                         SEQUENCE LISTING

<110>  CureVac AG
 
<120>  mRNA Encoding Therapeutic Proteins

<130>  CU01P222WO1

<160>  78370 

<170>  PatentIn version 3.5

<210>  1
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37135__Homo_sapiens__NP_443070

<400>  1

Met Ser His His Asp Asp Gly Ala Thr Val Gly Leu Gly Ile Gln Met 
1               5                   10                  15      


Cys Glu Gly Trp Arg Val Glu Ala Ala Leu Ser Phe Leu Pro His Gln 
            20                  25                  30          


Arg Lys Trp Gly Glu Thr Ala Gly Ala Val Met Ala Gly Gly Val Met 
        35                  40                  45              


Asp Lys Glu Tyr Val Gly Phe Ala Ala Leu Pro Asn Gln Leu His Arg 
    50                  55                  60                  


Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu 
65                  70                  75                  80  


Ser Gly Leu Gly Lys Ser Thr Leu Ile Asn Ser Leu Phe Leu Thr Asn 
                85                  90                  95      


Leu Tyr Glu Asp Arg Gln Val Pro Glu Ala Ser Ala Arg Leu Thr Gln 
            100                 105                 110         


Thr Leu Ala Ile Glu Arg Arg Gly Val Glu Ile Glu Glu Gly Gly Val 
        115                 120                 125             


Lys Val Lys Leu Thr Leu Val Asp Thr Pro Gly Phe Gly Asp Ser Val 
    130                 135                 140                 


Asp Cys Ser Asp Cys Trp Leu Pro Val Val Lys Phe Ile Glu Glu Gln 
145                 150                 155                 160 


Phe Glu Gln Tyr Leu Arg Asp Glu Ser Gly Leu Asn Arg Lys Asn Ile 
                165                 170                 175     


Gln Asp Ser Arg Val His Cys Cys Leu Tyr Phe Ile Ser Pro Phe Gly 
            180                 185                 190         


Arg Gly Leu Arg Pro Leu Asp Val Ala Phe Leu Arg Ala Val His Glu 
        195                 200                 205             


Lys Val Asn Ile Ile Pro Val Ile Gly Lys Ala Asp Ala Leu Met Pro 
    210                 215                 220                 


Gln Glu Thr Gln Ala Leu Lys Gln Lys Ile Arg Asp Gln Leu Lys Glu 
225                 230                 235                 240 


Glu Glu Ile His Ile Tyr Gln Phe Pro Glu Cys Asp Ser Asp Glu Asp 
                245                 250                 255     


Glu Asp Phe Lys Arg Gln Asp Ala Glu Met Lys Glu Ser Ile Pro Phe 
            260                 265                 270         


Ala Val Val Gly Ser Cys Glu Val Val Arg Asp Gly Gly Asn Arg Pro 
        275                 280                 285             


Val Arg Gly Arg Arg Tyr Ser Trp Gly Thr Val Glu Val Glu Asn Pro 
    290                 295                 300                 


His His Cys Asp Phe Leu Asn Leu Arg Arg Met Leu Val Gln Thr His 
305                 310                 315                 320 


Leu Gln Asp Leu Lys Glu Val Thr His Asp Leu Leu Tyr Glu Gly Tyr 
                325                 330                 335     


Arg Ala Arg Cys Leu Gln Ser Leu Ala Arg Pro Gly Ala Arg Asp Arg 
            340                 345                 350         


Ala Ser Arg Ser Lys Leu Ser Arg Gln Ser Ala Thr Glu Ile Pro Leu 
        355                 360                 365             


Pro Met Leu Pro Leu Ala Asp Thr Glu Lys Leu Ile Arg Glu Lys Asp 
    370                 375                 380                 


Glu Glu Leu Arg Arg Met Gln Glu Met Leu Glu Lys Met Gln Ala Gln 
385                 390                 395                 400 


Met Gln Gln Ser Gln Ala Gln Gly Glu Gln Ser Asp Ala Leu 
                405                 410                 


<210>  2
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37500__Homo_sapiens__NP_001008492

<400>  2

Met Ser Lys Gln Gln Pro Thr Gln Phe Ile Asn Pro Glu Thr Pro Gly 
1               5                   10                  15      


Tyr Val Gly Phe Ala Asn Leu Pro Asn Gln Val His Arg Lys Ser Val 
            20                  25                  30          


Lys Lys Gly Phe Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu 
        35                  40                  45              


Gly Lys Ser Thr Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Pro 
    50                  55                  60                  


Glu Arg Val Ile Pro Gly Ala Ala Glu Lys Ile Glu Arg Thr Val Gln 
65                  70                  75                  80  


Ile Glu Ala Ser Thr Val Glu Ile Glu Glu Arg Gly Val Lys Leu Arg 
                85                  90                  95      


Leu Thr Val Val Asp Thr Pro Gly Tyr Gly Asp Ala Ile Asn Cys Arg 
            100                 105                 110         


Asp Cys Phe Lys Thr Ile Ile Ser Tyr Ile Asp Glu Gln Phe Glu Arg 
        115                 120                 125             


Tyr Leu His Asp Glu Ser Gly Leu Asn Arg Arg His Ile Ile Asp Asn 
    130                 135                 140                 


Arg Val His Cys Cys Phe Tyr Phe Ile Ser Pro Phe Gly His Gly Leu 
145                 150                 155                 160 


Lys Pro Leu Asp Val Ala Phe Met Lys Ala Ile His Asn Lys Val Asn 
                165                 170                 175     


Ile Val Pro Val Ile Ala Lys Ala Asp Thr Leu Thr Leu Lys Glu Arg 
            180                 185                 190         


Glu Arg Leu Lys Lys Arg Ile Leu Asp Glu Ile Glu Glu His Asn Ile 
        195                 200                 205             


Lys Ile Tyr His Leu Pro Asp Ala Glu Ser Asp Glu Asp Glu Asp Phe 
    210                 215                 220                 


Lys Glu Gln Thr Arg Leu Leu Lys Ala Ser Ile Pro Phe Ser Val Val 
225                 230                 235                 240 


Gly Ser Asn Gln Leu Ile Glu Ala Lys Gly Lys Lys Val Arg Gly Arg 
                245                 250                 255     


Leu Tyr Pro Trp Gly Val Val Glu Val Glu Asn Pro Glu His Asn Asp 
            260                 265                 270         


Phe Leu Lys Leu Arg Thr Met Leu Ile Thr His Met Gln Asp Leu Gln 
        275                 280                 285             


Glu Val Thr Gln Asp Leu His Tyr Glu Asn Phe Arg Ser Glu Arg Leu 
    290                 295                 300                 


Lys Arg Gly Gly Arg Lys Val Glu Asn Glu Asp Met Asn Lys Asp Gln 
305                 310                 315                 320 


Ile Leu Leu Glu Lys Glu Ala Glu Leu Arg Arg Met Gln Glu Met Ile 
                325                 330                 335     


Ala Arg Met Gln Ala Gln Met Gln Met Gln Met Gln Gly Gly Asp Gly 
            340                 345                 350         


Asp Gly Gly Ala Leu Gly His His Val 
        355                 360     


<210>  3
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37865__Homo_sapiens__NP_061979

<400>  3

Met Ser Lys Gly Leu Pro Glu Thr Arg Thr Asp Ala Ala Met Ser Glu 
1               5                   10                  15      


Leu Val Pro Glu Pro Arg Pro Lys Pro Ala Val Pro Met Lys Pro Met 
            20                  25                  30          


Ser Ile Asn Ser Asn Leu Leu Gly Tyr Ile Gly Ile Asp Thr Ile Ile 
        35                  40                  45              


Glu Gln Met Arg Lys Lys Thr Met Lys Thr Gly Phe Asp Phe Asn Ile 
    50                  55                  60                  


Met Val Val Gly Gln Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Thr 
65                  70                  75                  80  


Leu Phe Lys Ser Gln Val Ser Arg Lys Ala Ser Ser Trp Asn Arg Glu 
                85                  90                  95      


Glu Lys Ile Pro Lys Thr Val Glu Ile Lys Ala Ile Gly His Val Ile 
            100                 105                 110         


Glu Glu Gly Gly Val Lys Met Lys Leu Thr Val Ile Asp Thr Pro Gly 
        115                 120                 125             


Phe Gly Asp Gln Ile Asn Asn Glu Asn Cys Trp Glu Pro Ile Glu Lys 
    130                 135                 140                 


Tyr Ile Asn Glu Gln Tyr Glu Lys Phe Leu Lys Glu Glu Val Asn Ile 
145                 150                 155                 160 


Ala Arg Lys Lys Arg Ile Pro Asp Thr Arg Val His Cys Cys Leu Tyr 
                165                 170                 175     


Phe Ile Ser Pro Thr Gly His Ser Leu Arg Pro Leu Asp Leu Glu Phe 
            180                 185                 190         


Met Lys His Leu Ser Lys Val Val Asn Ile Ile Pro Val Ile Ala Lys 
        195                 200                 205             


Ala Asp Thr Met Thr Leu Glu Glu Lys Ser Glu Phe Lys Gln Arg Val 
    210                 215                 220                 


Arg Lys Glu Leu Glu Val Asn Gly Ile Glu Phe Tyr Pro Gln Lys Glu 
225                 230                 235                 240 


Phe Asp Glu Asp Leu Glu Asp Lys Thr Glu Asn Asp Lys Ile Arg Gln 
                245                 250                 255     


Glu Ser Met Pro Phe Ala Val Val Gly Ser Asp Lys Glu Tyr Gln Val 
            260                 265                 270         


Asn Gly Lys Arg Val Leu Gly Arg Lys Thr Pro Trp Gly Ile Ile Glu 
        275                 280                 285             


Val Glu Asn Leu Asn His Cys Glu Phe Ala Leu Leu Arg Asp Phe Val 
    290                 295                 300                 


Ile Arg Thr His Leu Gln Asp Leu Lys Glu Val Thr His Asn Ile His 
305                 310                 315                 320 


Tyr Glu Thr Tyr Arg Ala Lys Arg Leu Asn Asp Asn Gly Gly Leu Pro 
                325                 330                 335     


Pro Val Ser Val Asp Thr Glu Glu Ser His Asp Ser Asn Pro 
            340                 345                 350 


<210>  4
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38231__Homo_sapiens__NP_001185642

<400>  4

Met Pro Gly Phe Tyr Ser Val Met Thr Asp Glu Glu Ile Lys Arg Phe 
1               5                   10                  15      


Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser Lys Phe Val Lys Asp 
            20                  25                  30          


Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu Ala Lys Thr Trp Ala 
        35                  40                  45              


Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln Ala Pro Asp Leu Tyr 
    50                  55                  60                  


Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg Pro Gln Ser Ser Asp 
65                  70                  75                  80  


Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu Ser Pro Ser Ala Arg 
                85                  90                  95      


Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr Asp Ser Ser Glu Asp 
            100                 105                 110         


Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg 
        115                 120                 125             


Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu 
    130                 135                 140                 


Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Ser Leu Phe Leu Thr Asp 
145                 150                 155                 160 


Leu Tyr Arg Asp Arg Lys Leu Leu Gly Ala Glu Glu Arg Ile Met Gln 
                165                 170                 175     


Thr Val Glu Ile Thr Lys His Ala Val Asp Ile Glu Glu Lys Gly Val 
            180                 185                 190         


Arg Leu Arg Leu Thr Ile Val Asp Thr Pro Gly Phe Gly Asp Ala Val 
        195                 200                 205             


Asn Asn Thr Glu Cys Trp Lys Pro Val Ala Glu Tyr Ile Asp Gln Gln 
    210                 215                 220                 


Phe Glu Gln Tyr Phe Arg Asp Glu Ser Gly Leu Asn Arg Lys Asn Ile 
225                 230                 235                 240 


Gln Asp Asn Arg Val His Cys Cys Leu Tyr Phe Ile Ser Pro Phe Gly 
                245                 250                 255     


His Gly Leu Arg Pro Leu Asp Val Glu Phe Met Lys Ala Leu His Gln 
            260                 265                 270         


Arg Val Asn Ile Val Pro Ile Leu Ala Lys Ala Asp Thr Leu Thr Pro 
        275                 280                 285             


Pro Glu Val Asp His Lys Lys Arg Lys Ile Arg Glu Glu Ile Glu His 
    290                 295                 300                 


Phe Gly Ile Lys Ile Tyr Gln Phe Pro Asp Cys Asp Ser Asp Glu Asp 
305                 310                 315                 320 


Glu Asp Phe Lys Leu Gln Asp Gln Ala Leu Lys Glu Ser Ile Pro Phe 
                325                 330                 335     


Ala Val Ile Gly Ser Asn Thr Val Val Glu Ala Arg Gly Arg Arg Val 
            340                 345                 350         


Arg Gly Arg Leu Tyr Pro Trp Gly Ile Val Glu Val Glu Asn Pro Gly 
        355                 360                 365             


His Cys Asp Phe Val Lys Leu Arg Thr Met Leu Val Arg Thr His Met 
    370                 375                 380                 


Gln Asp Leu Lys Asp Val Thr Arg Glu Thr His Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Ala Gln Cys Ile Gln Ser Met Thr Arg Leu Val Val Lys Glu Arg Asn 
                405                 410                 415     


Arg Asn Lys Leu Thr Arg Glu Ser Gly Thr Asp Phe Pro Ile Pro Ala 
            420                 425                 430         


Val Pro Pro Gly Thr Asp Pro Glu Thr Glu Lys Leu Ile Arg Glu Lys 
        435                 440                 445             


Asp Glu Glu Leu Arg Arg Met Gln Glu Met Leu His Lys Ile Gln Lys 
    450                 455                 460                 


Gln Met Lys Glu Asn Tyr 
465                 470 


<210>  5
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38596__Homo_sapiens__NP_001009939

<400>  5

Met Asp Ser Leu Ala Ala Pro Gln Asp Arg Leu Val Glu Gln Leu Leu 
1               5                   10                  15      


Ser Pro Arg Thr Gln Ala Gln Arg Arg Leu Lys Asp Ile Asp Lys Gln 
            20                  25                  30          


Tyr Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val 
        35                  40                  45              


Lys Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu Ser Gly Leu 
    50                  55                  60                  


Gly Lys Ser Thr Leu Val His Ser Leu Phe Leu Thr Asp Leu Tyr Lys 
65                  70                  75                  80  


Asp Arg Lys Leu Leu Ser Ala Glu Glu Arg Ile Ser Gln Thr Val Glu 
                85                  90                  95      


Ile Leu Lys His Thr Val Asp Ile Glu Glu Lys Gly Val Lys Leu Lys 
            100                 105                 110         


Leu Thr Ile Val Asp Thr Pro Gly Phe Gly Asp Ala Val Asn Asn Thr 
        115                 120                 125             


Glu Cys Trp Lys Pro Ile Thr Asp Tyr Val Asp Gln Gln Phe Glu Gln 
    130                 135                 140                 


Tyr Phe Arg Asp Glu Ser Gly Leu Asn Arg Lys Asn Ile Gln Asp Asn 
145                 150                 155                 160 


Arg Val His Cys Cys Leu Tyr Phe Ile Ser Pro Phe Gly His Gly Leu 
                165                 170                 175     


Arg Pro Val Asp Val Gly Phe Met Lys Ala Leu His Glu Lys Val Asn 
            180                 185                 190         


Ile Val Pro Leu Ile Ala Lys Ala Asp Cys Leu Val Pro Ser Glu Ile 
        195                 200                 205             


Arg Lys Leu Lys Glu Arg Ile Arg Glu Glu Ile Asp Lys Phe Gly Ile 
    210                 215                 220                 


His Val Tyr Gln Phe Pro Glu Cys Asp Ser Asp Glu Asp Glu Asp Phe 
225                 230                 235                 240 


Lys Gln Gln Asp Arg Glu Leu Lys Glu Ser Ala Pro Phe Ala Val Ile 
                245                 250                 255     


Gly Ser Asn Thr Val Val Glu Ala Lys Gly Gln Arg Val Arg Gly Arg 
            260                 265                 270         


Leu Tyr Pro Trp Gly Ile Val Glu Gly Ala Leu Arg Leu Arg Glu Ala 
        275                 280                 285             


Ala Gln His Ala His Pro His Ala Tyr Ala Arg Pro Gln Gly Arg Asp 
    290                 295                 300                 


Val Arg Arg Ala Leu Arg Glu Leu Pro Arg Ala Leu His Pro Ala Asp 
305                 310                 315                 320 


Asp Gln Gln Thr Asp Pro Gly Gln Pro His Gly Glu Pro His Pro Asp 
                325                 330                 335     


Pro Ala Ala Ala His Pro Gly Arg Arg Asp 
            340                 345     


<210>  6
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38961__Homo_sapiens__NP_055944

<400>  6

Met Ala Ala Thr Asp Ile Ala Arg Gln Val Gly Glu Gly Cys Arg Thr 
1               5                   10                  15      


Val Pro Leu Ala Gly His Val Gly Phe Asp Ser Leu Pro Asp Gln Leu 
            20                  25                  30          


Val Asn Lys Ser Val Ser Gln Gly Phe Cys Phe Asn Ile Leu Cys Val 
        35                  40                  45              


Gly Glu Thr Gly Leu Gly Lys Ser Thr Leu Met Asp Thr Leu Phe Asn 
    50                  55                  60                  


Thr Lys Phe Glu Gly Glu Pro Ala Thr His Thr Gln Pro Gly Val Gln 
65                  70                  75                  80  


Leu Gln Ser Asn Thr Tyr Asp Leu Gln Glu Ser Asn Val Arg Leu Lys 
                85                  90                  95      


Leu Thr Ile Val Ser Thr Val Gly Phe Gly Asp Gln Ile Asn Lys Glu 
            100                 105                 110         


Asp Ser Tyr Lys Pro Ile Val Glu Phe Ile Asp Ala Gln Phe Glu Ala 
        115                 120                 125             


Tyr Leu Gln Glu Glu Leu Lys Ile Arg Arg Val Leu His Thr Tyr His 
    130                 135                 140                 


Asp Ser Arg Ile His Val Cys Leu Tyr Phe Ile Ala Pro Thr Gly His 
145                 150                 155                 160 


Ser Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp Ser Lys 
                165                 170                 175     


Val Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Ala Ile Ser Lys Ser 
            180                 185                 190         


Glu Leu Thr Lys Phe Lys Ile Lys Ile Thr Ser Glu Leu Val Ser Asn 
        195                 200                 205             


Gly Val Gln Ile Tyr Gln Phe Pro Thr Asp Asp Glu Ser Val Ala Glu 
    210                 215                 220                 


Ile Asn Gly Thr Met Asn Ala His Leu Pro Phe Ala Val Ile Gly Ser 
225                 230                 235                 240 


Thr Glu Glu Leu Lys Ile Gly Asn Lys Met Met Arg Ala Arg Gln Tyr 
                245                 250                 255     


Pro Trp Gly Thr Val Gln Val Glu Asn Glu Ala His Cys Asp Phe Val 
            260                 265                 270         


Lys Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu Arg Glu 
        275                 280                 285             


Gln Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys Leu Glu 
    290                 295                 300                 


Glu Met Gly Phe Lys Asp Thr Asp Pro Asp Ser Lys Pro Phe Ser Leu 
305                 310                 315                 320 


Gln Glu Thr Tyr Glu Ala Lys Arg Asn Glu Phe Leu Gly Glu Leu Gln 
                325                 330                 335     


Lys Lys Glu Glu Glu Met Arg Gln Met Phe Val Gln Arg Val Lys Glu 
            340                 345                 350         


Lys Glu Ala Glu Leu Lys Glu Ala Glu Lys Glu Leu His Glu Lys Phe 
        355                 360                 365             


Asp Arg Leu Lys Lys Leu His Gln Asp Glu Lys Lys Lys Leu Glu Asp 
    370                 375                 380                 


Lys Lys Lys Ser Leu Asp Asp Glu Val Asn Ala Phe Lys Gln Arg Lys 
385                 390                 395                 400 


Thr Ala Ala Glu Leu Leu Gln Ser Gln Gly Ser Gln Ala Gly Gly Ser 
                405                 410                 415     


Gln Thr Leu Lys Arg Asp Lys Glu Lys Lys Asn Asn Pro Trp Leu Cys 
            420                 425                 430         


Thr Glu 
        


<210>  7
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39326__Homo_sapiens__NP_001011553

<400>  7

Met Ser Val Ser Ala Arg Ser Ala Ala Ala Glu Glu Arg Ser Val Asn 
1               5                   10                  15      


Ser Ser Thr Met Ala Gln Gln Lys Asn Leu Glu Gly Tyr Val Gly Phe 
            20                  25                  30          


Ala Asn Leu Pro Asn Gln Val Tyr Arg Lys Ser Val Lys Arg Gly Phe 
        35                  40                  45              


Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu Gly Lys Ser Thr 
    50                  55                  60                  


Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Ser Pro Glu Tyr Pro 
65                  70                  75                  80  


Gly Pro Ser His Arg Ile Lys Lys Thr Val Gln Val Glu Gln Ser Lys 
                85                  90                  95      


Val Leu Ile Lys Glu Gly Gly Val Gln Leu Leu Leu Thr Ile Val Asp 
            100                 105                 110         


Thr Pro Gly Phe Gly Asp Ala Val Asp Asn Ser Asn Cys Trp Gln Pro 
        115                 120                 125             


Val Ile Asp Tyr Ile Asp Ser Lys Phe Glu Asp Tyr Leu Asn Ala Glu 
    130                 135                 140                 


Ser Arg Val Asn Arg Arg Gln Met Pro Asp Asn Arg Val Gln Cys Cys 
145                 150                 155                 160 


Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Leu Lys Pro Leu Asp Ile 
                165                 170                 175     


Glu Phe Met Lys Arg Leu His Glu Lys Val Asn Ile Ile Pro Leu Ile 
            180                 185                 190         


Ala Lys Ala Asp Thr Leu Thr Pro Glu Glu Cys Gln Gln Phe Lys Lys 
        195                 200                 205             


Gln Ile Met Lys Glu Ile Gln Glu His Lys Ile Lys Ile Tyr Glu Phe 
    210                 215                 220                 


Pro Glu Thr Asp Asp Glu Glu Glu Asn Lys Leu Val Lys Lys Ile Lys 
225                 230                 235                 240 


Asp Arg Leu Pro Leu Ala Val Val Gly Ser Asn Thr Ile Ile Glu Val 
                245                 250                 255     


Asn Gly Lys Arg Val Arg Gly Arg Gln Tyr Pro Trp Gly Val Ala Glu 
            260                 265                 270         


Val Glu Asn Gly Glu His Cys Asp Phe Thr Ile Leu Arg Asn Met Leu 
        275                 280                 285             


Ile Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val His 
    290                 295                 300                 


Tyr Glu Asn Tyr Arg Ser Arg Lys Leu Ala Ala Val Thr Tyr Asn Gly 
305                 310                 315                 320 


Val Asp Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys Ser Pro Leu Ala 
                325                 330                 335     


Gln Met Glu Glu Glu Arg Arg Glu His Val Ala Lys Met Lys Lys Met 
            340                 345                 350         


Glu Met Glu Met Glu Gln Val Phe Glu Met Lys Val Lys Glu Lys Val 
        355                 360                 365             


Gln Lys Leu Lys Asp Ser Glu Ala Glu Leu Gln Arg Arg His Glu Gln 
    370                 375                 380                 


Met Lys Lys Asn Leu Glu Ala Gln His Lys Glu Leu Glu Glu Lys Arg 
385                 390                 395                 400 


Arg Gln Phe Glu Asp Glu Lys Ala Asn Trp Glu Ala Gln Gln Arg Ile 
                405                 410                 415     


Leu Glu Gln Gln Asn Ser Ser Arg Thr Leu Glu Lys Asn Lys Lys Lys 
            420                 425                 430         


Gly Lys Ile Phe 
        435     


<210>  8
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40057__Homo_sapiens__NP_001106963

<400>  8

Met Lys Lys Ser Tyr Ser Gly Gly Thr Arg Thr Ser Ser Gly Arg Leu 
1               5                   10                  15      


Arg Arg Leu Gly Asp Ser Ser Gly Pro Ala Leu Lys Arg Ser Phe Glu 
            20                  25                  30          


Val Glu Glu Val Glu Thr Pro Asn Ser Thr Pro Pro Arg Arg Val Gln 
        35                  40                  45              


Thr Pro Leu Leu Arg Ala Thr Val Ala Ser Ser Thr Gln Lys Phe Gln 
    50                  55                  60                  


Asp Leu Gly Val Lys Asn Ser Glu Pro Ser Ala Arg His Val Asp Ser 
65                  70                  75                  80  


Leu Ser Gln Arg Ser Pro Lys Ala Ser Leu Arg Arg Val Glu Leu Ser 
                85                  90                  95      


Gly Pro Lys Ala Ala Glu Pro Val Ser Arg Arg Thr Glu Leu Ser Ile 
            100                 105                 110         


Asp Ile Ser Ser Lys Gln Val Glu Asn Ala Gly Ala Ile Gly Pro Ser 
        115                 120                 125             


Arg Phe Gly Leu Lys Arg Ala Glu Val Leu Gly His Lys Thr Pro Glu 
    130                 135                 140                 


Pro Ala Pro Arg Arg Thr Glu Ile Thr Ile Val Lys Pro Gln Glu Ser 
145                 150                 155                 160 


Ala His Arg Arg Met Glu Pro Pro Ala Ser Lys Val Pro Glu Val Pro 
                165                 170                 175     


Thr Ala Pro Ala Thr Asp Ala Ala Pro Lys Arg Val Glu Ile Gln Met 
            180                 185                 190         


Pro Lys Pro Ala Glu Ala Pro Thr Ala Pro Ser Pro Ala Gln Thr Leu 
        195                 200                 205             


Glu Asn Ser Glu Pro Ala Pro Val Ser Gln Leu Gln Ser Arg Leu Glu 
    210                 215                 220                 


Pro Lys Pro Gln Pro Pro Val Ala Glu Ala Thr Pro Arg Ser Gln Glu 
225                 230                 235                 240 


Ala Thr Glu Ala Ala Pro Ser Cys Val Gly Asp Met Ala Asp Thr Pro 
                245                 250                 255     


Arg Asp Ala Gly Leu Lys Gln Ala Pro Ala Ser Arg Asn Glu Lys Ala 
            260                 265                 270         


Pro Val Asp Phe Gly Tyr Val Gly Ile Asp Ser Ile Leu Glu Gln Met 
        275                 280                 285             


Arg Arg Lys Ala Met Lys Gln Gly Phe Glu Phe Asn Ile Met Val Val 
    290                 295                 300                 


Gly Gln Ser Gly Leu Gly Lys Ser Thr Leu Ile Asn Thr Leu Phe Lys 
305                 310                 315                 320 


Ser Lys Ile Ser Arg Lys Ser Val Gln Pro Thr Ser Glu Glu Arg Ile 
                325                 330                 335     


Pro Lys Thr Ile Glu Ile Lys Ser Ile Thr His Asp Ile Glu Glu Lys 
            340                 345                 350         


Gly Val Arg Met Lys Leu Thr Val Ile Asp Thr Pro Gly Phe Gly Asp 
        355                 360                 365             


His Ile Asn Asn Glu Asn Cys Trp Gln Pro Ile Met Lys Phe Ile Asn 
    370                 375                 380                 


Asp Gln Tyr Glu Lys Tyr Leu Gln Glu Glu Val Asn Ile Asn Arg Lys 
385                 390                 395                 400 


Lys Arg Ile Pro Asp Thr Arg Val His Cys Cys Leu Tyr Phe Ile Pro 
                405                 410                 415     


Ala Thr Gly His Ser Leu Arg Pro Leu Asp Ile Glu Phe Met Lys Arg 
            420                 425                 430         


Leu Ser Lys Val Val Asn Ile Val Pro Val Ile Ala Lys Ala Asp Thr 
        435                 440                 445             


Leu Thr Leu Glu Glu Arg Val His Phe Lys Gln Arg Ile Thr Ala Asp 
    450                 455                 460                 


Leu Leu Ser Asn Gly Ile Asp Val Tyr Pro Gln Lys Glu Phe Asp Glu 
465                 470                 475                 480 


Asp Ser Glu Asp Arg Leu Val Asn Glu Lys Phe Arg Glu Met Ile Pro 
                485                 490                 495     


Phe Ala Val Val Gly Ser Asp His Glu Tyr Gln Val Asn Gly Lys Arg 
            500                 505                 510         


Ile Leu Gly Arg Lys Thr Lys Trp Gly Thr Ile Glu Val Glu Asn Thr 
        515                 520                 525             


Thr His Cys Glu Phe Ala Tyr Leu Arg Asp Leu Leu Ile Arg Thr His 
    530                 535                 540                 


Met Gln Asn Ile Lys Asp Ile Thr Ser Ser Ile His Phe Glu Ala Tyr 
545                 550                 555                 560 


Arg Val Lys Arg Leu Asn Glu Gly Ser Ser Ala Met Ala Asn Gly Met 
                565                 570                 575     


Glu Glu Lys Glu Pro Glu Ala Pro Glu Met 
            580                 585     


<210>  9
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40422__Homo_sapiens__NP_653311

<400>  9

Met Ala Ser Ser Glu Val Ala Arg His Leu Leu Phe Gln Ser His Met 
1               5                   10                  15      


Ala Thr Lys Thr Thr Cys Met Ser Ser Gln Gly Ser Asp Asp Glu Gln 
            20                  25                  30          


Ile Lys Arg Glu Asn Ile Arg Ser Leu Thr Met Ser Gly His Val Gly 
        35                  40                  45              


Phe Glu Ser Leu Pro Asp Gln Leu Val Asn Arg Ser Ile Gln Gln Gly 
    50                  55                  60                  


Phe Cys Phe Asn Ile Leu Cys Val Gly Glu Thr Gly Ile Gly Lys Ser 
65                  70                  75                  80  


Thr Leu Ile Asp Thr Leu Phe Asn Thr Asn Phe Glu Asp Tyr Glu Ser 
                85                  90                  95      


Ser His Phe Cys Pro Asn Val Lys Leu Lys Ala Gln Thr Tyr Glu Leu 
            100                 105                 110         


Gln Glu Ser Asn Val Gln Leu Lys Leu Thr Ile Val Asn Thr Val Gly 
        115                 120                 125             


Phe Gly Asp Gln Ile Asn Lys Glu Glu Ser Tyr Gln Pro Ile Val Asp 
    130                 135                 140                 


Tyr Ile Asp Ala Gln Phe Glu Ala Tyr Leu Gln Glu Glu Leu Lys Ile 
145                 150                 155                 160 


Lys Arg Ser Leu Phe Thr Tyr His Asp Ser Arg Ile His Val Cys Leu 
                165                 170                 175     


Tyr Phe Ile Ser Pro Thr Gly His Ser Leu Lys Thr Leu Asp Leu Leu 
            180                 185                 190         


Thr Met Lys Asn Leu Asp Ser Lys Val Asn Ile Ile Pro Val Ile Ala 
        195                 200                 205             


Lys Ala Asp Thr Val Ser Lys Thr Glu Leu Gln Lys Phe Lys Ile Lys 
    210                 215                 220                 


Leu Met Ser Glu Leu Val Ser Asn Gly Val Gln Ile Tyr Gln Phe Pro 
225                 230                 235                 240 


Thr Asp Asp Asp Thr Ile Ala Lys Val Asn Ala Ala Met Asn Gly Gln 
                245                 250                 255     


Leu Pro Phe Ala Val Val Gly Ser Met Asp Glu Val Lys Val Gly Asn 
            260                 265                 270         


Lys Met Val Lys Ala Arg Gln Tyr Pro Trp Gly Val Val Gln Val Glu 
        275                 280                 285             


Asn Glu Asn His Cys Asp Phe Val Lys Leu Arg Glu Met Leu Ile Cys 
    290                 295                 300                 


Thr Asn Met Glu Asp Leu Arg Glu Gln Thr His Thr Arg His Tyr Glu 
305                 310                 315                 320 


Leu Tyr Arg Arg Cys Lys Leu Glu Glu Met Gly Phe Thr Asp Val Gly 
                325                 330                 335     


Pro Glu Asn Lys Pro Val Ser Val Gln Glu Thr Tyr Glu Ala Lys Arg 
            340                 345                 350         


His Glu Phe His Gly Glu Arg Gln Arg Lys Glu Glu Glu Met Lys Gln 
        355                 360                 365             


Met Phe Val Gln Arg Val Lys Glu Lys Glu Ala Ile Leu Lys Glu Ala 
    370                 375                 380                 


Glu Arg Glu Leu Gln Ala Lys Phe Glu His Leu Lys Arg Leu His Gln 
385                 390                 395                 400 


Glu Glu Arg Met Lys Leu Glu Glu Lys Arg Arg Leu Leu Glu Glu Glu 
                405                 410                 415     


Ile Ile Ala Phe Ser Lys Lys Lys Ala Thr Ser Glu Ile Phe His Ser 
            420                 425                 430         


Gln Ser Phe Leu Ala Thr Gly Ser Asn Leu Arg Lys Asp Lys Asp Arg 
        435                 440                 445             


Lys Asn Ser Asn Phe Leu 
    450                 


<210>  10
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40787__Homo_sapiens__NP_060713

<400>  10

Met Ala Val Ala Val Gly Arg Pro Ser Asn Glu Glu Leu Arg Asn Leu 
1               5                   10                  15      


Ser Leu Ser Gly His Val Gly Phe Asp Ser Leu Pro Asp Gln Leu Val 
            20                  25                  30          


Asn Lys Ser Thr Ser Gln Gly Phe Cys Phe Asn Ile Leu Cys Val Gly 
        35                  40                  45              


Glu Thr Gly Ile Gly Lys Ser Thr Leu Met Asp Thr Leu Phe Asn Thr 
    50                  55                  60                  


Lys Phe Glu Ser Asp Pro Ala Thr His Asn Glu Pro Gly Val Arg Leu 
65                  70                  75                  80  


Lys Ala Arg Ser Tyr Glu Leu Gln Glu Ser Asn Val Arg Leu Lys Leu 
                85                  90                  95      


Thr Ile Val Asp Thr Val Gly Phe Gly Asp Gln Ile Asn Lys Asp Asp 
            100                 105                 110         


Ser Tyr Lys Pro Ile Val Glu Tyr Ile Asp Ala Gln Phe Glu Ala Tyr 
        115                 120                 125             


Leu Gln Glu Glu Leu Lys Ile Lys Arg Ser Leu Phe Asn Tyr His Asp 
    130                 135                 140                 


Thr Arg Ile His Ala Cys Leu Tyr Phe Ile Ala Pro Thr Gly His Ser 
145                 150                 155                 160 


Leu Lys Ser Leu Asp Leu Val Thr Met Lys Lys Leu Asp Ser Lys Val 
                165                 170                 175     


Asn Ile Ile Pro Ile Ile Ala Lys Ala Asp Thr Ile Ala Lys Asn Glu 
            180                 185                 190         


Leu His Lys Phe Lys Ser Lys Ile Met Ser Glu Leu Val Ser Asn Gly 
        195                 200                 205             


Val Gln Ile Tyr Gln Phe Pro Thr Asp Glu Glu Thr Val Ala Glu Ile 
    210                 215                 220                 


Asn Ala Thr Met Ser Val His Leu Pro Phe Ala Val Val Gly Ser Thr 
225                 230                 235                 240 


Glu Glu Val Lys Ile Gly Asn Lys Met Ala Lys Ala Arg Gln Tyr Pro 
                245                 250                 255     


Trp Gly Val Val Gln Val Glu Asn Glu Asn His Cys Asp Phe Val Lys 
            260                 265                 270         


Leu Arg Glu Met Leu Ile Arg Val Asn Met Glu Asp Leu Arg Glu Gln 
        275                 280                 285             


Thr His Thr Arg His Tyr Glu Leu Tyr Arg Arg Cys Lys Leu Glu Glu 
    290                 295                 300                 


Met Gly Phe Lys Asp Thr Asp Pro Asp Ser Lys Pro Phe Ser Leu Gln 
305                 310                 315                 320 


Glu Thr Tyr Glu Ala Lys Arg Asn Glu Phe Leu Gly Glu Leu Gln Lys 
                325                 330                 335     


Lys Glu Glu Glu Met Arg Gln Met Phe Val Met Arg Val Lys Glu Lys 
            340                 345                 350         


Glu Ala Glu Leu Lys Glu Ala Glu Lys Glu Leu His Glu Lys Phe Asp 
        355                 360                 365             


Leu Leu Lys Arg Thr His Gln Glu Glu Lys Lys Lys Val Glu Asp Lys 
    370                 375                 380                 


Lys Lys Glu Leu Glu Glu Glu Val Asn Asn Phe Gln Lys Lys Lys Ala 
385                 390                 395                 400 


Ala Ala Gln Leu Leu Gln Ser Gln Ala Gln Gln Ser Gly Ala Gln Gln 
                405                 410                 415     


Thr Lys Lys Asp Lys Asp Lys Lys Asn Ala Ser Phe Thr 
            420                 425                 


<210>  11
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41153__Homo_sapiens__NP_001147930

<400>  11

Met Asp Pro Leu Arg Arg Ser Pro Ser Pro Cys Leu Ser Ser Gln Pro 
1               5                   10                  15      


Ser Ser Pro Ser Thr Pro Pro Cys Glu Met Leu Gly Pro Val Gly Ile 
            20                  25                  30          


Glu Ala Val Leu Asp Gln Leu Lys Ile Lys Ala Met Lys Met Gly Phe 
        35                  40                  45              


Glu Phe Asn Ile Met Val Val Gly Gln Ser Gly Leu Gly Lys Ser Thr 
    50                  55                  60                  


Met Val Asn Thr Leu Phe Lys Ser Lys Val Trp Lys Ser Asn Pro Pro 
65                  70                  75                  80  


Gly Leu Gly Val Pro Thr Pro Gln Thr Leu Gln Leu His Ser Leu Thr 
                85                  90                  95      


His Val Ile Glu Glu Lys Gly Val Lys Leu Lys Leu Thr Val Thr Asp 
            100                 105                 110         


Thr Pro Gly Phe Gly Asp Gln Ile Asn Asn Asp Asn Cys Leu Arg Pro 
        115                 120                 125             


Leu Asp Ile Glu Phe Leu Gln Arg Leu Cys Arg Thr Val Asn Val Val 
    130                 135                 140                 


Pro Val Ile Ala Arg Ala Asp Ser Leu Thr Met Glu Glu Arg Glu Ala 
145                 150                 155                 160 


Phe Arg Arg Arg Ile Gln Gln Asn Leu Arg Thr His Cys Ile Asp Val 
                165                 170                 175     


Tyr Pro Gln Met Cys Phe Asp Glu Asp Ile Asn Asp Lys Ile Leu Asn 
            180                 185                 190         


Ser Lys Leu Arg Asp Arg Ile Pro Phe Ala Val Val Gly Ala Asp Gln 
        195                 200                 205             


Glu His Leu Val Asn Gly Arg Cys Val Leu Gly Arg Lys Thr Lys Trp 
    210                 215                 220                 


Gly Ile Ile Glu Val Glu Asn Met Ala His Cys Glu Phe Pro Leu Leu 
225                 230                 235                 240 


Arg Asp Leu Leu Ile Arg Ser His Leu Gln Asp Leu Lys Asp Ile Thr 
                245                 250                 255     


His Asn Ile His Tyr Glu Asn Tyr Arg Val Ile Arg Leu Asn Glu Ser 
            260                 265                 270         


His Leu Leu Pro Arg Gly Pro Gly Trp Val Asn Leu Ala Pro Ala Ser 
        275                 280                 285             


Pro Gly Gln Leu Thr Thr Pro Arg Thr Phe Lys Val Cys Arg Gly Ala 
    290                 295                 300                 


His Asp Asp Ser Asp Asp Glu Phe 
305                 310         


<210>  12
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41883__Homo_sapiens__NP_997249

<400>  12

Met Ala Glu Arg Thr Met Ala Met Pro Thr Gln Ile Pro Ala Asp Gly 
1               5                   10                  15      


Asp Thr Gln Lys Glu Asn Asn Ile Arg Cys Leu Thr Thr Ile Gly His 
            20                  25                  30          


Phe Gly Phe Glu Cys Leu Pro Asn Gln Leu Val Ser Arg Ser Ile Arg 
        35                  40                  45              


Gln Gly Phe Thr Phe Asn Ile Leu Cys Val Gly Glu Thr Gly Ile Gly 
    50                  55                  60                  


Lys Ser Thr Leu Ile Asp Thr Leu Phe Asn Thr Asn Leu Lys Asp Asn 
65                  70                  75                  80  


Lys Ser Ser His Phe Tyr Ser Asn Val Gly Leu Gln Ile Gln Thr Tyr 
                85                  90                  95      


Glu Leu Gln Glu Ser Asn Val Gln Leu Lys Leu Thr Val Val Glu Thr 
            100                 105                 110         


Val Gly Tyr Gly Asp Gln Ile Asp Lys Glu Ala Ser Tyr Gln Pro Ile 
        115                 120                 125             


Val Asp Tyr Ile Asp Ala Gln Phe Glu Ala Tyr Leu Gln Glu Glu Leu 
    130                 135                 140                 


Lys Ile Lys Arg Ser Leu Phe Glu Tyr His Asp Ser Arg Val His Val 
145                 150                 155                 160 


Cys Leu Tyr Phe Ile Ser Pro Thr Gly His Ser Leu Lys Ser Leu Asp 
                165                 170                 175     


Leu Leu Thr Met Lys Asn Leu Asp Ser Lys Val Asn Ile Ile Pro Leu 
            180                 185                 190         


Ile Ala Lys Ala Asp Thr Ile Ser Lys Asn Asp Leu Gln Thr Phe Lys 
        195                 200                 205             


Asn Lys Ile Met Ser Glu Leu Ile Ser Asn Gly Ile Gln Ile Tyr Gln 
    210                 215                 220                 


Leu Pro Thr Asp Glu Glu Thr Ala Ala Gln Ala Asn Ser Ser Val Ser 
225                 230                 235                 240 


Gly Leu Leu Pro Phe Ala Val Val Gly Ser Thr Asp Glu Val Lys Val 
                245                 250                 255     


Gly Lys Arg Met Val Arg Gly Arg His Tyr Pro Trp Gly Val Leu Gln 
            260                 265                 270         


Val Glu Asn Glu Asn His Cys Asp Phe Val Lys Leu Arg Asp Met Leu 
        275                 280                 285             


Leu Cys Thr Asn Met Glu Asn Leu Lys Glu Lys Thr His Thr Gln His 
    290                 295                 300                 


Tyr Glu Cys Tyr Arg Tyr Gln Lys Leu Gln Lys Met Gly Phe Thr Asp 
305                 310                 315                 320 


Val Gly Pro Asn Asn Gln Pro Val Ser Phe Gln Glu Ile Phe Glu Ala 
                325                 330                 335     


Lys Arg Gln Glu Phe Tyr Asp Gln Cys Gln Arg Glu Glu Glu Glu Leu 
            340                 345                 350         


Lys Gln Arg Phe Met Gln Arg Val Lys Glu Lys Glu Ala Thr Phe Lys 
        355                 360                 365             


Glu Ala Glu Lys Glu Leu Gln Asp Lys Phe Glu His Leu Lys Met Ile 
    370                 375                 380                 


Gln Gln Glu Glu Ile Arg Lys Leu Glu Glu Glu Lys Lys Gln Leu Glu 
385                 390                 395                 400 


Gly Glu Ile Ile Asp Phe Tyr Lys Met Lys Ala Ala Ser Glu Ala Leu 
                405                 410                 415     


Gln Thr Gln Leu Ser Thr Asp Thr Lys Lys Asp Lys His Arg Lys Lys 
            420                 425                 430         


<210>  13
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1BG__Homo_sapiens__NP_570602

<400>  13

Met Ser Met Leu Val Val Phe Leu Leu Leu Trp Gly Val Thr Trp Gly 
1               5                   10                  15      


Pro Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln Pro Ser Leu Trp 
            20                  25                  30          


Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Asn Val Thr Leu Thr 
        35                  40                  45              


Cys Gln Ala His Leu Glu Thr Pro Asp Phe Gln Leu Phe Lys Asn Gly 
    50                  55                  60                  


Val Ala Gln Glu Pro Val His Leu Asp Ser Pro Ala Ile Lys His Gln 
65                  70                  75                  80  


Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg Tyr Arg Cys Arg Ser Gly 
                85                  90                  95      


Leu Ser Thr Gly Trp Thr Gln Leu Ser Lys Leu Leu Glu Leu Thr Gly 
            100                 105                 110         


Pro Lys Ser Leu Pro Ala Pro Trp Leu Ser Met Ala Pro Val Ser Trp 
        115                 120                 125             


Ile Thr Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val Leu Arg 
    130                 135                 140                 


Gly Val Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe Leu Glu 
145                 150                 155                 160 


Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val His Gln 
                165                 170                 175     


Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly Glu Gly Ala Leu 
            180                 185                 190         


Ser Glu Pro Ser Ala Thr Val Thr Ile Glu Glu Leu Ala Ala Pro Pro 
        195                 200                 205             


Pro Pro Val Leu Met His His Gly Glu Ser Ser Gln Val Leu His Pro 
    210                 215                 220                 


Gly Asn Lys Val Thr Leu Thr Cys Val Ala Pro Leu Ser Gly Val Asp 
225                 230                 235                 240 


Phe Gln Leu Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser 
                245                 250                 255     


Thr Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly 
            260                 265                 270         


Asp Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn 
        275                 280                 285             


Gly Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser Asp Glu 
    290                 295                 300                 


Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu Ser Gly Arg Ala 
305                 310                 315                 320 


Leu Arg Leu Arg Cys Leu Ala Pro Leu Glu Gly Ala Arg Phe Ala Leu 
                325                 330                 335     


Val Arg Glu Asp Arg Gly Gly Arg Arg Val His Arg Phe Gln Ser Pro 
            340                 345                 350         


Ala Gly Thr Glu Ala Leu Phe Glu Leu His Asn Ile Ser Val Ala Asp 
        355                 360                 365             


Ser Ala Asn Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe Gly 
    370                 375                 380                 


Gly Ser Ala Pro Ser Glu Arg Leu Glu Leu His Val Asp Gly Pro Pro 
385                 390                 395                 400 


Pro Arg Pro Gln Leu Arg Ala Thr Trp Ser Gly Ala Val Leu Ala Gly 
                405                 410                 415     


Arg Asp Ala Val Leu Arg Cys Glu Gly Pro Ile Pro Asp Val Thr Phe 
            420                 425                 430         


Glu Leu Leu Arg Glu Gly Glu Thr Lys Ala Val Lys Thr Val Arg Thr 
        435                 440                 445             


Pro Gly Ala Ala Ala Asn Leu Glu Leu Ile Phe Val Gly Pro Gln His 
    450                 455                 460                 


Ala Gly Asn Tyr Arg Cys Arg Tyr Arg Ser Trp Val Pro His Thr Phe 
465                 470                 475                 480 


Glu Ser Glu Leu Ser Asp Pro Val Glu Leu Leu Val Ala Glu Ser 
                485                 490                 495 


<210>  14
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1CF__Homo_sapiens__NP_001185747

<400>  14

Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys 
1               5                   10                  15      


Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val 
            20                  25                  30          


Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp 
        35                  40                  45              


Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro 
    50                  55                  60                  


Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly 
65                  70                  75                  80  


Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg 
                85                  90                  95      


Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala 
            100                 105                 110         


Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly 
        115                 120                 125             


Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro 
    130                 135                 140                 


Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr 
145                 150                 155                 160 


Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr 
                165                 170                 175     


Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Arg Arg Lys Leu Leu Pro Gly Arg Ile Gln Leu Trp Gly 
        195                 200                 205             


His Gly Ile Ala Val Asp Trp Ala Glu Pro Glu Val Glu Val Asp Glu 
    210                 215                 220                 


Asp Thr Met Ser Ser Val Lys Ile Leu Tyr Val Arg Asn Leu Met Leu 
225                 230                 235                 240 


Ser Thr Ser Glu Glu Met Ile Glu Lys Glu Phe Asn Asn Ile Lys Pro 
                245                 250                 255     


Gly Ala Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His 
            260                 265                 270         


Phe Ser Asn Arg Glu Asp Ala Val Glu Ala Met Lys Ala Leu Asn Gly 
        275                 280                 285             


Lys Val Leu Asp Gly Ser Pro Ile Glu Val Thr Leu Ala Lys Pro Val 
    290                 295                 300                 


Asp Lys Asp Ser Tyr Val Arg Tyr Thr Arg Gly Thr Gly Gly Arg Gly 
305                 310                 315                 320 


Thr Met Leu Gln Gly Glu Tyr Thr Tyr Ser Leu Gly Gln Val Tyr Asp 
                325                 330                 335     


Pro Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe Tyr Ala Pro Gln Thr 
            340                 345                 350         


Tyr Ala Ala Ile Pro Ser Leu His Phe Pro Ala Thr Lys Gly His Leu 
        355                 360                 365             


Ser Asn Arg Ala Ile Ile Arg Ala Pro Ser Val Arg Gly Ala Ala Gly 
    370                 375                 380                 


Val Arg Gly Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu Gly 
385                 390                 395                 400 


Arg Gly Tyr Gln Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr Asp 
                405                 410                 415     


Ile Leu Pro Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu Lys 
            420                 425                 430         


Pro Gln Gly Ile Lys Leu Ala Pro Gln Ile Leu Glu Glu Ile Cys Gln 
        435                 440                 445             


Lys Asn Asn Trp Gly Gln Pro Val Tyr Gln Leu His Ser Ala Ile Gly 
    450                 455                 460                 


Gln Asp Gln Arg Gln Leu Phe Leu Tyr Lys Ile Thr Ile Pro Ala Leu 
465                 470                 475                 480 


Ala Ser Gln Asn Pro Ala Ile His Pro Phe Thr Pro Pro Lys Leu Ser 
                485                 490                 495     


Ala Phe Val Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu Gln 
            500                 505                 510         


Thr Leu Gly Ile Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr Ala 
        515                 520                 525             


Ala Ala Ala Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala Thr 
    530                 535                 540                 


Ala Pro Val Ser Ala Ala Gln Leu Lys Gln Ala Val Thr Leu Gly Gln 
545                 550                 555                 560 


Asp Leu Ala Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala Val 
                565                 570                 575     


Thr Ala Arg Gly Asp Gly Tyr Gly Thr Phe 
            580                 585     


<210>  15
<211>  1474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2M__Homo_sapiens__NP_000005

<400>  15

Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala 
    


<210>  16
<211>  1454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2ML1__Homo_sapiens__NP_653271

<400>  16

Met Trp Ala Gln Leu Leu Leu Gly Met Leu Ala Leu Ser Pro Ala Ile 
1               5                   10                  15      


Ala Glu Glu Leu Pro Asn Tyr Leu Val Thr Leu Pro Ala Arg Leu Asn 
            20                  25                  30          


Phe Pro Ser Val Gln Lys Val Cys Leu Asp Leu Ser Pro Gly Tyr Ser 
        35                  40                  45              


Asp Val Lys Phe Thr Val Thr Leu Glu Thr Lys Asp Lys Thr Gln Lys 
    50                  55                  60                  


Leu Leu Glu Tyr Ser Gly Leu Lys Lys Arg His Leu His Cys Ile Ser 
65                  70                  75                  80  


Phe Leu Val Pro Pro Pro Ala Gly Gly Thr Glu Glu Val Ala Thr Ile 
                85                  90                  95      


Arg Val Ser Gly Val Gly Asn Asn Ile Ser Phe Glu Glu Lys Lys Lys 
            100                 105                 110         


Val Leu Ile Gln Arg Gln Gly Asn Gly Thr Phe Val Gln Thr Asp Lys 
        115                 120                 125             


Pro Leu Tyr Thr Pro Gly Gln Gln Val Tyr Phe Arg Ile Val Thr Met 
    130                 135                 140                 


Asp Ser Asn Phe Val Pro Val Asn Asp Lys Tyr Ser Met Val Glu Leu 
145                 150                 155                 160 


Gln Asp Pro Asn Ser Asn Arg Ile Ala Gln Trp Leu Glu Val Val Pro 
                165                 170                 175     


Glu Gln Gly Ile Val Asp Leu Ser Phe Gln Leu Ala Pro Glu Ala Met 
            180                 185                 190         


Leu Gly Thr Tyr Thr Val Ala Val Ala Glu Gly Lys Thr Phe Gly Thr 
        195                 200                 205             


Phe Ser Val Glu Glu Tyr Val Leu Pro Lys Phe Lys Val Glu Val Val 
    210                 215                 220                 


Glu Pro Lys Glu Leu Ser Thr Val Gln Glu Ser Phe Leu Val Lys Ile 
225                 230                 235                 240 


Cys Cys Arg Tyr Thr Tyr Gly Lys Pro Met Leu Gly Ala Val Gln Val 
                245                 250                 255     


Ser Val Cys Gln Lys Ala Asn Thr Tyr Trp Tyr Arg Glu Val Glu Arg 
            260                 265                 270         


Glu Gln Leu Pro Asp Lys Cys Arg Asn Leu Ser Gly Gln Thr Asp Lys 
        275                 280                 285             


Thr Gly Cys Phe Ser Ala Pro Val Asp Met Ala Thr Phe Asp Leu Ile 
    290                 295                 300                 


Gly Tyr Ala Tyr Ser His Gln Ile Asn Ile Val Ala Thr Val Val Glu 
305                 310                 315                 320 


Glu Gly Thr Gly Val Glu Ala Asn Ala Thr Gln Asn Ile Tyr Ile Ser 
                325                 330                 335     


Pro Gln Met Gly Ser Met Thr Phe Glu Asp Thr Ser Asn Phe Tyr His 
            340                 345                 350         


Pro Asn Phe Pro Phe Ser Gly Lys Ile Arg Val Arg Gly His Asp Asp 
        355                 360                 365             


Ser Phe Leu Lys Asn His Leu Val Phe Leu Val Ile Tyr Gly Thr Asn 
    370                 375                 380                 


Gly Thr Phe Asn Gln Thr Leu Val Thr Asp Asn Asn Gly Leu Ala Pro 
385                 390                 395                 400 


Phe Thr Leu Glu Thr Ser Gly Trp Asn Gly Thr Asp Val Ser Leu Glu 
                405                 410                 415     


Gly Lys Phe Gln Met Glu Asp Leu Val Tyr Asn Pro Glu Gln Val Pro 
            420                 425                 430         


Arg Tyr Tyr Gln Asn Ala Tyr Leu His Leu Arg Pro Phe Tyr Ser Thr 
        435                 440                 445             


Thr Arg Ser Phe Leu Gly Ile His Arg Leu Asn Gly Pro Leu Lys Cys 
    450                 455                 460                 


Gly Gln Pro Gln Glu Val Leu Val Asp Tyr Tyr Ile Asp Pro Ala Asp 
465                 470                 475                 480 


Ala Ser Pro Asp Gln Glu Ile Ser Phe Ser Tyr Tyr Leu Ile Gly Lys 
                485                 490                 495     


Gly Ser Leu Val Met Glu Gly Gln Lys His Leu Asn Ser Lys Lys Lys 
            500                 505                 510         


Gly Leu Lys Ala Ser Phe Ser Leu Ser Leu Thr Phe Thr Ser Arg Leu 
        515                 520                 525             


Ala Pro Asp Pro Ser Leu Val Ile Tyr Ala Ile Phe Pro Ser Gly Gly 
    530                 535                 540                 


Val Val Ala Asp Lys Ile Gln Phe Ser Val Glu Met Cys Phe Asp Asn 
545                 550                 555                 560 


Gln Val Ser Leu Gly Phe Ser Pro Ser Gln Gln Leu Pro Gly Ala Glu 
                565                 570                 575     


Val Glu Leu Gln Leu Gln Ala Ala Pro Gly Ser Leu Cys Ala Leu Arg 
            580                 585                 590         


Ala Val Asp Glu Ser Val Leu Leu Leu Arg Pro Asp Arg Glu Leu Ser 
        595                 600                 605             


Asn Arg Ser Val Tyr Gly Met Phe Pro Phe Trp Tyr Gly His Tyr Pro 
    610                 615                 620                 


Tyr Gln Val Ala Glu Tyr Asp Gln Cys Pro Val Ser Gly Pro Trp Asp 
625                 630                 635                 640 


Phe Pro Gln Pro Leu Ile Asp Pro Met Pro Gln Gly His Ser Ser Gln 
                645                 650                 655     


Arg Ser Ile Ile Trp Arg Pro Ser Phe Ser Glu Gly Thr Asp Leu Phe 
            660                 665                 670         


Ser Phe Phe Arg Asp Val Gly Leu Lys Ile Leu Ser Asn Ala Lys Ile 
        675                 680                 685             


Lys Lys Pro Val Asp Cys Ser His Arg Ser Pro Glu Tyr Ser Thr Ala 
    690                 695                 700                 


Met Gly Ala Gly Gly Gly His Pro Glu Ala Phe Glu Ser Ser Thr Pro 
705                 710                 715                 720 


Leu His Gln Ala Glu Asp Ser Gln Val Arg Gln Tyr Phe Pro Glu Thr 
                725                 730                 735     


Trp Leu Trp Asp Leu Phe Pro Ile Gly Asn Ser Gly Lys Glu Ala Val 
            740                 745                 750         


His Val Thr Val Pro Asp Ala Ile Thr Glu Trp Lys Ala Met Ser Phe 
        755                 760                 765             


Cys Thr Ser Gln Ser Arg Gly Phe Gly Leu Ser Pro Thr Val Gly Leu 
    770                 775                 780                 


Thr Ala Phe Lys Pro Phe Phe Val Asp Leu Thr Leu Pro Tyr Ser Val 
785                 790                 795                 800 


Val Arg Gly Glu Ser Phe Arg Leu Thr Ala Thr Ile Phe Asn Tyr Leu 
                805                 810                 815     


Lys Asp Cys Ile Arg Val Gln Thr Asp Leu Ala Lys Ser His Glu Tyr 
            820                 825                 830         


Gln Leu Glu Ser Trp Ala Asp Ser Gln Thr Ser Ser Cys Leu Cys Ala 
        835                 840                 845             


Asp Glu Ala Lys Thr His His Trp Asn Ile Thr Ala Val Lys Leu Gly 
    850                 855                 860                 


His Ile Asn Phe Thr Ile Ser Thr Lys Ile Leu Asp Ser Asn Glu Pro 
865                 870                 875                 880 


Cys Gly Gly Gln Lys Gly Phe Val Pro Gln Lys Gly Arg Ser Asp Thr 
                885                 890                 895     


Leu Ile Lys Pro Val Leu Val Lys Pro Glu Gly Val Leu Val Glu Lys 
            900                 905                 910         


Thr His Ser Ser Leu Leu Cys Pro Lys Gly Lys Val Ala Ser Glu Ser 
        915                 920                 925             


Val Ser Leu Glu Leu Pro Val Asp Ile Val Pro Asp Ser Thr Lys Ala 
    930                 935                 940                 


Tyr Val Thr Val Leu Gly Asp Ile Met Gly Thr Ala Leu Gln Asn Leu 
945                 950                 955                 960 


Asp Gly Leu Val Gln Met Pro Ser Gly Cys Gly Glu Gln Asn Met Val 
                965                 970                 975     


Leu Phe Ala Pro Ile Ile Tyr Val Leu Gln Tyr Leu Glu Lys Ala Gly 
            980                 985                 990         


Leu Leu Thr Glu Glu Ile Arg Ser  Arg Ala Val Gly Phe  Leu Glu Ile 
        995                 1000                 1005             


Gly Tyr  Gln Lys Glu Leu Met  Tyr Lys His Ser Asn  Gly Ser Tyr 
    1010                 1015                 1020             


Ser Ala  Phe Gly Glu Arg Asp  Gly Asn Gly Asn Thr  Trp Leu Thr 
    1025                 1030                 1035             


Ala Phe  Val Thr Lys Cys Phe  Gly Gln Ala Gln Lys  Phe Ile Phe 
    1040                 1045                 1050             


Ile Asp  Pro Lys Asn Ile Gln  Asp Ala Leu Lys Trp  Met Ala Gly 
    1055                 1060                 1065             


Asn Gln  Leu Pro Ser Gly Cys  Tyr Ala Asn Val Gly  Asn Leu Leu 
    1070                 1075                 1080             


His Thr  Ala Met Lys Gly Gly  Val Asp Asp Glu Val  Ser Leu Thr 
    1085                 1090                 1095             


Ala Tyr  Val Thr Ala Ala Leu  Leu Glu Met Gly Lys  Asp Val Asp 
    1100                 1105                 1110             


Asp Pro  Met Val Ser Gln Gly  Leu Arg Cys Leu Lys  Asn Ser Ala 
    1115                 1120                 1125             


Thr Ser  Thr Thr Asn Leu Tyr  Thr Gln Ala Leu Leu  Ala Tyr Ile 
    1130                 1135                 1140             


Phe Ser  Leu Ala Gly Glu Met  Asp Ile Arg Asn Ile  Leu Leu Lys 
    1145                 1150                 1155             


Gln Leu  Asp Gln Gln Ala Ile  Ile Ser Gly Glu Ser  Ile Tyr Trp 
    1160                 1165                 1170             


Ser Gln  Lys Pro Thr Pro Ser  Ser Asn Ala Ser Pro  Trp Ser Glu 
    1175                 1180                 1185             


Pro Ala  Ala Val Asp Val Glu  Leu Thr Ala Tyr Ala  Leu Leu Ala 
    1190                 1195                 1200             


Gln Leu  Thr Lys Pro Ser Leu  Thr Gln Lys Glu Ile  Ala Lys Ala 
    1205                 1210                 1215             


Thr Ser  Ile Val Ala Trp Leu  Ala Lys Gln Arg Asn  Ala Tyr Gly 
    1220                 1225                 1230             


Gly Phe  Ser Ser Thr Gln Asp  Thr Val Val Ala Leu  Gln Ala Leu 
    1235                 1240                 1245             


Ala Lys  Tyr Ala Thr Thr Ala  Tyr Met Pro Ser Glu  Glu Ile Asn 
    1250                 1255                 1260             


Leu Val  Val Lys Ser Thr Glu  Asn Phe Gln Arg Thr  Phe Asn Ile 
    1265                 1270                 1275             


Gln Ser  Val Asn Arg Leu Val  Phe Gln Gln Asp Thr  Leu Pro Asn 
    1280                 1285                 1290             


Val Pro  Gly Met Tyr Thr Leu  Glu Ala Ser Gly Gln  Gly Cys Val 
    1295                 1300                 1305             


Tyr Val  Gln Thr Val Leu Arg  Tyr Asn Ile Leu Pro  Pro Thr Asn 
    1310                 1315                 1320             


Met Lys  Thr Phe Ser Leu Ser  Val Glu Ile Gly Lys  Ala Arg Cys 
    1325                 1330                 1335             


Glu Gln  Pro Thr Ser Pro Arg  Ser Leu Thr Leu Thr  Ile His Thr 
    1340                 1345                 1350             


Ser Tyr  Val Gly Ser Arg Ser  Ser Ser Asn Met Ala  Ile Val Glu 
    1355                 1360                 1365             


Val Lys  Met Leu Ser Gly Phe  Ser Pro Met Glu Gly  Thr Asn Gln 
    1370                 1375                 1380             


Leu Leu  Leu Gln Gln Pro Leu  Val Lys Lys Val Glu  Phe Gly Thr 
    1385                 1390                 1395             


Asp Thr  Leu Asn Ile Tyr Leu  Asp Glu Leu Ile Lys  Asn Thr Gln 
    1400                 1405                 1410             


Thr Tyr  Thr Phe Thr Ile Ser  Gln Ser Val Leu Val  Thr Asn Leu 
    1415                 1420                 1425             


Lys Pro  Ala Thr Ile Lys Val  Tyr Asp Tyr Tyr Leu  Pro Asp Glu 
    1430                 1435                 1440             


Gln Ala  Thr Ile Gln Tyr Ser  Asp Pro Cys Glu 
    1445                 1450                 


<210>  17
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A4GNT__Homo_sapiens__NP_057245

<400>  17

Met Arg Lys Glu Leu Gln Leu Ser Leu Ser Val Thr Leu Leu Leu Val 
1               5                   10                  15      


Cys Gly Phe Leu Tyr Gln Phe Thr Leu Lys Ser Ser Cys Leu Phe Cys 
            20                  25                  30          


Leu Pro Ser Phe Lys Ser His Gln Gly Leu Glu Ala Leu Leu Ser His 
        35                  40                  45              


Arg Arg Gly Ile Val Phe Leu Glu Thr Ser Glu Arg Met Glu Pro Pro 
    50                  55                  60                  


His Leu Val Ser Cys Ser Val Glu Ser Ala Ala Lys Ile Tyr Pro Glu 
65                  70                  75                  80  


Trp Pro Val Val Phe Phe Met Lys Gly Leu Thr Asp Ser Thr Pro Met 
                85                  90                  95      


Pro Ser Asn Ser Thr Tyr Pro Ala Phe Ser Phe Leu Ser Ala Ile Asp 
            100                 105                 110         


Asn Val Phe Leu Phe Pro Leu Asp Met Lys Arg Leu Leu Glu Asp Thr 
        115                 120                 125             


Pro Leu Phe Ser Trp Tyr Asn Gln Ile Asn Ala Ser Ala Glu Arg Asn 
    130                 135                 140                 


Trp Leu His Ile Ser Ser Asp Ala Ser Arg Leu Ala Ile Ile Trp Lys 
145                 150                 155                 160 


Tyr Gly Gly Ile Tyr Met Asp Thr Asp Val Ile Ser Ile Arg Pro Ile 
                165                 170                 175     


Pro Glu Glu Asn Phe Leu Ala Ala Gln Ala Ser Arg Tyr Ser Ser Asn 
            180                 185                 190         


Gly Ile Phe Gly Phe Leu Pro His His Pro Phe Leu Trp Glu Cys Met 
        195                 200                 205             


Glu Asn Phe Val Glu His Tyr Asn Ser Ala Ile Trp Gly Asn Gln Gly 
    210                 215                 220                 


Pro Glu Leu Met Thr Arg Met Leu Arg Val Trp Cys Lys Leu Glu Asp 
225                 230                 235                 240 


Phe Gln Glu Val Ser Asp Leu Arg Cys Leu Asn Ile Ser Phe Leu His 
                245                 250                 255     


Pro Gln Arg Phe Tyr Pro Ile Ser Tyr Arg Glu Trp Arg Arg Tyr Tyr 
            260                 265                 270         


Glu Val Trp Asp Thr Glu Pro Ser Phe Asn Val Ser Tyr Ala Leu His 
        275                 280                 285             


Leu Trp Asn His Met Asn Gln Glu Gly Arg Ala Val Ile Arg Gly Ser 
    290                 295                 300                 


Asn Thr Leu Val Glu Asn Leu Tyr Arg Lys His Cys Pro Arg Thr Tyr 
305                 310                 315                 320 


Arg Asp Leu Ile Lys Gly Pro Glu Gly Ser Val Thr Gly Glu Leu Gly 
                325                 330                 335     


Pro Gly Asn Lys 
            340 


<210>  18
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAAS__Homo_sapiens__NP_001166937

<400>  18

Met Cys Ser Leu Gly Leu Phe Pro Pro Pro Pro Pro Arg Gly Gln Val 
1               5                   10                  15      


Thr Leu Tyr Glu His Asn Asn Glu Leu Val Thr Gly Ser Ser Tyr Glu 
            20                  25                  30          


Ser Pro Pro Pro Asp Phe Arg Gly Gln Trp Ile Asn Leu Pro Val Leu 
        35                  40                  45              


Gln Leu Thr Lys Asp Pro Leu Lys Thr Pro Gly Arg Leu Asp His Gly 
    50                  55                  60                  


Thr Arg Thr Ala Phe Ile His His Arg Glu Gln Val Trp Lys Arg Cys 
65                  70                  75                  80  


Ile Asn Ile Trp Arg Asp Val Gly Leu Phe Gly Val Leu Asn Glu Ile 
                85                  90                  95      


Ala Asn Ser Glu Glu Glu Val Phe Glu Trp Val Lys Thr Ala Ser Gly 
            100                 105                 110         


Trp Ala Leu Ala Leu Cys Arg Trp Ala Ser Ser Leu His Gly Ser Leu 
        115                 120                 125             


Phe Pro His Leu Ser Leu Arg Ser Glu Asp Leu Ile Ala Glu Phe Ala 
    130                 135                 140                 


Gln Val Thr Asn Cys Thr Ile Val Pro Ser Leu Lys His Arg Leu Gln 
145                 150                 155                 160 


Arg Asn Val Ala Ser Leu Ala Trp Lys Pro Leu Ser Ala Ser Val Leu 
                165                 170                 175     


Ala Val Ala Cys Gln Ser Cys Ile Leu Ile Trp Thr Leu Asp Pro Thr 
            180                 185                 190         


Ser Leu Ser Thr Arg Pro Ser Ser Gly Cys Ala Gln Val Leu Ser His 
        195                 200                 205             


Pro Gly His Thr Pro Val Thr Ser Leu Ala Trp Ala Pro Ser Gly Gly 
    210                 215                 220                 


Arg Leu Leu Ser Ala Ser Pro Val Asp Ala Ala Ile Arg Val Trp Asp 
225                 230                 235                 240 


Val Ser Thr Glu Thr Cys Val Pro Leu Pro Trp Phe Arg Gly Gly Gly 
                245                 250                 255     


Val Thr Asn Leu Leu Trp Ser Pro Asp Gly Ser Lys Ile Leu Ala Thr 
            260                 265                 270         


Thr Pro Ser Ala Val Phe Arg Val Trp Glu Ala Gln Met Trp Thr Cys 
        275                 280                 285             


Glu Arg Trp Pro Thr Leu Ser Gly Arg Cys Gln Thr Gly Cys Trp Ser 
    290                 295                 300                 


Pro Asp Gly Ser Arg Leu Leu Phe Thr Val Leu Gly Glu Pro Leu Ile 
305                 310                 315                 320 


Tyr Ser Leu Ser Phe Pro Glu Arg Cys Gly Glu Gly Lys Gly Cys Val 
                325                 330                 335     


Gly Gly Ala Lys Ser Ala Thr Ile Val Ala Asp Leu Ser Glu Thr Thr 
            340                 345                 350         


Ile Gln Thr Pro Asp Gly Glu Glu Arg Leu Gly Gly Glu Ala His Ser 
        355                 360                 365             


Met Val Trp Asp Pro Ser Gly Glu Arg Leu Ala Val Leu Met Lys Gly 
    370                 375                 380                 


Lys Pro Arg Val Gln Asp Gly Lys Pro Val Ile Leu Leu Phe Arg Thr 
385                 390                 395                 400 


Arg Asn Ser Pro Val Phe Glu Leu Leu Pro Cys Gly Ile Ile Gln Gly 
                405                 410                 415     


Glu Pro Gly Ala Gln Pro Gln Leu Ile Thr Phe His Pro Ser Phe Asn 
            420                 425                 430         


Lys Gly Ala Leu Leu Ser Val Gly Trp Ser Thr Gly Arg Ile Ala His 
        435                 440                 445             


Ile Pro Leu Tyr Phe Val Asn Ala Gln Phe Pro Arg Phe Ser Pro Val 
    450                 455                 460                 


Leu Gly Arg Ala Gln Glu Pro Pro Ala Gly Gly Gly Gly Ser Ile His 
465                 470                 475                 480 


Asp Leu Pro Leu Phe Thr Glu Thr Ser Pro Thr Ser Ala Pro Trp Asp 
                485                 490                 495     


Pro Leu Pro Gly Pro Pro Pro Val Leu Pro His Ser Pro His Ser His 
            500                 505                 510         


Leu 
    


<210>  19
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AACS__Homo_sapiens__NP_076417

<400>  19

Met Ser Lys Glu Glu Arg Pro Gly Arg Glu Glu Ile Leu Glu Cys Gln 
1               5                   10                  15      


Val Met Trp Glu Pro Asp Ser Lys Lys Asn Thr Gln Met Asp Arg Phe 
            20                  25                  30          


Arg Ala Ala Val Gly Ala Ala Cys Gly Leu Ala Leu Glu Ser Tyr Asp 
        35                  40                  45              


Asp Leu Tyr His Trp Ser Val Glu Ser Tyr Ser Asp Phe Trp Ala Glu 
    50                  55                  60                  


Phe Trp Lys Phe Ser Gly Ile Val Phe Ser Arg Val Tyr Asp Glu Val 
65                  70                  75                  80  


Val Asp Thr Ser Lys Gly Ile Ala Asp Val Pro Glu Trp Phe Lys Gly 
                85                  90                  95      


Ser Arg Leu Asn Tyr Ala Glu Asn Leu Leu Arg His Lys Glu Asn Asp 
            100                 105                 110         


Arg Val Ala Leu Tyr Ile Ala Arg Glu Gly Lys Glu Glu Ile Val Lys 
        115                 120                 125             


Val Thr Phe Glu Glu Leu Arg Gln Glu Val Ala Leu Phe Ala Ala Ala 
    130                 135                 140                 


Met Arg Lys Met Gly Val Lys Lys Gly Asp Arg Val Val Gly Tyr Leu 
145                 150                 155                 160 


Pro Asn Ser Glu His Ala Val Glu Ala Met Leu Ala Ala Ala Ser Ile 
                165                 170                 175     


Gly Ala Ile Trp Ser Ser Thr Ser Pro Asp Phe Gly Val Asn Gly Val 
            180                 185                 190         


Leu Asp Arg Phe Ser Gln Ile Gln Pro Lys Leu Ile Phe Ser Val Glu 
        195                 200                 205             


Ala Val Val Tyr Asn Gly Lys Glu His Asn His Met Glu Lys Leu Gln 
    210                 215                 220                 


Gln Val Val Lys Gly Leu Pro Asp Leu Lys Lys Val Val Val Ile Pro 
225                 230                 235                 240 


Tyr Val Ser Ser Arg Glu Asn Ile Asp Leu Ser Lys Ile Pro Asn Ser 
                245                 250                 255     


Val Phe Leu Asp Asp Phe Leu Ala Thr Gly Thr Ser Glu Gln Ala Pro 
            260                 265                 270         


Gln Leu Glu Phe Glu Gln Leu Pro Phe Ser His Pro Leu Phe Ile Met 
        275                 280                 285             


Phe Ser Ser Gly Thr Thr Gly Ala Pro Lys Cys Met Val His Ser Ala 
    290                 295                 300                 


Gly Gly Thr Leu Ile Gln His Leu Lys Glu His Leu Leu His Gly Asn 
305                 310                 315                 320 


Met Thr Ser Ser Asp Ile Leu Leu Cys Tyr Thr Thr Val Gly Trp Met 
                325                 330                 335     


Met Trp Asn Trp Met Val Ser Leu Leu Ala Thr Gly Ala Ala Met Val 
            340                 345                 350         


Leu Tyr Asp Gly Ser Pro Leu Val Pro Thr Pro Asn Val Leu Trp Asp 
        355                 360                 365             


Leu Val Asp Arg Ile Gly Ile Thr Val Leu Val Thr Gly Ala Lys Trp 
    370                 375                 380                 


Leu Ser Val Leu Glu Glu Lys Ala Met Lys Pro Val Glu Thr His Ser 
385                 390                 395                 400 


Leu Gln Met Leu His Thr Ile Leu Ser Thr Gly Ser Pro Leu Lys Ala 
                405                 410                 415     


Gln Ser Tyr Glu Tyr Val Tyr Arg Cys Ile Lys Ser Ser Ile Leu Leu 
            420                 425                 430         


Gly Ser Ile Ser Gly Gly Thr Asp Ile Ile Ser Cys Phe Met Gly His 
        435                 440                 445             


Asn Phe Ser Leu Pro Val Tyr Lys Gly Glu Ile Gln Ala Arg Asn Leu 
    450                 455                 460                 


Gly Met Ala Val Glu Ala Trp Asn Glu Glu Gly Lys Ala Val Trp Gly 
465                 470                 475                 480 


Glu Ser Gly Glu Leu Val Cys Thr Lys Pro Ile Pro Cys Gln Pro Thr 
                485                 490                 495     


His Phe Trp Asn Asp Glu Asn Gly Asn Lys Tyr Arg Lys Ala Tyr Phe 
            500                 505                 510         


Ser Lys Phe Pro Gly Ile Trp Ala His Gly Asp Tyr Cys Arg Ile Asn 
        515                 520                 525             


Pro Lys Thr Gly Gly Ile Val Met Leu Gly Arg Ser Asp Gly Thr Leu 
    530                 535                 540                 


Asn Pro Asn Gly Val Arg Phe Gly Ser Ser Glu Ile Tyr Asn Ile Val 
545                 550                 555                 560 


Glu Ser Phe Glu Glu Val Glu Asp Ser Leu Cys Val Pro Gln Tyr Asn 
                565                 570                 575     


Lys Tyr Arg Glu Glu Arg Val Ile Leu Phe Leu Lys Met Ala Ser Gly 
            580                 585                 590         


His Ala Phe Gln Pro Asp Leu Val Lys Arg Ile Arg Asp Ala Ile Arg 
        595                 600                 605             


Met Gly Leu Ser Ala Arg His Val Pro Ser Leu Ile Leu Glu Thr Lys 
    610                 615                 620                 


Gly Ile Pro Tyr Thr Leu Asn Gly Lys Lys Val Glu Val Ala Val Lys 
625                 630                 635                 640 


Gln Ile Ile Ala Gly Lys Ala Val Glu Gln Gly Gly Ala Phe Ser Asn 
                645                 650                 655     


Pro Glu Thr Leu Asp Leu Tyr Arg Asp Ile Pro Glu Leu Gln Gly Phe 
            660                 665                 670         


<210>  20
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AADAC__Homo_sapiens__NP_001077

<400>  20

Met Gly Arg Lys Ser Leu Tyr Leu Leu Ile Val Gly Ile Leu Ile Ala 
1               5                   10                  15      


Tyr Tyr Ile Tyr Thr Pro Leu Pro Asp Asn Val Glu Glu Pro Trp Arg 
            20                  25                  30          


Met Met Trp Ile Asn Ala His Leu Lys Thr Ile Gln Asn Leu Ala Thr 
        35                  40                  45              


Phe Val Glu Leu Leu Gly Leu His His Phe Met Asp Ser Phe Lys Val 
    50                  55                  60                  


Val Gly Ser Phe Asp Glu Val Pro Pro Thr Ser Asp Glu Asn Val Thr 
65                  70                  75                  80  


Val Thr Glu Thr Lys Phe Asn Asn Ile Leu Val Arg Val Tyr Val Pro 
                85                  90                  95      


Lys Arg Lys Ser Glu Ala Leu Arg Arg Gly Leu Phe Tyr Ile His Gly 
            100                 105                 110         


Gly Gly Trp Cys Val Gly Ser Ala Ala Leu Ser Gly Tyr Asp Leu Leu 
        115                 120                 125             


Ser Arg Trp Thr Ala Asp Arg Leu Asp Ala Val Val Val Ser Thr Asn 
    130                 135                 140                 


Tyr Arg Leu Ala Pro Lys Tyr His Phe Pro Ile Gln Phe Glu Asp Val 
145                 150                 155                 160 


Tyr Asn Ala Leu Arg Trp Phe Leu Arg Lys Lys Val Leu Ala Lys Tyr 
                165                 170                 175     


Gly Val Asn Pro Glu Arg Ile Gly Ile Ser Gly Asp Ser Ala Gly Gly 
            180                 185                 190         


Asn Leu Ala Ala Ala Val Thr Gln Gln Leu Leu Asp Asp Pro Asp Val 
        195                 200                 205             


Lys Ile Lys Leu Lys Ile Gln Ser Leu Ile Tyr Pro Ala Leu Gln Pro 
    210                 215                 220                 


Leu Asp Val Asp Leu Pro Ser Tyr Gln Glu Asn Ser Asn Phe Leu Phe 
225                 230                 235                 240 


Leu Ser Lys Ser Leu Met Val Arg Phe Trp Ser Glu Tyr Phe Thr Thr 
                245                 250                 255     


Asp Arg Ser Leu Glu Lys Ala Met Leu Ser Arg Gln His Val Pro Val 
            260                 265                 270         


Glu Ser Ser His Leu Phe Lys Phe Val Asn Trp Ser Ser Leu Leu Pro 
        275                 280                 285             


Glu Arg Phe Ile Lys Gly His Val Tyr Asn Asn Pro Asn Tyr Gly Ser 
    290                 295                 300                 


Ser Glu Leu Ala Lys Lys Tyr Pro Gly Phe Leu Asp Val Arg Ala Ala 
305                 310                 315                 320 


Pro Leu Leu Ala Asp Asp Asn Lys Leu Arg Gly Leu Pro Leu Thr Tyr 
                325                 330                 335     


Val Ile Thr Cys Gln Tyr Asp Leu Leu Arg Asp Asp Gly Leu Met Tyr 
            340                 345                 350         


Val Thr Arg Leu Arg Asn Thr Gly Val Gln Val Thr His Asn His Val 
        355                 360                 365             


Glu Asp Gly Phe His Gly Ala Phe Ser Phe Leu Gly Leu Lys Ile Ser 
    370                 375                 380                 


His Arg Leu Ile Asn Gln Tyr Ile Glu Trp Leu Lys Glu Asn Leu 
385                 390                 395                 


<210>  21
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAGAB__Homo_sapiens__NP_078942

<400>  21

Met Ala Ala Gly Val Pro Cys Ala Leu Val Thr Ser Cys Ser Ser Val 
1               5                   10                  15      


Phe Ser Gly Asp Gln Leu Val Gln His Ile Leu Gly Thr Glu Asp Leu 
            20                  25                  30          


Ile Val Glu Val Thr Ser Asn Asp Ala Val Arg Phe Tyr Pro Trp Thr 
        35                  40                  45              


Ile Asp Asn Lys Tyr Tyr Ser Ala Asp Ile Asn Leu Cys Val Val Pro 
    50                  55                  60                  


Asn Lys Phe Leu Val Thr Ala Glu Ile Ala Glu Ser Val Gln Ala Phe 
65                  70                  75                  80  


Val Val Tyr Phe Asp Ser Thr Gln Lys Ser Gly Leu Asp Ser Val Ser 
                85                  90                  95      


Ser Trp Leu Pro Leu Ala Lys Ala Trp Leu Pro Glu Val Met Ile Leu 
            100                 105                 110         


Val Cys Asp Arg Val Ser Glu Asp Gly Ile Asn Arg Gln Lys Ala Gln 
        115                 120                 125             


Glu Trp Cys Ile Lys His Gly Phe Glu Leu Val Glu Leu Ser Pro Glu 
    130                 135                 140                 


Glu Leu Pro Glu Glu Asp Asp Asp Phe Pro Glu Ser Thr Gly Val Lys 
145                 150                 155                 160 


Arg Ile Val Gln Ala Leu Asn Ala Asn Val Trp Ser Asn Val Val Met 
                165                 170                 175     


Lys Asn Asp Arg Asn Gln Gly Phe Ser Leu Leu Asn Ser Leu Thr Gly 
            180                 185                 190         


Thr Asn His Ser Ile Gly Ser Ala Asp Pro Cys His Pro Glu Gln Pro 
        195                 200                 205             


His Leu Pro Ala Ala Asp Ser Thr Glu Ser Leu Ser Asp His Arg Gly 
    210                 215                 220                 


Gly Ala Ser Asn Thr Thr Asp Ala Gln Val Asp Ser Ile Val Asp Pro 
225                 230                 235                 240 


Met Leu Asp Leu Asp Ile Gln Glu Leu Ala Ser Leu Thr Thr Gly Gly 
                245                 250                 255     


Gly Asp Val Glu Asn Phe Glu Arg Leu Phe Ser Lys Leu Lys Glu Met 
            260                 265                 270         


Lys Asp Lys Ala Ala Thr Leu Pro His Glu Gln Arg Lys Val His Ala 
        275                 280                 285             


Glu Lys Val Ala Lys Ala Phe Trp Met Ala Ile Gly Gly Asp Arg Asp 
    290                 295                 300                 


Glu Ile Glu Gly Leu Ser Ser Asp Glu Glu His 
305                 310                 315 


<210>  22
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAK1__Homo_sapiens__NP_055726

<400>  22

Met Lys Lys Phe Phe Asp Ser Arg Arg Glu Gln Gly Gly Ser Gly Leu 
1               5                   10                  15      


Gly Ser Gly Ser Ser Gly Gly Gly Gly Ser Thr Ser Gly Leu Gly Ser 
            20                  25                  30          


Gly Tyr Ile Gly Arg Val Phe Gly Ile Gly Arg Gln Gln Val Thr Val 
        35                  40                  45              


Asp Glu Val Leu Ala Glu Gly Gly Phe Ala Ile Val Phe Leu Val Arg 
    50                  55                  60                  


Thr Ser Asn Gly Met Lys Cys Ala Leu Lys Arg Met Phe Val Asn Asn 
65                  70                  75                  80  


Glu His Asp Leu Gln Val Cys Lys Arg Glu Ile Gln Ile Met Arg Asp 
                85                  90                  95      


Leu Ser Gly His Lys Asn Ile Val Gly Tyr Ile Asp Ser Ser Ile Asn 
            100                 105                 110         


Asn Val Ser Ser Gly Asp Val Trp Glu Val Leu Ile Leu Met Asp Phe 
        115                 120                 125             


Cys Arg Gly Gly Gln Val Val Asn Leu Met Asn Gln Arg Leu Gln Thr 
    130                 135                 140                 


Gly Phe Thr Glu Asn Glu Val Leu Gln Ile Phe Cys Asp Thr Cys Glu 
145                 150                 155                 160 


Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile Ile His Arg Asp 
                165                 170                 175     


Leu Lys Val Glu Asn Ile Leu Leu His Asp Arg Gly His Tyr Val Leu 
            180                 185                 190         


Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Gln Asn Pro Gln Thr Glu 
        195                 200                 205             


Gly Val Asn Ala Val Glu Asp Glu Ile Lys Lys Tyr Thr Thr Leu Ser 
    210                 215                 220                 


Tyr Arg Ala Pro Glu Met Val Asn Leu Tyr Ser Gly Lys Ile Ile Thr 
225                 230                 235                 240 


Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu Tyr Lys Leu Cys 
                245                 250                 255     


Tyr Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala Ile Cys Asp Gly 
            260                 265                 270         


Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Gln Asp Met His Cys 
        275                 280                 285             


Leu Ile Arg Tyr Met Leu Glu Pro Asp Pro Asp Lys Arg Pro Asp Ile 
    290                 295                 300                 


Tyr Gln Val Ser Tyr Phe Ser Phe Lys Leu Leu Lys Lys Glu Cys Pro 
305                 310                 315                 320 


Ile Pro Asn Val Gln Asn Ser Pro Ile Pro Ala Lys Leu Pro Glu Pro 
                325                 330                 335     


Val Lys Ala Ser Glu Ala Ala Ala Lys Lys Thr Gln Pro Lys Ala Arg 
            340                 345                 350         


Leu Thr Asp Pro Ile Pro Thr Thr Glu Thr Ser Ile Ala Pro Arg Gln 
        355                 360                 365             


Arg Pro Lys Ala Gly Gln Thr Gln Pro Asn Pro Gly Ile Leu Pro Ile 
    370                 375                 380                 


Gln Pro Ala Leu Thr Pro Arg Lys Arg Ala Thr Val Gln Pro Pro Pro 
385                 390                 395                 400 


Gln Ala Ala Gly Ser Ser Asn Gln Pro Gly Leu Leu Ala Ser Val Pro 
                405                 410                 415     


Gln Pro Lys Pro Gln Ala Pro Pro Ser Gln Pro Leu Pro Gln Thr Gln 
            420                 425                 430         


Ala Lys Gln Pro Gln Ala Pro Pro Thr Pro Gln Gln Thr Pro Ser Thr 
        435                 440                 445             


Gln Ala Gln Gly Leu Pro Ala Gln Ala Gln Ala Thr Pro Gln His Gln 
    450                 455                 460                 


Gln Gln Leu Phe Leu Lys Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Ala Gln Gln Gln Pro Ala Gly Thr Phe Tyr Gln Gln Gln Gln Ala Gln 
                485                 490                 495     


Thr Gln Gln Phe Gln Ala Val His Pro Ala Thr Gln Gln Pro Ala Ile 
            500                 505                 510         


Ala Gln Phe Pro Val Val Ser Gln Gly Gly Ser Gln Gln Gln Leu Met 
        515                 520                 525             


Gln Asn Phe Tyr Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    530                 535                 540                 


Gln Gln Leu Ala Thr Ala Leu His Gln Gln Gln Leu Met Thr Gln Gln 
545                 550                 555                 560 


Ala Ala Leu Gln Gln Lys Pro Thr Met Ala Ala Gly Gln Gln Pro Gln 
                565                 570                 575     


Pro Gln Pro Ala Ala Ala Pro Gln Pro Ala Pro Ala Gln Glu Pro Ala 
            580                 585                 590         


Ile Gln Ala Pro Val Arg Gln Gln Pro Lys Val Gln Thr Thr Pro Pro 
        595                 600                 605             


Pro Ala Val Gln Gly Gln Lys Val Gly Ser Leu Thr Pro Pro Ser Ser 
    610                 615                 620                 


Pro Lys Thr Gln Arg Ala Gly His Arg Arg Ile Leu Ser Asp Val Thr 
625                 630                 635                 640 


His Ser Ala Val Phe Gly Val Pro Ala Ser Lys Ser Thr Gln Leu Leu 
                645                 650                 655     


Gln Ala Ala Ala Ala Glu Ala Ser Leu Asn Lys Ser Lys Ser Ala Thr 
            660                 665                 670         


Thr Thr Pro Ser Gly Ser Pro Arg Thr Ser Gln Gln Asn Val Tyr Asn 
        675                 680                 685             


Pro Ser Glu Gly Ser Thr Trp Asn Pro Phe Asp Asp Asp Asn Phe Ser 
    690                 695                 700                 


Lys Leu Thr Ala Glu Glu Leu Leu Asn Lys Asp Phe Ala Lys Leu Gly 
705                 710                 715                 720 


Glu Gly Lys His Pro Glu Lys Leu Gly Gly Ser Ala Glu Ser Leu Ile 
                725                 730                 735     


Pro Gly Phe Gln Ser Thr Gln Gly Asp Ala Phe Ala Thr Thr Ser Phe 
            740                 745                 750         


Ser Ala Gly Thr Ala Glu Lys Arg Lys Gly Gly Gln Thr Val Asp Ser 
        755                 760                 765             


Gly Leu Pro Leu Leu Ser Val Ser Asp Pro Phe Ile Pro Leu Gln Val 
    770                 775                 780                 


Pro Asp Ala Pro Glu Lys Leu Ile Glu Gly Leu Lys Ser Pro Asp Thr 
785                 790                 795                 800 


Ser Leu Leu Leu Pro Asp Leu Leu Pro Met Thr Asp Pro Phe Gly Ser 
                805                 810                 815     


Thr Ser Asp Ala Val Ile Glu Lys Ala Asp Val Ala Val Glu Ser Leu 
            820                 825                 830         


Ile Pro Gly Leu Glu Pro Pro Val Pro Gln Arg Leu Pro Ser Gln Thr 
        835                 840                 845             


Glu Ser Val Thr Ser Asn Arg Thr Asp Ser Leu Thr Gly Glu Asp Ser 
    850                 855                 860                 


Leu Leu Asp Cys Ser Leu Leu Ser Asn Pro Thr Thr Asp Leu Leu Glu 
865                 870                 875                 880 


Glu Phe Ala Pro Thr Ala Ile Ser Ala Pro Val His Lys Ala Ala Glu 
                885                 890                 895     


Asp Ser Asn Leu Ile Ser Gly Phe Asp Val Pro Glu Gly Ser Asp Lys 
            900                 905                 910         


Val Ala Glu Asp Glu Phe Asp Pro Ile Pro Val Leu Ile Thr Lys Asn 
        915                 920                 925             


Pro Gln Gly Gly His Ser Arg Asn Ser Ser Gly Ser Ser Glu Ser Ser 
    930                 935                 940                 


Leu Pro Asn Leu Ala Arg Ser Leu Leu Leu Val Asp Gln Leu Ile Asp 
945                 950                 955                 960 


Leu 
    


<210>  23
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AANAT__Homo_sapiens__NP_001160051

<400>  23

Met Glu Pro Gln Ser Met Lys Gly Gln Lys Arg Pro Phe Gly Gly Pro 
1               5                   10                  15      


Trp Arg Leu Lys Val Leu Gly Gly Pro Pro Trp Leu Arg Arg Thr Leu 
            20                  25                  30          


Pro Lys Leu Gly Arg Pro Lys Glu Ala Pro Val Ala Arg Met Ser Thr 
        35                  40                  45              


Gln Ser Thr His Pro Leu Lys Pro Glu Ala Pro Arg Leu Pro Pro Gly 
    50                  55                  60                  


Ile Pro Glu Ser Pro Ser Cys Gln Arg Arg His Thr Leu Pro Ala Ser 
65                  70                  75                  80  


Glu Phe Arg Cys Leu Thr Pro Glu Asp Ala Val Ser Ala Phe Glu Ile 
                85                  90                  95      


Glu Arg Glu Ala Phe Ile Ser Val Leu Gly Val Cys Pro Leu Tyr Leu 
            100                 105                 110         


Asp Glu Ile Arg His Phe Leu Thr Leu Cys Pro Glu Leu Ser Leu Gly 
        115                 120                 125             


Trp Phe Glu Glu Gly Cys Leu Val Ala Phe Ile Ile Gly Ser Leu Trp 
    130                 135                 140                 


Asp Lys Glu Arg Leu Met Gln Glu Ser Leu Thr Leu His Arg Ser Gly 
145                 150                 155                 160 


Gly His Ile Ala His Leu His Val Leu Ala Val His Arg Ala Phe Arg 
                165                 170                 175     


Gln Gln Gly Arg Gly Pro Ile Leu Leu Trp Arg Tyr Leu His His Leu 
            180                 185                 190         


Gly Ser Gln Pro Ala Val Arg Arg Ala Ala Leu Met Cys Glu Asp Ala 
        195                 200                 205             


Leu Val Pro Phe Tyr Glu Arg Phe Ser Phe His Ala Val Gly Pro Cys 
    210                 215                 220                 


Ala Ile Thr Val Gly Ser Leu Thr Phe Met Glu Leu His Cys Ser Leu 
225                 230                 235                 240 


Arg Gly His Pro Phe Leu Arg Arg Asn Ser Gly Cys 
                245                 250         


<210>  24
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AARD__Homo_sapiens__NP_001020528

<400>  24

Met Gly Pro Gly Asp Phe Arg Arg Cys Arg Glu Arg Ile Ser Gln Gly 
1               5                   10                  15      


Leu Gln Gly Leu Pro Gly Arg Ala Glu Leu Trp Phe Pro Pro Arg Pro 
            20                  25                  30          


Ala Cys Asp Phe Phe Gly Asp Gly Arg Ser Thr Asp Ile Gln Glu Glu 
        35                  40                  45              


Ala Leu Ala Ala Ser Pro Leu Leu Glu Asp Leu Arg Arg Arg Leu Thr 
    50                  55                  60                  


Arg Ala Phe Gln Trp Ala Val Gln Arg Ala Ile Ser Arg Arg Val Gln 
65                  70                  75                  80  


Glu Ala Ala Ala Ala Ala Ala Ala Arg Glu Glu Gln Ser Trp Thr Gly 
                85                  90                  95      


Val Glu Ala Thr Leu Ala Arg Leu Arg Ala Glu Leu Val Glu Met His 
            100                 105                 110         


Phe Gln Asn His Gln Leu Ala Arg Thr Leu Leu Asp Leu Asn Met Lys 
        115                 120                 125             


Val Gln Gln Leu Lys Lys Glu Tyr Glu Leu Glu Ile Thr Ser Asp Ser 
    130                 135                 140                 


Gln Ser Pro Lys Asp Asp Ala Ala Asn Pro Glu 
145                 150                 155 


<210>  25
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AARS2__Homo_sapiens__NP_065796

<400>  25

Met Ala Ala Ser Val Ala Ala Ala Ala Arg Arg Leu Arg Arg Ala Ile 
1               5                   10                  15      


Arg Arg Ser Pro Ala Trp Arg Gly Leu Ser His Arg Pro Leu Ser Ser 
            20                  25                  30          


Glu Pro Pro Ala Ala Lys Ala Ser Ala Val Arg Ala Ala Phe Leu Asn 
        35                  40                  45              


Phe Phe Arg Asp Arg His Gly His Arg Leu Val Pro Ser Ala Ser Val 
    50                  55                  60                  


Arg Pro Arg Gly Asp Pro Ser Leu Leu Phe Val Asn Ala Gly Met Asn 
65                  70                  75                  80  


Gln Phe Lys Pro Ile Phe Leu Gly Thr Val Asp Pro Arg Ser Glu Met 
                85                  90                  95      


Ala Gly Phe Arg Arg Val Ala Asn Ser Gln Lys Cys Val Arg Ala Gly 
            100                 105                 110         


Gly His His Asn Asp Leu Glu Asp Val Gly Arg Asp Leu Ser His His 
        115                 120                 125             


Thr Phe Phe Glu Met Leu Gly Asn Trp Ala Phe Gly Gly Glu Tyr Phe 
    130                 135                 140                 


Lys Glu Glu Ala Cys Asn Met Ala Trp Glu Leu Leu Thr Gln Val Tyr 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Arg Leu Trp Ile Ser Tyr Phe Asp Gly Asp Pro 
                165                 170                 175     


Lys Ala Gly Leu Asp Pro Asp Leu Glu Thr Arg Asp Ile Trp Leu Ser 
            180                 185                 190         


Leu Gly Val Pro Ala Ser Arg Val Leu Ser Phe Gly Pro Gln Glu Asn 
        195                 200                 205             


Phe Trp Glu Met Gly Asp Thr Gly Pro Cys Gly Pro Cys Thr Glu Ile 
    210                 215                 220                 


His Tyr Asp Leu Ala Gly Gly Val Gly Ala Pro Gln Leu Val Glu Leu 
225                 230                 235                 240 


Trp Asn Leu Val Phe Met Gln His Asn Arg Glu Ala Asp Gly Ser Leu 
                245                 250                 255     


Gln Pro Leu Pro Gln Arg His Val Asp Thr Gly Met Gly Leu Glu Arg 
            260                 265                 270         


Leu Val Ala Val Leu Gln Gly Lys His Ser Thr Tyr Asp Thr Asp Leu 
        275                 280                 285             


Phe Ser Pro Leu Leu Asn Ala Ile Gln Gln Gly Cys Arg Ala Pro Pro 
    290                 295                 300                 


Tyr Leu Gly Arg Val Gly Val Ala Asp Glu Gly Arg Thr Asp Thr Ala 
305                 310                 315                 320 


Tyr Arg Val Val Ala Asp His Ile Arg Thr Leu Ser Val Cys Ile Ser 
                325                 330                 335     


Asp Gly Val Phe Pro Gly Met Ser Gly Pro Pro Leu Val Leu Arg Arg 
            340                 345                 350         


Ile Leu Arg Arg Ala Val Arg Phe Ser Met Glu Ile Leu Lys Ala Pro 
        355                 360                 365             


Pro Gly Phe Leu Gly Ser Leu Val Pro Val Val Val Glu Thr Leu Gly 
    370                 375                 380                 


Asp Ala Tyr Pro Glu Leu Gln Arg Asn Ser Ala Gln Ile Ala Asn Leu 
385                 390                 395                 400 


Val Ser Glu Asp Glu Ala Ala Phe Leu Ala Ser Leu Glu Arg Gly Arg 
                405                 410                 415     


Arg Ile Ile Asp Arg Thr Leu Arg Thr Leu Gly Pro Ser Asp Met Phe 
            420                 425                 430         


Pro Ala Glu Val Ala Trp Ser Leu Ser Leu Cys Gly Asp Leu Gly Leu 
        435                 440                 445             


Pro Leu Asp Met Val Glu Leu Met Leu Glu Glu Lys Gly Val Gln Leu 
    450                 455                 460                 


Asp Ser Ala Gly Leu Glu Arg Leu Ala Gln Glu Glu Ala Gln His Arg 
465                 470                 475                 480 


Ala Arg Gln Ala Glu Pro Val Gln Lys Gln Gly Leu Trp Leu Asp Val 
                485                 490                 495     


His Ala Leu Gly Glu Leu Gln Arg Gln Gly Val Pro Pro Thr Asp Asp 
            500                 505                 510         


Ser Pro Lys Tyr Asn Tyr Ser Leu Arg Pro Ser Gly Ser Tyr Glu Phe 
        515                 520                 525             


Gly Thr Cys Glu Ala Gln Val Leu Gln Leu Tyr Thr Glu Asp Gly Thr 
    530                 535                 540                 


Ala Val Ala Ser Val Gly Lys Gly Gln Arg Cys Gly Leu Leu Leu Asp 
545                 550                 555                 560 


Arg Thr Asn Phe Tyr Ala Glu Gln Gly Gly Gln Ala Ser Asp Arg Gly 
                565                 570                 575     


Tyr Leu Val Arg Ala Gly Gln Glu Asp Val Leu Phe Pro Val Ala Arg 
            580                 585                 590         


Ala Gln Val Cys Gly Gly Phe Ile Leu His Glu Ala Val Ala Pro Glu 
        595                 600                 605             


Cys Leu Arg Leu Gly Asp Gln Val Gln Leu His Val Asp Glu Ala Trp 
    610                 615                 620                 


Arg Leu Gly Cys Met Ala Lys His Thr Ala Thr His Leu Leu Asn Trp 
625                 630                 635                 640 


Ala Leu Arg Gln Thr Leu Gly Pro Gly Thr Glu Gln Gln Gly Ser His 
                645                 650                 655     


Leu Asn Pro Glu Gln Leu Arg Leu Asp Val Thr Thr Gln Thr Pro Leu 
            660                 665                 670         


Thr Pro Glu Gln Leu Arg Ala Val Glu Asn Thr Val Gln Glu Ala Val 
        675                 680                 685             


Gly Gln Asp Glu Ala Val Tyr Met Glu Glu Val Pro Leu Ala Leu Thr 
    690                 695                 700                 


Ala Gln Val Pro Gly Leu Arg Ser Leu Asp Glu Val Tyr Pro Asp Pro 
705                 710                 715                 720 


Val Arg Val Val Ser Val Gly Val Pro Val Ala His Ala Leu Asp Pro 
                725                 730                 735     


Ala Ser Gln Ala Ala Leu Gln Thr Ser Val Glu Leu Cys Cys Gly Thr 
            740                 745                 750         


His Leu Leu Arg Thr Gly Ala Val Gly Asp Leu Val Ile Ile Gly Asp 
        755                 760                 765             


Arg Gln Leu Ser Lys Gly Thr Thr Arg Leu Leu Ala Val Thr Gly Glu 
    770                 775                 780                 


Gln Ala Gln Gln Ala Arg Glu Leu Gly Gln Ser Leu Ala Gln Glu Val 
785                 790                 795                 800 


Lys Ala Ala Thr Glu Arg Leu Ser Leu Gly Ser Arg Asp Val Ala Glu 
                805                 810                 815     


Ala Leu Arg Leu Ser Lys Asp Ile Gly Arg Leu Ile Glu Ala Val Glu 
            820                 825                 830         


Thr Ala Val Met Pro Gln Trp Gln Arg Arg Glu Leu Leu Ala Thr Val 
        835                 840                 845             


Lys Met Leu Gln Arg Arg Ala Asn Thr Ala Ile Arg Lys Leu Gln Met 
    850                 855                 860                 


Gly Gln Ala Ala Lys Lys Thr Gln Glu Leu Leu Glu Arg His Ser Lys 
865                 870                 875                 880 


Gly Pro Leu Ile Val Asp Thr Val Ser Ala Glu Ser Leu Ser Val Leu 
                885                 890                 895     


Val Lys Val Val Arg Gln Leu Cys Glu Gln Ala Pro Ser Thr Ser Val 
            900                 905                 910         


Leu Leu Leu Ser Pro Gln Pro Met Gly Lys Val Leu Cys Ala Cys Gln 
        915                 920                 925             


Val Ala Gln Gly Ala Met Pro Thr Phe Thr Ala Glu Ala Trp Ala Leu 
    930                 935                 940                 


Ala Val Cys Ser His Met Gly Gly Lys Ala Trp Gly Ser Arg Val Val 
945                 950                 955                 960 


Ala Gln Gly Thr Gly Ser Thr Thr Asp Leu Glu Ala Ala Leu Ser Ile 
                965                 970                 975     


Ala Gln Thr Tyr Ala Leu Ser Gln Leu 
            980                 985 


<210>  26
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AARS__Homo_sapiens__NP_001596

<400>  26

Met Asp Ser Thr Leu Thr Ala Ser Glu Ile Arg Gln Arg Phe Ile Asp 
1               5                   10                  15      


Phe Phe Lys Arg Asn Glu His Thr Tyr Val His Ser Ser Ala Thr Ile 
            20                  25                  30          


Pro Leu Asp Asp Pro Thr Leu Leu Phe Ala Asn Ala Gly Met Asn Gln 
        35                  40                  45              


Phe Lys Pro Ile Phe Leu Asn Thr Ile Asp Pro Ser His Pro Met Ala 
    50                  55                  60                  


Lys Leu Ser Arg Ala Ala Asn Thr Gln Lys Cys Ile Arg Ala Gly Gly 
65                  70                  75                  80  


Lys His Asn Asp Leu Asp Asp Val Gly Lys Asp Val Tyr His His Thr 
                85                  90                  95      


Phe Phe Glu Met Leu Gly Ser Trp Ser Phe Gly Asp Tyr Phe Lys Glu 
            100                 105                 110         


Leu Ala Cys Lys Met Ala Leu Glu Leu Leu Thr Gln Glu Phe Gly Ile 
        115                 120                 125             


Pro Ile Glu Arg Leu Tyr Val Thr Tyr Phe Gly Gly Asp Glu Ala Ala 
    130                 135                 140                 


Gly Leu Glu Ala Asp Leu Glu Cys Lys Gln Ile Trp Gln Asn Leu Gly 
145                 150                 155                 160 


Leu Asp Asp Thr Lys Ile Leu Pro Gly Asn Met Lys Asp Asn Phe Trp 
                165                 170                 175     


Glu Met Gly Asp Thr Gly Pro Cys Gly Pro Cys Ser Glu Ile His Tyr 
            180                 185                 190         


Asp Arg Ile Gly Gly Arg Asp Ala Ala His Leu Val Asn Gln Asp Asp 
        195                 200                 205             


Pro Asn Val Leu Glu Ile Trp Asn Leu Val Phe Ile Gln Tyr Asn Arg 
    210                 215                 220                 


Glu Ala Asp Gly Ile Leu Lys Pro Leu Pro Lys Lys Ser Ile Asp Thr 
225                 230                 235                 240 


Gly Met Gly Leu Glu Arg Leu Val Ser Val Leu Gln Asn Lys Met Ser 
                245                 250                 255     


Asn Tyr Asp Thr Asp Leu Phe Val Pro Tyr Phe Glu Ala Ile Gln Lys 
            260                 265                 270         


Gly Thr Gly Ala Arg Pro Tyr Thr Gly Lys Val Gly Ala Glu Asp Ala 
        275                 280                 285             


Asp Gly Ile Asp Met Ala Tyr Arg Val Leu Ala Asp His Ala Arg Thr 
    290                 295                 300                 


Ile Thr Val Ala Leu Ala Asp Gly Gly Arg Pro Asp Asn Thr Gly Arg 
305                 310                 315                 320 


Gly Tyr Val Leu Arg Arg Ile Leu Arg Arg Ala Val Arg Tyr Ala His 
                325                 330                 335     


Glu Lys Leu Asn Ala Ser Arg Gly Phe Phe Ala Thr Leu Val Asp Val 
            340                 345                 350         


Val Val Gln Ser Leu Gly Asp Ala Phe Pro Glu Leu Lys Lys Asp Pro 
        355                 360                 365             


Asp Met Val Lys Asp Ile Ile Asn Glu Glu Glu Val Gln Phe Leu Lys 
    370                 375                 380                 


Thr Leu Ser Arg Gly Arg Arg Ile Leu Asp Arg Lys Ile Gln Ser Leu 
385                 390                 395                 400 


Gly Asp Ser Lys Thr Ile Pro Gly Asp Thr Ala Trp Leu Leu Tyr Asp 
                405                 410                 415     


Thr Tyr Gly Phe Pro Val Asp Leu Thr Gly Leu Ile Ala Glu Glu Lys 
            420                 425                 430         


Gly Leu Val Val Asp Met Asp Gly Phe Glu Glu Glu Arg Lys Leu Ala 
        435                 440                 445             


Gln Leu Lys Ser Gln Gly Lys Gly Ala Gly Gly Glu Asp Leu Ile Met 
    450                 455                 460                 


Leu Asp Ile Tyr Ala Ile Glu Glu Leu Arg Ala Arg Gly Leu Glu Val 
465                 470                 475                 480 


Thr Asp Asp Ser Pro Lys Tyr Asn Tyr His Leu Asp Ser Ser Gly Ser 
                485                 490                 495     


Tyr Val Phe Glu Asn Thr Val Ala Thr Val Met Ala Leu Arg Arg Glu 
            500                 505                 510         


Lys Met Phe Val Glu Glu Val Ser Thr Gly Gln Glu Cys Gly Val Val 
        515                 520                 525             


Leu Asp Lys Thr Cys Phe Tyr Ala Glu Gln Gly Gly Gln Ile Tyr Asp 
    530                 535                 540                 


Glu Gly Tyr Leu Val Lys Val Asp Asp Ser Ser Glu Asp Lys Thr Glu 
545                 550                 555                 560 


Phe Thr Val Lys Asn Ala Gln Val Arg Gly Gly Tyr Val Leu His Ile 
                565                 570                 575     


Gly Thr Ile Tyr Gly Asp Leu Lys Val Gly Asp Gln Val Trp Leu Phe 
            580                 585                 590         


Ile Asp Glu Pro Arg Arg Arg Pro Ile Met Ser Asn His Thr Ala Thr 
        595                 600                 605             


His Ile Leu Asn Phe Ala Leu Arg Ser Val Leu Gly Glu Ala Asp Gln 
    610                 615                 620                 


Lys Gly Ser Leu Val Ala Pro Asp Arg Leu Arg Phe Asp Phe Thr Ala 
625                 630                 635                 640 


Lys Gly Ala Met Ser Thr Gln Gln Ile Lys Lys Ala Glu Glu Ile Ala 
                645                 650                 655     


Asn Glu Met Ile Glu Ala Ala Lys Ala Val Tyr Thr Gln Asp Cys Pro 
            660                 665                 670         


Leu Ala Ala Ala Lys Ala Ile Gln Gly Leu Arg Ala Val Phe Asp Glu 
        675                 680                 685             


Thr Tyr Pro Asp Pro Val Arg Val Val Ser Ile Gly Val Pro Val Ser 
    690                 695                 700                 


Glu Leu Leu Asp Asp Pro Ser Gly Pro Ala Gly Ser Leu Thr Ser Val 
705                 710                 715                 720 


Glu Phe Cys Gly Gly Thr His Leu Arg Asn Ser Ser His Ala Gly Ala 
                725                 730                 735     


Phe Val Ile Val Thr Glu Glu Ala Ile Ala Lys Gly Ile Arg Arg Ile 
            740                 745                 750         


Val Ala Val Thr Gly Ala Glu Ala Gln Lys Ala Leu Arg Lys Ala Glu 
        755                 760                 765             


Ser Leu Lys Lys Cys Leu Ser Val Met Glu Ala Lys Val Lys Ala Gln 
    770                 775                 780                 


Thr Ala Pro Asn Lys Asp Val Gln Arg Glu Ile Ala Asp Leu Gly Glu 
785                 790                 795                 800 


Ala Leu Ala Thr Ala Val Ile Pro Gln Trp Gln Lys Asp Glu Leu Arg 
                805                 810                 815     


Glu Thr Leu Lys Ser Leu Lys Lys Val Met Asp Asp Leu Asp Arg Ala 
            820                 825                 830         


Ser Lys Ala Asp Val Gln Lys Arg Val Leu Glu Lys Thr Lys Gln Phe 
        835                 840                 845             


Ile Asp Ser Asn Pro Asn Gln Pro Leu Val Ile Leu Glu Met Glu Ser 
    850                 855                 860                 


Gly Ala Ser Ala Lys Ala Leu Asn Glu Ala Leu Lys Leu Phe Lys Met 
865                 870                 875                 880 


His Ser Pro Gln Thr Ser Ala Met Leu Phe Thr Val Asp Asn Glu Ala 
                885                 890                 895     


Gly Lys Ile Thr Cys Leu Cys Gln Val Pro Gln Asn Ala Ala Asn Arg 
            900                 905                 910         


Gly Leu Lys Ala Ser Glu Trp Val Gln Gln Val Ser Gly Leu Met Asp 
        915                 920                 925             


Gly Lys Gly Gly Gly Lys Asp Val Ser Ala Gln Ala Thr Gly Lys Asn 
    930                 935                 940                 


Val Gly Cys Leu Gln Glu Ala Leu Gln Leu Ala Thr Ser Phe Ala Gln 
945                 950                 955                 960 


Leu Arg Leu Gly Asp Val Lys Asn 
                965             


<210>  27
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AASDH__Homo_sapiens__NP_001273597

<400>  27

Met Lys Lys Cys Asn Leu Lys Tyr Ile Leu Val Glu Lys Lys Gln Ile 
1               5                   10                  15      


Asn Lys Phe Lys Ser Phe His Glu Thr Leu Leu Asn Tyr Asp Thr Phe 
            20                  25                  30          


Thr Val Glu His Asn Asp Leu Val Leu Phe Arg Leu His Trp Lys Asn 
        35                  40                  45              


Thr Glu Val Asn Leu Met Leu Asn Asp Gly Lys Glu Lys Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ile Lys Ser Ile Ser Ser Glu His Val Asn Glu Glu Lys Ala 
65                  70                  75                  80  


Glu Glu His Met Asp Leu Arg Leu Lys His Cys Leu Ala Tyr Val Leu 
                85                  90                  95      


His Thr Ser Gly Thr Thr Gly Ile Pro Lys Ile Val Arg Val Pro His 
            100                 105                 110         


Lys Cys Ile Val Pro Asn Ile Gln His Phe Arg Val Leu Phe Asp Ile 
        115                 120                 125             


Thr Gln Glu Asp Val Leu Phe Leu Ala Ser Pro Leu Thr Phe Asp Pro 
    130                 135                 140                 


Ser Val Val Glu Ile Phe Leu Ala Leu Ser Ser Gly Ala Ser Leu Leu 
145                 150                 155                 160 


Ile Val Pro Thr Ser Val Lys Leu Leu Pro Ser Lys Leu Ala Ser Val 
                165                 170                 175     


Leu Phe Ser His His Arg Val Thr Val Leu Gln Ala Thr Pro Thr Leu 
            180                 185                 190         


Leu Arg Arg Phe Gly Ser Gln Leu Ile Lys Ser Thr Val Leu Ser Ala 
        195                 200                 205             


Thr Thr Ser Leu Arg Val Leu Ala Leu Gly Gly Glu Ala Phe Pro Ser 
    210                 215                 220                 


Leu Thr Val Leu Arg Ser Trp Arg Gly Glu Gly Asn Lys Thr Gln Ile 
225                 230                 235                 240 


Phe Asn Val Tyr Gly Ile Thr Glu Val Ser Ser Trp Ala Thr Ile Tyr 
                245                 250                 255     


Arg Ile Pro Glu Lys Thr Leu Asn Ser Thr Leu Lys Cys Glu Leu Pro 
            260                 265                 270         


Val Gln Leu Gly Phe Pro Leu Leu Gly Thr Val Val Glu Val Arg Asp 
        275                 280                 285             


Thr Asn Gly Phe Thr Ile Gln Glu Gly Ser Gly Gln Val Phe Leu Gly 
    290                 295                 300                 


Gly Arg Asn Arg Val Cys Phe Leu Asp Asp Glu Val Thr Val Pro Leu 
305                 310                 315                 320 


Gly Thr Met Arg Ala Thr Gly Asp Phe Val Thr Val Lys Asp Gly Glu 
                325                 330                 335     


Ile Phe Phe Leu Gly Arg Lys Asp Ser Gln Ile Lys Arg His Gly Lys 
            340                 345                 350         


Arg Leu Asn Ile Glu Leu Val Gln Gln Val Ala Glu Glu Leu Gln Gln 
        355                 360                 365             


Val Glu Ser Cys Ala Val Thr Trp Tyr Asn Gln Glu Lys Leu Ile Leu 
    370                 375                 380                 


Phe Met Val Ser Lys Asp Ala Ser Val Lys Glu Tyr Ile Phe Lys Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Leu Pro Ser His Ala Val Pro Asp Glu Leu Val Leu 
                405                 410                 415     


Ile Asp Ser Leu Pro Phe Thr Ser His Gly Lys Ile Asp Val Ser Glu 
            420                 425                 430         


Leu Asn Lys Ile Tyr Leu Asn Tyr Ile Asn Leu Lys Ser Glu Asn Lys 
        435                 440                 445             


Leu Ser Gly Lys Glu Asp Leu Trp Glu Lys Leu Gln Tyr Leu Trp Lys 
    450                 455                 460                 


Ser Thr Leu Asn Leu Pro Glu Asp Leu Leu Arg Val Pro Asp Glu Ser 
465                 470                 475                 480 


Leu Phe Leu Asn Ser Gly Gly Asp Ser Leu Lys Ser Ile Arg Leu Leu 
                485                 490                 495     


Ser Glu Ile Glu Lys Leu Val Gly Thr Ser Val Pro Gly Leu Leu Glu 
            500                 505                 510         


Ile Ile Leu Ser Ser Ser Ile Leu Glu Ile Tyr Asn His Ile Leu Gln 
        515                 520                 525             


Thr Val Val Pro Asp Glu Asp Val Thr Phe Arg Lys Ser Cys Ala Thr 
    530                 535                 540                 


Lys Arg Lys Leu Ser Asp Ile Asn Gln Glu Glu Ala Ser Gly Thr Ser 
545                 550                 555                 560 


Leu His Gln Lys Ala Ile Met Thr Phe Thr Cys His Asn Glu Ile Asn 
                565                 570                 575     


Ala Phe Val Val Leu Ser Arg Gly Ser Gln Ile Leu Ser Leu Asn Ser 
            580                 585                 590         


Thr Arg Phe Leu Thr Lys Leu Gly His Cys Ser Ser Ala Cys Pro Ser 
        595                 600                 605             


Asp Ser Val Ser Gln Thr Asn Ile Gln Asn Leu Lys Gly Leu Asn Ser 
    610                 615                 620                 


Pro Val Leu Ile Gly Lys Ser Lys Asp Pro Ser Cys Val Ala Lys Val 
625                 630                 635                 640 


Ser Glu Glu Gly Lys Pro Ala Ile Gly Thr Gln Lys Met Glu Leu His 
                645                 650                 655     


Val Arg Trp Arg Ser Asp Thr Gly Lys Cys Val Asp Ala Ser Pro Leu 
            660                 665                 670         


Val Val Ile Pro Thr Phe Asp Lys Ser Ser Thr Thr Val Tyr Ile Gly 
        675                 680                 685             


Ser His Ser His Arg Met Lys Ala Val Asp Phe Tyr Ser Gly Lys Val 
    690                 695                 700                 


Lys Trp Glu Gln Ile Leu Gly Asp Arg Ile Glu Ser Ser Ala Cys Val 
705                 710                 715                 720 


Ser Lys Cys Gly Asn Phe Ile Val Val Gly Cys Tyr Asn Gly Leu Val 
                725                 730                 735     


Tyr Val Leu Lys Ser Asn Ser Gly Glu Lys Tyr Trp Met Phe Thr Thr 
            740                 745                 750         


Glu Asp Ala Val Lys Ser Ser Ala Thr Met Asp Pro Thr Thr Gly Leu 
        755                 760                 765             


Ile Tyr Ile Gly Ser His Asp Gln His Ala Tyr Ala Leu Asp Ile Tyr 
    770                 775                 780                 


Arg Lys Lys Cys Val Trp Lys Ser Lys Cys Gly Gly Thr Val Phe Ser 
785                 790                 795                 800 


Ser Pro Cys Leu Asn Leu Ile Pro His His Leu Tyr Phe Ala Thr Leu 
                805                 810                 815     


Gly Gly Leu Leu Leu Ala Val Asn Pro Ala Thr Gly Asn Val Ile Trp 
            820                 825                 830         


Lys His Ser Cys Gly Lys Pro Leu Phe Ser Ser Pro Gln Cys Cys Ser 
        835                 840                 845             


Gln Tyr Ile Cys Ile Gly Cys Val Asp Gly Asn Leu Leu Cys Phe Thr 
    850                 855                 860                 


His Phe Gly Glu Gln Val Trp Gln Phe Ser Thr Ser Gly Pro Ile Phe 
865                 870                 875                 880 


Ser Ser Pro Cys Thr Ser Pro Ser Glu Gln Lys Ile Phe Phe Gly Ser 
                885                 890                 895     


His Asp Cys Phe Ile Tyr Cys Cys Asn Met Lys Gly His Leu Gln Trp 
            900                 905                 910         


Lys Phe Glu Thr Thr Ser Arg Val Tyr Ala Thr Pro Phe Ala Phe His 
        915                 920                 925             


Asn Tyr Asn Gly Ser Asn Glu Met Leu Leu Ala Ala Ala Ser Thr Asp 
    930                 935                 940                 


Gly Lys Val Trp Ile Leu Glu Ser Gln Ser Gly Gln Leu Gln Ser Val 
945                 950                 955                 960 


Tyr Glu Leu Pro Gly Glu Val Phe Ser Ser Pro Val Val Leu Glu Ser 
                965                 970                 975     


Met Leu Ile Ile Gly Cys Arg Asp Asn Tyr Val Tyr Cys Leu Asp Leu 
            980                 985                 990         


Leu Gly Gly Asn Gln Lys 
        995             


<210>  28
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AASDHPPT__Homo_sapiens__NP_056238

<400>  28

Met Val Phe Pro Ala Lys Arg Phe Cys Leu Val Pro Ser Met Glu Gly 
1               5                   10                  15      


Val Arg Trp Ala Phe Ser Cys Gly Thr Trp Leu Pro Ser Arg Ala Glu 
            20                  25                  30          


Trp Leu Leu Ala Val Arg Ser Ile Gln Pro Glu Glu Lys Glu Arg Ile 
        35                  40                  45              


Gly Gln Phe Val Phe Ala Arg Asp Ala Lys Ala Ala Met Ala Gly Arg 
    50                  55                  60                  


Leu Met Ile Arg Lys Leu Val Ala Glu Lys Leu Asn Ile Pro Trp Asn 
65                  70                  75                  80  


His Ile Arg Leu Gln Arg Thr Ala Lys Gly Lys Pro Val Leu Ala Lys 
                85                  90                  95      


Asp Ser Ser Asn Pro Tyr Pro Asn Phe Asn Phe Asn Ile Ser His Gln 
            100                 105                 110         


Gly Asp Tyr Ala Val Leu Ala Ala Glu Pro Glu Leu Gln Val Gly Ile 
        115                 120                 125             


Asp Ile Met Lys Thr Ser Phe Pro Gly Arg Gly Ser Ile Pro Glu Phe 
    130                 135                 140                 


Phe His Ile Met Lys Arg Lys Phe Thr Asn Lys Glu Trp Glu Thr Ile 
145                 150                 155                 160 


Arg Ser Phe Lys Asp Glu Trp Thr Gln Leu Asp Met Phe Tyr Arg Asn 
                165                 170                 175     


Trp Ala Leu Lys Glu Ser Phe Ile Lys Ala Ile Gly Val Gly Leu Gly 
            180                 185                 190         


Phe Glu Leu Gln Arg Leu Glu Phe Asp Leu Ser Pro Leu Asn Leu Asp 
        195                 200                 205             


Ile Gly Gln Val Tyr Lys Glu Thr Arg Leu Phe Leu Asp Gly Glu Glu 
    210                 215                 220                 


Glu Lys Glu Trp Ala Phe Glu Glu Ser Lys Ile Asp Glu His His Phe 
225                 230                 235                 240 


Val Ala Val Ala Leu Arg Lys Pro Asp Gly Ser Arg His Gln Asp Val 
                245                 250                 255     


Pro Ser Gln Asp Asp Ser Lys Pro Thr Gln Arg Gln Phe Thr Ile Leu 
            260                 265                 270         


Asn Phe Asn Asp Leu Met Ser Ser Ala Val Pro Met Thr Pro Glu Asp 
        275                 280                 285             


Pro Ser Phe Trp Asp Cys Phe Cys Phe Thr Glu Glu Ile Pro Ile Arg 
    290                 295                 300                 


Asn Gly Thr Lys Ser 
305                 


<210>  29
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AASS__Homo_sapiens__NP_005754

<400>  29

Met Leu Gln Val His Arg Thr Gly Leu Gly Arg Leu Gly Val Ser Leu 
1               5                   10                  15      


Ser Lys Gly Leu His His Lys Ala Val Leu Ala Val Arg Arg Glu Asp 
            20                  25                  30          


Val Asn Ala Trp Glu Arg Arg Ala Pro Leu Ala Pro Lys His Ile Lys 
        35                  40                  45              


Gly Ile Thr Asn Leu Gly Tyr Lys Val Leu Ile Gln Pro Ser Asn Arg 
    50                  55                  60                  


Arg Ala Ile His Asp Lys Asp Tyr Val Lys Ala Gly Gly Ile Leu Gln 
65                  70                  75                  80  


Glu Asp Ile Ser Glu Ala Cys Leu Ile Leu Gly Val Lys Arg Pro Pro 
                85                  90                  95      


Glu Glu Lys Leu Met Ser Arg Lys Thr Tyr Ala Phe Phe Ser His Thr 
            100                 105                 110         


Ile Lys Ala Gln Glu Ala Asn Met Gly Leu Leu Asp Glu Ile Leu Lys 
        115                 120                 125             


Gln Glu Ile Arg Leu Ile Asp Tyr Glu Lys Met Val Asp His Arg Gly 
    130                 135                 140                 


Val Arg Val Val Ala Phe Gly Gln Trp Ala Gly Val Ala Gly Met Ile 
145                 150                 155                 160 


Asn Ile Leu His Gly Met Gly Leu Arg Leu Leu Ala Leu Gly His His 
                165                 170                 175     


Thr Pro Phe Met His Ile Gly Met Ala His Asn Tyr Arg Asn Ser Ser 
            180                 185                 190         


Gln Ala Val Gln Ala Val Arg Asp Ala Gly Tyr Glu Ile Ser Leu Gly 
        195                 200                 205             


Leu Met Pro Lys Ser Ile Gly Pro Leu Thr Phe Val Phe Thr Gly Thr 
    210                 215                 220                 


Gly Asn Val Ser Lys Gly Ala Gln Ala Ile Phe Asn Glu Leu Pro Cys 
225                 230                 235                 240 


Glu Tyr Val Glu Pro His Glu Leu Lys Glu Val Ser Gln Thr Gly Asp 
                245                 250                 255     


Leu Arg Lys Val Tyr Gly Thr Val Leu Ser Arg His His His Leu Val 
            260                 265                 270         


Arg Lys Thr Asp Ala Val Tyr Asp Pro Ala Glu Tyr Asp Lys His Pro 
        275                 280                 285             


Glu Arg Tyr Ile Ser Arg Phe Asn Thr Asp Ile Ala Pro Tyr Thr Thr 
    290                 295                 300                 


Cys Leu Ile Asn Gly Ile Tyr Trp Glu Gln Asn Thr Pro Arg Leu Leu 
305                 310                 315                 320 


Thr Arg Gln Asp Ala Gln Ser Leu Leu Ala Pro Gly Lys Phe Ser Pro 
                325                 330                 335     


Ala Gly Val Glu Gly Cys Pro Ala Leu Pro His Lys Leu Val Ala Ile 
            340                 345                 350         


Cys Asp Ile Ser Ala Asp Thr Gly Gly Ser Ile Glu Phe Met Thr Glu 
        355                 360                 365             


Cys Thr Thr Ile Glu His Pro Phe Cys Met Tyr Asp Ala Asp Gln His 
    370                 375                 380                 


Ile Ile His Asp Ser Val Glu Gly Ser Gly Ile Leu Met Cys Ser Ile 
385                 390                 395                 400 


Asp Asn Leu Pro Ala Gln Leu Pro Ile Glu Ala Thr Glu Cys Phe Gly 
                405                 410                 415     


Asp Met Leu Tyr Pro Tyr Val Glu Glu Met Ile Leu Ser Asp Ala Thr 
            420                 425                 430         


Gln Pro Leu Glu Ser Gln Asn Phe Ser Pro Val Val Arg Asp Ala Val 
        435                 440                 445             


Ile Thr Ser Asn Gly Thr Leu Pro Asp Lys Tyr Lys Tyr Ile Gln Thr 
    450                 455                 460                 


Leu Arg Glu Ser Arg Glu Arg Ala Gln Ser Leu Ser Met Gly Thr Arg 
465                 470                 475                 480 


Arg Lys Val Leu Val Leu Gly Ser Gly Tyr Ile Ser Glu Pro Val Leu 
                485                 490                 495     


Glu Tyr Leu Ser Arg Asp Gly Asn Ile Glu Ile Thr Val Gly Ser Asp 
            500                 505                 510         


Met Lys Asn Gln Ile Glu Gln Leu Gly Lys Lys Tyr Asn Ile Asn Pro 
        515                 520                 525             


Val Ser Met Asp Ile Cys Lys Gln Glu Glu Lys Leu Gly Phe Leu Val 
    530                 535                 540                 


Ala Lys Gln Asp Leu Val Ile Ser Leu Leu Pro Tyr Val Leu His Pro 
545                 550                 555                 560 


Leu Val Ala Lys Ala Cys Ile Thr Asn Lys Val Asn Met Val Thr Ala 
                565                 570                 575     


Ser Tyr Ile Thr Pro Ala Leu Lys Glu Leu Glu Lys Ser Val Glu Asp 
            580                 585                 590         


Ala Gly Ile Thr Ile Ile Gly Glu Leu Gly Leu Asp Pro Gly Leu Asp 
        595                 600                 605             


His Met Leu Ala Met Glu Thr Ile Asp Lys Ala Lys Glu Val Gly Ala 
    610                 615                 620                 


Thr Ile Glu Ser Tyr Ile Ser Tyr Cys Gly Gly Leu Pro Ala Pro Glu 
625                 630                 635                 640 


His Ser Asn Asn Pro Leu Arg Tyr Lys Phe Ser Trp Ser Pro Val Gly 
                645                 650                 655     


Val Leu Met Asn Val Met Gln Ser Ala Thr Tyr Leu Leu Asp Gly Lys 
            660                 665                 670         


Val Val Asn Val Ala Gly Gly Ile Ser Phe Leu Asp Ala Val Thr Ser 
        675                 680                 685             


Met Asp Phe Phe Pro Gly Leu Asn Leu Glu Gly Tyr Pro Asn Arg Asp 
    690                 695                 700                 


Ser Thr Lys Tyr Ala Glu Ile Tyr Gly Ile Ser Ser Ala His Thr Leu 
705                 710                 715                 720 


Leu Arg Gly Thr Leu Arg Tyr Lys Gly Tyr Met Lys Ala Leu Asn Gly 
                725                 730                 735     


Phe Val Lys Leu Gly Leu Ile Asn Arg Glu Ala Leu Pro Ala Phe Arg 
            740                 745                 750         


Pro Glu Ala Asn Pro Leu Thr Trp Lys Gln Leu Leu Cys Asp Leu Val 
        755                 760                 765             


Gly Ile Ser Pro Ser Ser Glu His Asp Val Leu Lys Glu Ala Val Leu 
    770                 775                 780                 


Lys Lys Leu Gly Gly Asp Asn Thr Gln Leu Glu Ala Ala Glu Trp Leu 
785                 790                 795                 800 


Gly Leu Leu Gly Asp Glu Gln Val Pro Gln Ala Glu Ser Ile Leu Asp 
                805                 810                 815     


Ala Leu Ser Lys His Leu Val Met Lys Leu Ser Tyr Gly Pro Glu Glu 
            820                 825                 830         


Lys Asp Met Ile Val Met Arg Asp Ser Phe Gly Ile Arg His Pro Ser 
        835                 840                 845             


Gly His Leu Glu His Lys Thr Ile Asp Leu Val Ala Tyr Gly Asp Ile 
    850                 855                 860                 


Asn Gly Phe Ser Ala Met Ala Lys Thr Val Gly Leu Pro Thr Ala Met 
865                 870                 875                 880 


Ala Ala Lys Met Leu Leu Asp Gly Glu Ile Gly Ala Lys Gly Leu Met 
                885                 890                 895     


Gly Pro Phe Ser Lys Glu Ile Tyr Gly Pro Ile Leu Glu Arg Ile Lys 
            900                 905                 910         


Ala Glu Gly Ile Ile Tyr Thr Thr Gln Ser Thr Ile Lys Pro 
        915                 920                 925     


<210>  30
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AATF__Homo_sapiens__NP_036270

<400>  30

Met Ala Gly Pro Gln Pro Leu Ala Leu Gln Leu Glu Gln Leu Leu Asn 
1               5                   10                  15      


Pro Arg Pro Ser Glu Ala Asp Pro Glu Ala Asp Pro Glu Glu Ala Thr 
            20                  25                  30          


Ala Ala Arg Val Ile Asp Arg Phe Asp Glu Gly Glu Asp Gly Glu Gly 
        35                  40                  45              


Asp Phe Leu Val Val Gly Ser Ile Arg Lys Leu Ala Ser Ala Ser Leu 
    50                  55                  60                  


Leu Asp Thr Asp Lys Arg Tyr Cys Gly Lys Thr Thr Ser Arg Lys Ala 
65                  70                  75                  80  


Trp Asn Glu Asp His Trp Glu Gln Thr Leu Pro Gly Ser Ser Asp Glu 
                85                  90                  95      


Glu Ile Ser Asp Glu Glu Gly Ser Gly Asp Glu Asp Ser Glu Gly Leu 
            100                 105                 110         


Gly Leu Glu Glu Tyr Asp Glu Asp Asp Leu Gly Ala Ala Glu Glu Gln 
        115                 120                 125             


Glu Cys Gly Asp His Arg Glu Ser Lys Lys Ser Arg Ser His Ser Ala 
    130                 135                 140                 


Lys Thr Pro Gly Phe Ser Val Gln Ser Ile Ser Asp Phe Glu Lys Phe 
145                 150                 155                 160 


Thr Lys Gly Met Asp Asp Leu Gly Ser Ser Glu Glu Glu Glu Asp Glu 
                165                 170                 175     


Glu Ser Gly Met Glu Glu Gly Asp Asp Ala Glu Asp Ser Gln Gly Glu 
            180                 185                 190         


Ser Glu Glu Asp Arg Ala Gly Asp Arg Asn Ser Glu Asp Asp Gly Val 
        195                 200                 205             


Val Met Thr Phe Ser Ser Val Lys Val Ser Glu Glu Val Glu Lys Gly 
    210                 215                 220                 


Arg Ala Val Lys Asn Gln Ile Ala Leu Trp Asp Gln Leu Leu Glu Gly 
225                 230                 235                 240 


Arg Ile Lys Leu Gln Lys Ala Leu Leu Thr Thr Asn Gln Leu Pro Gln 
                245                 250                 255     


Pro Asp Val Phe Pro Leu Phe Lys Asp Lys Gly Gly Pro Glu Phe Ser 
            260                 265                 270         


Ser Ala Leu Lys Asn Ser His Lys Ala Leu Lys Ala Leu Leu Arg Ser 
        275                 280                 285             


Leu Val Gly Leu Gln Glu Glu Leu Leu Phe Gln Tyr Pro Asp Thr Arg 
    290                 295                 300                 


Tyr Leu Val Asp Gly Thr Lys Pro Asn Ala Gly Ser Glu Glu Ile Ser 
305                 310                 315                 320 


Ser Glu Asp Asp Glu Leu Val Glu Glu Lys Lys Gln Gln Arg Arg Arg 
                325                 330                 335     


Val Pro Ala Lys Arg Lys Leu Glu Met Glu Asp Tyr Pro Ser Phe Met 
            340                 345                 350         


Ala Lys Arg Phe Ala Asp Phe Thr Val Tyr Arg Asn Arg Thr Leu Gln 
        355                 360                 365             


Lys Trp His Asp Lys Thr Lys Leu Ala Ser Gly Lys Leu Gly Lys Gly 
    370                 375                 380                 


Phe Gly Ala Phe Glu Arg Ser Ile Leu Thr Gln Ile Asp His Ile Leu 
385                 390                 395                 400 


Met Asp Lys Glu Arg Leu Leu Arg Arg Thr Gln Thr Lys Arg Ser Val 
                405                 410                 415     


Tyr Arg Val Leu Gly Lys Pro Glu Pro Ala Ala Gln Pro Val Pro Glu 
            420                 425                 430         


Ser Leu Pro Gly Glu Pro Glu Ile Leu Pro Gln Ala Pro Ala Asn Ala 
        435                 440                 445             


His Leu Lys Asp Leu Asp Glu Glu Ile Phe Asp Asp Asp Asp Phe Tyr 
    450                 455                 460                 


His Gln Leu Leu Arg Glu Leu Ile Glu Arg Lys Thr Ser Ser Leu Asp 
465                 470                 475                 480 


Pro Asn Asp Gln Val Ala Met Gly Arg Gln Trp Leu Ala Ile Gln Lys 
                485                 490                 495     


Leu Arg Ser Lys Ile His Lys Lys Val Asp Arg Lys Ala Ser Lys Gly 
            500                 505                 510         


Arg Lys Leu Arg Phe His Val Leu Ser Lys Leu Leu Ser Phe Met Ala 
        515                 520                 525             


Pro Ile Asp His Thr Thr Met Asn Asp Asp Ala Arg Thr Glu Leu Tyr 
    530                 535                 540                 


Arg Ser Leu Phe Gly Gln Leu His Pro Pro Asp Glu Gly His Gly Asp 
545                 550                 555                 560 


<210>  31
<211>  1374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AATK__Homo_sapiens__NP_001073864

<400>  31

Met Ser Ser Ser Phe Phe Asn Pro Ser Phe Ala Phe Ser Ser His Phe 
1               5                   10                  15      


Asp Pro Asp Gly Ala Pro Leu Ser Glu Leu Ser Trp Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Val Ala Val Ser Phe Ser Gly Leu Phe Ala Val Ile Val Leu 
        35                  40                  45              


Met Leu Ala Cys Leu Cys Cys Lys Lys Gly Gly Ile Gly Phe Lys Glu 
    50                  55                  60                  


Phe Glu Asn Ala Glu Gly Asp Glu Tyr Ala Ala Asp Leu Ala Gln Gly 
65                  70                  75                  80  


Ser Pro Ala Thr Ala Ala Gln Asn Gly Pro Asp Val Tyr Val Leu Pro 
                85                  90                  95      


Leu Thr Glu Val Ser Leu Pro Met Ala Lys Gln Pro Gly Arg Ser Val 
            100                 105                 110         


Gln Leu Leu Lys Ser Thr Asp Val Gly Arg His Ser Leu Leu Tyr Leu 
        115                 120                 125             


Lys Glu Ile Gly Arg Gly Trp Phe Gly Lys Val Phe Leu Gly Glu Val 
    130                 135                 140                 


Asn Ser Gly Ile Ser Ser Ala Gln Val Val Val Lys Glu Leu Gln Ala 
145                 150                 155                 160 


Ser Ala Ser Val Gln Glu Gln Met Gln Phe Leu Glu Glu Val Gln Pro 
                165                 170                 175     


Tyr Arg Ala Leu Lys His Ser Asn Leu Leu Gln Cys Leu Ala Gln Cys 
            180                 185                 190         


Ala Glu Val Thr Pro Tyr Leu Leu Val Met Glu Phe Cys Pro Leu Gly 
        195                 200                 205             


Asp Leu Lys Gly Tyr Leu Arg Ser Cys Arg Val Ala Glu Ser Met Ala 
    210                 215                 220                 


Pro Asp Pro Arg Thr Leu Gln Arg Met Ala Cys Glu Val Ala Cys Gly 
225                 230                 235                 240 


Val Leu His Leu His Arg Asn Asn Phe Val His Ser Asp Leu Ala Leu 
                245                 250                 255     


Arg Asn Cys Leu Leu Thr Ala Asp Leu Thr Val Lys Ile Gly Asp Tyr 
            260                 265                 270         


Gly Leu Ala His Cys Lys Tyr Arg Glu Asp Tyr Phe Val Thr Ala Asp 
        275                 280                 285             


Gln Leu Trp Val Pro Leu Arg Trp Ile Ala Pro Glu Leu Val Asp Glu 
    290                 295                 300                 


Val His Ser Asn Leu Leu Val Val Asp Gln Thr Lys Ser Gly Asn Val 
305                 310                 315                 320 


Trp Ser Leu Gly Val Thr Ile Trp Glu Leu Phe Glu Leu Gly Thr Gln 
                325                 330                 335     


Pro Tyr Pro Gln His Ser Asp Gln Gln Val Leu Ala Tyr Thr Val Arg 
            340                 345                 350         


Glu Gln Gln Leu Lys Leu Pro Lys Pro Gln Leu Gln Leu Thr Leu Ser 
        355                 360                 365             


Asp Arg Trp Tyr Glu Val Met Gln Phe Cys Trp Leu Gln Pro Glu Gln 
    370                 375                 380                 


Arg Pro Thr Ala Glu Glu Val His Leu Leu Leu Ser Tyr Leu Cys Ala 
385                 390                 395                 400 


Lys Gly Ala Thr Glu Ala Glu Glu Glu Phe Glu Arg Arg Trp Arg Ser 
                405                 410                 415     


Leu Arg Pro Gly Gly Gly Gly Val Gly Pro Gly Pro Gly Ala Ala Gly 
            420                 425                 430         


Pro Met Leu Gly Gly Val Val Glu Leu Ala Ala Ala Ser Ser Phe Pro 
        435                 440                 445             


Leu Leu Glu Gln Phe Ala Gly Asp Gly Phe His Ala Asp Gly Asp Asp 
    450                 455                 460                 


Val Leu Thr Val Thr Glu Thr Ser Arg Gly Leu Asn Phe Glu Tyr Lys 
465                 470                 475                 480 


Trp Glu Ala Gly Arg Gly Ala Glu Ala Phe Pro Ala Thr Leu Ser Pro 
                485                 490                 495     


Gly Arg Thr Ala Arg Leu Gln Glu Leu Cys Ala Pro Asp Gly Ala Pro 
            500                 505                 510         


Pro Gly Val Val Pro Val Leu Ser Ala His Ser Pro Ser Leu Gly Ser 
        515                 520                 525             


Glu Tyr Phe Ile Arg Leu Glu Glu Ala Ala Pro Ala Ala Gly His Asp 
    530                 535                 540                 


Pro Asp Cys Ala Gly Cys Ala Pro Ser Pro Pro Ala Thr Ala Asp Gln 
545                 550                 555                 560 


Asp Asp Asp Ser Asp Gly Ser Thr Ala Ala Ser Leu Ala Met Glu Pro 
                565                 570                 575     


Leu Leu Gly His Gly Pro Pro Val Asp Val Pro Trp Gly Arg Gly Asp 
            580                 585                 590         


His Tyr Pro Arg Arg Ser Leu Ala Arg Asp Pro Leu Cys Pro Ser Arg 
        595                 600                 605             


Ser Pro Ser Pro Ser Ala Gly Pro Leu Ser Leu Ala Glu Gly Gly Ala 
    610                 615                 620                 


Glu Asp Ala Asp Trp Gly Val Ala Ala Phe Cys Pro Ala Phe Phe Glu 
625                 630                 635                 640 


Asp Pro Leu Gly Thr Ser Pro Leu Gly Ser Ser Gly Ala Pro Pro Leu 
                645                 650                 655     


Pro Leu Thr Gly Glu Asp Glu Leu Glu Glu Val Gly Ala Arg Arg Ala 
            660                 665                 670         


Ala Gln Arg Gly His Trp Arg Ser Asn Val Ser Ala Asn Asn Asn Ser 
        675                 680                 685             


Gly Ser Arg Cys Pro Glu Ser Trp Asp Pro Val Ser Ala Gly Gly His 
    690                 695                 700                 


Ala Glu Gly Cys Pro Ser Pro Lys Gln Thr Pro Arg Ala Ser Pro Glu 
705                 710                 715                 720 


Pro Gly Tyr Pro Gly Glu Pro Leu Leu Gly Leu Gln Ala Ala Ser Ala 
                725                 730                 735     


Gln Glu Pro Gly Cys Cys Pro Gly Leu Pro His Leu Cys Ser Ala Gln 
            740                 745                 750         


Gly Leu Ala Pro Ala Pro Cys Leu Val Thr Pro Ser Trp Thr Glu Thr 
        755                 760                 765             


Ala Ser Ser Gly Gly Asp His Pro Gln Ala Glu Pro Lys Leu Ala Thr 
    770                 775                 780                 


Glu Ala Glu Gly Thr Thr Gly Pro Arg Leu Pro Leu Pro Ser Val Pro 
785                 790                 795                 800 


Ser Pro Ser Gln Glu Gly Ala Pro Leu Pro Ser Glu Glu Ala Ser Ala 
                805                 810                 815     


Pro Asp Ala Pro Asp Ala Leu Pro Asp Ser Pro Thr Pro Ala Thr Gly 
            820                 825                 830         


Gly Glu Val Ser Ala Ile Lys Leu Ala Ser Ala Leu Asn Gly Ser Ser 
        835                 840                 845             


Ser Ser Pro Glu Val Glu Ala Pro Ser Ser Glu Asp Glu Asp Thr Ala 
    850                 855                 860                 


Glu Ala Thr Ser Gly Ile Phe Thr Asp Thr Ser Ser Asp Gly Leu Gln 
865                 870                 875                 880 


Ala Arg Arg Pro Asp Val Val Pro Ala Phe Arg Ser Leu Gln Lys Gln 
                885                 890                 895     


Val Gly Thr Pro Asp Ser Leu Asp Ser Leu Asp Ile Pro Ser Ser Ala 
            900                 905                 910         


Ser Asp Gly Gly Tyr Glu Val Phe Ser Pro Ser Ala Thr Gly Pro Ser 
        915                 920                 925             


Gly Gly Gln Pro Arg Ala Leu Asp Ser Gly Tyr Asp Thr Glu Asn Tyr 
    930                 935                 940                 


Glu Ser Pro Glu Phe Val Leu Lys Glu Ala Gln Glu Gly Cys Glu Pro 
945                 950                 955                 960 


Gln Ala Phe Ala Glu Leu Ala Ser Glu Gly Glu Gly Pro Gly Pro Glu 
                965                 970                 975     


Thr Arg Leu Ser Thr Ser Leu Ser Gly Leu Asn Glu Lys Asn Pro Tyr 
            980                 985                 990         


Arg Asp Ser Ala Tyr Phe Ser Asp  Leu Glu Ala Glu Ala  Glu Ala Thr 
        995                 1000                 1005             


Ser Gly  Pro Glu Lys Lys Cys  Gly Gly Asp Arg Ala  Pro Gly Pro 
    1010                 1015                 1020             


Glu Leu  Gly Leu Pro Ser Thr  Gly Gln Pro Ser Glu  Gln Val Cys 
    1025                 1030                 1035             


Leu Arg  Pro Gly Val Ser Gly  Glu Ala Gln Gly Ser  Gly Pro Gly 
    1040                 1045                 1050             


Glu Val  Leu Pro Pro Leu Leu  Gln Leu Glu Gly Ser  Ser Pro Glu 
    1055                 1060                 1065             


Pro Ser  Thr Cys Pro Ser Gly  Leu Val Pro Glu Pro  Pro Glu Pro 
    1070                 1075                 1080             


Gln Gly  Pro Ala Lys Val Arg  Pro Gly Pro Ser Pro  Ser Cys Ser 
    1085                 1090                 1095             


Gln Phe  Phe Leu Leu Thr Pro  Val Pro Leu Arg Ser  Glu Gly Asn 
    1100                 1105                 1110             


Ser Ser  Glu Phe Gln Gly Pro  Pro Gly Leu Leu Ser  Gly Pro Ala 
    1115                 1120                 1125             


Pro Gln  Lys Arg Met Gly Gly  Pro Gly Thr Pro Arg  Ala Pro Leu 
    1130                 1135                 1140             


Arg Leu  Ala Leu Pro Gly Leu  Pro Ala Ala Leu Glu  Gly Arg Pro 
    1145                 1150                 1155             


Glu Glu  Glu Glu Glu Asp Ser  Glu Asp Ser Asp Glu  Ser Asp Glu 
    1160                 1165                 1170             


Glu Leu  Arg Cys Tyr Ser Val  Gln Glu Pro Ser Glu  Asp Ser Glu 
    1175                 1180                 1185             


Glu Glu  Ala Pro Ala Val Pro  Val Val Val Ala Glu  Ser Gln Ser 
    1190                 1195                 1200             


Ala Arg  Asn Leu Arg Ser Leu  Leu Lys Met Pro Ser  Leu Leu Ser 
    1205                 1210                 1215             


Glu Thr  Phe Cys Glu Asp Leu  Glu Arg Lys Lys Lys  Ala Val Ser 
    1220                 1225                 1230             


Phe Phe  Asp Asp Val Thr Val  Tyr Leu Phe Asp Gln  Glu Ser Pro 
    1235                 1240                 1245             


Thr Arg  Glu Leu Gly Glu Pro  Phe Pro Gly Ala Lys  Glu Ser Pro 
    1250                 1255                 1260             


Pro Thr  Phe Leu Arg Gly Ser  Pro Gly Ser Pro Ser  Ala Pro Asn 
    1265                 1270                 1275             


Arg Pro  Gln Gln Ala Asp Gly  Ser Pro Asn Gly Ser  Thr Ala Glu 
    1280                 1285                 1290             


Glu Gly  Gly Gly Phe Ala Trp  Asp Asp Asp Phe Pro  Leu Met Thr 
    1295                 1300                 1305             


Ala Lys  Ala Ala Phe Ala Met  Ala Leu Asp Pro Ala  Ala Pro Ala 
    1310                 1315                 1320             


Pro Ala  Ala Pro Thr Pro Thr  Pro Ala Pro Phe Ser  Arg Phe Thr 
    1325                 1330                 1335             


Val Ser  Pro Ala Pro Thr Ser  Arg Phe Ser Ile Thr  His Val Ser 
    1340                 1345                 1350             


Asp Ser  Asp Ala Glu Ser Lys  Arg Gly Pro Glu Ala  Gly Ala Gly 
    1355                 1360                 1365             


Gly Glu  Ser Lys Glu Ala 
    1370                 


<210>  32
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABAT__Homo_sapiens__XP_011520703

<400>  32

Met Ala Ser Met Leu Leu Ala Gln Arg Leu Ala Cys Ser Phe Gln His 
1               5                   10                  15      


Ser Tyr Arg Leu Leu Val Pro Gly Ser Arg His Ile Ser Gln Ala Ala 
            20                  25                  30          


Ala Lys Val Asp Val Glu Phe Asp Tyr Asp Gly Pro Leu Met Lys Thr 
        35                  40                  45              


Glu Val Pro Gly Pro Arg Ser Gln Glu Leu Met Lys Gln Leu Asn Ile 
    50                  55                  60                  


Ile Gln Asn Ala Glu Ala Val His Phe Phe Cys Asn Tyr Glu Glu Ser 
65                  70                  75                  80  


Arg Gly Asn Tyr Leu Val Asp Val Asp Gly Asn Arg Met Leu Asp Leu 
                85                  90                  95      


Tyr Ser Gln Ile Ser Ser Val Pro Ile Gly Tyr Ser His Pro Ala Leu 
            100                 105                 110         


Leu Lys Leu Ile Gln Gln Pro Gln Asn Ala Ser Met Phe Val Asn Arg 
        115                 120                 125             


Pro Ala Leu Gly Ile Leu Pro Pro Glu Asn Phe Val Glu Lys Leu Arg 
    130                 135                 140                 


Gln Ser Leu Leu Ser Val Ala Pro Lys Gly Met Ser Gln Leu Ile Thr 
145                 150                 155                 160 


Met Ala Cys Gly Ser Cys Ser Asn Glu Asn Ala Leu Lys Thr Ile Phe 
                165                 170                 175     


Met Trp Tyr Arg Ser Lys Glu Arg Gly Gln Arg Gly Phe Ser Gln Glu 
            180                 185                 190         


Glu Leu Glu Thr Cys Met Ile Asn Gln Ala Pro Gly Cys Pro Asp Tyr 
        195                 200                 205             


Ser Ile Leu Ser Phe Met Gly Ala Phe His Gly Arg Thr Met Gly Cys 
    210                 215                 220                 


Leu Ala Thr Thr His Ser Lys Ala Ile His Lys Ile Asp Ile Pro Ser 
225                 230                 235                 240 


Phe Asp Trp Pro Ile Ala Pro Phe Pro Arg Leu Lys Tyr Pro Leu Glu 
                245                 250                 255     


Glu Phe Val Lys Glu Asn Gln Gln Glu Glu Ala Arg Cys Leu Glu Glu 
            260                 265                 270         


Val Glu Asp Leu Ile Val Lys Tyr Arg Lys Lys Lys Lys Thr Val Ala 
        275                 280                 285             


Gly Ile Ile Val Glu Pro Ile Gln Ser Glu Gly Gly Asp Asn His Ala 
    290                 295                 300                 


Ser Asp Asp Phe Phe Arg Lys Leu Arg Asp Ile Ala Arg Lys His Gly 
305                 310                 315                 320 


Cys Ala Phe Leu Val Asp Glu Val Gln Thr Gly Gly Gly Cys Thr Gly 
                325                 330                 335     


Lys Phe Trp Ala His Glu His Trp Gly Leu Asp Asp Pro Ala Asp Val 
            340                 345                 350         


Met Thr Phe Ser Lys Lys Met Met Thr Gly Gly Phe Phe His Lys Glu 
        355                 360                 365             


Glu Phe Arg Pro Asn Ala Pro Tyr Arg Ile Phe Asn Thr Trp Leu Gly 
    370                 375                 380                 


Asp Pro Ser Lys Asn Leu Leu Leu Ala Glu Val Ile Asn Ile Ile Lys 
385                 390                 395                 400 


Arg Glu Asp Leu Leu Asn Asn Ala Ala His Ala Gly Lys Ala Leu Leu 
                405                 410                 415     


Thr Gly Leu Leu Asp Leu Gln Ala Arg Tyr Pro Gln Phe Ile Ser Arg 
            420                 425                 430         


Val Arg Gly Arg Gly Thr Phe Cys Ser Phe Asp Thr Pro Asp Asp Ser 
        435                 440                 445             


Ile Arg Asn Lys Leu Ile Leu Ile Ala Arg Asn Lys Gly Val Val Leu 
    450                 455                 460                 


Gly Gly Cys Gly Asp Lys Ser Ile Arg Phe Arg Pro Thr Leu Val Phe 
465                 470                 475                 480 


Arg Asp His His Ala His Leu Phe Leu Asn Ile Phe Ser Asp Ile Leu 
                485                 490                 495     


Ala Asp Phe Lys 
            500 


<210>  33
<211>  2277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA12__Homo_sapiens__NP_056472

<400>  33

Met Phe Thr Tyr Ile Lys Ile Ile Thr Ser Gly Asp Ser Asp Asn Ile 
1               5                   10                  15      


Thr His Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser 
            20                  25                  30          


Leu Ala Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu 
        35                  40                  45              


Asn Ile Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg 
    50                  55                  60                  


Asn Val Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu 
65                  70                  75                  80  


Leu Gln Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser 
                85                  90                  95      


Tyr Glu Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu 
            100                 105                 110         


Ser Gln Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe 
        115                 120                 125             


Ser Leu Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser 
    130                 135                 140                 


Leu Cys Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu 
145                 150                 155                 160 


Leu Gly Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile 
                165                 170                 175     


Ser Lys Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn 
            180                 185                 190         


Leu Asn Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu 
        195                 200                 205             


Glu Asn Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val 
    210                 215                 220                 


Asn Asn Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met 
225                 230                 235                 240 


Phe Lys Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly 
                245                 250                 255     


Met Ser Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp 
            260                 265                 270         


Asn Arg Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp 
        275                 280                 285             


Thr Asn Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys 
    290                 295                 300                 


Asn Leu Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu 
305                 310                 315                 320 


Thr Leu Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Val Phe 
                325                 330                 335     


Phe Pro Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe 
            340                 345                 350         


Ile Arg Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro 
        355                 360                 365             


Leu Leu Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser 
    370                 375                 380                 


Val Pro Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro 
385                 390                 395                 400 


Gln Gly Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile 
                405                 410                 415     


Thr Thr Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys 
            420                 425                 430         


Gly Asn His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln 
        435                 440                 445             


Ile Ala Ser Lys Tyr Gly Ile Pro Ile Asn Ser Thr Pro Phe Cys Phe 
    450                 455                 460                 


Ser Leu Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp 
465                 470                 475                 480 


Ala Phe Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr 
                485                 490                 495     


Asn Pro Val Thr Lys Ala Ile Met Glu Lys Ser Asn Val Thr Leu Arg 
            500                 505                 510         


Gln Leu Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser 
        515                 520                 525             


Pro Leu Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met 
    530                 535                 540                 


Leu Gln Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe 
545                 550                 555                 560 


Ser Val Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu 
                565                 570                 575     


Asp Ile Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln 
            580                 585                 590         


Leu Asn Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu 
        595                 600                 605             


Tyr Asp Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu 
    610                 615                 620                 


Ala Lys Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe 
625                 630                 635                 640 


Lys Leu Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn 
                645                 650                 655     


Val Phe Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys 
            660                 665                 670         


Thr Ala Gln Thr Thr Arg Ser Leu Arg Thr Lys Ile Trp Ala Pro Gly 
        675                 680                 685             


Pro His Asn Ser Pro Ser His Asn Gln Ile Tyr Gly Arg Ala Phe Ile 
    690                 695                 700                 


Tyr Leu Gln Asp Ser Ile Glu Arg Ala Ile Ile Glu Leu Gln Thr Gly 
705                 710                 715                 720 


Arg Asn Ser Gln Glu Ile Ala Val Gln Val Gln Ala Ile Pro Tyr Pro 
                725                 730                 735     


Cys Phe Met Lys Asp Asn Phe Leu Thr Ser Val Ser Tyr Ser Leu Pro 
            740                 745                 750         


Ile Val Leu Met Val Ala Trp Val Val Phe Ile Ala Ala Phe Val Lys 
        755                 760                 765             


Lys Leu Val Tyr Glu Lys Asp Leu Arg Leu His Glu Tyr Met Lys Met 
    770                 775                 780                 


Met Gly Val Asn Ser Cys Ser His Phe Phe Ala Trp Leu Ile Glu Ser 
785                 790                 795                 800 


Val Gly Phe Leu Leu Val Thr Ile Val Ile Leu Ile Ile Ile Leu Lys 
                805                 810                 815     


Phe Gly Asn Ile Leu Pro Lys Thr Asn Gly Phe Ile Leu Phe Leu Tyr 
            820                 825                 830         


Phe Ser Asp Tyr Ser Phe Ser Val Ile Ala Met Ser Tyr Leu Ile Ser 
        835                 840                 845             


Val Phe Phe Asn Asn Thr Asn Ile Ala Ala Leu Ile Gly Ser Leu Ile 
    850                 855                 860                 


Tyr Ile Ile Ala Phe Phe Pro Phe Ile Val Leu Val Thr Val Glu Asn 
865                 870                 875                 880 


Glu Leu Ser Tyr Val Leu Lys Val Phe Met Ser Leu Leu Ser Pro Thr 
                885                 890                 895     


Ala Phe Ser Tyr Ala Ser Gln Tyr Ile Ala Arg Tyr Glu Glu Gln Gly 
            900                 905                 910         


Ile Gly Leu Gln Trp Glu Asn Met Tyr Thr Ser Pro Val Gln Asp Asp 
        915                 920                 925             


Thr Thr Ser Phe Gly Trp Leu Cys Cys Leu Ile Leu Ala Asp Ser Phe 
    930                 935                 940                 


Ile Tyr Phe Leu Ile Ala Trp Tyr Val Arg Asn Val Phe Pro Gly Thr 
945                 950                 955                 960 


Tyr Gly Met Ala Ala Pro Trp Tyr Phe Pro Ile Leu Pro Ser Tyr Trp 
                965                 970                 975     


Lys Glu Arg Phe Gly Cys Ala Glu Val Lys Pro Glu Lys Ser Asn Gly 
            980                 985                 990         


Leu Met Phe Thr Asn Ile Met Met  Gln Asn Thr Asn Pro  Ser Ala Ser 
        995                 1000                 1005             


Pro Glu  Tyr Met Phe Ser Ser  Asn Ile Glu Pro Glu  Pro Lys Asp 
    1010                 1015                 1020             


Leu Thr  Val Gly Val Ala Leu  His Gly Val Thr Lys  Ile Tyr Gly 
    1025                 1030                 1035             


Ser Lys  Val Ala Val Asp Asn  Leu Asn Leu Asn Phe  Tyr Glu Gly 
    1040                 1045                 1050             


His Ile  Thr Ser Leu Leu Gly  Pro Asn Gly Ala Gly  Lys Thr Thr 
    1055                 1060                 1065             


Thr Ile  Ser Met Leu Thr Gly  Leu Phe Gly Ala Ser  Ala Gly Thr 
    1070                 1075                 1080             


Ile Phe  Val Tyr Gly Lys Asp  Ile Lys Thr Asp Leu  His Thr Val 
    1085                 1090                 1095             


Arg Lys  Asn Met Gly Val Cys  Met Gln His Asp Val  Leu Phe Ser 
    1100                 1105                 1110             


Tyr Leu  Thr Thr Lys Glu His  Leu Leu Leu Tyr Gly  Ser Ile Lys 
    1115                 1120                 1125             


Val Pro  His Trp Thr Lys Lys  Gln Leu His Glu Glu  Val Lys Arg 
    1130                 1135                 1140             


Thr Leu  Lys Asp Thr Gly Leu  Tyr Ser His Arg His  Lys Arg Val 
    1145                 1150                 1155             


Gly Thr  Leu Ser Gly Gly Met  Lys Arg Lys Leu Ser  Ile Ser Ile 
    1160                 1165                 1170             


Ala Leu  Ile Gly Gly Ser Arg  Val Val Ile Leu Asp  Glu Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Asp Pro Cys Ser  Arg Arg Ser Ile Trp  Asp Val Ile 
    1190                 1195                 1200             


Ser Lys  Asn Lys Thr Ala Arg  Thr Ile Ile Leu Ser  Thr His His 
    1205                 1210                 1215             


Leu Asp  Glu Ala Glu Val Leu  Ser Asp Arg Ile Ala  Phe Leu Glu 
    1220                 1225                 1230             


Gln Gly  Gly Leu Arg Cys Cys  Gly Ser Pro Phe Tyr  Leu Lys Glu 
    1235                 1240                 1245             


Ala Phe  Gly Asp Gly Tyr His  Leu Thr Leu Thr Lys  Lys Lys Ser 
    1250                 1255                 1260             


Pro Asn  Leu Asn Ala Asn Ala  Val Cys Asp Thr Met  Ala Val Thr 
    1265                 1270                 1275             


Ala Met  Ile Gln Ser His Leu  Pro Glu Ala Tyr Leu  Lys Glu Asp 
    1280                 1285                 1290             


Ile Gly  Gly Glu Leu Val Tyr  Val Leu Pro Pro Phe  Ser Thr Lys 
    1295                 1300                 1305             


Val Ser  Gly Ala Tyr Leu Ser  Leu Leu Arg Ala Leu  Asp Asn Gly 
    1310                 1315                 1320             


Met Gly  Asp Leu Asn Ile Gly  Cys Tyr Gly Ile Ser  Asp Thr Thr 
    1325                 1330                 1335             


Val Glu  Glu Val Phe Leu Asn  Leu Thr Lys Glu Ser  Gln Lys Asn 
    1340                 1345                 1350             


Ser Ala  Met Ser Leu Glu His  Leu Thr Gln Lys Lys  Ile Gly Asn 
    1355                 1360                 1365             


Ser Asn  Ala Asn Gly Ile Ser  Thr Pro Asp Asp Leu  Ser Val Ser 
    1370                 1375                 1380             


Ser Ser  Asn Phe Thr Asp Arg  Asp Asp Lys Ile Leu  Thr Arg Gly 
    1385                 1390                 1395             


Glu Arg  Leu Asp Gly Phe Gly  Leu Leu Leu Lys Lys  Ile Met Ala 
    1400                 1405                 1410             


Ile Leu  Ile Lys Arg Phe His  His Thr Arg Arg Asn  Trp Lys Gly 
    1415                 1420                 1425             


Leu Ile  Ala Gln Val Ile Leu  Pro Ile Val Phe Val  Thr Thr Ala 
    1430                 1435                 1440             


Met Gly  Leu Gly Thr Leu Arg  Asn Ser Ser Asn Ser  Tyr Pro Glu 
    1445                 1450                 1455             


Ile Gln  Ile Ser Pro Ser Leu  Tyr Gly Thr Ser Glu  Gln Thr Ala 
    1460                 1465                 1470             


Phe Tyr  Ala Asn Tyr His Pro  Ser Thr Glu Ala Leu  Val Ser Ala 
    1475                 1480                 1485             


Met Trp  Asp Phe Pro Gly Ile  Asp Asn Met Cys Leu  Asn Thr Ser 
    1490                 1495                 1500             


Asp Leu  Gln Cys Leu Asn Lys  Asp Ser Leu Glu Lys  Trp Asn Thr 
    1505                 1510                 1515             


Ser Gly  Glu Pro Ile Thr Asn  Phe Gly Val Cys Ser  Cys Ser Glu 
    1520                 1525                 1530             


Asn Val  Gln Glu Cys Pro Lys  Phe Asn Tyr Ser Pro  Pro His Arg 
    1535                 1540                 1545             


Arg Thr  Tyr Ser Ser Gln Val  Ile Tyr Asn Leu Thr  Gly Gln Arg 
    1550                 1555                 1560             


Val Glu  Asn Tyr Leu Ile Ser  Thr Ala Asn Glu Phe  Val Gln Lys 
    1565                 1570                 1575             


Arg Tyr  Gly Gly Trp Ser Phe  Gly Leu Pro Leu Thr  Lys Asp Leu 
    1580                 1585                 1590             


Arg Phe  Asp Ile Thr Gly Val  Pro Ala Asn Arg Thr  Leu Ala Lys 
    1595                 1600                 1605             


Val Trp  Tyr Asp Pro Glu Gly  Tyr His Ser Leu Pro  Ala Tyr Leu 
    1610                 1615                 1620             


Asn Ser  Leu Asn Asn Phe Leu  Leu Arg Val Asn Met  Ser Lys Tyr 
    1625                 1630                 1635             


Asp Ala  Ala Arg His Gly Ile  Ile Met Tyr Ser His  Pro Tyr Pro 
    1640                 1645                 1650             


Gly Val  Gln Asp Gln Glu Gln  Ala Thr Ile Ser Ser  Leu Ile Asp 
    1655                 1660                 1665             


Ile Leu  Val Ala Leu Ser Ile  Leu Met Gly Tyr Ser  Val Thr Thr 
    1670                 1675                 1680             


Ala Ser  Phe Val Thr Tyr Val  Val Arg Glu His Gln  Thr Lys Ala 
    1685                 1690                 1695             


Lys Gln  Leu Gln His Ile Ser  Gly Ile Gly Val Thr  Cys Tyr Trp 
    1700                 1705                 1710             


Val Thr  Asn Phe Ile Tyr Asp  Met Val Phe Tyr Leu  Val Pro Val 
    1715                 1720                 1725             


Ala Phe  Ser Ile Gly Ile Ile  Ala Ile Phe Lys Leu  Pro Ala Phe 
    1730                 1735                 1740             


Tyr Ser  Glu Asn Asn Leu Gly  Ala Val Ser Leu Leu  Leu Leu Leu 
    1745                 1750                 1755             


Phe Gly  Tyr Ala Thr Phe Ser  Trp Met Tyr Leu Leu  Ala Gly Leu 
    1760                 1765                 1770             


Phe His  Glu Thr Gly Met Ala  Phe Ile Thr Tyr Val  Cys Val Asn 
    1775                 1780                 1785             


Leu Phe  Phe Gly Ile Asn Ser  Ile Val Ser Leu Ser  Val Val Tyr 
    1790                 1795                 1800             


Phe Leu  Ser Lys Glu Lys Pro  Asn Asp Pro Thr Leu  Glu Leu Ile 
    1805                 1810                 1815             


Ser Glu  Thr Leu Lys Arg Ile  Phe Leu Ile Phe Pro  Gln Phe Cys 
    1820                 1825                 1830             


Phe Gly  Tyr Gly Leu Ile Glu  Leu Ser Gln Gln Gln  Ser Val Leu 
    1835                 1840                 1845             


Asp Phe  Leu Lys Ala Tyr Gly  Val Glu Tyr Pro Asn  Glu Thr Phe 
    1850                 1855                 1860             


Glu Met  Asn Lys Leu Gly Ala  Met Phe Val Ala Leu  Val Ser Gln 
    1865                 1870                 1875             


Gly Thr  Met Phe Phe Ser Leu  Arg Leu Leu Ile Asn  Glu Ser Leu 
    1880                 1885                 1890             


Ile Lys  Lys Leu Arg Leu Phe  Phe Arg Lys Phe Asn  Ser Ser His 
    1895                 1900                 1905             


Val Arg  Glu Thr Ile Asp Glu  Asp Glu Asp Val Arg  Ala Glu Arg 
    1910                 1915                 1920             


Leu Arg  Val Glu Ser Gly Ala  Ala Glu Phe Asp Leu  Val Gln Leu 
    1925                 1930                 1935             


Tyr Cys  Leu Thr Lys Thr Tyr  Gln Leu Ile His Lys  Lys Ile Ile 
    1940                 1945                 1950             


Ala Val  Asn Asn Ile Ser Ile  Gly Ile Pro Ala Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Ile Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Ile Ile  Pro Ser Ser Gly Asn  Ile Leu Ile 
    1985                 1990                 1995             


Arg Asn  Lys Thr Gly Ser Leu  Gly His Val Asp Ser  His Ser Ser 
    2000                 2005                 2010             


Leu Val  Gly Tyr Cys Pro Gln  Glu Asp Ala Leu Asp  Asp Leu Val 
    2015                 2020                 2025             


Thr Val  Glu Glu His Leu Tyr  Phe Tyr Ala Arg Val  His Gly Ile 
    2030                 2035                 2040             


Pro Glu  Lys Asp Ile Lys Glu  Thr Val His Lys Leu  Leu Arg Arg 
    2045                 2050                 2055             


Leu His  Leu Met Pro Phe Lys  Asp Arg Ala Thr Ser  Met Cys Ser 
    2060                 2065                 2070             


Tyr Gly  Thr Lys Arg Lys Leu  Ser Thr Ala Leu Ala  Leu Ile Gly 
    2075                 2080                 2085             


Lys Pro  Ser Ile Leu Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp 
    2090                 2095                 2100             


Pro Lys  Ser Lys Arg His Leu  Trp Lys Ile Ile Ser  Glu Glu Val 
    2105                 2110                 2115             


Gln Asn  Lys Cys Ser Val Ile  Leu Thr Ser His Ser  Met Glu Glu 
    2120                 2125                 2130             


Cys Glu  Ala Leu Cys Thr Arg  Leu Ala Ile Met Val  Asn Gly Lys 
    2135                 2140                 2145             


Phe Gln  Cys Ile Gly Ser Leu  Gln His Ile Lys Ser  Arg Phe Gly 
    2150                 2155                 2160             


Arg Gly  Phe Thr Val Lys Val  His Leu Lys Asn Asn  Lys Val Thr 
    2165                 2170                 2175             


Met Glu  Thr Leu Thr Lys Phe  Met Gln Leu His Phe  Pro Lys Thr 
    2180                 2185                 2190             


Tyr Leu  Lys Asp Gln His Leu  Ser Met Leu Glu Tyr  His Val Pro 
    2195                 2200                 2205             


Val Thr  Ala Gly Gly Val Ala  Asn Ile Phe Asp Leu  Leu Glu Thr 
    2210                 2215                 2220             


Asn Lys  Thr Ala Leu Asn Ile  Thr Asn Phe Leu Val  Ser Gln Thr 
    2225                 2230                 2235             


Thr Leu  Glu Glu Val Phe Ile  Asn Phe Ala Lys Asp  Gln Lys Ser 
    2240                 2245                 2250             


Tyr Glu  Thr Ala Asp Thr Ser  Ser Gln Gly Ser Thr  Ile Ser Val 
    2255                 2260                 2265             


Asp Ser  Gln Asp Asp Gln Met  Glu Ser 
    2270                 2275         


<210>  34
<211>  5058
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA13__Homo_sapiens__NP_689914

<400>  34

Met Gly His Ala Gly Cys Gln Phe Lys Ala Leu Leu Trp Lys Asn Trp 
1               5                   10                  15      


Leu Cys Arg Leu Arg Asn Pro Val Leu Phe Leu Ala Glu Phe Phe Trp 
            20                  25                  30          


Pro Cys Ile Leu Phe Val Ile Leu Thr Val Leu Arg Phe Gln Glu Pro 
        35                  40                  45              


Pro Arg Tyr Arg Asp Ile Cys Tyr Leu Gln Pro Arg Asp Leu Pro Ser 
    50                  55                  60                  


Cys Gly Val Ile Pro Phe Val Gln Ser Leu Leu Cys Asn Thr Gly Ser 
65                  70                  75                  80  


Arg Cys Arg Asn Phe Ser Tyr Glu Gly Ser Met Glu His His Phe Arg 
                85                  90                  95      


Leu Ser Arg Phe Gln Thr Ala Ala Asp Pro Lys Lys Val Asn Asn Leu 
            100                 105                 110         


Ala Phe Leu Lys Glu Ile Gln Asp Leu Ala Glu Glu Ile His Gly Met 
        115                 120                 125             


Met Asp Lys Ala Lys Asn Leu Lys Arg Leu Trp Val Glu Arg Ser Asn 
    130                 135                 140                 


Thr Pro Asp Ser Ser Tyr Gly Ser Ser Phe Phe Thr Met Asp Leu Asn 
145                 150                 155                 160 


Lys Thr Glu Glu Val Ile Leu Lys Leu Glu Ser Leu His Gln Gln Pro 
                165                 170                 175     


His Ile Trp Asp Phe Leu Leu Leu Leu Pro Arg Leu His Thr Ser His 
            180                 185                 190         


Asp His Val Glu Asp Gly Met Asp Val Ala Val Asn Leu Leu Gln Thr 
        195                 200                 205             


Ile Leu Asn Ser Leu Ile Ser Leu Glu Asp Leu Asp Trp Leu Pro Leu 
    210                 215                 220                 


Asn Gln Thr Phe Ser Gln Val Ser Glu Leu Val Leu Asn Val Thr Ile 
225                 230                 235                 240 


Ser Thr Leu Thr Phe Leu Gln Gln His Gly Val Ala Val Thr Glu Pro 
                245                 250                 255     


Val Tyr His Leu Ser Met Gln Asn Ile Val Trp Asp Pro Gln Lys Val 
            260                 265                 270         


Gln Tyr Asp Leu Lys Ser Gln Phe Gly Phe Asp Asp Leu His Thr Glu 
        275                 280                 285             


Gln Ile Leu Asn Ser Ser Ala Glu Leu Lys Glu Ile Pro Thr Asp Thr 
    290                 295                 300                 


Ser Leu Glu Lys Met Val Cys Ser Val Leu Ser Ser Thr Ser Glu Asp 
305                 310                 315                 320 


Glu Ala Glu Lys Trp Gly His Val Gly Gly Cys His Pro Lys Trp Ser 
                325                 330                 335     


Glu Ala Lys Asn Tyr Leu Val His Ala Val Ser Trp Leu Arg Val Tyr 
            340                 345                 350         


Gln Gln Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu Gln Lys Thr 
        355                 360                 365             


Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn Gln Phe Glu 
    370                 375                 380                 


Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His Thr Ala Leu 
385                 390                 395                 400 


Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys Asp Asn His 
                405                 410                 415     


Thr Phe Pro Lys Ile Leu Gln His Leu Trp Lys Leu Gln Ser Leu Leu 
            420                 425                 430         


Gln Asn Leu Pro Gln Trp Pro Ala Leu Lys Arg Phe Leu Gln Leu Asp 
        435                 440                 445             


Gly Ala Leu Arg Asn Ala Ile Ala Gln Asn Leu His Phe Val Gln Glu 
    450                 455                 460                 


Val Leu Ile Cys Leu Glu Thr Ser Ala Asn Asp Phe Lys Trp Phe Glu 
465                 470                 475                 480 


Leu Asn Gln Leu Lys Leu Glu Lys Asp Val Phe Phe Trp Glu Leu Lys 
                485                 490                 495     


Gln Met Leu Ala Lys Asn Ala Val Cys Pro Asn Gly Arg Phe Ser Glu 
            500                 505                 510         


Lys Glu Val Phe Leu Pro Pro Gly Asn Ser Ser Ile Trp Gly Gly Leu 
        515                 520                 525             


Gln Gly Leu Leu Cys Tyr Cys Asn Ser Ser Glu Thr Ser Val Leu Asn 
    530                 535                 540                 


Lys Leu Leu Gly Ser Val Glu Asp Ala Asp Arg Ile Leu Gln Glu Val 
545                 550                 555                 560 


Ile Thr Trp His Lys Asn Met Ser Val Leu Ile Pro Glu Glu Tyr Leu 
                565                 570                 575     


Asp Trp Gln Glu Leu Glu Met Gln Leu Ser Glu Ala Ser Leu Ser Cys 
            580                 585                 590         


Thr Arg Leu Phe Leu Leu Leu Gly Ala Asp Pro Ser Pro Glu Asn Asp 
        595                 600                 605             


Val Phe Ser Ser Asp Cys Lys His Gln Leu Val Ser Thr Val Ile Phe 
    610                 615                 620                 


His Thr Leu Glu Lys Thr Gln Phe Phe Leu Glu Gln Ala Tyr Tyr Trp 
625                 630                 635                 640 


Lys Ala Phe Lys Lys Phe Ile Arg Lys Thr Cys Glu Val Ala Gln Tyr 
                645                 650                 655     


Val Asn Met Gln Glu Ser Phe Gln Asn Arg Leu Leu Ala Phe Pro Glu 
            660                 665                 670         


Glu Ser Pro Cys Phe Glu Glu Asn Met Asp Trp Lys Met Ile Ser Asp 
        675                 680                 685             


Asn Tyr Phe Gln Phe Leu Asn Asn Leu Leu Lys Ser Pro Thr Ala Ser 
    690                 695                 700                 


Ile Ser Arg Ala Leu Asn Phe Thr Lys His Leu Leu Met Met Glu Lys 
705                 710                 715                 720 


Lys Leu His Thr Leu Glu Asp Glu Gln Met Asn Phe Leu Leu Ser Phe 
                725                 730                 735     


Val Glu Phe Phe Glu Lys Leu Leu Leu Pro Asn Leu Phe Asp Ser Ser 
            740                 745                 750         


Ile Val Pro Ser Phe His Ser Leu Pro Ser Leu Thr Glu Asp Ile Leu 
        755                 760                 765             


Asn Ile Ser Ser Leu Trp Thr Asn His Leu Lys Ser Leu Lys Arg Asp 
    770                 775                 780                 


Pro Ser Ala Thr Asp Ala Gln Lys Leu Leu Glu Phe Gly Asn Glu Val 
785                 790                 795                 800 


Ile Trp Lys Met Gln Thr Leu Gly Ser His Trp Ile Arg Lys Glu Pro 
                805                 810                 815     


Lys Asn Leu Leu Arg Phe Ile Glu Leu Ile Leu Phe Glu Ile Asn Pro 
            820                 825                 830         


Lys Leu Leu Glu Leu Trp Ala Tyr Gly Ile Ser Lys Gly Lys Arg Ala 
        835                 840                 845             


Lys Leu Glu Asn Phe Phe Thr Leu Leu Asn Phe Ser Val Pro Glu Asn 
    850                 855                 860                 


Glu Ile Leu Ser Thr Ser Phe Asn Phe Ser Gln Leu Phe His Ser Asp 
865                 870                 875                 880 


Trp Pro Lys Ser Pro Ala Met Asn Ile Asp Phe Val Arg Leu Ser Glu 
                885                 890                 895     


Ala Ile Ile Thr Ser Leu His Glu Phe Gly Phe Leu Glu Gln Glu Gln 
            900                 905                 910         


Ile Ser Glu Ala Leu Asn Thr Val Tyr Ala Ile Arg Asn Ala Ser Asp 
        915                 920                 925             


Leu Phe Ser Ala Leu Ser Glu Pro Gln Lys Gln Glu Val Asp Lys Ile 
    930                 935                 940                 


Leu Thr His Ile His Leu Asn Val Phe Gln Asp Lys Asp Ser Ala Leu 
945                 950                 955                 960 


Leu Leu Gln Ile Tyr Ser Ser Phe Tyr Arg Tyr Ile Tyr Glu Leu Leu 
                965                 970                 975     


Asn Ile Gln Ser Arg Gly Ser Ser Leu Thr Phe Leu Thr Gln Ile Ser 
            980                 985                 990         


Lys His Ile Leu Asp Ile Ile Lys  Gln Phe Asn Phe Gln  Asn Ile Ser 
        995                 1000                 1005             


Lys Ala  Phe Ala Phe Leu Phe  Lys Thr Ala Glu Val  Leu Gly Gly 
    1010                 1015                 1020             


Ile Ser  Asn Val Ser Tyr Cys  Gln Gln Leu Leu Ser  Ile Phe Asn 
    1025                 1030                 1035             


Phe Leu  Glu Leu Gln Ala Gln  Ser Phe Met Ser Thr  Glu Gly Gln 
    1040                 1045                 1050             


Glu Leu  Glu Val Ile His Thr  Thr Leu Thr Gly Leu  Lys Gln Leu 
    1055                 1060                 1065             


Leu Ile  Ile Asp Glu Asp Phe  Arg Ile Ser Leu Phe  Gln Tyr Met 
    1070                 1075                 1080             


Ser Gln  Phe Phe Asn Ser Ser  Val Glu Asp Leu Leu  Asp Asn Lys 
    1085                 1090                 1095             


Cys Leu  Ile Ser Asp Asn Lys  His Ile Ser Ser Val  Asn Tyr Ser 
    1100                 1105                 1110             


Thr Ser  Glu Glu Ser Ser Phe  Val Phe Pro Leu Ala  Gln Ile Phe 
    1115                 1120                 1125             


Ser Asn  Leu Ser Ala Asn Val  Ser Val Phe Asn Lys  Phe Met Ser 
    1130                 1135                 1140             


Ile His  Cys Thr Val Ser Trp  Leu Gln Met Trp Thr  Glu Ile Trp 
    1145                 1150                 1155             


Glu Thr  Ile Ser Gln Leu Phe  Lys Phe Asp Met Asn  Val Phe Thr 
    1160                 1165                 1170             


Ser Leu  His His Gly Phe Thr  Gln Leu Leu Asp Glu  Leu Glu Asp 
    1175                 1180                 1185             


Asp Val  Lys Val Ser Lys Ser  Cys Gln Gly Ile Leu  Pro Thr His 
    1190                 1195                 1200             


Asn Val  Ala Arg Leu Ile Leu  Asn Leu Phe Lys Asn  Val Thr Gln 
    1205                 1210                 1215             


Ala Asn  Asp Phe His Asn Trp  Glu Asp Phe Leu Asp  Leu Arg Asp 
    1220                 1225                 1230             


Phe Leu  Val Ala Leu Gly Asn  Ala Leu Val Ser Val  Lys Lys Leu 
    1235                 1240                 1245             


Asn Leu  Glu Gln Val Glu Lys  Ser Leu Phe Thr Met  Glu Ala Ala 
    1250                 1255                 1260             


Leu His  Gln Leu Lys Thr Phe  Pro Phe Asn Glu Ser  Thr Ser Arg 
    1265                 1270                 1275             


Glu Phe  Leu Asn Ser Leu Leu  Glu Val Phe Ile Glu  Phe Ser Ser 
    1280                 1285                 1290             


Thr Ser  Glu Tyr Ile Val Arg  Asn Leu Asp Ser Ile  Asn Asp Phe 
    1295                 1300                 1305             


Leu Ser  Asn Asn Leu Thr Asn  Tyr Gly Glu Lys Phe  Glu Asn Ile 
    1310                 1315                 1320             


Ile Thr  Glu Leu Arg Glu Ala  Ile Val Phe Leu Arg  Asn Val Ser 
    1325                 1330                 1335             


His Asp  Arg Asp Leu Phe Ser  Cys Ala Asp Ile Phe  Gln Asn Val 
    1340                 1345                 1350             


Thr Glu  Cys Ile Leu Glu Asp  Gly Phe Leu Tyr Val  Asn Thr Ser 
    1355                 1360                 1365             


Gln Arg  Met Leu Arg Ile Leu  Asp Thr Leu Asn Ser  Thr Phe Ser 
    1370                 1375                 1380             


Ser Glu  Asn Thr Ile Ser Ser  Leu Lys Gly Cys Ile  Val Trp Leu 
    1385                 1390                 1395             


Asp Val  Ile Asn His Leu Tyr  Leu Leu Ser Asn Ser  Ser Phe Ser 
    1400                 1405                 1410             


Gln Gly  His Leu Gln Asn Ile  Leu Gly Asn Phe Arg  Asp Ile Glu 
    1415                 1420                 1425             


Asn Lys  Met Asn Ser Ile Leu  Lys Ile Val Thr Trp  Val Leu Asn 
    1430                 1435                 1440             


Ile Lys  Lys Pro Leu Cys Ser  Ser Asn Gly Ser His  Ile Asn Cys 
    1445                 1450                 1455             


Val Asn  Ile Tyr Leu Lys Asp  Val Thr Asp Phe Leu  Asn Ile Val 
    1460                 1465                 1470             


Leu Thr  Thr Val Phe Glu Lys  Glu Lys Lys Pro Lys  Phe Glu Ile 
    1475                 1480                 1485             


Leu Leu  Ala Leu Leu Asn Asp  Ser Thr Lys Gln Val  Arg Met Ser 
    1490                 1495                 1500             


Ile Asn  Asn Leu Thr Thr Asp  Phe Asp Phe Ala Ser  Gln Ser Asn 
    1505                 1510                 1515             


Trp Arg  Tyr Phe Thr Glu Leu  Ile Leu Arg Pro Ile  Glu Met Ser 
    1520                 1525                 1530             


Asp Glu  Ile Pro Asn Gln Phe  Gln Asn Ile Trp Leu  His Leu Ile 
    1535                 1540                 1545             


Thr Leu  Gly Lys Glu Phe Gln  Lys Leu Val Lys Gly  Ile Tyr Phe 
    1550                 1555                 1560             


Asn Ile  Leu Glu Asn Asn Ser  Ser Ser Lys Thr Glu  Asn Leu Leu 
    1565                 1570                 1575             


Asn Ile  Phe Ala Thr Ser Pro  Lys Glu Lys Asp Val  Asn Ser Val 
    1580                 1585                 1590             


Gly Asn  Ser Ile Tyr His Leu  Ala Ser Tyr Leu Ala  Phe Ser Leu 
    1595                 1600                 1605             


Ser His  Asp Leu Gln Asn Ser  Pro Lys Ile Ile Ile  Ser Pro Glu 
    1610                 1615                 1620             


Ile Met  Lys Ala Thr Gly Leu  Gly Ile Gln Leu Ile  Arg Asp Val 
    1625                 1630                 1635             


Phe Asn  Ser Leu Met Pro Val  Val His His Thr Ser  Pro Gln Asn 
    1640                 1645                 1650             


Ala Gly  Tyr Met Gln Ala Leu  Lys Lys Val Thr Ser  Val Met Arg 
    1655                 1660                 1665             


Thr Leu  Lys Lys Ala Asp Ile  Asp Leu Leu Val Asp  Gln Leu Glu 
    1670                 1675                 1680             


Gln Val  Ser Val Asn Leu Met  Asp Phe Phe Lys Asn  Ile Ser Ser 
    1685                 1690                 1695             


Val Gly  Thr Gly Asn Leu Val  Val Asn Leu Leu Val  Gly Leu Met 
    1700                 1705                 1710             


Glu Lys  Phe Ala Asp Ser Ser  His Ser Trp Asn Val  Asn His Leu 
    1715                 1720                 1725             


Leu Gln  Leu Ser Arg Leu Phe  Pro Lys Asp Val Val  Asp Ala Val 
    1730                 1735                 1740             


Ile Asp  Val Tyr Tyr Val Leu  Pro His Ala Val Arg  Leu Leu Gln 
    1745                 1750                 1755             


Gly Val  Pro Gly Lys Asn Ile  Thr Glu Gly Leu Lys  Asp Val Tyr 
    1760                 1765                 1770             


Ser Phe  Thr Leu Leu His Gly  Ile Thr Ile Ser Asn  Ile Thr Lys 
    1775                 1780                 1785             


Glu Asp  Phe Ala Ile Val Ile  Lys Ile Leu Leu Asp  Thr Ile Glu 
    1790                 1795                 1800             


Leu Val  Ser Asp Lys Pro Asp  Ile Ile Ser Glu Ala  Leu Ala Cys 
    1805                 1810                 1815             


Phe Pro  Val Val Trp Cys Trp  Asn His Thr Asn Ser  Gly Phe Arg 
    1820                 1825                 1830             


Gln Asn  Ser Lys Ile Asp Pro  Cys Asn Val His Gly  Leu Met Ser 
    1835                 1840                 1845             


Ser Ser  Phe Tyr Gly Lys Val  Ala Ser Ile Leu Asp  His Phe His 
    1850                 1855                 1860             


Leu Ser  Pro Gln Gly Glu Asp  Ser Pro Cys Ser Asn  Glu Ser Ser 
    1865                 1870                 1875             


Arg Met  Glu Ile Thr Arg Lys  Val Val Cys Ile Ile  His Glu Leu 
    1880                 1885                 1890             


Val Asp  Trp Asn Ser Ile Leu  Leu Glu Leu Ser Glu  Val Phe His 
    1895                 1900                 1905             


Val Asn  Ile Ser Leu Val Lys  Thr Val Gln Lys Phe  Trp His Lys 
    1910                 1915                 1920             


Ile Leu  Pro Phe Val Pro Pro  Ser Ile Asn Gln Thr  Arg Asp Ser 
    1925                 1930                 1935             


Ile Ser  Glu Leu Cys Pro Ser  Gly Ser Ile Lys Gln  Val Ala Leu 
    1940                 1945                 1950             


Gln Ile  Ile Glu Lys Leu Lys  Asn Val Asn Phe Thr  Lys Val Thr 
    1955                 1960                 1965             


Ser Gly  Glu Asn Ile Leu Asp  Lys Leu Ser Ser Leu  Asn Lys Ile 
    1970                 1975                 1980             


Leu Asn  Ile Asn Glu Asp Thr  Glu Thr Ser Val Gln  Asn Ile Ile 
    1985                 1990                 1995             


Ser Ser  Asn Leu Glu Arg Thr  Val Gln Leu Ile Ser  Glu Asp Trp 
    2000                 2005                 2010             


Ser Leu  Glu Lys Ser Thr His  Asn Leu Leu Ser Leu  Phe Met Met 
    2015                 2020                 2025             


Leu Gln  Asn Ala Asn Val Thr  Gly Ser Ser Leu Glu  Ala Leu Ser 
    2030                 2035                 2040             


Ser Phe  Ile Glu Lys Ser Glu  Thr Pro Tyr Asn Phe  Glu Glu Leu 
    2045                 2050                 2055             


Trp Pro  Lys Phe Gln Gln Ile  Met Lys Asp Leu Thr  Gln Asp Phe 
    2060                 2065                 2070             


Arg Ile  Arg His Leu Leu Ser  Glu Met Asn Lys Gly  Ile Lys Ser 
    2075                 2080                 2085             


Ile Asn  Ser Met Ala Leu Gln  Lys Ile Thr Leu Gln  Phe Ala His 
    2090                 2095                 2100             


Phe Leu  Glu Ile Leu Asp Ser  Pro Ser Leu Lys Thr  Leu Glu Ile 
    2105                 2110                 2115             


Ile Glu  Asp Phe Leu Leu Val  Thr Lys Asn Trp Leu  Gln Glu Tyr 
    2120                 2125                 2130             


Ala Asn  Glu Asp Tyr Ser Arg  Met Ile Glu Thr Leu  Phe Ile Pro 
    2135                 2140                 2145             


Val Thr  Asn Glu Ser Ser Thr  Glu Asp Ile Ala Leu  Leu Ala Lys 
    2150                 2155                 2160             


Ala Ile  Ala Thr Phe Trp Gly  Ser Leu Lys Asn Ile  Ser Arg Ala 
    2165                 2170                 2175             


Gly Asn  Phe Asp Val Ala Phe  Leu Thr His Leu Leu  Asn Gln Glu 
    2180                 2185                 2190             


Gln Leu  Thr Asn Phe Ser Val  Val Gln Leu Leu Phe  Glu Asn Ile 
    2195                 2200                 2205             


Leu Ile  Asn Leu Ile Asn Asn  Leu Ala Gly Asn Ser  Gln Glu Ala 
    2210                 2215                 2220             


Ala Trp  Asn Leu Asn Asp Thr  Asp Leu Gln Ile Met  Asn Phe Ile 
    2225                 2230                 2235             


Asn Leu  Ile Leu Asn His Met  Gln Ser Glu Thr Ser  Arg Lys Thr 
    2240                 2245                 2250             


Val Leu  Ser Leu Arg Ser Ile  Val Asp Phe Thr Glu  Gln Phe Leu 
    2255                 2260                 2265             


Lys Thr  Phe Phe Ser Leu Phe  Leu Lys Glu Asp Ser  Glu Asn Lys 
    2270                 2275                 2280             


Ile Ser  Leu Leu Leu Lys Tyr  Phe His Lys Asp Val  Ile Ala Glu 
    2285                 2290                 2295             


Met Ser  Phe Val Pro Lys Asp  Lys Ile Leu Glu Ile  Leu Lys Leu 
    2300                 2305                 2310             


Asp Gln  Phe Leu Thr Leu Met  Ile Gln Asp Arg Leu  Met Asn Ile 
    2315                 2320                 2325             


Phe Ser  Ser Leu Lys Glu Thr  Ile Tyr His Leu Met  Lys Ser Ser 
    2330                 2335                 2340             


Phe Ile  Leu Asp Asn Gly Glu  Phe Tyr Phe Asp Thr  His Gln Gly 
    2345                 2350                 2355             


Leu Lys  Phe Met Gln Asp Leu  Phe Asn Ala Leu Leu  Arg Glu Thr 
    2360                 2365                 2370             


Ser Met  Lys Asn Lys Thr Glu  Asn Asn Ile Asp Phe  Phe Thr Val 
    2375                 2380                 2385             


Val Ser  Gln Leu Phe Phe His  Val Asn Lys Ser Glu  Asp Leu Phe 
    2390                 2395                 2400             


Lys Leu  Asn Gln Asp Leu Gly  Ser Ala Leu His Leu  Val Arg Glu 
    2405                 2410                 2415             


Cys Ser  Thr Glu Met Ala Arg  Leu Leu Asp Thr Ile  Leu His Ser 
    2420                 2425                 2430             


Pro Asn  Lys Asp Phe Tyr Ala  Leu Tyr Pro Thr Leu  Gln Glu Val 
    2435                 2440                 2445             


Ile Leu  Ala Asn Leu Thr Asp  Leu Leu Phe Phe Ile  Asn Asn Ser 
    2450                 2455                 2460             


Phe Pro  Leu Arg Asn Arg Ala  Thr Leu Glu Ile Thr  Lys Arg Leu 
    2465                 2470                 2475             


Val Gly  Ala Ile Ser Arg Ala  Ser Glu Glu Ser His  Val Leu Lys 
    2480                 2485                 2490             


Pro Leu  Leu Glu Met Ser Gly  Thr Leu Val Met Leu  Leu Asn Asp 
    2495                 2500                 2505             


Ser Ala  Asp Leu Arg Asp Leu  Ala Thr Ser Met Asp  Ser Ile Val 
    2510                 2515                 2520             


Lys Leu  Leu Lys Leu Val Lys  Lys Val Ser Gly Lys  Met Ser Thr 
    2525                 2530                 2535             


Val Phe  Lys Thr His Phe Ile  Ser Asn Thr Lys Asp  Ser Val Lys 
    2540                 2545                 2550             


Phe Phe  Asp Thr Leu Tyr Ser  Ile Met Gln Gln Ser  Val Gln Asn 
    2555                 2560                 2565             


Leu Val  Lys Glu Ile Ala Thr  Leu Lys Lys Ile Asp  His Phe Thr 
    2570                 2575                 2580             


Phe Glu  Lys Ile Asn Asp Leu  Leu Val Pro Phe Leu  Asp Leu Ala 
    2585                 2590                 2595             


Phe Glu  Met Ile Gly Val Glu  Pro Tyr Ile Ser Ser  Asn Ser Asp 
    2600                 2605                 2610             


Ile Phe  Ser Met Ser Pro Ser  Ile Leu Ser Tyr Met  Asn Gln Ser 
    2615                 2620                 2625             


Lys Asp  Phe Ser Asp Ile Leu  Glu Glu Ile Ala Glu  Phe Leu Thr 
    2630                 2635                 2640             


Ser Val  Lys Met Asn Leu Glu  Asp Met Arg Ser Leu  Ala Val Ala 
    2645                 2650                 2655             


Phe Asn  Asn Glu Thr Gln Thr  Phe Ser Met Asp Ser  Val Asn Leu 
    2660                 2665                 2670             


Arg Glu  Glu Ile Leu Gly Cys  Leu Val Pro Ile Asn  Asn Ile Thr 
    2675                 2680                 2685             


Asn Gln  Met Asp Phe Leu Tyr  Pro Asn Pro Ile Ser  Thr His Ser 
    2690                 2695                 2700             


Gly Pro  Gln Asp Ile Lys Trp  Glu Ile Ile His Glu  Val Ile Pro 
    2705                 2710                 2715             


Phe Leu  Asp Lys Ile Leu Ser  Gln Asn Ser Thr Glu  Ile Gly Ser 
    2720                 2725                 2730             


Phe Leu  Lys Met Val Ile Cys  Leu Thr Leu Glu Ala  Leu Trp Lys 
    2735                 2740                 2745             


Asn Leu  Lys Lys Asp Asn Trp  Asn Val Ser Asn Val  Leu Met Thr 
    2750                 2755                 2760             


Phe Thr  Gln His Pro Asn Asn  Leu Leu Lys Thr Ile  Glu Thr Val 
    2765                 2770                 2775             


Leu Glu  Ala Ser Ser Gly Ile  Lys Ser Asp Tyr Glu  Gly Asp Leu 
    2780                 2785                 2790             


Asn Lys  Ser Leu Tyr Phe Asp  Thr Pro Leu Ser Gln  Asn Ile Thr 
    2795                 2800                 2805             


His His  Gln Leu Glu Lys Ala  Ile His Asn Val Leu  Ser Arg Ile 
    2810                 2815                 2820             


Ala Leu  Trp Arg Lys Gly Leu  Leu Phe Asn Asn Ser  Glu Trp Ile 
    2825                 2830                 2835             


Thr Ser  Thr Arg Thr Leu Phe  Gln Pro Leu Phe Glu  Ile Phe Ile 
    2840                 2845                 2850             


Lys Ala  Thr Thr Gly Lys Asn  Val Thr Ser Glu Lys  Glu Glu Arg 
    2855                 2860                 2865             


Thr Lys  Lys Glu Met Ile Asp  Phe Pro Tyr Ser Phe  Lys Pro Phe 
    2870                 2875                 2880             


Phe Cys  Leu Glu Lys Tyr Leu  Gly Gly Leu Phe Val  Leu Thr Lys 
    2885                 2890                 2895             


Tyr Trp  Gln Gln Ile Pro Leu  Thr Asp Gln Ser Val  Val Glu Ile 
    2900                 2905                 2910             


Cys Glu  Val Phe Gln Gln Thr  Val Lys Pro Ser Glu  Ala Met Glu 
    2915                 2920                 2925             


Met Leu  Gln Lys Val Lys Met  Met Val Val Arg Val  Leu Thr Ile 
    2930                 2935                 2940             


Val Ala  Glu Asn Pro Ser Trp  Thr Lys Asp Ile Leu  Cys Ala Thr 
    2945                 2950                 2955             


Leu Ser  Cys Lys Gln Asn Gly  Ile Arg His Leu Ile  Leu Ser Ala 
    2960                 2965                 2970             


Ile Gln  Gly Val Thr Leu Ala  Gln Asp His Phe Gln  Glu Ile Glu 
    2975                 2980                 2985             


Lys Ile  Trp Ser Ser Pro Asn  Gln Leu Asn Cys Glu  Ser Leu Ser 
    2990                 2995                 3000             


Lys Asn  Leu Ser Ser Thr Leu  Glu Ser Phe Lys Ser  Ser Leu Glu 
    3005                 3010                 3015             


Asn Ala  Thr Gly Gln Asp Cys  Thr Ser Gln Pro Arg  Leu Glu Thr 
    3020                 3025                 3030             


Val Gln  Gln His Leu Tyr Met  Leu Ala Lys Ser Leu  Glu Glu Thr 
    3035                 3040                 3045             


Trp Ser  Ser Gly Asn Pro Ile  Met Thr Phe Leu Ser  Asn Phe Thr 
    3050                 3055                 3060             


Val Thr  Glu Asp Val Lys Ile  Lys Asp Leu Met Lys  Asn Ile Thr 
    3065                 3070                 3075             


Lys Leu  Thr Glu Glu Leu Arg  Ser Ser Ile Gln Ile  Ser Asn Glu 
    3080                 3085                 3090             


Thr Ile  His Ser Ile Leu Glu  Ala Asn Ile Ser His  Ser Lys Val 
    3095                 3100                 3105             


Leu Phe  Ser Ala Leu Thr Val  Ala Leu Ser Gly Lys  Cys Asp Gln 
    3110                 3115                 3120             


Glu Ile  Leu His Leu Leu Leu  Thr Phe Pro Lys Gly  Glu Lys Ser 
    3125                 3130                 3135             


Trp Ile  Ala Ala Glu Glu Leu  Cys Ser Leu Pro Gly  Ser Lys Val 
    3140                 3145                 3150             


Tyr Ser  Leu Ile Val Leu Leu  Ser Arg Asn Leu Asp  Val Arg Ala 
    3155                 3160                 3165             


Phe Ile  Tyr Lys Thr Leu Met  Pro Ser Glu Ala Asn  Gly Leu Leu 
    3170                 3175                 3180             


Asn Ser  Leu Leu Asp Ile Val  Ser Ser Leu Ser Ala  Leu Leu Ala 
    3185                 3190                 3195             


Lys Ala  Gln His Val Phe Glu  Tyr Leu Pro Glu Phe  Leu His Thr 
    3200                 3205                 3210             


Phe Lys  Ile Thr Ala Leu Leu  Glu Thr Leu Asp Phe  Gln Gln Val 
    3215                 3220                 3225             


Ser Gln  Asn Val Gln Ala Arg  Ser Ser Ala Phe Gly  Ser Phe Gln 
    3230                 3235                 3240             


Phe Val  Met Lys Met Val Cys  Lys Asp Gln Ala Ser  Phe Leu Ser 
    3245                 3250                 3255             


Asp Ser  Asn Met Phe Ile Asn  Leu Pro Arg Val Lys  Glu Leu Leu 
    3260                 3265                 3270             


Glu Asp  Asp Lys Glu Lys Phe  Asn Ile Pro Glu Asp  Ser Thr Pro 
    3275                 3280                 3285             


Phe Cys  Leu Lys Leu Tyr Gln  Glu Ile Leu Gln Leu  Pro Asn Gly 
    3290                 3295                 3300             


Ala Leu  Val Trp Thr Phe Leu  Lys Pro Ile Leu His  Gly Lys Ile 
    3305                 3310                 3315             


Leu Tyr  Thr Pro Asn Thr Pro  Glu Ile Asn Lys Val  Ile Gln Lys 
    3320                 3325                 3330             


Ala Asn  Tyr Thr Phe Tyr Ile  Val Asp Lys Leu Lys  Thr Leu Ser 
    3335                 3340                 3345             


Glu Thr  Leu Leu Glu Met Ser  Ser Leu Phe Gln Arg  Ser Gly Ser 
    3350                 3355                 3360             


Gly Gln  Met Phe Asn Gln Leu  Gln Glu Ala Leu Arg  Asn Lys Phe 
    3365                 3370                 3375             


Val Arg  Asn Phe Val Glu Asn  Gln Leu His Ile Asp  Val Asp Lys 
    3380                 3385                 3390             


Leu Thr  Glu Lys Leu Gln Thr  Tyr Gly Gly Leu Leu  Asp Glu Met 
    3395                 3400                 3405             


Phe Asn  His Ala Gly Ala Gly  Arg Phe Arg Phe Leu  Gly Ser Ile 
    3410                 3415                 3420             


Leu Val  Asn Leu Ser Ser Cys  Val Ala Leu Asn Arg  Phe Gln Ala 
    3425                 3430                 3435             


Leu Gln  Ser Val Asp Ile Leu  Glu Thr Lys Ala His  Glu Leu Leu 
    3440                 3445                 3450             


Gln Gln  Asn Ser Phe Leu Ala  Ser Ile Ile Phe Ser  Asn Ser Leu 
    3455                 3460                 3465             


Phe Asp  Lys Asn Phe Arg Ser  Glu Ser Val Lys Leu  Pro Pro His 
    3470                 3475                 3480             


Val Ser  Tyr Thr Ile Arg Thr  Asn Val Leu Tyr Ser  Val Arg Thr 
    3485                 3490                 3495             


Asp Val  Val Lys Asn Pro Ser  Trp Lys Phe His Pro  Gln Asn Leu 
    3500                 3505                 3510             


Pro Ala  Asp Gly Phe Lys Tyr  Asn Tyr Val Phe Ala  Pro Leu Gln 
    3515                 3520                 3525             


Asp Met  Ile Glu Arg Ala Ile  Ile Leu Val Gln Thr  Gly Gln Glu 
    3530                 3535                 3540             


Ala Leu  Glu Pro Ala Ala Gln  Thr Gln Ala Ala Pro  Tyr Pro Cys 
    3545                 3550                 3555             


His Thr  Ser Asp Leu Phe Leu  Asn Asn Val Gly Phe  Phe Phe Pro 
    3560                 3565                 3570             


Leu Ile  Met Met Leu Thr Trp  Met Val Ser Val Ala  Ser Met Val 
    3575                 3580                 3585             


Arg Lys  Leu Val Tyr Glu Gln  Glu Ile Gln Ile Glu  Glu Tyr Met 
    3590                 3595                 3600             


Arg Met  Met Gly Val His Pro  Val Ile His Phe Leu  Ala Trp Phe 
    3605                 3610                 3615             


Leu Glu  Asn Met Ala Val Leu  Thr Ile Ser Ser Ala  Thr Leu Ala 
    3620                 3625                 3630             


Ile Val  Leu Lys Thr Ser Gly  Ile Phe Ala His Ser  Asn Thr Phe 
    3635                 3640                 3645             


Ile Val  Phe Leu Phe Leu Leu  Asp Phe Gly Met Ser  Val Val Met 
    3650                 3655                 3660             


Leu Ser  Tyr Leu Leu Ser Ala  Phe Phe Ser Gln Ala  Asn Thr Ala 
    3665                 3670                 3675             


Ala Leu  Cys Thr Ser Leu Val  Tyr Met Ile Ser Phe  Leu Pro Tyr 
    3680                 3685                 3690             


Ile Val  Leu Leu Val Leu His  Asn Gln Leu Ser Phe  Val Asn Gln 
    3695                 3700                 3705             


Thr Phe  Leu Cys Leu Leu Ser  Thr Thr Ala Phe Gly  Gln Gly Val 
    3710                 3715                 3720             


Phe Phe  Ile Thr Phe Leu Glu  Gly Gln Glu Thr Gly  Ile Gln Trp 
    3725                 3730                 3735             


Asn Asn  Met Tyr Gln Ala Leu  Glu Gln Gly Gly Met  Thr Phe Gly 
    3740                 3745                 3750             


Trp Val  Cys Trp Met Ile Leu  Phe Asp Ser Ser Leu  Tyr Phe Leu 
    3755                 3760                 3765             


Cys Gly  Trp Tyr Leu Ser Asn  Leu Ile Pro Gly Thr  Phe Gly Leu 
    3770                 3775                 3780             


Arg Lys  Pro Trp Tyr Phe Pro  Phe Thr Ala Ser Tyr  Trp Lys Ser 
    3785                 3790                 3795             


Val Gly  Phe Leu Val Glu Lys  Arg Gln Tyr Phe Leu  Ser Ser Ser 
    3800                 3805                 3810             


Leu Phe  Phe Phe Asn Glu Asn  Phe Asp Asn Lys Gly  Ser Ser Leu 
    3815                 3820                 3825             


Gln Asn  Arg Glu Gly Glu Leu  Glu Gly Ser Ala Pro  Gly Val Thr 
    3830                 3835                 3840             


Leu Val  Ser Val Thr Lys Glu  Tyr Glu Gly His Lys  Ala Val Val 
    3845                 3850                 3855             


Gln Asp  Leu Ser Leu Thr Phe  Tyr Arg Asp Gln Ile  Thr Ala Leu 
    3860                 3865                 3870             


Leu Gly  Thr Asn Gly Ala Gly  Lys Thr Thr Ile Ile  Ser Met Leu 
    3875                 3880                 3885             


Thr Gly  Leu His Pro Pro Thr  Ser Gly Thr Ile Ile  Ile Asn Gly 
    3890                 3895                 3900             


Lys Asn  Leu Gln Thr Asp Leu  Ser Arg Val Arg Met  Glu Leu Gly 
    3905                 3910                 3915             


Val Cys  Pro Gln Gln Asp Ile  Leu Leu Asp Asn Leu  Thr Val Arg 
    3920                 3925                 3930             


Glu His  Leu Leu Leu Phe Ala  Ser Ile Lys Ala Pro  Gln Trp Thr 
    3935                 3940                 3945             


Lys Lys  Glu Leu His Gln Gln  Val Asn Gln Thr Leu  Gln Asp Val 
    3950                 3955                 3960             


Asp Leu  Thr Gln His Gln His  Lys Gln Thr Arg Ala  Leu Ser Gly 
    3965                 3970                 3975             


Gly Leu  Lys Arg Lys Leu Ser  Leu Gly Ile Ala Phe  Met Gly Met 
    3980                 3985                 3990             


Ser Arg  Thr Val Val Leu Asp  Glu Pro Thr Ser Gly  Val Asp Pro 
    3995                 4000                 4005             


Cys Ser  Arg His Ser Leu Trp  Asp Ile Leu Leu Lys  Tyr Arg Glu 
    4010                 4015                 4020             


Gly Arg  Thr Ile Ile Phe Thr  Thr His His Leu Asp  Glu Ala Glu 
    4025                 4030                 4035             


Ala Leu  Ser Asp Arg Val Ala  Val Leu Gln His Gly  Arg Leu Arg 
    4040                 4045                 4050             


Cys Cys  Gly Pro Pro Phe Cys  Leu Lys Glu Ala Tyr  Gly Gln Gly 
    4055                 4060                 4065             


Leu Arg  Leu Thr Leu Thr Arg  Gln Pro Ser Val Leu  Glu Ala His 
    4070                 4075                 4080             


Asp Leu  Lys Asp Met Ala Cys  Val Thr Ser Leu Ile  Lys Ile Tyr 
    4085                 4090                 4095             


Ile Pro  Gln Ala Phe Leu Lys  Asp Ser Ser Gly Ser  Glu Leu Thr 
    4100                 4105                 4110             


Tyr Thr  Ile Pro Lys Asp Thr  Asp Lys Ala Cys Leu  Lys Gly Leu 
    4115                 4120                 4125             


Phe Gln  Ala Leu Asp Glu Asn  Leu His Gln Leu His  Leu Thr Gly 
    4130                 4135                 4140             


Tyr Gly  Ile Ser Asp Thr Thr  Leu Glu Glu Val Phe  Leu Met Leu 
    4145                 4150                 4155             


Leu Gln  Asp Ser Asn Lys Lys  Ser His Ile Ala Leu  Gly Thr Glu 
    4160                 4165                 4170             


Ser Glu  Leu Gln Asn His Arg  Pro Thr Gly His Leu  Ser Gly Tyr 
    4175                 4180                 4185             


Cys Gly  Ser Leu Ala Arg Pro  Ala Thr Val Gln Gly  Val Gln Leu 
    4190                 4195                 4200             


Leu Arg  Ala Gln Val Ala Ala  Ile Leu Ala Arg Arg  Leu Arg Arg 
    4205                 4210                 4215             


Thr Leu  Arg Ala Gly Lys Ser  Thr Leu Ala Asp Leu  Leu Leu Pro 
    4220                 4225                 4230             


Val Leu  Phe Val Ala Leu Ala  Met Gly Leu Phe Met  Val Arg Pro 
    4235                 4240                 4245             


Leu Ala  Thr Glu Tyr Pro Pro  Leu Arg Leu Thr Pro  Gly His Tyr 
    4250                 4255                 4260             


Gln Arg  Ala Glu Thr Tyr Phe  Phe Ser Ser Gly Gly  Asp Asn Leu 
    4265                 4270                 4275             


Asp Leu  Thr Arg Val Leu Leu  Arg Lys Phe Arg Asp  Gln Asp Leu 
    4280                 4285                 4290             


Pro Cys  Ala Asp Leu Asn Pro  Arg Gln Lys Asn Ser  Ser Cys Trp 
    4295                 4300                 4305             


Arg Thr  Asp Pro Phe Ser His  Pro Glu Phe Gln Asp  Ser Cys Gly 
    4310                 4315                 4320             


Cys Leu  Lys Cys Pro Asn Arg  Ser Ala Ser Ala Pro  Tyr Leu Thr 
    4325                 4330                 4335             


Asn His  Leu Gly His Thr Leu  Leu Asn Leu Ser Gly  Phe Asn Met 
    4340                 4345                 4350             


Glu Glu  Tyr Leu Leu Ala Pro  Ser Glu Lys Pro Arg  Leu Gly Gly 
    4355                 4360                 4365             


Trp Ser  Phe Gly Leu Lys Ile  Pro Ser Glu Ala Gly  Gly Ala Asn 
    4370                 4375                 4380             


Gly Asn  Ile Ser Lys Pro Pro  Thr Leu Ala Lys Val  Trp Tyr Asn 
    4385                 4390                 4395             


Gln Lys  Gly Phe His Ser Leu  Pro Ser Tyr Leu Asn  His Leu Asn 
    4400                 4405                 4410             


Asn Leu  Ile Leu Trp Gln His  Leu Pro Pro Thr Val  Asp Trp Arg 
    4415                 4420                 4425             


Gln Tyr  Gly Ile Thr Leu Tyr  Ser His Pro Tyr Gly  Gly Ala Leu 
    4430                 4435                 4440             


Leu Asn  Glu Asp Lys Ile Leu  Glu Ser Ile Arg Gln  Cys Gly Val 
    4445                 4450                 4455             


Ala Leu  Cys Ile Val Leu Gly  Phe Ser Ile Leu Ser  Ala Ser Ile 
    4460                 4465                 4470             


Gly Ser  Ser Val Val Arg Asp  Arg Val Ile Gly Ala  Lys Arg Leu 
    4475                 4480                 4485             


Gln His  Ile Ser Gly Leu Gly  Tyr Arg Met Tyr Trp  Phe Thr Asn 
    4490                 4495                 4500             


Phe Leu  Tyr Asp Met Leu Phe  Tyr Leu Val Ser Val  Cys Leu Cys 
    4505                 4510                 4515             


Val Ala  Val Ile Val Ala Phe  Gln Leu Thr Ala Phe  Thr Phe Arg 
    4520                 4525                 4530             


Lys Asn  Leu Ala Ala Thr Ala  Leu Leu Leu Ser Leu  Phe Gly Tyr 
    4535                 4540                 4545             


Ala Thr  Leu Pro Trp Met Tyr  Leu Met Ser Arg Ile  Phe Ser Ser 
    4550                 4555                 4560             


Ser Asp  Val Ala Phe Ile Ser  Tyr Val Ser Leu Asn  Phe Ile Phe 
    4565                 4570                 4575             


Gly Leu  Cys Thr Met Leu Ile  Thr Ile Met Pro Arg  Leu Leu Ala 
    4580                 4585                 4590             


Ile Ile  Ser Lys Ala Lys Asn  Leu Gln Asn Ile Tyr  Asp Val Leu 
    4595                 4600                 4605             


Lys Trp  Val Phe Thr Ile Phe  Pro Gln Phe Cys Leu  Gly Gln Gly 
    4610                 4615                 4620             


Leu Val  Glu Leu Cys Tyr Asn  Gln Ile Lys Tyr Asp  Leu Thr His 
    4625                 4630                 4635             


Asn Phe  Gly Ile Asp Ser Tyr  Val Ser Pro Phe Glu  Met Asn Phe 
    4640                 4645                 4650             


Leu Gly  Trp Ile Phe Val Gln  Leu Ala Ser Gln Gly  Thr Val Leu 
    4655                 4660                 4665             


Leu Leu  Leu Arg Val Leu Leu  His Trp Asp Leu Leu  Arg Trp Pro 
    4670                 4675                 4680             


Arg Gly  His Ser Thr Leu Gln  Gly Thr Val Lys Ser  Ser Lys Asp 
    4685                 4690                 4695             


Thr Asp  Val Glu Lys Glu Glu  Lys Arg Val Phe Glu  Gly Arg Thr 
    4700                 4705                 4710             


Asn Gly  Asp Ile Leu Val Leu  Tyr Asn Leu Ser Lys  His Tyr Arg 
    4715                 4720                 4725             


Arg Phe  Phe Gln Asn Ile Ile  Ala Val Gln Asp Ile  Ser Leu Gly 
    4730                 4735                 4740             


Ile Pro  Lys Gly Glu Cys Phe  Gly Leu Leu Gly Val  Asn Gly Ala 
    4745                 4750                 4755             


Gly Lys  Ser Thr Thr Phe Lys  Met Leu Asn Gly Glu  Val Ser Leu 
    4760                 4765                 4770             


Thr Ser  Gly His Ala Ile Ile  Arg Thr Pro Met Gly  Asp Ala Val 
    4775                 4780                 4785             


Asp Leu  Ser Ser Ala Gly Thr  Ala Gly Val Leu Ile  Gly Tyr Cys 
    4790                 4795                 4800             


Pro Gln  Gln Asp Ala Leu Asp  Glu Leu Leu Thr Gly  Trp Glu His 
    4805                 4810                 4815             


Leu Tyr  Tyr Tyr Cys Ser Leu  Arg Gly Ile Pro Arg  Gln Cys Ile 
    4820                 4825                 4830             


Pro Glu  Val Ala Gly Asp Leu  Ile Arg Arg Leu His  Leu Glu Ala 
    4835                 4840                 4845             


His Ala  Asp Lys Pro Val Ala  Thr Tyr Ser Gly Gly  Thr Lys Arg 
    4850                 4855                 4860             


Lys Leu  Ser Thr Ala Leu Ala  Leu Val Gly Lys Pro  Asp Ile Leu 
    4865                 4870                 4875             


Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp Pro Cys  Ser Lys Arg 
    4880                 4885                 4890             


Tyr Leu  Trp Gln Thr Ile Met  Lys Glu Val Arg Glu  Gly Cys Ala 
    4895                 4900                 4905             


Ala Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    4910                 4915                 4920             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Ser Phe Lys  Cys Leu Gly 
    4925                 4930                 4935             


Ser Pro  Gln His Ile Lys Asn  Arg Phe Gly Asp Gly  Tyr Thr Val 
    4940                 4945                 4950             


Lys Val  Trp Leu Cys Lys Glu  Ala Asn Gln His Cys  Thr Val Ser 
    4955                 4960                 4965             


Asp His  Leu Lys Leu Tyr Phe  Pro Gly Ile Gln Phe  Lys Gly Gln 
    4970                 4975                 4980             


His Leu  Asn Leu Leu Glu Tyr  His Val Pro Lys Arg  Trp Gly Cys 
    4985                 4990                 4995             


Leu Ala  Asp Leu Phe Lys Val  Ile Glu Asn Asn Lys  Thr Phe Leu 
    5000                 5005                 5010             


Asn Ile  Lys His Tyr Ser Ile  Asn Gln Thr Thr Leu  Glu Gln Val 
    5015                 5020                 5025             


Phe Ile  Asn Phe Ala Ser Glu  Gln Gln Gln Thr Leu  Gln Ser Thr 
    5030                 5035                 5040             


Leu Asp  Pro Ser Thr Asp Ser  His His Thr His His  Leu Pro Ile 
    5045                 5050                 5055             


<210>  35
<211>  2261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA1__Homo_sapiens__NP_005493

<400>  35

Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210>  36
<211>  2436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA2__Homo_sapiens__NP_001597

<400>  36

Met Gly Phe Leu His Gln Leu Gln Leu Leu Leu Trp Lys Asn Val Thr 
1               5                   10                  15      


Leu Lys Arg Arg Ser Pro Trp Val Leu Ala Phe Glu Ile Phe Ile Pro 
            20                  25                  30          


Leu Val Leu Phe Phe Ile Leu Leu Gly Leu Arg Gln Lys Lys Pro Thr 
        35                  40                  45              


Ile Ser Val Lys Glu Val Ser Phe Tyr Thr Ala Ala Pro Leu Thr Ser 
    50                  55                  60                  


Ala Gly Ile Leu Pro Val Met Gln Ser Leu Cys Pro Asp Gly Gln Arg 
65                  70                  75                  80  


Asp Glu Phe Gly Phe Leu Gln Tyr Ala Asn Ser Thr Val Thr Gln Leu 
                85                  90                  95      


Leu Glu Arg Leu Asp Arg Val Val Glu Glu Gly Asn Leu Phe Asp Pro 
            100                 105                 110         


Ala Arg Pro Ser Leu Gly Ser Glu Leu Glu Ala Leu Arg Gln His Leu 
        115                 120                 125             


Glu Ala Leu Ser Ala Gly Pro Gly Thr Ser Gly Ser His Leu Asp Arg 
    130                 135                 140                 


Ser Thr Val Ser Ser Phe Ser Leu Asp Ser Val Ala Arg Asn Pro Gln 
145                 150                 155                 160 


Glu Leu Trp Arg Phe Leu Thr Gln Asn Leu Ser Leu Pro Asn Ser Thr 
                165                 170                 175     


Ala Gln Ala Leu Leu Ala Ala Arg Val Asp Pro Pro Glu Val Tyr His 
            180                 185                 190         


Leu Leu Phe Gly Pro Ser Ser Ala Leu Asp Ser Gln Ser Gly Leu His 
        195                 200                 205             


Lys Gly Gln Glu Pro Trp Ser Arg Leu Gly Gly Asn Pro Leu Phe Arg 
    210                 215                 220                 


Met Glu Glu Leu Leu Leu Ala Pro Ala Leu Leu Glu Gln Leu Thr Cys 
225                 230                 235                 240 


Thr Pro Gly Ser Gly Glu Leu Gly Arg Ile Leu Thr Val Pro Glu Ser 
                245                 250                 255     


Gln Lys Gly Ala Leu Gln Gly Tyr Arg Asp Ala Val Cys Ser Gly Gln 
            260                 265                 270         


Ala Ala Ala Arg Ala Arg Arg Phe Ser Gly Leu Ser Ala Glu Leu Arg 
        275                 280                 285             


Asn Gln Leu Asp Val Ala Lys Val Ser Gln Gln Leu Gly Leu Asp Ala 
    290                 295                 300                 


Pro Asn Gly Ser Asp Ser Ser Pro Gln Ala Pro Pro Pro Arg Arg Leu 
305                 310                 315                 320 


Gln Ala Leu Leu Gly Asp Leu Leu Asp Ala Gln Lys Val Leu Gln Asp 
                325                 330                 335     


Val Asp Val Leu Ser Ala Leu Ala Leu Leu Leu Pro Gln Gly Ala Cys 
            340                 345                 350         


Thr Gly Arg Thr Pro Gly Pro Pro Ala Ser Gly Ala Gly Gly Ala Ala 
        355                 360                 365             


Asn Gly Thr Gly Ala Gly Ala Val Met Gly Pro Asn Ala Thr Ala Glu 
    370                 375                 380                 


Glu Gly Ala Pro Ser Ala Ala Ala Leu Ala Thr Pro Asp Thr Leu Gln 
385                 390                 395                 400 


Gly Gln Cys Ser Ala Phe Val Gln Leu Trp Ala Gly Leu Gln Pro Ile 
                405                 410                 415     


Leu Cys Gly Asn Asn Arg Thr Ile Glu Pro Glu Ala Leu Arg Arg Gly 
            420                 425                 430         


Asn Met Ser Ser Leu Gly Phe Thr Ser Lys Glu Gln Arg Asn Leu Gly 
        435                 440                 445             


Leu Leu Val His Leu Met Thr Ser Asn Pro Lys Ile Leu Tyr Ala Pro 
    450                 455                 460                 


Ala Gly Ser Glu Val Asp Arg Val Ile Leu Lys Ala Asn Glu Thr Phe 
465                 470                 475                 480 


Ala Phe Val Gly Asn Val Thr His Tyr Ala Gln Val Trp Leu Asn Ile 
                485                 490                 495     


Ser Ala Glu Ile Arg Ser Phe Leu Glu Gln Gly Arg Leu Gln Gln His 
            500                 505                 510         


Leu Arg Trp Leu Gln Gln Tyr Val Ala Glu Leu Arg Leu His Pro Glu 
        515                 520                 525             


Ala Leu Asn Leu Ser Leu Asp Glu Leu Pro Pro Ala Leu Arg Gln Asp 
    530                 535                 540                 


Asn Phe Ser Leu Pro Ser Gly Met Ala Leu Leu Gln Gln Leu Asp Thr 
545                 550                 555                 560 


Ile Asp Asn Ala Ala Cys Gly Trp Ile Gln Phe Met Ser Lys Val Ser 
                565                 570                 575     


Val Asp Ile Phe Lys Gly Phe Pro Asp Glu Glu Ser Ile Val Asn Tyr 
            580                 585                 590         


Thr Leu Asn Gln Ala Tyr Gln Asp Asn Val Thr Val Phe Ala Ser Val 
        595                 600                 605             


Ile Phe Gln Thr Arg Lys Asp Gly Ser Leu Pro Pro His Val His Tyr 
    610                 615                 620                 


Lys Ile Arg Gln Asn Ser Ser Phe Thr Glu Lys Thr Asn Glu Ile Arg 
625                 630                 635                 640 


Arg Ala Tyr Trp Arg Pro Gly Pro Asn Thr Gly Gly Arg Phe Tyr Phe 
                645                 650                 655     


Leu Tyr Gly Phe Val Trp Ile Gln Asp Met Met Glu Arg Ala Ile Ile 
            660                 665                 670         


Asp Thr Phe Val Gly His Asp Val Val Glu Pro Gly Ser Tyr Val Gln 
        675                 680                 685             


Met Phe Pro Tyr Pro Cys Tyr Thr Arg Asp Asp Phe Leu Phe Val Ile 
    690                 695                 700                 


Glu His Met Met Pro Leu Cys Met Val Ile Ser Trp Val Tyr Ser Val 
705                 710                 715                 720 


Ala Met Thr Ile Gln His Ile Val Ala Glu Lys Glu His Arg Leu Lys 
                725                 730                 735     


Glu Val Met Lys Thr Met Gly Leu Asn Asn Ala Val His Trp Val Ala 
            740                 745                 750         


Trp Phe Ile Thr Gly Phe Val Gln Leu Ser Ile Ser Val Thr Ala Leu 
        755                 760                 765             


Thr Ala Ile Leu Lys Tyr Gly Gln Val Leu Met His Ser His Val Val 
    770                 775                 780                 


Ile Ile Trp Leu Phe Leu Ala Val Tyr Ala Val Ala Thr Ile Met Phe 
785                 790                 795                 800 


Cys Phe Leu Val Ser Val Leu Tyr Ser Lys Ala Lys Leu Ala Ser Ala 
                805                 810                 815     


Cys Gly Gly Ile Ile Tyr Phe Leu Ser Tyr Val Pro Tyr Met Tyr Val 
            820                 825                 830         


Ala Ile Arg Glu Glu Val Ala His Asp Lys Ile Thr Ala Phe Glu Lys 
        835                 840                 845             


Cys Ile Ala Ser Leu Met Ser Thr Thr Ala Phe Gly Leu Gly Ser Lys 
    850                 855                 860                 


Tyr Phe Ala Leu Tyr Glu Val Ala Gly Val Gly Ile Gln Trp His Thr 
865                 870                 875                 880 


Phe Ser Gln Ser Pro Val Glu Gly Asp Asp Phe Asn Leu Leu Leu Ala 
                885                 890                 895     


Val Thr Met Leu Met Val Asp Ala Val Val Tyr Gly Ile Leu Thr Trp 
            900                 905                 910         


Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly Leu Pro Arg Pro Trp 
        915                 920                 925             


Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly Ser Gly Arg Thr Glu 
    930                 935                 940                 


Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr Pro Arg Leu Ser Val 
945                 950                 955                 960 


Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser Arg Arg Phe Glu Glu 
                965                 970                 975     


Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu Pro Leu Val Val Cys 
            980                 985                 990         


Val Asp Lys Leu Thr Lys Val Tyr  Lys Asp Asp Lys Lys  Leu Ala Leu 
        995                 1000                 1005             


Asn Lys  Leu Ser Leu Asn Leu  Tyr Glu Asn Gln Val  Val Ser Phe 
    1010                 1015                 1020             


Leu Gly  His Asn Gly Ala Gly  Lys Thr Thr Thr Met  Ser Ile Leu 
    1025                 1030                 1035             


Thr Gly  Leu Phe Pro Pro Thr  Ser Gly Ser Ala Thr  Ile Tyr Gly 
    1040                 1045                 1050             


His Asp  Ile Arg Thr Glu Met  Asp Glu Ile Arg Lys  Asn Leu Gly 
    1055                 1060                 1065             


Met Cys  Pro Gln His Asn Val  Leu Phe Asp Arg Leu  Thr Val Glu 
    1070                 1075                 1080             


Glu His  Leu Trp Phe Tyr Ser  Arg Leu Lys Ser Met  Ala Gln Glu 
    1085                 1090                 1095             


Glu Ile  Arg Arg Glu Met Asp  Lys Met Ile Glu Asp  Leu Glu Leu 
    1100                 1105                 1110             


Ser Asn  Lys Arg His Ser Leu  Val Gln Thr Leu Ser  Gly Gly Met 
    1115                 1120                 1125             


Lys Arg  Lys Leu Ser Val Ala  Ile Ala Phe Val Gly  Gly Ser Arg 
    1130                 1135                 1140             


Ala Ile  Ile Leu Asp Glu Pro  Thr Ala Gly Val Asp  Pro Tyr Ala 
    1145                 1150                 1155             


Arg Arg  Ala Ile Trp Asp Leu  Ile Leu Lys Tyr Lys  Pro Gly Arg 
    1160                 1165                 1170             


Thr Ile  Leu Leu Ser Thr His  His Met Asp Glu Ala  Asp Leu Leu 
    1175                 1180                 1185             


Gly Asp  Arg Ile Ala Ile Ile  Ser His Gly Lys Leu  Lys Cys Cys 
    1190                 1195                 1200             


Gly Ser  Pro Leu Phe Leu Lys  Gly Thr Tyr Gly Asp  Gly Tyr Arg 
    1205                 1210                 1215             


Leu Thr  Leu Val Lys Arg Pro  Ala Glu Pro Gly Gly  Pro Gln Glu 
    1220                 1225                 1230             


Pro Gly  Leu Ala Ser Ser Pro  Pro Gly Arg Ala Pro  Leu Ser Ser 
    1235                 1240                 1245             


Cys Ser  Glu Leu Gln Val Ser  Gln Phe Ile Arg Lys  His Val Ala 
    1250                 1255                 1260             


Ser Cys  Leu Leu Val Ser Asp  Thr Ser Thr Glu Leu  Ser Tyr Ile 
    1265                 1270                 1275             


Leu Pro  Ser Glu Ala Ala Lys  Lys Gly Ala Phe Glu  Arg Leu Phe 
    1280                 1285                 1290             


Gln His  Leu Glu Arg Ser Leu  Asp Ala Leu His Leu  Ser Ser Phe 
    1295                 1300                 1305             


Gly Leu  Met Asp Thr Thr Leu  Glu Glu Val Phe Leu  Lys Val Ser 
    1310                 1315                 1320             


Glu Glu  Asp Gln Ser Leu Glu  Asn Ser Glu Ala Asp  Val Lys Glu 
    1325                 1330                 1335             


Ser Arg  Lys Asp Val Leu Pro  Gly Ala Glu Gly Pro  Ala Ser Gly 
    1340                 1345                 1350             


Glu Gly  His Ala Gly Asn Leu  Ala Arg Cys Ser Glu  Leu Thr Gln 
    1355                 1360                 1365             


Ser Gln  Ala Ser Leu Gln Ser  Ala Ser Ser Val Gly  Ser Ala Arg 
    1370                 1375                 1380             


Gly Asp  Glu Gly Ala Gly Tyr  Thr Asp Val Tyr Gly  Asp Tyr Arg 
    1385                 1390                 1395             


Pro Leu  Phe Asp Asn Pro Gln  Asp Pro Asp Asn Val  Ser Leu Gln 
    1400                 1405                 1410             


Glu Val  Glu Ala Glu Ala Leu  Ser Arg Val Gly Gln  Gly Ser Arg 
    1415                 1420                 1425             


Lys Leu  Asp Gly Gly Trp Leu  Lys Val Arg Gln Phe  His Gly Leu 
    1430                 1435                 1440             


Leu Val  Lys Arg Phe His Cys  Ala Arg Arg Asn Ser  Lys Ala Leu 
    1445                 1450                 1455             


Phe Ser  Gln Ile Leu Leu Pro  Ala Phe Phe Val Cys  Val Ala Met 
    1460                 1465                 1470             


Thr Val  Ala Leu Ser Val Pro  Glu Ile Gly Asp Leu  Pro Pro Leu 
    1475                 1480                 1485             


Val Leu  Ser Pro Ser Gln Tyr  His Asn Tyr Thr Gln  Pro Arg Gly 
    1490                 1495                 1500             


Asn Phe  Ile Pro Tyr Ala Asn  Glu Glu Arg Arg Glu  Tyr Arg Leu 
    1505                 1510                 1515             


Arg Leu  Ser Pro Asp Ala Ser  Pro Gln Gln Leu Val  Ser Thr Phe 
    1520                 1525                 1530             


Arg Leu  Pro Ser Gly Val Gly  Ala Thr Cys Val Leu  Lys Ser Pro 
    1535                 1540                 1545             


Ala Asn  Gly Ser Leu Gly Pro  Thr Leu Asn Leu Ser  Ser Gly Glu 
    1550                 1555                 1560             


Ser Arg  Leu Leu Ala Ala Arg  Phe Phe Asp Ser Met  Cys Leu Glu 
    1565                 1570                 1575             


Ser Phe  Thr Gln Gly Leu Pro  Leu Ser Asn Phe Val  Pro Pro Pro 
    1580                 1585                 1590             


Pro Ser  Pro Ala Pro Ser Asp  Ser Pro Ala Ser Pro  Asp Glu Asp 
    1595                 1600                 1605             


Leu Gln  Ala Trp Asn Val Ser  Leu Pro Pro Thr Ala  Gly Pro Glu 
    1610                 1615                 1620             


Met Trp  Thr Ser Ala Pro Ser  Leu Pro Arg Leu Val  Arg Glu Pro 
    1625                 1630                 1635             


Val Arg  Cys Thr Cys Ser Ala  Gln Gly Thr Gly Phe  Ser Cys Pro 
    1640                 1645                 1650             


Ser Ser  Val Gly Gly His Pro  Pro Gln Met Arg Val  Val Thr Gly 
    1655                 1660                 1665             


Asp Ile  Leu Thr Asp Ile Thr  Gly His Asn Val Ser  Glu Tyr Leu 
    1670                 1675                 1680             


Leu Phe  Thr Ser Asp Arg Phe  Arg Leu His Arg Tyr  Gly Ala Ile 
    1685                 1690                 1695             


Thr Phe  Gly Asn Val Leu Lys  Ser Ile Pro Ala Ser  Phe Gly Thr 
    1700                 1705                 1710             


Arg Ala  Pro Pro Met Val Arg  Lys Ile Ala Val Arg  Arg Ala Ala 
    1715                 1720                 1725             


Gln Val  Phe Tyr Asn Asn Lys  Gly Tyr His Ser Met  Pro Thr Tyr 
    1730                 1735                 1740             


Leu Asn  Ser Leu Asn Asn Ala  Ile Leu Arg Ala Asn  Leu Pro Lys 
    1745                 1750                 1755             


Ser Lys  Gly Asn Pro Ala Ala  Tyr Gly Ile Thr Val  Thr Asn His 
    1760                 1765                 1770             


Pro Met  Asn Lys Thr Ser Ala  Ser Leu Ser Leu Asp  Tyr Leu Leu 
    1775                 1780                 1785             


Gln Gly  Thr Asp Val Val Ile  Ala Ile Phe Ile Ile  Val Ala Met 
    1790                 1795                 1800             


Ser Phe  Val Pro Ala Ser Phe  Val Val Phe Leu Val  Ala Glu Lys 
    1805                 1810                 1815             


Ser Thr  Lys Ala Lys His Leu  Gln Phe Val Ser Gly  Cys Asn Pro 
    1820                 1825                 1830             


Ile Ile  Tyr Trp Leu Ala Asn  Tyr Val Trp Asp Met  Leu Asn Tyr 
    1835                 1840                 1845             


Leu Val  Pro Ala Thr Cys Cys  Val Ile Ile Leu Phe  Val Phe Asp 
    1850                 1855                 1860             


Leu Pro  Ala Tyr Thr Ser Pro  Thr Asn Phe Pro Ala  Val Leu Ser 
    1865                 1870                 1875             


Leu Phe  Leu Leu Tyr Gly Trp  Ser Ile Thr Pro Ile  Met Tyr Pro 
    1880                 1885                 1890             


Ala Ser  Phe Trp Phe Glu Val  Pro Ser Ser Ala Tyr  Val Phe Leu 
    1895                 1900                 1905             


Ile Val  Ile Asn Leu Phe Ile  Gly Ile Thr Ala Thr  Val Ala Thr 
    1910                 1915                 1920             


Phe Leu  Leu Gln Leu Phe Glu  His Asp Lys Asp Leu  Lys Val Val 
    1925                 1930                 1935             


Asn Ser  Tyr Leu Lys Ser Cys  Phe Leu Ile Phe Pro  Asn Tyr Asn 
    1940                 1945                 1950             


Leu Gly  His Gly Leu Met Glu  Met Ala Tyr Asn Glu  Tyr Ile Asn 
    1955                 1960                 1965             


Glu Tyr  Tyr Ala Lys Ile Gly  Gln Phe Asp Lys Met  Lys Ser Pro 
    1970                 1975                 1980             


Phe Glu  Trp Asp Ile Val Thr  Arg Gly Leu Val Ala  Met Ala Val 
    1985                 1990                 1995             


Glu Gly  Val Val Gly Phe Leu  Leu Thr Ile Met Cys  Gln Tyr Asn 
    2000                 2005                 2010             


Phe Leu  Arg Arg Pro Gln Arg  Met Pro Val Ser Thr  Lys Pro Val 
    2015                 2020                 2025             


Glu Asp  Asp Val Asp Val Ala  Ser Glu Arg Gln Arg  Val Leu Arg 
    2030                 2035                 2040             


Gly Asp  Ala Asp Asn Asp Met  Val Lys Ile Glu Asn  Leu Thr Lys 
    2045                 2050                 2055             


Val Tyr  Lys Ser Arg Lys Ile  Gly Arg Ile Leu Ala  Val Asp Arg 
    2060                 2065                 2070             


Leu Cys  Leu Gly Val Arg Pro  Gly Glu Cys Phe Gly  Leu Leu Gly 
    2075                 2080                 2085             


Val Asn  Gly Ala Gly Lys Thr  Ser Thr Phe Lys Met  Leu Thr Gly 
    2090                 2095                 2100             


Asp Glu  Ser Thr Thr Gly Gly  Glu Ala Phe Val Asn  Gly His Ser 
    2105                 2110                 2115             


Val Leu  Lys Glu Leu Leu Gln  Val Gln Gln Ser Leu  Gly Tyr Cys 
    2120                 2125                 2130             


Pro Gln  Cys Asp Ala Leu Phe  Asp Glu Leu Thr Ala  Arg Glu His 
    2135                 2140                 2145             


Leu Gln  Leu Tyr Thr Arg Leu  Arg Gly Ile Ser Trp  Lys Asp Glu 
    2150                 2155                 2160             


Ala Arg  Val Val Lys Trp Ala  Leu Glu Lys Leu Glu  Leu Thr Lys 
    2165                 2170                 2175             


Tyr Ala  Asp Lys Pro Ala Gly  Thr Tyr Ser Gly Gly  Asn Lys Arg 
    2180                 2185                 2190             


Lys Leu  Ser Thr Ala Ile Ala  Leu Ile Gly Tyr Pro  Ala Phe Ile 
    2195                 2200                 2205             


Phe Leu  Asp Glu Pro Thr Thr  Gly Met Asp Pro Lys  Ala Arg Arg 
    2210                 2215                 2220             


Phe Leu  Trp Asn Leu Ile Leu  Asp Leu Ile Lys Thr  Gly Arg Ser 
    2225                 2230                 2235             


Val Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    2240                 2245                 2250             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Arg Leu Arg  Cys Leu Gly 
    2255                 2260                 2265             


Ser Ile  Gln His Leu Lys Asn  Arg Phe Gly Asp Gly  Tyr Met Ile 
    2270                 2275                 2280             


Thr Val  Arg Thr Lys Ser Ser  Gln Ser Val Lys Asp  Val Val Arg 
    2285                 2290                 2295             


Phe Phe  Asn Arg Asn Phe Pro  Glu Ala Met Leu Lys  Glu Arg His 
    2300                 2305                 2310             


His Thr  Lys Val Gln Tyr Gln  Leu Lys Ser Glu His  Ile Ser Leu 
    2315                 2320                 2325             


Ala Gln  Val Phe Ser Lys Met  Glu Gln Val Ser Gly  Val Leu Gly 
    2330                 2335                 2340             


Ile Glu  Asp Tyr Ser Val Ser  Gln Thr Thr Leu Asp  Asn Val Phe 
    2345                 2350                 2355             


Val Asn  Phe Ala Lys Lys Gln  Ser Asp Asn Leu Glu  Gln Gln Glu 
    2360                 2365                 2370             


Thr Glu  Pro Pro Ser Ala Leu  Gln Ser Pro Leu Gly  Cys Leu Leu 
    2375                 2380                 2385             


Ser Leu  Leu Arg Pro Arg Ser  Ala Pro Thr Glu Leu  Arg Ala Leu 
    2390                 2395                 2400             


Val Ala  Asp Glu Pro Glu Asp  Leu Asp Thr Glu Asp  Glu Gly Leu 
    2405                 2410                 2415             


Ile Ser  Phe Glu Glu Glu Arg  Ala Gln Leu Ser Phe  Asn Thr Asp 
    2420                 2425                 2430             


Thr Leu  Cys 
    2435     


<210>  37
<211>  1704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA3__Homo_sapiens__NP_001080

<400>  37

Met Ala Val Leu Arg Gln Leu Ala Leu Leu Leu Trp Lys Asn Tyr Thr 
1               5                   10                  15      


Leu Gln Lys Arg Lys Val Leu Val Thr Val Leu Glu Leu Phe Leu Pro 
            20                  25                  30          


Leu Leu Phe Ser Gly Ile Leu Ile Trp Leu Arg Leu Lys Ile Gln Ser 
        35                  40                  45              


Glu Asn Val Pro Asn Ala Thr Ile Tyr Pro Gly Gln Ser Ile Gln Glu 
    50                  55                  60                  


Leu Pro Leu Phe Phe Thr Phe Pro Pro Pro Gly Asp Thr Trp Glu Leu 
65                  70                  75                  80  


Ala Tyr Ile Pro Ser His Ser Asp Ala Ala Lys Thr Val Thr Glu Thr 
                85                  90                  95      


Val Arg Arg Ala Leu Val Ile Asn Met Arg Val Arg Gly Phe Pro Ser 
            100                 105                 110         


Glu Lys Asp Phe Glu Asp Tyr Ile Arg Tyr Asp Asn Cys Ser Ser Ser 
        115                 120                 125             


Val Leu Ala Ala Val Val Phe Glu His Pro Phe Asn His Ser Lys Glu 
    130                 135                 140                 


Pro Leu Pro Leu Ala Val Lys Tyr His Leu Arg Phe Ser Tyr Thr Arg 
145                 150                 155                 160 


Arg Asn Tyr Met Trp Thr Gln Thr Gly Ser Phe Phe Leu Lys Glu Thr 
                165                 170                 175     


Glu Gly Trp His Thr Thr Ser Leu Phe Pro Leu Phe Pro Asn Pro Gly 
            180                 185                 190         


Pro Arg Glu Pro Thr Ser Pro Asp Gly Gly Glu Pro Gly Tyr Ile Arg 
        195                 200                 205             


Glu Gly Phe Leu Ala Val Gln His Ala Val Asp Arg Ala Ile Met Glu 
    210                 215                 220                 


Tyr His Ala Asp Ala Ala Thr Arg Gln Leu Phe Gln Arg Leu Thr Val 
225                 230                 235                 240 


Thr Ile Lys Arg Phe Pro Tyr Pro Pro Phe Ile Ala Asp Pro Phe Leu 
                245                 250                 255     


Val Ala Ile Gln Tyr Gln Leu Pro Leu Leu Leu Leu Leu Ser Phe Thr 
            260                 265                 270         


Tyr Thr Ala Leu Thr Ile Ala Arg Ala Val Val Gln Glu Lys Glu Arg 
        275                 280                 285             


Arg Leu Lys Glu Tyr Met Arg Met Met Gly Leu Ser Ser Trp Leu His 
    290                 295                 300                 


Trp Ser Ala Trp Phe Leu Leu Phe Phe Leu Phe Leu Leu Ile Ala Ala 
305                 310                 315                 320 


Ser Phe Met Thr Leu Leu Phe Cys Val Lys Val Lys Pro Asn Val Ala 
                325                 330                 335     


Val Leu Ser Arg Ser Asp Pro Ser Leu Val Leu Ala Phe Leu Leu Cys 
            340                 345                 350         


Phe Ala Ile Ser Thr Ile Ser Phe Ser Phe Met Val Ser Thr Phe Phe 
        355                 360                 365             


Ser Lys Ala Asn Met Ala Ala Ala Phe Gly Gly Phe Leu Tyr Phe Phe 
    370                 375                 380                 


Thr Tyr Ile Pro Tyr Phe Phe Val Ala Pro Arg Tyr Asn Trp Met Thr 
385                 390                 395                 400 


Leu Ser Gln Lys Leu Cys Ser Cys Leu Leu Ser Asn Val Ala Met Ala 
                405                 410                 415     


Met Gly Ala Gln Leu Ile Gly Lys Phe Glu Ala Lys Gly Met Gly Ile 
            420                 425                 430         


Gln Trp Arg Asp Leu Leu Ser Pro Val Asn Val Asp Asp Asp Phe Cys 
        435                 440                 445             


Phe Gly Gln Val Leu Gly Met Leu Leu Leu Asp Ser Val Leu Tyr Gly 
    450                 455                 460                 


Leu Val Thr Trp Tyr Met Glu Ala Val Phe Pro Gly Gln Phe Gly Val 
465                 470                 475                 480 


Pro Gln Pro Trp Tyr Phe Phe Ile Met Pro Ser Tyr Trp Cys Gly Lys 
                485                 490                 495     


Pro Arg Ala Val Ala Gly Lys Glu Glu Glu Asp Ser Asp Pro Glu Lys 
            500                 505                 510         


Ala Leu Arg Asn Glu Tyr Phe Glu Ala Glu Pro Glu Asp Leu Val Ala 
        515                 520                 525             


Gly Ile Lys Ile Lys His Leu Ser Lys Val Phe Arg Val Gly Asn Lys 
    530                 535                 540                 


Asp Arg Ala Ala Val Arg Asp Leu Asn Leu Asn Leu Tyr Glu Gly Gln 
545                 550                 555                 560 


Ile Thr Val Leu Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu 
                565                 570                 575     


Ser Met Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Arg Ala Tyr Ile 
            580                 585                 590         


Ser Gly Tyr Glu Ile Ser Gln Asp Met Val Gln Ile Arg Lys Ser Leu 
        595                 600                 605             


Gly Leu Cys Pro Gln His Asp Ile Leu Phe Asp Asn Leu Thr Val Ala 
    610                 615                 620                 


Glu His Leu Tyr Phe Tyr Ala Gln Leu Lys Gly Leu Ser Arg Gln Lys 
625                 630                 635                 640 


Cys Pro Glu Glu Val Lys Gln Met Leu His Ile Ile Gly Leu Glu Asp 
                645                 650                 655     


Lys Trp Asn Ser Arg Ser Arg Phe Leu Ser Gly Gly Met Arg Arg Lys 
            660                 665                 670         


Leu Ser Ile Gly Ile Ala Leu Ile Ala Gly Ser Lys Val Leu Ile Leu 
        675                 680                 685             


Asp Glu Pro Thr Ser Gly Met Asp Ala Ile Ser Arg Arg Ala Ile Trp 
    690                 695                 700                 


Asp Leu Leu Gln Arg Gln Lys Ser Asp Arg Thr Ile Val Leu Thr Thr 
705                 710                 715                 720 


His Phe Met Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Met 
                725                 730                 735     


Ala Lys Gly Glu Leu Gln Cys Cys Gly Ser Ser Leu Phe Leu Lys Gln 
            740                 745                 750         


Lys Tyr Gly Ala Gly Tyr His Met Thr Leu Val Lys Glu Pro His Cys 
        755                 760                 765             


Asn Pro Glu Asp Ile Ser Gln Leu Val His His His Val Pro Asn Ala 
    770                 775                 780                 


Thr Leu Glu Ser Ser Ala Gly Ala Glu Leu Ser Phe Ile Leu Pro Arg 
785                 790                 795                 800 


Glu Ser Thr His Arg Phe Glu Gly Leu Phe Ala Lys Leu Glu Lys Lys 
                805                 810                 815     


Gln Lys Glu Leu Gly Ile Ala Ser Phe Gly Ala Ser Ile Thr Thr Met 
            820                 825                 830         


Glu Glu Val Phe Leu Arg Val Gly Lys Leu Val Asp Ser Ser Met Asp 
        835                 840                 845             


Ile Gln Ala Ile Gln Leu Pro Ala Leu Gln Tyr Gln His Glu Arg Arg 
    850                 855                 860                 


Ala Ser Asp Trp Ala Val Asp Ser Asn Leu Cys Gly Ala Met Asp Pro 
865                 870                 875                 880 


Ser Asp Gly Ile Gly Ala Leu Ile Glu Glu Glu Arg Thr Ala Val Lys 
                885                 890                 895     


Leu Asn Thr Gly Leu Ala Leu His Cys Gln Gln Phe Trp Ala Met Phe 
            900                 905                 910         


Leu Lys Lys Ala Ala Tyr Ser Trp Arg Glu Trp Lys Met Val Ala Ala 
        915                 920                 925             


Gln Val Leu Val Pro Leu Thr Cys Val Thr Leu Ala Leu Leu Ala Ile 
    930                 935                 940                 


Asn Tyr Ser Ser Glu Leu Phe Asp Asp Pro Met Leu Arg Leu Thr Leu 
945                 950                 955                 960 


Gly Glu Tyr Gly Arg Thr Val Val Pro Phe Ser Val Pro Gly Thr Ser 
                965                 970                 975     


Gln Leu Gly Gln Gln Leu Ser Glu His Leu Lys Asp Ala Leu Gln Ala 
            980                 985                 990         


Glu Gly Gln Glu Pro Arg Glu Val  Leu Gly Asp Leu Glu  Glu Phe Leu 
        995                 1000                 1005             


Ile Phe  Arg Ala Ser Val Glu  Gly Gly Gly Phe Asn  Glu Arg Cys 
    1010                 1015                 1020             


Leu Val  Ala Ala Ser Phe Arg  Asp Val Gly Glu Arg  Thr Val Val 
    1025                 1030                 1035             


Asn Ala  Leu Phe Asn Asn Gln  Ala Tyr His Ser Pro  Ala Thr Ala 
    1040                 1045                 1050             


Leu Ala  Val Val Asp Asn Leu  Leu Phe Lys Leu Leu  Cys Gly Pro 
    1055                 1060                 1065             


His Ala  Ser Ile Val Val Ser  Asn Phe Pro Gln Pro  Arg Ser Ala 
    1070                 1075                 1080             


Leu Gln  Ala Ala Lys Asp Gln  Phe Asn Glu Gly Arg  Lys Gly Phe 
    1085                 1090                 1095             


Asp Ile  Ala Leu Asn Leu Leu  Phe Ala Met Ala Phe  Leu Ala Ser 
    1100                 1105                 1110             


Thr Phe  Ser Ile Leu Ala Val  Ser Glu Arg Ala Val  Gln Ala Lys 
    1115                 1120                 1125             


His Val  Gln Phe Val Ser Gly  Val His Val Ala Ser  Phe Trp Leu 
    1130                 1135                 1140             


Ser Ala  Leu Leu Trp Asp Leu  Ile Ser Phe Leu Ile  Pro Ser Leu 
    1145                 1150                 1155             


Leu Leu  Leu Val Val Phe Lys  Ala Phe Asp Val Arg  Ala Phe Thr 
    1160                 1165                 1170             


Arg Asp  Gly His Met Ala Asp  Thr Leu Leu Leu Leu  Leu Leu Tyr 
    1175                 1180                 1185             


Gly Trp  Ala Ile Ile Pro Leu  Met Tyr Leu Met Asn  Phe Phe Phe 
    1190                 1195                 1200             


Leu Gly  Ala Ala Thr Ala Tyr  Thr Arg Leu Thr Ile  Phe Asn Ile 
    1205                 1210                 1215             


Leu Ser  Gly Ile Ala Thr Phe  Leu Met Val Thr Ile  Met Arg Ile 
    1220                 1225                 1230             


Pro Ala  Val Lys Leu Glu Glu  Leu Ser Lys Thr Leu  Asp His Val 
    1235                 1240                 1245             


Phe Leu  Val Leu Pro Asn His  Cys Leu Gly Met Ala  Val Ser Ser 
    1250                 1255                 1260             


Phe Tyr  Glu Asn Tyr Glu Thr  Arg Arg Tyr Cys Thr  Ser Ser Glu 
    1265                 1270                 1275             


Val Ala  Ala His Tyr Cys Lys  Lys Tyr Asn Ile Gln  Tyr Gln Glu 
    1280                 1285                 1290             


Asn Phe  Tyr Ala Trp Ser Ala  Pro Gly Val Gly Arg  Phe Val Ala 
    1295                 1300                 1305             


Ser Met  Ala Ala Ser Gly Cys  Ala Tyr Leu Ile Leu  Leu Phe Leu 
    1310                 1315                 1320             


Ile Glu  Thr Asn Leu Leu Gln  Arg Leu Arg Gly Ile  Leu Cys Ala 
    1325                 1330                 1335             


Leu Arg  Arg Arg Arg Thr Leu  Thr Glu Leu Tyr Thr  Arg Met Pro 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Gln Asp  Val Ala Asp Glu Arg  Thr Arg Ile 
    1355                 1360                 1365             


Leu Ala  Pro Ser Pro Asp Ser  Leu Leu His Thr Pro  Leu Ile Ile 
    1370                 1375                 1380             


Lys Glu  Leu Ser Lys Val Tyr  Glu Gln Arg Val Pro  Leu Leu Ala 
    1385                 1390                 1395             


Val Asp  Arg Leu Ser Leu Ala  Val Gln Lys Gly Glu  Cys Phe Gly 
    1400                 1405                 1410             


Leu Leu  Gly Phe Asn Gly Ala  Gly Lys Thr Thr Thr  Phe Lys Met 
    1415                 1420                 1425             


Leu Thr  Gly Glu Glu Ser Leu  Thr Ser Gly Asp Ala  Phe Val Gly 
    1430                 1435                 1440             


Gly His  Arg Ile Ser Ser Asp  Val Gly Lys Val Arg  Gln Arg Ile 
    1445                 1450                 1455             


Gly Tyr  Cys Pro Gln Phe Asp  Ala Leu Leu Asp His  Met Thr Gly 
    1460                 1465                 1470             


Arg Glu  Met Leu Val Met Tyr  Ala Arg Leu Arg Gly  Ile Pro Glu 
    1475                 1480                 1485             


Arg His  Ile Gly Ala Cys Val  Glu Asn Thr Leu Arg  Gly Leu Leu 
    1490                 1495                 1500             


Leu Glu  Pro His Ala Asn Lys  Leu Val Arg Thr Tyr  Ser Gly Gly 
    1505                 1510                 1515             


Asn Lys  Arg Lys Leu Ser Thr  Gly Ile Ala Leu Ile  Gly Glu Pro 
    1520                 1525                 1530             


Ala Val  Ile Phe Leu Asp Glu  Pro Ser Thr Gly Met  Asp Pro Val 
    1535                 1540                 1545             


Ala Arg  Arg Leu Leu Trp Asp  Thr Val Ala Arg Ala  Arg Glu Ser 
    1550                 1555                 1560             


Gly Lys  Ala Ile Ile Ile Thr  Ser His Ser Met Glu  Glu Cys Glu 
    1565                 1570                 1575             


Ala Leu  Cys Thr Arg Leu Ala  Ile Met Val Gln Gly  Gln Phe Lys 
    1580                 1585                 1590             


Cys Leu  Gly Ser Pro Gln His  Leu Lys Ser Lys Phe  Gly Ser Gly 
    1595                 1600                 1605             


Tyr Ser  Leu Arg Ala Lys Val  Gln Ser Glu Gly Gln  Gln Glu Ala 
    1610                 1615                 1620             


Leu Glu  Glu Phe Lys Ala Phe  Val Asp Leu Thr Phe  Pro Gly Ser 
    1625                 1630                 1635             


Val Leu  Glu Asp Glu His Gln  Gly Met Val His Tyr  His Leu Pro 
    1640                 1645                 1650             


Gly Arg  Asp Leu Ser Trp Ala  Lys Val Phe Gly Ile  Leu Glu Lys 
    1655                 1660                 1665             


Ala Lys  Glu Lys Tyr Gly Val  Asp Asp Tyr Ser Val  Ser Gln Ile 
    1670                 1675                 1680             


Ser Leu  Glu Gln Val Phe Leu  Ser Phe Ala His Leu  Gln Pro Pro 
    1685                 1690                 1695             


Thr Ala  Glu Glu Gly Arg 
    1700                 


<210>  38
<211>  1642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA5__Homo_sapiens__NP_758424

<400>  38

Met Ser Thr Ala Ile Arg Glu Val Gly Val Trp Arg Gln Thr Arg Thr 
1               5                   10                  15      


Leu Leu Leu Lys Asn Tyr Leu Ile Lys Cys Arg Thr Lys Lys Ser Ser 
            20                  25                  30          


Val Gln Glu Ile Leu Phe Pro Leu Phe Phe Leu Phe Trp Leu Ile Leu 
        35                  40                  45              


Ile Ser Met Met His Pro Asn Lys Lys Tyr Glu Glu Val Pro Asn Ile 
    50                  55                  60                  


Glu Leu Asn Pro Met Asp Lys Phe Thr Leu Ser Asn Leu Ile Leu Gly 
65                  70                  75                  80  


Tyr Thr Pro Val Thr Asn Ile Thr Ser Ser Ile Met Gln Lys Val Ser 
                85                  90                  95      


Thr Asp His Leu Pro Asp Val Ile Ile Thr Glu Glu Tyr Thr Asn Glu 
            100                 105                 110         


Lys Glu Met Leu Thr Ser Ser Leu Ser Lys Pro Ser Asn Phe Val Gly 
        115                 120                 125             


Val Val Phe Lys Asp Ser Met Ser Tyr Glu Leu Arg Phe Phe Pro Asp 
    130                 135                 140                 


Met Ile Pro Val Ser Ser Ile Tyr Met Asp Ser Arg Ala Gly Cys Ser 
145                 150                 155                 160 


Lys Ser Cys Glu Ala Ala Gln Tyr Trp Ser Ser Gly Phe Thr Val Leu 
                165                 170                 175     


Gln Ala Ser Ile Asp Ala Ala Ile Ile Gln Leu Lys Thr Asn Val Ser 
            180                 185                 190         


Leu Trp Lys Glu Leu Glu Ser Thr Lys Ala Val Ile Met Gly Glu Thr 
        195                 200                 205             


Ala Val Val Glu Ile Asp Thr Phe Pro Arg Gly Val Ile Leu Ile Tyr 
    210                 215                 220                 


Leu Val Ile Ala Phe Ser Pro Phe Gly Tyr Phe Leu Ala Ile His Ile 
225                 230                 235                 240 


Val Ala Glu Lys Glu Lys Lys Ile Lys Glu Phe Leu Lys Ile Met Gly 
                245                 250                 255     


Leu His Asp Thr Ala Phe Trp Leu Ser Trp Val Leu Leu Tyr Thr Ser 
            260                 265                 270         


Leu Ile Phe Leu Met Ser Leu Leu Met Ala Val Ile Ala Thr Ala Ser 
        275                 280                 285             


Leu Leu Phe Pro Gln Ser Ser Ser Ile Val Ile Phe Leu Leu Phe Phe 
    290                 295                 300                 


Leu Tyr Gly Leu Ser Ser Val Phe Phe Ala Leu Met Leu Thr Pro Leu 
305                 310                 315                 320 


Phe Lys Lys Ser Lys His Val Gly Ile Val Glu Phe Phe Val Thr Val 
                325                 330                 335     


Ala Phe Gly Phe Ile Gly Leu Met Ile Ile Leu Ile Glu Ser Phe Pro 
            340                 345                 350         


Lys Ser Leu Val Trp Leu Phe Ser Pro Phe Cys His Cys Thr Phe Val 
        355                 360                 365             


Ile Gly Ile Ala Gln Val Met His Leu Glu Asp Phe Asn Glu Gly Ala 
    370                 375                 380                 


Ser Phe Ser Asn Leu Thr Ala Gly Pro Tyr Pro Leu Ile Ile Thr Ile 
385                 390                 395                 400 


Ile Met Leu Thr Leu Asn Ser Ile Phe Tyr Val Leu Leu Ala Val Tyr 
                405                 410                 415     


Leu Asp Gln Val Ile Pro Gly Glu Phe Gly Leu Arg Arg Ser Ser Leu 
            420                 425                 430         


Tyr Phe Leu Lys Pro Ser Tyr Trp Ser Lys Ser Lys Arg Asn Tyr Glu 
        435                 440                 445             


Glu Leu Ser Glu Gly Asn Val Asn Gly Asn Ile Ser Phe Ser Glu Ile 
    450                 455                 460                 


Ile Glu Pro Val Ser Ser Glu Phe Val Gly Lys Glu Ala Ile Arg Ile 
465                 470                 475                 480 


Ser Gly Ile Gln Lys Thr Tyr Arg Lys Lys Gly Glu Asn Val Glu Ala 
                485                 490                 495     


Leu Arg Asn Leu Ser Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Leu 
            500                 505                 510         


Leu Gly His Ser Gly Thr Gly Lys Ser Thr Leu Met Asn Ile Leu Cys 
        515                 520                 525             


Gly Leu Cys Pro Pro Ser Asp Gly Phe Ala Ser Ile Tyr Gly His Arg 
    530                 535                 540                 


Val Ser Glu Ile Asp Glu Met Phe Glu Ala Arg Lys Met Ile Gly Ile 
545                 550                 555                 560 


Cys Pro Gln Leu Asp Ile His Phe Asp Val Leu Thr Val Glu Glu Asn 
                565                 570                 575     


Leu Ser Ile Leu Ala Ser Ile Lys Gly Ile Pro Ala Asn Asn Ile Ile 
            580                 585                 590         


Gln Glu Val Gln Lys Val Leu Leu Asp Leu Asp Met Gln Thr Ile Lys 
        595                 600                 605             


Asp Asn Gln Ala Lys Lys Leu Ser Gly Gly Gln Lys Arg Lys Leu Ser 
    610                 615                 620                 


Leu Gly Ile Ala Val Leu Gly Asn Pro Lys Ile Leu Leu Leu Asp Glu 
625                 630                 635                 640 


Pro Thr Ala Gly Met Asp Pro Cys Ser Arg His Ile Val Trp Asn Leu 
                645                 650                 655     


Leu Lys Tyr Arg Lys Ala Asn Arg Val Thr Val Phe Ser Thr His Phe 
            660                 665                 670         


Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Ala Val Ile Ser Gln 
        675                 680                 685             


Gly Met Leu Lys Cys Val Gly Ser Ser Met Phe Leu Lys Ser Lys Trp 
    690                 695                 700                 


Gly Ile Gly Tyr Arg Leu Ser Met Tyr Ile Asp Lys Tyr Cys Ala Thr 
705                 710                 715                 720 


Glu Ser Leu Ser Ser Leu Val Lys Gln His Ile Pro Gly Ala Thr Leu 
                725                 730                 735     


Leu Gln Gln Asn Asp Gln Gln Leu Val Tyr Ser Leu Pro Phe Lys Asp 
            740                 745                 750         


Met Asp Lys Phe Ser Gly Leu Phe Ser Ala Leu Asp Ser His Ser Asn 
        755                 760                 765             


Leu Gly Val Ile Ser Tyr Gly Val Ser Met Thr Thr Leu Glu Asp Val 
    770                 775                 780                 


Phe Leu Lys Leu Glu Val Glu Ala Glu Ile Asp Gln Ala Asp Tyr Ser 
785                 790                 795                 800 


Val Phe Thr Gln Gln Pro Leu Glu Glu Glu Met Asp Ser Lys Ser Phe 
                805                 810                 815     


Asp Glu Met Glu Gln Ser Leu Leu Ile Leu Ser Glu Thr Lys Ala Ala 
            820                 825                 830         


Leu Val Ser Thr Met Ser Leu Trp Lys Gln Gln Met Tyr Thr Ile Ala 
        835                 840                 845             


Lys Phe His Phe Phe Thr Leu Lys Arg Glu Ser Lys Ser Val Arg Ser 
    850                 855                 860                 


Val Leu Leu Leu Leu Leu Ile Phe Phe Thr Val Gln Ile Phe Met Phe 
865                 870                 875                 880 


Leu Val His His Ser Phe Lys Asn Ala Val Val Pro Ile Lys Leu Val 
                885                 890                 895     


Pro Asp Leu Tyr Phe Leu Lys Pro Gly Asp Lys Pro His Lys Tyr Lys 
            900                 905                 910         


Thr Ser Leu Leu Leu Gln Asn Ser Ala Asp Ser Asp Ile Ser Asp Leu 
        915                 920                 925             


Ile Ser Phe Phe Thr Ser Gln Asn Ile Met Val Thr Met Ile Asn Asp 
    930                 935                 940                 


Ser Asp Tyr Val Ser Val Ala Pro His Ser Ala Ala Leu Asn Val Met 
945                 950                 955                 960 


His Ser Glu Lys Asp Tyr Val Phe Ala Ala Val Phe Asn Ser Thr Met 
                965                 970                 975     


Val Tyr Ser Leu Pro Ile Leu Val Asn Ile Ile Ser Asn Tyr Tyr Leu 
            980                 985                 990         


Tyr His Leu Asn Val Thr Glu Thr  Ile Gln Ile Trp Ser  Thr Pro Phe 
        995                 1000                 1005             


Phe Gln  Glu Ile Thr Asp Ile  Val Phe Lys Ile Glu  Leu Tyr Phe 
    1010                 1015                 1020             


Gln Ala  Ala Leu Leu Gly Ile  Ile Val Thr Ala Met  Pro Pro Tyr 
    1025                 1030                 1035             


Phe Ala  Met Glu Asn Ala Glu  Asn His Lys Ile Lys  Ala Tyr Thr 
    1040                 1045                 1050             


Gln Leu  Lys Leu Ser Gly Leu  Leu Pro Ser Ala Tyr  Trp Ile Gly 
    1055                 1060                 1065             


Gln Ala  Val Val Asp Ile Pro  Leu Phe Phe Ile Ile  Leu Ile Leu 
    1070                 1075                 1080             


Met Leu  Gly Ser Leu Leu Ala  Phe His Tyr Gly Leu  Tyr Phe Tyr 
    1085                 1090                 1095             


Thr Val  Lys Phe Leu Ala Val  Val Phe Cys Leu Ile  Gly Tyr Val 
    1100                 1105                 1110             


Pro Ser  Val Ile Leu Phe Thr  Tyr Ile Ala Ser Phe  Thr Phe Lys 
    1115                 1120                 1125             


Lys Ile  Leu Asn Thr Lys Glu  Phe Trp Ser Phe Ile  Tyr Ser Val 
    1130                 1135                 1140             


Ala Ala  Leu Ala Cys Ile Ala  Ile Thr Glu Ile Thr  Phe Phe Met 
    1145                 1150                 1155             


Gly Tyr  Thr Ile Ala Thr Ile  Leu His Tyr Ala Phe  Cys Ile Ile 
    1160                 1165                 1170             


Ile Pro  Ile Tyr Pro Leu Leu  Gly Cys Leu Ile Ser  Phe Ile Lys 
    1175                 1180                 1185             


Ile Ser  Trp Lys Asn Val Arg  Lys Asn Val Asp Thr  Tyr Asn Pro 
    1190                 1195                 1200             


Trp Asp  Arg Leu Ser Val Ala  Val Ile Ser Pro Tyr  Leu Gln Cys 
    1205                 1210                 1215             


Val Leu  Trp Ile Phe Leu Leu  Gln Tyr Tyr Glu Lys  Lys Tyr Gly 
    1220                 1225                 1230             


Gly Arg  Ser Ile Arg Lys Asp  Pro Phe Phe Arg Asn  Leu Ser Thr 
    1235                 1240                 1245             


Lys Ser  Lys Asn Arg Lys Leu  Pro Glu Pro Pro Asp  Asn Glu Asp 
    1250                 1255                 1260             


Glu Asp  Glu Asp Val Lys Ala  Glu Arg Leu Lys Val  Lys Glu Leu 
    1265                 1270                 1275             


Met Gly  Cys Gln Cys Cys Glu  Glu Lys Pro Ser Ile  Met Val Ser 
    1280                 1285                 1290             


Asn Leu  His Lys Glu Tyr Asp  Asp Lys Lys Asp Phe  Leu Leu Ser 
    1295                 1300                 1305             


Arg Lys  Val Lys Lys Val Ala  Thr Lys Tyr Ile Ser  Phe Cys Val 
    1310                 1315                 1320             


Lys Lys  Gly Glu Ile Leu Gly  Leu Leu Gly Pro Asn  Gly Ala Gly 
    1325                 1330                 1335             


Lys Ser  Thr Ile Ile Asn Ile  Leu Val Gly Asp Ile  Glu Pro Thr 
    1340                 1345                 1350             


Ser Gly  Gln Val Phe Leu Gly  Asp Tyr Ser Ser Glu  Thr Ser Glu 
    1355                 1360                 1365             


Asp Asp  Asp Ser Leu Lys Cys  Met Gly Tyr Cys Pro  Gln Ile Asn 
    1370                 1375                 1380             


Pro Leu  Trp Pro Asp Thr Thr  Leu Gln Glu His Phe  Glu Ile Tyr 
    1385                 1390                 1395             


Gly Ala  Val Lys Gly Met Ser  Ala Ser Asp Met Lys  Glu Val Ile 
    1400                 1405                 1410             


Ser Arg  Ile Thr His Ala Leu  Asp Leu Lys Glu His  Leu Gln Lys 
    1415                 1420                 1425             


Thr Val  Lys Lys Leu Pro Ala  Gly Ile Lys Arg Lys  Leu Cys Phe 
    1430                 1435                 1440             


Ala Leu  Ser Met Leu Gly Asn  Pro Gln Ile Thr Leu  Leu Asp Glu 
    1445                 1450                 1455             


Pro Ser  Thr Gly Met Asp Pro  Lys Ala Lys Gln His  Met Trp Arg 
    1460                 1465                 1470             


Ala Ile  Arg Thr Ala Phe Lys  Asn Arg Lys Arg Ala  Ala Ile Leu 
    1475                 1480                 1485             


Thr Thr  His Tyr Met Glu Glu  Ala Glu Ala Val Cys  Asp Arg Val 
    1490                 1495                 1500             


Ala Ile  Met Val Ser Gly Gln  Leu Arg Cys Ile Gly  Thr Val Gln 
    1505                 1510                 1515             


His Leu  Lys Ser Lys Phe Gly  Lys Gly Tyr Phe Leu  Glu Ile Lys 
    1520                 1525                 1530             


Leu Lys  Asp Trp Ile Glu Asn  Leu Glu Val Asp Arg  Leu Gln Arg 
    1535                 1540                 1545             


Glu Ile  Gln Tyr Ile Phe Pro  Asn Ala Ser Arg Gln  Glu Ser Phe 
    1550                 1555                 1560             


Ser Ser  Ile Leu Ala Tyr Lys  Ile Pro Lys Glu Asp  Val Gln Ser 
    1565                 1570                 1575             


Leu Ser  Gln Ser Phe Phe Lys  Leu Glu Glu Ala Lys  His Ala Phe 
    1580                 1585                 1590             


Ala Ile  Glu Glu Tyr Ser Phe  Ser Gln Ala Thr Leu  Glu Gln Val 
    1595                 1600                 1605             


Phe Val  Glu Leu Thr Lys Glu  Gln Glu Glu Glu Asp  Asn Ser Cys 
    1610                 1615                 1620             


Gly Thr  Leu Asn Ser Thr Leu  Trp Trp Glu Arg Thr  Gln Glu Asp 
    1625                 1630                 1635             


Arg Val  Val Phe 
    1640         


<210>  39
<211>  1617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA6__Homo_sapiens__NP_525023

<400>  39

Met Asn Met Lys Gln Lys Ser Val Tyr Gln Gln Thr Lys Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Phe Leu Lys Lys Trp Arg Met Lys Arg Glu Ser Leu Leu 
            20                  25                  30          


Glu Trp Gly Leu Ser Ile Leu Leu Gly Leu Cys Ile Ala Leu Phe Ser 
        35                  40                  45              


Ser Ser Met Arg Asn Val Gln Phe Pro Gly Met Ala Pro Gln Asn Leu 
    50                  55                  60                  


Gly Arg Val Asp Lys Phe Asn Ser Ser Ser Leu Met Val Val Tyr Thr 
65                  70                  75                  80  


Pro Ile Ser Asn Leu Thr Gln Gln Ile Met Asn Lys Thr Ala Leu Ala 
                85                  90                  95      


Pro Leu Leu Lys Gly Thr Ser Val Ile Gly Ala Pro Asn Lys Thr His 
            100                 105                 110         


Met Asp Glu Ile Leu Leu Glu Asn Leu Pro Tyr Ala Met Gly Ile Ile 
        115                 120                 125             


Phe Asn Glu Thr Phe Ser Tyr Lys Leu Ile Phe Phe Gln Gly Tyr Asn 
    130                 135                 140                 


Ser Pro Leu Trp Lys Glu Asp Phe Ser Ala His Cys Trp Asp Gly Tyr 
145                 150                 155                 160 


Gly Glu Phe Ser Cys Thr Leu Thr Lys Tyr Trp Asn Arg Gly Phe Val 
                165                 170                 175     


Ala Leu Gln Thr Ala Ile Asn Thr Ala Ile Ile Glu Ile Thr Thr Asn 
            180                 185                 190         


His Pro Val Met Glu Glu Leu Met Ser Val Thr Ala Ile Thr Met Lys 
        195                 200                 205             


Thr Leu Pro Phe Ile Thr Lys Asn Leu Leu His Asn Glu Met Phe Ile 
    210                 215                 220                 


Leu Phe Phe Leu Leu His Phe Ser Pro Leu Val Tyr Phe Ile Ser Leu 
225                 230                 235                 240 


Asn Val Thr Lys Glu Arg Lys Lys Ser Lys Asn Leu Met Lys Met Met 
                245                 250                 255     


Gly Leu Gln Asp Ser Ala Phe Trp Leu Ser Trp Gly Leu Ile Tyr Ala 
            260                 265                 270         


Gly Phe Ile Phe Ile Ile Ser Ile Phe Val Thr Ile Ile Ile Thr Phe 
        275                 280                 285             


Thr Gln Ile Ile Val Met Thr Gly Phe Met Val Ile Phe Ile Leu Phe 
    290                 295                 300                 


Phe Leu Tyr Gly Leu Ser Leu Val Ala Leu Val Phe Leu Met Ser Val 
305                 310                 315                 320 


Leu Leu Lys Lys Ala Val Leu Thr Asn Leu Val Val Phe Leu Leu Thr 
                325                 330                 335     


Leu Phe Trp Gly Cys Leu Gly Phe Thr Val Phe Tyr Glu Gln Leu Pro 
            340                 345                 350         


Ser Ser Leu Glu Trp Ile Leu Asn Ile Cys Ser Pro Phe Ala Phe Thr 
        355                 360                 365             


Thr Gly Met Ile Gln Ile Ile Lys Leu Asp Tyr Asn Leu Asn Gly Val 
    370                 375                 380                 


Ile Phe Pro Asp Pro Ser Gly Asp Ser Tyr Thr Met Ile Ala Thr Phe 
385                 390                 395                 400 


Ser Met Leu Leu Leu Asp Gly Leu Ile Tyr Leu Leu Leu Ala Leu Tyr 
                405                 410                 415     


Phe Asp Lys Ile Leu Pro Tyr Gly Asp Glu Arg His Tyr Ser Pro Leu 
            420                 425                 430         


Phe Phe Leu Asn Ser Ser Ser Cys Phe Gln His Gln Arg Thr Asn Ala 
        435                 440                 445             


Lys Val Ile Glu Lys Glu Ile Asp Ala Glu His Pro Ser Asp Asp Tyr 
    450                 455                 460                 


Phe Glu Pro Val Ala Pro Glu Phe Gln Gly Lys Glu Ala Ile Arg Ile 
465                 470                 475                 480 


Arg Asn Val Lys Lys Glu Tyr Lys Gly Lys Ser Gly Lys Val Glu Ala 
                485                 490                 495     


Leu Lys Gly Leu Leu Phe Asp Ile Tyr Glu Gly Gln Ile Thr Ala Ile 
            500                 505                 510         


Leu Gly His Ser Gly Ala Gly Lys Ser Ser Leu Leu Asn Ile Leu Asn 
        515                 520                 525             


Gly Leu Ser Val Pro Thr Glu Gly Ser Val Thr Ile Tyr Asn Lys Asn 
    530                 535                 540                 


Leu Ser Glu Met Gln Asp Leu Glu Glu Ile Arg Lys Ile Thr Gly Val 
545                 550                 555                 560 


Cys Pro Gln Phe Asn Val Gln Phe Asp Ile Leu Thr Val Lys Glu Asn 
                565                 570                 575     


Leu Ser Leu Phe Ala Lys Ile Lys Gly Ile His Leu Lys Glu Val Glu 
            580                 585                 590         


Gln Glu Val Gln Arg Ile Leu Leu Glu Leu Asp Met Gln Asn Ile Gln 
        595                 600                 605             


Asp Asn Leu Ala Lys His Leu Ser Glu Gly Gln Lys Arg Lys Leu Thr 
    610                 615                 620                 


Phe Gly Ile Thr Ile Leu Gly Asp Pro Gln Ile Leu Leu Leu Asp Glu 
625                 630                 635                 640 


Pro Thr Thr Gly Leu Asp Pro Phe Ser Arg Asp Gln Val Trp Ser Leu 
                645                 650                 655     


Leu Arg Glu Arg Arg Ala Asp His Val Ile Leu Phe Ser Thr Gln Ser 
            660                 665                 670         


Met Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Ile Met Ser Asn 
        675                 680                 685             


Gly Arg Leu Lys Cys Ala Gly Ser Ser Met Phe Leu Lys Arg Arg Trp 
    690                 695                 700                 


Gly Leu Gly Tyr His Leu Ser Leu His Arg Asn Glu Ile Cys Asn Pro 
705                 710                 715                 720 


Glu Gln Ile Thr Ser Phe Ile Thr His His Ile Pro Asp Ala Lys Leu 
                725                 730                 735     


Lys Thr Glu Asn Lys Glu Lys Leu Val Tyr Thr Leu Pro Leu Glu Arg 
            740                 745                 750         


Thr Asn Thr Phe Pro Asp Leu Phe Ser Asp Leu Asp Lys Cys Ser Asp 
        755                 760                 765             


Gln Gly Val Thr Gly Tyr Asp Ile Ser Met Ser Thr Leu Asn Glu Val 
    770                 775                 780                 


Phe Met Lys Leu Glu Gly Gln Ser Thr Ile Glu Gln Asp Phe Glu Gln 
785                 790                 795                 800 


Val Glu Met Ile Arg Asp Ser Glu Ser Leu Asn Glu Met Glu Leu Ala 
                805                 810                 815     


His Ser Ser Phe Ser Glu Met Gln Thr Ala Val Ser Asp Met Gly Leu 
            820                 825                 830         


Trp Arg Met Gln Val Phe Ala Met Ala Arg Leu Arg Phe Leu Lys Leu 
        835                 840                 845             


Lys Arg Gln Thr Lys Val Leu Leu Thr Leu Leu Leu Val Phe Gly Ile 
    850                 855                 860                 


Ala Ile Phe Pro Leu Ile Val Glu Asn Ile Met Tyr Ala Met Leu Asn 
865                 870                 875                 880 


Glu Lys Ile Asp Trp Glu Phe Lys Asn Glu Leu Tyr Phe Leu Ser Pro 
                885                 890                 895     


Gly Gln Leu Pro Gln Glu Pro Arg Thr Ser Leu Leu Ile Ile Asn Asn 
            900                 905                 910         


Thr Glu Ser Asn Ile Glu Asp Phe Ile Lys Ser Leu Lys His Gln Asn 
        915                 920                 925             


Ile Leu Leu Glu Val Asp Asp Phe Glu Asn Arg Asn Gly Thr Asp Gly 
    930                 935                 940                 


Leu Ser Tyr Asn Gly Ala Ile Ile Val Ser Gly Lys Gln Lys Asp Tyr 
945                 950                 955                 960 


Arg Phe Ser Val Val Cys Asn Thr Lys Arg Leu His Cys Phe Pro Ile 
                965                 970                 975     


Leu Met Asn Ile Ile Ser Asn Gly Leu Leu Gln Met Phe Asn His Thr 
            980                 985                 990         


Gln His Ile Arg Ile Glu Ser Ser  Pro Phe Pro Leu Ser  His Ile Gly 
        995                 1000                 1005             


Leu Trp  Thr Gly Leu Pro Asp  Gly Ser Phe Phe Leu  Phe Leu Val 
    1010                 1015                 1020             


Leu Cys  Ser Ile Ser Pro Tyr  Ile Thr Met Gly Ser  Ile Ser Asp 
    1025                 1030                 1035             


Tyr Lys  Lys Asn Ala Lys Ser  Gln Leu Trp Ile Ser  Gly Leu Tyr 
    1040                 1045                 1050             


Thr Ser  Ala Tyr Trp Cys Gly  Gln Ala Leu Val Asp  Val Ser Phe 
    1055                 1060                 1065             


Phe Ile  Leu Ile Leu Leu Leu  Met Tyr Leu Ile Phe  Tyr Ile Glu 
    1070                 1075                 1080             


Asn Met  Gln Tyr Leu Leu Ile  Thr Ser Gln Ile Val  Phe Ala Leu 
    1085                 1090                 1095             


Val Ile  Val Thr Pro Gly Tyr  Ala Ala Ser Leu Val  Phe Phe Ile 
    1100                 1105                 1110             


Tyr Met  Ile Ser Phe Ile Phe  Arg Lys Arg Arg Lys  Asn Ser Gly 
    1115                 1120                 1125             


Leu Trp  Ser Phe Tyr Phe Phe  Phe Ala Ser Thr Ile  Met Phe Ser 
    1130                 1135                 1140             


Ile Thr  Leu Ile Asn His Phe  Asp Leu Ser Ile Leu  Ile Thr Thr 
    1145                 1150                 1155             


Met Val  Leu Val Pro Ser Tyr  Thr Leu Leu Gly Phe  Lys Thr Phe 
    1160                 1165                 1170             


Leu Glu  Val Arg Asp Gln Glu  His Tyr Arg Glu Phe  Pro Glu Ala 
    1175                 1180                 1185             


Asn Phe  Glu Leu Ser Ala Thr  Asp Phe Leu Val Cys  Phe Ile Pro 
    1190                 1195                 1200             


Tyr Phe  Gln Thr Leu Leu Phe  Val Phe Val Leu Arg  Cys Met Glu 
    1205                 1210                 1215             


Leu Lys  Cys Gly Lys Lys Arg  Met Arg Lys Asp Pro  Val Phe Arg 
    1220                 1225                 1230             


Ile Ser  Pro Gln Ser Arg Asp  Ala Lys Pro Asn Pro  Glu Glu Pro 
    1235                 1240                 1245             


Ile Asp  Glu Asp Glu Asp Ile  Gln Thr Glu Arg Ile  Arg Thr Ala 
    1250                 1255                 1260             


Thr Ala  Leu Thr Thr Ser Ile  Leu Asp Glu Lys Pro  Val Ile Ile 
    1265                 1270                 1275             


Ala Ser  Cys Leu His Lys Glu  Tyr Ala Gly Gln Lys  Lys Ser Cys 
    1280                 1285                 1290             


Phe Ser  Lys Arg Lys Lys Lys  Ile Ala Ala Arg Asn  Ile Ser Phe 
    1295                 1300                 1305             


Cys Val  Gln Glu Gly Glu Ile  Leu Gly Leu Leu Gly  Pro Asn Gly 
    1310                 1315                 1320             


Ala Gly  Lys Ser Ser Ser Ile  Arg Met Ile Ser Gly  Ile Thr Lys 
    1325                 1330                 1335             


Pro Thr  Ala Gly Glu Val Glu  Leu Lys Gly Cys Ser  Ser Val Leu 
    1340                 1345                 1350             


Gly His  Leu Gly Tyr Cys Pro  Gln Glu Asn Val Leu  Trp Pro Met 
    1355                 1360                 1365             


Leu Thr  Leu Arg Glu His Leu  Glu Val Tyr Ala Ala  Val Lys Gly 
    1370                 1375                 1380             


Leu Arg  Lys Ala Asp Ala Arg  Leu Ala Ile Ala Arg  Leu Val Ser 
    1385                 1390                 1395             


Ala Phe  Lys Leu His Glu Gln  Leu Asn Val Pro Val  Gln Lys Leu 
    1400                 1405                 1410             


Thr Ala  Gly Ile Thr Arg Lys  Leu Cys Phe Val Leu  Ser Leu Leu 
    1415                 1420                 1425             


Gly Asn  Ser Pro Val Leu Leu  Leu Asp Glu Pro Ser  Thr Gly Ile 
    1430                 1435                 1440             


Asp Pro  Thr Gly Gln Gln Gln  Met Trp Gln Ala Ile  Gln Ala Val 
    1445                 1450                 1455             


Val Lys  Asn Thr Glu Arg Gly  Val Leu Leu Thr Thr  His Asn Leu 
    1460                 1465                 1470             


Ala Glu  Ala Glu Ala Leu Cys  Asp Arg Val Ala Ile  Met Val Ser 
    1475                 1480                 1485             


Gly Arg  Leu Arg Cys Ile Gly  Ser Ile Gln His Leu  Lys Asn Lys 
    1490                 1495                 1500             


Leu Gly  Lys Asp Tyr Ile Leu  Glu Leu Lys Val Lys  Glu Thr Ser 
    1505                 1510                 1515             


Gln Val  Thr Leu Val His Thr  Glu Ile Leu Lys Leu  Phe Pro Gln 
    1520                 1525                 1530             


Ala Ala  Gly Gln Glu Arg Tyr  Ser Ser Leu Leu Thr  Tyr Lys Leu 
    1535                 1540                 1545             


Pro Val  Ala Asp Val Tyr Pro  Leu Ser Gln Thr Phe  His Lys Leu 
    1550                 1555                 1560             


Glu Ala  Val Lys His Asn Phe  Asn Leu Glu Glu Tyr  Ser Leu Ser 
    1565                 1570                 1575             


Gln Cys  Thr Leu Glu Lys Val  Phe Leu Glu Leu Ser  Lys Glu Gln 
    1580                 1585                 1590             


Glu Val  Gly Asn Phe Asp Glu  Glu Ile Asp Thr Thr  Met Arg Trp 
    1595                 1600                 1605             


Lys Leu  Leu Pro His Ser Asp  Glu Pro 
    1610                 1615         


<210>  40
<211>  2146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA7__Homo_sapiens__NP_061985

<400>  40

Met Ala Phe Trp Thr Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      


Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 
            20                  25                  30          


Leu Phe Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro 
        35                  40                  45              


Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala 
    50                  55                  60                  


Gly Thr Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Thr 
65                  70                  75                  80  


Cys Phe Pro Gln Leu Thr Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 
                85                  90                  95      


Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Thr Val 
            100                 105                 110         


Leu Gly Gly Ala Ser Ala His Arg Thr Leu Ala Gly Leu Gly Lys Leu 
        115                 120                 125             


Ile Ala Thr Leu Arg Ala Ala Arg Ser Thr Ala Gln Pro Gln Pro Thr 
    130                 135                 140                 


Lys Gln Ser Pro Leu Glu Pro Pro Met Leu Asp Val Ala Glu Leu Leu 
145                 150                 155                 160 


Thr Ser Leu Leu Arg Thr Glu Ser Leu Gly Leu Ala Leu Gly Gln Ala 
                165                 170                 175     


Gln Glu Pro Leu His Ser Leu Leu Glu Ala Ala Glu Asp Leu Ala Gln 
            180                 185                 190         


Glu Leu Leu Ala Leu Arg Ser Leu Val Glu Leu Arg Ala Leu Leu Gln 
        195                 200                 205             


Arg Pro Arg Gly Thr Ser Gly Pro Leu Glu Leu Leu Ser Glu Ala Leu 
    210                 215                 220                 


Cys Ser Val Arg Gly Pro Ser Ser Thr Val Gly Pro Ser Leu Asn Trp 
225                 230                 235                 240 


Tyr Glu Ala Ser Asp Leu Met Glu Leu Val Gly Gln Glu Pro Glu Ser 
                245                 250                 255     


Ala Leu Pro Asp Ser Ser Leu Ser Pro Ala Cys Ser Glu Leu Ile Gly 
            260                 265                 270         


Ala Leu Asp Ser His Pro Leu Ser Arg Leu Leu Trp Arg Arg Leu Lys 
        275                 280                 285             


Pro Leu Ile Leu Gly Lys Leu Leu Phe Ala Pro Asp Thr Pro Phe Thr 
    290                 295                 300                 


Arg Lys Leu Met Ala Gln Val Asn Arg Thr Phe Glu Glu Leu Thr Leu 
305                 310                 315                 320 


Leu Arg Asp Val Arg Glu Val Trp Glu Met Leu Gly Pro Arg Ile Phe 
                325                 330                 335     


Thr Phe Met Asn Asp Ser Ser Asn Val Ala Met Leu Gln Arg Leu Leu 
            340                 345                 350         


Gln Met Gln Asp Glu Gly Arg Arg Gln Pro Arg Pro Gly Gly Arg Asp 
        355                 360                 365             


His Met Glu Ala Leu Arg Ser Phe Leu Asp Pro Gly Ser Gly Gly Tyr 
    370                 375                 380                 


Ser Trp Gln Asp Ala His Ala Asp Val Gly His Leu Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Val Thr Glu Cys Leu Ser Leu Asp Lys Leu Glu Ala Ala Pro 
                405                 410                 415     


Ser Glu Ala Ala Leu Val Ser Arg Ala Leu Gln Leu Leu Ala Glu His 
            420                 425                 430         


Arg Phe Trp Ala Gly Val Val Phe Leu Gly Pro Glu Asp Ser Ser Asp 
        435                 440                 445             


Pro Thr Glu His Pro Thr Pro Asp Leu Gly Pro Gly His Val Arg Ile 
    450                 455                 460                 


Lys Ile Arg Met Asp Ile Asp Val Val Thr Arg Thr Asn Lys Ile Arg 
465                 470                 475                 480 


Asp Arg Phe Trp Asp Pro Gly Pro Ala Ala Asp Pro Leu Thr Asp Leu 
                485                 490                 495     


Arg Tyr Val Trp Gly Gly Phe Val Tyr Leu Gln Asp Leu Val Glu Arg 
            500                 505                 510         


Ala Ala Val Arg Val Leu Ser Gly Ala Asn Pro Arg Ala Gly Leu Tyr 
        515                 520                 525             


Leu Gln Gln Met Pro Tyr Pro Cys Tyr Val Asp Asp Val Phe Leu Arg 
    530                 535                 540                 


Val Leu Ser Arg Ser Leu Pro Leu Phe Leu Thr Leu Ala Trp Ile Tyr 
545                 550                 555                 560 


Ser Val Thr Leu Thr Val Lys Ala Val Val Arg Glu Lys Glu Thr Arg 
                565                 570                 575     


Leu Arg Asp Thr Met Arg Ala Met Gly Leu Ser Arg Ala Val Leu Trp 
            580                 585                 590         


Leu Gly Trp Phe Leu Ser Cys Leu Gly Pro Phe Leu Leu Ser Ala Ala 
        595                 600                 605             


Leu Leu Val Leu Val Leu Lys Leu Gly Asp Ile Leu Pro Tyr Ser His 
    610                 615                 620                 


Pro Gly Val Val Phe Leu Phe Leu Ala Ala Phe Ala Val Ala Thr Val 
625                 630                 635                 640 


Thr Gln Ser Phe Leu Leu Ser Ala Phe Phe Ser Arg Ala Asn Leu Ala 
                645                 650                 655     


Ala Ala Cys Gly Gly Leu Ala Tyr Phe Ser Leu Tyr Leu Pro Tyr Val 
            660                 665                 670         


Leu Cys Val Ala Trp Arg Asp Arg Leu Pro Ala Gly Gly Arg Val Ala 
        675                 680                 685             


Ala Ser Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Cys Glu Ser Leu 
    690                 695                 700                 


Ala Leu Leu Glu Glu Gln Gly Glu Gly Ala Gln Trp His Asn Val Gly 
705                 710                 715                 720 


Thr Arg Pro Thr Ala Asp Val Phe Ser Leu Ala Gln Val Ser Gly Leu 
                725                 730                 735     


Leu Leu Leu Asp Ala Ala Leu Tyr Gly Leu Ala Thr Trp Tyr Leu Glu 
            740                 745                 750         


Ala Val Cys Pro Gly Gln Tyr Gly Ile Pro Glu Pro Trp Asn Phe Pro 
        755                 760                 765             


Phe Arg Arg Ser Tyr Trp Cys Gly Pro Arg Pro Pro Lys Ser Pro Ala 
    770                 775                 780                 


Pro Cys Pro Thr Pro Leu Asp Pro Lys Val Leu Val Glu Glu Ala Pro 
785                 790                 795                 800 


Pro Gly Leu Ser Pro Gly Val Ser Val Arg Ser Leu Glu Lys Arg Phe 
                805                 810                 815     


Pro Gly Ser Pro Gln Pro Ala Leu Arg Gly Leu Ser Leu Asp Phe Tyr 
            820                 825                 830         


Gln Gly His Ile Thr Ala Phe Leu Gly His Asn Gly Ala Gly Lys Thr 
        835                 840                 845             


Thr Thr Leu Ser Ile Leu Ser Gly Leu Phe Pro Pro Ser Gly Gly Ser 
    850                 855                 860                 


Ala Phe Ile Leu Gly His Asp Val Arg Ser Ser Met Ala Ala Ile Arg 
865                 870                 875                 880 


Pro His Leu Gly Val Cys Pro Gln Tyr Asn Val Leu Phe Asp Met Leu 
                885                 890                 895     


Thr Val Asp Glu His Val Trp Phe Tyr Gly Arg Leu Lys Gly Leu Ser 
            900                 905                 910         


Ala Ala Val Val Gly Pro Glu Gln Asp Arg Leu Leu Gln Asp Val Gly 
        915                 920                 925             


Leu Val Ser Lys Gln Ser Val Gln Thr Arg His Leu Ser Gly Gly Met 
    930                 935                 940                 


Gln Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Gly Ser Gln Val 
945                 950                 955                 960 


Val Ile Leu Asp Glu Pro Thr Ala Gly Val Asp Pro Ala Ser Arg Arg 
                965                 970                 975     


Gly Ile Trp Glu Leu Leu Leu Lys Tyr Arg Glu Gly Arg Thr Leu Ile 
            980                 985                 990         


Leu Ser Thr His His Leu Asp Glu  Ala Glu Leu Leu Gly  Asp Arg Val 
        995                 1000                 1005             


Ala Val  Val Ala Gly Gly Arg  Leu Cys Cys Cys Gly  Ser Pro Leu 
    1010                 1015                 1020             


Phe Leu  Arg Arg His Leu Gly  Ser Gly Tyr Tyr Leu  Thr Leu Val 
    1025                 1030                 1035             


Lys Ala  Arg Leu Pro Leu Thr  Thr Asn Glu Lys Ala  Asp Thr Asp 
    1040                 1045                 1050             


Met Glu  Gly Ser Val Asp Thr  Arg Gln Glu Lys Lys  Asn Gly Ser 
    1055                 1060                 1065             


Gln Gly  Ser Arg Val Gly Thr  Pro Gln Leu Leu Ala  Leu Val Gln 
    1070                 1075                 1080             


His Trp  Val Pro Gly Ala Arg  Leu Val Glu Glu Leu  Pro His Glu 
    1085                 1090                 1095             


Leu Val  Leu Val Leu Pro Tyr  Thr Gly Ala His Asp  Gly Ser Phe 
    1100                 1105                 1110             


Ala Thr  Leu Phe Arg Glu Leu  Asp Thr Arg Leu Ala  Glu Leu Arg 
    1115                 1120                 1125             


Leu Thr  Gly Tyr Gly Ile Ser  Asp Thr Ser Leu Glu  Glu Ile Phe 
    1130                 1135                 1140             


Leu Lys  Val Val Glu Glu Cys  Ala Ala Asp Thr Asp  Met Glu Asp 
    1145                 1150                 1155             


Gly Ser  Cys Gly Gln His Leu  Cys Thr Gly Ile Ala  Gly Leu Asp 
    1160                 1165                 1170             


Val Thr  Leu Arg Leu Lys Met  Pro Pro Gln Glu Thr  Ala Leu Glu 
    1175                 1180                 1185             


Asn Gly  Glu Pro Ala Gly Ser  Ala Pro Glu Thr Asp  Gln Gly Ser 
    1190                 1195                 1200             


Gly Pro  Asp Ala Val Gly Arg  Val Gln Gly Trp Ala  Leu Thr Arg 
    1205                 1210                 1215             


Gln Gln  Leu Gln Ala Leu Leu  Leu Lys Arg Phe Leu  Leu Ala Arg 
    1220                 1225                 1230             


Arg Ser  Arg Arg Gly Leu Phe  Ala Gln Ile Val Leu  Pro Ala Leu 
    1235                 1240                 1245             


Phe Val  Gly Leu Ala Leu Val  Phe Ser Leu Ile Val  Pro Pro Phe 
    1250                 1255                 1260             


Gly His  Tyr Pro Ala Leu Arg  Leu Ser Pro Thr Met  Tyr Gly Ala 
    1265                 1270                 1275             


Gln Val  Ser Phe Phe Ser Glu  Asp Ala Pro Gly Asp  Pro Gly Arg 
    1280                 1285                 1290             


Ala Arg  Leu Leu Glu Ala Leu  Leu Gln Glu Ala Gly  Leu Glu Glu 
    1295                 1300                 1305             


Pro Pro  Val Gln His Ser Ser  His Arg Phe Ser Ala  Pro Glu Val 
    1310                 1315                 1320             


Pro Ala  Glu Val Ala Lys Val  Leu Ala Ser Gly Asn  Trp Thr Pro 
    1325                 1330                 1335             


Glu Ser  Pro Ser Pro Ala Cys  Gln Cys Ser Arg Pro  Gly Ala Arg 
    1340                 1345                 1350             


Arg Leu  Leu Pro Asp Cys Pro  Ala Ala Ala Gly Gly  Pro Pro Pro 
    1355                 1360                 1365             


Pro Gln  Ala Val Thr Gly Ser  Gly Glu Val Val Gln  Asn Leu Thr 
    1370                 1375                 1380             


Gly Arg  Asn Leu Ser Asp Phe  Leu Val Lys Thr Tyr  Pro Arg Leu 
    1385                 1390                 1395             


Val Arg  Gln Gly Leu Lys Thr  Lys Lys Trp Val Asn  Glu Val Arg 
    1400                 1405                 1410             


Tyr Gly  Gly Phe Ser Leu Gly  Gly Arg Asp Pro Gly  Leu Pro Ser 
    1415                 1420                 1425             


Gly Gln  Glu Leu Gly Arg Ser  Val Glu Glu Leu Trp  Ala Leu Leu 
    1430                 1435                 1440             


Ser Pro  Leu Pro Gly Gly Ala  Leu Asp Arg Val Leu  Lys Asn Leu 
    1445                 1450                 1455             


Thr Ala  Trp Ala His Ser Leu  Asp Ala Gln Asp Ser  Leu Lys Ile 
    1460                 1465                 1470             


Trp Phe  Asn Asn Lys Gly Trp  His Ser Met Val Ala  Phe Val Asn 
    1475                 1480                 1485             


Arg Ala  Ser Asn Ala Ile Leu  Arg Ala His Leu Pro  Pro Gly Pro 
    1490                 1495                 1500             


Ala Arg  His Ala His Ser Ile  Thr Thr Leu Asn His  Pro Leu Asn 
    1505                 1510                 1515             


Leu Thr  Lys Glu Gln Leu Ser  Glu Gly Ala Leu Met  Ala Ser Ser 
    1520                 1525                 1530             


Val Asp  Val Leu Val Ser Ile  Cys Val Val Phe Ala  Met Ser Phe 
    1535                 1540                 1545             


Val Pro  Ala Ser Phe Thr Leu  Val Leu Ile Glu Glu  Arg Val Thr 
    1550                 1555                 1560             


Arg Ala  Lys His Leu Gln Leu  Met Gly Gly Leu Ser  Pro Thr Leu 
    1565                 1570                 1575             


Tyr Trp  Leu Gly Asn Phe Leu  Trp Asp Met Cys Asn  Tyr Leu Val 
    1580                 1585                 1590             


Pro Ala  Cys Ile Val Val Leu  Ile Phe Leu Ala Phe  Gln Gln Arg 
    1595                 1600                 1605             


Ala Tyr  Val Ala Pro Ala Asn  Leu Pro Ala Leu Leu  Leu Leu Leu 
    1610                 1615                 1620             


Leu Leu  Tyr Gly Trp Ser Ile  Thr Pro Leu Met Tyr  Pro Ala Ser 
    1625                 1630                 1635             


Phe Phe  Phe Ser Val Pro Ser  Thr Ala Tyr Val Val  Leu Thr Cys 
    1640                 1645                 1650             


Ile Asn  Leu Phe Ile Gly Ile  Asn Gly Ser Met Ala  Thr Phe Val 
    1655                 1660                 1665             


Leu Glu  Leu Phe Ser Asp Gln  Lys Leu Gln Glu Val  Ser Arg Ile 
    1670                 1675                 1680             


Leu Lys  Gln Val Phe Leu Ile  Phe Pro His Phe Cys  Leu Gly Arg 
    1685                 1690                 1695             


Gly Leu  Ile Asp Met Val Arg  Asn Gln Ala Met Ala  Asp Ala Phe 
    1700                 1705                 1710             


Glu Arg  Leu Gly Asp Arg Gln  Phe Gln Ser Pro Leu  Arg Trp Glu 
    1715                 1720                 1725             


Val Val  Gly Lys Asn Leu Leu  Ala Met Val Ile Gln  Gly Pro Leu 
    1730                 1735                 1740             


Phe Leu  Leu Phe Thr Leu Leu  Leu Gln His Arg Ser  Gln Leu Leu 
    1745                 1750                 1755             


Pro Gln  Pro Arg Val Arg Ser  Leu Pro Leu Leu Gly  Glu Glu Asp 
    1760                 1765                 1770             


Glu Asp  Val Ala Arg Glu Arg  Glu Arg Val Val Gln  Gly Ala Thr 
    1775                 1780                 1785             


Gln Gly  Asp Val Leu Val Leu  Arg Asn Leu Thr Lys  Val Tyr Arg 
    1790                 1795                 1800             


Gly Gln  Arg Met Pro Ala Val  Asp Arg Leu Cys Leu  Gly Ile Pro 
    1805                 1810                 1815             


Pro Gly  Glu Cys Phe Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys 
    1820                 1825                 1830             


Thr Ser  Thr Phe Arg Met Val  Thr Gly Asp Thr Leu  Ala Ser Arg 
    1835                 1840                 1845             


Gly Glu  Ala Val Leu Ala Gly  His Ser Val Ala Arg  Glu Pro Ser 
    1850                 1855                 1860             


Ala Ala  His Leu Ser Met Gly  Tyr Cys Pro Gln Ser  Asp Ala Ile 
    1865                 1870                 1875             


Phe Glu  Leu Leu Thr Gly Arg  Glu His Leu Glu Leu  Leu Ala Arg 
    1880                 1885                 1890             


Leu Arg  Gly Val Pro Glu Ala  Gln Val Ala Gln Thr  Ala Gly Ser 
    1895                 1900                 1905             


Gly Leu  Ala Arg Leu Gly Leu  Ser Trp Tyr Ala Asp  Arg Pro Ala 
    1910                 1915                 1920             


Gly Thr  Tyr Ser Gly Gly Asn  Lys Arg Lys Leu Ala  Thr Ala Leu 
    1925                 1930                 1935             


Ala Leu  Val Gly Asp Pro Ala  Val Val Phe Leu Asp  Glu Pro Thr 
    1940                 1945                 1950             


Thr Gly  Met Asp Pro Ser Ala  Arg Arg Phe Leu Trp  Asn Ser Leu 
    1955                 1960                 1965             


Leu Ala  Val Val Arg Glu Gly  Arg Ser Val Met Leu  Thr Ser His 
    1970                 1975                 1980             


Ser Met  Glu Glu Cys Glu Ala  Leu Cys Ser Arg Leu  Ala Ile Met 
    1985                 1990                 1995             


Val Asn  Gly Arg Phe Arg Cys  Leu Gly Ser Pro Gln  His Leu Lys 
    2000                 2005                 2010             


Gly Arg  Phe Ala Ala Gly His  Thr Leu Thr Leu Arg  Val Pro Ala 
    2015                 2020                 2025             


Ala Arg  Ser Gln Pro Ala Ala  Ala Phe Val Ala Ala  Glu Phe Pro 
    2030                 2035                 2040             


Gly Ala  Glu Leu Arg Glu Ala  His Gly Gly Arg Leu  Arg Phe Gln 
    2045                 2050                 2055             


Leu Pro  Pro Gly Gly Arg Cys  Ala Leu Ala Arg Val  Phe Gly Glu 
    2060                 2065                 2070             


Leu Ala  Val His Gly Ala Glu  His Gly Val Glu Asp  Phe Ser Val 
    2075                 2080                 2085             


Ser Gln  Thr Met Leu Glu Glu  Val Phe Leu Tyr Phe  Ser Lys Asp 
    2090                 2095                 2100             


Gln Gly  Lys Asp Glu Asp Thr  Glu Glu Gln Lys Glu  Ala Gly Val 
    2105                 2110                 2115             


Gly Val  Asp Pro Ala Pro Gly  Leu Gln His Pro Lys  Arg Val Ser 
    2120                 2125                 2130             


Gln Phe  Leu Asp Asp Pro Ser  Thr Ala Glu Thr Val  Leu 
    2135                 2140                 2145     


<210>  41
<211>  1624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCA9__Homo_sapiens__NP_525022

<400>  41

Met Ser Lys Arg Arg Met Ser Val Gly Gln Gln Thr Trp Ala Leu Leu 
1               5                   10                  15      


Cys Lys Asn Cys Leu Lys Lys Trp Arg Met Lys Arg Gln Thr Leu Leu 
            20                  25                  30          


Glu Trp Leu Phe Ser Phe Leu Leu Val Leu Phe Leu Tyr Leu Phe Phe 
        35                  40                  45              


Ser Asn Leu His Gln Val His Asp Thr Pro Gln Met Ser Ser Met Asp 
    50                  55                  60                  


Leu Gly Arg Val Asp Ser Phe Asn Asp Thr Asn Tyr Val Ile Ala Phe 
65                  70                  75                  80  


Ala Pro Glu Ser Lys Thr Thr Gln Glu Ile Met Asn Lys Val Ala Ser 
                85                  90                  95      


Ala Pro Phe Leu Lys Gly Arg Thr Ile Met Gly Trp Pro Asp Glu Lys 
            100                 105                 110         


Ser Met Asp Glu Leu Asp Leu Asn Tyr Ser Ile Asp Ala Val Arg Val 
        115                 120                 125             


Ile Phe Thr Asp Thr Phe Ser Tyr His Leu Lys Phe Ser Trp Gly His 
    130                 135                 140                 


Arg Ile Pro Met Met Lys Glu His Arg Asp His Ser Ala His Cys Gln 
145                 150                 155                 160 


Ala Val Asn Glu Lys Met Lys Cys Glu Gly Ser Glu Phe Trp Glu Lys 
                165                 170                 175     


Gly Phe Val Ala Phe Gln Ala Ala Ile Asn Ala Ala Ile Ile Glu Ile 
            180                 185                 190         


Ala Thr Asn His Ser Val Met Glu Gln Leu Met Ser Val Thr Gly Val 
        195                 200                 205             


His Met Lys Ile Leu Pro Phe Val Ala Gln Gly Gly Val Ala Thr Asp 
    210                 215                 220                 


Phe Phe Ile Phe Phe Cys Ile Ile Ser Phe Ser Thr Phe Ile Tyr Tyr 
225                 230                 235                 240 


Val Ser Val Asn Val Thr Gln Glu Arg Gln Tyr Ile Thr Ser Leu Met 
                245                 250                 255     


Thr Met Met Gly Leu Arg Glu Ser Ala Phe Trp Leu Ser Trp Gly Leu 
            260                 265                 270         


Met Tyr Ala Gly Phe Ile Leu Ile Met Ala Thr Leu Met Ala Leu Ile 
        275                 280                 285             


Val Lys Ser Ala Gln Ile Val Val Leu Thr Gly Phe Val Met Val Phe 
    290                 295                 300                 


Thr Leu Phe Leu Leu Tyr Gly Leu Ser Leu Ile Thr Leu Ala Phe Leu 
305                 310                 315                 320 


Met Ser Val Leu Ile Lys Lys Pro Phe Leu Thr Gly Leu Val Val Phe 
                325                 330                 335     


Leu Leu Ile Val Phe Trp Gly Ile Leu Gly Phe Pro Ala Leu Tyr Thr 
            340                 345                 350         


Arg Leu Pro Ala Phe Leu Glu Trp Thr Leu Cys Leu Leu Ser Pro Phe 
        355                 360                 365             


Ala Phe Thr Val Gly Met Ala Gln Leu Ile His Leu Asp Tyr Asp Val 
    370                 375                 380                 


Asn Ser Asn Ala His Leu Asp Ser Ser Gln Asn Pro Tyr Leu Ile Ile 
385                 390                 395                 400 


Ala Thr Leu Phe Met Leu Val Phe Asp Thr Leu Leu Tyr Leu Val Leu 
                405                 410                 415     


Thr Leu Tyr Phe Asp Lys Ile Leu Pro Ala Glu Tyr Gly His Arg Cys 
            420                 425                 430         


Ser Pro Leu Phe Phe Leu Lys Ser Cys Phe Trp Phe Gln His Gly Arg 
        435                 440                 445             


Ala Asn His Val Val Leu Glu Asn Glu Thr Asp Ser Asp Pro Thr Pro 
    450                 455                 460                 


Asn Asp Cys Phe Glu Pro Val Ser Pro Glu Phe Cys Gly Lys Glu Ala 
465                 470                 475                 480 


Ile Arg Ile Lys Asn Leu Lys Lys Glu Tyr Ala Gly Lys Cys Glu Arg 
                485                 490                 495     


Val Glu Ala Leu Lys Gly Val Val Phe Asp Ile Tyr Glu Gly Gln Ile 
            500                 505                 510         


Thr Ala Leu Leu Gly His Ser Gly Ala Gly Lys Thr Thr Leu Leu Asn 
        515                 520                 525             


Ile Leu Ser Gly Leu Ser Val Pro Thr Ser Gly Ser Val Thr Val Tyr 
    530                 535                 540                 


Asn His Thr Leu Ser Arg Met Ala Asp Ile Glu Asn Ile Ser Lys Phe 
545                 550                 555                 560 


Thr Gly Phe Cys Pro Gln Ser Asn Val Gln Phe Gly Phe Leu Thr Val 
                565                 570                 575     


Lys Glu Asn Leu Arg Leu Phe Ala Lys Ile Lys Gly Ile Leu Pro His 
            580                 585                 590         


Glu Val Glu Lys Glu Val Gln Arg Val Val Gln Glu Leu Glu Met Glu 
        595                 600                 605             


Asn Ile Gln Asp Ile Leu Ala Gln Asn Leu Ser Gly Gly Gln Asn Arg 
    610                 615                 620                 


Lys Leu Thr Phe Gly Ile Ala Ile Leu Gly Asp Pro Gln Val Leu Leu 
625                 630                 635                 640 


Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Leu Ser Arg His Arg Ile 
                645                 650                 655     


Trp Asn Leu Leu Lys Glu Gly Lys Ser Asp Arg Val Ile Leu Phe Ser 
            660                 665                 670         


Thr Gln Phe Ile Asp Glu Ala Asp Ile Leu Ala Asp Arg Lys Val Phe 
        675                 680                 685             


Ile Ser Asn Gly Lys Leu Lys Cys Ala Gly Ser Ser Leu Phe Leu Lys 
    690                 695                 700                 


Lys Lys Trp Gly Ile Gly Tyr His Leu Ser Leu His Leu Asn Glu Arg 
705                 710                 715                 720 


Cys Asp Pro Glu Ser Ile Thr Ser Leu Val Lys Gln His Ile Ser Asp 
                725                 730                 735     


Ala Lys Leu Thr Ala Gln Ser Glu Glu Lys Leu Val Tyr Ile Leu Pro 
            740                 745                 750         


Leu Glu Arg Thr Asn Lys Phe Pro Glu Leu Tyr Arg Asp Leu Asp Arg 
        755                 760                 765             


Cys Ser Asn Gln Gly Ile Glu Asp Tyr Gly Val Ser Ile Thr Thr Leu 
    770                 775                 780                 


Asn Glu Val Phe Leu Lys Leu Glu Gly Lys Ser Thr Ile Asp Glu Ser 
785                 790                 795                 800 


Asp Ile Gly Ile Trp Gly Gln Leu Gln Thr Asp Gly Ala Lys Asp Ile 
                805                 810                 815     


Gly Ser Leu Val Glu Leu Glu Gln Val Leu Ser Ser Phe His Glu Thr 
            820                 825                 830         


Arg Lys Thr Ile Ser Gly Val Ala Leu Trp Arg Gln Gln Val Cys Ala 
        835                 840                 845             


Ile Ala Lys Val Arg Phe Leu Lys Leu Lys Lys Glu Arg Lys Ser Leu 
    850                 855                 860                 


Trp Thr Ile Leu Leu Leu Phe Gly Ile Ser Phe Ile Pro Gln Leu Leu 
865                 870                 875                 880 


Glu His Leu Phe Tyr Glu Ser Tyr Gln Lys Ser Tyr Pro Trp Glu Leu 
                885                 890                 895     


Ser Pro Asn Thr Tyr Phe Leu Ser Pro Gly Gln Gln Pro Gln Asp Pro 
            900                 905                 910         


Leu Thr His Leu Leu Val Ile Asn Lys Thr Gly Ser Thr Ile Asp Asn 
        915                 920                 925             


Phe Leu His Ser Leu Arg Arg Gln Asn Ile Ala Ile Glu Val Asp Ala 
    930                 935                 940                 


Phe Gly Thr Arg Asn Gly Thr Asp Asp Pro Ser Tyr Asn Gly Ala Ile 
945                 950                 955                 960 


Ile Val Ser Gly Asp Glu Lys Asp His Arg Phe Ser Ile Ala Cys Asn 
                965                 970                 975     


Thr Lys Arg Leu Asn Cys Phe Pro Val Leu Leu Asp Val Ile Ser Asn 
            980                 985                 990         


Gly Leu Leu Gly Ile Phe Asn Ser  Ser Glu His Ile Gln  Thr Asp Arg 
        995                 1000                 1005             


Ser Thr  Phe Phe Glu Glu His  Met Asp Tyr Glu Tyr  Gly Tyr Arg 
    1010                 1015                 1020             


Ser Asn  Thr Phe Phe Trp Ile  Pro Met Ala Ala Ser  Phe Thr Pro 
    1025                 1030                 1035             


Tyr Ile  Ala Met Ser Ser Ile  Gly Asp Tyr Lys Lys  Lys Ala His 
    1040                 1045                 1050             


Ser Gln  Leu Arg Ile Ser Gly  Leu Tyr Pro Ser Ala  Tyr Trp Phe 
    1055                 1060                 1065             


Gly Gln  Ala Leu Val Asp Val  Ser Leu Tyr Phe Leu  Ile Leu Leu 
    1070                 1075                 1080             


Leu Met  Gln Ile Met Asp Tyr  Ile Phe Ser Pro Glu  Glu Ile Ile 
    1085                 1090                 1095             


Phe Ile  Ile Gln Asn Leu Leu  Ile Gln Ile Leu Cys  Ser Ile Gly 
    1100                 1105                 1110             


Tyr Val  Ser Ser Leu Val Phe  Leu Thr Tyr Val Ile  Ser Phe Ile 
    1115                 1120                 1125             


Phe Arg  Asn Gly Arg Lys Asn  Ser Gly Ile Trp Ser  Phe Phe Phe 
    1130                 1135                 1140             


Leu Ile  Val Val Ile Phe Ser  Ile Val Ala Thr Asp  Leu Asn Glu 
    1145                 1150                 1155             


Tyr Gly  Phe Leu Gly Leu Phe  Phe Gly Thr Met Leu  Ile Pro Pro 
    1160                 1165                 1170             


Phe Thr  Leu Ile Gly Ser Leu  Phe Ile Phe Ser Glu  Ile Ser Pro 
    1175                 1180                 1185             


Asp Ser  Met Asp Tyr Leu Gly  Ala Ser Glu Ser Glu  Ile Val Tyr 
    1190                 1195                 1200             


Leu Ala  Leu Leu Ile Pro Tyr  Leu His Phe Leu Ile  Phe Leu Phe 
    1205                 1210                 1215             


Ile Leu  Arg Cys Leu Glu Met  Asn Cys Arg Lys Lys  Leu Met Arg 
    1220                 1225                 1230             


Lys Asp  Pro Val Phe Arg Ile  Ser Pro Arg Ser Asn  Ala Ile Phe 
    1235                 1240                 1245             


Pro Asn  Pro Glu Glu Pro Glu  Gly Glu Glu Glu Asp  Ile Gln Met 
    1250                 1255                 1260             


Glu Arg  Met Arg Thr Val Asn  Ala Met Ala Val Arg  Asp Phe Asp 
    1265                 1270                 1275             


Glu Thr  Pro Val Ile Ile Ala  Ser Cys Leu Arg Lys  Glu Tyr Ala 
    1280                 1285                 1290             


Gly Lys  Lys Lys Asn Cys Phe  Ser Lys Arg Lys Lys  Lys Ile Ala 
    1295                 1300                 1305             


Thr Arg  Asn Val Ser Phe Cys  Val Lys Lys Gly Glu  Val Ile Gly 
    1310                 1315                 1320             


Leu Leu  Gly His Asn Gly Ala  Gly Lys Ser Thr Thr  Ile Lys Met 
    1325                 1330                 1335             


Ile Thr  Gly Asp Thr Lys Pro  Thr Ala Gly Gln Val  Ile Leu Lys 
    1340                 1345                 1350             


Gly Ser  Gly Gly Gly Glu Pro  Leu Gly Phe Leu Gly  Tyr Cys Pro 
    1355                 1360                 1365             


Gln Glu  Asn Ala Leu Trp Pro  Asn Leu Thr Val Arg  Gln His Leu 
    1370                 1375                 1380             


Glu Val  Tyr Ala Ala Val Lys  Gly Leu Arg Lys Gly  Asp Ala Met 
    1385                 1390                 1395             


Ile Ala  Ile Thr Arg Leu Val  Asp Ala Leu Lys Leu  Gln Asp Gln 
    1400                 1405                 1410             


Leu Lys  Ala Pro Val Lys Thr  Leu Ser Glu Gly Ile  Lys Arg Lys 
    1415                 1420                 1425             


Leu Cys  Phe Val Leu Ser Ile  Leu Gly Asn Pro Ser  Val Val Leu 
    1430                 1435                 1440             


Leu Asp  Glu Pro Ser Thr Gly  Met Asp Pro Glu Gly  Gln Gln Gln 
    1445                 1450                 1455             


Met Trp  Gln Val Ile Arg Ala  Thr Phe Arg Asn Thr  Glu Arg Gly 
    1460                 1465                 1470             


Ala Leu  Leu Thr Thr His Tyr  Met Ala Glu Ala Glu  Ala Val Cys 
    1475                 1480                 1485             


Asp Arg  Val Ala Ile Met Val  Ser Gly Arg Leu Arg  Cys Ile Gly 
    1490                 1495                 1500             


Ser Ile  Gln His Leu Lys Ser  Lys Phe Gly Lys Asp  Tyr Leu Leu 
    1505                 1510                 1515             


Glu Met  Lys Leu Lys Asn Leu  Ala Gln Met Glu Pro  Leu His Ala 
    1520                 1525                 1530             


Glu Ile  Leu Arg Leu Phe Pro  Gln Ala Ala Gln Gln  Glu Arg Phe 
    1535                 1540                 1545             


Ser Ser  Leu Met Val Tyr Lys  Leu Pro Val Glu Asp  Val Arg Pro 
    1550                 1555                 1560             


Leu Ser  Gln Ala Phe Phe Lys  Leu Glu Ile Val Lys  Gln Ser Phe 
    1565                 1570                 1575             


Asp Leu  Glu Glu Tyr Ser Leu  Ser Gln Ser Thr Leu  Glu Gln Val 
    1580                 1585                 1590             


Phe Leu  Glu Leu Ser Lys Glu  Gln Glu Leu Gly Asp  Leu Glu Glu 
    1595                 1600                 1605             


Asp Phe  Asp Pro Ser Val Lys  Trp Lys Leu Leu Leu  Gln Glu Glu 
    1610                 1615                 1620             


Pro 
    


<210>  42
<211>  1321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB11__Homo_sapiens__NP_003733

<400>  42

Met Ser Asp Ser Val Ile Leu Arg Ser Ile Lys Lys Phe Gly Glu Glu 
1               5                   10                  15      


Asn Asp Gly Phe Glu Ser Asp Lys Ser Tyr Asn Asn Asp Lys Lys Ser 
            20                  25                  30          


Arg Leu Gln Asp Glu Lys Lys Gly Asp Gly Val Arg Val Gly Phe Phe 
        35                  40                  45              


Gln Leu Phe Arg Phe Ser Ser Ser Thr Asp Ile Trp Leu Met Phe Val 
    50                  55                  60                  


Gly Ser Leu Cys Ala Phe Leu His Gly Ile Ala Gln Pro Gly Val Leu 
65                  70                  75                  80  


Leu Ile Phe Gly Thr Met Thr Asp Val Phe Ile Asp Tyr Asp Val Glu 
                85                  90                  95      


Leu Gln Glu Leu Gln Ile Pro Gly Lys Ala Cys Val Asn Asn Thr Ile 
            100                 105                 110         


Val Trp Thr Asn Ser Ser Leu Asn Gln Asn Met Thr Asn Gly Thr Arg 
        115                 120                 125             


Cys Gly Leu Leu Asn Ile Glu Ser Glu Met Ile Lys Phe Ala Ser Tyr 
    130                 135                 140                 


Tyr Ala Gly Ile Ala Val Ala Val Leu Ile Thr Gly Tyr Ile Gln Ile 
145                 150                 155                 160 


Cys Phe Trp Val Ile Ala Ala Ala Arg Gln Ile Gln Lys Met Arg Lys 
                165                 170                 175     


Phe Tyr Phe Arg Arg Ile Met Arg Met Glu Ile Gly Trp Phe Asp Cys 
            180                 185                 190         


Asn Ser Val Gly Glu Leu Asn Thr Arg Phe Ser Asp Asp Ile Asn Lys 
        195                 200                 205             


Ile Asn Asp Ala Ile Ala Asp Gln Met Ala Leu Phe Ile Gln Arg Met 
    210                 215                 220                 


Thr Ser Thr Ile Cys Gly Phe Leu Leu Gly Phe Phe Arg Gly Trp Lys 
225                 230                 235                 240 


Leu Thr Leu Val Ile Ile Ser Val Ser Pro Leu Ile Gly Ile Gly Ala 
                245                 250                 255     


Ala Thr Ile Gly Leu Ser Val Ser Lys Phe Thr Asp Tyr Glu Leu Lys 
            260                 265                 270         


Ala Tyr Ala Lys Ala Gly Val Val Ala Asp Glu Val Ile Ser Ser Met 
        275                 280                 285             


Arg Thr Val Ala Ala Phe Gly Gly Glu Lys Arg Glu Val Glu Arg Tyr 
    290                 295                 300                 


Glu Lys Asn Leu Val Phe Ala Gln Arg Trp Gly Ile Arg Lys Gly Ile 
305                 310                 315                 320 


Val Met Gly Phe Phe Thr Gly Phe Val Trp Cys Leu Ile Phe Leu Cys 
                325                 330                 335     


Tyr Ala Leu Ala Phe Trp Tyr Gly Ser Thr Leu Val Leu Asp Glu Gly 
            340                 345                 350         


Glu Tyr Thr Pro Gly Thr Leu Val Gln Ile Phe Leu Ser Val Ile Val 
        355                 360                 365             


Gly Ala Leu Asn Leu Gly Asn Ala Ser Pro Cys Leu Glu Ala Phe Ala 
    370                 375                 380                 


Thr Gly Arg Ala Ala Ala Thr Ser Ile Phe Glu Thr Ile Asp Arg Lys 
385                 390                 395                 400 


Pro Ile Ile Asp Cys Met Ser Glu Asp Gly Tyr Lys Leu Asp Arg Ile 
                405                 410                 415     


Lys Gly Glu Ile Glu Phe His Asn Val Thr Phe His Tyr Pro Ser Arg 
            420                 425                 430         


Pro Glu Val Lys Ile Leu Asn Asp Leu Asn Met Val Ile Lys Pro Gly 
        435                 440                 445             


Glu Met Thr Ala Leu Val Gly Pro Ser Gly Ala Gly Lys Ser Thr Ala 
    450                 455                 460                 


Leu Gln Leu Ile Gln Arg Phe Tyr Asp Pro Cys Glu Gly Met Val Thr 
465                 470                 475                 480 


Val Asp Gly His Asp Ile Arg Ser Leu Asn Ile Gln Trp Leu Arg Asp 
                485                 490                 495     


Gln Ile Gly Ile Val Glu Gln Glu Pro Val Leu Phe Ser Thr Thr Ile 
            500                 505                 510         


Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asp Ala Thr Met Glu Asp Ile 
        515                 520                 525             


Val Gln Ala Ala Lys Glu Ala Asn Ala Tyr Asn Phe Ile Met Asp Leu 
    530                 535                 540                 


Pro Gln Gln Phe Asp Thr Leu Val Gly Glu Gly Gly Gly Gln Met Ser 
545                 550                 555                 560 


Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Arg Asn 
                565                 570                 575     


Pro Lys Ile Leu Leu Leu Asp Met Ala Thr Ser Ala Leu Asp Asn Glu 
            580                 585                 590         


Ser Glu Ala Met Val Gln Glu Val Leu Ser Lys Ile Gln His Gly His 
        595                 600                 605             


Thr Ile Ile Ser Val Ala His Arg Leu Ser Thr Val Arg Ala Ala Asp 
    610                 615                 620                 


Thr Ile Ile Gly Phe Glu His Gly Thr Ala Val Glu Arg Gly Thr His 
625                 630                 635                 640 


Glu Glu Leu Leu Glu Arg Lys Gly Val Tyr Phe Thr Leu Val Thr Leu 
                645                 650                 655     


Gln Ser Gln Gly Asn Gln Ala Leu Asn Glu Glu Asp Ile Lys Asp Ala 
            660                 665                 670         


Thr Glu Asp Asp Met Leu Ala Arg Thr Phe Ser Arg Gly Ser Tyr Gln 
        675                 680                 685             


Asp Ser Leu Arg Ala Ser Ile Arg Gln Arg Ser Lys Ser Gln Leu Ser 
    690                 695                 700                 


Tyr Leu Val His Glu Pro Pro Leu Ala Val Val Asp His Lys Ser Thr 
705                 710                 715                 720 


Tyr Glu Glu Asp Arg Lys Asp Lys Asp Ile Pro Val Gln Glu Glu Val 
                725                 730                 735     


Glu Pro Ala Pro Val Arg Arg Ile Leu Lys Phe Ser Ala Pro Glu Trp 
            740                 745                 750         


Pro Tyr Met Leu Val Gly Ser Val Gly Ala Ala Val Asn Gly Thr Val 
        755                 760                 765             


Thr Pro Leu Tyr Ala Phe Leu Phe Ser Gln Ile Leu Gly Thr Phe Ser 
    770                 775                 780                 


Ile Pro Asp Lys Glu Glu Gln Arg Ser Gln Ile Asn Gly Val Cys Leu 
785                 790                 795                 800 


Leu Phe Val Ala Met Gly Cys Val Ser Leu Phe Thr Gln Phe Leu Gln 
                805                 810                 815     


Gly Tyr Ala Phe Ala Lys Ser Gly Glu Leu Leu Thr Lys Arg Leu Arg 
            820                 825                 830         


Lys Phe Gly Phe Arg Ala Met Leu Gly Gln Asp Ile Ala Trp Phe Asp 
        835                 840                 845             


Asp Leu Arg Asn Ser Pro Gly Ala Leu Thr Thr Arg Leu Ala Thr Asp 
    850                 855                 860                 


Ala Ser Gln Val Gln Gly Ala Ala Gly Ser Gln Ile Gly Met Ile Val 
865                 870                 875                 880 


Asn Ser Phe Thr Asn Val Thr Val Ala Met Ile Ile Ala Phe Ser Phe 
                885                 890                 895     


Ser Trp Lys Leu Ser Leu Val Ile Leu Cys Phe Phe Pro Phe Leu Ala 
            900                 905                 910         


Leu Ser Gly Ala Thr Gln Thr Arg Met Leu Thr Gly Phe Ala Ser Arg 
        915                 920                 925             


Asp Lys Gln Ala Leu Glu Met Val Gly Gln Ile Thr Asn Glu Ala Leu 
    930                 935                 940                 


Ser Asn Ile Arg Thr Val Ala Gly Ile Gly Lys Glu Arg Arg Phe Ile 
945                 950                 955                 960 


Glu Ala Leu Glu Thr Glu Leu Glu Lys Pro Phe Lys Thr Ala Ile Gln 
                965                 970                 975     


Lys Ala Asn Ile Tyr Gly Phe Cys Phe Ala Phe Ala Gln Cys Ile Met 
            980                 985                 990         


Phe Ile Ala Asn Ser Ala Ser Tyr  Arg Tyr Gly Gly Tyr  Leu Ile Ser 
        995                 1000                 1005             


Asn Glu  Gly Leu His Phe Ser  Tyr Val Phe Arg Val  Ile Ser Ala 
    1010                 1015                 1020             


Val Val  Leu Ser Ala Thr Ala  Leu Gly Arg Ala Phe  Ser Tyr Thr 
    1025                 1030                 1035             


Pro Ser  Tyr Ala Lys Ala Lys  Ile Ser Ala Ala Arg  Phe Phe Gln 
    1040                 1045                 1050             


Leu Leu  Asp Arg Gln Pro Pro  Ile Ser Val Tyr Asn  Thr Ala Gly 
    1055                 1060                 1065             


Glu Lys  Trp Asp Asn Phe Gln  Gly Lys Ile Asp Phe  Val Asp Cys 
    1070                 1075                 1080             


Lys Phe  Thr Tyr Pro Ser Arg  Pro Asp Ser Gln Val  Leu Asn Gly 
    1085                 1090                 1095             


Leu Ser  Val Ser Ile Ser Pro  Gly Gln Thr Leu Ala  Phe Val Gly 
    1100                 1105                 1110             


Ser Ser  Gly Cys Gly Lys Ser  Thr Ser Ile Gln Leu  Leu Glu Arg 
    1115                 1120                 1125             


Phe Tyr  Asp Pro Asp Gln Gly  Lys Val Met Ile Asp  Gly His Asp 
    1130                 1135                 1140             


Ser Lys  Lys Val Asn Val Gln  Phe Leu Arg Ser Asn  Ile Gly Ile 
    1145                 1150                 1155             


Val Ser  Gln Glu Pro Val Leu  Phe Ala Cys Ser Ile  Met Asp Asn 
    1160                 1165                 1170             


Ile Lys  Tyr Gly Asp Asn Thr  Lys Glu Ile Pro Met  Glu Arg Val 
    1175                 1180                 1185             


Ile Ala  Ala Ala Lys Gln Ala  Gln Leu His Asp Phe  Val Met Ser 
    1190                 1195                 1200             


Leu Pro  Glu Lys Tyr Glu Thr  Asn Val Gly Ser Gln  Gly Ser Gln 
    1205                 1210                 1215             


Leu Ser  Arg Gly Glu Lys Gln  Arg Ile Ala Ile Ala  Arg Ala Ile 
    1220                 1225                 1230             


Val Arg  Asp Pro Lys Ile Leu  Leu Leu Asp Glu Ala  Thr Ser Ala 
    1235                 1240                 1245             


Leu Asp  Thr Glu Ser Glu Lys  Thr Val Gln Val Ala  Leu Asp Lys 
    1250                 1255                 1260             


Ala Arg  Glu Gly Arg Thr Cys  Ile Val Ile Ala His  Arg Leu Ser 
    1265                 1270                 1275             


Thr Ile  Gln Asn Ala Asp Ile  Ile Ala Val Met Ala  Gln Gly Val 
    1280                 1285                 1290             


Val Ile  Glu Lys Gly Thr His  Glu Glu Leu Met Ala  Gln Lys Gly 
    1295                 1300                 1305             


Ala Tyr  Tyr Lys Leu Val Thr  Thr Gly Ser Pro Ile  Ser 
    1310                 1315                 1320     


<210>  43
<211>  1280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB1__Homo_sapiens__NP_000918

<400>  43

Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 
1               5                   10                  15      


Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 
            20                  25                  30          


Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 
        35                  40                  45              


Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 
    50                  55                  60                  


Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 
65                  70                  75                  80  


Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 
                85                  90                  95      


Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 
            100                 105                 110         


Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 
        115                 120                 125             


Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 
    130                 135                 140                 


His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 
145                 150                 155                 160 


Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 
                165                 170                 175     


Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 
            180                 185                 190         


Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 
        195                 200                 205             


Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 
    210                 215                 220                 


Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 
225                 230                 235                 240 


Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 
                245                 250                 255     


Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 
            260                 265                 270         


Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 
        275                 280                 285             


Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 
    290                 295                 300                 


Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 
305                 310                 315                 320 


Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 
                325                 330                 335     


Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 
            340                 345                 350         


Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 
        355                 360                 365             


Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 
    370                 375                 380                 


Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 
385                 390                 395                 400 


Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 
                405                 410                 415     


Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 
            420                 425                 430         


Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 
        435                 440                 445             


Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 
    450                 455                 460                 


Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 
465                 470                 475                 480 


Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 
                485                 490                 495     


Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 
            500                 505                 510         


Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 
        515                 520                 525             


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 
    530                 535                 540                 


Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 
545                 550                 555                 560 


Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 
                565                 570                 575     


Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 
            580                 585                 590         


Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 
        595                 600                 605             


Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 
    610                 615                 620                 


Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 
625                 630                 635                 640 


Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 
                645                 650                 655     


Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 
            660                 665                 670         


Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 
        675                 680                 685             


Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 
    690                 695                 700                 


Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 
                725                 730                 735     


Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 
            740                 745                 750         


Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 
        755                 760                 765             


Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 
    770                 775                 780                 


Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 
785                 790                 795                 800 


Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 
                805                 810                 815     


Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 
            820                 825                 830         


Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 
        835                 840                 845             


Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 
    850                 855                 860                 


Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 
865                 870                 875                 880 


Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly Lys Ile 
                885                 890                 895     


Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 
            900                 905                 910         


Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 
        915                 920                 925             


Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 
    930                 935                 940                 


Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 
945                 950                 955                 960 


Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 
                965                 970                 975     


Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 
            980                 985                 990         


Ser Phe Ala Pro Asp Tyr Ala Lys  Ala Lys Ile Ser Ala  Ala His Ile 
        995                 1000                 1005             


Ile Met  Ile Ile Glu Lys Thr  Pro Leu Ile Asp Ser  Tyr Ser Thr 
    1010                 1015                 1020             


Glu Gly  Leu Met Pro Asn Thr  Leu Glu Gly Asn Val  Thr Phe Gly 
    1025                 1030                 1035             


Glu Val  Val Phe Asn Tyr Pro  Thr Arg Pro Asp Ile  Pro Val Leu 
    1040                 1045                 1050             


Gln Gly  Leu Ser Leu Glu Val  Lys Lys Gly Gln Thr  Leu Ala Leu 
    1055                 1060                 1065             


Val Gly  Ser Ser Gly Cys Gly  Lys Ser Thr Val Val  Gln Leu Leu 
    1070                 1075                 1080             


Glu Arg  Phe Tyr Asp Pro Leu  Ala Gly Lys Val Leu  Leu Asp Gly 
    1085                 1090                 1095             


Lys Glu  Ile Lys Arg Leu Asn  Val Gln Trp Leu Arg  Ala His Leu 
    1100                 1105                 1110             


Gly Ile  Val Ser Gln Glu Pro  Ile Leu Phe Asp Cys  Ser Ile Ala 
    1115                 1120                 1125             


Glu Asn  Ile Ala Tyr Gly Asp  Asn Ser Arg Val Val  Ser Gln Glu 
    1130                 1135                 1140             


Glu Ile  Val Arg Ala Ala Lys  Glu Ala Asn Ile His  Ala Phe Ile 
    1145                 1150                 1155             


Glu Ser  Leu Pro Asn Lys Tyr  Ser Thr Lys Val Gly  Asp Lys Gly 
    1160                 1165                 1170             


Thr Gln  Leu Ser Gly Gly Gln  Lys Gln Arg Ile Ala  Ile Ala Arg 
    1175                 1180                 1185             


Ala Leu  Val Arg Gln Pro His  Ile Leu Leu Leu Asp  Glu Ala Thr 
    1190                 1195                 1200             


Ser Ala  Leu Asp Thr Glu Ser  Glu Lys Val Val Gln  Glu Ala Leu 
    1205                 1210                 1215             


Asp Lys  Ala Arg Glu Gly Arg  Thr Cys Ile Val Ile  Ala His Arg 
    1220                 1225                 1230             


Leu Ser  Thr Ile Gln Asn Ala  Asp Leu Ile Val Val  Phe Gln Asn 
    1235                 1240                 1245             


Gly Arg  Val Lys Glu His Gly  Thr His Gln Gln Leu  Leu Ala Gln 
    1250                 1255                 1260             


Lys Gly  Ile Tyr Phe Ser Met  Val Ser Val Gln Ala  Gly Thr Lys 
    1265                 1270                 1275             


Arg Gln  
    1280 


<210>  44
<211>  1279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB4__Homo_sapiens__NP_000434

<400>  44

Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser 
1               5                   10                  15      


Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys 
            20                  25                  30          


Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr 
        35                  40                  45              


Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala 
    50                  55                  60                  


Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu 
65                  70                  75                  80  


Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val 
                85                  90                  95      


Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu 
            100                 105                 110         


Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu 
        115                 120                 125             


Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg 
    130                 135                 140                 


Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln 
145                 150                 155                 160 


Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg 
                165                 170                 175     


Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val 
            180                 185                 190         


Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val 
        195                 200                 205             


Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser 
    210                 215                 220                 


Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala 
225                 230                 235                 240 


Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala 
                245                 250                 255     


Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln 
            260                 265                 270         


Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu 
        275                 280                 285             


Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala 
    290                 295                 300                 


Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser 
305                 310                 315                 320 


Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val 
                325                 330                 335     


Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro 
            340                 345                 350         


Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe 
        355                 360                 365             


Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly 
    370                 375                 380                 


His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His 
385                 390                 395                 400 


Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn 
                405                 410                 415     


Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly 
            420                 425                 430         


Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro 
        435                 440                 445             


Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn 
    450                 455                 460                 


Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val 
465                 470                 475                 480 


Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn 
                485                 490                 495     


Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr 
            500                 505                 510         


Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu 
        515                 520                 525             


Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala 
    530                 535                 540                 


Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr 
545                 550                 555                 560 


Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp 
                565                 570                 575     


Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser 
            580                 585                 590         


Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile 
        595                 600                 605             


Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr 
    610                 615                 620                 


Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu 
625                 630                 635                 640 


Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn 
                645                 650                 655     


Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys 
            660                 665                 670         


Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu 
        675                 680                 685             


Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn 
    690                 695                 700                 


Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile 
                725                 730                 735     


Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn 
            740                 745                 750         


Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr 
        755                 760                 765             


Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr 
    770                 775                 780                 


Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met 
785                 790                 795                 800 


Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg 
                805                 810                 815     


Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu 
            820                 825                 830         


Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile 
        835                 840                 845             


Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val 
    850                 855                 860                 


Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly 
865                 870                 875                 880 


Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala 
                885                 890                 895     


Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu 
            900                 905                 910         


Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg 
        915                 920                 925             


Asn Ser Val Gln Lys Ala His Ile Tyr Gly Ile Thr Phe Ser Ile Ser 
    930                 935                 940                 


Gln Ala Phe Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly Ala 
945                 950                 955                 960 


Tyr Leu Ile Val Asn Gly His Met Arg Phe Arg Asp Val Ile Leu Val 
                965                 970                 975     


Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser Ser 
            980                 985                 990         


Phe Ala Pro Asp Tyr Ala Lys Ala  Lys Leu Ser Ala Ala  His Leu Phe 
        995                 1000                 1005             


Met Leu  Phe Glu Arg Gln Pro  Leu Ile Asp Ser Tyr  Ser Glu Glu 
    1010                 1015                 1020             


Gly Leu  Lys Pro Asp Lys Phe  Glu Gly Asn Ile Thr  Phe Asn Glu 
    1025                 1030                 1035             


Val Val  Phe Asn Tyr Pro Thr  Arg Ala Asn Val Pro  Val Leu Gln 
    1040                 1045                 1050             


Gly Leu  Ser Leu Glu Val Lys  Lys Gly Gln Thr Leu  Ala Leu Val 
    1055                 1060                 1065             


Gly Ser  Ser Gly Cys Gly Lys  Ser Thr Val Val Gln  Leu Leu Glu 
    1070                 1075                 1080             


Arg Phe  Tyr Asp Pro Leu Ala  Gly Thr Val Leu Leu  Asp Gly Gln 
    1085                 1090                 1095             


Glu Ala  Lys Lys Leu Asn Val  Gln Trp Leu Arg Ala  Gln Leu Gly 
    1100                 1105                 1110             


Ile Val  Ser Gln Glu Pro Ile  Leu Phe Asp Cys Ser  Ile Ala Glu 
    1115                 1120                 1125             


Asn Ile  Ala Tyr Gly Asp Asn  Ser Arg Val Val Ser  Gln Asp Glu 
    1130                 1135                 1140             


Ile Val  Ser Ala Ala Lys Ala  Ala Asn Ile His Pro  Phe Ile Glu 
    1145                 1150                 1155             


Thr Leu  Pro His Lys Tyr Glu  Thr Arg Val Gly Asp  Lys Gly Thr 
    1160                 1165                 1170             


Gln Leu  Ser Gly Gly Gln Lys  Gln Arg Ile Ala Ile  Ala Arg Ala 
    1175                 1180                 1185             


Leu Ile  Arg Gln Pro Gln Ile  Leu Leu Leu Asp Glu  Ala Thr Ser 
    1190                 1195                 1200             


Ala Leu  Asp Thr Glu Ser Glu  Lys Val Val Gln Glu  Ala Leu Asp 
    1205                 1210                 1215             


Lys Ala  Arg Glu Gly Arg Thr  Cys Ile Val Ile Ala  His Arg Leu 
    1220                 1225                 1230             


Ser Thr  Ile Gln Asn Ala Asp  Leu Ile Val Val Phe  Gln Asn Gly 
    1235                 1240                 1245             


Arg Val  Lys Glu His Gly Thr  His Gln Gln Leu Leu  Ala Gln Lys 
    1250                 1255                 1260             


Gly Ile  Tyr Phe Ser Met Val  Ser Val Gln Ala Gly  Thr Gln Asn 
    1265                 1270                 1275             


Leu 
    


<210>  45
<211>  1257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB5__Homo_sapiens__NP_001157413

<400>  45

Met Glu Asn Ser Glu Arg Ala Glu Glu Met Gln Glu Asn Tyr Gln Arg 
1               5                   10                  15      


Asn Gly Thr Ala Glu Glu Gln Pro Lys Leu Arg Lys Glu Ala Val Gly 
            20                  25                  30          


Ser Ile Glu Ile Phe Arg Phe Ala Asp Gly Leu Asp Ile Thr Leu Met 
        35                  40                  45              


Ile Leu Gly Ile Leu Ala Ser Leu Val Asn Gly Ala Cys Leu Pro Leu 
    50                  55                  60                  


Met Pro Leu Val Leu Gly Glu Met Ser Asp Asn Leu Ile Ser Gly Cys 
65                  70                  75                  80  


Leu Val Gln Thr Asn Thr Thr Asn Tyr Gln Asn Cys Thr Gln Ser Gln 
                85                  90                  95      


Glu Lys Leu Asn Glu Asp Met Thr Leu Leu Thr Leu Tyr Tyr Val Gly 
            100                 105                 110         


Ile Gly Val Ala Ala Leu Ile Phe Gly Tyr Ile Gln Ile Ser Leu Trp 
        115                 120                 125             


Ile Ile Thr Ala Ala Arg Gln Thr Lys Arg Ile Arg Lys Gln Phe Phe 
    130                 135                 140                 


His Ser Val Leu Ala Gln Asp Ile Gly Trp Phe Asp Ser Cys Asp Ile 
145                 150                 155                 160 


Gly Glu Leu Asn Thr Arg Met Thr Asp Asp Ile Asp Lys Ile Ser Asp 
                165                 170                 175     


Gly Ile Gly Asp Lys Ile Ala Leu Leu Phe Gln Asn Met Ser Thr Phe 
            180                 185                 190         


Ser Ile Gly Leu Ala Val Gly Leu Val Lys Gly Trp Lys Leu Thr Leu 
        195                 200                 205             


Val Thr Leu Ser Thr Ser Pro Leu Ile Met Ala Ser Ala Ala Ala Cys 
    210                 215                 220                 


Ser Arg Met Val Ile Ser Leu Thr Ser Lys Glu Leu Ser Ala Tyr Ser 
225                 230                 235                 240 


Lys Ala Gly Ala Val Ala Glu Glu Val Leu Ser Ser Ile Arg Thr Val 
                245                 250                 255     


Ile Ala Phe Arg Ala Gln Glu Lys Glu Leu Gln Arg Tyr Thr Gln Asn 
            260                 265                 270         


Leu Lys Asp Ala Lys Asp Phe Gly Ile Lys Arg Thr Ile Ala Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Ala Val Tyr Phe Phe Met Asn Gly Thr Tyr Gly Leu 
    290                 295                 300                 


Ala Phe Trp Tyr Gly Thr Ser Leu Ile Leu Asn Gly Glu Pro Gly Tyr 
305                 310                 315                 320 


Thr Ile Gly Thr Val Leu Ala Val Phe Phe Ser Val Ile His Ser Ser 
                325                 330                 335     


Tyr Cys Ile Gly Ala Ala Val Pro His Phe Glu Thr Phe Ala Ile Ala 
            340                 345                 350         


Arg Gly Ala Ala Phe His Ile Phe Gln Val Ile Asp Lys Lys Pro Ser 
        355                 360                 365             


Ile Asp Asn Phe Ser Thr Ala Gly Tyr Lys Pro Glu Ser Ile Glu Gly 
    370                 375                 380                 


Thr Val Glu Phe Lys Asn Val Ser Phe Asn Tyr Pro Ser Arg Pro Ser 
385                 390                 395                 400 


Ile Lys Ile Leu Lys Gly Leu Asn Leu Arg Ile Lys Ser Gly Glu Thr 
                405                 410                 415     


Val Ala Leu Val Gly Leu Asn Gly Ser Gly Lys Ser Thr Val Val Gln 
            420                 425                 430         


Leu Leu Gln Arg Leu Tyr Asp Pro Asp Asp Gly Phe Ile Met Val Asp 
        435                 440                 445             


Glu Asn Asp Ile Arg Ala Leu Asn Val Arg His Tyr Arg Asp His Ile 
    450                 455                 460                 


Gly Val Val Ser Gln Glu Pro Val Leu Phe Gly Thr Thr Ile Ser Asn 
465                 470                 475                 480 


Asn Ile Lys Tyr Gly Arg Asp Asp Val Thr Asp Glu Glu Met Glu Arg 
                485                 490                 495     


Ala Ala Arg Glu Ala Asn Ala Tyr Asp Phe Ile Met Glu Phe Pro Asn 
            500                 505                 510         


Lys Phe Asn Thr Leu Val Gly Glu Lys Gly Ala Gln Met Ser Gly Gly 
        515                 520                 525             


Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Arg Asn Pro Lys 
    530                 535                 540                 


Ile Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ser Glu Ser Lys 
545                 550                 555                 560 


Ser Ala Val Gln Ala Ala Leu Glu Lys Ala Ser Lys Gly Arg Thr Thr 
                565                 570                 575     


Ile Val Val Ala His Arg Leu Ser Thr Ile Arg Ser Ala Asp Leu Ile 
            580                 585                 590         


Val Thr Leu Lys Asp Gly Met Leu Ala Glu Lys Gly Ala His Ala Glu 
        595                 600                 605             


Leu Met Ala Lys Arg Gly Leu Tyr Tyr Ser Leu Val Met Ser Gln Asp 
    610                 615                 620                 


Ile Lys Lys Ala Asp Glu Gln Met Glu Ser Met Thr Tyr Ser Thr Glu 
625                 630                 635                 640 


Arg Lys Thr Asn Ser Leu Pro Leu His Ser Val Lys Ser Ile Lys Ser 
                645                 650                 655     


Asp Phe Ile Asp Lys Ala Glu Glu Ser Thr Gln Ser Lys Glu Ile Ser 
            660                 665                 670         


Leu Pro Glu Val Ser Leu Leu Lys Ile Leu Lys Leu Asn Lys Pro Glu 
        675                 680                 685             


Trp Pro Phe Val Val Leu Gly Thr Leu Ala Ser Val Leu Asn Gly Thr 
    690                 695                 700                 


Val His Pro Val Phe Ser Ile Ile Phe Ala Lys Ile Ile Thr Met Phe 
705                 710                 715                 720 


Gly Asn Asn Asp Lys Thr Thr Leu Lys His Asp Ala Glu Ile Tyr Ser 
                725                 730                 735     


Met Ile Phe Val Ile Leu Gly Val Ile Cys Phe Val Ser Tyr Phe Met 
            740                 745                 750         


Gln Gly Leu Phe Tyr Gly Arg Ala Gly Glu Ile Leu Thr Met Arg Leu 
        755                 760                 765             


Arg His Leu Ala Phe Lys Ala Met Leu Tyr Gln Asp Ile Ala Trp Phe 
    770                 775                 780                 


Asp Glu Lys Glu Asn Ser Thr Gly Gly Leu Thr Thr Ile Leu Ala Ile 
785                 790                 795                 800 


Asp Ile Ala Gln Ile Gln Gly Ala Thr Gly Ser Arg Ile Gly Val Leu 
                805                 810                 815     


Thr Gln Asn Ala Thr Asn Met Gly Leu Ser Val Ile Ile Ser Phe Ile 
            820                 825                 830         


Tyr Gly Trp Glu Met Thr Phe Leu Ile Leu Ser Ile Ala Pro Val Leu 
        835                 840                 845             


Ala Val Thr Gly Met Ile Glu Thr Ala Ala Met Thr Gly Phe Ala Asn 
    850                 855                 860                 


Lys Asp Lys Gln Glu Leu Lys His Ala Gly Lys Ile Ala Thr Glu Ala 
865                 870                 875                 880 


Leu Glu Asn Ile Arg Thr Ile Val Ser Leu Thr Arg Glu Lys Ala Phe 
                885                 890                 895     


Glu Gln Met Tyr Glu Glu Met Leu Gln Thr Gln His Arg Asn Thr Ser 
            900                 905                 910         


Lys Lys Ala Gln Ile Ile Gly Ser Cys Tyr Ala Phe Ser His Ala Phe 
        915                 920                 925             


Ile Tyr Phe Ala Tyr Ala Ala Gly Phe Arg Phe Gly Ala Tyr Leu Ile 
    930                 935                 940                 


Gln Ala Gly Arg Met Thr Pro Glu Gly Met Phe Ile Val Phe Thr Ala 
945                 950                 955                 960 


Ile Ala Tyr Gly Ala Met Ala Ile Gly Glu Thr Leu Val Leu Ala Pro 
                965                 970                 975     


Glu Tyr Ser Lys Ala Lys Ser Gly Ala Ala His Leu Phe Ala Leu Leu 
            980                 985                 990         


Glu Lys Lys Pro Asn Ile Asp Ser  Arg Ser Gln Glu Gly  Lys Lys Pro 
        995                 1000                 1005             


Asp Thr  Cys Glu Gly Asn Leu  Glu Phe Arg Glu Val  Ser Phe Phe 
    1010                 1015                 1020             


Tyr Pro  Cys Arg Pro Asp Val  Phe Ile Leu Arg Gly  Leu Ser Leu 
    1025                 1030                 1035             


Ser Ile  Glu Arg Gly Lys Thr  Val Ala Phe Val Gly  Ser Ser Gly 
    1040                 1045                 1050             


Cys Gly  Lys Ser Thr Ser Val  Gln Leu Leu Gln Arg  Leu Tyr Asp 
    1055                 1060                 1065             


Pro Val  Gln Gly Gln Val Leu  Phe Asp Gly Val Asp  Ala Lys Glu 
    1070                 1075                 1080             


Leu Asn  Val Gln Trp Leu Arg  Ser Gln Ile Ala Ile  Val Pro Gln 
    1085                 1090                 1095             


Glu Pro  Val Leu Phe Asn Cys  Ser Ile Ala Glu Asn  Ile Ala Tyr 
    1100                 1105                 1110             


Gly Asp  Asn Ser Arg Val Val  Pro Leu Asp Glu Ile  Lys Glu Ala 
    1115                 1120                 1125             


Ala Asn  Ala Ala Asn Ile His  Ser Phe Ile Glu Gly  Leu Pro Glu 
    1130                 1135                 1140             


Lys Tyr  Asn Thr Gln Val Gly  Leu Lys Gly Ala Gln  Leu Ser Gly 
    1145                 1150                 1155             


Gly Gln  Lys Gln Arg Leu Ala  Ile Ala Arg Ala Leu  Leu Gln Lys 
    1160                 1165                 1170             


Pro Lys  Ile Leu Leu Leu Asp  Glu Ala Thr Ser Ala  Leu Asp Asn 
    1175                 1180                 1185             


Asp Ser  Glu Lys Val Val Gln  His Ala Leu Asp Lys  Ala Arg Thr 
    1190                 1195                 1200             


Gly Arg  Thr Cys Leu Val Val  Thr His Arg Leu Ser  Ala Ile Gln 
    1205                 1210                 1215             


Asn Ala  Asp Leu Ile Val Val  Leu His Asn Gly Lys  Ile Lys Glu 
    1220                 1225                 1230             


Gln Gly  Thr His Gln Glu Leu  Leu Arg Asn Arg Asp  Ile Tyr Phe 
    1235                 1240                 1245             


Lys Leu  Val Asn Ala Gln Ser  Val Gln 
    1250                 1255         


<210>  46
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB6__Homo_sapiens__NP_005680

<400>  46

Met Val Thr Val Gly Asn Tyr Cys Glu Ala Glu Gly Pro Val Gly Pro 
1               5                   10                  15      


Ala Trp Met Gln Asp Gly Leu Ser Pro Cys Phe Phe Phe Thr Leu Val 
            20                  25                  30          


Pro Ser Thr Arg Met Ala Leu Gly Thr Leu Ala Leu Val Leu Ala Leu 
        35                  40                  45              


Pro Cys Arg Arg Arg Glu Arg Pro Ala Gly Ala Asp Ser Leu Ser Trp 
    50                  55                  60                  


Gly Ala Gly Pro Arg Ile Ser Pro Tyr Val Leu Gln Leu Leu Leu Ala 
65                  70                  75                  80  


Thr Leu Gln Ala Ala Leu Pro Leu Ala Gly Leu Ala Gly Arg Val Gly 
                85                  90                  95      


Thr Ala Arg Gly Ala Pro Leu Pro Ser Tyr Leu Leu Leu Ala Ser Val 
            100                 105                 110         


Leu Glu Ser Leu Ala Gly Ala Cys Gly Leu Trp Leu Leu Val Val Glu 
        115                 120                 125             


Arg Ser Gln Ala Arg Gln Arg Leu Ala Met Gly Ile Trp Ile Lys Phe 
    130                 135                 140                 


Arg His Ser Pro Gly Leu Leu Leu Leu Trp Thr Val Ala Phe Ala Ala 
145                 150                 155                 160 


Glu Asn Leu Ala Leu Val Ser Trp Asn Ser Pro Gln Trp Trp Trp Ala 
                165                 170                 175     


Arg Ala Asp Leu Gly Gln Gln Val Gln Phe Ser Leu Trp Val Leu Arg 
            180                 185                 190         


Tyr Val Val Ser Gly Gly Leu Phe Val Leu Gly Leu Trp Ala Pro Gly 
        195                 200                 205             


Leu Arg Pro Gln Ser Tyr Thr Leu Gln Val His Glu Glu Asp Gln Asp 
    210                 215                 220                 


Val Glu Arg Ser Gln Val Arg Ser Ala Ala Gln Gln Ser Thr Trp Arg 
225                 230                 235                 240 


Asp Phe Gly Arg Lys Leu Arg Leu Leu Ser Gly Tyr Leu Trp Pro Arg 
                245                 250                 255     


Gly Ser Pro Ala Leu Gln Leu Val Val Leu Ile Cys Leu Gly Leu Met 
            260                 265                 270         


Gly Leu Glu Arg Ala Leu Asn Val Leu Val Pro Ile Phe Tyr Arg Asn 
        275                 280                 285             


Ile Val Asn Leu Leu Thr Glu Lys Ala Pro Trp Asn Ser Leu Ala Trp 
    290                 295                 300                 


Thr Val Thr Ser Tyr Val Phe Leu Lys Phe Leu Gln Gly Gly Gly Thr 
305                 310                 315                 320 


Gly Ser Thr Gly Phe Val Ser Asn Leu Arg Thr Phe Leu Trp Ile Arg 
                325                 330                 335     


Val Gln Gln Phe Thr Ser Arg Arg Val Glu Leu Leu Ile Phe Ser His 
            340                 345                 350         


Leu His Glu Leu Ser Leu Arg Trp His Leu Gly Arg Arg Thr Gly Glu 
        355                 360                 365             


Val Leu Arg Ile Ala Asp Arg Gly Thr Ser Ser Val Thr Gly Leu Leu 
    370                 375                 380                 


Ser Tyr Leu Val Phe Asn Val Ile Pro Thr Leu Ala Asp Ile Ile Ile 
385                 390                 395                 400 


Gly Ile Ile Tyr Phe Ser Met Phe Phe Asn Ala Trp Phe Gly Leu Ile 
                405                 410                 415     


Val Phe Leu Cys Met Ser Leu Tyr Leu Thr Leu Thr Ile Val Val Thr 
            420                 425                 430         


Glu Trp Arg Thr Lys Phe Arg Arg Ala Met Asn Thr Gln Glu Asn Ala 
        435                 440                 445             


Thr Arg Ala Arg Ala Val Asp Ser Leu Leu Asn Phe Glu Thr Val Lys 
    450                 455                 460                 


Tyr Tyr Asn Ala Glu Ser Tyr Glu Val Glu Arg Tyr Arg Glu Ala Ile 
465                 470                 475                 480 


Ile Lys Tyr Gln Gly Leu Glu Trp Lys Ser Ser Ala Ser Leu Val Leu 
                485                 490                 495     


Leu Asn Gln Thr Gln Asn Leu Val Ile Gly Leu Gly Leu Leu Ala Gly 
            500                 505                 510         


Ser Leu Leu Cys Ala Tyr Phe Val Thr Glu Gln Lys Leu Gln Val Gly 
        515                 520                 525             


Asp Tyr Val Leu Phe Gly Thr Tyr Ile Ile Gln Leu Tyr Met Pro Leu 
    530                 535                 540                 


Asn Trp Phe Gly Thr Tyr Tyr Arg Met Ile Gln Thr Asn Phe Ile Asp 
545                 550                 555                 560 


Met Glu Asn Met Phe Asp Leu Leu Lys Glu Glu Thr Glu Val Lys Asp 
                565                 570                 575     


Leu Pro Gly Ala Gly Pro Leu Arg Phe Gln Lys Gly Arg Ile Glu Phe 
            580                 585                 590         


Glu Asn Val His Phe Ser Tyr Ala Asp Gly Arg Glu Thr Leu Gln Asp 
        595                 600                 605             


Val Ser Phe Thr Val Met Pro Gly Gln Thr Leu Ala Leu Val Gly Pro 
    610                 615                 620                 


Ser Gly Ala Gly Lys Ser Thr Ile Leu Arg Leu Leu Phe Arg Phe Tyr 
625                 630                 635                 640 


Asp Ile Ser Ser Gly Cys Ile Arg Ile Asp Gly Gln Asp Ile Ser Gln 
                645                 650                 655     


Val Thr Gln Ala Ser Leu Arg Ser His Ile Gly Val Val Pro Gln Asp 
            660                 665                 670         


Thr Val Leu Phe Asn Asp Thr Ile Ala Asp Asn Ile Arg Tyr Gly Arg 
        675                 680                 685             


Val Thr Ala Gly Asn Asp Glu Val Glu Ala Ala Ala Gln Ala Ala Gly 
    690                 695                 700                 


Ile His Asp Ala Ile Met Ala Phe Pro Glu Gly Tyr Arg Thr Gln Val 
705                 710                 715                 720 


Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Glu Lys Gln Arg Val Ala 
                725                 730                 735     


Ile Ala Arg Thr Ile Leu Lys Ala Pro Gly Ile Ile Leu Leu Asp Glu 
            740                 745                 750         


Ala Thr Ser Ala Leu Asp Thr Ser Asn Glu Arg Ala Ile Gln Ala Ser 
        755                 760                 765             


Leu Ala Lys Val Cys Ala Asn Arg Thr Thr Ile Val Val Ala His Arg 
    770                 775                 780                 


Leu Ser Thr Val Val Asn Ala Asp Gln Ile Leu Val Ile Lys Asp Gly 
785                 790                 795                 800 


Cys Ile Val Glu Arg Gly Arg His Glu Ala Leu Leu Ser Arg Gly Gly 
                805                 810                 815     


Val Tyr Ala Asp Met Trp Gln Leu Gln Gln Gly Gln Glu Glu Thr Ser 
            820                 825                 830         


Glu Asp Thr Lys Pro Gln Thr Met Glu Arg 
        835                 840         


<210>  47
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB7__Homo_sapiens__NP_001258625

<400>  47

Met Ala Leu Leu Ala Met His Ser Trp Arg Trp Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Glu Lys Arg Arg His Ser Ala Ile Leu Ile Arg Pro Leu Val 
            20                  25                  30          


Ser Val Ser Gly Ser Gly Pro Gln Trp Arg Pro His Gln Leu Gly Ala 
        35                  40                  45              


Leu Gly Thr Ala Arg Ala Tyr Gln Ile Pro Glu Ser Leu Lys Ser Ile 
    50                  55                  60                  


Thr Trp Gln Arg Leu Gly Lys Gly Asn Ser Gly Gln Phe Leu Asp Ala 
65                  70                  75                  80  


Ala Lys Ala Leu Gln Val Trp Pro Leu Ile Glu Lys Arg Thr Cys Trp 
                85                  90                  95      


His Gly His Ala Gly Gly Gly Leu His Thr Asp Pro Lys Glu Gly Leu 
            100                 105                 110         


Lys Asp Val Asp Thr Arg Lys Ile Ile Lys Ala Met Leu Ser Tyr Val 
        115                 120                 125             


Trp Pro Lys Asp Arg Pro Asp Leu Arg Ala Arg Val Ala Ile Ser Leu 
    130                 135                 140                 


Gly Phe Leu Gly Gly Ala Lys Ala Met Asn Ile Val Val Pro Phe Met 
145                 150                 155                 160 


Phe Lys Tyr Ala Val Asp Ser Leu Asn Gln Met Ser Gly Asn Met Leu 
                165                 170                 175     


Asn Leu Ser Asp Ala Pro Asn Thr Val Ala Thr Met Ala Thr Ala Val 
            180                 185                 190         


Leu Ile Gly Tyr Gly Val Ser Arg Ala Gly Ala Ala Phe Phe Asn Glu 
        195                 200                 205             


Val Arg Asn Ala Val Phe Gly Lys Val Ala Gln Asn Ser Ile Arg Arg 
    210                 215                 220                 


Ile Ala Lys Asn Val Phe Leu His Leu His Asn Leu Asp Leu Gly Phe 
225                 230                 235                 240 


His Leu Ser Arg Gln Thr Gly Ala Leu Ser Lys Ala Ile Asp Arg Gly 
                245                 250                 255     


Thr Arg Gly Ile Ser Phe Val Leu Ser Ala Leu Val Phe Asn Leu Leu 
            260                 265                 270         


Pro Ile Met Phe Glu Val Met Leu Val Ser Gly Val Leu Tyr Tyr Lys 
        275                 280                 285             


Cys Gly Ala Gln Phe Ala Leu Val Thr Leu Gly Thr Leu Gly Thr Tyr 
    290                 295                 300                 


Thr Ala Phe Thr Val Ala Val Thr Arg Trp Arg Thr Arg Phe Arg Ile 
305                 310                 315                 320 


Glu Met Asn Lys Ala Asp Asn Asp Ala Gly Asn Ala Ala Ile Asp Ser 
                325                 330                 335     


Leu Leu Asn Tyr Glu Thr Val Lys Tyr Phe Asn Asn Glu Arg Tyr Glu 
            340                 345                 350         


Ala Gln Arg Tyr Asp Gly Phe Leu Lys Thr Tyr Glu Thr Ala Ser Leu 
        355                 360                 365             


Lys Ser Thr Ser Thr Leu Ala Met Leu Asn Phe Gly Gln Ser Ala Ile 
    370                 375                 380                 


Phe Ser Val Gly Leu Thr Ala Ile Met Val Leu Ala Ser Gln Gly Ile 
385                 390                 395                 400 


Val Ala Gly Thr Leu Thr Val Gly Asp Leu Val Met Val Asn Gly Leu 
                405                 410                 415     


Leu Phe Gln Leu Ser Leu Pro Leu Asn Phe Leu Gly Thr Val Tyr Arg 
            420                 425                 430         


Glu Thr Arg Gln Ala Leu Ile Asp Met Asn Thr Leu Phe Thr Leu Leu 
        435                 440                 445             


Lys Val Asp Thr Gln Ile Lys Asp Lys Val Met Ala Ser Pro Leu Gln 
    450                 455                 460                 


Ile Thr Pro Gln Thr Ala Thr Val Ala Phe Asp Asn Val His Phe Glu 
465                 470                 475                 480 


Tyr Ile Glu Gly Gln Lys Val Leu Ser Gly Ile Ser Phe Glu Val Pro 
                485                 490                 495     


Ala Gly Lys Lys Val Ala Ile Val Gly Gly Ser Gly Ser Gly Lys Ser 
            500                 505                 510         


Thr Ile Val Arg Leu Leu Phe Arg Phe Tyr Glu Pro Gln Lys Gly Ser 
        515                 520                 525             


Ile Tyr Leu Ala Gly Gln Asn Ile Gln Asp Val Ser Leu Glu Ser Leu 
    530                 535                 540                 


Arg Arg Ala Val Gly Val Val Pro Gln Asp Ala Val Leu Phe His Asn 
545                 550                 555                 560 


Thr Ile Tyr Tyr Asn Leu Leu Tyr Gly Asn Ile Ser Ala Ser Pro Glu 
                565                 570                 575     


Glu Val Tyr Ala Val Ala Lys Leu Ala Gly Leu His Asp Ala Ile Leu 
            580                 585                 590         


Arg Met Pro His Gly Tyr Asp Thr Gln Val Gly Glu Arg Gly Leu Lys 
        595                 600                 605             


Leu Ser Gly Gly Glu Lys Gln Arg Val Ala Ile Ala Arg Ala Ile Leu 
    610                 615                 620                 


Lys Asp Pro Pro Val Ile Leu Tyr Asp Glu Ala Thr Ser Ser Leu Asp 
625                 630                 635                 640 


Ser Ile Thr Glu Glu Thr Ile Leu Gly Ala Met Lys Asp Val Val Lys 
                645                 650                 655     


His Arg Thr Ser Ile Phe Ile Ala His Arg Leu Ser Thr Val Val Asp 
            660                 665                 670         


Ala Asp Glu Ile Ile Val Leu Asp Gln Gly Lys Val Ala Glu Arg Gly 
        675                 680                 685             


Thr His His Gly Leu Leu Ala Asn Pro His Ser Ile Tyr Ser Glu Met 
    690                 695                 700                 


Trp His Thr Gln Ser Ser Arg Val Gln Asn His Asp Asn Pro Lys Trp 
705                 710                 715                 720 


Glu Ala Lys Lys Glu Asn Ile Ser Lys Glu Glu Glu Arg Lys Lys Leu 
                725                 730                 735     


Gln Glu Glu Ile Val Asn Ser Val Lys Gly Cys Gly Asn Cys Ser Cys 
            740                 745                 750         


<210>  48
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB8__Homo_sapiens__NP_001269220

<400>  48

Met Leu Val His Leu Phe Arg Val Gly Ile Arg Gly Gly Pro Phe Pro 
1               5                   10                  15      


Gly Arg Leu Leu Pro Pro Leu Arg Phe Gln Thr Phe Ser Ala Val Arg 
            20                  25                  30          


Asn Thr Trp Arg Asn Gly Lys Thr Gly Gln Leu His Lys Ala Glu Gly 
        35                  40                  45              


Glu Tyr Ser Asp Gly Tyr Arg Ser Ser Ser Leu Leu Arg Ala Val Ala 
    50                  55                  60                  


His Leu Arg Ser Gln Leu Trp Ala His Leu Pro Arg Ala Pro Leu Ala 
65                  70                  75                  80  


Pro Arg Trp Ser Pro Ser Ala Trp Cys Trp Val Gly Gly Ala Leu Leu 
                85                  90                  95      


Gly Pro Met Val Leu Ser Lys His Pro His Leu Cys Leu Val Ala Leu 
            100                 105                 110         


Cys Glu Ala Glu Glu Ala Pro Pro Ala Ser Ser Thr Pro His Val Val 
        115                 120                 125             


Gly Ser Arg Phe Asn Trp Lys Leu Phe Trp Gln Phe Leu His Pro His 
    130                 135                 140                 


Leu Leu Val Leu Gly Val Ala Val Val Leu Ala Leu Gly Ala Ala Leu 
145                 150                 155                 160 


Val Asn Val Gln Ile Pro Leu Leu Leu Gly Gln Leu Val Glu Val Val 
                165                 170                 175     


Ala Lys Tyr Thr Arg Asp His Val Gly Ser Phe Met Thr Glu Ser Gln 
            180                 185                 190         


Asn Leu Ser Thr His Leu Leu Ile Leu Tyr Gly Val Gln Gly Leu Leu 
        195                 200                 205             


Thr Phe Gly Tyr Leu Val Leu Leu Ser His Val Gly Glu Arg Met Ala 
    210                 215                 220                 


Val Asp Met Arg Arg Ala Leu Phe Ser Ser Leu Leu Arg Gln Asp Ile 
225                 230                 235                 240 


Thr Phe Phe Asp Ala Asn Lys Thr Gly Gln Leu Val Ser Arg Leu Thr 
                245                 250                 255     


Thr Asp Val Gln Glu Phe Lys Ser Ser Phe Lys Leu Val Ile Ser Gln 
            260                 265                 270         


Gly Leu Arg Ser Cys Thr Gln Val Ala Gly Cys Leu Val Ser Leu Ser 
        275                 280                 285             


Met Leu Ser Thr Arg Leu Thr Leu Leu Leu Met Val Ala Thr Pro Ala 
    290                 295                 300                 


Leu Met Gly Val Gly Thr Leu Met Gly Ser Gly Leu Arg Lys Leu Ser 
305                 310                 315                 320 


Arg Gln Cys Gln Glu Gln Ile Ala Arg Ala Met Gly Val Ala Asp Glu 
                325                 330                 335     


Ala Leu Gly Asn Val Arg Thr Val Arg Ala Phe Ala Met Glu Gln Arg 
            340                 345                 350         


Glu Glu Glu Arg Tyr Gly Ala Glu Leu Glu Ala Cys Arg Cys Arg Ala 
        355                 360                 365             


Glu Glu Leu Gly Arg Gly Ile Ala Leu Phe Gln Gly Leu Ser Asn Ile 
    370                 375                 380                 


Ala Phe Asn Cys Met Val Leu Gly Thr Leu Phe Ile Gly Gly Ser Leu 
385                 390                 395                 400 


Val Ala Gly Gln Gln Leu Thr Gly Gly Asp Leu Met Ser Phe Leu Val 
                405                 410                 415     


Ala Ser Gln Thr Val Gln Arg Ser Met Ala Asn Leu Ser Val Leu Phe 
            420                 425                 430         


Gly Gln Val Val Arg Gly Leu Ser Ala Gly Ala Arg Val Phe Glu Tyr 
        435                 440                 445             


Met Ala Leu Asn Pro Cys Ile Pro Leu Ser Gly Gly Cys Cys Val Pro 
    450                 455                 460                 


Lys Glu Gln Leu Arg Gly Ser Val Thr Phe Gln Asn Val Cys Phe Ser 
465                 470                 475                 480 


Tyr Pro Cys Arg Pro Gly Phe Glu Val Leu Lys Asp Phe Thr Leu Thr 
                485                 490                 495     


Leu Pro Pro Gly Lys Ile Val Ala Leu Val Gly Gln Ser Gly Gly Gly 
            500                 505                 510         


Lys Thr Thr Val Ala Ser Leu Leu Glu Arg Phe Tyr Asp Pro Thr Ala 
        515                 520                 525             


Gly Val Val Met Leu Asp Gly Arg Asp Leu Arg Thr Leu Asp Pro Ser 
    530                 535                 540                 


Trp Leu Arg Gly Gln Val Val Gly Phe Ile Ser Gln Glu Pro Val Leu 
545                 550                 555                 560 


Phe Gly Thr Thr Ile Met Glu Asn Ile Arg Phe Gly Lys Leu Glu Ala 
                565                 570                 575     


Ser Asp Glu Glu Val Tyr Thr Ala Ala Arg Glu Ala Asn Ala His Glu 
            580                 585                 590         


Phe Ile Thr Ser Phe Pro Glu Gly Tyr Asn Thr Val Val Gly Glu Arg 
        595                 600                 605             


Gly Thr Thr Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Arg 
    610                 615                 620                 


Ala Leu Ile Lys Gln Pro Thr Val Leu Ile Leu Asp Glu Ala Thr Ser 
625                 630                 635                 640 


Ala Leu Asp Ala Glu Ser Glu Arg Val Val Gln Glu Ala Leu Asp Arg 
                645                 650                 655     


Ala Ser Ala Gly Arg Thr Val Leu Val Ile Ala His Arg Leu Ser Thr 
            660                 665                 670         


Val Arg Gly Ala His Cys Ile Val Val Met Ala Asp Gly Arg Val Trp 
        675                 680                 685             


Glu Ala Gly Thr His Glu Glu Leu Leu Lys Lys Gly Gly Leu Tyr Ala 
    690                 695                 700                 


Glu Leu Ile Arg Arg Gln Ala Leu Asp Ala Pro Arg Thr Ala Ala Pro 
705                 710                 715                 720 


Pro Pro Lys Lys Pro Glu Gly Pro Arg Ser His Gln His Lys Ser 
                725                 730                 735 


<210>  49
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCB9__Homo_sapiens__NP_001229942

<400>  49

Met Arg Leu Trp Lys Ala Val Val Val Thr Leu Ala Phe Met Ser Val 
1               5                   10                  15      


Asp Ile Cys Val Thr Thr Ala Ile Tyr Val Phe Ser His Leu Asp Arg 
            20                  25                  30          


Ser Leu Leu Glu Asp Ile Arg His Phe Asn Ile Phe Asp Ser Val Leu 
        35                  40                  45              


Asp Leu Trp Ala Ala Cys Leu Tyr Arg Ser Cys Leu Leu Leu Gly Ala 
    50                  55                  60                  


Thr Ile Gly Val Ala Lys Asn Ser Ala Leu Gly Pro Arg Arg Leu Arg 
65                  70                  75                  80  


Ala Ser Trp Leu Val Ile Thr Leu Val Cys Leu Phe Val Gly Ile Tyr 
                85                  90                  95      


Ala Met Val Lys Leu Leu Leu Phe Ser Glu Val Arg Arg Pro Ile Arg 
            100                 105                 110         


Asp Pro Trp Phe Trp Ala Leu Phe Val Trp Thr Tyr Ile Ser Leu Gly 
        115                 120                 125             


Ala Ser Phe Leu Leu Trp Trp Leu Leu Ser Thr Val Arg Pro Gly Thr 
    130                 135                 140                 


Gln Ala Leu Glu Pro Gly Ala Ala Thr Glu Ala Glu Gly Phe Pro Gly 
145                 150                 155                 160 


Ser Gly Arg Pro Pro Pro Glu Gln Ala Ser Gly Ala Thr Leu Gln Lys 
                165                 170                 175     


Leu Leu Ser Tyr Thr Lys Pro Asp Val Ala Phe Leu Val Ala Ala Ser 
            180                 185                 190         


Phe Phe Leu Ile Val Ala Ala Leu Gly Glu Thr Phe Leu Pro Tyr Tyr 
        195                 200                 205             


Thr Gly Arg Ala Ile Asp Gly Ile Val Ile Gln Lys Ser Met Asp Gln 
    210                 215                 220                 


Phe Ser Thr Ala Val Val Ile Val Cys Leu Leu Ala Ile Gly Ser Ser 
225                 230                 235                 240 


Phe Ala Ala Gly Ile Arg Gly Gly Ile Phe Thr Leu Ile Phe Ala Arg 
                245                 250                 255     


Leu Asn Ile Arg Leu Arg Asn Cys Leu Phe Arg Ser Leu Val Ser Gln 
            260                 265                 270         


Glu Thr Ser Phe Phe Asp Glu Asn Arg Thr Gly Asp Leu Ile Ser Arg 
        275                 280                 285             


Leu Thr Ser Asp Thr Thr Met Val Ser Asp Leu Val Ser Gln Asn Ile 
    290                 295                 300                 


Asn Val Phe Leu Arg Asn Thr Val Lys Val Thr Gly Val Val Val Phe 
305                 310                 315                 320 


Met Phe Ser Leu Ser Trp Gln Leu Ser Leu Val Thr Phe Met Gly Phe 
                325                 330                 335     


Pro Ile Ile Met Met Val Ser Asn Ile Tyr Gly Lys Tyr Tyr Lys Arg 
            340                 345                 350         


Leu Ser Lys Glu Val Gln Asn Ala Leu Ala Arg Ala Ser Asn Thr Ala 
        355                 360                 365             


Glu Glu Thr Ile Ser Ala Met Lys Thr Val Arg Ser Phe Ala Asn Glu 
    370                 375                 380                 


Glu Glu Glu Ala Glu Val Tyr Leu Arg Lys Leu Gln Gln Val Tyr Lys 
385                 390                 395                 400 


Leu Asn Arg Lys Glu Ala Ala Ala Tyr Met Tyr Tyr Val Trp Gly Ser 
                405                 410                 415     


Gly Leu Thr Leu Leu Val Val Gln Val Ser Ile Leu Tyr Tyr Gly Gly 
            420                 425                 430         


His Leu Val Ile Ser Gly Gln Met Thr Ser Gly Asn Leu Ile Ala Phe 
        435                 440                 445             


Ile Ile Tyr Glu Phe Val Leu Gly Asp Cys Met Glu Asn Val Ser Phe 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Val Thr Ala Leu Val Gly Pro Ser Gly Ser 
465                 470                 475                 480 


Gly Lys Ser Ser Cys Val Asn Ile Leu Glu Asn Phe Tyr Pro Leu Glu 
                485                 490                 495     


Gly Gly Arg Val Leu Leu Asp Gly Lys Pro Ile Ser Ala Tyr Asp His 
            500                 505                 510         


Lys Tyr Leu His Arg Val Ile Ser Leu Val Ser Gln Glu Pro Val Leu 
        515                 520                 525             


Phe Ala Arg Ser Ile Thr Asp Asn Ile Ser Tyr Gly Leu Pro Thr Val 
    530                 535                 540                 


Pro Phe Glu Met Val Val Glu Ala Ala Gln Lys Ala Asn Ala His Gly 
545                 550                 555                 560 


Phe Ile Met Glu Leu Gln Asp Gly Tyr Ser Thr Glu Thr Gly Glu Lys 
                565                 570                 575     


Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Met Ala Arg 
            580                 585                 590         


Ala Leu Val Arg Asn Pro Pro Val Leu Ile Leu Asp Glu Ala Thr Ser 
        595                 600                 605             


Ala Leu Asp Ala Glu Ser Glu Tyr Leu Ile Gln Gln Ala Ile His Gly 
    610                 615                 620                 


Asn Leu Gln Lys His Thr Val Leu Ile Ile Ala His Arg Leu Ser Thr 
625                 630                 635                 640 


Val Glu His Ala His Leu Ile Val Val Leu Asp Lys Gly Arg Val Val 
                645                 650                 655     


Gln Gln Gly Thr His Gln Gln Leu Leu Ala Gln Gly Gly Leu Tyr Ala 
            660                 665                 670         


Lys Leu Val Gln Arg Gln Met Leu Gly Leu Gln Pro Ala Ala Asp Phe 
        675                 680                 685             


Thr Ala Gly His Asn Glu Pro Val Ala Asn Gly Ser His Lys Ala 
    690                 695                 700             


<210>  50
<211>  1492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC10__Homo_sapiens__NP_001185863

<400>  50

Met Glu Arg Leu Leu Ala Gln Leu Cys Gly Ser Ser Ala Ala Trp Pro 
1               5                   10                  15      


Leu Pro Leu Trp Glu Gly Asp Thr Thr Gly His Cys Phe Thr Gln Leu 
            20                  25                  30          


Val Leu Ser Ala Leu Pro His Ala Leu Leu Ala Val Leu Ser Ala Cys 
        35                  40                  45              


Tyr Leu Gly Thr Pro Arg Ser Pro Asp Tyr Ile Leu Pro Cys Ser Pro 
    50                  55                  60                  


Gly Trp Arg Leu Arg Leu Ala Ala Ser Phe Leu Leu Ser Val Phe Pro 
65                  70                  75                  80  


Leu Leu Asp Leu Leu Pro Val Ala Leu Pro Pro Gly Ala Gly Pro Gly 
                85                  90                  95      


Pro Ile Gly Leu Glu Val Leu Ala Gly Cys Val Ala Ala Val Ala Trp 
            100                 105                 110         


Ile Ser His Ser Leu Ala Leu Trp Val Leu Ala His Ser Pro His Gly 
        115                 120                 125             


His Ser Arg Gly Pro Leu Ala Leu Ala Leu Val Ala Leu Leu Pro Ala 
    130                 135                 140                 


Pro Ala Leu Val Leu Thr Val Leu Trp His Cys Gln Arg Gly Thr Leu 
145                 150                 155                 160 


Leu Pro Pro Leu Leu Pro Gly Pro Met Ala Arg Leu Cys Leu Leu Ile 
                165                 170                 175     


Leu Gln Leu Ala Ala Leu Leu Ala Tyr Ala Leu Gly Trp Ala Ala Pro 
            180                 185                 190         


Gly Gly Pro Arg Glu Pro Trp Ala Gln Glu Pro Leu Leu Pro Glu Asp 
        195                 200                 205             


Gln Glu Pro Glu Val Ala Glu Asp Gly Glu Ser Trp Leu Ser Arg Phe 
    210                 215                 220                 


Ser Tyr Ala Trp Leu Ala Pro Leu Leu Ala Arg Gly Ala Cys Gly Glu 
225                 230                 235                 240 


Leu Arg Gln Pro Gln Asp Ile Cys Arg Leu Pro His Arg Leu Gln Pro 
                245                 250                 255     


Thr Tyr Leu Ala Arg Val Phe Gln Ala His Trp Gln Glu Gly Ala Arg 
            260                 265                 270         


Leu Trp Arg Ala Leu Tyr Gly Ala Phe Gly Arg Cys Tyr Leu Ala Leu 
        275                 280                 285             


Gly Leu Leu Lys Leu Val Gly Thr Met Leu Gly Phe Ser Gly Pro Leu 
    290                 295                 300                 


Leu Leu Ser Leu Leu Val Gly Phe Leu Glu Glu Gly Gln Glu Pro Leu 
305                 310                 315                 320 


Ser His Gly Leu Leu Tyr Ala Leu Gly Leu Ala Gly Gly Ala Val Leu 
                325                 330                 335     


Gly Ala Val Leu Gln Asn Gln Tyr Gly Tyr Glu Val Tyr Lys Val Thr 
            340                 345                 350         


Leu Gln Ala Arg Gly Ala Val Leu Asn Ile Leu Tyr Cys Lys Ala Leu 
        355                 360                 365             


Gln Leu Gly Pro Ser Arg Pro Pro Thr Gly Glu Ala Leu Asn Leu Leu 
    370                 375                 380                 


Gly Thr Asp Ser Glu Arg Leu Leu Asn Phe Ala Gly Ser Phe His Glu 
385                 390                 395                 400 


Ala Trp Gly Leu Pro Leu Gln Leu Ala Ile Thr Leu Tyr Leu Leu Tyr 
                405                 410                 415     


Gln Gln Val Gly Val Ala Phe Val Gly Gly Leu Ile Leu Ala Leu Leu 
            420                 425                 430         


Leu Val Pro Val Asn Lys Val Ile Ala Thr Arg Ile Met Ala Ser Asn 
        435                 440                 445             


Gln Glu Met Leu Gln His Lys Asp Ala Arg Val Lys Leu Val Thr Glu 
    450                 455                 460                 


Leu Leu Ser Gly Ile Arg Val Ile Lys Phe Cys Gly Trp Glu Gln Ala 
465                 470                 475                 480 


Leu Gly Ala Arg Val Glu Ala Cys Arg Ala Arg Glu Leu Gly Arg Leu 
                485                 490                 495     


Arg Val Ile Lys Tyr Leu Asp Ala Ala Cys Val Tyr Leu Trp Ala Ala 
            500                 505                 510         


Leu Pro Val Val Ile Ser Ile Val Ile Phe Ile Thr Tyr Val Leu Met 
        515                 520                 525             


Gly His Gln Leu Thr Ala Thr Lys Val Phe Thr Ala Leu Ala Leu Val 
    530                 535                 540                 


Arg Met Leu Ile Leu Pro Leu Asn Asn Phe Pro Trp Val Ile Asn Gly 
545                 550                 555                 560 


Leu Leu Glu Ala Lys Val Ser Leu Asp Arg Ile Gln Leu Phe Leu Asp 
                565                 570                 575     


Leu Pro Asn His Asn Pro Gln Ala Tyr Tyr Ser Pro Asp Pro Pro Ala 
            580                 585                 590         


Glu Pro Ser Thr Val Leu Glu Leu His Gly Ala Leu Phe Ser Trp Asp 
        595                 600                 605             


Pro Val Gly Thr Ser Leu Glu Thr Phe Ile Ser His Leu Glu Val Lys 
    610                 615                 620                 


Lys Gly Met Leu Val Gly Ile Val Gly Lys Val Gly Cys Gly Lys Ser 
625                 630                 635                 640 


Ser Leu Leu Ala Ala Ile Ala Gly Glu Leu His Arg Leu Arg Gly His 
                645                 650                 655     


Val Ala Val Arg Gly Leu Ser Lys Gly Phe Gly Leu Ala Thr Gln Glu 
            660                 665                 670         


Pro Trp Ile Gln Phe Ala Thr Ile Arg Asp Asn Ile Leu Phe Gly Lys 
        675                 680                 685             


Thr Phe Asp Ala Gln Leu Tyr Lys Glu Val Leu Glu Ala Cys Ala Leu 
    690                 695                 700                 


Asn Asp Asp Leu Ser Ile Leu Pro Ala Gly Asp Gln Thr Glu Val Gly 
705                 710                 715                 720 


Glu Lys Gly Val Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ala Leu 
                725                 730                 735     


Ala Arg Ala Val Tyr Gln Glu Lys Glu Leu Tyr Leu Leu Asp Asp Pro 
            740                 745                 750         


Leu Ala Ala Val Asp Ala Asp Val Ala Asn His Leu Leu His Arg Cys 
        755                 760                 765             


Ile Leu Gly Met Leu Ser Tyr Thr Thr Arg Leu Leu Cys Thr His Arg 
    770                 775                 780                 


Thr Glu Tyr Leu Glu Arg Ala Asp Ala Val Leu Leu Met Glu Ala Gly 
785                 790                 795                 800 


Arg Leu Ile Arg Ala Gly Pro Pro Ser Glu Ile Leu Pro Leu Val Gln 
                805                 810                 815     


Ala Val Pro Lys Ala Trp Ala Glu Asn Gly Gln Glu Ser Asp Ser Ala 
            820                 825                 830         


Thr Ala Gln Ser Val Gln Asn Pro Glu Lys Thr Lys Glu Gly Leu Glu 
        835                 840                 845             


Glu Glu Gln Ser Thr Ser Gly Arg Leu Leu Gln Glu Glu Ser Lys Lys 
    850                 855                 860                 


Glu Gly Ala Val Ala Leu His Val Tyr Gln Ala Tyr Trp Lys Ala Val 
865                 870                 875                 880 


Gly Gln Gly Leu Ala Leu Ala Ile Leu Phe Ser Leu Leu Leu Met Gln 
                885                 890                 895     


Ala Thr Arg Asn Ala Ala Asp Trp Trp Leu Ser His Trp Ile Ser Gln 
            900                 905                 910         


Leu Lys Ala Glu Asn Ser Ser Gln Glu Ala Gln Pro Ser Thr Ser Pro 
        915                 920                 925             


Ala Ser Met Gly Leu Phe Ser Pro Gln Leu Leu Leu Phe Ser Pro Gly 
    930                 935                 940                 


Asn Leu Tyr Ile Pro Val Phe Pro Leu Pro Lys Ala Ala Pro Asn Gly 
945                 950                 955                 960 


Ser Ser Asp Ile Arg Phe Tyr Leu Thr Val Tyr Ala Thr Ile Ala Gly 
                965                 970                 975     


Val Asn Ser Leu Cys Thr Leu Leu Arg Ala Val Leu Phe Ala Ala Gly 
            980                 985                 990         


Thr Leu Gln Ala Ala Ala Thr Leu  His Arg Arg Leu Leu  His Arg Val 
        995                 1000                 1005             


Leu Met  Ala Pro Val Thr Phe  Phe Asn Ala Thr Pro  Thr Gly Arg 
    1010                 1015                 1020             


Ile Leu  Asn Arg Phe Ser Ser  Asp Val Ala Cys Ala  Asp Asp Ser 
    1025                 1030                 1035             


Leu Pro  Phe Ile Leu Asn Ile  Leu Leu Ala Asn Ala  Ala Gly Leu 
    1040                 1045                 1050             


Leu Gly  Leu Leu Ala Val Leu  Gly Ser Gly Leu Pro  Trp Leu Leu 
    1055                 1060                 1065             


Leu Leu  Leu Pro Pro Leu Ser  Ile Met Tyr Tyr His  Val Gln Arg 
    1070                 1075                 1080             


His Tyr  Arg Ala Ser Ser Arg  Glu Leu Arg Arg Leu  Gly Ser Leu 
    1085                 1090                 1095             


Thr Leu  Ser Pro Leu Tyr Ser  His Leu Ala Asp Thr  Leu Ala Gly 
    1100                 1105                 1110             


Leu Ser  Val Leu Arg Ala Thr  Gly Ala Thr Tyr Arg  Phe Glu Glu 
    1115                 1120                 1125             


Glu Asn  Leu Arg Leu Leu Glu  Leu Asn Gln Arg Cys  Gln Phe Ala 
    1130                 1135                 1140             


Thr Ser  Ala Thr Met Gln Trp  Leu Asp Ile Arg Leu  Gln Leu Met 
    1145                 1150                 1155             


Gly Ala  Ala Val Val Ser Ala  Ile Ala Gly Ile Ala  Leu Val Gln 
    1160                 1165                 1170             


His Gln  Gln Gly Leu Ala Asn  Pro Gly Leu Val Gly  Leu Ser Leu 
    1175                 1180                 1185             


Ser Tyr  Ala Leu Ser Leu Thr  Gly Leu Leu Ser Gly  Leu Val Ser 
    1190                 1195                 1200             


Ser Phe  Thr Gln Thr Glu Ala  Met Leu Val Ser Val  Glu Arg Leu 
    1205                 1210                 1215             


Glu Glu  Tyr Thr Cys Asp Leu  Pro Gln Glu Pro Gln  Gly Gln Pro 
    1220                 1225                 1230             


Leu Gln  Leu Gly Thr Gly Trp  Leu Thr Gln Gly Gly  Val Glu Phe 
    1235                 1240                 1245             


Gln Asp  Val Val Leu Ala Tyr  Arg Pro Gly Leu Pro  Asn Ala Leu 
    1250                 1255                 1260             


Asp Gly  Val Thr Phe Cys Val  Gln Pro Gly Glu Lys  Leu Gly Ile 
    1265                 1270                 1275             


Val Gly  Arg Thr Gly Ser Gly  Lys Ser Ser Leu Leu  Leu Val Leu 
    1280                 1285                 1290             


Phe Arg  Leu Leu Glu Pro Ser  Ser Gly Arg Val Leu  Leu Asp Gly 
    1295                 1300                 1305             


Val Asp  Thr Ser Gln Leu Glu  Leu Ala Gln Leu Arg  Ser Gln Leu 
    1310                 1315                 1320             


Ala Ile  Ile Pro Gln Glu Pro  Phe Leu Phe Ser Gly  Thr Val Arg 
    1325                 1330                 1335             


Glu Asn  Leu Asp Pro Gln Gly  Leu His Lys Asp Arg  Ala Leu Trp 
    1340                 1345                 1350             


Gln Ala  Leu Lys Gln Cys His  Leu Ser Glu Val Ile  Thr Ser Met 
    1355                 1360                 1365             


Gly Gly  Leu Asp Gly Glu Leu  Gly Glu Gly Gly Arg  Ser Leu Ser 
    1370                 1375                 1380             


Leu Gly  Gln Arg Gln Leu Leu  Cys Leu Ala Arg Ala  Leu Leu Thr 
    1385                 1390                 1395             


Asp Ala  Lys Ile Leu Cys Ile  Asp Glu Ala Thr Ala  Ser Val Asp 
    1400                 1405                 1410             


Gln Lys  Thr Asp Gln Leu Leu  Gln Gln Thr Ile Cys  Lys Arg Phe 
    1415                 1420                 1425             


Ala Asn  Lys Thr Val Leu Thr  Ile Ala His Arg Leu  Asn Thr Ile 
    1430                 1435                 1440             


Leu Asn  Ser Asp Arg Val Leu  Val Leu Gln Ala Gly  Arg Val Val 
    1445                 1450                 1455             


Glu Leu  Asp Ser Pro Ala Thr  Leu Arg Asn Gln Pro  His Ser Leu 
    1460                 1465                 1470             


Phe Gln  Gln Leu Leu Gln Ser  Ser Gln Gln Gly Val  Pro Ala Ser 
    1475                 1480                 1485             


Leu Gly  Gly Pro 
    1490         


<210>  51
<211>  1382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC11__Homo_sapiens__NP_115972

<400>  51

Met Thr Arg Lys Arg Thr Tyr Trp Val Pro Asn Ser Ser Gly Gly Leu 
1               5                   10                  15      


Val Asn Arg Gly Ile Asp Ile Gly Asp Asp Met Val Ser Gly Leu Ile 
            20                  25                  30          


Tyr Lys Thr Tyr Thr Leu Gln Asp Gly Pro Trp Ser Gln Gln Glu Arg 
        35                  40                  45              


Asn Pro Glu Ala Pro Gly Arg Ala Ala Val Pro Pro Trp Gly Lys Tyr 
    50                  55                  60                  


Asp Ala Ala Leu Arg Thr Met Ile Pro Phe Arg Pro Lys Pro Arg Phe 
65                  70                  75                  80  


Pro Ala Pro Gln Pro Leu Asp Asn Ala Gly Leu Phe Ser Tyr Leu Thr 
                85                  90                  95      


Val Ser Trp Leu Thr Pro Leu Met Ile Gln Ser Leu Arg Ser Arg Leu 
            100                 105                 110         


Asp Glu Asn Thr Ile Pro Pro Leu Ser Val His Asp Ala Ser Asp Lys 
        115                 120                 125             


Asn Val Gln Arg Leu His Arg Leu Trp Glu Glu Glu Val Ser Arg Arg 
    130                 135                 140                 


Gly Ile Glu Lys Ala Ser Val Leu Leu Val Met Leu Arg Phe Gln Arg 
145                 150                 155                 160 


Thr Arg Leu Ile Phe Asp Ala Leu Leu Gly Ile Cys Phe Cys Ile Ala 
                165                 170                 175     


Ser Val Leu Gly Pro Ile Leu Ile Ile Pro Lys Ile Leu Glu Tyr Ser 
            180                 185                 190         


Glu Glu Gln Leu Gly Asn Val Val His Gly Val Gly Leu Cys Phe Ala 
        195                 200                 205             


Leu Phe Leu Ser Glu Cys Val Lys Ser Leu Ser Phe Ser Ser Ser Trp 
    210                 215                 220                 


Ile Ile Asn Gln Arg Thr Ala Ile Arg Phe Arg Ala Ala Val Ser Ser 
225                 230                 235                 240 


Phe Ala Phe Glu Lys Leu Ile Gln Phe Lys Ser Val Ile His Ile Thr 
                245                 250                 255     


Ser Gly Glu Ala Ile Ser Phe Phe Thr Gly Asp Val Asn Tyr Leu Phe 
            260                 265                 270         


Glu Gly Val Cys Tyr Gly Pro Leu Val Leu Ile Thr Cys Ala Ser Leu 
        275                 280                 285             


Val Ile Cys Ser Ile Ser Ser Tyr Phe Ile Ile Gly Tyr Thr Ala Phe 
    290                 295                 300                 


Ile Ala Ile Leu Cys Tyr Leu Leu Val Phe Pro Leu Ala Val Phe Met 
305                 310                 315                 320 


Thr Arg Met Ala Val Lys Ala Gln His His Thr Ser Glu Val Ser Asp 
                325                 330                 335     


Gln Arg Ile Arg Val Thr Ser Glu Val Leu Thr Cys Ile Lys Leu Ile 
            340                 345                 350         


Lys Met Tyr Thr Trp Glu Lys Pro Phe Ala Lys Ile Ile Glu Asp Leu 
        355                 360                 365             


Arg Arg Lys Glu Arg Lys Leu Leu Glu Lys Cys Gly Leu Val Gln Ser 
    370                 375                 380                 


Leu Thr Ser Ile Thr Leu Phe Ile Ile Pro Thr Val Ala Thr Ala Val 
385                 390                 395                 400 


Trp Val Leu Ile His Thr Ser Leu Lys Leu Lys Leu Thr Ala Ser Met 
                405                 410                 415     


Ala Phe Ser Met Leu Ala Ser Leu Asn Leu Leu Arg Leu Ser Val Phe 
            420                 425                 430         


Phe Val Pro Ile Ala Val Lys Gly Leu Thr Asn Ser Lys Ser Ala Val 
        435                 440                 445             


Met Arg Phe Lys Lys Phe Phe Leu Gln Glu Ser Pro Val Phe Tyr Val 
    450                 455                 460                 


Gln Thr Leu Gln Asp Pro Ser Lys Ala Leu Val Phe Glu Glu Ala Thr 
465                 470                 475                 480 


Leu Ser Trp Gln Gln Thr Cys Pro Gly Ile Val Asn Gly Ala Leu Glu 
                485                 490                 495     


Leu Glu Arg Asn Gly His Ala Ser Glu Gly Met Thr Arg Pro Arg Asp 
            500                 505                 510         


Ala Leu Gly Pro Glu Glu Glu Gly Asn Ser Leu Gly Pro Glu Leu His 
        515                 520                 525             


Lys Ile Asn Leu Val Val Ser Lys Gly Met Met Leu Gly Val Cys Gly 
    530                 535                 540                 


Asn Thr Gly Ser Gly Lys Ser Ser Leu Leu Ser Ala Ile Leu Glu Glu 
545                 550                 555                 560 


Met His Leu Leu Glu Gly Ser Val Gly Val Gln Gly Ser Leu Ala Tyr 
                565                 570                 575     


Val Pro Gln Gln Ala Trp Ile Val Ser Gly Asn Ile Arg Glu Asn Ile 
            580                 585                 590         


Leu Met Gly Gly Ala Tyr Asp Lys Ala Arg Tyr Leu Gln Val Leu His 
        595                 600                 605             


Cys Cys Ser Leu Asn Arg Asp Leu Glu Leu Leu Pro Phe Gly Asp Met 
    610                 615                 620                 


Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Lys Gln 
625                 630                 635                 640 


Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Ile Tyr Leu 
                645                 650                 655     


Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile 
            660                 665                 670         


Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val Leu 
        675                 680                 685             


Val Thr His Gln Leu Gln Tyr Leu Glu Phe Cys Gly Gln Ile Ile Leu 
    690                 695                 700                 


Leu Glu Asn Gly Lys Ile Cys Glu Asn Gly Thr His Ser Glu Leu Met 
705                 710                 715                 720 


Gln Lys Lys Gly Lys Tyr Ala Gln Leu Ile Gln Lys Met His Lys Glu 
                725                 730                 735     


Ala Thr Ser Asp Met Leu Gln Asp Thr Ala Lys Ile Ala Glu Lys Pro 
            740                 745                 750         


Lys Val Glu Ser Gln Ala Leu Ala Thr Ser Leu Glu Glu Ser Leu Asn 
        755                 760                 765             


Gly Asn Ala Val Pro Glu His Gln Leu Thr Gln Glu Glu Glu Met Glu 
    770                 775                 780                 


Glu Gly Ser Leu Ser Trp Arg Val Tyr His His Tyr Ile Gln Ala Ala 
785                 790                 795                 800 


Gly Gly Tyr Met Val Ser Cys Ile Ile Phe Phe Phe Val Val Leu Ile 
                805                 810                 815     


Val Phe Leu Thr Ile Phe Ser Phe Trp Trp Leu Ser Tyr Trp Leu Glu 
            820                 825                 830         


Gln Gly Ser Gly Thr Asn Ser Ser Arg Glu Ser Asn Gly Thr Met Ala 
        835                 840                 845             


Asp Leu Gly Asn Ile Ala Asp Asn Pro Gln Leu Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Val Tyr Gly Leu Asn Ala Leu Leu Leu Ile Cys Val Gly Val Cys Ser 
865                 870                 875                 880 


Ser Gly Ile Phe Thr Lys Val Thr Arg Lys Ala Ser Thr Ala Leu His 
                885                 890                 895     


Asn Lys Leu Phe Asn Lys Val Phe Arg Cys Pro Met Ser Phe Phe Asp 
            900                 905                 910         


Thr Ile Pro Ile Gly Arg Leu Leu Asn Cys Phe Ala Gly Asp Leu Glu 
        915                 920                 925             


Gln Leu Asp Gln Leu Leu Pro Ile Phe Ser Glu Gln Phe Leu Val Leu 
    930                 935                 940                 


Ser Leu Met Val Ile Ala Val Leu Leu Ile Val Ser Val Leu Ser Pro 
945                 950                 955                 960 


Tyr Ile Leu Leu Met Gly Ala Ile Ile Met Val Ile Cys Phe Ile Tyr 
                965                 970                 975     


Tyr Met Met Phe Lys Lys Ala Ile Gly Val Phe Lys Arg Leu Glu Asn 
            980                 985                 990         


Tyr Ser Arg Ser Pro Leu Phe Ser  His Ile Leu Asn Ser  Leu Gln Gly 
        995                 1000                 1005             


Leu Ser  Ser Ile His Val Tyr  Gly Lys Thr Glu Asp  Phe Ile Ser 
    1010                 1015                 1020             


Gln Phe  Lys Arg Leu Thr Asp  Ala Gln Asn Asn Tyr  Leu Leu Leu 
    1025                 1030                 1035             


Phe Leu  Ser Ser Thr Arg Trp  Met Ala Leu Arg Leu  Glu Ile Met 
    1040                 1045                 1050             


Thr Asn  Leu Val Thr Leu Ala  Val Ala Leu Phe Val  Ala Phe Gly 
    1055                 1060                 1065             


Ile Ser  Ser Thr Pro Tyr Ser  Phe Lys Val Met Ala  Val Asn Ile 
    1070                 1075                 1080             


Val Leu  Gln Leu Ala Ser Ser  Phe Gln Ala Thr Ala  Arg Ile Gly 
    1085                 1090                 1095             


Leu Glu  Thr Glu Ala Gln Phe  Thr Ala Val Glu Arg  Ile Leu Gln 
    1100                 1105                 1110             


Tyr Met  Lys Met Cys Val Ser  Glu Ala Pro Leu His  Met Glu Gly 
    1115                 1120                 1125             


Thr Ser  Cys Pro Gln Gly Trp  Pro Gln His Gly Glu  Ile Ile Phe 
    1130                 1135                 1140             


Gln Asp  Tyr His Met Lys Tyr  Arg Asp Asn Thr Pro  Thr Val Leu 
    1145                 1150                 1155             


His Gly  Ile Asn Leu Thr Ile  Arg Gly His Glu Val  Val Gly Ile 
    1160                 1165                 1170             


Val Gly  Arg Thr Gly Ser Gly  Lys Ser Ser Leu Gly  Met Ala Leu 
    1175                 1180                 1185             


Phe Arg  Leu Val Glu Pro Met  Ala Gly Arg Ile Leu  Ile Asp Gly 
    1190                 1195                 1200             


Val Asp  Ile Cys Ser Ile Gly  Leu Glu Asp Leu Arg  Ser Lys Leu 
    1205                 1210                 1215             


Ser Val  Ile Pro Gln Asp Pro  Val Leu Leu Ser Gly  Thr Ile Arg 
    1220                 1225                 1230             


Phe Asn  Leu Asp Pro Phe Asp  Arg His Thr Asp Gln  Gln Ile Trp 
    1235                 1240                 1245             


Asp Ala  Leu Glu Arg Thr Phe  Leu Thr Lys Ala Ile  Ser Lys Phe 
    1250                 1255                 1260             


Pro Lys  Lys Leu His Thr Asp  Val Val Glu Asn Gly  Gly Asn Phe 
    1265                 1270                 1275             


Ser Val  Gly Glu Arg Gln Leu  Leu Cys Ile Ala Arg  Ala Val Leu 
    1280                 1285                 1290             


Arg Asn  Ser Lys Ile Ile Leu  Ile Asp Glu Ala Thr  Ala Ser Ile 
    1295                 1300                 1305             


Asp Met  Glu Thr Asp Thr Leu  Ile Gln Arg Thr Ile  Arg Glu Ala 
    1310                 1315                 1320             


Phe Gln  Gly Cys Thr Val Leu  Val Ile Ala His Arg  Val Thr Thr 
    1325                 1330                 1335             


Val Leu  Asn Cys Asp His Ile  Leu Val Met Gly Asn  Gly Lys Val 
    1340                 1345                 1350             


Val Glu  Phe Asp Arg Pro Glu  Val Leu Arg Lys Lys  Pro Gly Ser 
    1355                 1360                 1365             


Leu Phe  Ala Ala Leu Met Ala  Thr Ala Thr Ser Ser  Leu Arg 
    1370                 1375                 1380         


<210>  52
<211>  1359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC12__Homo_sapiens__NP_150229

<400>  52

Met Val Gly Glu Gly Pro Tyr Leu Ile Ser Asp Leu Asp Gln Arg Gly 
1               5                   10                  15      


Arg Arg Arg Ser Phe Ala Glu Arg Tyr Asp Pro Ser Leu Lys Thr Met 
            20                  25                  30          


Ile Pro Val Arg Pro Cys Ala Arg Leu Ala Pro Asn Pro Val Asp Asp 
        35                  40                  45              


Ala Gly Leu Leu Ser Phe Ala Thr Phe Ser Trp Leu Thr Pro Val Met 
    50                  55                  60                  


Val Lys Gly Tyr Arg Gln Arg Leu Thr Val Asp Thr Leu Pro Pro Leu 
65                  70                  75                  80  


Ser Thr Tyr Asp Ser Ser Asp Thr Asn Ala Lys Arg Phe Arg Val Leu 
                85                  90                  95      


Trp Asp Glu Glu Val Ala Arg Val Gly Pro Glu Lys Ala Ser Leu Ser 
            100                 105                 110         


His Val Val Trp Lys Phe Gln Arg Thr Arg Val Leu Met Asp Ile Val 
        115                 120                 125             


Ala Asn Ile Leu Cys Ile Ile Met Ala Ala Ile Gly Pro Val Ile Leu 
    130                 135                 140                 


Ile His Gln Ile Leu Gln Gln Thr Glu Arg Thr Ser Gly Lys Val Trp 
145                 150                 155                 160 


Val Gly Ile Gly Leu Cys Ile Ala Leu Phe Ala Thr Glu Phe Thr Lys 
                165                 170                 175     


Val Phe Phe Trp Ala Leu Ala Trp Ala Ile Asn Tyr Arg Thr Ala Ile 
            180                 185                 190         


Arg Leu Lys Val Ala Leu Ser Thr Leu Val Phe Glu Asn Leu Val Ser 
        195                 200                 205             


Phe Lys Thr Leu Thr His Ile Ser Val Gly Glu Val Leu Asn Ile Leu 
    210                 215                 220                 


Ser Ser Asp Ser Tyr Ser Leu Phe Glu Ala Ala Leu Phe Cys Pro Leu 
225                 230                 235                 240 


Pro Ala Thr Ile Pro Ile Leu Met Val Phe Cys Ala Ala Tyr Ala Phe 
                245                 250                 255     


Phe Ile Leu Gly Pro Thr Ala Leu Ile Gly Ile Ser Val Tyr Val Ile 
            260                 265                 270         


Phe Ile Pro Val Gln Met Phe Met Ala Lys Leu Asn Ser Ala Phe Arg 
        275                 280                 285             


Arg Ser Ala Ile Leu Val Thr Asp Lys Arg Val Gln Thr Met Asn Glu 
    290                 295                 300                 


Phe Leu Thr Cys Ile Arg Leu Ile Lys Met Tyr Ala Trp Glu Lys Ser 
305                 310                 315                 320 


Phe Thr Asn Thr Ile Gln Asp Ile Arg Arg Arg Glu Arg Lys Leu Leu 
                325                 330                 335     


Glu Lys Ala Gly Phe Val Gln Ser Gly Asn Ser Ala Leu Ala Pro Ile 
            340                 345                 350         


Val Ser Thr Ile Ala Ile Val Leu Thr Leu Ser Cys His Ile Leu Leu 
        355                 360                 365             


Arg Arg Lys Leu Thr Ala Pro Val Ala Phe Ser Val Ile Ala Met Phe 
    370                 375                 380                 


Asn Val Met Lys Phe Ser Ile Ala Ile Leu Pro Phe Ser Ile Lys Ala 
385                 390                 395                 400 


Met Ala Glu Ala Asn Val Ser Leu Arg Arg Met Lys Lys Ile Leu Ile 
                405                 410                 415     


Asp Lys Ser Pro Pro Ser Tyr Ile Thr Gln Pro Glu Asp Pro Asp Thr 
            420                 425                 430         


Val Leu Leu Leu Ala Asn Ala Thr Leu Thr Trp Glu His Glu Ala Ser 
        435                 440                 445             


Arg Lys Ser Thr Pro Lys Lys Leu Gln Asn Gln Lys Arg His Leu Cys 
    450                 455                 460                 


Lys Lys Gln Arg Ser Glu Ala Tyr Ser Glu Arg Ser Pro Pro Ala Lys 
465                 470                 475                 480 


Gly Ala Thr Gly Pro Glu Glu Gln Ser Asp Ser Leu Lys Ser Val Leu 
                485                 490                 495     


His Ser Ile Ser Phe Val Val Arg Lys Gly Lys Ile Leu Gly Ile Cys 
            500                 505                 510         


Gly Asn Val Gly Ser Gly Lys Ser Ser Leu Leu Ala Ala Leu Leu Gly 
        515                 520                 525             


Gln Met Gln Leu Gln Lys Gly Val Val Ala Val Asn Gly Thr Leu Ala 
    530                 535                 540                 


Tyr Val Ser Gln Gln Ala Trp Ile Phe His Gly Asn Val Arg Glu Asn 
545                 550                 555                 560 


Ile Leu Phe Gly Glu Lys Tyr Asp His Gln Arg Tyr Gln His Thr Val 
                565                 570                 575     


Arg Val Cys Gly Leu Gln Lys Asp Leu Ser Asn Leu Pro Tyr Gly Asp 
            580                 585                 590         


Leu Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Arg 
        595                 600                 605             


Gln Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Leu Tyr 
    610                 615                 620                 


Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His 
625                 630                 635                 640 


Val Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val 
                645                 650                 655     


Leu Val Thr His Gln Leu Gln Phe Leu Glu Ser Cys Asp Glu Val Ile 
            660                 665                 670         


Leu Leu Glu Asp Gly Glu Ile Cys Glu Lys Gly Thr His Lys Glu Leu 
        675                 680                 685             


Met Glu Glu Arg Gly Arg Tyr Ala Lys Leu Ile His Asn Leu Arg Gly 
    690                 695                 700                 


Leu Gln Phe Lys Asp Pro Glu His Leu Tyr Asn Ala Ala Met Val Glu 
705                 710                 715                 720 


Ala Phe Lys Glu Ser Pro Ala Glu Arg Glu Glu Asp Ala Gly Ile Ile 
                725                 730                 735     


Val Leu Ala Pro Gly Asn Glu Lys Asp Glu Gly Lys Glu Ser Glu Thr 
            740                 745                 750         


Gly Ser Glu Phe Val Asp Thr Lys Val Pro Glu His Gln Leu Ile Gln 
        755                 760                 765             


Thr Glu Ser Pro Gln Glu Gly Thr Val Thr Trp Lys Thr Tyr His Thr 
    770                 775                 780                 


Tyr Ile Lys Ala Ser Gly Gly Tyr Leu Leu Ser Leu Phe Thr Val Phe 
785                 790                 795                 800 


Leu Phe Leu Leu Met Ile Gly Ser Ala Ala Phe Ser Asn Trp Trp Leu 
                805                 810                 815     


Gly Leu Trp Leu Asp Lys Gly Ser Arg Met Thr Cys Gly Pro Gln Gly 
            820                 825                 830         


Asn Arg Thr Met Cys Glu Val Gly Ala Val Leu Ala Asp Ile Gly Gln 
        835                 840                 845             


His Val Tyr Gln Trp Val Tyr Thr Ala Ser Met Val Phe Met Leu Val 
    850                 855                 860                 


Phe Gly Val Thr Lys Gly Phe Val Phe Thr Lys Thr Thr Leu Met Ala 
865                 870                 875                 880 


Ser Ser Ser Leu His Asp Thr Val Phe Asp Lys Ile Leu Lys Ser Pro 
                885                 890                 895     


Met Ser Phe Phe Asp Thr Thr Pro Thr Gly Arg Leu Met Asn Arg Phe 
            900                 905                 910         


Ser Lys Asp Met Asp Glu Leu Asp Val Arg Leu Pro Phe His Ala Glu 
        915                 920                 925             


Asn Phe Leu Gln Gln Phe Phe Met Val Val Phe Ile Leu Val Ile Leu 
    930                 935                 940                 


Ala Ala Val Phe Pro Ala Val Leu Leu Val Val Ala Ser Leu Ala Val 
945                 950                 955                 960 


Gly Phe Phe Ile Leu Leu Arg Ile Phe His Arg Gly Val Gln Glu Leu 
                965                 970                 975     


Lys Lys Val Glu Asn Val Ser Arg Ser Pro Trp Phe Thr His Ile Thr 
            980                 985                 990         


Ser Ser Met Gln Gly Leu Gly Ile  Ile His Ala Tyr Gly  Lys Lys Glu 
        995                 1000                 1005             


Ser Cys  Ile Thr Tyr His Leu  Leu Tyr Phe Asn Cys  Ala Leu Arg 
    1010                 1015                 1020             


Trp Phe  Ala Leu Arg Met Asp  Val Leu Met Asn Ile  Leu Thr Phe 
    1025                 1030                 1035             


Thr Val  Ala Leu Leu Val Thr  Leu Ser Phe Ser Ser  Ile Ser Thr 
    1040                 1045                 1050             


Ser Ser  Lys Gly Leu Ser Leu  Ser Tyr Ile Ile Gln  Leu Ser Gly 
    1055                 1060                 1065             


Leu Leu  Gln Val Cys Val Arg  Thr Gly Thr Glu Thr  Gln Ala Lys 
    1070                 1075                 1080             


Phe Thr  Ser Val Glu Leu Leu  Arg Glu Tyr Ile Ser  Thr Cys Val 
    1085                 1090                 1095             


Pro Glu  Cys Thr His Pro Leu  Lys Val Gly Thr Cys  Pro Lys Asp 
    1100                 1105                 1110             


Trp Pro  Ser Arg Gly Glu Ile  Thr Phe Arg Asp Tyr  Gln Met Arg 
    1115                 1120                 1125             


Tyr Arg  Asp Asn Thr Pro Leu  Val Leu Asp Ser Leu  Asn Leu Asn 
    1130                 1135                 1140             


Ile Gln  Ser Gly Gln Thr Val  Gly Ile Val Gly Arg  Thr Gly Ser 
    1145                 1150                 1155             


Gly Lys  Ser Ser Leu Gly Met  Ala Leu Phe Arg Leu  Val Glu Pro 
    1160                 1165                 1170             


Ala Ser  Gly Thr Ile Phe Ile  Asp Glu Val Asp Ile  Cys Ile Leu 
    1175                 1180                 1185             


Ser Leu  Glu Asp Leu Arg Thr  Lys Leu Thr Val Ile  Pro Gln Asp 
    1190                 1195                 1200             


Pro Val  Leu Phe Val Gly Thr  Val Arg Tyr Asn Leu  Asp Pro Phe 
    1205                 1210                 1215             


Glu Ser  His Thr Asp Glu Met  Leu Trp Gln Val Leu  Glu Arg Thr 
    1220                 1225                 1230             


Phe Met  Arg Asp Thr Ile Met  Lys Leu Pro Glu Lys  Leu Gln Ala 
    1235                 1240                 1245             


Glu Val  Thr Glu Asn Gly Glu  Asn Phe Ser Val Gly  Glu Arg Gln 
    1250                 1255                 1260             


Leu Leu  Cys Val Ala Arg Ala  Leu Leu Arg Asn Ser  Lys Ile Ile 
    1265                 1270                 1275             


Leu Leu  Asp Glu Ala Thr Ala  Ser Met Asp Ser Lys  Thr Asp Thr 
    1280                 1285                 1290             


Leu Val  Gln Asn Thr Ile Lys  Asp Ala Phe Lys Gly  Cys Thr Val 
    1295                 1300                 1305             


Leu Thr  Ile Ala His Arg Leu  Asn Thr Val Leu Asn  Cys Asp His 
    1310                 1315                 1320             


Val Leu  Val Met Glu Asn Gly  Lys Val Ile Glu Phe  Asp Lys Pro 
    1325                 1330                 1335             


Glu Val  Leu Ala Glu Lys Pro  Asp Ser Ala Phe Ala  Met Leu Leu 
    1340                 1345                 1350             


Ala Ala  Glu Val Arg Leu 
    1355                 


<210>  53
<211>  1531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC1__Homo_sapiens__NP_004987

<400>  53

Met Ala Leu Arg Gly Phe Cys Ser Ala Asp Gly Ser Asp Pro Leu Trp 
1               5                   10                  15      


Asp Trp Asn Val Thr Trp Asn Thr Ser Asn Pro Asp Phe Thr Lys Cys 
            20                  25                  30          


Phe Gln Asn Thr Val Leu Val Trp Val Pro Cys Phe Tyr Leu Trp Ala 
        35                  40                  45              


Cys Phe Pro Phe Tyr Phe Leu Tyr Leu Ser Arg His Asp Arg Gly Tyr 
    50                  55                  60                  


Ile Gln Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu 
65                  70                  75                  80  


Leu Trp Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg 
                85                  90                  95      


Ser Arg Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu 
            100                 105                 110         


Leu Gly Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg 
        115                 120                 125             


Arg Lys Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val 
    130                 135                 140                 


Ala Leu Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala 
145                 150                 155                 160 


Leu Lys Glu Asp Ala Gln Val Asp Leu Phe Arg Asp Ile Thr Phe Tyr 
                165                 170                 175     


Val Tyr Phe Ser Leu Leu Leu Ile Gln Leu Val Leu Ser Cys Phe Ser 
            180                 185                 190         


Asp Arg Ser Pro Leu Phe Ser Glu Thr Ile His Asp Pro Asn Pro Cys 
        195                 200                 205             


Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr Phe Trp Trp Ile 
    210                 215                 220                 


Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu Glu Gly Ser Asp 
225                 230                 235                 240 


Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln Val Val Pro Val 
                245                 250                 255     


Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr Arg Lys Gln Pro 
            260                 265                 270         


Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln Pro Lys Glu Ser 
        275                 280                 285             


Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu Ile Val Lys Ser 
    290                 295                 300                 


Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val Leu Tyr Lys Thr 
305                 310                 315                 320 


Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys Ala Ile His Asp 
                325                 330                 335     


Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu Leu Ile Lys Phe 
            340                 345                 350         


Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr Phe Tyr Thr Val 
        355                 360                 365             


Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val Leu His Gln Tyr 
    370                 375                 380                 


Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys Thr Ala Val Ile 
385                 390                 395                 400 


Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Ala Arg Lys 
                405                 410                 415     


Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp Ala Gln 
            420                 425                 430         


Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile Trp Ser Ala Pro 
        435                 440                 445             


Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu Asn Leu Gly Pro 
    450                 455                 460                 


Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met Val Pro Val Asn 
465                 470                 475                 480 


Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val Ala His Met Lys 
                485                 490                 495     


Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile Leu Asn Gly Ile 
            500                 505                 510         


Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe Lys Asp Lys Val 
        515                 520                 525             


Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys Lys Ser Ala Tyr 
    530                 535                 540                 


Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr Pro Phe Leu Val 
545                 550                 555                 560 


Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp Glu Asn Asn Ile 
                565                 570                 575     


Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu Phe Asn Ile Leu 
            580                 585                 590         


Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser Ser Ile Val Gln 
        595                 600                 605             


Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu Ser His Glu Glu 
    610                 615                 620                 


Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys Asp Gly Gly Gly 
625                 630                 635                 640 


Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr Trp Ala Arg Ser 
                645                 650                 655     


Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile Pro Glu Gly Ala 
            660                 665                 670         


Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu 
        675                 680                 685             


Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly His Val Ala Ile 
    690                 695                 700                 


Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp Ile Gln Asn Asp 
705                 710                 715                 720 


Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu Glu Glu Pro Tyr 
                725                 730                 735     


Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro Asp Leu Glu Ile 
            740                 745                 750         


Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys Gly Val Asn Leu 
        755                 760                 765             


Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala Val Tyr Ser 
    770                 775                 780                 


Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser Ala Val Asp Ala 
785                 790                 795                 800 


His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly Pro Lys Gly Met 
                805                 810                 815     


Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser Met Ser Tyr Leu 
            820                 825                 830         


Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly Lys Ile Ser Glu 
        835                 840                 845             


Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly Ala Phe Ala Glu 
    850                 855                 860                 


Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln Asp Ala Glu Glu 
865                 870                 875                 880 


Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu Ala Lys Gln Met 
                885                 890                 895     


Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys Gln Leu Gln Arg 
            900                 905                 910         


Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile Ser Arg His His 
        915                 920                 925             


Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys Lys Glu Glu Thr 
    930                 935                 940                 


Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly Gln Val Lys Leu 
945                 950                 955                 960 


Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu Phe Ile Ser Phe 
                965                 970                 975     


Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser Ala Leu Ala Ser 
            980                 985                 990         


Asn Tyr Trp Leu Ser Leu Trp Thr  Asp Asp Pro Ile Val  Asn Gly Thr 
        995                 1000                 1005             


Gln Glu  His Thr Lys Val Arg  Leu Ser Val Tyr Gly  Ala Leu Gly 
    1010                 1015                 1020             


Ile Ser  Gln Gly Ile Ala Val  Phe Gly Tyr Ser Met  Ala Val Ser 
    1025                 1030                 1035             


Ile Gly  Gly Ile Leu Ala Ser  Arg Cys Leu His Val  Asp Leu Leu 
    1040                 1045                 1050             


His Ser  Ile Leu Arg Ser Pro  Met Ser Phe Phe Glu  Arg Thr Pro 
    1055                 1060                 1065             


Ser Gly  Asn Leu Val Asn Arg  Phe Ser Lys Glu Leu  Asp Thr Val 
    1070                 1075                 1080             


Asp Ser  Met Ile Pro Glu Val  Ile Lys Met Phe Met  Gly Ser Leu 
    1085                 1090                 1095             


Phe Asn  Val Ile Gly Ala Cys  Ile Val Ile Leu Leu  Ala Thr Pro 
    1100                 1105                 1110             


Ile Ala  Ala Ile Ile Ile Pro  Pro Leu Gly Leu Ile  Tyr Phe Phe 
    1115                 1120                 1125             


Val Gln  Arg Phe Tyr Val Ala  Ser Ser Arg Gln Leu  Lys Arg Leu 
    1130                 1135                 1140             


Glu Ser  Val Ser Arg Ser Pro  Val Tyr Ser His Phe  Asn Glu Thr 
    1145                 1150                 1155             


Leu Leu  Gly Val Ser Val Ile  Arg Ala Phe Glu Glu  Gln Glu Arg 
    1160                 1165                 1170             


Phe Ile  His Gln Ser Asp Leu  Lys Val Asp Glu Asn  Gln Lys Ala 
    1175                 1180                 1185             


Tyr Tyr  Pro Ser Ile Val Ala  Asn Arg Trp Leu Ala  Val Arg Leu 
    1190                 1195                 1200             


Glu Cys  Val Gly Asn Cys Ile  Val Leu Phe Ala Ala  Leu Phe Ala 
    1205                 1210                 1215             


Val Ile  Ser Arg His Ser Leu  Ser Ala Gly Leu Val  Gly Leu Ser 
    1220                 1225                 1230             


Val Ser  Tyr Ser Leu Gln Val  Thr Thr Tyr Leu Asn  Trp Leu Val 
    1235                 1240                 1245             


Arg Met  Ser Ser Glu Met Glu  Thr Asn Ile Val Ala  Val Glu Arg 
    1250                 1255                 1260             


Leu Lys  Glu Tyr Ser Glu Thr  Glu Lys Glu Ala Pro  Trp Gln Ile 
    1265                 1270                 1275             


Gln Glu  Thr Ala Pro Pro Ser  Ser Trp Pro Gln Val  Gly Arg Val 
    1280                 1285                 1290             


Glu Phe  Arg Asn Tyr Cys Leu  Arg Tyr Arg Glu Asp  Leu Asp Phe 
    1295                 1300                 1305             


Val Leu  Arg His Ile Asn Val  Thr Ile Asn Gly Gly  Glu Lys Val 
    1310                 1315                 1320             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Ser  Leu Thr Leu 
    1325                 1330                 1335             


Gly Leu  Phe Arg Ile Asn Glu  Ser Ala Glu Gly Glu  Ile Ile Ile 
    1340                 1345                 1350             


Asp Gly  Ile Asn Ile Ala Lys  Ile Gly Leu His Asp  Leu Arg Phe 
    1355                 1360                 1365             


Lys Ile  Thr Ile Ile Pro Gln  Asp Pro Val Leu Phe  Ser Gly Ser 
    1370                 1375                 1380             


Leu Arg  Met Asn Leu Asp Pro  Phe Ser Gln Tyr Ser  Asp Glu Glu 
    1385                 1390                 1395             


Val Trp  Thr Ser Leu Glu Leu  Ala His Leu Lys Asp  Phe Val Ser 
    1400                 1405                 1410             


Ala Leu  Pro Asp Lys Leu Asp  His Glu Cys Ala Glu  Gly Gly Glu 
    1415                 1420                 1425             


Asn Leu  Ser Val Gly Gln Arg  Gln Leu Val Cys Leu  Ala Arg Ala 
    1430                 1435                 1440             


Leu Leu  Arg Lys Thr Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala 
    1445                 1450                 1455             


Ala Val  Asp Leu Glu Thr Asp  Asp Leu Ile Gln Ser  Thr Ile Arg 
    1460                 1465                 1470             


Thr Gln  Phe Glu Asp Cys Thr  Val Leu Thr Ile Ala  His Arg Leu 
    1475                 1480                 1485             


Asn Thr  Ile Met Asp Tyr Thr  Arg Val Ile Val Leu  Asp Lys Gly 
    1490                 1495                 1500             


Glu Ile  Gln Glu Tyr Gly Ala  Pro Ser Asp Leu Leu  Gln Gln Arg 
    1505                 1510                 1515             


Gly Leu  Phe Tyr Ser Met Ala  Lys Asp Ala Gly Leu  Val 
    1520                 1525                 1530     


<210>  54
<211>  1545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC2__Homo_sapiens__NP_000383

<400>  54

Met Leu Glu Lys Phe Cys Asn Ser Thr Phe Trp Asn Ser Ser Phe Leu 
1               5                   10                  15      


Asp Ser Pro Glu Ala Asp Leu Pro Leu Cys Phe Glu Gln Thr Val Leu 
            20                  25                  30          


Val Trp Ile Pro Leu Gly Phe Leu Trp Leu Leu Ala Pro Trp Gln Leu 
        35                  40                  45              


Leu His Val Tyr Lys Ser Arg Thr Lys Arg Ser Ser Thr Thr Lys Leu 
    50                  55                  60                  


Tyr Leu Ala Lys Gln Val Phe Val Gly Phe Leu Leu Ile Leu Ala Ala 
65                  70                  75                  80  


Ile Glu Leu Ala Leu Val Leu Thr Glu Asp Ser Gly Gln Ala Thr Val 
                85                  90                  95      


Pro Ala Val Arg Tyr Thr Asn Pro Ser Leu Tyr Leu Gly Thr Trp Leu 
            100                 105                 110         


Leu Val Leu Leu Ile Gln Tyr Ser Arg Gln Trp Cys Val Gln Lys Asn 
        115                 120                 125             


Ser Trp Phe Leu Ser Leu Phe Trp Ile Leu Ser Ile Leu Cys Gly Thr 
    130                 135                 140                 


Phe Gln Phe Gln Thr Leu Ile Arg Thr Leu Leu Gln Gly Asp Asn Ser 
145                 150                 155                 160 


Asn Leu Ala Tyr Ser Cys Leu Phe Phe Ile Ser Tyr Gly Phe Gln Ile 
                165                 170                 175     


Leu Ile Leu Ile Phe Ser Ala Phe Ser Glu Asn Asn Glu Ser Ser Asn 
            180                 185                 190         


Asn Pro Ser Ser Ile Ala Ser Phe Leu Ser Ser Ile Thr Tyr Ser Trp 
        195                 200                 205             


Tyr Asp Ser Ile Ile Leu Lys Gly Tyr Lys Arg Pro Leu Thr Leu Glu 
    210                 215                 220                 


Asp Val Trp Glu Val Asp Glu Glu Met Lys Thr Lys Thr Leu Val Ser 
225                 230                 235                 240 


Lys Phe Glu Thr His Met Lys Arg Glu Leu Gln Lys Ala Arg Arg Ala 
                245                 250                 255     


Leu Gln Arg Arg Gln Glu Lys Ser Ser Gln Gln Asn Ser Gly Ala Arg 
            260                 265                 270         


Leu Pro Gly Leu Asn Lys Asn Gln Ser Gln Ser Gln Asp Ala Leu Val 
        275                 280                 285             


Leu Glu Asp Val Glu Lys Lys Lys Lys Lys Ser Gly Thr Lys Lys Asp 
    290                 295                 300                 


Val Pro Lys Ser Trp Leu Met Lys Ala Leu Phe Lys Thr Phe Tyr Met 
305                 310                 315                 320 


Val Leu Leu Lys Ser Phe Leu Leu Lys Leu Val Asn Asp Ile Phe Thr 
                325                 330                 335     


Phe Val Ser Pro Gln Leu Leu Lys Leu Leu Ile Ser Phe Ala Ser Asp 
            340                 345                 350         


Arg Asp Thr Tyr Leu Trp Ile Gly Tyr Leu Cys Ala Ile Leu Leu Phe 
        355                 360                 365             


Thr Ala Ala Leu Ile Gln Ser Phe Cys Leu Gln Cys Tyr Phe Gln Leu 
    370                 375                 380                 


Cys Phe Lys Leu Gly Val Lys Val Arg Thr Ala Ile Met Ala Ser Val 
385                 390                 395                 400 


Tyr Lys Lys Ala Leu Thr Leu Ser Asn Leu Ala Arg Lys Glu Tyr Thr 
                405                 410                 415     


Val Gly Glu Thr Val Asn Leu Met Ser Val Asp Ala Gln Lys Leu Met 
            420                 425                 430         


Asp Val Thr Asn Phe Met His Met Leu Trp Ser Ser Val Leu Gln Ile 
        435                 440                 445             


Val Leu Ser Ile Phe Phe Leu Trp Arg Glu Leu Gly Pro Ser Val Leu 
    450                 455                 460                 


Ala Gly Val Gly Val Met Val Leu Val Ile Pro Ile Asn Ala Ile Leu 
465                 470                 475                 480 


Ser Thr Lys Ser Lys Thr Ile Gln Val Lys Asn Met Lys Asn Lys Asp 
                485                 490                 495     


Lys Arg Leu Lys Ile Met Asn Glu Ile Leu Ser Gly Ile Lys Ile Leu 
            500                 505                 510         


Lys Tyr Phe Ala Trp Glu Pro Ser Phe Arg Asp Gln Val Gln Asn Leu 
        515                 520                 525             


Arg Lys Lys Glu Leu Lys Asn Leu Leu Ala Phe Ser Gln Leu Gln Cys 
    530                 535                 540                 


Val Val Ile Phe Val Phe Gln Leu Thr Pro Val Leu Val Ser Val Val 
545                 550                 555                 560 


Thr Phe Ser Val Tyr Val Leu Val Asp Ser Asn Asn Ile Leu Asp Ala 
                565                 570                 575     


Gln Lys Ala Phe Thr Ser Ile Thr Leu Phe Asn Ile Leu Arg Phe Pro 
            580                 585                 590         


Leu Ser Met Leu Pro Met Met Ile Ser Ser Met Leu Gln Ala Ser Val 
        595                 600                 605             


Ser Thr Glu Arg Leu Glu Lys Tyr Leu Gly Gly Asp Asp Leu Asp Thr 
    610                 615                 620                 


Ser Ala Ile Arg His Asp Cys Asn Phe Asp Lys Ala Met Gln Phe Ser 
625                 630                 635                 640 


Glu Ala Ser Phe Thr Trp Glu His Asp Ser Glu Ala Thr Val Arg Asp 
                645                 650                 655     


Val Asn Leu Asp Ile Met Ala Gly Gln Leu Val Ala Val Ile Gly Pro 
            660                 665                 670         


Val Gly Ser Gly Lys Ser Ser Leu Ile Ser Ala Met Leu Gly Glu Met 
        675                 680                 685             


Glu Asn Val His Gly His Ile Thr Ile Lys Gly Thr Thr Ala Tyr Val 
    690                 695                 700                 


Pro Gln Gln Ser Trp Ile Gln Asn Gly Thr Ile Lys Asp Asn Ile Leu 
705                 710                 715                 720 


Phe Gly Thr Glu Phe Asn Glu Lys Arg Tyr Gln Gln Val Leu Glu Ala 
                725                 730                 735     


Cys Ala Leu Leu Pro Asp Leu Glu Met Leu Pro Gly Gly Asp Leu Ala 
            740                 745                 750         


Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser Gly Gly Gln Lys Gln Arg 
        755                 760                 765             


Ile Ser Leu Ala Arg Ala Thr Tyr Gln Asn Leu Asp Ile Tyr Leu Leu 
    770                 775                 780                 


Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile Phe 
785                 790                 795                 800 


Asn Lys Val Leu Gly Pro Asn Gly Leu Leu Lys Gly Lys Thr Arg Leu 
                805                 810                 815     


Leu Val Thr His Ser Met His Phe Leu Pro Gln Val Asp Glu Ile Val 
            820                 825                 830         


Val Leu Gly Asn Gly Thr Ile Val Glu Lys Gly Ser Tyr Ser Ala Leu 
        835                 840                 845             


Leu Ala Lys Lys Gly Glu Phe Ala Lys Asn Leu Lys Thr Phe Leu Arg 
    850                 855                 860                 


His Thr Gly Pro Glu Glu Glu Ala Thr Val His Asp Gly Ser Glu Glu 
865                 870                 875                 880 


Glu Asp Asp Asp Tyr Gly Leu Ile Ser Ser Val Glu Glu Ile Pro Glu 
                885                 890                 895     


Asp Ala Ala Ser Ile Thr Met Arg Arg Glu Asn Ser Phe Arg Arg Thr 
            900                 905                 910         


Leu Ser Arg Ser Ser Arg Ser Asn Gly Arg His Leu Lys Ser Leu Arg 
        915                 920                 925             


Asn Ser Leu Lys Thr Arg Asn Val Asn Ser Leu Lys Glu Asp Glu Glu 
    930                 935                 940                 


Leu Val Lys Gly Gln Lys Leu Ile Lys Lys Glu Phe Ile Glu Thr Gly 
945                 950                 955                 960 


Lys Val Lys Phe Ser Ile Tyr Leu Glu Tyr Leu Gln Ala Ile Gly Leu 
                965                 970                 975     


Phe Ser Ile Phe Phe Ile Ile Leu Ala Phe Val Met Asn Ser Val Ala 
            980                 985                 990         


Phe Ile Gly Ser Asn Leu Trp Leu  Ser Ala Trp Thr Ser  Asp Ser Lys 
        995                 1000                 1005             


Ile Phe  Asn Ser Thr Asp Tyr  Pro Ala Ser Gln Arg  Asp Met Arg 
    1010                 1015                 1020             


Val Gly  Val Tyr Gly Ala Leu  Gly Leu Ala Gln Gly  Ile Phe Val 
    1025                 1030                 1035             


Phe Ile  Ala His Phe Trp Ser  Ala Phe Gly Phe Val  His Ala Ser 
    1040                 1045                 1050             


Asn Ile  Leu His Lys Gln Leu  Leu Asn Asn Ile Leu  Arg Ala Pro 
    1055                 1060                 1065             


Met Arg  Phe Phe Asp Thr Thr  Pro Thr Gly Arg Ile  Val Asn Arg 
    1070                 1075                 1080             


Phe Ala  Gly Asp Ile Ser Thr  Val Asp Asp Thr Leu  Pro Gln Ser 
    1085                 1090                 1095             


Leu Arg  Ser Trp Ile Thr Cys  Phe Leu Gly Ile Ile  Ser Thr Leu 
    1100                 1105                 1110             


Val Met  Ile Cys Met Ala Thr  Pro Val Phe Thr Ile  Ile Val Ile 
    1115                 1120                 1125             


Pro Leu  Gly Ile Ile Tyr Val  Ser Val Gln Met Phe  Tyr Val Ser 
    1130                 1135                 1140             


Thr Ser  Arg Gln Leu Arg Arg  Leu Asp Ser Val Thr  Arg Ser Pro 
    1145                 1150                 1155             


Ile Tyr  Ser His Phe Ser Glu  Thr Val Ser Gly Leu  Pro Val Ile 
    1160                 1165                 1170             


Arg Ala  Phe Glu His Gln Gln  Arg Phe Leu Lys His  Asn Glu Val 
    1175                 1180                 1185             


Arg Ile  Asp Thr Asn Gln Lys  Cys Val Phe Ser Trp  Ile Thr Ser 
    1190                 1195                 1200             


Asn Arg  Trp Leu Ala Ile Arg  Leu Glu Leu Val Gly  Asn Leu Thr 
    1205                 1210                 1215             


Val Phe  Phe Ser Ala Leu Met  Met Val Ile Tyr Arg  Asp Thr Leu 
    1220                 1225                 1230             


Ser Gly  Asp Thr Val Gly Phe  Val Leu Ser Asn Ala  Leu Asn Ile 
    1235                 1240                 1245             


Thr Gln  Thr Leu Asn Trp Leu  Val Arg Met Thr Ser  Glu Ile Glu 
    1250                 1255                 1260             


Thr Asn  Ile Val Ala Val Glu  Arg Ile Thr Glu Tyr  Thr Lys Val 
    1265                 1270                 1275             


Glu Asn  Glu Ala Pro Trp Val  Thr Asp Lys Arg Pro  Pro Pro Asp 
    1280                 1285                 1290             


Trp Pro  Ser Lys Gly Lys Ile  Gln Phe Asn Asn Tyr  Gln Val Arg 
    1295                 1300                 1305             


Tyr Arg  Pro Glu Leu Asp Leu  Val Leu Arg Gly Ile  Thr Cys Asp 
    1310                 1315                 1320             


Ile Gly  Ser Met Glu Lys Ile  Gly Val Val Gly Arg  Thr Gly Ala 
    1325                 1330                 1335             


Gly Lys  Ser Ser Leu Thr Asn  Cys Leu Phe Arg Ile  Leu Glu Ala 
    1340                 1345                 1350             


Ala Gly  Gly Gln Ile Ile Ile  Asp Gly Val Asp Ile  Ala Ser Ile 
    1355                 1360                 1365             


Gly Leu  His Asp Leu Arg Glu  Lys Leu Thr Ile Ile  Pro Gln Asp 
    1370                 1375                 1380             


Pro Ile  Leu Phe Ser Gly Ser  Leu Arg Met Asn Leu  Asp Pro Phe 
    1385                 1390                 1395             


Asn Asn  Tyr Ser Asp Glu Glu  Ile Trp Lys Ala Leu  Glu Leu Ala 
    1400                 1405                 1410             


His Leu  Lys Ser Phe Val Ala  Ser Leu Gln Leu Gly  Leu Ser His 
    1415                 1420                 1425             


Glu Val  Thr Glu Ala Gly Gly  Asn Leu Ser Ile Gly  Gln Arg Gln 
    1430                 1435                 1440             


Leu Leu  Cys Leu Gly Arg Ala  Leu Leu Arg Lys Ser  Lys Ile Leu 
    1445                 1450                 1455             


Val Leu  Asp Glu Ala Thr Ala  Ala Val Asp Leu Glu  Thr Asp Asn 
    1460                 1465                 1470             


Leu Ile  Gln Thr Thr Ile Gln  Asn Glu Phe Ala His  Cys Thr Val 
    1475                 1480                 1485             


Ile Thr  Ile Ala His Arg Leu  His Thr Ile Met Asp  Ser Asp Lys 
    1490                 1495                 1500             


Val Met  Val Leu Asp Asn Gly  Lys Ile Ile Glu Cys  Gly Ser Pro 
    1505                 1510                 1515             


Glu Glu  Leu Leu Gln Ile Pro  Gly Pro Phe Tyr Phe  Met Ala Lys 
    1520                 1525                 1530             


Glu Ala  Gly Ile Glu Asn Val  Asn Ser Thr Lys Phe  
    1535                 1540                 1545 


<210>  55
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC3__Homo_sapiens__NP_001137542

<400>  55

Met Asp Ala Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp 
1               5                   10                  15      


Ser Asn Leu Ser Val His Thr Glu Asn Pro Asp Leu Thr Pro Cys Phe 
            20                  25                  30          


Gln Asn Ser Leu Leu Ala Trp Val Pro Cys Ile Tyr Leu Trp Val Ala 
        35                  40                  45              


Leu Pro Cys Tyr Leu Leu Tyr Leu Arg His His Cys Arg Gly Tyr Ile 
    50                  55                  60                  


Ile Leu Ser His Leu Ser Lys Leu Lys Met Val Leu Gly Val Leu Leu 
65                  70                  75                  80  


Trp Cys Val Ser Trp Ala Asp Leu Phe Tyr Ser Phe His Gly Leu Val 
                85                  90                  95      


His Gly Arg Ala Pro Ala Pro Val Phe Phe Val Thr Pro Leu Val Val 
            100                 105                 110         


Gly Val Thr Met Leu Leu Ala Thr Leu Leu Ile Gln Tyr Glu Arg Leu 
        115                 120                 125             


Gln Gly Val Gln Ser Ser Gly Val Leu Ile Ile Phe Trp Phe Leu Cys 
    130                 135                 140                 


Val Val Cys Ala Ile Val Pro Phe Arg Ser Lys Ile Leu Leu Ala Lys 
145                 150                 155                 160 


Ala Glu Gly Glu Ile Ser Asp Pro Phe Arg Phe Thr Thr Phe Tyr Ile 
                165                 170                 175     


His Phe Ala Leu Val Leu Ser Ala Leu Ile Leu Ala Cys Phe Arg Glu 
            180                 185                 190         


Lys Pro Pro Phe Phe Ser Ala Lys Asn Val Asp Pro Asn Pro Tyr Pro 
        195                 200                 205             


Glu Thr Ser Ala Gly Phe Leu Ser Arg Leu Phe Phe Trp Trp Phe Thr 
    210                 215                 220                 


Lys Met Ala Ile Tyr Gly Tyr Arg His Pro Leu Glu Glu Lys Asp Leu 
225                 230                 235                 240 


Trp Ser Leu Lys Glu Glu Asp Arg Ser Gln Met Val Val Gln Gln Leu 
                245                 250                 255     


Leu Glu Ala Trp Arg Lys Gln Glu Lys Gln Thr Ala Arg His Lys Ala 
            260                 265                 270         


Ser Ala Ala Pro Gly Lys Asn Ala Ser Gly Glu Asp Glu Val Leu Leu 
        275                 280                 285             


Gly Ala Arg Pro Arg Pro Arg Lys Pro Ser Phe Leu Lys Ala Leu Leu 
    290                 295                 300                 


Ala Thr Phe Gly Ser Ser Phe Leu Ile Ser Ala Cys Phe Lys Leu Ile 
305                 310                 315                 320 


Gln Asp Leu Leu Ser Phe Ile Asn Pro Gln Leu Leu Ser Ile Leu Ile 
                325                 330                 335     


Arg Phe Ile Ser Asn Pro Met Ala Pro Ser Trp Trp Gly Phe Leu Val 
            340                 345                 350         


Ala Gly Leu Met Phe Leu Cys Ser Met Met Gln Ser Leu Ile Leu Gln 
        355                 360                 365             


His Tyr Tyr His Tyr Ile Phe Val Thr Gly Val Lys Phe Arg Thr Gly 
    370                 375                 380                 


Ile Met Gly Val Ile Tyr Arg Lys Ala Leu Val Ile Thr Asn Ser Val 
385                 390                 395                 400 


Lys Arg Ala Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser Val Asp 
                405                 410                 415     


Ala Gln Arg Phe Met Asp Leu Ala Pro Phe Leu Asn Leu Leu Trp Ser 
            420                 425                 430         


Ala Pro Leu Gln Ile Ile Leu Ala Ile Tyr Phe Leu Trp Gln Asn Leu 
        435                 440                 445             


Gly Pro Ser Val Leu Ala Gly Val Ala Phe Met Val Leu Leu Ile Pro 
    450                 455                 460                 


Leu Asn Gly Ala Val Ala Val Lys Met Arg Ala Phe Gln Val Lys Gln 
465                 470                 475                 480 


Met Lys Leu Lys Asp Ser Arg Ile Lys Leu Met Ser Glu Ile Leu Asn 
                485                 490                 495     


Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Pro Ser Phe Leu Lys 
            500                 505                 510         


Gln Val Glu Gly Ile Arg Gln Gly Glu Leu Gln Leu Leu Arg Thr Ala 
        515                 520                 525             


Ala Tyr Leu His Thr Thr Thr Thr Phe Thr Trp Met Cys Ser Pro Phe 
    530                 535                 540                 


Leu Val Arg Leu Gly Thr Gly Leu Gly Pro Cys Leu Gln Gly Ser Gly 
545                 550                 555                 560 


Cys Pro Gly Met Ala Arg Ala His Trp Thr Leu Pro 
                565                 570         


<210>  56
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC4__Homo_sapiens__NP_001098985

<400>  56

Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala 
1               5                   10                  15      


Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys 
            20                  25                  30          


Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp 
    50                  55                  60                  


Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu 
65                  70                  75                  80  


Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly 
                85                  90                  95      


Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe 
            100                 105                 110         


Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser 
        115                 120                 125             


Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys 
    130                 135                 140                 


Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln 
145                 150                 155                 160 


Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg 
                165                 170                 175     


Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly 
            180                 185                 190         


Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val 
        195                 200                 205             


Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala 
    210                 215                 220                 


Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly 
225                 230                 235                 240 


Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys 
                245                 250                 255     


Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg 
            260                 265                 270         


Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met 
        275                 280                 285             


Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys 
    290                 295                 300                 


Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn 
305                 310                 315                 320 


Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe 
                325                 330                 335     


Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe 
            340                 345                 350         


Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe 
        355                 360                 365             


Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg 
    370                 375                 380                 


Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg 
385                 390                 395                 400 


Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr 
                405                 410                 415     


Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser 
            420                 425                 430         


Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly 
        435                 440                 445             


Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro 
    450                 455                 460                 


Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln 
465                 470                 475                 480 


Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly 
                485                 490                 495     


Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala 
            500                 505                 510         


Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile 
        515                 520                 525             


Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn 
    530                 535                 540                 


Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp 
545                 550                 555                 560 


Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu 
                565                 570                 575     


Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His 
            580                 585                 590         


Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp 
        595                 600                 605             


Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly 
    610                 615                 620                 


Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln 
625                 630                 635                 640 


Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu 
                645                 650                 655     


Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly 
            660                 665                 670         


Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu 
        675                 680                 685             


Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr 
    690                 695                 700                 


Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu 
705                 710                 715                 720 


Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser 
                725                 730                 735     


Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly 
            740                 745                 750         


Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr 
        755                 760                 765             


Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu 
    770                 775                 780                 


Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys 
785                 790                 795                 800 


Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn 
                805                 810                 815     


Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu 
            820                 825                 830         


Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Arg Trp Asp 
        835                 840                 845             


Leu Ala Val Leu Ser Trp Leu Val Ser Asn Ser 
    850                 855                 


<210>  57
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC5__Homo_sapiens__NP_001018881

<400>  57

Met Lys Asp Ile Asp Ile Gly Lys Glu Tyr Ile Ile Pro Ser Pro Gly 
1               5                   10                  15      


Tyr Arg Ser Val Arg Glu Arg Thr Ser Thr Ser Gly Thr His Arg Asp 
            20                  25                  30          


Arg Glu Asp Ser Lys Phe Arg Arg Thr Arg Pro Leu Glu Cys Gln Asp 
        35                  40                  45              


Ala Leu Glu Thr Ala Ala Arg Ala Glu Gly Leu Ser Leu Asp Ala Ser 
    50                  55                  60                  


Met His Ser Gln Leu Arg Ile Leu Asp Glu Glu His Pro Lys Gly Lys 
65                  70                  75                  80  


Tyr His His Gly Leu Ser Ala Leu Lys Pro Ile Arg Thr Thr Ser Lys 
                85                  90                  95      


His Gln His Pro Val Asp Asn Ala Gly Leu Phe Ser Cys Met Thr Phe 
            100                 105                 110         


Ser Trp Leu Ser Ser Leu Ala Arg Val Ala His Lys Lys Gly Glu Leu 
        115                 120                 125             


Ser Met Glu Asp Val Trp Ser Leu Ser Lys His Glu Ser Ser Asp Val 
    130                 135                 140                 


Asn Cys Arg Arg Leu Glu Arg Leu Trp Gln Glu Glu Leu Asn Glu Val 
145                 150                 155                 160 


Gly Pro Asp Ala Ala Ser Leu Arg Arg Val Val Trp Ile Phe Cys Arg 
                165                 170                 175     


Thr Arg Leu Ile Leu Ser Ile Val Cys Leu Met Ile Thr Gln Leu Ala 
            180                 185                 190         


Gly Phe Ser Gly Pro Asn Phe Gln Asp Gly Cys Ile Leu Arg Ser Glu 
        195                 200                 205             


<210>  58
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC6__Homo_sapiens__NP_001072996

<400>  58

Met Ala Ala Pro Ala Glu Pro Cys Ala Gly Gln Gly Val Trp Asn Gln 
1               5                   10                  15      


Thr Glu Pro Glu Pro Ala Ala Thr Ser Leu Leu Ser Leu Cys Phe Leu 
            20                  25                  30          


Arg Thr Ala Gly Val Trp Val Pro Pro Met Tyr Leu Trp Val Leu Gly 
        35                  40                  45              


Pro Ile Tyr Leu Leu Phe Ile His His His Gly Arg Gly Tyr Leu Arg 
    50                  55                  60                  


Met Ser Pro Leu Phe Lys Ala Lys Met Val Ala Ala Ile Pro Gly Ser 
65                  70                  75                  80  


Leu Glu Pro Gly Asn Val Arg Gly Arg Gln Gly Thr Gly Trp Asn Leu 
                85                  90                  95      


Val Lys Ser 
            


<210>  59
<211>  1581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC8__Homo_sapiens__NP_000343

<400>  59

Met Pro Leu Ala Phe Cys Gly Ser Glu Asn His Ser Ala Ala Tyr Arg 
1               5                   10                  15      


Val Asp Gln Gly Val Leu Asn Asn Gly Cys Phe Val Asp Ala Leu Asn 
            20                  25                  30          


Val Val Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe 
        35                  40                  45              


Ile Gly Trp Gly Ser Gln Ser Ser Lys Val His Ile His His Ser Thr 
    50                  55                  60                  


Trp Leu His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Met 
65                  70                  75                  80  


Leu Leu Phe Val Leu Val Cys Glu Ile Ala Glu Gly Ile Leu Ser Asp 
                85                  90                  95      


Gly Val Thr Glu Ser His His Leu His Leu Tyr Met Pro Ala Gly Met 
            100                 105                 110         


Ala Phe Met Ala Ala Val Thr Ser Val Val Tyr Tyr His Asn Ile Glu 
        115                 120                 125             


Thr Ser Asn Phe Pro Lys Leu Leu Ile Ala Leu Leu Val Tyr Trp Thr 
    130                 135                 140                 


Leu Ala Phe Ile Thr Lys Thr Ile Lys Phe Val Lys Phe Leu Asp His 
145                 150                 155                 160 


Ala Ile Gly Phe Ser Gln Leu Arg Phe Cys Leu Thr Gly Leu Leu Val 
                165                 170                 175     


Ile Leu Tyr Gly Met Leu Leu Leu Val Glu Val Asn Val Ile Arg Val 
            180                 185                 190         


Arg Arg Tyr Ile Phe Phe Lys Thr Pro Arg Glu Val Lys Pro Pro Glu 
        195                 200                 205             


Asp Leu Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu 
    210                 215                 220                 


Leu Ser Lys Gly Thr Tyr Trp Trp Met Asn Ala Phe Ile Lys Thr Ala 
225                 230                 235                 240 


His Lys Lys Pro Ile Asp Leu Arg Ala Ile Gly Lys Leu Pro Ile Ala 
                245                 250                 255     


Met Arg Ala Leu Thr Asn Tyr Gln Arg Leu Cys Glu Ala Phe Asp Ala 
            260                 265                 270         


Gln Val Arg Lys Asp Ile Gln Gly Thr Gln Gly Ala Arg Ala Ile Trp 
        275                 280                 285             


Gln Ala Leu Ser His Ala Phe Gly Arg Arg Leu Val Leu Ser Ser Thr 
    290                 295                 300                 


Phe Arg Ile Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile 
305                 310                 315                 320 


Phe Gly Ile Val Asp His Leu Gly Lys Glu Asn Asp Val Phe Gln Pro 
                325                 330                 335     


Lys Thr Gln Phe Leu Gly Val Tyr Phe Val Ser Ser Gln Glu Phe Leu 
            340                 345                 350         


Ala Asn Ala Tyr Val Leu Ala Val Leu Leu Phe Leu Ala Leu Leu Leu 
        355                 360                 365             


Gln Arg Thr Phe Leu Gln Ala Ser Tyr Tyr Val Ala Ile Glu Thr Gly 
    370                 375                 380                 


Ile Asn Leu Arg Gly Ala Ile Gln Thr Lys Ile Tyr Asn Lys Ile Met 
385                 390                 395                 400 


His Leu Ser Thr Ser Asn Leu Ser Met Gly Glu Met Thr Ala Gly Gln 
                405                 410                 415     


Ile Cys Asn Leu Val Ala Ile Asp Thr Asn Gln Leu Met Trp Phe Phe 
            420                 425                 430         


Phe Leu Cys Pro Asn Leu Trp Ala Met Pro Val Gln Ile Ile Val Gly 
        435                 440                 445             


Val Ile Leu Leu Tyr Tyr Ile Leu Gly Val Ser Ala Leu Ile Gly Ala 
    450                 455                 460                 


Ala Val Ile Ile Leu Leu Ala Pro Val Gln Tyr Phe Val Ala Thr Lys 
465                 470                 475                 480 


Leu Ser Gln Ala Gln Arg Ser Thr Leu Glu Tyr Ser Asn Glu Arg Leu 
                485                 490                 495     


Lys Gln Thr Asn Glu Met Leu Arg Gly Ile Lys Leu Leu Lys Leu Tyr 
            500                 505                 510         


Ala Trp Glu Asn Ile Phe Arg Thr Arg Val Glu Thr Thr Arg Arg Lys 
        515                 520                 525             


Glu Met Thr Ser Leu Arg Ala Phe Ala Ile Tyr Thr Ser Ile Ser Ile 
    530                 535                 540                 


Phe Met Asn Thr Ala Ile Pro Ile Ala Ala Val Leu Ile Thr Phe Val 
545                 550                 555                 560 


Gly His Val Ser Phe Phe Lys Glu Ala Asp Phe Ser Pro Ser Val Ala 
                565                 570                 575     


Phe Ala Ser Leu Ser Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu 
            580                 585                 590         


Leu Ser Ser Val Val Arg Ser Thr Val Lys Ala Leu Val Ser Val Gln 
        595                 600                 605             


Lys Leu Ser Glu Phe Leu Ser Ser Ala Glu Ile Arg Glu Glu Gln Cys 
    610                 615                 620                 


Ala Pro His Glu Pro Thr Pro Gln Gly Pro Ala Ser Lys Tyr Gln Ala 
625                 630                 635                 640 


Val Pro Leu Arg Val Val Asn Arg Lys Arg Pro Ala Arg Glu Asp Cys 
                645                 650                 655     


Arg Gly Leu Thr Gly Pro Leu Gln Ser Leu Val Pro Ser Ala Asp Gly 
            660                 665                 670         


Asp Ala Asp Asn Cys Cys Val Gln Ile Met Gly Gly Tyr Phe Thr Trp 
        675                 680                 685             


Thr Pro Asp Gly Ile Pro Thr Leu Ser Asn Ile Thr Ile Arg Ile Pro 
    690                 695                 700                 


Arg Gly Gln Leu Thr Met Ile Val Gly Gln Val Gly Cys Gly Lys Ser 
705                 710                 715                 720 


Ser Leu Leu Leu Ala Ala Leu Gly Glu Met Gln Lys Val Ser Gly Ala 
                725                 730                 735     


Val Phe Trp Ser Ser Leu Pro Asp Ser Glu Ile Gly Glu Asp Pro Ser 
            740                 745                 750         


Pro Glu Arg Glu Thr Ala Thr Asp Leu Asp Ile Arg Lys Arg Gly Pro 
        755                 760                 765             


Val Ala Tyr Ala Ser Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu 
    770                 775                 780                 


Glu Asn Ile Ile Phe Glu Ser Pro Phe Asn Lys Gln Arg Tyr Lys Met 
785                 790                 795                 800 


Val Ile Glu Ala Cys Ser Leu Gln Pro Asp Ile Asp Ile Leu Pro His 
                805                 810                 815     


Gly Asp Gln Thr Gln Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly 
            820                 825                 830         


Gln Arg Gln Arg Ile Ser Val Ala Arg Ala Leu Tyr Gln His Ala Asn 
        835                 840                 845             


Val Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser 
    850                 855                 860                 


Asp His Leu Met Gln Ala Gly Ile Leu Glu Leu Leu Arg Asp Asp Lys 
865                 870                 875                 880 


Arg Thr Val Val Leu Val Thr His Lys Leu Gln Tyr Leu Pro His Ala 
                885                 890                 895     


Asp Trp Ile Ile Ala Met Lys Asp Gly Thr Ile Gln Arg Glu Gly Thr 
            900                 905                 910         


Leu Lys Asp Phe Gln Arg Ser Glu Cys Gln Leu Phe Glu His Trp Lys 
        915                 920                 925             


Thr Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Glu Thr Val Thr 
    930                 935                 940                 


Glu Arg Lys Ala Thr Glu Pro Pro Gln Gly Leu Ser Arg Ala Met Ser 
945                 950                 955                 960 


Ser Arg Asp Gly Leu Leu Gln Asp Glu Glu Glu Glu Glu Glu Glu Ala 
                965                 970                 975     


Ala Glu Ser Glu Glu Asp Asp Asn Leu Ser Ser Met Leu His Gln Arg 
            980                 985                 990         


Ala Glu Ile Pro Trp Arg Ala Cys  Ala Lys Tyr Leu Ser  Ser Ala Gly 
        995                 1000                 1005             


Ile Leu  Leu Leu Ser Leu Leu  Val Phe Ser Gln Leu  Leu Lys His 
    1010                 1015                 1020             


Met Val  Leu Val Ala Ile Asp  Tyr Trp Leu Ala Lys  Trp Thr Asp 
    1025                 1030                 1035             


Ser Ala  Leu Thr Leu Thr Pro  Ala Ala Arg Asn Cys  Ser Leu Ser 
    1040                 1045                 1050             


Gln Glu  Cys Thr Leu Asp Gln  Thr Val Tyr Ala Met  Val Phe Thr 
    1055                 1060                 1065             


Val Leu  Cys Ser Leu Gly Ile  Val Leu Cys Leu Val  Thr Ser Val 
    1070                 1075                 1080             


Thr Val  Glu Trp Thr Gly Leu  Lys Val Ala Lys Arg  Leu His Arg 
    1085                 1090                 1095             


Ser Leu  Leu Asn Arg Ile Ile  Leu Ala Pro Met Arg  Phe Phe Glu 
    1100                 1105                 1110             


Thr Thr  Pro Leu Gly Ser Ile  Leu Asn Arg Phe Ser  Ser Asp Cys 
    1115                 1120                 1125             


Asn Thr  Ile Asp Gln His Ile  Pro Ser Thr Leu Glu  Cys Leu Ser 
    1130                 1135                 1140             


Arg Ser  Thr Leu Leu Cys Val  Ser Ala Leu Ala Val  Ile Ser Tyr 
    1145                 1150                 1155             


Val Thr  Pro Val Phe Leu Val  Ala Leu Leu Pro Leu  Ala Ile Val 
    1160                 1165                 1170             


Cys Tyr  Phe Ile Gln Lys Tyr  Phe Arg Val Ala Ser  Arg Asp Leu 
    1175                 1180                 1185             


Gln Gln  Leu Asp Asp Thr Thr  Gln Leu Pro Leu Leu  Ser His Phe 
    1190                 1195                 1200             


Ala Glu  Thr Val Glu Gly Leu  Thr Thr Ile Arg Ala  Phe Arg Tyr 
    1205                 1210                 1215             


Glu Ala  Arg Phe Gln Gln Lys  Leu Leu Glu Tyr Thr  Asp Ser Asn 
    1220                 1225                 1230             


Asn Ile  Ala Ser Leu Phe Leu  Thr Ala Ala Asn Arg  Trp Leu Glu 
    1235                 1240                 1245             


Val Arg  Met Glu Tyr Ile Gly  Ala Cys Val Val Leu  Ile Ala Ala 
    1250                 1255                 1260             


Val Thr  Ser Ile Ser Asn Ser  Leu His Arg Glu Leu  Ser Ala Gly 
    1265                 1270                 1275             


Leu Val  Gly Leu Gly Leu Thr  Tyr Ala Leu Met Val  Ser Asn Tyr 
    1280                 1285                 1290             


Leu Asn  Trp Met Val Arg Asn  Leu Ala Asp Met Glu  Leu Gln Leu 
    1295                 1300                 1305             


Gly Ala  Val Lys Arg Ile His  Gly Leu Leu Lys Thr  Glu Ala Glu 
    1310                 1315                 1320             


Ser Tyr  Glu Gly Leu Leu Ala  Pro Ser Leu Ile Pro  Lys Asn Trp 
    1325                 1330                 1335             


Pro Asp  Gln Gly Lys Ile Gln  Ile Gln Asn Leu Ser  Val Arg Tyr 
    1340                 1345                 1350             


Asp Ser  Ser Leu Lys Pro Val  Leu Lys His Val Asn  Ala Leu Ile 
    1355                 1360                 1365             


Ala Pro  Gly Gln Lys Ile Gly  Ile Cys Gly Arg Thr  Gly Ser Gly 
    1370                 1375                 1380             


Lys Ser  Ser Phe Ser Leu Ala  Phe Phe Arg Met Val  Asp Thr Phe 
    1385                 1390                 1395             


Glu Gly  His Ile Ile Ile Asp  Gly Ile Asp Ile Ala  Lys Leu Pro 
    1400                 1405                 1410             


Leu His  Thr Leu Arg Ser Arg  Leu Ser Ile Ile Leu  Gln Asp Pro 
    1415                 1420                 1425             


Val Leu  Phe Ser Gly Thr Ile  Arg Phe Asn Leu Asp  Pro Glu Arg 
    1430                 1435                 1440             


Lys Cys  Ser Asp Ser Thr Leu  Trp Glu Ala Leu Glu  Ile Ala Gln 
    1445                 1450                 1455             


Leu Lys  Leu Val Val Lys Ala  Leu Pro Gly Gly Leu  Asp Ala Ile 
    1460                 1465                 1470             


Ile Thr  Glu Gly Gly Glu Asn  Phe Ser Gln Gly Gln  Arg Gln Leu 
    1475                 1480                 1485             


Phe Cys  Leu Ala Arg Ala Phe  Val Arg Lys Thr Ser  Ile Phe Ile 
    1490                 1495                 1500             


Met Asp  Glu Ala Thr Ala Ser  Ile Asp Met Ala Thr  Glu Asn Ile 
    1505                 1510                 1515             


Leu Gln  Lys Val Val Met Thr  Ala Phe Ala Asp Arg  Thr Val Val 
    1520                 1525                 1530             


Thr Ile  Ala His Arg Val His  Thr Ile Leu Ser Ala  Asp Leu Val 
    1535                 1540                 1545             


Ile Val  Leu Lys Arg Gly Ala  Ile Leu Glu Phe Asp  Lys Pro Glu 
    1550                 1555                 1560             


Lys Leu  Leu Ser Arg Lys Asp  Ser Val Phe Ala Ser  Phe Val Arg 
    1565                 1570                 1575             


Ala Asp  Lys 
    1580     


<210>  60
<211>  1549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCC9__Homo_sapiens__NP_005682

<400>  60

Met Ser Leu Ser Phe Cys Gly Asn Asn Ile Ser Ser Tyr Asn Ile Asn 
1               5                   10                  15      


Asp Gly Val Leu Gln Asn Ser Cys Phe Val Asp Ala Leu Asn Leu Val 
            20                  25                  30          


Pro His Val Phe Leu Leu Phe Ile Thr Phe Pro Ile Leu Phe Ile Gly 
        35                  40                  45              


Trp Gly Ser Gln Ser Ser Lys Val Gln Ile His His Asn Thr Trp Leu 
    50                  55                  60                  


His Phe Pro Gly His Asn Leu Arg Trp Ile Leu Thr Phe Ala Leu Leu 
65                  70                  75                  80  


Phe Val His Val Cys Glu Ile Ala Glu Gly Ile Val Ser Asp Ser Arg 
                85                  90                  95      


Arg Glu Ser Arg His Leu His Leu Phe Met Pro Ala Val Met Gly Phe 
            100                 105                 110         


Val Ala Thr Thr Thr Ser Ile Val Tyr Tyr His Asn Ile Glu Thr Ser 
        115                 120                 125             


Asn Phe Pro Lys Leu Leu Leu Ala Leu Phe Leu Tyr Trp Val Met Ala 
    130                 135                 140                 


Phe Ile Thr Lys Thr Ile Lys Leu Val Lys Tyr Cys Gln Ser Gly Leu 
145                 150                 155                 160 


Asp Ile Ser Asn Leu Arg Phe Cys Ile Thr Gly Met Met Val Ile Leu 
                165                 170                 175     


Asn Gly Leu Leu Met Ala Val Glu Ile Asn Val Ile Arg Val Arg Arg 
            180                 185                 190         


Tyr Val Phe Phe Met Asn Pro Gln Lys Val Lys Pro Pro Glu Asp Leu 
        195                 200                 205             


Gln Asp Leu Gly Val Arg Phe Leu Gln Pro Phe Val Asn Leu Leu Ser 
    210                 215                 220                 


Lys Ala Thr Tyr Trp Trp Met Asn Thr Leu Ile Ile Ser Ala His Lys 
225                 230                 235                 240 


Lys Pro Ile Asp Leu Lys Ala Ile Gly Lys Leu Pro Ile Ala Met Arg 
                245                 250                 255     


Ala Val Thr Asn Tyr Val Cys Leu Lys Asp Ala Tyr Glu Glu Gln Lys 
            260                 265                 270         


Lys Lys Val Ala Asp His Pro Asn Arg Thr Pro Ser Ile Trp Leu Ala 
        275                 280                 285             


Met Tyr Arg Ala Phe Gly Arg Pro Ile Leu Leu Ser Ser Thr Phe Arg 
    290                 295                 300                 


Tyr Leu Ala Asp Leu Leu Gly Phe Ala Gly Pro Leu Cys Ile Ser Gly 
305                 310                 315                 320 


Ile Val Gln Arg Val Asn Glu Thr Gln Asn Gly Thr Asn Asn Thr Thr 
                325                 330                 335     


Gly Ile Ser Glu Thr Leu Ser Ser Lys Glu Phe Leu Glu Asn Ala Tyr 
            340                 345                 350         


Val Leu Ala Val Leu Leu Phe Leu Ala Leu Ile Leu Gln Arg Thr Phe 
        355                 360                 365             


Leu Gln Ala Ser Tyr Tyr Val Thr Ile Glu Thr Gly Ile Asn Leu Arg 
    370                 375                 380                 


Gly Ala Leu Leu Ala Met Ile Tyr Asn Lys Ile Leu Arg Leu Ser Thr 
385                 390                 395                 400 


Ser Asn Leu Ser Met Gly Glu Met Thr Leu Gly Gln Ile Asn Asn Leu 
                405                 410                 415     


Val Ala Ile Glu Thr Asn Gln Leu Met Trp Phe Leu Phe Leu Cys Pro 
            420                 425                 430         


Asn Leu Trp Ala Met Pro Val Gln Ile Ile Met Gly Val Ile Leu Leu 
        435                 440                 445             


Tyr Asn Leu Leu Gly Ser Ser Ala Leu Val Gly Ala Ala Val Ile Val 
    450                 455                 460                 


Leu Leu Ala Pro Ile Gln Tyr Phe Ile Ala Thr Lys Leu Ala Glu Ala 
465                 470                 475                 480 


Gln Lys Ser Thr Leu Asp Tyr Ser Thr Glu Arg Leu Lys Lys Thr Asn 
                485                 490                 495     


Glu Ile Leu Lys Gly Ile Lys Leu Leu Lys Leu Tyr Ala Trp Glu His 
            500                 505                 510         


Ile Phe Cys Lys Ser Val Glu Glu Thr Arg Met Lys Glu Leu Ser Ser 
        515                 520                 525             


Leu Lys Thr Phe Ala Leu Tyr Thr Ser Leu Ser Ile Phe Met Asn Ala 
    530                 535                 540                 


Ala Ile Pro Ile Ala Ala Val Leu Ala Thr Phe Val Thr His Ala Tyr 
545                 550                 555                 560 


Ala Ser Gly Asn Asn Leu Lys Pro Ala Glu Ala Phe Ala Ser Leu Ser 
                565                 570                 575     


Leu Phe His Ile Leu Val Thr Pro Leu Phe Leu Leu Ser Thr Val Val 
            580                 585                 590         


Arg Phe Ala Val Lys Ala Ile Ile Ser Val Gln Lys Leu Asn Glu Phe 
        595                 600                 605             


Leu Leu Ser Asp Glu Ile Gly Asp Asp Ser Trp Arg Thr Gly Glu Ser 
    610                 615                 620                 


Ser Leu Pro Phe Glu Ser Cys Lys Lys His Thr Gly Val Gln Pro Lys 
625                 630                 635                 640 


Thr Ile Asn Arg Lys Gln Pro Gly Arg Tyr His Leu Asp Ser Tyr Glu 
                645                 650                 655     


Gln Ser Thr Arg Arg Leu Arg Pro Ala Glu Thr Glu Asp Ile Ala Ile 
            660                 665                 670         


Lys Val Thr Asn Gly Tyr Phe Ser Trp Gly Ser Gly Leu Ala Thr Leu 
        675                 680                 685             


Ser Asn Ile Asp Ile Arg Ile Pro Thr Gly Gln Leu Thr Met Ile Val 
    690                 695                 700                 


Gly Gln Val Gly Cys Gly Lys Ser Ser Leu Leu Leu Ala Ile Leu Gly 
705                 710                 715                 720 


Glu Met Gln Thr Leu Glu Gly Lys Val His Trp Ser Asn Val Asn Glu 
                725                 730                 735     


Ser Glu Pro Ser Phe Glu Ala Thr Arg Ser Arg Asn Arg Tyr Ser Val 
            740                 745                 750         


Ala Tyr Ala Ala Gln Lys Pro Trp Leu Leu Asn Ala Thr Val Glu Glu 
        755                 760                 765             


Asn Ile Thr Phe Gly Ser Pro Phe Asn Lys Gln Arg Tyr Lys Ala Val 
    770                 775                 780                 


Thr Asp Ala Cys Ser Leu Gln Pro Asp Ile Asp Leu Leu Pro Phe Gly 
785                 790                 795                 800 


Asp Gln Thr Glu Ile Gly Glu Arg Gly Ile Asn Leu Ser Gly Gly Gln 
                805                 810                 815     


Arg Gln Arg Ile Cys Val Ala Arg Ala Leu Tyr Gln Asn Thr Asn Ile 
            820                 825                 830         


Val Phe Leu Asp Asp Pro Phe Ser Ala Leu Asp Ile His Leu Ser Asp 
        835                 840                 845             


His Leu Met Gln Glu Gly Ile Leu Lys Phe Leu Gln Asp Asp Lys Arg 
    850                 855                 860                 


Thr Leu Val Leu Val Thr His Lys Leu Gln Tyr Leu Thr His Ala Asp 
865                 870                 875                 880 


Trp Ile Ile Ala Met Lys Asp Gly Ser Val Leu Arg Glu Gly Thr Leu 
                885                 890                 895     


Lys Asp Ile Gln Thr Lys Asp Val Glu Leu Tyr Glu His Trp Lys Thr 
            900                 905                 910         


Leu Met Asn Arg Gln Asp Gln Glu Leu Glu Lys Asp Met Glu Ala Asp 
        915                 920                 925             


Gln Thr Thr Leu Glu Arg Lys Thr Leu Arg Arg Ala Met Tyr Ser Arg 
    930                 935                 940                 


Glu Ala Lys Ala Gln Met Glu Asp Glu Asp Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Glu Asp Asp Asn Met Ser Thr Val Met Arg Leu Arg Thr Lys 
                965                 970                 975     


Met Pro Trp Lys Thr Cys Trp Arg Tyr Leu Thr Ser Gly Gly Phe Phe 
            980                 985                 990         


Leu Leu Ile Leu Met Ile Phe Ser  Lys Leu Leu Lys His  Ser Val Ile 
        995                 1000                 1005             


Val Ala  Ile Asp Tyr Trp Leu  Ala Thr Trp Thr Ser  Glu Tyr Ser 
    1010                 1015                 1020             


Ile Asn  Asn Thr Gly Lys Ala  Asp Gln Thr Tyr Tyr  Val Ala Gly 
    1025                 1030                 1035             


Phe Ser  Ile Leu Cys Gly Ala  Gly Ile Phe Leu Cys  Leu Val Thr 
    1040                 1045                 1050             


Ser Leu  Thr Val Glu Trp Met  Gly Leu Thr Ala Ala  Lys Asn Leu 
    1055                 1060                 1065             


His His  Asn Leu Leu Asn Lys  Ile Ile Leu Gly Pro  Ile Arg Phe 
    1070                 1075                 1080             


Phe Asp  Thr Thr Pro Leu Gly  Leu Ile Leu Asn Arg  Phe Ser Ala 
    1085                 1090                 1095             


Asp Thr  Asn Ile Ile Asp Gln  His Ile Pro Pro Thr  Leu Glu Ser 
    1100                 1105                 1110             


Leu Thr  Arg Ser Thr Leu Leu  Cys Leu Ser Ala Ile  Gly Met Ile 
    1115                 1120                 1125             


Ser Tyr  Ala Thr Pro Val Phe  Leu Val Ala Leu Leu  Pro Leu Gly 
    1130                 1135                 1140             


Val Ala  Phe Tyr Phe Ile Gln  Lys Tyr Phe Arg Val  Ala Ser Lys 
    1145                 1150                 1155             


Asp Leu  Gln Glu Leu Asp Asp  Ser Thr Gln Leu Pro  Leu Leu Cys 
    1160                 1165                 1170             


His Phe  Ser Glu Thr Ala Glu  Gly Leu Thr Thr Ile  Arg Ala Phe 
    1175                 1180                 1185             


Arg His  Glu Thr Arg Phe Lys  Gln Arg Met Leu Glu  Leu Thr Asp 
    1190                 1195                 1200             


Thr Asn  Asn Ile Ala Tyr Leu  Phe Leu Ser Ala Ala  Asn Arg Trp 
    1205                 1210                 1215             


Leu Glu  Val Arg Thr Asp Tyr  Leu Gly Ala Cys Ile  Val Leu Thr 
    1220                 1225                 1230             


Ala Ser  Ile Ala Ser Ile Ser  Gly Ser Ser Asn Ser  Gly Leu Val 
    1235                 1240                 1245             


Gly Leu  Gly Leu Leu Tyr Ala  Leu Thr Ile Thr Asn  Tyr Leu Asn 
    1250                 1255                 1260             


Trp Val  Val Arg Asn Leu Ala  Asp Leu Glu Val Gln  Met Gly Ala 
    1265                 1270                 1275             


Val Lys  Lys Val Asn Ser Phe  Leu Thr Met Glu Ser  Glu Asn Tyr 
    1280                 1285                 1290             


Glu Gly  Thr Met Asp Pro Ser  Gln Val Pro Glu His  Trp Pro Gln 
    1295                 1300                 1305             


Glu Gly  Glu Ile Lys Ile His  Asp Leu Cys Val Arg  Tyr Glu Asn 
    1310                 1315                 1320             


Asn Leu  Lys Pro Val Leu Lys  His Val Lys Ala Tyr  Ile Lys Pro 
    1325                 1330                 1335             


Gly Gln  Lys Val Gly Ile Cys  Gly Arg Thr Gly Ser  Gly Lys Ser 
    1340                 1345                 1350             


Ser Leu  Ser Leu Ala Phe Phe  Arg Met Val Asp Ile  Phe Asp Gly 
    1355                 1360                 1365             


Lys Ile  Val Ile Asp Gly Ile  Asp Ile Ser Lys Leu  Pro Leu His 
    1370                 1375                 1380             


Thr Leu  Arg Ser Arg Leu Ser  Ile Ile Leu Gln Asp  Pro Ile Leu 
    1385                 1390                 1395             


Phe Ser  Gly Ser Ile Arg Phe  Asn Leu Asp Pro Glu  Cys Lys Cys 
    1400                 1405                 1410             


Thr Asp  Asp Arg Leu Trp Glu  Ala Leu Glu Ile Ala  Gln Leu Lys 
    1415                 1420                 1425             


Asn Met  Val Lys Ser Leu Pro  Gly Gly Leu Asp Ala  Val Val Thr 
    1430                 1435                 1440             


Glu Gly  Gly Glu Asn Phe Ser  Val Gly Gln Arg Gln  Leu Phe Cys 
    1445                 1450                 1455             


Leu Ala  Arg Ala Phe Val Arg  Lys Ser Ser Ile Leu  Ile Met Asp 
    1460                 1465                 1470             


Glu Ala  Thr Ala Ser Ile Asp  Met Ala Thr Glu Asn  Ile Leu Gln 
    1475                 1480                 1485             


Lys Val  Val Met Thr Ala Phe  Ala Asp Arg Thr Val  Val Thr Ile 
    1490                 1495                 1500             


Ala His  Arg Val Ser Ser Ile  Met Asp Ala Gly Leu  Val Leu Val 
    1505                 1510                 1515             


Phe Ser  Glu Gly Ile Leu Val  Glu Cys Asp Thr Val  Pro Asn Leu 
    1520                 1525                 1530             


Leu Ala  His Lys Asn Gly Leu  Phe Ser Thr Leu Val  Met Thr Asn 
    1535                 1540                 1545             


Lys 
    


<210>  61
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCD1__Homo_sapiens__NP_000024

<400>  61

Met Pro Val Leu Ser Arg Pro Arg Pro Trp Arg Gly Asn Thr Leu Lys 
1               5                   10                  15      


Arg Thr Ala Val Leu Leu Ala Leu Ala Ala Tyr Gly Ala His Lys Val 
            20                  25                  30          


Tyr Pro Leu Val Arg Gln Cys Leu Ala Pro Ala Arg Gly Leu Gln Ala 
        35                  40                  45              


Pro Ala Gly Glu Pro Thr Gln Glu Ala Ser Gly Val Ala Ala Ala Lys 
    50                  55                  60                  


Ala Gly Met Asn Arg Val Phe Leu Gln Arg Leu Leu Trp Leu Leu Arg 
65                  70                  75                  80  


Leu Leu Phe Pro Arg Val Leu Cys Arg Glu Thr Gly Leu Leu Ala Leu 
                85                  90                  95      


His Ser Ala Ala Leu Val Ser Arg Thr Phe Leu Ser Val Tyr Val Ala 
            100                 105                 110         


Arg Leu Asp Gly Arg Leu Ala Arg Cys Ile Val Arg Lys Asp Pro Arg 
        115                 120                 125             


Ala Phe Gly Trp Gln Leu Leu Gln Trp Leu Leu Ile Ala Leu Pro Ala 
    130                 135                 140                 


Thr Phe Val Asn Ser Ala Ile Arg Tyr Leu Glu Gly Gln Leu Ala Leu 
145                 150                 155                 160 


Ser Phe Arg Ser Arg Leu Val Ala His Ala Tyr Arg Leu Tyr Phe Ser 
                165                 170                 175     


Gln Gln Thr Tyr Tyr Arg Val Ser Asn Met Asp Gly Arg Leu Arg Asn 
            180                 185                 190         


Pro Asp Gln Ser Leu Thr Glu Asp Val Val Ala Phe Ala Ala Ser Val 
        195                 200                 205             


Ala His Leu Tyr Ser Asn Leu Thr Lys Pro Leu Leu Asp Val Ala Val 
    210                 215                 220                 


Thr Ser Tyr Thr Leu Leu Arg Ala Ala Arg Ser Arg Gly Ala Gly Thr 
225                 230                 235                 240 


Ala Trp Pro Ser Ala Ile Ala Gly Leu Val Val Phe Leu Thr Ala Asn 
                245                 250                 255     


Val Leu Arg Ala Phe Ser Pro Lys Phe Gly Glu Leu Val Ala Glu Glu 
            260                 265                 270         


Ala Arg Arg Lys Gly Glu Leu Arg Tyr Met His Ser Arg Val Val Ala 
        275                 280                 285             


Asn Ser Glu Glu Ile Ala Phe Tyr Gly Gly His Glu Val Glu Leu Ala 
    290                 295                 300                 


Leu Leu Gln Arg Ser Tyr Gln Asp Leu Ala Ser Gln Ile Asn Leu Ile 
305                 310                 315                 320 


Leu Leu Glu Arg Leu Trp Tyr Val Met Leu Glu Gln Phe Leu Met Lys 
                325                 330                 335     


Tyr Val Trp Ser Ala Ser Gly Leu Leu Met Val Ala Val Pro Ile Ile 
            340                 345                 350         


Thr Ala Thr Gly Tyr Ser Glu Ser Asp Ala Glu Ala Val Lys Lys Ala 
        355                 360                 365             


Ala Leu Glu Lys Lys Glu Glu Glu Leu Val Ser Glu Arg Thr Glu Ala 
    370                 375                 380                 


Phe Thr Ile Ala Arg Asn Leu Leu Thr Ala Ala Ala Asp Ala Ile Glu 
385                 390                 395                 400 


Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu Ala Gly Tyr Thr 
                405                 410                 415     


Ala Arg Val His Glu Met Phe Gln Val Phe Glu Asp Val Gln Arg Cys 
            420                 425                 430         


His Phe Lys Arg Pro Arg Glu Leu Glu Asp Ala Gln Ala Gly Ser Gly 
        435                 440                 445             


Thr Ile Gly Arg Ser Gly Val Arg Val Glu Gly Pro Leu Lys Ile Arg 
    450                 455                 460                 


Gly Gln Val Val Asp Val Glu Gln Gly Ile Ile Cys Glu Asn Ile Pro 
465                 470                 475                 480 


Ile Val Thr Pro Ser Gly Glu Val Val Val Ala Ser Leu Asn Ile Arg 
                485                 490                 495     


Val Glu Glu Gly Met His Leu Leu Ile Thr Gly Pro Asn Gly Cys Gly 
            500                 505                 510         


Lys Ser Ser Leu Phe Arg Ile Leu Gly Gly Leu Trp Pro Thr Tyr Gly 
        515                 520                 525             


Gly Val Leu Tyr Lys Pro Pro Pro Gln Arg Met Phe Tyr Ile Pro Gln 
    530                 535                 540                 


Arg Pro Tyr Met Ser Val Gly Ser Leu Arg Asp Gln Val Ile Tyr Pro 
545                 550                 555                 560 


Asp Ser Val Glu Asp Met Gln Arg Lys Gly Tyr Ser Glu Gln Asp Leu 
                565                 570                 575     


Glu Ala Ile Leu Asp Val Val His Leu His His Ile Leu Gln Arg Glu 
            580                 585                 590         


Gly Gly Trp Glu Ala Met Cys Asp Trp Lys Asp Val Leu Ser Gly Gly 
        595                 600                 605             


Glu Lys Gln Arg Ile Gly Met Ala Arg Met Phe Tyr His Arg Pro Lys 
    610                 615                 620                 


Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser Ile Asp Val Glu 
625                 630                 635                 640 


Gly Lys Ile Phe Gln Ala Ala Lys Asp Ala Gly Ile Ala Leu Leu Ser 
                645                 650                 655     


Ile Thr His Arg Pro Ser Leu Trp Lys Tyr His Thr His Leu Leu Gln 
            660                 665                 670         


Phe Asp Gly Glu Gly Gly Trp Lys Phe Glu Lys Leu Asp Ser Ala Ala 
        675                 680                 685             


Arg Leu Ser Leu Thr Glu Glu Lys Gln Arg Leu Glu Gln Gln Leu Ala 
    690                 695                 700                 


Gly Ile Pro Lys Met Gln Arg Arg Leu Gln Glu Leu Cys Gln Ile Leu 
705                 710                 715                 720 


Gly Glu Ala Val Ala Pro Ala His Val Pro Ala Pro Ser Pro Gln Gly 
                725                 730                 735     


Pro Gly Gly Leu Gln Gly Ala Ser Thr 
            740                 745 


<210>  62
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCD2__Homo_sapiens__XP_011536329

<400>  62

Met Thr His Met Leu Asn Ala Ala Ala Asp Arg Val Lys Trp Thr Arg 
1               5                   10                  15      


Ser Ser Ala Ala Lys Arg Ala Ala Cys Leu Val Ala Ala Ala Tyr Ala 
            20                  25                  30          


Leu Lys Thr Leu Tyr Pro Ile Ile Gly Lys Arg Leu Lys Gln Ser Gly 
        35                  40                  45              


His Gly Lys Lys Lys Ala Ala Ala Tyr Pro Ala Ala Glu Asn Thr Glu 
    50                  55                  60                  


Ile Leu His Cys Thr Glu Thr Ile Cys Glu Lys Pro Ser Pro Gly Val 
65                  70                  75                  80  


Asn Ala Asp Phe Phe Lys Gln Leu Leu Glu Leu Arg Lys Ile Leu Phe 
                85                  90                  95      


Pro Lys Leu Val Thr Thr Glu Thr Gly Trp Leu Cys Leu His Ser Val 
            100                 105                 110         


Ala Leu Ile Ser Arg Thr Phe Leu Ser Ile Tyr Val Ala Gly Leu Asp 
        115                 120                 125             


Gly Lys Ile Val Lys Ser Ile Val Glu Lys Lys Pro Arg Thr Phe Ile 
    130                 135                 140                 


Ile Lys Leu Ile Lys Trp Leu Met Ile Ala Ile Pro Ala Thr Phe Val 
145                 150                 155                 160 


Asn Ser Ala Ile Arg Tyr Leu Glu Cys Lys Leu Ala Leu Ala Phe Arg 
                165                 170                 175     


Thr Arg Leu Val Asp His Ala Tyr Glu Thr Tyr Phe Thr Asn Gln Thr 
            180                 185                 190         


Tyr Tyr Lys Val Ile Asn Met Asp Gly Arg Leu Ala Asn Pro Asp Gln 
        195                 200                 205             


Ser Leu Thr Glu Asp Ile Met Met Phe Ser Gln Ser Val Ala His Leu 
    210                 215                 220                 


Tyr Ser Asn Leu Thr Lys Pro Ile Leu Asp Val Met Leu Thr Ser Tyr 
225                 230                 235                 240 


Thr Leu Ile Gln Thr Ala Thr Ser Arg Gly Ala Ser Pro Ile Gly Pro 
                245                 250                 255     


Thr Leu Leu Ala Gly Leu Val Val Tyr Ala Thr Ala Lys Val Leu Lys 
            260                 265                 270         


Ala Cys Ser Pro Lys Phe Gly Lys Leu Val Ala Glu Glu Ala His Arg 
        275                 280                 285             


Lys Gly Tyr Leu Arg Tyr Val His Ser Arg Ile Ile Ala Asn Val Glu 
    290                 295                 300                 


Glu Ile Ala Phe Tyr Arg Gly His Lys Val Glu Met Lys Gln Leu Gln 
305                 310                 315                 320 


Lys Ser Tyr Lys Ala Leu Ala Asp Gln Met Asn Leu Ile Leu Ser Lys 
                325                 330                 335     


Arg Leu Trp Tyr Ile Met Ile Glu Gln Phe Leu Met Lys Tyr Val Trp 
            340                 345                 350         


Ser Ser Ser Gly Leu Ile Met Val Ala Ile Pro Ile Ile Thr Ala Thr 
        355                 360                 365             


Gly Phe Ala Asp Gly Glu Asp Gly Gln Lys Gln Val Met Val Ser Glu 
    370                 375                 380                 


Arg Thr Glu Ala Phe Thr Thr Ala Arg Asn Leu Leu Ala Ser Gly Ala 
385                 390                 395                 400 


Asp Ala Ile Glu Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu 
                405                 410                 415     


Ala Gly Tyr Thr Ala Arg Val Tyr Asn Met Phe Trp Val Phe Asp Glu 
            420                 425                 430         


Val Lys Arg Gly Ile Tyr Lys Arg Thr Ala Val Ile Gln Glu Ser Glu 
        435                 440                 445             


Ser His Ser Lys Asn Gly Ala Lys Val Glu Leu Pro Leu Ser Asp Thr 
    450                 455                 460                 


Leu Ala Ile Lys Gly Lys Val Ile Asp Val Asp His Gly Ile Ile Cys 
465                 470                 475                 480 


Glu Asn Val Pro Ile Ile Thr Pro Ala Gly Glu Val Val Ala Ser Arg 
                485                 490                 495     


Leu Asn Phe Lys Val Glu Glu Gly Met His Leu Leu Ile Thr Gly Pro 
            500                 505                 510         


Asn Gly Cys Gly Lys Ser Ser Leu Phe Arg Ile Leu Ser Gly Leu Trp 
        515                 520                 525             


Pro Val Tyr Glu Gly Val Leu Tyr Lys Pro Pro Pro Gln His Met Phe 
    530                 535                 540                 


Tyr Ile Pro Gln Arg Pro Tyr Met Ser Leu Gly Ser Leu Arg Asp Gln 
545                 550                 555                 560 


Val Ile Tyr Pro Asp Ser Val Asp Asp Met His Asp Lys Gly Tyr Thr 
                565                 570                 575     


Asp Gln Asp Leu Glu Arg Ile Leu His Asn Val His Leu Tyr His Ile 
            580                 585                 590         


Val Gln Arg Glu Gly Gly Trp Asp Ala Val Met Asp Trp Lys Asp Val 
        595                 600                 605             


Leu Ser Gly Gly Glu Lys Gln Arg Met Gly Met Ala Arg Met Phe Tyr 
    610                 615                 620                 


His Lys Pro Lys Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser 
625                 630                 635                 640 


Ile Asp Val Glu Gly Lys Ile Phe Gln Ala Ala Lys Gly Ala Gly Ile 
                645                 650                 655     


Ser Leu Leu Ser Ile Thr His Arg Pro Ser Leu Trp Lys Tyr His Thr 
            660                 665                 670         


His Leu Leu Gln Phe Asp Gly Glu Gly Gly Trp Arg Phe Glu Gln Leu 
        675                 680                 685             


Asp Thr Ala Ile Arg Leu Thr Leu Ser Glu Glu Lys Gln Lys Leu Glu 
    690                 695                 700                 


Ser Gln Leu Ala Gly Ile Pro Lys Met Gln Gln Arg Leu Asn Glu Leu 
705                 710                 715                 720 


Cys Lys Ile Leu Gly Glu Asp Ser Val Leu Lys Thr Ile Lys Asn Glu 
                725                 730                 735     


Asp Glu Thr Ser 
            740 


<210>  63
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCD3__Homo_sapiens__XP_011540179

<400>  63

Met Gly Phe Ile Asp Ser Ile Ile Ala Lys Tyr Leu Ala Thr Val Val 
1               5                   10                  15      


Gly Tyr Leu Val Val Ser Arg Pro Phe Leu Asp Leu Ser His Pro Arg 
            20                  25                  30          


His Leu Lys Ser Thr His Ser Glu Leu Leu Glu Asp Tyr Tyr Gln Ser 
        35                  40                  45              


Gly Arg Met Leu Leu Arg Met Ser Gln Ala Leu Gly Arg Ile Val Leu 
    50                  55                  60                  


Ala Gly Arg Glu Met Thr Arg Leu Ala Gly Phe Thr Ala Arg Ile Thr 
65                  70                  75                  80  


Glu Leu Met Gln Val Leu Lys Asp Leu Asn His Gly Lys Tyr Glu Arg 
                85                  90                  95      


Thr Met Val Ser Gln Gln Glu Lys Gly Ile Glu Gly Val Gln Val Ile 
            100                 105                 110         


Pro Leu Ile Pro Gly Ala Gly Glu Ile Ile Ile Ala Asp Asn Ile Ile 
        115                 120                 125             


Lys Phe Asp His Val Pro Leu Ala Thr Pro Asn Gly Asp Val Leu Ile 
    130                 135                 140                 


Arg Asp Leu Asn Phe Glu Val Arg Ser Gly Ala Asn Val Leu Ile Cys 
145                 150                 155                 160 


Gly Pro Asn Gly Cys Gly Lys Ser Ser Leu Phe Arg Val Leu Gly Glu 
                165                 170                 175     


Leu Trp Pro Leu Phe Gly Gly Arg Leu Thr Lys Pro Glu Arg Gly Lys 
            180                 185                 190         


Leu Phe Tyr Val Pro Gln Arg Pro Tyr Met Thr Leu Gly Thr Leu Arg 
        195                 200                 205             


Asp Gln Val Ile Tyr Pro Asp Gly Arg Glu Asp Gln Lys Arg Lys Gly 
    210                 215                 220                 


Ile Ser Asp Leu Val Leu Lys Glu Tyr Leu Asp Asn Val Gln Leu Gly 
225                 230                 235                 240 


His Ile Leu Glu Arg Glu Gly Gly Trp Asp Ser Val Gln Asp Trp Met 
                245                 250                 255     


Asp Val Leu Ser Gly Gly Glu Lys Gln Arg Met Ala Met Ala Arg Leu 
            260                 265                 270         


Phe Tyr His Lys Pro Gln Phe Ala Ile Leu Asp Glu Cys Thr Ser Ala 
        275                 280                 285             


Val Ser Val Asp Val Glu Gly Tyr Ile Tyr Ser His Cys Arg Lys Val 
    290                 295                 300                 


Gly Ile Thr Leu Phe Thr Val Ser His Arg Lys Ser Leu Trp Lys His 
305                 310                 315                 320 


His Glu Tyr Tyr Leu His Met Asp Gly Arg Gly Asn Tyr Glu Phe Lys 
                325                 330                 335     


Gln Ile Thr Glu Asp Thr Val Glu Phe Gly Ser 
            340                 345         


<210>  64
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCD4__Homo_sapiens__NP_005041

<400>  64

Met Ala Val Ala Gly Pro Ala Pro Gly Ala Gly Ala Arg Pro Arg Leu 
1               5                   10                  15      


Asp Leu Gln Phe Leu Gln Arg Phe Leu Gln Ile Leu Lys Val Leu Phe 
            20                  25                  30          


Pro Ser Trp Ser Ser Gln Asn Ala Leu Met Phe Leu Thr Leu Leu Cys 
        35                  40                  45              


Leu Thr Leu Leu Glu Gln Phe Val Ile Tyr Gln Val Gly Leu Ile Pro 
    50                  55                  60                  


Ser Gln Tyr Tyr Gly Val Leu Gly Asn Lys Asp Leu Glu Gly Phe Lys 
65                  70                  75                  80  


Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr Leu 
                85                  90                  95      


Lys Ser Phe Asp Gln Phe Thr Cys Asn Leu Leu Tyr Val Ser Trp Arg 
            100                 105                 110         


Lys Asp Leu Thr Glu His Leu His Arg Leu Tyr Phe Arg Gly Arg Ala 
        115                 120                 125             


Tyr Tyr Thr Leu Asn Val Leu Arg Asp Asp Ile Asp Asn Pro Asp Gln 
    130                 135                 140                 


Arg Ile Ser Gln Asp Val Glu Arg Phe Cys Arg Gln Leu Ser Ser Met 
145                 150                 155                 160 


Ala Ser Lys Leu Ile Ile Ser Pro Phe Thr Leu Val Tyr Tyr Thr Tyr 
                165                 170                 175     


Gln Cys Phe Gln Ser Thr Gly Trp Leu Gly Pro Val Ser Ile Phe Gly 
            180                 185                 190         


Tyr Phe Ile Leu Gly Thr Val Val Asn Lys Thr Leu Met Gly Pro Ile 
        195                 200                 205             


Val Met Lys Leu Val His Gln Glu Lys Leu Glu Gly Asp Phe Arg Phe 
    210                 215                 220                 


Lys His Met Gln Ile Arg Val Asn Ala Glu Pro Ala Ala Phe Tyr Arg 
225                 230                 235                 240 


Ala Gly His Val Glu His Met Arg Thr Asp Arg Arg Leu Gln Arg Leu 
                245                 250                 255     


Leu Gln Thr Gln Arg Glu Leu Met Ser Lys Glu Leu Trp Leu Tyr Ile 
            260                 265                 270         


Gly Ile Asn Thr Phe Asp Tyr Leu Gly Ser Ile Leu Ser Tyr Val Val 
        275                 280                 285             


Ile Ala Ile Pro Ile Phe Ser Gly Val Tyr Gly Asp Leu Ser Pro Ala 
    290                 295                 300                 


Glu Leu Ser Thr Leu Val Ser Lys Asn Ala Phe Val Cys Ile Tyr Leu 
305                 310                 315                 320 


Ile Ser Cys Phe Thr Gln Leu Ile Asp Leu Ser Thr Thr Leu Ser Asp 
                325                 330                 335     


Val Ala Gly Tyr Thr His Arg Ile Gly Gln Leu Arg Glu Thr Leu Leu 
            340                 345                 350         


Asp Met Ser Leu Lys Ser Gln Asp Cys Glu Ile Leu Gly Glu Ser Glu 
        355                 360                 365             


Trp Gly Leu Asp Thr Pro Pro Gly Trp Pro Ala Ala Glu Pro Ala Asp 
    370                 375                 380                 


Thr Ala Phe Leu Leu Glu Arg Val Ser Ile Ser Ala Pro Ser Ser Asp 
385                 390                 395                 400 


Lys Pro Leu Ile Lys Asp Leu Ser Leu Lys Ile Ser Glu Gly Gln Ser 
                405                 410                 415     


Leu Leu Ile Thr Gly Asn Thr Gly Thr Gly Lys Thr Ser Leu Leu Arg 
            420                 425                 430         


Val Leu Gly Gly Leu Trp Thr Ser Thr Arg Gly Ser Val Gln Met Leu 
        435                 440                 445             


Thr Asp Phe Gly Pro His Gly Val Leu Phe Leu Pro Gln Lys Pro Phe 
    450                 455                 460                 


Phe Thr Asp Gly Thr Leu Arg Glu Gln Val Ile Tyr Pro Leu Lys Glu 
465                 470                 475                 480 


Val Tyr Pro Asp Ser Gly Ser Ala Asp Asp Glu Arg Ile Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Ala Gly Leu Ser Asn Leu Val Ala Arg Thr Glu Gly Leu 
            500                 505                 510         


Asp Gln Gln Val Asp Trp Asn Trp Tyr Asp Val Leu Ser Pro Gly Glu 
        515                 520                 525             


Met Gln Arg Leu Ser Phe Ala Arg Leu Phe Tyr Leu Gln Pro Lys Tyr 
    530                 535                 540                 


Ala Val Leu Asp Glu Ala Thr Ser Ala Leu Thr Glu Glu Val Glu Ser 
545                 550                 555                 560 


Glu Leu Tyr Arg Ile Gly Gln Gln Leu Gly Met Thr Phe Ile Ser Val 
                565                 570                 575     


Gly His Arg Gln Ser Leu Glu Lys Phe His Ser Leu Val Leu Lys Leu 
            580                 585                 590         


Cys Gly Gly Gly Arg Trp Glu Leu Met Arg Ile Lys Val Glu 
        595                 600                 605     


<210>  65
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCE1__Homo_sapiens__NP_002931

<400>  65

Met Ala Asp Lys Leu Thr Arg Ile Ala Ile Val Asn His Asp Lys Cys 
1               5                   10                  15      


Lys Pro Lys Lys Cys Arg Gln Glu Cys Lys Lys Ser Cys Pro Val Val 
            20                  25                  30          


Arg Met Gly Lys Leu Cys Ile Glu Val Thr Pro Gln Ser Lys Ile Ala 
        35                  40                  45              


Trp Ile Ser Glu Thr Leu Cys Ile Gly Cys Gly Ile Cys Ile Lys Lys 
    50                  55                  60                  


Cys Pro Phe Gly Ala Leu Ser Ile Val Asn Leu Pro Ser Asn Leu Glu 
65                  70                  75                  80  


Lys Glu Thr Thr His Arg Tyr Cys Ala Asn Ala Phe Lys Leu His Arg 
                85                  90                  95      


Leu Pro Ile Pro Arg Pro Gly Glu Val Leu Gly Leu Val Gly Thr Asn 
            100                 105                 110         


Gly Ile Gly Lys Ser Thr Ala Leu Lys Ile Leu Ala Gly Lys Gln Lys 
        115                 120                 125             


Pro Asn Leu Gly Lys Tyr Asp Asp Pro Pro Asp Trp Gln Glu Ile Leu 
    130                 135                 140                 


Thr Tyr Phe Arg Gly Ser Glu Leu Gln Asn Tyr Phe Thr Lys Ile Leu 
145                 150                 155                 160 


Glu Asp Asp Leu Lys Ala Ile Ile Lys Pro Gln Tyr Val Asp Gln Ile 
                165                 170                 175     


Pro Lys Ala Ala Lys Gly Thr Val Gly Ser Ile Leu Asp Arg Lys Asp 
            180                 185                 190         


Glu Thr Lys Thr Gln Ala Ile Val Cys Gln Gln Leu Asp Leu Thr His 
        195                 200                 205             


Leu Lys Glu Arg Asn Val Glu Asp Leu Ser Gly Gly Glu Leu Gln Arg 
    210                 215                 220                 


Phe Ala Cys Ala Val Val Cys Ile Gln Lys Ala Asp Ile Phe Met Phe 
225                 230                 235                 240 


Asp Glu Pro Ser Ser Tyr Leu Asp Val Lys Gln Arg Leu Lys Ala Ala 
                245                 250                 255     


Ile Thr Ile Arg Ser Leu Ile Asn Pro Asp Arg Tyr Ile Ile Val Val 
            260                 265                 270         


Glu His Asp Leu Ser Val Leu Asp Tyr Leu Ser Asp Phe Ile Cys Cys 
        275                 280                 285             


Leu Tyr Gly Val Pro Ser Ala Tyr Gly Val Val Thr Met Pro Phe Ser 
    290                 295                 300                 


Val Arg Glu Gly Ile Asn Ile Phe Leu Asp Gly Tyr Val Pro Thr Glu 
305                 310                 315                 320 


Asn Leu Arg Phe Arg Asp Ala Ser Leu Val Phe Lys Val Ala Glu Thr 
                325                 330                 335     


Ala Asn Glu Glu Glu Val Lys Lys Met Cys Met Tyr Lys Tyr Pro Gly 
            340                 345                 350         


Met Lys Lys Lys Met Gly Glu Phe Glu Leu Ala Ile Val Ala Gly Glu 
        355                 360                 365             


Phe Thr Asp Ser Glu Ile Met Val Met Leu Gly Glu Asn Gly Thr Gly 
    370                 375                 380                 


Lys Thr Thr Phe Ile Arg Met Leu Ala Gly Arg Leu Lys Pro Asp Glu 
385                 390                 395                 400 


Gly Gly Glu Val Pro Val Leu Asn Val Ser Tyr Lys Pro Gln Lys Ile 
                405                 410                 415     


Ser Pro Lys Ser Thr Gly Ser Val Arg Gln Leu Leu His Glu Lys Ile 
            420                 425                 430         


Arg Asp Ala Tyr Thr His Pro Gln Phe Val Thr Asp Val Met Lys Pro 
        435                 440                 445             


Leu Gln Ile Glu Asn Ile Ile Asp Gln Glu Val Gln Thr Leu Ser Gly 
    450                 455                 460                 


Gly Glu Leu Gln Arg Val Ala Leu Ala Leu Cys Leu Gly Lys Pro Ala 
465                 470                 475                 480 


Asp Val Tyr Leu Ile Asp Glu Pro Ser Ala Tyr Leu Asp Ser Glu Gln 
                485                 490                 495     


Arg Leu Met Ala Ala Arg Val Val Lys Arg Phe Ile Leu His Ala Lys 
            500                 505                 510         


Lys Thr Ala Phe Val Val Glu His Asp Phe Ile Met Ala Thr Tyr Leu 
        515                 520                 525             


Ala Asp Arg Val Ile Val Phe Asp Gly Val Pro Ser Lys Asn Thr Val 
    530                 535                 540                 


Ala Asn Ser Pro Gln Thr Leu Leu Ala Gly Met Asn Lys Phe Leu Ser 
545                 550                 555                 560 


Gln Leu Glu Ile Thr Phe Arg Arg Asp Pro Asn Asn Tyr Arg Pro Arg 
                565                 570                 575     


Ile Asn Lys Leu Asn Ser Ile Lys Asp Val Glu Gln Lys Lys Ser Gly 
            580                 585                 590         


Asn Tyr Phe Phe Leu Asp Asp 
        595                 


<210>  66
<211>  845
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCF1__Homo_sapiens__NP_001020262

<400>  66

Met Pro Lys Ala Pro Lys Gln Gln Pro Pro Glu Pro Glu Trp Ile Gly 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ser Pro Ser Asp Lys Val Val Lys Lys Gly Lys 
            20                  25                  30          


Lys Asp Lys Lys Ile Lys Lys Thr Phe Phe Glu Glu Leu Ala Val Glu 
        35                  40                  45              


Asp Lys Gln Ala Gly Glu Glu Glu Lys Val Leu Lys Glu Lys Glu Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Lys Lys Arg Asp Thr Arg 
65                  70                  75                  80  


Lys Gly Arg Arg Lys Lys Asp Val Asp Asp Asp Gly Glu Glu Lys Glu 
                85                  90                  95      


Leu Met Glu Arg Leu Lys Lys Leu Ser Val Pro Thr Ser Asp Glu Glu 
            100                 105                 110         


Asp Glu Val Pro Ala Pro Lys Pro Arg Gly Gly Lys Lys Thr Lys Gly 
        115                 120                 125             


Gly Asn Val Phe Ala Ala Leu Ile Gln Asp Gln Ser Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Lys His Pro Pro Lys Pro Ala Lys Pro Glu Lys Asn Arg 
145                 150                 155                 160 


Ile Asn Lys Ala Val Ser Glu Glu Gln Gln Pro Ala Leu Lys Gly Lys 
                165                 170                 175     


Lys Gly Lys Glu Glu Lys Ser Lys Gly Lys Ala Lys Pro Gln Asn Lys 
            180                 185                 190         


Phe Ala Ala Leu Asp Asn Glu Glu Glu Asp Lys Glu Glu Glu Ile Ile 
        195                 200                 205             


Lys Glu Lys Glu Pro Pro Lys Gln Gly Lys Glu Lys Ala Lys Lys Ala 
    210                 215                 220                 


Glu Gln Gly Ser Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Gly Gly Glu Ser Lys Ala Asp Asp Pro Tyr Ala His Leu Ser Lys Lys 
                245                 250                 255     


Glu Lys Lys Lys Leu Lys Lys Gln Met Glu Tyr Glu Arg Gln Val Ala 
            260                 265                 270         


Ser Leu Lys Ala Ala Asn Ala Ala Glu Asn Asp Phe Ser Val Ser Gln 
        275                 280                 285             


Ala Glu Met Ser Ser Arg Gln Ala Met Leu Glu Asn Ala Ser Asp Ile 
    290                 295                 300                 


Lys Leu Glu Lys Phe Ser Ile Ser Ala His Gly Lys Glu Leu Phe Val 
305                 310                 315                 320 


Asn Ala Asp Leu Tyr Ile Val Ala Gly Arg Arg Tyr Gly Leu Val Gly 
                325                 330                 335     


Pro Asn Gly Lys Gly Lys Thr Thr Leu Leu Lys His Ile Ala Asn Arg 
            340                 345                 350         


Ala Leu Ser Ile Pro Pro Asn Ile Asp Val Leu Leu Cys Glu Gln Glu 
        355                 360                 365             


Val Val Ala Asp Glu Thr Pro Ala Val Gln Ala Val Leu Arg Ala Asp 
    370                 375                 380                 


Thr Lys Arg Leu Lys Leu Leu Glu Glu Glu Arg Arg Leu Gln Gly Gln 
385                 390                 395                 400 


Leu Glu Gln Gly Asp Asp Thr Ala Ala Glu Arg Leu Glu Lys Val Tyr 
                405                 410                 415     


Glu Glu Leu Arg Ala Thr Gly Ala Ala Ala Ala Glu Ala Lys Ala Arg 
            420                 425                 430         


Arg Ile Leu Ala Gly Leu Gly Phe Asp Pro Glu Met Gln Asn Arg Pro 
        435                 440                 445             


Thr Gln Lys Phe Ser Gly Gly Trp Arg Met Arg Val Ser Leu Ala Arg 
    450                 455                 460                 


Ala Leu Phe Met Glu Pro Thr Leu Leu Met Leu Asp Glu Pro Thr Asn 
465                 470                 475                 480 


His Leu Asp Leu Asn Ala Val Ile Trp Leu Asn Asn Tyr Leu Gln Gly 
                485                 490                 495     


Trp Arg Lys Thr Leu Leu Ile Val Ser His Asp Gln Gly Phe Leu Asp 
            500                 505                 510         


Asp Val Cys Thr Asp Ile Ile His Leu Asp Ala Gln Arg Leu His Tyr 
        515                 520                 525             


Tyr Arg Gly Asn Tyr Met Thr Phe Lys Lys Met Tyr Gln Gln Lys Gln 
    530                 535                 540                 


Lys Glu Leu Leu Lys Gln Tyr Glu Lys Gln Glu Lys Lys Leu Lys Glu 
545                 550                 555                 560 


Leu Lys Ala Gly Gly Lys Ser Thr Lys Gln Ala Glu Lys Gln Thr Lys 
                565                 570                 575     


Glu Ala Leu Thr Arg Lys Gln Gln Lys Cys Arg Arg Lys Asn Gln Asp 
            580                 585                 590         


Glu Glu Ser Gln Glu Ala Pro Glu Leu Leu Lys Arg Pro Lys Glu Tyr 
        595                 600                 605             


Thr Val Arg Phe Thr Phe Pro Asp Pro Pro Pro Leu Ser Pro Pro Val 
    610                 615                 620                 


Leu Gly Leu His Gly Val Thr Phe Gly Tyr Gln Gly Gln Lys Pro Leu 
625                 630                 635                 640 


Phe Lys Asn Leu Asp Phe Gly Ile Asp Met Asp Ser Arg Ile Cys Ile 
                645                 650                 655     


Val Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Leu Leu Leu Leu Thr 
            660                 665                 670         


Gly Lys Leu Thr Pro Thr His Gly Glu Met Arg Lys Asn His Arg Leu 
        675                 680                 685             


Lys Ile Gly Phe Phe Asn Gln Gln Tyr Ala Glu Gln Leu Arg Met Glu 
    690                 695                 700                 


Glu Thr Pro Thr Glu Tyr Leu Gln Arg Gly Phe Asn Leu Pro Tyr Gln 
705                 710                 715                 720 


Asp Ala Arg Lys Cys Leu Gly Arg Phe Gly Leu Glu Ser His Ala His 
                725                 730                 735     


Thr Ile Gln Ile Cys Lys Leu Ser Gly Gly Gln Lys Ala Arg Val Val 
            740                 745                 750         


Phe Ala Glu Leu Ala Cys Arg Glu Pro Asp Val Leu Ile Leu Asp Glu 
        755                 760                 765             


Pro Thr Asn Asn Leu Asp Ile Glu Ser Ile Asp Ala Leu Gly Glu Ala 
    770                 775                 780                 


Ile Asn Glu Tyr Lys Gly Ala Val Ile Val Val Ser His Asp Ala Arg 
785                 790                 795                 800 


Leu Ile Thr Glu Thr Asn Cys Gln Leu Trp Val Val Glu Glu Gln Ser 
                805                 810                 815     


Val Ser Gln Ile Asp Gly Asp Phe Glu Asp Tyr Lys Arg Glu Val Leu 
            820                 825                 830         


Glu Ala Leu Gly Glu Val Met Val Ser Arg Pro Arg Glu 
        835                 840                 845 


<210>  67
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCF2__Homo_sapiens__NP_005683

<400>  67

Met Pro Ser Asp Leu Ala Lys Lys Lys Ala Ala Lys Lys Lys Glu Ala 
1               5                   10                  15      


Ala Lys Ala Arg Gln Arg Pro Arg Lys Gly His Glu Glu Asn Gly Asp 
            20                  25                  30          


Val Val Thr Glu Pro Gln Val Ala Glu Lys Asn Glu Ala Asn Gly Arg 
        35                  40                  45              


Glu Thr Thr Glu Val Asp Leu Leu Thr Lys Glu Leu Glu Asp Phe Glu 
    50                  55                  60                  


Met Lys Lys Ala Ala Ala Arg Ala Val Thr Gly Val Leu Ala Ser His 
65                  70                  75                  80  


Pro Asn Ser Thr Asp Val His Ile Ile Asn Leu Ser Leu Thr Phe His 
                85                  90                  95      


Gly Gln Glu Leu Leu Ser Asp Thr Lys Leu Glu Leu Asn Ser Gly Arg 
            100                 105                 110         


Arg Tyr Gly Leu Ile Gly Leu Asn Gly Ile Gly Lys Ser Met Leu Leu 
        115                 120                 125             


Ser Ala Ile Gly Lys Arg Glu Val Pro Ile Pro Glu His Ile Asp Ile 
    130                 135                 140                 


Tyr His Leu Thr Arg Glu Met Pro Pro Ser Asp Lys Thr Pro Leu His 
145                 150                 155                 160 


Cys Val Met Glu Val Asp Thr Glu Arg Ala Met Leu Glu Lys Glu Ala 
                165                 170                 175     


Glu Arg Leu Ala His Glu Asp Ala Glu Cys Glu Lys Leu Met Glu Leu 
            180                 185                 190         


Tyr Glu Arg Leu Glu Glu Leu Asp Ala Asp Lys Ala Glu Met Arg Ala 
        195                 200                 205             


Ser Arg Ile Leu His Gly Leu Gly Phe Thr Pro Ala Met Gln Arg Lys 
    210                 215                 220                 


Lys Leu Lys Asp Phe Ser Gly Gly Trp Arg Met Arg Val Ala Leu Ala 
225                 230                 235                 240 


Arg Ala Leu Phe Ile Arg Pro Phe Met Leu Leu Leu Asp Glu Pro Thr 
                245                 250                 255     


Asn His Leu Asp Leu Asp Ala Cys Val Trp Leu Glu Glu Glu Leu Lys 
            260                 265                 270         


Thr Phe Lys Arg Ile Leu Val Leu Val Ser His Ser Gln Asp Phe Leu 
        275                 280                 285             


Asn Gly Val Cys Thr Asn Ile Ile His Met His Asn Lys Lys Leu Lys 
    290                 295                 300                 


Tyr Tyr Thr Gly Asn Tyr Asp Gln Tyr Val Lys Thr Arg Leu Glu Leu 
305                 310                 315                 320 


Glu Glu Asn Gln Met Lys Arg Phe His Trp Glu Gln Asp Gln Ile Ala 
                325                 330                 335     


His Met Lys Asn Tyr Ile Ala Arg Phe Gly His Gly Ser Ala Lys Leu 
            340                 345                 350         


Ala Arg Gln Ala Gln Ser Lys Glu Lys Thr Leu Gln Lys Met Met Ala 
        355                 360                 365             


Ser Gly Leu Thr Glu Arg Val Val Ser Asp Lys Thr Leu Ser Phe Tyr 
    370                 375                 380                 


Phe Pro Pro Cys Gly Lys Ile Pro Pro Pro Val Ile Met Val Gln Asn 
385                 390                 395                 400 


Val Ser Phe Lys Tyr Thr Lys Asp Gly Pro Cys Ile Tyr Asn Asn Leu 
                405                 410                 415     


Glu Phe Gly Ile Asp Leu Asp Thr Arg Val Ala Leu Val Gly Pro Asn 
            420                 425                 430         


Gly Ala Gly Lys Ser Thr Leu Leu Lys Leu Leu Thr Gly Glu Leu Leu 
        435                 440                 445             


Pro Thr Asp Gly Met Ile Arg Lys His Ser His Val Lys Ile Gly Arg 
    450                 455                 460                 


Tyr His Gln His Leu Gln Glu Gln Leu Asp Leu Asp Leu Ser Pro Leu 
465                 470                 475                 480 


Glu Tyr Met Met Lys Cys Tyr Pro Glu Ile Lys Glu Lys Glu Glu Met 
                485                 490                 495     


Arg Lys Ile Ile Gly Arg Tyr Gly Leu Thr Gly Lys Gln Gln Val Ser 
            500                 505                 510         


Pro Ile Arg Asn Leu Ser Asp Gly Gln Lys Cys Arg Val Cys Leu Ala 
        515                 520                 525             


Trp Leu Ala Trp Gln Asn Pro His Met Leu Phe Leu Asp Glu Pro Thr 
    530                 535                 540                 


Asn His Leu Asp Ile Glu Thr Ile Asp Ala Leu Ala Asp Ala Ile Asn 
545                 550                 555                 560 


Glu Phe Glu Gly Gly Met Met Leu Val Ser His Asp Phe Arg Leu Ile 
                565                 570                 575     


Gln Gln Val Ala Gln Glu Ile Trp Val Cys Glu Lys Gln Thr Ile Thr 
            580                 585                 590         


Lys Trp Pro Gly Asp Ile Leu Ala Tyr Lys Glu His Leu Lys Ser Lys 
        595                 600                 605             


Leu Val Asp Glu Glu Pro Gln Leu Thr Lys Arg Thr His Asn Val Cys 
    610                 615                 620                 


Thr Leu Thr Leu Ala Ser Leu Pro Arg Pro 
625                 630                 


<210>  68
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCG1__Homo_sapiens__NP_004906

<400>  68

Met Ala Cys Leu Met Ala Ala Phe Ser Val Gly Thr Ala Met Asn Ala 
1               5                   10                  15      


Ser Ser Tyr Ser Ala Glu Met Thr Glu Pro Lys Ser Val Cys Val Ser 
            20                  25                  30          


Val Asp Glu Val Val Ser Ser Asn Met Glu Ala Thr Glu Thr Asp Leu 
        35                  40                  45              


Leu Asn Gly His Leu Lys Lys Val Asp Asn Asn Leu Thr Glu Ala Gln 
    50                  55                  60                  


Arg Phe Ser Ser Leu Pro Arg Arg Ala Ala Val Asn Ile Glu Phe Arg 
65                  70                  75                  80  


Asp Leu Ser Tyr Ser Val Pro Glu Gly Pro Trp Trp Arg Lys Lys Gly 
                85                  90                  95      


Tyr Lys Thr Leu Leu Lys Gly Ile Ser Gly Lys Phe Asn Ser Gly Glu 
            100                 105                 110         


Leu Val Ala Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Leu Met 
        115                 120                 125             


Asn Ile Leu Ala Gly Tyr Arg Glu Thr Gly Met Lys Gly Ala Val Leu 
    130                 135                 140                 


Ile Asn Gly Leu Pro Arg Asp Leu Arg Cys Phe Arg Lys Val Ser Cys 
145                 150                 155                 160 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Gln Glu 
                165                 170                 175     


Ala Met Met Val Ser Ala His Leu Lys Leu Gln Glu Lys Asp Glu Gly 
            180                 185                 190         


Arg Arg Glu Met Val Lys Glu Ile Leu Thr Ala Leu Gly Leu Leu Ser 
        195                 200                 205             


Cys Ala Asn Thr Arg Thr Gly Ser Leu Ser Gly Gly Gln Arg Lys Arg 
    210                 215                 220                 


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
225                 230                 235                 240 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
                245                 250                 255     


Ser Leu Met Lys Gly Leu Ala Gln Gly Gly Arg Ser Ile Ile Cys Thr 
            260                 265                 270         


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Leu Phe Asp Gln Leu Tyr 
        275                 280                 285             


Val Leu Ser Gln Gly Gln Cys Val Tyr Arg Gly Lys Val Cys Asn Leu 
    290                 295                 300                 


Val Pro Tyr Leu Arg Asp Leu Gly Leu Asn Cys Pro Thr Tyr His Asn 
305                 310                 315                 320 


Pro Ala Asp Phe Val Met Glu Val Ala Ser Gly Glu Tyr Gly Asp Gln 
                325                 330                 335     


Asn Ser Arg Leu Val Arg Ala Val Arg Glu Gly Met Cys Asp Ser Asp 
            340                 345                 350         


His Lys Arg Asp Leu Gly Gly Asp Ala Glu Val Asn Pro Phe Leu Trp 
        355                 360                 365             


His Arg Pro Ser Glu Glu Val Lys Gln Thr Lys Arg Leu Lys Gly Leu 
    370                 375                 380                 


Arg Lys Asp Ser Ser Ser Met Glu Gly Cys His Ser Phe Ser Ala Ser 
385                 390                 395                 400 


Cys Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser Ile 
                405                 410                 415     


Met Arg Asp Ser Val Leu Thr His Leu Arg Ile Thr Ser His Ile Gly 
            420                 425                 430         


Ile Gly Leu Leu Ile Gly Leu Leu Tyr Leu Gly Ile Gly Asn Glu Ala 
        435                 440                 445             


Lys Lys Val Leu Ser Asn Ser Gly Phe Leu Phe Phe Ser Met Leu Phe 
    450                 455                 460                 


Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu Glu 
465                 470                 475                 480 


Met Gly Val Phe Leu Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu Lys 
                485                 490                 495     


Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Ile Met 
            500                 505                 510         


Phe Pro Val Ala Tyr Cys Ser Ile Val Tyr Trp Met Thr Ser Gln Pro 
        515                 520                 525             


Ser Asp Ala Val Arg Phe Val Leu Phe Ala Ala Leu Gly Thr Met Thr 
    530                 535                 540                 


Ser Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser Thr 
545                 550                 555                 560 


Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro Val 
                565                 570                 575     


Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Asp Thr Ile Pro Thr Tyr 
            580                 585                 590         


Leu Gln Trp Met Ser Tyr Ile Ser Tyr Val Arg Tyr Gly Phe Glu Gly 
        595                 600                 605             


Val Ile Leu Ser Ile Tyr Gly Leu Asp Arg Glu Asp Leu His Cys Asp 
    610                 615                 620                 


Ile Asp Glu Thr Cys His Phe Gln Lys Ser Glu Ala Ile Leu Arg Glu 
625                 630                 635                 640 


Leu Asp Val Glu Asn Ala Lys Leu Tyr Leu Asp Phe Ile Val Leu Gly 
                645                 650                 655     


Ile Phe Phe Ile Ser Leu Arg Leu Ile Ala Tyr Phe Val Leu Arg Tyr 
            660                 665                 670         


Lys Ile Arg Ala Glu Arg 
        675             


<210>  69
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCG2__Homo_sapiens__NP_001244315

<400>  69

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Val Cys Trp Ser Ile Ser Gln Pro Leu His Leu 
545                 550                 555                 560 


Gly Cys His Gly Phe Ser Thr Ser Ala Phe His Asp Met Asp Leu Arg 
                565                 570                 575     


Leu Cys Ser Ile Met Asn Phe Trp Asp Lys Thr Ser Ala Gln Asp Ser 
            580                 585                 590         


Met Gln Gln Glu Thr Ile Leu Val Thr Met Gln His Val Leu Ala Lys 
        595                 600                 605             


Asn Ile Trp 
    610     


<210>  70
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCG4__Homo_sapiens__NP_001135977

<400>  70

Met Ala Glu Lys Ala Leu Glu Ala Val Gly Cys Gly Leu Gly Pro Gly 
1               5                   10                  15      


Ala Val Ala Met Ala Val Thr Leu Glu Asp Gly Ala Glu Pro Pro Val 
            20                  25                  30          


Leu Thr Thr His Leu Lys Lys Val Glu Asn His Ile Thr Glu Ala Gln 
        35                  40                  45              


Arg Phe Ser His Leu Pro Lys Arg Ser Ala Val Asp Ile Glu Phe Val 
    50                  55                  60                  


Glu Leu Ser Tyr Ser Val Arg Glu Gly Pro Cys Trp Arg Lys Arg Gly 
65                  70                  75                  80  


Tyr Lys Thr Leu Leu Lys Cys Leu Ser Gly Lys Phe Cys Arg Arg Glu 
                85                  90                  95      


Leu Ile Gly Ile Met Gly Pro Ser Gly Ala Gly Lys Ser Thr Phe Met 
            100                 105                 110         


Asn Ile Leu Ala Gly Tyr Arg Glu Ser Gly Met Lys Gly Gln Ile Leu 
        115                 120                 125             


Val Asn Gly Arg Pro Arg Glu Leu Arg Thr Phe Arg Lys Met Ser Cys 
    130                 135                 140                 


Tyr Ile Met Gln Asp Asp Met Leu Leu Pro His Leu Thr Val Leu Glu 
145                 150                 155                 160 


Ala Met Met Val Ser Ala Asn Leu Lys Leu Ser Glu Lys Gln Glu Val 
                165                 170                 175     


Lys Lys Glu Leu Val Thr Glu Ile Leu Thr Ala Leu Gly Leu Met Ser 
            180                 185                 190         


Cys Ser His Thr Arg Thr Ala Leu Leu Ser Gly Gly Gln Arg Lys Arg 
        195                 200                 205             


Leu Ala Ile Ala Leu Glu Leu Val Asn Asn Pro Pro Val Met Phe Phe 
    210                 215                 220                 


Asp Glu Pro Thr Ser Gly Leu Asp Ser Ala Ser Cys Phe Gln Val Val 
225                 230                 235                 240 


Ser Leu Met Lys Ser Leu Ala Gln Gly Gly Arg Thr Ile Ile Cys Thr 
                245                 250                 255     


Ile His Gln Pro Ser Ala Lys Leu Phe Glu Met Phe Asp Lys Leu Tyr 
            260                 265                 270         


Ile Leu Ser Gln Gly Gln Cys Ile Phe Lys Gly Val Val Thr Asn Leu 
        275                 280                 285             


Ile Pro Tyr Leu Lys Gly Leu Gly Leu His Cys Pro Thr Tyr His Asn 
    290                 295                 300                 


Pro Ala Asp Phe Ile Ile Glu Val Ala Ser Gly Glu Tyr Gly Asp Leu 
305                 310                 315                 320 


Asn Pro Met Leu Phe Arg Ala Val Gln Asn Gly Leu Cys Ala Met Ala 
                325                 330                 335     


Glu Lys Lys Ser Ser Pro Glu Lys Asn Glu Val Pro Ala Pro Cys Pro 
            340                 345                 350         


Pro Cys Pro Pro Glu Val Asp Pro Ile Glu Ser His Thr Phe Ala Thr 
        355                 360                 365             


Ser Thr Leu Thr Gln Phe Cys Ile Leu Phe Lys Arg Thr Phe Leu Ser 
    370                 375                 380                 


Ile Leu Arg Asp Thr Val Leu Thr His Leu Arg Phe Met Ser His Val 
385                 390                 395                 400 


Val Ile Gly Val Leu Ile Gly Leu Leu Tyr Leu His Ile Gly Asp Asp 
                405                 410                 415     


Ala Ser Lys Val Phe Asn Asn Thr Gly Cys Leu Phe Phe Ser Met Leu 
            420                 425                 430         


Phe Leu Met Phe Ala Ala Leu Met Pro Thr Val Leu Thr Phe Pro Leu 
        435                 440                 445             


Glu Met Ala Val Phe Met Arg Glu His Leu Asn Tyr Trp Tyr Ser Leu 
    450                 455                 460                 


Lys Ala Tyr Tyr Leu Ala Lys Thr Met Ala Asp Val Pro Phe Gln Val 
465                 470                 475                 480 


Val Cys Pro Val Val Tyr Cys Ser Ile Val Tyr Trp Met Thr Gly Gln 
                485                 490                 495     


Pro Ala Glu Thr Ser Arg Phe Leu Leu Phe Ser Ala Leu Ala Thr Ala 
            500                 505                 510         


Thr Ala Leu Val Ala Gln Ser Leu Gly Leu Leu Ile Gly Ala Ala Ser 
        515                 520                 525             


Asn Ser Leu Gln Val Ala Thr Phe Val Gly Pro Val Thr Ala Ile Pro 
    530                 535                 540                 


Val Leu Leu Phe Ser Gly Phe Phe Val Ser Phe Lys Thr Ile Pro Thr 
545                 550                 555                 560 


Tyr Leu Gln Trp Ser Ser Tyr Leu Ser Tyr Val Arg Tyr Gly Phe Glu 
                565                 570                 575     


Gly Val Ile Leu Thr Ile Tyr Gly Met Glu Arg Gly Asp Leu Thr Cys 
            580                 585                 590         


Leu Glu Glu Arg Cys Pro Phe Arg Glu Pro Gln Ser Ile Leu Arg Ala 
        595                 600                 605             


Leu Asp Val Glu Asp Ala Lys Leu Tyr Met Asp Phe Leu Val Leu Gly 
    610                 615                 620                 


Ile Phe Phe Leu Ala Leu Arg Leu Leu Ala Tyr Leu Val Leu Arg Tyr 
625                 630                 635                 640 


Arg Val Lys Ser Glu Arg 
                645     


<210>  71
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCG5__Homo_sapiens__NP_071881

<400>  71

Met Gly Asp Leu Ser Ser Leu Thr Pro Gly Gly Ser Met Gly Leu Gln 
1               5                   10                  15      


Val Asn Arg Gly Ser Gln Ser Ser Leu Glu Gly Ala Pro Ala Thr Ala 
            20                  25                  30          


Pro Glu Pro His Ser Leu Gly Ile Leu His Ala Ser Tyr Ser Val Ser 
        35                  40                  45              


His Arg Val Arg Pro Trp Trp Asp Ile Thr Ser Cys Arg Gln Gln Trp 
    50                  55                  60                  


Thr Arg Gln Ile Leu Lys Asp Val Ser Leu Tyr Val Glu Ser Gly Gln 
65                  70                  75                  80  


Ile Met Cys Ile Leu Gly Ser Ser Gly Ser Gly Lys Thr Thr Leu Leu 
                85                  90                  95      


Asp Ala Met Ser Gly Arg Leu Gly Arg Ala Gly Thr Phe Leu Gly Glu 
            100                 105                 110         


Val Tyr Val Asn Gly Arg Ala Leu Arg Arg Glu Gln Phe Gln Asp Cys 
        115                 120                 125             


Phe Ser Tyr Val Leu Gln Ser Asp Thr Leu Leu Ser Ser Leu Thr Val 
    130                 135                 140                 


Arg Glu Thr Leu His Tyr Thr Ala Leu Leu Ala Ile Arg Arg Gly Asn 
145                 150                 155                 160 


Pro Gly Ser Phe Gln Lys Lys Val Glu Ala Val Met Ala Glu Leu Ser 
                165                 170                 175     


Leu Ser His Val Ala Asp Arg Leu Ile Gly Asn Tyr Ser Leu Gly Gly 
            180                 185                 190         


Ile Ser Thr Gly Glu Arg Arg Arg Val Ser Ile Ala Ala Gln Leu Leu 
        195                 200                 205             


Gln Asp Pro Lys Val Met Leu Phe Asp Glu Pro Thr Thr Gly Leu Asp 
    210                 215                 220                 


Cys Met Thr Ala Asn Gln Ile Val Val Leu Leu Val Glu Leu Ala Arg 
225                 230                 235                 240 


Arg Asn Arg Ile Val Val Leu Thr Ile His Gln Pro Arg Ser Glu Leu 
                245                 250                 255     


Phe Gln Leu Phe Asp Lys Ile Ala Ile Leu Ser Phe Gly Glu Leu Ile 
            260                 265                 270         


Phe Cys Gly Thr Pro Ala Glu Met Leu Asp Phe Phe Asn Asp Cys Gly 
        275                 280                 285             


Tyr Pro Cys Pro Glu His Ser Asn Pro Phe Asp Phe Tyr Met Asp Leu 
    290                 295                 300                 


Thr Ser Val Asp Thr Gln Ser Lys Glu Arg Glu Ile Glu Thr Ser Lys 
305                 310                 315                 320 


Arg Val Gln Met Ile Glu Ser Ala Tyr Lys Lys Ser Ala Ile Cys His 
                325                 330                 335     


Lys Thr Leu Lys Asn Ile Glu Arg Met Lys His Leu Lys Thr Leu Pro 
            340                 345                 350         


Met Val Pro Phe Lys Thr Lys Asp Ser Pro Gly Val Phe Ser Lys Leu 
        355                 360                 365             


Gly Val Leu Leu Arg Arg Val Thr Arg Asn Leu Val Arg Asn Lys Leu 
    370                 375                 380                 


Ala Val Ile Thr Arg Leu Leu Gln Asn Leu Ile Met Gly Leu Phe Leu 
385                 390                 395                 400 


Leu Phe Phe Val Leu Arg Val Arg Ser Asn Val Leu Lys Gly Ala Ile 
                405                 410                 415     


Gln Asp Arg Val Gly Leu Leu Tyr Gln Phe Val Gly Ala Thr Pro Tyr 
            420                 425                 430         


Thr Gly Met Leu Asn Ala Val Asn Leu Phe Pro Val Leu Arg Ala Val 
        435                 440                 445             


Ser Asp Gln Glu Ser Gln Asp Gly Leu Tyr Gln Lys Trp Gln Met Met 
    450                 455                 460                 


Leu Ala Tyr Ala Leu His Val Leu Pro Phe Ser Val Val Ala Thr Met 
465                 470                 475                 480 


Ile Phe Ser Ser Val Cys Tyr Trp Thr Leu Gly Leu His Pro Glu Val 
                485                 490                 495     


Ala Arg Phe Gly Tyr Phe Ser Ala Ala Leu Leu Ala Pro His Leu Ile 
            500                 505                 510         


Gly Glu Phe Leu Thr Leu Val Leu Leu Gly Ile Val Gln Asn Pro Asn 
        515                 520                 525             


Ile Val Asn Ser Val Val Ala Leu Leu Ser Ile Ala Gly Val Leu Val 
    530                 535                 540                 


Gly Ser Gly Phe Leu Arg Asn Ile Gln Glu Met Pro Ile Pro Phe Lys 
545                 550                 555                 560 


Ile Ile Ser Tyr Phe Thr Phe Gln Lys Tyr Cys Ser Glu Ile Leu Val 
                565                 570                 575     


Val Asn Glu Phe Tyr Gly Leu Asn Phe Thr Cys Gly Ser Ser Asn Val 
            580                 585                 590         


Ser Val Thr Thr Asn Pro Met Cys Ala Phe Thr Gln Gly Ile Gln Phe 
        595                 600                 605             


Ile Glu Lys Thr Cys Pro Gly Ala Thr Ser Arg Phe Thr Met Asn Phe 
    610                 615                 620                 


Leu Ile Leu Tyr Ser Phe Ile Pro Ala Leu Val Ile Leu Gly Ile Val 
625                 630                 635                 640 


Val Phe Lys Ile Arg Asp His Leu Ile Ser Arg 
                645                 650     


<210>  72
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABCG8__Homo_sapiens__NP_071882

<400>  72

Met Ala Gly Lys Ala Ala Glu Glu Arg Gly Leu Pro Lys Gly Ala Thr 
1               5                   10                  15      


Pro Gln Asp Thr Ser Gly Leu Gln Asp Arg Leu Phe Ser Ser Glu Ser 
            20                  25                  30          


Asp Asn Ser Leu Tyr Phe Thr Tyr Ser Gly Gln Pro Asn Thr Leu Glu 
        35                  40                  45              


Val Arg Asp Leu Asn Tyr Gln Val Asp Leu Ala Ser Gln Val Pro Trp 
    50                  55                  60                  


Phe Glu Gln Leu Ala Gln Phe Lys Met Pro Trp Thr Ser Pro Ser Cys 
65                  70                  75                  80  


Gln Asn Ser Cys Glu Leu Gly Ile Gln Asn Leu Ser Phe Lys Val Arg 
                85                  90                  95      


Ser Gly Gln Met Leu Ala Ile Ile Gly Ser Ser Gly Cys Gly Arg Ala 
            100                 105                 110         


Ser Leu Leu Asp Val Ile Thr Gly Arg Gly His Gly Gly Lys Ile Lys 
        115                 120                 125             


Ser Gly Gln Ile Trp Ile Asn Gly Gln Pro Ser Ser Pro Gln Leu Val 
    130                 135                 140                 


Arg Lys Cys Val Ala His Val Arg Gln His Asn Gln Leu Leu Pro Asn 
145                 150                 155                 160 


Leu Thr Val Arg Glu Thr Leu Ala Phe Ile Ala Gln Met Arg Leu Pro 
                165                 170                 175     


Arg Thr Phe Ser Gln Ala Gln Arg Asp Lys Arg Val Glu Asp Val Ile 
            180                 185                 190         


Ala Glu Leu Arg Leu Arg Gln Cys Ala Asp Thr Arg Val Gly Asn Met 
        195                 200                 205             


Tyr Val Arg Gly Leu Ser Gly Gly Glu Arg Arg Arg Val Ser Ile Gly 
    210                 215                 220                 


Val Gln Leu Leu Trp Asn Pro Gly Ile Leu Ile Leu Asp Glu Pro Thr 
225                 230                 235                 240 


Ser Gly Leu Asp Ser Phe Thr Ala His Asn Leu Val Lys Thr Leu Ser 
                245                 250                 255     


Arg Leu Ala Lys Gly Asn Arg Leu Val Leu Ile Ser Leu His Gln Pro 
            260                 265                 270         


Arg Ser Asp Ile Phe Arg Leu Phe Asp Leu Val Leu Leu Met Thr Ser 
        275                 280                 285             


Gly Thr Pro Ile Tyr Leu Gly Ala Ala Gln His Met Val Gln Tyr Phe 
    290                 295                 300                 


Thr Ala Ile Gly Tyr Pro Cys Pro Arg Tyr Ser Asn Pro Ala Asp Phe 
305                 310                 315                 320 


Tyr Val Asp Leu Thr Ser Ile Asp Arg Arg Ser Arg Glu Gln Glu Leu 
                325                 330                 335     


Ala Thr Arg Glu Lys Ala Gln Ser Leu Ala Ala Leu Phe Leu Glu Lys 
            340                 345                 350         


Val Arg Asp Leu Asp Asp Phe Leu Trp Lys Ala Glu Thr Lys Asp Leu 
        355                 360                 365             


Asp Glu Asp Thr Cys Val Glu Ser Ser Val Thr Pro Leu Asp Thr Asn 
    370                 375                 380                 


Cys Leu Pro Ser Pro Thr Lys Met Pro Gly Ala Val Gln Gln Phe Thr 
385                 390                 395                 400 


Thr Leu Ile Arg Arg Gln Ile Ser Asn Asp Phe Arg Asp Leu Pro Thr 
                405                 410                 415     


Leu Leu Ile His Gly Ala Glu Ala Cys Leu Met Ser Met Thr Ile Gly 
            420                 425                 430         


Phe Leu Tyr Phe Gly His Gly Ser Ile Gln Leu Ser Phe Met Asp Thr 
        435                 440                 445             


Ala Ala Leu Leu Phe Met Ile Gly Ala Leu Ile Pro Phe Asn Val Ile 
    450                 455                 460                 


Leu Asp Val Ile Ser Lys Cys Tyr Ser Glu Arg Ala Met Leu Tyr Tyr 
465                 470                 475                 480 


Glu Leu Glu Asp Gly Leu Tyr Thr Thr Gly Pro Tyr Phe Phe Ala Lys 
                485                 490                 495     


Ile Leu Gly Glu Leu Pro Glu His Cys Ala Tyr Ile Ile Ile Tyr Gly 
            500                 505                 510         


Met Pro Thr Tyr Trp Leu Ala Asn Leu Arg Pro Gly Leu Gln Pro Phe 
        515                 520                 525             


Leu Leu His Phe Leu Leu Val Trp Leu Val Val Phe Cys Cys Arg Ile 
    530                 535                 540                 


Met Ala Leu Ala Ala Ala Ala Leu Leu Pro Thr Phe His Met Ala Ser 
545                 550                 555                 560 


Phe Phe Ser Asn Ala Leu Tyr Asn Ser Phe Tyr Leu Ala Gly Gly Phe 
                565                 570                 575     


Met Ile Asn Leu Ser Ser Leu Trp Thr Val Pro Ala Trp Ile Ser Lys 
            580                 585                 590         


Val Ser Phe Leu Arg Trp Cys Phe Glu Gly Leu Met Lys Ile Gln Phe 
        595                 600                 605             


Ser Arg Arg Thr Tyr Lys Met Pro Leu Gly Asn Leu Thr Ile Ala Val 
    610                 615                 620                 


Ser Gly Asp Lys Ile Leu Ser Val Met Glu Leu Asp Ser Tyr Pro Leu 
625                 630                 635                 640 


Tyr Ala Ile Tyr Leu Ile Val Ile Gly Leu Ser Gly Gly Phe Met Val 
                645                 650                 655     


Leu Tyr Tyr Val Ser Leu Arg Phe Ile Lys Gln Lys Pro Ser Gln Asp 
            660                 665                 670         


Trp 
    


<210>  73
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABHD12B__Homo_sapiens__NP_001193602

<400>  73

Met Asp Ala Gln Asp Cys Gln Ala Ala Ala Ser Pro Glu Pro Pro Gly 
1               5                   10                  15      


Pro Pro Ala Arg Ser Cys Val Ala Ala Trp Trp Asp Met Val Asp Arg 
            20                  25                  30          


Asn Leu Arg Tyr Phe Pro His Ser Cys Ser Met Leu Gly Arg Lys Ile 
        35                  40                  45              


Ala Ala Leu Tyr Asp Ser Phe Thr Ser Lys Ser Leu Lys Glu His Val 
    50                  55                  60                  


Phe Leu Pro Leu Ile Asp Met Leu Ile Tyr Phe Asn Phe Phe Lys Ala 
65                  70                  75                  80  


Pro Phe Leu Val Asp Leu Lys Lys Pro Glu Leu Lys Ile Pro His Thr 
                85                  90                  95      


Val Asn Phe Tyr Leu Arg Val Glu Pro Gly Val Met Leu Gly Ile Trp 
            100                 105                 110         


His Thr Val Pro Ser Cys Arg Gly Glu Asp Ala Lys Gly Lys Asp Cys 
        115                 120                 125             


Cys Trp Tyr Glu Ala Ala Leu Arg Asp Gly Asn Pro Ile Ile Val Tyr 
    130                 135                 140                 


Leu His Gly Ser Ala Glu His Arg Ala Ala Ser His Arg Leu Lys Leu 
145                 150                 155                 160 


Val Lys Val Leu Ser Asp Gly Gly Phe His Val Leu Ser Val Asp Tyr 
                165                 170                 175     


Arg Gly Phe Gly Asp Ser Thr Gly Lys Pro Thr Glu Glu Gly Leu Thr 
            180                 185                 190         


Thr Asp Ala Ile Cys Val Tyr Glu Trp Thr Lys Ala Arg Ser Gly Ile 
        195                 200                 205             


Thr Pro Val Cys Leu Trp Gly His Ser Leu Gly Thr Gly Val Ala Thr 
    210                 215                 220                 


Asn Ala Ala Lys Val Leu Glu Glu Lys Gly Cys Pro Val Asp Ala Ile 
225                 230                 235                 240 


Val Leu Glu Ala Pro Phe Thr Asn Met Trp Val Ala Ser Ile Asn Tyr 
                245                 250                 255     


Pro Leu Leu Lys Ile Tyr Arg Asn Ile Pro Gly Phe Leu Arg Thr Leu 
            260                 265                 270         


Met Asp Ala Leu Arg Lys Asp Lys Ile Ile Phe Pro Asn Asp Glu Asn 
        275                 280                 285             


Val Lys Phe Leu Ser Ser Pro Leu Leu Ile Leu His Gly Glu Asp Asp 
    290                 295                 300                 


Arg Thr Val Pro Leu Glu Tyr Gly Lys Lys Leu Tyr Glu Ile Ala Arg 
305                 310                 315                 320 


Asn Ala Tyr Arg Asn Lys Glu Arg Val Lys Met Val Ile Phe Pro Pro 
                325                 330                 335     


Gly Phe Gln His Asn Leu Leu Cys Lys Ser Pro Thr Leu Leu Ile Thr 
            340                 345                 350         


Val Arg Asp Phe Leu Ser Lys Gln Trp Ser 
        355                 360         


<210>  74
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABHD12__Homo_sapiens__NP_001035937

<400>  74

Met Arg Lys Arg Thr Glu Pro Val Ala Leu Glu His Glu Arg Cys Ala 
1               5                   10                  15      


Ala Ala Gly Ser Ser Ser Ser Gly Ser Ala Ala Ala Ala Leu Asp Ala 
            20                  25                  30          


Asp Cys Arg Leu Lys Gln Asn Leu Arg Leu Thr Gly Pro Ala Ala Ala 
        35                  40                  45              


Glu Pro Arg Cys Ala Ala Asp Ala Gly Met Lys Arg Ala Leu Gly Arg 
    50                  55                  60                  


Arg Lys Gly Val Trp Leu Arg Leu Arg Lys Ile Leu Phe Cys Val Leu 
65                  70                  75                  80  


Gly Leu Tyr Ile Ala Ile Pro Phe Leu Ile Lys Leu Cys Pro Gly Ile 
                85                  90                  95      


Gln Ala Lys Leu Ile Phe Leu Asn Phe Val Arg Val Pro Tyr Phe Ile 
            100                 105                 110         


Asp Leu Lys Lys Pro Gln Asp Gln Gly Leu Asn His Thr Cys Asn Tyr 
        115                 120                 125             


Tyr Leu Gln Pro Glu Glu Asp Val Thr Ile Gly Val Trp His Thr Val 
    130                 135                 140                 


Pro Ala Val Trp Trp Lys Asn Ala Gln Gly Lys Asp Gln Met Trp Tyr 
145                 150                 155                 160 


Glu Asp Ala Leu Ala Ser Ser His Pro Ile Ile Leu Tyr Leu His Gly 
                165                 170                 175     


Asn Ala Gly Thr Arg Gly Gly Asp His Arg Val Glu Leu Tyr Lys Val 
            180                 185                 190         


Leu Ser Ser Leu Gly Tyr His Val Val Thr Phe Asp Tyr Arg Gly Trp 
        195                 200                 205             


Gly Asp Ser Val Gly Thr Pro Ser Glu Arg Gly Met Thr Tyr Asp Ala 
    210                 215                 220                 


Leu His Val Phe Asp Trp Ile Lys Ala Arg Ser Gly Asp Asn Pro Val 
225                 230                 235                 240 


Tyr Ile Trp Gly His Ser Leu Gly Thr Gly Val Ala Thr Asn Leu Val 
                245                 250                 255     


Arg Arg Leu Cys Glu Arg Glu Thr Pro Pro Asp Ala Leu Ile Leu Glu 
            260                 265                 270         


Ser Pro Phe Thr Asn Ile Arg Glu Glu Ala Lys Ser His Pro Phe Ser 
        275                 280                 285             


Val Ile Tyr Arg Tyr Phe Pro Gly Phe Asp Trp Phe Phe Leu Asp Pro 
    290                 295                 300                 


Ile Thr Ser Ser Gly Ile Lys Phe Ala Asn Asp Glu Asn Val Lys His 
305                 310                 315                 320 


Ile Ser Cys Pro Leu Leu Ile Leu His Ala Glu Asp Asp Pro Val Val 
                325                 330                 335     


Pro Phe Gln Leu Gly Arg Lys Leu Tyr Ser Ile Ala Ala Pro Ala Arg 
            340                 345                 350         


Ser Phe Arg Asp Phe Lys Val Gln Phe Val Pro Phe His Ser Asp Leu 
        355                 360                 365             


Gly Tyr Arg His Lys Tyr Ile Tyr Lys Ser Pro Glu Leu Pro Arg Ile 
    370                 375                 380                 


Leu Arg Glu Phe Leu Gly Lys Ser Glu Pro Glu His Gln His 
385                 390                 395             


<210>  75
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABHD16A__Homo_sapiens__NP_001170986

<400>  75

Met Pro Pro Pro Ala Leu Phe Leu Ser Ser Leu Tyr Pro Arg Leu Glu 
1               5                   10                  15      


Phe Gln Asn Asp Phe Tyr Arg Ser Cys Ile Arg Arg Ser Ser Pro Gln 
            20                  25                  30          


Pro Pro Pro Asn Leu Ala Trp Arg Pro Glu Ser Leu Tyr Ser Gly Glu 
        35                  40                  45              


Leu Ala Gly Gly Gly Tyr Leu Ser Leu Ser Lys Val Val Pro Phe Ser 
    50                  55                  60                  


His Tyr Ala Gly Thr Leu Leu Leu Leu Leu Ala Gly Val Ala Cys Leu 
65                  70                  75                  80  


Arg Gly Ile Gly Arg Trp Thr Asn Pro Gln Tyr Arg Gln Phe Ile Thr 
                85                  90                  95      


Ile Leu Glu Ala Thr His Arg Asn Gln Ser Ser Glu Asn Lys Arg Gln 
            100                 105                 110         


Leu Ala Asn Tyr Asn Phe Asp Phe Arg Ser Trp Pro Val Asp Phe His 
        115                 120                 125             


Trp Glu Glu Pro Ser Ser Arg Lys Glu Ser Arg Gly Gly Pro Ser Arg 
    130                 135                 140                 


Arg Gly Val Ala Leu Leu Arg Pro Glu Pro Leu His Arg Gly Thr Ala 
145                 150                 155                 160 


Asp Thr Leu Leu Asn Arg Val Lys Lys Leu Pro Cys Gln Ile Thr Ser 
                165                 170                 175     


Tyr Leu Val Ala His Thr Leu Gly Arg Arg Met Leu Tyr Pro Gly Ser 
            180                 185                 190         


Val Tyr Leu Leu Gln Lys Ala Leu Met Pro Val Leu Leu Gln Gly Gln 
        195                 200                 205             


Ala Arg Leu Val Glu Glu Cys Asn Gly Arg Arg Ala Lys Leu Leu Ala 
    210                 215                 220                 


Cys Asp Gly Asn Glu Ile Asp Thr Met Phe Val Asp Arg Arg Gly Thr 
225                 230                 235                 240 


Ala Glu Pro Gln Gly Gln Lys Leu Val Ile Cys Cys Glu Gly Asn Ala 
                245                 250                 255     


Gly Phe Tyr Glu Val Gly Cys Val Ser Thr Pro Leu Glu Ala Gly Tyr 
            260                 265                 270         


Ser Val Leu Gly Trp Asn His Pro Gly Phe Ala Gly Ser Thr Gly Val 
        275                 280                 285             


Pro Phe Pro Gln Asn Glu Ala Asn Ala Met Asp Val Val Val Gln Phe 
    290                 295                 300                 


Ala Ile His Arg Leu Gly Phe Gln Pro Gln Asp Ile Ile Ile Tyr Ala 
305                 310                 315                 320 


Trp Ser Ile Gly Gly Phe Thr Ala Thr Trp Ala Ala Met Ser Tyr Pro 
                325                 330                 335     


Asp Val Ser Ala Met Ile Leu Asp Ala Ser Phe Asp Asp Leu Val Pro 
            340                 345                 350         


Leu Ala Leu Lys Val Met Pro Asp Ser Trp Arg Gly Leu Val Thr Arg 
        355                 360                 365             


Thr Val Arg Gln His Leu Asn Leu Asn Asn Ala Glu Gln Leu Cys Arg 
    370                 375                 380                 


Tyr Gln Gly Pro Val Leu Leu Ile Arg Arg Thr Lys Asp Glu Ile Ile 
385                 390                 395                 400 


Thr Thr Thr Val Pro Glu Asp Ile Met Ser Asn Arg Gly Asn Asp Leu 
                405                 410                 415     


Leu Leu Lys Leu Leu Gln His Arg Tyr Pro Arg Val Met Ala Glu Glu 
            420                 425                 430         


Gly Leu Arg Val Val Arg Gln Trp Leu Glu Ala Ser Ser Gln Leu Glu 
        435                 440                 445             


Glu Ala Ser Ile Tyr Ser Arg Trp Glu Val Glu Glu Asp Trp Cys Leu 
    450                 455                 460                 


Ser Val Leu Arg Ser Tyr Gln Ala Glu His Gly Pro Asp Phe Pro Trp 
465                 470                 475                 480 


Ser Val Gly Glu Asp Met Ser Ala Asp Gly Arg Arg Gln Leu Ala Leu 
                485                 490                 495     


Phe Leu Ala Arg Lys His Leu His Asn Phe Glu Ala Thr His Cys Thr 
            500                 505                 510         


Pro Leu Pro Ala Gln Asn Phe Gln Met Pro Trp His Leu 
        515                 520                 525 


<210>  76
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABHD17B__Homo_sapiens__NP_001020951

<400>  76

Met Asn Asn Leu Ser Phe Ser Glu Leu Cys Cys Leu Phe Cys Cys Pro 
1               5                   10                  15      


Pro Cys Pro Gly Lys Ile Ala Ser Lys Leu Ala Phe Leu Pro Pro Asp 
            20                  25                  30          


Pro Thr Tyr Thr Leu Met Cys Asp Glu Ser Gly Ser Arg Trp Thr Leu 
        35                  40                  45              


His Leu Ser Glu Arg Ala Asp Trp Gln Tyr Ser Ser Arg Glu Lys Asp 
    50                  55                  60                  


Ala Ile Glu Cys Phe Met Thr Arg Thr Ser Lys Gly Asn Arg Ile Ala 
65                  70                  75                  80  


Cys Met Phe Val Arg Cys Ser Pro Asn Ala Lys Tyr Thr Leu Leu Phe 
                85                  90                  95      


Ser His Gly Asn Ala Val Asp Leu Gly Gln Met Ser Ser Phe Tyr Ile 
            100                 105                 110         


Gly Leu Gly Ser Arg Ile Asn Cys Asn Ile Phe Ser Tyr Asp Tyr Ser 
        115                 120                 125             


Gly Tyr Gly Ala Ser Ser Gly Lys Pro Thr Glu Lys Asn Leu Tyr Ala 
    130                 135                 140                 


Asp Ile Glu Ala Ala Trp Leu Ala Leu Arg Thr Arg Tyr Gly Ile Arg 
145                 150                 155                 160 


Pro Glu Asn Val Ile Ile Tyr Gly Gln Ser Ile Gly Thr Val Pro Ser 
                165                 170                 175     


Val Asp Leu Ala Ala Arg Tyr Glu Ser Ala Ala Val Ile Leu His Ser 
            180                 185                 190         


Pro Leu Thr Ser Gly Met Arg Val Ala Phe Pro Asp Thr Lys Lys Thr 
        195                 200                 205             


Tyr Cys Phe Asp Ala Phe Pro Asn Ile Asp Lys Ile Ser Lys Ile Thr 
    210                 215                 220                 


Ser Pro Val Leu Ile Ile His Gly Thr Glu Asp Glu Val Ile Asp Phe 
225                 230                 235                 240 


Ser His Gly Leu Ala Leu Phe Glu Arg Cys Gln Arg Pro Val Glu Pro 
                245                 250                 255     


Leu Trp Val Glu Gly Ala Gly His Asn Asp Val Glu Leu Tyr Gly Gln 
            260                 265                 270         


Tyr Leu Glu Arg Leu Lys Gln Phe Val Ser Gln Glu Leu Val Asn Leu 
        275                 280                 285             


<210>  77
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABHD2__Homo_sapiens__XP_005254890

<400>  77

Met Asn Ala Met Leu Glu Thr Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15      


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30          


Leu Asn Leu Lys Ser Pro Thr Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45              


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Thr Lys 
    50                  55                  60                  


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Thr 
65                  70                  75                  80  


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95      


His Arg Lys Phe Ile Thr Met Ser Asp Gly Ala Thr Ser Thr Phe Asp 
            100                 105                 110         


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly Asp Asp Ile Thr Met 
        115                 120                 125             


Val Ile Cys Pro Gly Ile Ala Asn His Ser Glu Lys Gln Tyr Ile Arg 
    130                 135                 140                 


Thr Phe Val Asp Tyr Ala Gln Lys Asn Gly Tyr Arg Cys Ala Val Leu 
145                 150                 155                 160 


Asn His Leu Gly Ala Leu Pro Asn Ile Glu Leu Thr Ser Pro Arg Met 
                165                 170                 175     


Phe Thr Tyr Gly Cys Thr Trp Glu Phe Gly Ala Met Val Asn Tyr Ile 
            180                 185                 190         


Lys Lys Thr Tyr Pro Leu Thr Gln Leu Val Val Val Gly Phe Ser Leu 
        195                 200                 205             


Gly Gly Asn Ile Val Cys Lys Tyr Leu Gly Glu Thr Gln Ala Asn Gln 
    210                 215                 220                 


Glu Lys Val Leu Cys Cys Val Ser Val Cys Gln Gly Tyr Ser Ala Leu 
225                 230                 235                 240 


Arg Ala Gln Glu Thr Phe Met Gln Trp Asp Gln Cys Arg Arg Phe Tyr 
                245                 250                 255     


Asn Phe Leu Met Ala Asp Asn Met Lys Lys Ile Ile Leu Ser His Arg 
            260                 265                 270         


Gln Ala Leu Phe Gly Asp His Val Lys Lys Pro Gln Ser Leu Glu Asp 
        275                 280                 285             


Thr Asp Leu Ser Arg Leu Tyr Thr Ala Thr Ser Leu Met Gln Ile Asp 
    290                 295                 300                 


Asp Asn Val Met Arg Lys Phe His Gly Tyr Asn Ser Leu Lys Glu Tyr 
305                 310                 315                 320 


Tyr Glu Glu Glu Ser Cys Met Arg Tyr Leu His Arg Ile Tyr Val Pro 
                325                 330                 335     


Leu Met Leu Val Asn Ala Ala Asp Asp Pro Leu Val His Glu Ser Leu 
            340                 345                 350         


Leu Thr Ile Pro Lys Ser Leu Ser Glu Lys Arg Glu Asn Val Met Phe 
        355                 360                 365             


Val Leu Pro Leu His Gly Gly His Leu Gly Phe Phe Glu Gly Ser Val 
    370                 375                 380                 


Leu Phe Pro Glu Pro Leu Thr Trp Met Asp Lys Leu Val Val Glu Tyr 
385                 390                 395                 400 


Ala Asn Ala Ile Cys Gln Trp Glu Arg Asn Lys Leu Gln Cys Ser Asp 
                405                 410                 415     


Thr Glu Gln Val Glu Ala Asp Leu Glu 
            420                 425 


<210>  78
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABHD5__Homo_sapiens__NP_057090

<400>  78

Met Ala Ala Glu Glu Glu Glu Val Asp Ser Ala Asp Thr Gly Glu Arg 
1               5                   10                  15      


Ser Gly Trp Leu Thr Gly Trp Leu Pro Thr Trp Cys Pro Thr Ser Ile 
            20                  25                  30          


Ser His Leu Lys Glu Ala Glu Glu Lys Met Leu Lys Cys Val Pro Cys 
        35                  40                  45              


Thr Tyr Lys Lys Glu Pro Val Arg Ile Ser Asn Gly Asn Lys Ile Trp 
    50                  55                  60                  


Thr Leu Lys Phe Ser His Asn Ile Ser Asn Lys Thr Pro Leu Val Leu 
65                  70                  75                  80  


Leu His Gly Phe Gly Gly Gly Leu Gly Leu Trp Ala Leu Asn Phe Gly 
                85                  90                  95      


Asp Leu Cys Thr Asn Arg Pro Val Tyr Ala Phe Asp Leu Leu Gly Phe 
            100                 105                 110         


Gly Arg Ser Ser Arg Pro Arg Phe Asp Ser Asp Ala Glu Glu Val Glu 
        115                 120                 125             


Asn Gln Phe Val Glu Ser Ile Glu Glu Trp Arg Cys Ala Leu Gly Leu 
    130                 135                 140                 


Asp Lys Met Ile Leu Leu Gly His Asn Leu Gly Gly Phe Leu Ala Ala 
145                 150                 155                 160 


Ala Tyr Ser Leu Lys Tyr Pro Ser Arg Val Asn His Leu Ile Leu Val 
                165                 170                 175     


Glu Pro Trp Gly Phe Pro Glu Arg Pro Asp Leu Ala Asp Gln Asp Arg 
            180                 185                 190         


Pro Ile Pro Val Trp Ile Arg Ala Leu Gly Ala Ala Leu Thr Pro Phe 
        195                 200                 205             


Asn Pro Leu Ala Gly Leu Arg Ile Ala Gly Pro Phe Gly Leu Ser Leu 
    210                 215                 220                 


Val Gln Arg Leu Arg Pro Asp Phe Lys Arg Lys Tyr Ser Ser Met Phe 
225                 230                 235                 240 


Glu Asp Asp Thr Val Thr Glu Tyr Ile Tyr His Cys Asn Val Gln Thr 
                245                 250                 255     


Pro Ser Gly Glu Thr Ala Phe Lys Asn Met Thr Ile Pro Tyr Gly Trp 
            260                 265                 270         


Ala Lys Arg Pro Met Leu Gln Arg Ile Gly Lys Met His Pro Asp Ile 
        275                 280                 285             


Pro Val Ser Val Ile Phe Gly Ala Arg Ser Cys Ile Asp Gly Asn Ser 
    290                 295                 300                 


Gly Thr Ser Ile Gln Ser Leu Arg Pro His Ser Tyr Val Lys Thr Ile 
305                 310                 315                 320 


Ala Ile Leu Gly Ala Gly His Tyr Val Tyr Ala Asp Gln Pro Glu Glu 
                325                 330                 335     


Phe Asn Gln Lys Val Lys Glu Ile Cys Asp Thr Val Asp 
            340                 345                 


<210>  79
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABHD6__Homo_sapiens__NP_065727

<400>  79

Met Asp Leu Asp Val Val Asn Met Phe Val Ile Ala Gly Gly Thr Leu 
1               5                   10                  15      


Ala Ile Pro Ile Leu Ala Phe Val Ala Ser Phe Leu Leu Trp Pro Ser 
            20                  25                  30          


Ala Leu Ile Arg Ile Tyr Tyr Trp Tyr Trp Arg Arg Thr Leu Gly Met 
        35                  40                  45              


Gln Val Arg Tyr Val His His Glu Asp Tyr Gln Phe Cys Tyr Ser Phe 
    50                  55                  60                  


Arg Gly Arg Pro Gly His Lys Pro Ser Ile Leu Met Leu His Gly Phe 
65                  70                  75                  80  


Ser Ala His Lys Asp Met Trp Leu Ser Val Val Lys Phe Leu Pro Lys 
                85                  90                  95      


Asn Leu His Leu Val Cys Val Asp Met Pro Gly His Glu Gly Thr Thr 
            100                 105                 110         


Arg Ser Ser Leu Asp Asp Leu Ser Ile Asp Gly Gln Val Lys Arg Ile 
        115                 120                 125             


His Gln Phe Val Glu Cys Leu Lys Leu Asn Lys Lys Pro Phe His Leu 
    130                 135                 140                 


Val Gly Thr Ser Met Gly Gly Gln Val Ala Gly Val Tyr Ala Ala Tyr 
145                 150                 155                 160 


Tyr Pro Ser Asp Val Ser Ser Leu Cys Leu Val Cys Pro Ala Gly Leu 
                165                 170                 175     


Gln Tyr Ser Thr Asp Asn Gln Phe Val Gln Arg Leu Lys Glu Leu Gln 
            180                 185                 190         


Gly Ser Ala Ala Val Glu Lys Ile Pro Leu Ile Pro Ser Thr Pro Glu 
        195                 200                 205             


Glu Met Ser Glu Met Leu Gln Leu Cys Ser Tyr Val Arg Phe Lys Val 
    210                 215                 220                 


Pro Gln Gln Ile Leu Gln Gly Leu Val Asp Val Arg Ile Pro His Asn 
225                 230                 235                 240 


Asn Phe Tyr Arg Lys Leu Phe Leu Glu Ile Val Ser Glu Lys Ser Arg 
                245                 250                 255     


Tyr Ser Leu His Gln Asn Met Asp Lys Ile Lys Val Pro Thr Gln Ile 
            260                 265                 270         


Ile Trp Gly Lys Gln Asp Gln Val Leu Asp Val Ser Gly Ala Asp Met 
        275                 280                 285             


Leu Ala Lys Ser Ile Ala Asn Cys Gln Val Glu Leu Leu Glu Asn Cys 
    290                 295                 300                 


Gly His Ser Val Val Met Glu Arg Pro Arg Lys Thr Ala Lys Leu Ile 
305                 310                 315                 320 


Ile Asp Phe Leu Ala Ser Val His Asn Thr Asp Asn Asn Lys Lys Leu 
                325                 330                 335     


Asp 
    


<210>  80
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABI1__Homo_sapiens__NP_001012768

<400>  80

Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Ser Gly Lys 
1               5                   10                  15      


Arg Ala Leu Ile Glu Ser Tyr Gln Asn Leu Thr Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Ile Asn Ala Leu Ala Asn Asn Val Leu Gln Leu Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Met Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Val Leu Asp Asp Val Gly His Gly Val Lys Trp Leu Lys Ala Lys His 
145                 150                 155                 160 


Gly Asn Asn Gln Pro Ala Arg Thr Gly Thr Leu Ser Arg Thr Asn Pro 
                165                 170                 175     


Pro Thr Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Arg Gly Thr Leu 
            180                 185                 190         


Gly Arg Asn Thr Pro Tyr Lys Thr Leu Glu Pro Val Lys Pro Pro Thr 
        195                 200                 205             


Val Pro Asn Asp Tyr Met Thr Ser Pro Ala Arg Leu Gly Ser Gln His 
    210                 215                 220                 


Ser Pro Gly Arg Thr Ala Ser Leu Asn Gln Arg Pro Arg Thr His Ser 
225                 230                 235                 240 


Gly Ser Ser Gly Gly Ser Gly Ser Arg Glu Asn Ser Gly Ser Ser Ser 
                245                 250                 255     


Ile Gly Ile Pro Ile Ala Val Pro Thr Pro Ser Pro Pro Thr Ile Gly 
            260                 265                 270         


Pro Ala Ala Pro Gly Ser Ala Pro Gly Ser Gln Tyr Gly Thr Met Thr 
        275                 280                 285             


Arg Gln Ile Ser Arg His Asn Ser Thr Thr Ser Ser Thr Ser Ser Gly 
    290                 295                 300                 


Gly Tyr Arg Arg Thr Pro Ser Val Thr Ala Gln Phe Ser Ala Gln Pro 
305                 310                 315                 320 


His Val Asn Gly Gly Pro Leu Tyr Ser Gln Asn Ser Ile Ser Ile Ala 
                325                 330                 335     


Pro Pro Pro Pro Pro Met Pro Gln Leu Thr Pro Gln Ile Pro Leu Thr 
            340                 345                 350         


Gly Phe Val Ala Arg Val Gln Glu Asn Ile Ala Asp Ser Pro Thr Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Pro Asp Asp Ile Pro Met Phe Asp Asp Ser Pro 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Pro Val Asp Tyr Glu Asp Glu Glu Ala Ala 
385                 390                 395                 400 


Val Val Gln Tyr Asn Asp Pro Tyr Ala Asp Gly Asp Pro Ala Trp Ala 
                405                 410                 415     


Pro Lys Asn Tyr Ile Glu Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys 
            420                 425                 430         


Asp Lys Asp Asp Glu Leu Ser Phe Met Glu Gly Ala Ile Ile Tyr Val 
        435                 440                 445             


Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Cys Asn Arg Val 
    450                 455                 460                 


Thr Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Thr 
465                 470                 475                 480 


Asp 
    


<210>  81
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABI2__Homo_sapiens__NP_001269854

<400>  81

Met Ala Glu Leu Gln Met Leu Leu Glu Glu Glu Ile Pro Gly Gly Arg 
1               5                   10                  15      


Arg Ala Leu Phe Asp Ser Tyr Thr Asn Leu Glu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asn Asn Tyr Ile Gln Ser Ala Asp Lys Gln Arg Ala Leu Glu 
        35                  40                  45              


Glu Thr Lys Ala Tyr Thr Thr Gln Ser Leu Ala Ser Val Ala Tyr Leu 
    50                  55                  60                  


Ile Asn Thr Leu Ala Asn Asn Val Leu Gln Met Leu Asp Ile Gln Ala 
65                  70                  75                  80  


Ser Gln Leu Arg Arg Met Glu Ser Ser Ile Asn His Ile Ser Gln Thr 
                85                  90                  95      


Val Asp Ile His Lys Glu Lys Val Ala Arg Arg Glu Ile Gly Ile Leu 
            100                 105                 110         


Thr Thr Asn Lys Asn Thr Ser Arg Thr His Lys Ile Ile Ala Pro Ala 
        115                 120                 125             


Asn Leu Glu Arg Pro Val Arg Tyr Ile Arg Lys Pro Ile Asp Tyr Thr 
    130                 135                 140                 


Ile Leu Asp Asp Ile Gly His Gly Val Lys Trp Leu Leu Arg Phe Lys 
145                 150                 155                 160 


Val Ser Thr Gln Asn Met Lys Met Gly Gly Leu Pro Arg Thr Thr Pro 
                165                 170                 175     


Pro Thr Gln Lys Pro Pro Ser Pro Pro Met Ser Gly Lys Gly Thr Leu 
            180                 185                 190         


Gly Arg His Ser Pro Tyr Arg Thr Leu Glu Pro Val Arg Pro Pro Val 
        195                 200                 205             


Val Pro Asn Asp Tyr Val Pro Ser Pro Thr Arg Asn Met Ala Pro Ser 
    210                 215                 220                 


Gln Gln Ser Pro Val Arg Thr Ala Ser Val Asn Gln Arg Asn Arg Thr 
225                 230                 235                 240 


Tyr Ser Ser Ser Gly Ser Ser Gly Gly Ser His Pro Ser Ser Arg Ser 
                245                 250                 255     


Ser Ser Arg Glu Asn Ser Gly Ser Gly Ser Val Gly Val Pro Ile Ala 
            260                 265                 270         


Val Pro Thr Pro Ser Pro Pro Ser Val Phe Pro Ala Pro Ala Gly Ser 
        275                 280                 285             


Ala Gly Thr Pro Pro Leu Pro Ala Thr Ser Ala Ser Ala Pro Ala Pro 
    290                 295                 300                 


Leu Val Pro Ala Thr Val Pro Ser Ser Thr Ala Pro Asp Ala Ala Ala 
305                 310                 315                 320 


Gly Gly Ala Gln Thr Leu Ala Asp Gly Phe Thr Ser Pro Thr Pro Pro 
                325                 330                 335     


Val Val Ser Ser Thr Pro Pro Thr Gly His Pro Val Gln Phe Tyr Ser 
            340                 345                 350         


Met Asn Arg Pro Ala Ser Arg His Thr Pro Pro Thr Ile Gly Gly Ser 
        355                 360                 365             


Leu Pro Tyr Arg Arg Pro Pro Ser Ile Thr Ser Gln Thr Ser Leu Gln 
    370                 375                 380                 


Asn Gln Met Asn Gly Gly Pro Phe Tyr Ser Gln Asn Pro Val Ser Asp 
385                 390                 395                 400 


Thr Pro Pro Pro Pro Pro Pro Val Glu Glu Pro Val Phe Asp Glu Ser 
                405                 410                 415     


Pro Pro Pro Pro Pro Pro Pro Glu Asp Tyr Glu Glu Glu Glu Ala Ala 
            420                 425                 430         


Val Val Glu Tyr Ser Asp Pro Tyr Ala Glu Glu Asp Pro Pro Trp Ala 
        435                 440                 445             


Pro Arg Ser Tyr Leu Glu Lys Val Val Ala Ile Tyr Asp Tyr Thr Lys 
    450                 455                 460                 


Asp Lys Glu Asp Glu Leu Ser Phe Gln Glu Gly Ala Ile Ile Tyr Val 
465                 470                 475                 480 


Ile Lys Lys Asn Asp Asp Gly Trp Tyr Glu Gly Val Met Asn Gly Val 
                485                 490                 495     


Thr Gly Leu Phe Pro Gly Asn Tyr Val Glu Ser Ile Met His Tyr Ser 
            500                 505                 510         


Glu 
    


<210>  82
<211>  1075
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABI3BP__Homo_sapiens__NP_056244

<400>  82

Met Arg Gly Gly Lys Cys Asn Met Leu Ser Ser Leu Gly Cys Leu Leu 
1               5                   10                  15      


Leu Cys Gly Ser Ile Thr Leu Ala Leu Gly Asn Ala Gln Lys Leu Pro 
            20                  25                  30          


Lys Gly Lys Arg Pro Asn Leu Lys Val His Ile Asn Thr Thr Ser Asp 
        35                  40                  45              


Ser Ile Leu Leu Lys Phe Leu Arg Pro Ser Pro Asn Val Lys Leu Glu 
    50                  55                  60                  


Gly Leu Leu Leu Gly Tyr Gly Ser Asn Val Ser Pro Asn Gln Tyr Phe 
65                  70                  75                  80  


Pro Leu Pro Ala Glu Gly Lys Phe Thr Glu Ala Ile Val Asp Ala Glu 
                85                  90                  95      


Pro Lys Tyr Leu Ile Val Val Arg Pro Ala Pro Pro Pro Ser Gln Lys 
            100                 105                 110         


Lys Ser Cys Ser Gly Lys Thr Arg Ser Arg Lys Pro Leu Gln Leu Val 
        115                 120                 125             


Val Gly Thr Leu Thr Pro Ser Ser Val Phe Leu Ser Trp Gly Phe Leu 
    130                 135                 140                 


Ile Asn Pro His His Asp Trp Thr Leu Pro Ser His Cys Pro Asn Asp 
145                 150                 155                 160 


Arg Phe Tyr Thr Ile Arg Tyr Arg Glu Lys Asp Lys Glu Lys Lys Trp 
                165                 170                 175     


Ile Phe Gln Ile Cys Pro Ala Thr Glu Thr Ile Val Glu Asn Leu Lys 
            180                 185                 190         


Pro Asn Thr Val Tyr Glu Phe Gly Val Lys Asp Asn Val Glu Gly Gly 
        195                 200                 205             


Ile Trp Ser Lys Ile Phe Asn His Lys Thr Val Val Gly Ser Lys Lys 
    210                 215                 220                 


Val Asn Gly Lys Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro 
225                 230                 235                 240 


Ala Tyr Val Pro Arg Lys Leu Ile Pro Ile Thr Ile Ile Lys Gln Val 
                245                 250                 255     


Ile Gln Asn Val Thr His Lys Asp Ser Ala Lys Ser Pro Glu Lys Ala 
            260                 265                 270         


Pro Leu Gly Gly Val Ile Leu Val His Leu Ile Ile Pro Gly Leu Asn 
        275                 280                 285             


Glu Thr Thr Val Lys Leu Pro Ala Ser Leu Met Phe Glu Ile Ser Asp 
    290                 295                 300                 


Ala Leu Lys Thr Gln Leu Ala Lys Asn Glu Thr Leu Ala Leu Pro Ala 
305                 310                 315                 320 


Glu Ser Lys Thr Pro Glu Val Glu Lys Ile Ser Ala Arg Pro Thr Thr 
                325                 330                 335     


Val Thr Pro Glu Thr Val Pro Arg Ser Thr Lys Pro Thr Thr Ser Ser 
            340                 345                 350         


Ala Leu Asp Val Ser Glu Thr Thr Leu Ala Ser Ser Glu Lys Pro Trp 
        355                 360                 365             


Ile Val Pro Thr Ala Lys Ile Ser Glu Asp Ser Lys Val Leu Gln Pro 
    370                 375                 380                 


Gln Thr Ala Thr Tyr Asp Val Phe Ser Ser Pro Thr Thr Ser Asp Glu 
385                 390                 395                 400 


Pro Glu Ile Ser Asp Ser Tyr Thr Ala Thr Ser Asp Arg Ile Leu Asp 
                405                 410                 415     


Ser Ile Pro Pro Lys Thr Ser Arg Thr Leu Glu Gln Pro Arg Ala Thr 
            420                 425                 430         


Leu Ala Pro Ser Glu Thr Pro Phe Val Pro Gln Lys Leu Glu Ile Phe 
        435                 440                 445             


Thr Ser Pro Glu Met Gln Pro Thr Thr Pro Ala Pro Gln Gln Thr Thr 
    450                 455                 460                 


Ser Ile Pro Ser Thr Pro Lys Arg Arg Pro Arg Pro Lys Pro Pro Arg 
465                 470                 475                 480 


Thr Lys Pro Glu Arg Thr Thr Ser Ala Gly Thr Ile Thr Pro Lys Ile 
                485                 490                 495     


Ser Lys Ser Pro Glu Pro Thr Trp Thr Thr Pro Ala Pro Gly Lys Thr 
            500                 505                 510         


Gln Phe Ile Ser Leu Lys Pro Lys Ile Pro Leu Ser Pro Glu Val Thr 
        515                 520                 525             


His Thr Lys Pro Ala Pro Lys Gln Thr Pro Arg Ala Pro Pro Lys Pro 
    530                 535                 540                 


Lys Thr Ser Pro Arg Pro Arg Ile Pro Gln Thr Gln Pro Val Pro Lys 
545                 550                 555                 560 


Val Pro Gln Arg Val Thr Ala Lys Pro Lys Thr Ser Pro Ser Pro Glu 
                565                 570                 575     


Val Ser Tyr Thr Thr Pro Ala Pro Lys Asp Val Leu Leu Pro His Lys 
            580                 585                 590         


Pro Tyr Pro Glu Val Ser Gln Ser Glu Pro Ala Pro Leu Glu Thr Arg 
        595                 600                 605             


Gly Ile Pro Phe Ile Pro Met Ile Ser Pro Ser Pro Ser Gln Glu Glu 
    610                 615                 620                 


Leu Gln Thr Thr Leu Glu Glu Thr Asp Gln Ser Thr Gln Glu Pro Phe 
625                 630                 635                 640 


Thr Thr Lys Ile Pro Arg Thr Thr Glu Leu Ala Lys Thr Thr Gln Ala 
                645                 650                 655     


Pro His Arg Phe Tyr Thr Thr Val Arg Pro Arg Thr Ser Asp Lys Pro 
            660                 665                 670         


His Ile Arg Pro Gly Val Lys Gln Ala Pro Arg Pro Ser Gly Ala Asp 
        675                 680                 685             


Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys Lys Pro Gly Thr 
    690                 695                 700                 


Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro Arg Arg Lys Pro 
705                 710                 715                 720 


Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser Ala Gly Ile Ile 
                725                 730                 735     


Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser Thr Pro Arg Pro 
            740                 745                 750         


Thr Gly Thr Pro Leu Glu Arg Ile Glu Thr Asp Ile Lys Gln Pro Thr 
        755                 760                 765             


Val Pro Ala Ser Gly Glu Glu Leu Glu Asn Ile Thr Asp Phe Ser Ser 
    770                 775                 780                 


Ser Pro Thr Arg Glu Thr Asp Pro Leu Gly Lys Pro Arg Phe Lys Gly 
785                 790                 795                 800 


Pro His Val Arg Tyr Ile Gln Lys Pro Asp Asn Ser Pro Cys Ser Ile 
                805                 810                 815     


Thr Asp Ser Val Lys Arg Phe Pro Lys Glu Glu Ala Thr Glu Gly Asn 
            820                 825                 830         


Ala Thr Ser Pro Pro Gln Asn Pro Pro Thr Asn Leu Thr Val Val Thr 
        835                 840                 845             


Val Glu Gly Cys Pro Ser Phe Val Ile Leu Asp Trp Glu Lys Pro Leu 
    850                 855                 860                 


Asn Asp Thr Val Thr Glu Tyr Glu Val Ile Ser Arg Glu Asn Gly Ser 
865                 870                 875                 880 


Phe Ser Gly Lys Asn Lys Ser Ile Gln Met Thr Asn Gln Thr Phe Ser 
                885                 890                 895     


Thr Val Glu Asn Leu Lys Pro Asn Thr Ser Tyr Glu Phe Gln Val Lys 
            900                 905                 910         


Pro Lys Asn Pro Leu Gly Glu Gly Pro Val Ser Asn Thr Val Ala Phe 
        915                 920                 925             


Ser Thr Glu Ser Ala Asp Pro Arg Val Ser Glu Pro Val Ser Ala Gly 
    930                 935                 940                 


Arg Asp Ala Ile Trp Thr Glu Arg Pro Phe Asn Ser Asp Ser Tyr Ser 
945                 950                 955                 960 


Glu Cys Lys Gly Lys Gln Tyr Val Lys Arg Thr Trp Tyr Lys Lys Phe 
                965                 970                 975     


Val Gly Val Gln Leu Cys Asn Ser Leu Arg Tyr Lys Ile Tyr Leu Ser 
            980                 985                 990         


Asp Ser Leu Thr Gly Lys Phe Tyr  Asn Ile Gly Asp Gln  Arg Gly His 
        995                 1000                 1005             


Gly Glu  Asp His Cys Gln Phe  Val Asp Ser Phe Leu  Asp Gly Arg 
    1010                 1015                 1020             


Thr Gly  Gln Gln Leu Thr Ser  Asp Gln Leu Pro Ile  Lys Glu Gly 
    1025                 1030                 1035             


Tyr Phe  Arg Ala Val Arg Gln  Glu Pro Val Gln Phe  Gly Glu Ile 
    1040                 1045                 1050             


Gly Gly  His Thr Gln Ile Asn  Tyr Val Gln Trp Tyr  Glu Cys Gly 
    1055                 1060                 1065             


Thr Thr  Ile Pro Gly Lys Trp  
    1070                 1075 


<210>  83
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABI3__Homo_sapiens__NP_001128658

<400>  83

Met Ala Glu Leu Gln Gln Leu Gln Glu Phe Glu Ile Pro Thr Gly Arg 
1               5                   10                  15      


Glu Ala Leu Arg Gly Asn His Ser Ala Leu Leu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asp Asn Tyr Val Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Met Ala Phe Thr Thr Gln Ala Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Val Gly Asn Leu Ala Gly His Thr Leu Arg Met Leu Asp Leu Gln Gly 
65                  70                  75                  80  


Ala Ala Leu Arg Gln Val Glu Ala Arg Met Val Asn Met His Met Glu 
                85                  90                  95      


Lys Val Ala Arg Arg Glu Ile Gly Thr Leu Ala Thr Val Gln Arg Leu 
            100                 105                 110         


Pro Pro Gly Gln Lys Val Ile Ala Pro Glu Asn Leu Pro Pro Leu Thr 
        115                 120                 125             


Pro Tyr Cys Arg Arg Pro Leu Asn Phe Gly Cys Leu Asp Asp Ile Gly 
    130                 135                 140                 


His Gly Ile Lys Asp Leu Ser Thr Gln Leu Ser Arg Thr Gly Thr Leu 
145                 150                 155                 160 


Ser Arg Lys Ser Ile Lys Ala Pro Ala Thr Pro Ala Ser Ala Thr Leu 
                165                 170                 175     


Gly Arg Pro Pro Arg Ile Pro Glu Pro Val His Leu Pro Val Val Pro 
            180                 185                 190         


Asp Gly Arg Leu Ser Ala Ala Ser Ser Ala Ser Ser Leu Ala Ser Ala 
        195                 200                 205             


Gly Ser Ala Glu Gly Val Gly Gly Ala Pro Thr Pro Lys Gly Gln Ala 
    210                 215                 220                 


Ala Pro Pro Ala Pro Pro Leu Pro Ser Ser Leu Asp Pro Pro Pro Pro 
225                 230                 235                 240 


Pro Ala Ala Val Glu Val Phe Gln Arg Pro Pro Thr Leu Glu Glu Leu 
                245                 250                 255     


Ser Pro Pro Pro Pro Asp Glu Glu Leu Pro Leu Pro Leu Asp Leu Pro 
            260                 265                 270         


Pro Pro Pro Pro Leu Asp Gly Asp Glu Leu Gly Leu Pro Pro Pro Pro 
        275                 280                 285             


Pro Gly Phe Gly Pro Asp Glu Pro Ser Trp Val Pro Ala Ser Tyr Leu 
    290                 295                 300                 


Glu Lys Val Val Thr Leu Tyr Pro Tyr Thr Ser Gln Lys Asp Asn Glu 
305                 310                 315                 320 


Leu Ser Phe Ser Glu Gly Thr Val Ile Cys Val Thr Arg Arg Tyr Ser 
                325                 330                 335     


Asp Gly Trp Cys Glu Gly Val Ser Ser Glu Gly Thr Gly Phe Phe Pro 
            340                 345                 350         


Gly Asn Tyr Val Glu Pro Ser Cys 
        355                 360 


<210>  84
<211>  1130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABL1__Homo_sapiens__NP_005148

<400>  84

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  85
<211>  1064
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABL2__Homo_sapiens__NP_001129472

<400>  85

Met Val Leu Gly Thr Val Leu Leu Pro Pro Asn Ser Tyr Gly Arg Asp 
1               5                   10                  15      


Gln Asp Thr Ser Leu Cys Cys Leu Cys Thr Glu Ala Ser Glu Ser Ala 
            20                  25                  30          


Leu Pro Asp Leu Thr Asp His Phe Ala Ser Cys Val Glu Asp Gly Phe 
        35                  40                  45              


Glu Gly Asp Lys Thr Gly Gly Ser Ser Pro Glu Ala Leu His Arg Pro 
    50                  55                  60                  


Tyr Gly Cys Asp Val Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp 
65                  70                  75                  80  


Ser Ser Lys Glu Asn Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu 
                85                  90                  95      


Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser 
            100                 105                 110         


Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly 
        115                 120                 125             


Glu Trp Ser Glu Val Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser 
    130                 135                 140                 


Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr His 
145                 150                 155                 160 


Gly Pro Val Ser Arg Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile 
                165                 170                 175     


Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu 
            180                 185                 190         


Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn 
        195                 200                 205             


Thr Thr Ala Asp Gly Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser 
    210                 215                 220                 


Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly Leu 
225                 230                 235                 240 


Val Thr Thr Leu His Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val 
                245                 250                 255     


Tyr Gly Val Ser Pro Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp 
            260                 265                 270         


Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr 
        275                 280                 285             


Val Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu 
    290                 295                 300                 


Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val 
305                 310                 315                 320 


Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val Cys 
                325                 330                 335     


Thr Leu Glu Pro Pro Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly 
            340                 345                 350         


Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala 
        355                 360                 365             


Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr 
    370                 375                 380                 


Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys 
385                 390                 395                 400 


Leu Val Gly Glu Asn His Val Val Lys Val Ala Asp Phe Gly Leu Ser 
                405                 410                 415     


Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe 
            420                 425                 430         


Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser 
        435                 440                 445             


Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala 
    450                 455                 460                 


Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr 
465                 470                 475                 480 


Asp Leu Leu Glu Lys Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro 
                485                 490                 495     


Pro Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala 
            500                 505                 510         


Asp Arg Pro Ser Phe Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe 
        515                 520                 525             


His Asp Ser Ser Ile Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala 
    530                 535                 540                 


Ala Ser Ser Ser Ser Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu 
545                 550                 555                 560 


Pro Ser Lys Thr Arg Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn 
                565                 570                 575     


Ile Glu Gly Ala Gln Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala 
            580                 585                 590         


Pro Gly Phe Ile Arg Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu 
        595                 600                 605             


Pro Arg Lys Gln Arg Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala 
    610                 615                 620                 


Lys Glu Thr Cys Phe Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser 
625                 630                 635                 640 


Phe Met Lys Lys Arg Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser 
                645                 650                 655     


Phe Arg Glu Met Glu Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly 
            660                 665                 670         


Leu Pro Glu Gln Asp Arg Met Ala Met Thr Leu Pro Arg Asn Cys Gln 
        675                 680                 685             


Arg Ser Lys Leu Gln Leu Glu Arg Thr Val Ser Thr Ser Ser Gln Pro 
    690                 695                 700                 


Glu Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys Ser Glu 
705                 710                 715                 720 


Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu Leu Pro 
                725                 730                 735     


Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr Pro Ser Gly Asp Leu Ala 
            740                 745                 750         


Ile Thr Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val Ala Ala 
        755                 760                 765             


Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly Met Ala 
    770                 775                 780                 


Gly Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro Ala Lys 
785                 790                 795                 800 


Ala Ala Pro Val Leu Pro Thr Thr His Asn His Lys Val Pro Val Leu 
                805                 810                 815     


Ile Ser Pro Thr Leu Lys His Thr Pro Ala Asp Val Gln Leu Ile Gly 
            820                 825                 830         


Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His Gln Val 
        835                 840                 845             


Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro Lys Cys 
    850                 855                 860                 


Ala Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro Ser Ile 
865                 870                 875                 880 


Cys Ser Asp Pro Thr Glu Glu Pro Thr Ala Leu Thr Ala Gly Gln Ser 
                885                 890                 895     


Thr Ser Glu Thr Gln Glu Gly Gly Lys Lys Ala Ala Leu Gly Ala Val 
            900                 905                 910         


Pro Ile Ser Gly Lys Ala Gly Arg Pro Val Met Pro Pro Pro Gln Val 
        915                 920                 925             


Pro Leu Pro Thr Ser Ser Ile Ser Pro Ala Lys Met Ala Asn Gly Thr 
    930                 935                 940                 


Ala Gly Thr Lys Val Ala Leu Arg Lys Thr Lys Gln Ala Ala Glu Lys 
945                 950                 955                 960 


Ile Ser Ala Asp Lys Ile Ser Lys Glu Ala Leu Leu Glu Cys Ala Asp 
                965                 970                 975     


Leu Leu Ser Ser Ala Leu Thr Glu Pro Val Pro Asn Ser Gln Leu Val 
            980                 985                 990         


Asp Thr Gly His Gln Leu Leu Asp  Tyr Cys Ser Gly Tyr  Val Asp Cys 
        995                 1000                 1005             


Ile Pro  Gln Thr Arg Asn Lys  Phe Ala Phe Arg Glu  Ala Val Ser 
    1010                 1015                 1020             


Lys Leu  Glu Leu Ser Leu Gln  Glu Leu Gln Val Ser  Ser Ala Ala 
    1025                 1030                 1035             


Ala Gly  Val Pro Gly Thr Asn  Pro Val Leu Asn Asn  Leu Leu Ser 
    1040                 1045                 1050             


Cys Val  Gln Glu Ile Ser Asp  Val Val Gln Arg 
    1055                 1060                 


<210>  86
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABLIM1__Homo_sapiens__NP_001003407

<400>  86

Met Leu Met Thr Leu Glu Met Thr Glu Leu Thr Asp Pro His His Thr 
1               5                   10                  15      


Met Gly Asp Tyr Lys Val Ala His Pro Gln Asp Pro His His Pro Ser 
            20                  25                  30          


Glu Lys Pro Val Ile His Cys His Lys Cys Gly Glu Pro Cys Lys Gly 
        35                  40                  45              


Glu Val Leu Arg Val Gln Thr Lys His Phe His Ile Lys Cys Phe Thr 
    50                  55                  60                  


Cys Lys Val Cys Gly Cys Asp Leu Ala Gln Gly Gly Phe Phe Ile Lys 
65                  70                  75                  80  


Asn Gly Glu Tyr Leu Cys Thr Leu Asp Tyr Gln Arg Met Tyr Gly Thr 
                85                  90                  95      


Arg Cys His Gly Cys Gly Glu Phe Val Glu Gly Glu Val Val Thr Ala 
            100                 105                 110         


Leu Gly Lys Thr Tyr His Pro Asn Cys Phe Ala Cys Thr Ile Cys Lys 
        115                 120                 125             


Arg Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Arg Asp Cys 
    130                 135                 140                 


Leu Cys Gln Leu Cys Ala Gln Pro Met Ser Ser Ser Pro Lys Glu Thr 
145                 150                 155                 160 


Thr Phe Ser Ser Asn Cys Ala Gly Cys Gly Arg Asp Ile Lys Asn Gly 
                165                 170                 175     


Gln Ala Leu Leu Ala Leu Asp Lys Gln Trp His Leu Gly Cys Phe Lys 
            180                 185                 190         


Cys Lys Ser Cys Gly Lys Val Leu Thr Gly Glu Tyr Ile Ser Lys Asp 
        195                 200                 205             


Gly Ala Pro Tyr Cys Glu Lys Asp Tyr Gln Gly Leu Phe Gly Val Lys 
    210                 215                 220                 


Cys Glu Ala Cys His Gln Phe Ile Thr Gly Lys Val Leu Glu Ala Gly 
225                 230                 235                 240 


Asp Lys His Tyr His Pro Ser Cys Ala Arg Cys Ser Arg Cys Asn Gln 
                245                 250                 255     


Met Phe Thr Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Thr Val Trp 
            260                 265                 270         


His Pro Asp Cys Lys Gln Ser Thr Lys Thr Glu Glu Lys Leu Arg Pro 
        275                 280                 285             


Thr Arg Thr Ser Ser Glu Ser Ile Tyr Ser Arg Pro Gly Ser Ser Ile 
    290                 295                 300                 


Pro Gly Ser Pro Gly His Thr Ile Tyr Ala Lys Val Asp Asn Glu Ile 
305                 310                 315                 320 


Leu Asp Tyr Lys Asp Leu Ala Ala Ile Pro Lys Val Lys Ala Ile Tyr 
                325                 330                 335     


Asp Ile Glu Arg Pro Asp Leu Ile Thr Tyr Glu Pro Phe Tyr Thr Ser 
            340                 345                 350         


Gly Tyr Asp Asp Lys Gln Glu Arg Gln Ser Leu Gly Glu Ser Pro Arg 
        355                 360                 365             


Thr Leu Ser Pro Thr Pro Ser Ala Glu Gly Tyr Gln Asp Val Arg Asp 
    370                 375                 380                 


Arg Met Ile His Arg Ser Thr Ser Gln Gly Ser Ile Asn Ser Pro Val 
385                 390                 395                 400 


Tyr Ser Arg His Ser Tyr Thr Pro Thr Thr Ser Arg Ser Pro Gln His 
                405                 410                 415     


Phe His Arg Pro Gly Asn Glu Pro Ser Ser Gly Arg Asn Ser Pro Leu 
            420                 425                 430         


Pro Tyr Arg Pro Asp Ser Arg Pro Leu Thr Pro Thr Tyr Ala Gln Ala 
        435                 440                 445             


Pro Lys His Phe His Val Pro Asp Gln Gly Ile Asn Ile Tyr Arg Lys 
    450                 455                 460                 


Pro Pro Ile Tyr Lys Gln His Ala Ala Leu Ala Ala Gln Ser Lys Ser 
465                 470                 475                 480 


Ser Glu Asp Ile Ile Lys Phe Ser Lys Phe Pro Ala Ala Gln Ala Pro 
                485                 490                 495     


Asp Pro Ser Glu Thr Pro Lys Ile Glu Thr Asp His Trp Pro Gly Pro 
            500                 505                 510         


Pro Ser Phe Ala Val Val Gly Pro Asp Met Lys Arg Arg Ser Ser Gly 
        515                 520                 525             


Arg Glu Glu Asp Asp Glu Glu Leu Leu Arg Arg Arg Gln Leu Gln Glu 
    530                 535                 540                 


Glu Gln Leu Met Lys Leu Asn Ser Gly Leu Gly Gln Leu Ile Leu Lys 
545                 550                 555                 560 


Glu Glu Met Glu Lys Glu Ser Arg Glu Arg Ser Ser Leu Leu Ala Ser 
                565                 570                 575     


Arg Tyr Asp Ser Pro Ile Asn Ser Ala Ser His Ile Pro Ser Ser Lys 
            580                 585                 590         


Thr Ala Ser Leu Pro Gly Tyr Gly Arg Asn Gly Leu His Arg Pro Val 
        595                 600                 605             


Ser Thr Asp Phe Ala Gln Tyr Asn Ser Tyr Gly Asp Val Ser Gly Gly 
    610                 615                 620                 


Val Arg Asp Tyr Gln Thr Leu Pro Asp Gly His Met Pro Ala Met Arg 
625                 630                 635                 640 


Met Asp Arg Gly Val Ser Met Pro Asn Met Leu Glu Pro Lys Ile Phe 
                645                 650                 655     


Pro Tyr Glu Met Leu Met Val Thr Asn Arg Gly Arg Asn Lys Ile Leu 
            660                 665                 670         


Arg Glu Val Asp Arg Thr Arg Leu Glu Arg His Leu Ala Pro Glu Val 
        675                 680                 685             


Phe Arg Glu Ile Phe Gly Met Ser Ile Gln Glu Phe Asp Arg Leu Pro 
    690                 695                 700                 


Leu Trp Arg Arg Asn Asp Met Lys Lys Lys Ala Lys Leu Phe 
705                 710                 715             


<210>  87
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABLIM2__Homo_sapiens__NP_001123555

<400>  87

Met Ser Ala Val Ser Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys 
1               5                   10                  15      


Ser Pro Ser Thr Ala Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys 
            20                  25                  30          


Gly Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe 
        35                  40                  45              


Val Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val 
    50                  55                  60                  


Arg Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly 
65                  70                  75                  80  


Thr Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser 
                85                  90                  95      


Ala Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys 
            100                 105                 110         


Arg Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu 
        115                 120                 125             


Cys Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala 
    130                 135                 140                 


His Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile 
145                 150                 155                 160 


Lys Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly 
                165                 170                 175     


Cys Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile 
            180                 185                 190         


Ser Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe 
        195                 200                 205             


Gly Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu 
    210                 215                 220                 


Glu Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg 
225                 230                 235                 240 


Cys Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser 
                245                 250                 255     


Ser Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg 
            260                 265                 270         


Asn Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala 
        275                 280                 285             


Ser Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly 
    290                 295                 300                 


Gly Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys 
305                 310                 315                 320 


Ala Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr 
                325                 330                 335     


Ile Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln 
            340                 345                 350         


Asp Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr 
        355                 360                 365             


Gly Ser Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln 
    370                 375                 380                 


His Tyr Ser Arg Pro Ala Gly Thr Val Ser Val Gly Thr Ser Ser Cys 
385                 390                 395                 400 


Leu Ser Leu Ser Gln His Pro Ser Pro Thr Ser Val Phe Arg His His 
                405                 410                 415     


Tyr Ile Pro Tyr Phe Arg Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser 
            420                 425                 430         


Leu Ser Val Leu Ser Asp Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln 
        435                 440                 445             


Ala Pro Arg His Phe His Val Pro Asp Thr Gly Val Lys Asp Asn Ile 
    450                 455                 460                 


Tyr Arg Lys Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp 
465                 470                 475                 480 


Gly Glu Asp Gly Ser Leu Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser 
                485                 490                 495     


Trp Leu Met Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp 
            500                 505                 510         


Leu Asp Thr Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro 
        515                 520                 525             


Leu Gln Arg Met Ala Gly Asp Ser Phe His Ser Arg Phe Pro Tyr Ser 
    530                 535                 540                 


Lys Ser Asp Pro Leu Pro Gly His Gly Lys Asn Gly Leu Asp Gln Arg 
545                 550                 555                 560 


Asn Ala Asn Leu Ala Pro Cys Gly Ala Asp Pro Asp Ala Ser Trp Gly 
                565                 570                 575     


Met Arg Glu Tyr Lys Ile Tyr Pro Tyr Asp Ser Leu Ile Val Thr Asn 
            580                 585                 590         


Arg Ile Arg Val Lys Leu Pro Lys Asp Val Asp Arg Thr Arg Leu Glu 
        595                 600                 605             


Arg His Leu Ser Pro Glu Glu Phe Gln Glu Val Phe Gly Met Ser Ile 
    610                 615                 620                 


Glu Glu Phe Asp Arg Leu Ala Leu Trp Lys Arg Asn Asp Leu Lys Lys 
625                 630                 635                 640 


Lys Ala Leu Leu Phe 
                645 


<210>  88
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABO__Homo_sapiens__NP_065202

<400>  88

Met Ala Glu Val Leu Arg Thr Leu Ala Gly Lys Pro Lys Cys His Ala 
1               5                   10                  15      


Leu Arg Pro Met Ile Leu Phe Leu Ile Met Leu Val Leu Val Leu Phe 
            20                  25                  30          


Gly Tyr Gly Val Leu Ser Pro Arg Ser Leu Met Pro Gly Ser Leu Glu 
        35                  40                  45              


Arg Gly Phe Cys Met Ala Val Arg Glu Pro Asp His Leu Gln Arg Val 
    50                  55                  60                  


Ser Leu Pro Arg Met Val Tyr Pro Gln Pro Lys Val Leu Thr Pro Cys 
65                  70                  75                  80  


Arg Lys Asp Val Leu Val Val Thr Pro Trp Leu Ala Pro Ile Val Trp 
                85                  90                  95      


Glu Gly Thr Phe Asn Ile Asp Ile Leu Asn Glu Gln Phe Arg Leu Gln 
            100                 105                 110         


Asn Thr Thr Ile Gly Leu Thr Val Phe Ala Ile Lys Lys Tyr Val Ala 
        115                 120                 125             


Phe Leu Lys Leu Phe Leu Glu Thr Ala Glu Lys His Phe Met Val Gly 
    130                 135                 140                 


His Arg Val His Tyr Tyr Val Phe Thr Asp Gln Pro Ala Ala Val Pro 
145                 150                 155                 160 


Arg Val Thr Leu Gly Thr Gly Arg Gln Leu Ser Val Leu Glu Val Arg 
                165                 170                 175     


Ala Tyr Lys Arg Trp Gln Asp Val Ser Met Arg Arg Met Glu Met Ile 
            180                 185                 190         


Ser Asp Phe Cys Glu Arg Arg Phe Leu Ser Glu Val Asp Tyr Leu Val 
        195                 200                 205             


Cys Val Asp Val Asp Met Glu Phe Arg Asp His Val Gly Val Glu Ile 
    210                 215                 220                 


Leu Thr Pro Leu Phe Gly Thr Leu His Pro Gly Phe Tyr Gly Ser Ser 
225                 230                 235                 240 


Arg Glu Ala Phe Thr Tyr Glu Arg Arg Pro Gln Ser Gln Ala Tyr Ile 
                245                 250                 255     


Pro Lys Asp Glu Gly Asp Phe Tyr Tyr Leu Gly Gly Phe Phe Gly Gly 
            260                 265                 270         


Ser Val Gln Glu Val Gln Arg Leu Thr Arg Ala Cys His Gln Ala Met 
        275                 280                 285             


Met Val Asp Gln Ala Asn Gly Ile Glu Ala Val Trp His Asp Glu Ser 
    290                 295                 300                 


His Leu Asn Lys Tyr Leu Leu Arg His Lys Pro Thr Lys Val Leu Ser 
305                 310                 315                 320 


Pro Glu Tyr Leu Trp Asp Gln Gln Leu Leu Gly Trp Pro Ala Val Leu 
                325                 330                 335     


Arg Lys Leu Arg Phe Thr Ala Val Pro Lys Asn His Gln Ala Val Arg 
            340                 345                 350         


Asn Pro 
        


<210>  89
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABRA__Homo_sapiens__NP_631905

<400>  89

Met Ala Pro Gly Glu Lys Glu Ser Gly Glu Gly Pro Ala Lys Ser Ala 
1               5                   10                  15      


Leu Arg Lys Ile Arg Thr Ala Thr Leu Val Ile Ser Leu Ala Arg Gly 
            20                  25                  30          


Trp Gln Gln Trp Ala Asn Glu Asn Ser Ile Arg Gln Ala Gln Glu Pro 
        35                  40                  45              


Thr Gly Trp Leu Pro Gly Gly Thr Gln Asp Ser Pro Gln Ala Pro Lys 
    50                  55                  60                  


Pro Ile Thr Pro Pro Thr Ser His Gln Lys Ala Gln Ser Ala Pro Lys 
65                  70                  75                  80  


Ser Pro Pro Arg Leu Pro Glu Gly His Gly Asp Gly Gln Ser Ser Glu 
                85                  90                  95      


Lys Ala Pro Glu Val Ser His Ile Lys Lys Lys Glu Val Ser Lys Thr 
            100                 105                 110         


Val Val Ser Lys Thr Tyr Glu Arg Gly Gly Asp Val Ser His Leu Ser 
        115                 120                 125             


His Arg Tyr Glu Arg Asp Ala Gly Val Leu Glu Pro Gly Gln Pro Glu 
    130                 135                 140                 


Asn Asp Ile Asp Arg Ile Leu His Ser His Gly Ser Pro Thr Arg Arg 
145                 150                 155                 160 


Arg Lys Cys Ala Asn Leu Val Ser Glu Leu Thr Lys Gly Trp Arg Val 
                165                 170                 175     


Met Glu Gln Glu Glu Pro Thr Trp Arg Ser Asp Ser Val Asp Thr Glu 
            180                 185                 190         


Asp Ser Gly Tyr Gly Gly Glu Ala Glu Glu Arg Pro Glu Gln Asp Gly 
        195                 200                 205             


Val Gln Val Ala Val Val Arg Ile Lys Arg Pro Leu Pro Ser Gln Val 
    210                 215                 220                 


Asn Arg Phe Thr Glu Lys Leu Asn Cys Lys Ala Gln Gln Lys Tyr Ser 
225                 230                 235                 240 


Pro Val Gly Asn Leu Lys Gly Arg Trp Gln Gln Trp Ala Asp Glu His 
                245                 250                 255     


Ile Gln Ser Gln Lys Leu Asn Pro Phe Ser Glu Glu Phe Asp Tyr Glu 
            260                 265                 270         


Leu Ala Met Ser Thr Arg Leu His Lys Gly Asp Glu Gly Tyr Gly Arg 
        275                 280                 285             


Pro Lys Glu Gly Thr Lys Thr Ala Glu Arg Ala Lys Arg Ala Glu Glu 
    290                 295                 300                 


His Ile Tyr Arg Glu Met Met Asp Met Cys Phe Ile Ile Cys Thr Met 
305                 310                 315                 320 


Ala Arg His Arg Arg Asp Gly Lys Ile Gln Val Thr Phe Gly Asp Leu 
                325                 330                 335     


Phe Asp Arg Tyr Val Arg Ile Ser Asp Lys Val Val Gly Ile Leu Met 
            340                 345                 350         


Arg Ala Arg Lys His Gly Leu Val Asp Phe Glu Gly Glu Met Leu Trp 
        355                 360                 365             


Gln Gly Arg Asp Asp His Val Val Ile Thr Leu Leu Lys 
    370                 375                 380     


<210>  90
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABR__Homo_sapiens__NP_001153218

<400>  90

Met Pro Tyr Ile Asp Glu Ser Pro Thr Met Ser Pro Gln Leu Ser Ala 
1               5                   10                  15      


Arg Ser Gln Gly Gly Gly Asp Gly Val Ser Pro Thr Pro Pro Glu Gly 
            20                  25                  30          


Leu Ala Pro Gly Val Glu Ala Gly Lys Gly Leu Glu Met Arg Lys Leu 
        35                  40                  45              


Val Leu Ser Gly Phe Leu Ala Ser Glu Glu Ile Tyr Ile Asn Gln Leu 
    50                  55                  60                  


Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys Ala Thr Ala Thr Thr 
65                  70                  75                  80  


Ser Gln Pro Val Leu Thr Ile Gln Gln Ile Glu Thr Ile Phe Tyr Lys 
                85                  90                  95      


Ile Gln Asp Ile Tyr Glu Ile His Lys Glu Phe Tyr Asp Asn Leu Cys 
            100                 105                 110         


Pro Lys Val Gln Gln Trp Asp Ser Gln Val Thr Met Gly His Leu Phe 
        115                 120                 125             


Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Lys Ala Phe Val Asp Asn 
    130                 135                 140                 


Tyr Lys Val Ala Leu Glu Thr Ala Glu Lys Cys Ser Gln Ser Asn Asn 
145                 150                 155                 160 


Gln Phe Gln Lys Ile Ser Glu Glu Leu Lys Val Lys Gly Pro Lys Asp 
                165                 170                 175     


Ser Lys Asp Ser His Thr Ser Val Thr Met Glu Ala Leu Leu Tyr Lys 
            180                 185                 190         


Pro Ile Asp Arg Val Thr Arg Ser Thr Leu Val Leu His Asp Leu Leu 
        195                 200                 205             


Lys His Thr Pro Val Asp His Pro Asp Tyr Pro Leu Leu Gln Asp Ala 
    210                 215                 220                 


Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile Asn Glu Asp Ile Asp 
225                 230                 235                 240 


Pro Arg Arg Thr Ala Val Thr Thr Pro Lys Gly Glu Thr Arg Gln Leu 
                245                 250                 255     


Val Lys Asp Gly Phe Leu Val Glu Val Ser Glu Ser Ser Arg Lys Leu 
            260                 265                 270         


Arg His Val Phe Leu Phe Thr Asp Val Leu Leu Cys Ala Lys Leu Lys 
        275                 280                 285             


Lys Thr Ser Ala Gly Lys His Gln Gln Tyr Asp Cys Lys Trp Tyr Ile 
    290                 295                 300                 


Pro Leu Ala Asp Leu Val Phe Pro Ser Pro Glu Glu Ser Glu Ala Ser 
305                 310                 315                 320 


Pro Gln Val His Pro Phe Pro Asp His Glu Leu Glu Asp Met Lys Met 
                325                 330                 335     


Lys Ile Ser Ala Leu Lys Ser Glu Ile Gln Lys Glu Lys Ala Asn Lys 
            340                 345                 350         


Gly Gln Ser Arg Ala Ile Glu Arg Leu Lys Lys Lys Met Phe Glu Asn 
        355                 360                 365             


Glu Phe Leu Leu Leu Leu Asn Ser Pro Thr Ile Pro Phe Arg Ile His 
    370                 375                 380                 


Asn Arg Asn Gly Lys Ser Tyr Leu Phe Leu Leu Ser Ser Asp Tyr Glu 
385                 390                 395                 400 


Arg Ser Glu Trp Arg Glu Ala Ile Gln Lys Leu Gln Lys Lys Asp Leu 
                405                 410                 415     


Gln Ala Phe Val Leu Ser Ser Val Glu Leu Gln Val Leu Thr Gly Ser 
            420                 425                 430         


Cys Phe Lys Leu Arg Thr Val His Asn Ile Pro Val Thr Ser Asn Lys 
        435                 440                 445             


Asp Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe Leu His Val Ile Val 
    450                 455                 460                 


His Ser Ala Lys Gly Phe Lys Gln Ser Ala Asn Leu Tyr Cys Thr Leu 
465                 470                 475                 480 


Glu Val Asp Ser Phe Gly Tyr Phe Val Ser Lys Ala Lys Thr Arg Val 
                485                 490                 495     


Phe Arg Asp Thr Ala Glu Pro Lys Trp Asp Glu Glu Phe Glu Ile Glu 
            500                 505                 510         


Leu Glu Gly Ser Gln Ser Leu Arg Ile Leu Cys Tyr Glu Lys Cys Tyr 
        515                 520                 525             


Asp Lys Thr Lys Val Asn Lys Asp Asn Asn Glu Ile Val Asp Lys Ile 
    530                 535                 540                 


Met Gly Lys Gly Gln Ile Gln Leu Asp Pro Gln Thr Val Glu Thr Lys 
545                 550                 555                 560 


Asn Trp His Thr Asp Val Ile Glu Met Asn Gly Ile Lys Val Glu Phe 
                565                 570                 575     


Ser Met Lys Phe Thr Ser Arg Asp Met Ser Leu Lys Arg Thr Pro Ser 
            580                 585                 590         


Lys Lys Gln Thr Gly Val Phe Gly Val Lys Ile Ser Val Val Thr Lys 
        595                 600                 605             


Arg Glu Arg Ser Lys Val Pro Tyr Ile Val Arg Gln Cys Val Glu Glu 
    610                 615                 620                 


Val Glu Lys Arg Gly Ile Glu Glu Val Gly Ile Tyr Arg Ile Ser Gly 
625                 630                 635                 640 


Val Ala Thr Asp Ile Gln Ala Leu Lys Ala Val Phe Asp Ala Asn Asn 
                645                 650                 655     


Lys Asp Ile Leu Leu Met Leu Ser Asp Met Asp Ile Asn Ala Ile Ala 
            660                 665                 670         


Gly Thr Leu Lys Leu Tyr Phe Arg Glu Leu Pro Glu Pro Leu Leu Thr 
        675                 680                 685             


Asp Arg Leu Tyr Pro Ala Phe Met Glu Gly Ile Ala Leu Ser Asp Pro 
    690                 695                 700                 


Ala Ala Lys Glu Asn Cys Met Met His Leu Leu Arg Ser Leu Pro Asp 
705                 710                 715                 720 


Pro Asn Leu Ile Thr Phe Leu Phe Leu Leu Glu His Leu Lys Arg Val 
                725                 730                 735     


Ala Glu Lys Glu Pro Ile Asn Lys Met Ser Leu His Asn Leu Ala Thr 
            740                 745                 750         


Val Phe Gly Pro Thr Leu Leu Arg Pro Ser Glu Val Glu Ser Lys Ala 
        755                 760                 765             


His Leu Thr Ser Ala Ala Asp Ile Trp Ser His Asp Val Met Ala Gln 
    770                 775                 780                 


Val Gln Val Leu Leu Tyr Tyr Leu Gln His Pro Pro Ile Ser Phe Ala 
785                 790                 795                 800 


Glu Leu Lys Arg Asn Thr Leu Tyr Phe Ser Thr Asp Val 
                805                 810             


<210>  91
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABT1__Homo_sapiens__NP_037507

<400>  91

Met Glu Ala Glu Glu Ser Glu Lys Ala Ala Thr Glu Gln Glu Pro Leu 
1               5                   10                  15      


Glu Gly Thr Glu Gln Thr Leu Asp Ala Glu Glu Glu Gln Glu Glu Ser 
            20                  25                  30          


Glu Glu Ala Ala Cys Gly Ser Lys Lys Arg Val Val Pro Gly Ile Val 
        35                  40                  45              


Tyr Leu Gly His Ile Pro Pro Arg Phe Arg Pro Leu His Val Arg Asn 
    50                  55                  60                  


Leu Leu Ser Ala Tyr Gly Glu Val Gly Arg Val Phe Phe Gln Ala Glu 
65                  70                  75                  80  


Asp Arg Phe Val Arg Arg Lys Lys Lys Ala Ala Ala Ala Ala Gly Gly 
                85                  90                  95      


Lys Lys Arg Ser Tyr Thr Lys Asp Tyr Thr Glu Gly Trp Val Glu Phe 
            100                 105                 110         


Arg Asp Lys Arg Ile Ala Lys Arg Val Ala Ala Ser Leu His Asn Thr 
        115                 120                 125             


Pro Met Gly Ala Arg Arg Arg Ser Pro Phe Arg Tyr Asp Leu Trp Asn 
    130                 135                 140                 


Leu Lys Tyr Leu His Arg Phe Thr Trp Ser His Leu Ser Glu His Leu 
145                 150                 155                 160 


Ala Phe Glu Arg Gln Val Arg Arg Gln Arg Leu Arg Ala Glu Val Ala 
                165                 170                 175     


Gln Ala Lys Arg Glu Thr Asp Phe Tyr Leu Gln Ser Val Glu Arg Gly 
            180                 185                 190         


Gln Arg Phe Leu Ala Ala Asp Gly Asp Pro Ala Arg Pro Asp Gly Ser 
        195                 200                 205             


Trp Thr Phe Ala Gln Arg Pro Thr Glu Gln Glu Leu Arg Ala Arg Lys 
    210                 215                 220                 


Ala Ala Arg Pro Gly Gly Arg Glu Arg Ala Arg Leu Ala Thr Ala Gln 
225                 230                 235                 240 


Asp Lys Ala Arg Ser Asn Lys Gly Leu Leu Ala Arg Ile Phe Gly Ala 
                245                 250                 255     


Pro Pro Pro Ser Glu Ser Met Glu Gly Pro Ser Leu Val Arg Asp Ser 
            260                 265                 270         


<210>  92
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAA1__Homo_sapiens__NP_001123882

<400>  92

Met Gln Arg Leu Gln Val Val Leu Gly His Leu Arg Gly Pro Ala Asp 
1               5                   10                  15      


Ser Gly Trp Met Pro Gln Ala Ala Pro Cys Leu Ser Gly Ala Pro Gln 
            20                  25                  30          


Ala Ser Ala Ala Asp Val Val Val Val His Gly Arg Arg Thr Ala Ile 
        35                  40                  45              


Cys Arg Ala Gly Arg Gly Gly Phe Lys Asp Thr Thr Pro Asp Glu Leu 
    50                  55                  60                  


Leu Ser Ala Val Met Thr Ala Val Leu Lys Asp Val Asn Leu Arg Pro 
65                  70                  75                  80  


Glu Gln Leu Gly Asp Ile Cys Val Gly Asn Val Leu Gln Pro Gly Ala 
                85                  90                  95      


Gly Ala Ile Met Ala Arg Ile Ala Gln Phe Leu Ser Asp Ile Pro Glu 
            100                 105                 110         


Thr Val Pro Leu Ser Thr Val Asn Arg Gln Cys Ser Ser Gly Leu Gln 
        115                 120                 125             


Ala Val Ala Ser Ile Ala Gly Gly Ile Arg Asn Gly Ser Tyr Asp Ile 
    130                 135                 140                 


Gly Met Ala Cys Gly Ile Thr Ser Glu Asn Val Ala Glu Arg Phe Gly 
145                 150                 155                 160 


Ile Ser Arg Glu Lys Gln Asp Thr Phe Ala Leu Ala Ser Gln Gln Lys 
                165                 170                 175     


Ala Ala Arg Ala Gln Ser Lys Gly Cys Phe Gln Ala Glu Ile Val Pro 
            180                 185                 190         


Val Thr Thr Thr Val His Asp Asp Lys Gly Thr Lys Arg Ser Ile Thr 
        195                 200                 205             


Val Thr Gln Asp Glu Gly Ile Arg Pro Ser Thr Thr Met Glu Gly Leu 
    210                 215                 220                 


Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Ser Thr Thr Ala Gly 
225                 230                 235                 240 


Leu Thr Val Ser Asp Val Asp Ile Phe Glu Ile Asn Glu Ala Phe Ala 
                245                 250                 255     


Ser Gln Ala Ala Tyr Cys Val Glu Lys Leu Arg Leu Pro Pro Glu Lys 
            260                 265                 270         


Val Asn Pro Leu Gly Gly Ala Val Ala Leu Gly His Pro Leu Gly Cys 
        275                 280                 285             


Thr Gly Ala Arg Gln Val Ile Thr Leu Leu Asn Glu Leu Lys Arg Arg 
    290                 295                 300                 


Gly Lys Arg Ala Tyr Gly Val Val Ser Met Cys Ile Gly Thr Gly Met 
305                 310                 315                 320 


Gly Ala Ala Ala Val Phe Glu Tyr Pro Gly Asn 
                325                 330     


<210>  93
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAA2__Homo_sapiens__NP_006102

<400>  93

Met Ala Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Thr Pro 
1               5                   10                  15      


Phe Gly Ala Tyr Gly Gly Leu Leu Lys Asp Phe Thr Ala Thr Asp Leu 
            20                  25                  30          


Ser Glu Phe Ala Ala Lys Ala Ala Leu Ser Ala Gly Lys Val Ser Pro 
        35                  40                  45              


Glu Thr Val Asp Ser Val Ile Met Gly Asn Val Leu Gln Ser Ser Ser 
    50                  55                  60                  


Asp Ala Ile Tyr Leu Ala Arg His Val Gly Leu Arg Val Gly Ile Pro 
65                  70                  75                  80  


Lys Glu Thr Pro Ala Leu Thr Ile Asn Arg Leu Cys Gly Ser Gly Phe 
                85                  90                  95      


Gln Ser Ile Val Asn Gly Cys Gln Glu Ile Cys Val Lys Glu Ala Glu 
            100                 105                 110         


Val Val Leu Cys Gly Gly Thr Glu Ser Met Ser Gln Ala Pro Tyr Cys 
        115                 120                 125             


Val Arg Asn Val Arg Phe Gly Thr Lys Leu Gly Ser Asp Ile Lys Leu 
    130                 135                 140                 


Glu Asp Ser Leu Trp Val Ser Leu Thr Asp Gln His Val Gln Leu Pro 
145                 150                 155                 160 


Met Ala Met Thr Ala Glu Asn Leu Ala Val Lys His Lys Ile Ser Arg 
                165                 170                 175     


Glu Glu Cys Asp Lys Tyr Ala Leu Gln Ser Gln Gln Arg Trp Lys Ala 
            180                 185                 190         


Ala Asn Asp Ala Gly Tyr Phe Asn Asp Glu Met Ala Pro Ile Glu Val 
        195                 200                 205             


Lys Thr Lys Lys Gly Lys Gln Thr Met Gln Val Asp Glu His Ala Arg 
    210                 215                 220                 


Pro Gln Thr Thr Leu Glu Gln Leu Gln Lys Leu Pro Pro Val Phe Lys 
225                 230                 235                 240 


Lys Asp Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Val Ala Asp Gly 
                245                 250                 255     


Ala Gly Ala Val Ile Ile Ala Ser Glu Asp Ala Val Lys Lys His Asn 
            260                 265                 270         


Phe Thr Pro Leu Ala Arg Ile Val Gly Tyr Phe Val Ser Gly Cys Asp 
        275                 280                 285             


Pro Ser Ile Met Gly Ile Gly Pro Val Pro Ala Ile Ser Gly Ala Leu 
    290                 295                 300                 


Lys Lys Ala Gly Leu Ser Leu Lys Asp Met Asp Leu Val Glu Val Asn 
305                 310                 315                 320 


Glu Ala Phe Ala Pro Gln Tyr Leu Ala Val Glu Arg Ser Leu Asp Leu 
                325                 330                 335     


Asp Ile Ser Lys Thr Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His 
            340                 345                 350         


Pro Leu Gly Gly Ser Gly Ser Arg Ile Thr Ala His Leu Val His Glu 
        355                 360                 365             


Leu Arg Arg Arg Gly Gly Lys Tyr Ala Val Gly Ser Ala Cys Ile Gly 
    370                 375                 380                 


Gly Gly Gln Gly Ile Ala Val Ile Ile Gln Ser Thr Ala 
385                 390                 395         


<210>  94
<211>  2383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACACA__Homo_sapiens__NP_942131

<400>  94

Met Trp Trp Ser Thr Leu Met Ser Ile Leu Arg Ala Arg Ser Phe Trp 
1               5                   10                  15      


Lys Trp Ile Ser Thr Gln Thr Val Arg Ile Ile Arg Ala Val Arg Ala 
            20                  25                  30          


His Phe Gly Gly Ile Met Asp Glu Pro Ser Pro Leu Ala Gln Pro Leu 
        35                  40                  45              


Glu Leu Asn Gln His Ser Arg Phe Ile Ile Gly Ser Val Ser Glu Asp 
    50                  55                  60                  


Asn Ser Glu Asp Glu Ile Ser Asn Leu Val Lys Leu Asp Leu Leu Glu 
65                  70                  75                  80  


Glu Lys Glu Gly Ser Leu Ser Pro Ala Ser Val Gly Ser Asp Thr Leu 
                85                  90                  95      


Ser Asp Leu Gly Ile Ser Ser Leu Gln Asp Gly Leu Ala Leu His Ile 
            100                 105                 110         


Arg Ser Ser Met Ser Gly Leu His Leu Val Lys Gln Gly Arg Asp Arg 
        115                 120                 125             


Lys Lys Ile Asp Ser Gln Arg Asp Phe Thr Val Ala Ser Pro Ala Glu 
    130                 135                 140                 


Phe Val Thr Arg Phe Gly Gly Asn Lys Val Ile Glu Lys Val Leu Ile 
145                 150                 155                 160 


Ala Asn Asn Gly Ile Ala Ala Val Lys Cys Met Arg Ser Ile Arg Arg 
                165                 170                 175     


Trp Ser Tyr Glu Met Phe Arg Asn Glu Arg Ala Ile Arg Phe Val Val 
            180                 185                 190         


Met Val Thr Pro Glu Asp Leu Lys Ala Asn Ala Glu Tyr Ile Lys Met 
        195                 200                 205             


Ala Asp His Tyr Val Pro Val Pro Gly Gly Pro Asn Asn Asn Asn Tyr 
    210                 215                 220                 


Ala Asn Val Glu Leu Ile Leu Asp Ile Ala Lys Arg Ile Pro Val Gln 
225                 230                 235                 240 


Ala Val Trp Ala Gly Trp Gly His Ala Ser Glu Asn Pro Lys Leu Pro 
                245                 250                 255     


Glu Leu Leu Leu Lys Asn Gly Ile Ala Phe Met Gly Pro Pro Ser Gln 
            260                 265                 270         


Ala Met Trp Ala Leu Gly Asp Lys Ile Ala Ser Ser Ile Val Ala Gln 
        275                 280                 285             


Thr Ala Gly Ile Pro Thr Leu Pro Trp Ser Gly Ser Gly Leu Arg Val 
    290                 295                 300                 


Asp Trp Gln Glu Asn Asp Phe Ser Lys Arg Ile Leu Asn Val Pro Gln 
305                 310                 315                 320 


Glu Leu Tyr Glu Lys Gly Tyr Val Lys Asp Val Asp Asp Gly Leu Gln 
                325                 330                 335     


Ala Ala Glu Glu Val Gly Tyr Pro Val Met Ile Lys Ala Ser Glu Gly 
            340                 345                 350         


Gly Gly Gly Lys Gly Ile Arg Lys Val Asn Asn Ala Asp Asp Phe Pro 
        355                 360                 365             


Asn Leu Phe Arg Gln Val Gln Ala Glu Val Pro Gly Ser Pro Ile Phe 
    370                 375                 380                 


Val Met Arg Leu Ala Lys Gln Ser Arg His Leu Glu Val Gln Ile Leu 
385                 390                 395                 400 


Ala Asp Gln Tyr Gly Asn Ala Ile Ser Leu Phe Gly Arg Asp Cys Ser 
                405                 410                 415     


Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Thr Ile 
            420                 425                 430         


Ala Thr Pro Ala Val Phe Glu His Met Glu Gln Cys Ala Val Lys Leu 
        435                 440                 445             


Ala Lys Met Val Gly Tyr Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr 
    450                 455                 460                 


Ser Gln Asp Gly Ser Phe Tyr Phe Leu Glu Leu Asn Pro Arg Leu Gln 
465                 470                 475                 480 


Val Glu His Pro Cys Thr Glu Met Val Ala Asp Val Asn Leu Pro Ala 
                485                 490                 495     


Ala Gln Leu Gln Ile Ala Met Gly Ile Pro Leu Tyr Arg Ile Lys Asp 
            500                 505                 510         


Ile Arg Met Met Tyr Gly Val Ser Pro Trp Gly Asp Ser Pro Ile Asp 
        515                 520                 525             


Phe Glu Asp Ser Ala His Val Pro Cys Pro Arg Gly His Val Ile Ala 
    530                 535                 540                 


Ala Arg Ile Thr Ser Glu Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser 
545                 550                 555                 560 


Gly Thr Val Gln Glu Leu Asn Phe Arg Ser Asn Lys Asn Val Trp Gly 
                565                 570                 575     


Tyr Phe Ser Val Ala Ala Ala Gly Gly Leu His Glu Phe Ala Asp Ser 
            580                 585                 590         


Gln Phe Gly His Cys Phe Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile 
        595                 600                 605             


Ser Asn Met Val Val Ala Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe 
    610                 615                 620                 


Arg Thr Thr Val Glu Tyr Leu Ile Lys Leu Leu Glu Thr Glu Ser Phe 
625                 630                 635                 640 


Gln Met Asn Arg Ile Asp Thr Gly Trp Leu Asp Arg Leu Ile Ala Glu 
                645                 650                 655     


Lys Val Gln Ala Glu Arg Pro Asp Thr Met Leu Gly Val Val Cys Gly 
            660                 665                 670         


Ala Leu His Val Ala Asp Val Ser Leu Arg Asn Ser Val Ser Asn Phe 
        675                 680                 685             


Leu His Ser Leu Glu Arg Gly Gln Val Leu Pro Ala His Thr Leu Leu 
    690                 695                 700                 


Asn Thr Val Asp Val Glu Leu Ile Tyr Glu Gly Val Lys Tyr Val Leu 
705                 710                 715                 720 


Lys Val Thr Arg Gln Ser Pro Asn Ser Tyr Val Val Ile Met Asn Gly 
                725                 730                 735     


Ser Cys Val Glu Val Asp Val His Arg Leu Ser Asp Gly Gly Leu Leu 
            740                 745                 750         


Leu Ser Tyr Asp Gly Ser Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val 
        755                 760                 765             


Asp Arg Tyr Arg Ile Thr Ile Gly Asn Lys Thr Cys Val Phe Glu Lys 
    770                 775                 780                 


Glu Asn Asp Pro Ser Val Met Arg Ser Pro Ser Ala Gly Lys Leu Ile 
785                 790                 795                 800 


Gln Tyr Ile Val Glu Asp Gly Gly His Val Phe Ala Gly Gln Cys Tyr 
                805                 810                 815     


Ala Glu Ile Glu Val Met Lys Met Val Met Thr Leu Thr Ala Val Glu 
            820                 825                 830         


Ser Gly Cys Ile His Tyr Val Lys Arg Pro Gly Ala Ala Leu Asp Pro 
        835                 840                 845             


Gly Cys Val Leu Ala Lys Met Gln Leu Asp Asn Pro Ser Lys Val Gln 
    850                 855                 860                 


Gln Ala Glu Leu His Thr Gly Ser Leu Pro Arg Ile Gln Ser Thr Ala 
865                 870                 875                 880 


Leu Arg Gly Glu Lys Leu His Arg Val Phe His Tyr Val Leu Asp Asn 
                885                 890                 895     


Leu Val Asn Val Met Asn Gly Tyr Cys Leu Pro Asp Pro Phe Phe Ser 
            900                 905                 910         


Ser Lys Val Lys Asp Trp Val Glu Arg Leu Met Lys Thr Leu Arg Asp 
        915                 920                 925             


Pro Ser Leu Pro Leu Leu Glu Leu Gln Asp Ile Met Thr Ser Val Ser 
    930                 935                 940                 


Gly Arg Ile Pro Pro Asn Val Glu Lys Ser Ile Lys Lys Glu Met Ala 
945                 950                 955                 960 


Gln Tyr Ala Ser Asn Ile Thr Ser Val Leu Cys Gln Phe Pro Ser Gln 
                965                 970                 975     


Gln Ile Ala Asn Ile Leu Asp Ser His Ala Ala Thr Leu Asn Arg Lys 
            980                 985                 990         


Ser Glu Arg Glu Val Phe Phe Met  Asn Thr Gln Ser Ile  Val Gln Leu 
        995                 1000                 1005             


Val Gln  Arg Tyr Arg Ser Gly  Ile Arg Gly His Met  Lys Ala Val 
    1010                 1015                 1020             


Val Met  Asp Leu Leu Arg Gln  Tyr Leu Arg Val Glu  Thr Gln Phe 
    1025                 1030                 1035             


Gln Asn  Gly His Tyr Asp Lys  Cys Val Phe Ala Leu  Arg Glu Glu 
    1040                 1045                 1050             


Asn Lys  Ser Asp Met Asn Thr  Val Leu Asn Tyr Ile  Phe Ser His 
    1055                 1060                 1065             


Ala Gln  Val Thr Lys Lys Asn  Leu Leu Val Thr Met  Leu Ile Asp 
    1070                 1075                 1080             


Gln Leu  Cys Gly Arg Asp Pro  Thr Leu Thr Asp Glu  Leu Leu Asn 
    1085                 1090                 1095             


Ile Leu  Thr Glu Leu Thr Gln  Leu Ser Lys Thr Thr  Asn Ala Lys 
    1100                 1105                 1110             


Val Ala  Leu Arg Ala Arg Gln  Val Leu Ile Ala Ser  His Leu Pro 
    1115                 1120                 1125             


Ser Tyr  Glu Leu Arg His Asn  Gln Val Glu Ser Ile  Phe Leu Ser 
    1130                 1135                 1140             


Ala Ile  Asp Met Tyr Gly His  Gln Phe Cys Ile Glu  Asn Leu Gln 
    1145                 1150                 1155             


Lys Leu  Ile Leu Ser Glu Thr  Ser Ile Phe Asp Val  Leu Pro Asn 
    1160                 1165                 1170             


Phe Phe  Tyr His Ser Asn Gln  Val Val Arg Met Ala  Ala Leu Glu 
    1175                 1180                 1185             


Val Tyr  Val Arg Arg Ala Tyr  Ile Ala Tyr Glu Leu  Asn Ser Val 
    1190                 1195                 1200             


Gln His  Arg Gln Leu Lys Asp  Asn Thr Cys Val Val  Glu Phe Gln 
    1205                 1210                 1215             


Phe Met  Leu Pro Thr Ser His  Pro Asn Arg Gly Asn  Ile Pro Thr 
    1220                 1225                 1230             


Leu Asn  Arg Met Ser Phe Ser  Ser Asn Leu Asn His  Tyr Gly Met 
    1235                 1240                 1245             


Thr His  Val Ala Ser Val Ser  Asp Val Leu Leu Asp  Asn Ser Phe 
    1250                 1255                 1260             


Thr Pro  Pro Cys Gln Arg Met  Gly Gly Met Val Ser  Phe Arg Thr 
    1265                 1270                 1275             


Phe Glu  Asp Phe Val Arg Ile  Phe Asp Glu Val Met  Gly Cys Phe 
    1280                 1285                 1290             


Ser Asp  Ser Pro Pro Gln Ser  Pro Thr Phe Pro Glu  Ala Gly His 
    1295                 1300                 1305             


Thr Ser  Leu Tyr Asp Glu Asp  Lys Val Pro Arg Asp  Glu Pro Ile 
    1310                 1315                 1320             


His Ile  Leu Asn Val Ala Ile  Lys Thr Asp Cys Asp  Ile Glu Asp 
    1325                 1330                 1335             


Asp Arg  Leu Ala Ala Met Phe  Arg Glu Phe Thr Gln  Gln Asn Lys 
    1340                 1345                 1350             


Ala Thr  Leu Val Asp His Gly  Ile Arg Arg Leu Thr  Phe Leu Val 
    1355                 1360                 1365             


Ala Gln  Lys Asp Phe Arg Lys  Gln Val Asn Tyr Glu  Val Asp Arg 
    1370                 1375                 1380             


Arg Phe  His Arg Glu Phe Pro  Lys Phe Phe Thr Phe  Arg Ala Arg 
    1385                 1390                 1395             


Asp Lys  Phe Glu Glu Asp Arg  Ile Tyr Arg His Leu  Glu Pro Ala 
    1400                 1405                 1410             


Leu Ala  Phe Gln Leu Glu Leu  Asn Arg Met Arg Asn  Phe Asp Leu 
    1415                 1420                 1425             


Thr Ala  Ile Pro Cys Ala Asn  His Lys Met His Leu  Tyr Leu Gly 
    1430                 1435                 1440             


Ala Ala  Lys Val Glu Val Gly  Thr Glu Val Thr Asp  Tyr Arg Phe 
    1445                 1450                 1455             


Phe Val  Arg Ala Ile Ile Arg  His Ser Asp Leu Val  Thr Lys Glu 
    1460                 1465                 1470             


Ala Ser  Phe Glu Tyr Leu Gln  Asn Glu Gly Glu Arg  Leu Leu Leu 
    1475                 1480                 1485             


Glu Ala  Met Asp Glu Leu Glu  Val Ala Phe Asn Asn  Thr Asn Val 
    1490                 1495                 1500             


Arg Thr  Asp Cys Asn His Ile  Phe Leu Asn Phe Val  Pro Thr Val 
    1505                 1510                 1515             


Ile Met  Asp Pro Ser Lys Ile  Glu Glu Ser Val Arg  Ser Met Val 
    1520                 1525                 1530             


Met Arg  Tyr Gly Ser Arg Leu  Trp Lys Leu Arg Val  Leu Gln Ala 
    1535                 1540                 1545             


Glu Leu  Lys Ile Asn Ile Arg  Leu Thr Pro Thr Gly  Lys Ala Ile 
    1550                 1555                 1560             


Pro Ile  Arg Leu Phe Leu Thr  Asn Glu Ser Gly Tyr  Tyr Leu Asp 
    1565                 1570                 1575             


Ile Ser  Leu Tyr Lys Glu Val  Thr Asp Ser Arg Thr  Ala Gln Ile 
    1580                 1585                 1590             


Met Phe  Gln Ala Tyr Gly Asp  Lys Gln Gly Pro Leu  His Gly Met 
    1595                 1600                 1605             


Leu Ile  Asn Thr Pro Tyr Val  Thr Lys Asp Leu Leu  Gln Ser Lys 
    1610                 1615                 1620             


Arg Phe  Gln Ala Gln Ser Leu  Gly Thr Thr Tyr Ile  Tyr Asp Ile 
    1625                 1630                 1635             


Pro Glu  Met Phe Arg Gln Ser  Leu Ile Lys Leu Trp  Glu Ser Met 
    1640                 1645                 1650             


Ser Thr  Gln Ala Phe Leu Pro  Ser Pro Pro Leu Pro  Ser Asp Met 
    1655                 1660                 1665             


Leu Thr  Tyr Thr Glu Leu Val  Leu Asp Asp Gln Gly  Gln Leu Val 
    1670                 1675                 1680             


His Met  Asn Arg Leu Pro Gly  Gly Asn Glu Ile Gly  Met Val Ala 
    1685                 1690                 1695             


Trp Lys  Met Thr Phe Lys Ser  Pro Glu Tyr Pro Glu  Gly Arg Asp 
    1700                 1705                 1710             


Ile Ile  Val Ile Gly Asn Asp  Ile Thr Tyr Arg Ile  Gly Ser Phe 
    1715                 1720                 1725             


Gly Pro  Gln Glu Asp Leu Leu  Phe Leu Arg Ala Ser  Glu Leu Ala 
    1730                 1735                 1740             


Arg Ala  Glu Gly Ile Pro Arg  Ile Tyr Val Ser Ala  Asn Ser Gly 
    1745                 1750                 1755             


Ala Arg  Ile Gly Leu Ala Glu  Glu Ile Arg His Met  Phe His Val 
    1760                 1765                 1770             


Ala Trp  Val Asp Pro Glu Asp  Pro Tyr Lys Gly Tyr  Arg Tyr Leu 
    1775                 1780                 1785             


Tyr Leu  Thr Pro Gln Asp Tyr  Lys Arg Val Ser Ala  Leu Asn Ser 
    1790                 1795                 1800             


Val His  Cys Glu His Val Glu  Asp Glu Gly Glu Ser  Arg Tyr Lys 
    1805                 1810                 1815             


Ile Thr  Asp Ile Ile Gly Lys  Glu Glu Gly Ile Gly  Pro Glu Asn 
    1820                 1825                 1830             


Leu Arg  Gly Ser Gly Met Ile  Ala Gly Glu Ser Ser  Leu Ala Tyr 
    1835                 1840                 1845             


Asn Glu  Ile Ile Thr Ile Ser  Leu Val Thr Cys Arg  Ala Ile Gly 
    1850                 1855                 1860             


Ile Gly  Ala Tyr Leu Val Arg  Leu Gly Gln Arg Thr  Ile Gln Val 
    1865                 1870                 1875             


Glu Asn  Ser His Leu Ile Leu  Thr Gly Ala Gly Ala  Leu Asn Lys 
    1880                 1885                 1890             


Val Leu  Gly Arg Glu Val Tyr  Thr Ser Asn Asn Gln  Leu Gly Gly 
    1895                 1900                 1905             


Ile Gln  Ile Met His Asn Asn  Gly Val Thr His Cys  Thr Val Cys 
    1910                 1915                 1920             


Asp Asp  Phe Glu Gly Val Phe  Thr Val Leu His Trp  Leu Ser Tyr 
    1925                 1930                 1935             


Met Pro  Lys Ser Val His Ser  Ser Val Pro Leu Leu  Asn Ser Lys 
    1940                 1945                 1950             


Asp Pro  Ile Asp Arg Ile Ile  Glu Phe Val Pro Thr  Lys Thr Pro 
    1955                 1960                 1965             


Tyr Asp  Pro Arg Trp Met Leu  Ala Gly Arg Pro His  Pro Thr Gln 
    1970                 1975                 1980             


Lys Gly  Gln Trp Leu Ser Gly  Phe Phe Asp Tyr Gly  Ser Phe Ser 
    1985                 1990                 1995             


Glu Ile  Met Gln Pro Trp Ala  Gln Thr Val Val Val  Gly Arg Ala 
    2000                 2005                 2010             


Arg Leu  Gly Gly Ile Pro Val  Gly Val Val Ala Val  Glu Thr Arg 
    2015                 2020                 2025             


Thr Val  Glu Leu Ser Ile Pro  Ala Asp Pro Ala Asn  Leu Asp Ser 
    2030                 2035                 2040             


Glu Ala  Lys Ile Ile Gln Gln  Ala Gly Gln Val Trp  Phe Pro Asp 
    2045                 2050                 2055             


Ser Ala  Phe Lys Thr Tyr Gln  Ala Ile Lys Asp Phe  Asn Arg Glu 
    2060                 2065                 2070             


Gly Leu  Pro Leu Met Val Phe  Ala Asn Trp Arg Gly  Phe Ser Gly 
    2075                 2080                 2085             


Gly Met  Lys Asp Met Tyr Asp  Gln Val Leu Lys Phe  Gly Ala Tyr 
    2090                 2095                 2100             


Ile Val  Asp Gly Leu Arg Glu  Cys Cys Gln Pro Val  Leu Val Tyr 
    2105                 2110                 2115             


Ile Pro  Pro Gln Ala Glu Leu  Arg Gly Gly Ser Trp  Val Val Ile 
    2120                 2125                 2130             


Asp Ser  Ser Ile Asn Pro Arg  His Met Glu Met Tyr  Ala Asp Arg 
    2135                 2140                 2145             


Glu Ser  Arg Gly Ser Val Leu  Glu Pro Glu Gly Thr  Val Glu Ile 
    2150                 2155                 2160             


Lys Phe  Arg Arg Lys Asp Leu  Val Lys Thr Met Arg  Arg Val Asp 
    2165                 2170                 2175             


Pro Val  Tyr Ile His Leu Ala  Glu Arg Leu Gly Thr  Pro Glu Leu 
    2180                 2185                 2190             


Ser Thr  Ala Glu Arg Lys Glu  Leu Glu Asn Lys Leu  Lys Glu Arg 
    2195                 2200                 2205             


Glu Glu  Phe Leu Ile Pro Ile  Tyr His Gln Val Ala  Val Gln Phe 
    2210                 2215                 2220             


Ala Asp  Leu His Asp Thr Pro  Gly Arg Met Gln Glu  Lys Gly Val 
    2225                 2230                 2235             


Ile Ser  Asp Ile Leu Asp Trp  Lys Thr Ser Arg Thr  Phe Phe Tyr 
    2240                 2245                 2250             


Trp Arg  Leu Arg Arg Leu Leu  Leu Glu Asp Leu Val  Lys Lys Lys 
    2255                 2260                 2265             


Ile His  Asn Ala Asn Pro Glu  Leu Thr Asp Gly Gln  Ile Gln Ala 
    2270                 2275                 2280             


Met Leu  Arg Arg Trp Phe Val  Glu Val Glu Gly Thr  Val Lys Ala 
    2285                 2290                 2295             


Tyr Val  Trp Asp Asn Asn Lys  Asp Leu Ala Glu Trp  Leu Glu Lys 
    2300                 2305                 2310             


Gln Leu  Thr Glu Glu Asp Gly  Val His Ser Val Ile  Glu Glu Asn 
    2315                 2320                 2325             


Ile Lys  Cys Ile Ser Arg Asp  Tyr Val Leu Lys Gln  Ile Arg Ser 
    2330                 2335                 2340             


Leu Val  Gln Ala Asn Pro Glu  Val Ala Met Asp Ser  Ile Ile His 
    2345                 2350                 2355             


Met Thr  Gln His Ile Ser Pro  Thr Gln Arg Ala Glu  Val Ile Arg 
    2360                 2365                 2370             


Ile Leu  Ser Thr Met Asp Ser  Pro Ser Thr 
    2375                 2380             


<210>  95
<211>  2458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACACB__Homo_sapiens__XP_011536564

<400>  95

Met Val Leu Leu Leu Cys Leu Ser Cys Leu Ile Phe Ser Cys Leu Thr 
1               5                   10                  15      


Phe Ser Trp Leu Lys Ile Trp Gly Lys Met Thr Asp Ser Lys Pro Ile 
            20                  25                  30          


Thr Lys Ser Lys Ser Glu Ala Asn Leu Ile Pro Ser Gln Glu Pro Phe 
        35                  40                  45              


Pro Ala Ser Asp Asn Ser Gly Glu Thr Pro Gln Arg Asn Gly Glu Gly 
    50                  55                  60                  


His Thr Leu Pro Lys Thr Pro Ser Gln Ala Glu Pro Ala Ser His Lys 
65                  70                  75                  80  


Gly Pro Lys Asp Ala Gly Arg Arg Arg Asn Ser Leu Pro Pro Ser His 
                85                  90                  95      


Gln Lys Pro Pro Arg Asn Pro Leu Ser Ser Ser Asp Ala Ala Pro Ser 
            100                 105                 110         


Pro Glu Leu Gln Ala Asn Gly Thr Gly Thr Gln Gly Leu Glu Ala Thr 
        115                 120                 125             


Asp Thr Asn Gly Leu Ser Ser Ser Ala Arg Pro Gln Gly Gln Gln Ala 
    130                 135                 140                 


Gly Ser Pro Ser Lys Glu Asp Lys Lys Gln Ala Asn Ile Lys Arg Gln 
145                 150                 155                 160 


Leu Met Thr Asn Phe Ile Leu Gly Ser Phe Asp Asp Tyr Ser Ser Asp 
                165                 170                 175     


Glu Asp Ser Val Ala Gly Ser Ser Arg Glu Ser Thr Arg Lys Gly Ser 
            180                 185                 190         


Arg Ala Ser Leu Gly Ala Leu Ser Leu Glu Ala Tyr Leu Thr Thr Gly 
        195                 200                 205             


Glu Ala Glu Thr Arg Val Pro Thr Met Arg Pro Ser Met Ser Gly Leu 
    210                 215                 220                 


His Leu Val Lys Arg Gly Arg Glu His Lys Lys Leu Asp Leu His Arg 
225                 230                 235                 240 


Asp Phe Thr Val Ala Ser Pro Ala Glu Phe Val Thr Arg Phe Gly Gly 
                245                 250                 255     


Asp Arg Val Ile Glu Lys Val Leu Ile Ala Asn Asn Gly Ile Ala Ala 
            260                 265                 270         


Val Lys Cys Met Arg Ser Ile Arg Arg Trp Ala Tyr Glu Met Phe Arg 
        275                 280                 285             


Asn Glu Arg Ala Ile Arg Phe Val Val Met Val Thr Pro Glu Asp Leu 
    290                 295                 300                 


Lys Ala Asn Ala Glu Tyr Ile Lys Met Ala Asp His Tyr Val Pro Val 
305                 310                 315                 320 


Pro Gly Gly Pro Asn Asn Asn Asn Tyr Ala Asn Val Glu Leu Ile Val 
                325                 330                 335     


Asp Ile Ala Lys Arg Ile Pro Val Gln Ala Val Trp Ala Gly Trp Gly 
            340                 345                 350         


His Ala Ser Glu Asn Pro Lys Leu Pro Glu Leu Leu Cys Lys Asn Gly 
        355                 360                 365             


Val Ala Phe Leu Gly Pro Pro Ser Glu Ala Met Trp Ala Leu Gly Asp 
    370                 375                 380                 


Lys Ile Ala Ser Thr Val Val Ala Gln Thr Leu Gln Val Pro Thr Leu 
385                 390                 395                 400 


Pro Trp Ser Gly Ser Gly Leu Thr Val Glu Trp Thr Glu Asp Asp Leu 
                405                 410                 415     


Gln Gln Gly Lys Arg Ile Ser Val Pro Glu Asp Val Tyr Asp Lys Gly 
            420                 425                 430         


Cys Val Lys Asp Val Asp Glu Gly Leu Glu Ala Ala Glu Arg Ile Gly 
        435                 440                 445             


Phe Pro Leu Met Ile Lys Ala Ser Glu Gly Gly Gly Gly Lys Gly Ile 
    450                 455                 460                 


Arg Lys Ala Glu Ser Ala Glu Asp Phe Pro Ile Leu Phe Arg Gln Val 
465                 470                 475                 480 


Gln Ser Glu Ile Pro Gly Ser Pro Ile Phe Leu Met Lys Leu Ala Gln 
                485                 490                 495     


His Ala Arg His Leu Glu Val Gln Ile Leu Ala Asp Gln Tyr Gly Asn 
            500                 505                 510         


Ala Val Ser Leu Phe Gly Arg Asp Cys Ser Ile Gln Arg Arg His Gln 
        515                 520                 525             


Lys Ile Val Glu Glu Ala Pro Ala Thr Ile Ala Pro Leu Ala Ile Phe 
    530                 535                 540                 


Glu Phe Met Glu Gln Cys Ala Ile Arg Leu Ala Lys Thr Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ala Gly Thr Val Glu Tyr Leu Tyr Ser Gln Asp Gly Ser Phe 
                565                 570                 575     


His Phe Leu Glu Leu Asn Pro Arg Leu Gln Val Glu His Pro Cys Thr 
            580                 585                 590         


Glu Met Ile Ala Asp Val Asn Leu Pro Ala Ala Gln Leu Gln Ile Ala 
        595                 600                 605             


Met Gly Val Pro Leu His Arg Leu Lys Asp Ile Arg Leu Leu Tyr Gly 
    610                 615                 620                 


Glu Ser Pro Trp Gly Val Thr Pro Ile Ser Phe Glu Thr Pro Ser Asn 
625                 630                 635                 640 


Pro Pro Leu Ala Arg Gly His Val Ile Ala Ala Arg Ile Thr Ser Glu 
                645                 650                 655     


Asn Pro Asp Glu Gly Phe Lys Pro Ser Ser Gly Thr Val Gln Glu Leu 
            660                 665                 670         


Asn Phe Arg Ser Ser Lys Asn Val Trp Gly Tyr Phe Ser Val Ala Ala 
        675                 680                 685             


Thr Gly Gly Leu His Glu Phe Ala Asp Ser Gln Phe Gly His Cys Phe 
    690                 695                 700                 


Ser Trp Gly Glu Asn Arg Glu Glu Ala Ile Ser Asn Met Val Val Ala 
705                 710                 715                 720 


Leu Lys Glu Leu Ser Ile Arg Gly Asp Phe Arg Thr Thr Val Glu Tyr 
                725                 730                 735     


Leu Ile Asn Leu Leu Glu Thr Glu Ser Phe Gln Asn Asn Asp Ile Asp 
            740                 745                 750         


Thr Gly Trp Leu Asp Tyr Leu Ile Ala Glu Lys Val Gln Ala Glu Lys 
        755                 760                 765             


Pro Asp Ile Met Leu Gly Val Val Cys Gly Ala Leu Asn Val Ala Asp 
    770                 775                 780                 


Ala Met Phe Arg Thr Cys Met Thr Asp Phe Leu His Ser Leu Glu Arg 
785                 790                 795                 800 


Gly Gln Val Leu Pro Ala Asp Ser Leu Leu Asn Leu Val Asp Val Glu 
                805                 810                 815     


Leu Ile Tyr Gly Gly Val Lys Tyr Ile Leu Lys Val Ala Arg Gln Ser 
            820                 825                 830         


Leu Thr Met Phe Val Leu Ile Met Asn Gly Cys His Ile Glu Ile Asp 
        835                 840                 845             


Ala His Arg Leu Asn Asp Gly Gly Leu Leu Leu Ser Tyr Asn Gly Asn 
    850                 855                 860                 


Ser Tyr Thr Thr Tyr Met Lys Glu Glu Val Asp Ser Tyr Arg Ile Thr 
865                 870                 875                 880 


Ile Gly Asn Lys Thr Cys Val Phe Glu Lys Glu Asn Asp Pro Thr Val 
                885                 890                 895     


Leu Arg Ser Pro Ser Ala Gly Lys Leu Thr Gln Tyr Thr Val Glu Asp 
            900                 905                 910         


Gly Gly His Val Glu Ala Gly Ser Ser Tyr Ala Glu Met Glu Val Met 
        915                 920                 925             


Lys Met Ile Met Thr Leu Asn Val Gln Glu Arg Gly Arg Val Lys Tyr 
    930                 935                 940                 


Ile Lys Arg Pro Gly Ala Val Leu Glu Ala Gly Cys Val Val Ala Arg 
945                 950                 955                 960 


Leu Glu Leu Asp Asp Pro Ser Lys Val His Pro Ala Glu Pro Phe Thr 
                965                 970                 975     


Gly Glu Leu Pro Ala Gln Gln Thr Leu Pro Ile Leu Gly Glu Lys Leu 
            980                 985                 990         


His Gln Val Phe His Ser Val Leu  Glu Asn Leu Thr Asn  Val Met Ser 
        995                 1000                 1005             


Gly Phe  Cys Leu Pro Glu Pro  Val Phe Ser Ile Lys  Leu Lys Glu 
    1010                 1015                 1020             


Trp Val  Gln Lys Leu Met Met  Thr Leu Arg His Pro  Ser Leu Pro 
    1025                 1030                 1035             


Leu Leu  Glu Leu Gln Glu Ile  Met Thr Ser Val Ala  Gly Arg Ile 
    1040                 1045                 1050             


Pro Ala  Pro Val Glu Lys Ser  Val Arg Arg Val Met  Ala Gln Tyr 
    1055                 1060                 1065             


Ala Ser  Asn Ile Thr Ser Val  Leu Cys Gln Phe Pro  Ser Gln Gln 
    1070                 1075                 1080             


Ile Ala  Thr Ile Leu Asp Cys  His Ala Ala Thr Leu  Gln Arg Lys 
    1085                 1090                 1095             


Ala Asp  Arg Glu Val Phe Phe  Ile Asn Thr Gln Ser  Ile Val Gln 
    1100                 1105                 1110             


Leu Val  Gln Arg Tyr Arg Ser  Gly Ile Arg Gly Tyr  Met Lys Thr 
    1115                 1120                 1125             


Val Val  Leu Asp Leu Leu Arg  Arg Tyr Leu Arg Val  Glu His His 
    1130                 1135                 1140             


Phe Gln  Gln Ala His Tyr Asp  Lys Cys Val Ile Asn  Leu Arg Glu 
    1145                 1150                 1155             


Gln Phe  Lys Pro Asp Met Ser  Gln Val Leu Asp Cys  Ile Phe Ser 
    1160                 1165                 1170             


His Ala  Gln Val Ala Lys Lys  Asn Gln Leu Val Ile  Met Leu Ile 
    1175                 1180                 1185             


Asp Glu  Leu Cys Gly Pro Asp  Pro Ser Leu Ser Asp  Glu Leu Ile 
    1190                 1195                 1200             


Ser Ile  Leu Asn Glu Leu Thr  Gln Leu Ser Lys Ser  Glu His Cys 
    1205                 1210                 1215             


Lys Val  Ala Leu Arg Ala Arg  Gln Ile Leu Ile Ala  Ser His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Glu Leu Arg His  Asn Gln Val Glu Ser  Ile Phe Leu 
    1235                 1240                 1245             


Ser Ala  Ile Asp Met Tyr Gly  His Gln Phe Cys Pro  Glu Asn Leu 
    1250                 1255                 1260             


Lys Lys  Leu Ile Leu Ser Glu  Thr Thr Ile Phe Asp  Val Leu Pro 
    1265                 1270                 1275             


Thr Phe  Phe Tyr His Ala Asn  Lys Val Val Cys Met  Ala Ser Leu 
    1280                 1285                 1290             


Glu Val  Tyr Val Arg Arg Gly  Tyr Ile Ala Tyr Glu  Leu Asn Ser 
    1295                 1300                 1305             


Leu Gln  His Arg Gln Leu Pro  Asp Gly Thr Cys Val  Val Glu Phe 
    1310                 1315                 1320             


Gln Phe  Met Leu Pro Ser Ser  His Pro Asn Arg Met  Thr Val Pro 
    1325                 1330                 1335             


Ile Ser  Ile Thr Asn Pro Asp  Leu Leu Arg His Ser  Thr Glu Leu 
    1340                 1345                 1350             


Phe Met  Asp Ser Gly Phe Ser  Pro Leu Cys Gln Arg  Met Gly Ala 
    1355                 1360                 1365             


Met Val  Ala Phe Arg Arg Phe  Glu Asp Phe Thr Arg  Asn Phe Asp 
    1370                 1375                 1380             


Glu Val  Ile Ser Cys Phe Ala  Asn Val Pro Lys Asp  Thr Pro Leu 
    1385                 1390                 1395             


Phe Ser  Glu Ala Arg Thr Ser  Leu Tyr Ser Glu Asp  Asp Cys Lys 
    1400                 1405                 1410             


Ser Leu  Arg Glu Glu Pro Ile  His Ile Leu Asn Val  Ser Ile Gln 
    1415                 1420                 1425             


Cys Ala  Asp His Leu Glu Asp  Glu Ala Leu Val Pro  Ile Leu Arg 
    1430                 1435                 1440             


Thr Phe  Val Gln Ser Lys Lys  Asn Ile Leu Val Asp  Tyr Gly Leu 
    1445                 1450                 1455             


Arg Arg  Ile Thr Phe Leu Ile  Ala Gln Glu Lys Glu  Phe Pro Lys 
    1460                 1465                 1470             


Phe Phe  Thr Phe Arg Ala Arg  Asp Glu Phe Ala Glu  Asp Arg Ile 
    1475                 1480                 1485             


Tyr Arg  His Leu Glu Pro Ala  Leu Ala Phe Gln Leu  Glu Leu Asn 
    1490                 1495                 1500             


Arg Met  Arg Asn Phe Asp Leu  Thr Ala Val Pro Cys  Ala Asn His 
    1505                 1510                 1515             


Lys Met  His Leu Tyr Leu Gly  Ala Ala Lys Val Lys  Glu Gly Val 
    1520                 1525                 1530             


Glu Val  Thr Asp His Arg Phe  Phe Ile Arg Ala Ile  Ile Arg His 
    1535                 1540                 1545             


Ser Asp  Leu Ile Thr Lys Glu  Ala Ser Phe Glu Tyr  Leu Gln Asn 
    1550                 1555                 1560             


Glu Gly  Glu Arg Leu Leu Leu  Glu Ala Met Asp Glu  Leu Glu Val 
    1565                 1570                 1575             


Ala Phe  Asn Asn Thr Ser Val  Arg Thr Asp Cys Asn  His Ile Phe 
    1580                 1585                 1590             


Leu Asn  Phe Val Pro Thr Val  Ile Met Asp Pro Phe  Lys Ile Glu 
    1595                 1600                 1605             


Glu Ser  Val Arg Tyr Met Val  Met Arg Tyr Gly Ser  Arg Leu Trp 
    1610                 1615                 1620             


Lys Leu  Arg Val Leu Gln Ala  Glu Val Lys Ile Asn  Ile Arg Gln 
    1625                 1630                 1635             


Thr Thr  Thr Gly Ser Ala Val  Pro Ile Arg Leu Phe  Ile Thr Asn 
    1640                 1645                 1650             


Glu Ser  Gly Tyr Tyr Leu Asp  Ile Ser Leu Tyr Lys  Glu Val Thr 
    1655                 1660                 1665             


Asp Ser  Arg Ser Gly Asn Ile  Met Phe His Ser Phe  Gly Asn Lys 
    1670                 1675                 1680             


Gln Gly  Pro Gln His Gly Met  Leu Ile Asn Thr Pro  Tyr Val Thr 
    1685                 1690                 1695             


Lys Asp  Leu Leu Gln Ala Lys  Arg Phe Gln Ala Gln  Thr Leu Gly 
    1700                 1705                 1710             


Thr Thr  Tyr Ile Tyr Asp Phe  Pro Glu Met Phe Arg  Gln Ala Leu 
    1715                 1720                 1725             


Phe Lys  Leu Trp Gly Ser Pro  Asp Lys Tyr Pro Lys  Asp Ile Leu 
    1730                 1735                 1740             


Thr Tyr  Thr Glu Leu Val Leu  Asp Ser Gln Gly Gln  Leu Val Glu 
    1745                 1750                 1755             


Met Asn  Arg Leu Pro Gly Gly  Asn Glu Val Gly Met  Val Ala Phe 
    1760                 1765                 1770             


Lys Met  Arg Phe Lys Thr Gln  Glu Tyr Pro Glu Gly  Arg Asp Val 
    1775                 1780                 1785             


Ile Val  Ile Gly Asn Asp Ile  Thr Phe Arg Ile Gly  Ser Phe Gly 
    1790                 1795                 1800             


Pro Gly  Glu Asp Leu Leu Tyr  Leu Arg Ala Ser Glu  Met Ala Arg 
    1805                 1810                 1815             


Ala Glu  Gly Ile Pro Lys Ile  Tyr Val Ala Ala Asn  Ser Gly Ala 
    1820                 1825                 1830             


Arg Ile  Gly Met Ala Glu Glu  Ile Lys His Met Phe  His Val Ala 
    1835                 1840                 1845             


Trp Val  Asp Pro Glu Asp Pro  His Lys Gly Phe Lys  Tyr Leu Tyr 
    1850                 1855                 1860             


Leu Thr  Pro Gln Asp Tyr Thr  Arg Ile Ser Ser Leu  Asn Ser Val 
    1865                 1870                 1875             


His Cys  Lys His Ile Glu Glu  Gly Gly Glu Ser Arg  Tyr Met Ile 
    1880                 1885                 1890             


Thr Asp  Ile Ile Gly Lys Asp  Asp Gly Leu Gly Val  Glu Asn Leu 
    1895                 1900                 1905             


Arg Gly  Ser Gly Met Ile Ala  Gly Glu Ser Ser Leu  Ala Tyr Glu 
    1910                 1915                 1920             


Glu Ile  Val Thr Ile Ser Leu  Val Thr Cys Arg Ala  Ile Gly Ile 
    1925                 1930                 1935             


Gly Ala  Tyr Leu Val Arg Leu  Gly Gln Arg Val Ile  Gln Val Glu 
    1940                 1945                 1950             


Asn Ser  His Ile Ile Leu Thr  Gly Ala Ser Ala Leu  Asn Lys Val 
    1955                 1960                 1965             


Leu Gly  Arg Glu Val Tyr Thr  Ser Asn Asn Gln Leu  Gly Gly Val 
    1970                 1975                 1980             


Gln Ile  Met His Tyr Asn Gly  Val Ser His Ile Thr  Val Pro Asp 
    1985                 1990                 1995             


Asp Phe  Glu Gly Val Tyr Thr  Ile Leu Glu Trp Leu  Ser Tyr Met 
    2000                 2005                 2010             


Pro Lys  Asp Asn His Ser Pro  Val Pro Ile Ile Thr  Pro Thr Asp 
    2015                 2020                 2025             


Pro Ile  Asp Arg Glu Ile Glu  Phe Leu Pro Ser Arg  Ala Pro Tyr 
    2030                 2035                 2040             


Asp Pro  Arg Trp Met Leu Ala  Gly Arg Pro His Pro  Thr Leu Lys 
    2045                 2050                 2055             


Gly Thr  Trp Gln Ser Gly Phe  Phe Asp His Gly Ser  Phe Lys Glu 
    2060                 2065                 2070             


Ile Met  Ala Pro Trp Ala Gln  Thr Val Val Thr Gly  Arg Ala Arg 
    2075                 2080                 2085             


Leu Gly  Gly Ile Pro Val Gly  Val Ile Ala Val Glu  Thr Arg Thr 
    2090                 2095                 2100             


Val Glu  Val Ala Val Pro Ala  Asp Pro Ala Asn Leu  Asp Ser Glu 
    2105                 2110                 2115             


Ala Lys  Ile Ile Gln Gln Ala  Gly Gln Val Trp Phe  Pro Asp Ser 
    2120                 2125                 2130             


Ala Tyr  Lys Thr Ala Gln Ala  Val Lys Asp Phe Asn  Arg Glu Lys 
    2135                 2140                 2145             


Leu Pro  Leu Met Ile Phe Ala  Asn Trp Arg Gly Phe  Ser Gly Gly 
    2150                 2155                 2160             


Met Lys  Asp Met Tyr Asp Gln  Val Leu Lys Phe Gly  Ala Tyr Ile 
    2165                 2170                 2175             


Val Asp  Gly Leu Arg Gln Tyr  Lys Gln Pro Ile Leu  Ile Tyr Ile 
    2180                 2185                 2190             


Pro Pro  Tyr Ala Glu Leu Arg  Gly Gly Ser Trp Val  Val Ile Asp 
    2195                 2200                 2205             


Ala Thr  Ile Asn Pro Leu Cys  Ile Glu Met Tyr Ala  Asp Lys Glu 
    2210                 2215                 2220             


Ser Arg  Gly Gly Val Leu Glu  Pro Glu Gly Thr Val  Glu Ile Lys 
    2225                 2230                 2235             


Phe Arg  Lys Lys Asp Leu Ile  Lys Ser Met Arg Arg  Ile Asp Pro 
    2240                 2245                 2250             


Ala Tyr  Lys Lys Leu Met Glu  Gln Leu Gly Glu Pro  Asp Leu Ser 
    2255                 2260                 2265             


Asp Lys  Asp Arg Lys Asp Leu  Glu Gly Arg Leu Lys  Ala Arg Glu 
    2270                 2275                 2280             


Asp Leu  Leu Leu Pro Ile Tyr  His Gln Val Ala Val  Gln Phe Ala 
    2285                 2290                 2295             


Asp Phe  His Asp Thr Pro Gly  Arg Met Leu Glu Lys  Gly Val Ile 
    2300                 2305                 2310             


Ser Asp  Ile Leu Glu Trp Lys  Thr Ala Arg Thr Phe  Leu Tyr Trp 
    2315                 2320                 2325             


Arg Leu  Arg Arg Leu Leu Leu  Glu Asp Gln Val Lys  Gln Glu Ile 
    2330                 2335                 2340             


Leu Gln  Ala Ser Gly Glu Leu  Ser His Val His Ile  Gln Ser Met 
    2345                 2350                 2355             


Leu Arg  Arg Trp Phe Val Glu  Thr Glu Gly Ala Val  Lys Ala Tyr 
    2360                 2365                 2370             


Leu Trp  Asp Asn Asn Gln Val  Val Val Gln Trp Leu  Glu Gln His 
    2375                 2380                 2385             


Trp Gln  Ala Gly Asp Gly Pro  Arg Ser Thr Ile Arg  Glu Asn Ile 
    2390                 2395                 2400             


Thr Tyr  Leu Lys His Asp Ser  Val Leu Lys Thr Ile  Arg Gly Leu 
    2405                 2410                 2415             


Val Glu  Glu Asn Pro Glu Val  Ala Val Asp Cys Val  Ile Tyr Leu 
    2420                 2425                 2430             


Ser Gln  His Ile Ser Pro Ala  Glu Arg Ala Gln Val  Val His Leu 
    2435                 2440                 2445             


Leu Ser  Thr Met Asp Ser Pro  Ala Ser Thr 
    2450                 2455             


<210>  96
<211>  1090
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAD10__Homo_sapiens__NP_001130010

<400>  96

Met Cys Val Arg Ser Cys Phe Gln Ser Pro Arg Leu Gln Trp Val Trp 
1               5                   10                  15      


Arg Thr Ala Phe Leu Lys His Thr Gln Arg Arg His Gln Gly Ser His 
            20                  25                  30          


Arg Trp Thr His Leu Gly Gly Ser Thr Tyr Arg Ala Val Ile Phe Asp 
        35                  40                  45              


Met Gly Gly Val Leu Ile Pro Ser Pro Gly Arg Val Ala Ala Glu Trp 
    50                  55                  60                  


Glu Val Gln Asn Arg Ile Pro Ser Gly Thr Ile Leu Lys Ala Leu Met 
65                  70                  75                  80  


Glu Gly Gly Glu Asn Gly Pro Trp Met Arg Phe Met Arg Ala Glu Ile 
                85                  90                  95      


Thr Ala Glu Gly Phe Leu Arg Glu Phe Gly Arg Leu Cys Ser Glu Met 
            100                 105                 110         


Leu Lys Thr Ser Val Pro Val Asp Ser Phe Phe Ser Leu Leu Thr Ser 
        115                 120                 125             


Glu Arg Val Ala Lys Gln Phe Pro Val Met Thr Glu Ala Ile Thr Gln 
    130                 135                 140                 


Ile Arg Ala Lys Gly Leu Gln Thr Ala Val Leu Ser Asn Asn Phe Tyr 
145                 150                 155                 160 


Leu Pro Asn Gln Lys Ser Phe Leu Pro Leu Asp Arg Lys Gln Phe Asp 
                165                 170                 175     


Val Ile Val Glu Ser Cys Met Glu Gly Ile Cys Lys Pro Asp Pro Arg 
            180                 185                 190         


Ile Tyr Lys Leu Cys Leu Glu Gln Leu Gly Leu Gln Pro Ser Glu Ser 
        195                 200                 205             


Ile Phe Leu Asp Asp Leu Gly Thr Asn Leu Lys Glu Ala Ala Arg Leu 
    210                 215                 220                 


Gly Ile His Thr Ile Lys Arg Gln Gly Phe Ala Val Leu Pro Lys Leu 
225                 230                 235                 240 


Val Ser Asn Ser Trp Ala Gln Ala Ile Tyr Pro Pro Tyr Pro Pro Lys 
                245                 250                 255     


Val Val Arg Leu Gln Val Asn Asp Pro Glu Thr Ala Val Lys Glu Leu 
            260                 265                 270         


Glu Ala Leu Leu Gly Phe Thr Leu Arg Val Gly Val Pro Asn Thr Arg 
        275                 280                 285             


Pro Val Lys Lys Thr Met Glu Ile Pro Lys Asp Ser Leu Gln Lys Tyr 
    290                 295                 300                 


Leu Lys Asp Leu Leu Gly Ile Gln Thr Thr Gly Pro Leu Glu Leu Leu 
305                 310                 315                 320 


Gln Phe Asp His Gly Gln Ser Asn Pro Thr Tyr Tyr Ile Arg Leu Ala 
                325                 330                 335     


Asn Arg Asp Leu Val Leu Arg Lys Lys Pro Pro Gly Thr Leu Leu Pro 
            340                 345                 350         


Ser Ala His Ala Ile Glu Arg Glu Phe Arg Ile Met Lys Ala Leu Ala 
        355                 360                 365             


Asn Ala Gly Val Pro Val Pro Asn Val Leu Asp Leu Cys Glu Asp Ser 
    370                 375                 380                 


Ser Val Ile Gly Thr Pro Phe Tyr Val Met Glu Tyr Cys Pro Gly Leu 
385                 390                 395                 400 


Ile Tyr Lys Asp Pro Ser Leu Pro Gly Leu Glu Pro Ser His Arg Arg 
                405                 410                 415     


Ala Ile Tyr Thr Ala Met Asn Thr Val Leu Cys Lys Ile His Ser Val 
            420                 425                 430         


Asp Leu Gln Ala Val Gly Leu Glu Asp Tyr Gly Lys Gln Gly Asp Tyr 
        435                 440                 445             


Ile Pro Arg Gln Val Arg Thr Trp Val Lys Gln Tyr Arg Ala Ser Glu 
    450                 455                 460                 


Thr Ser Thr Ile Pro Ala Met Glu Arg Leu Ile Glu Trp Leu Pro Leu 
465                 470                 475                 480 


His Leu Pro Arg Gln Gln Arg Thr Thr Val Val His Gly Asp Phe Arg 
                485                 490                 495     


Leu Asp Asn Leu Val Phe His Pro Glu Glu Pro Glu Val Leu Ala Val 
            500                 505                 510         


Leu Asp Trp Glu Leu Ser Thr Leu Gly Asp Pro Leu Ala Asp Val Ala 
        515                 520                 525             


Tyr Ser Cys Leu Ala His Tyr Leu Pro Ser Ser Phe Pro Val Leu Arg 
    530                 535                 540                 


Gly Ile Asn Asp Cys Asp Leu Thr Gln Leu Gly Ile Pro Ala Ala Glu 
545                 550                 555                 560 


Glu Tyr Phe Arg Met Tyr Cys Leu Gln Met Gly Leu Pro Pro Thr Glu 
                565                 570                 575     


Asn Trp Asn Phe Tyr Met Ala Phe Ser Phe Phe Arg Val Ala Ala Ile 
            580                 585                 590         


Leu Gln Gly Val Tyr Lys Arg Ser Leu Thr Gly Gln Ala Ser Ser Thr 
        595                 600                 605             


Tyr Ala Glu Gln Thr Gly Lys Leu Thr Glu Phe Val Ser Asn Leu Ala 
    610                 615                 620                 


Trp Asp Phe Ala Val Lys Glu Gly Phe Arg Val Phe Lys Glu Met Pro 
625                 630                 635                 640 


Phe Thr Asn Pro Leu Thr Arg Ser Tyr His Thr Trp Ala Arg Pro Gln 
                645                 650                 655     


Ser Gln Trp Cys Pro Thr Gly Ser Arg Ser Tyr Ser Ser Val Pro Glu 
            660                 665                 670         


Ala Ser Pro Ala His Thr Ser Arg Gly Gly Leu Val Ile Ser Pro Glu 
        675                 680                 685             


Ser Leu Ser Pro Pro Val Arg Glu Leu Tyr His Arg Leu Lys His Phe 
    690                 695                 700                 


Met Glu Gln Arg Val Tyr Pro Ala Glu Pro Glu Leu Gln Ser His Gln 
705                 710                 715                 720 


Ala Ser Ala Ala Arg Trp Ser Pro Ser Pro Leu Ile Glu Asp Leu Lys 
                725                 730                 735     


Glu Lys Ala Lys Ala Glu Gly Leu Trp Asn Leu Phe Leu Pro Leu Glu 
            740                 745                 750         


Ala Asp Pro Glu Lys Lys Tyr Gly Ala Gly Leu Thr Asn Val Glu Tyr 
        755                 760                 765             


Ala His Leu Cys Glu Leu Met Gly Thr Ser Leu Tyr Ala Pro Glu Val 
    770                 775                 780                 


Cys Asn Cys Ser Ala Pro Asp Thr Gly Asn Met Glu Leu Leu Val Arg 
785                 790                 795                 800 


Tyr Gly Thr Glu Ala Gln Lys Ala Arg Trp Leu Ile Pro Leu Leu Glu 
                805                 810                 815     


Gly Lys Ala Arg Ser Cys Phe Ala Met Thr Glu Pro Gln Val Ala Ser 
            820                 825                 830         


Ser Asp Ala Thr Asn Ile Glu Ala Ser Ile Arg Glu Glu Asp Ser Phe 
        835                 840                 845             


Tyr Val Ile Asn Gly His Lys Trp Trp Ile Thr Gly Ile Leu Asp Pro 
    850                 855                 860                 


Arg Cys Gln Leu Cys Val Phe Met Gly Lys Thr Asp Pro His Ala Pro 
865                 870                 875                 880 


Arg His Arg Gln Gln Ser Val Leu Leu Val Pro Met Asp Thr Pro Gly 
                885                 890                 895     


Ile Lys Ile Ile Arg Pro Leu Thr Val Tyr Gly Leu Glu Asp Ala Pro 
            900                 905                 910         


Gly Gly His Gly Glu Val Arg Phe Glu His Val Arg Val Pro Lys Glu 
        915                 920                 925             


Asn Met Val Leu Gly Pro Gly Arg Gly Phe Glu Ile Ala Gln Gly Arg 
    930                 935                 940                 


Leu Gly Pro Gly Arg Ile His His Cys Met Arg Leu Ile Gly Phe Ser 
945                 950                 955                 960 


Glu Arg Ala Leu Ala Leu Met Lys Ala Arg Val Lys Ser Arg Leu Ala 
                965                 970                 975     


Phe Gly Lys Pro Leu Val Glu Gln Gly Thr Val Leu Ala Asp Ile Ala 
            980                 985                 990         


Gln Ser Arg Val Glu Ile Glu Gln  Ala Arg Leu Leu Val  Leu Arg Ala 
        995                 1000                 1005             


Ala His  Leu Met Asp Leu Ala  Gly Asn Lys Ala Ala  Ala Leu Asp 
    1010                 1015                 1020             


Ile Ala  Met Ile Lys Met Val  Ala Pro Ser Met Ala  Ser Arg Val 
    1025                 1030                 1035             


Ile Asp  Arg Ala Ile Gln Ala  Phe Gly Ala Ala Gly  Leu Ser Ser 
    1040                 1045                 1050             


Asp Tyr  Pro Leu Ala Gln Phe  Phe Thr Trp Ala Arg  Ala Leu Arg 
    1055                 1060                 1065             


Phe Ala  Asp Gly Pro Asp Glu  Val His Arg Ala Thr  Val Ala Lys 
    1070                 1075                 1080             


Leu Glu  Leu Lys His Arg Ile  
    1085                 1090 


<210>  97
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAD8__Homo_sapiens__NP_055199

<400>  97

Met Leu Trp Ser Gly Cys Arg Arg Phe Gly Ala Arg Leu Gly Cys Leu 
1               5                   10                  15      


Pro Gly Gly Leu Arg Val Leu Val Gln Thr Gly His Arg Ser Leu Thr 
            20                  25                  30          


Ser Cys Ile Asp Pro Ser Met Gly Leu Asn Glu Glu Gln Lys Glu Phe 
        35                  40                  45              


Gln Lys Val Ala Phe Asp Phe Ala Ala Arg Glu Met Ala Pro Asn Met 
    50                  55                  60                  


Ala Glu Trp Asp Gln Lys Glu Leu Phe Pro Val Asp Val Met Arg Lys 
65                  70                  75                  80  


Ala Ala Gln Leu Gly Phe Gly Gly Val Tyr Ile Gln Thr Asp Val Gly 
                85                  90                  95      


Gly Ser Gly Leu Ser Arg Leu Asp Thr Ser Val Ile Phe Glu Ala Leu 
            100                 105                 110         


Ala Thr Gly Cys Thr Ser Thr Thr Ala Tyr Ile Ser Ile His Asn Met 
        115                 120                 125             


Cys Ala Trp Met Ile Asp Ser Phe Gly Asn Glu Glu Gln Arg His Lys 
    130                 135                 140                 


Phe Cys Pro Pro Leu Cys Thr Met Glu Lys Phe Ala Ser Tyr Cys Leu 
145                 150                 155                 160 


Thr Glu Pro Gly Ser Gly Ser Asp Ala Ala Ser Leu Leu Thr Ser Ala 
                165                 170                 175     


Lys Lys Gln Gly Asp His Tyr Ile Leu Asn Gly Ser Lys Ala Phe Ile 
            180                 185                 190         


Ser Gly Ala Gly Glu Ser Asp Ile Tyr Val Val Met Cys Arg Thr Gly 
        195                 200                 205             


Gly Pro Gly Pro Lys Gly Ile Ser Cys Ile Val Val Glu Lys Gly Thr 
    210                 215                 220                 


Pro Gly Leu Ser Phe Gly Lys Lys Glu Lys Lys Val Gly Trp Asn Ser 
225                 230                 235                 240 


Gln Pro Thr Arg Ala Val Ile Phe Glu Asp Cys Ala Val Pro Val Ala 
                245                 250                 255     


Asn Arg Ile Gly Ser Glu Gly Gln Gly Phe Leu Ile Ala Val Arg Gly 
            260                 265                 270         


Leu Asn Gly Gly Arg Ile Asn Ile Ala Ser Cys Ser Leu Gly Ala Ala 
        275                 280                 285             


His Ala Ser Val Ile Leu Thr Arg Asp His Leu Asn Val Arg Lys Gln 
    290                 295                 300                 


Phe Gly Glu Pro Leu Ala Ser Asn Gln Tyr Leu Gln Phe Thr Leu Ala 
305                 310                 315                 320 


Asp Met Ala Thr Arg Leu Val Ala Ala Arg Leu Met Val Arg Asn Ala 
                325                 330                 335     


Ala Val Ala Leu Gln Glu Glu Arg Lys Asp Ala Val Ala Leu Cys Ser 
            340                 345                 350         


Met Ala Lys Leu Phe Ala Thr Asp Glu Cys Phe Ala Ile Cys Asn Gln 
        355                 360                 365             


Ala Leu Gln Met His Gly Gly Tyr Gly Tyr Leu Lys Asp Tyr Ala Val 
    370                 375                 380                 


Gln Gln Tyr Val Arg Asp Ser Arg Val His Gln Ile Leu Glu Gly Ser 
385                 390                 395                 400 


Asn Glu Val Met Arg Ile Leu Ile Ser Arg Ser Leu Leu Gln Glu 
                405                 410                 415 


<210>  98
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAD9__Homo_sapiens__NP_054768

<400>  98

Met Ser Gly Cys Gly Leu Phe Leu Arg Thr Thr Ala Ala Ala Arg Ala 
1               5                   10                  15      


Cys Arg Gly Leu Val Val Ser Thr Ala Asn Arg Arg Leu Leu Arg Thr 
            20                  25                  30          


Ser Pro Pro Val Arg Ala Phe Ala Lys Glu Leu Phe Leu Gly Lys Ile 
        35                  40                  45              


Lys Lys Lys Glu Val Phe Pro Phe Pro Glu Val Ser Gln Asp Glu Leu 
    50                  55                  60                  


Asn Glu Ile Asn Gln Phe Leu Gly Pro Val Glu Lys Phe Phe Thr Glu 
65                  70                  75                  80  


Glu Val Asp Ser Arg Lys Ile Asp Gln Glu Gly Lys Ile Pro Asp Glu 
                85                  90                  95      


Thr Leu Glu Lys Leu Lys Ser Leu Gly Leu Phe Gly Leu Gln Val Pro 
            100                 105                 110         


Glu Glu Tyr Gly Gly Leu Gly Phe Ser Asn Thr Met Tyr Ser Arg Leu 
        115                 120                 125             


Gly Glu Ile Ile Ser Met Asp Gly Ser Ile Thr Val Thr Leu Ala Ala 
    130                 135                 140                 


His Gln Ala Ile Gly Leu Lys Gly Ile Ile Leu Ala Gly Thr Glu Glu 
145                 150                 155                 160 


Gln Lys Ala Lys Tyr Leu Pro Lys Leu Ala Ser Gly Glu His Ile Ala 
                165                 170                 175     


Ala Phe Cys Leu Thr Glu Pro Ala Ser Gly Ser Asp Ala Ala Ser Ile 
            180                 185                 190         


Arg Ser Arg Ala Thr Leu Ser Glu Asp Lys Lys His Tyr Ile Leu Asn 
        195                 200                 205             


Gly Ser Lys Val Trp Ile Thr Asn Gly Gly Leu Ala Asn Ile Phe Thr 
    210                 215                 220                 


Val Phe Ala Lys Thr Glu Val Val Asp Ser Asp Gly Ser Val Lys Asp 
225                 230                 235                 240 


Lys Ile Thr Ala Phe Ile Val Glu Arg Asp Phe Gly Gly Val Thr Asn 
                245                 250                 255     


Gly Lys Pro Glu Asp Lys Leu Gly Ile Arg Gly Ser Asn Thr Cys Glu 
            260                 265                 270         


Val His Phe Glu Asn Thr Lys Ile Pro Val Glu Asn Ile Leu Gly Glu 
        275                 280                 285             


Val Gly Asp Gly Phe Lys Val Ala Met Asn Ile Leu Asn Ser Gly Arg 
    290                 295                 300                 


Phe Ser Met Gly Ser Val Val Ala Gly Leu Leu Lys Arg Leu Ile Glu 
305                 310                 315                 320 


Met Thr Ala Glu Tyr Ala Cys Thr Arg Lys Gln Phe Asn Lys Arg Leu 
                325                 330                 335     


Ser Glu Phe Gly Leu Ile Gln Glu Lys Phe Ala Leu Met Ala Gln Lys 
            340                 345                 350         


Ala Tyr Val Met Glu Ser Met Thr Tyr Leu Thr Ala Gly Met Leu Asp 
        355                 360                 365             


Gln Pro Gly Phe Pro Asp Cys Ser Ile Glu Ala Ala Met Val Lys Val 
    370                 375                 380                 


Phe Ser Ser Glu Ala Ala Trp Gln Cys Val Ser Glu Ala Leu Gln Ile 
385                 390                 395                 400 


Leu Gly Gly Leu Gly Tyr Thr Arg Asp Tyr Pro Tyr Glu Arg Ile Leu 
                405                 410                 415     


Arg Asp Thr Arg Ile Leu Leu Ile Phe Glu Gly Thr Asn Glu Ile Leu 
            420                 425                 430         


Arg Met Tyr Ile Ala Leu Thr Gly Leu Gln His Ala Gly Arg Ile Leu 
        435                 440                 445             


Thr Thr Arg Ile His Glu Leu Lys Gln Ala Lys Val Ser Thr Val Met 
    450                 455                 460                 


Asp Thr Val Gly Arg Arg Leu Arg Asp Ser Leu Gly Arg Thr Val Asp 
465                 470                 475                 480 


Leu Gly Leu Thr Gly Asn His Gly Val Val His Pro Ser Leu Ala Asp 
                485                 490                 495     


Ser Ala Asn Lys Phe Glu Glu Asn Thr Tyr Cys Phe Gly Arg Thr Val 
            500                 505                 510         


Glu Thr Leu Leu Leu Arg Phe Gly Lys Thr Ile Met Glu Glu Gln Leu 
        515                 520                 525             


Val Leu Lys Arg Val Ala Asn Ile Leu Ile Asn Leu Tyr Gly Met Thr 
    530                 535                 540                 


Ala Val Leu Ser Arg Ala Ser Arg Ser Ile Arg Ile Gly Leu Arg Asn 
545                 550                 555                 560 


His Asp His Glu Val Leu Leu Ala Asn Thr Phe Cys Val Glu Ala Tyr 
                565                 570                 575     


Leu Gln Asn Leu Phe Ser Leu Ser Gln Leu Asp Lys Tyr Ala Pro Glu 
            580                 585                 590         


Asn Leu Asp Glu Gln Ile Lys Lys Val Ser Gln Gln Ile Leu Glu Lys 
        595                 600                 605             


Arg Ala Tyr Ile Cys Ala His Pro Leu Asp Arg Thr Cys 
    610                 615                 620     


<210>  99
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACADL__Homo_sapiens__NP_001599

<400>  99

Met Ala Ala Arg Leu Leu Arg Gly Ser Leu Arg Val Leu Gly Gly His 
1               5                   10                  15      


Arg Ala Pro Arg Gln Leu Pro Ala Ala Arg Cys Ser His Ser Gly Gly 
            20                  25                  30          


Glu Glu Arg Leu Glu Thr Pro Ser Ala Lys Lys Leu Thr Asp Ile Gly 
        35                  40                  45              


Ile Arg Arg Ile Phe Ser Pro Glu His Asp Ile Phe Arg Lys Ser Val 
    50                  55                  60                  


Arg Lys Phe Phe Gln Glu Glu Val Ile Pro His His Ser Glu Trp Glu 
65                  70                  75                  80  


Lys Ala Gly Glu Val Ser Arg Glu Val Trp Glu Lys Ala Gly Lys Gln 
                85                  90                  95      


Gly Leu Leu Gly Val Asn Ile Ala Glu His Leu Gly Gly Ile Gly Gly 
            100                 105                 110         


Asp Leu Tyr Ser Ala Ala Ile Val Trp Glu Glu Gln Ala Tyr Ser Asn 
        115                 120                 125             


Cys Ser Gly Pro Gly Phe Ser Ile His Ser Gly Ile Val Met Ser Tyr 
    130                 135                 140                 


Ile Thr Asn His Gly Ser Glu Glu Gln Ile Lys His Phe Ile Pro Gln 
145                 150                 155                 160 


Met Thr Ala Gly Lys Cys Ile Gly Ala Ile Ala Met Thr Glu Pro Gly 
                165                 170                 175     


Ala Gly Ser Asp Leu Gln Gly Ile Lys Thr Asn Ala Lys Lys Asp Gly 
            180                 185                 190         


Ser Asp Trp Ile Leu Asn Gly Ser Lys Val Phe Ile Ser Asn Gly Ser 
        195                 200                 205             


Leu Ser Asp Val Val Ile Val Val Ala Val Thr Asn His Glu Ala Pro 
    210                 215                 220                 


Ser Pro Ala His Gly Ile Ser Leu Phe Leu Val Glu Asn Gly Met Lys 
225                 230                 235                 240 


Gly Phe Ile Lys Gly Arg Lys Leu His Lys Met Gly Leu Lys Ala Gln 
                245                 250                 255     


Asp Thr Ala Glu Leu Phe Phe Glu Asp Ile Arg Leu Pro Ala Ser Ala 
            260                 265                 270         


Leu Leu Gly Glu Glu Asn Lys Gly Phe Tyr Tyr Ile Met Lys Glu Leu 
        275                 280                 285             


Pro Gln Glu Arg Leu Leu Ile Ala Asp Val Ala Ile Ser Ala Ser Glu 
    290                 295                 300                 


Phe Met Phe Glu Glu Thr Arg Asn Tyr Val Lys Gln Arg Lys Ala Phe 
305                 310                 315                 320 


Gly Lys Thr Val Ala His Leu Gln Thr Val Gln His Lys Leu Ala Glu 
                325                 330                 335     


Leu Lys Thr His Ile Cys Val Thr Arg Ala Phe Val Asp Asn Cys Leu 
            340                 345                 350         


Gln Leu His Glu Ala Lys Arg Leu Asp Ser Ala Thr Ala Cys Met Ala 
        355                 360                 365             


Lys Tyr Trp Ala Ser Glu Leu Gln Asn Ser Val Ala Tyr Asp Cys Val 
    370                 375                 380                 


Gln Leu His Gly Gly Trp Gly Tyr Met Trp Glu Tyr Pro Ile Ala Lys 
385                 390                 395                 400 


Ala Tyr Val Asp Ala Arg Val Gln Pro Ile Tyr Gly Gly Thr Asn Glu 
                405                 410                 415     


Ile Met Lys Glu Leu Ile Ala Arg Glu Ile Val Phe Asp Lys 
            420                 425                 430 


<210>  100
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACADSB__Homo_sapiens__NP_001600

<400>  100

Met Glu Gly Leu Ala Val Arg Leu Leu Arg Gly Ser Arg Leu Leu Arg 
1               5                   10                  15      


Arg Asn Phe Leu Thr Cys Leu Ser Ser Trp Lys Ile Pro Pro His Val 
            20                  25                  30          


Ser Lys Ser Ser Gln Ser Glu Ala Leu Leu Asn Ile Thr Asn Asn Gly 
        35                  40                  45              


Ile His Phe Ala Pro Leu Gln Thr Phe Thr Asp Glu Glu Met Met Ile 
    50                  55                  60                  


Lys Ser Ser Val Lys Lys Phe Ala Gln Glu Gln Ile Ala Pro Leu Val 
65                  70                  75                  80  


Ser Thr Met Asp Glu Asn Ser Lys Met Glu Lys Ser Val Ile Gln Gly 
                85                  90                  95      


Leu Phe Gln Gln Gly Leu Met Gly Ile Glu Val Asp Pro Glu Tyr Gly 
            100                 105                 110         


Gly Thr Gly Ala Ser Phe Leu Ser Thr Val Leu Val Ile Glu Glu Leu 
        115                 120                 125             


Ala Lys Val Asp Ala Ser Val Ala Val Phe Cys Glu Ile Gln Asn Thr 
    130                 135                 140                 


Leu Ile Asn Thr Leu Ile Arg Lys His Gly Thr Glu Glu Gln Lys Ala 
145                 150                 155                 160 


Thr Tyr Leu Pro Gln Leu Thr Thr Glu Lys Val Gly Ser Phe Cys Leu 
                165                 170                 175     


Ser Glu Ala Gly Ala Gly Ser Asp Ser Phe Ala Leu Lys Thr Arg Ala 
            180                 185                 190         


Asp Lys Glu Gly Asp Tyr Tyr Val Leu Asn Gly Ser Lys Met Trp Ile 
        195                 200                 205             


Ser Ser Ala Glu His Ala Gly Leu Phe Leu Val Met Ala Asn Val Asp 
    210                 215                 220                 


Pro Thr Ile Gly Tyr Lys Gly Ile Thr Ser Phe Leu Val Asp Arg Asp 
225                 230                 235                 240 


Thr Pro Gly Leu His Ile Gly Lys Pro Glu Asn Lys Leu Gly Leu Arg 
                245                 250                 255     


Ala Ser Ser Thr Cys Pro Leu Thr Phe Glu Asn Val Lys Val Pro Glu 
            260                 265                 270         


Ala Asn Ile Leu Gly Gln Ile Gly His Gly Tyr Lys Tyr Ala Ile Gly 
        275                 280                 285             


Ser Leu Asn Glu Gly Arg Ile Gly Ile Ala Ala Gln Met Leu Gly Leu 
    290                 295                 300                 


Ala Gln Gly Cys Phe Asp Tyr Thr Ile Pro Tyr Ile Lys Glu Arg Ile 
305                 310                 315                 320 


Gln Phe Gly Lys Arg Leu Phe Asp Phe Gln Gly Leu Gln His Gln Val 
                325                 330                 335     


Ala His Val Ala Thr Gln Leu Glu Ala Ala Arg Leu Leu Thr Tyr Asn 
            340                 345                 350         


Ala Ala Arg Leu Leu Glu Ala Gly Lys Pro Phe Ile Lys Glu Ala Ser 
        355                 360                 365             


Met Ala Lys Tyr Tyr Ala Ser Glu Ile Ala Gly Gln Thr Thr Ser Lys 
    370                 375                 380                 


Cys Ile Glu Trp Met Gly Gly Val Gly Tyr Thr Lys Asp Tyr Pro Val 
385                 390                 395                 400 


Glu Lys Tyr Phe Arg Asp Ala Lys Ile Gly Thr Ile Tyr Glu Gly Ala 
                405                 410                 415     


Ser Asn Ile Gln Leu Asn Thr Ile Ala Lys His Ile Asp Ala Glu Tyr 
            420                 425                 430         


<210>  101
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACADS__Homo_sapiens__NP_000008

<400>  101

Met Ala Ala Ala Leu Leu Ala Arg Ala Ser Gly Pro Ala Arg Arg Ala 
1               5                   10                  15      


Leu Cys Pro Arg Ala Trp Arg Gln Leu His Thr Ile Tyr Gln Ser Val 
            20                  25                  30          


Glu Leu Pro Glu Thr His Gln Met Leu Leu Gln Thr Cys Arg Asp Phe 
        35                  40                  45              


Ala Glu Lys Glu Leu Phe Pro Ile Ala Ala Gln Val Asp Lys Glu His 
    50                  55                  60                  


Leu Phe Pro Ala Ala Gln Val Lys Lys Met Gly Gly Leu Gly Leu Leu 
65                  70                  75                  80  


Ala Met Asp Val Pro Glu Glu Leu Gly Gly Ala Gly Leu Asp Tyr Leu 
                85                  90                  95      


Ala Tyr Ala Ile Ala Met Glu Glu Ile Ser Arg Gly Cys Ala Ser Thr 
            100                 105                 110         


Gly Val Ile Met Ser Val Asn Asn Ser Leu Tyr Leu Gly Pro Ile Leu 
        115                 120                 125             


Lys Phe Gly Ser Lys Glu Gln Lys Gln Ala Trp Val Thr Pro Phe Thr 
    130                 135                 140                 


Ser Gly Asp Lys Ile Gly Cys Phe Ala Leu Ser Glu Pro Gly Asn Gly 
145                 150                 155                 160 


Ser Asp Ala Gly Ala Ala Ser Thr Thr Ala Arg Ala Glu Gly Asp Ser 
                165                 170                 175     


Trp Val Leu Asn Gly Thr Lys Ala Trp Ile Thr Asn Ala Trp Glu Ala 
            180                 185                 190         


Ser Ala Ala Val Val Phe Ala Ser Thr Asp Arg Ala Leu Gln Asn Lys 
        195                 200                 205             


Gly Ile Ser Ala Phe Leu Val Pro Met Pro Thr Pro Gly Leu Thr Leu 
    210                 215                 220                 


Gly Lys Lys Glu Asp Lys Leu Gly Ile Arg Gly Ser Ser Thr Ala Asn 
225                 230                 235                 240 


Leu Ile Phe Glu Asp Cys Arg Ile Pro Lys Asp Ser Ile Leu Gly Glu 
                245                 250                 255     


Pro Gly Met Gly Phe Lys Ile Ala Met Gln Thr Leu Asp Met Gly Arg 
            260                 265                 270         


Ile Gly Ile Ala Ser Gln Ala Leu Gly Ile Ala Gln Thr Ala Leu Asp 
        275                 280                 285             


Cys Ala Val Asn Tyr Ala Glu Asn Arg Met Ala Phe Gly Ala Pro Leu 
    290                 295                 300                 


Thr Lys Leu Gln Val Ile Gln Phe Lys Leu Ala Asp Met Ala Leu Ala 
305                 310                 315                 320 


Leu Glu Ser Ala Arg Leu Leu Thr Trp Arg Ala Ala Met Leu Lys Asp 
                325                 330                 335     


Asn Lys Lys Pro Phe Ile Lys Glu Ala Ala Met Ala Lys Leu Ala Ala 
            340                 345                 350         


Ser Glu Ala Ala Thr Ala Ile Ser His Gln Ala Ile Gln Ile Leu Gly 
        355                 360                 365             


Gly Met Gly Tyr Val Thr Glu Met Pro Ala Glu Arg His Tyr Arg Asp 
    370                 375                 380                 


Ala Arg Ile Thr Glu Ile Tyr Glu Gly Thr Ser Glu Ile Gln Arg Leu 
385                 390                 395                 400 


Val Ile Ala Gly His Leu Leu Arg Ser Tyr Arg Ser 
                405                 410         


<210>  102
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACADVL__Homo_sapiens__NP_000009

<400>  102

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro Arg 
            20                  25                  30          


Pro Gly Pro Ala Arg Arg Pro Tyr Ala Gly Gly Ala Ala Gln Leu Ala 
        35                  40                  45              


Leu Asp Lys Ser Asp Ser His Pro Ser Asp Ala Leu Thr Arg Lys Lys 
    50                  55                  60                  


Pro Ala Lys Ala Glu Ser Lys Ser Phe Ala Val Gly Met Phe Lys Gly 
65                  70                  75                  80  


Gln Leu Thr Thr Asp Gln Val Phe Pro Tyr Pro Ser Val Leu Asn Glu 
                85                  90                  95      


Glu Gln Thr Gln Phe Leu Lys Glu Leu Val Glu Pro Val Ser Arg Phe 
            100                 105                 110         


Phe Glu Glu Val Asn Asp Pro Ala Lys Asn Asp Ala Leu Glu Met Val 
        115                 120                 125             


Glu Glu Thr Thr Trp Gln Gly Leu Lys Glu Leu Gly Ala Phe Gly Leu 
    130                 135                 140                 


Gln Val Pro Ser Glu Leu Gly Gly Val Gly Leu Cys Asn Thr Gln Tyr 
145                 150                 155                 160 


Ala Arg Leu Val Glu Ile Val Gly Met His Asp Leu Gly Val Gly Ile 
                165                 170                 175     


Thr Leu Gly Ala His Gln Ser Ile Gly Phe Lys Gly Ile Leu Leu Phe 
            180                 185                 190         


Gly Thr Lys Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ala Ser Gly 
        195                 200                 205             


Glu Thr Val Ala Ala Phe Cys Leu Thr Glu Pro Ser Ser Gly Ser Asp 
    210                 215                 220                 


Ala Ala Ser Ile Arg Thr Ser Ala Val Pro Ser Pro Cys Gly Lys Tyr 
225                 230                 235                 240 


Tyr Thr Leu Asn Gly Ser Lys Leu Trp Ile Ser Asn Gly Gly Leu Ala 
                245                 250                 255     


Asp Ile Phe Thr Val Phe Ala Lys Thr Pro Val Thr Asp Pro Ala Thr 
            260                 265                 270         


Gly Ala Val Lys Glu Lys Ile Thr Ala Phe Val Val Glu Arg Gly Phe 
        275                 280                 285             


Gly Gly Ile Thr His Gly Pro Pro Glu Lys Lys Met Gly Ile Lys Ala 
    290                 295                 300                 


Ser Asn Thr Ala Glu Val Phe Phe Asp Gly Val Arg Val Pro Ser Glu 
305                 310                 315                 320 


Asn Val Leu Gly Glu Val Gly Ser Gly Phe Lys Val Ala Met His Ile 
                325                 330                 335     


Leu Asn Asn Gly Arg Phe Gly Met Ala Ala Ala Leu Ala Gly Thr Met 
            340                 345                 350         


Arg Gly Ile Ile Ala Lys Ala Val Asp His Ala Thr Asn Arg Thr Gln 
        355                 360                 365             


Phe Gly Glu Lys Ile His Asn Phe Gly Leu Ile Gln Glu Lys Leu Ala 
    370                 375                 380                 


Arg Met Val Met Leu Gln Tyr Val Thr Glu Ser Met Ala Tyr Met Val 
385                 390                 395                 400 


Ser Ala Asn Met Asp Gln Gly Ala Thr Asp Phe Gln Ile Glu Ala Ala 
                405                 410                 415     


Ile Ser Lys Ile Phe Gly Ser Glu Ala Ala Trp Lys Val Thr Asp Glu 
            420                 425                 430         


Cys Ile Gln Ile Met Gly Gly Met Gly Phe Met Lys Glu Pro Gly Val 
        435                 440                 445             


Glu Arg Val Leu Arg Asp Leu Arg Ile Phe Arg Ile Phe Glu Gly Thr 
    450                 455                 460                 


Asn Asp Ile Leu Arg Leu Phe Val Ala Leu Gln Gly Cys Met Asp Lys 
465                 470                 475                 480 


Gly Lys Glu Leu Ser Gly Leu Gly Ser Ala Leu Lys Asn Pro Phe Gly 
                485                 490                 495     


Asn Ala Gly Leu Leu Leu Gly Glu Ala Gly Lys Gln Leu Arg Arg Arg 
            500                 505                 510         


Ala Gly Leu Gly Ser Gly Leu Ser Leu Ser Gly Leu Val His Pro Glu 
        515                 520                 525             


Leu Ser Arg Ser Gly Glu Leu Ala Val Arg Ala Leu Glu Gln Phe Ala 
    530                 535                 540                 


Thr Val Val Glu Ala Lys Leu Ile Lys His Lys Lys Gly Ile Val Asn 
545                 550                 555                 560 


Glu Gln Phe Leu Leu Gln Arg Leu Ala Asp Gly Ala Ile Asp Leu Tyr 
                565                 570                 575     


Ala Met Val Val Val Leu Ser Arg Ala Ser Arg Ser Leu Ser Glu Gly 
            580                 585                 590         


His Pro Thr Ala Gln His Glu Lys Met Leu Cys Asp Thr Trp Cys Ile 
        595                 600                 605             


Glu Ala Ala Ala Arg Ile Arg Glu Gly Met Ala Ala Leu Gln Ser Asp 
    610                 615                 620                 


Pro Trp Gln Gln Glu Leu Tyr Arg Asn Phe Lys Ser Ile Ser Lys Ala 
625                 630                 635                 640 


Leu Val Glu Arg Gly Gly Val Val Thr Ser Asn Pro Leu Gly Phe 
                645                 650                 655 


<210>  103
<211>  2431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAN__Homo_sapiens__NP_001126

<400>  103

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Leu Arg Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Leu Ala Thr Thr 
        595                 600                 605             


Gly Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala 
    610                 615                 620                 


Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
                645                 650                 655     


Pro Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe 
            660                 665                 670         


Cys Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly 
        675                 680                 685             


Gly Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln 
    690                 695                 700                 


Val Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala 
705                 710                 715                 720 


Val Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro 
                725                 730                 735     


Glu Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser 
            740                 745                 750         


Pro Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Ala Thr 
        755                 760                 765             


Glu Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser 
    770                 775                 780                 


Glu Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser 
785                 790                 795                 800 


Pro Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu 
                805                 810                 815     


Leu Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser 
            820                 825                 830         


Glu Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Val 
        835                 840                 845             


Pro Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro 
    850                 855                 860                 


Asp Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu 
865                 870                 875                 880 


Asp Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser 
                885                 890                 895     


Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu 
            900                 905                 910         


Pro Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp 
        915                 920                 925             


Pro Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu 
    930                 935                 940                 


Glu Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly 
945                 950                 955                 960 


Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu 
                965                 970                 975     


Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile 
            980                 985                 990         


Ser Gly Leu Pro Ser Gly Glu Val  Leu Glu Thr Thr Ala  Pro Gly Val 
        995                 1000                 1005             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr 
    1010                 1015                 1020             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1025                 1030                 1035             


Leu Glu  Thr Thr Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1040                 1045                 1050             


Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile 
    1055                 1060                 1065             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly 
    1070                 1075                 1080             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1085                 1090                 1095             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1100                 1105                 1110             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1115                 1120                 1125             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1130                 1135                 1140             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1145                 1150                 1155             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1160                 1165                 1170             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1175                 1180                 1185             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1190                 1195                 1200             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu 
    1205                 1210                 1215             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala 
    1220                 1225                 1230             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1235                 1240                 1245             


Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1250                 1255                 1260             


Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser 
    1265                 1270                 1275             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1280                 1285                 1290             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1295                 1300                 1305             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1310                 1315                 1320             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1325                 1330                 1335             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1340                 1345                 1350             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1370                 1375                 1380             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu Glu Ile  Ser Gly Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala Pro Gly  Val Asp Glu 
    1415                 1420                 1425             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Thr Ala Pro 
    1430                 1435                 1440             


Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1445                 1450                 1455             


Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1460                 1465                 1470             


Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly Val Glu  Asp Ile Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr Ser Ala  Ser Gly Ile 
    1490                 1495                 1500             


Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu Gly Leu  Glu Thr Ser 
    1505                 1510                 1515             


Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Glu 
    1520                 1525                 1530             


Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly Asp Leu  Ser Gly Leu 
    1535                 1540                 1545             


Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser Ala Ser  Glu Val Gly 
    1550                 1555                 1560             


Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Thr 
    1565                 1570                 1575             


Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly Leu Pro  Ser Gly Lys 
    1580                 1585                 1590             


Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp Leu Asp  Leu Gly Lys 
    1595                 1600                 1605             


Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Thr Ser 
    1610                 1615                 1620             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1625                 1630                 1635             


Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1640                 1645                 1650             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Ser Thr  Leu Val Glu 
    1655                 1660                 1665             


Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu Glu Gly  Arg Gly Thr 
    1670                 1675                 1680             


Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser Gly Leu  Pro Ser Ser 
    1685                 1690                 1695             


Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly Leu Pro  Ser Gly Thr 
    1700                 1705                 1710             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Val  Ser Gly Glu 
    1715                 1720                 1725             


Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1730                 1735                 1740             


Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr Glu Leu  Ser Gly Leu 
    1745                 1750                 1755             


Ser Ser  Gly Gln Pro Gly Ile  Ser Gly Glu Ala Ser  Gly Val Leu 
    1760                 1765                 1770             


Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr Asp Leu  Ser Gly Glu 
    1775                 1780                 1785             


Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln Pro Ser  Gly Leu Pro 
    1790                 1795                 1800             


Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro Asp Leu  Val Ser Gly 
    1805                 1810                 1815             


Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly Ile Thr  Phe Val Asp 
    1820                 1825                 1830             


Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr Phe Lys  Glu Glu Glu 
    1835                 1840                 1845             


Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu Pro Ser  Gly Glu Ala 
    1850                 1855                 1860             


Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp Val Ser  Gly Gln Phe 
    1865                 1870                 1875             


Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr Ser Gln  Thr Pro Glu 
    1880                 1885                 1890             


Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu Val Ser  Gly Glu Ser 
    1895                 1900                 1905             


Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro Ser Gly  Ala Tyr Tyr 
    1910                 1915                 1920             


Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr Val Ser  Leu Val Asp 
    1925                 1930                 1935             


Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala Pro Thr  Ala Gln Glu 
    1940                 1945                 1950             


Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu Leu Ser  Gly Ala His 
    1955                 1960                 1965             


Ser Gly  Ala Pro Asp Met Ser  Gly Glu His Ser Gly  Phe Leu Asp 
    1970                 1975                 1980             


Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu Pro Ser  Gly Glu Pro 
    1985                 1990                 1995             


Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe Ala Ser  Thr Thr Asn 
    2000                 2005                 2010             


Val Ser  Gly Glu Ser Ser Val  Ala Met Gly Thr Ser  Gly Glu Ala 
    2015                 2020                 2025             


Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr Ser Glu  Phe Val Glu 
    2030                 2035                 2040             


Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu Leu Gly  Gln Arg Pro 
    2045                 2050                 2055             


Pro Val  Thr His Thr Pro Gln  Leu Phe Glu Ser Ser  Gly Lys Val 
    2060                 2065                 2070             


Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr Pro Val  Leu Pro Gly 
    2075                 2080                 2085             


Ser Gly  Val Glu Val Ser Ser  Val Pro Glu Ser Ser  Ser Glu Thr 
    2090                 2095                 2100             


Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala Ser Ala  Ala Pro Glu 
    2105                 2110                 2115             


Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp Leu Ser  Glu Thr Thr 
    2120                 2125                 2130             


Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg Ser Ser  Gly Leu Gly 
    2135                 2140                 2145             


Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu Gly Glu  Ala Ser Ala 
    2150                 2155                 2160             


Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr Thr Ser  Asp Val Gly 
    2165                 2170                 2175             


Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr Pro Thr  Ala Ser Gly 
    2180                 2185                 2190             


Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser Gly His  Thr Ser Gln 
    2195                 2200                 2205             


Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro Glu Ser  Glu Trp Thr 
    2210                 2215                 2220             


Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His Leu Glu  Ile Glu Ser 
    2225                 2230                 2235             


Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr His Thr  Val Glu Thr 
    2240                 2245                 2250             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Pro Glu Trp 
    2255                 2260                 2265             


Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Asp Gln Glu  Val Cys Glu 
    2270                 2275                 2280             


Glu Gly  Trp Asn Lys Tyr Gln  Gly His Cys Tyr Arg  His Phe Pro 
    2285                 2290                 2295             


Asp Arg  Glu Thr Trp Val Asp  Ala Glu Arg Arg Cys  Arg Glu Gln 
    2300                 2305                 2310             


Gln Ser  His Leu Ser Ser Ile  Val Thr Pro Glu Glu  Gln Glu Phe 
    2315                 2320                 2325             


Val Asn  Asn Asn Ala Gln Asp  Tyr Gln Trp Ile Gly  Leu Asn Asp 
    2330                 2335                 2340             


Arg Thr  Ile Glu Gly Asp Phe  Arg Trp Ser Asp Gly  His Pro Met 
    2345                 2350                 2355             


Gln Phe  Glu Asn Trp Arg Pro  Asn Gln Pro Asp Asn  Phe Phe Ala 
    2360                 2365                 2370             


Ala Gly  Glu Asp Cys Val Val  Met Ile Trp His Glu  Lys Gly Glu 
    2375                 2380                 2385             


Trp Asn  Asp Val Pro Cys Asn  Tyr His Leu Pro Phe  Thr Cys Lys 
    2390                 2395                 2400             


Lys Gly  Thr Ala Thr Thr Tyr  Lys Arg Arg Leu Gln  Lys Arg Ser 
    2405                 2410                 2415             


Ser Arg  His Pro Arg Arg Ser  Arg Pro Ser Thr Ala  His 
    2420                 2425                 2430     


<210>  104
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAT1__Homo_sapiens__NP_000010

<400>  104

Met Ala Val Leu Ala Ala Leu Leu Arg Ser Gly Ala Arg Ser Arg Ser 
1               5                   10                  15      


Pro Leu Leu Arg Arg Leu Val Gln Glu Ile Arg Tyr Val Glu Arg Ser 
            20                  25                  30          


Tyr Val Ser Lys Pro Thr Leu Lys Glu Val Val Ile Val Ser Ala Thr 
        35                  40                  45              


Arg Thr Pro Ile Gly Ser Phe Leu Gly Ser Leu Ser Leu Leu Pro Ala 
    50                  55                  60                  


Thr Lys Leu Gly Ser Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly 
65                  70                  75                  80  


Ile Pro Lys Glu Glu Val Lys Glu Ala Tyr Met Gly Asn Val Leu Gln 
                85                  90                  95      


Gly Gly Glu Gly Gln Ala Pro Thr Arg Gln Ala Val Leu Gly Ala Gly 
            100                 105                 110         


Leu Pro Ile Ser Thr Pro Cys Thr Thr Ile Asn Lys Val Cys Ala Ser 
        115                 120                 125             


Gly Met Lys Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His 
    130                 135                 140                 


Gln Asp Val Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro 
145                 150                 155                 160 


Tyr Val Met Asn Arg Gly Ser Thr Pro Tyr Gly Gly Val Lys Leu Glu 
                165                 170                 175     


Asp Leu Ile Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His 
            180                 185                 190         


Met Gly Ser Cys Ala Glu Asn Thr Ala Lys Lys Leu Asn Ile Ala Arg 
        195                 200                 205             


Asn Glu Gln Asp Ala Tyr Ala Ile Asn Ser Tyr Thr Arg Ser Lys Ala 
    210                 215                 220                 


Ala Trp Glu Ala Gly Lys Phe Gly Asn Glu Val Ile Pro Val Thr Val 
225                 230                 235                 240 


Thr Val Lys Gly Gln Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr 
                245                 250                 255     


Lys Arg Val Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln 
            260                 265                 270         


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp 
        275                 280                 285             


Gly Ala Ala Ala Leu Val Leu Met Thr Ala Asp Ala Ala Lys Arg Leu 
    290                 295                 300                 


Asn Val Thr Pro Leu Ala Arg Ile Val Ala Phe Ala Asp Ala Ala Val 
305                 310                 315                 320 


Glu Pro Ile Asp Phe Pro Ile Ala Pro Val Tyr Ala Ala Ser Met Val 
                325                 330                 335     


Leu Lys Asp Val Gly Leu Lys Lys Glu Asp Ile Ala Met Trp Glu Val 
            340                 345                 350         


Asn Glu Ala Phe Ser Leu Val Val Leu Ala Asn Ile Lys Met Leu Glu 
        355                 360                 365             


Ile Asp Pro Gln Lys Val Asn Ile Asn Gly Gly Ala Val Ser Leu Gly 
    370                 375                 380                 


His Pro Ile Gly Met Ser Gly Ala Arg Ile Val Gly His Leu Thr His 
385                 390                 395                 400 


Ala Leu Lys Gln Gly Glu Tyr Gly Leu Ala Ser Ile Cys Asn Gly Gly 
                405                 410                 415     


Gly Gly Ala Ser Ala Met Leu Ile Gln Lys Leu 
            420                 425         


<210>  105
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACAT2__Homo_sapiens__NP_001290182

<400>  105

Met Gly Ser His Pro Val Leu Arg Ile Trp Gly Asn Arg Arg Ala Thr 
1               5                   10                  15      


Ala Ala Ser Leu Gly Arg Ser Gly Gly Arg Leu Ser Ser Pro Arg Leu 
            20                  25                  30          


Leu Arg Val Val Ala Pro Thr Leu Thr Phe Ala Gln Thr Ser Arg Cys 
        35                  40                  45              


Ser Phe Asn Gly Ala Leu Ala Ala Val Pro Val Gln Asp Leu Gly Ser 
    50                  55                  60                  


Thr Val Ile Lys Glu Val Leu Lys Arg Ala Thr Val Ala Pro Glu Asp 
65                  70                  75                  80  


Val Ser Glu Val Ile Phe Gly His Val Leu Ala Ala Gly Cys Gly Gln 
                85                  90                  95      


Asn Pro Val Arg Gln Ala Ser Val Gly Ala Gly Ile Pro Tyr Ser Val 
            100                 105                 110         


Pro Ala Trp Ser Cys Gln Met Ile Cys Gly Ser Gly Leu Lys Ala Val 
        115                 120                 125             


Cys Leu Ala Val Gln Ser Ile Gly Ile Gly Asp Ser Ser Ile Val Val 
    130                 135                 140                 


Ala Gly Gly Met Glu Asn Met Ser Lys Ala Pro His Leu Ala Tyr Leu 
145                 150                 155                 160 


Arg Thr Gly Val Lys Ile Gly Glu Met Pro Leu Thr Asp Ser Ile Leu 
                165                 170                 175     


Cys Asp Gly Leu Thr Asp Ala Phe His Asn Cys His Met Gly Ile Thr 
            180                 185                 190         


Ala Glu Asn Val Ala Lys Lys Trp Gln Val Ser Arg Glu Asp Gln Asp 
        195                 200                 205             


Lys Val Ala Val Leu Ser Gln Asn Arg Thr Glu Asn Ala Gln Lys Ala 
    210                 215                 220                 


Gly His Phe Asp Lys Glu Ile Val Pro Val Leu Val Ser Thr Arg Lys 
225                 230                 235                 240 


Gly Leu Ile Glu Val Lys Thr Asp Glu Phe Pro Arg His Gly Ser Asn 
                245                 250                 255     


Ile Glu Ala Met Ser Lys Leu Lys Pro Tyr Phe Leu Thr Asp Gly Thr 
            260                 265                 270         


Gly Thr Val Thr Pro Ala Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala 
        275                 280                 285             


Ala Val Val Leu Met Lys Lys Ser Glu Ala Asp Lys Arg Gly Leu Thr 
    290                 295                 300                 


Pro Leu Ala Arg Ile Val Ser Trp Ser Gln Val Gly Val Glu Pro Ser 
305                 310                 315                 320 


Ile Met Gly Ile Gly Pro Ile Pro Ala Ile Lys Gln Ala Val Thr Lys 
                325                 330                 335     


Ala Gly Trp Ser Leu Glu Asp Val Asp Ile Phe Glu Ile Asn Glu Ala 
            340                 345                 350         


Phe Ala Ala Val Ser Ala Ala Ile Val Lys Glu Leu Gly Leu Asn Pro 
        355                 360                 365             


Glu Lys Val Asn Ile Glu Gly Gly Ala Ile Ala Leu Gly His Pro Leu 
    370                 375                 380                 


Gly Ala Ser Gly Cys Arg Ile Leu Val Thr Leu Leu His Thr Leu Glu 
385                 390                 395                 400 


Arg Met Gly Arg Ser Arg Gly Val Ala Ala Leu Cys Ile Gly Gly Gly 
                405                 410                 415     


Met Gly Ile Ala Met Cys Val Gln Arg Glu 
            420                 425     


<210>  106
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACBD3__Homo_sapiens__NP_073572

<400>  106

Met Ala Ala Val Leu Asn Ala Glu Arg Leu Glu Val Ser Val Asp Gly 
1               5                   10                  15      


Leu Thr Leu Ser Pro Asp Pro Glu Glu Arg Pro Gly Ala Glu Gly Ala 
            20                  25                  30          


Pro Leu Leu Pro Pro Pro Leu Pro Pro Pro Ser Pro Pro Gly Ser Gly 
        35                  40                  45              


Arg Gly Pro Gly Ala Ser Gly Glu Gln Pro Glu Pro Gly Glu Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Ala Glu Glu Ala Arg Arg Leu Glu Gln Arg Trp Gly 
65                  70                  75                  80  


Phe Gly Leu Glu Glu Leu Tyr Gly Leu Ala Leu Arg Phe Phe Lys Glu 
                85                  90                  95      


Lys Asp Gly Lys Ala Phe His Pro Thr Tyr Glu Glu Lys Leu Lys Leu 
            100                 105                 110         


Val Ala Leu His Lys Gln Val Leu Met Gly Pro Tyr Asn Pro Asp Thr 
        115                 120                 125             


Cys Pro Glu Val Gly Phe Phe Asp Val Leu Gly Asn Asp Arg Arg Arg 
    130                 135                 140                 


Glu Trp Ala Ala Leu Gly Asn Met Ser Lys Glu Asp Ala Met Val Glu 
145                 150                 155                 160 


Phe Val Lys Leu Leu Asn Arg Cys Cys His Leu Phe Ser Thr Tyr Val 
                165                 170                 175     


Ala Ser His Lys Ile Glu Lys Glu Glu Gln Glu Lys Lys Arg Lys Glu 
            180                 185                 190         


Glu Glu Glu Arg Arg Arg Arg Glu Glu Glu Glu Arg Glu Arg Leu Gln 
        195                 200                 205             


Lys Glu Glu Glu Lys Arg Arg Arg Glu Glu Glu Glu Arg Leu Arg Arg 
    210                 215                 220                 


Glu Glu Glu Glu Arg Arg Arg Ile Glu Glu Glu Arg Leu Arg Leu Glu 
225                 230                 235                 240 


Gln Gln Lys Gln Gln Ile Met Ala Ala Leu Asn Ser Gln Thr Ala Val 
                245                 250                 255     


Gln Phe Gln Gln Tyr Ala Ala Gln Gln Tyr Pro Gly Asn Tyr Glu Gln 
            260                 265                 270         


Gln Gln Ile Leu Ile Arg Gln Leu Gln Glu Gln His Tyr Gln Gln Tyr 
        275                 280                 285             


Met Gln Gln Leu Tyr Gln Val Gln Leu Ala Gln Gln Gln Ala Ala Leu 
    290                 295                 300                 


Gln Lys Gln Gln Glu Val Val Val Ala Gly Ser Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Ser Lys Val Asn Ala Thr Val Pro Ser Asn Met Met Ser Val Asn Gly 
                325                 330                 335     


Gln Ala Lys Thr His Thr Asp Ser Ser Glu Lys Glu Leu Glu Pro Glu 
            340                 345                 350         


Ala Ala Glu Glu Ala Leu Glu Asn Gly Pro Lys Glu Ser Leu Pro Val 
        355                 360                 365             


Ile Ala Ala Pro Ser Met Trp Thr Arg Pro Gln Ile Lys Asp Phe Lys 
    370                 375                 380                 


Glu Lys Ile Gln Gln Asp Ala Asp Ser Val Ile Thr Val Gly Arg Gly 
385                 390                 395                 400 


Glu Val Val Thr Val Arg Val Pro Thr His Glu Glu Gly Ser Tyr Leu 
                405                 410                 415     


Phe Trp Glu Phe Ala Thr Asp Asn Tyr Asp Ile Gly Phe Gly Val Tyr 
            420                 425                 430         


Phe Glu Trp Thr Asp Ser Pro Asn Thr Ala Val Ser Val His Val Ser 
        435                 440                 445             


Glu Ser Ser Asp Asp Asp Glu Glu Glu Glu Glu Asn Ile Gly Cys Glu 
    450                 455                 460                 


Glu Lys Ala Lys Lys Asn Ala Asn Lys Pro Leu Leu Asp Glu Ile Val 
465                 470                 475                 480 


Pro Val Tyr Arg Arg Asp Cys His Glu Glu Val Tyr Ala Gly Ser His 
                485                 490                 495     


Gln Tyr Pro Gly Arg Gly Val Tyr Leu Leu Lys Phe Asp Asn Ser Tyr 
            500                 505                 510         


Ser Leu Trp Arg Ser Lys Ser Val Tyr Tyr Arg Val Tyr Tyr Thr Arg 
        515                 520                 525             


<210>  107
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACBD4__Homo_sapiens__NP_001129176

<400>  107

Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe 
1               5                   10                  15      


Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr 
            20                  25                  30          


Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln 
        35                  40                  45              


Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro 
    50                  55                  60                  


Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser 
65                  70                  75                  80  


Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala 
                85                  90                  95      


Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met 
            100                 105                 110         


Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg 
        115                 120                 125             


Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val 
    130                 135                 140                 


Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys 
145                 150                 155                 160 


Glu Pro Ala Pro Pro Ser Pro Ala Ser Leu Trp Ala Val Thr Leu Pro 
                165                 170                 175     


Thr Pro Pro Gln Ser Pro Ile His Pro Gly Thr Trp Thr Pro Arg Phe 
            180                 185                 190         


Ser Val Ile Pro Trp Ser Ser Trp Ser Leu Ser Trp Phe Gly Gln Ser 
        195                 200                 205             


Ser Gly Gln His Leu Glu Glu Ser Val Ile Pro Gly Thr Ala Pro Cys 
    210                 215                 220                 


Pro Pro Gln Arg Lys Arg Gly Cys Gly Ala Ala Arg Arg Gly Pro Arg 
225                 230                 235                 240 


Ser Trp Thr Cys Gly Cys Trp Gly Gln Phe Glu His Tyr Arg Arg Ala 
                245                 250                 255     


Cys Arg Arg Cys Arg Arg Gly Cys Arg Ala Trp Arg Ala Cys Pro Gly 
            260                 265                 270         


Pro Leu Ser Arg Gly Arg Ser Pro Gly Pro Val Leu Gly His Gly Pro 
        275                 280                 285             


Leu Gly Ser Arg Gly Pro Arg Cys Ser Ser Ser Ser Cys Gly Pro Ser 
    290                 295                 300                 


Ser Ser Ser Gly Ser Ser Glu Cys Phe Gly Pro Lys Arg Gly Asp Cys 
305                 310                 315                 320 


Gln Trp Arg Gly Leu Cys Ser Gln Leu Arg Leu Ser Cys Cys Ala Leu 
                325                 330                 335     


Ser Leu Pro Arg Val 
            340     


<210>  108
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACBD5__Homo_sapiens__NP_001035938

<400>  108

Met Ala Asp Thr Arg Ser Val His Glu Thr Arg Phe Glu Ala Ala Val 
1               5                   10                  15      


Lys Val Ile Gln Ser Leu Pro Lys Asn Gly Ser Phe Gln Pro Thr Asn 
            20                  25                  30          


Glu Met Met Leu Lys Phe Tyr Ser Phe Tyr Lys Gln Ala Thr Glu Gly 
        35                  40                  45              


Pro Cys Lys Leu Ser Arg Pro Gly Phe Trp Asp Pro Ile Gly Arg Tyr 
    50                  55                  60                  


Lys Trp Asp Ala Trp Ser Ser Leu Gly Asp Met Thr Lys Glu Glu Ala 
65                  70                  75                  80  


Met Ile Ala Tyr Val Glu Glu Met Lys Lys Ile Ile Glu Thr Met Pro 
                85                  90                  95      


Met Thr Glu Lys Val Glu Glu Leu Leu Arg Val Ile Gly Pro Phe Tyr 
            100                 105                 110         


Glu Ile Val Glu Asp Lys Lys Ser Gly Arg Ser Ser Asp Ile Thr Ser 
        115                 120                 125             


Asp Leu Gly Asn Val Leu Thr Ser Thr Pro Asn Ala Lys Thr Val Asn 
    130                 135                 140                 


Gly Lys Ala Glu Ser Ser Asp Ser Gly Ala Glu Ser Glu Glu Glu Glu 
145                 150                 155                 160 


Ala Gln Glu Glu Val Lys Gly Ala Glu Gln Ser Asp Asn Asp Lys Lys 
                165                 170                 175     


Met Met Lys Lys Ser Ala Asp His Lys Asn Leu Glu Val Ile Val Thr 
            180                 185                 190         


Asn Gly Tyr Asp Lys Asp Gly Phe Val Gln Asp Ile Gln Asn Asp Ile 
        195                 200                 205             


His Ala Ser Ser Ser Leu Asn Gly Arg Ser Thr Glu Glu Val Lys Pro 
    210                 215                 220                 


Ile Asp Glu Asn Leu Gly Gln Thr Gly Lys Ser Ala Val Cys Ile His 
225                 230                 235                 240 


Gln Asp Ile Asn Asp Asp His Val Glu Asp Val Thr Gly Ile Gln His 
                245                 250                 255     


Leu Thr Ser Asp Ser Asp Ser Glu Val Tyr Cys Asp Ser Met Glu Gln 
            260                 265                 270         


Phe Gly Gln Glu Glu Ser Leu Asp Ser Phe Thr Ser Asn Asn Gly Pro 
        275                 280                 285             


Phe Gln Tyr Tyr Leu Gly Gly His Ser Ser Gln Pro Met Glu Asn Ser 
    290                 295                 300                 


Gly Phe Arg Glu Asp Ile Gln Val Pro Pro Gly Asn Gly Asn Ile Gly 
305                 310                 315                 320 


Asn Met Gln Val Val Ala Val Glu Gly Lys Gly Glu Val Lys His Gly 
                325                 330                 335     


Gly Glu Asp Gly Arg Asn Asn Ser Gly Ala Pro His Arg Glu Lys Arg 
            340                 345                 350         


Gly Gly Glu Thr Asp Glu Phe Ser Asn Val Arg Arg Gly Arg Gly His 
        355                 360                 365             


Arg Met Gln His Leu Ser Glu Gly Thr Lys Gly Arg Gln Val Gly Ser 
    370                 375                 380                 


Gly Gly Asp Gly Glu Arg Trp Gly Ser Asp Arg Gly Ser Arg Gly Ser 
385                 390                 395                 400 


Leu Asn Glu Gln Ile Ala Leu Val Leu Met Arg Leu Gln Glu Asp Met 
                405                 410                 415     


Gln Asn Val Leu Gln Arg Leu Gln Lys Leu Glu Thr Leu Thr Ala Leu 
            420                 425                 430         


Gln Ala Lys Ser Ser Thr Ser Thr Leu Gln Thr Ala Pro Gln Pro Thr 
        435                 440                 445             


Ser Gln Arg Pro Ser Trp Trp Pro Phe Glu Met Ser Pro Gly Val Leu 
    450                 455                 460                 


Thr Phe Ala Ile Ile Trp Pro Phe Ile Ala Gln Trp Leu Val Tyr Leu 
465                 470                 475                 480 


Tyr Tyr Gln Arg Arg Arg Arg Lys Leu Asn 
                485                 490 


<210>  109
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACBD6__Homo_sapiens__NP_115736

<400>  109

Met Ala Ser Ser Phe Leu Pro Ala Gly Ala Ile Thr Gly Asp Ser Gly 
1               5                   10                  15      


Gly Glu Leu Ser Ser Gly Asp Asp Ser Gly Glu Val Glu Phe Pro His 
            20                  25                  30          


Ser Pro Glu Ile Glu Glu Thr Ser Cys Leu Ala Glu Leu Phe Glu Lys 
        35                  40                  45              


Ala Ala Ala His Leu Gln Gly Leu Ile Gln Val Ala Ser Arg Glu Gln 
    50                  55                  60                  


Leu Leu Tyr Leu Tyr Ala Arg Tyr Lys Gln Val Lys Val Gly Asn Cys 
65                  70                  75                  80  


Asn Thr Pro Lys Pro Ser Phe Phe Asp Phe Glu Gly Lys Gln Lys Trp 
                85                  90                  95      


Glu Ala Trp Lys Ala Leu Gly Asp Ser Ser Pro Ser Gln Ala Met Gln 
            100                 105                 110         


Glu Tyr Ile Ala Val Val Lys Lys Leu Asp Pro Gly Trp Asn Pro Gln 
        115                 120                 125             


Ile Pro Glu Lys Lys Gly Lys Glu Ala Asn Thr Gly Phe Gly Gly Pro 
    130                 135                 140                 


Val Ile Ser Ser Leu Tyr His Glu Glu Thr Ile Arg Glu Glu Asp Lys 
145                 150                 155                 160 


Asn Ile Phe Asp Tyr Cys Arg Glu Asn Asn Ile Asp His Ile Thr Lys 
                165                 170                 175     


Ala Ile Lys Ser Lys Asn Val Asp Val Asn Val Lys Asp Glu Glu Gly 
            180                 185                 190         


Arg Ala Leu Leu His Trp Ala Cys Asp Arg Gly His Lys Glu Leu Val 
        195                 200                 205             


Thr Val Leu Leu Gln His Arg Ala Asp Ile Asn Cys Gln Asp Asn Glu 
    210                 215                 220                 


Gly Gln Thr Ala Leu His Tyr Ala Ser Ala Cys Glu Phe Leu Asp Ile 
225                 230                 235                 240 


Val Glu Leu Leu Leu Gln Ser Gly Ala Asp Pro Thr Leu Arg Asp Gln 
                245                 250                 255     


Asp Gly Cys Leu Pro Glu Glu Val Thr Gly Cys Lys Thr Val Ser Leu 
            260                 265                 270         


Val Leu Gln Arg His Thr Thr Gly Lys Ala 
        275                 280         


<210>  110
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACCS__Homo_sapiens__NP_115981

<400>  110

Met Phe Thr Leu Pro Gln Lys Asp Phe Arg Ala Pro Thr Thr Cys Leu 
1               5                   10                  15      


Gly Pro Thr Cys Met Gln Asp Leu Gly Ser Ser His Gly Glu Asp Leu 
            20                  25                  30          


Glu Gly Glu Cys Ser Arg Lys Leu Asp Gln Lys Leu Pro Glu Leu Arg 
        35                  40                  45              


Gly Val Gly Asp Pro Ala Met Ile Ser Ser Asp Thr Ser Tyr Leu Ser 
    50                  55                  60                  


Ser Arg Gly Arg Met Ile Lys Trp Phe Trp Asp Ser Ala Glu Glu Gly 
65                  70                  75                  80  


Tyr Arg Thr Tyr His Met Asp Glu Tyr Asp Glu Asp Lys Asn Pro Ser 
                85                  90                  95      


Gly Ile Ile Asn Leu Gly Thr Ser Glu Asn Lys Leu Cys Phe Asp Leu 
            100                 105                 110         


Leu Ser Trp Arg Leu Ser Gln Arg Asp Met Gln Arg Val Glu Pro Ser 
        115                 120                 125             


Leu Leu Gln Tyr Ala Asp Trp Arg Gly His Leu Phe Leu Arg Glu Glu 
    130                 135                 140                 


Val Ala Lys Phe Leu Ser Phe Tyr Cys Lys Ser Pro Val Pro Leu Arg 
145                 150                 155                 160 


Pro Glu Asn Val Val Val Leu Asn Gly Gly Ala Ser Leu Phe Ser Ala 
                165                 170                 175     


Leu Ala Thr Val Leu Cys Glu Ala Gly Glu Ala Phe Leu Ile Pro Thr 
            180                 185                 190         


Pro Tyr Tyr Gly Ala Ile Thr Gln His Val Cys Leu Tyr Gly Asn Ile 
        195                 200                 205             


Arg Leu Ala Tyr Val Tyr Leu Asp Ser Glu Val Thr Gly Leu Asp Thr 
    210                 215                 220                 


Arg Pro Phe Gln Leu Thr Val Glu Lys Leu Glu Met Ala Leu Arg Glu 
225                 230                 235                 240 


Ala His Ser Glu Gly Val Lys Val Lys Gly Leu Ile Leu Ile Ser Pro 
                245                 250                 255     


Gln Asn Pro Leu Gly Asp Val Tyr Ser Pro Glu Glu Leu Gln Glu Tyr 
            260                 265                 270         


Leu Val Phe Ala Lys Arg His Arg Leu His Val Ile Val Asp Glu Val 
        275                 280                 285             


Tyr Met Leu Ser Val Phe Glu Lys Ser Val Gly Tyr Arg Ser Val Leu 
    290                 295                 300                 


Ser Leu Glu Arg Leu Pro Asp Pro Gln Arg Thr His Val Met Trp Ala 
305                 310                 315                 320 


Thr Ser Lys Asp Phe Gly Met Ser Gly Leu Arg Phe Gly Thr Leu Tyr 
                325                 330                 335     


Thr Glu Asn Gln Asp Val Ala Thr Ala Val Ala Ser Leu Cys Arg Tyr 
            340                 345                 350         


His Gly Leu Ser Gly Leu Val Gln Tyr Gln Met Ala Gln Leu Leu Arg 
        355                 360                 365             


Asp Arg Asp Trp Ile Asn Gln Val Tyr Leu Pro Glu Asn His Ala Arg 
    370                 375                 380                 


Leu Lys Ala Ala His Thr Tyr Val Ser Glu Glu Leu Arg Ala Leu Gly 
385                 390                 395                 400 


Ile Pro Phe Leu Ser Arg Gly Ala Gly Phe Phe Ile Trp Val Asp Leu 
                405                 410                 415     


Arg Lys Tyr Leu Pro Lys Gly Thr Phe Glu Glu Glu Met Leu Leu Trp 
            420                 425                 430         


Arg Arg Phe Leu Asp Asn Lys Val Leu Leu Ser Phe Gly Lys Ala Phe 
        435                 440                 445             


Glu Cys Lys Glu Pro Gly Trp Phe Arg Phe Val Phe Ser Asp Gln Val 
    450                 455                 460                 


His Arg Leu Cys Leu Gly Met Gln Arg Val Gln Gln Val Leu Ala Gly 
465                 470                 475                 480 


Lys Ser Gln Val Ala Glu Asp Pro Arg Pro Ser Gln Ser Gln Glu Pro 
                485                 490                 495     


Ser Asp Gln Arg Arg 
            500     


<210>  111
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACD__Homo_sapiens__NP_001075955

<400>  111

Met Pro Gly Arg Cys Gln Ser Asp Ala Ala Met Arg Val Asn Gly Pro 
1               5                   10                  15      


Ala Ser Arg Ala Pro Ala Gly Trp Thr Ser Gly Ser Leu His Thr Gly 
            20                  25                  30          


Pro Arg Ala Gly Arg Pro Arg Ala Gln Ala Arg Gly Val Arg Gly Arg 
        35                  40                  45              


Gly Leu Leu Leu Arg Pro Arg Pro Ala Lys Glu Leu Pro Leu Pro Arg 
    50                  55                  60                  


Lys Gly Gly Ala Trp Ala Pro Ala Gly Asn Pro Gly Pro Leu His Pro 
65                  70                  75                  80  


Leu Gly Val Ala Val Gly Met Ala Gly Ser Gly Arg Leu Val Leu Arg 
                85                  90                  95      


Pro Trp Ile Arg Glu Leu Ile Leu Gly Ser Glu Thr Pro Ser Ser Pro 
            100                 105                 110         


Arg Ala Gly Gln Leu Leu Glu Val Leu Gln Asp Ala Glu Ala Ala Val 
        115                 120                 125             


Ala Gly Pro Ser His Ala Pro Asp Thr Ser Asp Val Gly Ala Thr Leu 
    130                 135                 140                 


Leu Val Ser Asp Gly Thr His Ser Val Arg Cys Leu Val Thr Arg Glu 
145                 150                 155                 160 


Ala Leu Asp Thr Ser Asp Trp Glu Glu Lys Glu Phe Gly Phe Arg Gly 
                165                 170                 175     


Thr Glu Gly Arg Leu Leu Leu Leu Gln Asp Cys Gly Val His Val Gln 
            180                 185                 190         


Val Ala Glu Gly Gly Ala Pro Ala Glu Phe Tyr Leu Gln Val Asp Arg 
        195                 200                 205             


Phe Ser Leu Leu Pro Thr Glu Gln Pro Arg Leu Arg Val Pro Gly Cys 
    210                 215                 220                 


Asn Gln Asp Leu Asp Val Gln Lys Lys Leu Tyr Asp Cys Leu Glu Glu 
225                 230                 235                 240 


His Leu Ser Glu Ser Thr Ser Ser Asn Ala Gly Leu Ser Leu Ser Gln 
                245                 250                 255     


Leu Leu Asp Glu Met Arg Glu Asp Gln Glu His Gln Gly Ala Leu Val 
            260                 265                 270         


Cys Leu Ala Glu Ser Cys Leu Thr Leu Glu Gly Pro Cys Thr Ala Pro 
        275                 280                 285             


Pro Val Thr His Trp Ala Ala Ser Arg Cys Lys Ala Thr Gly Glu Ala 
    290                 295                 300                 


Val Tyr Thr Val Pro Ser Ser Met Leu Cys Ile Ser Glu Asn Asp Gln 
305                 310                 315                 320 


Leu Ile Leu Ser Ser Leu Gly Pro Cys Gln Arg Thr Gln Gly Pro Glu 
                325                 330                 335     


Leu Pro Pro Pro Asp Pro Ala Leu Gln Asp Leu Ser Leu Thr Leu Ile 
            340                 345                 350         


Ala Ser Pro Pro Ser Ser Pro Ser Ser Ser Gly Thr Pro Ala Leu Pro 
        355                 360                 365             


Gly His Met Ser Ser Glu Glu Ser Gly Thr Ser Ile Ser Leu Leu Pro 
    370                 375                 380                 


Ala Leu Ser Leu Ala Ala Pro Asp Pro Gly Gln Arg Ser Ser Ser Gln 
385                 390                 395                 400 


Pro Ser Pro Ala Ile Cys Ser Ala Pro Ala Thr Leu Thr Pro Arg Ser 
                405                 410                 415     


Pro His Ala Ser Arg Thr Pro Ser Ser Pro Leu Gln Ser Cys Thr Pro 
            420                 425                 430         


Ser Leu Ser Pro Arg Ser His Val Pro Ser Pro His Gln Ala Leu Val 
        435                 440                 445             


Thr Arg Pro Gln Lys Pro Ser Leu Glu Phe Lys Glu Phe Val Gly Leu 
    450                 455                 460                 


Pro Cys Lys Asn Arg Pro Pro Phe Pro Arg Thr Gly Ala Thr Arg Gly 
465                 470                 475                 480 


Ala Gln Glu Pro Cys Ser Val Trp Glu Pro Pro Lys Arg His Arg Asp 
                485                 490                 495     


Gly Ser Ala Phe Gln Tyr Glu Tyr Glu Pro Pro Cys Thr Ser Leu Cys 
            500                 505                 510         


Ala Arg Val Gln Ala Val Arg Leu Pro Pro Gln Leu Met Ala Trp Ala 
        515                 520                 525             


Leu His Phe Leu Met Asp Ala Gln Pro Gly Ser Glu Pro Thr Pro Met 
    530                 535                 540                 


<210>  112
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2__Homo_sapiens__NP_068576

<400>  112

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  113
<211>  1306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE__Homo_sapiens__NP_000780

<400>  113

Met Gly Ala Ala Ser Gly Arg Arg Gly Pro Gly Leu Leu Leu Pro Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Leu Pro Pro Gln Pro Ala Leu Ala Leu Asp Pro 
            20                  25                  30          


Gly Leu Gln Pro Gly Asn Phe Ser Ala Asp Glu Ala Gly Ala Gln Leu 
        35                  40                  45              


Phe Ala Gln Ser Tyr Asn Ser Ser Ala Glu Gln Val Leu Phe Gln Ser 
    50                  55                  60                  


Val Ala Ala Ser Trp Ala His Asp Thr Asn Ile Thr Ala Glu Asn Ala 
65                  70                  75                  80  


Arg Arg Gln Glu Glu Ala Ala Leu Leu Ser Gln Glu Phe Ala Glu Ala 
                85                  90                  95      


Trp Gly Gln Lys Ala Lys Glu Leu Tyr Glu Pro Ile Trp Gln Asn Phe 
            100                 105                 110         


Thr Asp Pro Gln Leu Arg Arg Ile Ile Gly Ala Val Arg Thr Leu Gly 
        115                 120                 125             


Ser Ala Asn Leu Pro Leu Ala Lys Arg Gln Gln Tyr Asn Ala Leu Leu 
    130                 135                 140                 


Ser Asn Met Ser Arg Ile Tyr Ser Thr Ala Lys Val Cys Leu Pro Asn 
145                 150                 155                 160 


Lys Thr Ala Thr Cys Trp Ser Leu Asp Pro Asp Leu Thr Asn Ile Leu 
                165                 170                 175     


Ala Ser Ser Arg Ser Tyr Ala Met Leu Leu Phe Ala Trp Glu Gly Trp 
            180                 185                 190         


His Asn Ala Ala Gly Ile Pro Leu Lys Pro Leu Tyr Glu Asp Phe Thr 
        195                 200                 205             


Ala Leu Ser Asn Glu Ala Tyr Lys Gln Asp Gly Phe Thr Asp Thr Gly 
    210                 215                 220                 


Ala Tyr Trp Arg Ser Trp Tyr Asn Ser Pro Thr Phe Glu Asp Asp Leu 
225                 230                 235                 240 


Glu His Leu Tyr Gln Gln Leu Glu Pro Leu Tyr Leu Asn Leu His Ala 
                245                 250                 255     


Phe Val Arg Arg Ala Leu His Arg Arg Tyr Gly Asp Arg Tyr Ile Asn 
            260                 265                 270         


Leu Arg Gly Pro Ile Pro Ala His Leu Leu Gly Asp Met Trp Ala Gln 
        275                 280                 285             


Ser Trp Glu Asn Ile Tyr Asp Met Val Val Pro Phe Pro Asp Lys Pro 
    290                 295                 300                 


Asn Leu Asp Val Thr Ser Thr Met Leu Gln Gln Gly Trp Asn Ala Thr 
305                 310                 315                 320 


His Met Phe Arg Val Ala Glu Glu Phe Phe Thr Ser Leu Glu Leu Ser 
                325                 330                 335     


Pro Met Pro Pro Glu Phe Trp Glu Gly Ser Met Leu Glu Lys Pro Ala 
            340                 345                 350         


Asp Gly Arg Glu Val Val Cys His Ala Ser Ala Trp Asp Phe Tyr Asn 
        355                 360                 365             


Arg Lys Asp Phe Arg Ile Lys Gln Cys Thr Arg Val Thr Met Asp Gln 
    370                 375                 380                 


Leu Ser Thr Val His His Glu Met Gly His Ile Gln Tyr Tyr Leu Gln 
385                 390                 395                 400 


Tyr Lys Asp Leu Pro Val Ser Leu Arg Arg Gly Ala Asn Pro Gly Phe 
                405                 410                 415     


His Glu Ala Ile Gly Asp Val Leu Ala Leu Ser Val Ser Thr Pro Glu 
            420                 425                 430         


His Leu His Lys Ile Gly Leu Leu Asp Arg Val Thr Asn Asp Thr Glu 
        435                 440                 445             


Ser Asp Ile Asn Tyr Leu Leu Lys Met Ala Leu Glu Lys Ile Ala Phe 
    450                 455                 460                 


Leu Pro Phe Gly Tyr Leu Val Asp Gln Trp Arg Trp Gly Val Phe Ser 
465                 470                 475                 480 


Gly Arg Thr Pro Pro Ser Arg Tyr Asn Phe Asp Trp Trp Tyr Leu Arg 
                485                 490                 495     


Thr Lys Tyr Gln Gly Ile Cys Pro Pro Val Thr Arg Asn Glu Thr His 
            500                 505                 510         


Phe Asp Ala Gly Ala Lys Phe His Val Pro Asn Val Thr Pro Tyr Ile 
        515                 520                 525             


Arg Tyr Phe Val Ser Phe Val Leu Gln Phe Gln Phe His Glu Ala Leu 
    530                 535                 540                 


Cys Lys Glu Ala Gly Tyr Glu Gly Pro Leu His Gln Cys Asp Ile Tyr 
545                 550                 555                 560 


Arg Ser Thr Lys Ala Gly Ala Lys Leu Arg Lys Val Leu Gln Ala Gly 
                565                 570                 575     


Ser Ser Arg Pro Trp Gln Glu Val Leu Lys Asp Met Val Gly Leu Asp 
            580                 585                 590         


Ala Leu Asp Ala Gln Pro Leu Leu Lys Tyr Phe Gln Pro Val Thr Gln 
        595                 600                 605             


Trp Leu Gln Glu Gln Asn Gln Gln Asn Gly Glu Val Leu Gly Trp Pro 
    610                 615                 620                 


Glu Tyr Gln Trp His Pro Pro Leu Pro Asp Asn Tyr Pro Glu Gly Ile 
625                 630                 635                 640 


Asp Leu Val Thr Asp Glu Ala Glu Ala Ser Lys Phe Val Glu Glu Tyr 
                645                 650                 655     


Asp Arg Thr Ser Gln Val Val Trp Asn Glu Tyr Ala Glu Ala Asn Trp 
            660                 665                 670         


Asn Tyr Asn Thr Asn Ile Thr Thr Glu Thr Ser Lys Ile Leu Leu Gln 
        675                 680                 685             


Lys Asn Met Gln Ile Ala Asn His Thr Leu Lys Tyr Gly Thr Gln Ala 
    690                 695                 700                 


Arg Lys Phe Asp Val Asn Gln Leu Gln Asn Thr Thr Ile Lys Arg Ile 
705                 710                 715                 720 


Ile Lys Lys Val Gln Asp Leu Glu Arg Ala Ala Leu Pro Ala Gln Glu 
                725                 730                 735     


Leu Glu Glu Tyr Asn Lys Ile Leu Leu Asp Met Glu Thr Thr Tyr Ser 
            740                 745                 750         


Val Ala Thr Val Cys His Pro Asn Gly Ser Cys Leu Gln Leu Glu Pro 
        755                 760                 765             


Asp Leu Thr Asn Val Met Ala Thr Ser Arg Lys Tyr Glu Asp Leu Leu 
    770                 775                 780                 


Trp Ala Trp Glu Gly Trp Arg Asp Lys Ala Gly Arg Ala Ile Leu Gln 
785                 790                 795                 800 


Phe Tyr Pro Lys Tyr Val Glu Leu Ile Asn Gln Ala Ala Arg Leu Asn 
                805                 810                 815     


Gly Tyr Val Asp Ala Gly Asp Ser Trp Arg Ser Met Tyr Glu Thr Pro 
            820                 825                 830         


Ser Leu Glu Gln Asp Leu Glu Arg Leu Phe Gln Glu Leu Gln Pro Leu 
        835                 840                 845             


Tyr Leu Asn Leu His Ala Tyr Val Arg Arg Ala Leu His Arg His Tyr 
    850                 855                 860                 


Gly Ala Gln His Ile Asn Leu Glu Gly Pro Ile Pro Ala His Leu Leu 
865                 870                 875                 880 


Gly Asn Met Trp Ala Gln Thr Trp Ser Asn Ile Tyr Asp Leu Val Val 
                885                 890                 895     


Pro Phe Pro Ser Ala Pro Ser Met Asp Thr Thr Glu Ala Met Leu Lys 
            900                 905                 910         


Gln Gly Trp Thr Pro Arg Arg Met Phe Lys Glu Ala Asp Asp Phe Phe 
        915                 920                 925             


Thr Ser Leu Gly Leu Leu Pro Val Pro Pro Glu Phe Trp Asn Lys Ser 
    930                 935                 940                 


Met Leu Glu Lys Pro Thr Asp Gly Arg Glu Val Val Cys His Ala Ser 
945                 950                 955                 960 


Ala Trp Asp Phe Tyr Asn Gly Lys Asp Phe Arg Ile Lys Gln Cys Thr 
                965                 970                 975     


Thr Val Asn Leu Glu Asp Leu Val Val Ala His His Glu Met Gly His 
            980                 985                 990         


Ile Gln Tyr Phe Met Gln Tyr Lys  Asp Leu Pro Val Ala  Leu Arg Glu 
        995                 1000                 1005             


Gly Ala  Asn Pro Gly Phe His  Glu Ala Ile Gly Asp  Val Leu Ala 
    1010                 1015                 1020             


Leu Ser  Val Ser Thr Pro Lys  His Leu His Ser Leu  Asn Leu Leu 
    1025                 1030                 1035             


Ser Ser  Glu Gly Gly Ser Asp  Glu His Asp Ile Asn  Phe Leu Met 
    1040                 1045                 1050             


Lys Met  Ala Leu Asp Lys Ile  Ala Phe Ile Pro Phe  Ser Tyr Leu 
    1055                 1060                 1065             


Val Asp  Gln Trp Arg Trp Arg  Val Phe Asp Gly Ser  Ile Thr Lys 
    1070                 1075                 1080             


Glu Asn  Tyr Asn Gln Glu Trp  Trp Ser Leu Arg Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Gly Leu  Cys Pro Pro Val Pro  Arg Thr Gln Gly Asp  Phe Asp Pro 
    1100                 1105                 1110             


Gly Ala  Lys Phe His Ile Pro  Ser Ser Val Pro Tyr  Ile Arg Tyr 
    1115                 1120                 1125             


Phe Val  Ser Phe Ile Ile Gln  Phe Gln Phe His Glu  Ala Leu Cys 
    1130                 1135                 1140             


Gln Ala  Ala Gly His Thr Gly  Pro Leu His Lys Cys  Asp Ile Tyr 
    1145                 1150                 1155             


Gln Ser  Lys Glu Ala Gly Gln  Arg Leu Ala Thr Ala  Met Lys Leu 
    1160                 1165                 1170             


Gly Phe  Ser Arg Pro Trp Pro  Glu Ala Met Gln Leu  Ile Thr Gly 
    1175                 1180                 1185             


Gln Pro  Asn Met Ser Ala Ser  Ala Met Leu Ser Tyr  Phe Lys Pro 
    1190                 1195                 1200             


Leu Leu  Asp Trp Leu Arg Thr  Glu Asn Glu Leu His  Gly Glu Lys 
    1205                 1210                 1215             


Leu Gly  Trp Pro Gln Tyr Asn  Trp Thr Pro Asn Ser  Ala Arg Ser 
    1220                 1225                 1230             


Glu Gly  Pro Leu Pro Asp Ser  Gly Arg Val Ser Phe  Leu Gly Leu 
    1235                 1240                 1245             


Asp Leu  Asp Ala Gln Gln Ala  Arg Val Gly Gln Trp  Leu Leu Leu 
    1250                 1255                 1260             


Phe Leu  Gly Ile Ala Leu Leu  Val Ala Thr Leu Gly  Leu Ser Gln 
    1265                 1270                 1275             


Arg Leu  Phe Ser Ile Arg His  Arg Ser Leu His Arg  His Ser His 
    1280                 1285                 1290             


Gly Pro  Gln Phe Gly Ser Glu  Val Glu Leu Arg His  Ser 
    1295                 1300                 1305     


<210>  114
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACER2__Homo_sapiens__NP_001010887

<400>  114

Met Gly Ala Pro His Trp Trp Asp Gln Leu Gln Ala Gly Ser Ser Glu 
1               5                   10                  15      


Val Asp Trp Cys Glu Asp Asn Tyr Thr Ile Val Pro Ala Ile Ala Glu 
            20                  25                  30          


Phe Tyr Asn Thr Ile Ser Asn Val Leu Phe Phe Ile Leu Pro Pro Ile 
        35                  40                  45              


Cys Met Cys Leu Phe Arg Gln Tyr Ala Thr Cys Phe Asn Ser Gly Ile 
    50                  55                  60                  


Tyr Leu Ile Trp Thr Leu Leu Val Val Val Gly Ile Gly Ser Val Tyr 
65                  70                  75                  80  


Phe His Ala Thr Leu Ser Phe Leu Gly Gln Met Leu Asp Glu Leu Ala 
                85                  90                  95      


Val Leu Trp Val Leu Met Cys Ala Leu Ala Met Trp Phe Pro Arg Arg 
            100                 105                 110         


Tyr Leu Pro Lys Ile Phe Arg Asn Asp Arg Gly Arg Phe Lys Val Val 
        115                 120                 125             


Val Ser Val Leu Ser Ala Val Thr Thr Cys Leu Ala Phe Val Lys Pro 
    130                 135                 140                 


Ala Ile Asn Asn Ile Ser Leu Met Thr Leu Gly Val Pro Cys Thr Ala 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Leu Lys Arg Cys Asp Asn Met Arg Val Phe Lys 
                165                 170                 175     


Leu Gly Leu Phe Ser Gly Leu Trp Trp Thr Leu Ala Leu Phe Cys Trp 
            180                 185                 190         


Ile Ser Asp Arg Ala Phe Cys Glu Leu Leu Ser Ser Phe Asn Phe Pro 
        195                 200                 205             


Tyr Leu His Cys Met Trp His Ile Leu Ile Cys Leu Ala Ala Tyr Leu 
    210                 215                 220                 


Gly Cys Val Cys Phe Ala Tyr Phe Asp Ala Ala Ser Glu Ile Pro Glu 
225                 230                 235                 240 


Gln Gly Pro Val Ile Lys Phe Trp Pro Asn Glu Lys Trp Ala Phe Ile 
                245                 250                 255     


Gly Val Pro Tyr Val Ser Leu Leu Cys Ala Asn Lys Lys Ser Ser Val 
            260                 265                 270         


Lys Ile Thr 
        275 


<210>  115
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACER3__Homo_sapiens__NP_001287882

<400>  115

Met Ala Pro Ala Ala Asp Arg Glu Gly Tyr Trp Gly Pro Thr Thr Ser 
1               5                   10                  15      


Thr Leu Asp Trp Cys Glu Glu Asn Tyr Ser Val Thr Trp Tyr Ile Ala 
            20                  25                  30          


Glu Phe Leu Val Gly Met Gly Ser Trp Cys Phe His Met Thr Leu Lys 
        35                  40                  45              


Tyr Glu Met Gln Leu Leu Asp Glu Leu Pro Met Ile Tyr Ser Cys Cys 
    50                  55                  60                  


Ile Phe Val Tyr Cys Met Phe Glu Cys Phe Lys Ile Lys Asn Ser Val 
65                  70                  75                  80  


Asn Tyr His Leu Leu Phe Thr Leu Val Leu Phe Ser Leu Ile Val Thr 
                85                  90                  95      


Thr Val Tyr Leu Lys Val Lys Glu Pro Ile Phe His Gln Val Met Tyr 
            100                 105                 110         


Gly Met Leu Val Phe Thr Leu Val Leu Arg Ser Ile Tyr Ile Val Thr 
        115                 120                 125             


Trp Val Tyr Pro Trp Leu Arg Gly Leu Gly Tyr Thr Ser Leu Gly Ile 
    130                 135                 140                 


Phe Leu Leu Gly Phe Leu Phe Trp Asn Ile Asp Asn Ile Phe Cys Glu 
145                 150                 155                 160 


Ser Leu Arg Asn Phe Arg Lys Lys Val Pro Pro Ile Ile Gly Ile Thr 
                165                 170                 175     


Thr Gln Phe His Ala Trp Trp His Ile Leu Thr Gly Leu Gly Ser Tyr 
            180                 185                 190         


Leu His Ile Leu Phe Ser Leu Tyr Thr Arg Thr Leu Tyr Leu Arg Tyr 
        195                 200                 205             


Arg Pro Lys Val Lys Phe Leu Phe Gly Ile Trp Pro Val Ile Leu Phe 
    210                 215                 220                 


Glu Pro Leu Arg Lys His 
225                 230 


<210>  116
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACHE__Homo_sapiens__NP_001269378

<400>  116

Met Arg Pro Pro Gln Cys Leu Leu His Thr Pro Ser Leu Ala Ser Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Leu Leu Gly Gly Gly Val Gly Ala Glu 
            20                  25                  30          


Gly Arg Glu Asp Ala Glu Leu Leu Val Thr Val Arg Gly Gly Arg Leu 
        35                  40                  45              


Arg Gly Ile Arg Leu Lys Thr Pro Gly Gly Pro Val Ser Ala Phe Leu 
    50                  55                  60                  


Gly Ile Pro Phe Ala Glu Pro Pro Met Gly Pro Arg Arg Phe Leu Pro 
65                  70                  75                  80  


Pro Glu Pro Lys Gln Pro Trp Ser Gly Val Val Asp Ala Thr Thr Phe 
                85                  90                  95      


Gln Ser Val Cys Tyr Gln Tyr Val Asp Thr Leu Tyr Pro Gly Phe Glu 
            100                 105                 110         


Gly Thr Glu Met Trp Asn Pro Asn Arg Glu Leu Ser Glu Asp Cys Leu 
        115                 120                 125             


Tyr Leu Asn Val Trp Thr Pro Tyr Pro Arg Pro Thr Ser Pro Thr Pro 
    130                 135                 140                 


Val Leu Val Trp Ile Tyr Gly Gly Gly Phe Tyr Ser Gly Ala Ser Ser 
145                 150                 155                 160 


Leu Asp Val Tyr Asp Gly Arg Phe Leu Val Gln Ala Glu Arg Thr Val 
                165                 170                 175     


Leu Val Ser Met Asn Tyr Arg Val Gly Ala Phe Gly Phe Leu Ala Leu 
            180                 185                 190         


Pro Gly Ser Arg Glu Ala Pro Gly Asn Val Gly Leu Leu Asp Gln Arg 
        195                 200                 205             


Leu Ala Leu Gln Trp Val Gln Glu Asn Val Ala Ala Phe Gly Gly Asp 
    210                 215                 220                 


Pro Thr Ser Val Thr Leu Phe Gly Glu Ser Ala Gly Ala Ala Ser Val 
225                 230                 235                 240 


Gly Met His Leu Leu Ser Pro Pro Ser Arg Gly Leu Phe His Arg Ala 
                245                 250                 255     


Val Leu Gln Ser Gly Ala Pro Asn Gly Pro Trp Ala Thr Val Gly Met 
            260                 265                 270         


Gly Glu Ala Arg Arg Arg Ala Thr Gln Leu Ala His Leu Val Gly Cys 
        275                 280                 285             


Pro Pro Gly Gly Thr Gly Gly Asn Asp Thr Glu Leu Val Ala Cys Leu 
    290                 295                 300                 


Arg Thr Arg Pro Ala Gln Val Leu Val Asn His Glu Trp His Val Leu 
305                 310                 315                 320 


Pro Gln Glu Ser Val Phe Arg Phe Ser Phe Val Pro Val Val Asp Gly 
                325                 330                 335     


Asp Phe Leu Ser Asp Thr Pro Glu Ala Leu Ile Asn Ala Gly Asp Phe 
            340                 345                 350         


His Gly Leu Gln Leu Ala Gly Arg Leu Ala Ala Gln Gly Ala Arg Val 
        355                 360                 365             


Tyr Ala Tyr Val Phe Glu His Arg Ala Ser Thr Leu Ser Trp Pro Leu 
    370                 375                 380                 


Trp Met Gly Val Pro His Gly Tyr Glu Ile Glu Phe Ile Phe Gly Ile 
385                 390                 395                 400 


Pro Leu Asp Pro Ser Arg Asn Tyr Thr Ala Glu Glu Lys Ile Phe Ala 
                405                 410                 415     


Gln Arg Leu Met Arg Tyr Trp Ala Asn Phe Ala Arg Thr Gly Asp Pro 
            420                 425                 430         


Asn Glu Pro Arg Asp Pro Lys Ala Pro Gln Trp Pro Pro Tyr Thr Ala 
        435                 440                 445             


Gly Ala Gln Gln Tyr Val Ser Leu Asp Leu Arg Pro Leu Glu Val Arg 
    450                 455                 460                 


Arg Gly Leu Arg Ala Gln Ala Cys Ala Phe Trp Asn Arg Phe Leu Pro 
465                 470                 475                 480 


Lys Leu Leu Ser Ala Thr Asp Thr Leu Asp Glu Ala Glu Arg Gln Trp 
                485                 490                 495     


Lys Ala Glu Phe His Arg Trp Ser Ser Tyr Met Val His Trp Lys Asn 
            500                 505                 510         


Gln Phe Asp His Tyr Ser Lys Gln Asp Arg Cys Ser Asp Leu 
        515                 520                 525     


<210>  117
<211>  1328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACIN1__Homo_sapiens__NP_001158286

<400>  117

Met Trp Arg Arg Lys His Pro Arg Thr Ser Gly Gly Thr Arg Gly Val 
1               5                   10                  15      


Leu Ser Gly Asn Arg Gly Val Glu Tyr Gly Ser Gly Arg Gly His Leu 
            20                  25                  30          


Gly Thr Phe Glu Gly Arg Trp Arg Lys Leu Pro Lys Met Pro Glu Ala 
        35                  40                  45              


Val Gly Thr Asp Pro Ser Thr Ser Arg Lys Met Ala Glu Leu Glu Glu 
    50                  55                  60                  


Val Thr Leu Asp Gly Lys Pro Leu Gln Ala Leu Arg Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Ala Leu Glu Gln Arg Gly Leu Ala Lys Ser Gly Gln Lys Ser 
                85                  90                  95      


Ala Leu Val Lys Arg Leu Lys Gly Ala Leu Met Leu Glu Asn Leu Gln 
            100                 105                 110         


Lys His Ser Thr Pro His Ala Ala Phe Gln Pro Asn Ser Gln Ile Gly 
        115                 120                 125             


Glu Glu Met Ser Gln Asn Ser Phe Ile Lys Gln Tyr Leu Glu Lys Gln 
    130                 135                 140                 


Gln Glu Leu Leu Arg Gln Arg Leu Glu Arg Glu Ala Arg Glu Ala Ala 
145                 150                 155                 160 


Glu Leu Glu Glu Ala Ser Ala Glu Ser Glu Asp Glu Met Ile His Pro 
                165                 170                 175     


Glu Gly Val Ala Ser Leu Leu Pro Pro Asp Phe Gln Ser Ser Leu Glu 
            180                 185                 190         


Arg Pro Glu Leu Glu Leu Ser Arg His Ser Pro Arg Lys Ser Ser Ser 
        195                 200                 205             


Ile Ser Glu Glu Lys Gly Asp Ser Asp Asp Glu Lys Pro Arg Lys Gly 
    210                 215                 220                 


Glu Arg Arg Ser Ser Arg Val Arg Gln Ala Arg Ala Ala Lys Leu Ser 
225                 230                 235                 240 


Glu Gly Ser Gln Pro Ala Glu Glu Glu Glu Asp Gln Glu Thr Pro Ser 
                245                 250                 255     


Arg Asn Leu Arg Val Arg Ala Asp Arg Asn Leu Lys Thr Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Gly 
        275                 280                 285             


Asp Asp Glu Gly Gln Lys Ser Arg Glu Ala Pro Ile Leu Lys Glu Phe 
    290                 295                 300                 


Lys Glu Glu Gly Glu Glu Ile Pro Arg Val Lys Pro Glu Glu Met Met 
305                 310                 315                 320 


Asp Glu Arg Pro Lys Thr Arg Ser Gln Glu Gln Glu Val Leu Glu Arg 
                325                 330                 335     


Gly Gly Arg Phe Thr Arg Ser Gln Glu Glu Ala Arg Lys Ser His Leu 
            340                 345                 350         


Ala Arg Gln Gln Gln Glu Lys Glu Met Lys Thr Thr Ser Pro Leu Glu 
        355                 360                 365             


Glu Glu Glu Arg Glu Ile Lys Ser Ser Gln Gly Leu Lys Glu Lys Ser 
    370                 375                 380                 


Lys Ser Pro Ser Pro Pro Arg Leu Thr Glu Asp Arg Lys Lys Ala Ser 
385                 390                 395                 400 


Leu Val Ala Leu Pro Glu Gln Thr Ala Ser Glu Glu Glu Thr Pro Pro 
                405                 410                 415     


Pro Leu Leu Thr Lys Glu Ala Ser Ser Pro Pro Pro His Pro Gln Leu 
            420                 425                 430         


His Ser Glu Glu Glu Ile Glu Pro Met Glu Gly Pro Ala Pro Pro Val 
        435                 440                 445             


Leu Ile Gln Leu Ser Pro Pro Asn Thr Asp Ala Asp Thr Arg Glu Leu 
    450                 455                 460                 


Leu Val Ser Gln His Thr Val Gln Leu Val Gly Gly Leu Ser Pro Leu 
465                 470                 475                 480 


Ser Ser Pro Ser Asp Thr Lys Ala Glu Ser Pro Ala Glu Lys Val Pro 
                485                 490                 495     


Glu Glu Ser Val Leu Pro Leu Val Gln Lys Ser Thr Leu Ala Asp Tyr 
            500                 505                 510         


Ser Ala Gln Lys Asp Leu Glu Pro Glu Ser Asp Arg Ser Ala Gln Pro 
        515                 520                 525             


Leu Pro Leu Lys Ile Glu Glu Leu Ala Leu Ala Lys Gly Ile Thr Glu 
    530                 535                 540                 


Glu Cys Leu Lys Gln Pro Ser Leu Glu Gln Lys Glu Gly Arg Arg Ala 
545                 550                 555                 560 


Ser His Thr Leu Leu Pro Ser His Arg Leu Lys Gln Ser Ala Asp Ser 
                565                 570                 575     


Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Asp Ser Ser Gly Ser Arg Ser His Ser Pro Leu Arg 
        595                 600                 605             


Ser Lys Gln Arg Asp Val Ala Gln Ala Arg Thr His Ala Asn Pro Arg 
    610                 615                 620                 


Gly Arg Pro Lys Met Gly Ser Arg Ser Thr Ser Glu Ser Arg Ser Arg 
625                 630                 635                 640 


Ser Arg Ser Arg Ser Arg Ser Ala Ser Ser Asn Ser Arg Lys Ser Leu 
                645                 650                 655     


Ser Pro Gly Val Ser Arg Asp Ser Ser Thr Ser Tyr Thr Glu Thr Lys 
            660                 665                 670         


Asp Pro Ser Ser Gly Gln Glu Val Ala Thr Pro Pro Val Pro Gln Leu 
        675                 680                 685             


Gln Val Cys Glu Pro Lys Glu Arg Thr Ser Thr Ser Ser Ser Ser Val 
    690                 695                 700                 


Gln Ala Arg Arg Leu Ser Gln Pro Glu Ser Ala Glu Lys His Val Thr 
705                 710                 715                 720 


Gln Arg Leu Gln Pro Glu Arg Gly Ser Pro Lys Lys Cys Glu Ala Glu 
                725                 730                 735     


Glu Ala Glu Pro Pro Ala Ala Thr Gln Pro Gln Thr Ser Glu Thr Gln 
            740                 745                 750         


Thr Ser His Leu Pro Glu Ser Glu Arg Ile His His Thr Val Glu Glu 
        755                 760                 765             


Lys Glu Glu Val Thr Met Asp Thr Ser Glu Asn Arg Pro Glu Asn Asp 
    770                 775                 780                 


Val Pro Glu Pro Pro Met Pro Ile Ala Asp Gln Val Ser Asn Asp Asp 
785                 790                 795                 800 


Arg Pro Glu Gly Ser Val Glu Asp Glu Glu Lys Lys Glu Ser Ser Leu 
                805                 810                 815     


Pro Lys Ser Phe Lys Arg Lys Ile Ser Val Val Ser Thr Lys Gly Val 
            820                 825                 830         


Pro Ala Gly Asn Ser Asp Thr Glu Gly Gly Gln Pro Gly Arg Lys Arg 
        835                 840                 845             


Arg Trp Gly Ala Ser Thr Ala Thr Thr Gln Lys Lys Pro Ser Ile Ser 
    850                 855                 860                 


Ile Thr Thr Glu Ser Leu Lys Glu Ala Val Val Asp Leu His Ala Asp 
865                 870                 875                 880 


Asp Ser Arg Ile Ser Glu Asp Glu Thr Glu Arg Asn Gly Asp Asp Gly 
                885                 890                 895     


Thr His Asp Lys Gly Leu Lys Ile Cys Arg Thr Val Thr Gln Val Val 
            900                 905                 910         


Pro Ala Glu Gly Gln Glu Asn Gly Gln Arg Glu Glu Glu Glu Glu Glu 
        915                 920                 925             


Lys Glu Pro Glu Ala Glu Pro Pro Val Pro Pro Gln Val Ser Val Glu 
    930                 935                 940                 


Val Ala Leu Pro Pro Pro Ala Glu His Glu Val Lys Lys Val Thr Leu 
945                 950                 955                 960 


Gly Asp Thr Leu Thr Arg Arg Ser Ile Ser Gln Gln Lys Ser Gly Val 
                965                 970                 975     


Ser Ile Thr Ile Asp Asp Pro Val Arg Thr Ala Gln Val Pro Ser Pro 
            980                 985                 990         


Pro Arg Gly Lys Ile Ser Asn Ile  Val His Ile Ser Asn  Leu Val Arg 
        995                 1000                 1005             


Pro Phe  Thr Leu Gly Gln Leu  Lys Glu Leu Leu Gly  Arg Thr Gly 
    1010                 1015                 1020             


Thr Leu  Val Glu Glu Ala Phe  Trp Ile Asp Lys Ile  Lys Ser His 
    1025                 1030                 1035             


Cys Phe  Val Thr Tyr Ser Thr  Val Glu Glu Ala Val  Ala Thr Arg 
    1040                 1045                 1050             


Thr Ala  Leu His Gly Val Lys  Trp Pro Gln Ser Asn  Pro Lys Phe 
    1055                 1060                 1065             


Leu Cys  Ala Asp Tyr Ala Glu  Gln Asp Glu Leu Asp  Tyr His Arg 
    1070                 1075                 1080             


Gly Leu  Leu Val Asp Arg Pro  Ser Glu Thr Lys Thr  Glu Glu Gln 
    1085                 1090                 1095             


Gly Ile  Pro Arg Pro Leu His  Pro Pro Pro Pro Pro  Pro Val Gln 
    1100                 1105                 1110             


Pro Pro  Gln His Pro Arg Ala  Glu Gln Arg Glu Gln  Glu Arg Ala 
    1115                 1120                 1125             


Val Arg  Glu Gln Trp Ala Glu  Arg Glu Arg Glu Met  Glu Arg Arg 
    1130                 1135                 1140             


Glu Arg  Thr Arg Ser Glu Arg  Glu Trp Asp Arg Asp  Lys Val Arg 
    1145                 1150                 1155             


Glu Gly  Pro Arg Ser Arg Ser  Arg Ser Arg Asp Arg  Arg Arg Lys 
    1160                 1165                 1170             


Glu Arg  Ala Lys Ser Lys Glu  Lys Lys Ser Glu Lys  Lys Glu Lys 
    1175                 1180                 1185             


Ala Gln  Glu Glu Pro Pro Ala  Lys Leu Leu Asp Asp  Leu Phe Arg 
    1190                 1195                 1200             


Lys Thr  Lys Ala Ala Pro Cys  Ile Tyr Trp Leu Pro  Leu Thr Asp 
    1205                 1210                 1215             


Ser Gln  Ile Val Gln Lys Glu  Ala Glu Arg Ala Glu  Arg Ala Lys 
    1220                 1225                 1230             


Glu Arg  Glu Lys Arg Arg Lys  Glu Gln Glu Glu Glu  Glu Gln Lys 
    1235                 1240                 1245             


Glu Arg  Glu Lys Glu Ala Glu  Arg Glu Arg Asn Arg  Gln Leu Glu 
    1250                 1255                 1260             


Arg Glu  Lys Arg Arg Glu His  Ser Arg Glu Arg Asp  Arg Glu Arg 
    1265                 1270                 1275             


Glu Arg  Glu Arg Glu Arg Asp  Arg Gly Asp Arg Asp  Arg Asp Arg 
    1280                 1285                 1290             


Glu Arg  Asp Arg Glu Arg Gly  Arg Glu Arg Asp Arg  Arg Asp Thr 
    1295                 1300                 1305             


Lys Arg  His Ser Arg Ser Arg  Ser Arg Ser Thr Pro  Val Arg Asp 
    1310                 1315                 1320             


Arg Gly  Gly Arg Arg 
    1325             


<210>  118
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACKR1__Homo_sapiens__NP_001116423

<400>  118

Met Ala Ser Ser Gly Tyr Val Leu Gln Ala Glu Leu Ser Pro Ser Thr 
1               5                   10                  15      


Glu Asn Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr 
            20                  25                  30          


Gly Val Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu 
        35                  40                  45              


Ala Ala Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Leu 
    50                  55                  60                  


Pro Phe Phe Ile Leu Thr Ser Val Leu Gly Ile Leu Ala Ser Ser Thr 
65                  70                  75                  80  


Val Leu Phe Met Leu Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro 
                85                  90                  95      


Gly Trp Pro Val Leu Ala Gln Leu Ala Val Gly Ser Ala Leu Phe Ser 
            100                 105                 110         


Ile Val Val Pro Val Leu Ala Pro Gly Leu Gly Ser Thr Arg Ser Ser 
        115                 120                 125             


Ala Leu Cys Ser Leu Gly Tyr Cys Val Trp Tyr Gly Ser Ala Phe Ala 
    130                 135                 140                 


Gln Ala Leu Leu Leu Gly Cys His Ala Ser Leu Gly His Arg Leu Gly 
145                 150                 155                 160 


Ala Gly Gln Val Pro Gly Leu Thr Leu Gly Leu Thr Val Gly Ile Trp 
                165                 170                 175     


Gly Val Ala Ala Leu Leu Thr Leu Pro Val Thr Leu Ala Ser Gly Ala 
            180                 185                 190         


Ser Gly Gly Leu Cys Thr Leu Ile Tyr Ser Thr Glu Leu Lys Ala Leu 
        195                 200                 205             


Gln Ala Thr His Thr Val Ala Cys Leu Ala Ile Phe Val Leu Leu Pro 
    210                 215                 220                 


Leu Gly Leu Phe Gly Ala Lys Gly Leu Lys Lys Ala Leu Gly Met Gly 
225                 230                 235                 240 


Pro Gly Pro Trp Met Asn Ile Leu Trp Ala Trp Phe Ile Phe Trp Trp 
                245                 250                 255     


Pro His Gly Val Val Leu Gly Leu Asp Phe Leu Val Arg Ser Lys Leu 
            260                 265                 270         


Leu Leu Leu Ser Thr Cys Leu Ala Gln Gln Ala Leu Asp Leu Leu Leu 
        275                 280                 285             


Asn Leu Ala Glu Ala Leu Ala Ile Leu His Cys Val Ala Thr Pro Leu 
    290                 295                 300                 


Leu Leu Ala Leu Phe Cys His Gln Ala Thr Arg Thr Leu Leu Pro Ser 
305                 310                 315                 320 


Leu Pro Leu Pro Glu Gly Trp Ser Ser His Leu Asp Thr Leu Gly Ser 
                325                 330                 335     


Lys Ser 
        


<210>  119
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACKR2__Homo_sapiens__NP_001287

<400>  119

Met Ala Ala Thr Ala Ser Pro Gln Pro Leu Ala Thr Glu Asp Ala Asp 
1               5                   10                  15      


Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala 
            20                  25                  30          


Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe 
        35                  40                  45              


Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn 
    50                  55                  60                  


Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met 
65                  70                  75                  80  


Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu 
                85                  90                  95      


Val Thr Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe 
            100                 105                 110         


Gly Ser Phe Leu Cys Lys Met Val Ser Thr Leu Tyr Thr Ile Asn Phe 
        115                 120                 125             


Tyr Ser Gly Ile Phe Phe Ile Ser Cys Met Ser Leu Asp Lys Tyr Leu 
    130                 135                 140                 


Glu Ile Val His Ala Gln Pro Tyr His Arg Leu Arg Thr Arg Ala Lys 
145                 150                 155                 160 


Ser Leu Leu Leu Ala Thr Ile Val Trp Ala Val Ser Leu Ala Val Ser 
                165                 170                 175     


Ile Pro Asp Met Val Phe Val Gln Thr His Glu Asn Pro Lys Gly Val 
            180                 185                 190         


Trp Asn Cys His Ala Asp Phe Gly Gly His Gly Thr Ile Trp Lys Leu 
        195                 200                 205             


Phe Leu Arg Phe Gln Gln Asn Leu Leu Gly Phe Leu Leu Pro Leu Leu 
    210                 215                 220                 


Ala Met Ile Phe Phe Tyr Ser Arg Ile Gly Cys Val Leu Val Arg Leu 
225                 230                 235                 240 


Arg Pro Ala Gly Gln Gly Arg Ala Leu Lys Ile Ala Ala Ala Leu Val 
                245                 250                 255     


Val Ala Phe Phe Val Leu Trp Phe Pro Tyr Asn Leu Thr Leu Phe Leu 
            260                 265                 270         


His Thr Leu Leu Asp Leu Gln Val Phe Gly Asn Cys Glu Val Ser Gln 
        275                 280                 285             


His Leu Asp Tyr Ala Leu Gln Val Thr Glu Ser Ile Ala Phe Leu His 
    290                 295                 300                 


Cys Cys Phe Ser Pro Ile Leu Tyr Ala Phe Ser Ser His Arg Phe Arg 
305                 310                 315                 320 


Gln Tyr Leu Lys Ala Phe Leu Ala Ala Val Leu Gly Trp His Leu Ala 
                325                 330                 335     


Pro Gly Thr Ala Gln Ala Ser Leu Ser Ser Cys Ser Glu Ser Ser Ile 
            340                 345                 350         


Leu Thr Ala Gln Glu Glu Met Thr Gly Met Asn Asp Leu Gly Glu Arg 
        355                 360                 365             


Gln Ser Glu Asn Tyr Pro Asn Lys Glu Asp Val Gly Asn Lys Ser Ala 
    370                 375                 380                 


<210>  120
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACKR3__Homo_sapiens__XP_005246155

<400>  120

Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser 
        35                  40                  45              


Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val 
    50                  55                  60                  


Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His 
65                  70                  75                  80  


Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr 
                85                  90                  95      


Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu 
        115                 120                 125             


Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val 
145                 150                 155                 160 


Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser 
                165                 170                 175     


Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro 
    210                 215                 220                 


Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser 
225                 230                 235                 240 


Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser 
                245                 250                 255     


Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val 
            260                 265                 270         


Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg 
        275                 280                 285             


Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser 
    290                 295                 300                 


Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg 
305                 310                 315                 320 


Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala 
                325                 330                 335     


Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr 
            340                 345                 350         


Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys 
        355                 360         


<210>  121
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACKR4__Homo_sapiens__NP_848540

<400>  121

Met Ala Leu Glu Gln Asn Gln Ser Thr Asp Tyr Tyr Tyr Glu Glu Asn 
1               5                   10                  15      


Glu Met Asn Gly Thr Tyr Asp Tyr Ser Gln Tyr Glu Leu Ile Cys Ile 
            20                  25                  30          


Lys Glu Asp Val Arg Glu Phe Ala Lys Val Phe Leu Pro Val Phe Leu 
        35                  40                  45              


Thr Ile Val Phe Val Ile Gly Leu Ala Gly Asn Ser Met Val Val Ala 
    50                  55                  60                  


Ile Tyr Ala Tyr Tyr Lys Lys Gln Arg Thr Lys Thr Asp Val Tyr Ile 
65                  70                  75                  80  


Leu Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Phe Thr Leu Pro Phe 
                85                  90                  95      


Trp Ala Val Asn Ala Val His Gly Trp Val Leu Gly Lys Ile Met Cys 
            100                 105                 110         


Lys Ile Thr Ser Ala Leu Tyr Thr Leu Asn Phe Val Ser Gly Met Gln 
        115                 120                 125             


Phe Leu Ala Cys Ile Ser Ile Asp Arg Tyr Val Ala Val Thr Lys Val 
    130                 135                 140                 


Pro Ser Gln Ser Gly Val Gly Lys Pro Cys Trp Ile Ile Cys Phe Cys 
145                 150                 155                 160 


Val Trp Met Ala Ala Ile Leu Leu Ser Ile Pro Gln Leu Val Phe Tyr 
                165                 170                 175     


Thr Val Asn Asp Asn Ala Arg Cys Ile Pro Ile Phe Pro Arg Tyr Leu 
            180                 185                 190         


Gly Thr Ser Met Lys Ala Leu Ile Gln Met Leu Glu Ile Cys Ile Gly 
        195                 200                 205             


Phe Val Val Pro Phe Leu Ile Met Gly Val Cys Tyr Phe Ile Thr Ala 
    210                 215                 220                 


Arg Thr Leu Met Lys Met Pro Asn Ile Lys Ile Ser Arg Pro Leu Lys 
225                 230                 235                 240 


Val Leu Leu Thr Val Val Ile Val Phe Ile Val Thr Gln Leu Pro Tyr 
                245                 250                 255     


Asn Ile Val Lys Phe Cys Arg Ala Ile Asp Ile Ile Tyr Ser Leu Ile 
            260                 265                 270         


Thr Ser Cys Asn Met Ser Lys Arg Met Asp Ile Ala Ile Gln Val Thr 
        275                 280                 285             


Glu Ser Ile Ala Leu Phe His Ser Cys Leu Asn Pro Ile Leu Tyr Val 
    290                 295                 300                 


Phe Met Gly Ala Ser Phe Lys Asn Tyr Val Met Lys Val Ala Lys Lys 
305                 310                 315                 320 


Tyr Gly Ser Trp Arg Arg Gln Arg Gln Ser Val Glu Glu Phe Pro Phe 
                325                 330                 335     


Asp Ser Glu Gly Pro Thr Glu Pro Thr Ser Thr Phe Ser Ile 
            340                 345                 350 


<210>  122
<211>  1155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACLY__Homo_sapiens__NP_001290203

<400>  122

Met Gly Ala Gly Lys Ser Pro Ala Gly Pro Gly Gln Lys Pro Asp Pro 
1               5                   10                  15      


Gly Lys Leu Pro Ala Ala Gly Val Leu Arg Ile Leu Arg Gly Ser Ser 
            20                  25                  30          


Gly Leu Trp Lys Lys Arg Arg Ala Arg Thr Ser Ala Glu Thr Gly Arg 
        35                  40                  45              


Ala Gly Leu Ser Ala Ala Met Ser Ala Lys Ala Ile Ser Glu Gln Thr 
    50                  55                  60                  


Gly Lys Glu Leu Leu Tyr Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln 
65                  70                  75                  80  


Asn Arg Phe Lys Tyr Ala Arg Val Thr Pro Asp Thr Asp Trp Ala Arg 
                85                  90                  95      


Leu Leu Gln Asp His Pro Trp Leu Leu Ser Gln Asn Leu Val Val Lys 
            100                 105                 110         


Pro Asp Gln Leu Ile Lys Arg Arg Gly Lys Leu Gly Leu Val Gly Val 
        115                 120                 125             


Asn Leu Thr Leu Asp Gly Val Lys Ser Trp Leu Lys Pro Arg Leu Gly 
    130                 135                 140                 


Gln Glu Ala Thr Val Gly Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu 
145                 150                 155                 160 


Ile Glu Pro Phe Val Pro His Ser Gln Ala Glu Glu Phe Tyr Val Cys 
                165                 170                 175     


Ile Tyr Ala Thr Arg Glu Gly Asp Tyr Val Leu Phe His His Glu Gly 
            180                 185                 190         


Gly Val Asp Val Gly Asp Val Asp Ala Lys Ala Gln Lys Leu Leu Val 
        195                 200                 205             


Gly Val Asp Glu Lys Leu Asn Pro Glu Asp Ile Lys Lys His Leu Leu 
    210                 215                 220                 


Val His Ala Pro Glu Asp Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser 
225                 230                 235                 240 


Gly Leu Phe Asn Phe Tyr Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile 
                245                 250                 255     


Asn Pro Leu Val Val Thr Lys Asp Gly Val Tyr Val Leu Asp Leu Ala 
            260                 265                 270         


Ala Lys Val Asp Ala Thr Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly 
        275                 280                 285             


Asp Ile Glu Phe Pro Pro Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu 
    290                 295                 300                 


Ala Tyr Ile Ala Asp Leu Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu 
305                 310                 315                 320 


Thr Leu Leu Asn Pro Lys Gly Arg Ile Trp Thr Met Val Ala Gly Gly 
                325                 330                 335     


Gly Ala Ser Val Val Tyr Ser Asp Thr Ile Cys Asp Leu Gly Gly Val 
            340                 345                 350         


Asn Glu Leu Ala Asn Tyr Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln 
        355                 360                 365             


Gln Thr Tyr Asp Tyr Ala Lys Thr Ile Leu Ser Leu Met Thr Arg Glu 
    370                 375                 380                 


Lys His Pro Asp Gly Lys Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn 
385                 390                 395                 400 


Phe Thr Asn Val Ala Ala Thr Phe Lys Gly Ile Val Arg Ala Ile Arg 
                405                 410                 415     


Asp Tyr Gln Gly Pro Leu Lys Glu His Glu Val Thr Ile Phe Val Arg 
            420                 425                 430         


Arg Gly Gly Pro Asn Tyr Gln Glu Gly Leu Arg Val Met Gly Glu Val 
        435                 440                 445             


Gly Lys Thr Thr Gly Ile Pro Ile His Val Phe Gly Thr Glu Thr His 
    450                 455                 460                 


Met Thr Ala Ile Val Gly Met Ala Leu Gly His Arg Pro Ile Pro Asn 
465                 470                 475                 480 


Gln Pro Pro Thr Ala Ala His Thr Ala Asn Phe Leu Leu Asn Ala Ser 
                485                 490                 495     


Gly Ser Thr Ser Thr Pro Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu 
            500                 505                 510         


Ser Arg Ala Asp Glu Val Ala Pro Ala Lys Lys Ala Lys Pro Ala Met 
        515                 520                 525             


Pro Gln Asp Ser Val Pro Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr 
    530                 535                 540                 


Thr Leu Phe Ser Arg His Thr Lys Ala Ile Val Trp Gly Met Gln Thr 
545                 550                 555                 560 


Arg Ala Val Gln Gly Met Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp 
                565                 570                 575     


Glu Pro Ser Val Ala Ala Met Val Tyr Pro Phe Thr Gly Asp His Lys 
            580                 585                 590         


Gln Lys Phe Tyr Trp Gly His Lys Glu Ile Leu Ile Pro Val Phe Lys 
        595                 600                 605             


Asn Met Ala Asp Ala Met Arg Lys His Pro Glu Val Asp Val Leu Ile 
    610                 615                 620                 


Asn Phe Ala Ser Leu Arg Ser Ala Tyr Asp Ser Thr Met Glu Thr Met 
625                 630                 635                 640 


Asn Tyr Ala Gln Ile Arg Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro 
                645                 650                 655     


Glu Ala Leu Thr Arg Lys Leu Ile Lys Lys Ala Asp Gln Lys Gly Val 
            660                 665                 670         


Thr Ile Ile Gly Pro Ala Thr Val Gly Gly Ile Lys Pro Gly Cys Phe 
        675                 680                 685             


Lys Ile Gly Asn Thr Gly Gly Met Leu Asp Asn Ile Leu Ala Ser Lys 
    690                 695                 700                 


Leu Tyr Arg Pro Gly Ser Val Ala Tyr Val Ser Arg Ser Gly Gly Met 
705                 710                 715                 720 


Ser Asn Glu Leu Asn Asn Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr 
                725                 730                 735     


Glu Gly Val Ala Ile Gly Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met 
            740                 745                 750         


Asp His Val Leu Arg Tyr Gln Asp Thr Pro Gly Val Lys Met Ile Val 
        755                 760                 765             


Val Leu Gly Glu Ile Gly Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly 
    770                 775                 780                 


Ile Lys Glu Gly Arg Leu Thr Lys Pro Ile Val Cys Trp Cys Ile Gly 
785                 790                 795                 800 


Thr Cys Ala Thr Met Phe Ser Ser Glu Val Gln Phe Gly His Ala Gly 
                805                 810                 815     


Ala Cys Ala Asn Gln Ala Ser Glu Thr Ala Val Ala Lys Asn Gln Ala 
            820                 825                 830         


Leu Lys Glu Ala Gly Val Phe Val Pro Arg Ser Phe Asp Glu Leu Gly 
        835                 840                 845             


Glu Ile Ile Gln Ser Val Tyr Glu Asp Leu Val Ala Asn Gly Val Ile 
    850                 855                 860                 


Val Pro Ala Gln Glu Val Pro Pro Pro Thr Val Pro Met Asp Tyr Ser 
865                 870                 875                 880 


Trp Ala Arg Glu Leu Gly Leu Ile Arg Lys Pro Ala Ser Phe Met Thr 
                885                 890                 895     


Ser Ile Cys Asp Glu Arg Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro 
            900                 905                 910         


Ile Thr Glu Val Phe Lys Glu Glu Met Gly Ile Gly Gly Val Leu Gly 
        915                 920                 925             


Leu Leu Trp Phe Gln Lys Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile 
    930                 935                 940                 


Glu Met Cys Leu Met Val Thr Ala Asp His Gly Pro Ala Val Ser Gly 
945                 950                 955                 960 


Ala His Asn Thr Ile Ile Cys Ala Arg Ala Gly Lys Asp Leu Val Ser 
                965                 970                 975     


Ser Leu Thr Ser Gly Leu Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala 
            980                 985                 990         


Leu Asp Ala Ala Ala Lys Met Phe  Ser Lys Ala Phe Asp  Ser Gly Ile 
        995                 1000                 1005             


Ile Pro  Met Glu Phe Val Asn  Lys Met Lys Lys Glu  Gly Lys Leu 
    1010                 1015                 1020             


Ile Met  Gly Ile Gly His Arg  Val Lys Ser Ile Asn  Asn Pro Asp 
    1025                 1030                 1035             


Met Arg  Val Gln Ile Leu Lys  Asp Tyr Val Arg Gln  His Phe Pro 
    1040                 1045                 1050             


Ala Thr  Pro Leu Leu Asp Tyr  Ala Leu Glu Val Glu  Lys Ile Thr 
    1055                 1060                 1065             


Thr Ser  Lys Lys Pro Asn Leu  Ile Leu Asn Val Asp  Gly Leu Ile 
    1070                 1075                 1080             


Gly Val  Ala Phe Val Asp Met  Leu Arg Asn Cys Gly  Ser Phe Thr 
    1085                 1090                 1095             


Arg Glu  Glu Ala Asp Glu Tyr  Ile Asp Ile Gly Ala  Leu Asn Gly 
    1100                 1105                 1110             


Ile Phe  Val Leu Gly Arg Ser  Met Gly Phe Ile Gly  His Tyr Leu 
    1115                 1120                 1125             


Asp Gln  Lys Arg Leu Lys Gln  Gly Leu Tyr Arg His  Pro Trp Asp 
    1130                 1135                 1140             


Asp Ile  Ser Tyr Val Leu Pro  Glu His Met Ser Met  
    1145                 1150                 1155 


<210>  123
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACMSD__Homo_sapiens__NP_612199

<400>  123

Met Lys Ile Asp Ile His Ser His Ile Leu Pro Lys Glu Trp Pro Asp 
1               5                   10                  15      


Leu Lys Lys Arg Phe Gly Tyr Gly Gly Trp Val Gln Leu Gln His His 
            20                  25                  30          


Ser Lys Gly Glu Ala Lys Leu Leu Lys Asp Gly Lys Val Phe Arg Val 
        35                  40                  45              


Val Arg Glu Asn Cys Trp Asp Pro Glu Val Arg Ile Arg Glu Met Asp 
    50                  55                  60                  


Gln Lys Gly Val Thr Val Gln Ala Leu Ser Thr Val Pro Val Met Phe 
65                  70                  75                  80  


Ser Tyr Trp Ala Lys Pro Glu Asp Thr Leu Asn Leu Cys Gln Leu Leu 
                85                  90                  95      


Asn Asn Asp Leu Ala Ser Thr Val Val Ser Tyr Pro Arg Arg Phe Val 
            100                 105                 110         


Gly Leu Gly Thr Leu Pro Met Gln Ala Pro Glu Leu Ala Val Lys Glu 
        115                 120                 125             


Met Glu Arg Cys Val Lys Glu Leu Gly Phe Pro Gly Val Gln Ile Gly 
    130                 135                 140                 


Thr His Val Asn Glu Trp Asp Leu Asn Ala Gln Glu Leu Phe Pro Val 
145                 150                 155                 160 


Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser Leu Phe Val His Pro Trp 
                165                 170                 175     


Asp Met Gln Met Asp Gly Arg Met Ala Lys Tyr Trp Leu Pro Trp Leu 
            180                 185                 190         


Val Gly Met Pro Ala Glu Thr Thr Ile Ala Ile Cys Ser Met Ile Met 
        195                 200                 205             


Gly Gly Val Phe Glu Lys Phe Pro Lys Leu Lys Val Cys Phe Ala His 
    210                 215                 220                 


Gly Gly Gly Ala Phe Pro Phe Thr Val Gly Arg Ile Ser His Gly Phe 
225                 230                 235                 240 


Ser Met Arg Pro Asp Leu Cys Ala Gln Asp Asn Pro Met Asn Pro Lys 
                245                 250                 255     


Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala Leu Val His Asp Pro Leu 
            260                 265                 270         


Ser Leu Lys Leu Leu Thr Asp Val Ile Gly Lys Asp Lys Val Ile Leu 
        275                 280                 285             


Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu Leu Glu Pro Gly Lys Leu 
    290                 295                 300                 


Ile Glu Ser Met Glu Glu Phe Asp Glu Glu Thr Lys Asn Lys Leu Lys 
305                 310                 315                 320 


Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu Glu Arg Lys Gln Phe Glu 
                325                 330                 335     


<210>  124
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACO1__Homo_sapiens__NP_002188

<400>  124

Met Ser Asn Pro Phe Ala His Leu Ala Glu Pro Leu Asp Pro Val Gln 
1               5                   10                  15      


Pro Gly Lys Lys Phe Phe Asn Leu Asn Lys Leu Glu Asp Ser Arg Tyr 
            20                  25                  30          


Gly Arg Leu Pro Phe Ser Ile Arg Val Leu Leu Glu Ala Ala Ile Arg 
        35                  40                  45              


Asn Cys Asp Glu Phe Leu Val Lys Lys Gln Asp Ile Glu Asn Ile Leu 
    50                  55                  60                  


His Trp Asn Val Thr Gln His Lys Asn Ile Glu Val Pro Phe Lys Pro 
65                  70                  75                  80  


Ala Arg Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ala Val Val Asp 
                85                  90                  95      


Phe Ala Ala Met Arg Asp Ala Val Lys Lys Leu Gly Gly Asp Pro Glu 
            100                 105                 110         


Lys Ile Asn Pro Val Cys Pro Ala Asp Leu Val Ile Asp His Ser Ile 
        115                 120                 125             


Gln Val Asp Phe Asn Arg Arg Ala Asp Ser Leu Gln Lys Asn Gln Asp 
    130                 135                 140                 


Leu Glu Phe Glu Arg Asn Arg Glu Arg Phe Glu Phe Leu Lys Trp Gly 
145                 150                 155                 160 


Ser Gln Ala Phe His Asn Met Arg Ile Ile Pro Pro Gly Ser Gly Ile 
                165                 170                 175     


Ile His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val Phe Asp Gln 
            180                 185                 190         


Asp Gly Tyr Tyr Tyr Pro Asp Ser Leu Val Gly Thr Asp Ser His Thr 
        195                 200                 205             


Thr Met Ile Asp Gly Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile 
    210                 215                 220                 


Glu Ala Glu Ala Val Met Leu Gly Gln Pro Ile Ser Met Val Leu Pro 
225                 230                 235                 240 


Gln Val Ile Gly Tyr Arg Leu Met Gly Lys Pro His Pro Leu Val Thr 
                245                 250                 255     


Ser Thr Asp Ile Val Leu Thr Ile Thr Lys His Leu Arg Gln Val Gly 
            260                 265                 270         


Val Val Gly Lys Phe Val Glu Phe Phe Gly Pro Gly Val Ala Gln Leu 
        275                 280                 285             


Ser Ile Ala Asp Arg Ala Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly 
    290                 295                 300                 


Ala Thr Ala Ala Phe Phe Pro Val Asp Glu Val Ser Ile Thr Tyr Leu 
305                 310                 315                 320 


Val Gln Thr Gly Arg Asp Glu Glu Lys Leu Lys Tyr Ile Lys Lys Tyr 
                325                 330                 335     


Leu Gln Ala Val Gly Met Phe Arg Asp Phe Asn Asp Pro Ser Gln Asp 
            340                 345                 350         


Pro Asp Phe Thr Gln Val Val Glu Leu Asp Leu Lys Thr Val Val Pro 
        355                 360                 365             


Cys Cys Ser Gly Pro Lys Arg Pro Gln Asp Lys Val Ala Val Ser Asp 
    370                 375                 380                 


Met Lys Lys Asp Phe Glu Ser Cys Leu Gly Ala Lys Gln Gly Phe Lys 
385                 390                 395                 400 


Gly Phe Gln Val Ala Pro Glu His His Asn Asp His Lys Thr Phe Ile 
                405                 410                 415     


Tyr Asp Asn Thr Glu Phe Thr Leu Ala His Gly Ser Val Val Ile Ala 
            420                 425                 430         


Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Ser Val Met Leu Gly 
        435                 440                 445             


Ala Gly Leu Leu Ala Lys Lys Ala Val Asp Ala Gly Leu Asn Val Met 
    450                 455                 460                 


Pro Tyr Ile Lys Thr Ser Leu Ser Pro Gly Ser Gly Val Val Thr Tyr 
465                 470                 475                 480 


Tyr Leu Gln Glu Ser Gly Val Met Pro Tyr Leu Ser Gln Leu Gly Phe 
                485                 490                 495     


Asp Val Val Gly Tyr Gly Cys Met Thr Cys Ile Gly Asn Ser Gly Pro 
            500                 505                 510         


Leu Pro Glu Pro Val Val Glu Ala Ile Thr Gln Gly Asp Leu Val Ala 
        515                 520                 525             


Val Gly Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg Val His Pro 
    530                 535                 540                 


Asn Thr Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Ile Ala Tyr 
545                 550                 555                 560 


Ala Ile Ala Gly Thr Ile Arg Ile Asp Phe Glu Lys Glu Pro Leu Gly 
                565                 570                 575     


Val Asn Ala Lys Gly Gln Gln Val Phe Leu Lys Asp Ile Trp Pro Thr 
            580                 585                 590         


Arg Asp Glu Ile Gln Ala Val Glu Arg Gln Tyr Val Ile Pro Gly Met 
        595                 600                 605             


Phe Lys Glu Val Tyr Gln Lys Ile Glu Thr Val Asn Glu Ser Trp Asn 
    610                 615                 620                 


Ala Leu Ala Thr Pro Ser Asp Lys Leu Phe Phe Trp Asn Ser Lys Ser 
625                 630                 635                 640 


Thr Tyr Ile Lys Ser Pro Pro Phe Phe Glu Asn Leu Thr Leu Asp Leu 
                645                 650                 655     


Gln Pro Pro Lys Ser Ile Val Asp Ala Tyr Val Leu Leu Asn Leu Gly 
            660                 665                 670         


Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Asn Ile Ala Arg 
        675                 680                 685             


Asn Ser Pro Ala Ala Arg Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg 
    690                 695                 700                 


Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn Asp Ala Val Met Ala 
705                 710                 715                 720 


Arg Gly Thr Phe Ala Asn Ile Arg Leu Leu Asn Arg Phe Leu Asn Lys 
                725                 730                 735     


Gln Ala Pro Gln Thr Ile His Leu Pro Ser Gly Glu Ile Leu Asp Val 
            740                 745                 750         


Phe Asp Ala Ala Glu Arg Tyr Gln Gln Ala Gly Leu Pro Leu Ile Val 
        755                 760                 765             


Leu Ala Gly Lys Glu Tyr Gly Ala Gly Ser Ser Arg Asp Trp Ala Ala 
    770                 775                 780                 


Lys Gly Pro Phe Leu Leu Gly Ile Lys Ala Val Leu Ala Glu Ser Tyr 
785                 790                 795                 800 


Glu Arg Ile His Arg Ser Asn Leu Val Gly Met Gly Val Ile Pro Leu 
                805                 810                 815     


Glu Tyr Leu Pro Gly Glu Asn Ala Asp Ala Leu Gly Leu Thr Gly Gln 
            820                 825                 830         


Glu Arg Tyr Thr Ile Ile Ile Pro Glu Asn Leu Lys Pro Gln Met Lys 
        835                 840                 845             


Val Gln Val Lys Leu Asp Thr Gly Lys Thr Phe Gln Ala Val Met Arg 
    850                 855                 860                 


Phe Asp Thr Asp Val Glu Leu Thr Tyr Phe Leu Asn Gly Gly Ile Leu 
865                 870                 875                 880 


Asn Tyr Met Ile Arg Lys Met Ala Lys 
                885                 


<210>  125
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACO2__Homo_sapiens__NP_001089

<400>  125

Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly 
1               5                   10                  15      


Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val 
            20                  25                  30          


Ala Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu 
        35                  40                  45              


Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr 
    50                  55                  60                  


Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln 
65                  70                  75                  80  


Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val 
                85                  90                  95      


Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser 
            100                 105                 110         


Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His 
        115                 120                 125             


Leu Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys 
    130                 135                 140                 


Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys 
145                 150                 155                 160 


Tyr Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile 
                165                 170                 175     


Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp 
            180                 185                 190         


Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val 
        195                 200                 205             


Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu 
    210                 215                 220                 


Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly 
225                 230                 235                 240 


Trp Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr 
                245                 250                 255     


Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val 
            260                 265                 270         


Asp Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala 
        275                 280                 285             


Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys 
    290                 295                 300                 


Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp 
305                 310                 315                 320 


Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln 
                325                 330                 335     


Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro 
            340                 345                 350         


Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala 
        355                 360                 365             


Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser 
    370                 375                 380                 


Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala 
385                 390                 395                 400 


Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile 
                405                 410                 415     


Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr 
            420                 425                 430         


Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys 
        435                 440                 445             


Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu 
    450                 455                 460                 


Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn 
465                 470                 475                 480 


Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val 
                485                 490                 495     


Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp 
            500                 505                 510         


Tyr Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp 
        515                 520                 525             


Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr 
    530                 535                 540                 


Gln His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro 
545                 550                 555                 560 


Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly 
                565                 570                 575     


Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys 
            580                 585                 590         


Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly 
        595                 600                 605             


His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile 
    610                 615                 620                 


Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe 
625                 630                 635                 640 


Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg 
                645                 650                 655     


Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu 
            660                 665                 670         


His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr 
        675                 680                 685             


Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu 
    690                 695                 700                 


Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro 
705                 710                 715                 720 


Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys 
                725                 730                 735     


Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile 
            740                 745                 750         


Leu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala 
        755                 760                 765             


Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln 
    770                 775                 780 


<210>  126
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOT13__Homo_sapiens__NP_001153566

<400>  126

Met Val Arg Lys Ile Thr Leu Val Ser Ala Ala Pro Gly Lys Val Ile 
1               5                   10                  15      


Cys Glu Met Lys Val Glu Glu Glu His Thr Asn Ala Ile Gly Thr Leu 
            20                  25                  30          


His Gly Gly Leu Thr Ala Thr Leu Val Asp Asn Ile Ser Thr Met Ala 
        35                  40                  45              


Leu Leu Cys Thr Glu Arg Gly Ala Pro Gly Val Ser Val Asp Met Asn 
    50                  55                  60                  


Ile Thr Tyr Met Ser Pro Ala Lys Leu Gly Glu Asp Ile Val Ile Thr 
65                  70                  75                  80  


Ala His Val Leu Lys Gln Gly Lys Thr Leu Ala Phe Thr Ser Val Asp 
                85                  90                  95      


Leu Thr Asn Lys Ala Thr Gly Lys Leu Ile Ala Gln Gly Arg His Thr 
            100                 105                 110         


Lys His Leu Gly Asn 
        115         


<210>  127
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOT1__Homo_sapiens__NP_001032238

<400>  127

Met Ala Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp 
1               5                   10                  15      


Glu Pro Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val 
            20                  25                  30          


Thr Leu Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala 
        35                  40                  45              


His Ala Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg 
    50                  55                  60                  


Ala Pro Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu 
65                  70                  75                  80  


Leu Trp Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg 
                85                  90                  95      


Asp Val Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His 
            100                 105                 110         


Asp Pro Asp Pro Gly Arg Leu Leu Cys Arg Val Arg His Glu Arg Tyr 
        115                 120                 125             


Phe Leu Pro Pro Gly Val Arg Arg Glu Pro Val Arg Ala Gly Arg Val 
    130                 135                 140                 


Arg Gly Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile 
145                 150                 155                 160 


Val Asp Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser 
                165                 170                 175     


Leu Leu Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn 
            180                 185                 190         


Tyr Glu Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe 
        195                 200                 205             


Glu Glu Ala Val Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro 
    210                 215                 220                 


Gly Val Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser 
225                 230                 235                 240 


Met Ala Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly 
                245                 250                 255     


Ser Val Ala Asn Val Gly Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu 
            260                 265                 270         


Pro Pro Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly 
        275                 280                 285             


Tyr Ala Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp 
    290                 295                 300                 


Gln Lys Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe 
305                 310                 315                 320 


Leu Val Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn 
                325                 330                 335     


Glu Ala Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile 
            340                 345                 350         


Ile Cys Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro 
        355                 360                 365             


Leu Cys Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp 
    370                 375                 380                 


Gly Gly Glu Pro Arg Ala His Ala Met Ala Gln Val Asp Ala Trp Lys 
385                 390                 395                 400 


Gln Leu Gln Thr Phe Phe His Lys His Leu Gly Gly His Glu Gly Thr 
                405                 410                 415     


Ile Pro Ser Lys Val 
            420     


<210>  128
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOT2__Homo_sapiens__NP_006812

<400>  128

Met Ser Asn Lys Leu Leu Ser Pro His Pro His Ser Val Val Leu Arg 
1               5                   10                  15      


Ser Glu Phe Lys Met Ala Ser Ser Pro Ala Val Leu Arg Ala Ser Arg 
            20                  25                  30          


Leu Tyr Gln Trp Ser Leu Lys Ser Ser Ala Gln Phe Leu Gly Ser Pro 
        35                  40                  45              


Gln Leu Arg Gln Val Gly Gln Ile Ile Arg Val Pro Ala Arg Met Ala 
    50                  55                  60                  


Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp Glu Pro 
65                  70                  75                  80  


Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val Thr Leu 
                85                  90                  95      


Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala His Ala 
            100                 105                 110         


Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg Ala Pro 
        115                 120                 125             


Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu Leu Trp 
    130                 135                 140                 


Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg Asp Val 
145                 150                 155                 160 


Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His Asp Pro 
                165                 170                 175     


Asp Pro Gly Arg Leu Leu Cys Gln Thr Arg His Glu Arg Tyr Phe Leu 
            180                 185                 190         


Pro Pro Gly Val Arg Arg Glu Pro Val Arg Val Gly Arg Val Arg Gly 
        195                 200                 205             


Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile Val Asp 
    210                 215                 220                 


Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser Leu Leu 
225                 230                 235                 240 


Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn Tyr Glu 
                245                 250                 255     


Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe Glu Glu 
            260                 265                 270         


Ala Met Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro Gly Val 
        275                 280                 285             


Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser Met Ala 
    290                 295                 300                 


Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly Ser Val 
305                 310                 315                 320 


Ala Asn Val Gly Gly Thr Leu His Tyr Lys Gly Glu Thr Leu Pro Pro 
                325                 330                 335     


Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly Tyr Ala 
            340                 345                 350         


Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp Gln Lys 
        355                 360                 365             


Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe Leu Val 
    370                 375                 380                 


Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn Glu Ala 
385                 390                 395                 400 


Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile Ile Cys 
                405                 410                 415     


Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro Leu Cys 
            420                 425                 430         


Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp Gly Gly 
        435                 440                 445             


Glu Pro Arg Ala His Ala Met Ala Gln Val Asp Ala Trp Lys Gln Leu 
    450                 455                 460                 


Gln Thr Phe Phe His Lys His Leu Gly Gly His Glu Gly Thr Ile Pro 
465                 470                 475                 480 


Ser Lys Val 
            


<210>  129
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOT9__Homo_sapiens__NP_001028755

<400>  129

Met Arg Arg Ala Ala Leu Arg Leu Cys Ala Leu Gly Lys Gly Gln Leu 
1               5                   10                  15      


Thr Pro Gly Arg Gly Leu Thr Gln Gly Pro Gln Asn Pro Lys Lys Gln 
            20                  25                  30          


Gly Ile Phe His Ile His Glu Val Arg Asp Lys Leu Arg Glu Ile Val 
        35                  40                  45              


Gly Ala Ser Thr Asn Trp Arg Asp His Val Lys Ala Met Glu Glu Arg 
    50                  55                  60                  


Lys Leu Leu His Ser Phe Leu Ala Lys Ser Gln Asp Gly Leu Pro Pro 
65                  70                  75                  80  


Arg Arg Met Lys Asp Ser Tyr Ile Glu Val Leu Leu Pro Leu Gly Ser 
                85                  90                  95      


Glu Pro Glu Leu Arg Glu Lys Tyr Leu Thr Val Gln Asn Thr Val Arg 
            100                 105                 110         


Phe Gly Arg Ile Leu Glu Asp Leu Asp Ser Leu Gly Val Leu Ile Cys 
        115                 120                 125             


Tyr Met His Asn Lys Ile His Ser Ala Lys Met Ser Pro Leu Ser Ile 
    130                 135                 140                 


Val Thr Ala Leu Val Asp Lys Ile Asp Met Cys Lys Lys Ser Leu Ser 
145                 150                 155                 160 


Pro Glu Gln Asp Ile Lys Phe Ser Gly His Val Ser Trp Val Gly Lys 
                165                 170                 175     


Thr Ser Met Glu Val Lys Met Gln Met Phe Gln Leu His Gly Asp Glu 
            180                 185                 190         


Phe Cys Pro Val Leu Asp Ala Thr Phe Val Met Val Ala Arg Asp Ser 
        195                 200                 205             


Glu Asn Lys Gly Pro Ala Phe Val Asn Pro Leu Ile Pro Glu Ser Pro 
    210                 215                 220                 


Glu Glu Glu Glu Leu Phe Arg Gln Gly Glu Leu Asn Lys Gly Arg Arg 
225                 230                 235                 240 


Ile Ala Phe Ser Ser Thr Ser Leu Leu Lys Met Ala Pro Ser Ala Glu 
                245                 250                 255     


Glu Arg Thr Thr Ile His Glu Met Phe Leu Ser Thr Leu Asp Pro Lys 
            260                 265                 270         


Thr Ile Ser Phe Arg Ser Arg Val Leu Pro Ser Asn Ala Val Trp Met 
        275                 280                 285             


Glu Asn Ser Lys Leu Lys Ser Leu Glu Ile Cys His Pro Gln Glu Arg 
    290                 295                 300                 


Asn Ile Phe Asn Arg Ile Phe Gly Gly Phe Leu Met Arg Lys Ala Tyr 
305                 310                 315                 320 


Glu Leu Ala Trp Ala Thr Ala Cys Ser Phe Gly Gly Ser Arg Pro Phe 
                325                 330                 335     


Val Val Ala Val Asp Asp Ile Met Phe Gln Lys Pro Val Glu Val Gly 
            340                 345                 350         


Ser Leu Leu Phe Leu Ser Ser Gln Val Cys Phe Thr Gln Asn Asn Tyr 
        355                 360                 365             


Ile Gln Val Arg Val His Ser Glu Val Ala Ser Leu Gln Glu Lys Gln 
    370                 375                 380                 


His Thr Thr Thr Asn Val Phe His Phe Thr Phe Met Ser Glu Lys Glu 
385                 390                 395                 400 


Val Pro Leu Val Phe Pro Lys Thr Tyr Gly Glu Ser Met Leu Tyr Leu 
                405                 410                 415     


Asp Gly Gln Arg His Phe Asn Ser Met Ser Gly Pro Ala Thr Leu Arg 
            420                 425                 430         


Lys Asp Tyr Leu Val Glu Pro 
        435                 


<210>  130
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOX1__Homo_sapiens__NP_001171968

<400>  130

Met Ile Leu Asn Asp Pro Asp Phe Gln His Glu Asp Leu Asn Phe Leu 
1               5                   10                  15      


Thr Arg Ser Gln Arg Tyr Glu Val Ala Val Arg Lys Ser Ala Ile Met 
            20                  25                  30          


Val Lys Lys Met Arg Glu Phe Gly Ile Ala Asp Pro Asp Glu Ile Met 
        35                  40                  45              


Trp Phe Lys Asn Phe Val His Arg Gly Arg Pro Glu Pro Leu Asp Leu 
    50                  55                  60                  


His Leu Gly Met Phe Leu Pro Thr Leu Leu His Gln Ala Thr Ala Glu 
65                  70                  75                  80  


Gln Gln Glu Arg Phe Phe Met Pro Ala Trp Asn Leu Glu Ile Ile Gly 
                85                  90                  95      


Thr Tyr Ala Gln Thr Glu Met Gly His Gly Thr His Leu Arg Gly Leu 
            100                 105                 110         


Glu Thr Thr Ala Thr Tyr Asp Pro Glu Thr Gln Glu Phe Ile Leu Asn 
        115                 120                 125             


Ser Pro Thr Val Thr Ser Ile Lys Trp Trp Pro Gly Gly Leu Gly Lys 
    130                 135                 140                 


Thr Ser Asn His Ala Ile Val Leu Ala Gln Leu Ile Thr Lys Gly Lys 
145                 150                 155                 160 


Cys Tyr Gly Leu His Ala Phe Ile Val Pro Ile Arg Glu Ile Gly Thr 
                165                 170                 175     


His Lys Pro Leu Pro Gly Ile Thr Val Gly Asp Ile Gly Pro Lys Phe 
            180                 185                 190         


Gly Tyr Asp Glu Ile Asp Asn Gly Tyr Leu Lys Met Asp Asn His Arg 
        195                 200                 205             


Ile Pro Arg Glu Asn Met Leu Met Lys Tyr Ala Gln Val Lys Pro Asp 
    210                 215                 220                 


Gly Thr Tyr Val Lys Pro Leu Ser Asn Lys Leu Thr Tyr Gly Thr Met 
225                 230                 235                 240 


Val Phe Val Arg Ser Phe Leu Val Gly Glu Ala Ala Arg Ala Leu Ser 
                245                 250                 255     


Lys Ala Cys Thr Ile Ala Ile Arg Tyr Ser Ala Val Arg His Gln Ser 
            260                 265                 270         


Glu Ile Lys Pro Gly Glu Pro Glu Pro Gln Ile Leu Asp Phe Gln Thr 
        275                 280                 285             


Gln Gln Tyr Lys Leu Phe Pro Leu Leu Ala Thr Ala Tyr Ala Phe Gln 
    290                 295                 300                 


Phe Val Gly Ala Tyr Met Lys Glu Thr Tyr His Arg Ile Asn Glu Gly 
305                 310                 315                 320 


Ile Gly Gln Gly Asp Leu Ser Glu Leu Pro Glu Leu His Ala Leu Thr 
                325                 330                 335     


Ala Gly Leu Lys Ala Phe Thr Ser Trp Thr Ala Asn Thr Gly Ile Glu 
            340                 345                 350         


Ala Cys Arg Met Ala Cys Gly Gly His Gly Tyr Ser His Cys Ser Gly 
        355                 360                 365             


Leu Pro Asn Ile Tyr Val Asn Phe Thr Pro Ser Cys Thr Phe Glu Gly 
    370                 375                 380                 


Glu Asn Thr Val Met Met Leu Gln Thr Ala Arg Phe Leu Met Lys Ser 
385                 390                 395                 400 


Tyr Asp Gln Val His Ser Gly Lys Leu Val Cys Gly Met Val Ser Tyr 
                405                 410                 415     


Leu Asn Asp Leu Pro Ser Gln Arg Ile Gln Pro Gln Gln Val Ala Val 
            420                 425                 430         


Trp Pro Thr Met Val Asp Ile Asn Ser Pro Glu Ser Leu Thr Glu Ala 
        435                 440                 445             


Tyr Lys Leu Arg Ala Ala Arg Leu Val Glu Ile Ala Ala Lys Asn Leu 
    450                 455                 460                 


Gln Lys Glu Val Ile His Arg Lys Ser Lys Glu Val Ala Trp Asn Leu 
465                 470                 475                 480 


Thr Ser Val Asp Leu Val Arg Ala Ser Glu Ala His Cys His Tyr Val 
                485                 490                 495     


Val Val Lys Leu Phe Ser Glu Lys Leu Leu Lys Ile Gln Asp Lys Ala 
            500                 505                 510         


Ile Gln Ala Val Leu Arg Ser Leu Cys Leu Leu Tyr Ser Leu Tyr Gly 
        515                 520                 525             


Ile Ser Gln Asn Ala Gly Asp Phe Leu Gln Gly Ser Ile Met Thr Glu 
    530                 535                 540                 


Pro Gln Ile Thr Gln Val Asn Gln Arg Val Lys Glu Leu Leu Thr Leu 
545                 550                 555                 560 


Ile Arg Ser Asp Ala Val Ala Leu Val Asp Ala Phe Asp Phe Gln Asp 
                565                 570                 575     


Val Thr Leu Gly Ser Val Leu Gly Arg Tyr Asp Gly Asn Val Tyr Glu 
            580                 585                 590         


Asn Leu Phe Glu Trp Ala Lys Asn Ser Pro Leu Asn Lys Ala Glu Val 
        595                 600                 605             


His Glu Ser Tyr Lys His Leu Lys Ser Leu Gln Ser Lys Leu 
    610                 615                 620         


<210>  131
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOX2__Homo_sapiens__NP_003491

<400>  131

Met Gly Ser Pro Val His Arg Val Ser Leu Gly Asp Thr Trp Ser Arg 
1               5                   10                  15      


Gln Met His Pro Asp Ile Glu Ser Glu Arg Tyr Met Gln Ser Phe Asp 
            20                  25                  30          


Val Glu Arg Leu Thr Asn Ile Leu Asp Gly Gly Ala Gln Asn Thr Ala 
        35                  40                  45              


Leu Arg Arg Lys Val Glu Ser Ile Ile His Ser Tyr Pro Glu Phe Ser 
    50                  55                  60                  


Cys Lys Asp Asn Tyr Phe Met Thr Gln Asn Glu Arg Tyr Lys Ala Ala 
65                  70                  75                  80  


Met Arg Arg Ala Phe His Ile Arg Leu Ile Ala Arg Arg Leu Gly Trp 
                85                  90                  95      


Leu Glu Asp Gly Arg Glu Leu Gly Tyr Ala Tyr Arg Ala Leu Ser Gly 
            100                 105                 110         


Asp Val Ala Leu Asn Ile His Arg Val Phe Val Arg Ala Leu Arg Ser 
        115                 120                 125             


Leu Gly Ser Glu Glu Gln Ile Ala Lys Trp Asp Pro Leu Cys Lys Asn 
    130                 135                 140                 


Ile Gln Ile Ile Ala Thr Tyr Ala Gln Thr Glu Leu Gly His Gly Thr 
145                 150                 155                 160 


Tyr Leu Gln Gly Leu Glu Thr Glu Ala Thr Tyr Asp Ala Ala Thr Gln 
                165                 170                 175     


Glu Phe Val Ile His Ser Pro Thr Leu Thr Ala Thr Lys Trp Trp Pro 
            180                 185                 190         


Gly Asp Leu Gly Arg Ser Ala Thr His Ala Leu Val Gln Ala Gln Leu 
        195                 200                 205             


Ile Cys Ser Gly Ala Arg Arg Gly Met His Ala Phe Ile Val Pro Ile 
    210                 215                 220                 


Arg Ser Leu Gln Asp His Thr Pro Leu Pro Gly Ile Ile Ile Gly Asp 
225                 230                 235                 240 


Ile Gly Pro Lys Met Asp Phe Asp Gln Thr Asp Asn Gly Phe Leu Gln 
                245                 250                 255     


Leu Asn His Val Arg Val Pro Arg Glu Asn Met Leu Ser Arg Phe Ala 
            260                 265                 270         


Gln Val Leu Pro Asp Gly Thr Tyr Val Lys Leu Gly Thr Ala Gln Ser 
        275                 280                 285             


Asn Tyr Leu Pro Met Val Val Val Arg Val Glu Leu Leu Ser Gly Glu 
    290                 295                 300                 


Ile Leu Pro Ile Leu Gln Lys Ala Cys Val Ile Ala Met Arg Tyr Ser 
305                 310                 315                 320 


Val Ile Arg Arg Gln Ser Arg Leu Arg Pro Ser Asp Pro Glu Ala Lys 
                325                 330                 335     


Val Leu Asp Tyr Gln Thr Gln Gln Gln Lys Leu Phe Pro Gln Leu Ala 
            340                 345                 350         


Ile Ser Tyr Ala Phe His Phe Leu Ala Val Ser Leu Leu Glu Phe Phe 
        355                 360                 365             


Gln His Ser Tyr Thr Ala Ile Leu Asn Gln Asp Phe Ser Phe Leu Pro 
    370                 375                 380                 


Glu Leu His Ala Leu Ser Thr Gly Met Lys Ala Met Met Ser Glu Phe 
385                 390                 395                 400 


Cys Thr Gln Gly Ala Glu Met Cys Arg Arg Ala Cys Gly Gly His Gly 
                405                 410                 415     


Tyr Ser Lys Leu Ser Gly Leu Pro Ser Leu Val Thr Lys Leu Ser Ala 
            420                 425                 430         


Ser Cys Thr Tyr Glu Gly Glu Asn Thr Val Leu Tyr Leu Gln Val Ala 
        435                 440                 445             


Arg Phe Leu Val Lys Ser Tyr Leu Gln Thr Gln Met Ser Pro Gly Ser 
    450                 455                 460                 


Thr Pro Gln Arg Ser Leu Ser Pro Ser Val Ala Tyr Leu Thr Ala Pro 
465                 470                 475                 480 


Asp Leu Ala Arg Cys Pro Ala Gln Arg Ala Ala Asp Phe Leu Cys Pro 
                485                 490                 495     


Glu Leu Tyr Thr Thr Ala Trp Ala His Val Ala Val Arg Leu Ile Lys 
            500                 505                 510         


Asp Ser Val Gln His Leu Gln Thr Leu Thr Gln Ser Gly Ala Asp Gln 
        515                 520                 525             


His Glu Ala Trp Asn Gln Thr Thr Val Ile His Leu Gln Ala Ala Lys 
    530                 535                 540                 


Val His Cys Tyr Tyr Val Thr Val Lys Gly Phe Thr Glu Ala Leu Glu 
545                 550                 555                 560 


Lys Leu Glu Asn Glu Pro Ala Ile Gln Gln Val Leu Lys Arg Leu Cys 
                565                 570                 575     


Asp Leu His Ala Ile His Gly Ile Leu Thr Asn Ser Gly Asp Phe Leu 
            580                 585                 590         


His Asp Ala Phe Leu Ser Gly Ala Gln Val Asp Met Ala Arg Thr Ala 
        595                 600                 605             


Tyr Leu Asp Leu Leu Arg Leu Ile Arg Lys Asp Ala Ile Leu Leu Thr 
    610                 615                 620                 


Asp Ala Phe Asp Phe Thr Asp Gln Cys Leu Asn Ser Ala Leu Gly Cys 
625                 630                 635                 640 


Tyr Asp Gly Asn Val Tyr Glu Arg Leu Phe Gln Trp Ala Gln Lys Ser 
                645                 650                 655     


Pro Thr Asn Thr Gln Glu Asn Pro Ala Tyr Glu Glu Tyr Ile Arg Pro 
            660                 665                 670         


Leu Leu Gln Ser Trp Arg Ser Lys Leu 
        675                 680     


<210>  132
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOX3__Homo_sapiens__NP_001095137

<400>  132

Met Ala Ser Thr Val Glu Gly Gly Asp Thr Ala Leu Leu Pro Glu Phe 
1               5                   10                  15      


Pro Arg Gly Pro Leu Asp Ala Tyr Arg Ala Arg Ala Ser Phe Ser Trp 
            20                  25                  30          


Lys Glu Leu Ala Leu Phe Thr Glu Gly Glu Gly Met Leu Arg Phe Lys 
        35                  40                  45              


Lys Thr Ile Phe Ser Ala Leu Glu Asn Asp Pro Leu Phe Ala Arg Ser 
    50                  55                  60                  


Pro Gly Ala Asp Leu Ser Leu Glu Lys Tyr Arg Glu Leu Asn Phe Leu 
65                  70                  75                  80  


Arg Cys Lys Arg Ile Phe Glu Tyr Asp Phe Leu Ser Val Glu Asp Met 
                85                  90                  95      


Phe Lys Ser Pro Leu Lys Val Pro Ala Leu Ile Gln Cys Leu Gly Met 
            100                 105                 110         


Tyr Asp Ser Ser Leu Ala Ala Lys Tyr Leu Leu His Ser Leu Val Phe 
        115                 120                 125             


Gly Ser Ala Val Tyr Ser Ser Gly Ser Glu Arg His Leu Thr Tyr Ile 
    130                 135                 140                 


Gln Lys Ile Phe Arg Met Glu Ile Phe Gly Cys Phe Ala Leu Thr Glu 
145                 150                 155                 160 


Leu Ser His Gly Ser Asn Thr Lys Ala Ile Arg Thr Thr Ala His Tyr 
                165                 170                 175     


Asp Pro Ala Thr Glu Glu Phe Ile Ile His Ser Pro Asp Phe Glu Ala 
            180                 185                 190         


Ala Lys Phe Trp Val Gly Asn Met Gly Lys Thr Ala Thr His Ala Val 
        195                 200                 205             


Val Phe Ala Lys Leu Cys Val Pro Gly Asp Gln Cys His Gly Leu His 
    210                 215                 220                 


Pro Phe Ile Val Gln Ile Arg Asp Pro Lys Thr Leu Leu Pro Met Pro 
225                 230                 235                 240 


Gly Val Met Val Gly Asp Ile Gly Lys Lys Leu Gly Gln Asn Gly Leu 
                245                 250                 255     


Asp Asn Gly Phe Ala Met Phe His Lys Val Arg Val Pro Arg Gln Ser 
            260                 265                 270         


Leu Leu Asn Arg Met Gly Asp Val Thr Pro Glu Gly Thr Tyr Val Ser 
        275                 280                 285             


Pro Phe Lys Asp Val Arg Gln Arg Phe Gly Ala Ser Leu Gly Ser Leu 
    290                 295                 300                 


Ser Ser Gly Arg Val Ser Ile Val Ser Leu Ala Ile Leu Asn Leu Lys 
305                 310                 315                 320 


Leu Ala Val Ala Ile Ala Leu Arg Phe Ser Ala Thr Arg Arg Gln Phe 
                325                 330                 335     


Gly Pro Thr Glu Glu Glu Glu Ile Pro Val Leu Glu Tyr Pro Met Gln 
            340                 345                 350         


Gln Trp Arg Leu Leu Pro Tyr Leu Ala Ala Val Tyr Ala Leu Asp His 
        355                 360                 365             


Phe Ser Lys Ser Leu Phe Leu Asp Leu Val Glu Leu Gln Arg Gly Leu 
    370                 375                 380                 


Ala Ser Gly Asp Arg Ser Ala Arg Gln Ala Glu Leu Gly Arg Glu Ile 
385                 390                 395                 400 


His Ala Leu Ala Ser Ala Ser Lys Pro Leu Ala Ser Trp Thr Thr Gln 
                405                 410                 415     


Gln Gly Ile Gln Glu Cys Arg Glu Ala Cys Gly Gly His Gly Tyr Leu 
            420                 425                 430         


Ala Met Asn Arg Leu Gly Val Leu Arg Asp Asp Asn Asp Pro Asn Cys 
        435                 440                 445             


Thr Tyr Glu Gly Asp Asn Asn Ile Leu Leu Gln Gln Thr Ser Asn Tyr 
    450                 455                 460                 


Leu Leu Gly Leu Leu Ala His Gln Val His Asp Gly Ala Cys Phe Arg 
465                 470                 475                 480 


Ser Pro Leu Lys Ser Val Asp Phe Leu Asp Ala Tyr Pro Gly Ile Leu 
                485                 490                 495     


Asp Gln Lys Phe Glu Val Ser Ser Val Ala Asp Cys Leu Asp Ser Ala 
            500                 505                 510         


Val Ala Leu Ala Ala Tyr Lys Trp Leu Val Cys Tyr Leu Leu Arg Glu 
        515                 520                 525             


Thr Tyr Gln Lys Leu Asn Gln Glu Lys Arg Ser Gly Ser Ser Asp Phe 
    530                 535                 540                 


Glu Ala Arg Asn Lys Cys Gln Val Ser His Gly Arg Pro Leu Ala Leu 
545                 550                 555                 560 


Ala Phe Val Glu Leu Thr Val Val Gln Arg Phe His Glu His Val His 
                565                 570                 575     


Gln Pro Ser Val Pro Pro Ser Leu Arg Ala Val Leu Gly Arg Leu Ser 
            580                 585                 590         


Ala Leu Tyr Ala Leu Trp Ser Leu Ser Arg His Ala Ala Leu Leu Tyr 
        595                 600                 605             


Arg Ala Glu Arg Arg Cys Ser Cys Pro Gly Arg Arg Asp Arg Ser Ser 
    610                 615                 620                 


<210>  133
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACOXL__Homo_sapiens__NP_001136279

<400>  133

Met Arg Ala Leu Thr Val Gln Arg Val Lys Phe Ala Met Asp Leu Pro 
1               5                   10                  15      


Leu Leu Lys Arg Ala Gly Gln Asp Leu Ala Glu Lys Thr Lys Asn Phe 
            20                  25                  30          


Val Ser Arg Ser Leu Val Ile Gly Glu Val Leu Ser Met Ala Asp Met 
        35                  40                  45              


Ala Thr Gly Val Lys Cys Gly Ile Ile Tyr Trp Leu Phe Gly Gly Ala 
    50                  55                  60                  


Ile Arg Asn Leu Gly Ser Pro Glu His Val Thr Lys Trp Phe Gln Pro 
65                  70                  75                  80  


Leu Gln Glu Gln Lys Tyr Thr Gly Met Phe Ala Met Thr Glu Arg Gly 
                85                  90                  95      


His Gly Ser Asn Ala Arg Gly Ile Gln Thr Glu Ala Thr Phe Asp Leu 
            100                 105                 110         


Ser Ala Gln Glu Phe Val Ile Asp Thr Pro Cys Glu Asn Ala Glu Lys 
        115                 120                 125             


Met Tyr Ile Gly Asn Ala Met Tyr Gly Asn Tyr Ala Ala Val Phe Ala 
    130                 135                 140                 


Gln Leu Ile Ile Asp Gly Arg Ser Gln Gly Pro His Cys Phe Ile Val 
145                 150                 155                 160 


Pro Val Arg Asp Glu Asn Gly Ser Leu Tyr Pro Gly Val Thr Ala Ile 
                165                 170                 175     


Asp Met Met Tyr Lys Glu Gly Leu His Gly Val Asp Asn Gly Ile Leu 
            180                 185                 190         


Ile Phe Asp Lys Val Arg Ile Pro Arg Glu Asn Leu Leu Asp Lys Phe 
        195                 200                 205             


Gly Ser Val Ala Pro Asp Gly Gln Tyr His Ser Pro Ile Arg Asn Lys 
    210                 215                 220                 


Ser Ala Arg Phe Asn Ala Met Leu Ala Ala Leu Thr Pro Ser Arg Leu 
225                 230                 235                 240 


Ala Val Ala Phe Gln Ala Met Gly Ala Met Lys Leu Gly Leu Thr Ile 
                245                 250                 255     


Ala Ile Arg Tyr Ser His Ser Arg Arg Gln Phe Gly Pro Lys Thr Lys 
            260                 265                 270         


Glu Glu Val Lys Ile Ile Glu His Gln Thr Gln Thr Leu Arg Leu Met 
        275                 280                 285             


Pro His Leu Ala Thr Ala Leu Ala Leu Thr Phe Val Ser Arg Tyr Ala 
    290                 295                 300                 


Gly Ala Leu Leu Asp Glu Asp Val Phe Gln Gly Lys Glu Leu Val Asn 
305                 310                 315                 320 


Ser Arg Ser Leu Gln Ala Leu Val Ala Gly Leu Lys Ala Tyr Ser Thr 
                325                 330                 335     


Trp Glu Asn Ile Arg Cys Leu Gln Asp Cys Arg Glu Cys Thr Gly Gly 
            340                 345                 350         


Met Val Val Gly Arg Glu Leu Leu Ala Gln Tyr Thr Lys Gln Tyr Glu 
        355                 360                 365             


Glu Lys Pro Leu Phe Gly Leu Leu Gln Asn Trp Ala Glu Ser Val Gly 
    370                 375                 380                 


Asp Lys Leu Arg Thr Ser Phe Leu Ala Phe Asn Met Asp Thr Val Asp 
385                 390                 395                 400 


Asp Leu Ala Phe Leu Leu Lys Ala Val Lys Phe Arg Glu Arg Val Leu 
                405                 410                 415     


Gln Arg Gly Leu Val Ala Arg Ile Tyr Tyr Lys Val Lys Thr Lys Lys 
            420                 425                 430         


Glu Asp Phe Phe His Ala Trp Asn Ser Cys Leu His His Val Ala Ser 
        435                 440                 445             


Leu Ser Leu Ala His Thr His Arg Val Thr Leu Glu Gln Phe Ser Leu 
    450                 455                 460                 


Ala Val Lys Ser Cys Pro Asp Gln Glu Asp Gln Thr Leu Leu Met Lys 
465                 470                 475                 480 


Phe Cys Leu Leu Tyr Gly Thr Lys Leu Val Phe Gln Glu Arg Ala Trp 
                485                 490                 495     


Tyr Leu Glu His Lys Tyr Leu Thr Pro Met Ala Ser Thr Arg Ile Arg 
            500                 505                 510         


Asn Gln Leu Leu Asp Leu Cys Asp Ser Val Lys Asp Asp Ala Arg Arg 
        515                 520                 525             


Val Ile Ser Thr Phe Asn Ile Pro His Thr Tyr Leu His Ala Pro Ile 
    530                 535                 540                 


Ala Gly Ile Ser Asn Pro Arg Ala Ala Trp Ala Phe Tyr Pro Ala Pro 
545                 550                 555                 560 


Leu Gln Pro Arg Pro Arg Glu Glu Ala Arg Ser Arg Arg Pro Lys Leu 
                565                 570                 575     


Gly Ala Lys Leu 
            580 


<210>  134
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP1__Homo_sapiens__NP_001035739

<400>  134

Met Ala Glu Gln Ala Thr Lys Ser Val Leu Phe Val Cys Leu Gly Asn 
1               5                   10                  15      


Ile Cys Arg Ser Pro Ile Ala Glu Ala Val Phe Arg Lys Leu Val Thr 
            20                  25                  30          


Asp Gln Asn Ile Ser Glu Asn Trp Arg Val Asp Ser Ala Ala Thr Ser 
        35                  40                  45              


Gly Tyr Glu Ile Gly Asn Pro Pro Asp Tyr Arg Gly Gln Ser Cys Met 
    50                  55                  60                  


Lys Arg His Gly Ile Pro Met Ser His Val Ala Arg Gln Val Pro Ser 
65                  70                  75                  80  


Leu Asp Leu Lys Leu Cys Val Leu Cys Phe Ser Gly Ser Leu Thr Ala 
                85                  90                  95      


Val Leu Phe Leu Thr Gly Thr Trp Ala Gly Pro Gln Thr Gln Glu Leu 
            100                 105                 110         


<210>  135
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP2__Homo_sapiens__NP_001289419

<400>  135

Met Ala Gly Lys Arg Ser Gly Trp Ser Arg Ala Ala Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Gly Val Asn Leu Val Val Met Pro Pro Thr Arg Ala Arg Ser 
            20                  25                  30          


Leu Arg Phe Val Thr Leu Glu Gly Met Leu Gln His Trp Glu Leu Gly 
        35                  40                  45              


Gln Ala Leu Arg Gln Arg Tyr His Gly Phe Leu Asn Thr Ser Tyr His 
    50                  55                  60                  


Arg Gln Glu Val Tyr Val Arg Ser Thr Asp Phe Asp Arg Thr Leu Met 
65                  70                  75                  80  


Ser Ala Glu Ala Asn Leu Ala Gly Leu Phe Pro Pro Asn Gly Met Gln 
                85                  90                  95      


Arg Phe Asn Pro Asn Ile Ser Trp Gln Pro Ile Pro Val His Thr Val 
            100                 105                 110         


Pro Ile Thr Glu Asp Arg Leu Leu Lys Phe Pro Leu Gly Pro Cys Pro 
        115                 120                 125             


Arg Tyr Glu Gln Leu Gln Asn Glu Thr Arg Gln Thr Pro Glu Tyr Gln 
    130                 135                 140                 


Asn Glu Ser Ser Arg Asn Ala Gln Phe Leu Asp Met Val Ala Asn Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Asp Leu Thr Leu Glu Thr Val Trp Asn Val Tyr Asp 
                165                 170                 175     


Thr Leu Phe Cys Glu Gln Thr His Gly Leu Arg Leu Pro Pro Trp Ala 
            180                 185                 190         


Ser Pro Gln Thr Met Gln Arg Leu Ser Arg Leu Lys Asp Phe Ser Phe 
        195                 200                 205             


Arg Phe Leu Phe Gly Ile Tyr Gln Gln Ala Glu Lys Ala Arg Leu Gln 
    210                 215                 220                 


Gly Gly Val Leu Leu Ala Gln Ile Arg Lys Asn Leu Thr Leu Met Ala 
225                 230                 235                 240 


Thr Thr Ser Gln Leu Pro Lys Leu Leu Val Tyr Ser Ala His Asp Thr 
                245                 250                 255     


Thr Leu Val Ala Leu Gln Met Ala Leu Asp Val Tyr Asn Gly Glu Gln 
            260                 265                 270         


Ala Pro Tyr Ala Ser Cys His Ile Phe Glu Leu Tyr Gln Glu Asp Ser 
        275                 280                 285             


Gly Asn Phe Ser Val Glu Met Tyr Phe Arg Asn Glu Ser Asp Lys Ala 
    290                 295                 300                 


Pro Trp Pro Leu Ser Leu Pro Gly Cys Pro His Arg Cys Pro Leu Gln 
305                 310                 315                 320 


Asp Phe Leu Arg Leu Thr Glu Pro Val Val Pro Lys Asp Trp Gln Gln 
                325                 330                 335     


Glu Cys Gln Leu Ala Ser Gly Pro Ala Asp Thr Glu Val Ile Val Ala 
            340                 345                 350         


Leu Ala Val Cys Gly Ser Ile Leu Phe Leu Leu Ile Val Leu Leu Leu 
        355                 360                 365             


Thr Val Leu Phe Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val 
    370                 375                 380                 


Ala Asp Gly Glu Asp His Ala 
385                 390     


<210>  136
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP5__Homo_sapiens__NP_001104506

<400>  136

Met Asp Met Trp Thr Ala Leu Leu Ile Leu Gln Ala Leu Leu Leu Pro 
1               5                   10                  15      


Ser Leu Ala Asp Gly Ala Thr Pro Ala Leu Arg Phe Val Ala Val Gly 
            20                  25                  30          


Asp Trp Gly Gly Val Pro Asn Ala Pro Phe His Thr Ala Arg Glu Met 
        35                  40                  45              


Ala Asn Ala Lys Glu Ile Ala Arg Thr Val Gln Ile Leu Gly Ala Asp 
    50                  55                  60                  


Phe Ile Leu Ser Leu Gly Asp Asn Phe Tyr Phe Thr Gly Val Gln Asp 
65                  70                  75                  80  


Ile Asn Asp Lys Arg Phe Gln Glu Thr Phe Glu Asp Val Phe Ser Asp 
                85                  90                  95      


Arg Ser Leu Arg Lys Val Pro Trp Tyr Val Leu Ala Gly Asn His Asp 
            100                 105                 110         


His Leu Gly Asn Val Ser Ala Gln Ile Ala Tyr Ser Lys Ile Ser Lys 
        115                 120                 125             


Arg Trp Asn Phe Pro Ser Pro Phe Tyr Arg Leu His Phe Lys Ile Pro 
    130                 135                 140                 


Gln Thr Asn Val Ser Val Ala Ile Phe Met Leu Asp Thr Val Thr Leu 
145                 150                 155                 160 


Cys Gly Asn Ser Asp Asp Phe Leu Ser Gln Gln Pro Glu Arg Pro Arg 
                165                 170                 175     


Asp Val Lys Leu Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu 
            180                 185                 190         


Ala Ala Ala Arg Glu Asp Tyr Val Leu Val Ala Gly His Tyr Pro Val 
        195                 200                 205             


Trp Ser Ile Ala Glu His Gly Pro Thr His Cys Leu Val Lys Gln Leu 
    210                 215                 220                 


Arg Pro Leu Leu Ala Thr Tyr Gly Val Thr Ala Tyr Leu Cys Gly His 
225                 230                 235                 240 


Asp His Asn Leu Gln Tyr Leu Gln Asp Glu Asn Gly Val Gly Tyr Val 
                245                 250                 255     


Leu Ser Gly Ala Gly Asn Phe Met Asp Pro Ser Lys Arg His Gln Arg 
            260                 265                 270         


Lys Val Pro Asn Gly Tyr Leu Arg Phe His Tyr Gly Thr Glu Asp Ser 
        275                 280                 285             


Leu Gly Gly Phe Ala Tyr Val Glu Ile Ser Ser Lys Glu Met Thr Val 
    290                 295                 300                 


Thr Tyr Ile Glu Ala Ser Gly Lys Ser Leu Phe Lys Thr Arg Leu Pro 
305                 310                 315                 320 


Arg Arg Ala Arg Pro 
                325 


<210>  137
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACP6__Homo_sapiens__XP_011507903

<400>  137

Met Ile Thr Gly Val Phe Ser Met Arg Leu Trp Thr Pro Val Gly Val 
1               5                   10                  15      


Leu Thr Ser Leu Ala Tyr Cys Leu His Gln Arg Arg Val Ala Leu Ala 
            20                  25                  30          


Glu Leu Gln Glu Ala Asp Gly Gln Cys Pro Val Asp Arg Ser Leu Leu 
        35                  40                  45              


Lys Leu Lys Met Val Gln Val Val Phe Arg His Gly Ala Arg Ser Pro 
    50                  55                  60                  


Leu Lys Pro Leu Pro Leu Glu Glu Gln Val Glu Trp Asn Pro Gln Leu 
65                  70                  75                  80  


Leu Glu Val Pro Pro Gln Thr Gln Phe Asp Tyr Thr Val Thr Asn Leu 
                85                  90                  95      


Ala Gly Gly Pro Lys Pro Tyr Ser Pro Tyr Asp Ser Gln Tyr His Glu 
            100                 105                 110         


Thr Thr Leu Lys Gly Gly Met Phe Ala Gly Gln Leu Thr Lys Val Gly 
        115                 120                 125             


Met Gln Gln Met Phe Ala Leu Gly Glu Arg Leu Arg Lys Asn Tyr Val 
    130                 135                 140                 


Glu Asp Ile Pro Phe Leu Ser Pro Thr Phe Asn Pro Gln Glu Val Phe 
145                 150                 155                 160 


Ile Arg Ser Thr Asn Ile Phe Arg Asn Leu Glu Ser Thr Arg Cys Leu 
                165                 170                 175     


Leu Ala Gly Leu Phe Gln Cys Gln Lys Glu Gly Pro Ile Ile Ile His 
            180                 185                 190         


Thr Asp Glu Ala Asp Ser Glu Val Leu Tyr Pro Asn Tyr Gln Ser Cys 
        195                 200                 205             


Trp Ser Leu Arg Gln Arg Thr Arg Gly Arg Arg Gln Thr Ala Ser Leu 
    210                 215                 220                 


Gln Pro Gly Ile Ser Glu Asp Leu Lys Lys Val Lys Asp Arg Met Gly 
225                 230                 235                 240 


Ile Asp Ser Ser Asp Lys Val Asp Phe Phe Ile Leu Leu Asp Asn Val 
                245                 250                 255     


Ala Ala Glu Gln Ala His Asn Leu Pro Ser Cys Pro Met Leu Lys Arg 
            260                 265                 270         


Phe Ala Arg Met Ile Glu Gln Arg Ala Val Asp Thr Ser Leu Tyr Ile 
        275                 280                 285             


Leu Pro Lys Glu Asp Arg Glu Ser Leu Gln Met Ala Val Gly Pro Phe 
    290                 295                 300                 


Leu His Ile Leu Glu Ser Asn Leu Leu Lys Ala Met Asp Ser Ala Thr 
305                 310                 315                 320 


Ala Pro Asp Lys Ile Arg Lys Leu Tyr Leu Tyr Ala Ala His Asp Val 
                325                 330                 335     


Thr Phe Ile Pro Leu Leu Met Thr Leu Gly Ile Phe Asp His Lys Trp 
            340                 345                 350         


Pro Pro Phe Ala Val Asp Leu Thr Met Glu Leu Tyr Gln His Leu Glu 
        355                 360                 365             


Ser Lys Glu Trp Phe Val Gln Leu Tyr Tyr His Gly Lys Asp Leu Gln 
    370                 375                 380                 


Val Ala Ser Ile Thr Gly Met Lys Lys Ile Leu Gly Leu Phe Gln Pro 
385                 390                 395                 400 


His 
    


<210>  138
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACPP__Homo_sapiens__NP_001090

<400>  138

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  139
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACRBP__Homo_sapiens__NP_115878

<400>  139

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Gly Ala Val Cys Ser Asn Leu Pro Tyr 
                85                  90                  95      


Ala Ser Trp Phe Glu Ser Phe Cys Gln Phe Thr His Tyr Arg Cys Ser 
            100                 105                 110         


Asn His Val Tyr Tyr Ala Lys Arg Val Leu Cys Ser Gln Pro Val Ser 
        115                 120                 125             


Ile Leu Ser Pro Asn Thr Leu Lys Glu Ile Glu Ala Ser Ala Glu Val 
    130                 135                 140                 


Ser Pro Thr Thr Met Thr Ser Pro Ile Ser Pro His Phe Thr Val Thr 
145                 150                 155                 160 


Glu Arg Gln Thr Phe Gln Pro Trp Pro Glu Arg Leu Ser Asn Asn Val 
                165                 170                 175     


Glu Glu Leu Leu Gln Ser Ser Leu Ser Leu Gly Gly Gln Glu Gln Ala 
            180                 185                 190         


Pro Glu His Lys Gln Glu Gln Gly Val Glu His Arg Gln Glu Pro Thr 
        195                 200                 205             


Gln Glu His Lys Gln Glu Glu Gly Gln Lys Gln Glu Glu Gln Glu Glu 
    210                 215                 220                 


Glu Gln Glu Glu Glu Gly Lys Gln Glu Glu Gly Gln Gly Thr Lys Glu 
225                 230                 235                 240 


Gly Arg Glu Ala Val Ser Gln Leu Gln Thr Asp Ser Glu Pro Lys Phe 
                245                 250                 255     


His Ser Glu Ser Leu Ser Ser Asn Pro Ser Ser Phe Ala Pro Arg Val 
            260                 265                 270         


Arg Glu Val Glu Ser Thr Pro Met Ile Met Glu Asn Ile Gln Glu Leu 
        275                 280                 285             


Ile Arg Ser Ala Gln Glu Ile Asp Glu Met Asn Glu Ile Tyr Asp Glu 
    290                 295                 300                 


Asn Ser Tyr Trp Arg Asn Gln Asn Pro Gly Ser Leu Leu Gln Leu Pro 
305                 310                 315                 320 


His Thr Glu Ala Leu Leu Val Leu Cys Tyr Ser Ile Val Glu Asn Thr 
                325                 330                 335     


Cys Ile Ile Thr Pro Thr Ala Lys Ala Trp Lys Tyr Met Glu Glu Glu 
            340                 345                 350         


Ile Leu Gly Phe Gly Lys Ser Val Cys Asp Ser Leu Gly Arg Arg His 
        355                 360                 365             


Met Ser Thr Cys Ala Leu Cys Asp Phe Cys Ser Leu Lys Leu Glu Gln 
    370                 375                 380                 


Cys His Ser Glu Ala Ser Leu Gln Arg Gln Gln Cys Asp Thr Ser His 
385                 390                 395                 400 


Lys Thr Pro Phe Val Ser Pro Leu Leu Ala Ser Gln Ser Leu Ser Ile 
                405                 410                 415     


Gly Asn Gln Val Gly Ser Pro Glu Ser Gly Arg Phe Tyr Gly Leu Asp 
            420                 425                 430         


Leu Tyr Gly Gly Leu His Met Asp Phe Trp Cys Ala Arg Leu Ala Thr 
        435                 440                 445             


Lys Gly Cys Glu Asp Val Arg Val Ser Gly Trp Leu Gln Thr Glu Phe 
    450                 455                 460                 


Leu Ser Phe Gln Asp Gly Asp Phe Pro Thr Lys Ile Cys Asp Thr Asp 
465                 470                 475                 480 


Tyr Ile Gln Tyr Pro Asn Tyr Cys Ser Phe Lys Ser Gln Gln Cys Leu 
                485                 490                 495     


Met Arg Asn Arg Asn Arg Lys Val Ser Arg Met Arg Cys Leu Gln Asn 
            500                 505                 510         


Glu Thr Tyr Ser Ala Leu Ser Pro Gly Lys Ser Glu Asp Val Val Leu 
        515                 520                 525             


Arg Trp Ser Gln Glu Phe Ser Thr Leu Thr Leu Gly Gln Phe Gly 
    530                 535                 540             


<210>  140
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACRC__Homo_sapiens__XP_011529367

<400>  140

Met Asp Gly Cys Lys Lys Glu Leu Pro Arg Leu Gln Glu Pro Glu Glu 
1               5                   10                  15      


Asp Glu Asp Cys Tyr Ile Leu Asn Val Gln Ser Ser Ser Asp Asp Thr 
            20                  25                  30          


Ser Gly Ser Ser Val Ala Arg Arg Ala Pro Lys Arg Gln Ala Ser Cys 
        35                  40                  45              


Ile Leu Asn Val Gln Ser Arg Ser Gly Asp Thr Ser Gly Ser Ser Val 
    50                  55                  60                  


Ala Arg Arg Ala Pro Lys Arg Gln Ala Ser Ser Val Val Val Ile Asp 
65                  70                  75                  80  


Ser Asp Ser Asp Glu Glu Cys His Thr His Glu Glu Lys Lys Ala Lys 
                85                  90                  95      


Leu Leu Glu Ile Asn Ser Asp Asp Glu Ser Pro Glu Cys Cys His Val 
            100                 105                 110         


Lys Pro Ala Ile Gln Glu Pro Pro Ile Val Ile Ser Asp Asp Asp Asn 
        115                 120                 125             


Asp Asp Asp Asn Gly Asn Asp Leu Glu Val Pro Asp Asp Asn Ser Asp 
    130                 135                 140                 


Asp Ser Glu Ala Pro Asp Asp Asn Ser Asp Asp Ser Glu Ala Pro Asp 
145                 150                 155                 160 


Asp Asn Ser Asp Asp Ser Glu Ala Pro Asp Asp Asn Ser Asp Asp Ser 
                165                 170                 175     


Glu Ala Pro Asp Asp Asn Ser Asp Asp Ser Asp Val Pro Asp Asp Asn 
            180                 185                 190         


Ser Asp Asp Ser Ser Asp Asp Asn Ser Asp Asp Ser Ser Asp Asp Asn 
        195                 200                 205             


Ser Asp Asp Ser Asp Val Pro Asp Asp Lys Ser Asp Asp Ser Asp Val 
    210                 215                 220                 


Pro Asp Asp Ser Ser Asp Asp Ser Asp Val Pro Asp Asp Ser Ser Asp 
225                 230                 235                 240 


Asp Ser Glu Ala Pro Asp Asp Ser Ser Asp Asp Ser Glu Ala Pro Asp 
                245                 250                 255     


Asp Ser Ser Asp Asp Ser Glu Ala Pro Asp Asp Ser Ser Asp Asp Ser 
            260                 265                 270         


Glu Ala Pro Asp Asp Ser Ser Asp Asp Ser Glu Ala Ser Asp Asp Ser 
        275                 280                 285             


Ser Asp Asp Ser Glu Ala Ser Asp Asp Ser Ser Asp Asp Ser Glu Ala 
    290                 295                 300                 


Pro Asp Asp Lys Ser Asp Asp Ser Asp Val Pro Glu Asp Lys Ser Asp 
305                 310                 315                 320 


Asp Ser Asp Val Pro Asp Asp Asn Ser Asp Asp Leu Glu Val Pro Val 
                325                 330                 335     


Pro Ala Glu Asp Leu Cys Asn Glu Gly Gln Ile Ala Ser Asp Glu Glu 
            340                 345                 350         


Glu Leu Val Glu Ala Ala Ala Ala Val Ser Gln His Asp Ser Ser Asp 
        355                 360                 365             


Asp Ala Gly Glu Gln Asp Leu Gly Glu Asn Leu Ser Lys Pro Pro Ser 
    370                 375                 380                 


Asp Pro Glu Ala Asn Pro Glu Val Ser Glu Arg Lys Leu Pro Thr Glu 
385                 390                 395                 400 


Glu Glu Pro Ala Pro Val Val Glu Gln Ser Gly Lys Arg Lys Ser Lys 
                405                 410                 415     


Thr Lys Thr Ile Val Glu Pro Pro Arg Lys Arg Gln Thr Lys Thr Lys 
            420                 425                 430         


Asn Ile Val Glu Pro Pro Arg Lys Arg Gln Thr Lys Thr Lys Asn Ile 
        435                 440                 445             


Val Glu Pro Leu Arg Lys Arg Lys Ala Lys Thr Lys Asn Val Ser Val 
    450                 455                 460                 


Thr Pro Gly His Lys Lys Arg Gly Pro Ser Lys Lys Lys Pro Gly Ala 
465                 470                 475                 480 


Ala Lys Val Glu Lys Arg Lys Thr Arg Thr Pro Lys Cys Lys Val Pro 
                485                 490                 495     


Gly Cys Phe Leu Gln Asp Leu Glu Lys Ser Lys Lys Tyr Ser Gly Lys 
            500                 505                 510         


Asn Leu Lys Arg Asn Lys Asp Glu Leu Val Gln Arg Ile Tyr Asp Leu 
        515                 520                 525             


Phe Asn Arg Ser Val Cys Asp Lys Lys Leu Pro Glu Lys Leu Arg Ile 
    530                 535                 540                 


Gly Trp Asn Asn Lys Met Val Lys Thr Ala Gly Leu Cys Ser Thr Gly 
545                 550                 555                 560 


Glu Met Trp Tyr Pro Lys Trp Arg Arg Phe Ala Lys Ile Gln Ile Gly 
                565                 570                 575     


Leu Lys Val Cys Asp Ser Ala Asp Arg Ile Arg Asp Thr Leu Ile His 
            580                 585                 590         


Glu Met Cys His Ala Ala Ser Trp Leu Ile Asp Gly Ile His Asp Ser 
        595                 600                 605             


His Gly Asp Ala Trp Lys Tyr Tyr Ala Arg Lys Ser Asn Arg Ile His 
    610                 615                 620                 


Pro Glu Leu Pro Arg Val Thr Arg Cys His Asn Tyr Lys Ile Asn Tyr 
625                 630                 635                 640 


Lys Val His Tyr Glu Cys Thr Gly Cys Lys Thr Arg Ile Gly Cys Tyr 
                645                 650                 655     


Thr Lys Ser Leu Asp Thr Ser Arg Phe Ile Cys Ala Lys Cys Lys Gly 
            660                 665                 670         


Ser Leu Val Met Val Pro Leu Thr Gln Lys Asp Gly Thr Arg Ile Val 
        675                 680                 685             


Pro His Val 
    690     


<210>  141
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACR__Homo_sapiens__NP_001088

<400>  141

Met Val Glu Met Leu Pro Thr Ala Ile Leu Leu Val Leu Ala Val Ser 
1               5                   10                  15      


Val Val Ala Lys Asp Asn Ala Thr Cys Asp Gly Pro Cys Gly Leu Arg 
            20                  25                  30          


Phe Arg Gln Asn Pro Gln Gly Gly Val Arg Ile Val Gly Gly Lys Ala 
        35                  40                  45              


Ala Gln His Gly Ala Trp Pro Trp Met Val Ser Leu Gln Ile Phe Thr 
    50                  55                  60                  


Tyr Asn Ser His Arg Tyr His Thr Cys Gly Gly Ser Leu Leu Asn Ser 
65                  70                  75                  80  


Arg Trp Val Leu Thr Ala Ala His Cys Phe Val Gly Lys Asn Asn Val 
                85                  90                  95      


His Asp Trp Arg Leu Val Phe Gly Ala Lys Glu Ile Thr Tyr Gly Asn 
            100                 105                 110         


Asn Lys Pro Val Lys Ala Pro Leu Gln Glu Arg Tyr Val Glu Lys Ile 
        115                 120                 125             


Ile Ile His Glu Lys Tyr Asn Ser Ala Thr Glu Gly Asn Asp Ile Ala 
    130                 135                 140                 


Leu Val Glu Ile Thr Pro Pro Ile Ser Cys Gly Arg Phe Ile Gly Pro 
145                 150                 155                 160 


Gly Cys Leu Pro His Phe Lys Ala Gly Leu Pro Arg Gly Ser Gln Ser 
                165                 170                 175     


Cys Trp Val Ala Gly Trp Gly Tyr Ile Glu Glu Lys Ala Pro Arg Pro 
            180                 185                 190         


Ser Ser Ile Leu Met Glu Ala Arg Val Asp Leu Ile Asp Leu Asp Leu 
        195                 200                 205             


Cys Asn Ser Thr Gln Trp Tyr Asn Gly Arg Val Gln Pro Thr Asn Val 
    210                 215                 220                 


Cys Ala Gly Tyr Pro Val Gly Lys Ile Asp Thr Cys Gln Gly Asp Ser 
225                 230                 235                 240 


Gly Gly Pro Leu Met Cys Lys Asp Ser Lys Glu Ser Ala Tyr Val Val 
                245                 250                 255     


Val Gly Ile Thr Ser Trp Gly Val Gly Cys Ala Arg Ala Lys Arg Pro 
            260                 265                 270         


Gly Ile Tyr Thr Ala Thr Trp Pro Tyr Leu Asn Trp Ile Ala Ser Lys 
        275                 280                 285             


Ile Gly Ser Asn Ala Leu Arg Met Ile Gln Ser Ala Thr Pro Pro Pro 
    290                 295                 300                 


Pro Thr Thr Arg Pro Pro Pro Ile Arg Pro Pro Phe Ser His Pro Ile 
305                 310                 315                 320 


Ser Ala His Leu Pro Trp Tyr Phe Gln Pro Pro Pro Arg Pro Leu Pro 
                325                 330                 335     


Pro Arg Pro Pro Ala Ala Gln Pro Arg Pro Pro Pro Ser Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Pro Pro Ala Ser Pro Leu Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Pro Pro Thr Pro Ser Ser Thr Thr Lys Leu Pro Gln Gly Leu Ser Phe 
    370                 375                 380                 


Ala Lys Arg Leu Gln Gln Leu Ile Glu Val Leu Lys Gly Lys Thr Tyr 
385                 390                 395                 400 


Ser Asp Gly Lys Asn His Tyr Asp Met Glu Thr Thr Glu Leu Pro Glu 
                405                 410                 415     


Leu Thr Ser Thr Ser 
            420     


<210>  142
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACRV1__Homo_sapiens__NP_001603

<400>  142

Met Asn Arg Phe Leu Leu Leu Met Ser Leu Tyr Leu Leu Gly Ser Ala 
1               5                   10                  15      


Arg Gly Thr Ser Ser Gln Pro Asn Glu Leu Ser Gly Ser Ile Asp His 
            20                  25                  30          


Gln Thr Ser Val Gln Gln Leu Pro Gly Glu Phe Phe Ser Leu Glu Asn 
        35                  40                  45              


Pro Ser Asp Ala Glu Ala Leu Tyr Glu Thr Ser Ser Gly Leu Asn Thr 
    50                  55                  60                  


Leu Ser Glu His Gly Ser Ser Glu His Gly Ser Ser Lys His Thr Val 
65                  70                  75                  80  


Ala Glu His Thr Ser Gly Glu His Ala Glu Ser Glu His Ala Ser Gly 
                85                  90                  95      


Glu Pro Ala Ala Thr Glu His Ala Glu Gly Glu His Thr Val Gly Glu 
            100                 105                 110         


Gln Pro Ser Gly Glu Gln Pro Ser Gly Glu His Leu Ser Gly Glu Gln 
        115                 120                 125             


Pro Leu Ser Glu Leu Glu Ser Gly Glu Gln Pro Ser Asp Glu Gln Pro 
    130                 135                 140                 


Ser Gly Glu His Gly Ser Gly Glu Gln Pro Ser Gly Glu Gln Ala Ser 
145                 150                 155                 160 


Gly Glu Gln Pro Ser Gly Glu His Ala Ser Gly Glu Gln Ala Ser Gly 
                165                 170                 175     


Ala Pro Ile Ser Ser Thr Ser Thr Gly Thr Ile Leu Asn Cys Tyr Thr 
            180                 185                 190         


Cys Ala Tyr Met Asn Asp Gln Gly Lys Cys Leu Arg Gly Glu Gly Thr 
        195                 200                 205             


Cys Ile Thr Gln Asn Ser Gln Gln Cys Met Leu Lys Lys Ile Phe Glu 
    210                 215                 220                 


Gly Gly Lys Leu Gln Phe Met Val Gln Gly Cys Glu Asn Met Cys Pro 
225                 230                 235                 240 


Ser Met Asn Leu Phe Ser His Gly Thr Arg Met Gln Ile Ile Cys Cys 
                245                 250                 255     


Arg Asn Gln Ser Phe Cys Asn Lys Ile 
            260                 265 


<210>  143
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSBG1__Homo_sapiens__NP_055977

<400>  143

Met Pro Arg Asn Ser Gly Ala Gly Tyr Gly Cys Pro His Gly Asp Pro 
1               5                   10                  15      


Ser Met Leu Asp Ser Arg Glu Thr Pro Gln Glu Ser Arg Gln Asp Met 
            20                  25                  30          


Ile Val Arg Thr Thr Gln Glu Lys Leu Lys Thr Ser Ser Leu Thr Asp 
        35                  40                  45              


Arg Gln Pro Leu Ser Lys Glu Ser Leu Asn His Ala Leu Glu Leu Ser 
    50                  55                  60                  


Val Pro Glu Lys Val Asn Asn Ala Gln Trp Asp Ala Pro Glu Glu Ala 
65                  70                  75                  80  


Leu Trp Thr Thr Arg Ala Asp Gly Arg Val Arg Leu Arg Ile Asp Pro 
                85                  90                  95      


Ser Cys Pro Gln Leu Pro Tyr Thr Val His Arg Met Phe Tyr Glu Ala 
            100                 105                 110         


Leu Asp Lys Tyr Gly Asp Leu Ile Ala Leu Gly Phe Lys Arg Gln Asp 
        115                 120                 125             


Lys Trp Glu His Ile Ser Tyr Ser Gln Tyr Tyr Leu Leu Ala Arg Arg 
    130                 135                 140                 


Ala Ala Lys Gly Phe Leu Lys Leu Gly Leu Lys Gln Ala His Ser Val 
145                 150                 155                 160 


Ala Ile Leu Gly Phe Asn Ser Pro Glu Trp Phe Phe Ser Ala Val Gly 
                165                 170                 175     


Thr Val Phe Ala Gly Gly Ile Val Thr Gly Ile Tyr Thr Thr Ser Ser 
            180                 185                 190         


Pro Glu Ala Cys Gln Tyr Ile Ala Tyr Asp Cys Cys Ala Asn Val Ile 
        195                 200                 205             


Met Val Asp Thr Gln Lys Gln Leu Glu Lys Ile Leu Lys Ile Trp Lys 
    210                 215                 220                 


Gln Leu Pro His Leu Lys Ala Val Val Ile Tyr Lys Glu Pro Pro Pro 
225                 230                 235                 240 


Asn Lys Met Ala Asn Val Tyr Thr Met Glu Glu Phe Met Glu Leu Gly 
                245                 250                 255     


Asn Glu Val Pro Glu Glu Ala Leu Asp Ala Ile Ile Asp Thr Gln Gln 
            260                 265                 270         


Pro Asn Gln Cys Cys Val Leu Val Tyr Thr Ser Gly Thr Thr Gly Asn 
        275                 280                 285             


Pro Lys Gly Val Met Leu Ser Gln Asp Asn Ile Thr Trp Thr Ala Arg 
    290                 295                 300                 


Tyr Gly Ser Gln Ala Gly Asp Ile Arg Pro Ala Glu Val Gln Gln Glu 
305                 310                 315                 320 


Val Val Val Ser Tyr Leu Pro Leu Ser His Ile Ala Ala Gln Ile Tyr 
                325                 330                 335     


Asp Leu Trp Thr Gly Ile Gln Trp Gly Ala Gln Val Cys Phe Ala Glu 
            340                 345                 350         


Pro Asp Ala Leu Lys Gly Ser Leu Val Asn Thr Leu Arg Glu Val Glu 
        355                 360                 365             


Pro Thr Ser His Met Gly Val Pro Arg Val Trp Glu Lys Ile Met Glu 
    370                 375                 380                 


Arg Ile Gln Glu Val Ala Ala Gln Ser Gly Phe Ile Arg Arg Lys Met 
385                 390                 395                 400 


Leu Leu Trp Ala Met Ser Val Thr Leu Glu Gln Asn Leu Thr Cys Pro 
                405                 410                 415     


Gly Ser Asp Leu Lys Pro Phe Thr Thr Arg Leu Ala Asp Tyr Leu Val 
            420                 425                 430         


Leu Ala Lys Val Arg Gln Ala Leu Gly Phe Ala Lys Cys Gln Lys Asn 
        435                 440                 445             


Phe Tyr Gly Ala Ala Pro Met Met Ala Glu Thr Gln His Phe Phe Leu 
    450                 455                 460                 


Gly Leu Asn Ile Arg Leu Tyr Ala Gly Tyr Gly Leu Ser Glu Thr Ser 
465                 470                 475                 480 


Gly Pro His Phe Met Ser Ser Pro Tyr Asn Tyr Arg Leu Tyr Ser Ser 
                485                 490                 495     


Gly Lys Leu Val Pro Gly Cys Arg Val Lys Leu Val Asn Gln Asp Ala 
            500                 505                 510         


Glu Gly Ile Gly Glu Ile Cys Leu Trp Gly Arg Thr Ile Phe Met Gly 
        515                 520                 525             


Tyr Leu Asn Met Glu Asp Lys Thr Cys Glu Ala Ile Asp Glu Glu Gly 
    530                 535                 540                 


Trp Leu His Thr Gly Asp Ala Gly Arg Leu Asp Ala Asp Gly Phe Leu 
545                 550                 555                 560 


Tyr Ile Thr Gly Arg Leu Lys Glu Leu Ile Ile Thr Ala Gly Gly Glu 
                565                 570                 575     


Asn Val Pro Pro Val Pro Ile Glu Glu Ala Val Lys Met Glu Leu Pro 
            580                 585                 590         


Ile Ile Ser Asn Ala Met Leu Ile Gly Asp Gln Arg Lys Phe Leu Ser 
        595                 600                 605             


Met Leu Leu Thr Leu Lys Cys Thr Leu Asp Pro Asp Thr Ser Asp Gln 
    610                 615                 620                 


Thr Asp Asn Leu Thr Glu Gln Ala Met Glu Phe Cys Gln Arg Val Gly 
625                 630                 635                 640 


Ser Arg Ala Thr Thr Val Ser Glu Ile Ile Glu Lys Lys Asp Glu Ala 
                645                 650                 655     


Val Tyr Gln Ala Ile Glu Glu Gly Ile Arg Arg Val Asn Met Asn Ala 
            660                 665                 670         


Ala Ala Arg Pro Tyr His Ile Gln Lys Trp Ala Ile Leu Glu Arg Asp 
        675                 680                 685             


Phe Ser Ile Ser Gly Gly Glu Leu Gly Pro Thr Met Lys Leu Lys Arg 
    690                 695                 700                 


Leu Thr Val Leu Glu Lys Tyr Lys Gly Ile Ile Asp Ser Phe Tyr Gln 
705                 710                 715                 720 


Glu Gln Lys Met 
                


<210>  144
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSBG2__Homo_sapiens__NP_001276107

<400>  144

Met Thr Gly Thr Pro Lys Thr Gln Glu Gly Ala Lys Asp Leu Glu Val 
1               5                   10                  15      


Asp Met Asn Lys Thr Glu Val Thr Pro Arg Leu Trp Thr Thr Cys Arg 
            20                  25                  30          


Asp Gly Glu Val Leu Leu Arg Leu Ser Lys His Gly Pro Gly His Glu 
        35                  40                  45              


Thr Pro Met Thr Ile Pro Glu Phe Phe Arg Glu Ser Val Asn Arg Phe 
    50                  55                  60                  


Gly Thr Tyr Pro Ala Leu Ala Ser Lys Asn Gly Lys Lys Trp Glu Ile 
65                  70                  75                  80  


Leu Asn Phe Asn Gln Tyr Tyr Glu Ala Cys Arg Lys Ala Ala Lys Ser 
                85                  90                  95      


Leu Ile Lys Leu Gly Leu Glu Arg Phe His Gly Val Gly Ile Leu Gly 
            100                 105                 110         


Phe Asn Ser Ala Glu Trp Phe Ile Thr Ala Val Gly Ala Ile Leu Ala 
        115                 120                 125             


Gly Gly Leu Cys Val Gly Ile Tyr Ala Thr Asn Ser Ala Glu Val Cys 
    130                 135                 140                 


Gln Tyr Val Ile Thr His Ala Lys Val Asn Ile Leu Leu Val Glu Asn 
145                 150                 155                 160 


Asp Gln Gln Leu Gln Lys Ile Leu Ser Ile Pro Gln Ser Ser Leu Glu 
                165                 170                 175     


Pro Leu Lys Ala Ile Ile Gln Tyr Arg Leu Pro Met Lys Lys Asn Asn 
            180                 185                 190         


Asn Leu Tyr Ser Trp Asp Asp Phe Met Glu Leu Gly Arg Ser Ile Pro 
        195                 200                 205             


Asp Thr Gln Leu Glu Gln Val Ile Glu Ser Gln Lys Ala Asn Gln Cys 
    210                 215                 220                 


Ala Val Leu Ile Tyr Thr Ser Gly Thr Thr Gly Ile Pro Lys Gly Val 
225                 230                 235                 240 


Met Leu Ser His Asp Asn Ile Thr Trp Ile Ala Gly Ala Val Thr Lys 
                245                 250                 255     


Asp Phe Lys Leu Thr Asp Lys His Glu Thr Val Val Ser Tyr Leu Pro 
            260                 265                 270         


Leu Ser His Ile Ala Ala Gln Met Met Asp Ile Trp Val Pro Ile Lys 
        275                 280                 285             


Ile Gly Ala Leu Thr Tyr Phe Ala Gln Ala Asp Ala Leu Lys Gly Thr 
    290                 295                 300                 


Leu Val Ser Thr Leu Lys Glu Val Lys Pro Thr Val Phe Ile Gly Val 
305                 310                 315                 320 


Pro Gln Ile Trp Glu Lys Ile His Glu Met Val Lys Lys Asn Ser Ala 
                325                 330                 335     


Lys Ser Met Gly Leu Lys Lys Lys Ala Phe Val Trp Ala Arg Asn Ile 
            340                 345                 350         


Gly Phe Lys Val Asn Ser Lys Lys Met Leu Gly Lys Tyr Asn Thr Pro 
        355                 360                 365             


Val Ser Tyr Arg Met Ala Lys Thr Leu Val Phe Ser Lys Val Lys Thr 
    370                 375                 380                 


Ser Leu Gly Leu Asp His Cys His Ser Phe Ile Ser Gly Thr Ala Pro 
385                 390                 395                 400 


Leu Asn Gln Glu Thr Ala Glu Phe Phe Leu Ser Leu Asp Ile Pro Ile 
                405                 410                 415     


Gly Glu Leu Tyr Gly Leu Ser Glu Ser Ser Gly Pro His Thr Ile Ser 
            420                 425                 430         


Asn Gln Asn Asn Tyr Arg Leu Leu Ser Cys Gly Lys Ile Leu Thr Gly 
        435                 440                 445             


Cys Lys Asn Met Leu Phe Gln Gln Asn Lys Asp Gly Ile Gly Glu Ile 
    450                 455                 460                 


Cys Leu Trp Gly Arg His Ile Phe Met Gly Tyr Leu Glu Ser Glu Thr 
465                 470                 475                 480 


Glu Thr Thr Glu Ala Ile Asp Asp Glu Gly Trp Leu His Ser Gly Asp 
                485                 490                 495     


Leu Gly Gln Leu Asp Gly Leu Gly Phe Leu Tyr Val Thr Gly His Ile 
            500                 505                 510         


Lys Glu Ile Leu Ile Thr Ala Gly Gly Glu Asn Val Pro Pro Ile Pro 
        515                 520                 525             


Val Glu Thr Leu Val Lys Lys Lys Ile Pro Ile Ile Ser Asn Ala Met 
    530                 535                 540                 


Leu Val Gly Asp Lys Leu Lys Phe Leu Ser Met Leu Leu Thr Leu Lys 
545                 550                 555                 560 


Cys Glu Met Asn Gln Met Ser Gly Glu Pro Leu Asp Lys Leu Asn Phe 
                565                 570                 575     


Glu Ala Ile Asn Phe Cys Arg Gly Leu Gly Ser Gln Ala Ser Thr Val 
            580                 585                 590         


Thr Glu Ile Val Lys Gln Gln Asp Pro Leu Val Tyr Lys Ala Ile Gln 
        595                 600                 605             


Gln Gly Ile Asn Ala Val Asn Gln Glu Ala Met Asn Asn Ala Gln Arg 
    610                 615                 620                 


Ile Glu Lys Trp Val Ile Leu Glu Lys Asp Phe Ser Ile Tyr Gly Gly 
625                 630                 635                 640 


Glu Leu Gly Pro Met Met Lys Leu Lys Arg His Phe Val Ala Gln Lys 
                645                 650                 655     


Tyr Lys Lys Gln Ile Asp His Met Tyr His 
            660                 665     


<210>  145
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSF3__Homo_sapiens__NP_777577

<400>  145

Met Leu Pro His Val Val Leu Thr Phe Arg Arg Leu Gly Cys Ala Leu 
1               5                   10                  15      


Ala Ser Cys Arg Leu Ala Pro Ala Arg His Arg Gly Ser Gly Leu Leu 
            20                  25                  30          


His Thr Ala Pro Val Ala Arg Ser Asp Arg Ser Ala Pro Val Phe Thr 
        35                  40                  45              


Arg Ala Leu Ala Phe Gly Asp Arg Ile Ala Leu Val Asp Gln His Gly 
    50                  55                  60                  


Arg His Thr Tyr Arg Glu Leu Tyr Ser Arg Ser Leu Arg Leu Ser Gln 
65                  70                  75                  80  


Glu Ile Cys Arg Leu Cys Gly Cys Val Gly Gly Asp Leu Arg Glu Glu 
                85                  90                  95      


Arg Val Ser Phe Leu Cys Ala Asn Asp Ala Ser Tyr Val Val Ala Gln 
            100                 105                 110         


Trp Ala Ser Trp Met Ser Gly Gly Val Ala Val Pro Leu Tyr Arg Lys 
        115                 120                 125             


His Pro Ala Ala Gln Leu Glu Tyr Val Ile Cys Asp Ser Gln Ser Ser 
    130                 135                 140                 


Val Val Leu Ala Ser Gln Glu Tyr Leu Glu Leu Leu Ser Pro Val Val 
145                 150                 155                 160 


Arg Lys Leu Gly Val Pro Leu Leu Pro Leu Thr Pro Ala Ile Tyr Thr 
                165                 170                 175     


Gly Ala Val Glu Glu Pro Ala Glu Val Pro Val Pro Glu Gln Gly Trp 
            180                 185                 190         


Arg Asn Lys Gly Ala Met Ile Ile Tyr Thr Ser Gly Thr Thr Gly Arg 
        195                 200                 205             


Pro Lys Gly Val Leu Ser Thr His Gln Asn Ile Arg Ala Val Val Thr 
    210                 215                 220                 


Gly Leu Val His Lys Trp Ala Trp Thr Lys Asp Asp Val Ile Leu His 
225                 230                 235                 240 


Val Leu Pro Leu His His Val His Gly Val Val Asn Ala Leu Leu Cys 
                245                 250                 255     


Pro Leu Trp Val Gly Ala Thr Cys Val Met Met Pro Glu Phe Ser Pro 
            260                 265                 270         


Gln Gln Val Trp Glu Lys Phe Leu Ser Ser Glu Thr Pro Arg Ile Asn 
        275                 280                 285             


Val Phe Met Ala Val Pro Thr Ile Tyr Thr Lys Leu Met Glu Tyr Tyr 
    290                 295                 300                 


Asp Arg His Phe Thr Gln Pro His Ala Gln Asp Phe Leu Arg Ala Val 
305                 310                 315                 320 


Cys Glu Glu Lys Ile Arg Leu Met Val Ser Gly Ser Ala Ala Leu Pro 
                325                 330                 335     


Leu Pro Val Leu Glu Lys Trp Lys Asn Ile Thr Gly His Thr Leu Leu 
            340                 345                 350         


Glu Arg Tyr Gly Met Thr Glu Ile Gly Met Ala Leu Ser Gly Pro Leu 
        355                 360                 365             


Thr Thr Ala Val Arg Leu Pro Gly Ser Val Gly Thr Pro Leu Pro Gly 
    370                 375                 380                 


Val Gln Val Arg Ile Val Ser Glu Asn Pro Gln Arg Glu Ala Cys Ser 
385                 390                 395                 400 


Tyr Thr Ile His Ala Glu Gly Asp Glu Arg Gly Thr Lys Val Thr Pro 
                405                 410                 415     


Gly Phe Glu Glu Lys Glu Gly Glu Leu Leu Val Arg Gly Pro Ser Val 
            420                 425                 430         


Phe Arg Glu Tyr Trp Asn Lys Pro Glu Glu Thr Lys Ser Ala Phe Thr 
        435                 440                 445             


Leu Asp Gly Trp Phe Lys Thr Gly Asp Thr Val Val Phe Lys Asp Gly 
    450                 455                 460                 


Gln Tyr Trp Ile Arg Gly Arg Thr Ser Val Asp Ile Ile Lys Thr Gly 
465                 470                 475                 480 


Gly Tyr Lys Val Ser Ala Leu Glu Val Glu Trp His Leu Leu Ala His 
                485                 490                 495     


Pro Ser Ile Thr Asp Val Ala Val Ile Gly Val Pro Asp Met Thr Trp 
            500                 505                 510         


Gly Gln Arg Val Thr Ala Val Val Thr Leu Arg Glu Gly His Ser Leu 
        515                 520                 525             


Ser His Arg Glu Leu Lys Glu Trp Ala Arg Asn Val Leu Ala Pro Tyr 
    530                 535                 540                 


Ala Val Pro Ser Glu Leu Val Leu Val Glu Glu Ile Pro Arg Asn Gln 
545                 550                 555                 560 


Met Gly Lys Ile Asp Lys Lys Ala Leu Ile Arg His Phe His Pro Ser 
                565                 570                 575     


<210>  146
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSL1__Homo_sapiens__NP_001273640

<400>  146

Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val 
1               5                   10                  15      


Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly 
            20                  25                  30          


Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro 
        35                  40                  45              


Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val 
    50                  55                  60                  


Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu 
65                  70                  75                  80  


Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe 
                85                  90                  95      


Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg 
            100                 105                 110         


Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Trp Val Ile 
        115                 120                 125             


Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro Leu Tyr 
    130                 135                 140                 


Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys Ala Glu 
145                 150                 155                 160 


Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu Leu Leu 
                165                 170                 175     


Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile Val Val 
            180                 185                 190         


Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg Cys Gly 
        195                 200                 205             


Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg Ala Asn 
    210                 215                 220                 


Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val Ile Cys 
225                 230                 235                 240 


Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val Thr His 
                245                 250                 255     


Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr Glu Asn 
            260                 265                 270         


Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu Pro Leu 
        275                 280                 285             


Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys His Gly 
    290                 295                 300                 


Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met Asp Asp 
305                 310                 315                 320 


Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg Leu Leu 
                325                 330                 335     


Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr Leu Lys 
            340                 345                 350         


Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu Leu Arg 
        355                 360                 365             


Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile Phe His 
    370                 375                 380                 


Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val Thr Gly 
385                 390                 395                 400 


Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala Ala Leu 
                405                 410                 415     


Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr Ala Gly 
            420                 425                 430         


Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val Gly Ala 
        435                 440                 445             


Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu Met Asn 
    450                 455                 460                 


Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly Pro Asn 
465                 470                 475                 480 


Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu Ala Leu 
                485                 490                 495     


Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp Leu Pro 
            500                 505                 510         


Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu 
        515                 520                 525             


Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile Tyr Met 
    530                 535                 540                 


Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser Leu Gln 
545                 550                 555                 560 


Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu Cys Ser 
                565                 570                 575     


Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu Cys Arg 
            580                 585                 590         


Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly 
        595                 600                 605             


Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile Thr Leu 
    610                 615                 620                 


His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro Thr Met 
625                 630                 635                 640 


Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln Ile Asp 
                645                 650                 655     


Asp Leu Tyr Ser Thr Ile Lys Val 
            660                 


<210>  147
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSL3__Homo_sapiens__NP_976251

<400>  147

Met Asn Asn His Val Ser Ser Lys Pro Ser Thr Met Lys Leu Lys His 
1               5                   10                  15      


Thr Ile Asn Pro Ile Leu Leu Tyr Phe Ile His Phe Leu Ile Ser Leu 
            20                  25                  30          


Tyr Thr Ile Leu Thr Tyr Ile Pro Phe Tyr Phe Phe Ser Glu Ser Arg 
        35                  40                  45              


Gln Glu Lys Ser Asn Arg Ile Lys Ala Lys Pro Val Asn Ser Lys Pro 
    50                  55                  60                  


Asp Ser Ala Tyr Arg Ser Val Asn Ser Leu Asp Gly Leu Ala Ser Val 
65                  70                  75                  80  


Leu Tyr Pro Gly Cys Asp Thr Leu Asp Lys Val Phe Thr Tyr Ala Lys 
                85                  90                  95      


Asn Lys Phe Lys Asn Lys Arg Leu Leu Gly Thr Arg Glu Val Leu Asn 
            100                 105                 110         


Glu Glu Asp Glu Val Gln Pro Asn Gly Lys Ile Phe Lys Lys Val Ile 
        115                 120                 125             


Leu Gly Gln Tyr Asn Trp Leu Ser Tyr Glu Asp Val Phe Val Arg Ala 
    130                 135                 140                 


Phe Asn Phe Gly Asn Gly Leu Gln Met Leu Gly Gln Lys Pro Lys Thr 
145                 150                 155                 160 


Asn Ile Ala Ile Phe Cys Glu Thr Arg Ala Glu Trp Met Ile Ala Ala 
                165                 170                 175     


Gln Ala Cys Phe Met Tyr Asn Phe Gln Leu Val Thr Leu Tyr Ala Thr 
            180                 185                 190         


Leu Gly Gly Pro Ala Ile Val His Ala Leu Asn Glu Thr Glu Val Thr 
        195                 200                 205             


Asn Ile Ile Thr Ser Lys Glu Leu Leu Gln Thr Lys Leu Lys Asp Ile 
    210                 215                 220                 


Val Ser Leu Val Pro Arg Leu Arg His Ile Ile Thr Val Asp Gly Lys 
225                 230                 235                 240 


Pro Pro Thr Trp Ser Glu Phe Pro Lys Gly Ile Ile Val His Thr Met 
                245                 250                 255     


Ala Ala Val Glu Ala Leu Gly Ala Lys Ala Ser Met Glu Asn Gln Pro 
            260                 265                 270         


His Ser Lys Pro Leu Pro Ser Asp Ile Ala Val Ile Met Tyr Thr Ser 
        275                 280                 285             


Gly Ser Thr Gly Leu Pro Lys Gly Val Met Ile Ser His Ser Asn Ile 
    290                 295                 300                 


Ile Ala Gly Ile Thr Gly Met Ala Glu Arg Ile Pro Glu Leu Gly Glu 
305                 310                 315                 320 


Glu Asp Val Tyr Ile Gly Tyr Leu Pro Leu Ala His Val Leu Glu Leu 
                325                 330                 335     


Ser Ala Glu Leu Val Cys Leu Ser His Gly Cys Arg Ile Gly Tyr Ser 
            340                 345                 350         


Ser Pro Gln Thr Leu Ala Asp Gln Ser Ser Lys Ile Lys Lys Gly Ser 
        355                 360                 365             


Lys Gly Asp Thr Ser Met Leu Lys Pro Thr Leu Met Ala Ala Val Pro 
    370                 375                 380                 


Glu Ile Met Asp Arg Ile Tyr Lys Asn Val Met Asn Lys Val Ser Glu 
385                 390                 395                 400 


Met Ser Ser Phe Gln Arg Asn Leu Phe Ile Leu Ala Tyr Asn Tyr Lys 
                405                 410                 415     


Met Glu Gln Ile Ser Lys Gly Arg Asn Thr Pro Leu Cys Asp Ser Phe 
            420                 425                 430         


Val Phe Arg Lys Val Arg Ser Leu Leu Gly Gly Asn Ile Arg Leu Leu 
        435                 440                 445             


Leu Cys Gly Gly Ala Pro Leu Ser Ala Thr Thr Gln Arg Phe Met Asn 
    450                 455                 460                 


Ile Cys Phe Cys Cys Pro Val Gly Gln Gly Tyr Gly Leu Thr Glu Ser 
465                 470                 475                 480 


Ala Gly Ala Gly Thr Ile Ser Glu Val Trp Asp Tyr Asn Thr Gly Arg 
                485                 490                 495     


Val Gly Ala Pro Leu Val Cys Cys Glu Ile Lys Leu Lys Asn Trp Glu 
            500                 505                 510         


Glu Gly Gly Tyr Phe Asn Thr Asp Lys Pro His Pro Arg Gly Glu Ile 
        515                 520                 525             


Leu Ile Gly Gly Gln Ser Val Thr Met Gly Tyr Tyr Lys Asn Glu Ala 
    530                 535                 540                 


Lys Thr Lys Ala Asp Phe Phe Glu Asp Glu Asn Gly Gln Arg Trp Leu 
545                 550                 555                 560 


Cys Thr Gly Asp Ile Gly Glu Phe Glu Pro Asp Gly Cys Leu Lys Ile 
                565                 570                 575     


Ile Asp Arg Lys Lys Asp Leu Val Lys Leu Gln Ala Gly Glu Tyr Val 
            580                 585                 590         


Ser Leu Gly Lys Val Glu Ala Ala Leu Lys Asn Leu Pro Leu Val Asp 
        595                 600                 605             


Asn Ile Cys Ala Tyr Ala Asn Ser Tyr His Ser Tyr Val Ile Gly Phe 
    610                 615                 620                 


Val Val Pro Asn Gln Lys Glu Leu Thr Glu Leu Ala Arg Lys Lys Gly 
625                 630                 635                 640 


Leu Lys Gly Thr Trp Glu Glu Leu Cys Asn Ser Cys Glu Met Glu Asn 
                645                 650                 655     


Glu Val Leu Lys Val Leu Ser Glu Ala Ala Ile Ser Ala Ser Leu Glu 
            660                 665                 670         


Lys Phe Glu Ile Pro Val Lys Ile Arg Leu Ser Pro Glu Pro Trp Thr 
        675                 680                 685             


Pro Glu Thr Gly Leu Val Thr Asp Ala Phe Lys Leu Lys Arg Lys Glu 
    690                 695                 700                 


Leu Lys Thr His Tyr Gln Ala Asp Ile Glu Arg Met Tyr Gly Arg Lys 
705                 710                 715                 720 


<210>  148
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSL5__Homo_sapiens__NP_057318

<400>  148

Met Asp Ala Leu Lys Pro Pro Cys Leu Trp Arg Asn His Glu Arg Gly 
1               5                   10                  15      


Lys Lys Asp Arg Asp Ser Cys Gly Arg Lys Asn Ser Glu Pro Gly Ser 
            20                  25                  30          


Pro His Ser Leu Glu Ala Leu Arg Asp Ala Ala Pro Ser Gln Gly Leu 
        35                  40                  45              


Asn Phe Leu Leu Leu Phe Thr Lys Met Leu Phe Ile Phe Asn Phe Leu 
    50                  55                  60                  


Phe Ser Pro Leu Pro Thr Pro Ala Leu Ile Cys Ile Leu Thr Phe Gly 
65                  70                  75                  80  


Ala Ala Ile Phe Leu Trp Leu Ile Thr Arg Pro Gln Pro Val Leu Pro 
                85                  90                  95      


Leu Leu Asp Leu Asn Asn Gln Ser Val Gly Ile Glu Gly Gly Ala Arg 
            100                 105                 110         


Lys Gly Val Ser Gln Lys Asn Asn Asp Leu Thr Ser Cys Cys Phe Ser 
        115                 120                 125             


Asp Ala Lys Thr Met Tyr Glu Val Phe Gln Arg Gly Leu Ala Val Ser 
    130                 135                 140                 


Asp Asn Gly Pro Cys Leu Gly Tyr Arg Lys Pro Asn Gln Pro Tyr Arg 
145                 150                 155                 160 


Trp Leu Ser Tyr Lys Gln Val Ser Asp Arg Ala Glu Tyr Leu Gly Ser 
                165                 170                 175     


Cys Leu Leu His Lys Gly Tyr Lys Ser Ser Pro Asp Gln Phe Val Gly 
            180                 185                 190         


Ile Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Ser Glu Leu Ala Cys 
        195                 200                 205             


Tyr Thr Tyr Ser Met Val Ala Val Pro Leu Tyr Asp Thr Leu Gly Pro 
    210                 215                 220                 


Glu Ala Ile Val His Ile Val Asn Lys Ala Asp Ile Ala Met Val Ile 
225                 230                 235                 240 


Cys Asp Thr Pro Gln Lys Ala Leu Val Leu Ile Gly Asn Val Glu Lys 
                245                 250                 255     


Gly Phe Thr Pro Ser Leu Lys Val Ile Ile Leu Met Asp Pro Phe Asp 
            260                 265                 270         


Asp Asp Leu Lys Gln Arg Gly Glu Lys Ser Gly Ile Glu Ile Leu Ser 
        275                 280                 285             


Leu Tyr Asp Ala Glu Asn Leu Gly Lys Glu His Phe Arg Lys Pro Val 
    290                 295                 300                 


Pro Pro Ser Pro Glu Asp Leu Ser Val Ile Cys Phe Thr Ser Gly Thr 
305                 310                 315                 320 


Thr Gly Asp Pro Lys Gly Ala Met Ile Thr His Gln Asn Ile Val Ser 
                325                 330                 335     


Asn Ala Ala Ala Phe Leu Lys Cys Val Glu His Ala Tyr Glu Pro Thr 
            340                 345                 350         


Pro Asp Asp Val Ala Ile Ser Tyr Leu Pro Leu Ala His Met Phe Glu 
        355                 360                 365             


Arg Ile Val Gln Ala Val Val Tyr Ser Cys Gly Ala Arg Val Gly Phe 
    370                 375                 380                 


Phe Gln Gly Asp Ile Arg Leu Leu Ala Asp Asp Met Lys Thr Leu Lys 
385                 390                 395                 400 


Pro Thr Leu Phe Pro Ala Val Pro Arg Leu Leu Asn Arg Ile Tyr Asp 
                405                 410                 415     


Lys Val Gln Asn Glu Ala Lys Thr Pro Leu Lys Lys Phe Leu Leu Lys 
            420                 425                 430         


Leu Ala Val Ser Ser Lys Phe Lys Glu Leu Gln Lys Gly Ile Ile Arg 
        435                 440                 445             


His Asp Ser Phe Trp Asp Lys Leu Ile Phe Ala Lys Ile Gln Asp Ser 
    450                 455                 460                 


Leu Gly Gly Arg Val Arg Val Ile Val Thr Gly Ala Ala Pro Met Ser 
465                 470                 475                 480 


Thr Ser Val Met Thr Phe Phe Arg Ala Ala Met Gly Cys Gln Val Tyr 
                485                 490                 495     


Glu Ala Tyr Gly Gln Thr Glu Cys Thr Gly Gly Cys Thr Phe Thr Leu 
            500                 505                 510         


Pro Gly Asp Trp Thr Ser Gly His Val Gly Val Pro Leu Ala Cys Asn 
        515                 520                 525             


Tyr Val Lys Leu Glu Asp Val Ala Asp Met Asn Tyr Phe Thr Val Asn 
    530                 535                 540                 


Asn Glu Gly Glu Val Cys Ile Lys Gly Thr Asn Val Phe Lys Gly Tyr 
545                 550                 555                 560 


Leu Lys Asp Pro Glu Lys Thr Gln Glu Ala Leu Asp Ser Asp Gly Trp 
                565                 570                 575     


Leu His Thr Gly Asp Ile Gly Arg Trp Leu Pro Asn Gly Thr Leu Lys 
            580                 585                 590         


Ile Ile Asp Arg Lys Lys Asn Ile Phe Lys Leu Ala Gln Gly Glu Tyr 
        595                 600                 605             


Ile Ala Pro Glu Lys Ile Glu Asn Ile Tyr Asn Arg Ser Gln Pro Val 
    610                 615                 620                 


Leu Gln Ile Phe Val His Gly Glu Ser Leu Arg Ser Ser Leu Val Gly 
625                 630                 635                 640 


Val Val Val Pro Asp Thr Asp Val Leu Pro Ser Phe Ala Ala Lys Leu 
                645                 650                 655     


Gly Val Lys Gly Ser Phe Glu Glu Leu Cys Gln Asn Gln Val Val Arg 
            660                 665                 670         


Glu Ala Ile Leu Glu Asp Leu Gln Lys Ile Gly Lys Glu Ser Gly Leu 
        675                 680                 685             


Lys Thr Phe Glu Gln Val Lys Ala Ile Phe Leu His Pro Glu Pro Phe 
    690                 695                 700                 


Ser Ile Glu Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Gly 
705                 710                 715                 720 


Glu Leu Ser Lys Tyr Phe Arg Thr Gln Ile Asp Ser Leu Tyr Glu His 
                725                 730                 735     


Ile Gln Asp 
            


<210>  149
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSL6__Homo_sapiens__NP_001009185

<400>  149

Met Leu Thr Phe Phe Leu Val Ser Gly Gly Ser Leu Trp Leu Phe Val 
1               5                   10                  15      


Glu Phe Val Leu Ser Leu Leu Glu Lys Met Gln Thr Gln Glu Ile Leu 
            20                  25                  30          


Arg Ile Leu Arg Leu Pro Glu Leu Gly Asp Leu Gly Gln Phe Phe Arg 
        35                  40                  45              


Ser Leu Ser Ala Thr Thr Leu Val Ser Met Gly Ala Leu Ala Ala Ile 
    50                  55                  60                  


Leu Ala Tyr Trp Phe Thr His Arg Pro Lys Ala Leu Gln Pro Pro Cys 
65                  70                  75                  80  


Asn Leu Leu Met Gln Ser Glu Glu Val Glu Asp Ser Gly Gly Ala Arg 
                85                  90                  95      


Arg Ser Val Ile Gly Ser Gly Pro Gln Leu Leu Thr His Tyr Tyr Asp 
            100                 105                 110         


Asp Ala Arg Thr Met Tyr Gln Val Phe Arg Arg Gly Leu Ser Ile Ser 
        115                 120                 125             


Gly Asn Gly Pro Cys Leu Gly Phe Arg Lys Pro Lys Gln Pro Tyr Gln 
    130                 135                 140                 


Trp Leu Ser Tyr Gln Glu Val Ala Asp Arg Ala Glu Phe Leu Gly Ser 
145                 150                 155                 160 


Gly Leu Leu Gln His Asn Cys Lys Ala Cys Thr Asp Gln Phe Ile Gly 
                165                 170                 175     


Val Phe Ala Gln Asn Arg Pro Glu Trp Ile Ile Val Glu Leu Ala Cys 
            180                 185                 190         


Tyr Thr Tyr Ser Met Val Val Val Pro Leu Tyr Asp Thr Leu Gly Pro 
        195                 200                 205             


Gly Ala Ile Arg Tyr Ile Ile Asn Thr Ala Asp Ile Ser Thr Val Ile 
    210                 215                 220                 


Val Asp Lys Pro Gln Lys Ala Val Leu Leu Leu Glu His Val Glu Arg 
225                 230                 235                 240 


Lys Glu Thr Pro Gly Leu Lys Leu Ile Ile Leu Met Asp Pro Phe Glu 
                245                 250                 255     


Glu Ala Leu Lys Glu Arg Gly Gln Lys Cys Gly Val Val Ile Lys Ser 
            260                 265                 270         


Met Gln Ala Val Glu Asp Cys Gly Gln Glu Asn His Gln Ala Pro Val 
        275                 280                 285             


Pro Pro Gln Pro Asp Asp Leu Ser Ile Val Cys Phe Thr Ser Gly Thr 
    290                 295                 300                 


Thr Gly Asn Pro Lys Gly Ala Met Leu Thr His Gly Asn Val Val Ala 
305                 310                 315                 320 


Asp Phe Ser Gly Phe Leu Lys Val Thr Glu Lys Val Ile Phe Pro Arg 
                325                 330                 335     


Gln Asp Asp Val Leu Ile Ser Phe Leu Pro Leu Ala His Met Phe Glu 
            340                 345                 350         


Arg Val Ile Gln Ser Val Val Tyr Cys His Gly Gly Arg Val Gly Phe 
        355                 360                 365             


Phe Gln Gly Asp Ile Arg Leu Leu Ser Asp Asp Met Lys Ala Leu Cys 
    370                 375                 380                 


Pro Thr Ile Phe Pro Val Val Pro Arg Leu Leu Asn Arg Met Tyr Asp 
385                 390                 395                 400 


Lys Ile Phe Ser Gln Ala Asn Thr Pro Leu Lys Arg Trp Leu Leu Glu 
                405                 410                 415     


Phe Ala Ala Lys Arg Lys Gln Ala Glu Val Arg Ser Gly Ile Ile Arg 
            420                 425                 430         


Asn Asp Ser Ile Trp Asp Glu Leu Phe Phe Asn Lys Ile Gln Ala Ser 
        435                 440                 445             


Leu Gly Gly Cys Val Arg Met Ile Val Thr Gly Ala Ala Pro Ala Ser 
    450                 455                 460                 


Pro Thr Val Leu Gly Phe Leu Arg Ala Ala Leu Gly Cys Gln Val Tyr 
465                 470                 475                 480 


Glu Gly Tyr Gly Gln Thr Glu Cys Thr Ala Gly Cys Thr Phe Thr Thr 
                485                 490                 495     


Pro Gly Asp Trp Thr Ser Gly His Val Gly Ala Pro Leu Pro Cys Asn 
            500                 505                 510         


His Ile Lys Leu Val Asp Val Glu Glu Leu Asn Tyr Trp Ala Cys Lys 
        515                 520                 525             


Gly Glu Gly Glu Ile Cys Val Arg Gly Pro Asn Val Phe Lys Gly Tyr 
    530                 535                 540                 


Leu Lys Asp Pro Asp Arg Thr Lys Glu Ala Leu Asp Ser Asp Gly Trp 
545                 550                 555                 560 


Leu His Thr Gly Asp Ile Gly Lys Trp Leu Pro Ala Gly Thr Leu Lys 
                565                 570                 575     


Ile Ile Asp Arg Lys Lys His Ile Phe Lys Leu Ala Gln Gly Glu Tyr 
            580                 585                 590         


Val Ala Pro Glu Lys Ile Glu Asn Ile Tyr Ile Arg Ser Gln Pro Val 
        595                 600                 605             


Ala Gln Ile Tyr Val His Gly Asp Ser Leu Lys Ala Phe Leu Val Gly 
    610                 615                 620                 


Ile Val Val Pro Asp Pro Glu Val Met Pro Ser Trp Ala Gln Lys Arg 
625                 630                 635                 640 


Gly Ile Glu Gly Thr Tyr Ala Asp Leu Cys Thr Asn Lys Asp Leu Lys 
                645                 650                 655     


Lys Ala Ile Leu Glu Asp Met Val Arg Leu Gly Lys Glu Ser Gly Leu 
            660                 665                 670         


His Ser Phe Glu Gln Val Lys Ala Ile His Ile His Ser Asp Met Phe 
        675                 680                 685             


Ser Val Gln Asn Gly Leu Leu Thr Pro Thr Leu Lys Ala Lys Arg Pro 
    690                 695                 700                 


Glu Leu Arg Glu Tyr Phe Lys Lys Gln Ile Glu Glu Leu Tyr Ser Ile 
705                 710                 715                 720 


Ser Met 
        


<210>  150
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSM1__Homo_sapiens__NP_001305819

<400>  150

Met Gln Trp Leu Met Arg Phe Arg Thr Leu Trp Gly Ile His Lys Ser 
1               5                   10                  15      


Phe His Asn Ile His Pro Ala Pro Ser Gln Leu Arg Cys Arg Ser Leu 
            20                  25                  30          


Ser Glu Phe Gly Ala Pro Arg Trp Asn Asp Tyr Glu Val Pro Glu Glu 
        35                  40                  45              


Phe Asn Phe Ala Ser Tyr Val Leu Asp Tyr Trp Ala Gln Lys Glu Lys 
    50                  55                  60                  


Glu Gly Lys Arg Gly Pro Asn Pro Ala Phe Trp Trp Val Asn Gly Gln 
65                  70                  75                  80  


Gly Asp Glu Val Lys Trp Ser Phe Arg Glu Met Gly Asp Leu Thr Arg 
                85                  90                  95      


Arg Val Ala Asn Val Phe Thr Gln Thr Cys Gly Leu Gln Gln Gly Asp 
            100                 105                 110         


His Leu Ala Leu Met Leu Pro Arg Val Pro Glu Trp Trp Leu Val Ala 
        115                 120                 125             


Val Gly Cys Met Arg Thr Gly Ile Ile Phe Ile Pro Ala Thr Ile Leu 
    130                 135                 140                 


Leu Lys Ala Lys Asp Ile Leu Tyr Arg Leu Gln Leu Ser Lys Ala Lys 
145                 150                 155                 160 


Gly Ile Val Thr Ile Asp Ala Leu Ala Ser Glu Val Asp Ser Ile Ala 
                165                 170                 175     


Ser Gln Cys Pro Ser Leu Lys Thr Lys Leu Leu Val Ser Asp His Ser 
            180                 185                 190         


Arg Glu Gly Trp Leu Asp Phe Arg Ser Leu Val Lys Ser Ala Ser Pro 
        195                 200                 205             


Glu His Thr Cys Val Lys Ser Lys Thr Leu Asp Pro Met Val Ile Phe 
    210                 215                 220                 


Phe Thr Ser Gly Thr Thr Gly Phe Pro Lys Met Ala Lys His Ser His 
225                 230                 235                 240 


Gly Leu Ala Leu Gln Pro Ser Phe Pro Gly Ser Arg Lys Leu Arg Ser 
                245                 250                 255     


Leu Lys Thr Ser Asp Val Ser Trp Cys Leu Ser Asp Ser Gly Trp Ile 
            260                 265                 270         


Val Ala Thr Ile Trp Thr Leu Val Glu Pro Trp Thr Ala Gly Cys Thr 
        275                 280                 285             


Val Phe Ile His His Leu Pro Gln Phe Asp Thr Lys Val Ile Ile Gln 
    290                 295                 300                 


Thr Leu Leu Lys Tyr Pro Ile Asn His Phe Trp Gly Val Ser Ser Ile 
305                 310                 315                 320 


Tyr Arg Met Ile Leu Gln Gln Asp Phe Thr Ser Ile Arg Phe Pro Ala 
                325                 330                 335     


Leu Glu His Cys Tyr Thr Gly Gly Glu Val Val Leu Pro Lys Asp Gln 
            340                 345                 350         


Glu Glu Trp Lys Arg Arg Thr Gly Leu Leu Leu Tyr Glu Asn Tyr Gly 
        355                 360                 365             


Gln Ser Glu Thr Gly Leu Ile Cys Ala Thr Tyr Trp Gly Met Lys Ile 
    370                 375                 380                 


Lys Pro Gly Phe Met Gly Lys Ala Thr Pro Pro Tyr Asp Val Gln Val 
385                 390                 395                 400 


Ile Asp Asp Lys Gly Ser Ile Leu Pro Pro Asn Thr Glu Gly Asn Ile 
                405                 410                 415     


Gly Ile Arg Ile Lys Pro Val Arg Pro Val Ser Leu Phe Met Cys Tyr 
            420                 425                 430         


Glu Gly Asp Pro Glu Lys Thr Ala Lys Val Glu Cys Gly Asp Phe Tyr 
        435                 440                 445             


Asn Thr Gly Asp Arg Gly Lys Met Asp Glu Glu Gly Tyr Ile Cys Phe 
    450                 455                 460                 


Leu Gly Arg Ser Asp Asp Ile Ile Asn Ala Ser Gly Tyr Arg Ile Gly 
465                 470                 475                 480 


Pro Ala Glu Val Glu Ser Ala Leu Val Glu His Pro Ala Val Ala Glu 
                485                 490                 495     


Ser Ala Val Val Gly Ser Pro Asp Pro Ile Arg Gly Glu Val Val Lys 
            500                 505                 510         


Ala Phe Ile Val Leu Thr Pro Gln Phe Leu Ser His Asp Lys Asp Gln 
        515                 520                 525             


Leu Thr Lys Glu Leu Gln Gln His Val Lys Ser Val Thr Ala Pro Tyr 
    530                 535                 540                 


Lys Tyr Pro Arg Lys Val Glu Phe Val Ser Glu Leu Pro Lys Thr Ile 
545                 550                 555                 560 


Thr Gly Lys Ile Glu Arg Lys Glu Leu Arg Lys Lys Glu Thr Gly Gln 
                565                 570                 575     


Met 
    


<210>  151
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSM2B__Homo_sapiens__NP_001098539

<400>  151

Met His Trp Leu Arg Lys Val Gln Gly Leu Cys Thr Leu Trp Gly Thr 
1               5                   10                  15      


Gln Met Ser Ser Arg Thr Leu Tyr Ile Asn Ser Arg Gln Leu Val Ser 
            20                  25                  30          


Leu Gln Trp Gly His Gln Glu Val Pro Ala Lys Phe Asn Phe Ala Ser 
        35                  40                  45              


Asp Val Leu Asp His Trp Ala Asp Met Glu Lys Ala Gly Lys Arg Leu 
    50                  55                  60                  


Pro Ser Pro Ala Leu Trp Trp Val Asn Gly Lys Gly Lys Glu Leu Met 
65                  70                  75                  80  


Trp Asn Phe Arg Glu Leu Ser Glu Asn Ser Gln Gln Ala Ala Asn Ile 
                85                  90                  95      


Leu Ser Gly Ala Cys Gly Leu Gln Arg Gly Asp Arg Val Ala Val Met 
            100                 105                 110         


Leu Pro Arg Val Pro Glu Trp Trp Leu Val Ile Leu Gly Cys Ile Arg 
        115                 120                 125             


Ala Gly Leu Ile Phe Met Pro Gly Thr Ile Gln Met Lys Ser Thr Asp 
    130                 135                 140                 


Ile Leu Tyr Arg Leu Gln Met Ser Lys Ala Lys Ala Ile Val Ala Gly 
145                 150                 155                 160 


Asp Glu Val Ile Gln Glu Val Asp Thr Val Ala Ser Glu Cys Pro Ser 
                165                 170                 175     


Leu Arg Ile Lys Leu Leu Val Ser Glu Lys Ser Cys Asp Gly Trp Leu 
            180                 185                 190         


Asn Phe Lys Lys Leu Leu Asn Glu Ala Ser Thr Thr His His Cys Val 
        195                 200                 205             


Glu Thr Gly Ser Gln Glu Ala Ser Ala Ile Tyr Phe Thr Ser Gly Thr 
    210                 215                 220                 


Ser Gly Leu Pro Lys Met Ala Glu His Ser Tyr Ser Ser Leu Gly Leu 
225                 230                 235                 240 


Lys Ala Lys Met Asp Ala Gly Trp Thr Gly Leu Gln Ala Ser Asp Ile 
                245                 250                 255     


Met Trp Thr Ile Ser Asp Thr Gly Trp Ile Leu Asn Ile Leu Gly Ser 
            260                 265                 270         


Leu Leu Glu Ser Trp Thr Leu Gly Ala Cys Thr Phe Val His Leu Leu 
        275                 280                 285             


Pro Lys Phe Asp Pro Leu Val Ile Leu Lys Thr Leu Ser Ser Tyr Pro 
    290                 295                 300                 


Ile Lys Ser Met Met Gly Ala Pro Ile Val Tyr Arg Met Leu Leu Gln 
305                 310                 315                 320 


Gln Asp Leu Ser Ser Tyr Lys Phe Pro His Leu Gln Asn Cys Leu Ala 
                325                 330                 335     


Gly Gly Glu Ser Leu Leu Pro Glu Thr Leu Glu Asn Trp Arg Ala Gln 
            340                 345                 350         


Thr Gly Leu Asp Ile Arg Glu Phe Tyr Gly Gln Thr Glu Thr Gly Leu 
        355                 360                 365             


Thr Cys Met Val Ser Lys Thr Met Lys Ile Lys Pro Gly Tyr Met Gly 
    370                 375                 380                 


Thr Ala Ala Ser Cys Tyr Asp Val Gln Val Ile Asp Asp Lys Gly Asn 
385                 390                 395                 400 


Val Leu Pro Pro Gly Thr Glu Gly Asp Ile Gly Ile Arg Val Lys Pro 
                405                 410                 415     


Ile Arg Pro Ile Gly Ile Phe Ser Gly Tyr Val Glu Asn Pro Asp Lys 
            420                 425                 430         


Thr Ala Ala Asn Ile Arg Gly Asp Phe Trp Leu Leu Gly Asp Arg Gly 
        435                 440                 445             


Ile Lys Asp Glu Asp Gly Tyr Phe Gln Phe Met Gly Arg Ala Asp Asp 
    450                 455                 460                 


Ile Ile Asn Ser Ser Gly Tyr Arg Ile Gly Pro Ser Glu Val Glu Asn 
465                 470                 475                 480 


Ala Leu Met Lys His Pro Ala Val Val Glu Thr Ala Val Ile Ser Ser 
                485                 490                 495     


Pro Asp Pro Val Arg Gly Glu Val Val Lys Ala Phe Val Ile Leu Ala 
            500                 505                 510         


Ser Gln Phe Leu Ser His Asp Pro Glu Gln Leu Thr Lys Glu Leu Gln 
        515                 520                 525             


Gln His Val Lys Ser Val Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Ile 
    530                 535                 540                 


Glu Phe Val Leu Asn Leu Pro Lys Thr Val Thr Gly Lys Ile Gln Arg 
545                 550                 555                 560 


Thr Lys Leu Arg Asp Lys Glu Trp Lys Met Ser Gly Lys Ala Arg Ala 
                565                 570                 575     


Gln 
    


<210>  152
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSM3__Homo_sapiens__NP_005613

<400>  152

Met Leu Ala Arg Val Thr Arg Lys Met Leu Arg His Ala Lys Cys Phe 
1               5                   10                  15      


Gln Arg Leu Ala Ile Phe Gly Ser Val Arg Ala Leu His Lys Asp Asn 
            20                  25                  30          


Arg Thr Ala Thr Pro Gln Asn Phe Ser Asn Tyr Glu Ser Met Lys Gln 
        35                  40                  45              


Asp Phe Lys Leu Gly Ile Pro Glu Tyr Phe Asn Phe Ala Lys Asp Val 
    50                  55                  60                  


Leu Asp Gln Trp Thr Asp Lys Glu Lys Ala Gly Lys Lys Pro Ser Asn 
65                  70                  75                  80  


Pro Ala Phe Trp Trp Ile Asn Arg Asn Gly Glu Glu Met Arg Trp Ser 
                85                  90                  95      


Phe Glu Glu Leu Gly Ser Leu Ser Arg Lys Phe Ala Asn Ile Leu Ser 
            100                 105                 110         


Glu Ala Cys Ser Leu Gln Arg Gly Asp Arg Val Ile Leu Ile Leu Pro 
        115                 120                 125             


Arg Val Pro Glu Trp Trp Leu Ala Asn Val Ala Cys Leu Arg Thr Gly 
    130                 135                 140                 


Thr Val Leu Ile Pro Gly Thr Thr Gln Leu Thr Gln Lys Asp Ile Leu 
145                 150                 155                 160 


Tyr Arg Leu Gln Ser Ser Lys Ala Asn Cys Ile Ile Thr Asn Asp Val 
                165                 170                 175     


Leu Ala Pro Ala Val Asp Ala Val Ala Ser Lys Cys Glu Asn Leu His 
            180                 185                 190         


Ser Lys Leu Ile Val Ser Glu Asn Ser Arg Glu Gly Trp Gly Asn Leu 
        195                 200                 205             


Lys Glu Leu Met Lys His Ala Ser Asp Ser His Thr Cys Val Lys Thr 
    210                 215                 220                 


Lys His Asn Glu Ile Met Ala Ile Phe Phe Thr Ser Gly Thr Ser Gly 
225                 230                 235                 240 


Tyr Pro Lys Met Thr Ala His Thr His Ser Ser Phe Gly Leu Gly Leu 
                245                 250                 255     


Ser Val Asn Gly Arg Phe Trp Leu Asp Leu Thr Pro Ser Asp Val Met 
            260                 265                 270         


Trp Asn Thr Ser Asp Thr Gly Trp Ala Lys Ser Ala Trp Ser Ser Val 
        275                 280                 285             


Phe Ser Pro Trp Ile Gln Gly Ala Cys Val Phe Thr His His Leu Pro 
    290                 295                 300                 


Arg Phe Glu Pro Thr Ser Ile Leu Gln Thr Leu Ser Lys Tyr Pro Ile 
305                 310                 315                 320 


Thr Val Phe Cys Ser Ala Pro Thr Val Tyr Arg Met Leu Val Gln Asn 
                325                 330                 335     


Asp Ile Thr Ser Tyr Lys Phe Lys Ser Leu Lys His Cys Val Ser Ala 
            340                 345                 350         


Gly Glu Pro Ile Thr Pro Asp Val Thr Glu Lys Trp Arg Asn Lys Thr 
        355                 360                 365             


Gly Leu Asp Ile Tyr Glu Gly Tyr Gly Gln Thr Glu Thr Val Leu Ile 
    370                 375                 380                 


Cys Gly Asn Phe Lys Gly Met Lys Ile Lys Pro Gly Ser Met Gly Lys 
385                 390                 395                 400 


Pro Ser Pro Ala Phe Asp Val Lys Ile Val Asp Val Asn Gly Asn Val 
                405                 410                 415     


Leu Pro Pro Gly Gln Glu Gly Asp Ile Gly Ile Gln Val Leu Pro Asn 
            420                 425                 430         


Arg Pro Phe Gly Leu Phe Thr His Tyr Val Asp Asn Pro Ser Lys Thr 
        435                 440                 445             


Ala Ser Thr Leu Arg Gly Asn Phe Tyr Ile Thr Gly Asp Arg Gly Tyr 
    450                 455                 460                 


Met Asp Lys Asp Gly Tyr Phe Trp Phe Val Ala Arg Ala Asp Asp Val 
465                 470                 475                 480 


Ile Leu Ser Ser Gly Tyr Arg Ile Gly Pro Phe Glu Val Glu Asn Ala 
                485                 490                 495     


Leu Asn Glu His Pro Ser Val Ala Glu Ser Ala Val Val Ser Ser Pro 
            500                 505                 510         


Asp Pro Ile Arg Gly Glu Val Val Lys Ala Phe Val Val Leu Asn Pro 
        515                 520                 525             


Asp Tyr Lys Ser His Asp Gln Glu Gln Leu Ile Lys Glu Ile Gln Glu 
    530                 535                 540                 


His Val Lys Lys Thr Thr Ala Pro Tyr Lys Tyr Pro Arg Lys Val Glu 
545                 550                 555                 560 


Phe Ile Gln Glu Leu Pro Lys Thr Ile Ser Gly Lys Thr Lys Arg Asn 
                565                 570                 575     


Glu Leu Arg Lys Lys Glu Trp Lys Thr Ile 
            580                 585     


<210>  153
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSS1__Homo_sapiens__NP_001239605

<400>  153

Met Arg Arg Arg Lys Glu Arg Gln Pro Trp Asp Arg Phe His Phe Leu 
1               5                   10                  15      


His Phe Ala Pro His Gly Arg Glu Leu Leu Glu Thr Thr Cys Arg Leu 
            20                  25                  30          


Ala Asn Thr Leu Lys Arg His Gly Val His Arg Gly Asp Arg Val Ala 
        35                  40                  45              


Ile Tyr Met Pro Val Ser Pro Leu Ala Val Ala Ala Met Leu Ala Cys 
    50                  55                  60                  


Ala Arg Ile Gly Ala Val His Thr Val Ile Phe Ala Gly Phe Ser Ala 
65                  70                  75                  80  


Glu Ser Leu Ala Gly Arg Ile Asn Asp Ala Lys Cys Lys Val Val Ile 
                85                  90                  95      


Thr Phe Asn Gln Gly Leu Arg Gly Gly Arg Val Val Glu Leu Lys Lys 
            100                 105                 110         


Ile Val Asp Glu Ala Val Lys His Cys Pro Thr Val Gln His Val Leu 
        115                 120                 125             


Val Ala His Arg Thr Asp Asn Lys Val His Met Gly Asp Leu Asp Val 
    130                 135                 140                 


Pro Leu Glu Gln Glu Met Ala Lys Glu Asp Pro Val Cys Ala Pro Glu 
145                 150                 155                 160 


Ser Met Gly Ser Glu Asp Met Leu Phe Met Leu Tyr Thr Ser Gly Ser 
                165                 170                 175     


Thr Gly Met Pro Lys Gly Ile Val His Thr Gln Ala Gly Tyr Leu Leu 
            180                 185                 190         


Tyr Ala Ala Leu Thr His Lys Leu Val Phe Asp His Gln Pro Gly Asp 
        195                 200                 205             


Ile Phe Gly Cys Val Ala Asp Ile Gly Trp Ile Thr Gly His Ser Tyr 
    210                 215                 220                 


Val Val Tyr Gly Pro Leu Cys Asn Gly Ala Thr Ser Val Leu Phe Glu 
225                 230                 235                 240 


Ser Thr Pro Val Tyr Pro Asn Ala Gly Arg Tyr Trp Glu Thr Val Glu 
                245                 250                 255     


Arg Leu Lys Ile Asn Gln Phe Tyr Gly Ala Pro Thr Ala Val Arg Leu 
            260                 265                 270         


Leu Leu Lys Tyr Gly Asp Ala Trp Val Lys Lys Tyr Asp Arg Ser Ser 
        275                 280                 285             


Leu Arg Thr Leu Gly Ser Val Gly Glu Pro Ile Asn Cys Glu Ala Trp 
    290                 295                 300                 


Glu Trp Leu His Arg Val Val Gly Asp Ser Arg Cys Thr Leu Val Asp 
305                 310                 315                 320 


Thr Trp Trp Gln Thr Glu Thr Gly Gly Ile Cys Ile Ala Pro Arg Pro 
                325                 330                 335     


Ser Glu Glu Gly Ala Glu Ile Leu Pro Ala Met Ala Met Arg Pro Phe 
            340                 345                 350         


Phe Gly Ile Val Pro Val Leu Met Asp Glu Lys Gly Ser Val Val Glu 
        355                 360                 365             


Gly Ser Asn Val Ser Gly Ala Leu Cys Ile Ser Gln Ala Trp Pro Gly 
    370                 375                 380                 


Met Ala Arg Thr Ile Tyr Gly Asp His Gln Arg Phe Val Asp Ala Tyr 
385                 390                 395                 400 


Phe Lys Ala Tyr Pro Gly Tyr Tyr Phe Thr Gly Asp Gly Ala Tyr Arg 
                405                 410                 415     


Thr Glu Gly Gly Tyr Tyr Gln Ile Thr Gly Arg Met Asp Asp Val Ile 
            420                 425                 430         


Asn Ile Ser Gly His Arg Leu Gly Thr Ala Glu Ile Glu Asp Ala Ile 
        435                 440                 445             


Ala Asp His Pro Ala Val Pro Glu Ser Ala Val Ile Gly Tyr Pro His 
    450                 455                 460                 


Asp Ile Lys Gly Glu Ala Ala Phe Ala Phe Ile Val Val Lys Asp Ser 
465                 470                 475                 480 


Ala Gly Asp Ser Asp Val Val Val Gln Glu Leu Lys Ser Met Val Ala 
                485                 490                 495     


Thr Lys Ile Ala Lys Tyr Ala Val Pro Asp Glu Ile Leu Val Val Lys 
            500                 505                 510         


Arg Leu Pro Lys Thr Arg Ser Gly Lys Val Met Arg Arg Leu Leu Arg 
        515                 520                 525             


Lys Ile Ile Thr Ser Glu Ala Gln Glu Leu Gly Asp Thr Thr Thr Leu 
    530                 535                 540                 


Glu Asp Pro Ser Ile Ile Ala Glu Ile Leu Ser Val Tyr Gln Lys Cys 
545                 550                 555                 560 


Lys Asp Lys Gln Ala Ala Ala Lys 
                565             


<210>  154
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSS2__Homo_sapiens__NP_001070020

<400>  154

Met Gly Leu Pro Glu Glu Arg Val Arg Ser Gly Ser Gly Ser Arg Gly 
1               5                   10                  15      


Gln Glu Glu Ala Gly Ala Gly Gly Arg Ala Arg Ser Trp Ser Pro Pro 
            20                  25                  30          


Pro Glu Val Ser Arg Ser Ala His Val Pro Ser Leu Gln Arg Tyr Arg 
        35                  40                  45              


Glu Leu His Arg Arg Ser Val Glu Glu Pro Arg Glu Phe Trp Gly Asp 
    50                  55                  60                  


Ile Ala Lys Glu Phe Tyr Trp Lys Thr Pro Cys Pro Gly Pro Phe Leu 
65                  70                  75                  80  


Arg Tyr Asn Phe Asp Val Thr Lys Gly Lys Ile Phe Ile Glu Trp Met 
                85                  90                  95      


Lys Gly Ala Thr Thr Asn Ile Cys Tyr Asn Val Leu Asp Arg Asn Val 
            100                 105                 110         


His Glu Lys Lys Leu Gly Asp Lys Val Ala Phe Tyr Trp Glu Gly Asn 
        115                 120                 125             


Glu Pro Gly Glu Thr Thr Gln Ile Thr Tyr His Gln Leu Leu Val Gln 
    130                 135                 140                 


Val Cys Gln Phe Ser Asn Val Leu Arg Lys Gln Gly Ile Gln Lys Gly 
145                 150                 155                 160 


Asp Arg Val Ala Ile Tyr Met Pro Met Ile Pro Glu Leu Val Val Ala 
                165                 170                 175     


Met Leu Ala Cys Ala Arg Ile Gly Ala Leu His Ser Ile Val Phe Ala 
            180                 185                 190         


Gly Phe Ser Ser Glu Ser Leu Cys Glu Arg Ile Leu Asp Ser Ser Cys 
        195                 200                 205             


Ser Leu Leu Ile Thr Thr Asp Ala Phe Tyr Arg Gly Glu Lys Leu Val 
    210                 215                 220                 


Asn Leu Lys Glu Leu Ala Asp Glu Ala Leu Gln Lys Cys Gln Glu Lys 
225                 230                 235                 240 


Gly Phe Pro Val Arg Cys Cys Ile Val Val Lys His Leu Gly Arg Ala 
                245                 250                 255     


Glu Leu Gly Met Gly Asp Ser Thr Ser Gln Ser Pro Pro Ile Lys Arg 
            260                 265                 270         


Ser Cys Pro Asp Val Gln Gly Lys Leu Lys Glu Lys Ser Lys Arg Val 
        275                 280                 285             


Gln Pro Gln Ile Ser Trp Asn Gln Gly Ile Asp Leu Trp Trp His Glu 
    290                 295                 300                 


Leu Met Gln Glu Ala Gly Asp Glu Cys Glu Pro Glu Trp Cys Asp Ala 
305                 310                 315                 320 


Glu Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro 
                325                 330                 335     


Lys Gly Val Val His Thr Val Gly Gly Tyr Met Leu Tyr Val Ala Thr 
            340                 345                 350         


Thr Phe Lys Tyr Val Phe Asp Phe His Ala Glu Asp Val Phe Trp Cys 
        355                 360                 365             


Thr Ala Asp Ile Gly Trp Ile Thr Gly His Ser Tyr Val Thr Tyr Gly 
    370                 375                 380                 


Pro Leu Ala Asn Gly Ala Thr Ser Val Leu Phe Glu Gly Ile Pro Thr 
385                 390                 395                 400 


Tyr Pro Asp Val Asn Arg Leu Trp Ser Ile Val Asp Lys Tyr Lys Val 
                405                 410                 415     


Thr Lys Phe Tyr Thr Ala Pro Thr Ala Ile Arg Leu Leu Met Lys Phe 
            420                 425                 430         


Gly Asp Glu Pro Val Thr Lys His Ser Arg Ala Ser Leu Gln Val Leu 
        435                 440                 445             


Gly Thr Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Leu Trp Tyr His 
    450                 455                 460                 


Arg Val Val Gly Ala Gln Arg Cys Pro Ile Val Asp Thr Phe Trp Gln 
465                 470                 475                 480 


Thr Glu Thr Gly Gly His Met Leu Thr Pro Leu Pro Gly Ala Thr Pro 
                485                 490                 495     


Met Lys Pro Gly Ser Ala Thr Phe Pro Phe Phe Gly Val Ala Pro Ala 
            500                 505                 510         


Ile Leu Asn Glu Ser Gly Glu Glu Leu Glu Gly Glu Ala Glu Gly Tyr 
        515                 520                 525             


Leu Val Phe Lys Gln Pro Trp Pro Gly Ile Met Arg Thr Val Tyr Gly 
    530                 535                 540                 


Asn His Glu Arg Phe Glu Thr Thr Tyr Phe Lys Lys Phe Pro Gly Tyr 
545                 550                 555                 560 


Tyr Val Thr Gly Asp Gly Cys Gln Arg Asp Gln Asp Gly Tyr Tyr Trp 
                565                 570                 575     


Ile Thr Gly Arg Ile Asp Asp Met Leu Asn Val Ser Gly His Leu Leu 
            580                 585                 590         


Ser Thr Ala Glu Val Glu Ser Ala Leu Val Glu His Glu Ala Val Ala 
        595                 600                 605             


Glu Ala Ala Val Val Gly His Pro His Pro Val Lys Gly Glu Cys Leu 
    610                 615                 620                 


Tyr Cys Phe Val Thr Leu Cys Asp Gly His Thr Phe Ser Pro Lys Leu 
625                 630                 635                 640 


Thr Glu Glu Leu Lys Lys Gln Ile Arg Glu Lys Ile Gly Pro Ile Ala 
                645                 650                 655     


Thr Pro Asp Tyr Ile Gln Asn Ala Pro Gly Leu Pro Lys Thr Arg Ser 
            660                 665                 670         


Gly Lys Ile Met Arg Arg Val Leu Arg Lys Ile Ala Gln Asn Asp His 
        675                 680                 685             


Asp Leu Gly Asp Met Ser Thr Val Ala Asp Pro Ser Val Ile Ser His 
    690                 695                 700                 


Leu Phe Ser His Arg Cys Leu Thr Ile Gln 
705                 710                 


<210>  155
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACSS3__Homo_sapiens__NP_078836

<400>  155

Met Lys Pro Ser Trp Leu Gln Cys Arg Lys Val Thr Ser Ala Gly Gly 
1               5                   10                  15      


Leu Gly Gly Pro Leu Pro Gly Ser Ser Pro Ala Arg Gly Ala Gly Ala 
            20                  25                  30          


Ala Leu Arg Ala Leu Val Val Pro Gly Pro Arg Gly Gly Leu Gly Gly 
        35                  40                  45              


Arg Gly Cys Arg Ala Leu Ser Ser Gly Ser Gly Ser Glu Tyr Lys Thr 
    50                  55                  60                  


His Phe Ala Ala Ser Val Thr Asp Pro Glu Arg Phe Trp Gly Lys Ala 
65                  70                  75                  80  


Ala Glu Gln Ile Ser Trp Tyr Lys Pro Trp Thr Lys Thr Leu Glu Asn 
                85                  90                  95      


Lys His Ser Pro Ser Thr Arg Trp Phe Val Glu Gly Met Leu Asn Ile 
            100                 105                 110         


Cys Tyr Asn Ala Val Asp Arg His Ile Glu Asn Gly Lys Gly Asp Lys 
        115                 120                 125             


Ile Ala Ile Ile Tyr Asp Ser Pro Val Thr Asn Thr Lys Ala Thr Phe 
    130                 135                 140                 


Thr Tyr Lys Glu Val Leu Glu Gln Val Ser Lys Leu Ala Gly Val Leu 
145                 150                 155                 160 


Val Lys His Gly Ile Lys Lys Gly Asp Thr Val Val Ile Tyr Met Pro 
                165                 170                 175     


Met Ile Pro Gln Ala Met Tyr Thr Met Leu Ala Cys Ala Arg Ile Gly 
            180                 185                 190         


Ala Ile His Ser Leu Ile Phe Gly Gly Phe Ala Ser Lys Glu Leu Ser 
        195                 200                 205             


Ser Arg Ile Asp His Val Lys Pro Lys Val Val Val Thr Ala Ser Phe 
    210                 215                 220                 


Gly Ile Glu Pro Gly Arg Arg Val Glu Tyr Val Pro Leu Val Glu Glu 
225                 230                 235                 240 


Ala Leu Lys Ile Gly Gln His Lys Pro Asp Lys Ile Leu Ile Tyr Asn 
                245                 250                 255     


Arg Pro Asn Met Glu Ala Val Pro Leu Ala Pro Gly Arg Asp Leu Asp 
            260                 265                 270         


Trp Asp Glu Glu Met Ala Lys Ala Gln Ser His Asp Cys Val Pro Val 
        275                 280                 285             


Leu Ser Glu His Pro Leu Tyr Ile Leu Tyr Thr Ser Gly Thr Thr Gly 
    290                 295                 300                 


Leu Pro Lys Gly Val Ile Arg Pro Thr Gly Gly Tyr Ala Val Met Leu 
305                 310                 315                 320 


His Trp Ser Met Ser Ser Ile Tyr Gly Leu Gln Pro Gly Glu Val Trp 
                325                 330                 335     


Trp Ala Ala Ser Asp Leu Gly Trp Val Val Gly His Ser Tyr Ile Cys 
            340                 345                 350         


Tyr Gly Pro Leu Leu His Gly Asn Thr Thr Val Leu Tyr Glu Gly Lys 
        355                 360                 365             


Pro Val Gly Thr Pro Asp Ala Gly Ala Tyr Phe Arg Val Leu Ala Glu 
    370                 375                 380                 


His Gly Val Ala Ala Leu Phe Thr Ala Pro Thr Ala Ile Arg Ala Ile 
385                 390                 395                 400 


Arg Gln Gln Asp Pro Gly Ala Ala Leu Gly Lys Gln Tyr Ser Leu Thr 
                405                 410                 415     


Arg Phe Lys Thr Leu Phe Val Ala Gly Glu Arg Cys Asp Val Glu Thr 
            420                 425                 430         


Leu Glu Trp Ser Lys Asn Val Phe Arg Val Pro Val Leu Asp His Trp 
        435                 440                 445             


Trp Gln Thr Glu Thr Gly Ser Pro Ile Thr Ala Ser Cys Val Gly Leu 
    450                 455                 460                 


Gly Asn Ser Lys Thr Pro Pro Pro Gly Gln Ala Gly Lys Ser Val Pro 
465                 470                 475                 480 


Gly Tyr Asn Val Met Ile Leu Asp Asp Asn Met Gln Lys Leu Lys Ala 
                485                 490                 495     


Arg Cys Leu Gly Asn Ile Val Val Lys Leu Pro Leu Pro Pro Gly Ala 
            500                 505                 510         


Phe Ser Gly Leu Trp Lys Asn Gln Glu Ala Phe Lys His Leu Tyr Phe 
        515                 520                 525             


Glu Lys Phe Pro Gly Tyr Tyr Asp Thr Met Asp Ala Gly Tyr Met Asp 
    530                 535                 540                 


Glu Glu Gly Tyr Leu Tyr Val Met Ser Arg Val Asp Asp Val Ile Asn 
545                 550                 555                 560 


Val Ala Gly His Arg Ile Ser Ala Gly Ala Ile Glu Glu Ser Ile Leu 
                565                 570                 575     


Ser His Gly Thr Val Ala Asp Cys Ala Val Val Gly Lys Glu Asp Pro 
            580                 585                 590         


Leu Lys Gly His Val Pro Leu Ala Leu Cys Val Leu Arg Lys Asp Ile 
        595                 600                 605             


Asn Ala Thr Glu Glu Gln Val Leu Glu Glu Ile Val Lys His Val Arg 
    610                 615                 620                 


Gln Asn Ile Gly Pro Val Ala Ala Phe Arg Asn Ala Val Phe Val Lys 
625                 630                 635                 640 


Gln Leu Pro Lys Thr Arg Ser Gly Lys Ile Pro Arg Ser Ala Leu Ser 
                645                 650                 655     


Ala Ile Val Asn Gly Lys Pro Tyr Lys Ile Thr Ser Thr Ile Glu Asp 
            660                 665                 670         


Pro Ser Ile Phe Gly His Val Glu Glu Met Leu Lys Gln Ala 
        675                 680                 685     


<210>  156
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTA1__Homo_sapiens__NP_001091

<400>  156

Met Cys Asp Glu Asp Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Met Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Thr Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  157
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTA2__Homo_sapiens__XP_011538318

<400>  157

Met Cys Glu Glu Glu Asp Ser Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Ser Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  158
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTB__Homo_sapiens__NP_001092

<400>  158

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  159
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTBL2__Homo_sapiens__NP_001017992

<400>  159

Met Thr Asp Asn Glu Leu Ser Ala Leu Val Val Asp Asn Gly Ser Gly 
1               5                   10                  15      


Met Cys Lys Ala Gly Phe Gly Gly Asp Asp Ala Pro Arg Ala Val Phe 
            20                  25                  30          


Pro Ser Met Ile Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met 
        35                  40                  45              


Gly Gln Lys Asp Cys Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly 
    50                  55                  60                  


Val Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Val Val Thr Asn Trp 
65                  70                  75                  80  


Asp Asp Met Glu Lys Ile Trp Tyr His Thr Phe Tyr Asn Glu Leu Arg 
                85                  90                  95      


Val Ala Pro Asp Glu His Pro Ile Leu Leu Thr Glu Ala Pro Leu Asn 
            100                 105                 110         


Pro Lys Ile Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Ala Phe 
        115                 120                 125             


Asn Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr 
    130                 135                 140                 


Ala Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val 
145                 150                 155                 160 


Thr His Ile Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile 
                165                 170                 175     


Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys 
            180                 185                 190         


Ile Leu Thr Glu Arg Gly Tyr Asn Phe Thr Thr Thr Ala Glu Arg Glu 
        195                 200                 205             


Ile Val Arg Asp Val Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe 
    210                 215                 220                 


Glu Gln Glu Met Val Arg Ala Ala Ala Ser Ser Ser Pro Glu Arg Ser 
225                 230                 235                 240 


Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe 
                245                 250                 255     


Arg Cys Pro Glu Ala Ile Phe Gln Pro Ser Phe Leu Gly Ile Glu Ser 
            260                 265                 270         


Ser Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val 
        275                 280                 285             


Asp Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Ile Thr 
305                 310                 315                 320 


Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg 
                325                 330                 335     


Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr 
            340                 345                 350         


Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly Pro 
        355                 360                 365             


Pro Ile Val His Arg Lys Cys Phe 
    370                 375     


<210>  160
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTC1__Homo_sapiens__NP_005150

<400>  160

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  161
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTG1__Homo_sapiens__NP_001605

<400>  161

Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  162
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTG2__Homo_sapiens__NP_001186822

<400>  162

Met Cys Glu Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser Gly 
1               5                   10                  15      


Leu Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe 
            20                  25                  30          


Pro Ser Ile Val Gly Arg Pro Arg His Gln Ile Trp His His Ser Phe 
        35                  40                  45              


Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr 
    50                  55                  60                  


Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile 
65                  70                  75                  80  


Met Phe Glu Thr Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala 
                85                  90                  95      


Val Leu Ser Leu Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp 
            100                 105                 110         


Ser Gly Asp Gly Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala 
        115                 120                 125             


Leu Pro His Ala Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr 
    130                 135                 140                 


Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr 
145                 150                 155                 160 


Thr Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr 
                165                 170                 175     


Val Ala Leu Asp Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser 
            180                 185                 190         


Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile 
        195                 200                 205             


Gly Asn Glu Arg Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe 
    210                 215                 220                 


Ile Gly Met Glu Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile 
225                 230                 235                 240 


Met Lys Cys Asp Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val 
                245                 250                 255     


Leu Ser Gly Gly Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln 
            260                 265                 270         


Lys Glu Ile Thr Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile 
        275                 280                 285             


Ala Pro Pro Glu Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu 
    290                 295                 300                 


Ala Ser Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys Pro Glu Tyr 
305                 310                 315                 320 


Asp Glu Ala Gly Pro Ser Ile Val His Arg Lys Cys Phe 
                325                 330             


<210>  163
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTL6A__Homo_sapiens__NP_004292

<400>  163

Met Ser Gly Gly Val Tyr Gly Gly Asp Glu Val Gly Ala Leu Val Phe 
1               5                   10                  15      


Asp Ile Gly Ser Tyr Thr Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys 
            20                  25                  30          


Pro Lys Val Asp Phe Pro Thr Ala Ile Gly Met Val Val Glu Arg Asp 
        35                  40                  45              


Asp Gly Ser Thr Leu Met Glu Ile Asp Gly Asp Lys Gly Lys Gln Gly 
    50                  55                  60                  


Gly Pro Thr Tyr Tyr Ile Asp Thr Asn Ala Leu Arg Val Pro Arg Glu 
65                  70                  75                  80  


Asn Met Glu Ala Ile Ser Pro Leu Lys Asn Gly Met Val Glu Asp Trp 
                85                  90                  95      


Asp Ser Phe Gln Ala Ile Leu Asp His Thr Tyr Lys Met His Val Lys 
            100                 105                 110         


Ser Glu Ala Ser Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn 
        115                 120                 125             


Thr Arg Ala Lys Arg Glu Lys Leu Thr Glu Leu Met Phe Glu His Tyr 
    130                 135                 140                 


Asn Ile Pro Ala Phe Phe Leu Cys Lys Thr Ala Val Leu Thr Ala Phe 
145                 150                 155                 160 


Ala Asn Gly Arg Ser Thr Gly Leu Ile Leu Asp Ser Gly Ala Thr His 
                165                 170                 175     


Thr Thr Ala Ile Pro Val His Asp Gly Tyr Val Leu Gln Gln Gly Ile 
            180                 185                 190         


Val Lys Ser Pro Leu Ala Gly Asp Phe Ile Thr Met Gln Cys Arg Glu 
        195                 200                 205             


Leu Phe Gln Glu Met Asn Ile Glu Leu Val Pro Pro Tyr Met Ile Ala 
    210                 215                 220                 


Ser Lys Glu Ala Val Arg Glu Gly Ser Pro Ala Asn Trp Lys Arg Lys 
225                 230                 235                 240 


Glu Lys Leu Pro Gln Val Thr Arg Ser Trp His Asn Tyr Met Cys Asn 
                245                 250                 255     


Cys Val Ile Gln Asp Phe Gln Ala Ser Val Leu Gln Val Ser Asp Ser 
            260                 265                 270         


Thr Tyr Asp Glu Gln Val Ala Ala Gln Met Pro Thr Val His Tyr Glu 
        275                 280                 285             


Phe Pro Asn Gly Tyr Asn Cys Asp Phe Gly Ala Glu Arg Leu Lys Ile 
    290                 295                 300                 


Pro Glu Gly Leu Phe Asp Pro Ser Asn Val Lys Gly Leu Ser Gly Asn 
305                 310                 315                 320 


Thr Met Leu Gly Val Ser His Val Val Thr Thr Ser Val Gly Met Cys 
                325                 330                 335     


Asp Ile Asp Ile Arg Pro Gly Leu Tyr Gly Ser Val Ile Val Ala Gly 
            340                 345                 350         


Gly Asn Thr Leu Ile Gln Ser Phe Thr Asp Arg Leu Asn Arg Glu Leu 
        355                 360                 365             


Ser Gln Lys Thr Pro Pro Ser Met Arg Leu Lys Leu Ile Ala Asn Asn 
    370                 375                 380                 


Thr Thr Val Glu Arg Arg Phe Ser Ser Trp Ile Gly Gly Ser Ile Leu 
385                 390                 395                 400 


Ala Ser Leu Gly Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr 
                405                 410                 415     


Glu Glu Gly Gly Lys Gln Cys Val Glu Arg Lys Cys Pro 
            420                 425                 


<210>  164
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTL6B__Homo_sapiens__NP_057272

<400>  164

Met Ser Gly Gly Val Tyr Gly Gly Asp Glu Val Gly Ala Leu Val Phe 
1               5                   10                  15      


Asp Ile Gly Ser Phe Ser Val Arg Ala Gly Tyr Ala Gly Glu Asp Cys 
            20                  25                  30          


Pro Lys Ala Asp Phe Pro Thr Thr Val Gly Leu Leu Ala Ala Glu Glu 
        35                  40                  45              


Gly Gly Gly Leu Glu Leu Glu Gly Asp Lys Glu Lys Lys Gly Lys Ile 
    50                  55                  60                  


Phe His Ile Asp Thr Asn Ala Leu His Val Pro Arg Asp Gly Ala Glu 
65                  70                  75                  80  


Val Met Ser Pro Leu Lys Asn Gly Met Ile Glu Asp Trp Glu Cys Phe 
                85                  90                  95      


Arg Ala Ile Leu Asp His Thr Tyr Ser Lys His Val Lys Ser Glu Pro 
            100                 105                 110         


Asn Leu His Pro Val Leu Met Ser Glu Ala Pro Trp Asn Thr Arg Ala 
        115                 120                 125             


Lys Arg Glu Lys Leu Thr Glu Leu Met Phe Glu Gln Tyr Asn Ile Pro 
    130                 135                 140                 


Ala Phe Phe Leu Cys Lys Thr Ala Val Leu Thr Ala Phe Ala Asn Gly 
145                 150                 155                 160 


Arg Ser Thr Gly Leu Val Leu Asp Ser Gly Ala Thr His Thr Thr Ala 
                165                 170                 175     


Ile Pro Val His Asp Gly Tyr Val Leu Gln Gln Gly Ile Val Lys Ser 
            180                 185                 190         


Pro Leu Ala Gly Asp Phe Ile Ser Met Gln Cys Arg Glu Leu Phe Gln 
        195                 200                 205             


Glu Met Ala Ile Asp Ile Ile Pro Pro Tyr Met Ile Ala Ala Lys Glu 
    210                 215                 220                 


Pro Val Arg Glu Gly Ala Pro Pro Asn Trp Lys Lys Lys Glu Lys Leu 
225                 230                 235                 240 


Pro Gln Val Ser Lys Ser Trp His Asn Tyr Met Cys Asn Glu Val Ile 
                245                 250                 255     


Gln Asp Phe Gln Ala Ser Val Leu Gln Val Ser Asp Ser Pro Tyr Asp 
            260                 265                 270         


Glu Gln Val Ala Ala Gln Met Pro Thr Val His Tyr Glu Met Pro Asn 
        275                 280                 285             


Gly Tyr Asn Thr Asp Tyr Gly Ala Glu Arg Leu Arg Ile Pro Glu Gly 
    290                 295                 300                 


Leu Phe Asp Pro Ser Asn Val Lys Gly Leu Ser Gly Asn Thr Met Leu 
305                 310                 315                 320 


Gly Val Gly His Val Val Thr Thr Ser Ile Gly Met Cys Asp Ile Asp 
                325                 330                 335     


Ile Arg Pro Gly Leu Tyr Gly Ser Val Ile Val Thr Gly Gly Asn Thr 
            340                 345                 350         


Leu Leu Gln Gly Phe Thr Asp Arg Leu Asn Arg Glu Leu Ser Gln Lys 
        355                 360                 365             


Thr Pro Pro Ser Met Arg Leu Lys Leu Ile Ala Ser Asn Ser Thr Met 
    370                 375                 380                 


Glu Arg Lys Phe Ser Pro Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu 
385                 390                 395                 400 


Gly Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Glu Glu Gly 
                405                 410                 415     


Gly Lys Gln Cys Val Glu Arg Lys Cys Pro 
            420                 425     


<210>  165
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTL8__Homo_sapiens__XP_011540513

<400>  165

Met Ser Leu Leu Pro Pro Arg Glu Ser Pro Ala Ala Ser Ser Ser Thr 
1               5                   10                  15      


Ser Val Pro Pro Thr Ser Ala Ser Ala Met Ala Ala Arg Thr Val Ile 
            20                  25                  30          


Ile Asp His Gly Ser Gly Phe Leu Lys Ala Gly Thr Ala Gly Trp Asn 
        35                  40                  45              


Glu Pro Gln Met Val Phe Pro Asn Ile Val Asn Tyr Leu Pro Cys Lys 
    50                  55                  60                  


Glu Asn Pro Gly Pro Ser Tyr Ala Arg Arg Arg Val Ser Leu Gly Ile 
65                  70                  75                  80  


Asp Ile Cys His Pro Asp Thr Phe Ser Tyr Pro Ile Glu Arg Gly Arg 
                85                  90                  95      


Ile Leu Asn Trp Glu Gly Val Gln Tyr Leu Trp Ser Phe Val Leu Glu 
            100                 105                 110         


Asn His Arg Arg Glu Gln Glu Val Pro Pro Val Ile Ile Thr Glu Thr 
        115                 120                 125             


Pro Leu Arg Glu Pro Ala Asp Arg Lys Lys Met Leu Glu Ile Leu Phe 
    130                 135                 140                 


Glu Leu Leu His Val Pro Ser Val Leu Leu Ala Asp Gln Leu Gln Met 
145                 150                 155                 160 


Ser Leu Tyr Ala Ser Gly Leu Leu Thr Gly Val Val Val Asp Ser Gly 
                165                 170                 175     


Tyr Gly Leu Thr Arg Val Gln Pro Phe His Gln Gly Arg Pro Leu Pro 
            180                 185                 190         


Ala Ser Gly Lys Thr Leu Glu Phe Ala Gly Gln Asp Leu Ser Ala Tyr 
        195                 200                 205             


Leu Leu Lys Ser Leu Phe Lys Glu Asp Cys Asp Arg Arg Cys Leu Phe 
    210                 215                 220                 


Gln Leu Glu Thr Val Ala Val Thr Gln Met Asn Lys Cys Tyr Val Pro 
225                 230                 235                 240 


Gln Asn Leu Gly Glu Ala Leu Asp Phe Arg Glu Arg Gln Gln Ser Ala 
                245                 250                 255     


Leu Asp Glu Ser Asn Thr Tyr Gln Leu Pro Asp Gly Ser Arg Val Glu 
            260                 265                 270         


Leu Thr Pro Met Gln Arg Val Ala Pro Glu Met Phe Phe Ser Pro Gln 
        275                 280                 285             


Val Phe Glu Gln Pro Gly Pro Ser Ile Pro Arg Ala Ile Val Glu Ser 
    290                 295                 300                 


Val Glu Ser Cys Glu Ile Ser Leu Arg Pro Leu Leu Val Ser His Val 
305                 310                 315                 320 


Met Ala Cys Gly Gly Asn Thr Leu Tyr Pro Gly Phe Thr Lys Arg Leu 
                325                 330                 335     


Phe Arg Glu Leu Met Gly Asp His Val Ser Ser Thr Lys Ala Thr Val 
            340                 345                 350         


Trp Glu Gly Ser Asn Arg Asn Phe Ser Val Trp Leu Gly Ala Ser Val 
        355                 360                 365             


Val Ala His Leu Ser Thr Tyr Gln Ser Glu Trp Met Ser Arg Glu Glu 
    370                 375                 380                 


Tyr Gly Glu His Met Arg Met 
385                 390     


<210>  166
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTL9__Homo_sapiens__NP_848620

<400>  166

Met Asp Ala Ser Arg Pro Lys Ser Ser Glu Ser Gln Ser Ser Leu Glu 
1               5                   10                  15      


Ala Pro Arg Pro Gly Pro Asn Pro Ser Pro Asn Val Val Asn Lys Pro 
            20                  25                  30          


Leu Gln Arg Asp Ser Pro Gly Met Val Ala Asp Arg Leu Pro Pro Lys 
        35                  40                  45              


Thr Gly Ala Val Val Ile Asp Met Gly Thr Gly Thr Cys Lys Val Gly 
    50                  55                  60                  


Phe Ala Gly Gln Ala Ser Pro Thr Tyr Thr Val Ala Thr Ile Leu Gly 
65                  70                  75                  80  


Cys Gln Pro Lys Lys Pro Ala Thr Ser Gly Gln Ser Gly Leu Gln Thr 
                85                  90                  95      


Phe Ile Gly Glu Ala Ala Arg Val Leu Pro Glu Leu Thr Leu Val Gln 
            100                 105                 110         


Pro Leu Arg Ser Gly Ile Val Val Asp Trp Asp Ala Ala Glu Leu Ile 
        115                 120                 125             


Trp Arg His Leu Leu Glu His Asp Leu Arg Val Ala Thr His Asp His 
    130                 135                 140                 


Pro Leu Leu Phe Ser Asp Pro Pro Phe Ser Pro Ala Thr Asn Arg Glu 
145                 150                 155                 160 


Lys Leu Val Glu Val Ala Phe Glu Ser Leu Arg Ser Pro Ala Met Tyr 
                165                 170                 175     


Val Ala Ser Gln Ser Val Leu Ser Val Tyr Ala His Gly Arg Val Ser 
            180                 185                 190         


Gly Leu Val Val Asp Thr Gly His Gly Val Thr Tyr Thr Val Pro Val 
        195                 200                 205             


Phe Gln Gly Tyr Asn Leu Leu His Ala Thr Glu Arg Leu Asp Leu Ala 
    210                 215                 220                 


Gly Asn Asn Leu Thr Ala Phe Leu Ala Glu Met Leu Leu Gln Ala Gly 
225                 230                 235                 240 


Leu Pro Leu Gly Gln Gln Asp Leu Asp Leu Val Glu Asn Ile Lys His 
                245                 250                 255     


His Tyr Cys Tyr Val Ala Ser Asp Phe Gln Lys Glu Gln Ala Arg Pro 
            260                 265                 270         


Glu Gln Glu Tyr Lys Arg Thr Leu Lys Leu Pro Asp Gly Arg Thr Val 
        275                 280                 285             


Thr Leu Gly Lys Glu Leu Phe Gln Cys Pro Glu Leu Leu Phe Asn Pro 
    290                 295                 300                 


Pro Glu Val Pro Gly Leu Ser Pro Val Gly Leu Ser Thr Met Ala Lys 
305                 310                 315                 320 


Gln Ser Leu Arg Lys Leu Ser Leu Glu Met Arg Ala Asp Leu Ala Gln 
                325                 330                 335     


Asn Val Leu Leu Cys Gly Gly Ser Ser Leu Phe Thr Gly Phe Glu Gly 
            340                 345                 350         


Arg Phe Arg Ala Glu Leu Leu Arg Ala Leu Pro Ala Glu Thr His Val 
        355                 360                 365             


Val Val Ala Ala Gln Pro Thr Arg Asn Phe Ser Val Trp Ile Gly Gly 
    370                 375                 380                 


Ser Ile Leu Ala Ser Leu Arg Ala Phe Gln Ser Cys Trp Val Leu Arg 
385                 390                 395                 400 


Glu Gln Tyr Glu Glu Gln Gly Pro Tyr Ile Val Tyr Arg Lys Cys Tyr 
                405                 410                 415     


<210>  167
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTN1__Homo_sapiens__NP_001093

<400>  167

Met Asp His Tyr Asp Ser Gln Gln Thr Asn Asp Tyr Met Gln Pro Glu 
1               5                   10                  15      


Glu Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln 
            20                  25                  30          


Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala 
        35                  40                  45              


Gly Thr Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asp Gly Leu Lys 
    50                  55                  60                  


Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Ala Lys Pro 
65                  70                  75                  80  


Glu Arg Gly Lys Met Arg Val His Lys Ile Ser Asn Val Asn Lys Ala 
                85                  90                  95      


Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala 
            100                 105                 110         


Glu Glu Ile Val Asp Gly Asn Val Lys Met Thr Leu Gly Met Ile Trp 
        115                 120                 125             


Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr 
    130                 135                 140                 


Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro 
145                 150                 155                 160 


Tyr Lys Asn Val Asn Ile Gln Asn Phe His Ile Ser Trp Lys Asp Gly 
                165                 170                 175     


Leu Gly Phe Cys Ala Leu Ile His Arg His Arg Pro Glu Leu Ile Asp 
            180                 185                 190         


Tyr Gly Lys Leu Arg Lys Asp Asp Pro Leu Thr Asn Leu Asn Thr Ala 
        195                 200                 205             


Phe Asp Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala 
    210                 215                 220                 


Glu Asp Ile Val Gly Thr Ala Arg Pro Asp Glu Lys Ala Ile Met Thr 
225                 230                 235                 240 


Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln Lys Ala Glu 
                245                 250                 255     


Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn 
            260                 265                 270         


Glu Gln Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp Leu Leu Glu 
        275                 280                 285             


Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asn Arg Val Pro Glu Asn 
    290                 295                 300                 


Thr Met His Ala Met Gln Gln Lys Leu Glu Asp Phe Arg Asp Tyr Arg 
305                 310                 315                 320 


Arg Leu His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln Leu Glu Ile 
                325                 330                 335     


Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn Arg Pro Ala 
            340                 345                 350         


Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn Asn Ala Trp 
        355                 360                 365             


Gly Cys Leu Glu Gln Val Glu Lys Gly Tyr Glu Glu Trp Leu Leu Asn 
    370                 375                 380                 


Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu Lys Phe Arg 
385                 390                 395                 400 


Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys Glu Ala Met 
                405                 410                 415     


Leu Arg Gln Lys Asp Tyr Glu Thr Ala Thr Leu Ser Glu Ile Lys Ala 
            420                 425                 430         


Leu Leu Lys Lys His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln 
        435                 440                 445             


Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu Asn Glu Leu 
    450                 455                 460                 


Asp Tyr Tyr Asp Ser Pro Ser Val Asn Ala Arg Cys Gln Lys Ile Cys 
465                 470                 475                 480 


Asp Gln Trp Asp Asn Leu Gly Ala Leu Thr Gln Lys Arg Arg Glu Ala 
                485                 490                 495     


Leu Glu Arg Thr Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Tyr Leu 
            500                 505                 510         


Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met Glu Gly Ala 
        515                 520                 525             


Met Glu Asp Leu Gln Asp Thr Phe Ile Val His Thr Ile Glu Glu Ile 
    530                 535                 540                 


Gln Gly Leu Thr Thr Ala His Glu Gln Phe Lys Ala Thr Leu Pro Asp 
545                 550                 555                 560 


Ala Asp Lys Glu Arg Leu Ala Ile Leu Gly Ile His Asn Glu Val Ser 
                565                 570                 575     


Lys Ile Val Gln Thr Tyr His Val Asn Met Ala Gly Thr Asn Pro Tyr 
            580                 585                 590         


Thr Thr Ile Thr Pro Gln Glu Ile Asn Gly Lys Trp Asp His Val Arg 
        595                 600                 605             


Gln Leu Val Pro Arg Arg Asp Gln Ala Leu Thr Glu Glu His Ala Arg 
    610                 615                 620                 


Gln Gln His Asn Glu Arg Leu Arg Lys Gln Phe Gly Ala Gln Ala Asn 
625                 630                 635                 640 


Val Ile Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile Gly Arg Ile 
                645                 650                 655     


Ser Ile Glu Met His Gly Thr Leu Glu Asp Gln Leu Ser His Leu Arg 
            660                 665                 670         


Gln Tyr Glu Lys Ser Ile Val Asn Tyr Lys Pro Lys Ile Asp Gln Leu 
        675                 680                 685             


Glu Gly Asp His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys 
    690                 695                 700                 


His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp Glu Gln Leu 
705                 710                 715                 720 


Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Ile Leu 
                725                 730                 735     


Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Asn Glu Phe Arg 
            740                 745                 750         


Ala Ser Phe Asn His Phe Asp Arg Asp His Ser Gly Thr Leu Gly Pro 
        755                 760                 765             


Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp Ile Gly Asn 
    770                 775                 780                 


Asp Pro Gln Gly Glu Ala Glu Phe Ala Arg Ile Met Ser Ile Val Asp 
785                 790                 795                 800 


Pro Asn Arg Leu Gly Val Val Thr Phe Gln Ala Phe Ile Asp Phe Met 
                805                 810                 815     


Ser Arg Glu Thr Ala Asp Thr Asp Thr Ala Asp Gln Val Met Ala Ser 
            820                 825                 830         


Phe Lys Ile Leu Ala Gly Asp Lys Asn Tyr Ile Thr Met Asp Glu Leu 
        835                 840                 845             


Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile Ala Arg Met 
    850                 855                 860                 


Ala Pro Tyr Thr Gly Pro Asp Ser Val Pro Gly Ala Leu Asp Tyr Met 
865                 870                 875                 880 


Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890         


<210>  168
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTN2__Homo_sapiens__NP_001094

<400>  168

Met Asn Gln Ile Glu Pro Gly Val Gln Tyr Asn Tyr Val Tyr Asp Glu 
1               5                   10                  15      


Asp Glu Tyr Met Ile Gln Glu Glu Glu Trp Asp Arg Asp Leu Leu Leu 
            20                  25                  30          


Asp Pro Ala Trp Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys 
        35                  40                  45              


Asn Ser His Leu Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Glu Glu 
    50                  55                  60                  


Asp Phe Arg Asn Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser 
65                  70                  75                  80  


Gly Glu Arg Leu Pro Lys Pro Asp Arg Gly Lys Met Arg Phe His Lys 
                85                  90                  95      


Ile Ala Asn Val Asn Lys Ala Leu Asp Tyr Ile Ala Ser Lys Gly Val 
            100                 105                 110         


Lys Leu Val Ser Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Val Lys 
        115                 120                 125             


Met Thr Leu Gly Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln 
    130                 135                 140                 


Asp Ile Ser Val Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp 
145                 150                 155                 160 


Cys Gln Arg Lys Thr Ala Pro Tyr Arg Asn Val Asn Ile Gln Asn Phe 
                165                 170                 175     


His Thr Ser Trp Lys Asp Gly Leu Gly Leu Cys Ala Leu Ile His Arg 
            180                 185                 190         


His Arg Pro Asp Leu Ile Asp Tyr Ser Lys Leu Asn Lys Asp Asp Pro 
        195                 200                 205             


Ile Gly Asn Ile Asn Leu Ala Met Glu Ile Ala Glu Lys His Leu Asp 
    210                 215                 220                 


Ile Pro Lys Met Leu Asp Ala Glu Asp Ile Val Asn Thr Pro Lys Pro 
225                 230                 235                 240 


Asp Glu Arg Ala Ile Met Thr Tyr Val Ser Cys Phe Tyr His Ala Phe 
                245                 250                 255     


Ala Gly Ala Glu Gln Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val 
            260                 265                 270         


Leu Ala Val Asn Gln Glu Asn Glu Arg Leu Met Glu Glu Tyr Glu Arg 
        275                 280                 285             


Leu Ala Ser Glu Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu 
    290                 295                 300                 


Glu Asn Arg Thr Pro Glu Lys Thr Met Gln Ala Met Gln Lys Lys Leu 
305                 310                 315                 320 


Glu Asp Phe Arg Asp Tyr Arg Arg Lys His Lys Pro Pro Lys Val Gln 
                325                 330                 335     


Glu Lys Cys Gln Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu 
            340                 345                 350         


Arg Ile Ser Asn Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val 
        355                 360                 365             


Ser Asp Ile Ala Gly Ala Trp Gln Arg Leu Glu Gln Ala Glu Lys Gly 
    370                 375                 380                 


Tyr Glu Glu Trp Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Glu 
385                 390                 395                 400 


His Leu Ala Glu Lys Phe Arg Gln Lys Ala Ser Thr His Glu Thr Trp 
                405                 410                 415     


Ala Tyr Gly Lys Glu Gln Ile Leu Leu Gln Lys Asp Tyr Glu Ser Ala 
            420                 425                 430         


Ser Leu Thr Glu Val Arg Ala Leu Leu Arg Lys His Glu Ala Phe Glu 
        435                 440                 445             


Ser Asp Leu Ala Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile 
    450                 455                 460                 


Ala Gln Glu Leu Asn Glu Leu Asp Tyr His Asp Ala Val Asn Val Asn 
465                 470                 475                 480 


Asp Arg Cys Gln Lys Ile Cys Asp Gln Trp Asp Arg Leu Gly Thr Leu 
                485                 490                 495     


Thr Gln Lys Arg Arg Glu Ala Leu Glu Arg Met Glu Lys Leu Leu Glu 
            500                 505                 510         


Thr Ile Asp Gln Leu His Leu Glu Phe Ala Lys Arg Ala Ala Pro Phe 
        515                 520                 525             


Asn Asn Trp Met Glu Gly Ala Met Glu Asp Leu Gln Asp Met Phe Ile 
    530                 535                 540                 


Val His Ser Ile Glu Glu Ile Gln Ser Leu Ile Thr Ala His Glu Gln 
545                 550                 555                 560 


Phe Lys Ala Thr Leu Pro Glu Ala Asp Gly Glu Arg Gln Ser Ile Met 
                565                 570                 575     


Ala Ile Gln Asn Glu Val Glu Lys Val Ile Gln Ser Tyr Asn Ile Arg 
            580                 585                 590         


Ile Ser Ser Ser Asn Pro Tyr Ser Thr Val Thr Met Asp Glu Leu Arg 
        595                 600                 605             


Thr Lys Trp Asp Lys Val Lys Gln Leu Val Pro Ile Arg Asp Gln Ser 
    610                 615                 620                 


Leu Gln Glu Glu Leu Ala Arg Gln His Ala Asn Glu Arg Leu Arg Arg 
625                 630                 635                 640 


Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly Pro Trp Ile Gln Asn Lys 
                645                 650                 655     


Met Glu Glu Ile Ala Arg Ser Ser Ile Gln Ile Thr Gly Ala Leu Glu 
            660                 665                 670         


Asp Gln Met Asn Gln Leu Lys Gln Tyr Glu His Asn Ile Ile Asn Tyr 
        675                 680                 685             


Lys Asn Asn Ile Asp Lys Leu Glu Gly Asp His Gln Leu Ile Gln Glu 
    690                 695                 700                 


Ala Leu Val Phe Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile 
705                 710                 715                 720 


Arg Val Gly Trp Glu Leu Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn 
                725                 730                 735     


Glu Val Glu Thr Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Thr Gln 
            740                 745                 750         


Glu Gln Met Asn Glu Phe Arg Ala Ser Phe Asn His Phe Asp Arg Arg 
        755                 760                 765             


Lys Asn Gly Leu Met Asp His Glu Asp Phe Arg Ala Cys Leu Ile Ser 
    770                 775                 780                 


Met Gly Tyr Asp Leu Gly Glu Ala Glu Phe Ala Arg Ile Met Thr Leu 
785                 790                 795                 800 


Val Asp Pro Asn Gly Gln Gly Thr Val Thr Phe Gln Ser Phe Ile Asp 
                805                 810                 815     


Phe Met Thr Arg Glu Thr Ala Asp Thr Asp Thr Ala Glu Gln Val Ile 
            820                 825                 830         


Ala Ser Phe Arg Ile Leu Ala Ser Asp Lys Pro Tyr Ile Leu Ala Glu 
        835                 840                 845             


Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Gln Tyr Cys Ile Lys 
    850                 855                 860                 


Arg Met Pro Ala Tyr Ser Gly Pro Gly Ser Val Pro Gly Ala Leu Asp 
865                 870                 875                 880 


Tyr Ala Ala Phe Ser Ser Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890                 


<210>  169
<211>  901
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTN3__Homo_sapiens__NP_001095

<400>  169

Met Met Met Val Met Gln Pro Glu Gly Leu Gly Ala Gly Glu Gly Arg 
1               5                   10                  15      


Phe Ala Gly Gly Gly Gly Gly Gly Glu Tyr Met Glu Gln Glu Glu Asp 
            20                  25                  30          


Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln Gln Arg 
        35                  40                  45              


Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala Gly Thr 
    50                  55                  60                  


Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asn Gly Leu Lys Leu Met 
65                  70                  75                  80  


Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Pro Arg Pro Asp Lys 
                85                  90                  95      


Gly Lys Met Arg Phe His Lys Ile Ala Asn Val Asn Lys Ala Leu Asp 
            100                 105                 110         


Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala Glu Glu 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Met Thr Leu Gly Met Ile Trp Thr Ile 
    130                 135                 140                 


Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr Ser Ala 
145                 150                 155                 160 


Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro Tyr Arg 
                165                 170                 175     


Asn Val Asn Val Gln Asn Phe His Thr Ser Trp Lys Asp Gly Leu Ala 
            180                 185                 190         


Leu Cys Ala Leu Ile His Arg His Arg Pro Asp Leu Ile Asp Tyr Ala 
        195                 200                 205             


Lys Leu Arg Lys Asp Asp Pro Ile Gly Asn Leu Asn Thr Ala Phe Glu 
    210                 215                 220                 


Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala Glu Asp 
225                 230                 235                 240 


Ile Val Asn Thr Pro Lys Pro Asp Glu Lys Ala Ile Met Thr Tyr Val 
                245                 250                 255     


Ser Cys Phe Tyr His Ala Phe Ala Gly Ala Glu Gln Ala Glu Thr Ala 
            260                 265                 270         


Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn Glu Lys 
        275                 280                 285             


Leu Met Glu Glu Tyr Glu Lys Leu Ala Ser Glu Leu Leu Glu Trp Ile 
    290                 295                 300                 


Arg Arg Thr Val Pro Trp Leu Glu Asn Arg Val Gly Glu Pro Ser Met 
305                 310                 315                 320 


Ser Ala Met Gln Arg Lys Leu Glu Asp Phe Arg Asp Tyr Arg Arg Leu 
                325                 330                 335     


His Lys Pro Pro Arg Ile Gln Glu Lys Cys Gln Leu Glu Ile Asn Phe 
            340                 345                 350         


Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser His Arg Pro Ala Phe Met 
        355                 360                 365             


Pro Ser Glu Gly Lys Leu Val Ser Asp Ile Ala Asn Ala Trp Arg Gly 
    370                 375                 380                 


Leu Glu Gln Val Glu Lys Gly Tyr Glu Asp Trp Leu Leu Ser Glu Ile 
385                 390                 395                 400 


Arg Arg Leu Gln Arg Leu Gln His Leu Ala Glu Lys Phe Arg Gln Lys 
                405                 410                 415     


Ala Ser Leu His Glu Ala Trp Thr Arg Gly Lys Glu Glu Met Leu Ser 
            420                 425                 430         


Gln Arg Asp Tyr Asp Ser Ala Leu Leu Gln Glu Val Arg Ala Leu Leu 
        435                 440                 445             


Arg Arg His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln Asp Arg 
    450                 455                 460                 


Val Glu His Ile Ala Ala Leu Ala Gln Glu Leu Asn Glu Leu Asp Tyr 
465                 470                 475                 480 


His Glu Ala Ala Ser Val Asn Ser Arg Cys Gln Ala Ile Cys Asp Gln 
                485                 490                 495     


Trp Asp Asn Leu Gly Thr Leu Thr Gln Lys Arg Arg Asp Ala Leu Glu 
            500                 505                 510         


Arg Met Glu Lys Leu Leu Glu Thr Ile Asp Arg Leu Gln Leu Glu Phe 
        515                 520                 525             


Ala Arg Arg Ala Ala Pro Phe Asn Asn Trp Leu Asp Gly Ala Val Glu 
    530                 535                 540                 


Asp Leu Gln Asp Val Trp Leu Val His Ser Val Glu Glu Thr Gln Ser 
545                 550                 555                 560 


Leu Leu Thr Ala His Asp Gln Phe Lys Ala Thr Leu Pro Glu Ala Asp 
                565                 570                 575     


Arg Glu Arg Gly Ala Ile Met Gly Ile Gln Gly Glu Ile Gln Lys Ile 
            580                 585                 590         


Cys Gln Thr Tyr Gly Leu Arg Pro Cys Ser Thr Asn Pro Tyr Ile Thr 
        595                 600                 605             


Leu Ser Pro Gln Asp Ile Asn Thr Lys Trp Asp Met Val Arg Lys Leu 
    610                 615                 620                 


Val Pro Ser Cys Asp Gln Thr Leu Gln Glu Glu Leu Ala Arg Gln Gln 
625                 630                 635                 640 


Val Asn Glu Arg Leu Arg Arg Gln Phe Ala Ala Gln Ala Asn Ala Ile 
                645                 650                 655     


Gly Pro Trp Ile Gln Ala Lys Val Glu Glu Val Gly Arg Leu Ala Ala 
            660                 665                 670         


Gly Leu Ala Gly Ser Leu Glu Glu Gln Met Ala Gly Leu Arg Gln Gln 
        675                 680                 685             


Glu Gln Asn Ile Ile Asn Tyr Lys Thr Asn Ile Asp Arg Leu Glu Gly 
    690                 695                 700                 


Asp His Gln Leu Leu Gln Glu Ser Leu Val Phe Asp Asn Lys His Thr 
705                 710                 715                 720 


Val Tyr Ser Met Glu His Ile Arg Val Gly Trp Glu Gln Leu Leu Thr 
                725                 730                 735     


Ser Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Val Leu Thr Arg 
            740                 745                 750         


Asp Ala Lys Gly Leu Ser Gln Glu Gln Leu Asn Glu Phe Arg Ala Ser 
        755                 760                 765             


Phe Asn His Phe Asp Arg Lys Gln Asn Gly Met Met Glu Pro Asp Asp 
    770                 775                 780                 


Phe Arg Ala Cys Leu Ile Ser Met Gly Tyr Asp Leu Gly Glu Val Glu 
785                 790                 795                 800 


Phe Ala Arg Ile Met Thr Met Val Asp Pro Asn Ala Ala Gly Val Val 
                805                 810                 815     


Thr Phe Gln Ala Phe Ile Asp Phe Met Thr Arg Glu Thr Ala Glu Thr 
            820                 825                 830         


Asp Thr Thr Glu Gln Val Val Ala Ser Phe Lys Ile Leu Ala Gly Asp 
        835                 840                 845             


Lys Asn Tyr Ile Thr Pro Glu Glu Leu Arg Arg Glu Leu Pro Ala Lys 
    850                 855                 860                 


Gln Ala Glu Tyr Cys Ile Arg Arg Met Val Pro Tyr Lys Gly Ser Gly 
865                 870                 875                 880 


Ala Pro Ala Gly Ala Leu Asp Tyr Val Ala Phe Ser Ser Ala Leu Tyr 
                885                 890                 895     


Gly Glu Ser Asp Leu 
            900     


<210>  170
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTN4__Homo_sapiens__NP_004915

<400>  170

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                485                 490                 495     


Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg 
            500                 505                 510         


Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln 
        515                 520                 525             


Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
    530                 535                 540                 


Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
545                 550                 555                 560 


Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                565                 570                 575     


Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
            580                 585                 590         


Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
        595                 600                 605             


Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
    610                 615                 620                 


Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
625                 630                 635                 640 


Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                645                 650                 655     


Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
            660                 665                 670         


Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
        675                 680                 685             


His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
    690                 695                 700                 


Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
705                 710                 715                 720 


Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp 
                725                 730                 735     


Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
            740                 745                 750         


Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
        755                 760                 765             


Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
    770                 775                 780                 


Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp 
785                 790                 795                 800 


Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser 
                805                 810                 815     


Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 
            820                 825                 830         


Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 
        835                 840                 845             


Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala 
    850                 855                 860                 


Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
865                 870                 875                 880 


Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu 
                885                 890                 895     


Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
            900                 905                 910     


<210>  171
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTR1A__Homo_sapiens__NP_005727

<400>  171

Met Glu Ser Tyr Asp Val Ile Ala Asn Gln Pro Val Val Ile Asp Asn 
1               5                   10                  15      


Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys 
            20                  25                  30          


Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Val Arg Val Met 
        35                  40                  45              


Ala Gly Ala Leu Glu Gly Asp Ile Phe Ile Gly Pro Lys Ala Glu Glu 
    50                  55                  60                  


His Arg Gly Leu Leu Ser Ile Arg Tyr Pro Met Glu His Gly Ile Val 
65                  70                  75                  80  


Lys Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys 
                85                  90                  95      


Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu 
            100                 105                 110         


Ala Pro Leu Asn Pro Arg Lys Asn Arg Glu Arg Ala Ala Glu Val Phe 
        115                 120                 125             


Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val 
    130                 135                 140                 


Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser 
145                 150                 155                 160 


Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met 
                165                 170                 175     


Pro His Ser Ile Met Arg Ile Asp Ile Ala Gly Arg Asp Val Ser Arg 
            180                 185                 190         


Phe Leu Arg Leu Tyr Leu Arg Lys Glu Gly Tyr Asp Phe His Ser Ser 
        195                 200                 205             


Ser Glu Phe Glu Ile Val Lys Ala Ile Lys Glu Arg Ala Cys Tyr Leu 
    210                 215                 220                 


Ser Ile Asn Pro Gln Lys Asp Glu Thr Leu Glu Thr Glu Lys Ala Gln 
225                 230                 235                 240 


Tyr Tyr Leu Pro Asp Gly Ser Thr Ile Glu Ile Gly Pro Ser Arg Phe 
                245                 250                 255     


Arg Ala Pro Glu Leu Leu Phe Arg Pro Asp Leu Ile Gly Glu Glu Ser 
            260                 265                 270         


Glu Gly Ile His Glu Val Leu Val Phe Ala Ile Gln Lys Ser Asp Met 
        275                 280                 285             


Asp Leu Arg Arg Thr Leu Phe Ser Asn Ile Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys 
305                 310                 315                 320 


Leu Ala Pro Lys Asp Val Lys Ile Arg Ile Ser Ala Pro Gln Glu Arg 
                325                 330                 335     


Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr 
            340                 345                 350         


Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ala 
        355                 360                 365             


Arg Ser Ile His Arg Lys Thr Phe 
    370                 375     


<210>  172
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTR1B__Homo_sapiens__NP_005726

<400>  172

Met Glu Ser Tyr Asp Ile Ile Ala Asn Gln Pro Val Val Ile Asp Asn 
1               5                   10                  15      


Gly Ser Gly Val Ile Lys Ala Gly Phe Ala Gly Asp Gln Ile Pro Lys 
            20                  25                  30          


Tyr Cys Phe Pro Asn Tyr Val Gly Arg Pro Lys His Met Arg Val Met 
        35                  40                  45              


Ala Gly Ala Leu Glu Gly Asp Leu Phe Ile Gly Pro Lys Ala Glu Glu 
    50                  55                  60                  


His Arg Gly Leu Leu Thr Ile Arg Tyr Pro Met Glu His Gly Val Val 
65                  70                  75                  80  


Arg Asp Trp Asn Asp Met Glu Arg Ile Trp Gln Tyr Val Tyr Ser Lys 
                85                  90                  95      


Asp Gln Leu Gln Thr Phe Ser Glu Glu His Pro Val Leu Leu Thr Glu 
            100                 105                 110         


Ala Pro Leu Asn Pro Ser Lys Asn Arg Glu Lys Ala Ala Glu Val Phe 
        115                 120                 125             


Phe Glu Thr Phe Asn Val Pro Ala Leu Phe Ile Ser Met Gln Ala Val 
    130                 135                 140                 


Leu Ser Leu Tyr Ala Thr Gly Arg Thr Thr Gly Val Val Leu Asp Ser 
145                 150                 155                 160 


Gly Asp Gly Val Thr His Ala Val Pro Ile Tyr Glu Gly Phe Ala Met 
                165                 170                 175     


Pro His Ser Ile Met Arg Val Asp Ile Ala Gly Arg Asp Val Ser Arg 
            180                 185                 190         


Tyr Leu Arg Leu Leu Leu Arg Lys Glu Gly Val Asp Phe His Thr Ser 
        195                 200                 205             


Ala Glu Phe Glu Val Val Arg Thr Ile Lys Glu Arg Ala Cys Tyr Leu 
    210                 215                 220                 


Ser Ile Asn Pro Gln Lys Asp Glu Ala Leu Glu Thr Glu Lys Val Gln 
225                 230                 235                 240 


Tyr Thr Leu Pro Asp Gly Ser Thr Leu Asp Val Gly Pro Ala Arg Phe 
                245                 250                 255     


Arg Ala Pro Glu Leu Leu Phe Gln Pro Asp Leu Val Gly Asp Glu Ser 
            260                 265                 270         


Glu Gly Leu His Glu Val Val Ala Phe Ala Ile His Lys Ser Asp Met 
        275                 280                 285             


Asp Leu Arg Arg Thr Leu Phe Ala Asn Ile Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Leu Phe Lys Gly Phe Gly Asp Arg Leu Leu Ser Glu Val Lys Lys 
305                 310                 315                 320 


Leu Ala Pro Lys Asp Ile Lys Ile Lys Ile Ser Ala Pro Gln Glu Arg 
                325                 330                 335     


Leu Tyr Ser Thr Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Asp Thr 
            340                 345                 350         


Phe Lys Lys Met Trp Val Ser Lys Lys Glu Tyr Glu Glu Asp Gly Ser 
        355                 360                 365             


Arg Ala Ile His Arg Lys Thr Phe 
    370                 375     


<210>  173
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTR2__Homo_sapiens__NP_001005386

<400>  173

Met Asp Ser Gln Gly Arg Lys Val Val Val Cys Asp Asn Gly Thr Gly 
1               5                   10                  15      


Phe Val Lys Cys Gly Tyr Ala Gly Ser Asn Phe Pro Glu His Ile Phe 
            20                  25                  30          


Pro Ala Leu Val Gly Arg Pro Ile Ile Arg Ser Thr Thr Lys Val Gly 
        35                  40                  45              


Asn Ile Glu Ile Lys Asn Asn Lys Lys Met Asp Leu Met Val Gly Asp 
    50                  55                  60                  


Glu Ala Ser Glu Leu Arg Ser Met Leu Glu Val Asn Tyr Pro Met Glu 
65                  70                  75                  80  


Asn Gly Ile Val Arg Asn Trp Asp Asp Met Lys His Leu Trp Asp Tyr 
                85                  90                  95      


Thr Phe Gly Pro Glu Lys Leu Asn Ile Asp Thr Arg Asn Cys Lys Ile 
            100                 105                 110         


Leu Leu Thr Glu Pro Pro Met Asn Pro Thr Lys Asn Arg Glu Lys Ile 
        115                 120                 125             


Val Glu Val Met Phe Glu Thr Tyr Gln Phe Ser Gly Val Tyr Val Ala 
    130                 135                 140                 


Ile Gln Ala Val Leu Thr Leu Tyr Ala Gln Gly Leu Leu Thr Gly Val 
145                 150                 155                 160 


Val Val Asp Ser Gly Asp Gly Val Thr His Ile Cys Pro Val Tyr Glu 
                165                 170                 175     


Gly Phe Ser Leu Pro His Leu Thr Arg Arg Leu Asp Ile Ala Gly Arg 
            180                 185                 190         


Asp Ile Thr Arg Tyr Leu Ile Lys Leu Leu Leu Leu Arg Gly Tyr Ala 
        195                 200                 205             


Phe Asn His Ser Ala Asp Phe Glu Thr Val Arg Met Ile Lys Glu Lys 
    210                 215                 220                 


Leu Cys Tyr Val Gly Tyr Asn Ile Glu Gln Glu Gln Lys Leu Ala Leu 
225                 230                 235                 240 


Glu Thr Thr Val Leu Val Glu Ser Tyr Thr Leu Pro Asp Gly Arg Ile 
                245                 250                 255     


Ile Lys Val Gly Gly Glu Arg Phe Glu Ala Pro Glu Ala Leu Phe Gln 
            260                 265                 270         


Pro His Leu Ile Asn Val Glu Gly Val Gly Val Ala Glu Leu Leu Phe 
        275                 280                 285             


Asn Thr Ile Gln Ala Ala Asp Ile Asp Thr Arg Ser Glu Phe Tyr Lys 
    290                 295                 300                 


His Ile Val Leu Ser Gly Gly Ser Thr Met Tyr Pro Gly Leu Pro Ser 
305                 310                 315                 320 


Arg Leu Glu Arg Glu Leu Lys Gln Leu Tyr Leu Glu Arg Val Leu Lys 
                325                 330                 335     


Gly Asp Val Glu Lys Leu Ser Lys Phe Lys Ile Arg Ile Glu Asp Pro 
            340                 345                 350         


Pro Arg Arg Lys His Met Val Phe Leu Gly Gly Ala Val Leu Ala Asp 
        355                 360                 365             


Ile Met Lys Asp Lys Asp Asn Phe Trp Met Thr Arg Gln Glu Tyr Gln 
    370                 375                 380                 


Glu Lys Gly Val Arg Val Leu Glu Lys Leu Gly Val Thr Val Arg 
385                 390                 395                 


<210>  174
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTR3B__Homo_sapiens__NP_001035225

<400>  174

Met Ala Gly Ser Leu Pro Pro Cys Val Val Asp Cys Gly Thr Gly Tyr 
1               5                   10                  15      


Thr Lys Leu Gly Tyr Ala Gly Asn Thr Glu Pro Gln Phe Ile Ile Pro 
            20                  25                  30          


Ser Cys Ile Ala Ile Arg Glu Ser Ala Lys Val Val Asp Gln Ala Gln 
        35                  40                  45              


Arg Arg Val Leu Arg Gly Val Asp Asp Leu Asp Phe Phe Ile Gly Asp 
    50                  55                  60                  


Glu Ala Ile Asp Lys Pro Thr Tyr Ala Thr Lys Trp Pro Ile Arg His 
65                  70                  75                  80  


Gly Ile Ile Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gln Val 
                85                  90                  95      


Val Phe Lys Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Met 
            100                 105                 110         


Thr Glu Pro Pro Leu Asn Thr Pro Glu Asn Arg Glu Tyr Leu Ala Glu 
        115                 120                 125             


Ile Met Phe Glu Ser Phe Asn Val Pro Gly Leu Tyr Ile Ala Val Gln 
    130                 135                 140                 


Ala Val Leu Ala Leu Ala Ala Ser Trp Thr Ser Arg Gln Val Gly Glu 
145                 150                 155                 160 


Arg Thr Leu Thr Gly Ile Val Ile Asp Ser Gly Asp Gly Val Thr His 
                165                 170                 175     


Val Ile Pro Val Ala Glu Gly Tyr Val Ile Gly Ser Cys Ile Lys His 
            180                 185                 190         


Ile Pro Ile Ala Gly Arg Asp Ile Thr Tyr Phe Ile Gln Gln Leu Leu 
        195                 200                 205             


Arg Glu Arg Glu Val Gly Ile Pro Pro Glu Gln Ser Leu Glu Thr Ala 
    210                 215                 220                 


Lys Ala Ile Lys Glu Lys Tyr Cys Tyr Ile Cys Pro Asp Ile Val Lys 
225                 230                 235                 240 


Glu Phe Ala Lys Tyr Asp Val Asp Pro Arg Lys Trp Ile Lys Gln Tyr 
                245                 250                 255     


Thr Gly Ile Asn Ala Ile Asn Gln Lys Lys Phe Val Ile Asp Val Gly 
            260                 265                 270         


Tyr Glu Arg Phe Leu Gly Pro Glu Ile Phe Phe His Pro Glu Phe Ala 
        275                 280                 285             


Asn Pro Asp Phe Met Glu Ser Ile Ser Asp Val Val Asp Glu Val Ile 
    290                 295                 300                 


Gln Asn Cys Pro Ile Asp Val Arg Arg Pro Leu Tyr Lys Pro Glu Phe 
305                 310                 315                 320 


Phe Gln Val Cys His Thr Lys Lys Asp Tyr Glu Glu Tyr Gly Pro Ser 
                325                 330                 335     


Ile Cys Arg His Asn Pro Val Phe Gly Val Met Ser 
            340                 345             


<210>  175
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTR3__Homo_sapiens__NP_001264069

<400>  175

Met Lys Gly Val Asp Asp Leu Asp Phe Phe Ile Gly Asp Glu Ala Ile 
1               5                   10                  15      


Glu Lys Pro Thr Tyr Ala Thr Lys Trp Pro Ile Arg His Gly Ile Val 
            20                  25                  30          


Glu Asp Trp Asp Leu Met Glu Arg Phe Met Glu Gln Val Ile Phe Lys 
        35                  40                  45              


Tyr Leu Arg Ala Glu Pro Glu Asp His Tyr Phe Leu Leu Thr Glu Pro 
    50                  55                  60                  


Pro Leu Asn Thr Pro Glu Asn Arg Glu Tyr Thr Ala Glu Ile Met Phe 
65                  70                  75                  80  


Glu Ser Phe Asn Val Pro Gly Leu Tyr Ile Ala Val Gln Ala Val Leu 
                85                  90                  95      


Ala Leu Ala Ala Ser Trp Thr Ser Arg Gln Val Gly Glu Arg Thr Leu 
            100                 105                 110         


Thr Gly Thr Val Ile Asp Ser Gly Asp Gly Val Thr His Val Ile Pro 
        115                 120                 125             


Val Ala Glu Gly Tyr Val Ile Gly Ser Cys Ile Lys His Ile Pro Ile 
    130                 135                 140                 


Ala Gly Arg Asp Ile Thr Tyr Phe Ile Gln Gln Leu Leu Arg Asp Arg 
145                 150                 155                 160 


Glu Val Gly Ile Pro Pro Glu Gln Ser Leu Glu Thr Ala Lys Ala Val 
                165                 170                 175     


Lys Glu Arg Tyr Ser Tyr Val Cys Pro Asp Leu Val Lys Glu Phe Asn 
            180                 185                 190         


Lys Tyr Asp Thr Asp Gly Ser Lys Trp Ile Lys Gln Tyr Thr Gly Ile 
        195                 200                 205             


Asn Ala Ile Ser Lys Lys Glu Phe Ser Ile Asp Val Gly Tyr Glu Arg 
    210                 215                 220                 


Phe Leu Gly Pro Glu Ile Phe Phe His Pro Glu Phe Ala Asn Pro Asp 
225                 230                 235                 240 


Phe Thr Gln Pro Ile Ser Glu Val Val Asp Glu Val Ile Gln Asn Cys 
                245                 250                 255     


Pro Ile Asp Val Arg Arg Pro Leu Tyr Lys Asn Ile Val Leu Ser Gly 
            260                 265                 270         


Gly Ser Thr Met Phe Arg Asp Phe Gly Arg Arg Leu Gln Arg Asp Leu 
        275                 280                 285             


Lys Arg Thr Val Asp Ala Arg Leu Lys Leu Ser Glu Glu Leu Ser Gly 
    290                 295                 300                 


Gly Arg Leu Lys Pro Lys Pro Ile Asp Val Gln Val Ile Thr His His 
305                 310                 315                 320 


Met Gln Arg Tyr Ala Val Trp Phe Gly Gly Ser Met Leu Ala Ser Thr 
                325                 330                 335     


Pro Glu Phe Tyr Gln Val Cys His Thr Lys Lys Asp Tyr Glu Glu Ile 
            340                 345                 350         


Gly Pro Ser Ile Cys Arg His Asn Pro Val Phe Gly Val Met Ser 
        355                 360                 365         


<210>  176
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTR5__Homo_sapiens__NP_079131

<400>  176

Met Ala Ala Asn Val Phe Pro Phe Arg Asp Ala Arg Ala Ala Pro Asp 
1               5                   10                  15      


Pro Val Leu Glu Ala Gly Pro Val Ala His Gly Pro Leu Pro Val Pro 
            20                  25                  30          


Leu Val Leu Asp Asn Gly Ser Phe Gln Val Arg Ala Gly Trp Ala Cys 
        35                  40                  45              


Pro Gly Gln Asp Pro Gly Pro Glu Pro Arg Leu Gln Phe Arg Ala Val 
    50                  55                  60                  


Cys Ala Arg Gly Arg Gly Gly Ala Arg Gly Ala Ser Gly Pro Gln Val 
65                  70                  75                  80  


Gly Asn Ala Leu Gly Ser Leu Glu Pro Leu Arg Trp Met Leu Arg Ser 
                85                  90                  95      


Pro Phe Asp Arg Asn Val Pro Val Asn Leu Glu Leu Gln Glu Leu Leu 
            100                 105                 110         


Leu Asp Tyr Ser Phe Gln His Leu Gly Val Ser Ser Gln Gly Cys Val 
        115                 120                 125             


Asp His Pro Ile Val Leu Thr Glu Ala Val Cys Asn Pro Leu Tyr Ser 
    130                 135                 140                 


Arg Gln Met Met Ser Glu Leu Leu Phe Glu Cys Tyr Gly Ile Pro Lys 
145                 150                 155                 160 


Val Ala Tyr Gly Ile Asp Ser Leu Phe Ser Phe Tyr His Asn Lys Pro 
                165                 170                 175     


Lys Asn Ser Met Cys Ser Gly Leu Ile Ile Ser Ser Gly Tyr Gln Cys 
            180                 185                 190         


Thr His Val Leu Pro Ile Leu Glu Gly Arg Leu Asp Ala Lys Asn Cys 
        195                 200                 205             


Lys Arg Ile Asn Leu Gly Gly Ser Gln Ala Ala Gly Tyr Leu Gln Arg 
    210                 215                 220                 


Leu Leu Gln Leu Lys Tyr Pro Gly His Leu Ala Ala Ile Thr Leu Ser 
225                 230                 235                 240 


Arg Met Glu Glu Ile Leu His Glu His Ser Tyr Ile Ala Glu Asp Tyr 
                245                 250                 255     


Val Glu Glu Leu His Lys Trp Arg Cys Pro Asp Tyr Tyr Glu Asn Asn 
            260                 265                 270         


Val His Lys Met Gln Leu Pro Phe Ser Ser Lys Leu Leu Gly Ser Thr 
        275                 280                 285             


Leu Thr Ser Glu Glu Lys Gln Glu Arg Arg Gln Gln Gln Leu Arg Arg 
    290                 295                 300                 


Leu Gln Glu Leu Asn Ala Arg Arg Arg Glu Glu Lys Leu Gln Leu Asp 
305                 310                 315                 320 


Gln Glu Arg Leu Asp Arg Leu Leu Tyr Val Gln Glu Leu Leu Glu Asp 
                325                 330                 335     


Gly Gln Met Asp Gln Phe His Lys Ala Leu Ile Glu Leu Asn Met Asp 
            340                 345                 350         


Ser Pro Glu Glu Leu Gln Ser Tyr Ile Gln Lys Leu Ser Ile Ala Val 
        355                 360                 365             


Glu Gln Ala Lys Gln Lys Ile Leu Gln Ala Glu Val Asn Leu Glu Val 
    370                 375                 380                 


Asp Val Val Asp Ser Lys Pro Glu Thr Pro Asp Leu Glu Gln Leu Glu 
385                 390                 395                 400 


Pro Ser Leu Glu Asp Val Glu Ser Met Asn Asp Phe Asp Pro Leu Phe 
                405                 410                 415     


Ser Glu Glu Thr Pro Gly Val Glu Lys Pro Val Thr Thr Val Gln Pro 
            420                 425                 430         


Val Phe Asn Leu Ala Ala Tyr His Gln Leu Phe Val Gly Thr Glu Arg 
        435                 440                 445             


Ile Arg Ala Pro Glu Ile Ile Phe Gln Pro Ser Leu Ile Gly Glu Glu 
    450                 455                 460                 


Gln Ala Gly Ile Ala Glu Thr Leu Gln Tyr Ile Leu Asp Arg Tyr Pro 
465                 470                 475                 480 


Lys Asp Ile Gln Glu Met Leu Val Gln Asn Val Phe Leu Thr Gly Gly 
                485                 490                 495     


Asn Thr Met Tyr Pro Gly Met Lys Ala Arg Met Glu Lys Glu Leu Leu 
            500                 505                 510         


Glu Met Arg Pro Phe Arg Ser Ser Phe Gln Val Gln Leu Ala Ser Asn 
        515                 520                 525             


Pro Val Leu Asp Ala Trp Tyr Gly Ala Arg Asp Trp Ala Leu Asn His 
    530                 535                 540                 


Leu Asp Asp Asn Glu Val Trp Ile Thr Arg Lys Glu Tyr Glu Glu Lys 
545                 550                 555                 560 


Gly Gly Glu Tyr Leu Lys Glu His Cys Ala Ser Asn Ile Tyr Val Pro 
                565                 570                 575     


Ile Arg Leu Pro Lys Gln Ala Ser Arg Ser Ser Asp Ala Gln Ala Ser 
            580                 585                 590         


Ser Lys Gly Ser Ala Ala Gly Gly Gly Gly Ala Gly Glu Gln Ala 
        595                 600                 605         


<210>  177
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACTRT1__Homo_sapiens__NP_612146

<400>  177

Met Phe Asn Pro His Ala Leu Asp Val Pro Ala Val Ile Phe Asp Asn 
1               5                   10                  15      


Gly Ser Gly Leu Cys Lys Ala Gly Leu Ser Gly Glu Ile Gly Pro Arg 
            20                  25                  30          


His Val Ile Ser Ser Val Leu Gly His Cys Lys Phe Asn Val Pro Leu 
        35                  40                  45              


Ala Arg Leu Asn Gln Lys Tyr Phe Val Gly Gln Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Tyr Glu Ala Leu His Leu His Tyr Pro Ile Glu Arg Gly Leu Val Thr 
65                  70                  75                  80  


Gly Trp Asp Asp Met Glu Lys Leu Trp Lys His Leu Phe Glu Arg Glu 
                85                  90                  95      


Leu Gly Val Lys Pro Ser Gln Gln Pro Val Leu Met Thr Glu Pro Ser 
            100                 105                 110         


Leu Asn Pro Arg Glu Ile Arg Glu Lys Leu Ala Glu Met Met Phe Glu 
        115                 120                 125             


Thr Phe Ser Val Pro Gly Phe Tyr Leu Ser Asn His Ala Val Ala Ala 
    130                 135                 140                 


Leu Tyr Ala Ser Ala Cys Val Thr Gly Leu Val Val Asp Ser Gly Asp 
145                 150                 155                 160 


Gly Val Thr Cys Thr Val Pro Ile Phe Glu Gly Tyr Ser Leu Pro His 
                165                 170                 175     


Ala Val Thr Lys Leu Cys Met Ala Gly Arg Asp Ile Thr Glu His Leu 
            180                 185                 190         


Thr Arg Leu Leu Phe Ala Ser Gly Phe Asn Phe Pro Cys Ile Leu Asn 
        195                 200                 205             


Lys Ala Val Val Asn Asn Ile Lys Glu Lys Leu Cys Tyr Ile Ala Leu 
    210                 215                 220                 


Glu Pro Glu Lys Glu Leu Arg Lys Ser Arg Gly Glu Val Leu Gly Ala 
225                 230                 235                 240 


Tyr Arg Leu Pro Asp Gly His Val Ile His Phe Gly Asp Glu Leu Tyr 
                245                 250                 255     


Gln Val Pro Glu Val Leu Phe Ala Pro Asp Gln Leu Gly Ile His Ser 
            260                 265                 270         


Pro Gly Leu Ser Lys Met Val Ser Ser Ser Ile Met Lys Cys Asp Thr 
        275                 280                 285             


Asp Ile Gln Asn Lys Leu Tyr Ala Asp Ile Val Leu Ser Gly Gly Thr 
    290                 295                 300                 


Thr Leu Leu Pro Gly Leu Glu Glu Arg Leu Met Lys Glu Val Glu Gln 
305                 310                 315                 320 


Leu Ala Ser Lys Gly Thr Pro Ile Lys Ile Thr Ala Ser Pro Asp Arg 
                325                 330                 335     


Cys Phe Ser Ala Trp Ile Gly Ala Ser Ile Met Thr Ser Met Ser Ser 
            340                 345                 350         


Phe Lys Gln Met Trp Val Thr Ser Ala Asp Phe Lys Glu Tyr Gly Thr 
        355                 360                 365             


Ser Val Val Gln Arg Arg Cys Phe 
    370                 375     


<210>  178
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACVR1B__Homo_sapiens__NP_004293

<400>  178

Met Ala Glu Ser Ala Gly Ala Ser Ser Phe Phe Pro Leu Val Val Leu 
1               5                   10                  15      


Leu Leu Ala Gly Ser Gly Gly Ser Gly Pro Arg Gly Val Gln Ala Leu 
            20                  25                  30          


Leu Cys Ala Cys Thr Ser Cys Leu Gln Ala Asn Tyr Thr Cys Glu Thr 
        35                  40                  45              


Asp Gly Ala Cys Met Val Ser Ile Phe Asn Leu Asp Gly Met Glu His 
    50                  55                  60                  


His Val Arg Thr Cys Ile Pro Lys Val Glu Leu Val Pro Ala Gly Lys 
65                  70                  75                  80  


Pro Phe Tyr Cys Leu Ser Ser Glu Asp Leu Arg Asn Thr His Cys Cys 
                85                  90                  95      


Tyr Thr Asp Tyr Cys Asn Arg Ile Asp Leu Arg Val Pro Ser Gly His 
            100                 105                 110         


Leu Lys Glu Pro Glu His Pro Ser Met Trp Gly Pro Val Glu Leu Val 
        115                 120                 125             


Gly Ile Ile Ala Gly Pro Val Phe Leu Leu Phe Leu Ile Ile Ile Ile 
    130                 135                 140                 


Val Phe Leu Val Ile Asn Tyr His Gln Arg Val Tyr His Asn Arg Gln 
145                 150                 155                 160 


Arg Leu Asp Met Glu Asp Pro Ser Cys Glu Met Cys Leu Ser Lys Asp 
                165                 170                 175     


Lys Thr Leu Gln Asp Leu Val Tyr Asp Leu Ser Thr Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Leu Pro Leu Phe Val Gln Arg Thr Val Ala Arg Thr Ile Val 
        195                 200                 205             


Leu Gln Glu Ile Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly 
    210                 215                 220                 


Arg Trp Arg Gly Gly Asp Val Ala Val Lys Ile Phe Ser Ser Arg Glu 
225                 230                 235                 240 


Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu 
                245                 250                 255     


Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn 
            260                 265                 270         


Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly 
        275                 280                 285             


Ser Leu Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Ile Glu Gly Met 
    290                 295                 300                 


Ile Lys Leu Ala Leu Ser Ala Ala Ser Gly Leu Ala His Leu His Met 
305                 310                 315                 320 


Glu Ile Val Gly Thr Gln Gly Lys Pro Gly Ile Ala His Arg Asp Leu 
                325                 330                 335     


Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Met Cys Ala Ile Ala 
            340                 345                 350         


Asp Leu Gly Leu Ala Val Arg His Asp Ala Val Thr Asp Thr Ile Asp 
        355                 360                 365             


Ile Ala Pro Asn Gln Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu 
    370                 375                 380                 


Val Leu Asp Glu Thr Ile Asn Met Lys His Phe Asp Ser Phe Lys Cys 
385                 390                 395                 400 


Ala Asp Ile Tyr Ala Leu Gly Leu Val Tyr Trp Glu Ile Ala Arg Arg 
                405                 410                 415     


Cys Asn Ser Gly Gly Val His Glu Glu Tyr Gln Leu Pro Tyr Tyr Asp 
            420                 425                 430         


Leu Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val Val Cys 
        435                 440                 445             


Asp Gln Lys Leu Arg Pro Asn Ile Pro Asn Trp Trp Gln Ser Tyr Glu 
    450                 455                 460                 


Ala Leu Arg Val Met Gly Lys Met Met Arg Glu Cys Trp Tyr Ala Asn 
465                 470                 475                 480 


Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln 
                485                 490                 495     


Leu Ser Val Gln Glu Asp Val Lys Ile 
            500                 505 


<210>  179
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACVR1C__Homo_sapiens__NP_001104501

<400>  179

Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val Ser Leu 
1               5                   10                  15      


Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn Val Thr 
            20                  25                  30          


Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr Leu His 
        35                  40                  45              


Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met Glu Leu 
    50                  55                  60                  


Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala Ala Met 
65                  70                  75                  80  


Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg Lys Lys 
                85                  90                  95      


Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu Val Asn 
            100                 105                 110         


Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala Ser Gly 
        115                 120                 125             


Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr 
    130                 135                 140                 


Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu Val Trp 
145                 150                 155                 160 


His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe Ser Ser 
                165                 170                 175     


Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val 
            180                 185                 190         


Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys 
        195                 200                 205             


Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr His Glu 
    210                 215                 220                 


Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr Val Ala 
225                 230                 235                 240 


Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala His Leu 
                245                 250                 255     


His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg 
            260                 265                 270         


Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr Cys Ala 
        275                 280                 285             


Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu Asn Thr 
    290                 295                 300                 


Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr Met Ala 
305                 310                 315                 320 


Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu Ser Phe 
                325                 330                 335     


Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu Ile Ala 
            340                 345                 350         


Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr 
        355                 360                 365             


Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg Lys Val 
    370                 375                 380                 


Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp Gln Ser 
385                 390                 395                 400 


Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys Trp Tyr 
                405                 410                 415     


Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Ile 
            420                 425                 430         


Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
        435                 440             


<210>  180
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACVR1__Homo_sapiens__NP_001096

<400>  180

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  181
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACVR2A__Homo_sapiens__NP_001265508

<400>  181

Met Gly Ala Ala Ala Lys Leu Ala Phe Ala Val Phe Leu Ile Ser Cys 
1               5                   10                  15      


Ser Ser Gly Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe 
            20                  25                  30          


Phe Asn Ala Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu 
        35                  40                  45              


Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp 
    50                  55                  60                  


Lys Asn Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu 
65                  70                  75                  80  


Asp Asp Ile Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp 
                85                  90                  95      


Ser Pro Glu Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu 
            100                 105                 110         


Lys Phe Ser Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn 
        115                 120                 125             


Pro Val Thr Pro Lys Pro Pro Tyr Tyr Asn Ile Leu Leu Tyr Ser Leu 
    130                 135                 140                 


Val Pro Leu Met Leu Ile Ala Gly Ile Val Ile Cys Ala Phe Trp Val 
145                 150                 155                 160 


Tyr Arg His His Lys Met Ala Tyr Pro Pro Val Leu Val Pro Thr Gln 
                165                 170                 175     


Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Leu Gly Leu Lys Pro Leu 
            180                 185                 190         


Gln Leu Leu Glu Val Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys 
        195                 200                 205             


Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile Phe Pro Ile Gln 
    210                 215                 220                 


Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Val Tyr Ser Leu Pro Gly 
225                 230                 235                 240 


Met Lys His Glu Asn Ile Leu Gln Phe Ile Gly Ala Glu Lys Arg Gly 
                245                 250                 255     


Thr Ser Val Asp Val Asp Leu Trp Leu Ile Thr Ala Phe His Glu Lys 
            260                 265                 270         


Gly Ser Leu Ser Asp Phe Leu Lys Ala Asn Val Val Ser Trp Asn Glu 
        275                 280                 285             


Leu Cys His Ile Ala Glu Thr Met Ala Arg Gly Leu Ala Tyr Leu His 
    290                 295                 300                 


Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro Ala Ile Ser His 
305                 310                 315                 320 


Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn Asn Leu Thr Ala 
                325                 330                 335     


Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu Ala Gly Lys Ser 
            340                 345                 350         


Ala Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro 
        355                 360                 365             


Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg 
    370                 375                 380                 


Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Ala Ser Arg 
385                 390                 395                 400 


Cys Thr Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu 
                405                 410                 415     


Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met Gln Glu Val Val 
            420                 425                 430         


Val His Lys Lys Lys Arg Pro Val Leu Arg Asp Tyr Trp Gln Lys His 
        435                 440                 445             


Ala Gly Met Ala Met Leu Cys Glu Thr Ile Glu Glu Cys Trp Asp His 
    450                 455                 460                 


Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Gly Glu Arg Ile Thr 
465                 470                 475                 480 


Gln Met Gln Arg Leu Thr Asn Ile Ile Thr Thr Glu Asp Ile Val Thr 
                485                 490                 495     


Val Val Thr Met Val Thr Asn Val Asp Phe Pro Pro Lys Glu Ser Ser 
            500                 505                 510         


Leu 
    


<210>  182
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACVR2B__Homo_sapiens__NP_001097

<400>  182

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  183
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACVRL1__Homo_sapiens__NP_001070869

<400>  183

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
            260                 265                 270         


Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
        435                 440                 445             


Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210>  184
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACY1__Homo_sapiens__NP_001185824

<400>  184

Met Thr Ser Lys Gly Pro Glu Glu Glu His Pro Ser Val Thr Leu Phe 
1               5                   10                  15      


Arg Gln Tyr Leu Arg Ile Arg Thr Val Gln Pro Lys Pro Asp Tyr Gly 
            20                  25                  30          


Ala Ala Val Ala Phe Phe Glu Glu Thr Ala Arg Gln Leu Gly Leu Gly 
        35                  40                  45              


Cys Gln Lys Val Glu Val Ala Pro Gly Tyr Val Val Thr Val Leu Thr 
    50                  55                  60                  


Trp Pro Gly Thr Asn Pro Thr Leu Ser Ser Ile Leu Leu Asn Ser His 
65                  70                  75                  80  


Thr Asp Val Val Pro Val Phe Lys Glu His Trp Ser His Asp Pro Phe 
                85                  90                  95      


Glu Ala Phe Lys Asp Ser Glu Gly Tyr Ile Tyr Ala Arg Gly Ala Gln 
            100                 105                 110         


Asp Met Lys Cys Val Ser Ile Gln Tyr Leu Glu Ala Val Arg Arg Leu 
        115                 120                 125             


Lys Val Glu Gly His Arg Phe Pro Arg Thr Ile His Met Thr Phe Val 
    130                 135                 140                 


Pro Asp Glu Glu Val Gly Gly His Gln Gly Met Glu Leu Phe Val Gln 
145                 150                 155                 160 


Arg Pro Glu Phe His Ala Leu Arg Ala Gly Phe Ala Leu Asp Glu Gly 
                165                 170                 175     


Ile Ala Asn Pro Thr Asp Ala Phe Thr Val Phe Tyr Ser Glu Arg Ser 
            180                 185                 190         


Pro Trp Trp Val Arg Val Thr Ser Thr Gly Arg Pro Gly His Ala Ser 
        195                 200                 205             


Arg Phe Met Glu Asp Thr Ala Ala Glu Lys Leu His Lys Val Val Asn 
    210                 215                 220                 


Ser Ile Leu Ala Phe Arg Glu Lys Glu Trp Gln Arg Leu Gln Ser Asn 
225                 230                 235                 240 


Pro His Leu Lys Glu Gly Ser Val Thr Ser Val Asn Leu Thr Lys Leu 
                245                 250                 255     


Glu Gly Gly Val Ala Tyr Asn Val Ile Pro Ala Thr Met Ser Ala Ser 
            260                 265                 270         


Phe Asp Phe Arg Val Ala Pro Asp Val Asp Phe Lys Ala Phe Glu Glu 
        275                 280                 285             


Gln Leu Gln Ser Trp Cys Gln Ala Ala Gly Glu Gly Val Thr Leu Glu 
    290                 295                 300                 


Phe Ala Gln Lys Trp Met His Pro Gln Val Thr Pro Thr Asp Asp Ser 
305                 310                 315                 320 


Asn Pro Trp Trp Ala Ala Phe Ser Arg Val Cys Lys Asp Met Asn Leu 
                325                 330                 335     


Thr Leu Glu Pro Glu Ile Met Pro Ala Ala Thr Asp Asn Arg Tyr Ile 
            340                 345                 350         


Arg Ala Val Gly Val Pro Ala Leu Gly Phe Ser Pro Met Asn Arg Thr 
        355                 360                 365             


Pro Val Leu Leu His Asp His Asp Glu Arg Leu His Glu Ala Val Phe 
    370                 375                 380                 


Leu Arg Gly Val Asp Ile Tyr Thr Arg Leu Leu Pro Ala Leu Ala Ser 
385                 390                 395                 400 


Val Pro Ala Leu Pro Ser Asp Ser 
                405             


<210>  185
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACY3__Homo_sapiens__NP_542389

<400>  185

Met Cys Ser Leu Pro Val Pro Arg Glu Pro Leu Arg Arg Val Ala Val 
1               5                   10                  15      


Thr Gly Gly Thr His Gly Asn Glu Met Ser Gly Val Tyr Leu Ala Arg 
            20                  25                  30          


His Trp Leu His Ala Pro Ala Glu Leu Gln Arg Ala Ser Phe Ser Ala 
        35                  40                  45              


Val Pro Val Leu Ala Asn Pro Ala Ala Thr Ser Gly Cys Arg Arg Tyr 
    50                  55                  60                  


Val Asp His Asp Leu Asn Arg Thr Phe Thr Ser Ser Phe Leu Asn Ser 
65                  70                  75                  80  


Arg Pro Thr Pro Asp Asp Pro Tyr Glu Val Thr Arg Ala Arg Glu Leu 
                85                  90                  95      


Asn Gln Leu Leu Gly Pro Lys Ala Ser Gly Gln Ala Phe Asp Phe Val 
            100                 105                 110         


Leu Asp Leu His Asn Thr Thr Ala Asn Met Gly Thr Cys Leu Ile Ala 
        115                 120                 125             


Lys Ser Ser His Glu Val Phe Ala Met His Leu Cys Arg His Leu Gln 
    130                 135                 140                 


Leu Gln Tyr Pro Glu Leu Ser Cys Gln Val Phe Leu Tyr Gln Arg Ser 
145                 150                 155                 160 


Gly Glu Glu Ser Tyr Asn Leu Asp Ser Val Ala Lys Asn Gly Leu Gly 
                165                 170                 175     


Leu Glu Leu Gly Pro Gln Pro Gln Gly Val Leu Arg Ala Asp Ile Phe 
            180                 185                 190         


Ser Arg Met Arg Thr Leu Val Ala Thr Val Leu Asp Phe Ile Glu Leu 
        195                 200                 205             


Phe Asn Gln Gly Thr Ala Phe Pro Ala Phe Glu Met Glu Ala Tyr Arg 
    210                 215                 220                 


Pro Val Gly Val Val Asp Phe Pro Arg Thr Glu Ala Gly His Leu Ala 
225                 230                 235                 240 


Gly Thr Val His Pro Gln Leu Gln Asp Arg Asp Phe Gln Pro Leu Gln 
                245                 250                 255     


Pro Gly Ala Pro Ile Phe Gln Met Phe Ser Gly Glu Asp Leu Leu Tyr 
            260                 265                 270         


Glu Gly Glu Ser Thr Val Tyr Pro Val Phe Ile Asn Glu Ala Ala Tyr 
        275                 280                 285             


Tyr Glu Lys Gly Val Ala Phe Val Gln Thr Glu Lys Phe Thr Phe Thr 
    290                 295                 300                 


Val Pro Ala Met Pro Ala Leu Thr Pro Ala Pro Ser Pro Ala Ser 
305                 310                 315                 


<210>  186
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACYP2__Homo_sapiens__NP_612457

<400>  186

Met Ser Thr Ala Gln Ser Leu Lys Ser Val Asp Tyr Glu Val Phe Gly 
1               5                   10                  15      


Arg Val Gln Gly Val Cys Phe Arg Met Tyr Thr Glu Asp Glu Ala Arg 
            20                  25                  30          


Lys Ile Gly Val Val Gly Trp Val Lys Asn Thr Ser Lys Gly Thr Val 
        35                  40                  45              


Thr Gly Gln Val Gln Gly Pro Glu Asp Lys Val Asn Ser Met Lys Ser 
    50                  55                  60                  


Trp Leu Ser Lys Val Gly Ser Pro Ser Ser Arg Ile Asp Arg Thr Asn 
65                  70                  75                  80  


Phe Ser Asn Glu Lys Thr Ile Ser Lys Leu Glu Tyr Ser Asn Phe Ser 
                85                  90                  95      


Ile Arg Tyr 
            


<210>  187
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAD1__Homo_sapiens__NP_001152757

<400>  187

Met Ala Ser Asn Asn His Trp Phe Gln Ser Ser Gln Val Pro Ser Phe 
1               5                   10                  15      


Ala Gln Met Leu Lys Lys Asn Leu Pro Val Gln Pro Ala Thr Lys Thr 
            20                  25                  30          


Ile Thr Thr Pro Thr Gly Trp Ser Ser Glu Ser Tyr Gly Leu Ser Lys 
        35                  40                  45              


Met Ala Ser Lys Val Thr Gln Val Thr Gly Asn Phe Pro Glu Pro Leu 
    50                  55                  60                  


Leu Ser Lys Asn Leu Ser Ser Ile Ser Asn Pro Val Leu Pro Pro Lys 
65                  70                  75                  80  


Lys Ile Pro Lys Glu Phe Ile Met Lys Tyr Lys Arg Gly Glu Ile Asn 
                85                  90                  95      


Pro Val Ser Ala Leu His Gln Phe Ala Gln Met Gln Arg Val Gln Leu 
            100                 105                 110         


Asp Leu Lys Glu Thr Val Thr Thr Gly Asn Val Met Gly Pro Tyr Phe 
        115                 120                 125             


Ala Phe Cys Ala Val Val Asp Gly Ile Gln Tyr Lys Thr Gly Leu Gly 
    130                 135                 140                 


Gln Asn Lys Lys Glu Ser Arg Ser Asn Ala Ala Lys Leu Ala Leu Asp 
145                 150                 155                 160 


Glu Leu Leu Gln Leu Asp Glu Pro Glu Pro Arg Ile Leu Glu Thr Ser 
                165                 170                 175     


Gly Pro Pro Pro Phe Pro Ala Glu Pro Val Val Leu Ser Glu Leu Ala 
            180                 185                 190         


Tyr Val Ser Lys Val His Tyr Glu Gly Arg His Ile Gln Tyr Ala Lys 
        195                 200                 205             


Ile Ser Gln Ile Val Lys Glu Arg Phe Asn Gln Leu Ile Ser Asn Arg 
    210                 215                 220                 


Ser Glu Tyr Leu Lys Tyr Ser Ser Ser Leu Ala Ala Phe Ile Ile Glu 
225                 230                 235                 240 


Arg Ala Gly Gln His Glu Val Val Ala Ile Gly Thr Gly Glu Tyr Asn 
                245                 250                 255     


Tyr Ser Gln Asp Ile Lys Pro Asp Gly Arg Val Leu His Asp Thr His 
            260                 265                 270         


Ala Val Val Thr Ala Arg Arg Ser Leu Leu Ser Lys Asn Pro Ala Met 
        275                 280                 285             


Met Glu Lys Ser Ile Phe Cys Thr Glu Pro Thr Ser Asn Leu Leu Thr 
    290                 295                 300                 


Leu Lys Gln Asn Ile Asn Ile Cys Leu Tyr Met Asn Gln Leu Pro Lys 
305                 310                 315                 320 


Gly Ser Ala Gln Ile Lys Ser Gln Leu Arg Leu Asn Pro His Ser Ile 
                325                 330                 335     


Ser Ala Phe Glu Ala Asn Glu Glu Leu Cys Leu His Val Ala Val Glu 
            340                 345                 350         


Gly Lys Ile Tyr Leu Thr Val Tyr Cys Pro Lys Asp Gly Val Asn Arg 
        355                 360                 365             


Ile Ser Ser Met Ser Ser Ser Asp Lys Leu Thr Arg Trp Glu Val Leu 
    370                 375                 380                 


Gly Val Gln Gly Ala Leu Leu Ser His Phe Ile Gln Pro Val Tyr Ile 
385                 390                 395                 400 


Ser Ser Ile Leu Ile Gly Asp Gly Asn Cys Ser Asp Thr Arg Gly Leu 
                405                 410                 415     


Glu Ile Ala Ile Lys Gln Arg Val Asp Asp Ala Leu Thr Ser Lys Leu 
            420                 425                 430         


Pro Met Phe Tyr Leu Val Asn Arg Pro His Ile Ser Leu Val Pro Ser 
        435                 440                 445             


Ala Tyr Pro Leu Gln Met Asn Leu Glu Tyr Lys Phe Leu Ser Leu Asn 
    450                 455                 460                 


Trp Ala Gln Gly Asp Val Ser Leu Glu Ile Val Asp Gly Leu Ser Gly 
465                 470                 475                 480 


Lys Ile Thr Glu Ser Ser Pro Phe Lys Ser Gly Met Ser Met Ala Ser 
                485                 490                 495     


Arg Leu Cys Lys Ala Ala Met Leu Ser Arg Phe Asn Leu Leu Ala Lys 
            500                 505                 510         


Glu Ala Lys Lys Glu Leu Leu Glu Ala Gly Thr Tyr His Ala Ala Lys 
        515                 520                 525             


Cys Met Ser Ala Ser Tyr Gln Glu Ala Lys Cys Lys Leu Lys Ser Tyr 
    530                 535                 540                 


Leu Gln Gln His Gly Tyr Gly Ser Trp Ile Val Lys Ser Pro Cys Ile 
545                 550                 555                 560 


Glu Gln Phe Asn Met 
                565 


<210>  188
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADA__Homo_sapiens__NP_000013

<400>  188

Met Ala Gln Thr Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Thr Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Thr Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Thr Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Gly Cys Arg Glu Ala Ile Lys 
65                  70                  75                  80  


Arg Ile Ala Tyr Glu Phe Val Glu Met Lys Ala Lys Glu Gly Val Val 
                85                  90                  95      


Tyr Val Glu Val Arg Tyr Ser Pro His Leu Leu Ala Asn Ser Lys Val 
            100                 105                 110         


Glu Pro Ile Pro Trp Asn Gln Ala Glu Gly Asp Leu Thr Pro Asp Glu 
        115                 120                 125             


Val Val Ala Leu Val Gly Gln Gly Leu Gln Glu Gly Glu Arg Asp Phe 
    130                 135                 140                 


Gly Val Lys Ala Arg Ser Ile Leu Cys Cys Met Arg His Gln Pro Asn 
145                 150                 155                 160 


Trp Ser Pro Lys Val Val Glu Leu Cys Lys Lys Tyr Gln Gln Gln Thr 
                165                 170                 175     


Val Val Ala Ile Asp Leu Ala Gly Asp Glu Thr Ile Pro Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly His Val Gln Ala Tyr Gln Glu Ala Val Lys Ser Gly 
        195                 200                 205             


Ile His Arg Thr Val His Ala Gly Glu Val Gly Ser Ala Glu Val Val 
    210                 215                 220                 


Lys Glu Ala Val Asp Ile Leu Lys Thr Glu Arg Leu Gly His Gly Tyr 
225                 230                 235                 240 


His Thr Leu Glu Asp Gln Ala Leu Tyr Asn Arg Leu Arg Gln Glu Asn 
                245                 250                 255     


Met His Phe Glu Ile Cys Pro Trp Ser Ser Tyr Leu Thr Gly Ala Trp 
            260                 265                 270         


Lys Pro Asp Thr Glu His Ala Val Ile Arg Leu Lys Asn Asp Gln Ala 
        275                 280                 285             


Asn Tyr Ser Leu Asn Thr Asp Asp Pro Leu Ile Phe Lys Ser Thr Leu 
    290                 295                 300                 


Asp Thr Asp Tyr Gln Met Thr Lys Arg Asp Met Gly Phe Thr Glu Glu 
305                 310                 315                 320 


Glu Phe Lys Arg Leu Asn Ile Asn Ala Ala Lys Ser Ser Phe Leu Pro 
                325                 330                 335     


Glu Asp Glu Lys Arg Glu Leu Leu Asp Leu Leu Tyr Lys Ala Tyr Gly 
            340                 345                 350         


Met Pro Pro Ser Ala Ser Ala Gly Gln Asn Leu 
        355                 360             


<210>  189
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM10__Homo_sapiens__NP_001101

<400>  189

Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu 
            180                 185                 190         


Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile 
                245                 250                 255     


Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala 
        595                 600                 605             


Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile 
    610                 615                 620                 


Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210>  190
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM11__Homo_sapiens__NP_002381

<400>  190

Met Arg Leu Leu Arg Arg Trp Ala Phe Ala Ala Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Pro Thr Pro Gly Leu Gly Thr Gln Gly Pro Ala Gly Ala Leu Arg 
            20                  25                  30          


Trp Gly Gly Leu Pro Gln Leu Gly Gly Pro Gly Ala Pro Glu Val Thr 
        35                  40                  45              


Glu Pro Ser Arg Leu Val Arg Glu Ser Ser Gly Gly Glu Val Arg Lys 
    50                  55                  60                  


Gln Gln Leu Asp Thr Arg Val Arg Gln Glu Pro Pro Gly Gly Pro Pro 
65                  70                  75                  80  


Val His Leu Ala Gln Val Ser Phe Val Ile Pro Ala Phe Asn Ser Asn 
                85                  90                  95      


Phe Thr Leu Asp Leu Glu Leu Asn His His Leu Leu Ser Ser Gln Tyr 
            100                 105                 110         


Val Glu Arg His Phe Ser Arg Glu Gly Thr Thr Gln His Ser Thr Gly 
        115                 120                 125             


Ala Gly Asp His Cys Tyr Tyr Gln Gly Lys Leu Arg Gly Asn Pro His 
    130                 135                 140                 


Ser Phe Ala Ala Leu Ser Thr Cys Gln Gly Leu His Gly Val Phe Ser 
145                 150                 155                 160 


Asp Gly Asn Leu Thr Tyr Ile Val Glu Pro Gln Glu Val Ala Gly Pro 
                165                 170                 175     


Trp Gly Ala Pro Gln Gly Pro Leu Pro His Leu Ile Tyr Arg Thr Pro 
            180                 185                 190         


Leu Leu Pro Asp Pro Leu Gly Cys Arg Glu Pro Gly Cys Leu Phe Ala 
        195                 200                 205             


Val Pro Ala Gln Ser Ala Pro Pro Asn Arg Pro Arg Leu Arg Arg Lys 
    210                 215                 220                 


Arg Gln Val Arg Arg Gly His Pro Thr Val His Ser Glu Thr Lys Tyr 
225                 230                 235                 240 


Val Glu Leu Ile Val Ile Asn Asp His Gln Leu Phe Glu Gln Met Arg 
                245                 250                 255     


Gln Ser Val Val Leu Thr Ser Asn Phe Ala Lys Ser Val Val Asn Leu 
            260                 265                 270         


Ala Asp Val Ile Tyr Lys Glu Gln Leu Asn Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Asp Gly Asp Lys Ile Gln Val Gln Asp Asp 
    290                 295                 300                 


Leu Leu Glu Thr Leu Ala Arg Leu Met Val Tyr Arg Arg Glu Gly Leu 
305                 310                 315                 320 


Pro Glu Pro Ser Asp Ala Thr His Leu Phe Ser Gly Arg Thr Phe Gln 
                325                 330                 335     


Ser Thr Ser Ser Gly Ala Ala Tyr Val Gly Gly Ile Cys Ser Leu Ser 
            340                 345                 350         


His Gly Gly Gly Val Asn Glu Tyr Gly Asn Met Gly Ala Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Thr Leu Gly Gln Asn Leu Gly Met Met Trp Asn Lys 
    370                 375                 380                 


His Arg Ser Ser Ala Gly Asp Cys Lys Cys Pro Asp Ile Trp Leu Gly 
385                 390                 395                 400 


Cys Ile Met Glu Asp Thr Gly Phe Tyr Leu Pro Arg Lys Phe Ser Arg 
                405                 410                 415     


Cys Ser Ile Asp Glu Tyr Asn Gln Phe Leu Gln Glu Gly Gly Gly Ser 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Leu Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp Cys Gly Ser Val Gln 
    450                 455                 460                 


Glu Cys Ser Arg Ala Gly Gly Asn Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


His Asp Ala Met Cys Ser Asp Gly Leu Cys Cys Arg Arg Cys Lys Tyr 
                485                 490                 495     


Glu Pro Arg Gly Val Ser Cys Arg Glu Ala Val Asn Glu Cys Asp Ile 
            500                 505                 510         


Ala Glu Thr Cys Thr Gly Asp Ser Ser Gln Cys Pro Pro Asn Leu His 
        515                 520                 525             


Lys Leu Asp Gly Tyr Tyr Cys Asp His Glu Gln Gly Arg Cys Tyr Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Gln Val Leu Trp Gly His 
545                 550                 555                 560 


Ala Ala Ala Asp Arg Phe Cys Tyr Glu Lys Leu Asn Val Glu Gly Thr 
                565                 570                 575     


Glu Arg Gly Ser Cys Gly Arg Lys Gly Ser Gly Trp Val Gln Cys Ser 
            580                 585                 590         


Lys Gln Asp Val Leu Cys Gly Phe Leu Leu Cys Val Asn Ile Ser Gly 
        595                 600                 605             


Ala Pro Arg Leu Gly Asp Leu Val Gly Asp Ile Ser Ser Val Thr Phe 
    610                 615                 620                 


Tyr His Gln Gly Lys Glu Leu Asp Cys Arg Gly Gly His Val Gln Leu 
625                 630                 635                 640 


Ala Asp Gly Ser Asp Leu Ser Tyr Val Glu Asp Gly Thr Ala Cys Gly 
                645                 650                 655     


Pro Asn Met Leu Cys Leu Asp His Arg Cys Leu Pro Ala Ser Ala Phe 
            660                 665                 670         


Asn Phe Ser Thr Cys Pro Gly Ser Gly Glu Arg Arg Ile Cys Ser His 
        675                 680                 685             


His Gly Val Cys Ser Asn Glu Gly Lys Cys Ile Cys Gln Pro Asp Trp 
    690                 695                 700                 


Thr Gly Lys Asp Cys Ser Ile His Asn Pro Leu Pro Thr Ser Pro Pro 
705                 710                 715                 720 


Thr Gly Glu Thr Glu Arg Tyr Lys Gly Pro Ser Gly Thr Asn Ile Ile 
                725                 730                 735     


Ile Gly Ser Ile Ala Gly Ala Val Leu Val Ala Ala Ile Val Leu Gly 
            740                 745                 750         


Gly Thr Gly Trp Gly Phe Lys Asn Ile Arg Arg Gly Arg Ser Gly Gly 
        755                 760                 765             


Ala 
    


<210>  191
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM12__Homo_sapiens__NP_001275904

<400>  191

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr Ser Asp Ser 
        115                 120                 125             


Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu Ile Val Phe 
    130                 135                 140                 


Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala Thr Asn Arg 
145                 150                 155                 160 


Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg Gly Ser Cys 
                165                 170                 175     


Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn Val Phe Pro 
            180                 185                 190         


Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu Thr Leu Lys 
        195                 200                 205             


Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn Arg Glu Phe 
    210                 215                 220                 


Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg Leu Ile Glu 
225                 230                 235                 240 


Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn Ile Arg Ile 
                245                 250                 255     


Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys Cys Ser Val 
            260                 265                 270         


Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp Trp Arg Lys 
        275                 280                 285             


Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln Leu Val Ser 
    290                 295                 300                 


Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro Ile Met Ser 
305                 310                 315                 320 


Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp His Ser Asp 
                325                 330                 335     


Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser Cys Gln Met 
        355                 360                 365             


Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr Gly Tyr Pro 
    370                 375                 380                 


Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu Glu Thr Ser 
385                 390                 395                 400 


Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro Glu Val Arg 
                405                 410                 415     


Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val Glu Glu Gly 
            420                 425                 430         


Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn Arg Cys Cys 
        435                 440                 445             


Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys Ala His Gly 
    450                 455                 460                 


Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr Ala Cys Arg 
465                 470                 475                 480 


Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr Gly Ala Ser 
                485                 490                 495     


Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His Ser Cys Gln 
            500                 505                 510         


Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr His Glu Gln 
        515                 520                 525             


Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala Pro Gly Ile 
    530                 535                 540                 


Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly Asn Cys Gly 
545                 550                 555                 560 


Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg Asp Ala Lys 
                565                 570                 575     


Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro Val Ile Gly 
            580                 585                 590         


Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp Asp Met Pro 
    610                 615                 620                 


Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp Gly Lys Ile 
625                 630                 635                 640 


Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly Val His Glu 
                645                 650                 655     


Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn Arg Lys Asn 
            660                 665                 670         


Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp Lys Phe Gly 
        675                 680                 685             


Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala Glu Ala Arg 
    690                 695                 700                 


Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly Gln Glu Pro 
705                 710                 715                 720 


Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr Leu Ile 
                725                 730                 735 


<210>  192
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM15__Homo_sapiens__NP_001248393

<400>  192

Met Arg Leu Ala Leu Leu Trp Ala Leu Gly Leu Leu Gly Ala Gly Ser 
1               5                   10                  15      


Pro Leu Pro Ser Trp Pro Leu Pro Asn Ile Val Leu Ser Trp Gly Val 
            20                  25                  30          


Leu Gly Pro Ala Gly Gly Thr Glu Glu Gln Gln Ala Glu Ser Glu Lys 
        35                  40                  45              


Ala Pro Arg Glu Pro Leu Glu Pro Gln Val Leu Gln Asp Asp Leu Pro 
    50                  55                  60                  


Ile Ser Leu Lys Lys Val Leu Gln Thr Ser Leu Pro Glu Pro Leu Arg 
65                  70                  75                  80  


Ile Lys Leu Glu Leu Asp Gly Asp Ser His Ile Leu Glu Leu Leu Gln 
                85                  90                  95      


Asn Arg Glu Leu Val Pro Gly Arg Pro Thr Leu Val Trp Tyr Gln Pro 
            100                 105                 110         


Asp Gly Thr Arg Val Val Ser Glu Gly His Thr Leu Glu Asn Cys Cys 
        115                 120                 125             


Tyr Gln Gly Arg Val Arg Gly Tyr Ala Gly Ser Trp Val Ser Ile Cys 
    130                 135                 140                 


Thr Cys Ser Gly Leu Arg Gly Leu Val Val Leu Thr Pro Glu Arg Ser 
145                 150                 155                 160 


Tyr Thr Leu Glu Gln Gly Pro Gly Asp Leu Gln Gly Pro Pro Ile Ile 
                165                 170                 175     


Ser Arg Ile Gln Asp Leu His Leu Pro Gly His Thr Cys Ala Leu Ser 
            180                 185                 190         


Trp Arg Glu Ser Val His Thr Gln Lys Pro Pro Glu His Pro Leu Gly 
        195                 200                 205             


Gln Arg His Ile Arg Arg Arg Arg Asp Val Val Thr Glu Thr Lys Thr 
    210                 215                 220                 


Val Glu Leu Val Ile Val Ala Asp His Ser Glu Ala Gln Lys Tyr Arg 
225                 230                 235                 240 


Asp Phe Gln His Leu Leu Asn Arg Thr Leu Glu Val Ala Leu Leu Leu 
                245                 250                 255     


Asp Thr Phe Phe Arg Pro Leu Asn Val Arg Val Ala Leu Val Gly Leu 
            260                 265                 270         


Glu Ala Trp Thr Gln Arg Asp Leu Val Glu Ile Ser Pro Asn Pro Ala 
        275                 280                 285             


Val Thr Leu Glu Asn Phe Leu His Trp Arg Arg Ala His Leu Leu Pro 
    290                 295                 300                 


Arg Leu Pro His Asp Ser Ala Gln Leu Val Thr Gly Thr Ser Phe Ser 
305                 310                 315                 320 


Gly Pro Thr Val Gly Met Ala Ile Gln Asn Ser Ile Cys Ser Pro Asp 
                325                 330                 335     


Phe Ser Gly Gly Val Asn Met Asp His Ser Thr Ser Ile Leu Gly Val 
            340                 345                 350         


Ala Ser Ser Ile Ala His Glu Leu Gly His Ser Leu Gly Leu Asp His 
        355                 360                 365             


Asp Leu Pro Gly Asn Ser Cys Pro Cys Pro Gly Pro Ala Pro Ala Lys 
    370                 375                 380                 


Thr Cys Ile Met Glu Ala Ser Thr Asp Phe Leu Pro Gly Leu Asn Phe 
385                 390                 395                 400 


Ser Asn Cys Ser Arg Arg Ala Leu Glu Lys Ala Leu Leu Asp Gly Met 
                405                 410                 415     


Gly Ser Cys Leu Phe Glu Arg Leu Pro Ser Leu Pro Pro Met Ala Ala 
            420                 425                 430         


Phe Cys Gly Asn Met Phe Val Glu Pro Gly Glu Gln Cys Asp Cys Gly 
        435                 440                 445             


Phe Leu Asp Asp Cys Val Asp Pro Cys Cys Asp Ser Leu Thr Cys Gln 
    450                 455                 460                 


Leu Arg Pro Gly Ala Gln Cys Ala Ser Asp Gly Pro Cys Cys Gln Asn 
465                 470                 475                 480 


Cys Gln Leu Arg Pro Ser Gly Trp Gln Cys Arg Pro Thr Arg Gly Asp 
                485                 490                 495     


Cys Asp Leu Pro Glu Phe Cys Pro Gly Asp Ser Ser Gln Cys Pro Pro 
            500                 505                 510         


Asp Val Ser Leu Gly Asp Gly Glu Pro Cys Ala Gly Gly Gln Ala Val 
        515                 520                 525             


Cys Met His Gly Arg Cys Ala Ser Tyr Ala Gln Gln Cys Gln Ser Leu 
    530                 535                 540                 


Trp Gly Pro Gly Ala Gln Pro Ala Ala Pro Leu Cys Leu Gln Thr Ala 
545                 550                 555                 560 


Asn Thr Arg Gly Asn Ala Phe Gly Ser Cys Gly Arg Asn Pro Ser Gly 
                565                 570                 575     


Ser Tyr Val Ser Cys Thr Pro Arg Asp Ala Ile Cys Gly Gln Leu Gln 
            580                 585                 590         


Cys Gln Thr Gly Arg Thr Gln Pro Leu Leu Gly Ser Ile Arg Asp Leu 
        595                 600                 605             


Leu Trp Glu Thr Ile Asp Val Asn Gly Thr Glu Leu Asn Cys Ser Trp 
    610                 615                 620                 


Val His Leu Asp Leu Gly Ser Asp Val Ala Gln Pro Leu Leu Thr Leu 
625                 630                 635                 640 


Pro Gly Thr Ala Cys Gly Pro Gly Leu Val Cys Ile Asp His Arg Cys 
                645                 650                 655     


Gln Arg Val Asp Leu Leu Gly Ala Gln Glu Cys Arg Ser Lys Cys His 
            660                 665                 670         


Gly His Gly Val Cys Asp Ser Asn Arg His Cys Tyr Cys Glu Glu Gly 
        675                 680                 685             


Trp Ala Pro Pro Asp Cys Thr Thr Gln Leu Lys Ala Thr Ser Ser Leu 
    690                 695                 700                 


Thr Thr Gly Leu Leu Leu Ser Leu Leu Val Leu Leu Val Leu Val Met 
705                 710                 715                 720 


Leu Gly Ala Ser Tyr Trp Tyr Arg Ala Arg Leu His Gln Arg Leu Cys 
                725                 730                 735     


Gln Leu Lys Gly Pro Thr Cys Gln Tyr Arg Ala Ala Gln Ser Gly Pro 
            740                 745                 750         


Ser Glu Arg Pro Gly Pro Pro Gln Arg Ala Leu Leu Ala Arg Gly Thr 
        755                 760                 765             


Lys Ser Gln Gly Pro Ala Lys Pro Pro Pro Pro Arg Lys Pro Leu Pro 
    770                 775                 780                 


Ala Asp Pro Gln Gly Arg Cys Pro Ser Gly Asp Leu Pro Gly Pro Gly 
785                 790                 795                 800 


Ala Gly Ile Pro Pro Leu Val Val Pro Ser Arg Pro Ala Pro Pro Pro 
                805                 810                 815     


Pro Thr Val Ser Ser Leu Tyr Leu 
            820                 


<210>  193
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM17__Homo_sapiens__NP_003174

<400>  193

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
        275                 280                 285             


Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
    290                 295                 300                 


Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
305                 310                 315                 320 


Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                325                 330                 335     


Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
            340                 345                 350         


Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
        355                 360                 365             


Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
    370                 375                 380                 


Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
385                 390                 395                 400 


Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                405                 410                 415     


Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
            420                 425                 430         


Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
        435                 440                 445             


Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
    450                 455                 460                 


Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
465                 470                 475                 480 


Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                485                 490                 495     


Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
            500                 505                 510         


Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
        515                 520                 525             


Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
    530                 535                 540                 


Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                565                 570                 575     


Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
            580                 585                 590         


Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
        595                 600                 605             


Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
    610                 615                 620                 


Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
625                 630                 635                 640 


Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                645                 650                 655     


Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
            660                 665                 670         


Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
        675                 680                 685             


Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
    690                 695                 700                 


Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
705                 710                 715                 720 


Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                725                 730                 735     


Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
            740                 745                 750         


Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
        755                 760                 765             


Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
    770                 775                 780                 


Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
785                 790                 795                 800 


Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                805                 810                 815     


Val Asp Ser Lys Glu Thr Glu Cys 
            820                 


<210>  194
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM19__Homo_sapiens__NP_150377

<400>  194

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  195
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM20__Homo_sapiens__XP_005268209

<400>  195

Met Val Gln Leu His Gln Asp Thr Asp Pro Gln Ile Pro Lys Gly Gln 
1               5                   10                  15      


Pro Cys Thr Leu Asn Ser Ser Glu Gly Gly Ala Arg Pro Ala Val Pro 
            20                  25                  30          


His Thr Leu Phe Ser Ser Ala Leu Asp Arg Trp Leu His Asn Asp Ser 
        35                  40                  45              


Phe Ile Met Ala Val Gly Glu Pro Leu Val His Ile Arg Val Thr Leu 
    50                  55                  60                  


Leu Leu Leu Trp Phe Gly Met Phe Leu Ser Ile Ser Gly His Ser Gln 
65                  70                  75                  80  


Ala Arg Pro Ser Gln Tyr Phe Thr Ser Pro Glu Val Val Ile Pro Leu 
                85                  90                  95      


Lys Val Ile Ser Arg Gly Arg Gly Ala Lys Ala Pro Gly Trp Leu Ser 
            100                 105                 110         


Tyr Ser Leu Arg Phe Gly Gly Gln Arg Tyr Ile Val His Met Arg Val 
        115                 120                 125             


Asn Lys Leu Leu Phe Ala Ala His Leu Pro Val Phe Thr Tyr Thr Glu 
    130                 135                 140                 


Gln His Ala Leu Leu Gln Asp Gln Pro Phe Ile Gln Asp Asp Cys Tyr 
145                 150                 155                 160 


Tyr His Gly Tyr Val Glu Gly Val Pro Glu Ser Leu Val Ala Leu Ser 
                165                 170                 175     


Thr Cys Ser Gly Gly Phe Leu Gly Met Leu Gln Ile Asn Asp Leu Val 
            180                 185                 190         


Tyr Glu Ile Lys Pro Ile Ser Val Ser Ala Thr Phe Glu His Leu Val 
        195                 200                 205             


Tyr Lys Ile Asp Ser Asp Asp Thr Gln Phe Pro Pro Met Arg Cys Gly 
    210                 215                 220                 


Leu Thr Glu Glu Lys Ile Ala His Gln Met Glu Leu Gln Leu Ser Tyr 
225                 230                 235                 240 


Asn Phe Thr Leu Lys Gln Ser Ser Phe Val Gly Trp Trp Thr His Gln 
                245                 250                 255     


Arg Phe Val Glu Leu Val Val Val Val Asp Asn Ile Arg Tyr Leu Phe 
            260                 265                 270         


Ser Gln Ser Asn Ala Thr Thr Val Gln His Glu Val Phe Asn Val Val 
        275                 280                 285             


Asn Ile Val Asp Ser Phe Tyr His Pro Leu Glu Val Asp Val Ile Leu 
    290                 295                 300                 


Thr Gly Ile Asp Ile Trp Thr Ala Ser Asn Pro Leu Pro Thr Ser Gly 
305                 310                 315                 320 


Asp Leu Asp Asn Val Leu Glu Asp Phe Ser Ile Trp Lys Asn Tyr Asn 
                325                 330                 335     


Leu Asn Asn Arg Leu Gln His Asp Val Ala His Leu Phe Ile Lys Asp 
            340                 345                 350         


Thr Gln Gly Met Lys Leu Gly Val Ala Tyr Val Lys Gly Ile Cys Gln 
        355                 360                 365             


Asn Pro Phe Asn Thr Gly Val Asp Val Phe Glu Asp Asn Arg Leu Val 
    370                 375                 380                 


Val Phe Ala Ile Thr Leu Gly His Glu Leu Gly His Asn Leu Gly Met 
385                 390                 395                 400 


Gln His Asp Thr Gln Trp Cys Val Cys Glu Leu Gln Trp Cys Ile Met 
                405                 410                 415     


His Ala Tyr Arg Lys Val Thr Thr Lys Phe Ser Asn Cys Ser Tyr Ala 
            420                 425                 430         


Gln Tyr Trp Asp Ser Thr Ile Ser Ser Gly Leu Cys Ile Gln Pro Pro 
        435                 440                 445             


Pro Tyr Pro Gly Asn Ile Phe Arg Leu Lys Tyr Cys Gly Asn Leu Val 
    450                 455                 460                 


Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Thr Ile Arg Gln Cys Ala 
465                 470                 475                 480 


Lys Asp Pro Cys Cys Leu Leu Asn Cys Thr Leu His Pro Gly Ala Ala 
                485                 490                 495     


Cys Ala Phe Gly Ile Cys Cys Lys Asp Cys Lys Phe Leu Pro Ser Gly 
            500                 505                 510         


Thr Leu Cys Arg Gln Gln Val Gly Glu Cys Asp Leu Pro Glu Trp Cys 
        515                 520                 525             


Asn Gly Thr Ser His Gln Cys Pro Asp Asp Val Tyr Val Gln Asp Gly 
    530                 535                 540                 


Ile Ser Cys Asn Val Asn Ala Phe Cys Tyr Glu Lys Thr Cys Asn Asn 
545                 550                 555                 560 


His Asp Ile Gln Cys Lys Glu Ile Phe Gly Gln Asp Ala Arg Ser Ala 
                565                 570                 575     


Ser Gln Ser Cys Tyr Gln Glu Ile Asn Thr Gln Gly Asn Arg Phe Gly 
            580                 585                 590         


His Cys Gly Ile Val Gly Thr Thr Tyr Val Lys Cys Trp Thr Pro Asp 
        595                 600                 605             


Ile Met Cys Gly Arg Val Gln Cys Glu Asn Val Gly Val Ile Pro Asn 
    610                 615                 620                 


Leu Ile Glu His Ser Thr Val Gln Gln Phe His Leu Asn Asp Thr Thr 
625                 630                 635                 640 


Cys Trp Gly Thr Asp Tyr His Leu Gly Met Ala Ile Pro Asp Ile Gly 
                645                 650                 655     


Glu Val Lys Asp Gly Thr Val Cys Gly Pro Glu Lys Ile Cys Ile Arg 
            660                 665                 670         


Lys Lys Cys Ala Ser Met Val His Leu Ser Gln Ala Cys Gln Pro Lys 
        675                 680                 685             


Thr Cys Asn Met Arg Gly Ile Cys Asn Asn Lys Gln His Cys His Cys 
    690                 695                 700                 


Asn His Glu Trp Ala Pro Pro Tyr Cys Lys Asp Lys Gly Tyr Gly Gly 
705                 710                 715                 720 


Ser Ala Asp Ser Gly Pro Pro Pro Lys Asn Asn Met Glu Gly Leu Asn 
                725                 730                 735     


Val Met Gly Lys Leu Arg Tyr Leu Ser Leu Leu Cys Leu Leu Pro Leu 
            740                 745                 750         


Val Ala Phe Leu Leu Phe Cys Leu His Val Leu Phe Lys Lys Arg Thr 
        755                 760                 765             


Lys Ser Lys Glu Asp Glu Glu Gly 
    770                 775     


<210>  196
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM21__Homo_sapiens__NP_003804

<400>  196

Met Ala Val Asp Gly Thr Leu Val Tyr Ile Arg Val Thr Leu Leu Leu 
1               5                   10                  15      


Leu Trp Leu Gly Val Phe Leu Ser Ile Ser Gly Tyr Cys Gln Ala Gly 
            20                  25                  30          


Pro Ser Gln His Phe Thr Ser Pro Glu Val Val Ile Pro Leu Lys Val 
        35                  40                  45              


Ile Ser Arg Gly Arg Ser Ala Lys Ala Pro Gly Trp Leu Ser Tyr Ser 
    50                  55                  60                  


Leu Arg Phe Gly Gly Gln Lys His Val Val His Met Arg Val Lys Lys 
65                  70                  75                  80  


Leu Leu Val Ser Arg His Leu Pro Val Phe Thr Tyr Thr Asp Asp Arg 
                85                  90                  95      


Ala Leu Leu Glu Asp Gln Leu Phe Ile Pro Asp Asp Cys Tyr Tyr His 
            100                 105                 110         


Gly Tyr Val Glu Ala Ala Pro Glu Ser Leu Val Val Phe Ser Ala Cys 
        115                 120                 125             


Phe Gly Gly Phe Arg Gly Val Leu Lys Ile Ser Gly Leu Thr Tyr Glu 
    130                 135                 140                 


Ile Glu Pro Ile Arg His Ser Ala Thr Phe Glu His Leu Val Tyr Lys 
145                 150                 155                 160 


Ile Asn Ser Asn Glu Thr Gln Phe Pro Ala Met Arg Cys Gly Leu Thr 
                165                 170                 175     


Glu Lys Glu Val Ala Arg Gln Gln Leu Glu Phe Glu Glu Ala Glu Asn 
            180                 185                 190         


Ser Ala Leu Glu Pro Lys Ser Ala Gly Asp Trp Trp Thr His Ala Trp 
        195                 200                 205             


Phe Leu Glu Leu Val Val Val Val Asn His Asp Phe Phe Ile Tyr Ser 
    210                 215                 220                 


Gln Ser Asn Ile Ser Lys Val Gln Glu Asp Val Phe Leu Val Val Asn 
225                 230                 235                 240 


Ile Val Asp Ser Met Tyr Lys Gln Leu Gly Thr Tyr Ile Ile Leu Ile 
                245                 250                 255     


Gly Ile Glu Ile Trp Asn Gln Gly Asn Val Phe Pro Met Thr Ser Ile 
            260                 265                 270         


Glu Gln Val Leu Asn Asp Phe Ser Gln Trp Lys Gln Ile Ser Leu Ser 
        275                 280                 285             


Gln Leu Gln His Asp Ala Ala His Met Phe Ile Lys Asn Ser Leu Ile 
    290                 295                 300                 


Ser Ile Leu Gly Leu Ala Tyr Val Ala Gly Ile Cys Arg Pro Pro Ile 
305                 310                 315                 320 


Asp Cys Gly Val Asp Asn Phe Gln Gly Asp Thr Trp Ser Leu Phe Ala 
                325                 330                 335     


Asn Thr Val Ala His Glu Leu Gly His Thr Leu Gly Met Gln His Asp 
            340                 345                 350         


Glu Glu Phe Cys Phe Cys Gly Glu Arg Gly Cys Ile Met Asn Thr Phe 
        355                 360                 365             


Arg Val Pro Ala Glu Lys Phe Thr Asn Cys Ser Tyr Ala Asp Phe Met 
    370                 375                 380                 


Lys Thr Thr Leu Asn Gln Gly Ser Cys Leu His Asn Pro Pro Arg Leu 
385                 390                 395                 400 


Gly Glu Ile Phe Met Leu Lys Arg Cys Gly Asn Gly Val Val Glu Arg 
                405                 410                 415     


Glu Glu Gln Cys Asp Cys Gly Ser Val Gln Gln Cys Glu Gln Asp Ala 
            420                 425                 430         


Cys Cys Leu Leu Asn Cys Thr Leu Arg Pro Gly Ala Ala Cys Ala Phe 
        435                 440                 445             


Gly Leu Cys Cys Lys Asp Cys Lys Phe Met Pro Ser Gly Glu Leu Cys 
    450                 455                 460                 


Arg Gln Glu Val Asn Glu Cys Asp Leu Pro Glu Trp Cys Asn Gly Thr 
465                 470                 475                 480 


Ser His Gln Cys Pro Glu Asp Arg Tyr Val Gln Asp Gly Ile Pro Cys 
                485                 490                 495     


Ser Asp Ser Ala Tyr Cys Tyr Gln Lys Arg Cys Asn Asn His Asp Gln 
            500                 505                 510         


His Cys Arg Glu Ile Phe Gly Lys Asp Ala Lys Ser Ala Ser Gln Asn 
        515                 520                 525             


Cys Tyr Lys Glu Ile Asn Ser Gln Gly Asn Arg Phe Gly His Cys Gly 
    530                 535                 540                 


Ile Asn Gly Thr Thr Tyr Leu Lys Cys His Ile Ser Asp Val Phe Cys 
545                 550                 555                 560 


Gly Arg Val Gln Cys Glu Asn Val Arg Asp Ile Pro Leu Leu Gln Asp 
                565                 570                 575     


His Phe Thr Leu Gln His Thr His Ile Asn Gly Val Thr Cys Trp Gly 
            580                 585                 590         


Ile Asp Tyr His Leu Arg Met Asn Ile Ser Asp Ile Gly Glu Val Lys 
        595                 600                 605             


Asp Gly Thr Val Cys Gly Pro Gly Lys Ile Cys Ile His Lys Lys Cys 
    610                 615                 620                 


Val Ser Leu Ser Val Leu Ser His Val Cys Leu Pro Glu Thr Cys Asn 
625                 630                 635                 640 


Met Lys Gly Ile Cys Asn Asn Lys His His Cys His Cys Gly Tyr Gly 
                645                 650                 655     


Trp Ser Pro Pro Tyr Cys Gln His Arg Gly Tyr Gly Gly Ser Ile Asp 
            660                 665                 670         


Ser Gly Pro Ala Ser Ala Lys Arg Gly Val Phe Leu Pro Leu Ile Val 
        675                 680                 685             


Ile Pro Ser Leu Ser Val Leu Thr Phe Leu Phe Thr Val Gly Leu Leu 
    690                 695                 700                 


Met Tyr Leu Arg Gln Cys Ser Gly Pro Lys Glu Thr Lys Ala His Ser 
705                 710                 715                 720 


Ser Gly 
        


<210>  197
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM22__Homo_sapiens__NP_057435

<400>  197

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765             


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780                 


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800 


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815     


Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala Lys Ser Pro Ser 
            820                 825                 830         


Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met 
        835                 840                 845             


Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg 
    850                 855                 860                 


Leu Trp Glu Thr Ser Ile 
865                 870 


<210>  198
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM23__Homo_sapiens__NP_003803

<400>  198

Met Lys Pro Pro Gly Ser Ser Ser Arg Gln Pro Pro Leu Ala Gly Cys 
1               5                   10                  15      


Ser Leu Ala Gly Ala Ser Cys Gly Pro Gln Arg Gly Pro Ala Gly Ser 
            20                  25                  30          


Val Pro Ala Ser Ala Pro Ala Arg Thr Pro Pro Cys Arg Leu Leu Leu 
        35                  40                  45              


Val Leu Leu Leu Leu Pro Pro Leu Ala Ala Ser Ser Arg Pro Arg Ala 
    50                  55                  60                  


Trp Gly Ala Ala Ala Pro Ser Ala Pro His Trp Asn Glu Thr Ala Glu 
65                  70                  75                  80  


Lys Asn Leu Gly Val Leu Ala Asp Glu Asp Asn Thr Leu Gln Gln Asn 
                85                  90                  95      


Ser Ser Ser Asn Ile Ser Tyr Ser Asn Ala Met Gln Lys Glu Ile Thr 
            100                 105                 110         


Leu Pro Ser Arg Leu Ile Tyr Tyr Ile Asn Gln Asp Ser Glu Ser Pro 
        115                 120                 125             


Tyr His Val Leu Asp Thr Lys Ala Arg His Gln Gln Lys His Asn Lys 
    130                 135                 140                 


Ala Val His Leu Ala Gln Ala Ser Phe Gln Ile Glu Ala Phe Gly Ser 
145                 150                 155                 160 


Lys Phe Ile Leu Asp Leu Ile Leu Asn Asn Gly Leu Leu Ser Ser Asp 
                165                 170                 175     


Tyr Val Glu Ile His Tyr Glu Asn Gly Lys Pro Gln Tyr Ser Lys Gly 
            180                 185                 190         


Gly Glu His Cys Tyr Tyr His Gly Ser Ile Arg Gly Val Lys Asp Ser 
        195                 200                 205             


Lys Val Ala Leu Ser Thr Cys Asn Gly Leu His Gly Met Phe Glu Asp 
    210                 215                 220                 


Asp Thr Phe Val Tyr Met Ile Glu Pro Leu Glu Leu Val His Asp Glu 
225                 230                 235                 240 


Lys Ser Thr Gly Arg Pro His Ile Ile Gln Lys Thr Leu Ala Gly Gln 
                245                 250                 255     


Tyr Ser Lys Gln Met Lys Asn Leu Thr Met Glu Arg Gly Asp Gln Trp 
            260                 265                 270         


Pro Phe Leu Ser Glu Leu Gln Trp Leu Lys Arg Arg Lys Arg Ala Val 
        275                 280                 285             


Asn Pro Ser Arg Gly Ile Phe Glu Glu Met Lys Tyr Leu Glu Leu Met 
    290                 295                 300                 


Ile Val Asn Asp His Lys Thr Tyr Lys Lys His Arg Ser Ser His Ala 
305                 310                 315                 320 


His Thr Asn Asn Phe Ala Lys Ser Val Val Asn Leu Val Asp Ser Ile 
                325                 330                 335     


Tyr Lys Glu Gln Leu Asn Thr Arg Val Val Leu Val Ala Val Glu Thr 
            340                 345                 350         


Trp Thr Glu Lys Asp Gln Ile Asp Ile Thr Thr Asn Pro Val Gln Met 
        355                 360                 365             


Leu His Glu Phe Ser Lys Tyr Arg Gln Arg Ile Lys Gln His Ala Asp 
    370                 375                 380                 


Ala Val His Leu Ile Ser Arg Val Thr Phe His Tyr Lys Arg Ser Ser 
385                 390                 395                 400 


Leu Ser Tyr Phe Gly Gly Val Cys Ser Arg Thr Arg Gly Val Gly Val 
                405                 410                 415     


Asn Glu Tyr Gly Leu Pro Met Ala Val Ala Gln Val Leu Ser Gln Ser 
            420                 425                 430         


Leu Ala Gln Asn Leu Gly Ile Gln Trp Glu Pro Ser Ser Arg Lys Pro 
        435                 440                 445             


Lys Cys Asp Cys Thr Glu Ser Trp Gly Gly Cys Ile Met Glu Glu Thr 
    450                 455                 460                 


Gly Val Ser His Ser Arg Lys Phe Ser Lys Cys Ser Ile Leu Glu Tyr 
465                 470                 475                 480 


Arg Asp Phe Leu Gln Arg Gly Gly Gly Ala Cys Leu Phe Asn Arg Pro 
                485                 490                 495     


Thr Lys Leu Phe Glu Pro Thr Glu Cys Gly Asn Gly Tyr Val Glu Ala 
            500                 505                 510         


Gly Glu Glu Cys Asp Cys Gly Phe His Val Glu Cys Tyr Gly Leu Cys 
        515                 520                 525             


Cys Lys Lys Cys Ser Leu Ser Asn Gly Ala His Cys Ser Asp Gly Pro 
    530                 535                 540                 


Cys Cys Asn Asn Thr Ser Cys Leu Phe Gln Pro Arg Gly Tyr Glu Cys 
545                 550                 555                 560 


Arg Asp Ala Val Asn Glu Cys Asp Ile Thr Glu Tyr Cys Thr Gly Asp 
                565                 570                 575     


Ser Gly Gln Cys Pro Pro Asn Leu His Lys Gln Asp Gly Tyr Ala Cys 
            580                 585                 590         


Asn Gln Asn Gln Gly Arg Cys Tyr Asn Gly Glu Cys Lys Thr Arg Asp 
        595                 600                 605             


Asn Gln Cys Gln Tyr Ile Trp Gly Thr Lys Ala Ala Gly Ser Asp Lys 
    610                 615                 620                 


Phe Cys Tyr Glu Lys Leu Asn Thr Glu Gly Thr Glu Lys Gly Asn Cys 
625                 630                 635                 640 


Gly Lys Asp Gly Asp Arg Trp Ile Gln Cys Ser Lys His Asp Val Phe 
                645                 650                 655     


Cys Gly Phe Leu Leu Cys Thr Asn Leu Thr Arg Ala Pro Arg Ile Gly 
            660                 665                 670         


Gln Leu Gln Gly Glu Ile Ile Pro Thr Ser Phe Tyr His Gln Gly Arg 
        675                 680                 685             


Val Ile Asp Cys Ser Gly Ala His Val Val Leu Asp Asp Asp Thr Asp 
    690                 695                 700                 


Val Gly Tyr Val Glu Asp Gly Thr Pro Cys Gly Pro Ser Met Met Cys 
705                 710                 715                 720 


Leu Asp Arg Lys Cys Leu Gln Ile Gln Ala Leu Asn Met Ser Ser Cys 
                725                 730                 735     


Pro Leu Asp Ser Lys Gly Lys Val Cys Ser Gly His Gly Val Cys Ser 
            740                 745                 750         


Asn Glu Ala Thr Cys Ile Cys Asp Phe Thr Trp Ala Gly Thr Asp Cys 
        755                 760                 765             


Ser Ile Arg Asp Pro Val Arg Asn Leu His Pro Pro Lys Asp Glu Gly 
    770                 775                 780                 


Pro Lys Gly Pro Ser Ala Thr Asn Leu Ile Ile Gly Ser Ile Ala Gly 
785                 790                 795                 800 


Ala Ile Leu Val Ala Ala Ile Val Leu Gly Gly Thr Gly Trp Gly Phe 
                805                 810                 815     


Lys Asn Val Lys Lys Arg Arg Phe Asp Pro Thr Gln Gln Gly Pro Ile 
            820                 825                 830         


<210>  199
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28__Homo_sapiens__NP_055080

<400>  199

Met Leu Gln Gly Leu Leu Pro Val Ser Leu Leu Leu Ser Val Ala Val 
1               5                   10                  15      


Ser Ala Ile Lys Glu Leu Pro Gly Val Lys Lys Tyr Glu Val Val Tyr 
            20                  25                  30          


Pro Ile Arg Leu His Pro Leu His Lys Arg Glu Ala Lys Glu Pro Glu 
        35                  40                  45              


Gln Gln Glu Gln Phe Glu Thr Glu Leu Lys Tyr Lys Met Thr Ile Asn 
    50                  55                  60                  


Gly Lys Ile Ala Val Leu Tyr Leu Lys Lys Asn Lys Asn Leu Leu Ala 
65                  70                  75                  80  


Pro Gly Tyr Thr Glu Thr Tyr Tyr Asn Ser Thr Gly Lys Glu Ile Thr 
                85                  90                  95      


Thr Ser Pro Gln Ile Met Asp Asp Cys Tyr Tyr Gln Gly His Ile Leu 
            100                 105                 110         


Asn Glu Lys Val Ser Asp Ala Ser Ile Ser Thr Cys Arg Gly Leu Arg 
        115                 120                 125             


Gly Tyr Phe Ser Gln Gly Asp Gln Arg Tyr Phe Ile Glu Pro Leu Ser 
    130                 135                 140                 


Pro Ile His Arg Asp Gly Gln Glu His Ala Leu Phe Lys Tyr Asn Pro 
145                 150                 155                 160 


Asp Glu Lys Asn Tyr Asp Ser Thr Cys Gly Met Asp Gly Val Leu Trp 
                165                 170                 175     


Ala His Asp Leu Gln Gln Asn Ile Ala Leu Pro Ala Thr Lys Leu Val 
            180                 185                 190         


Lys Leu Lys Asp Arg Lys Val Gln Glu His Glu Lys Tyr Ile Glu Tyr 
        195                 200                 205             


Tyr Leu Val Leu Asp Asn Gly Glu Phe Lys Arg Tyr Asn Glu Asn Gln 
    210                 215                 220                 


Asp Glu Ile Arg Lys Arg Val Phe Glu Met Ala Asn Tyr Val Asn Met 
225                 230                 235                 240 


Leu Tyr Lys Lys Leu Asn Thr His Val Ala Leu Val Gly Met Glu Ile 
                245                 250                 255     


Trp Thr Asp Lys Asp Lys Ile Lys Ile Thr Pro Asn Ala Ser Phe Thr 
            260                 265                 270         


Leu Glu Asn Phe Ser Lys Trp Arg Gly Ser Val Leu Ser Arg Arg Lys 
        275                 280                 285             


Arg His Asp Ile Ala Gln Leu Ile Thr Ala Thr Glu Leu Ala Gly Thr 
    290                 295                 300                 


Thr Val Gly Leu Ala Phe Met Ser Thr Met Cys Ser Pro Tyr Ser Val 
305                 310                 315                 320 


Gly Val Val Gln Asp His Ser Asp Asn Leu Leu Arg Val Ala Gly Thr 
                325                 330                 335     


Met Ala His Glu Met Gly His Asn Phe Gly Met Phe His Asp Asp Tyr 
            340                 345                 350         


Ser Cys Lys Cys Pro Ser Thr Ile Cys Val Met Asp Lys Ala Leu Ser 
        355                 360                 365             


Phe Tyr Ile Pro Thr Asp Phe Ser Ser Cys Ser Arg Leu Ser Tyr Asp 
    370                 375                 380                 


Lys Phe Phe Glu Asp Lys Leu Ser Asn Cys Leu Phe Asn Ala Pro Leu 
385                 390                 395                 400 


Pro Thr Asp Ile Ile Ser Thr Pro Ile Cys Gly Asn Gln Leu Val Glu 
                405                 410                 415     


Met Gly Glu Asp Cys Asp Cys Gly Thr Ser Glu Glu Cys Thr Asn Ile 
            420                 425                 430         


Cys Cys Asp Ala Lys Thr Cys Lys Ile Lys Ala Thr Phe Gln Cys Ala 
        435                 440                 445             


Leu Gly Glu Cys Cys Glu Lys Cys Gln Phe Lys Lys Ala Gly Met Val 
    450                 455                 460                 


Cys Arg Pro Ala Lys Asp Glu Cys Asp Leu Pro Glu Met Cys Asn Gly 
465                 470                 475                 480 


Lys Ser Gly Asn Cys Pro Asp Asp Arg Phe Gln Val Asn Gly Phe Pro 
                485                 490                 495     


Cys His His Gly Lys Gly His Cys Leu Met Gly Thr Cys Pro Thr Leu 
            500                 505                 510         


Gln Glu Gln Cys Thr Glu Leu Trp Gly Pro Gly Thr Glu Val Ala Asp 
        515                 520                 525             


Lys Ser Cys Tyr Asn Arg Asn Glu Gly Gly Ser Lys Tyr Gly Tyr Cys 
    530                 535                 540                 


Arg Arg Val Asp Asp Thr Leu Ile Pro Cys Lys Ala Asn Asp Thr Met 
545                 550                 555                 560 


Cys Gly Lys Leu Phe Cys Gln Gly Gly Ser Asp Asn Leu Pro Trp Lys 
                565                 570                 575     


Gly Arg Ile Val Thr Phe Leu Thr Cys Lys Thr Phe Asp Pro Glu Asp 
            580                 585                 590         


Thr Ser Gln Glu Ile Gly Met Val Ala Asn Gly Thr Lys Cys Gly Asp 
        595                 600                 605             


Asn Lys Val Cys Ile Asn Ala Glu Cys Val Asp Ile Glu Lys Ala Tyr 
    610                 615                 620                 


Lys Ser Thr Asn Cys Ser Ser Lys Cys Lys Gly His Ala Val Cys Asp 
625                 630                 635                 640 


His Glu Leu Gln Cys Gln Cys Glu Glu Gly Trp Ile Pro Pro Asp Cys 
                645                 650                 655     


Asp Asp Ser Ser Val Val Phe His Phe Ser Ile Val Val Gly Val Leu 
            660                 665                 670         


Phe Pro Met Ala Val Ile Phe Val Val Val Ala Met Val Ile Arg His 
        675                 680                 685             


Gln Ser Ser Arg Glu Lys Gln Lys Lys Asp Gln Arg Pro Leu Ser Thr 
    690                 695                 700                 


Thr Gly Thr Arg Pro His Lys Gln Lys Arg Lys Pro Gln Met Val Lys 
705                 710                 715                 720 


Ala Val Gln Pro Gln Glu Met Ser Gln Met Lys Pro His Val Tyr Asp 
                725                 730                 735     


Leu Pro Val Glu Gly Asn Glu Pro Pro Ala Ser Phe His Lys Asp Thr 
            740                 745                 750         


Asn Ala Leu Pro Pro Thr Val Phe Lys Asp Asn Pro Val Ser Thr Pro 
        755                 760                 765             


Lys Asp Ser Asn Pro Lys Ala 
    770                 775 


<210>  200
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM29__Homo_sapiens__NP_001265056

<400>  200

Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys 
1               5                   10                  15      


Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp 
            20                  25                  30          


Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro 
        35                  40                  45              


Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile 
    50                  55                  60                  


Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val 
65                  70                  75                  80  


Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val 
                85                  90                  95      


Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser 
            100                 105                 110         


Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln 
        115                 120                 125             


Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr 
    130                 135                 140                 


Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser 
145                 150                 155                 160 


Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu 
                165                 170                 175     


Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly 
            180                 185                 190         


Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn 
        195                 200                 205             


Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp 
    210                 215                 220                 


Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly 
225                 230                 235                 240 


Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu 
                245                 250                 255     


Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp 
            260                 265                 270         


Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu 
        275                 280                 285             


Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg 
    290                 295                 300                 


Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn 
305                 310                 315                 320 


Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His 
                325                 330                 335     


Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro 
            340                 345                 350         


Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn 
        355                 360                 365             


Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys 
    370                 375                 380                 


Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys 
385                 390                 395                 400 


Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu 
                405                 410                 415     


Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr 
            420                 425                 430         


Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe 
        435                 440                 445             


Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu 
    450                 455                 460                 


Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr 
465                 470                 475                 480 


Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys 
                485                 490                 495     


Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly 
            500                 505                 510         


Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly 
        515                 520                 525             


Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys 
    530                 535                 540                 


Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr 
545                 550                 555                 560 


Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe 
                565                 570                 575     


Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly 
            580                 585                 590         


Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His 
        595                 600                 605             


Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn 
    610                 615                 620                 


Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His 
625                 630                 635                 640 


His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys 
                645                 650                 655     


Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys 
            660                 665                 670         


Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe 
        675                 680                 685             


Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile 
    690                 695                 700                 


Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys 
705                 710                 715                 720 


Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val 
                725                 730                 735     


Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro 
            740                 745                 750         


Gln Val Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser 
        755                 760                 765             


Gln Pro Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser 
    770                 775                 780                 


Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr 
785                 790                 795                 800 


Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro 
                805                 810                 815     


Val Thr Pro Ser 
            820 


<210>  201
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM2__Homo_sapiens__NP_001265042

<400>  201

Met Trp Arg Val Leu Phe Leu Leu Ser Gly Leu Gly Gly Leu Arg Met 
1               5                   10                  15      


Asp Ser Asn Phe Asp Ser Leu Pro Val Gln Ile Thr Val Pro Glu Lys 
            20                  25                  30          


Ile Arg Ser Ile Ile Lys Glu Gly Ile Glu Ser Gln Ala Ser Tyr Lys 
        35                  40                  45              


Ile Val Ile Glu Gly Lys Pro Tyr Thr Val Asn Leu Met Gln Lys Asn 
    50                  55                  60                  


Phe Leu Pro His Asn Phe Arg Val Tyr Ser Tyr Ser Gly Thr Gly Ile 
65                  70                  75                  80  


Met Lys Pro Leu Asp Gln Asp Phe Gln Asn Phe Cys His Tyr Gln Gly 
                85                  90                  95      


Tyr Ile Glu Gly Tyr Pro Lys Ser Val Val Met Val Ser Thr Cys Thr 
            100                 105                 110         


Gly Leu Arg Gly Val Leu Gln Phe Glu Asn Val Ser Tyr Gly Ile Glu 
        115                 120                 125             


Pro Leu Glu Ser Ser Val Gly Phe Glu His Val Ile Tyr Gln Val Lys 
    130                 135                 140                 


His Lys Lys Ala Asp Val Ser Leu Tyr Asn Glu Lys Asp Ile Glu Ser 
145                 150                 155                 160 


Arg Asp Leu Ser Phe Lys Leu Gln Ser Val Glu Tyr Asn His Met Gly 
                165                 170                 175     


Ser Asp Thr Thr Val Val Ala Gln Lys Val Phe Gln Leu Ile Gly Leu 
            180                 185                 190         


Thr Asn Ala Ile Phe Val Ser Phe Asn Ile Thr Ile Ile Leu Ser Ser 
        195                 200                 205             


Leu Glu Leu Trp Ile Asp Glu Asn Lys Ile Ala Thr Thr Gly Glu Ala 
    210                 215                 220                 


Asn Glu Leu Leu His Thr Phe Leu Arg Trp Lys Thr Ser Tyr Leu Val 
225                 230                 235                 240 


Leu Arg Pro His Asp Val Ala Phe Leu Leu Val Tyr Arg Glu Lys Ser 
                245                 250                 255     


Asn Tyr Val Gly Ala Thr Phe Gln Gly Lys Met Cys Asp Ala Asn Tyr 
            260                 265                 270         


Ala Gly Gly Val Val Leu His Pro Arg Thr Ile Ser Leu Glu Ser Leu 
        275                 280                 285             


Ala Val Ile Leu Ala Gln Leu Leu Ser Leu Ser Met Gly Ile Thr Tyr 
    290                 295                 300                 


Asp Asp Ile Asn Lys Cys Gln Cys Ser Gly Ala Val Cys Ile Met Asn 
305                 310                 315                 320 


Pro Glu Ala Ile His Phe Ser Gly Val Lys Ile Phe Ser Asn Cys Ser 
                325                 330                 335     


Phe Glu Asp Phe Ala His Phe Ile Ser Lys Gln Lys Ser Gln Cys Leu 
            340                 345                 350         


His Asn Gln Pro Arg Leu Asp Pro Phe Phe Lys Gln Gln Ala Val Cys 
        355                 360                 365             


Gly Asn Ala Lys Leu Glu Ala Gly Glu Glu Cys Asp Cys Gly Thr Glu 
    370                 375                 380                 


Gln Asp Cys Ala Leu Ile Gly Glu Thr Cys Cys Asp Ile Ala Thr Cys 
385                 390                 395                 400 


Arg Phe Lys Ala Gly Ser Asn Cys Ala Glu Gly Pro Cys Cys Glu Asn 
                405                 410                 415     


Cys Leu Phe Met Ser Lys Glu Arg Met Cys Arg Pro Ser Phe Glu Glu 
            420                 425                 430         


Cys Asp Leu Pro Glu Tyr Cys Asn Gly Ser Ser Ala Ser Cys Pro Glu 
        435                 440                 445             


Asn His Tyr Val Gln Thr Gly His Pro Cys Gly Leu Asn Gln Trp Ile 
    450                 455                 460                 


Cys Ile Asp Gly Val Cys Met Ser Gly Asp Lys Gln Cys Thr Asp Thr 
465                 470                 475                 480 


Phe Gly Lys Glu Val Glu Phe Gly Pro Ser Glu Cys Tyr Ser His Leu 
                485                 490                 495     


Asn Ser Lys Thr Asp Val Ser Gly Asn Cys Gly Ile Ser Asp Ser Gly 
            500                 505                 510         


Tyr Thr Gln Cys Glu Ala Asp Asn Leu Gln Cys Gly Lys Leu Ile Cys 
        515                 520                 525             


Lys Tyr Val Gly Lys Phe Leu Leu Gln Ile Pro Arg Ala Thr Ile Ile 
    530                 535                 540                 


Tyr Ala Asn Ile Ser Gly His Leu Cys Ile Ala Val Glu Phe Ala Ser 
545                 550                 555                 560 


Asp His Ala Asp Ser Gln Lys Met Trp Ile Lys Asp Gly Thr Ser Cys 
                565                 570                 575     


Gly Ser Asn Lys Val Cys Arg Asn Gln Arg Cys Val Ser Ser Ser Tyr 
            580                 585                 590         


Leu Gly Tyr Asp Cys Thr Thr Asp Lys Cys Asn Asp Arg Gly Val Cys 
        595                 600                 605             


Asn Asn Lys Lys His Cys His Cys Ser Ala Ser Tyr Leu Pro Pro Asp 
    610                 615                 620                 


Cys Ser Val Gln Ser Asp Leu Trp Pro Gly Gly Ser Ile Asp Ser Gly 
625                 630                 635                 640 


Asn Phe Pro Pro Val Ala Ile Pro Ala Arg Leu Pro Glu Arg Arg Tyr 
                645                 650                 655     


Ile Glu Asn Ile Tyr His Ser Lys Pro Met Arg Trp Pro Phe Phe Leu 
            660                 665                 670         


Phe Ile Pro Phe Phe Ile Ile Phe Cys Val Leu Ile Ala Ile Met Val 
        675                 680                 685             


Lys Val Asn Phe Gln Arg Lys Lys Trp Arg Thr Glu Asp Tyr Ser Ser 
    690                 695                 700                 


Asp Glu Gln Pro Glu Ser Glu Ser Glu Pro Lys Gly 
705                 710                 715     


<210>  202
<211>  812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM33__Homo_sapiens__NP_001269376

<400>  202

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg 
625                 630                 635                 640 


Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala 
                645                 650                 655     


Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala 
            660                 665                 670         


Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser 
        675                 680                 685             


Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu 
    690                 695                 700                 


Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu 
705                 710                 715                 720 


Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser 
                725                 730                 735     


Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro 
            740                 745                 750         


His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro 
        755                 760                 765             


Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu 
    770                 775                 780                 


Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro 
785                 790                 795                 800 


Gln Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
                805                 810         


<210>  203
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM7__Homo_sapiens__NP_003808

<400>  203

Met Leu Pro Gly Cys Ile Phe Leu Met Ile Leu Leu Ile Pro Gln Val 
1               5                   10                  15      


Lys Glu Lys Phe Ile Leu Gly Val Glu Gly Gln Gln Leu Val Arg Pro 
            20                  25                  30          


Lys Lys Leu Pro Leu Ile Gln Lys Arg Asp Thr Gly His Thr His Asp 
        35                  40                  45              


Asp Asp Ile Leu Lys Thr Tyr Glu Glu Glu Leu Leu Tyr Glu Ile Lys 
    50                  55                  60                  


Leu Asn Arg Lys Thr Leu Val Leu His Leu Leu Arg Ser Arg Glu Phe 
65                  70                  75                  80  


Leu Gly Ser Asn Tyr Ser Glu Thr Phe Tyr Ser Met Lys Gly Glu Ala 
                85                  90                  95      


Phe Thr Arg His Pro Gln Ile Met Asp His Cys Phe Tyr Gln Gly Ser 
            100                 105                 110         


Ile Val His Glu Tyr Asp Ser Ala Ala Ser Ile Ser Thr Cys Asn Gly 
        115                 120                 125             


Leu Arg Gly Phe Phe Arg Ile Asn Asp Gln Arg Tyr Leu Ile Glu Pro 
    130                 135                 140                 


Val Lys Tyr Ser Asp Glu Gly Glu His Leu Val Phe Lys Tyr Asn Leu 
145                 150                 155                 160 


Arg Val Pro Tyr Gly Ala Asn Tyr Ser Cys Thr Glu Leu Asn Phe Thr 
                165                 170                 175     


Arg Lys Thr Val Pro Gly Asp Asn Glu Ser Glu Glu Asp Ser Lys Ile 
            180                 185                 190         


Lys Gly Ile His Asp Glu Lys Tyr Val Glu Leu Phe Ile Val Ala Asp 
        195                 200                 205             


Asp Thr Val Tyr Arg Arg Asn Gly His Pro His Asn Lys Leu Arg Asn 
    210                 215                 220                 


Arg Ile Trp Gly Met Val Asn Phe Val Asn Met Ile Tyr Lys Thr Leu 
225                 230                 235                 240 


Asn Ile His Val Thr Leu Val Gly Ile Glu Ile Trp Thr His Glu Asp 
                245                 250                 255     


Lys Ile Glu Leu Tyr Ser Asn Ile Glu Thr Thr Leu Leu Arg Phe Ser 
            260                 265                 270         


Phe Trp Gln Glu Lys Ile Leu Lys Thr Arg Lys Asp Phe Asp His Val 
        275                 280                 285             


Val Leu Leu Ser Gly Lys Trp Leu Tyr Ser His Val Gln Gly Ile Ser 
    290                 295                 300                 


Tyr Pro Gly Gly Met Cys Leu Pro Tyr Tyr Ser Thr Ser Ile Ile Lys 
305                 310                 315                 320 


Asp Leu Leu Pro Asp Thr Asn Ile Ile Ala Asn Arg Met Ala His Gln 
                325                 330                 335     


Leu Gly His Asn Leu Gly Met Gln His Asp Glu Phe Pro Cys Thr Cys 
            340                 345                 350         


Pro Ser Gly Lys Cys Val Met Asp Ser Asp Gly Ser Ile Pro Ala Leu 
        355                 360                 365             


Lys Phe Ser Lys Cys Ser Gln Asn Gln Tyr His Gln Tyr Leu Lys Asp 
    370                 375                 380                 


Tyr Lys Pro Thr Cys Met Leu Asn Ile Pro Phe Pro Tyr Asn Phe His 
385                 390                 395                 400 


Asp Phe Gln Phe Cys Gly Asn Lys Lys Leu Asp Glu Gly Glu Glu Cys 
                405                 410                 415     


Asp Cys Gly Pro Ala Gln Glu Cys Thr Asn Pro Cys Cys Asp Ala His 
            420                 425                 430         


Thr Cys Val Leu Lys Pro Gly Phe Thr Cys Ala Glu Gly Glu Cys Cys 
        435                 440                 445             


Glu Ser Cys Gln Ile Lys Lys Ala Gly Ser Ile Cys Arg Pro Ala Lys 
    450                 455                 460                 


Asp Glu Cys Asp Phe Pro Glu Met Cys Thr Gly His Ser Pro Ala Cys 
465                 470                 475                 480 


Pro Lys Asp Gln Phe Arg Val Asn Gly Phe Pro Cys Lys Asn Ser Glu 
                485                 490                 495     


Gly Tyr Cys Phe Met Gly Lys Cys Pro Thr Arg Glu Asp Gln Cys Ser 
            500                 505                 510         


Glu Leu Phe Asp Asp Glu Ala Ile Glu Ser His Asp Ile Cys Tyr Lys 
        515                 520                 525             


Met Asn Thr Lys Gly Asn Lys Phe Gly Tyr Cys Lys Asn Lys Glu Asn 
    530                 535                 540                 


Arg Phe Leu Pro Cys Glu Glu Lys Asp Val Arg Cys Gly Lys Ile Tyr 
545                 550                 555                 560 


Cys Thr Gly Gly Glu Leu Ser Ser Leu Leu Gly Glu Asp Lys Thr Tyr 
                565                 570                 575     


His Leu Lys Asp Pro Gln Lys Asn Ala Thr Val Lys Cys Lys Thr Ile 
            580                 585                 590         


Phe Leu Tyr His Asp Ser Thr Asp Ile Gly Leu Val Ala Ser Gly Thr 
        595                 600                 605             


Lys Cys Gly Glu Gly Met Val Cys Asn Asn Gly Glu Cys Leu Asn Met 
    610                 615                 620                 


Glu Lys Val Tyr Ile Ser Thr Asn Cys Pro Ser Gln Cys Asn Glu Asn 
625                 630                 635                 640 


Pro Val Asp Gly His Gly Leu Gln Cys His Cys Glu Glu Gly Gln Ala 
                645                 650                 655     


Pro Val Ala Cys Glu Glu Thr Leu His Val Thr Asn Ile Thr Ile Leu 
            660                 665                 670         


Val Val Val Leu Val Leu Val Ile Val Gly Ile Gly Val Leu Ile Leu 
        675                 680                 685             


Leu Val Arg Tyr Arg Lys Cys Ile Lys Leu Lys Gln Val Gln Ser Pro 
    690                 695                 700                 


Pro Thr Glu Thr Leu Gly Val Glu Asn Lys Gly Tyr Phe Gly Asp Glu 
705                 710                 715                 720 


Gln Gln Ile Arg Thr Glu Pro Ile Leu Pro Glu Ile His Phe Leu Asn 
                725                 730                 735     


Lys Pro Ala Ser Lys Asp Ser Arg Gly Ile Ala Asp Pro Asn Gln Ser 
            740                 745                 750         


Ala Lys 
        


<210>  204
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM8__Homo_sapiens__NP_001100

<400>  204

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  205
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM9__Homo_sapiens__NP_003807

<400>  205

Met Gly Ser Gly Ala Arg Phe Pro Ser Gly Thr Leu Arg Val Arg Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Gly Pro Val Leu Gly Ala Ala Arg Pro 
            20                  25                  30          


Gly Phe Gln Gln Thr Ser His Leu Ser Ser Tyr Glu Ile Ile Thr Pro 
        35                  40                  45              


Trp Arg Leu Thr Arg Glu Arg Arg Glu Ala Pro Arg Pro Tyr Ser Lys 
    50                  55                  60                  


Gln Val Ser Tyr Val Ile Gln Ala Glu Gly Lys Glu His Ile Ile His 
65                  70                  75                  80  


Leu Glu Arg Asn Lys Asp Leu Leu Pro Glu Asp Phe Val Val Tyr Thr 
                85                  90                  95      


Tyr Asn Lys Glu Gly Thr Leu Ile Thr Asp His Pro Asn Ile Gln Asn 
            100                 105                 110         


His Cys His Tyr Arg Gly Tyr Val Glu Gly Val His Asn Ser Ser Ile 
        115                 120                 125             


Ala Leu Ser Asp Cys Phe Gly Leu Arg Gly Leu Leu His Leu Glu Asn 
    130                 135                 140                 


Ala Ser Tyr Gly Ile Glu Pro Leu Gln Asn Ser Ser His Phe Glu His 
145                 150                 155                 160 


Ile Ile Tyr Arg Met Asp Asp Val Tyr Lys Glu Pro Leu Lys Cys Gly 
                165                 170                 175     


Val Ser Asn Lys Asp Ile Glu Lys Glu Thr Ala Lys Asp Glu Glu Glu 
            180                 185                 190         


Glu Pro Pro Ser Met Thr Gln Leu Leu Arg Arg Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Thr Arg Tyr Val Glu Leu Phe Ile Val Val Asp Lys Glu Arg 
    210                 215                 220                 


Tyr Asp Met Met Gly Arg Asn Gln Thr Ala Val Arg Glu Glu Met Ile 
225                 230                 235                 240 


Leu Leu Ala Asn Tyr Leu Asp Ser Met Tyr Ile Met Leu Asn Ile Arg 
                245                 250                 255     


Ile Val Leu Val Gly Leu Glu Ile Trp Thr Asn Gly Asn Leu Ile Asn 
            260                 265                 270         


Ile Val Gly Gly Ala Gly Asp Val Leu Gly Asn Phe Val Gln Trp Arg 
        275                 280                 285             


Glu Lys Phe Leu Ile Thr Arg Arg Arg His Asp Ser Ala Gln Leu Val 
    290                 295                 300                 


Leu Lys Lys Gly Phe Gly Gly Thr Ala Gly Met Ala Phe Val Gly Thr 
305                 310                 315                 320 


Val Cys Ser Arg Ser His Ala Gly Gly Ile Asn Val Phe Gly Gln Ile 
                325                 330                 335     


Thr Val Glu Thr Phe Ala Ser Ile Val Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Leu Gly Met Asn His Asp Asp Gly Arg Asp Cys Ser Cys Gly Ala Lys 
        355                 360                 365             


Ser Cys Ile Met Asn Ser Gly Ala Ser Gly Ser Arg Asn Phe Ser Ser 
    370                 375                 380                 


Cys Ser Ala Glu Asp Phe Glu Lys Leu Thr Leu Asn Lys Gly Gly Asn 
385                 390                 395                 400 


Cys Leu Leu Asn Ile Pro Lys Pro Asp Glu Ala Tyr Ser Ala Pro Ser 
                405                 410                 415     


Cys Gly Asn Lys Leu Val Asp Ala Gly Glu Glu Cys Asp Cys Gly Thr 
            420                 425                 430         


Pro Lys Glu Cys Glu Leu Asp Pro Cys Cys Glu Gly Ser Thr Cys Lys 
        435                 440                 445             


Leu Lys Ser Phe Ala Glu Cys Ala Tyr Gly Asp Cys Cys Lys Asp Cys 
    450                 455                 460                 


Arg Phe Leu Pro Gly Gly Thr Leu Cys Arg Gly Lys Thr Ser Glu Cys 
465                 470                 475                 480 


Asp Val Pro Glu Tyr Cys Asn Gly Ser Ser Gln Phe Cys Gln Pro Asp 
                485                 490                 495     


Val Phe Ile Gln Asn Gly Tyr Pro Cys Gln Asn Asn Lys Ala Tyr Cys 
            500                 505                 510         


Tyr Asn Gly Met Cys Gln Tyr Tyr Asp Ala Gln Cys Gln Val Ile Phe 
        515                 520                 525             


Gly Ser Lys Ala Lys Ala Ala Pro Lys Asp Cys Phe Ile Glu Val Asn 
    530                 535                 540                 


Ser Lys Gly Asp Arg Phe Gly Asn Cys Gly Phe Ser Gly Asn Glu Tyr 
545                 550                 555                 560 


Lys Lys Cys Ala Thr Gly Asn Ala Leu Cys Gly Lys Leu Gln Cys Glu 
                565                 570                 575     


Asn Val Gln Glu Ile Pro Val Phe Gly Ile Val Pro Ala Ile Ile Gln 
            580                 585                 590         


Thr Pro Ser Arg Gly Thr Lys Cys Trp Gly Val Asp Phe Gln Leu Gly 
        595                 600                 605             


Ser Asp Val Pro Asp Pro Gly Met Val Asn Glu Gly Thr Lys Cys Gly 
    610                 615                 620                 


Ala Gly Lys Ile Cys Arg Asn Phe Gln Cys Val Asp Ala Ser Val Leu 
625                 630                 635                 640 


Asn Tyr Asp Cys Asp Val Gln Lys Lys Cys His Gly His Gly Val Cys 
                645                 650                 655     


Asn Ser Asn Lys Asn Cys His Cys Glu Asn Gly Trp Ala Pro Pro Asn 
            660                 665                 670         


Cys Glu Thr Lys Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Thr Tyr 
        675                 680                 685             


Asn Glu Met Asn Thr Ala Leu Arg Asp Gly Leu Leu Val Phe Phe Phe 
    690                 695                 700                 


Leu Ile Val Pro Leu Ile Val Cys Ala Ile Phe Ile Phe Ile Lys Arg 
705                 710                 715                 720 


Asp Gln Leu Trp Arg Ser Tyr Phe Arg Lys Lys Arg Ser Gln Thr Tyr 
                725                 730                 735     


Glu Ser Asp Gly Lys Asn Gln Ala Asn Pro Ser Arg Gln Pro Gly Ser 
            740                 745                 750         


Val Pro Arg His Val Ser Pro Val Thr Pro Pro Arg Glu Val Pro Ile 
        755                 760                 765             


Tyr Ala Asn Arg Phe Ala Val Pro Thr Tyr Ala Ala Lys Gln Pro Gln 
    770                 775                 780                 


Gln Phe Pro Ser Arg Pro Pro Pro Pro Gln Pro Lys Val Ser Ser Gln 
785                 790                 795                 800 


Gly Asn Leu Ile Pro Ala Arg Pro Ala Pro Ala Pro Pro Leu Tyr Ser 
                805                 810                 815     


Ser Leu Thr 
            


<210>  206
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMDEC1__Homo_sapiens__NP_001138743

<400>  206

Met Ile Leu Asn Gly Glu Glu Ile Ile Leu Ser Leu Gln Lys Thr Lys 
1               5                   10                  15      


His Leu Leu Gly Pro Asp Tyr Thr Glu Thr Leu Tyr Ser Pro Arg Gly 
            20                  25                  30          


Glu Glu Ile Thr Thr Lys Pro Glu Asn Met Glu His Cys Tyr Tyr Lys 
        35                  40                  45              


Gly Asn Ile Leu Asn Glu Lys Asn Ser Val Ala Ser Ile Ser Thr Cys 
    50                  55                  60                  


Asp Gly Leu Arg Gly Tyr Phe Thr His His His Gln Arg Tyr Gln Ile 
65                  70                  75                  80  


Lys Pro Leu Lys Ser Thr Asp Glu Lys Glu His Ala Val Phe Thr Ser 
                85                  90                  95      


Asn Gln Glu Glu Gln Asp Pro Ala Asn His Thr Cys Gly Val Lys Ser 
            100                 105                 110         


Thr Asp Gly Lys Gln Gly Pro Ile Arg Ile Ser Arg Ser Leu Lys Ser 
        115                 120                 125             


Pro Glu Lys Glu Asp Phe Leu Arg Ala Gln Lys Tyr Ile Asp Leu Tyr 
    130                 135                 140                 


Leu Val Leu Asp Asn Ala Phe Tyr Lys Asn Tyr Asn Glu Asn Leu Thr 
145                 150                 155                 160 


Leu Ile Arg Ser Phe Val Phe Asp Val Met Asn Leu Leu Asn Val Ile 
                165                 170                 175     


Tyr Asn Thr Ile Asp Val Gln Val Ala Leu Val Gly Met Glu Ile Trp 
            180                 185                 190         


Ser Asp Gly Asp Lys Ile Lys Val Val Pro Ser Ala Ser Thr Thr Phe 
        195                 200                 205             


Asp Asn Phe Leu Arg Trp His Ser Ser Asn Leu Gly Lys Lys Ile His 
    210                 215                 220                 


Asp His Ala Gln Leu Leu Ser Gly Ile Ser Phe Asn Asn Arg Arg Val 
225                 230                 235                 240 


Gly Leu Ala Ala Ser Asn Ser Leu Cys Ser Pro Ser Ser Val Ala Val 
                245                 250                 255     


Ile Glu Ala Lys Lys Lys Asn Asn Val Ala Leu Val Gly Val Met Ser 
            260                 265                 270         


His Glu Leu Gly His Val Leu Gly Met Pro Asp Val Pro Phe Asn Thr 
        275                 280                 285             


Lys Cys Pro Ser Gly Ser Cys Val Met Asn Gln Tyr Leu Ser Ser Lys 
    290                 295                 300                 


Phe Pro Lys Asp Phe Ser Thr Ser Cys Arg Ala His Phe Glu Arg Tyr 
305                 310                 315                 320 


Leu Leu Ser Gln Lys Pro Lys Cys Leu Leu Gln Ala Pro Ile Pro Thr 
                325                 330                 335     


Asn Ile Met Thr Thr Pro Val Cys Gly Asn His Leu Leu Glu Val Gly 
            340                 345                 350         


Glu Asp Cys Asp Cys Gly Ser Pro Lys Glu Cys Thr Asn Leu Cys Cys 
        355                 360                 365             


Glu Ala Leu Thr Cys Lys Leu Lys Pro Gly Thr Asp Cys Gly Gly Asp 
    370                 375                 380                 


Ala Pro Asn His Thr Thr Glu 
385                 390     


<210>  207
<211>  1103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS10__Homo_sapiens__NP_112219

<400>  207

Met Ala Pro Ala Cys Gln Ile Leu Arg Trp Ala Leu Ala Leu Gly Leu 
1               5                   10                  15      


Gly Leu Met Phe Glu Val Thr His Ala Phe Arg Ser Gln Asp Glu Phe 
            20                  25                  30          


Leu Ser Ser Leu Glu Ser Tyr Glu Ile Ala Phe Pro Thr Arg Val Asp 
        35                  40                  45              


His Asn Gly Ala Leu Leu Ala Phe Ser Pro Pro Pro Pro Arg Arg Gln 
    50                  55                  60                  


Arg Arg Gly Thr Gly Ala Thr Ala Glu Ser Arg Leu Phe Tyr Lys Val 
65                  70                  75                  80  


Ala Ser Pro Ser Thr His Phe Leu Leu Asn Leu Thr Arg Ser Ser Arg 
                85                  90                  95      


Leu Leu Ala Gly His Val Ser Val Glu Tyr Trp Thr Arg Glu Gly Leu 
            100                 105                 110         


Ala Trp Gln Arg Ala Ala Arg Pro His Cys Leu Tyr Ala Gly His Leu 
        115                 120                 125             


Gln Gly Gln Ala Ser Ser Ser His Val Ala Ile Ser Thr Cys Gly Gly 
    130                 135                 140                 


Leu His Gly Leu Ile Val Ala Asp Glu Glu Glu Tyr Leu Ile Glu Pro 
145                 150                 155                 160 


Leu His Gly Gly Pro Lys Gly Ser Arg Ser Pro Glu Glu Ser Gly Pro 
                165                 170                 175     


His Val Val Tyr Lys Arg Ser Ser Leu Arg His Pro His Leu Asp Thr 
            180                 185                 190         


Ala Cys Gly Val Arg Asp Glu Lys Pro Trp Lys Gly Arg Pro Trp Trp 
        195                 200                 205             


Leu Arg Thr Leu Lys Pro Pro Pro Ala Arg Pro Leu Gly Asn Glu Thr 
    210                 215                 220                 


Glu Arg Gly Gln Pro Gly Leu Lys Arg Ser Val Ser Arg Glu Arg Tyr 
225                 230                 235                 240 


Val Glu Thr Leu Val Val Ala Asp Lys Met Met Val Ala Tyr His Gly 
                245                 250                 255     


Arg Arg Asp Val Glu Gln Tyr Val Leu Ala Ile Met Asn Ile Val Ala 
            260                 265                 270         


Lys Leu Phe Gln Asp Ser Ser Leu Gly Ser Thr Val Asn Ile Leu Val 
        275                 280                 285             


Thr Arg Leu Ile Leu Leu Thr Glu Asp Gln Pro Thr Leu Glu Ile Thr 
    290                 295                 300                 


His His Ala Gly Lys Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser 
305                 310                 315                 320 


Ile Val Asn His Ser Gly His Gly Asn Ala Ile Pro Glu Asn Gly Val 
                325                 330                 335     


Ala Asn His Asp Thr Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Ile 
            340                 345                 350         


Tyr Lys Asn Lys Pro Cys Gly Thr Leu Gly Leu Ala Pro Val Gly Gly 
        355                 360                 365             


Met Cys Glu Arg Glu Arg Ser Cys Ser Val Asn Glu Asp Ile Gly Leu 
    370                 375                 380                 


Ala Thr Ala Phe Thr Ile Ala His Glu Ile Gly His Thr Phe Gly Met 
385                 390                 395                 400 


Asn His Asp Gly Val Gly Asn Ser Cys Gly Ala Arg Gly Gln Asp Pro 
                405                 410                 415     


Ala Lys Leu Met Ala Ala His Ile Thr Met Lys Thr Asn Pro Phe Val 
            420                 425                 430         


Trp Ser Ser Cys Ser Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly 
        435                 440                 445             


Leu Gly Leu Cys Leu Asn Asn Arg Pro Pro Arg Gln Asp Phe Val Tyr 
    450                 455                 460                 


Pro Thr Val Ala Pro Gly Gln Ala Tyr Asp Ala Asp Glu Gln Cys Arg 
465                 470                 475                 480 


Phe Gln His Gly Val Lys Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys 
                485                 490                 495     


Ser Glu Leu Trp Cys Leu Ser Lys Ser Asn Arg Cys Ile Thr Asn Ser 
            500                 505                 510         


Ile Pro Ala Ala Glu Gly Thr Leu Cys Gln Thr His Thr Ile Asp Lys 
        515                 520                 525             


Gly Trp Cys Tyr Lys Arg Val Cys Val Pro Phe Gly Ser Arg Pro Glu 
    530                 535                 540                 


Gly Val Asp Gly Ala Trp Gly Pro Trp Thr Pro Trp Gly Asp Cys Ser 
545                 550                 555                 560 


Arg Thr Cys Gly Gly Gly Val Ser Ser Ser Ser Arg His Cys Asp Ser 
                565                 570                 575     


Pro Arg Pro Thr Ile Gly Gly Lys Tyr Cys Leu Gly Glu Arg Arg Arg 
            580                 585                 590         


His Arg Ser Cys Asn Thr Asp Asp Cys Pro Pro Gly Ser Gln Asp Phe 
        595                 600                 605             


Arg Glu Val Gln Cys Ser Glu Phe Asp Ser Ile Pro Phe Arg Gly Lys 
    610                 615                 620                 


Phe Tyr Lys Trp Lys Thr Tyr Arg Gly Gly Gly Val Lys Ala Cys Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Ala Glu Gly Phe Asn Phe Tyr Thr Glu Arg Ala Ala 
                645                 650                 655     


Ala Val Val Asp Gly Thr Pro Cys Arg Pro Asp Thr Val Asp Ile Cys 
            660                 665                 670         


Val Ser Gly Glu Cys Lys His Val Gly Cys Asp Arg Val Leu Gly Ser 
        675                 680                 685             


Asp Leu Arg Glu Asp Lys Cys Arg Val Cys Gly Gly Asp Gly Ser Ala 
    690                 695                 700                 


Cys Glu Thr Ile Glu Gly Val Phe Ser Pro Ala Ser Pro Gly Ala Gly 
705                 710                 715                 720 


Tyr Glu Asp Val Val Trp Ile Pro Lys Gly Ser Val His Ile Phe Ile 
                725                 730                 735     


Gln Asp Leu Asn Leu Ser Leu Ser His Leu Ala Leu Lys Gly Asp Gln 
            740                 745                 750         


Glu Ser Leu Leu Leu Glu Gly Leu Pro Gly Thr Pro Gln Pro His Arg 
        755                 760                 765             


Leu Pro Leu Ala Gly Thr Thr Phe Gln Leu Arg Gln Gly Pro Asp Gln 
    770                 775                 780                 


Val Gln Ser Leu Glu Ala Leu Gly Pro Ile Asn Ala Ser Leu Ile Val 
785                 790                 795                 800 


Met Val Leu Ala Arg Thr Glu Leu Pro Ala Leu Arg Tyr Arg Phe Asn 
                805                 810                 815     


Ala Pro Ile Ala Arg Asp Ser Leu Pro Pro Tyr Ser Trp His Tyr Ala 
            820                 825                 830         


Pro Trp Thr Lys Cys Ser Ala Gln Cys Ala Gly Gly Ser Gln Val Gln 
        835                 840                 845             


Ala Val Glu Cys Arg Asn Gln Leu Asp Ser Ser Ala Val Ala Pro His 
    850                 855                 860                 


Tyr Cys Ser Ala His Ser Lys Leu Pro Lys Arg Gln Arg Ala Cys Asn 
865                 870                 875                 880 


Thr Glu Pro Cys Pro Pro Asp Trp Val Val Gly Asn Trp Ser Leu Cys 
                885                 890                 895     


Ser Arg Ser Cys Asp Ala Gly Val Arg Ser Arg Ser Val Val Cys Gln 
            900                 905                 910         


Arg Arg Val Ser Ala Ala Glu Glu Lys Ala Leu Asp Asp Ser Ala Cys 
        915                 920                 925             


Pro Gln Pro Arg Pro Pro Val Leu Glu Ala Cys His Gly Pro Thr Cys 
    930                 935                 940                 


Pro Pro Glu Trp Ala Ala Leu Asp Trp Ser Glu Cys Thr Pro Ser Cys 
945                 950                 955                 960 


Gly Pro Gly Leu Arg His Arg Val Val Leu Cys Lys Ser Ala Asp His 
                965                 970                 975     


Arg Ala Thr Leu Pro Pro Ala His Cys Ser Pro Ala Ala Lys Pro Pro 
            980                 985                 990         


Ala Thr Met Arg Cys Asn Leu Arg  Arg Cys Pro Pro Ala  Arg Trp Val 
        995                 1000                 1005             


Ala Gly  Glu Trp Gly Glu Cys  Ser Ala Gln Cys Gly  Val Gly Gln 
    1010                 1015                 1020             


Arg Gln  Arg Ser Val Arg Cys  Thr Ser His Thr Gly  Gln Ala Ser 
    1025                 1030                 1035             


His Glu  Cys Thr Glu Ala Leu  Arg Pro Pro Thr Thr  Gln Gln Cys 
    1040                 1045                 1050             


Glu Ala  Lys Cys Asp Ser Pro  Thr Pro Gly Asp Gly  Pro Glu Glu 
    1055                 1060                 1065             


Cys Lys  Asp Val Asn Lys Val  Ala Tyr Cys Pro Leu  Val Leu Lys 
    1070                 1075                 1080             


Phe Gln  Phe Cys Ser Arg Ala  Tyr Phe Arg Gln Met  Cys Cys Lys 
    1085                 1090                 1095             


Thr Cys  His Gly His 
    1100             


<210>  208
<211>  1594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS12__Homo_sapiens__NP_112217

<400>  208

Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys 
        195                 200                 205             


Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg 
    210                 215                 220                 


Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg 
225                 230                 235                 240 


Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val Val Ala Asp Thr 
                245                 250                 255     


Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu 
            260                 265                 270         


Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn Pro Ser Ile Gly 
        275                 280                 285             


Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu 
    290                 295                 300                 


Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Thr Leu Ser Ser 
305                 310                 315                 320 


Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro 
                325                 330                 335     


Val His His Asp Val Ala Val Leu Leu Thr Arg Lys Asp Ile Cys Ala 
            340                 345                 350         


Gly Phe Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Leu Ser Gly 
        355                 360                 365             


Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu 
    370                 375                 380                 


Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His Ser Phe Gly Ile 
385                 390                 395                 400 


Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro 
                405                 410                 415     


Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Thr Pro Leu Thr Trp 
            420                 425                 430         


Ser Lys Cys Ser Glu Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp 
        435                 440                 445             


Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys 
    450                 455                 460                 


Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu 
465                 470                 475                 480 


Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val Glu Asn Val Cys 
                485                 490                 495     


Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp 
            500                 505                 510         


Ala Ala Ala Asp Gly Thr Gln Cys Gly Glu Lys Lys Trp Cys Met Ala 
        515                 520                 525             


Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly 
    530                 535                 540                 


Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Thr Cys Gly Ala 
545                 550                 555                 560 


Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe 
                565                 570                 575     


Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn 
            580                 585                 590         


Val His Pro Cys Arg Ser Glu Ala Pro Thr Phe Arg Gln Met Gln Cys 
        595                 600                 605             


Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe 
    610                 615                 620                 


Pro Ile Phe Asn Pro Ala His Pro Cys Glu Leu Tyr Cys Arg Pro Ile 
625                 630                 635                 640 


Asp Gly Gln Phe Ser Glu Lys Met Leu Asp Ala Val Ile Asp Gly Thr 
                645                 650                 655     


Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys Ile Asn Gly Ile 
            660                 665                 670         


Cys Lys Met Val Gly Cys Asp Tyr Glu Ile Asp Ser Asn Ala Thr Glu 
        675                 680                 685             


Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ser Cys Gln Thr Val 
    690                 695                 700                 


Arg Lys Met Phe Lys Gln Lys Glu Gly Ser Gly Tyr Val Asp Ile Gly 
705                 710                 715                 720 


Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly 
                725                 730                 735     


Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr 
            740                 745                 750         


Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala 
        755                 760                 765             


Gly Thr Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met 
    770                 775                 780                 


Ala Thr Gly Pro Thr Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln 
785                 790                 795                 800 


Val Thr Asn Pro Gly Ile Lys Tyr Glu Tyr Thr Ile Gln Lys Asp Gly 
                805                 810                 815     


Leu Asp Asn Asp Val Glu Gln Gln Met Tyr Phe Trp Gln Tyr Gly His 
            820                 825                 830         


Trp Thr Glu Cys Ser Val Thr Cys Gly Thr Gly Ile Arg Arg Gln Thr 
        835                 840                 845             


Ala His Cys Ile Lys Lys Gly Arg Gly Met Val Lys Ala Thr Phe Cys 
    850                 855                 860                 


Asp Pro Glu Thr Gln Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys 
865                 870                 875                 880 


Ala Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala 
                885                 890                 895     


Thr Cys Gly Pro His Gly Glu Lys Lys Arg Thr Val Leu Cys Ile Gln 
            900                 905                 910         


Thr Met Val Ser Asp Glu Gln Ala Leu Pro Pro Thr Asp Cys Gln His 
        915                 920                 925             


Leu Leu Lys Pro Lys Thr Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys 
    930                 935                 940                 


Pro Ser Asp Trp Thr Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys 
945                 950                 955                 960 


Gly Gly Gly Val Arg Ile Arg Ser Val Thr Cys Ala Lys Asn His Asp 
                965                 970                 975     


Glu Pro Cys Asp Val Thr Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly 
            980                 985                 990         


Leu Gln Gln Cys Pro Ser Ser Arg  Arg Val Leu Lys Pro  Asn Lys Gly 
        995                 1000                 1005             


Thr Ile  Ser Asn Gly Lys Asn  Pro Pro Thr Leu Lys  Pro Val Pro 
    1010                 1015                 1020             


Pro Pro  Thr Ser Arg Pro Arg  Met Leu Thr Thr Pro  Thr Gly Pro 
    1025                 1030                 1035             


Glu Ser  Met Ser Thr Ser Thr  Pro Ala Ile Ser Ser  Pro Ser Pro 
    1040                 1045                 1050             


Thr Thr  Ala Ser Lys Glu Gly  Asp Leu Gly Gly Lys  Gln Trp Gln 
    1055                 1060                 1065             


Asp Ser  Ser Thr Gln Pro Glu  Leu Ser Ser Arg Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Thr Gly  Ser Thr Ser Gln Pro  Ile Leu Thr Ser Gln  Ser Leu Ser 
    1085                 1090                 1095             


Ile Gln  Pro Ser Glu Glu Asn  Val Ser Ser Ser Asp  Thr Gly Pro 
    1100                 1105                 1110             


Thr Ser  Glu Gly Gly Leu Val  Ala Thr Thr Thr Ser  Gly Ser Gly 
    1115                 1120                 1125             


Leu Ser  Ser Ser Arg Asn Pro  Ile Thr Trp Pro Val  Thr Pro Phe 
    1130                 1135                 1140             


Tyr Asn  Thr Leu Thr Lys Gly  Pro Glu Met Glu Ile  His Ser Gly 
    1145                 1150                 1155             


Ser Gly  Glu Glu Arg Glu Gln  Pro Glu Asp Lys Asp  Glu Ser Asn 
    1160                 1165                 1170             


Pro Val  Ile Trp Thr Lys Ile  Arg Val Pro Gly Asn  Asp Ala Pro 
    1175                 1180                 1185             


Val Glu  Ser Thr Glu Met Pro  Leu Ala Pro Pro Leu  Thr Pro Asp 
    1190                 1195                 1200             


Leu Ser  Arg Glu Ser Trp Trp  Pro Pro Phe Ser Thr  Val Met Glu 
    1205                 1210                 1215             


Gly Leu  Leu Pro Ser Gln Arg  Pro Thr Thr Ser Glu  Thr Gly Thr 
    1220                 1225                 1230             


Pro Arg  Val Glu Gly Met Val  Thr Glu Lys Pro Ala  Asn Thr Leu 
    1235                 1240                 1245             


Leu Pro  Leu Gly Gly Asp His  Gln Pro Glu Pro Ser  Gly Lys Thr 
    1250                 1255                 1260             


Ala Asn  Arg Asn His Leu Lys  Leu Pro Asn Asn Met  Asn Gln Thr 
    1265                 1270                 1275             


Lys Ser  Ser Glu Pro Val Leu  Thr Glu Glu Asp Ala  Thr Ser Leu 
    1280                 1285                 1290             


Ile Thr  Glu Gly Phe Leu Leu  Asn Ala Ser Asn Tyr  Lys Gln Leu 
    1295                 1300                 1305             


Thr Asn  Gly His Gly Ser Ala  His Trp Ile Val Gly  Asn Trp Ser 
    1310                 1315                 1320             


Glu Cys  Ser Thr Thr Cys Gly  Leu Gly Ala Tyr Trp  Arg Arg Val 
    1325                 1330                 1335             


Glu Cys  Ser Thr Gln Met Asp  Ser Asp Cys Ala Ala  Ile Gln Arg 
    1340                 1345                 1350             


Pro Asp  Pro Ala Lys Arg Cys  His Leu Arg Pro Cys  Ala Gly Trp 
    1355                 1360                 1365             


Lys Val  Gly Asn Trp Ser Lys  Cys Ser Arg Asn Cys  Ser Gly Gly 
    1370                 1375                 1380             


Phe Lys  Ile Arg Glu Ile Gln  Cys Val Asp Ser Arg  Asp His Arg 
    1385                 1390                 1395             


Asn Leu  Arg Pro Phe His Cys  Gln Phe Leu Ala Gly  Ile Pro Pro 
    1400                 1405                 1410             


Pro Leu  Ser Met Ser Cys Asn  Pro Glu Pro Cys Glu  Ala Trp Gln 
    1415                 1420                 1425             


Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser Cys Gly  Gly Gly Val 
    1430                 1435                 1440             


Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly Leu Cys  Asp Trp Thr 
    1445                 1450                 1455             


Lys Arg  Pro Thr Ser Thr Met  Ser Cys Asn Glu His  Leu Cys Cys 
    1460                 1465                 1470             


His Trp  Ala Thr Gly Asn Trp  Asp Leu Cys Ser Thr  Ser Cys Gly 
    1475                 1480                 1485             


Gly Gly  Phe Gln Lys Arg Thr  Val Gln Cys Val Pro  Ser Glu Gly 
    1490                 1495                 1500             


Asn Lys  Thr Glu Asp Gln Asp  Gln Cys Leu Cys Asp  His Lys Pro 
    1505                 1510                 1515             


Arg Pro  Pro Glu Phe Lys Lys  Cys Asn Gln Gln Ala  Cys Lys Lys 
    1520                 1525                 1530             


Ser Ala  Asp Leu Leu Cys Thr  Lys Asp Lys Leu Ser  Ala Ser Phe 
    1535                 1540                 1545             


Cys Gln  Thr Leu Lys Ala Met  Lys Lys Cys Ser Val  Pro Thr Val 
    1550                 1555                 1560             


Arg Ala  Glu Cys Cys Phe Ser  Cys Pro Gln Thr His  Ile Thr His 
    1565                 1570                 1575             


Thr Gln  Arg Gln Arg Arg Gln  Arg Leu Leu Gln Lys  Ser Lys Glu 
    1580                 1585                 1590             


Leu 
    


<210>  209
<211>  1427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS13__Homo_sapiens__NP_620594

<400>  209

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
    1415                 1420                 1425         


<210>  210
<211>  1223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS14__Homo_sapiens__NP_542453

<400>  210

Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys 
1               5                   10                  15      


Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser 
            20                  25                  30          


Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe 
        35                  40                  45              


Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser 
    50                  55                  60                  


Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser 
65                  70                  75                  80  


Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu 
                85                  90                  95      


Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val 
            100                 105                 110         


Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val 
        115                 120                 125             


Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe 
    130                 135                 140                 


Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly 
145                 150                 155                 160 


Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly 
                165                 170                 175     


Leu Ile Arg Thr Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg 
            180                 185                 190         


Gly Gln Gln Glu Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg 
        195                 200                 205             


Arg Glu Ala Val Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His 
    210                 215                 220                 


Asn Glu Ala Phe Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val 
225                 230                 235                 240 


Gly Asp Gln Leu Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro 
                245                 250                 255     


Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val 
            260                 265                 270         


Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met 
        275                 280                 285             


Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile 
    290                 295                 300                 


Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu 
305                 310                 315                 320 


Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys 
                325                 330                 335     


Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His 
            340                 345                 350         


His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly 
        355                 360                 365             


Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser Cys Ala Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala His Glu Thr 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Gly Cys Ala 
                405                 410                 415     


Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu Leu Ser Arg 
        435                 440                 445             


Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp Pro Ala 
    450                 455                 460                 


Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys Leu Ala Phe 
                485                 490                 495     


Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu 
        515                 520                 525             


Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile Trp Lys Ser 
    530                 535                 540                 


Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser Trp Thr Lys 
545                 550                 555                 560 


Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg Ser Arg Ser 
                565                 570                 575     


Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg Leu Cys Leu 
            580                 585                 590         


Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu Cys Pro Gly 
        595                 600                 605             


Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg Asn Ser Tyr 
    610                 615                 620                 


Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr Glu Pro Asp 
625                 630                 635                 640 


Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala Asp Thr Gly 
                645                 650                 655     


Asp Val Val Phe Met Asn Gln Val Val His Asp Gly Thr Arg Cys Ser 
            660                 665                 670         


Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys Val Pro Val 
        675                 680                 685             


Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp Lys Cys Gly 
    690                 695                 700                 


Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Leu 
705                 710                 715                 720 


Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val Gln Ile Pro 
                725                 730                 735     


Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys Ser Pro His 
            740                 745                 750         


Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile Leu Asn Pro 
        755                 760                 765             


Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met Gly Leu Glu 
    770                 775                 780                 


Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys Thr Ser Gly 
785                 790                 795                 800 


Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro Thr Glu Gly 
                805                 810                 815     


Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His Glu Asp Leu 
            820                 825                 830         


Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu Met Asp Thr 
        835                 840                 845             


Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys Ala Cys Gly 
    850                 855                 860                 


Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg Arg Asp His 
865                 870                 875                 880 


His Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg Pro Lys Pro 
                885                 890                 895     


Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro Val Trp Val 
            900                 905                 910         


Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys Leu Gly Val 
        915                 920                 925             


Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn Gly Thr His 
    930                 935                 940                 


Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro Glu Ala Arg 
945                 950                 955                 960 


Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg Leu Gly Ala 
                965                 970                 975     


Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln Gln Arg Gln 
            980                 985                 990         


Val Val Cys Arg Thr Asn Ala Asn  Ser Leu Gly His Cys  Glu Gly Asp 
        995                 1000                 1005             


Arg Pro  Asp Thr Val Gln Val  Cys Ser Leu Pro Ala  Cys Gly Gly 
    1010                 1015                 1020             


Asn His  Gln Asn Ser Thr Val  Arg Ala Asp Val Trp  Glu Leu Gly 
    1025                 1030                 1035             


Thr Pro  Glu Gly Gln Trp Val  Pro Gln Ser Glu Pro  Leu His Pro 
    1040                 1045                 1050             


Ile Asn  Lys Ile Ser Ser Thr  Glu Pro Cys Thr Gly  Asp Arg Ser 
    1055                 1060                 1065             


Val Phe  Cys Gln Met Glu Val  Leu Asp Arg Tyr Cys  Ser Ile Pro 
    1070                 1075                 1080             


Gly Tyr  His Arg Leu Cys Cys  Val Ser Cys Ile Lys  Lys Ala Ser 
    1085                 1090                 1095             


Gly Pro  Asn Pro Gly Pro Asp  Pro Gly Pro Thr Ser  Leu Pro Pro 
    1100                 1105                 1110             


Phe Ser  Thr Pro Gly Ser Pro  Leu Pro Gly Pro Gln  Asp Pro Ala 
    1115                 1120                 1125             


Asp Ala  Ala Glu Pro Pro Gly  Lys Pro Thr Gly Ser  Glu Asp His 
    1130                 1135                 1140             


Gln His  Gly Arg Ala Thr Gln  Leu Pro Gly Ala Leu  Asp Thr Ser 
    1145                 1150                 1155             


Ser Pro  Gly Thr Gln His Pro  Phe Ala Pro Glu Thr  Pro Ile Pro 
    1160                 1165                 1170             


Gly Ala  Ser Trp Ser Ile Ser  Pro Thr Thr Pro Gly  Gly Leu Pro 
    1175                 1180                 1185             


Trp Gly  Trp Thr Gln Thr Pro  Thr Pro Val Pro Glu  Asp Lys Gly 
    1190                 1195                 1200             


Gln Pro  Gly Glu Asp Leu Arg  His Pro Gly Thr Ser  Leu Pro Ala 
    1205                 1210                 1215             


Ala Ser  Pro Val Thr 
    1220             


<210>  211
<211>  950
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS15__Homo_sapiens__NP_620686

<400>  211

Met Leu Leu Leu Gly Ile Leu Thr Leu Ala Phe Ala Gly Arg Thr Ala 
1               5                   10                  15      


Gly Gly Ser Glu Pro Glu Arg Glu Val Val Val Pro Ile Arg Leu Asp 
            20                  25                  30          


Pro Asp Ile Asn Gly Arg Arg Tyr Tyr Trp Arg Gly Pro Glu Asp Ser 
        35                  40                  45              


Gly Asp Gln Gly Leu Ile Phe Gln Ile Thr Ala Phe Gln Glu Asp Phe 
    50                  55                  60                  


Tyr Leu His Leu Thr Pro Asp Ala Gln Phe Leu Ala Pro Ala Phe Ser 
65                  70                  75                  80  


Thr Glu His Leu Gly Val Pro Leu Gln Gly Leu Thr Gly Gly Ser Ser 
                85                  90                  95      


Asp Leu Arg Arg Cys Phe Tyr Ser Gly Asp Val Asn Ala Glu Pro Asp 
            100                 105                 110         


Ser Phe Ala Ala Val Ser Leu Cys Gly Gly Leu Arg Gly Ala Phe Gly 
        115                 120                 125             


Tyr Arg Gly Ala Glu Tyr Val Ile Ser Pro Leu Pro Asn Ala Ser Ala 
    130                 135                 140                 


Pro Ala Ala Gln Arg Asn Ser Gln Gly Ala His Leu Leu Gln Arg Arg 
145                 150                 155                 160 


Gly Val Pro Gly Gly Pro Ser Gly Asp Pro Thr Ser Arg Cys Gly Val 
                165                 170                 175     


Ala Ser Gly Trp Asn Pro Ala Ile Leu Arg Ala Leu Asp Pro Tyr Lys 
            180                 185                 190         


Pro Arg Arg Ala Gly Phe Gly Glu Ser Arg Ser Arg Arg Arg Ser Gly 
        195                 200                 205             


Arg Ala Lys Arg Phe Val Ser Ile Pro Arg Tyr Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Glu Ser Met Val Lys Phe His Gly Ala Asp Leu Glu His 
225                 230                 235                 240 


Tyr Leu Leu Thr Leu Leu Ala Thr Ala Ala Arg Leu Tyr Arg His Pro 
                245                 250                 255     


Ser Ile Leu Asn Pro Ile Asn Ile Val Val Val Lys Val Leu Leu Leu 
            260                 265                 270         


Arg Asp Arg Asp Ser Gly Pro Lys Val Thr Gly Asn Ala Ala Leu Thr 
        275                 280                 285             


Leu Arg Asn Phe Cys Ala Trp Gln Lys Lys Leu Asn Lys Val Ser Asp 
    290                 295                 300                 


Lys His Pro Glu Tyr Trp Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Ala Thr Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Met Cys Asp Pro Lys Arg Ser Cys Ser Val Ile Glu Asp Asp Gly 
            340                 345                 350         


Leu Pro Ser Ala Phe Thr Thr Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Pro His Asp Asn Val Lys Val Cys Glu Glu Val Phe Gly Lys Leu 
    370                 375                 380                 


Arg Ala Asn His Met Met Ser Pro Thr Leu Ile Gln Ile Asp Arg Ala 
385                 390                 395                 400 


Asn Pro Trp Ser Ala Cys Ser Ala Ala Ile Ile Thr Asp Phe Leu Asp 
                405                 410                 415     


Ser Gly His Gly Asp Cys Leu Leu Asp Gln Pro Ser Lys Pro Ile Ser 
            420                 425                 430         


Leu Pro Glu Asp Leu Pro Gly Ala Ser Tyr Thr Leu Ser Gln Gln Cys 
        435                 440                 445             


Glu Leu Ala Phe Gly Val Gly Ser Lys Pro Cys Pro Tyr Met Gln Tyr 
    450                 455                 460                 


Cys Thr Lys Leu Trp Cys Thr Gly Lys Ala Lys Gly Gln Met Val Cys 
465                 470                 475                 480 


Gln Thr Arg His Phe Pro Trp Ala Asp Gly Thr Ser Cys Gly Glu Gly 
                485                 490                 495     


Lys Leu Cys Leu Lys Gly Ala Cys Val Glu Arg His Asn Leu Asn Lys 
            500                 505                 510         


His Arg Val Asp Gly Ser Trp Ala Lys Trp Asp Pro Tyr Gly Pro Cys 
        515                 520                 525             


Ser Arg Thr Cys Gly Gly Gly Val Gln Leu Ala Arg Arg Gln Cys Thr 
    530                 535                 540                 


Asn Pro Thr Pro Ala Asn Gly Gly Lys Tyr Cys Glu Gly Val Arg Val 
545                 550                 555                 560 


Lys Tyr Arg Ser Cys Asn Leu Glu Pro Cys Pro Ser Ser Ala Ser Gly 
                565                 570                 575     


Lys Ser Phe Arg Glu Glu Gln Cys Glu Ala Phe Asn Gly Tyr Asn His 
            580                 585                 590         


Ser Thr Asn Arg Leu Thr Leu Ala Val Ala Trp Val Pro Lys Tyr Ser 
        595                 600                 605             


Gly Val Ser Pro Arg Asp Lys Cys Lys Leu Ile Cys Arg Ala Asn Gly 
    610                 615                 620                 


Thr Gly Tyr Phe Tyr Val Leu Ala Pro Lys Val Val Asp Gly Thr Leu 
625                 630                 635                 640 


Cys Ser Pro Asp Ser Thr Ser Val Cys Val Gln Gly Lys Cys Ile Lys 
                645                 650                 655     


Ala Gly Cys Asp Gly Asn Leu Gly Ser Lys Lys Arg Phe Asp Lys Cys 
            660                 665                 670         


Gly Val Cys Gly Gly Asp Asn Lys Ser Cys Lys Lys Val Thr Gly Leu 
        675                 680                 685             


Phe Thr Lys Pro Met His Gly Tyr Asn Phe Val Val Ala Ile Pro Ala 
    690                 695                 700                 


Gly Ala Ser Ser Ile Asp Ile Arg Gln Arg Gly Tyr Lys Gly Leu Ile 
705                 710                 715                 720 


Gly Asp Asp Asn Tyr Leu Ala Leu Lys Asn Ser Gln Gly Lys Tyr Leu 
                725                 730                 735     


Leu Asn Gly His Phe Val Val Ser Ala Val Glu Arg Asp Leu Val Val 
            740                 745                 750         


Lys Gly Ser Leu Leu Arg Tyr Ser Gly Thr Gly Thr Ala Val Glu Ser 
        755                 760                 765             


Leu Gln Ala Ser Arg Pro Ile Leu Glu Pro Leu Thr Val Glu Val Leu 
    770                 775                 780                 


Ser Val Gly Lys Met Thr Pro Pro Arg Val Arg Tyr Ser Phe Tyr Leu 
785                 790                 795                 800 


Pro Lys Glu Pro Arg Glu Asp Lys Ser Ser His Pro Lys Asp Pro Arg 
                805                 810                 815     


Gly Pro Ser Val Leu His Asn Ser Val Leu Ser Leu Ser Asn Gln Val 
            820                 825                 830         


Glu Gln Pro Asp Asp Arg Pro Pro Ala Arg Trp Val Ala Gly Ser Trp 
        835                 840                 845             


Gly Pro Cys Ser Ala Ser Cys Gly Ser Gly Leu Gln Lys Arg Ala Val 
    850                 855                 860                 


Asp Cys Arg Gly Ser Ala Gly Gln Arg Thr Val Pro Ala Cys Asp Ala 
865                 870                 875                 880 


Ala His Arg Pro Val Glu Thr Gln Ala Cys Gly Glu Pro Cys Pro Thr 
                885                 890                 895     


Trp Glu Leu Ser Ala Trp Ser Pro Cys Ser Lys Ser Cys Gly Arg Gly 
            900                 905                 910         


Phe Gln Arg Arg Ser Leu Lys Cys Val Gly His Gly Gly Arg Leu Leu 
        915                 920                 925             


Ala Arg Asp Gln Cys Asn Leu His Arg Lys Pro Gln Glu Leu Asp Phe 
    930                 935                 940                 


Cys Val Leu Arg Pro Cys 
945                 950 


<210>  212
<211>  1224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS16__Homo_sapiens__NP_620687

<400>  212

Met Lys Pro Arg Ala Arg Gly Trp Arg Gly Leu Ala Ala Leu Trp Met 
1               5                   10                  15      


Leu Leu Ala Gln Val Ala Glu Gln Ala Pro Ala Cys Ala Met Gly Pro 
            20                  25                  30          


Ala Ala Ala Ala Pro Gly Ser Pro Ser Val Pro Arg Pro Pro Pro Pro 
        35                  40                  45              


Ala Glu Arg Pro Gly Trp Met Glu Lys Gly Glu Tyr Asp Leu Val Ser 
    50                  55                  60                  


Ala Tyr Glu Val Asp His Arg Gly Asp Tyr Val Ser His Glu Ile Met 
65                  70                  75                  80  


His His Gln Arg Arg Arg Arg Ala Val Pro Val Ser Glu Val Glu Ser 
                85                  90                  95      


Leu His Leu Arg Leu Lys Gly Ser Arg His Asp Phe His Met Asp Leu 
            100                 105                 110         


Arg Thr Ser Ser Ser Leu Val Ala Pro Gly Phe Ile Val Gln Thr Leu 
        115                 120                 125             


Gly Lys Thr Gly Thr Lys Ser Val Gln Thr Leu Pro Pro Glu Asp Phe 
    130                 135                 140                 


Cys Phe Tyr Gln Gly Ser Leu Arg Ser His Arg Asn Ser Ser Val Ala 
145                 150                 155                 160 


Leu Ser Thr Cys Gln Gly Leu Ser Gly Met Ile Arg Thr Glu Glu Ala 
                165                 170                 175     


Asp Tyr Phe Leu Arg Pro Leu Pro Ser His Leu Ser Trp Lys Leu Gly 
            180                 185                 190         


Arg Ala Ala Gln Gly Ser Ser Pro Ser His Val Leu Tyr Lys Arg Ser 
        195                 200                 205             


Thr Glu Pro His Ala Pro Gly Ala Ser Glu Val Leu Val Thr Ser Arg 
    210                 215                 220                 


Thr Trp Glu Leu Ala His Gln Pro Leu His Ser Ser Asp Leu Arg Leu 
225                 230                 235                 240 


Gly Leu Pro Gln Lys Gln His Phe Cys Gly Arg Arg Lys Lys Tyr Met 
                245                 250                 255     


Pro Gln Pro Pro Lys Glu Asp Leu Phe Ile Leu Pro Asp Glu Tyr Lys 
            260                 265                 270         


Ser Cys Leu Arg His Lys Arg Ser Leu Leu Arg Ser His Arg Asn Glu 
        275                 280                 285             


Glu Leu Asn Val Glu Thr Leu Val Val Val Asp Lys Lys Met Met Gln 
    290                 295                 300                 


Asn His Gly His Glu Asn Ile Thr Thr Tyr Val Leu Thr Ile Leu Asn 
305                 310                 315                 320 


Met Val Ser Ala Leu Phe Lys Asp Gly Thr Ile Gly Gly Asn Ile Asn 
                325                 330                 335     


Ile Ala Ile Val Gly Leu Ile Leu Leu Glu Asp Glu Gln Pro Gly Leu 
            340                 345                 350         


Val Ile Ser His His Ala Asp His Thr Leu Ser Ser Phe Cys Gln Trp 
        355                 360                 365             


Gln Ser Gly Leu Met Gly Lys Asp Gly Thr Arg His Asp His Ala Ile 
    370                 375                 380                 


Leu Leu Thr Gly Leu Asp Ile Cys Ser Trp Lys Asn Glu Pro Cys Asp 
385                 390                 395                 400 


Thr Leu Gly Phe Ala Pro Ile Ser Gly Met Cys Ser Lys Tyr Arg Ser 
                405                 410                 415     


Cys Thr Ile Asn Glu Asp Thr Gly Leu Gly Leu Ala Phe Thr Ile Ala 
            420                 425                 430         


His Glu Ser Gly His Asn Phe Gly Met Ile His Asp Gly Glu Gly Asn 
        435                 440                 445             


Met Cys Lys Lys Ser Glu Gly Asn Ile Met Ser Pro Thr Leu Ala Gly 
    450                 455                 460                 


Arg Asn Gly Val Phe Ser Trp Ser Pro Cys Ser Arg Gln Tyr Leu His 
465                 470                 475                 480 


Lys Phe Leu Ser Thr Ala Gln Ala Ile Cys Leu Ala Asp Gln Pro Lys 
                485                 490                 495     


Pro Val Lys Glu Tyr Lys Tyr Pro Glu Lys Leu Pro Gly Glu Leu Tyr 
            500                 505                 510         


Asp Ala Asn Thr Gln Cys Lys Trp Gln Phe Gly Glu Lys Ala Lys Leu 
        515                 520                 525             


Cys Met Leu Asp Phe Lys Lys Asp Ile Cys Lys Ala Leu Trp Cys His 
    530                 535                 540                 


Arg Ile Gly Arg Lys Cys Glu Thr Lys Phe Met Pro Ala Ala Glu Gly 
545                 550                 555                 560 


Thr Ile Cys Gly His Asp Met Trp Cys Arg Gly Gly Gln Cys Val Lys 
                565                 570                 575     


Tyr Gly Asp Glu Gly Pro Lys Pro Thr His Gly His Trp Ser Asp Trp 
            580                 585                 590         


Ser Ser Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser His 
        595                 600                 605             


Arg Ser Arg Leu Cys Thr Asn Pro Lys Pro Ser His Gly Gly Lys Phe 
    610                 615                 620                 


Cys Glu Gly Ser Thr Arg Thr Leu Lys Leu Cys Asn Ser Gln Lys Cys 
625                 630                 635                 640 


Pro Arg Asp Ser Val Asp Phe Arg Ala Ala Gln Cys Ala Glu His Asn 
                645                 650                 655     


Ser Arg Arg Phe Arg Gly Arg His Tyr Lys Trp Lys Pro Tyr Thr Gln 
            660                 665                 670         


Val Glu Asp Gln Asp Leu Cys Lys Leu Tyr Cys Ile Ala Glu Gly Phe 
        675                 680                 685             


Asp Phe Phe Phe Ser Leu Ser Asn Lys Val Lys Asp Gly Thr Pro Cys 
    690                 695                 700                 


Ser Glu Asp Ser Arg Asn Val Cys Ile Asp Gly Ile Cys Glu Arg Val 
705                 710                 715                 720 


Gly Cys Asp Asn Val Leu Gly Ser Asp Ala Val Glu Asp Val Cys Gly 
                725                 730                 735     


Val Cys Asn Gly Asn Asn Ser Ala Cys Thr Ile His Arg Gly Leu Tyr 
            740                 745                 750         


Thr Lys His His His Thr Asn Gln Tyr Tyr His Met Val Thr Ile Pro 
        755                 760                 765             


Ser Gly Ala Arg Ser Ile Arg Ile Tyr Glu Met Asn Val Ser Thr Ser 
    770                 775                 780                 


Tyr Ile Ser Val Arg Asn Ala Leu Arg Arg Tyr Tyr Leu Asn Gly His 
785                 790                 795                 800 


Trp Thr Val Asp Trp Pro Gly Arg Tyr Lys Phe Ser Gly Thr Thr Phe 
                805                 810                 815     


Asp Tyr Arg Arg Ser Tyr Asn Glu Pro Glu Asn Leu Ile Ala Thr Gly 
            820                 825                 830         


Pro Thr Asn Glu Thr Leu Ile Val Glu Leu Leu Phe Gln Gly Arg Asn 
        835                 840                 845             


Pro Gly Val Ala Trp Glu Tyr Ser Met Pro Arg Leu Gly Thr Glu Lys 
    850                 855                 860                 


Gln Pro Pro Ala Gln Pro Ser Tyr Thr Trp Ala Ile Val Arg Ser Glu 
865                 870                 875                 880 


Cys Ser Val Ser Cys Gly Gly Gly Gln Met Thr Val Arg Glu Gly Cys 
                885                 890                 895     


Tyr Arg Asp Leu Lys Phe Gln Val Asn Met Ser Phe Cys Asn Pro Lys 
            900                 905                 910         


Thr Arg Pro Val Thr Gly Leu Val Pro Cys Lys Val Ser Ala Cys Pro 
        915                 920                 925             


Pro Ser Trp Ser Val Gly Asn Trp Ser Ala Cys Ser Arg Thr Cys Gly 
    930                 935                 940                 


Gly Gly Ala Gln Ser Arg Pro Val Gln Cys Thr Arg Arg Val His Tyr 
945                 950                 955                 960 


Asp Ser Glu Pro Val Pro Ala Ser Leu Cys Pro Gln Pro Ala Pro Ser 
                965                 970                 975     


Ser Arg Gln Ala Cys Asn Ser Gln Ser Cys Pro Pro Ala Trp Ser Ala 
            980                 985                 990         


Gly Pro Trp Ala Glu Cys Ser His  Thr Cys Gly Lys Gly  Trp Arg Lys 
        995                 1000                 1005             


Arg Ala  Val Ala Cys Lys Ser  Thr Asn Pro Ser Ala  Arg Ala Gln 
    1010                 1015                 1020             


Leu Leu  Pro Asp Ala Val Cys  Thr Ser Glu Pro Lys  Pro Arg Met 
    1025                 1030                 1035             


His Glu  Ala Cys Leu Leu Gln  Arg Cys His Lys Pro  Lys Lys Leu 
    1040                 1045                 1050             


Gln Trp  Leu Val Ser Ala Trp  Ser Gln Cys Ser Val  Thr Cys Glu 
    1055                 1060                 1065             


Arg Gly  Thr Gln Lys Arg Phe  Leu Lys Cys Ala Glu  Lys Tyr Val 
    1070                 1075                 1080             


Ser Gly  Lys Tyr Arg Glu Leu  Ala Ser Lys Lys Cys  Ser His Leu 
    1085                 1090                 1095             


Pro Lys  Pro Ser Leu Glu Leu  Glu Arg Ala Cys Ala  Pro Leu Pro 
    1100                 1105                 1110             


Cys Pro  Arg His Pro Pro Phe  Ala Ala Ala Gly Pro  Ser Arg Gly 
    1115                 1120                 1125             


Ser Trp  Phe Ala Ser Pro Trp  Ser Gln Cys Thr Ala  Ser Cys Gly 
    1130                 1135                 1140             


Gly Gly  Val Gln Thr Arg Ser  Val Gln Cys Leu Ala  Gly Gly Arg 
    1145                 1150                 1155             


Pro Ala  Ser Gly Cys Leu Leu  His Gln Lys Pro Ser  Ala Ser Leu 
    1160                 1165                 1170             


Ala Cys  Asn Thr His Phe Cys  Pro Ile Ala Glu Lys  Lys Asp Ala 
    1175                 1180                 1185             


Phe Cys  Lys Asp Tyr Phe His  Trp Cys Tyr Leu Val  Pro Gln His 
    1190                 1195                 1200             


Gly Met  Cys Ser His Lys Phe  Tyr Gly Lys Gln Cys  Cys Lys Thr 
    1205                 1210                 1215             


Cys Ser  Lys Ser Asn Leu 
    1220                 


<210>  213
<211>  1095
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS17__Homo_sapiens__NP_620688

<400>  213

Met Cys Asp Gly Ala Leu Leu Pro Pro Leu Val Leu Pro Val Leu Leu 
1               5                   10                  15      


Leu Leu Val Trp Gly Leu Asp Pro Gly Thr Ala Val Gly Asp Ala Ala 
            20                  25                  30          


Ala Asp Val Glu Val Val Leu Pro Trp Arg Val Arg Pro Asp Asp Val 
        35                  40                  45              


His Leu Pro Pro Leu Pro Ala Ala Pro Gly Pro Arg Arg Arg Arg Arg 
    50                  55                  60                  


Pro Arg Thr Pro Pro Ala Ala Pro Arg Ala Arg Pro Gly Glu Arg Ala 
65                  70                  75                  80  


Leu Leu Leu His Leu Pro Ala Phe Gly Arg Asp Leu Tyr Leu Gln Leu 
                85                  90                  95      


Arg Arg Asp Leu Arg Phe Leu Ser Arg Gly Phe Glu Val Glu Glu Ala 
            100                 105                 110         


Gly Ala Ala Arg Arg Arg Gly Arg Pro Ala Glu Leu Cys Phe Tyr Ser 
        115                 120                 125             


Gly Arg Val Leu Gly His Pro Gly Ser Leu Val Ser Leu Ser Ala Cys 
    130                 135                 140                 


Gly Ala Ala Gly Gly Leu Val Gly Leu Ile Gln Leu Gly Gln Glu Gln 
145                 150                 155                 160 


Val Leu Ile Gln Pro Leu Asn Asn Ser Gln Gly Pro Phe Ser Gly Arg 
                165                 170                 175     


Glu His Leu Ile Arg Arg Lys Trp Ser Leu Thr Pro Ser Pro Ser Ala 
            180                 185                 190         


Glu Ala Gln Arg Pro Glu Gln Leu Cys Lys Val Leu Thr Glu Lys Lys 
        195                 200                 205             


Lys Pro Thr Trp Gly Arg Pro Ser Arg Asp Trp Arg Glu Arg Arg Asn 
    210                 215                 220                 


Ala Ile Arg Leu Thr Ser Glu His Thr Val Glu Thr Leu Val Val Ala 
225                 230                 235                 240 


Asp Ala Asp Met Val Gln Tyr His Gly Ala Glu Ala Ala Gln Arg Phe 
                245                 250                 255     


Ile Leu Thr Val Met Asn Met Val Tyr Asn Met Phe Gln His Gln Ser 
            260                 265                 270         


Leu Gly Ile Lys Ile Asn Ile Gln Val Thr Lys Leu Val Leu Leu Arg 
        275                 280                 285             


Gln Arg Pro Ala Lys Leu Ser Ile Gly His His Gly Glu Arg Ser Leu 
    290                 295                 300                 


Glu Ser Phe Cys His Trp Gln Asn Glu Glu Tyr Gly Gly Ala Arg Tyr 
305                 310                 315                 320 


Leu Gly Asn Asn Gln Val Pro Gly Gly Lys Asp Asp Pro Pro Leu Val 
                325                 330                 335     


Asp Ala Ala Val Phe Val Thr Arg Thr Asp Phe Cys Val His Lys Asp 
            340                 345                 350         


Glu Pro Cys Asp Thr Val Gly Ile Ala Tyr Leu Gly Gly Val Cys Ser 
        355                 360                 365             


Ala Lys Arg Lys Cys Val Leu Ala Glu Asp Asn Gly Leu Asn Leu Ala 
    370                 375                 380                 


Phe Thr Ile Ala His Glu Leu Gly His Asn Leu Gly Met Asn His Asp 
385                 390                 395                 400 


Asp Asp His Ser Ser Cys Ala Gly Arg Ser His Ile Met Ser Gly Glu 
                405                 410                 415     


Trp Val Lys Gly Arg Asn Pro Ser Asp Leu Ser Trp Ser Ser Cys Ser 
            420                 425                 430         


Arg Asp Asp Leu Glu Asn Phe Leu Lys Ser Lys Val Ser Thr Cys Leu 
        435                 440                 445             


Leu Val Thr Asp Pro Arg Ser Gln His Thr Val Arg Leu Pro His Lys 
    450                 455                 460                 


Leu Pro Gly Met His Tyr Ser Ala Asn Glu Gln Cys Gln Ile Leu Phe 
465                 470                 475                 480 


Gly Met Asn Ala Thr Phe Cys Arg Asn Met Glu His Leu Met Cys Ala 
                485                 490                 495     


Gly Leu Trp Cys Leu Val Glu Gly Asp Thr Ser Cys Lys Thr Lys Leu 
            500                 505                 510         


Asp Pro Pro Leu Asp Gly Thr Glu Cys Gly Ala Asp Lys Trp Cys Arg 
        515                 520                 525             


Ala Gly Glu Cys Val Ser Lys Thr Pro Ile Pro Glu His Val Asp Gly 
    530                 535                 540                 


Asp Trp Ser Pro Trp Gly Ala Trp Ser Met Cys Ser Arg Thr Cys Gly 
545                 550                 555                 560 


Thr Gly Ala Arg Phe Arg Gln Arg Lys Cys Asp Asn Pro Pro Pro Gly 
                565                 570                 575     


Pro Gly Gly Thr His Cys Pro Gly Ala Ser Val Glu His Ala Val Cys 
            580                 585                 590         


Glu Asn Leu Pro Cys Pro Lys Gly Leu Pro Ser Phe Arg Asp Gln Gln 
        595                 600                 605             


Cys Gln Ala His Asp Arg Leu Ser Pro Lys Lys Lys Gly Leu Leu Thr 
    610                 615                 620                 


Ala Val Val Val Asp Asp Lys Pro Cys Glu Leu Tyr Cys Ser Pro Leu 
625                 630                 635                 640 


Gly Lys Glu Ser Pro Leu Leu Val Ala Asp Arg Val Leu Asp Gly Thr 
                645                 650                 655     


Pro Cys Gly Pro Tyr Glu Thr Asp Leu Cys Val His Gly Lys Cys Gln 
            660                 665                 670         


Lys Ile Gly Cys Asp Gly Ile Ile Gly Ser Ala Ala Lys Glu Asp Arg 
        675                 680                 685             


Cys Gly Val Cys Ser Gly Asp Gly Lys Thr Cys His Leu Val Lys Gly 
    690                 695                 700                 


Asp Phe Ser His Ala Arg Gly Thr Ala Leu Lys Asp Ser Gly Lys Gly 
705                 710                 715                 720 


Ser Ile Asn Ser Asp Trp Lys Ile Glu Leu Pro Gly Glu Phe Gln Ile 
                725                 730                 735     


Ala Gly Thr Thr Val Arg Tyr Val Arg Arg Gly Leu Trp Glu Lys Ile 
            740                 745                 750         


Ser Ala Lys Gly Pro Thr Lys Leu Pro Leu His Leu Met Val Leu Leu 
        755                 760                 765             


Phe His Asp Gln Asp Tyr Gly Ile His Tyr Glu Tyr Thr Val Pro Val 
    770                 775                 780                 


Asn Arg Thr Ala Glu Asn Gln Ser Glu Pro Glu Lys Pro Gln Asp Ser 
785                 790                 795                 800 


Leu Phe Ile Trp Thr His Ser Gly Trp Glu Gly Cys Ser Val Gln Cys 
                805                 810                 815     


Gly Gly Gly Glu Arg Arg Thr Ile Val Ser Cys Thr Arg Ile Val Asn 
            820                 825                 830         


Lys Thr Thr Thr Leu Val Asn Asp Ser Asp Cys Pro Gln Ala Ser Arg 
        835                 840                 845             


Pro Glu Pro Gln Val Arg Arg Cys Asn Leu His Pro Cys Gln Ser Arg 
    850                 855                 860                 


Trp Val Ala Gly Pro Trp Ser Pro Cys Ser Ala Thr Cys Glu Lys Gly 
865                 870                 875                 880 


Phe Gln His Arg Glu Val Thr Cys Val Tyr Gln Leu Gln Asn Gly Thr 
                885                 890                 895     


His Val Ala Thr Arg Pro Leu Tyr Cys Pro Gly Pro Arg Pro Ala Ala 
            900                 905                 910         


Val Gln Ser Cys Glu Gly Gln Asp Cys Leu Ser Ile Trp Glu Ala Ser 
        915                 920                 925             


Glu Trp Ser Gln Cys Ser Ala Ser Cys Gly Lys Gly Val Trp Lys Arg 
    930                 935                 940                 


Thr Val Ala Cys Thr Asn Ser Gln Gly Lys Cys Asp Ala Ser Thr Arg 
945                 950                 955                 960 


Pro Arg Ala Glu Glu Ala Cys Glu Asp Tyr Ser Gly Cys Tyr Glu Trp 
                965                 970                 975     


Lys Thr Gly Asp Trp Ser Thr Cys Ser Ser Thr Cys Gly Lys Gly Leu 
            980                 985                 990         


Gln Ser Arg Val Val Gln Cys Met  His Lys Val Thr Gly  Arg His Gly 
        995                 1000                 1005             


Ser Glu  Cys Pro Ala Leu Ser  Lys Pro Ala Pro Tyr  Arg Gln Cys 
    1010                 1015                 1020             


Tyr Gln  Glu Val Cys Asn Asp  Arg Ile Asn Ala Asn  Thr Ile Thr 
    1025                 1030                 1035             


Ser Pro  Arg Leu Ala Ala Leu  Thr Tyr Lys Cys Thr  Arg Asp Gln 
    1040                 1045                 1050             


Trp Thr  Val Tyr Cys Arg Val  Ile Arg Glu Lys Asn  Leu Cys Gln 
    1055                 1060                 1065             


Asp Met  Arg Trp Tyr Gln Arg  Cys Cys Gln Thr Cys  Arg Asp Phe 
    1070                 1075                 1080             


Tyr Ala  Asn Lys Met Arg Gln  Pro Pro Pro Asn Ser  
    1085                 1090                 1095 


<210>  214
<211>  1221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS18__Homo_sapiens__NP_955387

<400>  214

Met Glu Cys Ala Leu Leu Leu Ala Cys Ala Phe Pro Ala Ala Gly Ser 
1               5                   10                  15      


Gly Pro Pro Arg Gly Leu Ala Gly Leu Gly Arg Val Ala Lys Ala Leu 
            20                  25                  30          


Gln Leu Cys Cys Leu Cys Cys Ala Ser Val Ala Ala Ala Leu Ala Ser 
        35                  40                  45              


Asp Ser Ser Ser Gly Ala Ser Gly Leu Asn Asp Asp Tyr Val Phe Val 
    50                  55                  60                  


Thr Pro Val Glu Val Asp Ser Ala Gly Ser Tyr Ile Ser His Asp Ile 
65                  70                  75                  80  


Leu His Asn Gly Arg Lys Lys Arg Ser Ala Gln Asn Ala Arg Ser Ser 
                85                  90                  95      


Leu His Tyr Arg Phe Ser Ala Phe Gly Gln Glu Leu His Leu Glu Leu 
            100                 105                 110         


Lys Pro Ser Ala Ile Leu Ser Ser His Phe Ile Val Gln Val Leu Gly 
        115                 120                 125             


Lys Asp Gly Ala Ser Glu Thr Gln Lys Pro Glu Val Gln Gln Cys Phe 
    130                 135                 140                 


Tyr Gln Gly Phe Ile Arg Asn Asp Ser Ser Ser Ser Val Ala Val Ser 
145                 150                 155                 160 


Thr Cys Ala Gly Leu Ser Gly Leu Ile Arg Thr Arg Lys Asn Glu Phe 
                165                 170                 175     


Leu Ile Ser Pro Leu Pro Gln Leu Leu Ala Gln Glu His Asn Tyr Ser 
            180                 185                 190         


Ser Pro Ala Gly His His Pro His Val Leu Tyr Lys Arg Thr Ala Glu 
        195                 200                 205             


Glu Lys Ile Gln Arg Tyr Arg Gly Tyr Pro Gly Ser Gly Arg Asn Tyr 
    210                 215                 220                 


Pro Gly Tyr Ser Pro Ser His Ile Pro His Ala Ser Gln Ser Arg Glu 
225                 230                 235                 240 


Thr Glu Tyr His His Arg Arg Leu Gln Lys Gln His Phe Cys Gly Arg 
                245                 250                 255     


Arg Lys Lys Tyr Ala Pro Lys Pro Pro Thr Glu Asp Thr Tyr Leu Arg 
            260                 265                 270         


Phe Asp Glu Tyr Gly Ser Ser Gly Arg Pro Arg Arg Ser Ala Gly Lys 
        275                 280                 285             


Ser Gln Lys Gly Leu Asn Val Glu Thr Leu Val Val Ala Asp Lys Lys 
    290                 295                 300                 


Met Val Glu Lys His Gly Lys Gly Asn Val Thr Thr Tyr Ile Leu Thr 
305                 310                 315                 320 


Val Met Asn Met Val Ser Gly Leu Phe Lys Asp Gly Thr Ile Gly Ser 
                325                 330                 335     


Asp Ile Asn Val Val Val Val Ser Leu Ile Leu Leu Glu Gln Glu Pro 
            340                 345                 350         


Gly Gly Leu Leu Ile Asn His His Ala Asp Gln Ser Leu Asn Ser Phe 
        355                 360                 365             


Cys Gln Trp Gln Ser Ala Leu Ile Gly Lys Asn Gly Lys Arg His Asp 
    370                 375                 380                 


His Ala Ile Leu Leu Thr Gly Phe Asp Ile Cys Ser Trp Lys Asn Glu 
385                 390                 395                 400 


Pro Cys Asp Thr Leu Gly Phe Ala Pro Ile Ser Gly Met Cys Ser Lys 
                405                 410                 415     


Tyr Arg Ser Cys Thr Ile Asn Glu Asp Thr Gly Leu Gly Leu Ala Phe 
            420                 425                 430         


Thr Ile Ala His Glu Ser Gly His Asn Phe Gly Met Ile His Asp Gly 
        435                 440                 445             


Glu Gly Asn Pro Cys Arg Lys Ala Glu Gly Asn Ile Met Ser Pro Thr 
    450                 455                 460                 


Leu Thr Gly Asn Asn Gly Val Phe Ser Trp Ser Ser Cys Ser Arg Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Leu Ser Thr Pro Gln Ala Gly Cys Leu Val Asp 
                485                 490                 495     


Glu Pro Lys Gln Ala Gly Gln Tyr Lys Tyr Pro Asp Lys Leu Pro Gly 
            500                 505                 510         


Gln Ile Tyr Asp Ala Asp Thr Gln Cys Lys Trp Gln Phe Gly Ala Lys 
        515                 520                 525             


Ala Lys Leu Cys Ser Leu Gly Phe Val Lys Asp Ile Cys Lys Ser Leu 
    530                 535                 540                 


Trp Cys His Arg Val Gly His Arg Cys Glu Thr Lys Phe Met Pro Ala 
545                 550                 555                 560 


Ala Glu Gly Thr Val Cys Gly Leu Ser Met Trp Cys Arg Gln Gly Gln 
                565                 570                 575     


Cys Val Lys Phe Gly Glu Leu Gly Pro Arg Pro Ile His Gly Gln Trp 
            580                 585                 590         


Ser Ala Trp Ser Lys Trp Ser Glu Cys Ser Arg Thr Cys Gly Gly Gly 
        595                 600                 605             


Val Lys Phe Gln Glu Arg His Cys Asn Asn Pro Lys Pro Gln Tyr Gly 
    610                 615                 620                 


Gly Leu Phe Cys Pro Gly Ser Ser Arg Ile Tyr Gln Leu Cys Asn Ile 
625                 630                 635                 640 


Asn Pro Cys Asn Glu Asn Ser Leu Asp Phe Arg Ala Gln Gln Cys Ala 
                645                 650                 655     


Glu Tyr Asn Ser Lys Pro Phe Arg Gly Trp Phe Tyr Gln Trp Lys Pro 
            660                 665                 670         


Tyr Thr Lys Val Glu Glu Glu Asp Arg Cys Lys Leu Tyr Cys Lys Ala 
        675                 680                 685             


Glu Asn Phe Glu Phe Phe Phe Ala Met Ser Gly Lys Val Lys Asp Gly 
    690                 695                 700                 


Thr Pro Cys Ser Pro Asn Lys Asn Asp Val Cys Ile Asp Gly Val Cys 
705                 710                 715                 720 


Glu Leu Val Gly Cys Asp His Glu Leu Gly Ser Lys Ala Val Ser Asp 
                725                 730                 735     


Ala Cys Gly Val Cys Lys Gly Asp Asn Ser Thr Cys Lys Phe Tyr Lys 
            740                 745                 750         


Gly Leu Tyr Leu Asn Gln His Lys Ala Asn Glu Tyr Tyr Pro Val Val 
        755                 760                 765             


Leu Ile Pro Ala Gly Ala Arg Ser Ile Glu Ile Gln Glu Leu Gln Val 
    770                 775                 780                 


Ser Ser Ser Tyr Leu Ala Val Arg Ser Leu Ser Gln Lys Tyr Tyr Leu 
785                 790                 795                 800 


Thr Gly Gly Trp Ser Ile Asp Trp Pro Gly Glu Phe Pro Phe Ala Gly 
                805                 810                 815     


Thr Thr Phe Glu Tyr Gln Arg Ser Phe Asn Arg Pro Glu Arg Leu Tyr 
            820                 825                 830         


Ala Pro Gly Pro Thr Asn Glu Thr Leu Val Phe Glu Ile Leu Met Gln 
        835                 840                 845             


Gly Lys Asn Pro Gly Ile Ala Trp Lys Tyr Ala Leu Pro Lys Val Met 
    850                 855                 860                 


Asn Gly Thr Pro Pro Ala Thr Lys Arg Pro Ala Tyr Thr Trp Ser Ile 
865                 870                 875                 880 


Val Gln Ser Glu Cys Ser Val Ser Cys Gly Gly Gly Tyr Ile Asn Val 
                885                 890                 895     


Lys Ala Ile Cys Leu Arg Asp Gln Asn Thr Gln Val Asn Ser Ser Phe 
            900                 905                 910         


Cys Ser Ala Lys Thr Lys Pro Val Thr Glu Pro Lys Ile Cys Asn Ala 
        915                 920                 925             


Phe Ser Cys Pro Ala Tyr Trp Met Pro Gly Glu Trp Ser Thr Cys Ser 
    930                 935                 940                 


Lys Ala Cys Ala Gly Gly Gln Gln Ser Arg Lys Ile Gln Cys Val Gln 
945                 950                 955                 960 


Lys Lys Pro Phe Gln Lys Glu Glu Ala Val Leu His Ser Leu Cys Pro 
                965                 970                 975     


Val Ser Thr Pro Thr Gln Val Gln Ala Cys Asn Ser His Ala Cys Pro 
            980                 985                 990         


Pro Gln Trp Ser Leu Gly Pro Trp  Ser Gln Cys Ser Lys  Thr Cys Gly 
        995                 1000                 1005             


Arg Gly  Val Arg Lys Arg Glu  Leu Leu Cys Lys Gly  Ser Ala Ala 
    1010                 1015                 1020             


Glu Thr  Leu Pro Glu Ser Gln  Cys Thr Ser Leu Pro  Arg Pro Glu 
    1025                 1030                 1035             


Leu Gln  Glu Gly Cys Val Leu  Gly Arg Cys Pro Lys  Asn Ser Arg 
    1040                 1045                 1050             


Leu Gln  Trp Val Ala Ser Ser  Trp Ser Glu Cys Ser  Ala Thr Cys 
    1055                 1060                 1065             


Gly Leu  Gly Val Arg Lys Arg  Glu Met Lys Cys Ser  Glu Lys Gly 
    1070                 1075                 1080             


Phe Gln  Gly Lys Leu Ile Thr  Phe Pro Glu Arg Arg  Cys Arg Asn 
    1085                 1090                 1095             


Ile Lys  Lys Pro Asn Leu Asp  Leu Glu Glu Thr Cys  Asn Arg Arg 
    1100                 1105                 1110             


Ala Cys  Pro Ala His Pro Val  Tyr Asn Met Val Ala  Gly Trp Tyr 
    1115                 1120                 1125             


Ser Leu  Pro Trp Gln Gln Cys  Thr Val Thr Cys Gly  Gly Gly Val 
    1130                 1135                 1140             


Gln Thr  Arg Ser Val His Cys  Val Gln Gln Gly Arg  Pro Ser Ser 
    1145                 1150                 1155             


Ser Cys  Leu Leu His Gln Lys  Pro Pro Val Leu Arg  Ala Cys Asn 
    1160                 1165                 1170             


Thr Asn  Phe Cys Pro Ala Pro  Glu Lys Arg Glu Asp  Pro Ser Cys 
    1175                 1180                 1185             


Val Asp  Phe Phe Asn Trp Cys  His Leu Val Pro Gln  His Gly Val 
    1190                 1195                 1200             


Cys Asn  His Lys Phe Tyr Gly  Lys Gln Cys Cys Lys  Ser Cys Thr 
    1205                 1210                 1215             


Arg Lys  Ile 
    1220     


<210>  215
<211>  1207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS19__Homo_sapiens__NP_598377

<400>  215

Met Arg Leu Thr His Ile Cys Cys Cys Cys Leu Leu Tyr Gln Leu Gly 
1               5                   10                  15      


Phe Leu Ser Asn Gly Ile Val Ser Glu Leu Gln Phe Ala Pro Asp Arg 
            20                  25                  30          


Glu Glu Trp Glu Val Val Phe Pro Ala Leu Trp Arg Arg Glu Pro Val 
        35                  40                  45              


Asp Pro Ala Gly Gly Ser Gly Gly Ser Ala Asp Pro Gly Trp Val Arg 
    50                  55                  60                  


Gly Val Gly Gly Gly Gly Ser Ala Arg Ala Gln Ala Ala Gly Ser Ser 
65                  70                  75                  80  


Arg Glu Val Arg Ser Val Ala Pro Val Pro Leu Glu Glu Pro Val Glu 
                85                  90                  95      


Gly Arg Ser Glu Ser Arg Leu Arg Pro Pro Pro Pro Ser Glu Gly Glu 
            100                 105                 110         


Glu Asp Glu Glu Leu Glu Ser Gln Glu Leu Pro Arg Gly Ser Ser Gly 
        115                 120                 125             


Ala Ala Ala Leu Ser Pro Gly Ala Pro Ala Ser Trp Gln Pro Pro Pro 
    130                 135                 140                 


Pro Pro Gln Pro Pro Pro Ser Pro Pro Pro Ala Gln His Ala Glu Pro 
145                 150                 155                 160 


Asp Gly Asp Glu Val Leu Leu Arg Ile Pro Ala Phe Ser Arg Asp Leu 
                165                 170                 175     


Tyr Leu Leu Leu Arg Arg Asp Gly Arg Phe Leu Ala Pro Arg Phe Ala 
            180                 185                 190         


Val Glu Gln Arg Pro Asn Pro Gly Pro Gly Pro Thr Gly Ala Ala Ser 
        195                 200                 205             


Ala Pro Gln Pro Pro Ala Pro Pro Asp Ala Gly Cys Phe Tyr Thr Gly 
    210                 215                 220                 


Ala Val Leu Arg His Pro Gly Ser Leu Ala Ser Phe Ser Thr Cys Gly 
225                 230                 235                 240 


Gly Gly Leu Met Gly Phe Ile Gln Leu Asn Glu Asp Phe Ile Phe Ile 
                245                 250                 255     


Glu Pro Leu Asn Asp Thr Met Ala Ile Thr Gly His Pro His Arg Val 
            260                 265                 270         


Tyr Arg Gln Lys Arg Ser Met Glu Glu Lys Val Thr Glu Lys Ser Ala 
        275                 280                 285             


Leu His Ser His Tyr Cys Gly Ile Ile Ser Asp Lys Gly Arg Pro Arg 
    290                 295                 300                 


Ser Arg Lys Ile Ala Glu Ser Gly Arg Gly Lys Arg Tyr Ser Tyr Lys 
305                 310                 315                 320 


Leu Pro Gln Glu Tyr Asn Ile Glu Thr Val Val Val Ala Asp Pro Ala 
                325                 330                 335     


Met Val Ser Tyr His Gly Ala Asp Ala Ala Arg Arg Phe Ile Leu Thr 
            340                 345                 350         


Ile Leu Asn Met Val Phe Asn Leu Phe Gln His Lys Ser Leu Ser Val 
        355                 360                 365             


Gln Val Asn Leu Arg Val Ile Lys Leu Ile Leu Leu His Glu Thr Pro 
    370                 375                 380                 


Pro Glu Leu Tyr Ile Gly His His Gly Glu Lys Met Leu Glu Ser Phe 
385                 390                 395                 400 


Cys Lys Trp Gln His Glu Glu Phe Gly Lys Lys Asn Asp Ile His Leu 
                405                 410                 415     


Glu Met Ser Thr Asn Trp Gly Glu Asp Met Thr Ser Val Asp Ala Ala 
            420                 425                 430         


Ile Leu Ile Thr Arg Lys Asp Phe Cys Val His Lys Asp Glu Pro Cys 
        435                 440                 445             


Asp Thr Val Gly Ile Ala Tyr Leu Ser Gly Met Cys Ser Glu Lys Arg 
    450                 455                 460                 


Lys Cys Ile Ile Ala Glu Asp Asn Gly Leu Asn Leu Ala Phe Thr Ile 
465                 470                 475                 480 


Ala His Glu Met Gly His Asn Met Gly Ile Asn His Asp Asn Asp His 
                485                 490                 495     


Pro Ser Cys Ala Asp Gly Leu His Ile Met Ser Gly Glu Trp Ile Lys 
            500                 505                 510         


Gly Gln Asn Leu Gly Asp Val Ser Trp Ser Arg Cys Ser Lys Glu Asp 
        515                 520                 525             


Leu Glu Arg Phe Leu Arg Ser Lys Ala Ser Asn Cys Leu Leu Gln Thr 
    530                 535                 540                 


Asn Pro Gln Ser Val Asn Ser Val Met Val Pro Ser Lys Leu Pro Gly 
545                 550                 555                 560 


Met Thr Tyr Thr Ala Asp Glu Gln Cys Gln Ile Leu Phe Gly Pro Leu 
                565                 570                 575     


Ala Ser Phe Cys Gln Glu Met Gln His Val Ile Cys Thr Gly Leu Trp 
            580                 585                 590         


Cys Lys Val Glu Gly Glu Lys Glu Cys Arg Thr Lys Leu Asp Pro Pro 
        595                 600                 605             


Met Asp Gly Thr Asp Cys Asp Leu Gly Lys Trp Cys Lys Ala Gly Glu 
    610                 615                 620                 


Cys Thr Ser Arg Thr Ser Ala Pro Glu His Leu Ala Gly Glu Trp Ser 
625                 630                 635                 640 


Leu Trp Ser Pro Cys Ser Arg Thr Cys Ser Ala Gly Ile Ser Ser Arg 
                645                 650                 655     


Glu Arg Lys Cys Pro Gly Leu Asp Ser Glu Ala Arg Asp Cys Asn Gly 
            660                 665                 670         


Pro Arg Lys Gln Tyr Arg Ile Cys Glu Asn Pro Pro Cys Pro Ala Gly 
        675                 680                 685             


Leu Pro Gly Phe Arg Asp Trp Gln Cys Gln Ala Tyr Ser Val Arg Thr 
    690                 695                 700                 


Ser Ser Pro Lys His Ile Leu Gln Trp Gln Ala Val Leu Asp Glu Glu 
705                 710                 715                 720 


Lys Pro Cys Ala Leu Phe Cys Ser Pro Val Gly Lys Glu Gln Pro Ile 
                725                 730                 735     


Leu Leu Ser Glu Lys Val Met Asp Gly Thr Ser Cys Gly Tyr Gln Gly 
            740                 745                 750         


Leu Asp Ile Cys Ala Asn Gly Arg Cys Gln Lys Val Gly Cys Asp Gly 
        755                 760                 765             


Leu Leu Gly Ser Leu Ala Arg Glu Asp His Cys Gly Val Cys Asn Gly 
    770                 775                 780                 


Asn Gly Lys Ser Cys Lys Ile Ile Lys Gly Asp Phe Asn His Thr Arg 
785                 790                 795                 800 


Gly Ala Gly Tyr Val Glu Val Leu Val Ile Pro Ala Gly Ala Arg Arg 
                805                 810                 815     


Ile Lys Val Val Glu Glu Lys Pro Ala His Ser Tyr Leu Ala Leu Arg 
            820                 825                 830         


Asp Ala Gly Lys Gln Ser Ile Asn Ser Asp Trp Lys Ile Glu His Ser 
        835                 840                 845             


Gly Ala Phe Asn Leu Ala Gly Thr Thr Val His Tyr Val Arg Arg Gly 
    850                 855                 860                 


Leu Trp Glu Lys Ile Ser Ala Lys Gly Pro Thr Thr Ala Pro Leu His 
865                 870                 875                 880 


Leu Leu Val Leu Leu Phe Gln Asp Gln Asn Tyr Gly Leu His Tyr Glu 
                885                 890                 895     


Tyr Thr Ile Pro Ser Asp Pro Leu Pro Glu Asn Gln Ser Ser Lys Ala 
            900                 905                 910         


Pro Glu Pro Leu Phe Met Trp Thr His Thr Ser Trp Glu Asp Cys Asp 
        915                 920                 925             


Ala Thr Cys Gly Gly Gly Glu Arg Lys Thr Thr Val Ser Cys Thr Lys 
    930                 935                 940                 


Ile Met Ser Lys Asn Ile Ser Ile Val Asp Asn Glu Lys Cys Lys Tyr 
945                 950                 955                 960 


Leu Thr Lys Pro Glu Pro Gln Ile Arg Lys Cys Asn Glu Gln Pro Cys 
                965                 970                 975     


Gln Thr Arg Trp Met Met Thr Glu Trp Thr Pro Cys Ser Arg Thr Cys 
            980                 985                 990         


Gly Lys Gly Met Gln Ser Arg Gln  Val Ala Cys Thr Gln  Gln Leu Ser 
        995                 1000                 1005             


Asn Gly  Thr Leu Ile Arg Ala  Arg Glu Arg Asp Cys  Ile Gly Pro 
    1010                 1015                 1020             


Lys Pro  Ala Ser Ala Gln Arg  Cys Glu Gly Gln Asp  Cys Met Thr 
    1025                 1030                 1035             


Val Trp  Glu Ala Gly Val Trp  Ser Glu Cys Ser Val  Lys Cys Gly 
    1040                 1045                 1050             


Lys Gly  Ile Arg His Arg Thr  Val Arg Cys Thr Asn  Pro Arg Lys 
    1055                 1060                 1065             


Lys Cys  Val Leu Ser Thr Arg  Pro Arg Glu Ala Glu  Asp Cys Glu 
    1070                 1075                 1080             


Asp Tyr  Ser Lys Cys Tyr Val  Trp Arg Met Gly Asp  Trp Ser Lys 
    1085                 1090                 1095             


Cys Ser  Ile Thr Cys Gly Lys  Gly Met Gln Ser Arg  Val Ile Gln 
    1100                 1105                 1110             


Cys Met  His Lys Ile Thr Gly  Arg His Gly Asn Glu  Cys Phe Ser 
    1115                 1120                 1125             


Ser Glu  Lys Pro Ala Ala Tyr  Arg Pro Cys His Leu  Gln Pro Cys 
    1130                 1135                 1140             


Asn Glu  Lys Ile Asn Val Asn  Thr Ile Thr Ser Pro  Arg Leu Ala 
    1145                 1150                 1155             


Ala Leu  Thr Phe Lys Cys Leu  Gly Asp Gln Trp Pro  Val Tyr Cys 
    1160                 1165                 1170             


Arg Val  Ile Arg Glu Lys Asn  Leu Cys Gln Asp Met  Arg Trp Tyr 
    1175                 1180                 1185             


Gln Arg  Cys Cys Glu Thr Cys  Arg Asp Phe Tyr Ala  Gln Lys Leu 
    1190                 1195                 1200             


Gln Gln  Lys Ser 
    1205         


<210>  216
<211>  967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS1__Homo_sapiens__NP_008919

<400>  216

Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser 
1               5                   10                  15      


Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro 
            20                  25                  30          


Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp 
        35                  40                  45              


Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu 
    50                  55                  60                  


Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala 
65                  70                  75                  80  


Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu 
                85                  90                  95      


Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu 
            100                 105                 110         


Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr 
        115                 120                 125             


Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly 
    130                 135                 140                 


Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro 
145                 150                 155                 160 


Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys 
                165                 170                 175     


Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly 
            180                 185                 190         


Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr 
        195                 200                 205             


Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Gly Glu Asp 
    210                 215                 220                 


Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly 
225                 230                 235                 240 


Gln Pro Thr Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser 
                245                 250                 255     


His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met Ala Glu 
            260                 265                 270         


Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe Ser Val 
        275                 280                 285             


Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu 
    290                 295                 300                 


Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu 
305                 310                 315                 320 


Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln 
                325                 330                 335     


Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Thr 
            340                 345                 350         


Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp 
        355                 360                 365             


Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser Arg Ser 
    370                 375                 380                 


Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala 
385                 390                 395                 400 


His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln 
                405                 410                 415     


Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser 
            420                 425                 430         


Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala 
        435                 440                 445             


Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met 
    450                 455                 460                 


Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Thr 
465                 470                 475                 480 


Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe Gly Glu Asp Ser 
                485                 490                 495     


Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr Leu Trp Cys Thr 
            500                 505                 510         


Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys His Phe Pro Trp 
        515                 520                 525             


Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys 
    530                 535                 540                 


Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr Pro Phe His Gly 
545                 550                 555                 560 


Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly 
                565                 570                 575     


Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn Pro Val Pro Lys 
            580                 585                 590         


Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys 
        595                 600                 605             


Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr Phe Arg Glu Glu 
    610                 615                 620                 


Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly 
625                 630                 635                 640 


Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp 
                645                 650                 655     


Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val 
            660                 665                 670         


Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser Pro Asp Ser Thr 
        675                 680                 685             


Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile 
    690                 695                 700                 


Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn 
705                 710                 715                 720 


Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr Ser Ala Lys Pro 
                725                 730                 735     


Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala Thr Asn Ile Glu 
            740                 745                 750         


Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu 
        755                 760                 765             


Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn Gly Asp Tyr Thr 
    770                 775                 780                 


Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg 
785                 790                 795                 800 


Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro 
                805                 810                 815     


Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val Gly Asn Ala Leu 
            820                 825                 830         


Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys Lys Lys Glu Ser 
        835                 840                 845             


Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile Glu Glu Trp Gly 
    850                 855                 860                 


Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu 
865                 870                 875                 880 


Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val 
                885                 890                 895     


Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp 
            900                 905                 910         


Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys Gly Lys Gly Tyr 
        915                 920                 925             


Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser 
    930                 935                 940                 


His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe 
945                 950                 955                 960 


Cys Thr Met Ala Glu Cys Ser 
                965         


<210>  217
<211>  1910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS20__Homo_sapiens__NP_079279

<400>  217

Met Trp Val Ala Lys Trp Leu Thr Gly Leu Leu Tyr His Leu Ser Leu 
1               5                   10                  15      


Phe Ile Thr Arg Ser Trp Glu Val Asp Phe His Pro Arg Gln Glu Ala 
            20                  25                  30          


Leu Val Arg Thr Leu Thr Ser Tyr Glu Val Val Ile Pro Glu Arg Val 
        35                  40                  45              


Asn Glu Phe Gly Glu Val Phe Pro Gln Ser His His Phe Ser Arg Gln 
    50                  55                  60                  


Lys Arg Ser Ser Glu Ala Leu Glu Pro Met Pro Phe Arg Thr His Tyr 
65                  70                  75                  80  


Arg Phe Thr Ala Tyr Gly Gln Leu Phe Gln Leu Asn Leu Thr Ala Asp 
                85                  90                  95      


Ala Ser Phe Leu Ala Ala Gly Tyr Thr Glu Val His Leu Gly Thr Pro 
            100                 105                 110         


Glu Arg Gly Ala Trp Glu Ser Asp Ala Gly Pro Ser Asp Leu Arg His 
        115                 120                 125             


Cys Phe Tyr Arg Gly Gln Val Asn Ser Gln Glu Asp Tyr Lys Ala Val 
    130                 135                 140                 


Val Ser Leu Cys Gly Gly Leu Thr Gly Thr Phe Lys Gly Gln Asn Gly 
145                 150                 155                 160 


Glu Tyr Phe Leu Glu Pro Ile Met Lys Ala Asp Gly Asn Glu Tyr Glu 
                165                 170                 175     


Asp Gly His Asn Lys Pro His Leu Ile Tyr Arg Gln Asp Leu Asn Asn 
            180                 185                 190         


Ser Phe Leu Gln Thr Leu Lys Tyr Cys Ser Val Ser Glu Ser Gln Ile 
        195                 200                 205             


Lys Glu Thr Ser Leu Pro Phe His Thr Tyr Ser Asn Met Asn Glu Asp 
    210                 215                 220                 


Leu Asn Val Met Lys Glu Arg Val Leu Gly His Thr Ser Lys Asn Val 
225                 230                 235                 240 


Pro Leu Lys Asp Glu Arg Arg His Ser Arg Lys Lys Arg Leu Ile Ser 
                245                 250                 255     


Tyr Pro Arg Tyr Ile Glu Ile Met Val Thr Ala Asp Ala Lys Val Val 
            260                 265                 270         


Ser Ala His Gly Ser Asn Leu Gln Asn Tyr Ile Leu Thr Leu Met Ser 
        275                 280                 285             


Ile Val Ala Thr Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu Ile His 
    290                 295                 300                 


Ile Val Val Val Lys Leu Val Met Ile His Arg Glu Glu Glu Gly Pro 
305                 310                 315                 320 


Val Ile Asn Phe Asp Gly Ala Thr Thr Leu Lys Asn Phe Cys Ser Trp 
                325                 330                 335     


Gln Gln Thr Gln Asn Asp Leu Asp Asp Val His Pro Ser His His Asp 
            340                 345                 350         


Thr Ala Val Leu Ile Thr Arg Glu Asp Ile Cys Ser Ser Lys Glu Lys 
        355                 360                 365             


Cys Asn Met Leu Gly Leu Ser Tyr Leu Gly Thr Ile Cys Asp Pro Leu 
    370                 375                 380                 


Gln Ser Cys Phe Ile Asn Glu Glu Lys Gly Leu Ile Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Leu Gly His Thr Leu Gly Val Gln His Asp Asp Asn 
                405                 410                 415     


Pro Arg Cys Lys Glu Met Lys Val Thr Lys Tyr His Val Met Ala Pro 
            420                 425                 430         


Ala Leu Ser Phe His Met Ser Pro Trp Ser Trp Ser Asn Cys Ser Arg 
        435                 440                 445             


Lys Tyr Val Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
    450                 455                 460                 


Asp Lys Pro Asp Glu Glu Ile Tyr Asn Leu Pro Ser Glu Leu Pro Gly 
465                 470                 475                 480 


Ser Arg Tyr Asp Gly Asn Lys Gln Cys Glu Leu Ala Phe Gly Pro Gly 
                485                 490                 495     


Ser Gln Met Cys Pro His Ile Asn Ile Cys Met His Leu Trp Cys Thr 
            500                 505                 510         


Ser Thr Glu Lys Leu His Lys Gly Cys Phe Thr Gln His Val Pro Pro 
        515                 520                 525             


Ala Asp Gly Thr Asp Cys Gly Pro Gly Met His Cys Arg His Gly Leu 
    530                 535                 540                 


Cys Val Asn Lys Glu Thr Glu Thr Arg Pro Val Asn Gly Glu Trp Gly 
545                 550                 555                 560 


Pro Trp Glu Pro Tyr Ser Ser Cys Ser Arg Thr Cys Gly Gly Gly Ile 
                565                 570                 575     


Glu Ser Ala Thr Arg Arg Cys Asn Arg Pro Glu Pro Arg Asn Gly Gly 
            580                 585                 590         


Asn Tyr Cys Val Gly Arg Arg Met Lys Phe Arg Ser Cys Asn Thr Asp 
        595                 600                 605             


Ser Cys Pro Lys Gly Thr Gln Asp Phe Arg Glu Lys Gln Cys Ser Asp 
    610                 615                 620                 


Phe Asn Gly Lys His Leu Asp Ile Ser Gly Ile Pro Ser Asn Val Arg 
625                 630                 635                 640 


Trp Leu Pro Arg Tyr Ser Gly Ile Gly Thr Lys Asp Arg Cys Lys Leu 
                645                 650                 655     


Tyr Cys Gln Val Ala Gly Thr Asn Tyr Phe Tyr Leu Leu Lys Asp Met 
            660                 665                 670         


Val Glu Asp Gly Thr Pro Cys Gly Thr Glu Thr His Asp Ile Cys Val 
        675                 680                 685             


Gln Gly Gln Cys Met Ala Ala Gly Cys Asp His Val Leu Asn Ser Ser 
    690                 695                 700                 


Ala Lys Ile Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
705                 710                 715                 720 


Lys Thr Ile Thr Gly Val Phe Asn Ser Ser His Tyr Gly Tyr Asn Val 
                725                 730                 735     


Val Val Lys Ile Pro Ala Gly Ala Thr Asn Val Asp Ile Arg Gln Tyr 
            740                 745                 750         


Ser Tyr Ser Gly Gln Pro Asp Asp Ser Tyr Leu Ala Leu Ser Asp Ala 
        755                 760                 765             


Glu Gly Asn Phe Leu Phe Asn Gly Asn Phe Leu Leu Ser Thr Ser Lys 
    770                 775                 780                 


Lys Glu Ile Asn Val Gln Gly Thr Arg Thr Val Ile Glu Tyr Ser Gly 
785                 790                 795                 800 


Ser Asn Asn Ala Val Glu Arg Ile Asn Ser Thr Asn Arg Gln Glu Lys 
                805                 810                 815     


Glu Leu Ile Leu Gln Val Leu Cys Val Gly Asn Leu Tyr Asn Pro Asp 
            820                 825                 830         


Val His Tyr Ser Phe Asn Ile Pro Leu Glu Glu Arg Ser Asp Met Phe 
        835                 840                 845             


Thr Trp Asp Pro Tyr Gly Pro Trp Glu Gly Cys Thr Lys Met Cys Gln 
    850                 855                 860                 


Gly Leu Gln Arg Arg Asn Ile Thr Cys Ile His Lys Ser Asp His Ser 
865                 870                 875                 880 


Val Val Ser Asp Lys Glu Cys Asp His Leu Pro Leu Pro Ser Phe Val 
                885                 890                 895     


Thr Gln Ser Cys Asn Thr Asp Cys Glu Leu Arg Trp His Val Ile Gly 
            900                 905                 910         


Lys Ser Glu Cys Ser Ser Gln Cys Gly Gln Gly Tyr Arg Thr Leu Asp 
        915                 920                 925             


Ile His Cys Met Lys Tyr Ser Ile His Glu Gly Gln Thr Val Gln Val 
    930                 935                 940                 


Asp Asp His Tyr Cys Gly Asp Gln Leu Lys Pro Pro Thr Gln Glu Leu 
945                 950                 955                 960 


Cys His Gly Asn Cys Val Phe Thr Arg Trp His Tyr Ser Glu Trp Ser 
                965                 970                 975     


Gln Cys Ser Arg Ser Cys Gly Gly Gly Glu Arg Ser Arg Glu Ser Tyr 
            980                 985                 990         


Cys Met Asn Asn Phe Gly His Arg  Leu Ala Asp Asn Glu  Cys Gln Glu 
        995                 1000                 1005             


Leu Ser  Arg Val Thr Arg Glu  Asn Cys Asn Glu Phe  Ser Cys Pro 
    1010                 1015                 1020             


Ser Trp  Ala Ala Ser Glu Trp  Ser Glu Cys Leu Val  Thr Cys Gly 
    1025                 1030                 1035             


Lys Gly  Thr Lys Gln Arg Gln  Val Trp Cys Gln Leu  Asn Val Asp 
    1040                 1045                 1050             


His Leu  Ser Asp Gly Phe Cys  Asn Ser Ser Thr Lys  Pro Glu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Cys Glu Leu His  Thr Cys Ala Ser Trp  Gln Val Gly 
    1070                 1075                 1080             


Pro Trp  Gly Pro Cys Thr Thr  Thr Cys Gly His Gly  Tyr Gln Met 
    1085                 1090                 1095             


Arg Asp  Val Lys Cys Val Asn  Glu Leu Ala Ser Ala  Val Leu Glu 
    1100                 1105                 1110             


Asp Thr  Glu Cys His Glu Ala  Ser Arg Pro Ser Asp  Arg Gln Ser 
    1115                 1120                 1125             


Cys Val  Leu Thr Pro Cys Ser  Phe Ile Ser Lys Leu  Glu Thr Ala 
    1130                 1135                 1140             


Leu Leu  Pro Thr Val Leu Ile  Lys Lys Met Ala Gln  Trp Arg His 
    1145                 1150                 1155             


Gly Ser  Trp Thr Pro Cys Ser  Val Ser Cys Gly Arg  Gly Thr Gln 
    1160                 1165                 1170             


Ala Arg  Tyr Val Ser Cys Arg  Asp Ala Leu Asp Arg  Ile Ala Asp 
    1175                 1180                 1185             


Glu Ser  Tyr Cys Ala His Leu  Pro Arg Pro Ala Glu  Ile Trp Asp 
    1190                 1195                 1200             


Cys Phe  Thr Pro Cys Gly Glu  Trp Gln Ala Gly Asp  Trp Ser Pro 
    1205                 1210                 1215             


Cys Ser  Ala Ser Cys Gly His  Gly Lys Thr Thr Arg  Gln Val Leu 
    1220                 1225                 1230             


Cys Met  Asn Tyr His Gln Pro  Ile Asp Glu Asn Tyr  Cys Asp Pro 
    1235                 1240                 1245             


Glu Val  Arg Pro Leu Met Glu  Gln Glu Cys Ser Leu  Ala Ala Cys 
    1250                 1255                 1260             


Pro Pro  Ala His Ser His Phe  Pro Ser Ser Pro Val  Gln Pro Ser 
    1265                 1270                 1275             


Tyr Tyr  Leu Ser Thr Asn Leu  Pro Leu Thr Gln Lys  Leu Glu Asp 
    1280                 1285                 1290             


Asn Glu  Asn Gln Val Val His  Pro Ser Val Arg Gly  Asn Gln Trp 
    1295                 1300                 1305             


Arg Thr  Gly Pro Trp Gly Ser  Cys Ser Ser Ser Cys  Ser Gly Gly 
    1310                 1315                 1320             


Leu Gln  His Arg Ala Val Val  Cys Gln Asp Glu Asn  Gly Gln Ser 
    1325                 1330                 1335             


Ala Ser  Tyr Cys Asp Ala Ala  Ser Lys Pro Pro Glu  Leu Gln Gln 
    1340                 1345                 1350             


Cys Gly  Pro Gly Pro Cys Pro  Gln Trp Asn Tyr Gly  Asn Trp Gly 
    1355                 1360                 1365             


Glu Cys  Ser Gln Thr Cys Gly  Gly Gly Ile Lys Ser  Arg Leu Val 
    1370                 1375                 1380             


Ile Cys  Gln Phe Pro Asn Gly  Gln Ile Leu Glu Asp  His Asn Cys 
    1385                 1390                 1395             


Glu Ile  Val Asn Lys Pro Pro  Ser Val Ile Gln Cys  His Met His 
    1400                 1405                 1410             


Ala Cys  Pro Ala Asp Val Ser  Trp His Gln Glu Pro  Trp Thr Ser 
    1415                 1420                 1425             


Cys Ser  Ala Ser Cys Gly Lys  Gly Arg Lys Tyr Arg  Glu Val Phe 
    1430                 1435                 1440             


Cys Ile  Asp Gln Phe Gln Arg  Lys Leu Glu Asp Thr  Asn Cys Ser 
    1445                 1450                 1455             


Gln Val  Gln Lys Pro Pro Thr  His Lys Ala Cys Arg  Ser Val Arg 
    1460                 1465                 1470             


Cys Pro  Ser Trp Lys Ala Asn  Ser Trp Asn Glu Cys  Ser Val Thr 
    1475                 1480                 1485             


Cys Gly  Ser Gly Val Gln Gln  Arg Asp Val Tyr Cys  Arg Leu Lys 
    1490                 1495                 1500             


Gly Val  Gly Gln Val Val Glu  Glu Met Cys Asp Gln  Ser Thr Arg 
    1505                 1510                 1515             


Pro Cys  Ser Gln Arg Arg Cys  Trp Ser Gln Asp Cys  Val Gln His 
    1520                 1525                 1530             


Lys Gly  Met Glu Arg Gly Arg  Leu Asn Cys Ser Thr  Ser Cys Glu 
    1535                 1540                 1545             


Arg Lys  Asp Ser His Gln Arg  Met Glu Cys Thr Asp  Asn Gln Ile 
    1550                 1555                 1560             


Arg Gln  Val Asn Glu Ile Val  Tyr Asn Ser Ser Thr  Ile Ser Leu 
    1565                 1570                 1575             


Thr Ser  Lys Asn Cys Arg Asn  Pro Pro Cys Asn Tyr  Ile Val Val 
    1580                 1585                 1590             


Thr Ala  Asp Ser Ser Gln Cys  Ala Asn Asn Cys Gly  Phe Ser Tyr 
    1595                 1600                 1605             


Arg Gln  Arg Ile Thr Tyr Cys  Thr Glu Ile Pro Ser  Thr Lys Lys 
    1610                 1615                 1620             


His Lys  Leu His Arg Leu Arg  Pro Ile Val Tyr Gln  Glu Cys Pro 
    1625                 1630                 1635             


Val Val  Pro Ser Ser Gln Val  Tyr Gln Cys Ile Asn  Ser Cys Leu 
    1640                 1645                 1650             


His Leu  Ala Thr Trp Lys Val  Gly Lys Trp Ser Lys  Cys Ser Val 
    1655                 1660                 1665             


Thr Cys  Gly Ile Gly Ile Met  Lys Arg Gln Val Lys  Cys Ile Thr 
    1670                 1675                 1680             


Lys His  Gly Leu Ser Ser Asp  Leu Cys Leu Asn His  Leu Lys Pro 
    1685                 1690                 1695             


Gly Ala  Gln Lys Lys Cys Tyr  Ala Asn Asp Cys Lys  Ser Phe Thr 
    1700                 1705                 1710             


Thr Cys  Lys Glu Ile Gln Val  Lys Asn His Ile Arg  Lys Asp Gly 
    1715                 1720                 1725             


Asp Tyr  Tyr Leu Asn Ile Lys  Gly Arg Ile Ile Lys  Ile Tyr Cys 
    1730                 1735                 1740             


Ala Asp  Met Tyr Leu Glu Asn  Pro Lys Glu Tyr Leu  Thr Leu Val 
    1745                 1750                 1755             


Gln Gly  Glu Glu Asn Phe Ser  Glu Val Tyr Gly Phe  Arg Leu Lys 
    1760                 1765                 1770             


Asn Pro  Tyr Gln Cys Pro Phe  Asn Gly Ser Arg Arg  Glu Asp Cys 
    1775                 1780                 1785             


Glu Cys  Asp Asn Gly His Leu  Ala Ala Gly Tyr Thr  Val Phe Ser 
    1790                 1795                 1800             


Lys Ile  Arg Ile Asp Leu Thr  Ser Met Gln Ile Lys  Thr Thr Asp 
    1805                 1810                 1815             


Leu Leu  Phe Ser Lys Thr Ile  Phe Gly Asn Ala Val  Pro Phe Ala 
    1820                 1825                 1830             


Thr Ala  Gly Asp Cys Tyr Ser  Ala Phe Arg Cys Pro  Gln Gly Gln 
    1835                 1840                 1845             


Phe Ser  Ile Asn Leu Ser Gly  Thr Gly Met Lys Ile  Ser Ser Thr 
    1850                 1855                 1860             


Ala Lys  Trp Leu Thr Gln Gly  Ser Tyr Thr Ser Val  Ser Ile Arg 
    1865                 1870                 1875             


Arg Ser  Glu Asp Gly Thr Arg  Phe Phe Gly Lys Cys  Gly Gly Tyr 
    1880                 1885                 1890             


Cys Gly  Lys Cys Leu Pro His  Met Thr Thr Gly Leu  Pro Ile Gln 
    1895                 1900                 1905             


Val Ile  
    1910 


<210>  218
<211>  1211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS2__Homo_sapiens__NP_055059

<400>  218

Met Asp Pro Pro Ala Gly Ala Ala Arg Arg Leu Leu Cys Pro Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Ala Asn Ala Arg Leu Ala Ala Ala Ala Asp Pro Pro Gly Gly 
        35                  40                  45              


Pro Leu Gly His Gly Ala Glu Arg Ile Leu Ala Val Pro Val Arg Thr 
    50                  55                  60                  


Asp Ala Gln Gly Arg Leu Val Ser His Val Val Ser Ala Ala Thr Ser 
65                  70                  75                  80  


Arg Ala Gly Val Arg Ala Arg Arg Ala Ala Pro Val Arg Thr Pro Ser 
                85                  90                  95      


Phe Pro Gly Gly Asn Glu Glu Glu Pro Gly Ser His Leu Phe Tyr Asn 
            100                 105                 110         


Val Thr Val Phe Gly Arg Asp Leu His Leu Arg Leu Arg Pro Asn Ala 
        115                 120                 125             


Arg Leu Val Ala Pro Gly Ala Thr Met Glu Trp Gln Gly Glu Lys Gly 
    130                 135                 140                 


Thr Thr Arg Val Glu Pro Leu Leu Gly Ser Cys Leu Tyr Val Gly Asp 
145                 150                 155                 160 


Val Ala Gly Leu Ala Glu Ala Ser Ser Val Ala Leu Ser Asn Cys Asp 
                165                 170                 175     


Gly Leu Ala Gly Leu Ile Arg Met Glu Glu Glu Glu Phe Phe Ile Glu 
            180                 185                 190         


Pro Leu Glu Lys Gly Leu Ala Ala Gln Glu Ala Glu Gln Gly Arg Val 
        195                 200                 205             


His Val Val Tyr Arg Arg Pro Pro Thr Ser Pro Pro Leu Gly Gly Pro 
    210                 215                 220                 


Gln Ala Leu Asp Thr Gly Ala Ser Leu Asp Ser Leu Asp Ser Leu Ser 
225                 230                 235                 240 


Arg Ala Leu Gly Val Leu Glu Glu His Ala Asn Ser Ser Arg Arg Arg 
                245                 250                 255     


Ala Arg Arg His Ala Ala Asp Asp Asp Tyr Asn Ile Glu Val Leu Leu 
            260                 265                 270         


Gly Val Asp Asp Ser Val Val Gln Phe His Gly Lys Glu His Val Gln 
        275                 280                 285             


Lys Tyr Leu Leu Thr Leu Met Asn Ile Val Asn Glu Ile Tyr His Asp 
    290                 295                 300                 


Glu Ser Leu Gly Ala His Ile Asn Val Val Leu Val Arg Ile Ile Leu 
305                 310                 315                 320 


Leu Ser Tyr Gly Lys Ser Met Ser Leu Ile Glu Ile Gly Asn Pro Ser 
                325                 330                 335     


Gln Ser Leu Glu Asn Val Cys Arg Trp Ala Tyr Leu Gln Gln Lys Pro 
            340                 345                 350         


Asp Thr Gly His Asp Glu Tyr His Asp His Ala Ile Phe Leu Thr Arg 
        355                 360                 365             


Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro Val Thr Gly 
    370                 375                 380                 


Met Cys His Pro Val Arg Ser Cys Thr Leu Asn His Glu Asp Gly Phe 
385                 390                 395                 400 


Ser Ser Ala Phe Val Val Ala His Glu Thr Gly His Val Leu Gly Met 
                405                 410                 415     


Glu His Asp Gly Gln Gly Asn Arg Cys Gly Asp Glu Val Arg Leu Gly 
            420                 425                 430         


Ser Ile Met Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe His Trp 
        435                 440                 445             


Ser Arg Cys Ser Gln Gln Glu Leu Ser Arg Tyr Leu His Ser Tyr Asp 
    450                 455                 460                 


Cys Leu Leu Asp Asp Pro Phe Ala His Asp Trp Pro Ala Leu Pro Gln 
465                 470                 475                 480 


Leu Pro Gly Leu His Tyr Ser Met Asn Glu Gln Cys Arg Phe Asp Phe 
                485                 490                 495     


Gly Leu Gly Tyr Met Met Cys Thr Ala Phe Arg Thr Phe Asp Pro Cys 
            500                 505                 510         


Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys Lys Thr 
        515                 520                 525             


Lys Lys Gly Pro Pro Leu Asp Gly Thr Met Cys Ala Pro Gly Lys His 
    530                 535                 540                 


Cys Phe Lys Gly His Cys Ile Trp Leu Thr Pro Asp Ile Leu Lys Arg 
545                 550                 555                 560 


Asp Gly Ser Trp Gly Ala Trp Ser Pro Phe Gly Ser Cys Ser Arg Thr 
                565                 570                 575     


Cys Gly Thr Gly Val Lys Phe Arg Thr Arg Gln Cys Asp Asn Pro His 
            580                 585                 590         


Pro Ala Asn Gly Gly Arg Thr Cys Ser Gly Leu Ala Tyr Asp Phe Gln 
        595                 600                 605             


Leu Cys Ser Arg Gln Asp Cys Pro Asp Ser Leu Ala Asp Phe Arg Glu 
    610                 615                 620                 


Glu Gln Cys Arg Gln Trp Asp Leu Tyr Phe Glu His Gly Asp Ala Gln 
625                 630                 635                 640 


His His Trp Leu Pro His Glu His Arg Asp Ala Lys Glu Arg Cys His 
                645                 650                 655     


Leu Tyr Cys Glu Ser Arg Glu Thr Gly Glu Val Val Ser Met Lys Arg 
            660                 665                 670         


Met Val His Asp Gly Thr Arg Cys Ser Tyr Lys Asp Ala Phe Ser Leu 
        675                 680                 685             


Cys Val Arg Gly Asp Cys Arg Lys Val Gly Cys Asp Gly Val Ile Gly 
    690                 695                 700                 


Ser Ser Lys Gln Glu Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser 
705                 710                 715                 720 


His Cys Lys Val Val Lys Gly Thr Phe Thr Arg Ser Pro Lys Lys His 
                725                 730                 735     


Gly Tyr Ile Lys Met Phe Glu Ile Pro Ala Gly Ala Arg His Leu Leu 
            740                 745                 750         


Ile Gln Glu Val Asp Ala Thr Ser His His Leu Ala Val Lys Asn Leu 
        755                 760                 765             


Glu Thr Gly Lys Phe Ile Leu Asn Glu Glu Asn Asp Val Asp Ala Ser 
    770                 775                 780                 


Ser Lys Thr Phe Ile Ala Met Gly Val Glu Trp Glu Tyr Arg Asp Glu 
785                 790                 795                 800 


Asp Gly Arg Glu Thr Leu Gln Thr Met Gly Pro Leu His Gly Thr Ile 
                805                 810                 815     


Thr Val Leu Val Ile Pro Val Gly Asp Thr Arg Val Ser Leu Thr Tyr 
            820                 825                 830         


Lys Tyr Met Ile His Glu Asp Ser Leu Asn Val Asp Asp Asn Asn Val 
        835                 840                 845             


Leu Glu Glu Asp Ser Val Val Tyr Glu Trp Ala Leu Lys Lys Trp Ser 
    850                 855                 860                 


Pro Cys Ser Lys Pro Cys Gly Gly Gly Ser Gln Phe Thr Lys Tyr Gly 
865                 870                 875                 880 


Cys Arg Arg Arg Leu Asp His Lys Met Val His Arg Gly Phe Cys Ala 
                885                 890                 895     


Ala Leu Ser Lys Pro Lys Ala Ile Arg Arg Ala Cys Asn Pro Gln Glu 
            900                 905                 910         


Cys Ser Gln Pro Val Trp Val Thr Gly Glu Trp Glu Pro Cys Ser Gln 
        915                 920                 925             


Thr Cys Gly Arg Thr Gly Met Gln Val Arg Ser Val Arg Cys Ile Gln 
    930                 935                 940                 


Pro Leu His Asp Asn Thr Thr Arg Ser Val His Ala Lys His Cys Asn 
945                 950                 955                 960 


Asp Ala Arg Pro Glu Ser Arg Arg Ala Cys Ser Arg Glu Leu Cys Pro 
                965                 970                 975     


Gly Arg Trp Arg Ala Gly Pro Trp Ser Gln Cys Ser Val Thr Cys Gly 
            980                 985                 990         


Asn Gly Thr Gln Glu Arg Pro Val  Leu Cys Arg Thr Ala  Asp Asp Ser 
        995                 1000                 1005             


Phe Gly  Ile Cys Gln Glu Glu  Arg Pro Glu Thr Ala  Arg Thr Cys 
    1010                 1015                 1020             


Arg Leu  Gly Pro Cys Pro Arg  Asn Ile Ser Asp Pro  Ser Lys Lys 
    1025                 1030                 1035             


Ser Tyr  Val Val Gln Trp Leu  Ser Arg Pro Asp Pro  Asp Ser Pro 
    1040                 1045                 1050             


Ile Arg  Lys Ile Ser Ser Lys  Gly His Cys Gln Gly  Asp Lys Ser 
    1055                 1060                 1065             


Ile Phe  Cys Arg Met Glu Val  Leu Ser Arg Tyr Cys  Ser Ile Pro 
    1070                 1075                 1080             


Gly Tyr  Asn Lys Leu Cys Cys  Lys Ser Cys Asn Leu  Tyr Asn Asn 
    1085                 1090                 1095             


Leu Thr  Asn Val Glu Gly Arg  Ile Glu Pro Pro Pro  Gly Lys His 
    1100                 1105                 1110             


Asn Asp  Ile Asp Val Phe Met  Pro Thr Leu Pro Val  Pro Thr Val 
    1115                 1120                 1125             


Ala Met  Glu Val Arg Pro Ser  Pro Ser Thr Pro Leu  Glu Val Pro 
    1130                 1135                 1140             


Leu Asn  Ala Ser Ser Thr Asn  Ala Thr Glu Asp His  Pro Glu Thr 
    1145                 1150                 1155             


Asn Ala  Val Asp Glu Pro Tyr  Lys Ile His Gly Leu  Glu Asp Glu 
    1160                 1165                 1170             


Val Gln  Pro Pro Asn Leu Ile  Pro Arg Arg Pro Ser  Pro Tyr Glu 
    1175                 1180                 1185             


Lys Thr  Arg Asn Gln Arg Ile  Gln Glu Leu Ile Asp  Glu Met Arg 
    1190                 1195                 1200             


Lys Lys  Glu Met Leu Gly Lys  Phe 
    1205                 1210     


<210>  219
<211>  1205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS3__Homo_sapiens__NP_055058

<400>  219

Met Val Leu Leu Ser Leu Trp Leu Ile Ala Ala Ala Leu Val Glu Val 
1               5                   10                  15      


Arg Thr Ser Ala Asp Gly Gln Ala Gly Asn Glu Glu Met Val Gln Ile 
            20                  25                  30          


Asp Leu Pro Ile Lys Arg Tyr Arg Glu Tyr Glu Leu Val Thr Pro Val 
        35                  40                  45              


Ser Thr Asn Leu Glu Gly Arg Tyr Leu Ser His Thr Leu Ser Ala Ser 
    50                  55                  60                  


His Lys Lys Arg Ser Ala Arg Asp Val Ser Ser Asn Pro Glu Gln Leu 
65                  70                  75                  80  


Phe Phe Asn Ile Thr Ala Phe Gly Lys Asp Phe His Leu Arg Leu Lys 
                85                  90                  95      


Pro Asn Thr Gln Leu Val Ala Pro Gly Ala Val Val Glu Trp His Glu 
            100                 105                 110         


Thr Ser Leu Val Pro Gly Asn Ile Thr Asp Pro Ile Asn Asn His Gln 
        115                 120                 125             


Pro Gly Ser Ala Thr Tyr Arg Ile Arg Arg Thr Glu Pro Leu Gln Thr 
    130                 135                 140                 


Asn Cys Ala Tyr Val Gly Asp Ile Val Asp Ile Pro Gly Thr Ser Val 
145                 150                 155                 160 


Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Met Ile Lys Ser Asp Asn 
                165                 170                 175     


Glu Glu Tyr Phe Ile Glu Pro Leu Glu Arg Gly Lys Gln Met Glu Glu 
            180                 185                 190         


Glu Lys Gly Arg Ile His Val Val Tyr Lys Arg Ser Ala Val Glu Gln 
        195                 200                 205             


Ala Pro Ile Asp Met Ser Lys Asp Phe His Tyr Arg Glu Ser Asp Leu 
    210                 215                 220                 


Glu Gly Leu Asp Asp Leu Gly Thr Val Tyr Gly Asn Ile His Gln Gln 
225                 230                 235                 240 


Leu Asn Glu Thr Met Arg Arg Arg Arg His Ala Gly Glu Asn Asp Tyr 
                245                 250                 255     


Asn Ile Glu Val Leu Leu Gly Val Asp Asp Ser Val Val Arg Phe His 
            260                 265                 270         


Gly Lys Glu His Val Gln Asn Tyr Leu Leu Thr Leu Met Asn Ile Val 
        275                 280                 285             


Asn Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Val Val 
    290                 295                 300                 


Leu Val Arg Met Ile Met Leu Gly Tyr Ala Lys Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Asn Val Cys Arg Trp Ala 
                325                 330                 335     


Ser Gln Gln Gln Arg Ser Asp Leu Asn His Ser Glu His His Asp His 
            340                 345                 350         


Ala Ile Phe Leu Thr Arg Gln Asp Phe Gly Pro Ala Gly Met Gln Gly 
        355                 360                 365             


Tyr Ala Pro Val Thr Gly Met Cys His Pro Val Arg Ser Cys Thr Leu 
    370                 375                 380                 


Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Thr 
385                 390                 395                 400 


Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly 
                405                 410                 415     


Asp Glu Thr Ala Met Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala 
            420                 425                 430         


Phe His Arg Tyr His Trp Ser Arg Cys Ser Gly Gln Glu Leu Lys Arg 
        435                 440                 445             


Tyr Ile His Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp His Asp 
    450                 455                 460                 


Trp Pro Lys Leu Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu 
465                 470                 475                 480 


Gln Cys Arg Phe Asp Phe Gly Val Gly Tyr Lys Met Cys Thr Ala Phe 
                485                 490                 495     


Arg Thr Phe Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn 
            500                 505                 510         


Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu 
        515                 520                 525             


Cys Ala Ala Gly Lys Trp Cys Tyr Lys Gly His Cys Met Trp Lys Asn 
    530                 535                 540                 


Ala Asn Gln Gln Lys Gln Asp Gly Asn Trp Gly Ser Trp Thr Lys Phe 
545                 550                 555                 560 


Gly Ser Cys Ser Arg Thr Cys Gly Thr Gly Val Arg Phe Arg Thr Arg 
                565                 570                 575     


Gln Cys Asn Asn Pro Met Pro Ile Asn Gly Gly Gln Asp Cys Pro Gly 
            580                 585                 590         


Val Asn Phe Glu Tyr Gln Leu Cys Asn Thr Glu Glu Cys Gln Lys His 
        595                 600                 605             


Phe Glu Asp Phe Arg Ala Gln Gln Cys Gln Gln Arg Asn Ser His Phe 
    610                 615                 620                 


Glu Tyr Gln Asn Thr Lys His His Trp Leu Pro Tyr Glu His Pro Asp 
625                 630                 635                 640 


Pro Lys Lys Arg Cys His Leu Tyr Cys Gln Ser Lys Glu Thr Gly Asp 
                645                 650                 655     


Val Ala Tyr Met Lys Gln Leu Val His Asp Gly Thr His Cys Ser Tyr 
            660                 665                 670         


Lys Asp Pro Tyr Ser Ile Cys Val Arg Gly Glu Cys Val Lys Val Gly 
        675                 680                 685             


Cys Asp Lys Glu Ile Gly Ser Asn Lys Val Glu Asp Lys Cys Gly Val 
    690                 695                 700                 


Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Phe Thr 
705                 710                 715                 720 


Arg Thr Pro Arg Lys Leu Gly Tyr Leu Lys Met Phe Asp Ile Pro Pro 
                725                 730                 735     


Gly Ala Arg His Val Leu Ile Gln Glu Asp Glu Ala Ser Pro His Ile 
            740                 745                 750         


Leu Ala Ile Lys Asn Gln Ala Thr Gly His Tyr Ile Leu Asn Gly Lys 
        755                 760                 765             


Gly Glu Glu Ala Lys Ser Arg Thr Phe Ile Asp Leu Gly Val Glu Trp 
    770                 775                 780                 


Asp Tyr Asn Ile Glu Asp Asp Ile Glu Ser Leu His Thr Asp Gly Pro 
785                 790                 795                 800 


Leu His Asp Pro Val Ile Val Leu Ile Ile Pro Gln Glu Asn Asp Thr 
                805                 810                 815     


Arg Ser Ser Leu Thr Tyr Lys Tyr Ile Ile His Glu Asp Ser Val Pro 
            820                 825                 830         


Thr Ile Asn Ser Asn Asn Val Ile Gln Glu Glu Leu Asp Thr Phe Glu 
        835                 840                 845             


Trp Ala Leu Lys Ser Trp Ser Gln Cys Ser Lys Pro Cys Gly Gly Gly 
    850                 855                 860                 


Phe Gln Tyr Thr Lys Tyr Gly Cys Arg Arg Lys Ser Asp Asn Lys Met 
865                 870                 875                 880 


Val His Arg Ser Phe Cys Glu Ala Asn Lys Lys Pro Lys Pro Ile Arg 
                885                 890                 895     


Arg Met Cys Asn Ile Gln Glu Cys Thr His Pro Leu Trp Val Ala Glu 
            900                 905                 910         


Glu Trp Glu His Cys Thr Lys Thr Cys Gly Ser Ser Gly Tyr Gln Leu 
        915                 920                 925             


Arg Thr Val Arg Cys Leu Gln Pro Leu Leu Asp Gly Thr Asn Arg Ser 
    930                 935                 940                 


Val His Ser Lys Tyr Cys Met Gly Asp Arg Pro Glu Ser Arg Arg Pro 
945                 950                 955                 960 


Cys Asn Arg Val Pro Cys Pro Ala Gln Trp Lys Thr Gly Pro Trp Ser 
                965                 970                 975     


Glu Cys Ser Val Thr Cys Gly Glu Gly Thr Glu Val Arg Gln Val Leu 
            980                 985                 990         


Cys Arg Ala Gly Asp His Cys Asp  Gly Glu Lys Pro Glu  Ser Val Arg 
        995                 1000                 1005             


Ala Cys  Gln Leu Pro Pro Cys  Asn Asp Glu Pro Cys  Leu Gly Asp 
    1010                 1015                 1020             


Lys Ser  Ile Phe Cys Gln Met  Glu Val Leu Ala Arg  Tyr Cys Ser 
    1025                 1030                 1035             


Ile Pro  Gly Tyr Asn Lys Leu  Cys Cys Glu Ser Cys  Ser Lys Arg 
    1040                 1045                 1050             


Ser Ser  Thr Leu Pro Pro Pro  Tyr Leu Leu Glu Ala  Ala Glu Thr 
    1055                 1060                 1065             


His Asp  Asp Val Ile Ser Asn  Pro Ser Asp Leu Pro  Arg Ser Leu 
    1070                 1075                 1080             


Val Met  Pro Thr Ser Leu Val  Pro Tyr His Ser Glu  Thr Pro Ala 
    1085                 1090                 1095             


Lys Lys  Met Ser Leu Ser Ser  Ile Ser Ser Val Gly  Gly Pro Asn 
    1100                 1105                 1110             


Ala Tyr  Ala Ala Phe Arg Pro  Asn Ser Lys Pro Asp  Gly Ala Asn 
    1115                 1120                 1125             


Leu Arg  Gln Arg Ser Ala Gln  Gln Ala Gly Ser Lys  Thr Val Arg 
    1130                 1135                 1140             


Leu Val  Thr Val Pro Ser Ser  Pro Pro Thr Lys Arg  Val His Leu 
    1145                 1150                 1155             


Ser Ser  Ala Ser Gln Met Ala  Ala Ala Ser Phe Phe  Ala Ala Ser 
    1160                 1165                 1170             


Asp Ser  Ile Gly Ala Ser Ser  Gln Ala Arg Thr Ser  Lys Lys Asp 
    1175                 1180                 1185             


Gly Lys  Ile Ile Asp Asn Arg  Arg Pro Thr Arg Ser  Ser Thr Leu 
    1190                 1195                 1200             


Glu Arg  
    1205 


<210>  220
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS4__Homo_sapiens__NP_005090

<400>  220

Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp 
1               5                   10                  15      


Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser 
            20                  25                  30          


Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser 
        35                  40                  45              


Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro 
    50                  55                  60                  


Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg 
65                  70                  75                  80  


Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu 
                85                  90                  95      


Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu 
            100                 105                 110         


Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu 
        115                 120                 125             


Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp 
    130                 135                 140                 


Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu 
145                 150                 155                 160 


His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro 
                165                 170                 175     


Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro 
            180                 185                 190         


Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg 
        195                 200                 205             


Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val 
    210                 215                 220                 


Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg 
225                 230                 235                 240 


Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro 
                245                 250                 255     


Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu 
            260                 265                 270         


Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr 
        275                 280                 285             


Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp 
    290                 295                 300                 


Ser Asp Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp 
305                 310                 315                 320 


Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly 
                325                 330                 335     


Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly 
            340                 345                 350         


Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn 
        355                 360                 365             


Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu 
    370                 375                 380                 


Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro 
385                 390                 395                 400 


Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu 
                405                 410                 415     


Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu 
            420                 425                 430         


His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln 
        435                 440                 445             


Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro 
    450                 455                 460                 


Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala 
465                 470                 475                 480 


Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly 
                485                 490                 495     


Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu 
            500                 505                 510         


Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro 
        515                 520                 525             


Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser 
    530                 535                 540                 


Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu 
545                 550                 555                 560 


Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr 
                565                 570                 575     


Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His 
            580                 585                 590         


Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro 
        595                 600                 605             


Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln 
    610                 615                 620                 


Ala Gln Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp 
625                 630                 635                 640 


Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg 
                645                 650                 655     


Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe 
            660                 665                 670         


Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln 
        675                 680                 685             


Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr 
    690                 695                 700                 


Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro 
705                 710                 715                 720 


Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr 
                725                 730                 735     


Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val 
            740                 745                 750         


Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser 
        755                 760                 765             


Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln 
    770                 775                 780                 


Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe 
785                 790                 795                 800 


Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp 
                805                 810                 815     


Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro 
            820                 825                 830         


Trp Ala Gly Arg Lys 
        835         


<210>  221
<211>  930
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS5__Homo_sapiens__NP_008969

<400>  221

Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro 
1               5                   10                  15      


Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly 
            20                  25                  30          


Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly 
        35                  40                  45              


Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu 
    50                  55                  60                  


Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg 
                85                  90                  95      


Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly 
            100                 105                 110         


Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser 
        115                 120                 125             


His Cys Phe Tyr Arg Gly Thr Val Asp Gly Ser Pro Arg Ser Leu Ala 
    130                 135                 140                 


Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His 
145                 150                 155                 160 


Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu 
                165                 170                 175     


Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val 
            180                 185                 190         


Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser 
        195                 200                 205             


Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala 
    210                 215                 220                 


His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp 
225                 230                 235                 240 


Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp 
                245                 250                 255     


Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu 
            260                 265                 270         


Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln 
        275                 280                 285             


His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His 
    290                 295                 300                 


Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val 
305                 310                 315                 320 


Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr 
                325                 330                 335     


Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly 
            340                 345                 350         


Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu 
        355                 360                 365             


Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val 
    370                 375                 380                 


Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp 
385                 390                 395                 400 


Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu 
                405                 410                 415     


Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser 
            420                 425                 430         


Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala 
        435                 440                 445             


Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu 
    450                 455                 460                 


Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile 
465                 470                 475                 480 


Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln 
                485                 490                 495     


Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp 
            500                 505                 510         


Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val 
        515                 520                 525             


Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys 
    530                 535                 540                 


Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys 
545                 550                 555                 560 


Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp 
                565                 570                 575     


Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg 
            580                 585                 590         


His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly 
        595                 600                 605             


Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn 
    610                 615                 620                 


Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln 
625                 630                 635                 640 


Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr 
                645                 650                 655     


Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys 
            660                 665                 670         


Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr 
        675                 680                 685             


Glu Cys Arg Leu Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val 
    690                 695                 700                 


Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys 
705                 710                 715                 720 


Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly 
                725                 730                 735     


Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro 
            740                 745                 750         


Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln 
        755                 760                 765             


Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr 
    770                 775                 780                 


Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp 
785                 790                 795                 800 


Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp 
                805                 810                 815     


Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val 
            820                 825                 830         


Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser 
        835                 840                 845             


Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser 
    850                 855                 860                 


His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val 
865                 870                 875                 880 


Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His 
                885                 890                 895     


Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly 
            900                 905                 910         


Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys 
        915                 920                 925             


Lys Cys 
    930 


<210>  222
<211>  1117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS6__Homo_sapiens__NP_922932

<400>  222

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


Trp Gly Pro Trp Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
                565                 570                 575     


Gly Val Ser Ser Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly 
            580                 585                 590         


Gly Gly Lys Tyr Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn 
        595                 600                 605             


Thr Asp Pro Cys Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys 
    610                 615                 620                 


Ala Asp Phe Asp Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys 
625                 630                 635                 640 


Pro Tyr Thr Gly Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala 
                645                 650                 655     


Glu Gly Tyr Asn Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly 
            660                 665                 670         


Thr Gln Cys Asn Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys 
        675                 680                 685             


Lys His Val Gly Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp 
    690                 695                 700                 


Arg Cys Arg Val Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala Ile Glu 
705                 710                 715                 720 


Gly Phe Phe Asn Asp Ser Leu Pro Arg Gly Gly Tyr Met Glu Val Val 
                725                 730                 735     


Gln Ile Pro Arg Gly Ser Val His Ile Glu Val Arg Glu Val Ala Met 
            740                 745                 750         


Ser Lys Asn Tyr Ile Ala Leu Lys Ser Glu Gly Asp Asp Tyr Tyr Ile 
        755                 760                 765             


Asn Gly Ala Trp Thr Ile Asp Trp Pro Arg Lys Phe Asp Val Ala Gly 
    770                 775                 780                 


Thr Ala Phe His Tyr Lys Arg Pro Thr Asp Glu Pro Glu Ser Leu Glu 
785                 790                 795                 800 


Ala Leu Gly Pro Thr Ser Glu Asn Leu Ile Val Met Val Leu Leu Gln 
                805                 810                 815     


Glu Gln Asn Leu Gly Ile Arg Tyr Lys Phe Asn Val Pro Ile Thr Arg 
            820                 825                 830         


Thr Gly Ser Gly Asp Asn Glu Val Gly Phe Thr Trp Asn His Gln Pro 
        835                 840                 845             


Trp Ser Glu Cys Ser Ala Thr Cys Ala Gly Gly Val Gln Arg Gln Glu 
    850                 855                 860                 


Val Val Cys Lys Arg Leu Asp Asp Asn Ser Ile Val Gln Asn Asn Tyr 
865                 870                 875                 880 


Cys Asp Pro Asp Ser Lys Pro Pro Glu Asn Gln Arg Ala Cys Asn Thr 
                885                 890                 895     


Glu Pro Cys Pro Pro Glu Trp Phe Ile Gly Asp Trp Leu Glu Cys Ser 
            900                 905                 910         


Lys Thr Cys Asp Gly Gly Met Arg Thr Arg Ala Val Leu Cys Ile Arg 
        915                 920                 925             


Lys Ile Gly Pro Ser Glu Glu Glu Thr Leu Asp Tyr Ser Gly Cys Leu 
    930                 935                 940                 


Thr His Arg Pro Val Glu Lys Glu Pro Cys Asn Asn Gln Ser Cys Pro 
945                 950                 955                 960 


Pro Gln Trp Val Ala Leu Asp Trp Ser Glu Cys Thr Pro Lys Cys Gly 
                965                 970                 975     


Pro Gly Phe Lys His Arg Ile Val Leu Cys Lys Ser Ser Asp Leu Ser 
            980                 985                 990         


Lys Thr Phe Pro Ala Ala Gln Cys  Pro Glu Glu Ser Lys  Pro Pro Val 
        995                 1000                 1005             


Arg Ile  Arg Cys Ser Leu Gly  Arg Cys Pro Pro Pro  Arg Trp Val 
    1010                 1015                 1020             


Thr Gly  Asp Trp Gly Gln Cys  Ser Ala Gln Cys Gly  Leu Gly Gln 
    1025                 1030                 1035             


Gln Met  Arg Thr Val Gln Cys  Leu Ser Tyr Thr Gly  Gln Ala Ser 
    1040                 1045                 1050             


Ser Asp  Cys Leu Glu Thr Val  Arg Pro Pro Ser Met  Gln Gln Cys 
    1055                 1060                 1065             


Glu Ser  Lys Cys Asp Ser Thr  Pro Ile Ser Asn Thr  Glu Glu Cys 
    1070                 1075                 1080             


Lys Asp  Val Asn Lys Val Ala  Tyr Cys Pro Leu Val  Leu Lys Phe 
    1085                 1090                 1095             


Lys Phe  Cys Ser Arg Ala Tyr  Phe Arg Gln Met Cys  Cys Lys Thr 
    1100                 1105                 1110             


Cys Gln  Gly His 
    1115         


<210>  223
<211>  1686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS7__Homo_sapiens__NP_055087

<400>  223

Met Pro Gly Gly Pro Ser Pro Arg Ser Pro Ala Pro Leu Leu Arg Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Cys Ala Leu Ala Pro Gly Ala Pro Gly Pro Ala 
            20                  25                  30          


Pro Gly Arg Ala Thr Glu Gly Arg Ala Ala Leu Asp Ile Val His Pro 
        35                  40                  45              


Val Arg Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr Glu Leu Trp Pro 
    50                  55                  60                  


Arg Ala Leu Arg Lys Arg Asp Val Ser Val Arg Arg Asp Ala Pro Ala 
65                  70                  75                  80  


Phe Tyr Glu Leu Gln Tyr Arg Gly Arg Glu Leu Arg Phe Asn Leu Thr 
                85                  90                  95      


Ala Asn Gln His Leu Leu Ala Pro Gly Phe Val Ser Glu Thr Arg Arg 
            100                 105                 110         


Arg Gly Gly Leu Gly Arg Ala His Ile Arg Ala His Thr Pro Ala Cys 
        115                 120                 125             


His Leu Leu Gly Glu Val Gln Asp Pro Glu Leu Glu Gly Gly Leu Ala 
    130                 135                 140                 


Ala Ile Ser Ala Cys Asp Gly Leu Lys Gly Val Phe Gln Leu Ser Asn 
145                 150                 155                 160 


Glu Asp Tyr Phe Ile Glu Pro Leu Asp Ser Ala Pro Ala Arg Pro Gly 
                165                 170                 175     


His Ala Gln Pro His Val Val Tyr Lys Arg Gln Ala Pro Glu Arg Leu 
            180                 185                 190         


Ala Gln Arg Gly Asp Ser Ser Ala Pro Ser Thr Cys Gly Val Gln Val 
        195                 200                 205             


Tyr Pro Glu Leu Glu Ser Arg Arg Glu Arg Trp Glu Gln Arg Gln Gln 
    210                 215                 220                 


Trp Arg Arg Pro Arg Leu Arg Arg Leu His Gln Arg Ser Val Ser Lys 
225                 230                 235                 240 


Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ala Lys Met Val Glu 
                245                 250                 255     


Tyr His Gly Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn 
            260                 265                 270         


Met Val Ala Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His 
        275                 280                 285             


Ile Thr Ile Val Arg Leu Val Leu Leu Glu Asp Glu Glu Glu Asp Leu 
    290                 295                 300                 


Lys Ile Thr His His Ala Asp Asn Thr Leu Lys Ser Phe Cys Lys Trp 
305                 310                 315                 320 


Gln Lys Ser Ile Asn Met Lys Gly Asp Ala His Pro Leu His His Asp 
                325                 330                 335     


Thr Ala Ile Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala Met Asn Arg 
            340                 345                 350         


Pro Cys Glu Thr Leu Gly Leu Ser His Val Ala Gly Met Cys Gln Pro 
        355                 360                 365             


His Arg Ser Cys Ser Ile Asn Glu Asp Thr Gly Leu Pro Leu Ala Phe 
    370                 375                 380                 


Thr Val Ala His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly 
385                 390                 395                 400 


Ser Gly Asn Asp Cys Glu Pro Val Gly Lys Arg Pro Phe Ile Met Ser 
                405                 410                 415     


Pro Gln Leu Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser Arg Cys Ser 
            420                 425                 430         


Arg Gln Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu 
        435                 440                 445             


Asp Asp Pro Pro Ala Lys Asp Ile Ile Asp Phe Pro Ser Val Pro Pro 
    450                 455                 460                 


Gly Val Leu Tyr Asp Val Ser His Gln Cys Arg Leu Gln Tyr Gly Ala 
465                 470                 475                 480 


Tyr Ser Ala Phe Cys Glu Asp Met Asp Asn Val Cys His Thr Leu Trp 
                485                 490                 495     


Cys Ser Val Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val Asp 
            500                 505                 510         


Gly Thr Arg Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly Glu Cys Val 
        515                 520                 525             


Pro Val Gly Phe Arg Pro Glu Ala Val Asp Gly Gly Trp Ser Gly Trp 
    530                 535                 540                 


Ser Ala Trp Ser Ile Cys Ser Arg Ser Cys Gly Met Gly Val Gln Ser 
545                 550                 555                 560 


Ala Glu Arg Gln Cys Thr Gln Pro Thr Pro Lys Tyr Lys Gly Arg Tyr 
                565                 570                 575     


Cys Val Gly Glu Arg Lys Arg Phe Arg Leu Cys Asn Leu Gln Ala Cys 
            580                 585                 590         


Pro Ala Gly Arg Pro Ser Phe Arg His Val Gln Cys Ser His Phe Asp 
        595                 600                 605             


Ala Met Leu Tyr Lys Gly Gln Leu His Thr Trp Val Pro Val Val Asn 
    610                 615                 620                 


Asp Val Asn Pro Cys Glu Leu His Cys Arg Pro Ala Asn Glu Tyr Phe 
625                 630                 635                 640 


Ala Glu Lys Leu Arg Asp Ala Val Val Asp Gly Thr Pro Cys Tyr Gln 
                645                 650                 655     


Val Arg Ala Ser Arg Asp Leu Cys Ile Asn Gly Ile Cys Lys Asn Val 
            660                 665                 670         


Gly Cys Asp Phe Glu Ile Asp Ser Gly Ala Met Glu Asp Arg Cys Gly 
        675                 680                 685             


Val Cys His Gly Asn Gly Ser Thr Cys His Thr Val Ser Gly Thr Phe 
    690                 695                 700                 


Glu Glu Ala Glu Gly Leu Gly Tyr Val Asp Val Gly Leu Ile Pro Ala 
705                 710                 715                 720 


Gly Ala Arg Glu Ile Arg Ile Gln Glu Val Ala Glu Ala Ala Asn Phe 
                725                 730                 735     


Leu Ala Leu Arg Ser Glu Asp Pro Glu Lys Tyr Phe Leu Asn Gly Gly 
            740                 745                 750         


Trp Thr Ile Gln Trp Asn Gly Asp Tyr Gln Val Ala Gly Thr Thr Phe 
        755                 760                 765             


Thr Tyr Ala Arg Arg Gly Asn Trp Glu Asn Leu Thr Ser Pro Gly Pro 
    770                 775                 780                 


Thr Lys Glu Pro Val Trp Ile Gln Leu Leu Phe Gln Glu Ser Asn Pro 
785                 790                 795                 800 


Gly Val His Tyr Glu Tyr Thr Ile His Arg Glu Ala Gly Gly His Asp 
                805                 810                 815     


Glu Val Pro Pro Pro Val Phe Ser Trp His Tyr Gly Pro Trp Thr Lys 
            820                 825                 830         


Cys Thr Val Thr Cys Gly Arg Gly Val Gln Arg Gln Asn Val Tyr Cys 
        835                 840                 845             


Leu Glu Arg Gln Ala Gly Pro Val Asp Glu Glu His Cys Asp Pro Leu 
    850                 855                 860                 


Gly Arg Pro Asp Asp Gln Gln Arg Lys Cys Ser Glu Gln Pro Cys Pro 
865                 870                 875                 880 


Ala Arg Trp Trp Ala Gly Glu Trp Gln Leu Cys Ser Ser Ser Cys Gly 
                885                 890                 895     


Pro Gly Gly Leu Ser Arg Arg Ala Val Leu Cys Ile Arg Ser Val Gly 
            900                 905                 910         


Leu Asp Glu Gln Ser Ala Leu Glu Pro Pro Ala Cys Glu His Leu Pro 
        915                 920                 925             


Arg Pro Pro Thr Glu Thr Pro Cys Asn Arg His Val Pro Cys Pro Ala 
    930                 935                 940                 


Thr Trp Ala Val Gly Asn Trp Ser Gln Cys Ser Val Thr Cys Gly Glu 
945                 950                 955                 960 


Gly Thr Gln Arg Arg Asn Val Leu Cys Thr Asn Asp Thr Gly Val Pro 
                965                 970                 975     


Cys Asp Glu Ala Gln Gln Pro Ala Ser Glu Val Thr Cys Ser Leu Pro 
            980                 985                 990         


Leu Cys Arg Trp Pro Leu Gly Thr  Leu Gly Pro Glu Gly  Ser Gly Ser 
        995                 1000                 1005             


Gly Ser  Ser Ser His Glu Leu  Phe Asn Glu Ala Asp  Phe Ile Pro 
    1010                 1015                 1020             


His His  Leu Ala Pro Arg Pro  Ser Pro Ala Ser Ser  Pro Lys Pro 
    1025                 1030                 1035             


Gly Thr  Met Gly Asn Ala Ile  Glu Glu Glu Ala Pro  Glu Leu Asp 
    1040                 1045                 1050             


Leu Pro  Gly Pro Val Phe Val  Asp Asp Phe Tyr Tyr  Asp Tyr Asn 
    1055                 1060                 1065             


Phe Ile  Asn Phe His Glu Asp  Leu Ser Tyr Gly Pro  Ser Glu Glu 
    1070                 1075                 1080             


Pro Asp  Leu Asp Leu Ala Gly  Thr Gly Asp Arg Thr  Pro Pro Pro 
    1085                 1090                 1095             


His Ser  His Pro Ala Ala Pro  Ser Thr Gly Ser Pro  Val Pro Ala 
    1100                 1105                 1110             


Thr Glu  Pro Pro Ala Ala Lys  Glu Glu Gly Val Leu  Gly Pro Trp 
    1115                 1120                 1125             


Ser Pro  Ser Pro Trp Pro Ser  Gln Ala Gly Arg Ser  Pro Pro Pro 
    1130                 1135                 1140             


Pro Ser  Glu Gln Thr Pro Gly  Asn Pro Leu Ile Asn  Phe Leu Pro 
    1145                 1150                 1155             


Glu Glu  Asp Thr Pro Ile Gly  Ala Pro Asp Leu Gly  Leu Pro Ser 
    1160                 1165                 1170             


Leu Ser  Trp Pro Arg Val Ser  Thr Asp Gly Leu Gln  Thr Pro Ala 
    1175                 1180                 1185             


Thr Pro  Glu Ser Gln Asn Asp  Phe Pro Val Gly Lys  Asp Ser Gln 
    1190                 1195                 1200             


Ser Gln  Leu Pro Pro Pro Trp  Arg Asp Arg Thr Asn  Glu Val Phe 
    1205                 1210                 1215             


Lys Asp  Asp Glu Glu Pro Lys  Gly Arg Gly Ala Pro  His Leu Pro 
    1220                 1225                 1230             


Pro Arg  Pro Ser Ser Thr Leu  Pro Pro Leu Ser Pro  Val Gly Ser 
    1235                 1240                 1245             


Thr His  Ser Ser Pro Ser Pro  Asp Val Ala Glu Leu  Trp Thr Gly 
    1250                 1255                 1260             


Gly Thr  Val Ala Trp Glu Pro  Ala Leu Glu Gly Gly  Leu Gly Pro 
    1265                 1270                 1275             


Val Asp  Ser Glu Leu Trp Pro  Thr Val Gly Val Ala  Ser Leu Leu 
    1280                 1285                 1290             


Pro Pro  Pro Ile Ala Pro Leu  Pro Glu Met Lys Val  Arg Asp Ser 
    1295                 1300                 1305             


Ser Leu  Glu Pro Gly Thr Pro  Ser Phe Pro Thr Pro  Gly Pro Gly 
    1310                 1315                 1320             


Ser Trp  Asp Leu Gln Thr Val  Ala Val Trp Gly Thr  Phe Leu Pro 
    1325                 1330                 1335             


Thr Thr  Leu Thr Gly Leu Gly  His Met Pro Glu Pro  Ala Leu Asn 
    1340                 1345                 1350             


Pro Gly  Pro Lys Gly Gln Pro  Glu Ser Leu Ser Pro  Glu Val Pro 
    1355                 1360                 1365             


Leu Ser  Ser Arg Leu Leu Ser  Thr Pro Ala Trp Asp  Ser Pro Ala 
    1370                 1375                 1380             


Asn Ser  His Arg Val Pro Glu  Thr Gln Pro Leu Ala  Pro Ser Leu 
    1385                 1390                 1395             


Ala Glu  Ala Gly Pro Pro Ala  Asp Pro Leu Val Val  Arg Asn Ala 
    1400                 1405                 1410             


Gly Trp  Gln Ala Gly Asn Trp  Ser Glu Cys Ser Thr  Thr Cys Gly 
    1415                 1420                 1425             


Leu Gly  Ala Val Trp Arg Pro  Val Arg Cys Ser Ser  Gly Arg Asp 
    1430                 1435                 1440             


Glu Asp  Cys Ala Pro Ala Gly  Arg Pro Gln Pro Ala  Arg Arg Cys 
    1445                 1450                 1455             


His Leu  Arg Pro Cys Ala Thr  Trp His Ser Gly Asn  Trp Ser Lys 
    1460                 1465                 1470             


Cys Ser  Arg Ser Cys Gly Gly  Gly Ser Ser Val Arg  Asp Val Gln 
    1475                 1480                 1485             


Cys Val  Asp Thr Arg Asp Leu  Arg Pro Leu Arg Pro  Phe His Cys 
    1490                 1495                 1500             


Gln Pro  Gly Pro Ala Lys Pro  Pro Ala His Arg Pro  Cys Gly Ala 
    1505                 1510                 1515             


Gln Pro  Cys Leu Ser Trp Tyr  Thr Ser Ser Trp Arg  Glu Cys Ser 
    1520                 1525                 1530             


Glu Ala  Cys Gly Gly Gly Glu  Gln Gln Arg Leu Val  Thr Cys Pro 
    1535                 1540                 1545             


Glu Pro  Gly Leu Cys Glu Glu  Ala Leu Arg Pro Asn  Thr Thr Arg 
    1550                 1555                 1560             


Pro Cys  Asn Thr His Pro Cys  Thr Gln Trp Val Val  Gly Pro Trp 
    1565                 1570                 1575             


Gly Gln  Cys Ser Gly Pro Cys  Gly Gly Gly Val Gln  Arg Arg Leu 
    1580                 1585                 1590             


Val Lys  Cys Val Asn Thr Gln  Thr Gly Leu Pro Glu  Glu Asp Ser 
    1595                 1600                 1605             


Asp Gln  Cys Gly His Glu Ala  Trp Pro Glu Ser Ser  Arg Pro Cys 
    1610                 1615                 1620             


Gly Thr  Glu Asp Cys Glu Pro  Val Glu Pro Pro Arg  Cys Glu Arg 
    1625                 1630                 1635             


Asp Arg  Leu Ser Phe Gly Phe  Cys Glu Thr Leu Arg  Leu Leu Gly 
    1640                 1645                 1650             


Arg Cys  Gln Leu Pro Thr Ile  Arg Thr Gln Cys Cys  Arg Ser Cys 
    1655                 1660                 1665             


Ser Pro  Pro Ser His Gly Ala  Pro Ser Arg Gly His  Gln Arg Val 
    1670                 1675                 1680             


Ala Arg  Arg 
    1685     


<210>  224
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS8__Homo_sapiens__NP_008968

<400>  224

Met Leu Pro Ala Pro Ala Ala Pro Arg Trp Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ala Arg Gly Ala Pro Ala Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Gln Ala Ser Glu Leu Val Val Pro Thr Arg Leu Pro Gly 
        35                  40                  45              


Ser Ala Gly Glu Leu Ala Leu His Leu Ser Ala Phe Gly Lys Gly Phe 
    50                  55                  60                  


Val Leu Arg Leu Ala Pro Asp Asp Ser Phe Leu Ala Pro Glu Phe Lys 
65                  70                  75                  80  


Ile Glu Arg Leu Gly Gly Ser Gly Arg Ala Thr Gly Gly Glu Arg Gly 
                85                  90                  95      


Leu Arg Gly Cys Phe Phe Ser Gly Thr Val Asn Gly Glu Pro Glu Ser 
            100                 105                 110         


Leu Ala Ala Val Ser Leu Cys Arg Gly Leu Ser Gly Ser Phe Leu Leu 
        115                 120                 125             


Asp Gly Glu Glu Phe Thr Ile Gln Pro Gln Gly Ala Gly Gly Ser Leu 
    130                 135                 140                 


Ala Gln Pro His Arg Leu Gln Arg Trp Gly Pro Ala Gly Ala Arg Pro 
145                 150                 155                 160 


Leu Pro Arg Gly Pro Glu Trp Glu Val Glu Thr Gly Glu Gly Gln Arg 
                165                 170                 175     


Gln Glu Arg Gly Asp His Gln Glu Asp Ser Glu Glu Glu Ser Gln Glu 
            180                 185                 190         


Glu Glu Ala Glu Gly Ala Ser Glu Pro Pro Pro Pro Leu Gly Ala Thr 
        195                 200                 205             


Ser Arg Thr Lys Arg Phe Val Ser Glu Ala Arg Phe Val Glu Thr Leu 
    210                 215                 220                 


Leu Val Ala Asp Ala Ser Met Ala Ala Phe Tyr Gly Ala Asp Leu Gln 
225                 230                 235                 240 


Asn His Ile Leu Thr Leu Met Ser Val Ala Ala Arg Ile Tyr Lys His 
                245                 250                 255     


Pro Ser Ile Lys Asn Ser Ile Asn Leu Met Val Val Lys Val Leu Ile 
            260                 265                 270         


Val Glu Asp Glu Lys Trp Gly Pro Glu Val Ser Asp Asn Gly Gly Leu 
        275                 280                 285             


Thr Leu Arg Asn Phe Cys Asn Trp Gln Arg Arg Phe Asn Gln Pro Ser 
    290                 295                 300                 


Asp Arg His Pro Glu His Tyr Asp Thr Ala Ile Leu Leu Thr Arg Gln 
305                 310                 315                 320 


Asn Phe Cys Gly Gln Glu Gly Leu Cys Asp Thr Leu Gly Val Ala Asp 
                325                 330                 335     


Ile Gly Thr Ile Cys Asp Pro Asn Lys Ser Cys Ser Val Ile Glu Asp 
            340                 345                 350         


Glu Gly Leu Gln Ala Ala His Thr Leu Ala His Glu Leu Gly His Val 
        355                 360                 365             


Leu Ser Met Pro His Asp Asp Ser Lys Pro Cys Thr Arg Leu Phe Gly 
    370                 375                 380                 


Pro Met Gly Lys His His Val Met Ala Pro Leu Phe Val His Leu Asn 
385                 390                 395                 400 


Gln Thr Leu Pro Trp Ser Pro Cys Ser Ala Met Tyr Leu Thr Glu Leu 
                405                 410                 415     


Leu Asp Gly Gly His Gly Asp Cys Leu Leu Asp Ala Pro Ala Ala Ala 
            420                 425                 430         


Leu Pro Leu Pro Thr Gly Leu Pro Gly Arg Met Ala Leu Tyr Gln Leu 
        435                 440                 445             


Asp Gln Gln Cys Arg Gln Ile Phe Gly Pro Asp Phe Arg His Cys Pro 
    450                 455                 460                 


Asn Thr Ser Ala Gln Asp Val Cys Ala Gln Leu Trp Cys His Thr Asp 
465                 470                 475                 480 


Gly Ala Glu Pro Leu Cys His Thr Lys Asn Gly Ser Leu Pro Trp Ala 
                485                 490                 495     


Asp Gly Thr Pro Cys Gly Pro Gly His Leu Cys Ser Glu Gly Ser Cys 
            500                 505                 510         


Leu Pro Glu Glu Glu Val Glu Arg Pro Lys Pro Val Ala Asp Gly Gly 
        515                 520                 525             


Trp Ala Pro Trp Gly Pro Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
    530                 535                 540                 


Gly Val Gln Phe Ser His Arg Glu Cys Lys Asp Pro Glu Pro Gln Asn 
545                 550                 555                 560 


Gly Gly Arg Tyr Cys Leu Gly Arg Arg Ala Lys Tyr Gln Ser Cys His 
                565                 570                 575     


Thr Glu Glu Cys Pro Pro Asp Gly Lys Ser Phe Arg Glu Gln Gln Cys 
            580                 585                 590         


Glu Lys Tyr Asn Ala Tyr Asn Tyr Thr Asp Met Asp Gly Asn Leu Leu 
        595                 600                 605             


Gln Trp Val Pro Lys Tyr Ala Gly Val Ser Pro Arg Asp Arg Cys Lys 
    610                 615                 620                 


Leu Phe Cys Arg Ala Arg Gly Arg Ser Glu Phe Lys Val Phe Glu Ala 
625                 630                 635                 640 


Lys Val Ile Asp Gly Thr Leu Cys Gly Pro Glu Thr Leu Ala Ile Cys 
                645                 650                 655     


Val Arg Gly Gln Cys Val Lys Ala Gly Cys Asp His Val Val Asp Ser 
            660                 665                 670         


Pro Arg Lys Leu Asp Lys Cys Gly Val Cys Gly Gly Lys Gly Asn Ser 
        675                 680                 685             


Cys Arg Lys Val Ser Gly Ser Leu Thr Pro Thr Asn Tyr Gly Tyr Asn 
    690                 695                 700                 


Asp Ile Val Thr Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Lys Gln 
705                 710                 715                 720 


Arg Ser His Pro Gly Val Gln Asn Asp Gly Asn Tyr Leu Ala Leu Lys 
                725                 730                 735     


Thr Ala Asp Gly Gln Tyr Leu Leu Asn Gly Asn Leu Ala Ile Ser Ala 
            740                 745                 750         


Ile Glu Gln Asp Ile Leu Val Lys Gly Thr Ile Leu Lys Tyr Ser Gly 
        755                 760                 765             


Ser Ile Ala Thr Leu Glu Arg Leu Gln Ser Phe Arg Pro Leu Pro Glu 
    770                 775                 780                 


Pro Leu Thr Val Gln Leu Leu Thr Val Pro Gly Glu Val Phe Pro Pro 
785                 790                 795                 800 


Lys Val Lys Tyr Thr Phe Phe Val Pro Asn Asp Val Asp Phe Ser Met 
                805                 810                 815     


Gln Ser Ser Lys Glu Arg Ala Thr Thr Asn Ile Ile Gln Pro Leu Leu 
            820                 825                 830         


His Ala Gln Trp Val Leu Gly Asp Trp Ser Glu Cys Ser Ser Thr Cys 
        835                 840                 845             


Gly Ala Gly Trp Gln Arg Arg Thr Val Glu Cys Arg Asp Pro Ser Gly 
    850                 855                 860                 


Gln Ala Ser Ala Thr Cys Asn Lys Ala Leu Lys Pro Glu Asp Ala Lys 
865                 870                 875                 880 


Pro Cys Glu Ser Gln Leu Cys Pro Leu 
                885                 


<210>  225
<211>  1935
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS9__Homo_sapiens__NP_891550

<400>  225

Met Gln Phe Val Ser Trp Ala Thr Leu Leu Thr Leu Leu Val Arg Asp 
1               5                   10                  15      


Leu Ala Glu Met Gly Ser Pro Asp Ala Ala Ala Ala Val Arg Lys Asp 
            20                  25                  30          


Arg Leu His Pro Arg Gln Val Lys Leu Leu Glu Thr Leu Ser Glu Tyr 
        35                  40                  45              


Glu Ile Val Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro 
    50                  55                  60                  


Thr Asn Val His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Trp Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser 
                85                  90                  95      


Gln Ala His Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn 
            100                 105                 110         


Leu Thr Ala Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu 
        115                 120                 125             


Leu Gly Thr Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu 
    130                 135                 140                 


Ala Glu Leu Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser 
145                 150                 155                 160 


Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe 
                165                 170                 175     


Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp 
            180                 185                 190         


Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg 
        195                 200                 205             


Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp 
    210                 215                 220                 


Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg 
225                 230                 235                 240 


Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala 
                245                 250                 255     


Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys 
            260                 265                 270         


Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe 
        275                 280                 285             


Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg 
    290                 295                 300                 


Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu 
305                 310                 315                 320 


Met Ser Ile Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu 
                325                 330                 335     


Ile Asn Ile Val Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp 
            340                 345                 350         


Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys 
        355                 360                 365             


Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr 
    370                 375                 380                 


Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys 
385                 390                 395                 400 


Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg 
                405                 410                 415     


Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile 
            420                 425                 430         


Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn 
        435                 440                 445             


Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro 
    450                 455                 460                 


Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg 
465                 470                 475                 480 


Lys Tyr Ile Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu 
                485                 490                 495     


Asn Glu Pro Glu Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu Pro Gly 
            500                 505                 510         


Ile Leu Tyr Asn Val Asn Lys Gln Cys Glu Leu Ile Phe Gly Pro Gly 
        515                 520                 525             


Ser Gln Val Cys Pro Tyr Met Met Gln Cys Arg Arg Leu Trp Cys Asn 
    530                 535                 540                 


Asn Val Asn Gly Val His Lys Gly Cys Arg Thr Gln His Thr Pro Trp 
545                 550                 555                 560 


Ala Asp Gly Thr Glu Cys Glu Pro Gly Lys His Cys Lys Tyr Gly Phe 
                565                 570                 575     


Cys Val Pro Lys Glu Met Asp Val Pro Val Thr Asp Gly Ser Trp Gly 
            580                 585                 590         


Ser Trp Ser Pro Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly Gly Ile 
        595                 600                 605             


Lys Thr Ala Ile Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn Gly Gly 
    610                 615                 620                 


Lys Tyr Cys Val Gly Arg Arg Met Lys Phe Lys Ser Cys Asn Thr Glu 
625                 630                 635                 640 


Pro Cys Leu Lys Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys Ala His 
                645                 650                 655     


Phe Asp Gly Lys His Phe Asn Ile Asn Gly Leu Leu Pro Asn Val Arg 
            660                 665                 670         


Trp Val Pro Lys Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys Lys Leu 
        675                 680                 685             


Phe Cys Arg Val Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg Asp Arg 
    690                 695                 700                 


Val Ile Asp Gly Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile Cys Val 
705                 710                 715                 720 


Gln Gly Leu Cys Arg Gln Ala Gly Cys Asp His Val Leu Asn Ser Lys 
                725                 730                 735     


Ala Arg Arg Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys 
            740                 745                 750         


Lys Thr Val Ala Gly Thr Phe Asn Thr Val His Tyr Gly Tyr Asn Thr 
        755                 760                 765             


Val Val Arg Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Arg Gln His 
    770                 775                 780                 


Ser Phe Ser Gly Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu Ser Ser 
785                 790                 795                 800 


Ser Lys Gly Glu Phe Leu Leu Asn Gly Asn Phe Val Val Thr Met Ala 
                805                 810                 815     


Lys Arg Glu Ile Arg Ile Gly Asn Ala Val Val Glu Tyr Ser Gly Ser 
            820                 825                 830         


Glu Thr Ala Val Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu Gln Glu 
        835                 840                 845             


Leu Leu Leu Gln Val Leu Ser Val Gly Lys Leu Tyr Asn Pro Asp Val 
    850                 855                 860                 


Arg Tyr Ser Phe Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln Phe Tyr 
865                 870                 875                 880 


Trp Asn Ser His Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys Gln Gly 
                885                 890                 895     


Glu Arg Lys Arg Lys Leu Val Cys Thr Arg Glu Ser Asp Gln Leu Thr 
            900                 905                 910         


Val Ser Asp Gln Arg Cys Asp Arg Leu Pro Gln Pro Gly His Ile Thr 
        915                 920                 925             


Glu Pro Cys Gly Thr Asp Cys Asp Leu Arg Trp His Val Ala Ser Arg 
    930                 935                 940                 


Ser Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile 
945                 950                 955                 960 


Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp 
                965                 970                 975     


Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys 
            980                 985                 990         


Ser Gly Glu Cys Asn Thr Gly Gly  Trp Arg Tyr Ser Ala  Trp Thr Glu 
        995                 1000                 1005             


Cys Ser  Lys Ser Cys Asp Gly  Gly Thr Gln Arg Arg  Arg Ala Ile 
    1010                 1015                 1020             


Cys Val  Asn Thr Arg Asn Asp  Val Leu Asp Asp Ser  Lys Cys Thr 
    1025                 1030                 1035             


His Gln  Glu Lys Val Thr Ile  Gln Arg Cys Ser Glu  Phe Pro Cys 
    1040                 1045                 1050             


Pro Gln  Trp Lys Ser Gly Asp  Trp Ser Glu Cys Leu  Val Thr Cys 
    1055                 1060                 1065             


Gly Lys  Gly His Lys His Arg  Gln Val Trp Cys Gln  Phe Gly Glu 
    1070                 1075                 1080             


Asp Arg  Leu Asn Asp Arg Met  Cys Asp Pro Glu Thr  Lys Pro Thr 
    1085                 1090                 1095             


Ser Met  Gln Thr Cys Gln Gln  Pro Glu Cys Ala Ser  Trp Gln Ala 
    1100                 1105                 1110             


Gly Pro  Trp Gly Gln Cys Ser  Val Thr Cys Gly Gln  Gly Tyr Gln 
    1115                 1120                 1125             


Leu Arg  Ala Val Lys Cys Ile  Ile Gly Thr Tyr Met  Ser Val Val 
    1130                 1135                 1140             


Asp Asp  Asn Asp Cys Asn Ala  Ala Thr Arg Pro Thr  Asp Thr Gln 
    1145                 1150                 1155             


Asp Cys  Glu Leu Pro Ser Cys  His Pro Pro Pro Ala  Ala Pro Glu 
    1160                 1165                 1170             


Thr Arg  Arg Ser Thr Tyr Ser  Ala Pro Arg Thr Gln  Trp Arg Phe 
    1175                 1180                 1185             


Gly Ser  Trp Thr Pro Cys Ser  Ala Thr Cys Gly Lys  Gly Thr Arg 
    1190                 1195                 1200             


Met Arg  Tyr Val Ser Cys Arg  Asp Glu Asn Gly Ser  Val Ala Asp 
    1205                 1210                 1215             


Glu Ser  Ala Cys Ala Thr Leu  Pro Arg Pro Val Ala  Lys Glu Glu 
    1220                 1225                 1230             


Cys Ser  Val Thr Pro Cys Gly  Gln Trp Lys Ala Leu  Asp Trp Ser 
    1235                 1240                 1245             


Ser Cys  Ser Val Thr Cys Gly  Gln Gly Arg Ala Thr  Arg Gln Val 
    1250                 1255                 1260             


Met Cys  Val Asn Tyr Ser Asp  His Val Ile Asp Arg  Ser Glu Cys 
    1265                 1270                 1275             


Asp Gln  Asp Tyr Ile Pro Glu  Thr Asp Gln Asp Cys  Ser Met Ser 
    1280                 1285                 1290             


Pro Cys  Pro Gln Arg Thr Pro  Asp Ser Gly Leu Ala  Gln His Pro 
    1295                 1300                 1305             


Phe Gln  Asn Glu Asp Tyr Arg  Pro Arg Ser Ala Ser  Pro Ser Arg 
    1310                 1315                 1320             


Thr His  Val Leu Gly Gly Asn  Gln Trp Arg Thr Gly  Pro Trp Gly 
    1325                 1330                 1335             


Ala Cys  Ser Ser Thr Cys Ala  Gly Gly Ser Gln Arg  Arg Val Val 
    1340                 1345                 1350             


Val Cys  Gln Asp Glu Asn Gly  Tyr Thr Ala Asn Asp  Cys Val Glu 
    1355                 1360                 1365             


Arg Ile  Lys Pro Asp Glu Gln  Arg Ala Cys Glu Ser  Gly Pro Cys 
    1370                 1375                 1380             


Pro Gln  Trp Ala Tyr Gly Asn  Trp Gly Glu Cys Thr  Lys Leu Cys 
    1385                 1390                 1395             


Gly Gly  Gly Ile Arg Thr Arg  Leu Val Val Cys Gln  Arg Ser Asn 
    1400                 1405                 1410             


Gly Glu  Arg Phe Pro Asp Leu  Ser Cys Glu Ile Leu  Asp Lys Pro 
    1415                 1420                 1425             


Pro Asp  Arg Glu Gln Cys Asn  Thr His Ala Cys Pro  His Asp Ala 
    1430                 1435                 1440             


Ala Trp  Ser Thr Gly Pro Trp  Ser Ser Cys Ser Val  Ser Cys Gly 
    1445                 1450                 1455             


Arg Gly  His Lys Gln Arg Asn  Val Tyr Cys Met Ala  Lys Asp Gly 
    1460                 1465                 1470             


Ser His  Leu Glu Ser Asp Tyr  Cys Lys His Leu Ala  Lys Pro His 
    1475                 1480                 1485             


Gly His  Arg Lys Cys Arg Gly  Gly Arg Cys Pro Lys  Trp Lys Ala 
    1490                 1495                 1500             


Gly Ala  Trp Ser Gln Cys Ser  Val Ser Cys Gly Arg  Gly Val Gln 
    1505                 1510                 1515             


Gln Arg  His Val Gly Cys Gln  Ile Gly Thr His Lys  Ile Ala Arg 
    1520                 1525                 1530             


Glu Thr  Glu Cys Asn Pro Tyr  Thr Arg Pro Glu Ser  Glu Arg Asp 
    1535                 1540                 1545             


Cys Gln  Gly Pro Arg Cys Pro  Leu Tyr Thr Trp Arg  Ala Glu Glu 
    1550                 1555                 1560             


Trp Gln  Glu Cys Thr Lys Thr  Cys Gly Glu Gly Ser  Arg Tyr Arg 
    1565                 1570                 1575             


Lys Val  Val Cys Val Asp Asp  Asn Lys Asn Glu Val  His Gly Ala 
    1580                 1585                 1590             


Arg Cys  Asp Val Ser Lys Arg  Pro Val Asp Arg Glu  Ser Cys Ser 
    1595                 1600                 1605             


Leu Gln  Pro Cys Glu Tyr Val  Trp Ile Thr Gly Glu  Trp Ser Glu 
    1610                 1615                 1620             


Cys Ser  Val Thr Cys Gly Lys  Gly Tyr Lys Gln Arg  Leu Val Ser 
    1625                 1630                 1635             


Cys Ser  Glu Ile Tyr Thr Gly  Lys Glu Asn Tyr Glu  Tyr Ser Tyr 
    1640                 1645                 1650             


Gln Thr  Thr Ile Asn Cys Pro  Gly Thr Gln Pro Pro  Ser Val His 
    1655                 1660                 1665             


Pro Cys  Tyr Leu Arg Asp Cys  Pro Val Ser Ala Thr  Trp Arg Val 
    1670                 1675                 1680             


Gly Asn  Trp Gly Ser Cys Ser  Val Ser Cys Gly Val  Gly Val Met 
    1685                 1690                 1695             


Gln Arg  Ser Val Gln Cys Leu  Thr Asn Glu Asp Gln  Pro Ser His 
    1700                 1705                 1710             


Leu Cys  His Thr Asp Leu Lys  Pro Glu Glu Arg Lys  Thr Cys Arg 
    1715                 1720                 1725             


Asn Val  Tyr Asn Cys Glu Leu  Pro Gln Asn Cys Lys  Glu Val Lys 
    1730                 1735                 1740             


Arg Leu  Lys Gly Ala Ser Glu  Asp Gly Glu Tyr Phe  Leu Met Ile 
    1745                 1750                 1755             


Arg Gly  Lys Leu Leu Lys Ile  Phe Cys Ala Gly Met  His Ser Asp 
    1760                 1765                 1770             


His Pro  Lys Glu Tyr Val Thr  Leu Val His Gly Asp  Ser Glu Asn 
    1775                 1780                 1785             


Phe Ser  Glu Val Tyr Gly His  Arg Leu His Asn Pro  Thr Glu Cys 
    1790                 1795                 1800             


Pro Tyr  Asn Gly Ser Arg Arg  Asp Asp Cys Gln Cys  Arg Lys Asp 
    1805                 1810                 1815             


Tyr Thr  Ala Ala Gly Phe Ser  Ser Phe Gln Lys Ile  Arg Ile Asp 
    1820                 1825                 1830             


Leu Thr  Ser Met Gln Ile Ile  Thr Thr Asp Leu Gln  Phe Ala Arg 
    1835                 1840                 1845             


Thr Ser  Glu Gly His Pro Val  Pro Phe Ala Thr Ala  Gly Asp Cys 
    1850                 1855                 1860             


Tyr Ser  Ala Ala Lys Cys Pro  Gln Gly Arg Phe Ser  Ile Asn Leu 
    1865                 1870                 1875             


Tyr Gly  Thr Gly Leu Ser Leu  Thr Glu Ser Ala Arg  Trp Ile Ser 
    1880                 1885                 1890             


Gln Gly  Asn Tyr Ala Val Ser  Asp Ile Lys Lys Ser  Pro Asp Gly 
    1895                 1900                 1905             


Thr Arg  Val Val Gly Lys Cys  Gly Gly Tyr Cys Gly  Lys Cys Thr 
    1910                 1915                 1920             


Pro Ser  Ser Gly Thr Gly Leu  Glu Val Arg Val Leu  
    1925                 1930                 1935 


<210>  226
<211>  1762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTSL1__Homo_sapiens__NP_001035362

<400>  226

Met Glu Cys Cys Arg Arg Ala Thr Pro Gly Thr Leu Leu Leu Phe Leu 
1               5                   10                  15      


Ala Phe Leu Leu Leu Ser Ser Arg Thr Ala Arg Ser Glu Glu Asp Arg 
            20                  25                  30          


Asp Gly Leu Trp Asp Ala Trp Gly Pro Trp Ser Glu Cys Ser Arg Thr 
        35                  40                  45              


Cys Gly Gly Gly Ala Ser Tyr Ser Leu Arg Arg Cys Leu Ser Ser Lys 
    50                  55                  60                  


Ser Cys Glu Gly Arg Asn Ile Arg Tyr Arg Thr Cys Ser Asn Val Asp 
65                  70                  75                  80  


Cys Pro Pro Glu Ala Gly Asp Phe Arg Ala Gln Gln Cys Ser Ala His 
                85                  90                  95      


Asn Asp Val Lys His His Gly Gln Phe Tyr Glu Trp Leu Pro Val Ser 
            100                 105                 110         


Asn Asp Pro Asp Asn Pro Cys Ser Leu Lys Cys Gln Ala Lys Gly Thr 
        115                 120                 125             


Thr Leu Val Val Glu Leu Ala Pro Lys Val Leu Asp Gly Thr Arg Cys 
    130                 135                 140                 


Tyr Thr Glu Ser Leu Asp Met Cys Ile Ser Gly Leu Cys Gln Ile Val 
145                 150                 155                 160 


Gly Cys Asp His Gln Leu Gly Ser Thr Val Lys Glu Asp Asn Cys Gly 
                165                 170                 175     


Val Cys Asn Gly Asp Gly Ser Thr Cys Arg Leu Val Arg Gly Gln Tyr 
            180                 185                 190         


Lys Ser Gln Leu Ser Ala Thr Lys Ser Asp Asp Thr Val Val Ala Ile 
        195                 200                 205             


Pro Tyr Gly Ser Arg His Ile Arg Leu Val Leu Lys Gly Pro Asp His 
    210                 215                 220                 


Leu Tyr Leu Glu Thr Lys Thr Leu Gln Gly Thr Lys Gly Glu Asn Ser 
225                 230                 235                 240 


Leu Ser Ser Thr Gly Thr Phe Leu Val Asp Asn Ser Ser Val Asp Phe 
                245                 250                 255     


Gln Lys Phe Pro Asp Lys Glu Ile Leu Arg Met Ala Gly Pro Leu Thr 
            260                 265                 270         


Ala Asp Phe Ile Val Lys Ile Arg Asn Ser Gly Ser Ala Asp Ser Thr 
        275                 280                 285             


Val Gln Phe Ile Phe Tyr Gln Pro Ile Ile His Arg Trp Arg Glu Thr 
    290                 295                 300                 


Asp Phe Phe Pro Cys Ser Ala Thr Cys Gly Gly Gly Tyr Gln Leu Thr 
305                 310                 315                 320 


Ser Ala Glu Cys Tyr Asp Leu Arg Ser Asn Arg Val Val Ala Asp Gln 
                325                 330                 335     


Tyr Cys His Tyr Tyr Pro Glu Asn Ile Lys Pro Lys Pro Lys Leu Gln 
            340                 345                 350         


Glu Cys Asn Leu Asp Pro Cys Pro Ala Ser Asp Gly Tyr Lys Gln Ile 
        355                 360                 365             


Met Pro Tyr Asp Leu Tyr His Pro Leu Pro Arg Trp Glu Ala Thr Pro 
    370                 375                 380                 


Trp Thr Ala Cys Ser Ser Ser Cys Gly Gly Gly Ile Gln Ser Arg Ala 
385                 390                 395                 400 


Val Ser Cys Val Glu Glu Asp Ile Gln Gly His Val Thr Ser Val Glu 
                405                 410                 415     


Glu Trp Lys Cys Met Tyr Thr Pro Lys Met Pro Ile Ala Gln Pro Cys 
            420                 425                 430         


Asn Ile Phe Asp Cys Pro Lys Trp Leu Ala Gln Glu Trp Ser Pro Cys 
        435                 440                 445             


Thr Val Thr Cys Gly Gln Gly Leu Arg Tyr Arg Val Val Leu Cys Ile 
    450                 455                 460                 


Asp His Arg Gly Met His Thr Gly Gly Cys Ser Pro Lys Thr Lys Pro 
465                 470                 475                 480 


His Ile Lys Glu Glu Cys Ile Val Pro Thr Pro Cys Tyr Lys Pro Lys 
                485                 490                 495     


Glu Lys Leu Pro Val Glu Ala Lys Leu Pro Trp Phe Lys Gln Ala Gln 
            500                 505                 510         


Glu Leu Glu Glu Gly Ala Ala Val Ser Glu Glu Pro Ser Phe Ile Pro 
        515                 520                 525             


Glu Ala Trp Ser Ala Cys Thr Val Thr Cys Gly Val Gly Thr Gln Val 
    530                 535                 540                 


Arg Ile Val Arg Cys Gln Val Leu Leu Ser Phe Ser Gln Ser Val Ala 
545                 550                 555                 560 


Asp Leu Pro Ile Asp Glu Cys Glu Gly Pro Lys Pro Ala Ser Gln Arg 
                565                 570                 575     


Ala Cys Tyr Ala Gly Pro Cys Ser Gly Glu Ile Pro Glu Phe Asn Pro 
            580                 585                 590         


Asp Glu Thr Asp Gly Leu Phe Gly Gly Leu Gln Asp Phe Asp Glu Leu 
        595                 600                 605             


Tyr Asp Trp Glu Tyr Glu Gly Phe Thr Lys Cys Ser Glu Ser Cys Gly 
    610                 615                 620                 


Gly Gly Val Gln Glu Ala Val Val Ser Cys Leu Asn Lys Gln Thr Arg 
625                 630                 635                 640 


Glu Pro Ala Glu Glu Asn Leu Cys Val Thr Ser Arg Arg Pro Pro Gln 
                645                 650                 655     


Leu Leu Lys Ser Cys Asn Leu Asp Pro Cys Pro Ala Arg Trp Glu Ile 
            660                 665                 670         


Gly Lys Trp Ser Pro Cys Ser Leu Thr Cys Gly Val Gly Leu Gln Thr 
        675                 680                 685             


Arg Asp Val Phe Cys Ser His Leu Leu Ser Arg Glu Met Asn Glu Thr 
    690                 695                 700                 


Val Ile Leu Ala Asp Glu Leu Cys Arg Gln Pro Lys Pro Ser Thr Val 
705                 710                 715                 720 


Gln Ala Cys Asn Arg Phe Asn Cys Pro Pro Ala Trp Tyr Pro Ala Gln 
                725                 730                 735     


Trp Gln Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Lys Arg Glu 
            740                 745                 750         


Val Leu Cys Lys Gln Arg Met Ala Asp Gly Ser Phe Leu Glu Leu Pro 
        755                 760                 765             


Glu Thr Phe Cys Ser Ala Ser Lys Pro Ala Cys Gln Gln Ala Cys Lys 
    770                 775                 780                 


Lys Asp Asp Cys Pro Ser Glu Trp Leu Leu Ser Asp Trp Thr Glu Cys 
785                 790                 795                 800 


Ser Thr Ser Cys Gly Glu Gly Thr Gln Thr Arg Ser Ala Ile Cys Arg 
                805                 810                 815     


Lys Met Leu Lys Thr Gly Leu Ser Thr Val Val Asn Ser Thr Leu Cys 
            820                 825                 830         


Pro Pro Leu Pro Phe Ser Ser Ser Ile Arg Pro Cys Met Leu Ala Thr 
        835                 840                 845             


Cys Ala Arg Pro Gly Arg Pro Ser Thr Lys His Ser Pro His Ile Ala 
    850                 855                 860                 


Ala Ala Arg Lys Val Tyr Ile Gln Thr Arg Arg Gln Arg Lys Leu His 
865                 870                 875                 880 


Phe Val Val Gly Gly Phe Ala Tyr Leu Leu Pro Lys Thr Ala Val Val 
                885                 890                 895     


Leu Arg Cys Pro Ala Arg Arg Val Arg Lys Pro Leu Ile Thr Trp Glu 
            900                 905                 910         


Lys Asp Gly Gln His Leu Ile Ser Ser Thr His Val Thr Val Ala Pro 
        915                 920                 925             


Phe Gly Tyr Leu Lys Ile His Arg Leu Lys Pro Ser Asp Ala Gly Val 
    930                 935                 940                 


Tyr Thr Cys Ser Ala Gly Pro Ala Arg Glu His Phe Val Ile Lys Leu 
945                 950                 955                 960 


Ile Gly Gly Asn Arg Lys Leu Val Ala Arg Pro Leu Ser Pro Arg Ser 
                965                 970                 975     


Glu Glu Glu Val Leu Ala Gly Arg Lys Gly Gly Pro Lys Glu Ala Leu 
            980                 985                 990         


Gln Thr His Lys His Gln Asn Gly  Ile Phe Ser Asn Gly  Ser Lys Ala 
        995                 1000                 1005             


Glu Lys  Arg Gly Leu Ala Ala  Asn Pro Gly Ser Arg  Tyr Asp Asp 
    1010                 1015                 1020             


Leu Val  Ser Arg Leu Leu Glu  Gln Gly Gly Trp Pro  Gly Glu Leu 
    1025                 1030                 1035             


Leu Ala  Ser Trp Glu Ala Gln  Asp Ser Ala Glu Arg  Asn Thr Thr 
    1040                 1045                 1050             


Ser Glu  Glu Asp Pro Gly Ala  Glu Gln Val Leu Leu  His Leu Pro 
    1055                 1060                 1065             


Phe Thr  Met Val Thr Glu Gln  Arg Arg Leu Asp Asp  Ile Leu Gly 
    1070                 1075                 1080             


Asn Leu  Ser Gln Gln Pro Glu  Glu Leu Arg Asp Leu  Tyr Ser Lys 
    1085                 1090                 1095             


His Leu  Val Ala Gln Leu Ala  Gln Glu Ile Phe Arg  Ser His Leu 
    1100                 1105                 1110             


Glu His  Gln Asp Thr Leu Leu  Lys Pro Ser Glu Arg  Arg Thr Ser 
    1115                 1120                 1125             


Pro Val  Thr Leu Ser Pro His  Lys His Val Ser Gly  Phe Ser Ser 
    1130                 1135                 1140             


Ser Leu  Arg Thr Ser Ser Thr  Gly Asp Ala Gly Gly  Gly Ser Arg 
    1145                 1150                 1155             


Arg Pro  His Arg Lys Pro Thr  Ile Leu Arg Lys Ile  Ser Ala Ala 
    1160                 1165                 1170             


Gln Gln  Leu Ser Ala Ser Glu  Val Val Thr His Leu  Gly Gln Thr 
    1175                 1180                 1185             


Val Ala  Leu Ala Ser Gly Thr  Leu Ser Val Leu Leu  His Cys Glu 
    1190                 1195                 1200             


Ala Ile  Gly His Pro Arg Pro  Thr Ile Ser Trp Ala  Arg Asn Gly 
    1205                 1210                 1215             


Glu Glu  Val Gln Phe Ser Asp  Arg Ile Leu Leu Gln  Pro Asp Asp 
    1220                 1225                 1230             


Ser Leu  Gln Ile Leu Ala Pro  Val Glu Ala Asp Val  Gly Phe Tyr 
    1235                 1240                 1245             


Thr Cys  Asn Ala Thr Asn Ala  Leu Gly Tyr Asp Ser  Val Ser Ile 
    1250                 1255                 1260             


Ala Val  Thr Leu Ala Gly Lys  Pro Leu Val Lys Thr  Ser Arg Met 
    1265                 1270                 1275             


Thr Val  Ile Asn Thr Glu Lys  Pro Ala Val Thr Val  Asp Ile Gly 
    1280                 1285                 1290             


Ser Thr  Ile Lys Thr Val Gln  Gly Val Asn Val Thr  Ile Asn Cys 
    1295                 1300                 1305             


Gln Val  Ala Gly Val Pro Glu  Ala Glu Val Thr Trp  Phe Arg Asn 
    1310                 1315                 1320             


Lys Ser  Lys Leu Gly Ser Pro  His His Leu His Glu  Gly Ser Leu 
    1325                 1330                 1335             


Leu Leu  Thr Asn Val Ser Ser  Ser Asp Gln Gly Leu  Tyr Ser Cys 
    1340                 1345                 1350             


Arg Ala  Ala Asn Leu His Gly  Glu Leu Thr Glu Ser  Thr Gln Leu 
    1355                 1360                 1365             


Leu Ile  Leu Asp Pro Pro Gln  Val Pro Thr Gln Leu  Glu Asp Ile 
    1370                 1375                 1380             


Arg Ala  Leu Leu Ala Ala Thr  Gly Pro Asn Leu Pro  Ser Val Leu 
    1385                 1390                 1395             


Thr Ser  Pro Leu Gly Thr Gln  Leu Val Leu Asp Pro  Gly Asn Ser 
    1400                 1405                 1410             


Ala Leu  Leu Gly Cys Pro Ile  Lys Gly His Pro Val  Pro Asn Ile 
    1415                 1420                 1425             


Thr Trp  Phe His Gly Gly Gln  Pro Ile Val Thr Ala  Thr Gly Leu 
    1430                 1435                 1440             


Thr His  His Ile Leu Ala Ala  Gly Gln Ile Leu Gln  Val Ala Asn 
    1445                 1450                 1455             


Leu Ser  Gly Gly Ser Gln Gly  Glu Phe Ser Cys Leu  Ala Gln Asn 
    1460                 1465                 1470             


Glu Ala  Gly Val Leu Met Gln  Lys Ala Ser Leu Val  Ile Gln Asp 
    1475                 1480                 1485             


Tyr Trp  Trp Ser Val Asp Arg  Leu Ala Thr Cys Ser  Ala Ser Cys 
    1490                 1495                 1500             


Gly Asn  Arg Gly Val Gln Gln  Pro Arg Leu Arg Cys  Leu Leu Asn 
    1505                 1510                 1515             


Ser Thr  Glu Val Asn Pro Ala  His Cys Ala Gly Lys  Val Arg Pro 
    1520                 1525                 1530             


Ala Val  Gln Pro Ile Ala Cys  Asn Arg Arg Asp Cys  Pro Ser Arg 
    1535                 1540                 1545             


Trp Met  Val Thr Ser Trp Ser  Ala Cys Thr Arg Ser  Cys Gly Gly 
    1550                 1555                 1560             


Gly Val  Gln Thr Arg Arg Val  Thr Cys Gln Lys Leu  Lys Ala Ser 
    1565                 1570                 1575             


Gly Ile  Ser Thr Pro Val Ser  Asn Asp Met Cys Thr  Gln Val Ala 
    1580                 1585                 1590             


Lys Arg  Pro Val Asp Thr Gln  Ala Cys Asn Gln Gln  Leu Cys Val 
    1595                 1600                 1605             


Glu Trp  Ala Phe Ser Ser Trp  Gly Gln Cys Asn Gly  Pro Cys Ile 
    1610                 1615                 1620             


Gly Pro  His Leu Ala Val Gln  His Arg Gln Val Phe  Cys Gln Thr 
    1625                 1630                 1635             


Arg Asp  Gly Ile Thr Leu Pro  Ser Glu Gln Cys Ser  Ala Leu Pro 
    1640                 1645                 1650             


Arg Pro  Val Ser Thr Gln Asn  Cys Trp Ser Glu Ala  Cys Ser Val 
    1655                 1660                 1665             


His Trp  Arg Val Ser Leu Trp  Thr Leu Cys Thr Ala  Thr Cys Gly 
    1670                 1675                 1680             


Asn Tyr  Gly Phe Gln Ser Arg  Arg Val Glu Cys Val  His Ala Arg 
    1685                 1690                 1695             


Thr Asn  Lys Ala Val Pro Glu  His Leu Cys Ser Trp  Gly Pro Arg 
    1700                 1705                 1710             


Pro Ala  Asn Trp Gln Arg Cys  Asn Ile Thr Pro Cys  Glu Asn Met 
    1715                 1720                 1725             


Glu Cys  Arg Asp Thr Thr Arg  Tyr Cys Glu Lys Val  Lys Gln Leu 
    1730                 1735                 1740             


Lys Leu  Cys Gln Leu Ser Gln  Phe Lys Ser Arg Cys  Cys Gly Thr 
    1745                 1750                 1755             


Cys Gly  Lys Ala 
    1760         


<210>  227
<211>  951
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTSL2__Homo_sapiens__NP_001138792

<400>  227

Met Asp Gly Arg Trp Gln Cys Ser Cys Trp Ala Trp Phe Leu Leu Val 
1               5                   10                  15      


Leu Ala Val Val Ala Gly Asp Thr Val Ser Thr Gly Ser Thr Asp Asn 
            20                  25                  30          


Ser Pro Thr Ser Asn Ser Leu Glu Gly Gly Thr Asp Ala Thr Ala Phe 
        35                  40                  45              


Trp Trp Gly Glu Trp Thr Lys Trp Thr Ala Cys Ser Arg Ser Cys Gly 
    50                  55                  60                  


Gly Gly Val Thr Ser Gln Glu Arg His Cys Leu Gln Gln Arg Arg Lys 
65                  70                  75                  80  


Ser Val Pro Gly Pro Gly Asn Arg Thr Cys Thr Gly Thr Ser Lys Arg 
                85                  90                  95      


Tyr Gln Leu Cys Arg Val Gln Glu Cys Pro Pro Asp Gly Arg Ser Phe 
            100                 105                 110         


Arg Glu Glu Gln Cys Val Ser Phe Asn Ser His Val Tyr Asn Gly Arg 
        115                 120                 125             


Thr His Gln Trp Lys Pro Leu Tyr Pro Asp Asp Tyr Val His Ile Ser 
    130                 135                 140                 


Ser Lys Pro Cys Asp Leu His Cys Thr Thr Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Leu Met Val Pro Ala Arg Asp Gly Thr Ser Cys Lys Leu Thr Asp Leu 
                165                 170                 175     


Arg Gly Val Cys Val Ser Gly Lys Cys Glu Pro Ile Gly Cys Asp Gly 
            180                 185                 190         


Val Leu Phe Ser Thr His Thr Leu Asp Lys Cys Gly Ile Cys Gln Gly 
        195                 200                 205             


Asp Gly Ser Ser Cys Thr His Val Thr Gly Asn Tyr Arg Lys Gly Asn 
    210                 215                 220                 


Ala His Leu Gly Tyr Ser Leu Val Thr His Ile Pro Ala Gly Ala Arg 
225                 230                 235                 240 


Asp Ile Gln Ile Val Glu Arg Lys Lys Ser Ala Asp Val Leu Ala Leu 
                245                 250                 255     


Ala Asp Glu Ala Gly Tyr Tyr Phe Phe Asn Gly Asn Tyr Lys Val Asp 
            260                 265                 270         


Ser Pro Lys Asn Phe Asn Ile Ala Gly Thr Val Val Lys Tyr Arg Arg 
        275                 280                 285             


Pro Met Asp Val Tyr Glu Thr Gly Ile Glu Tyr Ile Val Ala Gln Gly 
    290                 295                 300                 


Pro Thr Asn Gln Gly Leu Asn Val Met Val Trp Asn Gln Asn Gly Lys 
305                 310                 315                 320 


Ser Pro Ser Ile Thr Phe Glu Tyr Thr Leu Leu Gln Pro Pro His Glu 
                325                 330                 335     


Ser Arg Pro Gln Pro Ile Tyr Tyr Gly Phe Ser Glu Ser Ala Glu Ser 
            340                 345                 350         


Gln Gly Leu Asp Gly Ala Gly Leu Met Gly Phe Val Pro His Asn Gly 
        355                 360                 365             


Ser Leu Tyr Gly Gln Ala Ser Ser Glu Arg Leu Gly Leu Asp Asn Arg 
    370                 375                 380                 


Leu Phe Gly His Pro Gly Leu Asp Met Glu Leu Gly Pro Ser Gln Gly 
385                 390                 395                 400 


Gln Glu Thr Asn Glu Val Cys Glu Gln Ala Gly Gly Gly Ala Cys Glu 
                405                 410                 415     


Gly Pro Pro Arg Gly Lys Gly Phe Arg Asp Arg Asn Val Thr Gly Thr 
            420                 425                 430         


Pro Leu Thr Gly Asp Lys Asp Asp Glu Glu Val Asp Thr His Phe Ala 
        435                 440                 445             


Ser Gln Glu Phe Phe Ser Ala Asn Ala Ile Ser Asp Gln Leu Leu Gly 
    450                 455                 460                 


Ala Gly Ser Asp Leu Lys Asp Phe Thr Leu Asn Glu Thr Val Asn Ser 
465                 470                 475                 480 


Ile Phe Ala Gln Gly Ala Pro Arg Ser Ser Leu Ala Glu Ser Phe Phe 
                485                 490                 495     


Val Asp Tyr Glu Glu Asn Glu Gly Ala Gly Pro Tyr Leu Leu Asn Gly 
            500                 505                 510         


Ser Tyr Leu Glu Leu Ser Ser Asp Arg Val Ala Asn Ser Ser Ser Glu 
        515                 520                 525             


Ala Pro Phe Pro Asn Val Ser Thr Ser Leu Leu Thr Ser Ala Gly Asn 
    530                 535                 540                 


Arg Thr His Lys Ala Arg Thr Arg Pro Lys Ala Arg Lys Gln Gly Val 
545                 550                 555                 560 


Ser Pro Ala Asp Met Tyr Arg Trp Lys Leu Ser Ser His Glu Pro Cys 
                565                 570                 575     


Ser Ala Thr Cys Thr Thr Gly Val Met Ser Ala Tyr Ala Met Cys Val 
            580                 585                 590         


Arg Tyr Asp Gly Val Glu Val Asp Asp Ser Tyr Cys Asp Ala Leu Thr 
        595                 600                 605             


Arg Pro Glu Pro Val His Glu Phe Cys Ala Gly Arg Glu Cys Gln Pro 
    610                 615                 620                 


Arg Trp Glu Thr Ser Ser Trp Ser Glu Cys Ser Arg Thr Cys Gly Glu 
625                 630                 635                 640 


Gly Tyr Gln Phe Arg Val Val Arg Cys Trp Lys Met Leu Ser Pro Gly 
                645                 650                 655     


Phe Asp Ser Ser Val Tyr Ser Asp Leu Cys Glu Ala Ala Glu Ala Val 
            660                 665                 670         


Arg Pro Glu Glu Arg Lys Thr Cys Arg Asn Pro Ala Cys Gly Pro Gln 
        675                 680                 685             


Trp Glu Met Ser Glu Trp Ser Glu Cys Thr Ala Lys Cys Gly Glu Arg 
    690                 695                 700                 


Ser Val Val Thr Arg Asp Ile Arg Cys Ser Glu Asp Glu Lys Leu Cys 
705                 710                 715                 720 


Asp Pro Asn Thr Arg Pro Val Gly Glu Lys Asn Cys Thr Gly Pro Pro 
                725                 730                 735     


Cys Asp Arg Gln Trp Thr Val Ser Asp Trp Gly Pro Cys Ser Gly Ser 
            740                 745                 750         


Cys Gly Gln Gly Arg Thr Ile Arg His Val Tyr Cys Lys Thr Ser Asp 
        755                 760                 765             


Gly Arg Val Val Pro Glu Ser Gln Cys Gln Met Glu Thr Lys Pro Leu 
    770                 775                 780                 


Ala Ile His Pro Cys Gly Asp Lys Asn Cys Pro Ala His Trp Leu Ala 
785                 790                 795                 800 


Gln Asp Trp Glu Arg Cys Asn Thr Thr Cys Gly Arg Gly Val Lys Lys 
                805                 810                 815     


Arg Leu Val Leu Cys Met Glu Leu Ala Asn Gly Lys Pro Gln Thr Arg 
            820                 825                 830         


Ser Gly Pro Glu Cys Gly Leu Ala Lys Lys Pro Pro Glu Glu Ser Thr 
        835                 840                 845             


Cys Phe Glu Arg Pro Cys Phe Lys Trp Tyr Thr Ser Pro Trp Ser Glu 
    850                 855                 860                 


Cys Thr Lys Thr Cys Gly Val Gly Val Arg Met Arg Asp Val Lys Cys 
865                 870                 875                 880 


Tyr Gln Gly Thr Asp Ile Val Arg Gly Cys Asp Pro Leu Val Lys Pro 
                885                 890                 895     


Val Gly Arg Gln Ala Cys Asp Leu Gln Pro Cys Pro Thr Glu Pro Pro 
            900                 905                 910         


Asp Asp Ser Cys Gln Asp Gln Pro Gly Thr Asn Cys Ala Leu Ala Ile 
        915                 920                 925             


Lys Val Asn Leu Cys Gly His Trp Tyr Tyr Ser Lys Ala Cys Cys Arg 
    930                 935                 940                 


Ser Cys Arg Pro Pro His Ser 
945                 950     


<210>  228
<211>  1691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTSL3__Homo_sapiens__NP_997400

<400>  228

Met Ala Ser Trp Thr Ser Pro Trp Trp Val Leu Ile Gly Met Val Phe 
1               5                   10                  15      


Met His Ser Pro Leu Pro Gln Thr Thr Ala Glu Lys Ser Pro Gly Ala 
            20                  25                  30          


Tyr Phe Leu Pro Glu Phe Ala Leu Ser Pro Gln Gly Ser Phe Leu Glu 
        35                  40                  45              


Asp Thr Thr Gly Glu Gln Phe Leu Thr Tyr Arg Tyr Asp Asp Gln Thr 
    50                  55                  60                  


Ser Arg Asn Thr Arg Ser Asp Glu Asp Lys Asp Gly Asn Trp Asp Ala 
65                  70                  75                  80  


Trp Gly Asp Trp Ser Asp Cys Ser Arg Thr Cys Gly Gly Gly Ala Ser 
                85                  90                  95      


Tyr Ser Leu Arg Arg Cys Leu Thr Gly Arg Asn Cys Glu Gly Gln Asn 
            100                 105                 110         


Ile Arg Tyr Lys Thr Cys Ser Asn His Asp Cys Pro Pro Asp Ala Glu 
        115                 120                 125             


Asp Phe Arg Ala Gln Gln Cys Ser Ala Tyr Asn Asp Val Gln Tyr Gln 
    130                 135                 140                 


Gly His Tyr Tyr Glu Trp Leu Pro Arg Tyr Asn Asp Pro Ala Ala Pro 
145                 150                 155                 160 


Cys Ala Leu Lys Cys His Ala Gln Gly Gln Asn Leu Val Val Glu Leu 
                165                 170                 175     


Ala Pro Lys Val Leu Asp Gly Thr Arg Cys Asn Thr Asp Ser Leu Asp 
            180                 185                 190         


Met Cys Ile Ser Gly Ile Cys Gln Ala Val Gly Cys Asp Arg Gln Leu 
        195                 200                 205             


Gly Ser Asn Ala Lys Glu Asp Asn Cys Gly Val Cys Ala Gly Asp Gly 
    210                 215                 220                 


Ser Thr Cys Arg Leu Val Arg Gly Gln Ser Lys Ser His Val Ser Pro 
225                 230                 235                 240 


Glu Lys Arg Glu Glu Asn Val Ile Ala Val Pro Leu Gly Ser Arg Ser 
                245                 250                 255     


Val Arg Ile Thr Val Lys Gly Pro Ala His Leu Phe Ile Glu Ser Lys 
            260                 265                 270         


Thr Leu Gln Gly Ser Lys Gly Glu His Ser Phe Asn Ser Pro Gly Val 
        275                 280                 285             


Phe Leu Val Glu Asn Thr Thr Val Glu Phe Gln Arg Gly Ser Glu Arg 
    290                 295                 300                 


Gln Thr Phe Lys Ile Pro Gly Pro Leu Met Ala Asp Phe Ile Phe Lys 
305                 310                 315                 320 


Thr Arg Tyr Thr Ala Ala Lys Asp Ser Val Val Gln Phe Phe Phe Tyr 
                325                 330                 335     


Gln Pro Ile Ser His Gln Trp Arg Gln Thr Asp Phe Phe Pro Cys Thr 
            340                 345                 350         


Val Thr Cys Gly Gly Gly Tyr Gln Leu Asn Ser Ala Glu Cys Val Asp 
        355                 360                 365             


Ile Arg Leu Lys Arg Val Val Pro Asp His Tyr Cys His Tyr Tyr Pro 
    370                 375                 380                 


Glu Asn Val Lys Pro Lys Pro Lys Leu Lys Glu Cys Ser Met Asp Pro 
385                 390                 395                 400 


Cys Pro Ser Ser Asp Gly Phe Lys Glu Ile Met Pro Tyr Asp His Phe 
                405                 410                 415     


Gln Pro Leu Pro Arg Trp Glu His Asn Pro Trp Thr Ala Cys Ser Val 
            420                 425                 430         


Ser Cys Gly Gly Gly Ile Gln Arg Arg Ser Phe Val Cys Val Glu Glu 
        435                 440                 445             


Ser Met His Gly Glu Ile Leu Gln Val Glu Glu Trp Lys Cys Met Tyr 
    450                 455                 460                 


Ala Pro Lys Pro Lys Val Met Gln Thr Cys Asn Leu Phe Asp Cys Pro 
465                 470                 475                 480 


Lys Trp Ile Ala Met Glu Trp Ser Gln Cys Thr Val Thr Cys Gly Arg 
                485                 490                 495     


Gly Leu Arg Tyr Arg Val Val Leu Cys Ile Asn His Arg Gly Glu His 
            500                 505                 510         


Val Gly Gly Cys Asn Pro Gln Leu Lys Leu His Ile Lys Glu Glu Cys 
        515                 520                 525             


Val Ile Pro Ile Pro Cys Tyr Lys Pro Lys Glu Lys Ser Pro Val Glu 
    530                 535                 540                 


Ala Lys Leu Pro Trp Leu Lys Gln Ala Gln Glu Leu Glu Glu Thr Arg 
545                 550                 555                 560 


Ile Ala Thr Glu Glu Pro Thr Phe Ile Pro Glu Pro Trp Ser Ala Cys 
                565                 570                 575     


Ser Thr Thr Cys Gly Pro Gly Val Gln Val Arg Glu Val Lys Cys Arg 
            580                 585                 590         


Val Leu Leu Thr Phe Thr Gln Thr Glu Thr Glu Leu Pro Glu Glu Glu 
        595                 600                 605             


Cys Glu Gly Pro Lys Leu Pro Thr Glu Arg Pro Cys Leu Leu Glu Ala 
    610                 615                 620                 


Cys Asp Glu Ser Pro Ala Ser Arg Glu Leu Asp Ile Pro Leu Pro Glu 
625                 630                 635                 640 


Asp Ser Glu Thr Thr Tyr Asp Trp Glu Tyr Ala Gly Phe Thr Pro Cys 
                645                 650                 655     


Thr Ala Thr Cys Val Gly Gly His Gln Glu Ala Ile Ala Val Cys Leu 
            660                 665                 670         


His Ile Gln Thr Gln Gln Thr Val Asn Asp Ser Leu Cys Asp Met Val 
        675                 680                 685             


His Arg Pro Pro Ala Met Ser Gln Ala Cys Asn Thr Glu Pro Cys Pro 
    690                 695                 700                 


Pro Arg Trp His Val Gly Ser Trp Gly Pro Cys Ser Ala Thr Cys Gly 
705                 710                 715                 720 


Val Gly Ile Gln Thr Arg Asp Val Tyr Cys Leu His Pro Gly Glu Thr 
                725                 730                 735     


Pro Ala Pro Pro Glu Glu Cys Arg Asp Glu Lys Pro His Ala Leu Gln 
            740                 745                 750         


Ala Cys Asn Gln Phe Asp Cys Pro Pro Gly Trp His Ile Glu Glu Trp 
        755                 760                 765             


Gln Gln Cys Ser Arg Thr Cys Gly Gly Gly Thr Gln Asn Arg Arg Val 
    770                 775                 780                 


Thr Cys Arg Gln Leu Leu Thr Asp Gly Ser Phe Leu Asn Leu Ser Asp 
785                 790                 795                 800 


Glu Leu Cys Gln Gly Pro Lys Ala Ser Ser His Lys Ser Cys Ala Arg 
                805                 810                 815     


Thr Asp Cys Pro Pro His Leu Ala Val Gly Asp Trp Ser Lys Cys Ser 
            820                 825                 830         


Val Ser Cys Gly Val Gly Ile Gln Arg Arg Lys Gln Val Cys Gln Arg 
        835                 840                 845             


Leu Ala Ala Lys Gly Arg Arg Ile Pro Leu Ser Glu Met Met Cys Arg 
    850                 855                 860                 


Asp Leu Pro Gly Leu Pro Leu Val Arg Ser Cys Gln Met Pro Glu Cys 
865                 870                 875                 880 


Ser Lys Ile Lys Ser Glu Met Lys Thr Lys Leu Gly Glu Gln Gly Pro 
                885                 890                 895     


Gln Ile Leu Ser Val Gln Arg Val Tyr Ile Gln Thr Arg Glu Glu Lys 
            900                 905                 910         


Arg Ile Asn Leu Thr Ile Gly Ser Arg Ala Tyr Leu Leu Pro Asn Thr 
        915                 920                 925             


Ser Val Ile Ile Lys Cys Pro Val Arg Arg Phe Gln Lys Ser Leu Ile 
    930                 935                 940                 


Gln Trp Glu Lys Asp Gly Arg Cys Leu Gln Asn Ser Lys Arg Leu Gly 
945                 950                 955                 960 


Ile Thr Lys Ser Gly Ser Leu Lys Ile His Gly Leu Ala Ala Pro Asp 
                965                 970                 975     


Ile Gly Val Tyr Arg Cys Ile Ala Gly Ser Ala Gln Glu Thr Val Val 
            980                 985                 990         


Leu Lys Leu Ile Gly Thr Asp Asn  Arg Leu Ile Ala Arg  Pro Ala Leu 
        995                 1000                 1005             


Arg Glu  Pro Met Arg Glu Tyr  Pro Gly Met Asp His  Ser Glu Ala 
    1010                 1015                 1020             


Asn Ser  Leu Gly Val Thr Trp  His Lys Met Arg Gln  Met Trp Asn 
    1025                 1030                 1035             


Asn Lys  Asn Asp Leu Tyr Leu  Asp Asp Asp His Ile  Ser Asn Gln 
    1040                 1045                 1050             


Pro Phe  Leu Arg Ala Leu Leu  Gly His Cys Ser Asn  Ser Ala Gly 
    1055                 1060                 1065             


Ser Thr  Asn Ser Trp Glu Leu  Lys Asn Lys Gln Phe  Glu Ala Ala 
    1070                 1075                 1080             


Val Lys  Gln Gly Ala Tyr Ser  Met Asp Thr Ala Gln  Phe Asp Glu 
    1085                 1090                 1095             


Leu Ile  Arg Asn Met Ser Gln  Leu Met Glu Thr Gly  Glu Val Ser 
    1100                 1105                 1110             


Asp Asp  Leu Ala Ser Gln Leu  Ile Tyr Gln Leu Val  Ala Glu Leu 
    1115                 1120                 1125             


Ala Lys  Ala Gln Pro Thr His  Met Gln Trp Arg Gly  Ile Gln Glu 
    1130                 1135                 1140             


Glu Thr  Pro Pro Ala Ala Gln  Leu Arg Gly Glu Thr  Gly Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser His Ala Lys  Asn Ser Gly Lys Leu  Thr Phe Lys 
    1160                 1165                 1170             


Pro Lys  Gly Pro Val Leu Met  Arg Gln Ser Gln Pro  Pro Ser Ile 
    1175                 1180                 1185             


Ser Phe  Asn Lys Thr Ile Asn  Ser Arg Ile Gly Asn  Thr Val Tyr 
    1190                 1195                 1200             


Ile Thr  Lys Arg Thr Glu Val  Ile Asn Ile Leu Cys  Asp Leu Ile 
    1205                 1210                 1215             


Thr Pro  Ser Glu Ala Thr Tyr  Thr Trp Thr Lys Asp  Gly Thr Leu 
    1220                 1225                 1230             


Leu Gln  Pro Ser Val Lys Ile  Ile Leu Asp Gly Thr  Gly Lys Ile 
    1235                 1240                 1245             


Gln Ile  Gln Asn Pro Thr Arg  Lys Glu Gln Gly Ile  Tyr Glu Cys 
    1250                 1255                 1260             


Ser Val  Ala Asn His Leu Gly  Ser Asp Val Glu Ser  Ser Ser Val 
    1265                 1270                 1275             


Leu Tyr  Ala Glu Ala Pro Val  Ile Leu Ser Val Glu  Arg Asn Ile 
    1280                 1285                 1290             


Thr Lys  Pro Glu His Asn His  Leu Ser Val Val Val  Gly Gly Ile 
    1295                 1300                 1305             


Val Glu  Ala Ala Leu Gly Ala  Asn Val Thr Ile Arg  Cys Pro Val 
    1310                 1315                 1320             


Lys Gly  Val Pro Gln Pro Asn  Ile Thr Trp Leu Lys  Arg Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Gly Asn Val Ser  Leu Leu Phe Asn Gly  Ser Leu Leu 
    1340                 1345                 1350             


Leu Gln  Asn Val Ser Leu Glu  Asn Glu Gly Thr Tyr  Val Cys Ile 
    1355                 1360                 1365             


Ala Thr  Asn Ala Leu Gly Lys  Ala Val Ala Thr Ser  Val Leu His 
    1370                 1375                 1380             


Leu Leu  Glu Arg Arg Trp Pro  Glu Ser Arg Ile Val  Phe Leu Gln 
    1385                 1390                 1395             


Gly His  Lys Lys Tyr Ile Leu  Gln Ala Thr Asn Thr  Arg Thr Asn 
    1400                 1405                 1410             


Ser Asn  Asp Pro Thr Gly Glu  Pro Pro Pro Gln Glu  Pro Phe Trp 
    1415                 1420                 1425             


Glu Pro  Gly Asn Trp Ser His  Cys Ser Ala Thr Cys  Gly His Leu 
    1430                 1435                 1440             


Gly Ala  Arg Ile Gln Arg Pro  Gln Cys Val Met Ala  Asn Gly Gln 
    1445                 1450                 1455             


Glu Val  Ser Glu Ala Leu Cys  Asp His Leu Gln Lys  Pro Leu Ala 
    1460                 1465                 1470             


Gly Phe  Glu Pro Cys Asn Ile  Arg Asp Cys Pro Ala  Arg Trp Phe 
    1475                 1480                 1485             


Thr Ser  Val Trp Ser Gln Cys  Ser Val Ser Cys Gly  Glu Gly Tyr 
    1490                 1495                 1500             


His Ser  Arg Gln Val Thr Cys  Lys Arg Thr Lys Ala  Asn Gly Thr 
    1505                 1510                 1515             


Val Gln  Val Val Ser Pro Arg  Ala Cys Ala Pro Lys  Asp Arg Pro 
    1520                 1525                 1530             


Leu Gly  Arg Lys Pro Cys Phe  Gly His Pro Cys Val  Gln Trp Glu 
    1535                 1540                 1545             


Pro Gly  Asn Arg Cys Pro Gly  Arg Cys Met Gly Arg  Ala Val Arg 
    1550                 1555                 1560             


Met Gln  Gln Arg His Thr Ala  Cys Gln His Asn Ser  Ser Asp Ser 
    1565                 1570                 1575             


Asn Cys  Asp Asp Arg Lys Arg  Pro Thr Leu Arg Arg  Asn Cys Thr 
    1580                 1585                 1590             


Ser Gly  Ala Cys Asp Val Cys  Trp His Thr Gly Pro  Trp Lys Pro 
    1595                 1600                 1605             


Cys Thr  Ala Ala Cys Gly Arg  Gly Phe Gln Ser Arg  Lys Val Asp 
    1610                 1615                 1620             


Cys Ile  His Thr Arg Ser Cys  Lys Pro Val Ala Lys  Arg His Cys 
    1625                 1630                 1635             


Val Gln  Lys Lys Lys Pro Ile  Ser Trp Arg His Cys  Leu Gly Pro 
    1640                 1645                 1650             


Ser Cys  Asp Arg Asp Cys Thr  Asp Thr Thr His Tyr  Cys Met Phe 
    1655                 1660                 1665             


Val Lys  His Leu Asn Leu Cys  Ser Leu Asp Arg Tyr  Lys Gln Arg 
    1670                 1675                 1680             


Cys Cys  Gln Ser Cys Gln Glu  Gly 
    1685                 1690     


<210>  229
<211>  1130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTSL4__Homo_sapiens__XP_011507946

<400>  229

Met Leu Ala Pro Arg Arg Ala Pro Ser Thr Pro Arg Cys Leu Arg Ser 
1               5                   10                  15      


Phe Cys Asp Gln Ser Ala Pro Ala Ser Pro Trp Gly Ser Arg Gly Gly 
            20                  25                  30          


Ala Met Glu Asn Trp Thr Gly Arg Pro Trp Leu Tyr Leu Leu Leu Leu 
        35                  40                  45              


Leu Ser Leu Pro Gln Leu Cys Leu Asp Gln Glu Val Leu Ser Gly His 
    50                  55                  60                  


Ser Leu Gln Thr Pro Thr Glu Glu Gly Gln Gly Pro Glu Gly Val Trp 
65                  70                  75                  80  


Gly Pro Trp Val Gln Trp Ala Ser Cys Ser Gln Pro Cys Gly Val Gly 
                85                  90                  95      


Val Gln Arg Arg Ser Arg Thr Cys Gln Leu Pro Thr Val Gln Leu His 
            100                 105                 110         


Pro Ser Leu Pro Leu Pro Pro Arg Pro Pro Arg His Pro Glu Ala Leu 
        115                 120                 125             


Leu Pro Arg Gly Gln Gly Pro Arg Pro Gln Thr Ser Pro Glu Thr Leu 
    130                 135                 140                 


Pro Leu Tyr Arg Thr Gln Ser Arg Gly Arg Gly Gly Pro Leu Arg Gly 
145                 150                 155                 160 


Pro Ala Ser His Leu Gly Arg Glu Glu Thr Gln Glu Ile Arg Ala Ala 
                165                 170                 175     


Arg Arg Ser Arg Leu Arg Asp Pro Ile Lys Pro Gly Met Phe Gly Tyr 
            180                 185                 190         


Gly Arg Val Pro Phe Ala Leu Pro Leu His Arg Asn Arg Arg His Pro 
        195                 200                 205             


Arg Ser Pro Pro Arg Ser Glu Leu Ser Leu Ile Ser Ser Arg Gly Glu 
    210                 215                 220                 


Glu Ala Ile Pro Ser Pro Thr Pro Arg Ala Glu Pro Phe Ser Ala Asn 
225                 230                 235                 240 


Gly Ser Pro Gln Thr Glu Leu Pro Pro Thr Glu Leu Ser Val His Thr 
                245                 250                 255     


Pro Ser Pro Gln Ala Glu Pro Leu Ser Pro Glu Thr Ala Gln Thr Glu 
            260                 265                 270         


Val Ala Pro Arg Thr Arg Pro Ala Pro Leu Arg His His Pro Arg Ala 
        275                 280                 285             


Gln Ala Ser Gly Thr Glu Pro Pro Ser Pro Thr His Ser Leu Gly Glu 
    290                 295                 300                 


Gly Gly Phe Phe Arg Ala Ser Pro Gln Pro Arg Arg Pro Ser Ser Gln 
305                 310                 315                 320 


Gly Trp Ala Ser Pro Gln Val Ala Gly Arg Arg Pro Asp Pro Phe Pro 
                325                 330                 335     


Ser Val Pro Arg Gly Arg Gly Gln Gln Gly Gln Gly Pro Trp Gly Thr 
            340                 345                 350         


Gly Gly Thr Pro His Gly Pro Arg Leu Glu Pro Asp Pro Gln His Pro 
        355                 360                 365             


Gly Ala Trp Leu Pro Leu Leu Ser Asn Gly Pro His Ala Ser Ser Leu 
    370                 375                 380                 


Trp Ser Leu Phe Ala Pro Ser Ser Pro Ile Pro Arg Cys Ser Gly Glu 
385                 390                 395                 400 


Ser Glu Gln Leu Arg Ala Cys Ser Gln Ala Pro Cys Pro Pro Glu Gln 
                405                 410                 415     


Pro Asp Pro Arg Ala Leu Gln Cys Ala Ala Phe Asn Ser Gln Glu Phe 
            420                 425                 430         


Met Gly Gln Leu Tyr Gln Trp Glu Pro Phe Thr Glu Ala Pro Leu Leu 
        435                 440                 445             


Pro Leu Arg His Ala Phe Phe Leu Leu Pro Gly Ala Gly Ser Gly Asp 
    450                 455                 460                 


Ser Thr Gly Val Gln Gly Ser Gln Arg Cys Glu Leu Asn Cys Arg Pro 
465                 470                 475                 480 


Arg Gly Phe Arg Phe Tyr Val Arg His Thr Glu Lys Val Gln Asp Gly 
                485                 490                 495     


Thr Leu Cys Gln Pro Gly Ala Pro Asp Ile Cys Val Ala Gly Arg Cys 
            500                 505                 510         


Leu Ser Pro Gly Cys Asp Gly Ile Leu Gly Ser Gly Arg Arg Pro Asp 
        515                 520                 525             


Gly Cys Gly Val Cys Gly Gly Asp Asp Ser Thr Cys Arg Leu Val Ser 
    530                 535                 540                 


Gly Asn Leu Thr Asp Arg Gly Gly Pro Leu Gly Tyr Gln Lys Ile Leu 
545                 550                 555                 560 


Trp Ile Pro Ala Gly Ala Leu Arg Leu Gln Ile Ala Gln Leu Arg Pro 
                565                 570                 575     


Ser Ser Asn Tyr Leu Ala Leu Arg Gly Pro Gly Gly Arg Ser Ile Ile 
            580                 585                 590         


Asn Gly Asn Trp Ala Val Asp Pro Pro Gly Ser Tyr Arg Ala Gly Gly 
        595                 600                 605             


Thr Val Phe Arg Tyr Asn Arg Pro Pro Arg Glu Glu Gly Lys Gly Glu 
    610                 615                 620                 


Ser Leu Ser Ala Glu Gly Pro Thr Thr Gln Pro Val Asp Val Tyr Met 
625                 630                 635                 640 


Ile Phe Gln Glu Glu Asn Pro Gly Val Phe Tyr Gln Tyr Val Ile Ser 
                645                 650                 655     


Ser Pro Pro Pro Ile Leu Glu Asn Pro Thr Pro Glu Pro Pro Val Pro 
            660                 665                 670         


Gln Leu Gln Pro Glu Ile Leu Arg Val Glu Pro Pro Leu Ala Pro Ala 
        675                 680                 685             


Pro Arg Pro Ala Arg Thr Pro Gly Thr Leu Gln Arg Gln Val Arg Ile 
    690                 695                 700                 


Pro Gln Met Pro Ala Pro Pro His Pro Arg Thr Pro Leu Gly Ser Pro 
705                 710                 715                 720 


Ala Ala Tyr Trp Lys Arg Val Gly His Ser Ala Cys Ser Ala Ser Cys 
                725                 730                 735     


Gly Lys Gly Val Trp Arg Pro Ile Phe Leu Cys Ile Ser Arg Glu Ser 
            740                 745                 750         


Gly Glu Glu Leu Asp Glu Arg Ser Cys Ala Ala Gly Ala Arg Pro Pro 
        755                 760                 765             


Ala Ser Pro Glu Pro Cys His Gly Thr Pro Cys Pro Pro Tyr Trp Glu 
    770                 775                 780                 


Ala Gly Glu Trp Thr Ser Cys Ser Arg Ser Cys Gly Pro Gly Thr Gln 
785                 790                 795                 800 


His Arg Gln Leu Gln Cys Arg Gln Glu Phe Gly Gly Gly Gly Ser Ser 
                805                 810                 815     


Val Pro Pro Glu Arg Cys Gly His Leu Pro Arg Pro Asn Ile Thr Gln 
            820                 825                 830         


Ser Cys Gln Leu Arg Leu Cys Gly His Trp Glu Val Gly Ser Pro Trp 
        835                 840                 845             


Ser Gln Cys Ser Val Arg Cys Gly Arg Gly Gln Arg Ser Arg Gln Val 
    850                 855                 860                 


Arg Cys Val Gly Asn Asn Gly Asp Glu Val Ser Glu Gln Glu Cys Ala 
865                 870                 875                 880 


Ser Gly Pro Pro Gln Pro Pro Ser Arg Glu Ala Cys Asp Met Gly Pro 
                885                 890                 895     


Cys Thr Thr Ala Trp Phe His Ser Asp Trp Ser Ser Lys Cys Ser Ala 
            900                 905                 910         


Glu Cys Gly Thr Gly Ile Gln Arg Arg Ser Val Val Cys Leu Gly Ser 
        915                 920                 925             


Gly Ala Ala Leu Gly Pro Gly Gln Gly Glu Ala Gly Ala Gly Thr Gly 
    930                 935                 940                 


Gln Ser Cys Pro Thr Gly Ser Arg Pro Pro Asp Met Arg Ala Cys Ser 
945                 950                 955                 960 


Leu Gly Pro Cys Glu Arg Thr Trp Arg Trp Tyr Thr Gly Pro Trp Gly 
                965                 970                 975     


Glu Cys Ser Ser Glu Cys Gly Ser Gly Thr Gln Arg Arg Asp Ile Ile 
            980                 985                 990         


Cys Val Ser Lys Leu Gly Thr Glu  Phe Asn Val Thr Ser  Pro Ser Asn 
        995                 1000                 1005             


Cys Ser  His Leu Pro Arg Pro  Pro Ala Leu Gln Pro  Cys Gln Gly 
    1010                 1015                 1020             


Gln Ala  Cys Gln Asp Arg Trp  Phe Ser Thr Pro Trp  Ser Pro Cys 
    1025                 1030                 1035             


Ser Arg  Ser Cys Gln Gly Gly  Thr Gln Thr Arg Glu  Val Gln Cys 
    1040                 1045                 1050             


Leu Ser  Thr Asn Gln Thr Leu  Ser Thr Arg Cys Pro  Pro Gln Leu 
    1055                 1060                 1065             


Arg Pro  Ser Arg Lys Arg Pro  Cys Asn Ser Gln Pro  Cys Ser Gln 
    1070                 1075                 1080             


Arg Pro  Asp Asp Gln Cys Lys  Asp Ser Ser Pro His  Cys Pro Leu 
    1085                 1090                 1095             


Val Val  Gln Ala Arg Leu Cys  Val Tyr Pro Tyr Tyr  Thr Ala Thr 
    1100                 1105                 1110             


Cys Cys  Arg Ser Cys Ala His  Val Leu Glu Arg Ser  Pro Gln Asp 
    1115                 1120                 1125             


Pro Ser  
    1130 


<210>  230
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTSL5__Homo_sapiens__NP_998769

<400>  230

Met Asp Ser Ala Pro Leu Phe Pro Arg Pro His Leu Phe Gln Asn Leu 
1               5                   10                  15      


Leu Leu Phe Leu Trp Ala Leu Leu Asn Cys Gly Leu Gly Val Ser Ala 
            20                  25                  30          


Gln Gly Pro Gly Glu Trp Thr Pro Trp Val Ser Trp Thr Arg Cys Ser 
        35                  40                  45              


Ser Ser Cys Gly Arg Gly Val Ser Val Arg Ser Arg Arg Cys Leu Arg 
    50                  55                  60                  


Leu Pro Gly Glu Glu Pro Cys Trp Gly Asp Ser His Glu Tyr Arg Leu 
65                  70                  75                  80  


Cys Gln Leu Pro Asp Cys Pro Pro Gly Ala Val Pro Phe Arg Asp Leu 
                85                  90                  95      


Gln Cys Ala Leu Tyr Asn Gly Arg Pro Val Leu Gly Thr Gln Lys Thr 
            100                 105                 110         


Tyr Gln Trp Val Pro Phe His Gly Ala Pro Asn Gln Cys Asp Leu Asn 
        115                 120                 125             


Cys Leu Ala Glu Gly His Ala Phe Tyr His Ser Phe Gly Arg Val Leu 
    130                 135                 140                 


Asp Gly Thr Ala Cys Ser Pro Gly Ala Gln Gly Val Cys Val Ala Gly 
145                 150                 155                 160 


Arg Cys Leu Ser Ala Gly Cys Asp Gly Leu Leu Gly Ser Gly Ala Leu 
                165                 170                 175     


Glu Asp Arg Cys Gly Arg Cys Gly Gly Ala Asn Asp Ser Cys Leu Phe 
            180                 185                 190         


Val Gln Arg Val Phe Arg Asp Ala Gly Ala Phe Ala Gly Tyr Trp Asn 
        195                 200                 205             


Val Thr Leu Ile Pro Glu Gly Ala Arg His Ile Arg Val Glu His Arg 
    210                 215                 220                 


Ser Arg Asn His Leu Ala Leu Met Gly Gly Asp Gly Arg Tyr Val Leu 
225                 230                 235                 240 


Asn Gly His Trp Val Val Ser Pro Pro Gly Thr Tyr Glu Ala Ala Gly 
                245                 250                 255     


Thr His Val Val Tyr Thr Arg Asp Thr Gly Pro Gln Glu Thr Leu Gln 
            260                 265                 270         


Ala Ala Gly Pro Thr Ser His Asp Leu Leu Leu Gln Val Leu Leu Gln 
        275                 280                 285             


Glu Pro Asn Pro Gly Ile Glu Phe Glu Phe Trp Leu Pro Arg Glu Arg 
    290                 295                 300                 


Tyr Ser Pro Phe Gln Ala Arg Val Gln Ala Leu Gly Trp Pro Leu Arg 
305                 310                 315                 320 


Gln Pro Gln Pro Arg Gly Val Glu Pro Gln Pro Pro Ala Ala Pro Ala 
                325                 330                 335     


Val Thr Pro Ala Gln Thr Pro Thr Leu Ala Pro Asp Pro Cys Pro Pro 
            340                 345                 350         


Cys Pro Asp Thr Arg Gly Arg Ala His Arg Leu Leu His Tyr Cys Gly 
        355                 360                 365             


Ser Asp Phe Val Phe Gln Ala Arg Val Leu Gly His His His Gln Ala 
    370                 375                 380                 


Gln Glu Thr Arg Tyr Glu Val Arg Ile Gln Leu Val Tyr Lys Asn Arg 
385                 390                 395                 400 


Ser Pro Leu Arg Ala Arg Glu Tyr Val Trp Ala Pro Gly His Cys Pro 
                405                 410                 415     


Cys Pro Met Leu Ala Pro His Arg Asp Tyr Leu Met Ala Val Gln Arg 
            420                 425                 430         


Leu Val Ser Pro Asp Gly Thr Gln Asp Gln Leu Leu Leu Pro His Ala 
        435                 440                 445             


Gly Tyr Ala Arg Pro Trp Ser Pro Ala Glu Asp Ser Arg Ile Arg Leu 
    450                 455                 460                 


Thr Ala Arg Arg Cys Pro Gly 
465                 470     


<210>  231
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAP1__Homo_sapiens__NP_001271237

<400>  231

Met Phe Gln Phe Val Phe Ser Arg Val Tyr Cys Ile Asn Pro Ala Arg 
1               5                   10                  15      


Arg Lys Trp Lys Glu Phe Glu Lys Met Leu Gly Cys Ala Glu Glu Gly 
            20                  25                  30          


His Ala Ser Leu Gly Arg Asp Pro Asp Trp Ala Ser Tyr Thr Leu Gly 
        35                  40                  45              


Val Phe Ile Cys Leu Ser Cys Ser Gly Ile His Arg Asn Ile Pro Gln 
    50                  55                  60                  


Val Ser Lys Val Lys Ser Val Arg Leu Asp Ala Trp Glu Glu Ala Gln 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser His Gly Asn Asp Ala Ala Arg Ala Arg Phe 
                85                  90                  95      


Glu Ser Lys Val Pro Ser Phe Tyr Tyr Arg Pro Thr Pro Ser Asp Cys 
            100                 105                 110         


Gln Leu Leu Arg Glu Gln Trp Ile Arg Ala Lys Tyr Glu Arg Gln Glu 
        115                 120                 125             


Phe Ile Tyr Pro Glu Lys Gln Glu Pro Tyr Ser Ala Gly Tyr Arg Glu 
    130                 135                 140                 


Gly Phe Leu Trp Lys Arg Gly Arg Asp Asn Gly Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Lys Phe Val Leu Thr Glu Arg Glu Gly Ala Leu Lys Tyr Phe Asn Arg 
                165                 170                 175     


Asn Asp Ala Lys Glu Pro Lys Ala Val Met Lys Ile Glu His Leu Asn 
            180                 185                 190         


Ala Thr Phe Gln Pro Ala Lys Ile Gly His Pro His Gly Leu Gln Val 
        195                 200                 205             


Thr Tyr Leu Lys Asp Asn Ser Thr Arg Asn Ile Phe Ile Tyr His Glu 
    210                 215                 220                 


Asp Gly Lys Glu Ile Val Asp Trp Phe Asn Ala Leu Arg Ala Ala Arg 
225                 230                 235                 240 


Phe His Tyr Leu Gln Val Ala Phe Pro Gly Ala Ser Asp Ala Asp Leu 
                245                 250                 255     


Val Pro Lys Leu Ser Arg Asn Tyr Leu Lys Glu Gly Tyr Met Glu Lys 
            260                 265                 270         


Thr Gly Pro Lys Gln Thr Glu Gly Phe Arg Lys Arg Trp Phe Thr Met 
        275                 280                 285             


Asp Asp Arg Arg Leu Met Tyr Phe Lys Asp Pro Leu Asp Ala Phe Ala 
    290                 295                 300                 


Arg Gly Glu Val Phe Ile Gly Ser Lys Glu Ser Gly Tyr Thr Val Leu 
305                 310                 315                 320 


His Gly Phe Pro Pro Ser Thr Gln Gly His His Trp Pro His Gly Ile 
                325                 330                 335     


Thr Ile Val Thr Pro Asp Arg Lys Phe Leu Phe Ala Cys Glu Thr Glu 
            340                 345                 350         


Ser Asp Gln Arg Glu Trp Val Ala Ala Phe Gln Lys Ala Val Asp Arg 
        355                 360                 365             


Pro Met Leu Pro Gln Glu Tyr Ala Val Glu Ala His Phe Lys His Lys 
    370                 375                 380                 


Pro 
385 


<210>  232
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAP2__Homo_sapiens__NP_060874

<400>  232

Met Gly Asp Arg Glu Arg Asn Lys Lys Arg Leu Leu Glu Leu Leu Arg 
1               5                   10                  15      


Ala Pro Asp Thr Gly Asn Ala His Cys Ala Asp Cys Gly Ala Ala Asp 
            20                  25                  30          


Pro Asp Trp Ala Ser Tyr Lys Leu Gly Ile Phe Ile Cys Leu Asn Cys 
        35                  40                  45              


Cys Gly Val His Arg Asn Phe Pro Asp Ile Ser Arg Val Lys Ser Val 
    50                  55                  60                  


Arg Leu Asp Phe Trp Asp Asp Ser Ile Val Glu Phe Met Ile His Asn 
65                  70                  75                  80  


Gly Asn Leu Arg Val Lys Ala Lys Phe Glu Ala Arg Val Pro Ala Phe 
                85                  90                  95      


Tyr Tyr Ile Pro Gln Ala Asn Asp Cys Leu Val Leu Lys Glu Gln Trp 
            100                 105                 110         


Ile Arg Ala Lys Tyr Glu Arg Arg Glu Phe Met Ala Asp Gly Glu Thr 
        115                 120                 125             


Ile Ser Leu Pro Gly Asn Arg Glu Gly Phe Leu Trp Lys Arg Gly Arg 
    130                 135                 140                 


Asp Asn Ser Gln Phe Leu Arg Arg Lys Phe Val Leu Leu Ala Arg Glu 
145                 150                 155                 160 


Gly Leu Leu Lys Tyr Phe Thr Lys Glu Gln Gly Lys Ser Pro Lys Ala 
                165                 170                 175     


Val Ile Ser Ile Lys Asp Leu Asn Ala Thr Phe Gln Thr Glu Lys Ile 
            180                 185                 190         


Gly His Pro His Gly Leu Gln Ile Thr Tyr Arg Arg Asp Gly His Thr 
        195                 200                 205             


Arg Asn Leu Phe Val Tyr His Glu Ser Gly Lys Glu Ile Val Asp Trp 
    210                 215                 220                 


Phe Asn Ala Leu Arg Ala Ala Arg Leu Gln Tyr Leu Lys Met Ala Phe 
225                 230                 235                 240 


Pro Glu Leu Pro Glu Ser Glu Leu Val Pro Phe Leu Thr Arg Asn Tyr 
                245                 250                 255     


Leu Lys Gln Gly Phe Met Glu Lys Thr Gly Pro Lys Gln Lys Glu Pro 
            260                 265                 270         


Phe Lys Lys Arg Trp Phe Ala Leu Asp Cys His Glu Arg Arg Leu Leu 
        275                 280                 285             


Tyr Tyr Lys Asn Pro Leu Asp Ala Phe Glu Gln Gly Gln Val Phe Leu 
    290                 295                 300                 


Gly Asn Lys Glu Gln Gly Tyr Glu Ala Tyr Glu Asp Leu Pro Lys Gly 
305                 310                 315                 320 


Ile Arg Gly Asn Arg Trp Lys Ala Gly Leu Thr Ile Val Thr Pro Glu 
                325                 330                 335     


Arg Arg Phe Val Leu Thr Cys Pro Ser Glu Lys Glu Gln Gln Glu Trp 
            340                 345                 350         


Leu Glu Ser Leu Arg Gly Val Leu Ser Ser Pro Leu Thr Pro Leu Asn 
        355                 360                 365             


Arg Leu Thr Ala Ser Thr Glu Ser Gly Arg Ser Ser Arg 
    370                 375                 380     


<210>  233
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADARB1__Homo_sapiens__NP_056649

<400>  233

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His 
465                 470                 475                 480 


Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr 
                485                 490                 495     


Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro 
            500                 505                 510         


Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu 
        515                 520                 525             


Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly 
    530                 535                 540                 


Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile 
545                 550                 555                 560 


Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe 
                565                 570                 575     


Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His 
            580                 585                 590         


Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu 
        595                 600                 605             


Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile 
    610                 615                 620                 


Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val 
625                 630                 635                 640 


Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr 
                645                 650                 655     


Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu 
            660                 665                 670         


Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu 
        675                 680                 685             


Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala 
    690                 695                 700                 


Ala Lys Glu Tyr Gln Ala Ala Lys Val His 
705                 710                 


<210>  234
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADARB2__Homo_sapiens__NP_061172

<400>  234

Met Ala Ser Val Leu Gly Ser Gly Arg Gly Ser Gly Gly Leu Ser Ser 
1               5                   10                  15      


Gln Leu Lys Cys Lys Ser Lys Arg Arg Arg Arg Arg Arg Ser Lys Arg 
            20                  25                  30          


Lys Asp Lys Val Ser Ile Leu Ser Thr Phe Leu Ala Pro Phe Lys His 
        35                  40                  45              


Leu Ser Pro Gly Ile Thr Asn Thr Glu Asp Asp Asp Thr Leu Ser Thr 
    50                  55                  60                  


Ser Ser Ala Glu Val Lys Glu Asn Arg Asn Val Gly Asn Leu Ala Ala 
65                  70                  75                  80  


Arg Pro Pro Pro Ser Gly Asp Arg Ala Arg Gly Gly Ala Pro Gly Ala 
                85                  90                  95      


Lys Arg Lys Arg Pro Leu Glu Glu Gly Asn Gly Gly His Leu Cys Lys 
            100                 105                 110         


Leu Gln Leu Val Trp Lys Lys Leu Ser Trp Ser Val Ala Pro Lys Asn 
        115                 120                 125             


Ala Leu Val Gln Leu His Glu Leu Arg Pro Gly Leu Gln Tyr Arg Thr 
    130                 135                 140                 


Val Ser Gln Thr Gly Pro Val His Ala Pro Val Phe Ala Val Ala Val 
145                 150                 155                 160 


Glu Val Asn Gly Leu Thr Phe Glu Gly Thr Gly Pro Thr Lys Lys Lys 
                165                 170                 175     


Ala Lys Met Arg Ala Ala Glu Leu Ala Leu Arg Ser Phe Val Gln Phe 
            180                 185                 190         


Pro Asn Ala Cys Gln Ala His Leu Ala Met Gly Gly Gly Pro Gly Pro 
        195                 200                 205             


Gly Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu Phe 
    210                 215                 220                 


Gln Glu Phe Glu Pro Pro Ala Pro Arg Pro Gly Leu Ala Gly Gly Arg 
225                 230                 235                 240 


Pro Gly Asp Ala Ala Leu Leu Ser Ala Ala Tyr Gly Arg Arg Arg Leu 
                245                 250                 255     


Leu Cys Arg Ala Leu Asp Leu Val Gly Pro Thr Pro Ala Thr Pro Ala 
            260                 265                 270         


Ala Pro Gly Glu Arg Asn Pro Val Val Leu Leu Asn Arg Leu Arg Ala 
        275                 280                 285             


Gly Leu Arg Tyr Val Cys Leu Ala Glu Pro Ala Glu Arg Arg Ala Arg 
    290                 295                 300                 


Ser Phe Val Met Ala Val Ser Val Asp Gly Arg Thr Phe Glu Gly Ser 
305                 310                 315                 320 


Gly Arg Ser Lys Lys Leu Ala Arg Gly Gln Ala Ala Gln Ala Ala Leu 
                325                 330                 335     


Gln Glu Leu Phe Asp Ile Gln Met Pro Gly His Ala Pro Gly Arg Ala 
            340                 345                 350         


Arg Arg Thr Pro Met Pro Gln Glu Phe Ala Asp Ser Ile Ser Gln Leu 
        355                 360                 365             


Val Thr Gln Lys Phe Arg Glu Val Thr Thr Asp Leu Thr Pro Met His 
    370                 375                 380                 


Ala Arg His Lys Ala Leu Ala Gly Ile Val Met Thr Lys Gly Leu Asp 
385                 390                 395                 400 


Ala Arg Gln Ala Gln Val Val Ala Leu Ser Ser Gly Thr Lys Cys Ile 
                405                 410                 415     


Ser Gly Glu His Leu Ser Asp Gln Gly Leu Val Val Asn Asp Cys His 
            420                 425                 430         


Ala Glu Val Val Ala Arg Arg Ala Phe Leu His Phe Leu Tyr Thr Gln 
        435                 440                 445             


Leu Glu Leu His Leu Ser Lys Arg Arg Glu Asp Ser Glu Arg Ser Ile 
    450                 455                 460                 


Phe Val Arg Leu Lys Glu Gly Gly Tyr Arg Leu Arg Glu Asn Ile Leu 
465                 470                 475                 480 


Phe His Leu Tyr Val Ser Thr Ser Pro Cys Gly Asp Ala Arg Leu His 
                485                 490                 495     


Ser Pro Tyr Glu Ile Thr Thr Asp Leu His Ser Ser Lys His Leu Val 
            500                 505                 510         


Arg Lys Phe Arg Gly His Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly 
        515                 520                 525             


Thr Val Pro Val Arg Gly Pro Ser Ala Val Gln Thr Trp Asp Gly Val 
    530                 535                 540                 


Leu Leu Gly Glu Gln Leu Ile Thr Met Ser Cys Thr Asp Lys Ile Ala 
545                 550                 555                 560 


Arg Trp Asn Val Leu Gly Leu Gln Gly Ala Leu Leu Ser His Phe Val 
                565                 570                 575     


Glu Pro Val Tyr Leu Gln Ser Ile Val Val Gly Ser Leu His His Thr 
            580                 585                 590         


Gly His Leu Ala Arg Val Met Ser His Arg Met Glu Gly Val Gly Gln 
        595                 600                 605             


Leu Pro Ala Ser Tyr Arg His Asn Arg Pro Leu Leu Ser Gly Val Ser 
    610                 615                 620                 


Asp Ala Glu Ala Arg Gln Pro Gly Lys Ser Pro Pro Phe Ser Met Asn 
625                 630                 635                 640 


Trp Val Val Gly Ser Ala Asp Leu Glu Ile Ile Asn Ala Thr Thr Gly 
                645                 650                 655     


Arg Arg Ser Cys Gly Gly Pro Ser Arg Leu Cys Lys His Val Leu Ser 
            660                 665                 670         


Ala Arg Trp Ala Arg Leu Tyr Gly Arg Leu Ser Thr Arg Thr Pro Ser 
        675                 680                 685             


Pro Gly Asp Thr Pro Ser Met Tyr Cys Glu Ala Lys Leu Gly Ala His 
    690                 695                 700                 


Thr Tyr Gln Ser Val Lys Gln Gln Leu Phe Lys Ala Phe Gln Lys Ala 
705                 710                 715                 720 


Gly Leu Gly Thr Trp Val Arg Lys Pro Pro Glu Gln Gln Gln Phe Leu 
                725                 730                 735     


Leu Thr Leu 
            


<210>  235
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAR__Homo_sapiens__NP_001020278

<400>  235

Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Thr 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Thr Glu Lys Glu Ser Glu Lys Thr Ala Glu Ser 
    290                 295                 300                 


Gln Thr Pro Thr Pro Ser Ala Thr Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Thr Thr Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Thr Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Thr Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Thr Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Thr Glu Val 
            500                 505                 510         


Thr Pro Val Thr Gly Ala Ser Leu Arg Arg Thr Met Leu Leu Leu Ser 
        515                 520                 525             


Arg Ser Pro Glu Ala Gln Pro Lys Thr Leu Pro Leu Thr Gly Ser Thr 
    530                 535                 540                 


Phe His Asp Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu 
545                 550                 555                 560 


Thr Asn Ser Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala 
                565                 570                 575     


Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu 
            580                 585                 590         


Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly 
        595                 600                 605             


Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe 
    610                 615                 620                 


Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala 
625                 630                 635                 640 


Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile 
                645                 650                 655     


Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly 
            660                 665                 670         


Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser 
        675                 680                 685             


Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys 
    690                 695                 700                 


Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser 
705                 710                 715                 720 


Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu 
                725                 730                 735     


Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly 
            740                 745                 750         


Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys 
        755                 760                 765             


Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala 
    770                 775                 780                 


Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu 
785                 790                 795                 800 


Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile 
                805                 810                 815     


Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn 
            820                 825                 830         


Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg 
        835                 840                 845             


Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys 
    850                 855                 860                 


Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg 
865                 870                 875                 880 


Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp 
                885                 890                 895     


Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly 
            900                 905                 910         


Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu 
        915                 920                 925             


Cys Pro Val 
    930     


<210>  236
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAT2__Homo_sapiens__NP_001273188

<400>  236

Met Val Tyr Asn Asn Glu Val Val Gly Lys Gly Arg Asn Glu Val Asn 
1               5                   10                  15      


Gln Thr Lys Asn Ala Thr Arg His Ala Glu Met Val Ala Ile Asp Gln 
            20                  25                  30          


Val Leu Asp Trp Cys Arg Gln Ser Gly Lys Ser Pro Ser Glu Val Phe 
        35                  40                  45              


Glu His Thr Val Leu Tyr Val Thr Val Glu Pro Cys Ile Met Cys Ala 
    50                  55                  60                  


Ala Ala Leu Arg Leu Met Lys Ile Pro Leu Val Val Tyr Gly Cys Gln 
65                  70                  75                  80  


Asn Glu Arg Phe Gly Gly Cys Gly Ser Val Leu Asn Ile Ala Ser Ala 
                85                  90                  95      


Asp Leu Pro Asn Thr Gly Arg Pro Phe Gln Cys Ile Pro Gly Tyr Arg 
            100                 105                 110         


Ala Glu Glu Ala Val Glu Met Leu Lys Thr Phe Tyr Lys Gln Glu Asn 
        115                 120                 125             


Pro Asn Ala Pro Lys Ser Lys Val Arg Lys Lys Glu Cys Gln Lys Ser 
    130                 135                 140                 


<210>  237
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAT3__Homo_sapiens__NP_612431

<400>  237

Met Ile Leu Cys Ser Arg Leu Cys Leu Pro Gln Ser Ala Ser Leu Arg 
1               5                   10                  15      


Met Glu Pro Ala Pro Gly Leu Val Glu Gln Pro Lys Cys Leu Glu Ala 
            20                  25                  30          


Gly Ser Pro Glu Pro Glu Pro Ala Pro Trp Gln Ala Leu Pro Val Leu 
        35                  40                  45              


Ser Glu Lys Gln Ser Gly Asp Val Glu Leu Val Leu Ala Tyr Ala Ala 
    50                  55                  60                  


Pro Val Leu Asp Lys Arg Gln Thr Ser Arg Leu Leu Lys Glu Val Ser 
65                  70                  75                  80  


Ala Leu His Pro Leu Pro Ala Gln Pro His Leu Lys Arg Val Arg Pro 
                85                  90                  95      


Ser Arg Asp Ala Gly Ser Pro His Ala Leu Glu Met Leu Leu Cys Leu 
            100                 105                 110         


Ala Gly Pro Ala Ser Gly Pro Arg Ser Leu Ala Glu Leu Leu Pro Arg 
        115                 120                 125             


Pro Ala Val Asp Pro Arg Gly Leu Gly Gln Pro Phe Leu Val Pro Val 
    130                 135                 140                 


Pro Ala Arg Pro Pro Leu Thr Arg Gly Gln Phe Glu Glu Ala Arg Ala 
145                 150                 155                 160 


His Trp Pro Thr Ser Phe His Glu Asp Lys Gln Val Thr Ser Ala Leu 
                165                 170                 175     


Ala Gly Arg Leu Phe Ser Thr Gln Glu Arg Ala Ala Met Gln Ser His 
            180                 185                 190         


Met Glu Arg Ala Val Trp Ala Ala Arg Arg Ala Ala Ala Arg Gly Leu 
        195                 200                 205             


Arg Ala Val Gly Ala Val Val Val Asp Pro Ala Ser Asp Arg Val Leu 
    210                 215                 220                 


Ala Thr Gly His Asp Cys Ser Cys Ala Asp Asn Pro Leu Leu His Ala 
225                 230                 235                 240 


Val Met Val Cys Val Asp Leu Val Ala Arg Gly Gln Gly Arg Gly Thr 
                245                 250                 255     


Tyr Asp Phe Arg Pro Phe Pro Ala Cys Ser Phe Ala Pro Ala Ala Ala 
            260                 265                 270         


Pro Gln Ala Val Arg Ala Gly Ala Val Arg Lys Leu Asp Ala Asp Glu 
        275                 280                 285             


Asp Gly Leu Pro Tyr Leu Cys Thr Gly Tyr Asp Leu Tyr Val Thr Arg 
    290                 295                 300                 


Glu Pro Cys Ala Met Cys Ala Met Ala Leu Val His Ala Arg Ile Leu 
305                 310                 315                 320 


Arg Val Phe Tyr Gly Ala Pro Ser Pro Asp Gly Ala Leu Gly Thr Arg 
                325                 330                 335     


Phe Arg Ile His Ala Arg Pro Asp Leu Asn His Arg Phe Gln Val Phe 
            340                 345                 350         


Arg Gly Val Leu Glu Glu Gln Cys Arg Trp Leu Asp Pro Asp Thr 
        355                 360                 365         


<210>  238
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCK3__Homo_sapiens__NP_064632

<400>  238

Met Ala Ala Ile Leu Gly Asp Thr Ile Met Val Ala Lys Gly Leu Val 
1               5                   10                  15      


Lys Leu Thr Gln Ala Ala Val Glu Thr His Leu Gln His Leu Gly Ile 
            20                  25                  30          


Gly Gly Glu Leu Ile Met Ala Ala Arg Ala Leu Gln Ser Thr Ala Val 
        35                  40                  45              


Glu Gln Ile Gly Met Phe Leu Gly Lys Val Gln Gly Gln Asp Lys His 
    50                  55                  60                  


Glu Glu Tyr Phe Ala Glu Asn Phe Gly Gly Pro Glu Gly Glu Phe His 
65                  70                  75                  80  


Phe Ser Val Pro His Ala Ala Gly Ala Ser Thr Asp Phe Ser Ser Ala 
                85                  90                  95      


Ser Ala Pro Asp Gln Ser Ala Pro Pro Ser Leu Gly His Ala His Ser 
            100                 105                 110         


Glu Gly Pro Ala Pro Ala Tyr Val Ala Ser Gly Pro Phe Arg Glu Ala 
        115                 120                 125             


Gly Phe Pro Gly Gln Ala Ser Ser Pro Leu Gly Arg Ala Asn Gly Arg 
    130                 135                 140                 


Leu Phe Ala Asn Pro Arg Asp Ser Phe Ser Ala Met Gly Phe Gln Arg 
145                 150                 155                 160 


Arg Phe Phe His Gln Asp Gln Ser Pro Val Gly Gly Leu Thr Ala Glu 
                165                 170                 175     


Asp Ile Glu Lys Ala Arg Gln Ala Lys Ala Arg Pro Glu Asn Lys Gln 
            180                 185                 190         


His Lys Gln Thr Leu Ser Glu His Ala Arg Glu Arg Lys Val Pro Val 
        195                 200                 205             


Thr Arg Ile Gly Arg Leu Ala Asn Phe Gly Gly Leu Ala Val Gly Leu 
    210                 215                 220                 


Gly Phe Gly Ala Leu Ala Glu Val Ala Lys Lys Ser Leu Arg Ser Glu 
225                 230                 235                 240 


Asp Pro Ser Gly Lys Lys Ala Val Leu Gly Ser Ser Pro Phe Leu Ser 
                245                 250                 255     


Glu Ala Asn Ala Glu Arg Ile Val Arg Thr Leu Cys Lys Val Arg Gly 
            260                 265                 270         


Ala Ala Leu Lys Leu Gly Gln Met Leu Ser Ile Gln Asp Asp Ala Phe 
        275                 280                 285             


Ile Asn Pro His Leu Ala Lys Ile Phe Glu Arg Val Arg Gln Ser Ala 
    290                 295                 300                 


Asp Phe Met Pro Leu Lys Gln Met Met Lys Thr Leu Asn Asn Asp Leu 
305                 310                 315                 320 


Gly Pro Asn Trp Arg Asp Lys Leu Glu Tyr Phe Glu Glu Arg Pro Phe 
                325                 330                 335     


Ala Ala Ala Ser Ile Gly Gln Val His Leu Ala Arg Met Lys Gly Gly 
            340                 345                 350         


Arg Glu Val Ala Met Lys Ile Gln Tyr Pro Gly Val Ala Gln Ser Ile 
        355                 360                 365             


Asn Ser Asp Val Asn Asn Leu Met Ala Val Leu Asn Met Ser Asn Met 
    370                 375                 380                 


Leu Pro Glu Gly Leu Phe Pro Glu His Leu Ile Asp Val Leu Arg Arg 
385                 390                 395                 400 


Glu Leu Ala Leu Glu Cys Asp Tyr Gln Arg Glu Ala Ala Cys Ala Arg 
                405                 410                 415     


Lys Phe Arg Asp Leu Leu Lys Gly His Pro Phe Phe Tyr Val Pro Glu 
            420                 425                 430         


Ile Val Asp Glu Leu Cys Ser Pro His Val Leu Thr Thr Glu Leu Val 
        435                 440                 445             


Ser Gly Phe Pro Leu Asp Gln Ala Glu Gly Leu Ser Gln Glu Ile Arg 
    450                 455                 460                 


Asn Glu Ile Cys Tyr Asn Ile Leu Val Leu Cys Leu Arg Glu Leu Phe 
465                 470                 475                 480 


Glu Phe His Phe Met Gln Thr Asp Pro Asn Trp Ser Asn Phe Phe Tyr 
                485                 490                 495     


Asp Pro Gln Gln His Lys Val Ala Leu Leu Asp Phe Gly Ala Thr Arg 
            500                 505                 510         


Glu Tyr Asp Arg Ser Phe Thr Asp Leu Tyr Ile Gln Ile Ile Arg Ala 
        515                 520                 525             


Ala Ala Asp Arg Asp Arg Glu Thr Val Arg Ala Lys Ser Ile Glu Met 
    530                 535                 540                 


Lys Phe Leu Thr Gly Tyr Glu Val Lys Val Met Glu Asp Ala His Leu 
545                 550                 555                 560 


Asp Ala Ile Leu Ile Leu Gly Glu Ala Phe Ala Ser Asp Glu Pro Phe 
                565                 570                 575     


Asp Phe Gly Thr Gln Ser Thr Thr Glu Lys Ile His Asn Leu Ile Pro 
            580                 585                 590         


Val Met Leu Arg His Arg Leu Val Pro Pro Pro Glu Glu Thr Tyr Ser 
        595                 600                 605             


Leu His Arg Lys Met Gly Gly Ser Phe Leu Ile Cys Ser Lys Leu Lys 
    610                 615                 620                 


Ala Arg Phe Pro Cys Lys Ala Met Phe Glu Glu Ala Tyr Ser Asn Tyr 
625                 630                 635                 640 


Cys Lys Arg Gln Ala Gln Gln 
                645         


<210>  239
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCK4__Homo_sapiens__NP_001136027

<400>  239

Met Trp Leu Lys Val Gly Gly Leu Leu Arg Gly Thr Gly Gly Gln Leu 
1               5                   10                  15      


Gly Gln Thr Val Gly Trp Pro Cys Gly Ala Leu Gly Pro Gly Pro His 
            20                  25                  30          


Arg Trp Gly Pro Cys Gly Gly Ser Trp Ala Gln Lys Phe Tyr Gln Asp 
        35                  40                  45              


Gly Pro Gly Arg Gly Leu Gly Glu Glu Asp Ile Arg Arg Ala Arg Glu 
    50                  55                  60                  


Ala Arg Pro Arg Lys Thr Pro Arg Pro Gln Leu Ser Asp Arg Ser Arg 
65                  70                  75                  80  


Glu Arg Lys Val Pro Ala Ser Arg Ile Ser Arg Leu Ala Asn Phe Gly 
                85                  90                  95      


Gly Leu Ala Val Gly Leu Gly Leu Gly Val Leu Ala Glu Met Ala Lys 
            100                 105                 110         


Lys Ser Met Pro Gly Gly Arg Leu Gln Ser Asp Asn Ser Phe Ile Ser 
        115                 120                 125             


Pro Gln Leu Gln His Ile Phe Glu Arg Val Arg Gln Ser Ala Asp Phe 
    130                 135                 140                 


Met Pro Arg Trp Gln Met Leu Arg Val Leu Glu Glu Glu Leu Gly Arg 
145                 150                 155                 160 


Asp Trp Gln Ala Lys Val Ala Ser Leu Glu Glu Val Pro Phe Ala Ala 
                165                 170                 175     


Ala Ser Ile Gly Gln Val His Gln Gly Leu Leu Arg Asp Gly Thr Glu 
            180                 185                 190         


Val Ala Val Lys Ile Gln Tyr Pro Gly Ile Ala Gln Ser Ile Gln Ser 
        195                 200                 205             


Asp Val Gln Asn Leu Leu Ala Val Leu Lys Met Ser Ala Ala Leu Pro 
    210                 215                 220                 


Ala Gly Leu Phe Ala Glu Gln Ser Leu Gln Ala Leu Gln Gln Glu Leu 
225                 230                 235                 240 


Ala Trp Glu Cys Asp Tyr Arg Arg Glu Ala Ala Cys Ala Gln Asn Phe 
                245                 250                 255     


Arg Gln Leu Leu Ala Asn Asp Pro Phe Phe Arg Val Pro Ala Val Val 
            260                 265                 270         


Lys Glu Leu Cys Thr Thr Arg Val Leu Gly Met Glu Leu Ala Gly Gly 
        275                 280                 285             


Val Pro Leu Asp Gln Cys Gln Gly Leu Ser Gln Asp Leu Arg Asn Gln 
    290                 295                 300                 


Ile Cys Phe Gln Leu Leu Thr Leu Cys Leu Arg Glu Leu Phe Glu Phe 
305                 310                 315                 320 


Arg Phe Met Gln Thr Asp Pro Asn Trp Ala Asn Phe Leu Tyr Asp Ala 
                325                 330                 335     


Ser Ser His Gln Val Thr Leu Leu Asp Phe Gly Ala Ser Arg Glu Phe 
            340                 345                 350         


Gly Thr Glu Phe Thr Asp His Tyr Ile Glu Val Val Lys Ala Ala Ala 
        355                 360                 365             


Asp Gly Asp Arg Asp Cys Val Leu Gln Lys Ser Arg Asp Leu Lys Phe 
    370                 375                 380                 


Leu Thr Gly Phe Glu Thr Lys Ala Phe Ser Asp Ala His Val Glu Ala 
385                 390                 395                 400 


Val Met Ile Leu Gly Glu Pro Phe Ala Thr Gln Gly Pro Tyr Asp Phe 
                405                 410                 415     


Gly Ser Gly Glu Thr Ala Arg Arg Ile Gln Asp Leu Ile Pro Val Leu 
            420                 425                 430         


Leu Arg His Arg Leu Cys Pro Pro Pro Glu Glu Thr Tyr Ala Leu His 
        435                 440                 445             


Arg Lys Leu Ala Gly Ala Phe Leu Ala Cys Ala His Leu Arg Ala His 
    450                 455                 460                 


Ile Ala Cys Arg Asp Leu Phe Gln Asp Thr Tyr His Arg Tyr Trp Ala 
465                 470                 475                 480 


Ser Arg Gln Pro Asp Ala Ala Thr Ala Gly Ser Leu Pro Thr Lys Gly 
                485                 490                 495     


Asp Ser Trp Val Asp Pro Ser 
            500             


<210>  240
<211>  1457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY10__Homo_sapiens__NP_001161221

<400>  240

Met Leu Val Phe Gly Asp Glu Thr His Ser His Phe Leu Val Ile Gly 
1               5                   10                  15      


Gln Ala Val Asp Asp Val Arg Leu Ala Gln Asn Met Ala Gln Met Asn 
            20                  25                  30          


Asp Val Ile Leu Ser Pro Asn Cys Trp Gln Leu Cys Asp Arg Ser Met 
        35                  40                  45              


Ile Glu Ile Glu Ser Val Pro Asp Gln Arg Ala Val Lys Val Asn Phe 
    50                  55                  60                  


Leu Lys Pro Pro Pro Asn Phe Asn Phe Asp Glu Phe Phe Thr Lys Cys 
65                  70                  75                  80  


Thr Thr Phe Met His Tyr Tyr Pro Ser Gly Glu His Lys Asn Leu Leu 
                85                  90                  95      


Arg Leu Ala Cys Thr Leu Lys Pro Asp Pro Glu Leu Glu Met Ser Leu 
            100                 105                 110         


Gln Lys Tyr Val Met Glu Ser Ile Leu Lys Gln Ile Asp Asn Lys Gln 
        115                 120                 125             


Leu Gln Gly Tyr Leu Ser Glu Leu Arg Pro Val Thr Ile Val Phe Val 
    130                 135                 140                 


Asn Leu Met Phe Glu Asp Gln Asp Lys Ala Glu Glu Ile Gly Pro Ala 
145                 150                 155                 160 


Ile Gln Asp Ala Tyr Met His Ile Thr Ser Val Leu Lys Ile Phe Gln 
                165                 170                 175     


Gly Gln Ile Asn Lys Val Phe Met Phe Asp Lys Gly Cys Ser Phe Leu 
            180                 185                 190         


Cys Val Phe Gly Phe Pro Gly Glu Lys Val Pro Asp Glu Leu Thr His 
        195                 200                 205             


Ala Leu Glu Cys Ala Met Asp Ile Phe Asp Phe Cys Ser Gln Val His 
    210                 215                 220                 


Lys Ile Gln Thr Val Ser Ile Gly Val Ala Ser Gly Ile Val Phe Cys 
225                 230                 235                 240 


Gly Ile Val Gly His Thr Val Arg His Glu Tyr Thr Val Ile Gly Gln 
                245                 250                 255     


Lys Val Asn Leu Ala Ala Arg Met Met Met Tyr Tyr Pro Gly Ile Val 
            260                 265                 270         


Thr Cys Asp Ser Val Thr Tyr Asn Gly Ser Asn Leu Pro Ala Tyr Phe 
        275                 280                 285             


Phe Lys Glu Leu Pro Lys Lys Val Met Lys Gly Val Ala Asp Ser Gly 
    290                 295                 300                 


Pro Leu Tyr Gln Tyr Trp Gly Arg Thr Glu Lys Val Met Phe Gly Met 
305                 310                 315                 320 


Ala Cys Leu Ile Cys Asn Arg Lys Glu Asp Tyr Pro Leu Leu Gly Arg 
                325                 330                 335     


Asn Lys Glu Ile Asn Tyr Phe Met Tyr Thr Met Lys Lys Phe Leu Ile 
            340                 345                 350         


Ser Asn Ser Ser Gln Val Leu Met Tyr Glu Gly Leu Pro Gly Tyr Gly 
        355                 360                 365             


Lys Ser Gln Ile Leu Met Lys Ile Glu Tyr Leu Ala Gln Gly Lys Asn 
    370                 375                 380                 


His Arg Ile Ile Ala Ile Ser Leu Asn Lys Ile Ser Phe His Gln Thr 
385                 390                 395                 400 


Phe Tyr Thr Ile Gln Met Phe Met Ala Asn Val Leu Gly Leu Asp Thr 
                405                 410                 415     


Cys Lys His Tyr Lys Glu Arg Gln Thr Asn Leu Arg Asn Lys Val Met 
            420                 425                 430         


Thr Leu Leu Asp Glu Lys Phe Tyr Cys Leu Leu Asn Asp Ile Phe His 
        435                 440                 445             


Val Gln Phe Pro Ile Ser Arg Glu Ile Ser Arg Met Ser Thr Leu Lys 
    450                 455                 460                 


Lys Gln Lys Gln Leu Glu Ile Leu Phe Met Lys Ile Leu Lys Leu Ile 
465                 470                 475                 480 


Val Lys Glu Glu Arg Ile Ile Phe Ile Ile Asp Glu Ala Gln Phe Val 
                485                 490                 495     


Asp Ser Thr Ser Trp Arg Phe Met Glu Lys Leu Ile Arg Thr Leu Pro 
            500                 505                 510         


Ile Phe Ile Ile Met Ser Leu Cys Pro Phe Val Asn Ile Pro Cys Ala 
        515                 520                 525             


Ala Ala Arg Ala Val Ile Lys Asn Arg Asn Thr Thr Tyr Ile Val Ile 
    530                 535                 540                 


Gly Ala Val Gln Pro Asn Asp Ile Ser Asn Lys Ile Cys Leu Asp Leu 
545                 550                 555                 560 


Asn Val Ser Cys Ile Ser Lys Glu Leu Asp Ser Tyr Leu Gly Glu Gly 
                565                 570                 575     


Ser Cys Gly Ile Pro Phe Tyr Cys Glu Glu Leu Leu Lys Asn Leu Glu 
            580                 585                 590         


His His Glu Val Leu Val Phe Gln Gln Thr Glu Ser Glu Glu Lys Thr 
        595                 600                 605             


Asn Arg Thr Trp Asn Asn Leu Phe Lys Tyr Ser Ile Lys Leu Thr Glu 
    610                 615                 620                 


Lys Leu Asn Met Val Thr Leu His Ser Asp Lys Glu Ser Glu Glu Val 
625                 630                 635                 640 


Cys His Leu Thr Ser Gly Val Arg Leu Lys Asn Leu Ser Pro Pro Thr 
                645                 650                 655     


Ser Leu Lys Glu Ile Ser Leu Ile Gln Leu Asp Ser Met Arg Leu Ser 
            660                 665                 670         


His Gln Met Leu Val Arg Cys Ala Ala Ile Ile Gly Leu Thr Phe Thr 
        675                 680                 685             


Thr Glu Leu Leu Phe Glu Ile Leu Pro Cys Trp Asn Met Lys Met Met 
    690                 695                 700                 


Ile Lys Thr Leu Ala Thr Leu Val Glu Ser Asn Ile Phe Tyr Cys Phe 
705                 710                 715                 720 


Arg Asn Gly Lys Glu Leu Gln Lys Ala Leu Lys Gln Asn Asp Pro Ser 
                725                 730                 735     


Phe Glu Val His Tyr Arg Ser Leu Ser Leu Lys Pro Ser Glu Gly Met 
            740                 745                 750         


Asp His Gly Glu Glu Glu Gln Leu Arg Glu Leu Glu Asn Glu Val Ile 
        755                 760                 765             


Glu Cys His Arg Ile Arg Phe Cys Asn Pro Met Met Gln Lys Thr Ala 
    770                 775                 780                 


Tyr Glu Leu Trp Leu Lys Asp Gln Arg Lys Ala Met His Leu Lys Cys 
785                 790                 795                 800 


Ala Arg Phe Leu Glu Glu Asp Ala His Arg Cys Asp His Cys Arg Gly 
                805                 810                 815     


Arg Asp Phe Ile Pro Tyr His His Phe Thr Val Asn Ile Arg Leu Asn 
            820                 825                 830         


Ala Leu Asp Met Asp Ala Ile Lys Lys Met Ala Met Ser His Gly Phe 
        835                 840                 845             


Lys Thr Glu Glu Lys Leu Ile Leu Ser Asn Ser Glu Ile Pro Glu Thr 
    850                 855                 860                 


Ser Ala Phe Phe Pro Glu Asn Arg Ser Pro Glu Glu Ile Arg Glu Lys 
865                 870                 875                 880 


Ile Leu Asn Phe Phe Asp His Val Leu Thr Lys Met Lys Thr Ser Asp 
                885                 890                 895     


Glu Asp Ile Ile Pro Leu Glu Ser Cys Gln Cys Glu Glu Ile Leu Glu 
            900                 905                 910         


Ile Val Ile Leu Pro Leu Ala His His Phe Leu Ala Leu Gly Glu Asn 
        915                 920                 925             


Asp Lys Ala Leu Tyr Tyr Phe Leu Glu Ile Ala Ser Ala Tyr Leu Ile 
    930                 935                 940                 


Phe Cys Asp Asn Tyr Met Ala Tyr Met Tyr Leu Asn Glu Gly Gln Lys 
945                 950                 955                 960 


Leu Leu Lys Thr Leu Lys Lys Asp Lys Ser Trp Ser Gln Thr Phe Glu 
                965                 970                 975     


Ser Ala Thr Phe Tyr Ser Leu Lys Gly Glu Val Cys Phe Asn Met Gly 
            980                 985                 990         


Gln Ile Val Leu Ala Lys Lys Met  Leu Arg Lys Ala Leu  Lys Leu Leu 
        995                 1000                 1005             


Asn Arg  Ile Phe Pro Tyr Asn  Leu Ile Ser Leu Phe  Leu His Ile 
    1010                 1015                 1020             


His Val  Glu Lys Asn Arg His  Phe His Tyr Val Asn  Arg Gln Ala 
    1025                 1030                 1035             


Gln Glu  Ser Pro Pro Pro Gly  Lys Lys Arg Leu Ala  Gln Leu Tyr 
    1040                 1045                 1050             


Arg Gln  Thr Val Cys Leu Ser  Leu Leu Trp Arg Ile  Tyr Ser Tyr 
    1055                 1060                 1065             


Ser Tyr  Leu Phe His Cys Lys  Tyr Tyr Ala His Leu  Ala Val Met 
    1070                 1075                 1080             


Met Gln  Met Asn Thr Ala Leu  Glu Thr Gln Asn Cys  Phe Gln Ile 
    1085                 1090                 1095             


Ile Lys  Ala Tyr Leu Asp Tyr  Ser Leu Tyr His His  Leu Ala Gly 
    1100                 1105                 1110             


Tyr Lys  Gly Val Trp Phe Lys  Tyr Glu Val Met Ala  Met Glu His 
    1115                 1120                 1125             


Ile Phe  Asn Leu Pro Leu Lys  Gly Glu Gly Ile Glu  Ile Val Ala 
    1130                 1135                 1140             


Tyr Val  Ala Glu Thr Leu Val  Phe Asn Lys Leu Ile  Met Gly His 
    1145                 1150                 1155             


Leu Asp  Leu Ala Ile Glu Leu  Gly Ser Arg Ala Leu  Gln Met Trp 
    1160                 1165                 1170             


Ala Leu  Leu Gln Asn Pro Asn  Arg His Tyr Gln Ser  Leu Cys Arg 
    1175                 1180                 1185             


Leu Ser  Arg Cys Leu Leu Leu  Asn Ser Arg Tyr Pro  Gln Leu Ile 
    1190                 1195                 1200             


Gln Val  Leu Gly Arg Leu Trp  Glu Leu Ser Val Thr  Gln Glu His 
    1205                 1210                 1215             


Ile Phe  Ser Lys Ala Phe Phe  Tyr Phe Val Cys Leu  Asp Ile Leu 
    1220                 1225                 1230             


Leu Tyr  Ser Gly Phe Val Tyr  Arg Thr Phe Glu Glu  Cys Leu Glu 
    1235                 1240                 1245             


Phe Ile  His Gln Tyr Glu Asn  Asn Arg Ile Leu Lys  Phe His Ser 
    1250                 1255                 1260             


Gly Leu  Leu Leu Gly Leu Tyr  Ser Ser Val Ala Ile  Trp Tyr Ala 
    1265                 1270                 1275             


Arg Leu  Gln Glu Trp Asp Asn  Phe Tyr Lys Phe Ser  Asn Arg Ala 
    1280                 1285                 1290             


Lys Asn  Leu Leu Pro Arg Arg  Thr Met Thr Leu Thr  Tyr Tyr Asp 
    1295                 1300                 1305             


Gly Ile  Ser Arg Tyr Met Glu  Gly Gln Val Leu His  Leu Gln Lys 
    1310                 1315                 1320             


Gln Ile  Lys Glu Gln Ser Glu  Asn Ala Gln Ala Ser  Gly Glu Glu 
    1325                 1330                 1335             


Leu Leu  Lys Asn Leu Glu Asn  Leu Val Ala Gln Asn  Thr Thr Gly 
    1340                 1345                 1350             


Pro Val  Phe Cys Pro Arg Leu  Tyr His Leu Met Ala  Tyr Val Cys 
    1355                 1360                 1365             


Ile Leu  Met Gly Asp Gly Gln  Lys Cys Gly Leu Phe  Leu Asn Thr 
    1370                 1375                 1380             


Ala Leu  Arg Leu Ser Glu Thr  Gln Gly Asn Ile Leu  Glu Lys Cys 
    1385                 1390                 1395             


Trp Leu  Asn Met Asn Lys Glu  Ser Trp Tyr Ser Thr  Ser Glu Leu 
    1400                 1405                 1410             


Lys Glu  Asp Gln Trp Leu Gln  Thr Ile Leu Ser Leu  Pro Ser Trp 
    1415                 1420                 1425             


Glu Lys  Ile Val Ala Gly Arg  Val Asn Ile Gln Asp  Leu Gln Lys 
    1430                 1435                 1440             


Asn Lys  Phe Leu Met Arg Ala  Asn Thr Val Asp Asn  His Phe 
    1445                 1450                 1455         


<210>  241
<211>  1119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY1__Homo_sapiens__NP_066939

<400>  241

Met Ala Gly Ala Pro Arg Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Glu Pro Gly Gly Ala Glu Arg Ala Ala Gly Thr Ser Arg Arg Arg Gly 
            20                  25                  30          


Leu Arg Ala Cys Asp Glu Glu Phe Ala Cys Pro Glu Leu Glu Ala Leu 
        35                  40                  45              


Phe Arg Gly Tyr Thr Leu Arg Leu Glu Gln Ala Ala Thr Leu Lys Ala 
    50                  55                  60                  


Leu Ala Val Leu Ser Leu Leu Ala Gly Ala Leu Ala Leu Ala Glu Leu 
65                  70                  75                  80  


Leu Gly Ala Pro Gly Pro Ala Pro Gly Leu Ala Lys Gly Ser His Pro 
                85                  90                  95      


Val His Cys Val Leu Phe Leu Ala Leu Leu Val Val Thr Asn Val Arg 
            100                 105                 110         


Ser Leu Gln Val Pro Gln Leu Gln Gln Val Gly Gln Leu Ala Leu Leu 
        115                 120                 125             


Phe Ser Leu Thr Phe Ala Leu Leu Cys Cys Pro Phe Ala Leu Gly Gly 
    130                 135                 140                 


Pro Ala Arg Gly Ser Ala Gly Ala Ala Gly Gly Pro Ala Thr Ala Glu 
145                 150                 155                 160 


Gln Gly Val Trp Gln Leu Leu Leu Val Thr Phe Val Ser Tyr Ala Leu 
                165                 170                 175     


Leu Pro Val Arg Ser Leu Leu Ala Ile Gly Phe Gly Leu Val Val Ala 
            180                 185                 190         


Ala Ser His Leu Leu Val Thr Ala Thr Leu Val Pro Ala Lys Arg Pro 
        195                 200                 205             


Arg Leu Trp Arg Thr Leu Gly Ala Asn Ala Leu Leu Phe Val Gly Val 
    210                 215                 220                 


Asn Met Tyr Gly Val Phe Val Arg Ile Leu Thr Glu Arg Ser Gln Arg 
225                 230                 235                 240 


Lys Ala Phe Leu Gln Ala Arg Ser Cys Ile Glu Asp Arg Leu Arg Leu 
                245                 250                 255     


Glu Asp Glu Asn Glu Lys Gln Glu Arg Leu Leu Met Ser Leu Leu Pro 
            260                 265                 270         


Arg Asn Val Ala Met Glu Met Lys Glu Asp Phe Leu Lys Pro Pro Glu 
        275                 280                 285             


Arg Ile Phe His Lys Ile Tyr Ile Gln Arg His Asp Asn Val Ser Ile 
    290                 295                 300                 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gly Leu Ala Ser Gln Cys Thr 
305                 310                 315                 320 


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Gly Lys Phe Asp 
                325                 330                 335     


Glu Leu Ala Thr Glu Asn His Cys Arg Arg Ile Lys Ile Leu Gly Asp 
            340                 345                 350         


Cys Tyr Tyr Cys Val Ser Gly Leu Thr Gln Pro Lys Thr Asp His Ala 
        355                 360                 365             


His Cys Cys Val Glu Met Gly Leu Asp Met Ile Asp Thr Ile Thr Ser 
    370                 375                 380                 


Val Ala Glu Ala Thr Glu Val Asp Leu Asn Met Arg Val Gly Leu His 
385                 390                 395                 400 


Thr Gly Arg Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Tyr 
                405                 410                 415     


Asp Val Trp Ser Asn Asp Val Thr Leu Ala Asn Val Met Glu Ala Ala 
            420                 425                 430         


Gly Leu Pro Gly Lys Val His Ile Thr Lys Thr Thr Leu Ala Cys Leu 
        435                 440                 445             


Asn Gly Asp Tyr Glu Val Glu Pro Gly Tyr Gly His Glu Arg Asn Ser 
    450                 455                 460                 


Phe Leu Lys Thr His Asn Ile Glu Thr Phe Phe Ile Val Pro Ser His 
465                 470                 475                 480 


Arg Arg Lys Ile Phe Pro Gly Leu Ile Leu Ser Asp Ile Lys Pro Ala 
                485                 490                 495     


Lys Arg Met Lys Phe Lys Thr Val Cys Tyr Leu Leu Val Gln Leu Met 
            500                 505                 510         


His Cys Arg Lys Met Phe Lys Ala Glu Ile Pro Phe Ser Asn Val Met 
        515                 520                 525             


Thr Cys Glu Asp Asp Asp Lys Arg Arg Ala Leu Arg Thr Ala Ser Glu 
    530                 535                 540                 


Lys Leu Arg Asn Arg Ser Ser Phe Ser Thr Asn Val Val Tyr Thr Thr 
545                 550                 555                 560 


Pro Gly Thr Arg Val Asn Arg Tyr Ile Ser Arg Leu Leu Glu Ala Arg 
                565                 570                 575     


Gln Thr Glu Leu Glu Met Ala Asp Leu Asn Phe Phe Thr Leu Lys Tyr 
            580                 585                 590         


Lys His Val Glu Arg Glu Gln Lys Tyr His Gln Leu Gln Asp Glu Tyr 
        595                 600                 605             


Phe Thr Ser Ala Val Val Leu Thr Leu Ile Leu Ala Ala Leu Phe Gly 
    610                 615                 620                 


Leu Val Tyr Leu Leu Ile Phe Pro Gln Ser Val Val Val Leu Leu Leu 
625                 630                 635                 640 


Leu Val Phe Cys Ile Cys Phe Leu Val Ala Cys Val Leu Tyr Leu His 
                645                 650                 655     


Ile Thr Arg Val Gln Cys Phe Pro Gly Cys Leu Thr Ile Gln Ile Arg 
            660                 665                 670         


Thr Val Leu Cys Ile Phe Ile Val Val Leu Ile Tyr Ser Val Ala Gln 
        675                 680                 685             


Gly Cys Val Val Gly Cys Leu Pro Trp Ala Trp Ser Ser Lys Pro Asn 
    690                 695                 700                 


Ser Ser Leu Val Val Leu Ser Ser Gly Gly Gln Arg Thr Ala Leu Pro 
705                 710                 715                 720 


Thr Leu Pro Cys Glu Ser Thr His His Ala Leu Leu Cys Cys Leu Val 
                725                 730                 735     


Gly Thr Leu Pro Leu Ala Ile Phe Phe Arg Val Ser Ser Leu Pro Lys 
            740                 745                 750         


Met Ile Leu Leu Ser Gly Leu Thr Thr Ser Tyr Ile Leu Val Leu Glu 
        755                 760                 765             


Leu Ser Gly Tyr Thr Arg Thr Gly Gly Gly Ala Val Ser Gly Arg Ser 
    770                 775                 780                 


Tyr Glu Pro Ile Val Ala Ile Leu Leu Phe Ser Cys Ala Leu Ala Leu 
785                 790                 795                 800 


His Ala Arg Gln Val Asp Ile Arg Leu Arg Leu Asp Tyr Leu Trp Ala 
                805                 810                 815     


Ala Gln Ala Glu Glu Glu Arg Glu Asp Met Glu Lys Val Lys Leu Asp 
            820                 825                 830         


Asn Arg Arg Ile Leu Phe Asn Leu Leu Pro Ala His Val Ala Gln His 
        835                 840                 845             


Phe Leu Met Ser Asn Pro Arg Asn Met Asp Leu Tyr Tyr Gln Ser Tyr 
    850                 855                 860                 


Ser Gln Val Gly Val Met Phe Ala Ser Ile Pro Asn Phe Asn Asp Phe 
865                 870                 875                 880 


Tyr Ile Glu Leu Asp Gly Asn Asn Met Gly Val Glu Cys Leu Arg Leu 
                885                 890                 895     


Leu Asn Glu Ile Ile Ala Asp Phe Asp Glu Leu Met Glu Lys Asp Phe 
            900                 905                 910         


Tyr Lys Asp Ile Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala 
        915                 920                 925             


Ala Val Gly Leu Ala Pro Thr Ser Gly Thr Lys Ala Lys Lys Ser Ile 
    930                 935                 940                 


Ser Ser His Leu Ser Thr Leu Ala Asp Phe Ala Ile Glu Met Phe Asp 
945                 950                 955                 960 


Val Leu Asp Glu Ile Asn Tyr Gln Ser Tyr Asn Asp Phe Val Leu Arg 
                965                 970                 975     


Val Gly Ile Asn Val Gly Pro Val Val Ala Gly Val Ile Gly Ala Arg 
            980                 985                 990         


Arg Pro Gln Tyr Asp Ile Trp Gly  Asn Thr Val Asn Val  Ala Ser Arg 
        995                 1000                 1005             


Met Asp  Ser Thr Gly Val Gln  Gly Arg Ile Gln Val  Thr Glu Glu 
    1010                 1015                 1020             


Val His  Arg Leu Leu Arg Arg  Cys Pro Tyr His Phe  Val Cys Arg 
    1025                 1030                 1035             


Gly Lys  Val Ser Val Lys Gly  Lys Gly Glu Met Leu  Thr Tyr Phe 
    1040                 1045                 1050             


Leu Glu  Gly Arg Thr Asp Gly  Asn Gly Ser Gln Ile  Arg Ser Leu 
    1055                 1060                 1065             


Gly Leu  Asp Arg Lys Met Cys  Pro Phe Gly Arg Ala  Gly Leu Gln 
    1070                 1075                 1080             


Gly Arg  Arg Pro Pro Val Cys  Pro Met Pro Gly Val  Ser Val Arg 
    1085                 1090                 1095             


Ala Gly  Leu Pro Pro His Ser  Pro Gly Gln Tyr Leu  Pro Ser Ala 
    1100                 1105                 1110             


Ala Ala  Gly Lys Glu Ala 
    1115                 


<210>  242
<211>  1091
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY2__Homo_sapiens__NP_065433

<400>  242

Met Trp Gln Glu Ala Met Arg Arg Arg Arg Tyr Leu Arg Asp Arg Ser 
1               5                   10                  15      


Glu Glu Ala Ala Gly Gly Gly Asp Gly Leu Pro Arg Ser Arg Asp Trp 
            20                  25                  30          


Leu Tyr Glu Ser Tyr Tyr Cys Met Ser Gln Gln His Pro Leu Ile Val 
        35                  40                  45              


Phe Leu Leu Leu Ile Val Met Gly Ser Cys Leu Ala Leu Leu Ala Val 
    50                  55                  60                  


Phe Phe Ala Leu Gly Leu Glu Val Glu Asp His Val Ala Phe Leu Ile 
65                  70                  75                  80  


Thr Val Pro Thr Ala Leu Ala Ile Phe Phe Ala Ile Phe Ile Leu Val 
                85                  90                  95      


Cys Ile Glu Ser Val Phe Lys Lys Leu Leu Arg Leu Phe Ser Leu Val 
            100                 105                 110         


Ile Trp Ile Cys Leu Val Ala Met Gly Tyr Leu Phe Met Cys Phe Gly 
        115                 120                 125             


Gly Thr Val Ser Pro Trp Asp Gln Val Ser Phe Phe Leu Phe Ile Ile 
    130                 135                 140                 


Phe Val Val Tyr Thr Met Leu Pro Phe Asn Met Arg Asp Ala Ile Ile 
145                 150                 155                 160 


Ala Ser Val Leu Thr Ser Ser Ser His Thr Ile Val Leu Ser Val Cys 
                165                 170                 175     


Leu Ser Ala Thr Pro Gly Gly Lys Glu His Leu Val Trp Gln Ile Leu 
            180                 185                 190         


Ala Asn Val Ile Ile Phe Ile Cys Gly Asn Leu Ala Gly Ala Tyr His 
        195                 200                 205             


Lys His Leu Met Glu Leu Ala Leu Gln Gln Thr Tyr Gln Asp Thr Cys 
    210                 215                 220                 


Asn Cys Ile Lys Ser Arg Ile Lys Leu Glu Phe Glu Lys Arg Gln Gln 
225                 230                 235                 240 


Glu Arg Leu Leu Leu Ser Leu Leu Pro Ala His Ile Ala Met Glu Met 
                245                 250                 255     


Lys Ala Glu Ile Ile Gln Arg Leu Gln Gly Pro Lys Ala Gly Gln Met 
            260                 265                 270         


Glu Asn Thr Asn Asn Phe His Asn Leu Tyr Val Lys Arg His Thr Asn 
        275                 280                 285             


Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe Thr Arg Leu Ala Ser 
    290                 295                 300                 


Asp Cys Ser Pro Gly Glu Leu Val His Met Leu Asn Glu Leu Phe Gly 
305                 310                 315                 320 


Lys Phe Asp Gln Ile Ala Lys Glu Asn Glu Cys Met Arg Ile Lys Ile 
                325                 330                 335     


Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Ile Ser Leu Pro 
            340                 345                 350         


Asn His Ala Lys Asn Cys Val Lys Met Gly Leu Asp Met Cys Glu Ala 
        355                 360                 365             


Ile Lys Lys Val Arg Asp Ala Thr Gly Val Asp Ile Asn Met Arg Val 
    370                 375                 380                 


Gly Val His Ser Gly Asn Val Leu Cys Gly Val Ile Gly Leu Gln Lys 
385                 390                 395                 400 


Trp Gln Tyr Asp Val Trp Ser His Asp Val Thr Leu Ala Asn His Met 
                405                 410                 415     


Glu Ala Gly Gly Val Pro Gly Arg Val His Ile Ser Ser Val Thr Leu 
            420                 425                 430         


Glu His Leu Asn Gly Ala Tyr Lys Val Glu Glu Gly Asp Gly Asp Ile 
        435                 440                 445             


Arg Asp Pro Tyr Leu Lys Gln His Leu Val Lys Thr Tyr Phe Val Ile 
    450                 455                 460                 


Asn Pro Lys Gly Glu Arg Arg Ser Pro Gln His Leu Phe Arg Pro Arg 
465                 470                 475                 480 


His Thr Leu Asp Gly Ala Lys Met Arg Ala Ser Val Arg Met Thr Arg 
                485                 490                 495     


Tyr Leu Glu Ser Trp Gly Ala Ala Lys Pro Phe Ala His Leu His His 
            500                 505                 510         


Arg Asp Ser Met Thr Thr Glu Asn Gly Lys Ile Ser Thr Thr Asp Val 
        515                 520                 525             


Pro Met Gly Gln His Asn Phe Gln Asn Arg Thr Leu Arg Thr Lys Ser 
    530                 535                 540                 


Gln Lys Lys Arg Phe Glu Glu Glu Leu Asn Glu Arg Met Ile Gln Ala 
545                 550                 555                 560 


Ile Asp Gly Ile Asn Ala Gln Lys Gln Trp Leu Lys Ser Glu Asp Ile 
                565                 570                 575     


Gln Arg Ile Ser Leu Leu Phe Tyr Asn Lys Val Leu Glu Lys Glu Tyr 
            580                 585                 590         


Arg Ala Thr Ala Leu Pro Ala Phe Lys Tyr Tyr Val Thr Cys Ala Cys 
        595                 600                 605             


Leu Ile Phe Phe Cys Ile Phe Ile Val Gln Ile Leu Val Leu Pro Lys 
    610                 615                 620                 


Thr Ser Val Leu Gly Ile Ser Phe Gly Ala Ala Phe Leu Leu Leu Ala 
625                 630                 635                 640 


Phe Ile Leu Phe Val Cys Phe Ala Gly Gln Leu Leu Gln Cys Ser Lys 
                645                 650                 655     


Lys Ala Ser Pro Leu Leu Met Trp Leu Leu Lys Ser Ser Gly Ile Ile 
            660                 665                 670         


Ala Asn Arg Pro Trp Pro Arg Ile Ser Leu Thr Ile Ile Thr Thr Ala 
        675                 680                 685             


Ile Ile Leu Met Met Ala Val Phe Asn Met Phe Phe Leu Ser Asp Ser 
    690                 695                 700                 


Glu Glu Thr Ile Pro Pro Thr Ala Asn Thr Thr Asn Thr Ser Phe Ser 
705                 710                 715                 720 


Ala Ser Asn Asn Gln Val Ala Ile Leu Arg Ala Gln Asn Leu Phe Phe 
                725                 730                 735     


Leu Pro Tyr Phe Ile Tyr Ser Cys Ile Leu Gly Leu Ile Ser Cys Ser 
            740                 745                 750         


Val Phe Leu Arg Val Asn Tyr Glu Leu Lys Met Leu Ile Met Met Val 
        755                 760                 765             


Ala Leu Val Gly Tyr Asn Thr Ile Leu Leu His Thr His Ala His Val 
    770                 775                 780                 


Leu Gly Asp Tyr Ser Gln Val Leu Phe Glu Arg Pro Gly Ile Trp Lys 
785                 790                 795                 800 


Asp Leu Lys Thr Met Gly Ser Val Ser Leu Ser Ile Phe Phe Ile Thr 
                805                 810                 815     


Leu Leu Val Leu Gly Arg Gln Asn Glu Tyr Tyr Cys Arg Leu Asp Phe 
            820                 825                 830         


Leu Trp Lys Asn Lys Phe Lys Lys Glu Arg Glu Glu Ile Glu Thr Met 
        835                 840                 845             


Glu Asn Leu Asn Arg Val Leu Leu Glu Asn Val Leu Pro Ala His Val 
    850                 855                 860                 


Ala Glu His Phe Leu Ala Arg Ser Leu Lys Asn Glu Glu Leu Tyr His 
865                 870                 875                 880 


Gln Ser Tyr Asp Cys Val Cys Val Met Phe Ala Ser Ile Pro Asp Phe 
                885                 890                 895     


Lys Glu Phe Tyr Thr Glu Ser Asp Val Asn Lys Glu Gly Leu Glu Cys 
            900                 905                 910         


Leu Arg Leu Leu Asn Glu Ile Ile Ala Asp Phe Asp Asp Leu Leu Ser 
        915                 920                 925             


Lys Pro Lys Phe Ser Gly Val Glu Lys Ile Lys Thr Ile Gly Ser Thr 
    930                 935                 940                 


Tyr Met Ala Ala Thr Gly Leu Ser Ala Val Pro Ser Gln Glu His Ser 
945                 950                 955                 960 


Gln Glu Pro Glu Arg Gln Tyr Met His Ile Gly Thr Met Val Glu Phe 
                965                 970                 975     


Ala Phe Ala Leu Val Gly Lys Leu Asp Ala Ile Asn Lys His Ser Phe 
            980                 985                 990         


Asn Asp Phe Lys Leu Arg Val Gly  Ile Asn His Gly Pro  Val Ile Ala 
        995                 1000                 1005             


Gly Val  Ile Gly Ala Gln Lys  Pro Gln Tyr Asp Ile  Trp Gly Asn 
    1010                 1015                 1020             


Thr Val  Asn Val Ala Ser Arg  Met Asp Ser Thr Gly  Val Leu Asp 
    1025                 1030                 1035             


Lys Ile  Gln Val Thr Glu Glu  Thr Ser Leu Val Leu  Gln Thr Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Cys Thr Cys Arg  Gly Ile Ile Asn Val  Lys Gly Lys 
    1055                 1060                 1065             


Gly Asp  Leu Lys Thr Tyr Phe  Val Asn Thr Glu Met  Ser Arg Ser 
    1070                 1075                 1080             


Leu Ser  Gln Ser Asn Val Ala  Ser 
    1085                 1090     


<210>  243
<211>  1144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY3__Homo_sapiens__NP_004027

<400>  243

Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Thr His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Thr Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Thr Tyr Phe Lys Arg Gln Arg His Glu Thr Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Thr Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Thr Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Thr Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Thr Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Thr Leu Val Leu Gly Val Thr 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Thr Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Thr Lys Thr Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Thr Gly Thr Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Thr Asp Val Thr Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Thr Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Thr Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Thr Ala Thr Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Thr Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Thr 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Thr 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Thr Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Thr Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Thr Asn Tyr Val Thr Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Thr Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Thr Trp Ile Asp Arg Thr Arg Trp Ala 
    690                 695                 700                 


Arg Asn Thr Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Thr Gly Pro Ser Asn 
                725                 730                 735     


Ala Thr Ala Gly Met Glu Thr Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Thr Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Thr Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Thr Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Thr Asp Arg 
            820                 825                 830         


Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Thr Val Met Val Phe Leu 
        835                 840                 845             


Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala 
    850                 855                 860                 


Arg Thr Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg 
865                 870                 875                 880 


Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Thr Asn Met Leu 
                885                 890                 895     


Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu 
            900                 905                 910         


Glu Leu Tyr Ser Gln Thr Tyr Asp Glu Ile Gly Val Met Phe Ala Ser 
        915                 920                 925             


Leu Pro Asn Phe Ala Asp Phe Tyr Thr Glu Glu Ser Ile Asn Asn Gly 
    930                 935                 940                 


Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp 
945                 950                 955                 960 


Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Thr Lys Ile Lys Thr 
                965                 970                 975     


Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly Val Thr Pro Asp Val Asn 
            980                 985                 990         


Thr Asn Gly Phe Ala Ser Ser Asn  Lys Glu Asp Lys Ser  Glu Arg Glu 
        995                 1000                 1005             


Arg Trp  Gln His Leu Ala Asp  Leu Ala Asp Phe Ala  Leu Ala Met 
    1010                 1015                 1020             


Lys Asp  Thr Leu Thr Asn Ile  Asn Asn Gln Ser Phe  Asn Asn Phe 
    1025                 1030                 1035             


Met Leu  Arg Ile Gly Met Asn  Lys Gly Gly Val Leu  Ala Gly Val 
    1040                 1045                 1050             


Ile Gly  Ala Arg Lys Pro His  Tyr Asp Ile Trp Gly  Asn Thr Val 
    1055                 1060                 1065             


Asn Val  Ala Ser Arg Met Glu  Ser Thr Gly Val Met  Gly Asn Ile 
    1070                 1075                 1080             


Gln Val  Val Glu Glu Thr Gln  Val Ile Leu Arg Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Arg Phe  Val Arg Arg Gly Pro  Ile Phe Val Lys Gly  Lys Gly Glu 
    1100                 1105                 1110             


Leu Leu  Thr Phe Phe Leu Lys  Gly Arg Asp Lys Leu  Ala Thr Phe 
    1115                 1120                 1125             


Pro Asn  Gly Pro Ser Val Thr  Leu Pro His Gln Val  Val Asp Asn 
    1130                 1135                 1140             


Ser 
    


<210>  244
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY5__Homo_sapiens__NP_001186571

<400>  244

Met Lys Ser Gln Lys Glu Gly Cys Cys Ser Arg Gly Asp Leu Ser Ile 
1               5                   10                  15      


Gln Thr Gly Pro Gly Gly Glu Trp Ala Pro Arg Arg Leu Val Ser Asn 
            20                  25                  30          


Val Leu Ile Phe Ser Cys Thr Asn Ile Val Gly Val Cys Thr His Tyr 
        35                  40                  45              


Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg Glu Cys 
    50                  55                  60                  


Ile Gln Ala Arg Leu His Ser Gln Arg Glu Asn Gln Gln Gln Glu Arg 
65                  70                  75                  80  


Leu Leu Leu Ser Val Leu Pro Arg His Val Ala Met Glu Met Lys Ala 
                85                  90                  95      


Asp Ile Asn Ala Lys Gln Glu Asp Met Met Phe His Lys Ile Tyr Ile 
            100                 105                 110         


Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe 
        115                 120                 125             


Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu Val Met Thr Leu 
    130                 135                 140                 


Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys 
145                 150                 155                 160 


Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                165                 170                 175     


Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met Gly Met 
            180                 185                 190         


Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val Thr Gly Val Asn 
        195                 200                 205             


Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val His Cys Gly Val 
    210                 215                 220                 


Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Thr 
225                 230                 235                 240 


Leu Ala Asn His Met Glu Ala Gly Gly Lys Ala Gly Arg Ile His Ile 
                245                 250                 255     


Thr Lys Ala Thr Leu Asn Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro 
            260                 265                 270         


Gly Cys Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu His Ser Ile Glu 
        275                 280                 285             


Thr Phe Leu Ile Leu Arg Cys Thr Gln Lys Arg Lys Glu Glu Lys Ala 
    290                 295                 300                 


Met Ile Ala Lys Met Asn Arg Gln Arg Thr Asn Ser Ile Gly His Asn 
305                 310                 315                 320 


Pro Pro His Trp Gly Ala Glu Arg Pro Phe Tyr Asn His Leu Gly Gly 
                325                 330                 335     


Asn Gln Val Ser Lys Glu Met Lys Arg Met Gly Phe Glu Asp Pro Lys 
            340                 345                 350         


Asp Lys Asn Ala Gln Glu Ser Ala Asn Pro Glu Asp Glu Val Asp Glu 
        355                 360                 365             


Phe Leu Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Arg Leu Arg Ser 
    370                 375                 380                 


Glu His Val Arg Lys Phe Leu Leu Thr Phe Arg Glu Pro Asp Leu Glu 
385                 390                 395                 400 


Lys Lys Tyr Ser Lys Gln Val Asp Asp Arg Phe Gly Ala Tyr Val Ala 
                405                 410                 415     


Cys Ala Ser Leu Val Phe Leu Phe Ile Cys Phe Val Gln Ile Thr Ile 
            420                 425                 430         


Val Pro His Ser Ile Phe Met Leu Ser Phe Tyr Leu Thr Cys Ser Leu 
        435                 440                 445             


Leu Leu Thr Leu Val Val Phe Val Ser Val Ile Tyr Ser Cys Val Lys 
    450                 455                 460                 


Leu Phe Pro Ser Pro Leu Gln Thr Leu Ser Arg Lys Ile Val Arg Ser 
465                 470                 475                 480 


Lys Met Asn Ser Thr Leu Val Gly Val Phe Thr Ile Thr Leu Val Phe 
                485                 490                 495     


Leu Ala Ala Phe Val Asn Met Phe Thr Cys Asn Ser Arg Asp Leu Leu 
            500                 505                 510         


Gly Cys Leu Ala Gln Glu His Asn Ile Ser Ala Ser Gln Val Asn Ala 
        515                 520                 525             


Cys His Val Ala Glu Ser Ala Val Asn Tyr Ser Leu Gly Asp Glu Gln 
    530                 535                 540                 


Gly Phe Cys Gly Ser Pro Trp Pro Asn Cys Asn Phe Pro Glu Tyr Phe 
545                 550                 555                 560 


Thr Tyr Ser Val Leu Leu Ser Leu Leu Ala Cys Ser Val Phe Leu Gln 
                565                 570                 575     


Ile Ser Cys Ile Gly Lys Leu Val Leu Met Leu Ala Ile Glu Leu Ile 
            580                 585                 590         


Tyr Val Leu Ile Val Glu Val Pro Gly Val Thr Leu Phe Asp Asn Ala 
        595                 600                 605             


Asp Leu Leu Val Thr Ala Asn Ala Ile Asp Phe Phe Asn Asn Gly Thr 
    610                 615                 620                 


Ser Gln Cys Pro Glu His Ala Thr Lys Val Ala Leu Lys Val Val Thr 
625                 630                 635                 640 


Pro Ile Ile Ile Ser Val Phe Val Leu Ala Leu Tyr Leu His Ala Gln 
                645                 650                 655     


Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu Gln Ala 
            660                 665                 670         


Thr Glu Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn Arg Arg 
        675                 680                 685             


Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe Leu Ala 
    690                 695                 700                 


Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu Cys Val 
705                 710                 715                 720 


Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr Val Glu 
                725                 730                 735     


Leu Glu Ala Asn Asn Glu Gly Val Glu Cys Leu Arg Leu Leu Asn Glu 
            740                 745                 750         


Ile Ile Ala Asp Phe Asp Glu Ile Ile Ser Glu Asp Arg Phe Arg Gln 
        755                 760                 765             


Leu Glu Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly 
    770                 775                 780                 


Leu Asn Asp Ser Thr Tyr Asp Lys Val Gly Lys Thr His Ile Lys Ala 
785                 790                 795                 800 


Leu Ala Asp Phe Ala Met Lys Leu Met Asp Gln Met Lys Tyr Ile Asn 
                805                 810                 815     


Glu His Ser Phe Asn Asn Phe Gln Met Lys Ile Gly Leu Asn Ile Gly 
            820                 825                 830         


Pro Val Val Ala Gly Val Ile Gly Ala Arg Lys Pro Gln Tyr Asp Ile 
        835                 840                 845             


Trp Gly Asn Thr Val Asn Val Ala Ser Arg Met Asp Ser Thr Gly Val 
    850                 855                 860                 


Pro Asp Arg Ile Gln Val Thr Thr Asp Met Tyr Gln Val Leu Ala Ala 
865                 870                 875                 880 


Asn Thr Tyr Gln Leu Glu Cys Arg Gly Val Val Lys Val Lys Gly Lys 
                885                 890                 895     


Gly Glu Met Met Thr Tyr Phe Leu Asn Gly Gly Pro Pro Leu Ser 
            900                 905                 910     


<210>  245
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY6__Homo_sapiens__NP_056085

<400>  245

Met Ser Trp Phe Ser Gly Leu Leu Val Pro Lys Val Asp Glu Arg Lys 
1               5                   10                  15      


Thr Ala Trp Gly Glu Arg Asn Gly Gln Lys Arg Ser Arg Arg Arg Gly 
            20                  25                  30          


Thr Arg Ala Gly Gly Phe Cys Thr Pro Arg Tyr Met Ser Cys Leu Arg 
        35                  40                  45              


Asp Ala Glu Pro Pro Ser Pro Thr Pro Ala Gly Pro Pro Arg Cys Pro 
    50                  55                  60                  


Trp Gln Asp Asp Ala Phe Ile Arg Arg Gly Gly Pro Gly Lys Gly Lys 
65                  70                  75                  80  


Glu Leu Gly Leu Arg Ala Val Ala Leu Gly Phe Glu Asp Thr Glu Val 
                85                  90                  95      


Thr Thr Thr Ala Gly Gly Thr Ala Glu Val Ala Pro Asp Ala Val Pro 
            100                 105                 110         


Arg Ser Gly Arg Ser Cys Trp Arg Arg Leu Val Gln Val Phe Gln Ser 
        115                 120                 125             


Lys Gln Phe Arg Ser Ala Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe 
    130                 135                 140                 


Phe Gln Met Asn Gln Ser Ser Leu Thr Leu Leu Met Ala Val Leu Val 
145                 150                 155                 160 


Leu Leu Thr Ala Val Leu Leu Ala Phe His Ala Ala Pro Ala Arg Pro 
                165                 170                 175     


Gln Pro Ala Tyr Val Ala Leu Leu Ala Cys Ala Ala Ala Leu Phe Val 
            180                 185                 190         


Gly Leu Met Val Val Cys Asn Arg His Ser Phe Arg Gln Asp Ser Met 
        195                 200                 205             


Trp Val Val Ser Tyr Val Val Leu Gly Ile Leu Ala Ala Val Gln Val 
    210                 215                 220                 


Gly Gly Ala Leu Ala Ala Asp Pro Arg Ser Pro Ser Ala Gly Leu Trp 
225                 230                 235                 240 


Cys Pro Val Phe Phe Val Tyr Ile Ala Tyr Thr Leu Leu Pro Ile Arg 
                245                 250                 255     


Met Arg Ala Ala Val Leu Ser Gly Leu Gly Leu Ser Thr Leu His Leu 
            260                 265                 270         


Ile Leu Ala Trp Gln Leu Asn Arg Gly Asp Ala Phe Leu Trp Lys Gln 
        275                 280                 285             


Leu Gly Ala Asn Val Leu Leu Phe Leu Cys Thr Asn Val Ile Gly Ile 
    290                 295                 300                 


Cys Thr His Tyr Pro Ala Glu Val Ser Gln Arg Gln Ala Phe Gln Glu 
305                 310                 315                 320 


Thr Arg Gly Tyr Ile Gln Ala Arg Leu His Leu Gln His Glu Asn Arg 
                325                 330                 335     


Gln Gln Glu Arg Leu Leu Leu Ser Val Leu Pro Gln His Val Ala Met 
            340                 345                 350         


Glu Met Lys Glu Asp Ile Asn Thr Lys Lys Glu Asp Met Met Phe His 
        355                 360                 365             


Lys Ile Tyr Ile Gln Lys His Asp Asn Val Ser Ile Leu Phe Ala Asp 
    370                 375                 380                 


Ile Glu Gly Phe Thr Ser Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu 
385                 390                 395                 400 


Val Met Thr Leu Asn Glu Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala 
                405                 410                 415     


Glu Asn His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys 
            420                 425                 430         


Val Ser Gly Leu Pro Glu Ala Arg Ala Asp His Ala His Cys Cys Val 
        435                 440                 445             


Glu Met Gly Val Asp Met Ile Glu Ala Ile Ser Leu Val Arg Glu Val 
    450                 455                 460                 


Thr Gly Val Asn Val Asn Met Arg Val Gly Ile His Ser Gly Arg Val 
465                 470                 475                 480 


His Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp Val Trp Ser 
                485                 490                 495     


Asn Asp Val Thr Leu Ala Asn His Met Glu Ala Gly Gly Arg Ala Gly 
            500                 505                 510         


Arg Ile His Ile Thr Arg Ala Thr Leu Gln Tyr Leu Asn Gly Asp Tyr 
        515                 520                 525             


Glu Val Glu Pro Gly Arg Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu 
    530                 535                 540                 


Gln His Ile Glu Thr Phe Leu Ile Leu Gly Ala Ser Gln Lys Arg Lys 
545                 550                 555                 560 


Glu Glu Lys Ala Met Leu Ala Lys Leu Gln Arg Thr Arg Ala Asn Ser 
                565                 570                 575     


Met Glu Gly Leu Met Pro Arg Trp Val Pro Asp Arg Ala Phe Ser Arg 
            580                 585                 590         


Thr Lys Asp Ser Lys Ala Phe Arg Gln Met Gly Ile Asp Asp Ser Ser 
        595                 600                 605             


Lys Asp Asn Arg Gly Thr Gln Asp Ala Leu Asn Pro Glu Asp Glu Val 
    610                 615                 620                 


Asp Glu Phe Leu Ser Arg Ala Ile Asp Ala Arg Ser Ile Asp Gln Leu 
625                 630                 635                 640 


Arg Lys Asp His Val Arg Arg Phe Leu Leu Thr Phe Gln Arg Glu Asp 
                645                 650                 655     


Leu Glu Lys Lys Tyr Ser Arg Lys Val Asp Pro Arg Phe Gly Ala Tyr 
            660                 665                 670         


Val Ala Cys Ala Leu Leu Val Phe Cys Phe Ile Cys Phe Ile Gln Leu 
        675                 680                 685             


Leu Ile Phe Pro His Ser Thr Leu Met Leu Gly Ile Tyr Ala Ser Ile 
    690                 695                 700                 


Phe Leu Leu Leu Leu Ile Thr Val Leu Ile Cys Ala Val Tyr Ser Cys 
705                 710                 715                 720 


Gly Ser Leu Phe Pro Lys Ala Leu Gln Arg Leu Ser Arg Ser Ile Val 
                725                 730                 735     


Arg Ser Arg Ala His Ser Thr Ala Val Gly Ile Phe Ser Val Leu Leu 
            740                 745                 750         


Val Phe Thr Ser Ala Ile Ala Asn Met Phe Thr Cys Asn His Thr Pro 
        755                 760                 765             


Ile Arg Ser Cys Ala Ala Arg Met Leu Asn Leu Thr Pro Ala Asp Ile 
    770                 775                 780                 


Thr Ala Cys His Leu Gln Gln Leu Asn Tyr Ser Leu Gly Leu Asp Ala 
785                 790                 795                 800 


Pro Leu Cys Glu Gly Thr Met Pro Thr Cys Ser Phe Pro Glu Tyr Phe 
                805                 810                 815     


Ile Gly Asn Met Leu Leu Ser Leu Leu Ala Ser Ser Val Phe Leu His 
            820                 825                 830         


Ile Ser Ser Ile Gly Lys Leu Ala Met Ile Phe Val Leu Gly Leu Ile 
        835                 840                 845             


Tyr Leu Val Leu Leu Leu Leu Gly Pro Pro Ala Thr Ile Phe Asp Asn 
    850                 855                 860                 


Tyr Asp Leu Leu Leu Gly Val His Gly Leu Ala Ser Ser Asn Glu Thr 
865                 870                 875                 880 


Phe Asp Gly Leu Asp Cys Pro Ala Ala Gly Arg Val Ala Leu Lys Tyr 
                885                 890                 895     


Met Thr Pro Val Ile Leu Leu Val Phe Ala Leu Ala Leu Tyr Leu His 
            900                 905                 910         


Ala Gln Gln Val Glu Ser Thr Ala Arg Leu Asp Phe Leu Trp Lys Leu 
        915                 920                 925             


Gln Ala Thr Gly Glu Lys Glu Glu Met Glu Glu Leu Gln Ala Tyr Asn 
    930                 935                 940                 


Arg Arg Leu Leu His Asn Ile Leu Pro Lys Asp Val Ala Ala His Phe 
945                 950                 955                 960 


Leu Ala Arg Glu Arg Arg Asn Asp Glu Leu Tyr Tyr Gln Ser Cys Glu 
                965                 970                 975     


Cys Val Ala Val Met Phe Ala Ser Ile Ala Asn Phe Ser Glu Phe Tyr 
            980                 985                 990         


Val Glu Leu Glu Ala Asn Asn Glu  Gly Val Glu Cys Leu  Arg Leu Leu 
        995                 1000                 1005             


Asn Glu  Ile Ile Ala Asp Phe  Asp Glu Ile Ile Ser  Glu Glu Arg 
    1010                 1015                 1020             


Phe Arg  Gln Leu Glu Lys Ile  Lys Thr Ile Gly Ser  Thr Tyr Met 
    1025                 1030                 1035             


Ala Ala  Ser Gly Leu Asn Ala  Ser Thr Tyr Asp Gln  Val Gly Arg 
    1040                 1045                 1050             


Ser His  Ile Thr Ala Leu Ala  Asp Tyr Ala Met Arg  Leu Met Glu 
    1055                 1060                 1065             


Gln Met  Lys His Ile Asn Glu  His Ser Phe Asn Asn  Phe Gln Met 
    1070                 1075                 1080             


Lys Ile  Gly Leu Asn Met Gly  Pro Val Val Ala Gly  Val Ile Gly 
    1085                 1090                 1095             


Ala Arg  Lys Pro Gln Tyr Asp  Ile Trp Gly Asn Thr  Val Asn Val 
    1100                 1105                 1110             


Ser Ser  Arg Met Asp Ser Thr  Gly Val Pro Asp Arg  Ile Gln Val 
    1115                 1120                 1125             


Thr Thr  Asp Leu Tyr Gln Val  Leu Ala Ala Lys Gly  Tyr Gln Leu 
    1130                 1135                 1140             


Glu Cys  Arg Gly Val Val Lys  Val Lys Gly Lys Gly  Glu Met Thr 
    1145                 1150                 1155             


Thr Tyr  Phe Leu Asn Gly Gly  Pro Ser Ser 
    1160                 1165             


<210>  246
<211>  1080
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY7__Homo_sapiens__NP_001105

<400>  246

Met Pro Ala Lys Gly Arg Tyr Phe Leu Asn Glu Gly Glu Glu Gly Pro 
1               5                   10                  15      


Asp Gln Asp Ala Leu Tyr Glu Lys Tyr Gln Leu Thr Ser Gln His Gly 
            20                  25                  30          


Pro Leu Leu Leu Thr Leu Leu Leu Val Ala Ala Thr Ala Cys Val Ala 
        35                  40                  45              


Leu Ile Ile Ile Ala Phe Ser Gln Gly Asp Pro Ser Arg His Gln Ala 
    50                  55                  60                  


Ile Leu Gly Met Ala Phe Leu Val Leu Ala Val Phe Ala Ala Leu Ser 
65                  70                  75                  80  


Val Leu Met Tyr Val Glu Cys Leu Leu Arg Arg Trp Leu Arg Ala Leu 
                85                  90                  95      


Ala Leu Leu Thr Trp Ala Cys Leu Val Ala Leu Gly Tyr Val Leu Val 
            100                 105                 110         


Phe Asp Ala Trp Thr Lys Ala Ala Cys Ala Trp Glu Gln Val Pro Phe 
        115                 120                 125             


Phe Leu Phe Ile Val Phe Val Val Tyr Thr Leu Leu Pro Phe Ser Met 
    130                 135                 140                 


Arg Gly Ala Val Ala Val Gly Ala Val Ser Thr Ala Ser His Leu Leu 
145                 150                 155                 160 


Val Leu Gly Ser Leu Met Gly Gly Phe Thr Thr Pro Ser Val Arg Val 
                165                 170                 175     


Gly Leu Gln Leu Leu Ala Asn Ala Val Ile Phe Leu Cys Gly Asn Leu 
            180                 185                 190         


Thr Gly Ala Phe His Lys His Gln Met Gln Asp Ala Ser Arg Asp Leu 
        195                 200                 205             


Phe Thr Tyr Thr Val Lys Cys Ile Gln Ile Arg Arg Lys Leu Arg Ile 
    210                 215                 220                 


Glu Lys Arg Gln Gln Glu Asn Leu Leu Leu Ser Val Leu Pro Ala His 
225                 230                 235                 240 


Ile Ser Met Gly Met Lys Leu Ala Ile Ile Glu Arg Leu Lys Glu His 
                245                 250                 255     


Gly Asp Arg Arg Cys Met Pro Asp Asn Asn Phe His Ser Leu Tyr Val 
            260                 265                 270         


Lys Arg His Gln Asn Val Ser Ile Leu Tyr Ala Asp Ile Val Gly Phe 
        275                 280                 285             


Thr Gln Leu Ala Ser Asp Cys Ser Pro Lys Glu Leu Val Val Val Leu 
    290                 295                 300                 


Asn Glu Leu Phe Gly Lys Phe Asp Gln Ile Ala Lys Ala Asn Glu Cys 
305                 310                 315                 320 


Met Arg Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu 
                325                 330                 335     


Pro Val Ser Leu Pro Thr His Ala Arg Asn Cys Val Lys Met Gly Leu 
            340                 345                 350         


Asp Met Cys Gln Ala Ile Lys Gln Val Arg Glu Ala Thr Gly Val Asp 
        355                 360                 365             


Ile Asn Met Arg Val Gly Ile His Ser Gly Asn Val Leu Cys Gly Val 
    370                 375                 380                 


Ile Gly Leu Arg Lys Trp Gln Tyr Asp Val Trp Ser His Asp Val Ser 
385                 390                 395                 400 


Leu Ala Asn Arg Met Glu Ala Ala Gly Val Pro Gly Arg Val His Ile 
                405                 410                 415     


Thr Glu Ala Thr Leu Lys His Leu Asp Lys Ala Tyr Glu Val Glu Asp 
            420                 425                 430         


Gly His Gly Gln Gln Arg Asp Pro Tyr Leu Lys Glu Met Asn Ile Arg 
        435                 440                 445             


Thr Tyr Leu Val Ile Asp Pro Arg Ser Gln Gln Pro Pro Pro Pro Ser 
    450                 455                 460                 


Gln His Leu Pro Arg Pro Lys Gly Asp Ala Ala Leu Lys Met Arg Ala 
465                 470                 475                 480 


Ser Val Arg Met Thr Arg Tyr Leu Glu Ser Trp Gly Ala Ala Arg Pro 
                485                 490                 495     


Phe Ala His Leu Asn His Arg Glu Ser Val Ser Ser Gly Glu Thr His 
            500                 505                 510         


Val Pro Asn Gly Arg Arg Pro Lys Ser Val Pro Gln Arg His Arg Arg 
        515                 520                 525             


Thr Pro Asp Arg Ser Met Ser Pro Lys Gly Arg Ser Glu Asp Asp Ser 
    530                 535                 540                 


Tyr Asp Asp Glu Met Leu Ser Ala Ile Glu Gly Leu Ser Ser Thr Arg 
545                 550                 555                 560 


Pro Cys Cys Ser Lys Ser Asp Asp Phe Tyr Thr Phe Gly Ser Ile Phe 
                565                 570                 575     


Leu Glu Lys Gly Phe Glu Arg Glu Tyr Arg Leu Ala Pro Ile Pro Arg 
            580                 585                 590         


Ala Arg His Asp Phe Ala Cys Ala Ser Leu Ile Phe Val Cys Ile Leu 
        595                 600                 605             


Leu Val His Val Leu Leu Met Pro Arg Thr Ala Ala Leu Gly Val Ser 
    610                 615                 620                 


Phe Gly Leu Val Ala Cys Val Leu Gly Leu Val Leu Gly Leu Cys Phe 
625                 630                 635                 640 


Ala Thr Lys Phe Ser Arg Cys Cys Pro Ala Arg Gly Thr Leu Cys Thr 
                645                 650                 655     


Ile Ser Glu Arg Val Glu Thr Gln Pro Leu Leu Arg Leu Thr Leu Ala 
            660                 665                 670         


Val Leu Thr Ile Gly Ser Leu Leu Thr Val Ala Ile Ile Asn Leu Pro 
        675                 680                 685             


Leu Met Pro Phe Gln Val Pro Glu Leu Pro Val Gly Asn Glu Thr Gly 
    690                 695                 700                 


Leu Leu Ala Ala Ser Ser Lys Thr Arg Ala Leu Cys Glu Pro Leu Pro 
705                 710                 715                 720 


Tyr Tyr Thr Cys Ser Cys Val Leu Gly Phe Ile Ala Cys Ser Val Phe 
                725                 730                 735     


Leu Arg Met Ser Leu Glu Pro Lys Val Val Leu Leu Thr Val Ala Leu 
            740                 745                 750         


Val Ala Tyr Leu Val Leu Phe Asn Leu Ser Pro Cys Trp Gln Trp Asp 
        755                 760                 765             


Cys Cys Gly Gln Gly Leu Gly Asn Leu Thr Lys Pro Asn Gly Thr Thr 
    770                 775                 780                 


Ser Gly Thr Pro Ser Cys Ser Trp Lys Asp Leu Lys Thr Met Thr Asn 
785                 790                 795                 800 


Phe Tyr Leu Val Leu Phe Tyr Ile Thr Leu Leu Thr Leu Ser Arg Gln 
                805                 810                 815     


Ile Asp Tyr Tyr Cys Arg Leu Asp Cys Leu Trp Lys Lys Lys Phe Lys 
            820                 825                 830         


Lys Glu His Glu Glu Phe Glu Thr Met Glu Asn Val Asn Arg Leu Leu 
        835                 840                 845             


Leu Glu Asn Val Leu Pro Ala His Val Ala Ala His Phe Ile Gly Asp 
    850                 855                 860                 


Lys Leu Asn Glu Asp Trp Tyr His Gln Ser Tyr Asp Cys Val Cys Val 
865                 870                 875                 880 


Met Phe Ala Ser Val Pro Asp Phe Lys Val Phe Tyr Thr Glu Cys Asp 
                885                 890                 895     


Val Asn Lys Glu Gly Leu Glu Cys Leu Arg Leu Leu Asn Glu Ile Ile 
            900                 905                 910         


Ala Asp Phe Asp Glu Leu Leu Leu Lys Pro Lys Phe Ser Gly Val Glu 
        915                 920                 925             


Lys Ile Lys Thr Ile Gly Ser Thr Tyr Met Ala Ala Ala Gly Leu Ser 
    930                 935                 940                 


Val Ala Ser Gly His Glu Asn Gln Glu Leu Glu Arg Gln His Ala His 
945                 950                 955                 960 


Ile Gly Val Met Val Glu Phe Ser Ile Ala Leu Met Ser Lys Leu Asp 
                965                 970                 975     


Gly Ile Asn Arg His Ser Phe Asn Ser Phe Arg Leu Arg Val Gly Ile 
            980                 985                 990         


Asn His Gly Pro Val Ile Ala Gly  Val Ile Gly Ala Arg  Lys Pro Gln 
        995                 1000                 1005             


Tyr Asp  Ile Trp Gly Asn Thr  Val Asn Val Ala Ser  Arg Met Glu 
    1010                 1015                 1020             


Ser Thr  Gly Glu Leu Gly Lys  Ile Gln Val Thr Glu  Glu Thr Cys 
    1025                 1030                 1035             


Thr Ile  Leu Gln Gly Leu Gly  Tyr Ser Cys Glu Cys  Arg Gly Leu 
    1040                 1045                 1050             


Ile Asn  Val Lys Gly Lys Gly  Glu Leu Arg Thr Tyr  Phe Val Cys 
    1055                 1060                 1065             


Thr Asp  Thr Ala Lys Phe Gln  Gly Leu Gly Leu Asn  
    1070                 1075                 1080 


<210>  247
<211>  1251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY8__Homo_sapiens__NP_001106

<400>  247

Met Glu Leu Ser Asp Val Arg Cys Leu Thr Gly Ser Glu Glu Leu Tyr 
1               5                   10                  15      


Thr Ile His Pro Thr Pro Pro Ala Gly Asp Gly Arg Ser Ala Ser Arg 
            20                  25                  30          


Pro Gln Arg Leu Leu Trp Gln Thr Ala Val Arg His Ile Thr Glu Gln 
        35                  40                  45              


Arg Phe Ile His Gly His Arg Gly Gly Ser Gly Ser Gly Ser Gly Gly 
    50                  55                  60                  


Ser Gly Lys Ala Ser Asp Pro Ala Gly Gly Gly Pro Asn His His Ala 
65                  70                  75                  80  


Pro Gln Leu Ser Gly Asp Ser Ala Leu Pro Leu Tyr Ser Leu Gly Pro 
                85                  90                  95      


Gly Glu Arg Ala His Ser Thr Cys Gly Thr Lys Val Phe Pro Glu Arg 
            100                 105                 110         


Ser Gly Ser Gly Ser Ala Ser Gly Ser Gly Gly Gly Gly Asp Leu Gly 
        115                 120                 125             


Phe Leu His Leu Asp Cys Ala Pro Ser Asn Ser Asp Phe Phe Leu Asn 
    130                 135                 140                 


Gly Gly Tyr Ser Tyr Arg Gly Val Ile Phe Pro Thr Leu Arg Asn Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Asp Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Leu Gly 
                165                 170                 175     


Gln Arg Arg Lys Ser Glu Val Val Met Asn Val Leu Asp Val Leu Thr 
            180                 185                 190         


Lys Leu Thr Leu Leu Val Leu His Leu Ser Leu Ala Ser Ala Pro Met 
        195                 200                 205             


Asp Pro Leu Lys Gly Ile Leu Leu Gly Phe Phe Thr Gly Ile Glu Val 
    210                 215                 220                 


Val Ile Cys Ala Leu Val Val Val Arg Lys Asp Thr Thr Ser His Thr 
225                 230                 235                 240 


Tyr Leu Gln Tyr Ser Gly Val Val Thr Trp Val Ala Met Thr Thr Gln 
                245                 250                 255     


Ile Leu Ala Ala Gly Leu Gly Tyr Gly Leu Leu Gly Asp Gly Ile Gly 
            260                 265                 270         


Tyr Val Leu Phe Thr Leu Phe Ala Thr Tyr Ser Met Leu Pro Leu Pro 
        275                 280                 285             


Leu Thr Trp Ala Ile Leu Ala Gly Leu Gly Thr Ser Leu Leu Gln Val 
    290                 295                 300                 


Ile Leu Gln Val Val Ile Pro Arg Leu Ala Val Ile Ser Ile Asn Gln 
305                 310                 315                 320 


Val Val Ala Gln Ala Val Leu Phe Met Cys Met Asn Thr Ala Gly Ile 
                325                 330                 335     


Phe Ile Ser Tyr Leu Ser Asp Arg Ala Gln Arg Gln Ala Phe Leu Glu 
            340                 345                 350         


Thr Arg Arg Cys Val Glu Ala Arg Leu Arg Leu Glu Thr Glu Asn Gln 
        355                 360                 365             


Arg Gln Glu Arg Leu Val Leu Ser Val Leu Pro Arg Phe Val Val Leu 
    370                 375                 380                 


Glu Met Ile Asn Asp Met Thr Asn Val Glu Asp Glu His Leu Gln His 
385                 390                 395                 400 


Gln Phe His Arg Ile Tyr Ile His Arg Tyr Glu Asn Val Ser Ile Leu 
                405                 410                 415     


Phe Ala Asp Val Lys Gly Phe Thr Asn Leu Ser Thr Thr Leu Ser Ala 
            420                 425                 430         


Gln Glu Leu Val Arg Met Leu Asn Glu Leu Phe Ala Arg Phe Asp Arg 
        435                 440                 445             


Leu Ala His Glu His His Cys Leu Arg Ile Lys Ile Leu Gly Asp Cys 
    450                 455                 460                 


Tyr Tyr Cys Val Ser Gly Leu Pro Glu Pro Arg Gln Asp His Ala His 
465                 470                 475                 480 


Cys Cys Val Glu Met Gly Leu Ser Met Ile Lys Thr Ile Arg Tyr Val 
                485                 490                 495     


Arg Ser Arg Thr Lys His Asp Val Asp Met Arg Ile Gly Ile His Ser 
            500                 505                 510         


Gly Ser Val Leu Cys Gly Val Leu Gly Leu Arg Lys Trp Gln Phe Asp 
        515                 520                 525             


Val Trp Ser Trp Asp Val Asp Ile Ala Asn Lys Leu Glu Ser Gly Gly 
    530                 535                 540                 


Ile Pro Gly Arg Ile His Ile Ser Lys Ala Thr Leu Asp Cys Leu Asn 
545                 550                 555                 560 


Gly Asp Tyr Asn Val Glu Glu Gly His Gly Lys Glu Arg Asn Glu Phe 
                565                 570                 575     


Leu Arg Lys His Asn Ile Glu Thr Tyr Leu Ile Lys Gln Pro Glu Asp 
            580                 585                 590         


Ser Leu Leu Ser Leu Pro Glu Asp Ile Val Lys Glu Ser Val Ser Ser 
        595                 600                 605             


Ser Asp Arg Arg Asn Ser Gly Ala Thr Phe Thr Glu Gly Ser Trp Ser 
    610                 615                 620                 


Pro Glu Leu Pro Phe Asp Asn Ile Val Gly Lys Gln Asn Thr Leu Ala 
625                 630                 635                 640 


Ala Leu Thr Arg Asn Ser Ile Asn Leu Leu Pro Asn His Leu Ala Gln 
                645                 650                 655     


Ala Leu His Val Gln Ser Gly Pro Glu Glu Ile Asn Lys Arg Ile Glu 
            660                 665                 670         


His Thr Ile Asp Leu Arg Ser Gly Asp Lys Leu Arg Arg Glu His Ile 
        675                 680                 685             


Lys Pro Phe Ser Leu Met Phe Lys Asp Ser Ser Leu Glu His Lys Tyr 
    690                 695                 700                 


Ser Gln Met Arg Asp Glu Val Phe Lys Ser Asn Leu Val Cys Ala Phe 
705                 710                 715                 720 


Ile Val Leu Leu Phe Ile Thr Ala Ile Gln Ser Leu Leu Pro Ser Ser 
                725                 730                 735     


Arg Val Met Pro Met Thr Ile Gln Phe Ser Ile Leu Ile Met Leu His 
            740                 745                 750         


Ser Ala Leu Val Leu Ile Thr Thr Ala Glu Asp Tyr Lys Cys Leu Pro 
        755                 760                 765             


Leu Ile Leu Arg Lys Thr Cys Cys Trp Ile Asn Glu Thr Tyr Leu Ala 
    770                 775                 780                 


Arg Asn Val Ile Ile Phe Ala Ser Ile Leu Ile Asn Phe Leu Gly Ala 
785                 790                 795                 800 


Ile Leu Asn Ile Leu Trp Cys Asp Phe Asp Lys Ser Ile Pro Leu Lys 
                805                 810                 815     


Asn Leu Thr Phe Asn Ser Ser Ala Val Phe Thr Asp Ile Cys Ser Tyr 
            820                 825                 830         


Pro Glu Tyr Phe Val Phe Thr Gly Val Leu Ala Met Val Thr Cys Ala 
        835                 840                 845             


Val Phe Leu Arg Leu Asn Ser Val Leu Lys Leu Ala Val Leu Leu Ile 
    850                 855                 860                 


Met Ile Ala Ile Tyr Ala Leu Leu Thr Glu Thr Val Tyr Ala Gly Leu 
865                 870                 875                 880 


Phe Leu Arg Tyr Asp Asn Leu Asn His Ser Gly Glu Asp Phe Leu Gly 
                885                 890                 895     


Thr Lys Glu Val Ser Leu Leu Leu Met Ala Met Phe Leu Leu Ala Val 
            900                 905                 910         


Phe Tyr His Gly Gln Gln Leu Glu Tyr Thr Ala Arg Leu Asp Phe Leu 
        915                 920                 925             


Trp Arg Val Gln Ala Lys Glu Glu Ile Asn Glu Met Lys Glu Leu Arg 
    930                 935                 940                 


Glu His Asn Glu Asn Met Leu Arg Asn Ile Leu Pro Ser His Val Ala 
945                 950                 955                 960 


Arg His Phe Leu Glu Lys Asp Arg Asp Asn Glu Glu Leu Tyr Ser Gln 
                965                 970                 975     


Ser Tyr Asp Ala Val Gly Val Met Phe Ala Ser Ile Pro Gly Phe Ala 
            980                 985                 990         


Asp Phe Tyr Ser Gln Thr Glu Met  Asn Asn Gln Gly Val  Glu Cys Leu 
        995                 1000                 1005             


Arg Leu  Leu Asn Glu Ile Ile  Ala Asp Phe Asp Glu  Leu Leu Gly 
    1010                 1015                 1020             


Glu Asp  Arg Phe Gln Asp Ile  Glu Lys Ile Lys Thr  Ile Gly Ser 
    1025                 1030                 1035             


Thr Tyr  Met Ala Val Ser Gly  Leu Ser Pro Glu Lys  Gln Gln Cys 
    1040                 1045                 1050             


Glu Asp  Lys Trp Gly His Leu  Cys Ala Leu Ala Asp  Phe Ser Leu 
    1055                 1060                 1065             


Ala Leu  Thr Glu Ser Ile Gln  Glu Ile Asn Lys His  Ser Phe Asn 
    1070                 1075                 1080             


Asn Phe  Glu Leu Arg Ile Gly  Ile Ser His Gly Ser  Val Val Ala 
    1085                 1090                 1095             


Gly Val  Ile Gly Ala Lys Lys  Pro Gln Tyr Asp Ile  Trp Gly Lys 
    1100                 1105                 1110             


Thr Val  Asn Leu Ala Ser Arg  Met Asp Ser Thr Gly  Val Ser Gly 
    1115                 1120                 1125             


Arg Ile  Gln Val Pro Glu Glu  Thr Tyr Leu Ile Leu  Lys Asp Gln 
    1130                 1135                 1140             


Gly Phe  Ala Phe Asp Tyr Arg  Gly Glu Ile Tyr Val  Lys Gly Ile 
    1145                 1150                 1155             


Ser Glu  Gln Glu Gly Lys Ile  Lys Thr Tyr Phe Leu  Leu Gly Arg 
    1160                 1165                 1170             


Val Gln  Pro Asn Pro Phe Ile  Leu Pro Pro Arg Arg  Leu Pro Gly 
    1175                 1180                 1185             


Gln Tyr  Ser Leu Ala Ala Val  Val Leu Gly Leu Val  Gln Ser Leu 
    1190                 1195                 1200             


Asn Arg  Gln Arg Gln Lys Gln  Leu Leu Asn Glu Asn  Asn Asn Thr 
    1205                 1210                 1215             


Gly Ile  Ile Lys Gly His Tyr  Asn Arg Arg Thr Leu  Leu Ser Pro 
    1220                 1225                 1230             


Ser Gly  Thr Glu Pro Gly Ala  Gln Ala Glu Gly Thr  Asp Lys Ser 
    1235                 1240                 1245             


Asp Leu  Pro 
    1250     


<210>  248
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCY9__Homo_sapiens__NP_001107

<400>  248

Met Ala Ser Pro Pro His Gln Gln Leu Leu His His His Ser Thr Glu 
1               5                   10                  15      


Val Ser Cys Asp Ser Ser Gly Asp Ser Asn Ser Val Arg Val Lys Ile 
            20                  25                  30          


Asn Pro Lys Gln Leu Ser Ser Asn Ser His Pro Lys His Cys Lys Tyr 
        35                  40                  45              


Ser Ile Ser Ser Ser Cys Ser Ser Ser Gly Asp Ser Gly Gly Val Pro 
    50                  55                  60                  


Arg Arg Val Gly Gly Gly Gly Arg Leu Arg Arg Gln Lys Lys Leu Pro 
65                  70                  75                  80  


Gln Leu Phe Glu Arg Ala Ser Ser Arg Trp Trp Asp Pro Lys Phe Asp 
                85                  90                  95      


Ser Val Asn Leu Glu Glu Ala Cys Leu Glu Arg Cys Phe Pro Gln Thr 
            100                 105                 110         


Gln Arg Arg Phe Arg Tyr Ala Leu Phe Tyr Ile Gly Phe Ala Cys Leu 
        115                 120                 125             


Leu Trp Ser Ile Tyr Phe Ala Val His Met Arg Ser Arg Leu Ile Val 
    130                 135                 140                 


Met Val Ala Pro Ala Leu Cys Phe Leu Leu Val Cys Val Gly Phe Phe 
145                 150                 155                 160 


Leu Phe Thr Phe Thr Lys Leu Tyr Ala Arg His Tyr Ala Trp Thr Ser 
                165                 170                 175     


Leu Ala Leu Thr Leu Leu Val Phe Ala Leu Thr Leu Ala Ala Gln Phe 
            180                 185                 190         


Gln Val Leu Thr Pro Val Ser Gly Arg Gly Asp Ser Ser Asn Leu Thr 
        195                 200                 205             


Ala Thr Ala Arg Pro Thr Asp Thr Cys Leu Ser Gln Val Gly Ser Phe 
    210                 215                 220                 


Ser Met Cys Ile Glu Val Leu Phe Leu Leu Tyr Thr Val Met His Leu 
225                 230                 235                 240 


Pro Leu Tyr Leu Ser Leu Cys Leu Gly Val Ala Tyr Ser Val Leu Phe 
                245                 250                 255     


Glu Thr Phe Gly Tyr His Phe Arg Asp Glu Ala Cys Phe Pro Ser Pro 
            260                 265                 270         


Gly Ala Gly Ala Leu His Trp Glu Leu Leu Ser Arg Gly Leu Leu His 
        275                 280                 285             


Gly Cys Ile His Ala Ile Gly Val His Leu Phe Val Met Ser Gln Val 
    290                 295                 300                 


Arg Ser Arg Ser Thr Phe Leu Lys Val Gly Gln Ser Ile Met His Gly 
305                 310                 315                 320 


Lys Asp Leu Glu Val Glu Lys Ala Leu Lys Glu Arg Met Ile His Ser 
                325                 330                 335     


Val Met Pro Arg Ile Ile Ala Asp Asp Leu Met Lys Gln Gly Asp Glu 
            340                 345                 350         


Glu Ser Glu Asn Ser Val Lys Arg His Ala Thr Ser Ser Pro Lys Asn 
        355                 360                 365             


Arg Lys Lys Lys Ser Ser Ile Gln Lys Ala Pro Ile Ala Phe Arg Pro 
    370                 375                 380                 


Phe Lys Met Gln Gln Ile Glu Glu Val Ser Ile Leu Phe Ala Asp Ile 
385                 390                 395                 400 


Val Gly Phe Thr Lys Met Ser Ala Asn Lys Ser Ala His Ala Leu Val 
                405                 410                 415     


Gly Leu Leu Asn Asp Leu Phe Gly Arg Phe Asp Arg Leu Cys Glu Glu 
            420                 425                 430         


Thr Lys Cys Glu Lys Ile Ser Thr Leu Gly Asp Cys Tyr Tyr Cys Val 
        435                 440                 445             


Ala Gly Cys Pro Glu Pro Arg Ala Asp His Ala Tyr Cys Cys Ile Glu 
    450                 455                 460                 


Met Gly Leu Gly Met Ile Lys Ala Ile Glu Gln Phe Cys Gln Glu Lys 
465                 470                 475                 480 


Lys Glu Met Val Asn Met Arg Val Gly Val His Thr Gly Thr Val Leu 
                485                 490                 495     


Cys Gly Ile Leu Gly Met Arg Arg Phe Lys Phe Asp Val Trp Ser Asn 
            500                 505                 510         


Asp Val Asn Leu Ala Asn Leu Met Glu Gln Leu Gly Val Ala Gly Lys 
        515                 520                 525             


Val His Ile Ser Glu Ala Thr Ala Lys Tyr Leu Asp Asp Arg Tyr Glu 
    530                 535                 540                 


Met Glu Asp Gly Lys Val Ile Glu Arg Leu Gly Gln Ser Val Val Ala 
545                 550                 555                 560 


Asp Gln Leu Lys Gly Leu Lys Thr Tyr Leu Ile Ser Gly Gln Arg Ala 
                565                 570                 575     


Lys Glu Ser Arg Cys Ser Cys Ala Glu Ala Leu Leu Ser Gly Phe Glu 
            580                 585                 590         


Val Ile Asp Gly Ser Gln Val Ser Ser Gly Pro Arg Gly Gln Gly Thr 
        595                 600                 605             


Ala Ser Ser Gly Asn Val Ser Asp Leu Ala Gln Thr Val Lys Thr Phe 
    610                 615                 620                 


Asp Asn Leu Lys Thr Cys Pro Ser Cys Gly Ile Thr Phe Ala Pro Lys 
625                 630                 635                 640 


Ser Glu Ala Gly Ala Glu Gly Gly Ala Pro Gln Asn Gly Cys Gln Asp 
                645                 650                 655     


Glu His Lys Asn Ser Thr Lys Ala Ser Gly Gly Pro Asn Pro Lys Thr 
            660                 665                 670         


Gln Asn Gly Leu Leu Ser Pro Pro Gln Glu Glu Lys Leu Thr Asn Ser 
        675                 680                 685             


Gln Thr Ser Leu Cys Glu Ile Leu Gln Glu Lys Gly Arg Trp Ala Gly 
    690                 695                 700                 


Val Ser Leu Asp Gln Ser Ala Leu Leu Pro Leu Arg Phe Lys Asn Ile 
705                 710                 715                 720 


Arg Glu Lys Thr Asp Ala His Phe Val Asp Val Ile Lys Glu Asp Ser 
                725                 730                 735     


Leu Met Lys Asp Tyr Phe Phe Lys Pro Pro Ile Asn Gln Phe Ser Leu 
            740                 745                 750         


Asn Phe Leu Asp Gln Glu Leu Glu Arg Ser Tyr Arg Thr Ser Tyr Gln 
        755                 760                 765             


Glu Glu Val Ile Lys Asn Ser Pro Val Lys Thr Phe Ala Ser Pro Thr 
    770                 775                 780                 


Phe Ser Ser Leu Leu Asp Val Phe Leu Ser Thr Thr Val Phe Leu Thr 
785                 790                 795                 800 


Leu Ser Thr Thr Cys Phe Leu Lys Tyr Glu Ala Ala Thr Val Pro Pro 
                805                 810                 815     


Pro Pro Ala Ala Leu Ala Val Phe Ser Ala Ala Leu Leu Leu Glu Val 
            820                 825                 830         


Leu Ser Leu Ala Val Ser Ile Arg Met Val Phe Phe Leu Glu Asp Val 
        835                 840                 845             


Met Ala Cys Thr Lys Arg Leu Leu Glu Trp Ile Ala Gly Trp Leu Pro 
    850                 855                 860                 


Arg His Cys Ile Gly Ala Ile Leu Val Ser Leu Pro Ala Leu Ala Val 
865                 870                 875                 880 


Tyr Ser His Val Thr Ser Glu Tyr Glu Thr Asn Ile His Phe Pro Val 
                885                 890                 895     


Phe Thr Gly Ser Ala Ala Leu Ile Ala Val Val His Tyr Cys Asn Phe 
            900                 905                 910         


Cys Gln Leu Ser Ser Trp Met Arg Ser Ser Leu Ala Thr Val Val Gly 
        915                 920                 925             


Ala Gly Pro Leu Leu Leu Leu Tyr Val Ser Leu Cys Pro Asp Ser Ser 
    930                 935                 940                 


Val Leu Thr Ser Pro Leu Asp Ala Val Gln Asn Phe Ser Ser Glu Arg 
945                 950                 955                 960 


Asn Pro Cys Asn Ser Ser Val Pro Arg Asp Leu Arg Arg Pro Ala Ser 
                965                 970                 975     


Leu Ile Gly Gln Glu Val Val Leu Val Phe Phe Leu Leu Leu Leu Leu 
            980                 985                 990         


Val Trp Phe Leu Asn Arg Glu Phe  Glu Val Ser Tyr Arg  Leu His Tyr 
        995                 1000                 1005             


His Gly  Asp Val Glu Ala Asp  Leu His Arg Thr Lys  Ile Gln Ser 
    1010                 1015                 1020             


Met Arg  Asp Gln Ala Asp Trp  Leu Leu Arg Asn Ile  Ile Pro Tyr 
    1025                 1030                 1035             


His Val  Ala Glu Gln Leu Lys  Val Ser Gln Thr Tyr  Ser Lys Asn 
    1040                 1045                 1050             


His Asp  Ser Gly Gly Val Ile  Phe Ala Ser Ile Val  Asn Phe Ser 
    1055                 1060                 1065             


Glu Phe  Tyr Glu Glu Asn Tyr  Glu Gly Gly Lys Glu  Cys Tyr Arg 
    1070                 1075                 1080             


Val Leu  Asn Glu Leu Ile Gly  Asp Phe Asp Glu Leu  Leu Ser Lys 
    1085                 1090                 1095             


Pro Asp  Tyr Ser Ser Ile Glu  Lys Ile Lys Thr Ile  Gly Ala Thr 
    1100                 1105                 1110             


Tyr Met  Ala Ala Ser Gly Leu  Asn Thr Ala Gln Ala  Gln Asp Gly 
    1115                 1120                 1125             


Ser His  Pro Gln Glu His Leu  Gln Ile Leu Phe Glu  Phe Ala Lys 
    1130                 1135                 1140             


Glu Met  Met Arg Val Val Asp  Asp Phe Asn Asn Asn  Met Leu Trp 
    1145                 1150                 1155             


Phe Asn  Phe Lys Leu Arg Val  Gly Phe Asn His Gly  Pro Leu Thr 
    1160                 1165                 1170             


Ala Gly  Val Ile Gly Thr Thr  Lys Leu Leu Tyr Asp  Ile Trp Gly 
    1175                 1180                 1185             


Asp Thr  Val Asn Ile Ala Ser  Arg Met Asp Thr Thr  Gly Val Glu 
    1190                 1195                 1200             


Cys Arg  Ile Gln Val Ser Glu  Glu Ser Tyr Arg Val  Leu Ser Lys 
    1205                 1210                 1215             


Met Gly  Tyr Asp Phe Asp Tyr  Arg Gly Thr Val Asn  Val Lys Gly 
    1220                 1225                 1230             


Lys Gly  Gln Met Lys Thr Tyr  Leu Tyr Pro Lys Cys  Thr Asp His 
    1235                 1240                 1245             


Arg Val  Ile Pro Gln His Gln  Leu Ser Ile Ser Pro  Asp Ile Arg 
    1250                 1255                 1260             


Val Gln  Val Asp Gly Ser Ile  Gly Arg Ser Pro Thr  Asp Glu Ile 
    1265                 1270                 1275             


Ala Asn  Leu Val Pro Ser Val  Gln Tyr Val Asp Lys  Thr Ser Leu 
    1280                 1285                 1290             


Gly Ser  Asp Ser Ser Thr Gln  Ala Lys Asp Ala His  Leu Ser Pro 
    1295                 1300                 1305             


Lys Arg  Pro Trp Lys Glu Pro  Val Lys Ala Glu Glu  Arg Gly Arg 
    1310                 1315                 1320             


Phe Gly  Lys Ala Ile Glu Lys  Asp Asp Cys Asp Glu  Thr Gly Ile 
    1325                 1330                 1335             


Glu Glu  Ala Asn Glu Leu Thr  Lys Leu Asn Val Ser  Lys Ser Val 
    1340                 1345                 1350             


<210>  249
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCYAP1__Homo_sapiens__NP_001093203

<400>  249

Met Thr Met Cys Ser Gly Ala Arg Leu Ala Leu Leu Val Tyr Gly Ile 
1               5                   10                  15      


Ile Met His Ser Ser Val Tyr Ser Ser Pro Ala Ala Ala Gly Leu Arg 
            20                  25                  30          


Phe Pro Gly Ile Arg Pro Glu Glu Glu Ala Tyr Gly Glu Asp Gly Asn 
        35                  40                  45              


Pro Leu Pro Asp Phe Asp Gly Ser Glu Pro Pro Gly Ala Gly Ser Pro 
    50                  55                  60                  


Ala Ser Ala Pro Arg Ala Ala Ala Ala Trp Tyr Arg Pro Ala Gly Arg 
65                  70                  75                  80  


Arg Asp Val Ala His Gly Ile Leu Asn Glu Ala Tyr Arg Lys Val Leu 
                85                  90                  95      


Asp Gln Leu Ser Ala Gly Lys His Leu Gln Ser Leu Val Ala Arg Gly 
            100                 105                 110         


Val Gly Gly Ser Leu Gly Gly Gly Ala Gly Asp Asp Ala Glu Pro Leu 
        115                 120                 125             


Ser Lys Arg His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr 
    130                 135                 140                 


Arg Lys Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys 
145                 150                 155                 160 


Arg Tyr Lys Gln Arg Val Lys Asn Lys Gly Arg Arg Ile Ala Tyr Leu 
                165                 170                 175     


<210>  250
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADCYAP1R1__Homo_sapiens__NP_001109

<400>  250

Met Ala Gly Val Val His Val Ser Leu Ala Ala Leu Leu Leu Leu Pro 
1               5                   10                  15      


Met Ala Pro Ala Met His Ser Asp Cys Ile Phe Lys Lys Glu Gln Ala 
            20                  25                  30          


Met Cys Leu Glu Lys Ile Gln Arg Ala Asn Glu Leu Met Gly Phe Asn 
        35                  40                  45              


Asp Ser Ser Pro Gly Cys Pro Gly Met Trp Asp Asn Ile Thr Cys Trp 
    50                  55                  60                  


Lys Pro Ala His Val Gly Glu Met Val Leu Val Ser Cys Pro Glu Leu 
65                  70                  75                  80  


Phe Arg Ile Phe Asn Pro Asp Gln Val Trp Glu Thr Glu Thr Ile Gly 
                85                  90                  95      


Glu Ser Asp Phe Gly Asp Ser Asn Ser Leu Asp Leu Ser Asp Met Gly 
            100                 105                 110         


Val Val Ser Arg Asn Cys Thr Glu Asp Gly Trp Ser Glu Pro Phe Pro 
        115                 120                 125             


His Tyr Phe Asp Ala Cys Gly Phe Asp Glu Tyr Glu Ser Glu Thr Gly 
    130                 135                 140                 


Asp Gln Asp Tyr Tyr Tyr Leu Ser Val Lys Ala Leu Tyr Thr Val Gly 
145                 150                 155                 160 


Tyr Ser Thr Ser Leu Val Thr Leu Thr Thr Ala Met Val Ile Leu Cys 
                165                 170                 175     


Arg Phe Arg Lys Leu His Cys Thr Arg Asn Phe Ile His Met Asn Leu 
            180                 185                 190         


Phe Val Ser Phe Met Leu Arg Ala Ile Ser Val Phe Ile Lys Asp Trp 
        195                 200                 205             


Ile Leu Tyr Ala Glu Gln Asp Ser Asn His Cys Phe Ile Ser Thr Val 
    210                 215                 220                 


Glu Cys Lys Ala Val Met Val Phe Phe His Tyr Cys Val Val Ser Asn 
225                 230                 235                 240 


Tyr Phe Trp Leu Phe Ile Glu Gly Leu Tyr Leu Phe Thr Leu Leu Val 
                245                 250                 255     


Glu Thr Phe Phe Pro Glu Arg Arg Tyr Phe Tyr Trp Tyr Thr Ile Ile 
            260                 265                 270         


Gly Trp Gly Thr Pro Thr Val Cys Val Thr Val Trp Ala Thr Leu Arg 
        275                 280                 285             


Leu Tyr Phe Asp Asp Thr Gly Cys Trp Asp Met Asn Asp Ser Thr Ala 
    290                 295                 300                 


Leu Trp Trp Val Ile Lys Gly Pro Val Val Gly Ser Ile Met Val Asn 
305                 310                 315                 320 


Phe Val Leu Phe Ile Gly Ile Ile Val Ile Leu Val Gln Lys Leu Gln 
                325                 330                 335     


Ser Pro Asp Met Gly Gly Asn Glu Ser Ser Ile Tyr Leu Arg Leu Ala 
            340                 345                 350         


Arg Ser Thr Leu Leu Leu Ile Pro Leu Phe Gly Ile His Tyr Thr Val 
        355                 360                 365             


Phe Ala Phe Ser Pro Glu Asn Val Ser Lys Arg Glu Arg Leu Val Phe 
    370                 375                 380                 


Glu Leu Gly Leu Gly Ser Phe Gln Gly Phe Val Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Gly Glu Val Gln Ala Glu Ile Lys Arg Lys Trp Arg 
                405                 410                 415     


Ser Trp Lys Val Asn Arg Tyr Phe Ala Val Asp Phe Lys His Arg His 
            420                 425                 430         


Pro Ser Leu Ala Ser Ser Gly Val Asn Gly Gly Thr Gln Leu Ser Ile 
        435                 440                 445             


Leu Ser Lys Ser Ser Ser Gln Ile Arg Met Ser Gly Leu Pro Ala Asp 
    450                 455                 460                 


Asn Leu Ala Thr 
465             


<210>  251
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADD1__Homo_sapiens__NP_001110

<400>  251

Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr 
1               5                   10                  15      


Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn 
            20                  25                  30          


Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp 
        35                  40                  45              


Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser 
    50                  55                  60                  


Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys 
65                  70                  75                  80  


Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                85                  90                  95      


Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly 
            100                 105                 110         


Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn 
        115                 120                 125             


Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu 
    130                 135                 140                 


Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly 
145                 150                 155                 160 


Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu 
                165                 170                 175     


Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val 
            180                 185                 190         


Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp 
        195                 200                 205             


Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His 
    210                 215                 220                 


Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile 
225                 230                 235                 240 


His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu 
                245                 250                 255     


Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp 
            260                 265                 270         


Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys 
        275                 280                 285             


Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu 
    290                 295                 300                 


Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn 
305                 310                 315                 320 


Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly 
                325                 330                 335     


Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys 
            340                 345                 350         


Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro 
        355                 360                 365             


Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu 
    370                 375                 380                 


Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu 
385                 390                 395                 400 


Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val 
                405                 410                 415     


Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro 
            420                 425                 430         


Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu 
        435                 440                 445             


Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Gly Gln Asn Gly Ser 
    450                 455                 460                 


Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr 
465                 470                 475                 480 


Ser Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro 
                485                 490                 495     


Lys Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln 
            500                 505                 510         


Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val 
        515                 520                 525             


Met Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala 
    530                 535                 540                 


Ile Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly 
545                 550                 555                 560 


Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg 
                565                 570                 575     


Arg Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu 
            580                 585                 590         


Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro 
        595                 600                 605             


His Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro 
    610                 615                 620                 


Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr 
625                 630                 635                 640 


Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro 
                645                 650                 655     


Met Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu 
            660                 665                 670         


Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val 
        675                 680                 685             


Ala Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp 
    690                 695                 700                 


Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys 
705                 710                 715                 720 


Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp 
                725                 730                 735     


Ser 
    


<210>  252
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADD2__Homo_sapiens__NP_001171984

<400>  252

Met Pro Arg Arg Arg Val Pro Gly Ala Asn Cys Lys Pro Thr Gly Lys 
1               5                   10                  15      


Met Ser Glu Glu Thr Val Pro Glu Ala Ala Ser Pro Pro Pro Pro Gln 
            20                  25                  30          


Gly Gln Pro Tyr Phe Asp Arg Phe Ser Glu Asp Asp Pro Glu Tyr Met 
        35                  40                  45              


Arg Leu Arg Asn Arg Ala Ala Asp Leu Arg Gln Asp Phe Asn Leu Met 
    50                  55                  60                  


Glu Gln Lys Lys Arg Val Thr Met Ile Leu Gln Ser Pro Ser Phe Arg 
65                  70                  75                  80  


Glu Glu Leu Glu Gly Leu Ile Gln Glu Gln Met Lys Lys Gly Asn Asn 
                85                  90                  95      


Ser Ser Asn Ile Trp Ala Leu Arg Gln Ile Ala Asp Phe Met Ala Ser 
            100                 105                 110         


Thr Ser His Ala Val Phe Pro Thr Ser Ser Met Asn Val Ser Met Met 
        115                 120                 125             


Thr Pro Ile Asn Asp Leu His Thr Ala Asp Ser Leu Asn Leu Ala Lys 
    130                 135                 140                 


Gly Glu Arg Leu Met Arg Cys Lys Ile Ser Ser Val Tyr Arg Leu Leu 
145                 150                 155                 160 


Asp Leu Tyr Gly Trp Ala Gln Leu Ser Asp Thr Tyr Val Thr Leu Arg 
                165                 170                 175     


Val Ser Lys Glu Gln Asp His Phe Leu Ile Ser Pro Lys Gly Val Ser 
            180                 185                 190         


Cys Ser Glu Val Thr Ala Ser Ser Leu Ile Lys Val Asn Ile Leu Gly 
        195                 200                 205             


Glu Val Val Glu Lys Gly Ser Ser Cys Phe Pro Val Asp Thr Thr Gly 
    210                 215                 220                 


Phe Cys Leu His Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Arg Cys 
225                 230                 235                 240 


Ile Ile His Leu His Thr Pro Ala Thr Ala Ala Val Ser Ala Met Lys 
                245                 250                 255     


Trp Gly Leu Leu Pro Val Ser His Asn Ala Leu Leu Val Gly Asp Met 
            260                 265                 270         


Ala Tyr Tyr Asp Phe Asn Gly Glu Met Glu Gln Glu Ala Asp Arg Ile 
        275                 280                 285             


Asn Leu Gln Lys Cys Leu Gly Pro Thr Cys Lys Ile Leu Val Leu Arg 
    290                 295                 300                 


Asn His Gly Val Val Ala Leu Gly Asp Thr Val Glu Glu Ala Phe Tyr 
305                 310                 315                 320 


Lys Ile Phe His Leu Gln Ala Ala Cys Glu Ile Gln Val Ser Ala Leu 
                325                 330                 335     


Ser Ser Ala Gly Gly Val Glu Asn Leu Ile Leu Leu Glu Gln Glu Lys 
            340                 345                 350         


His Arg Pro His Glu Val Gly Ser Val Gln Trp Ala Gly Ser Thr Phe 
        355                 360                 365             


Gly Pro Met Gln Lys Ser Arg Leu Gly Glu His Glu Phe Glu Ala Leu 
    370                 375                 380                 


Met Arg Met Leu Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Thr Tyr Arg 
385                 390                 395                 400 


His Pro Phe Val Gln Glu Lys Thr Lys His Lys Ser Glu Val Glu Ile 
                405                 410                 415     


Pro Ala Thr Val Thr Ala Phe Val Phe Glu Glu Asp Gly Ala Pro Val 
            420                 425                 430         


Pro Ala Leu Arg Gln His Ala Gln Lys Gln Gln Lys Glu Lys Thr Arg 
        435                 440                 445             


Trp Leu Asn Thr Pro Asn Thr Tyr Leu Arg Val Asn Val Ala Asp Glu 
    450                 455                 460                 


Val Gln Arg Ser Met Gly Ser Pro Arg Pro Lys Thr Thr Trp Met Lys 
465                 470                 475                 480 


Ala Asp Glu Val Glu Lys Ser Ser Ser Gly Met Pro Ile Arg Ile Glu 
                485                 490                 495     


Asn Pro Asn Gln Phe Val Pro Leu Tyr Thr Asp Pro Gln Glu Val Leu 
            500                 505                 510         


Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Arg Gln Asp Val Lys Ser 
        515                 520                 525             


Ala Gly Pro Gln Ser Gln Leu Leu Ala Ser Val Ile Ala Glu Lys Ser 
    530                 535                 540                 


Arg Ser Pro Val Glu Gln Arg Leu Pro Leu Thr Gly Gly Glu Thr Cys 
545                 550                 555                 560 


Leu Pro Ser Gly Ser Ser Val Pro Gly Ala Gly Leu Gln Asp Pro 
                565                 570                 575 


<210>  253
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADD3__Homo_sapiens__NP_058432

<400>  253

Met Ser Ser Asp Ala Ser Gln Gly Val Ile Thr Thr Pro Pro Pro Pro 
1               5                   10                  15      


Ser Met Pro His Lys Glu Arg Tyr Phe Asp Arg Ile Asn Glu Asn Asp 
            20                  25                  30          


Pro Glu Tyr Ile Arg Glu Arg Asn Met Ser Pro Asp Leu Arg Gln Asp 
        35                  40                  45              


Phe Asn Met Met Glu Gln Arg Lys Arg Val Thr Gln Ile Leu Gln Ser 
    50                  55                  60                  


Pro Ala Phe Arg Glu Asp Leu Glu Cys Leu Ile Gln Glu Gln Met Lys 
65                  70                  75                  80  


Lys Gly His Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                85                  90                  95      


Tyr Ile Met Ala Asn Ser Phe Ser Gly Phe Ser Ser Pro Pro Leu Ser 
            100                 105                 110         


Leu Gly Met Val Thr Pro Ile Asn Asp Leu Pro Gly Ala Asp Thr Ser 
        115                 120                 125             


Ser Tyr Val Lys Gly Glu Lys Leu Thr Arg Cys Lys Leu Ala Ser Leu 
    130                 135                 140                 


Tyr Arg Leu Val Asp Leu Phe Gly Trp Ala His Leu Ala Asn Thr Tyr 
145                 150                 155                 160 


Ile Ser Val Arg Ile Ser Lys Glu Gln Asp His Ile Ile Ile Ile Pro 
                165                 170                 175     


Arg Gly Leu Ser Phe Ser Glu Ala Thr Ala Ser Asn Leu Val Lys Val 
            180                 185                 190         


Asn Ile Ile Gly Glu Val Val Asp Gln Gly Ser Thr Asn Leu Lys Ile 
        195                 200                 205             


Asp His Thr Gly Phe Ser Pro His Ala Ala Ile Tyr Ser Thr Arg Pro 
    210                 215                 220                 


Asp Val Lys Cys Val Ile His Ile His Thr Leu Ala Thr Ala Ala Val 
225                 230                 235                 240 


Ser Ser Met Lys Cys Gly Ile Leu Pro Ile Ser Gln Glu Ser Leu Leu 
                245                 250                 255     


Leu Gly Asp Val Ala Tyr Tyr Asp Tyr Gln Gly Ser Leu Glu Glu Gln 
            260                 265                 270         


Glu Glu Arg Ile Gln Leu Gln Lys Val Leu Gly Pro Ser Cys Lys Val 
        275                 280                 285             


Leu Val Leu Arg Asn His Gly Val Val Ala Leu Gly Glu Thr Leu Glu 
    290                 295                 300                 


Glu Ala Phe His Tyr Ile Phe Asn Val Gln Leu Ala Cys Glu Ile Gln 
305                 310                 315                 320 


Val Gln Ala Leu Ala Gly Ala Gly Gly Val Asp Asn Leu His Val Leu 
                325                 330                 335     


Asp Phe Gln Lys Tyr Lys Ala Phe Thr Tyr Thr Val Ala Ala Ser Gly 
            340                 345                 350         


Gly Gly Gly Val Asn Met Gly Ser His Gln Lys Trp Lys Val Gly Glu 
        355                 360                 365             


Ile Glu Phe Glu Gly Leu Met Arg Thr Leu Asp Asn Leu Gly Tyr Arg 
    370                 375                 380                 


Thr Gly Tyr Ala Tyr Arg His Pro Leu Ile Arg Glu Lys Pro Arg His 
385                 390                 395                 400 


Lys Ser Asp Val Glu Ile Pro Ala Thr Val Thr Ala Phe Ser Phe Glu 
                405                 410                 415     


Asp Asp Thr Val Pro Leu Ser Pro Leu Lys Tyr Met Ala Gln Arg Gln 
            420                 425                 430         


Gln Arg Glu Lys Thr Arg Trp Leu Asn Ser Pro Asn Thr Tyr Met Lys 
        435                 440                 445             


Val Asn Val Pro Glu Glu Ser Arg Asn Gly Glu Thr Ser Pro Arg Thr 
    450                 455                 460                 


Lys Ile Thr Trp Met Lys Ala Glu Asp Ser Ser Lys Val Ser Gly Gly 
465                 470                 475                 480 


Thr Pro Ile Lys Ile Glu Asp Pro Asn Gln Phe Val Pro Leu Asn Thr 
                485                 490                 495     


Asn Pro Asn Glu Val Leu Glu Lys Arg Asn Lys Ile Arg Glu Gln Asn 
            500                 505                 510         


Arg Tyr Asp Leu Lys Thr Ala Gly Pro Gln Ser Gln Leu Leu Ala Gly 
        515                 520                 525             


Ile Val Val Asp Lys Pro Pro Ser Thr Met Gln Phe Glu Asp Asp Asp 
    530                 535                 540                 


His Gly Pro Pro Ala Pro Pro Asn Pro Phe Ser His Leu Thr Glu Gly 
545                 550                 555                 560 


Glu Leu Glu Glu Tyr Lys Arg Thr Ile Glu Arg Lys Gln Gln Gly Leu 
                565                 570                 575     


Glu Asp Ala Glu Gln Glu Leu Leu Ser Asp Asp Ala Ser Ser Val Ser 
            580                 585                 590         


Gln Ile Gln Ser Gln Thr Gln Ser Pro Gln Asn Val Pro Glu Lys Leu 
        595                 600                 605             


Glu Glu Asn His Glu Leu Phe Ser Lys Ser Phe Ile Ser Met Glu Val 
    610                 615                 620                 


Pro Val Met Val Val Asn Gly Lys Asp Asp Met His Asp Val Glu Asp 
625                 630                 635                 640 


Glu Leu Ala Lys Arg Val Ser Arg Leu Ser Thr Ser Thr Thr Ile Glu 
                645                 650                 655     


Asn Ile Glu Ile Thr Ile Lys Ser Pro Glu Lys Ile Glu Glu Val Leu 
            660                 665                 670         


Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys Lys Lys Lys Lys 
        675                 680                 685             


Phe Arg Thr Pro Ser Phe Leu Lys Lys Asn Lys Lys Lys Glu Lys Val 
    690                 695                 700                 


Glu Ala 
705     


<210>  254
<211>  1667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGB__Homo_sapiens__NP_078970

<400>  254

Met Ala Ser Lys Gln Thr Lys Lys Lys Glu Val His Arg Ile Asn Ser 
1               5                   10                  15      


Ala His Gly Ser Asp Lys Ser Lys Asp Phe Tyr Pro Phe Gly Ser Asn 
            20                  25                  30          


Val Gln Ser Gly Ser Thr Glu Gln Lys Lys Gly Lys Phe Pro Leu Trp 
        35                  40                  45              


Pro Glu Trp Ser Glu Ala Asp Ile Asn Ser Glu Lys Trp Asp Ala Gly 
    50                  55                  60                  


Lys Gly Ala Lys Glu Lys Asp Lys Thr Gly Lys Ser Pro Val Phe His 
65                  70                  75                  80  


Phe Phe Glu Asp Pro Glu Gly Lys Ile Glu Leu Pro Pro Ser Leu Lys 
                85                  90                  95      


Ile Tyr Ser Trp Lys Arg Pro Gln Asp Ile Leu Phe Ser Gln Thr Pro 
            100                 105                 110         


Val Val Val Lys Asn Glu Ile Thr Phe Asp Leu Phe Ser Ala Asn Glu 
        115                 120                 125             


His Leu Leu Cys Ser Glu Leu Met Arg Trp Ile Ile Ser Glu Ile Tyr 
    130                 135                 140                 


Ala Val Trp Lys Ile Phe Asn Gly Gly Ile Leu Ser Asn Tyr Phe Lys 
145                 150                 155                 160 


Gly Thr Ser Gly Glu Pro Pro Leu Leu Pro Trp Lys Pro Trp Glu His 
                165                 170                 175     


Ile Tyr Ser Leu Cys Lys Ala Val Lys Gly His Met Pro Leu Phe Asn 
            180                 185                 190         


Ser Tyr Gly Lys Tyr Val Val Lys Leu Tyr Trp Met Gly Cys Trp Arg 
        195                 200                 205             


Lys Ile Thr Ile Asp Asp Phe Leu Pro Phe Asp Glu Asp Asn Asn Leu 
    210                 215                 220                 


Leu Leu Pro Ala Thr Thr Tyr Glu Phe Glu Leu Trp Pro Met Leu Leu 
225                 230                 235                 240 


Ser Lys Ala Ile Ile Lys Leu Ala Asn Ile Asp Ile His Val Ala Asp 
                245                 250                 255     


Arg Arg Glu Leu Gly Glu Phe Thr Val Ile His Ala Leu Thr Gly Trp 
            260                 265                 270         


Leu Pro Glu Val Ile Ser Leu His Pro Gly Tyr Met Asp Lys Val Trp 
        275                 280                 285             


Glu Leu Leu Lys Glu Ile Leu Pro Glu Phe Lys Leu Ser Asp Glu Ala 
    290                 295                 300                 


Ser Ser Glu Ser Lys Ile Ala Val Leu Asp Ser Lys Leu Lys Glu Pro 
305                 310                 315                 320 


Gly Lys Glu Gly Lys Glu Gly Lys Glu Ile Lys Asp Gly Lys Glu Val 
                325                 330                 335     


Lys Asp Val Lys Glu Phe Lys Pro Glu Ser Ser Leu Thr Thr Leu Lys 
            340                 345                 350         


Ala Pro Glu Lys Ser Asp Lys Val Pro Lys Glu Lys Ala Asp Ala Arg 
        355                 360                 365             


Asp Ile Gly Lys Lys Arg Ser Lys Asp Gly Glu Lys Glu Lys Phe Lys 
    370                 375                 380                 


Phe Ser Leu His Gly Ser Arg Pro Ser Ser Glu Val Gln Tyr Ser Val 
385                 390                 395                 400 


Gln Ser Leu Ser Asp Cys Ser Ser Ala Ile Gln Thr Ser His Met Val 
                405                 410                 415     


Val Tyr Ala Thr Phe Thr Pro Leu Tyr Leu Phe Glu Asn Lys Ile Phe 
            420                 425                 430         


Ser Leu Glu Lys Met Ala Asp Ser Ala Glu Lys Leu Arg Glu Tyr Gly 
        435                 440                 445             


Leu Ser His Ile Cys Ser His Pro Val Leu Val Thr Arg Ser Arg Ser 
    450                 455                 460                 


Cys Pro Leu Val Ala Pro Pro Lys Pro Pro Pro Leu Pro Pro Trp Lys 
465                 470                 475                 480 


Leu Ile Arg Gln Lys Lys Glu Thr Val Ile Thr Asp Glu Ala Gln Glu 
                485                 490                 495     


Leu Ile Val Lys Lys Pro Glu Arg Phe Leu Glu Ile Ser Ser Pro Phe 
            500                 505                 510         


Leu Asn Tyr Arg Met Thr Pro Phe Thr Ile Pro Thr Glu Met His Phe 
        515                 520                 525             


Val Arg Ser Leu Ile Lys Lys Gly Ile Pro Pro Gly Ser Asp Leu Pro 
    530                 535                 540                 


Ser Val Ser Glu Thr Asp Glu Thr Ala Thr His Ser Gln Thr Asp Leu 
545                 550                 555                 560 


Ser Gln Ile Thr Lys Ala Thr Ser Gln Gly Asn Thr Ala Ser Gln Val 
                565                 570                 575     


Ile Leu Gly Lys Gly Thr Asp Glu Gln Thr Asp Phe Gly Leu Gly Asp 
            580                 585                 590         


Ala His Gln Ser Asp Gly Leu Asn Leu Glu Arg Glu Ile Val Ser Gln 
        595                 600                 605             


Thr Thr Ala Thr Gln Glu Lys Ser Gln Glu Glu Leu Pro Thr Thr Asn 
    610                 615                 620                 


Asn Ser Val Ser Lys Glu Ile Trp Leu Asp Phe Glu Asp Phe Cys Val 
625                 630                 635                 640 


Cys Phe Gln Asn Ile Tyr Ile Phe His Lys Pro Ser Ser Tyr Cys Leu 
                645                 650                 655     


Asn Phe Gln Lys Ser Glu Phe Lys Phe Ser Glu Glu Arg Val Ser Tyr 
            660                 665                 670         


Tyr Leu Phe Val Asp Ser Leu Lys Pro Ile Glu Leu Leu Val Cys Phe 
        675                 680                 685             


Ser Ala Leu Val Arg Trp Gly Glu Tyr Gly Ala Leu Thr Lys Asp Ser 
    690                 695                 700                 


Pro Pro Ile Glu Pro Gly Leu Leu Thr Ala Glu Thr Phe Ser Trp Lys 
705                 710                 715                 720 


Ser Leu Lys Pro Gly Ser Leu Val Leu Lys Ile His Thr Tyr Ala Thr 
                725                 730                 735     


Lys Ala Thr Val Val Arg Leu Pro Val Gly Arg His Met Leu Leu Phe 
            740                 745                 750         


Asn Ala Tyr Ser Pro Val Gly His Ser Ile His Ile Cys Ser Met Val 
        755                 760                 765             


Ser Phe Val Ile Gly Asp Glu His Val Val Leu Pro Asn Phe Glu Pro 
    770                 775                 780                 


Glu Ser Cys Arg Phe Thr Glu Gln Ser Leu Leu Ile Met Lys Ala Ile 
785                 790                 795                 800 


Gly Asn Val Ile Ala Asn Phe Lys Asp Lys Gly Lys Leu Ser Ala Ala 
                805                 810                 815     


Leu Lys Asp Leu Gln Thr Ala His Tyr Pro Val Pro Phe His Asp Lys 
            820                 825                 830         


Glu Leu Thr Ala Gln His Phe Arg Val Phe His Leu Ser Leu Trp Arg 
        835                 840                 845             


Leu Met Lys Lys Val Gln Ile Thr Lys Pro Pro Pro Asn Phe Lys Phe 
    850                 855                 860                 


Ala Phe Arg Ala Met Val Leu Asp Leu Glu Leu Leu Asn Ser Ser Leu 
865                 870                 875                 880 


Glu Glu Val Ser Leu Val Glu Trp Leu Asp Val Lys Tyr Cys Met Pro 
                885                 890                 895     


Thr Ser Asp Lys Glu Tyr Ser Ala Glu Glu Val Ala Ala Ala Ile Lys 
            900                 905                 910         


Ile Gln Ala Met Trp Arg Gly Thr Tyr Val Arg Leu Leu Met Lys Ala 
        915                 920                 925             


Arg Ile Pro Asp Thr Lys Glu Asn Ile Ser Val Ala Asp Thr Leu Gln 
    930                 935                 940                 


Lys Val Trp Ala Val Leu Glu Met Asn Leu Glu Gln Tyr Ala Val Ser 
945                 950                 955                 960 


Leu Leu Arg Leu Met Phe Lys Ser Lys Cys Lys Ser Leu Glu Ser Tyr 
                965                 970                 975     


Pro Cys Tyr Gln Asp Glu Glu Thr Lys Ile Ala Phe Ala Asp Tyr Thr 
            980                 985                 990         


Val Thr Tyr Gln Glu Gln Pro Pro  Asn Ser Trp Phe Ile  Val Phe Arg 
        995                 1000                 1005             


Glu Thr  Phe Leu Val His Gln  Asp Met Ile Leu Val  Pro Lys Val 
    1010                 1015                 1020             


Tyr Thr  Thr Leu Pro Ile Cys  Ile Leu His Ile Val  Asn Asn Asp 
    1025                 1030                 1035             


Thr Met  Glu Gln Val Pro Lys  Val Phe Gln Lys Val  Val Pro Tyr 
    1040                 1045                 1050             


Leu Tyr  Thr Lys Asn Lys Lys  Gly Tyr Thr Phe Val  Ala Glu Ala 
    1055                 1060                 1065             


Phe Thr  Gly Asp Thr Tyr Val  Ala Ala Ser Arg Trp  Lys Leu Arg 
    1070                 1075                 1080             


Leu Ile  Gly Ser Ser Ala Pro  Leu Pro Cys Leu Ser  Arg Asp Ser 
    1085                 1090                 1095             


Pro Cys  Asn Ser Phe Ala Ile  Lys Glu Ile Arg Asp  Tyr Tyr Ile 
    1100                 1105                 1110             


Pro Asn  Asp Lys Lys Ile Leu  Phe Arg Tyr Ser Val  Lys Val Leu 
    1115                 1120                 1125             


Thr Pro  Gln Pro Ala Thr Ile  Gln Val Arg Thr Ser  Lys Pro Asp 
    1130                 1135                 1140             


Ala Phe  Ile Lys Leu Gln Val  Leu Glu Asn Glu Glu  Thr Met Val 
    1145                 1150                 1155             


Ser Ser  Thr Gly Lys Gly Gln  Ala Ile Ile Pro Ala  Phe His Phe 
    1160                 1165                 1170             


Leu Lys  Ser Glu Lys Gly Leu  Ser Ser Gln Ser Ser  Lys His Ile 
    1175                 1180                 1185             


Leu Ser  Phe His Ser Ala Ser  Lys Lys Glu Gln Glu  Val Tyr Val 
    1190                 1195                 1200             


Lys Lys  Lys Ala Ala Gln Gly  Ile Gln Lys Ser Pro  Lys Gly Arg 
    1205                 1210                 1215             


Ala Val  Ser Ala Ile Gln Asp  Ile Gly Leu Pro Leu  Val Glu Glu 
    1220                 1225                 1230             


Glu Thr  Thr Ser Thr Pro Thr  Arg Glu Asp Ser Ser  Ser Thr Pro 
    1235                 1240                 1245             


Leu Gln  Asn Tyr Lys Tyr Ile  Ile Gln Cys Ser Val  Leu Tyr Asn 
    1250                 1255                 1260             


Ser Trp  Pro Leu Thr Glu Ser  Gln Leu Thr Phe Val  Gln Ala Leu 
    1265                 1270                 1275             


Lys Asp  Leu Lys Lys Ser Asn  Thr Lys Ala Tyr Gly  Glu Arg His 
    1280                 1285                 1290             


Glu Glu  Leu Ile Asn Leu Gly  Ser Pro Asp Ser His  Thr Ile Ser 
    1295                 1300                 1305             


Glu Gly  Gln Lys Ser Ser Val  Thr Ser Lys Thr Thr  Arg Lys Gly 
    1310                 1315                 1320             


Lys Glu  Lys Ser Ser Glu Lys  Glu Lys Thr Ala Lys  Glu Lys Gln 
    1325                 1330                 1335             


Ala Pro  Arg Phe Glu Pro Gln  Ile Ser Thr Val His  Pro Gln Gln 
    1340                 1345                 1350             


Glu Asp  Pro Asn Lys Pro Tyr  Trp Ile Leu Arg Leu  Val Thr Glu 
    1355                 1360                 1365             


His Asn  Glu Ser Glu Leu Phe  Glu Val Lys Lys Asp  Thr Glu Arg 
    1370                 1375                 1380             


Ala Asp  Glu Ile Arg Ala Met  Lys Gln Ala Trp Glu  Thr Thr Glu 
    1385                 1390                 1395             


Pro Gly  Arg Ala Ile Lys Ala  Ser Gln Ala Arg Leu  His Tyr Leu 
    1400                 1405                 1410             


Ser Gly  Phe Ile Lys Lys Thr  Ser Asp Ala Glu Ser  Pro Pro Ile 
    1415                 1420                 1425             


Ser Glu  Ser Gln Thr Lys Pro  Lys Glu Glu Val Glu  Thr Ala Ala 
    1430                 1435                 1440             


Arg Gly  Val Lys Glu Pro Asn  Ser Lys Asn Ser Ala  Gly Ser Glu 
    1445                 1450                 1455             


Ser Lys  Glu Met Thr Gln Thr  Gly Ser Gly Ser Ala  Val Trp Lys 
    1460                 1465                 1470             


Lys Trp  Gln Leu Thr Lys Gly  Leu Arg Asp Val Ala  Lys Ser Thr 
    1475                 1480                 1485             


Ser Ser  Glu Ser Gly Gly Val  Ser Ser Pro Gly Lys  Glu Glu Arg 
    1490                 1495                 1500             


Glu Gln  Ser Thr Arg Lys Glu  Asn Ile Gln Thr Gly  Pro Arg Thr 
    1505                 1510                 1515             


Arg Ser  Pro Thr Ile Leu Glu  Thr Ser Pro Arg Leu  Ile Arg Lys 
    1520                 1525                 1530             


Ala Leu  Glu Phe Met Asp Leu  Ser Gln Tyr Val Arg  Lys Thr Asp 
    1535                 1540                 1545             


Thr Asp  Pro Leu Leu Gln Thr  Asp Glu Leu Asn Gln  Gln Gln Ala 
    1550                 1555                 1560             


Met Gln  Lys Ala Glu Glu Ile  His Gln Phe Arg Gln  His Arg Thr 
    1565                 1570                 1575             


Arg Val  Leu Ser Ile Arg Asn  Ile Asp Gln Glu Glu  Arg Leu Lys 
    1580                 1585                 1590             


Leu Lys  Asp Glu Val Leu Asp  Met Tyr Lys Glu Met  Gln Asp Ser 
    1595                 1600                 1605             


Leu Asp  Glu Ala Arg Gln Lys  Ile Phe Asp Ile Arg  Glu Glu Tyr 
    1610                 1615                 1620             


Arg Asn  Lys Leu Leu Glu Ala  Glu His Leu Lys Leu  Glu Thr Leu 
    1625                 1630                 1635             


Ala Ala  Gln Glu Ala Ala Met  Lys Leu Glu Thr Glu  Lys Met Thr 
    1640                 1645                 1650             


Pro Ala  Pro Asp Thr Gln Lys  Lys Lys Lys Gly Lys  Lys Lys 
    1655                 1660                 1665         


<210>  255
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRA1__Homo_sapiens__NP_001077378

<400>  255

Met Asp Leu Lys Thr Val Leu Ser Leu Pro Arg Tyr Pro Gly Glu Phe 
1               5                   10                  15      


Leu His Pro Val Val Tyr Ala Cys Thr Ala Val Met Leu Leu Cys Leu 
            20                  25                  30          


Leu Ala Ser Phe Val Thr Tyr Ile Val His Gln Ser Ala Ile Arg Ile 
        35                  40                  45              


Ser Arg Lys Gly Arg His Thr Leu Leu Asn Phe Cys Phe His Ala Ala 
    50                  55                  60                  


Leu Thr Phe Thr Val Phe Ala Gly Gly Ile Asn Arg Thr Lys Tyr Pro 
65                  70                  75                  80  


Ile Leu Cys Gln Ala Val Gly Ile Val Leu His Tyr Ser Thr Leu Ser 
                85                  90                  95      


Thr Met Leu Trp Ile Gly Val Thr Ala Arg Asn Ile Tyr Lys Gln Val 
            100                 105                 110         


Thr Lys Lys Ala Pro Leu Cys Leu Asp Thr Asp Gln Pro Pro Tyr Pro 
        115                 120                 125             


Arg Gln Pro Leu Leu Arg Phe Tyr Leu Val Ser Gly Gly Val Pro Phe 
    130                 135                 140                 


Ile Ile Cys Gly Val Thr Ala Ala Thr Asn Ile Arg Asn Tyr Gly Thr 
145                 150                 155                 160 


Glu Asp Glu Asp Thr Ala Tyr Cys Trp Met Ala Trp Glu Pro Ser Leu 
                165                 170                 175     


Gly Ala Phe Tyr Gly Pro Ala Ala Ile Ile Thr Leu Val Thr Cys Val 
            180                 185                 190         


Tyr Phe Leu Gly Thr Tyr Val Gln Leu Arg Arg His Pro Gly Arg Arg 
        195                 200                 205             


Tyr Glu Leu Arg Thr Gln Pro Glu Glu Gln Arg Arg Leu Ala Thr Pro 
    210                 215                 220                 


Glu Gly Gly Arg Gly Ile Arg Pro Gly Thr Pro Pro Ala His Asp Ala 
225                 230                 235                 240 


Pro Gly Ala Ser Val Leu Gln Asn Glu His Ser Phe Gln Ala Gln Leu 
                245                 250                 255     


Arg Ala Ala Ala Phe Thr Leu Phe Leu Phe Thr Ala Thr Trp Ala Phe 
            260                 265                 270         


Gly Ala Leu Ala Val Ser Gln Gly His Phe Leu Asp Met Val Phe Ser 
        275                 280                 285             


Cys Leu Tyr Gly Ala Phe Cys Val Thr Leu Gly Leu Phe Val Leu Ile 
    290                 295                 300                 


His His Cys Ala Lys Arg Glu Asp Val Trp Gln Cys Trp Trp Ala Cys 
305                 310                 315                 320 


Cys Pro Pro Arg Lys Asp Ala His Pro Ala Leu Asp Ala Asn Gly Ala 
                325                 330                 335     


Ala Leu Gly Arg Ala Ala Cys Leu His Ser Pro Gly Leu Gly Gln Pro 
            340                 345                 350         


Arg Gly Phe Ala His Pro Pro Gly Pro Cys Lys Met Thr Asn Leu Gln 
        355                 360                 365             


Ala Ala Gln Gly His Ala Ser Cys Leu Ser Pro Ala Thr Pro Cys Cys 
    370                 375                 380                 


Ala Lys Met His Cys Glu Pro Leu Thr Ala Asp Glu Ala His Val His 
385                 390                 395                 400 


Leu Gln Glu Glu Gly Ala Phe Gly His Asp Pro His Leu His Gly Cys 
                405                 410                 415     


Leu Gln Gly Arg Thr Lys Pro Pro Tyr Phe Ser Arg His Pro Ala Glu 
            420                 425                 430         


Glu Pro Glu Tyr Ala Tyr His Ile Pro Ser Ser Leu Asp Gly Ser Pro 
        435                 440                 445             


Arg Ser Ser Arg Thr Asp Ser Pro Pro Ser Ser Leu Asp Gly Pro Ala 
    450                 455                 460                 


Gly Thr His Thr Leu Ala Cys Cys Thr Gln Gly Asp Pro Phe Pro Met 
465                 470                 475                 480 


Val Thr Gln Pro Glu Gly Ser Asp Gly Ser Pro Ala Leu Tyr Ser Cys 
                485                 490                 495     


Pro Thr Gln Pro Gly Arg Glu Ala Ala Leu Gly Pro Gly His Leu Glu 
            500                 505                 510         


Met Leu Arg Arg Thr Gln Ser Leu Pro Phe Gly Gly Pro Ser Gln Asn 
        515                 520                 525             


Gly Leu Pro Lys Gly Lys Leu Leu Glu Gly Leu Pro Phe Gly Thr Asp 
    530                 535                 540                 


Gly Thr Gly Asn Ile Arg Thr Gly Pro Trp Lys Asn Glu Thr Thr Val 
545                 550                 555                 560 


<210>  256
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRA2__Homo_sapiens__NP_116166

<400>  256

Met Gly Ala Gly Gly Arg Arg Met Arg Gly Ala Pro Ala Arg Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Trp Leu Leu Leu Leu Leu Ala Pro Glu Ala Arg 
            20                  25                  30          


Gly Ala Pro Gly Cys Pro Leu Ser Ile Arg Ser Cys Lys Cys Ser Gly 
        35                  40                  45              


Glu Arg Pro Lys Gly Leu Ser Gly Gly Val Pro Gly Pro Ala Arg Arg 
    50                  55                  60                  


Arg Val Val Cys Ser Gly Gly Asp Leu Pro Glu Pro Pro Glu Pro Gly 
65                  70                  75                  80  


Leu Leu Pro Asn Gly Thr Val Thr Leu Leu Leu Ser Asn Asn Lys Ile 
                85                  90                  95      


Thr Gly Leu Arg Asn Gly Ser Phe Leu Gly Leu Ser Leu Leu Glu Lys 
            100                 105                 110         


Leu Asp Leu Arg Asn Asn Ile Ile Ser Thr Val Gln Pro Gly Ala Phe 
        115                 120                 125             


Leu Gly Leu Gly Glu Leu Lys Arg Leu Asp Leu Ser Asn Asn Arg Ile 
    130                 135                 140                 


Gly Cys Leu Thr Ser Glu Thr Phe Gln Gly Leu Pro Arg Leu Leu Arg 
145                 150                 155                 160 


Leu Asn Ile Ser Gly Asn Ile Phe Ser Ser Leu Gln Pro Gly Val Phe 
                165                 170                 175     


Asp Glu Leu Pro Ala Leu Lys Val Val Asp Leu Gly Thr Glu Phe Leu 
            180                 185                 190         


Thr Cys Asp Cys His Leu Arg Trp Leu Leu Pro Trp Ala Gln Asn Arg 
        195                 200                 205             


Ser Leu Gln Leu Ser Glu His Thr Leu Cys Ala Tyr Pro Ser Ala Leu 
    210                 215                 220                 


His Ala Gln Ala Leu Gly Ser Leu Gln Glu Ala Gln Leu Cys Cys Glu 
225                 230                 235                 240 


Gly Ala Leu Glu Leu His Thr His His Leu Ile Pro Ser Leu Arg Gln 
                245                 250                 255     


Val Val Phe Gln Gly Asp Arg Leu Pro Phe Gln Cys Ser Ala Ser Tyr 
            260                 265                 270         


Leu Gly Asn Asp Thr Arg Ile Arg Trp Tyr His Asn Arg Ala Pro Val 
        275                 280                 285             


Glu Gly Asp Glu Gln Ala Gly Ile Leu Leu Ala Glu Ser Leu Ile His 
    290                 295                 300                 


Asp Cys Thr Phe Ile Thr Ser Glu Leu Thr Leu Ser His Ile Gly Val 
305                 310                 315                 320 


Trp Ala Ser Gly Glu Trp Glu Cys Thr Val Ser Met Ala Gln Gly Asn 
                325                 330                 335     


Ala Ser Lys Lys Val Glu Ile Val Val Leu Glu Thr Ser Ala Ser Tyr 
            340                 345                 350         


Cys Pro Ala Glu Arg Val Ala Asn Asn Arg Gly Asp Phe Arg Trp Pro 
        355                 360                 365             


Arg Thr Leu Ala Gly Ile Thr Ala Tyr Gln Ser Cys Leu Gln Tyr Pro 
    370                 375                 380                 


Phe Thr Ser Val Pro Leu Gly Gly Gly Ala Pro Gly Thr Arg Ala Ser 
385                 390                 395                 400 


Arg Arg Cys Asp Arg Ala Gly Arg Trp Glu Pro Gly Asp Tyr Ser His 
                405                 410                 415     


Cys Leu Tyr Thr Asn Asp Ile Thr Arg Val Leu Tyr Thr Phe Val Leu 
            420                 425                 430         


Met Pro Ile Asn Ala Ser Asn Ala Leu Thr Leu Ala His Gln Leu Arg 
        435                 440                 445             


Val Tyr Thr Ala Glu Ala Ala Ser Phe Ser Asp Met Met Asp Val Val 
    450                 455                 460                 


Tyr Val Ala Gln Met Ile Gln Lys Phe Leu Gly Tyr Val Asp Gln Ile 
465                 470                 475                 480 


Lys Glu Leu Val Glu Val Met Val Asp Met Ala Ser Asn Leu Met Leu 
                485                 490                 495     


Val Asp Glu His Leu Leu Trp Leu Ala Gln Arg Glu Asp Lys Ala Cys 
            500                 505                 510         


Ser Arg Ile Val Gly Ala Leu Glu Arg Ile Gly Gly Ala Ala Leu Ser 
        515                 520                 525             


Pro His Ala Gln His Ile Ser Val Asn Ala Arg Asn Val Ala Leu Glu 
    530                 535                 540                 


Ala Tyr Leu Ile Lys Pro His Ser Tyr Val Gly Leu Thr Cys Thr Ala 
545                 550                 555                 560 


Phe Gln Arg Arg Glu Gly Gly Val Pro Gly Thr Arg Pro Gly Ser Pro 
                565                 570                 575     


Gly Gln Asn Pro Pro Pro Glu Pro Glu Pro Pro Ala Asp Gln Gln Leu 
            580                 585                 590         


Arg Phe Arg Cys Thr Thr Gly Arg Pro Asn Val Ser Leu Ser Ser Phe 
        595                 600                 605             


His Ile Lys Asn Ser Val Ala Leu Ala Ser Ile Gln Leu Pro Pro Ser 
    610                 615                 620                 


Leu Phe Ser Ser Leu Pro Ala Ala Leu Ala Pro Pro Val Pro Pro Asp 
625                 630                 635                 640 


Cys Thr Leu Gln Leu Leu Val Phe Arg Asn Gly Arg Leu Phe His Ser 
                645                 650                 655     


His Ser Asn Thr Ser Arg Pro Gly Ala Ala Gly Pro Gly Lys Arg Arg 
            660                 665                 670         


Gly Val Ala Thr Pro Val Ile Phe Ala Gly Thr Ser Gly Cys Gly Val 
        675                 680                 685             


Gly Asn Leu Thr Glu Pro Val Ala Val Ser Leu Arg His Trp Ala Glu 
    690                 695                 700                 


Gly Ala Glu Pro Val Ala Ala Trp Trp Ser Gln Glu Gly Pro Gly Glu 
705                 710                 715                 720 


Ala Gly Gly Trp Thr Ser Glu Gly Cys Gln Leu Arg Ser Ser Gln Pro 
                725                 730                 735     


Asn Val Ser Ala Leu His Cys Gln His Leu Gly Asn Val Ala Val Leu 
            740                 745                 750         


Met Glu Leu Ser Ala Phe Pro Arg Glu Val Gly Gly Ala Gly Ala Gly 
        755                 760                 765             


Leu His Pro Val Val Tyr Pro Cys Thr Ala Leu Leu Leu Leu Cys Leu 
    770                 775                 780                 


Phe Ala Thr Ile Ile Thr Tyr Ile Leu Asn His Ser Ser Ile Arg Val 
785                 790                 795                 800 


Ser Arg Lys Gly Trp His Met Leu Leu Asn Leu Cys Phe His Ile Ala 
                805                 810                 815     


Met Thr Ser Ala Val Phe Ala Gly Gly Ile Thr Leu Thr Asn Tyr Gln 
            820                 825                 830         


Met Val Cys Gln Ala Val Gly Ile Thr Leu His Tyr Ser Ser Leu Ser 
        835                 840                 845             


Thr Leu Leu Trp Met Gly Val Lys Ala Arg Val Leu His Lys Glu Leu 
    850                 855                 860                 


Thr Trp Arg Ala Pro Pro Pro Gln Glu Gly Asp Pro Ala Leu Pro Thr 
865                 870                 875                 880 


Pro Ser Pro Met Leu Arg Phe Tyr Leu Ile Ala Gly Gly Ile Pro Leu 
                885                 890                 895     


Ile Ile Cys Gly Ile Thr Ala Ala Val Asn Ile His Asn Tyr Arg Asp 
            900                 905                 910         


His Ser Pro Tyr Cys Trp Leu Val Trp Arg Pro Ser Leu Gly Ala Phe 
        915                 920                 925             


Tyr Ile Pro Val Ala Leu Ile Leu Leu Ile Thr Trp Ile Tyr Phe Leu 
    930                 935                 940                 


Cys Ala Gly Leu Arg Leu Arg Gly Pro Leu Ala Gln Asn Pro Lys Ala 
945                 950                 955                 960 


Gly Asn Ser Arg Ala Ser Leu Glu Ala Gly Glu Glu Leu Arg Gly Ser 
                965                 970                 975     


Thr Arg Leu Arg Gly Ser Gly Pro Leu Leu Ser Asp Ser Gly Ser Leu 
            980                 985                 990         


Leu Ala Thr Gly Ser Ala Arg Val  Gly Thr Pro Gly Pro  Pro Glu Asp 
        995                 1000                 1005             


Gly Asp  Ser Leu Tyr Ser Pro  Gly Val Gln Leu Gly  Ala Leu Val 
    1010                 1015                 1020             


Thr Thr  His Phe Leu Tyr Leu  Ala Met Trp Ala Cys  Gly Ala Leu 
    1025                 1030                 1035             


Ala Val  Ser Gln Arg Trp Leu  Pro Arg Val Val Cys  Ser Cys Leu 
    1040                 1045                 1050             


Tyr Gly  Val Ala Ala Ser Ala  Leu Gly Leu Phe Val  Phe Thr His 
    1055                 1060                 1065             


His Cys  Ala Arg Arg Arg Asp  Val Arg Ala Ser Trp  Arg Ala Cys 
    1070                 1075                 1080             


Cys Pro  Pro Ala Ser Pro Ala  Ala Pro His Ala Pro  Pro Arg Ala 
    1085                 1090                 1095             


Leu Pro  Ala Ala Ala Glu Asp  Gly Ser Pro Val Phe  Gly Glu Gly 
    1100                 1105                 1110             


Pro Pro  Ser Leu Lys Ser Ser  Pro Ser Gly Ser Ser  Gly His Pro 
    1115                 1120                 1125             


Leu Ala  Leu Gly Pro Cys Lys  Leu Thr Asn Leu Gln  Leu Ala Gln 
    1130                 1135                 1140             


Ser Gln  Val Cys Glu Ala Gly  Ala Ala Ala Gly Gly  Glu Gly Glu 
    1145                 1150                 1155             


Pro Glu  Pro Ala Gly Thr Arg  Gly Asn Leu Ala His  Arg His Pro 
    1160                 1165                 1170             


Asn Asn  Val His His Gly Arg  Arg Ala His Lys Ser  Arg Ala Lys 
    1175                 1180                 1185             


Gly His  Arg Ala Gly Glu Ala  Cys Gly Lys Asn Arg  Leu Lys Ala 
    1190                 1195                 1200             


Leu Arg  Gly Gly Ala Ala Gly  Ala Leu Glu Leu Leu  Ser Ser Glu 
    1205                 1210                 1215             


Ser Gly  Ser Leu His Asn Ser  Pro Thr Asp Ser Tyr  Leu Gly Ser 
    1220                 1225                 1230             


Ser Arg  Asn Ser Pro Gly Ala  Gly Leu Gln Leu Glu  Gly Glu Pro 
    1235                 1240                 1245             


Met Leu  Thr Pro Ser Glu Gly  Ser Asp Thr Ser Ala  Ala Pro Leu 
    1250                 1255                 1260             


Ser Glu  Ala Gly Arg Ala Gly  Gln Arg Arg Ser Ala  Ser Arg Asp 
    1265                 1270                 1275             


Ser Leu  Lys Gly Gly Gly Ala  Leu Glu Lys Glu Ser  His Arg Arg 
    1280                 1285                 1290             


Ser Tyr  Pro Leu Asn Ala Ala  Ser Leu Asn Gly Ala  Pro Lys Gly 
    1295                 1300                 1305             


Gly Lys  Tyr Asp Asp Val Thr  Leu Met Gly Ala Glu  Val Ala Ser 
    1310                 1315                 1320             


Gly Gly  Cys Met Lys Thr Gly  Leu Trp Lys Ser Glu  Thr Thr Val 
    1325                 1330                 1335             


<210>  257
<211>  1321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRA3__Homo_sapiens__NP_660333

<400>  257

Met Glu Pro Pro Gly Arg Arg Arg Gly Arg Ala Gln Pro Pro Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Ala Leu Leu Ala Leu Leu Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ala Ala Ala Leu Pro Ala Gly Cys Lys His Asp Gly Arg 
        35                  40                  45              


Pro Arg Gly Ala Gly Arg Ala Ala Gly Ala Ala Glu Gly Lys Val Val 
    50                  55                  60                  


Cys Ser Ser Leu Glu Leu Ala Gln Val Leu Pro Pro Asp Thr Leu Pro 
65                  70                  75                  80  


Asn Arg Thr Val Thr Leu Ile Leu Ser Asn Asn Lys Ile Ser Glu Leu 
                85                  90                  95      


Lys Asn Gly Ser Phe Ser Gly Leu Ser Leu Leu Glu Arg Leu Asp Leu 
            100                 105                 110         


Arg Asn Asn Leu Ile Ser Ser Ile Asp Pro Gly Ala Phe Trp Gly Leu 
        115                 120                 125             


Ser Ser Leu Lys Arg Leu Asp Leu Thr Asn Asn Arg Ile Gly Cys Leu 
    130                 135                 140                 


Asn Ala Asp Ile Phe Arg Gly Leu Thr Asn Leu Val Arg Leu Asn Leu 
145                 150                 155                 160 


Ser Gly Asn Leu Phe Ser Ser Leu Ser Gln Gly Thr Phe Asp Tyr Leu 
                165                 170                 175     


Ala Ser Leu Arg Ser Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp 
            180                 185                 190         


Cys Asn Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr 
        195                 200                 205             


Val Arg Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro 
    210                 215                 220                 


Val Thr Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu 
225                 230                 235                 240 


Leu Pro Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu 
                245                 250                 255     


Gly Asp Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp 
            260                 265                 270         


Met Gln Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu 
        275                 280                 285             


Ser Gln Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu 
    290                 295                 300                 


Ile Ala Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly 
305                 310                 315                 320 


Asn Trp Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr 
                325                 330                 335     


Val Asp Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu 
            340                 345                 350         


Arg Val Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala 
        355                 360                 365             


Gly Ile Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly 
    370                 375                 380                 


Ile Tyr Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr 
                405                 410                 415     


Ala Asn Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu 
            420                 425                 430         


Asn Leu Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr 
        435                 440                 445             


Val Glu Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala 
    450                 455                 460                 


Glu Met Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys 
465                 470                 475                 480 


Glu Leu Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala 
                485                 490                 495     


Asp Glu Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser 
            500                 505                 510         


Arg Ile Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly 
        515                 520                 525             


Gly Ala His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala 
    530                 535                 540                 


Tyr Val Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe 
545                 550                 555                 560 


Gln Lys Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg 
                565                 570                 575     


Arg Asp Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn 
            580                 585                 590         


Val Ser Asn Thr Phe Ser Ser Leu Ala Leu Lys Asn Thr Ile Val Glu 
        595                 600                 605             


Ala Ser Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg 
    610                 615                 620                 


Glu Leu Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala 
625                 630                 635                 640 


Phe Arg Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu 
                645                 650                 655     


Ala Asp Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu Thr 
            660                 665                 670         


Lys Ile Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn Val 
        675                 680                 685             


Thr Leu Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp 
    690                 695                 700                 


Asp Phe Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys 
705                 710                 715                 720 


His Ile Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr Ser 
                725                 730                 735     


Leu Ser Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu Tyr 
            740                 745                 750         


Thr Gln Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala Ile 
        755                 760                 765             


Ile Leu Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His 
    770                 775                 780                 


His Ser Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn 
785                 790                 795                 800 


Leu Cys Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly Ile 
                805                 810                 815     


Thr Gln Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu 
            820                 825                 830         


His Tyr Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala Arg 
        835                 840                 845             


Asn Ile Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp Pro 
    850                 855                 860                 


Asp Glu Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile 
865                 870                 875                 880 


Gly Gly Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala Asn 
                885                 890                 895     


Ile Lys Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala 
            900                 905                 910         


Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ser Phe Ile Thr 
        915                 920                 925             


Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg 
    930                 935                 940                 


His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Glu Gln Gln 
945                 950                 955                 960 


Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn His Gln Asp Ser Met 
                965                 970                 975     


Ser Leu Ser Leu Ile Ser Thr Ser Ala Leu Glu Asn Glu His Thr Phe 
            980                 985                 990         


His Ser Gln Leu Leu Gly Ala Ser  Leu Thr Leu Leu Leu  Tyr Val Ala 
        995                 1000                 1005             


Leu Trp  Met Phe Gly Ala Leu  Ala Val Ser Leu Tyr  Tyr Pro Leu 
    1010                 1015                 1020             


Asp Leu  Val Phe Ser Phe Val  Phe Gly Ala Thr Ser  Leu Ser Phe 
    1025                 1030                 1035             


Ser Ala  Phe Phe Val Val His  His Cys Val Asn Arg  Glu Asp Val 
    1040                 1045                 1050             


Arg Leu  Ala Trp Ile Met Thr  Cys Cys Pro Gly Arg  Ser Ser Tyr 
    1055                 1060                 1065             


Ser Val  Gln Val Asn Val Gln  Pro Pro Asn Ser Asn  Gly Thr Asn 
    1070                 1075                 1080             


Gly Glu  Ala Pro Lys Cys Pro  Asn Ser Ser Ala Glu  Ser Ser Cys 
    1085                 1090                 1095             


Thr Asn  Lys Ser Ala Ser Ser  Phe Lys Asn Ser Ser  Gln Gly Cys 
    1100                 1105                 1110             


Lys Leu  Thr Asn Leu Gln Ala  Ala Ala Ala Gln Cys  His Ala Asn 
    1115                 1120                 1125             


Ser Leu  Pro Leu Asn Ser Thr  Pro Gln Leu Asp Asn  Ser Leu Thr 
    1130                 1135                 1140             


Glu His  Ser Met Asp Asn Asp  Ile Lys Met His Val  Ala Pro Leu 
    1145                 1150                 1155             


Glu Val  Gln Phe Arg Thr Asn  Val His Ser Ser Arg  His His Lys 
    1160                 1165                 1170             


Asn Arg  Ser Lys Gly His Arg  Ala Ser Arg Leu Thr  Val Leu Arg 
    1175                 1180                 1185             


Glu Tyr  Ala Tyr Asp Val Pro  Thr Ser Val Glu Gly  Ser Val Gln 
    1190                 1195                 1200             


Asn Gly  Leu Pro Lys Ser Arg  Leu Gly Asn Asn Glu  Gly His Ser 
    1205                 1210                 1215             


Arg Ser  Arg Arg Ala Tyr Leu  Ala Tyr Arg Glu Arg  Gln Tyr Asn 
    1220                 1225                 1230             


Pro Pro  Gln Gln Asp Ser Ser  Asp Ala Cys Ser Thr  Leu Pro Lys 
    1235                 1240                 1245             


Ser Ser  Arg Asn Phe Glu Lys  Pro Val Ser Thr Thr  Ser Lys Lys 
    1250                 1255                 1260             


Asp Ala  Leu Arg Lys Pro Ala  Val Val Glu Leu Glu  Asn Gln Gln 
    1265                 1270                 1275             


Lys Ser  Tyr Gly Leu Asn Leu  Ala Ile Gln Asn Gly  Pro Ile Lys 
    1280                 1285                 1290             


Ser Asn  Gly Gln Glu Gly Pro  Leu Leu Gly Thr Asp  Ser Thr Gly 
    1295                 1300                 1305             


Asn Val  Arg Thr Gly Leu Trp  Lys His Glu Thr Thr  Val 
    1310                 1315                 1320     


<210>  258
<211>  1584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRB1__Homo_sapiens__XP_011515501

<400>  258

Met Arg Gly Gln Ala Ala Ala Pro Gly Pro Val Trp Ile Leu Ala Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Gly Arg Arg Ala Arg Ala Ala Ala 
            20                  25                  30          


Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu Val Gln 
        35                  40                  45              


Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro Ala Asn 
    50                  55                  60                  


Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg Arg Tyr 
65                  70                  75                  80  


Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser Gly Pro 
                85                  90                  95      


Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser Thr Arg 
            100                 105                 110         


Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu Cys Asp 
        115                 120                 125             


Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe Leu Gln 
    130                 135                 140                 


Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro Arg Ala 
145                 150                 155                 160 


Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu Val Val 
                165                 170                 175     


Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys Arg Trp 
            180                 185                 190         


Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys Gly Ile 
        195                 200                 205             


Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly Pro Ala 
    210                 215                 220                 


Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp Ala Val 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp Arg Gly 
                245                 250                 255     


Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp Gly Glu 
            260                 265                 270         


Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg Thr Cys 
        275                 280                 285             


Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val Leu Glu 
    290                 295                 300                 


Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly Arg Thr 
305                 310                 315                 320 


Ser Ser Arg Ser Gln Ser Leu Arg Ser Thr Asp Ala Arg Arg Arg Glu 
                325                 330                 335     


Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro Gln Thr 
            340                 345                 350         


Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys Ser Ser 
        355                 360                 365             


Thr Cys Gly Glu Gly Trp Gln Thr Arg Thr Arg Phe Cys Val Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Thr Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg Leu Cys 
385                 390                 395                 400 


Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu Trp Ser 
                405                 410                 415     


Pro Trp Ser Leu Cys Ser Ser Thr Cys Gly Arg Gly Phe Arg Asp Arg 
            420                 425                 430         


Thr Arg Thr Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys Glu Gly 
        435                 440                 445             


Pro Glu Lys Gln Thr Lys Phe Cys Asn Ile Ala Leu Cys Pro Gly Arg 
    450                 455                 460                 


Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala Cys Ser 
465                 470                 475                 480 


Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Thr Arg Glu Cys Asn Gly 
                485                 490                 495     


Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu Thr Arg 
            500                 505                 510         


Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln Ala Trp 
        515                 520                 525             


Ala Ser Trp Gly Ser Cys Ser Val Thr Cys Gly Ala Gly Ser Gln Arg 
    530                 535                 540                 


Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala Cys Gln 
545                 550                 555                 560 


Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Thr Gln Arg Cys Pro Glu 
                565                 570                 575     


Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile Trp Lys 
            580                 585                 590         


Glu Thr Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg Asn Ala 
        595                 600                 605             


Thr Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly Ile Ala 
    610                 615                 620                 


Tyr Trp Glu Pro Pro Thr Tyr Ile Arg Cys Val Ser Ile Asp Tyr Arg 
625                 630                 635                 640 


Asn Ile Gln Met Met Thr Arg Glu His Leu Ala Lys Ala Gln Arg Gly 
                645                 650                 655     


Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Thr Leu Val Glu Ile 
            660                 665                 670         


Ser Gln Asp Gly Thr Ser Tyr Ser Gly Asp Leu Leu Ser Thr Ile Asp 
        675                 680                 685             


Val Leu Arg Asn Met Thr Glu Ile Phe Arg Arg Ala Tyr Tyr Ser Pro 
    690                 695                 700                 


Thr Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn Leu Leu 
705                 710                 715                 720 


Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala Gly Pro 
                725                 730                 735     


Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp Val Ile 
            740                 745                 750         


Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Thr Asp Asn 
        755                 760                 765             


Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Thr Asp Ile 
    770                 775                 780                 


Ser Phe Pro Met Lys Gly Trp Arg Ala Thr Gly Asp Trp Ala Lys Val 
785                 790                 795                 800 


Pro Glu Asp Arg Val Thr Val Ser Lys Ser Val Phe Ser Thr Gly Leu 
                805                 810                 815     


Thr Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Thr Val Leu Tyr 
            820                 825                 830         


Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Thr Thr Val Leu 
        835                 840                 845             


Asn Ser Lys Val Ile Ser Val Thr Val Lys Pro Pro Pro Arg Ser Leu 
    850                 855                 860                 


Arg Thr Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly Thr Thr 
865                 870                 875                 880 


Asn Gln Thr Cys Ile Leu Trp Asp Glu Thr Asp Val Pro Ser Ser Ser 
                885                 890                 895     


Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg Thr Val 
            900                 905                 910         


Pro Leu Asp Ala Leu Arg Thr Arg Cys Leu Cys Asp Arg Leu Ser Thr 
        915                 920                 925             


Phe Ala Ile Leu Ala Gln Leu Ser Ala Asp Ala Asn Met Glu Lys Ala 
    930                 935                 940                 


Thr Leu Pro Ser Val Thr Leu Ile Val Gly Cys Gly Val Ser Ser Leu 
945                 950                 955                 960 


Thr Leu Leu Met Leu Val Ile Ile Tyr Val Ser Val Trp Arg Tyr Ile 
                965                 970                 975     


Arg Ser Glu Arg Ser Val Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile 
            980                 985                 990         


Ser Ser Asn Ala Leu Ile Leu Ile  Gly Gln Thr Gln Thr  Arg Asn Lys 
        995                 1000                 1005             


Val Val  Cys Thr Leu Val Ala  Ala Phe Leu His Phe  Phe Phe Leu 
    1010                 1015                 1020             


Ser Ser  Phe Cys Trp Val Leu  Thr Glu Ala Trp Gln  Ser Tyr Met 
    1025                 1030                 1035             


Ala Val  Thr Gly His Leu Arg  Asn Arg Leu Ile Arg  Lys Arg Phe 
    1040                 1045                 1050             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Ile Ser 
    1055                 1060                 1065             


Val Gly  Phe Thr Lys Ala Lys  Gly Tyr Ser Thr Met  Asn Tyr Cys 
    1070                 1075                 1080             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1085                 1090                 1095             


Ala Ala  Ala Val Val Leu Val  Asn Met Val Ile Gly  Ile Leu Val 
    1100                 1105                 1110             


Phe Asn  Lys Leu Val Ser Lys  Asp Gly Ile Thr Asp  Lys Lys Leu 
    1115                 1120                 1125             


Lys Glu  Arg Ala Gly Ala Ser  Leu Trp Ser Ser Cys  Val Val Leu 
    1130                 1135                 1140             


Pro Leu  Leu Ala Leu Thr Trp  Met Ser Ala Val Leu  Ala Val Thr 
    1145                 1150                 1155             


Asp Arg  Arg Ser Ala Leu Phe  Gln Ile Leu Phe Ala  Val Phe Asp 
    1160                 1165                 1170             


Ser Leu  Glu Gly Phe Val Ile  Val Met Val His Cys  Ile Leu Arg 
    1175                 1180                 1185             


Arg Glu  Val Gln Asp Ala Val  Lys Cys Arg Val Val  Asp Arg Gln 
    1190                 1195                 1200             


Glu Glu  Gly Asn Gly Asp Ser  Gly Gly Ser Phe Gln  Asn Gly His 
    1205                 1210                 1215             


Ala Gln  Leu Met Thr Asp Phe  Glu Lys Asp Val Asp  Leu Ala Cys 
    1220                 1225                 1230             


Arg Ser  Val Leu Asn Lys Asp  Ile Ala Ala Cys Arg  Thr Ala Thr 
    1235                 1240                 1245             


Ile Thr  Gly Thr Leu Lys Arg  Pro Ser Leu Pro Glu  Glu Glu Lys 
    1250                 1255                 1260             


Leu Lys  Leu Ala His Ala Lys  Gly Pro Pro Thr Asn  Phe Asn Ser 
    1265                 1270                 1275             


Leu Pro  Ala Asn Val Ser Lys  Leu His Leu His Gly  Ser Pro Arg 
    1280                 1285                 1290             


Tyr Pro  Gly Gly Pro Leu Pro  Asp Phe Pro Asn His  Ser Leu Thr 
    1295                 1300                 1305             


Leu Lys  Arg Asp Lys Ala Pro  Lys Ser Ser Phe Val  Gly Asp Gly 
    1310                 1315                 1320             


Asp Ile  Phe Lys Lys Leu Asp  Ser Glu Leu Ser Arg  Ala Gln Glu 
    1325                 1330                 1335             


Lys Ala  Leu Asp Thr Ser Tyr  Val Ile Leu Pro Thr  Ala Thr Ala 
    1340                 1345                 1350             


Thr Leu  Arg Pro Lys Pro Lys  Glu Glu Pro Lys Tyr  Ser Ile His 
    1355                 1360                 1365             


Ile Asp  Gln Met Pro Gln Thr  Arg Leu Ile His Leu  Ser Thr Ala 
    1370                 1375                 1380             


Pro Glu  Ala Ser Leu Pro Ala  Arg Ser Pro Pro Ser  Arg Gln Pro 
    1385                 1390                 1395             


Pro Ser  Gly Gly Pro Pro Glu  Ala Pro Pro Ala Gln  Pro Pro Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Gln Gln Pro  Leu Pro Pro 
    1415                 1420                 1425             


Pro Pro  Asn Leu Glu Pro Ala  Pro Pro Ser Leu Gly  Asp Pro Gly 
    1430                 1435                 1440             


Glu Pro  Ala Ala His Pro Gly  Pro Ser Thr Gly Pro  Ser Thr Lys 
    1445                 1450                 1455             


Asn Glu  Asn Val Ala Thr Leu  Ser Val Ser Ser Leu  Glu Arg Arg 
    1460                 1465                 1470             


Lys Ser  Arg Tyr Ala Glu Leu  Asp Phe Glu Lys Ile  Met His Thr 
    1475                 1480                 1485             


Arg Lys  Arg His Gln Asp Met  Phe Gln Asp Leu Asn  Arg Lys Leu 
    1490                 1495                 1500             


Gln His  Ala Ala Glu Lys Asp  Lys Glu Val Leu Gly  Pro Asp Ser 
    1505                 1510                 1515             


Lys Pro  Glu Lys Gln Gln Thr  Pro Asn Lys Arg Pro  Trp Glu Ser 
    1520                 1525                 1530             


Leu Arg  Lys Ala His Gly Thr  Pro Thr Trp Val Lys  Lys Glu Leu 
    1535                 1540                 1545             


Glu Pro  Leu Gln Pro Ser Pro  Leu Glu Leu Arg Ser  Val Glu Trp 
    1550                 1555                 1560             


Glu Arg  Ser Gly Ala Thr Ile  Pro Leu Val Gly Gln  Asp Ile Ile 
    1565                 1570                 1575             


Asp Leu  Gln Thr Glu Val 
    1580                 


<210>  259
<211>  1584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRB2__Homo_sapiens__NP_001281264

<400>  259

Met Glu Asn Thr Gly Trp Met Gly Lys Gly His Arg Met Thr Pro Ala 
1               5                   10                  15      


Cys Pro Leu Leu Leu Ser Val Ile Leu Ser Leu Arg Leu Ala Thr Ala 
            20                  25                  30          


Phe Asp Pro Ala Pro Ser Ala Cys Ser Ala Leu Ala Ser Gly Val Leu 
        35                  40                  45              


Tyr Gly Ala Phe Ser Leu Gln Asp Leu Phe Pro Thr Ile Ala Ser Gly 
    50                  55                  60                  


Cys Ser Trp Thr Leu Glu Asn Pro Asp Pro Thr Lys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Phe Asn Arg Gln Glu Gln Val Cys Ala His Phe Ala Pro Arg 
                85                  90                  95      


Leu Leu Pro Leu Asp His Tyr Leu Val Asn Phe Thr Cys Leu Arg Pro 
            100                 105                 110         


Ser Pro Glu Glu Ala Val Ala Gln Ala Glu Ser Glu Val Gly Arg Pro 
        115                 120                 125             


Glu Glu Glu Glu Ala Glu Ala Ala Ala Gly Leu Glu Leu Cys Ser Gly 
    130                 135                 140                 


Ser Gly Pro Phe Thr Phe Leu His Phe Asp Lys Asn Phe Val Gln Leu 
145                 150                 155                 160 


Cys Leu Ser Ala Glu Pro Ser Glu Ala Pro Arg Leu Leu Ala Pro Ala 
                165                 170                 175     


Ala Leu Ala Phe Arg Phe Val Glu Val Leu Leu Ile Asn Asn Asn Asn 
            180                 185                 190         


Ser Ser Gln Phe Thr Cys Gly Val Leu Cys Arg Trp Ser Glu Glu Cys 
        195                 200                 205             


Gly Arg Ala Ala Gly Arg Ala Cys Gly Phe Ala Gln Pro Gly Cys Ser 
    210                 215                 220                 


Cys Pro Gly Glu Ala Gly Ala Gly Ser Thr Thr Thr Thr Ser Pro Gly 
225                 230                 235                 240 


Pro Pro Ala Ala His Thr Leu Ser Asn Ala Leu Val Pro Gly Gly Pro 
                245                 250                 255     


Ala Pro Pro Ala Glu Ala Asp Leu His Ser Gly Ser Ser Asn Asp Leu 
            260                 265                 270         


Phe Thr Thr Glu Met Arg Tyr Gly Glu Glu Pro Glu Glu Glu Pro Lys 
        275                 280                 285             


Val Lys Thr Gln Trp Pro Arg Ser Ala Asp Glu Pro Gly Leu Tyr Met 
    290                 295                 300                 


Ala Gln Thr Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val 
305                 310                 315                 320 


Cys Ser Leu Thr Cys Gly Gln Gly Leu Gln Val Arg Thr Arg Ser Cys 
                325                 330                 335     


Val Ser Ser Pro Tyr Gly Thr Leu Cys Ser Gly Pro Leu Arg Glu Thr 
            340                 345                 350         


Arg Pro Cys Asn Asn Ser Ala Thr Cys Pro Val His Gly Val Trp Glu 
        355                 360                 365             


Glu Trp Gly Ser Trp Ser Leu Cys Ser Arg Ser Cys Gly Arg Gly Ser 
    370                 375                 380                 


Arg Ser Arg Met Arg Thr Cys Val Pro Pro Gln His Gly Gly Lys Ala 
385                 390                 395                 400 


Cys Glu Gly Pro Glu Leu Gln Thr Lys Leu Cys Ser Met Ala Ala Cys 
                405                 410                 415     


Pro Val Glu Gly Gln Trp Leu Glu Trp Gly Pro Trp Gly Pro Cys Ser 
            420                 425                 430         


Thr Ser Cys Ala Asn Gly Thr Gln Gln Arg Ser Arg Lys Cys Ser Val 
        435                 440                 445             


Ala Gly Pro Ala Trp Ala Thr Cys Thr Gly Ala Leu Thr Asp Thr Arg 
    450                 455                 460                 


Glu Cys Ser Asn Leu Glu Cys Pro Ala Thr Asp Ser Lys Trp Gly Pro 
465                 470                 475                 480 


Trp Asn Ala Trp Ser Leu Cys Ser Lys Thr Cys Asp Thr Gly Trp Gln 
                485                 490                 495     


Arg Arg Phe Arg Met Cys Gln Ala Thr Gly Thr Gln Gly Tyr Pro Cys 
            500                 505                 510         


Glu Gly Thr Gly Glu Glu Val Lys Pro Cys Ser Glu Lys Arg Cys Pro 
        515                 520                 525             


Ala Phe His Glu Met Cys Arg Asp Glu Tyr Val Met Leu Met Thr Trp 
    530                 535                 540                 


Lys Lys Ala Ala Ala Gly Glu Ile Ile Tyr Asn Lys Cys Pro Pro Asn 
545                 550                 555                 560 


Ala Ser Gly Ser Ala Ser Arg Arg Cys Leu Leu Ser Ala Gln Gly Val 
                565                 570                 575     


Ala Tyr Trp Gly Leu Pro Ser Phe Ala Arg Cys Ile Ser His Glu Tyr 
            580                 585                 590         


Arg Tyr Leu Tyr Leu Ser Leu Arg Glu His Leu Ala Lys Gly Gln Arg 
        595                 600                 605             


Met Leu Ala Gly Glu Gly Met Ser Gln Val Val Arg Ser Leu Gln Glu 
    610                 615                 620                 


Leu Leu Ala Arg Arg Thr Tyr Tyr Ser Gly Asp Leu Leu Phe Ser Val 
625                 630                 635                 640 


Asp Ile Leu Arg Asn Val Thr Asp Thr Phe Lys Arg Ala Thr Tyr Val 
                645                 650                 655     


Pro Ser Ala Asp Asp Val Gln Arg Phe Phe Gln Val Val Ser Phe Met 
            660                 665                 670         


Val Asp Ala Glu Asn Lys Glu Lys Trp Asp Asp Ala Gln Gln Val Ser 
        675                 680                 685             


Pro Gly Ser Val His Leu Leu Arg Val Val Glu Asp Phe Ile His Leu 
    690                 695                 700                 


Val Gly Asp Ala Leu Lys Ala Phe Gln Ser Ser Leu Ile Val Thr Asp 
705                 710                 715                 720 


Asn Leu Val Ile Ser Ile Gln Arg Glu Pro Val Ser Ala Val Ser Ser 
                725                 730                 735     


Asp Ile Thr Phe Pro Met Arg Gly Arg Arg Gly Met Lys Asp Trp Val 
            740                 745                 750         


Arg His Ser Glu Asp Arg Leu Phe Leu Pro Lys Glu Val Leu Ser Leu 
        755                 760                 765             


Ser Ser Pro Gly Lys Pro Ala Thr Ser Gly Ala Ala Gly Ser Pro Gly 
    770                 775                 780                 


Arg Gly Arg Gly Pro Gly Thr Val Pro Pro Gly Pro Gly His Ser His 
785                 790                 795                 800 


Gln Arg Leu Leu Pro Ala Asp Pro Asp Glu Ser Ser Tyr Phe Val Ile 
                805                 810                 815     


Gly Ala Val Leu Tyr Arg Thr Leu Gly Leu Ile Leu Pro Pro Pro Arg 
            820                 825                 830         


Pro Pro Leu Ala Val Thr Ser Arg Val Met Thr Val Thr Val Arg Pro 
        835                 840                 845             


Pro Thr Gln Pro Pro Ala Glu Pro Leu Ile Thr Val Glu Leu Ser Tyr 
    850                 855                 860                 


Ile Ile Asn Gly Thr Thr Asp Pro His Cys Ala Ser Trp Asp Tyr Ser 
865                 870                 875                 880 


Arg Ala Asp Ala Ser Ser Gly Asp Trp Asp Thr Glu Asn Cys Gln Thr 
                885                 890                 895     


Leu Glu Thr Gln Ala Ala His Thr Arg Cys Gln Cys Gln His Leu Ser 
            900                 905                 910         


Thr Phe Ala Val Leu Ala Gln Pro Pro Lys Asp Leu Thr Leu Glu Leu 
        915                 920                 925             


Ala Gly Ser Pro Ser Val Pro Leu Val Ile Gly Cys Ala Val Ser Cys 
    930                 935                 940                 


Met Ala Leu Leu Thr Leu Leu Ala Ile Tyr Ala Ala Phe Trp Arg Phe 
945                 950                 955                 960 


Ile Lys Ser Glu Arg Ser Ile Ile Leu Leu Asn Phe Cys Leu Ser Ile 
                965                 970                 975     


Leu Ala Ser Asn Ile Leu Ile Leu Val Gly Gln Ser Arg Val Leu Ser 
            980                 985                 990         


Lys Gly Val Cys Thr Met Thr Ala  Ala Phe Leu His Phe  Phe Phe Leu 
        995                 1000                 1005             


Ser Ser  Phe Cys Trp Val Leu  Thr Glu Ala Trp Gln  Ser Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ile Gly Arg Met Arg  Thr Arg Leu Val Arg  Lys Arg Phe 
    1025                 1030                 1035             


Leu Cys  Leu Gly Trp Gly Leu  Pro Ala Leu Val Val  Ala Val Ser 
    1040                 1045                 1050             


Val Gly  Phe Thr Arg Thr Lys  Gly Tyr Gly Thr Ser  Ser Tyr Cys 
    1055                 1060                 1065             


Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr Ala Phe  Val Gly Pro 
    1070                 1075                 1080             


Ala Ala  Val Ile Val Leu Val  Asn Met Leu Ile Gly  Ile Ile Val 
    1085                 1090                 1095             


Phe Asn  Lys Leu Met Ala Arg  Asp Gly Ile Ser Asp  Lys Ser Lys 
    1100                 1105                 1110             


Lys Gln  Arg Ala Gly Ser Glu  Arg Cys Pro Trp Ala  Ser Leu Leu 
    1115                 1120                 1125             


Leu Pro  Cys Ser Ala Cys Gly  Ala Val Pro Ser Pro  Leu Leu Ser 
    1130                 1135                 1140             


Ser Ala  Ser Ala Arg Asn Ala  Met Ala Ser Leu Trp  Ser Ser Cys 
    1145                 1150                 1155             


Val Val  Leu Pro Leu Leu Ala  Leu Thr Trp Met Ser  Ala Val Leu 
    1160                 1165                 1170             


Ala Met  Thr Asp Arg Arg Ser  Val Leu Phe Gln Ala  Leu Phe Ala 
    1175                 1180                 1185             


Val Phe  Asn Ser Ala Gln Gly  Phe Val Ile Thr Ala  Val His Cys 
    1190                 1195                 1200             


Phe Leu  Arg Arg Glu Val Gln  Asp Val Val Lys Cys  Gln Met Gly 
    1205                 1210                 1215             


Val Cys  Arg Ala Asp Glu Ser  Glu Asp Ser Pro Asp  Ser Cys Lys 
    1220                 1225                 1230             


Asn Gly  Gln Leu Gln Ile Leu  Ser Asp Phe Glu Lys  Asp Val Asp 
    1235                 1240                 1245             


Leu Ala  Cys Gln Thr Val Leu  Phe Lys Glu Val Asn  Thr Cys Asn 
    1250                 1255                 1260             


Pro Ser  Thr Ile Thr Gly Thr  Leu Ser Arg Leu Ser  Leu Asp Glu 
    1265                 1270                 1275             


Asp Glu  Glu Pro Lys Ser Cys  Leu Val Gly Pro Glu  Gly Ser Leu 
    1280                 1285                 1290             


Ser Phe  Ser Pro Leu Pro Gly  Asn Ile Leu Val Pro  Met Ala Ala 
    1295                 1300                 1305             


Ser Pro  Gly Leu Gly Glu Pro  Pro Pro Pro Gln Glu  Ala Asn Pro 
    1310                 1315                 1320             


Val Tyr  Met Cys Gly Glu Gly  Gly Leu Arg Gln Leu  Asp Leu Thr 
    1325                 1330                 1335             


Trp Leu  Arg Pro Thr Glu Pro  Gly Ser Glu Gly Asp  Tyr Met Val 
    1340                 1345                 1350             


Leu Pro  Arg Arg Thr Leu Ser  Leu Gln Pro Gly Gly  Gly Gly Gly 
    1355                 1360                 1365             


Gly Gly  Glu Asp Ala Pro Arg  Ala Arg Pro Glu Gly  Thr Pro Arg 
    1370                 1375                 1380             


Arg Ala  Ala Lys Thr Val Ala  His Thr Glu Gly Tyr  Pro Ser Phe 
    1385                 1390                 1395             


Leu Ser  Val Asp His Ser Gly  Leu Gly Leu Gly Pro  Ala Tyr Gly 
    1400                 1405                 1410             


Ser Leu  Gln Asn Pro Tyr Gly  Met Thr Phe Gln Pro  Pro Pro Pro 
    1415                 1420                 1425             


Thr Pro  Ser Ala Arg Gln Val  Pro Glu Pro Gly Glu  Arg Ser Arg 
    1430                 1435                 1440             


Thr Met  Pro Arg Thr Val Pro  Gly Ser Thr Met Lys  Met Gly Ser 
    1445                 1450                 1455             


Leu Glu  Arg Lys Lys Leu Arg  Tyr Ser Asp Leu Asp  Phe Glu Val 
    1460                 1465                 1470             


Met His  Thr Arg Lys Arg His  Ser Glu Leu Tyr His  Glu Leu Asn 
    1475                 1480                 1485             


Gln Lys  Phe His Thr Phe Asp  Arg Tyr Arg Ser Gln  Ser Thr Ala 
    1490                 1495                 1500             


Lys Arg  Glu Lys Arg Trp Ser  Val Ser Ser Gly Gly  Ala Ala Glu 
    1505                 1510                 1515             


Arg Ser  Val Cys Thr Asp Lys  Pro Ser Pro Gly Glu  Arg Pro Ser 
    1520                 1525                 1530             


Leu Ser  Gln His Arg Arg His  Gln Ser Trp Ser Thr  Phe Lys Ser 
    1535                 1540                 1545             


Met Thr  Leu Gly Ser Leu Pro  Pro Lys Pro Arg Glu  Arg Leu Thr 
    1550                 1555                 1560             


Leu His  Arg Ala Ala Ala Trp  Glu Pro Thr Glu Pro  Pro Asp Gly 
    1565                 1570                 1575             


Asp Phe  Gln Thr Glu Val 
    1580                 


<210>  260
<211>  1522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRB3__Homo_sapiens__NP_001695

<400>  260

Met Lys Ala Val Arg Asn Leu Leu Ile Tyr Ile Phe Ser Thr Tyr Leu 
1               5                   10                  15      


Leu Val Met Phe Gly Phe Asn Ala Ala Gln Asp Phe Trp Cys Ser Thr 
            20                  25                  30          


Leu Val Lys Gly Val Ile Tyr Gly Ser Tyr Ser Val Ser Glu Met Phe 
        35                  40                  45              


Pro Lys Asn Phe Thr Asn Cys Thr Trp Thr Leu Glu Asn Pro Asp Pro 
    50                  55                  60                  


Thr Lys Tyr Ser Ile Tyr Leu Lys Phe Ser Lys Lys Asp Leu Ser Cys 
65                  70                  75                  80  


Ser Asn Phe Ser Leu Leu Ala Tyr Gln Phe Asp His Phe Ser His Glu 
                85                  90                  95      


Lys Ile Lys Asp Leu Leu Arg Lys Asn His Ser Ile Met Gln Leu Cys 
            100                 105                 110         


Asn Ser Lys Asn Ala Phe Val Phe Leu Gln Tyr Asp Lys Asn Phe Ile 
        115                 120                 125             


Gln Ile Arg Arg Val Phe Pro Thr Asn Phe Pro Gly Leu Gln Lys Lys 
    130                 135                 140                 


Gly Glu Glu Asp Gln Lys Ser Phe Phe Glu Phe Leu Val Leu Asn Lys 
145                 150                 155                 160 


Val Ser Pro Ser Gln Phe Gly Cys His Val Leu Cys Thr Trp Leu Glu 
                165                 170                 175     


Ser Cys Leu Lys Ser Glu Asn Gly Arg Thr Glu Ser Cys Gly Ile Met 
            180                 185                 190         


Tyr Thr Lys Cys Thr Cys Pro Gln His Leu Gly Glu Trp Gly Ile Asp 
        195                 200                 205             


Asp Gln Ser Leu Ile Leu Leu Asn Asn Val Val Leu Pro Leu Asn Glu 
    210                 215                 220                 


Gln Thr Glu Gly Cys Leu Thr Gln Glu Leu Gln Thr Thr Gln Val Cys 
225                 230                 235                 240 


Asn Leu Thr Arg Glu Ala Lys Arg Pro Pro Lys Glu Glu Phe Gly Met 
                245                 250                 255     


Met Gly Asp His Thr Ile Lys Ser Gln Arg Pro Arg Ser Val His Glu 
            260                 265                 270         


Lys Arg Val Pro Gln Glu Gln Ala Asp Ala Ala Lys Phe Met Ala Gln 
        275                 280                 285             


Thr Gly Glu Ser Gly Val Glu Glu Trp Ser Gln Trp Ser Thr Cys Ser 
    290                 295                 300                 


Val Thr Cys Gly Gln Gly Ser Gln Val Arg Thr Arg Thr Cys Val Ser 
305                 310                 315                 320 


Pro Tyr Gly Thr His Cys Ser Gly Pro Leu Arg Glu Ser Arg Val Cys 
                325                 330                 335     


Asn Asn Thr Ala Leu Cys Pro Val His Gly Val Trp Glu Glu Trp Ser 
            340                 345                 350         


Pro Trp Ser Leu Cys Ser Phe Thr Cys Gly Arg Gly Gln Arg Thr Arg 
        355                 360                 365             


Thr Arg Ser Cys Thr Pro Pro Gln Tyr Gly Gly Arg Pro Cys Glu Gly 
    370                 375                 380                 


Pro Glu Thr His His Lys Pro Cys Asn Ile Ala Leu Cys Pro Val Asp 
385                 390                 395                 400 


Gly Gln Trp Gln Glu Trp Ser Ser Trp Ser Gln Cys Ser Val Thr Cys 
                405                 410                 415     


Ser Asn Gly Thr Gln Gln Arg Ser Arg Gln Cys Thr Ala Ala Ala His 
            420                 425                 430         


Gly Gly Ser Glu Cys Arg Gly Pro Trp Ala Glu Ser Arg Glu Cys Tyr 
        435                 440                 445             


Asn Pro Glu Cys Thr Ala Asn Gly Gln Trp Asn Gln Trp Gly His Trp 
    450                 455                 460                 


Ser Gly Cys Ser Lys Ser Cys Asp Gly Gly Trp Glu Arg Arg Ile Arg 
465                 470                 475                 480 


Thr Cys Gln Gly Ala Val Ile Thr Gly Gln Gln Cys Glu Gly Thr Gly 
                485                 490                 495     


Glu Glu Val Arg Arg Cys Ser Glu Gln Arg Cys Pro Ala Pro Tyr Glu 
            500                 505                 510         


Ile Cys Pro Glu Asp Tyr Leu Met Ser Met Val Trp Lys Arg Thr Pro 
        515                 520                 525             


Ala Gly Asp Leu Ala Phe Asn Gln Cys Pro Leu Asn Ala Thr Gly Thr 
    530                 535                 540                 


Thr Ser Arg Arg Cys Ser Leu Ser Leu His Gly Val Ala Phe Trp Glu 
545                 550                 555                 560 


Gln Pro Ser Phe Ala Arg Cys Ile Ser Asn Glu Tyr Arg His Leu Gln 
                565                 570                 575     


His Ser Ile Lys Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly 
            580                 585                 590         


Asp Gly Met Ser Gln Val Thr Lys Thr Leu Leu Asp Leu Thr Gln Arg 
        595                 600                 605             


Lys Asn Phe Tyr Ala Gly Asp Leu Leu Met Ser Val Glu Ile Leu Arg 
    610                 615                 620                 


Asn Val Thr Asp Thr Phe Lys Arg Ala Ser Tyr Ile Pro Ala Ser Asp 
625                 630                 635                 640 


Gly Val Gln Asn Phe Phe Gln Ile Val Ser Asn Leu Leu Asp Glu Glu 
                645                 650                 655     


Asn Lys Glu Lys Trp Glu Asp Ala Gln Gln Ile Tyr Pro Gly Ser Ile 
            660                 665                 670         


Glu Leu Met Gln Val Ile Glu Asp Phe Ile His Ile Val Gly Met Gly 
        675                 680                 685             


Met Met Asp Phe Gln Asn Ser Tyr Leu Met Thr Gly Asn Val Val Ala 
    690                 695                 700                 


Ser Ile Gln Lys Leu Pro Ala Ala Ser Val Leu Thr Asp Ile Asn Phe 
705                 710                 715                 720 


Pro Met Lys Gly Arg Lys Gly Met Val Asp Trp Ala Arg Asn Ser Glu 
                725                 730                 735     


Asp Arg Val Val Ile Pro Lys Ser Ile Phe Thr Pro Val Ser Ser Lys 
            740                 745                 750         


Glu Leu Asp Glu Ser Ser Val Phe Val Leu Gly Ala Val Leu Tyr Lys 
        755                 760                 765             


Asn Leu Asp Leu Ile Leu Pro Thr Leu Arg Asn Tyr Thr Val Ile Asn 
    770                 775                 780                 


Ser Lys Ile Ile Val Val Thr Ile Arg Pro Glu Pro Lys Thr Thr Asp 
785                 790                 795                 800 


Ser Phe Leu Glu Ile Glu Leu Ala His Leu Ala Asn Gly Thr Leu Asn 
                805                 810                 815     


Pro Tyr Cys Val Leu Trp Asp Asp Ser Lys Thr Asn Glu Ser Leu Gly 
            820                 825                 830         


Thr Trp Ser Thr Gln Gly Cys Lys Thr Val Leu Thr Asp Ala Ser His 
        835                 840                 845             


Thr Lys Cys Leu Cys Asp Arg Leu Ser Thr Phe Ala Ile Leu Ala Gln 
    850                 855                 860                 


Gln Pro Arg Glu Ile Ile Met Glu Ser Ser Gly Thr Pro Ser Val Thr 
865                 870                 875                 880 


Leu Ile Val Gly Ser Gly Leu Ser Cys Leu Ala Leu Ile Thr Leu Ala 
                885                 890                 895     


Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile 
            900                 905                 910         


Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile 
        915                 920                 925             


Leu Val Gly Gln Thr Gln Thr His Asn Lys Ser Ile Cys Thr Thr Thr 
    930                 935                 940                 


Thr Ala Phe Leu His Phe Phe Phe Leu Ala Ser Phe Cys Trp Val Leu 
945                 950                 955                 960 


Thr Glu Ala Trp Gln Ser Tyr Met Ala Val Thr Gly Lys Ile Arg Thr 
                965                 970                 975     


Arg Leu Ile Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly Leu Pro Ala 
            980                 985                 990         


Leu Val Val Ala Thr Ser Val Gly  Phe Thr Arg Thr Lys  Gly Tyr Gly 
        995                 1000                 1005             


Thr Asp  His Tyr Cys Trp Leu  Ser Leu Glu Gly Gly  Leu Leu Tyr 
    1010                 1015                 1020             


Ala Phe  Val Gly Pro Ala Ala  Ala Val Val Leu Val  Asn Met Val 
    1025                 1030                 1035             


Ile Gly  Ile Leu Val Phe Asn  Lys Leu Val Ser Arg  Asp Gly Ile 
    1040                 1045                 1050             


Leu Asp  Lys Lys Leu Lys His  Arg Ala Gly Gln Met  Ser Glu Pro 
    1055                 1060                 1065             


His Ser  Gly Leu Thr Leu Lys  Cys Ala Lys Cys Gly  Val Val Ser 
    1070                 1075                 1080             


Thr Thr  Ala Leu Ser Ala Thr  Thr Ala Ser Asn Ala  Met Ala Ser 
    1085                 1090                 1095             


Leu Trp  Ser Ser Cys Val Val  Leu Pro Leu Leu Ala  Leu Thr Trp 
    1100                 1105                 1110             


Met Ser  Ala Val Leu Ala Met  Thr Asp Lys Arg Ser  Ile Leu Phe 
    1115                 1120                 1125             


Gln Ile  Leu Phe Ala Val Phe  Asp Ser Leu Gln Gly  Phe Val Ile 
    1130                 1135                 1140             


Val Met  Val His Cys Ile Leu  Arg Arg Glu Val Gln  Asp Ala Phe 
    1145                 1150                 1155             


Arg Cys  Arg Leu Arg Asn Cys  Gln Asp Pro Ile Asn  Ala Asp Ser 
    1160                 1165                 1170             


Ser Ser  Ser Phe Pro Asn Gly  His Ala Gln Ile Met  Thr Asp Phe 
    1175                 1180                 1185             


Glu Lys  Asp Val Asp Ile Ala  Cys Arg Ser Val Leu  His Lys Asp 
    1190                 1195                 1200             


Ile Gly  Pro Cys Arg Ala Ala  Thr Ile Thr Gly Thr  Leu Ser Arg 
    1205                 1210                 1215             


Ile Ser  Leu Asn Asp Asp Glu  Glu Glu Lys Gly Thr  Asn Pro Glu 
    1220                 1225                 1230             


Gly Leu  Ser Tyr Ser Thr Leu  Pro Gly Asn Val Ile  Ser Lys Val 
    1235                 1240                 1245             


Ile Ile  Gln Gln Pro Thr Gly  Leu His Met Pro Met  Ser Met Asn 
    1250                 1255                 1260             


Glu Leu  Ser Asn Pro Cys Leu  Lys Lys Glu Asn Ser  Glu Leu Arg 
    1265                 1270                 1275             


Arg Thr  Val Tyr Leu Cys Thr  Asp Asp Asn Leu Arg  Gly Ala Asp 
    1280                 1285                 1290             


Met Asp  Ile Val His Pro Gln  Glu Arg Met Met Glu  Ser Asp Tyr 
    1295                 1300                 1305             


Ile Val  Met Pro Arg Ser Ser  Val Asn Asn Gln Pro  Ser Met Lys 
    1310                 1315                 1320             


Glu Glu  Ser Lys Met Asn Ile  Gly Met Glu Thr Leu  Pro His Glu 
    1325                 1330                 1335             


Arg Leu  Leu His Tyr Lys Val  Asn Pro Glu Phe Asn  Met Asn Pro 
    1340                 1345                 1350             


Pro Val  Met Asp Gln Phe Asn  Met Asn Leu Glu Gln  His Leu Ala 
    1355                 1360                 1365             


Pro Gln  Glu His Met Gln Asn  Leu Pro Phe Glu Pro  Arg Thr Ala 
    1370                 1375                 1380             


Val Lys  Asn Phe Met Ala Ser  Glu Leu Asp Asp Asn  Ala Gly Leu 
    1385                 1390                 1395             


Ser Arg  Ser Glu Thr Gly Ser  Thr Ile Ser Met Ser  Ser Leu Glu 
    1400                 1405                 1410             


Arg Arg  Lys Ser Arg Tyr Ser  Asp Leu Asp Phe Glu  Lys Val Met 
    1415                 1420                 1425             


His Thr  Arg Lys Arg His Met  Glu Leu Phe Gln Glu  Leu Asn Gln 
    1430                 1435                 1440             


Lys Phe  Gln Thr Leu Asp Arg  Phe Arg Asp Ile Pro  Asn Thr Ser 
    1445                 1450                 1455             


Ser Met  Glu Asn Pro Ala Pro  Asn Lys Asn Pro Trp  Asp Thr Phe 
    1460                 1465                 1470             


Lys Asn  Pro Ser Glu Tyr Pro  His Tyr Thr Thr Ile  Asn Val Leu 
    1475                 1480                 1485             


Asp Thr  Glu Ala Lys Asp Ala  Leu Glu Leu Arg Pro  Ala Glu Trp 
    1490                 1495                 1500             


Glu Lys  Cys Leu Asn Leu Pro  Leu Asp Val Gln Glu  Gly Asp Phe 
    1505                 1510                 1515             


Gln Thr  Glu Val 
    1520         


<210>  261
<211>  874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRD1__Homo_sapiens__NP_942122

<400>  261

Met Glu Lys Leu Leu Arg Leu Cys Cys Trp Tyr Ser Trp Leu Leu Leu 
1               5                   10                  15      


Phe Tyr Tyr Asn Phe Gln Val Arg Gly Val Tyr Ser Arg Ser Gln Asp 
            20                  25                  30          


His Pro Gly Phe Gln Val Leu Ala Ser Ala Ser His Tyr Trp Pro Leu 
        35                  40                  45              


Glu Asn Val Asp Gly Ile His Glu Leu Gln Asp Thr Thr Gly Asp Ile 
    50                  55                  60                  


Val Glu Gly Lys Val Asn Lys Gly Ile Tyr Leu Lys Glu Glu Lys Gly 
65                  70                  75                  80  


Val Thr Leu Leu Tyr Tyr Gly Arg Tyr Asn Ser Ser Cys Ile Ser Lys 
                85                  90                  95      


Pro Glu Gln Cys Gly Pro Glu Gly Val Thr Phe Ser Phe Phe Trp Lys 
            100                 105                 110         


Thr Gln Gly Glu Gln Ser Arg Pro Ile Pro Ser Ala Tyr Gly Gly Gln 
        115                 120                 125             


Val Ile Ser Asn Gly Phe Lys Val Cys Ser Ser Gly Gly Arg Gly Ser 
    130                 135                 140                 


Val Glu Leu Tyr Thr Arg Asp Asn Ser Met Thr Trp Glu Ala Ser Phe 
145                 150                 155                 160 


Ser Pro Pro Gly Pro Tyr Trp Thr His Val Leu Phe Thr Trp Lys Ser 
                165                 170                 175     


Lys Glu Gly Leu Lys Val Tyr Val Asn Gly Thr Leu Ser Thr Ser Asp 
            180                 185                 190         


Pro Ser Gly Lys Val Ser Arg Asp Tyr Gly Glu Ser Asn Val Asn Leu 
        195                 200                 205             


Val Ile Gly Ser Glu Gln Asp Gln Ala Lys Cys Tyr Glu Asn Gly Ala 
    210                 215                 220                 


Phe Asp Glu Phe Ile Ile Trp Glu Arg Ala Leu Thr Pro Asp Glu Ile 
225                 230                 235                 240 


Ala Met Tyr Phe Thr Ala Ala Ile Gly Lys His Ala Leu Leu Ser Ser 
                245                 250                 255     


Thr Leu Pro Ser Leu Phe Met Thr Ser Thr Ala Ser Pro Val Met Pro 
            260                 265                 270         


Thr Asp Ala Tyr His Pro Ile Ile Thr Asn Leu Thr Glu Glu Arg Lys 
        275                 280                 285             


Thr Phe Gln Ser Pro Gly Val Ile Leu Ser Tyr Leu Gln Asn Val Ser 
    290                 295                 300                 


Leu Ser Leu Pro Ser Lys Ser Leu Ser Glu Gln Thr Ala Leu Asn Leu 
305                 310                 315                 320 


Thr Lys Thr Phe Leu Lys Ala Val Gly Glu Ile Leu Leu Leu Pro Gly 
                325                 330                 335     


Trp Ile Ala Leu Ser Glu Asp Ser Ala Val Val Leu Ser Leu Ile Asp 
            340                 345                 350         


Thr Ile Asp Thr Val Met Gly His Val Ser Ser Asn Leu His Gly Ser 
        355                 360                 365             


Thr Pro Gln Val Thr Val Glu Gly Ser Ser Ala Met Ala Glu Phe Ser 
    370                 375                 380                 


Val Ala Lys Ile Leu Pro Lys Thr Val Asn Ser Ser His Tyr Arg Phe 
385                 390                 395                 400 


Pro Ala His Gly Gln Ser Phe Ile Gln Ile Pro His Glu Ala Phe His 
                405                 410                 415     


Arg His Ala Trp Ser Thr Val Val Gly Leu Leu Tyr His Ser Met His 
            420                 425                 430         


Tyr Tyr Leu Asn Asn Ile Trp Pro Ala His Thr Lys Ile Ala Glu Ala 
        435                 440                 445             


Met His His Gln Asp Cys Leu Leu Phe Ala Thr Ser His Leu Ile Ser 
    450                 455                 460                 


Leu Glu Val Ser Pro Pro Pro Thr Leu Ser Gln Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Pro Leu Ile Thr Val His Leu Lys His Arg Leu Thr Arg Lys Gln His 
                485                 490                 495     


Ser Glu Ala Thr Asn Ser Ser Asn Arg Val Phe Val Tyr Cys Ala Phe 
            500                 505                 510         


Leu Asp Phe Ser Ser Gly Glu Gly Val Trp Ser Asn His Gly Cys Ala 
        515                 520                 525             


Leu Thr Arg Gly Asn Leu Thr Tyr Ser Val Cys Arg Cys Thr His Leu 
    530                 535                 540                 


Thr Asn Phe Ala Ile Leu Met Gln Val Val Pro Leu Glu Leu Ala Arg 
545                 550                 555                 560 


Gly His Gln Val Ala Leu Ser Ser Ile Ser Tyr Val Gly Cys Ser Leu 
                565                 570                 575     


Ser Val Leu Cys Leu Val Ala Thr Leu Val Thr Phe Ala Val Leu Ser 
            580                 585                 590         


Ser Val Ser Thr Ile Arg Asn Gln Arg Tyr His Ile His Ala Asn Leu 
        595                 600                 605             


Ser Phe Ala Val Leu Val Ala Gln Val Leu Leu Leu Ile Ser Phe Arg 
    610                 615                 620                 


Leu Glu Pro Gly Thr Thr Pro Cys Gln Val Met Ala Val Leu Leu His 
625                 630                 635                 640 


Tyr Phe Phe Leu Ser Ala Phe Ala Trp Met Leu Val Glu Gly Leu His 
                645                 650                 655     


Leu Tyr Ser Met Val Ile Lys Val Phe Gly Ser Glu Asp Ser Lys His 
            660                 665                 670         


Arg Tyr Tyr Tyr Gly Met Gly Trp Gly Phe Pro Leu Leu Ile Cys Ile 
        675                 680                 685             


Ile Ser Leu Ser Phe Ala Met Asp Ser Tyr Gly Thr Ser Asn Asn Cys 
    690                 695                 700                 


Trp Leu Ser Leu Ala Ser Gly Ala Ile Trp Ala Phe Val Ala Pro Ala 
705                 710                 715                 720 


Leu Phe Val Ile Val Val Asn Ile Gly Ile Leu Ile Ala Val Thr Arg 
                725                 730                 735     


Val Ile Ser Gln Ile Ser Ala Asp Asn Tyr Lys Ile His Gly Asp Pro 
            740                 745                 750         


Ser Ala Phe Lys Leu Thr Ala Lys Ala Val Ala Val Leu Leu Pro Ile 
        755                 760                 765             


Leu Gly Thr Ser Trp Val Phe Gly Val Leu Ala Val Asn Gly Cys Ala 
    770                 775                 780                 


Val Val Phe Gln Tyr Met Phe Ala Thr Leu Asn Ser Leu Gln Gly Leu 
785                 790                 795                 800 


Phe Ile Phe Leu Phe His Cys Leu Leu Asn Ser Glu Val Arg Ala Ala 
                805                 810                 815     


Phe Lys His Lys Thr Lys Val Trp Ser Leu Thr Ser Ser Ser Ala Arg 
            820                 825                 830         


Thr Ser Asn Ala Lys Pro Phe His Ser Asp Leu Met Asn Gly Thr Arg 
        835                 840                 845             


Pro Gly Met Ala Ser Thr Lys Leu Ser Pro Trp Asp Lys Ser Ser His 
    850                 855                 860                 


Ser Ala His Arg Val Asp Leu Ser Ala Val 
865                 870                 


<210>  262
<211>  974
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRD2__Homo_sapiens__XP_006717411

<400>  262

Met Val Thr Gly Pro Glu Glu Gly Asn Ser Glu Met Asp Ala Pro Trp 
1               5                   10                  15      


Gly Ala Gly Glu Arg Trp Leu His Gly Ala Ala Val Asp Arg Ser Gly 
            20                  25                  30          


Val Ser Leu Gly Pro Pro Pro Thr Pro Gln Val Asn Gln Gly Thr Leu 
        35                  40                  45              


Gly Pro Gln Val Ala Pro Val Ala Ala Gly Glu Val Val Lys Thr Ala 
    50                  55                  60                  


Gly Gly Val Cys Lys Phe Ser Gly Gln Arg Leu Ser Trp Trp Gln Ala 
65                  70                  75                  80  


Gln Glu Ser Cys Glu Gln Gln Phe Gly His Leu Ala Leu Gln Pro Pro 
                85                  90                  95      


Asp Gly Val Leu Ala Ser Arg Leu Arg Asp Pro Val Trp Val Gly Gln 
            100                 105                 110         


Arg Glu Ala Pro Leu Arg Arg Pro Pro Gln Arg Arg Ala Arg Thr Thr 
        115                 120                 125             


Ala Val Leu Val Phe Asp Glu Arg Thr Ala Asp Arg Ala Ala Arg Leu 
    130                 135                 140                 


Arg Ser Pro Leu Pro Glu Leu Ala Ala Leu Thr Ala Cys Thr His Val 
145                 150                 155                 160 


Gln Trp Asp Cys Ala Ser Pro Asp Pro Ala Ala Leu Phe Ser Val Ala 
                165                 170                 175     


Ala Pro Ala Leu Pro Asn Ala Leu Gln Leu Arg Ala Phe Ala Glu Pro 
            180                 185                 190         


Gly Gly Val Val Arg Ala Ala Leu Val Val Arg Gly Gln His Ala Pro 
        195                 200                 205             


Phe Leu Ala Ala Phe Arg Ala Asp Gly Arg Trp His His Val Cys Ala 
    210                 215                 220                 


Thr Trp Glu Gln Arg Gly Gly Arg Trp Ala Leu Phe Ser Asp Gly Arg 
225                 230                 235                 240 


Arg Arg Ala Gly Ala Arg Gly Leu Gly Ala Gly His Pro Val Pro Ser 
                245                 250                 255     


Gly Gly Ile Leu Val Leu Gly Gln Asp Gln Asp Ser Leu Gly Gly Gly 
            260                 265                 270         


Phe Ser Val Arg His Ala Leu Ser Gly Asn Leu Thr Asp Phe His Leu 
        275                 280                 285             


Trp Ala Arg Ala Leu Ser Pro Ala Gln Leu His Arg Ala Arg Ala Cys 
    290                 295                 300                 


Ala Pro Pro Ser Glu Gly Leu Leu Phe Arg Trp Asp Pro Gly Ala Leu 
305                 310                 315                 320 


Asp Val Thr Pro Ser Leu Leu Pro Thr Val Trp Val Arg Leu Leu Cys 
                325                 330                 335     


Pro Val Pro Ser Glu Glu Cys Pro Thr Trp Asn Pro Gly Pro Arg Ser 
            340                 345                 350         


Glu Gly Ser Glu Leu Cys Leu Glu Pro Gln Pro Phe Leu Cys Cys Tyr 
        355                 360                 365             


Arg Thr Glu Pro Tyr Arg Arg Leu Gln Asp Ala Gln Ser Trp Pro Gly 
    370                 375                 380                 


Gln Asp Val Ile Ser Arg Val Asn Ala Leu Ala Asn Asp Ile Val Leu 
385                 390                 395                 400 


Leu Pro Asp Pro Leu Ser Glu Val His Gly Ala Leu Ser Pro Ala Glu 
                405                 410                 415     


Ala Ser Ser Phe Leu Gly Leu Leu Glu His Val Leu Ala Met Glu Met 
            420                 425                 430         


Ala Pro Leu Gly Pro Ala Ala Leu Leu Ala Val Val Arg Phe Leu Lys 
        435                 440                 445             


Arg Val Val Ala Leu Gly Ala Gly Asp Pro Glu Leu Leu Leu Thr Gly 
    450                 455                 460                 


Pro Trp Glu Gln Leu Ser Gln Gly Val Val Ser Val Ala Ser Leu Val 
465                 470                 475                 480 


Leu Glu Glu Gln Val Ala Asp Thr Trp Leu Ser Leu Arg Glu Val Ile 
                485                 490                 495     


Gly Gly Pro Met Ala Leu Val Ala Ser Val Gln Arg Leu Ala Pro Leu 
            500                 505                 510         


Leu Ser Thr Ser Met Thr Ser Glu Arg Pro Arg Met Arg Ile Gln His 
        515                 520                 525             


Arg His Ala Gly Leu Ser Gly Val Thr Val Ile His Ser Trp Phe Thr 
    530                 535                 540                 


Ser Arg Val Phe Gln His Thr Leu Glu Gly Pro Asp Leu Glu Pro Gln 
545                 550                 555                 560 


Ala Pro Ala Ser Ser Glu Glu Ala Asn Arg Val Gln Arg Phe Leu Ser 
                565                 570                 575     


Thr Gln Val Gly Ser Ala Ile Ile Ser Ser Glu Val Trp Asp Val Thr 
            580                 585                 590         


Gly Glu Val Asn Val Ala Met Thr Phe His Leu Gln His Arg Ala Gln 
        595                 600                 605             


Ser Pro Leu Phe Pro Pro His Pro Pro Ser Pro Tyr Thr Gly Gly Ala 
    610                 615                 620                 


Trp Ala Thr Thr Gly Cys Ser Val Ala Ala Leu Tyr Leu Asp Ser Thr 
625                 630                 635                 640 


Ala Cys Phe Cys Asn His Ser Thr Ser Phe Ala Ile Leu Leu Gln Ile 
                645                 650                 655     


Tyr Glu Val Gln Arg Gly Pro Glu Glu Glu Ser Leu Leu Arg Thr Leu 
            660                 665                 670         


Ser Phe Val Gly Cys Gly Val Ser Phe Cys Ala Leu Thr Thr Thr Phe 
        675                 680                 685             


Leu Leu Phe Leu Val Ala Gly Val Pro Lys Ser Glu Arg Thr Thr Val 
    690                 695                 700                 


His Lys Asn Leu Thr Phe Ser Leu Ala Ser Ala Glu Gly Phe Leu Met 
705                 710                 715                 720 


Thr Ser Glu Trp Ala Lys Ala Asn Glu Val Ala Cys Val Ala Val Thr 
                725                 730                 735     


Val Ala Met His Phe Leu Phe Leu Val Ala Phe Ser Trp Met Leu Val 
            740                 745                 750         


Glu Gly Leu Leu Leu Trp Arg Lys Val Val Ala Val Ser Met His Pro 
        755                 760                 765             


Gly Pro Gly Met Arg Leu Tyr His Ala Thr Gly Trp Gly Val Pro Val 
    770                 775                 780                 


Gly Ile Val Ala Val Thr Leu Ala Met Leu Pro His Asp Tyr Val Ala 
785                 790                 795                 800 


Pro Gly His Cys Trp Leu Asn Val His Thr Asn Ala Ile Trp Ala Phe 
                805                 810                 815     


Val Gly Pro Val Leu Phe Val Leu Thr Ala Asn Thr Cys Ile Leu Ala 
            820                 825                 830         


Arg Val Val Met Ile Thr Val Ser Ser Ala Arg Arg Arg Ala Arg Met 
        835                 840                 845             


Leu Ser Pro Gln Pro Cys Leu Gln Gln Gln Ile Trp Thr Gln Ile Trp 
    850                 855                 860                 


Ala Thr Val Lys Pro Val Leu Val Leu Leu Pro Val Leu Gly Leu Thr 
865                 870                 875                 880 


Trp Leu Ala Gly Ile Leu Val His Leu Ser Pro Ala Trp Ala Tyr Ala 
                885                 890                 895     


Ala Val Gly Leu Asn Ser Ile Gln Gly Leu Tyr Ile Phe Leu Val Tyr 
            900                 905                 910         


Ala Ala Cys Asn Glu Glu Val Arg Ser Ala Leu Gln Arg Met Ala Glu 
        915                 920                 925             


Lys Lys Val Ala Glu Val Leu Arg Ala Leu Gly Val Trp Gly Gly Ala 
    930                 935                 940                 


Ala Lys Glu His Ser Leu Pro Phe Ser Val Leu Pro Leu Phe Leu Pro 
945                 950                 955                 960 


Pro Lys Pro Ser Thr Pro Arg His Pro Leu Lys Ala Pro Ala 
                965                 970                 


<210>  263
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRE1__Homo_sapiens__NP_001243181

<400>  263

Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Thr Arg Lys Pro Asn Thr Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Thr Leu Cys Pro Ala Tyr Ala Thr Cys Thr 
        35                  40                  45              


Asn Thr Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asn Glu Cys Leu Thr Ser Ser Val Cys Pro Glu His Ser Asp Cys 
                85                  90                  95      


Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln Val Gly Phe Ile 
            100                 105                 110         


Ser Arg Asn Ser Thr Cys Glu Asp Val Asp Glu Cys Ala Asp Pro Arg 
        115                 120                 125             


Ala Cys Pro Glu His Ala Thr Cys Asn Asn Thr Val Gly Asn Tyr Ser 
    130                 135                 140                 


Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly His Leu Ser Phe 
145                 150                 155                 160 


Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu Cys Thr Glu Met 
                165                 170                 175     


Cys Pro Ile Asn Ser Thr Cys Thr Asn Thr Pro Gly Ser Tyr Phe Cys 
            180                 185                 190         


Thr Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln Leu Asn Phe Thr 
        195                 200                 205             


Asp Gln Gly Val Glu Cys Arg Asp Ile Asp Glu Cys Arg Gln Asp Pro 
    210                 215                 220                 


Ser Thr Cys Gly Pro Asn Ser Ile Cys Thr Asn Ala Leu Gly Ser Tyr 
225                 230                 235                 240 


Ser Cys Gly Cys Ile Ala Gly Phe His Pro Asn Pro Glu Gly Ser Gln 
                245                 250                 255     


Lys Asp Gly Asn Phe Ser Cys Gln Arg Val Leu Phe Lys Cys Lys Glu 
            260                 265                 270         


Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys Gln Glu Gly Thr 
        275                 280                 285             


Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln Ile Asn Asn Ile 
    290                 295                 300                 


Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Thr Thr Val Val Ser 
305                 310                 315                 320 


Leu Lys Asn Thr Thr Glu Ser Phe Val Pro Val Leu Lys Gln Ile Ser 
                325                 330                 335     


Thr Trp Thr Lys Phe Thr Lys Glu Glu Thr Ser Ser Leu Ala Thr Val 
            340                 345                 350         


Phe Leu Glu Ser Val Glu Ser Met Thr Leu Ala Ser Phe Trp Lys Pro 
        355                 360                 365             


Ser Ala Asn Ile Thr Pro Ala Val Arg Thr Glu Tyr Leu Asp Ile Glu 
    370                 375                 380                 


Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn Val Thr Leu Asp 
385                 390                 395                 400 


Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys Ser Thr Ile Glu 
                405                 410                 415     


Glu Ser Glu Ser Thr Glu Thr Thr Gly Val Ala Phe Val Ser Phe Val 
            420                 425                 430         


Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys Asp His Gln Ala 
        435                 440                 445             


Pro Leu Thr Thr Ser Glu Ile Lys Leu Lys Met Asn Ser Arg Val Val 
    450                 455                 460                 


Gly Gly Ile Met Thr Gly Glu Lys Lys Asp Gly Phe Ser Asp Pro Ile 
465                 470                 475                 480 


Ile Tyr Thr Leu Glu Asn Ile Gln Pro Lys Gln Lys Phe Glu Arg Pro 
                485                 490                 495     


Ile Cys Val Ser Trp Ser Thr Asp Val Lys Gly Gly Arg Trp Thr Ser 
            500                 505                 510         


Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Thr Tyr Thr Ile Cys Ser 
        515                 520                 525             


Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala Ser Gly Glu Leu 
    530                 535                 540                 


Thr Met Asp Phe Ser Leu Tyr Ile Ile Ser His Val Gly Ile Ile Ile 
545                 550                 555                 560 


Ser Leu Val Cys Leu Val Leu Ala Ile Ala Thr Phe Leu Leu Cys Arg 
                565                 570                 575     


Ser Ile Arg Asn His Asn Thr Tyr Leu His Leu His Leu Cys Val Cys 
            580                 585                 590         


Leu Leu Leu Ala Lys Thr Leu Phe Leu Ala Gly Ile His Lys Thr Asp 
        595                 600                 605             


Asn Lys Met Gly Cys Ala Ile Ile Ala Gly Phe Leu His Tyr Leu Phe 
    610                 615                 620                 


Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val Ile Leu Phe Leu 
625                 630                 635                 640 


Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser Ser Arg Asn Ile 
                645                 650                 655     


Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu Pro Met Leu Val 
            660                 665                 670         


Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr Gly Met His Asn 
        675                 680                 685             


Arg Cys Trp Leu Asn Thr Glu Thr Gly Phe Ile Trp Ser Phe Leu Gly 
    690                 695                 700                 


Pro Val Cys Thr Val Ile Val Val Ser Lys Tyr Tyr Asn Ser Leu Ala 
705                 710                 715                 720 


Lys Cys Val Leu Lys Glu Glu Gln Gly Asp Leu Arg Asp Leu Glu Phe 
                725                 730                 735     


Pro Gly Thr Cys Ala Ala Glu Arg Ile Asn Ser Leu Leu Leu Thr Trp 
            740                 745                 750         


Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn Ala Glu Val 
        755                 760                 765             


Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala Phe Ala Gln 
    770                 775                 780                 


Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe Gln Ile Gly 
785                 790                 795                 800 


Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu 
                805                 810                 815     


Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn Gly Gln Val 
            820                 825                 830         


Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr Lys Pro Ser Ser 
        835                 840                 845             


Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met Pro Ser Ala Ser 
    850                 855                 860                 


Lys Thr Gly 
865         


<210>  264
<211>  765
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRE2__Homo_sapiens__NP_001257981

<400>  264

Met Gly Gly Arg Val Phe Leu Val Phe Leu Ala Phe Cys Val Trp Leu 
1               5                   10                  15      


Thr Leu Pro Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp 
            20                  25                  30          


Cys Pro Gln Asp Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn 
        35                  40                  45              


Pro Gly Phe Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Met Glu Thr 
    50                  55                  60                  


Cys Asp Asp Ile Asn Glu Cys Ala Thr Leu Ser Lys Val Ser Cys Gly 
65                  70                  75                  80  


Lys Phe Ser Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys 
                85                  90                  95      


Ser Pro Gly Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu 
            100                 105                 110         


Ser Glu Asn Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg 
        115                 120                 125             


Leu Cys Lys Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr 
    130                 135                 140                 


Cys Gln Cys Leu Pro Gly Phe Lys Leu Lys Pro Glu Asp Pro Lys Leu 
145                 150                 155                 160 


Cys Thr Asp Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser 
                165                 170                 175     


Ser Thr His Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg 
            180                 185                 190         


Pro Gly Trp Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr 
        195                 200                 205             


Val Cys Glu Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp 
    210                 215                 220                 


Ser Ser Thr Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys 
225                 230                 235                 240 


Arg Pro Gly Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp 
                245                 250                 255     


Thr Val Cys Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly 
            260                 265                 270         


Val His Ser Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu 
        275                 280                 285             


Gly Arg Asp Tyr Lys Pro Gly Leu Ala Asn Asn Thr Ile Gln Ser Ile 
    290                 295                 300                 


Leu Gln Ala Leu Asp Glu Leu Leu Glu Ala Pro Gly Asp Leu Glu Thr 
305                 310                 315                 320 


Leu Pro Arg Leu Gln Gln His Cys Val Ala Ser His Leu Leu Asp Gly 
                325                 330                 335     


Leu Glu Asp Val Leu Arg Gly Leu Ser Lys Asn Leu Ser Asn Gly Leu 
            340                 345                 350         


Leu Asn Phe Ser Tyr Pro Ala Gly Thr Glu Leu Ser Leu Glu Val Gln 
        355                 360                 365             


Lys Gln Val Asp Arg Ser Val Thr Leu Arg Gln Asn Gln Ala Val Met 
    370                 375                 380                 


Gln Leu Asp Trp Asn Gln Ala Gln Lys Ser Gly Asp Pro Gly Pro Ser 
385                 390                 395                 400 


Val Val Gly Leu Val Ser Ile Pro Gly Met Gly Lys Leu Leu Ala Glu 
                405                 410                 415     


Ala Pro Leu Val Leu Glu Pro Glu Lys Gln Met Leu Leu His Glu Thr 
            420                 425                 430         


His Gln Gly Leu Leu Gln Asp Gly Ser Pro Ile Leu Leu Ser Asp Val 
        435                 440                 445             


Ile Ser Ala Phe Leu Ser Asn Asn Asp Thr Gln Asn Leu Ser Ser Pro 
    450                 455                 460                 


Val Thr Phe Thr Phe Ser His Arg Glu Glu Asp Pro Val Leu Thr Val 
465                 470                 475                 480 


Ile Thr Tyr Met Gly Leu Ser Val Ser Leu Leu Cys Leu Leu Leu Ala 
                485                 490                 495     


Ala Leu Thr Phe Leu Leu Cys Lys Ala Ile Gln Asn Thr Ser Thr Ser 
            500                 505                 510         


Leu His Leu Gln Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu Phe 
        515                 520                 525             


Leu Val Ala Ile Asp Gln Thr Gly His Lys Val Leu Cys Ser Ile Ile 
    530                 535                 540                 


Ala Gly Thr Leu His Tyr Leu Tyr Leu Ala Thr Leu Thr Trp Met Leu 
545                 550                 555                 560 


Leu Glu Ala Leu Tyr Leu Phe Leu Thr Ala Arg Asn Leu Thr Val Val 
                565                 570                 575     


Asn Tyr Ser Ser Ile Asn Arg Phe Met Lys Lys Leu Met Phe Pro Val 
            580                 585                 590         


Gly Tyr Gly Val Pro Ala Val Thr Val Ala Ile Ser Ala Ala Ser Arg 
        595                 600                 605             


Pro His Leu Tyr Gly Thr Pro Ser Arg Cys Trp Leu Gln Pro Glu Lys 
    610                 615                 620                 


Gly Phe Ile Trp Gly Phe Leu Gly Pro Val Cys Ala Ile Phe Ser Val 
625                 630                 635                 640 


Asn Leu Val Leu Phe Leu Val Thr Leu Trp Ile Leu Lys Asn Arg Leu 
                645                 650                 655     


Ser Ser Leu Asn Ser Glu Val Ser Thr Leu Arg Asn Thr Arg Met Leu 
            660                 665                 670         


Ala Phe Lys Ala Thr Ala Gln Leu Phe Ile Leu Gly Cys Thr Trp Cys 
        675                 680                 685             


Leu Gly Ile Leu Gln Val Gly Pro Ala Ala Arg Val Met Ala Tyr Leu 
    690                 695                 700                 


Phe Thr Ile Ile Asn Ser Leu Gln Gly Val Phe Ile Phe Leu Val Tyr 
705                 710                 715                 720 


Cys Leu Leu Ser Gln Gln Val Arg Glu Gln Tyr Gly Lys Trp Ser Lys 
                725                 730                 735     


Gly Ile Arg Lys Leu Lys Thr Glu Ser Glu Met His Thr Leu Ser Ser 
            740                 745                 750         


Ser Ala Lys Ala Asp Thr Ser Lys Pro Ser Thr Val Asn 
        755                 760                 765 


<210>  265
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRE5__Homo_sapiens__NP_001020331

<400>  265

Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 
1               5                   10                  15      


Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 
            20                  25                  30          


Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 
        35                  40                  45              


Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 
    50                  55                  60                  


Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 
65                  70                  75                  80  


Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 
                85                  90                  95      


Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 
            100                 105                 110         


Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 
        115                 120                 125             


Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 
    130                 135                 140                 


Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 
145                 150                 155                 160 


Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr Val 
                165                 170                 175     


Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly Trp 
            180                 185                 190         


Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys Glu 
        195                 200                 205             


Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser Gln 
    210                 215                 220                 


Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp Ser 
225                 230                 235                 240 


Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu Val 
                245                 250                 255     


Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro Pro 
            260                 265                 270         


Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp Ile 
        275                 280                 285             


Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr Ile 
    290                 295                 300                 


Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly Asp 
305                 310                 315                 320 


Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn Trp 
                325                 330                 335     


Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly Ile 
            340                 345                 350         


Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu Asn 
        355                 360                 365             


Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser Ser 
    370                 375                 380                 


Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile Phe 
385                 390                 395                 400 


Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe Ala 
                405                 410                 415     


Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro Pro 
            420                 425                 430         


Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala Phe 
        435                 440                 445             


Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly Cys 
    450                 455                 460                 


Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser His 
465                 470                 475                 480 


Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp Trp 
                485                 490                 495     


Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe Cys 
            500                 505                 510         


Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln Gly 
        515                 520                 525             


Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val Gly 
    530                 535                 540                 


Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val Gly 
545                 550                 555                 560 


Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu Ala 
                565                 570                 575     


Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu Val 
            580                 585                 590         


Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys Leu 
        595                 600                 605             


Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala Ile 
    610                 615                 620                 


Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe Glu 
625                 630                 635                 640 


Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile Leu 
                645                 650                 655     


Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln Lys 
            660                 665                 670         


Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg Ala 
        675                 680                 685             


Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr Trp 
    690                 695                 700                 


Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr Tyr 
705                 710                 715                 720 


Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu Leu 
                725                 730                 735     


His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp Ala 
            740                 745                 750         


Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr Thr 
        755                 760                 765             


Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu Ser 
    770                 775                 780                 


Gly Ile 
785     


<210>  266
<211>  1346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRF5__Homo_sapiens__NP_056049

<400>  266

Met Lys Ser Pro Arg Arg Thr Thr Leu Cys Leu Met Phe Ile Val Ile 
1               5                   10                  15      


Tyr Ser Ser Lys Ala Ala Leu Asn Trp Asn Tyr Glu Ser Thr Ile His 
            20                  25                  30          


Pro Leu Ser Leu His Glu His Glu Pro Ala Gly Glu Glu Ala Leu Arg 
        35                  40                  45              


Gln Lys Arg Ala Val Ala Thr Lys Ser Pro Thr Ala Glu Glu Tyr Thr 
    50                  55                  60                  


Val Asn Ile Glu Ile Ser Phe Glu Asn Ala Ser Phe Leu Asp Pro Ile 
65                  70                  75                  80  


Lys Ala Tyr Leu Asn Ser Leu Ser Phe Pro Ile His Gly Asn Asn Thr 
                85                  90                  95      


Asp Gln Ile Thr Asp Ile Leu Ser Ile Asn Val Thr Thr Val Cys Arg 
            100                 105                 110         


Pro Ala Gly Asn Glu Ile Trp Cys Ser Cys Glu Thr Gly Tyr Gly Trp 
        115                 120                 125             


Pro Arg Glu Arg Cys Leu His Asn Leu Ile Cys Gln Glu Arg Asp Val 
    130                 135                 140                 


Phe Leu Pro Gly His His Cys Ser Cys Leu Lys Glu Leu Pro Pro Asn 
145                 150                 155                 160 


Gly Pro Phe Cys Leu Leu Gln Glu Asp Val Thr Leu Asn Met Arg Val 
                165                 170                 175     


Arg Leu Asn Val Gly Phe Gln Glu Asp Leu Met Asn Thr Ser Ser Ala 
            180                 185                 190         


Leu Tyr Arg Ser Tyr Lys Thr Asp Leu Glu Thr Ala Phe Arg Lys Gly 
        195                 200                 205             


Tyr Gly Ile Leu Pro Gly Phe Lys Gly Val Thr Val Thr Gly Phe Lys 
    210                 215                 220                 


Ser Gly Ser Val Val Val Thr Tyr Glu Val Lys Thr Thr Pro Pro Ser 
225                 230                 235                 240 


Leu Glu Leu Ile His Lys Ala Asn Glu Gln Val Val Gln Ser Leu Asn 
                245                 250                 255     


Gln Thr Tyr Lys Met Asp Tyr Asn Ser Phe Gln Ala Val Thr Ile Asn 
            260                 265                 270         


Glu Ser Asn Phe Phe Val Thr Pro Glu Ile Ile Phe Glu Gly Asp Thr 
        275                 280                 285             


Val Ser Leu Val Cys Glu Lys Glu Val Leu Ser Ser Asn Val Ser Trp 
    290                 295                 300                 


Arg Tyr Glu Glu Gln Gln Leu Glu Ile Gln Asn Ser Ser Arg Phe Ser 
305                 310                 315                 320 


Ile Tyr Thr Ala Leu Phe Asn Asn Met Thr Ser Val Ser Lys Leu Thr 
                325                 330                 335     


Ile His Asn Ile Thr Pro Gly Asp Ala Gly Glu Tyr Val Cys Lys Leu 
            340                 345                 350         


Ile Leu Asp Ile Phe Glu Tyr Glu Cys Lys Lys Lys Ile Asp Val Met 
        355                 360                 365             


Pro Ile Gln Ile Leu Ala Asn Glu Glu Met Lys Val Met Cys Asp Asn 
    370                 375                 380                 


Asn Pro Val Ser Leu Asn Cys Cys Ser Gln Gly Asn Val Asn Trp Ser 
385                 390                 395                 400 


Lys Val Glu Trp Lys Gln Glu Gly Lys Ile Asn Ile Pro Gly Thr Pro 
                405                 410                 415     


Glu Thr Asp Ile Asp Ser Ser Cys Ser Arg Tyr Thr Leu Lys Ala Asp 
            420                 425                 430         


Gly Thr Gln Cys Pro Ser Gly Ser Ser Gly Thr Thr Val Ile Tyr Thr 
        435                 440                 445             


Cys Glu Phe Ile Ser Ala Tyr Gly Ala Arg Gly Ser Ala Asn Ile Lys 
    450                 455                 460                 


Val Thr Phe Ile Ser Val Ala Asn Leu Thr Ile Thr Pro Asp Pro Ile 
465                 470                 475                 480 


Ser Val Ser Glu Gly Gln Asn Phe Ser Ile Lys Cys Ile Ser Asp Val 
                485                 490                 495     


Ser Asn Tyr Asp Glu Val Tyr Trp Asn Thr Ser Ala Gly Ile Lys Ile 
            500                 505                 510         


Tyr Gln Arg Phe Tyr Thr Thr Arg Arg Tyr Leu Asp Gly Ala Glu Ser 
        515                 520                 525             


Val Leu Thr Val Lys Thr Ser Thr Arg Glu Trp Asn Gly Thr Tyr His 
    530                 535                 540                 


Cys Ile Phe Arg Tyr Lys Asn Ser Tyr Ser Ile Ala Thr Lys Asp Val 
545                 550                 555                 560 


Ile Val His Pro Leu Pro Leu Lys Leu Asn Ile Met Val Asp Pro Leu 
                565                 570                 575     


Glu Ala Thr Val Ser Cys Ser Gly Ser His His Ile Lys Cys Cys Ile 
            580                 585                 590         


Glu Glu Asp Gly Asp Tyr Lys Val Thr Phe His Thr Gly Ser Ser Ser 
        595                 600                 605             


Leu Pro Ala Ala Lys Glu Val Asn Lys Lys Gln Val Cys Tyr Lys His 
    610                 615                 620                 


Asn Phe Asn Ala Ser Ser Val Ser Trp Cys Ser Lys Thr Val Asp Val 
625                 630                 635                 640 


Cys Cys His Phe Thr Asn Ala Ala Asn Asn Ser Val Trp Ser Pro Ser 
                645                 650                 655     


Met Lys Leu Asn Leu Val Pro Gly Glu Asn Ile Thr Cys Gln Asp Pro 
            660                 665                 670         


Val Ile Gly Val Gly Glu Pro Gly Lys Val Ile Gln Lys Leu Cys Arg 
        675                 680                 685             


Phe Ser Asn Val Pro Ser Ser Pro Glu Ser Pro Ile Gly Gly Thr Ile 
    690                 695                 700                 


Thr Tyr Lys Cys Val Gly Ser Gln Trp Glu Glu Lys Arg Asn Asp Cys 
705                 710                 715                 720 


Ile Ser Ala Pro Ile Asn Ser Leu Leu Gln Met Ala Lys Ala Leu Ile 
                725                 730                 735     


Lys Ser Pro Ser Gln Asp Glu Met Leu Pro Thr Tyr Leu Lys Asp Leu 
            740                 745                 750         


Ser Ile Ser Ile Asp Lys Ala Glu His Glu Ile Ser Ser Ser Pro Gly 
        755                 760                 765             


Ser Leu Gly Ala Ile Ile Asn Ile Leu Asp Leu Leu Ser Thr Val Pro 
    770                 775                 780                 


Thr Gln Val Asn Ser Glu Met Met Thr His Val Leu Ser Thr Val Asn 
785                 790                 795                 800 


Val Ile Leu Gly Lys Pro Val Leu Asn Thr Trp Lys Val Leu Gln Gln 
                805                 810                 815     


Gln Trp Thr Asn Gln Ser Ser Gln Leu Leu His Ser Val Glu Arg Phe 
            820                 825                 830         


Ser Gln Ala Leu Gln Ser Gly Asp Ser Pro Pro Leu Ser Phe Ser Gln 
        835                 840                 845             


Thr Asn Val Gln Met Ser Ser Met Val Ile Lys Ser Ser His Pro Glu 
    850                 855                 860                 


Thr Tyr Gln Gln Arg Phe Val Phe Pro Tyr Phe Asp Leu Trp Gly Asn 
865                 870                 875                 880 


Val Val Ile Asp Lys Ser Tyr Leu Glu Asn Leu Gln Ser Asp Ser Ser 
                885                 890                 895     


Ile Val Thr Met Ala Phe Pro Thr Leu Gln Ala Ile Leu Ala Gln Asp 
            900                 905                 910         


Ile Gln Glu Asn Asn Phe Ala Glu Ser Leu Val Met Thr Thr Thr Val 
        915                 920                 925             


Ser His Asn Thr Thr Met Pro Phe Arg Ile Ser Met Thr Phe Lys Asn 
    930                 935                 940                 


Asn Ser Pro Ser Gly Gly Glu Thr Lys Cys Val Phe Trp Asn Phe Arg 
945                 950                 955                 960 


Leu Ala Asn Asn Thr Gly Gly Trp Asp Ser Ser Gly Cys Tyr Val Glu 
                965                 970                 975     


Glu Gly Asp Gly Asp Asn Val Thr Cys Ile Cys Asp His Leu Thr Ser 
            980                 985                 990         


Phe Ser Ile Leu Met Ser Pro Asp  Ser Pro Asp Pro Ser  Ser Leu Leu 
        995                 1000                 1005             


Gly Ile  Leu Leu Asp Ile Ile  Ser Tyr Val Gly Val  Gly Phe Ser 
    1010                 1015                 1020             


Ile Leu  Ser Leu Ala Ala Cys  Leu Val Val Glu Ala  Val Val Trp 
    1025                 1030                 1035             


Lys Ser  Val Thr Lys Asn Arg  Thr Ser Tyr Met Arg  His Thr Cys 
    1040                 1045                 1050             


Ile Val  Asn Ile Ala Ala Ser  Leu Leu Val Ala Asn  Thr Trp Phe 
    1055                 1060                 1065             


Ile Val  Val Ala Ala Ile Gln  Asp Asn Arg Tyr Ile  Leu Cys Lys 
    1070                 1075                 1080             


Thr Ala  Cys Val Ala Ala Thr  Phe Phe Ile His Phe  Phe Tyr Leu 
    1085                 1090                 1095             


Ser Val  Phe Phe Trp Met Leu  Thr Leu Gly Leu Met  Leu Phe Tyr 
    1100                 1105                 1110             


Arg Leu  Val Phe Ile Leu His  Glu Thr Ser Arg Ser  Thr Gln Lys 
    1115                 1120                 1125             


Ala Ile  Ala Phe Cys Leu Gly  Tyr Gly Cys Pro Leu  Ala Ile Ser 
    1130                 1135                 1140             


Val Ile  Thr Leu Gly Ala Thr  Gln Pro Arg Glu Val  Tyr Thr Arg 
    1145                 1150                 1155             


Lys Asn  Val Cys Trp Leu Asn  Trp Glu Asp Thr Lys  Ala Leu Leu 
    1160                 1165                 1170             


Ala Phe  Ala Ile Pro Ala Leu  Ile Ile Val Val Val  Asn Ile Thr 
    1175                 1180                 1185             


Ile Thr  Ile Val Val Ile Thr  Lys Ile Leu Arg Pro  Ser Ile Gly 
    1190                 1195                 1200             


Asp Lys  Pro Cys Lys Gln Glu  Lys Ser Ser Leu Phe  Gln Ile Ser 
    1205                 1210                 1215             


Lys Ser  Ile Gly Val Leu Thr  Pro Leu Leu Gly Leu  Thr Trp Gly 
    1220                 1225                 1230             


Phe Gly  Leu Thr Thr Val Phe  Pro Gly Thr Asn Leu  Val Phe His 
    1235                 1240                 1245             


Ile Ile  Phe Ala Ile Leu Asn  Val Phe Gln Gly Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Phe  Gly Cys Leu Trp Asp  Leu Lys Val Gln Glu  Ala Leu Leu 
    1265                 1270                 1275             


Asn Lys  Phe Ser Leu Ser Arg  Trp Ser Ser Gln His  Ser Lys Ser 
    1280                 1285                 1290             


Thr Ser  Leu Gly Ser Ser Thr  Pro Val Phe Ser Met  Ser Ser Pro 
    1295                 1300                 1305             


Ile Ser  Arg Arg Phe Asn Asn  Leu Phe Gly Lys Thr  Gly Thr Tyr 
    1310                 1315                 1320             


Asn Val  Ser Thr Pro Glu Ala  Thr Ser Ser Ser Leu  Glu Asn Ser 
    1325                 1330                 1335             


Ser Ser  Ala Ser Ser Leu Leu  Asn 
    1340                 1345     


<210>  267
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRG1__Homo_sapiens__NP_001277071

<400>  267

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser 
        35                  40                  45              


Val Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile Asn 
    50                  55                  60                  


Ala Thr Val Trp Lys Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu His 
65                  70                  75                  80  


Ile His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser 
                85                  90                  95      


Val Leu Leu Pro Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly 
            100                 105                 110         


Glu Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala Leu 
        115                 120                 125             


Phe Gln Asp Lys Asn Ser Ser Gln Val Leu Gly Glu Lys Val Leu Gly 
    130                 135                 140                 


Ile Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val 
145                 150                 155                 160 


Leu Thr Phe Gln His Gln Leu Gln Pro Lys Asn Val Thr Leu Gln Cys 
                165                 170                 175     


Val Phe Trp Val Glu Asp Pro Thr Leu Ser Ser Pro Gly His Trp Ser 
            180                 185                 190         


Ser Ala Gly Cys Glu Thr Val Arg Arg Glu Thr Gln Thr Ser Cys Phe 
        195                 200                 205             


Cys Asn His Leu Thr Tyr Phe Ala Val Leu Met Val Ser Ser Val Glu 
    210                 215                 220                 


Val Asp Ala Val His Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly 
225                 230                 235                 240 


Cys Val Val Ser Ala Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu 
                245                 250                 255     


Cys Ser Arg Val Pro Leu Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr 
            260                 265                 270         


Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe Leu Leu Asp Thr 
        275                 280                 285             


Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly Ser Glu Ala Gly 
    290                 295                 300                 


Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu Leu Thr Cys Leu 
305                 310                 315                 320 


Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu 
                325                 330                 335     


Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met 
            340                 345                 350         


Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val Ala Leu Val Asp 
        355                 360                 365             


Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His Arg Thr Pro Glu 
    370                 375                 380                 


Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp Ser Leu Val Ser 
385                 390                 395                 400 


Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe Leu Phe Asn Met 
                405                 410                 415     


Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg Leu Arg Pro His 
            420                 425                 430         


Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly Leu Ser Leu Val 
        435                 440                 445             


Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr 
    450                 455                 460                 


Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln 
465                 470                 475                 480 


Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg 
                485                 490                 495     


Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro 
            500                 505                 510         


Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 
        515                 520             


<210>  268
<211>  1017
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRG2__Homo_sapiens__NP_001073327

<400>  268

Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu 
1               5                   10                  15      


Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val 
            20                  25                  30          


Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser 
        35                  40                  45              


Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn 
    50                  55                  60                  


Gly Thr Pro Glu Val Glu Thr Thr Ser Leu Asn Asp Val Thr Leu Ser 
65                  70                  75                  80  


Leu Leu Pro Ser Asn Glu Thr Glu Lys Thr Lys Ile Thr Ile Val Lys 
                85                  90                  95      


Thr Phe Asn Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu 
            100                 105                 110         


Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe 
        115                 120                 125             


Gln Tyr Asp Lys Glu Ser Thr Val Pro Gln Asn Gln His Ile Thr Asn 
    130                 135                 140                 


Gly Thr Leu Thr Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu 
145                 150                 155                 160 


Leu Asn Lys Thr Leu Gln Thr Leu Ser Glu Thr Tyr Phe Ile Met Cys 
                165                 170                 175     


Ala Thr Ala Glu Ala Gln Ser Thr Leu Asn Cys Thr Phe Thr Ile Lys 
            180                 185                 190         


Leu Asn Asn Thr Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg 
        195                 200                 205             


Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro 
    210                 215                 220                 


Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln 
225                 230                 235                 240 


Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser 
                245                 250                 255     


Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Thr Val Leu Ser Gln 
            260                 265                 270         


Val Pro Lys Ala Thr Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val 
        275                 280                 285             


Thr His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro 
    290                 295                 300                 


Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro 
305                 310                 315                 320 


Gln Ser Glu Thr Ile Ser Ser Pro Met Pro Gln Thr His Val Ser Gly 
                325                 330                 335     


Thr Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Thr Val Ser Ala 
            340                 345                 350         


Pro Ala Asn Val Asn Thr Thr Ser Ala Pro Pro Val Gln Thr Asp Ile 
        355                 360                 365             


Val Asn Thr Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met 
    370                 375                 380                 


Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu 
385                 390                 395                 400 


Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu 
                405                 410                 415     


Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu 
            420                 425                 430         


Gln Leu Asn Phe Ser Asn Thr Thr Ile Ser Leu Thr Ser Pro Ser Leu 
        435                 440                 445             


Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Thr Thr Thr 
    450                 455                 460                 


Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Thr Gln 
465                 470                 475                 480 


Ala Pro Glu Asn Ser Ile Gly Thr Ile Thr Leu Pro Ser Ser Leu Met 
                485                 490                 495     


Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe 
            500                 505                 510         


Asn Phe Phe Glu Thr Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn 
        515                 520                 525             


Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Thr 
    530                 535                 540                 


Val Arg Asn Leu Thr Arg Asn Val Thr Val Thr Leu Lys His Ile Asn 
545                 550                 555                 560 


Pro Ser Gln Asp Glu Leu Thr Val Arg Cys Val Phe Trp Asp Leu Gly 
                565                 570                 575     


Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys 
            580                 585                 590         


Asp Arg Arg Leu Asn Glu Thr Ile Cys Thr Cys Ser His Leu Thr Ser 
        595                 600                 605             


Phe Gly Val Leu Leu Asp Leu Ser Arg Thr Ser Val Leu Pro Ala Gln 
    610                 615                 620                 


Met Met Ala Leu Thr Phe Ile Thr Tyr Ile Gly Cys Gly Leu Ser Ser 
625                 630                 635                 640 


Ile Phe Leu Ser Val Thr Leu Val Thr Tyr Ile Ala Phe Glu Lys Ile 
                645                 650                 655     


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu 
            660                 665                 670         


Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr 
        675                 680                 685             


Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe 
    690                 695                 700                 


Leu Leu Val Ser Phe Thr Trp Met Gly Leu Glu Ala Phe His Met Tyr 
705                 710                 715                 720 


Leu Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Lys Tyr Ile Leu 
                725                 730                 735     


Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val Thr Ile 
            740                 745                 750         


Ile Leu Thr Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys 
        755                 760                 765             


Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala 
    770                 775                 780                 


Val Phe Tyr Ile Thr Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu 
785                 790                 795                 800 


Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys 
                805                 810                 815     


Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Thr Ser Ile Gln Asp Leu 
            820                 825                 830         


Arg Ser Ile Ala Gly Leu Thr Phe Leu Leu Gly Ile Thr Trp Gly Phe 
        835                 840                 845             


Ala Phe Phe Ala Trp Gly Pro Val Asn Val Thr Phe Met Tyr Leu Phe 
    850                 855                 860                 


Ala Ile Phe Asn Thr Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys 
865                 870                 875                 880 


Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys 
                885                 890                 895     


Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Thr Ala Thr 
            900                 905                 910         


Asn Gly Leu Lys Lys Gln Thr Val Asn Gln Gly Val Ser Ser Ser Ser 
        915                 920                 925             


Asn Ser Leu Gln Ser Ser Ser Asn Ser Thr Asn Ser Thr Thr Leu Leu 
    930                 935                 940                 


Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn Ala Ser 
945                 950                 955                 960 


Thr Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys 
                965                 970                 975     


Leu His Asp Phe Thr Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp 
            980                 985                 990         


Ser Cys Asn Gly Lys Gly Arg Met  Ala Leu Arg Arg Thr  Ser Lys Arg 
        995                 1000                 1005             


Gly Ser  Leu His Phe Ile Glu  Gln Met 
    1010                 1015         


<210>  269
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRG3__Homo_sapiens__NP_740746

<400>  269

Met Ala Thr Pro Arg Gly Leu Gly Ala Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Thr Ser Gly Gln Glu Lys Pro Thr Glu Gly Pro Arg Asn Thr Cys 
            20                  25                  30          


Leu Gly Ser Asn Asn Met Tyr Asp Ile Phe Asn Leu Asn Asp Lys Ala 
        35                  40                  45              


Leu Cys Phe Thr Lys Cys Arg Gln Ser Gly Ser Asp Ser Cys Asn Val 
    50                  55                  60                  


Glu Asn Leu Gln Arg Tyr Trp Leu Asn Tyr Glu Ala His Leu Met Lys 
65                  70                  75                  80  


Glu Gly Leu Thr Gln Lys Val Asn Thr Pro Phe Leu Lys Ala Leu Val 
                85                  90                  95      


Gln Asn Leu Ser Thr Asn Thr Ala Glu Asp Phe Tyr Phe Ser Leu Glu 
            100                 105                 110         


Pro Ser Gln Val Pro Arg Gln Val Met Lys Asp Glu Asp Lys Pro Pro 
        115                 120                 125             


Asp Arg Val Arg Leu Pro Lys Ser Leu Phe Arg Ser Leu Pro Gly Asn 
    130                 135                 140                 


Arg Ser Val Val Arg Leu Ala Val Thr Ile Leu Asp Ile Gly Pro Gly 
145                 150                 155                 160 


Thr Leu Phe Lys Gly Pro Arg Leu Gly Leu Gly Asp Gly Ser Gly Val 
                165                 170                 175     


Leu Asn Asn Arg Leu Val Gly Leu Ser Val Gly Gln Met His Val Thr 
            180                 185                 190         


Lys Leu Ala Glu Pro Leu Glu Ile Val Phe Ser His Gln Arg Pro Pro 
        195                 200                 205             


Pro Asn Met Thr Leu Thr Cys Val Phe Trp Asp Val Thr Lys Gly Thr 
    210                 215                 220                 


Thr Gly Asp Trp Ser Ser Glu Gly Cys Ser Thr Glu Val Arg Pro Glu 
225                 230                 235                 240 


Gly Thr Val Cys Cys Cys Asp His Leu Thr Phe Phe Ala Leu Leu Leu 
                245                 250                 255     


Arg Pro Thr Leu Asp Gln Ser Thr Val His Ile Leu Thr Arg Ile Ser 
            260                 265                 270         


Gln Ala Gly Cys Gly Val Ser Met Ile Phe Leu Ala Phe Thr Ile Ile 
        275                 280                 285             


Leu Tyr Ala Phe Leu Arg Leu Ser Arg Glu Arg Phe Lys Ser Glu Asp 
    290                 295                 300                 


Ala Pro Lys Ile His Val Ala Leu Gly Gly Ser Leu Phe Leu Leu Asn 
305                 310                 315                 320 


Leu Ala Phe Leu Val Asn Val Gly Ser Gly Ser Lys Gly Ser Asp Ala 
                325                 330                 335     


Ala Cys Trp Ala Arg Gly Ala Val Phe His Tyr Phe Leu Leu Cys Ala 
            340                 345                 350         


Phe Thr Trp Met Gly Leu Glu Ala Phe His Leu Tyr Leu Leu Ala Val 
        355                 360                 365             


Arg Val Phe Asn Thr Tyr Phe Gly His Tyr Phe Leu Lys Leu Ser Leu 
    370                 375                 380                 


Val Gly Trp Gly Leu Pro Ala Leu Met Val Ile Gly Thr Gly Ser Ala 
385                 390                 395                 400 


Asn Ser Tyr Gly Leu Tyr Thr Ile Arg Asp Arg Glu Asn Arg Thr Ser 
                405                 410                 415     


Leu Glu Leu Cys Trp Phe Arg Glu Gly Thr Thr Met Tyr Ala Leu Tyr 
            420                 425                 430         


Ile Thr Val His Gly Tyr Phe Leu Ile Thr Phe Leu Phe Gly Met Val 
        435                 440                 445             


Val Leu Ala Leu Val Val Trp Lys Ile Phe Thr Leu Ser Arg Ala Thr 
    450                 455                 460                 


Ala Val Lys Glu Arg Gly Lys Asn Arg Lys Lys Val Leu Thr Leu Leu 
465                 470                 475                 480 


Gly Leu Ser Ser Leu Val Gly Val Thr Trp Gly Leu Ala Ile Phe Thr 
                485                 490                 495     


Pro Leu Gly Leu Ser Thr Val Tyr Ile Phe Ala Leu Phe Asn Ser Leu 
            500                 505                 510         


Gln Gly Val Phe Ile Cys Cys Trp Phe Thr Ile Leu Tyr Leu Pro Ser 
        515                 520                 525             


Gln Ser Thr Thr Val Ser Ser Ser Thr Ala Arg Leu Asp Gln Ala His 
    530                 535                 540                 


Ser Ala Ser Gln Glu 
545                 


<210>  270
<211>  1193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRG6__Homo_sapiens__NP_001027566

<400>  270

Met Met Phe Arg Ser Asp Arg Met Trp Ser Cys His Trp Lys Trp Lys 
1               5                   10                  15      


Pro Ser Pro Leu Leu Phe Leu Phe Ala Leu Tyr Ile Met Cys Val Pro 
            20                  25                  30          


His Ser Val Trp Gly Cys Ala Asn Cys Arg Val Val Leu Ser Asn Pro 
        35                  40                  45              


Ser Gly Thr Phe Thr Ser Pro Cys Tyr Pro Asn Asp Tyr Pro Asn Ser 
    50                  55                  60                  


Gln Ala Cys Met Trp Thr Leu Arg Ala Pro Thr Gly Tyr Ile Ile Gln 
65                  70                  75                  80  


Ile Thr Phe Asn Asp Phe Asp Ile Glu Glu Ala Pro Asn Cys Ile Tyr 
                85                  90                  95      


Asp Ser Leu Ser Leu Asp Asn Gly Glu Ser Gln Thr Lys Phe Cys Gly 
            100                 105                 110         


Ala Thr Ala Lys Gly Leu Ser Phe Asn Ser Ser Ala Asn Glu Met His 
        115                 120                 125             


Val Ser Phe Ser Ser Asp Phe Ser Ile Gln Lys Lys Gly Phe Asn Ala 
    130                 135                 140                 


Ser Tyr Ile Arg Val Ala Val Ser Leu Arg Asn Gln Lys Val Ile Leu 
145                 150                 155                 160 


Pro Gln Thr Ser Asp Ala Tyr Gln Val Ser Val Ala Lys Ser Ile Ser 
                165                 170                 175     


Ile Pro Glu Leu Ser Ala Phe Thr Leu Cys Phe Glu Ala Thr Lys Val 
            180                 185                 190         


Gly His Glu Asp Ser Asp Trp Thr Ala Phe Ser Tyr Ser Asn Ala Ser 
        195                 200                 205             


Phe Thr Gln Leu Leu Ser Phe Gly Lys Ala Lys Ser Gly Tyr Phe Leu 
    210                 215                 220                 


Ser Ile Ser Asp Ser Lys Cys Leu Leu Asn Asn Ala Leu Pro Val Lys 
225                 230                 235                 240 


Glu Lys Glu Asp Ile Phe Ala Glu Ser Phe Glu Gln Leu Cys Leu Val 
                245                 250                 255     


Trp Asn Asn Ser Leu Gly Ser Ile Gly Val Asn Phe Lys Arg Asn Tyr 
            260                 265                 270         


Glu Thr Val Pro Cys Asp Ser Thr Ile Ser Lys Val Ile Pro Gly Asn 
        275                 280                 285             


Gly Lys Leu Leu Leu Gly Ser Asn Gln Asn Glu Ile Val Ser Leu Lys 
    290                 295                 300                 


Gly Asp Ile Tyr Asn Phe Arg Leu Trp Asn Phe Thr Met Asn Ala Lys 
305                 310                 315                 320 


Ile Leu Ser Asn Leu Ser Cys Asn Val Lys Gly Asn Val Val Asp Trp 
                325                 330                 335     


Gln Asn Asp Phe Trp Asn Ile Pro Asn Leu Ala Leu Lys Ala Glu Ser 
            340                 345                 350         


Asn Leu Ser Cys Gly Ser Tyr Leu Ile Pro Leu Pro Ala Ala Glu Leu 
        355                 360                 365             


Ala Ser Cys Ala Asp Leu Gly Thr Leu Cys Gln Asp Gly Ile Ile Tyr 
    370                 375                 380                 


Arg Ile Ser Val Val Ile Gln Asn Ile Leu Arg His Pro Glu Val Lys 
385                 390                 395                 400 


Val Gln Ser Lys Val Ala Glu Trp Leu Asn Ser Thr Phe Gln Asn Trp 
                405                 410                 415     


Asn Tyr Thr Val Tyr Val Val Asn Ile Ser Phe His Leu Ser Ala Gly 
            420                 425                 430         


Glu Asp Lys Ile Lys Val Lys Arg Ser Leu Glu Asp Glu Pro Arg Leu 
        435                 440                 445             


Val Leu Trp Ala Leu Leu Val Tyr Asn Ala Thr Asn Asn Thr Asn Leu 
    450                 455                 460                 


Glu Gly Lys Ile Ile Gln Gln Lys Leu Leu Lys Asn Asn Glu Ser Leu 
465                 470                 475                 480 


Asp Glu Gly Leu Arg Leu His Thr Val Asn Val Arg Gln Leu Gly His 
                485                 490                 495     


Cys Leu Ala Met Glu Glu Pro Lys Gly Tyr Tyr Trp Pro Ser Ile Gln 
            500                 505                 510         


Pro Ser Glu Tyr Val Leu Pro Cys Pro Asp Lys Pro Gly Phe Ser Ala 
        515                 520                 525             


Ser Arg Ile Cys Phe Tyr Asn Ala Thr Asn Pro Leu Val Thr Tyr Trp 
    530                 535                 540                 


Gly Pro Val Asp Ile Ser Asn Cys Leu Lys Glu Ala Asn Glu Val Ala 
545                 550                 555                 560 


Asn Gln Ile Leu Asn Leu Thr Ala Asp Gly Gln Asn Leu Thr Ser Ala 
                565                 570                 575     


Asn Ile Thr Asn Ile Val Glu Gln Val Lys Arg Ile Val Asn Lys Glu 
            580                 585                 590         


Glu Asn Ile Asp Ile Thr Leu Gly Ser Thr Leu Met Asn Ile Phe Ser 
        595                 600                 605             


Asn Ile Leu Ser Ser Ser Asp Ser Asp Leu Leu Glu Ser Ser Ser Glu 
    610                 615                 620                 


Ala Leu Lys Thr Ile Asp Glu Leu Ala Phe Lys Ile Asp Leu Asn Ser 
625                 630                 635                 640 


Thr Ser His Val Asn Ile Thr Thr Arg Asn Leu Ala Leu Ser Val Ser 
                645                 650                 655     


Ser Leu Leu Pro Gly Thr Asn Ala Ile Ser Asn Phe Ser Ile Gly Leu 
            660                 665                 670         


Pro Ser Asn Asn Glu Ser Tyr Phe Gln Met Asp Phe Glu Ser Gly Gln 
        675                 680                 685             


Val Asp Pro Leu Ala Ser Val Ile Leu Pro Pro Asn Leu Leu Glu Asn 
    690                 695                 700                 


Leu Ser Pro Glu Asp Ser Val Leu Val Arg Arg Ala Gln Phe Thr Phe 
705                 710                 715                 720 


Phe Asn Lys Thr Gly Leu Phe Gln Asp Val Gly Pro Gln Arg Lys Thr 
                725                 730                 735     


Leu Val Ser Tyr Val Met Ala Cys Ser Ile Gly Asn Ile Thr Ile Gln 
            740                 745                 750         


Asn Leu Lys Asp Pro Val Gln Ile Lys Ile Lys His Thr Arg Thr Gln 
        755                 760                 765             


Glu Val His His Pro Ile Cys Ala Phe Trp Asp Leu Asn Lys Asn Lys 
    770                 775                 780                 


Ser Phe Gly Gly Trp Asn Thr Ser Gly Cys Val Ala His Arg Asp Ser 
785                 790                 795                 800 


Asp Ala Ser Glu Thr Val Cys Leu Cys Asn His Phe Thr His Phe Gly 
                805                 810                 815     


Val Leu Met Asp Leu Pro Arg Ser Ala Ser Gln Leu Asp Ala Arg Asn 
            820                 825                 830         


Thr Lys Val Leu Thr Phe Ile Ser Tyr Ile Gly Cys Gly Ile Ser Ala 
        835                 840                 845             


Ile Phe Ser Ala Ala Thr Leu Leu Thr Tyr Val Ala Phe Glu Lys Leu 
    850                 855                 860                 


Arg Arg Asp Tyr Pro Ser Lys Ile Leu Met Asn Leu Ser Thr Ala Leu 
865                 870                 875                 880 


Leu Phe Leu Asn Leu Leu Phe Leu Leu Asp Gly Trp Ile Thr Ser Phe 
                885                 890                 895     


Asn Val Asp Gly Leu Cys Ile Ala Val Ala Val Leu Leu His Phe Phe 
            900                 905                 910         


Leu Leu Ala Thr Phe Thr Trp Met Gly Leu Glu Ala Ile His Met Tyr 
        915                 920                 925             


Ile Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Arg Tyr Ile Leu 
    930                 935                 940                 


Lys Phe Cys Ile Ile Gly Trp Gly Leu Pro Ala Leu Val Val Ser Val 
945                 950                 955                 960 


Val Leu Ala Ser Arg Asn Asn Asn Glu Val Tyr Gly Lys Glu Ser Tyr 
                965                 970                 975     


Gly Lys Glu Lys Gly Asp Glu Phe Cys Trp Ile Gln Asp Pro Val Ile 
            980                 985                 990         


Phe Tyr Val Thr Cys Ala Gly Tyr  Phe Gly Val Met Phe  Phe Leu Asn 
        995                 1000                 1005             


Ile Ala  Met Phe Ile Val Val  Met Val Gln Ile Cys  Gly Arg Asn 
    1010                 1015                 1020             


Gly Lys  Arg Ser Asn Arg Thr  Leu Arg Glu Glu Val  Leu Arg Asn 
    1025                 1030                 1035             


Leu Arg  Ser Val Val Ser Leu  Thr Phe Leu Leu Gly  Met Thr Trp 
    1040                 1045                 1050             


Gly Phe  Ala Phe Phe Ala Trp  Gly Pro Leu Asn Ile  Pro Phe Met 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Ile Phe Asn  Ser Leu Gln Gly Leu  Phe Ile Phe 
    1070                 1075                 1080             


Ile Phe  His Cys Ala Met Lys  Glu Asn Val Gln Lys  Gln Trp Arg 
    1085                 1090                 1095             


Arg His  Leu Cys Cys Gly Arg  Phe Arg Leu Ala Asp  Asn Ser Asp 
    1100                 1105                 1110             


Trp Ser  Lys Thr Ala Thr Asn  Ile Ile Lys Lys Ser  Ser Asp Asn 
    1115                 1120                 1125             


Leu Gly  Lys Ser Leu Ser Ser  Ser Ser Ile Gly Ser  Asn Ser Thr 
    1130                 1135                 1140             


Tyr Leu  Thr Ser Lys Ser Lys  Ser Ser Ser Thr Thr  Tyr Phe Lys 
    1145                 1150                 1155             


Arg Asn  Ser His Thr Asp Asn  Val Ser Tyr Glu His  Ser Phe Asn 
    1160                 1165                 1170             


Lys Ser  Gly Ser Leu Arg Gln  Cys Phe His Gly Gln  Val Leu Val 
    1175                 1180                 1185             


Lys Thr  Gly Pro Cys 
    1190             


<210>  271
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRG7__Homo_sapiens__NP_116176

<400>  271

Met Ala Ser Cys Arg Ala Trp Asn Leu Arg Val Leu Val Ala Val Val 
1               5                   10                  15      


Cys Gly Leu Leu Thr Gly Ile Ile Leu Gly Leu Gly Ile Trp Arg Ile 
            20                  25                  30          


Val Ile Arg Ile Gln Arg Gly Lys Ser Thr Ser Ser Ser Ser Thr Pro 
        35                  40                  45              


Thr Glu Phe Cys Arg Asn Gly Gly Thr Trp Glu Asn Gly Arg Cys Ile 
    50                  55                  60                  


Cys Thr Glu Glu Trp Lys Gly Leu Arg Cys Thr Ile Ala Asn Phe Cys 
65                  70                  75                  80  


Glu Asn Ser Thr Tyr Met Gly Phe Thr Phe Ala Arg Ile Pro Val Gly 
                85                  90                  95      


Arg Tyr Gly Pro Ser Leu Gln Thr Cys Gly Lys Asp Thr Pro Asn Ala 
            100                 105                 110         


Gly Asn Pro Met Ala Val Arg Leu Cys Ser Leu Ser Leu Tyr Gly Glu 
        115                 120                 125             


Ile Glu Leu Gln Lys Val Thr Ile Gly Asn Cys Asn Glu Asn Leu Glu 
    130                 135                 140                 


Thr Leu Glu Lys Gln Val Lys Asp Val Thr Ala Pro Leu Asn Asn Ile 
145                 150                 155                 160 


Ser Ser Glu Val Gln Ile Leu Thr Ser Asp Ala Asn Lys Leu Thr Ala 
                165                 170                 175     


Glu Asn Ile Thr Ser Ala Thr Arg Val Val Gly Gln Ile Phe Asn Thr 
            180                 185                 190         


Ser Arg Asn Ala Ser Pro Glu Ala Lys Lys Val Ala Ile Val Thr Val 
        195                 200                 205             


Ser Gln Leu Leu Asp Ala Ser Glu Asp Ala Phe Gln Arg Val Ala Ala 
    210                 215                 220                 


Thr Ala Asn Asp Asp Ala Leu Thr Thr Leu Ile Glu Gln Met Glu Thr 
225                 230                 235                 240 


Tyr Ser Leu Ser Leu Gly Asn Gln Ser Val Val Glu Pro Asn Ile Ala 
                245                 250                 255     


Ile Gln Ser Ala Asn Phe Ser Ser Glu Asn Ala Val Gly Pro Ser Asn 
            260                 265                 270         


Val Arg Phe Ser Val Gln Lys Gly Ala Ser Ser Ser Leu Val Ser Ser 
        275                 280                 285             


Ser Thr Phe Ile His Thr Asn Val Asp Gly Leu Asn Pro Asp Ala Gln 
    290                 295                 300                 


Thr Glu Leu Gln Val Leu Leu Asn Met Thr Lys Asn Tyr Thr Lys Thr 
305                 310                 315                 320 


Cys Gly Phe Val Val Tyr Gln Asn Asp Lys Leu Phe Gln Ser Lys Thr 
                325                 330                 335     


Phe Thr Ala Lys Ser Asp Phe Ser Gln Lys Ile Ile Ser Ser Lys Thr 
            340                 345                 350         


Asp Glu Asn Glu Gln Asp Gln Ser Ala Ser Val Asp Met Val Phe Ser 
        355                 360                 365             


Pro Lys Tyr Asn Gln Lys Glu Phe Gln Leu Tyr Ser Tyr Ala Cys Val 
    370                 375                 380                 


Tyr Trp Asn Leu Ser Ala Lys Asp Trp Asp Thr Tyr Gly Cys Gln Lys 
385                 390                 395                 400 


Asp Lys Gly Thr Asp Gly Phe Leu Arg Cys Arg Cys Asn His Thr Thr 
                405                 410                 415     


Asn Phe Ala Val Leu Met Thr Phe Lys Lys Asp Tyr Gln Tyr Pro Lys 
            420                 425                 430         


Ser Leu Asp Ile Leu Ser Asn Val Gly Cys Ala Leu Ser Val Thr Gly 
        435                 440                 445             


Leu Ala Leu Thr Val Ile Phe Gln Ile Val Thr Arg Lys Val Arg Lys 
    450                 455                 460                 


Thr Ser Val Thr Trp Val Leu Val Asn Leu Cys Ile Ser Met Leu Ile 
465                 470                 475                 480 


Phe Asn Leu Leu Phe Val Phe Gly Ile Glu Asn Ser Asn Lys Asn Leu 
                485                 490                 495     


Gln Thr Ser Asp Gly Asp Ile Asn Asn Ile Asp Phe Asp Asn Asn Asp 
            500                 505                 510         


Ile Pro Arg Thr Asp Thr Ile Asn Ile Pro Asn Pro Met Cys Thr Ala 
        515                 520                 525             


Ile Ala Ala Leu Leu His Tyr Phe Leu Leu Val Thr Phe Thr Trp Asn 
    530                 535                 540                 


Ala Leu Ser Ala Ala Gln Leu Tyr Tyr Leu Leu Ile Arg Thr Met Lys 
545                 550                 555                 560 


Pro Leu Pro Arg His Phe Ile Leu Phe Ile Ser Leu Ile Gly Trp Gly 
                565                 570                 575     


Val Pro Ala Ile Val Val Ala Ile Thr Val Gly Val Ile Tyr Ser Gln 
            580                 585                 590         


Asn Gly Asn Asn Pro Gln Trp Glu Leu Asp Tyr Arg Gln Glu Lys Ile 
        595                 600                 605             


Cys Trp Leu Ala Ile Pro Glu Pro Asn Gly Val Ile Lys Ser Pro Leu 
    610                 615                 620                 


Leu Trp Ser Phe Ile Val Pro Val Thr Ile Ile Leu Ile Ser Asn Val 
625                 630                 635                 640 


Val Met Phe Ile Thr Ile Ser Ile Lys Val Leu Trp Lys Asn Asn Gln 
                645                 650                 655     


Asn Leu Thr Ser Thr Lys Lys Val Ser Ser Met Lys Lys Ile Val Ser 
            660                 665                 670         


Thr Leu Ser Val Ala Val Val Phe Gly Ile Thr Trp Ile Leu Ala Tyr 
        675                 680                 685             


Leu Met Leu Val Asn Asp Asp Ser Ile Arg Ile Val Phe Ser Tyr Ile 
    690                 695                 700                 


Phe Cys Leu Phe Asn Thr Thr Gln Gly Leu Gln Ile Phe Ile Leu Tyr 
705                 710                 715                 720 


Thr Val Arg Thr Lys Val Phe Gln Ser Glu Ala Ser Lys Val Leu Met 
                725                 730                 735     


Leu Leu Ser Ser Ile Gly Arg Arg Lys Ser Leu Pro Ser Val Thr Arg 
            740                 745                 750         


Pro Arg Leu Arg Val Lys Met Tyr Asn Phe Leu Arg Ser Leu Pro Thr 
        755                 760                 765             


Leu His Glu Arg Phe Arg Leu Leu Glu Thr Ser Pro Ser Thr Glu Glu 
    770                 775                 780                 


Ile Thr Leu Ser Glu Ser Asp Asn Ala Lys Glu Ser Ile 
785                 790                 795         


<210>  272
<211>  1474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRL1__Homo_sapiens__NP_001008701

<400>  272

Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Thr Ala Val 
1               5                   10                  15      


Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
            20                  25                  30          


Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
        35                  40                  45              


Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
    50                  55                  60                  


Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
65                  70                  75                  80  


Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                85                  90                  95      


Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
            100                 105                 110         


Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
        115                 120                 125             


Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
    130                 135                 140                 


Gln Lys Val Leu Glu Pro Thr Ser Thr His Glu Ser Glu His Gln Ser 
145                 150                 155                 160 


Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val 
                165                 170                 175     


Met Pro Trp Ile Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser 
            180                 185                 190         


Trp Glu Asp Tyr Val Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro 
        195                 200                 205             


Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
    210                 215                 220                 


Tyr Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr 
225                 230                 235                 240 


Arg Ile Lys Ser Gly Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp 
                245                 250                 255     


Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
            260                 265                 270         


Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly 
        275                 280                 285             


Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly 
    290                 295                 300                 


Thr Trp Glu Thr Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met 
305                 310                 315                 320 


Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp 
                325                 330                 335     


Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala 
            340                 345                 350         


Asn Arg Glu Glu Pro Val Ser Leu Thr Phe Pro Asn Pro Tyr Gln Phe 
        355                 360                 365             


Ile Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
    370                 375                 380                 


Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
385                 390                 395                 400 


Pro Ser Ala Gly Pro Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr 
                405                 410                 415     


Ala Arg Pro Thr Pro Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr 
            420                 425                 430         


Pro Leu Arg Arg Ala Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn 
        435                 440                 445             


Gln Leu Gly Pro Asp Leu Pro Pro Ala Thr Ala Pro Val Pro Ser Thr 
    450                 455                 460                 


Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys 
465                 470                 475                 480 


Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly 
                485                 490                 495     


Met Leu Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser 
            500                 505                 510         


Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp 
        515                 520                 525             


Leu Ser Asn Cys Thr Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile 
    530                 535                 540                 


Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His 
545                 550                 555                 560 


Thr Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu 
                565                 570                 575     


Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg 
            580                 585                 590         


Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys 
        595                 600                 605             


Arg Glu Arg Thr Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val 
    610                 615                 620                 


Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn 
625                 630                 635                 640 


Ala Thr Glu Gln Val His Thr Ala Thr Met Leu Leu Asp Val Leu Glu 
                645                 650                 655     


Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe 
            660                 665                 670         


Leu Ala Ala Lys Glu Asn Val Val Leu Glu Val Thr Val Leu Asn Thr 
        675                 680                 685             


Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg 
    690                 695                 700                 


Lys Asn Ser Ile Gln Leu Ser Ala Lys Thr Ile Lys Gln Asn Ser Arg 
705                 710                 715                 720 


Asn Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu 
                725                 730                 735     


Phe Leu Ser Thr Glu Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly 
            740                 745                 750         


Pro Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile 
        755                 760                 765             


Ala Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro 
    770                 775                 780                 


Val Ile Phe Thr Val Ala His Leu Glu Asp Lys Asn His Phe Asn Ala 
785                 790                 795                 800 


Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp 
                805                 810                 815     


Ser Thr Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr 
            820                 825                 830         


Cys Ala Cys Ser His Leu Thr Asn Phe Ala Val Leu Met Ala His Arg 
        835                 840                 845             


Glu Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr 
    850                 855                 860                 


Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser 
865                 870                 875                 880 


Thr Phe Cys Phe Leu Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His 
                885                 890                 895     


Lys Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val 
            900                 905                 910         


Gly Ile Asp Lys Thr Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly 
        915                 920                 925             


Leu Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu 
    930                 935                 940                 


Gly Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr 
945                 950                 955                 960 


Ser Arg Thr Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu 
                965                 970                 975     


Val Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu 
            980                 985                 990         


Lys Ala Cys Trp Leu Arg Val Asp  Asn Tyr Phe Ile Trp  Ser Phe Ile 
        995                 1000                 1005             


Gly Pro  Val Ser Phe Val Ile  Val Val Asn Leu Val  Phe Leu Met 
    1010                 1015                 1020             


Val Thr  Leu His Lys Met Ile  Arg Ser Ser Ser Val  Leu Lys Pro 
    1025                 1030                 1035             


Asp Ser  Ser Arg Leu Asp Asn  Ile Lys Ser Trp Ala  Leu Gly Ala 
    1040                 1045                 1050             


Ile Ala  Leu Leu Phe Leu Leu  Gly Leu Thr Trp Ala  Phe Gly Leu 
    1055                 1060                 1065             


Leu Phe  Ile Asn Lys Glu Ser  Val Val Met Ala Tyr  Leu Phe Thr 
    1070                 1075                 1080             


Thr Phe  Asn Ala Phe Gln Gly  Val Phe Ile Phe Val  Phe His Cys 
    1085                 1090                 1095             


Ala Leu  Gln Lys Lys Val His  Lys Glu Tyr Ser Lys  Cys Leu Arg 
    1100                 1105                 1110             


His Ser  Tyr Cys Cys Ile Arg  Ser Pro Pro Gly Gly  Thr His Gly 
    1115                 1120                 1125             


Ser Leu  Lys Thr Ser Ala Met  Arg Ser Asn Thr Arg  Tyr Tyr Thr 
    1130                 1135                 1140             


Gly Thr  Gln Ser Arg Ile Arg  Arg Met Trp Asn Asp  Thr Val Arg 
    1145                 1150                 1155             


Lys Gln  Thr Glu Ser Ser Phe  Met Ala Gly Asp Ile  Asn Ser Thr 
    1160                 1165                 1170             


Pro Thr  Leu Asn Arg Gly Thr  Met Gly Asn His Leu  Leu Thr Asn 
    1175                 1180                 1185             


Pro Val  Leu Gln Pro Arg Gly  Gly Thr Ser Pro Tyr  Asn Thr Leu 
    1190                 1195                 1200             


Ile Ala  Glu Ser Val Gly Phe  Asn Pro Ser Ser Pro  Pro Val Phe 
    1205                 1210                 1215             


Asn Ser  Pro Gly Ser Tyr Arg  Glu Pro Lys His Pro  Leu Gly Gly 
    1220                 1225                 1230             


Arg Glu  Ala Cys Gly Met Asp  Thr Leu Pro Leu Asn  Gly Asn Phe 
    1235                 1240                 1245             


Asn Asn  Ser Tyr Ser Leu Arg  Ser Gly Asp Phe Pro  Pro Gly Asp 
    1250                 1255                 1260             


Gly Gly  Pro Glu Pro Pro Arg  Gly Arg Asn Leu Ala  Asp Ala Ala 
    1265                 1270                 1275             


Ala Phe  Glu Lys Met Ile Ile  Ser Glu Leu Val His  Asn Asn Leu 
    1280                 1285                 1290             


Arg Gly  Ser Ser Ser Ala Ala  Lys Gly Pro Pro Pro  Pro Glu Pro 
    1295                 1300                 1305             


Pro Val  Pro Pro Val Pro Gly  Gly Gly Gly Glu Glu  Glu Ala Gly 
    1310                 1315                 1320             


Gly Pro  Gly Gly Ala Asp Arg  Ala Glu Ile Glu Leu  Leu Tyr Lys 
    1325                 1330                 1335             


Ala Leu  Glu Glu Pro Leu Leu  Leu Pro Arg Ala Gln  Ser Val Leu 
    1340                 1345                 1350             


Tyr Gln  Ser Asp Leu Asp Glu  Ser Glu Ser Cys Thr  Ala Glu Asp 
    1355                 1360                 1365             


Gly Ala  Thr Ser Arg Pro Leu  Ser Ser Pro Pro Gly  Arg Asp Ser 
    1370                 1375                 1380             


Leu Tyr  Ala Ser Gly Ala Asn  Leu Arg Asp Ser Pro  Ser Tyr Pro 
    1385                 1390                 1395             


Asp Ser  Ser Pro Glu Gly Pro  Ser Glu Ala Leu Pro  Pro Pro Pro 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Pro Pro  Glu Ile Tyr Tyr Thr  Ser Arg Pro 
    1415                 1420                 1425             


Pro Ala  Leu Val Ala Arg Asn  Pro Leu Gln Gly Tyr  Tyr Gln Val 
    1430                 1435                 1440             


Arg Arg  Pro Ser His Glu Gly  Tyr Leu Ala Ala Pro  Gly Leu Glu 
    1445                 1450                 1455             


Gly Pro  Gly Pro Asp Gly Asp  Gly Gln Met Gln Leu  Val Thr Ser 
    1460                 1465                 1470             


Leu 
    


<210>  273
<211>  1469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRL3__Homo_sapiens__NP_056051

<400>  273

Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile 
1               5                   10                  15      


Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg 
            20                  25                  30          


Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Thr 
        35                  40                  45              


Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Thr Asp Asp Lys 
    50                  55                  60                  


Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu 
65                  70                  75                  80  


Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Thr Gln 
                85                  90                  95      


Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly 
            100                 105                 110         


Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val 
        115                 120                 125             


Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln 
    130                 135                 140                 


Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys 
145                 150                 155                 160 


Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Thr Pro 
                165                 170                 175     


Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys Asp Asp Phe Ile 
            180                 185                 190         


Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His Arg Val Asp Gly 
        195                 200                 205             


Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg 
    210                 215                 220                 


Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser Gly 
225                 230                 235                 240 


Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr Ser Pro Tyr Arg 
                245                 250                 255     


Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu 
            260                 265                 270         


Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys Ile Val Ile Ser 
        275                 280                 285             


Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr Trp Asp Thr Ala 
    290                 295                 300                 


Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu 
305                 310                 315                 320 


Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Thr Gly 
                325                 330                 335     


Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser Lys Asp Ser Leu 
            340                 345                 350         


Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp 
        355                 360                 365             


Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val 
    370                 375                 380                 


Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln 
385                 390                 395                 400 


Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp 
                405                 410                 415     


Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Thr Thr Gly Pro 
            420                 425                 430         


Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu Arg Thr Thr Thr 
        435                 440                 445             


Leu Ser Pro Gly Arg Ser Thr Thr Pro Ser Val Ser Gly Arg Arg Asn 
    450                 455                 460                 


Arg Ser Thr Ser Thr Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met 
465                 470                 475                 480 


Thr Thr His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu 
                485                 490                 495     


Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Thr Arg 
            500                 505                 510         


Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Thr Ile Gly Val 
        515                 520                 525             


Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly 
    530                 535                 540                 


Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Thr Gln 
545                 550                 555                 560 


Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg Glu Leu Ala 
                565                 570                 575     


Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr Tyr Ser Val 
            580                 585                 590         


Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn 
        595                 600                 605             


Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu 
    610                 615                 620                 


Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu 
625                 630                 635                 640 


Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp 
                645                 650                 655     


Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu Leu His Thr 
            660                 665                 670         


Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Thr Asp 
        675                 680                 685             


Ile Val Arg Glu Asn Thr Asp Asn Ile Lys Leu Glu Val Ala Arg Leu 
    690                 695                 700                 


Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly 
705                 710                 715                 720 


His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys Gln Asn Gly 
                725                 730                 735     


Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly 
            740                 745                 750         


Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly Thr Glu Ala 
        755                 760                 765             


Leu Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val Ile Thr Ala 
    770                 775                 780                 


Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val 
785                 790                 795                 800 


Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro 
                805                 810                 815     


Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr Gly Tyr Trp 
            820                 825                 830         


Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr His Thr Thr 
        835                 840                 845             


Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met Ala His Val 
    850                 855                 860                 


Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile 
865                 870                 875                 880 


Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile 
                885                 890                 895     


Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile 
            900                 905                 910         


His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu 
        915                 920                 925             


Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala Val Phe Ala 
    930                 935                 940                 


Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp Met Phe Leu 
945                 950                 955                 960 


Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu 
                965                 970                 975     


His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala 
            980                 985                 990         


Leu Ile Val Ala Val Ser Ala Ala  Val Asp Tyr Arg Ser  Tyr Gly Thr 
        995                 1000                 1005             


Asp Lys  Val Cys Trp Leu Arg  Leu Asp Thr Tyr Phe  Ile Trp Ser 
    1010                 1015                 1020             


Phe Ile  Gly Pro Ala Thr Leu  Ile Ile Met Leu Asn  Val Ile Phe 
    1025                 1030                 1035             


Leu Gly  Ile Ala Leu Tyr Lys  Met Phe His His Thr  Ala Ile Leu 
    1040                 1045                 1050             


Lys Pro  Glu Ser Gly Cys Leu  Asp Asn Ile Asn Tyr  Glu Asp Asn 
    1055                 1060                 1065             


Arg Pro  Phe Ile Lys Ser Trp  Val Ile Gly Ala Ile  Ala Leu Leu 
    1070                 1075                 1080             


Cys Leu  Leu Gly Leu Thr Trp  Ala Phe Gly Leu Met  Tyr Ile Asn 
    1085                 1090                 1095             


Glu Ser  Thr Val Ile Met Ala  Tyr Leu Phe Thr Ile  Phe Asn Ser 
    1100                 1105                 1110             


Leu Gln  Gly Met Phe Ile Phe  Ile Phe His Cys Val  Leu Gln Lys 
    1115                 1120                 1125             


Lys Val  Arg Lys Glu Tyr Gly  Lys Cys Leu Arg Thr  His Cys Cys 
    1130                 1135                 1140             


Ser Gly  Lys Ser Thr Glu Ser  Ser Ile Gly Ser Gly  Lys Thr Ser 
    1145                 1150                 1155             


Gly Ser  Arg Thr Pro Gly Arg  Tyr Ser Thr Gly Ser  Gln Ser Arg 
    1160                 1165                 1170             


Ile Arg  Arg Met Trp Asn Asp  Thr Val Arg Lys Gln  Ser Glu Ser 
    1175                 1180                 1185             


Ser Phe  Ile Thr Gly Asp Ile  Asn Ser Ser Ala Ser  Leu Asn Arg 
    1190                 1195                 1200             


Glu Gly  Leu Leu Asn Asn Ala  Arg Asp Thr Ser Val  Met Asp Thr 
    1205                 1210                 1215             


Leu Pro  Leu Asn Gly Asn His  Gly Asn Ser Tyr Ser  Ile Ala Ser 
    1220                 1225                 1230             


Gly Glu  Tyr Leu Ser Asn Cys  Val Gln Ile Ile Asp  Arg Gly Tyr 
    1235                 1240                 1245             


Asn His  Asn Glu Thr Ala Leu  Glu Lys Lys Ile Leu  Lys Glu Leu 
    1250                 1255                 1260             


Thr Ser  Asn Tyr Ile Pro Ser  Tyr Leu Asn Asn His  Glu Arg Ser 
    1265                 1270                 1275             


Ser Glu  Gln Asn Arg Asn Leu  Met Asn Lys Leu Val  Asn Asn Leu 
    1280                 1285                 1290             


Gly Ser  Gly Arg Glu Asp Asp  Ala Ile Val Leu Asp  Asp Ala Thr 
    1295                 1300                 1305             


Ser Phe  Asn His Glu Glu Ser  Leu Gly Leu Glu Leu  Ile His Glu 
    1310                 1315                 1320             


Glu Ser  Asp Ala Pro Leu Leu  Pro Pro Arg Val Tyr  Ser Thr Glu 
    1325                 1330                 1335             


Asn His  Gln Pro His His Tyr  Thr Arg Arg Arg Ile  Pro Gln Asp 
    1340                 1345                 1350             


His Ser  Glu Ser Phe Phe Pro  Leu Leu Thr Asn Glu  His Thr Glu 
    1355                 1360                 1365             


Asp Leu  Gln Ser Pro His Arg  Asp Ser Leu Tyr Thr  Ser Met Pro 
    1370                 1375                 1380             


Thr Leu  Ala Gly Val Ala Ala  Thr Glu Ser Val Thr  Thr Ser Thr 
    1385                 1390                 1395             


Gln Thr  Glu Pro Pro Pro Ala  Lys Cys Gly Asp Ala  Glu Asp Val 
    1400                 1405                 1410             


Tyr Tyr  Lys Ser Met Pro Asn  Leu Gly Ser Arg Asn  His Val His 
    1415                 1420                 1425             


Gln Leu  His Thr Tyr Tyr Gln  Leu Gly Arg Gly Ser  Ser Asp Gly 
    1430                 1435                 1440             


Phe Ile  Val Pro Pro Asn Lys  Asp Gly Thr Pro Pro  Glu Gly Ser 
    1445                 1450                 1455             


Ser Lys  Gly Pro Ala His Leu  Val Thr Ser Leu 
    1460                 1465                 


<210>  274
<211>  6306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADGRV1__Homo_sapiens__NP_115495

<400>  274

Met Ser Val Phe Leu Gly Pro Gly Met Pro Ser Ala Ser Leu Leu Val 
1               5                   10                  15      


Asn Leu Leu Ser Ala Leu Leu Ile Leu Phe Val Phe Gly Glu Thr Glu 
            20                  25                  30          


Ile Arg Phe Thr Gly Gln Thr Glu Phe Val Val Asn Glu Thr Ser Thr 
        35                  40                  45              


Thr Val Ile Arg Leu Ile Ile Glu Arg Ile Gly Glu Pro Ala Asn Val 
    50                  55                  60                  


Thr Ala Ile Val Ser Leu Tyr Gly Glu Asp Ala Gly Asp Phe Phe Asp 
65                  70                  75                  80  


Thr Tyr Ala Ala Ala Phe Ile Pro Ala Gly Glu Thr Asn Arg Thr Val 
                85                  90                  95      


Tyr Ile Ala Val Cys Asp Asp Asp Leu Pro Glu Pro Asp Glu Thr Phe 
            100                 105                 110         


Ile Phe His Leu Thr Leu Gln Lys Pro Ser Ala Asn Val Lys Leu Gly 
        115                 120                 125             


Trp Pro Arg Thr Val Thr Val Thr Ile Leu Ser Asn Asp Asn Ala Phe 
    130                 135                 140                 


Gly Ile Ile Ser Phe Asn Met Leu Pro Ser Ile Ala Val Ser Glu Pro 
145                 150                 155                 160 


Lys Gly Arg Asn Glu Ser Met Pro Leu Thr Leu Ile Arg Glu Lys Gly 
                165                 170                 175     


Thr Tyr Gly Met Val Met Val Thr Phe Glu Val Glu Gly Gly Pro Asn 
            180                 185                 190         


Pro Pro Asp Glu Asp Leu Ser Pro Val Lys Gly Asn Ile Thr Phe Pro 
        195                 200                 205             


Pro Gly Arg Ala Thr Val Ile Tyr Asn Leu Thr Val Leu Asp Asp Glu 
    210                 215                 220                 


Val Pro Glu Asn Asp Glu Ile Phe Leu Ile Gln Leu Lys Ser Val Glu 
225                 230                 235                 240 


Gly Gly Ala Glu Ile Asn Thr Ser Arg Asn Ser Ile Glu Ile Ile Ile 
                245                 250                 255     


Lys Lys Asn Asp Ser Pro Val Arg Phe Leu Gln Ser Ile Tyr Leu Val 
            260                 265                 270         


Pro Glu Glu Asp His Ile Leu Ile Ile Pro Val Val Arg Gly Lys Asp 
        275                 280                 285             


Asn Asn Gly Asn Leu Ile Gly Ser Asp Glu Tyr Glu Val Ser Ile Ser 
    290                 295                 300                 


Tyr Ala Val Thr Thr Gly Asn Ser Thr Ala His Ala Gln Gln Asn Leu 
305                 310                 315                 320 


Asp Phe Ile Asp Leu Gln Pro Asn Thr Thr Val Val Phe Pro Pro Phe 
                325                 330                 335     


Ile His Glu Ser His Leu Lys Phe Gln Ile Val Asp Asp Thr Ile Pro 
            340                 345                 350         


Glu Ile Ala Glu Ser Phe His Ile Met Leu Leu Lys Asp Thr Leu Gln 
        355                 360                 365             


Gly Asp Ala Val Leu Ile Ser Pro Ser Val Val Gln Val Thr Ile Lys 
    370                 375                 380                 


Pro Asn Asp Lys Pro Tyr Gly Val Leu Ser Phe Asn Ser Val Leu Phe 
385                 390                 395                 400 


Glu Arg Thr Val Ile Ile Asp Glu Asp Arg Ile Ser Arg Tyr Glu Glu 
                405                 410                 415     


Ile Thr Val Val Arg Asn Gly Gly Thr His Gly Asn Val Ser Ala Asn 
            420                 425                 430         


Trp Val Leu Thr Arg Asn Ser Thr Asp Pro Ser Pro Val Thr Ala Asp 
        435                 440                 445             


Ile Arg Pro Ser Ser Gly Val Leu His Phe Ala Gln Gly Gln Met Leu 
    450                 455                 460                 


Ala Thr Ile Pro Leu Thr Val Val Asp Asp Asp Leu Pro Glu Glu Ala 
465                 470                 475                 480 


Glu Ala Tyr Leu Leu Gln Ile Leu Pro His Thr Ile Arg Gly Gly Ala 
                485                 490                 495     


Glu Val Ser Glu Pro Ala Glu Leu Leu Phe Tyr Ile Gln Asp Ser Asp 
            500                 505                 510         


Asp Val Tyr Gly Leu Ile Thr Phe Phe Pro Met Glu Asn Gln Lys Ile 
        515                 520                 525             


Glu Ser Ser Pro Gly Glu Arg Tyr Leu Ser Leu Ser Phe Thr Arg Leu 
    530                 535                 540                 


Gly Gly Thr Lys Gly Asp Val Arg Leu Leu Tyr Ser Val Leu Tyr Ile 
545                 550                 555                 560 


Pro Ala Gly Ala Val Asp Pro Leu Gln Ala Lys Glu Gly Ile Leu Asn 
                565                 570                 575     


Ile Ser Arg Arg Asn Asp Leu Ile Phe Pro Glu Gln Lys Thr Gln Val 
            580                 585                 590         


Thr Thr Lys Leu Pro Ile Arg Asn Asp Ala Phe Leu Gln Asn Gly Ala 
        595                 600                 605             


His Phe Leu Val Gln Leu Glu Thr Val Glu Leu Leu Asn Ile Ile Pro 
    610                 615                 620                 


Leu Ile Pro Pro Ile Ser Pro Arg Phe Gly Glu Ile Cys Asn Ile Ser 
625                 630                 635                 640 


Leu Leu Val Thr Pro Ala Ile Ala Asn Gly Glu Ile Gly Phe Leu Ser 
                645                 650                 655     


Asn Leu Pro Ile Ile Leu His Glu Pro Glu Asp Phe Ala Ala Glu Val 
            660                 665                 670         


Val Tyr Ile Pro Leu His Arg Asp Gly Thr Asp Gly Gln Ala Thr Val 
        675                 680                 685             


Tyr Trp Ser Leu Lys Pro Ser Gly Phe Asn Ser Lys Ala Val Thr Pro 
    690                 695                 700                 


Asp Asp Ile Gly Pro Phe Asn Gly Ser Val Leu Phe Leu Ser Gly Gln 
705                 710                 715                 720 


Ser Asp Thr Thr Ile Asn Ile Thr Ile Lys Gly Asp Asp Ile Pro Glu 
                725                 730                 735     


Met Asn Glu Thr Val Thr Leu Ser Leu Asp Arg Val Asn Val Glu Asn 
            740                 745                 750         


Gln Val Leu Lys Ser Gly Tyr Thr Ser Arg Asp Leu Ile Ile Leu Glu 
        755                 760                 765             


Asn Asp Asp Pro Gly Gly Val Phe Glu Phe Ser Pro Ala Ser Arg Gly 
    770                 775                 780                 


Pro Tyr Val Ile Lys Glu Gly Glu Ser Val Glu Leu His Ile Ile Arg 
785                 790                 795                 800 


Ser Arg Gly Ser Leu Val Lys Gln Phe Leu His Tyr Arg Val Glu Pro 
                805                 810                 815     


Arg Asp Ser Asn Glu Phe Tyr Gly Asn Thr Gly Val Leu Glu Phe Lys 
            820                 825                 830         


Pro Gly Glu Arg Glu Ile Val Ile Thr Leu Leu Ala Arg Leu Asp Gly 
        835                 840                 845             


Ile Pro Glu Leu Asp Glu His Tyr Trp Val Val Leu Ser Ser His Gly 
    850                 855                 860                 


Glu Arg Glu Ser Lys Leu Gly Ser Ala Thr Ile Val Asn Ile Thr Ile 
865                 870                 875                 880 


Leu Lys Asn Asp Asp Pro His Gly Ile Ile Glu Phe Val Ser Asp Gly 
                885                 890                 895     


Leu Ile Val Met Ile Asn Glu Ser Lys Gly Asp Ala Ile Tyr Ser Ala 
            900                 905                 910         


Val Tyr Asp Val Val Arg Asn Arg Gly Asn Phe Gly Asp Val Ser Val 
        915                 920                 925             


Ser Trp Val Val Ser Pro Asp Phe Thr Gln Asp Val Phe Pro Val Gln 
    930                 935                 940                 


Gly Thr Val Val Phe Gly Asp Gln Glu Phe Ser Lys Asn Ile Thr Ile 
945                 950                 955                 960 


Tyr Ser Leu Pro Asp Glu Ile Pro Glu Glu Met Glu Glu Phe Thr Val 
                965                 970                 975     


Ile Leu Leu Asn Gly Thr Gly Gly Ala Lys Val Gly Asn Arg Thr Thr 
            980                 985                 990         


Ala Thr Leu Arg Ile Arg Arg Asn  Asp Asp Pro Ile Tyr  Phe Ala Glu 
        995                 1000                 1005             


Pro Arg  Val Val Arg Val Gln  Glu Gly Glu Thr Ala  Asn Phe Thr 
    1010                 1015                 1020             


Val Leu  Arg Asn Gly Ser Val  Asp Val Thr Cys Met  Val Gln Tyr 
    1025                 1030                 1035             


Ala Thr  Lys Asp Gly Lys Ala  Thr Ala Arg Glu Arg  Asp Phe Ile 
    1040                 1045                 1050             


Pro Val  Glu Lys Gly Glu Thr  Leu Ile Phe Glu Val  Gly Ser Arg 
    1055                 1060                 1065             


Gln Gln  Ser Ile Ser Ile Phe  Val Asn Glu Asp Gly  Ile Pro Glu 
    1070                 1075                 1080             


Thr Asp  Glu Pro Phe Tyr Ile  Ile Leu Leu Asn Ser  Thr Gly Asp 
    1085                 1090                 1095             


Thr Val  Val Tyr Gln Tyr Gly  Val Ala Thr Val Ile  Ile Glu Ala 
    1100                 1105                 1110             


Asn Asp  Asp Pro Asn Gly Ile  Phe Ser Leu Glu Pro  Ile Asp Lys 
    1115                 1120                 1125             


Ala Val  Glu Glu Gly Lys Thr  Asn Ala Phe Trp Ile  Leu Arg His 
    1130                 1135                 1140             


Arg Gly  Tyr Phe Gly Ser Val  Ser Val Ser Trp Gln  Leu Phe Gln 
    1145                 1150                 1155             


Asn Asp  Ser Ala Leu Gln Pro  Gly Gln Glu Phe Tyr  Glu Thr Ser 
    1160                 1165                 1170             


Gly Thr  Val Asn Phe Met Asp  Gly Glu Glu Ala Lys  Pro Ile Ile 
    1175                 1180                 1185             


Leu His  Ala Phe Pro Asp Lys  Ile Pro Glu Phe Asn  Glu Phe Tyr 
    1190                 1195                 1200             


Phe Leu  Lys Leu Val Asn Ile  Ser Gly Gly Ser Pro  Gly Pro Gly 
    1205                 1210                 1215             


Gly Gln  Leu Ala Glu Thr Asn  Leu Gln Val Thr Val  Met Val Pro 
    1220                 1225                 1230             


Phe Asn  Asp Asp Pro Phe Gly  Val Phe Ile Leu Asp  Pro Glu Cys 
    1235                 1240                 1245             


Leu Glu  Arg Glu Val Ala Glu  Asp Val Leu Ser Glu  Asp Asp Met 
    1250                 1255                 1260             


Ser Tyr  Ile Thr Asn Phe Thr  Ile Leu Arg Gln Gln  Gly Val Phe 
    1265                 1270                 1275             


Gly Asp  Val Gln Leu Gly Trp  Glu Ile Leu Ser Ser  Glu Phe Pro 
    1280                 1285                 1290             


Ala Gly  Leu Pro Pro Met Ile  Asp Phe Leu Leu Val  Gly Ile Phe 
    1295                 1300                 1305             


Pro Thr  Thr Val His Leu Gln  Gln His Met Arg Arg  His His Ser 
    1310                 1315                 1320             


Gly Thr  Asp Ala Leu Tyr Phe  Thr Gly Leu Glu Gly  Ala Phe Gly 
    1325                 1330                 1335             


Thr Val  Asn Pro Lys Tyr His  Pro Ser Arg Asn Asn  Thr Ile Ala 
    1340                 1345                 1350             


Asn Phe  Thr Phe Ser Ala Trp  Val Met Pro Asn Ala  Asn Thr Asn 
    1355                 1360                 1365             


Gly Phe  Ile Ile Ala Lys Asp  Asp Gly Asn Gly Ser  Ile Tyr Tyr 
    1370                 1375                 1380             


Gly Val  Lys Ile Gln Thr Asn  Glu Ser His Val Thr  Leu Ser Leu 
    1385                 1390                 1395             


His Tyr  Lys Thr Leu Gly Ser  Asn Ala Thr Tyr Ile  Ala Lys Thr 
    1400                 1405                 1410             


Thr Val  Met Lys Tyr Leu Glu  Glu Ser Val Trp Leu  His Leu Leu 
    1415                 1420                 1425             


Ile Ile  Leu Glu Asp Gly Ile  Ile Glu Phe Tyr Leu  Asp Gly Asn 
    1430                 1435                 1440             


Ala Met  Pro Arg Gly Ile Lys  Ser Leu Lys Gly Glu  Ala Ile Thr 
    1445                 1450                 1455             


Asp Gly  Pro Gly Ile Leu Arg  Ile Gly Ala Gly Ile  Asn Gly Asn 
    1460                 1465                 1470             


Asp Arg  Phe Thr Gly Leu Met  Gln Asp Val Arg Ser  Tyr Glu Arg 
    1475                 1480                 1485             


Lys Leu  Thr Leu Glu Glu Ile  Tyr Glu Leu His Ala  Met Pro Ala 
    1490                 1495                 1500             


Lys Ser  Asp Leu His Pro Ile  Ser Gly Tyr Leu Glu  Phe Arg Gln 
    1505                 1510                 1515             


Gly Glu  Thr Asn Lys Ser Phe  Ile Ile Ser Ala Arg  Asp Asp Asn 
    1520                 1525                 1530             


Asp Glu  Glu Gly Glu Glu Leu  Phe Ile Leu Lys Leu  Val Ser Val 
    1535                 1540                 1545             


Tyr Gly  Gly Ala Arg Ile Ser  Glu Glu Asn Thr Thr  Ala Arg Leu 
    1550                 1555                 1560             


Thr Ile  Gln Lys Ser Asp Asn  Ala Asn Gly Leu Phe  Gly Phe Thr 
    1565                 1570                 1575             


Gly Ala  Cys Ile Pro Glu Ile  Ala Glu Glu Gly Ser  Thr Ile Ser 
    1580                 1585                 1590             


Cys Val  Val Glu Arg Thr Arg  Gly Ala Leu Asp Tyr  Val His Val 
    1595                 1600                 1605             


Phe Tyr  Thr Ile Ser Gln Ile  Glu Thr Asp Gly Ile  Asn Tyr Leu 
    1610                 1615                 1620             


Val Asp  Asp Phe Ala Asn Ala  Ser Gly Thr Ile Thr  Phe Leu Pro 
    1625                 1630                 1635             


Trp Gln  Arg Ser Glu Val Leu  Asn Ile Tyr Val Leu  Asp Asp Asp 
    1640                 1645                 1650             


Ile Pro  Glu Leu Asn Glu Tyr  Phe Arg Val Thr Leu  Val Ser Ala 
    1655                 1660                 1665             


Ile Pro  Gly Asp Gly Lys Leu  Gly Ser Thr Pro Thr  Ser Gly Ala 
    1670                 1675                 1680             


Ser Ile  Asp Pro Glu Lys Glu  Thr Thr Asp Ile Thr  Ile Lys Ala 
    1685                 1690                 1695             


Ser Asp  His Pro Tyr Gly Leu  Leu Gln Phe Ser Thr  Gly Leu Pro 
    1700                 1705                 1710             


Pro Gln  Pro Lys Asp Ala Met  Thr Leu Pro Ala Ser  Ser Val Pro 
    1715                 1720                 1725             


His Ile  Thr Val Glu Glu Glu  Asp Gly Glu Ile Arg  Leu Leu Val 
    1730                 1735                 1740             


Ile Arg  Ala Gln Gly Leu Leu  Gly Arg Val Thr Ala  Glu Phe Arg 
    1745                 1750                 1755             


Thr Val  Ser Leu Thr Ala Phe  Ser Pro Glu Asp Tyr  Gln Asn Val 
    1760                 1765                 1770             


Ala Gly  Thr Leu Glu Phe Gln  Pro Gly Glu Arg Tyr  Lys Tyr Ile 
    1775                 1780                 1785             


Phe Ile  Asn Ile Thr Asp Asn  Ser Ile Pro Glu Leu  Glu Lys Ser 
    1790                 1795                 1800             


Phe Lys  Val Glu Leu Leu Asn  Leu Glu Gly Gly Val  Ala Glu Leu 
    1805                 1810                 1815             


Phe Arg  Val Asp Gly Ser Gly  Ser Gly Asp Gly Asp  Met Glu Phe 
    1820                 1825                 1830             


Phe Leu  Pro Thr Ile His Lys  Arg Ala Ser Leu Gly  Val Ala Ser 
    1835                 1840                 1845             


Gln Ile  Leu Val Thr Ile Ala  Ala Ser Asp His Ala  His Gly Val 
    1850                 1855                 1860             


Phe Glu  Phe Ser Pro Glu Ser  Leu Phe Val Ser Gly  Thr Glu Pro 
    1865                 1870                 1875             


Glu Asp  Gly Tyr Ser Thr Val  Thr Leu Asn Val Ile  Arg His His 
    1880                 1885                 1890             


Gly Thr  Leu Ser Pro Val Thr  Leu His Trp Asn Ile  Asp Ser Asp 
    1895                 1900                 1905             


Pro Asp  Gly Asp Leu Ala Phe  Thr Ser Gly Asn Ile  Thr Phe Glu 
    1910                 1915                 1920             


Ile Gly  Gln Thr Ser Ala Asn  Ile Thr Val Glu Ile  Leu Pro Asp 
    1925                 1930                 1935             


Glu Asp  Pro Glu Leu Asp Lys  Ala Phe Ser Val Ser  Val Leu Ser 
    1940                 1945                 1950             


Val Ser  Ser Gly Ser Leu Gly  Ala His Ile Asn Ala  Thr Leu Thr 
    1955                 1960                 1965             


Val Leu  Ala Ser Asp Asp Pro  Tyr Gly Ile Phe Ile  Phe Ser Glu 
    1970                 1975                 1980             


Lys Asn  Arg Pro Val Lys Val  Glu Glu Ala Thr Gln  Asn Ile Thr 
    1985                 1990                 1995             


Leu Ser  Ile Ile Arg Leu Lys  Gly Leu Met Gly Lys  Val Leu Val 
    2000                 2005                 2010             


Ser Tyr  Ala Thr Leu Asp Asp  Met Glu Lys Pro Pro  Tyr Phe Pro 
    2015                 2020                 2025             


Pro Asn  Leu Ala Arg Ala Thr  Gln Gly Arg Asp Tyr  Ile Pro Ala 
    2030                 2035                 2040             


Ser Gly  Phe Ala Leu Phe Gly  Ala Asn Gln Ser Glu  Ala Thr Ile 
    2045                 2050                 2055             


Ala Ile  Ser Ile Leu Asp Asp  Asp Glu Pro Glu Arg  Ser Glu Ser 
    2060                 2065                 2070             


Val Phe  Ile Glu Leu Leu Asn  Ser Thr Leu Val Ala  Lys Val Gln 
    2075                 2080                 2085             


Ser Arg  Ser Ile Pro Asn Ser  Pro Arg Leu Gly Pro  Lys Val Glu 
    2090                 2095                 2100             


Thr Ile  Ala Gln Leu Ile Ile  Ile Ala Asn Asp Asp  Ala Phe Gly 
    2105                 2110                 2115             


Thr Leu  Gln Leu Ser Ala Pro  Ile Val Arg Val Ala  Glu Asn His 
    2120                 2125                 2130             


Val Gly  Pro Ile Ile Asn Val  Thr Arg Thr Gly Gly  Ala Phe Ala 
    2135                 2140                 2145             


Asp Val  Ser Val Lys Phe Lys  Ala Val Pro Ile Thr  Ala Ile Ala 
    2150                 2155                 2160             


Gly Glu  Asp Tyr Ser Ile Ala  Ser Ser Asp Val Val  Leu Leu Glu 
    2165                 2170                 2175             


Gly Glu  Thr Ser Lys Ala Val  Pro Ile Tyr Val Ile  Asn Asp Ile 
    2180                 2185                 2190             


Tyr Pro  Glu Leu Glu Glu Ser  Phe Leu Val Gln Leu  Met Asn Glu 
    2195                 2200                 2205             


Thr Thr  Gly Gly Ala Arg Leu  Gly Ala Leu Thr Glu  Ala Val Ile 
    2210                 2215                 2220             


Ile Ile  Glu Ala Ser Asp Asp  Pro Tyr Gly Leu Phe  Gly Phe Gln 
    2225                 2230                 2235             


Ile Thr  Lys Leu Ile Val Glu  Glu Pro Glu Phe Asn  Ser Val Lys 
    2240                 2245                 2250             


Val Asn  Leu Pro Ile Ile Arg  Asn Ser Gly Thr Leu  Gly Asn Val 
    2255                 2260                 2265             


Thr Val  Gln Trp Val Ala Thr  Ile Asn Gly Gln Leu  Ala Thr Gly 
    2270                 2275                 2280             


Asp Leu  Arg Val Val Ser Gly  Asn Val Thr Phe Ala  Pro Gly Glu 
    2285                 2290                 2295             


Thr Ile  Gln Thr Leu Leu Leu  Glu Val Leu Ala Asp  Asp Val Pro 
    2300                 2305                 2310             


Glu Ile  Glu Glu Val Ile Gln  Val Gln Leu Thr Asp  Ala Ser Gly 
    2315                 2320                 2325             


Gly Gly  Thr Ile Gly Leu Asp  Arg Ile Ala Asn Ile  Ile Ile Pro 
    2330                 2335                 2340             


Ala Asn  Asp Asp Pro Tyr Gly  Thr Val Ala Phe Ala  Gln Met Val 
    2345                 2350                 2355             


Tyr Arg  Val Gln Glu Pro Leu  Glu Arg Ser Ser Cys  Ala Asn Ile 
    2360                 2365                 2370             


Thr Val  Arg Arg Ser Gly Gly  His Phe Gly Arg Leu  Leu Leu Phe 
    2375                 2380                 2385             


Tyr Ser  Thr Ser Asp Ile Asp  Val Val Ala Leu Ala  Met Glu Glu 
    2390                 2395                 2400             


Gly Gln  Asp Leu Leu Ser Tyr  Tyr Glu Ser Pro Ile  Gln Gly Val 
    2405                 2410                 2415             


Pro Asp  Pro Leu Trp Arg Thr  Trp Met Asn Val Ser  Ala Val Gly 
    2420                 2425                 2430             


Glu Pro  Leu Tyr Thr Cys Ala  Thr Leu Cys Leu Lys  Glu Gln Ala 
    2435                 2440                 2445             


Cys Ser  Ala Phe Ser Phe Phe  Ser Ala Ser Glu Gly  Pro Gln Cys 
    2450                 2455                 2460             


Phe Trp  Met Thr Ser Trp Ile  Ser Pro Ala Val Asn  Asn Ser Asp 
    2465                 2470                 2475             


Phe Trp  Thr Tyr Arg Lys Asn  Met Thr Arg Val Ala  Ser Leu Phe 
    2480                 2485                 2490             


Ser Gly  Gln Ala Val Ala Gly  Ser Asp Tyr Glu Pro  Val Thr Arg 
    2495                 2500                 2505             


Gln Trp  Ala Ile Met Gln Glu  Gly Asp Glu Phe Ala  Asn Leu Thr 
    2510                 2515                 2520             


Val Ser  Ile Leu Pro Asp Asp  Phe Pro Glu Met Asp  Glu Ser Phe 
    2525                 2530                 2535             


Leu Ile  Ser Leu Leu Glu Val  His Leu Met Asn Ile  Ser Ala Ser 
    2540                 2545                 2550             


Leu Lys  Asn Gln Pro Thr Ile  Gly Gln Pro Asn Ile  Ser Thr Val 
    2555                 2560                 2565             


Val Ile  Ala Leu Asn Gly Asp  Ala Phe Gly Val Phe  Val Ile Tyr 
    2570                 2575                 2580             


Asn Ile  Ser Pro Asn Thr Ser  Glu Asp Gly Leu Phe  Val Glu Val 
    2585                 2590                 2595             


Gln Glu  Gln Pro Gln Thr Leu  Val Glu Leu Met Ile  His Arg Thr 
    2600                 2605                 2610             


Gly Gly  Ser Leu Gly Gln Val  Ala Val Glu Trp Arg  Val Val Gly 
    2615                 2620                 2625             


Gly Thr  Ala Thr Glu Gly Leu  Asp Phe Ile Gly Ala  Gly Glu Ile 
    2630                 2635                 2640             


Leu Thr  Phe Ala Glu Gly Glu  Thr Lys Lys Thr Val  Ile Leu Thr 
    2645                 2650                 2655             


Ile Leu  Asp Asp Ser Glu Pro  Glu Asp Asp Glu Ser  Ile Ile Val 
    2660                 2665                 2670             


Ser Leu  Val Tyr Thr Glu Gly  Gly Ser Arg Ile Leu  Pro Ser Ser 
    2675                 2680                 2685             


Asp Thr  Val Arg Val Asn Ile  Leu Ala Asn Asp Asn  Val Ala Gly 
    2690                 2695                 2700             


Ile Val  Ser Phe Gln Thr Ala  Ser Arg Ser Val Ile  Gly His Glu 
    2705                 2710                 2715             


Gly Glu  Ile Leu Gln Phe His  Val Ile Arg Thr Phe  Pro Gly Arg 
    2720                 2725                 2730             


Gly Asn  Val Thr Val Asn Trp  Lys Ile Ile Gly Gln  Asn Leu Glu 
    2735                 2740                 2745             


Leu Asn  Phe Ala Asn Phe Ser  Gly Gln Leu Phe Phe  Pro Glu Gly 
    2750                 2755                 2760             


Ser Leu  Asn Thr Thr Leu Phe  Val His Leu Leu Asp  Asp Asn Ile 
    2765                 2770                 2775             


Pro Glu  Glu Lys Glu Val Tyr  Gln Val Ile Leu Tyr  Asp Val Arg 
    2780                 2785                 2790             


Thr Gln  Gly Val Pro Pro Ala  Gly Ile Ala Leu Leu  Asp Ala Gln 
    2795                 2800                 2805             


Gly Tyr  Ala Ala Val Leu Thr  Val Glu Ala Ser Asp  Glu Pro His 
    2810                 2815                 2820             


Gly Val  Leu Asn Phe Ala Leu  Ser Ser Arg Phe Val  Leu Leu Gln 
    2825                 2830                 2835             


Glu Ala  Asn Ile Thr Ile Gln  Leu Phe Ile Asn Arg  Glu Phe Gly 
    2840                 2845                 2850             


Ser Leu  Gly Ala Ile Asn Val  Thr Tyr Thr Thr Val  Pro Gly Met 
    2855                 2860                 2865             


Leu Ser  Leu Lys Asn Gln Thr  Val Gly Asn Leu Ala  Glu Pro Glu 
    2870                 2875                 2880             


Val Asp  Phe Val Pro Ile Ile  Gly Phe Leu Ile Leu  Glu Glu Gly 
    2885                 2890                 2895             


Glu Thr  Ala Ala Ala Ile Asn  Ile Thr Ile Leu Glu  Asp Asp Val 
    2900                 2905                 2910             


Pro Glu  Leu Glu Glu Tyr Phe  Leu Val Asn Leu Thr  Tyr Val Gly 
    2915                 2920                 2925             


Leu Thr  Met Ala Ala Ser Thr  Ser Phe Pro Pro Arg  Leu Asp Ser 
    2930                 2935                 2940             


Glu Gly  Leu Thr Ala Gln Val  Ile Ile Asp Ala Asn  Asp Gly Ala 
    2945                 2950                 2955             


Arg Gly  Val Ile Glu Trp Gln  Gln Ser Arg Phe Glu  Val Asn Glu 
    2960                 2965                 2970             


Thr His  Gly Ser Leu Thr Leu  Val Ala Gln Arg Ser  Arg Glu Pro 
    2975                 2980                 2985             


Leu Gly  His Val Ser Leu Phe  Val Tyr Ala Gln Asn  Leu Glu Ala 
    2990                 2995                 3000             


Gln Val  Gly Leu Asp Tyr Ile  Phe Thr Pro Met Ile  Leu His Phe 
    3005                 3010                 3015             


Ala Asp  Gly Glu Arg Tyr Lys  Asn Val Asn Ile Met  Ile Leu Asp 
    3020                 3025                 3030             


Asp Asp  Ile Pro Glu Gly Asp  Glu Lys Phe Gln Leu  Ile Leu Thr 
    3035                 3040                 3045             


Asn Pro  Ser Pro Gly Leu Glu  Leu Gly Lys Asn Thr  Ile Ala Leu 
    3050                 3055                 3060             


Ile Ile  Val Leu Ala Asn Asp  Asp Gly Pro Gly Val  Leu Ser Phe 
    3065                 3070                 3075             


Asn Asn  Ser Glu His Phe Phe  Leu Arg Glu Pro Thr  Ala Leu Tyr 
    3080                 3085                 3090             


Val Gln  Glu Ser Val Ala Val  Leu Tyr Ile Val Arg  Glu Pro Ala 
    3095                 3100                 3105             


Gln Gly  Leu Phe Gly Thr Val  Thr Val Gln Phe Ile  Val Thr Glu 
    3110                 3115                 3120             


Val Asn  Ser Ser Asn Glu Ser  Lys Asp Leu Thr Pro  Ser Lys Gly 
    3125                 3130                 3135             


Tyr Ile  Val Leu Glu Glu Gly  Val Arg Phe Lys Ala  Leu Gln Ile 
    3140                 3145                 3150             


Ser Ala  Ile Leu Asp Thr Glu  Pro Glu Met Asp Glu  Tyr Phe Val 
    3155                 3160                 3165             


Cys Thr  Leu Phe Asn Pro Thr  Gly Gly Ala Arg Leu  Gly Val His 
    3170                 3175                 3180             


Val Gln  Thr Leu Ile Thr Val  Leu Gln Asn Gln Ala  Pro Leu Gly 
    3185                 3190                 3195             


Leu Phe  Ser Ile Ser Ala Val  Glu Asn Arg Ala Thr  Ser Ile Asp 
    3200                 3205                 3210             


Ile Glu  Glu Ala Asn Arg Thr  Val Tyr Leu Asn Val  Ser Arg Thr 
    3215                 3220                 3225             


Asn Gly  Ile Asp Leu Ala Val  Ser Val Gln Trp Glu  Thr Val Ser 
    3230                 3235                 3240             


Glu Thr  Ala Phe Gly Met Arg  Gly Met Asp Val Val  Phe Ser Val 
    3245                 3250                 3255             


Phe Gln  Ser Phe Leu Asp Glu  Ser Ala Ser Gly Trp  Cys Phe Phe 
    3260                 3265                 3270             


Thr Leu  Glu Asn Leu Ile Tyr  Gly Ile Met Leu Arg  Lys Ser Ser 
    3275                 3280                 3285             


Val Thr  Val Tyr Arg Trp Gln  Gly Ile Phe Ile Pro  Val Glu Asp 
    3290                 3295                 3300             


Leu Asn  Ile Glu Asn Pro Lys  Thr Cys Glu Ala Phe  Asn Ile Gly 
    3305                 3310                 3315             


Phe Ser  Pro Tyr Phe Val Ile  Thr His Glu Glu Arg  Asn Glu Glu 
    3320                 3325                 3330             


Lys Pro  Ser Leu Asn Ser Val  Phe Thr Phe Thr Ser  Gly Phe Lys 
    3335                 3340                 3345             


Leu Phe  Leu Val Gln Thr Ile  Ile Ile Leu Glu Ser  Ser Gln Val 
    3350                 3355                 3360             


Arg Tyr  Phe Thr Ser Asp Ser  Gln Asp Tyr Leu Ile  Ile Ala Ser 
    3365                 3370                 3375             


Gln Arg  Asp Asp Ser Glu Leu  Thr Gln Val Phe Arg  Trp Asn Gly 
    3380                 3385                 3390             


Gly Ser  Phe Val Leu His Gln  Lys Leu Pro Val Arg  Gly Val Leu 
    3395                 3400                 3405             


Thr Val  Ala Leu Phe Asn Lys  Gly Gly Ser Val Phe  Leu Ala Ile 
    3410                 3415                 3420             


Ser Gln  Ala Asn Ala Arg Leu  Asn Ser Leu Leu Phe  Arg Trp Ser 
    3425                 3430                 3435             


Gly Ser  Gly Phe Ile Asn Phe  Gln Glu Val Pro Val  Ser Gly Thr 
    3440                 3445                 3450             


Thr Glu  Val Glu Ala Leu Ser  Ser Ala Asn Asp Ile  Tyr Leu Ile 
    3455                 3460                 3465             


Phe Ala  Glu Asn Val Phe Leu  Gly Asp Gln Asn Ser  Ile Asp Ile 
    3470                 3475                 3480             


Phe Ile  Trp Glu Met Gly Gln  Ser Ser Phe Arg Tyr  Phe Gln Ser 
    3485                 3490                 3495             


Val Asp  Phe Ala Ala Val Asn  Arg Ile His Ser Phe  Thr Pro Ala 
    3500                 3505                 3510             


Ser Gly  Ile Ala His Ile Leu  Leu Ile Gly Gln Asp  Met Ser Ala 
    3515                 3520                 3525             


Leu Tyr  Cys Trp Asn Ser Glu  Arg Asn Gln Phe Ser  Phe Val Leu 
    3530                 3535                 3540             


Glu Val  Pro Ser Ala Tyr Asp  Val Ala Ser Val Thr  Val Lys Ser 
    3545                 3550                 3555             


Leu Asn  Ser Ser Lys Asn Leu  Ile Ala Leu Val Gly  Ala His Ser 
    3560                 3565                 3570             


His Ile  Tyr Glu Leu Ala Tyr  Ile Ser Ser His Ser  Asp Phe Ile 
    3575                 3580                 3585             


Pro Ser  Ser Gly Glu Leu Ile  Phe Glu Pro Gly Glu  Arg Glu Ala 
    3590                 3595                 3600             


Thr Ile  Ala Val Asn Ile Leu  Asp Asp Thr Val Pro  Glu Lys Glu 
    3605                 3610                 3615             


Glu Ser  Phe Lys Val Gln Leu  Lys Asn Pro Lys Gly  Gly Ala Glu 
    3620                 3625                 3630             


Ile Gly  Ile Asn Asp Ser Val  Thr Ile Thr Ile Leu  Ser Asn Asp 
    3635                 3640                 3645             


Asp Ala  Tyr Gly Ile Val Ala  Phe Ala Gln Asn Ser  Leu Tyr Lys 
    3650                 3655                 3660             


Gln Val  Glu Glu Met Glu Gln  Asp Ser Leu Val Thr  Leu Asn Val 
    3665                 3670                 3675             


Glu Arg  Leu Lys Gly Thr Tyr  Gly Arg Ile Thr Ile  Ala Trp Glu 
    3680                 3685                 3690             


Ala Asp  Gly Ser Ile Ser Asp  Ile Phe Pro Thr Ser  Gly Val Ile 
    3695                 3700                 3705             


Leu Phe  Thr Glu Gly Gln Val  Leu Ser Thr Ile Thr  Leu Thr Ile 
    3710                 3715                 3720             


Leu Ala  Asp Asn Ile Pro Glu  Leu Ser Glu Val Val  Ile Val Thr 
    3725                 3730                 3735             


Leu Thr  Arg Ile Thr Thr Glu  Gly Val Glu Asp Ser  Tyr Lys Gly 
    3740                 3745                 3750             


Ala Thr  Ile Asp Gln Asp Arg  Ser Lys Ser Val Ile  Thr Thr Leu 
    3755                 3760                 3765             


Pro Asn  Asp Ser Pro Phe Gly  Leu Val Gly Trp Arg  Ala Ala Ser 
    3770                 3775                 3780             


Val Phe  Ile Arg Val Ala Glu  Pro Lys Glu Asn Thr  Thr Thr Leu 
    3785                 3790                 3795             


Gln Leu  Gln Ile Ala Arg Asp  Lys Gly Leu Leu Gly  Asp Ile Ala 
    3800                 3805                 3810             


Ile His  Leu Arg Ala Gln Pro  Asn Phe Leu Leu His  Val Asp Asn 
    3815                 3820                 3825             


Gln Ala  Thr Glu Asn Glu Asp  Tyr Val Leu Gln Glu  Thr Ile Ile 
    3830                 3835                 3840             


Ile Met  Lys Glu Asn Ile Lys  Glu Ala His Ala Glu  Val Ser Ile 
    3845                 3850                 3855             


Leu Pro  Asp Asp Leu Pro Glu  Leu Glu Glu Gly Phe  Ile Val Thr 
    3860                 3865                 3870             


Ile Thr  Glu Val Asn Leu Val  Asn Ser Asp Phe Ser  Thr Gly Gln 
    3875                 3880                 3885             


Pro Ser  Val Arg Arg Pro Gly  Met Glu Ile Ala Glu  Ile Met Ile 
    3890                 3895                 3900             


Glu Glu  Asn Asp Asp Pro Arg  Gly Ile Phe Met Phe  His Val Thr 
    3905                 3910                 3915             


Arg Gly  Ala Gly Glu Val Ile  Thr Ala Tyr Glu Val  Pro Pro Pro 
    3920                 3925                 3930             


Leu Asn  Val Leu Gln Val Pro  Val Val Arg Leu Ala  Gly Ser Phe 
    3935                 3940                 3945             


Gly Ala  Val Asn Val Tyr Trp  Lys Ala Ser Pro Asp  Ser Ala Gly 
    3950                 3955                 3960             


Leu Glu  Asp Phe Lys Pro Ser  His Gly Ile Leu Glu  Phe Ala Asp 
    3965                 3970                 3975             


Lys Gln  Val Thr Ala Met Ile  Glu Ile Thr Ile Ile  Asp Asp Ala 
    3980                 3985                 3990             


Glu Phe  Glu Leu Thr Glu Thr  Phe Asn Ile Ser Leu  Ile Ser Val 
    3995                 4000                 4005             


Ala Gly  Gly Gly Arg Leu Gly  Asp Asp Val Val Val  Thr Val Val 
    4010                 4015                 4020             


Ile Pro  Gln Asn Asp Ser Pro  Phe Gly Val Phe Gly  Phe Glu Glu 
    4025                 4030                 4035             


Lys Thr  Val Met Ile Asp Glu  Ser Leu Ser Ser Asp  Asp Pro Asp 
    4040                 4045                 4050             


Ser Tyr  Val Thr Leu Thr Val  Val Arg Ser Pro Gly  Gly Lys Gly 
    4055                 4060                 4065             


Thr Val  Arg Leu Glu Trp Thr  Ile Asp Glu Lys Ala  Lys His Asn 
    4070                 4075                 4080             


Leu Ser  Pro Leu Asn Gly Thr  Leu His Phe Asp Glu  Thr Glu Ser 
    4085                 4090                 4095             


Gln Lys  Thr Ile Val Leu His  Thr Leu Gln Asp Thr  Val Leu Glu 
    4100                 4105                 4110             


Glu Asp  Arg Arg Phe Thr Ile  Gln Leu Ile Ser Ile  Asp Glu Val 
    4115                 4120                 4125             


Glu Ile  Ser Pro Val Lys Gly  Ser Ala Ser Ile Ile  Ile Arg Gly 
    4130                 4135                 4140             


Asp Lys  Arg Ala Ser Gly Glu  Val Gly Ile Ala Pro  Ser Ser Arg 
    4145                 4150                 4155             


His Ile  Leu Ile Gly Glu Pro  Ser Ala Lys Tyr Asn  Gly Thr Ala 
    4160                 4165                 4170             


Ile Ile  Ser Leu Val Arg Gly  Pro Gly Ile Leu Gly  Glu Val Thr 
    4175                 4180                 4185             


Val Phe  Trp Arg Ile Phe Pro  Pro Ser Val Gly Glu  Phe Ala Glu 
    4190                 4195                 4200             


Thr Ser  Gly Lys Leu Thr Met  Arg Asp Glu Gln Ser  Ala Val Ile 
    4205                 4210                 4215             


Val Val  Ile Gln Ala Leu Asn  Asp Asp Ile Pro Glu  Glu Lys Ser 
    4220                 4225                 4230             


Phe Tyr  Glu Phe Gln Leu Thr  Ala Val Ser Glu Gly  Gly Val Leu 
    4235                 4240                 4245             


Ser Glu  Ser Ser Ser Thr Ala  Asn Ile Thr Val Val  Ala Ser Asp 
    4250                 4255                 4260             


Ser Pro  Tyr Gly Arg Phe Ala  Phe Ser His Glu Gln  Leu Arg Val 
    4265                 4270                 4275             


Ser Glu  Ala Gln Arg Val Asn  Ile Thr Ile Ile Arg  Ser Ser Gly 
    4280                 4285                 4290             


Asp Phe  Gly His Val Arg Leu  Trp Tyr Lys Thr Met  Ser Gly Thr 
    4295                 4300                 4305             


Ala Glu  Ala Gly Leu Asp Phe  Val Pro Ala Ala Gly  Glu Leu Leu 
    4310                 4315                 4320             


Phe Glu  Ala Gly Glu Met Arg  Lys Ser Leu His Val  Glu Ile Leu 
    4325                 4330                 4335             


Asp Asp  Asp Tyr Pro Glu Gly  Pro Glu Glu Phe Ser  Leu Thr Ile 
    4340                 4345                 4350             


Thr Lys  Val Glu Leu Gln Gly  Arg Gly Tyr Asp Phe  Thr Ile Gln 
    4355                 4360                 4365             


Glu Asn  Gly Leu Gln Ile Asp  Gln Pro Pro Glu Ile  Gly Asn Ile 
    4370                 4375                 4380             


Ser Ile  Val Arg Ile Ile Ile  Met Lys Asn Asp Asn  Ala Glu Gly 
    4385                 4390                 4395             


Ile Ile  Glu Phe Asp Pro Lys  Tyr Thr Ala Phe Glu  Val Glu Glu 
    4400                 4405                 4410             


Asp Val  Gly Leu Ile Met Ile  Pro Val Val Arg Leu  His Gly Thr 
    4415                 4420                 4425             


Tyr Gly  Tyr Val Thr Ala Asp  Phe Ile Ser Gln Ser  Ser Ser Ala 
    4430                 4435                 4440             


Ser Pro  Gly Gly Val Asp Tyr  Ile Leu His Gly Ser  Thr Val Thr 
    4445                 4450                 4455             


Phe Gln  His Gly Gln Asn Leu  Ser Phe Ile Asn Ile  Ser Ile Ile 
    4460                 4465                 4470             


Asp Asp  Asn Glu Ser Glu Phe  Glu Glu Pro Ile Glu  Ile Leu Leu 
    4475                 4480                 4485             


Thr Gly  Ala Thr Gly Gly Ala  Val Leu Gly Arg His  Leu Val Ser 
    4490                 4495                 4500             


Arg Ile  Ile Ile Ala Lys Ser  Asp Ser Pro Phe Gly  Val Ile Arg 
    4505                 4510                 4515             


Phe Leu  Asn Gln Ser Lys Ile  Ser Ile Ala Asn Pro  Asn Ser Thr 
    4520                 4525                 4530             


Met Ile  Leu Ser Leu Val Leu  Glu Arg Thr Gly Gly  Leu Leu Gly 
    4535                 4540                 4545             


Glu Ile  Gln Val Asn Trp Glu  Thr Val Gly Pro Asn  Ser Gln Glu 
    4550                 4555                 4560             


Ala Leu  Leu Pro Gln Asn Arg  Asp Ile Ala Asp Pro  Val Ser Gly 
    4565                 4570                 4575             


Leu Phe  Tyr Phe Gly Glu Gly  Glu Gly Gly Val Arg  Thr Ile Ile 
    4580                 4585                 4590             


Leu Thr  Ile Tyr Pro His Glu  Glu Ile Glu Val Glu  Glu Thr Phe 
    4595                 4600                 4605             


Ile Ile  Lys Leu His Leu Val  Lys Gly Glu Ala Lys  Leu Asp Ser 
    4610                 4615                 4620             


Arg Ala  Lys Asp Val Thr Leu  Thr Ile Gln Glu Phe  Gly Asp Pro 
    4625                 4630                 4635             


Asn Gly  Val Val Gln Phe Ala  Pro Glu Thr Leu Ser  Lys Lys Thr 
    4640                 4645                 4650             


Tyr Ser  Glu Pro Leu Ala Leu  Glu Gly Pro Leu Leu  Ile Thr Phe 
    4655                 4660                 4665             


Phe Val  Arg Arg Val Lys Gly  Thr Phe Gly Glu Ile  Met Val Tyr 
    4670                 4675                 4680             


Trp Glu  Leu Ser Ser Glu Phe  Asp Ile Thr Glu Asp  Phe Leu Ser 
    4685                 4690                 4695             


Thr Ser  Gly Phe Phe Thr Ile  Ala Asp Gly Glu Ser  Glu Ala Ser 
    4700                 4705                 4710             


Phe Asp  Val His Leu Leu Pro  Asp Glu Val Pro Glu  Ile Glu Glu 
    4715                 4720                 4725             


Asp Tyr  Val Ile Gln Leu Val  Ser Val Glu Gly Gly  Ala Glu Leu 
    4730                 4735                 4740             


Asp Leu  Glu Lys Ser Ile Thr  Trp Phe Ser Val Tyr  Ala Asn Asp 
    4745                 4750                 4755             


Asp Pro  His Gly Val Phe Ala  Leu Tyr Ser Asp Arg  Gln Ser Ile 
    4760                 4765                 4770             


Leu Ile  Gly Gln Asn Leu Ile  Arg Ser Ile Gln Ile  Asn Ile Thr 
    4775                 4780                 4785             


Arg Leu  Ala Gly Thr Phe Gly  Asp Val Ala Val Gly  Leu Arg Ile 
    4790                 4795                 4800             


Ser Ser  Asp His Lys Glu Gln  Pro Ile Val Thr Glu  Asn Ala Glu 
    4805                 4810                 4815             


Arg Gln  Leu Val Val Lys Asp  Gly Ala Thr Tyr Lys  Val Asp Val 
    4820                 4825                 4830             


Val Pro  Ile Lys Asn Gln Val  Phe Leu Ser Leu Gly  Ser Asn Phe 
    4835                 4840                 4845             


Thr Leu  Gln Leu Val Thr Val  Met Leu Val Gly Gly  Arg Phe Tyr 
    4850                 4855                 4860             


Gly Met  Pro Thr Ile Leu Gln  Glu Ala Lys Ser Ala  Val Leu Pro 
    4865                 4870                 4875             


Val Ser  Glu Lys Ala Ala Asn  Ser Gln Val Gly Phe  Glu Ser Thr 
    4880                 4885                 4890             


Ala Phe  Gln Leu Met Asn Ile  Thr Ala Gly Thr Ser  His Val Met 
    4895                 4900                 4905             


Ile Ser  Arg Arg Gly Thr Tyr  Gly Ala Leu Ser Val  Ala Trp Thr 
    4910                 4915                 4920             


Thr Gly  Tyr Ala Pro Gly Leu  Glu Ile Pro Glu Phe  Ile Val Val 
    4925                 4930                 4935             


Gly Asn  Met Thr Pro Thr Leu  Gly Ser Leu Ser Phe  Ser His Gly 
    4940                 4945                 4950             


Glu Gln  Arg Lys Gly Val Phe  Leu Trp Thr Phe Pro  Ser Pro Gly 
    4955                 4960                 4965             


Trp Pro  Glu Ala Phe Val Leu  His Leu Ser Gly Val  Gln Ser Ser 
    4970                 4975                 4980             


Ala Pro  Gly Gly Ala Gln Leu  Arg Ser Gly Phe Ile  Val Ala Glu 
    4985                 4990                 4995             


Ile Glu  Pro Met Gly Val Phe  Gln Phe Ser Thr Ser  Ser Arg Asn 
    5000                 5005                 5010             


Ile Ile  Val Ser Glu Asp Thr  Gln Met Ile Arg Leu  His Val Gln 
    5015                 5020                 5025             


Arg Leu  Phe Gly Phe His Ser  Asp Leu Ile Lys Val  Ser Tyr Gln 
    5030                 5035                 5040             


Thr Thr  Ala Gly Ser Ala Lys  Pro Leu Glu Asp Phe  Glu Pro Val 
    5045                 5050                 5055             


Gln Asn  Gly Glu Leu Phe Phe  Gln Lys Phe Gln Thr  Glu Val Asp 
    5060                 5065                 5070             


Phe Glu  Ile Thr Ile Ile Asn  Asp Gln Leu Ser Glu  Ile Glu Glu 
    5075                 5080                 5085             


Phe Phe  Tyr Ile Asn Leu Thr  Ser Val Glu Ile Arg  Gly Leu Gln 
    5090                 5095                 5100             


Lys Phe  Asp Val Asn Trp Ser  Pro Arg Leu Asn Leu  Asp Phe Ser 
    5105                 5110                 5115             


Val Ala  Val Ile Thr Ile Leu  Asp Asn Asp Asp Leu  Ala Gly Met 
    5120                 5125                 5130             


Asp Ile  Ser Phe Pro Glu Thr  Thr Val Ala Val Ala  Val Asp Thr 
    5135                 5140                 5145             


Thr Leu  Ile Pro Val Glu Thr  Glu Ser Thr Thr Tyr  Leu Ser Thr 
    5150                 5155                 5160             


Ser Lys  Thr Thr Thr Ile Leu  Gln Pro Thr Asn Val  Val Ala Ile 
    5165                 5170                 5175             


Val Thr  Glu Ala Thr Gly Val  Ser Ala Ile Pro Glu  Lys Leu Val 
    5180                 5185                 5190             


Thr Leu  His Gly Thr Pro Ala  Val Ser Glu Lys Pro  Asp Val Ala 
    5195                 5200                 5205             


Thr Val  Thr Ala Asn Val Ser  Ile His Gly Thr Phe  Ser Leu Gly 
    5210                 5215                 5220             


Pro Ser  Ile Val Tyr Ile Glu  Glu Glu Met Lys Asn  Gly Thr Phe 
    5225                 5230                 5235             


Asn Thr  Ala Glu Val Leu Ile  Arg Arg Thr Gly Gly  Phe Thr Gly 
    5240                 5245                 5250             


Asn Val  Ser Ile Thr Val Lys  Thr Phe Gly Glu Arg  Cys Ala Gln 
    5255                 5260                 5265             


Met Glu  Pro Asn Ala Leu Pro  Phe Arg Gly Ile Tyr  Gly Ile Ser 
    5270                 5275                 5280             


Asn Leu  Thr Trp Ala Val Glu  Glu Glu Asp Phe Glu  Glu Gln Thr 
    5285                 5290                 5295             


Leu Thr  Leu Ile Phe Leu Asp  Gly Glu Arg Glu Arg  Lys Val Ser 
    5300                 5305                 5310             


Val Gln  Ile Leu Asp Asp Asp  Glu Pro Glu Gly Gln  Glu Phe Phe 
    5315                 5320                 5325             


Tyr Val  Phe Leu Thr Asn Pro  Gln Gly Gly Ala Gln  Ile Val Glu 
    5330                 5335                 5340             


Glu Lys  Asp Asp Thr Gly Phe  Ala Ala Phe Ala Met  Val Ile Ile 
    5345                 5350                 5355             


Thr Gly  Ser Asp Leu His Asn  Gly Ile Ile Gly Phe  Ser Glu Glu 
    5360                 5365                 5370             


Ser Gln  Ser Gly Leu Glu Leu  Arg Glu Gly Ala Val  Met Arg Arg 
    5375                 5380                 5385             


Leu His  Leu Ile Val Thr Arg  Gln Pro Asn Arg Ala  Phe Glu Asp 
    5390                 5395                 5400             


Val Lys  Val Phe Trp Arg Val  Thr Leu Asn Lys Thr  Val Val Val 
    5405                 5410                 5415             


Leu Gln  Lys Asp Gly Val Asn  Leu Val Glu Glu Leu  Gln Ser Val 
    5420                 5425                 5430             


Ser Gly  Thr Thr Thr Cys Thr  Met Gly Gln Thr Lys  Cys Phe Ile 
    5435                 5440                 5445             


Ser Ile  Glu Leu Lys Pro Glu  Lys Val Pro Gln Val  Glu Val Tyr 
    5450                 5455                 5460             


Phe Phe  Val Glu Leu Tyr Glu  Ala Thr Ala Gly Ala  Ala Ile Asn 
    5465                 5470                 5475             


Asn Ser  Ala Arg Phe Ala Gln  Ile Lys Ile Leu Glu  Ser Asp Glu 
    5480                 5485                 5490             


Ser Gln  Ser Leu Val Tyr Phe  Ser Val Gly Ser Arg  Leu Ala Val 
    5495                 5500                 5505             


Ala His  Lys Lys Ala Thr Leu  Ile Ser Leu Gln Val  Ala Arg Asp 
    5510                 5515                 5520             


Ser Gly  Thr Gly Leu Met Met  Ser Val Asn Phe Ser  Thr Gln Glu 
    5525                 5530                 5535             


Leu Arg  Ser Ala Glu Thr Ile  Gly Arg Thr Ile Ile  Ser Pro Ala 
    5540                 5545                 5550             


Ile Ser  Gly Lys Asp Phe Val  Ile Thr Glu Gly Thr  Leu Val Phe 
    5555                 5560                 5565             


Glu Pro  Gly Gln Arg Ser Thr  Val Leu Asp Val Ile  Leu Thr Pro 
    5570                 5575                 5580             


Glu Thr  Gly Ser Leu Asn Ser  Phe Pro Lys Arg Phe  Gln Ile Val 
    5585                 5590                 5595             


Leu Phe  Asp Pro Lys Gly Gly  Ala Arg Ile Asp Lys  Val Tyr Gly 
    5600                 5605                 5610             


Thr Ala  Asn Ile Thr Leu Val  Ser Asp Ala Asp Ser  Gln Ala Ile 
    5615                 5620                 5625             


Trp Gly  Leu Ala Asp Gln Leu  His Gln Pro Val Asn  Asp Asp Ile 
    5630                 5635                 5640             


Leu Asn  Arg Val Leu His Thr  Ile Ser Met Lys Val  Ala Thr Glu 
    5645                 5650                 5655             


Asn Thr  Asp Glu Gln Leu Ser  Ala Met Met His Leu  Ile Glu Lys 
    5660                 5665                 5670             


Ile Thr  Thr Glu Gly Lys Ile  Gln Ala Phe Ser Val  Ala Ser Arg 
    5675                 5680                 5685             


Thr Leu  Phe Tyr Glu Ile Leu  Cys Ser Leu Ile Asn  Pro Lys Arg 
    5690                 5695                 5700             


Lys Asp  Thr Arg Gly Phe Ser  His Phe Ala Glu Val  Thr Glu Asn 
    5705                 5710                 5715             


Phe Ala  Phe Ser Leu Leu Thr  Asn Val Thr Cys Gly  Ser Pro Gly 
    5720                 5725                 5730             


Glu Lys  Ser Lys Thr Ile Leu  Asp Ser Cys Pro Tyr  Leu Ser Ile 
    5735                 5740                 5745             


Leu Ala  Leu His Trp Tyr Pro  Gln Gln Ile Asn Gly  His Lys Phe 
    5750                 5755                 5760             


Glu Gly  Lys Glu Gly Asp Tyr  Ile Arg Ile Pro Glu  Arg Leu Leu 
    5765                 5770                 5775             


Asp Val  Gln Asp Ala Glu Ile  Met Ala Gly Lys Ser  Thr Cys Lys 
    5780                 5785                 5790             


Leu Val  Gln Phe Thr Glu Tyr  Ser Ser Gln Gln Trp  Phe Ile Ser 
    5795                 5800                 5805             


Gly Asn  Asn Leu Pro Thr Leu  Lys Asn Lys Val Leu  Ser Leu Ser 
    5810                 5815                 5820             


Val Lys  Gly Gln Ser Ser Gln  Leu Leu Thr Asn Asp  Asn Glu Val 
    5825                 5830                 5835             


Leu Tyr  Arg Ile Tyr Ala Ala  Glu Pro Arg Ile Ile  Pro Gln Thr 
    5840                 5845                 5850             


Ser Leu  Cys Leu Leu Trp Asn  Gln Ala Ala Ala Ser  Trp Leu Ser 
    5855                 5860                 5865             


Asp Ser  Gln Phe Cys Lys Val  Val Glu Glu Thr Ala  Asp Tyr Val 
    5870                 5875                 5880             


Glu Cys  Ala Cys Ser His Met  Ser Val Tyr Ala Val  Tyr Ala Arg 
    5885                 5890                 5895             


Thr Asp  Asn Leu Ser Ser Tyr  Asn Glu Ala Phe Phe  Thr Ser Gly 
    5900                 5905                 5910             


Phe Ile  Cys Ile Ser Gly Leu  Cys Leu Ala Val Leu  Ser His Ile 
    5915                 5920                 5925             


Phe Cys  Ala Arg Tyr Ser Met  Phe Ala Ala Lys Leu  Leu Thr His 
    5930                 5935                 5940             


Met Met  Ala Ala Ser Leu Gly  Thr Gln Ile Leu Phe  Leu Ala Ser 
    5945                 5950                 5955             


Ala Tyr  Ala Ser Pro Gln Leu  Ala Glu Glu Ser Cys  Ser Ala Met 
    5960                 5965                 5970             


Ala Ala  Val Thr His Tyr Leu  Tyr Leu Cys Gln Phe  Ser Trp Met 
    5975                 5980                 5985             


Leu Ile  Gln Ser Val Asn Phe  Trp Tyr Val Leu Val  Met Asn Asp 
    5990                 5995                 6000             


Glu His  Thr Glu Arg Arg Tyr  Leu Leu Phe Phe Leu  Leu Ser Trp 
    6005                 6010                 6015             


Gly Leu  Pro Ala Phe Val Val  Ile Leu Leu Ile Val  Ile Leu Lys 
    6020                 6025                 6030             


Gly Ile  Tyr His Gln Ser Met  Ser Gln Ile Tyr Gly  Leu Ile His 
    6035                 6040                 6045             


Gly Asp  Leu Cys Phe Ile Pro  Asn Val Tyr Ala Ala  Leu Phe Thr 
    6050                 6055                 6060             


Ala Ala  Leu Val Pro Leu Thr  Cys Leu Val Val Val  Phe Val Val 
    6065                 6070                 6075             


Phe Ile  His Ala Tyr Gln Val  Lys Pro Gln Trp Lys  Ala Tyr Asp 
    6080                 6085                 6090             


Asp Val  Phe Arg Gly Arg Thr  Asn Ala Ala Glu Ile  Pro Leu Ile 
    6095                 6100                 6105             


Leu Tyr  Leu Phe Ala Leu Ile  Ser Val Thr Trp Leu  Trp Gly Gly 
    6110                 6115                 6120             


Leu His  Met Ala Tyr Arg His  Phe Trp Met Leu Val  Leu Phe Val 
    6125                 6130                 6135             


Ile Phe  Asn Ser Leu Gln Gly  Leu Tyr Val Phe Met  Val Tyr Phe 
    6140                 6145                 6150             


Ile Leu  His Asn Gln Met Cys  Cys Pro Met Lys Ala  Ser Tyr Thr 
    6155                 6160                 6165             


Val Glu  Met Asn Gly His Pro  Gly Pro Ser Thr Ala  Phe Phe Thr 
    6170                 6175                 6180             


Pro Gly  Ser Gly Met Pro Pro  Ala Gly Gly Glu Ile  Ser Lys Ser 
    6185                 6190                 6195             


Thr Gln  Asn Leu Ile Gly Ala  Met Glu Glu Val Pro  Pro Asp Trp 
    6200                 6205                 6210             


Glu Arg  Ala Ser Phe Gln Gln  Gly Ser Gln Ala Ser  Pro Asp Leu 
    6215                 6220                 6225             


Lys Pro  Ser Pro Gln Asn Gly  Ala Thr Phe Pro Ser  Ser Gly Gly 
    6230                 6235                 6240             


Tyr Gly  Gln Gly Ser Leu Ile  Ala Asp Glu Glu Ser  Gln Glu Phe 
    6245                 6250                 6255             


Asp Asp  Leu Ile Phe Ala Leu  Lys Thr Gly Ala Gly  Leu Ser Val 
    6260                 6265                 6270             


Ser Asp  Asn Glu Ser Gly Gln  Gly Ser Gln Glu Gly  Gly Thr Leu 
    6275                 6280                 6285             


Thr Asp  Ser Gln Ile Val Glu  Leu Arg Arg Ile Pro  Ile Ala Asp 
    6290                 6295                 6300             


Thr His  Leu 
    6305     


<210>  275
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH1A__Homo_sapiens__NP_000658

<400>  275

Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Leu Lys Lys Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Lys Met Val Ala Val Gly Ile Cys Gly 
        35                  40                  45              


Thr Asp Asp His Val Val Ser Gly Thr Met Val Thr Pro Leu Pro Val 
    50                  55                  60                  


Ile Leu Gly His Glu Ala Ala Gly Ile Val Glu Ser Val Gly Glu Gly 
65                  70                  75                  80  


Val Thr Thr Val Lys Pro Gly Asp Lys Val Ile Pro Leu Ala Ile Pro 
                85                  90                  95      


Gln Cys Gly Lys Cys Arg Ile Cys Lys Asn Pro Glu Ser Asn Tyr Cys 
            100                 105                 110         


Leu Lys Asn Asp Val Ser Asn Pro Gln Gly Thr Leu Gln Asp Gly Thr 
        115                 120                 125             


Ser Arg Phe Thr Cys Arg Arg Lys Pro Ile His His Phe Leu Gly Ile 
    130                 135                 140                 


Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Asn Ala Val Ala Lys 
145                 150                 155                 160 


Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 
                165                 170                 175     


Phe Ser Thr Gly Tyr Gly Ser Ala Val Asn Val Ala Lys Val Thr Pro 
            180                 185                 190         


Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Ala 
        195                 200                 205             


Ile Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Ala Val Asp 
    210                 215                 220                 


Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Leu Gly Ala Thr Glu 
225                 230                 235                 240 


Cys Ile Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Lys 
                245                 250                 255     


Glu Met Thr Asp Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 
            260                 265                 270         


Leu Asp Thr Met Met Ala Ser Leu Leu Cys Cys His Glu Ala Cys Gly 
        275                 280                 285             


Thr Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met 
    290                 295                 300                 


Asn Pro Met Leu Leu Leu Thr Gly Arg Thr Trp Lys Gly Ala Ile Leu 
305                 310                 315                 320 


Gly Gly Phe Lys Ser Lys Glu Cys Val Pro Lys Leu Val Ala Asp Phe 
                325                 330                 335     


Met Ala Lys Lys Phe Ser Leu Asp Ala Leu Ile Thr His Val Leu Pro 
            340                 345                 350         


Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu His Ser Gly Lys Ser 
        355                 360                 365             


Ile Arg Thr Ile Leu Met Phe 
    370                 375 


<210>  276
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH1B__Homo_sapiens__NP_000659

<400>  276

Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Val Lys Lys Pro Phe Ser Ile Glu Asp Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala Tyr Glu Val Arg Ile Lys Met Val Ala Val Gly Ile Cys His 
        35                  40                  45              


Thr Asp Asp His Val Val Ser Gly Asn Leu Val Thr Pro Leu Pro Val 
    50                  55                  60                  


Ile Leu Gly His Glu Ala Ala Gly Ile Val Glu Ser Val Gly Glu Gly 
65                  70                  75                  80  


Val Thr Thr Val Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro 
                85                  90                  95      


Gln Cys Gly Lys Cys Arg Val Cys Lys Asn Pro Glu Ser Asn Tyr Cys 
            100                 105                 110         


Leu Lys Asn Asp Leu Gly Asn Pro Arg Gly Thr Leu Gln Asp Gly Thr 
        115                 120                 125             


Arg Arg Phe Thr Cys Arg Gly Lys Pro Ile His His Phe Leu Gly Thr 
    130                 135                 140                 


Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Asn Ala Val Ala Lys 
145                 150                 155                 160 


Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 
                165                 170                 175     


Phe Ser Thr Gly Tyr Gly Ser Ala Val Asn Val Ala Lys Val Thr Pro 
            180                 185                 190         


Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Ala 
        195                 200                 205             


Val Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Ala Val Asp 
    210                 215                 220                 


Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Leu Gly Ala Thr Glu 
225                 230                 235                 240 


Cys Ile Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Lys 
                245                 250                 255     


Glu Met Thr Asp Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 
            260                 265                 270         


Leu Asp Thr Met Met Ala Ser Leu Leu Cys Cys His Glu Ala Cys Gly 
        275                 280                 285             


Thr Ser Val Ile Val Gly Val Pro Pro Ala Ser Gln Asn Leu Ser Ile 
    290                 295                 300                 


Asn Pro Met Leu Leu Leu Thr Gly Arg Thr Trp Lys Gly Ala Val Tyr 
305                 310                 315                 320 


Gly Gly Phe Lys Ser Lys Glu Gly Ile Pro Lys Leu Val Ala Asp Phe 
                325                 330                 335     


Met Ala Lys Lys Phe Ser Leu Asp Ala Leu Ile Thr His Val Leu Pro 
            340                 345                 350         


Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu His Ser Gly Lys Ser 
        355                 360                 365             


Ile Arg Thr Val Leu Thr Phe 
    370                 375 


<210>  277
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH4__Homo_sapiens__NP_000661

<400>  277

Met Gly Thr Lys Gly Lys Val Ile Lys Cys Lys Ala Ala Ile Ala Trp 
1               5                   10                  15      


Glu Ala Gly Lys Pro Leu Cys Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Gln Ile Ile Ala Thr Ser Leu Cys His 
        35                  40                  45              


Thr Asp Ala Thr Val Ile Asp Ser Lys Phe Glu Gly Leu Ala Phe Pro 
    50                  55                  60                  


Val Ile Val Gly His Glu Ala Ala Gly Ile Val Glu Ser Ile Gly Pro 
65                  70                  75                  80  


Gly Val Thr Asn Val Lys Pro Gly Asp Lys Val Ile Pro Leu Tyr Ala 
                85                  90                  95      


Pro Leu Cys Arg Lys Cys Lys Phe Cys Leu Ser Pro Leu Thr Asn Leu 
            100                 105                 110         


Cys Gly Lys Ile Ser Asn Leu Lys Ser Pro Ala Ser Asp Gln Gln Leu 
        115                 120                 125             


Met Glu Asp Lys Thr Ser Arg Phe Thr Cys Lys Gly Lys Pro Val Tyr 
    130                 135                 140                 


His Phe Phe Gly Thr Ser Thr Phe Ser Gln Tyr Thr Val Val Ser Asp 
145                 150                 155                 160 


Ile Asn Leu Ala Lys Ile Asp Asp Asp Ala Asn Leu Glu Arg Val Cys 
                165                 170                 175     


Leu Leu Gly Cys Gly Phe Ser Thr Gly Tyr Gly Ala Ala Ile Asn Asn 
            180                 185                 190         


Ala Lys Val Thr Pro Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly 
        195                 200                 205             


Val Gly Leu Ser Ala Val Met Gly Cys Lys Ala Ala Gly Ala Ser Arg 
    210                 215                 220                 


Ile Ile Gly Ile Asp Ile Asn Ser Glu Lys Phe Val Lys Ala Lys Ala 
225                 230                 235                 240 


Leu Gly Ala Thr Asp Cys Leu Asn Pro Arg Asp Leu His Lys Pro Ile 
                245                 250                 255     


Gln Glu Val Ile Ile Glu Leu Thr Lys Gly Gly Val Asp Phe Ala Leu 
            260                 265                 270         


Asp Cys Ala Gly Gly Ser Glu Thr Met Lys Ala Ala Leu Asp Cys Thr 
        275                 280                 285             


Thr Ala Gly Trp Gly Ser Cys Thr Phe Ile Gly Val Ala Ala Gly Ser 
    290                 295                 300                 


Lys Gly Leu Thr Ile Phe Pro Glu Glu Leu Ile Ile Gly Arg Thr Ile 
305                 310                 315                 320 


Asn Gly Thr Phe Phe Gly Gly Trp Lys Ser Val Asp Ser Ile Pro Lys 
                325                 330                 335     


Leu Val Thr Asp Tyr Lys Asn Lys Lys Phe Asn Leu Asp Ala Leu Val 
            340                 345                 350         


Thr His Thr Leu Pro Phe Asp Lys Ile Ser Glu Ala Phe Asp Leu Met 
        355                 360                 365             


Asn Gln Gly Lys Ser Val Arg Thr Ile Leu Ile Phe 
    370                 375                 380 


<210>  278
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH5__Homo_sapiens__NP_000662

<400>  278

Met Ala Asn Glu Val Ile Lys Cys Lys Ala Ala Val Ala Trp Glu Ala 
1               5                   10                  15      


Gly Lys Pro Leu Ser Ile Glu Glu Ile Glu Val Ala Pro Pro Lys Ala 
            20                  25                  30          


His Glu Val Arg Ile Lys Ile Ile Ala Thr Ala Val Cys His Thr Asp 
        35                  40                  45              


Ala Tyr Thr Leu Ser Gly Ala Asp Pro Glu Gly Cys Phe Pro Val Ile 
    50                  55                  60                  


Leu Gly His Glu Gly Ala Gly Ile Val Glu Ser Val Gly Glu Gly Val 
65                  70                  75                  80  


Thr Lys Leu Lys Ala Gly Asp Thr Val Ile Pro Leu Tyr Ile Pro Gln 
                85                  90                  95      


Cys Gly Glu Cys Lys Phe Cys Leu Asn Pro Lys Thr Asn Leu Cys Gln 
            100                 105                 110         


Lys Ile Arg Val Thr Gln Gly Lys Gly Leu Met Pro Asp Gly Thr Ser 
        115                 120                 125             


Arg Phe Thr Cys Lys Gly Lys Thr Ile Leu His Tyr Met Gly Thr Ser 
    130                 135                 140                 


Thr Phe Ser Glu Tyr Thr Val Val Ala Asp Ile Ser Val Ala Lys Ile 
145                 150                 155                 160 


Asp Pro Leu Ala Pro Leu Asp Lys Val Cys Leu Leu Gly Cys Gly Ile 
                165                 170                 175     


Ser Thr Gly Tyr Gly Ala Ala Val Asn Thr Ala Lys Leu Glu Pro Gly 
            180                 185                 190         


Ser Val Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ala Val Ile 
        195                 200                 205             


Met Gly Cys Lys Val Ala Gly Ala Ser Arg Ile Ile Gly Val Asp Ile 
    210                 215                 220                 


Asn Lys Asp Lys Phe Ala Arg Ala Lys Glu Phe Gly Ala Thr Glu Cys 
225                 230                 235                 240 


Ile Asn Pro Gln Asp Phe Ser Lys Pro Ile Gln Glu Val Leu Ile Glu 
                245                 250                 255     


Met Thr Asp Gly Gly Val Asp Tyr Ser Phe Glu Cys Ile Gly Asn Val 
            260                 265                 270         


Lys Val Met Arg Ala Ala Leu Glu Ala Cys His Lys Gly Trp Gly Val 
        275                 280                 285             


Ser Val Val Val Gly Val Ala Ala Ser Gly Glu Glu Ile Ala Thr Arg 
    290                 295                 300                 


Pro Phe Gln Leu Val Thr Gly Arg Thr Trp Lys Gly Thr Ala Phe Gly 
305                 310                 315                 320 


Gly Trp Lys Ser Val Glu Ser Val Pro Lys Leu Val Ser Glu Tyr Met 
                325                 330                 335     


Ser Lys Lys Ile Lys Val Asp Glu Phe Val Thr His Asn Leu Ser Phe 
            340                 345                 350         


Asp Glu Ile Asn Lys Ala Phe Glu Leu Met His Ser Gly Lys Ser Ile 
        355                 360                 365             


Arg Thr Val Val Lys Ile 
    370                 


<210>  279
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH6__Homo_sapiens__NP_000663

<400>  279

Met Ser Thr Thr Gly Gln Val Ile Arg Cys Lys Ala Ala Ile Leu Trp 
1               5                   10                  15      


Lys Pro Gly Ala Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala Lys Glu Val Arg Ile Lys Val Val Ala Thr Gly Leu Cys Gly 
        35                  40                  45              


Thr Glu Met Lys Val Leu Gly Ser Lys His Leu Asp Leu Leu Tyr Pro 
    50                  55                  60                  


Thr Ile Leu Gly His Glu Gly Ala Gly Ile Val Glu Ser Ile Gly Glu 
65                  70                  75                  80  


Gly Val Ser Thr Val Lys Pro Gly Asp Lys Val Ile Thr Leu Phe Leu 
                85                  90                  95      


Pro Gln Cys Gly Glu Cys Thr Ser Cys Leu Asn Ser Glu Gly Asn Phe 
            100                 105                 110         


Cys Ile Gln Phe Lys Gln Ser Lys Thr Gln Leu Met Ser Asp Gly Thr 
        115                 120                 125             


Ser Arg Phe Thr Cys Lys Gly Lys Ser Ile Tyr His Phe Gly Asn Thr 
    130                 135                 140                 


Ser Thr Phe Cys Glu Tyr Thr Val Ile Lys Glu Ile Ser Val Ala Lys 
145                 150                 155                 160 


Ile Asp Ala Val Ala Pro Leu Glu Lys Val Cys Leu Ile Ser Cys Gly 
                165                 170                 175     


Phe Ser Thr Gly Phe Gly Ala Ala Ile Asn Thr Ala Lys Val Thr Pro 
            180                 185                 190         


Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val 
        195                 200                 205             


Val Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Gly Val Asp 
    210                 215                 220                 


Val Asn Lys Glu Lys Phe Lys Lys Ala Gln Glu Leu Gly Ala Thr Glu 
225                 230                 235                 240 


Cys Leu Asn Pro Gln Asp Leu Lys Lys Pro Ile Gln Glu Val Leu Phe 
                245                 250                 255     


Asp Met Thr Asp Ala Gly Ile Asp Phe Cys Phe Glu Ala Ile Gly Asn 
            260                 265                 270         


Leu Asp Val Leu Ala Ala Ala Leu Ala Ser Cys Asn Glu Ser Tyr Gly 
        275                 280                 285             


Val Cys Val Val Val Gly Val Leu Pro Ala Ser Val Gln Leu Lys Ile 
    290                 295                 300                 


Ser Gly Gln Leu Phe Phe Ser Gly Arg Ser Leu Lys Gly Ser Val Phe 
305                 310                 315                 320 


Gly Gly Trp Lys Ser Arg Gln His Ile Pro Lys Leu Val Ala Asp Tyr 
                325                 330                 335     


Met Ala Glu Lys Leu Asn Leu Asp Pro Leu Ile Thr His Thr Leu Asn 
            340                 345                 350         


Leu Asp Lys Ile Asn Glu Ala Val Glu Leu Met Lys Thr Gly Lys Trp 
        355                 360                 365             


<210>  280
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADH7__Homo_sapiens__NP_000664

<400>  280

Met Phe Ala Glu Ile Gln Ile Gln Asp Lys Asp Arg Met Gly Thr Ala 
1               5                   10                  15      


Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp Glu Gln Lys Gln 
            20                  25                  30          


Pro Phe Ser Ile Glu Glu Ile Glu Val Ala Pro Pro Lys Thr Lys Glu 
        35                  40                  45              


Val Arg Ile Lys Ile Leu Ala Thr Gly Ile Cys Arg Thr Asp Asp His 
    50                  55                  60                  


Val Ile Lys Gly Thr Met Val Ser Lys Phe Pro Val Ile Val Gly His 
65                  70                  75                  80  


Glu Ala Thr Gly Ile Val Glu Ser Ile Gly Glu Gly Val Thr Thr Val 
                85                  90                  95      


Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Leu Pro Gln Cys Arg Glu 
            100                 105                 110         


Cys Asn Ala Cys Arg Asn Pro Asp Gly Asn Leu Cys Ile Arg Ser Asp 
        115                 120                 125             


Ile Thr Gly Arg Gly Val Leu Ala Asp Gly Thr Thr Arg Phe Thr Cys 
    130                 135                 140                 


Lys Gly Lys Pro Val His His Phe Met Asn Thr Ser Thr Phe Thr Glu 
145                 150                 155                 160 


Tyr Thr Val Val Asp Glu Ser Ser Val Ala Lys Ile Asp Asp Ala Ala 
                165                 170                 175     


Pro Pro Glu Lys Val Cys Leu Ile Gly Cys Gly Phe Ser Thr Gly Tyr 
            180                 185                 190         


Gly Ala Ala Val Lys Thr Gly Lys Val Lys Pro Gly Ser Thr Cys Val 
        195                 200                 205             


Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val Ile Met Gly Cys Lys 
    210                 215                 220                 


Ser Ala Gly Ala Ser Arg Ile Ile Gly Ile Asp Leu Asn Lys Asp Lys 
225                 230                 235                 240 


Phe Glu Lys Ala Met Ala Val Gly Ala Thr Glu Cys Ile Ser Pro Lys 
                245                 250                 255     


Asp Ser Thr Lys Pro Ile Ser Glu Val Leu Ser Glu Met Thr Gly Asn 
            260                 265                 270         


Asn Val Gly Tyr Thr Phe Glu Val Ile Gly His Leu Glu Thr Met Ile 
        275                 280                 285             


Asp Ala Leu Ala Ser Cys His Met Asn Tyr Gly Thr Ser Val Val Val 
    290                 295                 300                 


Gly Val Pro Pro Ser Ala Lys Met Leu Thr Tyr Asp Pro Met Leu Leu 
305                 310                 315                 320 


Phe Thr Gly Arg Thr Trp Lys Gly Cys Val Phe Gly Gly Leu Lys Ser 
                325                 330                 335     


Arg Asp Asp Val Pro Lys Leu Val Thr Glu Phe Leu Ala Lys Lys Phe 
            340                 345                 350         


Asp Leu Asp Gln Leu Ile Thr His Val Leu Pro Phe Lys Lys Ile Ser 
        355                 360                 365             


Glu Gly Phe Glu Leu Leu Asn Ser Gly Gln Ser Ile Arg Thr Val Leu 
    370                 375                 380                 


Thr Phe 
385     


<210>  281
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADHFE1__Homo_sapiens__NP_653251

<400>  281

Met Ala Ala Ala Ala Arg Ala Arg Val Ala Tyr Leu Leu Arg Gln Leu 
1               5                   10                  15      


Gln Arg Ala Ala Cys Gln Cys Pro Thr His Ser His Thr Tyr Ser Gln 
            20                  25                  30          


Ala Pro Gly Leu Ser Pro Ser Gly Lys Thr Thr Asp Tyr Ala Phe Glu 
        35                  40                  45              


Met Ala Val Ser Asn Ile Arg Tyr Gly Ala Ala Val Thr Lys Glu Val 
    50                  55                  60                  


Gly Met Asp Leu Lys Asn Met Gly Ala Lys Asn Val Cys Leu Met Thr 
65                  70                  75                  80  


Asp Lys Asn Leu Ser Lys Leu Pro Pro Val Gln Val Ala Met Asp Ser 
                85                  90                  95      


Leu Val Lys Asn Gly Ile Pro Phe Thr Val Tyr Asp Asn Val Arg Val 
            100                 105                 110         


Glu Pro Thr Asp Ser Ser Phe Met Glu Ala Ile Glu Phe Ala Gln Lys 
        115                 120                 125             


Gly Ala Phe Asp Ala Tyr Val Ala Val Gly Gly Gly Ser Thr Met Asp 
    130                 135                 140                 


Thr Cys Lys Ala Ala Asn Leu Tyr Ala Ser Ser Pro His Ser Asp Phe 
145                 150                 155                 160 


Leu Asp Tyr Val Ser Ala Pro Ile Gly Lys Gly Lys Pro Val Ser Val 
                165                 170                 175     


Pro Leu Lys Pro Leu Ile Ala Val Pro Thr Thr Ser Gly Thr Gly Ser 
            180                 185                 190         


Glu Thr Thr Gly Val Ala Ile Phe Asp Tyr Glu His Leu Lys Val Lys 
        195                 200                 205             


Ile Gly Ile Thr Ser Arg Ala Ile Lys Pro Thr Leu Gly Leu Ile Asp 
    210                 215                 220                 


Pro Leu His Thr Leu His Met Pro Ala Arg Val Val Ala Asn Ser Gly 
225                 230                 235                 240 


Phe Asp Val Leu Cys His Ala Leu Glu Ser Tyr Thr Thr Leu Pro Tyr 
                245                 250                 255     


His Leu Arg Ser Pro Cys Pro Ser Asn Pro Ile Thr Arg Pro Ala Tyr 
            260                 265                 270         


Gln Gly Ser Asn Pro Ile Ser Asp Ile Trp Ala Ile His Ala Leu Arg 
        275                 280                 285             


Ile Val Ala Lys Tyr Leu Lys Arg Ala Val Arg Asn Pro Asp Asp Leu 
    290                 295                 300                 


Glu Ala Arg Ser His Met His Leu Ala Ser Ala Phe Ala Gly Ile Gly 
305                 310                 315                 320 


Phe Gly Asn Ala Gly Val His Leu Cys His Gly Met Ser Tyr Pro Ile 
                325                 330                 335     


Ser Gly Leu Val Lys Met Tyr Lys Ala Lys Asp Tyr Asn Val Asp His 
            340                 345                 350         


Pro Leu Val Pro His Gly Leu Ser Val Val Leu Thr Ser Pro Ala Val 
        355                 360                 365             


Phe Thr Phe Thr Ala Gln Met Phe Pro Glu Arg His Leu Glu Met Ala 
    370                 375                 380                 


Glu Ile Leu Gly Ala Asp Thr Arg Thr Ala Arg Ile Gln Asp Ala Gly 
385                 390                 395                 400 


Leu Val Leu Ala Asp Thr Leu Arg Lys Phe Leu Phe Asp Leu Asp Val 
                405                 410                 415     


Asp Asp Gly Leu Ala Ala Val Gly Tyr Ser Lys Ala Asp Ile Pro Ala 
            420                 425                 430         


Leu Val Lys Gly Thr Leu Pro Gln Glu Arg Val Thr Lys Leu Ala Pro 
        435                 440                 445             


Cys Pro Gln Ser Glu Glu Asp Leu Ala Ala Leu Phe Glu Ala Ser Met 
    450                 455                 460                 


Lys Leu Tyr 
465         


<210>  282
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI1__Homo_sapiens__NP_060739

<400>  282

Met Val Gln Ala Trp Tyr Met Asp Asp Ala Pro Gly Asp Pro Arg Gln 
1               5                   10                  15      


Pro His Arg Pro Asp Pro Gly Arg Pro Val Gly Leu Glu Gln Leu Arg 
            20                  25                  30          


Arg Leu Gly Val Leu Tyr Trp Lys Leu Asp Ala Asp Lys Tyr Glu Asn 
        35                  40                  45              


Asp Pro Glu Leu Glu Lys Ile Arg Arg Glu Arg Asn Tyr Ser Trp Met 
    50                  55                  60                  


Asp Ile Ile Thr Ile Cys Lys Asp Lys Leu Pro Asn Tyr Glu Glu Lys 
65                  70                  75                  80  


Ile Lys Met Phe Tyr Glu Glu His Leu His Leu Asp Asp Glu Ile Arg 
                85                  90                  95      


Tyr Ile Leu Asp Gly Ser Gly Tyr Phe Asp Val Arg Asp Lys Glu Asp 
            100                 105                 110         


Gln Trp Ile Arg Ile Phe Met Glu Lys Gly Asp Met Val Thr Leu Pro 
        115                 120                 125             


Ala Gly Ile Tyr His Arg Phe Thr Val Asp Glu Lys Asn Tyr Thr Lys 
    130                 135                 140                 


Ala Met Arg Leu Phe Val Gly Glu Pro Val Trp Thr Ala Tyr Asn Arg 
145                 150                 155                 160 


Pro Ala Asp His Phe Glu Ala Arg Gly Gln Tyr Val Lys Phe Leu Ala 
                165                 170                 175     


Gln Thr Ala 
            


<210>  283
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADIG__Homo_sapiens__NP_001018092

<400>  283

Met Lys Tyr Pro Leu Met Pro Leu Val Asn Asp Leu Thr Phe Ser Phe 
1               5                   10                  15      


Leu Val Phe Trp Phe Cys Leu Pro Val Gly Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Ile Trp Leu Arg Phe Leu Leu Ser Gln Asp Ser Glu Glu Asn Asp Ser 
        35                  40                  45              


Ser Val Cys Leu Asp Trp Glu Pro Trp Ser Lys Gly Pro Ala Glu Phe 
    50                  55                  60                  


Cys Trp Lys Gly Thr Leu His Gly Gln Glu Lys Glu Arg Pro Cys Trp 
65                  70                  75                  80  


<210>  284
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADIPOQ__Homo_sapiens__NP_001171271

<400>  284

Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 
            20                  25                  30          


Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 
        35                  40                  45              


His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 
65                  70                  75                  80  


Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 
                85                  90                  95      


Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 
            100                 105                 110         


Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Ile Pro Asn Met 
        115                 120                 125             


Pro Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 
    130                 135                 140                 


Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 
145                 150                 155                 160 


Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 
                165                 170                 175     


Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn 
            180                 185                 190         


Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 
        195                 200                 205             


Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 
    210                 215                 220                 


Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


His Asp Thr Asn 
                


<210>  285
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADIPOR1__Homo_sapiens__NP_001277558

<400>  285

Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Thr Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Thr Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         


Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             


Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 


Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 


Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     


His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         


Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Thr Asp Asp Thr Leu Leu 
    370                 375 


<210>  286
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADIPOR2__Homo_sapiens__XP_006719081

<400>  286

Met Asn Glu Pro Thr Glu Asn Arg Leu Gly Cys Ser Arg Thr Pro Glu 
1               5                   10                  15      


Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Thr Arg Arg 
            20                  25                  30          


Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala 
        35                  40                  45              


Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr 
    50                  55                  60                  


Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro 
65                  70                  75                  80  


Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys 
                85                  90                  95      


Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro 
            100                 105                 110         


Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro 
        115                 120                 125             


Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr 
    130                 135                 140                 


Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe Leu 
145                 150                 155                 160 


Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala 
                165                 170                 175     


Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile 
            180                 185                 190         


Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser 
        195                 200                 205             


Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala 
    210                 215                 220                 


Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr 
225                 230                 235                 240 


Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu 
                245                 250                 255     


Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro 
            260                 265                 270         


Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser 
        275                 280                 285             


Gly Ile Ile Pro Thr Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys 
    290                 295                 300                 


Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu 
305                 310                 315                 320 


Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe 
                325                 330                 335     


Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His 
            340                 345                 350         


Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn 
        355                 360                 365             


Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp 
    370                 375                 380                 


Ala Leu 
385     


<210>  287
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADIRF__Homo_sapiens__NP_006820

<400>  287

Met Ala Ser Lys Gly Leu Gln Asp Leu Lys Gln Gln Val Glu Gly Thr 
1               5                   10                  15      


Ala Gln Glu Ala Val Ser Ala Ala Gly Ala Ala Ala Gln Gln Val Val 
            20                  25                  30          


Asp Gln Ala Thr Glu Ala Gly Gln Lys Ala Met Asp Gln Leu Ala Lys 
        35                  40                  45              


Thr Thr Gln Glu Thr Ile Asp Lys Thr Ala Asn Gln Ala Ser Asp Thr 
    50                  55                  60                  


Phe Ser Gly Ile Gly Lys Lys Phe Gly Leu Leu Lys 
65                  70                  75      


<210>  288
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADK__Homo_sapiens__NP_001114

<400>  288

Met Thr Ser Val Arg Glu Asn Ile Leu Phe Gly Met Gly Asn Pro Leu 
1               5                   10                  15      


Leu Asp Ile Ser Ala Val Val Asp Lys Asp Phe Leu Asp Lys Tyr Ser 
            20                  25                  30          


Leu Lys Pro Asn Asp Gln Ile Leu Ala Glu Asp Lys His Lys Glu Leu 
        35                  40                  45              


Phe Asp Glu Leu Val Lys Lys Phe Lys Val Glu Tyr His Ala Gly Gly 
    50                  55                  60                  


Ser Thr Gln Asn Ser Ile Lys Val Ala Gln Trp Met Ile Gln Gln Pro 
65                  70                  75                  80  


His Lys Ala Ala Thr Phe Phe Gly Cys Ile Gly Ile Asp Lys Phe Gly 
                85                  90                  95      


Glu Ile Leu Lys Arg Lys Ala Ala Glu Ala His Val Asp Ala His Tyr 
            100                 105                 110         


Tyr Glu Gln Asn Glu Gln Pro Thr Gly Thr Cys Ala Ala Cys Ile Thr 
        115                 120                 125             


Gly Asp Asn Arg Ser Leu Ile Ala Asn Leu Ala Ala Ala Asn Cys Tyr 
    130                 135                 140                 


Lys Lys Glu Lys His Leu Asp Leu Glu Lys Asn Trp Met Leu Val Glu 
145                 150                 155                 160 


Lys Ala Arg Val Cys Tyr Ile Ala Gly Phe Phe Leu Thr Val Ser Pro 
                165                 170                 175     


Glu Ser Val Leu Lys Val Ala His His Ala Ser Glu Asn Asn Arg Ile 
            180                 185                 190         


Phe Thr Leu Asn Leu Ser Ala Pro Phe Ile Ser Gln Phe Tyr Lys Glu 
        195                 200                 205             


Ser Leu Met Lys Val Met Pro Tyr Val Asp Ile Leu Phe Gly Asn Glu 
    210                 215                 220                 


Thr Glu Ala Ala Thr Phe Ala Arg Glu Gln Gly Phe Glu Thr Lys Asp 
225                 230                 235                 240 


Ile Lys Glu Ile Ala Lys Lys Thr Gln Ala Leu Pro Lys Met Asn Ser 
                245                 250                 255     


Lys Arg Gln Arg Ile Val Ile Phe Thr Gln Gly Arg Asp Asp Thr Ile 
            260                 265                 270         


Met Ala Thr Glu Ser Glu Val Thr Ala Phe Ala Val Leu Asp Gln Asp 
        275                 280                 285             


Gln Lys Glu Ile Ile Asp Thr Asn Gly Ala Gly Asp Ala Phe Val Gly 
    290                 295                 300                 


Gly Phe Leu Ser Gln Leu Val Ser Asp Lys Pro Leu Thr Glu Cys Ile 
305                 310                 315                 320 


Arg Ala Gly His Tyr Ala Ala Ser Ile Ile Ile Arg Arg Thr Gly Cys 
                325                 330                 335     


Thr Phe Pro Glu Lys Pro Asp Phe His 
            340                 345 


<210>  289
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADM2__Homo_sapiens__NP_001240774

<400>  289

Met Ala Arg Ile Pro Thr Ala Ala Leu Gly Cys Ile Ser Leu Leu Cys 
1               5                   10                  15      


Leu Gln Leu Pro Gly Ser Leu Ser Arg Ser Leu Gly Gly Asp Pro Arg 
            20                  25                  30          


Pro Val Lys Pro Arg Glu Pro Pro Ala Arg Ser Pro Ser Ser Ser Leu 
        35                  40                  45              


Gln Pro Arg His Pro Ala Pro Arg Pro Val Val Trp Lys Leu His Arg 
    50                  55                  60                  


Ala Leu Gln Ala Gln Arg Gly Ala Gly Leu Ala Pro Val Met Gly Gln 
65                  70                  75                  80  


Pro Leu Arg Asp Gly Gly Arg Gln His Ser Gly Pro Arg Arg His Ser 
                85                  90                  95      


Gly Pro Arg Arg Thr Gln Ala Gln Leu Leu Arg Val Gly Cys Val Leu 
            100                 105                 110         


Gly Thr Cys Gln Val Gln Asn Leu Ser His Arg Leu Trp Gln Leu Met 
        115                 120                 125             


Gly Pro Ala Gly Arg Gln Asp Ser Ala Pro Val Asp Pro Ser Ser Pro 
    130                 135                 140                 


His Ser Tyr Gly 
145             


<210>  290
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADM__Homo_sapiens__NP_001115

<400>  290

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  291
<211>  1102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADNP__Homo_sapiens__XP_011527049

<400>  291

Met Phe Gln Leu Pro Val Asn Asn Leu Gly Ser Leu Arg Lys Ala Arg 
1               5                   10                  15      


Lys Thr Val Lys Lys Ile Leu Ser Asp Ile Gly Leu Glu Tyr Cys Lys 
            20                  25                  30          


Glu His Ile Glu Asp Phe Lys Gln Phe Glu Pro Asn Asp Phe Tyr Leu 
        35                  40                  45              


Lys Asn Thr Thr Trp Glu Asp Val Gly Leu Trp Asp Pro Ser Leu Thr 
    50                  55                  60                  


Lys Asn Gln Asp Tyr Arg Thr Lys Pro Phe Cys Cys Ser Ala Cys Pro 
65                  70                  75                  80  


Phe Ser Ser Lys Phe Phe Ser Ala Tyr Lys Ser His Phe Arg Asn Val 
                85                  90                  95      


His Ser Glu Asp Phe Glu Asn Arg Ile Leu Leu Asn Cys Pro Tyr Cys 
            100                 105                 110         


Thr Phe Asn Ala Asp Lys Lys Thr Leu Glu Thr His Ile Lys Ile Phe 
        115                 120                 125             


His Ala Pro Asn Ala Ser Ala Pro Ser Ser Ser Leu Ser Thr Phe Lys 
    130                 135                 140                 


Asp Lys Asn Lys Asn Asp Gly Leu Lys Pro Lys Gln Ala Asp Ser Val 
145                 150                 155                 160 


Glu Gln Ala Val Tyr Tyr Cys Lys Lys Cys Thr Tyr Arg Asp Pro Leu 
                165                 170                 175     


Tyr Glu Ile Val Arg Lys His Ile Tyr Arg Glu His Phe Gln His Val 
            180                 185                 190         


Ala Ala Pro Tyr Ile Ala Lys Ala Gly Glu Lys Ser Leu Asn Gly Ala 
        195                 200                 205             


Val Pro Leu Gly Ser Asn Ala Arg Glu Glu Ser Ser Ile His Cys Lys 
    210                 215                 220                 


Arg Cys Leu Phe Met Pro Lys Ser Tyr Glu Ala Leu Val Gln His Val 
225                 230                 235                 240 


Ile Glu Asp His Glu Arg Ile Gly Tyr Gln Val Thr Ala Met Ile Gly 
                245                 250                 255     


His Thr Asn Val Val Val Pro Arg Ser Lys Pro Leu Met Leu Ile Ala 
            260                 265                 270         


Pro Lys Pro Gln Asp Lys Lys Ser Met Gly Leu Pro Pro Arg Ile Gly 
        275                 280                 285             


Ser Leu Ala Ser Gly Asn Val Arg Ser Leu Pro Ser Gln Gln Met Val 
    290                 295                 300                 


Asn Arg Leu Ser Ile Pro Lys Pro Asn Leu Asn Ser Thr Gly Val Asn 
305                 310                 315                 320 


Met Met Ser Ser Val His Leu Gln Gln Asn Asn Tyr Gly Val Lys Ser 
                325                 330                 335     


Val Gly Gln Gly Tyr Ser Val Gly Gln Ser Met Arg Leu Gly Leu Gly 
            340                 345                 350         


Gly Asn Ala Pro Val Ser Ile Pro Gln Gln Ser Gln Ser Val Lys Gln 
        355                 360                 365             


Leu Leu Pro Ser Gly Asn Gly Arg Ser Tyr Gly Leu Gly Ser Glu Gln 
    370                 375                 380                 


Arg Ser Gln Ala Pro Ala Arg Tyr Ser Leu Gln Ser Ala Asn Ala Ser 
385                 390                 395                 400 


Ser Leu Ser Ser Gly Gln Leu Lys Ser Pro Ser Leu Ser Gln Ser Gln 
                405                 410                 415     


Ala Ser Arg Val Leu Gly Gln Ser Ser Ser Lys Pro Ala Ala Ala Ala 
            420                 425                 430         


Thr Gly Pro Pro Pro Gly Asn Thr Ser Ser Thr Gln Lys Trp Lys Ile 
        435                 440                 445             


Cys Thr Ile Cys Asn Glu Leu Phe Pro Glu Asn Val Tyr Ser Val His 
    450                 455                 460                 


Phe Glu Lys Glu His Lys Ala Glu Lys Val Pro Ala Val Ala Asn Tyr 
465                 470                 475                 480 


Ile Met Lys Ile His Asn Phe Thr Ser Lys Cys Leu Tyr Cys Asn Arg 
                485                 490                 495     


Tyr Leu Pro Thr Asp Thr Leu Leu Asn His Met Leu Ile His Gly Leu 
            500                 505                 510         


Ser Cys Pro Tyr Cys Arg Ser Thr Phe Asn Asp Val Glu Lys Met Ala 
        515                 520                 525             


Ala His Met Arg Met Val His Ile Asp Glu Glu Met Gly Pro Lys Thr 
    530                 535                 540                 


Asp Ser Thr Leu Ser Phe Asp Leu Thr Leu Gln Gln Gly Ser His Thr 
545                 550                 555                 560 


Asn Ile His Leu Leu Val Thr Thr Tyr Asn Leu Arg Asp Ala Pro Ala 
                565                 570                 575     


Glu Ser Val Ala Tyr His Ala Gln Asn Asn Pro Pro Val Pro Pro Lys 
            580                 585                 590         


Pro Gln Pro Lys Val Gln Glu Lys Ala Asp Ile Pro Val Lys Ser Ser 
        595                 600                 605             


Pro Gln Ala Ala Val Pro Tyr Lys Lys Asp Val Gly Lys Thr Leu Cys 
    610                 615                 620                 


Pro Leu Cys Phe Ser Ile Leu Lys Gly Pro Ile Ser Asp Ala Leu Ala 
625                 630                 635                 640 


His His Leu Arg Glu Arg His Gln Val Ile Gln Thr Val His Pro Val 
                645                 650                 655     


Glu Lys Lys Leu Thr Tyr Lys Cys Ile His Cys Leu Gly Val Tyr Thr 
            660                 665                 670         


Ser Asn Met Thr Ala Ser Thr Ile Thr Leu His Leu Val His Cys Arg 
        675                 680                 685             


Gly Val Gly Lys Thr Gln Asn Gly Gln Asp Lys Thr Asn Ala Pro Ser 
    690                 695                 700                 


Arg Leu Asn Gln Ser Pro Ser Leu Ala Pro Val Lys Arg Thr Tyr Glu 
705                 710                 715                 720 


Gln Met Glu Phe Pro Leu Leu Lys Lys Arg Lys Leu Asp Asp Asp Ser 
                725                 730                 735     


Asp Ser Pro Ser Phe Phe Glu Glu Lys Pro Glu Glu Pro Val Val Leu 
            740                 745                 750         


Ala Leu Asp Pro Lys Gly His Glu Asp Asp Ser Tyr Glu Ala Arg Lys 
        755                 760                 765             


Ser Phe Leu Thr Lys Tyr Phe Asn Lys Gln Pro Tyr Pro Thr Arg Arg 
    770                 775                 780                 


Glu Ile Glu Lys Leu Ala Ala Ser Leu Trp Leu Trp Lys Ser Asp Ile 
785                 790                 795                 800 


Ala Ser His Phe Ser Asn Lys Arg Lys Lys Cys Val Arg Asp Cys Glu 
                805                 810                 815     


Lys Tyr Lys Pro Gly Val Leu Leu Gly Phe Asn Met Lys Glu Leu Asn 
            820                 825                 830         


Lys Val Lys His Glu Met Asp Phe Asp Ala Glu Trp Leu Phe Glu Asn 
        835                 840                 845             


His Asp Glu Lys Asp Ser Arg Val Asn Ala Ser Lys Thr Ala Asp Lys 
    850                 855                 860                 


Lys Leu Asn Leu Gly Lys Glu Asp Asp Ser Ser Ser Asp Ser Phe Glu 
865                 870                 875                 880 


Asn Leu Glu Glu Glu Ser Asn Glu Ser Gly Ser Pro Phe Asp Pro Val 
                885                 890                 895     


Phe Glu Val Glu Pro Lys Ile Ser Asn Asp Asn Pro Glu Glu His Val 
            900                 905                 910         


Leu Lys Val Ile Pro Glu Asp Ala Ser Glu Ser Glu Glu Lys Leu Asp 
        915                 920                 925             


Gln Lys Glu Asp Gly Ser Lys Tyr Glu Thr Ile His Leu Thr Glu Glu 
    930                 935                 940                 


Pro Thr Lys Leu Met His Asn Ala Ser Asp Ser Glu Val Asp Gln Asp 
945                 950                 955                 960 


Asp Val Val Glu Trp Lys Asp Gly Ala Ser Pro Ser Glu Ser Gly Pro 
                965                 970                 975     


Gly Ser Gln Gln Val Ser Asp Phe Glu Asp Asn Thr Cys Glu Met Lys 
            980                 985                 990         


Pro Gly Thr Trp Ser Asp Glu Ser  Ser Gln Ser Glu Asp  Ala Arg Ser 
        995                 1000                 1005             


Ser Lys  Pro Ala Ala Lys Lys  Lys Ala Thr Met Gln  Gly Asp Arg 
    1010                 1015                 1020             


Glu Gln  Leu Lys Trp Lys Asn  Ser Ser Tyr Gly Lys  Val Glu Gly 
    1025                 1030                 1035             


Phe Trp  Ser Lys Asp Gln Ser  Gln Trp Lys Asn Ala  Ser Glu Asn 
    1040                 1045                 1050             


Asp Glu  Arg Leu Ser Asn Pro  Gln Ile Glu Trp Gln  Asn Ser Thr 
    1055                 1060                 1065             


Ile Asp  Ser Glu Asp Gly Glu  Gln Phe Asp Asn Met  Thr Asp Gly 
    1070                 1075                 1080             


Val Ala  Glu Pro Met His Gly  Ser Leu Ala Gly Val  Lys Leu Ser 
    1085                 1090                 1095             


Ser Gln  Gln Ala 
    1100         


<210>  292
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADO__Homo_sapiens__NP_116193

<400>  292

Met Pro Arg Asp Asn Met Ala Ser Leu Ile Gln Arg Ile Ala Arg Gln 
1               5                   10                  15      


Ala Cys Leu Thr Phe Arg Gly Ser Gly Gly Gly Arg Gly Ala Ser Asp 
            20                  25                  30          


Arg Asp Ala Ala Ser Gly Pro Glu Ala Pro Met Gln Pro Gly Phe Pro 
        35                  40                  45              


Glu Asn Leu Ser Lys Leu Lys Ser Leu Leu Thr Gln Leu Arg Ala Glu 
    50                  55                  60                  


Asp Leu Asn Ile Ala Pro Arg Lys Ala Thr Leu Gln Pro Leu Pro Pro 
65                  70                  75                  80  


Asn Leu Pro Pro Val Thr Tyr Met His Ile Tyr Glu Thr Asp Gly Phe 
                85                  90                  95      


Ser Leu Gly Val Phe Leu Leu Lys Ser Gly Thr Ser Ile Pro Leu His 
            100                 105                 110         


Asp His Pro Gly Met His Gly Met Leu Lys Val Leu Tyr Gly Thr Val 
        115                 120                 125             


Arg Ile Ser Cys Met Asp Lys Leu Asp Ala Gly Gly Gly Gln Arg Pro 
    130                 135                 140                 


Arg Ala Leu Pro Pro Glu Gln Gln Phe Glu Pro Pro Leu Gln Pro Arg 
145                 150                 155                 160 


Glu Arg Glu Ala Val Arg Pro Gly Val Leu Arg Ser Arg Ala Glu Tyr 
                165                 170                 175     


Thr Glu Ala Ser Gly Pro Cys Ile Leu Thr Pro His Arg Asp Asn Leu 
            180                 185                 190         


His Gln Ile Asp Ala Val Glu Gly Pro Ala Ala Phe Leu Asp Ile Leu 
        195                 200                 205             


Ala Pro Pro Tyr Asp Pro Asp Asp Gly Arg Asp Cys His Tyr Tyr Arg 
    210                 215                 220                 


Val Leu Glu Pro Val Arg Pro Lys Glu Ala Ser Ser Ser Ala Cys Asp 
225                 230                 235                 240 


Leu Pro Arg Glu Val Trp Leu Leu Glu Thr Pro Gln Ala Asp Asp Phe 
                245                 250                 255     


Trp Cys Glu Gly Glu Pro Tyr Pro Gly Pro Lys Val Phe Pro 
            260                 265                 270 


<210>  293
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADORA1__Homo_sapiens__NP_000665

<400>  293

Met Pro Pro Ser Ile Ser Ala Phe Gln Ala Ala Tyr Ile Gly Ile Glu 
1               5                   10                  15      


Val Leu Ile Ala Leu Val Ser Val Pro Gly Asn Val Leu Val Ile Trp 
            20                  25                  30          


Ala Val Lys Val Asn Gln Ala Leu Arg Asp Ala Thr Phe Cys Phe Ile 
        35                  40                  45              


Val Ser Leu Ala Val Ala Asp Val Ala Val Gly Ala Leu Val Ile Pro 
    50                  55                  60                  


Leu Ala Ile Leu Ile Asn Ile Gly Pro Gln Thr Tyr Phe His Thr Cys 
65                  70                  75                  80  


Leu Met Val Ala Cys Pro Val Leu Ile Leu Thr Gln Ser Ser Ile Leu 
                85                  90                  95      


Ala Leu Leu Ala Ile Ala Val Asp Arg Tyr Leu Arg Val Lys Ile Pro 
            100                 105                 110         


Leu Arg Tyr Lys Met Val Val Thr Pro Arg Arg Ala Ala Val Ala Ile 
        115                 120                 125             


Ala Gly Cys Trp Ile Leu Ser Phe Val Val Gly Leu Thr Pro Met Phe 
    130                 135                 140                 


Gly Trp Asn Asn Leu Ser Ala Val Glu Arg Ala Trp Ala Ala Asn Gly 
145                 150                 155                 160 


Ser Met Gly Glu Pro Val Ile Lys Cys Glu Phe Glu Lys Val Ile Ser 
                165                 170                 175     


Met Glu Tyr Met Val Tyr Phe Asn Phe Phe Val Trp Val Leu Pro Pro 
            180                 185                 190         


Leu Leu Leu Met Val Leu Ile Tyr Leu Glu Val Phe Tyr Leu Ile Arg 
        195                 200                 205             


Lys Gln Leu Asn Lys Lys Val Ser Ala Ser Ser Gly Asp Pro Gln Lys 
    210                 215                 220                 


Tyr Tyr Gly Lys Glu Leu Lys Ile Ala Lys Ser Leu Ala Leu Ile Leu 
225                 230                 235                 240 


Phe Leu Phe Ala Leu Ser Trp Leu Pro Leu His Ile Leu Asn Cys Ile 
                245                 250                 255     


Thr Leu Phe Cys Pro Ser Cys His Lys Pro Ser Ile Leu Thr Tyr Ile 
            260                 265                 270         


Ala Ile Phe Leu Thr His Gly Asn Ser Ala Met Asn Pro Ile Val Tyr 
        275                 280                 285             


Ala Phe Arg Ile Gln Lys Phe Arg Val Thr Phe Leu Lys Ile Trp Asn 
    290                 295                 300                 


Asp His Phe Arg Cys Gln Pro Ala Pro Pro Ile Asp Glu Asp Leu Pro 
305                 310                 315                 320 


Glu Glu Arg Pro Asp Asp 
                325     


<210>  294
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADORA2A__Homo_sapiens__NP_001265429

<400>  294

Met Pro Ile Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Thr Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Thr Ile Ser Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Thr Gly Thr Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Thr 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
        355                 360                 365             


Gly Ser Ala Gln Glu Ser Gln Gly Asn Thr Gly Leu Pro Asp Val Glu 
    370                 375                 380                 


Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
385                 390                 395                 400 


Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser 
                405                 410         


<210>  295
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADORA2B__Homo_sapiens__NP_000667

<400>  295

Met Leu Leu Glu Thr Gln Asp Ala Leu Tyr Val Ala Leu Glu Leu Val 
1               5                   10                  15      


Ile Ala Ala Leu Ser Val Ala Gly Asn Val Leu Val Cys Ala Ala Val 
            20                  25                  30          


Gly Thr Ala Asn Thr Leu Gln Thr Pro Thr Asn Tyr Phe Leu Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Asp Val Ala Val Gly Leu Phe Ala Ile Pro Phe Ala 
    50                  55                  60                  


Ile Thr Ile Ser Leu Gly Phe Cys Thr Asp Phe Tyr Gly Cys Leu Phe 
65                  70                  75                  80  


Leu Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu 
                85                  90                  95      


Leu Ala Val Ala Val Asp Arg Tyr Leu Ala Ile Cys Val Pro Leu Arg 
            100                 105                 110         


Tyr Lys Ser Leu Val Thr Gly Thr Arg Ala Arg Gly Val Ile Ala Val 
        115                 120                 125             


Leu Trp Val Leu Ala Phe Gly Ile Gly Leu Thr Pro Phe Leu Gly Trp 
    130                 135                 140                 


Asn Ser Lys Asp Ser Ala Thr Asn Asn Cys Thr Glu Pro Trp Asp Gly 
145                 150                 155                 160 


Thr Thr Asn Glu Ser Cys Cys Leu Val Lys Cys Leu Phe Glu Asn Val 
                165                 170                 175     


Val Pro Met Ser Tyr Met Val Tyr Phe Asn Phe Phe Gly Cys Val Leu 
            180                 185                 190         


Pro Pro Leu Leu Ile Met Leu Val Ile Tyr Ile Lys Ile Phe Leu Val 
        195                 200                 205             


Ala Cys Arg Gln Leu Gln Arg Thr Glu Leu Met Asp His Ser Arg Thr 
    210                 215                 220                 


Thr Leu Gln Arg Glu Ile His Ala Ala Lys Ser Leu Ala Met Ile Val 
225                 230                 235                 240 


Gly Ile Phe Ala Leu Cys Trp Leu Pro Val His Ala Val Asn Cys Val 
                245                 250                 255     


Thr Leu Phe Gln Pro Ala Gln Gly Lys Asn Lys Pro Lys Trp Ala Met 
            260                 265                 270         


Asn Met Ala Ile Leu Leu Ser His Ala Asn Ser Val Val Asn Pro Ile 
        275                 280                 285             


Val Tyr Ala Tyr Arg Asn Arg Asp Phe Arg Tyr Thr Phe His Lys Ile 
    290                 295                 300                 


Ile Ser Arg Tyr Leu Leu Cys Gln Ala Asp Val Lys Ser Gly Asn Gly 
305                 310                 315                 320 


Gln Ala Gly Val Gln Pro Ala Leu Gly Val Gly Leu 
                325                 330         


<210>  296
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADPGK__Homo_sapiens__NP_112574

<400>  296

Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala 
1               5                   10                  15      


Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu 
            20                  25                  30          


Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro 
        35                  40                  45              


Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu 
    50                  55                  60                  


Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Val Asn 
65                  70                  75                  80  


Ala Cys Val Asp Val Val Leu Ser Gly Val Lys Leu Leu Gln Ala Leu 
                85                  90                  95      


Gly Leu Ser Pro Gly Asn Gly Lys Asp His Ser Ile Leu His Ser Arg 
            100                 105                 110         


Asn Asp Leu Glu Glu Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala 
        115                 120                 125             


Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln 
    130                 135                 140                 


Val Ala Ser Glu Phe Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala 
145                 150                 155                 160 


Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu 
                165                 170                 175     


Leu Cys Gly Pro Val Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn 
            180                 185                 190         


Val Phe Val Pro Pro Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu 
        195                 200                 205             


Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro 
    210                 215                 220                 


His Ala Asn Arg Phe Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met 
225                 230                 235                 240 


Asn Met Leu Glu Val Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp 
                245                 250                 255     


Leu Val Val Leu Ser Gly Leu His Met Met Glu Gly Gln Ser Lys Glu 
            260                 265                 270         


Leu Gln Arg Lys Arg Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile 
        275                 280                 285             


Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg 
    290                 295                 300                 


Glu Leu Met Ser Ser Ile Val His Gln Val Phe Pro Ala Val Thr Ser 
305                 310                 315                 320 


Leu Gly Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser 
                325                 330                 335     


Gly Pro His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly 
            340                 345                 350         


Met Val Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser 
        355                 360                 365             


Lys Ser Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val 
    370                 375                 380                 


Tyr His Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala 
385                 390                 395                 400 


Ala Val Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr 
                405                 410                 415     


Glu Thr Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe 
            420                 425                 430         


Met Thr Ser His Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn 
        435                 440                 445             


Lys Pro Val Val Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr 
    450                 455                 460                 


Pro Val Leu Val Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp 
465                 470                 475                 480 


Ala Ile Ser Ala Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr 
                485                 490                 495     


<210>  297
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADPRH__Homo_sapiens__NP_001278878

<400>  297

Met Glu Lys Tyr Val Ala Ala Met Val Leu Ser Ala Ala Gly Asp Ala 
1               5                   10                  15      


Leu Gly Tyr Tyr Asn Gly Lys Trp Glu Phe Leu Gln Asp Gly Glu Lys 
            20                  25                  30          


Ile His Arg Gln Leu Ala Gln Leu Gly Gly Leu Asp Ala Leu Asp Val 
        35                  40                  45              


Gly Arg Trp Arg Val Ser Asp Asp Thr Val Met His Leu Ala Thr Ala 
    50                  55                  60                  


Glu Ala Leu Val Glu Ala Gly Lys Ala Pro Lys Leu Thr Gln Leu Tyr 
65                  70                  75                  80  


Tyr Leu Leu Ala Lys His Tyr Gln Asp Cys Met Glu Asp Met Asp Gly 
                85                  90                  95      


Arg Ala Pro Gly Gly Ala Ser Val His Asn Ala Met Gln Leu Lys Pro 
            100                 105                 110         


Gly Lys Pro Asn Gly Trp Arg Ile Pro Phe Asn Ser His Glu Gly Gly 
        115                 120                 125             


Cys Gly Ala Ala Met Arg Ala Met Cys Ile Gly Leu Arg Phe Pro His 
    130                 135                 140                 


His Ser Gln Leu Asp Thr Leu Ile Gln Val Ser Ile Glu Ser Gly Arg 
145                 150                 155                 160 


Met Thr His His His Pro Thr Gly Tyr Leu Gly Ala Leu Ala Ser Ala 
                165                 170                 175     


Leu Phe Thr Ala Tyr Ala Val Asn Ser Arg Pro Pro Leu Gln Trp Gly 
            180                 185                 190         


Lys Gly Leu Met Glu Leu Leu Pro Glu Ala Lys Lys Tyr Ile Val Gln 
        195                 200                 205             


Ser Gly Tyr Phe Val Glu Glu Asn Leu Gln His Trp Ser Tyr Phe Gln 
    210                 215                 220                 


Thr Lys Trp Glu Asn Tyr Leu Lys Leu Arg Gly Ile Leu Asp Gly Glu 
225                 230                 235                 240 


Ser Ala Pro Thr Phe Pro Glu Ser Phe Gly Val Lys Glu Arg Asp Gln 
                245                 250                 255     


Phe Tyr Thr Ser Leu Ser Tyr Ser Gly Trp Gly Gly Ser Ser Gly His 
            260                 265                 270         


Asp Ala Pro Met Ile Ala Tyr Asp Ala Val Leu Ala Ala Gly Asp Ser 
        275                 280                 285             


Trp Lys Glu Leu Ala His Arg Ala Phe Phe His Gly Gly Asp Ser Asp 
    290                 295                 300                 


Ser Thr Ala Ala Ile Ala Gly Cys Trp Trp Gly Val Met Tyr Gly Phe 
305                 310                 315                 320 


Lys Gly Val Ser Pro Ser Asn Tyr Glu Lys Leu Glu Tyr Arg Asn Arg 
                325                 330                 335     


Leu Glu Glu Thr Ala Arg Ala Leu Tyr Ser Leu Gly Ser Lys Glu Asp 
            340                 345                 350         


Thr Val Ile Ser Leu 
        355         


<210>  298
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADPRHL1__Homo_sapiens__NP_612439

<400>  298

Met Glu Lys Phe Lys Ala Ala Met Leu Leu Gly Ser Val Gly Asp Ala 
1               5                   10                  15      


Leu Gly Tyr Arg Asn Val Cys Lys Glu Asn Ser Thr Val Gly Met Lys 
            20                  25                  30          


Ile Gln Glu Glu Leu Gln Arg Ser Gly Gly Leu Asp His Leu Val Leu 
        35                  40                  45              


Ser Pro Gly Glu Trp Pro Val Ser Asp Asn Thr Ile Met His Ile Ala 
    50                  55                  60                  


Thr Ala Glu Ala Leu Thr Thr Asp Tyr Trp Cys Leu Asp Asp Leu Tyr 
65                  70                  75                  80  


Arg Glu Met Val Arg Cys Tyr Val Glu Ile Val Glu Lys Leu Pro Glu 
                85                  90                  95      


Arg Arg Pro Asp Pro Ala Thr Ile Glu Gly Cys Ala Gln Leu Lys Pro 
            100                 105                 110         


Asn Asn Tyr Leu Leu Ala Trp His Thr Pro Phe Asn Glu Lys Gly Ser 
        115                 120                 125             


Gly Phe Gly Ala Ala Thr Lys Ala Met Cys Ile Gly Leu Arg Tyr Trp 
    130                 135                 140                 


Lys Pro Glu Arg Leu Glu Thr Leu Ile Glu Val Ser Val Glu Cys Gly 
145                 150                 155                 160 


Arg Met Thr His Asn His Pro Thr Gly Phe Leu Gly Ser Leu Cys Thr 
                165                 170                 175     


Ala Leu Phe Val Ser Phe Ala Ala Gln Gly Lys Pro Leu Val Gln Trp 
            180                 185                 190         


Gly Arg Asp Met Leu Arg Ala Val Pro Leu Ala Glu Glu Tyr Cys Arg 
        195                 200                 205             


Lys Thr Ile Arg His Thr Ala Glu Tyr Gln Glu His Trp Phe Tyr Phe 
    210                 215                 220                 


Glu Ala Lys Trp Gln Phe Tyr Leu Glu Glu Arg Lys Ile Ser Lys Asp 
225                 230                 235                 240 


Ser Glu Asn Lys Ala Ile Phe Pro Asp Asn Tyr Asp Ala Glu Glu Arg 
                245                 250                 255     


Glu Lys Thr Tyr Arg Lys Trp Ser Ser Glu Gly Arg Gly Gly Arg Arg 
            260                 265                 270         


Gly His Asp Ala Pro Met Ile Ala Tyr Asp Ala Leu Leu Ala Ala Gly 
        275                 280                 285             


Asn Ser Trp Thr Glu Leu Cys His Arg Ala Met Phe His Gly Gly Glu 
    290                 295                 300                 


Ser Ala Ala Thr Gly Thr Ile Ala Gly Cys Leu Phe Gly Leu Leu Tyr 
305                 310                 315                 320 


Gly Leu Asp Leu Val Pro Lys Gly Leu Tyr Gln Asp Leu Glu Asp Lys 
                325                 330                 335     


Glu Lys Leu Glu Asp Leu Gly Ala Ala Leu Tyr Arg Leu Ser Thr Glu 
            340                 345                 350         


Glu Lys 
        


<210>  299
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADPRHL2__Homo_sapiens__XP_011539938

<400>  299

Met Arg Val Ala Gly Ile Ser Leu Ala Tyr Ser Ser Val Gln Asp Val 
1               5                   10                  15      


Gln Lys Phe Ala Arg Leu Ser Ala Gln Leu Thr His Ala Ser Ser Leu 
            20                  25                  30          


Gly Tyr Asn Gly Ala Ile Leu Gln Ala Leu Ala Val His Leu Ala Leu 
        35                  40                  45              


Gln Gly Glu Ser Ser Ser Glu His Phe Leu Lys Gln Leu Leu Gly His 
    50                  55                  60                  


Met Glu Asp Leu Glu Gly Asp Ala Gln Ser Val Leu Asp Ala Arg Glu 
65                  70                  75                  80  


Leu Gly Met Glu Glu Arg Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly 
                85                  90                  95      


Glu Leu Leu Asp Gln Ala Ser Val Thr Arg Glu Glu Val Val Ser Glu 
            100                 105                 110         


Leu Gly Asn Gly Ile Ala Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr 
        115                 120                 125             


Cys Phe Leu Arg Cys Met Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe 
    130                 135                 140                 


Asn Ser Leu Gln Arg Thr Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp 
145                 150                 155                 160 


Thr Asp Thr Ile Ala Thr Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr 
                165                 170                 175     


Gly Met Asp Gln Val Pro Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr 
            180                 185                 190         


Glu Glu Thr Asp Ile Leu Ala Gln Ser Leu His Arg Val Phe Gln Lys 
        195                 200                 205             


Ser 
    


<210>  300
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRA1A__Homo_sapiens__NP_000671

<400>  300

Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Thr Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Thr His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Thr Ser Thr Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Thr Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Thr Ile Val Thr Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Thr Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Thr 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Thr Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Thr Lys Thr His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Thr Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Thr Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Thr Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Thr 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Thr Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Thr Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Thr Thr Ala Arg Val Arg Ser Lys Ser Phe Leu Gln Val 
            420                 425                 430         


Cys Cys Cys Val Gly Pro Ser Thr Pro Ser Leu Asp Lys Asn His Gln 
        435                 440                 445             


Val Pro Thr Ile Lys Val His Thr Ile Ser Leu Ser Glu Asn Gly Glu 
    450                 455                 460                 


Glu Val 
465     


<210>  301
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRA1B__Homo_sapiens__NP_000670

<400>  301

Met Asn Pro Asp Leu Asp Thr Gly His Asn Thr Ser Ala Pro Ala His 
1               5                   10                  15      


Trp Gly Glu Leu Lys Asn Ala Asn Phe Thr Gly Pro Asn Gln Thr Ser 
            20                  25                  30          


Ser Asn Ser Thr Leu Pro Gln Leu Asp Ile Thr Arg Ala Ile Ser Val 
        35                  40                  45              


Gly Leu Val Leu Gly Ala Phe Ile Leu Phe Ala Ile Val Gly Asn Ile 
    50                  55                  60                  


Leu Val Ile Leu Ser Val Ala Cys Asn Arg His Leu Arg Thr Pro Thr 
65                  70                  75                  80  


Asn Tyr Phe Ile Val Asn Leu Ala Met Ala Asp Leu Leu Leu Ser Phe 
                85                  90                  95      


Thr Val Leu Pro Phe Ser Ala Ala Leu Glu Val Leu Gly Tyr Trp Val 
            100                 105                 110         


Leu Gly Arg Ile Phe Cys Asp Ile Trp Ala Ala Val Asp Val Leu Cys 
        115                 120                 125             


Cys Thr Ala Ser Ile Leu Ser Leu Cys Ala Ile Ser Ile Asp Arg Tyr 
    130                 135                 140                 


Ile Gly Val Arg Tyr Ser Leu Gln Tyr Pro Thr Leu Val Thr Arg Arg 
145                 150                 155                 160 


Lys Ala Ile Leu Ala Leu Leu Ser Val Trp Val Leu Ser Thr Val Ile 
                165                 170                 175     


Ser Ile Gly Pro Leu Leu Gly Trp Lys Glu Pro Ala Pro Asn Asp Asp 
            180                 185                 190         


Lys Glu Cys Gly Val Thr Glu Glu Pro Phe Tyr Ala Leu Phe Ser Ser 
        195                 200                 205             


Leu Gly Ser Phe Tyr Ile Pro Leu Ala Val Ile Leu Val Met Tyr Cys 
    210                 215                 220                 


Arg Val Tyr Ile Val Ala Lys Arg Thr Thr Lys Asn Leu Glu Ala Gly 
225                 230                 235                 240 


Val Met Lys Glu Met Ser Asn Ser Lys Glu Leu Thr Leu Arg Ile His 
                245                 250                 255     


Ser Lys Asn Phe His Glu Asp Thr Leu Ser Ser Thr Lys Ala Lys Gly 
            260                 265                 270         


His Asn Pro Arg Ser Ser Ile Ala Val Lys Leu Phe Lys Phe Ser Arg 
        275                 280                 285             


Glu Lys Lys Ala Ala Lys Thr Leu Gly Ile Val Val Gly Met Phe Ile 
    290                 295                 300                 


Leu Cys Trp Leu Pro Phe Phe Ile Ala Leu Pro Leu Gly Ser Leu Phe 
305                 310                 315                 320 


Ser Thr Leu Lys Pro Pro Asp Ala Val Phe Lys Val Val Phe Trp Leu 
                325                 330                 335     


Gly Tyr Phe Asn Ser Cys Leu Asn Pro Ile Ile Tyr Pro Cys Ser Ser 
            340                 345                 350         


Lys Glu Phe Lys Arg Ala Phe Val Arg Ile Leu Gly Cys Gln Cys Arg 
        355                 360                 365             


Gly Arg Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Leu Gly Gly Cys 
    370                 375                 380                 


Ala Tyr Thr Tyr Arg Pro Trp Thr Arg Gly Gly Ser Leu Glu Arg Ser 
385                 390                 395                 400 


Gln Ser Arg Lys Asp Ser Leu Asp Asp Ser Gly Ser Cys Leu Ser Gly 
                405                 410                 415     


Ser Gln Arg Thr Leu Pro Ser Ala Ser Pro Ser Pro Gly Tyr Leu Gly 
            420                 425                 430         


Arg Gly Ala Pro Pro Pro Val Glu Leu Cys Ala Phe Pro Glu Trp Lys 
        435                 440                 445             


Ala Pro Gly Ala Leu Leu Ser Leu Pro Ala Pro Glu Pro Pro Gly Arg 
    450                 455                 460                 


Arg Gly Arg His Asp Ser Gly Pro Leu Phe Thr Phe Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Pro Glu Ser Pro Gly Thr Asp Gly Gly Ala Ser Asn Gly Gly Cys 
                485                 490                 495     


Glu Ala Ala Ala Asp Val Ala Asn Gly Gln Pro Gly Phe Lys Ser Asn 
            500                 505                 510         


Met Pro Leu Ala Pro Gly Gln Phe 
        515                 520 


<210>  302
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRA1D__Homo_sapiens__NP_000669

<400>  302

Met Thr Phe Arg Asp Leu Leu Ser Val Ser Phe Glu Gly Pro Arg Pro 
1               5                   10                  15      


Asp Ser Ser Ala Gly Gly Ser Ser Ala Gly Gly Gly Gly Gly Ser Ala 
            20                  25                  30          


Gly Gly Ala Ala Pro Ser Glu Gly Pro Ala Val Gly Gly Val Pro Gly 
        35                  40                  45              


Gly Ala Gly Gly Gly Gly Gly Val Val Gly Ala Gly Ser Gly Glu Asp 
    50                  55                  60                  


Asn Arg Ser Ser Ala Gly Glu Pro Gly Ser Ala Gly Ala Gly Gly Asp 
65                  70                  75                  80  


Val Asn Gly Thr Ala Ala Val Gly Gly Leu Val Val Ser Ala Gln Gly 
                85                  90                  95      


Val Gly Val Gly Val Phe Leu Ala Ala Phe Ile Leu Met Ala Val Ala 
            100                 105                 110         


Gly Asn Leu Leu Val Ile Leu Ser Val Ala Cys Asn Arg His Leu Gln 
        115                 120                 125             


Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ala Val Ala Asp Leu Leu 
    130                 135                 140                 


Leu Ser Ala Thr Val Leu Pro Phe Ser Ala Thr Met Glu Val Leu Gly 
145                 150                 155                 160 


Phe Trp Ala Phe Gly Arg Ala Phe Cys Asp Val Trp Ala Ala Val Asp 
                165                 170                 175     


Val Leu Cys Cys Thr Ala Ser Ile Leu Ser Leu Cys Thr Ile Ser Val 
            180                 185                 190         


Asp Arg Tyr Val Gly Val Arg His Ser Leu Lys Tyr Pro Ala Ile Met 
        195                 200                 205             


Thr Glu Arg Lys Ala Ala Ala Ile Leu Ala Leu Leu Trp Val Val Ala 
    210                 215                 220                 


Leu Val Val Ser Val Gly Pro Leu Leu Gly Trp Lys Glu Pro Val Pro 
225                 230                 235                 240 


Pro Asp Glu Arg Phe Cys Gly Ile Thr Glu Glu Ala Gly Tyr Ala Val 
                245                 250                 255     


Phe Ser Ser Val Cys Ser Phe Tyr Leu Pro Met Ala Val Ile Val Val 
            260                 265                 270         


Met Tyr Cys Arg Val Tyr Val Val Ala Arg Ser Thr Thr Arg Ser Leu 
        275                 280                 285             


Glu Ala Gly Val Lys Arg Glu Arg Gly Lys Ala Ser Glu Val Val Leu 
    290                 295                 300                 


Arg Ile His Cys Arg Gly Ala Ala Thr Gly Ala Asp Gly Ala His Gly 
305                 310                 315                 320 


Met Arg Ser Ala Lys Gly His Thr Phe Arg Ser Ser Leu Ser Val Arg 
                325                 330                 335     


Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys Thr Leu Ala Ile 
            340                 345                 350         


Val Val Gly Val Phe Val Leu Cys Trp Phe Pro Phe Phe Phe Val Leu 
        355                 360                 365             


Pro Leu Gly Ser Leu Phe Pro Gln Leu Lys Pro Ser Glu Gly Val Phe 
    370                 375                 380                 


Lys Val Ile Phe Trp Leu Gly Tyr Phe Asn Ser Cys Val Asn Pro Leu 
385                 390                 395                 400 


Ile Tyr Pro Cys Ser Ser Arg Glu Phe Lys Arg Ala Phe Leu Arg Leu 
                405                 410                 415     


Leu Arg Cys Gln Cys Arg Arg Arg Arg Arg Arg Arg Pro Leu Trp Arg 
            420                 425                 430         


Val Tyr Gly His His Trp Arg Ala Ser Thr Ser Gly Leu Arg Gln Asp 
        435                 440                 445             


Cys Ala Pro Ser Ser Gly Asp Ala Pro Pro Gly Ala Pro Leu Ala Leu 
    450                 455                 460                 


Thr Ala Leu Pro Asp Pro Asp Pro Glu Pro Pro Gly Thr Pro Glu Met 
465                 470                 475                 480 


Gln Ala Pro Val Ala Ser Arg Arg Lys Pro Pro Ser Ala Phe Arg Glu 
                485                 490                 495     


Trp Arg Leu Leu Gly Pro Phe Arg Arg Pro Thr Thr Gln Leu Arg Ala 
            500                 505                 510         


Lys Val Ser Ser Leu Ser His Lys Ile Arg Ala Gly Gly Ala Gln Arg 
        515                 520                 525             


Ala Glu Ala Ala Cys Ala Gln Arg Ser Glu Val Glu Ala Val Ser Leu 
    530                 535                 540                 


Gly Val Pro His Glu Val Ala Glu Gly Ala Thr Cys Gln Ala Tyr Glu 
545                 550                 555                 560 


Leu Ala Asp Tyr Ser Asn Leu Arg Glu Thr Asp Ile 
                565                 570         


<210>  303
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRA2A__Homo_sapiens__NP_000672

<400>  303

Met Phe Arg Gln Glu Gln Pro Leu Ala Glu Gly Ser Phe Ala Pro Met 
1               5                   10                  15      


Gly Ser Leu Gln Pro Asp Ala Gly Asn Ala Ser Trp Asn Gly Thr Glu 
            20                  25                  30          


Ala Pro Gly Gly Gly Ala Arg Ala Thr Pro Tyr Ser Leu Gln Val Thr 
        35                  40                  45              


Leu Thr Leu Val Cys Leu Ala Gly Leu Leu Met Leu Leu Thr Val Phe 
    50                  55                  60                  


Gly Asn Val Leu Val Ile Ile Ala Val Phe Thr Ser Arg Ala Leu Lys 
65                  70                  75                  80  


Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala Asp Ile Leu 
                85                  90                  95      


Val Ala Thr Leu Val Ile Pro Phe Ser Leu Ala Asn Glu Val Met Gly 
            100                 105                 110         


Tyr Trp Tyr Phe Gly Lys Ala Trp Cys Glu Ile Tyr Leu Ala Leu Asp 
        115                 120                 125             


Val Leu Phe Cys Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu 
    130                 135                 140                 


Asp Arg Tyr Trp Ser Ile Thr Gln Ala Ile Glu Tyr Asn Leu Lys Arg 
145                 150                 155                 160 


Thr Pro Arg Arg Ile Lys Ala Ile Ile Ile Thr Val Trp Val Ile Ser 
                165                 170                 175     


Ala Val Ile Ser Phe Pro Pro Leu Ile Ser Ile Glu Lys Lys Gly Gly 
            180                 185                 190         


Gly Gly Gly Pro Gln Pro Ala Glu Pro Arg Cys Glu Ile Asn Asp Gln 
        195                 200                 205             


Lys Trp Tyr Val Ile Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys 
    210                 215                 220                 


Leu Ile Met Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys Arg 
225                 230                 235                 240 


Arg Thr Arg Val Pro Pro Ser Arg Arg Gly Pro Asp Ala Val Ala Ala 
                245                 250                 255     


Pro Pro Gly Gly Thr Glu Arg Arg Pro Asn Gly Leu Gly Pro Glu Arg 
            260                 265                 270         


Ser Ala Gly Pro Gly Gly Ala Glu Ala Glu Pro Leu Pro Thr Gln Leu 
        275                 280                 285             


Asn Gly Ala Pro Gly Glu Pro Ala Pro Ala Gly Pro Arg Asp Thr Asp 
    290                 295                 300                 


Ala Leu Asp Leu Glu Glu Ser Ser Ser Ser Asp His Ala Glu Arg Pro 
305                 310                 315                 320 


Pro Gly Pro Arg Arg Pro Glu Arg Gly Pro Arg Gly Lys Gly Lys Ala 
                325                 330                 335     


Arg Ala Ser Gln Val Lys Pro Gly Asp Ser Leu Pro Arg Arg Gly Pro 
            340                 345                 350         


Gly Ala Thr Gly Ile Gly Thr Pro Ala Ala Gly Pro Gly Glu Glu Arg 
        355                 360                 365             


Val Gly Ala Ala Lys Ala Ser Arg Trp Arg Gly Arg Gln Asn Arg Glu 
    370                 375                 380                 


Lys Arg Phe Thr Phe Val Leu Ala Val Val Ile Gly Val Phe Val Val 
385                 390                 395                 400 


Cys Trp Phe Pro Phe Phe Phe Thr Tyr Thr Leu Thr Ala Val Gly Cys 
                405                 410                 415     


Ser Val Pro Arg Thr Leu Phe Lys Phe Phe Phe Trp Phe Gly Tyr Cys 
            420                 425                 430         


Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn His Asp Phe 
        435                 440                 445             


Arg Arg Ala Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys Arg Ile 
    450                 455                 460                 


Val 
465 


<210>  304
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRA2B__Homo_sapiens__NP_000673

<400>  304

Met Asp His Gln Asp Pro Tyr Ser Val Gln Ala Thr Ala Ala Ile Ala 
1               5                   10                  15      


Ala Ala Ile Thr Phe Leu Ile Leu Phe Thr Ile Phe Gly Asn Ala Leu 
            20                  25                  30          


Val Ile Leu Ala Val Leu Thr Ser Arg Ser Leu Arg Ala Pro Gln Asn 
        35                  40                  45              


Leu Phe Leu Val Ser Leu Ala Ala Ala Asp Ile Leu Val Ala Thr Leu 
    50                  55                  60                  


Ile Ile Pro Phe Ser Leu Ala Asn Glu Leu Leu Gly Tyr Trp Tyr Phe 
65                  70                  75                  80  


Arg Arg Thr Trp Cys Glu Val Tyr Leu Ala Leu Asp Val Leu Phe Cys 
                85                  90                  95      


Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Trp 
            100                 105                 110         


Ala Val Ser Arg Ala Leu Glu Tyr Asn Ser Lys Arg Thr Pro Arg Arg 
        115                 120                 125             


Ile Lys Cys Ile Ile Leu Thr Val Trp Leu Ile Ala Ala Val Ile Ser 
    130                 135                 140                 


Leu Pro Pro Leu Ile Tyr Lys Gly Asp Gln Gly Pro Gln Pro Arg Gly 
145                 150                 155                 160 


Arg Pro Gln Cys Lys Leu Asn Gln Glu Ala Trp Tyr Ile Leu Ala Ser 
                165                 170                 175     


Ser Ile Gly Ser Phe Phe Ala Pro Cys Leu Ile Met Ile Leu Val Tyr 
            180                 185                 190         


Leu Arg Ile Tyr Leu Ile Ala Lys Arg Ser Asn Arg Arg Gly Pro Arg 
        195                 200                 205             


Ala Lys Gly Gly Pro Gly Gln Gly Glu Ser Lys Gln Pro Arg Pro Asp 
    210                 215                 220                 


His Gly Gly Ala Leu Ala Ser Ala Lys Leu Pro Ala Leu Ala Ser Val 
225                 230                 235                 240 


Ala Ser Ala Arg Glu Val Asn Gly His Ser Lys Ser Thr Gly Glu Lys 
                245                 250                 255     


Glu Glu Gly Glu Thr Pro Glu Asp Thr Gly Thr Arg Ala Leu Pro Pro 
            260                 265                 270         


Ser Trp Ala Ala Leu Pro Asn Ser Gly Gln Gly Gln Lys Glu Gly Val 
        275                 280                 285             


Cys Gly Ala Ser Pro Glu Asp Glu Ala Glu Glu Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Cys Glu Pro Gln Ala Val Pro Val Ser Pro Ala 
305                 310                 315                 320 


Ser Ala Cys Ser Pro Pro Leu Gln Gln Pro Gln Gly Ser Arg Val Leu 
                325                 330                 335     


Ala Thr Leu Arg Gly Gln Val Leu Leu Gly Arg Gly Val Gly Ala Ile 
            340                 345                 350         


Gly Gly Gln Trp Trp Arg Arg Arg Ala Gln Leu Thr Arg Glu Lys Arg 
        355                 360                 365             


Phe Thr Phe Val Leu Ala Val Val Ile Gly Val Phe Val Leu Cys Trp 
    370                 375                 380                 


Phe Pro Phe Phe Phe Ser Tyr Ser Leu Gly Ala Ile Cys Pro Lys His 
385                 390                 395                 400 


Cys Lys Val Pro His Gly Leu Phe Gln Phe Phe Phe Trp Ile Gly Tyr 
                405                 410                 415     


Cys Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn Gln Asp 
            420                 425                 430         


Phe Arg Arg Ala Phe Arg Arg Ile Leu Cys Arg Pro Trp Thr Gln Thr 
        435                 440                 445             


Ala Trp 
    450 


<210>  305
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRA2C__Homo_sapiens__NP_000674

<400>  305

Met Ala Ser Pro Ala Leu Ala Ala Ala Leu Ala Val Ala Ala Ala Ala 
1               5                   10                  15      


Gly Pro Asn Ala Ser Gly Ala Gly Glu Arg Gly Ser Gly Gly Val Ala 
            20                  25                  30          


Asn Ala Ser Gly Ala Ser Trp Gly Pro Pro Arg Gly Gln Tyr Ser Ala 
        35                  40                  45              


Gly Ala Val Ala Gly Leu Ala Ala Val Val Gly Phe Leu Ile Val Phe 
    50                  55                  60                  


Thr Val Val Gly Asn Val Leu Val Val Ile Ala Val Leu Thr Ser Arg 
65                  70                  75                  80  


Ala Leu Arg Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala 
                85                  90                  95      


Asp Ile Leu Val Ala Thr Leu Val Met Pro Phe Ser Leu Ala Asn Glu 
            100                 105                 110         


Leu Met Ala Tyr Trp Tyr Phe Gly Gln Val Trp Cys Gly Val Tyr Leu 
        115                 120                 125             


Ala Leu Asp Val Leu Phe Cys Thr Ser Ser Ile Val His Leu Cys Ala 
    130                 135                 140                 


Ile Ser Leu Asp Arg Tyr Trp Ser Val Thr Gln Ala Val Glu Tyr Asn 
145                 150                 155                 160 


Leu Lys Arg Thr Pro Arg Arg Val Lys Ala Thr Ile Val Ala Val Trp 
                165                 170                 175     


Leu Ile Ser Ala Val Ile Ser Phe Pro Pro Leu Val Ser Leu Tyr Arg 
            180                 185                 190         


Gln Pro Asp Gly Ala Ala Tyr Pro Gln Cys Gly Leu Asn Asp Glu Thr 
        195                 200                 205             


Trp Tyr Ile Leu Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys Leu 
    210                 215                 220                 


Ile Met Gly Leu Val Tyr Ala Arg Ile Tyr Arg Val Ala Lys Leu Arg 
225                 230                 235                 240 


Thr Arg Thr Leu Ser Glu Lys Arg Ala Pro Val Gly Pro Asp Gly Ala 
                245                 250                 255     


Ser Pro Thr Thr Glu Asn Gly Leu Gly Ala Ala Ala Gly Ala Gly Glu 
            260                 265                 270         


Asn Gly His Cys Ala Pro Pro Pro Ala Asp Val Glu Pro Asp Glu Ser 
        275                 280                 285             


Ser Ala Ala Ala Glu Arg Arg Arg Arg Arg Gly Ala Leu Arg Arg Gly 
    290                 295                 300                 


Gly Arg Arg Arg Ala Gly Ala Glu Gly Gly Ala Gly Gly Ala Asp Gly 
305                 310                 315                 320 


Gln Gly Ala Gly Pro Gly Ala Ala Glu Ser Gly Ala Leu Thr Ala Ser 
                325                 330                 335     


Arg Ser Pro Gly Pro Gly Gly Arg Leu Ser Arg Ala Ser Ser Arg Ser 
            340                 345                 350         


Val Glu Phe Phe Leu Ser Arg Arg Arg Arg Ala Arg Ser Ser Val Cys 
        355                 360                 365             


Arg Arg Lys Val Ala Gln Ala Arg Glu Lys Arg Phe Thr Phe Val Leu 
    370                 375                 380                 


Ala Val Val Met Gly Val Phe Val Leu Cys Trp Phe Pro Phe Phe Phe 
385                 390                 395                 400 


Ser Tyr Ser Leu Tyr Gly Ile Cys Arg Glu Ala Cys Gln Val Pro Gly 
                405                 410                 415     


Pro Leu Phe Lys Phe Phe Phe Trp Ile Gly Tyr Cys Asn Ser Ser Leu 
            420                 425                 430         


Asn Pro Val Ile Tyr Thr Val Phe Asn Gln Asp Phe Arg Arg Ser Phe 
        435                 440                 445             


Lys His Ile Leu Phe Arg Arg Arg Arg Arg Gly Phe Arg Gln 
    450                 455                 460         


<210>  306
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRB1__Homo_sapiens__NP_000675

<400>  306

Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      


Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu 
            20                  25                  30          


Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              


Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu 
    50                  55                  60                  


Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  


Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe 
                85                  90                  95      


Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         


Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             


Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala 
    130                 135                 140                 


Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 


Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg 
                165                 170                 175     


Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         


Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             


Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr 
    210                 215                 220                 


Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 


Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     


Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         


Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             


Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 


Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln 
305                 310                 315                 320 


Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly Val Phe Thr Leu Cys 
                325                 330                 335     


Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu 
            340                 345                 350         


Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala 
        355                 360                 365             


Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg 
    370                 375                 380                 


Lys Ala Phe Gln Gly Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg 
385                 390                 395                 400 


Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala 
                405                 410                 415     


Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp 
            420                 425                 430         


Asp Asp Val Val Gly Ala Thr Pro Pro Ala Arg Leu Leu Glu Pro Trp 
        435                 440                 445             


Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp 
    450                 455                 460                 


Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val 
465                 470                 475         


<210>  307
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRB2__Homo_sapiens__NP_000015

<400>  307

Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


<210>  308
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRB3__Homo_sapiens__NP_000016

<400>  308

Met Ala Pro Trp Pro His Glu Asn Ser Ser Leu Ala Pro Trp Pro Asp 
1               5                   10                  15      


Leu Pro Thr Leu Ala Pro Asn Thr Ala Asn Thr Ser Gly Leu Pro Gly 
            20                  25                  30          


Val Pro Trp Glu Ala Ala Leu Ala Gly Ala Leu Leu Ala Leu Ala Val 
        35                  40                  45              


Leu Ala Thr Val Gly Gly Asn Leu Leu Val Ile Val Ala Ile Ala Trp 
    50                  55                  60                  


Thr Pro Arg Leu Gln Thr Met Thr Asn Val Phe Val Thr Ser Leu Ala 
65                  70                  75                  80  


Ala Ala Asp Leu Val Met Gly Leu Leu Val Val Pro Pro Ala Ala Thr 
                85                  90                  95      


Leu Ala Leu Thr Gly His Trp Pro Leu Gly Ala Thr Gly Cys Glu Leu 
            100                 105                 110         


Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu 
        115                 120                 125             


Cys Ala Leu Ala Val Asp Arg Tyr Leu Ala Val Thr Asn Pro Leu Arg 
    130                 135                 140                 


Tyr Gly Ala Leu Val Thr Lys Arg Cys Ala Arg Thr Ala Val Val Leu 
145                 150                 155                 160 


Val Trp Val Val Ser Ala Ala Val Ser Phe Ala Pro Ile Met Ser Gln 
                165                 170                 175     


Trp Trp Arg Val Gly Ala Asp Ala Glu Ala Gln Arg Cys His Ser Asn 
            180                 185                 190         


Pro Arg Cys Cys Ala Phe Ala Ser Asn Met Pro Tyr Val Leu Leu Ser 
        195                 200                 205             


Ser Ser Val Ser Phe Tyr Leu Pro Leu Leu Val Met Leu Phe Val Tyr 
    210                 215                 220                 


Ala Arg Val Phe Val Val Ala Thr Arg Gln Leu Arg Leu Leu Arg Gly 
225                 230                 235                 240 


Glu Leu Gly Arg Phe Pro Pro Glu Glu Ser Pro Pro Ala Pro Ser Arg 
                245                 250                 255     


Ser Leu Ala Pro Ala Pro Val Gly Thr Cys Ala Pro Pro Glu Gly Val 
            260                 265                 270         


Pro Ala Cys Gly Arg Arg Pro Ala Arg Leu Leu Pro Leu Arg Glu His 
        275                 280                 285             


Arg Ala Leu Cys Thr Leu Gly Leu Ile Met Gly Thr Phe Thr Leu Cys 
    290                 295                 300                 


Trp Leu Pro Phe Phe Leu Ala Asn Val Leu Arg Ala Leu Gly Gly Pro 
305                 310                 315                 320 


Ser Leu Val Pro Gly Pro Ala Phe Leu Ala Leu Asn Trp Leu Gly Tyr 
                325                 330                 335     


Ala Asn Ser Ala Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe 
            340                 345                 350         


Arg Ser Ala Phe Arg Arg Leu Leu Cys Arg Cys Gly Arg Arg Leu Pro 
        355                 360                 365             


Pro Glu Pro Cys Ala Ala Ala Arg Pro Ala Leu Phe Pro Ser Gly Val 
    370                 375                 380                 


Pro Ala Ala Arg Ser Ser Pro Ala Gln Pro Arg Leu Cys Gln Arg Leu 
385                 390                 395                 400 


Asp Gly Ala Ser Trp Gly Val Ser 
                405             


<210>  309
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRBK1__Homo_sapiens__NP_001610

<400>  309

Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Lys Ile 
            20                  25                  30          


Leu Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Glu 
        35                  40                  45              


Asp Arg Gly Glu Val Thr Phe Glu Lys Ile Phe Ser Gln Lys Leu Gly 
    50                  55                  60                  


Tyr Leu Leu Phe Arg Asp Phe Cys Leu Asn His Leu Glu Glu Ala Arg 
65                  70                  75                  80  


Pro Leu Val Glu Phe Tyr Glu Glu Ile Lys Lys Tyr Glu Lys Leu Glu 
                85                  90                  95      


Thr Glu Glu Glu Arg Val Ala Arg Ser Arg Glu Ile Phe Asp Ser Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ala Cys Ser His Pro Phe Ser Lys Ser Ala 
        115                 120                 125             


Thr Glu His Val Gln Gly His Leu Gly Lys Lys Gln Val Pro Pro Asp 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Gln Asn Leu Arg Gly Asp 
145                 150                 155                 160 


Val Phe Gln Lys Phe Ile Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Asp Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Ala Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Ser Tyr Ala Phe His Thr Pro Asp Lys Leu Ser Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Ala Asp Met Arg Phe Tyr Ala Ala Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Met His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Val Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Val Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Met Ala Val Glu Leu Pro Asp Ser 
                405                 410                 415     


Phe Ser Pro Glu Leu Arg Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Asn Arg Arg Leu Gly Cys Leu Gly Arg Gly Ala Gln Glu Val Lys 
        435                 440                 445             


Glu Ser Pro Phe Phe Arg Ser Leu Asp Trp Gln Met Val Phe Leu Gln 
    450                 455                 460                 


Lys Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Ser Asp Gln Glu Leu Tyr Arg Asn Phe Pro Leu Thr 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Ala Glu Thr Val Phe Asp Thr 
        515                 520                 525             


Ile Asn Ala Glu Thr Asp Arg Leu Glu Ala Arg Lys Lys Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Ser Lys Met Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ala Pro Gln Ser Leu Leu Thr Met Glu Glu Ile Gln Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Glu Arg Lys Cys Leu Leu Leu Lys Ile 
    610                 615                 620                 


Arg Gly Gly Lys Gln Phe Ile Leu Gln Cys Asp Ser Asp Pro Glu Leu 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Arg Asp Ala Tyr Arg Glu Ala Gln Gln 
                645                 650                 655     


Leu Val Gln Arg Val Pro Lys Met Lys Asn Lys Pro Arg Ser Pro Val 
            660                 665                 670         


Val Glu Leu Ser Lys Val Pro Leu Val Gln Arg Gly Ser Ala Asn Gly 
        675                 680                 685             


Leu 
    


<210>  310
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRBK2__Homo_sapiens__NP_005151

<400>  310

Met Ala Asp Leu Glu Ala Val Leu Ala Asp Val Ser Tyr Leu Met Ala 
1               5                   10                  15      


Met Glu Lys Ser Lys Ala Thr Pro Ala Ala Arg Ala Ser Lys Arg Ile 
            20                  25                  30          


Val Leu Pro Glu Pro Ser Ile Arg Ser Val Met Gln Lys Tyr Leu Ala 
        35                  40                  45              


Glu Arg Asn Glu Ile Thr Phe Asp Lys Ile Phe Asn Gln Lys Ile Gly 
    50                  55                  60                  


Phe Leu Leu Phe Lys Asp Phe Cys Leu Asn Glu Ile Asn Glu Ala Val 
65                  70                  75                  80  


Pro Gln Val Lys Phe Tyr Glu Glu Ile Lys Glu Tyr Glu Lys Leu Asp 
                85                  90                  95      


Asn Glu Glu Asp Arg Leu Cys Arg Ser Arg Gln Ile Tyr Asp Ala Tyr 
            100                 105                 110         


Ile Met Lys Glu Leu Leu Ser Cys Ser His Pro Phe Ser Lys Gln Ala 
        115                 120                 125             


Val Glu His Val Gln Ser His Leu Ser Lys Lys Gln Val Thr Ser Thr 
    130                 135                 140                 


Leu Phe Gln Pro Tyr Ile Glu Glu Ile Cys Glu Ser Leu Arg Gly Asp 
145                 150                 155                 160 


Ile Phe Gln Lys Phe Met Glu Ser Asp Lys Phe Thr Arg Phe Cys Gln 
                165                 170                 175     


Trp Lys Asn Val Glu Leu Asn Ile His Leu Thr Met Asn Glu Phe Ser 
            180                 185                 190         


Val His Arg Ile Ile Gly Arg Gly Gly Phe Gly Glu Val Tyr Gly Cys 
        195                 200                 205             


Arg Lys Ala Asp Thr Gly Lys Met Tyr Ala Met Lys Cys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Ile Lys Met Lys Gln Gly Glu Thr Leu Ala Leu Asn Glu Arg 
225                 230                 235                 240 


Ile Met Leu Ser Leu Val Ser Thr Gly Asp Cys Pro Phe Ile Val Cys 
                245                 250                 255     


Met Thr Tyr Ala Phe His Thr Pro Asp Lys Leu Cys Phe Ile Leu Asp 
            260                 265                 270         


Leu Met Asn Gly Gly Asp Leu His Tyr His Leu Ser Gln His Gly Val 
        275                 280                 285             


Phe Ser Glu Lys Glu Met Arg Phe Tyr Ala Thr Glu Ile Ile Leu Gly 
    290                 295                 300                 


Leu Glu His Met His Asn Arg Phe Val Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Ala Asn Ile Leu Leu Asp Glu His Gly His Ala Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Cys Asp Phe Ser Lys Lys Lys Pro His Ala Ser Val Gly 
            340                 345                 350         


Thr His Gly Tyr Met Ala Pro Glu Val Leu Gln Lys Gly Thr Ala Tyr 
        355                 360                 365             


Asp Ser Ser Ala Asp Trp Phe Ser Leu Gly Cys Met Leu Phe Lys Leu 
    370                 375                 380                 


Leu Arg Gly His Ser Pro Phe Arg Gln His Lys Thr Lys Asp Lys His 
385                 390                 395                 400 


Glu Ile Asp Arg Met Thr Leu Thr Val Asn Val Glu Leu Pro Asp Thr 
                405                 410                 415     


Phe Ser Pro Glu Leu Lys Ser Leu Leu Glu Gly Leu Leu Gln Arg Asp 
            420                 425                 430         


Val Ser Lys Arg Leu Gly Cys His Gly Gly Gly Ser Gln Glu Val Lys 
        435                 440                 445             


Glu His Ser Phe Phe Lys Gly Val Asp Trp Gln His Val Tyr Leu Gln 
    450                 455                 460                 


Lys Tyr Pro Pro Pro Leu Ile Pro Pro Arg Gly Glu Val Asn Ala Ala 
465                 470                 475                 480 


Asp Ala Phe Asp Ile Gly Ser Phe Asp Glu Glu Asp Thr Lys Gly Ile 
                485                 490                 495     


Lys Leu Leu Asp Cys Asp Gln Glu Leu Tyr Lys Asn Phe Pro Leu Val 
            500                 505                 510         


Ile Ser Glu Arg Trp Gln Gln Glu Val Thr Glu Thr Val Tyr Glu Ala 
        515                 520                 525             


Val Asn Ala Asp Thr Asp Lys Ile Glu Ala Arg Lys Arg Ala Lys Asn 
    530                 535                 540                 


Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu Gly Lys Asp Cys Ile 
545                 550                 555                 560 


Met His Gly Tyr Met Leu Lys Leu Gly Asn Pro Phe Leu Thr Gln Trp 
                565                 570                 575     


Gln Arg Arg Tyr Phe Tyr Leu Phe Pro Asn Arg Leu Glu Trp Arg Gly 
            580                 585                 590         


Glu Gly Glu Ser Arg Gln Asn Leu Leu Thr Met Glu Gln Ile Leu Ser 
        595                 600                 605             


Val Glu Glu Thr Gln Ile Lys Asp Lys Lys Cys Ile Leu Phe Arg Ile 
    610                 615                 620                 


Lys Gly Gly Lys Gln Phe Val Leu Gln Cys Glu Ser Asp Pro Glu Phe 
625                 630                 635                 640 


Val Gln Trp Lys Lys Glu Leu Asn Glu Thr Phe Lys Glu Ala Gln Arg 
                645                 650                 655     


Leu Leu Arg Arg Ala Pro Lys Phe Leu Asn Lys Pro Arg Ser Gly Thr 
            660                 665                 670         


Val Glu Leu Pro Lys Pro Ser Leu Cys His Arg Asn Ser Asn Gly Leu 
        675                 680                 685             


<210>  311
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADRM1__Homo_sapiens__XP_011526804

<400>  311

Met Thr Thr Ser Gly Ala Leu Phe Pro Ser Leu Val Pro Gly Ser Arg 
1               5                   10                  15      


Gly Ala Ser Asn Lys Tyr Leu Val Glu Phe Arg Ala Gly Lys Met Ser 
            20                  25                  30          


Leu Lys Gly Thr Thr Val Thr Pro Asp Lys Arg Lys Gly Leu Val Tyr 
        35                  40                  45              


Ile Gln Gln Thr Asp Asp Ser Leu Ile His Phe Cys Trp Lys Asp Arg 
    50                  55                  60                  


Thr Ser Gly Asn Val Glu Asp Asp Leu Ile Ile Phe Pro Asp Asp Cys 
65                  70                  75                  80  


Glu Phe Lys Arg Val Pro Gln Cys Pro Ser Gly Arg Val Tyr Val Leu 
                85                  90                  95      


Lys Phe Lys Ala Gly Ser Lys Arg Leu Phe Phe Trp Met Gln Glu Pro 
            100                 105                 110         


Lys Thr Asp Gln Asp Glu Glu His Cys Arg Lys Val Asn Glu Tyr Leu 
        115                 120                 125             


Asn Asn Pro Pro Met Pro Gly Ala Leu Gly Ala Ser Gly Ser Ser Gly 
    130                 135                 140                 


His Glu Leu Ser Ala Leu Gly Gly Glu Gly Gly Leu Gln Ser Leu Leu 
145                 150                 155                 160 


Gly Asn Met Ser His Ser Gln Leu Met Gln Leu Ile Gly Pro Ala Gly 
                165                 170                 175     


Leu Gly Gly Leu Gly Gly Leu Gly Ala Leu Thr Gly Pro Gly Leu Ala 
            180                 185                 190         


Ser Leu Leu Gly Ser Ser Gly Pro Pro Gly Ser Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Arg Ser Gln Ser Ala Ala Val Thr Pro Ser Ser Thr Thr Ser Ser 
    210                 215                 220                 


Thr Arg Ala Thr Pro Ala Pro Ser Ala Pro Ala Ala Ala Ser Ala Thr 
225                 230                 235                 240 


Ser Pro Ser Pro Ala Pro Ser Ser Gly Asn Gly Ala Ser Thr Ala Ala 
                245                 250                 255     


Ser Pro Thr Gln Pro Ile Gln Leu Ser Asp Leu Gln Ser Ile Leu Ala 
            260                 265                 270         


Thr Met Asn Val Pro Ala Gly Pro Ala Gly Gly Gln Gln Val Asp Leu 
        275                 280                 285             


Ala Ser Val Leu Thr Pro Glu Ile Met Ala Pro Ile Leu Ala Asn Ala 
    290                 295                 300                 


Asp Val Gln Glu Arg Leu Leu Pro Tyr Leu Pro Ser Gly Glu Ser Leu 
305                 310                 315                 320 


Pro Gln Thr Ala Asp Glu Ile Gln Asn Thr Leu Thr Ser Pro Gln Phe 
                325                 330                 335     


Gln Gln Ala Leu Gly Met Phe Ser Ala Ala Leu Ala Ser Gly Gln Leu 
            340                 345                 350         


Gly Pro Leu Met Cys Gln Phe Gly Leu Pro Ala Glu Ala Val Glu Ala 
        355                 360                 365             


Ala Asn Lys Gly Asp Val Glu Ala Phe Ala Lys Ala Met Gln Asn Asn 
    370                 375                 380                 


Ala Lys Pro Glu Gln Lys Glu Gly Asp Thr Lys Asp Lys Lys Asp Glu 
385                 390                 395                 400 


Glu Glu Asp Met Ser Leu Asp 
                405         


<210>  312
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADSL__Homo_sapiens__NP_000017

<400>  312

Met Ala Ala Gly Gly Asp His Gly Ser Pro Asp Ser Tyr Arg Ser Pro 
1               5                   10                  15      


Leu Ala Ser Arg Tyr Ala Ser Pro Glu Met Cys Phe Val Phe Ser Asp 
            20                  25                  30          


Arg Tyr Lys Phe Arg Thr Trp Arg Gln Leu Trp Leu Trp Leu Ala Glu 
        35                  40                  45              


Ala Glu Gln Thr Leu Gly Leu Pro Ile Thr Asp Glu Gln Ile Gln Glu 
    50                  55                  60                  


Met Lys Ser Asn Leu Glu Asn Ile Asp Phe Lys Met Ala Ala Glu Glu 
65                  70                  75                  80  


Glu Lys Arg Leu Arg His Asp Val Met Ala His Val His Thr Phe Gly 
                85                  90                  95      


His Cys Cys Pro Lys Ala Ala Gly Ile Ile His Leu Gly Ala Thr Ser 
            100                 105                 110         


Cys Tyr Val Gly Asp Asn Thr Asp Leu Ile Ile Leu Arg Asn Ala Leu 
        115                 120                 125             


Asp Leu Leu Leu Pro Lys Leu Ala Arg Val Ile Ser Arg Leu Ala Asp 
    130                 135                 140                 


Phe Ala Lys Glu Arg Ala Ser Leu Pro Thr Leu Gly Phe Thr His Phe 
145                 150                 155                 160 


Gln Pro Ala Gln Leu Thr Thr Val Gly Lys Arg Cys Cys Leu Trp Ile 
                165                 170                 175     


Gln Asp Leu Cys Met Asp Leu Gln Asn Leu Lys Arg Val Arg Asp Asp 
            180                 185                 190         


Leu Arg Phe Arg Gly Val Lys Gly Thr Thr Gly Thr Gln Ala Ser Phe 
        195                 200                 205             


Leu Gln Leu Phe Glu Gly Asp Asp His Lys Val Glu Gln Leu Asp Lys 
    210                 215                 220                 


Met Val Thr Glu Lys Ala Gly Phe Lys Arg Ala Phe Ile Ile Thr Gly 
225                 230                 235                 240 


Gln Thr Tyr Thr Arg Lys Val Asp Ile Glu Val Leu Ser Val Leu Ala 
                245                 250                 255     


Ser Leu Gly Ala Ser Val His Lys Ile Cys Thr Asp Ile Arg Leu Leu 
            260                 265                 270         


Ala Asn Leu Lys Glu Met Glu Glu Pro Phe Glu Lys Gln Gln Ile Gly 
        275                 280                 285             


Ser Ser Ala Met Pro Tyr Lys Arg Asn Pro Met Arg Ser Glu Arg Cys 
    290                 295                 300                 


Cys Ser Leu Ala Arg His Leu Met Thr Leu Val Met Asp Pro Leu Gln 
305                 310                 315                 320 


Thr Ala Ser Val Gln Trp Phe Glu Arg Thr Leu Asp Asp Ser Ala Asn 
                325                 330                 335     


Arg Arg Ile Cys Leu Ala Glu Ala Phe Leu Thr Ala Asp Thr Ile Leu 
            340                 345                 350         


Asn Thr Leu Gln Asn Ile Ser Glu Gly Leu Val Val Tyr Pro Lys Val 
        355                 360                 365             


Ile Glu Arg Arg Ile Arg Gln Glu Leu Pro Phe Met Ala Thr Glu Asn 
    370                 375                 380                 


Ile Ile Met Ala Met Val Lys Ala Gly Gly Ser Arg Gln Asp Cys His 
385                 390                 395                 400 


Glu Lys Ile Arg Val Leu Ser Gln Gln Ala Ala Ser Val Val Lys Gln 
                405                 410                 415     


Glu Gly Gly Asp Asn Asp Leu Ile Glu Arg Ile Gln Val Asp Ala Tyr 
            420                 425                 430         


Phe Ser Pro Ile His Ser Gln Leu Asp His Leu Leu Asp Pro Ser Ser 
        435                 440                 445             


Phe Thr Gly Arg Ala Ser Gln Gln Val Gln Arg Phe Leu Glu Glu Glu 
    450                 455                 460                 


Val Tyr Pro Leu Leu Lys Pro Tyr Glu Ser Val Met Lys Val Lys Ala 
465                 470                 475                 480 


Glu Leu Cys Leu 
                


<210>  313
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADSS__Homo_sapiens__NP_001117

<400>  313

Met Ala Phe Ala Glu Thr Tyr Pro Ala Ala Ser Ser Leu Pro Asn Gly 
1               5                   10                  15      


Asp Cys Gly Arg Pro Arg Ala Arg Pro Gly Gly Asn Arg Val Thr Val 
            20                  25                  30          


Val Leu Gly Ala Gln Trp Gly Asp Glu Gly Lys Gly Lys Val Val Asp 
        35                  40                  45              


Leu Leu Ala Gln Asp Ala Asp Ile Val Cys Arg Cys Gln Gly Gly Asn 
    50                  55                  60                  


Asn Ala Gly His Thr Val Val Val Asp Ser Val Glu Tyr Asp Phe His 
65                  70                  75                  80  


Leu Leu Pro Ser Gly Ile Ile Asn Pro Asn Val Thr Ala Phe Ile Gly 
                85                  90                  95      


Asn Gly Val Val Ile His Leu Pro Gly Leu Phe Glu Glu Ala Glu Lys 
            100                 105                 110         


Asn Val Gln Lys Gly Lys Gly Leu Glu Gly Trp Glu Lys Arg Leu Ile 
        115                 120                 125             


Ile Ser Asp Arg Ala His Ile Val Phe Asp Phe His Gln Ala Ala Asp 
    130                 135                 140                 


Gly Ile Gln Glu Gln Gln Arg Gln Glu Gln Ala Gly Lys Asn Leu Gly 
145                 150                 155                 160 


Thr Thr Lys Lys Gly Ile Gly Pro Val Tyr Ser Ser Lys Ala Ala Arg 
                165                 170                 175     


Ser Gly Leu Arg Met Cys Asp Leu Val Ser Asp Phe Asp Gly Phe Ser 
            180                 185                 190         


Glu Arg Phe Lys Val Leu Ala Asn Gln Tyr Lys Ser Ile Tyr Pro Thr 
        195                 200                 205             


Leu Glu Ile Asp Ile Glu Gly Glu Leu Gln Lys Leu Lys Gly Tyr Met 
    210                 215                 220                 


Glu Lys Ile Lys Pro Met Val Arg Asp Gly Val Tyr Phe Leu Tyr Glu 
225                 230                 235                 240 


Ala Leu His Gly Pro Pro Lys Lys Ile Leu Val Glu Gly Ala Asn Ala 
                245                 250                 255     


Ala Leu Leu Asp Ile Asp Phe Gly Thr Tyr Pro Phe Val Thr Ser Ser 
            260                 265                 270         


Asn Cys Thr Val Gly Gly Val Cys Thr Gly Leu Gly Met Pro Pro Gln 
        275                 280                 285             


Asn Val Gly Glu Val Tyr Gly Val Val Lys Ala Tyr Thr Thr Arg Val 
    290                 295                 300                 


Gly Ile Gly Ala Phe Pro Thr Glu Gln Asp Asn Glu Ile Gly Glu Leu 
305                 310                 315                 320 


Leu Gln Thr Arg Gly Arg Glu Phe Gly Val Thr Thr Gly Arg Lys Arg 
                325                 330                 335     


Arg Cys Gly Trp Leu Asp Leu Val Leu Leu Lys Tyr Ala His Met Ile 
            340                 345                 350         


Asn Gly Phe Thr Ala Leu Ala Leu Thr Lys Leu Asp Ile Leu Asp Met 
        355                 360                 365             


Phe Thr Glu Ile Lys Val Gly Val Ala Tyr Lys Leu Asp Gly Glu Ile 
    370                 375                 380                 


Ile Pro His Ile Pro Ala Asn Gln Glu Val Leu Asn Lys Val Glu Val 
385                 390                 395                 400 


Gln Tyr Lys Thr Leu Pro Gly Trp Asn Thr Asp Ile Ser Asn Ala Arg 
                405                 410                 415     


Ala Phe Lys Glu Leu Pro Val Asn Ala Gln Asn Tyr Val Arg Phe Ile 
            420                 425                 430         


Glu Asp Glu Leu Gln Ile Pro Val Lys Trp Ile Gly Val Gly Lys Ser 
        435                 440                 445             


Arg Glu Ser Met Ile Gln Leu Phe 
    450                 455     


<210>  314
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADSSL1__Homo_sapiens__NP_689541

<400>  314

Met Ser Gly Thr Arg Ala Ser Asn Asp Arg Pro Pro Gly Ala Gly Gly 
1               5                   10                  15      


Val Lys Arg Gly Arg Leu Gln Gln Glu Ala Ala Ala Thr Gly Ser Arg 
            20                  25                  30          


Val Thr Val Val Leu Gly Ala Gln Trp Gly Asp Glu Gly Lys Gly Lys 
        35                  40                  45              


Val Val Asp Leu Leu Ala Thr Asp Ala Asp Ile Ile Ser Arg Cys Gln 
    50                  55                  60                  


Gly Gly Asn Asn Ala Gly His Thr Val Val Val Asp Gly Lys Glu Tyr 
65                  70                  75                  80  


Asp Phe His Leu Leu Pro Ser Gly Ile Ile Asn Thr Lys Ala Val Ser 
                85                  90                  95      


Phe Ile Gly Asn Gly Val Val Ile His Leu Pro Gly Leu Phe Glu Glu 
            100                 105                 110         


Ala Glu Lys Asn Glu Lys Lys Gly Leu Lys Asp Trp Glu Lys Arg Leu 
        115                 120                 125             


Ile Ile Ser Asp Arg Ala His Leu Val Phe Asp Phe His Gln Ala Val 
    130                 135                 140                 


Asp Gly Leu Gln Glu Val Gln Arg Gln Ala Gln Glu Gly Lys Asn Ile 
145                 150                 155                 160 


Gly Thr Thr Lys Lys Gly Ile Gly Pro Thr Tyr Ser Ser Lys Ala Ala 
                165                 170                 175     


Arg Thr Gly Leu Arg Ile Cys Asp Leu Leu Ser Asp Phe Asp Glu Phe 
            180                 185                 190         


Ser Ser Arg Phe Lys Asn Leu Ala His Gln His Gln Ser Met Phe Pro 
        195                 200                 205             


Thr Leu Glu Ile Asp Ile Glu Gly Gln Leu Lys Arg Leu Lys Gly Phe 
    210                 215                 220                 


Ala Glu Arg Ile Arg Pro Met Val Arg Asp Gly Val Tyr Phe Met Tyr 
225                 230                 235                 240 


Glu Ala Leu His Gly Pro Pro Lys Lys Ile Leu Val Glu Gly Ala Asn 
                245                 250                 255     


Ala Ala Leu Leu Asp Ile Asp Phe Gly Thr Tyr Pro Phe Val Thr Ser 
            260                 265                 270         


Ser Asn Cys Thr Val Gly Gly Val Cys Thr Gly Leu Gly Ile Pro Pro 
        275                 280                 285             


Gln Asn Ile Gly Asp Val Tyr Gly Val Val Lys Ala Tyr Thr Thr Arg 
    290                 295                 300                 


Val Gly Ile Gly Ala Phe Pro Thr Glu Gln Ile Asn Glu Ile Gly Gly 
305                 310                 315                 320 


Leu Leu Gln Thr Arg Gly His Glu Trp Gly Val Thr Thr Gly Arg Lys 
                325                 330                 335     


Arg Arg Cys Gly Trp Leu Asp Leu Met Ile Leu Arg Tyr Ala His Met 
            340                 345                 350         


Val Asn Gly Phe Thr Ala Leu Ala Leu Thr Lys Leu Asp Ile Leu Asp 
        355                 360                 365             


Val Leu Gly Glu Val Lys Val Gly Val Ser Tyr Lys Leu Asn Gly Lys 
    370                 375                 380                 


Arg Ile Pro Tyr Phe Pro Ala Asn Gln Glu Met Leu Gln Lys Val Glu 
385                 390                 395                 400 


Val Glu Tyr Glu Thr Leu Pro Gly Trp Lys Ala Asp Thr Thr Gly Ala 
                405                 410                 415     


Arg Arg Trp Glu Asp Leu Pro Pro Gln Ala Gln Asn Tyr Ile Arg Phe 
            420                 425                 430         


Val Glu Asn His Val Gly Val Ala Val Lys Trp Val Gly Val Gly Lys 
        435                 440                 445             


Ser Arg Glu Ser Met Ile Gln Leu Phe 
    450                 455         


<210>  315
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADTRP__Homo_sapiens__NP_001137420

<400>  315

Met Thr Lys Thr Ser Thr Cys Ile Tyr His Phe Leu Val Leu Ser Trp 
1               5                   10                  15      


Tyr Thr Phe Leu Asn Tyr Tyr Ile Ser Gln Glu Gly Lys Asp Glu Val 
            20                  25                  30          


Lys Pro Lys Ile Leu Ala Asn Gly Ala Arg Trp Lys Tyr Met Thr Leu 
        35                  40                  45              


Leu Asn Leu Leu Lys Asn Arg Thr Ala Gly Phe Asp Ile Tyr Gln Pro 
    50                  55                  60                  


Gly Ser Phe Arg Gln Leu Leu Gln Thr Ile Phe Tyr Gly Val Thr Cys 
65                  70                  75                  80  


Leu Asp Asp Val Leu Lys Arg Thr Lys Gly Gly Lys Asp Ile Lys Phe 
                85                  90                  95      


Leu Thr Ala Phe Arg Asp Leu Leu Phe Thr Thr Leu Ala Phe Pro Val 
            100                 105                 110         


Ser Thr Phe Val Phe Leu Ala Phe Trp Ile Leu Phe Leu Tyr Asn Arg 
        115                 120                 125             


Asp Leu Ile Tyr Pro Lys Val Leu Asp Thr Val Ile Pro Val Trp Leu 
    130                 135                 140                 


Asn His Ala Met His Thr Phe Ile Phe Pro Ile Thr Leu Ala Glu Val 
145                 150                 155                 160 


Val Leu Arg Pro His Ser Tyr Pro Ser Lys Lys Thr Gly Leu Thr Leu 
                165                 170                 175     


Leu Ala Ala Ala Ser Ile Ala Tyr Ile Ser Arg Ile Leu Trp Leu Tyr 
            180                 185                 190         


Phe Glu Thr Gly Thr Trp Val Tyr Pro Val Phe Ala Lys Leu Ser Leu 
        195                 200                 205             


Leu Gly Leu Ala Ala Phe Phe Ser Leu Ser Tyr Val Phe Ile Ala Ser 
    210                 215                 220                 


Ile Tyr Leu Leu Gly Glu Lys Leu Asn His Trp Lys Trp Gly Asp Met 
225                 230                 235                 240 


Arg Gln Pro Arg Lys Lys Arg Lys 
                245             


<210>  316
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AEBP2__Homo_sapiens__NP_001107648

<400>  316

Met Ala Ala Ala Ile Thr Asp Met Ala Asp Leu Glu Glu Leu Ser Arg 
1               5                   10                  15      


Leu Ser Pro Leu Pro Pro Gly Ser Pro Gly Ser Ala Ala Arg Gly Arg 
            20                  25                  30          


Ala Glu Pro Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Ala Glu Ala Glu Ala Val Ala Ala Leu Leu Leu Asn Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Gly Gly Gly Glu Ala Glu 
65                  70                  75                  80  


Thr Met Ser Glu Pro Ser Pro Glu Ser Ala Ser Gln Ala Gly Glu Asp 
                85                  90                  95      


Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Glu Asp Glu Ser Ser Ser 
            100                 105                 110         


Ser Gly Gly Gly Glu Glu Glu Ser Ser Ala Glu Ser Leu Val Gly Ser 
        115                 120                 125             


Ser Gly Gly Ser Ser Ser Asp Glu Thr Arg Ser Leu Ser Pro Gly Ala 
    130                 135                 140                 


Ala Ser Ser Ser Ser Gly Asp Gly Asp Gly Lys Glu Gly Leu Glu Glu 
145                 150                 155                 160 


Pro Lys Gly Pro Arg Gly Ser Gln Gly Gly Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Ser Ser Ser Val Val Ser Ser Gly Gly Asp Glu Gly Tyr Gly Thr Gly 
            180                 185                 190         


Gly Gly Gly Ser Ser Ala Thr Ser Gly Gly Arg Arg Gly Ser Leu Glu 
        195                 200                 205             


Met Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp Ser Glu Asp Ser 
    210                 215                 220                 


Ile Ser Ser Thr Ile Met Asp Val Asp Ser Thr Ile Ser Ser Gly Arg 
225                 230                 235                 240 


Ser Thr Pro Ala Met Met Asn Gly Gln Gly Ser Thr Thr Ser Ser Ser 
                245                 250                 255     


Lys Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe 
            260                 265                 270         


Asn Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser Ile His Val Asp 
        275                 280                 285             


Gly Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val 
    290                 295                 300                 


Tyr Asn Thr Pro Ser Thr Ser Gln Ser Trp Leu Gln Arg His Met Leu 
305                 310                 315                 320 


Thr His Ser Gly Asp Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn 
                325                 330                 335     


Ala Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His Val Pro Thr His 
            340                 345                 350         


Phe Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln Pro Lys Ala Lys 
        355                 360                 365             


Glu Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg Arg Lys Leu Lys 
    370                 375                 380                 


Asn Lys Arg Arg Arg Ser Leu Pro Arg Pro His Asp Phe Phe Asp Ala 
385                 390                 395                 400 


Gln Thr Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser 
                405                 410                 415     


Ala His Ile Glu Ser Leu Gly Lys Gly His Ser Val Val Phe His Ser 
            420                 425                 430         


Thr Val Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu 
        435                 440                 445             


Leu His Trp Met Pro Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu 
    450                 455                 460                 


Ser Glu Arg His Gln Leu Lys Thr Lys Val Val His Leu Ser Lys Leu 
465                 470                 475                 480 


Pro Lys Asp Thr Ala Leu Leu Leu Asp Pro Asn Ile Tyr Arg Thr Met 
                485                 490                 495     


Pro Gln Lys Arg Leu Lys Arg Thr Leu Ile Arg Lys Val Phe Asn Leu 
            500                 505                 510         


Tyr Leu Ser Lys Gln 
        515         


<210>  317
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AEN__Homo_sapiens__NP_073604

<400>  317

Met Val Pro Arg Glu Ala Pro Glu Ser Ala Gln Cys Leu Cys Pro Ser 
1               5                   10                  15      


Leu Thr Ile Pro Asn Ala Lys Asp Val Leu Arg Lys Arg His Lys Arg 
            20                  25                  30          


Arg Ser Arg Gln His Gln Arg Phe Met Ala Arg Lys Ala Leu Leu Gln 
        35                  40                  45              


Glu Gln Gly Leu Leu Ser Met Pro Pro Glu Pro Gly Ser Ser Pro Leu 
    50                  55                  60                  


Pro Thr Pro Phe Gly Ala Ala Thr Ala Thr Glu Ala Ala Ser Ser Gly 
65                  70                  75                  80  


Lys Gln Cys Leu Arg Ala Gly Ser Gly Ser Ala Pro Cys Ser Arg Arg 
                85                  90                  95      


Pro Ala Pro Gly Lys Ala Ser Gly Pro Leu Pro Ser Lys Cys Val Ala 
            100                 105                 110         


Ile Asp Cys Glu Met Val Gly Thr Gly Pro Arg Gly Arg Val Ser Glu 
        115                 120                 125             


Leu Ala Arg Cys Ser Ile Val Ser Tyr His Gly Asn Val Leu Tyr Asp 
    130                 135                 140                 


Lys Tyr Ile Arg Pro Glu Met Pro Ile Ala Asp Tyr Arg Thr Arg Trp 
145                 150                 155                 160 


Ser Gly Ile Thr Arg Gln His Met Arg Lys Ala Val Pro Phe Gln Val 
                165                 170                 175     


Ala Gln Lys Glu Ile Leu Lys Leu Leu Lys Gly Lys Val Val Val Gly 
            180                 185                 190         


His Ala Leu His Asn Asp Phe Gln Ala Leu Lys Tyr Val His Pro Arg 
        195                 200                 205             


Ser Gln Thr Arg Asp Thr Thr Tyr Val Pro Asn Phe Leu Ser Glu Pro 
    210                 215                 220                 


Gly Leu His Thr Arg Ala Arg Val Ser Leu Lys Asp Leu Ala Leu Gln 
225                 230                 235                 240 


Leu Leu His Lys Lys Ile Gln Val Gly Gln His Gly His Ser Ser Val 
                245                 250                 255     


Glu Asp Ala Thr Thr Ala Met Glu Leu Tyr Arg Leu Val Glu Val Gln 
            260                 265                 270         


Trp Glu Gln Gln Glu Ala Arg Ser Leu Trp Thr Cys Pro Glu Asp Arg 
        275                 280                 285             


Glu Pro Asp Ser Ser Thr Asp Met Glu Gln Tyr Met Glu Asp Gln Tyr 
    290                 295                 300                 


Trp Pro Asp Asp Leu Ala His Gly Ser Arg Gly Gly Ala Arg Glu Ala 
305                 310                 315                 320 


Gln Asp Arg Arg Asn 
                325 


<210>  318
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AES__Homo_sapiens__NP_945320

<400>  318

Met Cys His Lys Asn Gly Phe Pro Gln Glu Gly Gly Ile Thr Ala Ala 
1               5                   10                  15      


Phe Leu Gln Lys Arg Lys Leu Arg Leu Ser Lys Asn His Arg Pro Ala 
            20                  25                  30          


Arg Ala Lys Val Thr Glu His Val Arg Gly Thr Arg Pro Gly Arg Ala 
        35                  40                  45              


Thr Ala Gly Pro Ala Ala Ser Thr Arg Ala Ala Gly Ser Leu Phe Phe 
    50                  55                  60                  


Asp Arg Trp Gly Asn Arg Gly Pro Ala Gly Cys Arg Gly Ser Ser His 
65                  70                  75                  80  


Leu Pro Gln Gln Leu Lys Phe Thr Thr Ser Asp Ser Cys Asp Arg Ile 
                85                  90                  95      


Lys Asp Glu Phe Gln Leu Leu Gln Ala Gln Tyr His Ser Leu Lys Leu 
            100                 105                 110         


Glu Cys Asp Lys Leu Ala Ser Glu Lys Ser Glu Met Gln Arg His Tyr 
        115                 120                 125             


Val Met Tyr Tyr Glu Met Ser Tyr Gly Leu Asn Ile Glu Met His Lys 
    130                 135                 140                 


Gln Ala Glu Ile Val Lys Arg Leu Asn Gly Ile Cys Ala Gln Val Leu 
145                 150                 155                 160 


Pro Tyr Leu Ser Gln Glu His Gln Gln Gln Val Leu Gly Ala Ile Glu 
                165                 170                 175     


Arg Ala Lys Gln Val Thr Ala Pro Glu Leu Asn Ser Ile Ile Arg Gln 
            180                 185                 190         


Gln Leu Gln Ala His Gln Leu Ser Gln Leu Gln Ala Leu Ala Leu Pro 
        195                 200                 205             


Leu Thr Pro Leu Pro Val Gly Leu Gln Pro Pro Ser Leu Pro Ala Val 
    210                 215                 220                 


Ser Ala Gly Thr Gly Leu Leu Ser Leu Ser Ala Leu Gly Ser Gln Ala 
225                 230                 235                 240 


His Leu Ser Lys Glu Asp Lys Asn Gly His Asp Gly Asp Thr His Gln 
                245                 250                 255     


Glu Asp Asp Gly Glu Lys Ser Asp 
            260                 


<210>  319
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFAP1__Homo_sapiens__NP_001128119

<400>  319

Met Glu Glu Leu Ile Val Glu Leu Arg Leu Phe Leu Glu Leu Leu Asp 
1               5                   10                  15      


His Glu Tyr Leu Thr Ser Thr Val Arg Glu Lys Lys Ala Val Ile Thr 
            20                  25                  30          


Asn Ile Leu Leu Arg Ile Gln Ser Ser Lys Gly Phe Asp Val Lys Asp 
        35                  40                  45              


His Ala Gln Lys Gln Glu Thr Ala Asn Ser Leu Pro Ala Pro Pro Gln 
    50                  55                  60                  


Met Pro Leu Pro Glu Ile Pro Gln Pro Trp Leu Pro Pro Asp Ser Gly 
65                  70                  75                  80  


Pro Pro Pro Leu Pro Thr Ser Ser Leu Pro Glu Gly Tyr Tyr Glu Glu 
                85                  90                  95      


Ala Val Pro Leu Ser Pro Gly Lys Ala Pro Glu Tyr Ile Thr Ser Asn 
            100                 105                 110         


Tyr Asp Ser Asp Ala Met Ser Ser Ser Tyr Glu Ser Tyr Asp Glu Glu 
        115                 120                 125             


Glu Glu Asp Gly Lys Gly Lys Lys Thr Arg His Gln Trp Pro Ser Glu 
    130                 135                 140                 


Glu Ala Ser Met Asp Leu Val Lys Asp Ala Lys Ile Cys Ala Phe Leu 
145                 150                 155                 160 


Leu Arg Lys Lys Arg Phe Gly Gln Trp Thr Lys Leu Leu Cys Val Ile 
                165                 170                 175     


Lys Asp Thr Lys Leu Leu Cys Tyr Lys Ser Ser Lys Asp Gln Gln Pro 
            180                 185                 190         


Gln Met Glu Leu Pro Leu Gln Gly Cys Asn Ile Thr Tyr Ile Pro Lys 
        195                 200                 205             


Asp Ser Lys Lys Lys Lys His Glu Leu Lys Ile Thr Gln Gln Gly Thr 
    210                 215                 220                 


Asp Pro Leu Val Leu Ala Val Gln Ser Lys Glu Gln Ala Glu Gln Trp 
225                 230                 235                 240 


Leu Lys Val Ile Lys Glu Ala Tyr Ser Gly Cys Ser Gly Pro Val Asp 
                245                 250                 255     


Ser Glu Cys Pro Pro Pro Pro Ser Ser Pro Val His Lys Ala Glu Leu 
            260                 265                 270         


Glu Lys Lys Leu Ser Ser Glu Arg Pro Ser Ser Asp Gly Glu Gly Val 
        275                 280                 285             


Val Glu Asn Gly Ile Thr Thr Cys Asn Gly Lys Glu Gln Val Lys Arg 
    290                 295                 300                 


Lys Lys Ser Ser Lys Ser Glu Ala Lys Gly Thr Val Ser Lys Val Thr 
305                 310                 315                 320 


Gly Lys Lys Ile Thr Lys Ile Ile Ser Leu Gly Lys Lys Lys Pro Ser 
                325                 330                 335     


Thr Asp Glu Gln Thr Ser Ser Ala Glu Glu Asp Val Pro Thr Cys Gly 
            340                 345                 350         


Tyr Leu Asn Val Leu Ser Asn Ser Arg Trp Arg Glu Arg Trp Cys Arg 
        355                 360                 365             


Val Lys Asp Asn Lys Leu Ile Phe His Lys Asp Arg Thr Asp Leu Lys 
    370                 375                 380                 


Thr His Ile Val Ser Ile Pro Leu Arg Gly Cys Glu Val Ile Pro Gly 
385                 390                 395                 400 


Leu Asp Ser Lys His Pro Leu Thr Phe Arg Leu Leu Arg Asn Gly Gln 
                405                 410                 415     


Glu Val Ala Val Leu Glu Ala Ser Ser Ser Glu Asp Met Gly Arg Trp 
            420                 425                 430         


Ile Gly Ile Leu Leu Ala Glu Thr Gly Ser Ser Thr Asp Pro Glu Ala 
        435                 440                 445             


Leu His Tyr Asp Tyr Ile Asp Val Glu Met Ser Ala Ser Val Ile Gln 
    450                 455                 460                 


Thr Ala Lys Gln Thr Phe Cys Phe Met Asn Arg Arg Val Ile Ser Ala 
465                 470                 475                 480 


Asn Pro Tyr Leu Gly Gly Thr Ser Asn Gly Tyr Ala His Pro Ser Gly 
                485                 490                 495     


Thr Ala Leu His Tyr Asp Asp Val Pro Cys Ile Asn Gly Ser Trp Glu 
            500                 505                 510         


Pro Glu Asp Gly Phe Pro Ala Ser Cys Ser Arg Gly Leu Gly Glu Glu 
        515                 520                 525             


Val Leu Tyr Asp Asn Ala Gly Leu Tyr Asp Asn Leu Pro Pro Pro His 
    530                 535                 540                 


Ile Phe Ala Arg Tyr Ser Pro Ala Asp Arg Lys Ala Ser Arg Leu Ser 
545                 550                 555                 560 


Ala Asp Lys Leu Ser Ser Asn His Tyr Lys Tyr Pro Ala Ser Ala Gln 
                565                 570                 575     


Ser Val Thr Asn Thr Ser Ser Val Gly Arg Ala Ser Leu Gly Leu Asn 
            580                 585                 590         


Ser Gln Leu Lys Gly Lys Lys Pro Pro Val Ala Ser Asn Gly Val Thr 
        595                 600                 605             


Gly Lys Gly Lys Thr Leu Ser Ser Gln Pro Lys Lys Ala Asp Pro Ala 
    610                 615                 620                 


Ala Val Val Lys Arg Thr Gly Ser Asn Ala Ala Gln Tyr Lys Tyr Gly 
625                 630                 635                 640 


Lys Asn Arg Val Glu Ala Asp Ala Lys Arg Leu Gln Thr Lys Glu Glu 
                645                 650                 655     


Glu Leu Leu Lys Arg Lys Glu Ala Leu Arg Asn Arg Leu Ala Gln Leu 
            660                 665                 670         


Arg Lys Glu Arg Lys Asp Leu Arg Ala Ala Ile Glu Val Asn Ala Gly 
        675                 680                 685             


Arg Lys Pro Gln Ala Ile Leu Glu Glu Lys Leu Lys Gln Leu Glu Glu 
    690                 695                 700                 


Glu Cys Arg Gln Lys Glu Ala Glu Arg Val Ser Leu Glu Leu Glu Leu 
705                 710                 715                 720 


Thr Glu Val Lys Glu Ser Leu Lys Lys Ala Leu Ala Gly Gly Val Thr 
                725                 730                 735     


Leu Gly Leu Ala Ile Glu Pro Lys Ser Gly Thr Ser Ser Pro Gln Ser 
            740                 745                 750         


Pro Val Phe Arg His Arg Thr Leu Glu Asn Ser Pro Ile Ser Ser Cys 
        755                 760                 765             


Asp Thr Ser Asp Thr Glu Gly Pro Val Pro Val Asn Ser Ala Ala Val 
    770                 775                 780                 


Leu Lys Lys Ser Gln Ala Ala Pro Gly Ser Ser Pro Cys Arg Gly His 
785                 790                 795                 800 


Val Leu Arg Lys Ala Lys Glu Trp Glu Leu Lys Asn Gly Thr 
                805                 810                 


<210>  320
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFAP1L1__Homo_sapiens__NP_001139809

<400>  320

Met Asp Arg Gly Gln Val Leu Glu Gln Leu Leu Pro Glu Leu Thr Gly 
1               5                   10                  15      


Leu Leu Ser Leu Leu Asp His Glu Tyr Leu Ser Asp Thr Thr Leu Glu 
            20                  25                  30          


Lys Lys Met Ala Val Ala Ser Ile Leu Gln Ser Leu Gln Pro Leu Pro 
        35                  40                  45              


Ala Lys Glu Val Ser Tyr Leu Tyr Val Asn Thr Ala Asp Leu His Ser 
    50                  55                  60                  


Gly Pro Ser Phe Val Glu Ser Leu Phe Glu Glu Phe Asp Cys Asp Leu 
65                  70                  75                  80  


Ser Asp Leu Arg Asp Met Pro Glu Asp Asp Gly Glu Pro Ser Lys Gly 
                85                  90                  95      


Ala Ser Pro Glu Leu Ala Lys Ser Pro Arg Leu Arg Asn Ala Ala Asp 
            100                 105                 110         


Leu Pro Pro Pro Leu Pro Asn Lys Pro Pro Pro Glu Asp Tyr Tyr Glu 
        115                 120                 125             


Glu Ala Leu Pro Leu Gly Pro Gly Lys Ser Pro Glu Tyr Ile Ser Ser 
    130                 135                 140                 


His Asn Gly Cys Ser Pro Ser His Ser Ile Val Asp Gly Tyr Tyr Glu 
145                 150                 155                 160 


Asp Ala Asp Ser Ser Tyr Pro Ala Thr Arg Val Asn Gly Glu Leu Lys 
                165                 170                 175     


Ser Ser Tyr Asn Asp Ser Asp Ala Met Ser Ser Ser Tyr Glu Ser Tyr 
            180                 185                 190         


Asp Glu Glu Glu Glu Glu Gly Lys Ser Pro Gln Pro Arg His Gln Trp 
        195                 200                 205             


Pro Ser Glu Glu Ala Ser Met His Leu Val Arg Glu Cys Arg Ile Cys 
    210                 215                 220                 


Ala Phe Leu Leu Arg Lys Lys Arg Phe Gly Gln Trp Ala Lys Gln Leu 
225                 230                 235                 240 


Thr Val Ile Arg Glu Asp Gln Leu Leu Cys Tyr Lys Ser Ser Lys Asp 
                245                 250                 255     


Arg Gln Pro His Leu Arg Leu Ala Leu Asp Thr Cys Ser Ile Ile Tyr 
            260                 265                 270         


Val Pro Lys Asp Ser Arg His Lys Arg His Glu Leu Arg Phe Thr Gln 
        275                 280                 285             


Gly Ala Thr Glu Val Leu Val Leu Ala Leu Gln Ser Arg Glu Gln Ala 
    290                 295                 300                 


Glu Glu Trp Leu Lys Val Ile Arg Glu Val Ser Lys Pro Val Gly Gly 
305                 310                 315                 320 


Ala Glu Gly Val Glu Val Pro Arg Ser Pro Val Leu Leu Cys Lys Leu 
                325                 330                 335     


Asp Leu Asp Lys Arg Leu Ser Gln Glu Lys Gln Thr Ser Asp Ser Asp 
            340                 345                 350         


Ser Val Gly Val Gly Asp Asn Cys Ser Thr Leu Gly Arg Arg Glu Thr 
        355                 360                 365             


Cys Asp His Gly Lys Gly Lys Lys Ser Ser Leu Ala Glu Leu Lys Gly 
    370                 375                 380                 


Ser Met Ser Arg Ala Ala Gly Arg Lys Ile Thr Arg Ile Ile Gly Phe 
385                 390                 395                 400 


Ser Lys Lys Lys Thr Leu Ala Asp Asp Leu Gln Thr Ser Ser Thr Glu 
                405                 410                 415     


Glu Glu Val Pro Cys Cys Gly Tyr Leu Asn Val Leu Val Asn Gln Gly 
            420                 425                 430         


Trp Lys Glu Arg Trp Cys Arg Leu Lys Cys Asn Thr Leu Tyr Phe His 
        435                 440                 445             


Lys Asp His Met Asp Leu Arg Thr His Val Asn Ala Ile Ala Leu Gln 
    450                 455                 460                 


Gly Cys Glu Val Ala Pro Gly Phe Gly Pro Arg His Pro Phe Ala Phe 
465                 470                 475                 480 


Arg Ile Leu Arg Asn Arg Gln Glu Val Ala Ile Leu Glu Ala Ser Cys 
                485                 490                 495     


Ser Glu Asp Met Gly Arg Trp Leu Gly Leu Leu Leu Val Glu Met Gly 
            500                 505                 510         


Ser Arg Val Thr Pro Glu Ala Leu His Tyr Asp Tyr Val Asp Val Glu 
        515                 520                 525             


Thr Leu Thr Ser Ile Val Ser Ala Gly Arg Asn Ser Phe Leu Tyr Ala 
    530                 535                 540                 


Arg Ser Cys Gln Asn Gln Trp Pro Glu Pro Arg Val Tyr Asp Asp Val 
545                 550                 555                 560 


Pro Tyr Glu Lys Met Gln Asp Glu Glu Pro Glu Arg Pro Thr Gly Ala 
                565                 570                 575     


Gln Val Lys Arg His Ala Ser Ser Cys Ser Glu Lys Ser His Arg Val 
            580                 585                 590         


Asp Pro Gln Val Lys Val Lys Arg His Ala Ser Ser Ala Asn Gln Tyr 
        595                 600                 605             


Lys Tyr Gly Lys Asn Arg Ala Glu Glu Asp Ala Arg Arg Tyr Leu Val 
    610                 615                 620                 


Glu Lys Glu Lys Leu Glu Lys Glu Lys Glu Thr Ile Arg Thr Glu Leu 
625                 630                 635                 640 


Ile Ala Leu Arg Gln Glu Lys Arg Glu Leu Lys Glu Ala Ile Arg Ser 
                645                 650                 655     


Ser Pro Gly Ala Lys Leu Lys Ala Leu Glu Glu Ala Val Ala Thr Leu 
            660                 665                 670         


Glu Ala Gln Cys Arg Ala Lys Glu Glu Arg Arg Ile Asp Leu Glu Leu 
        675                 680                 685             


Lys Leu Val Ala Val Lys Glu Arg Leu Gln Gln Ser Leu Ala Gly Gly 
    690                 695                 700                 


Pro Ala Leu Gly Leu Ser Val Ser Ser Lys Pro Lys Ser Gly Glu Trp 
705                 710                 715                 720 


Glu Met Lys Lys Thr 
                725 


<210>  321
<211>  818
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFAP1L2__Homo_sapiens__NP_001001936

<400>  321

Met Glu Arg Tyr Lys Ala Leu Glu Gln Leu Leu Thr Glu Leu Asp Asp 
1               5                   10                  15      


Phe Leu Lys Ile Leu Asp Gln Glu Asn Leu Ser Ser Thr Ala Leu Val 
            20                  25                  30          


Lys Lys Ser Cys Leu Ala Glu Leu Leu Arg Leu Tyr Thr Lys Ser Ser 
        35                  40                  45              


Ser Ser Asp Glu Glu Tyr Ile Tyr Met Asn Lys Val Thr Ile Asn Lys 
    50                  55                  60                  


Gln Gln Asn Ala Glu Ser Gln Gly Lys Ala Pro Glu Glu Gln Gly Leu 
65                  70                  75                  80  


Leu Pro Asn Gly Glu Pro Ser Gln His Ser Ser Ala Pro Gln Lys Ser 
                85                  90                  95      


Leu Pro Asp Leu Pro Pro Pro Lys Met Ile Pro Glu Arg Lys Gln Leu 
            100                 105                 110         


Ala Ile Pro Lys Thr Glu Ser Pro Glu Gly Tyr Tyr Glu Glu Ala Glu 
        115                 120                 125             


Pro Tyr Asp Thr Ser Leu Asn Glu Asp Gly Glu Ala Val Ser Ser Ser 
    130                 135                 140                 


Tyr Glu Ser Tyr Asp Glu Glu Asp Gly Ser Lys Gly Lys Ser Ala Pro 
145                 150                 155                 160 


Tyr Gln Trp Pro Ser Pro Glu Ala Gly Ile Glu Leu Met Arg Asp Ala 
                165                 170                 175     


Arg Ile Cys Ala Phe Leu Trp Arg Lys Lys Trp Leu Gly Gln Trp Ala 
            180                 185                 190         


Lys Gln Leu Cys Val Ile Lys Asp Asn Arg Leu Leu Cys Tyr Lys Ser 
        195                 200                 205             


Ser Lys Asp His Ser Pro Gln Leu Asp Val Asn Leu Leu Gly Ser Ser 
    210                 215                 220                 


Val Ile His Lys Glu Lys Gln Val Arg Lys Lys Glu His Lys Leu Lys 
225                 230                 235                 240 


Ile Thr Pro Met Asn Ala Asp Val Ile Val Leu Gly Leu Gln Ser Lys 
                245                 250                 255     


Asp Gln Ala Glu Gln Trp Leu Arg Val Ile Gln Glu Val Ser Gly Leu 
            260                 265                 270         


Pro Ser Glu Gly Ala Ser Glu Gly Asn Gln Tyr Thr Pro Asp Ala Gln 
        275                 280                 285             


Arg Phe Asn Cys Gln Lys Pro Asp Ile Ala Glu Lys Tyr Leu Ser Ala 
    290                 295                 300                 


Ser Glu Tyr Gly Ser Ser Val Asp Gly His Pro Glu Val Pro Glu Thr 
305                 310                 315                 320 


Lys Asp Val Lys Lys Lys Cys Ser Ala Gly Leu Lys Leu Ser Asn Leu 
                325                 330                 335     


Met Asn Leu Gly Arg Lys Lys Ser Thr Ser Leu Glu Pro Val Glu Arg 
            340                 345                 350         


Ser Leu Glu Thr Ser Ser Tyr Leu Asn Val Leu Val Asn Ser Gln Trp 
        355                 360                 365             


Lys Ser Arg Trp Cys Ser Val Arg Asp Asn His Leu His Phe Tyr Gln 
    370                 375                 380                 


Asp Arg Asn Arg Ser Lys Val Ala Gln Gln Pro Leu Ser Leu Val Gly 
385                 390                 395                 400 


Cys Glu Val Val Pro Asp Pro Ser Pro Asp His Leu Tyr Ser Phe Arg 
                405                 410                 415     


Ile Leu His Lys Gly Glu Glu Leu Ala Lys Leu Glu Ala Lys Ser Ser 
            420                 425                 430         


Glu Glu Met Gly His Trp Leu Gly Leu Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Lys Thr Asp Pro Glu Glu Phe Thr Tyr Asp Tyr Val Asp Ala Asp Arg 
    450                 455                 460                 


Val Ser Cys Ile Val Ser Ala Ala Lys Asn Ser Leu Leu Leu Met Gln 
465                 470                 475                 480 


Arg Lys Phe Ser Glu Pro Asn Thr Tyr Ile Asp Gly Leu Pro Ser Gln 
                485                 490                 495     


Asp Arg Gln Glu Glu Leu Tyr Asp Asp Val Asp Leu Ser Glu Leu Thr 
            500                 505                 510         


Ala Ala Val Glu Pro Thr Glu Glu Ala Thr Pro Val Ala Asp Asp Pro 
        515                 520                 525             


Asn Glu Arg Glu Ser Asp Arg Val Tyr Leu Asp Leu Thr Pro Val Lys 
    530                 535                 540                 


Ser Phe Leu His Gly Pro Ser Ser Ala Gln Ala Gln Ala Ser Ser Pro 
545                 550                 555                 560 


Thr Leu Ser Cys Leu Asp Asn Ala Thr Glu Ala Leu Pro Ala Asp Ser 
                565                 570                 575     


Gly Pro Gly Pro Thr Pro Asp Glu Pro Cys Ile Lys Cys Pro Glu Asn 
            580                 585                 590         


Leu Gly Glu Gln Gln Leu Glu Ser Leu Glu Pro Glu Asp Pro Ser Leu 
        595                 600                 605             


Arg Ile Thr Thr Val Lys Ile Gln Thr Glu Gln Gln Arg Ile Ser Phe 
    610                 615                 620                 


Pro Pro Ser Cys Pro Asp Ala Val Val Ala Thr Pro Pro Gly Ala Ser 
625                 630                 635                 640 


Pro Pro Val Lys Asp Arg Leu Arg Val Thr Ser Ala Glu Ile Lys Leu 
                645                 650                 655     


Gly Lys Asn Arg Thr Glu Ala Glu Val Lys Arg Tyr Thr Glu Glu Lys 
            660                 665                 670         


Glu Arg Leu Glu Lys Lys Lys Glu Glu Ile Arg Gly His Leu Ala Gln 
        675                 680                 685             


Leu Arg Lys Glu Lys Arg Glu Leu Lys Glu Thr Leu Leu Lys Cys Thr 
    690                 695                 700                 


Asp Lys Glu Val Leu Ala Ser Leu Glu Gln Lys Leu Lys Glu Ile Asp 
705                 710                 715                 720 


Glu Glu Cys Arg Gly Glu Glu Ser Arg Arg Val Asp Leu Glu Leu Ser 
                725                 730                 735     


Ile Met Glu Val Lys Asp Asn Leu Lys Lys Ala Glu Ala Gly Pro Val 
            740                 745                 750         


Thr Leu Gly Thr Thr Val Asp Thr Thr His Leu Glu Asn Val Ser Pro 
        755                 760                 765             


Arg Pro Lys Ala Val Thr Pro Ala Ser Ala Pro Asp Cys Thr Pro Val 
    770                 775                 780                 


Asn Ser Ala Thr Thr Leu Lys Asn Arg Pro Leu Ser Val Val Val Thr 
785                 790                 795                 800 


Gly Lys Gly Thr Val Leu Gln Lys Ala Lys Glu Trp Glu Lys Lys Gly 
                805                 810                 815     


Ala Ser 
        


<210>  322
<211>  1218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFF1__Homo_sapiens__NP_001160165

<400>  322

Met Ala Phe Thr Glu Arg Val Asn Ser Ser Gly Asn Ser Leu Tyr Asn 
1               5                   10                  15      


Asp Asp Arg Asn Leu Leu Arg Ile Arg Glu Lys Glu Arg Arg Asn Gln 
            20                  25                  30          


Glu Ala His Gln Glu Lys Glu Ala Phe Pro Glu Lys Ile Pro Leu Phe 
        35                  40                  45              


Gly Glu Pro Tyr Lys Thr Ala Lys Gly Asp Glu Leu Ser Ser Arg Ile 
    50                  55                  60                  


Gln Asn Met Leu Gly Asn Tyr Glu Glu Val Lys Glu Phe Leu Ser Thr 
65                  70                  75                  80  


Lys Ser His Thr His Arg Leu Asp Ala Ser Glu Asn Arg Leu Gly Lys 
                85                  90                  95      


Pro Lys Tyr Pro Leu Ile Pro Asp Lys Gly Ser Ser Ile Pro Ser Ser 
            100                 105                 110         


Ser Phe His Thr Ser Val His His Gln Ser Ile His Thr Pro Ala Ser 
        115                 120                 125             


Gly Pro Leu Ser Val Gly Asn Ile Ser His Asn Pro Lys Met Ala Gln 
    130                 135                 140                 


Pro Arg Thr Glu Pro Met Pro Ser Leu His Ala Lys Ser Cys Gly Pro 
145                 150                 155                 160 


Pro Asp Ser Gln His Leu Thr Gln Asp Arg Leu Gly Gln Glu Gly Phe 
                165                 170                 175     


Gly Ser Ser His His Lys Lys Gly Asp Arg Arg Ala Asp Gly Asp His 
            180                 185                 190         


Cys Ala Ser Val Thr Asp Ser Ala Pro Glu Arg Glu Leu Ser Pro Leu 
        195                 200                 205             


Ile Ser Leu Pro Ser Pro Val Pro Pro Leu Ser Pro Ile His Ser Asn 
    210                 215                 220                 


Gln Gln Thr Leu Pro Arg Thr Gln Gly Ser Ser Lys Val His Gly Ser 
225                 230                 235                 240 


Ser Asn Asn Ser Lys Gly Tyr Cys Pro Ala Lys Ser Pro Lys Asp Leu 
                245                 250                 255     


Ala Val Lys Val His Asp Lys Glu Thr Pro Gln Asp Ser Leu Val Ala 
            260                 265                 270         


Pro Ala Gln Pro Pro Ser Gln Thr Phe Pro Pro Pro Ser Leu Pro Ser 
        275                 280                 285             


Lys Ser Val Ala Met Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met 
    290                 295                 300                 


Asp Gly Gln Asp Gln Ala Pro Ser Glu Ser Pro Glu Leu Lys Pro Leu 
305                 310                 315                 320 


Pro Glu Asp Tyr Arg Gln Gln Thr Phe Glu Lys Thr Asp Leu Lys Val 
                325                 330                 335     


Pro Ala Lys Ala Lys Leu Thr Lys Leu Lys Met Pro Ser Gln Ser Val 
            340                 345                 350         


Glu Gln Thr Tyr Ser Asn Glu Val His Cys Val Glu Glu Ile Leu Lys 
        355                 360                 365             


Glu Met Thr His Ser Trp Pro Pro Pro Leu Thr Ala Ile His Thr Pro 
    370                 375                 380                 


Ser Thr Ala Glu Pro Ser Lys Phe Pro Phe Pro Thr Lys Asp Ser Gln 
385                 390                 395                 400 


His Val Ser Ser Val Thr Gln Asn Gln Lys Gln Tyr Asp Thr Ser Ser 
                405                 410                 415     


Lys Thr His Ser Asn Ser Gln Gln Gly Thr Ser Ser Met Leu Glu Asp 
            420                 425                 430         


Asp Leu Gln Leu Ser Asp Ser Glu Asp Ser Asp Ser Glu Gln Thr Pro 
        435                 440                 445             


Glu Lys Pro Pro Ser Ser Ser Ala Pro Pro Ser Ala Pro Gln Ser Leu 
    450                 455                 460                 


Pro Glu Pro Val Ala Ser Ala His Ser Ser Ser Ala Glu Ser Glu Ser 
465                 470                 475                 480 


Thr Ser Asp Ser Asp Ser Ser Ser Asp Ser Glu Ser Glu Ser Ser Ser 
                485                 490                 495     


Ser Asp Ser Glu Glu Asn Glu Pro Leu Glu Thr Pro Ala Pro Glu Pro 
            500                 505                 510         


Glu Pro Pro Thr Thr Asn Lys Trp Gln Leu Asp Asn Trp Leu Thr Lys 
        515                 520                 525             


Val Ser Gln Pro Ala Ala Pro Pro Glu Gly Pro Arg Ser Thr Glu Pro 
    530                 535                 540                 


Pro Arg Arg His Pro Glu Ser Lys Gly Ser Ser Asp Ser Ala Thr Ser 
545                 550                 555                 560 


Gln Glu His Ser Glu Ser Lys Asp Pro Pro Pro Lys Ser Ser Ser Lys 
                565                 570                 575     


Ala Pro Arg Ala Pro Pro Glu Ala Pro His Pro Gly Lys Arg Ser Cys 
            580                 585                 590         


Gln Lys Ser Pro Ala Gln Gln Glu Pro Pro Gln Arg Gln Thr Val Gly 
        595                 600                 605             


Thr Lys Gln Pro Lys Lys Pro Val Lys Ala Ser Ala Arg Ala Gly Ser 
    610                 615                 620                 


Arg Thr Ser Leu Gln Gly Glu Arg Glu Pro Gly Leu Leu Pro Tyr Gly 
625                 630                 635                 640 


Ser Arg Asp Gln Thr Ser Lys Asp Lys Pro Lys Val Lys Thr Lys Gly 
                645                 650                 655     


Arg Pro Arg Ala Ala Ala Ser Asn Glu Pro Lys Pro Ala Val Pro Pro 
            660                 665                 670         


Ser Ser Glu Lys Lys Lys His Lys Ser Ser Leu Pro Ala Pro Ser Lys 
        675                 680                 685             


Ala Leu Ser Gly Pro Glu Pro Ala Lys Asp Asn Val Glu Asp Arg Thr 
    690                 695                 700                 


Pro Glu His Phe Ala Leu Val Pro Leu Thr Glu Ser Gln Gly Pro Pro 
705                 710                 715                 720 


His Ser Gly Ser Gly Ser Arg Thr Ser Gly Cys Arg Gln Ala Val Val 
                725                 730                 735     


Val Gln Glu Asp Ser Arg Lys Asp Arg Leu Pro Leu Pro Leu Arg Asp 
            740                 745                 750         


Thr Lys Leu Leu Ser Pro Leu Arg Asp Thr Pro Pro Pro Gln Ser Leu 
        755                 760                 765             


Met Val Lys Ile Thr Leu Asp Leu Leu Ser Arg Ile Pro Gln Pro Pro 
    770                 775                 780                 


Gly Lys Gly Ser Arg Gln Arg Lys Ala Glu Asp Lys Gln Pro Pro Ala 
785                 790                 795                 800 


Gly Lys Lys His Ser Ser Glu Lys Arg Ser Ser Asp Ser Ser Ser Lys 
                805                 810                 815     


Leu Ala Lys Lys Arg Lys Gly Glu Ala Glu Arg Asp Cys Asp Asn Lys 
            820                 825                 830         


Lys Ile Arg Leu Glu Lys Glu Ile Lys Ser Gln Ser Ser Ser Ser Ser 
        835                 840                 845             


Ser Ser His Lys Glu Ser Ser Lys Thr Lys Pro Ser Arg Pro Ser Ser 
    850                 855                 860                 


Gln Ser Ser Lys Lys Glu Met Leu Pro Pro Pro Pro Val Ser Ser Ser 
865                 870                 875                 880 


Ser Gln Lys Pro Ala Lys Pro Ala Leu Lys Arg Ser Arg Arg Glu Ala 
                885                 890                 895     


Asp Thr Cys Gly Gln Asp Pro Pro Lys Ser Ala Ser Ser Thr Lys Ser 
            900                 905                 910         


Asn His Lys Asp Ser Ser Ile Pro Lys Gln Arg Arg Val Glu Gly Lys 
        915                 920                 925             


Gly Ser Arg Ser Ser Ser Glu His Lys Gly Ser Ser Gly Asp Thr Ala 
    930                 935                 940                 


Asn Pro Phe Pro Val Pro Ser Leu Pro Asn Gly Asn Ser Lys Pro Gly 
945                 950                 955                 960 


Lys Pro Gln Val Lys Phe Asp Lys Gln Gln Ala Asp Leu His Met Arg 
                965                 970                 975     


Glu Ala Lys Lys Met Lys Gln Lys Ala Glu Leu Met Thr Asp Arg Val 
            980                 985                 990         


Gly Lys Ala Phe Lys Tyr Leu Glu  Ala Val Leu Ser Phe  Ile Glu Cys 
        995                 1000                 1005             


Gly Ile  Ala Thr Glu Ser Glu  Ser Gln Ser Ser Lys  Ser Ala Tyr 
    1010                 1015                 1020             


Ser Val  Tyr Ser Glu Thr Val  Asp Leu Ile Lys Phe  Ile Met Ser 
    1025                 1030                 1035             


Leu Lys  Ser Phe Ser Asp Ala  Thr Ala Pro Thr Gln  Glu Lys Ile 
    1040                 1045                 1050             


Phe Ala  Val Leu Cys Met Arg  Cys Gln Ser Ile Leu  Asn Met Ala 
    1055                 1060                 1065             


Met Phe  Arg Cys Lys Lys Asp  Ile Ala Ile Lys Tyr  Ser Arg Thr 
    1070                 1075                 1080             


Leu Asn  Lys His Phe Glu Ser  Ser Ser Lys Val Ala  Gln Ala Pro 
    1085                 1090                 1095             


Ser Pro  Cys Ile Ala Arg Ser  Thr Gly Thr Pro Ser  Pro Leu Ser 
    1100                 1105                 1110             


Pro Met  Pro Ser Pro Ala Ser  Ser Val Gly Ser Gln  Ser Ser Ala 
    1115                 1120                 1125             


Gly Ser  Val Gly Ser Ser Gly  Val Ala Ala Thr Ile  Ser Thr Pro 
    1130                 1135                 1140             


Val Thr  Ile Gln Asn Met Thr  Ser Ser Tyr Val Thr  Ile Thr Ser 
    1145                 1150                 1155             


His Val  Leu Thr Ala Phe Asp  Leu Trp Glu Gln Ala  Glu Ala Leu 
    1160                 1165                 1170             


Thr Arg  Lys Asn Lys Glu Phe  Phe Ala Arg Leu Ser  Thr Asn Val 
    1175                 1180                 1185             


Cys Thr  Leu Ala Leu Asn Ser  Ser Leu Val Asp Leu  Val His Tyr 
    1190                 1195                 1200             


Thr Arg  Gln Gly Phe Gln Gln  Leu Gln Glu Leu Thr  Lys Thr Pro 
    1205                 1210                 1215             


<210>  323
<211>  1276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFF2__Homo_sapiens__NP_001162593

<400>  323

Met Asp Leu Phe Asp Phe Phe Arg Asp Trp Asp Leu Glu Gln Gln Cys 
1               5                   10                  15      


His Tyr Glu Gln Asp Arg Ser Ala Leu Lys Lys Arg Glu Trp Glu Arg 
            20                  25                  30          


Arg Asn Gln Glu Val Gln Gln Glu Asp Asp Leu Phe Ser Ser Gly Phe 
        35                  40                  45              


Asp Leu Phe Gly Glu Pro Tyr Lys Thr Asn Lys Gly Asp Ala Leu Ala 
    50                  55                  60                  


Asn Arg Val Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys Asn Leu 
65                  70                  75                  80  


Leu Thr Asn His Ser Asn Gln Asn His Leu Val Gly Ile Pro Lys Asn 
                85                  90                  95      


Ser Val Pro Gln Asn Pro Asn Asn Lys Asn Glu Pro Ser Phe Phe Pro 
            100                 105                 110         


Glu Gln Lys Asn Arg Ile Ile Pro Pro His Gln Asp Asn Thr His Pro 
        115                 120                 125             


Ser Ala Pro Met Pro Pro Pro Ser Val Val Ile Leu Asn Ser Thr Leu 
    130                 135                 140                 


Ile His Ser Asn Arg Lys Ser Lys Pro Glu Trp Ser Arg Asp Ser His 
145                 150                 155                 160 


Asn Pro Ser Thr Val Leu Ala Ser Gln Ala Ser Gly Gln Pro Asn Lys 
                165                 170                 175     


Met Gln Thr Leu Thr Gln Asp Gln Ser Gln Ala Lys Leu Glu Asp Phe 
            180                 185                 190         


Phe Val Tyr Pro Ala Glu Gln Pro Gln Ile Gly Glu Val Glu Glu Ser 
        195                 200                 205             


Asn Pro Ser Ala Lys Glu Asp Ser Asn Pro Asn Ser Ser Gly Glu Asp 
    210                 215                 220                 


Ala Phe Lys Glu Ile Phe Gln Ser Asn Ser Pro Glu Glu Ser Glu Phe 
225                 230                 235                 240 


Ala Val Gln Ala Pro Gly Ser Pro Leu Val Ala Ser Ser Leu Leu Ala 
                245                 250                 255     


Pro Ser Ser Gly Leu Ser Val Gln Asn Phe Pro Pro Gly Leu Tyr Cys 
            260                 265                 270         


Lys Thr Ser Met Gly Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met 
        275                 280                 285             


Asp Gly Gln Asp Gln Ala Pro Asp Ile Ser Pro Thr Leu Lys Pro Ser 
    290                 295                 300                 


Ile Glu Phe Glu Asn Ser Phe Gly Asn Leu Ser Phe Gly Thr Leu Leu 
305                 310                 315                 320 


Asp Gly Lys Pro Ser Ala Ala Ser Ser Lys Thr Lys Leu Pro Lys Phe 
                325                 330                 335     


Thr Ile Leu Gln Thr Ser Glu Val Ser Leu Pro Ser Asp Pro Ser Cys 
            340                 345                 350         


Val Glu Glu Ile Leu Arg Glu Ser Gln His Leu Thr Pro Gly Phe Thr 
        355                 360                 365             


Leu Gln Lys Trp Asn Asp Pro Thr Thr Arg Ala Ser Thr Lys Ser Val 
    370                 375                 380                 


Ser Phe Lys Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp Glu 
385                 390                 395                 400 


Asp Asp Leu Glu Pro Val Lys Thr Leu Thr Thr Gln Cys Thr Ala Thr 
                405                 410                 415     


Glu Leu Tyr Gln Ala Val Glu Lys Ala Lys Pro Arg Asn Asn Pro Val 
            420                 425                 430         


Asn Pro Pro Leu Ala Thr Pro Gln Pro Pro Pro Ala Val Gln Ala Ser 
        435                 440                 445             


Gly Gly Ser Gly Ser Ser Ser Glu Ser Glu Ser Ser Ser Glu Ser Asp 
    450                 455                 460                 


Ser Asp Thr Glu Ser Ser Thr Thr Asp Ser Glu Ser Asn Glu Ala Pro 
465                 470                 475                 480 


Arg Val Ala Thr Pro Glu Pro Glu Pro Pro Ser Thr Asn Lys Trp Gln 
                485                 490                 495     


Leu Asp Lys Trp Leu Asn Lys Val Thr Ser Gln Asn Lys Ser Phe Ile 
            500                 505                 510         


Cys Gly Gln Asn Glu Thr Pro Met Glu Thr Ile Ser Leu Pro Pro Pro 
        515                 520                 525             


Ile Ile Gln Pro Met Glu Val Gln Met Lys Val Lys Thr Asn Ala Ser 
    530                 535                 540                 


Gln Val Pro Ala Glu Pro Lys Glu Arg Pro Leu Leu Ser Leu Ile Arg 
545                 550                 555                 560 


Glu Lys Ala Arg Pro Arg Pro Thr Gln Lys Ile Pro Glu Thr Lys Ala 
                565                 570                 575     


Leu Lys His Lys Leu Ser Thr Thr Ser Glu Thr Val Ser Gln Arg Thr 
            580                 585                 590         


Ile Gly Lys Lys Gln Pro Lys Lys Val Glu Lys Asn Thr Ser Thr Asp 
        595                 600                 605             


Glu Phe Thr Trp Pro Lys Pro Asn Ile Thr Ser Ser Thr Pro Lys Glu 
    610                 615                 620                 


Lys Glu Ser Val Glu Leu His Asp Pro Pro Arg Gly Arg Asn Lys Ala 
625                 630                 635                 640 


Thr Ala His Lys Pro Ala Pro Arg Lys Glu Pro Arg Pro Asn Ile Pro 
                645                 650                 655     


Leu Ala Pro Glu Lys Lys Lys Tyr Arg Gly Pro Gly Lys Ile Val Pro 
            660                 665                 670         


Lys Ser Arg Glu Phe Ile Glu Thr Asp Ser Ser Thr Ser Asp Ser Asn 
        675                 680                 685             


Thr Asp Gln Glu Glu Thr Leu Gln Ile Lys Val Leu Pro Pro Cys Ile 
    690                 695                 700                 


Ile Ser Gly Gly Asn Thr Ala Lys Ser Lys Glu Ile Cys Gly Ala Ser 
705                 710                 715                 720 


Leu Thr Leu Ser Thr Leu Met Ser Ser Ser Gly Ser Asn Asn Asn Leu 
                725                 730                 735     


Ser Ile Ser Asn Glu Glu Pro Thr Phe Ser Pro Ile Pro Val Met Gln 
            740                 745                 750         


Thr Glu Ile Leu Ser Pro Leu Arg Asp His Glu Asn Leu Lys Asn Leu 
        755                 760                 765             


Trp Val Lys Ile Asp Leu Asp Leu Leu Ser Arg Val Pro Gly His Ser 
    770                 775                 780                 


Ser Leu His Ala Ala Pro Ala Lys Pro Asp His Lys Glu Thr Ala Thr 
785                 790                 795                 800 


Lys Pro Lys Arg Gln Thr Ala Val Thr Ala Val Glu Lys Pro Ala Pro 
                805                 810                 815     


Lys Gly Lys Arg Lys His Lys Pro Ile Glu Val Ala Glu Lys Ile Pro 
            820                 825                 830         


Glu Lys Lys Gln Arg Leu Glu Glu Ala Thr Thr Ile Cys Leu Leu Pro 
        835                 840                 845             


Pro Cys Ile Ser Pro Ala Pro Pro His Lys Pro Pro Asn Thr Arg Glu 
    850                 855                 860                 


Asn Asn Ser Ser Arg Arg Ala Asn Arg Arg Lys Glu Glu Lys Leu Phe 
865                 870                 875                 880 


Pro Pro Pro Leu Ser Pro Leu Pro Glu Asp Pro Pro Arg Arg Arg Asn 
                885                 890                 895     


Val Ser Gly Asn Asn Gly Pro Phe Gly Gln Asp Lys Asn Ile Ala Met 
            900                 905                 910         


Thr Gly Gln Ile Thr Ser Thr Lys Pro Lys Arg Thr Glu Gly Lys Phe 
        915                 920                 925             


Cys Ala Thr Phe Lys Gly Ile Ser Glu Gly Asp Thr Pro Lys Lys Ala 
    930                 935                 940                 


Ser Ser Ala Thr Ile Thr Val Thr Asn Thr Ala Ile Ala Thr Ala Thr 
945                 950                 955                 960 


Val Thr Ala Thr Ala Ile Val Thr Thr Thr Val Thr Ala Thr Ala Thr 
                965                 970                 975     


Ala Thr Ala Thr Thr Thr Thr Thr Thr Thr Thr Ile Ser Thr Ile Thr 
            980                 985                 990         


Ser Thr Ile Thr Thr Gly Leu Met  Asp Ser Ser His Leu  Glu Met Thr 
        995                 1000                 1005             


Ser Trp  Ala Ala Leu Pro Leu  Leu Ser Ser Ser Ser  Thr Asn Val 
    1010                 1015                 1020             


Arg Arg  Pro Lys Leu Thr Phe  Asp Asp Ser Val His  Asn Ala Asp 
    1025                 1030                 1035             


Tyr Tyr  Met Gln Glu Ala Lys  Lys Leu Lys His Lys  Ala Asp Ala 
    1040                 1045                 1050             


Leu Phe  Glu Lys Phe Gly Lys  Ala Val Asn Tyr Ala  Asp Ala Ala 
    1055                 1060                 1065             


Leu Ser  Phe Thr Glu Cys Gly  Asn Ala Met Glu Arg  Asp Pro Leu 
    1070                 1075                 1080             


Glu Ala  Lys Ser Pro Tyr Thr  Met Tyr Ser Glu Thr  Val Glu Leu 
    1085                 1090                 1095             


Leu Arg  Tyr Ala Met Arg Leu  Lys Asn Phe Ala Ser  Pro Leu Ala 
    1100                 1105                 1110             


Ser Asp  Gly Asp Lys Lys Leu  Ala Val Leu Cys Tyr  Arg Cys Leu 
    1115                 1120                 1125             


Ser Leu  Leu Tyr Leu Arg Met  Phe Lys Leu Lys Lys  Asp His Ala 
    1130                 1135                 1140             


Met Lys  Tyr Ser Arg Ser Leu  Met Glu Tyr Phe Lys  Gln Asn Ala 
    1145                 1150                 1155             


Ser Lys  Val Ala Gln Ile Pro  Ser Pro Trp Val Ser  Asn Gly Lys 
    1160                 1165                 1170             


Asn Thr  Pro Ser Pro Val Ser  Leu Asn Asn Val Ser  Pro Ile Asn 
    1175                 1180                 1185             


Ala Met  Gly Asn Cys Asn Asn  Gly Pro Val Thr Ile  Pro Gln Arg 
    1190                 1195                 1200             


Ile His  His Met Ala Ala Ser  His Val Asn Ile Thr  Ser Asn Val 
    1205                 1210                 1215             


Leu Arg  Gly Tyr Glu His Trp  Asp Met Ala Asp Lys  Leu Thr Arg 
    1220                 1225                 1230             


Glu Asn  Lys Glu Phe Phe Gly  Asp Leu Asp Thr Leu  Met Gly Pro 
    1235                 1240                 1245             


Leu Thr  Gln His Ser Ser Met  Thr Asn Leu Val Arg  Tyr Val Arg 
    1250                 1255                 1260             


Gln Gly  Leu Cys Trp Leu Arg  Ile Asp Ala His Leu  Leu 
    1265                 1270                 1275     


<210>  324
<211>  1251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFF3__Homo_sapiens__NP_001020279

<400>  324

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Trp Gly Glu Asp Ile Leu Asn Gln Arg Asn Asp Ser Leu Val Val 
            20                  25                  30          


Glu Phe Gln Ser Ser Ala Ser Arg Cys Arg Ser Val Tyr Glu Pro Asp 
        35                  40                  45              


Arg Asn Ala Leu Arg Arg Lys Glu Arg Glu Arg Arg Asn Gln Glu Thr 
    50                  55                  60                  


Gln Gln Asp Asp Gly Thr Phe Asn Ser Ser Tyr Ser Leu Phe Ser Glu 
65                  70                  75                  80  


Pro Tyr Lys Thr Asn Lys Gly Asp Glu Leu Ser Asn Arg Ile Gln Asn 
                85                  90                  95      


Thr Leu Gly Asn Tyr Asp Glu Met Lys Asp Phe Leu Thr Asp Arg Ser 
            100                 105                 110         


Asn Gln Ser His Leu Val Gly Val Pro Lys Pro Gly Val Pro Gln Thr 
        115                 120                 125             


Pro Val Asn Lys Ile Asp Glu His Phe Val Ala Asp Ser Arg Ala Gln 
    130                 135                 140                 


Asn Gln Pro Ser Ser Ile Cys Ser Thr Thr Thr Ser Thr Pro Ala Ala 
145                 150                 155                 160 


Val Pro Val Gln Gln Ser Lys Arg Gly Thr Met Gly Trp Gln Lys Ala 
                165                 170                 175     


Gly His Pro Pro Ser Asp Gly Gln Gln Arg Ala Thr Gln Gln Gly Ser 
            180                 185                 190         


Leu Arg Thr Leu Leu Gly Asp Gly Val Gly Arg Gln Gln Pro Arg Ala 
        195                 200                 205             


Lys Gln Val Cys Asn Val Glu Val Gly Leu Gln Thr Gln Glu Arg Pro 
    210                 215                 220                 


Pro Ala Met Ala Ala Lys His Ser Ser Ser Gly His Cys Val Gln Asn 
225                 230                 235                 240 


Phe Pro Pro Ser Leu Ala Ser Lys Pro Ser Leu Val Gln Gln Lys Pro 
                245                 250                 255     


Thr Ala Tyr Val Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Asp Glu 
            260                 265                 270         


Ser Pro Lys Leu Lys Ser Ser Ser Glu Thr Ser Val His Cys Thr Ser 
        275                 280                 285             


Tyr Arg Gly Val Pro Ala Ser Lys Pro Glu Pro Ala Arg Ala Lys Ala 
    290                 295                 300                 


Lys Leu Ser Lys Phe Ser Ile Pro Lys Gln Gly Glu Glu Ser Arg Ser 
305                 310                 315                 320 


Gly Glu Thr Asn Ser Cys Val Glu Glu Ile Ile Arg Glu Met Thr Trp 
                325                 330                 335     


Leu Pro Pro Leu Ser Ala Ile Gln Ala Pro Gly Lys Val Glu Pro Thr 
            340                 345                 350         


Lys Phe Pro Phe Pro Asn Lys Asp Ser Gln Leu Val Ser Ser Gly His 
        355                 360                 365             


Asn Asn Pro Lys Lys Gly Asp Ala Glu Pro Glu Ser Pro Asp Asn Gly 
    370                 375                 380                 


Thr Ser Asn Thr Ser Met Leu Glu Asp Asp Leu Lys Leu Ser Ser Asp 
385                 390                 395                 400 


Glu Glu Glu Asn Glu Gln Gln Ala Ala Gln Arg Thr Ala Leu Arg Ala 
                405                 410                 415     


Leu Ser Asp Ser Ala Val Val Gln Gln Pro Asn Cys Arg Thr Ser Val 
            420                 425                 430         


Pro Ser Ser Lys Gly Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
        435                 440                 445             


Ser Ser Ser Asp Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Thr Glu 
    450                 455                 460                 


Ser Ser Ser Ser Glu Ser Glu Gly Ser Lys Pro Pro His Phe Ser Ser 
465                 470                 475                 480 


Pro Glu Ala Glu Pro Ala Ser Ser Asn Lys Trp Gln Leu Asp Lys Trp 
                485                 490                 495     


Leu Asn Lys Val Asn Pro His Lys Pro Pro Ile Leu Ile Gln Asn Glu 
            500                 505                 510         


Ser His Gly Ser Glu Ser Asn Gln Tyr Tyr Asn Pro Val Lys Glu Asp 
        515                 520                 525             


Val Gln Asp Cys Gly Lys Val Pro Asp Val Cys Gln Pro Ser Leu Arg 
    530                 535                 540                 


Glu Lys Glu Ile Lys Ser Thr Cys Lys Glu Glu Gln Arg Pro Arg Thr 
545                 550                 555                 560 


Ala Asn Lys Ala Pro Gly Ser Lys Gly Val Lys Gln Lys Ser Pro Pro 
                565                 570                 575     


Ala Ala Val Ala Val Ala Val Ser Ala Ala Ala Pro Pro Pro Ala Val 
            580                 585                 590         


Pro Cys Ala Pro Ala Glu Asn Ala Pro Ala Pro Ala Arg Arg Ser Ala 
        595                 600                 605             


Gly Lys Lys Pro Thr Arg Arg Thr Glu Arg Thr Ser Ala Gly Asp Gly 
    610                 615                 620                 


Ala Asn Cys His Arg Pro Glu Glu Pro Ala Ala Ala Asp Ala Leu Gly 
625                 630                 635                 640 


Thr Ser Val Val Val Pro Pro Glu Pro Thr Lys Thr Arg Pro Cys Gly 
                645                 650                 655     


Asn Asn Arg Ala Ser His Arg Lys Glu Leu Arg Ser Ser Val Thr Cys 
            660                 665                 670         


Glu Lys Arg Arg Thr Arg Gly Leu Ser Arg Ile Val Pro Lys Ser Lys 
        675                 680                 685             


Glu Phe Ile Glu Thr Glu Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser 
    690                 695                 700                 


Asp Leu Glu Ser Glu Gln Glu Glu Tyr Pro Leu Ser Lys Ala Gln Thr 
705                 710                 715                 720 


Val Ala Ala Ser Ala Ser Ser Gly Asn Asp Gln Arg Leu Lys Glu Ala 
                725                 730                 735     


Ala Ala Asn Gly Gly Ser Gly Pro Arg Ala Pro Val Gly Ser Ile Asn 
            740                 745                 750         


Ala Arg Thr Thr Ser Asp Ile Ala Lys Glu Leu Glu Glu Gln Phe Tyr 
        755                 760                 765             


Thr Leu Val Pro Phe Gly Arg Asn Glu Leu Leu Ser Pro Leu Lys Asp 
    770                 775                 780                 


Ser Asp Glu Ile Arg Ser Leu Trp Val Lys Ile Asp Leu Thr Leu Leu 
785                 790                 795                 800 


Ser Arg Ile Pro Glu His Leu Pro Gln Glu Pro Gly Val Leu Ser Ala 
                805                 810                 815     


Pro Ala Thr Lys Asp Ser Glu Ser Ala Pro Pro Ser His Thr Ser Asp 
            820                 825                 830         


Thr Pro Ala Glu Lys Ala Leu Pro Lys Ser Lys Arg Lys Arg Lys Cys 
        835                 840                 845             


Asp Asn Glu Asp Asp Tyr Arg Glu Ile Lys Lys Ser Gln Gly Glu Lys 
    850                 855                 860                 


Asp Ser Ser Ser Arg Leu Ala Thr Ser Thr Ser Asn Thr Leu Ser Ala 
865                 870                 875                 880 


Asn His Cys Asn Met Asn Ile Asn Ser Val Ala Ile Pro Ile Asn Lys 
                885                 890                 895     


Asn Glu Lys Met Leu Arg Ser Pro Ile Ser Pro Leu Ser Asp Ala Ser 
            900                 905                 910         


Lys His Lys Tyr Thr Ser Glu Asp Leu Thr Ser Ser Ser Arg Pro Asn 
        915                 920                 925             


Gly Asn Ser Leu Phe Thr Ser Ala Ser Ser Ser Lys Lys Pro Lys Ala 
    930                 935                 940                 


Asp Ser Gln Leu Gln Pro His Gly Gly Asp Leu Thr Lys Ala Ala His 
945                 950                 955                 960 


Asn Asn Ser Glu Asn Ile Pro Leu His Lys Ser Arg Pro Gln Thr Lys 
                965                 970                 975     


Pro Trp Ser Pro Gly Ser Asn Gly His Arg Asp Cys Lys Arg Gln Lys 
            980                 985                 990         


Leu Val Phe Asp Asp Met Pro Arg  Ser Ala Asp Tyr Phe  Met Gln Glu 
        995                 1000                 1005             


Ala Lys  Arg Met Lys His Lys  Ala Asp Ala Met Val  Glu Lys Phe 
    1010                 1015                 1020             


Gly Lys  Ala Leu Asn Tyr Ala  Glu Ala Ala Leu Ser  Phe Ile Glu 
    1025                 1030                 1035             


Cys Gly  Asn Ala Met Glu Gln  Gly Pro Met Glu Ser  Lys Ser Pro 
    1040                 1045                 1050             


Tyr Thr  Met Tyr Ser Glu Thr  Val Glu Leu Ile Arg  Tyr Ala Met 
    1055                 1060                 1065             


Arg Leu  Lys Thr His Ser Gly  Pro Asn Ala Thr Pro  Glu Asp Lys 
    1070                 1075                 1080             


Gln Leu  Ala Ala Leu Cys Tyr  Arg Cys Leu Ala Leu  Leu Tyr Trp 
    1085                 1090                 1095             


Arg Met  Phe Arg Leu Lys Arg  Asp His Ala Val Lys  Tyr Ser Lys 
    1100                 1105                 1110             


Ala Leu  Ile Asp Tyr Phe Lys  Asn Ser Ser Lys Ala  Ala Gln Ala 
    1115                 1120                 1125             


Pro Ser  Pro Trp Gly Ala Ser  Gly Lys Ser Thr Gly  Thr Pro Ser 
    1130                 1135                 1140             


Pro Met  Ser Pro Asn Pro Ser  Pro Ala Ser Ser Val  Gly Ser Gln 
    1145                 1150                 1155             


Gly Ser  Leu Ser Asn Ala Ser  Ala Leu Ser Pro Ser  Thr Ile Val 
    1160                 1165                 1170             


Ser Ile  Pro Gln Arg Ile His  Gln Met Ala Ala Asn  His Val Ser 
    1175                 1180                 1185             


Ile Thr  Asn Ser Ile Leu His  Ser Tyr Asp Tyr Trp  Glu Met Ala 
    1190                 1195                 1200             


Asp Asn  Leu Ala Lys Glu Asn  Arg Glu Phe Phe Asn  Asp Leu Asp 
    1205                 1210                 1215             


Leu Leu  Met Gly Pro Val Thr  Leu His Ser Ser Met  Glu His Leu 
    1220                 1225                 1230             


Val Gln  Tyr Ser Gln Gln Gly  Leu His Trp Leu Arg  Asn Ser Ala 
    1235                 1240                 1245             


His Leu  Ser 
    1250     


<210>  325
<211>  1163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFF4__Homo_sapiens__NP_055238

<400>  325

Met Asn Arg Glu Asp Arg Asn Val Leu Arg Met Lys Glu Arg Glu Arg 
1               5                   10                  15      


Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp Ala Phe Pro Pro Ser Ser 
            20                  25                  30          


Pro Leu Phe Ala Glu Pro Tyr Lys Val Thr Ser Lys Glu Asp Lys Leu 
        35                  40                  45              


Ser Ser Arg Ile Gln Ser Met Leu Gly Asn Tyr Asp Glu Met Lys Asp 
    50                  55                  60                  


Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu Val Ala Ile Pro Lys Pro 
65                  70                  75                  80  


Thr Val Pro Pro Ser Ala Asp Glu Lys Ser Asn Pro Asn Phe Phe Glu 
                85                  90                  95      


Gln Arg His Gly Gly Ser His Gln Ser Ser Lys Trp Thr Pro Val Gly 
            100                 105                 110         


Pro Ala Pro Ser Thr Ser Gln Ser Gln Lys Arg Ser Ser Gly Leu Gln 
        115                 120                 125             


Ser Gly His Ser Ser Gln Arg Thr Ser Ala Gly Ser Ser Ser Gly Thr 
    130                 135                 140                 


Asn Ser Ser Gly Gln Arg His Asp Arg Glu Ser Tyr Asn Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Ser Arg Lys Lys Gly Gln His Gly Ser Glu His Ser Lys Ser 
                165                 170                 175     


Arg Ser Ser Ser Pro Gly Lys Pro Gln Ala Val Ser Ser Leu Asn Ser 
            180                 185                 190         


Ser His Ser Arg Ser His Gly Asn Asp His His Ser Lys Glu His Gln 
        195                 200                 205             


Arg Ser Lys Ser Pro Arg Asp Pro Asp Ala Asn Trp Asp Ser Pro Ser 
    210                 215                 220                 


Arg Val Pro Phe Ser Ser Gly Gln His Ser Thr Gln Ser Phe Pro Pro 
225                 230                 235                 240 


Ser Leu Met Ser Lys Ser Asn Ser Met Leu Gln Lys Pro Thr Ala Tyr 
                245                 250                 255     


Val Arg Pro Met Asp Gly Gln Glu Ser Met Glu Pro Lys Leu Ser Ser 
            260                 265                 270         


Glu His Tyr Ser Ser Gln Ser His Gly Asn Ser Met Thr Glu Leu Lys 
        275                 280                 285             


Pro Ser Ser Lys Ala His Leu Thr Lys Leu Lys Ile Pro Ser Gln Pro 
    290                 295                 300                 


Leu Asp Ala Ser Ala Ser Gly Asp Val Ser Cys Val Asp Glu Ile Leu 
305                 310                 315                 320 


Lys Glu Met Thr His Ser Trp Pro Pro Pro Leu Thr Ala Ile His Thr 
                325                 330                 335     


Pro Cys Lys Thr Glu Pro Ser Lys Phe Pro Phe Pro Thr Lys Glu Ser 
            340                 345                 350         


Gln Gln Ser Asn Phe Gly Thr Gly Glu Gln Lys Arg Tyr Asn Pro Ser 
        355                 360                 365             


Lys Thr Ser Asn Gly His Gln Ser Lys Ser Met Leu Lys Asp Asp Leu 
    370                 375                 380                 


Lys Leu Ser Ser Ser Glu Asp Ser Asp Gly Glu Gln Asp Cys Asp Lys 
385                 390                 395                 400 


Thr Met Pro Arg Ser Thr Pro Gly Ser Asn Ser Glu Pro Ser His His 
                405                 410                 415     


Asn Ser Glu Gly Ala Asp Asn Ser Arg Asp Asp Ser Ser Ser His Ser 
            420                 425                 430         


Gly Ser Glu Ser Ser Ser Gly Ser Asp Ser Glu Ser Glu Ser Ser Ser 
        435                 440                 445             


Ser Asp Ser Glu Ala Asn Glu Pro Ser Gln Ser Ala Ser Pro Glu Pro 
    450                 455                 460                 


Glu Pro Pro Pro Thr Asn Lys Trp Gln Leu Asp Asn Trp Leu Asn Lys 
465                 470                 475                 480 


Val Asn Pro His Lys Val Ser Pro Ala Ser Ser Val Asp Ser Asn Ile 
                485                 490                 495     


Pro Ser Ser Gln Gly Tyr Lys Lys Glu Gly Arg Glu Gln Gly Thr Gly 
            500                 505                 510         


Asn Ser Tyr Thr Asp Thr Ser Gly Pro Lys Glu Thr Ser Ser Ala Thr 
        515                 520                 525             


Pro Gly Arg Asp Ser Lys Thr Ile Gln Lys Gly Ser Glu Ser Gly Arg 
    530                 535                 540                 


Gly Arg Gln Lys Ser Pro Ala Gln Ser Asp Ser Thr Thr Gln Arg Arg 
545                 550                 555                 560 


Thr Val Gly Lys Lys Gln Pro Lys Lys Ala Glu Lys Ala Ala Ala Glu 
                565                 570                 575     


Glu Pro Arg Gly Gly Leu Lys Ile Glu Ser Glu Thr Pro Val Asp Leu 
            580                 585                 590         


Ala Ser Ser Met Pro Ser Ser Arg His Lys Ala Ala Thr Lys Gly Ser 
        595                 600                 605             


Arg Lys Pro Asn Ile Lys Lys Glu Ser Lys Ser Ser Pro Arg Pro Thr 
    610                 615                 620                 


Ala Glu Lys Lys Lys Tyr Lys Ser Thr Ser Lys Ser Ser Gln Lys Ser 
625                 630                 635                 640 


Arg Glu Ile Ile Glu Thr Asp Thr Ser Ser Ser Asp Ser Asp Glu Ser 
                645                 650                 655     


Glu Ser Leu Pro Pro Ser Ser Gln Thr Pro Lys Tyr Pro Glu Ser Asn 
            660                 665                 670         


Arg Thr Pro Val Lys Pro Ser Ser Val Glu Glu Glu Asp Ser Phe Phe 
        675                 680                 685             


Arg Gln Arg Met Phe Ser Pro Met Glu Glu Lys Glu Leu Leu Ser Pro 
    690                 695                 700                 


Leu Ser Glu Pro Asp Asp Arg Tyr Pro Leu Ile Val Lys Ile Asp Leu 
705                 710                 715                 720 


Asn Leu Leu Thr Arg Ile Pro Gly Lys Pro Tyr Lys Glu Thr Glu Pro 
                725                 730                 735     


Pro Lys Gly Glu Lys Lys Asn Val Pro Glu Lys His Thr Arg Glu Ala 
            740                 745                 750         


Gln Lys Gln Ala Ser Glu Lys Val Ser Asn Lys Gly Lys Arg Lys His 
        755                 760                 765             


Lys Asn Glu Asp Asp Asn Arg Ala Ser Glu Ser Lys Lys Pro Lys Thr 
    770                 775                 780                 


Glu Asp Lys Asn Ser Ala Gly His Lys Pro Ser Ser Asn Arg Glu Ser 
785                 790                 795                 800 


Ser Lys Gln Ser Ala Ala Lys Glu Lys Asp Leu Leu Pro Ser Pro Ala 
                805                 810                 815     


Gly Pro Val Pro Ser Lys Asp Pro Lys Thr Glu His Gly Ser Arg Lys 
            820                 825                 830         


Arg Thr Ile Ser Gln Ser Ser Ser Leu Lys Ser Ser Ser Asn Ser Asn 
        835                 840                 845             


Lys Glu Thr Ser Gly Ser Ser Lys Asn Ser Ser Ser Thr Ser Lys Gln 
    850                 855                 860                 


Lys Lys Thr Glu Gly Lys Thr Ser Ser Ser Ser Lys Glu Val Lys Glu 
865                 870                 875                 880 


Lys Ala Pro Ser Ser Ser Ser Asn Cys Pro Pro Ser Ala Pro Thr Leu 
                885                 890                 895     


Asp Ser Ser Lys Pro Arg Arg Thr Lys Leu Val Phe Asp Asp Arg Asn 
            900                 905                 910         


Tyr Ser Ala Asp His Tyr Leu Gln Glu Ala Lys Lys Leu Lys His Asn 
        915                 920                 925             


Ala Asp Ala Leu Ser Asp Arg Phe Glu Lys Ala Val Tyr Tyr Leu Asp 
    930                 935                 940                 


Ala Val Val Ser Phe Ile Glu Cys Gly Asn Ala Leu Glu Lys Asn Ala 
945                 950                 955                 960 


Gln Glu Ser Lys Ser Pro Phe Pro Met Tyr Ser Glu Thr Val Asp Leu 
                965                 970                 975     


Ile Lys Tyr Thr Met Lys Leu Lys Asn Tyr Leu Ala Pro Asp Ala Thr 
            980                 985                 990         


Ala Ala Asp Lys Arg Leu Thr Val  Leu Cys Leu Arg Cys  Glu Ser Leu 
        995                 1000                 1005             


Leu Tyr  Leu Arg Leu Phe Lys  Leu Lys Lys Glu Asn  Ala Leu Lys 
    1010                 1015                 1020             


Tyr Ser  Lys Thr Leu Thr Glu  His Leu Lys Asn Ser  Tyr Asn Asn 
    1025                 1030                 1035             


Ser Gln  Ala Pro Ser Pro Gly  Leu Gly Ser Lys Ala  Val Gly Met 
    1040                 1045                 1050             


Pro Ser  Pro Val Ser Pro Lys  Leu Ser Pro Gly Asn  Ser Gly Asn 
    1055                 1060                 1065             


Tyr Ser  Ser Gly Ala Ser Ser  Ala Ser Ala Ser Gly  Ser Ser Val 
    1070                 1075                 1080             


Thr Ile  Pro Gln Lys Ile His  Gln Met Ala Ala Ser  Tyr Val Gln 
    1085                 1090                 1095             


Val Thr  Ser Asn Phe Leu Tyr  Ala Thr Glu Ile Trp  Asp Gln Ala 
    1100                 1105                 1110             


Glu Gln  Leu Ser Lys Glu Gln  Lys Glu Phe Phe Ala  Glu Leu Asp 
    1115                 1120                 1125             


Lys Val  Met Gly Pro Leu Ile  Phe Asn Ala Ser Ile  Met Thr Asp 
    1130                 1135                 1140             


Leu Val  Arg Tyr Thr Arg Gln  Gly Leu His Trp Leu  Arg Gln Asp 
    1145                 1150                 1155             


Ala Lys  Leu Ile Ser 
    1160             


<210>  326
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFG3L2__Homo_sapiens__NP_006787

<400>  326

Met Ala His Arg Cys Leu Arg Leu Trp Gly Arg Gly Gly Cys Trp Pro 
1               5                   10                  15      


Arg Gly Leu Gln Gln Leu Leu Val Pro Gly Gly Val Gly Pro Gly Glu 
            20                  25                  30          


Gln Pro Cys Leu Arg Thr Leu Tyr Arg Phe Val Thr Thr Gln Ala Arg 
        35                  40                  45              


Ala Ser Arg Asn Ser Leu Leu Thr Asp Ile Ile Ala Ala Tyr Gln Arg 
    50                  55                  60                  


Phe Cys Ser Arg Pro Pro Lys Gly Phe Glu Lys Tyr Phe Pro Asn Gly 
65                  70                  75                  80  


Lys Asn Gly Lys Lys Ala Ser Glu Pro Lys Glu Val Met Gly Glu Lys 
                85                  90                  95      


Lys Glu Ser Lys Pro Ala Ala Thr Thr Arg Ser Ser Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Lys Arg Gly Gly Lys Lys Asp Asp Ser His Trp Trp 
        115                 120                 125             


Ser Arg Phe Gln Lys Gly Asp Ile Pro Trp Asp Asp Lys Asp Phe Arg 
    130                 135                 140                 


Met Phe Phe Leu Trp Thr Ala Leu Phe Trp Gly Gly Val Met Phe Tyr 
145                 150                 155                 160 


Leu Leu Leu Lys Arg Ser Gly Arg Glu Ile Thr Trp Lys Asp Phe Val 
                165                 170                 175     


Asn Asn Tyr Leu Ser Lys Gly Val Val Asp Arg Leu Glu Val Val Asn 
            180                 185                 190         


Lys Arg Phe Val Arg Val Thr Phe Thr Pro Gly Lys Thr Pro Val Asp 
        195                 200                 205             


Gly Gln Tyr Val Trp Phe Asn Ile Gly Ser Val Asp Thr Phe Glu Arg 
    210                 215                 220                 


Asn Leu Glu Thr Leu Gln Gln Glu Leu Gly Ile Glu Gly Glu Asn Arg 
225                 230                 235                 240 


Val Pro Val Val Tyr Ile Ala Glu Ser Asp Gly Ser Phe Leu Leu Ser 
                245                 250                 255     


Met Leu Pro Thr Val Leu Ile Ile Ala Phe Leu Leu Tyr Thr Ile Arg 
            260                 265                 270         


Arg Gly Pro Ala Gly Ile Gly Arg Thr Gly Arg Gly Met Gly Gly Leu 
        275                 280                 285             


Phe Ser Val Gly Glu Thr Thr Ala Lys Val Leu Lys Asp Glu Ile Asp 
    290                 295                 300                 


Val Lys Phe Lys Asp Val Ala Gly Cys Glu Glu Ala Lys Leu Glu Ile 
305                 310                 315                 320 


Met Glu Phe Val Asn Phe Leu Lys Asn Pro Lys Gln Tyr Gln Asp Leu 
                325                 330                 335     


Gly Ala Lys Ile Pro Lys Gly Ala Ile Leu Thr Gly Pro Pro Gly Thr 
            340                 345                 350         


Gly Lys Thr Leu Leu Ala Lys Ala Thr Ala Gly Glu Ala Asn Val Pro 
        355                 360                 365             


Phe Ile Thr Val Ser Gly Ser Glu Phe Leu Glu Met Phe Val Gly Val 
    370                 375                 380                 


Gly Pro Ala Arg Val Arg Asp Leu Phe Ala Leu Ala Arg Lys Asn Ala 
385                 390                 395                 400 


Pro Cys Ile Leu Phe Ile Asp Glu Ile Asp Ala Val Gly Arg Lys Arg 
                405                 410                 415     


Gly Arg Gly Asn Phe Gly Gly Gln Ser Glu Gln Glu Asn Thr Leu Asn 
            420                 425                 430         


Gln Leu Leu Val Glu Met Asp Gly Phe Asn Thr Thr Thr Asn Val Val 
        435                 440                 445             


Ile Leu Ala Gly Thr Asn Arg Pro Asp Ile Leu Asp Pro Ala Leu Leu 
    450                 455                 460                 


Arg Pro Gly Arg Phe Asp Arg Gln Ile Phe Ile Gly Pro Pro Asp Ile 
465                 470                 475                 480 


Lys Gly Arg Ala Ser Ile Phe Lys Val His Leu Arg Pro Leu Lys Leu 
                485                 490                 495     


Asp Ser Thr Leu Glu Lys Asp Lys Leu Ala Arg Lys Leu Ala Ser Leu 
            500                 505                 510         


Thr Pro Gly Phe Ser Gly Ala Asp Val Ala Asn Val Cys Asn Glu Ala 
        515                 520                 525             


Ala Leu Ile Ala Ala Arg His Leu Ser Asp Ser Ile Asn Gln Lys His 
    530                 535                 540                 


Phe Glu Gln Ala Ile Glu Arg Val Ile Gly Gly Leu Glu Lys Lys Thr 
545                 550                 555                 560 


Gln Val Leu Gln Pro Glu Glu Lys Lys Thr Val Ala Tyr His Glu Ala 
                565                 570                 575     


Gly His Ala Val Ala Gly Trp Tyr Leu Glu His Ala Asp Pro Leu Leu 
            580                 585                 590         


Lys Val Ser Ile Ile Pro Arg Gly Lys Gly Leu Gly Tyr Ala Gln Tyr 
        595                 600                 605             


Leu Pro Lys Glu Gln Tyr Leu Tyr Thr Lys Glu Gln Leu Leu Asp Arg 
    610                 615                 620                 


Met Cys Met Thr Leu Gly Gly Arg Val Ser Glu Glu Ile Phe Phe Gly 
625                 630                 635                 640 


Arg Ile Thr Thr Gly Ala Gln Asp Asp Leu Arg Lys Val Thr Gln Ser 
                645                 650                 655     


Ala Tyr Ala Gln Ile Val Gln Phe Gly Met Asn Glu Lys Val Gly Gln 
            660                 665                 670         


Ile Ser Phe Asp Leu Pro Arg Gln Gly Asp Met Val Leu Glu Lys Pro 
        675                 680                 685             


Tyr Ser Glu Ala Thr Ala Arg Leu Ile Asp Asp Glu Val Arg Ile Leu 
    690                 695                 700                 


Ile Asn Asp Ala Tyr Lys Arg Thr Val Ala Leu Leu Thr Glu Lys Lys 
705                 710                 715                 720 


Ala Asp Val Glu Lys Val Ala Leu Leu Leu Leu Glu Lys Glu Val Leu 
                725                 730                 735     


Asp Lys Asn Asp Met Val Glu Leu Leu Gly Pro Arg Pro Phe Ala Glu 
            740                 745                 750         


Lys Ser Thr Tyr Glu Glu Phe Val Glu Gly Thr Gly Ser Leu Asp Glu 
        755                 760                 765             


Asp Thr Ser Leu Pro Glu Gly Leu Lys Asp Trp Asn Lys Glu Arg Glu 
    770                 775                 780                 


Lys Glu Lys Glu Glu Pro Pro Gly Glu Lys Val Ala Asn 
785                 790                 795         


<210>  327
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFM__Homo_sapiens__NP_001124

<400>  327

Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu 
1               5                   10                  15      


Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe 
            20                  25                  30          


Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu 
    50                  55                  60                  


Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp 
65                  70                  75                  80  


Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 
                85                  90                  95      


Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 
            100                 105                 110         


Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 
        115                 120                 125             


Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 
    130                 135                 140                 


Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn 
145                 150                 155                 160 


His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro 
                165                 170                 175     


Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys 
            180                 185                 190         


Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro 
        195                 200                 205             


Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys 
    210                 215                 220                 


Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 
225                 230                 235                 240 


Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 
                245                 250                 255     


Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly 
            260                 265                 270         


Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile 
        275                 280                 285             


Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp 
305                 310                 315                 320 


Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser 
                325                 330                 335     


Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 
            340                 345                 350         


Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 
        355                 360                 365             


Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 
    370                 375                 380                 


Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys 
385                 390                 395                 400 


Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys 
                405                 410                 415     


Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu 
            420                 425                 430         


Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val 
        435                 440                 445             


Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu 
    450                 455                 460                 


Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 
465                 470                 475                 480 


Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 
                485                 490                 495     


His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 
            500                 505                 510         


Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu 
        515                 520                 525             


Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln 
    530                 535                 540                 


Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu 
545                 550                 555                 560 


Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val 
                565                 570                 575     


Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 
            580                 585                 590         


Glu Ser Pro Lys Ile Gly Asn 
        595                 


<210>  328
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFP__Homo_sapiens__NP_001125

<400>  328

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  329
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGA__Homo_sapiens__NP_000018

<400>  329

Met Ala Arg Lys Ser Asn Leu Pro Val Leu Leu Val Pro Phe Leu Leu 
1               5                   10                  15      


Cys Gln Ala Leu Val Arg Cys Ser Ser Pro Leu Pro Leu Val Val Asn 
            20                  25                  30          


Thr Trp Pro Phe Lys Asn Ala Thr Glu Ala Ala Trp Arg Ala Leu Ala 
        35                  40                  45              


Ser Gly Gly Ser Ala Leu Asp Ala Val Glu Ser Gly Cys Ala Met Cys 
    50                  55                  60                  


Glu Arg Glu Gln Cys Asp Gly Ser Val Gly Phe Gly Gly Ser Pro Asp 
65                  70                  75                  80  


Glu Leu Gly Glu Thr Thr Leu Asp Ala Met Ile Met Asp Gly Thr Thr 
                85                  90                  95      


Met Asp Val Gly Ala Val Gly Asp Leu Arg Arg Ile Lys Asn Ala Ile 
            100                 105                 110         


Gly Val Ala Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu Val 
        115                 120                 125             


Gly Glu Ser Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala 
145                 150                 155                 160 


Arg Asn Cys Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser 
                165                 170                 175     


Lys Tyr Cys Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile 
            180                 185                 190         


Pro Ile His Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly 
        195                 200                 205             


Met Val Val Ile His Lys Thr Gly His Ile Ala Ala Gly Thr Ser Thr 
    210                 215                 220                 


Asn Gly Ile Lys Phe Lys Ile His Gly Arg Val Gly Asp Ser Pro Ile 
225                 230                 235                 240 


Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala Ala 
                245                 250                 255     


Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln Ala 
            260                 265                 270         


Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln Lys 
        275                 280                 285             


Val Ile Ser Arg Ile Gln Lys His Phe Pro Glu Phe Phe Gly Ala Val 
    290                 295                 300                 


Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala Cys Asn Lys Leu 
305                 310                 315                 320 


Ser Thr Phe Thr Gln Phe Ser Phe Met Val Tyr Asn Ser Glu Lys Asn 
                325                 330                 335     


Gln Pro Thr Glu Glu Lys Val Asp Cys Ile 
            340                 345     


<210>  330
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGAP1__Homo_sapiens__NP_001032208

<400>  330

Met Asn Tyr Gln Gln Gln Leu Ala Asn Ser Ala Ala Ile Arg Ala Glu 
1               5                   10                  15      


Ile Gln Arg Phe Glu Ser Val His Pro Asn Ile Tyr Ser Ile Tyr Glu 
            20                  25                  30          


Leu Leu Glu Arg Val Glu Glu Pro Val Leu Gln Asn Gln Ile Arg Glu 
        35                  40                  45              


His Val Ile Ala Ile Glu Asp Ala Phe Val Asn Ser Gln Glu Trp Thr 
    50                  55                  60                  


Leu Ser Arg Ser Val Pro Glu Leu Lys Val Gly Ile Val Gly Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Lys Ser Ala Leu Val His Arg Tyr Leu Thr Gly Thr Tyr 
                85                  90                  95      


Val Gln Glu Glu Ser Pro Glu Gly Gly Arg Phe Lys Lys Glu Ile Val 
            100                 105                 110         


Val Asp Gly Gln Ser Tyr Leu Leu Leu Ile Arg Asp Glu Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Gln Phe Ala Met Trp Val Asp Ala Val Ile Phe Val Phe 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ile Ser Phe Gln Thr Val Tyr His Tyr Tyr Ser 
145                 150                 155                 160 


Arg Met Ala Asn Tyr Arg Asn Thr Ser Glu Ile Pro Leu Val Leu Val 
                165                 170                 175     


Gly Thr Gln Asp Ala Ile Ser Ser Ala Asn Pro Arg Val Ile Asp Asp 
            180                 185                 190         


Ala Arg Ala Arg Lys Leu Ser Asn Asp Leu Lys Arg Cys Thr Tyr Tyr 
        195                 200                 205             


Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Glu Arg Val Phe Gln Asp 
    210                 215                 220                 


Val Ala Gln Lys Ile Val Ala Thr Arg Lys Lys Gln Gln Leu Ser Ile 
225                 230                 235                 240 


Gly Pro Cys Lys Ser Leu Pro Asn Ser Pro Ser His Ser Ser Val Cys 
                245                 250                 255     


Ser Ala Gln Val Ser Ala Val His Ile Ser Gln Thr Ser Asn Gly Gly 
            260                 265                 270         


Gly Ser Leu Ser Asp Tyr Ser Ser Ser Val Pro Ser Thr Pro Ser Thr 
        275                 280                 285             


Ser Gln Lys Glu Leu Arg Ile Asp Val Pro Pro Thr Ala Asn Thr Pro 
    290                 295                 300                 


Thr Pro Val Arg Lys Gln Ser Lys Arg Arg Ser Asn Leu Phe Thr Ser 
305                 310                 315                 320 


Arg Lys Gly Ser Asp Pro Asp Lys Glu Lys Lys Gly Leu Glu Ser Arg 
                325                 330                 335     


Ala Asp Ser Ile Gly Ser Gly Arg Ala Ile Pro Ile Lys Gln Gly Met 
            340                 345                 350         


Leu Leu Lys Arg Ser Gly Lys Ser Leu Asn Lys Glu Trp Lys Lys Lys 
        355                 360                 365             


Tyr Val Thr Leu Cys Asp Asn Gly Val Leu Thr Tyr His Pro Ser Leu 
    370                 375                 380                 


His Asp Tyr Met Gln Asn Val His Gly Lys Glu Ile Asp Leu Leu Arg 
385                 390                 395                 400 


Thr Thr Val Lys Val Pro Gly Lys Arg Pro Pro Arg Ala Thr Ser Ala 
                405                 410                 415     


Cys Ala Pro Ile Ser Ser Pro Lys Thr Asn Gly Leu Ser Lys Asp Met 
            420                 425                 430         


Ser Ser Leu His Ile Ser Pro Asn Ser Gly Asn Val Thr Ser Ala Ser 
        435                 440                 445             


Gly Ser Gln Met Ala Ser Gly Ile Ser Leu Val Ser Phe Asn Ser Arg 
    450                 455                 460                 


Pro Asp Gly Met His Gln Arg Ser Tyr Ser Val Ser Ser Ala Asp Gln 
465                 470                 475                 480 


Trp Ser Glu Ala Thr Val Ile Ala Asn Ser Ala Ile Ser Ser Asp Thr 
                485                 490                 495     


Gly Leu Gly Asp Ser Val Cys Ser Ser Pro Ser Ile Ser Ser Thr Thr 
            500                 505                 510         


Ser Pro Lys Leu Asp Pro Pro Pro Ser Pro His Ala Asn Arg Lys Lys 
        515                 520                 525             


His Arg Arg Lys Lys Ser Thr Ser Asn Phe Lys Ala Asp Gly Leu Ser 
    530                 535                 540                 


Gly Thr Ala Glu Glu Gln Glu Glu Asn Phe Glu Phe Ile Ile Val Ser 
545                 550                 555                 560 


Leu Thr Gly Gln Thr Trp His Phe Glu Ala Thr Thr Tyr Glu Glu Arg 
                565                 570                 575     


Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser Leu Gln 
            580                 585                 590         


Ser Cys Glu Ser Ser Lys Asn Lys Ser Arg Leu Thr Ser Gln Ser Glu 
        595                 600                 605             


Ala Met Ala Leu Gln Ser Ile Arg Asn Met Arg Gly Asn Ser His Cys 
    610                 615                 620                 


Val Asp Cys Glu Thr Gln Asn Pro Asn Trp Ala Ser Leu Asn Leu Gly 
625                 630                 635                 640 


Ala Leu Met Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu Gly Thr 
                645                 650                 655     


His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro Val Glu 
            660                 665                 670         


Leu Ile Lys Val Met Ser Ser Ile Gly Asn Glu Leu Ala Asn Ser Val 
        675                 680                 685             


Trp Glu Glu Ser Ser Gln Gly Arg Thr Lys Pro Ser Val Asp Ser Thr 
    690                 695                 700                 


Arg Glu Glu Lys Glu Arg Trp Ile Arg Ala Lys Tyr Glu Gln Lys Leu 
705                 710                 715                 720 


Phe Leu Ala Pro Leu Pro Cys Thr Glu Leu Ser Leu Gly Gln His Leu 
                725                 730                 735     


Leu Arg Ala Thr Ala Asp Glu Asp Leu Arg Thr Ala Ile Leu Leu Leu 
            740                 745                 750         


Ala His Gly Ser Arg Asp Glu Val Asn Glu Thr Cys Gly Glu Gly Asp 
        755                 760                 765             


Gly Arg Thr Ala Leu His Leu Ala Cys Arg Lys Gly Asn Val Val Leu 
    770                 775                 780                 


Ala Gln Leu Leu Ile Trp Tyr Gly Val Asp Val Thr Ala Arg Asp Ala 
785                 790                 795                 800 


His Gly Asn Thr Ala Leu Ala Tyr Ala Arg Gln Ala Ser Ser Gln Glu 
                805                 810                 815     


Cys Ile Asp Val Leu Leu Gln Tyr Gly Cys Pro Asp Glu Arg Phe Val 
            820                 825                 830         


Leu Met Ala Thr Pro Asn Leu Ser Arg Arg Asn Asn Asn Arg Asn Asn 
        835                 840                 845             


Ser Ser Gly Arg Val Pro Thr Ile Ile 
    850                 855         


<210>  331
<211>  1192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGAP2__Homo_sapiens__NP_001116244

<400>  331

Met Ser Arg Gly Ala Gly Ala Leu Gln Arg Arg Thr Thr Thr Tyr Leu 
1               5                   10                  15      


Ile Ser Leu Thr Leu Val Lys Leu Glu Ser Val Pro Pro Pro Pro Pro 
            20                  25                  30          


Ser Pro Ser Ala Ala Ala Ala Gly Ala Ala Gly Ala Arg Gly Ser Glu 
        35                  40                  45              


Thr Gly Asp Pro Gly Ser Pro Arg Gly Ala Glu Glu Pro Gly Lys Lys 
    50                  55                  60                  


Arg His Glu Arg Leu Phe His Arg Gln Asp Ala Leu Trp Ile Ser Thr 
65                  70                  75                  80  


Ser Ser Ala Gly Thr Gly Gly Ala Glu Pro Pro Ala Leu Ser Pro Ala 
                85                  90                  95      


Pro Ala Ser Pro Ala Arg Pro Val Ser Pro Ala Pro Gly Arg Arg Leu 
            100                 105                 110         


Ser Leu Trp Ala Val Pro Pro Gly Pro Pro Leu Ser Gly Gly Leu Ser 
        115                 120                 125             


Pro Asp Pro Lys Pro Gly Gly Ala Pro Thr Ser Ser Arg Arg Pro Leu 
    130                 135                 140                 


Leu Ser Ser Pro Ser Trp Gly Gly Pro Glu Pro Glu Gly Arg Ala Gly 
145                 150                 155                 160 


Gly Gly Ile Pro Gly Ser Ser Ser Pro His Pro Gly Thr Gly Ser Arg 
                165                 170                 175     


Arg Leu Lys Val Ala Pro Pro Pro Pro Ala Pro Lys Pro Cys Lys Thr 
            180                 185                 190         


Val Thr Thr Ser Gly Ala Lys Ala Gly Gly Gly Lys Gly Ala Gly Ser 
        195                 200                 205             


Arg Leu Ser Trp Pro Glu Ser Glu Gly Lys Pro Arg Val Lys Gly Ser 
    210                 215                 220                 


Lys Ser Ser Ala Gly Thr Gly Ala Ser Val Ser Ala Ala Ala Thr Ala 
225                 230                 235                 240 


Ala Ala Ala Gly Gly Gly Gly Ser Thr Ala Ser Thr Ser Gly Gly Val 
                245                 250                 255     


Gly Ala Gly Ala Gly Ala Arg Gly Lys Leu Ser Pro Arg Lys Gly Lys 
            260                 265                 270         


Ser Lys Thr Leu Asp Asn Ser Asp Leu His Pro Gly Pro Pro Ala Gly 
        275                 280                 285             


Ser Pro Pro Pro Leu Thr Leu Pro Pro Thr Pro Ser Pro Ala Thr Ala 
    290                 295                 300                 


Val Thr Ala Ala Ser Ala Gln Pro Pro Gly Pro Ala Pro Pro Ile Thr 
305                 310                 315                 320 


Leu Glu Pro Pro Ala Pro Gly Leu Lys Arg Gly Arg Glu Gly Gly Arg 
                325                 330                 335     


Ala Ser Thr Arg Asp Arg Lys Met Leu Lys Phe Ile Ser Gly Ile Phe 
            340                 345                 350         


Thr Lys Ser Thr Gly Gly Pro Pro Gly Ser Gly Pro Leu Pro Gly Pro 
        355                 360                 365             


Pro Ser Leu Ser Ser Gly Ser Gly Ser Arg Glu Leu Leu Gly Ala Glu 
    370                 375                 380                 


Leu Arg Ala Ser Pro Lys Ala Val Ile Asn Ser Gln Glu Trp Thr Leu 
385                 390                 395                 400 


Ser Arg Ser Ile Pro Glu Leu Arg Leu Gly Val Leu Gly Asp Ala Arg 
                405                 410                 415     


Ser Gly Lys Ser Ser Leu Ile His Arg Phe Leu Thr Gly Ser Tyr Gln 
            420                 425                 430         


Val Leu Glu Lys Thr Glu Ser Glu Gln Tyr Lys Lys Glu Met Leu Val 
        435                 440                 445             


Asp Gly Gln Thr His Leu Val Leu Ile Arg Glu Glu Ala Gly Ala Pro 
    450                 455                 460                 


Asp Ala Lys Phe Ser Gly Trp Ala Asp Ala Val Ile Phe Val Phe Ser 
465                 470                 475                 480 


Leu Glu Asp Glu Asn Ser Phe Gln Ala Val Ser Arg Leu His Gly Gln 
                485                 490                 495     


Leu Ser Ser Leu Arg Gly Glu Gly Arg Gly Gly Leu Ala Leu Ala Leu 
            500                 505                 510         


Val Gly Thr Gln Asp Arg Ile Ser Ala Ser Ser Pro Arg Val Val Gly 
        515                 520                 525             


Asp Ala Arg Ala Arg Ala Leu Cys Ala Asp Met Lys Arg Cys Ser Tyr 
    530                 535                 540                 


Tyr Glu Thr Cys Ala Thr Tyr Gly Leu Asn Val Asp Arg Val Phe Gln 
545                 550                 555                 560 


Glu Val Ala Gln Lys Val Val Thr Leu Arg Lys Gln Gln Gln Leu Leu 
                565                 570                 575     


Ala Ala Cys Lys Ser Leu Pro Ser Ser Pro Ser His Ser Ala Ala Ser 
            580                 585                 590         


Thr Pro Val Ala Gly Gln Ala Ser Asn Gly Gly His Thr Ser Asp Tyr 
        595                 600                 605             


Ser Ser Ser Leu Pro Ser Ser Pro Asn Val Gly His Arg Glu Leu Arg 
    610                 615                 620                 


Ala Glu Ala Ala Ala Val Ala Gly Leu Ser Thr Pro Gly Ser Leu His 
625                 630                 635                 640 


Arg Ala Ala Lys Arg Arg Thr Ser Leu Phe Ala Asn Arg Arg Gly Ser 
                645                 650                 655     


Asp Ser Glu Lys Arg Ser Leu Asp Ser Arg Gly Glu Thr Thr Gly Ser 
            660                 665                 670         


Gly Arg Ala Ile Pro Ile Lys Gln Ser Phe Leu Leu Lys Arg Ser Gly 
        675                 680                 685             


Asn Ser Leu Asn Lys Glu Trp Lys Lys Lys Tyr Val Thr Leu Ser Ser 
    690                 695                 700                 


Asn Gly Phe Leu Leu Tyr His Pro Ser Ile Asn Asp Tyr Ile His Ser 
705                 710                 715                 720 


Thr His Gly Lys Glu Met Asp Leu Leu Arg Thr Thr Val Lys Val Pro 
                725                 730                 735     


Gly Lys Arg Pro Pro Arg Ala Ile Ser Ala Phe Gly Pro Ser Ala Ser 
            740                 745                 750         


Ile Asn Gly Leu Val Lys Asp Met Ser Thr Val Gln Met Gly Glu Gly 
        755                 760                 765             


Leu Glu Ala Thr Thr Pro Met Pro Ser Pro Ser Pro Ser Pro Ser Ser 
    770                 775                 780                 


Leu Gln Pro Pro Pro Asp Gln Thr Ser Lys His Leu Leu Lys Pro Asp 
785                 790                 795                 800 


Arg Asn Leu Ala Arg Ala Leu Ser Thr Asp Cys Thr Pro Ser Gly Asp 
                805                 810                 815     


Leu Ser Pro Leu Ser Arg Glu Pro Pro Pro Ser Pro Met Val Lys Lys 
            820                 825                 830         


Gln Arg Arg Lys Lys Leu Thr Thr Pro Ser Lys Thr Glu Gly Ser Ala 
        835                 840                 845             


Gly Gln Ala Glu Ala Lys Arg Lys Met Trp Lys Leu Lys Ser Phe Gly 
    850                 855                 860                 


Ser Leu Arg Asn Ile Tyr Lys Ala Glu Glu Asn Phe Glu Phe Leu Ile 
865                 870                 875                 880 


Val Ser Ser Thr Gly Gln Thr Trp His Phe Glu Ala Ala Ser Phe Glu 
                885                 890                 895     


Glu Arg Asp Ala Trp Val Gln Ala Ile Glu Ser Gln Ile Leu Ala Ser 
            900                 905                 910         


Leu Gln Cys Cys Glu Ser Ser Lys Val Lys Leu Arg Thr Asp Ser Gln 
        915                 920                 925             


Ser Glu Ala Val Ala Ile Gln Ala Ile Arg Asn Ala Lys Gly Asn Ser 
    930                 935                 940                 


Ile Cys Val Asp Cys Gly Ala Pro Asn Pro Thr Trp Ala Ser Leu Asn 
945                 950                 955                 960 


Leu Gly Ala Leu Ile Cys Ile Glu Cys Ser Gly Ile His Arg Asn Leu 
                965                 970                 975     


Gly Thr His Leu Ser Arg Val Arg Ser Leu Asp Leu Asp Asp Trp Pro 
            980                 985                 990         


Arg Glu Leu Thr Leu Val Leu Thr  Ala Ile Gly Asn Asp  Thr Ala Asn 
        995                 1000                 1005             


Arg Val  Trp Glu Ser Asp Thr  Arg Gly Arg Ala Lys  Pro Ser Arg 
    1010                 1015                 1020             


Asp Ser  Ser Arg Glu Glu Arg  Glu Ser Trp Ile Arg  Ala Lys Tyr 
    1025                 1030                 1035             


Glu Gln  Leu Leu Phe Leu Ala  Pro Leu Ser Thr Ser  Glu Glu Pro 
    1040                 1045                 1050             


Leu Gly  Arg Gln Leu Trp Ala  Ala Val Gln Ala Gln  Asp Val Ala 
    1055                 1060                 1065             


Thr Val  Leu Leu Leu Leu Ala  His Ala Arg His Gly  Pro Leu Asp 
    1070                 1075                 1080             


Thr Ser  Val Glu Asp Pro Gln  Leu Arg Ser Pro Leu  His Leu Ala 
    1085                 1090                 1095             


Ala Glu  Leu Ala His Val Val  Ile Thr Gln Leu Leu  Leu Trp Tyr 
    1100                 1105                 1110             


Gly Ala  Asp Val Ala Ala Arg  Asp Ala Gln Gly Arg  Thr Ala Leu 
    1115                 1120                 1125             


Phe Tyr  Ala Arg Gln Ala Gly  Ser Gln Leu Cys Ala  Asp Ile Leu 
    1130                 1135                 1140             


Leu Gln  His Gly Cys Pro Gly  Glu Gly Gly Ser Ala  Ala Thr Thr 
    1145                 1150                 1155             


Pro Ser  Ala Ala Thr Thr Pro  Ser Ile Thr Ala Thr  Pro Ser Pro 
    1160                 1165                 1170             


Arg Arg  Arg Ser Ser Ala Ala  Ser Val Gly Arg Ala  Asp Ala Pro 
    1175                 1180                 1185             


Val Ala  Leu Val 
    1190         


<210>  332
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGAP3__Homo_sapiens__NP_001036000

<400>  332

Met Asn Phe Gln Ala Gly Gly Gly Gln Ser Pro Gln Gln Gln Gln Ser 
1               5                   10                  15      


Leu Ala Ala Pro Gly Gly Gly Gly Ala Ala Ala Gln Gln Leu Val Cys 
            20                  25                  30          


Gly Gly Gln Phe Gly Gly Ala Gly Pro Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Ser Gln Gln Leu Ala Gly Gly Pro Pro Gln Gln Phe Ala Leu Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ile Arg Ala Glu Ile Gln Arg Phe Glu Ser Val His 
65                  70                  75                  80  


Pro Asn Ile Tyr Ala Ile Tyr Asp Leu Ile Glu Arg Ile Glu Asp Leu 
                85                  90                  95      


Ala Leu Gln Asn Gln Ile Arg Glu His Val Ile Ser Ile Glu Asp Ser 
            100                 105                 110         


Phe Val Asn Ser Gln Glu Trp Thr Leu Ser Arg Ser Val Pro Glu Leu 
        115                 120                 125             


Lys Val Gly Ile Val Gly Asn Leu Ser Ser Gly Lys Ser Ala Leu Val 
    130                 135                 140                 


His Arg Tyr Leu Thr Gly Thr Tyr Val Gln Glu Glu Ser Pro Glu Gly 
145                 150                 155                 160 


Gly Arg Phe Lys Lys Glu Ile Val Val Asp Gly Gln Ser Tyr Leu Leu 
                165                 170                 175     


Leu Ile Arg Asp Glu Gly Gly Pro Pro Glu Leu Gln Phe Ala Ala Trp 
            180                 185                 190         


Val Asp Ala Val Val Phe Val Phe Ser Leu Glu Asp Glu Ile Ser Phe 
        195                 200                 205             


Gln Thr Val Tyr Asn Tyr Phe Leu Arg Leu Cys Ser Phe Arg Asn Ala 
    210                 215                 220                 


Ser Glu Val Pro Met Val Leu Val Gly Thr Gln Asp Ala Ile Ser Ala 
225                 230                 235                 240 


Ala Asn Pro Arg Val Ile Asp Asp Ser Arg Ala Arg Lys Leu Ser Thr 
                245                 250                 255     


Asp Leu Lys Arg Cys Thr Tyr Tyr Glu Thr Cys Ala Thr Tyr Gly Leu 
            260                 265                 270         


Asn Val Glu Arg Val Phe Gln Asp Val Ala Gln Lys Val Val Ala Leu 
        275                 280                 285             


Arg Lys Lys Gln Gln Leu Ala Ile Gly Pro Cys Lys Ser Leu Pro Asn 
    290                 295                 300                 


Ser Pro Ser His Ser Ala Val Ser Ala Ala Ser Ile Pro Ala Val His 
305                 310                 315                 320 


Ile Asn Gln Ala Thr Asn Gly Gly Gly Ser Ala Phe Ser Asp Tyr Ser 
                325                 330                 335     


Ser Ser Val Pro Ser Thr Pro Ser Ile Ser Gln Arg Glu Leu Arg Ile 
            340                 345                 350         


Glu Thr Ile Ala Ala Ser Ser Thr Pro Thr Pro Ile Arg Lys Gln Ser 
        355                 360                 365             


Lys Arg Arg Ser Asn Ile Phe Thr Ile Cys Ala Thr Val Ser Asn Phe 
    370                 375                 380                 


Ser Ser Thr Lys Arg Pro Phe Gln Leu Leu Pro Asn 
385                 390                 395     


<210>  333
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGAP4__Homo_sapiens__NP_597703

<400>  333

Met Gly Asn Ile Leu Thr Cys Arg Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15      


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30          


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45              


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60                  


His His Val Arg Asp Arg Glu Met Pro Glu Ala Leu Glu Phe Asn Pro 
65                  70                  75                  80  


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95      


Asp Val Val Glu Ile Arg Arg Ser Asn Cys Thr Asn His Val Ser Thr 
            100                 105                 110         


Val Arg Phe Ser Gln Gln Tyr Ser Leu Cys Ser Thr Ile Phe Leu Asp 
        115                 120                 125             


Asp Ser Thr Ala Ile Gln His Tyr Leu Thr Met Thr Ile Ile Ser Val 
    130                 135                 140                 


Thr Leu Glu Ile Pro His His Ile Thr Gln Arg Asp Ala Asp Arg Ser 
145                 150                 155                 160 


Leu Ser Ile Pro Asp Glu Gln Leu His Ser Phe Ala Val Ser Thr Val 
                165                 170                 175     


His Ile Met Lys Lys Arg Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser 
            180                 185                 190         


Ser Ser Ile Pro Ser Thr Pro Ser Thr Ser Gln Glu Asp Pro Gln Phe 
        195                 200                 205             


Ser Val Pro Pro Thr Ala Asn Thr Pro Thr Pro Val Cys Lys Arg Ser 
    210                 215                 220                 


Met Arg Trp Ser Asn Leu Phe Thr Ser Glu Lys Gly Ser Asp Pro Asp 
225                 230                 235                 240 


Lys Glu Arg Lys Ala Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly 
                245                 250                 255     


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
            260                 265                 270         


Trp Leu Lys Thr Trp Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly 
        275                 280                 285             


Val Leu Thr Tyr Tyr Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His 
    290                 295                 300                 


Lys Lys Glu Ile Asp Leu Gln Thr Ser Thr Ile Lys Val Pro Gly Lys 
305                 310                 315                 320 


Trp Pro Ser Leu Ala Thr Ser Ala Cys Thr Pro Ile Ser Thr Ser Lys 
                325                 330                 335     


Ser Asn Gly Leu Ser Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile 
            340                 345                 350         


Cys Phe Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro 
        355                 360                 365             


Pro Pro Ser Pro His Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser 
    370                 375                 380                 


Thr Asn Asn Phe Met Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe 
385                 390                 395                 400 


Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln 
                405                 410                 415     


Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys 
            420                 425                 430         


Ser Gln Leu Thr Ser Gln Ser Lys Ala Met Ala Leu Gln Ser Ile Gln 
        435                 440                 445             


Asn Met Arg Gly Asn Ala His Cys Val Asp Cys Glu Thr Gln Asn Pro 
    450                 455                 460                 


Lys Trp Ala Ser Leu Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser 
465                 470                 475                 480 


Gly Ile His Arg Ser Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu 
                485                 490                 495     


Glu Leu Asp Asp Trp Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile 
            500                 505                 510         


Gly Asn Asp Leu Ala Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln 
        515                 520                 525             


Thr Lys Pro Ser Glu Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile 
    530                 535                 540                 


Arg Ser Lys Tyr Glu Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr 
545                 550                 555                 560 


Glu Leu Ser Leu Gly Gln Gln Leu Leu Arg Ala Thr Ala Asp Glu Asp 
                565                 570                 575     


Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val 
            580                 585                 590         


Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala 
        595                 600                 605             


Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly 
    610                 615                 620                 


Val Asp Val Met Ala Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr 
625                 630                 635                 640 


Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr 
                645                 650                 655     


Gly Cys Pro Asp Lys Cys Val 
            660             


<210>  334
<211>  1066
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGBL1__Homo_sapiens__NP_689549

<400>  334

Met Ile Ser Lys Gly Gly Ser Glu Ala Leu Leu Gln Thr Leu Val Asp 
1               5                   10                  15      


Thr Ala Arg Thr Ala Pro Pro Asp Tyr Asp Ile Leu Leu Pro Leu Phe 
            20                  25                  30          


Arg Leu Leu Ala Lys Val Gly Leu Arg Asp Lys Lys Ile Gly Arg Lys 
        35                  40                  45              


Ala Leu Glu Leu Glu Ala Leu Asp Val Thr Leu Ile Leu Ala Arg Lys 
    50                  55                  60                  


Asn Leu Ser His Gly Gln Asn Leu Leu His Cys Leu Trp Ala Leu Arg 
65                  70                  75                  80  


Val Phe Ala Ser Ser Val Ser Met Gly Ala Met Leu Gly Ile Asn Gly 
                85                  90                  95      


Ala Met Glu Leu Leu Phe Lys Val Ile Thr Pro Tyr Thr Arg Lys Arg 
            100                 105                 110         


Thr Gln Ala Ile Arg Ala Ala Thr Glu Val Leu Ala Ala Leu Leu Lys 
        115                 120                 125             


Ser Lys Ser Asn Gly Arg Arg Ala Val Asn Arg Gly Tyr Val Thr Ser 
    130                 135                 140                 


Leu Leu Gly Leu His Gln Asp Trp His Ser His Asp Thr Ala Asn Ala 
145                 150                 155                 160 


Tyr Val Gln Ile Arg Arg Gly Leu Leu Leu Cys Leu Arg His Ile Ala 
                165                 170                 175     


Ala Leu Arg Ser Gly Arg Glu Ala Phe Leu Ala Ala Gln Gly Met Glu 
            180                 185                 190         


Ile Leu Phe Ser Thr Thr Gln Asn Cys Leu Asp Asp Lys Ser Met Glu 
        195                 200                 205             


Pro Val Ile Ser Val Val Leu Gln Ile Leu Arg Gln Cys Tyr Pro Thr 
    210                 215                 220                 


Ser Pro Leu Pro Leu Val Thr Ala Ser Ser Ala Tyr Ala Phe Pro Val 
225                 230                 235                 240 


Pro Gly Cys Ile Thr Thr Glu Pro Pro His Asp Leu Pro Glu Glu Asp 
                245                 250                 255     


Phe Glu Asp Asp Gly Asp Asp Glu Val Asp Lys Asp Ser Asp Thr Glu 
            260                 265                 270         


Asp Gly Lys Val Glu Asp Asp Asp Leu Glu Thr Asp Val Asn Lys Leu 
        275                 280                 285             


Ser Ser Lys Pro Gly Leu Asp Arg Pro Glu Glu Glu Leu Met Gln Tyr 
    290                 295                 300                 


Glu Val Met Cys Leu Glu Leu Ser Tyr Ser Phe Glu Glu Leu Gln Ser 
305                 310                 315                 320 


Lys Leu Gly Asp Asp Leu Asn Ser Glu Lys Thr Gln Tyr Ala Asn His 
                325                 330                 335     


His His Ile Pro Ala Ala Ala Ser Ser Lys Gln His Cys Tyr Ser Lys 
            340                 345                 350         


Asp Gln Ser Ser Cys Gly Gln Glu Arg Glu Tyr Ala Val Gln Thr Ser 
        355                 360                 365             


Leu Leu Cys Arg Val Lys Thr Gly Arg Ser Thr Val His Leu Gly Ser 
    370                 375                 380                 


Lys Lys Asn Pro Gly Val Asn Leu Tyr Gln Asn Val Gln Ser Asn Ser 
385                 390                 395                 400 


Leu Arg Arg Asp Ser Ser Glu Ser Glu Ile Pro Asp Ile Gln Ala Ser 
                405                 410                 415     


Pro Lys Ala Asp Ala Trp Asp Val Asp Ala Ile Phe Cys Pro Arg Met 
            420                 425                 430         


Ser Ala Ser Phe Ser Asn Ser Thr Arg Thr Arg Glu Val Val Lys Val 
        435                 440                 445             


Ile Asp Lys Leu Leu Gln Thr His Leu Lys Arg Val Pro Phe His Asp 
    450                 455                 460                 


Pro Tyr Leu Tyr Met Ala Lys Ala Arg Arg Thr Ser Ser Val Val Asp 
465                 470                 475                 480 


Phe Lys Met Met Ala Phe Pro Asp Val Trp Gly His Cys Pro Pro Pro 
                485                 490                 495     


Thr Thr Gln Pro Met Leu Glu Arg Lys Cys Gly Val Gln Arg Ile Arg 
            500                 505                 510         


Ile Phe Glu Asp Ile Arg Arg Leu Ile Gln Pro Ser Asp Val Ile Asn 
        515                 520                 525             


Lys Val Val Phe Ser Leu Asp Glu Pro Trp Pro Leu Gln Asp Asn Ala 
    530                 535                 540                 


Ser Asn Cys Leu Arg Phe Phe Ser Lys Phe Glu Ser Gly Asn Leu Arg 
545                 550                 555                 560 


Lys Ala Ile Gln Val Arg Glu Phe Glu Tyr Asp Leu Leu Val Asn Ala 
                565                 570                 575     


Asp Val Asn Ser Thr Gln His Gln Gln Trp Phe Tyr Phe Lys Val Ser 
            580                 585                 590         


Gly Met Gln Ala Ala Ile Pro Tyr His Phe Asn Ile Ile Asn Cys Glu 
        595                 600                 605             


Lys Pro Asn Ser Gln Phe Asn Tyr Gly Met Gln Pro Thr Leu Tyr Ser 
    610                 615                 620                 


Val Lys Glu Ala Leu Leu Gly Lys Pro Thr Trp Ile Arg Thr Gly His 
625                 630                 635                 640 


Glu Ile Cys Tyr Tyr Lys Asn His Tyr Arg Gln Ser Thr Ala Val Ala 
                645                 650                 655     


Gly Gly Ala Ser Gly Lys Cys Tyr Tyr Thr Leu Thr Phe Ala Val Thr 
            660                 665                 670         


Phe Pro His Ser Glu Asp Val Cys Tyr Leu Ala Tyr His Tyr Pro Tyr 
        675                 680                 685             


Thr Tyr Thr Ala Leu Met Thr His Leu Asp Ile Leu Glu Lys Ser Val 
    690                 695                 700                 


Asn Leu Lys Glu Val Tyr Phe Arg Gln Asp Val Leu Cys Gln Thr Leu 
705                 710                 715                 720 


Gly Gly Asn Pro Cys Pro Leu Val Thr Ile Thr Ala Met Pro Glu Ser 
                725                 730                 735     


Asn Ser Asp Glu His Leu Glu Gln Phe Arg His Arg Pro Tyr Gln Val 
            740                 745                 750         


Ile Thr Ala Arg Val His Pro Gly Glu Ser Asn Ala Ser Trp Val Met 
        755                 760                 765             


Lys Gly Thr Leu Glu Phe Leu Val Ser Ser Asp Pro Val Ala Arg Leu 
    770                 775                 780                 


Leu Arg Glu Asn Phe Ile Phe Lys Ile Ile Pro Met Leu Asn Pro Asp 
785                 790                 795                 800 


Gly Val Ile Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu Asp Leu 
                805                 810                 815     


Asn Arg Gln Trp Leu Ser Pro Ser Ala His Leu Gln Pro Thr Ile Tyr 
            820                 825                 830         


His Ala Lys Gly Leu Leu Tyr His Leu Ser Ser Ile Gly Arg Ser Pro 
        835                 840                 845             


Val Val Phe Cys Asp Phe His Gly His Ser Gln Lys Lys Asn Val Phe 
    850                 855                 860                 


Leu Tyr Gly Cys Ser Ile Lys Glu Thr Leu Trp Gln Ala Ala Cys Thr 
865                 870                 875                 880 


Val Gly Thr Ser Thr Ile Leu Glu Glu Val Asn Tyr Arg Thr Leu Pro 
                885                 890                 895     


Lys Ile Leu Asp Lys Leu Ala Pro Ala Phe Thr Met Ser Ser Cys Ser 
            900                 905                 910         


Phe Leu Val Glu Lys Ser Arg Ala Ser Thr Ala Arg Val Val Val Trp 
        915                 920                 925             


Arg Glu Met Gly Val Ser Arg Ser Tyr Thr Met Glu Ser Ser Tyr Cys 
    930                 935                 940                 


Gly Cys Asn Gln Gly Pro Tyr Gln Cys Thr Gln Arg Leu Leu Glu Arg 
945                 950                 955                 960 


Thr Lys Asn Glu Arg Ala His Pro Val Asp Gly Leu Gln Gly Leu Gln 
                965                 970                 975     


Phe Gly Thr Arg Glu Leu Glu Glu Met Gly Ala Met Phe Cys Leu Gly 
            980                 985                 990         


Leu Leu Ile Leu Glu Leu Lys Ser  Ala Ser Cys Ser His  Gln Leu Leu 
        995                 1000                 1005             


Ala Gln  Ala Ala Thr Leu Leu  Ser Ala Glu Glu Asp  Ala Leu Asp 
    1010                 1015                 1020             


Gln His  Leu Gln Arg Leu Lys  Ser Ser Asn Phe Leu  Pro Lys His 
    1025                 1030                 1035             


Ile Trp  Phe Ala Tyr His Phe  Phe Ala Ile Thr Asn  Phe Phe Lys 
    1040                 1045                 1050             


Met Asn  Leu Leu Leu His Val  Ser Pro Val Cys Asp  Thr 
    1055                 1060                 1065     


<210>  335
<211>  902
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGBL2__Homo_sapiens__NP_079059

<400>  335

Met Phe Pro Ala Leu Glu Thr His Leu Lys Gln Thr Ile Pro Asp Pro 
1               5                   10                  15      


Tyr Glu Asp Phe Met Tyr Arg His Leu Gln Tyr Tyr Gly Tyr Phe Lys 
            20                  25                  30          


Ala Gln Arg Gly Ser Leu Pro Asn Ser Ala Thr His Gln His Val Arg 
        35                  40                  45              


Lys Asn Asn Pro Gln Cys Leu Leu Asn Gly Ser Leu Gly Glu Lys Asp 
    50                  55                  60                  


Asp Leu Ile Pro Asp Thr Leu Gln Lys Glu Lys Leu Leu Trp Pro Ile 
65                  70                  75                  80  


Ser Leu Ser Ser Ala Val His Arg Gln Ile Glu Ala Ile Asn Arg Asp 
                85                  90                  95      


Phe His Ser Cys Leu Gly Trp Met Gln Trp Arg Gly Leu Ser Ser Leu 
            100                 105                 110         


Gln Pro Pro Pro Pro Arg Phe Lys Asp Ser Pro Ala Ser Ala Phe Arg 
        115                 120                 125             


Val Ala Gly Ile Thr Asp Ser His Met Leu Ser Leu Pro His Leu Arg 
    130                 135                 140                 


Ser Arg Gln Leu Leu Tyr Asp Glu Leu Asp Glu Val Asn Pro Arg Leu 
145                 150                 155                 160 


Arg Glu Pro Gln Glu Leu Phe Ser Ile Leu Ser Thr Lys Arg Pro Leu 
                165                 170                 175     


Gln Ala Pro Arg Trp Pro Ile Glu Cys Glu Val Ile Lys Glu Asn Ile 
            180                 185                 190         


His His Ile Glu Trp Ala Pro Pro Gln Pro Glu Tyr Phe Tyr Gln Pro 
        195                 200                 205             


Lys Gly Asn Glu Lys Val Pro Glu Ile Val Gly Glu Lys Lys Gly Thr 
    210                 215                 220                 


Val Val Tyr Gln Leu Asp Ser Val Pro Ile Glu Gly Ser Tyr Phe Thr 
225                 230                 235                 240 


Ser Ser Arg Val Gly Gly Lys Arg Gly Ile Val Lys Glu Leu Ala Val 
                245                 250                 255     


Thr Leu Gln Gly Pro Glu Asp Asn Thr Leu Leu Phe Glu Ser Arg Phe 
            260                 265                 270         


Glu Ser Gly Asn Leu Gln Lys Ala Val Arg Val Asp Thr Tyr Glu Tyr 
        275                 280                 285             


Glu Leu Thr Leu Arg Thr Asp Leu Tyr Thr Asn Lys His Thr Gln Trp 
    290                 295                 300                 


Phe Tyr Phe Arg Val Gln Asn Thr Arg Lys Asp Ala Thr Tyr Arg Phe 
305                 310                 315                 320 


Thr Ile Val Asn Leu Leu Lys Pro Lys Ser Leu Tyr Thr Val Gly Met 
                325                 330                 335     


Lys Pro Leu Leu Tyr Ser Gln Leu Asp Ala Asn Thr Arg Asn Ile Gly 
            340                 345                 350         


Trp Arg Arg Glu Gly Asn Glu Ile Lys Tyr Tyr Lys Asn Asn Thr Asp 
        355                 360                 365             


Asp Gly Gln Gln Pro Phe Tyr Cys Leu Thr Trp Thr Ile Gln Phe Pro 
    370                 375                 380                 


Tyr Asp Gln Asp Thr Cys Phe Phe Ala His Phe Tyr Pro Tyr Thr Tyr 
385                 390                 395                 400 


Thr Asp Leu Gln Cys Tyr Leu Leu Ser Val Ala Asn Asn Pro Ile Gln 
                405                 410                 415     


Ser Gln Phe Cys Lys Leu Gln Thr Leu Cys Arg Ser Leu Ala Gly Asn 
            420                 425                 430         


Thr Val Tyr Leu Leu Thr Ile Thr Asn Pro Ser Gln Thr Pro Gln Glu 
        435                 440                 445             


Ala Ala Ala Lys Lys Ala Val Val Leu Ser Ala Arg Val His Pro Gly 
    450                 455                 460                 


Glu Ser Asn Gly Ser Trp Val Met Lys Gly Phe Leu Asp Phe Ile Leu 
465                 470                 475                 480 


Ser Asn Ser Pro Asp Ala Gln Leu Leu Arg Asp Ile Phe Val Phe Lys 
                485                 490                 495     


Val Leu Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg 
            500                 505                 510         


Cys Ser Leu Ala Gly Arg Asp Leu Asn Arg His Tyr Lys Thr Ile Leu 
        515                 520                 525             


Lys Glu Ser Phe Pro Cys Ile Trp Tyr Thr Arg Asn Met Ile Lys Arg 
    530                 535                 540                 


Leu Leu Glu Glu Arg Glu Val Leu Leu Tyr Cys Asp Phe His Gly His 
545                 550                 555                 560 


Ser Arg Lys Asn Asn Ile Phe Leu Tyr Gly Cys Asn Asn Asn Asn Arg 
                565                 570                 575     


Lys Tyr Trp Leu His Glu Arg Val Phe Pro Leu Met Leu Cys Lys Asn 
            580                 585                 590         


Ala Pro Asp Lys Phe Ser Phe His Ser Cys Asn Phe Lys Val Gln Lys 
        595                 600                 605             


Cys Lys Glu Gly Thr Gly Arg Val Val Met Trp Arg Met Gly Ile Leu 
    610                 615                 620                 


Asn Ser Tyr Thr Met Glu Ser Thr Phe Gly Gly Ser Thr Leu Gly Asn 
625                 630                 635                 640 


Lys Arg Asp Thr His Phe Thr Ile Glu Asp Leu Lys Ser Leu Gly Tyr 
                645                 650                 655     


His Val Cys Asp Thr Leu Leu Asp Phe Cys Asp Pro Asp Gln Met Lys 
            660                 665                 670         


Phe Thr Gln Cys Leu Ala Glu Leu Lys Glu Leu Leu Arg Gln Glu Ile 
        675                 680                 685             


His Lys Lys Phe His Glu Leu Gly Gln Asp Val Asp Leu Glu Gly Ser 
    690                 695                 700                 


Trp Ser Asp Ile Ser Leu Ser Asp Ile Glu Ser Ser Thr Ser Gly Ser 
705                 710                 715                 720 


Asp Ser Ser Leu Ser Asp Gly Leu Pro Val His Leu Ala Asn Ile Ala 
                725                 730                 735     


Asp Glu Leu Thr Gln Lys Lys Lys Met Phe Lys Lys Lys Lys Lys Lys 
            740                 745                 750         


Ser Leu Gln Thr Arg Lys Gln Arg Asn Glu Gln Tyr Gln Lys Lys Asn 
        755                 760                 765             


Leu Met Gln Lys Leu Lys Leu Thr Glu Asp Thr Ser Glu Lys Ala Gly 
    770                 775                 780                 


Phe Ala Ser Thr Leu Gln Lys Gln Pro Thr Phe Phe Lys Asn Ser Glu 
785                 790                 795                 800 


Asn Ser Ser Phe Leu Pro Met Lys Asn Glu Asn Pro Arg Leu Asn Glu 
                805                 810                 815     


Thr Asn Leu Asn Arg Arg Asp Lys Asp Thr Pro Leu Asp Pro Ser Met 
            820                 825                 830         


Ala Thr Leu Ile Leu Pro Lys Asn Lys Gly Arg Met Gln Asn Lys Lys 
        835                 840                 845             


Pro Gly Phe Thr Val Ser Cys Ser Pro Lys Arg Thr Ile Asn Ser Ser 
    850                 855                 860                 


Gln Glu Pro Ala Pro Gly Met Lys Pro Asn Trp Pro Arg Ser Arg Tyr 
865                 870                 875                 880 


Pro Ala Thr Lys Arg Gly Cys Ala Ala Met Ala Ala Tyr Pro Ser Leu 
                885                 890                 895     


His Ile Tyr Thr Tyr Pro 
            900         


<210>  336
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGBL3__Homo_sapiens__NP_848658

<400>  336

Met Ser Glu Asp Ser Glu Lys Glu Asp Tyr Ser Asp Arg Thr Ile Ser 
1               5                   10                  15      


Asp Glu Asp Glu Ser Asp Glu Asp Met Phe Met Lys Phe Val Ser Glu 
            20                  25                  30          


Asp Leu His Arg Cys Ala Leu Leu Thr Ala Asp Ser Phe Gly Asp Pro 
        35                  40                  45              


Phe Phe Pro Arg Thr Thr Gln Ile Leu Leu Glu Tyr Gln Leu Gly Arg 
    50                  55                  60                  


Trp Val Pro Arg Leu Arg Glu Pro Arg Asp Leu Tyr Gly Val Ser Ser 
65                  70                  75                  80  


Ser Gly Pro Leu Ser Pro Thr Arg Trp Pro Tyr His Cys Glu Val Ile 
                85                  90                  95      


Asp Glu Lys Val Gln His Ile Asp Trp Thr Pro Ser Cys Pro Glu Pro 
            100                 105                 110         


Val Tyr Ile Pro Thr Gly Leu Glu Thr Glu Pro Leu Tyr Pro Asp Ser 
        115                 120                 125             


Lys Glu Ala Thr Val Val Tyr Leu Ala Glu Asp Ala Tyr Lys Glu Pro 
    130                 135                 140                 


Cys Phe Val Tyr Ser Arg Val Gly Gly Asn Arg Thr Pro Leu Lys Gln 
145                 150                 155                 160 


Pro Val Asp Tyr Arg Asp Asn Thr Leu Met Phe Glu Ala Arg Phe Glu 
                165                 170                 175     


Ser Gly Asn Leu Gln Lys Val Val Lys Val Ala Glu Tyr Glu Tyr Gln 
            180                 185                 190         


Leu Thr Val Arg Pro Asp Leu Phe Thr Asn Lys His Thr Gln Trp Tyr 
        195                 200                 205             


Tyr Phe Gln Val Thr Asn Met Arg Ala Gly Ile Val Tyr Arg Phe Thr 
    210                 215                 220                 


Ile Val Asn Phe Thr Lys Pro Ala Ser Leu Tyr Ser Arg Gly Met Arg 
225                 230                 235                 240 


Pro Leu Phe Tyr Ser Glu Lys Glu Ala Lys Ala His His Ile Gly Trp 
                245                 250                 255     


Gln Arg Ile Gly Asp Gln Ile Lys Tyr Tyr Arg Asn Asn Pro Gly Gln 
            260                 265                 270         


Asp Gly Arg His Tyr Phe Ser Leu Thr Trp Thr Phe Gln Phe Pro His 
        275                 280                 285             


Asn Lys Asp Thr Cys Tyr Phe Ala His Cys Tyr Pro Tyr Thr Tyr Thr 
    290                 295                 300                 


Asn Leu Gln Glu Tyr Leu Ser Gly Ile Asn Asn Asp Pro Val Arg Ser 
305                 310                 315                 320 


Lys Phe Cys Lys Ile Arg Val Leu Cys His Thr Leu Ala Arg Asn Met 
                325                 330                 335     


Val Tyr Ile Leu Thr Ile Thr Thr Pro Leu Lys Asn Ser Asp Ser Arg 
            340                 345                 350         


Lys Arg Lys Ala Val Ile Leu Thr Ala Arg Val His Pro Gly Glu Thr 
        355                 360                 365             


Asn Ser Ser Trp Ile Met Lys Gly Phe Leu Asp Tyr Ile Leu Gly Asn 
    370                 375                 380                 


Ser Ser Asp Ala Gln Leu Leu Arg Asp Thr Phe Val Phe Lys Val Val 
385                 390                 395                 400 


Pro Met Leu Asn Pro Asp Gly Val Ile Val Gly Asn Tyr Arg Cys Ser 
                405                 410                 415     


Leu Ala Gly Arg Asp Leu Asn Arg Asn Tyr Thr Ser Leu Leu Lys Glu 
            420                 425                 430         


Ser Phe Pro Ser Val Trp Tyr Thr Arg Asn Met Val His Arg Leu Met 
        435                 440                 445             


Glu Lys Arg Glu Val Ile Leu Tyr Cys Asp Leu His Gly His Ser Arg 
    450                 455                 460                 


Lys Glu Asn Ile Phe Met Tyr Gly Cys Asp Gly Ser Asp Arg Ser Lys 
465                 470                 475                 480 


Thr Leu Tyr Leu Gln Gln Arg Ile Phe Pro Leu Met Leu Ser Lys Asn 
                485                 490                 495     


Cys Pro Asp Lys Phe Ser Phe Ser Ala Cys Lys Phe Asn Val Gln Lys 
            500                 505                 510         


Ser Lys Glu Gly Thr Gly Arg Val Val Met Trp Lys Met Gly Ile Arg 
        515                 520                 525             


Asn Ser Phe Thr Met Glu Ala Thr Phe Cys Gly Ser Thr Leu Gly Asn 
    530                 535                 540                 


Lys Arg Gly Thr His Phe Ser Thr Lys Asp Leu Glu Ser Met Gly Tyr 
545                 550                 555                 560 


His Phe Cys Asp Ser Leu Leu Asp Tyr Cys Asp Pro Asp Arg Thr Lys 
                565                 570                 575     


Tyr Tyr Arg Cys Leu Lys Glu Leu Glu Glu Met Glu Arg His Ile Thr 
            580                 585                 590         


Leu Glu Lys Val Phe Glu Asp Ser Asp Thr Pro Val Ile Asp Ile Thr 
        595                 600                 605             


Leu Asp Val Glu Ser Ser Ser Arg Gly Ser Asp Ser Ser Glu Ser Ile 
    610                 615                 620                 


Asp Ser Leu Thr Tyr Leu Leu Lys Leu Thr Ser Gln Lys Lys His Leu 
625                 630                 635                 640 


Lys Thr Lys Lys Glu Arg Asn Ser Thr Ile Ala Ser His Gln Asn Ala 
                645                 650                 655     


Arg Gly Gln Glu Val Tyr Asp Arg Gly His Leu Leu Gln Arg His Thr 
            660                 665                 670         


Gln Ser Asn Ser Asp Val Lys Asp Thr Arg Pro Asn Glu Pro Asp Asp 
        675                 680                 685             


Tyr Met Val Asp Tyr Phe Arg Arg Gln Leu Pro Asn Gln Gly Leu Asp 
    690                 695                 700                 


Leu His His Asn Leu Lys Ser Lys Ile Lys Glu Cys Ile Ser Phe Gln 
705                 710                 715                 720 


Ser Lys Lys Thr Gly Ile Asn Trp Thr Asp Asp Glu Lys Arg Ser Tyr 
                725                 730                 735     


Lys Asp Lys Gly Ile Val Gln Thr Gln Glu Ile Leu Gln Tyr Leu Leu 
            740                 745                 750         


Pro Ile Val His Ser Thr Lys Asn Met Gln Thr Thr Gln Ile Lys Gln 
        755                 760                 765             


Leu Phe Asn Pro Arg Thr Asn Phe Gln Ile Gln His Gln Leu Asn Pro 
    770                 775                 780                 


Ala Thr Cys Arg Asn Ile Lys Lys Tyr Ser Thr Ser Trp Thr Ala Pro 
785                 790                 795                 800 


Arg Asn His Pro Phe Val Ile Gln Gly Asp Val Met Ala Asn Ser Ser 
                805                 810                 815     


Glu Trp Val Gln Ser Lys Pro His Arg Ser Leu Glu Ser Leu Ser Pro 
            820                 825                 830         


Leu Lys Gly Pro Lys Lys Asn Lys His Ser Gln Ile Trp Ala Ile Lys 
        835                 840                 845             


Asn Glu Asp Ile Lys Pro Leu Ser Ser Lys Trp Glu Thr Ala Ser Ser 
    850                 855                 860                 


Ser Phe Gly Met Asp Ala Asn Val Leu Lys Tyr Lys Ser Leu Gln Ala 
865                 870                 875                 880 


Glu Glu Thr Asn Gln Gln Ser Ser Lys His Thr Ala Leu His Leu Thr 
                885                 890                 895     


Lys Asn Lys Asp Glu Gln Ala Asn Lys Asn Asp Gly Gln Pro Thr Leu 
            900                 905                 910         


Tyr Leu Lys Phe Gln Arg Glu Ser 
        915                 920 


<210>  337
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGBL4__Homo_sapiens__XP_011540611

<400>  337

Met Ala Glu Gly Ser Gln Ser Ala Pro Glu Ala Gly Asn Asp Met Gly 
1               5                   10                  15      


Asn Asp Asp Ala Ile Gly Gly Asn Val Ser Lys Tyr Ile Val Leu Pro 
            20                  25                  30          


Thr Gly Tyr Cys Gly Gln Pro Lys Lys Gly His Leu Ile Phe Asp Ala 
        35                  40                  45              


Cys Phe Glu Ser Gly Asn Leu Gly Arg Val Asp Gln Val Ser Glu Phe 
    50                  55                  60                  


Glu Tyr Asp Leu Phe Ile Arg Pro Asp Thr Cys Asn Pro Arg Phe Arg 
65                  70                  75                  80  


Val Trp Phe Asn Phe Thr Val Glu Asn Val Lys Glu Ser Gln Val Arg 
                85                  90                  95      


Glu Ile Val Asp Thr Phe Arg Val Val Leu Arg Val Ile Phe Asn Ile 
            100                 105                 110         


Val Asn Phe Ser Lys Thr Lys Ser Leu Tyr Arg Asp Gly Met Ala Pro 
        115                 120                 125             


Met Val Lys Ser Thr Ser Arg Pro Lys Trp Gln Arg Leu Pro Pro Lys 
    130                 135                 140                 


Asn Val Tyr Tyr Tyr Arg Cys Pro Asp His Arg Lys Asn Tyr Val Met 
145                 150                 155                 160 


Ser Phe Ala Phe Cys Phe Asp Arg Glu Glu Asp Ile Tyr Gln Phe Ala 
                165                 170                 175     


Tyr Cys Tyr Pro Tyr Thr Tyr Thr Arg Phe Gln His Tyr Leu Asp Ser 
            180                 185                 190         


Leu Gln Lys Arg Asn Met Asp Tyr Phe Phe Arg Glu Gln Leu Gly Gln 
        195                 200                 205             


Ser Val Gln Gln Arg Lys Leu Asp Leu Leu Thr Ile Thr Ser Pro Asp 
    210                 215                 220                 


Asn Leu Arg Glu Gly Ala Glu Gln Lys Val Val Phe Ile Thr Gly Arg 
225                 230                 235                 240 


Val His Pro Gly Glu Thr Pro Ser Ser Phe Val Cys Gln Gly Ile Ile 
                245                 250                 255     


Asp Phe Leu Val Ser Gln His Pro Ile Ala Cys Val Leu Arg Glu Tyr 
            260                 265                 270         


Leu Val Phe Lys Ile Ala Pro Met Leu Asn Pro Asp Gly Val Tyr Leu 
        275                 280                 285             


Gly Asn Tyr Arg Cys Ser Leu Met Gly Phe Asp Leu Asn Arg His Trp 
    290                 295                 300                 


Leu Asp Pro Ser Pro Trp Val His Pro Thr Leu His Gly Val Lys Gln 
305                 310                 315                 320 


Leu Ile Val Gln Met Tyr Asn Asp Pro Lys Thr Ser Leu Glu Phe Tyr 
                325                 330                 335     


Ile Asp Ile His Ala His Ser Thr Met Met Asn Gly Phe Met Tyr Gly 
            340                 345                 350         


Asn Ile Phe Glu Asp Glu Glu Arg Phe Gln Arg Gln Ala Ile Phe Pro 
        355                 360                 365             


Lys Leu Leu Cys Gln Asn Ala Glu Asp Phe Ser Tyr Ser Ser Thr Ser 
    370                 375                 380                 


Phe Asn Arg Asp Ala Val Lys Ala Gly Thr Gly Arg Arg Phe Leu Gly 
385                 390                 395                 400 


Gly Leu Leu Asp His Thr Ser Tyr Cys Tyr Thr Leu Glu Val Ser Phe 
                405                 410                 415     


Tyr Ser Tyr Ile Ile Ser Gly Thr Thr Ala Ala Val Pro Tyr Thr Glu 
            420                 425                 430         


Glu Ala Tyr Met Lys Leu Gly Arg Asn Val Ala Arg Thr Phe Leu Asp 
        435                 440                 445             


Tyr Tyr Arg Leu Asn Pro Val Val Glu Lys Val Ala Ile Pro Met Pro 
    450                 455                 460                 


Arg Leu Arg Lys Glu Lys Ser Pro Pro Tyr Lys His Pro Leu Leu Arg 
465                 470                 475                 480 


Gly Pro Ala Ser Asn Tyr Pro Asn Ser Lys Gly Asp Lys Lys Ser Ser 
                485                 490                 495     


Val Asn His Lys Asp Pro Ser Thr Pro Phe 
            500                 505     


<210>  338
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGER__Homo_sapiens__NP_001127

<400>  338

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  339
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGFG1__Homo_sapiens__NP_001128659

<400>  339

Met Ala Ala Ser Ala Lys Arg Lys Gln Glu Glu Lys His Leu Lys Met 
1               5                   10                  15      


Leu Arg Asp Met Thr Gly Leu Pro His Asn Arg Lys Cys Phe Asp Cys 
            20                  25                  30          


Asp Gln Arg Gly Pro Thr Tyr Val Asn Met Thr Val Gly Ser Phe Val 
        35                  40                  45              


Cys Thr Ser Cys Ser Gly Ser Leu Arg Gly Leu Asn Pro Pro His Arg 
    50                  55                  60                  


Val Lys Ser Ile Ser Met Thr Thr Phe Thr Gln Gln Glu Ile Glu Phe 
65                  70                  75                  80  


Leu Gln Lys His Gly Asn Glu Val Cys Lys Gln Ile Trp Leu Gly Leu 
                85                  90                  95      


Phe Asp Asp Arg Ser Ser Ala Ile Pro Asp Phe Arg Asp Pro Gln Lys 
            100                 105                 110         


Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp Tyr Val 
        115                 120                 125             


Pro Pro Glu Gln Ala Lys Val Val Ala Ser Val His Ala Ser Ile Ser 
    130                 135                 140                 


Gly Ser Ser Ala Ser Ser Thr Ser Ser Thr Pro Glu Val Lys Pro Leu 
145                 150                 155                 160 


Lys Ser Leu Leu Gly Asp Ser Ala Pro Thr Leu His Leu Asn Lys Gly 
                165                 170                 175     


Thr Pro Ser Gln Ser Pro Val Val Gly Arg Ser Gln Gly Gln Gln Gln 
            180                 185                 190         


Glu Lys Lys Gln Phe Asp Leu Leu Ser Asp Leu Gly Ser Asp Ile Phe 
        195                 200                 205             


Ala Ala Pro Ala Pro Gln Ser Thr Ala Thr Ala Asn Phe Ala Asn Phe 
    210                 215                 220                 


Ala His Phe Asn Ser His Ala Ala Gln Asn Ser Ala Asn Ala Asp Phe 
225                 230                 235                 240 


Ala Asn Phe Asp Ala Phe Gly Gln Ser Ser Gly Ser Ser Asn Phe Gly 
                245                 250                 255     


Gly Phe Pro Thr Ala Ser His Ser Pro Phe Gln Pro Gln Thr Thr Ala 
            260                 265                 270         


Phe Arg Met Leu Ser Ser Ser Cys Ser Phe Gly Glu Phe Thr Ser Ala 
        275                 280                 285             


Phe Pro Leu Gln Ala Thr His Ser Gly Ser Ala Ala Ser Val Asn Ala 
    290                 295                 300                 


Asn Phe Ala His Phe Asp Asn Phe Pro Lys Ser Ser Ser Ala Asp Phe 
305                 310                 315                 320 


Gly Thr Phe Asn Thr Ser Gln Ser His Gln Thr Ala Ser Ala Val Ser 
                325                 330                 335     


Lys Val Ser Thr Asn Lys Ala Gly Leu Gln Thr Ala Asp Lys Tyr Ala 
            340                 345                 350         


Ala Leu Ala Asn Leu Asp Asn Ile Phe Ser Ala Gly Gln Gly Gly Asp 
        355                 360                 365             


Gln Gly Ser Gly Phe Gly Thr Thr Gly Lys Ala Pro Val Gly Ser Val 
    370                 375                 380                 


Val Ser Val Pro Ser Gln Ser Ser Ala Ser Ser Asp Lys Tyr Ala Ala 
385                 390                 395                 400 


Leu Ala Glu Leu Asp Ser Val Phe Ser Ser Ala Ala Thr Ser Ser Asn 
                405                 410                 415     


Ala Tyr Thr Ser Thr Ser Asn Ala Ser Ser Asn Val Phe Gly Thr Val 
            420                 425                 430         


Pro Val Val Ala Ser Ala Gln Thr Gln Pro Ala Ser Ser Ser Val Pro 
        435                 440                 445             


Ala Pro Phe Gly Ala Thr Pro Ser Thr Asn Pro Phe Val Ala Ala Ala 
    450                 455                 460                 


Gly Pro Ser Val Ala Ser Ser Thr Asn Pro Phe Gln Thr Asn Ala Arg 
465                 470                 475                 480 


Gly Ala Thr Ala Ala Thr Phe Gly Thr Ala Ser Met Ser Met Pro Thr 
                485                 490                 495     


Gly Phe Gly Thr Pro Ala Pro Tyr Ser Leu Pro Thr Ser Phe Ser Gly 
            500                 505                 510         


Ser Phe Gln Gln Pro Ala Phe Pro Ala Gln Ala Ala Phe Pro Gln Gln 
        515                 520                 525             


Thr Ala Phe Ser Gln Gln Pro Asn Gly Phe Ala Ala Phe Gly Gln Thr 
    530                 535                 540                 


Lys Pro Val Val Thr Pro Phe Gly Gln Val Ala Ala Ala Gly Val Ser 
545                 550                 555                 560 


Ser Asn Pro Phe Met Thr Gly Ala Pro Thr Gly Gln Phe Pro Thr Gly 
                565                 570                 575     


Ser Ser Ser Thr Asn Pro Phe Leu 
            580                 


<210>  340
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGFG2__Homo_sapiens__NP_006067

<400>  340

Met Val Met Ala Ala Lys Lys Gly Pro Gly Pro Gly Gly Gly Val Ser 
1               5                   10                  15      


Gly Gly Lys Ala Glu Ala Glu Ala Ala Ser Glu Val Trp Cys Arg Arg 
            20                  25                  30          


Val Arg Glu Leu Gly Gly Cys Ser Gln Ala Gly Asn Arg His Cys Phe 
        35                  40                  45              


Glu Cys Ala Gln Arg Gly Val Thr Tyr Val Asp Ile Thr Val Gly Ser 
    50                  55                  60                  


Phe Val Cys Thr Thr Cys Ser Gly Leu Leu Arg Gly Leu Asn Pro Pro 
65                  70                  75                  80  


His Arg Val Lys Ser Ile Ser Met Thr Thr Phe Thr Glu Pro Glu Val 
                85                  90                  95      


Val Phe Leu Gln Ser Arg Gly Asn Glu Val Cys Arg Lys Ile Trp Leu 
            100                 105                 110         


Gly Leu Phe Asp Ala Arg Thr Ser Leu Val Pro Asp Ser Arg Asp Pro 
        115                 120                 125             


Gln Lys Val Lys Glu Phe Leu Gln Glu Lys Tyr Glu Lys Lys Arg Trp 
    130                 135                 140                 


Tyr Val Pro Pro Asp Gln Val Lys Gly Pro Thr Tyr Thr Lys Gly Ser 
145                 150                 155                 160 


Ala Ser Thr Pro Val Gln Gly Ser Ile Pro Glu Gly Lys Pro Leu Arg 
                165                 170                 175     


Thr Leu Leu Gly Asp Pro Ala Pro Ser Leu Ser Val Ala Ala Ser Thr 
            180                 185                 190         


Ser Ser Gln Pro Val Ser Gln Ser His Ala Arg Thr Ser Gln Ala Arg 
        195                 200                 205             


Ser Thr Gln Pro Pro Pro His Ser Ser Val Lys Lys Ala Ser Thr Asp 
    210                 215                 220                 


Leu Leu Ala Asp Ile Gly Gly Asp Pro Phe Ala Ala Pro Gln Met Ala 
225                 230                 235                 240 


Pro Ala Phe Ala Ala Phe Pro Ala Phe Gly Gly Gln Thr Pro Ser Gln 
                245                 250                 255     


Gly Gly Phe Ala Asn Phe Asp Ala Phe Ser Ser Gly Pro Ser Ser Ser 
            260                 265                 270         


Val Phe Gly Ser Leu Pro Pro Ala Gly Gln Ala Ser Phe Gln Ala Gln 
        275                 280                 285             


Pro Thr Pro Ala Gly Ser Ser Gln Gly Thr Pro Phe Gly Ala Thr Pro 
    290                 295                 300                 


Leu Ala Pro Ala Ser Gln Pro Asn Ser Leu Ala Asp Val Gly Ser Phe 
305                 310                 315                 320 


Leu Gly Pro Gly Val Pro Ala Ala Gly Val Pro Ser Ser Leu Phe Gly 
                325                 330                 335     


Met Ala Gly Gln Val Pro Pro Leu Gln Ser Val Thr Met Gly Gly Gly 
            340                 345                 350         


Gly Gly Ser Ser Thr Gly Leu Ala Phe Gly Ala Phe Thr Asn Pro Phe 
        355                 360                 365             


Thr Ala Pro Ala Ala Gln Ser Pro Leu Pro Ser Thr Asn Pro Phe Gln 
    370                 375                 380                 


Pro Asn Gly Leu Ala Pro Gly Pro Gly Phe Gly Met Ser Ser Ala Gly 
385                 390                 395                 400 


Pro Gly Phe Pro Gln Ala Val Pro Pro Thr Gly Ala Phe Ala Ser Ser 
                405                 410                 415     


Phe Pro Ala Pro Leu Phe Pro Pro Gln Thr Pro Leu Val Gln Gln Gln 
            420                 425                 430         


Asn Gly Ser Ser Phe Gly Asp Leu Gly Ser Ala Lys Leu Gly Gln Arg 
        435                 440                 445             


Pro Leu Ser Gln Pro Ala Gly Ile Ser Thr Asn Pro Phe Met Thr Gly 
    450                 455                 460                 


Pro Ser Ser Ser Pro Phe Ala Ser Lys Pro Pro Thr Thr Asn Pro Phe 
465                 470                 475                 480 


Leu 
    


<210>  341
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGGF1__Homo_sapiens__NP_060516

<400>  341

Met Ala Ser Glu Ala Pro Ser Pro Pro Arg Ser Pro Pro Pro Pro Thr 
1               5                   10                  15      


Ser Pro Glu Pro Glu Leu Ala Gln Leu Arg Arg Lys Val Glu Lys Leu 
            20                  25                  30          


Glu Arg Glu Leu Arg Ser Cys Lys Arg Gln Val Arg Glu Ile Glu Lys 
        35                  40                  45              


Leu Leu His His Thr Glu Arg Leu Tyr Gln Asn Ala Glu Ser Asn Asn 
    50                  55                  60                  


Gln Glu Leu Arg Thr Gln Val Glu Glu Leu Ser Lys Ile Leu Gln Arg 
65                  70                  75                  80  


Gly Arg Asn Glu Asp Asn Lys Lys Ser Asp Val Glu Val Gln Thr Glu 
                85                  90                  95      


Asn His Ala Pro Trp Ser Ile Ser Asp Tyr Phe Tyr Gln Thr Tyr Tyr 
            100                 105                 110         


Asn Asp Val Ser Leu Pro Asn Lys Val Thr Glu Leu Ser Asp Gln Gln 
        115                 120                 125             


Asp Gln Ala Ile Glu Thr Ser Ile Leu Asn Ser Lys Asp His Leu Gln 
    130                 135                 140                 


Val Glu Asn Asp Ala Tyr Pro Gly Thr Asp Arg Thr Glu Asn Val Lys 
145                 150                 155                 160 


Tyr Arg Gln Val Asp His Phe Ala Ser Asn Ser Gln Glu Pro Ala Ser 
                165                 170                 175     


Ala Leu Ala Thr Glu Asp Thr Ser Leu Glu Gly Ser Ser Leu Ala Glu 
            180                 185                 190         


Ser Leu Arg Ala Ala Ala Glu Ala Ala Val Ser Gln Thr Gly Phe Ser 
        195                 200                 205             


Tyr Asp Glu Asn Thr Gly Leu Tyr Phe Asp His Ser Thr Gly Phe Tyr 
    210                 215                 220                 


Tyr Asp Ser Glu Asn Gln Leu Tyr Tyr Asp Pro Ser Thr Gly Ile Tyr 
225                 230                 235                 240 


Tyr Tyr Cys Asp Val Glu Ser Gly Arg Tyr Gln Phe His Ser Arg Val 
                245                 250                 255     


Asp Leu Gln Pro Tyr Pro Thr Ser Ser Thr Lys Gln Ser Lys Asp Lys 
            260                 265                 270         


Lys Leu Lys Lys Lys Arg Lys Asp Pro Asp Ser Ser Ala Thr Asn Glu 
        275                 280                 285             


Glu Lys Asp Leu Asn Ser Glu Asp Gln Lys Ala Phe Ser Val Glu His 
    290                 295                 300                 


Thr Ser Cys Asn Glu Glu Glu Asn Phe Ala Asn Met Lys Lys Lys Ala 
305                 310                 315                 320 


Lys Ile Gly Ile His His Lys Asn Ser Pro Pro Lys Val Thr Val Pro 
                325                 330                 335     


Thr Ser Gly Asn Thr Ile Glu Ser Pro Leu His Glu Asn Ile Ser Asn 
            340                 345                 350         


Ser Thr Ser Phe Lys Asp Glu Lys Ile Met Glu Thr Asp Ser Glu Pro 
        355                 360                 365             


Glu Glu Gly Glu Ile Thr Asp Ser Gln Thr Glu Asp Ser Tyr Asp Glu 
    370                 375                 380                 


Ala Ile Thr Ser Glu Gly Asn Val Thr Ala Glu Asp Ser Glu Asp Glu 
385                 390                 395                 400 


Asp Glu Asp Lys Ile Trp Pro Pro Cys Ile Arg Val Ile Val Ile Arg 
                405                 410                 415     


Ser Pro Val Leu Gln Ile Gly Ser Leu Phe Ile Ile Thr Ala Val Asn 
            420                 425                 430         


Pro Ala Thr Ile Gly Arg Glu Lys Asp Met Glu His Thr Leu Arg Ile 
        435                 440                 445             


Pro Glu Val Gly Val Ser Lys Phe His Ala Glu Ile Tyr Phe Asp His 
    450                 455                 460                 


Asp Leu Gln Ser Tyr Val Leu Val Asp Gln Gly Ser Gln Asn Gly Thr 
465                 470                 475                 480 


Ile Val Asn Gly Lys Gln Ile Leu Gln Pro Lys Thr Lys Cys Asp Pro 
                485                 490                 495     


Tyr Val Leu Glu His Gly Asp Glu Val Lys Ile Gly Glu Thr Val Leu 
            500                 505                 510         


Ser Phe His Ile His Pro Gly Ser Asp Thr Cys Asp Gly Cys Glu Pro 
        515                 520                 525             


Gly Gln Val Arg Ala His Leu Arg Leu Asp Lys Lys Asp Glu Ser Phe 
    530                 535                 540                 


Val Gly Pro Thr Leu Ser Lys Glu Glu Lys Glu Leu Glu Arg Arg Lys 
545                 550                 555                 560 


Glu Leu Lys Lys Ile Arg Val Lys Tyr Gly Leu Gln Asn Thr Glu Tyr 
                565                 570                 575     


Glu Asp Glu Lys Thr Leu Lys Asn Pro Lys Tyr Lys Asp Arg Ala Gly 
            580                 585                 590         


Lys Arg Arg Glu Gln Val Gly Ser Glu Gly Thr Phe Gln Arg Asp Asp 
        595                 600                 605             


Ala Pro Ala Ser Val His Ser Glu Ile Thr Asp Ser Asn Lys Gly Arg 
    610                 615                 620                 


Lys Met Leu Glu Lys Met Gly Trp Lys Lys Gly Glu Gly Leu Gly Lys 
625                 630                 635                 640 


Asp Gly Gly Gly Met Lys Thr Pro Ile Gln Leu Gln Leu Arg Arg Thr 
                645                 650                 655     


His Ala Gly Leu Gly Thr Gly Lys Pro Ser Ser Phe Glu Asp Val His 
            660                 665                 670         


Leu Leu Gln Asn Lys Asn Lys Lys Asn Trp Asp Lys Ala Arg Glu Arg 
        675                 680                 685             


Phe Thr Glu Asn Phe Pro Glu Thr Lys Pro Gln Lys Asp Asp Pro Gly 
    690                 695                 700                 


Thr Met Pro Trp Val Lys Gly Thr Leu Glu 
705                 710                 


<210>  342
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGK__Homo_sapiens__XP_005250080

<400>  342

Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr 
1               5                   10                  15      


Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly Lys 
            20                  25                  30          


His Cys Asp Asn Leu Leu Arg Arg Ala Ala Cys Gln Glu Ala Gln Val 
        35                  40                  45              


Phe Gly Asn Gln Leu Ile Pro Pro Asn Ala Gln Val Lys Lys Ala Thr 
    50                  55                  60                  


Val Phe Leu Asn Pro Ala Ala Cys Lys Gly Lys Ala Arg Thr Leu Phe 
65                  70                  75                  80  


Glu Lys Asn Ala Ala Pro Ile Leu His Leu Ser Gly Met Asp Val Thr 
                85                  90                  95      


Ile Val Lys Thr Asp Tyr Glu Gly Gln Ala Lys Lys Leu Leu Glu Leu 
            100                 105                 110         


Met Glu Asn Thr Asp Val Ile Ile Val Ala Gly Gly Asp Gly Thr Leu 
        115                 120                 125             


Gln Glu Val Val Thr Gly Val Leu Arg Arg Thr Asp Glu Ala Thr Phe 
    130                 135                 140                 


Ser Lys Ile Pro Ile Gly Phe Ile Pro Leu Gly Glu Thr Ser Ser Leu 
145                 150                 155                 160 


Ser His Thr Leu Phe Ala Glu Ser Gly Asn Lys Val Gln His Ile Thr 
                165                 170                 175     


Asp Ala Thr Leu Ala Ile Val Lys Gly Glu Thr Val Pro Leu Asp Val 
            180                 185                 190         


Leu Gln Ile Lys Gly Glu Lys Glu Gln Pro Val Phe Ala Met Thr Gly 
        195                 200                 205             


Leu Arg Trp Gly Ser Phe Arg Asp Ala Gly Val Lys Val Ser Lys Tyr 
    210                 215                 220                 


Trp Tyr Leu Gly Pro Leu Lys Ile Lys Ala Ala His Phe Phe Ser Thr 
225                 230                 235                 240 


Leu Lys Glu Trp Pro Gln Thr His Gln Ala Ser Ile Ser Tyr Thr Gly 
                245                 250                 255     


Pro Thr Glu Arg Pro Pro Asn Glu Pro Glu Glu Thr Pro Val Gln Arg 
            260                 265                 270         


Pro Ser Leu Tyr Arg Arg Ile Leu Arg Arg Leu Ala Ser Tyr Trp Ala 
        275                 280                 285             


Gln Pro Gln Asp Ala Leu Ser Gln Glu Val Ser Pro Glu Val Trp Lys 
    290                 295                 300                 


Asp Val Gln Leu Ser Thr Ile Glu Leu Ser Ile Thr Thr Arg Asn Asn 
305                 310                 315                 320 


Gln Leu Asp Pro Thr Ser Lys Glu Asp Phe Leu Asn Ile Cys Ile Glu 
                325                 330                 335     


Pro Asp Thr Ile Ser Lys Gly Asp Phe Ile Thr Ile Gly Lys 
            340                 345                 350 


<210>  343
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGMO__Homo_sapiens__NP_001004320

<400>  343

Met Lys Asn Pro Glu Ala Gln Gln Asp Val Ser Val Ser Gln Gly Phe 
1               5                   10                  15      


Arg Met Leu Phe Tyr Thr Met Lys Pro Ser Glu Thr Ser Phe Gln Thr 
            20                  25                  30          


Leu Glu Glu Val Pro Asp Tyr Val Lys Lys Ala Thr Pro Phe Phe Ile 
        35                  40                  45              


Ser Leu Met Leu Leu Glu Leu Val Val Ser Trp Ile Leu Lys Gly Lys 
    50                  55                  60                  


Pro Pro Gly Arg Leu Asp Asp Ala Leu Thr Ser Ile Ser Ala Gly Val 
65                  70                  75                  80  


Leu Ser Arg Leu Pro Ser Leu Phe Phe Arg Ser Ile Glu Leu Thr Ser 
                85                  90                  95      


Tyr Ile Tyr Ile Trp Glu Asn Tyr Arg Leu Phe Asn Leu Pro Trp Asp 
            100                 105                 110         


Ser Pro Trp Thr Trp Tyr Ser Ala Phe Leu Gly Val Asp Phe Gly Tyr 
        115                 120                 125             


Tyr Trp Phe His Arg Met Ala His Glu Val Asn Ile Met Trp Ala Gly 
    130                 135                 140                 


His Gln Thr His His Ser Ser Glu Asp Tyr Asn Leu Ser Thr Ala Leu 
145                 150                 155                 160 


Arg Gln Ser Val Leu Gln Ile Tyr Thr Ser Trp Ile Phe Tyr Ser Pro 
                165                 170                 175     


Leu Ala Leu Phe Ile Pro Pro Ser Val Tyr Ala Val His Leu Gln Phe 
            180                 185                 190         


Asn Leu Leu Tyr Gln Phe Trp Ile His Thr Glu Val Ile Asn Asn Leu 
        195                 200                 205             


Gly Pro Leu Glu Leu Ile Leu Asn Thr Pro Ser His His Arg Val His 
    210                 215                 220                 


His Gly Arg Asn Arg Tyr Cys Ile Asp Lys Asn Tyr Ala Gly Val Leu 
225                 230                 235                 240 


Ile Ile Trp Asp Lys Ile Phe Gly Thr Phe Glu Ala Glu Asn Glu Lys 
                245                 250                 255     


Val Val Tyr Gly Leu Thr His Pro Ile Asn Thr Phe Glu Pro Ile Lys 
            260                 265                 270         


Val Gln Phe His His Leu Phe Ser Ile Trp Thr Thr Phe Trp Ala Thr 
        275                 280                 285             


Pro Gly Phe Phe Asn Lys Phe Ser Val Ile Phe Lys Gly Pro Gly Trp 
    290                 295                 300                 


Gly Pro Gly Lys Pro Arg Leu Gly Leu Ser Glu Glu Ile Pro Glu Val 
305                 310                 315                 320 


Thr Gly Lys Glu Val Pro Phe Ser Ser Ser Ser Ser Gln Leu Leu Lys 
                325                 330                 335     


Ile Tyr Thr Val Val Gln Phe Ala Leu Met Leu Ala Phe Tyr Glu Glu 
            340                 345                 350         


Thr Phe Ala Asp Thr Ala Ala Leu Ser Gln Val Thr Leu Leu Leu Arg 
        355                 360                 365             


Val Cys Phe Ile Ile Leu Thr Leu Thr Ser Ile Gly Phe Leu Leu Asp 
    370                 375                 380                 


Gln Arg Pro Lys Ala Ala Ile Met Glu Thr Leu Arg Cys Leu Met Phe 
385                 390                 395                 400 


Leu Met Leu Tyr Arg Phe Gly His Leu Lys Pro Leu Val Pro Ser Leu 
                405                 410                 415     


Ser Ser Ala Phe Glu Ile Val Phe Ser Ile Cys Ile Ala Phe Trp Gly 
            420                 425                 430         


Val Arg Ser Met Lys Gln Leu Thr Ser His Pro Trp Lys 
        435                 440                 445 


<210>  344
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGO2__Homo_sapiens__NP_001158095

<400>  344

Met Tyr Ser Gly Ala Gly Pro Ala Leu Ala Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      


Pro Ile Gln Gly Tyr Ala Phe Lys Pro Pro Pro Arg Pro Asp Phe Gly 
            20                  25                  30          


Thr Ser Gly Arg Thr Ile Lys Leu Gln Ala Asn Phe Phe Glu Met Asp 
        35                  40                  45              


Ile Pro Lys Ile Asp Ile Tyr His Tyr Glu Leu Asp Ile Lys Pro Glu 
    50                  55                  60                  


Lys Cys Pro Arg Arg Val Asn Arg Glu Ile Val Glu His Met Val Gln 
65                  70                  75                  80  


His Phe Lys Thr Gln Ile Phe Gly Asp Arg Lys Pro Val Phe Asp Gly 
                85                  90                  95      


Arg Lys Asn Leu Tyr Thr Ala Met Pro Leu Pro Ile Gly Arg Asp Lys 
            100                 105                 110         


Val Glu Leu Glu Val Thr Leu Pro Gly Glu Gly Lys Asp Arg Ile Phe 
        115                 120                 125             


Lys Val Ser Ile Lys Trp Val Ser Cys Val Ser Leu Gln Ala Leu His 
    130                 135                 140                 


Asp Ala Leu Ser Gly Arg Leu Pro Ser Val Pro Phe Glu Thr Ile Gln 
145                 150                 155                 160 


Ala Leu Asp Val Val Met Arg His Leu Pro Ser Met Arg Tyr Thr Pro 
                165                 170                 175     


Val Gly Arg Ser Phe Phe Thr Ala Ser Glu Gly Cys Ser Asn Pro Leu 
            180                 185                 190         


Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro 
        195                 200                 205             


Ser Leu Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe 
    210                 215                 220                 


Tyr Lys Ala Gln Pro Val Ile Glu Phe Val Cys Glu Val Leu Asp Phe 
225                 230                 235                 240 


Lys Ser Ile Glu Glu Gln Gln Lys Pro Leu Thr Asp Ser Gln Arg Val 
                245                 250                 255     


Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Ile Thr His Cys 
            260                 265                 270         


Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro 
        275                 280                 285             


Ala Ser His Gln Thr Phe Pro Leu Gln Gln Glu Ser Gly Gln Thr Val 
    290                 295                 300                 


Glu Cys Thr Val Ala Gln Tyr Phe Lys Asp Arg His Lys Leu Val Leu 
305                 310                 315                 320 


Arg Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His 
                325                 330                 335     


Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys 
            340                 345                 350         


Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Arg Ala Thr 
        355                 360                 365             


Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Lys Leu Met Arg 
    370                 375                 380                 


Ser Ala Ser Phe Asn Thr Asp Pro Tyr Val Arg Glu Phe Gly Ile Met 
385                 390                 395                 400 


Val Lys Asp Glu Met Thr Asp Val Thr Gly Arg Val Leu Gln Pro Pro 
                405                 410                 415     


Ser Ile Leu Tyr Gly Gly Arg Asn Lys Ala Ile Ala Thr Pro Val Gln 
            420                 425                 430         


Gly Val Trp Asp Met Arg Asn Lys Gln Phe His Thr Gly Ile Glu Ile 
        435                 440                 445             


Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Arg Gln Cys Thr Glu 
    450                 455                 460                 


Val His Leu Lys Ser Phe Thr Glu Gln Leu Arg Lys Ile Ser Arg Asp 
465                 470                 475                 480 


Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln 
                485                 490                 495     


Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr 
            500                 505                 510         


Ala Gly Leu Gln Leu Val Val Val Ile Leu Pro Gly Lys Thr Pro Val 
        515                 520                 525             


Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Val Leu Gly Met Ala Thr 
    530                 535                 540                 


Gln Cys Val Gln Met Lys Asn Val Gln Arg Thr Thr Pro Gln Thr Leu 
545                 550                 555                 560 


Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Val Asn Asn 
                565                 570                 575     


Ile Leu Leu Pro Gln Gly Arg Pro Pro Val Phe Gln Gln Pro Val Ile 
            580                 585                 590         


Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys 
        595                 600                 605             


Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Asn Arg 
    610                 615                 620                 


Tyr Cys Ala Thr Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln 
625                 630                 635                 640 


Asp Leu Ala Ala Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser 
                645                 650                 655     


Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Ser 
            660                 665                 670         


Glu Gly Gln Phe Gln Gln Val Leu His His Glu Leu Leu Ala Ile Arg 
        675                 680                 685             


Glu Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Phe 
    690                 695                 700                 


Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Thr Asp Lys 
705                 710                 715                 720 


Asn Glu Arg Gly Thr Ser Arg Pro Ser His Tyr His Val Leu Trp Asp 
                725                 730                 735     


Asp Asn Arg Phe Ser Ser Asp Glu Leu Gln Ile Leu Thr Tyr Gln Leu 
            740                 745                 750         


Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro Ala Pro 
        755                 760                 765             


Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val 
    770                 775                 780                 


Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Thr Ser Gly Gln Ser 
785                 790                 795                 800 


Asn Gly Arg Asp His Gln Ala Leu Ala Lys Ala Val Gln Val His Gln 
                805                 810                 815     


Asp Thr Leu Arg Thr Met Tyr Phe Ala 
            820                 825 


<210>  345
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGPAT1__Homo_sapiens__XP_005248862

<400>  345

Met Val Ala Arg Met Asp Leu Trp Pro Gly Ala Trp Met Leu Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Leu Leu Leu Phe Leu Leu Pro Thr Leu Trp Phe Cys 
            20                  25                  30          


Ser Pro Ser Ala Lys Tyr Phe Phe Lys Met Ala Phe Tyr Asn Gly Trp 
        35                  40                  45              


Ile Leu Phe Leu Ala Val Leu Ala Ile Pro Val Cys Ala Val Arg Gly 
    50                  55                  60                  


Arg Asn Val Glu Asn Met Lys Ile Leu Arg Leu Met Leu Leu His Ile 
65                  70                  75                  80  


Lys Tyr Leu Tyr Gly Ile Arg Val Glu Val Arg Gly Ala His His Phe 
                85                  90                  95      


Pro Pro Ser Gln Pro Tyr Val Val Val Ser Asn His Gln Ser Ser Leu 
            100                 105                 110         


Asp Leu Leu Gly Met Met Glu Val Leu Pro Gly Arg Cys Val Pro Ile 
        115                 120                 125             


Ala Lys Arg Glu Leu Leu Trp Ala Gly Ser Ala Gly Leu Ala Cys Trp 
    130                 135                 140                 


Leu Ala Gly Val Ile Phe Ile Asp Arg Lys Arg Thr Gly Asp Ala Ile 
145                 150                 155                 160 


Ser Val Met Ser Glu Val Ala Gln Thr Leu Leu Thr Gln Asp Val Arg 
                165                 170                 175     


Val Trp Val Phe Pro Glu Gly Thr Arg Asn His Asn Gly Ser Met Leu 
            180                 185                 190         


Pro Phe Lys Arg Gly Ala Phe His Leu Ala Val Gln Ala Gln Val Pro 
        195                 200                 205             


Ile Val Pro Ile Val Met Ser Ser Tyr Gln Asp Phe Tyr Cys Lys Lys 
    210                 215                 220                 


Glu Arg Arg Phe Thr Ser Gly Gln Cys Gln Val Arg Val Leu Pro Pro 
225                 230                 235                 240 


Val Pro Thr Glu Gly Leu Thr Pro Asp Asp Val Pro Ala Leu Ala Asp 
                245                 250                 255     


Arg Val Arg His Ser Met Leu Thr Val Phe Arg Glu Ile Ser Thr Asp 
            260                 265                 270         


Gly Arg Gly Gly Gly Asp Tyr Leu Lys Lys Pro Gly Gly Gly Gly 
        275                 280                 285         


<210>  346
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGPAT2__Homo_sapiens__NP_001012745

<400>  346

Met Glu Leu Trp Pro Cys Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Gln Leu Ser Arg Ala Ala Glu Phe Tyr Ala Lys Val Ala Leu 
            20                  25                  30          


Tyr Cys Ala Leu Cys Phe Thr Val Ser Ala Val Ala Ser Leu Val Cys 
        35                  40                  45              


Leu Leu Arg His Gly Gly Arg Thr Val Glu Asn Met Ser Ile Ile Gly 
    50                  55                  60                  


Trp Phe Val Arg Ser Phe Lys Tyr Phe Tyr Gly Leu Arg Phe Glu Val 
65                  70                  75                  80  


Arg Asp Pro Arg Arg Leu Gln Glu Ala Arg Pro Cys Val Ile Val Ser 
                85                  90                  95      


Asn His Gln Ser Ile Leu Asp Met Met Gly Leu Met Glu Val Leu Pro 
            100                 105                 110         


Glu Arg Cys Val Gln Ile Ala Lys Arg Glu Leu Leu Phe Leu Gly Pro 
        115                 120                 125             


Val Gly Leu Ile Met Tyr Leu Gly Gly Val Phe Phe Ile Asn Arg Gln 
    130                 135                 140                 


Arg Ser Ser Thr Ala Met Thr Val Met Ala Asp Leu Gly Glu Arg Met 
145                 150                 155                 160 


Val Arg Glu Asn Val Pro Ile Val Pro Val Val Tyr Ser Ser Phe Ser 
                165                 170                 175     


Ser Phe Tyr Asn Thr Lys Lys Lys Phe Phe Thr Ser Gly Thr Val Thr 
            180                 185                 190         


Val Gln Val Leu Glu Ala Ile Pro Thr Ser Gly Leu Thr Ala Ala Asp 
        195                 200                 205             


Val Pro Ala Leu Val Asp Thr Cys His Arg Ala Met Arg Thr Thr Phe 
    210                 215                 220                 


Leu His Ile Ser Lys Thr Pro Gln Glu Asn Gly Ala Thr Ala Gly Ser 
225                 230                 235                 240 


Gly Val Gln Pro Ala Gln 
                245     


<210>  347
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGPAT3__Homo_sapiens__XP_006724093

<400>  347

Met Gly Leu Leu Ala Phe Leu Lys Thr Gln Phe Val Leu His Leu Leu 
1               5                   10                  15      


Val Gly Phe Val Phe Val Val Ser Gly Leu Val Ile Asn Phe Val Gln 
            20                  25                  30          


Leu Cys Thr Leu Ala Leu Trp Pro Val Ser Lys Gln Leu Tyr Arg Arg 
        35                  40                  45              


Leu Asn Cys Arg Leu Ala Tyr Ser Leu Trp Ser Gln Leu Val Met Leu 
    50                  55                  60                  


Leu Glu Trp Trp Ser Cys Thr Glu Cys Thr Leu Phe Thr Asp Gln Ala 
65                  70                  75                  80  


Thr Val Glu Arg Phe Gly Lys Glu His Ala Val Ile Ile Leu Asn His 
                85                  90                  95      


Asn Phe Glu Ile Asp Phe Leu Cys Gly Trp Thr Met Cys Glu Arg Phe 
            100                 105                 110         


Gly Val Leu Gly Ser Ser Lys Val Leu Ala Lys Lys Glu Leu Leu Tyr 
        115                 120                 125             


Val Pro Leu Ile Gly Trp Thr Trp Tyr Phe Leu Glu Ile Val Phe Cys 
    130                 135                 140                 


Lys Arg Lys Trp Glu Glu Asp Arg Asp Thr Val Val Glu Gly Leu Arg 
145                 150                 155                 160 


Arg Leu Ser Asp Tyr Pro Glu Tyr Met Trp Phe Leu Leu Tyr Cys Glu 
                165                 170                 175     


Gly Thr Arg Phe Thr Glu Thr Lys His Arg Val Ser Met Glu Val Ala 
            180                 185                 190         


Ala Ala Lys Gly Leu Pro Val Leu Lys Tyr His Leu Leu Pro Arg Thr 
        195                 200                 205             


Lys Gly Phe Thr Thr Ala Val Lys Cys Leu Arg Gly Thr Val Ala Ala 
    210                 215                 220                 


Val Tyr Asp Val Thr Leu Asn Phe Arg Gly Asn Lys Asn Pro Ser Leu 
225                 230                 235                 240 


Leu Gly Ile Leu Tyr Gly Lys Lys Tyr Glu Ala Asp Met Cys Val Arg 
                245                 250                 255     


Arg Phe Pro Leu Glu Asp Ile Pro Leu Asp Glu Lys Glu Ala Ala Gln 
            260                 265                 270         


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Leu Gln Glu Ile Tyr 
        275                 280                 285             


Asn Gln Lys Gly Met Phe Pro Gly Glu Gln Phe Lys Pro Ala Arg Arg 
    290                 295                 300                 


Pro Trp Thr Leu Leu Asn Phe Leu Ser Trp Ala Thr Ile Leu Leu Ser 
305                 310                 315                 320 


Pro Leu Phe Ser Phe Val Leu Gly Val Phe Ala Ser Gly Ser Pro Leu 
                325                 330                 335     


Leu Ile Leu Thr Phe Leu Gly Phe Val Gly Ala Ala Ser Phe Gly Val 
            340                 345                 350         


Arg Arg Leu Ile Gly Val Thr Glu Ile Glu Lys Gly Ser Ser Tyr Gly 
        355                 360                 365             


Asn Gln Glu Phe Lys Lys Lys Glu 
    370                 375     


<210>  348
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGPAT4__Homo_sapiens__NP_064518

<400>  348

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15      


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30          


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45              


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60                  


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80  


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95      


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110         


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125             


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140                 


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160 


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175     


Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190         


Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205             


Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220                 


Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240 


Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255     


Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270         


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285             


Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300                 


Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320 


Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335     


Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350         


Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365             


Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375             


<210>  349
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGPAT9__Homo_sapiens__NP_001243350

<400>  349

Met Glu Gly Ala Glu Leu Ala Gly Lys Ile Leu Ser Thr Trp Leu Thr 
1               5                   10                  15      


Leu Val Leu Gly Phe Ile Leu Leu Pro Ser Val Phe Gly Val Ser Leu 
            20                  25                  30          


Gly Ile Ser Glu Ile Tyr Met Lys Ile Leu Val Lys Thr Leu Glu Trp 
        35                  40                  45              


Ala Thr Ile Arg Ile Glu Lys Gly Thr Pro Lys Glu Ser Ile Leu Lys 
    50                  55                  60                  


Asn Ser Ala Ser Val Gly Ile Ile Gln Arg Asp Glu Ser Pro Met Glu 
65                  70                  75                  80  


Lys Gly Leu Ser Gly Leu Arg Gly Arg Asp Phe Glu Leu Ser Asp Val 
                85                  90                  95      


Phe Tyr Phe Ser Lys Lys Gly Leu Glu Ala Ile Val Glu Asp Glu Val 
            100                 105                 110         


Thr Gln Arg Phe Ser Ser Glu Glu Leu Val Ser Trp Asn Leu Leu Thr 
        115                 120                 125             


Arg Thr Asn Val Asn Phe Gln Tyr Ile Ser Leu Arg Leu Thr Met Val 
    130                 135                 140                 


Trp Val Leu Gly Val Ile Val Arg Tyr Cys Val Leu Leu Pro Leu Arg 
145                 150                 155                 160 


Val Thr Leu Ala Phe Ile Gly Ile Ser Leu Leu Val Ile Gly Thr Thr 
                165                 170                 175     


Leu Val Gly Gln Leu Pro Asp Ser Ser Leu Lys Asn Trp Leu Ser Glu 
            180                 185                 190         


Leu Val His Leu Thr Cys Cys Arg Ile Cys Val Arg Ala Leu Ser Gly 
        195                 200                 205             


Thr Ile His Tyr His Asn Lys Gln Tyr Arg Pro Gln Lys Gly Gly Ile 
    210                 215                 220                 


Cys Val Ala Asn His Thr Ser Pro Ile Asp Val Leu Ile Leu Thr Thr 
225                 230                 235                 240 


Asp Gly Cys Tyr Ala Met Val Gly Gln Val His Gly Gly Leu Met Gly 
                245                 250                 255     


Ile Ile Gln Arg Ala Met Val Lys Ala Cys Pro His Val Trp Phe Glu 
            260                 265                 270         


Arg Ser Glu Met Lys Asp Arg His Leu Val Thr Lys Arg Leu Lys Glu 
        275                 280                 285             


His Ile Ala Asp Lys Lys Lys Leu Pro Ile Leu Ile Phe Pro Glu Gly 
    290                 295                 300                 


Thr Cys Ile Asn Asn Thr Ser Val Met Met Phe Lys Lys Gly Ser Phe 
305                 310                 315                 320 


Glu Ile Gly Gly Thr Ile His Pro Val Ala Ile Lys Tyr Asn Pro Gln 
                325                 330                 335     


Phe Gly Asp Ala Phe Trp Asn Ser Ser Lys Tyr Asn Met Val Ser Tyr 
            340                 345                 350         


Leu Leu Arg Met Met Thr Ser Trp Ala Ile Val Cys Asp Val Trp Tyr 
        355                 360                 365             


Met Pro Pro Met Thr Arg Glu Glu Gly Glu Asp Ala Val Gln Phe Ala 
    370                 375                 380                 


Asn Arg Val Lys Ser Ala Ile Ala Ile Gln Gly Gly Leu Thr Glu Leu 
385                 390                 395                 400 


Pro Trp Asp Gly Gly Leu Lys Arg Ala Lys Val Lys Asp Ile Phe Lys 
                405                 410                 415     


Glu Glu Gln Gln Lys Asn Tyr Ser Lys Met Ile Val Gly Asn Gly Ser 
            420                 425                 430         


Leu Ser 
        


<210>  350
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGPS__Homo_sapiens__NP_003650

<400>  350

Met Ala Glu Ala Ala Ala Ala Ala Gly Gly Thr Gly Leu Gly Ala Gly 
1               5                   10                  15      


Ala Ser Tyr Gly Ser Ala Ala Asp Arg Asp Arg Asp Pro Asp Pro Asp 
            20                  25                  30          


Arg Ala Gly Arg Arg Leu Arg Val Leu Ser Gly His Leu Leu Gly Arg 
        35                  40                  45              


Pro Arg Glu Ala Leu Ser Thr Asn Glu Cys Lys Ala Arg Arg Ala Ala 
    50                  55                  60                  


Ser Ala Ala Thr Ala Ala Pro Thr Ala Thr Pro Ala Ala Gln Glu Ser 
65                  70                  75                  80  


Gly Thr Ile Pro Lys Lys Arg Gln Glu Val Met Lys Trp Asn Gly Trp 
                85                  90                  95      


Gly Tyr Asn Asp Ser Lys Phe Ile Phe Asn Lys Lys Gly Gln Ile Glu 
            100                 105                 110         


Leu Thr Gly Lys Arg Tyr Pro Leu Ser Gly Met Gly Leu Pro Thr Phe 
        115                 120                 125             


Lys Glu Trp Ile Gln Asn Thr Leu Gly Val Asn Val Glu His Lys Thr 
    130                 135                 140                 


Thr Ser Lys Ala Ser Leu Asn Pro Ser Asp Thr Pro Pro Ser Val Val 
145                 150                 155                 160 


Asn Glu Asp Phe Leu His Asp Leu Lys Glu Thr Asn Ile Ser Tyr Ser 
                165                 170                 175     


Gln Glu Ala Asp Asp Arg Val Phe Arg Ala His Gly His Cys Leu His 
            180                 185                 190         


Glu Ile Phe Leu Leu Arg Glu Gly Met Phe Glu Arg Ile Pro Asp Ile 
        195                 200                 205             


Val Leu Trp Pro Thr Cys His Asp Asp Val Val Lys Ile Val Asn Leu 
    210                 215                 220                 


Ala Cys Lys Tyr Asn Leu Cys Ile Ile Pro Ile Gly Gly Gly Thr Ser 
225                 230                 235                 240 


Val Ser Tyr Gly Leu Met Cys Pro Ala Asp Glu Thr Arg Thr Ile Ile 
                245                 250                 255     


Ser Leu Asp Thr Ser Gln Met Asn Arg Ile Leu Trp Val Asp Glu Asn 
            260                 265                 270         


Asn Leu Thr Ala His Val Glu Ala Gly Ile Thr Gly Gln Glu Leu Glu 
        275                 280                 285             


Arg Gln Leu Lys Glu Ser Gly Tyr Cys Thr Gly His Glu Pro Asp Ser 
    290                 295                 300                 


Leu Glu Phe Ser Thr Val Gly Gly Trp Val Ser Thr Arg Ala Ser Gly 
305                 310                 315                 320 


Met Lys Lys Asn Ile Tyr Gly Asn Ile Glu Asp Leu Val Val His Ile 
                325                 330                 335     


Lys Met Val Thr Pro Arg Gly Ile Ile Glu Lys Ser Cys Gln Gly Pro 
            340                 345                 350         


Arg Met Ser Thr Gly Pro Asp Ile His His Phe Ile Met Gly Ser Glu 
        355                 360                 365             


Gly Thr Leu Gly Val Ile Thr Glu Ala Thr Ile Lys Ile Arg Pro Val 
    370                 375                 380                 


Pro Glu Tyr Gln Lys Tyr Gly Ser Val Ala Phe Pro Asn Phe Glu Gln 
385                 390                 395                 400 


Gly Val Ala Cys Leu Arg Glu Ile Ala Lys Gln Arg Cys Ala Pro Ala 
                405                 410                 415     


Ser Ile Arg Leu Met Asp Asn Lys Gln Phe Gln Phe Gly His Ala Leu 
            420                 425                 430         


Lys Pro Gln Val Ser Ser Ile Phe Thr Ser Phe Leu Asp Gly Leu Lys 
        435                 440                 445             


Lys Phe Tyr Ile Thr Lys Phe Lys Gly Phe Asp Pro Asn Gln Leu Ser 
    450                 455                 460                 


Val Ala Thr Leu Leu Phe Glu Gly Asp Arg Glu Lys Val Leu Gln His 
465                 470                 475                 480 


Glu Lys Gln Val Tyr Asp Ile Ala Ala Lys Phe Gly Gly Leu Ala Ala 
                485                 490                 495     


Gly Glu Asp Asn Gly Gln Arg Gly Tyr Leu Leu Thr Tyr Val Ile Ala 
            500                 505                 510         


Tyr Ile Arg Asp Leu Ala Leu Glu Tyr Tyr Val Leu Gly Glu Ser Phe 
        515                 520                 525             


Glu Thr Ser Ala Pro Trp Asp Arg Val Val Asp Leu Cys Arg Asn Val 
    530                 535                 540                 


Lys Glu Arg Ile Thr Arg Glu Cys Lys Glu Lys Gly Val Gln Phe Ala 
545                 550                 555                 560 


Pro Phe Ser Thr Cys Arg Val Thr Gln Thr Tyr Asp Ala Gly Ala Cys 
                565                 570                 575     


Ile Tyr Phe Tyr Phe Ala Phe Asn Tyr Arg Gly Ile Ser Asp Pro Leu 
            580                 585                 590         


Thr Val Phe Glu Gln Thr Glu Ala Ala Ala Arg Glu Glu Ile Leu Ala 
        595                 600                 605             


Asn Gly Gly Ser Leu Ser His His His Gly Val Gly Lys Leu Arg Lys 
    610                 615                 620                 


Gln Trp Leu Lys Glu Ser Ile Ser Asp Val Gly Phe Gly Met Leu Lys 
625                 630                 635                 640 


Ser Val Lys Glu Tyr Val Asp Pro Asn Asn Ile Phe Gly Asn Arg Asn 
                645                 650                 655     


Leu Leu 
        


<210>  351
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGR2__Homo_sapiens__NP_006399

<400>  351

Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser 
1               5                   10                  15      


Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp 
            20                  25                  30          


Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp 
        35                  40                  45              


Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys 
    50                  55                  60                  


Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu 
65                  70                  75                  80  


Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu 
                85                  90                  95      


Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu 
            100                 105                 110         


Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile 
        115                 120                 125             


Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg 
    130                 135                 140                 


Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu 
145                 150                 155                 160 


Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu 
                165                 170                 175 


<210>  352
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGR3__Homo_sapiens__NP_789783

<400>  352

Met Met Leu His Ser Ala Leu Gly Leu Cys Leu Leu Leu Val Thr Val 
1               5                   10                  15      


Ser Ser Asn Leu Ala Ile Ala Ile Lys Lys Glu Lys Arg Pro Pro Gln 
            20                  25                  30          


Thr Leu Ser Arg Gly Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr 
        35                  40                  45              


Glu Glu Gly Leu Phe Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val 
    50                  55                  60                  


Ile His His Leu Glu Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val 
65                  70                  75                  80  


Phe Ala Gln Asn Glu Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile 
                85                  90                  95      


Met Leu Asn Leu Met His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp 
            100                 105                 110         


Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser Leu Thr Val 
        115                 120                 125             


Arg Ala Asp Ile Ala Gly Arg Tyr Ser Asn Arg Leu Tyr Thr Tyr Glu 
    130                 135                 140                 


Pro Arg Asp Leu Pro Leu Leu Ile Glu Asn Met Lys Lys Ala Leu Arg 
145                 150                 155                 160 


Leu Ile Gln Ser Glu Leu 
                165     


<210>  353
<211>  1471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGRN__Homo_sapiens__XP_011539733

<400>  353

Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His Val Ala 
1               5                   10                  15      


Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala Phe Gly 
            20                  25                  30          


Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu His Pro 
        35                  40                  45              


Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
    50                  55                  60                  


Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile Glu Glu 
65                  70                  75                  80  


Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly Gly Ser 
                85                  90                  95      


Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg Gln Arg 
            100                 105                 110         


Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val Cys Asp 
        115                 120                 125             


Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser Asp Gly 
    130                 135                 140                 


Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys Glu Ser 
145                 150                 155                 160 


Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly Pro Thr 
                165                 170                 175     


Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln Thr Pro 
            180                 185                 190         


Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val Gly Leu 
        195                 200                 205             


Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser Tyr Gly 
    210                 215                 220                 


Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro Gly Val 
225                 230                 235                 240 


Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn Phe Arg 
                245                 250                 255     


Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser Cys Asp 
            260                 265                 270         


Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly Leu Cys 
        275                 280                 285             


Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys Pro Asp 
    290                 295                 300                 


Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser Ala Pro 
305                 310                 315                 320 


Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys Val Glu 
                325                 330                 335     


Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys Pro Glu 
            340                 345                 350         


Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Asn 
        355                 360                 365             


Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln Ile Ser 
    370                 375                 380                 


Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser Thr His 
385                 390                 395                 400 


Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu Leu Ser 
                405                 410                 415     


Gln Ala Leu Pro Ala Pro Pro Gly Ala Leu Pro Leu Ala Pro Ser Ser 
            420                 425                 430         


Thr Ala His Ser Gln Thr Thr Pro Pro Pro Ser Ser Arg Pro Arg Thr 
        435                 440                 445             


Thr Ala Ser Val Pro Arg Thr Thr Val Trp Pro Val Leu Thr Val Pro 
    450                 455                 460                 


Pro Thr Ala Pro Ser Pro Ala Pro Ser Leu Val Ala Ser Ala Phe Gly 
465                 470                 475                 480 


Glu Ser Gly Ser Thr Asp Gly Ser Ser Asp Glu Glu Leu Ser Gly Asp 
                485                 490                 495     


Gln Glu Ala Ser Gly Gly Gly Ser Gly Gly Leu Glu Pro Leu Glu Gly 
            500                 505                 510         


Ser Ser Val Ala Thr Pro Gly Pro Pro Val Glu Arg Ala Ser Cys Tyr 
        515                 520                 525             


Asn Ser Ala Leu Gly Cys Cys Ser Asp Gly Lys Thr Pro Ser Leu Asp 
    530                 535                 540                 


Ala Glu Gly Ser Asn Cys Pro Ala Thr Lys Val Phe Gln Gly Val Leu 
545                 550                 555                 560 


Glu Leu Glu Gly Val Glu Gly Gln Glu Leu Phe Tyr Thr Pro Glu Met 
                565                 570                 575     


Ala Asp Pro Lys Ser Glu Leu Phe Gly Glu Thr Ala Arg Ser Ile Glu 
            580                 585                 590         


Ser Thr Leu Asp Asp Leu Phe Arg Asn Ser Asp Val Lys Lys Asp Phe 
        595                 600                 605             


Arg Ser Val Arg Leu Arg Asp Leu Gly Pro Gly Lys Ser Val Arg Ala 
    610                 615                 620                 


Ile Val Asp Val His Phe Asp Pro Thr Thr Ala Phe Arg Ala Pro Asp 
625                 630                 635                 640 


Val Ala Arg Ala Leu Leu Arg Gln Ile Gln Val Ser Arg Arg Arg Ser 
                645                 650                 655     


Leu Gly Val Arg Arg Pro Leu Gln Glu His Val Arg Phe Met Asp Phe 
            660                 665                 670         


Asp Trp Phe Pro Ala Phe Ile Thr Gly Ala Thr Ser Gly Ala Ile Ala 
        675                 680                 685             


Ala Gly Ala Thr Ala Arg Ala Thr Thr Ala Ser Arg Leu Pro Ser Ser 
    690                 695                 700                 


Ala Val Thr Pro Arg Ala Pro His Pro Ser His Thr Ser Gln Pro Val 
705                 710                 715                 720 


Ala Lys Thr Thr Ala Ala Pro Thr Thr Arg Arg Pro Pro Thr Thr Ala 
                725                 730                 735     


Pro Ser Arg Val Pro Gly Arg Arg Pro Pro Ala Pro Gln Gln Pro Pro 
            740                 745                 750         


Lys Pro Cys Asp Ser Gln Pro Cys Phe His Gly Gly Thr Cys Gln Asp 
        755                 760                 765             


Trp Ala Leu Gly Gly Gly Phe Thr Cys Ser Cys Pro Ala Gly Arg Gly 
    770                 775                 780                 


Gly Ala Val Cys Glu Lys Val Leu Gly Ala Pro Val Pro Ala Phe Glu 
785                 790                 795                 800 


Gly Arg Ser Phe Leu Ala Phe Pro Thr Leu Arg Ala Tyr His Thr Leu 
                805                 810                 815     


Arg Leu Ala Leu Glu Phe Arg Ala Leu Glu Pro Gln Gly Leu Leu Leu 
            820                 825                 830         


Tyr Asn Gly Asn Ala Arg Gly Lys Asp Phe Leu Ala Leu Ala Leu Leu 
        835                 840                 845             


Asp Gly Arg Val Gln Leu Arg Phe Asp Thr Gly Ser Gly Pro Ala Val 
    850                 855                 860                 


Leu Thr Ser Ala Val Pro Val Glu Pro Gly Gln Trp His Arg Leu Glu 
865                 870                 875                 880 


Leu Ser Arg His Trp Arg Arg Gly Thr Leu Ser Val Asp Gly Glu Thr 
                885                 890                 895     


Pro Val Leu Gly Glu Ser Pro Ser Gly Thr Asp Gly Leu Asn Leu Asp 
            900                 905                 910         


Thr Asp Leu Phe Val Gly Gly Val Pro Glu Asp Gln Ala Ala Val Ala 
        915                 920                 925             


Leu Glu Arg Thr Phe Val Gly Ala Gly Leu Arg Gly Cys Ile Arg Leu 
    930                 935                 940                 


Leu Asp Val Asn Asn Gln Arg Leu Glu Leu Gly Ile Gly Pro Gly Ala 
945                 950                 955                 960 


Ala Thr Arg Gly Ser Gly Val Gly Glu Cys Gly Asp His Pro Cys Leu 
                965                 970                 975     


Pro Asn Pro Cys His Gly Gly Ala Pro Cys Gln Asn Leu Glu Ala Gly 
            980                 985                 990         


Arg Phe His Cys Gln Cys Pro Pro  Gly Arg Val Gly Pro  Thr Cys Ala 
        995                 1000                 1005             


Asp Glu  Lys Ser Pro Cys Gln  Pro Asn Pro Cys His  Gly Ala Ala 
    1010                 1015                 1020             


Pro Cys  Arg Val Leu Pro Glu  Gly Gly Ala Gln Cys  Glu Cys Pro 
    1025                 1030                 1035             


Leu Gly  Arg Glu Gly Thr Phe  Cys Gln Thr Ala Ser  Gly Gln Asp 
    1040                 1045                 1050             


Gly Ser  Gly Pro Phe Leu Ala  Asp Phe Asn Gly Phe  Ser His Leu 
    1055                 1060                 1065             


Glu Leu  Arg Gly Leu His Thr  Phe Ala Arg Asp Leu  Gly Glu Lys 
    1070                 1075                 1080             


Met Ala  Leu Glu Val Val Phe  Leu Ala Arg Gly Pro  Ser Gly Leu 
    1085                 1090                 1095             


Leu Leu  Tyr Asn Gly Gln Lys  Thr Asp Gly Lys Gly  Asp Phe Val 
    1100                 1105                 1110             


Ser Leu  Ala Leu Arg Asp Arg  Arg Leu Glu Phe Arg  Tyr Asp Leu 
    1115                 1120                 1125             


Gly Lys  Gly Ala Ala Val Ile  Arg Ser Arg Glu Pro  Val Thr Leu 
    1130                 1135                 1140             


Gly Ala  Trp Thr Arg Val Ser  Leu Glu Arg Asn Gly  Arg Lys Gly 
    1145                 1150                 1155             


Ala Leu  Arg Val Gly Asp Gly  Pro Arg Val Leu Gly  Glu Ser Pro 
    1160                 1165                 1170             


Lys Ser  Arg Lys Val Pro His  Thr Val Leu Asn Leu  Lys Glu Pro 
    1175                 1180                 1185             


Leu Tyr  Val Gly Gly Ala Pro  Asp Phe Ser Lys Leu  Ala Arg Ala 
    1190                 1195                 1200             


Ala Ala  Val Ser Ser Gly Phe  Asp Gly Ala Ile Gln  Leu Val Ser 
    1205                 1210                 1215             


Leu Gly  Gly Arg Gln Leu Leu  Thr Pro Glu His Val  Leu Arg Gln 
    1220                 1225                 1230             


Val Asp  Val Thr Ser Phe Ala  Gly His Pro Cys Thr  Arg Ala Ser 
    1235                 1240                 1245             


Gly His  Pro Cys Leu Asn Gly  Ala Ser Cys Val Pro  Arg Glu Ala 
    1250                 1255                 1260             


Ala Tyr  Val Cys Leu Cys Pro  Gly Gly Phe Ser Gly  Pro His Cys 
    1265                 1270                 1275             


Glu Lys  Gly Leu Val Glu Lys  Ser Ala Gly Asp Val  Asp Thr Leu 
    1280                 1285                 1290             


Ala Phe  Asp Gly Arg Thr Phe  Val Glu Tyr Leu Asn  Ala Val Thr 
    1295                 1300                 1305             


Glu Ser  Glu Lys Ala Leu Gln  Ser Asn His Phe Glu  Leu Ser Leu 
    1310                 1315                 1320             


Arg Thr  Glu Ala Thr Gln Gly  Leu Val Leu Trp Ser  Gly Lys Ala 
    1325                 1330                 1335             


Thr Glu  Arg Ala Asp Tyr Val  Ala Leu Ala Ile Val  Asp Gly His 
    1340                 1345                 1350             


Leu Gln  Leu Ser Tyr Asn Leu  Gly Ser Gln Pro Val  Val Leu Arg 
    1355                 1360                 1365             


Ser Thr  Val Pro Val Asn Thr  Asn Arg Trp Leu Arg  Val Val Ala 
    1370                 1375                 1380             


His Arg  Glu Gln Arg Glu Gly  Ser Leu Gln Val Gly  Asn Glu Ala 
    1385                 1390                 1395             


Pro Val  Thr Gly Ser Ser Pro  Leu Gly Ala Thr Gln  Leu Asp Thr 
    1400                 1405                 1410             


Asp Gly  Ala Leu Trp Leu Gly  Gly Leu Pro Glu Leu  Pro Val Gly 
    1415                 1420                 1425             


Pro Ala  Leu Pro Lys Ala Tyr  Gly Thr Gly Phe Val  Gly Cys Leu 
    1430                 1435                 1440             


Arg Asp  Val Val Val Gly Arg  His Pro Leu His Leu  Leu Glu Asp 
    1445                 1450                 1455             


Ala Val  Thr Lys Pro Glu Leu  Arg Pro Cys Pro Thr  Pro 
    1460                 1465                 1470     


<210>  354
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGRP__Homo_sapiens__XP_011521229

<400>  354

Met Leu Thr Ala Ala Val Leu Ser Cys Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Ala Thr Arg Gly Ala Gln Met Gly Leu Ala Pro Met Glu Gly Ile Arg 
            20                  25                  30          


Arg Pro Asp Gln Ala Leu Leu Pro Glu Leu Pro Gly Leu Gly Leu Arg 
        35                  40                  45              


Ala Pro Leu Lys Lys Thr Thr Ala Glu Gln Ala Glu Glu Asp Leu Leu 
    50                  55                  60                  


Gln Glu Ala Gln Ala Leu Ala Glu Val Leu Asp Leu Gln Asp Arg Glu 
65                  70                  75                  80  


Pro Arg Ser Ser Arg Arg Cys Val Arg Leu His Glu Ser Cys Leu Gly 
                85                  90                  95      


Gln Gln Val Pro Cys Cys Asp Pro Cys Ala Thr Cys Tyr Cys Arg Phe 
            100                 105                 110         


Phe Asn Ala Phe Cys Tyr Cys Arg Lys Leu Gly Thr Ala Met Asn Pro 
        115                 120                 125             


Cys Ser Arg Thr 
    130         


<210>  355
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGT__Homo_sapiens__NP_000020

<400>  355

Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser 
1               5                   10                  15      


Leu Arg Ala Thr Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala 
            20                  25                  30          


Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu 
        35                  40                  45              


Ser Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp 
    50                  55                  60                  


Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp 
65                  70                  75                  80  


Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp 
                85                  90                  95      


Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe 
            100                 105                 110         


Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val 
        115                 120                 125             


His Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala 
    130                 135                 140                 


Ser Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala 
145                 150                 155                 160 


Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp 
                165                 170                 175     


Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val 
            180                 185                 190         


Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val 
        195                 200                 205             


Val Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val 
    210                 215                 220                 


Gln Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp 
225                 230                 235                 240 


Phe Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln 
                245                 250                 255     


Ala Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val 
            260                 265                 270         


Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met 
        275                 280                 285             


Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn 
    290                 295                 300                 


Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln 
305                 310                 315                 320 


His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Pro Phe 
                325                 330                 335     


Thr Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp 
            340                 345                 350         


Leu Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp 
        355                 360                 365             


Met Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu 
    370                 375                 380                 


Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu 
385                 390                 395                 400 


Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn 
                405                 410                 415     


Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu 
            420                 425                 430         


Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys 
        435                 440                 445             


Pro Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val 
    450                 455                 460                 


Tyr Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn 
465                 470                 475                 480 


Pro Leu Ser Thr Ala 
                485 


<210>  356
<211>  1278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGTPBP1__Homo_sapiens__NP_001273644

<400>  356

Met Arg Thr Gly Ser Ala Ala Ser Ser Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ser Ala Ser Pro Ala Thr Gly Val Cys Met Lys Thr Pro 
            20                  25                  30          


Gly Gly Gly Arg Arg Gly Ile Arg Arg Asp Pro Gly Ala Glu Pro Gly 
        35                  40                  45              


Ala Ala Ala Leu Arg Gly Pro Arg Gln Arg Pro Ile Leu Ser Arg Leu 
    50                  55                  60                  


Thr Asn Asn Ser Arg Ile Val Gly Leu Leu Ala Gln Leu Glu Lys Ile 
65                  70                  75                  80  


Asn Ala Glu Pro Ser Glu Ser Asp Thr Ala Arg Tyr Val Thr Ser Lys 
                85                  90                  95      


Ile Leu His Leu Ala Gln Ser Gln Glu Lys Thr Arg Arg Glu Met Thr 
            100                 105                 110         


Ala Lys Gly Ser Thr Gly Met Glu Ile Leu Leu Ser Thr Leu Glu Asn 
        115                 120                 125             


Thr Lys Asp Leu Gln Thr Thr Leu Asn Ile Leu Ser Ile Leu Val Glu 
    130                 135                 140                 


Leu Val Ser Ala Gly Gly Gly Arg Arg Val Ser Phe Leu Val Thr Lys 
145                 150                 155                 160 


Gly Gly Ser Gln Ile Leu Leu Gln Leu Leu Met Asn Ala Ser Lys Glu 
                165                 170                 175     


Ser Pro Pro His Glu Asp Leu Met Val Gln Ile His Ser Ile Leu Ala 
            180                 185                 190         


Lys Ile Gly Pro Lys Asp Lys Lys Phe Gly Val Lys Ala Arg Ile Asn 
        195                 200                 205             


Gly Ala Leu Asn Ile Thr Leu Asn Leu Val Lys Gln Asn Leu Gln Asn 
    210                 215                 220                 


His Arg Leu Val Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr Ser Ala 
225                 230                 235                 240 


Asn Ser Val Asn Ser Val Ser Leu Gly Lys Asn Gly Val Val Glu Leu 
                245                 250                 255     


Met Phe Lys Ile Ile Gly Pro Phe Ser Lys Lys Asn Ser Ser Leu Ile 
            260                 265                 270         


Lys Val Ala Leu Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys Thr Asn 
        275                 280                 285             


Ala Arg Arg Ala Val Asp Arg Gly Tyr Val Gln Val Leu Leu Thr Ile 
    290                 295                 300                 


Tyr Val Asp Trp His Arg His Asp Asn Arg His Arg Asn Met Leu Ile 
305                 310                 315                 320 


Arg Lys Gly Ile Leu Gln Ser Leu Lys Ser Val Thr Asn Ile Lys Leu 
                325                 330                 335     


Gly Arg Lys Ala Phe Ile Asp Ala Asn Gly Met Lys Ile Leu Tyr Asn 
            340                 345                 350         


Thr Ser Gln Glu Cys Leu Ala Val Arg Thr Leu Asp Pro Leu Val Asn 
        355                 360                 365             


Thr Ser Ser Leu Ile Met Arg Lys Cys Phe Pro Lys Asn Arg Leu Pro 
    370                 375                 380                 


Leu Pro Thr Ile Lys Ser Ser Phe His Phe Gln Leu Pro Val Ile Pro 
385                 390                 395                 400 


Val Thr Gly Pro Val Ala Gln Leu Tyr Ser Leu Pro Pro Glu Val Asp 
                405                 410                 415     


Asp Val Val Asp Glu Ser Asp Asp Asn Asp Asp Ile Asp Val Glu Ala 
            420                 425                 430         


Glu Asn Glu Thr Glu Asn Glu Asp Asp Leu Asp Gln Asn Phe Lys Asn 
        435                 440                 445             


Asp Asp Ile Glu Thr Asp Ile Asn Lys Leu Lys Pro Gln Gln Glu Pro 
    450                 455                 460                 


Gly Arg Thr Ile Glu Asp Leu Lys Met Tyr Glu His Leu Phe Pro Glu 
465                 470                 475                 480 


Leu Val Asp Asp Phe Gln Asp Tyr Asp Leu Ile Ser Lys Glu Pro Lys 
                485                 490                 495     


Pro Phe Val Phe Glu Gly Lys Val Arg Gly Pro Ile Val Val Pro Thr 
            500                 505                 510         


Ala Gly Glu Glu Thr Ser Gly Asn Ser Gly Asn Leu Arg Lys Val Val 
        515                 520                 525             


Met Lys Glu Asn Ile Ser Ser Lys Gly Asp Glu Gly Glu Lys Lys Ser 
    530                 535                 540                 


Thr Phe Met Asp Leu Ala Lys Glu Asp Ile Lys Asp Asn Asp Arg Thr 
545                 550                 555                 560 


Leu Gln Gln Gln Pro Gly Asp Gln Asn Arg Thr Ile Ser Ser Val His 
                565                 570                 575     


Gly Leu Asn Asn Asp Ile Val Lys Ala Leu Asp Arg Ile Thr Leu Gln 
            580                 585                 590         


Asn Ile Pro Ser Gln Thr Ala Pro Gly Phe Thr Ala Glu Met Lys Lys 
        595                 600                 605             


Asp Cys Ser Leu Pro Leu Thr Val Leu Thr Cys Ala Lys Ala Cys Pro 
    610                 615                 620                 


His Met Ala Thr Cys Gly Asn Val Leu Phe Glu Gly Arg Thr Val Gln 
625                 630                 635                 640 


Leu Gly Lys Leu Cys Cys Thr Gly Val Glu Thr Glu Asp Asp Glu Asp 
                645                 650                 655     


Thr Glu Ser Asn Ser Ser Val Glu Gln Ala Ser Val Glu Val Pro Asp 
            660                 665                 670         


Gly Pro Thr Leu His Asp Pro Asp Leu Tyr Ile Glu Ile Val Lys Asn 
        675                 680                 685             


Thr Lys Ser Val Pro Glu Tyr Ser Glu Val Ala Tyr Pro Asp Tyr Phe 
    690                 695                 700                 


Gly His Ile Pro Pro Pro Phe Lys Glu Pro Ile Leu Glu Arg Pro Tyr 
705                 710                 715                 720 


Gly Val Gln Arg Thr Lys Ile Ala Gln Asp Ile Glu Arg Leu Ile His 
                725                 730                 735     


Gln Ser Asp Ile Ile Asp Arg Val Val Tyr Asp Leu Asp Asn Pro Asn 
            740                 745                 750         


Tyr Thr Ile Pro Glu Glu Gly Asp Ile Leu Lys Phe Asn Ser Lys Phe 
        755                 760                 765             


Glu Ser Gly Asn Leu Arg Lys Val Ile Gln Ile Arg Lys Asn Glu Tyr 
    770                 775                 780                 


Asp Leu Ile Leu Asn Ser Asp Ile Asn Ser Asn His Tyr His Gln Trp 
785                 790                 795                 800 


Phe Tyr Phe Glu Val Ser Gly Met Arg Pro Gly Val Ala Tyr Arg Phe 
                805                 810                 815     


Asn Ile Ile Asn Cys Glu Lys Ser Asn Ser Gln Phe Asn Tyr Gly Met 
            820                 825                 830         


Gln Pro Leu Met Tyr Ser Val Gln Glu Ala Leu Asn Ala Arg Pro Trp 
        835                 840                 845             


Trp Ile Arg Met Gly Thr Asp Ile Cys Tyr Tyr Lys Asn His Phe Ser 
    850                 855                 860                 


Arg Ser Ser Val Ala Ala Gly Gly Gln Lys Gly Lys Ser Tyr Tyr Thr 
865                 870                 875                 880 


Ile Thr Phe Thr Val Asn Phe Pro His Lys Asp Asp Val Cys Tyr Phe 
                885                 890                 895     


Ala Tyr His Tyr Pro Tyr Thr Tyr Ser Thr Leu Gln Met His Leu Gln 
            900                 905                 910         


Lys Leu Glu Ser Ala His Asn Pro Gln Gln Ile Tyr Phe Arg Lys Asp 
        915                 920                 925             


Val Leu Cys Glu Thr Leu Ser Gly Asn Ser Cys Pro Leu Val Thr Ile 
    930                 935                 940                 


Thr Ala Met Pro Glu Ser Asn Tyr Tyr Glu His Ile Cys His Phe Arg 
945                 950                 955                 960 


Asn Arg Pro Tyr Val Phe Leu Ser Ala Arg Val His Pro Gly Glu Thr 
                965                 970                 975     


Asn Ala Ser Trp Val Met Lys Gly Thr Leu Glu Tyr Leu Met Ser Asn 
            980                 985                 990         


Asn Pro Thr Ala Gln Ser Leu Arg  Glu Ser Tyr Ile Phe  Lys Ile Val 
        995                 1000                 1005             


Pro Met  Leu Asn Pro Asp Gly  Val Ile Asn Gly Asn  His Arg Cys 
    1010                 1015                 1020             


Ser Leu  Ser Gly Glu Asp Leu  Asn Arg Gln Trp Gln  Ser Pro Ser 
    1025                 1030                 1035             


Pro Asp  Leu His Pro Thr Ile  Tyr His Ala Lys Gly  Leu Leu Gln 
    1040                 1045                 1050             


Tyr Leu  Ala Ala Val Lys Arg  Leu Pro Leu Val Tyr  Cys Asp Tyr 
    1055                 1060                 1065             


His Gly  His Ser Arg Lys Lys  Asn Val Phe Met Tyr  Gly Cys Ser 
    1070                 1075                 1080             


Ile Lys  Glu Thr Val Trp His  Thr Asn Asp Asn Ala  Thr Ser Cys 
    1085                 1090                 1095             


Asp Val  Val Glu Asp Thr Gly  Tyr Arg Thr Leu Pro  Lys Ile Leu 
    1100                 1105                 1110             


Ser His  Ile Ala Pro Ala Phe  Cys Met Ser Ser Cys  Ser Phe Val 
    1115                 1120                 1125             


Val Glu  Lys Ser Lys Glu Ser  Thr Ala Arg Val Val  Val Trp Arg 
    1130                 1135                 1140             


Glu Ile  Gly Val Gln Arg Ser  Tyr Thr Met Glu Ser  Thr Leu Cys 
    1145                 1150                 1155             


Gly Cys  Asp Gln Gly Lys Tyr  Lys Gly Leu Gln Ile  Gly Thr Arg 
    1160                 1165                 1170             


Glu Leu  Glu Glu Met Gly Ala  Lys Phe Cys Val Gly  Leu Leu Arg 
    1175                 1180                 1185             


Leu Lys  Arg Leu Thr Ser Pro  Leu Glu Tyr Asn Leu  Pro Ser Ser 
    1190                 1195                 1200             


Leu Leu  Asp Phe Glu Asn Asp  Leu Ile Glu Ser Ser  Cys Lys Val 
    1205                 1210                 1215             


Thr Ser  Pro Thr Thr Tyr Val  Leu Asp Glu Asp Glu  Pro Arg Phe 
    1220                 1225                 1230             


Leu Glu  Glu Val Asp Tyr Ser  Ala Glu Ser Asn Asp  Glu Leu Asp 
    1235                 1240                 1245             


Ile Glu  Leu Ala Glu Asn Val  Gly Asp Tyr Glu Pro  Ser Ala Gln 
    1250                 1255                 1260             


Glu Glu  Val Leu Ser Asp Ser  Glu Leu Ser Arg Thr  Tyr Leu Pro 
    1265                 1270                 1275             


<210>  357
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGTR1__Homo_sapiens__NP_004826

<400>  357

Met Lys Lys Met Asn His Lys Ser Thr Asp Ser Pro Lys Ala Pro Gln 
1               5                   10                  15      


Leu Arg Gly Gly Val Phe Asp Ile Val Phe Ala Thr Asn Ser Thr Gln 
            20                  25                  30          


Val Ile Lys Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg 
        35                  40                  45              


Ile Gln Asp Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val 
    50                  55                  60                  


Met Ile Pro Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly 
65                  70                  75                  80  


Asn Ser Leu Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr 
                85                  90                  95      


Val Ala Ser Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe 
            100                 105                 110         


Leu Leu Thr Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg 
        115                 120                 125             


Trp Pro Phe Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser 
    130                 135                 140                 


Phe Asn Leu Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp 
145                 150                 155                 160 


Arg Tyr Leu Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr 
                165                 170                 175     


Met Leu Val Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly 
            180                 185                 190         


Leu Ala Ser Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu 
        195                 200                 205             


Asn Thr Asn Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser 
    210                 215                 220                 


Thr Leu Pro Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu 
225                 230                 235                 240 


Phe Pro Phe Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala 
                245                 250                 255     


Leu Lys Lys Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp 
            260                 265                 270         


Ile Phe Lys Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp 
        275                 280                 285             


Ile Pro His Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly 
    290                 295                 300                 


Ile Ile Arg Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro 
305                 310                 315                 320 


Ile Thr Ile Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe 
                325                 330                 335     


Tyr Gly Phe Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu 
            340                 345                 350         


Lys Tyr Ile Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys 
        355                 360                 365             


Met Ser Thr Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr 
    370                 375                 380                 


Lys Lys Pro Ala Pro Cys Phe Glu Val Glu 
385                 390                 


<210>  358
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGTR2__Homo_sapiens__XP_011535835

<400>  358

Met Lys Gly Asn Ser Thr Leu Ala Thr Thr Ser Lys Asn Ile Thr Ser 
1               5                   10                  15      


Gly Leu His Phe Gly Leu Val Asn Ile Ser Gly Asn Asn Glu Ser Thr 
            20                  25                  30          


Leu Asn Cys Ser Gln Lys Pro Ser Asp Lys His Leu Asp Ala Ile Pro 
        35                  40                  45              


Ile Leu Tyr Tyr Ile Ile Phe Val Ile Gly Phe Leu Val Asn Ile Val 
    50                  55                  60                  


Val Val Thr Leu Phe Cys Cys Gln Lys Gly Pro Lys Lys Val Ser Ser 
65                  70                  75                  80  


Ile Tyr Ile Phe Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Ala Thr 
                85                  90                  95      


Leu Pro Leu Trp Ala Thr Tyr Tyr Ser Tyr Arg Tyr Asp Trp Leu Phe 
            100                 105                 110         


Gly Pro Val Met Cys Lys Val Phe Gly Ser Phe Leu Thr Leu Asn Met 
        115                 120                 125             


Phe Ala Ser Ile Phe Phe Ile Thr Cys Met Ser Val Asp Arg Tyr Gln 
    130                 135                 140                 


Ser Val Ile Tyr Pro Phe Leu Ser Gln Arg Arg Asn Pro Trp Gln Ala 
145                 150                 155                 160 


Ser Tyr Ile Val Pro Leu Val Trp Cys Met Ala Cys Leu Ser Ser Leu 
                165                 170                 175     


Pro Thr Phe Tyr Phe Arg Asp Val Arg Thr Ile Glu Tyr Leu Gly Val 
            180                 185                 190         


Asn Ala Cys Ile Met Ala Phe Pro Pro Glu Lys Tyr Ala Gln Trp Ser 
        195                 200                 205             


Ala Gly Ile Ala Leu Met Lys Asn Ile Leu Gly Phe Ile Ile Pro Leu 
    210                 215                 220                 


Ile Phe Ile Ala Thr Cys Tyr Phe Gly Ile Arg Lys His Leu Leu Lys 
225                 230                 235                 240 


Thr Asn Ser Tyr Gly Lys Asn Arg Ile Thr Arg Asp Gln Val Leu Lys 
                245                 250                 255     


Met Ala Ala Ala Val Val Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe 
            260                 265                 270         


His Val Leu Thr Phe Leu Asp Ala Leu Ala Trp Met Gly Val Ile Asn 
        275                 280                 285             


Ser Cys Glu Val Ile Ala Val Ile Asp Leu Ala Leu Pro Phe Ala Ile 
    290                 295                 300                 


Leu Leu Gly Phe Thr Asn Ser Cys Val Asn Pro Phe Leu Tyr Cys Phe 
305                 310                 315                 320 


Val Gly Asn Arg Phe Gln Gln Lys Leu Arg Ser Val Phe Arg Val Pro 
                325                 330                 335     


Ile Thr Trp Leu Gln Gly Lys Arg Glu Ser Met Ser Cys Arg Lys Ser 
            340                 345                 350         


Ser Ser Leu Arg Glu Met Glu Thr Phe Val Ser 
        355                 360             


<210>  359
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGXT2__Homo_sapiens__NP_114106

<400>  359

Met Thr Leu Ile Trp Arg His Leu Leu Arg Pro Leu Cys Leu Val Thr 
1               5                   10                  15      


Ser Ala Pro Arg Ile Leu Glu Met His Pro Phe Leu Ser Leu Gly Thr 
            20                  25                  30          


Ser Arg Thr Ser Val Thr Lys Leu Ser Leu His Thr Lys Pro Arg Met 
        35                  40                  45              


Pro Pro Cys Asp Phe Met Pro Glu Arg Tyr Gln Ser Leu Gly Tyr Asn 
    50                  55                  60                  


Arg Val Leu Glu Ile His Lys Glu His Leu Ser Pro Val Val Thr Ala 
65                  70                  75                  80  


Tyr Phe Gln Lys Pro Leu Leu Leu His Gln Gly His Met Glu Trp Leu 
                85                  90                  95      


Phe Asp Ala Glu Gly Ser Arg Tyr Leu Asp Phe Phe Ser Gly Ile Val 
            100                 105                 110         


Thr Val Ser Val Gly His Cys His Pro Lys Val Asn Ala Val Ala Gln 
        115                 120                 125             


Lys Gln Leu Gly Arg Leu Trp His Thr Ser Thr Val Phe Phe His Pro 
    130                 135                 140                 


Pro Met His Glu Tyr Ala Glu Lys Leu Ala Ala Leu Leu Pro Glu Pro 
145                 150                 155                 160 


Leu Lys Val Ile Phe Leu Val Asn Ser Gly Ser Glu Ala Asn Glu Leu 
                165                 170                 175     


Ala Met Leu Met Ala Arg Ala His Ser Asn Asn Ile Asp Ile Ile Ser 
            180                 185                 190         


Phe Arg Gly Ala Tyr His Gly Cys Ser Pro Tyr Thr Leu Gly Leu Thr 
        195                 200                 205             


Asn Val Gly Thr Tyr Lys Met Glu Leu Pro Gly Gly Thr Gly Cys Gln 
    210                 215                 220                 


Pro Thr Met Cys Pro Asp Val Phe Arg Gly Pro Trp Gly Gly Ser His 
225                 230                 235                 240 


Cys Arg Asp Ser Pro Val Gln Thr Ile Arg Lys Cys Ser Cys Ala Pro 
                245                 250                 255     


Asp Cys Cys Gln Ala Lys Asp Gln Tyr Ile Glu Gln Phe Lys Asp Thr 
            260                 265                 270         


Leu Ser Thr Ser Val Ala Lys Ser Ile Ala Gly Phe Phe Ala Glu Pro 
        275                 280                 285             


Ile Gln Gly Val Asn Gly Val Val Gln Tyr Pro Lys Gly Phe Leu Lys 
    290                 295                 300                 


Glu Ala Phe Glu Leu Val Arg Ala Arg Gly Gly Val Cys Ile Ala Asp 
305                 310                 315                 320 


Glu Val Gln Thr Gly Phe Gly Arg Leu Gly Ser His Phe Trp Gly Phe 
                325                 330                 335     


Gln Thr His Asp Val Leu Pro Asp Ile Val Thr Met Ala Lys Gly Ile 
            340                 345                 350         


Gly Asn Gly Phe Pro Met Ala Ala Val Ile Thr Thr Pro Glu Ile Ala 
        355                 360                 365             


Lys Ser Leu Ala Lys Cys Leu Gln His Phe Asn Thr Phe Gly Gly Asn 
    370                 375                 380                 


Pro Met Ala Cys Ala Ile Gly Ser Ala Val Leu Glu Val Ile Lys Glu 
385                 390                 395                 400 


Glu Asn Leu Gln Glu Asn Ser Gln Glu Val Gly Thr Tyr Met Leu Leu 
                405                 410                 415     


Lys Phe Ala Lys Leu Arg Asp Glu Phe Glu Ile Val Gly Asp Val Arg 
            420                 425                 430         


Gly Lys Gly Leu Met Ile Gly Ile Glu Met Val Gln Asp Lys Ile Ser 
        435                 440                 445             


Cys Arg Pro Leu Pro Arg Glu Glu Val Asn Gln Ile His Glu Asp Cys 
    450                 455                 460                 


Lys His Met Gly Leu Leu Val Gly Arg Gly Ser Ile Phe Ser Gln Thr 
465                 470                 475                 480 


Phe Arg Ile Ala Pro Ser Met Cys Ile Thr Lys Pro Glu Val Asp Phe 
                485                 490                 495     


Ala Val Glu Val Phe Arg Ser Ala Leu Thr Gln His Met Glu Arg Arg 
            500                 505                 510         


Ala Lys 
        


<210>  360
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGXT__Homo_sapiens__NP_000021

<400>  360

Met Ala Ser His Lys Leu Leu Val Thr Pro Pro Lys Ala Leu Leu Lys 
1               5                   10                  15      


Pro Leu Ser Ile Pro Asn Gln Leu Leu Leu Gly Pro Gly Pro Ser Asn 
            20                  25                  30          


Leu Pro Pro Arg Ile Met Ala Ala Gly Gly Leu Gln Met Ile Gly Ser 
        35                  40                  45              


Met Ser Lys Asp Met Tyr Gln Ile Met Asp Glu Ile Lys Glu Gly Ile 
    50                  55                  60                  


Gln Tyr Val Phe Gln Thr Arg Asn Pro Leu Thr Leu Val Ile Ser Gly 
65                  70                  75                  80  


Ser Gly His Cys Ala Leu Glu Ala Ala Leu Val Asn Val Leu Glu Pro 
                85                  90                  95      


Gly Asp Ser Phe Leu Val Gly Ala Asn Gly Ile Trp Gly Gln Arg Ala 
            100                 105                 110         


Val Asp Ile Gly Glu Arg Ile Gly Ala Arg Val His Pro Met Thr Lys 
        115                 120                 125             


Asp Pro Gly Gly His Tyr Thr Leu Gln Glu Val Glu Glu Gly Leu Ala 
    130                 135                 140                 


Gln His Lys Pro Val Leu Leu Phe Leu Thr His Gly Glu Ser Ser Thr 
145                 150                 155                 160 


Gly Val Leu Gln Pro Leu Asp Gly Phe Gly Glu Leu Cys His Arg Tyr 
                165                 170                 175     


Lys Cys Leu Leu Leu Val Asp Ser Val Ala Ser Leu Gly Gly Thr Pro 
            180                 185                 190         


Leu Tyr Met Asp Arg Gln Gly Ile Asp Ile Leu Tyr Ser Gly Ser Gln 
        195                 200                 205             


Lys Ala Leu Asn Ala Pro Pro Gly Thr Ser Leu Ile Ser Phe Ser Asp 
    210                 215                 220                 


Lys Ala Lys Lys Lys Met Tyr Ser Arg Lys Thr Lys Pro Phe Ser Phe 
225                 230                 235                 240 


Tyr Leu Asp Ile Lys Trp Leu Ala Asn Phe Trp Gly Cys Asp Asp Gln 
                245                 250                 255     


Pro Arg Met Tyr His His Thr Ile Pro Val Ile Ser Leu Tyr Ser Leu 
            260                 265                 270         


Arg Glu Ser Leu Ala Leu Ile Ala Glu Gln Gly Leu Glu Asn Ser Trp 
        275                 280                 285             


Arg Gln His Arg Glu Ala Ala Ala Tyr Leu His Gly Arg Leu Gln Ala 
    290                 295                 300                 


Leu Gly Leu Gln Leu Phe Val Lys Asp Pro Ala Leu Arg Leu Pro Thr 
305                 310                 315                 320 


Val Thr Thr Val Ala Val Pro Ala Gly Tyr Asp Trp Arg Asp Ile Val 
                325                 330                 335     


Ser Tyr Val Ile Asp His Phe Asp Ile Glu Ile Met Gly Gly Leu Gly 
            340                 345                 350         


Pro Ser Thr Gly Lys Val Leu Arg Ile Gly Leu Leu Gly Cys Asn Ala 
        355                 360                 365             


Thr Arg Glu Asn Val Asp Arg Val Thr Glu Ala Leu Arg Ala Ala Leu 
    370                 375                 380                 


Gln His Cys Pro Lys Lys Lys Leu 
385                 390         


<210>  361
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHCY__Homo_sapiens__NP_000678

<400>  361

Met Ser Asp Lys Leu Pro Tyr Lys Val Ala Asp Ile Gly Leu Ala Ala 
1               5                   10                  15      


Trp Gly Arg Lys Ala Leu Asp Ile Ala Glu Asn Glu Met Pro Gly Leu 
            20                  25                  30          


Met Arg Met Arg Glu Arg Tyr Ser Ala Ser Lys Pro Leu Lys Gly Ala 
        35                  40                  45              


Arg Ile Ala Gly Cys Leu His Met Thr Val Glu Thr Ala Val Leu Ile 
    50                  55                  60                  


Glu Thr Leu Val Thr Leu Gly Ala Glu Val Gln Trp Ser Ser Cys Asn 
65                  70                  75                  80  


Ile Phe Ser Thr Gln Asp His Ala Ala Ala Ala Ile Ala Lys Ala Gly 
                85                  90                  95      


Ile Pro Val Tyr Ala Trp Lys Gly Glu Thr Asp Glu Glu Tyr Leu Trp 
            100                 105                 110         


Cys Ile Glu Gln Thr Leu Tyr Phe Lys Asp Gly Pro Leu Asn Met Ile 
        115                 120                 125             


Leu Asp Asp Gly Gly Asp Leu Thr Asn Leu Ile His Thr Lys Tyr Pro 
    130                 135                 140                 


Gln Leu Leu Pro Gly Ile Arg Gly Ile Ser Glu Glu Thr Thr Thr Gly 
145                 150                 155                 160 


Val His Asn Leu Tyr Lys Met Met Ala Asn Gly Ile Leu Lys Val Pro 
                165                 170                 175     


Ala Ile Asn Val Asn Asp Ser Val Thr Lys Ser Lys Phe Asp Asn Leu 
            180                 185                 190         


Tyr Gly Cys Arg Glu Ser Leu Ile Asp Gly Ile Lys Arg Ala Thr Asp 
        195                 200                 205             


Val Met Ile Ala Gly Lys Val Ala Val Val Ala Gly Tyr Gly Asp Val 
    210                 215                 220                 


Gly Lys Gly Cys Ala Gln Ala Leu Arg Gly Phe Gly Ala Arg Val Ile 
225                 230                 235                 240 


Ile Thr Glu Ile Asp Pro Ile Asn Ala Leu Gln Ala Ala Met Glu Gly 
                245                 250                 255     


Tyr Glu Val Thr Thr Met Asp Glu Ala Cys Gln Glu Gly Asn Ile Phe 
            260                 265                 270         


Val Thr Thr Thr Gly Cys Ile Asp Ile Ile Leu Gly Arg His Phe Glu 
        275                 280                 285             


Gln Met Lys Asp Asp Ala Ile Val Cys Asn Ile Gly His Phe Asp Val 
    290                 295                 300                 


Glu Ile Asp Val Lys Trp Leu Asn Glu Asn Ala Val Glu Lys Val Asn 
305                 310                 315                 320 


Ile Lys Pro Gln Val Asp Arg Tyr Arg Leu Lys Asn Gly Arg Arg Ile 
                325                 330                 335     


Ile Leu Leu Ala Glu Gly Arg Leu Val Asn Leu Gly Cys Ala Met Gly 
            340                 345                 350         


His Pro Ser Phe Val Met Ser Asn Ser Phe Thr Asn Gln Val Met Ala 
        355                 360                 365             


Gln Ile Glu Leu Trp Thr His Pro Asp Lys Tyr Pro Val Gly Val His 
    370                 375                 380                 


Phe Leu Pro Lys Lys Leu Asp Glu Ala Val Ala Glu Ala His Leu Gly 
385                 390                 395                 400 


Lys Leu Asn Val Lys Leu Thr Lys Leu Thr Glu Lys Gln Ala Gln Tyr 
                405                 410                 415     


Leu Gly Met Ser Cys Asp Gly Pro Phe Lys Pro Asp His Tyr Arg Tyr 
            420                 425                 430         


<210>  362
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHCYL2__Homo_sapiens__NP_001124192

<400>  362

Met Ser Val Gln Val Val Ser Ala Ala Ala Ala Ala Lys Val Pro Glu 
1               5                   10                  15      


Val Glu Leu Lys Asp Leu Ser Pro Ser Glu Ala Glu Ser Gln Leu Gly 
            20                  25                  30          


Leu Ser Thr Ala Ala Val Gly Ala Met Ala Pro Pro Ala Gly Gly Gly 
        35                  40                  45              


Asp Pro Glu Ala Pro Ala Pro Ala Ala Glu Arg Pro Pro Val Pro Gly 
    50                  55                  60                  


Pro Gly Ser Gly Pro Ala Ala Ala Leu Ser Pro Ala Ala Gly Lys Val 
65                  70                  75                  80  


Pro Gln Ala Ser Ala Met Lys Arg Ser Asp Pro His His Gln His Gln 
                85                  90                  95      


Arg His Arg Asp Gly Gly Glu Ala Leu Val Ser Pro Asp Gly Thr Val 
            100                 105                 110         


Thr Glu Ala Pro Arg Thr Val Lys Lys Ile Gln Phe Ala Asp Gln Lys 
        115                 120                 125             


Gln Glu Phe Asn Lys Arg Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser 
    130                 135                 140                 


Arg Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser 
145                 150                 155                 160 


Tyr Thr Asp Ser Ser Asp Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln 
                165                 170                 175     


Lys Asn Ser Lys Gly Ser Ser Asp Phe Cys Val Lys Asn Ile Lys Gln 
            180                 185                 190         


Ala Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Glu Met Pro 
        195                 200                 205             


Ala Leu Met Ala Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala 
    210                 215                 220                 


Gly Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala Gln Thr Ala Val 
225                 230                 235                 240 


Leu Met Glu Thr Leu Gly Ala Leu Gly Ala Gln Cys Arg Trp Ala Ala 
                245                 250                 255     


Cys Asn Ile Tyr Ser Thr Leu Asn Glu Val Ala Ala Ala Leu Ala Glu 
            260                 265                 270         


Ser Gly Phe Pro Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe 
        275                 280                 285             


Trp Trp Cys Ile Asp Arg Cys Val Asn Val Glu Gly Trp Gln Pro Asn 
    290                 295                 300                 


Met Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp Ile Tyr Lys Lys 
305                 310                 315                 320 


Tyr Pro Asn Met Phe Lys Lys Ile Lys Gly Ile Val Glu Glu Ser Val 
                325                 330                 335     


Thr Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys 
            340                 345                 350         


Val Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe Asp 
        355                 360                 365             


Asn Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr 
    370                 375                 380                 


Thr Asp Met Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr Gly 
385                 390                 395                 400 


Glu Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Met Gly Ser Ile 
                405                 410                 415     


Val Tyr Val Thr Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys Met 
            420                 425                 430         


Asp Gly Phe Arg Leu Val Lys Leu Asn Glu Val Ile Arg Gln Val Asp 
        435                 440                 445             


Ile Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val Thr Arg Glu His 
    450                 455                 460                 


Leu Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His Ser 
465                 470                 475                 480 


Asn Thr Glu Ile Asp Val Ala Ser Leu Arg Thr Pro Glu Leu Thr Trp 
                485                 490                 495     


Glu Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly Lys 
            500                 505                 510         


Arg Ile Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser 
        515                 520                 525             


Thr Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu 
    530                 535                 540                 


Ala Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp 
545                 550                 555                 560 


Val Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu His 
                565                 570                 575     


Leu Pro Thr Phe Asp Ala His Leu Thr Glu Leu Thr Asp Glu Gln Ala 
            580                 585                 590         


Lys Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr 
        595                 600                 605             


Arg Tyr 
    610 


<210>  363
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHI1__Homo_sapiens__NP_001128304

<400>  363

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30          


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr 
        35                  40                  45              


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro 
    50                  55                  60                  


Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp 
65                  70                  75                  80  


Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val 
                85                  90                  95      


Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn 
            100                 105                 110         


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125             


Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu 
    130                 135                 140                 


Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys 
145                 150                 155                 160 


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175     


Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190         


Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205             


Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu 
    210                 215                 220                 


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240 


Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly 
                245                 250                 255     


Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270         


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285             


Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr 
    290                 295                 300                 


Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320 


Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335     


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr 
            340                 345                 350         


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365             


His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380                 


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400 


Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415     


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430         


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445             


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460                 


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480 


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495     


Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510         


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525             


Thr Leu Tyr Val Thr Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540                 


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560 


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro 
                565                 570                 575     


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590         


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605             


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620                 


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640 


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655     


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser 
            660                 665                 670         


Ser Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr 
        675                 680                 685             


Asn Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys 
    690                 695                 700                 


Phe His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser 
705                 710                 715                 720 


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735     


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750         


Asp Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile 
        755                 760                 765             


Val Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780                 


His His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly 
785                 790                 795                 800 


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815     


Ile His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830         


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845             


Ser Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860                 


Gly Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met 
865                 870                 875                 880 


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895     


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910         


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925             


Met Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940                 


Ser Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960 


Phe Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met 
                965                 970                 975     


Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser 
            980                 985                 990         


Cys Ala Ala Lys Val Asn Lys Asn  Leu Ser Phe Thr Ser  Pro Pro Ala 
        995                 1000                 1005             


Val Ser  Ser Gln Gln Ser Lys  Leu Lys Gln Ser Asn  Met Leu Thr 
    1010                 1015                 1020             


Ala Gln  Glu Ile Leu His Gln  Phe Gly Phe Thr Gln  Thr Asp Ser 
    1025                 1030                 1035             


His Phe  Ala Glu Phe Asn Thr  Cys Ile Leu Trp Trp  Lys Lys His 
    1040                 1045                 1050             


<210>  364
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHNAK__Homo_sapiens__NP_076965

<400>  364

Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Asn Thr Pro Gln Pro Ser Ala Leu Glu Cys Lys Asp Gln Asn 
        115                 120                 125             


Lys Gln Lys Glu Ala Ser Ser Gln Ala Gly Ala Val Ser Val Ser Thr 
    130                 135                 140                 


Pro Asn Ala Gly Leu 
145                 


<210>  365
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHR__Homo_sapiens__NP_001612

<400>  365

Met Asn Ser Ser Ser Ala Asn Ile Thr Tyr Ala Ser Arg Lys Arg Arg 
1               5                   10                  15      


Lys Pro Val Gln Lys Thr Val Lys Pro Ile Pro Ala Glu Gly Ile Lys 
            20                  25                  30          


Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Thr Glu Leu Asp 
        35                  40                  45              


Arg Leu Ala Ser Leu Leu Pro Phe Pro Gln Asp Val Ile Asn Lys Leu 
    50                  55                  60                  


Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Ala Lys 
65                  70                  75                  80  


Ser Phe Phe Asp Val Ala Leu Lys Ser Ser Pro Thr Glu Arg Asn Gly 
                85                  90                  95      


Gly Gln Asp Asn Cys Arg Ala Ala Asn Phe Arg Glu Gly Leu Asn Leu 
            100                 105                 110         


Gln Glu Gly Glu Phe Leu Leu Gln Ala Leu Asn Gly Phe Val Leu Val 
        115                 120                 125             


Val Thr Thr Asp Ala Leu Val Phe Tyr Ala Ser Ser Thr Ile Gln Asp 
    130                 135                 140                 


Tyr Leu Gly Phe Gln Gln Ser Asp Val Ile His Gln Ser Val Tyr Glu 
145                 150                 155                 160 


Leu Ile His Thr Glu Asp Arg Ala Glu Phe Gln Arg Gln Leu His Trp 
                165                 170                 175     


Ala Leu Asn Pro Ser Gln Cys Thr Glu Ser Gly Gln Gly Ile Glu Glu 
            180                 185                 190         


Ala Thr Gly Leu Pro Gln Thr Val Val Cys Tyr Asn Pro Asp Gln Ile 
        195                 200                 205             


Pro Pro Glu Asn Ser Pro Leu Met Glu Arg Cys Phe Ile Cys Arg Leu 
    210                 215                 220                 


Arg Cys Leu Leu Asp Asn Ser Ser Gly Phe Leu Ala Met Asn Phe Gln 
225                 230                 235                 240 


Gly Lys Leu Lys Tyr Leu His Gly Gln Lys Lys Lys Gly Lys Asp Gly 
                245                 250                 255     


Ser Ile Leu Pro Pro Gln Leu Ala Leu Phe Ala Ile Ala Thr Pro Leu 
            260                 265                 270         


Gln Pro Pro Ser Ile Leu Glu Ile Arg Thr Lys Asn Phe Ile Phe Arg 
        275                 280                 285             


Thr Lys His Lys Leu Asp Phe Thr Pro Ile Gly Cys Asp Ala Lys Gly 
    290                 295                 300                 


Arg Ile Val Leu Gly Tyr Thr Glu Ala Glu Leu Cys Thr Arg Gly Ser 
305                 310                 315                 320 


Gly Tyr Gln Phe Ile His Ala Ala Asp Met Leu Tyr Cys Ala Glu Ser 
                325                 330                 335     


His Ile Arg Met Ile Lys Thr Gly Glu Ser Gly Met Ile Val Phe Arg 
            340                 345                 350         


Leu Leu Thr Lys Asn Asn Arg Trp Thr Trp Val Gln Ser Asn Ala Arg 
        355                 360                 365             


Leu Leu Tyr Lys Asn Gly Arg Pro Asp Tyr Ile Ile Val Thr Gln Arg 
    370                 375                 380                 


Pro Leu Thr Asp Glu Glu Gly Thr Glu His Leu Arg Lys Arg Asn Thr 
385                 390                 395                 400 


Lys Leu Pro Phe Met Phe Thr Thr Gly Glu Ala Val Leu Tyr Glu Ala 
                405                 410                 415     


Thr Asn Pro Phe Pro Ala Ile Met Asp Pro Leu Pro Leu Arg Thr Lys 
            420                 425                 430         


Asn Gly Thr Ser Gly Lys Asp Ser Ala Thr Thr Ser Thr Leu Ser Lys 
        435                 440                 445             


Asp Ser Leu Asn Pro Ser Ser Leu Leu Ala Ala Met Met Gln Gln Asp 
    450                 455                 460                 


Glu Ser Ile Tyr Leu Tyr Pro Ala Ser Ser Thr Ser Ser Thr Ala Pro 
465                 470                 475                 480 


Phe Glu Asn Asn Phe Phe Asn Glu Ser Met Asn Glu Cys Arg Asn Trp 
                485                 490                 495     


Gln Asp Asn Thr Ala Pro Met Gly Asn Asp Thr Ile Leu Lys His Glu 
            500                 505                 510         


Gln Ile Asp Gln Pro Gln Asp Val Asn Ser Phe Ala Gly Gly His Pro 
        515                 520                 525             


Gly Leu Phe Gln Asp Ser Lys Asn Ser Asp Leu Tyr Ser Ile Met Lys 
    530                 535                 540                 


Asn Leu Gly Ile Asp Phe Glu Asp Ile Arg His Met Gln Asn Glu Lys 
545                 550                 555                 560 


Phe Phe Arg Asn Asp Phe Ser Gly Glu Val Asp Phe Arg Asp Ile Asp 
                565                 570                 575     


Leu Thr Asp Glu Ile Leu Thr Tyr Val Gln Asp Ser Leu Ser Lys Ser 
            580                 585                 590         


Pro Phe Ile Pro Ser Asp Tyr Gln Gln Gln Gln Ser Leu Ala Leu Asn 
        595                 600                 605             


Ser Ser Cys Met Val Gln Glu His Leu His Leu Glu Gln Gln Gln Gln 
    610                 615                 620                 


His His Gln Lys Gln Val Val Val Glu Pro Gln Gln Gln Leu Cys Gln 
625                 630                 635                 640 


Lys Met Lys His Met Gln Val Asn Gly Met Phe Glu Asn Trp Asn Ser 
                645                 650                 655     


Asn Gln Phe Val Pro Phe Asn Cys Pro Gln Gln Asp Pro Gln Gln Tyr 
            660                 665                 670         


Asn Val Phe Thr Asp Leu His Gly Ile Ser Gln Glu Phe Pro Tyr Lys 
        675                 680                 685             


Ser Glu Met Asp Ser Met Pro Tyr Thr Gln Asn Phe Ile Ser Cys Asn 
    690                 695                 700                 


Gln Pro Val Leu Pro Gln His Ser Lys Cys Thr Glu Leu Asp Tyr Pro 
705                 710                 715                 720 


Met Gly Ser Phe Glu Pro Ser Pro Tyr Pro Thr Thr Ser Ser Leu Glu 
                725                 730                 735     


Asp Phe Val Thr Cys Leu Gln Leu Pro Glu Asn Gln Lys His Gly Leu 
            740                 745                 750         


Asn Pro Gln Ser Ala Ile Ile Thr Pro Gln Thr Cys Tyr Ala Gly Ala 
        755                 760                 765             


Val Ser Met Tyr Gln Cys Gln Pro Glu Pro Gln His Thr His Val Gly 
    770                 775                 780                 


Gln Met Gln Tyr Asn Pro Val Leu Pro Gly Gln Gln Ala Phe Leu Asn 
785                 790                 795                 800 


Lys Phe Gln Asn Gly Val Leu Asn Glu Thr Tyr Pro Ala Glu Leu Asn 
                805                 810                 815     


Asn Ile Asn Asn Thr Gln Thr Thr Thr His Leu Gln Pro Leu His His 
            820                 825                 830         


Pro Ser Glu Ala Arg Pro Phe Pro Asp Leu Thr Ser Ser Gly Phe Leu 
        835                 840                 845             


<210>  366
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHRR__Homo_sapiens__NP_001229341

<400>  366

Met Pro Arg Thr Met Ile Pro Pro Gly Glu Cys Thr Tyr Ala Gly Arg 
1               5                   10                  15      


Lys Arg Arg Arg Pro Leu Gln Lys Gln Arg Pro Ala Val Gly Ala Glu 
            20                  25                  30          


Lys Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Ala Glu Leu 
        35                  40                  45              


Asp His Leu Ala Ser Leu Leu Pro Phe Pro Pro Asp Ile Ile Ser Lys 
    50                  55                  60                  


Leu Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Val 
65                  70                  75                  80  


Lys Ser Phe Phe Gln Val Val Gln Glu Gln Ser Ser Arg Gln Pro Ala 
                85                  90                  95      


Ala Gly Ala Pro Ser Pro Gly Asp Ser Cys Pro Leu Ala Gly Ser Ala 
            100                 105                 110         


Val Leu Glu Gly Arg Leu Leu Leu Glu Ser Leu Asn Gly Phe Ala Leu 
        115                 120                 125             


Val Val Ser Ala Glu Gly Thr Ile Phe Tyr Ala Ser Ala Thr Ile Val 
    130                 135                 140                 


Asp Tyr Leu Gly Phe His Gln Thr Asp Val Met His Gln Asn Ile Tyr 
145                 150                 155                 160 


Asp Tyr Ile His Val Asp Asp Arg Gln Asp Phe Cys Arg Gln Leu His 
                165                 170                 175     


Trp Ala Met Asp Pro Pro Gln Val Val Phe Gly Gln Pro Pro Pro Leu 
            180                 185                 190         


Glu Thr Gly Asp Asp Ala Ile Leu Gly Arg Leu Leu Arg Ala Gln Glu 
        195                 200                 205             


Trp Gly Thr Gly Thr Pro Thr Glu Tyr Ser Ala Phe Leu Thr Arg Cys 
    210                 215                 220                 


Phe Ile Cys Arg Val Arg Cys Leu Leu Asp Ser Thr Ser Gly Phe Leu 
225                 230                 235                 240 


Thr Met Gln Phe Gln Gly Lys Leu Lys Phe Leu Phe Gly Gln Lys Lys 
                245                 250                 255     


Lys Ala Pro Ser Gly Ala Met Leu Pro Pro Arg Leu Ser Leu Phe Cys 
            260                 265                 270         


Ile Ala Ala Pro Val Leu Leu Pro Ser Ala Ala Glu Met Lys Met Arg 
        275                 280                 285             


Ser Ala Leu Leu Arg Ala Lys Pro Arg Ala Asp Thr Ala Ala Thr Ala 
    290                 295                 300                 


Asp Ala Lys Val Lys Ala Thr Thr Ser Leu Cys Glu Ser Glu Leu His 
305                 310                 315                 320 


Gly Lys Pro Asn Tyr Ser Ala Gly Arg Ser Ser Arg Glu Ser Gly Val 
                325                 330                 335     


Leu Val Leu Arg Glu Gln Thr Asp Ala Gly Arg Trp Ala Gln Val Pro 
            340                 345                 350         


Ala Arg Ala Pro Cys Leu Cys Leu Arg Gly Gly Pro Asp Leu Val Leu 
        355                 360                 365             


Asp Pro Lys Gly Gly Ser Gly Asp Arg Glu Glu Glu Gln His Arg Met 
    370                 375                 380                 


Leu Ser Arg Ala Ser Gly Val Thr Gly Arg Arg Glu Thr Pro Gly Pro 
385                 390                 395                 400 


Thr Lys Pro Leu Pro Trp Thr Ala Gly Lys His Ser Glu Asp Gly Ala 
                405                 410                 415     


Arg Pro Arg Leu Gln Pro Ser Lys Asn Asp Pro Pro Ser Leu Arg Pro 
            420                 425                 430         


Met Pro Arg Gly Ser Cys Leu Pro Cys Pro Cys Val Gln Gly Thr Phe 
        435                 440                 445             


Arg Asn Ser Pro Ile Ser His Pro Pro Ser Pro Ser Pro Ser Ala Tyr 
    450                 455                 460                 


Ser Ser Arg Thr Ser Arg Pro Met Arg Asp Val Gly Glu Asp Gln Val 
465                 470                 475                 480 


His Pro Pro Leu Cys His Phe Pro Gln Arg Ser Leu Gln His Gln Leu 
                485                 490                 495     


Pro Gln Pro Gly Ala Gln Arg Phe Ala Thr Arg Gly Tyr Pro Met Glu 
            500                 505                 510         


Asp Met Lys Leu Gln Gly Val Pro Met Pro Pro Gly Asp Leu Cys Gly 
        515                 520                 525             


Pro Thr Leu Leu Leu Asp Val Ser Ile Lys Met Glu Lys Asp Ser Gly 
    530                 535                 540                 


Cys Glu Gly Ala Ala Asp Gly Cys Val Pro Ser Gln Val Trp Leu Gly 
545                 550                 555                 560 


Ala Ser Asp Arg Ser His Pro Ala Thr Phe Pro Thr Arg Met His Leu 
                565                 570                 575     


Lys Thr Glu Pro Asp Ser Arg Gln Gln Val Tyr Ile Ser His Leu Gly 
            580                 585                 590         


His Gly Val Arg Gly Ala Gln Pro His Gly Arg Ala Thr Ala Gly Arg 
        595                 600                 605             


Ser Arg Glu Leu Thr Pro Phe His Pro Ala His Cys Ala Cys Leu Glu 
    610                 615                 620                 


Pro Thr Asp Gly Leu Pro Gln Ser Glu Pro Pro His Gln Leu Cys Ala 
625                 630                 635                 640 


Arg Gly Arg Gly Glu Gln Ser Cys Thr Cys Arg Ala Ala Glu Ala Ala 
                645                 650                 655     


Pro Val Val Lys Arg Glu Pro Leu Asp Ser Pro Gln Trp Ala Thr His 
            660                 665                 670         


Ser Gln Gly Met Val Pro Gly Met Leu Pro Lys Ser Ala Leu Ala Thr 
        675                 680                 685             


Leu Val Pro Pro Gln Ala Ser Gly Cys Thr Phe Leu Pro 
    690                 695                 700     


<210>  367
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHSA1__Homo_sapiens__NP_036243

<400>  367

Met Ala Lys Trp Gly Glu Gly Asp Pro Arg Trp Ile Val Glu Glu Arg 
1               5                   10                  15      


Ala Asp Ala Thr Asn Val Asn Asn Trp His Trp Thr Glu Arg Asp Ala 
            20                  25                  30          


Ser Asn Trp Ser Thr Asp Lys Leu Lys Thr Leu Phe Leu Ala Val Gln 
        35                  40                  45              


Val Gln Asn Glu Glu Gly Lys Cys Glu Val Thr Glu Val Ser Lys Leu 
    50                  55                  60                  


Asp Gly Glu Ala Ser Ile Asn Asn Arg Lys Gly Lys Leu Ile Phe Phe 
65                  70                  75                  80  


Tyr Glu Trp Ser Val Lys Leu Asn Trp Thr Gly Thr Ser Lys Ser Gly 
                85                  90                  95      


Val Gln Tyr Lys Gly His Val Glu Ile Pro Asn Leu Ser Asp Glu Asn 
            100                 105                 110         


Ser Val Asp Glu Val Glu Ile Ser Val Ser Leu Ala Lys Asp Glu Pro 
        115                 120                 125             


Asp Thr Asn Leu Val Ala Leu Met Lys Glu Glu Gly Val Lys Leu Leu 
    130                 135                 140                 


Arg Glu Ala Met Gly Ile Tyr Ile Ser Thr Leu Lys Thr Glu Phe Thr 
145                 150                 155                 160 


Gln Gly Met Ile Leu Pro Thr Met Asn Gly Glu Ser Val Asp Pro Val 
                165                 170                 175     


Gly Gln Pro Ala Leu Lys Thr Glu Glu Arg Lys Ala Lys Pro Ala Pro 
            180                 185                 190         


Ser Lys Thr Gln Ala Arg Pro Val Gly Val Lys Ile Pro Thr Cys Lys 
        195                 200                 205             


Ile Thr Leu Lys Glu Thr Phe Leu Thr Ser Pro Glu Glu Leu Tyr Arg 
    210                 215                 220                 


Val Phe Thr Thr Gln Glu Leu Val Gln Ala Phe Thr His Ala Pro Ala 
225                 230                 235                 240 


Thr Leu Glu Ala Asp Arg Gly Gly Lys Phe His Met Val Asp Gly Asn 
                245                 250                 255     


Val Ser Gly Glu Phe Thr Asp Leu Val Pro Glu Lys His Ile Val Met 
            260                 265                 270         


Lys Trp Arg Phe Lys Ser Trp Pro Glu Gly His Phe Ala Thr Ile Thr 
        275                 280                 285             


Leu Thr Phe Ile Asp Lys Asn Gly Glu Thr Glu Leu Cys Met Glu Gly 
    290                 295                 300                 


Arg Gly Ile Pro Ala Pro Glu Glu Glu Arg Thr Arg Gln Gly Trp Gln 
305                 310                 315                 320 


Arg Tyr Tyr Phe Glu Gly Ile Lys Gln Thr Phe Gly Tyr Gly Ala Arg 
                325                 330                 335     


Leu Phe 
        


<210>  368
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHSA2__Homo_sapiens__NP_689605

<400>  368

Met Ile Leu Pro Thr Lys Ala Met Ala Thr Gln Glu Leu Thr Val Lys 
1               5                   10                  15      


Arg Lys Leu Ser Gly Asn Thr Leu Gln Val Gln Ala Ser Ser Pro Val 
            20                  25                  30          


Ala Leu Gly Val Arg Ile Pro Thr Val Ala Leu His Met Met Glu Leu 
        35                  40                  45              


Phe Asp Thr Thr Val Glu Gln Leu Tyr Ser Ile Phe Thr Val Lys Glu 
    50                  55                  60                  


Leu Thr Asn Lys Lys Ile Ile Met Lys Trp Arg Cys Gly Asn Trp Pro 
65                  70                  75                  80  


Glu Glu His Tyr Ala Met Val Ala Leu Asn Phe Val Pro Thr Leu Gly 
                85                  90                  95      


Gln Thr Glu Leu Gln Leu Lys Glu Phe Leu Ser Ile Cys Lys Glu Glu 
            100                 105                 110         


Asn Met Lys Phe Cys Trp Gln Lys Gln His Phe Glu Glu Ile Lys Gly 
        115                 120                 125             


Ser Leu Gln Leu Thr Pro Leu Asn Gly 
    130                 135         


<210>  369
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AHSG__Homo_sapiens__NP_001613

<400>  369

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser Ala Pro His Gly Pro Gly Leu Ile Tyr Arg Gln Pro Asn Cys 
            20                  25                  30          


Asp Asp Pro Glu Thr Glu Glu Ala Ala Leu Val Ala Ile Asp Tyr Ile 
        35                  40                  45              


Asn Gln Asn Leu Pro Trp Gly Tyr Lys His Thr Leu Asn Gln Ile Asp 
    50                  55                  60                  


Glu Val Lys Val Trp Pro Gln Gln Pro Ser Gly Glu Leu Phe Glu Ile 
65                  70                  75                  80  


Glu Ile Asp Thr Leu Glu Thr Thr Cys His Val Leu Asp Pro Thr Pro 
                85                  90                  95      


Val Ala Arg Cys Ser Val Arg Gln Leu Lys Glu His Ala Val Glu Gly 
            100                 105                 110         


Asp Cys Asp Phe Gln Leu Leu Lys Leu Asp Gly Lys Phe Ser Val Val 
        115                 120                 125             


Tyr Ala Lys Cys Asp Ser Ser Pro Asp Ser Ala Glu Asp Val Arg Lys 
    130                 135                 140                 


Val Cys Gln Asp Cys Pro Leu Leu Ala Pro Leu Asn Asp Thr Arg Val 
145                 150                 155                 160 


Val His Ala Ala Lys Ala Ala Leu Ala Ala Phe Asn Ala Gln Asn Asn 
                165                 170                 175     


Gly Ser Asn Phe Gln Leu Glu Glu Ile Ser Arg Ala Gln Leu Val Pro 
            180                 185                 190         


Leu Pro Pro Ser Thr Tyr Val Glu Phe Thr Val Ser Gly Thr Asp Cys 
        195                 200                 205             


Val Ala Lys Glu Ala Thr Glu Ala Ala Lys Cys Asn Leu Leu Ala Glu 
    210                 215                 220                 


Lys Gln Tyr Gly Phe Cys Lys Ala Thr Leu Ser Glu Lys Leu Gly Gly 
225                 230                 235                 240 


Ala Glu Val Ala Val Thr Cys Met Val Phe Gln Thr Gln Pro Val Ser 
                245                 250                 255     


Ser Gln Pro Gln Pro Glu Gly Ala Asn Glu Ala Val Pro Thr Pro Val 
            260                 265                 270         


Val Asp Pro Asp Ala Pro Pro Ser Pro Pro Leu Gly Ala Pro Gly Leu 
        275                 280                 285             


Pro Pro Ala Gly Ser Pro Pro Asp Ser His Val Leu Leu Ala Ala Pro 
    290                 295                 300                 


Pro Gly His Gln Leu His Arg Ala His Tyr Asp Leu Arg His Thr Phe 
305                 310                 315                 320 


Met Gly Val Val Ser Leu Gly Ser Pro Ser Gly Glu Val Ser His Pro 
                325                 330                 335     


Arg Lys Thr Arg Thr Val Val Gln Pro Ser Val Gly Ala Ala Ala Gly 
            340                 345                 350         


Pro Val Val Pro Pro Cys Pro Gly Arg Ile Arg His Phe Lys Val 
        355                 360                 365         


<210>  370
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AICDA__Homo_sapiens__NP_065712

<400>  370

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys Tyr Val 
            20                  25                  30          


Val Lys Arg Arg Asp Ser Ala Thr Ser Phe Ser Leu Asp Phe Gly Tyr 
        35                  40                  45              


Leu Arg Asn Lys Asn Gly Cys His Val Glu Leu Leu Phe Leu Arg Tyr 
    50                  55                  60                  


Ile Ser Asp Trp Asp Leu Asp Pro Gly Arg Cys Tyr Arg Val Thr Trp 
65                  70                  75                  80  


Phe Thr Ser Trp Ser Pro Cys Tyr Asp Cys Ala Arg His Val Ala Asp 
                85                  90                  95      


Phe Leu Arg Gly Asn Pro Asn Leu Ser Leu Arg Ile Phe Thr Ala Arg 
            100                 105                 110         


Leu Tyr Phe Cys Glu Asp Arg Lys Ala Glu Pro Glu Gly Leu Arg Arg 
        115                 120                 125             


Leu His Arg Ala Gly Val Gln Ile Ala Ile Met Thr Phe Lys Asp Tyr 
    130                 135                 140                 


Phe Tyr Cys Trp Asn Thr Phe Val Glu Asn His Glu Arg Thr Phe Lys 
145                 150                 155                 160 


Ala Trp Glu Gly Leu His Glu Asn Ser Val Arg Leu Ser Arg Gln Leu 
                165                 170                 175     


Arg Arg Ile Leu Leu Pro Leu Tyr Glu Val Asp Asp Leu Arg Asp Ala 
            180                 185                 190         


Phe Arg Thr Leu Gly Leu 
        195             


<210>  371
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIDA__Homo_sapiens__NP_073742

<400>  371

Met Ser Glu Val Thr Arg Ser Leu Leu Gln Arg Trp Gly Ala Ser Phe 
1               5                   10                  15      


Arg Arg Gly Ala Asp Phe Asp Ser Trp Gly Gln Leu Val Glu Ala Ile 
            20                  25                  30          


Asp Glu Tyr Gln Ile Leu Ala Arg His Leu Gln Lys Glu Ala Gln Ala 
        35                  40                  45              


Gln His Asn Asn Ser Glu Phe Thr Glu Glu Gln Lys Lys Thr Ile Gly 
    50                  55                  60                  


Lys Ile Ala Thr Cys Leu Glu Leu Arg Ser Ala Ala Leu Gln Ser Thr 
65                  70                  75                  80  


Gln Ser Gln Glu Glu Phe Lys Leu Glu Asp Leu Lys Lys Leu Glu Pro 
                85                  90                  95      


Ile Leu Lys Asn Ile Leu Thr Tyr Asn Lys Glu Phe Pro Phe Asp Val 
            100                 105                 110         


Gln Pro Val Pro Leu Arg Arg Ile Leu Ala Pro Gly Glu Glu Glu Asn 
        115                 120                 125             


Leu Glu Phe Glu Glu Asp Glu Glu Glu Gly Gly Ala Gly Ala Gly Ser 
    130                 135                 140                 


Pro Asp Ser Phe Pro Ala Arg Val Pro Gly Thr Leu Leu Pro Arg Leu 
145                 150                 155                 160 


Pro Ser Glu Pro Gly Met Thr Leu Leu Thr Ile Arg Ile Glu Lys Ile 
                165                 170                 175     


Gly Leu Lys Asp Ala Gly Gln Cys Ile Asp Pro Tyr Ile Thr Val Ser 
            180                 185                 190         


Val Lys Asp Leu Asn Gly Ile Asp Leu Thr Pro Val Gln Asp Thr Pro 
        195                 200                 205             


Val Ala Ser Arg Lys Glu Asp Thr Tyr Val His Phe Asn Val Asp Ile 
    210                 215                 220                 


Glu Leu Gln Lys His Val Glu Lys Leu Thr Lys Gly Ala Ala Ile Phe 
225                 230                 235                 240 


Phe Glu Phe Lys His Tyr Lys Pro Lys Lys Arg Phe Thr Ser Thr Lys 
                245                 250                 255     


Cys Phe Ala Phe Met Glu Met Asp Glu Ile Lys Pro Gly Pro Ile Val 
            260                 265                 270         


Ile Glu Leu Tyr Lys Lys Pro Thr Asp Phe Lys Arg Lys Lys Leu Gln 
        275                 280                 285             


Leu Leu Thr Lys Lys Pro Leu Tyr Leu His Leu His Gln Thr Leu His 
    290                 295                 300                 


Lys Glu 
305     


<210>  372
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIF1__Homo_sapiens__NP_001614

<400>  372

Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210>  373
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIFM1__Homo_sapiens__NP_001124318

<400>  373

Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr Met Glu Lys 
1               5                   10                  15      


Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser 
            20                  25                  30          


Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg 
        35                  40                  45              


Lys Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn 
    50                  55                  60                  


Val Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly 
65                  70                  75                  80  


Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val 
                85                  90                  95      


Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg 
            100                 105                 110         


Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu 
        115                 120                 125             


Asn Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp 
    130                 135                 140                 


Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp 
145                 150                 155                 160 


Ser Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr Ala Gln Asp 
                165                 170                 175     


Asn Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile Arg Ser Glu 
            180                 185                 190         


Ser Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro Pro Ser Thr 
        195                 200                 205             


Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly 
    210                 215                 220                 


Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp 
225                 230                 235                 240 


Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly 
                245                 250                 255     


Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His 
            260                 265                 270         


Glu Asp 
        


<210>  374
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIFM2__Homo_sapiens__NP_001185625

<400>  374

Met Gly Ser Gln Val Ser Val Glu Ser Gly Ala Leu His Val Val Ile 
1               5                   10                  15      


Val Gly Gly Gly Phe Gly Gly Ile Ala Ala Ala Ser Gln Leu Gln Ala 
            20                  25                  30          


Leu Asn Val Pro Phe Met Leu Val Asp Met Lys Asp Ser Phe His His 
        35                  40                  45              


Asn Val Ala Ala Leu Arg Ala Ser Val Glu Thr Gly Phe Ala Lys Lys 
    50                  55                  60                  


Thr Phe Ile Ser Tyr Ser Val Thr Phe Lys Asp Asn Phe Arg Gln Gly 
65                  70                  75                  80  


Leu Val Val Gly Ile Asp Leu Lys Asn Gln Met Val Leu Leu Gln Gly 
                85                  90                  95      


Gly Glu Ala Leu Pro Phe Ser His Leu Ile Leu Ala Thr Gly Ser Thr 
            100                 105                 110         


Gly Pro Phe Pro Gly Lys Phe Asn Glu Val Ser Ser Gln Gln Ala Ala 
        115                 120                 125             


Ile Gln Ala Tyr Glu Asp Met Val Arg Gln Val Gln Arg Ser Arg Phe 
    130                 135                 140                 


Ile Val Val Val Gly Gly Gly Ser Ala Gly Val Glu Met Ala Ala Glu 
145                 150                 155                 160 


Ile Lys Thr Glu Tyr Pro Glu Lys Glu Val Thr Leu Ile His Ser Gln 
                165                 170                 175     


Val Ala Leu Ala Asp Lys Glu Leu Leu Pro Ser Val Arg Gln Glu Val 
            180                 185                 190         


Lys Glu Ile Leu Leu Arg Lys Gly Val Gln Leu Leu Leu Ser Glu Arg 
        195                 200                 205             


Val Ser Asn Leu Glu Glu Leu Pro Leu Asn Glu Tyr Arg Glu Tyr Ile 
    210                 215                 220                 


Lys Val Gln Thr Asp Lys Gly Thr Glu Val Ala Thr Asn Leu Val Ile 
225                 230                 235                 240 


Leu Cys Thr Gly Ile Lys Ile Asn Ser Ser Ala Tyr Arg Lys Ala Phe 
                245                 250                 255     


Glu Ser Arg Leu Ala Ser Ser Gly Ala Leu Arg Val Asn Glu His Leu 
            260                 265                 270         


Gln Val Glu Gly His Ser Asn Val Tyr Ala Ile Gly Asp Cys Ala Asp 
        275                 280                 285             


Val Arg Thr Pro Lys Met Ala Tyr Leu Ala Gly Leu His Ala Asn Ile 
    290                 295                 300                 


Ala Val Ala Asn Ile Val Asn Ser Val Lys Gln Arg Pro Leu Gln Ala 
305                 310                 315                 320 


Tyr Lys Pro Gly Ala Leu Thr Phe Leu Leu Ser Met Gly Arg Asn Asp 
                325                 330                 335     


Gly Val Gly Gln Ile Ser Gly Phe Tyr Val Gly Arg Leu Met Val Arg 
            340                 345                 350         


Leu Thr Lys Ser Arg Asp Leu Phe Val Ser Thr Ser Trp Lys Thr Met 
        355                 360                 365             


Arg Gln Ser Pro Pro 
    370             


<210>  375
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIFM3__Homo_sapiens__NP_001018070

<400>  375

Met Gly Gly Cys Phe Ser Lys Pro Lys Pro Val Glu Leu Lys Ile Glu 
1               5                   10                  15      


Val Val Leu Pro Glu Lys Glu Arg Gly Lys Glu Glu Leu Ser Ala Ser 
            20                  25                  30          


Gly Lys Gly Ser Pro Arg Ala Tyr Gln Gly Asn Gly Thr Ala Arg His 
        35                  40                  45              


Phe His Thr Glu Glu Arg Leu Ser Thr Pro His Pro Tyr Pro Ser Pro 
    50                  55                  60                  


Gln Asp Cys Val Glu Ala Ala Val Cys His Val Lys Asp Leu Glu Asn 
65                  70                  75                  80  


Gly Gln Met Arg Glu Val Glu Leu Gly Trp Gly Lys Val Leu Leu Val 
                85                  90                  95      


Lys Asp Asn Gly Glu Phe His Ala Leu Gly His Lys Cys Pro His Tyr 
            100                 105                 110         


Gly Ala Pro Leu Val Lys Gly Val Leu Ser Arg Gly Arg Val Arg Cys 
        115                 120                 125             


Pro Trp His Gly Ala Cys Phe Asn Ile Ser Thr Gly Asp Leu Glu Asp 
    130                 135                 140                 


Phe Pro Gly Leu Asp Ser Leu His Lys Phe Gln Val Lys Ile Glu Lys 
145                 150                 155                 160 


Glu Lys Val Tyr Val Arg Ala Ser Lys Gln Ala Leu Gln Leu Gln Arg 
                165                 170                 175     


Arg Thr Lys Val Met Ala Lys Cys Ile Ser Pro Ser Ala Gly Tyr Ser 
            180                 185                 190         


Ser Ser Thr Asn Val Leu Ile Val Gly Ala Gly Ala Ala Gly Leu Val 
        195                 200                 205             


Cys Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu 
    210                 215                 220                 


Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys 
225                 230                 235                 240 


Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe 
                245                 250                 255     


Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr 
            260                 265                 270         


Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu 
        275                 280                 285             


Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu 
    290                 295                 300                 


Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro 
305                 310                 315                 320 


Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val 
                325                 330                 335     


Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr 
            340                 345                 350         


Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe 
        355                 360                 365             


Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe 
    370                 375                 380                 


Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu 
385                 390                 395                 400 


Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys 
                405                 410                 415     


Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala 
            420                 425                 430         


Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe 
        435                 440                 445             


Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala 
    450                 455                 460                 


Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys 
465                 470                 475                 480 


Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala 
                485                 490                 495     


Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr 
            500                 505                 510         


Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly 
        515                 520                 525             


Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys 
    530                 535                 540                 


Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser 
545                 550                 555                 560 


Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser 
                565                 570                 575     


Gly Arg Ala Ile Arg Lys Arg Glu Val Glu Thr Gly Asp Met Ser Trp 
            580                 585                 590         


Leu Thr Gly Lys Gly Ser 
        595             


<210>  376
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIG1__Homo_sapiens__NP_001273516

<400>  376

Met Ala Ile Leu Leu Ser Tyr Cys Ser Ile Leu Cys Asn Tyr Lys Ala 
1               5                   10                  15      


Ile Glu Met Pro Ser His Gln Thr Tyr Gly Gly Ser Trp Lys Phe Leu 
            20                  25                  30          


Thr Phe Ile Asp Leu Val Ile Gln Ala Val Phe Phe Gly Ile Cys Val 
        35                  40                  45              


Leu Thr Asp Leu Ser Ser Leu Leu Thr Arg Gly Ser Gly Asn Gln Glu 
    50                  55                  60                  


Gln Glu Arg Gln Leu Lys Lys Leu Ile Ser Leu Arg Asp Trp Met Leu 
65                  70                  75                  80  


Ala Val Leu Ala Phe Pro Val Gly Val Phe Val Val Ala Val Phe Trp 
                85                  90                  95      


Ile Ile Tyr Ala Tyr Asp Arg Glu Met Ile Tyr Pro Lys Leu Leu Asp 
            100                 105                 110         


Asn Phe Ile Pro Gly Trp Leu Asn His Gly Met His Thr Thr Val Leu 
        115                 120                 125             


Pro Phe Ile Leu Ile Glu Met Arg Thr Ser His His Gln Tyr Pro Ser 
    130                 135                 140                 


Arg Ser Ser Gly Leu Thr Ala Ile Cys Thr Phe Ser Val Gly Tyr Ile 
145                 150                 155                 160 


Leu Trp Val Cys Trp Val His His Val Thr Gly Met Trp Val Tyr Pro 
                165                 170                 175     


Phe Leu Glu His Ile Gly Pro Gly Ala Arg Ile Ile Phe Phe Gly Ser 
            180                 185                 190         


Thr Thr Ile Leu Met Asn Phe Leu Tyr Leu Leu Gly Glu Val Leu Asn 
        195                 200                 205             


Asn Tyr Ile Trp Asp Thr Gln Lys Ser Met Glu Glu Glu Lys Glu Lys 
    210                 215                 220                 


Pro Lys Leu Glu 
225             


<210>  377
<211>  1723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIM1__Homo_sapiens__NP_001615

<400>  377

Met Glu Lys Arg Ser Ser Gly Arg Arg Ser Gly Arg Arg Arg Gly Ser 
1               5                   10                  15      


Gln Lys Ser Thr Asp Ser Pro Gly Ala Asp Ala Glu Leu Pro Glu Ser 
            20                  25                  30          


Ala Ala Arg Asp Asp Ala Val Phe Asp Asp Glu Val Ala Pro Asn Ala 
        35                  40                  45              


Ala Ser Asp Asn Ala Ser Ala Glu Lys Lys Val Lys Ser Pro Arg Ala 
    50                  55                  60                  


Ala Leu Asp Gly Gly Val Ala Ser Ala Ala Ser Pro Glu Ser Lys Pro 
65                  70                  75                  80  


Ser Pro Gly Thr Lys Gly Gln Leu Arg Gly Glu Ser Asp Arg Ser Lys 
                85                  90                  95      


Gln Pro Pro Pro Ala Ser Ser Pro Thr Lys Arg Lys Gly Arg Ser Arg 
            100                 105                 110         


Ala Leu Glu Ala Val Pro Ala Pro Pro Ala Ser Gly Pro Arg Ala Pro 
        115                 120                 125             


Ala Lys Glu Ser Pro Pro Lys Arg Val Pro Asp Pro Ser Pro Val Thr 
    130                 135                 140                 


Lys Gly Thr Ala Ala Glu Ser Gly Glu Glu Ala Ala Arg Ala Ile Pro 
145                 150                 155                 160 


Arg Glu Leu Pro Val Lys Ser Ser Ser Leu Leu Pro Glu Ile Lys Pro 
                165                 170                 175     


Glu His Lys Arg Gly Pro Leu Pro Asn His Phe Asn Gly Arg Ala Glu 
            180                 185                 190         


Gly Gly Arg Ser Arg Glu Leu Gly Arg Ala Ala Gly Ala Pro Gly Ala 
        195                 200                 205             


Ser Asp Ala Asp Gly Leu Lys Pro Arg Asn His Phe Gly Val Gly Arg 
    210                 215                 220                 


Ser Thr Val Thr Thr Lys Val Thr Leu Pro Ala Lys Pro Lys His Val 
225                 230                 235                 240 


Glu Leu Asn Leu Lys Thr Pro Lys Asn Leu Asp Ser Leu Gly Asn Glu 
                245                 250                 255     


His Asn Pro Phe Ser Gln Pro Val His Lys Gly Asn Thr Ala Thr Lys 
            260                 265                 270         


Ile Ser Leu Phe Glu Asn Lys Arg Thr Asn Ser Ser Pro Arg His Thr 
        275                 280                 285             


Asp Ile Arg Gly Gln Arg Asn Thr Pro Ala Ser Ser Lys Thr Phe Val 
    290                 295                 300                 


Gly Arg Ala Lys Leu Asn Leu Ala Lys Lys Ala Lys Glu Met Glu Gln 
305                 310                 315                 320 


Pro Glu Lys Lys Val Met Pro Asn Ser Pro Gln Asn Gly Val Leu Val 
                325                 330                 335     


Lys Glu Thr Ala Ile Glu Thr Lys Val Thr Val Ser Glu Glu Glu Ile 
            340                 345                 350         


Leu Pro Ala Thr Arg Gly Met Asn Gly Asp Ser Ser Glu Asn Gln Ala 
        355                 360                 365             


Leu Gly Pro Gln Pro Asn Gln Asp Asp Lys Ala Asp Val Gln Thr Asp 
    370                 375                 380                 


Ala Gly Cys Leu Ser Glu Pro Val Ala Ser Ala Leu Ile Pro Val Lys 
385                 390                 395                 400 


Asp His Lys Leu Leu Glu Lys Glu Asp Ser Glu Ala Ala Asp Ser Lys 
                405                 410                 415     


Ser Leu Val Leu Glu Asn Val Thr Asp Thr Ala Gln Asp Ile Pro Thr 
            420                 425                 430         


Thr Val Asp Thr Lys Asp Leu Pro Pro Thr Ala Met Pro Lys Pro Gln 
        435                 440                 445             


His Thr Phe Ser Asp Ser Gln Ser Pro Ala Glu Ser Ser Pro Gly Pro 
    450                 455                 460                 


Ser Leu Ser Leu Ser Ala Pro Ala Pro Gly Asp Val Pro Lys Asp Thr 
465                 470                 475                 480 


Cys Val Gln Ser Pro Ile Ser Ser Phe Pro Cys Thr Asp Leu Lys Val 
                485                 490                 495     


Ser Glu Asn His Lys Gly Cys Val Leu Pro Val Ser Arg Gln Asn Asn 
            500                 505                 510         


Glu Lys Met Pro Leu Leu Glu Leu Gly Gly Glu Thr Thr Pro Pro Leu 
        515                 520                 525             


Ser Thr Glu Arg Ser Pro Glu Ala Val Gly Ser Glu Cys Pro Ser Arg 
    530                 535                 540                 


Val Leu Val Gln Val Arg Ser Phe Val Leu Pro Val Glu Ser Thr Gln 
545                 550                 555                 560 


Asp Val Ser Ser Gln Val Ile Pro Glu Ser Ser Glu Val Arg Glu Val 
                565                 570                 575     


Gln Leu Pro Thr Cys His Ser Asn Glu Pro Glu Val Val Ser Val Ala 
            580                 585                 590         


Ser Cys Ala Pro Pro Gln Glu Glu Val Leu Gly Asn Glu His Ser His 
        595                 600                 605             


Cys Thr Ala Glu Leu Ala Ala Lys Ser Gly Pro Gln Val Ile Pro Pro 
    610                 615                 620                 


Ala Ser Glu Lys Thr Leu Pro Ile Gln Ala Gln Ser Gln Gly Ser Arg 
625                 630                 635                 640 


Thr Pro Leu Met Ala Glu Ser Ser Pro Thr Asn Ser Pro Ser Ser Gly 
                645                 650                 655     


Asn His Leu Ala Thr Pro Gln Arg Pro Asp Gln Thr Val Thr Asn Gly 
            660                 665                 670         


Gln Asp Ser Pro Ala Ser Leu Leu Asn Ile Ser Ala Gly Ser Asp Asp 
        675                 680                 685             


Ser Val Phe Asp Ser Ser Ser Asp Met Glu Lys Phe Thr Glu Ile Ile 
    690                 695                 700                 


Lys Gln Met Asp Ser Ala Val Cys Met Pro Met Lys Arg Lys Lys Ala 
705                 710                 715                 720 


Arg Met Pro Asn Ser Pro Ala Pro His Phe Ala Met Pro Pro Ile His 
                725                 730                 735     


Glu Asp His Leu Glu Lys Val Phe Asp Pro Lys Val Phe Thr Phe Gly 
            740                 745                 750         


Leu Gly Lys Lys Lys Glu Ser Gln Pro Glu Met Ser Pro Ala Leu His 
        755                 760                 765             


Leu Met Gln Asn Leu Asp Thr Lys Ser Lys Leu Arg Pro Lys Arg Ala 
    770                 775                 780                 


Ser Ala Glu Gln Ser Val Leu Phe Lys Ser Leu His Thr Asn Thr Asn 
785                 790                 795                 800 


Gly Asn Ser Glu Pro Leu Val Met Pro Glu Ile Asn Asp Lys Glu Asn 
                805                 810                 815     


Arg Asp Val Thr Asn Gly Gly Ile Lys Arg Ser Arg Leu Glu Lys Ser 
            820                 825                 830         


Ala Leu Phe Ser Ser Leu Leu Ser Ser Leu Pro Gln Asp Lys Ile Phe 
        835                 840                 845             


Ser Pro Ser Val Thr Ser Val Asn Thr Met Thr Thr Ala Phe Ser Thr 
    850                 855                 860                 


Ser Gln Asn Gly Ser Leu Ser Gln Ser Ser Val Ser Gln Pro Thr Thr 
865                 870                 875                 880 


Glu Gly Ala Pro Pro Cys Gly Leu Asn Lys Glu Gln Ser Asn Leu Leu 
                885                 890                 895     


Pro Asp Asn Ser Leu Lys Val Phe Asn Phe Asn Ser Ser Ser Thr Ser 
            900                 905                 910         


His Ser Ser Leu Lys Ser Pro Ser His Met Glu Lys Tyr Pro Gln Lys 
        915                 920                 925             


Glu Lys Thr Lys Glu Asp Leu Asp Ser Arg Ser Asn Leu His Leu Pro 
    930                 935                 940                 


Glu Thr Lys Phe Ser Glu Leu Ser Lys Leu Lys Asn Asp Asp Met Glu 
945                 950                 955                 960 


Lys Ala Asn His Ile Glu Ser Val Ile Lys Ser Asn Leu Pro Asn Cys 
                965                 970                 975     


Ala Asn Ser Asp Thr Asp Phe Met Gly Leu Phe Lys Ser Ser Arg Tyr 
            980                 985                 990         


Asp Pro Ser Ile Ser Phe Ser Gly  Met Ser Leu Ser Asp  Thr Met Thr 
        995                 1000                 1005             


Leu Arg  Gly Ser Val Gln Asn  Lys Leu Asn Pro Arg  Pro Gly Lys 
    1010                 1015                 1020             


Val Val  Ile Tyr Ser Glu Pro  Asp Val Ser Glu Lys  Cys Ile Glu 
    1025                 1030                 1035             


Val Phe  Ser Asp Ile Gln Asp  Cys Ser Ser Trp Ser  Leu Ser Pro 
    1040                 1045                 1050             


Val Ile  Leu Ile Lys Val Val  Arg Gly Cys Trp Ile  Leu Tyr Glu 
    1055                 1060                 1065             


Gln Pro  Asn Phe Glu Gly His  Ser Ile Pro Leu Glu  Glu Gly Glu 
    1070                 1075                 1080             


Leu Glu  Leu Ser Gly Leu Trp  Gly Ile Glu Asp Ile  Leu Glu Arg 
    1085                 1090                 1095             


His Glu  Glu Ala Glu Ser Asp  Lys Pro Val Val Ile  Gly Ser Ile 
    1100                 1105                 1110             


Arg His  Val Val Gln Asp Tyr  Arg Val Ser His Ile  Asp Leu Phe 
    1115                 1120                 1125             


Thr Glu  Pro Glu Gly Leu Gly  Ile Leu Ser Ser Tyr  Phe Asp Asp 
    1130                 1135                 1140             


Thr Glu  Glu Met Gln Gly Phe  Gly Val Met Gln Lys  Thr Cys Ser 
    1145                 1150                 1155             


Met Lys  Val His Trp Gly Thr  Trp Leu Ile Tyr Glu  Glu Pro Gly 
    1160                 1165                 1170             


Phe Gln  Gly Val Pro Phe Ile  Leu Glu Pro Gly Glu  Tyr Pro Asp 
    1175                 1180                 1185             


Leu Ser  Phe Trp Asp Thr Glu  Glu Ala Tyr Ile Gly  Ser Met Arg 
    1190                 1195                 1200             


Pro Leu  Lys Met Gly Gly Arg  Lys Val Glu Phe Pro  Thr Asp Pro 
    1205                 1210                 1215             


Lys Val  Val Val Tyr Glu Lys  Pro Phe Phe Glu Gly  Lys Cys Val 
    1220                 1225                 1230             


Glu Leu  Glu Thr Gly Met Cys  Ser Phe Val Met Glu  Gly Gly Glu 
    1235                 1240                 1245             


Thr Glu  Glu Ala Thr Gly Asp  Asp His Leu Pro Phe  Thr Ser Val 
    1250                 1255                 1260             


Gly Ser  Met Lys Val Leu Arg  Gly Ile Trp Val Ala  Tyr Glu Lys 
    1265                 1270                 1275             


Pro Gly  Phe Thr Gly His Gln  Tyr Leu Leu Glu Glu  Gly Glu Tyr 
    1280                 1285                 1290             


Arg Asp  Trp Lys Ala Trp Gly  Gly Tyr Asn Gly Glu  Leu Gln Ser 
    1295                 1300                 1305             


Leu Arg  Pro Ile Leu Gly Asp  Phe Ser Asn Ala His  Met Ile Met 
    1310                 1315                 1320             


Tyr Ser  Glu Lys Asn Phe Gly  Ser Lys Gly Ser Ser  Ile Asp Val 
    1325                 1330                 1335             


Leu Gly  Ile Val Ala Asn Leu  Lys Glu Thr Gly Tyr  Gly Val Lys 
    1340                 1345                 1350             


Thr Gln  Ser Ile Asn Val Leu  Ser Gly Val Trp Val  Ala Tyr Glu 
    1355                 1360                 1365             


Asn Pro  Asp Phe Thr Gly Glu  Gln Tyr Ile Leu Asp  Lys Gly Phe 
    1370                 1375                 1380             


Tyr Thr  Ser Phe Glu Asp Trp  Gly Gly Lys Asn Cys  Lys Ile Ser 
    1385                 1390                 1395             


Ser Val  Gln Pro Ile Cys Leu  Asp Ser Phe Thr Gly  Pro Arg Arg 
    1400                 1405                 1410             


Arg Asn  Gln Ile His Leu Phe  Ser Glu Pro Gln Phe  Gln Gly His 
    1415                 1420                 1425             


Ser Gln  Ser Phe Glu Glu Thr  Thr Ser Gln Ile Asp  Asp Ser Phe 
    1430                 1435                 1440             


Ser Thr  Lys Ser Cys Arg Val  Ser Gly Gly Ser Trp  Val Val Tyr 
    1445                 1450                 1455             


Asp Gly  Glu Asn Phe Thr Gly  Asn Gln Tyr Val Leu  Glu Glu Gly 
    1460                 1465                 1470             


His Tyr  Pro Cys Leu Ser Ala  Met Gly Cys Pro Pro  Gly Ala Thr 
    1475                 1480                 1485             


Phe Lys  Ser Leu Arg Phe Ile  Asp Val Glu Phe Ser  Glu Pro Thr 
    1490                 1495                 1500             


Ile Ile  Leu Phe Glu Arg Glu  Asp Phe Lys Gly Lys  Lys Ile Glu 
    1505                 1510                 1515             


Leu Asn  Ala Glu Thr Val Asn  Leu Arg Ser Leu Gly  Phe Asn Thr 
    1520                 1525                 1530             


Gln Ile  Arg Ser Val Gln Val  Ile Gly Gly Ile Trp  Val Thr Tyr 
    1535                 1540                 1545             


Glu Tyr  Gly Ser Tyr Arg Gly  Arg Gln Phe Leu Leu  Ser Pro Ala 
    1550                 1555                 1560             


Glu Val  Pro Asn Trp Tyr Glu  Phe Ser Gly Cys Arg  Gln Ile Gly 
    1565                 1570                 1575             


Ser Leu  Arg Pro Phe Val Gln  Lys Arg Ile Tyr Phe  Arg Leu Arg 
    1580                 1585                 1590             


Asn Lys  Ala Thr Gly Leu Phe  Met Ser Thr Asn Gly  Asn Leu Glu 
    1595                 1600                 1605             


Asp Leu  Lys Leu Leu Arg Ile  Gln Val Met Glu Asp  Val Gly Ala 
    1610                 1615                 1620             


Asp Asp  Gln Ile Trp Ile Tyr  Gln Glu Gly Cys Ile  Lys Cys Arg 
    1625                 1630                 1635             


Ile Ala  Glu Asp Cys Cys Leu  Thr Ile Val Gly Ser  Leu Val Thr 
    1640                 1645                 1650             


Ser Gly  Ser Lys Leu Gly Leu  Ala Leu Asp Gln Asn  Ala Asp Ser 
    1655                 1660                 1665             


Gln Phe  Trp Ser Leu Lys Ser  Asp Gly Arg Ile Tyr  Ser Lys Leu 
    1670                 1675                 1680             


Lys Pro  Asn Leu Val Leu Asp  Ile Lys Gly Gly Thr  Gln Tyr Asp 
    1685                 1690                 1695             


Gln Asn  His Ile Ile Leu Asn  Thr Val Ser Lys Glu  Lys Phe Thr 
    1700                 1705                 1710             


Gln Val  Trp Glu Ala Met Val  Leu Tyr Thr 
    1715                 1720             


<210>  378
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIM2__Homo_sapiens__NP_004824

<400>  378

Met Glu Ser Lys Tyr Lys Glu Ile Leu Leu Leu Thr Gly Leu Asp Asn 
1               5                   10                  15      


Ile Thr Asp Glu Glu Leu Asp Arg Phe Lys Phe Phe Leu Ser Asp Glu 
            20                  25                  30          


Phe Asn Ile Ala Thr Gly Lys Leu His Thr Ala Asn Arg Ile Gln Val 
        35                  40                  45              


Ala Thr Leu Met Ile Gln Asn Ala Gly Ala Val Ser Ala Val Met Lys 
    50                  55                  60                  


Thr Ile Arg Ile Phe Gln Lys Leu Asn Tyr Met Leu Leu Ala Lys Arg 
65                  70                  75                  80  


Leu Gln Glu Glu Lys Glu Lys Val Asp Lys Gln Tyr Lys Ser Val Thr 
                85                  90                  95      


Lys Pro Lys Pro Leu Ser Gln Ala Glu Met Ser Pro Ala Ala Ser Ala 
            100                 105                 110         


Ala Ile Arg Asn Asp Val Ala Lys Gln Arg Ala Ala Pro Lys Val Ser 
        115                 120                 125             


Pro His Val Lys Pro Glu Gln Lys Gln Met Val Ala Gln Gln Glu Ser 
    130                 135                 140                 


Ile Arg Glu Gly Phe Gln Lys Arg Cys Leu Pro Val Met Val Leu Lys 
145                 150                 155                 160 


Ala Lys Lys Pro Phe Thr Phe Glu Thr Gln Glu Gly Lys Gln Glu Met 
                165                 170                 175     


Phe His Ala Thr Val Ala Thr Glu Lys Glu Phe Phe Phe Val Lys Val 
            180                 185                 190         


Phe Asn Thr Leu Leu Lys Asp Lys Phe Ile Pro Lys Arg Ile Ile Ile 
        195                 200                 205             


Ile Ala Arg Tyr Tyr Arg His Ser Gly Phe Leu Glu Val Asn Ser Ala 
    210                 215                 220                 


Ser Arg Val Leu Asp Ala Glu Ser Asp Gln Lys Val Asn Val Pro Leu 
225                 230                 235                 240 


Asn Ile Ile Arg Lys Ala Gly Glu Thr Pro Lys Ile Asn Thr Leu Gln 
                245                 250                 255     


Thr Gln Pro Leu Gly Thr Ile Val Asn Gly Leu Phe Val Val Gln Lys 
            260                 265                 270         


Val Thr Glu Lys Lys Lys Asn Ile Leu Phe Asp Leu Ser Asp Asn Thr 
        275                 280                 285             


Gly Lys Met Glu Val Leu Gly Val Arg Asn Glu Asp Thr Met Lys Cys 
    290                 295                 300                 


Lys Glu Gly Asp Lys Val Arg Leu Thr Phe Phe Thr Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Glu Lys Leu Gln Leu Thr Ser Gly Val His Ser Thr Ile Lys Val 
                325                 330                 335     


Ile Lys Ala Lys Lys Lys Thr 
            340             


<210>  379
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP1__Homo_sapiens__NP_001135887

<400>  379

Met Ala Asn Asn Asp Ala Val Leu Lys Arg Leu Glu Gln Lys Gly Ala 
1               5                   10                  15      


Glu Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val Ser Leu Leu 
            20                  25                  30          


Lys Glu Lys Ala Ile Leu Gln Ala Thr Leu Arg Glu Glu Lys Lys Leu 
        35                  40                  45              


Arg Val Glu Asn Ala Lys Leu Lys Lys Glu Ile Glu Glu Leu Lys Gln 
    50                  55                  60                  


Glu Leu Ile Gln Ala Glu Ile Gln Asn Gly Val Lys Gln Ile Pro Phe 
65                  70                  75                  80  


Pro Ser Gly Thr Pro Leu His Ala Asn Ser Met Val Ser Glu Asn Val 
                85                  90                  95      


Ile Gln Ser Thr Ala Val Thr Thr Val Ser Ser Gly Thr Lys Glu Gln 
            100                 105                 110         


Ile Lys Gly Gly Thr Gly Asp Glu Lys Lys Ala Lys Glu Lys Ile Glu 
        115                 120                 125             


Lys Lys Gly Glu Lys Lys Glu Lys Lys Gln Gln Ser Ile Ala Gly Ser 
    130                 135                 140                 


Ala Asp Ser Lys Pro Ile Asp Val Ser Arg Leu Asp Leu Arg Ile Gly 
145                 150                 155                 160 


Cys Ile Ile Thr Ala Arg Lys His Pro Asp Ala Asp Ser Leu Tyr Val 
                165                 170                 175     


Glu Glu Val Asp Val Gly Glu Ile Ala Pro Arg Thr Val Val Ser Gly 
            180                 185                 190         


Leu Val Asn His Val Pro Leu Glu Gln Met Gln Asn Arg Met Val Ile 
        195                 200                 205             


Leu Leu Cys Asn Leu Lys Pro Ala Lys Met Arg Gly Val Leu Ser Gln 
    210                 215                 220                 


Ala Met Val Met Cys Ala Ser Ser Pro Glu Lys Ile Glu Ile Leu Ala 
225                 230                 235                 240 


Pro Pro Asn Gly Ser Val Pro Gly Asp Arg Ile Thr Phe Asp Ala Phe 
                245                 250                 255     


Pro Gly Glu Pro Asp Lys Glu Leu Asn Pro Lys Lys Lys Ile Trp Glu 
            260                 265                 270         


Gln Ile Gln Pro Asp Leu His Thr Asn Asp Glu Cys Val Ala Thr Tyr 
        275                 280                 285             


Lys Gly Val Pro Phe Glu Val Lys Gly Lys Gly Val Cys Arg Ala Gln 
    290                 295                 300                 


Thr Met Ser Asn Ser Gly Ile Lys 
305                 310         


<210>  380
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIMP2__Homo_sapiens__NP_006294

<400>  380

Met Pro Met Tyr Gln Val Lys Pro Tyr His Gly Gly Gly Ala Pro Leu 
1               5                   10                  15      


Arg Val Glu Leu Pro Thr Cys Met Tyr Arg Leu Pro Asn Val His Gly 
            20                  25                  30          


Arg Ser Tyr Gly Pro Ala Pro Gly Ala Gly His Val Gln Glu Glu Ser 
        35                  40                  45              


Asn Leu Ser Leu Gln Ala Leu Glu Ser Arg Gln Asp Asp Ile Leu Lys 
    50                  55                  60                  


Arg Leu Tyr Glu Leu Lys Ala Ala Val Asp Gly Leu Ser Lys Met Ile 
65                  70                  75                  80  


Gln Thr Pro Asp Ala Asp Leu Asp Val Thr Asn Ile Ile Gln Ala Asp 
                85                  90                  95      


Glu Pro Thr Thr Leu Thr Thr Asn Ala Leu Asp Leu Asn Ser Val Leu 
            100                 105                 110         


Gly Lys Asp Tyr Gly Ala Leu Lys Asp Ile Val Ile Asn Ala Asn Pro 
        115                 120                 125             


Ala Ser Pro Pro Leu Ser Leu Leu Val Leu His Arg Leu Leu Cys Glu 
    130                 135                 140                 


His Phe Arg Val Leu Ser Thr Val His Thr His Ser Ser Val Lys Ser 
145                 150                 155                 160 


Val Pro Glu Asn Leu Leu Lys Cys Phe Gly Glu Gln Asn Lys Lys Gln 
                165                 170                 175     


Pro Arg Gln Asp Tyr Gln Leu Gly Phe Thr Leu Ile Trp Lys Asn Val 
            180                 185                 190         


Pro Lys Thr Gln Met Lys Phe Ser Ile Gln Thr Met Cys Pro Ile Glu 
        195                 200                 205             


Gly Glu Gly Asn Ile Ala Arg Phe Leu Phe Ser Leu Phe Gly Gln Lys 
    210                 215                 220                 


His Asn Ala Val Asn Ala Thr Leu Ile Asp Ser Trp Val Asp Ile Ala 
225                 230                 235                 240 


Ile Phe Gln Leu Lys Glu Gly Ser Ser Lys Glu Lys Ala Ala Val Phe 
                245                 250                 255     


Arg Ser Met Asn Ser Ala Leu Gly Lys Ser Pro Trp Leu Ala Gly Asn 
            260                 265                 270         


Glu Leu Thr Val Ala Asp Val Val Leu Trp Ser Val Leu Gln Gln Ile 
        275                 280                 285             


Gly Gly Cys Ser Val Thr Val Pro Ala Asn Val Gln Arg Trp Met Arg 
    290                 295                 300                 


Ser Cys Glu Asn Leu Ala Pro Phe Asn Thr Ala Leu Lys Leu Leu Lys 
305                 310                 315                 320 


<210>  381
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIP__Homo_sapiens__NP_003968

<400>  381

Met Ala Asp Ile Ile Ala Arg Leu Arg Glu Asp Gly Ile Gln Lys Arg 
1               5                   10                  15      


Val Ile Gln Glu Gly Arg Gly Glu Leu Pro Asp Phe Gln Asp Gly Thr 
            20                  25                  30          


Lys Ala Thr Phe His Tyr Arg Thr Leu His Ser Asp Asp Glu Gly Thr 
        35                  40                  45              


Val Leu Asp Asp Ser Arg Ala Arg Gly Lys Pro Met Glu Leu Ile Ile 
    50                  55                  60                  


Gly Lys Lys Phe Lys Leu Pro Val Trp Glu Thr Ile Val Cys Thr Met 
65                  70                  75                  80  


Arg Glu Gly Glu Ile Ala Gln Phe Leu Cys Asp Ile Lys His Val Val 
                85                  90                  95      


Leu Tyr Pro Leu Val Ala Lys Ser Leu Arg Asn Ile Ala Val Gly Lys 
            100                 105                 110         


Asp Pro Leu Glu Gly Gln Arg His Cys Cys Gly Val Ala Gln Met Arg 
        115                 120                 125             


Glu His Ser Ser Leu Gly His Ala Asp Leu Asp Ala Leu Gln Gln Asn 
    130                 135                 140                 


Pro Gln Pro Leu Ile Phe His Met Glu Met Leu Lys Val Glu Ser Pro 
145                 150                 155                 160 


Gly Thr Tyr Gln Gln Asp Pro Trp Ala Met Thr Asp Glu Glu Lys Ala 
                165                 170                 175     


Lys Ala Val Pro Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg Glu 
            180                 185                 190         


Gly His Val Lys Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala Cys 
        195                 200                 205             


Leu Lys Asn Leu Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp Ile 
    210                 215                 220                 


Gln Leu Asp Gln Gln Ile Thr Pro Leu Leu Leu Asn Tyr Cys Gln Cys 
225                 230                 235                 240 


Lys Leu Val Val Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser Ser 
                245                 250                 255     


Ile Leu Asn Lys Tyr Asp Asp Asn Val Lys Ala Tyr Phe Lys Arg Gly 
            260                 265                 270         


Lys Ala His Ala Ala Val Trp Asn Ala Gln Glu Ala Gln Ala Asp Phe 
        275                 280                 285             


Ala Lys Val Leu Glu Leu Asp Pro Ala Leu Ala Pro Val Val Ser Arg 
    290                 295                 300                 


Glu Leu Arg Ala Leu Glu Ala Arg Ile Arg Gln Lys Asp Glu Glu Asp 
305                 310                 315                 320 


Lys Ala Arg Phe Arg Gly Ile Phe Ser His 
                325                 330 


<210>  382
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIPL1__Homo_sapiens__NP_001028226

<400>  382

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 
        35                  40                  45              


Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 
    50                  55                  60                  


Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg 
65                  70                  75                  80  


Val His Glu Val Ala Glu Phe Trp Cys Asp Thr Ile Val Asp Ala Pro 
                85                  90                  95      


Ser Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met 
            100                 105                 110         


Lys Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu 
        115                 120                 125             


Gly Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys 
    130                 135                 140                 


Leu Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp Leu 
145                 150                 155                 160 


Lys Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr Cys Gln Cys 
                165                 170                 175     


Leu Leu Lys Lys Glu Glu Tyr Tyr Glu Val Leu Glu His Thr Ser Asp 
            180                 185                 190         


Ile Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr Val Arg Ala 
        195                 200                 205             


Arg Ala His Ala Glu Val Trp Asn Glu Ala Glu Ala Lys Ala Asp Leu 
    210                 215                 220                 


Gln Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg 
225                 230                 235                 240 


Glu Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu 
                245                 250                 255     


Arg Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr Gln Pro Pro 
            260                 265                 270         


Ala Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr Glu Pro Pro 
        275                 280                 285             


Ala Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala Gly Pro Pro 
    290                 295                 300                 


Ala Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His Ser Leu Gln 
305                 310                 315                 320 


His 
    


<210>  383
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIRE__Homo_sapiens__NP_000374

<400>  383

Met Ala Thr Asp Ala Ala Leu Arg Arg Leu Leu Arg Leu His Arg Thr 
1               5                   10                  15      


Glu Ile Ala Val Ala Val Asp Ser Ala Phe Pro Leu Leu His Ala Leu 
            20                  25                  30          


Ala Asp His Asp Val Val Pro Glu Asp Lys Phe Gln Glu Thr Leu His 
        35                  40                  45              


Leu Lys Glu Lys Glu Gly Cys Pro Gln Ala Phe His Ala Leu Leu Ser 
    50                  55                  60                  


Trp Leu Leu Thr Gln Asp Ser Thr Ala Ile Leu Asp Phe Trp Arg Val 
65                  70                  75                  80  


Leu Phe Lys Asp Tyr Asn Leu Glu Arg Tyr Gly Arg Leu Gln Pro Ile 
                85                  90                  95      


Leu Asp Ser Phe Pro Lys Asp Val Asp Leu Ser Gln Pro Arg Lys Gly 
            100                 105                 110         


Arg Lys Pro Pro Ala Val Pro Lys Ala Leu Val Pro Pro Pro Arg Leu 
        115                 120                 125             


Pro Thr Lys Arg Lys Ala Ser Glu Glu Ala Arg Ala Ala Ala Pro Ala 
    130                 135                 140                 


Ala Leu Thr Pro Arg Gly Thr Ala Ser Pro Gly Ser Gln Leu Lys Ala 
145                 150                 155                 160 


Lys Pro Pro Lys Lys Pro Glu Ser Ser Ala Glu Gln Gln Arg Leu Pro 
                165                 170                 175     


Leu Gly Asn Gly Ile Gln Thr Met Ser Ala Ser Val Gln Arg Ala Val 
            180                 185                 190         


Ala Met Ser Ser Gly Asp Val Pro Gly Ala Arg Gly Ala Val Glu Gly 
        195                 200                 205             


Ile Leu Ile Gln Gln Val Phe Glu Ser Gly Gly Ser Lys Lys Cys Ile 
    210                 215                 220                 


Gln Val Gly Gly Glu Phe Tyr Thr Pro Ser Lys Phe Glu Asp Ser Gly 
225                 230                 235                 240 


Ser Gly Lys Asn Lys Ala Arg Ser Ser Ser Gly Pro Lys Pro Leu Val 
                245                 250                 255     


Arg Ala Lys Gly Ala Gln Gly Ala Ala Pro Gly Gly Gly Glu Ala Arg 
            260                 265                 270         


Leu Gly Gln Gln Gly Ser Val Pro Ala Pro Leu Ala Leu Pro Ser Asp 
        275                 280                 285             


Pro Gln Leu His Gln Lys Asn Glu Asp Glu Cys Ala Val Cys Arg Asp 
    290                 295                 300                 


Gly Gly Glu Leu Ile Cys Cys Asp Gly Cys Pro Arg Ala Phe His Leu 
305                 310                 315                 320 


Ala Cys Leu Ser Pro Pro Leu Arg Glu Ile Pro Ser Gly Thr Trp Arg 
                325                 330                 335     


Cys Ser Ser Cys Leu Gln Ala Thr Val Gln Glu Val Gln Pro Arg Ala 
            340                 345                 350         


Glu Glu Pro Arg Pro Gln Glu Pro Pro Val Glu Thr Pro Leu Pro Pro 
        355                 360                 365             


Gly Leu Arg Ser Ala Gly Glu Glu Val Arg Gly Pro Pro Gly Glu Pro 
    370                 375                 380                 


Leu Ala Gly Met Asp Thr Thr Leu Val Tyr Lys His Leu Pro Ala Pro 
385                 390                 395                 400 


Pro Ser Ala Ala Pro Leu Pro Gly Leu Asp Ser Ser Ala Leu His Pro 
                405                 410                 415     


Leu Leu Cys Val Gly Pro Glu Gly Gln Gln Asn Leu Ala Pro Gly Ala 
            420                 425                 430         


Arg Cys Gly Val Cys Gly Asp Gly Thr Asp Val Leu Arg Cys Thr His 
        435                 440                 445             


Cys Ala Ala Ala Phe His Trp Arg Cys His Phe Pro Ala Gly Thr Ser 
    450                 455                 460                 


Arg Pro Gly Thr Gly Leu Arg Cys Arg Ser Cys Ser Gly Asp Val Thr 
465                 470                 475                 480 


Pro Ala Pro Val Glu Gly Val Leu Ala Pro Ser Pro Ala Arg Leu Ala 
                485                 490                 495     


Pro Gly Pro Ala Lys Asp Asp Thr Ala Ser His Glu Pro Ala Leu His 
            500                 505                 510         


Arg Asp Asp Leu Glu Ser Leu Leu Ser Glu His Thr Phe Asp Gly Ile 
        515                 520                 525             


Leu Gln Trp Ala Ile Gln Ser Met Ala Arg Pro Ala Ala Pro Phe Pro 
    530                 535                 540                 


Ser 
545 


<210>  384
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AJAP1__Homo_sapiens__XP_011540088

<400>  384

Met Trp Ile Gln Gln Leu Leu Gly Leu Ser Ser Met Ser Ile Arg Trp 
1               5                   10                  15      


Pro Gly Arg Pro Leu Gly Ser His Ala Trp Ile Leu Ile Ala Met Phe 
            20                  25                  30          


Gln Leu Ala Val Asp Leu Pro Ala Cys Glu Ala Leu Gly Pro Gly Pro 
        35                  40                  45              


Glu Phe Trp Leu Leu Pro Arg Ser Pro Pro Arg Pro Pro Arg Leu Trp 
    50                  55                  60                  


Ser Phe Arg Ser Gly Gln Pro Ala Arg Val Pro Ala Pro Val Trp Ser 
65                  70                  75                  80  


Pro Arg Pro Pro Arg Val Glu Arg Ile His Gly Gln Met Gln Met Pro 
                85                  90                  95      


Arg Ala Arg Arg Ala His Arg Pro Arg Asp Gln Ala Ala Ala Leu Val 
            100                 105                 110         


Pro Lys Ala Gly Leu Ala Lys Pro Pro Ala Ala Ala Lys Ser Ser Pro 
        115                 120                 125             


Ser Leu Ala Ser Ser Ser Ser Ser Ser Ser Ser Ala Val Ala Gly Gly 
    130                 135                 140                 


Ala Pro Glu Gln Gln Ala Leu Leu Arg Arg Gly Lys Arg His Leu Gln 
145                 150                 155                 160 


Gly Asp Gly Leu Ser Ser Phe Asp Ser Arg Gly Ser Arg Pro Thr Thr 
                165                 170                 175     


Glu Thr Glu Phe Ile Ala Trp Gly Pro Thr Gly Asp Glu Glu Ala Leu 
            180                 185                 190         


Glu Ser Asn Thr Phe Pro Gly Val Tyr Gly Pro Thr Thr Val Ser Ile 
        195                 200                 205             


Leu Gln Thr Arg Lys Thr Thr Val Ala Ala Thr Thr Thr Thr Thr Thr 
    210                 215                 220                 


Thr Ala Thr Pro Met Thr Leu Gln Thr Lys Gly Phe Thr Glu Ser Leu 
225                 230                 235                 240 


Asp Pro Arg Arg Arg Ile Pro Gly Gly Val Ser Thr Thr Glu Pro Ser 
                245                 250                 255     


Thr Ser Pro Ser Asn Asn Gly Glu Val Thr Gln Pro Pro Arg Ile Leu 
            260                 265                 270         


Gly Glu Ala Ser Gly Leu Ala Val His Gln Ile Ile Thr Ile Thr Val 
        275                 280                 285             


Ser Leu Ile Met Val Ile Ala Ala Leu Ile Thr Thr Leu Val Leu Lys 
    290                 295                 300                 


Asn Cys Cys Ala Gln Ser Gly Asn Thr Arg Arg Asn Ser His Gln Arg 
305                 310                 315                 320 


Lys Thr Asn Gln Gln Glu Glu Ser Cys Gln Asn Leu Thr Asp Phe Pro 
                325                 330                 335     


Ser Ala Arg Val Pro Ser Ser Leu Asp Ile Phe Thr Ala Tyr Asn Glu 
            340                 345                 350         


Thr Leu Gln Cys Ser His Glu Cys Val Arg Ala Ser Val Pro Val Tyr 
        355                 360                 365             


Thr Asp Glu Thr Leu His Ser Thr Thr Gly Glu Tyr Lys Ser Thr Phe 
    370                 375                 380                 


Asn Gly Asn Arg Pro Ser Ser Ser Asp Arg His Leu Ile Pro Val Ala 
385                 390                 395                 400 


Phe Val Ser Glu Lys Trp Phe Glu Ile Ser Cys 
                405                 410     


<210>  385
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AJUBA__Homo_sapiens__NP_116265

<400>  385

Met Glu Arg Leu Gly Glu Lys Ala Ser Arg Leu Leu Glu Lys Phe Gly 
1               5                   10                  15      


Arg Arg Lys Gly Glu Ser Ser Arg Ser Gly Ser Asp Gly Thr Pro Gly 
            20                  25                  30          


Pro Gly Lys Gly Arg Leu Ser Gly Leu Gly Gly Pro Arg Lys Ser Gly 
        35                  40                  45              


Pro Arg Gly Ala Thr Gly Gly Pro Gly Asp Glu Pro Leu Glu Pro Ala 
    50                  55                  60                  


Arg Glu Gln Gly Ser Leu Asp Ala Glu Arg Asn Gln Arg Gly Ser Phe 
65                  70                  75                  80  


Glu Ala Pro Arg Tyr Glu Gly Ser Phe Pro Ala Gly Pro Pro Pro Thr 
                85                  90                  95      


Arg Ala Leu Pro Leu Pro Gln Ser Leu Pro Pro Asp Phe Arg Leu Glu 
            100                 105                 110         


Pro Thr Ala Pro Ala Leu Ser Pro Arg Ser Ser Phe Ala Ser Ser Ser 
        115                 120                 125             


Ala Ser Asp Ala Ser Lys Pro Ser Ser Pro Arg Gly Ser Leu Leu Leu 
    130                 135                 140                 


Asp Gly Ala Gly Ala Gly Gly Ala Gly Gly Ser Arg Pro Cys Ser Asn 
145                 150                 155                 160 


Arg Thr Ser Gly Ile Ser Met Gly Tyr Asp Gln Arg His Gly Ser Pro 
                165                 170                 175     


Leu Pro Ala Gly Pro Cys Leu Phe Gly Pro Pro Leu Ala Gly Ala Pro 
            180                 185                 190         


Ala Gly Tyr Ser Pro Gly Gly Val Pro Ser Ala Tyr Pro Glu Leu His 
        195                 200                 205             


Ala Ala Leu Asp Arg Leu Tyr Ala Gln Arg Pro Ala Gly Phe Gly Cys 
    210                 215                 220                 


Gln Glu Ser Arg His Ser Tyr Pro Pro Ala Leu Gly Ser Pro Gly Ala 
225                 230                 235                 240 


Leu Ala Gly Ala Gly Val Gly Ala Ala Gly Pro Leu Glu Arg Arg Gly 
                245                 250                 255     


Ala Gln Pro Gly Arg His Ser Val Thr Gly Tyr Gly Asp Cys Ala Val 
            260                 265                 270         


Gly Ala Arg Tyr Gln Asp Glu Leu Thr Ala Leu Leu Arg Leu Thr Val 
        275                 280                 285             


Gly Thr Gly Gly Arg Glu Ala Gly Ala Arg Gly Glu Pro Ser Gly Ile 
    290                 295                 300                 


Glu Pro Ser Gly Leu Glu Glu Pro Pro Gly Pro Phe Val Pro Glu Ala 
305                 310                 315                 320 


Ala Arg Ala Arg Met Arg Glu Pro Glu Ala Arg Glu Asp Tyr Phe Gly 
                325                 330                 335     


Thr Cys Ile Lys Cys Asn Lys Gly Ile Tyr Gly Gln Ser Asn Ala Cys 
            340                 345                 350         


Gln Ala Leu Asp Ser Leu Tyr His Thr Gln Cys Phe Val Cys Cys Ser 
        355                 360                 365             


Cys Gly Arg Thr Leu Arg Cys Lys Ala Phe Tyr Ser Val Asn Gly Ser 
    370                 375                 380                 


Val Tyr Cys Glu Glu Asp Tyr Leu Phe Ser Gly Phe Gln Glu Ala Ala 
385                 390                 395                 400 


Glu Lys Cys Cys Val Cys Gly His Leu Ile Leu Glu Lys Ile Leu Gln 
                405                 410                 415     


Ala Met Gly Lys Ser Tyr His Pro Gly Cys Phe Arg Cys Ile Val Cys 
            420                 425                 430         


Asn Lys Cys Leu Asp Gly Ile Pro Phe Thr Val Asp Phe Ser Asn Gln 
        435                 440                 445             


Val Tyr Cys Val Thr Asp Tyr His Lys Asn Tyr Ala Pro Lys Cys Ala 
    450                 455                 460                 


Ala Cys Gly Gln Pro Ile Leu Pro Ser Glu Gly Cys Glu Asp Ile Val 
465                 470                 475                 480 


Arg Val Ile Ser Met Asp Arg Asp Tyr His Phe Glu Cys Tyr His Cys 
                485                 490                 495     


Glu Asp Cys Arg Met Gln Leu Ser Asp Glu Glu Gly Cys Cys Cys Phe 
            500                 505                 510         


Pro Leu Asp Gly His Leu Leu Cys His Gly Cys His Met Gln Arg Leu 
        515                 520                 525             


Asn Ala Arg Gln Pro Pro Ala Asn Tyr Ile 
    530                 535             


<210>  386
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AK1__Homo_sapiens__NP_000467

<400>  386

Met Glu Glu Lys Leu Lys Lys Thr Lys Ile Ile Phe Val Val Gly Gly 
1               5                   10                  15      


Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Ile Val Gln Lys Tyr 
            20                  25                  30          


Gly Tyr Thr His Leu Ser Thr Gly Asp Leu Leu Arg Ser Glu Val Ser 
        35                  40                  45              


Ser Gly Ser Ala Arg Gly Lys Lys Leu Ser Glu Ile Met Glu Lys Gly 
    50                  55                  60                  


Gln Leu Val Pro Leu Glu Thr Val Leu Asp Met Leu Arg Asp Ala Met 
65                  70                  75                  80  


Val Ala Lys Val Asn Thr Ser Lys Gly Phe Leu Ile Asp Gly Tyr Pro 
                85                  90                  95      


Arg Glu Val Gln Gln Gly Glu Glu Phe Glu Arg Arg Ile Gly Gln Pro 
            100                 105                 110         


Thr Leu Leu Leu Tyr Val Asp Ala Gly Pro Glu Thr Met Thr Gln Arg 
        115                 120                 125             


Leu Leu Lys Arg Gly Glu Thr Ser Gly Arg Val Asp Asp Asn Glu Glu 
    130                 135                 140                 


Thr Ile Lys Lys Arg Leu Glu Thr Tyr Tyr Lys Ala Thr Glu Pro Val 
145                 150                 155                 160 


Ile Ala Phe Tyr Glu Lys Arg Gly Ile Val Arg Lys Val Asn Ala Glu 
                165                 170                 175     


Gly Ser Val Asp Ser Val Phe Ser Gln Val Cys Thr His Leu Asp Ala 
            180                 185                 190         


Leu Lys 
        


<210>  387
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AK3__Homo_sapiens__NP_001186781

<400>  387

Met Gly Ala Ser Ala Arg Leu Leu Arg Ala Val Ile Met Gly Ala Pro 
1               5                   10                  15      


Gly Ser Gly Lys Gly Thr Val Ser Ser Arg Ile Thr Thr His Phe Glu 
            20                  25                  30          


Leu Lys His Leu Ser Ser Gly Asp Leu Leu Arg Asp Asn Met Leu Arg 
        35                  40                  45              


Gly Thr Gly Phe Pro Arg Thr Leu Pro Gln Ala Glu Ala Leu Asp Arg 
    50                  55                  60                  


Ala Tyr Gln Ile Asp Thr Val Ile Asn Leu Asn Val Pro Phe Glu Val 
65                  70                  75                  80  


Ile Lys Gln Arg Leu Thr Ala Arg Trp Ile His Pro Ala Ser Gly Arg 
                85                  90                  95      


Val Tyr Asn Ile Glu Phe Asn Pro Pro Lys Thr Val Gly Ile Asp Asp 
            100                 105                 110         


Leu Thr Gly Glu Pro Leu Ile Gln Arg Glu Asp Asp Lys Pro Glu Thr 
        115                 120                 125             


Val Ile Lys Arg Leu Lys Ala Tyr Glu Asp Gln Thr Lys Pro Val Leu 
    130                 135                 140                 


Glu Tyr Tyr Gln Lys Lys Gly Val Leu Glu Thr Phe Ser Gly Thr Glu 
145                 150                 155                 160 


Thr Asn Lys Ile Trp Pro Tyr Val Tyr Ala Phe Leu Gln Thr Lys Val 
                165                 170                 175     


Pro Gln Arg Ser Gln Lys Ala Ser Val Thr Pro 
            180                 185         


<210>  388
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AK6__Homo_sapiens__NP_001015891

<400>  388

Met Cys His Arg Lys Pro Gly Thr Pro Gly Val Gly Lys Thr Thr Leu 
1               5                   10                  15      


Gly Lys Glu Leu Ala Ser Lys Ser Gly Leu Lys Tyr Ile Asn Val Gly 
            20                  25                  30          


Asp Leu Ala Arg Glu Glu Gln Leu Tyr Asp Gly Tyr Asp Glu Glu Tyr 
        35                  40                  45              


Asp Cys Pro Ile Leu Asp Glu Asp Arg Val Val Asp Glu Leu Asp Asn 
    50                  55                  60                  


Gln Met Arg Glu Gly Gly Val Ile Val Asp Tyr His Gly Cys Asp Phe 
65                  70                  75                  80  


Phe Pro Glu Arg Trp Phe His Ile Val Phe Val Leu Arg Thr Asp Thr 
                85                  90                  95      


Asn Val Leu Tyr Glu Arg Leu Glu Thr Arg Gly Tyr Asn Glu Lys Lys 
            100                 105                 110         


Leu Thr Asp Asn Ile Gln Cys Glu Ile Phe Gln Val Leu Tyr Glu Glu 
        115                 120                 125             


Ala Thr Ala Ser Tyr Lys Glu Glu Ile Val His Gln Leu Pro Ser Asn 
    130                 135                 140                 


Lys Pro Glu Glu Leu Glu Asn Asn Val Asp Gln Ile Leu Lys Trp Ile 
145                 150                 155                 160 


Glu Gln Trp Ile Lys Asp His Asn Ser 
                165                 


<210>  389
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AK7__Homo_sapiens__NP_689540

<400>  389

Met Ala Glu Glu Glu Glu Thr Ala Ala Leu Thr Glu Lys Val Ile Arg 
1               5                   10                  15      


Thr Gln Arg Val Phe Ile Asn Leu Leu Asp Ser Tyr Ser Ser Gly Asn 
            20                  25                  30          


Ile Gly Lys Phe Leu Ser Asn Cys Val Val Gly Ala Ser Leu Glu Glu 
        35                  40                  45              


Ile Thr Glu Glu Glu Glu Glu Glu Asp Glu Asn Lys Ser Ala Met Leu 
    50                  55                  60                  


Glu Ala Ser Ser Thr Lys Val Lys Glu Gly Thr Phe Gln Ile Val Gly 
65                  70                  75                  80  


Thr Leu Ser Lys Pro Asp Ser Pro Arg Pro Asp Phe Ala Val Glu Thr 
                85                  90                  95      


Tyr Ser Ala Ile Ser Arg Glu Asp Leu Leu Met Arg Leu Leu Glu Cys 
            100                 105                 110         


Asp Val Ile Ile Tyr Asn Ile Thr Glu Ser Ser Gln Gln Met Glu Glu 
        115                 120                 125             


Ala Ile Trp Ala Val Ser Ala Leu Ser Glu Glu Val Ser His Phe Glu 
    130                 135                 140                 


Lys Arg Lys Leu Phe Ile Leu Leu Ser Thr Val Met Thr Trp Ala Arg 
145                 150                 155                 160 


Ser Lys Ala Leu Asp Pro Glu Asp Ser Glu Val Pro Phe Thr Glu Glu 
                165                 170                 175     


Asp Tyr Arg Arg Arg Lys Ser His Pro Asn Phe Leu Asp His Ile Asn 
            180                 185                 190         


Ala Glu Lys Met Val Leu Lys Phe Gly Lys Lys Ala Arg Lys Phe Ala 
        195                 200                 205             


Ala Tyr Val Val Ala Ala Gly Leu Gln Tyr Gly Ala Glu Gly Gly Met 
    210                 215                 220                 


Leu His Thr Phe Phe Lys Met Ala Trp Leu Gly Glu Ile Pro Ala Leu 
225                 230                 235                 240 


Pro Val Phe Gly Asp Gly Thr Asn Val Ile Pro Thr Ile His Val Leu 
                245                 250                 255     


Asp Leu Ala Gly Val Ile Gln Asn Val Ile Asp His Val Pro Lys Pro 
            260                 265                 270         


His Tyr Leu Val Ala Val Asp Glu Ser Val His Thr Leu Glu Asp Ile 
        275                 280                 285             


Val Lys Cys Ile Ser Lys Asn Thr Gly Pro Gly Lys Ile Gln Lys Ile 
    290                 295                 300                 


Pro Arg Glu Asn Ala Tyr Leu Thr Lys Asp Leu Thr Gln Asp Cys Leu 
305                 310                 315                 320 


Asp His Leu Leu Val Asn Leu Arg Met Glu Ala Leu Phe Val Lys Glu 
                325                 330                 335     


Asn Phe Asn Ile Arg Trp Ala Ala Gln Thr Gly Phe Val Glu Asn Ile 
            340                 345                 350         


Asn Thr Ile Leu Lys Glu Tyr Lys Gln Ser Arg Gly Leu Met Pro Ile 
        355                 360                 365             


Lys Ile Cys Ile Leu Gly Pro Pro Ala Val Gly Lys Ser Ser Ile Ala 
    370                 375                 380                 


Lys Glu Leu Ala Asn Tyr Tyr Lys Leu His His Ile Gln Leu Lys Asp 
385                 390                 395                 400 


Val Ile Ser Glu Ala Ile Ala Lys Leu Glu Ala Ile Val Ala Pro Asn 
                405                 410                 415     


Asp Val Gly Glu Gly Glu Glu Glu Val Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Asn Val Glu Asp Ala Gln Glu Leu Leu Asp Gly Ile Lys Glu Ser Met 
        435                 440                 445             


Glu Gln Asn Ala Gly Gln Leu Asp Asp Gln Tyr Ile Ile Arg Phe Met 
    450                 455                 460                 


Lys Glu Lys Leu Lys Ser Met Pro Cys Arg Asn Gln Gly Tyr Ile Leu 
465                 470                 475                 480 


Asp Gly Phe Pro Lys Thr Tyr Asp Gln Ala Lys Asp Leu Phe Asn Gln 
                485                 490                 495     


Glu Asp Glu Glu Glu Glu Asp Asp Val Arg Gly Arg Met Phe Pro Phe 
            500                 505                 510         


Asp Lys Leu Ile Ile Pro Glu Phe Val Cys Ala Leu Asp Ala Ser Asp 
        515                 520                 525             


Glu Phe Leu Lys Glu Arg Val Ile Asn Leu Pro Glu Ser Ile Val Ala 
    530                 535                 540                 


Gly Thr His Tyr Ser Gln Asp Arg Phe Leu Arg Ala Leu Ser Asn Tyr 
545                 550                 555                 560 


Arg Asp Ile Asn Ile Asp Asp Glu Thr Val Phe Asn Tyr Phe Asp Glu 
                565                 570                 575     


Leu Glu Ile His Pro Ile His Ile Asp Val Gly Lys Leu Glu Asp Ala 
            580                 585                 590         


Gln Asn Arg Leu Ala Ile Lys Gln Leu Ile Lys Glu Ile Gly Glu Pro 
        595                 600                 605             


Arg Asn Tyr Gly Leu Thr Asp Glu Glu Lys Ala Glu Glu Glu Arg Lys 
    610                 615                 620                 


Ala Ala Glu Glu Arg Leu Ala Arg Glu Ala Ala Glu Glu Ala Glu Arg 
625                 630                 635                 640 


Glu His Gln Glu Ala Val Glu Met Ala Glu Lys Ile Ala Arg Trp Glu 
                645                 650                 655     


Glu Trp Asn Lys Arg Leu Glu Glu Val Lys Arg Glu Glu Arg Glu Leu 
            660                 665                 670         


Leu Glu Ala Gln Ser Ile Pro Leu Arg Asn Tyr Leu Met Thr Tyr Val 
        675                 680                 685             


Met Pro Thr Leu Ile Gln Gly Leu Asn Glu Cys Cys Asn Val Arg Pro 
    690                 695                 700                 


Glu Asp Pro Val Asp Phe Leu Ala Glu Tyr Leu Phe Lys Asn Asn Pro 
705                 710                 715                 720 


Glu Ala Gln 
            


<210>  390
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AK8__Homo_sapiens__NP_689785

<400>  390

Met Asp Ala Thr Ile Ala Pro His Arg Ile Pro Pro Glu Met Pro Gln 
1               5                   10                  15      


Tyr Gly Glu Glu Asn His Ile Phe Glu Leu Met Gln Asn Met Leu Glu 
            20                  25                  30          


Gln Leu Leu Ile His Gln Pro Glu Asp Pro Ile Pro Phe Met Ile Gln 
        35                  40                  45              


His Leu His Arg Asp Asn Asp Asn Val Pro Arg Ile Val Ile Leu Gly 
    50                  55                  60                  


Pro Pro Ala Ser Gly Lys Thr Thr Ile Ala Met Trp Leu Cys Lys His 
65                  70                  75                  80  


Leu Asn Ser Ser Leu Leu Thr Leu Glu Asn Leu Ile Leu Asn Glu Phe 
                85                  90                  95      


Ser Tyr Thr Ala Thr Glu Ala Arg Arg Leu Tyr Leu Gln Arg Lys Thr 
            100                 105                 110         


Val Pro Ser Ala Leu Leu Val Gln Leu Ile Gln Glu Arg Leu Ala Glu 
        115                 120                 125             


Glu Asp Cys Ile Lys Gln Gly Trp Ile Leu Asp Gly Ile Pro Glu Thr 
    130                 135                 140                 


Arg Glu Gln Ala Leu Arg Ile Gln Thr Leu Gly Ile Thr Pro Arg His 
145                 150                 155                 160 


Val Ile Val Leu Ser Ala Pro Asp Thr Val Leu Ile Glu Arg Asn Leu 
                165                 170                 175     


Gly Lys Arg Ile Asp Pro Gln Thr Gly Glu Ile Tyr His Thr Thr Phe 
            180                 185                 190         


Asp Trp Pro Pro Glu Ser Glu Ile Gln Asn Arg Leu Met Val Pro Glu 
        195                 200                 205             


Asp Ile Ser Glu Leu Glu Thr Ala Gln Lys Leu Leu Glu Tyr His Arg 
    210                 215                 220                 


Asn Ile Val Arg Val Ile Pro Ser Tyr Pro Lys Ile Leu Lys Val Ile 
225                 230                 235                 240 


Ser Ala Asp Gln Pro Cys Val Asp Val Phe Tyr Gln Ala Leu Thr Tyr 
                245                 250                 255     


Val Gln Ser Asn His Arg Thr Asn Ala Pro Phe Thr Pro Arg Val Leu 
            260                 265                 270         


Leu Leu Gly Pro Val Gly Ser Gly Lys Ser Leu Gln Ala Ala Leu Leu 
        275                 280                 285             


Ala Gln Lys Tyr Arg Leu Val Asn Val Cys Cys Gly Gln Leu Leu Lys 
    290                 295                 300                 


Glu Ala Val Ala Asp Arg Thr Thr Phe Gly Glu Leu Ile Gln Pro Phe 
305                 310                 315                 320 


Phe Glu Lys Glu Met Ala Val Pro Asp Ser Leu Leu Met Lys Val Leu 
                325                 330                 335     


Ser Gln Arg Leu Asp Gln Gln Asp Cys Ile Gln Lys Gly Trp Val Leu 
            340                 345                 350         


His Gly Val Pro Arg Asp Leu Asp Gln Ala His Leu Leu Asn Arg Leu 
        355                 360                 365             


Gly Tyr Asn Pro Asn Arg Val Phe Phe Leu Asn Val Pro Phe Asp Ser 
    370                 375                 380                 


Ile Met Glu Arg Leu Thr Leu Arg Arg Ile Asp Pro Val Thr Gly Glu 
385                 390                 395                 400 


Arg Tyr His Leu Met Tyr Lys Pro Pro Pro Thr Met Glu Ile Gln Ala 
                405                 410                 415     


Arg Leu Leu Gln Asn Pro Lys Asp Ala Glu Glu Gln Val Lys Leu Lys 
            420                 425                 430         


Met Asp Leu Phe Tyr Arg Asn Ser Ala Asp Leu Glu Gln Leu Tyr Gly 
        435                 440                 445             


Ser Ala Ile Thr Leu Asn Gly Asp Gln Asp Pro Tyr Thr Val Phe Glu 
    450                 455                 460                 


Tyr Ile Glu Ser Gly Ile Ile Asn Pro Leu Pro Lys Lys Ile Pro 
465                 470                 475                 


<210>  391
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AK9__Homo_sapiens__NP_659462

<400>  391

Met Thr Ser Gln Glu Lys Thr Glu Glu Tyr Pro Phe Ala Asp Ile Phe 
1               5                   10                  15      


Asp Glu Asp Glu Thr Glu Arg Asn Phe Leu Leu Ser Lys Pro Val Cys 
            20                  25                  30          


Phe Val Val Phe Gly Lys Pro Gly Val Gly Lys Thr Thr Leu Ala Arg 
        35                  40                  45              


Tyr Ile Thr Gln Ala Trp Lys Cys Ile Arg Val Glu Ala Leu Pro Ile 
    50                  55                  60                  


Leu Glu Glu Gln Ile Ala Ala Glu Thr Glu Ser Gly Val Met Leu Gln 
65                  70                  75                  80  


Ser Met Leu Ile Ser Gly Gln Ser Ile Pro Asp Glu Leu Val Ile Lys 
                85                  90                  95      


Leu Met Leu Glu Lys Leu Asn Ser Pro Glu Val Cys His Phe Gly Tyr 
            100                 105                 110         


Ile Ile Thr Glu Ile Pro Ser Leu Ser Gln Asp Ala Met Thr Thr Leu 
        115                 120                 125             


Gln Gln Ile Glu Leu Ile Lys Asn Leu Asn Leu Lys Pro Asp Val Ile 
    130                 135                 140                 


Ile Asn Ile Lys Cys Pro Asp Tyr Asp Leu Cys Gln Arg Ile Ser Gly 
145                 150                 155                 160 


Gln Arg Gln His Asn Asn Thr Gly Tyr Ile Tyr Ser Arg Asp Gln Trp 
                165                 170                 175     


Asp Pro Glu Val Ile Glu Asn His Arg Lys Lys Lys Lys Glu Ala Gln 
            180                 185                 190         


Lys Asp Gly Lys Gly Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu 
        195                 200                 205             


Glu Glu Ala Phe Ile Ala Glu Met Gln Met Val Ala Glu Ile Leu His 
    210                 215                 220                 


His Leu Val Gln Arg Pro Glu Asp Tyr Leu Glu Asn Val Glu Asn Ile 
225                 230                 235                 240 


Val Lys Leu Tyr Lys Glu Thr Ile Leu Gln Thr Leu Glu Glu Val Met 
                245                 250                 255     


Ala Glu His Asn Pro Gln Tyr Leu Ile Glu Leu Asn Gly Asn Lys Pro 
            260                 265                 270         


Ala Glu Glu Leu Phe Met Ile Val Met Asp Arg Leu Lys Tyr Leu Asn 
        275                 280                 285             


Leu Lys Arg Ala Ala Ile Leu Thr Lys Leu Gln Gly Ala Glu Glu Glu 
    290                 295                 300                 


Ile Asn Asp Thr Met Glu Asn Asp Glu Leu Phe Arg Thr Leu Ala Ser 
305                 310                 315                 320 


Tyr Lys Leu Ile Ala Pro Arg Tyr Arg Trp Gln Arg Ser Lys Trp Gly 
                325                 330                 335     


Arg Thr Cys Pro Val Asn Leu Lys Asp Gly Asn Ile Tyr Ser Gly Leu 
            340                 345                 350         


Pro Asp Tyr Ser Val Ser Phe Leu Gly Lys Ile Tyr Cys Leu Ser Ser 
        355                 360                 365             


Glu Glu Ala Leu Lys Pro Phe Leu Leu Asn Pro Arg Pro Tyr Leu Leu 
    370                 375                 380                 


Pro Pro Met Pro Gly Pro Pro Cys Lys Val Phe Ile Leu Gly Pro Gln 
385                 390                 395                 400 


Tyr Ser Gly Lys Thr Thr Leu Cys Asn Met Leu Ala Glu Asn Tyr Lys 
                405                 410                 415     


Gly Lys Val Thr Asn 
            420     


<210>  392
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP10__Homo_sapiens__NP_009133

<400>  392

Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg 
1               5                   10                  15      


Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly 
            20                  25                  30          


Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Ala Ser Ile 
        35                  40                  45              


Ser Val His Ser Pro Gln Lys Ser Thr Lys Asn His Ala Leu Leu Glu 
    50                  55                  60                  


Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met 
65                  70                  75                  80  


Asp Ser Phe Ser Ser Ser Arg Thr Ala Thr Leu Lys Lys Gln Pro Ser 
                85                  90                  95      


His Met Glu Ala Ala His Phe Gly Asp Leu Gly Arg Ser Cys Leu Asp 
            100                 105                 110         


Tyr Gln Thr Gln Glu Thr Lys Ser Ser Leu Ser Lys Thr Leu Glu Gln 
        115                 120                 125             


Val Leu His Asp Thr Ile Val Leu Pro Tyr Phe Ile Gln Phe Met Glu 
    130                 135                 140                 


Leu Arg Arg Met Glu His Leu Val Lys Phe Trp Leu Glu Ala Glu Ser 
145                 150                 155                 160 


Phe His Ser Thr Thr Trp Ser Arg Ile Arg Ala His Ser Leu Asn Thr 
                165                 170                 175     


Val Lys Gln Ser Ser Leu Ala Glu Pro Val Ser Pro Ser Lys Lys His 
            180                 185                 190         


Glu Thr Thr Ala Ser Phe Leu Thr Asp Ser Leu Asp Lys Arg Leu Glu 
        195                 200                 205             


Asp Ser Gly Ser Ala Gln Leu Phe Met Thr His Ser Glu Gly Ile Asp 
    210                 215                 220                 


Leu Asn Asn Arg Thr Asn Ser Thr Gln Asn His Leu Leu Leu Ser Gln 
225                 230                 235                 240 


Glu Cys Asp Ser Ala His Ser Leu Arg Leu Glu Met Ala Arg Ala Gly 
                245                 250                 255     


Thr His Gln Val Ser Met Glu Thr Gln Glu Ser Ser Ser Thr Leu Thr 
            260                 265                 270         


Val Ala Ser Arg Asn Ser Pro Ala Ser Pro Leu Lys Glu Leu Ser Gly 
        275                 280                 285             


Lys Leu Met Lys Ser Ile Glu Gln Asp Ala Val Asn Thr Phe Thr Lys 
    290                 295                 300                 


Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Thr Glu Ala Met 
305                 310                 315                 320 


Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln Val Asp 
                325                 330                 335     


Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala Met Glu 
            340                 345                 350         


Gln Glu His Phe Ser Glu Phe Leu Arg Ser His His Phe Cys Lys Tyr 
        355                 360                 365             


Gln Ile Glu Val Leu Thr Ser Gly Thr Val Tyr Leu Ala Asp Ile Leu 
    370                 375                 380                 


Phe Cys Glu Ser Ala Leu Phe Tyr Phe Ser Glu Tyr Met Glu Lys Glu 
385                 390                 395                 400 


Asp Ala Val Asn Ile Leu Gln Phe Trp Leu Ala Ala Asp Asn Phe Gln 
                405                 410                 415     


Ser Gln Leu Ala Ala Lys Lys Gly Gln Tyr Asp Gly Gln Glu Ala Gln 
            420                 425                 430         


Asn Asp Ala Met Ile Leu Tyr Asp Lys Tyr Phe Ser Leu Gln Ala Thr 
        435                 440                 445             


His Pro Leu Gly Phe Asp Asp Val Val Arg Leu Glu Ile Glu Ser Asn 
    450                 455                 460                 


Ile Cys Arg Glu Gly Gly Pro Leu Pro Asn Cys Phe Thr Thr Pro Leu 
465                 470                 475                 480 


Arg Gln Ala Trp Thr Thr Met Glu Lys Val Phe Leu Pro Gly Phe Leu 
                485                 490                 495     


Ser Ser Asn Leu Tyr Tyr Lys Tyr Leu Asn Asp Leu Ile His Ser Val 
            500                 505                 510         


Arg Gly Asp Glu Phe Leu Gly Gly Asn Val Ser Leu Thr Ala Pro Gly 
        515                 520                 525             


Ser Val Gly Pro Pro Asp Glu Ser His Pro Gly Ser Ser Asp Ser Ser 
    530                 535                 540                 


Ala Ser Gln Ser Ser Val Lys Lys Ala Ser Ile Lys Ile Leu Lys Asn 
545                 550                 555                 560 


Phe Asp Glu Ala Ile Ile Val Asp Ala Ala Ser Leu Asp Pro Glu Ser 
                565                 570                 575     


Leu Tyr Gln Arg Thr Tyr Ala Gly Lys Met Thr Phe Gly Arg Val Ser 
            580                 585                 590         


Asp Leu Gly Gln Phe Ile Arg Glu Ser Glu Pro Glu Pro Asp Val Arg 
        595                 600                 605             


Lys Ser Lys Gly Ser Met Phe Ser Gln Ala Met Lys Lys Trp Val Gln 
    610                 615                 620                 


Gly Asn Thr Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys 
625                 630                 635                 640 


Met Ile Val Ser Asp Ile Met Gln Gln Ala Gln Tyr Asp Gln Pro Leu 
                645                 650                 655     


Glu Lys Ser Thr Lys Leu 
            660         


<210>  393
<211>  1782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP12__Homo_sapiens__NP_005091

<400>  393

Met Gly Ala Gly Ser Ser Thr Glu Gln Arg Ser Pro Glu Gln Pro Pro 
1               5                   10                  15      


Glu Gly Ser Ser Thr Pro Ala Glu Pro Glu Pro Ser Gly Gly Gly Pro 
            20                  25                  30          


Ser Ala Glu Ala Ala Pro Asp Thr Thr Ala Asp Pro Ala Ile Ala Ala 
        35                  40                  45              


Ser Asp Pro Ala Thr Lys Leu Leu Gln Lys Asn Gly Gln Leu Ser Thr 
    50                  55                  60                  


Ile Asn Gly Val Ala Glu Gln Asp Glu Leu Ser Leu Gln Glu Gly Asp 
65                  70                  75                  80  


Leu Asn Gly Gln Lys Gly Ala Leu Asn Gly Gln Gly Ala Leu Asn Ser 
                85                  90                  95      


Gln Glu Glu Glu Glu Val Ile Val Thr Glu Val Gly Gln Arg Asp Ser 
            100                 105                 110         


Glu Asp Val Ser Lys Arg Asp Ser Asp Lys Glu Met Ala Thr Lys Ser 
        115                 120                 125             


Ala Val Val His Asp Ile Thr Asp Asp Gly Gln Glu Glu Thr Pro Glu 
    130                 135                 140                 


Ile Ile Glu Gln Ile Pro Ser Ser Glu Ser Asn Leu Glu Glu Leu Thr 
145                 150                 155                 160 


Gln Pro Thr Glu Ser Gln Ala Asn Asp Ile Gly Phe Lys Lys Val Phe 
                165                 170                 175     


Lys Phe Val Gly Phe Lys Phe Thr Val Lys Lys Asp Lys Thr Glu Lys 
            180                 185                 190         


Pro Asp Thr Val Gln Leu Leu Thr Val Lys Lys Asp Glu Gly Glu Gly 
        195                 200                 205             


Ala Ala Gly Ala Gly Asp His Lys Asp Pro Ser Leu Gly Ala Gly Glu 
    210                 215                 220                 


Ala Ala Ser Lys Glu Ser Glu Pro Lys Gln Ser Thr Glu Lys Pro Glu 
225                 230                 235                 240 


Glu Thr Leu Lys Arg Glu Gln Ser His Ala Glu Ile Ser Pro Pro Ala 
                245                 250                 255     


Glu Ser Gly Gln Ala Val Glu Glu Cys Lys Glu Glu Gly Glu Glu Lys 
            260                 265                 270         


Gln Glu Lys Glu Pro Ser Lys Ser Ala Glu Ser Pro Thr Ser Pro Val 
        275                 280                 285             


Thr Ser Glu Thr Gly Ser Thr Phe Lys Lys Phe Phe Thr Gln Gly Trp 
    290                 295                 300                 


Ala Gly Trp Arg Lys Lys Thr Ser Phe Arg Lys Pro Lys Glu Asp Glu 
305                 310                 315                 320 


Val Glu Ala Ser Glu Lys Lys Lys Glu Gln Glu Pro Glu Lys Val Asp 
                325                 330                 335     


Thr Glu Glu Asp Gly Lys Ala Glu Val Ala Ser Glu Lys Leu Thr Ala 
            340                 345                 350         


Ser Glu Gln Ala His Pro Gln Glu Pro Ala Glu Ser Ala His Glu Pro 
        355                 360                 365             


Arg Leu Ser Ala Glu Tyr Glu Lys Val Glu Leu Pro Ser Glu Glu Gln 
    370                 375                 380                 


Val Ser Gly Ser Gln Gly Pro Ser Glu Glu Lys Pro Ala Pro Leu Ala 
385                 390                 395                 400 


Thr Glu Val Phe Asp Glu Lys Ile Glu Val His Gln Glu Glu Val Val 
                405                 410                 415     


Ala Glu Val His Val Ser Thr Val Glu Glu Arg Thr Glu Glu Gln Lys 
            420                 425                 430         


Thr Glu Val Glu Glu Thr Ala Gly Ser Val Pro Ala Glu Glu Leu Val 
        435                 440                 445             


Glu Met Asp Ala Glu Pro Gln Glu Ala Glu Pro Ala Lys Glu Leu Val 
    450                 455                 460                 


Lys Leu Lys Glu Thr Cys Val Ser Gly Glu Asp Pro Thr Gln Gly Ala 
465                 470                 475                 480 


Asp Leu Ser Pro Asp Glu Lys Val Leu Ser Lys Pro Pro Glu Gly Val 
                485                 490                 495     


Val Ser Glu Val Glu Met Leu Ser Ser Gln Glu Arg Met Lys Val Gln 
            500                 505                 510         


Gly Ser Pro Leu Lys Lys Leu Phe Thr Ser Thr Gly Leu Lys Lys Leu 
        515                 520                 525             


Ser Gly Lys Lys Gln Lys Gly Lys Arg Gly Gly Gly Asp Glu Glu Ser 
    530                 535                 540                 


Gly Glu His Thr Gln Val Pro Ala Asp Ser Pro Asp Ser Gln Glu Glu 
545                 550                 555                 560 


Gln Lys Gly Glu Ser Ser Ala Ser Ser Pro Glu Glu Pro Glu Glu Ile 
                565                 570                 575     


Thr Cys Leu Glu Lys Gly Leu Ala Glu Val Gln Gln Asp Gly Glu Ala 
            580                 585                 590         


Glu Glu Gly Ala Thr Ser Asp Gly Glu Lys Lys Arg Glu Gly Val Thr 
        595                 600                 605             


Pro Trp Ala Ser Phe Lys Lys Met Val Thr Pro Lys Lys Arg Val Arg 
    610                 615                 620                 


Arg Pro Ser Glu Ser Asp Lys Glu Asp Glu Leu Asp Lys Val Lys Ser 
625                 630                 635                 640 


Ala Thr Leu Ser Ser Thr Glu Ser Thr Ala Ser Glu Met Gln Glu Glu 
                645                 650                 655     


Met Lys Gly Ser Val Glu Glu Pro Lys Pro Glu Glu Pro Lys Arg Lys 
            660                 665                 670         


Val Asp Thr Ser Val Ser Trp Glu Ala Leu Ile Cys Val Gly Ser Ser 
        675                 680                 685             


Lys Lys Arg Ala Arg Arg Gly Ser Ser Ser Asp Glu Glu Gly Gly Pro 
    690                 695                 700                 


Lys Ala Met Gly Gly Asp His Gln Lys Ala Asp Glu Ala Gly Lys Asp 
705                 710                 715                 720 


Lys Glu Thr Gly Thr Asp Gly Ile Leu Ala Gly Ser Gln Glu His Asp 
                725                 730                 735     


Pro Gly Gln Gly Ser Ser Ser Pro Glu Gln Ala Gly Ser Pro Thr Glu 
            740                 745                 750         


Gly Glu Gly Val Ser Thr Trp Glu Ser Phe Lys Arg Leu Val Thr Pro 
        755                 760                 765             


Arg Lys Lys Ser Lys Ser Lys Leu Glu Glu Lys Ser Glu Asp Ser Ile 
    770                 775                 780                 


Ala Gly Ser Gly Val Glu His Ser Thr Pro Asp Thr Glu Pro Gly Lys 
785                 790                 795                 800 


Glu Glu Ser Trp Val Ser Ile Lys Lys Phe Ile Pro Gly Arg Arg Lys 
                805                 810                 815     


Lys Arg Pro Asp Gly Lys Gln Glu Gln Ala Pro Val Glu Asp Ala Gly 
            820                 825                 830         


Pro Thr Gly Ala Asn Glu Asp Asp Ser Asp Val Pro Ala Val Val Pro 
        835                 840                 845             


Leu Ser Glu Tyr Asp Ala Val Glu Arg Glu Lys Met Glu Ala Gln Gln 
    850                 855                 860                 


Ala Gln Lys Ser Ala Glu Gln Pro Glu Gln Lys Ala Ala Thr Glu Val 
865                 870                 875                 880 


Ser Lys Glu Leu Ser Glu Ser Gln Val His Met Met Ala Ala Ala Val 
                885                 890                 895     


Ala Asp Gly Thr Arg Ala Ala Thr Ile Ile Glu Glu Arg Ser Pro Ser 
            900                 905                 910         


Trp Ile Ser Ala Ser Val Thr Glu Pro Leu Glu Gln Val Glu Ala Glu 
        915                 920                 925             


Ala Ala Leu Leu Thr Glu Glu Val Leu Glu Arg Glu Val Ile Ala Glu 
    930                 935                 940                 


Glu Glu Pro Pro Thr Val Thr Glu Pro Leu Pro Glu Asn Arg Glu Ala 
945                 950                 955                 960 


Arg Gly Asp Thr Val Val Ser Glu Ala Glu Leu Thr Pro Glu Ala Val 
                965                 970                 975     


Thr Ala Ala Glu Thr Ala Gly Pro Leu Gly Ala Glu Glu Gly Thr Glu 
            980                 985                 990         


Ala Ser Ala Ala Glu Glu Thr Thr  Glu Met Val Ser Ala  Val Ser Gln 
        995                 1000                 1005             


Leu Thr  Asp Ser Pro Asp Thr  Thr Glu Glu Ala Thr  Pro Val Gln 
    1010                 1015                 1020             


Glu Val  Glu Gly Gly Val Pro  Asp Ile Glu Glu Gln  Glu Arg Arg 
    1025                 1030                 1035             


Thr Gln  Glu Val Leu Gln Ala  Val Ala Glu Lys Val  Lys Glu Glu 
    1040                 1045                 1050             


Ser Gln  Leu Pro Gly Thr Gly  Gly Pro Glu Asp Val  Leu Gln Pro 
    1055                 1060                 1065             


Val Gln  Arg Ala Glu Ala Glu  Arg Pro Glu Glu Gln  Ala Glu Ala 
    1070                 1075                 1080             


Ser Gly  Leu Lys Lys Glu Thr  Asp Val Val Leu Lys  Val Asp Ala 
    1085                 1090                 1095             


Gln Glu  Ala Lys Thr Glu Pro  Phe Thr Gln Gly Lys  Val Val Gly 
    1100                 1105                 1110             


Gln Thr  Thr Pro Glu Ser Phe  Glu Lys Ala Pro Gln  Val Thr Glu 
    1115                 1120                 1125             


Ser Ile  Glu Ser Ser Glu Leu  Val Thr Thr Cys Gln  Ala Glu Thr 
    1130                 1135                 1140             


Leu Ala  Gly Val Lys Ser Gln  Glu Met Val Met Glu  Gln Ala Ile 
    1145                 1150                 1155             


Pro Pro  Asp Ser Val Glu Thr  Pro Thr Asp Ser Glu  Thr Asp Gly 
    1160                 1165                 1170             


Ser Thr  Pro Val Ala Asp Phe  Asp Ala Pro Gly Thr  Thr Gln Lys 
    1175                 1180                 1185             


Asp Glu  Ile Val Glu Ile His  Glu Glu Asn Glu Val  Ala Ser Gly 
    1190                 1195                 1200             


Thr Gln  Ser Gly Gly Thr Glu  Ala Glu Ala Val Pro  Ala Gln Lys 
    1205                 1210                 1215             


Glu Arg  Pro Pro Ala Pro Ser  Ser Phe Val Phe Gln  Glu Glu Thr 
    1220                 1225                 1230             


Lys Glu  Gln Ser Lys Met Glu  Asp Thr Leu Glu His  Thr Asp Lys 
    1235                 1240                 1245             


Glu Val  Ser Val Glu Thr Val  Ser Ile Leu Ser Lys  Thr Glu Gly 
    1250                 1255                 1260             


Thr Gln  Glu Ala Asp Gln Tyr  Ala Asp Glu Lys Thr  Lys Asp Val 
    1265                 1270                 1275             


Pro Phe  Phe Glu Gly Leu Glu  Gly Ser Ile Asp Thr  Gly Ile Thr 
    1280                 1285                 1290             


Val Ser  Arg Glu Lys Val Thr  Glu Val Ala Leu Lys  Gly Glu Gly 
    1295                 1300                 1305             


Thr Glu  Glu Ala Glu Cys Lys  Lys Asp Asp Ala Leu  Glu Leu Gln 
    1310                 1315                 1320             


Ser His  Ala Lys Ser Pro Pro  Ser Pro Val Glu Arg  Glu Met Val 
    1325                 1330                 1335             


Val Gln  Val Glu Arg Glu Lys  Thr Glu Ala Glu Pro  Thr His Val 
    1340                 1345                 1350             


Asn Glu  Glu Lys Leu Glu His  Glu Thr Ala Val Thr  Val Ser Glu 
    1355                 1360                 1365             


Glu Val  Ser Lys Gln Leu Leu  Gln Thr Val Asn Val  Pro Ile Ile 
    1370                 1375                 1380             


Asp Gly  Ala Lys Glu Val Ser  Ser Leu Glu Gly Ser  Pro Pro Pro 
    1385                 1390                 1395             


Cys Leu  Gly Gln Glu Glu Ala  Val Cys Thr Lys Ile  Gln Val Gln 
    1400                 1405                 1410             


Ser Ser  Glu Ala Ser Phe Thr  Leu Thr Ala Ala Ala  Glu Glu Glu 
    1415                 1420                 1425             


Lys Val  Leu Gly Glu Thr Ala  Asn Ile Leu Glu Thr  Gly Glu Thr 
    1430                 1435                 1440             


Leu Glu  Pro Ala Gly Ala His  Leu Val Leu Glu Glu  Lys Ser Ser 
    1445                 1450                 1455             


Glu Lys  Asn Glu Asp Phe Ala  Ala His Pro Gly Glu  Asp Ala Val 
    1460                 1465                 1470             


Pro Thr  Gly Pro Asp Cys Gln  Ala Lys Ser Thr Pro  Val Ile Val 
    1475                 1480                 1485             


Ser Ala  Thr Thr Lys Lys Gly  Leu Ser Ser Asp Leu  Glu Gly Glu 
    1490                 1495                 1500             


Lys Thr  Thr Ser Leu Lys Trp  Lys Ser Asp Glu Val  Asp Glu Gln 
    1505                 1510                 1515             


Val Ala  Cys Gln Glu Val Lys  Val Ser Val Ala Ile  Glu Asp Leu 
    1520                 1525                 1530             


Glu Pro  Glu Asn Gly Ile Leu  Glu Leu Glu Thr Lys  Ser Ser Lys 
    1535                 1540                 1545             


Leu Val  Gln Asn Ile Ile Gln  Thr Ala Val Asp Gln  Phe Val Arg 
    1550                 1555                 1560             


Thr Glu  Glu Thr Ala Thr Glu  Met Leu Thr Ser Glu  Leu Gln Thr 
    1565                 1570                 1575             


Gln Ala  His Val Ile Lys Ala  Asp Ser Gln Asp Ala  Gly Gln Glu 
    1580                 1585                 1590             


Thr Glu  Lys Glu Gly Glu Glu  Pro Gln Ala Ser Ala  Gln Asp Glu 
    1595                 1600                 1605             


Thr Pro  Ile Thr Ser Ala Lys  Glu Glu Ser Glu Ser  Thr Ala Val 
    1610                 1615                 1620             


Gly Gln  Ala His Ser Asp Ile  Ser Lys Asp Met Ser  Glu Ala Ser 
    1625                 1630                 1635             


Glu Lys  Thr Met Thr Val Glu  Val Glu Gly Ser Thr  Val Asn Asp 
    1640                 1645                 1650             


Gln Gln  Leu Glu Glu Val Val  Leu Pro Ser Glu Glu  Glu Gly Gly 
    1655                 1660                 1665             


Gly Ala  Gly Thr Lys Ser Val  Pro Glu Asp Asp Gly  His Ala Leu 
    1670                 1675                 1680             


Leu Ala  Glu Arg Ile Glu Lys  Ser Leu Val Glu Pro  Lys Glu Asp 
    1685                 1690                 1695             


Glu Lys  Gly Asp Asp Val Asp  Asp Pro Glu Asn Gln  Asn Ser Ala 
    1700                 1705                 1710             


Leu Ala  Asp Thr Asp Ala Ser  Gly Gly Leu Thr Lys  Glu Ser Pro 
    1715                 1720                 1725             


Asp Thr  Asn Gly Pro Lys Gln  Lys Glu Lys Glu Asp  Ala Gln Glu 
    1730                 1735                 1740             


Val Glu  Leu Gln Glu Gly Lys  Val His Ser Glu Ser  Asp Lys Ala 
    1745                 1750                 1755             


Ile Thr  Pro Gln Ala Gln Glu  Glu Leu Gln Lys Gln  Glu Arg Glu 
    1760                 1765                 1770             


Ser Ala  Lys Ser Glu Leu Thr  Glu Ser 
    1775                 1780         


<210>  394
<211>  1434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP13__Homo_sapiens__NP_001257475

<400>  394

Met Tyr Glu Arg His Lys Arg Arg Tyr Ser Leu Cys Asp Ile Ser Lys 
1               5                   10                  15      


Val Asp Arg Thr Val Asp Val Val Leu Leu Lys Ile Asn Arg Glu Asn 
            20                  25                  30          


Trp Cys Thr Ile Glu Pro Cys Pro Asp Ala Ala Ser Leu Leu Ala Ser 
        35                  40                  45              


Lys Gln Ser Pro Glu Cys Glu Asn Phe Leu Asp Val Gly Leu Gly Arg 
    50                  55                  60                  


Glu Cys Thr Ser Lys Gln Gly Val Leu Lys Arg Glu Ser Gly Ser Asp 
65                  70                  75                  80  


Ser Asp Leu Phe His Ser Pro Ser Asp Asp Met Asp Ser Ile Ile Phe 
                85                  90                  95      


Pro Lys Pro Glu Glu Glu His Leu Ala Cys Asp Ile Thr Gly Ser Ser 
            100                 105                 110         


Ser Ser Thr Asp Asp Thr Ala Ser Leu Asp Arg His Ser Ser His Gly 
        115                 120                 125             


Ser Asp Val Ser Leu Ser Gln Ile Leu Lys Pro Asn Arg Ser Arg Asp 
    130                 135                 140                 


Arg Gln Ser Leu Asp Gly Phe Tyr Ser His Gly Met Gly Ala Glu Gly 
145                 150                 155                 160 


Arg Glu Ser Glu Ser Glu Pro Ala Asp Pro Gly Asp Val Glu Glu Glu 
                165                 170                 175     


Glu Met Asp Ser Ile Thr Glu Val Pro Ala Asn Cys Ser Val Leu Arg 
            180                 185                 190         


Ser Ser Met Arg Ser Leu Ser Pro Phe Arg Arg His Ser Trp Gly Pro 
        195                 200                 205             


Gly Lys Asn Ala Ala Ser Asp Ala Glu Met Asn His Arg Ser Phe Ser 
    210                 215                 220                 


Leu Glu Gly Leu Thr Gly Gly Ala Gly Val Gly Asn Lys Pro Ser Ser 
225                 230                 235                 240 


Ser Leu Glu Val Ser Ser Ala Asn Ala Glu Glu Leu Arg His Pro Phe 
                245                 250                 255     


Ser Gly Glu Glu Arg Val Asp Ser Leu Val Ser Leu Ser Glu Glu Asp 
            260                 265                 270         


Leu Glu Ser Asp Gln Arg Glu His Arg Met Phe Asp Gln Gln Ile Cys 
        275                 280                 285             


His Arg Ser Lys Gln Gln Gly Phe Asn Tyr Cys Thr Ser Ala Ile Ser 
    290                 295                 300                 


Ser Pro Leu Thr Lys Ser Ile Ser Leu Met Thr Ile Ser His Pro Gly 
305                 310                 315                 320 


Leu Asp Asn Ser Arg Pro Phe His Ser Thr Phe His Asn Thr Ser Ala 
                325                 330                 335     


Asn Leu Thr Glu Ser Ile Thr Glu Glu Asn Tyr Asn Phe Leu Pro His 
            340                 345                 350         


Ser Pro Ser Lys Lys Asp Ser Glu Trp Lys Ser Gly Thr Lys Val Ser 
        355                 360                 365             


Arg Thr Phe Ser Tyr Ile Lys Asn Lys Met Ser Ser Ser Lys Lys Ser 
    370                 375                 380                 


Lys Glu Lys Glu Lys Glu Lys Asp Lys Ile Lys Glu Lys Glu Lys Asp 
385                 390                 395                 400 


Ser Lys Asp Lys Glu Lys Asp Lys Lys Thr Val Asn Gly His Thr Phe 
                405                 410                 415     


Ser Ser Ile Pro Val Val Gly Pro Ile Ser Cys Ser Gln Cys Met Lys 
            420                 425                 430         


Pro Phe Thr Asn Lys Asp Ala Tyr Thr Cys Ala Asn Cys Ser Ala Phe 
        435                 440                 445             


Val His Lys Gly Cys Arg Glu Ser Leu Ala Ser Cys Ala Lys Val Lys 
    450                 455                 460                 


Met Lys Pro Lys Gly Ser Leu Gln Ala His Asp Thr Ser Ser Leu Pro 
465                 470                 475                 480 


Thr Val Ile Met Arg Asn Lys Pro Ser Gln Pro Lys Glu Arg Pro Arg 
                485                 490                 495     


Ser Ala Val Leu Leu Val Asp Glu Thr Ala Thr Thr Pro Ile Phe Ala 
            500                 505                 510         


Asn Arg Arg Ser Gln Gln Ser Val Ser Leu Ser Lys Ser Val Ser Ile 
        515                 520                 525             


Gln Asn Ile Thr Gly Val Gly Asn Asp Glu Asn Met Ser Asn Thr Trp 
    530                 535                 540                 


Lys Phe Leu Ser His Ser Thr Asp Ser Leu Asn Lys Ile Ser Lys Val 
545                 550                 555                 560 


Asn Glu Ser Thr Glu Ser Leu Thr Asp Glu Gly Val Gly Thr Asp Met 
                565                 570                 575     


Asn Glu Gly Gln Leu Leu Gly Asp Phe Glu Ile Glu Ser Lys Gln Leu 
            580                 585                 590         


Glu Ala Glu Ser Trp Ser Arg Ile Ile Asp Ser Lys Phe Leu Lys Gln 
        595                 600                 605             


Gln Lys Lys Asp Val Val Lys Arg Gln Glu Val Ile Tyr Glu Leu Met 
    610                 615                 620                 


Gln Thr Glu Phe His His Val Arg Thr Leu Lys Ile Met Ser Gly Val 
625                 630                 635                 640 


Tyr Ser Gln Gly Met Met Ala Asp Leu Leu Phe Glu Gln Gln Met Val 
                645                 650                 655     


Glu Lys Leu Phe Pro Cys Leu Asp Glu Leu Ile Ser Ile His Ser Gln 
            660                 665                 670         


Phe Phe Gln Arg Ile Leu Glu Arg Lys Lys Glu Ser Leu Val Asp Lys 
        675                 680                 685             


Ser Glu Lys Asn Phe Leu Ile Lys Arg Ile Gly Asp Val Leu Val Asn 
    690                 695                 700                 


Gln Phe Ser Gly Glu Asn Ala Glu Arg Leu Lys Lys Thr Tyr Gly Lys 
705                 710                 715                 720 


Phe Cys Gly Gln His Asn Gln Ser Val Asn Tyr Phe Lys Asp Leu Tyr 
                725                 730                 735     


Ala Lys Asp Lys Arg Phe Gln Ala Phe Val Lys Lys Lys Met Ser Ser 
            740                 745                 750         


Ser Val Val Arg Arg Leu Gly Ile Pro Glu Cys Ile Leu Leu Val Thr 
        755                 760                 765             


Gln Arg Ile Thr Lys Tyr Pro Val Leu Phe Gln Arg Ile Leu Gln Cys 
    770                 775                 780                 


Thr Lys Asp Asn Glu Val Glu Gln Glu Asp Leu Ala Gln Ser Leu Ser 
785                 790                 795                 800 


Leu Val Lys Asp Val Ile Gly Ala Val Asp Ser Lys Val Ala Ser Tyr 
                805                 810                 815     


Glu Lys Lys Val Arg Leu Asn Glu Ile Tyr Thr Lys Thr Asp Ser Lys 
            820                 825                 830         


Ser Ile Met Arg Met Lys Ser Gly Gln Met Phe Ala Lys Glu Asp Leu 
        835                 840                 845             


Lys Arg Lys Lys Leu Val Arg Asp Gly Ser Val Phe Leu Lys Asn Ala 
    850                 855                 860                 


Ala Gly Arg Leu Lys Glu Val Gln Ala Val Leu Leu Thr Asp Ile Leu 
865                 870                 875                 880 


Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ser Leu Asp 
                885                 890                 895     


Gln Lys Ser Thr Val Ile Ser Leu Lys Lys Leu Ile Val Arg Glu Val 
            900                 905                 910         


Ala His Glu Glu Lys Gly Leu Phe Leu Ile Ser Met Gly Met Thr Asp 
        915                 920                 925             


Pro Glu Met Val Glu Val His Ala Ser Ser Lys Glu Glu Arg Asn Ser 
    930                 935                 940                 


Trp Ile Gln Ile Ile Gln Asp Thr Ile Asn Thr Leu Asn Arg Asp Glu 
945                 950                 955                 960 


Asp Glu Gly Ile Pro Ser Glu Asn Glu Glu Glu Lys Lys Met Leu Asp 
                965                 970                 975     


Thr Arg Ala Arg Glu Leu Lys Glu Gln Leu His Gln Lys Asp Gln Lys 
            980                 985                 990         


Ile Leu Leu Leu Leu Glu Glu Lys  Glu Met Ile Phe Arg  Asp Met Ala 
        995                 1000                 1005             


Glu Cys  Ser Thr Pro Leu Pro  Glu Asp Cys Ser Pro  Thr His Ser 
    1010                 1015                 1020             


Pro Arg  Val Leu Phe Arg Ser  Asn Thr Glu Glu Ala  Leu Lys Gly 
    1025                 1030                 1035             


Gly Pro  Leu Met Lys Ser Ala  Ile Asn Glu Val Glu  Ile Leu Gln 
    1040                 1045                 1050             


Gly Leu  Val Ser Gly Asn Leu  Gly Gly Thr Leu Gly  Pro Thr Val 
    1055                 1060                 1065             


Ser Ser  Pro Ile Glu Gln Asp  Val Val Gly Pro Val  Ser Leu Pro 
    1070                 1075                 1080             


Arg Arg  Ala Glu Thr Phe Gly  Gly Phe Asp Ser His  Gln Met Asn 
    1085                 1090                 1095             


Ala Ser  Lys Gly Gly Glu Lys  Glu Glu Gly Asp Asp  Gly Gln Asp 
    1100                 1105                 1110             


Leu Arg  Arg Thr Glu Ser Asp  Ser Gly Leu Lys Lys  Gly Gly Asn 
    1115                 1120                 1125             


Ala Asn  Leu Val Phe Met Leu  Lys Arg Asn Ser Glu  Gln Val Val 
    1130                 1135                 1140             


Gln Ser  Val Val His Leu Tyr  Glu Leu Leu Ser Ala  Leu Gln Gly 
    1145                 1150                 1155             


Val Val  Leu Gln Gln Asp Ser  Tyr Ile Glu Asp Gln  Lys Leu Val 
    1160                 1165                 1170             


Leu Ser  Glu Arg Ala Leu Thr  Arg Ser Leu Ser Arg  Pro Ser Ser 
    1175                 1180                 1185             


Leu Ile  Glu Gln Glu Lys Gln  Arg Ser Leu Glu Lys  Gln Arg Gln 
    1190                 1195                 1200             


Asp Leu  Ala Asn Leu Gln Lys  Gln Gln Ala Gln Tyr  Leu Glu Glu 
    1205                 1210                 1215             


Lys Arg  Arg Arg Glu Arg Glu  Trp Glu Ala Arg Glu  Arg Glu Leu 
    1220                 1225                 1230             


Arg Glu  Arg Glu Ala Leu Leu  Ala Gln Arg Glu Glu  Glu Val Gln 
    1235                 1240                 1245             


Gln Gly  Gln Gln Asp Leu Glu  Lys Glu Arg Glu Glu  Leu Gln Gln 
    1250                 1255                 1260             


Lys Lys  Gly Thr Tyr Gln Tyr  Asp Leu Glu Arg Leu  Arg Ala Ala 
    1265                 1270                 1275             


Gln Lys  Gln Leu Glu Arg Glu  Gln Glu Gln Leu Arg  Arg Glu Ala 
    1280                 1285                 1290             


Glu Arg  Leu Ser Gln Arg Gln  Thr Glu Arg Asp Leu  Cys Gln Val 
    1295                 1300                 1305             


Ser His  Pro His Thr Lys Leu  Met Arg Ile Pro Ser  Phe Phe Pro 
    1310                 1315                 1320             


Ser Pro  Glu Glu Pro Pro Ser  Pro Ser Ala Pro Ser  Ile Ala Lys 
    1325                 1330                 1335             


Ser Gly  Ser Leu Asp Ser Glu  Leu Ser Val Ser Pro  Lys Arg Asn 
    1340                 1345                 1350             


Ser Ile  Ser Arg Thr His Lys  Asp Lys Gly Pro Phe  His Ile Leu 
    1355                 1360                 1365             


Ser Ser  Thr Ser Gln Thr Asn  Lys Gly Pro Glu Gly  Gln Ser Gln 
    1370                 1375                 1380             


Ala Pro  Ala Ser Thr Ser Ala  Ser Thr Arg Leu Phe  Gly Leu Thr 
    1385                 1390                 1395             


Lys Pro  Lys Glu Lys Lys Glu  Lys Lys Lys Lys Asn  Lys Thr Ser 
    1400                 1405                 1410             


Arg Ser  Gln Pro Gly Asp Gly  Pro Ala Ser Glu Val  Ser Ala Glu 
    1415                 1420                 1425             


Gly Glu  Glu Ile Phe Cys 
    1430                 


<210>  395
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP17A__Homo_sapiens__NP_005079

<400>  395

Met Ala Ala Ala Thr Ile Val His Asp Thr Ser Glu Ala Val Glu Leu 
1               5                   10                  15      


Cys Pro Ala Tyr Gly Leu Tyr Leu Lys Pro Ile Thr Lys Met Thr Ile 
            20                  25                  30          


Ser Val Ala Leu Pro Gln Leu Lys Gln Pro Gly Lys Ser Ile Ser Asn 
        35                  40                  45              


Trp Glu Val Met Glu Arg Leu Lys Gly Met Val Gln Asn His Gln Phe 
    50                  55                  60                  


Ser Thr Leu Arg Ile Ser Lys Ser Thr Met Asp Phe Ile Arg Phe Glu 
65                  70                  75                  80  


Gly Glu Val Glu Asn Lys Ser Leu Val Lys Ser Phe Leu Ala Cys Leu 
                85                  90                  95      


Asp Gly Lys Thr Ile Lys Leu Ser Gly Phe Ser Asp Ile Leu Lys Val 
            100                 105                 110         


Arg Ala Ala Glu Phe Lys Ile Asp Phe Pro Thr Arg His Asp Trp Asp 
        115                 120                 125             


Ser Phe Phe Arg Asp Ala Lys Asp Met Asn Glu Thr Leu Pro Gly Glu 
    130                 135                 140                 


Arg Pro Asp Thr Ile His Leu Glu Gly Leu Pro Cys Lys Trp Phe Ala 
145                 150                 155                 160 


Leu Lys Glu Ser Gly Ser Glu Lys Pro Ser Glu Asp Val Leu Val Lys 
                165                 170                 175     


Val Phe Glu Lys Phe Gly Glu Ile Arg Asn Val Asp Ile Pro Met Leu 
            180                 185                 190         


Asp Pro Tyr Arg Glu Glu Met Thr Gly Arg Asn Phe His Thr Phe Ser 
        195                 200                 205             


Phe Gly Gly His Leu Asn Phe Glu Ala Tyr Val Gln Tyr Arg Glu Tyr 
    210                 215                 220                 


Met Gly Phe Ile Gln Ala Met Ser Ala Leu Arg Gly Met Lys Leu Met 
225                 230                 235                 240 


Tyr Lys Gly Glu Asp Gly Lys Ala Val Ala Cys Asn Ile Lys Val Ser 
                245                 250                 255     


Phe Asp Ser Thr Lys His Leu Ser Asp Ala Ser Ile Lys Lys Arg Gln 
            260                 265                 270         


Leu Glu Arg Gln Lys Leu Gln Glu Leu Glu Gln Gln Arg Glu Glu Gln 
        275                 280                 285             


Lys Arg Arg Glu Lys Glu Ala Glu Glu Arg Gln Arg Ala Glu Glu Arg 
    290                 295                 300                 


Lys Gln Lys Glu Leu Glu Glu Leu Glu Arg Glu Arg Lys Arg Glu Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Glu Gln Lys Gln Arg Asp Arg Glu Leu Arg Arg 
                325                 330                 335     


Asn Gln Lys Lys Leu Glu Lys Leu Gln Ala Glu Glu Gln Lys Gln Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Leu Glu Glu Arg Lys Leu Leu Leu Ala Gln Arg 
        355                 360                 365             


Asn Leu Gln Ser Ile Arg Leu Ile Ala Glu Leu Leu Ser Arg Ala Lys 
    370                 375                 380                 


Ala Val Lys Leu Arg Glu Gln Glu Gln Lys Glu Glu Lys Leu Arg Leu 
385                 390                 395                 400 


Gln Gln Gln Glu Glu Arg Arg Arg Leu Gln Glu Ala Glu Leu Arg Arg 
                405                 410                 415     


Val Glu Glu Glu Lys Glu Arg Ala Leu Gly Leu Gln Arg Lys Glu Arg 
            420                 425                 430         


Glu Leu Arg Glu Arg Leu Leu Ser Ile Leu Leu Ser Lys Lys Pro Asp 
        435                 440                 445             


Asp Ser His Thr His Asp Glu Leu Gly Val Ala His Ala Asp Leu Leu 
    450                 455                 460                 


Gln Pro Val Leu Asp Ile Leu Gln Thr Val Ser Ser Gly Cys Val Ser 
465                 470                 475                 480 


Ala Thr Thr Leu His Pro Leu Gly Gly Gln Pro Pro Ala Gly Ala Pro 
                485                 490                 495     


Lys Glu Ser Pro Ala His Pro Glu Ala Asp Gly Ala Pro Lys Ser Val 
            500                 505                 510         


Asn Gly Ser Val Ala Glu Glu Ala Pro Cys Lys Glu Val Gln Ser Ser 
        515                 520                 525             


Cys Arg Val Val Pro Glu Asp Gly Ser Pro Glu Lys Arg Cys Pro Gly 
    530                 535                 540                 


Gly Val Leu Ser Cys Ile Pro Asp Asn Asn Gln Gln Pro Lys Gly Ile 
545                 550                 555                 560 


Pro Ala Cys Glu Gln Asn Val Ser Arg Lys Asp Thr Arg Ser Glu Gln 
                565                 570                 575     


Asp Lys Cys Asn Arg Glu Pro Ser Lys Gly Arg Gly Arg Ala Thr Gly 
            580                 585                 590         


Asp Gly Leu Ala Asp Arg His Lys Arg Glu Arg Ser Arg Ala Arg Arg 
        595                 600                 605             


Ala Ser Ser Arg Glu Asp Gly Arg Pro Arg Lys Glu Arg Arg Pro His 
    610                 615                 620                 


Lys Lys His Ala Tyr Lys Asp Asp Ser Pro Arg Arg Arg Ser Thr Ser 
625                 630                 635                 640 


Pro Asp His Thr Arg Ser Arg Arg Ser His Ser Lys Asp Arg His Arg 
                645                 650                 655     


Arg Glu Arg Ser Arg Glu Arg Arg Gly Ser Ala Ser Arg Lys His Ser 
            660                 665                 670         


Arg His Arg Arg Arg Ser Glu Arg Ser Arg Ser Arg Ser Pro Ser Arg 
        675                 680                 685             


His Arg Ser Thr Trp Asn Arg 
    690                 695 


<210>  396
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP1__Homo_sapiens__NP_003479

<400>  396

Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Thr Pro Pro Ser Val Thr Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Thr Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Thr His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Thr Thr Asp Met Arg Leu Arg Pro Gly Thr Arg Arg Asp Asp Ser 
        115                 120                 125             


Thr Lys Leu Glu Leu Ala Leu Thr Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro Val Val Pro Ala Glu Lys Arg Ser Ser 
            180                 185                 190         


Gly Glu Arg Ala Arg Glu Thr Gly Gly Ala Glu Gly Thr Gly Asp Ala 
        195                 200                 205             


Val Leu Gly Glu Lys Val Leu Glu Glu Ala Leu Leu Ser Arg Glu His 
    210                 215                 220                 


Val Leu Glu Leu Glu Asn Ser Lys Gly Pro Ser Leu Ala Ser Leu Glu 
225                 230                 235                 240 


Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser Ser Gln Val Val Gly Pro 
                245                 250                 255     


Val Gln Glu Glu Glu Tyr Val Ala Glu Lys Leu Pro Ser Arg Phe Ile 
            260                 265                 270         


Glu Ser Ala His Thr Glu Leu Ala Lys Asp Asp Ala Ala Pro Ala Pro 
        275                 280                 285             


Pro Val Ala Asp Ala Lys Ala Gln Asp Arg Gly Val Glu Gly Glu Leu 
    290                 295                 300                 


Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu Gly Leu Asp Arg Asn 
305                 310                 315                 320 


Glu Glu Gly Leu Asp Arg Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu 
                325                 330                 335     


Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln Ile Ile 
            340                 345                 350         


Ser Gln Val Ile Ser Glu Ala Thr Glu Gln Val Leu Ala Thr Thr Val 
        355                 360                 365             


Gly Lys Val Ala Gly Arg Val Cys Gln Ala Ser Gln Leu Gln Gly Gln 
    370                 375                 380                 


Lys Glu Glu Ser Cys Val Pro Val His Gln Lys Thr Val Leu Gly Pro 
385                 390                 395                 400 


Asp Thr Ala Glu Pro Ala Thr Ala Glu Ala Ala Val Ala Pro Pro Asp 
                405                 410                 415     


Ala Gly Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro 
            420                 425                 430         


Lys Thr Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Thr Lys 
        435                 440                 445             


Asp Ser Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys 
    450                 455                 460                 


Leu Ala Leu Thr Thr Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile 
465                 470                 475                 480 


Leu Val Glu Asp Ala Thr Cys Val Thr Cys Met Ser Asp Ser Ser Gln 
                485                 490                 495     


Ser Val Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser 
            500                 505                 510         


Thr Ser Gly Leu Glu Asp Ser Cys Thr Glu Thr Ser Ser Ser Pro Arg 
        515                 520                 525             


Asp Lys Ala Ile Thr Pro Pro Leu Pro Glu Ser Thr Val Pro Phe Ser 
    530                 535                 540                 


Asn Gly Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly 
545                 550                 555                 560 


Trp Thr Met Asp Ala Glu Ala Asp His Ser Gly Gly Ser Asp Arg Asn 
                565                 570                 575     


Ser Met Asp Ser Val Asp Ser Cys Cys Ser Leu Lys Lys Thr Glu Ser 
            580                 585                 590         


Phe Gln Asn Ala Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile 
        595                 600                 605             


Ile Trp Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly 
    610                 615                 620                 


Lys Gln Gly Arg Tyr Val Ser Phe Leu Lys Gln Thr Ser Gly Ala Lys 
625                 630                 635                 640 


Ile Tyr Ile Ser Thr Leu Pro Tyr Thr Gln Ser Val Gln Ile Cys His 
                645                 650                 655     


Ile Glu Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly 
            660                 665                 670         


Lys Lys Phe Lys Glu Leu Asn Leu Thr Asn Ile Tyr Ala Pro Pro Leu 
        675                 680                 685             


Pro Ser Leu Ala Leu Pro Ser Leu Pro Met Thr Ser Trp Leu Met Leu 
    690                 695                 700                 


Pro Asp Gly Ile Thr Val Glu Val Ile Val Val Asn Gln Val Asn Ala 
705                 710                 715                 720 


Gly His Leu Phe Val Gln Gln His Thr His Pro Thr Phe His Ala Leu 
                725                 730                 735     


Arg Ser Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile 
            740                 745                 750         


Pro Thr Leu Pro Thr Pro Val Glu Ile Thr Val Ile Cys Ala Ala Pro 
        755                 760                 765             


Gly Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr Glu 
    770                 775                 780                 


Glu Thr Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr Lys 
785                 790                 795                 800 


Arg Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val Thr 
                805                 810                 815     


Leu Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Met Pro Leu 
            820                 825                 830         


Ser Asp Asp Asp Gln Phe Ser Pro Glu Ala Asp Ala Ala Met Ser Glu 
        835                 840                 845             


Met Thr Gly Asn Thr Ala Leu Leu Ala Gln Val Thr Ser Tyr Ser Pro 
    850                 855                 860                 


Thr Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu Val 
865                 870                 875                 880 


Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val 
                885                 890                 895     


Asp Ser Tyr Tyr Thr Ser Leu 
            900             


<210>  397
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP2__Homo_sapiens__NP_001004065

<400>  397

Met Arg Trp Pro Gln Pro Gly Ala Ala Ala Arg Leu Pro Pro Glu Ser 
1               5                   10                  15      


Pro Gly Pro Pro Glu Ser Pro Gly Pro Pro Glu Arg Glu Ala Ala Ala 
            20                  25                  30          


Ala Arg Arg Trp Thr Gly Ala Glu Pro Gln Asp Cys Ala Pro Gly Ser 
        35                  40                  45              


Gly Arg Pro Glu Lys Pro Pro Gln Leu Ser Glu Asp Asp Ile Trp Leu 
    50                  55                  60                  


Lys Ser Glu Gly Asp Asn Tyr Ser Ala Thr Leu Leu Glu Pro Ala Ala 
65                  70                  75                  80  


Ser Ser Leu Ser Pro Asp His Lys Asn Met Glu Ile Glu Val Ser Val 
                85                  90                  95      


Ala Glu Cys Lys Ser Val Pro Gly Ile Thr Ser Thr Pro His Pro Met 
            100                 105                 110         


Asp His Pro Ser Ala Phe Tyr Ser Pro Pro His Asn Gly Leu Leu Thr 
        115                 120                 125             


Asp His His Glu Ser Leu Asp Asn Asp Val Ala Arg Glu Ile Arg Tyr 
    130                 135                 140                 


Leu Asp Glu Val Leu Glu Ala Asn Cys Cys Asp Ser Ala Val Asp Gly 
145                 150                 155                 160 


Thr Tyr Asn Gly Thr Ser Ser Pro Glu Pro Gly Ala Val Val Leu Val 
                165                 170                 175     


Gly Gly Leu Ser Pro Pro Val His Glu Ala Thr Gln Pro Glu Pro Thr 
            180                 185                 190         


Glu Arg Thr Ala Ser Arg Gln Ala Pro Pro His Ile Glu Leu Ser Asn 
        195                 200                 205             


Ser Ser Pro Asp Pro Met Ala Glu Ala Glu Arg Thr Asn Gly His Ser 
    210                 215                 220                 


Pro Ser Gln Pro Arg Asp Ala Leu Gly Asp Ser Leu Gln Val Pro Val 
225                 230                 235                 240 


Ser Pro Ser Ser Thr Thr Ser Ser Arg Cys Ser Ser Arg Asp Gly Glu 
                245                 250                 255     


Phe Thr Leu Thr Thr Leu Lys Lys Glu Ala Lys Phe Glu Leu Arg Ala 
            260                 265                 270         


Phe His Glu Asp Lys Lys Pro Ser Lys Leu Phe Glu Asp Asp Glu His 
        275                 280                 285             


Glu Lys Glu Gln Tyr Cys Ile Arg Lys Val Arg Pro Ser Glu Glu Met 
    290                 295                 300                 


Leu Glu Leu Glu Lys Glu Arg Arg Glu Leu Ile Arg Ser Gln Ala Val 
305                 310                 315                 320 


Lys Lys Asn Pro Gly Ile Ala Ala Lys Trp Trp Asn Pro Pro Gln Glu 
                325                 330                 335     


Lys Thr Ile Glu Glu Gln Leu Asp Glu Glu His Leu Glu Ser His Lys 
            340                 345                 350         


Lys Tyr Lys Glu Arg Lys Glu Arg Arg Ala Gln Gln Glu Gln Leu Leu 
        355                 360                 365             


Leu Gln Lys Gln Leu Gln Gln Gln Gln Gln Gln Pro Pro Ser Gln Leu 
    370                 375                 380                 


Cys Thr Ala Pro Ala Ser Ser His Glu Arg Ala Ser Met Ile Asp Lys 
385                 390                 395                 400 


Ala Lys Glu Asp Ile Val Thr Glu Gln Ile Asp Phe Ser Ala Ala Arg 
                405                 410                 415     


Lys Gln Phe Gln Leu Met Glu Asn Ser Arg Gln Ala Val Ala Lys Gly 
            420                 425                 430         


Gln Ser Thr Pro Arg Leu Phe Ser Ile Lys Pro Phe Tyr Arg Pro Leu 
        435                 440                 445             


Gly Ser Val Asn Ser Asp Lys Pro Leu Thr Asn Pro Arg Pro Pro Ser 
    450                 455                 460                 


Val Gly Gly Pro Pro Glu Asp Ser Gly Ala Ser Ala Ala Lys Gly Gln 
465                 470                 475                 480 


Lys Ser Pro Gly Ala Leu Glu Thr Pro Ser Ala Ala Gly Ser Gln Gly 
                485                 490                 495     


Asn Thr Ala Ser Gln Gly Lys Glu Gly Pro Tyr Ser Glu Pro Ser Lys 
            500                 505                 510         


Arg Gly Pro Leu Ser Lys Leu Trp Ala Glu Asp Gly Glu Phe Thr Ser 
        515                 520                 525             


Ala Arg Ala Val Leu Thr Val Val Lys Asp Asp Asp His Gly Ile Leu 
    530                 535                 540                 


Asp Gln Phe Ser Arg Ser Val Asn Val Ser Leu Thr Gln Glu Glu Leu 
545                 550                 555                 560 


Asp Ser Gly Leu Asp Glu Leu Ser Val Arg Ser Gln Asp Thr Thr Val 
                565                 570                 575     


Leu Glu Thr Leu Ser Asn Asp Phe Ser Met Asp Asn Ile Ser Asp Ser 
            580                 585                 590         


Gly Ala Ser Asn Glu Thr Thr Asn Ala Leu Gln Glu Asn Ser Leu Ala 
        595                 600                 605             


Asp Phe Ser Leu Pro Gln Thr Pro Gln Thr Asp Asn Pro Ser Glu Gly 
    610                 615                 620                 


Arg Gly Glu Gly Val Ser Lys Ser Phe Ser Asp His Gly Phe Tyr Ser 
625                 630                 635                 640 


Pro Ser Ser Thr Leu Gly Asp Ser Pro Leu Val Asp Asp Pro Leu Glu 
                645                 650                 655     


Tyr Gln Ala Gly Leu Leu Val Gln Asn Ala Ile Gln Gln Ala Ile Ala 
            660                 665                 670         


Glu Gln Val Asp Lys Ala Val Ser Lys Thr Ser Arg Asp Gly Ala Glu 
        675                 680                 685             


Gln Gln Gly Pro Glu Ala Thr Val Glu Glu Ala Glu Ala Ala Ala Phe 
    690                 695                 700                 


Gly Ser Glu Lys Pro Gln Ser Met Phe Glu Pro Pro Gln Val Ser Ser 
705                 710                 715                 720 


Pro Val Gln Glu Lys Arg Asp Val Leu Pro Lys Ile Leu Pro Ala Glu 
                725                 730                 735     


Asp Arg Ala Leu Arg Glu Arg Gly Pro Pro Gln Pro Leu Pro Ala Val 
            740                 745                 750         


Gln Pro Ser Gly Pro Ile Asn Met Glu Glu Thr Arg Pro Glu Gly Ser 
        755                 760                 765             


Tyr Phe Ser Lys Tyr Ser Glu Ala Ala Glu Leu Arg Ser Thr Ala Ser 
    770                 775                 780                 


Leu Leu Ala Thr Gln Glu Ser Asp Val Met Val Gly Pro Phe Lys Leu 
785                 790                 795                 800 


Arg Ser Arg Lys Gln Arg Thr Leu Ser Met Ile Glu Glu Glu Ile Arg 
                805                 810                 815     


Ala Ala Gln Glu Arg Glu Glu Glu Leu Lys Arg Gln Arg Gln Val Leu 
            820                 825                 830         


Gln Ser Thr Gln Ser Pro Arg Thr Lys Asn Ala Pro Ser Leu Pro Ser 
        835                 840                 845             


Arg Thr Cys Tyr Lys Thr Ala Pro Gly Lys Ile Glu Lys Val Lys Pro 
    850                 855                 860                 


Pro Pro Ser Pro Thr Thr Glu Gly Pro Ser Leu Gln Pro Asp Leu Ala 
865                 870                 875                 880 


Pro Glu Glu Ala Ala Gly Thr Gln Arg Pro Lys Asn Leu Met Gln Thr 
                885                 890                 895     


Leu Met Glu Asp Tyr Glu Thr His Lys Ser Lys Arg Arg Glu Arg Met 
            900                 905                 910         


Asp Asp Ser Ser Val Leu Glu Ala Thr Arg Val Asn Arg Arg Lys Ser 
        915                 920                 925             


Ala Leu Ala Leu Arg Trp Glu Ala Gly Ile Tyr Ala Asn Gln Glu Glu 
    930                 935                 940                 


Glu Asp Asn Glu 
945             


<210>  398
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP3__Homo_sapiens__NP_001265238

<400>  398

Met Ser Glu Lys Val Asp Trp Leu Gln Ser Gln Asn Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Val Tyr Ser Pro Gly Asp Asn Gln Ala Gln Asp Trp Lys Met 
            20                  25                  30          


Asp Thr Ser Thr Asp Pro Val Arg Val Leu Ser Trp Leu Arg Arg Asp 
        35                  40                  45              


Leu Glu Lys Ser Thr Ala Glu Phe Gln Asp Val Arg Phe Lys Pro Gly 
    50                  55                  60                  


Glu Ser Phe Gly Gly Glu Thr Ser Asn Ser Gly Asp Pro His Lys Gly 
65                  70                  75                  80  


Phe Ser Val Asp Tyr Tyr Asn Thr Thr Thr Lys Gly Thr Pro Glu Arg 
                85                  90                  95      


Leu His Phe Glu Met Thr His Lys Glu Ile Pro Cys Gln Gly Pro Arg 
            100                 105                 110         


Ala Gln Leu Gly Asn Gly Ser Ser Val Asp Glu Val Ser Phe Tyr Ala 
        115                 120                 125             


Asn Arg Leu Thr Asn Leu Val Ile Ala Met Ala Arg Lys Glu Ile Asn 
    130                 135                 140                 


Glu Lys Ile Asp Gly Ser Glu Asn Lys Cys Val Tyr Gln Ser Leu Tyr 
145                 150                 155                 160 


Met Gly Asn Glu Pro Thr Pro Thr Lys Ser Leu Ser Lys Ile Ala Ser 
                165                 170                 175     


Glu Leu Val Asn Glu Thr Val Ser Ala Cys Ser Arg Asn Ala Ala Pro 
            180                 185                 190         


Asp Lys Ala Pro Gly Ser Gly Asp Arg Val Ser Gly Ser Ser Gln Ser 
        195                 200                 205             


Pro Pro Asn Leu Lys Tyr Lys Ser Thr Leu Lys Ile Lys Glu Ser Thr 
    210                 215                 220                 


Lys Glu Arg Gln Gly Pro Asp Asp Lys Pro Pro Ser Lys Lys Ser Phe 
225                 230                 235                 240 


Phe Tyr Lys Glu Val Phe Glu Ser Arg Asn Gly Asp Tyr Ala Arg Glu 
                245                 250                 255     


Gly Gly Arg Phe Phe Pro Arg Glu Arg Lys Arg Phe Arg Gly Gln Glu 
            260                 265                 270         


Arg Pro Asp Asp Phe Thr Ala Ser Val Ser Glu Gly Ile Met Thr Tyr 
        275                 280                 285             


Ala Asn Ser Val Val Ser Asp Met Met Val Ser Ile Met Lys Thr Leu 
    290                 295                 300                 


Lys Ile Gln Val Lys Asp Thr Thr Ile Ala Thr Ile Leu Leu Lys Lys 
305                 310                 315                 320 


Val Leu Leu Lys His Ala Lys Glu Val Val Ser Asp Leu Ile Asp Ser 
                325                 330                 335     


Phe Leu Arg Asn Leu His Ser Val Thr Gly Thr Leu Met Thr Asp Thr 
            340                 345                 350         


Gln Phe Val Ser Ala Val Lys Arg Thr Val Phe Ser His Gly Ser Gln 
        355                 360                 365             


Lys Ala Thr Asp Ile Met Asp Ala Met Leu Arg Lys Leu Tyr Asn Val 
    370                 375                 380                 


Met Phe Ala Lys Lys Val Pro Glu His Val Arg Lys Ala Gln Asp Lys 
385                 390                 395                 400 


Ala Glu Ser Tyr Ser Leu Ile Ser Met Lys Gly Met Gly Asp Pro Lys 
                405                 410                 415     


Asn Arg Asn Val Asn Phe Ala Met Lys Ser Glu Thr Lys Leu Arg Glu 
            420                 425                 430         


Lys Met Tyr Ser Glu Pro Lys Ser Glu Glu Glu Thr Cys Ala Lys Thr 
        435                 440                 445             


Leu Gly Glu His Ile Ile Lys Glu Gly Leu Thr Leu Trp His Lys Ser 
    450                 455                 460                 


Gln Gln Lys Glu Cys Lys Ser Leu Gly Phe Gln His Ala Ala Phe Glu 
465                 470                 475                 480 


Ala Pro Asn Thr Gln Arg Lys Pro Ala Ser Asp Ile Ser Phe Glu Tyr 
                485                 490                 495     


Pro Glu Asp Ile Gly Asn Leu Ser Leu Pro Pro Tyr Pro Pro Glu Lys 
            500                 505                 510         


Pro Glu Asn Phe Met Tyr Asp Ser Asp Ser Trp Ala Lys Asp Leu Ile 
        515                 520                 525             


Val Ser Ala Leu Leu Leu Ile Gln Tyr His Leu Ala Gln Gly Gly Arg 
    530                 535                 540                 


Arg Asp Ala Arg Ser Phe Val Glu Ala Ala Gly Thr Thr Asn Phe Pro 
545                 550                 555                 560 


Ala Asn Glu Pro Pro Val Ala Pro Asp Glu Ser Cys Leu Lys Ser Ala 
                565                 570                 575     


Pro Ile Val Gly Asp Gln Glu Gln Ala Glu Lys Lys Asp Leu Arg Ser 
            580                 585                 590         


Val Phe Phe Asn Phe Ile Arg Asn Leu Leu Ser Glu Thr Ile Phe Lys 
        595                 600                 605             


Arg Asp Gln Ser Pro Glu Pro Lys Val Pro Glu Gln Pro Val Lys Glu 
    610                 615                 620                 


Asp Arg Lys Leu Cys Glu Arg Pro Leu Ala Ser Ser Pro Pro Arg Leu 
625                 630                 635                 640 


Tyr Glu Asp Asp Glu Thr Pro Gly Ala Leu Ser Gly Leu Thr Lys Met 
                645                 650                 655     


Ala Val Ser Gln Ile Asp Gly His Met Ser Gly Gln Met Val Glu His 
            660                 665                 670         


Leu Met Asn Ser Val Met Lys Leu Cys Val Ile Ile Ala Lys Ser Cys 
        675                 680                 685             


Asp Ala Ser Leu Ala Glu Leu Gly Asp Asp Lys Ser Gly Asp Ala Ser 
    690                 695                 700                 


Arg Leu Thr Ser Ala Phe Pro Asp Ser Leu Tyr Glu Cys Leu Pro Ala 
705                 710                 715                 720 


Lys Gly Thr Gly Ser Ala Glu Ala Val Leu Gln Asn Ala Tyr Gln Ala 
                725                 730                 735     


Ile His Asn Glu Met Arg Gly Thr Ser Gly Gln Pro Pro Glu Gly Cys 
            740                 745                 750         


Ala Ala Pro Thr Val Ile Val Ser Asn His Asn Leu Thr Asp Thr Val 
        755                 760                 765             


Gln Asn Lys Gln Leu Gln Ala Val Leu Gln Trp Val Ala Ala Ser Glu 
    770                 775                 780                 


Leu Asn Val Pro Ile Leu Tyr Phe Ala Gly Asp Asp Glu Gly Ile Gln 
785                 790                 795                 800 


Glu Lys Leu Leu Gln Leu Ser Ala Ala Ala Val Asp Lys Gly Cys Ser 
                805                 810                 815     


Val Gly Glu Val Leu Gln Ser Val Leu Arg Tyr Glu Lys Glu Arg Gln 
            820                 825                 830         


Leu Asn Glu Ala Val Gly Asn Val Thr Pro Leu Gln Leu Leu Asp Trp 
        835                 840                 845             


Leu Met Val Asn Leu 
    850             


<210>  399
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP4__Homo_sapiens__NP_003877

<400>  399

Met Met Ala Tyr Ser Asp Thr Thr Met Met Ser Asp Asp Ile Asp Trp 
1               5                   10                  15      


Leu Arg Ser His Arg Gly Val Cys Lys Val Asp Leu Tyr Asn Pro Glu 
            20                  25                  30          


Gly Gln Gln Asp Gln Asp Arg Lys Val Ile Cys Phe Val Asp Val Ser 
        35                  40                  45              


Thr Leu Asn Val Glu Asp Lys Asp Tyr Lys Asp Ala Ala Ser Ser Ser 
    50                  55                  60                  


Ser Glu Gly Asn Leu Asn Leu Gly Ser Leu Glu Glu Lys Glu Ile Ile 
65                  70                  75                  80  


Val Ile Lys Asp Thr Glu Lys Lys Asp Gln Ser Lys Thr Glu Gly Ser 
                85                  90                  95      


Val Cys Leu Phe Lys Gln Ala Pro Ser Asp Pro Val Ser Val Leu Asn 
            100                 105                 110         


Trp Leu Leu Ser Asp Leu Gln Lys Tyr Ala Leu Gly Phe Gln His Ala 
        115                 120                 125             


Leu Ser Pro Ser Thr Ser Thr Cys Lys His Lys Val Gly Asp Thr Glu 
    130                 135                 140                 


Gly Glu Tyr His Arg Ala Ser Ser Glu Asn Cys Tyr Ser Val Tyr Ala 
145                 150                 155                 160 


Asp Gln Val Asn Ile Asp Tyr Leu Met Asn Arg Pro Gln Asn Leu Arg 
                165                 170                 175     


Leu Glu Met Thr Ala Ala Lys Asn Thr Asn Asn Asn Gln Ser Pro Ser 
            180                 185                 190         


Ala Pro Pro Ala Lys Pro Pro Ser Thr Gln Arg Ala Val Ile Ser Pro 
        195                 200                 205             


Asp Gly Glu Cys Ser Ile Asp Asp Leu Ser Phe Tyr Val Asn Arg Leu 
    210                 215                 220                 


Ser Ser Leu Val Ile Gln Met Ala His Lys Glu Ile Lys Glu Lys Leu 
225                 230                 235                 240 


Glu Gly Lys Ser Lys Cys Leu His His Ser Ile Cys Pro Ser Pro Gly 
                245                 250                 255     


Asn Lys Glu Arg Ile Ser Pro Arg Thr Pro Ala Ser Lys Ile Ala Ser 
            260                 265                 270         


Glu Met Ala Tyr Glu Ala Val Glu Leu Thr Ala Ala Glu Met Arg Gly 
        275                 280                 285             


Thr Gly Glu Glu Ser Arg Glu Gly Gly Gln Lys Ser Phe Leu Tyr Ser 
    290                 295                 300                 


Glu Leu Ser Asn Lys Ser Lys Ser Gly Asp Lys Gln Met Ser Gln Arg 
305                 310                 315                 320 


Glu Ser Lys Glu Phe Ala Asp Ser Ile Ser Lys Gly Leu Met Val Tyr 
                325                 330                 335     


Ala Asn Gln Val Ala Ser Asp Met Met Val Ser Leu Met Lys Thr Leu 
            340                 345                 350         


Lys Val His Ser Ser Gly Lys Pro Ile Pro Ala Ser Val Val Leu Lys 
        355                 360                 365             


Arg Val Leu Leu Arg His Thr Lys Glu Ile Val Ser Asp Leu Ile Asp 
    370                 375                 380                 


Ser Cys Met Lys Asn Leu His Asn Ile Thr Gly Val Leu Met Thr Asp 
385                 390                 395                 400 


Ser Asp Phe Val Ser Ala Val Lys Arg Asn Leu Phe Asn Gln Trp Lys 
                405                 410                 415     


Gln Asn Ala Thr Asp Ile Met Glu Ala Met Leu Lys Arg Leu Val Ser 
            420                 425                 430         


Ala Leu Ile Gly Glu Glu Lys Glu Thr Lys Ser Gln Ser Leu Ser Tyr 
        435                 440                 445             


Ala Ser Leu Lys Ala Gly Ser His Asp Pro Lys Cys Arg Asn Gln Ser 
    450                 455                 460                 


Leu Glu Phe Ser Thr Met Lys Ala Glu Met Lys Glu Arg Asp Lys Gly 
465                 470                 475                 480 


Lys Met Lys Ser Asp Pro Cys Lys Ser Leu Thr Ser Ala Glu Lys Val 
                485                 490                 495     


Gly Glu His Ile Leu Lys Glu Gly Leu Thr Ile Trp Asn Gln Lys Gln 
            500                 505                 510         


Gly Asn Ser Cys Lys Val Ala Thr Lys Ala Cys Ser Asn Lys Asp Glu 
        515                 520                 525             


Lys Gly Glu Lys Ile Asn Ala Ser Thr Asp Ser Leu Ala Lys Asp Leu 
    530                 535                 540                 


Ile Val Ser Ala Leu Lys Leu Ile Gln Tyr His Leu Thr Gln Gln Thr 
545                 550                 555                 560 


Lys Gly Lys Asp Thr Cys Glu Glu Asp Cys Pro Gly Ser Thr Met Gly 
                565                 570                 575     


Tyr Met Ala Gln Ser Thr Gln Tyr Glu Lys Cys Gly Gly Gly Gln Ser 
            580                 585                 590         


Ala Lys Ala Leu Ser Val Lys Gln Leu Glu Ser His Arg Ala Pro Gly 
        595                 600                 605             


Pro Ser Thr Cys Gln Lys Glu Asn Gln His Leu Asp Ser Gln Lys Met 
    610                 615                 620                 


Asp Met Ser Asn Ile Val Leu Met Leu Ile Gln Lys Leu Leu Asn Glu 
625                 630                 635                 640 


Asn Pro Phe Lys Cys Glu Asp Pro Cys Glu Gly Glu Asn Lys Cys Ser 
                645                 650                 655     


Glu Pro Arg Ala Ser Lys Ala Ala Ser Met Ser Asn Arg Ser Asp Lys 
            660                 665                 670         


Ala Glu Glu Gln Cys Gln Glu His Gln Glu Leu Asp Cys Thr Ser Gly 
        675                 680                 685             


Met Lys Gln Ala Asn Gly Gln Phe Ile Asp Lys Leu Val Glu Ser Val 
    690                 695                 700                 


Met Lys Leu Cys Leu Ile Met Ala Lys Tyr Ser Asn Asp Gly Ala Ala 
705                 710                 715                 720 


Leu Ala Glu Leu Glu Glu Gln Ala Ala Ser Ala Asn Lys Pro Asn Phe 
                725                 730                 735     


Arg Gly Thr Arg Cys Ile His Ser Gly Ala Met Pro Gln Asn Tyr Gln 
            740                 745                 750         


Asp Ser Leu Gly His Glu Val Ile Val Asn Asn Gln Cys Ser Thr Asn 
        755                 760                 765             


Ser Leu Gln Lys Gln Leu Gln Ala Val Leu Gln Trp Ile Ala Ala Ser 
    770                 775                 780                 


Gln Phe Asn Val Pro Met Leu Tyr Phe Met Gly Asp Lys Asp Gly Gln 
785                 790                 795                 800 


Leu Glu Lys Leu Pro Gln Val Ser Ala Lys Ala Ala Glu Lys Gly Tyr 
                805                 810                 815     


Ser Val Gly Gly Leu Leu Gln Glu Val Met Lys Phe Ala Lys Glu Arg 
            820                 825                 830         


Gln Pro Asp Glu Ala Val Gly Lys Val Ala Arg Lys Gln Leu Leu Asp 
        835                 840                 845             


Trp Leu Leu Ala Asn Leu 
    850                 


<210>  400
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP5__Homo_sapiens__NP_004848

<400>  400

Met Glu Thr Thr Ile Ser Glu Ile His Val Glu Asn Lys Asp Glu Lys 
1               5                   10                  15      


Arg Ser Ala Glu Gly Ser Pro Gly Ala Glu Arg Gln Lys Glu Lys Ala 
            20                  25                  30          


Ser Met Leu Cys Phe Lys Arg Arg Lys Lys Ala Ala Lys Ala Leu Lys 
        35                  40                  45              


Pro Lys Ala Gly Ser Glu Ala Ala Asp Val Ala Arg Lys Cys Pro Gln 
    50                  55                  60                  


Glu Ala Gly Ala Ser Asp Gln Pro Glu Pro Thr Arg Gly Ala Trp Ala 
65                  70                  75                  80  


Ser Leu Lys Arg Leu Val Thr Arg Arg Lys Arg Ser Glu Ser Ser Lys 
                85                  90                  95      


Gln Gln Lys Pro Leu Glu Gly Glu Met Gln Pro Ala Ile Asn Ala Glu 
            100                 105                 110         


Asp Ala Asp Leu Ser Lys Lys Lys Ala Lys Ser Arg Leu Lys Ile Pro 
        115                 120                 125             


Cys Ile Lys Phe Pro Arg Gly Pro Lys Arg Ser Asn His Ser Lys Ile 
    130                 135                 140                 


Ile Glu Asp Ser Asp Cys Ser Ile Lys Val Gln Glu Glu Ala Glu Ile 
145                 150                 155                 160 


Leu Asp Ile Gln Thr Gln Thr Pro Leu Asn Asp Gln Ala Thr Lys Ala 
                165                 170                 175     


Lys Ser Thr Gln Asp Leu Ser Glu Gly Ile Ser Arg Lys Asp Gly Asp 
            180                 185                 190         


Glu Val Cys Glu Ser Asn Val Ser Asn Ser Thr Thr Ser Gly Glu Lys 
        195                 200                 205             


Val Ile Ser Val Glu Leu Gly Leu Asp Asn Gly His Ser Ala Ile Gln 
    210                 215                 220                 


Thr Gly Thr Leu Ile Leu Glu Glu Ile Glu Thr Ile Lys Glu Lys Gln 
225                 230                 235                 240 


Asp Val Gln Pro Gln Gln Ala Ser Pro Leu Glu Thr Ser Glu Thr Asp 
                245                 250                 255     


His Gln Gln Pro Val Leu Ser Asp Val Pro Pro Leu Pro Ala Ile Pro 
            260                 265                 270         


Asp Gln Gln Ile Val Glu Glu Ala Ser Asn Ser Thr Leu Glu Ser Ala 
        275                 280                 285             


Pro Asn Gly Lys Asp Tyr Glu Ser Thr Glu Ile Val Ala Glu Glu Thr 
    290                 295                 300                 


Lys Pro Lys Asp Thr Glu Leu Ser Gln Glu Ser Asp Phe Lys Glu Asn 
305                 310                 315                 320 


Gly Ile Thr Glu Glu Lys Ser Lys Ser Glu Glu Ser Lys Arg Met Glu 
                325                 330                 335     


Pro Ile Ala Ile Ile Ile Thr Asp Thr Glu Ile Ser Glu Phe Asp Val 
            340                 345                 350         


Thr Lys Ser Lys Asn Val Pro Lys Gln Phe Leu Ile Ser Ala Glu Asn 
        355                 360                 365             


Glu Gln Val Gly Val Phe Ala Asn Asp Asn Gly Phe Glu Asp Arg Thr 
    370                 375                 380                 


Ser Glu Gln Tyr Glu Thr Leu Leu Ile Glu Thr Ala Ser Ser Leu Val 
385                 390                 395                 400 


Lys Asn Ala Ile Gln Leu Ser Ile Glu Gln Leu Val Asn Glu Met Ala 
                405                 410                 415     


Ser Asp Asp Asn Lys Ile Asn Asn Leu Leu Gln 
            420                 425         


<210>  401
<211>  2319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP6__Homo_sapiens__NP_004265

<400>  401

Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro 
            20                  25                  30          


Thr Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Thr Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg Met Thr 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Thr Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln Leu Thr 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Thr Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Thr Ser Ser Gln Val Lys Thr Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Thr Val Ala Ala Asp Ser Ile Ser Thr Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Thr Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Thr Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Thr Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Thr Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Thr 
        355                 360                 365             


Pro Lys Arg Thr Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Thr 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Thr Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Thr Ser Glu Glu Val Pro Pro Cys Arg Thr Pro Lys 
            500                 505                 510         


Arg Gly Thr Gly Ser Gly Lys Gln Ala Lys Asn Thr Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Thr Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Thr Asn Ser Ala Ser Thr Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Thr Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Thr Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Thr Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Thr Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Thr Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Thr Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Thr Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Thr Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Thr Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Lys  Thr Leu Gly 
    1040                 1045                 1050             


Glu Lys  Ile Gln Asp Thr Met  Ala Gly His Ser Gly  Ser Ser Pro 
    1055                 1060                 1065             


Arg Asp  Leu Leu Ser Pro Glu  Ser Gly Ser Leu Val  Arg Gln Leu 
    1070                 1075                 1080             


Glu Val  Arg Ile Lys Glu Leu  Lys Gly Trp Leu Arg  Asp Thr Glu 
    1085                 1090                 1095             


Leu Phe  Ile Phe Asn Ser Cys  Leu Arg Gln Glu Lys  Glu Gly Thr 
    1100                 1105                 1110             


Met Asn  Thr Glu Lys Gln Leu  Gln Tyr Phe Lys Ser  Leu Cys Arg 
    1115                 1120                 1125             


Glu Ile  Lys Gln Arg Arg Arg  Gly Val Ala Ser Ile  Leu Arg Leu 
    1130                 1135                 1140             


Cys Gln  His Leu Leu Asp Asp  Arg Glu Thr Cys Asn  Leu Asn Ala 
    1145                 1150                 1155             


Asp His  Gln Pro Met Gln Leu  Ile Ile Val Asn Leu  Glu Arg Arg 
    1160                 1165                 1170             


Trp Glu  Ala Ile Val Met Gln  Ala Val Gln Trp Gln  Thr Arg Leu 
    1175                 1180                 1185             


Gln Lys  Lys Met Gly Lys Glu  Ser Glu Thr Leu Asn  Val Ile Asp 
    1190                 1195                 1200             


Pro Gly  Leu Met Asp Leu Asn  Gly Met Ser Glu Asp  Ala Leu Glu 
    1205                 1210                 1215             


Trp Asp  Glu Met Asp Ile Ser  Asn Lys Leu Ile Ser  Leu Asn Glu 
    1220                 1225                 1230             


Glu Ser  Asn Asp Leu Asp Gln  Glu Leu Gln Pro Val  Ile Pro Ser 
    1235                 1240                 1245             


Leu Lys  Leu Gly Glu Thr Ser  Asn Glu Asp Pro Gly  Tyr Asp Glu 
    1250                 1255                 1260             


Glu Ala  Asp Asn His Gly Gly  Ser Gln Tyr Ala Ser  Asn Ile Thr 
    1265                 1270                 1275             


Ala Pro  Ser Ser Pro His Ile  Tyr Gln Val Tyr Ser  Leu His Asn 
    1280                 1285                 1290             


Val Glu  Leu Tyr Glu Asp Asn  His Met Pro Phe Leu  Lys Asn Asn 
    1295                 1300                 1305             


Pro Lys  Val Thr Gly Met Thr  Gln Pro Asn Val Leu  Thr Lys Ser 
    1310                 1315                 1320             


Leu Ser  Lys Asp Ser Ser Phe  Ser Ser Thr Lys Ser  Leu Pro Asp 
    1325                 1330                 1335             


Leu Leu  Gly Gly Ser Asn Leu  Val Lys Pro Cys Ala  Cys His Gly 
    1340                 1345                 1350             


Gly Asp  Met Ser Gln Asn Ser  Gly Ser Glu Ser Gly  Ile Val Ser 
    1355                 1360                 1365             


Glu Gly  Asp Thr Glu Thr Thr  Thr Asn Ser Glu Met  Cys Leu Leu 
    1370                 1375                 1380             


Asn Ala  Val Asp Gly Ser Pro  Ser Asn Leu Glu Thr  Glu His Leu 
    1385                 1390                 1395             


Asp Pro  Gln Met Gly Asp Ala  Val Asn Val Leu Lys  Gln Lys Phe 
    1400                 1405                 1410             


Thr Asp  Glu Gly Glu Ser Ile  Lys Leu Pro Asn Ser  Ser Gln Ser 
    1415                 1420                 1425             


Ser Ile  Ser Pro Val Gly Cys  Val Asn Gly Lys Val  Gly Asp Leu 
    1430                 1435                 1440             


Asn Ser  Ile Thr Lys His Thr  Pro Asp Cys Leu Gly  Glu Glu Leu 
    1445                 1450                 1455             


Gln Gly  Lys His Asp Val Phe  Thr Phe Tyr Asp Tyr  Ser Tyr Leu 
    1460                 1465                 1470             


Gln Gly  Ser Lys Leu Lys Leu  Pro Met Ile Met Lys  Gln Ser Gln 
    1475                 1480                 1485             


Ser Glu  Lys Ala His Val Glu  Asp Pro Leu Leu Arg  Gly Phe Tyr 
    1490                 1495                 1500             


Phe Asp  Lys Lys Ser Cys Lys  Ser Lys His Gln Thr  Thr Glu Leu 
    1505                 1510                 1515             


Gln Pro  Asp Val Pro Pro His  Glu Arg Ile Leu Ala  Ser Ala Ser 
    1520                 1525                 1530             


His Glu  Met Asp Arg Ile Ser  Tyr Lys Ser Gly Asn  Ile Glu Lys 
    1535                 1540                 1545             


Thr Phe  Thr Gly Met Gln Asn  Ala Lys Gln Leu Ser  Leu Leu Ser 
    1550                 1555                 1560             


His Ser  Ser Ser Ile Glu Ser  Leu Ser Pro Gly Gly  Asp Leu Phe 
    1565                 1570                 1575             


Gly Leu  Gly Ile Phe Lys Asn  Gly Ser Asp Ser Leu  Gln Arg Ser 
    1580                 1585                 1590             


Thr Ser  Leu Glu Ser Trp Leu  Thr Ser Tyr Lys Ser  Asn Glu Asp 
    1595                 1600                 1605             


Leu Phe  Ser Cys His Ser Ser  Gly Asp Ile Ser Val  Ser Ser Gly 
    1610                 1615                 1620             


Ser Val  Gly Glu Leu Ser Lys  Arg Thr Leu Asp Leu  Leu Asn Arg 
    1625                 1630                 1635             


Leu Glu  Asn Ile Gln Ser Pro  Ser Glu Gln Lys Ile  Lys Arg Ser 
    1640                 1645                 1650             


Val Ser  Asp Ile Thr Leu Gln  Ser Ser Ser Gln Lys  Met Ser Phe 
    1655                 1660                 1665             


Thr Gly  Gln Met Ser Leu Asp  Ile Ala Ser Ser Ile  Asn Glu Asp 
    1670                 1675                 1680             


Ser Ala  Ala Ser Leu Thr Glu  Leu Ser Ser Ser Asp  Glu Leu Ser 
    1685                 1690                 1695             


Leu Cys  Ser Glu Asp Ile Val  Leu His Lys Asn Lys  Ile Pro Glu 
    1700                 1705                 1710             


Ser Asn  Ala Ser Phe Arg Lys  Arg Leu Thr Arg Ser  Val Ala Asp 
    1715                 1720                 1725             


Glu Ser  Asp Val Asn Val Ser  Met Ile Val Asn Val  Ser Cys Thr 
    1730                 1735                 1740             


Ser Ala  Cys Thr Asp Asp Glu  Asp Asp Ser Asp Leu  Leu Ser Ser 
    1745                 1750                 1755             


Ser Thr  Leu Thr Leu Thr Glu  Glu Glu Leu Cys Ile  Lys Asp Glu 
    1760                 1765                 1770             


Asp Asp  Asp Ser Ser Ile Ala  Thr Asp Asp Glu Ile  Tyr Glu Asp 
    1775                 1780                 1785             


Cys Thr  Leu Met Ser Gly Leu  Asp Tyr Ile Lys Asn  Glu Leu Gln 
    1790                 1795                 1800             


Thr Trp  Ile Arg Pro Lys Leu  Ser Leu Thr Arg Asp  Lys Lys Arg 
    1805                 1810                 1815             


Cys Asn  Val Ser Asp Glu Met  Lys Gly Ser Lys Asp  Ile Ser Ser 
    1820                 1825                 1830             


Ser Glu  Met Thr Asn Pro Ser  Asp Thr Leu Asn Ile  Glu Thr Leu 
    1835                 1840                 1845             


Leu Asn  Gly Ser Val Lys Arg  Val Ser Glu Asn Asn  Gly Asn Gly 
    1850                 1855                 1860             


Lys Asn  Ser Ser His Thr His  Glu Leu Gly Thr Lys  Arg Glu Asn 
    1865                 1870                 1875             


Lys Lys  Thr Ile Phe Lys Val  Asn Lys Asp Pro Tyr  Val Ala Asp 
    1880                 1885                 1890             


Met Glu  Asn Gly Asn Ile Glu  Gly Ile Pro Glu Arg  Gln Lys Gly 
    1895                 1900                 1905             


Lys Pro  Asn Val Thr Ser Lys  Val Ser Glu Asn Leu  Gly Ser His 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Glu Ser  Glu His Cys Lys Cys  Lys Ala Leu 
    1925                 1930                 1935             


Met Asp  Ser Leu Asp Asp Ser  Asn Thr Ala Gly Lys  Glu Phe Val 
    1940                 1945                 1950             


Ser Gln  Asp Val Arg His Leu  Pro Lys Lys Cys Pro  Asn His His 
    1955                 1960                 1965             


His Phe  Glu Asn Gln Ser Thr  Ala Ser Thr Pro Thr  Glu Lys Ser 
    1970                 1975                 1980             


Phe Ser  Glu Leu Ala Leu Glu  Thr Arg Phe Asn Asn  Arg Gln Asp 
    1985                 1990                 1995             


Ser Asp  Ala Leu Lys Ser Ser  Asp Asp Ala Pro Ser  Met Ala Gly 
    2000                 2005                 2010             


Lys Ser  Ala Gly Cys Cys Leu  Ala Leu Glu Gln Asn  Gly Thr Glu 
    2015                 2020                 2025             


Glu Asn  Ala Ser Ile Ser Asn  Ile Ser Cys Cys Asn  Cys Glu Pro 
    2030                 2035                 2040             


Asp Val  Phe His Gln Lys Asp  Ala Glu Asp Cys Ser  Val His Asn 
    2045                 2050                 2055             


Phe Val  Lys Glu Ile Ile Asp  Met Ala Ser Thr Ala  Leu Lys Ser 
    2060                 2065                 2070             


Lys Ser  Gln Pro Glu Asn Glu  Val Ala Ala Pro Thr  Ser Leu Thr 
    2075                 2080                 2085             


Gln Ile  Lys Glu Lys Val Leu  Glu His Ser His Arg  Pro Ile Gln 
    2090                 2095                 2100             


Leu Arg  Lys Gly Asp Phe Tyr  Ser Tyr Leu Ser Leu  Ser Ser His 
    2105                 2110                 2115             


Asp Ser  Asp Cys Gly Glu Val  Thr Asn Tyr Ile Glu  Glu Lys Ser 
    2120                 2125                 2130             


Ser Thr  Pro Leu Pro Leu Asp  Thr Thr Asp Ser Gly  Leu Asp Asp 
    2135                 2140                 2145             


Lys Glu  Asp Ile Glu Cys Phe  Phe Glu Ala Cys Val  Glu Gly Asp 
    2150                 2155                 2160             


Ser Asp  Gly Glu Glu Pro Cys  Phe Ser Ser Ala Pro  Pro Asn Glu 
    2165                 2170                 2175             


Ser Ala  Val Pro Ser Glu Ala  Ala Met Pro Leu Gln  Ala Thr Ala 
    2180                 2185                 2190             


Cys Ser  Ser Glu Phe Ser Asp  Ser Ser Leu Ser Ala  Asp Asp Ala 
    2195                 2200                 2205             


Asp Thr  Val Ala Leu Ser Ser  Pro Ser Ser Gln Glu  Arg Ala Glu 
    2210                 2215                 2220             


Val Gly  Lys Glu Val Asn Gly  Leu Pro Gln Thr Ser  Ser Gly Cys 
    2225                 2230                 2235             


Ala Glu  Asn Leu Glu Phe Thr  Pro Ser Lys Leu Asp  Ser Glu Lys 
    2240                 2245                 2250             


Glu Ser  Ser Gly Lys Pro Gly  Glu Ser Gly Met Pro  Glu Glu His 
    2255                 2260                 2265             


Asn Ala  Ala Ser Ala Lys Ser  Lys Val Gln Asp Leu  Ser Leu Lys 
    2270                 2275                 2280             


Ala Asn  Gln Pro Thr Asp Lys  Ala Ala Leu His Pro  Ser Pro Lys 
    2285                 2290                 2295             


Thr Leu  Thr Cys Glu Glu Asn  Leu Leu Asn Leu His  Glu Lys Arg 
    2300                 2305                 2310             


His Arg  Asn Met His Arg 
    2315                 


<210>  402
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP7__Homo_sapiens__NP_004833

<400>  402

Met Gly Gln Leu Cys Cys Phe Pro Phe Ser Arg Asp Glu Gly Lys Ile 
1               5                   10                  15      


Ser Glu Lys Asn Gly Gly Glu Pro Asp Asp Ala Glu Leu Val Arg Leu 
            20                  25                  30          


Ser Lys Arg Leu Val Glu Asn Ala Val Leu Lys Ala Val Gln Gln Tyr 
        35                  40                  45              


Leu Glu Glu Thr Gln Asn Lys Asn Lys Pro Gly Glu Gly Ser Ser Val 
    50                  55                  60                  


Lys Thr Glu Ala Ala Asp Gln Asn Gly Asn Asp Asn Glu Asn Asn Arg 
65                  70                  75                  80  


Lys 
    


<210>  403
<211>  3907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP9__Homo_sapiens__NP_005742

<400>  403

Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Leu Ala Gln Phe Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro 
            20                  25                  30          


Ser Lys Lys Gln Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp 
        35                  40                  45              


Val Ser Ala His His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu 
    50                  55                  60                  


Met Tyr Ile Asn Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu 
65                  70                  75                  80  


Ser Thr Ile Met Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu 
                85                  90                  95      


Gln Gly Phe Ser Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp 
            100                 105                 110         


Asp Cys Ser Ser Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly 
        115                 120                 125             


Lys Pro Thr Asn Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser 
    130                 135                 140                 


Tyr Ser Glu Gln Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met 
145                 150                 155                 160 


Glu Ser Glu Leu Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg 
                165                 170                 175     


Glu Leu Glu Glu Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln 
            180                 185                 190         


Leu Gln Glu Phe Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr 
        195                 200                 205             


Gln Leu Thr Ala Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr 
    210                 215                 220                 


Met Arg Glu Phe Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile 
225                 230                 235                 240 


Gln Phe Gln Gln Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His 
                245                 250                 255     


Ser Ser Thr Ala Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr 
            260                 265                 270         


His Gln Gln Gln Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln 
        275                 280                 285             


Lys Lys Lys Glu Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys 
    290                 295                 300                 


Ile Lys Val Tyr Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn 
305                 310                 315                 320 


Lys Glu Glu Ile Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr 
                325                 330                 335     


Lys Ile Ile Glu Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu 
            340                 345                 350         


Thr Thr Ala Asp Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln 
        355                 360                 365             


Lys Asn Gln Glu Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys 
    370                 375                 380                 


Gln Lys Glu Arg Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr 
385                 390                 395                 400 


Val Glu Glu Leu Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr 
                405                 410                 415     


Asp Ile Val Gln Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln 
            420                 425                 430         


Leu Arg Ala Glu Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met 
        435                 440                 445             


Lys Gln Glu Leu Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys 
    450                 455                 460                 


Thr Arg His Lys Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn 
465                 470                 475                 480 


Ile Thr Val Asn Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn 
                485                 490                 495     


Glu Leu Asn Ile Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu 
            500                 505                 510         


Lys Glu Glu Leu Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg 
        515                 520                 525             


Gln Leu Glu Asp Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile 
    530                 535                 540                 


Gln Arg Ala Arg Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu 
545                 550                 555                 560 


Ala His Lys Ser Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val 
                565                 570                 575     


Ser Ala Ser Glu Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu 
            580                 585                 590         


Val Thr Asn Tyr Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn 
        595                 600                 605             


Ala Val Leu Asp Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg 
    610                 615                 620                 


Leu Arg Thr Gln Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu 
625                 630                 635                 640 


Lys Glu Asp Leu Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys 
                645                 650                 655     


Asp Asn Leu Gly Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn 
            660                 665                 670         


Glu Met Ser Gln Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu 
        675                 680                 685             


Ile Thr Lys Gln Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp 
    690                 695                 700                 


Leu Gln Gln Ser Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln 
705                 710                 715                 720 


Ile Asn Glu Leu Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys 
                725                 730                 735     


Glu Lys Gly Thr Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr 
            740                 745                 750         


Glu Leu Leu Glu Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu 
        755                 760                 765             


Lys Phe Ala Gln Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys 
    770                 775                 780                 


Lys Thr Leu Glu Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu 
785                 790                 795                 800 


Glu Arg Leu Ile Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser 
                805                 810                 815     


Val Trp Glu Lys Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu 
            820                 825                 830         


Lys Gln Gln Cys Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn 
        835                 840                 845             


Thr Phe Ser Phe Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu 
    850                 855                 860                 


Gln Glu Glu Tyr Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp 
865                 870                 875                 880 


Ser Lys Asn Lys Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu 
                885                 890                 895     


Asn Glu Glu Leu His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met 
            900                 905                 910         


Lys Ser Ser Val Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu 
        915                 920                 925             


Glu Met Gly Glu Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys 
    930                 935                 940                 


Leu Glu Val Thr Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser 
945                 950                 955                 960 


Asp Leu Ser Glu Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu 
                965                 970                 975     


Asn Glu Glu Val Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu 
            980                 985                 990         


Arg Cys Arg Glu Leu Glu Ile Ile  Ile Asn His Asn Arg  Ala Glu Asn 
        995                 1000                 1005             


Val Gln  Ser Cys Asp Thr Gln  Val Ser Ser Leu Leu  Asp Gly Val 
    1010                 1015                 1020             


Val Thr  Met Thr Ser Arg Gly  Ala Glu Gly Ser Val  Ser Lys Val 
    1025                 1030                 1035             


Asn Lys  Ser Phe Gly Glu Glu  Ser Lys Ile Met Val  Glu Asp Lys 
    1040                 1045                 1050             


Val Ser  Phe Glu Asn Met Thr  Val Gly Glu Glu Ser  Lys Gln Glu 
    1055                 1060                 1065             


Gln Leu  Ile Leu Asp His Leu  Pro Ser Val Thr Lys  Glu Ser Ser 
    1070                 1075                 1080             


Leu Arg  Ala Thr Gln Pro Ser  Glu Asn Asp Lys Leu  Gln Lys Glu 
    1085                 1090                 1095             


Leu Asn  Val Leu Lys Ser Glu  Gln Asn Asp Leu Arg  Leu Gln Met 
    1100                 1105                 1110             


Glu Ala  Gln Arg Ile Cys Leu  Ser Leu Val Tyr Ser  Thr His Val 
    1115                 1120                 1125             


Asp Gln  Val Arg Glu Tyr Met  Glu Asn Glu Lys Asp  Lys Ala Leu 
    1130                 1135                 1140             


Cys Ser  Leu Lys Glu Glu Leu  Ile Phe Ala Gln Glu  Glu Lys Ile 
    1145                 1150                 1155             


Lys Glu  Leu Gln Lys Ile His  Gln Leu Glu Leu Gln  Thr Met Lys 
    1160                 1165                 1170             


Thr Gln  Glu Thr Gly Asp Glu  Gly Lys Pro Leu His  Leu Leu Ile 
    1175                 1180                 1185             


Gly Lys  Leu Gln Lys Ala Val  Ser Glu Glu Cys Ser  Tyr Phe Leu 
    1190                 1195                 1200             


Gln Thr  Leu Cys Ser Val Leu  Gly Glu Tyr Tyr Thr  Pro Ala Leu 
    1205                 1210                 1215             


Lys Cys  Glu Val Asn Ala Glu  Asp Lys Glu Asn Ser  Gly Asp Tyr 
    1220                 1225                 1230             


Ile Ser  Glu Asn Glu Asp Pro  Glu Leu Gln Asp Tyr  Arg Tyr Glu 
    1235                 1240                 1245             


Val Gln  Asp Phe Gln Glu Asn  Met His Thr Leu Leu  Asn Lys Val 
    1250                 1255                 1260             


Thr Glu  Glu Tyr Asn Lys Leu  Leu Val Leu Gln Thr  Arg Leu Ser 
    1265                 1270                 1275             


Lys Ile  Trp Gly Gln Gln Thr  Asp Gly Met Lys Leu  Glu Phe Gly 
    1280                 1285                 1290             


Glu Glu  Asn Leu Pro Lys Glu  Glu Thr Glu Phe Leu  Ser Ile His 
    1295                 1300                 1305             


Ser Gln  Met Thr Asn Leu Glu  Asp Ile Asp Val Asn  His Lys Ser 
    1310                 1315                 1320             


Lys Leu  Ser Ser Leu Gln Asp  Leu Glu Lys Thr Lys  Leu Glu Glu 
    1325                 1330                 1335             


Gln Val  Gln Glu Leu Glu Ser  Leu Ile Ser Ser Leu  Gln Gln Gln 
    1340                 1345                 1350             


Leu Lys  Glu Thr Glu Gln Asn  Tyr Glu Ala Glu Ile  His Cys Leu 
    1355                 1360                 1365             


Gln Lys  Arg Leu Gln Ala Val  Ser Glu Ser Thr Val  Pro Pro Ser 
    1370                 1375                 1380             


Leu Pro  Val Asp Ser Val Val  Ile Thr Glu Ser Asp  Ala Gln Arg 
    1385                 1390                 1395             


Thr Met  Tyr Pro Gly Ser Cys  Val Lys Lys Asn Ile  Asp Gly Thr 
    1400                 1405                 1410             


Ile Glu  Phe Ser Gly Glu Phe  Gly Val Lys Glu Glu  Thr Asn Ile 
    1415                 1420                 1425             


Val Lys  Leu Leu Glu Lys Gln  Tyr Gln Glu Gln Leu  Glu Glu Glu 
    1430                 1435                 1440             


Val Ala  Lys Val Ile Val Ser  Met Ser Ile Ala Phe  Ala Gln Gln 
    1445                 1450                 1455             


Thr Glu  Leu Ser Arg Ile Ser  Gly Gly Lys Glu Asn  Thr Ala Ser 
    1460                 1465                 1470             


Ser Lys  Gln Ala His Ala Val  Cys Gln Gln Glu Gln  His Tyr Phe 
    1475                 1480                 1485             


Asn Glu  Met Lys Leu Ser Gln  Asp Gln Ile Gly Phe  Gln Thr Phe 
    1490                 1495                 1500             


Glu Thr  Val Asp Val Lys Phe  Lys Glu Glu Phe Lys  Pro Leu Ser 
    1505                 1510                 1515             


Lys Glu  Leu Gly Glu His Gly  Lys Glu Ile Leu Leu  Ser Asn Ser 
    1520                 1525                 1530             


Asp Pro  His Asp Ile Pro Glu  Ser Lys Asp Cys Val  Leu Thr Ile 
    1535                 1540                 1545             


Ser Glu  Glu Met Phe Ser Lys  Asp Lys Thr Phe Ile  Val Arg Gln 
    1550                 1555                 1560             


Ser Ile  His Asp Glu Ile Ser  Val Ser Ser Met Asp  Ala Ser Arg 
    1565                 1570                 1575             


Gln Leu  Met Leu Asn Glu Glu  Gln Leu Glu Asp Met  Arg Gln Glu 
    1580                 1585                 1590             


Leu Val  Arg Gln Tyr Gln Glu  His Gln Gln Ala Thr  Glu Leu Leu 
    1595                 1600                 1605             


Arg Gln  Ala His Met Arg Gln  Met Glu Arg Gln Arg  Glu Asp Gln 
    1610                 1615                 1620             


Glu Gln  Leu Gln Glu Glu Ile  Lys Arg Leu Asn Arg  Gln Leu Ala 
    1625                 1630                 1635             


Gln Arg  Ser Ser Ile Asp Asn  Glu Asn Leu Val Ser  Glu Arg Glu 
    1640                 1645                 1650             


Arg Val  Leu Leu Glu Glu Leu  Glu Ala Leu Lys Gln  Leu Ser Leu 
    1655                 1660                 1665             


Ala Gly  Arg Glu Lys Leu Cys  Cys Glu Leu Arg Asn  Ser Ser Thr 
    1670                 1675                 1680             


Gln Thr  Gln Asn Gly Asn Glu  Asn Gln Gly Glu Val  Glu Glu Gln 
    1685                 1690                 1695             


Thr Phe  Lys Glu Lys Glu Leu  Asp Arg Lys Pro Glu  Asp Val Pro 
    1700                 1705                 1710             


Pro Glu  Ile Leu Ser Asn Glu  Arg Tyr Ala Leu Gln  Lys Ala Asn 
    1715                 1720                 1725             


Asn Arg  Leu Leu Lys Ile Leu  Leu Glu Val Val Lys  Thr Thr Ala 
    1730                 1735                 1740             


Ala Val  Glu Glu Thr Ile Gly  Arg His Val Leu Gly  Ile Leu Asp 
    1745                 1750                 1755             


Arg Ser  Ser Lys Ser Gln Ser  Ser Ala Ser Leu Ile  Trp Arg Ser 
    1760                 1765                 1770             


Glu Ala  Glu Ala Ser Val Lys  Ser Cys Val His Glu  Glu His Thr 
    1775                 1780                 1785             


Arg Val  Thr Asp Glu Ser Ile  Pro Ser Tyr Ser Gly  Ser Asp Met 
    1790                 1795                 1800             


Pro Arg  Asn Asp Ile Asn Met  Trp Ser Lys Val Thr  Glu Glu Gly 
    1805                 1810                 1815             


Thr Glu  Leu Ser Gln Arg Leu  Val Arg Ser Gly Phe  Ala Gly Thr 
    1820                 1825                 1830             


Glu Ile  Asp Pro Glu Asn Glu  Glu Leu Met Leu Asn  Ile Ser Ser 
    1835                 1840                 1845             


Arg Leu  Gln Ala Ala Val Glu  Lys Leu Leu Glu Ala  Ile Ser Glu 
    1850                 1855                 1860             


Thr Ser  Ser Gln Leu Glu His  Ala Lys Val Thr Gln  Thr Glu Leu 
    1865                 1870                 1875             


Met Arg  Glu Ser Phe Arg Gln  Lys Gln Glu Ala Thr  Glu Ser Leu 
    1880                 1885                 1890             


Lys Cys  Gln Glu Glu Leu Arg  Glu Arg Leu His Glu  Glu Ser Arg 
    1895                 1900                 1905             


Ala Arg  Glu Gln Leu Ala Val  Glu Leu Ser Lys Ala  Glu Gly Val 
    1910                 1915                 1920             


Ile Asp  Gly Tyr Ala Asp Glu  Lys Thr Leu Phe Glu  Arg Gln Ile 
    1925                 1930                 1935             


Gln Glu  Lys Thr Asp Ile Ile  Asp Arg Leu Glu Gln  Glu Leu Leu 
    1940                 1945                 1950             


Cys Ala  Ser Asn Arg Leu Gln  Glu Leu Glu Ala Glu  Gln Gln Gln 
    1955                 1960                 1965             


Ile Gln  Glu Glu Arg Glu Leu  Leu Ser Arg Gln Lys  Glu Ala Met 
    1970                 1975                 1980             


Lys Ala  Glu Ala Gly Pro Val  Glu Gln Gln Leu Leu  Gln Glu Thr 
    1985                 1990                 1995             


Glu Lys  Leu Met Lys Glu Lys  Leu Glu Val Gln Cys  Gln Ala Glu 
    2000                 2005                 2010             


Lys Val  Arg Asp Asp Leu Gln  Lys Gln Val Lys Ala  Leu Glu Ile 
    2015                 2020                 2025             


Asp Val  Glu Glu Gln Val Ser  Arg Phe Ile Glu Leu  Glu Gln Glu 
    2030                 2035                 2040             


Lys Asn  Thr Glu Leu Met Asp  Leu Arg Gln Gln Asn  Gln Ala Leu 
    2045                 2050                 2055             


Glu Lys  Gln Leu Glu Lys Met  Arg Lys Phe Leu Asp  Glu Gln Ala 
    2060                 2065                 2070             


Ile Asp  Arg Glu His Glu Arg  Asp Val Phe Gln Gln  Glu Ile Gln 
    2075                 2080                 2085             


Lys Leu  Glu Gln Gln Leu Lys  Val Val Pro Arg Phe  Gln Pro Ile 
    2090                 2095                 2100             


Ser Glu  His Gln Thr Arg Glu  Val Glu Gln Leu Ala  Asn His Leu 
    2105                 2110                 2115             


Lys Glu  Lys Thr Asp Lys Cys  Ser Glu Leu Leu Leu  Ser Lys Glu 
    2120                 2125                 2130             


Gln Leu  Gln Arg Asp Ile Gln  Glu Arg Asn Glu Glu  Ile Glu Lys 
    2135                 2140                 2145             


Leu Glu  Phe Arg Val Arg Glu  Leu Glu Gln Ala Leu  Leu Val Ser 
    2150                 2155                 2160             


Ala Asp  Thr Phe Gln Lys Val  Glu Asp Arg Lys His  Phe Gly Ala 
    2165                 2170                 2175             


Val Glu  Ala Lys Pro Glu Leu  Ser Leu Glu Val Gln  Leu Gln Ala 
    2180                 2185                 2190             


Glu Arg  Asp Ala Ile Asp Arg  Lys Glu Lys Glu Ile  Thr Asn Leu 
    2195                 2200                 2205             


Glu Glu  Gln Leu Glu Gln Phe  Arg Glu Glu Leu Glu  Asn Lys Asn 
    2210                 2215                 2220             


Glu Glu  Val Gln Gln Leu His  Met Gln Leu Glu Ile  Gln Lys Lys 
    2225                 2230                 2235             


Glu Ser  Thr Thr Arg Leu Gln  Glu Leu Glu Gln Glu  Asn Lys Leu 
    2240                 2245                 2250             


Phe Lys  Asp Asp Met Glu Lys  Leu Gly Leu Ala Ile  Lys Glu Ser 
    2255                 2260                 2265             


Asp Ala  Met Ser Thr Gln Asp  Gln His Val Leu Phe  Gly Lys Phe 
    2270                 2275                 2280             


Ala Gln  Ile Ile Gln Glu Lys  Glu Val Glu Ile Asp  Gln Leu Asn 
    2285                 2290                 2295             


Glu Gln  Val Thr Lys Leu Gln  Gln Gln Leu Lys Ile  Thr Thr Asp 
    2300                 2305                 2310             


Asn Lys  Val Ile Glu Glu Lys  Asn Glu Leu Ile Arg  Asp Leu Glu 
    2315                 2320                 2325             


Thr Gln  Ile Glu Cys Leu Met  Ser Asp Gln Glu Cys  Val Lys Arg 
    2330                 2335                 2340             


Asn Arg  Glu Glu Glu Ile Glu  Gln Leu Asn Glu Val  Ile Glu Lys 
    2345                 2350                 2355             


Leu Gln  Gln Glu Leu Ala Asn  Ile Gly Gln Lys Thr  Ser Met Asn 
    2360                 2365                 2370             


Ala His  Ser Leu Ser Glu Glu  Ala Asp Ser Leu Lys  His Gln Leu 
    2375                 2380                 2385             


Asp Val  Val Ile Ala Glu Lys  Leu Ala Leu Glu Gln  Gln Val Glu 
    2390                 2395                 2400             


Thr Ala  Asn Glu Glu Met Thr  Phe Met Lys Asn Val  Leu Lys Glu 
    2405                 2410                 2415             


Thr Asn  Phe Lys Met Asn Gln  Leu Thr Gln Glu Leu  Phe Ser Leu 
    2420                 2425                 2430             


Lys Arg  Glu Arg Glu Ser Val  Glu Lys Ile Gln Ser  Ile Pro Glu 
    2435                 2440                 2445             


Asn Ser  Val Asn Val Ala Ile  Asp His Leu Ser Lys  Asp Lys Pro 
    2450                 2455                 2460             


Glu Leu  Glu Val Val Leu Thr  Glu Asp Ala Leu Lys  Ser Leu Glu 
    2465                 2470                 2475             


Asn Gln  Thr Tyr Phe Lys Ser  Phe Glu Glu Asn Gly  Lys Gly Ser 
    2480                 2485                 2490             


Ile Ile  Asn Leu Glu Thr Arg  Leu Leu Gln Leu Glu  Ser Thr Val 
    2495                 2500                 2505             


Ser Ala  Lys Asp Leu Glu Leu  Thr Gln Cys Tyr Lys  Gln Ile Lys 
    2510                 2515                 2520             


Asp Met  Gln Glu Gln Gly Gln  Phe Glu Thr Glu Met  Leu Gln Lys 
    2525                 2530                 2535             


Lys Ile  Val Asn Leu Gln Lys  Ile Val Glu Glu Lys  Val Ala Ala 
    2540                 2545                 2550             


Ala Leu  Val Ser Gln Ile Gln  Leu Glu Ala Val Gln  Glu Tyr Ala 
    2555                 2560                 2565             


Lys Phe  Cys Gln Asp Asn Gln  Thr Ile Ser Ser Glu  Pro Glu Arg 
    2570                 2575                 2580             


Thr Asn  Ile Gln Asn Leu Asn  Gln Leu Arg Glu Asp  Glu Leu Gly 
    2585                 2590                 2595             


Ser Asp  Ile Ser Ala Leu Thr  Leu Arg Ile Ser Glu  Leu Glu Ser 
    2600                 2605                 2610             


Gln Val  Val Glu Met His Thr  Ser Leu Ile Leu Glu  Lys Glu Gln 
    2615                 2620                 2625             


Val Glu  Ile Ala Glu Lys Asn  Val Leu Glu Lys Glu  Lys Lys Leu 
    2630                 2635                 2640             


Leu Glu  Leu Gln Lys Leu Leu  Glu Gly Asn Glu Lys  Lys Gln Arg 
    2645                 2650                 2655             


Glu Lys  Glu Lys Lys Arg Ser  Pro Gln Asp Val Glu  Val Leu Lys 
    2660                 2665                 2670             


Thr Thr  Thr Glu Leu Phe His  Ser Asn Glu Glu Ser  Gly Phe Phe 
    2675                 2680                 2685             


Asn Glu  Leu Glu Ala Leu Arg  Ala Glu Ser Val Ala  Thr Lys Ala 
    2690                 2695                 2700             


Glu Leu  Ala Ser Tyr Lys Glu  Lys Ala Glu Lys Leu  Gln Glu Glu 
    2705                 2710                 2715             


Leu Leu  Val Lys Glu Thr Asn  Met Thr Ser Leu Gln  Lys Asp Leu 
    2720                 2725                 2730             


Ser Gln  Val Arg Asp His Leu  Ala Glu Ala Lys Glu  Lys Leu Ser 
    2735                 2740                 2745             


Ile Leu  Glu Lys Glu Asp Glu  Thr Glu Val Gln Glu  Ser Lys Lys 
    2750                 2755                 2760             


Ala Cys  Met Phe Glu Pro Leu  Pro Ile Lys Leu Ser  Lys Ser Ile 
    2765                 2770                 2775             


Ala Ser  Gln Thr Asp Gly Thr  Leu Lys Ile Ser Ser  Ser Asn Gln 
    2780                 2785                 2790             


Thr Pro  Gln Ile Leu Val Lys  Asn Ala Gly Ile Gln  Ile Asn Leu 
    2795                 2800                 2805             


Gln Ser  Glu Cys Ser Ser Glu  Glu Val Thr Glu Ile  Ile Ser Gln 
    2810                 2815                 2820             


Phe Thr  Glu Lys Ile Glu Lys  Met Gln Glu Leu His  Ala Ala Glu 
    2825                 2830                 2835             


Ile Leu  Asp Met Glu Ser Arg  His Ile Ser Glu Thr  Glu Thr Leu 
    2840                 2845                 2850             


Lys Arg  Glu His Tyr Val Ala  Val Gln Leu Leu Lys  Glu Glu Cys 
    2855                 2860                 2865             


Gly Thr  Leu Lys Ala Val Ile  Gln Cys Leu Arg Ser  Lys Glu Gly 
    2870                 2875                 2880             


Ser Ser  Ile Pro Glu Leu Ala  His Ser Asp Ala Tyr  Gln Thr Arg 
    2885                 2890                 2895             


Glu Ile  Cys Ser Ser Asp Ser  Gly Ser Asp Trp Gly  Gln Gly Ile 
    2900                 2905                 2910             


Tyr Leu  Thr His Ser Gln Gly  Phe Asp Ile Ala Ser  Glu Gly Arg 
    2915                 2920                 2925             


Gly Glu  Glu Ser Glu Ser Ala  Thr Asp Ser Phe Pro  Lys Lys Ile 
    2930                 2935                 2940             


Lys Gly  Leu Leu Arg Ala Val  His Asn Glu Gly Met  Gln Val Leu 
    2945                 2950                 2955             


Ser Leu  Thr Glu Ser Pro Tyr  Ser Asp Gly Glu Asp  His Ser Ile 
    2960                 2965                 2970             


Gln Gln  Val Ser Glu Pro Trp  Leu Glu Glu Arg Lys  Ala Tyr Ile 
    2975                 2980                 2985             


Asn Thr  Ile Ser Ser Leu Lys  Asp Leu Ile Thr Lys  Met Gln Leu 
    2990                 2995                 3000             


Gln Arg  Glu Ala Glu Val Tyr  Asp Ser Ser Gln Ser  His Glu Ser 
    3005                 3010                 3015             


Phe Ser  Asp Trp Arg Gly Glu  Leu Leu Leu Ala Leu  Gln Gln Val 
    3020                 3025                 3030             


Phe Leu  Glu Glu Arg Ser Val  Leu Leu Ala Ala Phe  Arg Thr Glu 
    3035                 3040                 3045             


Leu Thr  Ala Leu Gly Thr Thr  Asp Ala Val Gly Leu  Leu Asn Cys 
    3050                 3055                 3060             


Leu Glu  Gln Arg Ile Gln Glu  Gln Gly Val Glu Tyr  Gln Ala Ala 
    3065                 3070                 3075             


Met Glu  Cys Leu Gln Lys Ala  Asp Arg Arg Ser Leu  Leu Ser Glu 
    3080                 3085                 3090             


Ile Gln  Ala Leu His Ala Gln  Met Asn Gly Arg Lys  Ile Thr Leu 
    3095                 3100                 3105             


Lys Arg  Glu Gln Glu Ser Glu  Lys Pro Ser Gln Glu  Leu Leu Glu 
    3110                 3115                 3120             


Tyr Asn  Ile Gln Gln Lys Gln  Ser Gln Met Leu Glu  Met Gln Val 
    3125                 3130                 3135             


Glu Leu  Ser Ser Met Lys Asp  Arg Ala Thr Glu Leu  Gln Glu Gln 
    3140                 3145                 3150             


Leu Ser  Ser Glu Lys Met Val  Val Ala Glu Leu Lys  Ser Glu Leu 
    3155                 3160                 3165             


Ala Gln  Thr Lys Leu Glu Leu  Glu Thr Thr Leu Lys  Ala Gln His 
    3170                 3175                 3180             


Lys His  Leu Lys Glu Leu Glu  Ala Phe Arg Leu Glu  Val Lys Asp 
    3185                 3190                 3195             


Lys Thr  Asp Glu Val His Leu  Leu Asn Asp Thr Leu  Ala Ser Glu 
    3200                 3205                 3210             


Gln Lys  Lys Ser Arg Glu Leu  Gln Trp Ala Leu Glu  Lys Glu Lys 
    3215                 3220                 3225             


Ala Lys  Leu Gly Arg Ser Glu  Glu Arg Asp Lys Glu  Glu Leu Glu 
    3230                 3235                 3240             


Asp Leu  Lys Phe Ser Leu Glu  Ser Gln Lys Gln Arg  Asn Leu Gln 
    3245                 3250                 3255             


Leu Asn  Leu Leu Leu Glu Gln  Gln Lys Gln Leu Leu  Asn Glu Ser 
    3260                 3265                 3270             


Gln Gln  Lys Ile Glu Ser Gln  Arg Met Leu Tyr Asp  Ala Gln Leu 
    3275                 3280                 3285             


Ser Glu  Glu Gln Gly Arg Asn  Leu Glu Leu Gln Val  Leu Leu Glu 
    3290                 3295                 3300             


Ser Glu  Lys Val Arg Ile Arg  Glu Met Ser Ser Thr  Leu Asp Arg 
    3305                 3310                 3315             


Glu Arg  Glu Leu His Ala Gln  Leu Gln Ser Ser Asp  Gly Thr Gly 
    3320                 3325                 3330             


Gln Ser  Arg Pro Pro Leu Pro  Ser Glu Asp Leu Leu  Lys Glu Leu 
    3335                 3340                 3345             


Gln Lys  Gln Leu Glu Glu Lys  His Ser Arg Ile Val  Glu Leu Leu 
    3350                 3355                 3360             


Asn Glu  Thr Glu Lys Tyr Lys  Leu Asp Ser Leu Gln  Thr Arg Gln 
    3365                 3370                 3375             


Gln Met  Glu Lys Asp Arg Gln  Val His Arg Lys Thr  Leu Gln Thr 
    3380                 3385                 3390             


Glu Gln  Glu Ala Asn Thr Glu  Gly Gln Lys Lys Met  His Glu Leu 
    3395                 3400                 3405             


Gln Ser  Lys Val Glu Asp Leu  Gln Arg Gln Leu Glu  Glu Lys Arg 
    3410                 3415                 3420             


Gln Gln  Val Tyr Lys Leu Asp  Leu Glu Gly Gln Arg  Leu Gln Gly 
    3425                 3430                 3435             


Ile Met  Gln Glu Phe Gln Lys  Gln Glu Leu Glu Arg  Glu Glu Lys 
    3440                 3445                 3450             


Arg Glu  Ser Arg Arg Ile Leu  Tyr Gln Asn Leu Asn  Glu Pro Thr 
    3455                 3460                 3465             


Thr Trp  Ser Leu Thr Ser Asp  Arg Thr Arg Asn Trp  Val Leu Gln 
    3470                 3475                 3480             


Gln Lys  Ile Glu Gly Glu Thr  Lys Glu Ser Asn Tyr  Ala Lys Leu 
    3485                 3490                 3495             


Ile Glu  Met Asn Gly Gly Gly  Thr Gly Cys Asn His  Glu Leu Glu 
    3500                 3505                 3510             


Met Ile  Arg Gln Lys Leu Gln  Cys Val Ala Ser Lys  Leu Gln Val 
    3515                 3520                 3525             


Leu Pro  Gln Lys Ala Ser Glu  Arg Leu Gln Phe Glu  Thr Ala Asp 
    3530                 3535                 3540             


Asp Glu  Asp Phe Ile Trp Val  Gln Glu Asn Ile Asp  Glu Ile Ile 
    3545                 3550                 3555             


Leu Gln  Leu Gln Lys Leu Thr  Gly Gln Gln Gly Glu  Glu Pro Ser 
    3560                 3565                 3570             


Leu Val  Ser Pro Ser Thr Ser  Cys Gly Ser Leu Thr  Glu Arg Leu 
    3575                 3580                 3585             


Leu Arg  Gln Asn Ala Glu Leu  Thr Gly His Ile Ser  Gln Leu Thr 
    3590                 3595                 3600             


Glu Glu  Lys Asn Asp Leu Arg  Asn Met Val Met Lys  Leu Glu Glu 
    3605                 3610                 3615             


Gln Ile  Arg Trp Tyr Arg Gln  Thr Gly Ala Gly Arg  Asp Asn Ser 
    3620                 3625                 3630             


Ser Arg  Phe Ser Leu Asn Gly  Gly Ala Asn Ile Glu  Ala Ile Ile 
    3635                 3640                 3645             


Ala Ser  Glu Lys Glu Val Trp  Asn Arg Glu Lys Leu  Thr Leu Gln 
    3650                 3655                 3660             


Lys Ser  Leu Lys Arg Ala Glu  Ala Glu Val Tyr Lys  Leu Lys Ala 
    3665                 3670                 3675             


Glu Leu  Arg Asn Asp Ser Leu  Leu Gln Thr Leu Ser  Pro Asp Ser 
    3680                 3685                 3690             


Glu His  Val Thr Leu Lys Arg  Ile Tyr Gly Lys Tyr  Leu Arg Ala 
    3695                 3700                 3705             


Glu Ser  Phe Arg Lys Ala Leu  Ile Tyr Gln Lys Lys  Tyr Leu Leu 
    3710                 3715                 3720             


Leu Leu  Leu Gly Gly Phe Gln  Glu Cys Glu Asp Ala  Thr Leu Ala 
    3725                 3730                 3735             


Leu Leu  Ala Arg Met Gly Gly  Gln Pro Ala Phe Thr  Asp Leu Glu 
    3740                 3745                 3750             


Val Ile  Thr Asn Arg Pro Lys  Gly Phe Thr Arg Phe  Arg Ser Ala 
    3755                 3760                 3765             


Val Arg  Val Ser Ile Ala Ile  Ser Arg Met Lys Phe  Leu Val Arg 
    3770                 3775                 3780             


Arg Trp  His Arg Val Thr Gly  Ser Val Ser Ile Asn  Ile Asn Arg 
    3785                 3790                 3795             


Asp Gly  Phe Gly Leu Asn Gln  Gly Ala Glu Lys Thr  Asp Ser Phe 
    3800                 3805                 3810             


Tyr His  Ser Ser Gly Gly Leu  Glu Leu Tyr Gly Glu  Pro Arg His 
    3815                 3820                 3825             


Thr Thr  Tyr Arg Ser Arg Ser  Asp Leu Asp Tyr Ile  Arg Ser Pro 
    3830                 3835                 3840             


Leu Pro  Phe Gln Asn Arg Tyr  Pro Gly Thr Pro Ala  Asp Phe Asn 
    3845                 3850                 3855             


Pro Gly  Ser Leu Ala Cys Ser  Gln Leu Gln Asn Tyr  Asp Pro Asp 
    3860                 3865                 3870             


Arg Ala  Leu Thr Asp Tyr Ile  Thr Arg Leu Glu Ala  Leu Gln Arg 
    3875                 3880                 3885             


Arg Leu  Gly Thr Ile Gln Ser  Gly Ser Thr Thr Gln  Phe His Ala 
    3890                 3895                 3900             


Gly Met  Arg Arg 
    3905         


<210>  404
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKIP1__Homo_sapiens__NP_001193575

<400>  404

Met Asp Asn Cys Leu Ala Ala Ala Ala Leu Asn Gly Val Asp Arg Arg 
1               5                   10                  15      


Ser Leu Gln Arg Ser Ala Arg Leu Ala Leu Glu Val Leu Glu Arg Ala 
            20                  25                  30          


Lys Arg Arg Ala Val Asp Trp His Ala Leu Glu Arg Pro Lys Gly Cys 
        35                  40                  45              


Met Gly Val Leu Ala Arg Glu Ala Pro His Leu Glu Lys Gln Pro Ala 
    50                  55                  60                  


Ala Gly Pro Gln Arg Val Leu Pro Gly Glu Lys Tyr Tyr Ser Ser Val 
65                  70                  75                  80  


Pro Glu Glu Gly Gly Ala Thr His Val Tyr Arg Tyr His Arg Gly Glu 
                85                  90                  95      


Ser Lys Leu His Met Cys Leu Asp Ile Gly Asn Gly Gln Arg Lys Asp 
            100                 105                 110         


Arg Lys Lys Thr Ser Leu Gly Pro Gly Gly Ser Tyr Gln Ile Ser Glu 
        115                 120                 125             


His Ala Pro Glu Ala Ser Gln Pro Ala Glu Asn Ile Ser Lys Asp Leu 
    130                 135                 140                 


Tyr Ile Glu Val Tyr Pro Gly Thr Tyr Ser Val Thr Val Gly Ser Asn 
145                 150                 155                 160 


Asp Leu Thr Lys Lys Thr His Val Val Ala Val Asp Ser Gly Gln Ser 
                165                 170                 175     


Val Asp Leu Val Phe Pro Val 
            180             


<210>  405
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKIRIN2__Homo_sapiens__NP_060534

<400>  405

Met Ala Cys Gly Ala Thr Leu Lys Arg Thr Leu Asp Phe Asp Pro Leu 
1               5                   10                  15      


Leu Ser Pro Ala Ser Pro Lys Arg Arg Arg Cys Ala Pro Leu Ser Ala 
            20                  25                  30          


Pro Thr Ser Ala Ala Ala Ser Pro Leu Ser Ala Ala Ala Ala Thr Ala 
        35                  40                  45              


Ala Ser Phe Ser Ala Ala Ala Ala Ser Pro Gln Lys Tyr Leu Arg Met 
    50                  55                  60                  


Glu Pro Ser Pro Phe Gly Asp Val Ser Ser Arg Leu Thr Thr Glu Gln 
65                  70                  75                  80  


Ile Leu Tyr Asn Ile Lys Gln Glu Tyr Lys Arg Met Gln Lys Arg Arg 
                85                  90                  95      


His Leu Glu Thr Ser Phe Gln Gln Thr Asp Pro Cys Cys Thr Ser Asp 
            100                 105                 110         


Ala Gln Pro His Ala Phe Leu Leu Ser Gly Pro Ala Ser Pro Gly Thr 
        115                 120                 125             


Ser Ser Ala Ala Ser Ser Pro Leu Lys Lys Glu Gln Pro Leu Phe Thr 
    130                 135                 140                 


Leu Arg Gln Val Gly Met Ile Cys Glu Arg Leu Leu Lys Glu Arg Glu 
145                 150                 155                 160 


Glu Lys Val Arg Glu Glu Tyr Glu Glu Ile Leu Asn Thr Lys Leu Ala 
                165                 170                 175     


Glu Gln Tyr Asp Ala Phe Val Lys Phe Thr His Asp Gln Ile Met Arg 
            180                 185                 190         


Arg Tyr Gly Glu Gln Pro Ala Ser Tyr Val Ser 
        195                 200             


<210>  406
<211>  1439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKNA__Homo_sapiens__NP_110394

<400>  406

Met Ala Ser Ser Glu Thr Glu Ile Arg Trp Ala Glu Pro Gly Leu Gly 
1               5                   10                  15      


Lys Gly Pro Gln Arg Arg Arg Trp Ala Trp Ala Glu Asp Lys Arg Asp 
            20                  25                  30          


Val Asp Arg Ser Ser Ser Gln Ser Trp Glu Glu Glu Arg Leu Phe Pro 
        35                  40                  45              


Asn Ala Thr Ser Pro Glu Leu Leu Glu Asp Phe Arg Leu Ala Gln Gln 
    50                  55                  60                  


His Leu Pro Pro Leu Glu Trp Asp Pro His Pro Gln Pro Asp Gly His 
65                  70                  75                  80  


Gln Asp Ser Glu Ser Gly Glu Thr Ser Gly Glu Glu Ala Glu Ala Glu 
                85                  90                  95      


Asp Val Asp Ser Pro Ala Ser Ser His Glu Pro Leu Ala Trp Leu Pro 
            100                 105                 110         


Gln Gln Gly Arg Gln Leu Asp Met Thr Glu Glu Glu Pro Asp Gly Thr 
        115                 120                 125             


Leu Gly Ser Leu Glu Val Glu Glu Ala Gly Glu Ser Ser Ser Arg Leu 
    130                 135                 140                 


Gly Tyr Glu Ala Gly Leu Ser Leu Glu Gly His Gly Asn Thr Ser Pro 
145                 150                 155                 160 


Met Ala Leu Gly His Gly Gln Ala Arg Gly Trp Val Ala Ser Gly Glu 
                165                 170                 175     


Gln Ala Ser Gly Asp Lys Leu Ser Glu His Ser Glu Val Asn Pro Ser 
            180                 185                 190         


Val Glu Leu Ser Pro Ala Arg Ser Trp Ser Ser Gly Thr Val Ser Leu 
        195                 200                 205             


Asp His Pro Ser Asp Ser Leu Asp Ser Thr Trp Glu Gly Glu Thr Asp 
    210                 215                 220                 


Gly Pro Gln Pro Thr Ala Leu Ala Glu Thr Leu Pro Glu Gly Pro Ser 
225                 230                 235                 240 


His His Leu Leu Ser Pro Asp Gly Arg Thr Gly Gly Ser Val Ala Arg 
                245                 250                 255     


Ala Thr Pro Met Glu Phe Gln Asp Ser Ser Ala Pro Pro Ala Gln Ser 
            260                 265                 270         


Pro Gln His Ala Thr Asp Arg Trp Arg Arg Glu Thr Thr Arg Phe Phe 
        275                 280                 285             


Cys Pro Gln Pro Lys Glu His Ile Trp Lys Gln Thr Lys Thr Ser Pro 
    290                 295                 300                 


Lys Pro Leu Pro Ser Arg Phe Ile Gly Ser Ile Ser Pro Leu Asn Pro 
305                 310                 315                 320 


Gln Pro Arg Pro Thr Arg Gln Gly Arg Pro Leu Pro Arg Gln Gly Ala 
                325                 330                 335     


Thr Leu Ala Gly Arg Ser Ser Ser Asn Ala Pro Lys Tyr Gly Arg Gly 
            340                 345                 350         


Gln Leu Asn Tyr Pro Leu Pro Asp Phe Ser Lys Val Gly Pro Arg Val 
        355                 360                 365             


Arg Phe Pro Lys Asp Glu Ser Tyr Arg Pro Pro Lys Ser Arg Ser His 
    370                 375                 380                 


Asn Arg Lys Pro Gln Ala Pro Ala Arg Pro Leu Ile Phe Lys Ser Pro 
385                 390                 395                 400 


Ala Glu Ile Val Gln Glu Val Leu Leu Ser Ser Gly Glu Ala Ala Leu 
                405                 410                 415     


Ala Lys Asp Thr Pro Pro Ala His Pro Ile Thr Arg Val Pro Gln Glu 
            420                 425                 430         


Phe Gln Thr Pro Glu Gln Ala Thr Glu Leu Val His Gln Leu Gln Glu 
        435                 440                 445             


Asp Tyr His Arg Leu Leu Thr Lys Tyr Ala Glu Ala Glu Asn Thr Ile 
    450                 455                 460                 


Asp Gln Leu Arg Leu Gly Ala Lys Val Asn Leu Phe Ser Asp Pro Pro 
465                 470                 475                 480 


Gln Pro Asn His Ser Ile His Thr Gly Met Val Pro Gln Gly Thr Lys 
                485                 490                 495     


Val Leu Ser Phe Thr Ile Pro Gln Pro Arg Ser Ala Glu Trp Trp Pro 
            500                 505                 510         


Gly Pro Ala Glu Asp Pro Gln Ala Ser Ala Ala Ser Gly Trp Pro Ser 
        515                 520                 525             


Ala Arg Gly Asp Leu Ser Pro Ser Ser Leu Thr Ser Met Pro Thr Leu 
    530                 535                 540                 


Gly Trp Leu Pro Glu Asn Arg Asp Ile Ser Glu Asp Gln Ser Ser Ala 
545                 550                 555                 560 


Glu Gln Thr Gln Ala Leu Ala Ser Gln Ala Ser Gln Phe Leu Ala Lys 
                565                 570                 575     


Val Glu Ser Phe Glu Arg Leu Ile Gln Ala Gly Arg Leu Met Pro Gln 
            580                 585                 590         


Asp Gln Val Lys Gly Phe Gln Arg Leu Lys Ala Ala His Ala Ala Leu 
        595                 600                 605             


Glu Glu Glu Tyr Leu Lys Ala Cys Arg Glu Gln His Pro Ala Gln Pro 
    610                 615                 620                 


Leu Ala Gly Ser Lys Gly Thr Pro Gly Arg Phe Asp Pro Arg Arg Glu 
625                 630                 635                 640 


Leu Glu Ala Glu Ile Tyr Arg Leu Gly Ser Cys Leu Glu Glu Leu Lys 
                645                 650                 655     


Glu His Ile Asp Gln Thr Gln Gln Glu Pro Glu Pro Pro Gly Ser Asp 
            660                 665                 670         


Ser Ala Leu Asp Ser Thr Pro Ala Leu Pro Cys Leu His Gln Pro Thr 
        675                 680                 685             


His Leu Pro Ala Pro Ser Gly Gln Ala Pro Met Pro Ala Ile Lys Thr 
    690                 695                 700                 


Ser Cys Pro Glu Pro Ala Thr Thr Thr Ala Ala Ala Ser Thr Gly Pro 
705                 710                 715                 720 


Cys Pro Leu His Val Asn Val Glu Val Ser Ser Gly Asn Ser Glu Val 
                725                 730                 735     


Glu Asp Arg Pro Gln Asp Pro Leu Ala Arg Leu Arg His Lys Glu Leu 
            740                 745                 750         


Gln Met Glu Gln Val Tyr His Gly Leu Met Glu Arg Tyr Leu Ser Val 
        755                 760                 765             


Lys Ser Leu Pro Glu Ala Met Arg Met Glu Glu Glu Glu Glu Gly Glu 
    770                 775                 780                 


Glu Glu Glu Glu Glu Glu Gly Gly Gly Asp Ser Leu Glu Val Asp Gly 
785                 790                 795                 800 


Val Ala Ala Thr Pro Gly Lys Ala Glu Ala Thr Arg Val Leu Pro Arg 
                805                 810                 815     


Gln Cys Pro Val Gln Ala Glu Lys Ser His Gly Ala Pro Leu Glu Glu 
            820                 825                 830         


Ala Thr Glu Lys Met Val Ser Met Lys Pro Pro Gly Phe Gln Ala Ser 
        835                 840                 845             


Leu Ala Arg Asp Gly His Met Ser Gly Leu Gly Lys Ala Glu Ala Ala 
    850                 855                 860                 


Pro Pro Gly Pro Gly Val Pro Pro His Pro Pro Gly Thr Lys Ser Ala 
865                 870                 875                 880 


Ala Ser His Gln Ser Ser Met Thr Ser Leu Glu Gly Ser Gly Ile Ser 
                885                 890                 895     


Glu Arg Leu Pro Gln Lys Pro Leu His Arg Gly Gly Gly Pro His Leu 
            900                 905                 910         


Glu Glu Thr Trp Met Ala Ser Pro Glu Thr Asp Ser Gly Phe Val Gly 
        915                 920                 925             


Ser Glu Thr Ser Arg Val Ser Pro Leu Thr Gln Thr Pro Glu His Arg 
    930                 935                 940                 


Leu Ser His Ile Ser Thr Ala Gly Thr Leu Ala Gln Pro Phe Ala Ala 
945                 950                 955                 960 


Ser Val Pro Arg Asp Gly Ala Ser Tyr Pro Lys Ala Arg Gly Ser Leu 
                965                 970                 975     


Ile Pro Arg Arg Ala Thr Glu Pro Ser Thr Pro Arg Ser Gln Ala Gln 
            980                 985                 990         


Arg Tyr Leu Ser Ser Pro Ser Gly  Pro Leu Arg Gln Arg  Ala Pro Asn 
        995                 1000                 1005             


Phe Ser  Leu Glu Arg Thr Leu  Ala Ala Glu Met Ala  Val Pro Gly 
    1010                 1015                 1020             


Ser Glu  Phe Glu Gly His Lys  Arg Ile Ser Glu Gln  Pro Leu Pro 
    1025                 1030                 1035             


Asn Lys  Thr Ile Ser Pro Pro  Pro Ala Pro Ala Pro  Ala Ala Ala 
    1040                 1045                 1050             


Pro Leu  Pro Cys Gly Pro Thr  Glu Thr Ile Pro Ser  Phe Leu Leu 
    1055                 1060                 1065             


Thr Arg  Ala Gly Arg Asp Gln  Ala Ile Cys Glu Leu  Gln Glu Glu 
    1070                 1075                 1080             


Val Ser  Arg Leu Arg Leu Arg  Leu Glu Asp Ser Leu  His Gln Pro 
    1085                 1090                 1095             


Leu Gln  Gly Ser Pro Thr Arg  Pro Ala Ser Ala Phe  Asp Arg Pro 
    1100                 1105                 1110             


Ala Arg  Thr Arg Gly Arg Pro  Ala Asp Ser Pro Ala  Thr Trp Gly 
    1115                 1120                 1125             


Ser His  Tyr Gly Ser Lys Ser  Thr Glu Arg Leu Pro  Gly Glu Pro 
    1130                 1135                 1140             


Arg Gly  Glu Glu Gln Ile Val  Pro Pro Gly Arg Gln  Arg Ala Arg 
    1145                 1150                 1155             


Ser Ser  Ser Val Pro Arg Glu  Val Leu Arg Leu Ser  Leu Ser Ser 
    1160                 1165                 1170             


Glu Ser  Glu Leu Pro Ser Leu  Pro Leu Phe Ser Glu  Lys Ser Lys 
    1175                 1180                 1185             


Thr Thr  Lys Asp Ser Pro Gln  Ala Ala Arg Asp Gly  Lys Arg Gly 
    1190                 1195                 1200             


Val Gly  Ser Ala Gly Trp Pro  Asp Arg Val Thr Phe  Arg Gly Gln 
    1205                 1210                 1215             


Tyr Thr  Gly His Glu Tyr His  Val Leu Ser Pro Lys  Ala Val Pro 
    1220                 1225                 1230             


Lys Gly  Asn Gly Thr Val Ser  Cys Pro His Cys Arg  Pro Ile Arg 
    1235                 1240                 1245             


Thr Gln  Asp Ala Gly Gly Ala  Val Thr Gly Asp Pro  Leu Gly Pro 
    1250                 1255                 1260             


Pro Pro  Ala Asp Thr Leu Gln  Cys Pro Leu Cys Gly  Gln Val Gly 
    1265                 1270                 1275             


Ser Pro  Pro Glu Ala Asp Gly  Pro Gly Ser Ala Thr  Ser Gly Ala 
    1280                 1285                 1290             


Glu Lys  Ala Thr Thr Arg Arg  Lys Ala Ser Ser Thr  Pro Ser Pro 
    1295                 1300                 1305             


Lys Gln  Arg Ser Lys Gln Ala  Gly Ser Ser Pro Arg  Pro Pro Pro 
    1310                 1315                 1320             


Gly Leu  Trp Tyr Leu Ala Thr  Ala Pro Pro Ala Pro  Ala Pro Pro 
    1325                 1330                 1335             


Ala Phe  Ala Tyr Ile Ser Ser  Val Pro Ile Met Pro  Tyr Pro Pro 
    1340                 1345                 1350             


Ala Ala  Val Tyr Tyr Ala Pro  Ala Gly Pro Thr Ser  Ala Gln Pro 
    1355                 1360                 1365             


Ala Ala  Lys Trp Pro Pro Thr  Ala Ser Pro Pro Pro  Ala Arg Arg 
    1370                 1375                 1380             


His Arg  His Ser Ile Gln Leu  Asp Leu Gly Asp Leu  Glu Glu Leu 
    1385                 1390                 1395             


Asn Lys  Ala Leu Ser Arg Ala  Val Gln Ala Ala Glu  Ser Val Arg 
    1400                 1405                 1410             


Ser Thr  Thr Arg Gln Met Arg  Ser Ser Leu Ser Ala  Asp Leu Arg 
    1415                 1420                 1425             


Gln Ala  His Ser Leu Arg Gly  Ser Cys Leu Phe 
    1430                 1435                 


<210>  407
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1B10__Homo_sapiens__NP_064695

<400>  407

Met Ala Thr Phe Val Glu Leu Ser Thr Lys Ala Lys Met Pro Ile Val 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Leu Gly Lys Val Lys Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Ala Gly Tyr Arg His Ile Asp Cys Ala Tyr Val 
        35                  40                  45              


Tyr Gln Asn Glu His Glu Val Gly Glu Ala Ile Gln Glu Lys Ile Gln 
    50                  55                  60                  


Glu Lys Ala Val Lys Arg Glu Asp Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Pro Thr Phe Phe Glu Arg Pro Leu Val Arg Lys Ala Phe Glu Lys Thr 
                85                  90                  95      


Leu Lys Asp Leu Lys Leu Ser Tyr Leu Asp Val Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Gln Gly Phe Lys Ser Gly Asp Asp Leu Phe Pro Lys Asp Asp Lys 
        115                 120                 125             


Gly Asn Ala Ile Gly Gly Lys Ala Thr Phe Leu Asp Ala Trp Glu Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Leu Gly Val Ser 
145                 150                 155                 160 


Asn Phe Ser His Phe Gln Ile Glu Lys Leu Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Val Thr Asn Gln Val Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys His Ser Lys Gly Ile Thr Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Lys Ile Lys Glu Ile Ala Ala Lys 
225                 230                 235                 240 


His Lys Lys Thr Ala Ala Gln Val Leu Ile Arg Phe His Ile Gln Arg 
                245                 250                 255     


Asn Val Ile Val Ile Pro Lys Ser Val Thr Pro Ala Arg Ile Val Glu 
            260                 265                 270         


Asn Ile Gln Val Phe Asp Phe Lys Leu Ser Asp Glu Glu Met Ala Thr 
        275                 280                 285             


Ile Leu Ser Phe Asn Arg Asn Trp Arg Ala Cys Asn Val Leu Gln Ser 
    290                 295                 300                 


Ser His Leu Glu Asp Tyr Pro Phe Asn Ala Glu Tyr 
305                 310                 315     


<210>  408
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1B1__Homo_sapiens__NP_001619

<400>  408

Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu 
1               5                   10                  15      


Gly Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val 
            20                  25                  30          


Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val 
        35                  40                  45              


Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg 
    50                  55                  60                  


Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp 
65                  70                  75                  80  


Cys Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr 
                85                  90                  95      


Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp 
            100                 105                 110         


Pro Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser 
        115                 120                 125             


Gly Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Trp Ala Ala 
    130                 135                 140                 


Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser 
145                 150                 155                 160 


Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu 
                165                 170                 175     


Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr 
            180                 185                 190         


Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr 
        195                 200                 205             


Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu 
    210                 215                 220                 


Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys 
225                 230                 235                 240 


His Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg 
                245                 250                 255     


Asn Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu 
            260                 265                 270         


Asn Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr 
        275                 280                 285             


Leu Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys 
    290                 295                 300                 


Thr Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe 
305                 310                 315     


<210>  409
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1C1__Homo_sapiens__NP_001344

<400>  409

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val 
        115                 120                 125             


Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu 
    210                 215                 220                 


Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg 
    290                 295                 300                 


Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  410
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1C2__Homo_sapiens__NP_001128713

<400>  410

Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser 
            20                  25                  30          


Lys Ala Leu Glu Ala Val Lys Leu Ala Ile Glu Ala Gly Phe His His 
        35                  40                  45              


Ile Asp Ser Ala His Val Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Ser Asn Ser His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Glu Asp Ile Gly Ile 
        115                 120                 125             


Leu Thr Trp Lys Lys Ser Pro Lys His Asn Ser 
    130                 135                 


<210>  411
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1C3__Homo_sapiens__NP_001240837

<400>  411

Met Asp Ser Lys His Gln Cys Leu Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Ser 
            20                  25                  30          


Lys Ala Leu Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 
        115                 120                 125             


Ser Pro Thr Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu 
    130                 135                 140                 


Cys Thr Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp 
    210                 215                 220                 


Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His 
    290                 295                 300                 


Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  412
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1C4__Homo_sapiens__NP_001809

<400>  412

Met Asp Pro Lys Tyr Gln Arg Val Glu Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Asn 
            20                  25                  30          


Arg Ala Val Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala Tyr Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Cys Thr Phe Phe Gln Pro Gln Met Val Gln 
                85                  90                  95      


Pro Ala Leu Glu Ser Ser Leu Lys Lys Leu Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Leu His Phe Pro Met Ala Leu Lys Pro Gly Glu Thr Pro 
        115                 120                 125             


Leu Pro Lys Asp Glu Asn Gly Lys Val Ile Phe Asp Thr Val Asp Leu 
    130                 135                 140                 


Ser Ala Thr Trp Glu Val Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Cys Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Leu Asn Gln Ser Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala His Ser Ala Leu Gly Thr Gln Arg His 
    210                 215                 220                 


Lys Leu Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Glu Asn Ile Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ser Glu Asp Met Lys Val Leu Asp Gly Leu Asn Arg Asn Tyr Arg 
    290                 295                 300                 


Tyr Val Val Met Asp Phe Leu Met Asp His Pro Asp Tyr Pro Phe Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  413
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1D1__Homo_sapiens__NP_001177835

<400>  413

Met Asp Leu Ser Ala Ala Ser His Arg Ile Pro Leu Ser Asp Gly Asn 
1               5                   10                  15      


Ser Ile Pro Ile Ile Gly Leu Gly Thr Tyr Ser Glu Pro Lys Ser Thr 
            20                  25                  30          


Pro Lys Gly Ala Cys Ala Thr Ser Val Lys Val Ala Ile Asp Thr Gly 
        35                  40                  45              


Tyr Arg His Ile Asp Gly Ala Tyr Ile Tyr Gln Asn Glu His Glu Val 
    50                  55                  60                  


Gly Glu Ala Ile Arg Glu Lys Ile Ala Glu Gly Lys Val Arg Arg Glu 
65                  70                  75                  80  


Asp Ile Phe Tyr Cys Gly Lys Leu Trp Ala Thr Asn His Val Pro Glu 
                85                  90                  95      


Met Val Arg Pro Thr Leu Glu Arg Thr Leu Arg Val Leu Gln Leu Asp 
            100                 105                 110         


Tyr Val Asp Leu Tyr Ile Ile Glu Val Pro Met Ala Phe Lys Pro Gly 
        115                 120                 125             


Asp Glu Ile Tyr Pro Arg Asp Glu Asn Gly Lys Trp Leu Tyr His Lys 
    130                 135                 140                 


Ser Asn Leu Cys Ala Thr Trp Glu Val Glu Cys His Pro Tyr Phe Thr 
145                 150                 155                 160 


Gln Pro Lys Leu Leu Lys Phe Cys Gln Gln His Asp Ile Val Ile Thr 
                165                 170                 175     


Ala Tyr Ser Pro Leu Gly Thr Ser Arg Asn Pro Ile Trp Val Asn Val 
            180                 185                 190         


Ser Ser Pro Pro Leu Leu Lys Asp Ala Leu Leu Asn Ser Leu Gly Lys 
        195                 200                 205             


Arg Tyr Asn Lys Thr Ala Ala Gln Ile Val Leu Arg Phe Asn Ile Gln 
    210                 215                 220                 


Arg Gly Val Val Val Ile Pro Lys Ser Phe Asn Leu Glu Arg Ile Lys 
225                 230                 235                 240 


Glu Asn Phe Gln Ile Phe Asp Phe Ser Leu Thr Glu Glu Glu Met Lys 
                245                 250                 255     


Asp Ile Glu Ala Leu Asn Lys Asn Val Arg Phe Val Glu Leu Leu Met 
            260                 265                 270         


Trp Arg Asp His Pro Glu Tyr Pro Phe His Asp Glu Tyr 
        275                 280                 285 


<210>  414
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR1E2__Homo_sapiens__NP_001035267

<400>  414

Met Gly Asp Ile Pro Ala Val Gly Leu Ser Ser Trp Lys Ala Ser Pro 
1               5                   10                  15      


Gly Lys Val Thr Glu Ala Val Lys Glu Ala Ile Asp Ala Gly Tyr Arg 
            20                  25                  30          


His Phe Asp Cys Ala Tyr Phe Tyr His Asn Glu Arg Glu Val Gly Ala 
        35                  40                  45              


Gly Ile Arg Cys Lys Ile Lys Glu Gly Ala Val Arg Arg Glu Asp Leu 
    50                  55                  60                  


Phe Ile Ala Thr Lys Leu Trp Cys Thr Cys His Lys Lys Ser Leu Val 
65                  70                  75                  80  


Glu Thr Ala Cys Arg Lys Ser Leu Lys Ala Leu Lys Leu Asn Tyr Leu 
                85                  90                  95      


Asp Leu Tyr Leu Ile His Trp Pro Met Gly Phe Lys Pro Pro His Pro 
            100                 105                 110         


Glu Trp Ile Met Ser Cys Ser Glu Leu Ser Phe Cys Leu Ser His Pro 
        115                 120                 125             


Arg Val Gln Asp Leu Pro Leu Asp Glu Ser Asn Met Val Ile Pro Ser 
    130                 135                 140                 


Asp Thr Asp Phe Leu Asp Thr Trp Glu Ala Met Glu Asp Leu Val Ile 
145                 150                 155                 160 


Thr Gly Leu Val Lys Asn Ile Gly Val Ser Asn Phe Asn His Glu Gln 
                165                 170                 175     


Leu Glu Arg Leu Leu Asn Lys Pro Gly Leu Arg Phe Lys Pro Leu Thr 
            180                 185                 190         


Asn Gln Ile Glu Cys His Pro Tyr Leu Thr Gln Lys Asn Leu Ile Ser 
        195                 200                 205             


Phe Cys Gln Ser Arg Asp Val Ser Val Thr Ala Tyr Arg Pro Leu Gly 
    210                 215                 220                 


Gly Ser Cys Glu Gly Val Asp Leu Ile Asp Asn Pro Val Ile Lys Arg 
225                 230                 235                 240 


Ile Ala Lys Glu His Gly Lys Ser Pro Ala Gln Ile Leu Ile Arg Phe 
                245                 250                 255     


Gln Ile Gln Arg Asn Val Ile Val Ile Pro Gly Ser Ile Thr Pro Ser 
            260                 265                 270         


His Ile Lys Glu Asn Ile Gln Val Phe Asp Phe Glu Leu Thr Gln His 
        275                 280                 285             


Asp Met Asp Asn Ile Leu Ser Leu Asn Arg Asn Leu Arg Leu Ala Met 
    290                 295                 300                 


Phe Pro Ile Thr Lys Asn His Lys Asp Tyr Pro Phe His Ile Glu Tyr 
305                 310                 315                 320 


<210>  415
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKR7A3__Homo_sapiens__XP_011539349

<400>  415

Met Ser Arg Gln Leu Ser Arg Ala Arg Pro Ala Thr Val Leu Gly Ala 
1               5                   10                  15      


Met Glu Met Gly Arg Arg Met Asp Ala Pro Thr Ser Ala Ala Val Thr 
            20                  25                  30          


Arg Ala Phe Leu Glu Arg Gly His Thr Glu Ile Asp Thr Ala Phe Val 
        35                  40                  45              


Tyr Ser Glu Gly Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Arg 
    50                  55                  60                  


Leu Gly Gly Ser Asp Cys Arg Val Lys Ile Asp Thr Lys Ala Ile Pro 
65                  70                  75                  80  


Leu Phe Gly Asn Ser Leu Lys Pro Asp Ser Leu Arg Phe Gln Leu Glu 
                85                  90                  95      


Thr Ser Leu Lys Arg Leu Gln Cys Pro Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


His Met Pro Asp His Ser Thr Pro Val Glu Glu Thr Leu Arg Ala Cys 
        115                 120                 125             


His Gln Leu His Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn 
    130                 135                 140                 


Tyr Ala Ala Trp Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn 
145                 150                 155                 160 


Gly Trp Ile Leu Pro Thr Val Tyr Gln Gly Ala Cys 
                165                 170         


<210>  416
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKT1__Homo_sapiens__NP_001014431

<400>  416

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  417
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKT1S1__Homo_sapiens__NP_001092103

<400>  417

Met Ala Ser Gly Arg Pro Glu Glu Leu Trp Glu Ala Val Val Gly Ala 
1               5                   10                  15      


Ala Glu Arg Phe Arg Ala Arg Thr Gly Thr Glu Leu Val Leu Leu Thr 
            20                  25                  30          


Ala Ala Pro Pro Pro Pro Pro Arg Pro Gly Pro Cys Ala Tyr Ala Ala 
        35                  40                  45              


His Gly Arg Gly Ala Leu Ala Glu Ala Ala Arg Arg Cys Leu His Asp 
    50                  55                  60                  


Ile Ala Leu Ala His Arg Ala Ala Thr Ala Ala Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Gln Pro Pro Ser Pro Thr Pro Ser Pro Pro Arg Pro 
                85                  90                  95      


Thr Leu Ala Arg Glu Asp Asn Glu Glu Asp Glu Asp Glu Pro Thr Glu 
            100                 105                 110         


Thr Glu Thr Ser Gly Glu Gln Leu Gly Ile Ser Asp Asn Gly Gly Leu 
        115                 120                 125             


Phe Val Met Asp Glu Asp Ala Thr Leu Gln Asp Leu Pro Pro Phe Cys 
    130                 135                 140                 


Glu Ser Asp Pro Glu Ser Thr Asp Asp Gly Ser Leu Ser Glu Glu Thr 
145                 150                 155                 160 


Pro Ala Gly Pro Pro Thr Cys Ser Val Pro Pro Ala Ser Ala Leu Pro 
                165                 170                 175     


Thr Gln Gln Tyr Ala Lys Ser Leu Pro Val Ser Val Pro Val Trp Gly 
            180                 185                 190         


Phe Lys Glu Lys Arg Thr Glu Ala Arg Ser Ser Asp Glu Glu Asn Gly 
        195                 200                 205             


Pro Pro Ser Ser Pro Asp Leu Asp Arg Ile Ala Ala Ser Met Arg Ala 
    210                 215                 220                 


Leu Val Leu Arg Glu Ala Glu Asp Thr Gln Val Phe Gly Asp Leu Pro 
225                 230                 235                 240 


Arg Pro Arg Leu Asn Thr Ser Asp Phe Gln Lys Leu Lys Arg Lys Tyr 
                245                 250                 255     


<210>  418
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKT2__Homo_sapiens__NP_001229957

<400>  418

Met Lys Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu 
1               5                   10                  15      


Gln Trp Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp 
            20                  25                  30          


Glu Arg Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu 
        35                  40                  45              


Lys Gln Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser 
    50                  55                  60                  


Pro Ser Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys 
65                  70                  75                  80  


Ala Arg Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu 
                85                  90                  95      


Gly Lys Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr 
            100                 105                 110         


Gly Arg Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala 
        115                 120                 125             


Lys Asp Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn 
    130                 135                 140                 


Thr Arg His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His 
145                 150                 155                 160 


Asp Arg Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe 
                165                 170                 175     


Phe His Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe 
            180                 185                 190         


Tyr Gly Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp 
        195                 200                 205             


Val Val Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp 
    210                 215                 220                 


Gly His Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser 
225                 230                 235                 240 


Asp Gly Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala 
                245                 250                 255     


Pro Glu Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp 
            260                 265                 270         


Gly Leu Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe 
        275                 280                 285             


Tyr Asn Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu 
    290                 295                 300                 


Ile Arg Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala 
305                 310                 315                 320 


Gly Leu Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser 
                325                 330                 335     


Asp Ala Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp 
            340                 345                 350         


Gln Asp Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val 
        355                 360                 365             


Thr Ser Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln 
    370                 375                 380                 


Ser Ile Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu 
385                 390                 395                 400 


Glu Leu Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser 
                405                 410                 415     


Ile Arg Glu 
            


<210>  419
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKT3__Homo_sapiens__NP_001193658

<400>  419

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Cys Gln Gln Ser Asp Cys Gly Met Leu Gly Asn Trp Lys 
    450                 455                 460                 


Lys 
465 


<210>  420
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKTIP__Homo_sapiens__NP_071921

<400>  420

Met Asn Pro Phe Trp Ser Met Ser Thr Ser Ser Val Arg Lys Arg Ser 
1               5                   10                  15      


Glu Gly Glu Glu Lys Thr Leu Thr Gly Asp Val Lys Thr Ser Pro Pro 
            20                  25                  30          


Arg Thr Ala Pro Lys Lys Gln Leu Pro Ser Ile Pro Lys Asn Ala Leu 
        35                  40                  45              


Pro Ile Thr Lys Pro Thr Ser Pro Ala Pro Ala Ala Gln Ser Thr Asn 
    50                  55                  60                  


Gly Thr His Ala Ser Tyr Gly Pro Phe Tyr Leu Glu Tyr Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Phe Thr Leu Val Val Lys Gln Lys Leu Pro Gly Val Tyr Val 
                85                  90                  95      


Gln Pro Ser Tyr Arg Ser Ala Leu Met Trp Phe Gly Val Ile Phe Ile 
            100                 105                 110         


Arg His Gly Leu Tyr Gln Asp Gly Val Phe Lys Phe Thr Val Tyr Ile 
        115                 120                 125             


Pro Asp Asn Tyr Pro Asp Gly Asp Cys Pro Arg Leu Val Phe Asp Ile 
    130                 135                 140                 


Pro Val Phe His Pro Leu Val Asp Pro Thr Ser Gly Glu Leu Asp Val 
145                 150                 155                 160 


Lys Arg Ala Phe Ala Lys Trp Arg Arg Asn His Asn His Ile Trp Gln 
                165                 170                 175     


Val Leu Met Tyr Ala Arg Arg Val Phe Tyr Lys Ile Asp Thr Ala Ser 
            180                 185                 190         


Pro Leu Asn Pro Glu Ala Ala Val Leu Tyr Glu Lys Asp Ile Gln Leu 
        195                 200                 205             


Phe Lys Ser Lys Val Val Asp Ser Val Lys Val Cys Thr Ala Arg Leu 
    210                 215                 220                 


Phe Asp Gln Pro Lys Ile Glu Asp Pro Tyr Ala Ile Ser Phe Ser Pro 
225                 230                 235                 240 


Trp Asn Pro Ser Val His Asp Glu Ala Arg Glu Lys Met Leu Thr Gln 
                245                 250                 255     


Lys Lys Pro Glu Glu Gln His Asn Lys Ser Val His Val Ala Gly Leu 
            260                 265                 270         


Ser Trp Val Lys Pro Gly Ser Val Gln Pro Phe Ser Lys Glu Glu Lys 
        275                 280                 285             


Thr Val Ala Thr 
    290         


<210>  421
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALAD__Homo_sapiens__NP_000022

<400>  421

Met Gln Pro Gln Ser Val Leu His Ser Gly Tyr Phe His Pro Leu Leu 
1               5                   10                  15      


Arg Ala Trp Gln Thr Ala Thr Thr Thr Leu Asn Ala Ser Asn Leu Ile 
            20                  25                  30          


Tyr Pro Ile Phe Val Thr Asp Val Pro Asp Asp Ile Gln Pro Ile Thr 
        35                  40                  45              


Ser Leu Pro Gly Val Ala Arg Tyr Gly Val Lys Arg Leu Glu Glu Met 
    50                  55                  60                  


Leu Arg Pro Leu Val Glu Glu Gly Leu Arg Cys Val Leu Ile Phe Gly 
65                  70                  75                  80  


Val Pro Ser Arg Val Pro Lys Asp Glu Arg Gly Ser Ala Ala Asp Ser 
                85                  90                  95      


Glu Glu Ser Pro Ala Ile Glu Ala Ile His Leu Leu Arg Lys Thr Phe 
            100                 105                 110         


Pro Asn Leu Leu Val Ala Cys Asp Val Cys Leu Cys Pro Tyr Thr Ser 
        115                 120                 125             


His Gly His Cys Gly Leu Leu Ser Glu Asn Gly Ala Phe Arg Ala Glu 
    130                 135                 140                 


Glu Ser Arg Gln Arg Leu Ala Glu Val Ala Leu Ala Tyr Ala Lys Ala 
145                 150                 155                 160 


Gly Cys Gln Val Val Ala Pro Ser Asp Met Met Asp Gly Arg Val Glu 
                165                 170                 175     


Ala Ile Lys Glu Ala Leu Met Ala His Gly Leu Gly Asn Arg Val Ser 
            180                 185                 190         


Val Met Ser Tyr Ser Ala Lys Phe Ala Ser Cys Phe Tyr Gly Pro Phe 
        195                 200                 205             


Arg Asp Ala Ala Lys Ser Ser Pro Ala Phe Gly Asp Arg Arg Cys Tyr 
    210                 215                 220                 


Gln Leu Pro Pro Gly Ala Arg Gly Leu Ala Leu Arg Ala Val Asp Arg 
225                 230                 235                 240 


Asp Val Arg Glu Gly Ala Asp Met Leu Met Val Lys Pro Gly Met Pro 
                245                 250                 255     


Tyr Leu Asp Ile Val Arg Glu Val Lys Asp Lys His Pro Asp Leu Pro 
            260                 265                 270         


Leu Ala Val Tyr His Val Ser Gly Glu Phe Ala Met Leu Trp His Gly 
        275                 280                 285             


Ala Gln Ala Gly Ala Phe Asp Leu Lys Ala Ala Val Leu Glu Ala Met 
    290                 295                 300                 


Thr Ala Phe Arg Arg Ala Gly Ala Asp Ile Ile Ile Thr Tyr Tyr Thr 
305                 310                 315                 320 


Pro Gln Leu Leu Gln Trp Leu Lys Glu Glu 
                325                 330 


<210>  422
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALAS1__Homo_sapiens__NP_001291372

<400>  422

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
1               5                   10                  15      


Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
            20                  25                  30          


Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
        35                  40                  45              


Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
    50                  55                  60                  


Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
65                  70                  75                  80  


Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                85                  90                  95      


Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
            100                 105                 110         


Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
        115                 120                 125             


Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
    130                 135                 140                 


Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
145                 150                 155                 160 


Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                165                 170                 175     


Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
            180                 185                 190         


Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
        195                 200                 205             


Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
    210                 215                 220                 


Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
225                 230                 235                 240 


Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                245                 250                 255     


Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
            260                 265                 270         


His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
        275                 280                 285             


Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
    290                 295                 300                 


Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
305                 310                 315                 320 


Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                325                 330                 335     


Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
            340                 345                 350         


Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
        355                 360                 365             


Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
    370                 375                 380                 


His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
385                 390                 395                 400 


Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                405                 410                 415     


Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
            420                 425                 430         


Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
        435                 440                 445             


Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
    450                 455                 460                 


Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
465                 470                 475                 480 


Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                485                 490                 495     


Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
            500                 505                 510         


Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
        515                 520                 525             


Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
    530                 535                 540                 


Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
545                 550                 555                 560 


Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                565                 570                 575     


His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
            580                 585                 590         


Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
        595                 600                 605             


Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
    610                 615                 620                 


Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
625                 630                 635                 640 


<210>  423
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALAS2__Homo_sapiens__NP_000023

<400>  423

Met Val Thr Ala Ala Met Leu Leu Gln Cys Cys Pro Val Leu Ala Arg 
1               5                   10                  15      


Gly Pro Thr Ser Leu Leu Gly Lys Val Val Lys Thr His Gln Phe Leu 
            20                  25                  30          


Phe Gly Ile Gly Arg Cys Pro Ile Leu Ala Thr Gln Gly Pro Asn Cys 
        35                  40                  45              


Ser Gln Ile His Leu Lys Ala Thr Lys Ala Gly Gly Asp Ser Pro Ser 
    50                  55                  60                  


Trp Ala Lys Gly His Cys Pro Phe Met Leu Ser Glu Leu Gln Asp Gly 
65                  70                  75                  80  


Lys Ser Lys Ile Val Gln Lys Ala Ala Pro Glu Val Gln Glu Asp Val 
                85                  90                  95      


Lys Ala Phe Lys Thr Asp Leu Pro Ser Ser Leu Val Ser Val Ser Leu 
            100                 105                 110         


Arg Lys Pro Phe Ser Gly Pro Gln Glu Gln Glu Gln Ile Ser Gly Lys 
        115                 120                 125             


Val Thr His Leu Ile Gln Asn Asn Met Pro Gly Asn Tyr Val Phe Ser 
    130                 135                 140                 


Tyr Asp Gln Phe Phe Arg Asp Lys Ile Met Glu Lys Lys Gln Asp His 
145                 150                 155                 160 


Thr Tyr Arg Val Phe Lys Thr Val Asn Arg Trp Ala Asp Ala Tyr Pro 
                165                 170                 175     


Phe Ala Gln His Phe Ser Glu Ala Ser Val Ala Ser Lys Asp Val Ser 
            180                 185                 190         


Val Trp Cys Ser Asn Asp Tyr Leu Gly Met Ser Arg His Pro Gln Val 
        195                 200                 205             


Leu Gln Ala Thr Gln Glu Thr Leu Gln Arg His Gly Ala Gly Ala Gly 
    210                 215                 220                 


Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys Phe His Val Glu Leu Glu 
225                 230                 235                 240 


Gln Glu Leu Ala Glu Leu His Gln Lys Asp Ser Ala Leu Leu Phe Ser 
                245                 250                 255     


Ser Cys Phe Val Ala Asn Asp Ser Thr Leu Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


Leu Pro Gly Cys Glu Ile Tyr Ser Asp Ala Gly Asn His Ala Ser Met 
        275                 280                 285             


Ile Gln Gly Ile Arg Asn Ser Gly Ala Ala Lys Phe Val Phe Arg His 
    290                 295                 300                 


Asn Asp Pro Asp His Leu Lys Lys Leu Leu Glu Lys Ser Asn Pro Lys 
305                 310                 315                 320 


Ile Pro Lys Ile Val Ala Phe Glu Thr Val His Ser Met Asp Gly Ala 
                325                 330                 335     


Ile Cys Pro Leu Glu Glu Leu Cys Asp Val Ser His Gln Tyr Gly Ala 
            340                 345                 350         


Leu Thr Phe Val Asp Glu Val His Ala Val Gly Leu Tyr Gly Ser Arg 
        355                 360                 365             


Gly Ala Gly Ile Gly Glu Arg Asp Gly Ile Met His Lys Ile Asp Ile 
    370                 375                 380                 


Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly Cys Val Gly Gly Tyr Ile 
385                 390                 395                 400 


Ala Ser Thr Arg Asp Leu Val Asp Met Val Arg Ser Tyr Ala Ala Gly 
                405                 410                 415     


Phe Ile Phe Thr Thr Ser Leu Pro Pro Met Val Leu Ser Gly Ala Leu 
            420                 425                 430         


Glu Ser Val Arg Leu Leu Lys Gly Glu Glu Gly Gln Ala Leu Arg Arg 
        435                 440                 445             


Ala His Gln Arg Asn Val Lys His Met Arg Gln Leu Leu Met Asp Arg 
    450                 455                 460                 


Gly Leu Pro Val Ile Pro Cys Pro Ser His Ile Ile Pro Ile Arg Val 
465                 470                 475                 480 


Gly Asn Ala Ala Leu Asn Ser Lys Leu Cys Asp Leu Leu Leu Ser Lys 
                485                 490                 495     


His Gly Ile Tyr Val Gln Ala Ile Asn Tyr Pro Thr Val Pro Arg Gly 
            500                 505                 510         


Glu Glu Leu Leu Arg Leu Ala Pro Ser Pro His His Ser Pro Gln Met 
        515                 520                 525             


Met Glu Asp Phe Val Glu Lys Leu Leu Leu Ala Trp Thr Ala Val Gly 
    530                 535                 540                 


Leu Pro Leu Gln Asp Val Ser Val Ala Ala Cys Asn Phe Cys Arg Arg 
545                 550                 555                 560 


Pro Val His Phe Glu Leu Met Ser Glu Trp Glu Arg Ser Tyr Phe Gly 
                565                 570                 575     


Asn Met Gly Pro Gln Tyr Val Thr Thr Tyr Ala 
            580                 585         


<210>  424
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALB__Homo_sapiens__NP_000468

<400>  424

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  425
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALCAM__Homo_sapiens__NP_001230209

<400>  425

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Asn Glu Asn Arg Glu Lys Val Asn Asp Gln 
            500                 505                 510         


Ala Lys Leu Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu 
        515                 520                 525             


Val Ala Gly Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala 
    530                 535                 540                 


Ser Lys His Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys 
545                 550                 555                 560 


Leu Glu Glu Asn Asn His Lys Thr Glu Ala 
                565                 570 


<210>  426
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH16A1__Homo_sapiens__NP_001138868

<400>  426

Met Ala Ala Thr Arg Ala Gly Pro Arg Ala Arg Glu Ile Phe Thr Ser 
1               5                   10                  15      


Leu Glu Tyr Gly Pro Val Pro Glu Ser His Ala Cys Ala Leu Ala Trp 
            20                  25                  30          


Leu Asp Thr Gln Asp Arg Cys Leu Gly His Tyr Val Asn Gly Lys Trp 
        35                  40                  45              


Leu Lys Pro Glu His Arg Asn Ser Val Pro Cys Gln Asp Pro Ile Thr 
    50                  55                  60                  


Gly Glu Asn Leu Ala Ser Cys Leu Gln Ala Gln Ala Glu Asp Val Ala 
65                  70                  75                  80  


Ala Ala Val Glu Ala Ala Arg Met Ala Phe Lys Gly Trp Ser Ala His 
                85                  90                  95      


Pro Gly Val Val Arg Ala Gln His Leu Thr Arg Leu Ala Glu Val Ile 
            100                 105                 110         


Gln Lys His Gln Arg Leu Leu Trp Thr Leu Glu Ser Leu Val Thr Gly 
        115                 120                 125             


Arg Ala Val Arg Glu Val Arg Asp Gly Asp Val Gln Leu Ala Gln Gln 
    130                 135                 140                 


Leu Leu His Tyr His Ala Ile Gln Ala Ser Thr Gln Glu Glu Ala Leu 
145                 150                 155                 160 


Ala Gly Trp Glu Pro Met Gly Val Ile Gly Leu Ile Leu Pro Pro Thr 
                165                 170                 175     


Phe Ser Phe Leu Glu Met Met Trp Arg Ile Cys Pro Ala Leu Ala Val 
            180                 185                 190         


Gly Cys Thr Val Val Ala Leu Val Pro Pro Ala Ser Pro Ala Pro Leu 
        195                 200                 205             


Leu Leu Ala Gln Leu Ala Gly Glu Leu Gly Pro Phe Pro Gly Ile Leu 
    210                 215                 220                 


Asn Val Leu Ser Gly Pro Ala Ser Leu Val Pro Ile Leu Ala Ser Gln 
225                 230                 235                 240 


Pro Gly Ile Arg Lys Val Ala Phe Cys Gly Ala Pro Glu Gly Gly Leu 
                245                 250                 255     


Arg Leu Leu Ile Gln Glu Ser Val Trp Asp Glu Ala Met Arg Arg Leu 
            260                 265                 270         


Gln Glu Arg Met Gly Arg Leu Arg Ser Gly Arg Gly Leu Asp Gly Ala 
        275                 280                 285             


Val Asp Met Gly Ala Arg Gly Ala Ala Ala Cys Asp Leu Val Gln Arg 
    290                 295                 300                 


Phe Val Arg Glu Ala Gln Ser Gln Gly Ala Gln Val Phe Gln Ala Gly 
305                 310                 315                 320 


Asp Val Pro Ser Glu Arg Pro Phe Tyr Pro Pro Thr Leu Val Ser Asn 
                325                 330                 335     


Leu Pro Pro Ala Ser Pro Cys Ala Gln Val Glu Val Pro Trp Pro Val 
            340                 345                 350         


Val Val Ala Ser Pro Phe Arg Thr Ala Lys Glu Ala Leu Leu Val Ala 
        355                 360                 365             


Asn Gly Thr Pro Arg Gly Gly Ser Ala Ser Val Trp Ser Glu Arg Leu 
    370                 375                 380                 


Gly Gln Ala Leu Glu Leu Gly Tyr Gly Leu Gln Val Gly Thr Val Trp 
385                 390                 395                 400 


Ile Asn Ala His Gly Leu Arg Asp Pro Ser Val Pro Thr Gly Gly Cys 
                405                 410                 415     


Lys Glu Ser Gly Cys Ser Trp His Gly Gly Pro Asp Gly Leu Tyr Glu 
            420                 425                 430         


Tyr Leu Arg Pro Ser Gly Thr Pro Ala Arg Leu Ser Cys Leu Ser Lys 
        435                 440                 445             


Asn Leu Asn Tyr Asp Thr Phe Gly Leu Ala Val Pro Ser Thr Leu Pro 
    450                 455                 460                 


Ala Gly Pro Glu Ile Gly Pro Ser Pro Ala Pro Pro Tyr Gly Leu Phe 
465                 470                 475                 480 


Val Gly Gly Arg Phe Gln Ala Pro Gly Ala Arg Ser Ser Arg Pro Ile 
                485                 490                 495     


Arg Asp Ser Ser Gly Asn Leu His Gly Tyr Val Ala Glu Gly Gly Ala 
            500                 505                 510         


Lys Asp Ile Arg Gly Ala Val Glu Ala Ala His Gln Ala Phe Pro Gly 
        515                 520                 525             


Trp Ala Gly Gln Ser Pro Gly Ala Arg Ala Ala Leu Leu Trp Ala Leu 
    530                 535                 540                 


Ala Ala Ala Leu Glu Arg Arg Lys Ser Thr Leu Ala Ser Arg Leu Glu 
545                 550                 555                 560 


Arg Gln Gly Ala Glu Leu Lys Ala Ala Glu Ala Glu Val Glu Leu Ser 
                565                 570                 575     


Ala Arg Arg Leu Arg Ala Trp Gly Ala Arg Val Gln Ala Gln Gly His 
            580                 585                 590         


Thr Leu Gln Val Ala Gly Leu Arg Gly Pro Val Leu Arg Leu Arg Glu 
        595                 600                 605             


Pro Leu Gly Val Leu Ala Val Val Cys Pro Asp Glu Trp Pro Leu Leu 
    610                 615                 620                 


Ala Phe Val Ser Leu Leu Ala Pro Ala Leu Ala Tyr Gly Asn Thr Val 
625                 630                 635                 640 


Val Met Val Pro Ser Ala Ala Cys Pro Leu Leu Ala Leu Glu Val Cys 
                645                 650                 655     


Gln Asp Met Ala Thr Val Phe Pro Ala Gly Leu Ala Asn Val Val Thr 
            660                 665                 670         


Gly Asp Arg Asp His Leu Thr Arg Cys Leu Ala Leu His Gln Asp Val 
        675                 680                 685             


Gln Ala Met Trp Tyr Phe Gly Ser Ala Gln Gly Ser Gln Phe Val Glu 
    690                 695                 700                 


Trp Ala Ser Ala Gly Asn Leu Lys Pro Val Trp Ala Ser Arg Gly Cys 
705                 710                 715                 720 


Pro Arg Ala Trp Asp Gln Glu Ala Glu Gly Ala Gly Pro Glu Leu Gly 
                725                 730                 735     


Leu Arg Val Ala Arg Thr Lys Ala Leu Trp Leu Pro Met Gly Asp 
            740                 745                 750     


<210>  427
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH18A1__Homo_sapiens__NP_001017423

<400>  427

Met Leu Ser Gln Val Tyr Arg Cys Gly Phe Gln Pro Phe Asn Gln His 
1               5                   10                  15      


Leu Leu Pro Trp Val Lys Cys Thr Thr Val Phe Arg Ser His Cys Ile 
            20                  25                  30          


Gln Pro Ser Val Ile Arg His Val Arg Ser Trp Ser Asn Ile Pro Phe 
        35                  40                  45              


Ile Thr Val Pro Leu Ser Arg Thr His Gly Lys Ser Phe Ala His Arg 
    50                  55                  60                  


Ser Glu Leu Lys His Ala Lys Arg Ile Val Val Lys Leu Gly Ser Ala 
65                  70                  75                  80  


Val Val Thr Arg Gly Asp Glu Cys Gly Leu Ala Leu Gly Arg Leu Ala 
                85                  90                  95      


Ser Ile Val Glu Gln Val Ser Val Leu Gln Asn Gln Gly Arg Glu Met 
            100                 105                 110         


Met Leu Val Thr Ser Gly Ala Val Ala Phe Gly Lys Gln Arg Leu Arg 
        115                 120                 125             


His Glu Ile Leu Leu Ser Gln Ser Val Arg Gln Ala Leu His Ser Gly 
    130                 135                 140                 


Gln Asn Gln Leu Lys Glu Met Ala Ile Pro Val Leu Glu Ala Arg Ala 
145                 150                 155                 160 


Cys Ala Ala Ala Gly Gln Ser Gly Leu Met Ala Leu Tyr Glu Ala Met 
                165                 170                 175     


Phe Thr Gln Tyr Ser Ile Cys Ala Ala Gln Ile Leu Val Thr Asn Leu 
            180                 185                 190         


Asp Phe His Asp Glu Gln Lys Arg Arg Asn Leu Asn Gly Thr Leu His 
        195                 200                 205             


Glu Leu Leu Arg Met Asn Ile Val Pro Ile Val Asn Thr Asn Asp Ala 
    210                 215                 220                 


Val Val Pro Pro Ala Glu Pro Asn Ser Asp Leu Gln Gly Val Ile Ser 
225                 230                 235                 240 


Val Lys Asp Asn Asp Ser Leu Ala Ala Arg Leu Ala Val Glu Met Lys 
                245                 250                 255     


Thr Asp Leu Leu Ile Val Leu Ser Asp Val Glu Gly Leu Phe Asp Ser 
            260                 265                 270         


Pro Pro Gly Ser Asp Asp Ala Lys Leu Ile Asp Ile Phe Tyr Pro Gly 
        275                 280                 285             


Asp Gln Gln Ser Val Thr Phe Gly Thr Lys Ser Arg Val Gly Met Gly 
    290                 295                 300                 


Gly Met Glu Ala Lys Val Lys Ala Ala Leu Trp Ala Leu Gln Gly Gly 
305                 310                 315                 320 


Thr Ser Val Val Ile Ala Asn Gly Thr His Pro Lys Val Ser Gly His 
                325                 330                 335     


Val Ile Thr Asp Ile Val Glu Gly Lys Lys Val Gly Thr Phe Phe Ser 
            340                 345                 350         


Glu Val Lys Pro Ala Gly Pro Thr Val Glu Gln Gln Gly Glu Met Ala 
        355                 360                 365             


Arg Ser Gly Gly Arg Met Leu Ala Thr Leu Glu Pro Glu Gln Arg Ala 
    370                 375                 380                 


Glu Ile Ile His His Leu Ala Asp Leu Leu Thr Asp Gln Arg Asp Glu 
385                 390                 395                 400 


Ile Leu Leu Ala Asn Lys Lys Asp Leu Glu Glu Ala Glu Gly Arg Leu 
                405                 410                 415     


Ala Ala Pro Leu Leu Lys Arg Leu Ser Leu Ser Thr Ser Lys Leu Asn 
            420                 425                 430         


Ser Leu Ala Ile Gly Leu Arg Gln Ile Ala Ala Ser Ser Gln Asp Ser 
        435                 440                 445             


Val Gly Arg Val Leu Arg Arg Thr Arg Ile Ala Lys Asn Leu Glu Leu 
    450                 455                 460                 


Glu Gln Val Thr Val Pro Ile Gly Val Leu Leu Val Ile Phe Glu Ser 
465                 470                 475                 480 


Arg Pro Asp Cys Leu Pro Gln Val Ala Ala Leu Ala Ile Ala Ser Gly 
                485                 490                 495     


Asn Gly Leu Leu Leu Lys Gly Gly Lys Glu Ala Ala His Ser Asn Arg 
            500                 505                 510         


Ile Leu His Leu Leu Thr Gln Glu Ala Leu Ser Ile His Gly Val Lys 
        515                 520                 525             


Glu Ala Val Gln Leu Val Asn Thr Arg Glu Glu Val Glu Asp Leu Cys 
    530                 535                 540                 


Arg Leu Asp Lys Met Ile Asp Leu Ile Ile Pro Arg Gly Ser Ser Gln 
545                 550                 555                 560 


Leu Val Arg Asp Ile Gln Lys Ala Ala Lys Gly Ile Pro Val Met Gly 
                565                 570                 575     


His Ser Glu Gly Ile Cys His Met Tyr Val Asp Ser Glu Ala Ser Val 
            580                 585                 590         


Asp Lys Val Thr Arg Leu Val Arg Asp Ser Lys Cys Glu Tyr Pro Ala 
        595                 600                 605             


Ala Cys Asn Ala Leu Glu Thr Leu Leu Ile His Arg Asp Leu Leu Arg 
    610                 615                 620                 


Thr Pro Leu Phe Asp Gln Ile Ile Asp Met Leu Arg Val Glu Gln Val 
625                 630                 635                 640 


Lys Ile His Ala Gly Pro Lys Phe Ala Ser Tyr Leu Thr Phe Ser Pro 
                645                 650                 655     


Ser Glu Val Lys Ser Leu Arg Thr Glu Tyr Gly Asp Leu Glu Leu Cys 
            660                 665                 670         


Ile Glu Val Val Asp Asn Val Gln Asp Ala Ile Asp His Ile His Lys 
        675                 680                 685             


Tyr Gly Ser Ser His Thr Asp Val Ile Val Thr Glu Asp Glu Asn Thr 
    690                 695                 700                 


Ala Glu Phe Phe Leu Gln His Val Asp Ser Ala Cys Val Phe Trp Asn 
705                 710                 715                 720 


Ala Ser Thr Arg Phe Ser Asp Gly Tyr Arg Phe Gly Leu Gly Ala Glu 
                725                 730                 735     


Val Gly Ile Ser Thr Ser Arg Ile His Ala Arg Gly Pro Val Gly Leu 
            740                 745                 750         


Glu Gly Leu Leu Thr Thr Lys Trp Leu Leu Arg Gly Lys Asp His Val 
        755                 760                 765             


Val Ser Asp Phe Ser Glu His Gly Ser Leu Lys Tyr Leu His Glu Asn 
    770                 775                 780                 


Leu Pro Ile Pro Gln Arg Asn Thr Asn 
785                 790             


<210>  428
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH1A1__Homo_sapiens__NP_000680

<400>  428

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  429
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH1A2__Homo_sapiens__NP_001193826

<400>  429

Met Lys Asn Gln Cys Glu Thr Val Trp Leu Lys Ser Pro Ile Lys Leu 
1               5                   10                  15      


Lys Leu Ile Phe Ile Asn Asn Glu Trp Gln Asn Ser Glu Ser Gly Arg 
            20                  25                  30          


Val Phe Pro Val Tyr Asn Pro Ala Thr Gly Glu Gln Val Cys Glu Val 
        35                  40                  45              


Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala Val Gln Ala Ala Arg 
    50                  55                  60                  


Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg Met Asp Ala Ser Glu 
65                  70                  75                  80  


Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu Val Glu Arg Asp Arg 
                85                  90                  95      


Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly Gly Lys Pro Phe Leu 
            100                 105                 110         


Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile Lys Thr Phe Arg Tyr 
        115                 120                 125             


Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met Thr Ile Pro Val Asp 
    130                 135                 140                 


Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro Ile Gly Val Cys Gly 
145                 150                 155                 160 


Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Phe Ala Trp Lys Ile 
                165                 170                 175     


Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val Ile Lys Pro Ala Glu 
            180                 185                 190         


Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala Leu Ile Lys Glu Ala 
        195                 200                 205             


Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro Gly Tyr Gly Pro Thr 
    210                 215                 220                 


Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile Asp Lys Ile Ala Phe 
225                 230                 235                 240 


Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Gln Glu Ala Ala Gly Arg 
                245                 250                 255     


Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn 
            260                 265                 270         


Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala Val Glu Gln Ala His 
        275                 280                 285             


Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Thr Ala Gly Ser Arg 
    290                 295                 300                 


Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe Val Arg Arg Ser Val 
305                 310                 315                 320 


Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro Phe Asp Pro Thr Thr 
                325                 330                 335     


Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr Asn Lys Ile Leu Glu 
            340                 345                 350         


Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys Leu Glu Cys Gly Gly 
        355                 360                 365             


Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu Pro Thr Val Phe Ser 
    370                 375                 380                 


Asn Val Thr Asp Asp Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 


Val Gln Glu Ile Leu Arg Phe Lys Thr Met Asp Glu Val Ile Glu Arg 
                405                 410                 415     


Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala Val Phe Thr Asn Asp 
            420                 425                 430         


Ile Asn Lys Ala Leu Thr Val Ser Ser Ala Met Gln Ala Gly Thr Val 
        435                 440                 445             


Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln Ser Pro Phe Gly Gly 
    450                 455                 460                 


Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly Glu Phe Gly Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Glu Val Lys Thr Val Thr Val Lys Ile Pro Gln Lys Asn 
                485                 490                 495     


Ser 
    


<210>  430
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH1A3__Homo_sapiens__NP_000684

<400>  430

Met Ala Thr Ala Asn Gly Ala Val Glu Asn Gly Gln Pro Asp Arg Lys 
1               5                   10                  15      


Pro Pro Ala Leu Pro Arg Pro Ile Arg Asn Leu Glu Val Lys Phe Thr 
            20                  25                  30          


Lys Ile Phe Ile Asn Asn Glu Trp His Glu Ser Lys Ser Gly Lys Lys 
        35                  40                  45              


Phe Ala Thr Cys Asn Pro Ser Thr Arg Glu Gln Ile Cys Glu Val Glu 
    50                  55                  60                  


Glu Gly Asp Lys Pro Asp Val Asp Lys Ala Val Glu Ala Ala Gln Val 
65                  70                  75                  80  


Ala Phe Gln Arg Gly Ser Pro Trp Arg Arg Leu Asp Ala Leu Ser Arg 
                85                  90                  95      


Gly Arg Leu Leu His Gln Leu Ala Asp Leu Val Glu Arg Asp Arg Ala 
            100                 105                 110         


Thr Leu Ala Ala Leu Glu Thr Met Asp Thr Gly Lys Pro Phe Leu His 
        115                 120                 125             


Ala Phe Phe Ile Asp Leu Glu Gly Cys Ile Arg Thr Leu Arg Tyr Phe 
    130                 135                 140                 


Ala Gly Trp Ala Asp Lys Ile Gln Gly Lys Thr Ile Pro Thr Asp Asp 
145                 150                 155                 160 


Asn Val Val Cys Phe Thr Arg His Glu Pro Ile Gly Val Cys Gly Ala 
                165                 170                 175     


Ile Thr Pro Trp Asn Phe Pro Leu Leu Met Leu Val Trp Lys Leu Ala 
            180                 185                 190         


Pro Ala Leu Cys Cys Gly Asn Thr Met Val Leu Lys Pro Ala Glu Gln 
        195                 200                 205             


Thr Pro Leu Thr Ala Leu Tyr Leu Gly Ser Leu Ile Lys Glu Ala Gly 
    210                 215                 220                 


Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly Phe Gly Pro Thr Val 
225                 230                 235                 240 


Gly Ala Ala Ile Ser Ser His Pro Gln Ile Asn Lys Ile Ala Phe Thr 
                245                 250                 255     


Gly Ser Thr Glu Val Gly Lys Leu Val Lys Glu Ala Ala Ser Arg Ser 
            260                 265                 270         


Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Asn Pro Cys Ile 
        275                 280                 285             


Val Cys Ala Asp Ala Asp Leu Asp Leu Ala Val Glu Cys Ala His Gln 
    290                 295                 300                 


Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Thr Ala Ala Ser Arg Val 
305                 310                 315                 320 


Phe Val Glu Glu Gln Val Tyr Ser Glu Phe Val Arg Arg Ser Val Glu 
                325                 330                 335     


Tyr Ala Lys Lys Arg Pro Val Gly Asp Pro Phe Asp Val Lys Thr Glu 
            340                 345                 350         


Gln Gly Pro Gln Ile Asp Gln Lys Gln Phe Asp Lys Ile Leu Glu Leu 
        355                 360                 365             


Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu Glu Cys Gly Gly Ser 
    370                 375                 380                 


Ala Met Glu Asp Lys Gly Leu Phe Ile Lys Pro Thr Val Phe Ser Glu 
385                 390                 395                 400 


Val Thr Asp Asn Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro Val 
                405                 410                 415     


Gln Pro Ile Leu Lys Phe Lys Ser Ile Glu Glu Val Ile Lys Arg Ala 
            420                 425                 430         


Asn Ser Thr Asp Tyr Gly Leu Thr Ala Ala Val Phe Thr Lys Asn Leu 
        435                 440                 445             


Asp Lys Ala Leu Lys Leu Ala Ser Ala Leu Glu Ser Gly Thr Val Trp 
    450                 455                 460                 


Ile Asn Cys Tyr Asn Ala Leu Tyr Ala Gln Ala Pro Phe Gly Gly Phe 
465                 470                 475                 480 


Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu Tyr Ala Leu Ala Glu 
                485                 490                 495     


Tyr Thr Glu Val Lys Thr Val Thr Ile Lys Leu Gly Asp Lys Asn Pro 
            500                 505                 510         


<210>  431
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH1B1__Homo_sapiens__NP_000683

<400>  431

Met Leu Arg Phe Leu Ala Pro Arg Leu Leu Ser Leu Gln Gly Arg Thr 
1               5                   10                  15      


Ala Arg Tyr Ser Ser Ala Ala Ala Leu Pro Ser Pro Ile Leu Asn Pro 
            20                  25                  30          


Asp Ile Pro Tyr Asn Gln Leu Phe Ile Asn Asn Glu Trp Gln Asp Ala 
        35                  40                  45              


Val Ser Lys Lys Thr Phe Pro Thr Val Asn Pro Thr Thr Gly Glu Val 
    50                  55                  60                  


Ile Gly His Val Ala Glu Gly Asp Arg Ala Asp Val Asp Arg Ala Val 
65                  70                  75                  80  


Lys Ala Ala Arg Glu Ala Phe Arg Leu Gly Ser Pro Trp Arg Arg Met 
                85                  90                  95      


Asp Ala Ser Glu Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Val 
            100                 105                 110         


Glu Arg Asp Arg Val Tyr Leu Ala Ser Leu Glu Thr Leu Asp Asn Gly 
        115                 120                 125             


Lys Pro Phe Gln Glu Ser Tyr Ala Leu Asp Leu Asp Glu Val Ile Lys 
    130                 135                 140                 


Val Tyr Arg Tyr Phe Ala Gly Trp Ala Asp Lys Trp His Gly Lys Thr 
145                 150                 155                 160 


Ile Pro Met Asp Gly Gln His Phe Cys Phe Thr Arg His Glu Pro Val 
                165                 170                 175     


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Gln 
            180                 185                 190         


Gly Trp Lys Leu Ala Pro Ala Leu Ala Thr Gly Asn Thr Val Val Met 
        195                 200                 205             


Lys Val Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Ser Leu 
    210                 215                 220                 


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Ile Thr Gly 
225                 230                 235                 240 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Gln His Val Asp Val Asp 
                245                 250                 255     


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly His Leu Ile Gln Lys 
            260                 265                 270         


Ala Ala Gly Asp Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
        275                 280                 285             


Lys Ser Pro Ser Ile Val Leu Ala Asp Ala Asp Met Glu His Ala Val 
    290                 295                 300                 


Glu Gln Cys His Glu Ala Leu Phe Phe Asn Met Gly Gln Cys Cys Cys 
305                 310                 315                 320 


Ala Gly Ser Arg Thr Phe Val Glu Glu Ser Ile Tyr Asn Glu Phe Leu 
                325                 330                 335     


Glu Arg Thr Val Glu Lys Ala Lys Gln Arg Lys Val Gly Asn Pro Phe 
            340                 345                 350         


Glu Leu Asp Thr Gln Gln Gly Pro Gln Val Asp Lys Glu Gln Phe Glu 
        355                 360                 365             


Arg Val Leu Gly Tyr Ile Gln Leu Gly Gln Lys Glu Gly Ala Lys Leu 
    370                 375                 380                 


Leu Cys Gly Gly Glu Arg Phe Gly Glu Arg Gly Phe Phe Ile Lys Pro 
385                 390                 395                 400 


Thr Val Phe Gly Gly Val Gln Asp Asp Met Arg Ile Ala Lys Glu Glu 
                405                 410                 415     


Ile Phe Gly Pro Val Gln Pro Leu Phe Lys Phe Lys Lys Ile Glu Glu 
            420                 425                 430         


Val Val Glu Arg Ala Asn Asn Thr Arg Tyr Gly Leu Ala Ala Ala Val 
        435                 440                 445             


Phe Thr Arg Asp Leu Asp Lys Ala Met Tyr Phe Thr Gln Ala Leu Gln 
    450                 455                 460                 


Ala Gly Thr Val Trp Val Asn Thr Tyr Asn Ile Val Thr Cys His Thr 
465                 470                 475                 480 


Pro Phe Gly Gly Phe Lys Glu Ser Gly Asn Gly Arg Glu Leu Gly Glu 
                485                 490                 495     


Asp Gly Leu Lys Ala Tyr Thr Glu Val Lys Thr Val Thr Ile Lys Val 
            500                 505                 510         


Pro Gln Lys Asn Ser 
        515         


<210>  432
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH1L1__Homo_sapiens__NP_001257293

<400>  432

Met Ala Gly Pro Ser Asn Pro Pro Ala Thr Met Lys Ile Ala Val Ile 
1               5                   10                  15      


Gly Gln Ser Leu Phe Gly Gln Glu Val Tyr Cys His Leu Arg Lys Glu 
            20                  25                  30          


Gly His Glu Val Val Gly Val Phe Thr Val Pro Asp Lys Asp Gly Lys 
        35                  40                  45              


Ala Asp Pro Leu Gly Leu Glu Ala Glu Lys Asp Gly Val Pro Val Phe 
    50                  55                  60                  


Lys Tyr Ser Arg Trp Arg Ala Lys Gly Gln Ala Leu Pro Asp Val Val 
65                  70                  75                  80  


Ala Lys Tyr Gln Ala Leu Gly Ala Glu Leu Asn Val Leu Pro Phe Cys 
                85                  90                  95      


Ser Gln Phe Ile Pro Met Glu Ile Ile Ser Ala Pro Arg His Gly Ser 
            100                 105                 110         


Ile Ile Tyr His Pro Ser Leu Leu Pro Arg His Arg Gly Ala Ser Ala 
        115                 120                 125             


Ile Asn Trp Thr Leu Ile His Gly Asp Lys Lys Gly Gly Phe Ser Ile 
    130                 135                 140                 


Phe Trp Ala Asp Asp Gly Leu Asp Thr Gly Asp Leu Leu Leu Gln Lys 
145                 150                 155                 160 


Glu Cys Glu Val Leu Pro Asp Asp Thr Val Ser Thr Leu Tyr Asn Arg 
                165                 170                 175     


Phe Leu Phe Pro Glu Gly Ile Lys Gly Met Val Gln Ala Val Arg Leu 
            180                 185                 190         


Ile Ala Glu Gly Lys Ala Pro Arg Leu Pro Gln Pro Glu Glu Gly Ala 
        195                 200                 205             


Thr Tyr Glu Gly Ile Gln Lys Lys Glu Thr Ala Lys Ile Asn Trp Asp 
    210                 215                 220                 


Gln Pro Ala Glu Ala Ile His Asn Trp Ile Arg Gly Asn Asp Lys Val 
225                 230                 235                 240 


Pro Gly Ala Trp Thr Glu Ala Cys Glu Gln Lys Leu Thr Phe Phe Asn 
                245                 250                 255     


Ser Thr Leu Asn Thr Ser Gly Leu Val Pro Glu Gly Asp Ala Leu Pro 
            260                 265                 270         


Ile Pro Gly Ala His Arg Pro Gly Val Val Thr Lys Ala Gly Leu Ile 
        275                 280                 285             


Leu Phe Gly Asn Asp Asp Lys Met Leu Leu Val Lys Asn Ile Gln Leu 
    290                 295                 300                 


Glu Asp Gly Lys Met Ile Leu Ala Ser Asn Phe Phe Lys Gly Ala Ala 
305                 310                 315                 320 


Ser Ser Val Leu Glu Leu Thr Glu Ala Glu Leu Val Thr Ala Glu Ala 
                325                 330                 335     


Val Arg Ser Val Trp Gln Arg Ile Leu Pro Lys Val Leu Glu Val Glu 
            340                 345                 350         


Asp Ser Thr Asp Phe Phe Lys Ser Gly Ala Ala Ser Val Asp Val Val 
        355                 360                 365             


Arg Leu Val Glu Glu Val Lys Glu Leu Cys Asp Gly Leu Glu Leu Glu 
    370                 375                 380                 


Asn Glu Asp Val Tyr Met Ala Ser Thr Phe Gly Asp Phe Ile Gln Leu 
385                 390                 395                 400 


Leu Val Arg Lys Leu Arg Gly Asp Asp Glu Glu Gly Glu Cys Ser Ile 
                405                 410                 415     


Asp Tyr Val Glu Met Ala Val Asn Lys Arg Thr Val Arg Met Pro His 
            420                 425                 430         


Gln Leu Phe Ile Gly Gly Glu Phe Val Asp Ala Glu Gly Ala Lys Thr 
        435                 440                 445             


Ser Glu Thr Ile Asn Pro Thr Asp Gly Ser Val Ile Cys Gln Val Ser 
    450                 455                 460                 


Leu Ala Gln Val Thr Asp Val Asp Lys Ala Val Ala Ala Ala Lys Asp 
465                 470                 475                 480 


Ala Phe Glu Asn Gly Arg Trp Gly Lys Ile Ser Ala Arg Asp Arg Gly 
                485                 490                 495     


Arg Leu Met Tyr Arg Leu Ala Asp Leu Met Glu Gln His Gln Glu Glu 
            500                 505                 510         


Leu Ala Thr Ile Glu Ala Leu Asp Ala Gly Ala Val Tyr Thr Leu Ala 
        515                 520                 525             


Leu Lys Thr His Val Gly Met Ser Ile Gln Thr Phe Arg Tyr Phe Ala 
    530                 535                 540                 


Gly Trp Cys Asp Lys Ile Gln Gly Ser Thr Ile Pro Ile Asn Gln Ala 
545                 550                 555                 560 


Arg Pro Asn Arg Asn Leu Thr Leu Thr Arg Lys Glu Pro Val Gly Val 
                565                 570                 575     


Cys Gly Ile Ile Ile Pro Trp Asn Tyr Pro Leu Met Met Leu Ser Trp 
            580                 585                 590         


Lys Thr Ala Ala Cys Leu Ala Ala Gly Asn Thr Val Val Ile Lys Pro 
        595                 600                 605             


Ala Gln Val Thr Pro Leu Thr Ala Leu Lys Phe Ala Glu Leu Thr Leu 
    610                 615                 620                 


Lys Ala Gly Ile Pro Lys Gly Val Val Asn Val Leu Pro Gly Ser Gly 
625                 630                 635                 640 


Ser Leu Val Gly Gln Arg Leu Ser Asp His Pro Asp Val Arg Lys Ile 
                645                 650                 655     


Gly Phe Thr Gly Ser Thr Glu Val Gly Lys His Ile Met Lys Ser Cys 
            660                 665                 670         


Ala Ile Ser Asn Val Lys Lys Val Ser Leu Glu Leu Gly Gly Lys Ser 
        675                 680                 685             


Pro Leu Ile Ile Phe Ala Asp Cys Asp Leu Asn Lys Ala Val Gln Met 
    690                 695                 700                 


Gly Met Ser Ser Val Phe Phe Asn Lys Gly Glu Asn Cys Ile Ala Ala 
705                 710                 715                 720 


Gly Arg Leu Phe Val Glu Asp Ser Ile His Asp Glu Phe Val Arg Arg 
                725                 730                 735     


Val Val Glu Glu Val Arg Lys Met Lys Val Gly Asn Pro Leu Asp Arg 
            740                 745                 750         


Asp Thr Asp His Gly Pro Gln Asn His His Ala His Leu Val Lys Leu 
        755                 760                 765             


Met Glu Tyr Cys Gln His Gly Val Lys Glu Gly Ala Thr Leu Val Cys 
    770                 775                 780                 


Gly Gly Asn Gln Val Pro Arg Pro Gly Phe Phe Phe Glu Pro Thr Val 
785                 790                 795                 800 


Phe Thr Asp Val Glu Asp His Met Phe Ile Ala Lys Glu Glu Ser Phe 
                805                 810                 815     


Gly Pro Val Met Ile Ile Ser Arg Phe Ala Asp Gly Asp Leu Asp Ala 
            820                 825                 830         


Val Leu Ser Arg Ala Asn Ala Thr Glu Phe Gly Leu Ala Ser Gly Val 
        835                 840                 845             


Phe Thr Arg Asp Ile Asn Lys Ala Leu Tyr Val Ser Asp Lys Leu Gln 
    850                 855                 860                 


Ala Gly Thr Val Phe Val Asn Thr Tyr Asn Lys Thr Asp Val Ala Ala 
865                 870                 875                 880 


Pro Phe Gly Gly Phe Lys Gln Ser Gly Phe Gly Lys Asp Leu Gly Glu 
                885                 890                 895     


Ala Ala Leu Asn Glu Tyr Leu Arg Val Lys Thr Val Thr Phe Glu Tyr 
            900                 905                 910         


<210>  433
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH2__Homo_sapiens__NP_000681

<400>  433

Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu 
1               5                   10                  15      


Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro 
            20                  25                  30          


Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala 
        35                  40                  45              


Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val 
    50                  55                  60                  


Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
65                  70                  75                  80  


Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met 
                85                  90                  95      


Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile 
            100                 105                 110         


Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly 
        115                 120                 125             


Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys 
    130                 135                 140                 


Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr 
145                 150                 155                 160 


Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val 
                165                 170                 175     


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln 
            180                 185                 190         


Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met 
        195                 200                 205             


Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu 
    210                 215                 220                 


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
225                 230                 235                 240 


Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp 
                245                 250                 255     


Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val 
            260                 265                 270         


Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
        275                 280                 285             


Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val 
    290                 295                 300                 


Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys 
305                 310                 315                 320 


Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val 
                325                 330                 335     


Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe 
            340                 345                 350         


Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys 
        355                 360                 365             


Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Glu Gly Ala Lys Leu 
    370                 375                 380                 


Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro 
385                 390                 395                 400 


Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu 
                405                 410                 415     


Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu 
            420                 425                 430         


Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val 
        435                 440                 445             


Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln 
    450                 455                 460                 


Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser 
465                 470                 475                 480 


Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu 
                485                 490                 495     


Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val 
            500                 505                 510         


Pro Gln Lys Asn Ser 
        515         


<210>  434
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH3A1__Homo_sapiens__NP_000682

<400>  434

Met Ser Lys Ile Ser Glu Ala Val Lys Arg Ala Arg Ala Ala Phe Ser 
1               5                   10                  15      


Ser Gly Arg Thr Arg Pro Leu Gln Phe Arg Ile Gln Gln Leu Glu Ala 
            20                  25                  30          


Leu Gln Arg Leu Ile Gln Glu Gln Glu Gln Glu Leu Val Gly Ala Leu 
        35                  40                  45              


Ala Ala Asp Leu His Lys Asn Glu Trp Asn Ala Tyr Tyr Glu Glu Val 
    50                  55                  60                  


Val Tyr Val Leu Glu Glu Ile Glu Tyr Met Ile Gln Lys Leu Pro Glu 
65                  70                  75                  80  


Trp Ala Ala Asp Glu Pro Val Glu Lys Thr Pro Gln Thr Gln Gln Asp 
                85                  90                  95      


Glu Leu Tyr Ile His Ser Glu Pro Leu Gly Val Val Leu Val Ile Gly 
            100                 105                 110         


Thr Trp Asn Tyr Pro Phe Asn Leu Thr Ile Gln Pro Met Val Gly Ala 
        115                 120                 125             


Ile Ala Ala Gly Asn Ser Val Val Leu Lys Pro Ser Glu Leu Ser Glu 
    130                 135                 140                 


Asn Met Ala Ser Leu Leu Ala Thr Ile Ile Pro Gln Tyr Leu Asp Lys 
145                 150                 155                 160 


Asp Leu Tyr Pro Val Ile Asn Gly Gly Val Pro Glu Thr Thr Glu Leu 
                165                 170                 175     


Leu Lys Glu Arg Phe Asp His Ile Leu Tyr Thr Gly Ser Thr Gly Val 
            180                 185                 190         


Gly Lys Ile Ile Met Thr Ala Ala Ala Lys His Leu Thr Pro Val Thr 
        195                 200                 205             


Leu Glu Leu Gly Gly Lys Ser Pro Cys Tyr Val Asp Lys Asn Cys Asp 
    210                 215                 220                 


Leu Asp Val Ala Cys Arg Arg Ile Ala Trp Gly Lys Phe Met Asn Ser 
225                 230                 235                 240 


Gly Gln Thr Cys Val Ala Pro Asp Tyr Ile Leu Cys Asp Pro Ser Ile 
                245                 250                 255     


Gln Asn Gln Ile Val Glu Lys Leu Lys Lys Ser Leu Lys Glu Phe Tyr 
            260                 265                 270         


Gly Glu Asp Ala Lys Lys Ser Arg Asp Tyr Gly Arg Ile Ile Ser Ala 
        275                 280                 285             


Arg His Phe Gln Arg Val Met Gly Leu Ile Glu Gly Gln Lys Val Ala 
    290                 295                 300                 


Tyr Gly Gly Thr Gly Asp Ala Ala Thr Arg Tyr Ile Ala Pro Thr Ile 
305                 310                 315                 320 


Leu Thr Asp Val Asp Pro Gln Ser Pro Val Met Gln Glu Glu Ile Phe 
                325                 330                 335     


Gly Pro Val Leu Pro Ile Val Cys Val Arg Ser Leu Glu Glu Ala Ile 
            340                 345                 350         


Gln Phe Ile Asn Gln Arg Glu Lys Pro Leu Ala Leu Tyr Met Phe Ser 
        355                 360                 365             


Ser Asn Asp Lys Val Ile Lys Lys Met Ile Ala Glu Thr Ser Ser Gly 
    370                 375                 380                 


Gly Val Ala Ala Asn Asp Val Ile Val His Ile Thr Leu His Ser Leu 
385                 390                 395                 400 


Pro Phe Gly Gly Val Gly Asn Ser Gly Met Gly Ser Tyr His Gly Lys 
                405                 410                 415     


Lys Ser Phe Glu Thr Phe Ser His Arg Arg Ser Cys Leu Val Arg Pro 
            420                 425                 430         


Leu Met Asn Asp Glu Gly Leu Lys Val Arg Tyr Pro Pro Ser Pro Ala 
        435                 440                 445             


Lys Met Thr Gln His 
    450             


<210>  435
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH3A2__Homo_sapiens__NP_000373

<400>  435

Met Glu Leu Glu Val Arg Arg Val Arg Gln Ala Phe Leu Ser Gly Arg 
1               5                   10                  15      


Ser Arg Pro Leu Arg Phe Arg Leu Gln Gln Leu Glu Ala Leu Arg Arg 
            20                  25                  30          


Met Val Gln Glu Arg Glu Lys Asp Ile Leu Thr Ala Ile Ala Ala Asp 
        35                  40                  45              


Leu Cys Lys Ser Glu Phe Asn Val Tyr Ser Gln Glu Val Ile Thr Val 
    50                  55                  60                  


Leu Gly Glu Ile Asp Phe Met Leu Glu Asn Leu Pro Glu Trp Val Thr 
65                  70                  75                  80  


Ala Lys Pro Val Lys Lys Asn Val Leu Thr Met Leu Asp Glu Ala Tyr 
                85                  90                  95      


Ile Gln Pro Gln Pro Leu Gly Val Val Leu Ile Ile Gly Ala Trp Asn 
            100                 105                 110         


Tyr Pro Phe Val Leu Thr Ile Gln Pro Leu Ile Gly Ala Ile Ala Ala 
        115                 120                 125             


Gly Asn Ala Val Ile Ile Lys Pro Ser Glu Leu Ser Glu Asn Thr Ala 
    130                 135                 140                 


Lys Ile Leu Ala Lys Leu Leu Pro Gln Tyr Leu Asp Gln Asp Leu Tyr 
145                 150                 155                 160 


Ile Val Ile Asn Gly Gly Val Glu Glu Thr Thr Glu Leu Leu Lys Gln 
                165                 170                 175     


Arg Phe Asp His Ile Phe Tyr Thr Gly Asn Thr Ala Val Gly Lys Ile 
            180                 185                 190         


Val Met Glu Ala Ala Ala Lys His Leu Thr Pro Val Thr Leu Glu Leu 
        195                 200                 205             


Gly Gly Lys Ser Pro Cys Tyr Ile Asp Lys Asp Cys Asp Leu Asp Ile 
    210                 215                 220                 


Val Cys Arg Arg Ile Thr Trp Gly Lys Tyr Met Asn Cys Gly Gln Thr 
225                 230                 235                 240 


Cys Ile Ala Pro Asp Tyr Ile Leu Cys Glu Ala Ser Leu Gln Asn Gln 
                245                 250                 255     


Ile Val Trp Lys Ile Lys Glu Thr Val Lys Glu Phe Tyr Gly Glu Asn 
            260                 265                 270         


Ile Lys Glu Ser Pro Asp Tyr Glu Arg Ile Ile Asn Leu Arg His Phe 
        275                 280                 285             


Lys Arg Ile Leu Ser Leu Leu Glu Gly Gln Lys Ile Ala Phe Gly Gly 
    290                 295                 300                 


Glu Thr Asp Glu Ala Thr Arg Tyr Ile Ala Pro Thr Val Leu Thr Asp 
305                 310                 315                 320 


Val Asp Pro Lys Thr Lys Val Met Gln Glu Glu Ile Phe Gly Pro Ile 
                325                 330                 335     


Leu Pro Ile Val Pro Val Lys Asn Val Asp Glu Ala Ile Asn Phe Ile 
            340                 345                 350         


Asn Glu Arg Glu Lys Pro Leu Ala Leu Tyr Val Phe Ser His Asn His 
        355                 360                 365             


Lys Leu Ile Lys Arg Met Ile Asp Glu Thr Ser Ser Gly Gly Val Thr 
    370                 375                 380                 


Gly Asn Asp Val Ile Met His Phe Thr Leu Asn Ser Phe Pro Phe Gly 
385                 390                 395                 400 


Gly Val Gly Ser Ser Gly Met Gly Ala Tyr His Gly Lys His Ser Phe 
                405                 410                 415     


Asp Thr Phe Ser His Gln Arg Pro Cys Leu Leu Lys Ser Leu Lys Arg 
            420                 425                 430         


Glu Gly Ala Asn Lys Leu Arg Tyr Pro Pro Asn Ser Gln Ser Lys Val 
        435                 440                 445             


Asp Trp Gly Lys Phe Phe Leu Leu Lys Arg Phe Asn Lys Glu Lys Leu 
    450                 455                 460                 


Gly Leu Leu Leu Leu Thr Phe Leu Gly Ile Val Ala Ala Val Leu Val 
465                 470                 475                 480 


Lys Ala Glu Tyr Tyr 
                485 


<210>  436
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH3B1__Homo_sapiens__NP_000685

<400>  436

Met Asp Pro Leu Gly Asp Thr Leu Arg Arg Leu Arg Glu Ala Phe His 
1               5                   10                  15      


Ala Gly Arg Thr Arg Pro Ala Glu Phe Arg Ala Ala Gln Leu Gln Gly 
            20                  25                  30          


Leu Gly Arg Phe Leu Gln Glu Asn Lys Gln Leu Leu His Asp Ala Leu 
        35                  40                  45              


Ala Gln Asp Leu His Lys Ser Ala Phe Glu Ser Glu Val Ser Glu Val 
    50                  55                  60                  


Ala Ile Ser Gln Gly Glu Val Thr Leu Ala Leu Arg Asn Leu Arg Ala 
65                  70                  75                  80  


Trp Met Lys Asp Glu Arg Val Pro Lys Asn Leu Ala Thr Gln Leu Asp 
                85                  90                  95      


Ser Ala Phe Ile Arg Lys Glu Pro Phe Gly Leu Val Leu Ile Ile Ala 
            100                 105                 110         


Pro Trp Asn Tyr Pro Leu Asn Leu Thr Leu Val Pro Leu Val Gly Ala 
        115                 120                 125             


Leu Ala Ala Gly Asn Cys Val Val Leu Lys Pro Ser Glu Ile Ser Lys 
    130                 135                 140                 


Asn Val Glu Lys Ile Leu Ala Glu Val Leu Pro Gln Tyr Val Asp Gln 
145                 150                 155                 160 


Ser Cys Phe Ala Val Val Leu Gly Gly Pro Gln Glu Thr Gly Gln Leu 
                165                 170                 175     


Leu Glu His Arg Phe Asp Tyr Ile Phe Phe Thr Gly Ser Pro Arg Val 
            180                 185                 190         


Gly Lys Ile Val Met Thr Ala Ala Ala Lys His Leu Thr Pro Val Thr 
        195                 200                 205             


Leu Glu Leu Gly Gly Lys Asn Pro Cys Tyr Val Asp Asp Asn Cys Asp 
    210                 215                 220                 


Pro Gln Thr Val Ala Asn Arg Val Ala Trp Phe Arg Tyr Phe Asn Ala 
225                 230                 235                 240 


Gly Gln Thr Cys Val Ala Pro Asp Tyr Val Leu Cys Ser Pro Glu Met 
                245                 250                 255     


Gln Glu Arg Leu Leu Pro Ala Leu Gln Ser Thr Ile Thr Arg Phe Tyr 
            260                 265                 270         


Gly Asp Asp Pro Gln Ser Ser Pro Asn Leu Gly Arg Ile Ile Asn Gln 
        275                 280                 285             


Lys Gln Phe Gln Arg Leu Arg Ala Leu Leu Gly Cys Gly Arg Val Ala 
    290                 295                 300                 


Ile Gly Gly Gln Ser Asp Glu Ser Asp Arg Tyr Ile Ala Pro Thr Val 
305                 310                 315                 320 


Leu Val Asp Val Gln Glu Met Glu Pro Val Met Gln Glu Glu Ile Phe 
                325                 330                 335     


Gly Pro Ile Leu Pro Ile Val Asn Val Gln Ser Leu Asp Glu Ala Ile 
            340                 345                 350         


Glu Phe Ile Asn Arg Arg Glu Lys Pro Leu Ala Leu Tyr Ala Phe Ser 
        355                 360                 365             


Asn Ser Ser Gln Val Val Lys Arg Val Leu Thr Gln Thr Ser Ser Gly 
    370                 375                 380                 


Gly Phe Cys Gly Asn Asp Gly Phe Met His Met Thr Leu Ala Ser Leu 
385                 390                 395                 400 


Pro Phe Gly Gly Val Gly Ala Ser Gly Met Gly Arg Tyr His Gly Lys 
                405                 410                 415     


Phe Ser Phe Asp Thr Phe Ser His His Arg Ala Cys Leu Leu Arg Ser 
            420                 425                 430         


Pro Gly Met Glu Lys Leu Asn Ala Leu Arg Tyr Pro Pro Gln Ser Pro 
        435                 440                 445             


Arg Arg Leu Arg Met Leu Leu Val Ala Met Glu Ala Gln Gly Cys Ser 
    450                 455                 460                 


Cys Thr Leu Leu 
465             


<210>  437
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH4A1__Homo_sapiens__NP_001306147

<400>  437

Met Leu Leu Pro Ala Pro Ala Leu Arg Arg Ala Leu Leu Ser Arg Pro 
1               5                   10                  15      


Trp Thr Gly Ala Gly Leu Arg Trp Lys His Thr Ser Ser Leu Lys Val 
            20                  25                  30          


Ala Asn Glu Pro Val Leu Ala Phe Thr Gln Gly Ser Pro Glu Arg Asp 
        35                  40                  45              


Ala Leu Gln Lys Ala Leu Lys Asp Leu Lys Gly Arg Met Glu Ala Ile 
    50                  55                  60                  


Pro Cys Val Val Gly Asp Glu Glu Val Trp Thr Ser Asp Val Gln Tyr 
65                  70                  75                  80  


Gln Val Ser Pro Phe Asn His Gly His Lys Val Ala Lys Phe Cys Tyr 
                85                  90                  95      


Ala Asp Lys Ser Leu Leu Asn Lys Ala Ile Glu Ala Ala Leu Ala Ala 
            100                 105                 110         


Arg Lys Glu Trp Asp Leu Lys Pro Ile Ala Asp Arg Ala Gln Ile Phe 
        115                 120                 125             


Leu Lys Ala Ala Asp Met Leu Ser Gly Pro Arg Arg Ala Glu Ile Leu 
    130                 135                 140                 


Ala Lys Thr Met Val Gly Gln Gly Lys Thr Val Ile Gln Ala Glu Ile 
145                 150                 155                 160 


Asp Ala Ala Ala Glu Leu Ile Asp Phe Phe Arg Phe Asn Ala Lys Tyr 
                165                 170                 175     


Ala Val Glu Leu Glu Gly Gln Gln Pro Ile Ser Val Pro Pro Ser Thr 
            180                 185                 190         


Asn Ser Thr Val Tyr Arg Gly Leu Glu Gly Phe Val Ala Ala Ile Ser 
        195                 200                 205             


Pro Phe Asn Phe Thr Ala Ile Gly Gly Asn Leu Ala Gly Ala Pro Ala 
    210                 215                 220                 


Leu Met Gly Asn Val Val Leu Trp Lys Pro Ser Asp Thr Ala Met Leu 
225                 230                 235                 240 


Ala Ser Tyr Ala Val Tyr Arg Ile Leu Arg Glu Ala Gly Leu Pro Pro 
                245                 250                 255     


Asn Ile Ile Gln Phe Val Pro Ala Asp Gly Pro Leu Phe Gly Asp Thr 
            260                 265                 270         


Val Thr Ser Ser Glu His Leu Cys Gly Ile Asn Phe Thr Gly Ser Val 
        275                 280                 285             


Pro Thr Phe Lys His Leu Trp Lys Gln Val Ala Gln Asn Leu Asp Arg 
    290                 295                 300                 


Phe His Thr Phe Pro Arg Leu Ala Gly Glu Cys Gly Gly Lys Asn Phe 
305                 310                 315                 320 


His Phe Val His Arg Ser Ala Asp Val Glu Ser Val Val Ser Gly Thr 
                325                 330                 335     


Leu Arg Ser Ala Phe Glu Tyr Gly Gly Gln Lys Cys Ser Ala Cys Ser 
            340                 345                 350         


Arg Leu Tyr Val Pro His Ser Leu Trp Pro Gln Ile Lys Gly Arg Leu 
        355                 360                 365             


Leu Glu Glu His Ser Arg Ile Lys Val Gly Asp Pro Ala Glu Asp Phe 
    370                 375                 380                 


Gly Thr Phe Phe Ser Ala Val Ile Asp Ala Lys Glu Ile Phe Gly Pro 
385                 390                 395                 400 


Val Leu Ser Val Tyr Val Tyr Pro Asp Asp Lys Tyr Lys Glu Thr Leu 
                405                 410                 415     


Gln Leu Val Asp Ser Thr Thr Ser Tyr Gly Leu Thr Gly Ala Val Phe 
            420                 425                 430         


Ser Gln Asp Lys Asp Val Val Gln Glu Ala Thr Lys Val Leu Arg Asn 
        435                 440                 445             


Ala Ala Gly Asn Phe Tyr Ile Asn Asp Lys Ser Thr Gly Ser Ile Val 
    450                 455                 460                 


Gly Gln Gln Pro Phe Gly Gly Ala Arg Ala Ser Gly Thr Asn Asp Lys 
465                 470                 475                 480 


Pro Gly Gly Pro His Tyr Ile Leu Arg Trp Thr Ser Pro Gln Val Ile 
                485                 490                 495     


Lys Glu Thr His Lys Pro Leu Gly Asp Trp Ser Tyr Ala Tyr Met Gln 
            500                 505                 510         


<210>  438
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH5A1__Homo_sapiens__NP_733936

<400>  438

Met Ala Thr Cys Ile Trp Leu Arg Ser Cys Gly Ala Arg Arg Leu Gly 
1               5                   10                  15      


Ser Thr Phe Pro Gly Cys Arg Leu Arg Pro Arg Ala Gly Gly Leu Val 
            20                  25                  30          


Pro Ala Ser Gly Pro Ala Pro Gly Pro Ala Gln Leu Arg Cys Tyr Ala 
        35                  40                  45              


Gly Arg Leu Ala Gly Leu Ser Ala Ala Leu Leu Arg Thr Asp Ser Phe 
    50                  55                  60                  


Val Gly Gly Arg Trp Leu Pro Ala Ala Ala Thr Phe Pro Val Gln Asp 
65                  70                  75                  80  


Pro Ala Ser Gly Ala Ala Leu Gly Met Val Ala Asp Cys Gly Val Arg 
                85                  90                  95      


Glu Ala Arg Ala Ala Val Arg Ala Ala Tyr Glu Ala Phe Cys Arg Trp 
            100                 105                 110         


Arg Glu Val Ser Ala Lys Glu Arg Ser Ser Leu Leu Arg Lys Trp Tyr 
        115                 120                 125             


Asn Leu Met Ile Gln Asn Lys Asp Asp Leu Ala Arg Ile Ile Thr Ala 
    130                 135                 140                 


Glu Ser Gly Lys Pro Leu Lys Glu Ala His Gly Glu Ile Leu Tyr Ser 
145                 150                 155                 160 


Ala Phe Phe Leu Glu Trp Phe Ser Glu Glu Ala Arg Arg Val Tyr Gly 
                165                 170                 175     


Asp Ile Ile His Thr Pro Ala Lys Asp Arg Arg Ala Leu Val Leu Lys 
            180                 185                 190         


Gln Pro Ile Gly Val Ala Ala Val Ile Thr Pro Trp Asn Phe Pro Ser 
        195                 200                 205             


Ala Met Ile Thr Arg Lys Val Gly Ala Ala Leu Ala Ala Gly Cys Thr 
    210                 215                 220                 


Val Val Val Lys Pro Ala Glu Asp Thr Pro Phe Ser Ala Leu Ala Leu 
225                 230                 235                 240 


Ala Glu Val Asn Gln Gly Phe Leu Leu Asp Leu Asp Pro Leu Leu Leu 
                245                 250                 255     


Ala Ser Gln Ala Gly Ile Pro Ser Gly Val Tyr Asn Val Ile Pro Cys 
            260                 265                 270         


Ser Arg Lys Asn Ala Lys Glu Val Gly Glu Ala Ile Cys Thr Asp Pro 
        275                 280                 285             


Leu Val Ser Lys Ile Ser Phe Thr Gly Ser Thr Thr Thr Gly Lys Ile 
    290                 295                 300                 


Leu Leu His His Ala Ala Asn Ser Val Lys Arg Val Ser Met Glu Leu 
305                 310                 315                 320 


Gly Gly Leu Ala Pro Phe Ile Val Phe Asp Ser Ala Asn Val Asp Gln 
                325                 330                 335     


Ala Val Ala Gly Ala Met Ala Ser Lys Phe Arg Asn Thr Gly Gln Thr 
            340                 345                 350         


Cys Val Cys Ser Asn Gln Phe Leu Val Gln Arg Gly Ile His Asp Ala 
        355                 360                 365             


Phe Val Lys Ala Phe Ala Glu Ala Met Lys Lys Asn Leu Arg Val Gly 
    370                 375                 380                 


Asn Gly Phe Glu Glu Gly Thr Thr Gln Gly Pro Leu Ile Asn Glu Lys 
385                 390                 395                 400 


Ala Val Glu Lys Val Glu Lys Gln Val Asn Asp Ala Val Ser Lys Gly 
                405                 410                 415     


Ala Thr Val Val Thr Gly Gly Lys Arg His Gln Leu Gly Lys Asn Phe 
            420                 425                 430         


Phe Glu Pro Thr Leu Leu Cys Asn Val Thr Gln Asp Met Leu Cys Thr 
        435                 440                 445             


His Glu Glu Thr Phe Gly Pro Leu Ala Pro Val Ile Lys Phe Asp Thr 
    450                 455                 460                 


Glu Glu Glu Ala Ile Ala Ile Ala Asn Ala Ala Asp Val Gly Leu Ala 
465                 470                 475                 480 


Gly Tyr Phe Tyr Ser Gln Asp Pro Ala Gln Ile Trp Arg Val Ala Glu 
                485                 490                 495     


Gln Leu Glu Val Gly Met Val Gly Val Asn Glu Gly Leu Ile Ser Ser 
            500                 505                 510         


Val Glu Cys Pro Phe Gly Gly Val Lys Gln Ser Gly Leu Gly Arg Glu 
        515                 520                 525             


Gly Ser Lys Tyr Gly Ile Asp Glu Tyr Leu Glu Leu Lys Tyr Val Cys 
    530                 535                 540                 


Tyr Gly Gly Leu 
545             


<210>  439
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH6A1__Homo_sapiens__NP_005580

<400>  439

Met Ala Ala Leu Leu Ala Ala Ala Ala Val Arg Ala Arg Ile Leu Gln 
1               5                   10                  15      


Val Ser Ser Lys Val Lys Ser Ser Pro Thr Trp Tyr Ser Ala Ser Ser 
            20                  25                  30          


Phe Ser Ser Ser Val Pro Thr Val Lys Leu Phe Ile Gly Gly Lys Phe 
        35                  40                  45              


Val Glu Ser Lys Ser Asp Lys Trp Ile Asp Ile His Asn Pro Ala Thr 
    50                  55                  60                  


Asn Glu Val Ile Gly Arg Val Pro Gln Ala Thr Lys Ala Glu Met Asp 
65                  70                  75                  80  


Ala Ala Ile Ala Ser Cys Lys Arg Ala Phe Pro Ala Trp Ala Asp Thr 
                85                  90                  95      


Ser Val Leu Ser Arg Gln Gln Val Leu Leu Arg Tyr Gln Gln Leu Ile 
            100                 105                 110         


Lys Glu Asn Leu Lys Glu Ile Ala Lys Leu Ile Thr Leu Glu Gln Gly 
        115                 120                 125             


Lys Thr Leu Ala Asp Ala Glu Gly Asp Val Phe Arg Gly Leu Gln Val 
    130                 135                 140                 


Val Glu His Ala Cys Ser Val Thr Ser Leu Met Met Gly Glu Thr Met 
145                 150                 155                 160 


Pro Ser Ile Thr Lys Asp Met Asp Leu Tyr Ser Tyr Arg Leu Pro Leu 
                165                 170                 175     


Gly Val Cys Ala Gly Ile Ala Pro Phe Asn Phe Pro Ala Met Ile Pro 
            180                 185                 190         


Leu Trp Met Phe Pro Met Ala Met Val Cys Gly Asn Thr Phe Leu Met 
        195                 200                 205             


Lys Pro Ser Glu Arg Val Pro Gly Ala Thr Met Leu Leu Ala Lys Leu 
    210                 215                 220                 


Leu Gln Asp Ser Gly Ala Pro Asp Gly Thr Leu Asn Ile Ile His Gly 
225                 230                 235                 240 


Gln His Glu Ala Val Asn Phe Ile Cys Asp His Pro Asp Ile Lys Ala 
                245                 250                 255     


Ile Ser Phe Val Gly Ser Asn Lys Ala Gly Glu Tyr Ile Phe Glu Arg 
            260                 265                 270         


Gly Ser Arg His Gly Lys Arg Val Gln Ala Asn Met Gly Ala Lys Asn 
        275                 280                 285             


His Gly Val Val Met Pro Asp Ala Asn Lys Glu Asn Thr Leu Asn Gln 
    290                 295                 300                 


Leu Val Gly Ala Ala Phe Gly Ala Ala Gly Gln Arg Cys Met Ala Leu 
305                 310                 315                 320 


Ser Thr Ala Val Leu Val Gly Glu Ala Lys Lys Trp Leu Pro Glu Leu 
                325                 330                 335     


Val Glu His Ala Lys Asn Leu Arg Val Asn Ala Gly Asp Gln Pro Gly 
            340                 345                 350         


Ala Asp Leu Gly Pro Leu Ile Thr Pro Gln Ala Lys Glu Arg Val Cys 
        355                 360                 365             


Asn Leu Ile Asp Ser Gly Thr Lys Glu Gly Ala Ser Ile Leu Leu Asp 
    370                 375                 380                 


Gly Arg Lys Ile Lys Val Lys Gly Tyr Glu Asn Gly Asn Phe Val Gly 
385                 390                 395                 400 


Pro Thr Ile Ile Ser Asn Val Lys Pro Asn Met Thr Cys Tyr Lys Glu 
                405                 410                 415     


Glu Ile Phe Gly Pro Val Leu Val Val Leu Glu Thr Glu Thr Leu Asp 
            420                 425                 430         


Glu Ala Ile Gln Ile Val Asn Asn Asn Pro Tyr Gly Asn Gly Thr Ala 
        435                 440                 445             


Ile Phe Thr Thr Asn Gly Ala Thr Ala Arg Lys Tyr Ala His Leu Val 
    450                 455                 460                 


Asp Val Gly Gln Val Gly Val Asn Val Pro Ile Pro Val Pro Leu Pro 
465                 470                 475                 480 


Met Phe Ser Phe Thr Gly Ser Arg Ser Ser Phe Arg Gly Asp Thr Asn 
                485                 490                 495     


Phe Tyr Gly Lys Gln Gly Ile Gln Phe Tyr Thr Gln Leu Lys Thr Ile 
            500                 505                 510         


Thr Ser Gln Trp Lys Glu Glu Asp Ala Thr Leu Ser Ser Pro Ala Val 
        515                 520                 525             


Val Met Pro Thr Met Gly Arg 
    530                 535 


<210>  440
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH7A1__Homo_sapiens__NP_001173

<400>  440

Met Trp Arg Leu Pro Arg Ala Leu Cys Val His Ala Ala Lys Thr Ser 
1               5                   10                  15      


Lys Leu Ser Gly Pro Trp Ser Arg Pro Ala Ala Phe Met Ser Thr Leu 
            20                  25                  30          


Leu Ile Asn Gln Pro Gln Tyr Ala Trp Leu Lys Glu Leu Gly Leu Arg 
        35                  40                  45              


Glu Glu Asn Glu Gly Val Tyr Asn Gly Ser Trp Gly Gly Arg Gly Glu 
    50                  55                  60                  


Val Ile Thr Thr Tyr Cys Pro Ala Asn Asn Glu Pro Ile Ala Arg Val 
65                  70                  75                  80  


Arg Gln Ala Ser Val Ala Asp Tyr Glu Glu Thr Val Lys Lys Ala Arg 
                85                  90                  95      


Glu Ala Trp Lys Ile Trp Ala Asp Ile Pro Ala Pro Lys Arg Gly Glu 
            100                 105                 110         


Ile Val Arg Gln Ile Gly Asp Ala Leu Arg Glu Lys Ile Gln Val Leu 
        115                 120                 125             


Gly Ser Leu Val Ser Leu Glu Met Gly Lys Ile Leu Val Glu Gly Val 
    130                 135                 140                 


Gly Glu Val Gln Glu Tyr Val Asp Ile Cys Asp Tyr Ala Val Gly Leu 
145                 150                 155                 160 


Ser Arg Met Ile Gly Gly Pro Ile Leu Pro Ser Glu Arg Ser Gly His 
                165                 170                 175     


Ala Leu Ile Glu Gln Trp Asn Pro Val Gly Leu Val Gly Ile Ile Thr 
            180                 185                 190         


Ala Phe Asn Phe Pro Val Ala Val Tyr Gly Trp Asn Asn Ala Ile Ala 
        195                 200                 205             


Met Ile Cys Gly Asn Val Cys Leu Trp Lys Gly Ala Pro Thr Thr Ser 
    210                 215                 220                 


Leu Ile Ser Val Ala Val Thr Lys Ile Ile Ala Lys Val Leu Glu Asp 
225                 230                 235                 240 


Asn Lys Leu Pro Gly Ala Ile Cys Ser Leu Thr Cys Gly Gly Ala Asp 
                245                 250                 255     


Ile Gly Thr Ala Met Ala Lys Asp Glu Arg Val Asn Leu Leu Ser Phe 
            260                 265                 270         


Thr Gly Ser Thr Gln Val Gly Lys Gln Val Gly Leu Met Val Gln Glu 
        275                 280                 285             


Arg Phe Gly Arg Ser Leu Leu Glu Leu Gly Gly Asn Asn Ala Ile Ile 
    290                 295                 300                 


Ala Phe Glu Asp Ala Asp Leu Ser Leu Val Val Pro Ser Ala Leu Phe 
305                 310                 315                 320 


Ala Ala Val Gly Thr Ala Gly Gln Arg Cys Thr Thr Ala Arg Arg Leu 
                325                 330                 335     


Phe Ile His Glu Ser Ile His Asp Glu Val Val Asn Arg Leu Lys Lys 
            340                 345                 350         


Ala Tyr Ala Gln Ile Arg Val Gly Asn Pro Trp Asp Pro Asn Val Leu 
        355                 360                 365             


Tyr Gly Pro Leu His Thr Lys Gln Ala Val Ser Met Phe Leu Gly Ala 
    370                 375                 380                 


Val Glu Glu Ala Lys Lys Glu Gly Gly Thr Val Val Tyr Gly Gly Lys 
385                 390                 395                 400 


Val Met Asp Arg Pro Gly Asn Tyr Val Glu Pro Thr Ile Val Thr Gly 
                405                 410                 415     


Leu Gly His Asp Ala Ser Ile Ala His Thr Glu Thr Phe Ala Pro Ile 
            420                 425                 430         


Leu Tyr Val Phe Lys Phe Lys Asn Glu Glu Glu Val Phe Ala Trp Asn 
        435                 440                 445             


Asn Glu Val Lys Gln Gly Leu Ser Ser Ser Ile Phe Thr Lys Asp Leu 
    450                 455                 460                 


Gly Arg Ile Phe Arg Trp Leu Gly Pro Lys Gly Ser Asp Cys Gly Ile 
465                 470                 475                 480 


Val Asn Val Asn Ile Pro Thr Ser Gly Ala Glu Ile Gly Gly Ala Phe 
                485                 490                 495     


Gly Gly Glu Lys His Thr Gly Gly Gly Arg Glu Ser Gly Ser Asp Ala 
            500                 505                 510         


Trp Lys Gln Tyr Met Arg Arg Ser Thr Cys Thr Ile Asn Tyr Ser Lys 
        515                 520                 525             


Asp Leu Pro Leu Ala Gln Gly Ile Lys Phe Gln 
    530                 535                 


<210>  441
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDH9A1__Homo_sapiens__NP_000687

<400>  441

Met Phe Leu Arg Ala Gly Leu Ala Ala Leu Ser Pro Leu Leu Arg Ser 
1               5                   10                  15      


Leu Arg Pro Ser Pro Val Ala Ala Met Ser Thr Gly Thr Phe Val Val 
            20                  25                  30          


Ser Gln Pro Leu Asn Tyr Arg Gly Gly Ala Arg Val Glu Pro Ala Asp 
        35                  40                  45              


Ala Ser Gly Thr Glu Lys Ala Phe Glu Pro Ala Thr Gly Arg Val Ile 
    50                  55                  60                  


Ala Thr Phe Thr Cys Ser Gly Glu Lys Glu Val Asn Leu Ala Val Gln 
65                  70                  75                  80  


Asn Ala Lys Ala Ala Phe Lys Ile Trp Ser Gln Lys Ser Gly Met Glu 
                85                  90                  95      


Arg Cys Arg Ile Leu Leu Glu Ala Ala Arg Ile Ile Arg Glu Arg Glu 
            100                 105                 110         


Asp Glu Ile Ala Thr Met Glu Cys Ile Asn Asn Gly Lys Ser Ile Phe 
        115                 120                 125             


Glu Ala Arg Leu Asp Ile Asp Ile Ser Trp Gln Cys Leu Glu Tyr Tyr 
    130                 135                 140                 


Ala Gly Leu Ala Ala Ser Met Ala Gly Glu His Ile Gln Leu Pro Gly 
145                 150                 155                 160 


Gly Ser Phe Gly Tyr Thr Arg Arg Glu Pro Leu Gly Val Cys Val Gly 
                165                 170                 175     


Ile Gly Ala Trp Asn Tyr Pro Phe Gln Ile Ala Ser Trp Lys Ser Ala 
            180                 185                 190         


Pro Ala Leu Ala Cys Gly Asn Ala Met Val Phe Lys Pro Ser Pro Phe 
        195                 200                 205             


Thr Pro Val Ser Ala Leu Leu Leu Ala Glu Ile Tyr Ser Glu Ala Gly 
    210                 215                 220                 


Val Pro Pro Gly Leu Phe Asn Val Val Gln Gly Gly Ala Ala Thr Gly 
225                 230                 235                 240 


Gln Phe Leu Cys Gln His Pro Asp Val Ala Lys Val Ser Phe Thr Gly 
                245                 250                 255     


Ser Val Pro Thr Gly Met Lys Ile Met Glu Met Ser Ala Lys Gly Ile 
            260                 265                 270         


Lys Pro Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Leu Ile Ile Phe 
        275                 280                 285             


Ser Asp Cys Asp Met Asn Asn Ala Val Lys Gly Ala Leu Met Ala Asn 
    290                 295                 300                 


Phe Leu Thr Gln Gly Gln Val Cys Cys Asn Gly Thr Arg Val Phe Val 
305                 310                 315                 320 


Gln Lys Glu Ile Leu Asp Lys Phe Thr Glu Glu Val Val Lys Gln Thr 
                325                 330                 335     


Gln Arg Ile Lys Ile Gly Asp Pro Leu Leu Glu Asp Thr Arg Met Gly 
            340                 345                 350         


Pro Leu Ile Asn Arg Pro His Leu Glu Arg Val Leu Gly Phe Val Lys 
        355                 360                 365             


Val Ala Lys Glu Gln Gly Ala Lys Val Leu Cys Gly Gly Asp Ile Tyr 
    370                 375                 380                 


Val Pro Glu Asp Pro Lys Leu Lys Asp Gly Tyr Tyr Met Arg Pro Cys 
385                 390                 395                 400 


Val Leu Thr Asn Cys Arg Asp Asp Met Thr Cys Val Lys Glu Glu Ile 
                405                 410                 415     


Phe Gly Pro Val Met Ser Ile Leu Ser Phe Asp Thr Glu Ala Glu Val 
            420                 425                 430         


Leu Glu Arg Ala Asn Asp Thr Thr Phe Gly Leu Ala Ala Gly Val Phe 
        435                 440                 445             


Thr Arg Asp Ile Gln Arg Ala His Arg Val Val Ala Glu Leu Gln Ala 
    450                 455                 460                 


Gly Thr Cys Phe Ile Asn Asn Tyr Asn Val Ser Pro Val Glu Leu Pro 
465                 470                 475                 480 


Phe Gly Gly Tyr Lys Lys Ser Gly Phe Gly Arg Glu Asn Gly Arg Val 
                485                 490                 495     


Thr Ile Glu Tyr Tyr Ser Gln Leu Lys Thr Val Cys Val Glu Met Gly 
            500                 505                 510         


Asp Val Glu Ser Ala Phe 
        515             


<210>  442
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDOA__Homo_sapiens__NP_001230106

<400>  442

Met Ala Arg Arg Lys Pro Glu Gly Ser Ser Phe Asn Met Thr His Leu 
1               5                   10                  15      


Ser Met Ala Met Ala Phe Ser Phe Pro Pro Val Ala Ser Gly Gln Leu 
            20                  25                  30          


His Pro Gln Leu Gly Asn Thr Gln His Gln Thr Glu Leu Gly Lys Glu 
        35                  40                  45              


Leu Ala Thr Thr Ser Thr Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro 
    50                  55                  60                  


Glu Gln Lys Lys Glu Leu Ser Asp Ile Ala His Arg Ile Val Ala Pro 
65                  70                  75                  80  


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys 
                85                  90                  95      


Arg Leu Gln Ser Ile Gly Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe 
            100                 105                 110         


Tyr Arg Gln Leu Leu Leu Thr Ala Asp Asp Arg Val Asn Pro Cys Ile 
        115                 120                 125             


Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp Asp 
    130                 135                 140                 


Gly Arg Pro Phe Pro Gln Val Ile Lys Ser Lys Gly Gly Val Val Gly 
145                 150                 155                 160 


Ile Lys Val Asp Lys Gly Val Val Pro Leu Ala Gly Thr Asn Gly Glu 
                165                 170                 175     


Thr Thr Thr Gln Gly Leu Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr 
            180                 185                 190         


Lys Lys Asp Gly Ala Asp Phe Ala Lys Trp Arg Cys Val Leu Lys Ile 
        195                 200                 205             


Gly Glu His Thr Pro Ser Ala Leu Ala Ile Met Glu Asn Ala Asn Val 
    210                 215                 220                 


Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn Gly Ile Val Pro Ile 
225                 230                 235                 240 


Val Glu Pro Glu Ile Leu Pro Asp Gly Asp His Asp Leu Lys Arg Cys 
                245                 250                 255     


Gln Tyr Val Thr Glu Lys Val Leu Ala Ala Val Tyr Lys Ala Leu Ser 
            260                 265                 270         


Asp His His Ile Tyr Leu Glu Gly Thr Leu Leu Lys Pro Asn Met Val 
        275                 280                 285             


Thr Pro Gly His Ala Cys Thr Gln Lys Phe Ser His Glu Glu Ile Ala 
    290                 295                 300                 


Met Ala Thr Val Thr Ala Leu Arg Arg Thr Val Pro Pro Ala Val Thr 
305                 310                 315                 320 


Gly Ile Thr Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile 
                325                 330                 335     


Asn Leu Asn Ala Ile Asn Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu 
            340                 345                 350         


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp 
        355                 360                 365             


Gly Gly Lys Lys Glu Asn Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys 
    370                 375                 380                 


Arg Ala Leu Ala Asn Ser Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser 
385                 390                 395                 400 


Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His 
                405                 410                 415     


Ala Tyr 
        


<210>  443
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDOB__Homo_sapiens__NP_000026

<400>  443

Met Ala His Arg Phe Pro Ala Leu Thr Gln Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Glu Ile Ala Gln Ser Ile Val Ala Asn Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Val Gly Thr Met Gly Asn Arg Leu Gln Arg Ile Lys 
        35                  40                  45              


Val Glu Asn Thr Glu Glu Asn Arg Arg Gln Phe Arg Glu Ile Leu Phe 
    50                  55                  60                  


Ser Val Asp Ser Ser Ile Asn Gln Ser Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Asp Ser Gln Gly Lys Leu Phe Arg Asn 
                85                  90                  95      


Ile Leu Lys Glu Lys Gly Ile Val Val Gly Ile Lys Leu Asp Gln Gly 
            100                 105                 110         


Gly Ala Pro Leu Ala Gly Thr Asn Lys Glu Thr Thr Ile Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Val Asp 
    130                 135                 140                 


Phe Gly Lys Trp Arg Ala Val Leu Arg Ile Ala Asp Gln Cys Pro Ser 
145                 150                 155                 160 


Ser Leu Ala Ile Gln Glu Asn Ala Asn Ala Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Leu Val Pro Ile Val Glu Pro Glu Val Ile 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Glu His Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Asn Asp His His Val Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Ala Gly His Ala Cys 
225                 230                 235                 240 


Thr Lys Lys Tyr Thr Pro Glu Gln Val Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu His Arg Thr Val Pro Ala Ala Val Pro Gly Ile Cys Phe Leu Ser 
            260                 265                 270         


Gly Gly Met Ser Glu Glu Asp Ala Thr Leu Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Leu Cys Pro Leu Pro Lys Pro Trp Lys Leu Ser Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Ala Ala Trp Gly Gly Lys Ala Ala Asn 
305                 310                 315                 320 


Lys Glu Ala Thr Gln Glu Ala Phe Met Lys Arg Ala Met Ala Asn Cys 
                325                 330                 335     


Gln Ala Ala Lys Gly Gln Tyr Val His Thr Gly Ser Ser Gly Ala Ala 
            340                 345                 350         


Ser Thr Gln Ser Leu Phe Thr Ala Cys Tyr Thr Tyr 
        355                 360                 


<210>  444
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALDOC__Homo_sapiens__NP_005156

<400>  444

Met Pro His Ser Tyr Pro Ala Leu Ser Ala Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala Leu Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Val Gly Ser Met Ala Lys Arg Leu Ser Gln Ile Gly 
        35                  40                  45              


Val Glu Asn Thr Glu Glu Asn Arg Arg Leu Tyr Arg Gln Val Leu Phe 
    50                  55                  60                  


Ser Ala Asp Asp Arg Val Lys Lys Cys Ile Gly Gly Val Ile Phe Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Asp Asp Asn Gly Val Pro Phe Val Arg 
                85                  90                  95      


Thr Ile Gln Asp Lys Gly Ile Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asp Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Ser Glu Arg Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Leu Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Val Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Pro Ile Lys Tyr Thr Pro Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Pro Gly Val Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Phe Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Arg Cys Pro Leu Pro Arg Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Asn Ala Trp Arg Gly Gln Arg Asp Asn 
305                 310                 315                 320 


Ala Gly Ala Ala Thr Glu Glu Phe Ile Lys Arg Ala Glu Val Asn Gly 
                325                 330                 335     


Leu Ala Ala Gln Gly Lys Tyr Glu Gly Ser Gly Glu Asp Gly Gly Ala 
            340                 345                 350         


Ala Ala Gln Ser Leu Tyr Ile Ala Asn His Ala Tyr 
        355                 360                 


<210>  445
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG10B__Homo_sapiens__NP_001013642

<400>  445

Met Ala Gln Leu Glu Gly Tyr Cys Phe Ser Ala Ala Leu Ser Cys Thr 
1               5                   10                  15      


Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Arg Ala Leu Arg 
            20                  25                  30          


Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln Arg Tyr 
        35                  40                  45              


Cys Glu Gly His Phe Ser Leu Ser Gln Trp Asp Pro Met Ile Thr Thr 
    50                  55                  60                  


Leu Pro Gly Leu Tyr Leu Val Ser Val Gly Val Val Lys Pro Ala Ile 
65                  70                  75                  80  


Trp Ile Phe Gly Trp Ser Glu His Val Val Cys Ser Ile Gly Met Leu 
                85                  90                  95      


Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe Tyr Leu Leu Tyr 
            100                 105                 110         


Leu Leu Phe His Lys Val Gln Pro Arg Asn Lys Ala Ala Ser Ser Ile 
        115                 120                 125             


Gln Arg Val Leu Ser Thr Leu Thr Leu Ala Val Phe Pro Thr Leu Tyr 
    130                 135                 140                 


Phe Phe Asn Phe Leu Tyr Tyr Thr Glu Ala Gly Ser Met Phe Phe Thr 
145                 150                 155                 160 


Leu Phe Ala Tyr Leu Met Cys Leu Tyr Gly Asn His Lys Thr Ser Ala 
                165                 170                 175     


Phe Leu Gly Phe Cys Gly Phe Met Phe Arg Gln Thr Asn Ile Ile Trp 
            180                 185                 190         


Ala Val Phe Cys Ala Gly Asn Val Ile Ala Gln Lys Leu Thr Glu Ala 
        195                 200                 205             


Trp Lys Thr Glu Leu Gln Lys Lys Glu Asp Arg Leu Pro Pro Ile Lys 
    210                 215                 220                 


Gly Pro Phe Ala Glu Phe Arg Lys Ile Leu Gln Phe Leu Leu Ala Tyr 
225                 230                 235                 240 


Ser Met Ser Phe Lys Asn Leu Ser Met Leu Phe Cys Leu Thr Trp Pro 
                245                 250                 255     


Tyr Ile Leu Leu Gly Phe Leu Phe Cys Ala Phe Val Val Val Asn Gly 
            260                 265                 270         


Gly Ile Val Ile Gly Asp Arg Ser Ser His Glu Ala Cys Leu His Phe 
        275                 280                 285             


Pro Gln Leu Phe Tyr Phe Phe Ser Phe Thr Leu Phe Phe Ser Phe Pro 
    290                 295                 300                 


His Leu Leu Ser Pro Ser Lys Ile Lys Thr Phe Leu Ser Leu Val Trp 
305                 310                 315                 320 


Lys His Gly Ile Leu Phe Leu Val Val Thr Leu Val Ser Val Phe Leu 
                325                 330                 335     


Val Trp Lys Phe Thr Tyr Ala His Lys Tyr Leu Leu Ala Asp Asn Arg 
            340                 345                 350         


His Tyr Thr Phe Tyr Val Trp Lys Arg Val Phe Gln Arg Tyr Ala Ile 
        355                 360                 365             


Leu Lys Tyr Leu Leu Val Pro Ala Tyr Ile Phe Ala Gly Trp Ser Ile 
    370                 375                 380                 


Ala Asp Ser Leu Lys Ser Lys Pro Ile Phe Trp Asn Leu Met Phe Phe 
385                 390                 395                 400 


Ile Cys Leu Phe Ile Val Ile Val Pro Gln Lys Leu Leu Glu Phe Arg 
                405                 410                 415     


Tyr Phe Ile Leu Pro Tyr Val Ile Tyr Arg Leu Asn Ile Thr Leu Pro 
            420                 425                 430         


Pro Thr Ser Arg Leu Val Cys Glu Leu Ser Cys Tyr Ala Ile Val Asn 
        435                 440                 445             


Phe Ile Thr Phe Tyr Ile Phe Leu Asn Lys Thr Phe Gln Trp Pro Asn 
    450                 455                 460                 


Ser Gln Asp Ile Gln Arg Phe Met Trp 
465                 470             


<210>  446
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG10__Homo_sapiens__NP_116223

<400>  446

Met Ala Gln Leu Glu Gly Tyr Tyr Phe Ser Ala Ala Leu Ser Cys Thr 
1               5                   10                  15      


Phe Leu Val Ser Cys Leu Leu Phe Ser Ala Phe Ser Arg Ala Leu Arg 
            20                  25                  30          


Glu Pro Tyr Met Asp Glu Ile Phe His Leu Pro Gln Ala Gln Arg Tyr 
        35                  40                  45              


Cys Glu Gly His Phe Ser Leu Ser Gln Trp Asp Pro Met Ile Thr Thr 
    50                  55                  60                  


Leu Pro Gly Leu Tyr Leu Val Ser Ile Gly Val Ile Lys Pro Ala Ile 
65                  70                  75                  80  


Trp Ile Phe Gly Trp Ser Glu His Val Val Cys Ser Ile Gly Met Leu 
                85                  90                  95      


Arg Phe Val Asn Leu Leu Phe Ser Val Gly Asn Phe Tyr Leu Leu Tyr 
            100                 105                 110         


Leu Leu Phe Cys Lys Val Gln Pro Arg Asn Lys Ala Ala Ser Ser Ile 
        115                 120                 125             


Gln Arg Val Leu Ser Thr Leu Thr Leu Ala Val Phe Pro Thr Leu Tyr 
    130                 135                 140                 


Phe Phe Asn Phe Leu Tyr Tyr Thr Glu Ala Gly Ser Met Phe Phe Thr 
145                 150                 155                 160 


Leu Phe Ala Tyr Leu Met Cys Leu Tyr Gly Asn His Lys Thr Ser Ala 
                165                 170                 175     


Phe Leu Gly Phe Cys Gly Phe Met Phe Arg Gln Thr Asn Ile Ile Trp 
            180                 185                 190         


Ala Val Phe Cys Ala Gly Asn Val Ile Ala Gln Lys Leu Thr Glu Ala 
        195                 200                 205             


Trp Lys Thr Glu Leu Gln Lys Lys Glu Asp Arg Leu Pro Pro Ile Lys 
    210                 215                 220                 


Gly Pro Phe Ala Glu Phe Arg Lys Ile Leu Gln Phe Leu Leu Ala Tyr 
225                 230                 235                 240 


Ser Met Ser Phe Lys Asn Leu Ser Met Leu Leu Leu Leu Thr Trp Pro 
                245                 250                 255     


Tyr Ile Leu Leu Gly Phe Leu Phe Cys Ala Phe Val Val Val Asn Gly 
            260                 265                 270         


Gly Ile Val Ile Gly Asp Arg Ser Ser His Glu Ala Cys Leu His Phe 
        275                 280                 285             


Pro Gln Leu Phe Tyr Phe Phe Ser Phe Thr Leu Phe Phe Ser Phe Pro 
    290                 295                 300                 


His Leu Leu Ser Pro Ser Lys Ile Lys Thr Phe Leu Ser Leu Val Trp 
305                 310                 315                 320 


Lys Arg Arg Ile Leu Phe Phe Val Val Thr Leu Val Ser Val Phe Leu 
                325                 330                 335     


Val Trp Lys Phe Thr Tyr Ala His Lys Tyr Leu Leu Ala Asp Asn Arg 
            340                 345                 350         


His Tyr Thr Phe Tyr Val Trp Lys Arg Val Phe Gln Arg Tyr Glu Thr 
        355                 360                 365             


Val Lys Tyr Leu Leu Val Pro Ala Tyr Ile Phe Ala Gly Trp Ser Ile 
    370                 375                 380                 


Ala Asp Ser Leu Lys Ser Lys Ser Ile Phe Trp Asn Leu Met Phe Phe 
385                 390                 395                 400 


Ile Cys Leu Phe Thr Val Ile Val Pro Gln Lys Leu Leu Glu Phe Arg 
                405                 410                 415     


Tyr Phe Ile Leu Pro Tyr Val Ile Tyr Arg Leu Asn Ile Pro Leu Pro 
            420                 425                 430         


Pro Thr Ser Arg Leu Ile Cys Glu Leu Ser Cys Tyr Ala Val Val Asn 
        435                 440                 445             


Phe Ile Thr Phe Phe Ile Phe Leu Asn Lys Thr Phe Gln Trp Pro Asn 
    450                 455                 460                 


Ser Gln Asp Ile Gln Arg Phe Met Trp 
465                 470             


<210>  447
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG11__Homo_sapiens__NP_001004127

<400>  447

Met Ala Ala Gly Glu Arg Ser Trp Cys Leu Cys Lys Leu Leu Arg Phe 
1               5                   10                  15      


Phe Tyr Ser Leu Phe Phe Pro Gly Leu Ile Val Cys Gly Thr Leu Cys 
            20                  25                  30          


Val Cys Leu Val Ile Val Leu Trp Gly Ile Arg Leu Leu Leu Gln Arg 
        35                  40                  45              


Lys Lys Lys Leu Val Ser Thr Ser Lys Asn Gly Lys Asn Gln Met Val 
    50                  55                  60                  


Ile Ala Phe Phe His Pro Tyr Cys Asn Ala Gly Gly Gly Gly Glu Arg 
65                  70                  75                  80  


Val Leu Trp Cys Ala Leu Arg Ala Leu Gln Lys Lys Tyr Pro Glu Ala 
                85                  90                  95      


Val Tyr Val Val Tyr Thr Gly Asp Val Asn Val Asn Gly Gln Gln Ile 
            100                 105                 110         


Leu Glu Gly Ala Phe Arg Arg Phe Asn Ile Arg Leu Ile His Pro Val 
        115                 120                 125             


Gln Phe Val Phe Leu Arg Lys Arg Tyr Leu Val Glu Asp Ser Leu Tyr 
    130                 135                 140                 


Pro His Phe Thr Leu Leu Gly Gln Ser Leu Gly Ser Ile Phe Leu Gly 
145                 150                 155                 160 


Trp Glu Ala Leu Met Gln Cys Val Pro Asp Val Tyr Ile Asp Ser Met 
                165                 170                 175     


Gly Tyr Ala Phe Thr Leu Pro Leu Phe Lys Tyr Ile Gly Gly Cys Gln 
            180                 185                 190         


Val Gly Ser Tyr Val His Tyr Pro Thr Ile Ser Thr Asp Met Leu Ser 
        195                 200                 205             


Val Val Lys Asn Gln Asn Ile Gly Phe Asn Asn Ala Ala Phe Ile Thr 
    210                 215                 220                 


Arg Asn Pro Phe Leu Ser Lys Val Lys Leu Ile Tyr Tyr Tyr Leu Phe 
225                 230                 235                 240 


Ala Phe Ile Tyr Gly Leu Val Gly Ser Cys Ser Asp Val Val Met Val 
                245                 250                 255     


Asn Ser Ser Trp Thr Leu Asn His Ile Leu Ser Leu Trp Lys Val Gly 
            260                 265                 270         


Asn Cys Thr Asn Ile Val Tyr Pro Pro Cys Asp Val Gln Thr Phe Leu 
        275                 280                 285             


Asp Ile Pro Leu His Glu Lys Lys Met Thr Pro Gly His Leu Leu Val 
    290                 295                 300                 


Ser Val Gly Gln Phe Arg Pro Glu Lys Asn His Pro Leu Gln Ile Arg 
305                 310                 315                 320 


Ala Phe Ala Lys Leu Leu Asn Lys Lys Met Val Glu Ser Pro Pro Ser 
                325                 330                 335     


Leu Lys Leu Val Leu Ile Gly Gly Cys Arg Asn Lys Asp Asp Glu Leu 
            340                 345                 350         


Arg Val Asn Gln Leu Arg Arg Leu Ser Glu Asp Leu Gly Val Gln Glu 
        355                 360                 365             


Tyr Val Glu Phe Lys Ile Asn Ile Pro Phe Asp Glu Leu Lys Asn Tyr 
    370                 375                 380                 


Leu Ser Glu Ala Thr Ile Gly Leu His Thr Met Trp Asn Glu His Phe 
385                 390                 395                 400 


Gly Ile Gly Val Val Glu Cys Met Ala Ala Gly Thr Ile Ile Leu Ala 
                405                 410                 415     


His Asn Ser Gly Gly Pro Lys Leu Asp Ile Val Val Pro His Glu Gly 
            420                 425                 430         


Asp Ile Thr Gly Phe Leu Ala Glu Ser Glu Glu Asp Tyr Ala Glu Thr 
        435                 440                 445             


Ile Ala His Ile Leu Ser Met Ser Ala Glu Lys Arg Leu Gln Ile Arg 
    450                 455                 460                 


Lys Ser Ala Arg Ala Ser Val Ser Arg Phe Ser Asp Gln Glu Phe Glu 
465                 470                 475                 480 


Val Thr Phe Leu Ser Ser Val Glu Lys Leu Phe Lys 
                485                 490         


<210>  448
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG12__Homo_sapiens__NP_077010

<400>  448

Met Ala Gly Lys Gly Ser Ser Gly Arg Arg Pro Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Ala Val Ala Thr Val His Leu Val Ile Cys Pro Tyr Thr Lys 
            20                  25                  30          


Val Glu Glu Ser Phe Asn Leu Gln Ala Thr His Asp Leu Leu Tyr His 
        35                  40                  45              


Trp Gln Asp Leu Glu Gln Tyr Asp His Leu Glu Phe Pro Gly Val Val 
    50                  55                  60                  


Pro Arg Thr Phe Leu Gly Pro Val Val Ile Ala Val Phe Ser Ser Pro 
65                  70                  75                  80  


Ala Val Tyr Val Leu Ser Leu Leu Glu Met Ser Lys Phe Tyr Ser Gln 
                85                  90                  95      


Leu Ile Val Arg Gly Val Leu Gly Leu Gly Val Ile Phe Gly Leu Trp 
            100                 105                 110         


Thr Leu Gln Lys Glu Val Arg Arg His Phe Gly Ala Met Val Ala Thr 
        115                 120                 125             


Met Phe Cys Trp Val Thr Ala Met Gln Phe His Leu Met Phe Tyr Cys 
    130                 135                 140                 


Thr Arg Thr Leu Pro Asn Val Leu Ala Leu Pro Val Val Leu Leu Ala 
145                 150                 155                 160 


Leu Ala Ala Trp Leu Arg His Glu Trp Ala Arg Phe Ile Trp Leu Ser 
                165                 170                 175     


Ala Phe Ala Ile Ile Val Phe Arg Val Glu Leu Cys Leu Phe Leu Gly 
            180                 185                 190         


Leu Leu Leu Leu Leu Ala Leu Gly Asn Arg Lys Val Ser Val Val Arg 
        195                 200                 205             


Ala Leu Arg His Ala Val Pro Ala Gly Ile Leu Cys Leu Gly Leu Thr 
    210                 215                 220                 


Val Ala Val Asp Ser Tyr Phe Trp Arg Gln Leu Thr Trp Pro Glu Gly 
225                 230                 235                 240 


Lys Val Leu Trp Tyr Asn Thr Val Leu Asn Lys Ser Ser Asn Trp Gly 
                245                 250                 255     


Thr Ser Pro Leu Leu Trp Tyr Phe Tyr Ser Ala Leu Pro Arg Gly Leu 
            260                 265                 270         


Gly Cys Ser Leu Leu Phe Ile Pro Leu Gly Leu Val Asp Arg Arg Thr 
        275                 280                 285             


His Ala Pro Thr Val Leu Ala Leu Gly Phe Met Ala Leu Tyr Ser Leu 
    290                 295                 300                 


Leu Pro His Lys Glu Leu Arg Phe Ile Ile Tyr Ala Phe Pro Met Leu 
305                 310                 315                 320 


Asn Ile Thr Ala Ala Arg Gly Cys Ser Tyr Leu Leu Asn Asn Tyr Lys 
                325                 330                 335     


Lys Ser Trp Leu Tyr Lys Ala Gly Ser Leu Leu Val Ile Gly His Leu 
            340                 345                 350         


Val Val Asn Ala Ala Tyr Ser Ala Thr Ala Leu Tyr Val Ser His Phe 
        355                 360                 365             


Asn Tyr Pro Gly Gly Val Ala Met Gln Arg Leu His Gln Leu Val Pro 
    370                 375                 380                 


Pro Gln Thr Asp Val Leu Leu His Ile Asp Val Ala Ala Ala Gln Thr 
385                 390                 395                 400 


Gly Val Ser Arg Phe Leu Gln Val Asn Ser Ala Trp Arg Tyr Asp Lys 
                405                 410                 415     


Arg Glu Asp Val Gln Pro Gly Thr Gly Met Leu Ala Tyr Thr His Ile 
            420                 425                 430         


Leu Met Glu Ala Ala Pro Gly Leu Leu Ala Leu Tyr Arg Asp Thr His 
        435                 440                 445             


Arg Val Leu Ala Ser Val Val Gly Thr Thr Gly Val Ser Leu Asn Leu 
    450                 455                 460                 


Thr Gln Leu Pro Pro Phe Asn Val His Leu Gln Thr Lys Leu Val Leu 
465                 470                 475                 480 


Leu Glu Arg Leu Pro Arg Pro Ser 
                485             


<210>  449
<211>  1137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG13__Homo_sapiens__NP_001093392

<400>  449

Met Lys Cys Val Phe Val Thr Val Gly Thr Thr Ser Phe Asp Asp Leu 
1               5                   10                  15      


Ile Ala Cys Val Ser Ala Pro Asp Ser Leu Gln Lys Ile Glu Ser Leu 
            20                  25                  30          


Gly Tyr Asn Arg Leu Ile Leu Gln Ile Gly Arg Gly Thr Val Val Pro 
        35                  40                  45              


Glu Pro Phe Ser Thr Glu Ser Phe Thr Leu Asp Val Tyr Arg Tyr Lys 
    50                  55                  60                  


Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu Val Ile Ser His 
65                  70                  75                  80  


Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys Gly Lys Pro Leu 
                85                  90                  95      


Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His Gln Leu Glu Leu 
            100                 105                 110         


Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr Cys Thr Cys Arg 
        115                 120                 125             


Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala Ser Ala Pro Gly 
    130                 135                 140                 


Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala Phe Ser Gly Leu 
145                 150                 155                 160 


Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln Ala Leu Val Thr 
                165                 170                 175     


Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser Cys His Ala Phe 
            180                 185                 190         


Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met His Lys Gly Trp 
        195                 200                 205             


Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala Ser Met Asp Glu 
    210                 215                 220                 


Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr Ala Lys Asp Ala 
225                 230                 235                 240 


Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe Cys Ser Gln Val 
                245                 250                 255     


His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr Met Arg Glu Asn 
            260                 265                 270         


Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe Glu Lys Tyr Leu 
        275                 280                 285             


Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln Leu Glu Ile Arg 
    290                 295                 300                 


Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu Tyr Arg Phe Pro 
305                 310                 315                 320 


Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr Glu Asp Lys Ile 
                325                 330                 335     


Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser Val Tyr Ser Lys 
            340                 345                 350         


Gln Phe Gln Ser Ser Ala Ala Val Cys Gln Ala Val Leu Tyr Glu Ile 
        355                 360                 365             


Leu Tyr Lys Asp Val Phe Val Val Asp Glu Glu Glu Leu Lys Thr Ala 
    370                 375                 380                 


Ile Lys Leu Phe Arg Ser Gly Ser Lys Lys Asn Arg Asn Asn Ala Val 
385                 390                 395                 400 


Thr Gly Ser Glu Asp Ala His Thr Asp Tyr Lys Ser Ser Asn Gln Asn 
                405                 410                 415     


Arg Met Glu Glu Trp Gly Ala Cys Tyr Asn Ala Glu Asn Ile Pro Glu 
            420                 425                 430         


Gly Tyr Asn Lys Gly Thr Glu Glu Thr Lys Ser Pro Glu Asn Pro Ser 
        435                 440                 445             


Lys Met Pro Phe Pro Tyr Lys Val Leu Lys Ala Leu Asp Pro Glu Ile 
    450                 455                 460                 


Tyr Arg Asn Val Glu Phe Asp Val Trp Leu Asp Ser Arg Lys Glu Leu 
465                 470                 475                 480 


Gln Lys Ser Asp Tyr Met Glu Tyr Ala Gly Arg Gln Tyr Tyr Leu Gly 
                485                 490                 495     


Asp Lys Cys Gln Val Cys Leu Glu Ser Glu Gly Arg Tyr Tyr Asn Ala 
            500                 505                 510         


His Ile Gln Glu Val Gly Asn Glu Asn Asn Ser Val Thr Val Phe Ile 
        515                 520                 525             


Glu Glu Leu Ala Glu Lys His Val Val Pro Leu Ala Asn Leu Lys Pro 
    530                 535                 540                 


Val Thr Gln Val Met Ser Val Pro Ala Trp Asn Ala Met Pro Ser Arg 
545                 550                 555                 560 


Lys Gly Arg Gly Tyr Gln Lys Met Pro Gly Gly Tyr Val Pro Glu Ile 
                565                 570                 575     


Val Ile Ser Glu Met Asp Ile Lys Gln Gln Lys Lys Met Phe Lys Lys 
            580                 585                 590         


Ile Arg Gly Lys Glu Val Tyr Met Thr Met Ala Tyr Gly Lys Gly Asp 
        595                 600                 605             


Pro Leu Leu Pro Pro Arg Leu Gln His Ser Met His Tyr Gly His Asp 
    610                 615                 620                 


Pro Pro Met His Tyr Ser Gln Thr Ala Gly Asn Val Met Ser Asn Glu 
625                 630                 635                 640 


His Phe His Pro Gln His Pro Ser Pro Arg Gln Gly Arg Gly Tyr Gly 
                645                 650                 655     


Met Pro Arg Asn Ser Ser Arg Phe Ile Asn Arg His Asn Met Pro Gly 
            660                 665                 670         


Pro Lys Val Asp Phe Tyr Pro Gly Pro Gly Lys Arg Cys Cys Gln Ser 
        675                 680                 685             


Tyr Asp Asn Phe Ser Tyr Arg Ser Arg Ser Phe Arg Arg Ser His Arg 
    690                 695                 700                 


Gln Met Ser Cys Val Asn Lys Glu Ser Gln Tyr Gly Phe Thr Pro Gly 
705                 710                 715                 720 


Asn Gly Gln Met Pro Arg Gly Leu Glu Glu Thr Ile Thr Phe Tyr Glu 
                725                 730                 735     


Val Glu Glu Gly Asp Glu Thr Ala Tyr Pro Thr Leu Pro Asn His Gly 
            740                 745                 750         


Gly Pro Ser Thr Met Val Pro Ala Thr Ser Gly Tyr Cys Val Gly Arg 
        755                 760                 765             


Arg Gly His Ser Ser Gly Lys Gln Thr Leu Asn Leu Glu Glu Gly Asn 
    770                 775                 780                 


Gly Gln Ser Glu Asn Gly Arg Tyr His Glu Glu Tyr Leu Tyr Arg Ala 
785                 790                 795                 800 


Glu Pro Asp Tyr Glu Thr Ser Gly Val Tyr Ser Thr Thr Ala Ser Thr 
                805                 810                 815     


Ala Asn Leu Ser Leu Gln Asp Arg Lys Ser Cys Ser Met Ser Pro Gln 
            820                 825                 830         


Asp Thr Val Thr Ser Tyr Asn Tyr Pro Gln Lys Met Met Gly Asn Ile 
        835                 840                 845             


Ala Ala Val Ala Ala Ser Cys Ala Asn Asn Val Pro Ala Pro Val Leu 
    850                 855                 860                 


Ser Asn Gly Ala Ala Ala Asn Gln Ala Ile Ser Thr Thr Ser Val Ser 
865                 870                 875                 880 


Ser Gln Asn Ala Ile Gln Pro Leu Phe Val Ser Pro Pro Thr His Gly 
                885                 890                 895     


Arg Pro Val Ile Ala Ser Pro Ser Tyr Pro Cys His Ser Ala Ile Pro 
            900                 905                 910         


His Ala Gly Ala Ser Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    930                 935                 940                 


Pro Ala Leu Asp Val Gly Glu Thr Ser Asn Leu Gln Pro Pro Pro Pro 
945                 950                 955                 960 


Leu Pro Pro Pro Pro Tyr Ser Cys Asp Pro Ser Gly Ser Asp Leu Pro 
                965                 970                 975     


Gln Asp Thr Lys Val Leu Gln Tyr Tyr Phe Asn Leu Gly Leu Gln Cys 
            980                 985                 990         


Tyr Tyr His Ser Tyr Trp His Ser  Met Val Tyr Val Pro  Gln Met Gln 
        995                 1000                 1005             


Gln Gln  Leu His Val Glu Asn  Tyr Pro Val Tyr Thr  Glu Pro Pro 
    1010                 1015                 1020             


Leu Val  Asp Gln Thr Val Pro  Gln Cys Tyr Ser Glu  Val Arg Arg 
    1025                 1030                 1035             


Glu Asp  Gly Ile Gln Ala Glu  Ala Ser Ala Asn Asp  Thr Phe Pro 
    1040                 1045                 1050             


Asn Ala  Asp Ser Ser Ser Val  Pro His Gly Ala Val  Tyr Tyr Pro 
    1055                 1060                 1065             


Val Met  Ser Asp Pro Tyr Gly  Gln Pro Pro Leu Pro  Gly Phe Asp 
    1070                 1075                 1080             


Ser Cys  Leu Pro Val Val Pro  Asp Tyr Ser Cys Val  Pro Pro Trp 
    1085                 1090                 1095             


His Pro  Val Gly Thr Ala Tyr  Gly Gly Ser Ser Gln  Ile His Gly 
    1100                 1105                 1110             


Ala Ile  Asn Pro Gly Pro Ile  Gly Cys Ile Ala Pro  Ser Pro Pro 
    1115                 1120                 1125             


Ala Ser  His Tyr Val Pro Gln  Gly Met 
    1130                 1135         


<210>  450
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG1__Homo_sapiens__NP_061982

<400>  450

Met Ala Ala Ser Cys Leu Val Leu Leu Ala Leu Cys Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Gly Gly Trp Lys Arg Trp Arg Arg Gly Arg Ala Ala 
            20                  25                  30          


Arg His Val Val Ala Val Val Leu Gly Asp Val Gly Arg Ser Pro Arg 
        35                  40                  45              


Met Gln Tyr His Ala Leu Ser Leu Ala Met His Gly Phe Ser Val Thr 
    50                  55                  60                  


Leu Leu Gly Phe Cys Asn Ser Lys Pro His Asp Glu Leu Leu Gln Asn 
65                  70                  75                  80  


Asn Arg Ile Gln Ile Val Gly Leu Thr Glu Leu Gln Ser Leu Ala Val 
                85                  90                  95      


Gly Pro Arg Val Phe Gln Tyr Gly Val Lys Val Val Leu Gln Ala Met 
            100                 105                 110         


Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile Phe 
        115                 120                 125             


Leu Gln Asn Pro Pro Gly Leu Pro Ser Ile Ala Val Cys Trp Phe Val 
    130                 135                 140                 


Gly Cys Leu Cys Gly Ser Lys Leu Val Ile Asp Trp His Asn Tyr Gly 
145                 150                 155                 160 


Tyr Ser Ile Met Gly Leu Val His Gly Pro Asn His Pro Leu Val Leu 
                165                 170                 175     


Leu Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu Asn 
            180                 185                 190         


Leu Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp His 
        195                 200                 205             


Ile Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys Glu 
    210                 215                 220                 


Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser Met 
225                 230                 235                 240 


His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr Glu 
                245                 250                 255     


Arg Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr Arg 
            260                 265                 270         


Leu Arg Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr Glu 
        275                 280                 285             


Asp Glu Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Lys Phe Glu Gln 
    290                 295                 300                 


Leu Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile Thr 
305                 310                 315                 320 


Gly Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu Ile His Gln Lys 
                325                 330                 335     


His Phe Gln His Ile Gln Val Cys Thr Pro Trp Leu Glu Ala Glu Asp 
            340                 345                 350         


Tyr Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His Thr 
        355                 360                 365             


Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Gly 
    370                 375                 380                 


Cys Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu Leu 
385                 390                 395                 400 


Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu Leu 
                405                 410                 415     


Ala Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly 
            420                 425                 430         


Lys Leu Asn Gln Phe Arg Lys Asn Leu Arg Glu Ser Gln Gln Leu Arg 
        435                 440                 445             


Trp Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp Thr 
    450                 455                 460                 


<210>  451
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG1L__Homo_sapiens__NP_001015050

<400>  451

Met Glu Arg Ser Ala Phe Met Glu Leu Asp Ala Gly Ser Arg Leu Val 
1               5                   10                  15      


Met His Leu Arg Glu Trp Pro Ala Leu Leu Val Ser Ser Thr Gly Trp 
            20                  25                  30          


Thr Glu Phe Glu Gln Leu Thr Leu Asp Gly His Asn Leu Pro Ser Leu 
        35                  40                  45              


Val Cys Val Ile Thr Gly Ser Val Asp Leu Gly Val Cys Leu His Met 
    50                  55                  60                  


Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Gly 
65                  70                  75                  80  


Cys Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu Leu 
                85                  90                  95      


Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu Leu 
            100                 105                 110         


Ala Ala Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly Lys 
        115                 120                 125             


Leu Asn Gln Phe Trp Lys Asn Leu Arg Glu Ser Gln Gln Leu Arg Trp 
    130                 135                 140                 


Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp Ile Gln 
145                 150                 155                 160 


Leu Leu Gly Gln Arg Leu Lys Pro Arg Asp Pro Cys Cys Pro Ser Arg 
                165                 170                 175     


Ser Phe Phe Ser Glu Ser Gln Gly Lys Pro Phe 
            180                 185         


<210>  452
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG2__Homo_sapiens__NP_149078

<400>  452

Met Ala Glu Glu Gln Gly Arg Glu Arg Asp Ser Val Pro Lys Pro Ser 
1               5                   10                  15      


Val Leu Phe Leu His Pro Asp Leu Gly Val Gly Gly Ala Glu Arg Leu 
            20                  25                  30          


Val Leu Asp Ala Ala Leu Ala Leu Gln Ala Arg Gly Cys Ser Val Lys 
        35                  40                  45              


Ile Trp Thr Ala His Tyr Asp Pro Gly His Cys Phe Ala Glu Ser Arg 
    50                  55                  60                  


Glu Leu Pro Val Arg Cys Ala Gly Asp Trp Leu Pro Arg Gly Leu Gly 
65                  70                  75                  80  


Trp Gly Gly Arg Gly Ala Ala Val Cys Ala Tyr Val Arg Met Val Phe 
                85                  90                  95      


Leu Ala Leu Tyr Val Leu Phe Leu Ala Asp Glu Glu Phe Asp Val Val 
            100                 105                 110         


Val Cys Asp Gln Val Ser Ala Cys Ile Pro Val Phe Arg Leu Ala Arg 
        115                 120                 125             


Arg Arg Lys Lys Ile Leu Phe Tyr Cys His Phe Pro Asp Leu Leu Leu 
    130                 135                 140                 


Thr Lys Arg Asp Ser Phe Leu Lys Arg Leu Tyr Arg Ala Pro Ile Asp 
145                 150                 155                 160 


Trp Ile Glu Glu Tyr Thr Thr Gly Met Ala Asp Cys Ile Leu Val Asn 
                165                 170                 175     


Ser Gln Phe Thr Ala Ala Val Phe Lys Glu Thr Phe Lys Ser Leu Ser 
            180                 185                 190         


His Ile Asp Pro Asp Val Leu Tyr Pro Ser Leu Asn Val Thr Ser Phe 
        195                 200                 205             


Asp Ser Val Val Pro Glu Lys Leu Asp Asp Leu Val Pro Lys Gly Lys 
    210                 215                 220                 


Lys Phe Leu Leu Leu Ser Ile Asn Arg Tyr Glu Arg Lys Lys Asn Leu 
225                 230                 235                 240 


Thr Leu Ala Leu Glu Ala Leu Val Gln Leu Arg Gly Arg Leu Thr Ser 
                245                 250                 255     


Gln Asp Trp Glu Arg Val His Leu Ile Val Ala Gly Gly Tyr Asp Glu 
            260                 265                 270         


Arg Val Leu Glu Asn Val Glu His Tyr Gln Glu Leu Lys Lys Met Val 
        275                 280                 285             


Gln Gln Ser Asp Leu Gly Gln Tyr Val Thr Phe Leu Arg Ser Phe Ser 
    290                 295                 300                 


Asp Lys Gln Lys Ile Ser Leu Leu His Ser Cys Thr Cys Val Leu Tyr 
305                 310                 315                 320 


Thr Pro Ser Asn Glu His Phe Gly Ile Val Pro Leu Glu Ala Met Tyr 
                325                 330                 335     


Met Gln Cys Pro Val Ile Ala Val Asn Ser Gly Gly Pro Leu Glu Ser 
            340                 345                 350         


Ile Asp His Ser Val Thr Gly Phe Leu Cys Glu Pro Asp Pro Val His 
        355                 360                 365             


Phe Ser Glu Ala Ile Glu Lys Phe Ile Arg Glu Pro Ser Leu Lys Ala 
    370                 375                 380                 


Thr Met Gly Leu Ala Gly Arg Ala Arg Val Lys Glu Lys Phe Ser Pro 
385                 390                 395                 400 


Glu Ala Phe Thr Glu Gln Leu Tyr Arg Tyr Val Thr Lys Leu Leu Val 
                405                 410                 415     


<210>  453
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG3__Homo_sapiens__NP_001006942

<400>  453

Met Phe Pro Ala Gln Ala Lys Glu Asn Ala Gly Phe Ser Gly Cys Gly 
1               5                   10                  15      


Gly Asp Thr Glu Ile Asp Trp Lys Ala Tyr Met Ala Glu Val Glu Gly 
            20                  25                  30          


Val Ile Asn Gly Thr Tyr Asp Tyr Thr Gln Leu Gln Gly Asp Thr Gly 
        35                  40                  45              


Pro Leu Val Tyr Pro Ala Gly Phe Val Tyr Ile Phe Met Gly Leu Tyr 
    50                  55                  60                  


Tyr Ala Thr Ser Arg Gly Thr Asp Ile Arg Met Ala Gln Asn Ile Phe 
65                  70                  75                  80  


Ala Val Leu Tyr Leu Ala Thr Leu Leu Leu Val Phe Leu Ile Tyr His 
                85                  90                  95      


Gln Thr Cys Lys Val Pro Pro Phe Val Phe Phe Phe Met Cys Cys Ala 
            100                 105                 110         


Ser Tyr Arg Val His Ser Ile Phe Val Leu Arg Leu Phe Asn Asp Pro 
        115                 120                 125             


Val Ala Met Val Leu Leu Phe Leu Ser Ile Asn Leu Leu Leu Ala Gln 
    130                 135                 140                 


Arg Trp Gly Trp Gly Cys Cys Phe Phe Ser Leu Ala Val Ser Val Lys 
145                 150                 155                 160 


Met Asn Val Leu Leu Phe Ala Pro Gly Leu Leu Phe Leu Leu Leu Thr 
                165                 170                 175     


Gln Phe Gly Phe Arg Gly Ala Leu Pro Lys Leu Gly Ile Cys Ala Gly 
            180                 185                 190         


Leu Gln Val Val Leu Gly Leu Pro Phe Leu Leu Glu Asn Pro Ser Gly 
        195                 200                 205             


Tyr Leu Ser Arg Ser Phe Asp Leu Gly Arg Gln Phe Leu Phe His Trp 
    210                 215                 220                 


Thr Val Asn Trp Arg Phe Leu Pro Glu Ala Leu Phe Leu His Arg Ala 
225                 230                 235                 240 


Phe His Leu Ala Leu Leu Thr Ala His Leu Thr Leu Leu Leu Leu Phe 
                245                 250                 255     


Ala Leu Cys Arg Trp His Arg Thr Gly Glu Ser Ile Leu Ser Leu Leu 
            260                 265                 270         


Arg Asp Pro Ser Lys Arg Lys Val Pro Pro Gln Pro Leu Thr Pro Asn 
        275                 280                 285             


Gln Ile Val Ser Thr Leu Phe Thr Ser Asn Phe Ile Gly Ile Cys Phe 
    290                 295                 300                 


Ser Arg Ser Leu His Tyr Gln Phe Tyr Val Trp Tyr Phe His Thr Leu 
305                 310                 315                 320 


Pro Tyr Leu Leu Trp Ala Met Pro Ala Arg Trp Leu Thr His Leu Leu 
                325                 330                 335     


Arg Leu Leu Val Leu Gly Leu Ile Glu Leu Ser Trp Asn Thr Tyr Pro 
            340                 345                 350         


Ser Thr Ser Cys Ser Ser Ala Ala Leu His Ile Cys His Ala Val Ile 
        355                 360                 365             


Leu Leu Gln Leu Trp Leu Gly Pro Gln Pro Phe Pro Lys Ser Thr Gln 
    370                 375                 380                 


His Ser Lys Lys Ala His 
385                 390 


<210>  454
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG8__Homo_sapiens__NP_001007028

<400>  454

Met Ala Ala Leu Thr Ile Ala Thr Gly Thr Gly Asn Trp Phe Ser Ala 
1               5                   10                  15      


Leu Ala Leu Gly Val Thr Leu Leu Lys Cys Leu Leu Ile Pro Thr Tyr 
            20                  25                  30          


His Ser Thr Asp Phe Glu Val His Arg Asn Trp Leu Ala Ile Thr His 
        35                  40                  45              


Ser Leu Pro Ile Ser Gln Trp Tyr Tyr Glu Ala Thr Ser Glu Trp Thr 
    50                  55                  60                  


Leu Asp Tyr Pro Pro Phe Phe Ala Trp Phe Glu Tyr Ile Leu Ser His 
65                  70                  75                  80  


Val Ala Lys Tyr Phe Asp Gln Glu Met Leu Asn Val His Asn Leu Asn 
                85                  90                  95      


Tyr Ser Ser Ser Arg Thr Leu Leu Phe Gln Arg Phe Ser Val Ile Phe 
            100                 105                 110         


Met Asp Val Leu Phe Val Tyr Ala Val Arg Glu Cys Cys Lys Cys Ile 
        115                 120                 125             


Asp Gly Lys Lys Val Gly Lys Glu Leu Thr Glu Lys Pro Lys Phe Ile 
    130                 135                 140                 


Leu Ser Val Leu Leu Leu Trp Asn Phe Gly Leu Leu Ile Val Asp His 
145                 150                 155                 160 


Ile His Phe Gln Tyr Asn Gly Phe Leu Phe Gly Leu Met Leu Leu Ser 
                165                 170                 175     


Ile Ala Arg Leu Phe Gln Lys Arg His Met Glu Gly Ala Phe Leu Phe 
            180                 185                 190         


Ala Val Leu Leu His Phe Lys His Ile Tyr Leu Tyr Val Ala Pro Ala 
        195                 200                 205             


Tyr Gly Val Tyr Leu Leu Arg Ser Tyr Cys Phe Thr Ala Asn Lys Pro 
    210                 215                 220                 


Asp Gly Ser Ile Arg Trp Lys Ser Phe Ser Phe Val Arg Val Ile Ser 
225                 230                 235                 240 


Leu Gly Leu Val Val Phe Leu Val Ser Ala Leu Ser Leu Gly Pro Phe 
                245                 250                 255     


Leu Ala Leu Asn Gln Leu Pro Gln Val Phe Ser Arg Leu Phe Pro Phe 
            260                 265                 270         


Lys Arg Gly Leu Cys His Ala Tyr Trp Ala Pro Asn Phe Trp Ala Leu 
        275                 280                 285             


Tyr Asn Ala Leu Asp Lys Val Leu Ser Val Ile Gly Leu Lys Leu Lys 
    290                 295                 300                 


Phe Leu Asp Pro Asn Asn Ile Pro Lys Ala Ser Met Thr Ser Gly Leu 
305                 310                 315                 320 


Val Gln Gln Phe Gln His Thr Val Leu Pro Ser Val Thr Pro Leu Ala 
                325                 330                 335     


Thr Leu Ile Cys Thr Leu Ile Ala Ile Leu Pro Ser Ile Phe Cys Leu 
            340                 345                 350         


Trp Phe Lys Pro Gln Gly Pro Arg Gly Phe Leu Arg Cys Leu Thr Leu 
        355                 360                 365             


Cys Ala Leu Ser Ser Phe Met Phe Gly Trp His Val His Glu Lys Ala 
    370                 375                 380                 


Ile Leu Leu Ala Ile Leu Pro Met Ser Leu Leu Ser Val Gly Lys Ala 
385                 390                 395                 400 


Gly Asp Ala Ser Ile Phe Leu Ile Leu Thr Thr Thr Gly His Tyr Ser 
                405                 410                 415     


Leu Phe Pro Leu Leu Phe Thr Ala Pro Glu Leu Pro Ile Lys Ile Leu 
            420                 425                 430         


Leu Met Leu Leu Phe Thr Ile Tyr Ser Ile Ser Ser Leu Lys Thr Leu 
        435                 440                 445             


Phe Arg Arg Ser Phe Thr Leu Val Ala Gln Ala Gly Val Gln Trp His 
    450                 455                 460                 


Asp Leu Ser 
465         


<210>  455
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALG9__Homo_sapiens__NP_001071158

<400>  455

Met Ala Ser Arg Gly Ala Arg Gln Arg Leu Lys Gly Ser Gly Ala Ser 
1               5                   10                  15      


Ser Gly Asp Thr Ala Pro Ala Ala Asp Lys Leu Arg Glu Leu Leu Gly 
            20                  25                  30          


Ser Arg Glu Ala Gly Gly Ala Glu His Arg Thr Glu Leu Ser Gly Asn 
        35                  40                  45              


Lys Ala Gly Gln Val Trp Ala Pro Glu Gly Ser Thr Ala Phe Lys Cys 
    50                  55                  60                  


Leu Leu Ser Ala Arg Leu Cys Ala Ala Leu Leu Ser Asn Ile Ser Asp 
65                  70                  75                  80  


Cys Asp Glu Thr Phe Asn Tyr Trp Glu Pro Thr His Tyr Leu Ile Tyr 
                85                  90                  95      


Gly Glu Gly Phe Gln Thr Trp Glu Tyr Ser Pro Ala Tyr Ala Ile Arg 
            100                 105                 110         


Ser Tyr Ala Tyr Leu Leu Leu His Ala Trp Pro Ala Ala Phe His Ala 
        115                 120                 125             


Arg Ile Leu Gln Thr Asn Lys Ile Leu Val Phe Tyr Phe Leu Arg Cys 
    130                 135                 140                 


Leu Leu Ala Phe Val Ser Cys Ile Cys Glu Leu Tyr Phe Tyr Lys Ala 
145                 150                 155                 160 


Val Cys Lys Lys Phe Gly Leu His Val Ser Arg Met Met Leu Ala Phe 
                165                 170                 175     


Leu Val Leu Ser Thr Gly Met Phe Cys Ser Ser Ser Ala Phe Leu Pro 
            180                 185                 190         


Ser Ser Phe Cys Met Tyr Thr Thr Leu Ile Ala Met Thr Gly Trp Tyr 
        195                 200                 205             


Met Asp Lys Thr Ser Ile Ala Val Leu Gly Val Ala Ala Gly Ala Ile 
    210                 215                 220                 


Leu Gly Trp Pro Phe Ser Ala Ala Leu Gly Leu Pro Ile Ala Phe Asp 
225                 230                 235                 240 


Leu Leu Val Met Lys His Arg Trp Lys Ser Phe Phe His Trp Ser Leu 
                245                 250                 255     


Met Ala Leu Ile Leu Phe Leu Val Pro Val Val Val Ile Asp Ser Tyr 
            260                 265                 270         


Tyr Tyr Gly Lys Leu Val Ile Ala Pro Leu Asn Ile Val Leu Tyr Asn 
        275                 280                 285             


Val Phe Thr Pro His Gly Pro Asp Leu Tyr Gly Thr Glu Pro Trp Tyr 
    290                 295                 300                 


Phe Tyr Leu Ile Asn Gly Phe Leu Asn Phe Asn Val Ala Phe Ala Leu 
305                 310                 315                 320 


Ala Leu Leu Val Leu Pro Leu Thr Ser Leu Met Glu Tyr Leu Leu Gln 
                325                 330                 335     


Arg Phe His Val Gln Asn Leu Gly His Pro Tyr Trp Leu Thr Leu Ala 
            340                 345                 350         


Pro Met Tyr Ile Trp Phe Ile Ile Phe Phe Ile Gln Pro His Lys Glu 
        355                 360                 365             


Glu Arg Phe Leu Phe Pro Val Tyr Pro Leu Ile Cys Leu Cys Gly Ala 
    370                 375                 380                 


Val Ala Leu Ser Ala Leu Gln Lys Cys Tyr His Phe Val Phe Gln Arg 
385                 390                 395                 400 


Tyr Arg Leu Glu His Tyr Thr Val Thr Ser Asn Trp Leu Ala Leu Gly 
                405                 410                 415     


Thr Val Phe Leu Phe Gly Leu Leu Ser Phe Ser Arg Ser Val Ala Leu 
            420                 425                 430         


Phe Arg Gly Tyr His Gly Pro Leu Asp Leu Tyr Pro Glu Phe Tyr Arg 
        435                 440                 445             


Ile Ala Thr Asp Pro Thr Ile His Thr Val Pro Glu Gly Arg Pro Val 
    450                 455                 460                 


Asn Val Cys Val Gly Lys Glu Trp Tyr Arg Phe Pro Ser Ser Phe Leu 
465                 470                 475                 480 


Leu Pro Asp Asn Trp Gln Leu Gln Phe Ile Pro Ser Glu Phe Arg Gly 
                485                 490                 495     


Gln Leu Pro Lys Pro Phe Ala Glu Gly Pro Leu Ala Thr Arg Ile Val 
            500                 505                 510         


Pro Thr Asp Met Asn Asp Gln Asn Leu Glu Glu Pro Ser Arg Tyr Ile 
        515                 520                 525             


Asp Ile Ser Lys Cys His Tyr Leu Val Asp Leu Asp Thr Met Arg Glu 
    530                 535                 540                 


Thr Pro Arg Glu Pro Lys Tyr Ser Ser Asn Lys Glu Glu Trp Ile Ser 
545                 550                 555                 560 


Leu Ala Tyr Arg Pro Phe Leu Asp Ala Ser Arg Ser Ser Lys Leu Leu 
                565                 570                 575     


Arg Ala Phe Tyr Val Pro Phe Leu Ser Asp Gln Tyr Thr Val Tyr Val 
            580                 585                 590         


Asn Tyr Thr Ile Leu Lys Pro Arg Lys Ala Lys Gln Ile Arg Lys Lys 
        595                 600                 605             


Ser Gly Gly 
    610     


<210>  456
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALKBH1__Homo_sapiens__NP_006011

<400>  456

Met Gly Lys Met Ala Ala Ala Val Gly Ser Val Ala Thr Leu Ala Thr 
1               5                   10                  15      


Glu Pro Gly Glu Asp Ala Phe Arg Lys Leu Phe Arg Phe Tyr Arg Gln 
            20                  25                  30          


Ser Arg Pro Gly Thr Ala Asp Leu Glu Gly Val Ile Asp Phe Ser Ala 
        35                  40                  45              


Ala His Ala Ala Arg Gly Lys Gly Pro Gly Ala Gln Lys Val Ile Lys 
    50                  55                  60                  


Ser Gln Leu Asn Val Ser Ser Val Ser Glu Gln Asn Ala Tyr Arg Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Ser Lys Trp Gln Ala Tyr Gly Leu Lys Gly Tyr 
                85                  90                  95      


Pro Gly Phe Ile Phe Ile Pro Asn Pro Phe Leu Pro Gly Tyr Gln Trp 
            100                 105                 110         


His Trp Val Lys Gln Cys Leu Lys Leu Tyr Ser Gln Lys Pro Asn Val 
        115                 120                 125             


Cys Asn Leu Asp Lys His Met Ser Lys Glu Glu Thr Gln Asp Leu Trp 
    130                 135                 140                 


Glu Gln Ser Lys Glu Phe Leu Arg Tyr Lys Glu Ala Thr Lys Arg Arg 
145                 150                 155                 160 


Pro Arg Ser Leu Leu Glu Lys Leu Arg Trp Val Thr Val Gly Tyr His 
                165                 170                 175     


Tyr Asn Trp Asp Ser Lys Lys Tyr Ser Ala Asp His Tyr Thr Pro Phe 
            180                 185                 190         


Pro Ser Asp Leu Gly Phe Leu Ser Glu Gln Val Ala Ala Ala Cys Gly 
        195                 200                 205             


Phe Glu Asp Phe Arg Ala Glu Ala Gly Ile Leu Asn Tyr Tyr Arg Leu 
    210                 215                 220                 


Asp Ser Thr Leu Gly Ile His Val Asp Arg Ser Glu Leu Asp His Ser 
225                 230                 235                 240 


Lys Pro Leu Leu Ser Phe Ser Phe Gly Gln Ser Ala Ile Phe Leu Leu 
                245                 250                 255     


Gly Gly Leu Gln Arg Asp Glu Ala Pro Thr Ala Met Phe Met His Ser 
            260                 265                 270         


Gly Asp Ile Met Ile Met Ser Gly Phe Ser Arg Leu Leu Asn His Ala 
        275                 280                 285             


Val Pro Arg Val Leu Pro Asn Pro Glu Gly Glu Gly Leu Pro His Cys 
    290                 295                 300                 


Leu Glu Ala Pro Leu Pro Ala Val Leu Pro Arg Asp Ser Met Val Glu 
305                 310                 315                 320 


Pro Cys Ser Met Glu Asp Trp Gln Val Cys Ala Ser Tyr Leu Lys Thr 
                325                 330                 335     


Ala Arg Val Asn Met Thr Val Arg Gln Val Leu Ala Thr Asp Gln Asn 
            340                 345                 350         


Phe Pro Leu Glu Pro Ile Glu Asp Glu Lys Arg Asp Ile Ser Thr Glu 
        355                 360                 365             


Gly Phe Cys His Leu Asp Asp Gln Asn Ser Glu Val Lys Arg Ala Arg 
    370                 375                 380                 


Ile Asn Pro Asp Ser 
385                 


<210>  457
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALKBH2__Homo_sapiens__NP_001001655

<400>  457

Met Asp Arg Phe Leu Val Lys Gly Ala Gln Gly Gly Leu Leu Arg Lys 
1               5                   10                  15      


Gln Glu Glu Gln Glu Pro Thr Gly Glu Glu Pro Ala Val Leu Gly Gly 
            20                  25                  30          


Asp Lys Glu Ser Thr Arg Lys Arg Pro Arg Arg Glu Ala Pro Gly Asn 
        35                  40                  45              


Gly Gly His Ser Ala Gly Pro Ser Trp Arg His Ile Arg Ala Glu Gly 
    50                  55                  60                  


Leu Asp Cys Ser Tyr Thr Val Leu Phe Gly Lys Ala Glu Ala Asp Glu 
65                  70                  75                  80  


Ile Phe Gln Glu Leu Glu Lys Glu Val Glu Tyr Phe Thr Gly Ala Leu 
                85                  90                  95      


Ala Arg Val Gln Val Phe Gly Lys Trp His Ser Val Pro Arg Lys Gln 
            100                 105                 110         


Ala Thr Tyr Gly Asp Ala Gly Leu Thr Tyr Thr Phe Ser Gly Leu Thr 
        115                 120                 125             


Leu Ser Pro Lys Pro Trp Ile Pro Val Leu Glu Arg Ile Arg Asp His 
    130                 135                 140                 


Val Ser Gly Val Thr Gly Gln Thr Phe Asn Phe Val Leu Ile Asn Arg 
145                 150                 155                 160 


Tyr Lys Asp Gly Cys Asp His Ile Gly Glu His Arg Asp Asp Glu Arg 
                165                 170                 175     


Glu Leu Ala Pro Gly Ser Pro Ile Ala Ser Val Ser Phe Gly Ala Cys 
            180                 185                 190         


Arg Asp Phe Val Phe Arg His Lys Asp Ser Arg Gly Lys Ser Pro Ser 
        195                 200                 205             


Arg Arg Val Ala Val Val Arg Leu Pro Leu Ala His Gly Ser Leu Leu 
    210                 215                 220                 


Met Met Asn His Pro Thr Asn Thr His Trp Tyr His Ser Leu Pro Val 
225                 230                 235                 240 


Arg Lys Lys Val Leu Ala Pro Arg Val Asn Leu Thr Phe Arg Lys Ile 
                245                 250                 255     


Leu Leu Thr Lys Lys 
            260     


<210>  458
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALKBH3__Homo_sapiens__NP_631917

<400>  458

Met Glu Glu Lys Arg Arg Arg Ala Arg Val Gln Gly Ala Trp Ala Ala 
1               5                   10                  15      


Pro Val Lys Ser Gln Ala Ile Ala Gln Pro Ala Thr Thr Ala Lys Ser 
            20                  25                  30          


His Leu His Gln Lys Pro Gly Gln Thr Trp Lys Asn Lys Glu His His 
        35                  40                  45              


Leu Ser Asp Arg Glu Phe Val Phe Lys Glu Pro Gln Gln Val Val Arg 
    50                  55                  60                  


Arg Ala Pro Glu Pro Arg Val Ile Asp Arg Glu Gly Val Tyr Glu Ile 
65                  70                  75                  80  


Ser Leu Ser Pro Thr Gly Val Ser Arg Val Cys Leu Tyr Pro Gly Phe 
                85                  90                  95      


Val Asp Val Lys Glu Ala Asp Trp Ile Leu Glu Gln Leu Cys Gln Asp 
            100                 105                 110         


Val Pro Trp Lys Gln Arg Thr Gly Ile Arg Glu Asp Ile Thr Tyr Gln 
        115                 120                 125             


Gln Pro Arg Leu Thr Ala Trp Tyr Gly Glu Leu Pro Tyr Thr Tyr Ser 
    130                 135                 140                 


Arg Ile Thr Met Glu Pro Asn Pro His Trp His Pro Val Leu Arg Thr 
145                 150                 155                 160 


Leu Lys Asn Arg Ile Glu Glu Asn Thr Gly His Thr Phe Asn Ser Leu 
                165                 170                 175     


Leu Cys Asn Leu Tyr Arg Asn Glu Lys Asp Ser Val Asp Trp His Ser 
            180                 185                 190         


Asp Asp Glu Pro Ser Leu Gly Arg Cys Pro Ile Ile Ala Ser Leu Ser 
        195                 200                 205             


Phe Gly Ala Thr Arg Thr Phe Glu Met Arg Lys Lys Pro Pro Pro Glu 
    210                 215                 220                 


Glu Asn Gly Asp Tyr Thr Tyr Val Glu Arg Val Lys Ile Pro Leu Asp 
225                 230                 235                 240 


His Gly Thr Leu Leu Ile Met Glu Gly Ala Thr Gln Ala Asp Trp Gln 
                245                 250                 255     


His Arg Val Pro Lys Glu Tyr His Ser Arg Glu Pro Arg Val Asn Leu 
            260                 265                 270         


Thr Phe Arg Thr Val Tyr Pro Asp Pro Arg Gly Ala Pro Trp 
        275                 280                 285     


<210>  459
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALKBH7__Homo_sapiens__NP_115682

<400>  459

Met Ala Gly Thr Gly Leu Leu Ala Leu Arg Thr Leu Pro Gly Pro Ser 
1               5                   10                  15      


Trp Val Arg Gly Ser Gly Pro Ser Val Leu Ser Arg Leu Gln Asp Ala 
            20                  25                  30          


Ala Val Val Arg Pro Gly Phe Leu Ser Thr Ala Glu Glu Glu Thr Leu 
        35                  40                  45              


Ser Arg Glu Leu Glu Pro Glu Leu Arg Arg Arg Arg Tyr Glu Tyr Asp 
    50                  55                  60                  


His Trp Asp Ala Ala Ile His Gly Phe Arg Glu Thr Glu Lys Ser Arg 
65                  70                  75                  80  


Trp Ser Glu Ala Ser Arg Ala Ile Leu Gln Arg Val Gln Ala Ala Ala 
                85                  90                  95      


Phe Gly Pro Gly Gln Thr Leu Leu Ser Ser Val His Val Leu Asp Leu 
            100                 105                 110         


Glu Ala Arg Gly Tyr Ile Lys Pro His Val Asp Ser Ile Lys Phe Cys 
        115                 120                 125             


Gly Ala Thr Ile Ala Gly Leu Ser Leu Leu Ser Pro Ser Val Met Arg 
    130                 135                 140                 


Leu Val His Thr Gln Glu Pro Gly Glu Trp Leu Glu Leu Leu Leu Glu 
145                 150                 155                 160 


Pro Gly Ser Leu Tyr Ile Leu Arg Gly Ser Ala Arg Tyr Asp Phe Ser 
                165                 170                 175     


His Glu Ile Leu Arg Asp Glu Glu Ser Phe Phe Gly Glu Arg Arg Ile 
            180                 185                 190         


Pro Arg Gly Arg Arg Ile Ser Val Ile Cys Arg Ser Leu Pro Glu Gly 
        195                 200                 205             


Met Gly Pro Gly Glu Ser Gly Gln Pro Pro Pro Ala Cys 
    210                 215                 220     


<210>  460
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALKBH8__Homo_sapiens__NP_001287939

<400>  460

Met Phe Ala Met Asp Ser Asn His Gln Ser Asn Tyr Lys Leu Ser Lys 
1               5                   10                  15      


Thr Glu Lys Lys Phe Leu Arg Lys Gln Ile Lys Ala Lys His Thr Leu 
            20                  25                  30          


Leu Arg His Glu Gly Ile Glu Thr Val Ser Tyr Ala Thr Gln Ser Leu 
        35                  40                  45              


Val Val Ala Asn Gly Gly Leu Gly Asn Gly Val Ser Arg Asn Gln Leu 
    50                  55                  60                  


Leu Pro Val Leu Glu Lys Cys Gly Leu Val Asp Ala Leu Leu Met Pro 
65                  70                  75                  80  


Pro Asn Lys Pro Tyr Ser Phe Ala Arg Tyr Arg Thr Thr Glu Glu Ser 
                85                  90                  95      


Lys Arg Ala Tyr Val Thr Leu Asn Gly Lys Glu Val Val Asp Asp Leu 
            100                 105                 110         


Gly Gln Lys Ile Thr Leu Tyr Leu Asn Phe Val Glu Lys Val Gln Trp 
        115                 120                 125             


Lys Glu Leu Arg Pro Gln Ala Leu Pro Pro Gly Leu Met Val Val Glu 
    130                 135                 140                 


Glu Ile Ile Ser Ser Glu Glu Glu Lys Met Leu Leu Glu Ser Val Asp 
145                 150                 155                 160 


Trp Thr Glu Asp Thr Asp Asn Gln Asn Ser Gln Lys Ser Leu Lys His 
                165                 170                 175     


Arg Arg Val Lys His Phe Gly Tyr Glu Phe His Tyr Glu Asn Asn Asn 
            180                 185                 190         


Val Asp Lys Asp Lys Pro Leu Ser Gly Gly Leu Pro Asp Ile Cys Glu 
        195                 200                 205             


Ser Phe Leu Glu Lys Trp Leu Arg Lys Gly Tyr Ile Lys His Lys Pro 
    210                 215                 220                 


Asp Gln Met Thr Ile Asn Gln Tyr Glu Pro Gly Gln Gly Ile Pro Ala 
225                 230                 235                 240 


His Ile Asp Thr His Ser Ala Phe Glu Asp Glu Ile Val Ser Leu Ser 
                245                 250                 255     


Leu Gly Ser Glu Ile Val Met Asp Phe Lys His Pro Asp Gly Ile Ala 
            260                 265                 270         


Val Pro Val Met Leu Pro Arg Arg Ser Leu Leu Val Met Thr Gly Glu 
        275                 280                 285             


Ser Arg Tyr Leu Trp Thr His Gly Ile Thr Cys Arg Lys Phe Asp Thr 
    290                 295                 300                 


Val Gln Ala Ser Glu Ser Leu Lys Ser Gly Ile Ile Thr Ser Asp Val 
305                 310                 315                 320 


Gly Asp Leu Thr Leu Ser Lys Arg Gly Leu Arg Thr Ser Phe Thr Phe 
                325                 330                 335     


Arg Lys Val Arg Gln Thr Pro Cys Asn Cys Ser Tyr Pro Leu Val Cys 
            340                 345                 350         


Asp Ser Gln Arg Lys Glu Thr Pro Pro Ser Phe Pro Glu Ser Asp Lys 
        355                 360                 365             


Glu Ala Ser Arg Leu Glu Gln Glu Tyr Val His Gln Val Tyr Glu Glu 
    370                 375                 380                 


Ile Ala Gly His Phe Ser Ser Thr Arg His Thr Pro Trp Pro His Ile 
385                 390                 395                 400 


Val Glu Phe Leu Lys Ala Leu Pro Ser Gly Ser Ile Val Ala Asp Ile 
                405                 410                 415     


Gly Cys Gly Asn Gly Lys Tyr Leu Gly Ile Asn Lys Glu Leu Tyr Met 
            420                 425                 430         


Ile Gly Cys Asp Arg Ser Gln Asn Leu Val Asp Ile Cys Arg Glu Arg 
        435                 440                 445             


Gln Phe Gln Ala Phe Val Cys Asp Ala Leu Ala Val Pro Val Arg Ser 
    450                 455                 460                 


Gly Ser Cys Asp Ala Cys Ile Ser Ile Ala Val Ile His His Phe Ala 
465                 470                 475                 480 


Thr Ala Glu Arg Arg Val Ala Ala Leu Gln Glu Ile Val Arg Leu Leu 
                485                 490                 495     


Arg Pro Gly Gly Lys Ala Leu Ile Tyr Val Trp Ala Met Glu Gln Glu 
            500                 505                 510         


Tyr Asn Lys Gln Lys Ser Lys Tyr Leu Arg Gly Asn Arg Asn Ser Gln 
        515                 520                 525             


Gly Lys Lys Glu Glu Met Asn Ser Asp Thr Ser Val Gln Arg Ser Leu 
    530                 535                 540                 


Val Glu Gln Met Arg Asp Met Gly Ser Arg Asp Ser Ala Ser Ser Val 
545                 550                 555                 560 


Pro Arg Ile Asn Asp Ser Gln Glu Gly Gly Cys Asn Ser Arg Gln Val 
                565                 570                 575     


Ser Asn Ser Lys Leu Pro Val His Val Asn Arg Thr Ser Phe Tyr Ser 
            580                 585                 590         


Gln Asp Val Leu Val Pro Trp His Leu Lys Gly Asn Pro Asp Lys Gly 
        595                 600                 605             


Lys Pro Val Glu Pro Phe Gly Pro Ile Gly Ser Gln Asp Pro Ser Pro 
    610                 615                 620                 


Val Phe His Arg Tyr Tyr His Val Phe Arg Glu Gly Glu Leu Glu Gly 
625                 630                 635                 640 


Ala Cys Arg Thr Val Ser Asp Val Arg Ile Leu Gln Ser Tyr Tyr Asp 
                645                 650                 655     


Gln Gly Asn Trp Cys Val Ile Leu Gln Lys Ala 
            660                 665         


<210>  461
<211>  1620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALK__Homo_sapiens__NP_004295

<400>  461

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  462
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALLC__Homo_sapiens__NP_060906

<400>  462

Met Asp Met Ala Ser Glu Ser Val Gly Gly Lys Ile Leu Phe Ala Thr 
1               5                   10                  15      


Asp Asp Phe Phe Ala Pro Ala Glu Asn Leu Ile Lys Ser Asp Ser Pro 
            20                  25                  30          


Cys Phe Lys Glu His Glu Tyr Thr Glu Phe Gly Lys Trp Met Asp Gly 
        35                  40                  45              


Trp Glu Thr Arg Arg Lys Arg Ile Pro Gly His Asp Trp Cys Val Leu 
    50                  55                  60                  


Arg Leu Gly Ile Gln Gly Val Ile Arg Gly Phe Asp Val Asp Val Ser 
65                  70                  75                  80  


Tyr Phe Thr Gly Asp Tyr Ala Pro Arg Val Ser Ile Gln Ala Ala Asn 
                85                  90                  95      


Leu Glu Glu Asp Lys Leu Pro Glu Ile Pro Glu Arg Gly Thr Arg Thr 
            100                 105                 110         


Gly Ala Ala Ala Thr Pro Glu Glu Phe Glu Ala Ile Ala Glu Leu Lys 
        115                 120                 125             


Ser Asp Asp Trp Ser Tyr Leu Val Pro Met Thr Glu Leu Lys Pro Gly 
    130                 135                 140                 


Asn Pro Ala Ser Gly His Asn Tyr Phe Leu Val Asn Ser Gln Gln Arg 
145                 150                 155                 160 


Trp Thr His Ile Arg Leu Asn Ile Phe Pro Asp Gly Gly Ile Ala Arg 
                165                 170                 175     


Leu Arg Val Phe Gly Thr Gly Gln Lys Asp Trp Thr Ala Thr Asp Pro 
            180                 185                 190         


Lys Glu Pro Ala Asp Leu Val Ala Ile Ala Phe Gly Gly Val Cys Val 
        195                 200                 205             


Gly Phe Ser Asn Ala Lys Phe Gly His Pro Asn Asn Ile Ile Gly Val 
    210                 215                 220                 


Gly Gly Ala Lys Ser Met Ala Asp Gly Trp Glu Thr Ala Arg Arg Leu 
225                 230                 235                 240 


Asp Arg Pro Pro Ile Leu Glu Asn Asp Glu Asn Gly Ile Leu Leu Val 
                245                 250                 255     


Pro Gly Cys Glu Trp Ala Val Phe Arg Leu Ala His Pro Gly Val Ile 
            260                 265                 270         


Thr Arg Ile Glu Ile Asp Thr Lys Tyr Phe Glu Gly Asn Ala Pro Asp 
        275                 280                 285             


Ser Cys Lys Val Asp Gly Cys Ile Leu Thr Thr Gln Glu Glu Glu Ala 
    290                 295                 300                 


Val Ile Arg Gln Lys Trp Ile Leu Pro Ala His Lys Trp Lys Pro Leu 
305                 310                 315                 320 


Leu Pro Val Thr Lys Leu Ser Pro Asn Gln Ser His Leu Phe Asp Ser 
                325                 330                 335     


Leu Thr Leu Glu Leu Gln Asp Val Ile Thr His Ala Arg Leu Thr Ile 
            340                 345                 350         


Val Pro Asp Gly Gly Val Ser Arg Leu Arg Leu Arg Gly Phe Pro Ser 
        355                 360                 365             


Ser Ile Cys Leu Leu Arg Pro Arg Glu Lys Pro Met Leu Lys Phe Ser 
    370                 375                 380                 


Val Ser Phe Lys Ala Asn Pro 
385                 390     


<210>  463
<211>  4169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALMS1__Homo_sapiens__NP_055935

<400>  463

Met Glu Pro Glu Asp Leu Pro Trp Pro Gly Glu Leu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Asn Val Asp Asp Val Val Val Val Glu Glu Val Glu 
        35                  40                  45              


Glu Glu Ala Gly Arg Glu Leu Asp Ser Asp Ser His Tyr Gly Pro Gln 
    50                  55                  60                  


His Leu Glu Ser Ile Asp Asp Glu Glu Asp Glu Glu Ala Lys Ala Trp 
65                  70                  75                  80  


Leu Gln Ala His Pro Gly Arg Ile Leu Pro Pro Leu Ser Pro Pro Gln 
                85                  90                  95      


His Arg Tyr Ser Glu Gly Glu Arg Thr Ser Leu Glu Lys Ile Val Pro 
            100                 105                 110         


Leu Thr Cys His Val Trp Gln Gln Ile Val Tyr Gln Gly Asn Ser Arg 
        115                 120                 125             


Thr Gln Ile Ser Asp Thr Asn Val Val Cys Leu Glu Thr Thr Ala Gln 
    130                 135                 140                 


Arg Gly Ser Gly Asp Asp Gln Lys Thr Glu Ser Trp His Cys Leu Pro 
145                 150                 155                 160 


Gln Glu Met Asp Ser Ser Gln Thr Leu Asp Thr Ser Gln Thr Arg Phe 
                165                 170                 175     


Asn Val Arg Thr Glu Asp Thr Glu Val Thr Asp Phe Pro Ser Leu Glu 
            180                 185                 190         


Glu Gly Ile Leu Thr Gln Ser Glu Asn Gln Val Lys Glu Pro Asn Arg 
        195                 200                 205             


Asp Leu Phe Cys Ser Pro Leu Leu Val Ile Gln Asp Ser Phe Ala Ser 
    210                 215                 220                 


Pro Asp Leu Pro Leu Leu Thr Cys Leu Thr Gln Asp Gln Glu Phe Ala 
225                 230                 235                 240 


Pro Asp Ser Leu Phe His Gln Ser Glu Leu Ser Phe Ala Pro Leu Arg 
                245                 250                 255     


Gly Ile Pro Asp Lys Ser Glu Asp Thr Glu Trp Ser Ser Arg Pro Ser 
            260                 265                 270         


Glu Val Ser Glu Ala Leu Phe Gln Ala Thr Ala Glu Val Ala Ser Asp 
        275                 280                 285             


Leu Ala Ser Ser Arg Phe Ser Val Ser Gln His Pro Leu Ile Gly Ser 
    290                 295                 300                 


Thr Ala Val Gly Ser Gln Cys Pro Phe Leu Pro Ser Glu Gln Gly Asn 
305                 310                 315                 320 


Asn Glu Glu Thr Ile Ser Ser Val Asp Glu Leu Lys Ile Pro Lys Asp 
                325                 330                 335     


Cys Asp Arg Tyr Asp Asp Leu Cys Ser Tyr Met Ser Trp Lys Thr Arg 
            340                 345                 350         


Lys Asp Thr Gln Trp Pro Glu Asn Asn Leu Ala Asp Lys Asp Gln Val 
        355                 360                 365             


Ser Val Ala Thr Ser Phe Asp Ile Thr Asp Glu Asn Ile Ala Thr Lys 
    370                 375                 380                 


Arg Ser Asp His Phe Asp Ala Ala Arg Ser Tyr Gly Gln Tyr Trp Thr 
385                 390                 395                 400 


Gln Glu Asp Ser Ser Lys Gln Ala Glu Thr Tyr Leu Thr Lys Gly Leu 
                405                 410                 415     


Gln Gly Lys Val Glu Ser Asp Val Ile Thr Leu Asp Gly Leu Asn Glu 
            420                 425                 430         


Asn Ala Val Val Cys Ser Glu Arg Val Ala Glu Leu Gln Arg Lys Pro 
        435                 440                 445             


Thr Arg Glu Ser Glu Tyr His Ser Ser Asp Leu Arg Met Leu Arg Met 
    450                 455                 460                 


Ser Pro Asp Thr Val Pro Lys Ala Pro Lys His Leu Lys Ala Gly Asp 
465                 470                 475                 480 


Thr Ser Lys Gly Gly Ile Ala Lys Val Thr Gln Ser Asn Leu Lys Ser 
                485                 490                 495     


Gly Ile Thr Thr Thr Pro Val Asp Ser Asp Ile Gly Ser His Leu Ser 
            500                 505                 510         


Leu Ser Leu Glu Asp Leu Ser Gln Leu Ala Val Ser Ser Pro Leu Glu 
        515                 520                 525             


Thr Thr Thr Gly Gln His Thr Asp Thr Leu Asn Gln Lys Thr Leu Ala 
    530                 535                 540                 


Asp Thr His Leu Thr Glu Glu Thr Leu Lys Val Thr Ala Ile Pro Glu 
545                 550                 555                 560 


Pro Ala Asp Gln Lys Thr Ala Thr Pro Thr Val Leu Ser Ser Ser His 
                565                 570                 575     


Ser His Arg Gly Lys Pro Ser Ile Phe Tyr Gln Gln Gly Leu Pro Asp 
            580                 585                 590         


Ser His Leu Thr Glu Glu Ala Leu Lys Val Ser Ala Ala Pro Gly Leu 
        595                 600                 605             


Ala Asp Gln Thr Thr Gly Met Ser Thr Leu Thr Ser Thr Ser Tyr Ser 
    610                 615                 620                 


His Arg Glu Lys Pro Gly Thr Phe Tyr Gln Gln Glu Leu Pro Glu Ser 
625                 630                 635                 640 


Asn Leu Thr Glu Glu Pro Leu Glu Val Ser Ala Ala Pro Gly Pro Val 
                645                 650                 655     


Glu Gln Lys Thr Gly Ile Pro Thr Val Ser Ser Thr Ser His Ser His 
            660                 665                 670         


Val Glu Asp Leu Leu Phe Phe Tyr Arg Gln Thr Leu Pro Asp Gly His 
        675                 680                 685             


Leu Thr Asp Gln Ala Leu Lys Val Ser Ala Val Ser Gly Pro Ala Asp 
    690                 695                 700                 


Gln Lys Thr Gly Thr Ala Thr Val Leu Ser Thr Pro His Ser His Arg 
705                 710                 715                 720 


Glu Lys Pro Gly Ile Phe Tyr Gln Gln Glu Phe Ala Asp Ser His Gln 
                725                 730                 735     


Thr Glu Glu Thr Leu Thr Lys Val Ser Ala Thr Pro Gly Pro Ala Asp 
            740                 745                 750         


Gln Lys Thr Glu Ile Pro Ala Val Gln Ser Ser Ser Tyr Ser Gln Arg 
        755                 760                 765             


Glu Lys Pro Ser Ile Leu Tyr Pro Gln Asp Leu Ala Asp Ser His Leu 
    770                 775                 780                 


Pro Glu Glu Gly Leu Lys Val Ser Ala Val Ala Gly Pro Ala Asp Gln 
785                 790                 795                 800 


Lys Thr Gly Leu Pro Thr Val Pro Ser Ser Ala Tyr Ser His Arg Glu 
                805                 810                 815     


Lys Leu Leu Val Phe Tyr Gln Gln Ala Leu Leu Asp Ser His Leu Pro 
            820                 825                 830         


Glu Glu Ala Leu Lys Val Ser Ala Val Ser Gly Pro Ala Asp Gly Lys 
        835                 840                 845             


Thr Gly Thr Pro Ala Val Thr Ser Thr Ser Ser Ala Ser Ser Ser Leu 
    850                 855                 860                 


Gly Glu Lys Pro Ser Ala Phe Tyr Gln Gln Thr Leu Pro Asn Ser His 
865                 870                 875                 880 


Leu Thr Glu Glu Ala Leu Lys Val Ser Ile Val Pro Gly Pro Gly Asp 
                885                 890                 895     


Gln Lys Thr Gly Ile Pro Ser Ala Pro Ser Ser Phe Tyr Ser His Arg 
            900                 905                 910         


Glu Lys Pro Ile Ile Phe Ser Gln Gln Thr Leu Pro Asp Phe Leu Phe 
        915                 920                 925             


Pro Glu Glu Ala Leu Lys Val Ser Ala Val Ser Val Leu Ala Ala Gln 
    930                 935                 940                 


Lys Thr Gly Thr Pro Thr Val Ser Ser Asn Ser His Ser His Ser Glu 
945                 950                 955                 960 


Lys Ser Ser Val Phe Tyr Gln Gln Glu Leu Pro Asp Ser Asp Leu Pro 
                965                 970                 975     


Arg Glu Ser Leu Lys Met Ser Ala Ile Pro Gly Leu Thr Asp Gln Lys 
            980                 985                 990         


Thr Val Pro Thr Pro Thr Val Pro  Ser Gly Ser Phe Ser  His Arg Glu 
        995                 1000                 1005             


Lys Pro  Ser Ile Phe Tyr Gln  Gln Glu Trp Pro Asp  Ser Tyr Ala 
    1010                 1015                 1020             


Thr Glu  Lys Ala Leu Lys Val  Ser Thr Gly Pro Gly  Pro Ala Asp 
    1025                 1030                 1035             


Gln Lys  Thr Glu Ile Pro Ala  Val Gln Ser Ser Ser  Tyr Pro Gln 
    1040                 1045                 1050             


Arg Glu  Lys Pro Ser Val Leu  Tyr Pro Gln Val Leu  Ser Asp Ser 
    1055                 1060                 1065             


His Leu  Pro Glu Glu Ser Leu  Lys Val Ser Ala Phe  Pro Gly Pro 
    1070                 1075                 1080             


Ala Asp  Gln Met Thr Asp Thr  Pro Ala Val Pro Ser  Thr Phe Tyr 
    1085                 1090                 1095             


Ser Gln  Arg Glu Lys Pro Gly  Ile Phe Tyr Gln Gln  Thr Leu Pro 
    1100                 1105                 1110             


Glu Ser  His Leu Pro Lys Glu  Ala Leu Lys Ile Ser  Val Ala Pro 
    1115                 1120                 1125             


Gly Leu  Ala Asp Gln Lys Thr  Gly Thr Pro Thr Val  Thr Ser Thr 
    1130                 1135                 1140             


Ser Tyr  Ser Gln His Arg Glu  Lys Pro Ser Ile Phe  His Gln Gln 
    1145                 1150                 1155             


Ala Leu  Pro Gly Thr His Ile  Pro Glu Glu Ala Gln  Lys Val Ser 
    1160                 1165                 1170             


Ala Val  Thr Gly Pro Gly Asn  Gln Lys Thr Trp Ile  Pro Arg Val 
    1175                 1180                 1185             


Leu Ser  Thr Phe Tyr Ser Gln  Arg Glu Lys Pro Gly  Ile Phe Tyr 
    1190                 1195                 1200             


Gln Gln  Thr Leu Pro Gly Ser  His Ile Pro Glu Glu  Ala Gln Lys 
    1205                 1210                 1215             


Val Ser  Pro Val Leu Gly Pro  Ala Asp Gln Lys Thr  Gly Thr Pro 
    1220                 1225                 1230             


Thr Pro  Thr Ser Ala Ser Tyr  Ser His Thr Glu Lys  Pro Gly Ile 
    1235                 1240                 1245             


Phe Tyr  Gln Gln Val Leu Pro  Asp Asn His Pro Thr  Glu Glu Ala 
    1250                 1255                 1260             


Leu Lys  Ile Ser Val Ala Ser  Glu Pro Val Asp Gln  Thr Thr Gly 
    1265                 1270                 1275             


Thr Pro  Ala Val Thr Ser Thr  Ser Tyr Ser Gln Tyr  Arg Glu Lys 
    1280                 1285                 1290             


Pro Ser  Ile Phe Tyr Gln Gln  Ser Leu Pro Ser Ser  His Leu Thr 
    1295                 1300                 1305             


Glu Glu  Ala Lys Asn Val Ser  Ala Val Pro Gly Pro  Ala Asp Gln 
    1310                 1315                 1320             


Lys Thr  Val Ile Pro Ile Leu  Pro Ser Thr Phe Tyr  Ser His Thr 
    1325                 1330                 1335             


Glu Lys  Pro Gly Val Phe Tyr  Gln Gln Val Leu Pro  His Ser His 
    1340                 1345                 1350             


Pro Thr  Glu Glu Ala Leu Lys  Ile Ser Val Ala Ser  Glu Pro Val 
    1355                 1360                 1365             


Asp Gln  Thr Thr Gly Thr Pro  Thr Val Thr Ser Thr  Ser Tyr Ser 
    1370                 1375                 1380             


Gln His  Thr Glu Lys Pro Ser  Ile Phe Tyr Gln Gln  Ser Leu Pro 
    1385                 1390                 1395             


Gly Ser  His Leu Thr Glu Glu  Ala Lys Asn Val Ser  Ala Val Pro 
    1400                 1405                 1410             


Gly Pro  Gly Asp Arg Lys Thr  Gly Ile Pro Thr Leu  Pro Ser Thr 
    1415                 1420                 1425             


Phe Tyr  Ser His Thr Glu Lys  Pro Gly Ser Phe Tyr  Gln Gln Val 
    1430                 1435                 1440             


Leu Pro  His Ser His Leu Pro  Glu Glu Ala Leu Glu  Val Ser Val 
    1445                 1450                 1455             


Ala Pro  Gly Pro Val Asp Gln  Thr Ile Gly Thr Pro  Thr Val Thr 
    1460                 1465                 1470             


Ser Pro  Ser Ser Ser Phe Gly  Glu Lys Pro Ile Val  Ile Tyr Lys 
    1475                 1480                 1485             


Gln Ala  Phe Pro Glu Gly His  Leu Pro Glu Glu Ser  Leu Lys Val 
    1490                 1495                 1500             


Ser Val  Ala Pro Gly Pro Val  Gly Gln Thr Thr Gly  Ala Pro Thr 
    1505                 1510                 1515             


Ile Thr  Ser Pro Ser Tyr Ser  Gln His Arg Ala Lys  Ser Gly Ser 
    1520                 1525                 1530             


Phe Tyr  Gln Leu Ala Leu Leu  Gly Ser Gln Ile Pro  Glu Glu Ala 
    1535                 1540                 1545             


Leu Arg  Val Ser Ser Ala Pro  Gly Pro Ala Asp Gln  Thr Thr Gly 
    1550                 1555                 1560             


Ile Pro  Thr Ile Thr Ser Thr  Ser Tyr Ser Phe Gly  Glu Lys Pro 
    1565                 1570                 1575             


Ile Val  Asn Tyr Lys Gln Ala  Phe Pro Asp Gly His  Leu Pro Glu 
    1580                 1585                 1590             


Glu Ala  Leu Lys Val Ser Ile  Val Ser Gly Pro Thr  Glu Lys Lys 
    1595                 1600                 1605             


Thr Asp  Ile Pro Ala Gly Pro  Leu Gly Ser Ser Ala  Leu Gly Glu 
    1610                 1615                 1620             


Lys Pro  Ile Thr Phe Tyr Arg  Gln Ala Leu Leu Asp  Ser Pro Leu 
    1625                 1630                 1635             


Asn Lys  Glu Val Val Lys Val  Ser Ala Ala Pro Gly  Pro Ala Asp 
    1640                 1645                 1650             


Gln Lys  Thr Glu Thr Leu Pro  Val His Ser Thr Ser  Tyr Ser Asn 
    1655                 1660                 1665             


Arg Gly  Lys Pro Val Ile Phe  Tyr Gln Gln Thr Leu  Ser Asp Ser 
    1670                 1675                 1680             


His Leu  Pro Glu Glu Ala Leu  Lys Val Pro Pro Val  Pro Gly Pro 
    1685                 1690                 1695             


Asp Ala  Gln Lys Thr Glu Thr  Pro Ser Val Ser Ser  Ser Leu Tyr 
    1700                 1705                 1710             


Ser Tyr  Arg Glu Lys Pro Ile  Val Phe Tyr Gln Gln  Ala Leu Pro 
    1715                 1720                 1725             


Asp Ser  Glu Leu Thr Gln Glu  Ala Leu Lys Val Ser  Ala Val Pro 
    1730                 1735                 1740             


Gln Pro  Ala Asp Gln Lys Thr  Gly Leu Ser Thr Val  Thr Ser Ser 
    1745                 1750                 1755             


Phe Tyr  Ser His Thr Glu Lys  Pro Asn Ile Ser Tyr  Gln Gln Glu 
    1760                 1765                 1770             


Leu Pro  Asp Ser His Leu Thr  Glu Glu Ala Leu Lys  Val Ser Asn 
    1775                 1780                 1785             


Val Pro  Gly Pro Ala Asp Gln  Lys Thr Gly Val Ser  Thr Val Thr 
    1790                 1795                 1800             


Ser Thr  Ser Tyr Ser His Arg  Glu Lys Pro Ile Val  Ser Tyr Gln 
    1805                 1810                 1815             


Arg Glu  Leu Pro His Phe Thr  Glu Ala Gly Leu Lys  Ile Leu Arg 
    1820                 1825                 1830             


Val Pro  Gly Pro Ala Asp Gln  Lys Thr Gly Ile Asn  Ile Leu Pro 
    1835                 1840                 1845             


Ser Asn  Ser Tyr Pro Gln Arg  Glu His Ser Val Ile  Ser Tyr Glu 
    1850                 1855                 1860             


Gln Glu  Leu Pro Asp Leu Thr  Glu Val Thr Leu Lys  Ala Ile Gly 
    1865                 1870                 1875             


Val Pro  Gly Pro Ala Asp Gln  Lys Thr Gly Ile Gln  Ile Ala Ser 
    1880                 1885                 1890             


Ser Ser  Ser Tyr Ser Asn Arg  Glu Lys Ala Ser Ile  Phe His Gln 
    1895                 1900                 1905             


Gln Glu  Leu Pro Asp Val Thr  Glu Glu Ala Leu Asn  Val Phe Val 
    1910                 1915                 1920             


Val Pro  Gly Gln Gly Asp Arg  Lys Thr Glu Ile Pro  Thr Val Pro 
    1925                 1930                 1935             


Leu Ser  Tyr Tyr Ser Arg Arg  Glu Lys Pro Ser Val  Ile Ser Gln 
    1940                 1945                 1950             


Gln Glu  Leu Pro Asp Ser His  Leu Thr Glu Glu Ala  Leu Lys Val 
    1955                 1960                 1965             


Ser Pro  Val Ser Ile Pro Ala  Glu Gln Lys Thr Gly  Ile Pro Ile 
    1970                 1975                 1980             


Gly Leu  Ser Ser Ser Tyr Ser  His Ser His Lys Glu  Lys Leu Lys 
    1985                 1990                 1995             


Ile Ser  Thr Val His Ile Pro  Asp Asp Gln Lys Thr  Glu Phe Pro 
    2000                 2005                 2010             


Ala Ala  Thr Leu Ser Ser Tyr  Ser Gln Ile Glu Lys  Pro Lys Ile 
    2015                 2020                 2025             


Ser Thr  Val Ile Gly Pro Asn  Asp Gln Lys Thr Pro  Ser Gln Thr 
    2030                 2035                 2040             


Ala Phe  His Ser Ser Tyr Ser  Gln Thr Val Lys Pro  Asn Ile Leu 
    2045                 2050                 2055             


Phe Gln  Gln Gln Leu Pro Asp  Arg Asp Gln Ser Lys  Gly Ile Leu 
    2060                 2065                 2070             


Lys Ile  Ser Ala Val Pro Glu  Leu Thr Asp Val Asn  Thr Gly Lys 
    2075                 2080                 2085             


Pro Val  Ser Leu Ser Ser Ser  Tyr Phe His Arg Glu  Lys Ser Asn 
    2090                 2095                 2100             


Ile Phe  Ser Pro Gln Glu Leu  Pro Gly Ser His Val  Thr Glu Asp 
    2105                 2110                 2115             


Val Leu  Lys Val Ser Thr Ile  Pro Gly Pro Ala Gly  Gln Lys Thr 
    2120                 2125                 2130             


Val Leu  Pro Thr Ala Leu Pro  Ser Ser Phe Ser His  Arg Glu Lys 
    2135                 2140                 2145             


Pro Asp  Ile Phe Tyr Gln Lys  Asp Leu Pro Asp Arg  His Leu Thr 
    2150                 2155                 2160             


Glu Asp  Ala Leu Lys Ile Ser  Ser Ala Leu Gly Gln  Ala Asp Gln 
    2165                 2170                 2175             


Ile Thr  Gly Leu Gln Thr Val  Pro Ser Gly Thr Tyr  Ser His Gly 
    2180                 2185                 2190             


Glu Asn  His Lys Leu Val Ser  Glu His Val Gln Arg  Leu Ile Asp 
    2195                 2200                 2205             


Asn Leu  Asn Ser Ser Asp Ser  Ser Val Ser Ser Asn  Asn Val Leu 
    2210                 2215                 2220             


Leu Asn  Ser Gln Ala Asp Asp  Arg Val Val Ile Asn  Lys Pro Glu 
    2225                 2230                 2235             


Ser Ala  Gly Phe Arg Asp Val  Gly Ser Glu Glu Ile  Gln Asp Ala 
    2240                 2245                 2250             


Glu Asn  Ser Ala Lys Thr Leu  Lys Glu Ile Arg Thr  Leu Leu Met 
    2255                 2260                 2265             


Glu Ala  Glu Asn Met Ala Leu  Lys Arg Cys Asn Phe  Pro Ala Pro 
    2270                 2275                 2280             


Leu Ala  Arg Phe Arg Asp Ile  Ser Asp Ile Ser Phe  Ile Gln Ser 
    2285                 2290                 2295             


Lys Lys  Val Val Cys Phe Lys  Glu Pro Ser Ser Thr  Gly Val Ser 
    2300                 2305                 2310             


Asn Gly  Asp Leu Leu His Arg  Gln Pro Phe Thr Glu  Glu Ser Pro 
    2315                 2320                 2325             


Ser Ser  Arg Cys Ile Gln Lys  Asp Ile Gly Thr Gln  Thr Asn Leu 
    2330                 2335                 2340             


Lys Cys  Arg Arg Gly Ile Glu  Asn Trp Glu Phe Ile  Ser Ser Thr 
    2345                 2350                 2355             


Thr Val  Arg Ser Pro Leu Gln  Glu Ala Glu Ser Lys  Val Ser Met 
    2360                 2365                 2370             


Ala Leu  Glu Glu Thr Leu Arg  Gln Tyr Gln Ala Ala  Lys Ser Val 
    2375                 2380                 2385             


Met Arg  Ser Glu Pro Glu Gly  Cys Ser Gly Thr Ile  Gly Asn Lys 
    2390                 2395                 2400             


Ile Ile  Ile Pro Met Met Thr  Val Ile Lys Ser Asp  Ser Ser Ser 
    2405                 2410                 2415             


Asp Ala  Ser Asp Gly Asn Gly  Ser Cys Ser Trp Asp  Ser Asn Leu 
    2420                 2425                 2430             


Pro Glu  Ser Leu Glu Ser Val  Ser Asp Val Leu Leu  Asn Phe Phe 
    2435                 2440                 2445             


Pro Tyr  Val Ser Pro Lys Thr  Ser Ile Thr Asp Ser  Arg Glu Glu 
    2450                 2455                 2460             


Glu Gly  Val Ser Glu Ser Glu  Asp Gly Gly Gly Ser  Ser Val Asp 
    2465                 2470                 2475             


Ser Leu  Ala Ala His Val Lys  Asn Leu Leu Gln Cys  Glu Ser Ser 
    2480                 2485                 2490             


Leu Asn  His Ala Lys Glu Ile  Leu Arg Asn Ala Glu  Glu Glu Glu 
    2495                 2500                 2505             


Ser Arg  Val Arg Ala His Ala  Trp Asn Met Lys Phe  Asn Leu Ala 
    2510                 2515                 2520             


His Asp  Cys Gly Tyr Ser Ile  Ser Glu Leu Asn Glu  Asp Asp Arg 
    2525                 2530                 2535             


Arg Lys  Val Glu Glu Ile Lys  Ala Glu Leu Phe Gly  His Gly Arg 
    2540                 2545                 2550             


Thr Thr  Asp Leu Ser Lys Gly  Leu Gln Ser Pro Arg  Gly Met Gly 
    2555                 2560                 2565             


Cys Lys  Pro Glu Ala Val Cys  Ser His Ile Ile Ile  Glu Ser His 
    2570                 2575                 2580             


Glu Lys  Gly Cys Phe Arg Thr  Leu Thr Ser Glu His  Pro Gln Leu 
    2585                 2590                 2595             


Asp Arg  His Pro Cys Ala Phe  Arg Ser Ala Gly Pro  Ser Glu Met 
    2600                 2605                 2610             


Thr Arg  Gly Arg Gln Asn Pro  Ser Ser Cys Arg Ala  Lys His Val 
    2615                 2620                 2625             


Asn Leu  Ser Ala Ser Leu Asp  Gln Asn Asn Ser His  Phe Lys Val 
    2630                 2635                 2640             


Trp Asn  Ser Leu Gln Leu Lys  Ser His Ser Pro Phe  Gln Asn Phe 
    2645                 2650                 2655             


Ile Pro  Asp Glu Phe Lys Ile  Ser Lys Gly Leu Arg  Met Pro Phe 
    2660                 2665                 2670             


Asp Glu  Lys Met Asp Pro Trp  Leu Ser Glu Leu Val  Glu Pro Ala 
    2675                 2680                 2685             


Phe Val  Pro Pro Lys Glu Val  Asp Phe His Ser Ser  Ser Gln Met 
    2690                 2695                 2700             


Pro Ser  Pro Glu Pro Met Lys  Lys Phe Thr Thr Ser  Ile Thr Phe 
    2705                 2710                 2715             


Ser Ser  His Arg His Ser Lys  Cys Ile Ser Asn Ser  Ser Val Val 
    2720                 2725                 2730             


Lys Val  Gly Val Thr Glu Gly  Ser Gln Cys Thr Gly  Ala Ser Val 
    2735                 2740                 2745             


Gly Val  Phe Asn Ser His Phe  Thr Glu Glu Gln Asn  Pro Pro Arg 
    2750                 2755                 2760             


Asp Leu  Lys Gln Lys Thr Ser  Ser Pro Ser Ser Phe  Lys Met His 
    2765                 2770                 2775             


Ser Asn  Ser Gln Asp Lys Glu  Val Thr Ile Leu Ala  Glu Gly Arg 
    2780                 2785                 2790             


Arg Gln  Ser Gln Lys Leu Pro  Val Asp Phe Glu Arg  Ser Phe Gln 
    2795                 2800                 2805             


Glu Glu  Lys Pro Leu Glu Arg  Ser Asp Phe Thr Gly  Ser His Ser 
    2810                 2815                 2820             


Glu Pro  Ser Thr Arg Ala Asn  Cys Ser Asn Phe Lys  Glu Ile Gln 
    2825                 2830                 2835             


Ile Ser  Asp Asn His Thr Leu  Ile Ser Met Gly Arg  Pro Ser Ser 
    2840                 2845                 2850             


Thr Leu  Gly Val Asn Arg Ser  Ser Ser Arg Leu Gly  Val Lys Glu 
    2855                 2860                 2865             


Lys Asn  Val Thr Ile Thr Pro  Asp Leu Pro Ser Cys  Ile Phe Leu 
    2870                 2875                 2880             


Glu Gln  Arg Glu Leu Phe Glu  Gln Ser Lys Ala Pro  Arg Ala Asp 
    2885                 2890                 2895             


Asp His  Val Arg Lys His His  Ser Pro Ser Pro Gln  His Gln Asp 
    2900                 2905                 2910             


Tyr Val  Ala Pro Asp Leu Pro  Ser Cys Ile Phe Leu  Glu Gln Arg 
    2915                 2920                 2925             


Glu Leu  Phe Glu Gln Cys Lys  Ala Pro Tyr Val Asp  His Gln Met 
    2930                 2935                 2940             


Arg Glu  Asn His Ser Pro Leu  Pro Gln Gly Gln Asp  Ser Ile Ala 
    2945                 2950                 2955             


Ser Asp  Leu Pro Ser Pro Ile  Ser Leu Glu Gln Cys  Gln Ser Lys 
    2960                 2965                 2970             


Ala Pro  Gly Val Asp Asp Gln  Met Asn Lys His His  Phe Pro Leu 
    2975                 2980                 2985             


Pro Gln  Gly Gln Asp Cys Val  Val Glu Lys Asn Asn  Gln His Lys 
    2990                 2995                 3000             


Pro Lys  Ser His Ile Ser Asn  Ile Asn Val Glu Ala  Lys Phe Asn 
    3005                 3010                 3015             


Thr Val  Val Ser Gln Ser Ala  Pro Asn His Cys Thr  Leu Ala Ala 
    3020                 3025                 3030             


Ser Ala  Ser Thr Pro Pro Ser  Asn Arg Lys Ala Leu  Ser Cys Val 
    3035                 3040                 3045             


His Ile  Thr Leu Cys Pro Lys  Thr Ser Ser Lys Leu  Asp Ser Gly 
    3050                 3055                 3060             


Thr Leu  Asp Glu Arg Phe His  Ser Leu Asp Ala Ala  Ser Lys Ala 
    3065                 3070                 3075             


Arg Met  Asn Ser Glu Phe Asn  Phe Asp Leu His Thr  Val Ser Ser 
    3080                 3085                 3090             


Arg Ser  Leu Glu Pro Thr Ser  Lys Leu Leu Thr Ser  Lys Pro Val 
    3095                 3100                 3105             


Ala Gln  Asp Gln Glu Ser Leu  Gly Phe Leu Gly Pro  Lys Ser Ser 
    3110                 3115                 3120             


Leu Asp  Phe Gln Val Val Gln  Pro Ser Leu Pro Asp  Ser Asn Thr 
    3125                 3130                 3135             


Ile Thr  Gln Asp Leu Lys Thr  Ile Pro Ser Gln Asn  Ser Gln Ile 
    3140                 3145                 3150             


Val Thr  Ser Arg Gln Ile Gln  Val Asn Ile Ser Asp  Phe Glu Gly 
    3155                 3160                 3165             


His Ser  Asn Pro Glu Gly Thr  Pro Val Phe Ala Asp  Arg Leu Pro 
    3170                 3175                 3180             


Glu Lys  Met Lys Thr Pro Leu  Ser Ala Phe Ser Glu  Lys Leu Ser 
    3185                 3190                 3195             


Ser Asp  Ala Val Thr Gln Ile  Thr Thr Glu Ser Pro  Glu Lys Thr 
    3200                 3205                 3210             


Leu Phe  Ser Ser Glu Ile Phe  Ile Asn Ala Glu Asp  Arg Gly His 
    3215                 3220                 3225             


Glu Ile  Ile Glu Pro Gly Asn  Gln Lys Leu Arg Lys  Ala Pro Val 
    3230                 3235                 3240             


Lys Phe  Ala Ser Ser Ser Ser  Val Gln Gln Val Thr  Phe Ser Arg 
    3245                 3250                 3255             


Gly Thr  Asp Gly Gln Pro Leu  Leu Leu Pro Tyr Lys  Pro Ser Gly 
    3260                 3265                 3270             


Ser Thr  Lys Met Tyr Tyr Val  Pro Gln Leu Arg Gln  Ile Pro Pro 
    3275                 3280                 3285             


Ser Pro  Asp Ser Lys Ser Asp  Thr Thr Val Glu Ser  Ser His Ser 
    3290                 3295                 3300             


Gly Ser  Asn Asp Ala Ile Ala  Pro Asp Phe Pro Ala  Gln Val Leu 
    3305                 3310                 3315             


Gly Thr  Arg Asp Asp Asp Leu  Ser Ala Thr Val Asn  Ile Lys His 
    3320                 3325                 3330             


Lys Glu  Gly Ile Tyr Ser Lys  Arg Val Val Thr Lys  Ala Ser Leu 
    3335                 3340                 3345             


Pro Val  Gly Glu Lys Pro Leu  Gln Asn Glu Asn Ala  Asp Ala Ser 
    3350                 3355                 3360             


Val Gln  Val Leu Ile Thr Gly  Asp Glu Asn Leu Ser  Asp Lys Lys 
    3365                 3370                 3375             


Gln Gln  Glu Ile His Ser Thr  Arg Ala Val Thr Glu  Ala Ala Gln 
    3380                 3385                 3390             


Ala Lys  Glu Lys Glu Ser Leu  Gln Lys Asp Thr Ala  Asp Ser Ser 
    3395                 3400                 3405             


Ala Ala  Ala Ala Ala Glu His  Ser Ala Gln Val Gly  Asp Pro Glu 
    3410                 3415                 3420             


Met Lys  Asn Leu Pro Asp Thr  Lys Ala Ile Thr Gln  Lys Glu Glu 
    3425                 3430                 3435             


Ile His  Arg Lys Lys Thr Val  Pro Glu Glu Ala Trp  Pro Asn Asn 
    3440                 3445                 3450             


Lys Glu  Ser Leu Gln Ile Asn  Ile Glu Glu Ser Glu  Cys His Ser 
    3455                 3460                 3465             


Glu Phe  Glu Asn Thr Thr Arg  Ser Val Phe Arg Ser  Ala Lys Phe 
    3470                 3475                 3480             


Tyr Ile  His His Pro Val His  Leu Pro Ser Asp Gln  Asp Ile Cys 
    3485                 3490                 3495             


His Glu  Ser Leu Gly Lys Ser  Val Phe Met Arg His  Ser Trp Lys 
    3500                 3505                 3510             


Asp Phe  Phe Gln His His Pro  Asp Lys His Arg Glu  His Met Cys 
    3515                 3520                 3525             


Leu Pro  Leu Pro Tyr Gln Asn  Met Asp Lys Thr Lys  Thr Asp Tyr 
    3530                 3535                 3540             


Thr Arg  Ile Lys Ser Leu Ser  Ile Asn Val Asn Leu  Gly Asn Lys 
    3545                 3550                 3555             


Glu Val  Met Asp Thr Thr Lys  Ser Gln Val Arg Asp  Tyr Pro Lys 
    3560                 3565                 3570             


His Asn  Gly Gln Ile Ser Asp  Pro Gln Arg Asp Gln  Lys Val Thr 
    3575                 3580                 3585             


Pro Glu  Gln Thr Thr Gln His  Thr Val Ser Leu Asn  Glu Leu Trp 
    3590                 3595                 3600             


Asn Lys  Tyr Arg Glu Arg Gln  Arg Gln Gln Arg Gln  Pro Glu Leu 
    3605                 3610                 3615             


Gly Asp  Arg Lys Glu Leu Ser  Leu Val Asp Arg Leu  Asp Arg Leu 
    3620                 3625                 3630             


Ala Lys  Ile Leu Gln Asn Pro  Ile Thr His Ser Leu  Gln Val Ser 
    3635                 3640                 3645             


Glu Ser  Thr His Asp Asp Ser  Arg Gly Glu Arg Ser  Val Lys Glu 
    3650                 3655                 3660             


Trp Ser  Gly Arg Gln Gln Gln  Arg Asn Lys Leu Gln  Lys Lys Lys 
    3665                 3670                 3675             


Arg Phe  Lys Ser Leu Glu Lys  Ser His Lys Asn Thr  Gly Glu Leu 
    3680                 3685                 3690             


Lys Lys  Ser Lys Val Leu Ser  His His Arg Ala Gly  Arg Ser Asn 
    3695                 3700                 3705             


Gln Ile  Lys Ile Glu Gln Ile  Lys Phe Asp Lys Tyr  Ile Leu Ser 
    3710                 3715                 3720             


Lys Gln  Pro Gly Phe Asn Tyr  Ile Ser Asn Thr Ser  Ser Asp Cys 
    3725                 3730                 3735             


Arg Pro  Ser Glu Glu Ser Glu  Leu Leu Thr Asp Thr  Thr Thr Asn 
    3740                 3745                 3750             


Ile Leu  Ser Gly Thr Thr Ser  Thr Val Glu Ser Asp  Ile Leu Thr 
    3755                 3760                 3765             


Gln Thr  Asp Arg Glu Val Ala  Leu His Glu Arg Ser  Ser Ser Val 
    3770                 3775                 3780             


Ser Thr  Ile Asp Thr Ala Arg  Leu Ile Gln Ala Phe  Gly His Glu 
    3785                 3790                 3795             


Arg Val  Cys Leu Ser Pro Arg  Arg Ile Lys Leu Tyr  Ser Ser Ile 
    3800                 3805                 3810             


Thr Asn  Gln Gln Arg Arg Tyr  Leu Glu Lys Arg Ser  Lys His Ser 
    3815                 3820                 3825             


Lys Lys  Val Leu Asn Thr Gly  His Pro Leu Val Thr  Ser Glu His 
    3830                 3835                 3840             


Thr Arg  Arg Arg His Ile Gln  Val Ala Asn His Val  Ile Ser Ser 
    3845                 3850                 3855             


Asp Ser  Ile Ser Ser Ser Ala  Ser Ser Phe Leu Ser  Ser Asn Ser 
    3860                 3865                 3870             


Thr Phe  Cys Asn Lys Gln Asn  Val His Met Leu Asn  Lys Gly Ile 
    3875                 3880                 3885             


Gln Ala  Gly Asn Leu Glu Ile  Val Asn Gly Ala Lys  Lys His Thr 
    3890                 3895                 3900             


Arg Asp  Val Gly Ile Thr Phe  Pro Thr Pro Ser Ser  Ser Glu Ala 
    3905                 3910                 3915             


Lys Leu  Glu Glu Asn Ser Asp  Val Thr Ser Trp Ser  Glu Glu Lys 
    3920                 3925                 3930             


Arg Glu  Glu Lys Met Leu Phe  Thr Gly Tyr Pro Glu  Asp Arg Lys 
    3935                 3940                 3945             


Leu Lys  Lys Asn Lys Lys Asn  Ser His Glu Gly Val  Ser Trp Phe 
    3950                 3955                 3960             


Val Pro  Val Glu Asn Val Glu  Ser Arg Ser Lys Lys  Glu Asn Val 
    3965                 3970                 3975             


Pro Asn  Thr Cys Gly Pro Gly  Ile Ser Trp Phe Glu  Pro Ile Thr 
    3980                 3985                 3990             


Lys Thr  Arg Pro Trp Arg Glu  Pro Leu Arg Glu Gln  Asn Cys Gln 
    3995                 4000                 4005             


Gly Gln  His Leu Asp Gly Arg  Gly Tyr Leu Ala Gly  Pro Gly Arg 
    4010                 4015                 4020             


Glu Ala  Gly Arg Asp Leu Leu  Arg Pro Phe Val Arg  Ala Thr Leu 
    4025                 4030                 4035             


Gln Glu  Ser Leu Gln Phe His  Arg Pro Asp Phe Ile  Ser Arg Ser 
    4040                 4045                 4050             


Gly Glu  Arg Ile Lys Arg Leu  Lys Leu Ile Val Gln  Glu Arg Lys 
    4055                 4060                 4065             


Leu Gln  Ser Met Leu Gln Thr  Glu Arg Asp Ala Leu  Phe Asn Ile 
    4070                 4075                 4080             


Asp Arg  Glu Arg Gln Gly His  Gln Asn Arg Met Cys  Pro Leu Pro 
    4085                 4090                 4095             


Lys Arg  Val Phe Leu Ala Ile  Gln Lys Asn Lys Pro  Ile Ser Lys 
    4100                 4105                 4110             


Lys Glu  Met Ile Gln Arg Ser  Lys Arg Ile Tyr Glu  Gln Leu Pro 
    4115                 4120                 4125             


Glu Val  Gln Lys Lys Arg Glu  Glu Glu Lys Arg Lys  Ser Glu Tyr 
    4130                 4135                 4140             


Lys Ser  Tyr Arg Leu Arg Ala  Gln Leu Tyr Lys Lys  Arg Val Thr 
    4145                 4150                 4155             


Asn Gln  Leu Leu Gly Arg Lys  Val Pro Trp Asp 
    4160                 4165                 


<210>  464
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALOX12B__Homo_sapiens__NP_001130

<400>  464

Met Ala Thr Tyr Lys Val Arg Val Ala Thr Gly Thr Asp Leu Leu Ser 
1               5                   10                  15      


Gly Thr Arg Asp Ser Ile Ser Leu Thr Ile Val Gly Thr Gln Gly Glu 
            20                  25                  30          


Ser His Lys Gln Leu Leu Asn His Phe Gly Arg Asp Phe Ala Thr Gly 
        35                  40                  45              


Ala Val Gly Gln Tyr Thr Val Gln Cys Pro Gln Asp Leu Gly Glu Leu 
    50                  55                  60                  


Ile Ile Ile Arg Leu His Lys Glu Arg Tyr Ala Phe Phe Pro Lys Asp 
65                  70                  75                  80  


Pro Trp Tyr Cys Asn Tyr Val Gln Ile Cys Ala Pro Asn Gly Arg Ile 
                85                  90                  95      


Tyr His Phe Pro Ala Tyr Gln Trp Met Asp Gly Tyr Glu Thr Leu Ala 
            100                 105                 110         


Leu Arg Glu Ala Thr Gly Lys Thr Thr Ala Asp Asp Ser Leu Pro Val 
        115                 120                 125             


Leu Leu Glu His Arg Lys Glu Glu Ile Arg Ala Lys Gln Asp Phe Tyr 
    130                 135                 140                 


His Trp Arg Val Phe Leu Pro Gly Leu Pro Ser Tyr Val His Ile Pro 
145                 150                 155                 160 


Ser Tyr Arg Pro Pro Val Arg Arg His Arg Asn Pro Asn Arg Pro Glu 
                165                 170                 175     


Trp Asn Gly Tyr Ile Pro Gly Phe Pro Ile Leu Ile Asn Phe Lys Ala 
            180                 185                 190         


Thr Lys Phe Leu Asn Leu Asn Leu Arg Tyr Ser Phe Leu Lys Thr Ala 
        195                 200                 205             


Ser Phe Phe Val Arg Leu Gly Pro Met Ala Leu Ala Phe Lys Val Arg 
    210                 215                 220                 


Gly Leu Leu Asp Cys Lys His Ser Trp Lys Arg Leu Lys Asp Ile Arg 
225                 230                 235                 240 


Lys Ile Phe Pro Gly Lys Lys Ser Val Val Ser Glu Tyr Val Ala Glu 
                245                 250                 255     


His Trp Ala Glu Asp Thr Phe Phe Gly Tyr Gln Tyr Leu Asn Gly Val 
            260                 265                 270         


Asn Pro Gly Leu Ile Arg Arg Cys Thr Arg Ile Pro Asp Lys Phe Pro 
        275                 280                 285             


Val Thr Asp Asp Met Val Ala Pro Phe Leu Gly Glu Gly Thr Cys Leu 
    290                 295                 300                 


Gln Ala Glu Leu Glu Lys Gly Asn Ile Tyr Leu Ala Asp Tyr Arg Ile 
305                 310                 315                 320 


Met Glu Gly Ile Pro Thr Val Glu Leu Ser Gly Arg Lys Gln His His 
                325                 330                 335     


Cys Ala Pro Leu Cys Leu Leu His Phe Gly Pro Glu Gly Lys Met Met 
            340                 345                 350         


Pro Ile Ala Ile Gln Leu Ser Gln Thr Pro Gly Pro Asp Cys Pro Ile 
        355                 360                 365             


Phe Leu Pro Ser Asp Ser Glu Trp Asp Trp Leu Leu Ala Lys Thr Trp 
    370                 375                 380                 


Val Arg Tyr Ala Glu Phe Tyr Ser His Glu Ala Ile Ala His Leu Leu 
385                 390                 395                 400 


Glu Thr His Leu Ile Ala Glu Ala Phe Cys Leu Ala Leu Leu Arg Asn 
                405                 410                 415     


Leu Pro Met Cys His Pro Leu Tyr Lys Leu Leu Ile Pro His Thr Arg 
            420                 425                 430         


Tyr Thr Val Gln Ile Asn Ser Ile Gly Arg Ala Val Leu Leu Asn Glu 
        435                 440                 445             


Gly Gly Leu Ser Ala Lys Gly Met Ser Leu Gly Val Glu Gly Phe Ala 
    450                 455                 460                 


Gly Val Met Val Arg Ala Leu Ser Glu Leu Thr Tyr Asp Ser Leu Tyr 
465                 470                 475                 480 


Leu Pro Asn Asp Phe Val Glu Arg Gly Val Gln Asp Leu Pro Gly Tyr 
                485                 490                 495     


Tyr Tyr Arg Asp Asp Ser Leu Ala Val Trp Asn Ala Leu Glu Lys Tyr 
            500                 505                 510         


Val Thr Glu Ile Ile Thr Tyr Tyr Tyr Pro Ser Asp Ala Ala Val Glu 
        515                 520                 525             


Gly Asp Pro Glu Leu Gln Ser Trp Val Gln Glu Ile Phe Lys Glu Cys 
    530                 535                 540                 


Leu Leu Gly Arg Glu Ser Ser Gly Phe Pro Arg Cys Leu Arg Thr Val 
545                 550                 555                 560 


Pro Glu Leu Ile Arg Tyr Val Thr Ile Val Ile Tyr Thr Cys Ser Ala 
                565                 570                 575     


Lys His Ala Ala Val Asn Thr Gly Gln Met Glu Phe Thr Ala Trp Met 
            580                 585                 590         


Pro Asn Phe Pro Ala Ser Met Arg Asn Pro Pro Ile Gln Thr Lys Gly 
        595                 600                 605             


Leu Thr Thr Leu Glu Thr Phe Met Asp Thr Leu Pro Asp Val Lys Thr 
    610                 615                 620                 


Thr Cys Ile Thr Leu Leu Val Leu Trp Thr Leu Ser Arg Glu Pro Asp 
625                 630                 635                 640 


Asp Arg Arg Pro Leu Gly His Phe Pro Asp Ile His Phe Val Glu Glu 
                645                 650                 655     


Ala Pro Arg Arg Ser Ile Glu Ala Phe Arg Gln Arg Leu Asn Gln Ile 
            660                 665                 670         


Ser His Asp Ile Arg Gln Arg Asn Lys Cys Leu Pro Ile Pro Tyr Tyr 
        675                 680                 685             


Tyr Leu Asp Pro Val Leu Ile Glu Asn Ser Ile Ser Ile 
    690                 695                 700     


<210>  465
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALOX12__Homo_sapiens__NP_000688

<400>  465

Met Gly Arg Tyr Arg Ile Arg Val Ala Thr Gly Ala Trp Leu Phe Ser 
1               5                   10                  15      


Gly Ser Tyr Asn Arg Val Gln Leu Trp Leu Val Gly Thr Arg Gly Glu 
            20                  25                  30          


Ala Glu Leu Glu Leu Gln Leu Arg Pro Ala Arg Gly Glu Glu Glu Glu 
        35                  40                  45              


Phe Asp His Asp Val Ala Glu Asp Leu Gly Leu Leu Gln Phe Val Arg 
    50                  55                  60                  


Leu Arg Lys His His Trp Leu Val Asp Asp Ala Trp Phe Cys Asp Arg 
65                  70                  75                  80  


Ile Thr Val Gln Gly Pro Gly Ala Cys Ala Glu Val Ala Phe Pro Cys 
                85                  90                  95      


Tyr Arg Trp Val Gln Gly Glu Asp Ile Leu Ser Leu Pro Glu Gly Thr 
            100                 105                 110         


Ala Arg Leu Pro Gly Asp Asn Ala Leu Asp Met Phe Gln Lys His Arg 
        115                 120                 125             


Glu Lys Glu Leu Lys Asp Arg Gln Gln Ile Tyr Cys Trp Ala Thr Trp 
    130                 135                 140                 


Lys Glu Gly Leu Pro Leu Thr Ile Ala Ala Asp Arg Lys Asp Asp Leu 
145                 150                 155                 160 


Pro Pro Asn Met Arg Phe His Glu Glu Lys Arg Leu Asp Phe Glu Trp 
                165                 170                 175     


Thr Leu Lys Ala Gly Ala Leu Glu Met Ala Leu Lys Arg Val Tyr Thr 
            180                 185                 190         


Leu Leu Ser Ser Trp Asn Cys Leu Glu Asp Phe Asp Gln Ile Phe Trp 
        195                 200                 205             


Gly Gln Lys Ser Ala Leu Ala Glu Lys Val Arg Gln Cys Trp Gln Asp 
    210                 215                 220                 


Asp Glu Leu Phe Ser Tyr Gln Phe Leu Asn Gly Ala Asn Pro Met Leu 
225                 230                 235                 240 


Leu Arg Arg Ser Thr Ser Leu Pro Ser Arg Leu Val Leu Pro Ser Gly 
                245                 250                 255     


Met Glu Glu Leu Gln Ala Gln Leu Glu Lys Glu Leu Gln Asn Gly Ser 
            260                 265                 270         


Leu Phe Glu Ala Asp Phe Ile Leu Leu Asp Gly Ile Pro Ala Asn Val 
        275                 280                 285             


Ile Arg Gly Glu Lys Gln Tyr Leu Ala Ala Pro Leu Val Met Leu Lys 
    290                 295                 300                 


Met Glu Pro Asn Gly Lys Leu Gln Pro Met Val Ile Gln Ile Gln Pro 
305                 310                 315                 320 


Pro Asn Pro Ser Ser Pro Thr Pro Thr Leu Phe Leu Pro Ser Asp Pro 
                325                 330                 335     


Pro Leu Ala Trp Leu Leu Ala Lys Ser Trp Val Arg Asn Ser Asp Phe 
            340                 345                 350         


Gln Leu His Glu Ile Gln Tyr His Leu Leu Asn Thr His Leu Val Ala 
        355                 360                 365             


Glu Val Ile Ala Val Ala Thr Met Arg Cys Leu Pro Gly Leu His Pro 
    370                 375                 380                 


Ile Phe Lys Phe Leu Ile Pro His Ile Arg Tyr Thr Met Glu Ile Asn 
385                 390                 395                 400 


Thr Arg Ala Arg Thr Gln Leu Ile Ser Asp Gly Gly Ile Phe Asp Lys 
                405                 410                 415     


Ala Val Ser Thr Gly Gly Gly Gly His Val Gln Leu Leu Arg Arg Ala 
            420                 425                 430         


Ala Ala Gln Leu Thr Tyr Cys Ser Leu Cys Pro Pro Asp Asp Leu Ala 
        435                 440                 445             


Asp Arg Gly Leu Leu Gly Leu Pro Gly Ala Leu Tyr Ala His Asp Ala 
    450                 455                 460                 


Leu Arg Leu Trp Glu Ile Ile Ala Arg Tyr Val Glu Gly Ile Val His 
465                 470                 475                 480 


Leu Phe Tyr Gln Arg Asp Asp Ile Val Lys Gly Asp Pro Glu Leu Gln 
                485                 490                 495     


Ala Trp Cys Arg Glu Ile Thr Glu Val Gly Leu Cys Gln Ala Gln Asp 
            500                 505                 510         


Arg Gly Phe Pro Val Ser Phe Gln Ser Gln Ser Gln Leu Cys His Phe 
        515                 520                 525             


Leu Thr Met Cys Val Phe Thr Cys Thr Ala Gln His Ala Ala Ile Asn 
    530                 535                 540                 


Gln Gly Gln Leu Asp Trp Tyr Ala Trp Val Pro Asn Ala Pro Cys Thr 
545                 550                 555                 560 


Met Arg Met Pro Pro Pro Thr Thr Lys Glu Asp Val Thr Met Ala Thr 
                565                 570                 575     


Val Met Gly Ser Leu Pro Asp Val Arg Gln Ala Cys Leu Gln Met Ala 
            580                 585                 590         


Ile Ser Trp His Leu Ser Arg Arg Gln Pro Asp Met Val Pro Leu Gly 
        595                 600                 605             


His His Lys Glu Lys Tyr Phe Ser Gly Pro Lys Pro Lys Ala Val Leu 
    610                 615                 620                 


Asn Gln Phe Arg Thr Asp Leu Glu Lys Leu Glu Lys Glu Ile Thr Ala 
625                 630                 635                 640 


Arg Asn Glu Gln Leu Asp Trp Pro Tyr Glu Tyr Leu Lys Pro Ser Cys 
                645                 650                 655     


Ile Glu Asn Ser Val Thr Ile 
            660             


<210>  466
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALOX15B__Homo_sapiens__NP_001034219

<400>  466

Met Ala Glu Phe Arg Val Arg Val Ser Thr Gly Glu Ala Phe Gly Ala 
1               5                   10                  15      


Gly Thr Trp Asp Lys Val Ser Val Ser Ile Val Gly Thr Arg Gly Glu 
            20                  25                  30          


Ser Pro Pro Leu Pro Leu Asp Asn Leu Gly Lys Glu Phe Thr Ala Gly 
        35                  40                  45              


Ala Glu Glu Asp Phe Gln Val Thr Leu Pro Glu Asp Val Gly Arg Val 
    50                  55                  60                  


Leu Leu Leu Arg Val His Lys Ala Pro Pro Val Leu Pro Leu Leu Gly 
65                  70                  75                  80  


Pro Leu Ala Pro Asp Ala Trp Phe Cys Arg Trp Phe Gln Leu Thr Pro 
                85                  90                  95      


Pro Arg Gly Gly His Leu Leu Phe Pro Cys Tyr Gln Trp Leu Glu Gly 
            100                 105                 110         


Ala Gly Thr Leu Val Leu Gln Glu Gly Thr Ala Lys Val Ser Trp Ala 
        115                 120                 125             


Asp His His Pro Val Leu Gln Gln Gln Arg Gln Glu Glu Leu Gln Ala 
    130                 135                 140                 


Arg Gln Glu Met Tyr Gln Trp Lys Ala Tyr Asn Pro Gly Trp Pro His 
145                 150                 155                 160 


Cys Leu Asp Glu Lys Thr Val Glu Asp Leu Glu Leu Asn Ile Lys Tyr 
                165                 170                 175     


Ser Thr Ala Lys Asn Ala Asn Phe Tyr Leu Gln Ala Gly Ser Ala Phe 
            180                 185                 190         


Ala Glu Met Lys Ile Lys Gly Leu Leu Asp Arg Lys Gly Leu Trp Arg 
        195                 200                 205             


Ser Leu Asn Glu Met Lys Arg Ile Phe Asn Phe Arg Arg Thr Pro Ala 
    210                 215                 220                 


Ala Glu His Ala Phe Glu His Trp Gln Glu Asp Ala Phe Phe Ala Ser 
225                 230                 235                 240 


Gln Phe Leu Asn Gly Leu Asn Pro Val Leu Ile Arg Arg Cys His Tyr 
                245                 250                 255     


Leu Pro Lys Asn Phe Pro Val Thr Asp Ala Met Val Ala Ser Val Leu 
            260                 265                 270         


Gly Pro Gly Thr Ser Leu Gln Ala Glu Leu Glu Lys Gly Ser Leu Phe 
        275                 280                 285             


Leu Val Asp His Gly Ile Leu Ser Gly Ile Gln Thr Asn Val Ile Asn 
    290                 295                 300                 


Gly Lys Pro Gln Phe Ser Ala Ala Pro Met Thr Leu Leu Tyr Gln Ser 
305                 310                 315                 320 


Pro Gly Cys Gly Pro Leu Leu Pro Leu Ala Ile Gln Leu Ser Gln Thr 
                325                 330                 335     


Pro Gly Pro Asn Ser Pro Ile Phe Leu Pro Thr Asp Asp Lys Trp Asp 
            340                 345                 350         


Trp Leu Leu Ala Lys Thr Trp Val Arg Asn Ala Glu Phe Ser Phe His 
        355                 360                 365             


Glu Ala Leu Thr His Leu Leu His Ser His Leu Leu Pro Glu Val Phe 
    370                 375                 380                 


Thr Leu Ala Thr Leu Arg Gln Leu Pro His Cys His Pro Leu Phe Lys 
385                 390                 395                 400 


Ser Thr Gly Ile Gly Ile Glu Gly Phe Ser Glu Leu Ile Gln Arg Asn 
                405                 410                 415     


Met Lys Gln Leu Asn Tyr Ser Leu Leu Cys Leu Pro Glu Asp Ile Arg 
            420                 425                 430         


Thr Arg Gly Val Glu Asp Ile Pro Gly Tyr Tyr Tyr Arg Asp Asp Gly 
        435                 440                 445             


Met Gln Ile Trp Gly Ala Val Glu Arg Phe Val Ser Glu Ile Ile Gly 
    450                 455                 460                 


Ile Tyr Tyr Pro Ser Asp Glu Ser Val Gln Asp Asp Arg Glu Leu Gln 
465                 470                 475                 480 


Ala Trp Val Arg Glu Ile Phe Ser Lys Gly Phe Leu Asn Gln Glu Ser 
                485                 490                 495     


Ser Gly Ile Pro Ser Ser Leu Glu Thr Arg Glu Ala Leu Val Gln Tyr 
            500                 505                 510         


Val Thr Met Val Ile Phe Thr Cys Ser Ala Lys His Ala Ala Val Ser 
        515                 520                 525             


Ala Gly Gln Phe Asp Ser Cys Ala Trp Met Pro Asn Leu Pro Pro Ser 
    530                 535                 540                 


Met Gln Leu Pro Pro Pro Thr Ser Lys Gly Leu Ala Thr Cys Glu Gly 
545                 550                 555                 560 


Phe Ile Ala Thr Leu Pro Pro Val Asn Ala Thr Cys Asp Val Ile Leu 
                565                 570                 575     


Ala Leu Trp Leu Leu Ser Lys Glu Pro Gly Asp Gln Arg Pro Leu Gly 
            580                 585                 590         


Thr Tyr Pro Asp Glu His Phe Thr Glu Glu Ala Pro Arg Arg Ser Ile 
        595                 600                 605             


Ala Thr Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg Gly Ile Gln Glu 
    610                 615                 620                 


Arg Asn Gln Gly Leu Val Leu Pro Tyr Thr Tyr Leu Asp Pro Pro Leu 
625                 630                 635                 640 


Ile Glu Asn Ser Val Ser Ile 
                645         


<210>  467
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALOX15__Homo_sapiens__NP_001131

<400>  467

Met Gly Leu Tyr Arg Ile Arg Val Ser Thr Gly Ala Ser Leu Tyr Ala 
1               5                   10                  15      


Gly Ser Asn Asn Gln Val Gln Leu Trp Leu Val Gly Gln His Gly Glu 
            20                  25                  30          


Ala Ala Leu Gly Lys Arg Leu Trp Pro Ala Arg Gly Lys Glu Thr Glu 
        35                  40                  45              


Leu Lys Val Glu Val Pro Glu Tyr Leu Gly Pro Leu Leu Phe Val Lys 
    50                  55                  60                  


Leu Arg Lys Arg His Leu Leu Lys Asp Asp Ala Trp Phe Cys Asn Trp 
65                  70                  75                  80  


Ile Ser Val Gln Gly Pro Gly Ala Gly Asp Glu Val Arg Phe Pro Cys 
                85                  90                  95      


Tyr Arg Trp Val Glu Gly Asn Gly Val Leu Ser Leu Pro Glu Gly Thr 
            100                 105                 110         


Gly Arg Thr Val Gly Glu Asp Pro Gln Gly Leu Phe Gln Lys His Arg 
        115                 120                 125             


Glu Glu Glu Leu Glu Glu Arg Arg Lys Leu Tyr Arg Trp Gly Asn Trp 
    130                 135                 140                 


Lys Asp Gly Leu Ile Leu Asn Met Ala Gly Ala Lys Leu Tyr Asp Leu 
145                 150                 155                 160 


Pro Val Asp Glu Arg Phe Leu Glu Asp Lys Arg Val Asp Phe Glu Val 
                165                 170                 175     


Ser Leu Ala Lys Gly Leu Ala Asp Leu Ala Ile Lys Asp Ser Leu Asn 
            180                 185                 190         


Val Leu Thr Cys Trp Lys Asp Leu Asp Asp Phe Asn Arg Ile Phe Trp 
        195                 200                 205             


Cys Gly Gln Ser Lys Leu Ala Glu Arg Val Arg Asp Ser Trp Lys Glu 
    210                 215                 220                 


Asp Ala Leu Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Val Val 
225                 230                 235                 240 


Leu Arg Arg Ser Ala His Leu Pro Ala Arg Leu Val Phe Pro Pro Gly 
                245                 250                 255     


Met Glu Glu Leu Gln Ala Gln Leu Glu Lys Glu Leu Glu Gly Gly Thr 
            260                 265                 270         


Leu Phe Glu Ala Asp Phe Ser Leu Leu Asp Gly Ile Lys Ala Asn Val 
        275                 280                 285             


Ile Leu Cys Ser Gln Gln His Leu Ala Ala Pro Leu Val Met Leu Lys 
    290                 295                 300                 


Leu Gln Pro Asp Gly Lys Leu Leu Pro Met Val Ile Gln Leu Gln Leu 
305                 310                 315                 320 


Pro Arg Thr Gly Ser Pro Pro Pro Pro Leu Phe Leu Pro Thr Asp Pro 
                325                 330                 335     


Pro Met Ala Trp Leu Leu Ala Lys Cys Trp Val Arg Ser Ser Asp Phe 
            340                 345                 350         


Gln Leu His Glu Leu Gln Ser His Leu Leu Arg Gly His Leu Met Ala 
        355                 360                 365             


Glu Val Ile Val Val Ala Thr Met Arg Cys Leu Pro Ser Ile His Pro 
    370                 375                 380                 


Ile Phe Lys Leu Ile Ile Pro His Leu Arg Tyr Thr Leu Glu Ile Asn 
385                 390                 395                 400 


Val Arg Ala Arg Thr Gly Leu Val Ser Asp Met Gly Ile Phe Asp Gln 
                405                 410                 415     


Ile Met Ser Thr Gly Gly Gly Gly His Val Gln Leu Leu Lys Gln Ala 
            420                 425                 430         


Gly Ala Phe Leu Thr Tyr Ser Ser Phe Cys Pro Pro Asp Asp Leu Ala 
        435                 440                 445             


Asp Arg Gly Leu Leu Gly Val Lys Ser Ser Phe Tyr Ala Gln Asp Ala 
    450                 455                 460                 


Leu Arg Leu Trp Glu Ile Ile Tyr Arg Tyr Val Glu Gly Ile Val Ser 
465                 470                 475                 480 


Leu His Tyr Lys Thr Asp Val Ala Val Lys Asp Asp Pro Glu Leu Gln 
                485                 490                 495     


Thr Trp Cys Arg Glu Ile Thr Glu Ile Gly Leu Gln Gly Ala Gln Asp 
            500                 505                 510         


Arg Gly Phe Pro Val Ser Leu Gln Ala Arg Asp Gln Val Cys His Phe 
        515                 520                 525             


Val Thr Met Cys Ile Phe Thr Cys Thr Gly Gln His Ala Ser Val His 
    530                 535                 540                 


Leu Gly Gln Leu Asp Trp Tyr Ser Trp Val Pro Asn Ala Pro Cys Thr 
545                 550                 555                 560 


Met Arg Leu Pro Pro Pro Thr Thr Lys Asp Ala Thr Leu Glu Thr Val 
                565                 570                 575     


Met Ala Thr Leu Pro Asn Phe His Gln Ala Ser Leu Gln Met Ser Ile 
            580                 585                 590         


Thr Trp Gln Leu Gly Arg Arg Gln Pro Val Met Val Ala Val Gly Gln 
        595                 600                 605             


His Glu Glu Glu Tyr Phe Ser Gly Pro Glu Pro Lys Ala Val Leu Lys 
    610                 615                 620                 


Lys Phe Arg Glu Glu Leu Ala Ala Leu Asp Lys Glu Ile Glu Ile Arg 
625                 630                 635                 640 


Asn Ala Lys Leu Asp Met Pro Tyr Glu Tyr Leu Arg Pro Ser Val Val 
                645                 650                 655     


Glu Asn Ser Val Ala Ile 
            660         


<210>  468
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALOX5AP__Homo_sapiens__NP_001191335

<400>  468

Met Leu Thr Phe Asn His Asp Ala Pro Trp His Thr Gln Lys Thr Leu 
1               5                   10                  15      


Lys Thr Ser Glu Phe Gly Lys Ser Phe Gly Thr Leu Gly His Ile Gly 
            20                  25                  30          


Asn Ile Ser His Gln Cys Trp Ala Gly Cys Ala Ala Gly Gly Arg Ala 
        35                  40                  45              


Val Leu Ser Gly Glu Pro Glu Ala Asn Met Asp Gln Glu Thr Val Gly 
    50                  55                  60                  


Asn Val Val Leu Leu Ala Ile Val Thr Leu Ile Ser Val Val Gln Asn 
65                  70                  75                  80  


Gly Phe Phe Ala His Lys Val Glu His Glu Ser Arg Thr Gln Asn Gly 
                85                  90                  95      


Arg Ser Phe Gln Arg Thr Gly Thr Leu Ala Phe Glu Arg Val Tyr Thr 
            100                 105                 110         


Ala Asn Gln Asn Cys Val Asp Ala Tyr Pro Thr Phe Leu Ala Val Leu 
        115                 120                 125             


Trp Ser Ala Gly Leu Leu Cys Ser Gln Val Pro Ala Ala Phe Ala Gly 
    130                 135                 140                 


Leu Met Tyr Leu Phe Val Arg Gln Lys Tyr Phe Val Gly Tyr Leu Gly 
145                 150                 155                 160 


Glu Arg Thr Gln Ser Thr Pro Gly Tyr Ile Phe Gly Lys Arg Ile Ile 
                165                 170                 175     


Leu Phe Leu Phe Leu Met Ser Val Ala Gly Ile Phe Asn Tyr Tyr Leu 
            180                 185                 190         


Ile Phe Phe Phe Gly Ser Asp Phe Glu Asn Tyr Ile Lys Thr Ile Ser 
        195                 200                 205             


Thr Thr Ile Ser Pro Leu Leu Leu Ile Pro 
    210                 215             


<210>  469
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALOX5__Homo_sapiens__NP_000689

<400>  469

Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser Gln Trp Phe Ala 
1               5                   10                  15      


Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly Ser Ala Gly Cys 
            20                  25                  30          


Ser Glu Lys His Leu Leu Asp Lys Pro Phe Tyr Asn Asp Phe Glu Arg 
        35                  40                  45              


Gly Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly Glu 
    50                  55                  60                  


Ile Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Trp Leu Asn Asp Asp 
65                  70                  75                  80  


Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr Ile 
                85                  90                  95      


Glu Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val Leu 
            100                 105                 110         


Arg Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile Leu 
        115                 120                 125             


Lys Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr Arg 
    130                 135                 140                 


Trp Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys Cys 
145                 150                 155                 160 


His Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly Val 
                165                 170                 175     


Asp Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile Asn 
            180                 185                 190         


Arg Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp Phe 
        195                 200                 205             


Glu Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val Met 
    210                 215                 220                 


Asn His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn Gly 
225                 230                 235                 240 


Cys Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys Leu 
                245                 250                 255     


Pro Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu Ser 
            260                 265                 270         


Leu Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe Glu 
        275                 280                 285             


Leu Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu Gln 
    290                 295                 300                 


Phe Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn Lys 
305                 310                 315                 320 


Ile Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu Asn 
                325                 330                 335     


Pro Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala Lys 
            340                 345                 350         


Ile Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr His 
        355                 360                 365             


Leu Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met Tyr 
    370                 375                 380                 


Arg Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala His 
385                 390                 395                 400 


Val Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu Ile 
                405                 410                 415     


Cys Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly Gly 
            420                 425                 430         


His Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala Ser 
        435                 440                 445             


Leu Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys Glu 
    450                 455                 460                 


Asp Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp Glu 
465                 470                 475                 480 


Ala Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu Gly 
                485                 490                 495     


Asp Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn Asp 
            500                 505                 510         


Val Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro Lys 
        515                 520                 525             


Ser Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val Ile 
    530                 535                 540                 


Phe Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr Asp 
545                 550                 555                 560 


Trp Cys Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro Pro 
                565                 570                 575     


Pro Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr Leu 
            580                 585                 590         


Pro Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala Leu 
        595                 600                 605             


Ser Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu Glu 
    610                 615                 620                 


His Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg Lys 
625                 630                 635                 640 


Asn Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Lys Lys Lys 
                645                 650                 655     


Gln Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val 
            660                 665                 670         


Ala Ile 
        


<210>  470
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALOXE3__Homo_sapiens__NP_001159432

<400>  470

Met Pro Arg Gly Ala Phe Arg Pro Cys Leu Pro Ala Leu Tyr Phe Ala 
1               5                   10                  15      


Phe Leu Thr Cys Pro Thr Pro Glu Gln Arg Met Ser Gly Thr Gln Ala 
            20                  25                  30          


Pro Asp Ile His Leu Gly Glu Pro Ala Arg Gly Thr Gly Cys Val Arg 
        35                  40                  45              


Gly Lys Gln Thr Ser Ile Arg Val Gln Asp Cys Gly Arg Arg Glu Glu 
    50                  55                  60                  


Ala Arg Ala Ala Ser Arg Glu Leu Arg Arg Glu Lys Ala Gln Glu His 
65                  70                  75                  80  


Pro Arg Glu Ser Trp Ala His Pro Gln Pro Tyr Pro Ala Pro Gln Pro 
                85                  90                  95      


Leu Ala Leu Arg Pro Glu Thr Gln Pro Cys Pro Ala Cys Arg Ser Ser 
            100                 105                 110         


Pro Pro Gly Arg Leu Leu Leu Arg Pro Ala Leu Pro Gly His Pro Phe 
        115                 120                 125             


Leu Leu Pro Ile Met Ala Val Tyr Arg Leu Cys Val Thr Thr Gly Pro 
    130                 135                 140                 


Tyr Leu Arg Ala Gly Thr Leu Asp Asn Ile Ser Val Thr Leu Val Gly 
145                 150                 155                 160 


Thr Cys Gly Glu Ser Pro Lys Gln Arg Leu Asp Arg Met Gly Arg Asp 
                165                 170                 175     


Phe Ala Pro Gly Ser Val Gln Lys Tyr Lys Val Arg Cys Thr Ala Glu 
            180                 185                 190         


Leu Gly Glu Leu Leu Leu Leu Arg Val His Lys Glu Arg Tyr Ala Phe 
        195                 200                 205             


Phe Arg Lys Asp Ser Trp Tyr Cys Ser Arg Ile Cys Val Thr Glu Pro 
    210                 215                 220                 


Asp Gly Ser Val Ser His Phe Pro Cys Tyr Gln Trp Ile Glu Gly Tyr 
225                 230                 235                 240 


Cys Thr Val Glu Leu Arg Pro Gly Thr Ala Arg Thr Ile Cys Gln Asp 
                245                 250                 255     


Ser Leu Pro Leu Leu Leu Asp His Arg Thr Arg Glu Leu Arg Ala Arg 
            260                 265                 270         


Gln Glu Cys Tyr Arg Trp Lys Ile Tyr Ala Pro Gly Phe Pro Cys Met 
        275                 280                 285             


Val Asp Val Asn Ser Phe Gln Glu Met Glu Ser Asp Lys Lys Phe Ala 
    290                 295                 300                 


Leu Thr Lys Thr Thr Thr Cys Val Asp Gln Gly Asp Ser Ser Gly Asn 
305                 310                 315                 320 


Arg Tyr Leu Pro Gly Phe Pro Met Lys Ile Asp Ile Pro Ser Leu Met 
                325                 330                 335     


Tyr Met Glu Pro Asn Val Arg Tyr Ser Ala Thr Lys Thr Ile Ser Leu 
            340                 345                 350         


Leu Phe Asn Ala Ile Pro Ala Ser Leu Gly Met Lys Leu Arg Gly Leu 
        355                 360                 365             


Leu Asp Arg Lys Gly Ser Trp Lys Lys Leu Asp Asp Met Gln Asn Ile 
    370                 375                 380                 


Phe Trp Cys His Lys Thr Phe Thr Thr Lys Tyr Val Thr Glu His Trp 
385                 390                 395                 400 


Cys Glu Asp His Phe Phe Gly Tyr Gln Tyr Leu Asn Gly Val Asn Pro 
                405                 410                 415     


Val Met Leu His Cys Ile Ser Ser Leu Pro Ser Lys Leu Pro Val Thr 
            420                 425                 430         


Asn Asp Met Val Ala Pro Leu Leu Gly Gln Asp Thr Cys Leu Gln Thr 
        435                 440                 445             


Glu Leu Glu Arg Gly Asn Ile Phe Leu Ala Asp Tyr Trp Ile Leu Ala 
    450                 455                 460                 


Glu Ala Pro Thr His Cys Leu Asn Gly Arg Gln Gln Tyr Val Ala Ala 
465                 470                 475                 480 


Pro Leu Cys Leu Leu Trp Leu Ser Pro Gln Gly Ala Leu Val Pro Leu 
                485                 490                 495     


Ala Ile Gln Leu Ser Gln Thr Pro Gly Pro Asp Ser Pro Ile Phe Leu 
            500                 505                 510         


Pro Thr Asp Ser Glu Trp Asp Trp Leu Leu Ala Lys Thr Trp Val Arg 
        515                 520                 525             


Asn Ser Glu Phe Leu Val His Glu Asn Asn Thr His Phe Leu Cys Thr 
    530                 535                 540                 


His Leu Leu Cys Glu Ala Phe Ala Met Ala Thr Leu Arg Gln Leu Pro 
545                 550                 555                 560 


Leu Cys His Pro Ile Tyr Lys Leu Leu Leu Pro His Thr Arg Tyr Thr 
                565                 570                 575     


Leu Gln Val Asn Thr Ile Ala Arg Ala Thr Leu Leu Asn Pro Glu Gly 
            580                 585                 590         


Leu Val Asp Gln Val Thr Ser Ile Gly Arg Gln Gly Leu Ile Tyr Leu 
        595                 600                 605             


Met Ser Thr Gly Leu Ala His Phe Thr Tyr Thr Asn Phe Cys Leu Pro 
    610                 615                 620                 


Asp Ser Leu Arg Ala Arg Gly Val Leu Ala Ile Pro Asn Tyr His Tyr 
625                 630                 635                 640 


Arg Asp Asp Gly Leu Lys Ile Trp Ala Ala Ile Glu Ser Phe Val Ser 
                645                 650                 655     


Glu Ile Val Gly Tyr Tyr Tyr Pro Ser Asp Ala Ser Val Gln Gln Asp 
            660                 665                 670         


Ser Glu Leu Gln Ala Trp Thr Gly Glu Ile Phe Ala Gln Ala Phe Leu 
        675                 680                 685             


Gly Arg Glu Ser Ser Gly Phe Pro Ser Arg Leu Cys Thr Pro Gly Glu 
    690                 695                 700                 


Met Val Lys Phe Leu Thr Ala Ile Ile Phe Asn Cys Ser Ala Gln His 
705                 710                 715                 720 


Ala Ala Val Asn Ser Gly Gln His Asp Phe Gly Ala Trp Met Pro Asn 
                725                 730                 735     


Ala Pro Ser Ser Met Arg Gln Pro Pro Pro Gln Thr Lys Gly Thr Thr 
            740                 745                 750         


Thr Leu Lys Thr Tyr Leu Asp Thr Leu Pro Glu Val Asn Ile Ser Cys 
        755                 760                 765             


Asn Asn Leu Leu Leu Phe Trp Leu Val Ser Gln Glu Pro Lys Asp Gln 
    770                 775                 780                 


Arg Pro Leu Gly Thr Tyr Pro Asp Glu His Phe Thr Glu Glu Ala Pro 
785                 790                 795                 800 


Arg Arg Ser Ile Ala Ala Phe Gln Ser Arg Leu Ala Gln Ile Ser Arg 
                805                 810                 815     


Asp Ile Gln Glu Arg Asn Gln Gly Leu Ala Leu Pro Tyr Thr Tyr Leu 
            820                 825                 830         


Asp Pro Pro Leu Ile Glu Asn Ser Val Ser Ile 
        835                 840             


<210>  471
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALPI__Homo_sapiens__NP_001622

<400>  471

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Pro Ala Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu 
            500                 505                 510         


Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
        515                 520                 525             


<210>  472
<211>  1244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALPK1__Homo_sapiens__NP_001095876

<400>  472

Met Asn Asn Gln Lys Val Val Ala Val Leu Leu Gln Glu Cys Lys Gln 
1               5                   10                  15      


Val Leu Asp Gln Leu Leu Leu Glu Ala Pro Asp Val Ser Glu Glu Asp 
            20                  25                  30          


Lys Ser Glu Asp Gln Arg Cys Arg Ala Leu Leu Pro Ser Glu Leu Arg 
        35                  40                  45              


Thr Leu Ile Gln Glu Ala Lys Glu Met Lys Trp Pro Phe Val Pro Glu 
    50                  55                  60                  


Lys Trp Gln Tyr Lys Gln Ala Val Gly Pro Glu Asp Lys Thr Asn Leu 
65                  70                  75                  80  


Lys Asp Val Ile Gly Ala Gly Leu Gln Gln Leu Leu Ala Ser Leu Arg 
                85                  90                  95      


Ala Ser Ile Leu Ala Arg Asp Cys Ala Ala Ala Ala Ala Ile Val Phe 
            100                 105                 110         


Leu Val Asp Arg Phe Leu Tyr Gly Leu Asp Val Ser Gly Lys Leu Leu 
        115                 120                 125             


Gln Val Ala Lys Gly Leu His Lys Leu Gln Pro Ala Thr Pro Ile Ala 
    130                 135                 140                 


Pro Gln Val Val Ile Arg Gln Ala Arg Ile Ser Val Asn Ser Gly Lys 
145                 150                 155                 160 


Leu Leu Lys Ala Glu Tyr Ile Leu Ser Ser Leu Ile Ser Asn Asn Gly 
                165                 170                 175     


Ala Thr Gly Thr Trp Leu Tyr Arg Asn Glu Ser Asp Lys Val Leu Val 
            180                 185                 190         


Gln Ser Val Cys Ile Gln Ile Arg Gly Gln Ile Leu Gln Lys Leu Gly 
        195                 200                 205             


Met Trp Tyr Glu Ala Ala Glu Leu Ile Trp Ala Ser Ile Val Gly Tyr 
    210                 215                 220                 


Leu Ala Leu Pro Gln Pro Asp Lys Lys Gly Leu Ser Thr Ser Leu Gly 
225                 230                 235                 240 


Ile Leu Ala Asp Ile Phe Val Ser Met Ser Lys Asn Asp Tyr Glu Lys 
                245                 250                 255     


Phe Lys Asn Asn Pro Gln Ile Asn Leu Ser Leu Leu Lys Glu Phe Asp 
            260                 265                 270         


His His Leu Leu Ser Ala Ala Glu Ala Cys Lys Leu Ala Ala Ala Phe 
        275                 280                 285             


Ser Ala Tyr Thr Pro Leu Phe Val Leu Thr Ala Val Asn Ile Arg Gly 
    290                 295                 300                 


Thr Cys Leu Leu Ser Tyr Ser Ser Ser Asn Asp Cys Pro Pro Glu Leu 
305                 310                 315                 320 


Lys Asn Leu His Leu Cys Glu Ala Lys Glu Ala Phe Glu Ile Gly Leu 
                325                 330                 335     


Leu Thr Lys Arg Asp Asp Glu Pro Val Thr Gly Lys Gln Glu Leu His 
            340                 345                 350         


Ser Phe Val Lys Ala Ala Phe Gly Leu Thr Thr Val His Arg Arg Leu 
        355                 360                 365             


His Gly Glu Thr Gly Thr Val His Ala Ala Ser Gln Leu Cys Lys Glu 
    370                 375                 380                 


Ala Met Gly Lys Leu Tyr Asn Phe Ser Thr Ser Ser Arg Ser Gln Asp 
385                 390                 395                 400 


Arg Glu Ala Leu Ser Gln Glu Val Met Ser Val Ile Ala Gln Val Lys 
                405                 410                 415     


Glu His Leu Gln Val Gln Ser Phe Ser Asn Val Asp Asp Arg Ser Tyr 
            420                 425                 430         


Val Pro Glu Ser Phe Glu Cys Arg Leu Asp Lys Leu Ile Leu His Gly 
        435                 440                 445             


Gln Gly Asp Phe Gln Lys Ile Leu Asp Thr Tyr Ser Gln His His Thr 
    450                 455                 460                 


Ser Val Cys Glu Val Phe Glu Ser Asp Cys Gly Asn Asn Lys Asn Glu 
465                 470                 475                 480 


Gln Lys Asp Ala Lys Thr Gly Val Cys Ile Thr Ala Leu Lys Thr Glu 
                485                 490                 495     


Ile Lys Asn Ile Asp Thr Val Ser Thr Thr Gln Glu Lys Pro His Cys 
            500                 505                 510         


Gln Arg Asp Thr Gly Ile Ser Ser Ser Leu Met Gly Lys Asn Val Gln 
        515                 520                 525             


Arg Glu Leu Arg Arg Gly Gly Arg Arg Asn Trp Thr His Ser Asp Ala 
    530                 535                 540                 


Phe Arg Val Ser Leu Asp Gln Asp Val Glu Thr Glu Thr Glu Pro Ser 
545                 550                 555                 560 


Asp Tyr Ser Asn Gly Glu Gly Ala Val Phe Asn Lys Ser Leu Ser Gly 
                565                 570                 575     


Ser Gln Thr Ser Ser Ala Trp Ser Asn Leu Ser Gly Phe Ser Ser Ser 
            580                 585                 590         


Ala Ser Trp Glu Glu Val Asn Tyr His Val Asp Asp Arg Ser Ala Arg 
        595                 600                 605             


Lys Glu Pro Gly Lys Glu His Leu Val Asp Thr Gln Cys Ser Thr Ala 
    610                 615                 620                 


Leu Ser Glu Glu Leu Glu Asn Asp Arg Glu Gly Arg Ala Met His Ser 
625                 630                 635                 640 


Leu His Ser Gln Leu His Asp Leu Ser Leu Gln Glu Pro Asn Asn Asp 
                645                 650                 655     


Asn Leu Glu Pro Ser Gln Asn Gln Pro Gln Gln Gln Met Pro Leu Thr 
            660                 665                 670         


Pro Phe Ser Pro His Asn Thr Pro Gly Ile Phe Leu Ala Pro Gly Ala 
        675                 680                 685             


Gly Leu Leu Glu Gly Ala Pro Glu Gly Ile Gln Glu Val Arg Asn Met 
    690                 695                 700                 


Gly Pro Arg Asn Thr Ser Ala His Ser Arg Pro Ser Tyr Arg Ser Ala 
705                 710                 715                 720 


Ser Trp Ser Ser Asp Ser Gly Arg Pro Lys Asn Met Gly Thr His Pro 
                725                 730                 735     


Ser Val Gln Lys Glu Glu Ala Phe Glu Ile Ile Val Glu Phe Pro Glu 
            740                 745                 750         


Thr Asn Cys Asp Val Lys Asp Arg Gln Gly Lys Glu Gln Gly Glu Glu 
        755                 760                 765             


Ile Ser Glu Arg Gly Ala Gly Pro Thr Phe Lys Ala Ser Pro Ser Trp 
    770                 775                 780                 


Val Asp Pro Glu Gly Glu Thr Ala Glu Ser Thr Glu Asp Ala Pro Leu 
785                 790                 795                 800 


Asp Phe His Arg Val Leu His Asn Ser Leu Gly Asn Ile Ser Met Leu 
                805                 810                 815     


Pro Cys Ser Ser Phe Thr Pro Asn Trp Pro Val Gln Asn Pro Asp Ser 
            820                 825                 830         


Arg Lys Ser Gly Gly Pro Val Ala Glu Gln Gly Ile Asp Pro Asp Ala 
        835                 840                 845             


Ser Thr Val Asp Glu Glu Gly Gln Leu Leu Asp Ser Met Asp Val Pro 
    850                 855                 860                 


Cys Thr Asn Gly His Gly Ser His Arg Leu Cys Ile Leu Arg Gln Pro 
865                 870                 875                 880 


Pro Gly Gln Arg Ala Glu Thr Pro Asn Ser Ser Val Ser Gly Asn Ile 
                885                 890                 895     


Leu Phe Pro Val Leu Ser Glu Asp Cys Thr Thr Thr Glu Glu Gly Asn 
            900                 905                 910         


Gln Pro Gly Asn Met Leu Asn Cys Ser Gln Asn Ser Ser Ser Ser Ser 
        915                 920                 925             


Val Trp Trp Leu Lys Ser Pro Ala Phe Ser Ser Gly Ser Ser Glu Gly 
    930                 935                 940                 


Asp Ser Pro Trp Ser Tyr Leu Asn Ser Ser Gly Ser Ser Trp Val Ser 
945                 950                 955                 960 


Leu Pro Gly Lys Met Arg Lys Glu Ile Leu Glu Ala Arg Thr Leu Gln 
                965                 970                 975     


Pro Asp Asp Phe Glu Lys Leu Leu Ala Gly Val Arg His Asp Trp Leu 
            980                 985                 990         


Phe Gln Arg Leu Glu Asn Thr Gly  Val Phe Lys Pro Ser  Gln Leu His 
        995                 1000                 1005             


Arg Ala  His Ser Ala Leu Leu  Leu Lys Tyr Ser Lys  Lys Ser Glu 
    1010                 1015                 1020             


Leu Trp  Thr Ala Gln Glu Thr  Ile Val Tyr Leu Gly  Asp Tyr Leu 
    1025                 1030                 1035             


Thr Val  Lys Lys Lys Gly Arg  Gln Arg Asn Ala Phe  Trp Val His 
    1040                 1045                 1050             


His Leu  His Gln Glu Glu Ile  Leu Gly Arg Tyr Val  Gly Lys Asp 
    1055                 1060                 1065             


Tyr Lys  Glu Gln Lys Gly Leu  Trp His His Phe Thr  Asp Val Glu 
    1070                 1075                 1080             


Arg Gln  Met Thr Ala Gln His  Tyr Val Thr Glu Phe  Asn Lys Arg 
    1085                 1090                 1095             


Leu Tyr  Glu Gln Asn Ile Pro  Thr Gln Ile Phe Tyr  Ile Pro Ser 
    1100                 1105                 1110             


Thr Ile  Leu Leu Ile Leu Glu  Asp Lys Thr Ile Lys  Gly Cys Ile 
    1115                 1120                 1125             


Ser Val  Glu Pro Tyr Ile Leu  Gly Glu Phe Val Lys  Leu Ser Asn 
    1130                 1135                 1140             


Asn Thr  Lys Val Val Lys Thr  Glu Tyr Lys Ala Thr  Glu Tyr Gly 
    1145                 1150                 1155             


Leu Ala  Tyr Gly His Phe Ser  Tyr Glu Phe Ser Asn  His Arg Asp 
    1160                 1165                 1170             


Val Val  Val Asp Leu Gln Gly  Trp Val Thr Gly Asn  Gly Lys Gly 
    1175                 1180                 1185             


Leu Ile  Tyr Leu Thr Asp Pro  Gln Ile His Ser Val  Asp Gln Lys 
    1190                 1195                 1200             


Val Phe  Thr Thr Asn Phe Gly  Lys Arg Gly Ile Phe  Tyr Phe Phe 
    1205                 1210                 1215             


Asn Asn  Gln His Val Glu Cys  Asn Glu Ile Cys His  Arg Leu Ser 
    1220                 1225                 1230             


Leu Thr  Arg Pro Ser Met Glu  Lys Pro Cys Thr 
    1235                 1240                 


<210>  473
<211>  2170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALPK2__Homo_sapiens__NP_443179

<400>  473

Met Lys Asp Ser Glu Gly Pro Gln Arg Pro Pro Leu Cys Phe Leu Ser 
1               5                   10                  15      


Thr Leu Leu Ser Gln Lys Val Pro Glu Lys Ser Asp Ala Val Leu Arg 
            20                  25                  30          


Cys Ile Ile Ser Gly Gln Pro Lys Pro Glu Val Thr Trp Tyr Lys Asn 
        35                  40                  45              


Gly Gln Ala Ile Asp Gly Ser Gly Ile Ile Ser Asn Tyr Glu Phe Phe 
    50                  55                  60                  


Glu Asn Gln Tyr Ile His Val Leu His Leu Ser Cys Cys Thr Lys Asn 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Gln Ile Ser Ala Lys Asn Ser Phe Gly Met Ile 
                85                  90                  95      


Cys Cys Ser Ala Ser Val Glu Val Glu Cys Ser Ser Glu Asn Pro Gln 
            100                 105                 110         


Leu Ser Pro Asn Leu Glu Asp Asp Arg Asp Arg Gly Trp Lys His Glu 
        115                 120                 125             


Thr Gly Thr His Glu Glu Glu Arg Ala Asn Gln Ile Asp Glu Lys Glu 
    130                 135                 140                 


His Pro Tyr Lys Glu Glu Glu Ser Ile Ser Pro Gly Thr Pro Arg Ser 
145                 150                 155                 160 


Ala Asp Ser Ser Pro Ser Lys Ser Asn His Ser Leu Ser Leu Gln Ser 
                165                 170                 175     


Leu Gly Asn Leu Asp Ile Ser Val Ser Ser Ser Glu Asn Pro Leu Gly 
            180                 185                 190         


Val Lys Gly Thr Arg His Thr Gly Glu Ala Tyr Asp Pro Ser Asn Thr 
        195                 200                 205             


Glu Glu Ile Ala Asn Gly Leu Leu Phe Leu Asn Ser Ser His Ile Tyr 
    210                 215                 220                 


Glu Lys Gln Asp Arg Cys Cys His Lys Thr Val His Ser Met Ala Ser 
225                 230                 235                 240 


Lys Phe Thr Asp Gly Asp Leu Asn Asn Asp Gly Pro His Asp Glu Gly 
                245                 250                 255     


Leu Arg Ser Ser Gln Gln Asn Pro Lys Val Gln Lys Tyr Ile Ser Phe 
            260                 265                 270         


Ser Leu Pro Leu Ser Glu Ala Thr Ala His Ile Tyr Pro Gly Asp Ser 
        275                 280                 285             


Ala Val Ala Asn Lys Gln Pro Ser Pro Gln Leu Ser Ser Glu Asp Ser 
    290                 295                 300                 


Asp Ser Asp Tyr Glu Leu Cys Pro Glu Ile Thr Leu Thr Tyr Thr Glu 
305                 310                 315                 320 


Glu Phe Ser Asp Asp Asp Leu Glu Tyr Leu Glu Cys Ser Asp Val Met 
                325                 330                 335     


Thr Asp Tyr Ser Asn Ala Val Trp Gln Arg Asn Leu Leu Gly Thr Glu 
            340                 345                 350         


His Val Phe Leu Leu Glu Ser Asp Asp Glu Glu Met Glu Phe Gly Glu 
        355                 360                 365             


His Cys Leu Gly Gly Cys Glu His Phe Leu Ser Gly Met Gly Cys Gly 
    370                 375                 380                 


Ser Arg Val Ser Gly Asp Ala Gly Pro Met Val Ala Thr Ala Gly Phe 
385                 390                 395                 400 


Cys Gly His His Ser Gln Pro Gln Glu Val Gly Val Arg Ser Ser Arg 
                405                 410                 415     


Val Ser Lys His Gly Pro Ser Ser Pro Gln Thr Gly Met Thr Leu Ile 
            420                 425                 430         


Leu Gly Pro His Gln Asp Gly Thr Ser Ser Val Thr Glu Gln Gly Arg 
        435                 440                 445             


Tyr Lys Leu Pro Thr Ala Pro Glu Ala Ala Glu Asn Asp Tyr Pro Gly 
    450                 455                 460                 


Ile Gln Gly Glu Thr Arg Asp Ser His Gln Ala Arg Glu Glu Phe Ala 
465                 470                 475                 480 


Ser Asp Asn Leu Leu Asn Met Asp Glu Ser Val Arg Glu Thr Glu Met 
                485                 490                 495     


Lys Leu Leu Ser Gly Glu Ser Glu Asn Ser Gly Met Ser Gln Cys Trp 
            500                 505                 510         


Glu Thr Ala Ala Asp Lys Arg Val Gly Gly Lys Asp Leu Trp Ser Lys 
        515                 520                 525             


Arg Gly Ser Arg Lys Ser Ala Arg Val Arg Gln Pro Gly Met Lys Gly 
    530                 535                 540                 


Asn Pro Lys Lys Pro Asn Ala Asn Leu Arg Glu Ser Thr Thr Glu Gly 
545                 550                 555                 560 


Thr Leu His Leu Cys Ser Ala Lys Glu Ser Ala Glu Pro Pro Leu Thr 
                565                 570                 575     


Gln Ser Asp Lys Arg Glu Thr Ser His Thr Thr Ala Ala Ala Thr Gly 
            580                 585                 590         


Arg Ser Ser His Ala Asp Ala Arg Glu Cys Ala Ile Ser Thr Gln Ala 
        595                 600                 605             


Glu Gln Glu Ala Lys Thr Leu Gln Thr Ser Thr Asp Ser Val Ser Lys 
    610                 615                 620                 


Glu Gly Asn Thr Asn Cys Lys Gly Glu Gly Met Gln Val Asn Thr Leu 
625                 630                 635                 640 


Phe Glu Thr Ser Gln Val Pro Asp Trp Ser Asp Pro Pro Gln Val Gln 
                645                 650                 655     


Val Gln Glu Thr Val Arg Glu Thr Ile Ser Cys Ser Gln Met Pro Ala 
            660                 665                 670         


Phe Ser Glu Pro Ala Gly Glu Glu Ser Pro Phe Thr Gly Thr Thr Thr 
        675                 680                 685             


Ile Ser Phe Ser Asn Leu Gly Gly Val His Lys Glu Asn Ala Ser Leu 
    690                 695                 700                 


Ala Gln His Ser Glu Val Lys Pro Cys Thr Cys Gly Pro Gln His Glu 
705                 710                 715                 720 


Glu Lys Gln Asp Arg Asp Gly Asn Ile Pro Asp Asn Phe Arg Glu Asp 
                725                 730                 735     


Leu Lys Tyr Glu Gln Ser Ile Ser Glu Ala Asn Asp Glu Thr Met Ser 
            740                 745                 750         


Pro Gly Val Phe Ser Arg His Leu Pro Lys Asp Ala Arg Ala Asp Phe 
        755                 760                 765             


Arg Glu Pro Val Ala Val Ser Val Ala Ser Pro Glu Pro Thr Asp Thr 
    770                 775                 780                 


Ala Leu Thr Leu Glu Asn Val Cys Asp Glu Pro Arg Asp Arg Glu Ala 
785                 790                 795                 800 


Val Cys Ala Met Glu Cys Phe Glu Ala Gly Asp Gln Gly Thr Cys Phe 
                805                 810                 815     


Asp Thr Ile Asp Ser Leu Val Gly Arg Pro Val Asp Lys Tyr Ser Pro 
            820                 825                 830         


Gln Glu Ile Cys Ser Val Asp Thr Glu Leu Ala Glu Gly Gln Asn Lys 
        835                 840                 845             


Val Ser Asp Leu Cys Ser Ser Asn Asp Lys Thr Leu Glu Val Phe Phe 
    850                 855                 860                 


Gln Thr Gln Val Ser Glu Thr Ser Val Ser Thr Cys Lys Ser Ser Lys 
865                 870                 875                 880 


Asp Gly Asn Ser Val Met Ser Pro Leu Phe Thr Ser Thr Phe Thr Leu 
                885                 890                 895     


Asn Ile Ser His Thr Ala Ser Glu Gly Ala Thr Gly Glu Asn Leu Ala 
            900                 905                 910         


Lys Val Glu Asn Ser Thr Tyr Pro Leu Ala Ser Thr Val His Ala Gly 
        915                 920                 925             


Gln Glu Gln Pro Ser Pro Ser Asn Ser Gly Gly Leu Asp Glu Thr Gln 
    930                 935                 940                 


Leu Leu Ser Ser Glu Asn Asn Pro Leu Val Gln Phe Lys Glu Gly Gly 
945                 950                 955                 960 


Asp Lys Ser Pro Ser Pro Ser Ala Ala Asp Thr Thr Ala Thr Pro Ala 
                965                 970                 975     


Ser Tyr Ser Ser Ile Val Ser Phe Pro Trp Glu Lys Pro Thr Thr Leu 
            980                 985                 990         


Thr Ala Asn Asn Glu Cys Phe Gln  Ala Thr Arg Glu Thr  Glu Asp Thr 
        995                 1000                 1005             


Ser Thr  Val Thr Ile Ala Thr  Glu Val His Pro Ala  Lys Tyr Leu 
    1010                 1015                 1020             


Ala Val  Ser Ile Pro Glu Asp  Lys His Ala Gly Gly  Thr Glu Glu 
    1025                 1030                 1035             


Arg Phe  Pro Arg Ala Ser His  Glu Lys Val Ser Gln  Phe Pro Ser 
    1040                 1045                 1050             


Gln Val  Gln Leu Asp His Ile  Leu Ser Gly Ala Thr  Ile Lys Ser 
    1055                 1060                 1065             


Thr Lys  Glu Leu Leu Cys Arg  Ala Pro Ser Val Pro  Gly Val Pro 
    1070                 1075                 1080             


His His  Val Leu Gln Leu Pro  Glu Gly Glu Gly Phe  Cys Ser Asn 
    1085                 1090                 1095             


Ser Pro  Leu Gln Val Asp Asn  Leu Ser Gly Asp Lys  Ser Gln Thr 
    1100                 1105                 1110             


Val Asp  Arg Ala Asp Phe Arg  Ser Tyr Glu Glu Asn  Phe Gln Glu 
    1115                 1120                 1125             


Arg Gly  Ser Glu Thr Lys Gln  Gly Val Gln Gln Gln  Ser Leu Ser 
    1130                 1135                 1140             


Gln Gln  Gly Ser Leu Ser Ala  Pro Asp Phe Gln Gln  Ser Leu Pro 
    1145                 1150                 1155             


Thr Thr  Ser Ala Ala Gln Glu  Glu Arg Asn Leu Val  Pro Thr Ala 
    1160                 1165                 1170             


His Ser  Pro Ala Ser Ser Arg  Glu Gly Ala Gly Gln  Arg Ser Gly 
    1175                 1180                 1185             


Trp Gly  Thr Arg Val Ser Val  Val Ala Glu Thr Ala  Gly Glu Glu 
    1190                 1195                 1200             


Asp Ser  Gln Ala Leu Ser Asn  Val Pro Ser Leu Ser  Asp Ile Leu 
    1205                 1210                 1215             


Leu Glu  Glu Ser Lys Glu Tyr  Arg Pro Gly Asn Trp  Glu Ala Gly 
    1220                 1225                 1230             


Asn Lys  Leu Lys Ile Ile Thr  Leu Glu Ala Ser Ala  Ser Glu Ile 
    1235                 1240                 1245             


Trp Pro  Pro Arg Gln Leu Thr  Asn Ser Glu Ser Lys  Ala Ser Asp 
    1250                 1255                 1260             


Gly Gly  Leu Ile Ile Pro Asp  Lys Val Trp Ala Val  Pro Asp Ser 
    1265                 1270                 1275             


Leu Lys  Ala Asp Ala Val Val  Pro Glu Leu Ala Pro  Ser Glu Ile 
    1280                 1285                 1290             


Ala Ala  Leu Ala His Ser Pro  Glu Asp Ala Glu Ser  Ala Leu Ala 
    1295                 1300                 1305             


Asp Ser  Arg Glu Ser His Lys  Gly Glu Glu Pro Thr  Ile Ser Val 
    1310                 1315                 1320             


His Trp  Arg Ser Leu Ser Ser  Arg Gly Phe Ser Gln  Pro Arg Leu 
    1325                 1330                 1335             


Leu Glu  Ser Ser Val Asp Pro  Val Asp Glu Lys Glu  Leu Ser Val 
    1340                 1345                 1350             


Thr Asp  Ser Leu Ser Ala Ala  Ser Glu Thr Gly Gly  Lys Glu Asn 
    1355                 1360                 1365             


Val Asn  Asn Val Ser Gln Asp  Gln Glu Glu Lys Gln  Leu Lys Met 
    1370                 1375                 1380             


Asp His  Thr Ala Phe Phe Lys  Lys Phe Leu Thr Cys  Pro Lys Ile 
    1385                 1390                 1395             


Leu Glu  Ser Ser Val Asp Pro  Ile Asp Glu Ile Ser  Val Ile Glu 
    1400                 1405                 1410             


Tyr Thr  Arg Ala Gly Lys Pro  Glu Pro Ser Glu Thr  Thr Pro Gln 
    1415                 1420                 1425             


Gly Ala  Arg Glu Gly Gly Gln  Ser Asn Asp Gly Asn  Met Gly His 
    1430                 1435                 1440             


Glu Ala  Glu Ile Gln Pro Ala  Ile Leu Gln Val Pro  Cys Leu Gln 
    1445                 1450                 1455             


Gly Thr  Ile Leu Ser Glu Asn  Arg Ile Ser Arg Ser  Gln Glu Gly 
    1460                 1465                 1470             


Ser Met  Lys Gln Glu Ala Glu  Gln Ile Gln Pro Glu  Glu Ala Lys 
    1475                 1480                 1485             


Thr Ala  Ile Trp Gln Val Leu  Gln Pro Ser Glu Gly  Gly Glu Arg 
    1490                 1495                 1500             


Ile Pro  Ser Gly Cys Ser Ile  Gly Gln Ile Gln Glu  Ser Ser Asp 
    1505                 1510                 1515             


Gly Ser  Leu Gly Glu Ala Glu  Gln Ser Lys Lys Asp  Lys Ala Glu 
    1520                 1525                 1530             


Leu Ile  Ser Pro Thr Ser Pro  Leu Ser Ser Cys Leu  Pro Ile Met 
    1535                 1540                 1545             


Thr His  Ala Ser Leu Gly Val  Asp Thr His Asn Ser  Thr Gly Gln 
    1550                 1555                 1560             


Ile His  Asp Val Pro Glu Asn  Asp Ile Val Glu Pro  Arg Lys Arg 
    1565                 1570                 1575             


Gln Tyr  Val Phe Pro Val Ser  Gln Lys Arg Gly Thr  Ile Glu Asn 
    1580                 1585                 1590             


Glu Arg  Gly Lys Pro Leu Pro  Ser Ser Pro Asp Leu  Thr Arg Phe 
    1595                 1600                 1605             


Pro Cys  Thr Ser Ser Pro Glu  Gly Asn Val Thr Asp  Phe Leu Ile 
    1610                 1615                 1620             


Ser His  Lys Met Glu Glu Pro  Lys Ile Glu Val Leu  Gln Ile Gly 
    1625                 1630                 1635             


Glu Thr  Lys Pro Pro Ser Ser  Ser Ser Ser Ser Ala  Lys Thr Leu 
    1640                 1645                 1650             


Ala Phe  Ile Ser Gly Glu Arg  Glu Leu Glu Lys Ala  Pro Lys Leu 
    1655                 1660                 1665             


Leu Gln  Asp Pro Cys Gln Lys  Gly Thr Leu Gly Cys  Ala Lys Lys 
    1670                 1675                 1680             


Ser Arg  Glu Arg Glu Lys Ser  Leu Glu Ala Arg Ala  Gly Lys Ser 
    1685                 1690                 1695             


Pro Gly  Thr Leu Thr Ala Val  Thr Gly Ser Glu Glu  Val Lys Arg 
    1700                 1705                 1710             


Lys Pro  Glu Ala Pro Gly Ser  Gly His Leu Ala Glu  Gly Val Lys 
    1715                 1720                 1725             


Lys Lys  Ile Leu Ser Arg Val  Ala Ala Leu Arg Leu  Lys Leu Glu 
    1730                 1735                 1740             


Glu Lys  Glu Asn Ile Arg Lys  Asn Ser Ala Phe Leu  Lys Lys Met 
    1745                 1750                 1755             


Pro Lys  Leu Glu Thr Ser Leu  Ser His Thr Glu Glu  Lys Gln Asp 
    1760                 1765                 1770             


Pro Lys  Lys Pro Ser Cys Lys  Arg Glu Gly Arg Ala  Pro Val Leu 
    1775                 1780                 1785             


Leu Lys  Lys Ile Gln Ala Glu  Met Phe Pro Glu His  Ser Gly Asn 
    1790                 1795                 1800             


Val Lys  Leu Ser Cys Gln Phe  Ala Glu Ile His Glu  Asp Ser Thr 
    1805                 1810                 1815             


Ile Cys  Trp Thr Lys Asp Ser  Lys Ser Ile Ala Gln  Val Gln Arg 
    1820                 1825                 1830             


Ser Ala  Gly Asp Asn Ser Thr  Val Ser Phe Ala Ile  Val Gln Ala 
    1835                 1840                 1845             


Ser Pro  Lys Asp Gln Gly Leu  Tyr Tyr Cys Cys Ile  Lys Asn Ser 
    1850                 1855                 1860             


Tyr Gly  Lys Val Thr Ala Glu  Phe Asn Leu Thr Ala  Glu Val Leu 
    1865                 1870                 1875             


Lys Gln  Leu Ser Ser Arg Gln  Asp Thr Lys Gly Cys  Glu Glu Ile 
    1880                 1885                 1890             


Glu Phe  Ser Gln Leu Ile Phe  Lys Glu Asp Phe Leu  His Asp Ser 
    1895                 1900                 1905             


Tyr Phe  Gly Gly Arg Leu Arg  Gly Gln Ile Ala Thr  Glu Glu Leu 
    1910                 1915                 1920             


His Phe  Gly Glu Gly Val His  Arg Lys Ala Phe Arg  Ser Thr Val 
    1925                 1930                 1935             


Met His  Gly Leu Met Pro Val  Phe Lys Pro Gly His  Ala Cys Val 
    1940                 1945                 1950             


Leu Lys  Val His Asn Ala Ile  Ala Tyr Gly Thr Arg  Asn Asn Asp 
    1955                 1960                 1965             


Glu Leu  Ile Gln Arg Asn Tyr  Lys Leu Ala Ala Gln  Glu Cys Tyr 
    1970                 1975                 1980             


Val Gln  Asn Thr Ala Arg Tyr  Tyr Ala Lys Ile Tyr  Ala Ala Glu 
    1985                 1990                 1995             


Ala Gln  Pro Leu Glu Gly Phe  Gly Glu Val Pro Glu  Ile Ile Pro 
    2000                 2005                 2010             


Ile Phe  Leu Ile His Arg Pro  Glu Asn Asn Ile Pro  Tyr Ala Thr 
    2015                 2020                 2025             


Val Glu  Glu Glu Leu Ile Gly  Glu Phe Val Lys Tyr  Ser Ile Arg 
    2030                 2035                 2040             


Asp Gly  Lys Glu Ile Asn Phe  Leu Arg Arg Glu Ser  Glu Ala Gly 
    2045                 2050                 2055             


Gln Lys  Cys Cys Thr Phe Gln  His Trp Val Tyr Gln  Lys Thr Ser 
    2060                 2065                 2070             


Gly Cys  Leu Leu Val Thr Asp  Met Gln Gly Val Gly  Met Lys Leu 
    2075                 2080                 2085             


Thr Asp  Val Gly Ile Ala Thr  Leu Ala Lys Gly Tyr  Lys Gly Phe 
    2090                 2095                 2100             


Lys Gly  Asn Cys Ser Met Thr  Phe Ile Asp Gln Phe  Lys Ala Leu 
    2105                 2110                 2115             


His Gln  Cys Asn Lys Tyr Cys  Lys Met Leu Gly Leu  Lys Ser Leu 
    2120                 2125                 2130             


Gln Asn  Asn Asn Gln Lys Gln  Lys Gln Pro Ser Ile  Gly Lys Ser 
    2135                 2140                 2145             


Lys Val  Gln Thr Asn Ser Met  Thr Ile Lys Lys Ala  Gly Pro Glu 
    2150                 2155                 2160             


Thr Pro  Gly Glu Lys Lys Thr  
    2165                 2170 


<210>  474
<211>  1907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALPK3__Homo_sapiens__NP_065829

<400>  474

Met Glu Val Ala Trp Leu Val Tyr Val Leu Gly Gln Gln Pro Leu Ala 
1               5                   10                  15      


Arg Gln Gly Glu Gly Gln Ser Arg Leu Val Pro Gly Arg Gly Leu Val 
            20                  25                  30          


Leu Trp Leu Pro Gly Leu Pro Arg Ser Ser Pro Ser Trp Pro Ala Val 
        35                  40                  45              


Asp Leu Ala Pro Leu Ala Pro Ala Arg Pro Arg Gly Pro Leu Ile Cys 
    50                  55                  60                  


His Thr Gly His Glu Gln Ala Gly Arg Glu Pro Gly Pro Gly Ser Ser 
65                  70                  75                  80  


Thr Lys Gly Pro Val Leu His Asp Gln Asp Thr Arg Cys Ala Phe Leu 
                85                  90                  95      


Pro Arg Pro Pro Gly Pro Leu Gln Thr Arg Arg Tyr Cys Arg His Gln 
            100                 105                 110         


Gly Arg Gln Gly Ser Gly Leu Gly Ala Gly Pro Gly Ala Gly Thr Trp 
        115                 120                 125             


Ala Pro Ala Pro Pro Gly Val Ser Lys Pro Arg Cys Pro Gly Arg Ala 
    130                 135                 140                 


Arg Pro Gly Glu Gly Gln Gln Gln Val Thr Thr Ala Arg Pro Pro Ala 
145                 150                 155                 160 


Ile Asn Arg Gly Ala Arg Gln Pro Arg Ala Gly Ala Ala Ala Ala Gly 
                165                 170                 175     


Arg Gly Pro Gly Ala Gly Ala Trp Arg Thr Gly Glu Ala Ala Ala Ser 
            180                 185                 190         


Ala Gly Pro Ala Val Gly Glu Gly Gly Ala Met Gly Ser Arg Arg Ala 
        195                 200                 205             


Pro Ser Arg Gly Trp Gly Ala Gly Gly Arg Ser Gly Ala Gly Gly Asp 
    210                 215                 220                 


Gly Glu Asp Asp Gly Pro Val Trp Ile Pro Ser Pro Ala Ser Arg Ser 
225                 230                 235                 240 


Tyr Leu Leu Ser Val Arg Pro Glu Thr Ser Leu Ser Ser Asn Arg Leu 
                245                 250                 255     


Ser His Pro Ser Ser Gly Arg Ser Thr Phe Cys Ser Ile Ile Ala Gln 
            260                 265                 270         


Leu Thr Glu Glu Thr Gln Pro Leu Phe Glu Thr Thr Leu Lys Ser Arg 
        275                 280                 285             


Ser Val Ser Glu Asp Ser Asp Val Arg Phe Thr Cys Ile Val Thr Gly 
    290                 295                 300                 


Tyr Pro Glu Pro Glu Val Thr Trp Tyr Lys Asp Asp Thr Glu Leu Asp 
305                 310                 315                 320 


Arg Tyr Cys Gly Leu Pro Lys Tyr Glu Ile Thr His Gln Gly Asn Arg 
                325                 330                 335     


His Thr Leu Gln Leu Tyr Arg Cys Arg Glu Glu Asp Ala Ala Ile Tyr 
            340                 345                 350         


Gln Ala Ser Ala Gln Asn Ser Lys Gly Ile Val Ser Cys Ser Gly Val 
        355                 360                 365             


Leu Glu Val Gly Thr Met Thr Glu Tyr Lys Ile His Gln Arg Trp Phe 
    370                 375                 380                 


Ala Lys Leu Lys Arg Lys Ala Ala Ala Lys Leu Arg Glu Ile Glu Gln 
385                 390                 395                 400 


Ser Trp Lys His Glu Lys Ala Val Pro Gly Glu Val Asp Thr Leu Arg 
                405                 410                 415     


Lys Leu Ser Pro Asp Arg Phe Gln Arg Lys Arg Arg Leu Ser Gly Ala 
            420                 425                 430         


Gln Ala Pro Gly Pro Ser Val Pro Thr Arg Glu Pro Glu Gly Gly Thr 
        435                 440                 445             


Leu Ala Ala Trp Gln Glu Gly Glu Thr Glu Thr Ala Gln His Ser Gly 
    450                 455                 460                 


Leu Gly Leu Ile Asn Ser Phe Ala Ser Gly Glu Val Thr Thr Asn Gly 
465                 470                 475                 480 


Glu Ala Ala Pro Glu Asn Gly Glu Asp Gly Glu His Gly Leu Leu Thr 
                485                 490                 495     


Tyr Ile Cys Asp Ala Met Glu Leu Gly Pro Gln Arg Ala Leu Lys Glu 
            500                 505                 510         


Glu Ser Gly Ala Lys Lys Lys Lys Lys Asp Glu Glu Ser Lys Gln Gly 
        515                 520                 525             


Leu Arg Lys Pro Glu Leu Glu Lys Ala Ala Gln Ser Arg Arg Ser Ser 
    530                 535                 540                 


Glu Asn Cys Ile Pro Ser Ser Asp Glu Pro Asp Ser Cys Gly Thr Gln 
545                 550                 555                 560 


Gly Pro Val Gly Val Glu Gln Val Gln Thr Gln Pro Arg Gly Arg Ala 
                565                 570                 575     


Ala Arg Gly Pro Gly Ser Ser Gly Thr Asp Ser Thr Arg Lys Pro Ala 
            580                 585                 590         


Ser Ala Val Gly Thr Pro Asp Lys Ala Gln Lys Ala Pro Gly Pro Gly 
        595                 600                 605             


Pro Gly Gln Glu Val Tyr Phe Ser Leu Lys Asp Met Tyr Leu Glu Asn 
    610                 615                 620                 


Thr Gln Ala Val Arg Pro Leu Gly Glu Glu Gly Pro Gln Thr Leu Ser 
625                 630                 635                 640 


Val Arg Ala Pro Gly Glu Ser Pro Lys Gly Lys Ala Pro Leu Arg Ala 
                645                 650                 655     


Arg Ser Glu Gly Val Pro Gly Ala Pro Gly Gln Pro Thr His Ser Leu 
            660                 665                 670         


Thr Pro Gln Pro Thr Arg Pro Phe Asn Arg Lys Arg Phe Ala Pro Pro 
        675                 680                 685             


Lys Pro Lys Gly Glu Ala Thr Thr Asp Ser Lys Pro Ile Ser Ser Leu 
    690                 695                 700                 


Ser Gln Ala Pro Glu Cys Gly Ala Gln Ser Leu Gly Lys Ala Pro Pro 
705                 710                 715                 720 


Gln Ala Ser Val Gln Val Pro Thr Pro Pro Ala Arg Arg Arg His Gly 
                725                 730                 735     


Thr Arg Asp Ser Thr Leu Gln Gly Gln Ala Gly His Arg Thr Pro Gly 
            740                 745                 750         


Glu Val Leu Glu Cys Gln Thr Thr Thr Ala Pro Thr Met Ser Ala Ser 
        755                 760                 765             


Ser Ser Ser Asp Val Ala Ser Ile Gly Val Ser Thr Ser Gly Ser Gln 
    770                 775                 780                 


Gly Ile Ile Glu Pro Met Asp Met Glu Thr Gln Glu Asp Gly Arg Thr 
785                 790                 795                 800 


Ser Ala Asn Gln Arg Thr Gly Ser Lys Lys Asn Val Gln Ala Asp Gly 
                805                 810                 815     


Lys Ile Gln Val Asp Gly Arg Thr Arg Gly Asp Gly Thr Gln Thr Ala 
            820                 825                 830         


Gln Arg Thr Arg Ala Asp Arg Lys Thr Gln Val Asp Ala Gly Thr Gln 
        835                 840                 845             


Glu Ser Lys Arg Pro Gln Ser Asp Arg Ser Ala Gln Lys Gly Met Met 
    850                 855                 860                 


Thr Gln Gly Arg Ala Glu Thr Gln Leu Glu Thr Thr Gln Ala Gly Glu 
865                 870                 875                 880 


Lys Ile Gln Glu Asp Arg Lys Ala Gln Ala Asp Lys Gly Thr Gln Glu 
                885                 890                 895     


Asp Arg Arg Met Gln Gly Glu Lys Gly Met Gln Gly Glu Lys Gly Thr 
            900                 905                 910         


Gln Ser Glu Gly Ser Ala Pro Thr Ala Met Glu Gly Gln Ser Glu Gln 
        915                 920                 925             


Glu Val Ala Thr Ser Leu Gly Pro Pro Ser Arg Thr Pro Lys Leu Pro 
    930                 935                 940                 


Pro Thr Ala Gly Pro Arg Ala Pro Leu Asn Ile Glu Cys Phe Val Gln 
945                 950                 955                 960 


Thr Pro Glu Gly Ser Cys Phe Pro Lys Lys Pro Gly Cys Leu Pro Arg 
                965                 970                 975     


Ser Glu Glu Ala Val Val Thr Ala Ser Arg Asn His Glu Gln Thr Val 
            980                 985                 990         


Leu Gly Pro Leu Ser Gly Asn Leu  Met Leu Pro Ala Gln  Pro Pro His 
        995                 1000                 1005             


Glu Gly  Ser Val Glu Gln Val  Gly Gly Glu Arg Cys  Arg Gly Pro 
    1010                 1015                 1020             


Gln Ser  Ser Gly Pro Val Glu  Ala Lys Gln Glu Asp  Ser Pro Phe 
    1025                 1030                 1035             


Gln Cys  Pro Lys Glu Glu Arg  Pro Gly Gly Val Pro  Cys Met Asp 
    1040                 1045                 1050             


Gln Gly  Gly Cys Pro Leu Ala  Gly Leu Ser Gln Glu  Val Pro Thr 
    1055                 1060                 1065             


Met Pro  Ser Leu Pro Gly Thr  Gly Leu Thr Ala Ser  Pro Lys Ala 
    1070                 1075                 1080             


Gly Pro  Cys Ser Thr Pro Thr  Ser Gln His Gly Ser  Thr Ala Thr 
    1085                 1090                 1095             


Phe Leu  Pro Ser Glu Asp Gln  Val Leu Met Ser Ser  Ala Pro Thr 
    1100                 1105                 1110             


Leu His  Leu Gly Leu Gly Thr  Pro Thr Gln Ser His  Pro Pro Glu 
    1115                 1120                 1125             


Thr Met  Ala Thr Ser Ser Glu  Gly Ala Cys Ala Gln  Val Pro Asp 
    1130                 1135                 1140             


Val Glu  Gly Arg Thr Pro Gly  Pro Arg Ser Cys Asp  Pro Gly Leu 
    1145                 1150                 1155             


Ile Asp  Ser Leu Lys Asn Tyr  Leu Leu Leu Leu Leu  Lys Leu Ser 
    1160                 1165                 1170             


Ser Thr  Glu Thr Ser Gly Ala  Gly Gly Glu Ser Gln  Val Gly Ala 
    1175                 1180                 1185             


Ala Thr  Gly Gly Leu Val Pro  Ser Ala Thr Leu Thr  Pro Thr Val 
    1190                 1195                 1200             


Glu Val  Ala Gly Leu Ser Pro  Arg Thr Ser Arg Arg  Ile Leu Glu 
    1205                 1210                 1215             


Arg Val  Glu Asn Asn His Leu  Val Gln Ser Ala Gln  Thr Leu Leu 
    1220                 1225                 1230             


Leu Ser  Pro Cys Thr Ser Arg  Arg Leu Thr Gly Leu  Leu Asp Arg 
    1235                 1240                 1245             


Glu Val  Gln Ala Gly Arg Gln  Ala Leu Ala Ala Ala  Arg Gly Ser 
    1250                 1255                 1260             


Trp Gly  Pro Gly Pro Ser Ser  Leu Thr Val Pro Ala  Ile Val Val 
    1265                 1270                 1275             


Asp Glu  Glu Asp Pro Gly Leu  Ala Ser Glu Gly Ala  Ser Glu Gly 
    1280                 1285                 1290             


Glu Gly  Glu Val Ser Pro Glu  Gly Pro Gly Leu Leu  Gly Ala Ser 
    1295                 1300                 1305             


Gln Glu  Ser Ser Met Ala Gly  Arg Leu Gly Glu Ala  Gly Gly Gln 
    1310                 1315                 1320             


Ala Ala  Pro Gly Gln Gly Pro  Ser Ala Glu Ser Ile  Ala Gln Glu 
    1325                 1330                 1335             


Pro Ser  Gln Glu Glu Lys Phe  Pro Gly Glu Ala Leu  Thr Gly Leu 
    1340                 1345                 1350             


Pro Ala  Ala Thr Pro Glu Glu  Leu Ala Leu Gly Ala  Arg Arg Lys 
    1355                 1360                 1365             


Arg Phe  Leu Pro Lys Val Arg  Ala Ala Gly Asp Gly  Glu Ala Thr 
    1370                 1375                 1380             


Thr Pro  Glu Glu Arg Glu Ser  Pro Thr Val Ser Pro  Arg Gly Pro 
    1385                 1390                 1395             


Arg Lys  Ser Leu Val Pro Gly  Ser Pro Gly Thr Pro  Gly Arg Glu 
    1400                 1405                 1410             


Arg Arg  Ser Pro Thr Gln Gly  Arg Lys Ala Ser Met  Leu Glu Val 
    1415                 1420                 1425             


Pro Arg  Ala Glu Glu Glu Leu  Ala Ala Gly Asp Leu  Gly Pro Ser 
    1430                 1435                 1440             


Pro Lys  Ala Gly Gly Leu Asp  Thr Glu Val Ala Leu  Asp Glu Gly 
    1445                 1450                 1455             


Lys Gln  Glu Thr Leu Ala Lys  Pro Arg Lys Ala Lys  Asp Leu Leu 
    1460                 1465                 1470             


Lys Ala  Pro Gln Val Ile Arg  Lys Ile Arg Val Glu  Gln Phe Pro 
    1475                 1480                 1485             


Asp Ala  Ser Gly Ser Leu Lys  Leu Trp Cys Gln Phe  Phe Asn Ile 
    1490                 1495                 1500             


Leu Ser  Asp Ser Val Leu Thr  Trp Ala Lys Asp Gln  Arg Pro Val 
    1505                 1510                 1515             


Gly Glu  Val Gly Arg Ser Ala  Gly Asp Glu Gly Pro  Ala Ala Leu 
    1520                 1525                 1530             


Ala Ile  Val Gln Ala Ser Pro  Val Asp Cys Gly Val  Tyr Arg Cys 
    1535                 1540                 1545             


Thr Ile  His Asn Glu His Gly  Ser Ala Ser Thr Asp  Phe Cys Leu 
    1550                 1555                 1560             


Ser Pro  Glu Val Leu Ser Gly  Phe Ile Ser Arg Glu  Glu Gly Glu 
    1565                 1570                 1575             


Val Gly  Glu Glu Ile Glu Met  Thr Pro Met Val Phe  Ala Lys Gly 
    1580                 1585                 1590             


Leu Ala  Asp Ser Gly Cys Trp  Gly Asp Lys Leu Phe  Gly Arg Leu 
    1595                 1600                 1605             


Val Ser  Glu Glu Leu Arg Gly  Gly Gly Tyr Gly Cys  Gly Leu Arg 
    1610                 1615                 1620             


Lys Ala  Ser Gln Ala Lys Val  Ile Tyr Gly Leu Glu  Pro Ile Phe 
    1625                 1630                 1635             


Glu Ser  Gly Arg Thr Cys Ile  Ile Lys Val Ser Ser  Leu Leu Val 
    1640                 1645                 1650             


Phe Gly  Pro Ser Ser Glu Thr  Ser Leu Val Gly Arg  Asn Tyr Asp 
    1655                 1660                 1665             


Val Thr  Ile Gln Gly Cys Lys  Ile Gln Asn Met Ser  Arg Glu Tyr 
    1670                 1675                 1680             


Cys Lys  Ile Phe Ala Ala Glu  Ala Arg Ala Ala Pro  Gly Phe Gly 
    1685                 1690                 1695             


Glu Val  Pro Glu Ile Ile Pro  Leu Tyr Leu Ile Tyr  Arg Pro Ala 
    1700                 1705                 1710             


Asn Asn  Ile Pro Tyr Ala Thr  Leu Glu Glu Asp Leu  Gly Lys Pro 
    1715                 1720                 1725             


Leu Glu  Ser Tyr Cys Ser Arg  Glu Trp Gly Cys Ala  Glu Ala Pro 
    1730                 1735                 1740             


Thr Ala  Ser Gly Ser Ser Glu  Ala Met Gln Lys Cys  Gln Thr Phe 
    1745                 1750                 1755             


Gln His  Trp Leu Tyr Gln Trp  Thr Asn Gly Ser Phe  Leu Val Thr 
    1760                 1765                 1770             


Asp Leu  Ala Gly Val Asp Trp  Lys Met Thr Asp Val  Gln Ile Ala 
    1775                 1780                 1785             


Thr Lys  Leu Arg Gly Tyr Gln  Gly Leu Lys Glu Ser  Cys Phe Pro 
    1790                 1795                 1800             


Ala Leu  Leu Asp Arg Phe Ala  Ser Ser His Gln Cys  Asn Ala Tyr 
    1805                 1810                 1815             


Cys Glu  Leu Leu Gly Leu Thr  Pro Leu Lys Gly Pro  Glu Ala Ala 
    1820                 1825                 1830             


His Pro  Gln Ala Lys Ala Lys  Gly Ser Lys Ser Pro  Ser Ala Gly 
    1835                 1840                 1845             


Arg Lys  Gly Ser Gln Leu Ser  Pro Gln Pro Gln Lys  Lys Gly Leu 
    1850                 1855                 1860             


Pro Ser  Pro Gln Gly Thr Arg  Lys Ser Ala Pro Ser  Ser Lys Ala 
    1865                 1870                 1875             


Thr Pro  Gln Ala Ser Glu Pro  Val Thr Thr Gln Leu  Leu Gly Gln 
    1880                 1885                 1890             


Pro Pro  Thr Gln Glu Glu Gly  Ser Lys Ala Gln Gly  Met Arg 
    1895                 1900                 1905         


<210>  475
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALPP__Homo_sapiens__NP_001623

<400>  475

Met Leu Gly Pro Cys Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg 
1               5                   10                  15      


Leu Gln Leu Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp 
            20                  25                  30          


Phe Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu 
        35                  40                  45              


Gln Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp 
    50                  55                  60                  


Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln 
65                  70                  75                  80  


Lys Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe 
                85                  90                  95      


Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro 
            100                 105                 110         


Asp Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn 
        115                 120                 125             


Phe Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn 
    130                 135                 140                 


Thr Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys 
145                 150                 155                 160 


Ala Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala 
                165                 170                 175     


Ser Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser 
            180                 185                 190         


Asp Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile 
        195                 200                 205             


Ala Thr Gln Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly 
    210                 215                 220                 


Gly Arg Lys Tyr Met Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro 
225                 230                 235                 240 


Asp Asp Tyr Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val 
                245                 250                 255     


Gln Glu Trp Leu Ala Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Met Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met 
        275                 280                 285             


Gly Leu Phe Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser 
    290                 295                 300                 


Thr Leu Asp Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu 
305                 310                 315                 320 


Leu Ser Arg Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg 
                325                 330                 335     


Ile Asp His Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu 
            340                 345                 350         


Thr Ile Met Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser 
        355                 360                 365             


Glu Glu Asp Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe 
    370                 375                 380                 


Ser Phe Gly Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala 
385                 390                 395                 400 


Pro Gly Lys Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr 
            420                 425                 430         


Glu Ser Glu Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Asp Glu Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg 
    450                 455                 460                 


Gly Pro Gln Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile 
465                 470                 475                 480 


Ala His Val Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys 
                485                 490                 495     


Asp Leu Ala Pro Pro Ala Gly Thr Thr Asp Ala Ala His Pro Gly Arg 
            500                 505                 510         


Ser Val Val Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu 
        515                 520                 525             


Leu Glu Thr Ala Thr Ala Pro 
    530                 535 


<210>  476
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALPPL2__Homo_sapiens__NP_112603

<400>  476

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Phe Leu Ala Met Asp Arg Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Ser Val Asp Lys His Val Pro Asp Ser Gly 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr 
225                 230                 235                 240 


Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Leu Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys 
385                 390                 395                 400 


Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Gly 
        435                 440                 445             


Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Arg Ala Gly Thr Thr Asp Ala Ala His Pro Gly Pro Ser Val Val 
            500                 505                 510         


Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Thr 
        515                 520                 525             


Ala Thr Ala Pro 
    530         


<210>  477
<211>  953
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS2CL__Homo_sapiens__NP_001177636

<400>  477

Met Cys Asn Pro Glu Glu Ala Ala Leu Leu Arg Leu Glu Glu Val Phe 
1               5                   10                  15      


Ser Ala Thr Leu Ala His Val Asn Ser Leu Val Leu Gln Pro Leu Leu 
            20                  25                  30          


Pro Ala Ala Pro Asp Pro Ser Asp Pro Trp Gly Arg Glu Cys Leu Arg 
        35                  40                  45              


Leu Leu Gln Gln Leu His Lys Ser Ser Gln Gln Leu Trp Glu Val Thr 
    50                  55                  60                  


Glu Glu Ser Leu His Ser Leu Gln Glu Arg Leu Arg Tyr Pro Asp Ser 
65                  70                  75                  80  


Thr Gly Leu Glu Ser Leu Leu Leu Leu Arg Gly Ala Asp Arg Val Leu 
                85                  90                  95      


Gln Ala His Ile Glu Tyr Ile Glu Ser Tyr Thr Ser Cys Met Val Val 
            100                 105                 110         


Gln Ala Phe Gln Lys Ala Ala Lys Arg Arg Ser Glu Tyr Trp Arg Gly 
        115                 120                 125             


Gln Arg Lys Ala Leu Arg Gln Leu Leu Ser Gly Val Ser Ser Glu Gly 
    130                 135                 140                 


Ser Val Gly Ala Ser Leu Gly Gln Ala Leu His Gln Pro Leu Ala His 
145                 150                 155                 160 


His Val Gln Gln Tyr Val Leu Leu Leu Leu Ser Leu Gly Asp Thr Ile 
                165                 170                 175     


Gly Glu His His Pro Thr Arg Glu Leu Val Val Asn Ala Val Thr Leu 
            180                 185                 190         


Phe Gly Asn Leu Gln Ser Phe Met Lys Gln Glu Leu Asp Gln Ala Val 
        195                 200                 205             


Ala Thr Gln Ala Leu Trp His Thr Leu Arg Gly Arg Leu Arg Asp Val 
    210                 215                 220                 


Leu Cys Thr Pro Ala His Arg Leu Leu Gln Asp Ser Gln Asp Val Pro 
225                 230                 235                 240 


Val Thr Val Ala Pro Leu Arg Ala Glu Arg Val Leu Leu Phe Asp Asp 
                245                 250                 255     


Ala Leu Val Leu Leu Gln Gly His Asn Val His Thr Phe Asp Leu Lys 
            260                 265                 270         


Leu Val Trp Val Asp Pro Gly Gln Asp Gly Cys Thr Phe His Leu Leu 
        275                 280                 285             


Thr Pro Glu Glu Glu Phe Ser Phe Cys Ala Lys Asp Ser Gln Gly Gln 
    290                 295                 300                 


Ala Val Trp Gln Trp Lys Val Thr Trp Ala Val His Gln Ala Leu His 
305                 310                 315                 320 


Gly Lys Lys Asp Phe Pro Val Leu Gly Ala Gly Leu Glu Pro Ser Gln 
                325                 330                 335     


Pro Pro Asp Cys Arg Cys Ala Glu Tyr Thr Phe Gln Ala Glu Gly Arg 
            340                 345                 350         


Leu Cys Gln Ala Thr Tyr Glu Gly Glu Trp Cys Arg Gly Arg Pro His 
        355                 360                 365             


Gly Lys Gly Thr Leu Lys Trp Pro Asp Gly Arg Asn His Val Gly Asn 
    370                 375                 380                 


Phe Cys Gln Gly Leu Glu His Gly Phe Gly Ile Arg Leu Leu Pro Gln 
385                 390                 395                 400 


Ala Ser Glu Asp Lys Phe Asp Cys Tyr Lys Cys His Trp Arg Glu Gly 
                405                 410                 415     


Ser Met Cys Gly Tyr Gly Ile Cys Glu Tyr Ser Thr Asp Glu Val Tyr 
            420                 425                 430         


Lys Gly Tyr Phe Gln Glu Gly Leu Arg His Gly Phe Gly Val Leu Glu 
        435                 440                 445             


Ser Gly Pro Gln Ala Pro Gln Pro Phe Arg Tyr Thr Gly His Trp Glu 
    450                 455                 460                 


Arg Gly Gln Arg Ser Gly Tyr Gly Ile Glu Glu Asp Gly Asp Arg Gly 
465                 470                 475                 480 


Glu Arg Tyr Ile Gly Met Trp Gln Ala Gly Gln Arg His Gly Pro Gly 
                485                 490                 495     


Val Met Val Thr Gln Ala Gly Val Cys Tyr Gln Gly Thr Phe Gln Ala 
            500                 505                 510         


Asp Lys Thr Val Gly Pro Gly Ile Leu Leu Ser Glu Asp Asp Ser Leu 
        515                 520                 525             


Tyr Glu Gly Thr Phe Thr Arg Asp Leu Thr Leu Met Gly Lys Gly Lys 
    530                 535                 540                 


Val Thr Phe Pro Asn Gly Phe Thr Leu Glu Gly Ser Phe Gly Ser Gly 
545                 550                 555                 560 


Ala Gly Arg Gly Leu His Thr Gln Gly Val Leu Asp Thr Ala Ala Leu 
                565                 570                 575     


Pro Pro Asp Pro Ser Ser Thr Cys Lys Arg Gln Leu Gly Val Gly Ala 
            580                 585                 590         


Phe Pro Val Glu Ser Arg Trp Gln Gly Val Tyr Ser Pro Phe Arg Asp 
        595                 600                 605             


Phe Val Cys Ala Gly Cys Pro Arg Asp Leu Gln Glu Ala Leu Leu Gly 
    610                 615                 620                 


Phe Asp Val Gln Ser Ser Arg Glu Leu Arg Arg Ser Gln Asp Tyr Leu 
625                 630                 635                 640 


Ser Cys Glu Arg Thr His Pro Glu Asp Ser Val Gly Ser Met Glu Asp 
                645                 650                 655     


Ile Leu Glu Glu Leu Leu Gln His Arg Glu Pro Lys Ala Leu Gln Leu 
            660                 665                 670         


Tyr Leu Arg Lys Ala Leu Ser Asn Ser Leu His Pro Leu Gly Lys Leu 
        675                 680                 685             


Leu Arg Thr Leu Met Leu Thr Phe Gln Ala Thr Tyr Ala Gly Val Gly 
    690                 695                 700                 


Ala Asn Lys His Leu Gln Glu Leu Ala Gln Glu Glu Val Lys Gln His 
705                 710                 715                 720 


Ala Gln Glu Leu Trp Ala Ala Tyr Arg Gly Leu Leu Arg Val Ala Leu 
                725                 730                 735     


Glu Arg Lys Gly Gln Ala Leu Glu Glu Asp Glu Asp Thr Glu Thr Arg 
            740                 745                 750         


Asp Leu Gln Val His Gly Leu Val Leu Pro Leu Met Leu Pro Ser Phe 
        755                 760                 765             


Tyr Ser Glu Leu Phe Thr Leu Tyr Leu Leu Leu His Glu Arg Glu Asp 
    770                 775                 780                 


Ser Phe Tyr Ser Gln Gly Ile Ala Asn Leu Ser Leu Phe Pro Asp Thr 
785                 790                 795                 800 


Gln Leu Leu Glu Phe Leu Asp Val Gln Lys His Leu Trp Pro Leu Lys 
                805                 810                 815     


Asp Leu Thr Leu Thr Ser Asn Gln Arg Tyr Ser Leu Val Arg Asp Lys 
            820                 825                 830         


Cys Phe Leu Ser Ala Thr Glu Cys Leu Gln Lys Ile Met Thr Thr Val 
        835                 840                 845             


Asp Pro Arg Glu Lys Leu Glu Val Leu Glu Arg Thr Tyr Gly Glu Ile 
    850                 855                 860                 


Glu Gly Thr Val Ser Arg Val Leu Gly Arg Glu Tyr Lys Leu Pro Met 
865                 870                 875                 880 


Asp Asp Leu Leu Pro Leu Leu Ile Tyr Val Val Ser Arg Ala Arg Ile 
                885                 890                 895     


Gln His Leu Gly Ala Glu Ile His Leu Ile Arg Asp Met Met Asp Pro 
            900                 905                 910         


Asn His Thr Gly Gly Leu Tyr Asp Phe Leu Leu Thr Ala Leu Glu Ser 
        915                 920                 925             


Cys Tyr Glu His Ile Gln Lys Glu Asp Met Arg Leu His Arg Leu Pro 
    930                 935                 940                 


Gly His Trp His Ser Arg Glu Leu Trp 
945                 950             


<210>  478
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS2CR12__Homo_sapiens__NP_001120863

<400>  478

Met Tyr Pro Asn Pro Leu Ile Tyr Cys Thr Cys Trp Asp Pro Trp Asn 
1               5                   10                  15      


Leu Gly Pro Arg Lys Leu Ile Lys Thr Pro Gln Leu Pro Arg Lys Asn 
            20                  25                  30          


Ser Thr Gly Ser Ser Lys Leu Thr Pro Leu Val Pro Ala Pro Lys Asn 
        35                  40                  45              


His Asn Tyr Leu Gln Pro Thr Lys Pro Val Val Ser Pro Lys Met Lys 
    50                  55                  60                  


Ile His Ser Ala Arg Gln Glu Glu Thr Asn Lys Ser Phe Tyr Glu Val 
65                  70                  75                  80  


Ile Asn Val Ser Pro Gly Tyr Gln Leu Val Arg Asn Arg Glu Gln Ile 
                85                  90                  95      


Ser Val Thr Leu Gly Asp Glu Met Phe Asp Arg Lys Lys Arg Trp Glu 
            100                 105                 110         


Ser Glu Ile Pro Asp Lys Gly Arg Phe Ser Arg Thr Asn Ile Ile Ser 
        115                 120                 125             


Asp Leu Glu Glu Gln Ile Ser Glu Leu Thr Ala Ile Ile Glu Gln Met 
    130                 135                 140                 


Asn Arg Asp His Gln Ser Ala Gln Lys Leu Leu Ser Ser Glu Met Asp 
145                 150                 155                 160 


Leu Arg Cys Ala Glu Met Lys Gln Asn Phe Glu Asn Lys Asn Arg Glu 
                165                 170                 175     


Leu Lys Glu Ala His Glu Ala Glu Leu Ser Glu Leu Glu Asn Asn Tyr 
            180                 185                 190         


Lys Ala Ala Leu Lys Ala Glu Lys Leu Ala Ala Gln Glu Lys Leu Glu 
        195                 200                 205             


Glu Met Gly Lys Glu Tyr Lys Tyr Leu Lys Asn Met Phe Arg Thr Tyr 
    210                 215                 220                 


Gln Asp Ser Ile Tyr Asp Glu Met Glu Glu Lys Trp Ser Lys Gln Lys 
225                 230                 235                 240 


Ala Lys Trp Lys Lys Asp Glu Lys Phe Glu Arg Glu Asn Ile Leu Leu 
                245                 250                 255     


Gln Gln Lys Lys Lys Met Thr Lys Lys Phe Glu Met Glu Ser Gly Glu 
            260                 265                 270         


Glu Asp Lys Lys Ile Asn Glu Ser Cys Ser Ala Val Phe Glu Asn Phe 
        275                 280                 285             


Ile Gln Glu Lys Glu Glu Leu Leu Lys Gln His Gln Ser Asp Thr Leu 
    290                 295                 300                 


Gln Leu Glu Glu Leu Arg Lys Thr Lys Glu Val Met Gln Glu Glu Leu 
305                 310                 315                 320 


His Ala Gln Ala Leu Ile Leu Glu Ser Leu Asn Thr Asn Leu Tyr Tyr 
                325                 330                 335     


Thr Gln Leu Glu Leu Gln Lys Glu Lys Ala Ile Val Gly Asn Leu Glu 
            340                 345                 350         


Lys Met Leu Gln Thr Lys Phe Ala Glu Thr Glu Glu Lys Tyr Lys His 
        355                 360                 365             


Thr Ile Gln Ile Leu Thr Glu Glu Asn Ile His Leu Lys Gln Lys Ile 
    370                 375                 380                 


Ile Ser Lys Asn Glu Glu Ile Cys Glu Gly Cys Ser Gly Arg Leu Ala 
385                 390                 395                 400 


Ser Ile Thr Val Ser Lys Asp Asp Ser Asp Thr Val Gln Asp Gly Ser 
                405                 410                 415     


Lys Lys Gly Gln Glu Ser 
            420         


<210>  479
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALS2__Homo_sapiens__NP_001129217

<400>  479

Met Asp Ser Lys Lys Arg Ser Ser Thr Glu Ala Glu Gly Ser Lys Glu 
1               5                   10                  15      


Arg Gly Leu Val His Ile Trp Gln Ala Gly Ser Phe Pro Ile Thr Pro 
            20                  25                  30          


Glu Arg Leu Pro Gly Trp Gly Gly Lys Thr Val Leu Gln Ala Ala Leu 
        35                  40                  45              


Gly Val Lys His Gly Val Leu Leu Thr Glu Asp Gly Glu Val Tyr Ser 
    50                  55                  60                  


Phe Gly Thr Leu Pro Trp Arg Ser Gly Pro Val Glu Ile Cys Pro Ser 
65                  70                  75                  80  


Ser Pro Ile Leu Glu Asn Ala Leu Val Gly Gln Tyr Val Ile Thr Val 
                85                  90                  95      


Ala Thr Gly Ser Phe His Ser Gly Ala Val Thr Asp Asn Gly Val Ala 
            100                 105                 110         


Tyr Met Trp Gly Glu Asn Ser Ala Gly Gln Cys Ala Val Ala Asn Gln 
        115                 120                 125             


Gln Tyr Val Pro Glu Pro Asn Pro Val Ser Ile Ala Asp Ser Glu Ala 
    130                 135                 140                 


Ser Pro Leu Leu Ala Val Arg Ile Leu Gln Leu Ala Cys Gly Glu Glu 
145                 150                 155                 160 


His Thr Leu Ala Leu Ser Ile Ser Arg Glu Ile Trp Ala Trp Gly Thr 
                165                 170                 175     


Gly Cys Gln Leu Gly Leu Ile Thr Thr Ala Phe Pro Val Thr Lys Pro 
            180                 185                 190         


Gln Lys Val Glu His Leu Ala Gly Arg Val Val Leu Gln Val Ala Cys 
        195                 200                 205             


Gly Ala Phe His Ser Leu Ala Leu Val Gln Cys Leu Pro Ser Gln Asp 
    210                 215                 220                 


Leu Lys Pro Val Pro Glu Arg Cys Asn Gln Cys Ser Gln Leu Leu Ile 
225                 230                 235                 240 


Thr Met Thr Asp Lys Glu Asp His Val Ile Ile Ser Asp Ser His Cys 
                245                 250                 255     


Cys Pro Leu Gly Val Thr Leu Thr Glu Ser Gln Ala Glu Asn His Ala 
            260                 265                 270         


Ser Thr Ala Leu Ser Pro Ser Thr Glu Thr Leu Asp Arg Gln Glu Glu 
        275                 280                 285             


Val Phe Glu Asn Thr Leu Val Ala Asn Asp Gln Ser Val Ala Thr Glu 
    290                 295                 300                 


Leu Asn Ala Val Ser Ala Gln Ile Thr Ser Ser Asp Ala Met Ser Ser 
305                 310                 315                 320 


Gln Gln Asn Val Met Gly Thr Thr Glu Ile Ser Ser Ala Arg Asn Ile 
                325                 330                 335     


Pro Ser Tyr Pro Asp Thr Gln Ala Val Asn Glu Tyr Leu Arg Lys Leu 
            340                 345                 350         


Ser Asp His Ser Val Arg Glu Asp Ser Glu His Gly Glu Lys Pro Val 
        355                 360                 365             


Pro Ser Gln Val Pro Ala Gln Phe Tyr Lys Ile Lys Val Cys Leu Glu 
    370                 375                 380                 


Leu Asn Cys Met Gly Phe Ser Leu Glu Thr Leu Lys 
385                 390                 395     


<210>  480
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALX1__Homo_sapiens__XP_005269222

<400>  480

Met Glu Phe Leu Ser Glu Lys Phe Ala Leu Lys Ser Pro Pro Ser Lys 
1               5                   10                  15      


Asn Ser Asp Phe Tyr Met Gly Ala Gly Gly Pro Leu Glu His Val Met 
            20                  25                  30          


Glu Thr Leu Asp Asn Glu Ser Phe Tyr Ser Lys Ala Ser Ala Gly Lys 
        35                  40                  45              


Cys Val Gln Ala Phe Gly Pro Leu Pro Arg Ala Glu His His Val Arg 
    50                  55                  60                  


Leu Glu Arg Thr Ser Pro Cys Gln Asp Ser Ser Val Asn Tyr Gly Ile 
65                  70                  75                  80  


Thr Lys Val Glu Gly Gln Pro Leu His Thr Glu Leu Asn Arg Ala Met 
                85                  90                  95      


Asp Asn Cys Asn Ser Leu Arg Met Ser Pro Val Lys Gly Met Gln Glu 
            100                 105                 110         


Lys Gly Glu Leu Asp Glu Leu Gly Asp Lys Cys Asp Ser Asn Val Ser 
        115                 120                 125             


Ser Ser Lys Lys Arg Arg His Arg Thr Thr Phe Thr Ser Leu Gln Leu 
    130                 135                 140                 


Glu Glu Leu Glu Lys Val Phe Gln Lys Thr His Tyr Pro Asp Val Tyr 
145                 150                 155                 160 


Val Arg Glu Gln Leu Ala Leu Arg Thr Glu Leu Thr Glu Ala Arg Val 
                165                 170                 175     


Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg Glu Arg 
            180                 185                 190         


Tyr Gly Gln Ile Gln Gln Ala Lys Ser His Phe Ala Ala Thr Tyr Asp 
        195                 200                 205             


Ile Ser Val Leu Pro Arg Thr Asp Ser Tyr Pro Gln Ile Gln Asn Asn 
    210                 215                 220                 


Leu Trp Ala Gly Asn Ala Ser Gly Gly Ser Val Val Thr Ser Cys Met 
225                 230                 235                 240 


Leu Pro Arg Asp Thr Ser Ser Cys Met Thr Pro Tyr Ser His Ser Pro 
                245                 250                 255     


Arg Thr Asp Ser Ser Tyr Thr Gly Phe Ser Asn His Gln Asn Gln Phe 
            260                 265                 270         


Ser His Val Pro Leu Asn Asn Phe Phe Thr Asp Ser Leu Leu Thr Gly 
        275                 280                 285             


Ala Thr Asn Gly His Ala Phe Glu Thr Lys Pro Glu Phe Glu Arg Arg 
    290                 295                 300                 


Ser Ser Ser Ile Ala Val Leu Arg Met Lys Ala Lys Glu His Thr Ala 
305                 310                 315                 320 


Asn Ile Ser Trp Ala Met 
                325     


<210>  481
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALX4__Homo_sapiens__NP_068745

<400>  481

Met Asn Ala Glu Thr Cys Val Ser Tyr Cys Glu Ser Pro Ala Ala Ala 
1               5                   10                  15      


Met Asp Ala Tyr Tyr Ser Pro Val Ser Gln Ser Arg Glu Gly Ser Ser 
            20                  25                  30          


Pro Phe Arg Ala Phe Pro Gly Gly Asp Lys Phe Gly Thr Thr Phe Leu 
        35                  40                  45              


Ser Ala Ala Ala Lys Ala Gln Gly Phe Gly Asp Ala Lys Ser Arg Ala 
    50                  55                  60                  


Arg Tyr Gly Ala Gly Gln Gln Asp Leu Ala Thr Pro Leu Glu Ser Gly 
65                  70                  75                  80  


Ala Gly Ala Arg Gly Ser Phe Asn Lys Phe Gln Pro Gln Pro Ser Thr 
                85                  90                  95      


Pro Gln Pro Gln Pro Pro Pro Gln Pro Gln Pro Gln Gln Gln Gln Pro 
            100                 105                 110         


Gln Pro Gln Pro Pro Ala Gln Pro His Leu Tyr Leu Gln Arg Gly Ala 
        115                 120                 125             


Cys Lys Thr Pro Pro Asp Gly Ser Leu Lys Leu Gln Glu Gly Ser Ser 
    130                 135                 140                 


Gly His Ser Ala Ala Leu Gln Val Pro Cys Tyr Ala Lys Glu Ser Ser 
145                 150                 155                 160 


Leu Gly Glu Pro Glu Leu Pro Pro Asp Ser Asp Thr Val Gly Met Asp 
                165                 170                 175     


Ser Ser Tyr Leu Ser Val Lys Glu Ala Gly Val Lys Gly Pro Gln Asp 
            180                 185                 190         


Arg Ala Ser Ser Asp Leu Pro Ser Pro Leu Glu Lys Ala Asp Ser Glu 
        195                 200                 205             


Ser Asn Lys Gly Lys Lys Arg Arg Asn Arg Thr Thr Phe Thr Ser Tyr 
    210                 215                 220                 


Gln Leu Glu Glu Leu Glu Lys Val Phe Gln Lys Thr His Tyr Pro Asp 
225                 230                 235                 240 


Val Tyr Ala Arg Glu Gln Leu Ala Met Arg Thr Asp Leu Thr Glu Ala 
                245                 250                 255     


Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg 
            260                 265                 270         


Glu Arg Phe Gly Gln Met Gln Gln Val Arg Thr His Phe Ser Thr Ala 
        275                 280                 285             


Tyr Glu Leu Pro Leu Leu Thr Arg Ala Glu Asn Tyr Ala Gln Ile Gln 
    290                 295                 300                 


Asn Pro Ser Trp Leu Gly Asn Asn Gly Ala Ala Ser Pro Val Pro Ala 
305                 310                 315                 320 


Cys Val Val Pro Cys Asp Pro Val Pro Ala Cys Met Ser Pro His Ala 
                325                 330                 335     


His Pro Pro Gly Ser Gly Ala Ser Ser Val Thr Asp Phe Leu Ser Val 
            340                 345                 350         


Ser Gly Ala Gly Ser His Val Gly Gln Thr His Met Gly Ser Leu Phe 
        355                 360                 365             


Gly Ala Ala Ser Leu Ser Pro Gly Leu Asn Gly Tyr Glu Leu Asn Gly 
    370                 375                 380                 


Glu Pro Asp Arg Lys Thr Ser Ser Ile Ala Ala Leu Arg Met Lys Ala 
385                 390                 395                 400 


Lys Glu His Ser Ala Ala Ile Ser Trp Ala Thr 
                405                 410     


<210>  482
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALYREF__Homo_sapiens__NP_005773

<400>  482

Met Pro Asp Ser Ala Pro Ala Met Ala Asp Lys Met Asp Met Ser Leu 
1               5                   10                  15      


Asp Asp Ile Ile Lys Leu Asn Arg Ser Gln Arg Gly Gly Arg Gly Gly 
            20                  25                  30          


Gly Arg Gly Arg Gly Arg Ala Gly Ser Gln Gly Gly Arg Gly Gly Gly 
        35                  40                  45              


Ala Gln Ala Ala Ala Arg Val Asn Arg Gly Gly Gly Pro Ile Arg Asn 
    50                  55                  60                  


Arg Pro Ala Ile Ala Arg Gly Ala Ala Gly Gly Gly Gly Arg Asn Arg 
65                  70                  75                  80  


Pro Ala Pro Tyr Ser Arg Pro Lys Gln Leu Pro Asp Lys Trp Gln His 
                85                  90                  95      


Asp Leu Phe Asp Ser Gly Phe Gly Gly Gly Ala Gly Val Glu Thr Gly 
            100                 105                 110         


Gly Lys Leu Leu Val Ser Asn Leu Asp Phe Gly Val Ser Asp Ala Asp 
        115                 120                 125             


Ile Gln Glu Leu Phe Ala Glu Phe Gly Thr Leu Lys Lys Ala Ala Val 
    130                 135                 140                 


His Tyr Asp Arg Ser Gly Arg Ser Leu Gly Thr Ala Asp Val His Phe 
145                 150                 155                 160 


Glu Arg Lys Ala Asp Ala Leu Lys Ala Met Lys Gln Tyr Asn Gly Val 
                165                 170                 175     


Pro Leu Asp Gly Arg Pro Met Asn Ile Gln Leu Val Thr Ser Gln Ile 
            180                 185                 190         


Asp Ala Gln Arg Arg Pro Ala Gln Ser Val Asn Arg Gly Gly Met Thr 
        195                 200                 205             


Arg Asn Arg Gly Ala Gly Gly Phe Gly Gly Gly Gly Gly Thr Arg Arg 
    210                 215                 220                 


Gly Thr Arg Gly Gly Ala Arg Gly Arg Gly Arg Gly Ala Gly Arg Asn 
225                 230                 235                 240 


Ser Lys Gln Gln Leu Ser Ala Glu Glu Leu Asp Ala Gln Leu Asp Ala 
                245                 250                 255     


Tyr Asn Ala Arg Met Asp Thr Ser 
            260                 


<210>  483
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMACR__Homo_sapiens__NP_001161067

<400>  483

Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
1               5                   10                  15      


Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
            20                  25                  30          


Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
        35                  40                  45              


Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
65                  70                  75                  80  


Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                85                  90                  95      


Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
            100                 105                 110         


Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
        115                 120                 125             


Leu Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr 
    130                 135                 140                 


Ala Pro Leu Asn Leu Leu Ala Asp Phe Ala Gly Gly Gly Leu Met Cys 
145                 150                 155                 160 


Ala Leu Gly Ile Ile Met Ala Leu Phe Asp Arg Thr Arg Thr Gly Lys 
                165                 170                 175     


Gly Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 
            180                 185                 190         


Ser Phe Leu Trp Lys Thr Gln Lys Leu Ser Leu Trp Glu Ala Pro Arg 
        195                 200                 205             


Gly Gln Asn Met Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Arg 
    210                 215                 220                 


Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe 
225                 230                 235                 240 


Tyr Glu Leu Leu Ile Lys Gly Leu Gly Leu Lys Ser Asp Glu Leu Pro 
                245                 250                 255     


Asn Gln Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 
            260                 265                 270         


Asp Val Phe Ala Glu Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp 
        275                 280                 285             


Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 
    290                 295                 300                 


His His Asp His Asn Lys Glu Arg Gly Ser Phe Ile Thr Ser Glu Glu 
305                 310                 315                 320 


Gln Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 
                325                 330                 335     


Ile Pro Ser Phe Lys Arg Asp Pro Phe Ile Gly Glu His Thr Glu Glu 
            340                 345                 350         


Ile Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu Ile Tyr Gln Leu Asn 
        355                 360                 365             


Ser Asp Lys Ile Ile Glu Ser Asn Lys Ala Gly Ser Lys Phe Trp Ile 
    370                 375                 380                 


Leu Tyr Pro Thr His Ser Asn Ile Gln Lys 
385                 390                 


<210>  484
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMBN__Homo_sapiens__NP_057603

<400>  484

Met Ser Ala Ser Lys Ile Pro Leu Phe Lys Met Lys Asp Leu Ile Leu 
1               5                   10                  15      


Ile Leu Cys Leu Leu Glu Met Ser Phe Ala Val Pro Phe Phe Pro Gln 
            20                  25                  30          


Gln Ser Gly Thr Pro Gly Met Ala Ser Leu Ser Leu Glu Thr Met Arg 
        35                  40                  45              


Gln Leu Gly Ser Leu Gln Arg Leu Asn Thr Leu Ser Gln Tyr Ser Arg 
    50                  55                  60                  


Tyr Gly Phe Gly Lys Ser Phe Asn Ser Leu Trp Met His Gly Leu Leu 
65                  70                  75                  80  


Pro Pro His Ser Ser Leu Pro Trp Met Arg Pro Arg Glu His Glu Thr 
                85                  90                  95      


Gln Gln Tyr Glu Tyr Ser Leu Pro Val His Pro Pro Pro Leu Pro Ser 
            100                 105                 110         


Gln Pro Ser Leu Lys Pro Gln Gln Pro Gly Leu Lys Pro Phe Leu Gln 
        115                 120                 125             


Ser Ala Ala Ala Thr Thr Asn Gln Ala Thr Ala Leu Lys Glu Ala Leu 
    130                 135                 140                 


Gln Pro Pro Ile His Leu Gly His Leu Pro Leu Gln Glu Gly Glu Leu 
145                 150                 155                 160 


Pro Leu Val Gln Gln Gln Val Ala Pro Ser Asp Lys Pro Pro Lys Pro 
                165                 170                 175     


Glu Leu Pro Gly Val Asp Phe Ala Asp Pro Gln Gly Pro Ser Leu Pro 
            180                 185                 190         


Gly Met Asp Phe Pro Asp Pro Gln Gly Pro Ser Leu Pro Gly Leu Asp 
        195                 200                 205             


Phe Ala Asp Pro Gln Gly Ser Thr Ile Phe Gln Ile Ala Arg Leu Ile 
    210                 215                 220                 


Ser His Gly Pro Met Pro Gln Asn Lys Gln Ser Pro Leu Tyr Pro Gly 
225                 230                 235                 240 


Met Leu Tyr Val Pro Phe Gly Ala Asn Gln Leu Asn Ala Pro Ala Arg 
                245                 250                 255     


Leu Gly Ile Met Ser Ser Glu Glu Val Ala Gly Gly Arg Glu Asp Pro 
            260                 265                 270         


Met Ala Tyr Gly Ala Met Phe Pro Gly Phe Gly Gly Met Arg Pro Gly 
        275                 280                 285             


Phe Glu Gly Met Pro His Asn Pro Ala Met Gly Gly Asp Phe Thr Leu 
    290                 295                 300                 


Glu Phe Asp Ser Pro Val Ala Ala Thr Lys Gly Pro Glu Asn Glu Glu 
305                 310                 315                 320 


Gly Gly Ala Gln Gly Ser Pro Met Pro Glu Ala Asn Pro Asp Asn Leu 
                325                 330                 335     


Glu Asn Pro Ala Phe Leu Thr Glu Leu Glu Pro Ala Pro His Ala Gly 
            340                 345                 350         


Leu Leu Ala Leu Pro Lys Asp Asp Ile Pro Gly Leu Pro Arg Ser Pro 
        355                 360                 365             


Ser Gly Lys Met Lys Gly Leu Pro Ser Val Thr Pro Ala Ala Ala Asp 
    370                 375                 380                 


Pro Leu Met Thr Pro Glu Leu Ala Asp Val Tyr Arg Thr Tyr Asp Ala 
385                 390                 395                 400 


Asp Met Thr Thr Ser Val Asp Phe Gln Glu Glu Ala Thr Met Asp Thr 
                405                 410                 415     


Thr Met Ala Pro Asn Ser Leu Gln Thr Ser Met Pro Gly Asn Lys Ala 
            420                 425                 430         


Gln Glu Pro Glu Met Met His Asp Ala Trp His Phe Gln Glu Pro 
        435                 440                 445         


<210>  485
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMBP__Homo_sapiens__NP_001624

<400>  485

Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala 
1               5                   10                  15      


Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln 
            20                  25                  30          


Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala 
        35                  40                  45              


Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr 
    50                  55                  60                  


Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser 
65                  70                  75                  80  


Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly 
                85                  90                  95      


Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser 
            100                 105                 110         


Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp 
        115                 120                 125             


Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro 
    130                 135                 140                 


Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr 
145                 150                 155                 160 


Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu 
                165                 170                 175     


Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu 
            180                 185                 190         


Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu 
        195                 200                 205             


Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val 
    210                 215                 220                 


Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys 
225                 230                 235                 240 


Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys 
                245                 250                 255     


Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val 
            260                 265                 270         


Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn 
        275                 280                 285             


Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala 
    290                 295                 300                 


Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys 
305                 310                 315                 320 


Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr 
                325                 330                 335     


Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn 
            340                 345                 350         


<210>  486
<211>  1301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMBRA1__Homo_sapiens__NP_001254711

<400>  486

Met Lys Val Val Pro Glu Lys Asn Ala Val Arg Ile Leu Trp Gly Arg 
1               5                   10                  15      


Glu Arg Gly Ala Arg Ala Met Gly Ala Gln Arg Leu Leu Gln Glu Leu 
            20                  25                  30          


Val Glu Asp Lys Thr Arg Trp Met Lys Trp Glu Gly Lys Arg Val Glu 
        35                  40                  45              


Leu Pro Asp Ser Pro Arg Ser Thr Phe Leu Leu Ala Phe Ser Pro Asp 
    50                  55                  60                  


Arg Thr Leu Leu Ala Ser Thr His Val Asn His Asn Ile Tyr Ile Thr 
65                  70                  75                  80  


Glu Val Lys Thr Gly Lys Cys Val His Ser Leu Ile Gly His Arg Arg 
                85                  90                  95      


Thr Pro Trp Cys Val Thr Phe His Pro Thr Ile Ser Gly Leu Ile Ala 
            100                 105                 110         


Ser Gly Cys Leu Asp Gly Glu Val Arg Ile Trp Asp Leu His Gly Gly 
        115                 120                 125             


Ser Glu Ser Trp Phe Thr Asp Ser Asn Asn Ala Ile Ala Ser Leu Ala 
    130                 135                 140                 


Phe His Pro Thr Ala Gln Leu Leu Leu Ile Ala Thr Ala Asn Glu Ile 
145                 150                 155                 160 


His Phe Trp Asp Trp Ser Arg Arg Glu Pro Phe Ala Val Val Lys Thr 
                165                 170                 175     


Ala Ser Glu Met Glu Arg Val Arg Leu Val Arg Phe Asp Pro Leu Gly 
            180                 185                 190         


His Tyr Leu Leu Thr Ala Ile Val Asn Pro Ser Asn Gln Gln Gly Asp 
        195                 200                 205             


Asp Glu Pro Glu Ile Pro Ile Asp Gly Thr Glu Leu Ser His Tyr Arg 
    210                 215                 220                 


Gln Arg Ala Leu Leu Gln Ser Gln Pro Val Arg Arg Thr Pro Leu Leu 
225                 230                 235                 240 


His Asn Phe Leu His Met Leu Ser Ser Arg Ser Ser Gly Ile Gln Thr 
                245                 250                 255     


Glu Pro Phe His Pro Pro Glu Gln Ala Ser Ser Thr Gln Gln Asp Gln 
            260                 265                 270         


Gly Leu Leu Asn Arg Pro Ser Ala Phe Ser Thr Val Gln Ser Ser Thr 
        275                 280                 285             


Ala Gly Asn Thr Leu Arg Asn Leu Ser Leu Gly Pro Thr Arg Arg Ser 
    290                 295                 300                 


Leu Gly Gly Pro Leu Ser Ser His Pro Ser Arg Tyr His Arg Glu Ile 
305                 310                 315                 320 


Ala Pro Gly Leu Thr Gly Ser Glu Trp Thr Arg Thr Val Leu Ser Leu 
                325                 330                 335     


Asn Ser Arg Ser Glu Ala Glu Ser Met Pro Pro Pro Arg Thr Ser Ala 
            340                 345                 350         


Ser Ser Val Ser Leu Leu Ser Val Leu Arg Gln Gln Glu Gly Gly Ser 
        355                 360                 365             


Gln Ala Ser Val Tyr Thr Ser Ala Thr Glu Gly Arg Gly Phe Pro Ala 
    370                 375                 380                 


Ser Gly Leu Ala Thr Glu Ser Asp Gly Gly Asn Gly Ser Ser Gln Asn 
385                 390                 395                 400 


Asn Ser Gly Ser Ile Arg His Glu Leu Gln Cys Asp Leu Arg Arg Phe 
                405                 410                 415     


Phe Leu Glu Tyr Asp Arg Leu Gln Glu Leu Asp Gln Ser Leu Ser Gly 
            420                 425                 430         


Glu Ala Pro Gln Thr Gln Gln Ala Gln Glu Met Leu Asn Asn Asn Ile 
        435                 440                 445             


Glu Ser Glu Arg Pro Gly Pro Ser His Gln Pro Thr Pro His Ser Ser 
    450                 455                 460                 


Glu Asn Asn Ser Asn Leu Ser Arg Gly His Leu Asn Arg Cys Arg Ala 
465                 470                 475                 480 


Cys His Asn Leu Leu Thr Phe Asn Asn Asp Thr Leu Arg Trp Glu Arg 
                485                 490                 495     


Thr Thr Pro Asn Tyr Ser Ser Gly Glu Ala Ser Ser Ser Trp Gln Val 
            500                 505                 510         


Pro Ser Ser Phe Glu Ser Val Pro Ser Ser Gly Ser Gln Leu Pro Pro 
        515                 520                 525             


Leu Glu Arg Thr Glu Gly Gln Thr Pro Ser Ser Ser Arg Leu Glu Leu 
    530                 535                 540                 


Ser Ser Ser Ala Ser Pro Gln Glu Glu Arg Thr Val Gly Val Ala Phe 
545                 550                 555                 560 


Asn Gln Glu Thr Gly His Trp Glu Arg Ile Tyr Thr Gln Ser Ser Arg 
                565                 570                 575     


Ser Gly Thr Val Ser Gln Glu Ala Leu His Gln Asp Met Pro Glu Glu 
            580                 585                 590         


Ser Ser Glu Glu Asp Ser Leu Arg Arg Arg Ser Leu Ala Leu Ser Pro 
        595                 600                 605             


Arg Leu Glu Tyr Ser Gly Ala Ile Leu Ala His Cys Lys Leu Arg Leu 
    610                 615                 620                 


Pro Gly Ser Cys His Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Thr 
625                 630                 635                 640 


Thr Gly Ala His His His Ala Arg Leu Ile Phe Ala Phe Leu Val Glu 
                645                 650                 655     


Met Glu Phe His His Val Ser Gln Ala Gly Leu Glu Leu Leu Thr Ser 
            660                 665                 670         


Gly Asp Leu Pro Thr Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
        675                 680                 685             


Ser His Arg Ala Trp Pro Arg Leu Leu Glu Ser Ser Leu Ile Ser Leu 
    690                 695                 700                 


Ser Arg Tyr Asp Gly Ala Gly Ser Arg Glu His Pro Ile Tyr Pro Asp 
705                 710                 715                 720 


Pro Ala Arg Leu Ser Pro Ala Ala Tyr Tyr Ala Gln Arg Met Ile Gln 
                725                 730                 735     


Tyr Leu Ser Arg Arg Asp Ser Ile Arg Gln Arg Ser Met Arg Tyr Gln 
            740                 745                 750         


Gln Asn Arg Leu Arg Ser Ser Thr Ser Ser Ser Ser Ser Asp Asn Gln 
        755                 760                 765             


Gly Pro Ser Val Glu Gly Thr Asp Leu Glu Phe Glu Asp Phe Glu Asp 
    770                 775                 780                 


Asn Gly Asp Arg Ser Arg His Arg Ala Pro Arg Asn Ala Arg Met Ser 
785                 790                 795                 800 


Ala Pro Ser Leu Gly Arg Phe Val Pro Arg Arg Phe Leu Leu Pro Glu 
                805                 810                 815     


Tyr Leu Pro Tyr Ala Gly Ile Phe His Glu Arg Gly Gln Pro Gly Leu 
            820                 825                 830         


Ala Thr His Ser Ser Val Asn Arg Val Leu Ala Gly Ala Val Ile Gly 
        835                 840                 845             


Asp Gly Gln Ser Ala Val Ala Ser Asn Ile Ala Asn Thr Thr Tyr Arg 
    850                 855                 860                 


Leu Gln Trp Trp Asp Phe Thr Lys Phe Asp Leu Pro Glu Ile Ser Asn 
865                 870                 875                 880 


Ala Ser Val Asn Val Leu Val Gln Asn Cys Lys Ile Tyr Asn Asp Ala 
                885                 890                 895     


Ser Cys Asp Ile Ser Ala Asp Gly Gln Leu Leu Ala Ala Phe Ile Pro 
            900                 905                 910         


Ser Ser Gln Arg Gly Phe Pro Asp Glu Gly Ile Leu Ala Val Tyr Ser 
        915                 920                 925             


Leu Ala Pro His Asn Leu Gly Glu Met Leu Tyr Thr Lys Arg Phe Gly 
    930                 935                 940                 


Pro Asn Ala Ile Ser Val Ser Leu Ser Pro Met Gly Arg Tyr Val Met 
945                 950                 955                 960 


Val Gly Leu Ala Ser Arg Arg Ile Leu Leu His Pro Ser Thr Glu His 
                965                 970                 975     


Met Val Ala Gln Val Phe Arg Leu Gln Gln Ala His Gly Gly Glu Thr 
            980                 985                 990         


Ser Met Arg Arg Val Phe Asn Val  Leu Tyr Pro Met Pro  Ala Asp Gln 
        995                 1000                 1005             


Arg Arg  His Val Ser Ile Asn  Ser Ala Arg Trp Leu  Pro Glu Pro 
    1010                 1015                 1020             


Gly Leu  Gly Leu Ala Tyr Gly  Thr Asn Lys Gly Asp  Leu Val Ile 
    1025                 1030                 1035             


Cys Arg  Pro Glu Ala Leu Asn  Ser Gly Val Glu Tyr  Tyr Trp Asp 
    1040                 1045                 1050             


Gln Leu  Asn Glu Thr Val Phe  Thr Val His Ser Asn  Ser Arg Ser 
    1055                 1060                 1065             


Ser Glu  Arg Pro Gly Thr Ser  Arg Ala Thr Trp Arg  Thr Asp Arg 
    1070                 1075                 1080             


Asp Met  Gly Leu Met Asn Ala  Ile Gly Leu Gln Pro  Arg Asn Pro 
    1085                 1090                 1095             


Ala Thr  Ser Val Thr Ser Gln  Gly Thr Gln Thr Leu  Ala Leu Gln 
    1100                 1105                 1110             


Leu Gln  Asn Ala Glu Thr Gln  Thr Glu Arg Glu Val  Pro Glu Pro 
    1115                 1120                 1125             


Gly Thr  Ala Ala Ser Gly Pro  Gly Glu Gly Glu Gly  Ser Glu Tyr 
    1130                 1135                 1140             


Gly Ala  Ser Gly Glu Asp Ala  Leu Ser Arg Ile Gln  Arg Leu Met 
    1145                 1150                 1155             


Ala Glu  Gly Gly Met Thr Ala  Val Val Gln Arg Glu  Gln Ser Thr 
    1160                 1165                 1170             


Thr Met  Ala Ser Met Gly Gly  Phe Gly Asn Asn Ile  Ile Val Ser 
    1175                 1180                 1185             


His Arg  Ile His Arg Ser Ser  Gln Thr Gly Thr Glu  Pro Gly Ala 
    1190                 1195                 1200             


Ala His  Thr Ser Ser Pro Gln  Pro Ser Thr Ser Arg  Gly Leu Leu 
    1205                 1210                 1215             


Pro Glu  Ala Gly Gln Leu Ala  Glu Arg Gly Leu Ser  Pro Arg Thr 
    1220                 1225                 1230             


Ala Ser  Trp Asp Gln Pro Gly  Thr Pro Gly Arg Glu  Pro Thr Gln 
    1235                 1240                 1245             


Pro Thr  Leu Pro Ser Ser Ser  Pro Val Pro Ile Pro  Val Ser Leu 
    1250                 1255                 1260             


Pro Ser  Ala Glu Gly Pro Thr  Leu His Cys Glu Leu  Thr Asn Asn 
    1265                 1270                 1275             


Asn His  Leu Leu Asp Gly Gly  Ser Ser Arg Gly Asp  Ala Ala Gly 
    1280                 1285                 1290             


Pro Arg  Gly Glu Pro Arg Asn  Arg 
    1295                 1300     


<210>  487
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMD1__Homo_sapiens__NP_001274143

<400>  487

Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 
1               5                   10                  15      


Trp Phe Ser Arg Gln Gln Pro Asp Ala Asn Gln Gly Ser Gly Asp Leu 
            20                  25                  30          


Arg Thr Ile Pro Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe 
        35                  40                  45              


Ile Leu Lys Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro 
    50                  55                  60                  


Leu Leu Lys Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser 
65                  70                  75                  80  


Phe Phe Tyr Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr 
                85                  90                  95      


Pro His Arg Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe 
            100                 105                 110         


Pro Asn Gly Ala Ala Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp 
        115                 120                 125             


Tyr Leu Tyr Thr Leu Asp Phe Pro Glu Ser Arg Val Ile Ser Gln Pro 
    130                 135                 140                 


Asp Gln Thr Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met 
145                 150                 155                 160 


Asp Gln Phe Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg 
                165                 170                 175     


Glu Ser Gly Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr 
            180                 185                 190         


Met Phe Asn Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly 
        195                 200                 205             


Thr Tyr Trp Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val 
    210                 215                 220                 


Ser Phe Glu Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg 
225                 230                 235                 240 


Lys Val Val Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe 
                245                 250                 255     


Val Asn Gln Ser Ser Lys Cys Arg Thr Val Leu Ala Ser Pro Gln Lys 
            260                 265                 270         


Ile Glu Gly Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp 
        275                 280                 285             


Tyr Asn Phe Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Gln 
    290                 295                 300                 


Ser 
305 


<210>  488
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMELX__Homo_sapiens__NP_001133

<400>  488

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Leu Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Ile Arg Pro Pro 
        35                  40                  45              


Tyr Pro Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His Gln 
    50                  55                  60                  


Ile Ile Pro Val Leu Ser Gln Gln His Pro Pro Thr His Thr Leu Gln 
65                  70                  75                  80  


Pro His His His Ile Pro Val Val Pro Ala Gln Gln Pro Val Ile Pro 
                85                  90                  95      


Gln Gln Pro Met Met Pro Val Pro Gly Gln His Ser Met Thr Pro Ile 
            100                 105                 110         


Gln His His Gln Pro Asn Leu Pro Pro Pro Ala Gln Gln Pro Tyr Gln 
        115                 120                 125             


Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln Pro 
    130                 135                 140                 


Pro Val His Pro Met Gln Pro Leu Pro Pro Gln Pro Pro Leu Pro Pro 
145                 150                 155                 160 


Met Phe Pro Met Gln Pro Leu Pro Pro Met Leu Pro Asp Leu Thr Leu 
                165                 170                 175     


Glu Ala Trp Pro Ser Thr Asp Lys Thr Lys Arg Glu Glu Val Asp 
            180                 185                 190     


<210>  489
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMELY__Homo_sapiens__NP_001134

<400>  489

Met Gly Thr Trp Ile Leu Phe Ala Cys Leu Val Gly Ala Ala Phe Ala 
1               5                   10                  15      


Met Pro Leu Pro Pro His Pro Gly His Pro Gly Tyr Ile Asn Phe Ser 
            20                  25                  30          


Tyr Glu Val Leu Thr Pro Leu Lys Trp Tyr Gln Ser Met Ile Arg Pro 
        35                  40                  45              


Pro Tyr Ser Ser Tyr Gly Tyr Glu Pro Met Gly Gly Trp Leu His His 
    50                  55                  60                  


Gln Ile Ile Pro Val Val Ser Gln Gln His Pro Leu Thr His Thr Leu 
65                  70                  75                  80  


Gln Ser His His His Ile Pro Val Val Pro Ala Gln Gln Pro Arg Val 
                85                  90                  95      


Arg Gln Gln Ala Leu Met Pro Val Pro Gly Gln Gln Ser Met Thr Pro 
            100                 105                 110         


Thr Gln His His Gln Pro Asn Leu Pro Leu Pro Ala Gln Gln Pro Phe 
        115                 120                 125             


Gln Pro Gln Pro Val Gln Pro Gln Pro His Gln Pro Met Gln Pro Gln 
    130                 135                 140                 


Pro Pro Val Gln Pro Met Gln Pro Leu Leu Pro Gln Pro Pro Leu Pro 
145                 150                 155                 160 


Pro Met Phe Pro Leu Arg Pro Leu Pro Pro Ile Leu Pro Asp Leu His 
                165                 170                 175     


Leu Glu Ala Trp Pro Ala Thr Asp Lys Thr Lys Gln Glu Glu Val Asp 
            180                 185                 190         


<210>  490
<211>  1135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMER1__Homo_sapiens__NP_689637

<400>  490

Met Glu Thr Gln Lys Asp Glu Ala Ala Gln Ala Lys Gly Ala Ala Ala 
1               5                   10                  15      


Ser Gly Ser Thr Arg Glu Gln Thr Ala Glu Lys Gly Ala Lys Asn Lys 
            20                  25                  30          


Ala Ala Glu Ala Thr Glu Gly Pro Thr Ser Glu Pro Ser Ser Ser Gly 
        35                  40                  45              


Pro Gly Arg Leu Lys Lys Thr Ala Met Lys Leu Phe Gly Gly Lys Lys 
    50                  55                  60                  


Gly Ile Cys Thr Leu Pro Ser Phe Phe Gly Gly Gly Arg Ser Lys Gly 
65                  70                  75                  80  


Ser Gly Lys Gly Ser Ser Lys Lys Gly Leu Ser Lys Ser Lys Thr His 
                85                  90                  95      


Asp Gly Leu Ser Glu Ala Ala His Gly Pro Glu Asp Val Val Ser Glu 
            100                 105                 110         


Gly Thr Gly Phe Ser Leu Pro Leu Pro Glu Leu Pro Cys Gln Phe Pro 
        115                 120                 125             


Ser Ser Gln Ser Ala His Gly Ala Leu Glu Thr Gly Ser Arg Cys Lys 
    130                 135                 140                 


Thr Ser Val Ala Gly Ala Thr Glu Lys Ala Val Ala Glu Lys Phe Pro 
145                 150                 155                 160 


Ser Met Pro Lys Pro Lys Lys Gly Leu Lys Gly Phe Phe Ser Ser Ile 
                165                 170                 175     


Arg Arg His Arg Lys Ser Lys Val Thr Gly Ala Glu Gln Ser Glu Pro 
            180                 185                 190         


Gly Ala Lys Gly Pro Glu Arg Val Arg Ala Arg Pro His Glu His Val 
        195                 200                 205             


Ser Ser Ala Pro Gln Val Pro Cys Phe Glu Glu Thr Phe Gln Ala Pro 
    210                 215                 220                 


Arg Lys Glu Asn Ala Asn Pro Gln Asp Ala Pro Gly Pro Lys Val Ser 
225                 230                 235                 240 


Pro Thr Pro Glu Pro Ser Pro Pro Ala Thr Glu Lys Met Ala Cys Lys 
                245                 250                 255     


Asp Pro Glu Lys Pro Met Glu Ala Cys Ala Ser Ala His Val Gln Pro 
            260                 265                 270         


Lys Pro Ala Pro Glu Ala Ser Ser Leu Glu Glu Pro His Ser Pro Glu 
        275                 280                 285             


Thr Gly Glu Lys Val Val Ala Gly Glu Val Asn Pro Pro Asn Gly Pro 
    290                 295                 300                 


Val Gly Asp Pro Leu Ser Leu Leu Phe Gly Asp Val Thr Ser Leu Lys 
305                 310                 315                 320 


Ser Phe Asp Ser Leu Thr Gly Cys Gly Asp Ile Ile Ala Glu Gln Asp 
                325                 330                 335     


Met Asp Ser Met Thr Asp Ser Met Ala Ser Gly Gly Gln Arg Ala Asn 
            340                 345                 350         


Arg Asp Gly Thr Lys Arg Ser Ser Cys Leu Val Thr Tyr Gln Gly Gly 
        355                 360                 365             


Gly Glu Glu Met Ala Leu Pro Asp Asp Asp Asp Glu Glu Glu Glu Glu 
    370                 375                 380                 


Glu Glu Glu Val Glu Leu Glu Glu Glu Glu Glu Glu Val Lys Glu Glu 
385                 390                 395                 400 


Glu Glu Asp Asp Asp Leu Glu Tyr Leu Trp Glu Thr Ala Gln Met Tyr 
                405                 410                 415     


Pro Arg Pro Asn Met Asn Leu Gly Tyr His Pro Thr Thr Ser Pro Gly 
            420                 425                 430         


His His Gly Tyr Met Leu Leu Asp Pro Val Arg Ser Tyr Pro Gly Leu 
        435                 440                 445             


Ala Pro Gly Glu Leu Leu Thr Pro Gln Ser Asp Gln Gln Glu Ser Ala 
    450                 455                 460                 


Pro Asn Ser Asp Glu Gly Tyr Tyr Asp Ser Thr Thr Pro Gly Phe Glu 
465                 470                 475                 480 


Asp Asp Ser Gly Glu Ala Leu Gly Leu Val Arg Arg Asp Cys Leu Pro 
                485                 490                 495     


Arg Asp Ser Tyr Ser Gly Asp Ala Leu Tyr Glu Phe Tyr Glu Pro Asp 
            500                 505                 510         


Asp Ser Leu Glu Asn Ser Pro Pro Gly Asp Asp Cys Leu Tyr Asp Leu 
        515                 520                 525             


His Gly Arg Ser Ser Glu Met Phe Asp Pro Phe Leu Asn Phe Glu Pro 
    530                 535                 540                 


Phe Leu Ser Ser Arg Pro Pro Gly Ala Met Glu Thr Glu Glu Glu Arg 
545                 550                 555                 560 


Leu Val Thr Ile Gln Lys Gln Leu Leu Tyr Trp Glu Leu Arg Arg Glu 
                565                 570                 575     


Gln Leu Glu Ala Gln Glu Ala Arg Ala Arg Glu Ala His Ala Arg Glu 
            580                 585                 590         


Ala His Ala Arg Glu Ala Tyr Thr Arg Glu Ala Tyr Gly Arg Glu Ala 
        595                 600                 605             


Tyr Ala Arg Glu Ala His Thr Trp Glu Ala His Gly Arg Glu Ala Arg 
    610                 615                 620                 


Thr Arg Glu Ala Gln Ala Arg Glu Val Arg Cys Arg Glu Thr Gln Val 
625                 630                 635                 640 


Arg Glu Thr Gln Ala Arg Gln Glu Lys Pro Val Leu Glu Tyr Gln Met 
                645                 650                 655     


Arg Pro Leu Gly Pro Ser Val Met Gly Leu Ala Ala Gly Val Ser Gly 
            660                 665                 670         


Thr Ser Gln Ile Ser His Arg Gly Ile Thr Ser Ala Phe Pro Thr Thr 
        675                 680                 685             


Ala Ser Ser Glu Pro Asp Trp Arg Asp Phe Arg Pro Leu Glu Lys Arg 
    690                 695                 700                 


Tyr Glu Gly Thr Cys Ser Lys Lys Asp Gln Ser Thr Cys Leu Met Gln 
705                 710                 715                 720 


Leu Phe Gln Ser Asp Ala Met Phe Glu Pro Asp Met Gln Glu Ala Asn 
                725                 730                 735     


Phe Gly Gly Ser Pro Arg Arg Ala Tyr Pro Thr Tyr Ser Pro Pro Glu 
            740                 745                 750         


Asp Pro Glu Glu Glu Glu Val Glu Lys Glu Gly Asn Ala Thr Val Ser 
        755                 760                 765             


Phe Ser Gln Ala Leu Val Glu Phe Thr Ser Asn Gly Asn Leu Phe Ser 
    770                 775                 780                 


Ser Met Ser Cys Ser Ser Asp Ser Asp Ser Ser Phe Thr Gln Asn Leu 
785                 790                 795                 800 


Pro Glu Leu Pro Pro Met Val Thr Phe Asp Ile Ala Asp Val Glu Arg 
                805                 810                 815     


Asp Gly Glu Gly Lys Cys Glu Glu Asn Pro Glu Phe His Asn Asp Glu 
            820                 825                 830         


Asp Leu Ala Ala Ser Leu Glu Ala Phe Glu Leu Gly Tyr Tyr His Lys 
        835                 840                 845             


His Ala Phe Asn Asn Tyr His Ser Arg Phe Tyr Gln Gly Leu Pro Trp 
    850                 855                 860                 


Gly Val Ser Ser Leu Pro Arg Tyr Leu Gly Leu Pro Gly Leu His Pro 
865                 870                 875                 880 


Arg Pro Pro Pro Ala Ala Met Ala Leu Asn Arg Arg Ser Arg Ser Leu 
                885                 890                 895     


Asp Thr Ala Glu Thr Leu Glu Met Glu Leu Ser Asn Ser His Leu Val 
            900                 905                 910         


Gln Gly Tyr Leu Glu Ser Asp Glu Leu Gln Ala Gln Gln Glu Asp Ser 
        915                 920                 925             


Asp Glu Glu Asp Glu Glu Glu Glu Glu Gly Glu Trp Ser Arg Asp Ser 
    930                 935                 940                 


Pro Leu Ser Leu Tyr Thr Glu Pro Pro Gly Ala Tyr Asp Trp Pro Ala 
945                 950                 955                 960 


Trp Ala Pro Cys Pro Leu Pro Val Gly Pro Gly Pro Ala Trp Ile Ser 
                965                 970                 975     


Pro Asn Gln Leu Asp Arg Pro Ser Ser Gln Ser Pro Tyr Arg Gln Ala 
            980                 985                 990         


Thr Cys Cys Ile Pro Pro Met Thr  Met Ser Ile Ser Leu  Ser Val Pro 
        995                 1000                 1005             


Glu Ser  Arg Ala Pro Gly Glu  Ser Gly Pro Gln Leu  Ala Arg Pro 
    1010                 1015                 1020             


Ser His  Leu His Leu Pro Met  Gly Pro Cys Tyr Asn  Leu Gln Pro 
    1025                 1030                 1035             


Gln Ala  Ser Gln Ser Met Arg  Ala Arg Pro Arg Asp  Val Leu Leu 
    1040                 1045                 1050             


Pro Val  Asp Glu Pro Ser Cys  Ser Ser Ser Ser Gly  Gly Phe Ser 
    1055                 1060                 1065             


Pro Ser  Pro Leu Pro Gln Ala  Lys Pro Val Gly Ile  Thr His Gly 
    1070                 1075                 1080             


Ile Pro  Gln Leu Pro Arg Val  Arg Pro Glu His Pro  Gln Pro Gln 
    1085                 1090                 1095             


Pro Thr  His Tyr Gly Pro Ser  Ser Leu Asp Leu Ser  Lys Glu Arg 
    1100                 1105                 1110             


Ala Glu  Gln Gly Ala Ser Leu  Ala Thr Ser Tyr Ser  Ser Thr Ala 
    1115                 1120                 1125             


Met Asn  Gly Asn Leu Ala Lys  
    1130                 1135 


<210>  491
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMER2__Homo_sapiens__NP_689917

<400>  491

Met Glu Thr Ser Arg Ser Arg Gly Gly Gly Gly Ala Val Ser Glu Arg 
1               5                   10                  15      


Gly Gly Ala Gly Ala Ser Val Gly Val Cys Arg Arg Lys Ala Glu Ala 
            20                  25                  30          


Gly Ala Gly Thr Gly Thr Leu Ala Ala Asp Met Asp Leu His Cys Asp 
        35                  40                  45              


Cys Ala Ala Glu Thr Pro Ala Ala Glu Pro Pro Ser Gly Lys Ile Asn 
    50                  55                  60                  


Lys Ala Ala Phe Lys Leu Phe Lys Lys Arg Lys Ser Gly Gly Thr Met 
65                  70                  75                  80  


Pro Ser Ile Phe Gly Val Lys Asn Lys Gly Asp Gly Lys Ser Ser Gly 
                85                  90                  95      


Pro Thr Gly Leu Val Arg Ser Arg Thr His Asp Gly Leu Ala Glu Val 
            100                 105                 110         


Leu Val Leu Glu Ser Gly Arg Lys Glu Glu Pro Arg Gly Gly Gly Asp 
        115                 120                 125             


Ser Gly Gly Gly Gly Gly Gly Arg Pro Asn Pro Gly Pro Pro Arg Ala 
    130                 135                 140                 


Ala Gly Pro Gly Gly Gly Ser Leu Ala Ser Ser Ser Val Ala Lys Ser 
145                 150                 155                 160 


His Ser Phe Phe Ser Leu Leu Lys Lys Asn Gly Arg Ser Glu Asn Gly 
                165                 170                 175     


Lys Gly Glu Pro Val Asp Ala Ser Lys Ala Gly Gly Lys Gln Lys Arg 
            180                 185                 190         


Gly Leu Arg Gly Leu Phe Ser Gly Met Arg Trp His Arg Lys Asp Lys 
        195                 200                 205             


Arg Ala Lys Ala Glu Ala Ala Glu Gly Arg Ala Pro Gly Gly Gly Leu 
    210                 215                 220                 


Ile Leu Pro Gly Ser Leu Thr Ala Ser Leu Glu Cys Val Lys Glu Glu 
225                 230                 235                 240 


Thr Pro Arg Ala Ala Arg Glu Pro Glu Glu Pro Ser Gln Asp Ala Pro 
                245                 250                 255     


Arg Asp Pro Ala Gly Glu Pro Ala Gly Gly Glu Glu Val Pro Ala Pro 
            260                 265                 270         


Ala Asp Arg Ala Pro Ala Arg Ser Cys Arg Glu Ala Glu Gly Leu Ala 
        275                 280                 285             


His Pro Gly Asp Thr Gly Ala Arg Gly Glu Asp Ala Ala Gly His Arg 
    290                 295                 300                 


Arg Ala Glu Pro Gly Pro Gly Glu Val Arg Thr Ala Glu Asp Ala Ser 
305                 310                 315                 320 


Arg Thr Gly Ala Val Pro Val Lys Thr Val Pro Leu Val Asp Ser Glu 
                325                 330                 335     


Gly Gly Ser Gly Arg Ala Pro Ala Ala Pro Asp Pro Ala Ser Val Asp 
            340                 345                 350         


Pro Pro Ser Asp Pro Ser Ala Asp Arg Ile Cys Leu Met Phe Ser Asp 
        355                 360                 365             


Val Thr Ser Leu Lys Ser Phe Asp Ser Leu Thr Gly Cys Gly Asp Ile 
    370                 375                 380                 


Ile Ala Asp Gln Glu Glu Glu Ala Gly Pro Ser Cys Asp Lys His Val 
385                 390                 395                 400 


Pro Gly Pro Gly Lys Pro Ala Leu Ser Lys Lys Asn Pro Gly Val Val 
                405                 410                 415     


Ala Tyr Gln Gly Gly Gly Glu Glu Met Ala Ser Pro Asp Glu Val Asp 
            420                 425                 430         


Asp Thr Tyr Leu Gln Glu Phe Trp Asp Met Leu Ser Gln Thr Glu Glu 
        435                 440                 445             


Gln Gly Pro Glu Pro Gln Glu Gly Ala Ala Lys Val Ala Ala Ala Leu 
    450                 455                 460                 


Glu Thr Lys Val Val Pro Glu Thr Pro Lys Asp Thr Arg Cys Val Glu 
465                 470                 475                 480 


Ala Ala Lys Asp Ala Ser Ser Val Lys Arg Arg Arg Leu Asn Arg Ile 
                485                 490                 495     


Pro Ile Glu Pro His Pro Lys Glu Glu Pro Lys His Pro Glu Lys Glu 
            500                 505                 510         


Gln Gln Glu Gly Val Pro Asn Ser Asp Glu Gly Tyr Trp Asp Ser Thr 
        515                 520                 525             


Thr Pro Gly Pro Glu Glu Asp Ser Ser Ser Ser Gly Lys Lys Ala Gly 
    530                 535                 540                 


Ile Pro Arg Asp Ser Tyr Ser Gly Asp Ala Leu Tyr Asp Leu Tyr Ala 
545                 550                 555                 560 


Asp Pro Asp Gly Ser Pro Ala Thr Leu Pro Gly Gly Lys Asp Asn Glu 
                565                 570                 575     


Glu Thr Ser Ser Leu Ser Arg Leu Lys Pro Val Ser Pro Gly Thr Ile 
            580                 585                 590         


Thr Cys Pro Leu Arg Thr Pro Gly Ser Leu Leu Lys Asp Ser Lys Ile 
        595                 600                 605             


Pro Ile Ser Ile Lys His Leu Thr Asn Leu Pro Ser Ser His Pro Val 
    610                 615                 620                 


Val His Gln Gln Pro Ser Arg Ser Glu Met Pro Arg Thr Lys Ile Pro 
625                 630                 635                 640 


Val Ser Lys Val Leu Val Arg Arg Val Ser Asn Arg Gly Leu Ala Gly 
                645                 650                 655     


Thr Thr Ile Arg Ala Thr Ala Cys His Asp Ser Ala Lys Lys Leu 
            660                 665                 670     


<210>  492
<211>  861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMER3__Homo_sapiens__NP_001098663

<400>  492

Met Glu Leu Lys Arg Gly Lys Thr Phe Ile Lys Ser Ser Leu Gln Val 
1               5                   10                  15      


Ser His Glu Lys Pro Pro Asp Pro Ala Ala Val Ala Ala Ala Arg Glu 
            20                  25                  30          


Gly Thr Gly Pro Trp Ser Val Leu Pro Gly Gly Gln Gln Arg Pro His 
        35                  40                  45              


Ser Glu Lys Gly Pro Gln Ala Ser Pro Ser Ala Gln Glu Tyr Asp Arg 
    50                  55                  60                  


Cys Pro Asn Lys Gly Ala Gln Leu Asp Pro Lys Gly Gly Pro Ala Ala 
65                  70                  75                  80  


Leu Cys Gly Ala Thr Phe Lys Pro Val Arg Lys Cys Lys Thr His Asp 
                85                  90                  95      


Ser Met Ser Gly Ala Gly Arg Ala Thr Ala Ala Thr Gly Gln Leu Val 
            100                 105                 110         


Gly Ser Ala Ser Phe Pro Gly Ser Pro Gly Ser Arg Arg Met Ile Asp 
        115                 120                 125             


Tyr Arg His Phe Val Pro Gln Met Pro Phe Val Pro Ala Val Ala Lys 
    130                 135                 140                 


Ser Ile Pro Arg Lys Arg Ile Ser Leu Lys Arg Pro Lys Lys Cys Phe 
145                 150                 155                 160 


Arg Asn Leu Phe His Ile Arg Arg Asn Lys Thr Glu Asp Leu Ala Ser 
                165                 170                 175     


Leu Ala Ala Glu Gly Lys Ser Leu Pro Ser Pro Gly Asp Pro Ser Asp 
            180                 185                 190         


Pro Gly Gly Arg Arg Ser Lys Ala Phe Leu Pro Pro Gly Glu Gly Pro 
        195                 200                 205             


Gly Leu Asp Gly Leu Cys Gln Asp Leu Leu Asp Ser Glu Leu Leu Ala 
    210                 215                 220                 


Asp Ala Ser Phe Gly Leu Cys Arg Ala Leu Cys Glu Asp Val Ala Ser 
225                 230                 235                 240 


Leu Gln Ser Phe Asp Ser Leu Thr Gly Cys Gly Glu Val Phe Ala Asp 
                245                 250                 255     


Glu Ser Ser Val Pro Ser Leu Glu Leu Asn Glu Gly Pro Glu Ser Pro 
            260                 265                 270         


Thr Gln Ala Ala Gln Gly Leu Glu Ser Lys Val Pro Arg Gly Pro Leu 
        275                 280                 285             


Gln Gly Ser Val Glu Gln Leu Ala Ser Pro Ala Gln Asn Glu Ala Ser 
    290                 295                 300                 


Asp Phe Thr Arg Phe Trp Asp Ser Val Asn Arg Ser Val Arg Gln Gln 
305                 310                 315                 320 


Gln Arg Ala Leu Leu Gly Pro Trp Leu Ser Gly Pro Gln Gly Thr Asp 
                325                 330                 335     


Arg Asp Gln Ser Arg Leu Asp Thr Ala Gly Leu Ala Glu Leu Pro Leu 
            340                 345                 350         


Cys Pro Cys Arg Asp Pro Arg Ser Gly Ser Lys Ala Ser Ser Ile Asp 
        355                 360                 365             


Thr Gly Thr Pro Lys Ser Glu Gln Pro Glu Ser Val Ser Thr Ser Asp 
    370                 375                 380                 


Glu Gly Tyr Tyr Asp Ser Phe Ser Pro Gly Leu Glu Glu Asp Lys Lys 
385                 390                 395                 400 


Glu Ala Glu Ser Pro Gly Thr Pro Ala Ala Thr Phe Pro Arg Asp Ser 
                405                 410                 415     


Tyr Ser Gly Asp Ala Leu Tyr Glu Leu Phe His Asp Pro Ser Glu Gly 
            420                 425                 430         


Pro Leu Gly Pro Ser Pro Asp Asp Asp Leu Cys Val Ser Glu Ser Leu 
        435                 440                 445             


Ser Gly Pro Ala Leu Gly Thr Pro Leu Ser Ile Cys Ser Phe Arg Val 
    450                 455                 460                 


Gly Ala Glu Glu Asn Leu Ala Pro Ala Pro Gly Pro Asp Leu Leu Ser 
465                 470                 475                 480 


Gln Gly Phe Leu Gln Ser Ser Trp Lys Gly Lys Glu Cys Leu Leu Lys 
                485                 490                 495     


Leu Cys Asp Thr Glu Leu Ala Ile Thr Met Gly Ile Val Ser Trp Leu 
            500                 505                 510         


Arg Arg Gly Pro Thr Pro Arg Ala Pro Pro Thr Pro Gly Gln Pro Ala 
        515                 520                 525             


Ala Pro Pro Gly Ser Gln Gly Ala Pro Arg Ala Pro Thr Glu Lys Leu 
    530                 535                 540                 


Gly Gly Arg Glu Gly Leu Ala Ser Asp Ala Gly Gly Ala Thr Val Cys 
545                 550                 555                 560 


Ser Ala Pro Ser Arg Gln Glu Leu Trp Ala His Pro Gly Thr Thr Gly 
                565                 570                 575     


Leu Leu Ala Gly Glu Ser Lys Ala Leu Gly Gly Ala Thr Gln Gly Thr 
            580                 585                 590         


Gly Thr Leu Ser Arg Asp Ala Ser Arg Glu Glu Glu Thr Arg Gly His 
        595                 600                 605             


Ser Glu Gly Leu Phe Ser Ser Met Glu Ser Ala Ala Thr Ser Thr Thr 
    610                 615                 620                 


Asp Thr Ser Gly Lys Asn Lys Ala Pro Val Pro Ser Thr Trp Pro Cys 
625                 630                 635                 640 


Ser Gln Lys Glu Pro Gly Pro Pro Gly Val Leu Gly Cys Phe Arg Gly 
                645                 650                 655     


Pro Trp Arg Pro Gly His Gly Gly Asp Thr Leu Asp Ala Glu Pro Met 
            660                 665                 670         


Leu Ala Gly Cys Val Ala Arg Val Ala Ala Leu Lys Ile Ser Ser Asn 
        675                 680                 685             


Glu Gln Pro Pro Ala Ala Trp Pro Pro Arg Gln Asp Met Gly Ser Gly 
    690                 695                 700                 


Leu Phe Gly Gln Arg Trp Ala Arg Gly Pro Asp Met Leu Glu Gln Lys 
705                 710                 715                 720 


Gln Ser Ser Ser Ser Pro Ser Met Thr Thr Ile His Gly Leu Pro Tyr 
                725                 730                 735     


Ser Ala Ser Thr Gln Asp Gln Arg Cys Arg Asp Arg Val Gln Asp Leu 
            740                 745                 750         


Ser Trp Leu Arg Val Glu Pro Thr Gly Leu Gly Val Gln Ala Trp Ala 
        755                 760                 765             


Ser Val Glu Asp Gln Pro Leu Gln Leu Ser Thr Glu Ala Val Glu Gln 
    770                 775                 780                 


Val Ala His Gly Ser Gln Leu Asp Ser Glu Pro Arg Ser Ala Pro Ala 
785                 790                 795                 800 


Ala Arg Trp Ser Ser Gln Gly His His Pro Glu Ser Leu Gly Leu Thr 
                805                 810                 815     


Leu Asn Ser Gln Gln Glu Gly Gly Val Ser Ala Ser Ala Pro Glu Cys 
            820                 825                 830         


Arg Cys Ser Leu Leu Ala Arg Glu Gly Leu Leu Cys Gly Gln Pro Glu 
        835                 840                 845             


Val Gly Ala Ser Gly Pro Ala Met Ala Glu Pro His Leu 
    850                 855                 860     


<210>  493
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMFR__Homo_sapiens__NP_001135

<400>  493

Met Pro Leu Leu Phe Leu Glu Arg Phe Pro Trp Pro Ser Leu Arg Thr 
1               5                   10                  15      


Tyr Thr Gly Leu Ser Gly Leu Ala Leu Leu Gly Thr Ile Ile Ser Ala 
            20                  25                  30          


Tyr Arg Ala Leu Ser Gln Pro Glu Ala Gly Pro Gly Glu Pro Asp Gln 
        35                  40                  45              


Leu Thr Ala Ser Leu Gln Pro Glu Pro Pro Ala Pro Ala Arg Pro Ser 
    50                  55                  60                  


Ala Gly Gly Pro Arg Ala Arg Asp Val Ala Gln Tyr Leu Leu Ser Asp 
65                  70                  75                  80  


Ser Leu Phe Val Trp Val Leu Val Asn Thr Ala Cys Cys Val Leu Met 
                85                  90                  95      


Leu Val Ala Lys Leu Ile Gln Cys Ile Val Phe Gly Pro Leu Arg Val 
            100                 105                 110         


Ser Glu Arg Gln His Leu Lys Asp Lys Phe Trp Asn Phe Ile Phe Tyr 
        115                 120                 125             


Lys Phe Ile Phe Ile Phe Gly Val Leu Asn Val Gln Thr Val Glu Glu 
    130                 135                 140                 


Val Val Met Trp Cys Leu Trp Phe Ala Gly Leu Val Phe Leu His Leu 
145                 150                 155                 160 


Met Val Gln Leu Cys Lys Asp Arg Phe Glu Tyr Leu Ser Phe Ser Pro 
                165                 170                 175     


Thr Thr Pro Met Ser Ser His Gly Arg Val Leu Ser Leu Leu Val Ala 
            180                 185                 190         


Met Leu Leu Ser Cys Cys Gly Leu Ala Ala Val Cys Ser Ile Thr Gly 
        195                 200                 205             


Tyr Thr His Gly Met His Thr Leu Ala Phe Met Ala Ala Glu Ser Leu 
    210                 215                 220                 


Leu Val Thr Val Arg Thr Ala His Val Ile Leu Arg Tyr Val Ile His 
225                 230                 235                 240 


Leu Trp Asp Leu Asn His Glu Gly Thr Trp Glu Gly Lys Gly Thr Tyr 
                245                 250                 255     


Val Tyr Tyr Thr Asp Phe Val Met Glu Leu Thr Leu Leu Ser Leu Asp 
            260                 265                 270         


Leu Met His His Ile His Met Leu Leu Phe Gly Asn Ile Trp Leu Ser 
        275                 280                 285             


Met Ala Ser Leu Val Ile Phe Met Gln Leu Arg Tyr Leu Phe His Glu 
    290                 295                 300                 


Val Gln Arg Arg Ile Arg Arg His Lys Asn Tyr Leu Arg Val Val Gly 
305                 310                 315                 320 


Asn Met Glu Ala Arg Phe Ala Val Ala Thr Pro Glu Glu Leu Ala Val 
                325                 330                 335     


Asn Asn Asp Asp Cys Ala Ile Cys Trp Asp Ser Met Gln Ala Ala Arg 
            340                 345                 350         


Lys Leu Pro Cys Gly His Leu Phe His Asn Ser Cys Leu Arg Ser Trp 
        355                 360                 365             


Leu Glu Gln Asp Thr Ser Cys Pro Thr Cys Arg Met Ser Leu Asn Ile 
    370                 375                 380                 


Ala Asp Asn Asn Arg Val Arg Glu Glu His Gln Gly Glu Asn Leu Asp 
385                 390                 395                 400 


Glu Asn Leu Val Pro Val Ala Ala Ala Glu Gly Arg Pro Arg Leu Asn 
                405                 410                 415     


Gln His Asn His Phe Phe His Phe Asp Gly Ser Arg Ile Ala Ser Trp 
            420                 425                 430         


Leu Pro Ser Phe Ser Val Glu Val Met His Thr Thr Asn Ile Leu Gly 
        435                 440                 445             


Ile Thr Gln Ala Ser Asn Ser Gln Leu Asn Ala Met Ala His Gln Ile 
    450                 455                 460                 


Gln Glu Met Phe Pro Gln Val Pro Tyr His Leu Val Leu Gln Asp Leu 
465                 470                 475                 480 


Gln Leu Thr Arg Ser Val Glu Ile Thr Thr Asp Asn Ile Leu Glu Gly 
                485                 490                 495     


Arg Ile Gln Val Pro Phe Pro Thr Gln Arg Ser Asp Ser Ile Arg Pro 
            500                 505                 510         


Ala Leu Asn Ser Pro Val Glu Arg Pro Ser Ser Asp Gln Glu Glu Gly 
        515                 520                 525             


Glu Thr Ser Ala Gln Thr Glu Arg Val Pro Leu Asp Leu Ser Pro Arg 
    530                 535                 540                 


Leu Glu Glu Thr Leu Asp Phe Gly Glu Val Glu Val Glu Pro Ser Glu 
545                 550                 555                 560 


Val Glu Asp Phe Glu Ala Arg Gly Ser Arg Phe Ser Lys Ser Ala Asp 
                565                 570                 575     


Glu Arg Gln Arg Met Leu Val Gln Arg Lys Asp Glu Leu Leu Gln Gln 
            580                 585                 590         


Ala Arg Lys Arg Phe Leu Asn Lys Ser Ser Glu Asp Asp Ala Ala Ser 
        595                 600                 605             


Glu Ser Phe Leu Pro Ser Glu Gly Ala Ser Ser Asp Pro Val Thr Leu 
    610                 615                 620                 


Arg Arg Arg Met Leu Ala Ala Ala Ala Glu Arg Arg Leu Gln Lys Gln 
625                 630                 635                 640 


Gln Thr Ser 
            


<210>  494
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH__Homo_sapiens__NP_000470

<400>  494

Met Arg Asp Leu Pro Leu Thr Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Thr Glu Ala Leu Arg Ala Glu Glu Pro Ala Val 
            20                  25                  30          


Gly Thr Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly 
        35                  40                  45              


Ser Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn 
    50                  55                  60                  


Gly Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu 
65                  70                  75                  80  


Gln Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp 
                85                  90                  95      


Leu Ala Thr Phe Gly Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu 
            100                 105                 110         


Pro Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln 
        115                 120                 125             


Arg Leu Val Val Leu His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro 
    130                 135                 140                 


Ser Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu 
145                 150                 155                 160 


Leu Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val 
                165                 170                 175     


Thr Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp 
            180                 185                 190         


Thr Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg 
        195                 200                 205             


Gly Ser Gly Leu Ala Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg 
    210                 215                 220                 


Leu Ser Thr Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg 
225                 230                 235                 240 


Cys Phe Thr Arg Met Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu 
                245                 250                 255     


Pro Ala Pro Leu Pro Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro 
            260                 265                 270         


Pro Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp 
        275                 280                 285             


Pro Phe Leu Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro 
    290                 295                 300                 


Pro Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu 
305                 310                 315                 320 


Ala Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu 
                325                 330                 335     


Glu Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro 
            340                 345                 350         


Thr Ala Ala Thr Thr Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser 
        355                 360                 365             


Ala Pro Trp Ala Thr Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln 
    370                 375                 380                 


Ala Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr 
385                 390                 395                 400 


Ala Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly 
                405                 410                 415     


Gly Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln 
            420                 425                 430         


Gly Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg 
        435                 440                 445             


Ala Gln Arg Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu 
    450                 455                 460                 


Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro 
465                 470                 475                 480 


Glu Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln 
                485                 490                 495     


Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys 
            500                 505                 510         


Met Gln Ala Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro 
        515                 520                 525             


Thr Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile 
    530                 535                 540                 


Ser Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 555                 560 


<210>  495
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMHR2__Homo_sapiens__NP_001158162

<400>  495

Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu 
1               5                   10                  15      


Ala Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val 
            20                  25                  30          


Arg Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu 
        35                  40                  45              


Leu Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile 
    50                  55                  60                  


Trp Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg 
65                  70                  75                  80  


Asp Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro 
                85                  90                  95      


Arg Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly 
            100                 105                 110         


Thr Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser 
    130                 135                 140                 


Ile Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg 
                165                 170                 175     


Val Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp 
            180                 185                 190         


Trp Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val 
        195                 200                 205             


Ile Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly 
    210                 215                 220                 


Lys Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His 
                245                 250                 255     


Ile Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu 
            260                 265                 270         


Ser Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys 
        275                 280                 285             


His Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met 
    290                 295                 300                 


Ala Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp 
305                 310                 315                 320 


Gln Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser 
                325                 330                 335     


Gln Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu 
            340                 345                 350         


Gly Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr 
        355                 360                 365             


Pro Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Thr Gln 
    370                 375                 380                 


Arg Tyr Met Ala Pro Glu Leu Leu Asp Lys Thr Leu Asp Leu Gln Asp 
385                 390                 395                 400 


Trp Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu 
                405                 410                 415     


Leu Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Ala Val His 
            420                 425                 430         


His Pro Ser Asn Trp Pro Met Arg Gln Asn Trp Ala Ile Pro Leu Pro 
        435                 440                 445             


Leu Met Ser Tyr Gly Pro Trp Gln Cys Arg Arg Gly Gly Val Pro Thr 
    450                 455                 460                 


Ser His Pro Pro Gly Ala Ala Leu Pro Gln Thr Leu Met Gly 
465                 470                 475             


<210>  496
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMICA1__Homo_sapiens__NP_001091996

<400>  496

Met Phe Cys Pro Leu Lys Leu Ile Leu Leu Pro Val Leu Leu Asp Tyr 
1               5                   10                  15      


Ser Leu Gly Leu Asn Asp Leu Asn Val Ser Pro Pro Glu Leu Thr Val 
            20                  25                  30          


His Val Gly Asp Ser Ala Leu Met Gly Cys Val Phe Gln Ser Thr Glu 
        35                  40                  45              


Asp Lys Cys Ile Phe Lys Ile Asp Trp Thr Leu Ser Pro Gly Glu His 
    50                  55                  60                  


Ala Lys Asp Glu Tyr Val Leu Tyr Tyr Tyr Ser Asn Leu Ser Val Pro 
65                  70                  75                  80  


Ile Gly Arg Phe Gln Asn Arg Val His Leu Met Gly Asp Ile Leu Cys 
                85                  90                  95      


Asn Asp Gly Ser Leu Leu Leu Gln Asp Val Gln Glu Ala Asp Gln Gly 
            100                 105                 110         


Thr Tyr Ile Cys Glu Ile Arg Leu Lys Gly Glu Ser Gln Val Phe Lys 
        115                 120                 125             


Lys Ala Val Val Leu His Val Leu Pro Glu Glu Pro Lys Glu Leu Met 
    130                 135                 140                 


Val His Val Gly Gly Leu Ile Gln Met Gly Cys Val Phe Gln Ser Thr 
145                 150                 155                 160 


Glu Val Lys His Val Thr Lys Val Glu Trp Ile Phe Ser Gly Arg Arg 
                165                 170                 175     


Ala Lys Glu Glu Ile Val Phe Arg Tyr Tyr His Lys Leu Arg Met Ser 
            180                 185                 190         


Val Glu Tyr Ser Gln Ser Trp Gly His Phe Gln Asn Arg Val Asn Leu 
        195                 200                 205             


Val Gly Asp Ile Phe Arg Asn Asp Gly Ser Ile Met Leu Gln Gly Val 
    210                 215                 220                 


Arg Glu Ser Asp Gly Gly Asn Tyr Thr Cys Ser Ile His Leu Gly Asn 
225                 230                 235                 240 


Leu Val Phe Lys Lys Thr Ile Val Leu His Val Ser Pro Glu Glu Pro 
                245                 250                 255     


Arg Thr Leu Val Thr Pro Ala Ala Leu Arg Pro Leu Val Leu Gly Gly 
            260                 265                 270         


Asn Gln Leu Val Ile Ile Val Gly Ile Val Cys Ala Thr Ile Leu Leu 
        275                 280                 285             


Leu Pro Val Leu Ile Leu Ile Val Lys Lys Thr Cys Gly Asn Lys Ser 
    290                 295                 300                 


Ser Val Asn Ser Thr Val Leu Val Lys Asn Thr Lys Lys Thr Asn Pro 
305                 310                 315                 320 


Glu Ile Lys Glu Lys Pro Cys His Phe Glu Arg Cys Glu Gly Glu Lys 
                325                 330                 335     


His Ile Tyr Ser Pro Ile Ile Val Arg Glu Val Ile Glu Glu Glu Glu 
            340                 345                 350         


Pro Ser Glu Lys Ser Glu Ala Thr Tyr Met Thr Met His Pro Val Trp 
        355                 360                 365             


Pro Ser Leu Arg Ser Asp Arg Asn Asn Ser Leu Glu Lys Lys Ser Gly 
    370                 375                 380                 


Gly Gly Met Pro Lys Thr Gln Gln Ala Phe 
385                 390                 


<210>  497
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMIGO2__Homo_sapiens__NP_862830

<400>  497

Met Ser Leu Arg Val His Thr Leu Pro Thr Leu Leu Gly Ala Val Val 
1               5                   10                  15      


Arg Pro Gly Cys Arg Glu Leu Leu Cys Leu Leu Met Ile Thr Val Thr 
            20                  25                  30          


Val Gly Pro Gly Ala Ser Gly Val Cys Pro Thr Ala Cys Ile Cys Ala 
        35                  40                  45              


Thr Asp Ile Val Ser Cys Thr Asn Lys Asn Leu Ser Lys Val Pro Gly 
    50                  55                  60                  


Asn Leu Phe Arg Leu Ile Lys Arg Leu Asp Leu Ser Tyr Asn Arg Ile 
65                  70                  75                  80  


Gly Leu Leu Asp Ser Glu Trp Ile Pro Val Ser Phe Ala Lys Leu Asn 
                85                  90                  95      


Thr Leu Ile Leu Arg His Asn Asn Ile Thr Ser Ile Ser Thr Gly Ser 
            100                 105                 110         


Phe Ser Thr Thr Pro Asn Leu Lys Cys Leu Asp Leu Ser Ser Asn Lys 
        115                 120                 125             


Leu Lys Thr Val Lys Asn Ala Val Phe Gln Glu Leu Lys Val Leu Glu 
    130                 135                 140                 


Val Leu Leu Leu Tyr Asn Asn His Ile Ser Tyr Leu Asp Pro Ser Ala 
145                 150                 155                 160 


Phe Gly Gly Leu Ser Gln Leu Gln Lys Leu Tyr Leu Ser Gly Asn Phe 
                165                 170                 175     


Leu Thr Gln Phe Pro Met Asp Leu Tyr Val Gly Arg Phe Lys Leu Ala 
            180                 185                 190         


Glu Leu Met Phe Leu Asp Val Ser Tyr Asn Arg Ile Pro Ser Met Pro 
        195                 200                 205             


Met His His Ile Asn Leu Val Pro Gly Lys Gln Leu Arg Gly Ile Tyr 
    210                 215                 220                 


Leu His Gly Asn Pro Phe Val Cys Asp Cys Ser Leu Tyr Ser Leu Leu 
225                 230                 235                 240 


Val Phe Trp Tyr Arg Arg His Phe Ser Ser Val Met Asp Phe Lys Asn 
                245                 250                 255     


Asp Tyr Thr Cys Arg Leu Trp Ser Asp Ser Arg His Ser Arg Gln Val 
            260                 265                 270         


Leu Leu Leu Gln Asp Ser Phe Met Asn Cys Ser Asp Ser Ile Ile Asn 
        275                 280                 285             


Gly Ser Phe Arg Ala Leu Gly Phe Ile His Glu Ala Gln Val Gly Glu 
    290                 295                 300                 


Arg Leu Met Val His Cys Asp Ser Lys Thr Gly Asn Ala Asn Thr Asp 
305                 310                 315                 320 


Phe Ile Trp Val Gly Pro Asp Asn Arg Leu Leu Glu Pro Asp Lys Glu 
                325                 330                 335     


Met Glu Asn Phe Tyr Val Phe His Asn Gly Ser Leu Val Ile Glu Ser 
            340                 345                 350         


Pro Arg Phe Glu Asp Ala Gly Val Tyr Ser Cys Ile Ala Met Asn Lys 
        355                 360                 365             


Gln Arg Leu Leu Asn Glu Thr Val Asp Val Thr Ile Asn Val Ser Asn 
    370                 375                 380                 


Phe Thr Val Ser Arg Ser His Ala His Glu Ala Phe Asn Thr Ala Phe 
385                 390                 395                 400 


Thr Thr Leu Ala Ala Cys Val Ala Ser Ile Val Leu Val Leu Leu Tyr 
                405                 410                 415     


Leu Tyr Leu Thr Pro Cys Pro Cys Lys Cys Lys Thr Lys Arg Gln Lys 
            420                 425                 430         


Asn Met Leu His Gln Ser Asn Ala His Ser Ser Ile Leu Ser Pro Gly 
        435                 440                 445             


Pro Ala Ser Asp Ala Ser Ala Asp Glu Arg Lys Ala Gly Ala Gly Lys 
    450                 455                 460                 


Arg Val Val Phe Leu Glu Pro Leu Lys Asp Thr Ala Ala Gly Gln Asn 
465                 470                 475                 480 


Gly Lys Val Arg Leu Phe Pro Ser Glu Ala Val Ile Ala Glu Gly Ile 
                485                 490                 495     


Leu Lys Ser Thr Arg Gly Lys Ser Asp Ser Asp Ser Val Asn Ser Val 
            500                 505                 510         


Phe Ser Asp Thr Pro Phe Val Ala Ser Thr 
        515                 520         


<210>  498
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMMECR1__Homo_sapiens__NP_001020751

<400>  498

Met Ala Ala Gly Cys Cys Gly Val Lys Lys Gln Lys Leu Ser Ser Ser 
1               5                   10                  15      


Pro Pro Ser Gly Ser Gly Gly Gly Gly Gly Ala Ser Ser Ser Ser His 
            20                  25                  30          


Cys Ser Gly Glu Ser Gln Cys Arg Ala Gly Glu Leu Gly Leu Gly Gly 
        35                  40                  45              


Ala Gly Thr Arg Leu Asn Gly Leu Gly Gly Leu Thr Gly Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Cys Thr Leu Ser Pro Pro Gln Gly Cys Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Ile Ala Leu Ser Pro Pro Pro Ser Cys Gly Val Gly Thr Leu 
                85                  90                  95      


Leu Ser Thr Pro Ala Ala Ala Thr Ser Ser Ser Pro Ser Ser Ser Ser 
            100                 105                 110         


Ala Ala Ser Ser Ser Ser Pro Gly Ser Arg Lys Met Val Val Ser Ala 
        115                 120                 125             


Glu Met Cys Cys Phe Cys Phe Asp Val Leu Tyr Cys His Leu Tyr Gly 
    130                 135                 140                 


Tyr Gln Gln Pro Arg Thr Pro Arg Phe Thr Asn Glu Pro Tyr Ala Leu 
145                 150                 155                 160 


Lys Asp Ser Arg Phe Pro Pro Met Thr Arg Asp Glu Leu Pro Arg Leu 
                165                 170                 175     


Phe Cys Ser Val Ser Leu Leu Thr Asn Phe Glu Asp Val Cys Asp Tyr 
            180                 185                 190         


Leu Asp Trp Glu Val Gly Val His Gly Ile Arg Ile Glu Phe Ile Asn 
        195                 200                 205             


Glu Lys Gly Ser Lys Arg Thr Ala Thr Tyr Leu Pro Glu Val Ala Lys 
    210                 215                 220                 


Glu Gln Gly Trp Asp His Ile Gln Thr Ile Asp Ser Leu Leu Arg Lys 
225                 230                 235                 240 


Gly Gly Tyr Lys Ala Pro Ile Thr Asn Glu Phe Arg Lys Thr Ile Lys 
                245                 250                 255     


Leu Thr Arg Tyr Arg Ser Glu Lys Met Thr Leu Ser Tyr Ala Glu Tyr 
            260                 265                 270         


Leu Ala His Arg Gln His His His Phe Gln Asn Gly Ile Gly His Pro 
        275                 280                 285             


Leu Pro Pro Tyr Asn His Tyr Ser 
    290                 295     


<210>  499
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMN__Homo_sapiens__NP_112205

<400>  499

Met Gly Val Leu Gly Arg Val Leu Leu Trp Leu Gln Leu Cys Ala Leu 
1               5                   10                  15      


Thr Gln Ala Val Ser Lys Leu Trp Val Pro Asn Thr Asp Phe Asp Val 
            20                  25                  30          


Ala Ala Asn Trp Ser Gln Asn Arg Thr Pro Cys Ala Gly Gly Ala Val 
        35                  40                  45              


Glu Phe Pro Ala Asp Lys Met Val Ser Val Leu Val Gln Glu Gly His 
    50                  55                  60                  


Ala Val Ser Asp Met Leu Leu Pro Leu Asp Gly Glu Leu Val Leu Ala 
65                  70                  75                  80  


Ser Gly Ala Gly Phe Gly Val Ser Asp Val Gly Ser His Leu Asp Cys 
                85                  90                  95      


Gly Ala Gly Glu Pro Ala Val Phe Arg Asp Ser Asp Arg Phe Ser Trp 
            100                 105                 110         


His Asp Pro His Leu Trp Arg Ser Gly Asp Glu Ala Pro Gly Leu Phe 
        115                 120                 125             


Phe Val Asp Ala Glu Arg Val Pro Cys Arg His Asp Asp Val Phe Phe 
    130                 135                 140                 


Pro Pro Ser Ala Ser Phe Arg Val Gly Leu Gly Pro Gly Ala Ser Pro 
145                 150                 155                 160 


Val Arg Val Arg Ser Ile Ser Ala Leu Gly Arg Thr Phe Thr Arg Asp 
                165                 170                 175     


Glu Asp Leu Ala Val Phe Leu Ala Ser Arg Ala Gly Arg Leu Arg Phe 
            180                 185                 190         


His Gly Pro Gly Ala Leu Ser Val Gly Pro Glu Asp Cys Ala Asp Pro 
        195                 200                 205             


Ser Gly Cys Val Cys Gly Asn Ala Glu Ala Gln Pro Trp Ile Cys Ala 
    210                 215                 220                 


Ala Leu Leu Gln Pro Leu Gly Gly Arg Cys Pro Gln Ala Ala Cys His 
225                 230                 235                 240 


Ser Ala Leu Arg Pro Gln Gly Gln Cys Cys Asp Leu Cys Gly Ala Val 
                245                 250                 255     


Val Leu Leu Thr His Gly Pro Ala Phe Asp Leu Glu Arg Tyr Arg Ala 
            260                 265                 270         


Arg Ile Leu Asp Thr Phe Leu Gly Leu Pro Gln Tyr His Gly Leu Gln 
        275                 280                 285             


Val Ala Val Ser Lys Val Pro Arg Ser Ser Arg Leu Arg Glu Ala Asp 
    290                 295                 300                 


Thr Glu Ile Gln Val Val Leu Val Glu Asn Gly Pro Glu Thr Gly Gly 
305                 310                 315                 320 


Ala Gly Arg Leu Ala Arg Ala Leu Leu Ala Asp Val Ala Glu Asn Gly 
                325                 330                 335     


Glu Ala Leu Gly Val Leu Glu Ala Thr Met Arg Glu Ser Gly Ala His 
            340                 345                 350         


Val Trp Gly Ser Ser Ala Ala Gly Leu Ala Gly Gly Val Ala Ala Ala 
        355                 360                 365             


Val Leu Leu Ala Leu Leu Val Leu Leu Val Ala Pro Pro Leu Leu Arg 
    370                 375                 380                 


Arg Ala Gly Arg Leu Arg Trp Arg Arg His Glu Ala Ala Ala Pro Ala 
385                 390                 395                 400 


Gly Ala Pro Leu Gly Phe Arg Asn Pro Val Phe Asp Val Thr Ala Ser 
                405                 410                 415     


Glu Glu Leu Pro Leu Pro Arg Arg Leu Ser Leu Val Pro Lys Ala Ala 
            420                 425                 430         


Ala Asp Ser Thr Ser His Ser Tyr Phe Val Asn Pro Leu Phe Ala Gly 
        435                 440                 445             


Ala Glu Ala Glu Ala 
    450             


<210>  500
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMOT__Homo_sapiens__XP_005262147

<400>  500

Met Pro Arg Ala Gln Pro Ser Ser Ala Ser Tyr Gln Pro Val Pro Ala 
1               5                   10                  15      


Asp Pro Phe Ala Ile Val Ser Arg Ala Gln Gln Met Val Glu Ile Leu 
            20                  25                  30          


Ser Asp Glu Asn Arg Asn Leu Arg Gln Glu Leu Glu Gly Cys Tyr Glu 
        35                  40                  45              


Lys Val Ala Arg Leu Gln Lys Val Glu Thr Glu Ile Gln Arg Val Ser 
    50                  55                  60                  


Glu Ala Tyr Glu Asn Leu Val Lys Ser Ser Ser Lys Arg Glu Ala Leu 
65                  70                  75                  80  


Glu Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Met His 
                85                  90                  95      


Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Thr Ala Asn Lys Gln 
            100                 105                 110         


Leu Ala Glu Lys Glu Tyr Glu Gly Ser Glu Asp Thr Arg Lys Thr Ile 
        115                 120                 125             


Ser Gln Leu Phe Ala Lys Asn Lys Glu Ser Gln Arg Glu Lys Glu Lys 
    130                 135                 140                 


Leu Glu Ala Glu Leu Ala Thr Ala Arg Ser Thr Asn Glu Asp Gln Arg 
145                 150                 155                 160 


Arg His Ile Glu Ile Arg Asp Gln Ala Leu Ser Asn Ala Gln Ala Lys 
                165                 170                 175     


Val Val Lys Leu Glu Glu Glu Leu Lys Lys Lys Gln Val Tyr Val Asp 
            180                 185                 190         


Lys Val Glu Lys Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala Cys 
        195                 200                 205             


Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Thr Arg Leu Glu Arg 
    210                 215                 220                 


Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln Pro 
225                 230                 235                 240 


Thr Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu Arg 
                245                 250                 255     


Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr Lys Trp 
            260                 265                 270         


Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala Leu Asp 
        275                 280                 285             


Ala Ala Ala Thr Val Ala Ala Gln Arg Asp Thr Thr Val Ile Ser His 
    290                 295                 300                 


Ser Pro Asn Thr Ser Tyr Asp Thr Ala Leu Glu Ala Arg Ile Gln Lys 
305                 310                 315                 320 


Glu Glu Glu Glu Ile Leu Met Ala Asn Lys Arg Cys Leu Asp Met Glu 
                325                 330                 335     


Gly Arg Ile Lys Thr Leu His Ala Gln Ile Ile Glu Lys Asp Ala Met 
            340                 345                 350         


Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys Thr Glu 
        355                 360                 365             


Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile Ser Asn 
    370                 375                 380                 


Ala Gly Ser Gly Leu Leu Ser His Ser Ser Thr Leu Thr Gly Ser Pro 
385                 390                 395                 400 


Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu Gly 
                405                 410                 415     


Ile Leu Leu Gly Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser Thr Pro 
            420                 425                 430         


Ser Pro Val Pro Pro Ser Thr Pro Leu Leu Ser Ala His Ser Lys Thr 
        435                 440                 445             


Gly Ser Arg Asp Cys Ser Thr Gln Thr Glu Arg Gly Thr Glu Ser Asn 
    450                 455                 460                 


Lys Thr Ala Ala Val Ala Pro Ile Ser Val Pro Ala Pro Val Ala Ala 
465                 470                 475                 480 


Ala Ala Thr Ala Ala Ala Ile Thr Ala Thr Ala Ala Thr Ile Thr Thr 
                485                 490                 495     


Thr Met Val Ala Ala Ala Pro Val Ala Val Ala Ala Ala Ala Ala Pro 
            500                 505                 510         


Ala Ala Ala Ala Ala Pro Ser Pro Ala Thr Ala Ala Ala Thr Ala Ala 
        515                 520                 525             


Ala Val Ser Pro Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala Ser Val 
    530                 535                 540                 


Ala Ser Ala Ala Ala Val Ala Pro Ser Ala Ala Ala Ala Ala Ala Val 
545                 550                 555                 560 


Gln Val Ala Pro Ala Ala Pro Ala Pro Val Pro Ala Pro Ala Leu Val 
                565                 570                 575     


Pro Val Pro Ala Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala Gln Thr 
            580                 585                 590         


Gln Ala Pro Thr Ser Ala Pro Ala Val Ala Pro Thr Pro Ala Pro Thr 
        595                 600                 605             


Pro Thr Pro Ala Val Ala Gln Ala Glu Val Pro Ala Ser Pro Ala Thr 
    610                 615                 620                 


Gly Pro Gly Pro His Arg Leu Ser Ile Pro Ser Leu Thr Cys Asn Pro 
625                 630                 635                 640 


Asp Lys Thr Asp Gly Pro Val Phe His Ser Asn Thr Leu Glu Arg Lys 
                645                 650                 655     


Thr Pro Ile Gln Ile Leu Gly Gln Glu Pro Asp Ala Glu Met Val Glu 
            660                 665                 670         


Tyr Leu Ile 
        675 


<210>  501
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMOTL1__Homo_sapiens__NP_001287936

<400>  501

Met Trp Arg Ala Lys Leu Arg Arg Gly Thr Cys Glu Pro Ala Val Lys 
1               5                   10                  15      


Val Glu Asp Pro Leu Cys Asn Phe His Ser Pro Asn Phe Leu Arg Ile 
            20                  25                  30          


Ser Glu Val Glu Met Arg Gly Ser Glu Asp Ala Ala Ala Gly Thr Val 
        35                  40                  45              


Leu Gln Arg Leu Ile Gln Glu Gln Leu Arg Tyr Gly Thr Pro Thr Glu 
    50                  55                  60                  


Asn Met Asn Leu Leu Ala Ile Gln His Gln Ala Thr Gly Ser Ala Gly 
65                  70                  75                  80  


Pro Ala His Pro Thr Asn Asn Phe Ser Ser Thr Glu Asn Leu Thr Gln 
                85                  90                  95      


Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro Gln Gly 
            100                 105                 110         


Gln Glu His Gln Val Asp Asn Thr Val Met Glu Lys Gln Val Arg Ser 
        115                 120                 125             


Thr Gln Pro Gln Gln Asn Asn Glu Glu Leu Pro Thr Tyr Glu Glu Ala 
    130                 135                 140                 


Lys Ala Gln Ser Gln Phe Phe Arg Gly Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gly Ala Val Gly His Gly Tyr Tyr Met Ala Gly Gly Thr Ser Gln 
                165                 170                 175     


Lys Ser Arg Thr Glu Gly Arg Pro Thr Val Asn Arg Ala Asn Ser Gly 
            180                 185                 190         


Gln Ala His Lys Asp Glu Ala Leu Lys Glu Leu Lys Gln Gly His Val 
        195                 200                 205             


Arg Ser Leu Ser Glu Arg Ile Met Gln Leu Ser Leu Glu Arg Asn Gly 
    210                 215                 220                 


Ala Lys Gln His Leu Pro Gly Ser Gly Asn Gly Lys Gly Phe Lys Val 
225                 230                 235                 240 


Gly Gly Gly Pro Ser Pro Ala Gln Pro Ala Gly Lys Val Leu Asp Pro 
                245                 250                 255     


Arg Gly Pro Pro Pro Glu Tyr Pro Phe Lys Thr Lys Gln Met Met Ser 
            260                 265                 270         


Pro Val Ser Lys Thr Gln Glu His Gly Leu Phe Tyr Gly Asp Gln His 
        275                 280                 285             


Pro Gly Met Leu His Glu Met Val Lys Pro Tyr Pro Ala Pro Gln Pro 
    290                 295                 300                 


Val Arg Thr Asp Val Ala Val Leu Arg Tyr Gln Pro Pro Pro Glu Tyr 
305                 310                 315                 320 


Gly Val Thr Ser Arg Pro Cys Gln Leu Pro Phe Pro Ser Thr Met Gln 
                325                 330                 335     


Gln His Ser Pro Met Ser Ser Gln Thr Ser Ser Ala Ser Gly Pro Leu 
            340                 345                 350         


His Ser Val Ser Leu Pro Leu Pro Leu Pro Met Ala Leu Gly Ala Pro 
        355                 360                 365             


Gln Pro Pro Pro Ala Ala Ser Pro Ser Gln Gln Leu Gly Pro Asp Ala 
    370                 375                 380                 


Phe Ala Ile Val Glu Arg Ala Gln Gln Met Val Glu Ile Leu Thr Glu 
385                 390                 395                 400 


Glu Asn Arg Val Leu His Gln Glu Leu Gln Gly Tyr Tyr Asp Asn Ala 
                405                 410                 415     


Asp Lys Leu His Lys Phe Glu Lys Glu Leu Gln Arg Ile Ser Glu Ala 
            420                 425                 430         


Tyr Glu Ser Leu Val Lys Ser Thr Thr Lys Arg Glu Ser Leu Asp Lys 
        435                 440                 445             


Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Leu His Asp Phe 
    450                 455                 460                 


Asn Arg Asp Leu Arg Asp Arg Leu Glu Thr Ala Asn Arg Gln Leu Ser 
465                 470                 475                 480 


Ser Arg Glu Tyr Glu Gly His Glu Asp Lys Ala Ala Glu Gly His Tyr 
                485                 490                 495     


Ala Ser Gln Asn Lys Glu Phe Leu Lys Glu Lys Glu Lys Leu Glu Met 
            500                 505                 510         


Glu Leu Ala Ala Val Arg Thr Ala Ser Glu Asp His Arg Arg His Ile 
        515                 520                 525             


Glu Ile Leu Asp Gln Ala Leu Ser Asn Ala Gln Ala Arg Val Ile Lys 
    530                 535                 540                 


Leu Glu Glu Glu Leu Arg Glu Lys Gln Ala Tyr Val Glu Lys Val Glu 
545                 550                 555                 560 


Lys Leu Gln Gln Ala Leu Thr Gln Leu Gln Ser Ala Cys Glu Lys Arg 
                565                 570                 575     


Glu Gln Met Glu Arg Arg Leu Arg Thr Trp Leu Glu Arg Glu Leu Asp 
            580                 585                 590         


Ala Leu Arg Thr Gln Gln Lys His Gly Asn Gly Gln Pro Ala Asn Met 
        595                 600                 605             


Pro Glu Tyr Asn Ala Pro Ala Leu Leu Glu Leu Val Arg Glu Lys Glu 
    610                 615                 620                 


Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys 
625                 630                 635                 640 


Tyr Leu Glu Glu Ser Thr Ile Arg His Phe Ala Met Asn Ala Ala Ala 
                645                 650                 655     


Thr Ala Ala Ala Glu Arg Asp Thr Thr Ile Ile Asn His Ser Arg Asn 
            660                 665                 670         


Gly Ser Tyr Gly Glu Ser Ser Leu Glu Ala His Ile Trp Gln Glu Glu 
        675                 680                 685             


Glu Glu Val Val Gln Ala Asn Arg Arg Cys Gln Asp Met Glu Tyr Thr 
    690                 695                 700                 


Ile Lys Asn Leu His Ala Lys Ile Ile Glu Lys Asp Ala Met Ile Lys 
705                 710                 715                 720 


Val Leu Gln Gln Arg Ser Arg Lys Asp Ala Gly Lys Thr Asp Ser Ser 
                725                 730                 735     


Ser Leu Arg Pro Ala Arg Ser Val Pro Ser Ile Ala Ala Ala Thr Gly 
            740                 745                 750         


Thr His Ser Arg Gln Thr Ser Leu Thr Ser Ser Gln Leu Ala Glu Glu 
        755                 760                 765             


Lys Lys Glu Glu Lys Thr Trp Lys Gly Ser Ile Gly Leu Leu Leu Gly 
    770                 775                 780                 


Lys Glu His His Glu His Ala Ser Ala Pro Leu Leu Pro Pro Pro Pro 
785                 790                 795                 800 


Thr Ser Ala Leu Ser Ser Ile Ala Ser Thr Thr Ala Ala Ser Ser Ala 
                805                 810                 815     


His Ala Lys Thr Gly Ser Lys Asp Ser Ser Thr Gln Thr Asp Lys Ser 
            820                 825                 830         


Ala Glu Leu Phe Trp Pro Ser Met Ala Ser Leu Pro Ser Arg Gly Arg 
        835                 840                 845             


Leu Ser Thr Thr Pro Ala His Ser Pro Val Leu Lys His Pro Ala Ala 
    850                 855                 860                 


Lys Gly Thr Ala Glu Lys Leu Glu Asn Ser Pro Gly His Gly Lys Ser 
865                 870                 875                 880 


Pro Asp His Arg Gly Arg Val Ser Ser Leu Leu His Lys Pro Glu Phe 
                885                 890                 895     


Pro Asp Gly Glu Met Met Glu Val Leu Ile 
            900                 905     


<210>  502
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMPD2__Homo_sapiens__XP_011539550

<400>  502

Met Arg Lys Leu Thr His Gly Thr Gly Pro Arg Pro Arg Val Gly Ser 
1               5                   10                  15      


Gly Gln Pro Tyr Arg Gly Val Val Ala Ala His Val Ala Pro Arg Lys 
            20                  25                  30          


Arg Lys Lys Trp Arg Gly Gly Val Gly Arg Arg Arg Arg Gly Gln Ala 
        35                  40                  45              


Gly Ala Gly Pro Arg Ala Ala Glu Pro Gly Ala Glu Pro Ala Arg Phe 
    50                  55                  60                  


Trp Trp Gly Leu Thr Cys Cys Val Thr Pro Pro Gln Ser Gly Arg Gly 
65                  70                  75                  80  


Ser Pro Thr Leu Asn Ala Gln Gly Val Leu Arg Glu Ile Trp Thr Ser 
                85                  90                  95      


Phe Gly Ser Arg Ser Leu Gly Ser Thr Trp Pro Thr Ser Leu Ser Ile 
            100                 105                 110         


Ala Gly Leu Gly Gly Arg Asp Thr Gly Val Ala Leu Arg Pro Val Arg 
        115                 120                 125             


Leu Pro Arg Ser Ala Gly Val His Leu Arg Pro Ala Gly Asn Phe Glu 
    130                 135                 140                 


Arg Leu Pro Tyr Phe Pro His Leu Ser Ala Arg Ala Gly Ala Leu Gly 
145                 150                 155                 160 


Val Thr Trp Leu Gly Ser Val Ala Arg Ser Pro Cys Arg Pro Ser Gly 
                165                 170                 175     


Pro Gly Leu Ser Ala Val Gln Thr Ser Arg Gly Gln Pro Pro Leu Gly 
            180                 185                 190         


Thr Arg Ala Ser Trp Pro Gln Glu Leu Phe Thr Arg Ser Leu Ala Glu 
        195                 200                 205             


Ser Glu Leu Arg Ser Ala Pro Tyr Glu Phe Pro Glu Glu Ser Pro Ile 
    210                 215                 220                 


Glu Gln Leu Glu Glu Arg Arg Gln Arg Leu Glu Arg Gln Ile Ser Gln 
225                 230                 235                 240 


Asp Val Lys Leu Glu Pro Asp Ile Leu Leu Arg Ala Lys Gln Asp Phe 
                245                 250                 255     


Leu Lys Thr Asp Ser Asp Ser Asp Leu Gln Leu Tyr Lys Glu Gln Gly 
            260                 265                 270         


Glu Gly Gln Gly Asp Arg Ser Leu Arg Glu Arg Asp Val Leu Glu Arg 
        275                 280                 285             


Glu Phe Gln Arg Val Thr Ile Ser Gly Glu Glu Lys Cys Gly Val Pro 
    290                 295                 300                 


Phe Thr Asp Leu Leu Asp Ala Ala Lys Ser Val Val Arg Ala Leu Phe 
305                 310                 315                 320 


Ile Arg Glu Lys Tyr Met Ala Leu Ser Leu Gln Ser Phe Cys Pro Thr 
                325                 330                 335     


Thr Arg Arg Tyr Leu Gln Gln Leu Ala Glu Lys Pro Leu Glu Thr Arg 
            340                 345                 350         


Thr Tyr Glu Gln Gly Pro Asp Thr Pro Val Ser Ala Asp Ala Pro Val 
        355                 360                 365             


His Pro Pro Ala Leu Glu Gln His Pro Tyr Glu His Cys Glu Pro Ser 
    370                 375                 380                 


Thr Met Pro Gly Asp Leu Gly Leu Gly Leu Arg Met Val Arg Gly Val 
385                 390                 395                 400 


Val His Val Tyr Thr Arg Arg Glu Pro Asp Glu His Cys Ser Glu Val 
                405                 410                 415     


Glu Leu Pro Tyr Pro Asp Leu Gln Glu Phe Val Ala Asp Val Asn Val 
            420                 425                 430         


Leu Met Ala Leu Ile Ile Asn Gly Pro Ile Lys Ser Phe Cys Tyr Arg 
        435                 440                 445             


Arg Leu Gln Tyr Leu Ser Ser Lys Phe Gln Met His Val Leu Leu Asn 
    450                 455                 460                 


Glu Met Lys Glu Leu Ala Ala Gln Lys Lys Val Pro His Arg Asp Phe 
465                 470                 475                 480 


Tyr Asn Ile Arg Lys Val Asp Thr His Ile His Ala Ser Ser Cys Met 
                485                 490                 495     


Asn Gln Lys His Leu Leu Arg Phe Ile Lys Arg Ala Met Lys Arg His 
            500                 505                 510         


Leu Glu Glu Ile Val His Val Glu Gln Gly Arg Glu Gln Thr Leu Arg 
        515                 520                 525             


Glu Val Phe Glu Ser Met Asn Leu Thr Ala Tyr Asp Leu Ser Val Asp 
    530                 535                 540                 


Thr Leu Asp Val His Ala Asp Arg Asn Thr Phe His Arg Phe Asp Lys 
545                 550                 555                 560 


Phe Asn Ala Lys Tyr Asn Pro Ile Gly Glu Ser Val Leu Arg Glu Ile 
                565                 570                 575     


Phe Ile Lys Thr Asp Asn Arg Val Ser Gly Lys Tyr Phe Ala His Ile 
            580                 585                 590         


Ile Lys 
        


<210>  503
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMPD3__Homo_sapiens__NP_000471

<400>  503

Met Ala Leu Ser Ser Glu Pro Ala Glu Met Pro Arg Gln Phe Pro Lys 
1               5                   10                  15      


Leu Asn Ile Ser Glu Val Asp Glu Gln Val Arg Leu Leu Ala Glu Lys 
            20                  25                  30          


Val Phe Ala Lys Val Leu Arg Glu Glu Asp Ser Lys Asp Ala Leu Ser 
        35                  40                  45              


Leu Phe Thr Val Pro Glu Asp Cys Pro Ile Gly Gln Lys Glu Ala Lys 
    50                  55                  60                  


Glu Arg Glu Leu Gln Lys Glu Leu Ala Glu Gln Lys Ser Val Glu Thr 
65                  70                  75                  80  


Ala Lys Arg Lys Lys Ser Phe Lys Met Ile Arg Ser Gln Ser Leu Ser 
                85                  90                  95      


Leu Gln Met Pro Pro Gln Gln Asp Trp Lys Gly Pro Pro Ala Ala Ser 
            100                 105                 110         


Pro Ala Met Ser Pro Thr Thr Pro Val Val Thr Gly Ala Thr Ser Leu 
        115                 120                 125             


Pro Thr Pro Ala Pro Tyr Ala Met Pro Glu Phe Gln Arg Val Thr Ile 
    130                 135                 140                 


Ser Gly Asp Tyr Cys Ala Gly Ile Thr Leu Glu Asp Tyr Glu Gln Ala 
145                 150                 155                 160 


Ala Lys Ser Leu Ala Lys Ala Leu Met Ile Arg Glu Lys Tyr Ala Arg 
                165                 170                 175     


Leu Ala Tyr His Arg Phe Pro Arg Ile Thr Ser Gln Tyr Leu Gly His 
            180                 185                 190         


Pro Arg Ala Asp Thr Ala Pro Pro Glu Glu Gly Leu Pro Asp Phe His 
        195                 200                 205             


Pro Pro Pro Leu Pro Gln Glu Asp Pro Tyr Cys Leu Asp Asp Ala Pro 
    210                 215                 220                 


Pro Asn Leu Asp Tyr Leu Val His Met Gln Gly Gly Ile Leu Phe Val 
225                 230                 235                 240 


Tyr Asp Asn Lys Lys Met Leu Glu His Gln Glu Pro His Ser Leu Pro 
                245                 250                 255     


Tyr Pro Asp Leu Glu Thr Tyr Thr Val Asp Met Ser His Ile Leu Ala 
            260                 265                 270         


Leu Ile Thr Asp Gly Pro Thr Lys Thr Tyr Cys His Arg Arg Leu Asn 
        275                 280                 285             


Phe Leu Glu Ser Lys Phe Ser Leu His Glu Met Leu Asn Glu Met Ser 
    290                 295                 300                 


Glu Phe Lys Glu Leu Lys Ser Asn Pro His Arg Asp Phe Tyr Asn Val 
305                 310                 315                 320 


Arg Lys Val Asp Thr His Ile His Ala Ala Ala Cys Met Asn Gln Lys 
                325                 330                 335     


His Leu Leu Arg Phe Ile Lys His Thr Tyr Gln Thr Glu Pro Asp Arg 
            340                 345                 350         


Thr Val Ala Glu Lys Arg Gly Arg Lys Ile Thr Leu Arg Gln Val Phe 
        355                 360                 365             


Asp Gly Leu His Met Asp Pro Tyr Asp Leu Thr Val Asp Ser Leu Asp 
    370                 375                 380                 


Val His Ala Gly Arg Gln Thr Phe His Arg Phe Asp Lys Phe Asn Ser 
385                 390                 395                 400 


Lys Tyr Asn Pro Val Gly Ala Ser Glu Leu Arg Asp Leu Tyr Leu Lys 
                405                 410                 415     


Thr Glu Asn Tyr Leu Gly Gly Glu Tyr Phe Ala Arg Met Val Lys Glu 
            420                 425                 430         


Val Ala Arg Glu Leu Glu Glu Ser Lys Tyr Gln Tyr Ser Glu Pro Arg 
        435                 440                 445             


Leu Ser Ile Tyr Gly Arg Ser Pro Glu Glu Trp Pro Asn Leu Ala Tyr 
    450                 455                 460                 


Trp Phe Ile Gln His Lys Val Tyr Ser Pro Asn Met Arg Trp Ile Ile 
465                 470                 475                 480 


Gln Val Pro Arg Ile Tyr Asp Ile Phe Arg Ser Lys Lys Leu Leu Pro 
                485                 490                 495     


Asn Phe Gly Lys Met Leu Glu Asn Ile Phe Leu Pro Leu Phe Lys Ala 
            500                 505                 510         


Thr Ile Asn Pro Gln Asp His Arg Glu Leu His Leu Phe Leu Lys Tyr 
        515                 520                 525             


Val Thr Gly Phe Asp Ser Val Asp Asp Glu Ser Lys His Ser Asp His 
    530                 535                 540                 


Met Phe Ser Asp Lys Ser Pro Asn Pro Asp Val Trp Thr Ser Glu Gln 
545                 550                 555                 560 


Asn Pro Pro Tyr Ser Tyr Tyr Leu Tyr Tyr Met Tyr Ala Asn Ile Met 
                565                 570                 575     


Val Leu Asn Asn Leu Arg Arg Glu Arg Gly Leu Ser Thr Phe Leu Phe 
            580                 585                 590         


Arg Pro His Cys Gly Glu Ala Gly Ser Ile Thr His Leu Val Ser Ala 
        595                 600                 605             


Phe Leu Thr Ala Asp Asn Ile Ser His Gly Leu Leu Leu Lys Lys Ser 
    610                 615                 620                 


Pro Val Leu Gln Tyr Leu Tyr Tyr Leu Ala Gln Ile Pro Ile Ala Met 
625                 630                 635                 640 


Ser Pro Leu Ser Asn Asn Ser Leu Phe Leu Glu Tyr Ser Lys Asn Pro 
                645                 650                 655     


Leu Arg Glu Phe Leu His Lys Gly Leu His Val Ser Leu Ser Thr Asp 
            660                 665                 670         


Asp Pro Met Gln Phe His Tyr Thr Lys Glu Ala Leu Met Glu Glu Tyr 
        675                 680                 685             


Ala Ile Ala Ala Gln Val Trp Lys Leu Ser Thr Cys Asp Leu Cys Glu 
    690                 695                 700                 


Ile Ala Arg Asn Ser Val Leu Gln Ser Gly Leu Ser His Gln Glu Lys 
705                 710                 715                 720 


Gln Lys Phe Leu Gly Gln Asn Tyr Tyr Lys Glu Gly Pro Glu Gly Asn 
                725                 730                 735     


Asp Ile Arg Lys Thr Asn Val Ala Gln Ile Arg Met Ala Phe Arg Tyr 
            740                 745                 750         


Glu Thr Leu Cys Asn Glu Leu Ser Phe Leu Ser Asp Ala Met Lys Ser 
        755                 760                 765             


Glu Glu Ile Thr Ala Leu Thr Asn 
    770                 775     


<210>  504
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMPH__Homo_sapiens__NP_001626

<400>  504

Met Ala Asp Ile Lys Thr Gly Ile Phe Ala Lys Asn Val Gln Lys Arg 
1               5                   10                  15      


Leu Asn Arg Ala Gln Glu Lys Val Leu Gln Lys Leu Gly Lys Ala Asp 
            20                  25                  30          


Glu Thr Lys Asp Glu Gln Phe Glu Glu Tyr Val Gln Asn Phe Lys Arg 
        35                  40                  45              


Gln Glu Ala Glu Gly Thr Arg Leu Gln Arg Glu Leu Arg Gly Tyr Leu 
    50                  55                  60                  


Ala Ala Ile Lys Gly Met Gln Glu Ala Ser Met Lys Leu Thr Glu Ser 
65                  70                  75                  80  


Leu His Glu Val Tyr Glu Pro Asp Trp Tyr Gly Arg Glu Asp Val Lys 
                85                  90                  95      


Met Val Gly Glu Lys Cys Asp Val Leu Trp Glu Asp Phe His Gln Lys 
            100                 105                 110         


Leu Val Asp Gly Ser Leu Leu Thr Leu Asp Thr Tyr Leu Gly Gln Phe 
        115                 120                 125             


Pro Asp Ile Lys Asn Arg Ile Ala Lys Arg Ser Arg Lys Leu Val Asp 
    130                 135                 140                 


Tyr Asp Ser Ala Arg His His Leu Glu Ala Leu Gln Ser Ser Lys Arg 
145                 150                 155                 160 


Lys Asp Glu Ser Arg Ile Ser Lys Ala Glu Glu Glu Phe Gln Lys Ala 
                165                 170                 175     


Gln Lys Val Phe Glu Glu Phe Asn Val Asp Leu Gln Glu Glu Leu Pro 
            180                 185                 190         


Ser Leu Trp Ser Arg Arg Val Gly Phe Tyr Val Asn Thr Phe Lys Asn 
        195                 200                 205             


Val Ser Ser Leu Glu Ala Lys Phe His Lys Glu Ile Ala Val Leu Cys 
    210                 215                 220                 


His Lys Leu Tyr Glu Val Met Thr Lys Leu Gly Asp Gln His Ala Asp 
225                 230                 235                 240 


Lys Ala Phe Thr Ile Gln Gly Ala Pro Ser Asp Ser Gly Pro Leu Arg 
                245                 250                 255     


Ile Ala Lys Thr Pro Ser Pro Pro Glu Glu Pro Ser Pro Leu Pro Ser 
            260                 265                 270         


Pro Thr Ala Ser Pro Asn His Thr Leu Ala Pro Ala Ser Pro Ala Pro 
        275                 280                 285             


Ala Arg Pro Arg Ser Pro Ser Gln Thr Arg Lys Gly Pro Pro Val Pro 
    290                 295                 300                 


Pro Leu Pro Lys Val Thr Pro Thr Lys Glu Leu Gln Gln Glu Asn Ile 
305                 310                 315                 320 


Ile Ser Phe Phe Glu Asp Asn Phe Val Pro Glu Ile Ser Val Thr Thr 
                325                 330                 335     


Pro Ser Gln Asn Glu Val Pro Glu Val Lys Lys Glu Glu Thr Leu Leu 
            340                 345                 350         


Asp Leu Asp Phe Asp Pro Phe Lys Pro Glu Val Thr Pro Ala Gly Ser 
        355                 360                 365             


Ala Gly Val Thr His Ser Pro Met Ser Gln Thr Leu Pro Trp Asp Leu 
    370                 375                 380                 


Trp Thr Thr Ser Thr Asp Leu Val Gln Pro Ala Ser Gly Gly Ser Phe 
385                 390                 395                 400 


Asn Gly Phe Thr Gln Pro Gln Asp Thr Ser Leu Phe Thr Met Gln Thr 
                405                 410                 415     


Asp Gln Ser Met Ile Cys Asn Leu Ala Glu Ser Glu Gln Ala Pro Pro 
            420                 425                 430         


Thr Glu Pro Lys Ala Glu Glu Pro Leu Ala Ala Val Thr Pro Ala Val 
        435                 440                 445             


Gly Leu Asp Leu Gly Met Asp Thr Arg Ala Glu Glu Pro Val Glu Glu 
    450                 455                 460                 


Ala Val Ile Ile Pro Gly Ala Asp Ala Asp Ala Ala Val Gly Thr Leu 
465                 470                 475                 480 


Val Ser Ala Ala Glu Gly Ala Pro Gly Glu Glu Ala Glu Ala Glu Lys 
                485                 490                 495     


Ala Thr Val Pro Ala Gly Glu Gly Val Ser Leu Glu Glu Ala Lys Ile 
            500                 505                 510         


Gly Thr Glu Thr Thr Glu Gly Ala Glu Ser Ala Gln Pro Glu Ala Glu 
        515                 520                 525             


Glu Leu Glu Ala Thr Val Pro Gln Glu Lys Val Ile Pro Ser Val Val 
    530                 535                 540                 


Ile Glu Pro Ala Ser Asn His Glu Glu Glu Gly Glu Asn Glu Ile Thr 
545                 550                 555                 560 


Ile Gly Ala Glu Pro Lys Glu Thr Thr Glu Asp Ala Ala Pro Pro Gly 
                565                 570                 575     


Pro Thr Ser Glu Thr Pro Glu Leu Ala Thr Glu Gln Lys Pro Ile Gln 
            580                 585                 590         


Asp Pro Gln Pro Thr Pro Ser Ala Pro Ala Met Gly Ala Ala Asp Gln 
        595                 600                 605             


Leu Ala Ser Ala Arg Glu Ala Ser Gln Glu Leu Pro Pro Gly Phe Leu 
    610                 615                 620                 


Tyr Lys Val Glu Thr Leu His Asp Phe Glu Ala Ala Asn Ser Asp Glu 
625                 630                 635                 640 


Leu Thr Leu Gln Arg Gly Asp Val Val Leu Val Val Pro Ser Asp Ser 
                645                 650                 655     


Glu Ala Asp Gln Asp Ala Gly Trp Leu Val Gly Val Lys Glu Ser Asp 
            660                 665                 670         


Trp Leu Gln Tyr Arg Asp Leu Ala Thr Tyr Lys Gly Leu Phe Pro Glu 
        675                 680                 685             


Asn Phe Thr Arg Arg Leu Asp 
    690                 695 


<210>  505
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMT__Homo_sapiens__NP_000472

<400>  505

Met Gln Arg Ala Val Ser Val Val Ala Arg Leu Gly Phe Arg Leu Gln 
1               5                   10                  15      


Ala Phe Pro Pro Ala Leu Cys Arg Pro Leu Ser Cys Ala Gln Glu Val 
            20                  25                  30          


Leu Arg Arg Thr Pro Leu Tyr Asp Phe His Leu Ala His Gly Gly Lys 
        35                  40                  45              


Met Val Ala Phe Ala Gly Trp Ser Leu Pro Val Gln Tyr Arg Asp Ser 
    50                  55                  60                  


His Thr Asp Ser His Leu His Thr Arg Gln His Cys Ser Leu Phe Asp 
65                  70                  75                  80  


Val Ser His Met Leu Gln Thr Lys Ile Leu Gly Ser Asp Arg Val Lys 
                85                  90                  95      


Leu Met Glu Ser Leu Val Val Gly Asp Ile Ala Glu Leu Arg Pro Asn 
            100                 105                 110         


Gln Gly Thr Leu Ser Leu Phe Thr Asn Glu Ala Gly Gly Ile Leu Asp 
        115                 120                 125             


Asp Leu Ile Val Thr Asn Thr Ser Glu Gly His Leu Tyr Val Val Ser 
    130                 135                 140                 


Asn Ala Gly Cys Trp Glu Lys Asp Leu Ala Leu Met Gln Asp Lys Val 
145                 150                 155                 160 


Arg Glu Leu Gln Asn Gln Gly Arg Asp Val Gly Leu Glu Val Leu Asp 
                165                 170                 175     


Asn Ala Leu Leu Ala Leu Gln Gly Pro Thr Ala Ala Gln Val Leu Gln 
            180                 185                 190         


Ala Gly Val Ala Asp Asp Leu Arg Lys Leu Pro Phe Met Thr Ser Ala 
        195                 200                 205             


Val Met Glu Val Phe Gly Val Ser Gly Cys Arg Val Thr Arg Cys Gly 
    210                 215                 220                 


Tyr Thr Gly Glu Asp Gly Val Glu Ile Ser Val Pro Val Ala Gly Ala 
225                 230                 235                 240 


Val His Leu Ala Thr Ala Ile Leu Lys Asn Pro Glu Val Lys Leu Ala 
                245                 250                 255     


Gly Leu Ala Ala Arg Asp Ser Leu Arg Leu Glu Ala Gly Leu Cys Leu 
            260                 265                 270         


Tyr Gly Asn Asp Ile Asp Glu His Thr Thr Pro Val Glu Gly Ser Leu 
        275                 280                 285             


Ser Trp Thr Leu Gly Lys Arg Arg Arg Ala Ala Met Asp Phe Pro Gly 
    290                 295                 300                 


Ala Lys Val Ile Val Pro Gln Leu Lys Gly Arg Val Gln Arg Arg Arg 
305                 310                 315                 320 


Val Gly Leu Met Cys Glu Gly Ala Pro Met Arg Ala His Ser Pro Ile 
                325                 330                 335     


Leu Asn Met Glu Gly Thr Lys Ile Gly Thr Val Thr Ser Gly Cys Pro 
            340                 345                 350         


Ser Pro Ser Leu Lys Lys Asn Val Ala Met Gly Tyr Val Pro Cys Glu 
        355                 360                 365             


Tyr Ser Arg Pro Gly Thr Met Leu Leu Val Glu Val Arg Arg Lys Gln 
    370                 375                 380                 


Gln Met Ala Val Val Ser Lys Met Pro Phe Val Pro Thr Asn Tyr Tyr 
385                 390                 395                 400 


Thr Leu Lys 
            


<210>  506
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMZ1__Homo_sapiens__XP_011513452

<400>  506

Met Leu Gln Cys Arg Pro Ala Gln Glu Phe Ser Phe Gly Pro Arg Ala 
1               5                   10                  15      


Leu Lys Asp Ala Leu Val Ser Thr Asp Ala Ala Leu Gln Gln Leu Tyr 
            20                  25                  30          


Val Ser Ala Phe Ser Pro Ala Glu Arg Leu Phe Leu Ala Glu Ala Tyr 
        35                  40                  45              


Asn Pro Gln Arg Thr Leu Phe Cys Thr Leu Leu Ile Arg Thr Gly Phe 
    50                  55                  60                  


Asp Trp Leu Leu Ser Arg Pro Glu Ala Pro Glu Asp Phe Gln Thr Phe 
65                  70                  75                  80  


His Ala Ser Leu Gln His Arg Lys Pro Arg Leu Ala Arg Lys His Ile 
                85                  90                  95      


Tyr Leu Gln Pro Ile Asp Leu Ser Glu Glu Pro Val Gly Ser Ser Leu 
            100                 105                 110         


Leu His Gln Leu Cys Ser Cys Thr Glu Ala Phe Phe Leu Gly Leu Arg 
        115                 120                 125             


Val Lys Cys Leu Pro Ser Val Ala Ala Ala Ser Ile Arg Cys Ser Ser 
    130                 135                 140                 


Arg Pro Ser Arg Asp Ser Asp Arg Leu Gln Leu His Thr Asp Gly Ile 
145                 150                 155                 160 


Leu Ser Phe Leu Lys Asn Asn Lys Pro Gly Asp Ala Leu Cys Val Leu 
                165                 170                 175     


Gly Leu Thr Leu Ser Asp Leu Tyr Pro His Glu Ala Trp Ser Phe Thr 
            180                 185                 190         


Phe Ser Lys Phe Leu Pro Gly His Glu Val Gly Val Cys Ser Phe Ala 
        195                 200                 205             


Arg Phe Ser Gly Glu Phe Pro Lys Ser Gly Pro Ser Ala Pro Asp Leu 
    210                 215                 220                 


Ala Leu Val Glu Ala Ala Ala Asp Gly Pro Glu Ala Pro Leu Gln Asp 
225                 230                 235                 240 


Arg Gly Trp Ala Leu Cys Phe Ser Ala Leu Gly Met Val Gln Cys Cys 
                245                 250                 255     


Lys Val Thr Cys His Glu Leu Cys His Leu Leu Gly Leu Gly Asn Cys 
            260                 265                 270         


Arg Trp Leu Arg Cys Leu Met Gln Gly Ala Leu Ser Leu Asp Glu Ala 
        275                 280                 285             


Leu Arg Arg Pro Leu Asp Leu Cys Pro Ile Cys Leu Arg Lys Leu Gln 
    290                 295                 300                 


His Val Leu Gly Phe Arg Leu Ile Glu Arg Tyr Gln Arg Leu Tyr Thr 
305                 310                 315                 320 


Trp Thr Gln Ala Val Val Gly Thr Trp Pro Ser Gln Glu Ala Gly Glu 
                325                 330                 335     


Pro Ser Val Trp Glu Asp Thr Pro Pro Ala Ser Ala Asp Ser Gly Met 
            340                 345                 350         


Cys Cys Glu Ser Asp Ser Glu Pro Gly Thr Ser Val Ser Glu Pro Leu 
        355                 360                 365             


Thr Pro Asp Ala Gly Ser His Thr Phe Ala Ser Gly Pro Glu Glu Gly 
    370                 375                 380                 


Leu Ser Tyr Leu Ala Ala Ser Glu Ala Pro Leu Pro Pro Gly Gly Pro 
385                 390                 395                 400 


Ala Glu Ala Ile Lys Glu His Glu Arg Trp Leu Ala Met Cys Ile Gln 
                405                 410                 415     


Ala Leu Gln Arg Glu Val Ala Glu Glu Asp Leu Val Gln Val Asp Arg 
            420                 425                 430         


Ala Val Asp Ala Leu Asp Arg Trp Glu Met Phe Thr Gly Gln Leu Pro 
        435                 440                 445             


Ala Thr Arg Gln Asp Pro Pro Ser Ser Arg Asp Ser Val Gly Leu Arg 
    450                 455                 460                 


Lys Val Leu Gly Asp Lys Phe Ser Ser Leu Arg Arg Lys Leu Ser Ala 
465                 470                 475                 480 


Arg Lys Leu Ala Arg Ala Glu Ser Ala Pro Arg Pro Trp Asp Gly Glu 
                485                 490                 495     


Glu Ser 
        


<210>  507
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC10__Homo_sapiens__NP_001243638

<400>  507

Met Gly Gly Val Lys Glu Thr Asn Ile Leu Lys Met Thr Thr Pro Asn 
1               5                   10                  15      


Lys Thr Pro Pro Gly Ala Asp Pro Lys Gln Leu Glu Arg Thr Gly Thr 
            20                  25                  30          


Val Arg Glu Ile Gly Ser Gln Ala Val Trp Ser Leu Ser Ser Cys Lys 
        35                  40                  45              


Pro Gly Phe Gly Val Asp Gln Leu Arg Asp Asp Asn Leu Glu Thr Tyr 
    50                  55                  60                  


Trp Gln Ser Asp Gly Ser Gln Pro His Leu Val Asn Ile Gln Phe Arg 
65                  70                  75                  80  


Arg Lys Thr Thr Val Lys Thr Leu Cys Ile Tyr Ala Asp Tyr Lys Ser 
                85                  90                  95      


Asp Glu Ser Tyr Thr Pro Ser Lys Ile Ser Val Arg Val Gly Asn Asn 
            100                 105                 110         


Phe His Asn Leu Gln Glu Ile Arg Gln Leu Glu Leu Val Glu Pro Ser 
        115                 120                 125             


Gly Trp Ile His Val Pro Leu Thr Asp Asn His Lys Lys Pro Thr Arg 
    130                 135                 140                 


Thr Phe Met Ile Gln Ile Ala Val Leu Ala Asn His Gln Asn Gly Arg 
145                 150                 155                 160 


Asp Thr His Met Arg Gln Ile Lys Ile Tyr Thr Pro Val Glu Glu Ser 
                165                 170                 175     


Ser Ile Gly Lys Phe Pro Arg Cys Thr Thr Ile Asp Phe Met Met Tyr 
            180                 185                 190         


Arg Ser Ile Arg 
        195     


<210>  508
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC11__Homo_sapiens__NP_001002244

<400>  508

Met Lys Val Lys Ile Lys Cys Trp Asn Gly Val Ala Thr Trp Leu Trp 
1               5                   10                  15      


Val Ala Asn Asp Glu Asn Cys Gly Ile Cys Arg Met Ala Phe Asn Gly 
            20                  25                  30          


Cys Cys Pro Asp Cys Pro Leu His Gly Glu Ser Ile Ser Arg Cys Leu 
        35                  40                  45              


Gly Trp Cys Pro Gln Pro Val Pro Val Leu Gly Gly Arg Ala His Pro 
    50                  55                  60                  


Gln Val Pro Ile Asn Thr Ala Ser Pro Thr Pro Gly Gln His Thr Gly 
65                  70                  75                  80  


Ser Leu Met Ser Arg Glu Glu Ser Ser Arg Ser Pro Asp Pro Thr Pro 
                85                  90                  95      


Pro Ala Leu Asp Gln Glu Thr Ser Ser Leu Leu Arg Cys Thr Ser Pro 
            100                 105                 110         


Trp Cys Leu Asp His Ser Cys Asp Leu Phe Gly Ile Thr Asp Gln Val 
        115                 120                 125             


Ser Ala Asp Gly Pro Arg Ala Cys Arg Gln Gly Ala Arg Arg Arg Leu 
    130                 135                 140                 


Pro Ala Gly Val Gly Pro Val Leu Pro Leu Leu Pro His Ala Leu His 
145                 150                 155                 160 


Pro Gln Val Ala Ala Arg Thr Ala Gly Ala Ala Ala Leu Pro His Val 
                165                 170                 175     


Pro Pro Gly Met Glu Val Gln Gly Val Arg Pro Asp Leu Ala Leu Ala 
            180                 185                 190         


Gly Gly Ala Ser 
        195     


<210>  509
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC13__Homo_sapiens__NP_001229304

<400>  509

Met Asp Ser Glu Val Gln Arg Asp Gly Arg Ile Leu Asp Leu Ile Asp 
1               5                   10                  15      


Asp Ala Trp Arg Glu Asp Lys Leu Pro Tyr Glu Asp Val Ala Ile Pro 
            20                  25                  30          


Leu Asn Glu Leu Pro Glu Pro Glu Gln Asp Asn Gly Gly Thr Thr Glu 
        35                  40                  45              


Ser Val Lys Glu Gln Glu Met Lys Trp Thr Asp Leu Ala Leu Gln Tyr 
    50                  55                  60                  


Leu His Glu Asn Val Pro Pro Ile Gly Asn 
65                  70                  


<210>  510
<211>  1944
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC1__Homo_sapiens__NP_073153

<400>  510

Met Ser Asn Phe Tyr Glu Glu Arg Thr Thr Met Ile Ala Ala Arg Asp 
1               5                   10                  15      


Leu Gln Glu Phe Val Pro Phe Gly Arg Asp His Cys Lys His His Pro 
            20                  25                  30          


Asn Ala Leu Asn Leu Gln Leu Arg Gln Leu Gln Pro Ala Ser Glu Leu 
        35                  40                  45              


Trp Ser Ser Asp Gly Ala Ala Gly Leu Val Gly Ser Leu Gln Glu Val 
    50                  55                  60                  


Thr Ile His Glu Lys Gln Lys Glu Ser Trp Gln Leu Arg Lys Gly Val 
65                  70                  75                  80  


Ser Glu Ile Gly Glu Asp Val Asp Tyr Asp Glu Glu Leu Tyr Val Ala 
                85                  90                  95      


Gly Asn Met Val Ile Trp Ser Lys Gly Ser Lys Ser Gln Ala Leu Ala 
            100                 105                 110         


Val Tyr Lys Ala Phe Thr Val Asp Ser Pro Val Gln Gln Ala Leu Trp 
        115                 120                 125             


Cys Asp Phe Ile Ile Ser Gln Asp Lys Ser Glu Lys Ala Tyr Ser Ser 
    130                 135                 140                 


Asn Glu Val Glu Lys Cys Ile Cys Ile Leu Gln Ser Ser Cys Ile Asn 
145                 150                 155                 160 


Met His Ser Ile Glu Gly Lys Asp Tyr Ile Ala Ser Leu Pro Phe Gln 
                165                 170                 175     


Val Ala Asn Val Trp Pro Thr Lys Tyr Gly Leu Leu Phe Glu Arg Ser 
            180                 185                 190         


Ala Ser Ser His Glu Val Pro Pro Gly Ser Pro Arg Glu Pro Leu Pro 
        195                 200                 205             


Thr Met Phe Ser Met Leu His Pro Leu Asp Glu Ile Thr Pro Leu Val 
    210                 215                 220                 


Cys Lys Ser Gly Ser Leu Phe Gly Ser Ser Arg Val Gln Tyr Val Val 
225                 230                 235                 240 


Asp His Ala Met Lys Ile Val Phe Leu Asn Thr Asp Pro Ser Ile Val 
                245                 250                 255     


Met Thr Tyr Asp Ala Val Gln Asn Val His Ser Val Trp Thr Leu Arg 
            260                 265                 270         


Arg Val Lys Ser Glu Glu Glu Asn Val Val Leu Lys Phe Ser Glu Gln 
        275                 280                 285             


Gly Gly Thr Pro Gln Asn Val Ala Thr Ser Ser Ser Leu Thr Ala His 
    290                 295                 300                 


Leu Arg Ser Leu Ser Lys Gly Asp Ser Pro Val Thr Ser Pro Phe Gln 
305                 310                 315                 320 


Asn Tyr Ser Ser Ile His Ser Gln Ser Arg Ser Thr Ser Ser Pro Ser 
                325                 330                 335     


Leu His Ser Arg Ser Pro Ser Ile Ser Asn Met Ala Ala Leu Ser Arg 
            340                 345                 350         


Ala His Ser Pro Ala Leu Gly Val His Ser Phe Ser Gly Val Gln Arg 
        355                 360                 365             


Phe Asn Ile Ser Ser His Asn Gln Ser Pro Lys Arg His Ser Ile Ser 
    370                 375                 380                 


His Ser Pro Asn Ser Asn Ser Asn Gly Ser Phe Leu Ala Pro Glu Thr 
385                 390                 395                 400 


Glu Pro Ile Val Pro Glu Leu Cys Ile Asp His Leu Trp Thr Glu Thr 
                405                 410                 415     


Ile Thr Asn Ile Arg Glu Lys Asn Ser Gln Ala Ser Lys Val Phe Ile 
            420                 425                 430         


Thr Ser Asp Leu Cys Gly Gln Lys Phe Leu Cys Phe Leu Val Glu Ser 
        435                 440                 445             


Gln Leu Gln Leu Arg Cys Val Lys Phe Gln Glu Ser Asn Asp Lys Thr 
    450                 455                 460                 


Gln Leu Ile Phe Gly Ser Val Thr Asn Ile Pro Ala Lys Asp Ala Ala 
465                 470                 475                 480 


Pro Val Glu Lys Ile Asp Thr Met Leu Val Leu Glu Gly Ser Gly Asn 
                485                 490                 495     


Leu Val Leu Tyr Thr Gly Val Val Arg Val Gly Lys Val Phe Ile Pro 
            500                 505                 510         


Gly Leu Pro Ala Pro Ser Leu Thr Met Ser Asn Thr Met Pro Arg Pro 
        515                 520                 525             


Ser Thr Pro Leu Asp Gly Val Ser Thr Pro Lys Pro Leu Ser Lys Leu 
    530                 535                 540                 


Leu Gly Ser Leu Asp Glu Val Val Leu Leu Ser Pro Val Pro Glu Leu 
545                 550                 555                 560 


Arg Asp Ser Ser Lys Leu His Asp Ser Leu Tyr Asn Glu Asp Cys Thr 
                565                 570                 575     


Phe Gln Gln Leu Gly Thr Tyr Ile His Ser Ile Arg Asp Pro Val His 
            580                 585                 590         


Asn Arg Val Thr Leu Glu Leu Ser Asn Gly Ser Met Val Arg Ile Thr 
        595                 600                 605             


Ile Pro Glu Ile Ala Thr Ser Glu Leu Val Gln Thr Cys Leu Gln Ala 
    610                 615                 620                 


Ile Lys Phe Ile Leu Pro Lys Glu Ile Ala Val Gln Met Leu Val Lys 
625                 630                 635                 640 


Trp Tyr Asn Val His Ser Ala Pro Gly Gly Pro Ser Tyr His Ser Glu 
                645                 650                 655     


Trp Asn Leu Phe Val Thr Cys Leu Met Asn Met Met Gly Tyr Asn Thr 
            660                 665                 670         


Asp Arg Leu Ala Trp Thr Arg Asn Phe Asp Phe Glu Gly Ser Leu Ser 
        675                 680                 685             


Pro Val Ile Ala Pro Lys Lys Ala Arg Pro Ser Glu Thr Gly Ser Asp 
    690                 695                 700                 


Asp Asp Trp Glu Tyr Leu Leu Asn Ser Asp Tyr His Gln Asn Val Glu 
705                 710                 715                 720 


Ser His Leu Leu Asn Arg Ser Leu Cys Leu Ser Pro Ser Glu Ala Ser 
                725                 730                 735     


Gln Met Lys Asp Glu Asp Phe Ser Gln Asn Leu Ser Leu Asp Ser Ser 
            740                 745                 750         


Thr Leu Leu Phe Thr His Ile Pro Ala Ile Phe Phe Val Leu His Leu 
        755                 760                 765             


Val Tyr Glu Glu Leu Lys Leu Asn Thr Leu Met Gly Glu Gly Ile Cys 
    770                 775                 780                 


Ser Leu Val Glu Leu Leu Val Gln Leu Ala Arg Asp Leu Lys Leu Gly 
785                 790                 795                 800 


Pro Tyr Val Asp His Tyr Tyr Arg Asp Tyr Pro Thr Leu Val Arg Thr 
                805                 810                 815     


Thr Gly Gln Val Cys Thr Ile Asp Pro Gly Gln Thr Gly Phe Met His 
            820                 825                 830         


His Pro Ser Phe Phe Thr Ser Glu Pro Pro Ser Ile Tyr Gln Trp Val 
        835                 840                 845             


Ser Ser Cys Leu Lys Gly Glu Gly Met Pro Pro Tyr Pro Tyr Leu Pro 
    850                 855                 860                 


Gly Ile Cys Glu Arg Ser Arg Leu Val Val Leu Ser Ile Ala Leu Tyr 
865                 870                 875                 880 


Ile Leu Gly Asp Glu Ser Leu Val Ser Asp Glu Ser Ser Gln Tyr Leu 
                885                 890                 895     


Thr Arg Ile Thr Ile Ala Pro Gln Lys Leu Gln Val Glu Gln Glu Glu 
            900                 905                 910         


Asn Arg Phe Ser Phe Arg His Ser Thr Ser Val Ser Ser Leu Ala Glu 
        915                 920                 925             


Arg Leu Val Val Trp Met Thr Asn Val Gly Phe Thr Leu Arg Asp Leu 
    930                 935                 940                 


Glu Thr Leu Pro Phe Gly Ile Ala Leu Pro Ile Arg Asp Ala Ile Tyr 
945                 950                 955                 960 


His Cys Arg Glu Gln Pro Ala Ser Asp Trp Pro Glu Ala Val Cys Leu 
                965                 970                 975     


Leu Ile Gly Arg Gln Asp Leu Ser Lys Gln Ala Cys Glu Gly Asn Leu 
            980                 985                 990         


Pro Lys Gly Lys Ser Val Leu Ser  Ser Asp Val Pro Ser  Gly Thr Glu 
        995                 1000                 1005             


Thr Glu  Glu Glu Asp Asp Gly  Met Asn Asp Met Asn  His Glu Val 
    1010                 1015                 1020             


Met Ser  Leu Ile Trp Ser Glu  Asp Leu Arg Val Gln  Asp Val Arg 
    1025                 1030                 1035             


Arg Leu  Leu Gln Ser Ala His  Pro Val Arg Val Asn  Val Val Gln 
    1040                 1045                 1050             


Tyr Pro  Glu Leu Ser Asp His  Glu Phe Ile Glu Glu  Lys Glu Asn 
    1055                 1060                 1065             


Arg Leu  Leu Gln Leu Cys Gln  Arg Thr Met Ala Leu  Pro Val Gly 
    1070                 1075                 1080             


Arg Gly  Met Phe Thr Leu Phe  Ser Tyr His Pro Val  Pro Thr Glu 
    1085                 1090                 1095             


Pro Leu  Pro Ile Pro Lys Leu  Asn Leu Thr Gly Arg  Ala Pro Pro 
    1100                 1105                 1110             


Arg Asn  Thr Thr Val Asp Leu  Asn Ser Gly Asn Ile  Asp Val Pro 
    1115                 1120                 1125             


Pro Asn  Met Thr Ser Trp Ala  Ser Phe His Asn Gly  Val Ala Ala 
    1130                 1135                 1140             


Gly Leu  Lys Ile Ala Pro Ala  Ser Gln Ile Asp Ser  Ala Trp Ile 
    1145                 1150                 1155             


Val Tyr  Asn Lys Pro Lys His  Ala Glu Leu Ala Asn  Glu Tyr Ala 
    1160                 1165                 1170             


Gly Phe  Leu Met Ala Leu Gly  Leu Asn Gly His Leu  Thr Lys Leu 
    1175                 1180                 1185             


Ala Thr  Leu Asn Ile His Asp  Tyr Leu Thr Lys Gly  His Glu Met 
    1190                 1195                 1200             


Thr Ser  Ile Gly Leu Leu Leu  Gly Val Ser Ala Ala  Lys Leu Gly 
    1205                 1210                 1215             


Thr Met  Asp Met Ser Ile Thr  Arg Leu Leu Ser Ile  His Ile Pro 
    1220                 1225                 1230             


Ala Leu  Leu Pro Pro Thr Ser  Thr Glu Leu Asp Val  Pro His Asn 
    1235                 1240                 1245             


Val Gln  Val Ala Ala Val Val  Gly Ile Gly Leu Val  Tyr Gln Gly 
    1250                 1255                 1260             


Thr Ala  His Arg His Thr Ala  Glu Val Leu Leu Ala  Glu Ile Gly 
    1265                 1270                 1275             


Arg Pro  Pro Gly Pro Glu Met  Glu Tyr Cys Thr Asp  Arg Glu Ser 
    1280                 1285                 1290             


Tyr Ser  Leu Ala Ala Gly Leu  Ala Leu Gly Met Val  Cys Leu Gly 
    1295                 1300                 1305             


His Gly  Ser Asn Leu Ile Gly  Met Ser Asp Leu Asn  Val Pro Glu 
    1310                 1315                 1320             


Gln Leu  Tyr Gln Tyr Met Val  Gly Gly His Arg Arg  Phe Gln Thr 
    1325                 1330                 1335             


Gly Met  His Arg Glu Lys His  Lys Ser Pro Ser Tyr  Gln Ile Lys 
    1340                 1345                 1350             


Glu Gly  Asp Thr Ile Asn Val  Asp Val Thr Cys Pro  Gly Ala Thr 
    1355                 1360                 1365             


Leu Ala  Leu Ala Met Ile Tyr  Leu Lys Thr Asn Asn  Arg Ser Ile 
    1370                 1375                 1380             


Ala Asp  Trp Leu Arg Ala Pro  Asp Thr Met Tyr Leu  Leu Asp Phe 
    1385                 1390                 1395             


Val Lys  Pro Glu Phe Leu Leu  Leu Arg Thr Leu Ala  Arg Cys Leu 
    1400                 1405                 1410             


Ile Leu  Trp Asp Asp Ile Leu  Pro Asn Ser Lys Trp  Val Asp Ser 
    1415                 1420                 1425             


Asn Val  Pro Gln Ile Ile Arg  Glu Asn Ser Ile Ser  Leu Ser Glu 
    1430                 1435                 1440             


Ile Glu  Leu Pro Cys Ser Glu  Asp Leu Asn Leu Glu  Thr Leu Ser 
    1445                 1450                 1455             


Gln Ala  His Val Tyr Ile Ile  Ala Gly Ala Cys Leu  Ser Leu Gly 
    1460                 1465                 1470             


Phe Arg  Phe Ala Gly Ser Glu  Asn Leu Ser Ala Phe  Asn Cys Leu 
    1475                 1480                 1485             


His Lys  Phe Ala Lys Asp Phe  Met Thr Tyr Leu Ser  Ala Pro Asn 
    1490                 1495                 1500             


Ala Ser  Val Thr Gly Pro His  Asn Leu Glu Thr Cys  Leu Ser Val 
    1505                 1510                 1515             


Val Leu  Leu Ser Leu Ala Met  Val Met Ala Gly Ser  Gly Asn Leu 
    1520                 1525                 1530             


Lys Val  Leu Gln Leu Cys Arg  Phe Leu His Met Lys  Thr Gly Gly 
    1535                 1540                 1545             


Glu Met  Asn Tyr Gly Phe His  Leu Ala His His Met  Ala Leu Gly 
    1550                 1555                 1560             


Leu Leu  Phe Leu Gly Gly Gly  Arg Tyr Ser Leu Ser  Thr Ser Asn 
    1565                 1570                 1575             


Ser Ser  Ile Ala Ala Leu Leu  Cys Ala Leu Tyr Pro  His Phe Pro 
    1580                 1585                 1590             


Ala His  Ser Thr Asp Asn Arg  Tyr His Leu Gln Ala  Leu Arg His 
    1595                 1600                 1605             


Leu Tyr  Val Leu Ala Ala Glu  Pro Arg Leu Leu Val  Pro Val Asp 
    1610                 1615                 1620             


Val Asp  Thr Asn Thr Pro Cys  Tyr Ala Leu Leu Glu  Val Thr Tyr 
    1625                 1630                 1635             


Lys Gly  Thr Gln Trp Tyr Glu  Gln Thr Lys Glu Glu  Leu Met Ala 
    1640                 1645                 1650             


Pro Thr  Leu Leu Pro Glu Leu  His Leu Leu Lys Gln  Ile Lys Val 
    1655                 1660                 1665             


Lys Gly  Pro Arg Tyr Trp Glu  Leu Leu Ile Asp Leu  Ser Lys Gly 
    1670                 1675                 1680             


Thr Gln  His Leu Lys Ser Ile  Leu Ser Lys Asp Gly  Val Leu Tyr 
    1685                 1690                 1695             


Val Lys  Leu Arg Ala Gly Gln  Leu Ser Tyr Lys Glu  Asp Pro Met 
    1700                 1705                 1710             


Gly Trp  Gln Ser Leu Leu Ala  Gln Thr Val Ala Asn  Arg Asn Ser 
    1715                 1720                 1725             


Glu Ala  Arg Ala Phe Lys Pro  Glu Thr Ile Ser Ala  Phe Thr Ser 
    1730                 1735                 1740             


Asp Pro  Ala Leu Leu Ser Phe  Ala Glu Tyr Phe Cys  Lys Pro Thr 
    1745                 1750                 1755             


Val Asn  Met Gly Gln Lys Gln  Glu Ile Leu Asp Leu  Phe Ser Ser 
    1760                 1765                 1770             


Val Leu  Tyr Glu Cys Val Thr  Gln Glu Thr Pro Glu  Met Leu Pro 
    1775                 1780                 1785             


Ala Tyr  Ile Ala Met Asp Gln  Ala Ile Arg Arg Leu  Gly Arg Arg 
    1790                 1795                 1800             


Glu Met  Ser Glu Thr Ser Glu  Leu Trp Gln Ile Lys  Leu Val Leu 
    1805                 1810                 1815             


Glu Phe  Phe Ser Ser Arg Ser  His Gln Glu Arg Leu  Gln Asn His 
    1820                 1825                 1830             


Pro Lys  Arg Gly Leu Phe Met  Asn Ser Glu Phe Leu  Pro Val Val 
    1835                 1840                 1845             


Lys Cys  Thr Ile Asp Asn Thr  Leu Asp Gln Trp Leu  Gln Val Gly 
    1850                 1855                 1860             


Gly Asp  Met Cys Val His Ala  Tyr Leu Ser Gly Gln  Pro Leu Glu 
    1865                 1870                 1875             


Glu Ser  Gln Leu Ser Met Leu  Ala Cys Phe Leu Val  Tyr His Ser 
    1880                 1885                 1890             


Val Pro  Ala Pro Gln His Leu  Pro Pro Ile Gly Leu  Glu Gly Ser 
    1895                 1900                 1905             


Thr Ser  Phe Ala Glu Leu Leu  Phe Lys Phe Lys Gln  Leu Lys Met 
    1910                 1915                 1920             


Pro Val  Arg Ala Leu Leu Arg  Leu Ala Pro Leu Leu  Leu Gly Asn 
    1925                 1930                 1935             


Pro Gln  Pro Met Val Met 
    1940                 


<210>  511
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC2__Homo_sapiens__NP_037498

<400>  511

Met Ala Ala Ala Val Val Val Ala Glu Gly Asp Ser Asp Ser Arg Pro 
1               5                   10                  15      


Gly Gln Glu Leu Leu Val Ala Trp Asn Thr Val Ser Thr Gly Leu Val 
            20                  25                  30          


Pro Pro Ala Ala Leu Gly Leu Val Ser Ser Arg Thr Ser Gly Ala Val 
        35                  40                  45              


Pro Pro Lys Glu Glu Glu Leu Arg Ala Ala Val Glu Val Leu Arg Gly 
    50                  55                  60                  


His Gly Leu His Ser Val Leu Glu Glu Trp Phe Val Glu Val Leu Gln 
65                  70                  75                  80  


Asn Asp Leu Gln Ala Asn Ile Ser Pro Glu Phe Trp Asn Ala Ile Ser 
                85                  90                  95      


Gln Cys Glu Asn Ser Ala Asp Glu Pro Gln Cys Leu Leu Leu Leu Leu 
            100                 105                 110         


Asp Ala Phe Gly Leu Leu Glu Ser Arg Leu Asp Pro Tyr Leu Arg Ser 
        115                 120                 125             


Leu Glu Leu Leu Glu Lys Trp Thr Arg Leu Gly Leu Leu Met Gly Thr 
    130                 135                 140                 


Gly Ala Gln Gly Leu Arg Glu Glu Val His Thr Met Leu Arg Gly Val 
145                 150                 155                 160 


Leu Phe Phe Ser Thr Pro Arg Thr Phe Gln Glu Met Ile Gln Arg Leu 
                165                 170                 175     


Tyr Gly Cys Phe Leu Arg Val Tyr Met Gln Ser Lys Arg Lys Gly Glu 
            180                 185                 190         


Gly Gly Thr Asp Pro Glu Leu Glu Gly Glu Leu Asp Ser Arg Tyr Ala 
        195                 200                 205             


Arg Arg Arg Tyr Tyr Arg Leu Leu Gln Ser Pro Leu Cys Ala Gly Cys 
    210                 215                 220                 


Ser Ser Asp Lys Gln Gln Cys Trp Cys Arg Gln Ala Leu Glu Gln Phe 
225                 230                 235                 240 


His Gln Leu Ser Gln Val Leu His Arg Leu Ser Leu Leu Glu Arg Val 
                245                 250                 255     


Ser Ala Glu Ala Val Thr Thr Thr Leu His Gln Val Thr Arg Glu Arg 
            260                 265                 270         


Met Glu Asp Arg Cys Arg Gly Glu Tyr Glu Arg Ser Phe Leu Arg Glu 
        275                 280                 285             


Phe His Lys Trp Ile Glu Arg Val Val Gly Trp Leu Gly Lys Val Phe 
    290                 295                 300                 


Leu Gln Asp Gly Pro Ala Arg Pro Ala Ser Pro Glu Ala Gly Asn Thr 
305                 310                 315                 320 


Leu Arg Arg Trp Arg Cys His Val Gln Arg Phe Phe Tyr Arg Ile Tyr 
                325                 330                 335     


Ala Ser Leu Arg Ile Glu Glu Leu Phe Ser Ile Val Arg Asp Phe Pro 
            340                 345                 350         


Asp Ser Arg Pro Ala Ile Glu Asp Leu Lys Tyr Cys Leu Glu Arg Thr 
        355                 360                 365             


Asp Gln Arg Gln Gln Leu Leu Val Ser Leu Lys Ala Ala Leu Glu Thr 
    370                 375                 380                 


Arg Leu Leu His Pro Gly Val Asn Thr Cys Asp Ile Ile Thr Leu Tyr 
385                 390                 395                 400 


Ile Ser Ala Ile Lys Ala Leu Arg Val Leu Asp Pro Ser Met Val Ile 
                405                 410                 415     


Leu Glu Val Ala Cys Glu Pro Ile Arg Arg Tyr Leu Arg Thr Arg Glu 
            420                 425                 430         


Asp Thr Val Arg Gln Ile Val Ala Gly Leu Thr Gly Asp Ser Asp Gly 
        435                 440                 445             


Thr Gly Asp Leu Ala Val Glu Leu Ser Lys Thr Asp Pro Ala Ser Leu 
    450                 455                 460                 


Glu Thr Gly Gln Asp Ser Glu Asp Asp Ser Gly Glu Pro Glu Asp Trp 
465                 470                 475                 480 


Val Pro Asp Pro Val Asp Ala Asp Pro Gly Lys Ser Ser Ser Lys Arg 
                485                 490                 495     


Arg Ser Ser Asp Ile Ile Ser Leu Leu Val Ser Ile Tyr Gly Ser Lys 
            500                 505                 510         


Asp Leu Phe Ile Asn Glu Tyr Arg Ser Leu Leu Ala Asp Arg Leu Leu 
        515                 520                 525             


His Gln Phe Ser Phe Ser Pro Glu Arg Glu Ile Arg Asn Val Glu Leu 
    530                 535                 540                 


Leu Lys Leu Arg Phe Gly Glu Ala Pro Met His Phe Cys Glu Val Met 
545                 550                 555                 560 


Leu Lys Asp Met Ala Asp Ser Arg Arg Ile Asn Ala Asn Ile Arg Glu 
                565                 570                 575     


Glu Asp Glu Lys Arg Pro Ala Glu Glu Gln Pro Pro Phe Gly Val Tyr 
            580                 585                 590         


Ala Val Ile Leu Ser Ser Glu Phe Trp Pro Pro Phe Lys Asp Glu Lys 
        595                 600                 605             


Leu Glu Val Pro Glu Asp Ile Arg Ala Ala Leu Glu Ala Tyr Cys Lys 
    610                 615                 620                 


Lys Tyr Glu Gln Leu Lys Ala Met Arg Thr Leu Ser Trp Lys His Thr 
625                 630                 635                 640 


Leu Gly Leu Val Thr Met Asp Val Glu Leu Ala Asp Arg Thr Leu Ser 
                645                 650                 655     


Val Ala Val Thr Pro Val Gln Ala Val Ile Leu Leu Tyr Phe Gln Asp 
            660                 665                 670         


Gln Ala Ser Trp Thr Leu Glu Glu Leu Ser Lys Ala Val Lys Met Pro 
        675                 680                 685             


Val Ala Leu Leu Arg Arg Arg Met Ser Val Trp Leu Gln Gln Gly Val 
    690                 695                 700                 


Leu Arg Glu Glu Pro Pro Gly Thr Phe Ser Val Ile Glu Glu Glu Arg 
705                 710                 715                 720 


Pro Gln Asp Arg Asp Asn Met Val Leu Ile Asp Ser Asp Asp Glu Ser 
                725                 730                 735     


Asp Ser Gly Met Ala Ser Gln Ala Asp Gln Lys Glu Glu Glu Leu Leu 
            740                 745                 750         


Leu Phe Trp Thr Tyr Ile Gln Ala Met Leu Thr Asn Leu Glu Ser Leu 
        755                 760                 765             


Ser Leu Asp Arg Ile Tyr Asn Met Leu Arg Met Phe Val Val Thr Gly 
    770                 775                 780                 


Pro Ala Leu Ala Glu Ile Asp Leu Gln Glu Leu Gln Gly Tyr Leu Gln 
785                 790                 795                 800 


Lys Lys Val Arg Asp Gln Gln Leu Val Tyr Ser Ala Gly Val Tyr Arg 
                805                 810                 815     


Leu Pro Lys Asn Cys Ser 
            820         


<210>  512
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC4__Homo_sapiens__NP_001273685

<400>  512

Met Leu Arg Phe Pro Thr Cys Phe Pro Ser Phe Arg Val Val Gly Glu 
1               5                   10                  15      


Lys Gln Leu Pro Gln Glu Ile Ile Phe Leu Val Trp Ser Pro Lys Arg 
            20                  25                  30          


Asp Leu Ile Ala Leu Ala Asn Thr Ala Gly Glu Val Leu Leu His Arg 
        35                  40                  45              


Leu Ala Ser Phe His Arg Val Trp Ser Phe Pro Pro Asn Glu Asn Thr 
    50                  55                  60                  


Gly Lys Glu Val Thr Cys Leu Ala Trp Arg Pro Asp Gly Lys Leu Leu 
65                  70                  75                  80  


Ala Phe Ala Leu Ala Asp Thr Lys Lys Ile Val Leu Cys Asp Val Glu 
                85                  90                  95      


Lys Pro Glu Ser Leu His Ser Phe Ser Val Glu Ala Pro Val Ser Cys 
            100                 105                 110         


Met His Trp Met Glu Val Thr Val Glu Ser Ser Val Leu Thr Ser Phe 
        115                 120                 125             


Tyr Asn Ala Glu Asp Glu Ser Asn Leu Leu Leu Pro Lys Leu Pro Thr 
    130                 135                 140                 


Leu Pro Lys Asn Tyr Ser Asn Thr Ser Lys Ile Phe Ser Glu Glu Asn 
145                 150                 155                 160 


Ser Asp Glu Ile Ile Lys Leu Leu Gly Asp Val Arg Leu Asn Ile Leu 
                165                 170                 175     


Val Leu Gly Gly Ser Ser Gly Phe Ile Glu Leu Tyr Ala Tyr Gly Met 
            180                 185                 190         


Phe Lys Ile Ala Arg Val Thr Gly Ile Ala Gly Thr Cys Leu Ala Leu 
        195                 200                 205             


Cys Leu Ser Ser Asp Leu Lys Ser Leu Ser Val Val Thr Glu Val Ser 
    210                 215                 220                 


Thr Asn Gly Ala Ser Glu Val Ser Tyr Phe Gln Leu Glu Thr Asn Leu 
225                 230                 235                 240 


Leu Tyr Ser Phe Leu Pro Glu Val Thr Arg Met Ala Arg Lys Phe Thr 
                245                 250                 255     


His Ile Ser Ala Leu Leu Gln Tyr Ile Asn Leu Ser Leu Thr Cys Met 
            260                 265                 270         


Cys Glu Ala Trp Glu Glu Ile Leu Met Gln Met Asp Ser Arg Leu Thr 
        275                 280                 285             


Lys Phe Val Gln Glu Lys Asn Thr Thr Thr Ser Val Gln Asp Glu Phe 
    290                 295                 300                 


Met His Leu Leu Leu Trp Gly Lys Ala Ser Ala Glu Leu Gln Thr Leu 
305                 310                 315                 320 


Leu Met Asn Gln Leu Thr Val Lys Gly Leu Lys Lys Leu Gly Gln Ser 
                325                 330                 335     


Ile Glu Ser Ser Tyr Ser Ser Ile Gln Lys Leu Val Ile Ser His Leu 
            340                 345                 350         


Gln Ser Gly Ser Glu Ser Leu Leu Tyr His Leu Ser Glu Leu Lys Gly 
        355                 360                 365             


Met Ala Ser Trp Lys Gln Lys Tyr Glu Pro Leu Gly Leu Asp Ala Ala 
    370                 375                 380                 


Gly Ile Glu Glu Ala Ile Thr Ala Val Gly Ser Phe Ile Leu Lys Ala 
385                 390                 395                 400 


Asn Glu Leu Leu Gln Val Ile Asp Ser Ser Met Lys Asn Phe Lys Ala 
                405                 410                 415     


Phe Phe Arg Trp Leu Tyr Val Ala Met Leu Arg Met Thr Glu Asp His 
            420                 425                 430         


Val Leu Pro Glu Leu Asn Lys Val Met Thr Gln Lys Asp Ile Thr Phe 
        435                 440                 445             


Val Ala Glu Phe Leu Thr Glu His Phe Asn Glu Ala Pro Asp Leu Tyr 
    450                 455                 460                 


Asn Arg Lys Gly Lys Tyr Phe Asn Val Glu Arg Val Gly Gln Tyr Leu 
465                 470                 475                 480 


Lys Asp Glu Asp Asp Asp Leu Val Ser Pro Pro Asn Thr Glu Gly Asn 
                485                 490                 495     


Gln Trp Tyr Asp Phe Leu Gln Asn Ser Ser His Leu Lys Glu Ser Pro 
            500                 505                 510         


Leu Leu Phe Pro Tyr Tyr Pro Arg Lys Ser Leu His Phe Val Lys Arg 
        515                 520                 525             


Arg Met Glu Asn Ile Ile Asp Gln Cys Leu Gln Lys Pro Ala Asp Val 
    530                 535                 540                 


Ile Gly Lys Ser Met Asn Gln Ala Ile Cys Ile Pro Leu Tyr Arg Asp 
545                 550                 555                 560 


Thr Arg Ser Glu Asp Ser Thr Arg Arg Leu Phe Lys Phe Pro Phe Leu 
                565                 570                 575     


Trp Asn Asn Lys Thr Ser Asn Leu His Tyr Leu Leu Phe Thr Ile Leu 
            580                 585                 590         


Glu Asp Ser Leu Tyr Lys Met Cys Ile Leu Arg Arg His Thr Asp Ile 
        595                 600                 605             


Ser Gln Ser Val Ser Asn Gly Leu Ile Ala Ile Lys Phe Gly Ser Phe 
    610                 615                 620                 


Thr Tyr Ala Thr Thr Glu Lys Val Arg Arg Ser Ile Tyr Ser Cys Leu 
625                 630                 635                 640 


Asp Ala Gln Phe Tyr Asp Asp Glu Thr Val Thr Val Val Leu Lys Asp 
                645                 650                 655     


Thr Val Gly Arg Glu Gly Arg Asp Arg Leu Leu Val Gln Leu Pro Leu 
            660                 665                 670         


Ser Leu Val Tyr Asn Ser Glu Asp Ser Ala Glu Tyr Gln Phe Thr Gly 
        675                 680                 685             


Thr Tyr Ser Thr Arg Leu Asp Glu Gln Cys Ser Ala Ile Pro Thr Arg 
    690                 695                 700                 


Thr Met His Phe Glu Lys His Trp Arg Leu Leu Glu Ser Met Lys Ala 
705                 710                 715                 720 


Gln Tyr Val Ala Gly Asn Gly Phe Arg Lys Val Ser Cys Val Leu Ser 
                725                 730                 735     


Ser Asn Leu Arg His Val Arg Val Phe Glu Met Asp Ile Asp Asp Glu 
            740                 745                 750         


Trp Glu Leu Asp Glu Ser Ser Asp Glu Glu Glu Glu Ala Ser Asn Lys 
        755                 760                 765             


Pro Val Lys Ile Lys Glu Glu Val Leu Ser Glu Ser Glu Ala Glu Asn 
    770                 775                 780                 


Gln Gln Ala Gly Ala Ala Ala Leu Ala Pro Glu Ile Val Ile Lys Val 
785                 790                 795                 800 


Glu Lys Leu Asp Pro Glu Leu Asp Ser 
                805                 


<210>  513
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC5__Homo_sapiens__NP_001131031

<400>  513

Met Ala Glu Gly Glu Leu Lys Asp Met Glu Gln Phe Phe Asp Asp Leu 
1               5                   10                  15      


Ser Asp Ser Phe Ser Gly Thr Glu Pro Glu Val His Lys Thr Ser Val 
            20                  25                  30          


Val Gly Leu Phe Leu Arg His Met Ile Leu Ala Tyr Ser Lys Leu Ser 
        35                  40                  45              


Phe Ser Gln Val Phe Lys Leu Tyr Thr Ala Leu Gln Gln Tyr Phe Gln 
    50                  55                  60                  


Asn Gly Glu Lys Lys Thr Val Glu Asp Ala Asp Met Glu Leu Thr Ser 
65                  70                  75                  80  


Arg Asp Glu Gly Glu Arg Lys Met Glu Lys Glu Glu Leu Asp Val Ser 
                85                  90                  95      


Val Arg Glu Glu Glu Val Ser Cys Ser Gly Pro Leu Ser Gln Lys Gln 
            100                 105                 110         


Ala Glu Phe Phe Leu Ser Gln Gln Ala Ser Leu Leu Lys Asn Asp Glu 
        115                 120                 125             


Thr Lys Ala Leu Thr Pro Ala Ser Leu Gln Lys Glu Leu Asn Asn Leu 
    130                 135                 140                 


Leu Lys Phe Asn Pro Asp Phe Ala Glu Ala His Tyr Leu Ser Tyr Leu 
145                 150                 155                 160 


Asn Asn Leu Arg Val Gln Asp Val Phe Ser Ser Thr His Ser Leu Leu 
                165                 170                 175     


His Tyr Phe Asp Arg Leu Ile Leu Thr Gly Ala Glu Ser Lys Ser Asn 
            180                 185                 190         


Gly Glu Glu Gly Tyr Gly Arg Ser Leu Arg Tyr Ala Ala Leu Asn Leu 
        195                 200                 205             


Ala Ala Leu His Cys Arg Phe Gly His Tyr Gln Gln Ala Glu Leu Ala 
    210                 215                 220                 


Leu Gln Glu Ala Ile Arg Ile Ala Gln Glu Ser Asn Asp His Val Cys 
225                 230                 235                 240 


Leu Gln His Cys Leu Ser Trp Leu Tyr Val Leu Gly Gln Lys Arg Ser 
                245                 250                 255     


Asp Ser Tyr Val Leu Leu Glu His Ser Val Lys Lys Ala Val His Phe 
            260                 265                 270         


Gly Leu Pro Arg Ala Phe Ala Gly Lys Thr Ala Asn Lys Leu Met Asp 
        275                 280                 285             


Ala Leu Lys Asp Ser Asp Leu Leu His Trp Lys His Ser Leu Ser Glu 
    290                 295                 300                 


Leu Ile Asp Ile Ser Ile Ala Gln Lys Thr Ala Ile Trp Arg Leu Tyr 
305                 310                 315                 320 


Gly Arg Ser Thr Met Ala Leu Gln Gln Ala Gln Met Leu Leu Ser Met 
                325                 330                 335     


Asn Ser Leu Glu Ala Val Asn Ala Gly Val Gln Gln Asn Asn Thr Glu 
            340                 345                 350         


Ser Phe Ala Val Ala Leu Cys His Leu Ala Glu Leu His Ala Glu Gln 
        355                 360                 365             


Gly Cys Phe Ala Ala Ala Ser Glu Val Leu Lys His Leu Lys Glu Arg 
    370                 375                 380                 


Phe Pro Pro Asn Ser Gln His Ala Gln Leu Trp Met Leu Cys Asp Gln 
385                 390                 395                 400 


Lys Ile Gln Phe Asp Arg Ala Met Asn Asp Gly Lys Tyr His Leu Ala 
                405                 410                 415     


Asp Ser Leu Val Thr Gly Ile Thr Ala Leu Asn Ser Ile Glu Gly Val 
            420                 425                 430         


Tyr Arg Lys Ala Val Val Leu Gln Ala Gln Asn Gln Met Ser Glu Ala 
        435                 440                 445             


His Lys Leu Leu Gln Lys Leu Leu Val His Cys Gln Lys Leu Lys Asn 
    450                 455                 460                 


Thr Glu Met Val Ile Ser Val Leu Leu Ser Val Ala Glu Leu Tyr Trp 
465                 470                 475                 480 


Arg Ser Ser Ser Pro Thr Ile Ala Leu Pro Met Leu Leu Gln Ala Leu 
                485                 490                 495     


Ala Leu Ser Lys Glu Tyr Arg Leu Gln Tyr Leu Ala Ser Glu Thr Val 
            500                 505                 510         


Leu Asn Leu Ala Phe Ala Gln Leu Ile Leu Gly Ile Pro Glu Gln Ala 
        515                 520                 525             


Leu Ser Leu Leu His Met Ala Ile Glu Pro Ile Leu Ala Asp Gly Ala 
    530                 535                 540                 


Ile Leu Asp Lys Gly Arg Ala Met Phe Leu Val Ala Lys Cys Gln Val 
545                 550                 555                 560 


Ala Ser Ala Ala Ser Tyr Asp Gln Pro Lys Lys Ala Glu Ala Leu Glu 
                565                 570                 575     


Ala Ala Ile Glu Asn Leu Asn Glu Ala Lys Asn Tyr Phe Ala Lys Val 
            580                 585                 590         


Asp Cys Lys Glu Arg Ile Arg Asp Val Val Tyr Phe Gln Ala Arg Leu 
        595                 600                 605             


Tyr His Thr Leu Gly Lys Thr Gln Glu Arg Asn Arg Cys Ala Met Leu 
    610                 615                 620                 


Phe Arg Gln Leu His Gln Glu Leu Pro Ser His Gly Val Pro Leu Ile 
625                 630                 635                 640 


Asn His Leu 
            


<210>  514
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANAPC7__Homo_sapiens__NP_001131136

<400>  514

Met Asp Pro Gly Asp Ala Ala Ile Leu Glu Ser Ser Leu Arg Ile Leu 
1               5                   10                  15      


Tyr Arg Leu Phe Glu Ser Val Leu Pro Pro Leu Pro Ala Ala Leu Gln 
            20                  25                  30          


Ser Arg Met Asn Val Ile Asp His Val Arg Asp Met Ala Ala Ala Gly 
        35                  40                  45              


Leu His Ser Asn Val Arg Leu Leu Ser Ser Leu Leu Leu Thr Met Ser 
    50                  55                  60                  


Asn Asn Asn Pro Glu Leu Phe Ser Pro Pro Gln Lys Tyr Gln Leu Leu 
65                  70                  75                  80  


Val Tyr His Ala Asp Ser Leu Phe His Asp Lys Glu Tyr Arg Asn Ala 
                85                  90                  95      


Val Ser Lys Tyr Thr Met Ala Leu Gln Gln Lys Lys Ala Leu Ser Lys 
            100                 105                 110         


Thr Ser Lys Val Arg Pro Ser Thr Gly Asn Ser Ala Ser Thr Pro Gln 
        115                 120                 125             


Ser Gln Cys Leu Pro Ser Glu Ile Glu Val Lys Tyr Lys Met Ala Glu 
    130                 135                 140                 


Cys Tyr Thr Met Leu Lys Gln Asp Lys Asp Ala Ile Ala Ile Leu Asp 
145                 150                 155                 160 


Gly Ile Pro Ser Arg Gln Arg Thr Pro Lys Ile Asn Met Met Leu Ala 
                165                 170                 175     


Asn Leu Tyr Lys Lys Ala Gly Gln Glu Arg Pro Ser Val Thr Ser Tyr 
            180                 185                 190         


Lys Glu Val Leu Arg Gln Cys Pro Leu Ala Leu Asp Ala Ile Leu Gly 
        195                 200                 205             


Leu Leu Ser Leu Ser Val Lys Gly Ala Glu Val Ala Ser Met Thr Met 
    210                 215                 220                 


Asn Val Ile Gln Thr Val Pro Asn Leu Asp Trp Leu Ser Val Trp Ile 
225                 230                 235                 240 


Lys Ala Tyr Ala Phe Val His Thr Gly Asp Asn Ser Arg Ala Ile Ser 
                245                 250                 255     


Thr Ile Cys Ser Leu Glu Lys Lys Ser Leu Leu Arg Asp Asn Val Asp 
            260                 265                 270         


Leu Leu Gly Ser Leu Ala Asp Leu Tyr Phe Arg Ala Gly Asp Asn Lys 
        275                 280                 285             


Asn Ser Val Leu Lys Phe Glu Gln Ala Gln Met Leu Asp Pro Tyr Leu 
    290                 295                 300                 


Ile Lys Gly Met Asp Val Tyr Gly Tyr Leu Leu Ala Arg Glu Gly Arg 
305                 310                 315                 320 


Leu Glu Asp Val Glu Asn Leu Gly Cys Arg Leu Phe Asn Ile Ser Asp 
                325                 330                 335     


Gln His Ala Glu Pro Trp Val Val Ser Gly Cys His Ser Phe Tyr Ser 
            340                 345                 350         


Lys Arg Tyr Ser Arg Ala Leu Tyr Leu Gly Ala Lys Ala Ile Gln Leu 
        355                 360                 365             


Asn Ser Asn Ser Val Gln Ala Leu Leu Leu Lys Gly Ala Ala Leu Arg 
    370                 375                 380                 


Asn Met Gly Arg Val Gln Glu Ala Ile Ile His Phe Arg Glu Ala Ile 
385                 390                 395                 400 


Arg Leu Ala Pro Cys Arg Leu Asp Cys Tyr Glu Gly Leu Ile Glu Cys 
                405                 410                 415     


Tyr Leu Ala Ser Asn Ser Ile Arg Glu Ala Met Val Met Ala Asn Asn 
            420                 425                 430         


Val Tyr Lys Thr Leu Gly Ala Asn Ala Gln Thr Leu Thr Leu Leu Ala 
        435                 440                 445             


Thr Val Cys Leu Glu Asp Pro Val Thr Gln Glu Lys Ala Lys Thr Leu 
    450                 455                 460                 


Leu Asp Lys Ala Leu Thr Gln Arg Pro Asp Tyr Ile Lys Ala Val Val 
465                 470                 475                 480 


Lys Lys Ala Glu Leu Leu Ser Arg Glu Gln Lys Tyr Glu Asp Gly Ile 
                485                 490                 495     


Ala Leu Leu Arg Asn Ala Leu Ala Asn Gln Ser Asp Cys Val Leu His 
            500                 505                 510         


Arg Ile Leu Gly Asp Phe Leu Val Ala Val Asn Glu Tyr Gln Glu Ala 
        515                 520                 525             


Met Asp Gln Tyr Ser Ile Ala Leu Arg 
    530                 535         


<210>  515
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANG__Homo_sapiens__NP_001091046

<400>  515

Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210>  516
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPT1__Homo_sapiens__NP_001137

<400>  516

Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His 
1               5                   10                  15      


Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 
            20                  25                  30          


Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro 
        35                  40                  45              


Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr 
    50                  55                  60                  


Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser 
65                  70                  75                  80  


Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp 
                85                  90                  95      


Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 
            100                 105                 110         


Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu 
        115                 120                 125             


Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys 
    130                 135                 140                 


Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu 
145                 150                 155                 160 


Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln 
                165                 170                 175     


Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 
            180                 185                 190         


Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu 
        195                 200                 205             


Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr 
    210                 215                 220                 


Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 
225                 230                 235                 240 


Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 
                245                 250                 255     


Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu 
            260                 265                 270         


Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp 
        275                 280                 285             


Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile 
    290                 295                 300                 


Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn 
305                 310                 315                 320 


Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp 
                325                 330                 335     


Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser 
            340                 345                 350         


Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln 
        355                 360                 365             


Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg 
    370                 375                 380                 


Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn 
385                 390                 395                 400 


Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser 
                405                 410                 415     


Ser Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn 
            420                 425                 430         


Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp 
        435                 440                 445             


Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala 
    450                 455                 460                 


Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys 
465                 470                 475                 480 


Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu 
                485                 490                 495     


Asp Phe 
        


<210>  517
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPT2__Homo_sapiens__NP_001112359

<400>  517

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Lys Asp Pro Thr Val 
            260                 265                 270         


Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys 
        275                 280                 285             


Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser 
    290                 295                 300                 


Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg 
                325                 330                 335     


Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
            340                 345                 350         


Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr 
        355                 360                 365             


Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser 
    370                 375                 380                 


Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile 
385                 390                 395                 400 


His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser 
                405                 410                 415     


Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys 
            420                 425                 430         


Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala 
        435                 440                 445             


Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn 
    450                 455                 460                 


Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly 
465                 470                 475                 480 


Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495 


<210>  518
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPT4__Homo_sapiens__NP_057069

<400>  518

Met Leu Ser Gln Leu Ala Met Leu Gln Gly Ser Leu Leu Leu Val Val 
1               5                   10                  15      


Ala Thr Met Ser Val Ala Gln Gln Thr Arg Gln Glu Ala Asp Arg Gly 
            20                  25                  30          


Cys Glu Thr Leu Val Val Gln His Gly His Cys Ser Tyr Thr Phe Leu 
        35                  40                  45              


Leu Pro Lys Ser Glu Pro Cys Pro Pro Gly Pro Glu Val Ser Arg Asp 
    50                  55                  60                  


Ser Asn Thr Leu Gln Arg Glu Ser Leu Ala Asn Pro Leu His Leu Gly 
65                  70                  75                  80  


Lys Leu Pro Thr Gln Gln Val Lys Gln Leu Glu Gln Ala Leu Gln Asn 
                85                  90                  95      


Asn Thr Gln Trp Leu Lys Lys Leu Glu Arg Ala Ile Lys Thr Ile Leu 
            100                 105                 110         


Arg Ser Lys Leu Glu Gln Val Gln Gln Gln Met Ala Gln Asn Gln Thr 
        115                 120                 125             


Ala Pro Met Leu Glu Leu Gly Thr Ser Leu Leu Asn Gln Thr Thr Ala 
    130                 135                 140                 


Gln Ile Arg Lys Leu Thr Asp Met Glu Ala Gln Leu Leu Asn Gln Thr 
145                 150                 155                 160 


Ser Arg Met Asp Ala Gln Met Pro Glu Thr Phe Leu Ser Thr Asn Lys 
                165                 170                 175     


Leu Glu Asn Gln Leu Leu Leu Gln Arg Gln Lys Leu Gln Gln Leu Gln 
            180                 185                 190         


Gly Gln Asn Ser Ala Leu Glu Lys Arg Leu Gln Ala Leu Glu Thr Lys 
        195                 200                 205             


Gln Gln Glu Glu Leu Ala Ser Ile Leu Ser Lys Lys Ala Lys Leu Leu 
    210                 215                 220                 


Asn Thr Leu Ser Arg Gln Ser Ala Ala Leu Thr Asn Ile Glu Arg Gly 
225                 230                 235                 240 


Leu Arg Gly Val Arg His Asn Ser Ser Leu Leu Gln Asp Gln Gln His 
                245                 250                 255     


Ser Leu Arg Gln Leu Leu Val Leu Leu Arg His Leu Val Gln Glu Arg 
            260                 265                 270         


Ala Asn Ala Ser Ala Pro Ala Phe Ile Met Ala Gly Glu Gln Val Phe 
        275                 280                 285             


Gln Asp Cys Ala Glu Ile Gln Arg Ser Gly Ala Ser Ala Ser Gly Val 
    290                 295                 300                 


Tyr Thr Ile Gln Val Ser Asn Ala Thr Lys Pro Arg Lys Val Phe Cys 
305                 310                 315                 320 


Asp Leu Gln Ser Ser Gly Gly Arg Trp Thr Leu Ile Gln Arg Arg Glu 
                325                 330                 335     


Asn Gly Thr Val Asn Phe Gln Arg Asn Trp Lys Asp Tyr Lys Gln Gly 
            340                 345                 350         


Phe Gly Asp Pro Ala Gly Glu His Trp Leu Gly Asn Glu Val Val His 
        355                 360                 365             


Gln Leu Thr Arg Arg Ala Ala Tyr Ser Leu Arg Val Glu Leu Gln Asp 
    370                 375                 380                 


Trp Glu Gly His Glu Ala Tyr Ala Gln Tyr Glu His Phe His Leu Gly 
385                 390                 395                 400 


Ser Glu Asn Gln Leu Tyr Arg Leu Ser Val Val Gly Tyr Ser Gly Ser 
                405                 410                 415     


Ala Gly Arg Gln Ser Ser Leu Val Leu Gln Asn Thr Ser Phe Ser Thr 
            420                 425                 430         


Leu Asp Ser Asp Asn Asp His Cys Leu Cys Lys Cys Ala Gln Val Met 
        435                 440                 445             


Ser Gly Gly Trp Trp Phe Asp Ala Cys Gly Leu Ser Asn Leu Asn Gly 
    450                 455                 460                 


Val Tyr Tyr His Ala Pro Asp Asn Lys Tyr Lys Met Asp Gly Ile Arg 
465                 470                 475                 480 


Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ala Ser Arg Met 
                485                 490                 495     


Met Ile Arg Pro Leu Asp Ile 
            500             


<210>  519
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL1__Homo_sapiens__NP_004664

<400>  519

Met Lys Thr Phe Thr Trp Thr Leu Gly Val Leu Phe Phe Leu Leu Val 
1               5                   10                  15      


Asp Thr Gly His Cys Arg Gly Gly Gln Phe Lys Ile Lys Lys Ile Asn 
            20                  25                  30          


Gln Arg Arg Tyr Pro Arg Ala Thr Asp Gly Lys Glu Glu Ala Lys Lys 
        35                  40                  45              


Cys Ala Tyr Thr Phe Leu Val Pro Glu Gln Arg Ile Thr Gly Pro Ile 
    50                  55                  60                  


Cys Val Asn Thr Lys Gly Gln Asp Ala Ser Thr Ile Lys Asp Met Ile 
65                  70                  75                  80  


Thr Arg Met Asp Leu Glu Asn Leu Lys Asp Val Leu Ser Arg Gln Lys 
                85                  90                  95      


Arg Glu Ile Asp Val Leu Gln Leu Val Val Asp Val Asp Gly Asn Ile 
            100                 105                 110         


Val Asn Glu Val Lys Leu Leu Arg Lys Glu Ser Arg Asn Met Asn Ser 
        115                 120                 125             


Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu Ile Ile Arg Lys 
    130                 135                 140                 


Arg Asp Asn Ser Leu Glu Leu Ser Gln Leu Glu Asn Lys Ile Leu Asn 
145                 150                 155                 160 


Val Thr Thr Glu Met Leu Lys Met Ala Thr Arg Tyr Arg Glu Leu Glu 
                165                 170                 175     


Val Lys Tyr Ala Ser Leu Thr Asp Leu Val Asn Asn Gln Ser Val Met 
            180                 185                 190         


Ile Thr Leu Leu Glu Glu Gln Cys Leu Arg Ile Phe Ser Arg Gln Asp 
        195                 200                 205             


Thr His Val Ser Pro Pro Leu Val Gln Val Val Pro Gln His Ile Pro 
    210                 215                 220                 


Asn Ser Gln Gln Tyr Thr Pro Gly Leu Leu Gly Gly Asn Glu Ile Gln 
225                 230                 235                 240 


Arg Asp Pro Gly Tyr Pro Arg Asp Leu Met Pro Pro Pro Asp Leu Ala 
                245                 250                 255     


Thr Ser Pro Thr Lys Ser Pro Phe Lys Ile Pro Pro Val Thr Phe Ile 
            260                 265                 270         


Asn Glu Gly Pro Phe Lys Asp Cys Gln Gln Ala Lys Glu Ala Gly His 
        275                 280                 285             


Ser Val Ser Gly Ile Tyr Met Ile Lys Pro Glu Asn Ser Asn Gly Pro 
    290                 295                 300                 


Met Gln Leu Trp Cys Glu Asn Ser Leu Asp Pro Gly Gly Trp Thr Val 
305                 310                 315                 320 


Ile Gln Lys Arg Thr Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu 
                325                 330                 335     


Asn Tyr Lys Lys Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly 
            340                 345                 350         


Leu Glu Asn Ile Tyr Met Leu Ser Asn Gln Asp Asn Tyr Lys Leu Leu 
        355                 360                 365             


Ile Glu Leu Glu Asp Trp Ser Asp Lys Lys Val Tyr Ala Glu Tyr Ser 
    370                 375                 380                 


Ser Phe Arg Leu Glu Pro Glu Ser Glu Phe Tyr Arg Leu Arg Leu Gly 
385                 390                 395                 400 


Thr Tyr Gln Gly Asn Ala Gly Asp Ser Met Met Trp His Asn Gly Lys 
                405                 410                 415     


Gln Phe Thr Thr Leu Asp Arg Asp Lys Asp Met Tyr Ala Gly Asn Cys 
            420                 425                 430         


Ala His Phe His Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser 
        435                 440                 445             


Asn Leu Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Lys His 
    450                 455                 460                 


Gln Asp Gly Ile Phe Trp Ala Glu Tyr Arg Gly Gly Ser Tyr Ser Leu 
465                 470                 475                 480 


Arg Ala Val Gln Met Met Ile Lys Pro Ile Asp 
                485                 490     


<210>  520
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL2__Homo_sapiens__NP_036230

<400>  520

Met Arg Pro Leu Cys Val Thr Cys Trp Trp Leu Gly Leu Leu Ala Ala 
1               5                   10                  15      


Met Gly Ala Val Ala Gly Gln Glu Asp Gly Phe Glu Gly Thr Glu Glu 
            20                  25                  30          


Gly Ser Pro Arg Glu Phe Ile Tyr Leu Asn Arg Tyr Lys Arg Ala Gly 
        35                  40                  45              


Glu Ser Gln Asp Lys Cys Thr Tyr Thr Phe Ile Val Pro Gln Gln Arg 
    50                  55                  60                  


Val Thr Gly Ala Ile Cys Val Asn Ser Lys Glu Pro Glu Val Leu Leu 
65                  70                  75                  80  


Glu Asn Arg Val His Lys Gln Glu Leu Glu Leu Leu Asn Asn Glu Leu 
                85                  90                  95      


Leu Lys Gln Lys Arg Gln Ile Glu Thr Leu Gln Gln Leu Val Glu Val 
            100                 105                 110         


Asp Gly Gly Ile Val Ser Glu Val Lys Leu Leu Arg Lys Glu Ser Arg 
        115                 120                 125             


Asn Met Asn Ser Arg Val Thr Gln Leu Tyr Met Gln Leu Leu His Glu 
    130                 135                 140                 


Ile Ile Arg Lys Arg Asp Asn Ala Leu Glu Leu Ser Gln Leu Glu Asn 
145                 150                 155                 160 


Arg Ile Leu Asn Gln Thr Ala Asp Met Leu Gln Leu Ala Ser Lys Tyr 
                165                 170                 175     


Lys Asp Leu Glu His Lys Tyr Gln His Leu Ala Thr Leu Ala His Asn 
            180                 185                 190         


Gln Ser Glu Ile Ile Ala Gln Leu Glu Glu His Cys Gln Arg Val Pro 
        195                 200                 205             


Ser Ala Arg Pro Val Pro Gln Pro Pro Pro Ala Ala Pro Pro Arg Val 
    210                 215                 220                 


Tyr Gln Pro Pro Thr Tyr Asn Arg Ile Ile Asn Gln Ile Ser Thr Asn 
225                 230                 235                 240 


Glu Ile Gln Ser Asp Gln Asn Leu Lys Val Leu Pro Pro Pro Leu Pro 
                245                 250                 255     


Thr Met Pro Thr Leu Thr Ser Leu Pro Ser Ser Thr Asp Lys Pro Ser 
            260                 265                 270         


Gly Pro Trp Arg Asp Cys Leu Gln Ala Leu Glu Asp Gly His Asp Thr 
        275                 280                 285             


Ser Ser Ile Tyr Leu Val Lys Pro Glu Asn Thr Asn Arg Leu Met Gln 
    290                 295                 300                 


Val Trp Cys Asp Gln Arg His Asp Pro Gly Gly Trp Thr Val Ile Gln 
305                 310                 315                 320 


Arg Arg Leu Asp Gly Ser Val Asn Phe Phe Arg Asn Trp Glu Thr Tyr 
                325                 330                 335     


Lys Gln Gly Phe Gly Asn Ile Asp Gly Glu Tyr Trp Leu Gly Leu Glu 
            340                 345                 350         


Asn Ile Tyr Trp Leu Thr Asn Gln Gly Asn Tyr Lys Leu Leu Val Thr 
        355                 360                 365             


Met Glu Asp Trp Ser Gly Arg Lys Val Phe Ala Glu Tyr Ala Ser Phe 
    370                 375                 380                 


Arg Leu Glu Pro Glu Ser Glu Tyr Tyr Lys Leu Arg Leu Gly Arg Tyr 
385                 390                 395                 400 


His Gly Asn Ala Gly Asp Ser Phe Thr Trp His Asn Gly Lys Gln Phe 
                405                 410                 415     


Thr Thr Leu Asp Arg Asp His Asp Val Tyr Thr Gly Asn Cys Ala His 
            420                 425                 430         


Tyr Gln Lys Gly Gly Trp Trp Tyr Asn Ala Cys Ala His Ser Asn Leu 
        435                 440                 445             


Asn Gly Val Trp Tyr Arg Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp 
    450                 455                 460                 


Gly Val Tyr Trp Ala Glu Phe Arg Gly Gly Ser Tyr Ser Leu Lys Lys 
465                 470                 475                 480 


Val Val Met Met Ile Arg Pro Asn Pro Asn Thr Phe His 
                485                 490             


<210>  521
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL4__Homo_sapiens__NP_001034756

<400>  521

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His His Gly Gly Trp Thr Val Ile Gln Arg Arg 
            180                 185                 190         


His Asp Gly Ser Val Asp Phe Asn Arg Pro Trp Glu Ala Tyr Lys Ala 
        195                 200                 205             


Gly Phe Gly Asp Pro His Gly Glu Phe Trp Leu Gly Leu Glu Lys Val 
    210                 215                 220                 


His Ser Ile Thr Gly Asp Arg Asn Ser Arg Leu Ala Val Gln Leu Arg 
225                 230                 235                 240 


Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln Phe Ser Val His Leu Gly 
                245                 250                 255     


Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu Thr Ala Pro Val Ala Gly 
            260                 265                 270         


Gln Leu Gly Ala Thr Thr Val Pro Pro Ser Gly Leu Ser Val Pro Phe 
        275                 280                 285             


Ser Thr Trp Asp Gln Asp His Asp Leu Arg Arg Asp Lys Asn Cys Ala 
    290                 295                 300                 


Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly Thr Cys Ser His Ser Asn 
305                 310                 315                 320 


Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro Gln Gln Arg Gln Lys Leu 
                325                 330                 335     


Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg Gly Arg Tyr Tyr Pro Leu 
            340                 345                 350         


Gln Ala Thr Thr Met Leu Ile Gln Pro Met Ala Ala Glu Ala Ala Ser 
        355                 360                 365             


<210>  522
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANGPTL6__Homo_sapiens__NP_114123

<400>  522

Met Gly Lys Pro Trp Leu Arg Ala Leu Gln Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Ser Trp Ala Arg Ala Gly Ala Pro Arg Cys Thr Tyr Thr Phe Val 
            20                  25                  30          


Leu Pro Pro Gln Lys Phe Thr Gly Ala Val Cys Trp Ser Gly Pro Ala 
        35                  40                  45              


Ser Thr Arg Ala Thr Pro Glu Ala Ala Asn Ala Ser Glu Leu Ala Ala 
    50                  55                  60                  


Leu Arg Met Arg Val Gly Arg His Glu Glu Leu Leu Arg Glu Leu Gln 
65                  70                  75                  80  


Arg Leu Ala Ala Ala Asp Gly Ala Val Ala Gly Glu Val Arg Ala Leu 
                85                  90                  95      


Arg Lys Glu Ser Arg Gly Leu Ser Ala Arg Leu Gly Gln Leu Arg Ala 
            100                 105                 110         


Gln Leu Gln His Glu Ala Gly Pro Gly Ala Gly Pro Gly Ala Asp Leu 
        115                 120                 125             


Gly Ala Glu Pro Ala Ala Ala Leu Ala Leu Leu Gly Glu Arg Val Leu 
    130                 135                 140                 


Asn Ala Ser Ala Glu Ala Gln Arg Ala Ala Ala Arg Phe His Gln Leu 
145                 150                 155                 160 


Asp Val Lys Phe Arg Glu Leu Ala Gln Leu Val Thr Gln Gln Ser Ser 
                165                 170                 175     


Leu Ile Ala Arg Leu Glu Arg Leu Cys Pro Gly Gly Ala Gly Gly Gln 
            180                 185                 190         


Gln Gln Val Leu Pro Pro Pro Pro Leu Val Pro Val Val Pro Val Arg 
        195                 200                 205             


Leu Val Gly Ser Thr Ser Asp Thr Ser Arg Met Leu Asp Pro Ala Pro 
    210                 215                 220                 


Glu Pro Gln Arg Asp Gln Thr Gln Arg Gln Gln Glu Pro Met Ala Ser 
225                 230                 235                 240 


Pro Met Pro Ala Gly His Pro Ala Val Pro Thr Lys Pro Val Gly Pro 
                245                 250                 255     


Trp Gln Asp Cys Ala Glu Ala Arg Gln Ala Gly His Glu Gln Ser Gly 
            260                 265                 270         


Val Tyr Glu Leu Arg Val Gly Arg His Val Val Ser Val Trp Cys Glu 
        275                 280                 285             


Gln Gln Leu Glu Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Gln Asp 
    290                 295                 300                 


Gly Ser Val Asn Phe Phe Thr Thr Trp Gln His Tyr Lys Ala Gly Phe 
305                 310                 315                 320 


Gly Arg Pro Asp Gly Glu Tyr Trp Leu Gly Leu Glu Pro Val Tyr Gln 
                325                 330                 335     


Leu Thr Ser Arg Gly Asp His Glu Leu Leu Val Leu Leu Glu Asp Trp 
            340                 345                 350         


Gly Gly Arg Gly Ala Arg Ala His Tyr Asp Gly Phe Ser Leu Glu Pro 
        355                 360                 365             


Glu Ser Asp His Tyr Arg Leu Arg Leu Gly Gln Tyr His Gly Asp Ala 
    370                 375                 380                 


Gly Asp Ser Leu Ser Trp His Asn Asp Lys Pro Phe Ser Thr Val Asp 
385                 390                 395                 400 


Arg Asp Arg Asp Ser Tyr Ser Gly Asn Cys Ala Leu Tyr Gln Arg Gly 
                405                 410                 415     


Gly Trp Trp Tyr His Ala Cys Ala His Ser Asn Leu Asn Gly Val Trp 
            420                 425                 430         


His His Gly Gly His Tyr Arg Ser Arg Tyr Gln Asp Gly Val Tyr Trp 
        435                 440                 445             


Ala Glu Phe Arg Gly Gly Ala Tyr Ser Leu Arg Lys Ala Ala Met Leu 
    450                 455                 460                 


Ile Arg Pro Leu Lys Leu 
465                 470 


<210>  523
<211>  1880
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANK1__Homo_sapiens__NP_000028

<400>  523

Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      


Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          


Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              


Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  


Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      


Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         


Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             


Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 


Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 


Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     


Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         


Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             


Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 


Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 


Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     


Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         


Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             


Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 


Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 


Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     


Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         


Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             


Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 


Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 


Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     


Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         


Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             


His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 


Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 


Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     


Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         


Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             


Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 


Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 


His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     


Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         


Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             


Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 


Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 


Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     


Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         


His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             


Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 


Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 


Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     


Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         


Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             


Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 


Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 


Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     


Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         


Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             


Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 


Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 


Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     


Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         


Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             


Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 


Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 


Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     


Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         


Ile Pro His Phe Ala Ser His Gly  Arg Gly Asp Arg Glu  Leu Val Val 
        995                 1000                 1005             


Leu Arg  Ser Glu Asn Gly Ser  Val Trp Lys Glu His  Arg Ser Arg 
    1010                 1015                 1020             


Tyr Gly  Glu Ser Tyr Leu Asp  Gln Ile Leu Asn Gly  Met Asp Glu 
    1025                 1030                 1035             


Glu Leu  Gly Ser Leu Glu Glu  Leu Glu Lys Lys Arg  Val Cys Arg 
    1040                 1045                 1050             


Ile Ile  Thr Thr Asp Phe Pro  Leu Tyr Phe Val Ile  Met Ser Arg 
    1055                 1060                 1065             


Leu Cys  Gln Asp Tyr Asp Thr  Ile Gly Pro Glu Gly  Gly Ser Leu 
    1070                 1075                 1080             


Lys Ser  Lys Leu Val Pro Leu  Val Gln Ala Thr Phe  Pro Glu Asn 
    1085                 1090                 1095             


Ala Val  Thr Lys Arg Val Lys  Leu Ala Leu Gln Ala  Gln Pro Val 
    1100                 1105                 1110             


Pro Asp  Glu Leu Val Thr Lys  Leu Leu Gly Asn Gln  Ala Thr Phe 
    1115                 1120                 1125             


Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg Arg Lys  Phe His Arg 
    1130                 1135                 1140             


Pro Ile  Gly Leu Arg Ile Pro  Leu Pro Pro Ser Trp  Thr Asp Asn 
    1145                 1150                 1155             


Pro Arg  Asp Ser Gly Glu Gly  Asp Thr Thr Ser Leu  Arg Leu Leu 
    1160                 1165                 1170             


Cys Ser  Val Ile Gly Gly Thr  Asp Gln Ala Gln Trp  Glu Asp Ile 
    1175                 1180                 1185             


Thr Gly  Thr Thr Lys Leu Val  Tyr Ala Asn Glu Cys  Ala Asn Phe 
    1190                 1195                 1200             


Thr Thr  Asn Val Ser Ala Arg  Phe Trp Leu Ser Asp  Cys Pro Arg 
    1205                 1210                 1215             


Thr Ala  Glu Ala Val Asn Phe  Ala Thr Leu Leu Tyr  Lys Glu Leu 
    1220                 1225                 1230             


Thr Ala  Val Pro Tyr Met Ala  Lys Phe Val Ile Phe  Ala Lys Met 
    1235                 1240                 1245             


Asn Asp  Pro Arg Glu Gly Arg  Leu Arg Cys Tyr Cys  Met Thr Asp 
    1250                 1255                 1260             


Asp Lys  Val Asp Lys Thr Leu  Glu Gln His Glu Asn  Phe Val Glu 
    1265                 1270                 1275             


Val Ala  Arg Ser Arg Asp Ile  Glu Val Leu Glu Gly  Met Ser Leu 
    1280                 1285                 1290             


Phe Ala  Glu Leu Ser Gly Asn  Leu Val Pro Val Lys  Lys Ala Ala 
    1295                 1300                 1305             


Gln Gln  Arg Ser Phe His Phe  Gln Ser Phe Arg Glu  Asn Arg Leu 
    1310                 1315                 1320             


Ala Met  Pro Val Lys Val Arg  Asp Ser Ser Arg Glu  Pro Gly Gly 
    1325                 1330                 1335             


Ser Leu  Ser Phe Leu Arg Lys  Ala Met Lys Tyr Glu  Asp Thr Gln 
    1340                 1345                 1350             


His Ile  Leu Cys His Leu Asn  Ile Thr Met Pro Pro  Cys Ala Lys 
    1355                 1360                 1365             


Gly Ser  Gly Ala Glu Asp Arg  Arg Arg Thr Pro Thr  Pro Leu Ala 
    1370                 1375                 1380             


Leu Arg  Tyr Ser Ile Leu Ser  Glu Ser Thr Pro Gly  Ser Leu Ser 
    1385                 1390                 1395             


Gly Thr  Glu Gln Ala Glu Met  Lys Met Ala Val Ile  Ser Glu His 
    1400                 1405                 1410             


Leu Gly  Leu Ser Trp Ala Glu  Leu Ala Arg Glu Leu  Gln Phe Ser 
    1415                 1420                 1425             


Val Glu  Asp Ile Asn Arg Ile  Arg Val Glu Asn Pro  Asn Ser Leu 
    1430                 1435                 1440             


Leu Glu  Gln Ser Val Ala Leu  Leu Asn Leu Trp Val  Ile Arg Glu 
    1445                 1450                 1455             


Gly Gln  Asn Ala Asn Met Glu  Asn Leu Tyr Thr Ala  Leu Gln Ser 
    1460                 1465                 1470             


Ile Asp  Arg Gly Glu Ile Val  Asn Met Leu Glu Gly  Ser Gly Arg 
    1475                 1480                 1485             


Gln Ser  Arg Asn Leu Lys Pro  Asp Arg Arg His Thr  Asp Arg Asp 
    1490                 1495                 1500             


Tyr Ser  Leu Ser Pro Ser Gln  Met Asn Gly Tyr Ser  Ser Leu Gln 
    1505                 1510                 1515             


Asp Glu  Leu Leu Ser Pro Ala  Ser Leu Gly Cys Ala  Leu Ser Ser 
    1520                 1525                 1530             


Pro Leu  Arg Ala Asp Gln Tyr  Trp Asn Glu Val Ala  Val Leu Asp 
    1535                 1540                 1545             


Ala Ile  Pro Leu Ala Ala Thr  Glu His Asp Thr Met  Leu Glu Met 
    1550                 1555                 1560             


Ser Asp  Met Gln Val Trp Ser  Ala Gly Leu Thr Pro  Ser Leu Val 
    1565                 1570                 1575             


Thr Ala  Glu Asp Ser Ser Leu  Glu Cys Ser Lys Ala  Glu Asp Ser 
    1580                 1585                 1590             


Asp Ala  Thr Gly His Glu Trp  Lys Leu Glu Gly Ala  Leu Ser Glu 
    1595                 1600                 1605             


Glu Pro  Arg Gly Pro Glu Leu  Gly Ser Leu Glu Leu  Val Glu Asp 
    1610                 1615                 1620             


Asp Thr  Val Asp Ser Asp Ala  Thr Asn Gly Leu Ile  Asp Leu Leu 
    1625                 1630                 1635             


Glu Gln  Glu Glu Gly Gln Arg  Ser Glu Glu Lys Leu  Pro Gly Ser 
    1640                 1645                 1650             


Lys Arg  Gln Asp Asp Ala Thr  Gly Ala Gly Gln Asp  Ser Glu Asn 
    1655                 1660                 1665             


Glu Val  Ser Leu Val Ser Gly  His Gln Arg Gly Gln  Ala Arg Ile 
    1670                 1675                 1680             


Thr His  Ser Pro Thr Val Ser  Gln Val Thr Glu Arg  Ser Gln Asp 
    1685                 1690                 1695             


Arg Leu  Gln Asp Trp Asp Ala  Asp Gly Ser Ile Val  Ser Tyr Leu 
    1700                 1705                 1710             


Gln Asp  Ala Ala Gln Gly Ser  Trp Gln Glu Glu Val  Thr Gln Gly 
    1715                 1720                 1725             


Pro His  Ser Phe Gln Gly Thr  Ser Thr Met Thr Glu  Gly Leu Glu 
    1730                 1735                 1740             


Pro Gly  Gly Ser Gln Glu Tyr  Glu Lys Val Leu Val  Ser Val Ser 
    1745                 1750                 1755             


Glu His  Thr Trp Thr Glu Gln  Pro Glu Ala Glu Ser  Ser Gln Ala 
    1760                 1765                 1770             


Asp Arg  Asp Arg Arg Gln Gln  Gly Gln Glu Glu Gln  Val Gln Glu 
    1775                 1780                 1785             


Ala Lys  Asn Thr Phe Thr Gln  Val Val Gln Gly Asn  Glu Phe Gln 
    1790                 1795                 1800             


Asn Ile  Pro Gly Glu Gln Val  Thr Glu Glu Gln Phe  Thr Asp Glu 
    1805                 1810                 1815             


Gln Gly  Asn Ile Val Thr Lys  Lys Ile Ile Arg Lys  Val Val Arg 
    1820                 1825                 1830             


Gln Ile  Asp Leu Ser Ser Ala  Asp Ala Ala Gln Glu  His Glu Glu 
    1835                 1840                 1845             


Val Glu  Leu Arg Gly Ser Gly  Leu Gln Pro Asp Leu  Ile Glu Gly 
    1850                 1855                 1860             


Arg Lys  Gly Ala Gln Ile Val  Lys Arg Ala Ser Leu  Lys Arg Gly 
    1865                 1870                 1875             


Lys Gln  
    1880 


<210>  524
<211>  1863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANK2__Homo_sapiens__NP_001120965

<400>  524

Met Thr Thr Met Leu Gln Lys Ser Asp Ser Asn Ala Ser Phe Leu Arg 
1               5                   10                  15      


Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu Tyr Leu Lys Gly 
            20                  25                  30          


Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Ala Leu His 
        35                  40                  45              


Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln Glu Leu Leu Gly 
    50                  55                  60                  


Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys Gly Asn Thr Ala Leu 
65                  70                  75                  80  


His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val Lys Val Leu Val 
                85                  90                  95      


Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn Gly Phe Thr Pro 
            100                 105                 110         


Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu 
        115                 120                 125             


Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr Glu Asp Gly Phe Thr 
    130                 135                 140                 


Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His 
                165                 170                 175     


Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala Ala Leu Leu Leu Gln 
            180                 185                 190         


Asn Asp His Asn Ala Asp Val Gln Ser Lys Met Met Val Asn Arg Thr 
        195                 200                 205             


Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly Asn 
    210                 215                 220                 


Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly Ala Ala Val Asp Phe 
225                 230                 235                 240 


Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val Ala Ser Lys Arg Gly 
                245                 250                 255     


Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg Gly Gly Gln Ile Asp 
            260                 265                 270         


Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His Cys Ala Ala Arg Ser 
        275                 280                 285             


Gly His Asp Gln Val Val Glu Leu Leu Leu Glu Arg Gly Ala Pro Leu 
    290                 295                 300                 


Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu His Met Ala Ala Gln 
305                 310                 315                 320 


Gly Asp His Val Glu Cys Val Lys His Leu Leu Gln His Lys Ala Pro 
                325                 330                 335     


Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala Leu His Val Ala Ala 
            340                 345                 350         


His Cys Gly His Tyr Arg Val Thr Lys Leu Leu Leu Asp Lys Arg Ala 
        355                 360                 365             


Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr Pro Leu His Ile Ala 
    370                 375                 380                 


Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Val Lys Tyr Gly 
385                 390                 395                 400 


Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu Thr Pro Ile His Val 
                405                 410                 415     


Ala Ala Phe Met Gly His Leu Asn Ile Val Leu Leu Leu Leu Gln Asn 
            420                 425                 430         


Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly Glu Thr Ala Leu His 
        435                 440                 445             


Met Ala Ala Arg Ala Gly Gln Val Glu Val Val Arg Cys Leu Leu Arg 
    450                 455                 460                 


Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu Glu Gln Thr Pro Leu 
465                 470                 475                 480 


His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile Val Gln Leu Leu Leu 
                485                 490                 495     


Gln His Met Ala His Pro Asp Ala Ala Thr Thr Asn Gly Tyr Thr Pro 
            500                 505                 510         


Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp Val Ala Ser Val Leu 
        515                 520                 525             


Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr Lys Lys Gly Phe Thr 
    530                 535                 540                 


Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu Asp Val Ala Lys Leu 
545                 550                 555                 560 


Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly Lys Asn Gly Leu 
                565                 570                 575     


Thr Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala Leu 
            580                 585                 590         


Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala Thr Ala Lys Asn Gly 
        595                 600                 605             


Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Gln Ile Ala 
    610                 615                 620                 


Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn Ile Val Thr Lys Gln 
625                 630                 635                 640 


Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu Gly His Thr Asp Met 
                645                 650                 655     


Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile His Met Ser Thr Lys 
            660                 665                 670         


Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln Glu Asp Lys Val Asn 
        675                 680                 685             


Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp Gln Asp Ala His Thr 
    690                 695                 700                 


Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys His Tyr Gly Asn Val 
705                 710                 715                 720 


Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala Asn Val Asn Ala Lys 
                725                 730                 735     


Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala Ala Gln Gln Gly His 
            740                 745                 750         


Thr His Ile Ile Asn Val Leu Leu Gln His Gly Ala Lys Pro Asn Ala 
        755                 760                 765             


Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile Ala Lys Arg Leu Gly 
    770                 775                 780                 


Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val Thr Glu Glu Val Thr 
785                 790                 795                 800 


Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys Leu Asn Val Pro Glu 
                805                 810                 815     


Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Thr 
            820                 825                 830         


Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu 
        835                 840                 845             


Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn 
    850                 855                 860                 


Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser 
865                 870                 875                 880 


Phe Ser Ser Asp Arg Ser His Thr Leu Ser His Ala Ser Tyr Leu Arg 
                885                 890                 895     


Asp Ser Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val 
            900                 905                 910         


Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp 
        915                 920                 925             


Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His 
    930                 935                 940                 


Ser Gly Arg Ala Ser Pro Cys Leu Glu Arg Asp Asn Ser Ser Phe Leu 
945                 950                 955                 960 


Val Ser Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg Gly Cys Arg 
                965                 970                 975     


His Asn Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys Thr Ala Pro 
            980                 985                 990         


Thr Arg Val Thr Cys Arg Leu Val  Lys Arg His Arg Leu  Ala Thr Met 
        995                 1000                 1005             


Pro Pro  Met Val Glu Gly Glu  Gly Leu Ala Ser Arg  Leu Ile Glu 
    1010                 1015                 1020             


Val Gly  Pro Ser Gly Ala Gln  Phe Leu Gly Lys Leu  His Leu Pro 
    1025                 1030                 1035             


Thr Ala  Pro Pro Pro Leu Asn  Glu Gly Glu Ser Leu  Val Ser Arg 
    1040                 1045                 1050             


Ile Leu  Gln Leu Gly Pro Pro  Gly Thr Lys Phe Leu  Gly Pro Val 
    1055                 1060                 1065             


Ile Val  Glu Ile Pro His Phe  Ala Ala Leu Arg Gly  Lys Glu Arg 
    1070                 1075                 1080             


Glu Leu  Val Val Leu Arg Ser  Glu Asn Gly Asp Ser  Trp Lys Glu 
    1085                 1090                 1095             


His Phe  Cys Asp Tyr Thr Glu  Asp Glu Leu Asn Glu  Ile Leu Asn 
    1100                 1105                 1110             


Gly Met  Asp Glu Val Leu Asp  Ser Pro Glu Asp Leu  Glu Lys Lys 
    1115                 1120                 1125             


Arg Ile  Cys Arg Ile Ile Thr  Arg Asp Phe Pro Gln  Tyr Phe Ala 
    1130                 1135                 1140             


Val Val  Ser Arg Ile Lys Gln  Asp Ser Asn Leu Ile  Gly Pro Glu 
    1145                 1150                 1155             


Gly Gly  Val Leu Ser Ser Thr  Val Val Pro Gln Val  Gln Ala Val 
    1160                 1165                 1170             


Phe Pro  Glu Gly Ala Leu Thr  Lys Arg Ile Arg Val  Gly Leu Gln 
    1175                 1180                 1185             


Ala Gln  Pro Met His Ser Glu  Leu Val Lys Lys Ile  Leu Gly Asn 
    1190                 1195                 1200             


Lys Ala  Thr Phe Ser Pro Ile  Val Thr Leu Glu Pro  Arg Arg Arg 
    1205                 1210                 1215             


Lys Phe  His Lys Pro Ile Thr  Met Thr Ile Pro Val  Pro Lys Ala 
    1220                 1225                 1230             


Ser Ser  Asp Val Met Leu Asn  Gly Phe Gly Gly Asp  Ala Pro Thr 
    1235                 1240                 1245             


Leu Arg  Leu Leu Cys Ser Ile  Thr Gly Gly Thr Thr  Pro Ala Gln 
    1250                 1255                 1260             


Trp Glu  Asp Ile Thr Gly Thr  Thr Pro Leu Thr Phe  Val Asn Glu 
    1265                 1270                 1275             


Cys Val  Ser Phe Thr Thr Asn  Val Ser Ala Arg Phe  Trp Leu Ile 
    1280                 1285                 1290             


Asp Cys  Arg Gln Ile Gln Glu  Ser Val Thr Phe Ala  Ser Gln Val 
    1295                 1300                 1305             


Tyr Arg  Glu Ile Ile Cys Val  Pro Tyr Met Ala Lys  Phe Val Val 
    1310                 1315                 1320             


Phe Ala  Lys Ser His Asp Pro  Ile Glu Ala Arg Leu  Arg Cys Phe 
    1325                 1330                 1335             


Cys Met  Thr Asp Asp Lys Val  Asp Lys Thr Leu Glu  Gln Gln Glu 
    1340                 1345                 1350             


Asn Phe  Ala Glu Val Ala Arg  Ser Arg Asp Val Glu  Val Leu Glu 
    1355                 1360                 1365             


Gly Lys  Pro Ile Tyr Val Asp  Cys Phe Gly Asn Leu  Val Pro Leu 
    1370                 1375                 1380             


Thr Lys  Ser Gly Gln His His  Ile Phe Ser Phe Phe  Ala Phe Lys 
    1385                 1390                 1395             


Glu Asn  Arg Leu Pro Leu Phe  Val Lys Val Arg Asp  Thr Thr Gln 
    1400                 1405                 1410             


Glu Pro  Cys Gly Arg Leu Ser  Phe Met Lys Glu Pro  Lys Ser Thr 
    1415                 1420                 1425             


Arg Gly  Leu Val His Gln Ala  Ile Cys Asn Leu Asn  Ile Thr Leu 
    1430                 1435                 1440             


Pro Ile  Tyr Thr Lys Glu Ser  Glu Ser Asp Gln Glu  Gln Glu Glu 
    1445                 1450                 1455             


Glu Ile  Asp Met Thr Ser Glu  Lys Asn Pro Gln Asp  Glu Gln Glu 
    1460                 1465                 1470             


Arg Ile  Glu Glu Arg Leu Ala  Tyr Ile Ala Asp His  Leu Gly Phe 
    1475                 1480                 1485             


Ser Trp  Thr Glu Leu Ala Arg  Glu Leu Asp Phe Thr  Glu Glu Gln 
    1490                 1495                 1500             


Ile His  Gln Ile Arg Ile Glu  Asn Pro Asn Ser Leu  Gln Asp Gln 
    1505                 1510                 1515             


Ser His  Ala Leu Leu Lys Tyr  Trp Leu Glu Arg Asp  Gly Lys His 
    1520                 1525                 1530             


Ala Thr  Asp Thr Asn Leu Val  Glu Cys Leu Thr Lys  Ile Asn Arg 
    1535                 1540                 1545             


Met Asp  Ile Val His Leu Met  Glu Thr Asn Thr Glu  Pro Leu Gln 
    1550                 1555                 1560             


Glu Arg  Ile Ser His Ser Tyr  Ala Glu Ile Glu Gln  Thr Ile Thr 
    1565                 1570                 1575             


Leu Asp  His Ser Glu Gly Phe  Ser Val Leu Gln Glu  Glu Leu Cys 
    1580                 1585                 1590             


Thr Ala  Gln His Lys Gln Lys  Glu Glu Gln Ala Val  Ser Lys Glu 
    1595                 1600                 1605             


Ser Glu  Thr Cys Asp His Pro  Pro Ile Val Ser Glu  Glu Asp Ile 
    1610                 1615                 1620             


Ser Val  Gly Tyr Ser Thr Phe  Gln Asp Gly Val Pro  Lys Thr Glu 
    1625                 1630                 1635             


Gly Asp  Ser Ser Ala Thr Ala  Leu Phe Pro Gln Thr  His Lys Glu 
    1640                 1645                 1650             


Gln Val  Gln Gln Asp Phe Ser  Gly Lys Met Gln Asp  Leu Pro Glu 
    1655                 1660                 1665             


Glu Ser  Ser Leu Glu Tyr Gln  Gln Glu Tyr Phe Val  Thr Thr Pro 
    1670                 1675                 1680             


Gly Thr  Glu Thr Ser Glu Thr  Gln Lys Ala Met Ile  Val Pro Ser 
    1685                 1690                 1695             


Ser Pro  Ser Lys Thr Pro Glu  Glu Val Ser Thr Pro  Ala Glu Glu 
    1700                 1705                 1710             


Glu Lys  Leu Tyr Leu Gln Thr  Pro Thr Ser Ser Glu  Arg Gly Gly 
    1715                 1720                 1725             


Ser Pro  Ile Ile Gln Glu Pro  Glu Glu Pro Ser Glu  His Arg Glu 
    1730                 1735                 1740             


Glu Ser  Ser Pro Arg Lys Thr  Ser Leu Val Ile Val  Glu Ser Ala 
    1745                 1750                 1755             


Asp Asn  Gln Pro Glu Thr Cys  Glu Arg Leu Asp Glu  Asp Ala Ala 
    1760                 1765                 1770             


Phe Glu  Lys Gly Asp Asp Met  Pro Glu Ile Pro Pro  Glu Thr Val 
    1775                 1780                 1785             


Thr Glu  Glu Glu Tyr Ile Asp  Glu His Gly His Thr  Val Val Lys 
    1790                 1795                 1800             


Lys Val  Thr Arg Lys Ile Ile  Arg Arg Tyr Val Ser  Ser Glu Gly 
    1805                 1810                 1815             


Thr Glu  Lys Glu Glu Ile Met  Val Gln Gly Met Pro  Gln Glu Pro 
    1820                 1825                 1830             


Val Asn  Ile Glu Glu Gly Asp  Gly Tyr Ser Lys Val  Ile Lys Arg 
    1835                 1840                 1845             


Val Val  Leu Lys Ser Asp Thr  Glu Gln Ser Glu Asp  Asn Asn Glu 
    1850                 1855                 1860             


<210>  525
<211>  1861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANK3__Homo_sapiens__NP_001191332

<400>  525

Met Ala Ser Ser Ala Ser Ser Ser Pro Ala Gly Thr Glu Asp Ser Ala 
1               5                   10                  15      


Pro Ala Gln Gly Gly Phe Gly Ser Asp Tyr Ser Arg Ser Ser Arg Lys 
            20                  25                  30          


Ser Asp Ala Asn Ala Ser Tyr Leu Arg Ala Ala Arg Ala Gly His Leu 
        35                  40                  45              


Glu Lys Ala Leu Asp Tyr Ile Lys Asn Gly Val Asp Ile Asn Ile Cys 
    50                  55                  60                  


Asn Gln Asn Gly Leu Asn Ala Leu His Leu Ala Ser Lys Glu Gly His 
65                  70                  75                  80  


Val Glu Val Val Ser Glu Leu Leu Gln Arg Glu Ala Asn Val Asp Ala 
                85                  90                  95      


Ala Thr Lys Lys Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly 
            100                 105                 110         


Gln Ala Glu Val Val Lys Val Leu Val Thr Asn Gly Ala Asn Val Asn 
        115                 120                 125             


Ala Gln Ser Gln Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu 
    130                 135                 140                 


Asn His Leu Glu Val Val Lys Phe Leu Leu Asp Asn Gly Ala Ser Gln 
145                 150                 155                 160 


Ser Leu Ala Thr Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln 
                165                 170                 175     


Gln Gly His Asp Gln Val Val Ser Leu Leu Leu Glu Asn Asp Thr Lys 
            180                 185                 190         


Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp 
        195                 200                 205             


Thr Lys Ala Ala Ala Leu Leu Leu Gln Asn Asp Asn Asn Ala Asp Val 
    210                 215                 220                 


Glu Ser Lys Ser Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly 
225                 230                 235                 240 


Asn Ile Asn Val Ala Thr Leu Leu Leu Asn Arg Ala Ala Ala Val Asp 
                245                 250                 255     


Phe Thr Ala Arg Asn Asp Ile Thr Pro Leu His Val Ala Ser Lys Arg 
            260                 265                 270         


Gly Asn Ala Asn Met Val Lys Leu Leu Leu Asp Arg Gly Ala Lys Ile 
        275                 280                 285             


Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His Cys Gly Ala Arg 
    290                 295                 300                 


Ser Gly His Glu Gln Val Val Glu Met Leu Leu Asp Arg Ala Ala Pro 
305                 310                 315                 320 


Ile Leu Ser Lys Thr Lys Asn Gly Leu Ser Pro Leu His Met Ala Thr 
                325                 330                 335     


Gln Gly Asp His Leu Asn Cys Val Gln Leu Leu Leu Gln His Asn Val 
            340                 345                 350         


Pro Val Asp Asp Val Thr Asn Asp Tyr Leu Thr Ala Leu His Val Ala 
        355                 360                 365             


Ala His Cys Gly His Tyr Lys Val Ala Lys Val Leu Leu Asp Lys Lys 
    370                 375                 380                 


Ala Asn Pro Asn Ala Lys Ala Leu Asn Gly Phe Thr Pro Leu His Ile 
385                 390                 395                 400 


Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu Leu Leu Lys His 
                405                 410                 415     


Gly Ala Ser Ile Gln Ala Val Thr Glu Ser Gly Leu Thr Pro Ile His 
            420                 425                 430         


Val Ala Ala Phe Met Gly His Val Asn Ile Val Ser Gln Leu Met His 
        435                 440                 445             


His Gly Ala Ser Pro Asn Thr Thr Asn Val Arg Gly Glu Thr Ala Leu 
    450                 455                 460                 


His Met Ala Ala Arg Ser Gly Gln Ala Glu Val Val Arg Tyr Leu Val 
465                 470                 475                 480 


Gln Asp Gly Ala Gln Val Glu Ala Lys Ala Lys Asp Asp Gln Thr Pro 
                485                 490                 495     


Leu His Ile Ser Ala Arg Leu Gly Lys Ala Asp Ile Val Gln Gln Leu 
            500                 505                 510         


Leu Gln Gln Gly Ala Ser Pro Asn Ala Ala Thr Thr Ser Gly Tyr Thr 
        515                 520                 525             


Pro Leu His Leu Ser Ala Arg Glu Gly His Glu Asp Val Ala Ala Phe 
    530                 535                 540                 


Leu Leu Asp His Gly Ala Ser Leu Ser Ile Thr Thr Lys Lys Gly Phe 
545                 550                 555                 560 


Thr Pro Leu His Val Ala Ala Lys Tyr Gly Lys Leu Glu Val Ala Asn 
                565                 570                 575     


Leu Leu Leu Gln Lys Ser Ala Ser Pro Asp Ala Ala Gly Lys Ser Gly 
            580                 585                 590         


Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala 
        595                 600                 605             


Leu Leu Leu Leu Asp Gln Gly Ala Ser Pro His Ala Ala Ala Lys Asn 
    610                 615                 620                 


Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Asp Ile 
625                 630                 635                 640 


Ala Thr Thr Leu Leu Glu Tyr Gly Ala Asp Ala Asn Ala Val Thr Arg 
                645                 650                 655     


Gln Gly Ile Ala Ser Val His Leu Ala Ala Gln Glu Gly His Val Asp 
            660                 665                 670         


Met Val Ser Leu Leu Leu Gly Arg Asn Ala Asn Val Asn Leu Ser Asn 
        675                 680                 685             


Lys Ser Gly Leu Thr Pro Leu His Leu Ala Ala Gln Glu Asp Arg Val 
    690                 695                 700                 


Asn Val Ala Glu Val Leu Val Asn Gln Gly Ala His Val Asp Ala Gln 
705                 710                 715                 720 


Thr Lys Met Gly Tyr Thr Pro Leu His Val Gly Cys His Tyr Gly Asn 
                725                 730                 735     


Ile Lys Ile Val Asn Phe Leu Leu Gln His Ser Ala Lys Val Asn Ala 
            740                 745                 750         


Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala Ala Gln Gln Gly 
        755                 760                 765             


His Thr His Ile Ile Asn Val Leu Leu Gln Asn Asn Ala Ser Pro Asn 
    770                 775                 780                 


Glu Leu Thr Val Asn Gly Asn Thr Ala Leu Gly Ile Ala Arg Arg Leu 
785                 790                 795                 800 


Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Ile Val Thr Glu Glu Thr 
                805                 810                 815     


Met Thr Thr Thr Thr Val Thr Glu Lys His Lys Met Asn Val Pro Glu 
            820                 825                 830         


Thr Met Asn Glu Val Leu Asp Met Ser Asp Asp Glu Val Arg Lys Ala 
        835                 840                 845             


Asn Ala Pro Glu Met Leu Ser Asp Gly Glu Tyr Ile Ser Asp Val Glu 
    850                 855                 860                 


Glu Gly Glu Asp Ala Met Thr Gly Asp Thr Asp Lys Tyr Leu Gly Pro 
865                 870                 875                 880 


Gln Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ala Glu Gly Tyr 
                885                 890                 895     


Met Gly Phe Ser Leu Gly Ala Arg Ser Ala Ser Leu Arg Ser Phe Ser 
            900                 905                 910         


Ser Asp Arg Ser Tyr Thr Leu Asn Arg Ser Ser Tyr Ala Arg Asp Ser 
        915                 920                 925             


Met Met Ile Glu Glu Leu Leu Val Pro Ser Lys Glu Gln His Leu Thr 
    930                 935                 940                 


Phe Thr Arg Glu Phe Asp Ser Asp Ser Leu Arg His Tyr Ser Trp Ala 
945                 950                 955                 960 


Ala Asp Thr Leu Asp Asn Val Asn Leu Val Ser Ser Pro Ile His Ser 
                965                 970                 975     


Gly Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg 
            980                 985                 990         


Gly Ser Arg His His Gly Met Arg  Ile Ile Ile Pro Pro  Arg Lys Cys 
        995                 1000                 1005             


Thr Ala  Pro Thr Arg Ile Thr  Cys Arg Leu Val Lys  Arg His Lys 
    1010                 1015                 1020             


Leu Ala  Asn Pro Pro Pro Met  Val Glu Gly Glu Gly  Leu Ala Ser 
    1025                 1030                 1035             


Arg Leu  Val Glu Met Gly Pro  Ala Gly Ala Gln Phe  Leu Gly Pro 
    1040                 1045                 1050             


Val Ile  Val Glu Ile Pro His  Phe Gly Ser Met Arg  Gly Lys Glu 
    1055                 1060                 1065             


Arg Glu  Leu Ile Val Leu Arg  Ser Glu Asn Gly Glu  Thr Trp Lys 
    1070                 1075                 1080             


Glu His  Gln Phe Asp Ser Lys  Asn Glu Asp Leu Thr  Glu Leu Leu 
    1085                 1090                 1095             


Asn Gly  Met Asp Glu Glu Leu  Asp Ser Pro Glu Glu  Leu Gly Lys 
    1100                 1105                 1110             


Lys Arg  Ile Cys Arg Ile Ile  Thr Lys Asp Phe Pro  Gln Tyr Phe 
    1115                 1120                 1125             


Ala Val  Val Ser Arg Ile Lys  Gln Glu Ser Asn Gln  Ile Gly Pro 
    1130                 1135                 1140             


Glu Gly  Gly Ile Leu Ser Ser  Thr Thr Val Pro Leu  Val Gln Ala 
    1145                 1150                 1155             


Ser Phe  Pro Glu Gly Ala Leu  Thr Lys Arg Ile Arg  Val Gly Leu 
    1160                 1165                 1170             


Gln Ala  Gln Pro Val Pro Asp  Glu Ile Val Lys Lys  Ile Leu Gly 
    1175                 1180                 1185             


Asn Lys  Ala Thr Phe Ser Pro  Ile Val Thr Val Glu  Pro Arg Arg 
    1190                 1195                 1200             


Arg Lys  Phe His Lys Pro Ile  Thr Met Thr Ile Pro  Val Pro Pro 
    1205                 1210                 1215             


Pro Ser  Gly Glu Gly Val Ser  Asn Gly Tyr Lys Gly  Asp Thr Thr 
    1220                 1225                 1230             


Pro Asn  Leu Arg Leu Leu Cys  Ser Ile Thr Gly Gly  Thr Ser Pro 
    1235                 1240                 1245             


Ala Gln  Trp Glu Asp Ile Thr  Gly Thr Thr Pro Leu  Thr Phe Ile 
    1250                 1255                 1260             


Lys Asp  Cys Val Ser Phe Thr  Thr Asn Val Ser Ala  Arg Phe Trp 
    1265                 1270                 1275             


Leu Ala  Asp Cys His Gln Val  Leu Glu Thr Val Gly  Leu Ala Thr 
    1280                 1285                 1290             


Gln Leu  Tyr Arg Glu Leu Ile  Cys Val Pro Tyr Met  Ala Lys Phe 
    1295                 1300                 1305             


Val Val  Phe Ala Lys Met Asn  Asp Pro Val Glu Ser  Ser Leu Arg 
    1310                 1315                 1320             


Cys Phe  Cys Met Thr Asp Asp  Lys Val Asp Lys Thr  Leu Glu Gln 
    1325                 1330                 1335             


Gln Glu  Asn Phe Glu Glu Val  Ala Arg Ser Lys Asp  Ile Glu Val 
    1340                 1345                 1350             


Leu Glu  Gly Lys Pro Ile Tyr  Val Asp Cys Tyr Gly  Asn Leu Ala 
    1355                 1360                 1365             


Pro Leu  Thr Lys Gly Gly Gln  Gln Leu Val Phe Asn  Phe Tyr Ser 
    1370                 1375                 1380             


Phe Lys  Glu Asn Arg Leu Pro  Phe Ser Ile Lys Ile  Arg Asp Thr 
    1385                 1390                 1395             


Ser Gln  Glu Pro Cys Gly Arg  Leu Ser Phe Leu Lys  Glu Pro Lys 
    1400                 1405                 1410             


Thr Thr  Lys Gly Leu Pro Gln  Thr Ala Val Cys Asn  Leu Asn Ile 
    1415                 1420                 1425             


Thr Leu  Pro Ala His Lys Lys  Ile Glu Lys Thr Asp  Arg Arg Gln 
    1430                 1435                 1440             


Ser Phe  Ala Ser Leu Ala Leu  Arg Lys Arg Tyr Ser  Tyr Leu Thr 
    1445                 1450                 1455             


Glu Pro  Gly Met Ser Pro Gln  Ser Pro Cys Glu Arg  Thr Asp Ile 
    1460                 1465                 1470             


Arg Met  Ala Ile Val Ala Asp  His Leu Gly Leu Ser  Trp Thr Glu 
    1475                 1480                 1485             


Leu Ala  Arg Glu Leu Asn Phe  Ser Val Asp Glu Ile  Asn Gln Ile 
    1490                 1495                 1500             


Arg Val  Glu Asn Pro Asn Ser  Leu Ile Ser Gln Ser  Phe Met Leu 
    1505                 1510                 1515             


Leu Lys  Lys Trp Val Thr Arg  Asp Gly Lys Asn Ala  Thr Thr Asp 
    1520                 1525                 1530             


Ala Leu  Thr Ser Val Leu Thr  Lys Ile Asn Arg Ile  Asp Ile Val 
    1535                 1540                 1545             


Thr Leu  Leu Glu Gly Pro Ile  Phe Asp Tyr Gly Asn  Ile Ser Gly 
    1550                 1555                 1560             


Thr Arg  Ser Phe Ala Asp Glu  Asn Asn Val Phe His  Asp Pro Val 
    1565                 1570                 1575             


Asp Gly  Tyr Pro Ser Leu Gln  Val Glu Leu Glu Thr  Pro Thr Gly 
    1580                 1585                 1590             


Leu His  Tyr Thr Pro Pro Thr  Pro Phe Gln Gln Asp  Asp Tyr Phe 
    1595                 1600                 1605             


Ser Asp  Ile Ser Ser Ile Glu  Ser Pro Leu Arg Thr  Pro Ser Arg 
    1610                 1615                 1620             


Leu Ser  Asp Gly Leu Val Pro  Ser Gln Gly Asn Ile  Glu His Ser 
    1625                 1630                 1635             


Ala Asp  Gly Pro Pro Val Val  Thr Ala Glu Asp Ala  Ser Leu Glu 
    1640                 1645                 1650             


Asp Ser  Lys Leu Glu Asp Ser  Val Pro Leu Thr Glu  Met Pro Glu 
    1655                 1660                 1665             


Ala Val  Asp Val Asp Glu Ser  Gln Leu Glu Asn Val  Cys Leu Ser 
    1670                 1675                 1680             


Trp Gln  Asn Glu Thr Ser Ser  Gly Asn Leu Glu Ser  Cys Ala Gln 
    1685                 1690                 1695             


Ala Arg  Arg Val Thr Gly Gly  Leu Leu Asp Arg Leu  Asp Asp Ser 
    1700                 1705                 1710             


Pro Asp  Gln Cys Arg Asp Ser  Ile Thr Ser Tyr Leu  Lys Gly Glu 
    1715                 1720                 1725             


Ala Gly  Lys Phe Glu Ala Asn  Gly Ser His Thr Glu  Ile Thr Pro 
    1730                 1735                 1740             


Glu Ala  Lys Thr Lys Ser Tyr  Phe Pro Glu Ser Gln  Asn Asp Val 
    1745                 1750                 1755             


Gly Lys  Gln Ser Thr Lys Glu  Thr Leu Lys Pro Lys  Ile His Gly 
    1760                 1765                 1770             


Ser Gly  His Val Glu Glu Pro  Ala Ser Pro Leu Ala  Ala Tyr Gln 
    1775                 1780                 1785             


Lys Ser  Leu Glu Glu Thr Ser  Lys Leu Ile Ile Glu  Glu Thr Lys 
    1790                 1795                 1800             


Pro Cys  Val Pro Val Ser Met  Lys Lys Met Ser Arg  Thr Ser Pro 
    1805                 1810                 1815             


Ala Asp  Gly Lys Pro Arg Leu  Ser Leu His Glu Glu  Glu Gly Ser 
    1820                 1825                 1830             


Ser Gly  Ser Glu Gln Lys Gln  Gly Glu Gly Phe Lys  Val Lys Thr 
    1835                 1840                 1845             


Lys Lys  Glu Ile Arg His Val  Glu Lys Lys Ser His  Ser 
    1850                 1855                 1860     


<210>  526
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKFN1__Homo_sapiens__NP_694960

<400>  526

Met Glu Ala Ser Leu Thr Arg Arg Leu Leu Phe Lys Asp Arg His Phe 
1               5                   10                  15      


Thr Cys Ser Lys Ile Ile Gly Arg Arg Phe Ala Cys Phe Ala Gln Arg 
            20                  25                  30          


Leu Ser His Arg Arg Lys Gln Ser Gln Cys Asp Leu Leu Asn Glu Ser 
        35                  40                  45              


Thr Gly Gln Leu Pro Thr Thr Cys Ser Ser Ala Ala Ser Asn Ser Ile 
    50                  55                  60                  


Asn Trp Asn Cys Arg Val Lys Met Thr Gln Gln Met Gln Asn Leu His 
65                  70                  75                  80  


Leu Cys Gln Ser Lys Lys His Ser Ala Pro Ser Ser Pro Asn Ala Ala 
                85                  90                  95      


Lys Arg Leu Tyr Arg Asn Leu Ser Glu Lys Leu Lys Gly Ser His Ser 
            100                 105                 110         


Ser Phe Asp Glu Ala Tyr Phe Arg Thr Arg Thr Asp Arg Leu Ser Leu 
        115                 120                 125             


Arg Lys Thr Ser Val Asn Phe Gln Gly Asn Glu Ala Met Phe Glu Ala 
    130                 135                 140                 


Val Glu Gln Gln Asp Met Asp Ala Val Gln Ile Leu Leu Tyr Gln Tyr 
145                 150                 155                 160 


Thr Pro Glu Glu Leu Asp Leu Asn Thr Pro Asn Ser Glu Gly Leu Thr 
                165                 170                 175     


Pro Leu Asp Ile Ala Ile Met Thr Asn Asn Val Pro Ile Ala Arg Ile 
            180                 185                 190         


Leu Leu Arg Thr Gly Ala Arg Glu Ser Pro His Phe Val Ser Leu Glu 
        195                 200                 205             


Ser Arg Ala Met His Leu Asn Thr Leu Val Gln Glu Ala Gln Glu Arg 
    210                 215                 220                 


Val Ser Glu Leu Ser Ala Gln Val Glu Asn Glu Gly Phe Thr Leu Asp 
225                 230                 235                 240 


Asn Thr Glu Lys Glu Lys Gln Leu Lys Ala Trp Glu Trp Arg Tyr Arg 
                245                 250                 255     


Leu Tyr Arg Arg Met Lys Thr Gly Phe Glu His Ala Arg Ala Pro Glu 
            260                 265                 270         


Met Pro Thr Asn Val Cys Leu Met Val Thr Ser Ser Thr Ser Leu Thr 
        275                 280                 285             


Val Ser Phe Gln Glu Pro Leu Ser Val Asn Ala Ala Val Val Thr Arg 
    290                 295                 300                 


Tyr Lys Val Glu Trp Ser Met Ser Glu Asp Phe Ser Pro Leu Ala Gly 
305                 310                 315                 320 


Glu Ile Ile Met Asp Asn Leu Gln Thr Leu Arg Cys Thr Ile Thr Gly 
                325                 330                 335     


Leu Thr Met Gly Gln Gln Tyr Phe Val Gln Val Ser Ala Tyr Asn Met 
            340                 345                 350         


Lys Gly Trp Gly Pro Ala Gln Thr Thr Thr Pro Ala Cys Ala Ser Pro 
        355                 360                 365             


Ser Asn Trp Lys Asp Tyr Asp Asp Arg Glu Pro Arg His Lys Gly Gln 
    370                 375                 380                 


Ser Glu Val Leu Glu Gly Leu Leu Gln Gln Val Arg Ala Leu His Gln 
385                 390                 395                 400 


His Tyr Ser Cys Arg Glu Ser Thr Lys Leu Gln Thr Thr Gly Arg Lys 
                405                 410                 415     


Gln Ser Val Ser Arg Ser Leu Lys His Leu Phe His Ser Ser Asn Lys 
            420                 425                 430         


Phe Val Lys Thr Leu Lys Arg Gly Leu Tyr Ile Ala Val Ile Phe Tyr 
        435                 440                 445             


Tyr Lys Asp Asn Ile Leu Val Thr Asn Glu Asp Gln Val Pro Ile Val 
    450                 455                 460                 


Glu Ile Asp Asp Ser His Thr Ser Ser Ile Thr Gln Asp Phe Leu Trp 
465                 470                 475                 480 


Phe Thr Lys Leu Ser Cys Met Trp Glu Asp Ile Arg Trp Leu Arg Gln 
                485                 490                 495     


Ser Ile Pro Ile Ser Ser Ser Ser Ser Thr Val Leu Gln Thr Arg Gln 
            500                 505                 510         


Lys Met Leu Ala Ala Thr Ala Gln Leu Gln Asn Leu Leu Gly Thr His 
        515                 520                 525             


Asn Leu Gly Arg Val Tyr Tyr Glu Pro Ile Lys Asp Arg His Gly Asn 
    530                 535                 540                 


Ile Leu Ile Val Thr Ile Arg Glu Val Glu Met Leu Tyr Ser Phe Phe 
545                 550                 555                 560 


Asn Gly Lys Trp Met Gln Ile Ser Lys Leu Gln Ser Gln Arg Lys Ser 
                565                 570                 575     


Leu Ser Thr Pro Glu Glu Pro Thr Ala Leu Asp Ile Leu Leu Ile Thr 
            580                 585                 590         


Ile Gln Asp Ile Leu Ser Tyr His Lys Arg Ser His Gln Arg Leu Phe 
        595                 600                 605             


Pro Gly Leu Tyr Leu Gly Tyr Leu Lys Leu Cys Ser Ser Val Asp Gln 
    610                 615                 620                 


Ile Lys Val Leu Val Thr Gln Lys Leu Pro Asn Ile Leu Cys His Val 
625                 630                 635                 640 


Lys Ile Arg Glu Asn Asn Asn Ile Ser Arg Glu Glu Trp Glu Trp Ile 
                645                 650                 655     


Gln Lys Leu Ser Gly Ser Glu Ser Met Glu Ser Val Asp His Thr Ser 
            660                 665                 670         


Asp Cys Pro Met Gln Leu Phe Phe Tyr Glu Leu Gln Met Ala Val Lys 
        675                 680                 685             


Ala Leu Leu Gln Gln Ile Asn Ile Pro Leu His Gln Ala Arg Asn Phe 
    690                 695                 700                 


Arg Leu Tyr Thr Gln Glu Val Leu Glu Met Gly His Asn Val Ser Phe 
705                 710                 715                 720 


Leu Leu Leu Leu Pro Ala Ser Asp Asp Val Cys Thr Ala Pro Gly Gln 
                725                 730                 735     


Asn Asn Pro Tyr Thr Pro His Ser Gly Phe Leu Asn Leu Pro Leu Gln 
            740                 745                 750         


Met Phe Glu Leu Gly Ile Val Ala Cys Phe Thr 
        755                 760             


<210>  527
<211>  1170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKFY1__Homo_sapiens__NP_057460

<400>  527

Met Ala Glu Glu Glu Val Ala Lys Leu Glu Lys His Leu Met Leu Leu 
1               5                   10                  15      


Arg Gln Glu Tyr Val Lys Leu Gln Lys Lys Leu Ala Glu Thr Glu Lys 
            20                  25                  30          


Arg Cys Ala Leu Leu Ala Ala Gln Ala Asn Lys Glu Ser Ser Ser Glu 
        35                  40                  45              


Ser Phe Ile Ser Arg Leu Leu Ala Ile Val Ala Asp Leu Tyr Glu Gln 
    50                  55                  60                  


Glu Gln Tyr Ser Asp Leu Lys Ile Lys Val Gly Asp Arg His Ile Ser 
65                  70                  75                  80  


Ala His Lys Phe Val Leu Ala Ala Arg Ser Asp Ser Trp Ser Leu Ala 
                85                  90                  95      


Asn Leu Ser Ser Thr Lys Glu Leu Asp Leu Ser Asp Ala Asn Pro Glu 
            100                 105                 110         


Val Thr Met Thr Met Leu Arg Trp Ile Tyr Thr Asp Glu Leu Glu Phe 
        115                 120                 125             


Arg Glu Asp Asp Val Phe Leu Thr Glu Leu Met Lys Leu Ala Asn Arg 
    130                 135                 140                 


Phe Gln Leu Gln Leu Leu Arg Glu Arg Cys Glu Lys Gly Val Met Ser 
145                 150                 155                 160 


Leu Val Asn Val Arg Asn Cys Ile Arg Phe Tyr Gln Thr Ala Glu Glu 
                165                 170                 175     


Leu Asn Ala Ser Thr Leu Met Asn Tyr Cys Ala Glu Ile Ile Ala Ser 
            180                 185                 190         


His Trp Asp Asp Leu Arg Lys Glu Asp Phe Ser Ser Met Ser Ala Gln 
        195                 200                 205             


Leu Leu Tyr Lys Met Ile Lys Ser Lys Thr Glu Tyr Pro Leu His Lys 
    210                 215                 220                 


Ala Ile Lys Val Glu Arg Glu Asp Val Val Phe Leu Tyr Leu Ile Glu 
225                 230                 235                 240 


Met Asp Ser Gln Leu Pro Gly Lys Leu Asn Glu Ala Asp His Asn Gly 
                245                 250                 255     


Asp Leu Ala Leu Asp Leu Ala Leu Ser Arg Arg Leu Glu Ser Ile Ala 
            260                 265                 270         


Thr Thr Leu Val Ser His Lys Ala Asp Val Asp Met Val Asp Lys Ser 
        275                 280                 285             


Gly Trp Ser Leu Leu His Lys Gly Ile Gln Arg Gly Asp Leu Phe Ala 
    290                 295                 300                 


Ala Thr Phe Leu Ile Lys Asn Gly Ala Phe Val Asn Ala Ala Thr Leu 
305                 310                 315                 320 


Gly Ala Gln Glu Thr Pro Leu His Leu Val Ala Leu Tyr Ser Ser Lys 
                325                 330                 335     


Lys His Ser Ala Asp Val Met Ser Glu Met Ala Gln Ile Ala Glu Ala 
            340                 345                 350         


Leu Leu Gln Ala Gly Ala Asn Pro Asn Met Gln Asp Ser Lys Gly Arg 
        355                 360                 365             


Thr Pro Leu His Val Ser Ile Met Ala Gly Asn Glu Tyr Val Phe Ser 
    370                 375                 380                 


Gln Leu Leu Gln Cys Lys Gln Leu Asp Leu Glu Leu Lys Asp His Glu 
385                 390                 395                 400 


Gly Ser Thr Ala Leu Trp Leu Ala Val Gln His Ile Thr Val Ser Ser 
                405                 410                 415     


Asp Gln Ser Val Asn Pro Phe Glu Asp Val Pro Val Val Asn Gly Thr 
            420                 425                 430         


Ser Phe Asp Glu Asn Ser Phe Ala Ala Arg Leu Ile Gln Arg Gly Ser 
        435                 440                 445             


His Thr Asp Ala Pro Asp Thr Ala Thr Gly Asn Cys Leu Leu Gln Arg 
    450                 455                 460                 


Ala Ala Gly Ala Gly Asn Glu Ala Ala Ala Leu Phe Leu Ala Thr Asn 
465                 470                 475                 480 


Gly Ala His Val Asn His Arg Asn Lys Trp Gly Glu Thr Pro Leu His 
                485                 490                 495     


Thr Ala Cys Arg His Gly Leu Ala Asn Leu Thr Ala Glu Leu Leu Gln 
            500                 505                 510         


Gln Gly Ala Asn Pro Asn Leu Gln Thr Glu Glu Ala Leu Pro Leu Pro 
        515                 520                 525             


Lys Glu Ala Ala Ser Leu Thr Ser Leu Ala Asp Ser Val His Leu Gln 
    530                 535                 540                 


Thr Pro Leu His Met Ala Ile Ala Tyr Asn His Pro Asp Val Val Ser 
545                 550                 555                 560 


Val Ile Leu Glu Gln Lys Ala Asn Ala Leu His Ala Thr Asn Asn Leu 
                565                 570                 575     


Gln Ile Ile Pro Asp Phe Ser Leu Lys Asp Ser Arg Asp Gln Thr Val 
            580                 585                 590         


Leu Gly Leu Ala Leu Trp Thr Gly Met His Thr Ile Ala Ala Gln Leu 
        595                 600                 605             


Leu Gly Ser Gly Ala Ala Ile Asn Asp Thr Met Ser Asp Gly Gln Thr 
    610                 615                 620                 


Leu Leu His Met Ala Ile Gln Arg Gln Asp Ser Lys Ser Ala Leu Phe 
625                 630                 635                 640 


Leu Leu Glu His Gln Ala Asp Ile Asn Val Ser Arg Thr Gln Asp Gly 
                645                 650                 655     


Glu Thr Ala Leu Gln Leu Ala Ile Arg Asn Gln Leu Pro Leu Val Val 
            660                 665                 670         


Asp Ala Ile Cys Thr Arg Gly Ala Asp Met Ser Val Pro Asp Glu Lys 
        675                 680                 685             


Gly Asn Pro Pro Leu Trp Leu Ala Leu Ala Asn Asn Leu Glu Asp Ile 
    690                 695                 700                 


Ala Ser Thr Leu Val Arg His Gly Cys Asp Ala Thr Cys Trp Gly Pro 
705                 710                 715                 720 


Gly Pro Gly Gly Cys Leu Gln Thr Leu Leu His Arg Ala Ile Asp Glu 
                725                 730                 735     


Asn Asn Glu Pro Thr Ala Cys Phe Leu Ile Arg Ser Gly Cys Asp Val 
            740                 745                 750         


Asn Ser Pro Arg Gln Pro Gly Ala Asn Gly Glu Gly Glu Glu Glu Ala 
        755                 760                 765             


Arg Asp Gly Gln Thr Pro Leu His Leu Ala Ala Ser Trp Gly Leu Glu 
    770                 775                 780                 


Glu Thr Val Gln Cys Leu Leu Glu Phe Gly Ala Asn Val Asn Ala Gln 
785                 790                 795                 800 


Asp Ala Glu Gly Arg Thr Pro Ile His Val Ala Ile Ser Ser Gln His 
                805                 810                 815     


Gly Val Ile Ile Gln Leu Leu Val Ser His Pro Asp Ile His Leu Asn 
            820                 825                 830         


Val Arg Asp Arg Gln Gly Leu Thr Pro Phe Ala Cys Ala Met Thr Phe 
        835                 840                 845             


Lys Asn Asn Lys Ser Ala Glu Ala Ile Leu Lys Arg Glu Ser Gly Ala 
    850                 855                 860                 


Ala Glu Gln Val Asp Asn Lys Gly Arg Asn Phe Leu His Val Ala Val 
865                 870                 875                 880 


Gln Asn Ser Asp Ile Glu Ser Val Leu Phe Leu Ile Ser Val His Ala 
                885                 890                 895     


Asn Val Asn Ser Arg Val Gln Asp Ala Ser Lys Leu Thr Pro Leu His 
            900                 905                 910         


Leu Ala Val Gln Ala Gly Ser Glu Ile Ile Val Arg Asn Leu Leu Leu 
        915                 920                 925             


Ala Gly Ala Lys Val Asn Glu Leu Thr Lys His Arg Gln Thr Ala Leu 
    930                 935                 940                 


His Leu Ala Ala Gln Gln Asp Leu Pro Thr Ile Cys Ser Val Leu Leu 
945                 950                 955                 960 


Glu Asn Gly Val Asp Phe Ala Ala Val Asp Glu Asn Gly Asn Asn Ala 
                965                 970                 975     


Leu His Leu Ala Val Met His Gly Arg Leu Asn Asn Ile Arg Val Leu 
            980                 985                 990         


Leu Thr Glu Cys Thr Val Asp Ala  Glu Ala Phe Asn Leu  Arg Gly Gln 
        995                 1000                 1005             


Ser Pro  Leu His Ile Leu Gly  Gln Tyr Gly Lys Glu  Asn Ala Ala 
    1010                 1015                 1020             


Ala Ile  Phe Asp Leu Phe Leu  Glu Cys Met Pro Gly  Tyr Pro Leu 
    1025                 1030                 1035             


Asp Lys  Pro Asp Ala Asp Gly  Ser Thr Val Leu Leu  Leu Ala Tyr 
    1040                 1045                 1050             


Met Lys  Gly Asn Ala Asn Leu  Cys Arg Ala Ile Val  Arg Ser Gly 
    1055                 1060                 1065             


Ala Arg  Leu Gly Val Asn Asn  Asn Gln Gly Val Asn  Ile Phe Asn 
    1070                 1075                 1080             


Tyr Gln  Val Ala Thr Lys Gln  Leu Leu Phe Arg Leu  Leu Asp Met 
    1085                 1090                 1095             


Leu Ser  Lys Glu Pro Pro Trp  Cys Asp Gly Ser Tyr  Cys Tyr Glu 
    1100                 1105                 1110             


Cys Thr  Ala Arg Phe Gly Val  Thr Thr Arg Lys His  His Cys Arg 
    1115                 1120                 1125             


His Cys  Gly Arg Leu Leu Cys  His Lys Cys Ser Thr  Lys Glu Ile 
    1130                 1135                 1140             


Pro Ile  Ile Lys Phe Asp Leu  Asn Lys Pro Val Arg  Val Cys Asn 
    1145                 1150                 1155             


Ile Cys  Phe Asp Val Leu Thr  Leu Gly Gly Val Ser  
    1160                 1165                 1170 


<210>  528
<211>  2617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKHD1-EIF4EBP3__Homo_sapiens__NP_065741

<400>  528

Met Leu Thr Asp Ser Gly Gly Gly Gly Thr Ser Phe Glu Glu Asp Leu 
1               5                   10                  15      


Asp Ser Val Ala Pro Arg Ser Ala Pro Ala Gly Ala Ser Glu Pro Pro 
            20                  25                  30          


Pro Pro Gly Gly Val Gly Leu Gly Ile Arg Thr Val Arg Leu Phe Gly 
        35                  40                  45              


Glu Ala Gly Pro Ala Ser Gly Val Gly Ser Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Gly Gly Gly Asp Ala Ala Leu Asp Phe Lys Leu Ala 
65                  70                  75                  80  


Ala Ala Val Leu Arg Thr Gly Gly Gly Gly Gly Ala Ser Gly Ser Asp 
                85                  90                  95      


Glu Asp Glu Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Glu Asp 
            100                 105                 110         


Leu Asp Asn Pro Val Leu Lys Thr Thr Ser Glu Ile Phe Leu Ser Ser 
        115                 120                 125             


Thr Ala Glu Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala 
    130                 135                 140                 


Arg Leu Glu Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr 
145                 150                 155                 160 


Ala Asp Gly Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr 
                165                 170                 175     


Ser Ser Val Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg 
            180                 185                 190         


Met Lys Ala Glu Asn Ser His Asn Ala Gly Gln Val Asp Thr Arg Ser 
        195                 200                 205             


Leu Ala Glu Ala Cys Ser Asp Gly Asp Val Asn Ala Val Arg Lys Leu 
    210                 215                 220                 


Leu Asp Glu Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser 
225                 230                 235                 240 


Leu Leu Cys Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val 
                245                 250                 255     


Leu Leu Ala Met His Ala Asn Val Glu Asp Arg Gly Asn Lys Gly Asp 
            260                 265                 270         


Ile Thr Pro Leu Met Ala Ala Ser Ser Gly Gly Tyr Leu Asp Ile Val 
        275                 280                 285             


Lys Leu Leu Leu Leu His Asp Ala Asp Val Asn Ser Gln Ser Ala Thr 
    290                 295                 300                 


Gly Asn Thr Ala Leu Thr Tyr Ala Cys Ala Gly Gly Phe Val Asp Ile 
305                 310                 315                 320 


Val Lys Val Leu Leu Asn Glu Gly Ala Asn Ile Glu Asp His Asn Glu 
                325                 330                 335     


Asn Gly His Thr Pro Leu Met Glu Ala Ala Ser Ala Gly His Val Glu 
            340                 345                 350         


Val Ala Arg Val Leu Leu Asp His Gly Ala Gly Ile Asn Thr His Ser 
        355                 360                 365             


Asn Glu Phe Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His 
    370                 375                 380                 


Leu Asp Met Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His 
385                 390                 395                 400 


Lys Thr Asp Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly 
                405                 410                 415     


His Val Glu Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn 
            420                 425                 430         


Met Pro Ala Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly 
        435                 440                 445             


Gly His Val Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Asn Leu 
    450                 455                 460                 


Glu Glu Val Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg 
465                 470                 475                 480 


Glu Gly His Glu Glu Met Val Ala Leu Leu Leu Ala Gln Gly Ala Asn 
                485                 490                 495     


Ile Asn Ala Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala 
            500                 505                 510         


Cys Cys Gly Gly Phe Ser Glu Val Ala Asp Phe Leu Ile Lys Ala Gly 
        515                 520                 525             


Ala Asp Ile Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ser Gln 
    530                 535                 540                 


Glu Gly His Leu Glu Leu Val Lys Tyr Leu Leu Ala Ser Gly Ala Asn 
545                 550                 555                 560 


Val His Ala Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys 
                565                 570                 575     


Glu Asn Gly His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala 
            580                 585                 590         


Asp Leu Glu His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala 
        595                 600                 605             


Ala Arg Ala Gly His Leu Cys Thr Val Gln Phe Leu Ile Ser Lys Gly 
    610                 615                 620                 


Ala Asn Val Asn Arg Ala Thr Ala Asn Asn Asp His Thr Val Val Ser 
625                 630                 635                 640 


Leu Ala Cys Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala 
                645                 650                 655     


His Gly Ala Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu 
            660                 665                 670         


Ile Glu Ala Ala Lys Gly Gly His Thr Asn Val Val Ser Tyr Leu Leu 
        675                 680                 685             


Asp Tyr Pro Asn Asn Val Leu Ser Val Pro Thr Thr Asp Val Ser Gln 
    690                 695                 700                 


Leu Pro Pro Pro Ser Gln Asp Gln Ser Gln Val Pro Arg Val Pro Thr 
705                 710                 715                 720 


His Thr Leu Ala Met Val Val Pro Pro Gln Glu Pro Asp Arg Thr Ser 
                725                 730                 735     


Gln Glu Asn Ser Pro Ala Leu Leu Gly Val Gln Lys Gly Thr Ser Lys 
            740                 745                 750         


Gln Lys Ser Ser Ser Leu Gln Val Ala Asp Gln Asp Leu Leu Pro Ser 
        755                 760                 765             


Phe His Pro Tyr Gln Pro Leu Glu Cys Ile Val Glu Glu Thr Glu Gly 
    770                 775                 780                 


Lys Leu Asn Glu Leu Gly Gln Arg Ile Ser Ala Ile Glu Lys Ala Gln 
785                 790                 795                 800 


Leu Lys Ser Leu Glu Leu Ile Gln Gly Glu Pro Leu Asn Lys Asp Lys 
                805                 810                 815     


Ile Glu Glu Leu Lys Lys Asn Arg Glu Glu Gln Val Gln Lys Lys Lys 
            820                 825                 830         


Lys Ile Leu Lys Glu Leu Gln Lys Val Glu Arg Gln Leu Gln Met Lys 
        835                 840                 845             


Thr Gln Gln Gln Phe Thr Lys Glu Tyr Leu Glu Thr Lys Gly Gln Lys 
    850                 855                 860                 


Asp Thr Val Ser Leu His Gln Gln Cys Ser His Arg Gly Val Phe Pro 
865                 870                 875                 880 


Glu Gly Glu Gly Asp Gly Ser Leu Pro Glu Asp His Phe Ser Glu Leu 
                885                 890                 895     


Pro Gln Val Asp Thr Ile Leu Phe Lys Asp Asn Asp Val Asp Asp Glu 
            900                 905                 910         


Gln Gln Ser Pro Pro Ser Ala Glu Gln Ile Asp Phe Val Pro Val Gln 
        915                 920                 925             


Pro Leu Ser Ser Pro Gln Cys Asn Phe Ser Ser Asp Leu Gly Ser Asn 
    930                 935                 940                 


Gly Thr Asn Ser Leu Glu Leu Gln Lys Val Ser Gly Asn Gln Gln Ile 
945                 950                 955                 960 


Val Gly Gln Pro Gln Ile Ala Ile Thr Gly His Asp Gln Gly Leu Leu 
                965                 970                 975     


Val Gln Glu Pro Asp Gly Leu Met Val Ala Thr Pro Ala Gln Thr Leu 
            980                 985                 990         


Thr Asp Thr Leu Asp Asp Leu Ile  Ala Ala Val Ser Thr  Arg Val Pro 
        995                 1000                 1005             


Thr Gly  Ser Asn Ser Ser Ser  Gln Thr Thr Glu Cys  Leu Thr Pro 
    1010                 1015                 1020             


Glu Ser  Cys Ser Gln Thr Thr  Ser Asn Val Ala Ser  Gln Ser Met 
    1025                 1030                 1035             


Pro Pro  Val Tyr Pro Ser Val  Asp Ile Asp Ala His  Thr Glu Ser 
    1040                 1045                 1050             


Asn His  Asp Thr Ala Leu Thr  Leu Ala Cys Ala Gly  Gly His Glu 
    1055                 1060                 1065             


Glu Leu  Val Ser Val Leu Ile  Ala Arg Asp Ala Lys  Ile Glu His 
    1070                 1075                 1080             


Arg Asp  Lys Lys Gly Phe Thr  Pro Leu Ile Leu Ala  Ala Thr Ala 
    1085                 1090                 1095             


Gly His  Val Gly Val Val Glu  Ile Leu Leu Asp Lys  Gly Gly Asp 
    1100                 1105                 1110             


Ile Glu  Ala Gln Ser Glu Arg  Thr Lys Asp Thr Pro  Leu Ser Leu 
    1115                 1120                 1125             


Ala Cys  Ser Gly Gly Arg Gln  Glu Val Val Asp Leu  Leu Leu Ala 
    1130                 1135                 1140             


Arg Gly  Ala Asn Lys Glu His  Arg Asn Val Ser Asp  Tyr Thr Pro 
    1145                 1150                 1155             


Leu Ser  Leu Ala Ala Ser Gly  Gly Tyr Val Asn Ile  Ile Lys Ile 
    1160                 1165                 1170             


Leu Leu  Asn Ala Gly Ala Glu  Ile Asn Ser Arg Thr  Gly Ser Lys 
    1175                 1180                 1185             


Leu Gly  Ile Ser Pro Leu Met  Leu Ala Ala Met Asn  Gly His Val 
    1190                 1195                 1200             


Pro Ala  Val Lys Leu Leu Leu  Asp Met Gly Ser Asp  Ile Asn Ala 
    1205                 1210                 1215             


Gln Ile  Glu Thr Asn Arg Asn  Thr Ala Leu Thr Leu  Ala Cys Phe 
    1220                 1225                 1230             


Gln Gly  Arg Ala Glu Val Val  Ser Leu Leu Leu Asp  Arg Lys Ala 
    1235                 1240                 1245             


Asn Val  Glu His Arg Ala Lys  Thr Gly Leu Thr Pro  Leu Met Glu 
    1250                 1255                 1260             


Ala Ala  Ser Gly Gly Tyr Ala  Glu Val Gly Arg Val  Leu Leu Asp 
    1265                 1270                 1275             


Lys Gly  Ala Asp Val Asn Ala  Pro Pro Val Pro Ser  Ser Arg Asp 
    1280                 1285                 1290             


Thr Ala  Leu Thr Ile Ala Ala  Asp Lys Gly His Tyr  Lys Phe Cys 
    1295                 1300                 1305             


Glu Leu  Leu Ile His Arg Gly  Ala His Ile Asp Val  Arg Asn Lys 
    1310                 1315                 1320             


Lys Gly  Asn Thr Pro Leu Trp  Leu Ala Ser Asn Gly  Gly His Phe 
    1325                 1330                 1335             


Asp Val  Val Gln Leu Leu Val  Gln Ala Gly Ala Asp  Val Asp Ala 
    1340                 1345                 1350             


Ala Asp  Asn Arg Lys Ile Thr  Pro Leu Met Ser Ala  Phe Arg Lys 
    1355                 1360                 1365             


Gly His  Val Lys Val Val Gln  Tyr Leu Val Lys Glu  Val Asn Gln 
    1370                 1375                 1380             


Phe Pro  Ser Asp Ile Glu Cys  Met Arg Tyr Ile Ala  Thr Ile Thr 
    1385                 1390                 1395             


Asp Lys  Glu Leu Leu Lys Lys  Cys His Gln Cys Val  Glu Thr Ile 
    1400                 1405                 1410             


Val Lys  Ala Lys Asp Gln Gln  Ala Ala Glu Ala Asn  Lys Asn Ala 
    1415                 1420                 1425             


Ser Ile  Leu Leu Lys Glu Leu  Asp Leu Glu Lys Ser  Arg Glu Glu 
    1430                 1435                 1440             


Ser Arg  Lys Gln Ala Leu Ala  Ala Lys Arg Glu Lys  Arg Lys Glu 
    1445                 1450                 1455             


Lys Arg  Lys Lys Lys Lys Glu  Glu Gln Lys Arg Lys  Gln Glu Glu 
    1460                 1465                 1470             


Asp Glu  Glu Asn Lys Pro Lys  Glu Asn Ser Glu Leu  Pro Glu Asp 
    1475                 1480                 1485             


Glu Asp  Glu Glu Glu Asn Asp  Glu Asp Val Glu Gln  Glu Val Pro 
    1490                 1495                 1500             


Ile Glu  Pro Pro Ser Ala Thr  Thr Thr Thr Thr Ile  Gly Ile Ser 
    1505                 1510                 1515             


Ala Thr  Ser Ala Thr Phe Thr  Asn Val Phe Gly Lys  Lys Arg Ala 
    1520                 1525                 1530             


Asn Val  Val Thr Thr Pro Ser  Thr Asn Arg Lys Asn  Lys Lys Asn 
    1535                 1540                 1545             


Lys Thr  Lys Glu Thr Pro Pro  Thr Ala His Leu Ile  Leu Pro Glu 
    1550                 1555                 1560             


Gln His  Met Ser Leu Ala Gln  Gln Lys Ala Asp Lys  Asn Lys Ile 
    1565                 1570                 1575             


Asn Gly  Glu Pro Arg Gly Gly  Gly Ala Gly Gly Asn  Ser Asp Ser 
    1580                 1585                 1590             


Asp Asn  Leu Asp Ser Thr Asp  Cys Asn Ser Glu Ser  Ser Ser Gly 
    1595                 1600                 1605             


Gly Lys  Ser Gln Glu Leu Asn  Phe Val Met Asp Val  Asn Ser Ser 
    1610                 1615                 1620             


Lys Tyr  Pro Ser Leu Leu Leu  His Ser Gln Glu Glu  Lys Thr Ser 
    1625                 1630                 1635             


Thr Ala  Thr Ser Lys Thr Gln  Thr Arg Leu Glu Gly  Glu Val Thr 
    1640                 1645                 1650             


Pro Asn  Ser Leu Ser Thr Ser  Tyr Lys Thr Val Ser  Leu Pro Leu 
    1655                 1660                 1665             


Ser Ser  Pro Asn Ile Lys Leu  Asn Leu Thr Ser Pro  Lys Arg Gly 
    1670                 1675                 1680             


Gln Lys  Arg Glu Glu Gly Trp  Lys Glu Val Val Arg  Arg Ser Lys 
    1685                 1690                 1695             


Lys Leu  Ser Val Pro Ala Ser  Val Val Ser Arg Ile  Met Gly Arg 
    1700                 1705                 1710             


Gly Gly  Cys Asn Ile Thr Ala  Ile Gln Asp Val Thr  Gly Ala His 
    1715                 1720                 1725             


Ile Asp  Val Asp Lys Gln Lys  Asp Lys Asn Gly Glu  Arg Met Ile 
    1730                 1735                 1740             


Thr Ile  Arg Gly Gly Thr Glu  Ser Thr Arg Tyr Ala  Val Gln Leu 
    1745                 1750                 1755             


Ile Asn  Ala Leu Ile Gln Asp  Pro Ala Lys Glu Leu  Glu Asp Leu 
    1760                 1765                 1770             


Ile Pro  Lys Asn His Ile Arg  Thr Pro Ala Ser Thr  Lys Ser Ile 
    1775                 1780                 1785             


His Ala  Asn Phe Ser Ser Gly  Val Gly Thr Thr Ala  Ala Ser Ser 
    1790                 1795                 1800             


Lys Asn  Ala Phe Pro Leu Gly  Ala Pro Thr Leu Val  Thr Ser Gln 
    1805                 1810                 1815             


Ala Thr  Thr Leu Ser Thr Phe  Gln Pro Ala Asn Lys  Leu Asn Lys 
    1820                 1825                 1830             


Asn Val  Pro Thr Asn Val Arg  Ser Ser Phe Pro Val  Ser Leu Pro 
    1835                 1840                 1845             


Leu Ala  Tyr Pro His Pro His  Phe Ala Leu Leu Ala  Ala Gln Thr 
    1850                 1855                 1860             


Met Gln  Gln Ile Arg His Pro  Arg Leu Pro Met Ala  Gln Phe Gly 
    1865                 1870                 1875             


Gly Thr  Phe Ser Pro Ser Pro  Asn Thr Trp Gly Pro  Phe Pro Val 
    1880                 1885                 1890             


Arg Pro  Val Asn Pro Gly Asn  Thr Asn Ser Ser Pro  Lys His Asn 
    1895                 1900                 1905             


Asn Thr  Ser Arg Leu Pro Asn  Gln Asn Gly Thr Val  Leu Pro Ser 
    1910                 1915                 1920             


Glu Ser  Ala Gly Leu Ala Thr  Ala Ser Cys Pro Ile  Thr Val Ser 
    1925                 1930                 1935             


Ser Val  Val Ala Ala Ser Gln  Gln Leu Cys Val Thr  Asn Thr Arg 
    1940                 1945                 1950             


Thr Pro  Ser Ser Val Arg Lys  Gln Leu Phe Ala Cys  Val Pro Lys 
    1955                 1960                 1965             


Thr Ser  Pro Pro Ala Thr Val  Ile Ser Ser Val Thr  Ser Thr Cys 
    1970                 1975                 1980             


Ser Ser  Leu Pro Ser Val Ser  Ser Ala Pro Ile Thr  Ser Gly Gln 
    1985                 1990                 1995             


Ala Pro  Thr Thr Phe Leu Pro  Ala Ser Thr Ser Gln  Ala Gln Leu 
    2000                 2005                 2010             


Ser Ser  Gln Lys Met Glu Ser  Phe Ser Ala Val Pro  Pro Thr Lys 
    2015                 2020                 2025             


Glu Lys  Val Ser Thr Gln Asp  Gln Pro Met Ala Asn  Leu Cys Thr 
    2030                 2035                 2040             


Pro Ser  Ser Thr Ala Asn Ser  Cys Ser Ser Ser Ala  Ser Asn Thr 
    2045                 2050                 2055             


Pro Gly  Ala Pro Glu Thr His  Pro Ser Ser Ser Pro  Thr Pro Thr 
    2060                 2065                 2070             


Ser Ser  Asn Thr Gln Glu Glu  Ala Gln Pro Ser Ser  Val Ser Asp 
    2075                 2080                 2085             


Leu Ser  Pro Met Ser Met Pro  Phe Ala Ser Asn Ser  Glu Pro Ala 
    2090                 2095                 2100             


Pro Leu  Thr Leu Thr Ser Pro  Arg Met Val Ala Ala  Asp Asn Gln 
    2105                 2110                 2115             


Asp Thr  Ser Asn Leu Pro Gln  Leu Ala Val Pro Ala  Pro Arg Val 
    2120                 2125                 2130             


Ser His  Arg Met Gln Pro Arg  Gly Ser Phe Tyr Ser  Met Val Pro 
    2135                 2140                 2145             


Asn Ala  Thr Ile His Gln Asp  Pro Gln Ser Ile Phe  Val Thr Asn 
    2150                 2155                 2160             


Pro Val  Thr Leu Thr Pro Pro  Gln Gly Pro Pro Ala  Ala Val Gln 
    2165                 2170                 2175             


Leu Ser  Ser Ala Val Asn Ile  Met Asn Gly Ser Gln  Met His Ile 
    2180                 2185                 2190             


Asn Pro  Ala Asn Lys Ser Leu  Pro Pro Thr Phe Gly  Pro Ala Thr 
    2195                 2200                 2205             


Leu Phe  Asn His Phe Ser Ser  Leu Phe Asp Ser Ser  Gln Val Pro 
    2210                 2215                 2220             


Ala Asn  Gln Gly Trp Gly Asp  Gly Pro Leu Ser Ser  Arg Val Ala 
    2225                 2230                 2235             


Thr Asp  Ala Ser Phe Thr Val  Gln Ser Ala Phe Leu  Gly Asn Ser 
    2240                 2245                 2250             


Val Leu  Gly His Leu Glu Asn  Met His Pro Asp Asn  Ser Lys Ala 
    2255                 2260                 2265             


Pro Gly  Phe Arg Pro Pro Ser  Gln Arg Val Ser Thr  Ser Pro Val 
    2270                 2275                 2280             


Gly Leu  Pro Ser Ile Asp Pro  Ser Gly Ser Ser Pro  Ser Ser Ser 
    2285                 2290                 2295             


Ser Ala  Pro Leu Ala Ser Phe  Ser Gly Ile Pro Gly  Thr Arg Val 
    2300                 2305                 2310             


Phe Leu  Gln Gly Pro Ala Pro  Val Gly Thr Pro Ser  Phe Asn Arg 
    2315                 2320                 2325             


Gln His  Phe Ser Pro His Pro  Trp Thr Ser Ala Ser  Asn Ser Ser 
    2330                 2335                 2340             


Thr Ser  Ala Pro Pro Thr Leu  Gly Gln Pro Lys Gly  Val Ser Ala 
    2345                 2350                 2355             


Ser Gln  Asp Arg Lys Ile Pro  Pro Pro Ile Gly Thr  Glu Arg Leu 
    2360                 2365                 2370             


Ala Arg  Ile Arg Gln Gly Gly  Ser Val Ala Gln Ala  Pro Ala Gly 
    2375                 2380                 2385             


Thr Ser  Phe Val Ala Pro Val  Gly His Ser Gly Ile  Trp Ser Phe 
    2390                 2395                 2400             


Gly Val  Asn Ala Val Ser Glu  Gly Leu Ser Gly Trp  Ser Gln Ser 
    2405                 2410                 2415             


Val Met  Gly Asn His Pro Met  His Gln Gln Leu Ser  Asp Pro Ser 
    2420                 2425                 2430             


Thr Phe  Ser Gln His Gln Pro  Met Glu Arg Asp Asp  Ser Gly Met 
    2435                 2440                 2445             


Val Ala  Pro Ser Asn Ile Phe  His Gln Pro Met Ala  Ser Gly Phe 
    2450                 2455                 2460             


Val Asp  Phe Ser Lys Gly Leu  Pro Ile Ser Met Tyr  Gly Gly Thr 
    2465                 2470                 2475             


Ile Ile  Pro Ser His Pro Gln  Leu Ala Asp Val Pro  Gly Gly Pro 
    2480                 2485                 2490             


Leu Phe  Asn Gly Leu His Asn  Pro Asp Pro Ala Trp  Asn Pro Met 
    2495                 2500                 2505             


Ile Lys  Val Ile Gln Asn Ser  Thr Glu Cys Thr Asp  Ala Gln Gln 
    2510                 2515                 2520             


Ala Ser  Leu Leu Pro Ser Val  Pro Ala Leu Lys Gly  Glu Ile Pro 
    2525                 2530                 2535             


Ser Pro  Gln Leu Thr Arg Pro  Lys Lys Arg Ile Gly  Arg Pro Met 
    2540                 2545                 2550             


Val Ala  Ser Pro Asn Gln Arg  His Gln Asp His Leu  Arg Pro Lys 
    2555                 2560                 2565             


Val Pro  Ala Gly Val Gln Glu  Leu Thr His Cys Pro  Asp Thr Pro 
    2570                 2575                 2580             


Leu Leu  Pro Pro Ser Asp Ser  Arg Gly His Asn Ser  Ser Asn Ser 
    2585                 2590                 2595             


Pro Ser  Leu Gln Ala Gly Gly  Ala Glu Gly Ala Gly  Asp Arg Gly 
    2600                 2605                 2610             


Arg Asp  Thr Arg 
    2615         


<210>  529
<211>  2542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKHD1__Homo_sapiens__NP_060217

<400>  529

Met Leu Thr Asp Ser Gly Gly Gly Gly Thr Ser Phe Glu Glu Asp Leu 
1               5                   10                  15      


Asp Ser Val Ala Pro Arg Ser Ala Pro Ala Gly Ala Ser Glu Pro Pro 
            20                  25                  30          


Pro Pro Gly Gly Val Gly Leu Gly Ile Arg Thr Val Arg Leu Phe Gly 
        35                  40                  45              


Glu Ala Gly Pro Ala Ser Gly Val Gly Ser Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Gly Gly Gly Asp Ala Ala Leu Asp Phe Lys Leu Ala 
65                  70                  75                  80  


Ala Ala Val Leu Arg Thr Gly Gly Gly Gly Gly Ala Ser Gly Ser Asp 
                85                  90                  95      


Glu Asp Glu Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Glu Asp 
            100                 105                 110         


Leu Asp Asn Pro Val Leu Lys Thr Thr Ser Glu Ile Phe Leu Ser Ser 
        115                 120                 125             


Thr Ala Glu Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala 
    130                 135                 140                 


Arg Leu Glu Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr 
145                 150                 155                 160 


Ala Asp Gly Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr 
                165                 170                 175     


Ser Ser Val Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg 
            180                 185                 190         


Met Lys Ala Glu Asn Ser His Asn Ala Gly Gln Val Asp Thr Arg Ser 
        195                 200                 205             


Leu Ala Glu Ala Cys Ser Asp Gly Asp Val Asn Ala Val Arg Lys Leu 
    210                 215                 220                 


Leu Asp Glu Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser 
225                 230                 235                 240 


Leu Leu Cys Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val 
                245                 250                 255     


Leu Leu Ala Met His Ala Asn Val Glu Asp Arg Gly Asn Lys Gly Asp 
            260                 265                 270         


Ile Thr Pro Leu Met Ala Ala Ser Ser Gly Gly Tyr Leu Asp Ile Val 
        275                 280                 285             


Lys Leu Leu Leu Leu His Asp Ala Asp Val Asn Ser Gln Ser Ala Thr 
    290                 295                 300                 


Gly Asn Thr Ala Leu Thr Tyr Ala Cys Ala Gly Gly Phe Val Asp Ile 
305                 310                 315                 320 


Val Lys Val Leu Leu Asn Glu Gly Ala Asn Ile Glu Asp His Asn Glu 
                325                 330                 335     


Asn Gly His Thr Pro Leu Met Glu Ala Ala Ser Ala Gly His Val Glu 
            340                 345                 350         


Val Ala Arg Val Leu Leu Asp His Gly Ala Gly Ile Asn Thr His Ser 
        355                 360                 365             


Asn Glu Phe Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His 
    370                 375                 380                 


Leu Asp Met Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His 
385                 390                 395                 400 


Lys Thr Asp Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly 
                405                 410                 415     


His Val Glu Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn 
            420                 425                 430         


Met Pro Ala Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly 
        435                 440                 445             


Gly His Val Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Asn Leu 
    450                 455                 460                 


Glu Glu Val Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg 
465                 470                 475                 480 


Glu Gly His Glu Glu Met Val Ala Leu Leu Leu Ala Gln Gly Ala Asn 
                485                 490                 495     


Ile Asn Ala Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala 
            500                 505                 510         


Cys Cys Gly Gly Phe Ser Glu Val Ala Asp Phe Leu Ile Lys Ala Gly 
        515                 520                 525             


Ala Asp Ile Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ser Gln 
    530                 535                 540                 


Glu Gly His Leu Glu Leu Val Lys Tyr Leu Leu Ala Ser Gly Ala Asn 
545                 550                 555                 560 


Val His Ala Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys 
                565                 570                 575     


Glu Asn Gly His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala 
            580                 585                 590         


Asp Leu Glu His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala 
        595                 600                 605             


Ala Arg Ala Gly His Leu Cys Thr Val Gln Phe Leu Ile Ser Lys Gly 
    610                 615                 620                 


Ala Asn Val Asn Arg Ala Thr Ala Asn Asn Asp His Thr Val Val Ser 
625                 630                 635                 640 


Leu Ala Cys Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala 
                645                 650                 655     


His Gly Ala Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu 
            660                 665                 670         


Ile Glu Ala Ala Lys Gly Gly His Thr Asn Val Val Ser Tyr Leu Leu 
        675                 680                 685             


Asp Tyr Pro Asn Asn Val Leu Ser Val Pro Thr Thr Asp Val Ser Gln 
    690                 695                 700                 


Leu Pro Pro Pro Ser Gln Asp Gln Ser Gln Val Pro Arg Val Pro Thr 
705                 710                 715                 720 


His Thr Leu Ala Met Val Val Pro Pro Gln Glu Pro Asp Arg Thr Ser 
                725                 730                 735     


Gln Glu Asn Ser Pro Ala Leu Leu Gly Val Gln Lys Gly Thr Ser Lys 
            740                 745                 750         


Gln Lys Ser Ser Ser Leu Gln Val Ala Asp Gln Asp Leu Leu Pro Ser 
        755                 760                 765             


Phe His Pro Tyr Gln Pro Leu Glu Cys Ile Val Glu Glu Thr Glu Gly 
    770                 775                 780                 


Lys Leu Asn Glu Leu Gly Gln Arg Ile Ser Ala Ile Glu Lys Ala Gln 
785                 790                 795                 800 


Leu Lys Ser Leu Glu Leu Ile Gln Gly Glu Pro Leu Asn Lys Asp Lys 
                805                 810                 815     


Ile Glu Glu Leu Lys Lys Asn Arg Glu Glu Gln Val Gln Lys Lys Lys 
            820                 825                 830         


Lys Ile Leu Lys Glu Leu Gln Lys Val Glu Arg Gln Leu Gln Met Lys 
        835                 840                 845             


Thr Gln Gln Gln Phe Thr Lys Glu Tyr Leu Glu Thr Lys Gly Gln Lys 
    850                 855                 860                 


Asp Thr Val Ser Leu His Gln Gln Cys Ser His Arg Gly Val Phe Pro 
865                 870                 875                 880 


Glu Gly Glu Gly Asp Gly Ser Leu Pro Glu Asp His Phe Ser Glu Leu 
                885                 890                 895     


Pro Gln Val Asp Thr Ile Leu Phe Lys Asp Asn Asp Val Asp Asp Glu 
            900                 905                 910         


Gln Gln Ser Pro Pro Ser Ala Glu Gln Ile Asp Phe Val Pro Val Gln 
        915                 920                 925             


Pro Leu Ser Ser Pro Gln Cys Asn Phe Ser Ser Asp Leu Gly Ser Asn 
    930                 935                 940                 


Gly Thr Asn Ser Leu Glu Leu Gln Lys Val Ser Gly Asn Gln Gln Ile 
945                 950                 955                 960 


Val Gly Gln Pro Gln Ile Ala Ile Thr Gly His Asp Gln Gly Leu Leu 
                965                 970                 975     


Val Gln Glu Pro Asp Gly Leu Met Val Ala Thr Pro Ala Gln Thr Leu 
            980                 985                 990         


Thr Asp Thr Leu Asp Asp Leu Ile  Ala Ala Val Ser Thr  Arg Val Pro 
        995                 1000                 1005             


Thr Gly  Ser Asn Ser Ser Ser  Gln Thr Thr Glu Cys  Leu Thr Pro 
    1010                 1015                 1020             


Glu Ser  Cys Ser Gln Thr Thr  Ser Asn Val Ala Ser  Gln Ser Met 
    1025                 1030                 1035             


Pro Pro  Val Tyr Pro Ser Val  Asp Ile Asp Ala His  Thr Glu Ser 
    1040                 1045                 1050             


Asn His  Asp Thr Ala Leu Thr  Leu Ala Cys Ala Gly  Gly His Glu 
    1055                 1060                 1065             


Glu Leu  Val Ser Val Leu Ile  Ala Arg Asp Ala Lys  Ile Glu His 
    1070                 1075                 1080             


Arg Asp  Lys Lys Gly Phe Thr  Pro Leu Ile Leu Ala  Ala Thr Ala 
    1085                 1090                 1095             


Gly His  Val Gly Val Val Glu  Ile Leu Leu Asp Lys  Gly Gly Asp 
    1100                 1105                 1110             


Ile Glu  Ala Gln Ser Glu Arg  Thr Lys Asp Thr Pro  Leu Ser Leu 
    1115                 1120                 1125             


Ala Cys  Ser Gly Gly Arg Gln  Glu Val Val Asp Leu  Leu Leu Ala 
    1130                 1135                 1140             


Arg Gly  Ala Asn Lys Glu His  Arg Asn Val Ser Asp  Tyr Thr Pro 
    1145                 1150                 1155             


Leu Ser  Leu Ala Ala Ser Gly  Gly Tyr Val Asn Ile  Ile Lys Ile 
    1160                 1165                 1170             


Leu Leu  Asn Ala Gly Ala Glu  Ile Asn Ser Arg Thr  Gly Ser Lys 
    1175                 1180                 1185             


Leu Gly  Ile Ser Pro Leu Met  Leu Ala Ala Met Asn  Gly His Val 
    1190                 1195                 1200             


Pro Ala  Val Lys Leu Leu Leu  Asp Met Gly Ser Asp  Ile Asn Ala 
    1205                 1210                 1215             


Gln Ile  Glu Thr Asn Arg Asn  Thr Ala Leu Thr Leu  Ala Cys Phe 
    1220                 1225                 1230             


Gln Gly  Arg Ala Glu Val Val  Ser Leu Leu Leu Asp  Arg Lys Ala 
    1235                 1240                 1245             


Asn Val  Glu His Arg Ala Lys  Thr Gly Leu Thr Pro  Leu Met Glu 
    1250                 1255                 1260             


Ala Ala  Ser Gly Gly Tyr Ala  Glu Val Gly Arg Val  Leu Leu Asp 
    1265                 1270                 1275             


Lys Gly  Ala Asp Val Asn Ala  Pro Pro Val Pro Ser  Ser Arg Asp 
    1280                 1285                 1290             


Thr Ala  Leu Thr Ile Ala Ala  Asp Lys Gly His Tyr  Lys Phe Cys 
    1295                 1300                 1305             


Glu Leu  Leu Ile His Arg Gly  Ala His Ile Asp Val  Arg Asn Lys 
    1310                 1315                 1320             


Lys Gly  Asn Thr Pro Leu Trp  Leu Ala Ser Asn Gly  Gly His Phe 
    1325                 1330                 1335             


Asp Val  Val Gln Leu Leu Val  Gln Ala Gly Ala Asp  Val Asp Ala 
    1340                 1345                 1350             


Ala Asp  Asn Arg Lys Ile Thr  Pro Leu Met Ser Ala  Phe Arg Lys 
    1355                 1360                 1365             


Gly His  Val Lys Val Val Gln  Tyr Leu Val Lys Glu  Val Asn Gln 
    1370                 1375                 1380             


Phe Pro  Ser Asp Ile Glu Cys  Met Arg Tyr Ile Ala  Thr Ile Thr 
    1385                 1390                 1395             


Asp Lys  Glu Leu Leu Lys Lys  Cys His Gln Cys Val  Glu Thr Ile 
    1400                 1405                 1410             


Val Lys  Ala Lys Asp Gln Gln  Ala Ala Glu Ala Asn  Lys Asn Ala 
    1415                 1420                 1425             


Ser Ile  Leu Leu Lys Glu Leu  Asp Leu Glu Lys Ser  Arg Glu Glu 
    1430                 1435                 1440             


Ser Arg  Lys Gln Ala Leu Ala  Ala Lys Arg Glu Lys  Arg Lys Glu 
    1445                 1450                 1455             


Lys Arg  Lys Lys Lys Lys Glu  Glu Gln Lys Arg Lys  Gln Glu Glu 
    1460                 1465                 1470             


Asp Glu  Glu Asn Lys Pro Lys  Glu Asn Ser Glu Leu  Pro Glu Asp 
    1475                 1480                 1485             


Glu Asp  Glu Glu Glu Asn Asp  Glu Asp Val Glu Gln  Glu Val Pro 
    1490                 1495                 1500             


Ile Glu  Pro Pro Ser Ala Thr  Thr Thr Thr Thr Ile  Gly Ile Ser 
    1505                 1510                 1515             


Ala Thr  Ser Ala Thr Phe Thr  Asn Val Phe Gly Lys  Lys Arg Ala 
    1520                 1525                 1530             


Asn Val  Val Thr Thr Pro Ser  Thr Asn Arg Lys Asn  Lys Lys Asn 
    1535                 1540                 1545             


Lys Thr  Lys Glu Thr Pro Pro  Thr Ala His Leu Ile  Leu Pro Glu 
    1550                 1555                 1560             


Gln His  Met Ser Leu Ala Gln  Gln Lys Ala Asp Lys  Asn Lys Ile 
    1565                 1570                 1575             


Asn Gly  Glu Pro Arg Gly Gly  Gly Ala Gly Gly Asn  Ser Asp Ser 
    1580                 1585                 1590             


Asp Asn  Leu Asp Ser Thr Asp  Cys Asn Ser Glu Ser  Ser Ser Gly 
    1595                 1600                 1605             


Gly Lys  Ser Gln Glu Leu Asn  Phe Val Met Asp Val  Asn Ser Ser 
    1610                 1615                 1620             


Lys Tyr  Pro Ser Leu Leu Leu  His Ser Gln Glu Glu  Lys Thr Ser 
    1625                 1630                 1635             


Thr Ala  Thr Ser Lys Thr Gln  Thr Arg Leu Glu Gly  Glu Val Thr 
    1640                 1645                 1650             


Pro Asn  Ser Leu Ser Thr Ser  Tyr Lys Thr Val Ser  Leu Pro Leu 
    1655                 1660                 1665             


Ser Ser  Pro Asn Ile Lys Leu  Asn Leu Thr Ser Pro  Lys Arg Gly 
    1670                 1675                 1680             


Gln Lys  Arg Glu Glu Gly Trp  Lys Glu Val Val Arg  Arg Ser Lys 
    1685                 1690                 1695             


Lys Leu  Ser Val Pro Ala Ser  Val Val Ser Arg Ile  Met Gly Arg 
    1700                 1705                 1710             


Gly Gly  Cys Asn Ile Thr Ala  Ile Gln Asp Val Thr  Gly Ala His 
    1715                 1720                 1725             


Ile Asp  Val Asp Lys Gln Lys  Asp Lys Asn Gly Glu  Arg Met Ile 
    1730                 1735                 1740             


Thr Ile  Arg Gly Gly Thr Glu  Ser Thr Arg Tyr Ala  Val Gln Leu 
    1745                 1750                 1755             


Ile Asn  Ala Leu Ile Gln Asp  Pro Ala Lys Glu Leu  Glu Asp Leu 
    1760                 1765                 1770             


Ile Pro  Lys Asn His Ile Arg  Thr Pro Ala Ser Thr  Lys Ser Ile 
    1775                 1780                 1785             


His Ala  Asn Phe Ser Ser Gly  Val Gly Thr Thr Ala  Ala Ser Ser 
    1790                 1795                 1800             


Lys Asn  Ala Phe Pro Leu Gly  Ala Pro Thr Leu Val  Thr Ser Gln 
    1805                 1810                 1815             


Ala Thr  Thr Leu Ser Thr Phe  Gln Pro Ala Asn Lys  Leu Asn Lys 
    1820                 1825                 1830             


Asn Val  Pro Thr Asn Val Arg  Ser Ser Phe Pro Val  Ser Leu Pro 
    1835                 1840                 1845             


Leu Ala  Tyr Pro His Pro His  Phe Ala Leu Leu Ala  Ala Gln Thr 
    1850                 1855                 1860             


Met Gln  Gln Ile Arg His Pro  Arg Leu Pro Met Ala  Gln Phe Gly 
    1865                 1870                 1875             


Gly Thr  Phe Ser Pro Ser Pro  Asn Thr Trp Gly Pro  Phe Pro Val 
    1880                 1885                 1890             


Arg Pro  Val Asn Pro Gly Asn  Thr Asn Ser Ser Pro  Lys His Asn 
    1895                 1900                 1905             


Asn Thr  Ser Arg Leu Pro Asn  Gln Asn Gly Thr Val  Leu Pro Ser 
    1910                 1915                 1920             


Glu Ser  Ala Gly Leu Ala Thr  Ala Ser Cys Pro Ile  Thr Val Ser 
    1925                 1930                 1935             


Ser Val  Val Ala Ala Ser Gln  Gln Leu Cys Val Thr  Asn Thr Arg 
    1940                 1945                 1950             


Thr Pro  Ser Ser Val Arg Lys  Gln Leu Phe Ala Cys  Val Pro Lys 
    1955                 1960                 1965             


Thr Ser  Pro Pro Ala Thr Val  Ile Ser Ser Val Thr  Ser Thr Cys 
    1970                 1975                 1980             


Ser Ser  Leu Pro Ser Val Ser  Ser Ala Pro Ile Thr  Ser Gly Gln 
    1985                 1990                 1995             


Ala Pro  Thr Thr Phe Leu Pro  Ala Ser Thr Ser Gln  Ala Gln Leu 
    2000                 2005                 2010             


Ser Ser  Gln Lys Met Glu Ser  Phe Ser Ala Val Pro  Pro Thr Lys 
    2015                 2020                 2025             


Glu Lys  Val Ser Thr Gln Asp  Gln Pro Met Ala Asn  Leu Cys Thr 
    2030                 2035                 2040             


Pro Ser  Ser Thr Ala Asn Ser  Cys Ser Ser Ser Ala  Ser Asn Thr 
    2045                 2050                 2055             


Pro Gly  Ala Pro Glu Thr His  Pro Ser Ser Ser Pro  Thr Pro Thr 
    2060                 2065                 2070             


Ser Ser  Asn Thr Gln Glu Glu  Ala Gln Pro Ser Ser  Val Ser Asp 
    2075                 2080                 2085             


Leu Ser  Pro Met Ser Met Pro  Phe Ala Ser Asn Ser  Glu Pro Ala 
    2090                 2095                 2100             


Pro Leu  Thr Leu Thr Ser Pro  Arg Met Val Ala Ala  Asp Asn Gln 
    2105                 2110                 2115             


Asp Thr  Ser Asn Leu Pro Gln  Leu Ala Val Pro Ala  Pro Arg Val 
    2120                 2125                 2130             


Ser His  Arg Met Gln Pro Arg  Gly Ser Phe Tyr Ser  Met Val Pro 
    2135                 2140                 2145             


Asn Ala  Thr Ile His Gln Asp  Pro Gln Ser Ile Phe  Val Thr Asn 
    2150                 2155                 2160             


Pro Val  Thr Leu Thr Pro Pro  Gln Gly Pro Pro Ala  Ala Val Gln 
    2165                 2170                 2175             


Leu Ser  Ser Ala Val Asn Ile  Met Asn Gly Ser Gln  Met His Ile 
    2180                 2185                 2190             


Asn Pro  Ala Asn Lys Ser Leu  Pro Pro Thr Phe Gly  Pro Ala Thr 
    2195                 2200                 2205             


Leu Phe  Asn His Phe Ser Ser  Leu Phe Asp Ser Ser  Gln Val Pro 
    2210                 2215                 2220             


Ala Asn  Gln Gly Trp Gly Asp  Gly Pro Leu Ser Ser  Arg Val Ala 
    2225                 2230                 2235             


Thr Asp  Ala Ser Phe Thr Val  Gln Ser Ala Phe Leu  Gly Asn Ser 
    2240                 2245                 2250             


Val Leu  Gly His Leu Glu Asn  Met His Pro Asp Asn  Ser Lys Ala 
    2255                 2260                 2265             


Pro Gly  Phe Arg Pro Pro Ser  Gln Arg Val Ser Thr  Ser Pro Val 
    2270                 2275                 2280             


Gly Leu  Pro Ser Ile Asp Pro  Ser Gly Ser Ser Pro  Ser Ser Ser 
    2285                 2290                 2295             


Ser Ala  Pro Leu Ala Ser Phe  Ser Gly Ile Pro Gly  Thr Arg Val 
    2300                 2305                 2310             


Phe Leu  Gln Gly Pro Ala Pro  Val Gly Thr Pro Ser  Phe Asn Arg 
    2315                 2320                 2325             


Gln His  Phe Ser Pro His Pro  Trp Thr Ser Ala Ser  Asn Ser Ser 
    2330                 2335                 2340             


Thr Ser  Ala Pro Pro Thr Leu  Gly Gln Pro Lys Gly  Val Ser Ala 
    2345                 2350                 2355             


Ser Gln  Asp Arg Lys Ile Pro  Pro Pro Ile Gly Thr  Glu Arg Leu 
    2360                 2365                 2370             


Ala Arg  Ile Arg Gln Gly Gly  Ser Val Ala Gln Ala  Pro Ala Gly 
    2375                 2380                 2385             


Thr Ser  Phe Val Ala Pro Val  Gly His Ser Gly Ile  Trp Ser Phe 
    2390                 2395                 2400             


Gly Val  Asn Ala Val Ser Glu  Gly Leu Ser Gly Trp  Ser Gln Ser 
    2405                 2410                 2415             


Val Met  Gly Asn His Pro Met  His Gln Gln Leu Ser  Asp Pro Ser 
    2420                 2425                 2430             


Thr Phe  Ser Gln His Gln Pro  Met Glu Arg Asp Asp  Ser Gly Met 
    2435                 2440                 2445             


Val Ala  Pro Ser Asn Ile Phe  His Gln Pro Met Ala  Ser Gly Phe 
    2450                 2455                 2460             


Val Asp  Phe Ser Lys Gly Leu  Pro Ile Ser Met Tyr  Gly Gly Thr 
    2465                 2470                 2475             


Ile Ile  Pro Ser His Pro Gln  Leu Ala Asp Val Pro  Gly Gly Pro 
    2480                 2485                 2490             


Leu Phe  Asn Gly Leu His Asn  Pro Asp Pro Ala Trp  Asn Pro Met 
    2495                 2500                 2505             


Ile Lys  Val Ile Gln Asn Ser  Thr Glu Cys Thr Asp  Ala Gln Gln 
    2510                 2515                 2520             


Ile Trp  Pro Gly Thr Trp Ala  Pro His Ile Gly Asn  Met His Leu 
    2525                 2530                 2535             


Lys Tyr  Val Asn 
    2540         


<210>  530
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKH__Homo_sapiens__NP_473368

<400>  530

Met Val Lys Phe Pro Ala Leu Thr His Tyr Trp Pro Leu Ile Arg Phe 
1               5                   10                  15      


Leu Val Pro Leu Gly Ile Thr Asn Ile Ala Ile Asp Phe Gly Glu Gln 
            20                  25                  30          


Ala Leu Asn Arg Gly Ile Ala Ala Val Lys Glu Asp Ala Val Glu Met 
        35                  40                  45              


Leu Ala Ser Tyr Gly Leu Ala Tyr Ser Leu Met Lys Phe Phe Thr Gly 
    50                  55                  60                  


Pro Met Ser Asp Phe Lys Asn Val Gly Leu Val Phe Val Asn Ser Lys 
65                  70                  75                  80  


Arg Asp Arg Thr Lys Ala Val Leu Cys Met Val Val Ala Gly Ala Ile 
                85                  90                  95      


Ala Ala Val Phe His Thr Leu Ile Ala Tyr Ser Asp Leu Gly Tyr Tyr 
            100                 105                 110         


Ile Ile Asn Lys Leu His His Val Asp Glu Ser Val Gly Ser Lys Thr 
        115                 120                 125             


Arg Arg Ala Phe Leu Tyr Leu Ala Ala Phe Pro Phe Met Asp Ala Met 
    130                 135                 140                 


Ala Trp Thr His Ala Gly Ile Leu Leu Lys His Lys Tyr Ser Phe Leu 
145                 150                 155                 160 


Val Gly Cys Ala Ser Ile Ser Asp Val Ile Ala Gln Val Val Phe Val 
                165                 170                 175     


Ala Ile Leu Leu His Ser His Leu Glu Cys Arg Glu Pro Leu Leu Ile 
            180                 185                 190         


Pro Ile Leu Ser Leu Tyr Met Gly Ala Leu Val Arg Cys Thr Thr Leu 
        195                 200                 205             


Cys Leu Gly Tyr Tyr Lys Asn Ile His Asp Ile Ile Pro Asp Arg Ser 
    210                 215                 220                 


Gly Pro Glu Leu Gly Gly Asp Ala Thr Ile Arg Lys Met Leu Ser Phe 
225                 230                 235                 240 


Trp Trp Pro Leu Ala Leu Ile Leu Ala Thr Gln Arg Ile Ser Arg Pro 
                245                 250                 255     


Ile Val Asn Leu Phe Val Ser Arg Asp Leu Gly Gly Ser Ser Ala Ala 
            260                 265                 270         


Thr Glu Ala Val Ala Ile Leu Thr Ala Thr Tyr Pro Val Gly His Met 
        275                 280                 285             


Pro Tyr Gly Trp Leu Thr Glu Ile Arg Ala Val Tyr Pro Ala Phe Asp 
    290                 295                 300                 


Lys Asn Asn Pro Ser Asn Lys Leu Val Ser Thr Ser Asn Thr Val Thr 
305                 310                 315                 320 


Ala Ala His Ile Lys Lys Phe Thr Phe Val Cys Met Ala Leu Ser Leu 
                325                 330                 335     


Thr Leu Cys Phe Val Met Phe Trp Thr Pro Asn Val Ser Glu Lys Ile 
            340                 345                 350         


Leu Ile Asp Ile Ile Gly Val Asp Phe Ala Phe Ala Glu Leu Cys Val 
        355                 360                 365             


Val Pro Leu Arg Ile Phe Ser Phe Phe Pro Val Pro Val Thr Val Arg 
    370                 375                 380                 


Ala His Leu Thr Gly Trp Leu Met Thr Leu Lys Lys Thr Phe Val Leu 
385                 390                 395                 400 


Ala Pro Ser Ser Val Leu Arg Ile Ile Val Leu Ile Ala Ser Leu Val 
                405                 410                 415     


Val Leu Pro Tyr Leu Gly Val His Gly Ala Thr Leu Gly Val Gly Ser 
            420                 425                 430         


Leu Leu Ala Gly Phe Val Gly Glu Ser Thr Met Val Ala Ile Ala Ala 
        435                 440                 445             


Cys Tyr Val Tyr Arg Lys Gln Lys Lys Lys Met Glu Asn Glu Ser Ala 
    450                 455                 460                 


Thr Glu Gly Glu Asp Ser Ala Met Thr Asp Met Pro Pro Thr Glu Glu 
465                 470                 475                 480 


Val Thr Asp Ile Val Glu Met Arg Glu Glu Asn Glu 
                485                 490         


<210>  531
<211>  765
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKK1__Homo_sapiens__NP_848605

<400>  531

Met Ala Ala Asp Pro Thr Glu Leu Arg Leu Gly Ser Leu Pro Val Phe 
1               5                   10                  15      


Thr Arg Asp Asp Phe Glu Gly Asp Trp Arg Leu Val Ala Ser Gly Gly 
            20                  25                  30          


Phe Ser Gln Val Phe Gln Ala Arg His Arg Arg Trp Arg Thr Glu Tyr 
        35                  40                  45              


Ala Ile Lys Cys Ala Pro Cys Leu Pro Pro Asp Ala Ala Ser Ser Asp 
    50                  55                  60                  


Val Asn Tyr Leu Ile Glu Glu Ala Ala Lys Met Lys Lys Ile Lys Phe 
65                  70                  75                  80  


Gln His Ile Val Ser Ile Tyr Gly Val Cys Lys Gln Pro Leu Gly Ile 
                85                  90                  95      


Val Met Glu Phe Met Ala Asn Gly Ser Leu Glu Lys Val Leu Ser Thr 
            100                 105                 110         


His Ser Leu Cys Trp Lys Leu Arg Phe Arg Ile Ile His Glu Thr Ser 
        115                 120                 125             


Leu Ala Met Asn Phe Leu His Ser Ile Lys Pro Pro Leu Leu His Leu 
    130                 135                 140                 


Asp Leu Lys Pro Gly Asn Ile Leu Leu Asp Ser Asn Met His Val Lys 
145                 150                 155                 160 


Ile Ser Asp Phe Gly Leu Ser Lys Trp Met Glu Gln Ser Thr Arg Met 
                165                 170                 175     


Gln Tyr Ile Glu Arg Ser Ala Leu Arg Gly Met Leu Ser Tyr Ile Pro 
            180                 185                 190         


Pro Glu Met Phe Leu Glu Ser Asn Lys Ala Pro Gly Pro Lys Tyr Asp 
        195                 200                 205             


Val Tyr Ser Phe Ala Ile Val Ile Trp Glu Leu Leu Thr Gln Lys Lys 
    210                 215                 220                 


Pro Tyr Ser Gly Phe Asn Met Met Met Ile Ile Ile Arg Val Ala Ala 
225                 230                 235                 240 


Gly Met Arg Pro Ser Leu Gln Pro Val Ser Asp Gln Trp Pro Ser Glu 
                245                 250                 255     


Ala Gln Gln Met Val Asp Leu Met Lys Arg Cys Trp Asp Gln Asp Pro 
            260                 265                 270         


Lys Lys Arg Pro Cys Phe Leu Asp Ile Thr Ile Glu Thr Asp Ile Leu 
        275                 280                 285             


Leu Ser Leu Leu Gln Ser Arg Val Ala Val Pro Glu Ser Lys Ala Leu 
    290                 295                 300                 


Ala Arg Lys Val Ser Cys Lys Leu Ser Leu Arg Gln Pro Gly Glu Val 
305                 310                 315                 320 


Asn Glu Asp Ile Ser Gln Glu Leu Met Asp Ser Asp Ser Gly Asn Tyr 
                325                 330                 335     


Leu Lys Arg Ala Leu Gln Leu Ser Asp Arg Lys Asn Leu Val Pro Arg 
            340                 345                 350         


Asp Glu Glu Leu Cys Ile Tyr Glu Asn Lys Val Thr Pro Leu His Phe 
        355                 360                 365             


Leu Val Ala Gln Gly Ser Val Glu Gln Val Arg Leu Leu Leu Ala His 
    370                 375                 380                 


Glu Val Asp Val Asp Cys Gln Thr Ala Ser Gly Tyr Thr Pro Leu Leu 
385                 390                 395                 400 


Ile Ala Ala Gln Asp Gln Gln Pro Asp Leu Cys Ala Leu Leu Leu Ala 
                405                 410                 415     


His Gly Ala Asp Ala Asn Arg Val Asp Glu Asp Gly Trp Ala Pro Leu 
            420                 425                 430         


His Phe Ala Ala Gln Asn Gly Asp Asp Gly Thr Ala Arg Leu Leu Leu 
        435                 440                 445             


Asp His Gly Ala Cys Val Asp Ala Gln Glu Arg Glu Gly Trp Thr Pro 
    450                 455                 460                 


Leu His Leu Ala Ala Gln Asn Asn Phe Glu Asn Val Ala Arg Leu Leu 
465                 470                 475                 480 


Val Ser Arg Gln Ala Asp Pro Asn Leu His Glu Ala Glu Gly Lys Thr 
                485                 490                 495     


Pro Leu His Val Ala Ala Tyr Phe Gly His Val Ser Leu Val Lys Leu 
            500                 505                 510         


Leu Thr Ser Gln Gly Ala Glu Leu Asp Ala Gln Gln Arg Asn Leu Arg 
        515                 520                 525             


Thr Pro Leu His Leu Ala Val Glu Arg Gly Lys Val Arg Ala Ile Gln 
    530                 535                 540                 


His Leu Leu Lys Ser Gly Ala Val Pro Asp Ala Leu Asp Gln Ser Gly 
545                 550                 555                 560 


Tyr Gly Pro Leu His Thr Ala Ala Ala Arg Gly Lys Tyr Leu Ile Cys 
                565                 570                 575     


Lys Met Leu Leu Arg Tyr Gly Ala Ser Leu Glu Leu Pro Thr His Gln 
            580                 585                 590         


Gly Trp Thr Pro Leu His Leu Ala Ala Tyr Lys Gly His Leu Glu Ile 
        595                 600                 605             


Ile His Leu Leu Ala Glu Ser His Ala Asn Met Gly Ala Leu Gly Ala 
    610                 615                 620                 


Val Asn Trp Thr Pro Leu His Leu Ala Ala Arg His Gly Glu Glu Ala 
625                 630                 635                 640 


Val Val Ser Ala Leu Leu Gln Cys Gly Ala Asp Pro Asn Ala Ala Glu 
                645                 650                 655     


Gln Ser Gly Trp Thr Pro Leu His Leu Ala Val Gln Arg Ser Thr Phe 
            660                 665                 670         


Leu Ser Val Ile Asn Leu Leu Glu His His Ala Asn Val His Ala Arg 
        675                 680                 685             


Asn Lys Val Gly Trp Thr Pro Ala His Leu Ala Ala Leu Lys Gly Asn 
    690                 695                 700                 


Thr Ala Ile Leu Lys Val Leu Val Glu Ala Gly Ala Gln Leu Asp Val 
705                 710                 715                 720 


Gln Asp Gly Val Ser Cys Thr Pro Leu Gln Leu Ala Leu Arg Ser Arg 
                725                 730                 735     


Lys Gln Gly Ile Met Ser Phe Leu Glu Gly Lys Glu Pro Ser Val Ala 
            740                 745                 750         


Thr Leu Gly Gly Ser Lys Pro Gly Ala Glu Met Glu Ile 
        755                 760                 765 


<210>  532
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKLE1__Homo_sapiens__NP_001265373

<400>  532

Met Trp Thr Pro Val Arg Arg Gly Ala Ala Trp Leu Gly Thr Leu Leu 
1               5                   10                  15      


Gly Pro Gly Glu Gly Pro Pro Glu Pro Arg Gly Gly Ala Ala His Ala 
            20                  25                  30          


His Lys Pro Pro Ala Gly Ser Arg Lys Ser Thr Asp Gln Ala Val Arg 
        35                  40                  45              


Phe Gly Pro Ser Gln Gly Met Cys Ser Glu Ala Arg Leu Ala Arg Arg 
    50                  55                  60                  


Leu Arg Asp Ala Leu Arg Glu Glu Glu Pro Trp Ala Val Glu Glu Leu 
65                  70                  75                  80  


Leu Arg Cys Gly Ala Asp Pro Asn Leu Val Leu Glu Asp Gly Ala Ala 
                85                  90                  95      


Ala Val His Leu Ala Ala Gly Ala Arg His Pro Arg Gly Leu Arg Cys 
            100                 105                 110         


Leu Gly Ala Leu Leu Arg Gln Gly Gly Asp Pro Asn Ala Arg Ser Val 
        115                 120                 125             


Glu Ala Leu Thr Pro Leu His Val Ala Ala Ala Trp Gly Cys Arg Arg 
    130                 135                 140                 


Gly Leu Glu Leu Leu Leu Ser Gln Gly Ala Asp Pro Ala Leu Arg Asp 
145                 150                 155                 160 


Gln Asp Gly Leu Arg Pro Leu Asp Leu Ala Leu Gln Gln Gly His Leu 
                165                 170                 175     


Glu Cys Ala Arg Val Leu Gln Asp Leu Asp Thr Arg Thr Arg Thr Arg 
            180                 185                 190         


Thr Arg Ile Gly Ala Glu Thr Gln Glu Pro Glu Pro Ala Pro Gly Thr 
        195                 200                 205             


Pro Gly Leu Ser Gly Pro Thr Asp Glu Thr Leu Asp Ser Ile Ala Leu 
    210                 215                 220                 


Gln Lys Gln Pro Cys Arg Gly Asp Asn Arg Asp Ile Gly Leu Glu Ala 
225                 230                 235                 240 


Asp Pro Gly Pro Pro Ser Leu Pro Val Pro Leu Glu Thr Val Asp Lys 
                245                 250                 255     


His Gly Ser Ser Ala Ser Pro Pro Gly His Trp Asp Tyr Ser Ser Asp 
            260                 265                 270         


Ala Ser Phe Val Thr Ala Val Glu Val Ser Gly Ala Glu Asp Pro Ala 
        275                 280                 285             


Ser Asp Thr Pro Pro Trp Ala Gly Ser Leu Pro Pro Thr Arg Gln Gly 
    290                 295                 300                 


Leu Leu His Val Val His Ala Asn Gln Arg Val Pro Arg Ser Gln Gly 
305                 310                 315                 320 


Thr Glu Ala Glu Leu Asn Ala Arg Leu Gln Ala Leu Thr Leu Thr Pro 
                325                 330                 335     


Pro Asn Ala Ala Gly Phe Gln Ser Ser Pro Ser Ser Met Pro Leu Leu 
            340                 345                 350         


Asp Arg Ser Pro Ala His Ser Pro Pro Arg Thr Pro Thr Pro Gly Ala 
        355                 360                 365             


Ser Asp Cys His Cys Leu Trp Glu His Gln Thr Ser Ile Asp Ser Asp 
    370                 375                 380                 


Met Ala Thr Leu Trp Leu Thr Glu Asp Glu Ala Ser Ser Thr Gly Gly 
385                 390                 395                 400 


Arg Glu Pro Val Gly Pro Cys Arg His Leu Pro Val Ser Thr Val Ser 
                405                 410                 415     


Asp Leu Glu Leu Leu Lys Gly Leu Arg Ala Leu Gly Pro Glu Phe Ser 
            420                 425                 430         


Gly His Ser Leu Glu Leu Ala Ala Ala Leu Arg Thr Gly Cys Ile Pro 
        435                 440                 445             


Asp Val Gln Ala Asp Glu Asp Ala Leu Ala Gln Gln Phe Glu Gln Pro 
    450                 455                 460                 


Asp Pro Ala Arg Arg Trp Arg Glu Gly Val Val Lys Ser Ser Phe Thr 
465                 470                 475                 480 


Tyr Leu Leu Leu Asp Pro Arg Glu Thr Gln Asp Leu Pro Ala Arg Ala 
                485                 490                 495     


Phe Ser Leu Thr Pro Ala Glu Arg Leu Gln Thr Phe Ile Arg Ala Ile 
            500                 505                 510         


Phe Tyr Val Gly Lys Gly Thr Arg Ala Arg Pro Tyr Val His Leu Trp 
        515                 520                 525             


Glu Ala Leu Gly His His Gly Arg Ser Arg Lys Gln Gly Ser Arg Arg 
    530                 535                 540                 


Ser Pro Thr Arg Ser Lys Gly Thr Ala Met Glu Trp Trp Gln Ala Gly 
545                 550                 555                 560 


His Leu Leu Val Ala Gly Ala Trp Gly Cys Thr Cys Cys Thr Val Pro 
                565                 570                 575     


Ser Leu Ser Ser Trp Leu Lys Ala Ser Asp Ser Phe Ile Pro Arg Thr 
            580                 585                 590         


Ser Arg Pro Gly Ala Glu Cys Trp Gly Val Gly His Pro Ala Trp Gly 
        595                 600                 605             


Glu Met Phe Glu Cys Ser Ser Cys Pro Met Leu Thr Ala Ala Pro Ile 
    610                 615                 620                 


Ser Gly Phe Arg Arg Gly Val Cys Val Cys Val Cys Val Cys Val Cys 
625                 630                 635                 640 


Val Cys Val Cys Leu Cys Val Cys Val Cys Val 
                645                 650     


<210>  533
<211>  938
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKLE2__Homo_sapiens__NP_055929

<400>  533

Met Leu Trp Pro Arg Leu Ala Ala Ala Glu Trp Ala Ala Leu Ala Trp 
1               5                   10                  15      


Glu Leu Leu Gly Ala Ser Val Leu Leu Ile Ala Val Arg Trp Leu Val 
            20                  25                  30          


Arg Arg Leu Gly Pro Arg Pro Gly Gly Leu Gly Arg Ser Gly Thr Pro 
        35                  40                  45              


Val Pro Pro Pro Ser Ala Ala Ala Ala Pro Ala Ser Gly Glu Met Thr 
    50                  55                  60                  


Met Asp Ala Leu Leu Ala Arg Leu Lys Leu Leu Asn Pro Asp Asp Leu 
65                  70                  75                  80  


Arg Glu Glu Ile Val Lys Ala Gly Leu Lys Cys Gly Pro Ile Thr Ser 
                85                  90                  95      


Thr Thr Arg Phe Ile Phe Glu Lys Lys Leu Ala Gln Ala Leu Leu Glu 
            100                 105                 110         


Gln Gly Gly Arg Leu Ser Ser Phe Tyr His His Glu Ala Gly Val Thr 
        115                 120                 125             


Ala Leu Ser Gln Asp Pro Gln Arg Ile Leu Lys Pro Ala Glu Gly Asn 
    130                 135                 140                 


Pro Thr Asp Gln Ala Gly Phe Ser Glu Asp Arg Asp Phe Gly Tyr Ser 
145                 150                 155                 160 


Val Gly Leu Asn Pro Pro Glu Glu Glu Ala Val Thr Ser Lys Thr Cys 
                165                 170                 175     


Ser Val Pro Pro Ser Asp Thr Asp Thr Tyr Arg Ala Gly Ala Thr Ala 
            180                 185                 190         


Ser Lys Glu Pro Pro Leu Tyr Tyr Gly Val Cys Pro Val Tyr Glu Asp 
        195                 200                 205             


Val Pro Ala Arg Asn Glu Arg Ile Tyr Val Tyr Glu Asn Lys Lys Glu 
    210                 215                 220                 


Ala Leu Gln Ala Val Lys Met Ile Lys Gly Ser Arg Phe Lys Ala Phe 
225                 230                 235                 240 


Ser Thr Arg Glu Asp Ala Glu Lys Phe Ala Arg Gly Ile Cys Asp Tyr 
                245                 250                 255     


Phe Pro Ser Pro Ser Lys Thr Ser Leu Pro Leu Ser Pro Val Lys Thr 
            260                 265                 270         


Ala Pro Leu Phe Ser Asn Asp Arg Leu Lys Asp Gly Leu Cys Leu Ser 
        275                 280                 285             


Glu Ser Glu Thr Val Asn Lys Glu Arg Ala Asn Ser Tyr Lys Asn Pro 
    290                 295                 300                 


Arg Thr Gln Asp Leu Thr Ala Lys Leu Arg Lys Ala Val Glu Lys Gly 
305                 310                 315                 320 


Glu Glu Asp Thr Phe Ser Asp Leu Ile Trp Ser Asn Pro Arg Tyr Leu 
                325                 330                 335     


Ile Gly Ser Gly Asp Asn Pro Thr Ile Val Gln Glu Gly Cys Arg Tyr 
            340                 345                 350         


Asn Val Met His Val Ala Ala Lys Glu Asn Gln Ala Ser Ile Cys Gln 
        355                 360                 365             


Leu Thr Leu Asp Val Leu Glu Asn Pro Asp Phe Met Arg Leu Met Tyr 
    370                 375                 380                 


Pro Asp Asp Asp Glu Ala Met Leu Gln Lys Arg Ile Arg Tyr Val Val 
385                 390                 395                 400 


Asp Leu Tyr Leu Asn Thr Pro Asp Lys Met Gly Tyr Asp Thr Pro Leu 
                405                 410                 415     


His Phe Ala Cys Lys Phe Gly Asn Ala Asp Val Val Asn Val Leu Ser 
            420                 425                 430         


Ser His His Leu Ile Val Lys Asn Ser Arg Asn Lys Tyr Asp Lys Thr 
        435                 440                 445             


Pro Glu Asp Val Ile Cys Glu Arg Ser Lys Asn Lys Ser Val Glu Leu 
    450                 455                 460                 


Lys Glu Arg Ile Arg Glu Tyr Leu Lys Gly His Tyr Tyr Val Pro Leu 
465                 470                 475                 480 


Leu Arg Ala Glu Glu Thr Ser Ser Pro Val Ile Gly Glu Leu Trp Ser 
                485                 490                 495     


Pro Asp Gln Thr Ala Glu Ala Ser His Val Ser Arg Tyr Gly Gly Ser 
            500                 505                 510         


Pro Arg Asp Pro Val Leu Thr Leu Arg Ala Phe Ala Gly Pro Leu Ser 
        515                 520                 525             


Pro Ala Lys Ala Glu Asp Phe Arg Lys Leu Trp Lys Thr Pro Pro Arg 
    530                 535                 540                 


Glu Lys Ala Gly Phe Leu His His Val Lys Lys Ser Asp Pro Glu Arg 
545                 550                 555                 560 


Gly Phe Glu Arg Val Gly Arg Glu Leu Ala His Glu Leu Gly Tyr Pro 
                565                 570                 575     


Trp Val Glu Tyr Trp Glu Phe Leu Gly Cys Phe Val Asp Leu Ser Ser 
            580                 585                 590         


Gln Glu Gly Leu Gln Arg Leu Glu Glu Tyr Leu Thr Gln Gln Glu Ile 
        595                 600                 605             


Gly Lys Lys Ala Gln Gln Glu Thr Gly Glu Arg Glu Ala Ser Cys Arg 
    610                 615                 620                 


Asp Lys Ala Thr Thr Ser Gly Ser Asn Ser Ile Ser Val Arg Ala Phe 
625                 630                 635                 640 


Leu Asp Glu Asp Asp Met Ser Leu Glu Glu Ile Lys Asn Arg Gln Asn 
                645                 650                 655     


Ala Ala Arg Asn Asn Ser Pro Pro Thr Val Gly Ala Phe Gly His Thr 
            660                 665                 670         


Arg Cys Ser Ala Phe Pro Leu Glu Gln Glu Ala Asp Leu Ile Glu Ala 
        675                 680                 685             


Ala Glu Pro Gly Gly Pro His Ser Ser Arg Asn Gly Leu Cys His Pro 
    690                 695                 700                 


Leu Asn His Ser Arg Thr Leu Ala Gly Lys Arg Pro Lys Ala Pro Arg 
705                 710                 715                 720 


Gly Glu Glu Ala His Leu Pro Pro Val Ser Asp Leu Thr Val Glu Phe 
                725                 730                 735     


Asp Lys Leu Asn Leu Gln Asn Ile Gly Arg Ser Val Ser Lys Thr Pro 
            740                 745                 750         


Asp Glu Ser Thr Lys Thr Lys Asp Gln Ile Leu Thr Ser Arg Ile Asn 
        755                 760                 765             


Ala Val Glu Arg Asp Leu Leu Glu Pro Ser Pro Ala Asp Gln Leu Gly 
    770                 775                 780                 


Asn Gly His Arg Arg Thr Glu Ser Glu Met Ser Ala Arg Ile Ala Lys 
785                 790                 795                 800 


Met Ser Leu Ser Pro Ser Ser Pro Arg His Glu Asp Gln Leu Glu Val 
                805                 810                 815     


Thr Arg Glu Pro Ala Arg Arg Leu Phe Leu Phe Gly Glu Glu Pro Ser 
            820                 825                 830         


Lys Leu Asp Gln Asp Val Leu Ala Ala Leu Glu Cys Ala Asp Val Asp 
        835                 840                 845             


Pro His Gln Phe Pro Ala Val His Arg Trp Lys Ser Ala Val Leu Cys 
    850                 855                 860                 


Tyr Ser Pro Ser Asp Arg Gln Ser Trp Pro Ser Pro Ala Val Lys Gly 
865                 870                 875                 880 


Arg Phe Lys Ser Gln Leu Pro Asp Leu Ser Gly Pro His Ser Tyr Ser 
                885                 890                 895     


Pro Gly Arg Asn Ser Val Ala Gly Ser Asn Pro Ala Lys Pro Gly Leu 
            900                 905                 910         


Gly Ser Pro Gly Arg Tyr Ser Pro Val His Gly Ser Gln Leu Arg Arg 
        915                 920                 925             


Met Ala Arg Leu Ala Glu Leu Ala Ala Leu 
    930                 935             


<210>  534
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKMY1__Homo_sapiens__NP_001269700

<400>  534

Met Glu Gly Ala His Ala Ser Leu Ser Leu Glu Asp Glu Val Ser Gly 
1               5                   10                  15      


Ala Gly Ser Arg Gln Arg Pro Leu Glu Gly Lys Gly Gly Glu Thr Pro 
            20                  25                  30          


Ala Ala Glu Glu Pro Gly Ser Leu Lys Asn Tyr Ala Val Phe Ala Thr 
        35                  40                  45              


Arg Asp Val Ser Ala Ala Pro Glu Lys Glu Glu Glu Glu Ala Glu Gly 
    50                  55                  60                  


Pro Leu Arg Ala Gln Asp Leu Arg Glu Ser Tyr Ile Gln Leu Val Gln 
65                  70                  75                  80  


Gly Val Gln Glu Trp Gln Asp Gly Cys Met Tyr Gln Gly Glu Phe Gly 
                85                  90                  95      


Leu Asn Met Lys Leu Gly Tyr Gly Lys Phe Ser Trp Pro Thr Gly Glu 
            100                 105                 110         


Ser Tyr His Gly Gln Phe Tyr Arg Asp His Cys His Gly Leu Gly Thr 
        115                 120                 125             


Tyr Met Trp Pro Asp Gly Ser Ser Phe Thr Gly Thr Phe Tyr Leu Ser 
    130                 135                 140                 


His Arg Glu Gly Tyr Gly Thr Met Tyr Met Lys Thr Arg Leu Phe Gln 
145                 150                 155                 160 


Gly Leu Tyr Lys Ala Asp Gln Arg Phe Gly Pro Gly Val Glu Thr Tyr 
                165                 170                 175     


Pro Asp Gly Ser Gln Asp Val Gly Leu Trp Phe Arg Glu Gln Leu Ile 
            180                 185                 190         


Lys Leu Cys Thr Gln Ile Pro Ser Gly Phe Ser Leu Leu Arg Tyr Pro 
        195                 200                 205             


Glu Phe Ser Ser Phe Ile Thr His Ser Pro Ala Arg Ile Ser Leu Ser 
    210                 215                 220                 


Glu Glu Glu Lys Thr Glu Trp Gly Leu Gln Glu Gly Gln Asp Pro Phe 
225                 230                 235                 240 


Phe Tyr Asp Tyr Lys Arg Phe Leu Leu Asn Asp Asn Leu Thr Leu Pro 
                245                 250                 255     


Pro Glu Met Tyr Val Tyr Ser Thr Asn Ser Asp His Leu Pro Met Thr 
            260                 265                 270         


Ser Ser Phe Arg Lys Glu Leu Asp Ala Arg Ile Phe Leu Asn Glu Ile 
        275                 280                 285             


Pro Pro Phe Val Glu Asp Gly Glu Pro Trp Phe Ile Ile Asn Glu Thr 
    290                 295                 300                 


Pro Leu Leu Val Lys Ile Gln Lys Gln Thr Tyr Lys Phe Arg Asn Lys 
305                 310                 315                 320 


Pro Ala His Thr Ser Trp Asn Met Gly Ala Ile Leu Glu Gly Lys Arg 
                325                 330                 335     


Ser Gly Phe Ala Pro Cys Gly Pro Lys Glu Gln Leu Ser Met Glu Met 
            340                 345                 350         


Ile Leu Lys Ala Glu Glu Gly Asn His Glu Trp Ile Cys Arg Ile Leu 
        355                 360                 365             


Lys Asp Asn Phe Ala Ser Ala Asp Val Ala Asp Ala Lys Gly Tyr Thr 
    370                 375                 380                 


Val Leu Ala Ala Ala Ala Thr His Cys His Asn Asp Ile Val Asn Leu 
385                 390                 395                 400 


Leu Leu Asp Cys Gly Ala Asp Val Asn Lys Cys Ser Asp Glu Gly Leu 
                405                 410                 415     


Thr Ala Leu Ser Met Cys Phe Leu Leu His Tyr Pro Ala Gln Ser Phe 
            420                 425                 430         


Lys Pro Asn Val Ala Glu Arg Thr Ile Pro Glu Pro Gln Glu Pro Pro 
        435                 440                 445             


Lys Phe Pro Val Val Pro Ile Leu Ser Ser Ser Phe Met Asp Thr Asn 
    450                 455                 460                 


Leu Glu Ser Leu Tyr Tyr Glu Val Asn Val Pro Ser Gln Gly Ser Tyr 
465                 470                 475                 480 


Glu Leu Arg Pro Pro Pro Ala Pro Leu Leu Leu Pro Arg Val Ser Gly 
                485                 490                 495     


Ser His Glu Gly Gly His Phe Gln Asp Thr Gly Gln Cys Gly Gly Ser 
            500                 505                 510         


Ile Asp His Arg Ser Ser Ser Leu Lys Gly Asp Ser Pro Leu Val Lys 
        515                 520                 525             


Gly Ser Leu Gly His Val Glu Ser Gly Leu Glu Asp Val Leu Gly Asn 
    530                 535                 540                 


Thr Asp Arg Gly Ser Leu Cys Ser Ala Glu Thr Lys Phe Glu Ser Asn 
545                 550                 555                 560 


Val Cys Val Cys Asp Phe Ser Ile Glu Leu Ser Gln Ala Met Leu Glu 
                565                 570                 575     


Arg Ser Ala Gln Ser His Ser Leu Leu Lys Met Ala Ser Pro Ser Pro 
            580                 585                 590         


Cys Thr Ser Ser Phe Asp Lys Gly Thr Met Arg Arg Met Ala Leu Ser 
        595                 600                 605             


Met Ile Glu Arg Arg Lys Arg Trp Arg Thr Ile Lys Leu Leu Leu Arg 
    610                 615                 620                 


Arg Gly Ala Asp Pro Asn Leu Cys Cys Val Pro Met Gln Val Leu Phe 
625                 630                 635                 640 


Leu Ala Val Lys Ala Gly Asp Val Asp Gly Val Arg Leu Leu Leu Glu 
                645                 650                 655     


His Gly Ala Arg Thr Asp Ile Cys Phe Pro Pro Gln Leu Ser Thr Leu 
            660                 665                 670         


Thr Pro Leu His Ile Ala Ala Ala Leu Pro Gly Glu Glu Gly Val Gln 
        675                 680                 685             


Ile Val Glu Leu Leu Leu His Ala Ile Thr Asp Val Asp Ala Lys Ala 
    690                 695                 700                 


Ser Asp Glu Asp Asp Thr Tyr Lys Pro Gly Lys Leu Asp Leu Leu Pro 
705                 710                 715                 720 


Ser Ser Leu Lys Leu Ser Asn Glu Pro Gly Pro Pro Gln Ala Tyr Tyr 
                725                 730                 735     


Ser Thr Asp Thr Ala Leu Pro Glu Glu Gly Gly Arg Thr Ala Leu His 
            740                 745                 750         


Met Ala Cys Glu Arg Glu Asp Asp Asn Lys Cys Ala Arg Asp Ile Val 
        755                 760                 765             


Arg Leu Leu Leu Ser His Gly Ala Asn Pro Asn Leu Leu Trp Ser Gly 
    770                 775                 780                 


His Ser Pro Leu Ser Leu Ser Ile Ala Ser Gly Asn Glu Leu Val Val 
785                 790                 795                 800 


Lys Glu Leu Leu Thr Gln Gly Ala Asp Pro Asn Leu Pro Leu Thr Lys 
                805                 810                 815     


Gly Leu Gly Ser Ala Leu Cys Val Ala Cys Asp Leu Thr Tyr Glu His 
            820                 825                 830         


Gln Arg Asn Met Asp Ser Lys Leu Ala Leu Ile Asp Arg Leu Ile Ser 
        835                 840                 845             


His Gly Ala Asp Ile Leu Lys Pro Val Met Leu Arg Gln Gly Glu Lys 
    850                 855                 860                 


Glu Ala Val Gly Thr Ala Val Asp Tyr Gly Tyr Phe Arg Phe Phe Gln 
865                 870                 875                 880 


Asp Arg Arg Ile Ala Arg Cys Pro Phe His Thr Leu Met Pro Ala Glu 
                885                 890                 895     


Arg Glu Thr Phe Leu Ala Arg Lys Arg Leu Leu Glu Tyr Met Gly Leu 
            900                 905                 910         


Gln Leu Arg Gln Ala Val Phe Ala Lys Glu Ser Gln Trp Asp Pro Thr 
        915                 920                 925             


Trp Leu Tyr Leu Cys Lys Arg Ala Glu Leu Ile Pro Ser His Arg Met 
    930                 935                 940                 


Lys Lys Lys Gly Pro Ser Leu Pro Arg Gly Leu Asp Val Lys Glu Gln 
945                 950                 955                 960 


Gly Gln Ile Pro Phe Phe Lys Phe Cys Tyr Gln Cys Gly Arg Ser Ile 
                965                 970                 975     


Gly Val Arg Leu Leu Pro Cys Pro Arg Cys Tyr Gly Ile Leu Thr Cys 
            980                 985                 990         


Ser Lys Tyr Cys Lys Thr Lys Ala  Trp Thr Glu Phe His  Lys Lys Asp 
        995                 1000                 1005             


Cys Gly  Asp Leu Val Ala Ile  Val Thr Gln Leu Glu  Gln Val Ser 
    1010                 1015                 1020             


Arg Arg  Arg Glu Glu Phe Gln  
    1025                 1030 


<210>  535
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD10__Homo_sapiens__NP_001273650

<400>  535

Met Ser Ala Ala Gly Ala Gly Ala Gly Val Glu Ala Gly Phe Ser Ser 
1               5                   10                  15      


Glu Glu Leu Leu Ser Leu Arg Phe Pro Leu His Arg Ala Cys Arg Asp 
            20                  25                  30          


Gly Asp Leu Ala Thr Leu Cys Ser Leu Leu Gln Gln Thr Pro His Ala 
        35                  40                  45              


His Leu Ala Ser Glu Asp Ser Phe Tyr Gly Trp Thr Pro Val His Trp 
    50                  55                  60                  


Ala Ala His Phe Gly Lys Leu Glu Cys Leu Val Gln Leu Val Arg Ala 
65                  70                  75                  80  


Gly Ala Thr Leu Asn Val Ser Thr Thr Arg Tyr Ala Gln Thr Pro Ala 
                85                  90                  95      


His Ile Ala Ala Phe Gly Gly His Pro Gln Cys Leu Val Trp Leu Ile 
            100                 105                 110         


Gln Ala Gly Ala Asn Ile Asn Lys Pro Asp Cys Glu Gly Glu Thr Pro 
        115                 120                 125             


Ile His Lys Ala Ala Arg Ser Gly Ser Leu Glu Cys Ile Ser Ala Leu 
    130                 135                 140                 


Val Ala Asn Gly Ala His Val Glu Phe Ile Ser Gln Ser Ser Val His 
145                 150                 155                 160 


Ser Cys Leu Pro Gly Glu Leu Gln His Gly Val Thr Phe Asp Pro Ser 
                165                 170                 175     


Val Leu Ile Gln Cys Leu Lys Pro Glu Lys Cys Gln Trp Pro Asp Ser 
            180                 185                 190         


Ser Arg His Cys Thr Asn Pro Gly Phe Pro Arg Val Cys Pro Val Ser 
        195                 200                 205             


Leu Glu Pro Pro Glu Leu Ser Ser Glu Pro Phe Leu 
    210                 215                 220 


<210>  536
<211>  2663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD11__Homo_sapiens__NP_037407

<400>  536

Met Pro Lys Gly Gly Cys Pro Lys Ala Pro Gln Gln Glu Glu Leu Pro 
1               5                   10                  15      


Leu Ser Ser Asp Met Val Glu Lys Gln Thr Gly Lys Lys Asp Lys Asp 
            20                  25                  30          


Lys Val Ser Leu Thr Lys Thr Pro Lys Leu Glu Arg Gly Asp Gly Gly 
        35                  40                  45              


Lys Glu Val Arg Glu Arg Ala Ser Lys Arg Lys Leu Pro Phe Thr Ala 
    50                  55                  60                  


Gly Ala Asn Gly Glu Gln Lys Asp Ser Asp Thr Glu Lys Gln Gly Pro 
65                  70                  75                  80  


Glu Arg Lys Arg Ile Lys Lys Glu Pro Val Thr Arg Lys Ala Gly Leu 
                85                  90                  95      


Leu Phe Gly Met Gly Leu Ser Gly Ile Arg Ala Gly Tyr Pro Leu Ser 
            100                 105                 110         


Glu Arg Gln Gln Val Ala Leu Leu Met Gln Met Thr Ala Glu Glu Ser 
        115                 120                 125             


Ala Asn Ser Pro Val Asp Thr Thr Pro Lys His Pro Ser Gln Ser Thr 
    130                 135                 140                 


Val Cys Gln Lys Gly Thr Pro Asn Ser Ala Ser Lys Thr Lys Asp Lys 
145                 150                 155                 160 


Val Asn Lys Arg Asn Glu Arg Gly Glu Thr Arg Leu His Arg Ala Ala 
                165                 170                 175     


Ile Arg Gly Asp Ala Arg Arg Ile Lys Glu Leu Ile Ser Glu Gly Ala 
            180                 185                 190         


Asp Val Asn Val Lys Asp Phe Ala Gly Trp Thr Ala Leu His Glu Ala 
        195                 200                 205             


Cys Asn Arg Gly Tyr Tyr Asp Val Ala Lys Gln Leu Leu Ala Ala Gly 
    210                 215                 220                 


Ala Glu Val Asn Thr Lys Gly Leu Asp Asp Asp Thr Pro Leu His Asp 
225                 230                 235                 240 


Ala Ala Asn Asn Gly His Tyr Lys Val Val Lys Leu Leu Leu Arg Tyr 
                245                 250                 255     


Gly Gly Asn Pro Gln Gln Ser Asn Arg Lys Gly Glu Thr Pro Leu Lys 
            260                 265                 270         


Val Ala Asn Ser Pro Thr Met Val Asn Leu Leu Leu Gly Lys Gly Thr 
        275                 280                 285             


Tyr Thr Ser Ser Glu Glu Ser Ser Thr Glu Ser Ser Glu Glu Glu Asp 
    290                 295                 300                 


Ala Pro Ser Phe Ala Pro Ser Ser Ser Val Asp Gly Asn Asn Thr Asp 
305                 310                 315                 320 


Ser Glu Phe Glu Lys Gly Leu Lys His Lys Ala Lys Asn Pro Glu Pro 
                325                 330                 335     


Gln Lys Ala Thr Ala Pro Val Lys Asp Glu Tyr Glu Phe Asp Glu Asp 
            340                 345                 350         


Asp Glu Gln Asp Arg Val Pro Pro Val Asp Asp Lys His Leu Leu Lys 
        355                 360                 365             


Lys Asp Tyr Arg Lys Glu Thr Lys Ser Asn Ser Phe Ile Ser Ile Pro 
    370                 375                 380                 


Lys Met Glu Val Lys Ser Tyr Thr Lys Asn Asn Thr Ile Ala Pro Lys 
385                 390                 395                 400 


Lys Ala Ser His Arg Ile Leu Ser Asp Thr Ser Asp Glu Glu Asp Ala 
                405                 410                 415     


Ser Val Thr Val Gly Thr Gly Glu Lys Leu Arg Leu Ser Ala His Thr 
            420                 425                 430         


Ile Leu Pro Gly Ser Lys Thr Arg Glu Pro Ser Asn Ala Lys Gln Gln 
        435                 440                 445             


Lys Glu Lys Asn Lys Val Lys Lys Lys Arg Lys Lys Glu Thr Lys Gly 
    450                 455                 460                 


Arg Glu Val Arg Phe Gly Lys Arg Ser Asp Lys Phe Cys Ser Ser Glu 
465                 470                 475                 480 


Ser Glu Ser Glu Ser Ser Glu Ser Gly Glu Asp Asp Arg Asp Ser Leu 
                485                 490                 495     


Gly Ser Ser Gly Cys Leu Lys Gly Ser Pro Leu Val Leu Lys Asp Pro 
            500                 505                 510         


Ser Leu Phe Ser Ser Leu Ser Ala Ser Ser Thr Ser Ser His Gly Ser 
        515                 520                 525             


Ser Ala Ala Gln Lys Gln Asn Pro Ser His Thr Asp Gln His Thr Lys 
    530                 535                 540                 


His Trp Arg Thr Asp Asn Trp Lys Thr Ile Ser Ser Pro Ala Trp Ser 
545                 550                 555                 560 


Glu Val Ser Ser Leu Ser Asp Ser Thr Arg Thr Arg Leu Thr Ser Glu 
                565                 570                 575     


Ser Asp Tyr Ser Ser Glu Gly Ser Ser Val Glu Ser Leu Lys Pro Val 
            580                 585                 590         


Arg Lys Arg Gln Glu His Arg Lys Arg Ala Ser Leu Ser Glu Lys Lys 
        595                 600                 605             


Ser Pro Phe Leu Ser Ser Ala Glu Gly Ala Val Pro Lys Leu Asp Lys 
    610                 615                 620                 


Glu Gly Lys Val Val Lys Lys His Lys Thr Lys His Lys His Lys Asn 
625                 630                 635                 640 


Lys Glu Lys Gly Gln Cys Ser Ile Ser Gln Glu Leu Lys Leu Lys Ser 
                645                 650                 655     


Phe Thr Tyr Glu Tyr Glu Asp Ser Lys Gln Lys Ser Asp Lys Ala Ile 
            660                 665                 670         


Leu Leu Glu Asn Asp Leu Ser Thr Glu Asn Lys Leu Lys Val Leu Lys 
        675                 680                 685             


His Asp Arg Asp His Phe Lys Lys Glu Glu Lys Leu Ser Lys Met Lys 
    690                 695                 700                 


Leu Glu Glu Lys Glu Trp Leu Phe Lys Asp Glu Lys Ser Leu Lys Arg 
705                 710                 715                 720 


Ile Lys Asp Thr Asn Lys Asp Ile Ser Arg Ser Phe Arg Glu Glu Lys 
                725                 730                 735     


Asp Arg Ser Asn Lys Ala Glu Lys Glu Arg Ser Leu Lys Glu Lys Ser 
            740                 745                 750         


Pro Lys Glu Glu Lys Leu Arg Leu Tyr Lys Glu Glu Arg Lys Lys Lys 
        755                 760                 765             


Ser Lys Asp Arg Pro Ser Lys Leu Glu Lys Lys Asn Asp Leu Lys Glu 
    770                 775                 780                 


Asp Lys Ile Ser Lys Glu Lys Glu Lys Ile Phe Lys Glu Asp Lys Glu 
785                 790                 795                 800 


Lys Leu Lys Lys Glu Lys Val Tyr Arg Glu Asp Ser Ala Phe Asp Glu 
                805                 810                 815     


Tyr Cys Asn Lys Asn Gln Phe Leu Glu Asn Glu Asp Thr Lys Phe Ser 
            820                 825                 830         


Leu Ser Asp Asp Gln Arg Asp Arg Trp Phe Ser Asp Leu Ser Asp Ser 
        835                 840                 845             


Ser Phe Asp Phe Lys Gly Glu Asp Ser Trp Asp Ser Pro Val Thr Asp 
    850                 855                 860                 


Tyr Arg Asp Met Lys Ser Asp Ser Val Ala Lys Leu Ile Leu Glu Thr 
865                 870                 875                 880 


Val Lys Glu Asp Ser Lys Glu Arg Arg Arg Asp Ser Arg Ala Arg Glu 
                885                 890                 895     


Lys Arg Asp Tyr Arg Glu Pro Phe Phe Arg Lys Lys Asp Arg Asp Tyr 
            900                 905                 910         


Leu Asp Lys Asn Ser Glu Lys Arg Lys Glu Gln Thr Glu Lys His Lys 
        915                 920                 925             


Ser Val Pro Gly Tyr Leu Ser Glu Lys Asp Lys Lys Arg Arg Glu Ser 
    930                 935                 940                 


Ala Glu Ala Gly Arg Asp Arg Lys Asp Ala Leu Glu Ser Cys Lys Glu 
945                 950                 955                 960 


Arg Arg Asp Gly Arg Ala Lys Pro Glu Glu Ala His Arg Glu Glu Leu 
                965                 970                 975     


Lys Glu Cys Gly Cys Glu Ser Gly Phe Lys Asp Lys Ser Asp Gly Asp 
            980                 985                 990         


Phe Gly Lys Gly Leu Glu Pro Trp  Glu Arg His His Pro  Ala Arg Glu 
        995                 1000                 1005             


Lys Glu  Lys Lys Asp Gly Pro  Asp Lys Glu Arg Lys  Glu Lys Thr 
    1010                 1015                 1020             


Lys Pro  Glu Arg Tyr Lys Glu  Lys Ser Ser Asp Lys  Asp Lys Ser 
    1025                 1030                 1035             


Glu Lys  Ser Ile Leu Glu Lys  Cys Gln Lys Asp Lys  Glu Phe Asp 
    1040                 1045                 1050             


Lys Cys  Phe Lys Glu Lys Lys  Asp Thr Lys Glu Lys  His Lys Asp 
    1055                 1060                 1065             


Thr His  Gly Lys Asp Lys Glu  Arg Lys Ala Ser Leu  Asp Gln Gly 
    1070                 1075                 1080             


Lys Glu  Lys Lys Glu Lys Ala  Phe Pro Gly Ile Ile  Ser Glu Asp 
    1085                 1090                 1095             


Phe Ser  Glu Lys Lys Asp Asp  Lys Lys Gly Lys Glu  Lys Ser Trp 
    1100                 1105                 1110             


Tyr Ile  Ala Asp Ile Phe Thr  Asp Glu Ser Glu Asp  Asp Arg Asp 
    1115                 1120                 1125             


Ser Cys  Met Gly Ser Gly Phe  Lys Met Gly Glu Ala  Ser Asp Leu 
    1130                 1135                 1140             


Pro Arg  Thr Asp Gly Leu Gln  Glu Lys Glu Glu Gly  Arg Glu Ala 
    1145                 1150                 1155             


Tyr Ala  Ser Asp Arg His Arg  Lys Ser Ser Asp Lys  Gln His Pro 
    1160                 1165                 1170             


Glu Arg  Gln Lys Asp Lys Glu  Pro Arg Asp Arg Arg  Lys Asp Arg 
    1175                 1180                 1185             


Gly Ala  Ala Asp Ala Gly Arg  Asp Lys Lys Glu Lys  Val Phe Glu 
    1190                 1195                 1200             


Lys His  Lys Glu Lys Lys Asp  Lys Glu Ser Thr Glu  Lys Tyr Lys 
    1205                 1210                 1215             


Asp Arg  Lys Asp Arg Ala Ser  Val Asp Ser Thr Gln  Asp Lys Lys 
    1220                 1225                 1230             


Asn Lys  Gln Lys Leu Pro Glu  Lys Ala Glu Lys Lys  His Ala Ala 
    1235                 1240                 1245             


Glu Asp  Lys Ala Lys Ser Lys  His Lys Glu Lys Ser  Asp Lys Glu 
    1250                 1255                 1260             


His Ser  Lys Glu Arg Lys Ser  Ser Arg Ser Ala Asp  Ala Glu Lys 
    1265                 1270                 1275             


Ser Leu  Leu Glu Lys Leu Glu  Glu Glu Ala Leu His  Glu Tyr Arg 
    1280                 1285                 1290             


Glu Asp  Ser Asn Asp Lys Ile  Ser Glu Val Ser Ser  Asp Ser Phe 
    1295                 1300                 1305             


Thr Asp  Arg Gly Gln Glu Pro  Gly Leu Thr Ala Phe  Leu Glu Val 
    1310                 1315                 1320             


Ser Phe  Thr Glu Pro Pro Gly  Asp Asp Lys Pro Arg  Glu Ser Ala 
    1325                 1330                 1335             


Cys Leu  Pro Glu Lys Leu Lys  Glu Lys Glu Arg His  Arg His Ser 
    1340                 1345                 1350             


Ser Ser  Ser Ser Lys Lys Ser  His Asp Arg Glu Arg  Ala Lys Lys 
    1355                 1360                 1365             


Glu Lys  Ala Glu Lys Lys Glu  Lys Gly Glu Asp Tyr  Lys Glu Gly 
    1370                 1375                 1380             


Gly Ser  Arg Lys Asp Ser Gly  Gln Tyr Glu Lys Asp  Phe Leu Glu 
    1385                 1390                 1395             


Ala Asp  Ala Tyr Gly Val Ser  Tyr Asn Met Lys Ala  Asp Ile Glu 
    1400                 1405                 1410             


Asp Glu  Leu Asp Lys Thr Ile  Glu Leu Phe Ser Thr  Glu Lys Lys 
    1415                 1420                 1425             


Asp Lys  Asn Asp Ser Glu Arg  Glu Pro Ser Lys Lys  Ile Glu Lys 
    1430                 1435                 1440             


Glu Leu  Lys Pro Tyr Gly Ser  Ser Ala Ile Asn Ile  Leu Lys Glu 
    1445                 1450                 1455             


Lys Lys  Lys Arg Glu Lys His  Arg Glu Lys Trp Arg  Asp Glu Lys 
    1460                 1465                 1470             


Glu Arg  His Arg Asp Arg His  Ala Asp Gly Leu Leu  Arg His His 
    1475                 1480                 1485             


Arg Asp  Glu Leu Leu Arg His  His Arg Asp Glu Gln  Lys Pro Ala 
    1490                 1495                 1500             


Thr Arg  Asp Lys Asp Ser Pro  Pro Arg Val Leu Lys  Asp Lys Ser 
    1505                 1510                 1515             


Arg Asp  Glu Gly Pro Arg Leu  Gly Asp Ala Lys Leu  Lys Glu Lys 
    1520                 1525                 1530             


Phe Lys  Asp Gly Ala Glu Lys  Glu Lys Gly Asp Pro  Val Lys Met 
    1535                 1540                 1545             


Ser Asn  Gly Asn Asp Lys Val  Ala Pro Ser Lys Asp  Pro Gly Lys 
    1550                 1555                 1560             


Lys Asp  Ala Arg Pro Arg Glu  Lys Leu Leu Gly Asp  Gly Asp Leu 
    1565                 1570                 1575             


Met Met  Thr Ser Phe Glu Arg  Met Leu Ser Gln Lys  Asp Leu Glu 
    1580                 1585                 1590             


Ile Glu  Glu Arg His Lys Arg  His Lys Glu Arg Met  Lys Gln Met 
    1595                 1600                 1605             


Glu Lys  Leu Arg His Arg Ser  Gly Asp Pro Lys Leu  Lys Glu Lys 
    1610                 1615                 1620             


Ala Lys  Pro Ala Asp Asp Gly  Arg Lys Lys Gly Leu  Asp Ile Pro 
    1625                 1630                 1635             


Ala Lys  Lys Pro Pro Gly Leu  Asp Pro Pro Phe Lys  Asp Lys Lys 
    1640                 1645                 1650             


Leu Lys  Glu Ser Thr Pro Ile  Pro Pro Ala Ala Glu  Asn Lys Leu 
    1655                 1660                 1665             


His Pro  Ala Ser Gly Ala Asp  Ser Lys Asp Trp Leu  Ala Gly Pro 
    1670                 1675                 1680             


His Met  Lys Glu Val Leu Pro  Ala Ser Pro Arg Pro  Asp Gln Ser 
    1685                 1690                 1695             


Arg Pro  Thr Gly Val Pro Thr  Pro Thr Ser Val Leu  Ser Cys Pro 
    1700                 1705                 1710             


Ser Tyr  Glu Glu Val Met His  Thr Pro Arg Thr Pro  Ser Cys Ser 
    1715                 1720                 1725             


Ala Asp  Asp Tyr Ala Asp Leu  Val Phe Asp Cys Ala  Asp Ser Gln 
    1730                 1735                 1740             


His Ser  Thr Pro Val Pro Thr  Ala Pro Thr Ser Ala  Cys Ser Pro 
    1745                 1750                 1755             


Ser Phe  Phe Asp Arg Phe Ser  Val Ala Ser Ser Gly  Leu Ser Glu 
    1760                 1765                 1770             


Asn Ala  Ser Gln Ala Pro Ala  Arg Pro Leu Ser Thr  Asn Leu Tyr 
    1775                 1780                 1785             


Arg Ser  Val Ser Val Asp Ile  Arg Arg Thr Pro Glu  Glu Glu Phe 
    1790                 1795                 1800             


Ser Val  Gly Asp Lys Leu Phe  Arg Gln Gln Ser Val  Pro Ala Ala 
    1805                 1810                 1815             


Ser Ser  Tyr Asp Ser Pro Met  Pro Pro Ser Met Glu  Asp Arg Ala 
    1820                 1825                 1830             


Pro Leu  Pro Pro Val Pro Ala  Glu Lys Phe Ala Cys  Leu Ser Pro 
    1835                 1840                 1845             


Gly Tyr  Tyr Ser Pro Asp Tyr  Gly Leu Pro Ser Pro  Lys Val Asp 
    1850                 1855                 1860             


Ala Leu  His Cys Pro Pro Ala  Ala Val Val Thr Val  Thr Pro Ser 
    1865                 1870                 1875             


Pro Glu  Gly Val Phe Ser Ser  Leu Gln Ala Lys Pro  Ser Pro Ser 
    1880                 1885                 1890             


Pro Arg  Ala Glu Leu Leu Val  Pro Ser Leu Glu Gly  Ala Leu Pro 
    1895                 1900                 1905             


Pro Asp  Leu Asp Thr Ser Glu  Asp Gln Gln Ala Thr  Ala Ala Ile 
    1910                 1915                 1920             


Ile Pro  Pro Glu Pro Ser Tyr  Leu Glu Pro Leu Asp  Glu Gly Pro 
    1925                 1930                 1935             


Phe Ser  Ala Val Ile Thr Glu  Glu Pro Val Glu Trp  Ala His Pro 
    1940                 1945                 1950             


Ser Glu  Gln Ala Leu Ala Ser  Ser Leu Ile Gly Gly  Thr Ser Glu 
    1955                 1960                 1965             


Asn Pro  Val Ser Trp Pro Val  Gly Ser Asp Leu Leu  Leu Lys Ser 
    1970                 1975                 1980             


Pro Gln  Arg Phe Pro Glu Ser  Pro Lys Arg Phe Cys  Pro Ala Asp 
    1985                 1990                 1995             


Pro Leu  His Ser Ala Ala Pro  Gly Pro Phe Ser Ala  Ser Glu Ala 
    2000                 2005                 2010             


Pro Tyr  Pro Ala Pro Pro Ala  Ser Pro Ala Pro Tyr  Ala Leu Pro 
    2015                 2020                 2025             


Val Ala  Glu Pro Gly Leu Glu  Asp Val Lys Asp Gly  Val Asp Ala 
    2030                 2035                 2040             


Val Pro  Ala Ala Ile Ser Thr  Ser Glu Ala Ala Pro  Tyr Ala Pro 
    2045                 2050                 2055             


Pro Ser  Gly Leu Glu Ser Phe  Phe Ser Asn Cys Lys  Ser Leu Pro 
    2060                 2065                 2070             


Glu Ala  Pro Leu Asp Val Ala  Pro Glu Pro Ala Cys  Val Ala Ala 
    2075                 2080                 2085             


Val Ala  Gln Val Glu Ala Leu  Gly Pro Leu Glu Asn  Ser Phe Leu 
    2090                 2095                 2100             


Asp Gly  Ser Arg Gly Leu Ser  His Leu Gly Gln Val  Glu Pro Val 
    2105                 2110                 2115             


Pro Trp  Ala Asp Ala Phe Ala  Gly Pro Glu Asp Asp  Leu Asp Leu 
    2120                 2125                 2130             


Gly Pro  Phe Ser Leu Pro Glu  Leu Pro Leu Gln Thr  Lys Asp Ala 
    2135                 2140                 2145             


Ala Asp  Gly Glu Ala Glu Pro  Val Glu Glu Ser Leu  Ala Pro Pro 
    2150                 2155                 2160             


Glu Glu  Met Pro Pro Gly Ala  Pro Gly Val Ile Asn  Gly Gly Asp 
    2165                 2170                 2175             


Val Ser  Thr Val Val Ala Glu  Glu Pro Pro Ala Leu  Pro Pro Asp 
    2180                 2185                 2190             


Gln Ala  Ser Thr Arg Leu Pro  Ala Glu Leu Glu Pro  Glu Pro Ser 
    2195                 2200                 2205             


Gly Glu  Pro Lys Leu Asp Val  Ala Leu Glu Ala Ala  Val Glu Ala 
    2210                 2215                 2220             


Glu Thr  Val Pro Glu Glu Arg  Ala Arg Gly Asp Pro  Asp Ser Ser 
    2225                 2230                 2235             


Val Glu  Pro Ala Pro Val Pro  Pro Glu Gln Arg Pro  Leu Gly Ser 
    2240                 2245                 2250             


Gly Asp  Gln Gly Ala Glu Ala  Glu Gly Pro Pro Ala  Ala Ser Leu 
    2255                 2260                 2265             


Cys Ala  Pro Asp Gly Pro Ala  Pro Asn Thr Val Ala  Gln Ala Gln 
    2270                 2275                 2280             


Ala Ala  Asp Gly Ala Gly Pro  Glu Asp Asp Thr Glu  Ala Ser Arg 
    2285                 2290                 2295             


Ala Ala  Ala Pro Ala Glu Gly  Pro Pro Gly Gly Ile  Gln Pro Glu 
    2300                 2305                 2310             


Ala Ala  Glu Pro Lys Pro Thr  Ala Glu Ala Pro Lys  Ala Pro Arg 
    2315                 2320                 2325             


Val Glu  Glu Ile Pro Gln Arg  Met Thr Arg Asn Arg  Ala Gln Met 
    2330                 2335                 2340             


Leu Ala  Asn Gln Ser Lys Gln  Gly Pro Pro Pro Ser  Glu Lys Glu 
    2345                 2350                 2355             


Cys Ala  Pro Thr Pro Ala Pro  Val Thr Arg Ala Lys  Ala Arg Gly 
    2360                 2365                 2370             


Ser Glu  Asp Asp Asp Ala Gln  Ala Gln His Pro Arg  Lys Arg Arg 
    2375                 2380                 2385             


Phe Gln  Arg Ser Thr Gln Gln  Leu Gln Gln Gln Leu  Asn Thr Ser 
    2390                 2395                 2400             


Thr Gln  Gln Thr Arg Glu Val  Ile Gln Gln Thr Leu  Ala Ala Ile 
    2405                 2410                 2415             


Val Asp  Ala Ile Lys Leu Asp  Ala Ile Glu Pro Tyr  His Ser Asp 
    2420                 2425                 2430             


Arg Ala  Asn Pro Tyr Phe Glu  Tyr Leu Gln Ile Arg  Lys Lys Ile 
    2435                 2440                 2445             


Glu Glu  Lys Arg Lys Ile Leu  Cys Cys Ile Thr Pro  Gln Ala Pro 
    2450                 2455                 2460             


Gln Cys  Tyr Ala Glu Tyr Val  Thr Tyr Thr Gly Ser  Tyr Leu Leu 
    2465                 2470                 2475             


Asp Gly  Lys Pro Leu Ser Lys  Leu His Ile Pro Val  Ile Ala Pro 
    2480                 2485                 2490             


Pro Pro  Ser Leu Ala Glu Pro  Leu Lys Glu Leu Phe  Arg Gln Gln 
    2495                 2500                 2505             


Glu Ala  Val Arg Gly Lys Leu  Arg Leu Gln His Ser  Ile Glu Arg 
    2510                 2515                 2520             


Glu Lys  Leu Ile Val Ser Cys  Glu Gln Glu Ile Leu  Arg Val His 
    2525                 2530                 2535             


Cys Arg  Ala Ala Arg Thr Ile  Ala Asn Gln Ala Val  Pro Phe Ser 
    2540                 2545                 2550             


Ala Cys  Thr Met Leu Leu Asp  Ser Glu Val Tyr Asn  Met Pro Leu 
    2555                 2560                 2565             


Glu Ser  Gln Gly Asp Glu Asn  Lys Ser Val Arg Asp  Arg Phe Asn 
    2570                 2575                 2580             


Ala Arg  Gln Phe Ile Ser Trp  Leu Gln Asp Val Asp  Asp Lys Tyr 
    2585                 2590                 2595             


Asp Arg  Met Lys Thr Cys Leu  Leu Met Arg Gln Gln  His Glu Ala 
    2600                 2605                 2610             


Ala Ala  Leu Asn Ala Val Gln  Arg Met Glu Trp Gln  Leu Lys Val 
    2615                 2620                 2625             


Gln Glu  Leu Asp Pro Ala Gly  His Lys Ser Leu Cys  Val Asn Glu 
    2630                 2635                 2640             


Val Pro  Ser Phe Tyr Val Pro  Met Val Asp Val Asn  Asp Asp Phe 
    2645                 2650                 2655             


Val Leu  Leu Pro Ala 
    2660             


<210>  537
<211>  2039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD12__Homo_sapiens__NP_001190985

<400>  537

Met Pro Lys Ser Gly Phe Thr Lys Pro Ile Gln Ser Glu Asn Ser Asp 
1               5                   10                  15      


Ser Asp Ser Asn Met Val Glu Lys Pro Tyr Gly Arg Lys Ser Lys Asp 
            20                  25                  30          


Lys Ile Ala Ser Tyr Ser Lys Thr Pro Lys Ile Glu Arg Ser Asp Val 
        35                  40                  45              


Ser Lys Glu Met Lys Glu Lys Ser Ser Met Lys Arg Lys Leu Pro Phe 
    50                  55                  60                  


Thr Ile Ser Pro Ser Arg Asn Glu Glu Arg Asp Ser Asp Thr Glu Lys 
65                  70                  75                  80  


Glu Gly Pro Glu Lys Lys Lys Thr Lys Lys Glu Ala Gly Asn Lys Lys 
                85                  90                  95      


Ser Thr Pro Val Ser Ile Leu Phe Gly Tyr Pro Leu Ser Glu Arg Lys 
            100                 105                 110         


Gln Met Ala Leu Leu Met Gln Met Thr Ala Arg Asp Asn Ser Pro Asp 
        115                 120                 125             


Ser Thr Pro Asn His Pro Ser Gln Thr Thr Pro Ala Gln Lys Lys Thr 
    130                 135                 140                 


Pro Ser Ser Ser Ser Arg Gln Lys Asp Lys Val Asn Lys Arg Asn Glu 
145                 150                 155                 160 


Arg Gly Glu Thr Pro Leu His Met Ala Ala Ile Arg Gly Asp Val Lys 
                165                 170                 175     


Gln Val Lys Glu Leu Ile Ser Leu Gly Ala Asn Val Asn Val Lys Asp 
            180                 185                 190         


Phe Ala Gly Trp Thr Pro Leu His Glu Ala Cys Asn Val Gly Tyr Tyr 
        195                 200                 205             


Asp Val Ala Lys Ile Leu Ile Ala Ala Gly Ala Asp Val Asn Thr Gln 
    210                 215                 220                 


Gly Leu Asp Asp Asp Thr Pro Leu His Asp Ser Ala Ser Ser Gly His 
225                 230                 235                 240 


Arg Asp Ile Val Lys Leu Leu Leu Arg His Gly Gly Asn Pro Phe Gln 
                245                 250                 255     


Ala Asn Lys His Gly Glu Arg Pro Val Asp Val Ala Glu Thr Glu Glu 
            260                 265                 270         


Leu Glu Leu Leu Leu Lys Arg Glu Val Pro Leu Ser Asp Asp Asp Glu 
        275                 280                 285             


Ser Tyr Thr Asp Ser Glu Glu Ala Gln Ser Val Asn Pro Ser Ser Val 
    290                 295                 300                 


Asp Glu Asn Ile Asp Ser Glu Thr Glu Lys Asp Ser Leu Ile Cys Glu 
305                 310                 315                 320 


Ser Lys Gln Ile Leu Pro Ser Lys Thr Pro Leu Pro Ser Ala Leu Asp 
                325                 330                 335     


Glu Tyr Glu Phe Lys Asp Asp Asp Asp Glu Glu Ile Asn Lys Met Ile 
            340                 345                 350         


Asp Asp Arg His Ile Leu Arg Lys Glu Gln Arg Lys Glu Asn Glu Pro 
        355                 360                 365             


Glu Ala Glu Lys Thr His Leu Phe Ala Lys Gln Glu Lys Ala Phe Tyr 
    370                 375                 380                 


Pro Lys Ser Phe Lys Ser Lys Lys Gln Lys Pro Ser Arg Val Leu Tyr 
385                 390                 395                 400 


Ser Ser Thr Glu Ser Ser Asp Glu Glu Ala Leu Gln Asn Lys Lys Ile 
                405                 410                 415     


Ser Thr Ser Cys Ser Val Ile Pro Glu Thr Ser Asn Ser Asp Met Gln 
            420                 425                 430         


Thr Lys Lys Glu Tyr Val Val Ser Gly Glu His Lys Gln Lys Gly Lys 
        435                 440                 445             


Val Lys Arg Lys Leu Lys Asn Gln Asn Lys Asn Lys Glu Asn Gln Glu 
    450                 455                 460                 


Leu Lys Gln Glu Lys Glu Gly Lys Glu Asn Thr Arg Ile Thr Asn Leu 
465                 470                 475                 480 


Thr Val Asn Thr Gly Leu Asp Cys Ser Glu Lys Thr Arg Glu Glu Gly 
                485                 490                 495     


Asn Phe Arg Lys Ser Phe Ser Pro Lys Asp Asp Thr Ser Leu His Leu 
            500                 505                 510         


Phe His Ile Ser Thr Gly Lys Ser Pro Lys His Ser Cys Gly Leu Ser 
        515                 520                 525             


Glu Lys Gln Ser Thr Pro Leu Lys Gln Glu His Thr Lys Thr Cys Leu 
    530                 535                 540                 


Ser Pro Gly Ser Ser Glu Met Ser Leu Gln Pro Asp Leu Val Arg Tyr 
545                 550                 555                 560 


Asp Asn Thr Glu Ser Glu Phe Leu Pro Glu Ser Ser Ser Val Lys Ser 
                565                 570                 575     


Cys Lys His Lys Glu Lys Ser Lys His Gln Lys Asp Phe His Leu Glu 
            580                 585                 590         


Phe Gly Glu Lys Ser Asn Ala Lys Ile Lys Asp Glu Asp His Ser Pro 
        595                 600                 605             


Thr Phe Glu Asn Ser Asp Cys Thr Leu Lys Lys Met Asp Lys Glu Gly 
    610                 615                 620                 


Lys Thr Leu Lys Lys His Lys Leu Lys His Lys Glu Arg Glu Lys Glu 
625                 630                 635                 640 


Lys His Lys Lys Glu Ile Glu Gly Glu Lys Glu Lys Tyr Lys Thr Lys 
                645                 650                 655     


Asp Ser Ala Lys Glu Leu Gln Arg Ser Val Glu Phe Asp Arg Glu Phe 
            660                 665                 670         


Trp Lys Glu Asn Phe Phe Lys Ser Asp Glu Thr Glu Asp Leu Phe Leu 
        675                 680                 685             


Asn Met Glu His Glu Ser Leu Thr Leu Glu Lys Lys Ser Lys Leu Glu 
    690                 695                 700                 


Lys Asn Ile Lys Asp Asp Lys Ser Thr Lys Glu Lys His Val Ser Lys 
705                 710                 715                 720 


Glu Arg Asn Phe Lys Glu Glu Arg Asp Lys Ile Lys Lys Glu Ser Glu 
                725                 730                 735     


Lys Ser Phe Arg Glu Glu Lys Ile Lys Asp Leu Lys Glu Glu Arg Glu 
            740                 745                 750         


Asn Ile Pro Thr Asp Lys Asp Ser Glu Phe Thr Ser Leu Gly Met Ser 
        755                 760                 765             


Ala Ile Glu Glu Ser Ile Gly Leu His Leu Val Glu Lys Glu Ile Asp 
    770                 775                 780                 


Ile Glu Lys Gln Glu Lys His Ile Lys Glu Ser Lys Glu Lys Pro Glu 
785                 790                 795                 800 


Lys Arg Ser Gln Ile Lys Glu Lys Asp Ile Glu Lys Met Glu Arg Lys 
                805                 810                 815     


Thr Phe Glu Lys Glu Lys Lys Ile Lys His Glu His Lys Ser Glu Lys 
            820                 825                 830         


Asp Lys Leu Asp Leu Ser Glu Cys Val Asp Lys Ile Lys Glu Lys Asp 
        835                 840                 845             


Lys Leu Tyr Ser His His Thr Glu Lys Cys His Lys Glu Gly Glu Lys 
    850                 855                 860                 


Ser Lys Asn Thr Ala Ala Ile Lys Lys Thr Asp Asp Arg Glu Lys Ser 
865                 870                 875                 880 


Arg Glu Lys Met Asp Arg Lys His Asp Lys Glu Lys Pro Glu Lys Glu 
                885                 890                 895     


Arg His Leu Ala Glu Ser Lys Glu Lys His Leu Met Glu Lys Lys Asn 
            900                 905                 910         


Lys Gln Ser Asp Asn Ser Glu Tyr Ser Lys Ser Glu Lys Gly Lys Asn 
        915                 920                 925             


Lys Glu Lys Asp Arg Glu Leu Asp Lys Lys Glu Lys Ser Arg Asp Lys 
    930                 935                 940                 


Glu Ser Ile Asn Ile Thr Asn Ser Lys His Ile Gln Glu Glu Lys Lys 
945                 950                 955                 960 


Ser Ser Ile Val Asp Gly Asn Lys Ala Gln His Glu Lys Pro Leu Ser 
                965                 970                 975     


Leu Lys Glu Lys Thr Lys Asp Glu Pro Leu Lys Thr Pro Asp Gly Lys 
            980                 985                 990         


Glu Lys Asp Lys Lys Asp Lys Asp  Ile Asp Arg Tyr Lys  Glu Arg Asp 
        995                 1000                 1005             


Lys His  Lys Asp Lys Ile Gln  Ile Asn Ser Leu Leu  Lys Leu Lys 
    1010                 1015                 1020             


Ser Glu  Ala Asp Lys Pro Lys  Pro Lys Ser Ser Pro  Ala Ser Lys 
    1025                 1030                 1035             


Asp Thr  Arg Pro Lys Glu Lys  Arg Leu Val Asn Asp  Asp Leu Met 
    1040                 1045                 1050             


Gln Thr  Ser Phe Glu Arg Met  Leu Ser Leu Lys Asp  Leu Glu Ile 
    1055                 1060                 1065             


Glu Gln  Trp His Lys Lys His  Lys Glu Lys Ile Lys  Gln Lys Glu 
    1070                 1075                 1080             


Lys Glu  Arg Leu Arg Asn Arg  Asn Cys Leu Glu Leu  Lys Ile Lys 
    1085                 1090                 1095             


Asp Lys  Glu Lys Thr Lys His  Thr Pro Thr Glu Ser  Lys Asn Lys 
    1100                 1105                 1110             


Glu Leu  Thr Arg Ser Lys Ser  Ser Glu Val Thr Asp  Ala Tyr Thr 
    1115                 1120                 1125             


Lys Glu  Lys Gln Pro Lys Asp  Ala Val Ser Asn Arg  Ser Gln Ser 
    1130                 1135                 1140             


Val Asp  Thr Lys Asn Val Met  Thr Leu Gly Lys Ser  Ser Phe Val 
    1145                 1150                 1155             


Ser Asp  Asn Ser Leu Asn Arg  Ser Pro Arg Ser Glu  Asn Glu Lys 
    1160                 1165                 1170             


Pro Gly  Leu Ser Ser Arg Ser  Val Ser Met Ile Ser  Val Ala Ser 
    1175                 1180                 1185             


Ser Glu  Asp Ser Cys His Thr  Thr Val Thr Thr Pro  Arg Pro Pro 
    1190                 1195                 1200             


Val Glu  Tyr Asp Ser Asp Phe  Met Leu Glu Ser Ser  Glu Ser Gln 
    1205                 1210                 1215             


Met Ser  Phe Ser Gln Ser Pro  Phe Leu Ser Ile Ala  Lys Ser Pro 
    1220                 1225                 1230             


Ala Leu  His Glu Arg Glu Leu  Asp Ser Leu Ala Asp  Leu Pro Glu 
    1235                 1240                 1245             


Arg Ile  Lys Pro Pro Tyr Ala  Asn Arg Leu Ser Thr  Ser His Leu 
    1250                 1255                 1260             


Arg Ser  Ser Ser Val Glu Asp  Val Lys Leu Ile Ile  Ser Glu Gly 
    1265                 1270                 1275             


Arg Pro  Thr Ile Glu Val Arg  Arg Cys Ser Met Pro  Ser Val Ile 
    1280                 1285                 1290             


Cys Glu  His Thr Lys Gln Phe  Gln Thr Ile Ser Glu  Glu Ser Asn 
    1295                 1300                 1305             


Gln Gly  Ser Leu Leu Thr Val  Pro Gly Asp Thr Ser  Pro Ser Pro 
    1310                 1315                 1320             


Lys Pro  Glu Val Phe Ser Asn  Val Pro Glu Arg Asp  Leu Ser Asn 
    1325                 1330                 1335             


Val Ser  Asn Ile His Ser Ser  Phe Ala Thr Ser Pro  Thr Gly Ala 
    1340                 1345                 1350             


Ser Asn  Ser Lys Tyr Val Ser  Ala Asp Arg Asn Leu  Ile Lys Asn 
    1355                 1360                 1365             


Thr Ala  Pro Val Asn Thr Val  Met Asp Ser Pro Val  His Leu Glu 
    1370                 1375                 1380             


Pro Ser  Ser Gln Val Gly Val  Ile Gln Asn Lys Ser  Trp Glu Met 
    1385                 1390                 1395             


Pro Val  Asp Arg Leu Glu Thr  Leu Ser Thr Arg Asp  Phe Ile Cys 
    1400                 1405                 1410             


Pro Asn  Ser Asn Ile Pro Asp  Gln Glu Ser Ser Leu  Gln Ser Phe 
    1415                 1420                 1425             


Cys Asn  Ser Glu Asn Lys Val  Leu Lys Glu Asn Ala  Asp Phe Leu 
    1430                 1435                 1440             


Ser Leu  Arg Gln Thr Glu Leu  Pro Gly Asn Ser Cys  Ala Gln Asp 
    1445                 1450                 1455             


Pro Ala  Ser Phe Met Pro Pro  Gln Gln Pro Cys Ser  Phe Pro Ser 
    1460                 1465                 1470             


Gln Ser  Leu Ser Asp Ala Glu  Ser Ile Ser Lys His  Met Ser Leu 
    1475                 1480                 1485             


Ser Tyr  Val Ala Asn Gln Glu  Pro Gly Ile Leu Gln  Gln Lys Asn 
    1490                 1495                 1500             


Ala Val  Gln Ile Ile Ser Ser  Ala Leu Asp Thr Asp  Asn Glu Ser 
    1505                 1510                 1515             


Thr Lys  Asp Thr Glu Asn Thr  Phe Val Leu Gly Asp  Val Gln Lys 
    1520                 1525                 1530             


Thr Asp  Ala Phe Val Pro Val  Tyr Ser Asp Ser Thr  Ile Gln Glu 
    1535                 1540                 1545             


Ala Ser  Pro Asn Phe Glu Lys  Ala Tyr Thr Leu Pro  Val Leu Pro 
    1550                 1555                 1560             


Ser Glu  Lys Asp Phe Asn Gly  Ser Asp Ala Ser Thr  Gln Leu Asn 
    1565                 1570                 1575             


Thr His  Tyr Ala Phe Ser Lys  Leu Thr Tyr Lys Ser  Ser Ser Gly 
    1580                 1585                 1590             


His Glu  Val Glu Asn Ser Thr  Thr Asp Thr Gln Val  Ile Ser His 
    1595                 1600                 1605             


Glu Lys  Glu Asn Lys Leu Glu  Ser Leu Val Leu Thr  His Leu Ser 
    1610                 1615                 1620             


Arg Cys  Asp Ser Asp Leu Cys  Glu Met Asn Ala Gly  Met Pro Lys 
    1625                 1630                 1635             


Gly Asn  Leu Asn Glu Gln Asp  Pro Lys His Cys Pro  Glu Ser Glu 
    1640                 1645                 1650             


Lys Cys  Leu Leu Ser Ile Glu  Asp Glu Glu Ser Gln  Gln Ser Ile 
    1655                 1660                 1665             


Leu Ser  Ser Leu Glu Asn His  Ser Gln Gln Ser Thr  Gln Pro Glu 
    1670                 1675                 1680             


Met His  Lys Tyr Gly Gln Leu  Val Lys Val Glu Leu  Glu Glu Asn 
    1685                 1690                 1695             


Ala Glu  Asp Asp Lys Thr Glu  Asn Gln Ile Pro Gln  Arg Met Thr 
    1700                 1705                 1710             


Arg Asn  Lys Ala Asn Thr Met  Ala Asn Gln Ser Lys  Gln Ile Leu 
    1715                 1720                 1725             


Ala Ser  Cys Thr Leu Leu Ser  Glu Lys Asp Ser Glu  Ser Ser Ser 
    1730                 1735                 1740             


Pro Arg  Gly Arg Ile Arg Leu  Thr Glu Asp Asp Asp  Pro Gln Ile 
    1745                 1750                 1755             


His His  Pro Arg Lys Arg Lys  Val Ser Arg Val Pro  Gln Pro Val 
    1760                 1765                 1770             


Gln Val  Ser Pro Ser Leu Leu  Gln Ala Lys Glu Lys  Thr Gln Gln 
    1775                 1780                 1785             


Ser Leu  Ala Ala Ile Val Asp  Ser Leu Lys Leu Asp  Glu Ile Gln 
    1790                 1795                 1800             


Pro Tyr  Ser Ser Glu Arg Ala  Asn Pro Tyr Phe Glu  Tyr Leu His 
    1805                 1810                 1815             


Ile Arg  Lys Lys Ile Glu Glu  Lys Arg Lys Leu Leu  Cys Ser Val 
    1820                 1825                 1830             


Ile Pro  Gln Ala Pro Gln Tyr  Tyr Asp Glu Tyr Val  Thr Phe Asn 
    1835                 1840                 1845             


Gly Ser  Tyr Leu Leu Asp Gly  Asn Pro Leu Ser Lys  Ile Cys Ile 
    1850                 1855                 1860             


Pro Thr  Ile Thr Pro Pro Pro  Ser Leu Ser Asp Pro  Leu Lys Glu 
    1865                 1870                 1875             


Leu Phe  Arg Gln Gln Glu Val  Val Arg Met Lys Leu  Arg Leu Gln 
    1880                 1885                 1890             


His Ser  Ile Glu Arg Glu Lys  Leu Ile Val Ser Asn  Glu Gln Glu 
    1895                 1900                 1905             


Val Leu  Arg Val His Tyr Arg  Ala Ala Arg Thr Leu  Ala Asn Gln 
    1910                 1915                 1920             


Thr Leu  Pro Phe Ser Ala Cys  Thr Val Leu Leu Asp  Ala Glu Val 
    1925                 1930                 1935             


Tyr Asn  Val Pro Leu Asp Ser  Gln Ser Asp Asp Ser  Lys Thr Ser 
    1940                 1945                 1950             


Val Arg  Asp Arg Phe Asn Ala  Arg Gln Phe Met Ser  Trp Leu Gln 
    1955                 1960                 1965             


Asp Val  Asp Asp Lys Phe Asp  Lys Leu Lys Thr Cys  Leu Leu Met 
    1970                 1975                 1980             


Arg Gln  Gln His Glu Ala Ala  Ala Leu Asn Ala Val  Gln Arg Leu 
    1985                 1990                 1995             


Glu Trp  Gln Leu Lys Leu Gln  Glu Leu Asp Pro Ala  Thr Tyr Lys 
    2000                 2005                 2010             


Ser Ile  Ser Ile Tyr Glu Ile  Gln Glu Phe Tyr Val  Pro Leu Val 
    2015                 2020                 2025             


Asp Val  Asn Asp Asp Phe Glu  Leu Thr Pro Ile 
    2030                 2035                 


<210>  538
<211>  992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD18A__Homo_sapiens__NP_671728

<400>  538

Met Arg Lys Leu Phe Ser Phe Gly Arg Arg Leu Gly Gln Ala Leu Leu 
1               5                   10                  15      


Ser Ser Met Asp Gln Glu Tyr Ala Gly Pro Gly Tyr Asp Ile Arg Asp 
            20                  25                  30          


Trp Glu Leu Arg Lys Ile His Arg Ala Ala Ile Lys Gly Asp Ala Ala 
        35                  40                  45              


Glu Val Glu Arg Cys Leu Thr Arg Arg Phe Arg Asp Leu Asp Ala Arg 
    50                  55                  60                  


Asp Arg Lys Asp Arg Thr Val Leu His Leu Ala Cys Ala His Gly Arg 
65                  70                  75                  80  


Val Gln Val Val Thr Leu Leu Leu His Arg Arg Cys Gln Ile Asp Ile 
                85                  90                  95      


Cys Asp Arg Leu Asn Arg Thr Pro Leu Met Lys Ala Val His Ser Gln 
            100                 105                 110         


Glu Glu Ala Cys Ala Ile Val Leu Leu Glu Cys Gly Ala Asn Pro Asn 
        115                 120                 125             


Ile Glu Asp Ile Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Asn 
    130                 135                 140                 


Lys Gly Thr Ser Leu Ala Glu Arg Leu Leu Ser His His Ala Asn Ile 
145                 150                 155                 160 


Glu Ala Leu Asn Lys Glu Gly Asn Thr Pro Leu Leu Phe Ala Ile Asn 
                165                 170                 175     


Ser Arg Arg Gln His Met Val Glu Phe Leu Leu Lys Asn Gln Ala Asn 
            180                 185                 190         


Ile His Ala Val Asp Asn Phe Lys Arg Thr Ala Leu Ile Leu Ala Val 
        195                 200                 205             


Gln His Asn Leu Ser Ser Ile Val Thr Leu Leu Leu Gln Gln Asn Ile 
    210                 215                 220                 


Arg Ile Ser Ser Gln Asp Met Phe Gly Gln Thr Ala Glu Asp Tyr Ala 
225                 230                 235                 240 


Leu Cys Ser Asp Leu Arg Ser Ile Arg Gln Gln Ile Leu Glu His Lys 
                245                 250                 255     


Asn Lys Met Leu Lys Asn His Leu Arg Asn Asp Asn Gln Glu Thr Ala 
            260                 265                 270         


Ala Met Lys Pro Ala Asn Leu Lys Lys Arg Lys Glu Arg Ala Lys Ala 
        275                 280                 285             


Glu His Asn Leu Lys Val Ala Ser Glu Glu Lys Gln Glu Arg Leu Gln 
    290                 295                 300                 


Arg Ser Glu Asn Lys Gln Pro Gln Asp Ser Gln Ser Tyr Gly Lys Lys 
305                 310                 315                 320 


Lys Asp Ala Met Tyr Gly Asn Phe Met Leu Lys Lys Asp Ile Ala Met 
                325                 330                 335     


Leu Lys Glu Glu Leu Tyr Ala Ile Lys Asn Asp Ser Leu Arg Lys Glu 
            340                 345                 350         


Lys Lys Tyr Ile Gln Glu Ile Lys Ser Ile Thr Glu Ile Asn Ala Asn 
        355                 360                 365             


Phe Glu Lys Ser Val Arg Leu Asn Glu Lys Met Ile Thr Lys Thr Val 
    370                 375                 380                 


Ala Arg Tyr Ser Gln Gln Leu Asn Asp Leu Lys Ala Glu Asn Ala Arg 
385                 390                 395                 400 


Leu Asn Ser Glu Leu Glu Lys Glu Lys His Asn Lys Glu Arg Leu Glu 
                405                 410                 415     


Ala Glu Val Glu Ser Leu His Ser Ser Leu Ala Thr Ala Ile Asn Glu 
            420                 425                 430         


Tyr Asn Glu Ile Val Glu Arg Lys Asp Leu Glu Leu Val Leu Trp Arg 
        435                 440                 445             


Ala Asp Asp Val Ser Arg His Glu Lys Met Gly Ser Asn Ile Ser Gln 
    450                 455                 460                 


Leu Thr Asp Lys Asn Glu Leu Leu Thr Glu Gln Val His Lys Ala Arg 
465                 470                 475                 480 


Val Lys Phe Asn Thr Leu Lys Gly Lys Leu Arg Glu Thr Arg Asp Ala 
                485                 490                 495     


Leu Arg Glu Lys Thr Leu Ala Leu Gly Ser Val Gln Leu Asp Leu Arg 
            500                 505                 510         


Gln Ala Gln His Arg Ile Lys Glu Met Lys Gln Met His Pro Asn Gly 
        515                 520                 525             


Glu Ala Lys Glu Ser Gln Ser Ile Gly Lys Gln Asn Ser Leu Glu Glu 
    530                 535                 540                 


Arg Ile Arg Gln Gln Glu Leu Glu Asn Leu Leu Leu Glu Arg Gln Leu 
545                 550                 555                 560 


Glu Asp Ala Arg Lys Glu Gly Asp Asn Lys Glu Ile Val Ile Asn Ile 
                565                 570                 575     


His Arg Asp Cys Leu Glu Asn Gly Lys Glu Asp Leu Leu Glu Glu Arg 
            580                 585                 590         


Asn Lys Glu Leu Met Lys Glu Tyr Asn Tyr Leu Lys Glu Lys Leu Leu 
        595                 600                 605             


Gln Cys Glu Lys Glu Lys Ala Glu Arg Glu Val Ile Val Arg Glu Phe 
    610                 615                 620                 


Gln Glu Glu Leu Val Asp His Leu Lys Thr Phe Ser Ile Ser Glu Ser 
625                 630                 635                 640 


Pro Leu Glu Gly Thr Ser His Cys His Ile Asn Leu Asn Glu Thr Trp 
                645                 650                 655     


Thr Ser Lys Lys Lys Leu Phe Gln Val Glu Ile Gln Pro Glu Glu Lys 
            660                 665                 670         


His Glu Glu Phe Arg Lys Leu Phe Glu Leu Ile Ser Leu Leu Asn Tyr 
        675                 680                 685             


Thr Ala Asp Gln Ile Arg Lys Lys Asn Arg Glu Leu Glu Glu Glu Ala 
    690                 695                 700                 


Thr Gly Tyr Lys Lys Cys Leu Glu Met Thr Ile Asn Met Leu Asn Ala 
705                 710                 715                 720 


Phe Ala Asn Glu Asp Phe Ser Cys His Gly Asp Leu Asn Thr Asp Gln 
                725                 730                 735     


Leu Lys Met Asp Ile Leu Phe Lys Lys Leu Lys Gln Lys Phe Asn Asp 
            740                 745                 750         


Leu Val Ala Glu Lys Glu Ala Val Ser Ser Glu Cys Val Asn Leu Ala 
        755                 760                 765             


Lys Asp Asn Glu Val Leu His Gln Glu Leu Leu Ser Met Arg Asn Val 
    770                 775                 780                 


Gln Glu Lys Cys Glu Lys Leu Glu Lys Asp Lys Lys Met Leu Glu Glu 
785                 790                 795                 800 


Glu Val Leu Asn Leu Lys Thr His Met Glu Lys Asp Met Val Glu Leu 
                805                 810                 815     


Gly Lys Leu Gln Glu Tyr Lys Ser Glu Leu Asp Glu Arg Ala Val Gln 
            820                 825                 830         


Glu Ile Glu Lys Leu Glu Glu Ile His Leu Gln Lys Gln Ala Glu Tyr 
        835                 840                 845             


Glu Lys Gln Leu Glu Gln Leu Asn Lys Asp Asn Thr Ala Ser Leu Lys 
    850                 855                 860                 


Lys Lys Glu Leu Thr Leu Lys Asp Val Glu Cys Lys Phe Ser Lys Met 
865                 870                 875                 880 


Lys Thr Ala Tyr Glu Glu Val Thr Thr Glu Leu Glu Glu Phe Lys Glu 
                885                 890                 895     


Ala Phe Ala Gly Ala Val Lys Ala Asn Asn Ser Met Ser Lys Lys Leu 
            900                 905                 910         


Met Lys Ser Asp Lys Lys Ile Ala Val Ile Ser Thr Lys Leu Phe Thr 
        915                 920                 925             


Glu Lys Gln Arg Met Lys Tyr Phe Leu Ser Thr Leu Pro Thr Arg Pro 
    930                 935                 940                 


Glu Pro Glu Leu Pro Cys Val Glu Asn Leu Asn Ser Ile Glu Leu Asn 
945                 950                 955                 960 


Arg Lys Tyr Ile Pro Lys Thr Ala Ile Arg Ile Pro Thr Ser Asn Pro 
                965                 970                 975     


Gln Thr Ser Asn Asn Cys Lys Asn Phe Leu Thr Glu Val Leu Leu Cys 
            980                 985                 990         


<210>  539
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD1__Homo_sapiens__NP_055206

<400>  539

Met Met Val Leu Lys Val Glu Glu Leu Val Thr Gly Lys Lys Asn Gly 
1               5                   10                  15      


Asn Gly Glu Ala Gly Glu Phe Leu Pro Glu Asp Phe Arg Asp Gly Glu 
            20                  25                  30          


Tyr Glu Ala Ala Val Thr Leu Glu Lys Gln Glu Asp Leu Lys Thr Leu 
        35                  40                  45              


Leu Ala His Pro Val Thr Leu Gly Glu Gln Gln Trp Lys Ser Glu Lys 
    50                  55                  60                  


Gln Arg Glu Ala Glu Leu Lys Lys Lys Lys Leu Glu Gln Arg Ser Lys 
65                  70                  75                  80  


Leu Glu Asn Leu Glu Asp Leu Glu Ile Ile Ile Gln Leu Lys Lys Arg 
                85                  90                  95      


Lys Lys Tyr Arg Lys Thr Lys Val Pro Val Val Lys Glu Pro Glu Pro 
            100                 105                 110         


Glu Ile Ile Thr Glu Pro Val Asp Val Pro Thr Phe Leu Lys Ala Ala 
        115                 120                 125             


Leu Glu Asn Lys Leu Pro Val Val Glu Lys Phe Leu Ser Asp Lys Asn 
    130                 135                 140                 


Asn Pro Asp Val Cys Asp Glu Tyr Lys Arg Thr Ala Leu His Arg Ala 
145                 150                 155                 160 


Cys Leu Glu Gly His Leu Ala Ile Val Glu Lys Leu Met Glu Ala Gly 
                165                 170                 175     


Ala Gln Ile Glu Phe Arg Asp Met Leu Glu Ser Thr Ala Ile His Trp 
            180                 185                 190         


Ala Ser Arg Gly Gly Asn Leu Asp Val Leu Lys Leu Leu Leu Asn Lys 
        195                 200                 205             


Gly Ala Lys Ile Ser Ala Arg Asp Lys Leu Leu Ser Thr Ala Leu His 
    210                 215                 220                 


Val Ala Val Arg Thr Gly His Tyr Glu Cys Ala Glu His Leu Ile Ala 
225                 230                 235                 240 


Cys Glu Ala Asp Leu Asn Ala Lys Asp Arg Glu Gly Asp Thr Pro Leu 
                245                 250                 255     


His Asp Ala Val Arg Leu Asn Arg Tyr Lys Met Ile Arg Leu Leu Ile 
            260                 265                 270         


Met Tyr Gly Ala Asp Leu Asn Ile Lys Asn Cys Ala Gly Lys Thr Pro 
        275                 280                 285             


Met Asp Leu Val Leu His Trp Gln Asn Gly Thr Lys Ala Ile Phe Asp 
    290                 295                 300                 


Ser Leu Arg Glu Asn Ser Tyr Lys Thr Ser Arg Ile Ala Thr Phe 
305                 310                 315                 


<210>  540
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD23__Homo_sapiens__NP_659431

<400>  540

Met Asp Phe Ile Ser Ile Gln Gln Leu Val Ser Gly Glu Arg Val Glu 
1               5                   10                  15      


Gly Lys Val Leu Gly Phe Gly His Gly Val Pro Asp Pro Gly Ala Trp 
            20                  25                  30          


Pro Ser Asp Trp Arg Arg Gly Pro Gln Glu Ala Val Ala Arg Glu Lys 
        35                  40                  45              


Leu Lys Leu Glu Glu Glu Lys Lys Lys Lys Leu Glu Arg Phe Asn Ser 
    50                  55                  60                  


Thr Arg Phe Asn Leu Asp Asn Leu Ala Asp Leu Glu Asn Leu Val Gln 
65                  70                  75                  80  


Arg Arg Lys Lys Arg Leu Arg His Arg Val Pro Pro Arg Lys Pro Glu 
                85                  90                  95      


Pro Leu Val Lys Pro Gln Ser Gln Ala Gln Val Glu Pro Val Gly Leu 
            100                 105                 110         


Glu Met Phe Leu Lys Ala Ala Ala Glu Asn Gln Glu Tyr Leu Ile Asp 
        115                 120                 125             


Lys Tyr Leu Thr Asp Gly Gly Asp Pro Asn Ala His Asp Lys Leu His 
    130                 135                 140                 


Arg Thr Ala Leu His Trp Ala Cys Leu Lys Gly His Ser Gln Leu Val 
145                 150                 155                 160 


Asn Lys Leu Leu Val Ala Gly Ala Thr Val Asp Ala Arg Asp Leu Leu 
                165                 170                 175     


Asp Arg Thr Pro Val Phe Trp Ala Cys Arg Gly Gly His Leu Val Ile 
            180                 185                 190         


Leu Lys Gln Leu Leu Asn Gln Gly Ala Arg Val Asn Ala Arg Asp Lys 
        195                 200                 205             


Ile Gly Ser Thr Pro Leu His Val Ala Val Arg Thr Arg His Pro Asp 
    210                 215                 220                 


Cys Leu Glu His Leu Ile Glu Cys Gly Ala His Leu Asn Ala Gln Asp 
225                 230                 235                 240 


Lys Glu Gly Asp Thr Ala Leu His Glu Ala Val Arg His Gly Ser Tyr 
                245                 250                 255     


Lys Ala Met Lys Leu Leu Leu Leu Tyr Gly Ala Glu Leu Gly Val Arg 
            260                 265                 270         


Asn Ala Ala Ser Val Thr Pro Val Gln Leu Ala Arg Asp Trp Gln Arg 
        275                 280                 285             


Gly Ile Arg Glu Ala Leu Gln Ala His Val Ala His Pro Arg Thr Arg 
    290                 295                 300                 


Cys 
305 


<210>  541
<211>  1710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD26__Homo_sapiens__NP_055730

<400>  541

Met Lys Lys Ile Phe Ser Lys Lys Gly Glu Ser Pro Leu Gly Ser Phe 
1               5                   10                  15      


Ala Arg Arg Gln Arg Ser Ser Ala Gly Gly Gly Gly Glu Pro Gly Glu 
            20                  25                  30          


Gly Ala Tyr Ser Gln Pro Gly Tyr His Val Arg Asp Arg Asp Leu Gly 
        35                  40                  45              


Lys Ile His Lys Ala Ala Ser Ala Gly Asn Val Ala Lys Val Gln Gln 
    50                  55                  60                  


Ile Leu Leu Leu Arg Lys Asn Gly Leu Asn Asp Arg Asp Lys Met Asn 
65                  70                  75                  80  


Arg Thr Ala Leu His Leu Ala Cys Ala Asn Gly His Pro Glu Val Val 
                85                  90                  95      


Thr Leu Leu Val Asp Arg Lys Cys Gln Leu Asn Val Cys Asp Asn Glu 
            100                 105                 110         


Asn Arg Thr Ala Leu Met Lys Ala Val Gln Cys Gln Glu Glu Lys Cys 
        115                 120                 125             


Ala Thr Ile Leu Leu Glu His Gly Ala Asp Pro Asn Leu Ala Asp Val 
    130                 135                 140                 


His Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Ile Ser 
145                 150                 155                 160 


Val Ala Thr Lys Leu Leu Leu Tyr Asp Ala Asn Ile Glu Ala Lys Asn 
                165                 170                 175     


Lys Asp Asp Leu Thr Pro Leu Leu Leu Ala Val Ser Gly Lys Lys Gln 
            180                 185                 190         


Gln Met Val Glu Phe Leu Ile Lys Lys Lys Ala Asn Val Asn Ala Val 
        195                 200                 205             


Asp Lys Leu Glu Ser Ser His Gln Leu Ile Ser Glu Tyr Lys Glu Glu 
    210                 215                 220                 


Arg Ile Pro Lys His Ser Ser Gln Asn Ser Asn Ser Val Asp Glu Ser 
225                 230                 235                 240 


Ser Glu Asp Ser Leu Ser Arg Leu Ser Gly Lys Pro Gly Val Asp Asp 
                245                 250                 255     


Ser Trp Pro Thr Ser Asp Asp Glu Asp Leu Asn Phe Asp Thr Lys Asn 
            260                 265                 270         


Val Pro Lys Pro Ser Leu Ala Lys Leu Met Thr Ala Ser Gln Gln Ser 
        275                 280                 285             


Arg Lys Asn Leu Glu Ala Thr Tyr Gly Thr Val Arg Thr Gly Asn Arg 
    290                 295                 300                 


Thr Leu Phe Glu Asp Arg Asp Ser Asp Ser Gln Asp Glu Val Val Val 
305                 310                 315                 320 


Glu Ser Leu Pro Thr Thr Ser Ile Lys Val Gln Cys Phe Ser His Pro 
                325                 330                 335     


Thr Tyr Gln Ser Pro Asp Leu Leu Pro Lys Pro Ser His Lys Ser Leu 
            340                 345                 350         


Ala Asn Pro Gly Leu Met Lys Glu Glu Pro Thr Lys Pro Gly Ile Ala 
        355                 360                 365             


Lys Lys Glu Asn Gly Ile Asp Ile Ile Glu Ser Ala Pro Leu Glu Gln 
    370                 375                 380                 


Thr Asn Asn Asp Asn Leu Thr Tyr Val Asp Glu Val His Lys Asn Asn 
385                 390                 395                 400 


Arg Ser Asp Met Met Ser Ala Leu Gly Leu Gly Gln Glu Glu Asp Ile 
                405                 410                 415     


Glu Ser Pro Trp Asp Ser Glu Ser Ile Ser Glu Asn Phe Pro Gln Lys 
            420                 425                 430         


Tyr Val Asp Pro Leu Ala Gly Ala Ala Asp Gly Lys Glu Lys Asn Ile 
        435                 440                 445             


Gly Asn Glu Gln Ala Glu Asp Val Phe Tyr Ile Pro Ser Cys Met Ser 
    450                 455                 460                 


Gly Ser Arg Asn Phe Lys Met Ala Lys Leu Glu Asp Thr Arg Asn Val 
465                 470                 475                 480 


Gly Met Pro Val Ala His Met Glu Ser Pro Glu Arg Tyr Leu His Leu 
                485                 490                 495     


Lys Pro Thr Ile Glu Met Lys Asp Ser Val Pro Asn Lys Ala Gly Gly 
            500                 505                 510         


Met Lys Asp Val Gln Thr Ser Lys Ala Ala Glu His Asp Leu Glu Val 
        515                 520                 525             


Ala Ser Glu Glu Glu Gln Glu Arg Glu Gly Ser Glu Asn Asn Gln Pro 
    530                 535                 540                 


Gln Val Glu Glu Glu Arg Lys Lys His Arg Asn Asn Glu Met Glu Val 
545                 550                 555                 560 


Ser Ala Asn Ile His Asp Gly Ala Thr Asp Asp Ala Glu Asp Asp Asp 
                565                 570                 575     


Asp Asp Asp Gly Leu Ile Gln Lys Arg Lys Ser Gly Glu Thr Asp His 
            580                 585                 590         


Gln Gln Phe Pro Arg Lys Glu Asn Lys Glu Tyr Ala Ser Ser Gly Pro 
        595                 600                 605             


Ala Leu Gln Met Lys Glu Val Lys Ser Thr Glu Lys Glu Lys Arg Thr 
    610                 615                 620                 


Ser Lys Glu Ser Val Asn Ser Pro Val Phe Gly Lys Ala Ser Leu Leu 
625                 630                 635                 640 


Thr Gly Gly Leu Leu Gln Val Asp Asp Asp Ser Ser Leu Ser Glu Ile 
                645                 650                 655     


Asp Glu Asp Glu Gly Arg Pro Thr Lys Lys Thr Ser Asn Glu Lys Asn 
            660                 665                 670         


Lys Val Lys Asn Gln Ile Gln Ser Met Asp Asp Val Asp Asp Leu Thr 
        675                 680                 685             


Gln Ser Ser Glu Thr Ala Ser Glu Asp Cys Glu Leu Pro His Ser Ser 
    690                 695                 700                 


Tyr Lys Asn Phe Met Leu Leu Ile Glu Gln Leu Gly Met Glu Cys Lys 
705                 710                 715                 720 


Asp Ser Val Ser Leu Leu Lys Ile Gln Asp Ala Ala Leu Ser Cys Glu 
                725                 730                 735     


Arg Leu Leu Glu Leu Lys Lys Asn His Cys Glu Leu Leu Thr Val Lys 
            740                 745                 750         


Ile Lys Lys Met Glu Asp Lys Val Asn Val Leu Gln Arg Glu Leu Ser 
        755                 760                 765             


Glu Thr Lys Glu Ile Lys Ser Gln Leu Glu His Gln Lys Val Glu Trp 
    770                 775                 780                 


Glu Arg Glu Leu Cys Ser Leu Arg Phe Ser Leu Asn Gln Glu Glu Glu 
785                 790                 795                 800 


Lys Arg Arg Asn Ala Asp Thr Leu Tyr Glu Lys Ile Arg Glu Gln Leu 
                805                 810                 815     


Arg Arg Lys Glu Glu Gln Tyr Arg Lys Glu Val Glu Val Lys Gln Gln 
            820                 825                 830         


Leu Glu Leu Ser Leu Gln Thr Leu Glu Met Glu Leu Arg Thr Val Lys 
        835                 840                 845             


Ser Asn Leu Asn Gln Val Val Gln Glu Arg Asn Asp Ala Gln Arg Gln 
    850                 855                 860                 


Leu Ser Arg Glu Gln Asn Ala Arg Met Leu Gln Asp Gly Ile Leu Thr 
865                 870                 875                 880 


Asn His Leu Ser Lys Gln Lys Glu Ile Glu Met Ala Gln Lys Lys Met 
                885                 890                 895     


Asn Ser Glu Asn Ser His Ser His Glu Glu Glu Lys Asp Leu Ser His 
            900                 905                 910         


Lys Asn Ser Met Leu Gln Glu Glu Ile Ala Met Leu Arg Leu Glu Ile 
        915                 920                 925             


Asp Thr Ile Lys Asn Gln Asn Gln Glu Lys Glu Lys Lys Cys Phe Glu 
    930                 935                 940                 


Asp Leu Lys Ile Val Lys Glu Lys Asn Glu Asp Leu Gln Lys Thr Ile 
945                 950                 955                 960 


Lys Gln Asn Glu Glu Thr Leu Thr Gln Thr Ile Ser Gln Tyr Asn Gly 
                965                 970                 975     


Arg Leu Ser Val Leu Thr Ala Glu Asn Ala Met Leu Asn Ser Lys Leu 
            980                 985                 990         


Glu Asn Glu Lys Gln Ser Lys Glu  Arg Leu Glu Ala Glu  Val Glu Ser 
        995                 1000                 1005             


Tyr His  Ser Arg Leu Ala Ala  Ala Ile His Asp Arg  Asp Gln Ser 
    1010                 1015                 1020             


Glu Thr  Ser Lys Arg Glu Leu  Glu Leu Ala Phe Gln  Arg Ala Arg 
    1025                 1030                 1035             


Asp Glu  Cys Ser Arg Leu Gln  Asp Lys Met Asn Phe  Asp Val Ser 
    1040                 1045                 1050             


Asn Leu  Lys Asp Asn Asn Glu  Ile Leu Ser Gln Gln  Leu Phe Lys 
    1055                 1060                 1065             


Thr Glu  Ser Lys Leu Asn Ser  Leu Glu Ile Glu Phe  His His Thr 
    1070                 1075                 1080             


Arg Asp  Ala Leu Arg Glu Lys  Thr Leu Gly Leu Glu  Arg Val Gln 
    1085                 1090                 1095             


Lys Asp  Leu Ser Gln Thr Gln  Cys Gln Met Lys Glu  Met Glu Gln 
    1100                 1105                 1110             


Lys Tyr  Gln Asn Glu Gln Val  Lys Val Asn Lys Tyr  Ile Gly Lys 
    1115                 1120                 1125             


Gln Glu  Ser Val Glu Glu Arg  Leu Ser Gln Leu Gln  Ser Glu Asn 
    1130                 1135                 1140             


Met Leu  Leu Arg Gln Gln Leu  Asp Asp Ala His Asn  Lys Ala Asp 
    1145                 1150                 1155             


Asn Lys  Glu Lys Thr Val Ile  Asn Ile Gln Asp Gln  Phe His Ala 
    1160                 1165                 1170             


Ile Val  Gln Lys Leu Gln Ala  Glu Ser Glu Lys Gln  Ser Leu Leu 
    1175                 1180                 1185             


Leu Glu  Glu Arg Asn Lys Glu  Leu Ile Ser Glu Cys  Asn His Leu 
    1190                 1195                 1200             


Lys Glu  Arg Gln Tyr Gln Tyr  Glu Asn Glu Lys Ala  Glu Arg Glu 
    1205                 1210                 1215             


Val Val  Val Arg Gln Leu Gln  Gln Glu Leu Ala Asp  Thr Leu Lys 
    1220                 1225                 1230             


Lys Gln  Ser Met Ser Glu Ala  Ser Leu Glu Val Thr  Ser Arg Tyr 
    1235                 1240                 1245             


Arg Ile  Asn Leu Glu Asp Glu  Thr Gln Asp Leu Lys  Lys Lys Leu 
    1250                 1255                 1260             


Gly Gln  Ile Arg Asn Gln Leu  Gln Glu Ala Gln Asp  Arg His Thr 
    1265                 1270                 1275             


Glu Ala  Val Arg Cys Ala Glu  Lys Met Gln Asp His  Lys Gln Lys 
    1280                 1285                 1290             


Leu Glu  Lys Asp Asn Ala Lys  Leu Lys Val Thr Val  Lys Lys Gln 
    1295                 1300                 1305             


Met Asp  Lys Ile Glu Glu Leu  Gln Lys Asn Leu Leu  Asn Ala Asn 
    1310                 1315                 1320             


Leu Ser  Glu Asp Glu Lys Glu  Gln Leu Lys Lys Leu  Met Glu Leu 
    1325                 1330                 1335             


Lys Gln  Ser Leu Glu Cys Asn  Leu Asp Gln Glu Met  Lys Lys Asn 
    1340                 1345                 1350             


Val Glu  Leu Glu Arg Glu Ile  Thr Gly Phe Lys Asn  Leu Leu Lys 
    1355                 1360                 1365             


Met Thr  Arg Lys Lys Leu Asn  Glu Tyr Glu Asn Gly  Glu Phe Ser 
    1370                 1375                 1380             


Phe His  Gly Asp Leu Lys Thr  Ser Gln Phe Glu Met  Asp Ile Gln 
    1385                 1390                 1395             


Ile Asn  Lys Leu Lys His Lys  Ile Asp Asp Leu Thr  Ala Glu Leu 
    1400                 1405                 1410             


Glu Thr  Ala Gly Ser Lys Cys  Leu His Leu Asp Thr  Lys Asn Gln 
    1415                 1420                 1425             


Ile Leu  Gln Glu Glu Leu Leu  Ser Met Lys Thr Val  Gln Lys Lys 
    1430                 1435                 1440             


Cys Glu  Lys Leu Gln Lys Asn  Lys Lys Lys Leu Glu  Gln Glu Val 
    1445                 1450                 1455             


Ile Asn  Leu Arg Ser His Ile  Glu Arg Asn Met Val  Glu Leu Gly 
    1460                 1465                 1470             


Gln Val  Lys Gln Tyr Lys Gln  Glu Ile Glu Glu Arg  Ala Arg Gln 
    1475                 1480                 1485             


Glu Ile  Ala Glu Lys Leu Lys  Glu Val Asn Leu Phe  Leu Gln Ala 
    1490                 1495                 1500             


Gln Ala  Ala Ser Gln Glu Asn  Leu Glu Gln Phe Arg  Glu Asn Asn 
    1505                 1510                 1515             


Phe Ala  Ser Met Lys Ser Gln  Met Glu Leu Arg Ile  Lys Asp Leu 
    1520                 1525                 1530             


Glu Ser  Glu Leu Ser Lys Ile  Lys Thr Ser Gln Glu  Asp Phe Asn 
    1535                 1540                 1545             


Lys Thr  Glu Leu Glu Lys Tyr  Lys Gln Leu Tyr Leu  Glu Glu Leu 
    1550                 1555                 1560             


Lys Val  Arg Lys Ser Leu Ser  Ser Lys Leu Thr Lys  Thr Asn Glu 
    1565                 1570                 1575             


Arg Leu  Ala Glu Val Asn Thr  Lys Leu Leu Val Glu  Lys Gln Gln 
    1580                 1585                 1590             


Ser Arg  Ser Leu Phe Thr Thr  Leu Thr Thr Arg Pro  Val Met Glu 
    1595                 1600                 1605             


Pro Pro  Cys Val Gly Asn Leu  Asn Asn Ser Leu Asp  Leu Asn Arg 
    1610                 1615                 1620             


Lys Leu  Ile Pro Arg Glu Asn  Leu Val Ile Ser Thr  Ser Asn Pro 
    1625                 1630                 1635             


Arg Ala  Ser Asn Asn Ser Met  Glu Asn Tyr Leu Ser  Lys Met Gln 
    1640                 1645                 1650             


Gln Glu  Leu Glu Lys Asn Ile  Thr Arg Glu Leu Lys  Glu Ala Ala 
    1655                 1660                 1665             


Ala Glu  Leu Glu Ser Gly Ser  Ile Ala Ser Pro Leu  Gly Ser Thr 
    1670                 1675                 1680             


Asp Glu  Ser Asn Leu Asn Gln  Asp Leu Val Trp Lys  Ala Ser Arg 
    1685                 1690                 1695             


Glu Tyr  Val Gln Val Leu Lys  Lys Asn Tyr Met Ile  
    1700                 1705                 1710 


<210>  542
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD28__Homo_sapiens__NP_056014

<400>  542

Met Ala Phe Leu Lys Leu Arg Asp Gln Pro Ser Leu Val Gln Ala Ile 
1               5                   10                  15      


Phe Asn Gly Asp Pro Asp Glu Val Arg Ala Leu Ile Phe Lys Lys Glu 
            20                  25                  30          


Asp Val Asn Phe Gln Asp Asn Glu Lys Arg Thr Pro Leu His Ala Ala 
        35                  40                  45              


Ala Tyr Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly 
    50                  55                  60                  


Ala Arg Val Asn Ala Lys Asp Ser Lys Trp Leu Thr Pro Leu His Arg 
65                  70                  75                  80  


Ala Val Ala Ser Cys Ser Glu Glu Ala Val Gln Val Leu Leu Lys His 
                85                  90                  95      


Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His 
            100                 105                 110         


Ile Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Ala Leu Val Pro 
        115                 120                 125             


Leu Leu Ser Asn Val Asn Val Ser Asp Arg Ala Gly Arg Thr Ala Leu 
    130                 135                 140                 


His His Ala Ala Phe Ser Gly His Gly Glu Met Val Lys Leu Leu Leu 
145                 150                 155                 160 


Ser Arg Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala 
                165                 170                 175     


Ile His Trp Ala Ala Tyr Met Gly His Ile Glu Val Val Lys Leu Leu 
            180                 185                 190         


Val Ser His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Ser Tyr Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Ser Ser Gly Met Ile Ser Val Val Lys Tyr 
    210                 215                 220                 


Leu Leu Asp Leu Gly Val Asp Met Asn Glu Pro Asn Ala Tyr Gly Asn 
225                 230                 235                 240 


Thr Pro Leu His Val Ala Cys Tyr Asn Gly Gln Asp Val Val Val Asn 
                245                 250                 255     


Glu Leu Ile Asp Cys Gly Ala Ile Val Asn Gln Lys Asn Glu Lys Gly 
            260                 265                 270         


Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys 
        275                 280                 285             


Leu Glu Leu Leu Val Gly Asn Gly Ala Asp Val Asn Met Lys Ser Lys 
    290                 295                 300                 


Asp Gly Lys Thr Pro Leu His Met Thr Ala Leu His Gly Arg Phe Ser 
305                 310                 315                 320 


Arg Ser Gln Thr Ile Ile Gln Ser Gly Ala Val Ile Asp Cys Glu Asp 
                325                 330                 335     


Lys Asn Gly Asn Thr Pro Leu His Ile Ala Ala Arg Tyr Gly His Glu 
            340                 345                 350         


Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Arg 
        355                 360                 365             


Gly Ile His Gly Met Phe Pro Leu His Leu Ala Ala Leu Ser Gly Phe 
    370                 375                 380                 


Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Asp Ile Asp Thr 
385                 390                 395                 400 


Pro Asp Asp Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly 
                405                 410                 415     


Asn Leu Glu Cys Leu Asn Leu Leu Leu Asn Thr Gly Ala Asp Phe Asn 
            420                 425                 430         


Lys Lys Asp Lys Phe Gly Arg Ser Pro Leu His Tyr Ala Ala Ala Asn 
        435                 440                 445             


Cys Asn Tyr Gln Cys Leu Phe Ala Leu Val Gly Ser Gly Ala Ser Val 
    450                 455                 460                 


Asn Asp Leu Asp Glu Arg Gly Cys Thr Pro Leu His Tyr Ala Ala Thr 
465                 470                 475                 480 


Ser Asp Thr Asp Gly Lys Cys Leu Glu Tyr Leu Leu Arg Asn Asp Ala 
                485                 490                 495     


Asn Pro Gly Ile Arg Asp Lys Gln Gly Tyr Asn Ala Val His Tyr Ser 
            500                 505                 510         


Ala Ala Tyr Gly His Arg Leu Cys Leu Gln Leu Ile Ala Ser Glu Thr 
        515                 520                 525             


Pro Leu Asp Val Leu Met Glu Thr Ser Gly Thr Asp Met Leu Ser Asp 
    530                 535                 540                 


Ser Asp Asn Arg Ala Thr Ile Ser Pro Leu His Leu Ala Ala Tyr His 
545                 550                 555                 560 


Gly His His Gln Ala Leu Glu Val Leu Val Gln Ser Leu Leu Asp Leu 
                565                 570                 575     


Asp Val Arg Asn Ser Ser Gly Arg Thr Pro Leu Asp Leu Ala Ala Phe 
            580                 585                 590         


Lys Gly His Val Glu Cys Val Asp Val Leu Ile Asn Gln Gly Ala Ser 
        595                 600                 605             


Ile Leu Val Lys Asp Tyr Ile Leu Lys Arg Thr Pro Ile His Ala Ala 
    610                 615                 620                 


Ala Thr Asn Gly His Ser Glu Cys Leu Arg Leu Leu Ile Gly Asn Ala 
625                 630                 635                 640 


Glu Pro Gln Asn Ala Val Asp Ile Gln Asp Gly Asn Gly Gln Thr Pro 
                645                 650                 655     


Leu Met Leu Ser Val Leu Asn Gly His Thr Asp Cys Val Tyr Ser Leu 
            660                 665                 670         


Leu Asn Lys Gly Ala Asn Val Asp Ala Lys Asp Lys Trp Gly Arg Thr 
        675                 680                 685             


Ala Leu His Arg Gly Ala Val Thr Gly His Glu Glu Cys Val Asp Ala 
    690                 695                 700                 


Leu Leu Gln His Gly Ala Lys Cys Leu Leu Arg Asp Ser Arg Gly Arg 
705                 710                 715                 720 


Thr Pro Ile His Leu Ser Ala Ala Cys Gly His Ile Gly Val Leu Gly 
                725                 730                 735     


Ala Leu Leu Gln Ser Ala Ala Ser Met Asp Ala Asn Pro Ala Thr Ala 
            740                 745                 750         


Asp Asn His Gly Tyr Thr Ala Leu His Trp Ala Cys Tyr Asn Gly His 
        755                 760                 765             


Glu Thr Cys Val Glu Leu Leu Leu Glu Gln Glu Val Phe Gln Lys Thr 
    770                 775                 780                 


Glu Gly Asn Ala Phe Ser Pro Leu His Cys Ala Val Ile Asn Asp Asn 
785                 790                 795                 800 


Glu Gly Ala Ala Glu Met Leu Ile Asp Thr Leu Gly Ala Ser Ile Val 
                805                 810                 815     


Asn Ala Thr Asp Ser Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe 
            820                 825                 830         


Thr Asp His Val Glu Cys Leu Gln Leu Leu Leu Ser His Asn Ala Gln 
        835                 840                 845             


Val Asn Ser Val Asp Ser Thr Gly Lys Thr Pro Leu Met Met Ala Ala 
    850                 855                 860                 


Glu Asn Gly Gln Thr Asn Thr Val Glu Met Leu Val Ser Ser Ala Ser 
865                 870                 875                 880 


Ala Glu Leu Thr Leu Gln Asp Asn Ser Lys Asn Thr Ala Leu His Leu 
                885                 890                 895     


Ala Cys Ser Lys Gly His Glu Thr Ser Ala Leu Leu Ile Leu Glu Lys 
            900                 905                 910         


Ile Thr Asp Arg Asn Leu Ile Asn Ala Thr Asn Ala Ala Leu Gln Thr 
        915                 920                 925             


Pro Leu His Val Ala Ala Arg Asn Gly Leu Thr Met Val Val Gln Glu 
    930                 935                 940                 


Leu Leu Gly Lys Gly Ala Ser Val Leu Ala Val Asp Glu Asn Gly Tyr 
945                 950                 955                 960 


Thr Pro Ala Leu Ala Cys Ala Pro Asn Lys Asp Val Ala Asp Cys Leu 
                965                 970                 975     


Ala Leu Ile Leu Ala Thr Met Met Pro Val Ser Ser Ser Ser Pro Leu 
            980                 985                 990         


Ser Ser Leu Thr Phe Asn Ala Ile  Asn Arg Tyr Thr Asn  Thr Ser Lys 
        995                 1000                 1005             


Thr Val  Ser Phe Glu Ala Leu  Pro Ile Met Arg Asn  Glu Pro Ser 
    1010                 1015                 1020             


Ser Tyr  Cys Ser Phe Asn Asn  Ile Gly Gly Glu Gln  Glu Tyr Leu 
    1025                 1030                 1035             


Tyr Thr  Asp Val Asp Glu Leu  Asn Asp Ser Asp Ser  Glu Thr Tyr 
    1040                 1045                 1050             


<210>  543
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD2__Homo_sapiens__NP_001123453

<400>  543

Met Ala Lys Ala Pro Ser Trp Ala Gly Val Gly Ala Leu Ala Tyr Lys 
1               5                   10                  15      


Ala Pro Glu Ala Leu Trp Pro Ala Glu Ala Val Met Asp Gly Thr Met 
            20                  25                  30          


Glu Asp Ser Glu Ala Val Gln Arg Ala Thr Ala Leu Ile Glu Gln Arg 
        35                  40                  45              


Leu Ala Gln Glu Glu Glu Asn Glu Lys Leu Arg Gly Asp Ala Arg Gln 
    50                  55                  60                  


Lys Leu Pro Met Asp Leu Leu Val Leu Glu Asp Glu Lys His His Gly 
65                  70                  75                  80  


Ala Gln Ser Ala Ala Leu Gln Lys Val Lys Gly Gln Glu Arg Val Arg 
                85                  90                  95      


Lys Thr Ser Leu Asp Leu Arg Arg Glu Ile Ile Asp Val Gly Gly Ile 
            100                 105                 110         


Gln Asn Leu Ile Glu Leu Arg Lys Lys Arg Lys Gln Lys Lys Arg Asp 
        115                 120                 125             


Ala Leu Ala Ala Ser His Glu Pro Pro Pro Glu Pro Glu Glu Ile Thr 
    130                 135                 140                 


Gly Pro Val Asp Glu Glu Thr Phe Leu Lys Ala Ala Val Glu Gly Lys 
145                 150                 155                 160 


Met Lys Val Ile Glu Lys Phe Leu Ala Asp Gly Gly Ser Ala Asp Thr 
                165                 170                 175     


Cys Asp Gln Phe Arg Arg Thr Ala Leu His Arg Ala Ser Leu Glu Gly 
            180                 185                 190         


His Met Glu Ile Leu Glu Lys Leu Leu Asp Asn Gly Ala Thr Val Asp 
        195                 200                 205             


Phe Gln Asp Arg Leu Asp Cys Thr Ala Met His Trp Ala Cys Arg Gly 
    210                 215                 220                 


Gly His Leu Glu Val Val Lys Leu Leu Gln Ser His Gly Ala Asp Thr 
225                 230                 235                 240 


Asn Val Arg Asp Lys Glu Gly Asp Thr Ala Leu His Asp Ala Val Arg 
                245                 250                 255     


Leu Asn Arg Tyr Lys Ile Ile Lys Leu Leu Leu Leu His Gly Ala Asp 
            260                 265                 270         


Met Met Thr Lys Asn Leu Ala Gly Lys Thr Pro Thr Asp Leu Val Gln 
        275                 280                 285             


Leu Trp Gln Ala Asp Thr Arg His Ala Leu Glu His Pro Glu Pro Gly 
    290                 295                 300                 


Ala Glu His Asn Gly Leu Glu Gly Pro Asn Asp Ser Gly Arg Glu Thr 
305                 310                 315                 320 


Pro Gln Pro Val Pro Ala Gln 
                325         


<210>  544
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD30A__Homo_sapiens__NP_443723

<400>  544

Met Thr Lys Arg Lys Lys Thr Ile Asn Leu Asn Ile Gln Asp Ala Gln 
1               5                   10                  15      


Lys Arg Thr Ala Leu His Trp Ala Cys Val Asn Gly His Glu Glu Val 
            20                  25                  30          


Val Thr Phe Leu Val Asp Arg Lys Cys Gln Leu Asp Val Leu Asp Gly 
        35                  40                  45              


Glu His Arg Thr Pro Leu Met Lys Ala Leu Gln Cys His Gln Glu Ala 
    50                  55                  60                  


Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Ile Asn Leu Val Asp 
65                  70                  75                  80  


Val Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Ser Glu Ile Leu 
                85                  90                  95      


Ser Val Val Ala Lys Leu Leu Ser His Gly Ala Val Ile Glu Val His 
            100                 105                 110         


Asn Lys Ala Ser Leu Thr Pro Leu Leu Leu Ser Ile Thr Lys Arg Ser 
        115                 120                 125             


Glu Gln Ile Val Glu Phe Leu Leu Ile Lys Asn Ala Asn Ala Asn Ala 
    130                 135                 140                 


Val Asn Lys Tyr Lys Cys Thr Ala Leu Met Leu Ala Val Cys His Gly 
145                 150                 155                 160 


Ser Ser Glu Ile Val Gly Met Leu Leu Gln Gln Asn Val Asp Val Phe 
                165                 170                 175     


Ala Ala Asp Ile Cys Gly Val Thr Ala Glu His Tyr Ala Val Thr Cys 
            180                 185                 190         


Gly Phe His His Ile His Glu Gln Ile Met Glu Tyr Ile Arg Lys Leu 
        195                 200                 205             


Ser Lys Asn His Gln Asn Thr Asn Pro Glu Gly Thr Ser Ala Gly Thr 
    210                 215                 220                 


Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala Glu 
225                 230                 235                 240 


Ser Leu Val Glu Lys Thr Pro Asp Glu Ala Ala Pro Leu Val Glu Arg 
                245                 250                 255     


Thr Pro Asp Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp Glu Ala 
            260                 265                 270         


Ala Ser Leu Val Glu Gly Thr Ser Asp Lys Ile Gln Cys Leu Glu Lys 
        275                 280                 285             


Ala Thr Ser Gly Lys Phe Glu Gln Ser Ala Glu Glu Thr Pro Arg Glu 
    290                 295                 300                 


Ile Thr Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp Pro Ala 
305                 310                 315                 320 


Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Asp Thr Pro 
                325                 330                 335     


Arg Glu Ile Met Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp 
            340                 345                 350         


Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Thr 
        355                 360                 365             


Pro Val Lys Thr Gly Cys Val Ala Arg Val Thr Ser Asn Lys Thr Lys 
    370                 375                 380                 


Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala Cys Pro Thr Lys Glu 
385                 390                 395                 400 


Ser Ser Thr Lys Ala Ser Ala Asn Asp Gln Arg Phe Pro Ser Glu Ser 
                405                 410                 415     


Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp Ser Arg Ser Leu Phe 
            420                 425                 430         


Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro Glu Ser Ile Tyr Gln 
        435                 440                 445             


Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Pro Pro Lys Lys Pro 
    450                 455                 460                 


Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn Ser Val Pro Asn Lys 
465                 470                 475                 480 


Ala Phe Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Pro Met Phe 
                485                 490                 495     


Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Ser 
            500                 505                 510         


Glu Ser Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys 
        515                 520                 525             


Ala Thr His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu 
    530                 535                 540                 


Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Thr Cys Gly Met Lys Val 
545                 550                 555                 560 


Ser Ile Pro Thr Lys Ala Leu Glu Leu Lys Asp Met Gln Thr Phe Lys 
                565                 570                 575     


Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu Pro Ala Thr Glu Met 
            580                 585                 590         


Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr 
        595                 600                 605             


Leu Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr 
    610                 615                 620                 


Glu Glu Asn Ser Trp Asp Thr Glu Ser Leu Cys Glu Thr Val Ser Gln 
625                 630                 635                 640 


Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln Lys Glu Ile Asp Lys 
                645                 650                 655     


Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys Asp Gly Leu Leu Lys 
            660                 665                 670         


Ala Asn Cys Gly Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu 
        675                 680                 685             


Met Asp Met Gln Thr Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala 
    690                 695                 700                 


Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu 
705                 710                 715                 720 


Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Glu Ile Leu Pro Ser 
                725                 730                 735     


Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser Trp Asp Ser Glu Ser 
            740                 745                 750         


Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Thr 
        755                 760                 765             


His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro 
    770                 775                 780                 


Asp Asn Asp Gly Phe Leu Lys Ala Pro Cys Arg Met Lys Val Ser Ile 
785                 790                 795                 800 


Pro Thr Lys Ala Leu Glu Leu Met Asp Met Gln Thr Phe Lys Ala Glu 
                805                 810                 815     


Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys 
            820                 825                 830         


Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr Leu Arg 
        835                 840                 845             


Ala Asp Gln Met Phe Pro Ser Glu Ser Lys Gln Lys Lys Val Glu Glu 
    850                 855                 860                 


Asn Ser Trp Asp Ser Glu Ser Leu Arg Glu Thr Val Ser Gln Lys Asp 
865                 870                 875                 880 


Val Cys Val Pro Lys Ala Thr His Gln Lys Glu Met Asp Lys Ile Ser 
                885                 890                 895     


Gly Lys Leu Glu Asp Ser Thr Ser Leu Ser Lys Ile Leu Asp Thr Val 
            900                 905                 910         


His Ser Cys Glu Arg Ala Arg Glu Leu Gln Lys Asp His Cys Glu Gln 
        915                 920                 925             


Arg Thr Gly Lys Met Glu Gln Met Lys Lys Lys Phe Cys Val Leu Lys 
    930                 935                 940                 


Lys Lys Leu Ser Glu Ala Lys Glu Ile Lys Ser Gln Leu Glu Asn Gln 
945                 950                 955                 960 


Lys Val Lys Trp Glu Gln Glu Leu Cys Ser Val Arg Leu Thr Leu Asn 
                965                 970                 975     


Gln Glu Glu Glu Lys Arg Arg Asn Ala Asp Ile Leu Asn Glu Lys Ile 
            980                 985                 990         


Arg Glu Glu Leu Gly Arg Ile Glu  Glu Gln His Arg Lys  Glu Leu Glu 
        995                 1000                 1005             


Val Lys  Gln Gln Leu Glu Gln  Ala Leu Arg Ile Gln  Asp Ile Glu 
    1010                 1015                 1020             


Leu Lys  Ser Val Glu Ser Asn  Leu Asn Gln Val Ser  His Thr His 
    1025                 1030                 1035             


Glu Asn  Glu Asn Tyr Leu Leu  His Glu Asn Cys Met  Leu Lys Lys 
    1040                 1045                 1050             


Glu Ile  Ala Met Leu Lys Leu  Glu Ile Ala Thr Leu  Lys His Gln 
    1055                 1060                 1065             


Tyr Gln  Glu Lys Glu Asn Lys  Tyr Phe Glu Asp Ile  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Lys Asn Ala Glu Leu  Gln Met Thr Leu Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Ser  Leu Thr Lys Arg Ala  Ser Gln Tyr Ser Gly  Gln Leu Lys 
    1100                 1105                 1110             


Val Leu  Ile Ala Glu Asn Thr  Met Leu Thr Ser Lys  Leu Lys Glu 
    1115                 1120                 1125             


Lys Gln  Asp Lys Glu Ile Leu  Glu Ala Glu Ile Glu  Ser His His 
    1130                 1135                 1140             


Pro Arg  Leu Ala Ser Ala Val  Gln Asp His Asp Gln  Ile Val Thr 
    1145                 1150                 1155             


Ser Arg  Lys Ser Gln Glu Pro  Ala Phe His Ile Ala  Gly Asp Ala 
    1160                 1165                 1170             


Cys Leu  Gln Arg Lys Met Asn  Val Asp Val Ser Ser  Thr Ile Tyr 
    1175                 1180                 1185             


Asn Asn  Glu Val Leu His Gln  Pro Leu Ser Glu Ala  Gln Arg Lys 
    1190                 1195                 1200             


Ser Lys  Ser Leu Lys Ile Asn  Leu Asn Tyr Ala Gly  Asp Ala Leu 
    1205                 1210                 1215             


Arg Glu  Asn Thr Leu Val Ser  Glu His Ala Gln Arg  Asp Gln Arg 
    1220                 1225                 1230             


Glu Thr  Gln Cys Gln Met Lys  Glu Ala Glu His Met  Tyr Gln Asn 
    1235                 1240                 1245             


Glu Gln  Asp Asn Val Asn Lys  His Thr Glu Gln Gln  Glu Ser Leu 
    1250                 1255                 1260             


Asp Gln  Lys Leu Phe Gln Leu  Gln Ser Lys Asn Met  Trp Leu Gln 
    1265                 1270                 1275             


Gln Gln  Leu Val His Ala His  Lys Lys Ala Asp Asn  Lys Ser Lys 
    1280                 1285                 1290             


Ile Thr  Ile Asp Ile His Phe  Leu Glu Arg Lys Met  Gln His His 
    1295                 1300                 1305             


Leu Leu  Lys Glu Lys Asn Glu  Glu Ile Phe Asn Tyr  Asn Asn His 
    1310                 1315                 1320             


Leu Lys  Asn Arg Ile Tyr Gln  Tyr Glu Lys Glu Lys  Ala Glu Thr 
    1325                 1330                 1335             


Glu Asn  Ser 
    1340     


<210>  545
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD36B__Homo_sapiens__NP_079466

<400>  545

Met Glu Arg Leu Cys Ser Asp Gly Phe Ala Phe Pro His Tyr Tyr Ile 
1               5                   10                  15      


Lys Pro Tyr His Leu Lys Arg Ile His Arg Ala Val Leu Arg Gly Asn 
            20                  25                  30          


Leu Glu Lys Leu Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys 
        35                  40                  45              


Arg Asp Arg Lys Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly 
    50                  55                  60                  


Gln Pro Glu Met Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn 
65                  70                  75                  80  


Leu Cys Asp Arg Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu 
                85                  90                  95      


Arg Gln Glu Ala Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asp Pro 
            100                 105                 110         


Asn Ile Thr Asp Val Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr 
        115                 120                 125             


Asn Glu Asp Thr Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn 
    130                 135                 140                 


Ile Glu Glu Cys Ser Lys Asn Glu Tyr Gln Pro Leu Leu Leu Ala Val 
145                 150                 155                 160 


Ser Arg Arg Lys Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala 
                165                 170                 175     


Asn Val Asn Ala Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile Leu Ala 
            180                 185                 190         


Val Thr Leu Gly Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn 
        195                 200                 205             


Ile Asp Val Phe Ser Arg Asp Val Tyr Gly Lys Leu Ala Glu Asp Tyr 
    210                 215                 220                 


Ala Ser Glu Ala Glu Asn Arg Val Ile Phe Asp Leu Ile Tyr Glu Tyr 
225                 230                 235                 240 


Lys Arg Lys Arg Tyr Glu Asp Leu Pro Ile Asn Ser Asn Pro Val Ser 
                245                 250                 255     


Pro Gln Lys Gln Arg Ala Glu Lys Ala Thr Ser Asp Asp Lys Asp Ser 
            260                 265                 270         


Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly Pro Ile Ser Gly Thr 
        275                 280                 285             


Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser Asp Glu Lys 
    290                 295                 300                 


Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly Gln Gln Ser 
305                 310                 315                 320 


Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Gln Lys Val Ile Phe Lys 
                325                 330                 335     


Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Met Gly Gly Gly 
            340                 345                 350         


Lys Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Ser Lys Thr Ala 
        355                 360                 365             


Ser Asp Lys Thr Asp Ser Ala Leu Asn Thr Ala Thr Glu Ile Lys Asp 
    370                 375                 380                 


Gly Leu Gln Cys Gly Thr Val Ser Ser Gln Lys Gln Gln Ala Leu Lys 
385                 390                 395                 400 


Ala Thr Thr Asp Glu Glu Gly Ser Val Ser Asn Ile Ala Thr Glu Ile 
                405                 410                 415     


Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln Lys Lys Pro Ala 
            420                 425                 430         


Leu Lys Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser Asn Ile Thr Arg 
        435                 440                 445             


Glu Lys Lys Asp Gly Glu Ile Ser Arg Thr Val Ser Ser Gln Lys Pro 
    450                 455                 460                 


Pro Ala Leu Lys Ala Thr Ser Val Lys Glu Asp Ser Val Leu Asn Ile 
465                 470                 475                 480 


Ala Arg Glu Lys Lys Asp Gly Glu Lys Ser Arg Thr Val Ser Phe Glu 
                485                 490                 495     


Gln Pro Pro Gly Leu Lys Ala Thr Arg Asp Glu Lys Asp Ser Leu Leu 
            500                 505                 510         


Asn Ile Ala Arg Gly Lys Lys Asp Gly Glu Lys Thr Arg Arg Val Ser 
        515                 520                 525             


Ser His Lys Gln Pro Ser Leu Lys Ala Thr Ser Asp Lys Glu Asp Ser 
    530                 535                 540                 


Val Pro Asn Met Ala Thr Glu Thr Lys Asp Glu Gln Ile Ser Gly Thr 
545                 550                 555                 560 


Val Ser Cys Gln Lys Gln Pro Ala Leu Lys Ala Thr Ser Asp Lys Lys 
                565                 570                 575     


Asp Ser Val Ser Asn Ile Pro Thr Glu Ile Lys Asp Gly Gln Gln Ser 
            580                 585                 590         


Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Trp Lys Ala Thr Ser Val 
        595                 600                 605             


Lys Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Asp Gly Gln 
    610                 615                 620                 


Ile Arg Gly Thr Val Ser Ser Gln Arg Arg Pro Ala Leu Lys Thr Thr 
625                 630                 635                 640 


Gly Asp Glu Lys Asp Ser Val Ser Asn Ile Ala Arg Glu Ile Lys Asp 
                645                 650                 655     


Gly Glu Lys Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Gln Lys 
            660                 665                 670         


Val Ile Phe Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile 
        675                 680                 685             


Thr Gly Gly Gly Lys Ser Gly Thr Glu Tyr Pro Glu Asn Leu Arg Thr 
    690                 695                 700                 


Leu Lys Ala Thr Ile Glu Asn Lys Asp Ser Val Leu Asn Thr Ala Thr 
705                 710                 715                 720 


Lys Met Lys Glu Val Gln Thr Ser Thr Pro Ala Glu Gln Asp Leu Glu 
                725                 730                 735     


Met Ala Ser Glu Gly Glu Gln Lys Arg Leu Glu Glu Tyr Glu Asn Asn 
            740                 745                 750         


Gln Pro Gln Val Lys Asn Gln Ile His Ser Arg Asp Asp Leu Asp Asp 
        755                 760                 765             


Ile Ile Gln Ser Ser Gln Thr Val Ser Glu Asp Gly Asp Ser Leu Cys 
    770                 775                 780                 


Cys Asn Cys Lys Asn Val Ile Leu Leu Ile Asp Gln His Glu Met Lys 
785                 790                 795                 800 


Cys Lys Asp Cys Val His Leu Leu Lys Ile Lys Asn Thr Phe Cys Leu 
                805                 810                 815     


Trp Lys Arg Leu Ile Lys Leu Lys Asp Asn His Cys Glu Gln Leu Arg 
            820                 825                 830         


Val Lys Ile Arg Lys Leu Lys Asn Lys Ala Ser Val Leu Gln Lys Arg 
        835                 840                 845             


Ile Ser Glu Lys Glu Glu Ile Lys Ser Gln Leu Lys His Glu Ile Leu 
    850                 855                 860                 


Glu Leu Glu Lys Glu Leu Cys Ser Leu Arg Phe Ala Ile Gln Gln Glu 
865                 870                 875                 880 


Lys Lys Lys Arg Arg Asn Val Glu Glu Leu His Gln Lys Val Arg Glu 
                885                 890                 895     


Lys Leu Arg Ile Thr Glu Glu Gln Tyr Arg Ile Glu Ala Asp Val Thr 
            900                 905                 910         


Lys Pro Ile Lys Pro Ala Leu Lys Ser Ala Glu Val Glu Leu Lys Thr 
        915                 920                 925             


Gly Gly Asn Asn Ser Asn Gln Val Ser Glu Thr Asp Glu Lys Glu Asp 
    930                 935                 940                 


Leu Leu His Glu Asn Arg Leu Met Gln Asp Glu Ile Ala Arg Leu Arg 
945                 950                 955                 960 


Leu Glu Lys Asp Thr Ile Lys Asn Gln Asn Leu Glu Lys Lys Tyr Leu 
                965                 970                 975     


Lys Asp Phe Glu Ile Val Lys Arg Lys His Glu Asp Leu Gln Lys Ala 
            980                 985                 990         


Leu Lys Arg Asn Gly Glu Thr Leu  Ala Lys Thr Ile Ala  Cys Tyr Ser 
        995                 1000                 1005             


Gly Gln  Leu Ala Ala Leu Thr  Asp Glu Asn Thr Thr  Leu Arg Ser 
    1010                 1015                 1020             


Lys Leu  Glu Lys Gln Arg Glu  Ser Arg Gln Arg Leu  Glu Thr Glu 
    1025                 1030                 1035             


Met Gln  Ser Tyr Arg Cys Arg  Leu Asn Ala Ala Arg  Cys Asp His 
    1040                 1045                 1050             


Asp Gln  Ser His Ser Ser Lys  Arg Asp Gln Glu Leu  Ala Phe Gln 
    1055                 1060                 1065             


Gly Thr  Val Asp Lys Cys Arg  His Leu Gln Glu Asn  Leu Asn Ser 
    1070                 1075                 1080             


His Val  Leu Ile Leu Ser Leu  Gln Leu Ser Lys Ala  Glu Ser Lys 
    1085                 1090                 1095             


Ser Arg  Val Leu Lys Thr Glu  Leu His Tyr Thr Gly  Glu Ala Leu 
    1100                 1105                 1110             


Lys Glu  Lys Ala Leu Val Phe  Glu His Val Gln Ser  Glu Leu Lys 
    1115                 1120                 1125             


Gln Lys  Gln Ser Gln Met Lys  Asp Ile Glu Lys Met  Tyr Lys Ser 
    1130                 1135                 1140             


Gly Tyr  Asn Thr Met Glu Lys  Cys Ile Glu Lys Gln  Glu Arg Phe 
    1145                 1150                 1155             


Cys Gln  Leu Lys Lys Gln Asn  Met Leu Leu Gln Gln  Gln Leu Asp 
    1160                 1165                 1170             


Asp Ala  Arg Asn Lys Ala Asp  Asn Gln Glu Lys Ala  Ile Leu Asn 
    1175                 1180                 1185             


Ile Gln  Ala Arg Cys Asp Ala  Arg Val Gln Asn Leu  Gln Ala Glu 
    1190                 1195                 1200             


Cys Arg  Lys His Arg Leu Leu  Leu Glu Glu Asp Asn  Lys Met Leu 
    1205                 1210                 1215             


Val Asn  Glu Leu Asn His Ser  Lys Glu Lys Glu Cys  Gln Tyr Glu 
    1220                 1225                 1230             


Lys Glu  Lys Ala Glu Arg Glu  Val Ala Val Arg Gln  Leu Gln Gln 
    1235                 1240                 1245             


Lys Arg  Asp Asp Val Leu Asn  Lys Gly Ser Ala Thr  Lys Ala Leu 
    1250                 1255                 1260             


Leu Asp  Ala Ser Ser Arg His  Cys Thr Tyr Leu Glu  Asn Gly Met 
    1265                 1270                 1275             


Gln Asp  Ser Arg Lys Lys Leu  Asp Gln Met Arg Ser  Gln Phe Gln 
    1280                 1285                 1290             


Glu Ile  Gln Asp Gln Leu Thr  Ala Thr Ile Arg Cys  Thr Lys Glu 
    1295                 1300                 1305             


Met Glu  Gly Asp Thr Gln Lys  Leu Glu Val Glu His  Val Met Met 
    1310                 1315                 1320             


Arg Lys  Ile Ile Lys Lys Gln  Asp Asp Gln Ile Glu  Arg Leu Glu 
    1325                 1330                 1335             


Lys Ile  Leu Gln His Ser Ser  Leu Met Leu Gln Val  Phe Glu Ser 
    1340                 1345                 1350             


<210>  546
<211>  1941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD36__Homo_sapiens__NP_001157787

<400>  546

Met Glu Asp Gly Lys Arg Glu Arg Trp Pro Thr Leu Met Glu Arg Leu 
1               5                   10                  15      


Cys Ser Asp Gly Phe Ala Phe Pro Gln Tyr Pro Ile Lys Pro Tyr His 
            20                  25                  30          


Leu Lys Arg Ile His Arg Ala Val Leu His Gly Asn Leu Glu Lys Leu 
        35                  40                  45              


Lys Tyr Leu Leu Leu Thr Tyr Tyr Asp Ala Asn Lys Arg Asp Arg Lys 
    50                  55                  60                  


Glu Arg Thr Ala Leu His Leu Ala Cys Ala Thr Gly Gln Pro Glu Met 
65                  70                  75                  80  


Val His Leu Leu Val Ser Arg Arg Cys Glu Leu Asn Leu Cys Asp Arg 
                85                  90                  95      


Glu Asp Arg Thr Pro Leu Ile Lys Ala Val Gln Leu Arg Gln Glu Ala 
            100                 105                 110         


Cys Ala Thr Leu Leu Leu Gln Asn Gly Ala Asn Pro Asn Ile Thr Asp 
        115                 120                 125             


Phe Phe Gly Arg Thr Ala Leu His Tyr Ala Val Tyr Asn Glu Asp Thr 
    130                 135                 140                 


Ser Met Ile Glu Lys Leu Leu Ser His Gly Thr Asn Ile Glu Glu Cys 
145                 150                 155                 160 


Ser Lys Cys Glu Tyr Gln Pro Leu Leu Phe Ala Val Ser Arg Arg Lys 
                165                 170                 175     


Val Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Asn Val Asn Ala 
            180                 185                 190         


Ile Asp Tyr Leu Gly Arg Ser Ala Leu Ile His Ala Val Thr Leu Gly 
        195                 200                 205             


Glu Lys Asp Ile Val Ile Leu Leu Leu Gln His Asn Ile Asp Val Leu 
    210                 215                 220                 


Ser Arg Asp Ala Phe Arg Lys Ile Ala Gly Asp Tyr Ala Ile Glu Ala 
225                 230                 235                 240 


Lys Asn Arg Val Ile Phe Asp Leu Ile Tyr Glu Tyr Glu Arg Lys Arg 
                245                 250                 255     


Tyr Glu Asp Leu Pro Ile Asn Ser Asn Pro Val Ser Ser Gln Lys Gln 
            260                 265                 270         


Pro Ala Leu Lys Ala Thr Ser Gly Lys Glu Asp Ser Ile Ser Asn Ile 
        275                 280                 285             


Ala Thr Glu Ile Lys Asp Gly Gln Lys Ser Gly Thr Val Ser Ser Gln 
    290                 295                 300                 


Lys Gln Pro Ala Leu Lys Asp Thr Ser Asp Lys Asp Asp Ser Val Ser 
305                 310                 315                 320 


Asn Thr Ala Thr Glu Ile Lys Asp Glu Gln Lys Ser Gly Thr Val Leu 
                325                 330                 335     


Pro Ala Val Glu Gln Cys Leu Asn Arg Ser Leu Tyr Arg Pro Asp Ala 
            340                 345                 350         


Val Ala Gln Pro Val Thr Glu Asn Glu Phe Ser Leu Glu Ser Glu Ile 
        355                 360                 365             


Ile Ser Lys Leu Tyr Ile Pro Lys Arg Lys Ile Ile Ser Pro Arg Ser 
    370                 375                 380                 


Ile Lys Asp Val Leu Pro Pro Val Glu Glu Ala Val Asp Arg Cys Leu 
385                 390                 395                 400 


Tyr Leu Leu Asp Arg Phe Ala Gln Pro Val Thr Lys Asp Lys Phe Ala 
                405                 410                 415     


Leu Glu Ser Glu Asn Ile Ser Glu Pro Tyr Phe Thr Asn Arg Arg Thr 
            420                 425                 430         


Ile Ser Gln Gln Ser Ala Glu Asn Leu Asp Ala Ala Cys Gly Ile Asp 
        435                 440                 445             


Lys Thr Glu Asn Gly Asn Met Phe Glu Asp Gln Asn Val Asp Lys Glu 
    450                 455                 460                 


Gly Lys Ala Leu Pro Ala Thr Gly Gln Lys Ala Asn Val Ser Pro Glu 
465                 470                 475                 480 


Gln Pro Pro Leu Phe Thr His Thr Val Lys Asp Arg Asp His Ile Ser 
                485                 490                 495     


Thr Arg Phe Leu Gly Gly Met Asp Ser Leu Thr Ser Ser Glu Glu Ser 
            500                 505                 510         


Ser Glu Arg Pro Pro Leu Ser Thr Leu Thr Leu Lys Glu Ala Asp Pro 
        515                 520                 525             


Ser Ser Lys Ala Ala Met Arg Arg Lys Asp Ser Pro Pro Pro Gly Lys 
    530                 535                 540                 


Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser Asp Asp Lys 
545                 550                 555                 560 


Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Glu Gly Pro Ile Ser 
                565                 570                 575     


Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Glu Lys Ala Thr Ser Asp 
            580                 585                 590         


Glu Lys Asp Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Lys Gly Gln 
        595                 600                 605             


Gln Ser Gly Thr Val Ser Pro Gln Lys Gln Ser Ala Trp Lys Val Ile 
    610                 615                 620                 


Phe Lys Lys Lys Val Ser Leu Leu Asn Ile Ala Thr Arg Ile Met Gly 
625                 630                 635                 640 


Gly Gly Lys Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Ser Lys 
                645                 650                 655     


Ala Thr Ser Asp Lys Thr Asp Ser Ala Leu Asn Ile Ala Thr Glu Ile 
            660                 665                 670         


Lys Asp Gly Leu Gln Cys Gly Thr Val Ser Ser Gln Lys Gln Pro Ala 
        675                 680                 685             


Leu Lys Ala Thr Thr Asp Glu Glu Asp Ser Val Ser Asn Ile Ala Thr 
    690                 695                 700                 


Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln Lys Gln 
705                 710                 715                 720 


Pro Ala Leu Lys Ala Thr Thr Asp Glu Glu Asp Ser Val Ser Asn Ile 
                725                 730                 735     


Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln 
            740                 745                 750         


Lys Gln Pro Ala Leu Lys Ala Thr Thr Asp Glu Lys Asp Ser Val Ser 
        755                 760                 765             


Asn Ile Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser 
    770                 775                 780                 


Ser Gln Lys Pro Pro Ala Leu Thr Ala Thr Ser Asp Glu Glu Gly Ser 
785                 790                 795                 800 


Val Leu Ser Ile Ala Arg Glu Asn Lys Asp Gly Glu Lys Ser Arg Thr 
                805                 810                 815     


Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys 
            820                 825                 830         


Asp Ser Phe Ser Asn Ile Thr Arg Gly Lys Lys Asp Gly Glu Ile Ser 
        835                 840                 845             


Arg Lys Val Ser Ser Gln Lys Pro Pro Thr Leu Lys Gly Thr Ser Asp 
    850                 855                 860                 


Glu Glu Asp Ser Val Leu Gly Ile Ala Arg Glu Asn Lys Asp Gly Glu 
865                 870                 875                 880 


Lys Ser Arg Thr Val Ser Ser Glu Lys Pro Pro Gly Leu Lys Ala Ser 
                885                 890                 895     


Ser Ala Glu Lys Asp Ser Val Leu Asn Ile Ala Arg Gly Lys Lys Asp 
            900                 905                 910         


Gly Glu Lys Thr Lys Arg Val Ser Ser Arg Lys Lys Pro Ser Leu Glu 
        915                 920                 925             


Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser Asn Ile Thr Arg Glu Lys 
    930                 935                 940                 


Lys Asp Gly Glu Ile Ser Arg Lys Val Ser Ser Gln Lys Pro Pro Ala 
945                 950                 955                 960 


Leu Lys Gly Thr Ser Asp Glu Glu Asp Ser Val Leu Gly Ile Ala Arg 
                965                 970                 975     


Glu Asn Lys Asp Gly Glu Lys Ser Arg Thr Val Ser Ser Glu Lys Pro 
            980                 985                 990         


Pro Gly Leu Lys Ala Thr Ser Asp  Glu Lys Asp Ser Val  Leu Asn Ile 
        995                 1000                 1005             


Ala Arg  Gly Lys Lys Asp Gly  Glu Lys Thr Arg Thr  Val Ser Ser 
    1010                 1015                 1020             


Gln Lys  Pro Pro Thr Leu Lys  Ala Thr Ser Asp Glu  Glu Asp Ser 
    1025                 1030                 1035             


Val Leu  Ser Ile Ala Arg Glu  Asn Lys Asp Gly Glu  Lys Ser Arg 
    1040                 1045                 1050             


Thr Val  Ser Ser Glu Lys Pro  Ser Gly Leu Lys Ala  Thr Ser Ala 
    1055                 1060                 1065             


Glu Lys  Asp Ser Val Leu Asn  Ile Ala Arg Gly Lys  Lys Tyr Gly 
    1070                 1075                 1080             


Glu Lys  Thr Lys Arg Val Ser  Ser Arg Lys Lys Pro  Ala Leu Lys 
    1085                 1090                 1095             


Ala Thr  Ser Asp Glu Lys Asp  Ser Val Leu Tyr Ile  Ala Arg Glu 
    1100                 1105                 1110             


Lys Lys  Asp Gly Glu Lys Ser  Arg Thr Val Ser Ser  Pro Lys Gln 
    1115                 1120                 1125             


Pro Ala  Leu Lys Ala Ile Cys  Asp Lys Glu Asp Ser  Val Pro Asn 
    1130                 1135                 1140             


Met Ala  Thr Glu Lys Lys Asp  Glu Gln Ile Ser Gly  Thr Val Ser 
    1145                 1150                 1155             


Cys Gln  Lys Gln Pro Ala Leu  Lys Ala Thr Ser Asp  Lys Lys Asp 
    1160                 1165                 1170             


Ser Val  Ser Asn Ile Pro Thr  Glu Ile Lys Asp Gly  Gln Gln Ser 
    1175                 1180                 1185             


Gly Thr  Val Ser Ser Gln Lys  Gln Pro Ala Trp Lys  Ala Thr Ser 
    1190                 1195                 1200             


Val Lys  Lys Asp Ser Val Ser  Asn Ile Ala Thr Glu  Ile Lys Asp 
    1205                 1210                 1215             


Gly Gln  Ile Arg Gly Thr Gly  Ile Leu Glu Tyr Thr  Phe Asn Val 
    1220                 1225                 1230             


Met Phe  Asp Gln Ile Glu Glu  Lys Phe Thr Ser Leu  Asn Lys Ser 
    1235                 1240                 1245             


Ala Gly  Val Ser Pro Gln Lys  Gln Ser Ala Gln Lys  Val Ile Phe 
    1250                 1255                 1260             


Lys Lys  Lys Val Ser Leu Leu  Asn Ile Ala Thr Arg  Ile Thr Gly 
    1265                 1270                 1275             


Gly Trp  Lys Ser Gly Thr Glu  Tyr Pro Glu Asn Leu  Pro Thr Leu 
    1280                 1285                 1290             


Lys Ala  Thr Ile Glu Asn Lys  Asn Ser Val Leu Asn  Thr Ala Thr 
    1295                 1300                 1305             


Lys Met  Lys Asp Val Gln Thr  Ser Thr Pro Ala Glu  Gln Asp Leu 
    1310                 1315                 1320             


Glu Met  Ala Ser Glu Gly Glu  Gln Lys Arg Leu Glu  Glu Tyr Glu 
    1325                 1330                 1335             


Asn Asn  Gln Pro Gln Val Lys  Asn Gln Ile His Ser  Arg Asp Asp 
    1340                 1345                 1350             


Leu Asp  Asp Ile Ile Gln Ser  Ser Gln Thr Val Ser  Glu Asp Gly 
    1355                 1360                 1365             


Asp Ser  Leu Cys Cys Asn Cys  Lys Asn Val Ile Leu  Leu Ile Asp 
    1370                 1375                 1380             


Gln His  Glu Met Lys Cys Lys  Asp Cys Val His Leu  Leu Lys Ile 
    1385                 1390                 1395             


Lys Asn  Thr Phe Cys Leu Trp  Lys Arg Leu Ile Lys  Leu Lys Asp 
    1400                 1405                 1410             


Asn His  Cys Glu Gln Leu Arg  Val Lys Ile Arg Lys  Leu Lys Asn 
    1415                 1420                 1425             


Lys Ala  Ser Val Leu Gln Lys  Arg Ile Ser Glu Lys  Glu Glu Ile 
    1430                 1435                 1440             


Lys Ser  Gln Leu Lys His Glu  Ile Leu Glu Leu Glu  Lys Glu Leu 
    1445                 1450                 1455             


Cys Ser  Leu Arg Phe Ala Ile  Gln Gln Glu Lys Lys  Lys Arg Arg 
    1460                 1465                 1470             


Asn Val  Glu Glu Val His Gln  Lys Val Arg Glu Lys  Leu Arg Ile 
    1475                 1480                 1485             


Thr Glu  Glu Gln Tyr Arg Ile  Glu Ala Asp Val Thr  Lys Pro Ile 
    1490                 1495                 1500             


Lys Pro  Ala Leu Lys Ser Ala  Glu Val Glu Leu Lys  Thr Gly Gly 
    1505                 1510                 1515             


Asn Asn  Ser Asn Gln Val Ser  Glu Thr Asp Glu Lys  Glu Asp Leu 
    1520                 1525                 1530             


Leu His  Glu Asn Arg Leu Met  Gln Asp Glu Ile Ala  Arg Leu Arg 
    1535                 1540                 1545             


Leu Glu  Lys Asp Thr Ile Lys  Asn Gln Asn Leu Glu  Lys Lys Tyr 
    1550                 1555                 1560             


Leu Lys  Asp Phe Glu Ile Val  Lys Arg Lys His Glu  Asp Leu Gln 
    1565                 1570                 1575             


Lys Ala  Leu Lys Arg Asn Gly  Glu Thr Leu Ala Lys  Thr Ile Ala 
    1580                 1585                 1590             


Cys Tyr  Ser Gly Gln Leu Ala  Ala Leu Thr Asp Glu  Asn Thr Thr 
    1595                 1600                 1605             


Leu Arg  Ser Lys Leu Glu Lys  Gln Arg Glu Ser Arg  Gln Arg Leu 
    1610                 1615                 1620             


Glu Thr  Glu Met Gln Ser Tyr  His Cys Arg Leu Asn  Ala Ala Arg 
    1625                 1630                 1635             


Cys Asp  His Asp Gln Ser His  Ser Ser Lys Arg Asp  Gln Glu Leu 
    1640                 1645                 1650             


Ala Phe  Gln Gly Thr Val Asp  Lys Cys Arg His Leu  Gln Glu Asn 
    1655                 1660                 1665             


Leu Asn  Ser His Val Leu Ile  Leu Ser Leu Gln Leu  Ser Lys Ala 
    1670                 1675                 1680             


Glu Ser  Lys Ser Arg Val Leu  Lys Thr Glu Leu His  Tyr Thr Gly 
    1685                 1690                 1695             


Glu Ala  Leu Lys Glu Lys Ala  Leu Val Phe Glu His  Val Gln Ser 
    1700                 1705                 1710             


Glu Leu  Lys Gln Lys Gln Ser  Gln Met Lys Asp Ile  Glu Lys Met 
    1715                 1720                 1725             


Tyr Lys  Ser Gly Tyr Asn Thr  Met Glu Lys Cys Ile  Glu Lys Gln 
    1730                 1735                 1740             


Glu Arg  Phe Cys Gln Leu Lys  Lys Gln Asn Met Leu  Leu Gln Gln 
    1745                 1750                 1755             


Gln Leu  Asp Asp Ala Arg Asn  Lys Ala Asp Asn Gln  Glu Lys Ala 
    1760                 1765                 1770             


Ile Leu  Asn Ile Gln Ala Arg  Cys Asp Ala Arg Val  Gln Asn Leu 
    1775                 1780                 1785             


Gln Ala  Glu Cys Arg Lys His  Arg Leu Leu Leu Glu  Glu Asp Asn 
    1790                 1795                 1800             


Lys Met  Leu Val Asn Glu Leu  Asn His Ser Lys Glu  Lys Glu Cys 
    1805                 1810                 1815             


Gln Tyr  Glu Lys Glu Lys Ala  Glu Arg Glu Val Ala  Val Arg Gln 
    1820                 1825                 1830             


Leu Gln  Gln Lys Arg Asp Asp  Val Leu Asn Lys Gly  Ser Ala Thr 
    1835                 1840                 1845             


Lys Ala  Leu Leu Asp Ala Ser  Ser Arg His Cys Thr  Tyr Leu Glu 
    1850                 1855                 1860             


Asn Gly  Met Gln Asp Ser Arg  Lys Lys Leu Asp Gln  Met Arg Ser 
    1865                 1870                 1875             


Gln Phe  Gln Glu Ile Gln Asp  Gln Leu Thr Ala Thr  Ile Arg Cys 
    1880                 1885                 1890             


Thr Lys  Glu Met Glu Gly Asp  Thr Gln Lys Leu Glu  Val Glu His 
    1895                 1900                 1905             


Val Met  Met Arg Lys Ile Ile  Lys Lys Gln Asp Asp  Gln Ile Glu 
    1910                 1915                 1920             


Arg Leu  Glu Lys Ile Leu Gln  His Ser Ser Leu Met  Leu Gln Val 
    1925                 1930                 1935             


Phe Glu  Ser 
    1940     


<210>  547
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD37__Homo_sapiens__NP_859077

<400>  547

Met Leu Leu Leu Asp Cys Asn Pro Glu Val Asp Gly Leu Lys His Leu 
1               5                   10                  15      


Leu Glu Thr Gly Ala Ser Val Asn Ala Pro Pro Asp Pro Cys Lys Gln 
            20                  25                  30          


Ser Pro Val His Leu Ala Ala Gly Ser Gly Leu Ala Cys Phe Leu Leu 
        35                  40                  45              


Trp Gln Leu Gln Thr Gly Ala Asp Leu Asn Gln Gln Asp Val Leu Gly 
    50                  55                  60                  


Glu Ala Pro Leu His Lys Ala Ala Lys Val Gly Ser Leu Glu Cys Leu 
65                  70                  75                  80  


Ser Leu Leu Val Ala Ser Asp Ala Gln Ile Asp Leu Cys Asn Lys Asn 
                85                  90                  95      


Gly Gln Thr Ala Glu Asp Leu Ala Trp Ser Cys Gly Phe Pro Asp Cys 
            100                 105                 110         


Ala Lys Phe Leu Thr Thr Ile Lys Cys Met Gln Thr Ile Lys Ala Ser 
        115                 120                 125             


Glu His Pro Asp Arg Asn Asp Cys Val Ala Val Leu Arg Gln Lys Arg 
    130                 135                 140                 


Ser Leu Gly Ser Val Glu Asn Thr Ser Gly Lys Arg Lys Cys 
145                 150                 155             


<210>  548
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD44__Homo_sapiens__NP_001182073

<400>  548

Met Ala Val Leu Lys Leu Thr Asp Gln Pro Pro Leu Val Gln Ala Ile 
1               5                   10                  15      


Phe Ser Gly Asp Pro Glu Glu Ile Arg Met Leu Ile His Lys Thr Glu 
            20                  25                  30          


Asp Val Asn Thr Leu Asp Ser Glu Lys Arg Thr Pro Leu His Val Ala 
        35                  40                  45              


Ala Phe Leu Gly Asp Ala Glu Ile Ile Glu Leu Leu Ile Leu Ser Gly 
    50                  55                  60                  


Ala Arg Val Asn Ala Lys Asp Asn Met Trp Leu Thr Pro Leu His Arg 
65                  70                  75                  80  


Ala Val Ala Ser Arg Ser Glu Glu Ala Val Gln Val Leu Ile Lys His 
                85                  90                  95      


Ser Ala Asp Val Asn Ala Arg Asp Lys Asn Trp Gln Thr Pro Leu His 
            100                 105                 110         


Val Ala Ala Ala Asn Lys Ala Val Lys Cys Ala Glu Val Ile Ile Pro 
        115                 120                 125             


Leu Leu Ser Ser Val Asn Val Ser Asp Arg Gly Gly Arg Thr Ala Leu 
    130                 135                 140                 


His His Ala Ala Leu Asn Gly His Val Glu Met Val Asn Leu Leu Leu 
145                 150                 155                 160 


Ala Lys Gly Ala Asn Ile Asn Ala Phe Asp Lys Lys Asp Arg Arg Ala 
                165                 170                 175     


Leu His Trp Ala Ala Tyr Met Gly His Leu Asp Val Val Ala Leu Leu 
            180                 185                 190         


Ile Asn His Gly Ala Glu Val Thr Cys Lys Asp Lys Lys Gly Tyr Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Ser Asn Gly Gln Ile Asn Val Val Lys His 
    210                 215                 220                 


Leu Leu Asn Leu Gly Val Glu Ile Asp Glu Ile Asn Val Tyr Gly Asn 
225                 230                 235                 240 


Thr Ala Leu His Ile Ala Cys Tyr Asn Gly Gln Asp Ala Val Val Asn 
                245                 250                 255     


Glu Leu Ile Asp Tyr Gly Ala Asn Val Asn Gln Pro Asn Asn Asn Gly 
            260                 265                 270         


Phe Thr Pro Leu His Phe Ala Ala Ala Ser Thr His Gly Ala Leu Cys 
        275                 280                 285             


Leu Glu Leu Leu Val Asn Asn Gly Ala Asp Val Asn Ile Gln Ser Lys 
    290                 295                 300                 


Asp Gly Lys Ser Pro Leu His Met Thr Ala Val His Gly Arg Phe Thr 
305                 310                 315                 320 


Arg Ser Gln Thr Leu Ile Gln Asn Gly Gly Glu Ile Asp Cys Val Asp 
                325                 330                 335     


Lys Asp Gly Asn Thr Pro Leu His Val Ala Ala Arg Tyr Gly His Glu 
            340                 345                 350         


Leu Leu Ile Asn Thr Leu Ile Thr Ser Gly Ala Asp Thr Ala Lys Cys 
        355                 360                 365             


Gly Ile His Ser Met Phe Pro Leu His Leu Ala Ala Leu Asn Ala His 
    370                 375                 380                 


Ser Asp Cys Cys Arg Lys Leu Leu Ser Ser Gly Phe Glu Ile Asp Thr 
385                 390                 395                 400 


Pro Asp Lys Phe Gly Arg Thr Cys Leu His Ala Ala Ala Ala Gly Gly 
                405                 410                 415     


Asn Val Glu Cys Ile Lys Leu Leu Gln Ser Ser Gly Ala Asp Phe His 
            420                 425                 430         


Lys Lys Asp Lys Cys Gly Arg Thr Pro Leu His Tyr Ala Ala Ala Asn 
        435                 440                 445             


Cys His Phe His Cys Ile Glu Thr Leu Val Thr Thr Gly Ala Asn Val 
    450                 455                 460                 


Asn Glu Thr Asp Asp Trp Gly Arg Thr Ala Leu His Tyr Ala Ala Ala 
465                 470                 475                 480 


Ser Asp Met Asp Arg Asn Lys Thr Ile Leu Gly Asn Ala His Asp Asn 
                485                 490                 495     


Ser Glu Glu Leu Glu Arg Ala Arg Glu Leu Lys Glu Lys Glu Ala Thr 
            500                 505                 510         


Leu Cys Leu Glu Phe Leu Leu Gln Asn Asp Ala Asn Pro Ser Ile Arg 
        515                 520                 525             


Asp Lys Glu Gly Tyr Asn Ser Ile His Tyr Ala Ala Ala Tyr Gly His 
    530                 535                 540                 


Arg Gln Cys Leu Glu Leu Leu Leu Glu Arg Thr Asn Ser Gly Phe Glu 
545                 550                 555                 560 


Glu Ser Asp Ser Gly Ala Thr Lys Ser Pro Leu His Leu Ala Ala Tyr 
                565                 570                 575     


Asn Gly His His Gln Ala Leu Glu Val Leu Leu Gln Ser Leu Val Asp 
            580                 585                 590         


Leu Asp Ile Arg Asp Glu Lys Gly Arg Thr Ala Leu Asp Leu Ala Ala 
        595                 600                 605             


Phe Lys Gly His Thr Glu Cys Val Glu Ala Leu Ile Asn Gln Gly Ala 
    610                 615                 620                 


Ser Ile Phe Val Lys Asp Asn Val Thr Lys Arg Thr Pro Leu His Ala 
625                 630                 635                 640 


Ser Val Ile Asn Gly His Thr Leu Cys Leu Arg Leu Leu Leu Glu Ile 
                645                 650                 655     


Ala Asp Asn Pro Glu Ala Val Asp Val Lys Asp Ala Lys Gly Gln Thr 
            660                 665                 670         


Pro Leu Met Leu Ala Val Ala Tyr Gly His Ile Asp Ala Val Ser Leu 
        675                 680                 685             


Leu Leu Glu Lys Glu Ala Asn Val Asp Thr Val Asp Ile Leu Gly Cys 
    690                 695                 700                 


Thr Ala Leu His Arg Gly Ile Met Thr Gly His Glu Glu Cys Val Gln 
705                 710                 715                 720 


Met Leu Leu Glu Gln Glu Val Ser Ile Leu Cys Lys Asp Ser Arg Gly 
                725                 730                 735     


Arg Thr Pro Leu His Tyr Ala Ala Ala Arg Gly His Ala Thr Trp Leu 
            740                 745                 750         


Ser Glu Leu Leu Gln Met Ala Leu Ser Glu Glu Asp Cys Cys Phe Lys 
        755                 760                 765             


Asp Asn Gln Gly Tyr Thr Pro Leu His Trp Ala Cys Tyr Asn Gly Asn 
    770                 775                 780                 


Glu Asn Cys Ile Glu Val Leu Leu Glu Gln Lys Cys Phe Arg Lys Phe 
785                 790                 795                 800 


Ile Gly Asn Pro Phe Thr Pro Leu His Cys Ala Ile Ile Asn Asp His 
                805                 810                 815     


Gly Asn Cys Ala Ser Leu Leu Leu Gly Ala Ile Asp Ser Ser Ile Val 
            820                 825                 830         


Ser Cys Arg Asp Asp Lys Gly Arg Thr Pro Leu His Ala Ala Ala Phe 
        835                 840                 845             


Ala Asp His Val Glu Cys Leu Gln Leu Leu Leu Arg His Ser Ala Pro 
    850                 855                 860                 


Val Asn Ala Val Asp Asn Ser Gly Lys Thr Ala Leu Met Met Ala Ala 
865                 870                 875                 880 


Glu Asn Gly Gln Ala Gly Ala Val Asp Ile Leu Val Asn Ser Ala Gln 
                885                 890                 895     


Ala Asp Leu Thr Val Lys Asp Lys Asp Leu Asn Thr Pro Leu His Leu 
            900                 905                 910         


Ala Cys Ser Lys Gly His Glu Lys Cys Ala Leu Leu Ile Leu Asp Lys 
        915                 920                 925             


Ile Gln Asp Glu Ser Leu Ile Asn Glu Lys Asn Asn Ala Leu Gln Thr 
    930                 935                 940                 


Pro Leu His Val Ala Ala Arg Asn Gly Leu Lys Val Val Val Glu Glu 
945                 950                 955                 960 


Leu Leu Ala Lys Gly Ala Cys Val Leu Ala Val Asp Glu Asn Ala Ser 
                965                 970                 975     


Arg Ser Asn Gly Pro Arg Ser Thr Pro Gly Thr Ala Val Gln Lys Glu 
            980                 985                 990         


Glu 
    


<210>  549
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD45__Homo_sapiens__XP_011507772

<400>  549

Met Glu Ser Glu Gly Pro Pro Glu Ser Glu Ser Ser Glu Phe Phe Ser 
1               5                   10                  15      


Gln Gln Glu Glu Glu Asn Glu Glu Glu Glu Ala Gln Glu Pro Glu Glu 
            20                  25                  30          


Thr Gly Pro Lys Asn Pro Leu Leu Gln Pro Ala Leu Thr Gly Asp Val 
        35                  40                  45              


Glu Gly Leu Gln Lys Ile Phe Glu Asp Pro Glu Asn Pro His His Glu 
    50                  55                  60                  


Gln Ala Met Gln Leu Leu Leu Glu Glu Asp Ile Val Gly Arg Asn Leu 
65                  70                  75                  80  


Leu Tyr Ala Ala Cys Met Ala Gly Gln Ser Asp Val Ile Arg Ala Leu 
                85                  90                  95      


Ala Lys Tyr Gly Val Asn Leu Asn Glu Lys Thr Thr Arg Gly Tyr Thr 
            100                 105                 110         


Leu Leu His Cys Ala Ala Ala Trp Gly Arg Leu Glu Thr Leu Lys Ala 
        115                 120                 125             


Leu Val Glu Leu Asp Val Asp Ile Glu Ala Leu Asn Phe Arg Glu Glu 
    130                 135                 140                 


Arg Ala Arg Asp Val Ala Ala Arg Tyr Ser Gln Thr Glu Cys Val Glu 
145                 150                 155                 160 


Phe Leu Asp Trp Ala Asp Ala Arg Leu Thr Leu Lys Lys Tyr Ile Ala 
                165                 170                 175     


Lys Val Ser Leu Ala Val Thr Asp Thr Glu Lys Gly Ser Gly Lys Leu 
            180                 185                 190         


Leu Lys Glu Asp Lys Asn Thr Ile Leu Ser Ala Cys Arg Ala Lys Asn 
        195                 200                 205             


Glu Trp Leu Glu Thr His Thr Glu Ala Ser Ile Asn Glu Leu Phe Glu 
    210                 215                 220                 


Gln Arg Gln Gln Leu Glu Asp Ile Val Thr Pro Ile Phe Thr Lys Met 
225                 230                 235                 240 


Thr Thr Pro Cys Gln Val Lys Ser Ala Lys Ser Val Thr Ser His Asp 
                245                 250                 255     


Gln Lys Arg Ser Gln Asp Asp Thr Ser Asn 
            260                 265     


<210>  550
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD46__Homo_sapiens__NP_001257308

<400>  550

Met Ser Tyr Val Phe Val Asn Asp Ser Ser Gln Thr Asn Val Pro Leu 
1               5                   10                  15      


Leu Gln Ala Cys Ile Asp Gly Asp Phe Asn Tyr Ser Lys Arg Leu Leu 
            20                  25                  30          


Glu Ser Gly Phe Asp Pro Asn Ile Arg Asp Ser Arg Gly Arg Thr Gly 
        35                  40                  45              


Leu His Leu Ala Ala Ala Arg Gly Asn Val Asp Ile Cys Gln Leu Leu 
    50                  55                  60                  


His Lys Phe Gly Ala Asp Leu Leu Ala Thr Asp Tyr Gln Gly Asn Thr 
65                  70                  75                  80  


Ala Leu His Leu Cys Gly His Val Asp Thr Ile Gln Phe Leu Val Ser 
                85                  90                  95      


Asn Gly Leu Lys Ile Asp Ile Cys Asn His Gln Gly Ala Thr Pro Leu 
            100                 105                 110         


Val Leu Ala Lys Arg Arg Gly Val Asn Lys Asp Val Ile Arg Leu Leu 
        115                 120                 125             


Glu Ser Leu Glu Glu Gln Glu Val Lys Gly Phe Asn Arg Gly Thr His 
    130                 135                 140                 


Ser Lys Leu Glu Thr Met Gln Thr Ala Glu Ser Glu Ser Ala Met Glu 
145                 150                 155                 160 


Ser His Ser Leu Leu Asn Pro Asn Leu Gln Gln Gly Glu Gly Val Leu 
                165                 170                 175     


Ser Ser Phe Arg Thr Thr Trp Gln Glu Phe Val Glu Asp Leu Gly Phe 
            180                 185                 190         


Trp Arg Val Leu Leu Leu Ile Phe Val Ile Ala Leu Leu Ser Leu Gly 
        195                 200                 205             


Ile Ala Tyr Tyr Arg Arg Thr Leu Arg Leu Gly Ser Phe Ala Arg Gln 
    210                 215                 220                 


Asp Arg Ser Arg Ile Gln Ala Ile 
225                 230         


<210>  551
<211>  1250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD50__Homo_sapiens__NP_001161354

<400>  551

Met Lys Pro Pro Gln Gln Ser Leu Tyr Leu Leu Val Asp Ser Val Asp 
1               5                   10                  15      


Glu Gly Cys Asn Ile Thr Glu Gly Glu Gln Thr Ser Thr Ser Leu Ser 
            20                  25                  30          


Gly Thr Val Ala Ala Leu Leu Ala Gly His His Glu Phe Phe Pro Pro 
        35                  40                  45              


Trp Leu Leu Leu Leu Cys Ser Ala Arg Lys Gln Ser Lys Ala Val Thr 
    50                  55                  60                  


Lys Met Phe Thr Gly Phe Arg Lys Ile Ser Leu Asp Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Tyr Ile Val Lys Asp Val Gln Gln Tyr Ile Leu His Arg Leu Asp 
                85                  90                  95      


Gln Glu Glu Ala Leu Arg Gln His Leu Thr Lys Glu Thr Ala Glu Met 
            100                 105                 110         


Leu Asn Gln Leu His Ile Lys Ser Ser Gly Cys Phe Leu Tyr Leu Glu 
        115                 120                 125             


Arg Val Leu Asp Gly Val Val Glu Asn Phe Ile Met Leu Arg Glu Ile 
    130                 135                 140                 


Arg Asp Ile Pro Gly Thr Leu Asn Gly Leu Tyr Leu Trp Leu Cys Gln 
145                 150                 155                 160 


Arg Leu Phe Val Arg Lys Gln Phe Ala Lys Val Gln Pro Ile Leu Asn 
                165                 170                 175     


Val Ile Leu Ala Ala Cys Arg Pro Leu Thr Ile Thr Glu Leu Tyr His 
            180                 185                 190         


Ala Val Trp Thr Lys Asn Met Ser Leu Thr Leu Glu Asp Phe Gln Arg 
        195                 200                 205             


Lys Leu Asp Ile Leu Ser Lys Leu Leu Val Asp Gly Leu Gly Asn Thr 
    210                 215                 220                 


Lys Ile Leu Phe His Tyr Ser Phe Ala Glu Trp Leu Leu Asp Val Lys 
225                 230                 235                 240 


His Cys Thr Gln Lys Tyr Leu Cys Asn Ala Ala Glu Gly His Arg Met 
                245                 250                 255     


Leu Ala Met Ser Tyr Thr Cys Gln Ala Lys Asn Leu Thr Pro Leu Glu 
            260                 265                 270         


Ala Gln Glu Phe Ala Leu His Leu Ile Asn Ser Asn Leu Gln Leu Glu 
        275                 280                 285             


Thr Ala Glu Leu Ala Leu Trp Met Ile Trp Asn Gly Thr Pro Val Arg 
    290                 295                 300                 


Asp Ser Leu Ser Thr Leu Ile Pro Lys Glu Gln Glu Val Leu Gln Leu 
305                 310                 315                 320 


Leu Val Lys Ala Gly Ala His Val Asn Ser Glu Asp Asp Arg Thr Ser 
                325                 330                 335     


Cys Ile Val Arg Gln Ala Leu Glu Arg Glu Asp Ser Ile Arg Thr Leu 
            340                 345                 350         


Leu Asp Asn Gly Ala Ser Val Asn Gln Cys Asp Ser Asn Gly Arg Thr 
        355                 360                 365             


Leu Leu Ala Asn Ala Ala Tyr Ser Gly Ser Leu Asp Val Val Asn Leu 
    370                 375                 380                 


Leu Val Ser Arg Gly Ala Asp Leu Glu Ile Glu Asp Ala His Gly His 
385                 390                 395                 400 


Thr Pro Leu Thr Leu Ala Ala Arg Gln Gly His Thr Lys Val Val Asn 
                405                 410                 415     


Cys Leu Ile Gly Cys Gly Ala Asn Ile Asn His Thr Asp Gln Asp Gly 
            420                 425                 430         


Trp Thr Ala Leu Arg Ser Ala Ala Trp Gly Gly His Thr Glu Val Val 
        435                 440                 445             


Ser Ala Leu Leu Tyr Ala Gly Val Lys Val Asp Cys Ala Asp Ala Asp 
    450                 455                 460                 


Ser Arg Thr Ala Leu Arg Ala Ala Ala Trp Gly Gly His Glu Asp Ile 
465                 470                 475                 480 


Val Leu Asn Leu Leu Gln His Gly Ala Glu Val Asn Lys Ala Asp Asn 
                485                 490                 495     


Glu Gly Arg Thr Ala Leu Ile Ala Ala Ala Tyr Met Gly His Arg Glu 
            500                 505                 510         


Ile Val Glu His Leu Leu Asp His Gly Ala Glu Val Asn His Glu Asp 
        515                 520                 525             


Val Asp Gly Arg Thr Ala Leu Ser Val Ala Ala Leu Cys Val Pro Ala 
    530                 535                 540                 


Ser Lys Gly His Ala Ser Val Val Ser Leu Leu Ile Asp Arg Gly Ala 
545                 550                 555                 560 


Glu Val Asp His Cys Asp Lys Asp Gly Met Thr Pro Leu Leu Val Ala 
                565                 570                 575     


Ala Tyr Glu Gly His Val Asp Val Val Asp Leu Leu Leu Glu Gly Gly 
            580                 585                 590         


Ala Asp Val Asp His Thr Asp Asn Asn Gly Arg Thr Pro Leu Leu Ala 
        595                 600                 605             


Ala Ala Ser Met Gly His Ala Ser Val Val Asn Thr Leu Leu Phe Trp 
    610                 615                 620                 


Gly Ala Ala Val Asp Ser Ile Asp Ser Glu Gly Arg Thr Val Leu Ser 
625                 630                 635                 640 


Ile Ala Ser Ala Gln Gly Asn Val Glu Val Val Arg Thr Leu Leu Asp 
                645                 650                 655     


Arg Gly Leu Asp Glu Asn His Arg Asp Asp Ala Gly Trp Thr Pro Leu 
            660                 665                 670         


His Met Ala Ala Phe Glu Gly His Arg Leu Ile Cys Glu Ala Leu Ile 
        675                 680                 685             


Glu Gln Gly Ala Arg Thr Asn Glu Ile Asp Asn Asp Gly Arg Ile Pro 
    690                 695                 700                 


Phe Ile Leu Ala Ser Gln Glu Gly His Tyr Asp Cys Val Gln Ile Leu 
705                 710                 715                 720 


Leu Glu Asn Lys Ser Asn Ile Asp Gln Arg Gly Tyr Asp Gly Arg Asn 
                725                 730                 735     


Ala Leu Arg Val Ala Ala Leu Glu Gly His Arg Asp Ile Val Glu Leu 
            740                 745                 750         


Leu Phe Ser His Gly Ala Asp Val Asn Cys Lys Asp Ala Asp Gly Arg 
        755                 760                 765             


Pro Thr Leu Tyr Ile Leu Ala Leu Glu Asn Gln Leu Thr Met Ala Glu 
    770                 775                 780                 


Tyr Phe Leu Glu Asn Gly Ala Asn Val Glu Ala Ser Asp Ala Glu Gly 
785                 790                 795                 800 


Arg Thr Ala Leu His Val Ser Cys Trp Gln Gly His Met Glu Met Val 
                805                 810                 815     


Gln Val Leu Ile Ala Tyr His Ala Asp Val Asn Ala Ala Asp Asn Glu 
            820                 825                 830         


Lys Arg Ser Ala Leu Gln Ser Ala Ala Trp Gln Gly His Val Lys Val 
        835                 840                 845             


Val Gln Leu Leu Ile Glu His Gly Ala Val Val Asp His Thr Cys Asn 
    850                 855                 860                 


Gln Gly Ala Thr Ala Leu Cys Ile Ala Ala Gln Glu Gly His Ile Asp 
865                 870                 875                 880 


Val Val Gln Val Leu Leu Glu His Gly Ala Asp Pro Asn His Ala Asp 
                885                 890                 895     


Gln Phe Gly Arg Thr Ala Met Arg Val Ala Ala Lys Asn Gly His Ser 
            900                 905                 910         


Gln Ile Ile Lys Leu Leu Glu Lys Tyr Gly Ala Ser Ser Leu Asn Gly 
        915                 920                 925             


Cys Ser Pro Ser Pro Val His Thr Met Glu Gln Lys Pro Leu Gln Ser 
    930                 935                 940                 


Leu Ser Ser Lys Val Gln Ser Leu Thr Ile Lys Ser Asn Ser Ser Gly 
945                 950                 955                 960 


Ser Thr Gly Gly Gly Asp Met Gln Pro Ser Leu Arg Gly Leu Pro Asn 
                965                 970                 975     


Gly Pro Thr His Ala Phe Ser Ser Pro Ser Glu Ser Pro Asp Ser Thr 
            980                 985                 990         


Val Asp Arg Gln Lys Ser Ser Leu  Ser Asn Asn Ser Leu  Lys Ser Ser 
        995                 1000                 1005             


Lys Asn  Ser Ser Leu Arg Thr  Thr Ser Ser Thr Ala  Thr Ala Gln 
    1010                 1015                 1020             


Thr Val  Pro Ile Asp Ser Phe  His Asn Leu Ser Phe  Thr Glu Gln 
    1025                 1030                 1035             


Ile Gln  Gln His Ser Leu Pro  Arg Ser Arg Ser Arg  Gln Ser Ile 
    1040                 1045                 1050             


Val Ser  Pro Ser Ser Thr Thr  Gln Ser Leu Gly Gln  Ser His Asn 
    1055                 1060                 1065             


Ser Pro  Ser Ser Glu Phe Glu  Trp Ser Gln Val Lys  Pro Ser Leu 
    1070                 1075                 1080             


Lys Ser  Thr Lys Ala Ser Lys  Gly Gly Lys Ser Glu  Asn Ser Ala 
    1085                 1090                 1095             


Lys Ser  Gly Ser Ala Gly Lys  Lys Ala Lys Gln Ser  Asn Ser Ser 
    1100                 1105                 1110             


Gln Pro  Lys Val Leu Glu Tyr  Glu Met Thr Gln Phe  Asp Arg Arg 
    1115                 1120                 1125             


Gly Pro  Ile Ala Lys Ser Gly  Thr Ala Ala Pro Pro  Lys Gln Met 
    1130                 1135                 1140             


Pro Ala  Glu Ser Gln Cys Lys  Ile Met Ile Pro Ser  Ala Gln Gln 
    1145                 1150                 1155             


Glu Ile  Gly Arg Ser Gln Gln  Gln Phe Leu Ile His  Gln Gln Ser 
    1160                 1165                 1170             


Gly Glu  Gln Lys Lys Arg Asn  Gly Ile Met Thr Asn  Pro Asn Tyr 
    1175                 1180                 1185             


His Leu  Gln Ser Asn Gln Val  Phe Leu Gly Arg Val  Ser Val Pro 
    1190                 1195                 1200             


Arg Thr  Met Gln Asp Arg Gly  His Gln Glu Val Leu  Glu Gly Tyr 
    1205                 1210                 1215             


Pro Ser  Ser Glu Thr Glu Leu  Ser Leu Lys Gln Ala  Leu Lys Leu 
    1220                 1225                 1230             


Gln Ile  Glu Gly Ser Asp Pro  Ser Phe Asn Tyr Lys  Lys Glu Thr 
    1235                 1240                 1245             


Pro Leu  
    1250 


<210>  552
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD55__Homo_sapiens__NP_078945

<400>  552

Met Met Arg Gln Ala Thr Met Asp Phe Ser Thr Pro Ser Val Phe Asp 
1               5                   10                  15      


Gln Gln Arg Gly Asp Ser Ser Glu Glu Val Asp Leu Thr Met Val Tyr 
            20                  25                  30          


Gln Ala Ala Ser Asn Gly Asp Val Asn Ala Leu Thr Ala Val Ile Arg 
        35                  40                  45              


Glu Asp Pro Ser Ile Leu Glu Cys Cys Asp Ser Glu Gly Cys Thr Pro 
    50                  55                  60                  


Leu Met His Ala Val Ser Gly Arg Gln Ala Asp Thr Val Lys Leu Leu 
65                  70                  75                  80  


Leu Lys Met Gly Ala Asn Ile Asn Met Gln Asp Ala Tyr Gly Arg Thr 
                85                  90                  95      


Ser Leu Cys Leu Ala Thr Tyr Leu Gly Trp Leu Glu Gly Cys Val Ser 
            100                 105                 110         


Leu Leu Arg Asn Gly Ala Lys His Asn Ile Pro Asp Lys Asn Gly Arg 
        115                 120                 125             


Leu Pro Leu His Ala Ala Thr Ala Glu Pro Asp Met Arg Leu Leu Thr 
    130                 135                 140                 


Val Leu Leu Gln Gln Ser Asn Ile Ser Glu Ile Asn His Gln Asp Asn 
145                 150                 155                 160 


Glu Gly Met Thr Pro Leu His Trp Ala Ala Phe His Asn Gln Pro Gln 
                165                 170                 175     


His Thr Gln Met Leu Leu Lys Lys Gly Ala Asp Pro Thr Leu Val Asp 
            180                 185                 190         


Lys Asp Phe Lys Thr Ala Leu His Trp Ala Val Gln Ser Gly Asn Arg 
        195                 200                 205             


Ile Leu Cys Ser Ile Ile Leu Ser His His Gln Gly Pro Ser Ile Ile 
    210                 215                 220                 


Asn Tyr Asp Asp Glu Ser Gly Lys Thr Cys Val His Ile Ala Ala Ala 
225                 230                 235                 240 


Ala Gly Phe Ser Asp Ile Ile His Glu Leu Ala Arg Val Pro Glu Cys 
                245                 250                 255     


Asn Leu Gln Ala Leu Asp Val Asp Asp Arg Thr Pro Leu His Trp Ala 
            260                 265                 270         


Ala Ala Ala Gly Lys Ala Glu Cys Val Gln Ser Leu Leu Glu Leu Gly 
        275                 280                 285             


Met Asp Ser Asn Leu Arg Asp Ile Asn Glu Ser Thr Pro Leu Ala Tyr 
    290                 295                 300                 


Ala Leu Tyr Cys Gly His Thr Ala Cys Val Lys Leu Leu Ser Gln Glu 
305                 310                 315                 320 


Ser Arg Thr Glu Pro Thr Arg Pro Pro Pro Ser Gln Ser Ser Arg Pro 
                325                 330                 335     


Gln Lys Lys Glu Arg Arg Phe Asn Val Leu Asn Gln Ile Phe Cys Lys 
            340                 345                 350         


Asn Lys Lys Glu Glu Gln Arg Ala His Gln Lys Asp Pro Ser Arg Asp 
        355                 360                 365             


Arg Tyr Arg Glu Glu Asp Thr Ser Glu Val Asn Asp Ile Ile Thr Thr 
    370                 375                 380                 


Phe Asp Ser Ile Val Gly Thr Asn Cys Gln Glu Gln Pro Gly Asp Gln 
385                 390                 395                 400 


Val Ala Met Val Glu Phe Lys Lys Lys Thr Ser Asp Asn Ser Lys Tyr 
                405                 410                 415     


Leu Leu Pro Glu Lys Lys Pro Leu Ala Arg Lys Gly Leu Pro Pro Ile 
            420                 425                 430         


Arg Thr Gln Ser Leu Pro Pro Ile Thr Leu Gly Asn Asn Phe Leu Thr 
        435                 440                 445             


Ala Ser His Arg Ala Thr Ser His Ala Gly Leu Ser Ser Ala Pro His 
    450                 455                 460                 


His Met Ala Gln Arg Ser Gln Lys Ser Arg Ser Glu Gln Asp Leu Leu 
465                 470                 475                 480 


Asn Asn Arg Thr Gly Cys Gln Met Leu Leu Asp Asn Pro Trp Lys Ser 
                485                 490                 495     


Asp Ser Asn Gln Val Phe Ser Tyr Lys Val Trp Thr Val Ser Ser Ser 
            500                 505                 510         


Asp Lys Leu Leu Asp Arg Leu Leu Ser Val Arg Pro Gly His Gln Glu 
        515                 520                 525             


Val Ser Val Pro Pro His Leu Arg His Leu His Asn Pro Ser Ser Gly 
    530                 535                 540                 


Gln Asn Phe Gln His Leu Ser Pro Asn Arg His Lys Ile Arg Asp Leu 
545                 550                 555                 560 


Pro Phe Thr Arg Asn Asn Leu Ala Pro Leu Pro Asp Gln Lys Phe Leu 
                565                 570                 575     


Ser Gly Glu Pro Leu Arg Thr Asn Arg Val Leu Pro Ala Ile Pro Ser 
            580                 585                 590         


Gln Arg Arg His Ser Thr Ala Ala Glu Glu Ser Glu His Ser Ala Asn 
        595                 600                 605             


Pro Thr Ser Asp Glu Asn 
    610                 


<210>  553
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD6__Homo_sapiens__NP_001229738

<400>  553

Met Ser Gln Gln Asp Ala Val Ala Ala Leu Ser Glu Arg Leu Leu Val 
1               5                   10                  15      


Ala Ala Tyr Lys Gly Gln Thr Glu Asn Val Val Gln Leu Ile Asn Lys 
            20                  25                  30          


Gly Ala Arg Val Ala Val Thr Lys His Gly Arg Thr Pro Leu His Leu 
        35                  40                  45              


Ala Ala Asn Lys Gly His Leu Pro Val Val Gln Ile Leu Leu Lys Ala 
    50                  55                  60                  


Gly Cys Asp Leu Asp Val Gln Asp Asp Gly Asp Gln Thr Ala Leu His 
65                  70                  75                  80  


Arg Ala Thr Val Val Gly Asn Thr Glu Ile Ile Ala Ala Leu Ile His 
                85                  90                  95      


Glu Gly Cys Ala Leu Asp Arg Gln Asp Lys Asp Gly Asn Thr Ala Leu 
            100                 105                 110         


His Glu Ala Ser Trp His Gly Phe Ser Gln Ser Ala Lys Leu Leu Ile 
        115                 120                 125             


Lys Ala Gly Ala Asn Val Leu Ala Lys Asn Lys Ala Gly Asn Thr Ala 
    130                 135                 140                 


Leu His Leu Ala Cys Gln Asn Ser His Ser Gln Ser Thr Arg Val Leu 
145                 150                 155                 160 


Leu Leu Ala Gly Ser Arg Ala Asp Leu Lys Asn Asn Ala Gly Asp Thr 
                165                 170                 175     


Cys Leu His Val Ala Ala Arg Tyr Asn His Leu Ser Ile Ile Arg Leu 
            180                 185                 190         


Leu Leu Thr Ala Phe Cys Ser Val His Glu Lys Asn Gln Ala Gly Asp 
        195                 200                 205             


Thr Ala Leu His Val Ala Ala Ala Leu Asn His Lys Lys Val Ala Lys 
    210                 215                 220                 


Ile Leu Leu Glu Ala Gly Ala Asp Thr Thr Ile Val Asn Asn Ala Gly 
225                 230                 235                 240 


Gln Thr Pro Leu Glu Thr Ala Arg Tyr His Asn Asn Pro Glu Val Ala 
                245                 250                 255     


Leu Leu Leu Thr Lys Ala Pro Gln Val Leu Arg Phe Ser Arg Gly Arg 
            260                 265                 270         


Ser Leu Arg Lys Lys Arg Glu Arg Leu Lys Glu Glu Arg Arg Ala Gln 
        275                 280                 285             


Ser Val Pro Arg Asp Glu Val Ala Gln Ser Lys Gly Ser Val Ser Ala 
    290                 295                 300                 


Gly Asp Thr Pro Ser Ser Glu Gln Ala Val Ala Arg Lys Glu Glu Ala 
305                 310                 315                 320 


Arg Glu Glu Phe Leu Ser Ala Ser Pro Glu Pro Arg Ala Lys Asp Asp 
                325                 330                 335     


Arg Arg Arg Lys Ser Arg Pro Lys Val Ser Ala Phe Ser Asp Pro Thr 
            340                 345                 350         


Pro Pro Ala Asp Gln Gln Pro Gly His Gln Lys Asn Leu His Ala His 
        355                 360                 365             


Asn His Pro Lys Lys Arg Asn Arg His Arg Cys Ser Ser Pro Pro Pro 
    370                 375                 380                 


Pro His Glu Phe Arg Ala Tyr Gln Leu Tyr Thr Leu Tyr Arg Gly Lys 
385                 390                 395                 400 


Asp Gly Lys Val Met Gln Ala Pro Ile Asn Gly Cys Arg Cys Glu Pro 
                405                 410                 415     


Leu Ile Asn Lys Leu Glu Asn Gln Leu Glu Ala Thr Val Glu Glu Ile 
            420                 425                 430         


Lys Ala Glu Leu Gly Ser Val Gln Asp Lys Met Asn Thr Lys Leu Gly 
        435                 440                 445             


Gln Met Glu Asn Lys Thr Gln His Gln Met Arg Val Leu Asp Lys Leu 
    450                 455                 460                 


Met Val Glu Arg Leu Ser Ala Glu Arg Thr Glu Cys Leu Asn Arg Leu 
465                 470                 475                 480 


Gln Gln His Ser Asp Thr Glu Lys His Glu Gly Glu Lys Arg Gln Ile 
                485                 490                 495     


Ser Leu Val Asp Glu Leu Lys Thr Trp Cys Met Leu Lys Ile Gln Asn 
            500                 505                 510         


Leu Glu Gln Lys Leu Ser Gly Asp Ser Arg Ala Cys Arg Ala Lys Ser 
        515                 520                 525             


Thr Pro Ser Thr Cys Glu Ser Ser Thr Gly Val Asp Gln Leu Val Val 
    530                 535                 540                 


Thr Ala Gly Pro Ala Ala Ala Ser Asp Ser Ser Pro Pro Val Val Arg 
545                 550                 555                 560 


Pro Lys Glu Lys Ala Leu Asn Ser Thr Ala Thr Gln Arg Leu Gln Gln 
                565                 570                 575     


Glu Leu Ser Ser Ser Asp Cys Thr Gly Ser Arg Leu Arg Asn Val Lys 
            580                 585                 590         


Val Gln Thr Ala Leu Leu Pro Met Asn Glu Ala Ala Arg Ser Asp Gln 
        595                 600                 605             


Gln Ala Gly Pro Cys Val Asn Arg Gly Thr Gln Thr Lys Lys Ser Gly 
    610                 615                 620                 


Lys Ser Gly Pro Thr Arg His Arg Ala Gln Gln Pro Ala Ala Ser Ser 
625                 630                 635                 640 


Thr Cys Gly Gln Pro Pro Pro Ala Thr Gly Ser Glu Gln Thr Gly Pro 
                645                 650                 655     


His Ile Arg Asp Thr Ser Gln Ala Leu Glu Leu Thr Gln Tyr Phe Phe 
            660                 665                 670         


Glu Ala Val Ser Thr Gln Met Glu Lys Trp Tyr Glu Arg Lys Ile Glu 
        675                 680                 685             


Glu Ala Arg Ser Gln Ala Asn Gln Lys Ala Gln Gln Asp Lys Ala Thr 
    690                 695                 700                 


Leu Lys Glu His Ile Lys Ser Leu Glu Glu Glu Leu Ala Lys Leu Arg 
705                 710                 715                 720 


Thr Arg Val Gln Lys Glu Asn 
                725         


<210>  554
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKRD7__Homo_sapiens__NP_062618

<400>  554

Met Asn Lys Leu Phe Ser Phe Trp Lys Arg Lys Asn Glu Thr Arg Ser 
1               5                   10                  15      


Gln Gly Tyr Asn Leu Arg Glu Lys Asp Leu Lys Lys Leu His Arg Ala 
            20                  25                  30          


Ala Ser Val Gly Asp Leu Lys Lys Leu Lys Glu Tyr Leu Gln Ile Lys 
        35                  40                  45              


Lys Tyr Asp Val Asn Met Gln Asp Lys Lys Tyr Arg Thr Pro Leu His 
    50                  55                  60                  


Leu Ala Cys Ala Asn Gly His Thr Asp Val Val Leu Phe Leu Ile Glu 
65                  70                  75                  80  


Gln Gln Cys Lys Ile Asn Val Arg Asp Ser Glu Asn Lys Ser Pro Leu 
                85                  90                  95      


Ile Lys Ala Val Gln Cys Gln Asn Glu Asp Cys Ala Thr Ile Leu Leu 
            100                 105                 110         


Asn Phe Gly Ala Asp Pro Asp Leu Arg Asp Ile Arg Tyr Asn Thr Val 
        115                 120                 125             


Leu His Tyr Ala Val Cys Gly Gln Ser Leu Ser Leu Val Glu Lys Leu 
    130                 135                 140                 


Leu Glu Tyr Glu Ala Asp Leu Glu Ala Lys Asn Lys Asp Gly Tyr Thr 
145                 150                 155                 160 


Pro Leu Leu Val Ala Val Ile Asn Asn Asn Pro Lys Met Val Lys Phe 
                165                 170                 175     


Leu Leu Glu Lys Gly Ala Asp Val Asn Ala Ser Asp Asn Tyr Gln Arg 
            180                 185                 190         


Thr Ala Leu Ile Leu Ala Val Ser Gly Glu Pro Pro Cys Leu Val Lys 
        195                 200                 205             


Leu Leu Leu Gln Gln Gly Val Glu Leu Cys Tyr Glu Gly Ile Val Asp 
    210                 215                 220                 


Ser Gln Leu Arg Asn Met Phe Ile Ser Met Val Leu Leu His Arg Tyr 
225                 230                 235                 240 


Pro Gln Phe Thr Ala Ser His Gly Lys Lys Lys His Ala Lys 
                245                 250                 


<210>  555
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKS1A__Homo_sapiens__NP_056060

<400>  555

Met Gly Lys Glu Gln Glu Leu Leu Glu Ala Ala Arg Thr Gly His Leu 
1               5                   10                  15      


Pro Ala Val Glu Lys Leu Leu Ser Gly Lys Arg Leu Ser Ser Gly Phe 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Leu Gly Ser Ser Ser His Pro Leu Ser Ser Leu 
    50                  55                  60                  


Leu Ser Met Trp Arg Gly Pro Asn Val Asn Cys Val Asp Ser Thr Gly 
65                  70                  75                  80  


Tyr Thr Pro Leu His His Ala Ala Leu Asn Gly His Lys Asp Val Val 
                85                  90                  95      


Glu Val Leu Leu Arg Asn Asp Ala Leu Thr Asn Val Ala Asp Ser Lys 
            100                 105                 110         


Gly Cys Tyr Pro Leu His Leu Ala Ala Trp Lys Gly Asp Ala Gln Ile 
        115                 120                 125             


Val Arg Leu Leu Ile His Gln Gly Pro Ser His Thr Arg Val Asn Glu 
    130                 135                 140                 


Gln Asn Asn Asp Asn Glu Thr Ala Leu His Cys Ala Ala Gln Tyr Gly 
145                 150                 155                 160 


His Thr Glu Val Val Lys Val Leu Leu Glu Glu Leu Thr Asp Pro Thr 
                165                 170                 175     


Met Arg Asn Asn Lys Phe Glu Thr Pro Leu Asp Leu Ala Ala Leu Tyr 
            180                 185                 190         


Gly Arg Leu Glu Val Val Lys Met Leu Leu Asn Ala His Pro Asn Leu 
        195                 200                 205             


Leu Ser Cys Asn Thr Lys Lys His Thr Pro Leu His Leu Ala Ala Arg 
    210                 215                 220                 


Asn Gly His Lys Ala Val Val Gln Val Leu Leu Asp Ala Gly Met Asp 
225                 230                 235                 240 


Ser Asn Tyr Gln Thr Glu Met Gly Ser Ala Leu His Glu Ala Ala Leu 
                245                 250                 255     


Phe Gly Lys Thr Asp Val Val Gln Ile Leu Leu Ala Ala Gly Thr Asp 
            260                 265                 270         


Val Asn Ile Lys Asp Asn His Gly Leu Thr Ala Leu Asp Thr Val Arg 
        275                 280                 285             


Glu Leu Pro Ser Gln Lys Ser Gln Gln Ile Ala Ala Leu Ile Glu Asp 
    290                 295                 300                 


His Met Thr Gly Lys Arg Ser Thr Lys Glu Val Asp Lys Thr Pro Pro 
305                 310                 315                 320 


Pro Gln Pro Pro Leu Ile Ser Ser Met Asp Ser Ile Ser Gln Lys Ser 
                325                 330                 335     


Gln Gly Asp Val Glu Lys Ala Val Thr Glu Leu Ile Ile Asp Phe Asp 
            340                 345                 350         


Ala Asn Ala Glu Glu Glu Gly Pro Tyr Glu Ala Leu Tyr Asn Ala Ile 
        355                 360                 365             


Ser Cys His Ser Leu Asp Ser Met Ala Ser Gly Arg Ser Ser Asp Gln 
    370                 375                 380                 


Asp Ser Thr Asn Lys Glu Ala Glu Ala Ala Gly Val Lys Pro Ala Gly 
385                 390                 395                 400 


Val Arg Pro Arg Glu Arg Pro Pro Pro Pro Ala Lys Pro Pro Pro Asp 
                405                 410                 415     


Glu Glu Glu Glu Asp His Ile Asp Lys Lys Tyr Phe Pro Leu Thr Ala 
            420                 425                 430         


Ser Glu Val Leu Ser Met Arg Pro Arg Ile His Gly Ser Ala Ala Arg 
        435                 440                 445             


Glu Glu Asp Glu His Pro Tyr Glu Leu Leu Leu Thr Ala Glu Thr Lys 
    450                 455                 460                 


Lys Val Val Leu Val Asp Gly Lys Thr Lys Asp His Arg Arg Ser Ser 
465                 470                 475                 480 


Ser Ser Arg Ser Gln Asp Ser Ala Glu Gly Gln Asp Gly Gln Val Pro 
                485                 490                 495     


Glu Gln Phe Ser Gly Leu Leu His Gly Ser Ser Pro Val Cys Glu Val 
            500                 505                 510         


Gly Gln Asp Pro Phe Gln Leu Leu Cys Thr Ala Gly Gln Ser His Pro 
        515                 520                 525             


Asp Gly Ser Pro Gln Gln Gly Ala Cys His Lys Ala Ser Met Gln Leu 
    530                 535                 540                 


Glu Glu Thr Gly Val His Ala Pro Gly Ala Ser Gln Pro Ser Ala Leu 
545                 550                 555                 560 


Asp Gln Ser Lys Arg Val Gly Tyr Leu Thr Gly Leu Pro Thr Thr Asn 
                565                 570                 575     


Ser Arg Ser His Pro Glu Thr Leu Thr His Thr Ala Ser Pro His Pro 
            580                 585                 590         


Gly Gly Ala Glu Glu Gly Asp Arg Ser Gly Ala Arg Ser Arg Ala Pro 
        595                 600                 605             


Pro Thr Ser Lys Pro Lys Ala Glu Leu Lys Leu Ser Arg Ser Leu Ser 
    610                 615                 620                 


Lys Ser Asp Ser Asp Leu Leu Thr Cys Ser Pro Thr Glu Asp Ala Thr 
625                 630                 635                 640 


Met Gly Ser Arg Ser Glu Ser Leu Ser Asn Cys Ser Ile Gly Lys Lys 
                645                 650                 655     


Arg Leu Glu Lys Ser Pro Ser Phe Ala Ser Glu Trp Asp Glu Ile Glu 
            660                 665                 670         


Lys Ile Met Ser Ser Ile Gly Glu Gly Ile Asp Phe Ser Gln Glu Arg 
        675                 680                 685             


Gln Lys Ile Ser Gly Leu Arg Thr Leu Glu Gln Ser Val Gly Glu Trp 
    690                 695                 700                 


Leu Glu Ser Ile Gly Leu Gln Gln Tyr Glu Ser Lys Leu Leu Leu Asn 
705                 710                 715                 720 


Gly Phe Asp Asp Val His Phe Leu Gly Ser Asn Val Met Glu Glu Gln 
                725                 730                 735     


Asp Leu Arg Asp Ile Gly Ile Ser Asp Pro Gln His Arg Arg Lys Leu 
            740                 745                 750         


Leu Gln Ala Ala Arg Ser Leu Pro Lys Val Lys Ala Leu Gly Tyr Asp 
        755                 760                 765             


Gly Asn Ser Pro Pro Ser Val Pro Ser Trp Leu Asp Ser Leu Gly Leu 
    770                 775                 780                 


Gln Asp Tyr Val His Ser Phe Leu Ser Ser Gly Tyr Ser Ser Ile Asp 
785                 790                 795                 800 


Thr Val Lys Asn Leu Trp Glu Leu Glu Leu Val Asn Val Leu Lys Val 
                805                 810                 815     


Gln Leu Leu Gly His Arg Lys Arg Ile Ile Ala Ser Leu Ala Asp Arg 
            820                 825                 830         


Pro Tyr Glu Glu Pro Pro Gln Lys Pro Pro Arg Phe Ser Gln Leu Arg 
        835                 840                 845             


Cys Gln Asp Leu Leu Ser Gln Thr Ser Ser Pro Leu Ser Gln Asn Asp 
    850                 855                 860                 


Ser Cys Thr Gly Arg Ser Ala Asp Leu Leu Leu Pro Pro Gly Asp Thr 
865                 870                 875                 880 


Gly Arg Arg Arg His Asp Ser Leu His Asp Pro Ala Ala Pro Ser Arg 
                885                 890                 895     


Ala Glu Arg Phe Arg Ile Gln Glu Glu His Arg Glu Ala Lys Leu Thr 
            900                 905                 910         


Leu Arg Pro Pro Ser Leu Ala Ala Pro Tyr Ala Pro Val Gln Ser Trp 
        915                 920                 925             


Gln His Gln Pro Glu Lys Leu Ile Phe Glu Ser Cys Gly Tyr Glu Ala 
    930                 935                 940                 


Asn Tyr Leu Gly Ser Met Leu Ile Lys Asp Leu Arg Gly Thr Glu Ser 
945                 950                 955                 960 


Thr Gln Asp Ala Cys Ala Lys Met Arg Lys Ser Thr Glu His Met Lys 
                965                 970                 975     


Lys Ile Pro Thr Ile Ile Leu Ser Ile Thr Tyr Lys Gly Val Lys Phe 
            980                 985                 990         


Ile Asp Ala Ser Asn Lys Asn Val  Ile Ala Glu His Glu  Ile Arg Asn 
        995                 1000                 1005             


Ile Ser  Cys Ala Ala Gln Asp  Pro Glu Asp Leu Cys  Thr Phe Ala 
    1010                 1015                 1020             


Tyr Ile  Thr Lys Asp Leu Gln  Thr Ser His His Tyr  Cys His Val 
    1025                 1030                 1035             


Phe Ser  Thr Val Asp Val Asn  Leu Thr Tyr Glu Ile  Ile Leu Thr 
    1040                 1045                 1050             


Leu Gly  Gln Ala Phe Glu Val  Ala Tyr Gln Leu Ala  Leu Gln Ala 
    1055                 1060                 1065             


Gln Lys  Ser Arg Ala Thr Gly  Ala Ser Ala Ala Glu  Met Ile Glu 
    1070                 1075                 1080             


Thr Lys  Ser Ser Lys Pro Val  Pro Lys Pro Arg Val  Gly Val Arg 
    1085                 1090                 1095             


Lys Ser  Ala Leu Glu Pro Pro  Asp Met Asp Gln Asp  Ala Gln Ser 
    1100                 1105                 1110             


His Ala  Ser Val Ser Trp Val  Val Asp Pro Lys Pro  Asp Ser Lys 
    1115                 1120                 1125             


Arg Ser  Leu Ser Thr Asn 
    1130                 


<210>  556
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKS1B__Homo_sapiens__NP_001190995

<400>  556

Met Ala Asn Gly Phe Asp Asn Val Gln Phe Met Gly Ser Asn Val Met 
1               5                   10                  15      


Glu Asp Gln Asp Leu Leu Glu Ile Gly Ile Leu Asn Ser Gly His Arg 
            20                  25                  30          


Gln Arg Ile Leu Gln Ala Ile Gln Leu Leu Pro Lys Met Arg Pro Ile 
        35                  40                  45              


Gly His Asp Gly Tyr His Pro Thr Ser Val Ala Glu Trp Leu Asp Ser 
    50                  55                  60                  


Ile Glu Leu Gly Asp Tyr Thr Lys Ala Phe Leu Ile Asn Gly Tyr Thr 
65                  70                  75                  80  


Ser Met Asp Leu Leu Lys Lys Ile Trp Glu Val Glu Leu Ile Asn Gln 
                85                  90                  95      


Ser Ser Val Cys Glu Ile Trp Thr Asn Gln Asn Ala Gly Phe Pro Phe 
            100                 105                 110         


Ser Ala Ile His Gln Val His Asn Thr Gly Asp Trp Gly Glu Pro Ser 
        115                 120                 125             


Ile Thr Leu Arg Pro Pro Asn Glu Ala Thr Ala Ser Thr Pro Val Gln 
    130                 135                 140                 


Tyr Trp Gln His His Pro Glu Lys Leu Ile Phe Gln Ser Cys Asp Tyr 
145                 150                 155                 160 


Lys Ala Phe Tyr Leu Gly Ser Met Leu Ile Lys Glu Leu Arg Gly Thr 
                165                 170                 175     


Glu Ser Thr Gln Asp Ala Cys Ala Lys Met Arg Ala Asn Cys Gln Lys 
            180                 185                 190         


Ser Thr Glu Gln Met Lys Lys Val Pro Thr Ile Ile Leu Ser Val Ser 
        195                 200                 205             


Tyr Lys Gly Val Lys Phe Ile Asp Ala Thr Asn Lys Asn Ile Ile Ala 
    210                 215                 220                 


Glu His Glu Ile Arg Asn Ile Ser Cys Ala Ala Gln Asp Pro Glu Asp 
225                 230                 235                 240 


Leu Ser Thr Phe Ala Tyr Ile Thr Lys Asp Leu Lys Ser Asn His His 
                245                 250                 255     


Tyr Cys His Val Phe Thr Ala Phe Asp Val Asn Leu Ala Tyr Glu Ile 
            260                 265                 270         


Ile Leu Thr Leu Gly Gln Ala Phe Glu Val Ala Tyr Gln Leu Ala Leu 
        275                 280                 285             


Gln Ala Arg Lys Gly Gly His Ser Ser Thr Leu Pro Glu Ser Phe Glu 
    290                 295                 300                 


Asn Lys Pro Ser Lys Pro Ile Pro Lys Pro Arg Val Ser Ile Arg Lys 
305                 310                 315                 320 


Ser Val Ile Asp Pro Ser Glu Gln Lys Thr Leu Ala Asn Leu Pro Trp 
                325                 330                 335     


Ile Val Glu Pro Gly Gln Glu Ala Lys Arg Gly Ile Asn Thr Lys Tyr 
            340                 345                 350         


Glu Thr Thr Ile Phe 
        355         


<210>  557
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKS4B__Homo_sapiens__NP_665872

<400>  557

Met Ser Thr Arg Tyr His Gln Ala Ala Ser Asp Ser Tyr Leu Glu Leu 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Arg Asp Leu Asn Leu Ser Asp Glu Asp Gly 
            20                  25                  30          


Met Thr Pro Thr Leu Leu Ala Ala Tyr His Gly Asn Leu Glu Ala Leu 
        35                  40                  45              


Glu Ile Ile Cys Ser Arg Gly Gly Asp Pro Asp Arg Cys Asp Ile Trp 
    50                  55                  60                  


Gly Asn Thr Pro Leu His Phe Ala Ala Ser Asn Gly His Ala His Cys 
65                  70                  75                  80  


Val Ser Phe Leu Val Asn Phe Gly Ala Asn Ile Phe Ala Leu Asp Asn 
                85                  90                  95      


Asp Leu Gln Thr Pro Leu Asp Ala Ala Ala Ser Arg Glu Gln Asn Glu 
            100                 105                 110         


Cys Val Ala Leu Leu Asp Lys Ala Ala Thr Ala Gln Asn Ile Met Asn 
        115                 120                 125             


Pro Lys Lys Val Thr Arg Leu Lys Glu Gln Ala Gln Lys Asn Ala Arg 
    130                 135                 140                 


Arg Gln Ile Lys Glu Cys Glu Arg Leu Gln Glu Lys His Gln Asn Lys 
145                 150                 155                 160 


Met Ala His Thr Tyr Ser Lys Glu Glu Ser Gly Thr Leu Ser Ser Ser 
                165                 170                 175     


Lys Gly Thr Phe Ser Arg Ser Ser Pro Ser Asn Ala Ser Ala Pro Gly 
            180                 185                 190         


Thr Phe Gly Ser Leu Ser Lys Gly Ile Lys Asp Thr Phe Lys Ile Lys 
        195                 200                 205             


Phe Lys Lys Asn Lys Asp Thr Ala Glu Gln Val Gly Lys Glu Gly Arg 
    210                 215                 220                 


Ser Gly Gln Arg Asn Val Met Glu Val Phe Arg Glu Glu Glu Glu Asp 
225                 230                 235                 240 


Ser Phe Ser Gly Asp Phe Lys Glu Lys Leu Gln Leu Ser Ala Glu Glu 
                245                 250                 255     


Asp Gly Ser Val His His Glu Ser Ile Leu Asn Arg Pro Gly Leu Gly 
            260                 265                 270         


Ser Ile Val Phe Arg Arg Asn Arg Ile Ser Ser Pro Glu Asp Ile Ser 
        275                 280                 285             


Asp Ser Lys Arg Glu Phe Gly Phe Lys Leu Pro Ser Glu Leu Leu Gln 
    290                 295                 300                 


Arg Gln Gly Ala Ser Glu Ala Asp Glu Gly Ala Ala Asp Glu Glu Gly 
305                 310                 315                 320 


Glu Glu Asn Gly Leu Lys Asp Asp Leu Pro Trp Asp Asp Asp Glu Val 
                325                 330                 335     


Glu Trp Glu Glu Asp Val Val Asp Ala Thr Pro Leu Glu Val Phe Leu 
            340                 345                 350         


Leu Ser Gln His Leu Glu Glu Phe Leu Pro Ile Phe Lys Arg Glu Gln 
        355                 360                 365             


Ile Asp Leu Glu Ala Leu Leu Leu Cys Ser Asp Glu Asp Leu Gln Ser 
    370                 375                 380                 


Ile Gln Met Gln Leu Gly Pro Arg Lys Lys Val Leu Asn Ala Ile Asn 
385                 390                 395                 400 


Arg Arg Lys Gln Val Leu Gln Gln Pro Gly Gln Leu Val Asp Thr Ser 
                405                 410                 415     


Leu 
    


<210>  558
<211>  871
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANKS6__Homo_sapiens__NP_775822

<400>  558

Met Gly Glu Gly Gly Leu Pro Pro Ala Phe Gln Leu Leu Leu Arg Ala 
1               5                   10                  15      


Cys Asp Gln Gly Asp Thr Glu Thr Ala Arg Arg Leu Leu Glu Pro Gly 
            20                  25                  30          


Ala Ala Glu Pro Ala Glu Arg Gly Ala Glu Pro Glu Ala Gly Ala Glu 
        35                  40                  45              


Pro Ala Gly Ala Glu Val Ala Gly Pro Gly Ala Ala Ala Ala Gly Ala 
    50                  55                  60                  


Val Gly Ala Pro Val Pro Val Asp Cys Ser Asp Glu Ala Gly Asn Thr 
65                  70                  75                  80  


Ala Leu Gln Phe Ala Ala Ala Gly Gly His Glu Pro Leu Val Arg Phe 
                85                  90                  95      


Leu Leu Arg Arg Gly Ala Ser Val Asn Ser Arg Asn His Tyr Gly Trp 
            100                 105                 110         


Ser Ala Leu Met Gln Ala Ala Arg Phe Gly His Val Ser Val Ala His 
        115                 120                 125             


Leu Leu Leu Asp His Gly Ala Asp Val Asn Ala Gln Asn Arg Leu Gly 
    130                 135                 140                 


Ala Ser Val Leu Thr Val Ala Ser Arg Gly Gly His Leu Gly Val Val 
145                 150                 155                 160 


Lys Leu Leu Leu Glu Ala Gly Ala Phe Val Asp His His His Pro Ser 
                165                 170                 175     


Gly Glu Gln Leu Gly Leu Gly Gly Ser Arg Asp Glu Pro Leu Asp Ile 
            180                 185                 190         


Thr Ala Leu Met Ala Ala Ile Gln His Gly His Glu Ala Val Val Arg 
        195                 200                 205             


Leu Leu Met Glu Trp Gly Ala Asp Pro Asn His Ala Ala Arg Thr Val 
    210                 215                 220                 


Gly Trp Ser Pro Leu Met Leu Ala Ala Leu Thr Gly Arg Leu Gly Val 
225                 230                 235                 240 


Ala Gln Gln Leu Val Glu Lys Gly Ala Asn Pro Asp His Leu Ser Val 
                245                 250                 255     


Leu Glu Lys Thr Ala Phe Glu Val Ala Leu Asp Cys Lys His Arg Asp 
            260                 265                 270         


Leu Val Asp Tyr Leu Asp Pro Leu Thr Thr Val Arg Pro Lys Thr Asp 
        275                 280                 285             


Glu Glu Lys Arg Arg Pro Asp Ile Phe His Ala Leu Lys Met Gly Asn 
    290                 295                 300                 


Phe Gln Leu Val Lys Glu Ile Ala Asp Glu Asp Pro Ser His Val Asn 
305                 310                 315                 320 


Leu Val Asn Gly Asp Gly Ala Thr Pro Leu Met Leu Ala Ala Val Thr 
                325                 330                 335     


Gly Gln Leu Ala Leu Val Gln Leu Leu Val Glu Arg His Ala Asp Val 
            340                 345                 350         


Asp Lys Gln Asp Ser Val His Gly Trp Thr Ala Leu Met Gln Ala Thr 
        355                 360                 365             


Tyr His Gly Asn Lys Glu Ile Val Lys Tyr Leu Leu Asn Gln Gly Ala 
    370                 375                 380                 


Asp Val Thr Leu Arg Ala Lys Asn Gly Tyr Thr Ala Phe Asp Leu Val 
385                 390                 395                 400 


Met Leu Leu Asn Asp Pro Asp Thr Glu Leu Val Arg Leu Leu Ala Ser 
                405                 410                 415     


Val Cys Met Gln Val Asn Lys Asp Lys Gly Arg Pro Ser His Gln Pro 
            420                 425                 430         


Pro Leu Pro His Ser Lys Val Arg Gln Pro Trp Ser Ile Pro Val Leu 
        435                 440                 445             


Pro Asp Asp Lys Gly Gly Leu Lys Ser Trp Trp Asn Arg Met Ser Asn 
    450                 455                 460                 


Arg Phe Arg Lys Leu Lys Leu Met Gln Thr Leu Pro Arg Gly Leu Ser 
465                 470                 475                 480 


Ser Asn Gln Pro Leu Pro Phe Ser Asp Glu Pro Glu Pro Ala Leu Asp 
                485                 490                 495     


Ser Thr Met Arg Ala Ala Pro Gln Asp Lys Thr Ser Arg Ser Ala Leu 
            500                 505                 510         


Pro Asp Ala Ala Pro Val Thr Lys Asp Asn Gly Pro Gly Ser Thr Arg 
        515                 520                 525             


Gly Glu Lys Glu Asp Thr Leu Leu Thr Thr Met Leu Arg Asn Gly Ala 
    530                 535                 540                 


Pro Leu Thr Arg Leu Pro Ser Asp Lys Leu Lys Ala Val Ile Pro Pro 
545                 550                 555                 560 


Phe Leu Pro Pro Ser Ser Phe Glu Leu Trp Ser Ser Asp Arg Ser Arg 
                565                 570                 575     


Thr Arg His Asn Gly Lys Ala Asp Pro Met Lys Thr Ala Leu Pro Gln 
            580                 585                 590         


Arg Ala Ser Arg Gly His Pro Val Gly Gly Gly Gly Thr Asp Thr Thr 
        595                 600                 605             


Pro Val Arg Pro Val Lys Phe Pro Ser Leu Pro Arg Ser Pro Ala Ser 
    610                 615                 620                 


Ser Ala Asn Ser Gly Asn Phe Asn His Ser Pro His Ser Ser Gly Gly 
625                 630                 635                 640 


Ser Ser Gly Val Gly Val Ser Arg His Gly Gly Glu Leu Leu Asn Arg 
                645                 650                 655     


Ser Gly Gly Ser Ile Asp Asn Val Leu Ser Gln Ile Ala Ala Gln Arg 
            660                 665                 670         


Lys Lys Ala Ala Gly Leu Leu Glu Gln Lys Pro Ser His Arg Ser Ser 
        675                 680                 685             


Pro Val Gly Pro Ala Pro Gly Ser Ser Pro Ser Glu Leu Pro Ala Ser 
    690                 695                 700                 


Pro Ala Gly Gly Ser Ala Pro Val Gly Lys Lys Leu Glu Thr Ser Lys 
705                 710                 715                 720 


Arg Pro Pro Ser Gly Thr Ser Thr Thr Ser Lys Ser Thr Ser Pro Thr 
                725                 730                 735     


Leu Thr Pro Ser Pro Ser Pro Lys Gly His Thr Ala Glu Ser Ser Val 
            740                 745                 750         


Ser Ser Ser Ser Ser His Arg Gln Ser Lys Ser Ser Gly Gly Ser Ser 
        755                 760                 765             


Ser Gly Thr Ile Thr Asp Glu Asp Glu Leu Thr Gly Ile Leu Lys Lys 
    770                 775                 780                 


Leu Ser Leu Glu Lys Tyr Gln Pro Ile Phe Glu Glu Gln Glu Val Asp 
785                 790                 795                 800 


Met Glu Ala Phe Leu Thr Leu Thr Asp Gly Asp Leu Lys Glu Leu Gly 
                805                 810                 815     


Ile Lys Thr Asp Gly Ser Arg Gln Gln Ile Leu Ala Ala Ile Ser Glu 
            820                 825                 830         


Leu Asn Ala Gly Lys Gly Arg Glu Arg Gln Ile Leu Gln Glu Thr Ile 
        835                 840                 845             


His Asn Phe His Ser Ser Phe Glu Ser Ser Ala Ser Asn Thr Arg Ala 
    850                 855                 860                 


Pro Gly Asn Ser Pro Cys Ala 
865                 870     


<210>  559
<211>  1087
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANLN__Homo_sapiens__NP_001271230

<400>  559

Met Asp Pro Phe Thr Glu Lys Leu Leu Glu Arg Thr Arg Ala Arg Arg 
1               5                   10                  15      


Glu Asn Leu Gln Arg Lys Met Ala Glu Arg Pro Thr Ala Ala Pro Arg 
            20                  25                  30          


Ser Met Thr His Ala Lys Arg Ala Arg Gln Pro Leu Ser Glu Ala Ser 
        35                  40                  45              


Asn Gln Gln Pro Leu Ser Gly Gly Glu Glu Lys Ser Cys Thr Lys Pro 
    50                  55                  60                  


Ser Pro Ser Lys Lys Arg Cys Ser Asp Asn Thr Glu Val Glu Val Ser 
65                  70                  75                  80  


Asn Leu Glu Asn Lys Gln Pro Val Glu Ser Thr Ser Ala Lys Ser Cys 
                85                  90                  95      


Ser Pro Ser Pro Val Ser Pro Gln Val Gln Pro Gln Ala Ala Asp Thr 
            100                 105                 110         


Ile Ser Asp Ser Val Ala Val Pro Ala Ser Leu Leu Gly Met Arg Arg 
        115                 120                 125             


Gly Leu Asn Ser Arg Leu Glu Ala Thr Ala Ala Ser Ser Val Lys Thr 
    130                 135                 140                 


Arg Met Gln Lys Leu Ala Glu Gln Arg Arg Arg Trp Asp Asn Asp Asp 
145                 150                 155                 160 


Met Thr Asp Asp Ile Pro Glu Ser Ser Leu Phe Ser Pro Met Pro Ser 
                165                 170                 175     


Glu Glu Lys Ala Ala Ser Pro Pro Arg Pro Leu Leu Ser Asn Ala Ser 
            180                 185                 190         


Ala Thr Pro Val Gly Arg Arg Gly Arg Leu Ala Asn Leu Ala Ala Thr 
        195                 200                 205             


Ile Cys Ser Trp Glu Asp Asp Val Asn His Ser Phe Ala Lys Gln Asn 
    210                 215                 220                 


Ser Val Gln Glu Gln Pro Gly Thr Ala Cys Leu Ser Lys Phe Ser Ser 
225                 230                 235                 240 


Ala Ser Gly Ala Ser Ala Arg Ile Asn Ser Ser Ser Val Lys Gln Glu 
                245                 250                 255     


Ala Thr Phe Cys Ser Gln Arg Asp Gly Asp Ala Ser Leu Asn Lys Ala 
            260                 265                 270         


Leu Ser Ser Ser Ala Asp Asp Ala Ser Leu Val Asn Ala Ser Ile Ser 
        275                 280                 285             


Ser Ser Val Lys Ala Thr Ser Pro Val Lys Ser Thr Thr Ser Ile Thr 
    290                 295                 300                 


Asp Ala Lys Ser Cys Glu Gly Gln Asn Pro Glu Leu Leu Pro Lys Thr 
305                 310                 315                 320 


Pro Ile Ser Pro Leu Lys Thr Gly Val Ser Lys Pro Ile Val Lys Ser 
                325                 330                 335     


Thr Leu Ser Gln Thr Val Pro Ser Lys Gly Glu Leu Ser Arg Glu Ile 
            340                 345                 350         


Cys Leu Gln Ser Gln Ser Lys Asp Lys Ser Thr Thr Pro Gly Gly Thr 
        355                 360                 365             


Gly Ile Lys Pro Phe Leu Glu Arg Phe Gly Glu Arg Cys Gln Glu His 
    370                 375                 380                 


Ser Lys Glu Ser Pro Ala Arg Ser Thr Pro His Arg Thr Pro Ile Ile 
385                 390                 395                 400 


Thr Pro Asn Thr Lys Ala Ile Gln Glu Arg Leu Phe Lys Gln Asp Thr 
                405                 410                 415     


Ser Ser Ser Thr Thr His Leu Ala Gln Gln Leu Lys Gln Glu Arg Gln 
            420                 425                 430         


Lys Glu Leu Ala Cys Leu Arg Gly Arg Phe Asp Lys Gly Asn Ile Trp 
        435                 440                 445             


Ser Ala Glu Lys Gly Gly Asn Ser Lys Ser Lys Gln Leu Glu Thr Lys 
    450                 455                 460                 


Gln Glu Thr His Cys Gln Ser Thr Pro Leu Lys Lys His Gln Gly Val 
465                 470                 475                 480 


Ser Lys Thr Gln Ser Leu Pro Val Thr Glu Lys Val Thr Glu Asn Gln 
                485                 490                 495     


Ile Pro Ala Lys Asn Ser Ser Thr Glu Pro Lys Glu Val Ile Arg Glu 
            500                 505                 510         


Ile Glu Met Ser Val Asp Asp Asp Asp Ile Asn Ser Ser Lys Val Ile 
        515                 520                 525             


Asn Asp Leu Phe Ser Asp Val Leu Glu Glu Gly Glu Leu Asp Met Glu 
    530                 535                 540                 


Lys Ser Gln Glu Glu Met Asp Gln Ala Leu Ala Glu Ser Ser Glu Glu 
545                 550                 555                 560 


Gln Glu Asp Ala Leu Asn Ile Ser Ser Met Ser Leu Leu Ala Pro Leu 
                565                 570                 575     


Ala Gln Thr Val Gly Val Val Ser Pro Glu Ser Leu Val Ser Thr Pro 
            580                 585                 590         


Arg Leu Glu Leu Lys Asp Thr Ser Arg Ser Asp Glu Ser Pro Lys Pro 
        595                 600                 605             


Gly Lys Phe Gln Arg Thr Arg Val Pro Arg Ala Glu Ser Gly Asp Ser 
    610                 615                 620                 


Leu Gly Ser Glu Asp Arg Asp Leu Leu Tyr Ser Ile Asp Ala Tyr Arg 
625                 630                 635                 640 


Ser Gln Arg Phe Lys Glu Thr Glu Arg Pro Ser Ile Lys Gln Val Ile 
                645                 650                 655     


Val Arg Lys Glu Asp Val Thr Ser Lys Leu Asp Glu Lys Asn Asn Ala 
            660                 665                 670         


Phe Pro Cys Gln Val Asn Ile Lys Gln Lys Met Gln Glu Leu Asn Asn 
        675                 680                 685             


Glu Ile Asn Met Gln Gln Thr Val Ile Tyr Gln Ala Ser Gln Ala Leu 
    690                 695                 700                 


Asn Cys Cys Val Asp Glu Glu His Gly Lys Gly Ser Leu Glu Glu Ala 
705                 710                 715                 720 


Glu Ala Glu Arg Leu Leu Leu Ile Ala Thr Gly Lys Arg Thr Leu Leu 
                725                 730                 735     


Ile Asp Glu Leu Asn Lys Leu Lys Asn Glu Gly Pro Gln Arg Lys Asn 
            740                 745                 750         


Lys Ala Ser Pro Gln Ser Glu Phe Met Pro Ser Lys Gly Ser Val Thr 
        755                 760                 765             


Leu Ser Glu Ile Arg Leu Pro Leu Lys Ala Asp Phe Val Cys Ser Thr 
    770                 775                 780                 


Val Gln Lys Pro Asp Ala Ala Asn Tyr Tyr Tyr Leu Ile Ile Leu Lys 
785                 790                 795                 800 


Ala Gly Ala Glu Asn Met Val Ala Thr Pro Leu Ala Ser Thr Ser Asn 
                805                 810                 815     


Ser Leu Asn Gly Asp Ala Leu Thr Phe Thr Thr Thr Phe Thr Leu Gln 
            820                 825                 830         


Asp Val Ser Asn Asp Phe Glu Ile Asn Ile Glu Val Tyr Ser Leu Val 
        835                 840                 845             


Gln Lys Lys Asp Pro Ser Gly Leu Asp Lys Lys Lys Lys Thr Ser Lys 
    850                 855                 860                 


Ser Lys Ala Ile Thr Pro Lys Arg Leu Leu Thr Ser Ile Thr Thr Lys 
865                 870                 875                 880 


Ser Asn Ile His Ser Ser Val Met Ala Ser Pro Gly Gly Leu Ser Ala 
                885                 890                 895     


Val Arg Thr Ser Asn Phe Ala Leu Val Gly Ser Tyr Thr Leu Ser Leu 
            900                 905                 910         


Ser Ser Val Gly Asn Thr Lys Phe Val Leu Asp Lys Val Pro Phe Leu 
        915                 920                 925             


Ser Ser Leu Glu Gly His Ile Tyr Leu Lys Ile Lys Cys Gln Val Asn 
    930                 935                 940                 


Ser Ser Val Glu Glu Arg Gly Phe Leu Thr Ile Phe Glu Asp Val Ser 
945                 950                 955                 960 


Gly Phe Gly Ala Trp His Arg Arg Trp Cys Val Leu Ser Gly Asn Cys 
                965                 970                 975     


Ile Ser Tyr Trp Thr Tyr Pro Asp Asp Glu Lys Arg Lys Asn Pro Ile 
            980                 985                 990         


Gly Arg Ile Asn Leu Ala Asn Cys  Thr Ser Arg Gln Ile  Glu Pro Ala 
        995                 1000                 1005             


Asn Arg  Glu Phe Cys Ala Arg  Arg Asn Thr Phe Glu  Leu Ile Thr 
    1010                 1015                 1020             


Val Arg  Pro Gln Arg Glu Asp  Asp Arg Glu Thr Leu  Val Ser Gln 
    1025                 1030                 1035             


Cys Arg  Asp Thr Leu Cys Val  Thr Lys Asn Trp Leu  Ser Ala Asp 
    1040                 1045                 1050             


Thr Lys  Glu Glu Arg Asp Leu  Trp Met Gln Lys Leu  Asn Gln Val 
    1055                 1060                 1065             


Leu Val  Asp Ile Arg Leu Trp  Gln Pro Asp Ala Cys  Tyr Lys Pro 
    1070                 1075                 1080             


Ile Gly  Lys Pro 
    1085         


<210>  560
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO10__Homo_sapiens__NP_001191760

<400>  560

Met Lys Val Thr Leu Ser Ala Leu Asp Thr Ser Glu Ser Ser Phe Thr 
1               5                   10                  15      


Pro Leu Val Val Ile Glu Leu Ala Gln Asp Val Lys Glu Glu Thr Lys 
            20                  25                  30          


Glu Trp Leu Lys Asn Arg Ile Ile Ala Lys Lys Lys Asp Gly Gly Ala 
        35                  40                  45              


Gln Leu Leu Phe Arg Pro Leu Leu Asn Lys Tyr Glu Gln Glu Thr Leu 
    50                  55                  60                  


Glu Asn Gln Asn Leu Tyr Leu Val Gly Ala Ser Lys Ile Arg Met Leu 
65                  70                  75                  80  


Leu Gly Ala Glu Ala Val Gly Leu Val Lys Glu Cys Asn Asp Asn Thr 
                85                  90                  95      


Met Arg Ala Phe Thr Tyr Arg Thr Arg Gln Asn Phe Lys Gly Phe Asp 
            100                 105                 110         


Asp Asn Asn Asp Asp Phe Leu Thr Met Ala Glu Cys Gln Phe Ile Ile 
        115                 120                 125             


Lys His Glu Leu Glu Asn Leu Arg Ala Lys Asp Glu Lys Met Ile Pro 
    130                 135                 140                 


Gly Tyr Pro Gln Ala Lys Leu Tyr Pro Gly Lys Ser Leu Leu Arg Arg 
145                 150                 155                 160 


Leu Leu Thr Ser Gly Ile Val Ile Gln Val Phe Pro Leu His Asp Ser 
                165                 170                 175     


Glu Ala Leu Lys Lys Leu Glu Asp Thr Trp Tyr Thr Arg Phe Ala Leu 
            180                 185                 190         


Lys Tyr Gln Pro Ile Asp Ser Ile Arg Gly Tyr Phe Gly Glu Thr Ile 
        195                 200                 205             


Ala Leu Tyr Phe Gly Phe Leu Glu Tyr Phe Thr Phe Ala Leu Ile Pro 
    210                 215                 220                 


Met Ala Val Ile Gly Leu Pro Tyr Tyr Leu Phe Val Trp Glu Asp Tyr 
225                 230                 235                 240 


Asp Lys Tyr Val Ile Phe Ala Ser Phe Asn Leu Ile Trp Ser Thr Val 
                245                 250                 255     


Ile Leu Glu Leu Trp Lys Arg Gly Cys Ala Asn Met Thr Tyr Arg Trp 
            260                 265                 270         


Gly Thr Leu Leu Met Lys Arg Lys Phe Glu Glu Pro Arg Pro Gly Phe 
        275                 280                 285             


His Gly Val Leu Gly Ile Asn Ser Ile Thr Gly Lys Glu Glu Pro Leu 
    290                 295                 300                 


Tyr Pro Ser Tyr Lys Arg Gln Leu Arg Ile Tyr Leu Val Ser Leu Pro 
305                 310                 315                 320 


Phe Val Cys Leu Cys Leu Tyr Phe Ser Leu Tyr Val Met Met Ile Tyr 
                325                 330                 335     


Phe Asp Met Glu Val Trp Ala Leu Gly Leu His Glu Asn Ser Gly Ser 
            340                 345                 350         


Glu Trp Thr Ser Val Leu Leu Tyr Val Pro Ser Ile Ile Tyr Ala Ile 
        355                 360                 365             


Val Ile Glu Ile Met Asn Arg Leu Tyr Arg Tyr Ala Ala Glu Phe Leu 
    370                 375                 380                 


Thr Ser Trp Glu Asn His Arg Leu Glu Ser Ala Tyr Gln Asn His Leu 
385                 390                 395                 400 


Ile Leu Lys Val Leu Val Phe Asn Phe Leu Asn Cys Phe Ala Ser Leu 
                405                 410                 415     


Phe Tyr Ile Ala Phe Val Leu Lys Asp Met Lys Leu Leu Arg Gln Ser 
            420                 425                 430         


Leu Ala Thr Leu Leu Ile Thr Ser Gln Ile Leu Asn Gln Ile Met Glu 
        435                 440                 445             


Ser Phe Leu Pro Tyr Trp Leu Gln Arg Lys His Gly Val Arg Val Lys 
    450                 455                 460                 


Arg Lys Val Gln Ala Leu Lys Ala Asp Ile Asp Ala Thr Leu Tyr Glu 
465                 470                 475                 480 


Gln Val Ile Leu Glu Lys Glu Met Gly Thr Tyr Leu Gly Thr Phe Asp 
                485                 490                 495     


Asp Tyr Leu Glu Leu Phe Leu Gln Phe Gly Tyr Val Ser Leu Phe Ser 
            500                 505                 510         


Cys Val Tyr Pro Leu Ala Ala Ala Phe Ala Val Leu Asn Asn Phe Thr 
        515                 520                 525             


Glu Val Asn Ser Asp Ala Leu Lys Met Cys Arg Val Phe Lys Arg Pro 
    530                 535                 540                 


Phe Ser Glu Pro Ser Ala Asn Ile Gly Val Trp Gln Leu Ala Phe Glu 
545                 550                 555                 560 


Thr Met Ser Val Ile Ser Val Val Thr Asn Cys Ala Leu Ile Gly Met 
                565                 570                 575     


Ser Pro Gln Val Asn Ala Val Phe Pro Glu Ser Lys Ala Asp Leu Ile 
            580                 585                 590         


Leu Ile Val Val Ala Val Glu Ala Ala Ser Cys Lys Leu Val Ser Leu 
        595                 600                 605             


Pro Arg Tyr Ser Trp Ser Thr Asn Ser Val Pro Gly Thr Val Ile Gly 
    610                 615                 620                 


Pro Gly Val 
625         


<210>  561
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO1__Homo_sapiens__NP_060513

<400>  561

Met Arg Val Asn Glu Lys Tyr Ser Thr Leu Pro Ala Glu Asp Arg Ser 
1               5                   10                  15      


Val His Ile Ile Asn Ile Cys Ala Ile Glu Asp Ile Gly Tyr Leu Pro 
            20                  25                  30          


Ser Glu Gly Thr Leu Leu Asn Ser Leu Ser Val Asp Pro Asp Ala Glu 
        35                  40                  45              


Cys Lys Tyr Gly Leu Tyr Phe Arg Asp Gly Arg Arg Lys Val Asp Tyr 
    50                  55                  60                  


Ile Leu Val Tyr His His Lys Arg Pro Ser Gly Asn Arg Thr Leu Val 
65                  70                  75                  80  


Arg Arg Val Gln His Ser Asp Thr Pro Ser Gly Ala Arg Ser Val Lys 
                85                  90                  95      


Gln Asp His Pro Leu Pro Gly Lys Gly Ala Ser Leu Asp Ala Gly Ser 
            100                 105                 110         


Gly Glu Pro Pro Met Asp Tyr His Glu Asp Asp Lys Arg Phe Arg Arg 
        115                 120                 125             


Glu Glu Tyr Glu Gly Asn Leu Leu Glu Ala Gly Leu Glu Leu Glu Arg 
    130                 135                 140                 


Asp Glu Asp Thr Lys Ile His Gly Val Gly Phe Val Lys Ile His Ala 
145                 150                 155                 160 


Pro Trp Asn Val Leu Cys Arg Glu Ala Glu Phe Leu Lys Leu Lys Met 
                165                 170                 175     


Pro Thr Lys Lys Met Tyr His Ile Asn Glu Thr Arg Gly Leu Leu Lys 
            180                 185                 190         


Lys Ile Asn Ser Val Leu Gln Lys Ile Thr Asp Pro Ile Gln Pro Lys 
        195                 200                 205             


Val Ala Glu His Arg Pro Gln Thr Met Lys Arg Leu Ser Tyr Pro Phe 
    210                 215                 220                 


Ser Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp Lys Asp Ser Phe 
225                 230                 235                 240 


Phe Asp Ser Lys Thr Arg Ser Thr Ile Val Tyr Glu Ile Leu Lys Arg 
                245                 250                 255     


Thr Thr Cys Thr Lys Ala Lys Tyr Ser Met Gly Ile Thr Ser Leu Leu 
            260                 265                 270         


Ala Asn Gly Val Tyr Ala Ala Ala Tyr Pro Leu His Asp Gly Asp Tyr 
        275                 280                 285             


Asn Gly Glu Asn Val Glu Phe Asn Asp Arg Lys Leu Leu Tyr Glu Glu 
    290                 295                 300                 


Trp Ala Arg Tyr Gly Val Phe Tyr Lys Tyr Gln Pro Ile Asp Leu Val 
305                 310                 315                 320 


Arg Lys Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
                325                 330                 335     


Val Tyr Thr Gln Met Leu Ile Pro Ala Ser Ile Val Gly Ile Ile Val 
            340                 345                 350         


Phe Leu Tyr Gly Cys Ala Thr Met Asp Glu Asn Ile Pro Ser Met Glu 
        355                 360                 365             


Met Cys Asp Gln Arg His Asn Ile Thr Met Cys Pro Leu Cys Asp Lys 
    370                 375                 380                 


Thr Cys Ser Tyr Trp Lys Met Ser Ser Ala Cys Ala Thr Ala Arg Ala 
385                 390                 395                 400 


Ser His Leu Phe Asp Asn Pro Ala Thr Val Phe Phe Ser Val Phe Met 
                405                 410                 415     


Ala Leu Trp Ala Ala Thr Phe Met Glu His Trp Lys Arg Lys Gln Met 
            420                 425                 430         


Arg Leu Asn Tyr Arg Trp Asp Leu Thr Gly Phe Glu Glu Glu Glu Glu 
        435                 440                 445             


Ala Val Lys Asp His Pro Arg Ala Glu Tyr Glu Ala Arg Val Leu Glu 
    450                 455                 460                 


Lys Ser Leu Lys Lys Glu Ser Arg Asn Lys Glu Lys Arg Arg His Ile 
465                 470                 475                 480 


Pro Glu Glu Ser Thr Asn Lys Trp Lys Gln Arg Val Lys Thr Ala Met 
                485                 490                 495     


Ala Gly Val Lys Leu Thr Asp Lys Val Lys Leu Thr Trp Arg Asp Arg 
            500                 505                 510         


Phe Pro Ala Tyr Leu Thr Asn Leu Val Ser Ile Ile Phe Met Ile Ala 
        515                 520                 525             


Val Thr Phe Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met 
    530                 535                 540                 


Ala Ala Ala Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile 
545                 550                 555                 560 


Arg Val Thr Val Thr Ala Thr Ala Val Ile Ile Asn Leu Val Val Ile 
                565                 570                 575     


Ile Leu Leu Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Thr Lys 
            580                 585                 590         


Ile Glu Val Pro Lys Thr Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe 
        595                 600                 605             


Lys Ala Phe Leu Leu Lys Phe Val Asn Ser Tyr Thr Pro Ile Phe Tyr 
    610                 615                 620                 


Val Ala Phe Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val 
625                 630                 635                 640 


Tyr Ile Phe Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys 
                645                 650                 655     


Leu Met Glu Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln 
            660                 665                 670         


Leu Ile Gln Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys 
        675                 680                 685             


Leu Ile Arg Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu 
    690                 695                 700                 


Glu Cys Val Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu 
705                 710                 715                 720 


Pro Phe Ala Gly Leu Thr Pro Glu Tyr Met Glu Met Ile Ile Gln Phe 
                725                 730                 735     


Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe 
            740                 745                 750         


Ala Leu Leu Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe 
        755                 760                 765             


Val Thr Glu Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly 
    770                 775                 780                 


Ile Trp Tyr Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile 
785                 790                 795                 800 


Asn Ala Phe Val Ile Ser Phe Thr Ser Asp Phe Ile Pro Arg Leu Val 
                805                 810                 815     


Tyr Leu Tyr Met Tyr Ser Lys Asn Gly Thr Met His Gly Phe Val Asn 
            820                 825                 830         


His Thr Leu Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Thr Ala 
        835                 840                 845             


Pro Asn Asp Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr 
    850                 855                 860                 


Lys Asp Tyr Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser 
865                 870                 875                 880 


Lys Asp Phe Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val 
                885                 890                 895     


Phe Gln Asn Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile 
            900                 905                 910         


Pro Asp Ile Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val 
        915                 920                 925             


Leu Met Val Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu 
    930                 935                 940                 


Leu Glu Thr Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys 
945                 950                 955                 960 


Asn His His Asn Thr Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala 
                965                 970                 975     


Pro Ser His Ala Tyr His Gly Gly Val Leu 
            980                 985     


<210>  562
<211>  1003
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO2__Homo_sapiens__NP_001265525

<400>  562

Met Ala Thr Pro Gly Pro Arg Asp Ile Pro Leu Leu Pro Gly Ser Pro 
1               5                   10                  15      


Arg Arg Leu Ser Pro Gln Ala Gly Ser Arg Gly Gly Gln Gly Pro Lys 
            20                  25                  30          


His Gly Gln Gln Cys Leu Lys Met Pro Gly Pro Arg Ala Pro Gly Leu 
        35                  40                  45              


Gln Gly Gly Ser Asn Arg Asp Pro Gly Gln Pro Cys Gly Gly Glu Ser 
    50                  55                  60                  


Thr Arg Ser Ser Ser Val Ile Asn Asn Tyr Leu Asp Ala Asn Glu Pro 
65                  70                  75                  80  


Val Ser Leu Glu Ala Arg Leu Ser Arg Met His Phe His Asp Ser Gln 
                85                  90                  95      


Arg Lys Val Asp Tyr Val Leu Ala Tyr His Tyr Arg Lys Arg Gly Val 
            100                 105                 110         


His Leu Ala Gln Gly Phe Pro Gly His Ser Leu Ala Ile Val Ser Asn 
        115                 120                 125             


Gly Glu Thr Gly Lys Glu Pro His Ala Gly Gly Pro Gly Asp Ile Glu 
    130                 135                 140                 


Leu Gly Pro Leu Asp Ala Leu Glu Glu Glu Arg Lys Glu Gln Arg Glu 
145                 150                 155                 160 


Glu Phe Glu His Asn Leu Met Glu Ala Gly Leu Glu Leu Glu Lys Asp 
                165                 170                 175     


Leu Glu Asn Lys Ser Gln Gly Ser Ile Phe Val Arg Ile His Ala Pro 
            180                 185                 190         


Trp Gln Val Leu Ala Arg Glu Ala Glu Phe Leu Lys Ile Lys Val Pro 
        195                 200                 205             


Thr Lys Lys Glu Met Tyr Glu Ile Lys Ala Gly Gly Ser Ile Ala Lys 
    210                 215                 220                 


Lys Phe Ser Ala Ala Leu Gln Lys Leu Ser Ser His Leu Gln Pro Arg 
225                 230                 235                 240 


Val Pro Glu His Ser Asn Asn Lys Met Lys Asn Leu Ser Tyr Pro Phe 
                245                 250                 255     


Ser Arg Glu Lys Met Tyr Leu Tyr Asn Ile Gln Glu Lys Asp Thr Phe 
            260                 265                 270         


Phe Asp Asn Ala Thr Arg Ser Arg Ile Val His Glu Ile Leu Lys Arg 
        275                 280                 285             


Thr Ala Cys Ser Arg Ala Asn Asn Thr Met Gly Ile Asn Ser Leu Ile 
    290                 295                 300                 


Ala Asn Asn Ile Tyr Glu Ala Ala Tyr Pro Leu His Asp Gly Glu Tyr 
305                 310                 315                 320 


Asp Ser Pro Glu Asp Asp Met Asn Asp Arg Lys Leu Leu Tyr Gln Glu 
                325                 330                 335     


Trp Ala Arg Tyr Gly Val Phe Tyr Lys Phe Gln Pro Ile Asp Leu Ile 
            340                 345                 350         


Arg Lys Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
        355                 360                 365             


Leu Tyr Thr Ser Phe Leu Ile Pro Ser Ser Val Ile Gly Val Ile Val 
    370                 375                 380                 


Phe Leu Tyr Gly Cys Ala Thr Ile Glu Glu Asp Ile Pro Ser Arg Glu 
385                 390                 395                 400 


Met Cys Asp Gln Gln Asn Ala Phe Thr Met Cys Pro Leu Cys Asp Lys 
                405                 410                 415     


Ser Cys Asp Tyr Trp Asn Leu Ser Ser Ala Cys Gly Thr Ala Gln Ala 
            420                 425                 430         


Ser His Leu Phe Asp Asn Pro Ala Thr Val Phe Phe Ser Ile Phe Met 
        435                 440                 445             


Ala Leu Trp Ala Thr Met Phe Leu Glu Asn Trp Lys Arg Leu Gln Met 
    450                 455                 460                 


Arg Leu Gly Tyr Phe Trp Asp Leu Thr Gly Ile Glu Glu Glu Glu Glu 
465                 470                 475                 480 


Arg Ala Gln Glu His Ser Arg Pro Glu Tyr Glu Thr Lys Val Arg Glu 
                485                 490                 495     


Lys Met Leu Lys Glu Ser Asn Gln Ser Ala Val Gln Lys Leu Glu Thr 
            500                 505                 510         


Asn Thr Thr Glu Cys Gly Asp Glu Asp Asp Glu Asp Lys Leu Thr Trp 
        515                 520                 525             


Lys Asp Arg Phe Pro Gly Tyr Leu Met Asn Phe Ala Ser Ile Leu Phe 
    530                 535                 540                 


Met Ile Ala Leu Thr Phe Ser Ile Val Phe Gly Val Ile Val Tyr Arg 
545                 550                 555                 560 


Ile Thr Thr Ala Ala Ala Leu Ser Leu Asn Lys Ala Thr Arg Ser Asn 
                565                 570                 575     


Val Arg Val Thr Val Thr Ala Thr Ala Val Ile Ile Asn Leu Val Val 
            580                 585                 590         


Ile Leu Ile Leu Asp Glu Ile Tyr Gly Ala Val Ala Lys Trp Leu Thr 
        595                 600                 605             


Lys Ile Glu Val Pro Lys Thr Glu Gln Thr Phe Glu Glu Arg Leu Ile 
    610                 615                 620                 


Leu Lys Ala Phe Leu Leu Lys Phe Val Asn Ala Tyr Ser Pro Ile Phe 
625                 630                 635                 640 


Tyr Val Ala Phe Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Ser Tyr 
                645                 650                 655     


Val Tyr Val Phe Asp Gly Tyr Arg Met Glu Glu Cys Ala Pro Gly Gly 
            660                 665                 670         


Cys Leu Met Glu Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys 
        675                 680                 685             


Gln Leu Ile Gln Asn Asn Ile Phe Glu Ile Gly Val Pro Lys Leu Lys 
    690                 695                 700                 


Lys Leu Phe Arg Lys Leu Lys Asp Glu Thr Glu Ala Gly Glu Thr Asp 
705                 710                 715                 720 


Ser Ala His Ser Lys His Pro Glu Gln Trp Asp Leu Asp Tyr Ser Leu 
                725                 730                 735     


Glu Pro Tyr Thr Gly Leu Thr Pro Glu Tyr Met Glu Met Ile Ile Gln 
            740                 745                 750         


Phe Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Val 
        755                 760                 765             


Phe Ala Leu Leu Asn Asn Val Ile Glu Val Arg Leu Asp Ala Lys Lys 
    770                 775                 780                 


Phe Val Thr Glu Leu Arg Arg Pro Asp Ala Val Arg Thr Lys Asp Ile 
785                 790                 795                 800 


Gly Ile Trp Phe Asp Ile Leu Ser Gly Ile Gly Lys Phe Ser Val Ile 
                805                 810                 815     


Ser Asn Ala Phe Val Ile Ala Ile Thr Ser Asp Phe Ile Pro Arg Leu 
            820                 825                 830         


Val Tyr Gln Tyr Ser Tyr Ser His Asn Gly Thr Leu His Gly Phe Val 
        835                 840                 845             


Asn His Thr Leu Ser Phe Phe Asn Val Ser Gln Leu Lys Glu Gly Thr 
    850                 855                 860                 


Gln Pro Glu Asn Ser Gln Phe Asp Gln Glu Val Gln Phe Cys Arg Phe 
865                 870                 875                 880 


Lys Asp Tyr Arg Glu Pro Pro Trp Ala Pro Asn Pro Tyr Glu Phe Ser 
                885                 890                 895     


Lys Gln Tyr Trp Phe Ile Leu Ser Ala Arg Leu Ala Phe Val Ile Ile 
            900                 905                 910         


Phe Gln Asn Leu Val Met Phe Leu Ser Val Leu Val Asp Trp Met Ile 
        915                 920                 925             


Pro Asp Ile Pro Thr Asp Ile Ser Asp Gln Ile Lys Lys Glu Lys Ser 
    930                 935                 940                 


Leu Leu Val Asp Phe Phe Leu Lys Glu Glu His Glu Lys Leu Lys Leu 
945                 950                 955                 960 


Met Asp Glu Pro Ala Leu Arg Ser Pro Gly Gly Gly Asp Arg Ser Arg 
                965                 970                 975     


Ser Arg Ala Ala Ser Ser Ala Pro Ser Gly Gln Ser Gln Leu Gly Ser 
            980                 985                 990         


Met Met Ser Ser Gly Ser Gln His  Thr Asn Val 
        995                 1000             


<210>  563
<211>  981
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO3__Homo_sapiens__NP_113606

<400>  563

Met Val His His Ser Gly Ser Ile Gln Ser Phe Lys Gln Gln Lys Gly 
1               5                   10                  15      


Met Asn Ile Ser Lys Ser Glu Ile Thr Lys Glu Thr Ser Leu Lys Pro 
            20                  25                  30          


Ser Arg Arg Ser Leu Pro Cys Leu Ala Gln Ser Tyr Ala Tyr Ser Lys 
        35                  40                  45              


Ser Leu Ser Gln Ser Thr Ser Leu Phe Gln Ser Thr Glu Ser Glu Ser 
    50                  55                  60                  


Gln Ala Pro Thr Ser Ile Thr Leu Ile Ser Thr Asp Lys Ala Glu Gln 
65                  70                  75                  80  


Val Asn Thr Glu Glu Asn Lys Asn Asp Ser Val Leu Arg Cys Ser Phe 
                85                  90                  95      


Ala Asp Leu Ser Asp Phe Cys Leu Ala Leu Gly Lys Asp Lys Asp Tyr 
            100                 105                 110         


Thr Asp Glu Ser Glu His Ala Thr Tyr Asp Arg Ser Arg Leu Ile Asn 
        115                 120                 125             


Asp Phe Val Ile Lys Asp Lys Ser Glu Phe Lys Thr Lys Leu Ser Lys 
    130                 135                 140                 


Asn Asp Met Asn Tyr Ile Ala Ser Ser Gly Pro Leu Phe Lys Asp Gly 
145                 150                 155                 160 


Lys Lys Arg Ile Asp Tyr Ile Leu Val Tyr Arg Lys Thr Asn Ile Gln 
                165                 170                 175     


Tyr Asp Lys Arg Asn Thr Phe Glu Lys Asn Leu Arg Ala Glu Gly Leu 
            180                 185                 190         


Met Leu Glu Lys Glu Pro Ala Ile Ala Ser Pro Asp Ile Met Phe Ile 
        195                 200                 205             


Lys Ile His Ile Pro Trp Asp Thr Leu Cys Lys Tyr Ala Glu Arg Leu 
    210                 215                 220                 


Asn Ile Arg Met Pro Phe Arg Lys Lys Cys Tyr Tyr Thr Asp Gly Arg 
225                 230                 235                 240 


Ser Lys Ser Met Gly Arg Met Gln Thr Tyr Phe Arg Arg Ile Lys Asn 
                245                 250                 255     


Trp Met Ala Gln Asn Pro Met Val Leu Asp Lys Ser Ala Phe Pro Asp 
            260                 265                 270         


Leu Glu Glu Ser Asp Cys Tyr Thr Gly Pro Phe Ser Arg Ala Arg Ile 
        275                 280                 285             


His His Phe Ile Ile Asn Asn Lys Asp Thr Phe Phe Ser Asn Ala Thr 
    290                 295                 300                 


Arg Ser Arg Ile Val Tyr His Met Leu Glu Arg Thr Lys Tyr Glu Asn 
305                 310                 315                 320 


Gly Ile Ser Lys Val Gly Ile Arg Lys Leu Ile Asn Asn Gly Ser Tyr 
                325                 330                 335     


Ile Ala Ala Phe Pro Pro His Glu Gly Ala Tyr Lys Ser Ser Gln Pro 
            340                 345                 350         


Ile Lys Thr His Gly Pro Gln Asn Asn Arg His Leu Leu Tyr Glu Arg 
        355                 360                 365             


Trp Ala Arg Trp Gly Met Trp Tyr Lys His Gln Pro Leu Asp Leu Ile 
    370                 375                 380                 


Arg Leu Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
385                 390                 395                 400 


Trp Tyr Thr Gly Met Leu Ile Pro Ala Ala Ile Val Gly Leu Cys Val 
                405                 410                 415     


Phe Phe Tyr Gly Leu Phe Thr Met Asn Asn Ser Gln Val Ser Gln Glu 
            420                 425                 430         


Ile Cys Lys Ala Thr Glu Val Phe Met Cys Pro Leu Cys Asp Lys Asn 
        435                 440                 445             


Cys Ser Leu Gln Arg Leu Asn Asp Ser Cys Ile Tyr Ala Lys Val Thr 
    450                 455                 460                 


Tyr Leu Phe Asp Asn Gly Gly Thr Val Phe Phe Ala Ile Phe Met Ala 
465                 470                 475                 480 


Ile Trp Ala Thr Val Phe Leu Glu Phe Trp Lys Arg Arg Arg Ser Ile 
                485                 490                 495     


Leu Thr Tyr Thr Trp Asp Leu Ile Glu Trp Glu Glu Glu Glu Glu Thr 
            500                 505                 510         


Leu Arg Pro Gln Phe Glu Ala Lys Tyr Tyr Lys Met Glu Ile Val Asn 
        515                 520                 525             


Pro Ile Thr Gly Lys Pro Glu Pro His Gln Pro Ser Ser Asp Lys Val 
    530                 535                 540                 


Thr Arg Leu Leu Val Ser Val Ser Gly Ile Phe Phe Met Ile Ser Leu 
545                 550                 555                 560 


Val Ile Thr Ala Val Phe Gly Val Val Val Tyr Arg Leu Val Val Met 
                565                 570                 575     


Glu Gln Phe Ala Ser Phe Lys Trp Asn Phe Ile Lys Gln Tyr Trp Gln 
            580                 585                 590         


Phe Ala Thr Ser Ala Ala Ala Val Cys Ile Asn Phe Ile Ile Ile Met 
        595                 600                 605             


Leu Leu Asn Leu Ala Tyr Glu Lys Ile Ala Tyr Leu Leu Thr Asn Leu 
    610                 615                 620                 


Glu Tyr Pro Arg Thr Glu Ser Glu Trp Glu Asn Ser Phe Ala Leu Lys 
625                 630                 635                 640 


Met Phe Leu Phe Gln Phe Val Asn Leu Asn Ser Ser Ile Phe Tyr Ile 
                645                 650                 655     


Ala Phe Phe Leu Gly Arg Phe Val Gly His Pro Gly Lys Tyr Asn Lys 
            660                 665                 670         


Leu Phe Asp Arg Trp Arg Leu Glu Glu Cys His Pro Ser Gly Cys Leu 
        675                 680                 685             


Ile Asp Leu Cys Leu Gln Met Gly Val Ile Met Phe Leu Lys Gln Ile 
    690                 695                 700                 


Trp Asn Asn Phe Met Glu Leu Gly Tyr Pro Leu Ile Gln Asn Trp Trp 
705                 710                 715                 720 


Ser Arg His Lys Ile Lys Arg Gly Ile His Asp Ala Ser Ile Pro Gln 
                725                 730                 735     


Trp Glu Asn Asp Trp Asn Leu Gln Pro Met Asn Leu His Gly Leu Met 
            740                 745                 750         


Asp Glu Tyr Leu Glu Met Val Leu Gln Phe Gly Phe Thr Thr Ile Phe 
        755                 760                 765             


Val Ala Ala Phe Pro Leu Ala Pro Leu Leu Ala Leu Leu Asn Asn Ile 
    770                 775                 780                 


Ile Glu Ile Arg Leu Asp Ala Tyr Lys Phe Val Thr Gln Trp Arg Arg 
785                 790                 795                 800 


Pro Leu Pro Ala Arg Ala Thr Asp Ile Gly Ile Trp Leu Gly Ile Leu 
                805                 810                 815     


Glu Gly Ile Gly Ile Leu Ala Val Ile Thr Asn Ala Phe Val Ile Ala 
            820                 825                 830         


Ile Thr Ser Asp Tyr Ile Pro Arg Phe Val Tyr Glu Tyr Lys Tyr Gly 
        835                 840                 845             


Pro Cys Ala Asn His Val Glu Pro Ser Glu Asn Cys Leu Lys Gly Tyr 
    850                 855                 860                 


Val Asn Asn Ser Leu Ser Phe Phe Asp Leu Ser Glu Leu Gly Met Gly 
865                 870                 875                 880 


Lys Ser Gly Tyr Cys Arg Tyr Arg Asp Tyr Arg Gly Pro Pro Trp Ser 
                885                 890                 895     


Ser Lys Pro Tyr Glu Phe Thr Leu Gln Tyr Trp His Ile Leu Ala Ala 
            900                 905                 910         


Arg Leu Ala Phe Ile Ile Val Phe Glu His Leu Val Phe Gly Ile Lys 
        915                 920                 925             


Ser Phe Ile Ala Tyr Leu Ile Pro Asp Val Pro Lys Gly Leu His Asp 
    930                 935                 940                 


Arg Ile Arg Arg Glu Lys Tyr Leu Val Gln Glu Met Met Tyr Glu Ala 
945                 950                 955                 960 


Glu Leu Glu His Leu Gln Gln Gln Arg Arg Lys Ser Gly Gln Pro Val 
                965                 970                 975     


His His Glu Trp Pro 
            980     


<210>  564
<211>  955
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO4__Homo_sapiens__NP_001273545

<400>  564

Met Glu Ala Ser Ser Ser Gly Ile Thr Asn Gly Lys Thr Lys Val Phe 
1               5                   10                  15      


His Pro Glu Gly Gly Val Asp Leu Gln Gly Tyr Gln Leu Asp Met Gln 
            20                  25                  30          


Ile Leu Pro Asp Gly Pro Lys Ser Asp Val Asp Phe Ser Glu Ile Leu 
        35                  40                  45              


Asn Ala Ile Gln Glu Met Ala Lys Asp Val Asn Ile Leu Phe Asp Glu 
    50                  55                  60                  


Leu Glu Ala Val Ser Ser Pro Cys Lys Asp Asp Asp Ser Leu Leu His 
65                  70                  75                  80  


Pro Gly Asn Leu Thr Ser Thr Ser Asp Asp Ala Ser Arg Leu Glu Ala 
                85                  90                  95      


Gly Gly Glu Thr Val Pro Glu Arg Asn Lys Ser Asn Gly Leu Tyr Phe 
            100                 105                 110         


Arg Asp Gly Lys Cys Arg Ile Asp Tyr Ile Leu Val Tyr Arg Lys Ser 
        115                 120                 125             


Asn Pro Gln Thr Glu Lys Arg Glu Val Phe Glu Arg Asn Ile Arg Ala 
    130                 135                 140                 


Glu Gly Leu Gln Met Glu Lys Glu Ser Ser Leu Ile Asn Ser Asp Ile 
145                 150                 155                 160 


Ile Phe Val Lys Leu His Ala Pro Trp Glu Val Leu Gly Arg Tyr Ala 
                165                 170                 175     


Glu Gln Met Asn Val Arg Met Pro Phe Arg Arg Lys Ile Tyr Tyr Leu 
            180                 185                 190         


Pro Arg Arg Tyr Lys Phe Met Ser Arg Ile Asp Lys Gln Ile Ser Arg 
        195                 200                 205             


Phe Arg Arg Trp Leu Pro Lys Lys Pro Met Arg Leu Asp Lys Glu Thr 
    210                 215                 220                 


Leu Pro Asp Leu Glu Glu Asn Asp Cys Tyr Thr Ala Pro Phe Ser Gln 
225                 230                 235                 240 


Gln Arg Ile His His Phe Ile Ile His Asn Lys Glu Thr Phe Phe Asn 
                245                 250                 255     


Asn Ala Thr Arg Ser Arg Ile Val His His Ile Leu Gln Arg Ile Lys 
            260                 265                 270         


Tyr Glu Glu Gly Lys Asn Lys Ile Gly Leu Asn Arg Leu Leu Thr Asn 
        275                 280                 285             


Gly Ser Tyr Glu Ala Ala Phe Pro Leu His Glu Gly Ser Tyr Arg Ser 
    290                 295                 300                 


Lys Asn Ser Ile Arg Thr His Gly Ala Glu Asn His Arg His Leu Leu 
305                 310                 315                 320 


Tyr Glu Cys Trp Ala Ser Trp Gly Val Trp Tyr Lys Tyr Gln Pro Leu 
                325                 330                 335     


Asp Leu Val Arg Arg Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala 
            340                 345                 350         


Trp Leu Gly Trp Tyr Thr Gly Met Leu Phe Pro Ala Ala Phe Ile Gly 
        355                 360                 365             


Leu Phe Val Phe Leu Tyr Gly Val Thr Thr Leu Asp His Ser Gln Val 
    370                 375                 380                 


Ser Lys Glu Val Cys Gln Ala Thr Asp Ile Ile Met Cys Pro Val Cys 
385                 390                 395                 400 


Asp Lys Tyr Cys Pro Phe Met Arg Leu Ser Asp Ser Cys Val Tyr Ala 
                405                 410                 415     


Lys Val Thr His Leu Phe Asp Asn Gly Ala Thr Val Phe Phe Ala Val 
            420                 425                 430         


Phe Met Ala Val Trp Ala Thr Val Phe Leu Glu Phe Trp Lys Arg Arg 
        435                 440                 445             


Arg Ala Val Ile Ala Tyr Asp Trp Asp Leu Ile Asp Trp Glu Glu Glu 
    450                 455                 460                 


Glu Glu Glu Ile Arg Pro Gln Phe Glu Ala Lys Tyr Ser Lys Lys Glu 
465                 470                 475                 480 


Arg Met Asn Pro Ile Ser Gly Lys Pro Glu Pro Tyr Gln Ala Phe Thr 
                485                 490                 495     


Asp Lys Cys Ser Arg Leu Ile Val Ser Ala Ser Gly Ile Phe Phe Met 
            500                 505                 510         


Ile Cys Val Val Ile Ala Ala Val Phe Gly Ile Val Ile Tyr Arg Val 
        515                 520                 525             


Val Thr Val Ser Thr Phe Ala Ala Phe Lys Trp Ala Leu Ile Arg Asn 
    530                 535                 540                 


Asn Ser Gln Val Ala Thr Thr Gly Thr Ala Val Cys Ile Asn Phe Cys 
545                 550                 555                 560 


Ile Ile Met Leu Leu Asn Val Leu Tyr Glu Lys Val Ala Leu Leu Leu 
                565                 570                 575     


Thr Asn Leu Glu Gln Pro Arg Thr Glu Ser Glu Trp Glu Asn Ser Phe 
            580                 585                 590         


Thr Leu Lys Met Phe Leu Phe Gln Phe Val Asn Leu Asn Ser Ser Thr 
        595                 600                 605             


Phe Tyr Ile Ala Phe Phe Leu Gly Arg Phe Thr Gly His Pro Gly Ala 
    610                 615                 620                 


Tyr Leu Arg Leu Ile Asn Arg Trp Arg Leu Glu Glu Cys His Pro Ser 
625                 630                 635                 640 


Gly Cys Leu Ile Asp Leu Cys Met Gln Met Gly Ile Ile Met Val Leu 
                645                 650                 655     


Lys Gln Thr Trp Asn Asn Phe Met Glu Leu Gly Tyr Pro Leu Ile Gln 
            660                 665                 670         


Asn Trp Trp Thr Arg Arg Lys Val Arg Gln Glu His Gly Pro Glu Arg 
        675                 680                 685             


Lys Ile Ser Phe Pro Gln Trp Glu Lys Asp Tyr Asn Leu Gln Pro Met 
    690                 695                 700                 


Asn Ala Tyr Gly Leu Phe Asp Glu Tyr Leu Glu Met Ile Leu Gln Phe 
705                 710                 715                 720 


Gly Phe Thr Thr Ile Phe Val Ala Ala Phe Pro Leu Ala Pro Leu Leu 
                725                 730                 735     


Ala Leu Leu Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Tyr Lys Phe 
            740                 745                 750         


Val Thr Gln Trp Arg Arg Pro Leu Ala Ser Arg Ala Lys Asp Ile Gly 
        755                 760                 765             


Ile Trp Tyr Gly Ile Leu Glu Gly Ile Gly Ile Leu Ser Val Ile Thr 
    770                 775                 780                 


Asn Ala Phe Val Ile Ala Ile Thr Ser Asp Phe Ile Pro Arg Leu Val 
785                 790                 795                 800 


Tyr Ala Tyr Lys Tyr Gly Pro Cys Ala Gly Gln Gly Glu Ala Gly Gln 
                805                 810                 815     


Lys Cys Met Val Gly Tyr Val Asn Ala Ser Leu Ser Val Phe Arg Ile 
            820                 825                 830         


Ser Asp Phe Glu Asn Arg Ser Glu Pro Glu Ser Asp Gly Ser Glu Phe 
        835                 840                 845             


Ser Gly Thr Pro Leu Lys Tyr Cys Arg Tyr Arg Asp Tyr Arg Asp Pro 
    850                 855                 860                 


Pro His Ser Leu Val Pro Tyr Gly Tyr Thr Leu Gln Phe Trp His Val 
865                 870                 875                 880 


Leu Ala Ala Arg Leu Ala Phe Ile Ile Val Phe Glu His Leu Val Phe 
                885                 890                 895     


Cys Ile Lys His Leu Ile Ser Tyr Leu Ile Pro Asp Leu Pro Lys Asp 
            900                 905                 910         


Leu Arg Asp Arg Met Arg Arg Glu Lys Tyr Leu Ile Gln Glu Met Met 
        915                 920                 925             


Tyr Glu Ala Glu Leu Glu Arg Leu Gln Lys Glu Arg Lys Glu Arg Lys 
    930                 935                 940                 


Lys Asn Gly Lys Ala His His Asn Glu Trp Pro 
945                 950                 955 


<210>  565
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO5__Homo_sapiens__NP_998764

<400>  565

Met Gly Asp Pro Asp Leu Leu Glu Val Leu Ala Glu Glu Gly Glu Lys 
1               5                   10                  15      


Val Asn Lys His Ile Asp Tyr Ser Phe Gln Met Ser Glu Gln Ser Leu 
            20                  25                  30          


Ser Ser Arg Glu Thr Ser Phe Leu Ile Asn Glu Glu Thr Met Pro Ala 
        35                  40                  45              


Lys Arg Phe Asn Leu Phe Leu Arg Arg Arg Leu Met Phe Gln Lys Asn 
    50                  55                  60                  


Gln Gln Ser Lys Asp Ser Ile Phe Phe Arg Asp Gly Ile Arg Gln Ile 
65                  70                  75                  80  


Asp Phe Val Leu Ser Tyr Val Asp Asp Val Lys Lys Asp Ala Glu Leu 
                85                  90                  95      


Lys Ala Glu Arg Arg Lys Glu Phe Glu Thr Asn Leu Arg Lys Thr Gly 
            100                 105                 110         


Leu Glu Leu Glu Ile Glu Asp Lys Arg Asp Ser Glu Asp Gly Arg Thr 
        115                 120                 125             


Tyr Phe Val Lys Ile His Ala Pro Trp Glu Val Leu Val Thr Tyr Ala 
    130                 135                 140                 


Glu Val Leu Gly Ile Lys Met Pro Ile Lys Glu Ser Asp Ile Pro Arg 
145                 150                 155                 160 


Pro Lys His Thr Pro Ile Ser Tyr Val Leu Gly Pro Val Arg Leu Pro 
                165                 170                 175     


Leu Ser Val Lys Tyr Pro His Pro Glu Tyr Phe Thr Ala Gln Phe Ser 
            180                 185                 190         


Arg His Arg Gln Glu Leu Phe Leu Ile Glu Asp Gln Ala Thr Phe Phe 
        195                 200                 205             


Pro Ser Ser Ser Arg Asn Arg Ile Val Tyr Tyr Ile Leu Ser Arg Cys 
    210                 215                 220                 


Pro Phe Gly Ile Glu Asp Gly Lys Lys Arg Phe Gly Ile Glu Arg Leu 
225                 230                 235                 240 


Leu Asn Ser Asn Thr Tyr Ser Ser Ala Tyr Pro Leu His Asp Gly Gln 
                245                 250                 255     


Tyr Trp Lys Pro Ser Glu Pro Pro Asn Pro Thr Asn Glu Arg Tyr Thr 
            260                 265                 270         


Leu His Gln Asn Trp Ala Arg Phe Ser Tyr Phe Tyr Lys Glu Gln Pro 
        275                 280                 285             


Leu Asp Leu Ile Lys Asn Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe 
    290                 295                 300                 


Val Phe Leu Gly Phe Tyr Thr Glu Met Leu Phe Phe Ala Ala Val Val 
305                 310                 315                 320 


Gly Leu Ala Cys Phe Ile Tyr Gly Leu Leu Ser Met Glu His Asn Thr 
                325                 330                 335     


Ser Ser Thr Glu Ile Cys Asp Pro Glu Ile Gly Gly Gln Met Ile Met 
            340                 345                 350         


Cys Pro Leu Cys Asp Gln Val Cys Asp Tyr Trp Arg Leu Asn Ser Thr 
        355                 360                 365             


Cys Leu Ala Ser Lys Phe Ser His Leu Phe Asp Asn Glu Ser Thr Val 
    370                 375                 380                 


Phe Phe Ala Ile Phe Met Gly Ile Trp Val Thr Leu Phe Leu Glu Phe 
385                 390                 395                 400 


Trp Lys Gln Arg Gln Ala Arg Leu Glu Tyr Glu Trp Asp Leu Val Asp 
                405                 410                 415     


Phe Glu Glu Glu Gln Gln Gln Leu Gln Leu Arg Pro Glu Phe Glu Ala 
            420                 425                 430         


Met Cys Lys His Arg Lys Leu Asn Ala Val Thr Lys Glu Met Glu Pro 
        435                 440                 445             


Tyr Met Pro Leu Tyr Thr Arg Ile Pro Trp Tyr Phe Leu Ser Gly Ala 
    450                 455                 460                 


Thr Val Thr Leu Trp Met Ser Leu Val Val Thr Ser Met Val Ala Val 
465                 470                 475                 480 


Ile Val Tyr Arg Leu Ser Val Phe Ala Thr Phe Ala Ser Phe Met Glu 
                485                 490                 495     


Ser Asp Ala Ser Leu Lys Gln Val Lys Ser Phe Leu Thr Pro Gln Ile 
            500                 505                 510         


Thr Thr Ser Leu Thr Gly Ser Cys Leu Asn Phe Ile Val Ile Leu Ile 
        515                 520                 525             


Leu Asn Phe Phe Tyr Glu Lys Ile Ser Ala Trp Ile Thr Lys Met Glu 
    530                 535                 540                 


Ile Pro Arg Thr Tyr Gln Glu Tyr Glu Ser Ser Leu Thr Leu Lys Met 
545                 550                 555                 560 


Phe Leu Phe Gln Phe Val Asn Phe Tyr Ser Ser Cys Phe Tyr Val Ala 
                565                 570                 575     


Phe Phe Lys Gly Lys Phe Val Gly Tyr Pro Gly Lys Tyr Thr Tyr Leu 
            580                 585                 590         


Phe Asn Glu Trp Arg Ser Glu Glu Cys Asp Pro Gly Gly Cys Leu Ile 
        595                 600                 605             


Glu Leu Thr Thr Gln Leu Thr Ile Ile Met Thr Gly Lys Gln Ile Phe 
    610                 615                 620                 


Gly Asn Ile Lys Glu Ala Ile Tyr Pro Leu Ala Leu Asn Trp Trp Arg 
625                 630                 635                 640 


Arg Arg Lys Ala Arg Thr Asn Ser Glu Lys Leu Tyr Ser Arg Trp Glu 
                645                 650                 655     


Gln Asp His Asp Leu Glu Ser Phe Gly Pro Leu Gly Leu Phe Tyr Glu 
            660                 665                 670         


Tyr Leu Glu Thr Val Thr Gln Phe Gly Phe Val Thr Leu Phe Val Ala 
        675                 680                 685             


Ser Phe Pro Leu Ala Pro Leu Leu Ala Leu Ile Asn Asn Ile Val Glu 
    690                 695                 700                 


Ile Arg Val Asp Ala Trp Lys Leu Thr Thr Gln Tyr Arg Arg Thr Val 
705                 710                 715                 720 


Ala Ser Lys Ala His Ser Ile Gly Val Trp Gln Asp Ile Leu Tyr Gly 
                725                 730                 735     


Met Ala Val Leu Ser Val Ala Thr Asn Ala Phe Ile Val Ala Phe Thr 
            740                 745                 750         


Ser Asp Ile Ile Pro Arg Leu Val Tyr Tyr Tyr Ala Tyr Ser Thr Asn 
        755                 760                 765             


Ala Thr Gln Pro Met Thr Gly Tyr Val Asn Asn Ser Leu Ser Val Phe 
    770                 775                 780                 


Leu Ile Ala Asp Phe Pro Asn His Thr Ala Pro Ser Glu Lys Arg Asp 
785                 790                 795                 800 


Phe Ile Thr Cys Arg Tyr Arg Asp Tyr Arg Tyr Pro Pro Asp Asp Glu 
                805                 810                 815     


Asn Lys Tyr Phe His Asn Met Gln Phe Trp His Val Leu Ala Ala Lys 
            820                 825                 830         


Met Thr Phe Ile Ile Val Met Glu His Val Val Phe Leu Val Lys Phe 
        835                 840                 845             


Leu Leu Ala Trp Met Ile Pro Asp Val Pro Lys Asp Val Val Glu Arg 
    850                 855                 860                 


Ile Lys Arg Glu Lys Leu Met Thr Ile Lys Ile Leu His Asp Phe Glu 
865                 870                 875                 880 


Leu Asn Lys Leu Lys Glu Asn Leu Gly Ile Asn Ser Asn Glu Phe Ala 
                885                 890                 895     


Lys His Val Met Ile Glu Glu Asn Lys Ala Gln Leu Ala Lys Ser Thr 
            900                 905                 910         


Leu 
    


<210>  566
<211>  910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO6__Homo_sapiens__NP_001020527

<400>  566

Met Lys Lys Met Ser Arg Asn Val Leu Leu Gln Met Glu Glu Glu Glu 
1               5                   10                  15      


Asp Asp Asp Asp Gly Asp Ile Val Leu Glu Asn Leu Gly Gln Thr Ile 
            20                  25                  30          


Val Pro Asp Leu Gly Ser Leu Glu Ser Gln His Asp Phe Arg Thr Pro 
        35                  40                  45              


Glu Phe Glu Glu Phe Asn Gly Lys Pro Asp Ser Leu Phe Phe Asn Asp 
    50                  55                  60                  


Gly Gln Arg Arg Ile Asp Phe Val Leu Val Tyr Glu Asp Glu Ser Arg 
65                  70                  75                  80  


Lys Glu Thr Asn Lys Lys Gly Thr Asn Glu Lys Gln Arg Arg Lys Arg 
                85                  90                  95      


Gln Ala Tyr Glu Ser Asn Leu Ile Cys His Gly Leu Gln Leu Glu Ala 
            100                 105                 110         


Thr Arg Ser Val Leu Asp Asp Lys Leu Val Phe Val Lys Val His Ala 
        115                 120                 125             


Pro Trp Glu Val Leu Cys Thr Tyr Ala Glu Ile Met His Ile Lys Leu 
    130                 135                 140                 


Pro Leu Lys Pro Asn Asp Leu Lys Asn Arg Ser Ser Ala Phe Gly Thr 
145                 150                 155                 160 


Leu Asn Trp Phe Thr Lys Val Leu Ser Val Asp Glu Ser Ile Ile Lys 
                165                 170                 175     


Pro Glu Gln Glu Phe Phe Thr Ala Pro Phe Glu Lys Asn Arg Met Asn 
            180                 185                 190         


Asp Phe Tyr Ile Val Asp Arg Asp Ala Phe Phe Asn Pro Ala Thr Arg 
        195                 200                 205             


Ser Arg Ile Val Tyr Phe Ile Leu Ser Arg Val Lys Tyr Gln Val Ile 
    210                 215                 220                 


Asn Asn Val Ser Lys Phe Gly Ile Asn Arg Leu Val Asn Ser Gly Ile 
225                 230                 235                 240 


Tyr Lys Ala Ala Phe Pro Leu His Asp Cys Lys Phe Arg Arg Gln Ser 
                245                 250                 255     


Glu Asp Pro Ser Cys Pro Asn Glu Arg Tyr Leu Leu Tyr Arg Glu Trp 
            260                 265                 270         


Ala His Pro Arg Ser Ile Tyr Lys Lys Gln Pro Leu Asp Leu Ile Arg 
        275                 280                 285             


Lys Tyr Tyr Gly Glu Lys Ile Gly Ile Tyr Phe Ala Trp Leu Gly Tyr 
    290                 295                 300                 


Tyr Thr Gln Met Leu Leu Leu Ala Ala Val Val Gly Val Ala Cys Phe 
305                 310                 315                 320 


Leu Tyr Gly Tyr Leu Asn Gln Asp Asn Cys Thr Trp Ser Lys Glu Val 
                325                 330                 335     


Cys His Pro Asp Ile Gly Gly Lys Ile Ile Met Cys Pro Gln Cys Asp 
            340                 345                 350         


Arg Leu Cys Pro Phe Trp Lys Leu Asn Ile Thr Cys Glu Ser Ser Lys 
        355                 360                 365             


Lys Leu Cys Ile Phe Asp Ser Phe Gly Thr Leu Val Phe Ala Val Phe 
    370                 375                 380                 


Met Gly Val Trp Val Thr Leu Phe Leu Glu Phe Trp Lys Arg Arg Gln 
385                 390                 395                 400 


Ala Glu Leu Glu Tyr Glu Trp Asp Thr Val Glu Leu Gln Gln Glu Glu 
                405                 410                 415     


Gln Ala Arg Pro Glu Tyr Glu Ala Arg Cys Thr His Val Val Ile Asn 
            420                 425                 430         


Glu Ile Thr Gln Glu Glu Glu Arg Ile Pro Phe Thr Ala Trp Gly Lys 
        435                 440                 445             


Cys Ile Arg Ile Thr Leu Cys Ala Ser Ala Val Phe Phe Trp Ile Leu 
    450                 455                 460                 


Leu Ile Ile Ala Ser Val Ile Gly Ile Ile Val Tyr Arg Leu Ser Val 
465                 470                 475                 480 


Phe Ile Val Phe Ser Ala Lys Leu Pro Lys Asn Ile Asn Gly Thr Asp 
                485                 490                 495     


Pro Ile Gln Lys Tyr Leu Thr Pro Gln Thr Ala Thr Ser Ile Thr Ala 
            500                 505                 510         


Ser Ile Ile Ser Phe Ile Ile Ile Met Ile Leu Asn Thr Ile Tyr Glu 
        515                 520                 525             


Lys Val Ala Ile Met Ile Thr Asn Phe Glu Leu Pro Arg Thr Gln Thr 
    530                 535                 540                 


Asp Tyr Glu Asn Ser Leu Thr Met Lys Met Phe Leu Phe Gln Phe Val 
545                 550                 555                 560 


Asn Tyr Tyr Ser Ser Cys Phe Tyr Ile Ala Phe Phe Lys Gly Lys Phe 
                565                 570                 575     


Val Gly Tyr Pro Gly Asp Pro Val Tyr Trp Leu Gly Lys Tyr Arg Asn 
            580                 585                 590         


Glu Glu Cys Asp Pro Gly Gly Cys Leu Leu Glu Leu Thr Thr Gln Leu 
        595                 600                 605             


Thr Ile Ile Met Gly Gly Lys Ala Ile Trp Asn Asn Ile Gln Glu Val 
    610                 615                 620                 


Leu Leu Pro Trp Ile Met Asn Leu Ile Gly Arg Phe His Arg Val Ser 
625                 630                 635                 640 


Gly Ser Glu Lys Ile Thr Pro Arg Trp Glu Gln Asp Tyr His Leu Gln 
                645                 650                 655     


Pro Met Gly Lys Leu Gly Leu Phe Tyr Glu Tyr Leu Glu Met Ile Ile 
            660                 665                 670         


Gln Phe Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro 
        675                 680                 685             


Leu Leu Ala Leu Val Asn Asn Ile Leu Glu Ile Arg Val Asp Ala Trp 
    690                 695                 700                 


Lys Leu Thr Thr Gln Phe Arg Arg Leu Val Pro Glu Lys Ala Gln Asp 
705                 710                 715                 720 


Ile Gly Ala Trp Gln Pro Ile Met Gln Gly Ile Ala Ile Leu Ala Val 
                725                 730                 735     


Val Thr Asn Ala Met Ile Ile Ala Phe Thr Ser Asp Met Ile Pro Arg 
            740                 745                 750         


Leu Val Tyr Tyr Trp Ser Phe Ser Val Pro Pro Tyr Gly Asp His Thr 
        755                 760                 765             


Ser Tyr Thr Met Glu Gly Tyr Ile Asn Asn Thr Leu Ser Ile Phe Lys 
    770                 775                 780                 


Val Ala Asp Phe Lys Asn Lys Ser Lys Gly Asn Pro Tyr Ser Asp Leu 
785                 790                 795                 800 


Gly Asn His Thr Thr Cys Arg Tyr Arg Asp Phe Arg Tyr Pro Pro Gly 
                805                 810                 815     


His Pro Gln Glu Tyr Lys His Asn Ile Tyr Tyr Trp His Val Ile Ala 
            820                 825                 830         


Ala Lys Leu Ala Phe Ile Ile Val Met Glu His Val Ile Tyr Ser Val 
        835                 840                 845             


Lys Phe Phe Ile Ser Tyr Ala Ile Pro Asp Val Ser Lys Arg Thr Lys 
    850                 855                 860                 


Ser Lys Ile Gln Arg Glu Lys Tyr Leu Thr Gln Lys Leu Leu His Glu 
865                 870                 875                 880 


Asn His Leu Lys Asp Met Thr Lys Asn Met Gly Val Ile Ala Glu Arg 
                885                 890                 895     


Met Ile Glu Ala Val Asp Asn Asn Leu Arg Pro Lys Ser Glu 
            900                 905                 910 


<210>  567
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO7__Homo_sapiens__NP_001001666

<400>  567

Met Arg Met Ala Ala Thr Ala Trp Ala Gly Leu Gln Gly Pro Pro Leu 
1               5                   10                  15      


Pro Thr Leu Cys Pro Ala Val Arg Thr Gly Leu Tyr Cys Arg Asp Gln 
            20                  25                  30          


Ala His Ala Glu Arg Trp Ala Met Thr Ser Glu Thr Ser Ser Gly Ser 
        35                  40                  45              


His Cys Ala Arg Ser Arg Met Leu Arg Arg Arg Ala Gln Glu Glu Asp 
    50                  55                  60                  


Ser Thr Val Leu Ile Asp Val Ser Pro Pro Glu Ala Glu Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Gly Ser Thr Ala His Ala Ser Glu Pro Gly Gly Gln Gln Ala 
                85                  90                  95      


Ala Ala Cys Arg Ala Gly Ser Pro Ala Lys Pro Arg Ile Asp Phe Val 
            100                 105                 110         


Leu Val Trp Glu Glu Asp Leu Lys Leu Asp Arg Gln Gln Asp Ser Ala 
        115                 120                 125             


Ala Arg Asp Arg Thr Asp Met His Arg Thr Trp Arg Glu Thr Phe Leu 
    130                 135                 140                 


Asp Asn Leu Arg Ala Ala Gly Leu Cys Val Asp Gln Val Arg Gly Gly 
145                 150                 155                 160 


Cys His Gly Gln Gly Pro Arg Pro Cys Ile His Ser Val Thr His Asp 
                165                 170                 175     


Leu Ala Ala 
            


<210>  568
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANP32A__Homo_sapiens__NP_006296

<400>  568

Met Glu Met Gly Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Val Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Thr Ile Asn Val Gly Leu Thr Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Asp Asn Arg Val Ser Gly Gly Leu 
65                  70                  75                  80  


Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Thr His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Asn Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Asn Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Asp Asp Lys Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Gly Tyr Val Glu Gly Leu Asp Asp Glu Glu Glu Asp Glu Asp Glu 
                165                 170                 175     


Glu Glu Tyr Asp Glu Asp Ala Gln Val Val Glu Asp Glu Glu Asp Glu 
            180                 185                 190         


Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Val Ser Gly Glu Glu Glu 
        195                 200                 205             


Glu Asp Glu Glu Gly Tyr Asn Asp Gly Glu Val Asp Asp Glu Glu Asp 
    210                 215                 220                 


Glu Glu Glu Leu Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys Arg Glu 
225                 230                 235                 240 


Pro Glu Asp Glu Gly Glu Asp Asp Asp 
                245                 


<210>  569
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANP32B__Homo_sapiens__NP_006392

<400>  569

Met Asp Met Lys Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ala Ala Val Arg Glu Leu Val Leu Asp Asn Cys Lys Ser Asn Asp Gly 
            20                  25                  30          


Lys Ile Glu Gly Leu Thr Ala Glu Phe Val Asn Leu Glu Phe Leu Ser 
        35                  40                  45              


Leu Ile Asn Val Gly Leu Ile Ser Val Ser Asn Leu Pro Lys Leu Pro 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Glu Asn Arg Ile Phe Gly Gly Leu 
65                  70                  75                  80  


Asp Met Leu Ala Glu Lys Leu Pro Asn Leu Thr His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Leu Lys Asp Ile Ser Thr Leu Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Cys Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Ser Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Glu Asp Gln Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Val Asp Gly Val Asp Glu Glu Glu Glu Asp Glu Glu Gly Glu Asp 
                165                 170                 175     


Glu Glu Asp Glu Asp Asp Glu Asp Gly Glu Glu Glu Glu Phe Asp Glu 
            180                 185                 190         


Glu Asp Asp Glu Asp Glu Asp Val Glu Gly Asp Glu Asp Asp Asp Glu 
        195                 200                 205             


Val Ser Glu Glu Glu Glu Glu Phe Gly Leu Asp Glu Glu Asp Glu Asp 
    210                 215                 220                 


Glu Asp Glu Asp Glu Glu Glu Glu Glu Gly Gly Lys Gly Glu Lys Arg 
225                 230                 235                 240 


Lys Arg Glu Thr Asp Asp Glu Gly Glu Asp Asp 
                245                 250     


<210>  570
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANP32D__Homo_sapiens__NP_036536

<400>  570

Met Glu Met Gly Lys Trp Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Phe Leu Asp Asn Ser Gln Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Gly Leu Thr Asp Glu Phe Glu Glu Leu Glu Leu Leu Asn 
        35                  40                  45              


Thr Ile Asn Ile Gly Leu Thr Ser Ile Ala Asn Leu Pro Lys Leu Asn 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Ser Asn Arg Ala Ser Val Gly Leu 
65                  70                  75                  80  


Glu Val Leu Ala Glu Lys Cys Pro Asn Leu Ile His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Ile Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Asn Leu Glu Ser Leu Asp Leu Phe Thr Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asn Tyr 
    130     


<210>  571
<211>  967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANPEP__Homo_sapiens__NP_001141

<400>  571

Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          


Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              


Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  


Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Arg Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      


Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         


Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             


Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 


Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 


Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     


Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         


Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             


Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 


Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 


Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     


Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         


Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             


Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 


Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 


Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     


Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         


Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             


Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 


Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 


Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     


Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         


Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             


Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 


Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 


Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     


Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         


Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             


Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 


Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 


Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     


Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         


Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 
        595                 600                 605             


Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 


Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 


Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     


Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         


Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             


Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 


Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 


Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     


Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         


Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             


Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 


Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 


Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     


Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         


Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             


Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 


Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 


Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     


Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         


Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             


Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 


Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 


Trp Phe Thr Glu Asn Ser Lys 
                965         


<210>  572
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTXR1__Homo_sapiens__NP_060623

<400>  572

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Leu His 
305                 310                 315                 320 


Lys Ile Ala Ser Gly Pro Thr Thr Ala Ala Cys Met Glu 
                325                 330             


<210>  573
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANTXR2__Homo_sapiens__NP_001139266

<400>  573

Met Val Ala Glu Arg Ser Pro Ala Arg Ser Pro Gly Ser Trp Leu Phe 
1               5                   10                  15      


Pro Gly Leu Trp Leu Leu Val Leu Ser Gly Pro Gly Gly Leu Leu Arg 
            20                  25                  30          


Ala Gln Glu Gln Pro Ser Cys Arg Arg Ala Phe Asp Leu Tyr Phe Val 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Ala Asn Asn Trp Ile Glu Ile Tyr Asn 
    50                  55                  60                  


Phe Val Gln Gln Leu Ala Glu Arg Phe Val Ser Pro Glu Met Arg Leu 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Ser Gln Ala Thr Ile Ile Leu Pro Leu Thr 
                85                  90                  95      


Gly Asp Arg Gly Lys Ile Ser Lys Gly Leu Glu Asp Leu Lys Arg Val 
            100                 105                 110         


Ser Pro Val Gly Glu Thr Tyr Ile His Glu Gly Leu Lys Leu Ala Asn 
        115                 120                 125             


Glu Gln Ile Gln Lys Ala Gly Gly Leu Lys Thr Ser Ser Ile Ile Ile 
    130                 135                 140                 


Ala Leu Thr Asp Gly Lys Leu Asp Gly Leu Val Pro Ser Tyr Ala Glu 
145                 150                 155                 160 


Lys Glu Ala Lys Ile Ser Arg Ser Leu Gly Ala Ser Val Tyr Cys Val 
                165                 170                 175     


Gly Val Leu Asp Phe Glu Gln Ala Gln Leu Glu Arg Ile Ala Asp Ser 
            180                 185                 190         


Lys Glu Gln Val Phe Pro Val Lys Gly Gly Phe Gln Ala Leu Lys Gly 
        195                 200                 205             


Ile Ile Asn Ser Ile Leu Ala Gln Ser Cys Thr Glu Ile Leu Glu Leu 
    210                 215                 220                 


Gln Pro Ser Ser Val Cys Val Gly Glu Glu Phe Gln Ile Val Leu Ser 
225                 230                 235                 240 


Gly Arg Gly Phe Met Leu Gly Ser Arg Asn Gly Ser Val Leu Cys Thr 
                245                 250                 255     


Tyr Thr Val Asn Glu Thr Tyr Thr Thr Ser Val Lys Pro Val Ser Val 
            260                 265                 270         


Gln Leu Asn Ser Met Leu Cys Pro Ala Pro Ile Leu Asn Lys Ala Gly 
        275                 280                 285             


Glu Thr Leu Asp Val Ser Val Ser Phe Asn Gly Gly Lys Ser Val Ile 
    290                 295                 300                 


Ser Gly Ser Leu Ile Val Thr Ala Thr Glu Cys Ser Asn Gly Ile Ala 
305                 310                 315                 320 


Ala Ile Ile Val Ile Leu Val Leu Leu Leu Leu Leu Gly Ile Gly Leu 
                325                 330                 335     


Met Trp Trp Phe Trp Pro Leu Cys Cys Lys Val Val Ile Lys Asp Pro 
            340                 345                 350         


Pro Pro Pro Pro Ala Pro Ala Pro Lys Glu Glu Glu Glu Glu Pro Leu 
        355                 360                 365             


Pro Thr Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly Gly Arg 
    370                 375                 380                 


Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Asp Lys Gly 
385                 390                 395                 400 


Ser Thr Glu Glu Gly Ala Arg Leu Glu Lys Ala Lys Asn Ala Val Val 
                405                 410                 415     


Lys Ile Pro Glu Glu Thr Glu Glu Pro Ile Arg Pro Arg Pro Pro Arg 
            420                 425                 430         


Pro Lys Pro Thr His Gln Pro Pro Gln Thr Lys Trp Tyr Thr Pro Ile 
        435                 440                 445             


Lys Gly Arg Leu Asp Ala Leu Trp Ala Leu Leu Arg Arg Gln Tyr Asp 
    450                 455                 460                 


Arg Val Ser Leu Met Arg Pro Gln Glu Gly Asp Glu Val Cys Ile Trp 
465                 470                 475                 480 


Glu Cys Ile Glu Lys Glu Leu Thr Ala 
                485                 


<210>  574
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA10__Homo_sapiens__NP_009124

<400>  574

Met Phe Cys Gly Asp Tyr Val Gln Gly Thr Ile Phe Pro Ala Pro Asn 
1               5                   10                  15      


Phe Asn Pro Ile Met Asp Ala Gln Met Leu Gly Gly Ala Leu Gln Gly 
            20                  25                  30          


Phe Asp Cys Asp Lys Asp Met Leu Ile Asn Ile Leu Thr Gln Arg Cys 
        35                  40                  45              


Asn Ala Gln Arg Met Met Ile Ala Glu Ala Tyr Gln Ser Met Tyr Gly 
    50                  55                  60                  


Arg Asp Leu Ile Gly Asp Met Arg Glu Gln Leu Ser Asp His Phe Lys 
65                  70                  75                  80  


Asp Val Met Ala Gly Leu Met Tyr Pro Pro Pro Leu Tyr Asp Ala His 
                85                  90                  95      


Glu Leu Trp His Ala Met Lys Gly Val Gly Thr Asp Glu Asn Cys Leu 
            100                 105                 110         


Ile Glu Ile Leu Ala Ser Arg Thr Asn Gly Glu Ile Phe Gln Met Arg 
        115                 120                 125             


Glu Ala Tyr Cys Leu Gln Tyr Ser Asn Asn Leu Gln Glu Asp Ile Tyr 
    130                 135                 140                 


Ser Glu Thr Ser Gly His Phe Arg Asp Thr Leu Met Asn Leu Val Gln 
145                 150                 155                 160 


Gly Thr Arg Glu Glu Gly Tyr Thr Asp Pro Ala Met Ala Ala Gln Asp 
                165                 170                 175     


Ala Met Val Leu Trp Glu Ala Cys Gln Gln Lys Thr Gly Glu His Lys 
            180                 185                 190         


Thr Met Leu Gln Met Ile Leu Cys Asn Lys Ser Tyr Gln Gln Leu Arg 
        195                 200                 205             


Leu Val Phe Gln Glu Phe Gln Asn Ile Ser Gly Gln Asp Met Val Asp 
    210                 215                 220                 


Ala Ile Asn Glu Cys Tyr Asp Gly Tyr Phe Gln Glu Leu Leu Val Ala 
225                 230                 235                 240 


Ile Val Leu Cys Val Arg Asp Lys Pro Ala Tyr Phe Ala Tyr Arg Leu 
                245                 250                 255     


Tyr Ser Ala Ile His Asp Phe Gly Phe His Asn Lys Thr Val Ile Arg 
            260                 265                 270         


Ile Leu Ile Ala Arg Ser Glu Ile Asp Leu Leu Thr Ile Arg Lys Arg 
        275                 280                 285             


Tyr Lys Glu Arg Tyr Gly Lys Ser Leu Phe His Asp Ile Arg Asn Phe 
    290                 295                 300                 


Ala Ser Gly His Tyr Lys Lys Ala Leu Leu Ala Ile Cys Ala Gly Asp 
305                 310                 315                 320 


Ala Glu Asp Tyr 
                


<210>  575
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA11__Homo_sapiens__NP_001265336

<400>  575

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            500                 505 


<210>  576
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA13__Homo_sapiens__NP_001003954

<400>  576

Met Gly Asn Arg His Ser Gln Ser Tyr Thr Leu Ser Glu Gly Ser Gln 
1               5                   10                  15      


Gln Leu Pro Lys Gly Asp Ser Gln Pro Ser Thr Val Val Gln Pro Leu 
            20                  25                  30          


Ser His Pro Ser Arg Asn Gly Glu Pro Glu Ala Pro Gln Pro Ala Lys 
        35                  40                  45              


Ala Ser Ser Pro Gln Gly Phe Asp Val Asp Arg Asp Ala Lys Lys Leu 
    50                  55                  60                  


Asn Lys Ala Cys Lys Gly Met Gly Thr Asn Glu Ala Ala Ile Ile Glu 
65                  70                  75                  80  


Ile Leu Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln Ile Lys Gln Lys 
                85                  90                  95      


Tyr Lys Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val Leu Lys Ser Glu 
            100                 105                 110         


Leu Ser Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu Leu Asp Arg Pro 
        115                 120                 125             


Ser Glu Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met Lys Gly Leu Gly 
    130                 135                 140                 


Thr Asp Glu Ser Val Leu Ile Glu Val Leu Cys Thr Arg Thr Asn Lys 
145                 150                 155                 160 


Glu Ile Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu Phe Asp Arg Ser 
                165                 170                 175     


Leu Glu Ser Asp Val Lys Gly Asp Thr Ser Gly Asn Leu Lys Lys Ile 
            180                 185                 190         


Leu Val Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly Asp Asp Val Asp 
        195                 200                 205             


Lys Asp Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr Asp Ala Gly Glu 
    210                 215                 220                 


Gly Arg Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu Val Leu Ala Lys 
225                 230                 235                 240 


Arg Ser Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala Tyr Gln Ile Leu 
                245                 250                 255     


Ile Gly Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu Thr Ser Gly Asp 
            260                 265                 270         


Leu Gln Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala Gln Asp Cys Glu 
        275                 280                 285             


Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr 
    290                 295                 300                 


Asp Glu Glu Thr Leu Ile Arg Ile Val Val Thr Arg Ala Glu Val Asp 
305                 310                 315                 320 


Leu Gln Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr Gln Lys Ser Leu 
                325                 330                 335     


Ser Asp Met Val Arg Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Leu 
            340                 345                 350         


Val Ala Leu Leu His 
        355         


<210>  577
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA1__Homo_sapiens__XP_011516910

<400>  577

Met Asn Leu Ile Leu Arg Tyr Thr Phe Ser Lys Met Ala Met Val Ser 
1               5                   10                  15      


Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn Glu Glu Gln Glu Tyr 
            20                  25                  30          


Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro Gly Ser Ala Val Ser 
        35                  40                  45              


Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys 
    50                  55                  60                  


Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu 
65                  70                  75                  80  


Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu 
                85                  90                  95      


Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr 
            100                 105                 110         


Gly His Leu Glu Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln 
        115                 120                 125             


Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp 
    130                 135                 140                 


Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile 
145                 150                 155                 160 


Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala 
                165                 170                 175     


Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu 
            180                 185                 190         


Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe Gly Val Asn Glu Asp 
        195                 200                 205             


Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu Ala Gly Glu Arg Arg 
    210                 215                 220                 


Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile Leu Thr Thr Arg Ser 
225                 230                 235                 240 


Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr Thr Lys Tyr Ser Lys 
                245                 250                 255     


His Asp Met Asn Lys Val Leu Asp Leu Glu Leu Lys Gly Asp Ile Glu 
            260                 265                 270         


Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr Ser Lys Pro Ala Phe 
        275                 280                 285             


Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly Val Gly Thr Arg His 
    290                 295                 300                 


Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser Glu Ile Asp Met Asn 
305                 310                 315                 320 


Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly Ile Ser Leu Cys Gln 
                325                 330                 335     


Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu Lys Ile Leu Val Ala 
            340                 345                 350         


Leu Cys Gly Gly Asn 
        355         


<210>  578
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA2__Homo_sapiens__NP_001002858

<400>  578

Met Gly Arg Gln Leu Ala Gly Cys Gly Asp Ala Gly Lys Lys Ala Ser 
1               5                   10                  15      


Phe Lys Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu 
            20                  25                  30          


Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr 
        35                  40                  45              


Thr Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile 
    50                  55                  60                  


Lys Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn 
65                  70                  75                  80  


Arg Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg 
                85                  90                  95      


Thr Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His 
            100                 105                 110         


Leu Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp 
        115                 120                 125             


Ala Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp 
    130                 135                 140                 


Ser Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu 
145                 150                 155                 160 


Ile Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp 
                165                 170                 175     


Ile Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu 
            180                 185                 190         


Ala Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu 
        195                 200                 205             


Ile Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys 
    210                 215                 220                 


Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val 
225                 230                 235                 240 


Pro His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr 
                245                 250                 255     


Asp Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn 
            260                 265                 270         


Ala Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe 
        275                 280                 285             


Ala Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys 
    290                 295                 300                 


Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys 
305                 310                 315                 320 


Ile Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr 
                325                 330                 335     


Ile Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu 
            340                 345                 350         


Cys Gly Gly Asp Asp 
        355         


<210>  579
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA2R__Homo_sapiens__NP_001014301

<400>  579

Met Glu Gln His Phe Leu Gly Cys Val Lys Arg Ala Trp Asp Ser Ala 
1               5                   10                  15      


Glu Val Ala Pro Glu Pro Gln Pro Pro Pro Ile Val Ser Ser Glu Asp 
            20                  25                  30          


Arg Gly Pro Trp Pro Leu Pro Leu Tyr Pro Val Leu Gly Glu Tyr Ser 
        35                  40                  45              


Leu Asp Ser Cys Asp Leu Gly Leu Leu Ser Ser Pro Cys Trp Arg Leu 
    50                  55                  60                  


Pro Gly Val Tyr Trp Gln Asn Gly Leu Ser Pro Gly Val Gln Ser Thr 
65                  70                  75                  80  


Leu Glu Pro Ser Thr Ala Lys Pro Thr Glu Phe Ser Trp Pro Gly Thr 
                85                  90                  95      


Gln Lys Gln Gln Glu Ala Pro Val Glu Glu Val Gly Gln Ala Glu Glu 
            100                 105                 110         


Pro Asp Arg Leu Arg Leu Gln Gln Leu Pro Trp Ser Ser Pro Leu His 
        115                 120                 125             


Pro Trp Asp Arg Gln Gln Asp Thr Glu Val Cys Asp Ser Gly Cys Leu 
    130                 135                 140                 


Leu Glu Arg Arg His Pro Pro Ala Leu Gln Pro Trp Arg His Leu Pro 
145                 150                 155                 160 


Gly Phe Ser Asp Cys Leu Glu Trp Ile Leu Arg Val Gly Phe Ala Ala 
                165                 170                 175     


Phe Ser Val Leu Trp Ala Cys Cys Ser Arg Ile Cys Gly Ala Lys Gln 
            180                 185                 190         


Pro 
    


<210>  580
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA3__Homo_sapiens__NP_005130

<400>  580

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15      


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30          


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45              


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60                  


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80  


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95      


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110         


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125             


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140                 


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160 


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175     


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190         


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205             


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220                 


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255     


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270         


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285             


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300                 


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320 


Gly Asp Asp 
            


<210>  581
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA4__Homo_sapiens__NP_001307627

<400>  581

Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu 
            20                  25                  30          


Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr 
        35                  40                  45              


Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg 
    50                  55                  60                  


Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln 
65                  70                  75                  80  


Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu 
                85                  90                  95      


Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile 
            100                 105                 110         


Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln 
        115                 120                 125             


Thr Tyr Gln Gln Gln Tyr Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser 
    130                 135                 140                 


Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly 
145                 150                 155                 160 


Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp 
                165                 170                 175     


Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu 
            180                 185                 190         


Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu 
        195                 200                 205             


His Val Phe Asp Glu Tyr Lys Arg Ile Ser Gln Lys Asp Ile Glu Gln 
    210                 215                 220                 


Ser Ile Lys Ser Glu Thr Ser Gly Ser Phe Glu Asp Ala Leu Leu Ala 
225                 230                 235                 240 


Ile Val Lys Cys Met Arg Asn Lys Ser Ala Tyr Phe Ala Glu Lys Leu 
                245                 250                 255     


Tyr Lys Ser Met Lys Gly Leu Gly Thr Asp Asp Asn Thr Leu Ile Arg 
            260                 265                 270         


Val Met Val Ser Arg Ala Glu Ile Asp Met Leu Asp Ile Arg Ala His 
        275                 280                 285             


Phe Lys Arg Leu Tyr Gly Lys Ser Leu Tyr Ser Phe Ile Lys Gly Asp 
    290                 295                 300                 


Thr Ser Gly Asp Tyr Arg Lys Val Leu Leu Val Leu Cys Gly Gly Asp 
305                 310                 315                 320 


Asp 
    


<210>  582
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA5__Homo_sapiens__NP_001145

<400>  582

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  583
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA6__Homo_sapiens__NP_001146

<400>  583

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp 
    


<210>  584
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA7__Homo_sapiens__NP_001147

<400>  584

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160 


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175     


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190         


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205             


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220                 


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240 


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255     


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270         


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285             


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300                 


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320 


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335     


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350         


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365             


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400 


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415     


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430         


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445             


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460                 


Gly Gln 
465     


<210>  585
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA8__Homo_sapiens__NP_001035173

<400>  585

Met Ala Trp Trp Lys Ser Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Gly Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro 
                325         


<210>  586
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANXA8L1__Homo_sapiens__NP_001092315

<400>  586

Met Ala Trp Trp Lys Ala Trp Ile Glu Gln Glu Gly Val Thr Val Lys 
1               5                   10                  15      


Ser Ser Ser His Phe Asn Pro Asp Pro Asp Ala Glu Thr Leu Tyr Lys 
            20                  25                  30          


Ala Met Lys Gly Ile Gly Thr Asn Glu Gln Ala Ile Ile Asp Val Leu 
        35                  40                  45              


Thr Lys Arg Ser Asn Thr Gln Arg Gln Gln Ile Ala Lys Ser Phe Lys 
    50                  55                  60                  


Ala Gln Phe Gly Lys Asp Leu Thr Glu Thr Leu Lys Ser Glu Leu Ser 
65                  70                  75                  80  


Gly Lys Phe Glu Arg Leu Ile Val Ala Leu Met Tyr Pro Pro Tyr Arg 
                85                  90                  95      


Tyr Glu Ala Lys Glu Leu His Asp Ala Met Lys Gly Leu Gly Thr Lys 
            100                 105                 110         


Glu Gly Val Ile Ile Glu Ile Leu Ala Ser Arg Thr Lys Asn Gln Leu 
        115                 120                 125             


Arg Glu Ile Met Lys Ala Tyr Glu Glu Asp Tyr Gly Ser Ser Leu Glu 
    130                 135                 140                 


Glu Asp Ile Gln Ala Asp Thr Ser Gly Tyr Leu Glu Arg Ile Leu Val 
145                 150                 155                 160 


Cys Leu Leu Gln Gly Ser Arg Asp Asp Val Ser Ser Phe Val Asp Pro 
                165                 170                 175     


Ala Leu Ala Leu Gln Asp Ala Gln Asp Leu Tyr Ala Ala Gly Glu Lys 
            180                 185                 190         


Ile Arg Gly Thr Asp Glu Met Lys Phe Ile Thr Ile Leu Cys Thr Arg 
        195                 200                 205             


Ser Ala Thr His Leu Leu Arg Val Phe Glu Glu Tyr Glu Lys Ile Ala 
    210                 215                 220                 


Asn Lys Ser Ile Glu Asp Ser Ile Lys Ser Glu Thr His Gly Ser Leu 
225                 230                 235                 240 


Glu Glu Ala Met Leu Thr Val Val Lys Cys Thr Gln Asn Leu His Ser 
                245                 250                 255     


Tyr Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Arg 
            260                 265                 270         


Asp Gly Thr Leu Ile Arg Asn Ile Val Ser Arg Ser Glu Ile Asp Leu 
        275                 280                 285             


Asn Leu Ile Lys Cys His Phe Lys Lys Met Tyr Gly Lys Thr Leu Ser 
    290                 295                 300                 


Ser Met Ile Met Glu Asp Thr Ser Gly Asp Tyr Lys Asn Ala Leu Leu 
305                 310                 315                 320 


Ser Leu Val Gly Ser Asp Pro 
                325         


<210>  587
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AOAH__Homo_sapiens__NP_001170977

<400>  587

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Gly Cys Val Leu Val Val 
        35                  40                  45              


Ser Val Ile Glu Gln Leu Ala Gln Val His Asn Ser Thr Val Gln Ala 
    50                  55                  60                  


Ser Met Glu Arg Leu Cys Ser Tyr Leu Pro Glu Lys Leu Phe Leu Lys 
65                  70                  75                  80  


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
                85                  90                  95      


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
            100                 105                 110         


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
        115                 120                 125             


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala Arg Gln Ile Val 
    130                 135                 140                 


Lys Lys Ser Pro Ile Leu Lys Tyr Ser Arg Ser Gly Ser Asp Ile Cys 
145                 150                 155                 160 


Ser Leu Pro Val Leu Ala Lys Ile Cys Gln Lys Ile Lys Leu Ala Met 
                165                 170                 175     


Glu Gln Ser Val Pro Phe Lys Asp Val Asp Ser Asp Lys Tyr Ser Val 
            180                 185                 190         


Phe Pro Thr Leu Arg Gly Tyr His Trp Arg Gly Arg Asp Cys Asn Asp 
        195                 200                 205             


Ser Asp Glu Ser Val Tyr Pro Gly Arg Arg Pro Asn Asn Trp Asp Val 
    210                 215                 220                 


His Gln Asp Ser Asn Cys Asn Gly Ile Trp Gly Val Asp Pro Lys Asp 
225                 230                 235                 240 


Gly Val Pro Tyr Glu Lys Lys Phe Cys Glu Gly Ser Gln Pro Arg Gly 
                245                 250                 255     


Ile Ile Leu Leu Gly Asp Ser Ala Gly Ala His Phe His Ile Ser Pro 
            260                 265                 270         


Glu Trp Ile Thr Ala Ser Gln Met Ser Leu Asn Ser Phe Ile Asn Leu 
        275                 280                 285             


Pro Thr Ala Leu Thr Asn Glu Leu Asp Trp Pro Gln Leu Ser Gly Ala 
    290                 295                 300                 


Thr Gly Phe Leu Asp Ser Thr Val Gly Ile Lys Glu Lys Ser Ile Tyr 
305                 310                 315                 320 


Leu Arg Leu Trp Lys Arg Asn His Cys Asn His Arg Asp Tyr Gln Asn 
                325                 330                 335     


Ile Ser Arg Asn Gly Ala Ser Ser Arg Asn Leu Lys Lys Phe Ile Glu 
            340                 345                 350         


Ser Leu Ser Arg Asn Lys Val Leu Asp Tyr Pro Ala Ile Val Ile Tyr 
        355                 360                 365             


Ala Met Ile Gly Asn Asp Val Cys Ser Gly Lys Ser Asp Pro Val Pro 
    370                 375                 380                 


Ala Met Thr Thr Pro Glu Lys Leu Tyr Ser Asn Val Met Gln Thr Leu 
385                 390                 395                 400 


Lys His Leu Asn Ser His Leu Pro Asn Gly Ser His Val Ile Leu Tyr 
                405                 410                 415     


Gly Leu Pro Asp Gly Thr Phe Leu Trp Asp Asn Leu His Asn Arg Tyr 
            420                 425                 430         


His Pro Leu Gly Gln Leu Asn Lys Asp Met Thr Tyr Ala Gln Leu Tyr 
        435                 440                 445             


Ser Phe Leu Asn Cys Leu Gln Val Ser Pro Cys His Gly Trp Met Ser 
    450                 455                 460                 


Ser Asn Lys Thr Leu Arg Thr Leu Thr Ser Glu Arg Ala Glu Gln Leu 
465                 470                 475                 480 


Ser Asn Thr Leu Lys Lys Ile Ala Ala Ser Glu Lys Phe Thr Asn Phe 
                485                 490                 495     


Asn Leu Phe Tyr Met Asp Phe Ala Phe His Glu Ile Ile Gln Glu Trp 
            500                 505                 510         


Gln Lys Arg Gly Gly Gln Pro Trp Gln Leu Ile Glu Pro Val Asp Gly 
        515                 520                 525             


Phe His Pro Asn Glu Arg Lys Ser Ile Leu Leu Lys Gly Ile Leu Met 
    530                 535                 540                 


Thr Ser Gln Thr Leu Asp Asn Gln Glu Trp Thr Gln Leu Thr Ser Trp 
545                 550                 555                 560 


Ile Lys Gly Asn Leu Thr Cys Asp Ser Arg Thr Arg Glu Trp Leu Cys 
                565                 570                 575     


Cys Cys Trp Arg Ile Ile Ser Gly Lys Arg Cys Ser Ser Ser Gly Pro 
            580                 585                 590         


Lys Ser Trp Glu Arg Arg Ile Arg Ser Thr Pro Arg Leu Asn Arg Cys 
        595                 600                 605             


Leu Glu Thr Lys Ala Gly Thr Glu Pro Leu Arg Ser Met His Pro Trp 
    610                 615                 620                 


Gly Ala Gln Gly Gly Arg Gly Leu Gly Lys Leu Ile Pro Gln Thr Leu 
625                 630                 635                 640 


Trp Gly Leu Pro Arg His Arg Pro Lys Gly Leu Phe Phe Ser Ser Ile 
                645                 650                 655     


Phe Ala Lys Cys Leu Ser Leu Asn Glu Glu His Ile Trp Thr Thr Val 
            660                 665                 670         


Gln Cys Cys Val Leu Pro Gly Ser Val Thr Leu Pro Leu Phe Leu Lys 
        675                 680                 685             


<210>  588
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AOC1__Homo_sapiens__XP_011514310

<400>  588

Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr 
1               5                   10                  15      


Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val 
            20                  25                  30          


Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu 
        35                  40                  45              


Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met 
    50                  55                  60                  


Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr 
65                  70                  75                  80  


His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu 
                85                  90                  95      


Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr 
            100                 105                 110         


Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu 
        115                 120                 125             


Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser 
    130                 135                 140                 


Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys 
145                 150                 155                 160 


Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp 
                165                 170                 175     


Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val 
            180                 185                 190         


Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu 
        195                 200                 205             


Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly 
    210                 215                 220                 


Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly 
225                 230                 235                 240 


Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly 
                245                 250                 255     


Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly 
            260                 265                 270         


His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg 
        275                 280                 285             


Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln 
    290                 295                 300                 


Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly 
305                 310                 315                 320 


Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Ser Gly Leu Gln Val 
                325                 330                 335     


Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val 
            340                 345                 350         


Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln 
        355                 360                 365             


Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu 
    370                 375                 380                 


Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr 
385                 390                 395                 400 


Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu 
                405                 410                 415     


Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn 
            420                 425                 430         


Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln 
        435                 440                 445             


Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile 
    450                 455                 460                 


Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His 
465                 470                 475                 480 


Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg 
                485                 490                 495     


His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His 
            500                 505                 510         


Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser 
        515                 520                 525             


Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser 
    530                 535                 540                 


Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser 
545                 550                 555                 560 


Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr 
                565                 570                 575     


Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Thr 
            580                 585                 590         


Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly 
        595                 600                 605             


Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Thr Glu Gly Gly Gln 
    610                 615                 620                 


Pro Arg Ala Leu Ser Gln Ala Ala Ser Pro Val Pro Gly Arg Tyr Pro 
625                 630                 635                 640 


Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile 
                645                 650                 655     


Tyr His Gln Asn Asp Pro Trp His Pro Pro Val Val Phe Glu Gln Phe 
            660                 665                 670         


Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val 
        675                 680                 685             


Thr Val Gly Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr 
    690                 695                 700                 


Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe 
705                 710                 715                 720 


Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp 
                725                 730                 735     


Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp 
            740                 745                 750         


Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg 
        755                 760                 765             


Pro Val 
    770 


<210>  589
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AOC2__Homo_sapiens__NP_001149

<400>  589

Met His Leu Lys Ile Val Leu Ala Phe Leu Ala Leu Ser Leu Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Ala Tyr Val Leu Leu Thr Ser Pro Gly Gly Ser Ser 
            20                  25                  30          


Gln Pro Pro His Cys Pro Ser Val Ser His Arg Ala Gln Pro Trp Pro 
        35                  40                  45              


His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser Arg Glu Glu Leu 
    50                  55                  60                  


Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly Pro Gly Leu Val 
65                  70                  75                  80  


Asp Ala Ala Gln Ala Gln Pro Ser Asp Asn Cys Ile Phe Ser Val Glu 
                85                  90                  95      


Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His Leu Asp Arg Gly 
            100                 105                 110         


Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val Leu Phe Gly Gly 
        115                 120                 125             


Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly Pro Leu Pro His 
    130                 135                 140                 


Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His Gly Gly Pro Leu 
145                 150                 155                 160 


Pro Tyr His Arg Arg Pro Val Leu Arg Ala Glu Phe Thr Gln Met Trp 
                165                 170                 175     


Arg His Leu Lys Glu Val Glu Leu Pro Lys Ala Pro Ile Phe Leu Ser 
            180                 185                 190         


Ser Thr Phe Asn Tyr Asn Gly Ser Thr Leu Ala Ala Val His Ala Thr 
        195                 200                 205             


Pro Arg Gly Leu Arg Ser Gly Asp Arg Ala Thr Trp Met Ala Leu Tyr 
    210                 215                 220                 


His Asn Ile Ser Gly Val Gly Leu Phe Leu His Pro Val Gly Leu Glu 
225                 230                 235                 240 


Leu Leu Leu Asp His Arg Ala Leu Asp Pro Ala His Trp Thr Val Gln 
                245                 250                 255     


Gln Val Phe Tyr Leu Gly His Tyr Tyr Ala Asp Leu Gly Gln Leu Glu 
            260                 265                 270         


Arg Glu Phe Lys Ser Gly Arg Leu Glu Val Val Arg Val Pro Leu Pro 
        275                 280                 285             


Pro Pro Asn Gly Ala Ser Ser Leu Arg Ser Arg Asn Ser Pro Gly Pro 
    290                 295                 300                 


Leu Pro Pro Leu Gln Phe Ser Pro Gln Gly Ser Gln Tyr Ser Val Gln 
305                 310                 315                 320 


Gly Asn Leu Val Val Ser Ser Leu Trp Ser Phe Thr Phe Gly His Gly 
                325                 330                 335     


Val Phe Ser Gly Leu Arg Ile Phe Asp Val Arg Phe Gln Gly Glu Arg 
            340                 345                 350         


Ile Ala Tyr Glu Val Ser Val Gln Glu Cys Val Ser Ile Tyr Gly Ala 
        355                 360                 365             


Asp Ser Pro Lys Thr Met Leu Thr Arg Tyr Leu Asp Ser Ser Phe Gly 
    370                 375                 380                 


Leu Gly Arg Asn Ser Arg Gly Leu Val Arg Gly Val Asp Cys Pro Tyr 
385                 390                 395                 400 


Gln Ala Thr Met Val Asp Ile His Ile Leu Val Gly Lys Gly Ala Val 
                405                 410                 415     


Gln Leu Leu Pro Gly Ala Val Cys Val Phe Glu Glu Ala Gln Gly Leu 
            420                 425                 430         


Pro Leu Arg Arg His His Asn Tyr Leu Gln Asn His Phe Tyr Gly Gly 
        435                 440                 445             


Leu Ala Ser Ser Ala Leu Val Val Arg Ser Val Ser Ser Val Gly Asn 
    450                 455                 460                 


Tyr Asp Tyr Ile Trp Asp Phe Val Leu Tyr Pro Asn Gly Ala Leu Glu 
465                 470                 475                 480 


Gly Arg Val His Ala Thr Gly Tyr Ile Asn Thr Ala Phe Leu Lys Gly 
                485                 490                 495     


Gly Glu Glu Gly Leu Leu Phe Gly Asn Arg Val Gly Glu Arg Val Leu 
            500                 505                 510         


Gly Thr Val His Thr His Ala Phe His Phe Lys Leu Asp Leu Asp Val 
        515                 520                 525             


Ala Gly Leu Lys Asn Trp Val Val Ala Glu Asp Val Val Phe Lys Pro 
    530                 535                 540                 


Val Ala Ala Pro Trp Asn Pro Glu His Trp Leu Gln Arg Pro Gln Leu 
545                 550                 555                 560 


Thr Arg Gln Val Leu Gly Lys Glu Asp Leu Thr Ala Phe Ser Leu Gly 
                565                 570                 575     


Ser Pro Leu Pro Arg Tyr Leu Tyr Leu Ala Ser Asn Gln Thr Asn Ala 
            580                 585                 590         


Trp Gly His Gln Arg Gly Tyr Gln Leu Val Val Thr Gln Arg Lys Glu 
        595                 600                 605             


Glu Glu Ser Gln Ser Ser Ser Ile Tyr His Gln Asn Asp Ile Trp Thr 
    610                 615                 620                 


Pro Thr Val Thr Phe Ala Asp Phe Ile Asn Asn Glu Thr Leu Leu Gly 
625                 630                 635                 640 


Glu Asp Leu Val Ala Trp Val Thr Ala Ser Phe Leu His Ile Pro His 
                645                 650                 655     


Ala Glu Asp Ile Pro Asn Thr Val Thr Leu Gly Asn Arg Val Gly Phe 
            660                 665                 670         


Leu Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Ile Phe Ser 
        675                 680                 685             


Pro Gly Ser Val Tyr Phe Glu Lys Gly Gln Asp Ala Gly Leu Cys Ser 
    690                 695                 700                 


Ile Asn Pro Val Ala Cys Leu Pro Asp Leu Ala Ala Cys Val Pro Asp 
705                 710                 715                 720 


Leu Pro Pro Phe Ser Tyr His Gly Phe 
                725                 


<210>  590
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AOC3__Homo_sapiens__NP_003725

<400>  590

Met Asn Gln Lys Thr Ile Leu Val Leu Leu Ile Leu Ala Val Ile Thr 
1               5                   10                  15      


Ile Phe Ala Leu Val Cys Val Leu Leu Val Gly Arg Gly Gly Asp Gly 
            20                  25                  30          


Gly Glu Pro Ser Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala 
        35                  40                  45              


Gln Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser 
    50                  55                  60                  


Arg Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Arg Leu Gly 
65                  70                  75                  80  


Pro Gly Leu Val Asp Ala Ala Gln Ala Arg Pro Ser Asp Asn Cys Val 
                85                  90                  95      


Phe Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His 
            100                 105                 110         


Leu Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val 
        115                 120                 125             


Phe Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly 
    130                 135                 140                 


Pro Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His 
145                 150                 155                 160 


Gly Gly Pro Leu Pro Tyr His Arg Arg Pro Val Leu Phe Gln Glu Tyr 
                165                 170                 175     


Leu Asp Ile Asp Gln Met Ile Phe Asn Arg Glu Leu Pro Gln Ala Ser 
            180                 185                 190         


Gly Leu Leu His His Cys Cys Phe Tyr Lys His Arg Gly Arg Asn Leu 
        195                 200                 205             


Val Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala 
    210                 215                 220                 


Thr Trp Phe Gly Leu Tyr Tyr Asn Ile Ser Gly Ala Gly Phe Phe Leu 
225                 230                 235                 240 


His His Val Gly Leu Glu Leu Leu Val Asn His Lys Ala Leu Asp Pro 
                245                 250                 255     


Ala Arg Trp Thr Ile Gln Lys Val Phe Tyr Gln Gly Arg Tyr Tyr Asp 
            260                 265                 270         


Ser Leu Ala Gln Leu Glu Ala Gln Phe Glu Ala Gly Leu Val Asn Val 
        275                 280                 285             


Val Leu Ile Pro Asp Asn Gly Thr Gly Gly Ser Trp Ser Leu Lys Ser 
    290                 295                 300                 


Pro Val Pro Pro Gly Pro Ala Pro Pro Leu Gln Phe Tyr Pro Gln Gly 
305                 310                 315                 320 


Pro Arg Phe Ser Val Gln Gly Ser Arg Val Ala Ser Ser Leu Trp Thr 
                325                 330                 335     


Phe Ser Phe Gly Leu Gly Ala Phe Ser Gly Pro Arg Ile Phe Asp Val 
            340                 345                 350         


Arg Phe Gln Gly Glu Arg Leu Val Tyr Glu Ile Ser Leu Gln Glu Ala 
        355                 360                 365             


Leu Ala Ile Tyr Gly Gly Asn Ser Pro Ala Ala Met Thr Thr Arg Tyr 
    370                 375                 380                 


Val Asp Gly Gly Phe Gly Met Gly Lys Tyr Thr Thr Pro Leu Thr Arg 
385                 390                 395                 400 


Gly Val Asp Cys Pro Tyr Leu Ala Thr Tyr Val Asp Trp His Phe Leu 
                405                 410                 415     


Leu Glu Ser Gln Ala Pro Lys Thr Ile Arg Asp Ala Phe Cys Val Phe 
            420                 425                 430         


Glu Gln Asn Gln Gly Leu Pro Leu Arg Arg His His Ser Asp Leu Tyr 
        435                 440                 445             


Ser His Tyr Phe Gly Gly Leu Ala Glu Thr Val Leu Val Val Arg Ser 
    450                 455                 460                 


Met Ser Thr Leu Leu Asn Tyr Asp Tyr Val Trp Asp Thr Val Phe His 
465                 470                 475                 480 


Pro Ser Gly Ala Ile Glu Ile Arg Phe Tyr Ala Thr Gly Tyr Ile Ser 
                485                 490                 495     


Ser Ala Phe Leu Phe Gly Ala Thr Gly Lys Tyr Gly Asn Gln Val Ser 
            500                 505                 510         


Glu His Thr Leu Gly Thr Val His Thr His Ser Ala His Phe Lys Val 
        515                 520                 525             


Asp Leu Asp Val Ala Gly Leu Glu Asn Trp Val Trp Ala Glu Asp Met 
    530                 535                 540                 


Val Phe Val Pro Met Ala Val Pro Trp Ser Pro Glu His Gln Leu Gln 
545                 550                 555                 560 


Arg Leu Gln Val Thr Arg Lys Leu Leu Glu Met Glu Glu Gln Ala Ala 
                565                 570                 575     


Phe Leu Val Gly Ser Ala Thr Pro Arg Tyr Leu Tyr Leu Ala Ser Asn 
            580                 585                 590         


His Ser Asn Lys Trp Gly His Pro Arg Gly Tyr Arg Ile Gln Met Leu 
        595                 600                 605             


Ser Phe Ala Gly Glu Pro Leu Pro Gln Asn Ser Ser Met Ala Arg Gly 
    610                 615                 620                 


Phe Ser Trp Glu Arg Tyr Gln Leu Ala Val Thr Gln Arg Lys Glu Glu 
625                 630                 635                 640 


Glu Pro Ser Ser Ser Ser Val Phe Asn Gln Asn Asp Pro Trp Ala Pro 
                645                 650                 655     


Thr Val Asp Phe Ser Asp Phe Ile Asn Asn Glu Thr Ile Ala Gly Lys 
            660                 665                 670         


Asp Leu Val Ala Trp Val Thr Ala Gly Phe Leu His Ile Pro His Ala 
        675                 680                 685             


Glu Asp Ile Pro Asn Thr Val Thr Val Gly Asn Gly Val Gly Phe Phe 
    690                 695                 700                 


Leu Arg Pro Tyr Asn Phe Phe Asp Glu Asp Pro Ser Phe Tyr Ser Ala 
705                 710                 715                 720 


Asp Ser Ile Tyr Phe Arg Gly Asp Gln Asp Ala Gly Ala Cys Glu Val 
                725                 730                 735     


Asn Pro Leu Ala Cys Leu Pro Gln Ala Ala Ala Cys Ala Pro Asp Leu 
            740                 745                 750         


Pro Ala Phe Ser His Gly Gly Phe Ser His Asn 
        755                 760             


<210>  591
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AOX1__Homo_sapiens__NP_001150

<400>  591

Met Asp Arg Ala Ser Glu Leu Leu Phe Tyr Val Asn Gly Arg Lys Val 
1               5                   10                  15      


Ile Glu Lys Asn Val Asp Pro Glu Thr Met Leu Leu Pro Tyr Leu Arg 
            20                  25                  30          


Lys Lys Leu Arg Leu Thr Gly Thr Lys Tyr Gly Cys Gly Gly Gly Gly 
        35                  40                  45              


Cys Gly Ala Cys Thr Val Met Ile Ser Arg Tyr Asn Pro Ile Thr Lys 
    50                  55                  60                  


Arg Ile Arg His His Pro Ala Asn Ala Cys Leu Ile Pro Ile Cys Ser 
65                  70                  75                  80  


Leu Tyr Gly Ala Ala Val Thr Thr Val Glu Gly Ile Gly Ser Thr His 
                85                  90                  95      


Thr Arg Ile His Pro Val Gln Glu Arg Ile Ala Lys Cys His Gly Thr 
            100                 105                 110         


Gln Cys Gly Phe Cys Thr Pro Gly Met Val Met Ser Ile Tyr Thr Leu 
        115                 120                 125             


Leu Arg Asn His Pro Glu Pro Thr Leu Asp Gln Leu Thr Asp Ala Leu 
    130                 135                 140                 


Gly Gly Asn Leu Cys Arg Cys Thr Gly Tyr Arg Pro Ile Ile Asp Ala 
145                 150                 155                 160 


Cys Lys Thr Phe Cys Lys Thr Ser Gly Cys Cys Gln Ser Lys Glu Asn 
                165                 170                 175     


Gly Val Cys Cys Leu Asp Gln Gly Ile Asn Gly Leu Pro Glu Phe Glu 
            180                 185                 190         


Glu Gly Ser Lys Thr Ser Pro Lys Leu Phe Ala Glu Glu Glu Phe Leu 
        195                 200                 205             


Pro Leu Asp Pro Thr Gln Glu Leu Ile Phe Pro Pro Glu Leu Met Ile 
    210                 215                 220                 


Met Ala Glu Lys Gln Ser Gln Arg Thr Arg Val Phe Gly Ser Glu Arg 
225                 230                 235                 240 


Met Met Trp Phe Ser Pro Val Thr Leu Lys Glu Leu Leu Glu Phe Lys 
                245                 250                 255     


Phe Lys Tyr Pro Gln Ala Pro Val Ile Met Gly Asn Thr Ser Val Gly 
            260                 265                 270         


Pro Glu Val Lys Phe Lys Gly Val Phe His Pro Val Ile Ile Ser Pro 
        275                 280                 285             


Asp Arg Ile Glu Glu Leu Ser Val Val Asn His Ala Tyr Asn Gly Leu 
    290                 295                 300                 


Thr Leu Gly Ala Gly Leu Ser Leu Ala Gln Val Lys Asp Ile Leu Ala 
305                 310                 315                 320 


Asp Val Val Gln Lys Leu Pro Glu Glu Lys Thr Gln Met Tyr His Ala 
                325                 330                 335     


Leu Leu Lys His Leu Gly Thr Leu Ala Gly Ser Gln Ile Arg Asn Met 
            340                 345                 350         


Ala Ser Leu Gly Gly His Ile Ile Ser Arg His Pro Asp Ser Asp Leu 
        355                 360                 365             


Asn Pro Ile Leu Ala Val Gly Asn Cys Thr Leu Asn Leu Leu Ser Lys 
    370                 375                 380                 


Glu Gly Lys Arg Gln Ile Pro Leu Asn Glu Gln Phe Leu Ser Lys Cys 
385                 390                 395                 400 


Pro Asn Ala Asp Leu Lys Pro Gln Glu Ile Leu Val Ser Val Asn Ile 
                405                 410                 415     


Pro Tyr Ser Arg Lys Trp Glu Phe Val Ser Ala Phe Arg Gln Ala Gln 
            420                 425                 430         


Arg Gln Glu Asn Ala Leu Ala Ile Val Asn Ser Gly Met Arg Val Phe 
        435                 440                 445             


Phe Gly Glu Gly Asp Gly Ile Ile Arg Glu Leu Cys Ile Ser Tyr Gly 
    450                 455                 460                 


Gly Val Gly Pro Ala Thr Ile Cys Ala Lys Asn Ser Cys Gln Lys Leu 
465                 470                 475                 480 


Ile Gly Arg His Trp Asn Glu Gln Met Leu Asp Ile Ala Cys Arg Leu 
                485                 490                 495     


Ile Leu Asn Glu Val Ser Leu Leu Gly Ser Ala Pro Gly Gly Lys Val 
            500                 505                 510         


Glu Phe Lys Arg Thr Leu Ile Ile Ser Phe Leu Phe Lys Phe Tyr Leu 
        515                 520                 525             


Glu Val Ser Gln Ile Leu Lys Lys Met Asp Pro Val His Tyr Pro Ser 
    530                 535                 540                 


Leu Ala Asp Lys Tyr Glu Ser Ala Leu Glu Asp Leu His Ser Lys His 
545                 550                 555                 560 


His Cys Ser Thr Leu Lys Tyr Gln Asn Ile Gly Pro Lys Gln His Pro 
                565                 570                 575     


Glu Asp Pro Ile Gly His Pro Ile Met His Leu Ser Gly Val Lys His 
            580                 585                 590         


Ala Thr Gly Glu Ala Ile Tyr Cys Asp Asp Met Pro Leu Val Asp Gln 
        595                 600                 605             


Glu Leu Phe Leu Thr Phe Val Thr Ser Ser Arg Ala His Ala Lys Ile 
    610                 615                 620                 


Val Ser Ile Asp Leu Ser Glu Ala Leu Ser Met Pro Gly Val Val Asp 
625                 630                 635                 640 


Ile Met Thr Ala Glu His Leu Ser Asp Val Asn Ser Phe Cys Phe Phe 
                645                 650                 655     


Thr Glu Ala Glu Lys Phe Leu Ala Thr Asp Lys Val Phe Cys Val Gly 
            660                 665                 670         


Gln Leu Val Cys Ala Val Leu Ala Asp Ser Glu Val Gln Ala Lys Arg 
        675                 680                 685             


Ala Ala Lys Arg Val Lys Ile Val Tyr Gln Asp Leu Glu Pro Leu Ile 
    690                 695                 700                 


Leu Thr Ile Glu Glu Ser Ile Gln His Asn Ser Ser Phe Lys Pro Glu 
705                 710                 715                 720 


Arg Lys Leu Glu Tyr Gly Asn Val Asp Glu Ala Phe Lys Val Val Asp 
                725                 730                 735     


Gln Ile Leu Glu Gly Glu Ile His Met Gly Gly Gln Glu His Phe Tyr 
            740                 745                 750         


Met Glu Thr Gln Ser Met Leu Val Val Pro Lys Gly Glu Asp Gln Glu 
        755                 760                 765             


Met Asp Val Tyr Val Ser Thr Gln Phe Pro Lys Tyr Ile Gln Asp Ile 
    770                 775                 780                 


Val Ala Ser Thr Leu Lys Leu Pro Ala Asn Lys Val Met Cys His Val 
785                 790                 795                 800 


Arg Arg Val Gly Gly Ala Phe Gly Gly Lys Val Leu Lys Thr Gly Ile 
                805                 810                 815     


Ile Ala Ala Val Thr Ala Phe Ala Ala Asn Lys His Gly Arg Ala Val 
            820                 825                 830         


Arg Cys Val Leu Glu Arg Gly Glu Asp Met Leu Ile Thr Gly Gly Arg 
        835                 840                 845             


His Pro Tyr Leu Gly Lys Tyr Lys Ala Gly Phe Met Asn Asp Gly Arg 
    850                 855                 860                 


Ile Leu Ala Leu Asp Met Glu His Tyr Ser Asn Ala Gly Ala Ser Leu 
865                 870                 875                 880 


Asp Glu Ser Leu Phe Val Ile Glu Met Gly Leu Leu Lys Met Asp Asn 
                885                 890                 895     


Ala Tyr Lys Phe Pro Asn Leu Arg Cys Arg Gly Trp Ala Cys Arg Thr 
            900                 905                 910         


Asn Leu Pro Ser Asn Thr Ala Phe Arg Gly Phe Gly Phe Pro Gln Ala 
        915                 920                 925             


Ala Leu Ile Thr Glu Ser Cys Ile Thr Glu Val Ala Ala Lys Cys Gly 
    930                 935                 940                 


Leu Ser Pro Glu Lys Val Arg Ile Ile Asn Met Tyr Lys Glu Ile Asp 
945                 950                 955                 960 


Gln Thr Pro Tyr Lys Gln Glu Ile Asn Ala Lys Asn Leu Ile Gln Cys 
                965                 970                 975     


Trp Arg Glu Cys Met Ala Met Ser Ser Tyr Ser Leu Arg Lys Val Ala 
            980                 985                 990         


Val Glu Lys Phe Asn Ala Glu Asn  Tyr Trp Lys Lys Lys  Gly Leu Ala 
        995                 1000                 1005             


Met Val  Pro Leu Lys Phe Pro  Val Gly Leu Gly Ser  Arg Ala Ala 
    1010                 1015                 1020             


Gly Gln  Ala Ala Ala Leu Val  His Ile Tyr Leu Asp  Gly Ser Val 
    1025                 1030                 1035             


Leu Val  Thr His Gly Gly Ile  Glu Met Gly Gln Gly  Val His Thr 
    1040                 1045                 1050             


Lys Met  Ile Gln Val Val Ser  Arg Glu Leu Arg Met  Pro Met Ser 
    1055                 1060                 1065             


Asn Val  His Leu Arg Gly Thr  Ser Thr Glu Thr Val  Pro Asn Ala 
    1070                 1075                 1080             


Asn Ile  Ser Gly Gly Ser Val  Val Ala Asp Leu Asn  Gly Leu Ala 
    1085                 1090                 1095             


Val Lys  Asp Ala Cys Gln Thr  Leu Leu Lys Arg Leu  Glu Pro Ile 
    1100                 1105                 1110             


Ile Ser  Lys Asn Pro Lys Gly  Thr Trp Lys Asp Trp  Ala Gln Thr 
    1115                 1120                 1125             


Ala Phe  Asp Glu Ser Ile Asn  Leu Ser Ala Val Gly  Tyr Phe Arg 
    1130                 1135                 1140             


Gly Tyr  Glu Ser Asp Met Asn  Trp Glu Lys Gly Glu  Gly Gln Pro 
    1145                 1150                 1155             


Phe Glu  Tyr Phe Val Tyr Gly  Ala Ala Cys Ser Glu  Val Glu Ile 
    1160                 1165                 1170             


Asp Cys  Leu Thr Gly Asp His  Lys Asn Ile Arg Thr  Asp Ile Val 
    1175                 1180                 1185             


Met Asp  Val Gly Cys Ser Ile  Asn Pro Ala Ile Asp  Ile Gly Gln 
    1190                 1195                 1200             


Ile Glu  Gly Ala Phe Ile Gln  Gly Met Gly Leu Tyr  Thr Ile Glu 
    1205                 1210                 1215             


Glu Leu  Asn Tyr Ser Pro Gln  Gly Ile Leu His Thr  Arg Gly Pro 
    1220                 1225                 1230             


Asp Gln  Tyr Lys Ile Pro Ala  Ile Cys Asp Met Pro  Thr Glu Leu 
    1235                 1240                 1245             


His Ile  Ala Leu Leu Pro Pro  Ser Gln Asn Ser Asn  Thr Leu Tyr 
    1250                 1255                 1260             


Ser Ser  Lys Gly Leu Gly Glu  Ser Gly Val Phe Leu  Gly Cys Ser 
    1265                 1270                 1275             


Val Phe  Phe Ala Ile His Asp  Ala Val Ser Ala Ala  Arg Gln Glu 
    1280                 1285                 1290             


Arg Gly  Leu His Gly Pro Leu  Thr Leu Asn Ser Pro  Leu Thr Pro 
    1295                 1300                 1305             


Glu Lys  Ile Arg Met Ala Cys  Glu Asp Lys Phe Thr  Lys Met Ile 
    1310                 1315                 1320             


Pro Arg  Asp Glu Pro Gly Ser  Tyr Val Pro Trp Asn  Val Pro Ile 
    1325                 1330                 1335             


<210>  592
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1AR__Homo_sapiens__NP_001121898

<400>  592

Met Gly Asn Cys Cys Trp Thr Gln Cys Phe Gly Leu Leu Arg Lys Glu 
1               5                   10                  15      


Ala Gly Arg Leu Gln Arg Val Gly Gly Gly Gly Gly Ser Lys Tyr Phe 
            20                  25                  30          


Arg Thr Cys Ser Arg Gly Glu His Leu Thr Ile Glu Phe Glu Asn Leu 
        35                  40                  45              


Val Glu Ser Asp Glu Gly Glu Ser Pro Gly Ser Ser His Arg Pro Leu 
    50                  55                  60                  


Thr Glu Glu Glu Ile Val Asp Leu Arg Glu Arg His Tyr Asp Ser Ile 
65                  70                  75                  80  


Ala Glu Lys Gln Lys Asp Leu Asp Lys Lys Ile Gln Lys Glu Gln Glu 
                85                  90                  95      


Arg Gln Arg Ile Val Gln Gln Tyr His Pro Ser Asn Asn Gly Glu Tyr 
            100                 105                 110         


Gln Ser Ser Gly Pro Glu Asp Asp Phe Glu Ser Cys Leu Arg Asn Met 
        115                 120                 125             


Lys Ser Gln Tyr Glu Val Phe Arg Ser Ser Arg Leu Ser Ser Asp Ala 
    130                 135                 140                 


Thr Val Leu Thr Pro Asn Thr Glu Ser Ser Cys Asp Leu Met Thr Lys 
145                 150                 155                 160 


Thr Lys Ser Thr Ser Gly Asn Asp Asp Ser Thr Ser Leu Asp Leu Glu 
                165                 170                 175     


Trp Glu Asp Glu Glu Gly Met Asn Arg Met Leu Pro Met Arg Glu Arg 
            180                 185                 190         


Ser Lys Thr Glu Glu Asp Ile Leu Arg Ala Ala Leu Lys Tyr Ser Asn 
        195                 200                 205             


Lys Lys Thr Gly Ser Asn Pro Thr Ser Ala Ser Asp Asp Ser Asn Gly 
    210                 215                 220                 


Leu Glu Trp Glu Asn Asp Phe Val Ser Ala Glu Met Asp Asp Asn Gly 
225                 230                 235                 240 


Asn Ser Glu Tyr Ser Gly Phe Val Asn Pro Val Leu Glu Leu Ser Asp 
                245                 250                 255     


Ser Gly Ile Arg His Ser Asp Thr Asp Gln Gln Thr Arg 
            260                 265                 


<210>  593
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1B1__Homo_sapiens__NP_001159491

<400>  593

Met Thr Asp Ser Lys Tyr Phe Thr Thr Thr Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Ser Asp Lys Lys Glu Lys Lys Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ser Met Thr Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ala Leu Phe Pro Asp Val Val Asn Cys Met Gln Thr Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Thr Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Thr Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Thr Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Thr Ala Ala Val Cys 
    130                 135                 140                 


Val Ala Lys Leu His Asp Ile Asn Ala Gln Leu Val Glu Asp Gln Gly 
145                 150                 155                 160 


Phe Leu Asp Thr Leu Lys Asp Leu Ile Ser Asp Ser Asn Pro Met Val 
                165                 170                 175     


Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ala Glu Ser His Pro 
            180                 185                 190         


Ser Ser Asn Leu Leu Asp Leu Asn Pro Gln Ser Ile Asn Lys Leu Leu 
        195                 200                 205             


Thr Ala Leu Asn Glu Cys Thr Glu Trp Gly Gln Ile Phe Ile Leu Asp 
    210                 215                 220                 


Cys Leu Ala Asn Tyr Met Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
225                 230                 235                 240 


Cys Glu Arg Val Thr Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                245                 250                 255     


Leu Ser Ala Val Lys Val Leu Met Lys Phe Met Glu Met Leu Ser Lys 
            260                 265                 270         


Asp Leu Asp Tyr Tyr Gly Thr Leu Leu Lys Lys Leu Ala Pro Pro Leu 
        275                 280                 285             


Val Thr Leu Leu Ser Ala Glu Pro Glu Leu Gln Tyr Val Ala Leu Arg 
    290                 295                 300                 


Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys His Glu 
305                 310                 315                 320 


Met Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                325                 330                 335     


Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
            340                 345                 350         


Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Thr Glu Val Asp Val Asp 
        355                 360                 365             


Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
    370                 375                 380                 


Glu Gln Ser Ala Glu Arg Cys Val Ser Thr Leu Leu Asp Leu Ile Gln 
385                 390                 395                 400 


Thr Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Lys Asp 
                405                 410                 415     


Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Val Ile Ala Thr Leu 
            420                 425                 430         


Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Glu Ala Arg Ala Ala Met 
        435                 440                 445             


Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
    450                 455                 460                 


Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Thr Gln Val 
465                 470                 475                 480 


Gln Leu Gln Leu Leu Thr Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                485                 490                 495     


Thr Glu Thr Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Thr Gln 
            500                 505                 510         


Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
        515                 520                 525             


Leu Leu Ser Thr Asp Pro Val Ala Ala Lys Glu Val Val Leu Ala Glu 
    530                 535                 540                 


Lys Pro Leu Ile Ser Glu Glu Thr Asp Leu Ile Glu Pro Thr Leu Leu 
545                 550                 555                 560 


Asp Glu Leu Ile Cys Tyr Ile Gly Thr Leu Ala Ser Val Tyr His Lys 
                565                 570                 575     


Pro Pro Ser Ala Phe Val Glu Gly Gly Arg Gly Val Val His Lys Ser 
            580                 585                 590         


Leu Pro Pro Arg Thr Ala Ser Ser Glu Ser Ala Glu Ser Pro Glu Thr 
        595                 600                 605             


Ala Pro Thr Gly Ala Pro Pro Gly Glu Gln Pro Asp Val Ile Pro Ala 
    610                 615                 620                 


Gln Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro 
625                 630                 635                 640 


Val Ser Gly Pro Pro Leu Ala Thr Ser Ser Val Gln Met Gly Ala Val 
                645                 650                 655     


Asp Leu Leu Gly Gly Gly Leu Asp Ser Leu Ile Gly Gly Thr Asn Phe 
            660                 665                 670         


Val Ala Pro Pro Thr Ala Ala Val Pro Ala Asn Leu Gly Ala Pro Ile 
        675                 680                 685             


Gly Ser Gly Leu Ser Asp Leu Phe Asp Leu Thr Ser Gly Val Gly Thr 
    690                 695                 700                 


Leu Ser Gly Ser Tyr Val Ala Pro Lys Ala Val Gly Ser Ile Ser Met 
705                 710                 715                 720 


Asp Leu Gln Leu Thr Asn Lys Ala Leu Gln Val Met Thr Asp Phe Ala 
                725                 730                 735     


Ile Gln Phe Asn Arg Asn Ser Phe Gly Leu Ala Pro Ala Ala Pro Leu 
            740                 745                 750         


Gln Val His Ala Pro Leu Ser Pro Asn Gln Thr Val Glu Ile Ser Leu 
        755                 760                 765             


Pro Leu Ser Thr Val Gly Ser Val Met Lys Met Glu Pro Leu Asn Asn 
    770                 775                 780                 


Leu Gln Val Ala Val Lys Asn Asn Ile Asp Val Phe Tyr Phe Ser Thr 
785                 790                 795                 800 


Leu Tyr Pro Leu His Ile Leu Phe Val Glu Asp Gly Lys Met Asp Arg 
                805                 810                 815     


Gln Met Phe Leu Ala Thr Trp Lys Asp Ile Pro Asn Glu Asn Glu Ala 
            820                 825                 830         


Gln Phe Gln Ile Arg Asp Cys Pro Leu Asn Ala Glu Ala Ala Ser Ser 
        835                 840                 845             


Lys Leu Gln Ser Ser Asn Ile Phe Thr Val Ala Lys Arg Asn Val Glu 
    850                 855                 860                 


Gly Gln Asp Met Leu Tyr Gln Ser Leu Lys Leu Thr Asn Gly Ile Trp 
865                 870                 875                 880 


Val Leu Ala Glu Leu Arg Ile Gln Pro Gly Asn Pro Ser Cys Thr Leu 
                885                 890                 895     


Ser Leu Lys Cys Arg Ala Pro Glu Val Ser Gln His Val Tyr Gln Ala 
            900                 905                 910         


Tyr Glu Thr Ile Leu Lys Asn 
        915                 


<210>  594
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1G1__Homo_sapiens__NP_001025178

<400>  594

Met Pro Ala Pro Ile Arg Leu Arg Glu Leu Ile Arg Thr Ile Arg Thr 
1               5                   10                  15      


Ala Arg Thr Gln Ala Glu Glu Arg Glu Met Ile Gln Lys Glu Cys Ala 
            20                  25                  30          


Ala Ile Arg Ser Ser Phe Arg Glu Glu Asp Asn Thr Tyr Arg Cys Arg 
        35                  40                  45              


Asn Val Ala Lys Leu Leu Tyr Met His Met Leu Gly Tyr Pro Ala His 
    50                  55                  60                  


Phe Gly Gln Leu Glu Cys Leu Lys Leu Ile Ala Ser Gln Lys Phe Thr 
65                  70                  75                  80  


Asp Lys Arg Ile Gly Tyr Leu Gly Ala Met Leu Leu Leu Asp Glu Arg 
                85                  90                  95      


Gln Asp Val His Leu Leu Met Thr Asn Cys Ile Lys Asn Asp Leu Asn 
            100                 105                 110         


His Ser Thr Gln Phe Val Gln Gly Leu Ala Leu Cys Thr Leu Gly Cys 
        115                 120                 125             


Met Gly Ser Ser Glu Met Cys Arg Asp Leu Ala Gly Glu Val Glu Lys 
    130                 135                 140                 


Leu Leu Lys Thr Ser Asn Ser Tyr Leu Arg Lys Lys Ala Ala Leu Cys 
145                 150                 155                 160 


Ala Val His Val Ile Arg Lys Val Pro Glu Leu Met Glu Met Phe Leu 
                165                 170                 175     


Pro Ala Thr Lys Asn Leu Leu Asn Glu Lys Asn His Gly Val Leu His 
            180                 185                 190         


Thr Ser Val Val Leu Leu Thr Glu Met Cys Glu Arg Ser Pro Asp Met 
        195                 200                 205             


Leu Ala His Phe Arg Lys Asn Glu Lys Leu Val Pro Gln Leu Val Arg 
    210                 215                 220                 


Ile Leu Lys Asn Leu Ile Met Ser Gly Tyr Ser Pro Glu His Asp Val 
225                 230                 235                 240 


Ser Gly Ile Ser Asp Pro Phe Leu Gln Val Arg Ile Leu Arg Leu Leu 
                245                 250                 255     


Arg Ile Leu Gly Arg Asn Asp Asp Asp Ser Ser Glu Ala Met Asn Asp 
            260                 265                 270         


Ile Leu Ala Gln Val Ala Thr Asn Thr Glu Thr Ser Lys Asn Val Gly 
        275                 280                 285             


Asn Ala Ile Leu Tyr Glu Thr Val Leu Thr Ile Met Asp Ile Lys Ser 
    290                 295                 300                 


Glu Ser Gly Leu Arg Val Leu Ala Ile Asn Ile Leu Gly Arg Phe Leu 
305                 310                 315                 320 


Leu Asn Asn Asp Lys Asn Ile Arg Tyr Val Ala Leu Thr Ser Leu Leu 
                325                 330                 335     


Lys Thr Val Gln Thr Asp His Asn Ala Val Gln Arg His Arg Ser Thr 
            340                 345                 350         


Ile Val Asp Cys Leu Lys Asp Leu Asp Val Ser Ile Lys Arg Arg Ala 
        355                 360                 365             


Met Glu Leu Ser Phe Ala Leu Val Asn Gly Asn Asn Ile Arg Gly Met 
    370                 375                 380                 


Met Lys Glu Leu Leu Tyr Phe Leu Asp Ser Cys Glu Pro Glu Phe Lys 
385                 390                 395                 400 


Ala Asp Cys Ala Ser Gly Ile Phe Leu Ala Ala Glu Lys Tyr Ala Pro 
                405                 410                 415     


Ser Lys Arg Trp His Ile Asp Thr Ile Met Arg Val Leu Thr Thr Ala 
            420                 425                 430         


Gly Ser Tyr Val Arg Asp Asp Ala Val Pro Asn Leu Ile Gln Leu Ile 
        435                 440                 445             


Thr Asn Ser Val Glu Met His Ala Tyr Thr Val Gln Arg Leu Tyr Lys 
    450                 455                 460                 


Ala Ile Leu Gly Asp Tyr Ser Gln Gln Pro Leu Val Gln Val Ala Ala 
465                 470                 475                 480 


Trp Cys Ile Gly Glu Tyr Gly Asp Leu Leu Val Ser Gly Gln Cys Glu 
                485                 490                 495     


Glu Glu Glu Pro Ile Gln Val Thr Glu Asp Glu Val Leu Asp Ile Leu 
            500                 505                 510         


Glu Ser Val Leu Ile Ser Asn Met Ser Thr Ser Val Thr Arg Gly Tyr 
        515                 520                 525             


Ala Leu Thr Ala Ile Met Lys Leu Ser Thr Arg Phe Thr Cys Thr Val 
    530                 535                 540                 


Asn Arg Ile Lys Lys Val Val Ser Ile Tyr Gly Ser Ser Ile Asp Val 
545                 550                 555                 560 


Glu Leu Gln Gln Arg Ala Val Glu Tyr Asn Ala Leu Phe Lys Lys Tyr 
                565                 570                 575     


Asp His Met Arg Ser Ala Leu Leu Glu Arg Met Pro Val Met Glu Lys 
            580                 585                 590         


Val Thr Thr Asn Gly Pro Thr Glu Ile Val Gln Thr Asn Gly Glu Thr 
        595                 600                 605             


Glu Pro Ala Pro Leu Glu Thr Lys Pro Pro Pro Ser Gly Pro Gln Pro 
    610                 615                 620                 


Thr Ser Gln Ala Asn Asp Leu Leu Asp Leu Leu Gly Gly Asn Asp Ile 
625                 630                 635                 640 


Thr Pro Val Ile Pro Thr Ala Pro Thr Ser Lys Pro Ser Ser Ala Gly 
                645                 650                 655     


Gly Glu Leu Leu Asp Leu Leu Gly Asp Ile Asn Leu Thr Gly Ala Pro 
            660                 665                 670         


Ala Ala Ala Pro Ala Pro Ala Ser Val Pro Gln Ile Ser Gln Pro Pro 
        675                 680                 685             


Phe Leu Leu Asp Gly Leu Ser Ser Gln Pro Leu Phe Asn Asp Ile Ala 
    690                 695                 700                 


Ala Gly Ile Pro Ser Ile Thr Ala Tyr Ser Lys Asn Gly Leu Lys Ile 
705                 710                 715                 720 


Glu Phe Thr Phe Glu Arg Ser Asn Thr Asn Pro Ser Val Thr Val Ile 
                725                 730                 735     


Thr Ile Gln Ala Ser Asn Ser Thr Glu Leu Asp Met Thr Asp Phe Val 
            740                 745                 750         


Phe Gln Ala Ala Val Pro Lys Thr Phe Gln Leu Gln Leu Leu Ser Pro 
        755                 760                 765             


Ser Ser Ser Ile Val Pro Ala Phe Asn Thr Gly Thr Ile Thr Gln Val 
    770                 775                 780                 


Ile Lys Val Leu Asn Pro Gln Lys Gln Gln Leu Arg Met Arg Ile Lys 
785                 790                 795                 800 


Leu Thr Tyr Asn His Lys Gly Ser Ala Met Gln Asp Leu Ala Glu Val 
                805                 810                 815     


Asn Asn Phe Pro Pro Gln Ser Trp Gln 
            820                 825 


<210>  595
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1M1__Homo_sapiens__NP_001123996

<400>  595

Met Ser Ala Ser Ala Val Tyr Val Leu Asp Leu Lys Gly Lys Val Leu 
1               5                   10                  15      


Ile Cys Arg Asn Tyr Arg Gly Asp Val Asp Met Ser Glu Val Glu His 
            20                  25                  30          


Phe Met Pro Ile Leu Met Glu Lys Glu Glu Glu Gly Met Leu Ser Pro 
        35                  40                  45              


Ile Leu Ala His Gly Gly Val Arg Phe Met Trp Ile Lys His Asn Asn 
    50                  55                  60                  


Leu Tyr Leu Val Ala Thr Ser Lys Lys Asn Ala Cys Val Ser Leu Val 
65                  70                  75                  80  


Phe Ser Phe Leu Tyr Lys Val Val Gln Val Phe Ser Glu Tyr Phe Lys 
                85                  90                  95      


Glu Leu Glu Glu Glu Ser Ile Arg Asp Asn Phe Val Ile Ile Tyr Glu 
            100                 105                 110         


Leu Leu Asp Glu Leu Met Asp Phe Gly Tyr Pro Gln Thr Thr Asp Ser 
        115                 120                 125             


Lys Ile Leu Gln Glu Tyr Ile Thr Gln Glu Gly His Lys Leu Glu Thr 
    130                 135                 140                 


Gly Ala Pro Arg Pro Pro Ala Thr Val Thr Asn Ala Val Ser Trp Arg 
145                 150                 155                 160 


Ser Glu Gly Ile Lys Tyr Arg Lys Asn Glu Val Phe Leu Asp Val Ile 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Gly Lys Tyr Pro Gly Val Gly Trp Leu Gly 
            180                 185                 190         


His Thr Val Ser Ala Asn Gly Asn Val Leu Arg Ser Glu Ile Val Gly 
        195                 200                 205             


Ser Ile Lys Met Arg Val Phe Leu Ser Gly Met Pro Glu Leu Arg Leu 
    210                 215                 220                 


Gly Leu Asn Asp Lys Val Leu Phe Asp Asn Thr Gly Arg Gly Lys Ser 
225                 230                 235                 240 


Lys Ser Val Glu Leu Glu Asp Val Lys Phe His Gln Cys Val Arg Leu 
                245                 250                 255     


Ser Arg Phe Glu Asn Asp Arg Thr Ile Ser Phe Ile Pro Pro Asp Gly 
            260                 265                 270         


Glu Phe Glu Leu Met Ser Tyr Arg Leu Asn Thr His Val Lys Pro Leu 
        275                 280                 285             


Ile Trp Ile Glu Ser Val Ile Glu Lys His Ser His Ser Arg Ile Glu 
    290                 295                 300                 


Tyr Met Ile Lys Ala Lys Ser Gln Phe Lys Arg Arg Ser Thr Ala Asn 
305                 310                 315                 320 


Asn Val Glu Ile His Ile Pro Val Pro Asn Asp Ala Asp Ser Pro Lys 
                325                 330                 335     


Phe Lys Thr Thr Val Gly Ser Val Lys Trp Val Pro Glu Asn Ser Glu 
            340                 345                 350         


Ile Val Trp Ser Ile Lys Ser Phe Pro Gly Gly Lys Glu Tyr Leu Met 
        355                 360                 365             


Arg Ala His Phe Gly Leu Pro Ser Val Glu Ala Glu Asp Lys Glu Gly 
    370                 375                 380                 


Lys Pro Pro Ile Ser Val Lys Phe Glu Ile Pro Tyr Phe Thr Thr Ser 
385                 390                 395                 400 


Gly Ile Gln Val Arg Tyr Leu Lys Ile Ile Glu Lys Ser Gly Tyr Gln 
                405                 410                 415     


Ala Leu Pro Trp Val Arg Tyr Ile Thr Gln Asn Gly Asp Tyr Gln Leu 
            420                 425                 430         


Arg Thr Gln 
        435 


<210>  596
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1M2__Homo_sapiens__NP_005489

<400>  596

Met Ser Ala Ser Ala Val Phe Ile Leu Asp Val Lys Gly Lys Pro Leu 
1               5                   10                  15      


Ile Ser Arg Asn Tyr Lys Gly Asp Val Ala Met Ser Lys Ile Glu His 
            20                  25                  30          


Phe Met Pro Leu Leu Val Gln Arg Glu Glu Glu Gly Ala Leu Ala Pro 
        35                  40                  45              


Leu Leu Ser His Gly Gln Val His Phe Leu Trp Ile Lys His Ser Asn 
    50                  55                  60                  


Leu Tyr Leu Val Ala Thr Thr Ser Lys Asn Ala Asn Ala Ser Leu Val 
65                  70                  75                  80  


Tyr Ser Phe Leu Tyr Lys Thr Ile Glu Val Phe Cys Glu Tyr Phe Lys 
                85                  90                  95      


Glu Leu Glu Glu Glu Ser Ile Arg Asp Asn Phe Val Ile Val Tyr Glu 
            100                 105                 110         


Leu Leu Asp Glu Leu Met Asp Phe Gly Phe Pro Gln Thr Thr Asp Ser 
        115                 120                 125             


Lys Ile Leu Gln Glu Tyr Ile Thr Gln Gln Ser Asn Lys Leu Glu Thr 
    130                 135                 140                 


Gly Lys Ser Arg Val Pro Pro Thr Val Thr Asn Ala Val Ser Trp Arg 
145                 150                 155                 160 


Ser Glu Gly Ile Lys Tyr Lys Lys Asn Glu Val Phe Ile Asp Val Ile 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Val Asn Ala Asn Gly Ser Val Leu Leu Ser 
            180                 185                 190         


Glu Ile Val Gly Thr Ile Lys Leu Lys Val Phe Leu Ser Gly Met Pro 
        195                 200                 205             


Glu Leu Arg Leu Gly Leu Asn Asp Arg Val Leu Phe Glu Leu Thr Gly 
    210                 215                 220                 


Arg Ser Lys Asn Lys Ser Val Glu Leu Glu Asp Val Lys Phe His Gln 
225                 230                 235                 240 


Cys Val Arg Leu Ser Arg Phe Asp Asn Asp Arg Thr Ile Ser Phe Ile 
                245                 250                 255     


Pro Pro Asp Gly Asp Phe Glu Leu Met Ser Tyr Arg Leu Ser Thr Gln 
            260                 265                 270         


Val Lys Pro Leu Ile Trp Ile Glu Ser Val Ile Glu Lys Phe Ser His 
        275                 280                 285             


Ser Arg Val Glu Ile Met Val Lys Ala Lys Gly Gln Phe Lys Lys Gln 
    290                 295                 300                 


Ser Val Ala Asn Gly Val Glu Ile Ser Val Pro Val Pro Ser Asp Ala 
305                 310                 315                 320 


Asp Ser Pro Arg Phe Lys Thr Ser Val Gly Ser Ala Lys Tyr Val Pro 
                325                 330                 335     


Glu Arg Asn Val Val Ile Trp Ser Ile Lys Ser Phe Pro Gly Gly Lys 
            340                 345                 350         


Glu Tyr Leu Met Arg Ala His Phe Gly Leu Pro Ser Val Glu Lys Glu 
        355                 360                 365             


Glu Val Glu Gly Arg Pro Pro Ile Gly Val Lys Phe Glu Ile Pro Tyr 
    370                 375                 380                 


Phe Thr Val Ser Gly Ile Gln Val Arg Tyr Met Lys Ile Ile Glu Lys 
385                 390                 395                 400 


Ser Gly Tyr Gln Ala Leu Pro Trp Val Arg Tyr Ile Thr Gln Ser Gly 
                405                 410                 415     


Asp Tyr Gln Leu Arg Thr Ser 
            420             


<210>  597
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1S1__Homo_sapiens__NP_001274

<400>  597

Met Met Arg Phe Met Leu Leu Phe Ser Arg Gln Gly Lys Leu Arg Leu 
1               5                   10                  15      


Gln Lys Trp Tyr Leu Ala Thr Ser Asp Lys Glu Arg Lys Lys Met Val 
            20                  25                  30          


Arg Glu Leu Met Gln Val Val Leu Ala Arg Lys Pro Lys Met Cys Ser 
        35                  40                  45              


Phe Leu Glu Trp Arg Asp Leu Lys Val Val Tyr Lys Arg Tyr Ala Ser 
    50                  55                  60                  


Leu Tyr Phe Cys Cys Ala Ile Glu Gly Gln Asp Asn Glu Leu Ile Thr 
65                  70                  75                  80  


Leu Glu Leu Ile His Arg Tyr Val Glu Leu Leu Asp Lys Tyr Phe Gly 
                85                  90                  95      


Ser Val Cys Glu Leu Asp Ile Ile Phe Asn Phe Glu Lys Ala Tyr Phe 
            100                 105                 110         


Ile Leu Asp Glu Phe Leu Met Gly Gly Asp Val Gln Asp Thr Ser Lys 
        115                 120                 125             


Lys Ser Val Leu Lys Ala Ile Glu Gln Ala Asp Leu Leu Gln Glu Glu 
    130                 135                 140                 


Asp Glu Ser Pro Arg Ser Val Leu Glu Glu Met Gly Leu Ala 
145                 150                 155             


<210>  598
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1S2__Homo_sapiens__NP_001259000

<400>  598

Met Gln Phe Met Leu Leu Phe Ser Arg Gln Gly Lys Leu Arg Leu Gln 
1               5                   10                  15      


Lys Trp Tyr Val Pro Leu Ser Asp Lys Glu Lys Lys Lys Ile Thr Arg 
            20                  25                  30          


Glu Leu Val Gln Thr Val Leu Ala Arg Lys Pro Lys Met Cys Ser Phe 
        35                  40                  45              


Leu Glu Trp Arg Asp Leu Lys Ile Val Tyr Lys Arg Tyr Ala Ser Leu 
    50                  55                  60                  


Tyr Phe Cys Cys Ala Ile Glu Asp Gln Asp Asn Glu Leu Ile Thr Leu 
65                  70                  75                  80  


Glu Ile Ile His Arg Tyr Val Glu Leu Leu Asp Lys Tyr Phe Gly Ser 
                85                  90                  95      


Val Cys Glu Leu Asp Ile Ile Phe Asn Phe Glu Lys Ala Tyr Phe Ile 
            100                 105                 110         


Leu Asp Glu Phe Leu Leu Gly Gly Glu Val Gln Glu Thr Ser Lys Lys 
        115                 120                 125             


Asn Val Leu Lys Ala Ile Glu Gln Ala Asp Leu Leu Gln Glu Asp Ala 
    130                 135                 140                 


Lys Glu Ala Glu Thr Pro Arg Ser Val Leu Glu Glu Ile Gly Leu Thr 
145                 150                 155                 160 


<210>  599
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP1S3__Homo_sapiens__NP_001034658

<400>  599

Met Ile His Phe Ile Leu Leu Phe Ser Arg Gln Gly Lys Leu Arg Leu 
1               5                   10                  15      


Gln Lys Trp Tyr Ile Thr Leu Pro Asp Lys Glu Arg Lys Lys Ile Thr 
            20                  25                  30          


Arg Glu Ile Val Gln Ile Ile Leu Ser Arg Gly His Arg Thr Ser Ser 
        35                  40                  45              


Phe Val Asp Trp Lys Glu Leu Lys Leu Val Tyr Lys Arg Tyr Ala Ser 
    50                  55                  60                  


Leu Tyr Phe Cys Cys Ala Ile Glu Asn Gln Asp Asn Glu Leu Leu Thr 
65                  70                  75                  80  


Leu Glu Ile Val His Arg Tyr Val Glu Leu Leu Asp Lys Tyr Phe Gly 
                85                  90                  95      


Asn Val Cys Glu Leu Asp Ile Ile Phe Asn Phe Glu Lys Ala Tyr Phe 
            100                 105                 110         


Ile Leu Asp Glu Phe Ile Ile Gly Gly Glu Ile Gln Glu Thr Ser Lys 
        115                 120                 125             


Lys Ile Ala Val Lys Ala Ile Glu Asp Ser Asp Met Leu Gln Glu Thr 
    130                 135                 140                 


Met Glu Glu Tyr Met Asn Lys Pro Thr Phe 
145                 150                 


<210>  600
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP2A1__Homo_sapiens__NP_055018

<400>  600

Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Lys Tyr Thr Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Thr Phe Met 
        115                 120                 125             


Cys Leu Ala Leu His Cys Ile Ala Asn Val Gly Ser Arg Glu Met Gly 
    130                 135                 140                 


Glu Ala Phe Ala Ala Asp Ile Pro Arg Ile Leu Val Ala Gly Asp Ser 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Lys Ala Ser Pro Asp Leu Val Pro Met Gly Glu Trp Thr Ala Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Met Gly Val Val Thr Ala Ala Val 
        195                 200                 205             


Ser Leu Ile Thr Cys Leu Cys Lys Lys Asn Pro Asp Asp Phe Lys Thr 
    210                 215                 220                 


Cys Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Ser Ser Ala 
225                 230                 235                 240 


Ser Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Glu 
            260                 265                 270         


Asp Ala Ala Val Lys Gly Arg Leu Val Glu Cys Leu Glu Thr Val Leu 
        275                 280                 285             


Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn 
    290                 295                 300                 


Ala Lys Asn Ala Ile Leu Phe Glu Thr Ile Ser Leu Ile Ile His Tyr 
305                 310                 315                 320 


Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 
                325                 330                 335     


Phe Leu Gln His Arg Glu Thr Asn Leu Arg Tyr Leu Ala Leu Glu Ser 
            340                 345                 350         


Met Cys Thr Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Thr 
        355                 360                 365             


His Ile Asp Thr Val Ile Asn Ala Leu Lys Thr Glu Arg Asp Val Ser 
    370                 375                 380                 


Val Arg Gln Arg Ala Ala Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser 
385                 390                 395                 400 


Asn Ala Lys Gln Ile Val Ser Glu Met Leu Arg Tyr Leu Glu Thr Ala 
                405                 410                 415     


Asp Tyr Ala Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala 
            420                 425                 430         


Glu Lys Tyr Ala Val Asp Tyr Ser Trp Tyr Val Asp Thr Ile Leu Asn 
        435                 440                 445             


Leu Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg 
    450                 455                 460                 


Val Leu Gln Ile Val Thr Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala 
465                 470                 475                 480 


Lys Thr Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Met 
                485                 490                 495     


Val Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala 
            500                 505                 510         


Gly Asp Pro Arg Ser Ser Pro Pro Val Gln Phe Ser Leu Leu His Ser 
        515                 520                 525             


Lys Phe His Leu Cys Ser Val Ala Thr Arg Ala Leu Leu Leu Ser Thr 
    530                 535                 540                 


Tyr Ile Lys Phe Ile Asn Leu Phe Pro Glu Thr Lys Ala Thr Ile Gln 
545                 550                 555                 560 


Gly Val Leu Arg Ala Gly Ser Gln Leu Arg Asn Ala Asp Val Glu Leu 
                565                 570                 575     


Gln Gln Arg Ala Val Glu Tyr Leu Thr Leu Ser Ser Val Ala Ser Thr 
            580                 585                 590         


Asp Val Leu Ala Thr Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg 
        595                 600                 605             


Glu Ser Ser Ile Leu Ala Lys Leu Lys Arg Lys Lys Gly Pro Gly Ala 
    610                 615                 620                 


Gly Ser Ala Leu Asp Asp Gly Arg Arg Asp Pro Ser Ser Asn Asp Ile 
625                 630                 635                 640 


Asn Gly Gly Met Glu Pro Thr Pro Ser Thr Val Ser Thr Pro Ser Pro 
                645                 650                 655     


Ser Ala Asp Leu Leu Gly Leu Arg Ala Ala Pro Pro Pro Ala Ala Pro 
            660                 665                 670         


Pro Ala Ser Ala Gly Ala Gly Asn Leu Leu Val Asp Val Phe Asp Gly 
        675                 680                 685             


Pro Ala Ala Gln Pro Ser Leu Gly Pro Thr Pro Glu Glu Ala Phe Leu 
    690                 695                 700                 


Ser Glu Leu Glu Pro Pro Ala Pro Glu Ser Pro Met Ala Leu Leu Ala 
705                 710                 715                 720 


Asp Pro Ala Pro Ala Ala Asp Pro Gly Pro Glu Asp Ile Gly Pro Pro 
                725                 730                 735     


Ile Pro Glu Ala Asp Glu Leu Leu Asn Lys Phe Val Cys Lys Asn Asn 
            740                 745                 750         


Gly Val Leu Phe Glu Asn Gln Leu Leu Gln Ile Gly Val Lys Ser Glu 
        755                 760                 765             


Phe Arg Gln Asn Leu Gly Arg Met Tyr Leu Phe Tyr Gly Asn Lys Thr 
    770                 775                 780                 


Ser Val Gln Phe Gln Asn Phe Ser Pro Thr Val Val His Pro Gly Asp 
785                 790                 795                 800 


Leu Gln Thr Gln Leu Ala Val Gln Thr Lys Arg Val Ala Ala Gln Val 
                805                 810                 815     


Asp Gly Gly Ala Gln Val Gln Gln Val Leu Asn Ile Glu Cys Leu Arg 
            820                 825                 830         


Asp Phe Leu Thr Pro Pro Leu Leu Ser Val Arg Phe Arg Tyr Gly Gly 
        835                 840                 845             


Ala Pro Gln Ala Leu Thr Leu Lys Leu Pro Val Thr Ile Asn Lys Phe 
    850                 855                 860                 


Phe Gln Pro Thr Glu Met Ala Ala Gln Asp Phe Phe Gln Arg Trp Lys 
865                 870                 875                 880 


Gln Leu Ser Leu Pro Gln Gln Glu Ala Gln Lys Ile Phe Lys Ala Asn 
                885                 890                 895     


His Pro Met Asp Ala Glu Val Thr Lys Ala Lys Leu Leu Gly Phe Gly 
            900                 905                 910         


Ser Ala Leu Leu Asp Asn Val Asp Pro Asn Pro Glu Asn Phe Val Gly 
        915                 920                 925             


Ala Gly Ile Ile Gln Thr Lys Ala Leu Gln Val Gly Cys Leu Leu Arg 
    930                 935                 940                 


Leu Glu Pro Asn Ala Gln Ala Gln Met Tyr Arg Leu Thr Leu Arg Thr 
945                 950                 955                 960 


Ser Lys Glu Pro Val Ser Arg His Leu Cys Glu Leu Leu Ala Gln Gln 
                965                 970                 975     


Phe 
    


<210>  601
<211>  951
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP2B1__Homo_sapiens__NP_001025177

<400>  601

Met Thr Asp Ser Lys Tyr Phe Thr Thr Asn Lys Lys Gly Glu Ile Phe 
1               5                   10                  15      


Glu Leu Lys Ala Glu Leu Asn Asn Glu Lys Lys Glu Lys Arg Lys Glu 
            20                  25                  30          


Ala Val Lys Lys Val Ile Ala Ala Met Thr Val Gly Lys Asp Val Ser 
        35                  40                  45              


Ser Leu Phe Pro Asp Val Val Asn Cys Met Gln Thr Asp Asn Leu Glu 
    50                  55                  60                  


Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln 
65                  70                  75                  80  


Pro Asp Met Ala Ile Met Ala Val Asn Ser Phe Val Lys Asp Cys Glu 
                85                  90                  95      


Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Thr Met Gly Cys 
            100                 105                 110         


Ile Arg Val Asp Lys Ile Thr Glu Tyr Leu Cys Glu Pro Leu Arg Lys 
        115                 120                 125             


Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Thr Ala Ala Val Cys 
    130                 135                 140                 


Val Ala Lys Leu His Asp Ile Asn Ala Gln Met Val Glu Asp Gln Gly 
145                 150                 155                 160 


Phe Leu Asp Ser Leu Arg Asp Leu Ile Ala Asp Ser Asn Pro Met Val 
                165                 170                 175     


Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ser Glu Ser His Pro 
            180                 185                 190         


Asn Ser Asn Leu Leu Asp Leu Asn Pro Gln Asn Ile Asn Lys Leu Leu 
        195                 200                 205             


Thr Ala Leu Asn Glu Cys Thr Glu Trp Gly Gln Ile Phe Ile Leu Asp 
    210                 215                 220                 


Cys Leu Ser Asn Tyr Asn Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile 
225                 230                 235                 240 


Cys Glu Arg Val Thr Pro Arg Leu Ser His Ala Asn Ser Ala Val Val 
                245                 250                 255     


Leu Ser Ala Val Lys Val Leu Met Lys Phe Leu Glu Leu Leu Pro Lys 
            260                 265                 270         


Asp Ser Asp Tyr Tyr Asn Met Leu Leu Lys Lys Leu Ala Pro Pro Leu 
        275                 280                 285             


Val Thr Leu Leu Ser Gly Glu Pro Glu Val Gln Tyr Val Ala Leu Arg 
    290                 295                 300                 


Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys Gln Glu 
305                 310                 315                 320 


Ile Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu 
                325                 330                 335     


Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala 
            340                 345                 350         


Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Thr Glu Val Asp Val Asp 
        355                 360                 365             


Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val 
    370                 375                 380                 


Glu Gln Ser Ala Glu Arg Cys Val Ser Thr Leu Leu Asp Leu Ile Gln 
385                 390                 395                 400 


Thr Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Arg Asp 
                405                 410                 415     


Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Ile Ile Ala Thr Leu 
            420                 425                 430         


Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Asp Ala Arg Ala Ala Met 
        435                 440                 445             


Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu 
    450                 455                 460                 


Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Thr Gln Val 
465                 470                 475                 480 


Gln Leu Thr Leu Leu Thr Ala Ile Val Lys Leu Phe Leu Lys Lys Pro 
                485                 490                 495     


Ser Glu Thr Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Thr Gln 
            500                 505                 510         


Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg 
        515                 520                 525             


Leu Leu Ser Thr Asp Pro Val Thr Ala Lys Glu Val Val Leu Ser Glu 
    530                 535                 540                 


Lys Pro Leu Ile Ser Glu Glu Thr Asp Leu Ile Glu Pro Thr Leu Leu 
545                 550                 555                 560 


Asp Glu Leu Ile Cys His Ile Gly Ser Leu Ala Ser Val Tyr His Lys 
                565                 570                 575     


Pro Pro Asn Ala Phe Val Glu Gly Ser His Gly Ile His Arg Lys His 
            580                 585                 590         


Leu Pro Ile His His Gly Ser Thr Asp Ala Gly Asp Ser Pro Val Gly 
        595                 600                 605             


Thr Thr Thr Ala Thr Asn Leu Glu Gln Pro Gln Val Ile Pro Ser Gln 
    610                 615                 620                 


Gly Asp Leu Leu Gly Asp Leu Leu Asn Leu Asp Leu Gly Pro Pro Val 
625                 630                 635                 640 


Asn Val Pro Gln Val Ser Ser Met Gln Met Gly Ala Val Asp Leu Leu 
                645                 650                 655     


Gly Gly Gly Leu Asp Ser Leu Leu Gly Ser Asp Leu Gly Gly Gly Ile 
            660                 665                 670         


Gly Gly Ser Pro Ala Val Gly Gln Ser Phe Ile Pro Ser Ser Val Pro 
        675                 680                 685             


Ala Thr Phe Ala Pro Ser Pro Thr Pro Ala Val Val Ser Ser Gly Leu 
    690                 695                 700                 


Asn Asp Leu Phe Glu Leu Ser Thr Gly Ile Gly Met Ala Pro Gly Gly 
705                 710                 715                 720 


Tyr Val Ala Pro Lys Ala Val Trp Leu Pro Ala Val Lys Ala Lys Gly 
                725                 730                 735     


Leu Glu Ile Ser Gly Thr Phe Thr His Arg Gln Gly His Ile Tyr Met 
            740                 745                 750         


Glu Met Asn Phe Thr Asn Lys Ala Leu Gln His Met Thr Asp Phe Ala 
        755                 760                 765             


Ile Gln Phe Asn Lys Asn Ser Phe Gly Val Ile Pro Ser Thr Pro Leu 
    770                 775                 780                 


Ala Ile His Thr Pro Leu Met Pro Asn Gln Ser Ile Asp Val Ser Leu 
785                 790                 795                 800 


Pro Leu Asn Thr Leu Gly Pro Val Met Lys Met Glu Pro Leu Asn Asn 
                805                 810                 815     


Leu Gln Val Ala Val Lys Asn Asn Ile Asp Val Phe Tyr Phe Ser Cys 
            820                 825                 830         


Leu Ile Pro Leu Asn Val Leu Phe Val Glu Asp Gly Lys Met Glu Arg 
        835                 840                 845             


Gln Val Phe Leu Ala Thr Trp Lys Asp Ile Pro Asn Glu Asn Glu Leu 
    850                 855                 860                 


Gln Phe Gln Ile Lys Glu Cys His Leu Asn Ala Asp Thr Val Ser Ser 
865                 870                 875                 880 


Lys Leu Gln Asn Asn Asn Val Tyr Thr Ile Ala Lys Arg Asn Val Glu 
                885                 890                 895     


Gly Gln Asp Met Leu Tyr Gln Ser Leu Lys Leu Thr Asn Gly Ile Trp 
            900                 905                 910         


Ile Leu Ala Glu Leu Arg Ile Gln Pro Gly Asn Pro Asn Tyr Thr Leu 
        915                 920                 925             


Ser Leu Lys Cys Arg Ala Pro Glu Val Ser Gln Tyr Ile Tyr Gln Val 
    930                 935                 940                 


Tyr Asp Ser Ile Leu Lys Asn 
945                 950     


<210>  602
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP2M1__Homo_sapiens__NP_001020376

<400>  602

Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile 
1               5                   10                  15      


Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe 
            20                  25                  30          


Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Thr 
        35                  40                  45              


Asn Ile Ala Arg Thr Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp 
    50                  55                  60                  


Leu Ala Ala Val Thr Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu 
65                  70                  75                  80  


Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile 
                85                  90                  95      


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu 
            100                 105                 110         


Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Thr Gly Ala 
        115                 120                 125             


Leu Lys Thr Phe Ile Thr Gln Gln Gly Ile Lys Ser Gln Thr Lys Glu 
    130                 135                 140                 


Glu Gln Ser Gln Ile Thr Ser Gln Val Thr Gly Gln Ile Gly Trp Arg 
145                 150                 155                 160 


Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp Val Leu 
                165                 170                 175     


Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu Ser Ala 
            180                 185                 190         


His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly Met Pro 
        195                 200                 205             


Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys Gln Gly 
    210                 215                 220                 


Lys Gly Thr Ala Asp Glu Thr Ser Lys Ser Gly Lys Gln Ser Ile Ala 
225                 230                 235                 240 


Ile Asp Asp Cys Thr Phe His Gln Cys Val Arg Leu Ser Lys Phe Asp 
                245                 250                 255     


Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe Glu Leu 
            260                 265                 270         


Met Arg Tyr Arg Thr Thr Lys Asp Ile Ile Leu Pro Phe Arg Val Ile 
        275                 280                 285             


Pro Leu Val Arg Glu Val Gly Arg Thr Lys Leu Glu Val Lys Val Val 
    290                 295                 300                 


Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile Glu Val 
305                 310                 315                 320 


Arg Ile Pro Thr Pro Leu Asn Thr Ser Gly Val Gln Val Ile Cys Met 
                325                 330                 335     


Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val Trp Lys 
            340                 345                 350         


Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala Glu Ile 
        355                 360                 365             


Glu Leu Leu Pro Thr Asn Asp Lys Lys Lys Trp Ala Arg Pro Pro Ile 
    370                 375                 380                 


Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys Val Arg 
385                 390                 395                 400 


Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His Asp Val 
                405                 410                 415     


Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu Thr Arg 
            420                 425                 430         


Cys 
    


<210>  603
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP2S1__Homo_sapiens__NP_004060

<400>  603

Met Ile Arg Phe Ile Leu Ile Gln Asn Arg Ala Gly Lys Thr Arg Leu 
1               5                   10                  15      


Ala Lys Trp Tyr Met Gln Phe Asp Asp Asp Glu Lys Gln Lys Leu Ile 
            20                  25                  30          


Glu Glu Val His Ala Val Val Thr Val Arg Asp Ala Lys His Thr Asn 
        35                  40                  45              


Phe Val Glu Phe Arg Asn Phe Lys Ile Ile Tyr Arg Arg Tyr Ala Gly 
    50                  55                  60                  


Leu Tyr Phe Cys Ile Cys Val Asp Val Asn Asp Asn Asn Leu Ala Tyr 
65                  70                  75                  80  


Leu Glu Ala Ile His Asn Phe Val Glu Val Leu Asn Glu Tyr Phe His 
                85                  90                  95      


Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe Tyr Lys Val Tyr Thr 
            100                 105                 110         


Val Val Asp Glu Met Phe Leu Ala Gly Glu Ile Arg Glu Thr Ser Gln 
        115                 120                 125             


Thr Lys Val Leu Lys Gln Leu Leu Met Leu Gln Ser Leu Glu 
    130                 135                 140         


<210>  604
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP3B1__Homo_sapiens__NP_001258698

<400>  604

Met Leu Glu Ser Asn Lys Asp Ser Ala Lys Leu Asp Ala Met Lys Arg 
1               5                   10                  15      


Ile Val Gly Met Ile Ala Lys Gly Lys Asn Ala Ser Glu Leu Phe Pro 
            20                  25                  30          


Ala Val Val Lys Asn Val Ala Ser Lys Asn Ile Glu Ile Lys Lys Leu 
        35                  40                  45              


Val Tyr Val Tyr Leu Val Arg Tyr Ala Glu Glu Gln Gln Asp Leu Ala 
    50                  55                  60                  


Leu Leu Ser Ile Ser Thr Phe Gln Arg Ala Leu Lys Asp Pro Asn Gln 
65                  70                  75                  80  


Leu Ile Arg Ala Ser Ala Leu Arg Val Leu Ser Ser Ile Arg Val Pro 
                85                  90                  95      


Ile Ile Val Pro Ile Met Met Leu Ala Ile Lys Glu Ala Ser Ala Asp 
            100                 105                 110         


Leu Ser Pro Tyr Val Arg Lys Asn Ala Ala His Ala Ile Gln Lys Leu 
        115                 120                 125             


Tyr Ser Leu Asp Pro Glu Gln Lys Glu Met Leu Ile Glu Val Ile Glu 
    130                 135                 140                 


Lys Leu Leu Lys Asp Lys Ser Thr Leu Val Ala Gly Ser Val Val Met 
145                 150                 155                 160 


Ala Phe Glu Glu Val Cys Pro Asp Arg Ile Asp Leu Ile His Lys Asn 
                165                 170                 175     


Tyr Arg Lys Leu Cys Asn Leu Leu Val Asp Val Glu Glu Trp Gly Gln 
            180                 185                 190         


Val Val Ile Ile His Met Leu Thr Arg Tyr Ala Arg Thr Gln Phe Val 
        195                 200                 205             


Ser Pro Trp Lys Glu Gly Asp Glu Leu Glu Asp Asn Gly Lys Asn Phe 
    210                 215                 220                 


Tyr Glu Ser Asp Asp Asp Gln Lys Glu Lys Thr Asp Lys Lys Lys Lys 
225                 230                 235                 240 


Pro Tyr Thr Met Asp Pro Asp His Arg Leu Leu Ile Arg Asn Thr Lys 
                245                 250                 255     


Pro Leu Leu Gln Ser Arg Asn Ala Ala Val Val Met Ala Val Ala Gln 
            260                 265                 270         


Leu Tyr Trp His Ile Ser Pro Lys Ser Glu Ala Gly Ile Ile Ser Lys 
        275                 280                 285             


Ser Leu Val Arg Leu Leu Arg Ser Asn Arg Glu Val Gln Tyr Ile Val 
    290                 295                 300                 


Leu Gln Asn Ile Ala Thr Met Ser Ile Gln Arg Lys Gly Met Phe Glu 
305                 310                 315                 320 


Pro Tyr Leu Lys Ser Phe Tyr Val Arg Ser Thr Asp Pro Thr Met Ile 
                325                 330                 335     


Lys Thr Leu Lys Leu Glu Ile Leu Thr Asn Leu Ala Asn Glu Ala Asn 
            340                 345                 350         


Ile Ser Thr Leu Leu Arg Glu Phe Gln Thr Tyr Val Lys Ser Gln Asp 
        355                 360                 365             


Lys Gln Phe Ala Ala Ala Thr Ile Gln Thr Ile Gly Arg Cys Ala Thr 
    370                 375                 380                 


Asn Ile Leu Glu Val Thr Asp Thr Cys Leu Asn Gly Leu Val Cys Leu 
385                 390                 395                 400 


Leu Ser Asn Arg Asp Glu Ile Val Val Ala Glu Ser Val Val Val Ile 
                405                 410                 415     


Lys Lys Leu Leu Gln Met Gln Pro Ala Gln His Gly Glu Ile Ile Lys 
            420                 425                 430         


His Met Ala Lys Leu Leu Asp Ser Ile Thr Val Pro Val Ala Arg Ala 
        435                 440                 445             


Ser Ile Leu Trp Leu Ile Gly Glu Asn Cys Glu Arg Val Pro Lys Ile 
    450                 455                 460                 


Ala Pro Asp Val Leu Arg Lys Met Ala Lys Ser Phe Thr Ser Glu Asp 
465                 470                 475                 480 


Asp Leu Val Lys Leu Gln Ile Leu Asn Leu Gly Ala Lys Leu Tyr Leu 
                485                 490                 495     


Thr Asn Ser Lys Gln Thr Lys Leu Leu Thr Gln Tyr Ile Leu Asn Leu 
            500                 505                 510         


Gly Lys Tyr Asp Gln Asn Tyr Asp Ile Arg Asp Arg Thr Arg Phe Ile 
        515                 520                 525             


Arg Gln Leu Ile Val Pro Asn Val Lys Ser Gly Ala Leu Ser Lys Tyr 
    530                 535                 540                 


Ala Lys Lys Ile Phe Leu Ala Gln Lys Pro Ala Pro Leu Leu Glu Ser 
545                 550                 555                 560 


Pro Phe Lys Asp Arg Asp His Phe Gln Leu Gly Thr Leu Ser His Thr 
                565                 570                 575     


Leu Asn Ile Lys Ala Thr Gly Tyr Leu Glu Leu Ser Asn Trp Pro Glu 
            580                 585                 590         


Val Ala Pro Asp Pro Ser Val Arg Asn Val Glu Val Ile Glu Leu Ala 
        595                 600                 605             


Lys Glu Trp Thr Pro Ala Gly Lys Ala Lys Gln Glu Asn Ser Ala Lys 
    610                 615                 620                 


Lys Phe Tyr Ser Glu Ser Glu Glu Glu Glu Asp Ser Ser Asp Ser Ser 
625                 630                 635                 640 


Ser Asp Ser Glu Ser Glu Ser Gly Ser Glu Ser Gly Glu Gln Gly Glu 
                645                 650                 655     


Ser Gly Glu Glu Gly Asp Ser Asn Glu Asp Ser Ser Glu Asp Ser Ser 
            660                 665                 670         


Ser Glu Gln Asp Ser Glu Ser Gly Arg Glu Ser Gly Leu Glu Asn Lys 
        675                 680                 685             


Arg Thr Ala Lys Arg Asn Ser Lys Ala Lys Gly Lys Ser Asp Ser Glu 
    690                 695                 700                 


Asp Gly Glu Lys Glu Asn Glu Lys Ser Lys Thr Ser Asp Ser Ser Asn 
705                 710                 715                 720 


Asp Glu Ser Ser Ser Ile Glu Asp Ser Ser Ser Asp Ser Glu Ser Glu 
                725                 730                 735     


Ser Glu Pro Glu Ser Glu Ser Glu Ser Arg Arg Val Thr Lys Glu Lys 
            740                 745                 750         


Glu Lys Lys Thr Lys Gln Asp Arg Thr Pro Leu Thr Lys Asp Val Ser 
        755                 760                 765             


Leu Leu Asp Leu Asp Asp Phe Asn Pro Val Ser Thr Pro Val Ala Leu 
    770                 775                 780                 


Pro Thr Pro Ala Leu Ser Pro Ser Leu Met Ala Asp Leu Glu Gly Leu 
785                 790                 795                 800 


His Leu Ser Thr Ser Ser Ser Val Ile Ser Val Ser Thr Pro Ala Phe 
                805                 810                 815     


Val Pro Thr Lys Thr His Val Leu Leu His Arg Met Ser Gly Lys Gly 
            820                 825                 830         


Leu Ala Ala His Tyr Phe Phe Pro Arg Gln Pro Cys Ile Phe Gly Asp 
        835                 840                 845             


Lys Met Val Ser Ile Gln Ile Thr Leu Asn Asn Thr Thr Asp Arg Lys 
    850                 855                 860                 


Ile Glu Asn Ile His Ile Gly Glu Lys Lys Leu Pro Ile Gly Met Lys 
865                 870                 875                 880 


Met His Val Phe Asn Pro Ile Asp Ser Leu Glu Pro Glu Gly Ser Ile 
                885                 890                 895     


Thr Val Ser Met Gly Ile Asp Phe Cys Asp Ser Thr Gln Thr Ala Ser 
            900                 905                 910         


Phe Gln Leu Cys Thr Lys Asp Asp Cys Phe Asn Val Asn Ile Gln Pro 
        915                 920                 925             


Pro Val Gly Glu Leu Leu Leu Pro Val Ala Met Ser Glu Lys Asp Phe 
    930                 935                 940                 


Lys Lys Glu Gln Gly Val Leu Thr Gly Met Asn Glu Thr Ser Ala Val 
945                 950                 955                 960 


Ile Ile Ala Ala Pro Gln Asn Phe Thr Pro Ser Val Ile Phe Gln Lys 
                965                 970                 975     


Val Val Asn Val Ala Asn Val Gly Ala Val Pro Ser Gly Gln Asp Asn 
            980                 985                 990         


Ile His Arg Phe Ala Ala Lys Thr  Val His Ser Gly Ser  Leu Met Leu 
        995                 1000                 1005             


Val Thr  Val Glu Leu Lys Glu  Gly Ser Thr Ala Gln  Leu Ile Ile 
    1010                 1015                 1020             


Asn Thr  Glu Lys Thr Val Ile  Gly Ser Val Leu Leu  Arg Glu Leu 
    1025                 1030                 1035             


Lys Pro  Val Leu Ser Gln Gly  
    1040                 1045 


<210>  605
<211>  1215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP3D1__Homo_sapiens__NP_001248755

<400>  605

Met Ala Leu Lys Met Val Lys Gly Ser Ile Asp Arg Met Phe Asp Lys 
1               5                   10                  15      


Asn Leu Gln Asp Leu Val Arg Gly Ile Arg Asn His Lys Glu Asp Glu 
            20                  25                  30          


Ala Lys Tyr Ile Ser Gln Cys Ile Asp Glu Ile Lys Gln Glu Leu Lys 
        35                  40                  45              


Gln Asp Asn Ile Ala Val Lys Ala Asn Ala Val Cys Lys Leu Thr Tyr 
    50                  55                  60                  


Leu Gln Met Leu Gly Tyr Asp Ile Ser Trp Ala Ala Phe Asn Ile Ile 
65                  70                  75                  80  


Glu Val Met Ser Ala Ser Lys Phe Thr Phe Lys Arg Ile Gly Tyr Leu 
                85                  90                  95      


Ala Ala Ser Gln Ser Phe His Glu Gly Thr Asp Val Ile Met Leu Thr 
            100                 105                 110         


Thr Asn Gln Ile Arg Lys Asp Leu Ser Ser Pro Ser Gln Tyr Asp Thr 
        115                 120                 125             


Gly Val Ala Leu Thr Gly Leu Ser Cys Phe Val Thr Pro Asp Leu Ala 
    130                 135                 140                 


Arg Asp Leu Ala Asn Asp Ile Met Thr Leu Met Ser His Thr Lys Pro 
145                 150                 155                 160 


Tyr Ile Arg Lys Lys Ala Val Leu Ile Met Tyr Lys Val Phe Leu Lys 
                165                 170                 175     


Tyr Pro Glu Ser Leu Arg Pro Ala Phe Pro Arg Leu Lys Glu Lys Leu 
            180                 185                 190         


Glu Asp Pro Asp Pro Gly Val Gln Ser Ala Ala Val Asn Val Ile Cys 
        195                 200                 205             


Glu Leu Ala Arg Arg Asn Pro Lys Asn Tyr Leu Ser Leu Ala Pro Leu 
    210                 215                 220                 


Phe Phe Lys Leu Met Thr Ser Ser Thr Asn Asn Trp Val Leu Ile Lys 
225                 230                 235                 240 


Ile Ile Lys Leu Phe Gly Ala Leu Thr Pro Leu Glu Pro Arg Leu Gly 
                245                 250                 255     


Lys Lys Leu Ile Glu Pro Leu Thr Asn Leu Ile His Ser Thr Ser Ala 
            260                 265                 270         


Met Ser Leu Leu Tyr Glu Cys Val Asn Thr Val Ile Ala Val Leu Ile 
        275                 280                 285             


Ser Leu Ser Ser Gly Met Pro Asn His Ser Ala Ser Ile Gln Leu Cys 
    290                 295                 300                 


Val Gln Lys Leu Arg Ile Leu Ile Glu Asp Ser Asp Gln Asn Leu Lys 
305                 310                 315                 320 


Tyr Leu Gly Leu Leu Ala Met Ser Lys Ile Leu Lys Thr His Pro Lys 
                325                 330                 335     


Ser Val Gln Ser His Lys Asp Leu Ile Leu Gln Cys Leu Asp Asp Lys 
            340                 345                 350         


Asp Glu Ser Ile Arg Leu Arg Ala Leu Asp Leu Leu Tyr Gly Met Val 
        355                 360                 365             


Ser Lys Lys Asn Leu Met Glu Ile Val Lys Lys Leu Met Thr His Val 
    370                 375                 380                 


Asp Lys Ala Glu Gly Thr Thr Tyr Arg Asp Glu Leu Leu Thr Lys Ile 
385                 390                 395                 400 


Ile Asp Ile Cys Ser Gln Ser Asn Tyr Gln Tyr Ile Thr Asn Phe Glu 
                405                 410                 415     


Trp Tyr Ile Ser Ile Leu Val Glu Leu Thr Arg Leu Glu Gly Thr Arg 
            420                 425                 430         


His Gly His Leu Ile Ala Ala Gln Met Leu Asp Val Ala Ile Arg Val 
        435                 440                 445             


Lys Ala Ile Arg Lys Phe Ala Val Ser Gln Met Ser Ala Leu Leu Asp 
    450                 455                 460                 


Ser Ala His Leu Leu Ala Ser Ser Thr Gln Arg Asn Gly Ile Cys Glu 
465                 470                 475                 480 


Val Leu Tyr Ala Ala Ala Trp Ile Cys Gly Glu Phe Ser Glu His Leu 
                485                 490                 495     


Gln Glu Pro His His Thr Leu Glu Ala Met Leu Arg Pro Arg Val Thr 
            500                 505                 510         


Thr Leu Pro Gly His Ile Gln Ala Val Tyr Val Gln Asn Val Val Lys 
        515                 520                 525             


Leu Tyr Ala Ser Ile Leu Gln Gln Lys Glu Gln Ala Gly Glu Ala Glu 
    530                 535                 540                 


Gly Ala Gln Ala Val Thr Gln Leu Met Val Asp Arg Leu Pro Gln Phe 
545                 550                 555                 560 


Val Gln Ser Ala Asp Leu Glu Val Gln Glu Arg Ala Ser Cys Ile Leu 
                565                 570                 575     


Gln Leu Val Lys His Ile Gln Lys Leu Gln Ala Lys Asp Val Pro Val 
            580                 585                 590         


Ala Glu Glu Val Ser Ala Leu Phe Ala Gly Glu Leu Asn Pro Val Ala 
        595                 600                 605             


Pro Lys Ala Gln Lys Lys Val Pro Val Pro Glu Gly Leu Asp Leu Asp 
    610                 615                 620                 


Ala Trp Ile Asn Glu Pro Leu Ser Asp Ser Glu Ser Glu Asp Glu Arg 
625                 630                 635                 640 


Pro Arg Ala Val Phe His Glu Glu Glu Gln Arg Arg Pro Lys His Arg 
                645                 650                 655     


Pro Ser Glu Ala Asp Glu Glu Glu Leu Ala Arg Arg Arg Glu Ala Arg 
            660                 665                 670         


Lys Gln Glu Gln Ala Asn Asn Pro Phe Tyr Ile Lys Ser Ser Pro Ser 
        675                 680                 685             


Pro Gln Lys Arg Tyr Gln Asp Thr Pro Gly Val Glu His Ile Pro Val 
    690                 695                 700                 


Val Gln Ile Asp Leu Ser Val Pro Leu Lys Val Pro Gly Leu Pro Met 
705                 710                 715                 720 


Ser Asp Gln Tyr Val Lys Leu Glu Glu Glu Arg Arg His Arg Gln Lys 
                725                 730                 735     


Leu Glu Lys Asp Lys Arg Arg Lys Lys Arg Lys Glu Lys Glu Lys Lys 
            740                 745                 750         


Gly Lys Arg Arg His Ser Ser Leu Pro Thr Glu Ser Asp Glu Asp Ile 
        755                 760                 765             


Ala Pro Ala Gln Gln Val Asp Ile Val Thr Glu Glu Met Pro Glu Asn 
    770                 775                 780                 


Ala Leu Pro Ser Asp Glu Asp Asp Lys Asp Pro Asn Asp Pro Tyr Arg 
785                 790                 795                 800 


Ala Leu Asp Ile Asp Leu Asp Lys Pro Leu Ala Asp Ser Glu Lys Leu 
                805                 810                 815     


Pro Ile Gln Lys His Arg Asn Thr Glu Thr Ser Lys Ser Pro Glu Lys 
            820                 825                 830         


Asp Val Pro Met Val Glu Lys Lys Ser Lys Lys Pro Lys Lys Lys Glu 
        835                 840                 845             


Lys Lys His Lys Glu Lys Glu Arg Asp Lys Glu Lys Lys Lys Glu Lys 
    850                 855                 860                 


Glu Lys Lys Ala Glu Asp Leu Asp Phe Trp Leu Ser Thr Thr Pro Pro 
865                 870                 875                 880 


Pro Ala Pro Ala Pro Ala Pro Ala Pro Val Pro Ser Thr Gly Glu Leu 
                885                 890                 895     


Ser Val Asn Thr Val Thr Thr Pro Lys Asp Glu Cys Glu Asp Ala Lys 
            900                 905                 910         


Thr Glu Ala Gln Gly Glu Glu Asp Asp Ala Glu Gly Gln Asp Gln Asp 
        915                 920                 925             


Lys Lys Ser Pro Lys Pro Lys Lys Lys Lys His Arg Lys Glu Lys Glu 
    930                 935                 940                 


Glu Arg Thr Lys Gly Lys Lys Lys Ser Lys Lys Gln Pro Pro Gly Ser 
945                 950                 955                 960 


Glu Glu Ala Ala Gly Glu Pro Val Gln Asn Gly Ala Pro Glu Glu Glu 
                965                 970                 975     


Gln Leu Pro Pro Glu Ser Ser Tyr Ser Leu Leu Ala Glu Asn Ser Tyr 
            980                 985                 990         


Val Lys Met Thr Cys Asp Ile Arg  Gly Ser Leu Gln Glu  Asp Ser Gln 
        995                 1000                 1005             


Val Thr  Val Ala Ile Val Leu  Glu Asn Arg Ser Ser  Ser Ile Leu 
    1010                 1015                 1020             


Lys Gly  Met Glu Leu Ser Val  Leu Asp Ser Leu Asn  Ala Arg Met 
    1025                 1030                 1035             


Ala Arg  Pro Gln Gly Ser Ser  Val His Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Phe Gln  Leu Pro Pro Gly Val  Ser Asn Glu Ala Gln  Tyr Val Phe 
    1055                 1060                 1065             


Thr Ile  Gln Ser Ile Val Met  Ala Gln Lys Leu Lys  Gly Thr Leu 
    1070                 1075                 1080             


Ser Phe  Ile Ala Lys Asn Asp  Glu Gly Ala Thr His  Glu Lys Leu 
    1085                 1090                 1095             


Asp Phe  Arg Leu His Phe Ser  Cys Ser Ser Tyr Leu  Ile Thr Thr 
    1100                 1105                 1110             


Pro Cys  Tyr Ser Asp Ala Phe  Ala Lys Leu Leu Glu  Ser Gly Asp 
    1115                 1120                 1125             


Leu Ser  Met Ser Ser Ile Lys  Val Asp Gly Ile Arg  Met Ser Phe 
    1130                 1135                 1140             


Gln Asn  Leu Leu Ala Lys Ile  Cys Phe His His His  Phe Ser Val 
    1145                 1150                 1155             


Val Glu  Arg Val Asp Ser Cys  Ala Ser Met Tyr Ser  Arg Ser Ile 
    1160                 1165                 1170             


Gln Gly  His His Val Cys Leu  Leu Val Lys Lys Gly  Glu Asn Ser 
    1175                 1180                 1185             


Val Ser  Val Asp Gly Lys Cys  Ser Asp Ser Thr Leu  Leu Ser Asn 
    1190                 1195                 1200             


Leu Leu  Glu Glu Met Lys Ala  Thr Leu Ala Lys Cys  
    1205                 1210                 1215 


<210>  606
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP3M2__Homo_sapiens__NP_006794

<400>  606

Met Ile His Ser Leu Phe Leu Ile Asn Ser Ser Gly Asp Ile Phe Leu 
1               5                   10                  15      


Glu Lys His Trp Lys Ser Val Val Ser Arg Ser Val Cys Asp Tyr Phe 
            20                  25                  30          


Phe Glu Ala Gln Glu Arg Ala Thr Glu Ala Glu Asn Val Pro Pro Val 
        35                  40                  45              


Ile Pro Thr Pro His His Tyr Leu Leu Ser Val Tyr Arg His Lys Ile 
    50                  55                  60                  


Phe Phe Val Ala Val Ile Gln Thr Glu Val Pro Pro Leu Phe Val Ile 
65                  70                  75                  80  


Glu Phe Leu His Arg Val Val Asp Thr Phe Gln Asp Tyr Phe Gly Val 
                85                  90                  95      


Cys Ser Glu Pro Val Ile Lys Asp Asn Val Val Val Val Tyr Glu Val 
            100                 105                 110         


Leu Glu Glu Met Leu Asp Asn Gly Phe Pro Leu Ala Thr Glu Ser Asn 
        115                 120                 125             


Ile Leu Lys Glu Leu Ile Lys Pro Pro Thr Ile Leu Arg Thr Val Val 
    130                 135                 140                 


Asn Thr Ile Thr Gly Ser Thr Asn Val Gly Asp Gln Leu Pro Thr Gly 
145                 150                 155                 160 


Gln Leu Ser Val Val Pro Trp Arg Arg Thr Gly Val Lys Tyr Thr Asn 
                165                 170                 175     


Asn Glu Ala Tyr Phe Asp Val Ile Glu Glu Ile Asp Ala Ile Ile Asp 
            180                 185                 190         


Lys Ser Gly Ser Thr Ile Thr Ala Glu Ile Gln Gly Val Ile Asp Ala 
        195                 200                 205             


Cys Val Lys Leu Thr Gly Met Pro Asp Leu Thr Leu Ser Phe Met Asn 
    210                 215                 220                 


Pro Arg Leu Leu Asp Asp Val Ser Phe His Pro Cys Val Arg Phe Lys 
225                 230                 235                 240 


Arg Trp Glu Ser Glu Arg Ile Leu Ser Phe Ile Pro Pro Asp Gly Asn 
                245                 250                 255     


Phe Arg Leu Leu Ser Tyr His Val Ser Ala Gln Asn Leu Val Ala Ile 
            260                 265                 270         


Pro Val Tyr Val Lys His Asn Ile Ser Phe Arg Asp Ser Ser Ser Leu 
        275                 280                 285             


Gly Arg Phe Glu Ile Thr Val Gly Pro Lys Gln Thr Met Gly Lys Thr 
    290                 295                 300                 


Ile Glu Gly Val Thr Val Thr Ser Gln Met Pro Lys Gly Val Leu Asn 
305                 310                 315                 320 


Met Ser Leu Thr Pro Ser Gln Gly Thr His Thr Phe Asp Pro Val Thr 
                325                 330                 335     


Lys Met Leu Ser Trp Asp Val Gly Lys Ile Asn Pro Gln Lys Leu Pro 
            340                 345                 350         


Ser Leu Lys Gly Thr Met Ser Leu Gln Ala Gly Ala Ser Lys Pro Asp 
        355                 360                 365             


Glu Asn Pro Thr Ile Asn Leu Gln Phe Lys Ile Gln Gln Leu Ala Ile 
    370                 375                 380                 


Ser Gly Leu Lys Val Asn Arg Leu Asp Met Tyr Gly Glu Lys Tyr Lys 
385                 390                 395                 400 


Pro Phe Lys Gly Ile Lys Tyr Met Thr Lys Ala Gly Lys Phe Gln Val 
                405                 410                 415     


Arg Thr 
        


<210>  607
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP3S1__Homo_sapiens__NP_001275

<400>  607

Met Ile Lys Ala Ile Leu Ile Phe Asn Asn His Gly Lys Pro Arg Leu 
1               5                   10                  15      


Ser Lys Phe Tyr Gln Pro Tyr Ser Glu Asp Thr Gln Gln Gln Ile Ile 
            20                  25                  30          


Arg Glu Thr Phe His Leu Val Ser Lys Arg Asp Glu Asn Val Cys Asn 
        35                  40                  45              


Phe Leu Glu Gly Gly Leu Leu Ile Gly Gly Ser Asp Asn Lys Leu Ile 
    50                  55                  60                  


Tyr Arg His Tyr Ala Thr Leu Tyr Phe Val Phe Cys Val Asp Ser Ser 
65                  70                  75                  80  


Glu Ser Glu Leu Gly Ile Leu Asp Leu Ile Gln Val Phe Val Glu Thr 
                85                  90                  95      


Leu Asp Lys Cys Phe Glu Asn Val Cys Glu Leu Asp Leu Ile Phe His 
            100                 105                 110         


Val Asp Lys Val His Asn Ile Leu Ala Glu Met Val Met Gly Gly Met 
        115                 120                 125             


Val Leu Glu Thr Asn Met Asn Glu Ile Val Thr Gln Ile Asp Ala Gln 
    130                 135                 140                 


Asn Lys Leu Glu Lys Ser Glu Ala Gly Leu Ala Gly Ala Pro Ala Arg 
145                 150                 155                 160 


Ala Val Ser Ala Val Lys Asn Met Asn Leu Pro Glu Ile Pro Arg Asn 
                165                 170                 175     


Ile Asn Ile Gly Asp Ile Ser Ile Lys Val Pro Asn Leu Pro Ser Phe 
            180                 185                 190         


Lys 
    


<210>  608
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP3S2__Homo_sapiens__NP_005820

<400>  608

Met Ile Gln Ala Ile Leu Val Phe Asn Asn His Gly Lys Pro Arg Leu 
1               5                   10                  15      


Val Arg Phe Tyr Gln Arg Phe Pro Glu Glu Ile Gln Gln Gln Ile Val 
            20                  25                  30          


Arg Glu Thr Phe His Leu Val Leu Lys Arg Asp Asp Asn Ile Cys Asn 
        35                  40                  45              


Phe Leu Glu Gly Gly Ser Leu Ile Gly Gly Ser Asp Tyr Lys Leu Ile 
    50                  55                  60                  


Tyr Arg His Tyr Ala Thr Leu Tyr Phe Val Phe Cys Val Asp Ser Ser 
65                  70                  75                  80  


Glu Ser Glu Leu Gly Ile Leu Asp Leu Ile Gln Val Phe Val Glu Thr 
                85                  90                  95      


Leu Asp Lys Cys Phe Glu Asn Val Cys Glu Leu Asp Leu Ile Phe His 
            100                 105                 110         


Met Asp Lys Val His Tyr Ile Leu Gln Glu Val Val Met Gly Gly Met 
        115                 120                 125             


Val Leu Glu Thr Asn Met Asn Glu Ile Val Ala Gln Ile Glu Ala Gln 
    130                 135                 140                 


Asn Arg Leu Glu Lys Ser Glu Gly Gly Leu Ser Ala Ala Pro Ala Arg 
145                 150                 155                 160 


Ala Val Ser Ala Val Lys Asn Ile Asn Leu Pro Glu Ile Pro Arg Asn 
                165                 170                 175     


Ile Asn Ile Gly Asp Leu Asn Ile Lys Val Pro Asn Leu Ser Gln Phe 
            180                 185                 190         


Val 
    


<210>  609
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP4B1__Homo_sapiens__XP_011538826

<400>  609

Met Pro Tyr Leu Gly Ser Glu Asp Val Val Lys Glu Leu Lys Lys Ala 
1               5                   10                  15      


Leu Cys Asn Pro His Ile Gln Ala Asp Arg Leu Arg Tyr Arg Asn Val 
            20                  25                  30          


Ile Gln Arg Val Ile Arg Met Pro Gly Val Gln Glu Tyr Ile Gln Gln 
        35                  40                  45              


Pro Ile Leu Asn Gly Leu Arg Asp Lys Ala Ser Tyr Val Arg Arg Val 
    50                  55                  60                  


Ala Val Leu Gly Cys Ala Lys Met His Asn Leu His Gly Asp Ser Glu 
65                  70                  75                  80  


Val Asp Gly Ala Leu Val Asn Glu Leu Tyr Ser Leu Leu Arg Asp Gln 
                85                  90                  95      


Asp Pro Ile Val Val Val Asn Cys Leu Arg Ser Leu Glu Glu Ile Leu 
            100                 105                 110         


Lys Gln Glu Gly Gly Val Val Ile Asn Lys Pro Ile Ala His His Leu 
        115                 120                 125             


Leu Asn Arg Met Ser Lys Leu Asp Gln Trp Gly Gln Ala Glu Val Leu 
    130                 135                 140                 


Asn Phe Leu Leu Arg Tyr Gln Pro Arg Ser Glu Glu Glu Leu Phe Asp 
145                 150                 155                 160 


Ile Leu Asn Leu Leu Asp Ser Phe Leu Lys Ser Ser Ser Pro Gly Val 
                165                 170                 175     


Val Met Gly Ala Thr Lys Leu Phe Leu Ile Leu Ala Lys Met Phe Pro 
            180                 185                 190         


His Val Gln Thr Asp Val Leu Val Arg Val Lys Gly Pro Leu Leu Ala 
        195                 200                 205             


Ala Cys Ser Ser Glu Ser Arg Glu Leu Cys Phe Val Ala Leu Cys His 
    210                 215                 220                 


Val Arg Gln Ile Leu His Ser Leu Pro Gly His Phe Ser Ser His Tyr 
225                 230                 235                 240 


Lys Lys Phe Phe Cys Ser Tyr Ser Glu Pro His Tyr Ile Lys Leu Gln 
                245                 250                 255     


Lys Val Glu Val Leu Cys Glu Leu Val Asn Asp Glu Asn Val Gln Gln 
            260                 265                 270         


Val Leu Glu Glu Leu Arg Gly Tyr Cys Thr Asp Val Ser Ala Asp Phe 
        275                 280                 285             


Ala Gln Ala Ala Ile Phe Ala Ile Gly Gly Ile Ala Arg Thr Tyr Thr 
    290                 295                 300                 


Asp Gln Cys Val Gln Ile Leu Thr Glu Leu Leu Gly Leu Arg Gln Glu 
305                 310                 315                 320 


His Ile Thr Thr Val Val Val Gln Thr Phe Arg Asp Leu Val Trp Leu 
                325                 330                 335     


Cys Pro Gln Cys Thr Glu Ala Val Cys Gln Ala Leu Pro Gly Cys Glu 
            340                 345                 350         


Glu Asn Ile Gln Asp Ser Glu Gly Lys Gln Ala Leu Ile Trp Leu Leu 
        355                 360                 365             


Gly Val His Gly Glu Arg Ile Pro Asn Ala Pro Tyr Val Leu Glu Asp 
    370                 375                 380                 


Phe Val Glu Asn Val Lys Ser Glu Thr Phe Pro Ala Val Lys Met Glu 
385                 390                 395                 400 


Leu Leu Thr Ala Leu Leu Arg Leu Phe Leu Ser Arg Pro Ala Glu Cys 
                405                 410                 415     


Gln Asp Met Leu Gly Arg Leu Leu Tyr Tyr Cys Ile Glu Glu Glu Lys 
            420                 425                 430         


Asp Met Ala Val Arg Asp Arg Gly Leu Phe Tyr Tyr Arg Leu Leu Leu 
        435                 440                 445             


Val Gly Ile Asp Glu Val Lys Arg Ile Leu Cys Ser Pro Lys Ser Asp 
    450                 455                 460                 


Pro Thr Leu Gly Leu Leu Glu Asp Pro Ala Glu Arg Pro Val Asn Ser 
465                 470                 475                 480 


Trp Ala Ser Asp Phe Asn Thr Leu Val Pro Val Tyr Gly Lys Ala His 
                485                 490                 495     


Trp Ala Thr Ile Ser Lys Cys Gln Gly Ala Glu Arg Cys Asp Pro Glu 
            500                 505                 510         


Leu Pro Lys Thr Ser Ser Phe Ala Ala Ser Gly Pro Leu Ile Pro Glu 
        515                 520                 525             


Glu Asn Lys Glu Arg Val Gln Glu Leu Pro Asp Ser Gly Ala Leu Met 
    530                 535                 540                 


Leu Val Pro Asn Arg Gln Leu Thr Ala Asp Tyr Phe Glu Lys Thr Trp 
545                 550                 555                 560 


Leu Ser Leu Lys Val Ala His Gln Gln Val Leu Pro Trp Arg Gly Glu 
                565                 570                 575     


Phe His Pro Asp Thr Leu Gln Met Ala Leu Gln Val Val Asn Ile Gln 
            580                 585                 590         


Thr Ile Ala Met Ser Arg Ala Gly Ser Arg Pro Trp Lys Ala Tyr Leu 
        595                 600                 605             


Ser Ala Gln Asp Asp Thr Gly Cys Leu Phe Leu Thr Glu Leu Leu Leu 
    610                 615                 620                 


Glu Pro Gly Asn Ser Glu Met Gln Ile Ser Val Lys Gln Asn Glu Ala 
625                 630                 635                 640 


Arg Thr Glu Thr Leu Asn Ser Phe Ile Ser Val Leu Glu Thr Val Ile 
                645                 650                 655     


Gly Thr Ile Glu Glu Ile Lys Ser 
            660                 


<210>  610
<211>  1137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP4E1__Homo_sapiens__NP_031373

<400>  610

Met Ser Asp Ile Val Glu Lys Thr Leu Thr Ala Leu Pro Gly Leu Phe 
1               5                   10                  15      


Leu Gln Asn Gln Pro Gly Gly Gly Pro Ala Ala Ala Lys Ala Ser Phe 
            20                  25                  30          


Ser Ser Arg Leu Gly Ser Leu Val Arg Gly Ile Thr Ala Leu Thr Ser 
        35                  40                  45              


Lys His Glu Glu Glu Lys Leu Ile Gln Gln Glu Leu Ser Ser Leu Lys 
    50                  55                  60                  


Ala Thr Val Ser Ala Pro Thr Thr Thr Leu Lys Met Met Lys Glu Cys 
65                  70                  75                  80  


Met Val Arg Leu Ile Tyr Cys Glu Met Leu Gly Tyr Asp Ala Ser Phe 
                85                  90                  95      


Gly Tyr Ile His Ala Ile Lys Leu Ala Gln Gln Gly Asn Leu Leu Glu 
            100                 105                 110         


Lys Arg Val Gly Tyr Leu Ala Val Ser Leu Phe Leu His Glu Ser His 
        115                 120                 125             


Glu Leu Leu Leu Leu Leu Val Asn Thr Val Val Lys Asp Leu Gln Ser 
    130                 135                 140                 


Thr Asn Leu Val Glu Val Cys Met Ala Leu Thr Val Val Ser Gln Ile 
145                 150                 155                 160 


Phe Pro Cys Glu Met Ile Pro Ala Val Leu Pro Leu Ile Glu Asp Lys 
                165                 170                 175     


Leu Gln His Ser Lys Glu Ile Val Arg Arg Lys Ala Val Leu Ala Leu 
            180                 185                 190         


Tyr Lys Phe His Leu Ile Ala Pro Asn Gln Val Gln His Ile His Ile 
        195                 200                 205             


Lys Phe Arg Lys Ala Leu Cys Asp Arg Asp Val Gly Val Met Ala Ala 
    210                 215                 220                 


Ser Leu His Ile Tyr Leu Arg Met Ile Lys Glu Asn Ser Ser Gly Tyr 
225                 230                 235                 240 


Lys Asp Leu Thr Gly Ser Phe Val Thr Ile Leu Lys Gln Val Val Gly 
                245                 250                 255     


Gly Lys Leu Pro Val Glu Phe Asn Tyr His Ser Val Pro Ala Pro Trp 
            260                 265                 270         


Leu Gln Ile Gln Leu Leu Arg Ile Leu Gly Leu Leu Gly Lys Asp Asp 
        275                 280                 285             


Gln Arg Thr Ser Glu Leu Met Tyr Asp Val Leu Asp Glu Ser Leu Arg 
    290                 295                 300                 


Arg Ala Glu Leu Asn His Asn Val Thr Tyr Ala Ile Leu Phe Glu Cys 
305                 310                 315                 320 


Val His Thr Val Tyr Ser Ile Tyr Pro Lys Ser Glu Leu Leu Glu Lys 
                325                 330                 335     


Ala Ala Lys Cys Ile Gly Lys Phe Val Leu Ser Pro Lys Ile Asn Leu 
            340                 345                 350         


Lys Tyr Leu Gly Leu Lys Ala Leu Thr Tyr Val Ile Gln Gln Asp Pro 
        355                 360                 365             


Thr Leu Ala Leu Gln His Gln Met Thr Ile Ile Glu Cys Leu Asp His 
    370                 375                 380                 


Pro Asp Pro Ile Ile Lys Arg Glu Thr Leu Glu Leu Leu Tyr Arg Ile 
385                 390                 395                 400 


Thr Asn Ala Gln Asn Ile Thr Val Ile Val Gln Lys Met Leu Glu Tyr 
                405                 410                 415     


Leu His Gln Ser Lys Glu Glu Tyr Val Ile Val Asn Leu Val Gly Lys 
            420                 425                 430         


Ile Ala Glu Leu Ala Glu Lys Tyr Ala Pro Asp Asn Ala Trp Phe Ile 
        435                 440                 445             


Gln Thr Met Asn Ala Val Phe Ser Val Gly Gly Asp Val Met His Pro 
    450                 455                 460                 


Asp Ile Pro Asn Asn Phe Leu Arg Leu Leu Ala Glu Gly Phe Asp Asp 
465                 470                 475                 480 


Glu Thr Glu Asp Gln Gln Leu Arg Leu Tyr Ala Val Gln Ser Tyr Leu 
                485                 490                 495     


Thr Leu Leu Asp Met Glu Asn Val Phe Tyr Pro Gln Arg Phe Leu Gln 
            500                 505                 510         


Val Met Ser Trp Val Leu Gly Glu Tyr Ser Tyr Leu Leu Asp Lys Glu 
        515                 520                 525             


Thr Pro Glu Glu Val Ile Ala Lys Leu Tyr Lys Leu Leu Met Asn Asp 
    530                 535                 540                 


Ser Val Ser Ser Glu Thr Lys Ala Trp Leu Ile Ala Ala Val Thr Lys 
545                 550                 555                 560 


Leu Thr Ser Gln Ala His Ser Ser Asn Thr Val Glu Arg Leu Ile His 
                565                 570                 575     


Glu Phe Thr Ile Ser Leu Asp Thr Cys Met Arg Gln His Ala Phe Glu 
            580                 585                 590         


Leu Lys His Leu His Glu Asn Val Glu Leu Met Lys Ser Leu Leu Pro 
        595                 600                 605             


Val Asp Arg Ser Cys Glu Asp Leu Val Val Asp Ala Ser Leu Ser Phe 
    610                 615                 620                 


Leu Asp Gly Phe Val Ala Glu Gly Leu Ser Gln Gly Ala Ala Pro Tyr 
625                 630                 635                 640 


Lys Pro Pro His Gln Arg Gln Glu Glu Lys Leu Ser Gln Glu Lys Val 
                645                 650                 655     


Leu Asn Phe Glu Pro Tyr Gly Leu Ser Phe Ser Ser Ser Gly Phe Thr 
            660                 665                 670         


Gly Arg Gln Ser Pro Ala Gly Ile Ser Leu Gly Ser Asp Val Ser Gly 
        675                 680                 685             


Asn Ser Ala Glu Thr Gly Leu Lys Glu Thr Asn Ser Leu Lys Leu Glu 
    690                 695                 700                 


Gly Ile Lys Lys Leu Trp Gly Lys Glu Gly Tyr Leu Pro Lys Lys Glu 
705                 710                 715                 720 


Ser Lys Thr Gly Asp Glu Ser Gly Ala Leu Pro Val Pro Gln Glu Ser 
                725                 730                 735     


Ile Met Glu Asn Val Asp Gln Ala Ile Thr Lys Lys Asp Gln Ser Gln 
            740                 745                 750         


Val Leu Thr Gln Ser Lys Glu Glu Lys Glu Lys Gln Leu Leu Ala Ser 
        755                 760                 765             


Ser Leu Phe Val Gly Leu Gly Ser Glu Ser Thr Ile Asn Leu Leu Gly 
    770                 775                 780                 


Lys Ala Asp Thr Val Ser His Lys Phe Arg Arg Lys Ser Lys Val Lys 
785                 790                 795                 800 


Glu Ala Lys Ser Gly Glu Thr Thr Ser Thr His Asn Met Thr Cys Ser 
                805                 810                 815     


Ser Phe Ser Ser Leu Ser Asn Val Ala Tyr Glu Asp Asp Tyr Tyr Ser 
            820                 825                 830         


Asn Thr Leu His Asp Thr Gly Asp Lys Glu Leu Lys Lys Phe Ser Leu 
        835                 840                 845             


Thr Ser Glu Leu Leu Asp Ser Glu Ser Leu Thr Glu Leu Pro Leu Val 
    850                 855                 860                 


Glu Lys Phe Ser Tyr Cys Ser Leu Ser Thr Pro Ser Leu Phe Ala Asn 
865                 870                 875                 880 


Asn Asn Met Glu Ile Phe His Pro Pro Gln Ser Thr Ala Ala Ser Val 
                885                 890                 895     


Ala Lys Glu Ser Ser Leu Ala Ser Ser Phe Leu Glu Glu Thr Thr Glu 
            900                 905                 910         


Tyr Ile His Ser Asn Ala Met Glu Val Cys Asn Asn Glu Thr Ile Ser 
        915                 920                 925             


Val Ser Ser Tyr Lys Ile Trp Lys Asp Asp Cys Leu Leu Met Val Trp 
    930                 935                 940                 


Ser Val Thr Asn Lys Ser Gly Leu Glu Leu Lys Ser Ala Asp Leu Glu 
945                 950                 955                 960 


Ile Phe Pro Ala Glu Asn Phe Lys Val Thr Glu Gln Pro Gly Cys Cys 
                965                 970                 975     


Leu Pro Val Met Glu Ala Glu Ser Thr Lys Ser Phe Gln Tyr Ser Val 
            980                 985                 990         


Gln Ile Glu Lys Pro Phe Thr Glu  Gly Asn Leu Thr Gly  Phe Ile Ser 
        995                 1000                 1005             


Tyr His  Met Met Asp Thr His  Ser Ala Gln Leu Glu  Phe Ser Val 
    1010                 1015                 1020             


Asn Leu  Ser Leu Leu Asp Phe  Ile Arg Pro Leu Lys  Ile Ser Ser 
    1025                 1030                 1035             


Asp Asp  Phe Gly Lys Leu Trp  Leu Ser Phe Ala Asn  Asp Val Lys 
    1040                 1045                 1050             


Gln Asn  Val Lys Met Ser Glu  Ser Gln Ala Ala Leu  Pro Ser Ala 
    1055                 1060                 1065             


Leu Lys  Thr Leu Gln Gln Lys  Leu Arg Leu His Ile  Ile Glu Ile 
    1070                 1075                 1080             


Ile Gly  Asn Glu Gly Leu Leu  Ala Cys Gln Leu Leu  Pro Ser Ile 
    1085                 1090                 1095             


Pro Cys  Leu Leu His Cys Arg  Val His Ala Asp Val  Leu Ala Leu 
    1100                 1105                 1110             


Trp Phe  Arg Ser Ser Cys Ser  Thr Leu Pro Asp Tyr  Leu Leu Tyr 
    1115                 1120                 1125             


Gln Cys  Gln Lys Val Met Glu  Gly Ser 
    1130                 1135         


<210>  611
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP4M1__Homo_sapiens__NP_004713

<400>  611

Met Ile Ser Gln Phe Phe Ile Leu Ser Ser Lys Gly Asp Pro Leu Ile 
1               5                   10                  15      


Tyr Lys Asp Phe Arg Gly Asp Ser Gly Gly Arg Asp Val Ala Glu Leu 
            20                  25                  30          


Phe Tyr Arg Lys Leu Thr Gly Leu Pro Gly Asp Glu Ser Pro Val Val 
        35                  40                  45              


Met His His His Gly Arg His Phe Ile His Ile Arg His Ser Gly Leu 
    50                  55                  60                  


Tyr Leu Val Val Thr Thr Ser Glu Asn Val Ser Pro Phe Ser Leu Leu 
65                  70                  75                  80  


Glu Leu Leu Ser Arg Leu Ala Thr Leu Leu Gly Asp Tyr Cys Gly Ser 
                85                  90                  95      


Leu Gly Glu Gly Thr Ile Ser Arg Asn Val Ala Leu Val Tyr Glu Leu 
            100                 105                 110         


Leu Asp Glu Val Leu Asp Tyr Gly Tyr Val Gln Thr Thr Ser Thr Glu 
        115                 120                 125             


Met Leu Arg Asn Phe Ile Gln Thr Glu Ala Val Val Ser Lys Pro Phe 
    130                 135                 140                 


Ser Leu Phe Asp Leu Ser Ser Val Gly Leu Phe Gly Ala Glu Thr Gln 
145                 150                 155                 160 


Gln Ser Lys Val Ala Pro Ser Ser Ala Ala Ser Arg Pro Val Leu Ser 
                165                 170                 175     


Ser Arg Ser Asp Gln Ser Gln Lys Asn Glu Val Phe Leu Asp Val Val 
            180                 185                 190         


Glu Arg Leu Ser Val Leu Ile Ala Ser Asn Gly Ser Leu Leu Lys Val 
        195                 200                 205             


Asp Val Gln Gly Glu Ile Arg Leu Lys Ser Phe Leu Pro Ser Gly Ser 
    210                 215                 220                 


Glu Met Arg Ile Gly Leu Thr Glu Glu Phe Cys Val Gly Lys Ser Glu 
225                 230                 235                 240 


Leu Arg Gly Tyr Gly Pro Gly Ile Arg Val Asp Glu Val Ser Phe His 
                245                 250                 255     


Ser Ser Val Asn Leu Asp Glu Phe Glu Ser His Arg Ile Leu Arg Leu 
            260                 265                 270         


Gln Pro Pro Gln Gly Glu Leu Thr Val Met Arg Tyr Gln Leu Ser Asp 
        275                 280                 285             


Asp Leu Pro Ser Pro Leu Pro Phe Arg Leu Phe Pro Ser Val Gln Trp 
    290                 295                 300                 


Asp Arg Gly Ser Gly Arg Leu Gln Val Tyr Leu Lys Leu Arg Cys Asp 
305                 310                 315                 320 


Leu Leu Ser Lys Ser Gln Ala Leu Asn Val Arg Leu His Leu Pro Leu 
                325                 330                 335     


Pro Arg Gly Val Val Ser Leu Ser Gln Glu Leu Ser Ser Pro Glu Gln 
            340                 345                 350         


Lys Ala Glu Leu Ala Glu Gly Ala Leu Arg Trp Asp Leu Pro Arg Val 
        355                 360                 365             


Gln Gly Gly Ser Gln Leu Ser Gly Leu Phe Gln Met Asp Val Pro Gly 
    370                 375                 380                 


Pro Pro Gly Pro Pro Ser His Gly Leu Ser Thr Ser Ala Ser Pro Leu 
385                 390                 395                 400 


Gly Leu Gly Pro Ala Ser Leu Ser Phe Glu Leu Pro Arg His Thr Cys 
                405                 410                 415     


Ser Gly Leu Gln Val Arg Phe Leu Arg Leu Ala Phe Arg Pro Cys Gly 
            420                 425                 430         


Asn Ala Asn Pro His Lys Trp Val Arg His Leu Ser His Ser Asp Ala 
        435                 440                 445             


Tyr Val Ile Arg Ile 
    450             


<210>  612
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP4S1__Homo_sapiens__NP_001121598

<400>  612

Met Ile Lys Phe Phe Leu Met Val Asn Lys Gln Gly Gln Thr Arg Leu 
1               5                   10                  15      


Ser Lys Tyr Tyr Glu His Val Asp Ile Asn Lys Arg Thr Leu Leu Glu 
            20                  25                  30          


Thr Glu Val Ile Lys Ser Cys Leu Ser Arg Ser Asn Glu Gln Cys Ser 
        35                  40                  45              


Phe Ile Glu Tyr Lys Asp Phe Lys Leu Ile Tyr Arg Gln Tyr Ala Ala 
    50                  55                  60                  


Leu Phe Ile Val Val Gly Val Asn Asp Thr Glu Asn Glu Met Ala Ile 
65                  70                  75                  80  


Tyr Glu Phe Ile His Asn Phe Val Glu Val Leu Asp Glu Tyr Phe Ser 
                85                  90                  95      


Arg Val Ser Glu Leu Asp Ile Met Phe Asn Leu Asp Lys Val His Ile 
            100                 105                 110         


Ile Leu Asp Glu Met Val Leu Asn Gly Cys Ile Val Glu Thr Asn Arg 
        115                 120                 125             


Ala Arg Ile Leu Ala Pro Leu Leu Ile Leu Asp Lys Met Ser Glu Ser 
    130                 135                 140                 


<210>  613
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP5M1__Homo_sapiens__NP_060699

<400>  613

Met Ala Gln Arg Ala Val Trp Leu Ile Ser His Glu Pro Gly Thr Pro 
1               5                   10                  15      


Leu Cys Gly Thr Val Arg Phe Ser Arg Arg Tyr Pro Thr Val Glu Lys 
            20                  25                  30          


Arg Ala Arg Val Phe Asn Gly Ala Ser Tyr Val Pro Val Pro Glu Asp 
        35                  40                  45              


Gly Pro Phe Leu Lys Ala Leu Leu Phe Glu Leu Arg Leu Leu Asp Asp 
    50                  55                  60                  


Asp Lys Asp Phe Val Glu Ser Arg Asp Ser Cys Ser Arg Ile Asn Lys 
65                  70                  75                  80  


Thr Ser Ile Tyr Gly Leu Leu Ile Gly Gly Glu Glu Leu Trp Pro Val 
                85                  90                  95      


Val Ala Phe Leu Lys Asn Asp Met Ile Tyr Ala Cys Val Pro Leu Val 
            100                 105                 110         


Glu Gln Thr Leu Ser Pro Arg Pro Pro Leu Ile Ser Val Ser Gly Val 
        115                 120                 125             


Ser Gln Gly Phe Glu Phe Leu Phe Gly Ile Gln Asp Phe Leu Tyr Ser 
    130                 135                 140                 


Gly Gln Lys Asn Asp Ser Glu Leu Asn Thr Lys Leu Ser Gln Leu Pro 
145                 150                 155                 160 


Asp Leu Leu Leu Gln Ala Cys Pro Phe Gly Thr Leu Leu Asp Ala Asn 
                165                 170                 175     


Leu Gln Asn Ser Leu Asp Asn Thr Asn Phe Ala Ser Val Thr Gln Pro 
            180                 185                 190         


Gln Lys Gln Pro Ala Trp Lys Thr Gly Thr Tyr Lys Gly Lys Pro Gln 
        195                 200                 205             


Val Ser Ile Ser Ile Thr Glu Lys Val Lys Ser Met Gln Tyr Asp Lys 
    210                 215                 220                 


Gln Gly Ile Ala Asp Thr Trp Gln Val Val Gly Thr Val Thr Cys Lys 
225                 230                 235                 240 


Cys Asp Leu Glu Gly Ile Met Pro Asn Val Thr Ile Ser Leu Ser Leu 
                245                 250                 255     


Pro Thr Asn Gly Ser Pro Leu Gln Asp Ile Leu Val His Pro Cys Val 
            260                 265                 270         


Thr Ser Leu Asp Ser Ala Ile Leu Thr Ser Ser Ser Ile Asp Ala Met 
        275                 280                 285             


Asp Asp Ser Ala Phe Ser Gly Pro Tyr Lys Phe Pro Phe Thr Pro Pro 
    290                 295                 300                 


Leu Glu Ser Phe Asn Leu Cys Phe Tyr Thr Ser Gln Val Pro Val Pro 
305                 310                 315                 320 


Pro Ile Leu Gly Phe Tyr Gln Met Lys Glu Glu Glu Val Gln Leu Arg 
                325                 330                 335     


Ile Thr Ile Asn Leu Lys Leu His Glu Ser Val Lys Asn Asn Phe Glu 
            340                 345                 350         


Phe Cys Glu Ala His Ile Pro Phe Tyr Asn Arg Gly Pro Ile Thr His 
        355                 360                 365             


Leu Glu Tyr Lys Thr Ser Phe Gly Gln Leu Glu Val Phe Arg Glu Lys 
    370                 375                 380                 


Ser Leu Leu Ile Trp Ile Ile Gly Gln Lys Phe Pro Lys Ser Met Glu 
385                 390                 395                 400 


Ile Ser Leu Ser Gly Thr Val Thr Phe Gly Ala Lys Ser His Glu Lys 
                405                 410                 415     


Gln Pro Phe Asp Pro Ile Cys Thr Gly Glu Thr Ala Tyr Leu Lys Leu 
            420                 425                 430         


His Phe Arg Ile Leu Asp Tyr Thr Leu Thr Gly Cys Tyr Ala Asp Gln 
        435                 440                 445             


His Ser Val Gln Val Phe Ala Ser Gly Lys Pro Lys Ile Ser Ala His 
    450                 455                 460                 


Arg Lys Leu Ile Ser Ser Asp Tyr Tyr Ile Trp Asn Ser Lys Ala Pro 
465                 470                 475                 480 


Ala Pro Val Thr Tyr Gly Ser Leu Leu Leu 
                485                 490 


<210>  614
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AP5Z1__Homo_sapiens__NP_055670

<400>  614

Met Phe Ser Ala Gly Ala Glu Ser Leu Leu His Gln Ala Arg Glu Ile 
1               5                   10                  15      


Gln Asp Glu Glu Leu Lys Lys Phe Cys Ser Arg Ile Cys Lys Leu Leu 
            20                  25                  30          


Gln Ala Glu Asp Leu Gly Pro Asp Thr Leu Asp Ser Leu Gln Arg Leu 
        35                  40                  45              


Phe Leu Ile Ile Ser Ala Thr Lys Tyr Ser Arg Arg Leu Glu Lys Thr 
    50                  55                  60                  


Cys Val Asp Leu Leu Gln Ala Thr Leu Gly Leu Pro Ala Cys Pro Glu 
65                  70                  75                  80  


Gln Leu Gln Val Leu Cys Ala Ala Ile Leu Arg Glu Met Ser Pro Ser 
                85                  90                  95      


Asp Ser Leu Ser Leu Ala Trp Asp His Thr Gln Asn Ser Arg Gln Leu 
            100                 105                 110         


Ser Leu Val Ala Ser Val Leu Leu Ala Gln Gly Asp Arg Asn Glu Glu 
        115                 120                 125             


Val Arg Ala Val Gly Gln Gly Val Leu Arg Ala Leu Glu Ser Arg Gln 
    130                 135                 140                 


Pro Glu Gly Pro Ser Leu Arg His Leu Leu Pro Val Met Ala Lys Val 
145                 150                 155                 160 


Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln Ala Thr Leu Leu 
                165                 170                 175     


Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser Leu Gln Gln Gly 
            180                 185                 190         


Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg Ala Arg Gln Pro 
        195                 200                 205             


Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr Asp Phe Phe Thr 
    210                 215                 220                 


Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln Trp Leu Asn Val 
225                 230                 235                 240 


Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu 
                245                 250                 255     


Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser 
            260                 265                 270         


Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro 
        275                 280                 285             


Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu 
    290                 295                 300                 


Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu 
305                 310                 315                 320 


Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys 
                325                 330                 335     


Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala 
            340                 345                 350         


Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu 
        355                 360                 365             


Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp 
    370                 375                 380                 


Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln 
385                 390                 395                 400 


Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp 
                405                 410                 415     


Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe 
            420                 425                 430         


Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser 
        435                 440                 445             


Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu 
    450                 455                 460                 


Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu 
465                 470                 475                 480 


Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp 
                485                 490                 495     


Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro 
            500                 505                 510         


Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly 
        515                 520                 525             


Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala 
    530                 535                 540                 


Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu 
545                 550                 555                 560 


Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile 
                565                 570                 575     


Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro 
            580                 585                 590         


Ala Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe 
        595                 600                 605             


Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg 
    610                 615                 620                 


Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala 
625                 630                 635                 640 


Ser Leu Val Thr Ser Val Val Trp Ala Ile Gly Glu Tyr Leu Ser Val 
                645                 650                 655     


Thr Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile Asn Lys Phe Phe Glu 
            660                 665                 670         


Ala Leu Glu Ala Leu Leu Phe Glu Val Thr Gln Cys Arg Pro Ser Ala 
        675                 680                 685             


Ala Leu Pro Arg Cys Pro Pro Gln Val Val Thr Val Leu Met Thr Thr 
    690                 695                 700                 


Leu Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu Ile Pro Arg Ala Ser 
705                 710                 715                 720 


Leu Leu Leu Ser Lys Met Arg Thr Leu Ala His Ser Pro Ala Thr Ser 
                725                 730                 735     


Ser Thr His Ser Glu Glu Gly Ala Glu Ala Ile Arg Thr Arg Ala Thr 
            740                 745                 750         


Glu Leu Leu Thr Leu Leu Lys Met Pro Ser Val Ala Gln Phe Val Leu 
        755                 760                 765             


Thr Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr His Arg Asp Ala Asn 
    770                 775                 780                 


Thr Ala Leu Pro Leu Ala Leu Arg Thr Val Ser Arg Leu Val Glu Arg 
785                 790                 795                 800 


Glu Ala Gly Leu Met Pro Gly 
                805         


<210>  615
<211>  1194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APAF1__Homo_sapiens__NP_001151

<400>  615

Met Asp Ala Lys Ala Arg Asn Cys Leu Leu Gln His Arg Glu Ala Leu 
1               5                   10                  15      


Glu Lys Asp Ile Lys Thr Ser Tyr Ile Met Asp His Met Ile Ser Asp 
            20                  25                  30          


Gly Phe Leu Thr Ile Ser Glu Glu Glu Lys Val Arg Asn Glu Pro Thr 
        35                  40                  45              


Gln Gln Gln Arg Ala Ala Met Leu Ile Lys Met Ile Leu Lys Lys Asp 
    50                  55                  60                  


Asn Asp Ser Tyr Val Ser Phe Tyr Asn Ala Leu Leu His Glu Gly Tyr 
65                  70                  75                  80  


Lys Asp Leu Ala Ala Leu Leu His Asp Gly Ile Pro Val Val Ser Ser 
                85                  90                  95      


Ser Ser Val Arg Thr Val Leu Cys Glu Gly Gly Val Pro Gln Arg Pro 
            100                 105                 110         


Val Val Phe Val Thr Arg Lys Lys Leu Val Asn Ala Ile Gln Gln Lys 
        115                 120                 125             


Leu Ser Lys Leu Lys Gly Glu Pro Gly Trp Val Thr Ile His Gly Met 
    130                 135                 140                 


Ala Gly Cys Gly Lys Ser Val Leu Ala Ala Glu Ala Val Arg Asp His 
145                 150                 155                 160 


Ser Leu Leu Glu Gly Cys Phe Pro Gly Gly Val His Trp Val Ser Val 
                165                 170                 175     


Gly Lys Gln Asp Lys Ser Gly Leu Leu Met Lys Leu Gln Asn Leu Cys 
            180                 185                 190         


Thr Arg Leu Asp Gln Asp Glu Ser Phe Ser Gln Arg Leu Pro Leu Asn 
        195                 200                 205             


Ile Glu Glu Ala Lys Asp Arg Leu Arg Ile Leu Met Leu Arg Lys His 
    210                 215                 220                 


Pro Arg Ser Leu Leu Ile Leu Asp Asp Val Trp Asp Ser Trp Val Leu 
225                 230                 235                 240 


Lys Ala Phe Asp Ser Gln Cys Gln Ile Leu Leu Thr Thr Arg Asp Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Val Met Gly Pro Lys Tyr Val Val Pro Val Glu 
            260                 265                 270         


Ser Ser Leu Gly Lys Glu Lys Gly Leu Glu Ile Leu Ser Leu Phe Val 
        275                 280                 285             


Asn Met Lys Lys Ala Asp Leu Pro Glu Gln Ala His Ser Ile Ile Lys 
    290                 295                 300                 


Glu Cys Lys Gly Ser Pro Leu Val Val Ser Leu Ile Gly Ala Leu Leu 
305                 310                 315                 320 


Arg Asp Phe Pro Asn Arg Trp Glu Tyr Tyr Leu Lys Gln Leu Gln Asn 
                325                 330                 335     


Lys Gln Phe Lys Arg Ile Arg Lys Ser Ser Ser Tyr Asp Tyr Glu Ala 
            340                 345                 350         


Leu Asp Glu Ala Met Ser Ile Ser Val Glu Met Leu Arg Glu Asp Ile 
        355                 360                 365             


Lys Asp Tyr Tyr Thr Asp Leu Ser Ile Leu Gln Lys Asp Val Lys Val 
    370                 375                 380                 


Pro Thr Lys Val Leu Cys Ile Leu Trp Asp Met Glu Thr Glu Glu Val 
385                 390                 395                 400 


Glu Asp Ile Leu Gln Glu Phe Val Asn Lys Ser Leu Leu Phe Cys Asp 
                405                 410                 415     


Arg Asn Gly Lys Ser Phe Arg Tyr Tyr Leu His Asp Leu Gln Val Asp 
            420                 425                 430         


Phe Leu Thr Glu Lys Asn Cys Ser Gln Leu Gln Asp Leu His Lys Lys 
        435                 440                 445             


Ile Ile Thr Gln Phe Gln Arg Tyr His Gln Pro His Thr Leu Ser Pro 
    450                 455                 460                 


Asp Gln Glu Asp Cys Met Tyr Trp Tyr Asn Phe Leu Ala Tyr His Met 
465                 470                 475                 480 


Ala Ser Ala Lys Met His Lys Glu Leu Cys Ala Leu Met Phe Ser Leu 
                485                 490                 495     


Asp Trp Ile Lys Ala Lys Thr Glu Leu Val Gly Pro Ala His Leu Ile 
            500                 505                 510         


His Glu Phe Val Glu Tyr Arg His Ile Leu Asp Glu Lys Asp Cys Ala 
        515                 520                 525             


Val Ser Glu Asn Phe Gln Glu Phe Leu Ser Leu Asn Gly His Leu Leu 
    530                 535                 540                 


Gly Arg Gln Pro Phe Pro Asn Ile Val Gln Leu Gly Leu Cys Glu Pro 
545                 550                 555                 560 


Glu Thr Ser Glu Val Tyr Gln Gln Ala Lys Leu Gln Ala Lys Gln Glu 
                565                 570                 575     


Val Asp Asn Gly Met Leu Tyr Leu Glu Trp Ile Asn Lys Lys Asn Ile 
            580                 585                 590         


Thr Asn Leu Ser Arg Leu Val Val Arg Pro His Thr Asp Ala Val Tyr 
        595                 600                 605             


His Ala Cys Phe Ser Glu Asp Gly Gln Arg Ile Ala Ser Cys Gly Ala 
    610                 615                 620                 


Asp Lys Thr Leu Gln Val Phe Lys Ala Glu Thr Gly Glu Lys Leu Leu 
625                 630                 635                 640 


Glu Ile Lys Ala His Glu Asp Glu Val Leu Cys Cys Ala Phe Ser Thr 
                645                 650                 655     


Asp Asp Arg Phe Ile Ala Thr Cys Ser Val Asp Lys Lys Val Lys Ile 
            660                 665                 670         


Trp Asn Ser Met Thr Gly Glu Leu Val His Thr Tyr Asp Glu His Ser 
        675                 680                 685             


Glu Gln Val Asn Cys Cys His Phe Thr Asn Ser Ser His His Leu Leu 
    690                 695                 700                 


Leu Ala Thr Gly Ser Ser Asp Cys Phe Leu Lys Leu Trp Asp Leu Asn 
705                 710                 715                 720 


Gln Lys Glu Cys Arg Asn Thr Met Phe Gly His Thr Asn Ser Val Asn 
                725                 730                 735     


His Cys Arg Phe Ser Pro Asp Asp Lys Leu Leu Ala Ser Cys Ser Ala 
            740                 745                 750         


Asp Gly Thr Leu Lys Leu Trp Asp Ala Thr Ser Ala Asn Glu Arg Lys 
        755                 760                 765             


Ser Ile Asn Val Lys Gln Phe Phe Leu Asn Leu Glu Asp Pro Gln Glu 
    770                 775                 780                 


Asp Met Glu Val Ile Val Lys Cys Cys Ser Trp Ser Ala Asp Gly Ala 
785                 790                 795                 800 


Arg Ile Met Val Ala Ala Lys Asn Lys Ile Phe Leu Trp Asn Thr Asp 
                805                 810                 815     


Ser Arg Ser Lys Val Ala Asp Cys Arg Gly His Leu Ser Trp Val His 
            820                 825                 830         


Gly Val Met Phe Ser Pro Asp Gly Ser Ser Phe Leu Thr Ser Ser Asp 
        835                 840                 845             


Asp Gln Thr Ile Arg Leu Trp Glu Thr Lys Lys Val Cys Lys Asn Ser 
    850                 855                 860                 


Ala Val Met Leu Lys Gln Glu Val Asp Val Val Phe Gln Glu Asn Glu 
865                 870                 875                 880 


Val Met Val Leu Ala Val Asp His Ile Arg Arg Leu Gln Leu Ile Asn 
                885                 890                 895     


Gly Arg Thr Gly Gln Ile Asp Tyr Leu Thr Glu Ala Gln Val Ser Cys 
            900                 905                 910         


Cys Cys Leu Ser Pro His Leu Gln Tyr Ile Ala Phe Gly Asp Glu Asn 
        915                 920                 925             


Gly Ala Ile Glu Ile Leu Glu Leu Val Asn Asn Arg Ile Phe Gln Ser 
    930                 935                 940                 


Arg Phe Gln His Lys Lys Thr Val Trp His Ile Gln Phe Thr Ala Asp 
945                 950                 955                 960 


Glu Lys Thr Leu Ile Ser Ser Ser Asp Asp Ala Glu Ile Gln Val Trp 
                965                 970                 975     


Asn Trp Gln Leu Asp Lys Cys Ile Phe Leu Arg Gly His Gln Glu Thr 
            980                 985                 990         


Val Lys Asp Phe Arg Leu Leu Lys  Asn Ser Arg Leu Leu  Ser Trp Ser 
        995                 1000                 1005             


Phe Asp  Gly Thr Val Lys Val  Trp Asn Ile Ile Thr  Gly Asn Lys 
    1010                 1015                 1020             


Glu Lys  Asp Phe Val Cys His  Gln Gly Thr Val Leu  Ser Cys Asp 
    1025                 1030                 1035             


Ile Ser  His Asp Ala Thr Lys  Phe Ser Ser Thr Ser  Ala Asp Lys 
    1040                 1045                 1050             


Thr Ala  Lys Ile Trp Ser Phe  Asp Leu Leu Leu Pro  Leu His Glu 
    1055                 1060                 1065             


Leu Arg  Gly His Asn Gly Cys  Val Arg Cys Ser Ala  Phe Ser Val 
    1070                 1075                 1080             


Asp Ser  Thr Leu Leu Ala Thr  Gly Asp Asp Asn Gly  Glu Ile Arg 
    1085                 1090                 1095             


Ile Trp  Asn Val Ser Asn Gly  Glu Leu Leu His Leu  Cys Ala Pro 
    1100                 1105                 1110             


Leu Ser  Glu Glu Gly Ala Ala  Thr His Gly Gly Trp  Val Thr Asp 
    1115                 1120                 1125             


Leu Cys  Phe Ser Pro Asp Gly  Lys Met Leu Ile Ser  Ala Gly Gly 
    1130                 1135                 1140             


Tyr Ile  Lys Trp Trp Asn Val  Val Thr Gly Glu Ser  Ser Gln Thr 
    1145                 1150                 1155             


Phe Tyr  Thr Asn Gly Thr Asn  Leu Lys Lys Ile His  Val Ser Pro 
    1160                 1165                 1170             


Asp Phe  Lys Thr Tyr Val Thr  Val Asp Asn Leu Gly  Ile Leu Tyr 
    1175                 1180                 1185             


Ile Leu  Gln Thr Leu Glu 
    1190                 


<210>  616
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APBA1__Homo_sapiens__XP_011516919

<400>  616

Met Asn His Leu Glu Gly Ser Ala Glu Val Glu Val Thr Asp Glu Ala 
1               5                   10                  15      


Ala Gly Gly Glu Val Asn Glu Ser Val Glu Ala Asp Leu Glu His Pro 
            20                  25                  30          


Glu Val Glu Glu Glu Gln Gln Gln Pro Pro Gln Gln Gln His Tyr Val 
        35                  40                  45              


Gly Arg His Gln Arg Gly Arg Ala Leu Glu Asp Leu Arg Ala Gln Leu 
    50                  55                  60                  


Gly Gln Glu Glu Glu Glu Arg Gly Glu Cys Leu Ala Arg Ser Ala Ser 
65                  70                  75                  80  


Thr Glu Ser Gly Phe His Asn His Thr Asp Thr Ala Glu Gly Asp Val 
                85                  90                  95      


Ile Ala Ala Ala Arg Asp Gly Tyr Asp Ala Glu Arg Ala Gln Asp Pro 
            100                 105                 110         


Glu Asp Glu Ser Ala Tyr Ala Val Gln Tyr Arg Pro Glu Ala Glu Glu 
        115                 120                 125             


Tyr Thr Glu Gln Ala Glu Ala Glu His Ala Glu Ala Thr His Arg Arg 
    130                 135                 140                 


Ala Leu Pro Asn His Leu His Phe His Ser Leu Glu His Glu Glu Ala 
145                 150                 155                 160 


Met Asn Ala Ala Tyr Ser Gly Tyr Val Tyr Thr His Arg Leu Phe His 
                165                 170                 175     


Arg Gly Glu Asp Glu Pro Tyr Ser Glu Pro Tyr Ala Asp Tyr Gly Gly 
            180                 185                 190         


Leu Gln Glu His Val Tyr Glu Glu Ile Gly Asp Ala Pro Glu Leu Asp 
        195                 200                 205             


Ala Arg Asp Gly Leu Arg Leu Tyr Glu Gln Glu Arg Asp Glu Ala Ala 
    210                 215                 220                 


Ala Tyr Arg Gln Glu Ala Leu Gly Ala Arg Leu His His Tyr Asp Glu 
225                 230                 235                 240 


Arg Ser Asp Gly Glu Ser Asp Ser Pro Glu Lys Glu Ala Glu Phe Ala 
                245                 250                 255     


Pro Tyr Pro Arg Met Asp Ser Tyr Glu Gln Glu Glu Asp Ile Asp Gln 
            260                 265                 270         


Ile Val Ala Glu Val Lys Gln Ser Met Ser Ser Gln Ser Leu Asp Lys 
        275                 280                 285             


Ala Ala Glu Asp Met Pro Glu Ala Glu Gln Asp Leu Glu Arg Pro Pro 
    290                 295                 300                 


Thr Pro Ala Gly Gly Arg Pro Asp Ser Pro Gly Leu Gln Ala Pro Ala 
305                 310                 315                 320 


Gly Gln Gln Arg Ala Val Gly Pro Ala Gly Gly Gly Glu Ala Gly Gln 
                325                 330                 335     


Arg Tyr Ser Lys Glu Lys Arg Asp Ala Ile Ser Leu Ala Ile Lys Asp 
            340                 345                 350         


Ile Lys Glu Ala Ile Glu Glu Val Lys Thr Arg Thr Ile Arg Ser Pro 
        355                 360                 365             


Tyr Thr Pro Asp Glu Pro Lys Glu Pro Ile Trp Val Met Arg Gln Asp 
    370                 375                 380                 


Ile Ser Pro Thr Arg Asp Cys Asp Asp Gln Arg Pro Met Asp Gly Asp 
385                 390                 395                 400 


Ser Pro Ser Pro Gly Ser Ser Ser Pro Leu Gly Ala Glu Ser Ser Ser 
                405                 410                 415     


Thr Ser Leu His Pro Ser Asp Pro Val Glu Ala Ser Thr Asn Lys Glu 
            420                 425                 430         


Ser Arg Lys Ser Leu Ala Ser Phe Pro Thr Tyr Val Glu Val Pro Gly 
        435                 440                 445             


Pro Cys Asp Pro Glu Asp Leu Ile Asp Gly Ile Ile Phe Ala Ala Asn 
    450                 455                 460                 


Tyr Leu Gly Ser Thr Gln Leu Leu Ser Asp Lys Thr Pro Ser Lys Asn 
465                 470                 475                 480 


Val Arg Met Met Gln Ala Gln Glu Ala Val Ser Arg Ile Lys Met Ala 
                485                 490                 495     


Gln Lys Leu Ala Lys Ser Arg Lys Lys Ala Pro Glu Gly Glu Ser Gln 
            500                 505                 510         


Pro Met Thr Glu Val Asp Leu Phe Ile Ser Thr Gln Arg Ile Lys Val 
        515                 520                 525             


Leu Asn Ala Asp Thr Gln Glu Thr Met Met Asp His Pro Leu Arg Thr 
    530                 535                 540                 


Ile Ser Tyr Ile Ala Asp Ile Gly Asn Ile Val Val Leu Met Ala Arg 
545                 550                 555                 560 


Arg Arg Met Pro Arg Ser Asn Ser Gln Glu Asn Val Glu Ala Ser His 
                565                 570                 575     


Pro Ser Gln Asp Gly Lys Arg Gln Tyr Lys Met Ile Cys His Val Phe 
            580                 585                 590         


Glu Ser Glu Asp Ala Gln Leu Ile Ala Gln Ser Ile Gly Gln Ala Phe 
        595                 600                 605             


Ser Val Ala Tyr Gln Glu Phe Leu Arg Ala Asn Gly Ile Asn Pro Glu 
    610                 615                 620                 


Asp Leu Ser Gln Lys Glu Tyr Ser Asp Leu Leu Asn Thr Gln Asp Met 
625                 630                 635                 640 


Tyr Asn Asp Asp Leu Ile His Phe Ser Lys Ser Glu Asn Cys Lys Asp 
                645                 650                 655     


Val Phe Ile Glu Lys Gln Lys Gly Glu Ile Leu Gly Val Val Ile Val 
            660                 665                 670         


Glu Ser Gly Trp Gly Ser Ile Leu Pro Thr Val Ile Ile Ala Asn Met 
        675                 680                 685             


Met His Gly Gly Pro Ala Glu Lys Ser Gly Lys Leu Asn Ile Gly Asp 
    690                 695                 700                 


Gln Ile Met Ser Ile Asn Gly Thr Ser Leu Val Gly Leu Pro Leu Ser 
705                 710                 715                 720 


Thr Cys Gln Ser Ile Ile Lys Gly Leu Lys Asn Gln Ser Arg Val Lys 
                725                 730                 735     


Leu Asn Ile Val Arg Cys Pro Pro Val Thr Thr Val Leu Ile Arg Arg 
            740                 745                 750         


Pro Asp Leu Arg Tyr Gln Leu Gly Phe Ser Val Gln Asn Gly Ile Ile 
        755                 760                 765             


Cys Ser Leu Met Arg Gly Gly Ile Ala Glu Arg Gly Gly Val Arg Val 
    770                 775                 780                 


Gly His Arg Ile Ile Glu Ile Asn Gly Gln Ser Val Val Ala Thr Pro 
785                 790                 795                 800 


His Glu Lys Ile Val His Ile Leu Ser Asn Ala Val Gly Glu Ile His 
                805                 810                 815     


Met Lys Thr Met Pro Ala Ala Met Tyr Arg Leu Leu Thr Ala Gln Glu 
            820                 825                 830         


Gln Pro Val Tyr Ile 
        835         


<210>  617
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APBA2__Homo_sapiens__XP_006725606

<400>  617

Met Ala His Arg Lys Leu Glu Ser Val Gly Ser Gly Met Leu Asp His 
1               5                   10                  15      


Arg Val Arg Pro Gly Pro Val Pro His Ser Gln Glu Pro Glu Ser Glu 
            20                  25                  30          


Asp Met Glu Leu Pro Leu Glu Gly Tyr Val Pro Glu Gly Leu Glu Leu 
        35                  40                  45              


Ala Ala Leu Arg Pro Glu Ser Pro Ala Pro Glu Glu Gln Glu Cys His 
    50                  55                  60                  


Asn His Ser Pro Asp Gly Asp Ser Ser Ser Asp Tyr Val Asn Asn Thr 
65                  70                  75                  80  


Ser Glu Glu Glu Asp Tyr Asp Glu Gly Leu Pro Glu Glu Glu Glu Gly 
                85                  90                  95      


Ile Thr Tyr Tyr Ile Arg Tyr Cys Pro Glu Asp Asp Ser Tyr Leu Glu 
            100                 105                 110         


Gly Met Asp Cys Asn Gly Glu Glu Tyr Leu Ala His Ser Ala His Pro 
        115                 120                 125             


Val Asp Thr Asp Glu Cys Gln Glu Ala Val Glu Glu Trp Thr Asp Ser 
    130                 135                 140                 


Ala Gly Pro His Pro His Gly His Glu Ala Glu Gly Ser Gln Asp Tyr 
145                 150                 155                 160 


Pro Asp Gly Gln Leu Pro Ile Pro Glu Asp Glu Pro Ser Val Leu Glu 
                165                 170                 175     


Ala His Asp Gln Glu Glu Asp Gly His Tyr Cys Ala Ser Lys Glu Gly 
            180                 185                 190         


Tyr Gln Asp Tyr Tyr Pro Glu Glu Ala Asn Gly Asn Thr Gly Ala Ser 
        195                 200                 205             


Pro Tyr Arg Leu Arg Arg Gly Asp Gly Asp Leu Glu Asp Gln Glu Glu 
    210                 215                 220                 


Asp Ile Asp Gln Ile Val Ala Glu Ile Lys Met Ser Leu Ser Met Thr 
225                 230                 235                 240 


Ser Ile Thr Ser Ala Ser Glu Ala Ser Pro Glu His Gly Pro Glu Pro 
                245                 250                 255     


Gly Pro Glu Asp Ser Val Glu Ala Cys Pro Pro Ile Lys Ala Ser Cys 
            260                 265                 270         


Ser Pro Ser Arg His Glu Ala Arg Pro Lys Ser Leu Asn Leu Leu Pro 
        275                 280                 285             


Glu Ala Lys His Pro Gly Asp Pro Gln Arg Gly Phe Lys Pro Lys Thr 
    290                 295                 300                 


Arg Thr Pro Glu Glu Arg Leu Lys Trp Pro His Glu Gln Val Cys Asn 
305                 310                 315                 320 


Gly Leu Glu Gln Pro Arg Lys Gln Gln Arg Ser Asp Leu Asn Gly Pro 
                325                 330                 335     


Val Asp Asn Asn Asn Ile Pro Glu Thr Lys Lys Val Ala Ser Phe Pro 
            340                 345                 350         


Ser Phe Val Ala Val Pro Gly Pro Cys Glu Pro Glu Asp Leu Ile Asp 
        355                 360                 365             


Gly Ile Ile Phe Ala Ala Asn Tyr Leu Gly Ser Thr Gln Leu Leu Ser 
    370                 375                 380                 


Glu Arg Asn Pro Ser Lys Asn Ile Arg Met Met Gln Ala Gln Glu Ala 
385                 390                 395                 400 


Val Ser Arg Val Lys Asn Ser Glu Gly Asp Ala Gln Thr Leu Thr Glu 
                405                 410                 415     


Val Asp Leu Phe Ile Ser Thr Gln Arg Ile Lys Val Leu Asn Ala Asp 
            420                 425                 430         


Thr Gln Glu Thr Met Met Asp His Ala Leu Arg Thr Ile Ser Tyr Ile 
        435                 440                 445             


Ala Asp Ile Gly Asn Ile Val Val Leu Met Ala Arg Arg Arg Met Pro 
    450                 455                 460                 


Arg Ser Ala Ser Gln Asp Cys Ile Glu Thr Thr Pro Gly Ala Gln Glu 
465                 470                 475                 480 


Gly Lys Lys Gln Tyr Lys Met Ile Cys His Val Phe Glu Ser Glu Asp 
                485                 490                 495     


Ala Gln Leu Ile Ala Gln Ser Ile Gly Gln Ala Phe Ser Val Ala Tyr 
            500                 505                 510         


Gln Glu Phe Leu Arg Ala Asn Gly Ile Asn Pro Glu Asp Leu Ser Gln 
        515                 520                 525             


Lys Glu Tyr Ser Asp Ile Ile Asn Thr Gln Glu Met Tyr Asn Asp Asp 
    530                 535                 540                 


Leu Ile His Phe Ser Asn Ser Glu Asn Cys Lys Glu Leu Gln Leu Glu 
545                 550                 555                 560 


Lys His Lys Gly Glu Ile Leu Gly Val Val Val Val Glu Ser Gly Trp 
                565                 570                 575     


Gly Ser Ile Leu Pro Thr Val Ile Leu Ala Asn Met Met Asn Gly Gly 
            580                 585                 590         


Pro Ala Ala Arg Ser Gly Lys Leu Ser Ile Gly Asp Gln Ile Met Ser 
        595                 600                 605             


Ile Asn Gly Thr Ser Leu Val Gly Leu Pro Leu Ala Thr Cys Gln Gly 
    610                 615                 620                 


Ile Ile Lys Gly Leu Lys Asn Gln Thr Gln Val Lys Leu Asn Ile Val 
625                 630                 635                 640 


Ser Cys Pro Pro Val Thr Thr Val Leu Ile Lys Arg Pro Asp Leu Lys 
                645                 650                 655     


Tyr Gln Leu Gly Phe Ser Val Gln Asn Gly Ile Ile Cys Ser Leu Met 
            660                 665                 670         


Arg Gly Gly Ile Ala Glu Arg Gly Gly Val Arg Val Gly His Arg Ile 
        675                 680                 685             


Ile Glu Ile Asn Gly Gln Ser Val Val Ala Thr Ala His Glu Lys Ile 
    690                 695                 700                 


Val Gln Ala Leu Ser Asn Ser Val Gly Glu Ile His Met Lys Thr Met 
705                 710                 715                 720 


Pro Ala Ala Met Phe Arg Leu Leu Thr Gly Gln Glu Thr Pro Leu Tyr 
                725                 730                 735     


Ile 
    


<210>  618
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APBA3__Homo_sapiens__NP_004877

<400>  618

Met Asp Phe Pro Thr Ile Ser Arg Ser Pro Ser Gly Pro Pro Ala Met 
1               5                   10                  15      


Asp Leu Glu Gly Pro Arg Asp Ile Leu Val Pro Ser Glu Asp Leu Thr 
            20                  25                  30          


Pro Asp Ser Gln Trp Asp Pro Met Pro Gly Gly Pro Gly Ser Leu Ser 
        35                  40                  45              


Arg Met Glu Leu Asp Glu Ser Ser Leu Gln Glu Leu Val Gln Gln Phe 
    50                  55                  60                  


Glu Ala Leu Pro Gly Asp Leu Val Gly Pro Ser Pro Gly Gly Ala Pro 
65                  70                  75                  80  


Cys Pro Leu His Ile Ala Thr Gly His Gly Leu Ala Ser Gln Glu Ile 
                85                  90                  95      


Ala Asp Ala His Gly Leu Leu Ser Ala Glu Ala Gly Arg Asp Asp Leu 
            100                 105                 110         


Leu Gly Leu Leu His Cys Glu Glu Cys Pro Pro Ser Gln Thr Gly Pro 
        115                 120                 125             


Glu Glu Pro Leu Glu Pro Ala Pro Arg Leu Leu Gln Pro Pro Glu Asp 
    130                 135                 140                 


Pro Asp Glu Asp Ser Asp Ser Pro Glu Trp Val Glu Gly Ala Ser Ala 
145                 150                 155                 160 


Glu Gln Glu Gly Ser Arg Ser Ser Ser Ser Ser Pro Glu Pro Trp Leu 
                165                 170                 175     


Glu Thr Val Pro Leu Val Thr Pro Glu Glu Pro Pro Ala Gly Ala Gln 
            180                 185                 190         


Ser Pro Glu Thr Leu Ala Ser Tyr Pro Ala Pro Gln Glu Val Pro Gly 
        195                 200                 205             


Pro Cys Asp His Glu Asp Leu Leu Asp Gly Val Ile Phe Gly Ala Arg 
    210                 215                 220                 


Tyr Leu Gly Ser Thr Gln Leu Val Ser Glu Arg Asn Pro Pro Thr Ser 
225                 230                 235                 240 


Thr Arg Met Ala Gln Ala Arg Glu Ala Met Asp Arg Val Lys Ala Pro 
                245                 250                 255     


Asp Gly Glu Thr Gln Pro Met Thr Glu Val Asp Leu Phe Val Ser Thr 
            260                 265                 270         


Lys Arg Ile Lys Val Leu Thr Ala Asp Ser Gln Glu Ala Met Met Asp 
        275                 280                 285             


His Ala Leu His Thr Ile Ser Tyr Thr Ala Asp Ile Gly Cys Val Leu 
    290                 295                 300                 


Val Leu Met Ala Arg Arg Arg Leu Ala Arg Arg Pro Ala Pro Gln Asp 
305                 310                 315                 320 


His Gly Arg Arg Leu Tyr Lys Met Leu Cys His Val Phe Tyr Ala Glu 
                325                 330                 335     


Asp Ala Gln Leu Ile Ala Gln Ala Ile Gly Gln Ala Phe Ala Ala Ala 
            340                 345                 350         


Tyr Ser Gln Phe Leu Arg Glu Ser Gly Ile Asp Pro Ser Gln Val Gly 
        355                 360                 365             


Val His Pro Ser Pro Gly Ala Cys His Leu His Asn Gly Asp Leu Asp 
    370                 375                 380                 


His Phe Ser Asn Ser Asp Asn Cys Arg Glu Val His Leu Glu Lys Arg 
385                 390                 395                 400 


Arg Gly Glu Gly Leu Gly Val Ala Leu Val Glu Ser Gly Trp Gly Ser 
                405                 410                 415     


Leu Leu Pro Thr Ala Val Ile Ala Asn Leu Leu His Gly Gly Pro Ala 
            420                 425                 430         


Glu Arg Ser Gly Ala Leu Ser Ile Gly Asp Arg Leu Thr Ala Ile Asn 
        435                 440                 445             


Gly Thr Ser Leu Val Gly Leu Pro Leu Ala Ala Cys Gln Ala Ala Val 
    450                 455                 460                 


Arg Glu Thr Lys Ser Gln Thr Ser Val Thr Leu Ser Ile Val His Cys 
465                 470                 475                 480 


Pro Pro Val Thr Thr Ala Ile Ile His Arg Pro His Ala Arg Glu Gln 
                485                 490                 495     


Leu Gly Phe Cys Val Glu Asp Gly Ile Ile Cys Ser Leu Leu Arg Gly 
            500                 505                 510         


Gly Ile Ala Glu Arg Gly Gly Ile Arg Val Gly His Arg Ile Ile Glu 
        515                 520                 525             


Ile Asn Gly Gln Ser Val Val Ala Thr Pro His Ala Arg Ile Ile Glu 
    530                 535                 540                 


Leu Leu Thr Glu Ala Tyr Gly Glu Val His Ile Lys Thr Met Pro Ala 
545                 550                 555                 560 


Ala Thr Tyr Arg Leu Leu Thr Gly Gln Glu Gln Pro Val Tyr Leu 
                565                 570                 575 


<210>  619
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APBB1__Homo_sapiens__NP_001244248

<400>  619

Met Ser Ala Met Phe Ser Gln Asp Phe Phe Leu Ala Ile Ile Leu Gln 
1               5                   10                  15      


Asp Ser Ser Ala Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp 
            20                  25                  30          


Ser Asp Leu Pro Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr 
        35                  40                  45              


Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly 
    50                  55                  60                  


Arg Ala Ser Pro Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu 
65                  70                  75                  80  


Thr Trp Thr Gly Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe 
                85                  90                  95      


Trp Lys Asp Glu Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys 
            100                 105                 110         


Glu Pro Glu Glu Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro 
        115                 120                 125             


Glu Pro Leu Pro Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn 
    130                 135                 140                 


Pro Gly Ile Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met 
145                 150                 155                 160 


Thr Glu Glu Glu Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn 
                165                 170                 175     


Cys Ile Arg Gln Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met 
            180                 185                 190         


Ser Gly Gly Trp Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp 
        195                 200                 205             


Glu Thr Leu Lys Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala 
    210                 215                 220                 


Gln Pro Ile Ile Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly 
225                 230                 235                 240 


Arg Glu Arg Asp Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met 
                245                 250                 255     


Leu Lys Cys His Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala 
            260                 265                 270         


Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn 
        275                 280                 285             


Ala Arg Cys Leu Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val 
    290                 295                 300                 


Asp Val Pro Phe Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val 
305                 310                 315                 320 


Gln Lys Phe Gln Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro 
                325                 330                 335     


Val Gly Val Asp Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser 
            340                 345                 350         


Ser Ser Arg Glu Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala 
        355                 360                 365             


Thr Leu Thr Ile Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys 
    370                 375                 380                 


Arg Val Arg Phe Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr 
385                 390                 395                 400 


Phe Ala Phe Ile Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met 
                405                 410                 415     


Phe Trp Cys Glu Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala 
            420                 425                 430         


Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala 
        435                 440                 445             


Ser Thr Ser Cys Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg 
    450                 455                 460                 


Val Gly Trp Thr Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu 
465                 470                 475                 480 


Lys Pro Lys Arg Leu Gly Ala His Thr Pro 
                485                 490 


<210>  620
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APBB1IP__Homo_sapiens__XP_006717514

<400>  620

Met Gly Glu Ser Ser Glu Asp Ile Asp Gln Met Phe Ser Thr Leu Leu 
1               5                   10                  15      


Gly Glu Met Asp Leu Leu Thr Gln Ser Leu Gly Val Asp Thr Leu Pro 
            20                  25                  30          


Pro Pro Asp Pro Asn Pro Pro Arg Ala Glu Phe Asn Tyr Ser Val Gly 
        35                  40                  45              


Phe Lys Asp Leu Asn Glu Ser Leu Asn Ala Leu Glu Asp Gln Asp Leu 
    50                  55                  60                  


Asp Ala Leu Met Ala Asp Leu Val Ala Asp Ile Ser Glu Ala Glu Gln 
65                  70                  75                  80  


Arg Thr Ile Gln Ala Gln Lys Glu Ser Leu Gln Asn Gln His His Ser 
                85                  90                  95      


Ala Ser Leu Gln Ala Ser Ile Phe Ser Gly Ala Ala Ser Leu Gly Tyr 
            100                 105                 110         


Gly Thr Asn Val Ala Ala Thr Gly Ile Ser Gln Tyr Glu Asp Asp Leu 
        115                 120                 125             


Pro Pro Pro Pro Ala Asp Pro Val Leu Asp Leu Pro Leu Pro Pro Pro 
    130                 135                 140                 


Pro Pro Glu Pro Leu Ser Gln Glu Glu Glu Glu Ala Gln Ala Lys Ala 
145                 150                 155                 160 


Asp Lys Ile Lys Leu Ala Leu Glu Lys Leu Lys Glu Ala Lys Val Lys 
                165                 170                 175     


Lys Leu Val Val Lys Val His Met Asn Asp Asn Ser Thr Lys Ser Leu 
            180                 185                 190         


Met Val Asp Glu Arg Gln Leu Ala Arg Asp Val Leu Asp Asn Leu Phe 
        195                 200                 205             


Glu Lys Thr His Cys Asp Cys Asn Val Asp Trp Cys Leu Tyr Glu Ile 
    210                 215                 220                 


Tyr Pro Glu Leu Gln Ile Glu Arg Phe Phe Glu Asp His Glu Asn Val 
225                 230                 235                 240 


Val Glu Val Leu Ser Asp Trp Thr Arg Asp Thr Glu Asn Lys Ile Leu 
                245                 250                 255     


Phe Leu Glu Lys Glu Glu Lys Tyr Ala Val Phe Lys Asn Pro Gln Asn 
            260                 265                 270         


Phe Tyr Leu Asp Asn Arg Gly Lys Lys Glu Ser Lys Glu Thr Asn Glu 
        275                 280                 285             


Lys Met Asn Ala Lys Asn Lys Glu Ser Leu Leu Glu Glu Ser Phe Cys 
    290                 295                 300                 


Gly Thr Ser Ile Ile Val Pro Glu Leu Glu Gly Ala Leu Tyr Leu Lys 
305                 310                 315                 320 


Glu Asp Gly Lys Lys Ser Trp Lys Arg Arg Tyr Phe Leu Leu Arg Ala 
                325                 330                 335     


Ser Gly Ile Tyr Tyr Val Pro Lys Gly Lys Thr Lys Thr Ser Arg Asp 
            340                 345                 350         


Leu Ala Cys Phe Ile Gln Phe Glu Asn Val Asn Ile Tyr Tyr Gly Thr 
        355                 360                 365             


Gln His Lys Met Lys Tyr Lys Ala Pro Thr Asp Tyr Cys Phe Val Leu 
    370                 375                 380                 


Lys His Pro Gln Ile Gln Lys Glu Ser Gln Tyr Ile Lys Tyr Leu Cys 
385                 390                 395                 400 


Cys Asp Asp Thr Arg Thr Leu Asn Gln Trp Val Met Gly Ile Arg Ile 
                405                 410                 415     


Ala Lys Tyr Gly Lys Thr Leu Tyr Asp Asn Tyr Gln Arg Ala Val Ala 
            420                 425                 430         


Lys Ala Gly Leu Ala Ser Arg Trp Thr Asn Leu Gly Thr Val Asn Ala 
        435                 440                 445             


Ala Ala Pro Ala Gln Pro Ser Thr Gly Pro Lys Thr Gly Thr Thr Gln 
    450                 455                 460                 


Pro Asn Gly Gln Ile Pro Gln Ala Thr His Ser Val Ser Ala Val Leu 
465                 470                 475                 480 


Gln Glu Ala Gln Arg His Ala Glu Thr Ser Lys Asp Lys Lys Pro Ala 
                485                 490                 495     


Leu Gly Asn His His Asp Pro Ala Val Pro Arg Ala Pro His Ala Pro 
            500                 505                 510         


Lys Ser Ser Leu Pro Pro Pro Pro Pro Val Arg Arg Ser Ser Asp Thr 
        515                 520                 525             


Ser Gly Ser Pro Ala Thr Pro Leu Lys Ala Lys Gly Thr Gly Gly Gly 
    530                 535                 540                 


Gly Leu Pro Ala Pro Pro Asp Asp Phe Leu Pro Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Pro Pro Leu Asp Asp Pro Glu Leu Pro Pro Pro Pro Pro Asp Phe Met 
                565                 570                 575     


Glu Pro Pro Pro Asp Phe Val Pro Pro Pro Pro Pro Ser Tyr Ala Gly 
            580                 585                 590         


Ile Ala Gly Ser Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro 
        595                 600                 605             


Ala Pro Ala Pro Val Pro Asp Ser Ala Arg Pro Pro Pro Ala Val Ala 
    610                 615                 620                 


Lys Arg Pro Pro Val Pro Pro Lys Arg Gln Glu Asn Pro Gly His Pro 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Gly Glu Gln Asp Phe Met Ser Asp Leu Met Lys 
                645                 650                 655     


Ala Leu Gln Lys Lys Arg Gly Asn Val Ser 
            660                 665     


<210>  621
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APBB2__Homo_sapiens__NP_001159522

<400>  621

Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Thr Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Thr Thr Asp Val Thr Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Thr Pro Pro Asn Thr Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Thr Glu Thr Lys Asn Ser Thr Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys Lys Tyr Ala Leu Thr Asn Ile Gln Ala Ala Met Gly 
65                  70                  75                  80  


Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn 
                85                  90                  95      


Ile Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu 
            100                 105                 110         


Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Thr Ala Val Ile 
        115                 120                 125             


Asn Ile Thr Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp 
    130                 135                 140                 


Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg Thr Lys Ser 
145                 150                 155                 160 


Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Thr Ser Ala Arg Glu Leu Glu 
                165                 170                 175     


Gln Asn Arg Gly Asn His His Gly Thr Ala Glu Glu Lys Ser Gln Pro 
            180                 185                 190         


Val Gln Gly Gln Ala Ser Thr Ile Ile Gly Asn Gly Asp Leu Leu Leu 
        195                 200                 205             


Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro Glu Asp Gly Gln Val Ala 
    210                 215                 220                 


Thr Val Ser Ser Ser Pro Glu Thr Lys Lys Asp His Pro Lys Thr Gly 
225                 230                 235                 240 


Ala Lys Thr Asp Cys Ala Leu His Arg Ile Gln Asn Leu Ala Pro Ser 
                245                 250                 255     


Asp Glu Glu Ser Ser Trp Thr Thr Leu Ser Gln Asp Ser Ala Ser Pro 
            260                 265                 270         


Ser Ser Pro Asp Glu Thr Asp Ile Trp Ser Asp His Ser Phe Gln Thr 
        275                 280                 285             


Asp Pro Asp Leu Pro Pro Gly Trp Lys Arg Val Ser Asp Ile Ala Gly 
    290                 295                 300                 


Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Arg Pro 
305                 310                 315                 320 


Val Ser Ile Pro Ala Asp Leu Gln Gly Ser Arg Lys Gly Ser Leu Ser 
                325                 330                 335     


Ser Val Thr Pro Ser Pro Thr Pro Glu Asn Glu Lys Gln Pro Trp Ser 
            340                 345                 350         


Asp Phe Ala Val Leu Asn Gly Gly Lys Ile Asn Ser Asp Ile Trp Lys 
        355                 360                 365             


Asp Leu His Ala Ala Thr Val Asn Pro Asp Pro Ser Leu Lys Glu Phe 
    370                 375                 380                 


Glu Gly Ala Thr Leu Arg Tyr Ala Ser Leu Lys Leu Arg Asn Ala Pro 
385                 390                 395                 400 


His Pro Asp Asp Asp Asp Ser Cys Ser Ile Asn Ser Asp Pro Glu Ala 
                405                 410                 415     


Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Ala Glu Glu 
            420                 425                 430         


Asp Leu Ala Pro Gly Lys Ser Ser Val Ala Val Asn Asn Cys Ile Arg 
        435                 440                 445             


Gln Leu Ser Tyr Cys Lys Asn Asp Ile Arg Asp Thr Val Gly Ile Trp 
    450                 455                 460                 


Gly Glu Gly Lys Asp Met Tyr Leu Ile Leu Glu Asn Asp Met Leu Ser 
465                 470                 475                 480 


Leu Val Asp Pro Met Asp Arg Ser Val Leu His Ser Gln Pro Ile Val 
                485                 490                 495     


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Asn Gly Arg Asp Phe Ala 
            500                 505                 510         


Tyr Val Ala Arg Asp Lys Asp Thr Arg Ile Leu Lys Cys His Val Phe 
        515                 520                 525             


Arg Cys Asp Thr Pro Ala Lys Ala Ile Ala Thr Ser Leu His Glu Ile 
    530                 535                 540                 


Cys Ser Lys Ile Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys 
545                 550                 555                 560 


Ser Ser Leu Gln Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln 
                565                 570                 575     


Val Asp Phe Pro Thr Pro Lys Thr Glu Leu Val Gln Lys Phe His Val 
            580                 585                 590         


Gln Tyr Leu Gly Met Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile 
        595                 600                 605             


Leu Asn Ser Ala Ile Glu Asn Leu Met Thr Ser Ser Asn Lys Glu Asp 
    610                 615                 620                 


Trp Leu Ser Val Asn Met Asn Val Ala Asp Ala Thr Val Thr Val Ile 
625                 630                 635                 640 


Ser Glu Lys Asn Glu Glu Glu Val Leu Val Glu Cys Arg Val Arg Phe 
                645                 650                 655     


Leu Ser Phe Met Gly Val Gly Lys Asp Val His Thr Phe Ala Phe Ile 
            660                 665                 670         


Met Asp Thr Gly Asn Gln Arg Phe Glu Cys His Val Phe Trp Cys Glu 
        675                 680                 685             


Pro Asn Ala Gly Asn Val Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
    690                 695                 700                 


Arg Tyr Gln Lys Cys Leu Val Ala Arg Pro Pro Ser Gln Lys Val Arg 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Ala Asp Ser Val Thr Arg Arg Val Thr Thr Asn 
                725                 730                 735     


Val Lys Arg Gly Val Leu Ser Leu Ile Asp Thr Leu Lys Gln Lys Arg 
            740                 745                 750         


Pro Val Thr Glu Met Pro 
        755             


<210>  622
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APBB3__Homo_sapiens__NP_006042

<400>  622

Met Leu Gly Lys Asp Tyr Met Leu Ala Ile Ile Leu Val Asn Cys Asp 
1               5                   10                  15      


Asp Asp Leu Trp Gly Asp His Ser Leu Glu Val Glu Ala Gly Leu Pro 
            20                  25                  30          


Pro Gly Trp Arg Lys Ile His Asp Ala Ala Gly Thr Tyr Tyr Trp His 
        35                  40                  45              


Val Pro Ser Gly Ser Thr Gln Trp Gln Arg Pro Thr Trp Glu Leu Gly 
    50                  55                  60                  


Asp Ala Glu Asp Pro Gly Thr Gly Thr Glu Gly Ile Trp Gly Leu Arg 
65                  70                  75                  80  


Pro Pro Lys Gly Arg Ser Phe Ser Ser Leu Glu Ser Ser Leu Asp Arg 
                85                  90                  95      


Ser Asn Ser Leu Ser Trp Tyr Gly Gly Glu Ser Tyr Ile Gln Ser Met 
            100                 105                 110         


Glu Pro Gly Ala Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu 
        115                 120                 125             


Val Pro Glu Glu Asp Leu Ala Pro Gly Lys Ser Ser Ile Ala Val Asn 
    130                 135                 140                 


Asn Cys Ile Gln Gln Leu Ala Gln Thr Arg Ser Arg Ser Gln Pro Pro 
145                 150                 155                 160 


Asp Gly Ala Trp Gly Glu Gly Gln Asn Met Leu Met Ile Leu Lys Lys 
                165                 170                 175     


Asp Ala Met Ser Leu Val Asn Pro Leu Asp His Ser Leu Ile His Cys 
            180                 185                 190         


Gln Pro Leu Val His Ile Arg Val Trp Gly Val Gly Ser Ser Lys Gly 
        195                 200                 205             


Arg Asp Ser Pro Ile Ser Ala Pro Ala Arg Asp Phe Ala Phe Val Ala 
    210                 215                 220                 


Ser Asp Lys Asp Ser Cys Met Leu Lys Cys His Val Phe Cys Cys Asp 
225                 230                 235                 240 


Val Pro Ala Lys Ala Ile Ala Ser Ala Leu His Gly Leu Cys Ala Gln 
                245                 250                 255     


Ile Leu Ser Glu Arg Val Glu Val Ser Gly Asp Ala Ser Cys Cys Ser 
            260                 265                 270         


Pro Asp Pro Ile Ser Pro Glu Asp Leu Pro Arg Gln Val Glu Leu Leu 
        275                 280                 285             


Asp Ala Val Ser Gln Ala Ala Gln Lys Tyr Glu Ala Leu Tyr Met Gly 
    290                 295                 300                 


Thr Leu Pro Val Thr Lys Ala Met Gly Met Asp Val Leu Asn Glu Ala 
305                 310                 315                 320 


Ile Gly Thr Leu Thr Ala Arg Gly Asp Arg Asn Ala Trp Val Pro Thr 
                325                 330                 335     


Met Leu Ser Val Ser Asp Ser Leu Met Thr Ala His Pro Ile Gln Ala 
            340                 345                 350         


Glu Ala Ser Thr Glu Glu Glu Pro Leu Trp Gln Cys Pro Val Arg Leu 
        355                 360                 365             


Val Thr Phe Ile Gly Val Gly Arg Asp Pro His Thr Phe Gly Leu Ile 
    370                 375                 380                 


Ala Asp Leu Gly Arg Gln Ser Phe Gln Cys Ala Ala Phe Trp Cys Gln 
385                 390                 395                 400 


Pro His Ala Gly Gly Leu Ser Glu Ala Val Gln Ala Ala Cys Met Val 
                405                 410                 415     


Gln Tyr Gln Lys Cys Leu Val Ala Ser Ala Ala Arg Gly Lys Ala Trp 
            420                 425                 430         


Gly Ala Gln Ala Arg Ala Arg Leu Arg Leu Lys Arg Thr Ser Ser Met 
        435                 440                 445             


Asp Ser Pro Gly Gly Pro Leu Pro Leu Pro Leu Leu Lys Gly Gly Val 
    450                 455                 460                 


Gly Gly Ala Gly Ala Thr Pro Arg Lys Arg Gly Val Phe Ser Phe Leu 
465                 470                 475                 480 


Asp Ala Phe Arg Leu Lys Pro Ser Leu Leu His Met Pro 
                485                 490             


<210>  623
<211>  2327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APC2__Homo_sapiens__XP_005259532

<400>  623

Met Gly Leu Leu Gly Leu Leu Ser Leu Leu His Ser Ala Phe Phe Gly 
1               5                   10                  15      


Asp Gln Thr Leu Gln Glu Leu Lys Met Ala Ser Ser Val Ala Pro Tyr 
            20                  25                  30          


Glu Gln Leu Val Arg Gln Val Glu Ala Leu Lys Ala Glu Asn Ser His 
        35                  40                  45              


Leu Arg Gln Glu Leu Arg Asp Asn Ser Ser His Leu Ser Lys Leu Glu 
    50                  55                  60                  


Thr Glu Thr Ser Gly Met Lys Glu Val Leu Lys His Leu Gln Gly Lys 
65                  70                  75                  80  


Leu Glu Gln Glu Ala Arg Val Leu Val Ser Ser Gly Gln Thr Glu Val 
                85                  90                  95      


Leu Glu Gln Leu Lys Ala Leu Gln Met Asp Ile Thr Ser Leu Tyr Asn 
            100                 105                 110         


Leu Lys Phe Gln Pro Pro Thr Leu Gly Pro Glu Pro Ala Ala Arg Thr 
        115                 120                 125             


Pro Glu Gly Ser Pro Val His Gly Ser Gly Pro Ser Lys Asp Ser Phe 
    130                 135                 140                 


Gly Glu Leu Ser Arg Ala Thr Ile Arg Leu Leu Glu Glu Leu Asp Arg 
145                 150                 155                 160 


Glu Arg Cys Phe Leu Leu Asn Glu Ile Glu Lys Glu Glu Lys Glu Lys 
                165                 170                 175     


Leu Trp Tyr Tyr Ser Gln Leu Gln Gly Leu Ser Lys Arg Leu Asp Glu 
            180                 185                 190         


Leu Pro His Val Glu Thr Gln Phe Ser Met Gln Met Asp Leu Ile Arg 
        195                 200                 205             


Gln Gln Leu Glu Phe Glu Ala Gln His Ile Arg Ser Leu Met Glu Glu 
    210                 215                 220                 


Arg Phe Gly Thr Ser Asp Glu Met Val Gln Arg Ala Gln Ile Arg Ala 
225                 230                 235                 240 


Ser Arg Leu Glu Gln Ile Asp Lys Glu Leu Leu Glu Ala Gln Asp Arg 
                245                 250                 255     


Val Gln Gln Thr Glu Pro Gln Ala Leu Leu Ala Val Lys Ser Val Pro 
            260                 265                 270         


Val Asp Glu Asp Pro Glu Thr Glu Val Pro Thr His Pro Glu Asp Gly 
        275                 280                 285             


Thr Pro Gln Pro Gly Asn Ser Lys Val Glu Val Val Phe Trp Leu Leu 
    290                 295                 300                 


Ser Met Leu Ala Thr Arg Asp Gln Glu Asp Thr Ala Arg Thr Leu Leu 
305                 310                 315                 320 


Ala Met Ser Ser Ser Pro Glu Ser Cys Val Ala Met Arg Arg Ser Gly 
                325                 330                 335     


Cys Leu Pro Leu Leu Leu Gln Ile Leu His Gly Thr Glu Ala Ala Ala 
            340                 345                 350         


Gly Gly Arg Ala Gly Ala Pro Gly Ala Pro Gly Ala Lys Asp Ala Arg 
        355                 360                 365             


Met Arg Ala Asn Ala Ala Leu His Asn Ile Val Phe Ser Gln Pro Asp 
    370                 375                 380                 


Gln Gly Leu Ala Arg Lys Glu Met Arg Val Leu His Val Leu Glu Gln 
385                 390                 395                 400 


Ile Arg Ala Tyr Cys Glu Thr Cys Trp Asp Trp Leu Gln Ala Arg Asp 
                405                 410                 415     


Gly Gly Pro Glu Gly Gly Gly Ala Gly Ser Ala Pro Ile Pro Ile Glu 
            420                 425                 430         


Pro Gln Ile Cys Gln Ala Thr Cys Ala Val Met Lys Leu Ser Phe Asp 
        435                 440                 445             


Glu Glu Tyr Arg Arg Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Val 
    450                 455                 460                 


Ala Glu Leu Leu Gln Val Asp Tyr Glu Met His Lys Met Thr Arg Asp 
465                 470                 475                 480 


Pro Leu Asn Leu Ala Leu Arg Arg Tyr Ala Gly Met Thr Leu Thr Asn 
                485                 490                 495     


Leu Thr Phe Gly Asp Val Ala Asn Lys Ala Thr Leu Cys Ala Arg Arg 
            500                 505                 510         


Gly Cys Met Glu Ala Ile Val Ala Gln Leu Ala Ser Asp Ser Glu Glu 
        515                 520                 525             


Leu His Gln Val Val Ser Ser Ile Leu Arg Asn Leu Ser Trp Arg Ala 
    530                 535                 540                 


Asp Ile Asn Ser Lys Lys Val Leu Arg Glu Ala Gly Ser Val Thr Ala 
545                 550                 555                 560 


Leu Val Gln Cys Val Leu Arg Ala Thr Lys Glu Ser Thr Leu Lys Ser 
                565                 570                 575     


Val Leu Ser Ala Leu Trp Asn Leu Ser Ala His Ser Thr Glu Asn Lys 
            580                 585                 590         


Ala Ala Ile Cys Gln Val Asp Gly Ala Leu Gly Phe Leu Val Ser Thr 
        595                 600                 605             


Leu Thr Tyr Lys Cys Gln Ser Asn Ser Leu Ala Ile Ile Glu Ser Gly 
    610                 615                 620                 


Gly Gly Ile Leu Arg Asn Val Ser Ser Leu Val Ala Thr Arg Glu Asp 
625                 630                 635                 640 


Tyr Arg Gln Val Leu Arg Asp His Asn Cys Leu Gln Thr Leu Leu Gln 
                645                 650                 655     


His Leu Thr Ser His Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr 
            660                 665                 670         


Leu Trp Asn Leu Ser Ala Arg Ser Ala Arg Asp Gln Glu Leu Leu Trp 
        675                 680                 685             


Asp Leu Gly Ala Val Gly Met Leu Arg Asn Leu Val His Ser Lys His 
    690                 695                 700                 


Lys Met Ile Ala Met Gly Ser Ala Ala Ala Leu Arg Asn Leu Leu Ala 
705                 710                 715                 720 


His Arg Pro Ala Lys His Gln Ala Ala Ala Thr Ala Val Ser Pro Gly 
                725                 730                 735     


Ser Cys Val Pro Ser Leu Tyr Val Arg Lys Gln Arg Ala Leu Glu Ala 
            740                 745                 750         


Glu Leu Asp Ala Arg His Leu Ala Gln Ala Leu Glu His Leu Glu Lys 
        755                 760                 765             


Gln Gly Pro Pro Ala Ala Glu Ala Ala Thr Lys Lys Pro Leu Pro Pro 
    770                 775                 780                 


Leu Arg His Leu Asp Gly Leu Ala Gln Asp Tyr Ala Ser Asp Ser Gly 
785                 790                 795                 800 


Cys Phe Asp Asp Asp Asp Ala Pro Ser Ser Leu Ala Ala Ala Ala Ala 
                805                 810                 815     


Thr Gly Glu Pro Ala Ser Pro Ala Ala Leu Ser Leu Phe Leu Gly Ser 
            820                 825                 830         


Pro Phe Leu Gln Gly Gln Ala Leu Ala Arg Thr Pro Pro Thr Arg Arg 
        835                 840                 845             


Gly Gly Lys Glu Ala Glu Lys Asp Thr Ser Gly Glu Ala Ala Val Ala 
    850                 855                 860                 


Ala Lys Ala Lys Ala Lys Leu Ala Leu Ala Val Ala Arg Ile Asp Gln 
865                 870                 875                 880 


Leu Val Glu Asp Ile Ser Ala Leu His Thr Ser Ser Asp Asp Ser Phe 
                885                 890                 895     


Ser Leu Ser Ser Gly Asp Pro Gly Gln Glu Ala Pro Arg Glu Gly Arg 
            900                 905                 910         


Ala Gln Ser Cys Ser Pro Cys Arg Gly Pro Glu Gly Gly Arg Arg Glu 
        915                 920                 925             


Ala Gly Ser Arg Ala His Pro Leu Leu Arg Leu Lys Ala Ala His Ala 
    930                 935                 940                 


Ser Leu Ser Asn Asp Ser Leu Asn Ser Gly Ser Ala Ser Asp Gly Tyr 
945                 950                 955                 960 


Cys Pro Arg Glu His Met Leu Pro Cys Pro Leu Ala Ala Leu Ala Ser 
                965                 970                 975     


Arg Arg Glu Asp Pro Arg Cys Gly Gln Pro Arg Pro Ser Arg Leu Asp 
            980                 985                 990         


Leu Asp Leu Pro Gly Cys Gln Ala  Glu Pro Pro Ala Arg  Glu Ala Thr 
        995                 1000                 1005             


Ser Ala  Asp Ala Arg Val Arg  Thr Ile Lys Leu Ser  Pro Thr Tyr 
    1010                 1015                 1020             


Gln His  Val Pro Leu Leu Glu  Gly Ala Ser Arg Ala  Gly Ala Glu 
    1025                 1030                 1035             


Pro Leu  Ala Gly Pro Gly Ile  Ser Pro Gly Ala Arg  Lys Gln Ala 
    1040                 1045                 1050             


Trp Leu  Pro Ala Asp His Leu  Ser Lys Val Pro Glu  Lys Leu Ala 
    1055                 1060                 1065             


Ala Ala  Pro Leu Ser Val Ala  Ser Lys Ala Leu Gln  Lys Leu Ala 
    1070                 1075                 1080             


Ala Gln  Glu Gly Pro Leu Ser  Leu Ser Arg Cys Ser  Ser Leu Ser 
    1085                 1090                 1095             


Ser Leu  Ser Ser Ala Gly Arg  Pro Gly Pro Ser Glu  Gly Gly Asp 
    1100                 1105                 1110             


Leu Asp  Asp Ser Asp Ser Ser  Leu Glu Gly Leu Glu  Glu Ala Gly 
    1115                 1120                 1125             


Pro Ser  Glu Ala Glu Leu Asp  Ser Thr Trp Arg Ala  Pro Gly Ala 
    1130                 1135                 1140             


Thr Ser  Leu Pro Val Ala Ile  Pro Ala Pro Arg Arg  Asn Arg Gly 
    1145                 1150                 1155             


Arg Gly  Leu Gly Val Glu Asp  Ala Thr Pro Ser Ser  Ser Ser Glu 
    1160                 1165                 1170             


Asn Tyr  Val Gln Glu Thr Pro  Leu Val Leu Ser Arg  Cys Ser Ser 
    1175                 1180                 1185             


Val Ser  Ser Leu Gly Ser Phe  Glu Ser Pro Ser Ile  Ala Ser Ser 
    1190                 1195                 1200             


Ile Pro  Ser Glu Pro Cys Ser  Gly Gln Gly Ser Gly  Thr Ile Ser 
    1205                 1210                 1215             


Pro Ser  Glu Leu Pro Asp Ser  Pro Gly Gln Thr Met  Pro Pro Ser 
    1220                 1225                 1230             


Arg Ser  Lys Thr Pro Pro Leu  Ala Pro Ala Pro Gln  Gly Pro Pro 
    1235                 1240                 1245             


Glu Ala  Thr Gln Phe Ser Leu  Gln Trp Glu Ser Tyr  Val Lys Arg 
    1250                 1255                 1260             


Phe Leu  Asp Ile Ala Asp Cys  Arg Glu Arg Cys Arg  Leu Pro Ser 
    1265                 1270                 1275             


Glu Leu  Asp Ala Gly Ser Val  Arg Phe Thr Val Glu  Lys Pro Asp 
    1280                 1285                 1290             


Glu Asn  Phe Ser Cys Ala Ser  Ser Leu Ser Ala Leu  Ala Leu His 
    1295                 1300                 1305             


Glu His  Tyr Val Gln Gln Asp  Val Glu Leu Arg Leu  Leu Pro Ser 
    1310                 1315                 1320             


Ala Cys  Pro Glu Arg Gly Gly  Gly Ala Gly Gly Ala  Gly Leu His 
    1325                 1330                 1335             


Phe Ala  Gly His Arg Arg Arg  Glu Glu Gly Pro Ala  Pro Thr Gly 
    1340                 1345                 1350             


Ser Arg  Pro Arg Gly Ala Ala  Asp Gln Glu Leu Glu  Leu Leu Arg 
    1355                 1360                 1365             


Glu Cys  Leu Gly Ala Ala Val  Pro Ala Arg Leu Arg  Lys Val Ala 
    1370                 1375                 1380             


Ser Ala  Leu Val Pro Gly Arg  Arg Ala Leu Pro Val  Pro Val Tyr 
    1385                 1390                 1395             


Met Leu  Val Pro Ala Pro Ala  Pro Ala Gln Glu Asp  Asp Ser Cys 
    1400                 1405                 1410             


Thr Asp  Ser Ala Glu Gly Thr  Pro Val Asn Phe Ser  Ser Ala Ala 
    1415                 1420                 1425             


Ser Leu  Ser Asp Glu Thr Leu  Gln Gly Pro Pro Arg  Asp Gln Pro 
    1430                 1435                 1440             


Gly Gly  Pro Ala Gly Arg Gln  Arg Pro Thr Gly Arg  Pro Thr Ser 
    1445                 1450                 1455             


Ala Arg  Gln Ala Met Gly His  Arg His Lys Ala Gly  Gly Ala Gly 
    1460                 1465                 1470             


Arg Ser  Ala Glu Gln Ser Arg  Gly Ala Gly Lys Asn  Arg Ala Gly 
    1475                 1480                 1485             


Leu Glu  Leu Pro Leu Gly Arg  Pro Pro Ser Ala Pro  Ala Asp Lys 
    1490                 1495                 1500             


Asp Gly  Ser Lys Pro Gly Arg  Thr Arg Gly Asp Gly  Ala Leu Gln 
    1505                 1510                 1515             


Ser Leu  Cys Leu Thr Thr Pro  Thr Glu Glu Ala Val  Tyr Cys Phe 
    1520                 1525                 1530             


Tyr Gly  Asn Asp Ser Asp Glu  Glu Pro Pro Ala Ala  Ala Pro Thr 
    1535                 1540                 1545             


Pro Thr  His Arg Arg Thr Ser  Ala Ile Pro Arg Ala  Phe Thr Arg 
    1550                 1555                 1560             


Glu Arg  Pro Gln Gly Arg Lys  Glu Ala Pro Ala Pro  Ser Lys Ala 
    1565                 1570                 1575             


Ala Pro  Ala Ala Pro Pro Pro  Ala Arg Thr Gln Pro  Ser Leu Ile 
    1580                 1585                 1590             


Ala Asp  Glu Thr Pro Pro Cys  Tyr Ser Leu Ser Ser  Ser Ala Ser 
    1595                 1600                 1605             


Ser Leu  Ser Glu Pro Glu Pro  Ser Glu Pro Pro Ala  Val His Pro 
    1610                 1615                 1620             


Arg Gly  Arg Glu Pro Ala Val  Thr Lys Asp Pro Gly  Pro Gly Gly 
    1625                 1630                 1635             


Gly Arg  Asp Ser Ser Pro Ser  Pro Arg Ala Ala Glu  Glu Leu Leu 
    1640                 1645                 1650             


Gln Arg  Cys Ile Ser Ser Ala  Leu Pro Arg Arg Arg  Pro Pro Val 
    1655                 1660                 1665             


Ser Gly  Leu Arg Arg Arg Lys  Pro Arg Ala Thr Arg  Leu Asp Glu 
    1670                 1675                 1680             


Arg Pro  Ala Glu Gly Ser Arg  Glu Arg Gly Glu Glu  Ala Ala Gly 
    1685                 1690                 1695             


Ser Asp  Arg Ala Ser Asp Leu  Asp Ser Val Glu Trp  Arg Ala Ile 
    1700                 1705                 1710             


Gln Glu  Gly Ala Asn Ser Ile  Val Thr Trp Leu His  Gln Ala Ala 
    1715                 1720                 1725             


Ala Ala  Thr Arg Glu Ala Ser  Ser Glu Ser Asp Ser  Ile Leu Ser 
    1730                 1735                 1740             


Phe Val  Ser Gly Leu Ser Val  Gly Ser Thr Leu Gln  Pro Pro Lys 
    1745                 1750                 1755             


His Arg  Lys Gly Arg Gln Ala  Glu Gly Glu Met Gly  Ser Ala Arg 
    1760                 1765                 1770             


Arg Pro  Glu Lys Arg Gly Ala  Ala Ser Val Lys Thr  Ser Gly Ser 
    1775                 1780                 1785             


Pro Arg  Ser Pro Ala Gly Pro  Glu Lys Pro Arg Gly  Thr Gln Lys 
    1790                 1795                 1800             


Thr Thr  Pro Gly Val Pro Ala  Val Leu Arg Gly Arg  Thr Val Ile 
    1805                 1810                 1815             


Tyr Val  Pro Ser Pro Ala Pro  Arg Ala Gln Pro Lys  Gly Thr Pro 
    1820                 1825                 1830             


Gly Pro  Arg Ala Thr Pro Arg  Lys Val Ala Pro Pro  Cys Leu Ala 
    1835                 1840                 1845             


Gln Pro  Ala Ala Pro Ala Lys  Val Pro Ser Pro Gly  Gln Gln Arg 
    1850                 1855                 1860             


Ser Arg  Ser Leu His Arg Pro  Ala Lys Thr Ser Glu  Leu Ala Thr 
    1865                 1870                 1875             


Leu Ser  Gln Pro Pro Arg Ser  Ala Thr Pro Pro Ala  Arg Leu Ala 
    1880                 1885                 1890             


Lys Thr  Pro Ser Ser Ser Ser  Ser Gln Thr Ser Pro  Ala Ser Gln 
    1895                 1900                 1905             


Pro Leu  Pro Arg Lys Arg Pro  Pro Val Thr Gln Ala  Ala Gly Ala 
    1910                 1915                 1920             


Leu Pro  Gly Pro Gly Ala Ser  Pro Val Pro Lys Thr  Pro Ala Arg 
    1925                 1930                 1935             


Thr Leu  Leu Ala Lys Gln His  Lys Thr Gln Arg Ser  Pro Val Arg 
    1940                 1945                 1950             


Ile Pro  Phe Met Gln Arg Pro  Ala Arg Arg Gly Pro  Pro Pro Leu 
    1955                 1960                 1965             


Ala Arg  Ala Val Pro Glu Pro  Gly Pro Arg Gly Arg  Ala Gly Thr 
    1970                 1975                 1980             


Glu Ala  Gly Pro Gly Ala Arg  Gly Gly Arg Leu Gly  Leu Val Arg 
    1985                 1990                 1995             


Val Ala  Ser Ala Leu Ser Ser  Gly Ser Glu Ser Ser  Asp Arg Ser 
    2000                 2005                 2010             


Gly Phe  Arg Arg Gln Leu Thr  Phe Ile Lys Glu Ser  Pro Gly Leu 
    2015                 2020                 2025             


Arg Arg  Arg Arg Ser Glu Leu  Ser Ser Ala Glu Ser  Ala Ala Ser 
    2030                 2035                 2040             


Ala Pro  Gln Gly Ala Ser Pro  Arg Arg Gly Arg Pro  Ala Leu Pro 
    2045                 2050                 2055             


Ala Val  Phe Leu Cys Ser Ser  Arg Cys Glu Glu Leu  Arg Ala Ala 
    2060                 2065                 2070             


Pro Arg  Gln Gly Pro Ala Pro  Ala Arg Gln Arg Pro  Pro Ala Ala 
    2075                 2080                 2085             


Arg Pro  Ser Pro Gly Glu Arg  Pro Ala Arg Arg Thr  Thr Ser Glu 
    2090                 2095                 2100             


Ser Pro  Ser Arg Leu Pro Val  Arg Ala Pro Ala Ala  Arg Pro Glu 
    2105                 2110                 2115             


Thr Val  Lys Arg Tyr Ala Ser  Leu Pro His Ile Ser  Val Ala Arg 
    2120                 2125                 2130             


Arg Pro  Asp Gly Ala Val Pro  Ala Ala Pro Ala Ser  Ala Asp Ala 
    2135                 2140                 2145             


Ala Arg  Arg Ser Ser Asp Gly  Glu Pro Arg Pro Leu  Pro Arg Val 
    2150                 2155                 2160             


Ala Ala  Pro Gly Thr Thr Trp  Arg Arg Ile Arg Asp  Glu Asp Val 
    2165                 2170                 2175             


Pro His  Ile Leu Arg Ser Thr  Leu Pro Ala Thr Ala  Leu Pro Leu 
    2180                 2185                 2190             


Arg Gly  Ser Thr Pro Glu Asp  Ala Pro Ala Gly Pro  Pro Pro Arg 
    2195                 2200                 2205             


Lys Thr  Ser Asp Ala Val Val  Gln Thr Glu Glu Val  Ala Ala Pro 
    2210                 2215                 2220             


Lys Thr  Asn Ser Ser Thr Ser  Pro Ser Leu Glu Thr  Arg Glu Pro 
    2225                 2230                 2235             


Pro Gly  Ala Pro Ala Gly Gly  Gln Leu Ser Leu Leu  Gly Ser Asp 
    2240                 2245                 2250             


Val Asp  Gly Pro Ser Leu Ala  Lys Ala Pro Ile Ser  Ala Pro Phe 
    2255                 2260                 2265             


Val His  Glu Gly Leu Gly Val  Ala Val Gly Gly Phe  Pro Ala Ser 
    2270                 2275                 2280             


Arg His  Gly Ser Pro Ser Arg  Ser Ala Arg Val Pro  Pro Phe Asn 
    2285                 2290                 2295             


Tyr Val  Pro Ser Pro Met Val  Val Ala Ala Thr Thr  Asp Ser Ala 
    2300                 2305                 2310             


Ala Glu  Lys Ala Pro Ala Thr  Ala Ser Ala Thr Leu  Leu Glu 
    2315                 2320                 2325         


<210>  624
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APCDD1__Homo_sapiens__NP_694545

<400>  624

Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser 
            20                  25                  30          


Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys 
        35                  40                  45              


Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg 
    50                  55                  60                  


Ile Thr Val Gln Met Pro Pro Thr Ile Glu Gly His Trp Val Ser Thr 
65                  70                  75                  80  


Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Thr Arg Ser Tyr Arg 
                85                  90                  95      


Phe Tyr His Asn Asn Thr Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser 
            100                 105                 110         


Asn Arg Cys Thr Asn Pro Thr Tyr Thr Leu Ile Ile Arg Gly Lys Ile 
        115                 120                 125             


Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Thr Glu Ala Asp 
    130                 135                 140                 


Tyr Gln Leu His Asn Val Gln Val Ile Cys His Thr Glu Ala Val Ala 
145                 150                 155                 160 


Glu Lys Leu Gly Gln Gln Val Asn Arg Thr Cys Pro Gly Phe Leu Ala 
                165                 170                 175     


Asp Gly Gly Pro Trp Val Gln Asp Val Ala Tyr Asp Leu Trp Arg Glu 
            180                 185                 190         


Glu Asn Gly Cys Glu Cys Thr Lys Ala Val Asn Phe Ala Met His Glu 
        195                 200                 205             


Leu Gln Leu Ile Arg Val Glu Lys Gln Tyr Leu His His Asn Leu Asp 
    210                 215                 220                 


His Leu Val Glu Glu Leu Phe Leu Gly Asp Ile His Thr Asp Ala Thr 
225                 230                 235                 240 


Gln Arg Met Phe Tyr Arg Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn 
                245                 250                 255     


Ala Lys Asn His Asp His Ala Cys Ile Ala Cys Arg Ile Ile Tyr Arg 
            260                 265                 270         


Ser Asp Glu His His Pro Pro Ile Leu Pro Pro Lys Ala Asp Leu Thr 
        275                 280                 285             


Ile Gly Leu His Gly Glu Trp Val Ser Gln Arg Cys Glu Val Arg Pro 
    290                 295                 300                 


Glu Val Leu Phe Leu Thr Arg His Phe Ile Phe His Asp Asn Asn Asn 
305                 310                 315                 320 


Thr Trp Glu Gly His Tyr Tyr His Tyr Ser Asp Pro Val Cys Lys His 
                325                 330                 335     


Pro Thr Phe Ser Ile Tyr Ala Arg Gly Arg Tyr Ser Arg Gly Val Leu 
            340                 345                 350         


Ser Ser Arg Val Met Gly Gly Thr Glu Phe Val Phe Lys Val Asn His 
        355                 360                 365             


Met Lys Val Thr Pro Met Asp Ala Ala Thr Ala Ser Leu Leu Asn Val 
    370                 375                 380                 


Phe Asn Gly Asn Glu Cys Gly Ala Glu Gly Ser Trp Gln Val Gly Ile 
385                 390                 395                 400 


Gln Gln Asp Val Thr His Thr Asn Gly Cys Val Ala Leu Gly Ile Lys 
                405                 410                 415     


Leu Pro His Thr Glu Tyr Glu Ile Phe Lys Met Glu Gln Asp Ala Arg 
            420                 425                 430         


Gly Arg Tyr Leu Leu Phe Asn Gly Gln Arg Pro Ser Asp Gly Ser Ser 
        435                 440                 445             


Pro Asp Arg Pro Glu Lys Arg Ala Thr Ser Tyr Gln Met Pro Leu Val 
    450                 455                 460                 


Gln Cys Ala Ser Ser Ser Pro Arg Ala Glu Asp Leu Ala Glu Asp Ser 
465                 470                 475                 480 


Gly Ser Ser Leu Tyr Gly Arg Ala Pro Gly Arg His Thr Trp Ser Leu 
                485                 490                 495     


Leu Leu Ala Ala Leu Ala Cys Leu Val Pro Leu Leu His Trp Asn Ile 
            500                 505                 510         


Arg Arg 
        


<210>  625
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APCDD1L__Homo_sapiens__NP_001291716

<400>  625

Met Ala Glu Asn Ser Gly Pro Gly Val Arg Pro Pro Gly Trp Glu Ala 
1               5                   10                  15      


Gln Ile Asn Ile Ile Ser Thr Arg Leu Ala Leu Ala His Thr Ala Pro 
            20                  25                  30          


Ala Ala Gly Glu Ala Gly Gly Ser Cys Leu Arg Trp Glu Pro His Cys 
        35                  40                  45              


Gln Gln Pro Leu Pro Asp Arg Val Pro Ser Thr Ala Ile Leu Pro Pro 
    50                  55                  60                  


Arg Leu Asn Gly Pro Trp Ile Ser Thr Gly Cys Glu Val Arg Pro Gly 
65                  70                  75                  80  


Pro Glu Phe Leu Thr Arg Ala Tyr Thr Phe Tyr Pro Ser Arg Leu Phe 
                85                  90                  95      


Arg Ala His Gln Phe Tyr Tyr Glu Asp Pro Phe Cys Gly Glu Pro Ala 
            100                 105                 110         


His Ser Leu Leu Val Lys Gly Lys Val Arg Leu Arg Arg Ala Ser Trp 
        115                 120                 125             


Val Thr Arg Gly Ala Thr Glu Ala Asp Tyr His Leu His Lys Val Gly 
    130                 135                 140                 


Ile Val Phe His Ser Arg Arg Ala Leu Val Asp Val Thr Gly Arg Leu 
145                 150                 155                 160 


Asn Gln Thr Arg Ala Gly Arg Asp Cys Ala Arg Arg Leu Pro Pro Ala 
                165                 170                 175     


Arg Ala Trp Leu Pro Gly Ala Leu Tyr Glu Leu Arg Ser Ala Arg Ala 
            180                 185                 190         


Gln Gly Asp Cys Leu Glu Ala Leu Gly Leu Thr Met His Glu Leu Ser 
        195                 200                 205             


Leu Val Arg Val Gln Arg Arg Leu Gln Pro Gln Pro Arg Ala Ser Pro 
    210                 215                 220                 


Arg Leu Val Glu Glu Leu Tyr Leu Gly Asp Ile His Thr Asp Pro Ala 
225                 230                 235                 240 


Glu Arg Arg His Tyr Arg Pro Thr Gly Tyr Gln Arg Pro Leu Gln Ser 
                245                 250                 255     


Ala Leu His His Val Gln Pro Cys Pro Ala Cys Gly Leu Ile Ala Arg 
            260                 265                 270         


Ser Asp Val His His Pro Pro Val Leu Pro Pro Pro Leu Ala Leu Pro 
        275                 280                 285             


Leu His Leu Gly Gly Trp Trp Val Ser Ser Gly Cys Glu Val Arg Pro 
    290                 295                 300                 


Ala Val Leu Phe Leu Thr Arg Leu Phe Thr Phe His Gly His Ser Arg 
305                 310                 315                 320 


Ser Trp Glu Gly Tyr Tyr His His Phe Ser Asp Pro Ala Cys Arg Gln 
                325                 330                 335     


Pro Thr Phe Thr Val Tyr Ala Ala Gly Arg Tyr Thr Arg Gly Thr Pro 
            340                 345                 350         


Ser Thr Arg Val Arg Gly Gly Thr Glu Leu Val Phe Glu Val Thr Arg 
        355                 360                 365             


Ala His Val Thr Pro Met Asp Gln Val Thr Thr Ala Met Leu Asn Phe 
    370                 375                 380                 


Ser Glu Pro Ser Ser Cys Gly Gly Ala Gly Ala Trp Ser Met Gly Thr 
385                 390                 395                 400 


Glu Arg Asp Val Thr Ala Thr Asn Gly Cys Leu Pro Leu Gly Ile Arg 
                405                 410                 415     


Leu Pro His Val Glu Tyr Glu Leu Phe Lys Met Glu Gln Asp Pro Leu 
            420                 425                 430         


Gly Gln Ser Leu Leu Phe Ile Gly Gln Arg Pro Thr Asp Gly Ser Ser 
        435                 440                 445             


Pro Asp Thr Pro Glu Lys Arg Pro Thr Ser Tyr Gln Ala Pro Leu Val 
    450                 455                 460                 


Leu Cys His Gly Glu Ala Pro Asp Phe Ser Arg Pro Pro Gln His Arg 
465                 470                 475                 480 


Pro Ser Leu Gln Lys His Pro Ser Thr Gly Gly Leu His Ile Ala Pro 
                485                 490                 495     


Phe Pro Leu Leu Pro Leu Val Leu Gly Leu Ala Phe Leu His Trp Leu 
            500                 505                 510         


<210>  626
<211>  2843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APC__Homo_sapiens__NP_001120982

<400>  626

Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
1               5                   10                  15      


Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
            20                  25                  30          


His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu 
        35                  40                  45              


Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 
    50                  55                  60                  


Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 
65                  70                  75                  80  


Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 
                85                  90                  95      


Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 
            100                 105                 110         


Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 
        115                 120                 125             


Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 
    130                 135                 140                 


Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 
145                 150                 155                 160 


Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu 
                165                 170                 175     


Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu 
            180                 185                 190         


Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln 
        195                 200                 205             


Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 
    210                 215                 220                 


Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr 
225                 230                 235                 240 


Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp 
                245                 250                 255     


Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 
            260                 265                 270         


Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr 
        275                 280                 285             


Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu 
    290                 295                 300                 


Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser 
305                 310                 315                 320 


Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala 
                325                 330                 335     


Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys 
            340                 345                 350         


Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val 
        355                 360                 365             


Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser 
    370                 375                 380                 


Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly 
385                 390                 395                 400 


Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr 
                405                 410                 415     


Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp 
            420                 425                 430         


Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro 
        435                 440                 445             


Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His 
    450                 455                 460                 


Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln 
465                 470                 475                 480 


Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr 
                485                 490                 495     


Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp 
            500                 505                 510         


Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala 
        515                 520                 525             


Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile 
    530                 535                 540                 


Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys 
545                 550                 555                 560 


Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala 
                565                 570                 575     


Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu 
            580                 585                 590         


Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala 
        595                 600                 605             


Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser 
    610                 615                 620                 


Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg 
625                 630                 635                 640 


Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu 
                645                 650                 655     


Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His 
            660                 665                 670         


Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser 
        675                 680                 685             


Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val 
    690                 695                 700                 


Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met 
705                 710                 715                 720 


Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys 
                725                 730                 735     


Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu 
            740                 745                 750         


His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His 
        755                 760                 765             


Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser 
    770                 775                 780                 


His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val 
785                 790                 795                 800 


Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr 
                805                 810                 815     


Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro 
            820                 825                 830         


Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys 
        835                 840                 845             


Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His 
    850                 855                 860                 


Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile 
865                 870                 875                 880 


Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala 
                885                 890                 895     


Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu 
            900                 905                 910         


His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala 
        915                 920                 925             


His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn 
    930                 935                 940                 


Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser 
945                 950                 955                 960 


Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg 
                965                 970                 975     


Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser 
            980                 985                 990         


Lys Phe Cys Ser Tyr Gly Gln Tyr  Pro Ala Asp Leu Ala  His Lys Ile 
        995                 1000                 1005             


His Ser  Ala Asn His Met Asp  Asp Asn Asp Gly Glu  Leu Asp Thr 
    1010                 1015                 1020             


Pro Ile  Asn Tyr Ser Leu Lys  Tyr Ser Asp Glu Gln  Leu Asn Ser 
    1025                 1030                 1035             


Gly Arg  Gln Ser Pro Ser Gln  Asn Glu Arg Trp Ala  Arg Pro Lys 
    1040                 1045                 1050             


His Ile  Ile Glu Asp Glu Ile  Lys Gln Ser Glu Gln  Arg Gln Ser 
    1055                 1060                 1065             


Arg Asn  Gln Ser Thr Thr Tyr  Pro Val Tyr Thr Glu  Ser Thr Asp 
    1070                 1075                 1080             


Asp Lys  His Leu Lys Phe Gln  Pro His Phe Gly Gln  Gln Glu Cys 
    1085                 1090                 1095             


Val Ser  Pro Tyr Arg Ser Arg  Gly Ala Asn Gly Ser  Glu Thr Asn 
    1100                 1105                 1110             


Arg Val  Gly Ser Asn His Gly  Ile Asn Gln Asn Val  Ser Gln Ser 
    1115                 1120                 1125             


Leu Cys  Gln Glu Asp Asp Tyr  Glu Asp Asp Lys Pro  Thr Asn Tyr 
    1130                 1135                 1140             


Ser Glu  Arg Tyr Ser Glu Glu  Glu Gln His Glu Glu  Glu Glu Arg 
    1145                 1150                 1155             


Pro Thr  Asn Tyr Ser Ile Lys  Tyr Asn Glu Glu Lys  Arg His Val 
    1160                 1165                 1170             


Asp Gln  Pro Ile Asp Tyr Ser  Leu Lys Tyr Ala Thr  Asp Ile Pro 
    1175                 1180                 1185             


Ser Ser  Gln Lys Gln Ser Phe  Ser Phe Ser Lys Ser  Ser Ser Gly 
    1190                 1195                 1200             


Gln Ser  Ser Lys Thr Glu His  Met Ser Ser Ser Ser  Glu Asn Thr 
    1205                 1210                 1215             


Ser Thr  Pro Ser Ser Asn Ala  Lys Arg Gln Asn Gln  Leu His Pro 
    1220                 1225                 1230             


Ser Ser  Ala Gln Ser Arg Ser  Gly Gln Pro Gln Lys  Ala Ala Thr 
    1235                 1240                 1245             


Cys Lys  Val Ser Ser Ile Asn  Gln Glu Thr Ile Gln  Thr Tyr Cys 
    1250                 1255                 1260             


Val Glu  Asp Thr Pro Ile Cys  Phe Ser Arg Cys Ser  Ser Leu Ser 
    1265                 1270                 1275             


Ser Leu  Ser Ser Ala Glu Asp  Glu Ile Gly Cys Asn  Gln Thr Thr 
    1280                 1285                 1290             


Gln Glu  Ala Asp Ser Ala Asn  Thr Leu Gln Ile Ala  Glu Ile Lys 
    1295                 1300                 1305             


Glu Lys  Ile Gly Thr Arg Ser  Ala Glu Asp Pro Val  Ser Glu Val 
    1310                 1315                 1320             


Pro Ala  Val Ser Gln His Pro  Arg Thr Lys Ser Ser  Arg Leu Gln 
    1325                 1330                 1335             


Gly Ser  Ser Leu Ser Ser Glu  Ser Ala Arg His Lys  Ala Val Glu 
    1340                 1345                 1350             


Phe Ser  Ser Gly Ala Lys Ser  Pro Ser Lys Ser Gly  Ala Gln Thr 
    1355                 1360                 1365             


Pro Lys  Ser Pro Pro Glu His  Tyr Val Gln Glu Thr  Pro Leu Met 
    1370                 1375                 1380             


Phe Ser  Arg Cys Thr Ser Val  Ser Ser Leu Asp Ser  Phe Glu Ser 
    1385                 1390                 1395             


Arg Ser  Ile Ala Ser Ser Val  Gln Ser Glu Pro Cys  Ser Gly Met 
    1400                 1405                 1410             


Val Ser  Gly Ile Ile Ser Pro  Ser Asp Leu Pro Asp  Ser Pro Gly 
    1415                 1420                 1425             


Gln Thr  Met Pro Pro Ser Arg  Ser Lys Thr Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gln Thr  Ala Gln Thr Lys Arg  Glu Val Pro Lys Asn  Lys Ala Pro 
    1445                 1450                 1455             


Thr Ala  Glu Lys Arg Glu Ser  Gly Pro Lys Gln Ala  Ala Val Asn 
    1460                 1465                 1470             


Ala Ala  Val Gln Arg Val Gln  Val Leu Pro Asp Ala  Asp Thr Leu 
    1475                 1480                 1485             


Leu His  Phe Ala Thr Glu Ser  Thr Pro Asp Gly Phe  Ser Cys Ser 
    1490                 1495                 1500             


Ser Ser  Leu Ser Ala Leu Ser  Leu Asp Glu Pro Phe  Ile Gln Lys 
    1505                 1510                 1515             


Asp Val  Glu Leu Arg Ile Met  Pro Pro Val Gln Glu  Asn Asp Asn 
    1520                 1525                 1530             


Gly Asn  Glu Thr Glu Ser Glu  Gln Pro Lys Glu Ser  Asn Glu Asn 
    1535                 1540                 1545             


Gln Glu  Lys Glu Ala Glu Lys  Thr Ile Asp Ser Glu  Lys Asp Leu 
    1550                 1555                 1560             


Leu Asp  Asp Ser Asp Asp Asp  Asp Ile Glu Ile Leu  Glu Glu Cys 
    1565                 1570                 1575             


Ile Ile  Ser Ala Met Pro Thr  Lys Ser Ser Arg Lys  Ala Lys Lys 
    1580                 1585                 1590             


Pro Ala  Gln Thr Ala Ser Lys  Leu Pro Pro Pro Val  Ala Arg Lys 
    1595                 1600                 1605             


Pro Ser  Gln Leu Pro Val Tyr  Lys Leu Leu Pro Ser  Gln Asn Arg 
    1610                 1615                 1620             


Leu Gln  Pro Gln Lys His Val  Ser Phe Thr Pro Gly  Asp Asp Met 
    1625                 1630                 1635             


Pro Arg  Val Tyr Cys Val Glu  Gly Thr Pro Ile Asn  Phe Ser Thr 
    1640                 1645                 1650             


Ala Thr  Ser Leu Ser Asp Leu  Thr Ile Glu Ser Pro  Pro Asn Glu 
    1655                 1660                 1665             


Leu Ala  Ala Gly Glu Gly Val  Arg Gly Gly Ala Gln  Ser Gly Glu 
    1670                 1675                 1680             


Phe Glu  Lys Arg Asp Thr Ile  Pro Thr Glu Gly Arg  Ser Thr Asp 
    1685                 1690                 1695             


Glu Ala  Gln Gly Gly Lys Thr  Ser Ser Val Thr Ile  Pro Glu Leu 
    1700                 1705                 1710             


Asp Asp  Asn Lys Ala Glu Glu  Gly Asp Ile Leu Ala  Glu Cys Ile 
    1715                 1720                 1725             


Asn Ser  Ala Met Pro Lys Gly  Lys Ser His Lys Pro  Phe Arg Val 
    1730                 1735                 1740             


Lys Lys  Ile Met Asp Gln Val  Gln Gln Ala Ser Ala  Ser Ser Ser 
    1745                 1750                 1755             


Ala Pro  Asn Lys Asn Gln Leu  Asp Gly Lys Lys Lys  Lys Pro Thr 
    1760                 1765                 1770             


Ser Pro  Val Lys Pro Ile Pro  Gln Asn Thr Glu Tyr  Arg Thr Arg 
    1775                 1780                 1785             


Val Arg  Lys Asn Ala Asp Ser  Lys Asn Asn Leu Asn  Ala Glu Arg 
    1790                 1795                 1800             


Val Phe  Ser Asp Asn Lys Asp  Ser Lys Lys Gln Asn  Leu Lys Asn 
    1805                 1810                 1815             


Asn Ser  Lys Val Phe Asn Asp  Lys Leu Pro Asn Asn  Glu Asp Arg 
    1820                 1825                 1830             


Val Arg  Gly Ser Phe Ala Phe  Asp Ser Pro His His  Tyr Thr Pro 
    1835                 1840                 1845             


Ile Glu  Gly Thr Pro Tyr Cys  Phe Ser Arg Asn Asp  Ser Leu Ser 
    1850                 1855                 1860             


Ser Leu  Asp Phe Asp Asp Asp  Asp Val Asp Leu Ser  Arg Glu Lys 
    1865                 1870                 1875             


Ala Glu  Leu Arg Lys Ala Lys  Glu Asn Lys Glu Ser  Glu Ala Lys 
    1880                 1885                 1890             


Val Thr  Ser His Thr Glu Leu  Thr Ser Asn Gln Gln  Ser Ala Asn 
    1895                 1900                 1905             


Lys Thr  Gln Ala Ile Ala Lys  Gln Pro Ile Asn Arg  Gly Gln Pro 
    1910                 1915                 1920             


Lys Pro  Ile Leu Gln Lys Gln  Ser Thr Phe Pro Gln  Ser Ser Lys 
    1925                 1930                 1935             


Asp Ile  Pro Asp Arg Gly Ala  Ala Thr Asp Glu Lys  Leu Gln Asn 
    1940                 1945                 1950             


Phe Ala  Ile Glu Asn Thr Pro  Val Cys Phe Ser His  Asn Ser Ser 
    1955                 1960                 1965             


Leu Ser  Ser Leu Ser Asp Ile  Asp Gln Glu Asn Asn  Asn Lys Glu 
    1970                 1975                 1980             


Asn Glu  Pro Ile Lys Glu Thr  Glu Pro Pro Asp Ser  Gln Gly Glu 
    1985                 1990                 1995             


Pro Ser  Lys Pro Gln Ala Ser  Gly Tyr Ala Pro Lys  Ser Phe His 
    2000                 2005                 2010             


Val Glu  Asp Thr Pro Val Cys  Phe Ser Arg Asn Ser  Ser Leu Ser 
    2015                 2020                 2025             


Ser Leu  Ser Ile Asp Ser Glu  Asp Asp Leu Leu Gln  Glu Cys Ile 
    2030                 2035                 2040             


Ser Ser  Ala Met Pro Lys Lys  Lys Lys Pro Ser Arg  Leu Lys Gly 
    2045                 2050                 2055             


Asp Asn  Glu Lys His Ser Pro  Arg Asn Met Gly Gly  Ile Leu Gly 
    2060                 2065                 2070             


Glu Asp  Leu Thr Leu Asp Leu  Lys Asp Ile Gln Arg  Pro Asp Ser 
    2075                 2080                 2085             


Glu His  Gly Leu Ser Pro Asp  Ser Glu Asn Phe Asp  Trp Lys Ala 
    2090                 2095                 2100             


Ile Gln  Glu Gly Ala Asn Ser  Ile Val Ser Ser Leu  His Gln Ala 
    2105                 2110                 2115             


Ala Ala  Ala Ala Cys Leu Ser  Arg Gln Ala Ser Ser  Asp Ser Asp 
    2120                 2125                 2130             


Ser Ile  Leu Ser Leu Lys Ser  Gly Ile Ser Leu Gly  Ser Pro Phe 
    2135                 2140                 2145             


His Leu  Thr Pro Asp Gln Glu  Glu Lys Pro Phe Thr  Ser Asn Lys 
    2150                 2155                 2160             


Gly Pro  Arg Ile Leu Lys Pro  Gly Glu Lys Ser Thr  Leu Glu Thr 
    2165                 2170                 2175             


Lys Lys  Ile Glu Ser Glu Ser  Lys Gly Ile Lys Gly  Gly Lys Lys 
    2180                 2185                 2190             


Val Tyr  Lys Ser Leu Ile Thr  Gly Lys Val Arg Ser  Asn Ser Glu 
    2195                 2200                 2205             


Ile Ser  Gly Gln Met Lys Gln  Pro Leu Gln Ala Asn  Met Pro Ser 
    2210                 2215                 2220             


Ile Ser  Arg Gly Arg Thr Met  Ile His Ile Pro Gly  Val Arg Asn 
    2225                 2230                 2235             


Ser Ser  Ser Ser Thr Ser Pro  Val Ser Lys Lys Gly  Pro Pro Leu 
    2240                 2245                 2250             


Lys Thr  Pro Ala Ser Lys Ser  Pro Ser Glu Gly Gln  Thr Ala Thr 
    2255                 2260                 2265             


Thr Ser  Pro Arg Gly Ala Lys  Pro Ser Val Lys Ser  Glu Leu Ser 
    2270                 2275                 2280             


Pro Val  Ala Arg Gln Thr Ser  Gln Ile Gly Gly Ser  Ser Lys Ala 
    2285                 2290                 2295             


Pro Ser  Arg Ser Gly Ser Arg  Asp Ser Thr Pro Ser  Arg Pro Ala 
    2300                 2305                 2310             


Gln Gln  Pro Leu Ser Arg Pro  Ile Gln Ser Pro Gly  Arg Asn Ser 
    2315                 2320                 2325             


Ile Ser  Pro Gly Arg Asn Gly  Ile Ser Pro Pro Asn  Lys Leu Ser 
    2330                 2335                 2340             


Gln Leu  Pro Arg Thr Ser Ser  Pro Ser Thr Ala Ser  Thr Lys Ser 
    2345                 2350                 2355             


Ser Gly  Ser Gly Lys Met Ser  Tyr Thr Ser Pro Gly  Arg Gln Met 
    2360                 2365                 2370             


Ser Gln  Gln Asn Leu Thr Lys  Gln Thr Gly Leu Ser  Lys Asn Ala 
    2375                 2380                 2385             


Ser Ser  Ile Pro Arg Ser Glu  Ser Ala Ser Lys Gly  Leu Asn Gln 
    2390                 2395                 2400             


Met Asn  Asn Gly Asn Gly Ala  Asn Lys Lys Val Glu  Leu Ser Arg 
    2405                 2410                 2415             


Met Ser  Ser Thr Lys Ser Ser  Gly Ser Glu Ser Asp  Arg Ser Glu 
    2420                 2425                 2430             


Arg Pro  Val Leu Val Arg Gln  Ser Thr Phe Ile Lys  Glu Ala Pro 
    2435                 2440                 2445             


Ser Pro  Thr Leu Arg Arg Lys  Leu Glu Glu Ser Ala  Ser Phe Glu 
    2450                 2455                 2460             


Ser Leu  Ser Pro Ser Ser Arg  Pro Ala Ser Pro Thr  Arg Ser Gln 
    2465                 2470                 2475             


Ala Gln  Thr Pro Val Leu Ser  Pro Ser Leu Pro Asp  Met Ser Leu 
    2480                 2485                 2490             


Ser Thr  His Ser Ser Val Gln  Ala Gly Gly Trp Arg  Lys Leu Pro 
    2495                 2500                 2505             


Pro Asn  Leu Ser Pro Thr Ile  Glu Tyr Asn Asp Gly  Arg Pro Ala 
    2510                 2515                 2520             


Lys Arg  His Asp Ile Ala Arg  Ser His Ser Glu Ser  Pro Ser Arg 
    2525                 2530                 2535             


Leu Pro  Ile Asn Arg Ser Gly  Thr Trp Lys Arg Glu  His Ser Lys 
    2540                 2545                 2550             


His Ser  Ser Ser Leu Pro Arg  Val Ser Thr Trp Arg  Arg Thr Gly 
    2555                 2560                 2565             


Ser Ser  Ser Ser Ile Leu Ser  Ala Ser Ser Glu Ser  Ser Glu Lys 
    2570                 2575                 2580             


Ala Lys  Ser Glu Asp Glu Lys  His Val Asn Ser Ile  Ser Gly Thr 
    2585                 2590                 2595             


Lys Gln  Ser Lys Glu Asn Gln  Val Ser Ala Lys Gly  Thr Trp Arg 
    2600                 2605                 2610             


Lys Ile  Lys Glu Asn Glu Phe  Ser Pro Thr Asn Ser  Thr Ser Gln 
    2615                 2620                 2625             


Thr Val  Ser Ser Gly Ala Thr  Asn Gly Ala Glu Ser  Lys Thr Leu 
    2630                 2635                 2640             


Ile Tyr  Gln Met Ala Pro Ala  Val Ser Lys Thr Glu  Asp Val Trp 
    2645                 2650                 2655             


Val Arg  Ile Glu Asp Cys Pro  Ile Asn Asn Pro Arg  Ser Gly Arg 
    2660                 2665                 2670             


Ser Pro  Thr Gly Asn Thr Pro  Pro Val Ile Asp Ser  Val Ser Glu 
    2675                 2680                 2685             


Lys Ala  Asn Pro Asn Ile Lys  Asp Ser Lys Asp Asn  Gln Ala Lys 
    2690                 2695                 2700             


Gln Asn  Val Gly Asn Gly Ser  Val Pro Met Arg Thr  Val Gly Leu 
    2705                 2710                 2715             


Glu Asn  Arg Leu Asn Ser Phe  Ile Gln Val Asp Ala  Pro Asp Gln 
    2720                 2725                 2730             


Lys Gly  Thr Glu Ile Lys Pro  Gly Gln Asn Asn Pro  Val Pro Val 
    2735                 2740                 2745             


Ser Glu  Thr Asn Glu Ser Ser  Ile Val Glu Arg Thr  Pro Phe Ser 
    2750                 2755                 2760             


Ser Ser  Ser Ser Ser Lys His  Ser Ser Pro Ser Gly  Thr Val Ala 
    2765                 2770                 2775             


Ala Arg  Val Thr Pro Phe Asn  Tyr Asn Pro Ser Pro  Arg Lys Ser 
    2780                 2785                 2790             


Ser Ala  Asp Ser Thr Ser Ala  Arg Pro Ser Gln Ile  Pro Thr Pro 
    2795                 2800                 2805             


Val Asn  Asn Asn Thr Lys Lys  Arg Asp Ser Lys Thr  Asp Ser Thr 
    2810                 2815                 2820             


Glu Ser  Ser Gly Thr Gln Ser  Pro Lys Arg His Ser  Gly Ser Tyr 
    2825                 2830                 2835             


Leu Val  Thr Ser Val 
    2840             


<210>  627
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APCS__Homo_sapiens__NP_001630

<400>  627

Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu 
1               5                   10                  15      


Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg 
            20                  25                  30          


Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro 
        35                  40                  45              


Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg 
    50                  55                  60                  


Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu 
65                  70                  75                  80  


Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg 
                85                  90                  95      


His Lys Val Thr Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His 
            100                 105                 110         


Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile 
        115                 120                 125             


Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val 
    130                 135                 140                 


Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly 
145                 150                 155                 160 


Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu 
                165                 170                 175     


Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr 
            180                 185                 190         


Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn 
        195                 200                 205             


Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val 
    210                 215                 220             


<210>  628
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APEH__Homo_sapiens__NP_001631

<400>  628

Met Glu Arg Gln Val Leu Leu Ser Glu Pro Glu Glu Ala Ala Ala Leu 
1               5                   10                  15      


Tyr Arg Gly Leu Ser Arg Gln Pro Ala Leu Ser Ala Ala Cys Leu Gly 
            20                  25                  30          


Pro Glu Val Thr Thr Gln Tyr Gly Gly Gln Tyr Arg Thr Val His Thr 
        35                  40                  45              


Glu Trp Thr Gln Arg Asp Leu Glu Arg Met Glu Asn Ile Arg Phe Cys 
    50                  55                  60                  


Arg Gln Tyr Leu Val Phe His Asp Gly Asp Ser Val Val Phe Ala Gly 
65                  70                  75                  80  


Pro Ala Gly Asn Ser Val Glu Thr Arg Gly Glu Leu Leu Ser Arg Glu 
                85                  90                  95      


Ser Pro Ser Gly Thr Met Lys Ala Val Leu Arg Lys Ala Gly Gly Thr 
            100                 105                 110         


Gly Pro Gly Glu Glu Lys Gln Phe Leu Glu Val Trp Glu Lys Asn Arg 
        115                 120                 125             


Lys Leu Lys Ser Phe Asn Leu Ser Ala Leu Glu Lys His Gly Pro Val 
    130                 135                 140                 


Tyr Glu Asp Asp Cys Phe Gly Cys Leu Ser Trp Ser His Ser Glu Thr 
145                 150                 155                 160 


His Leu Leu Tyr Val Ala Glu Lys Lys Arg Pro Lys Ala Glu Ser Phe 
                165                 170                 175     


Phe Gln Thr Lys Ala Leu Asp Val Ser Ala Ser Asp Asp Glu Ile Ala 
            180                 185                 190         


Arg Leu Lys Lys Pro Asp Gln Ala Ile Lys Gly Asp Gln Phe Val Phe 
        195                 200                 205             


Tyr Glu Asp Trp Gly Glu Asn Met Val Ser Lys Ser Ile Pro Val Leu 
    210                 215                 220                 


Cys Val Leu Asp Val Glu Ser Gly Asn Ile Ser Val Leu Glu Gly Val 
225                 230                 235                 240 


Pro Glu Asn Val Ser Pro Gly Gln Ala Phe Trp Ala Pro Gly Asp Ala 
                245                 250                 255     


Gly Val Val Phe Val Gly Trp Trp His Glu Pro Phe Arg Leu Gly Ile 
            260                 265                 270         


Arg Phe Cys Thr Asn Arg Arg Ser Ala Leu Tyr Tyr Val Asp Leu Ile 
        275                 280                 285             


Gly Gly Lys Cys Glu Leu Leu Ser Asp Asp Ser Leu Ala Val Ser Ser 
    290                 295                 300                 


Pro Arg Leu Ser Pro Asp Gln Cys Arg Ile Val Tyr Leu Gln Tyr Pro 
305                 310                 315                 320 


Ser Leu Ile Pro His His Gln Cys Ser Gln Leu Cys Leu Tyr Asp Trp 
                325                 330                 335     


Tyr Thr Lys Val Thr Ser Val Val Val Asp Val Val Pro Arg Gln Leu 
            340                 345                 350         


Gly Glu Asn Phe Ser Gly Ile Tyr Cys Ser Leu Leu Pro Leu Gly Cys 
        355                 360                 365             


Trp Ser Ala Asp Ser Gln Arg Val Val Phe Asp Ser Ala Gln Arg Ser 
    370                 375                 380                 


Arg Gln Asp Leu Phe Ala Val Asp Thr Gln Val Gly Thr Val Thr Ser 
385                 390                 395                 400 


Leu Thr Ala Gly Gly Ser Gly Gly Ser Trp Lys Leu Leu Thr Ile Asp 
                405                 410                 415     


Gln Asp Leu Met Val Ala Gln Phe Ser Thr Pro Ser Leu Pro Pro Thr 
            420                 425                 430         


Leu Lys Val Gly Phe Leu Pro Ser Ala Gly Lys Glu Gln Ser Val Leu 
        435                 440                 445             


Trp Val Ser Leu Glu Glu Ala Glu Pro Ile Pro Asp Ile His Trp Gly 
    450                 455                 460                 


Ile Arg Val Leu Gln Pro Pro Pro Glu Gln Glu Asn Val Gln Tyr Ala 
465                 470                 475                 480 


Gly Leu Asp Phe Glu Ala Ile Leu Leu Gln Pro Gly Ser Pro Pro Asp 
                485                 490                 495     


Lys Thr Gln Val Pro Met Val Val Met Pro His Gly Gly Pro His Ser 
            500                 505                 510         


Ser Phe Val Thr Ala Trp Met Leu Phe Pro Ala Met Leu Cys Lys Met 
        515                 520                 525             


Gly Phe Ala Val Leu Leu Val Asn Tyr Arg Gly Ser Thr Gly Phe Gly 
    530                 535                 540                 


Gln Asp Ser Ile Leu Ser Leu Pro Gly Asn Val Gly His Gln Asp Val 
545                 550                 555                 560 


Lys Asp Val Gln Phe Ala Val Glu Gln Val Leu Gln Glu Glu His Phe 
                565                 570                 575     


Asp Ala Ser His Val Ala Leu Met Gly Gly Ser His Gly Gly Phe Ile 
            580                 585                 590         


Ser Cys His Leu Ile Gly Gln Tyr Pro Glu Thr Tyr Arg Ala Cys Val 
        595                 600                 605             


Ala Arg Asn Pro Val Ile Asn Ile Ala Ser Met Leu Gly Ser Thr Asp 
    610                 615                 620                 


Ile Pro Asp Trp Cys Val Val Glu Ala Gly Phe Pro Phe Ser Ser Asp 
625                 630                 635                 640 


Cys Leu Pro Asp Leu Ser Val Trp Ala Glu Met Leu Asp Lys Ser Pro 
                645                 650                 655     


Ile Arg Tyr Ile Pro Gln Val Lys Thr Pro Leu Leu Leu Met Leu Gly 
            660                 665                 670         


Gln Glu Asp Arg Arg Val Pro Phe Lys Gln Gly Met Glu Tyr Tyr Arg 
        675                 680                 685             


Ala Leu Lys Thr Arg Asn Val Pro Val Arg Leu Leu Leu Tyr Pro Lys 
    690                 695                 700                 


Ser Thr His Ala Leu Ser Glu Val Glu Val Glu Ser Asp Ser Phe Met 
705                 710                 715                 720 


Asn Ala Val Leu Trp Leu Arg Thr His Leu Gly Ser 
                725                 730         


<210>  629
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APEX1__Homo_sapiens__XP_005267638

<400>  629

Met Pro Lys Arg Gly Lys Lys Gly Ala Val Ala Glu Asp Gly Asp Glu 
1               5                   10                  15      


Leu Arg Thr Glu Pro Glu Ala Lys Lys Ser Lys Thr Ala Ala Lys Lys 
            20                  25                  30          


Asn Asp Lys Glu Ala Ala Gly Glu Gly Pro Ala Leu Tyr Glu Asp Pro 
        35                  40                  45              


Pro Asp Gln Lys Thr Ser Pro Ser Gly Lys Pro Ala Thr Leu Lys Ile 
    50                  55                  60                  


Cys Ser Trp Asn Val Asp Gly Leu Arg Ala Trp Ile Lys Lys Lys Gly 
65                  70                  75                  80  


Leu Asp Trp Val Lys Glu Glu Ala Pro Asp Ile Leu Cys Leu Gln Glu 
                85                  90                  95      


Thr Lys Cys Ser Glu Asn Lys Leu Pro Ala Glu Leu Gln Glu Leu Pro 
            100                 105                 110         


Gly Leu Ser His Gln Tyr Trp Ser Ala Pro Ser Asp Lys Glu Gly Tyr 
        115                 120                 125             


Ser Gly Val Gly Leu Leu Ser Arg Gln Cys Pro Leu Lys Val Ser Tyr 
    130                 135                 140                 


Gly Ile Gly Asp Glu Glu His Asp Gln Glu Gly Arg Val Ile Val Ala 
145                 150                 155                 160 


Glu Phe Asp Ser Phe Val Leu Val Thr Ala Tyr Val Pro Asn Ala Gly 
                165                 170                 175     


Arg Gly Leu Val Arg Leu Glu Tyr Arg Gln Arg Trp Asp Glu Ala Phe 
            180                 185                 190         


Arg Lys Phe Leu Lys Gly Leu Ala Ser Arg Lys Pro Leu Val Leu Cys 
        195                 200                 205             


Gly Asp Leu Asn Val Ala His Glu Glu Ile Asp Leu Arg Asn Pro Lys 
    210                 215                 220                 


Gly Asn Lys Lys Asn Ala Gly Phe Thr Pro Gln Glu Arg Gln Gly Phe 
225                 230                 235                 240 


Gly Glu Leu Leu Gln Ala Val Pro Leu Ala Asp Ser Phe Arg His Leu 
                245                 250                 255     


Tyr Pro Asn Thr Pro Tyr Ala Tyr Thr Phe Trp Thr Tyr Met Met Asn 
            260                 265                 270         


Ala Arg Ser Lys Asn Val Gly Trp Arg Leu Asp Tyr Phe Leu Leu Ser 
        275                 280                 285             


His Ser Leu Leu Pro Ala Leu Cys Asp Ser Lys Ile Arg Ser Lys Ala 
    290                 295                 300                 


Leu Gly Ser Asp His Cys Pro Ile Thr Leu Tyr Leu Ala Leu 
305                 310                 315             


<210>  630
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APEX2__Homo_sapiens__NP_055296

<400>  630

Met Leu Arg Val Val Ser Trp Asn Ile Asn Gly Ile Arg Arg Pro Leu 
1               5                   10                  15      


Gln Gly Val Ala Asn Gln Glu Pro Ser Asn Cys Ala Ala Val Ala Val 
            20                  25                  30          


Gly Arg Ile Leu Asp Glu Leu Asp Ala Asp Ile Val Cys Leu Gln Glu 
        35                  40                  45              


Thr Lys Val Thr Arg Asp Ala Leu Thr Glu Pro Leu Ala Ile Val Glu 
    50                  55                  60                  


Gly Tyr Asn Ser Tyr Phe Ser Phe Ser Arg Asn Arg Ser Gly Tyr Ser 
65                  70                  75                  80  


Gly Val Ala Thr Phe Cys Lys Asp Asn Ala Thr Pro Val Ala Ala Glu 
                85                  90                  95      


Glu Gly Leu Ser Gly Leu Phe Ala Thr Gln Asn Gly Asp Val Gly Cys 
            100                 105                 110         


Tyr Gly Asn Met Asp Glu Phe Thr Gln Glu Glu Leu Arg Ala Leu Asp 
        115                 120                 125             


Ser Glu Gly Arg Ala Leu Leu Thr Gln His Lys Ile Arg Thr Trp Glu 
    130                 135                 140                 


Gly Lys Glu Lys Thr Leu Thr Leu Ile Asn Val Tyr Cys Pro His Ala 
145                 150                 155                 160 


Asp Pro Gly Arg Pro Glu Arg Leu Val Phe Lys Met Arg Phe Tyr Arg 
                165                 170                 175     


Leu Leu Gln Ile Arg Ala Glu Ala Leu Leu Ala Ala Gly Ser His Val 
            180                 185                 190         


Ile Ile Leu Gly Asp Leu Asn Thr Ala His Arg Pro Ile Asp His Trp 
        195                 200                 205             


Asp Ala Val Asn Leu Glu Cys Phe Glu Glu Asp Pro Gly Arg Lys Trp 
    210                 215                 220                 


Met Asp Ser Leu Leu Ser Asn Leu Gly Cys Gln Ser Ala Ser His Val 
225                 230                 235                 240 


Gly Pro Phe Ile Asp Ser Tyr Arg Cys Phe Gln Pro Lys Gln Glu Gly 
                245                 250                 255     


Ala Phe Thr Cys Trp Ser Ala Val Thr Gly Ala Arg His Leu Asn Tyr 
            260                 265                 270         


Gly Ser Arg Leu Asp Tyr Val Leu Gly Asp Arg Thr Leu Val Ile Asp 
        275                 280                 285             


Thr Phe Gln Ala Ser Phe Leu Leu Pro Glu Val Met Gly Ser Asp His 
    290                 295                 300                 


Cys Pro Val Gly Ala Val Leu Ser Val Ser Ser Val Pro Ala Lys Gln 
305                 310                 315                 320 


Cys Pro Pro Leu Cys Thr Arg Phe Leu Pro Glu Phe Ala Gly Thr Gln 
                325                 330                 335     


Leu Lys Ile Leu Arg Phe Leu Val Pro Leu Glu Gln Ser Pro Val Leu 
            340                 345                 350         


Glu Gln Ser Thr Leu Gln His Asn Asn Gln Thr Arg Val Gln Thr Cys 
        355                 360                 365             


Gln Asn Lys Ala Gln Val Arg Ser Thr Arg Pro Gln Pro Ser Gln Val 
    370                 375                 380                 


Gly Ser Ser Arg Gly Gln Lys Asn Leu Lys Ser Tyr Phe Gln Pro Ser 
385                 390                 395                 400 


Pro Ser Cys Pro Gln Ala Ser Pro Asp Ile Glu Leu Pro Ser Leu Pro 
                405                 410                 415     


Leu Met Ser Ala Leu Met Thr Pro Lys Thr Pro Glu Glu Lys Ala Val 
            420                 425                 430         


Ala Lys Val Val Lys Gly Gln Ala Lys Thr Ser Glu Ala Lys Asp Glu 
        435                 440                 445             


Lys Glu Leu Arg Thr Ser Phe Trp Lys Ser Val Leu Ala Gly Pro Leu 
    450                 455                 460                 


Arg Thr Pro Leu Cys Gly Gly His Arg Glu Pro Cys Val Met Arg Thr 
465                 470                 475                 480 


Val Lys Lys Pro Gly Pro Asn Leu Gly Arg Arg Phe Tyr Met Cys Ala 
                485                 490                 495     


Arg Pro Arg Gly Pro Pro Thr Asp Pro Ser Ser Arg Cys Asn Phe Phe 
            500                 505                 510         


Leu Trp Ser Arg Pro Ser 
        515             


<210>  631
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APH1B__Homo_sapiens__NP_001139118

<400>  631

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Ala Phe Met Thr Leu Val Ile Ile Leu Leu 
        115                 120                 125             


His Val Phe Trp Gly Ile Val Phe Phe Asp Gly Cys Glu Lys Lys Lys 
    130                 135                 140                 


Trp Gly Ile Leu Leu Ile Val Leu Leu Thr His Leu Leu Val Ser Ala 
145                 150                 155                 160 


Gln Thr Phe Ile Ser Ser Tyr Tyr Gly Ile Asn Leu Ala Ser Ala Phe 
                165                 170                 175     


Ile Ile Leu Val Leu Met Gly Thr Trp Ala Phe Leu Ala Ala Gly Gly 
            180                 185                 190         


Ser Cys Arg Ser Leu Lys Leu Cys Leu Leu Cys Gln Asp Lys Asn Phe 
        195                 200                 205             


Leu Leu Tyr Asn Gln Arg Ser Arg 
    210                 215     


<210>  632
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  API5__Homo_sapiens__NP_001136402

<400>  632

Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala Asp 
1               5                   10                  15      


Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile Leu 
            20                  25                  30          


Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln Phe 
        35                  40                  45              


Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala Ile 
    50                  55                  60                  


Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg Arg 
65                  70                  75                  80  


Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu Pro 
                85                  90                  95      


Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser Ala 
            100                 105                 110         


Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met Asp 
        115                 120                 125             


Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly Glu 
    130                 135                 140                 


Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu Lys 
145                 150                 155                 160 


Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile Leu 
                165                 170                 175     


Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe Val 
            180                 185                 190         


Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val Ser 
        195                 200                 205             


Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu Glu 
    210                 215                 220                 


Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu Gln 
225                 230                 235                 240 


Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser Thr 
                245                 250                 255     


Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly Thr 
            260                 265                 270         


Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu Lys 
        275                 280                 285             


Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu Glu 
    290                 295                 300                 


Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro Leu 
305                 310                 315                 320 


Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu Pro 
                325                 330                 335     


Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His Gln 
            340                 345                 350         


Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala Glu 
        355                 360                 365             


Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
    370                 375                 380                 


Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr Gly 
385                 390                 395                 400 


Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu Lys 
                405                 410                 415     


Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile Pro 
            420                 425                 430         


Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln Lys 
        435                 440                 445             


Val Glu Ile Gly Gln Lys Arg Ala Ser Glu Asp Thr Thr Ser Gly Ser 
    450                 455                 460                 


Pro Pro Lys Lys Ser Ser Ala Gly Pro Lys Arg Asp Ala Arg Gln Ile 
465                 470                 475                 480 


Tyr Asn Pro Pro Ser Gly Lys Tyr Ser Ser Asn Leu Gly Asn Phe Asn 
                485                 490                 495     


Tyr Glu Gln Arg Gly Ala Phe Arg Gly Ser Arg Gly Gly Arg Gly Trp 
            500                 505                 510         


Gly Thr Arg Gly Asn Arg Ser Arg Gly Arg Leu Tyr 
        515                 520                 


<210>  633
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APIP__Homo_sapiens__NP_057041

<400>  633

Met Ser Gly Cys Asp Ala Arg Glu Gly Asp Cys Cys Ser Arg Arg Cys 
1               5                   10                  15      


Gly Ala Gln Asp Lys Glu His Pro Arg Tyr Leu Ile Pro Glu Leu Cys 
            20                  25                  30          


Lys Gln Phe Tyr His Leu Gly Trp Val Thr Gly Thr Gly Gly Gly Ile 
        35                  40                  45              


Ser Leu Lys His Gly Asp Glu Ile Tyr Ile Ala Pro Ser Gly Val Gln 
    50                  55                  60                  


Lys Glu Arg Ile Gln Pro Glu Asp Met Phe Val Cys Asp Ile Asn Glu 
65                  70                  75                  80  


Lys Asp Ile Ser Gly Pro Ser Pro Ser Lys Lys Leu Lys Lys Ser Gln 
                85                  90                  95      


Cys Thr Pro Leu Phe Met Asn Ala Tyr Thr Met Arg Gly Ala Gly Ala 
            100                 105                 110         


Val Ile His Thr His Ser Lys Ala Ala Val Met Ala Thr Leu Leu Phe 
        115                 120                 125             


Pro Gly Arg Glu Phe Lys Ile Thr His Gln Glu Met Ile Lys Gly Ile 
    130                 135                 140                 


Lys Lys Cys Thr Ser Gly Gly Tyr Tyr Arg Tyr Asp Asp Met Leu Val 
145                 150                 155                 160 


Val Pro Ile Ile Glu Asn Thr Pro Glu Glu Lys Asp Leu Lys Asp Arg 
                165                 170                 175     


Met Ala His Ala Met Asn Glu Tyr Pro Asp Ser Cys Ala Val Leu Val 
            180                 185                 190         


Arg Arg His Gly Val Tyr Val Trp Gly Glu Thr Trp Glu Lys Ala Lys 
        195                 200                 205             


Thr Met Cys Glu Cys Tyr Asp Tyr Leu Phe Asp Ile Ala Val Ser Met 
    210                 215                 220                 


Lys Lys Val Gly Leu Asp Pro Ser Gln Leu Pro Val Gly Glu Asn Gly 
225                 230                 235                 240 


Ile Val 
        


<210>  634
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APLN__Homo_sapiens__NP_059109

<400>  634

Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Thr Ala Val Cys Gly Gly Ser Leu Met Pro Leu Pro Asp Gly Asn 
            20                  25                  30          


Gly Leu Glu Asp Gly Asn Val Arg His Leu Val Gln Pro Arg Gly Ser 
        35                  40                  45              


Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  635
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APLNR__Homo_sapiens__NP_005152

<400>  635

Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln 
1               5                   10                  15      


Ser Glu Cys Glu Tyr Thr Asp Trp Lys Ser Ser Gly Ala Leu Ile Pro 
            20                  25                  30          


Ala Ile Tyr Met Leu Val Phe Leu Leu Gly Thr Thr Gly Asn Gly Leu 
        35                  40                  45              


Val Leu Trp Thr Val Phe Arg Ser Ser Arg Glu Lys Arg Arg Ser Ala 
    50                  55                  60                  


Asp Ile Phe Ile Ala Ser Leu Ala Val Ala Asp Leu Thr Phe Val Val 
65                  70                  75                  80  


Thr Leu Pro Leu Trp Ala Thr Tyr Thr Tyr Arg Asp Tyr Asp Trp Pro 
                85                  90                  95      


Phe Gly Thr Phe Phe Cys Lys Leu Ser Ser Tyr Leu Ile Phe Val Asn 
            100                 105                 110         


Met Tyr Ala Ser Val Phe Cys Leu Thr Gly Leu Ser Phe Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Arg Pro Val Ala Asn Ala Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Ser Gly Ala Val Ala Thr Ala Val Leu Trp Val Leu Ala Ala Leu Leu 
145                 150                 155                 160 


Ala Met Pro Val Met Val Leu Arg Thr Thr Gly Asp Leu Glu Asn Thr 
                165                 170                 175     


Thr Lys Val Gln Cys Tyr Met Asp Tyr Ser Met Val Ala Thr Val Ser 
            180                 185                 190         


Ser Glu Trp Ala Trp Glu Val Gly Leu Gly Val Ser Ser Thr Thr Val 
        195                 200                 205             


Gly Phe Val Val Pro Phe Thr Ile Met Leu Thr Cys Tyr Phe Phe Ile 
    210                 215                 220                 


Ala Gln Thr Ile Ala Gly His Phe Arg Lys Glu Arg Ile Glu Gly Leu 
225                 230                 235                 240 


Arg Lys Arg Arg Arg Leu Leu Ser Ile Ile Val Val Leu Val Val Thr 
                245                 250                 255     


Phe Ala Leu Cys Trp Met Pro Tyr His Leu Val Lys Thr Leu Tyr Met 
            260                 265                 270         


Leu Gly Ser Leu Leu His Trp Pro Cys Asp Phe Asp Leu Phe Leu Met 
        275                 280                 285             


Asn Ile Phe Pro Tyr Cys Thr Cys Ile Ser Tyr Val Asn Ser Cys Leu 
    290                 295                 300                 


Asn Pro Phe Leu Tyr Ala Phe Phe Asp Pro Arg Phe Arg Gln Ala Cys 
305                 310                 315                 320 


Thr Ser Met Leu Cys Cys Gly Gln Ser Arg Cys Ala Gly Thr Ser His 
                325                 330                 335     


Ser Ser Ser Gly Glu Lys Ser Ala Ser Tyr Ser Ser Gly His Ser Gln 
            340                 345                 350         


Gly Pro Gly Pro Asn Met Gly Lys Gly Gly Glu Gln Met His Glu Lys 
        355                 360                 365             


Ser Ile Pro Tyr Ser Gln Glu Thr Leu Val Val Asp 
    370                 375                 380 


<210>  636
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APLP1__Homo_sapiens__NP_001019978

<400>  636

Met Gly Pro Ala Ser Pro Ala Ala Arg Gly Leu Ser Arg Arg Pro Gly 
1               5                   10                  15      


Gln Pro Pro Leu Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Arg 
            20                  25                  30          


Ala Gln Pro Ala Ile Gly Ser Leu Ala Gly Gly Ser Pro Gly Ala Ala 
        35                  40                  45              


Glu Ala Pro Gly Ser Ala Gln Val Ala Gly Leu Cys Gly Arg Leu Thr 
    50                  55                  60                  


Leu His Arg Asp Leu Arg Thr Gly Arg Trp Glu Pro Asp Pro Gln Arg 
65                  70                  75                  80  


Ser Arg Arg Cys Leu Arg Asp Pro Gln Arg Val Leu Glu Tyr Cys Arg 
                85                  90                  95      


Gln Met Tyr Pro Glu Leu Gln Ile Ala Arg Val Glu Gln Ala Thr Gln 
            100                 105                 110         


Ala Ile Pro Met Glu Arg Trp Cys Gly Gly Ser Arg Ser Gly Ser Cys 
        115                 120                 125             


Ala His Pro His His Gln Val Val Pro Phe Arg Cys Leu Pro Gly Glu 
    130                 135                 140                 


Phe Val Ser Glu Ala Leu Leu Val Pro Glu Gly Cys Arg Phe Leu His 
145                 150                 155                 160 


Gln Glu Arg Met Asp Gln Cys Glu Ser Ser Thr Arg Arg His Gln Glu 
                165                 170                 175     


Ala Gln Glu Ala Cys Ser Ser Gln Gly Leu Ile Leu His Gly Ser Gly 
            180                 185                 190         


Met Leu Leu Pro Cys Gly Ser Asp Arg Phe Arg Gly Val Glu Tyr Val 
        195                 200                 205             


Cys Cys Pro Pro Pro Gly Thr Pro Asp Pro Ser Gly Thr Ala Val Gly 
    210                 215                 220                 


Asp Pro Ser Thr Arg Ser Trp Pro Pro Gly Ser Arg Val Glu Gly Ala 
225                 230                 235                 240 


Glu Asp Glu Glu Glu Glu Glu Ser Phe Pro Gln Pro Val Asp Asp Tyr 
                245                 250                 255     


Phe Val Glu Pro Pro Gln Ala Glu Glu Glu Glu Glu Thr Val Pro Pro 
            260                 265                 270         


Pro Ser Ser His Thr Leu Ala Val Val Gly Lys Val Thr Pro Thr Pro 
        275                 280                 285             


Arg Pro Thr Asp Gly Val Asp Ile Tyr Phe Gly Met Pro Gly Glu Ile 
    290                 295                 300                 


Ser Glu His Glu Gly Phe Leu Arg Ala Lys Met Asp Leu Glu Glu Arg 
305                 310                 315                 320 


Arg Met Arg Gln Ile Asn Glu Val Met Arg Glu Trp Ala Met Ala Asp 
                325                 330                 335     


Asn Gln Ser Lys Asn Leu Pro Lys Ala Asp Arg Gln Ala Leu Asn Glu 
            340                 345                 350         


His Phe Gln Ser Ile Leu Gln Thr Leu Glu Glu Gln Val Ser Gly Glu 
        355                 360                 365             


Arg Gln Arg Leu Val Glu Thr His Ala Thr Arg Val Ile Ala Leu Ile 
    370                 375                 380                 


Asn Asp Gln Arg Arg Ala Ala Leu Glu Gly Phe Leu Ala Ala Leu Gln 
385                 390                 395                 400 


Ala Asp Pro Pro Gln Ala Glu Arg Val Leu Leu Ala Leu Arg Arg Tyr 
                405                 410                 415     


Leu Arg Ala Glu Gln Lys Glu Gln Arg His Thr Leu Arg His Tyr Gln 
            420                 425                 430         


His Val Ala Ala Val Asp Pro Glu Lys Ala Gln Gln Met Arg Phe Gln 
        435                 440                 445             


Val His Thr His Leu Gln Val Ile Glu Glu Arg Val Asn Gln Ser Leu 
    450                 455                 460                 


Gly Leu Leu Asp Gln Asn Pro His Leu Ala Gln Glu Leu Arg Pro Gln 
465                 470                 475                 480 


Ile Gln Glu Leu Leu His Ser Glu His Leu Gly Pro Ser Glu Leu Glu 
                485                 490                 495     


Ala Pro Ala Pro Gly Gly Ser Ser Glu Asp Lys Gly Gly Leu Gln Pro 
            500                 505                 510         


Pro Asp Ser Lys Asp Ala Asp Thr Pro Met Thr Leu Pro Lys Gly Ser 
        515                 520                 525             


Thr Glu Gln Asp Ala Ala Ser Pro Glu Lys Glu Lys Met Asn Pro Leu 
    530                 535                 540                 


Glu Gln Tyr Glu Arg Lys Val Asn Ala Ser Val Pro Arg Gly Phe Pro 
545                 550                 555                 560 


Phe His Ser Ser Glu Ile Gln Arg Asp Glu Leu Ala Pro Ala Gly Thr 
                565                 570                 575     


Gly Val Ser Arg Glu Ala Val Ser Gly Leu Leu Ile Met Gly Ala Gly 
            580                 585                 590         


Gly Gly Ser Leu Ile Val Leu Ser Met Leu Leu Leu Arg Arg Lys Lys 
        595                 600                 605             


Pro Tyr Gly Ala Ile Ser His Gly Val Val Glu Val Asp Pro Met Leu 
    610                 615                 620                 


Thr Leu Glu Glu Gln Gln Leu Arg Glu Leu Gln Arg His Gly Tyr Glu 
625                 630                 635                 640 


Asn Pro Thr Tyr Arg Phe Leu Glu Glu Arg Pro 
                645                 650     


<210>  637
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APLP2__Homo_sapiens__NP_001135748

<400>  637

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Gly Glu Phe Val Ser Asp Val Leu Leu 
    130                 135                 140                 


Val Pro Glu Lys Cys Gln Phe Phe His Lys Glu Arg Met Glu Val Cys 
145                 150                 155                 160 


Glu Asn His Gln His Trp His Thr Val Val Lys Glu Ala Cys Leu Thr 
                165                 170                 175     


Gln Gly Met Thr Leu Tyr Ser Tyr Gly Met Leu Leu Pro Cys Gly Val 
            180                 185                 190         


Asp Gln Phe His Gly Thr Glu Tyr Val Cys Cys Pro Gln Thr Lys Ile 
        195                 200                 205             


Ile Gly Ser Val Ser Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
    210                 215                 220                 


Glu Glu Glu Asp Glu Glu Glu Asp Tyr Asp Val Tyr Lys Ser Glu Phe 
225                 230                 235                 240 


Pro Thr Glu Ala Asp Leu Glu Asp Phe Thr Glu Ala Ala Val Asp Glu 
                245                 250                 255     


Asp Asp Glu Asp Glu Glu Glu Gly Glu Glu Val Val Glu Asp Arg Asp 
            260                 265                 270         


Tyr Tyr Tyr Asp Thr Phe Lys Gly Asp Asp Tyr Asn Glu Glu Asn Pro 
        275                 280                 285             


Thr Glu Pro Gly Ser Asp Gly Thr Met Ser Asp Lys Glu Ile Thr His 
    290                 295                 300                 


Asp Val Lys Ala Val Cys Ser Gln Glu Ala Met Thr Gly Pro Cys Arg 
305                 310                 315                 320 


Ala Val Met Pro Arg Trp Tyr Phe Asp Leu Ser Lys Gly Lys Cys Val 
                325                 330                 335     


Arg Phe Ile Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Glu Ser 
            340                 345                 350         


Glu Asp Tyr Cys Met Ala Val Cys Lys Ala Met Ile Pro Pro Thr Pro 
        355                 360                 365             


Leu Pro Thr Asn Asp Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp 
    370                 375                 380                 


Asn Glu His Ala Arg Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg 
385                 390                 395                 400 


His Arg Asn Arg Met Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu 
                405                 410                 415     


Leu Gln Ala Lys Asn Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln 
            420                 425                 430         


His Phe Gln Ala Met Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu 
        435                 440                 445             


Lys Gln Gln Leu Val Glu Thr His Leu Ala Arg Val Glu Ala Met Leu 
    450                 455                 460                 


Asn Asp Arg Arg Arg Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln 
465                 470                 475                 480 


Ser Asp Pro Pro Arg Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr 
                485                 490                 495     


Val Arg Ala Glu Asn Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln 
            500                 505                 510         


His Val Leu Ala Val Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln 
        515                 520                 525             


Val Met Thr His Leu His Val Ile Glu Glu Arg Arg Asn Gln Ser Leu 
    530                 535                 540                 


Ser Leu Leu Tyr Lys Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu 
545                 550                 555                 560 


Ile Asp Glu Leu Leu Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr 
                565                 570                 575     


Ala Ser Ile Ser Glu Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu 
            580                 585                 590         


Ser Glu Glu Ile Pro Pro Phe His Pro Phe His Pro Phe Pro Ala Leu 
        595                 600                 605             


Pro Glu Asn Glu Gly Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile 
    610                 615                 620                 


Gly Ala Glu Glu Lys Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn 
625                 630                 635                 640 


Met Val Ile Asp Glu Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala 
                645                 650                 655     


Glu Arg Val Gly Gly Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu 
            660                 665                 670         


Arg Glu Asp Phe Ser Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val 
        675                 680                 685             


Ile Ala Val Ala Ile Ala Thr Val Ile Val Ile Ser Leu Val Met Leu 
    690                 695                 700                 


Arg Lys Arg Gln Tyr Gly Thr Ile Ser His Gly Ile Val Glu Val Asp 
705                 710                 715                 720 


Pro Met Leu Thr Pro Glu Glu Arg His Leu Asn Lys Met Gln Asn His 
                725                 730                 735     


Gly Tyr Glu Asn Pro Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
            740                 745                 750     


<210>  638
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOA1BP__Homo_sapiens__NP_658985

<400>  638

Met Ser Arg Leu Arg Ala Leu Leu Gly Leu Gly Leu Leu Val Ala Gly 
1               5                   10                  15      


Ser Arg Val Pro Arg Ile Lys Ser Gln Thr Ile Ala Cys Arg Ser Gly 
            20                  25                  30          


Pro Thr Trp Trp Gly Pro Gln Arg Leu Asn Ser Gly Gly Arg Trp Asp 
        35                  40                  45              


Ser Glu Val Met Ala Ser Thr Val Val Lys Tyr Leu Ser Gln Glu Glu 
    50                  55                  60                  


Ala Gln Ala Val Asp Gln Glu Leu Phe Asn Glu Tyr Gln Phe Ser Val 
65                  70                  75                  80  


Asp Gln Leu Met Glu Leu Ala Gly Leu Ser Cys Ala Thr Ala Ile Ala 
                85                  90                  95      


Lys Ala Tyr Pro Pro Thr Ser Met Ser Arg Ser Pro Pro Thr Val Leu 
            100                 105                 110         


Val Ile Cys Gly Pro Gly Asn Asn Gly Gly Asp Gly Leu Val Cys Ala 
        115                 120                 125             


Arg His Leu Lys Leu Phe Gly Tyr Glu Pro Thr Ile Tyr Tyr Pro Lys 
    130                 135                 140                 


Arg Pro Asn Lys Pro Leu Phe Thr Ala Leu Val Thr Gln Cys Gln Lys 
145                 150                 155                 160 


Met Asp Ile Pro Phe Leu Gly Glu Met Pro Ala Glu Pro Met Thr Ile 
                165                 170                 175     


Asp Glu Leu Tyr Glu Leu Val Val Asp Ala Ile Phe Gly Phe Ser Phe 
            180                 185                 190         


Lys Gly Asp Val Arg Glu Pro Phe His Ser Ile Leu Ser Val Leu Lys 
        195                 200                 205             


Gly Leu Thr Val Pro Ile Ala Ser Ile Asp Ile Pro Ser Gly Trp Asp 
    210                 215                 220                 


Val Glu Lys Gly Asn Ala Gly Gly Ile Gln Pro Asp Leu Leu Ile Ser 
225                 230                 235                 240 


Leu Thr Ala Pro Lys Lys Ser Ala Thr Gln Phe Thr Gly Arg Tyr His 
                245                 250                 255     


Tyr Leu Gly Gly Arg Phe Val Pro Pro Ala Leu Glu Lys Lys Tyr Gln 
            260                 265                 270         


Leu Asn Leu Pro Pro Tyr Pro Asp Thr Glu Cys Val Tyr Arg Leu Gln 
        275                 280                 285             


<210>  639
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOA2__Homo_sapiens__NP_001634

<400>  639

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
65                  70                  75                  80  


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln 
                85                  90                  95      


Pro Ala Thr Gln 
            100 


<210>  640
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOA4__Homo_sapiens__NP_000473

<400>  640

Met Phe Leu Lys Ala Val Val Leu Thr Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Gly Ala Arg Ala Glu Val Ser Ala Asp Gln Val Ala Thr Val Met Trp 
            20                  25                  30          


Asp Tyr Phe Ser Gln Leu Ser Asn Asn Ala Lys Glu Ala Val Glu His 
        35                  40                  45              


Leu Gln Lys Ser Glu Leu Thr Gln Gln Leu Asn Ala Leu Phe Gln Asp 
    50                  55                  60                  


Lys Leu Gly Glu Val Asn Thr Tyr Ala Gly Asp Leu Gln Lys Lys Leu 
65                  70                  75                  80  


Val Pro Phe Ala Thr Glu Leu His Glu Arg Leu Ala Lys Asp Ser Glu 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Gly Lys Glu Leu Glu Glu Leu Arg Ala Arg 
            100                 105                 110         


Leu Leu Pro His Ala Asn Glu Val Ser Gln Lys Ile Gly Asp Asn Leu 
        115                 120                 125             


Arg Glu Leu Gln Gln Arg Leu Glu Pro Tyr Ala Asp Gln Leu Arg Thr 
    130                 135                 140                 


Gln Val Ser Thr Gln Ala Glu Gln Leu Arg Arg Gln Leu Thr Pro Tyr 
145                 150                 155                 160 


Ala Gln Arg Met Glu Arg Val Leu Arg Glu Asn Ala Asp Ser Leu Gln 
                165                 170                 175     


Ala Ser Leu Arg Pro His Ala Asp Glu Leu Lys Ala Lys Ile Asp Gln 
            180                 185                 190         


Asn Val Glu Glu Leu Lys Gly Arg Leu Thr Pro Tyr Ala Asp Glu Phe 
        195                 200                 205             


Lys Val Lys Ile Asp Gln Thr Val Glu Glu Leu Arg Arg Ser Leu Ala 
    210                 215                 220                 


Pro Tyr Ala Gln Asp Thr Gln Glu Lys Leu Asn His Gln Leu Glu Gly 
225                 230                 235                 240 


Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys Ala Arg Ile 
                245                 250                 255     


Ser Ala Ser Ala Glu Glu Leu Arg Gln Arg Leu Ala Pro Leu Ala Glu 
            260                 265                 270         


Asp Val Arg Gly Asn Leu Arg Gly Asn Thr Glu Gly Leu Gln Lys Ser 
        275                 280                 285             


Leu Ala Glu Leu Gly Gly His Leu Asp Gln Gln Val Glu Glu Phe Arg 
    290                 295                 300                 


Arg Arg Val Glu Pro Tyr Gly Glu Asn Phe Asn Lys Ala Leu Val Gln 
305                 310                 315                 320 


Gln Met Glu Gln Leu Arg Gln Lys Leu Gly Pro His Ala Gly Asp Val 
                325                 330                 335     


Glu Gly His Leu Ser Phe Leu Glu Lys Asp Leu Arg Asp Lys Val Asn 
            340                 345                 350         


Ser Phe Phe Ser Thr Phe Lys Glu Lys Glu Ser Gln Asp Lys Thr Leu 
        355                 360                 365             


Ser Leu Pro Glu Leu Glu Gln Gln Gln Glu Gln Gln Gln Glu Gln Gln 
    370                 375                 380                 


Gln Glu Gln Val Gln Met Leu Ala Pro Leu Glu Ser 
385                 390                 395     


<210>  641
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOA5__Homo_sapiens__NP_001160070

<400>  641

Met Ala Ser Met Ala Ala Val Leu Thr Trp Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Ala Phe Ser Ala Thr Gln Ala Arg Lys Gly Phe Trp Asp Tyr Phe Ser 
            20                  25                  30          


Gln Thr Ser Gly Asp Lys Gly Arg Val Glu Gln Ile His Gln Gln Lys 
        35                  40                  45              


Met Ala Arg Glu Pro Ala Thr Leu Lys Asp Ser Leu Glu Gln Asp Leu 
    50                  55                  60                  


Asn Asn Met Asn Lys Phe Leu Glu Lys Leu Arg Pro Leu Ser Gly Ser 
65                  70                  75                  80  


Glu Ala Pro Arg Leu Pro Gln Asp Pro Val Gly Met Arg Arg Gln Leu 
                85                  90                  95      


Gln Glu Glu Leu Glu Glu Val Lys Ala Arg Leu Gln Pro Tyr Met Ala 
            100                 105                 110         


Glu Ala His Glu Leu Val Gly Trp Asn Leu Glu Gly Leu Arg Gln Gln 
        115                 120                 125             


Leu Lys Pro Tyr Thr Met Asp Leu Met Glu Gln Val Ala Leu Arg Val 
    130                 135                 140                 


Gln Glu Leu Gln Glu Gln Leu Arg Val Val Gly Glu Asp Thr Lys Ala 
145                 150                 155                 160 


Gln Leu Leu Gly Gly Val Asp Glu Ala Trp Ala Leu Leu Gln Gly Leu 
                165                 170                 175     


Gln Ser Arg Val Val His His Thr Gly Arg Phe Lys Glu Leu Phe His 
            180                 185                 190         


Pro Tyr Ala Glu Ser Leu Val Ser Gly Ile Gly Arg His Val Gln Glu 
        195                 200                 205             


Leu His Arg Ser Val Ala Pro His Ala Pro Ala Ser Pro Ala Arg Leu 
    210                 215                 220                 


Ser Arg Cys Val Gln Val Leu Ser Arg Lys Leu Thr Leu Lys Ala Lys 
225                 230                 235                 240 


Ala Leu His Ala Arg Ile Gln Gln Asn Leu Asp Gln Leu Arg Glu Glu 
                245                 250                 255     


Leu Ser Arg Ala Phe Ala Gly Thr Gly Thr Glu Glu Gly Ala Gly Pro 
            260                 265                 270         


Asp Pro Gln Met Leu Ser Glu Glu Val Arg Gln Arg Leu Gln Ala Phe 
        275                 280                 285             


Arg Gln Asp Thr Tyr Leu Gln Ile Ala Ala Phe Thr Arg Ala Ile Asp 
    290                 295                 300                 


Gln Glu Thr Glu Glu Val Gln Gln Gln Leu Ala Pro Pro Pro Pro Gly 
305                 310                 315                 320 


His Ser Ala Phe Ala Pro Glu Phe Gln Gln Thr Asp Ser Gly Lys Val 
                325                 330                 335     


Leu Ser Lys Leu Gln Ala Arg Leu Asp Asp Leu Trp Glu Asp Ile Thr 
            340                 345                 350         


His Ser Leu His Asp Gln Gly His Ser His Leu Gly Asp Pro 
        355                 360                 365     


<210>  642
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC1__Homo_sapiens__NP_001291495

<400>  642

Met Thr Ser Glu Lys Gly Pro Ser Thr Gly Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro Trp Glu Phe Asp Val Phe Tyr Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Cys Leu Leu Tyr Glu Ile Lys Trp Gly Met Ser Arg 
        35                  40                  45              


Lys Ile Trp Arg Ser Ser Gly Lys Asn Thr Thr Asn His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Lys Lys Phe Thr Ser Glu Arg Asp Phe His Pro Ser Met 
65                  70                  75                  80  


Ser Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Trp Glu Cys 
                85                  90                  95      


Ser Gln Ala Ile Arg Glu Phe Leu Ser Arg His Pro Gly Val Thr Leu 
            100                 105                 110         


Val Ile Tyr Val Ala Arg Leu Phe Trp His Met Asp Gln Gln Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Val Asn Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Arg Ala Ser Glu Tyr Tyr His Cys Trp Arg Asn Phe Val Asn Tyr Pro 
145                 150                 155                 160 


Pro Gly Asp Glu Ala His Trp Pro Gln Tyr Pro Pro Leu Trp Met Met 
                165                 170                 175     


Leu Tyr Ala Leu Glu Leu His Cys Ile Ile Leu Ser Leu Pro Pro Cys 
            180                 185                 190         


Leu Lys Ile Ser Arg Arg Trp Gln Asn His Leu Thr Phe Phe Arg Leu 
        195                 200                 205             


His Leu Gln Asn Cys His Tyr Gln Thr Ile Pro Pro His Ile Leu Leu 
    210                 215                 220                 


Ala Thr Gly Leu Ile His Pro Ser Val Ala Trp Arg 
225                 230                 235     


<210>  643
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC2__Homo_sapiens__NP_006780

<400>  643

Met Ala Gln Lys Glu Glu Ala Ala Val Ala Thr Glu Ala Ala Ser Gln 
1               5                   10                  15      


Asn Gly Glu Asp Leu Glu Asn Leu Asp Asp Pro Glu Lys Leu Lys Glu 
            20                  25                  30          


Leu Ile Glu Leu Pro Pro Phe Glu Ile Val Thr Gly Glu Arg Leu Pro 
        35                  40                  45              


Ala Asn Phe Phe Lys Phe Gln Phe Arg Asn Val Glu Tyr Ser Ser Gly 
    50                  55                  60                  


Arg Asn Lys Thr Phe Leu Cys Tyr Val Val Glu Ala Gln Gly Lys Gly 
65                  70                  75                  80  


Gly Gln Val Gln Ala Ser Arg Gly Tyr Leu Glu Asp Glu His Ala Ala 
                85                  90                  95      


Ala His Ala Glu Glu Ala Phe Phe Asn Thr Ile Leu Pro Ala Phe Asp 
            100                 105                 110         


Pro Ala Leu Arg Tyr Asn Val Thr Trp Tyr Val Ser Ser Ser Pro Cys 
        115                 120                 125             


Ala Ala Cys Ala Asp Arg Ile Ile Lys Thr Leu Ser Lys Thr Lys Asn 
    130                 135                 140                 


Leu Arg Leu Leu Ile Leu Val Gly Arg Leu Phe Met Trp Glu Glu Pro 
145                 150                 155                 160 


Glu Ile Gln Ala Ala Leu Lys Lys Leu Lys Glu Ala Gly Cys Lys Leu 
                165                 170                 175     


Arg Ile Met Lys Pro Gln Asp Phe Glu Tyr Val Trp Gln Asn Phe Val 
            180                 185                 190         


Glu Gln Glu Glu Gly Glu Ser Lys Ala Phe Gln Pro Trp Glu Asp Ile 
        195                 200                 205             


Gln Glu Asn Phe Leu Tyr Tyr Glu Glu Lys Leu Ala Asp Ile Leu Lys 
    210                 215                 220                 


<210>  644
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3A_B__Homo_sapiens__XP_011545347

<400>  644

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  645
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3B__Homo_sapiens__NP_001257340

<400>  645

Met Asn Pro Gln Ile Arg Asn Pro Met Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Tyr Asp Asn Phe Glu Asn Glu Pro Ile Leu Tyr Gly Arg Ser Tyr 
            20                  25                  30          


Thr Trp Leu Cys Tyr Glu Val Lys Ile Lys Arg Gly Arg Ser Asn Leu 
        35                  40                  45              


Leu Trp Asp Thr Gly Val Phe Arg Gly Gln Val Tyr Phe Lys Pro Gln 
    50                  55                  60                  


Tyr His Ala Glu Met Cys Phe Leu Ser Trp Phe Cys Gly Asn Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Lys Cys Phe Gln Ile Thr Trp Phe Val Ser Trp Thr Pro 
                85                  90                  95      


Cys Pro Asp Cys Val Ala Lys Leu Ala Glu Phe Leu Ser Glu His Pro 
            100                 105                 110         


Asn Val Thr Leu Thr Ile Ser Ala Ala Arg Leu Tyr Tyr Tyr Trp Glu 
        115                 120                 125             


Arg Asp Tyr Arg Arg Ala Leu Cys Arg Leu Ser Gln Ala Gly Ala Arg 
    130                 135                 140                 


Val Lys Ile Met Asp Tyr Glu Glu Phe Ala Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Glu Gly Gln Gln Phe Met Pro Trp Tyr Lys Phe Asp Glu 
                165                 170                 175     


Asn Tyr Ala Phe Leu His Arg Thr Leu Lys Glu Ile Leu Arg Tyr Leu 
            180                 185                 190         


Met Asp Pro Asp Thr Phe Thr Phe Asn Phe Asn Asn Asp Pro Leu Val 
        195                 200                 205             


Leu Arg Arg Arg Gln Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp 
    210                 215                 220                 


Asn Gly Thr Trp Val Leu Met Asp Gln His Met Gly Phe Leu Cys Asn 
225                 230                 235                 240 


Glu Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
                245                 250                 255     


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
            260                 265                 270         


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
        275                 280                 285             


Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
    290                 295                 300                 


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Glu Tyr Cys Trp 
305                 310                 315                 320 


Asp Thr Phe Val Tyr Arg Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
                325                 330                 335     


Leu Glu Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
            340                 345                 350         


Gln Asn Gln Gly Asn 
        355         


<210>  646
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3C__Homo_sapiens__NP_055323

<400>  646

Met Asn Pro Gln Ile Arg Asn Pro Met Lys Ala Met Tyr Pro Gly Thr 
1               5                   10                  15      


Phe Tyr Phe Gln Phe Lys Asn Leu Trp Glu Ala Asn Asp Arg Asn Glu 
            20                  25                  30          


Thr Trp Leu Cys Phe Thr Val Glu Gly Ile Lys Arg Arg Ser Val Val 
        35                  40                  45              


Ser Trp Lys Thr Gly Val Phe Arg Asn Gln Val Asp Ser Glu Thr His 
    50                  55                  60                  


Cys His Ala Glu Arg Cys Phe Leu Ser Trp Phe Cys Asp Asp Ile Leu 
65                  70                  75                  80  


Ser Pro Asn Thr Lys Tyr Gln Val Thr Trp Tyr Thr Ser Trp Ser Pro 
                85                  90                  95      


Cys Pro Asp Cys Ala Gly Glu Val Ala Glu Phe Leu Ala Arg His Ser 
            100                 105                 110         


Asn Val Asn Leu Thr Ile Phe Thr Ala Arg Leu Tyr Tyr Phe Gln Tyr 
        115                 120                 125             


Pro Cys Tyr Gln Glu Gly Leu Arg Ser Leu Ser Gln Glu Gly Val Ala 
    130                 135                 140                 


Val Glu Ile Met Asp Tyr Glu Asp Phe Lys Tyr Cys Trp Glu Asn Phe 
145                 150                 155                 160 


Val Tyr Asn Asp Asn Glu Pro Phe Lys Pro Trp Lys Gly Leu Lys Thr 
                165                 170                 175     


Asn Phe Arg Leu Leu Lys Arg Arg Leu Arg Glu Ser Leu Gln 
            180                 185                 190 


<210>  647
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3F__Homo_sapiens__NP_001006667

<400>  647

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Arg 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Pro Arg Ser Phe Ile Arg 
    50                  55                  60                  


Ala Pro Phe Gln Val Leu Ser Ser Pro Phe Gly Gln Cys Ala Pro Pro 
65                  70                  75                  80  


His Gly Thr Ala Gln Val Gln Trp Pro Pro Gln Leu Thr Ala Gly Arg 
                85                  90                  95      


Glu Gln Gly Arg Pro 
            100     


<210>  648
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3G__Homo_sapiens__NP_068594

<400>  648

Met Lys Pro His Phe Arg Asn Thr Val Glu Arg Met Tyr Arg Asp Thr 
1               5                   10                  15      


Phe Ser Tyr Asn Phe Tyr Asn Arg Pro Ile Leu Ser Arg Arg Asn Thr 
            20                  25                  30          


Val Trp Leu Cys Tyr Glu Val Lys Thr Lys Gly Pro Ser Arg Pro Pro 
        35                  40                  45              


Leu Asp Ala Lys Ile Phe Arg Gly Gln Val Tyr Ser Glu Leu Lys Tyr 
    50                  55                  60                  


His Pro Glu Met Arg Phe Phe His Trp Phe Ser Lys Trp Arg Lys Leu 
65                  70                  75                  80  


His Arg Asp Gln Glu Tyr Glu Val Thr Trp Tyr Ile Ser Trp Ser Pro 
                85                  90                  95      


Cys Thr Lys Cys Thr Arg Asp Met Ala Thr Phe Leu Ala Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Leu Thr Ile Phe Val Ala Arg Leu Tyr Tyr Phe Trp Asp 
        115                 120                 125             


Pro Asp Tyr Gln Glu Ala Leu Arg Ser Leu Cys Gln Lys Arg Asp Gly 
    130                 135                 140                 


Pro Arg Ala Thr Met Lys Ile Met Asn Tyr Asp Glu Phe Gln His Cys 
145                 150                 155                 160 


Trp Ser Lys Phe Val Tyr Ser Gln Arg Glu Leu Phe Glu Pro Trp Asn 
                165                 170                 175     


Asn Leu Pro Lys Tyr Tyr Ile Leu Leu His Ile Met Leu Gly Glu Ile 
            180                 185                 190         


Leu Arg His Ser Met Asp Pro Pro Thr Phe Thr Phe Asn Phe Asn Asn 
        195                 200                 205             


Glu Pro Trp Val Arg Gly Arg His Glu Thr Tyr Leu Cys Tyr Glu Val 
    210                 215                 220                 


Glu Arg Met His Asn Asp Thr Trp Val Leu Leu Asn Gln Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Cys Asn Gln Ala Pro His Lys His Gly Phe Leu Glu Gly Arg 
                245                 250                 255     


His Ala Glu Leu Cys Phe Leu Asp Val Ile Pro Phe Trp Lys Leu Asp 
            260                 265                 270         


Leu Asp Gln Asp Tyr Arg Val Thr Cys Phe Thr Ser Trp Ser Pro Cys 
        275                 280                 285             


Phe Ser Cys Ala Gln Glu Met Ala Lys Phe Ile Ser Lys Asn Lys His 
    290                 295                 300                 


Val Ser Leu Cys Ile Phe Thr Ala Arg Ile Tyr Asp Asp Gln Gly Arg 
305                 310                 315                 320 


Cys Gln Glu Gly Leu Arg Thr Leu Ala Glu Ala Gly Ala Lys Ile Ser 
                325                 330                 335     


Ile Met Thr Tyr Ser Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp 
            340                 345                 350         


His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser 
        355                 360                 365             


Gln Asp Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Glu Asn 
    370                 375                 380                 


<210>  649
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3H__Homo_sapiens__NP_001159474

<400>  649

Met Ala Leu Leu Thr Ala Glu Thr Phe Arg Leu Gln Phe Asn Asn Lys 
1               5                   10                  15      


Arg Arg Leu Arg Arg Pro Tyr Tyr Pro Arg Lys Ala Leu Leu Cys Tyr 
            20                  25                  30          


Gln Leu Thr Pro Gln Asn Gly Ser Thr Pro Thr Arg Gly Tyr Phe Glu 
        35                  40                  45              


Asn Lys Lys Lys Cys His Ala Glu Ile Cys Phe Ile Asn Glu Ile Lys 
    50                  55                  60                  


Ser Met Gly Leu Asp Glu Thr Gln Cys Tyr Gln Val Thr Cys Tyr Leu 
65                  70                  75                  80  


Thr Trp Ser Pro Cys Ser Ser Cys Ala Trp Glu Leu Val Asp Phe Ile 
                85                  90                  95      


Lys Ala His Asp His Leu Asn Leu Gly Ile Phe Ala Ser Arg Leu Tyr 
            100                 105                 110         


Tyr His Trp Cys Lys Pro Gln Gln Lys Gly Leu Arg Leu Leu Cys Gly 
        115                 120                 125             


Ser Gln Val Pro Val Glu Val Met Gly Phe Pro Glu Phe Ala Asp Cys 
    130                 135                 140                 


Trp Glu Asn Phe Val Asp His Glu Lys Pro Leu Ser Phe Asn Pro Tyr 
145                 150                 155                 160 


Lys Met Leu Glu Glu Leu Asp Lys Asn Ser Arg Ala Ile Lys Arg Arg 
                165                 170                 175     


Leu Glu Arg Ile Lys Ser 
            180         


<210>  650
<211>  4563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOB__Homo_sapiens__NP_000375

<400>  650

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala Glu Glu Glu Met Leu 
            20                  25                  30          


Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala Thr Arg Phe Lys His 
        35                  40                  45              


Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala Glu Ser Ser Ser Gly Val 
    50                  55                  60                  


Pro Gly Thr Ala Asp Ser Arg Ser Ala Thr Arg Ile Asn Cys Lys Val 
65                  70                  75                  80  


Glu Leu Glu Val Pro Gln Leu Cys Ser Phe Ile Leu Lys Thr Ser Gln 
                85                  90                  95      


Cys Thr Leu Lys Glu Val Tyr Gly Phe Asn Pro Glu Gly Lys Ala Leu 
            100                 105                 110         


Leu Lys Lys Thr Lys Asn Ser Glu Glu Phe Ala Ala Ala Met Ser Arg 
        115                 120                 125             


Tyr Glu Leu Lys Leu Ala Ile Pro Glu Gly Lys Gln Val Phe Leu Tyr 
    130                 135                 140                 


Pro Glu Lys Asp Glu Pro Thr Tyr Ile Leu Asn Ile Lys Arg Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val 
                165                 170                 175     


Leu Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val 
            180                 185                 190         


Lys Thr Arg Lys Gly Asn Val Ala Thr Glu Ile Ser Thr Glu Arg Asp 
        195                 200                 205             


Leu Gly Gln Cys Asp Arg Phe Lys Pro Ile Arg Thr Gly Ile Ser Pro 
    210                 215                 220                 


Leu Ala Leu Ile Lys Gly Met Thr Arg Pro Leu Ser Thr Leu Ile Ser 
225                 230                 235                 240 


Ser Ser Gln Ser Cys Gln Tyr Thr Leu Asp Ala Lys Arg Lys His Val 
                245                 250                 255     


Ala Glu Ala Ile Cys Lys Glu Gln His Leu Phe Leu Pro Phe Ser Tyr 
            260                 265                 270         


Lys Asn Lys Tyr Gly Met Val Ala Gln Val Thr Gln Thr Leu Lys Leu 
        275                 280                 285             


Glu Asp Thr Pro Lys Ile Asn Ser Arg Phe Phe Gly Glu Gly Thr Lys 
    290                 295                 300                 


Lys Met Gly Leu Ala Phe Glu Ser Thr Lys Ser Thr Ser Pro Pro Lys 
305                 310                 315                 320 


Gln Ala Glu Ala Val Leu Lys Thr Leu Gln Glu Leu Lys Lys Leu Thr 
                325                 330                 335     


Ile Ser Glu Gln Asn Ile Gln Arg Ala Asn Leu Phe Asn Lys Leu Val 
            340                 345                 350         


Thr Glu Leu Arg Gly Leu Ser Asp Glu Ala Val Thr Ser Leu Leu Pro 
        355                 360                 365             


Gln Leu Ile Glu Val Ser Ser Pro Ile Thr Leu Gln Ala Leu Val Gln 
    370                 375                 380                 


Cys Gly Gln Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg 
385                 390                 395                 400 


Val His Ala Asn Pro Leu Leu Ile Asp Val Val Thr Tyr Leu Val Ala 
                405                 410                 415     


Leu Ile Pro Glu Pro Ser Ala Gln Gln Leu Arg Glu Ile Phe Asn Met 
            420                 425                 430         


Ala Arg Asp Gln Arg Ser Arg Ala Thr Leu Tyr Ala Leu Ser His Ala 
        435                 440                 445             


Val Asn Asn Tyr His Lys Thr Asn Pro Thr Gly Thr Gln Glu Leu Leu 
    450                 455                 460                 


Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys Thr Gly 
465                 470                 475                 480 


Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly Asn Met Gly 
                485                 490                 495     


Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser Ser Ile Leu Lys 
            500                 505                 510         


Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile Gln Lys Ala Ala Ile 
        515                 520                 525             


Gln Ala Leu Arg Lys Met Glu Pro Lys Asp Lys Asp Gln Glu Val Leu 
    530                 535                 540                 


Leu Gln Thr Phe Leu Asp Asp Ala Ser Pro Gly Asp Lys Arg Leu Ala 
545                 550                 555                 560 


Ala Tyr Leu Met Leu Met Arg Ser Pro Ser Gln Ala Asp Ile Asn Lys 
                565                 570                 575     


Ile Val Gln Ile Leu Pro Trp Glu Gln Asn Glu Gln Val Lys Asn Phe 
            580                 585                 590         


Val Ala Ser His Ile Ala Asn Ile Leu Asn Ser Glu Glu Leu Asp Ile 
        595                 600                 605             


Gln Asp Leu Lys Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu 
    610                 615                 620                 


Pro Thr Val Met Asp Phe Arg Lys Phe Ser Arg Asn Tyr Gln Leu Tyr 
625                 630                 635                 640 


Lys Ser Val Ser Leu Pro Ser Leu Asp Pro Ala Ser Ala Lys Ile Glu 
                645                 650                 655     


Gly Asn Leu Ile Phe Asp Pro Asn Asn Tyr Leu Pro Lys Glu Ser Met 
            660                 665                 670         


Leu Lys Thr Thr Leu Thr Ala Phe Gly Phe Ala Ser Ala Asp Leu Ile 
        675                 680                 685             


Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala Leu 
    690                 695                 700                 


Phe Gly Lys Gln Gly Phe Phe Pro Asp Ser Val Asn Lys Ala Leu Tyr 
705                 710                 715                 720 


Trp Val Asn Gly Gln Val Pro Asp Gly Val Ser Lys Val Leu Val Asp 
                725                 730                 735     


His Phe Gly Tyr Thr Lys Asp Asp Lys His Glu Gln Asp Met Val Asn 
            740                 745                 750         


Gly Ile Met Leu Ser Val Glu Lys Leu Ile Lys Asp Leu Lys Ser Lys 
        755                 760                 765             


Glu Val Pro Glu Ala Arg Ala Tyr Leu Arg Ile Leu Gly Glu Glu Leu 
    770                 775                 780                 


Gly Phe Ala Ser Leu His Asp Leu Gln Leu Leu Gly Lys Leu Leu Leu 
785                 790                 795                 800 


Met Gly Ala Arg Thr Leu Gln Gly Ile Pro Gln Met Ile Gly Glu Val 
                805                 810                 815     


Ile Arg Lys Gly Ser Lys Asn Asp Phe Phe Leu His Tyr Ile Phe Met 
            820                 825                 830         


Glu Asn Ala Phe Glu Leu Pro Thr Gly Ala Gly Leu Gln Leu Gln Ile 
        835                 840                 845             


Ser Ser Ser Gly Val Ile Ala Pro Gly Ala Lys Ala Gly Val Lys Leu 
    850                 855                 860                 


Glu Val Ala Asn Met Gln Ala Glu Leu Val Ala Lys Pro Ser Val Ser 
865                 870                 875                 880 


Val Glu Phe Val Thr Asn Met Gly Ile Ile Ile Pro Asp Phe Ala Arg 
                885                 890                 895     


Ser Gly Val Gln Met Asn Thr Asn Phe Phe His Glu Ser Gly Leu Glu 
            900                 905                 910         


Ala His Val Ala Leu Lys Ala Gly Lys Leu Lys Phe Ile Ile Pro Ser 
        915                 920                 925             


Pro Lys Arg Pro Val Lys Leu Leu Ser Gly Gly Asn Thr Leu His Leu 
    930                 935                 940                 


Val Ser Thr Thr Lys Thr Glu Val Ile Pro Pro Leu Ile Glu Asn Arg 
945                 950                 955                 960 


Gln Ser Trp Ser Val Cys Lys Gln Val Phe Pro Gly Leu Asn Tyr Cys 
                965                 970                 975     


Thr Ser Gly Ala Tyr Ser Asn Ala Ser Ser Thr Asp Ser Ala Ser Tyr 
            980                 985                 990         


Tyr Pro Leu Thr Gly Asp Thr Arg  Leu Glu Leu Glu Leu  Arg Pro Thr 
        995                 1000                 1005             


Gly Glu  Ile Glu Gln Tyr Ser  Val Ser Ala Thr Tyr  Glu Leu Gln 
    1010                 1015                 1020             


Arg Glu  Asp Arg Ala Leu Val  Asp Thr Leu Lys Phe  Val Thr Gln 
    1025                 1030                 1035             


Ala Glu  Gly Ala Lys Gln Thr  Glu Ala Thr Met Thr  Phe Lys Tyr 
    1040                 1045                 1050             


Asn Arg  Gln Ser Met Thr Leu  Ser Ser Glu Val Gln  Ile Pro Asp 
    1055                 1060                 1065             


Phe Asp  Val Asp Leu Gly Thr  Ile Leu Arg Val Asn  Asp Glu Ser 
    1070                 1075                 1080             


Thr Glu  Gly Lys Thr Ser Tyr  Arg Leu Thr Leu Asp  Ile Gln Asn 
    1085                 1090                 1095             


Lys Lys  Ile Thr Glu Val Ala  Leu Met Gly His Leu  Ser Cys Asp 
    1100                 1105                 1110             


Thr Lys  Glu Glu Arg Lys Ile  Lys Gly Val Ile Ser  Ile Pro Arg 
    1115                 1120                 1125             


Leu Gln  Ala Glu Ala Arg Ser  Glu Ile Leu Ala His  Trp Ser Pro 
    1130                 1135                 1140             


Ala Lys  Leu Leu Leu Gln Met  Asp Ser Ser Ala Thr  Ala Tyr Gly 
    1145                 1150                 1155             


Ser Thr  Val Ser Lys Arg Val  Ala Trp His Tyr Asp  Glu Glu Lys 
    1160                 1165                 1170             


Ile Glu  Phe Glu Trp Asn Thr  Gly Thr Asn Val Asp  Thr Lys Lys 
    1175                 1180                 1185             


Met Thr  Ser Asn Phe Pro Val  Asp Leu Ser Asp Tyr  Pro Lys Ser 
    1190                 1195                 1200             


Leu His  Met Tyr Ala Asn Arg  Leu Leu Asp His Arg  Val Pro Gln 
    1205                 1210                 1215             


Thr Asp  Met Thr Phe Arg His  Val Gly Ser Lys Leu  Ile Val Ala 
    1220                 1225                 1230             


Met Ser  Ser Trp Leu Gln Lys  Ala Ser Gly Ser Leu  Pro Tyr Thr 
    1235                 1240                 1245             


Gln Thr  Leu Gln Asp His Leu  Asn Ser Leu Lys Glu  Phe Asn Leu 
    1250                 1255                 1260             


Gln Asn  Met Gly Leu Pro Asp  Phe His Ile Pro Glu  Asn Leu Phe 
    1265                 1270                 1275             


Leu Lys  Ser Asp Gly Arg Val  Lys Tyr Thr Leu Asn  Lys Asn Ser 
    1280                 1285                 1290             


Leu Lys  Ile Glu Ile Pro Leu  Pro Phe Gly Gly Lys  Ser Ser Arg 
    1295                 1300                 1305             


Asp Leu  Lys Met Leu Glu Thr  Val Arg Thr Pro Ala  Leu His Phe 
    1310                 1315                 1320             


Lys Ser  Val Gly Phe His Leu  Pro Ser Arg Glu Phe  Gln Val Pro 
    1325                 1330                 1335             


Thr Phe  Thr Ile Pro Lys Leu  Tyr Gln Leu Gln Val  Pro Leu Leu 
    1340                 1345                 1350             


Gly Val  Leu Asp Leu Ser Thr  Asn Val Tyr Ser Asn  Leu Tyr Asn 
    1355                 1360                 1365             


Trp Ser  Ala Ser Tyr Ser Gly  Gly Asn Thr Ser Thr  Asp His Phe 
    1370                 1375                 1380             


Ser Leu  Arg Ala Arg Tyr His  Met Lys Ala Asp Ser  Val Val Asp 
    1385                 1390                 1395             


Leu Leu  Ser Tyr Asn Val Gln  Gly Ser Gly Glu Thr  Thr Tyr Asp 
    1400                 1405                 1410             


His Lys  Asn Thr Phe Thr Leu  Ser Cys Asp Gly Ser  Leu Arg His 
    1415                 1420                 1425             


Lys Phe  Leu Asp Ser Asn Ile  Lys Phe Ser His Val  Glu Lys Leu 
    1430                 1435                 1440             


Gly Asn  Asn Pro Val Ser Lys  Gly Leu Leu Ile Phe  Asp Ala Ser 
    1445                 1450                 1455             


Ser Ser  Trp Gly Pro Gln Met  Ser Ala Ser Val His  Leu Asp Ser 
    1460                 1465                 1470             


Lys Lys  Lys Gln His Leu Phe  Val Lys Glu Val Lys  Ile Asp Gly 
    1475                 1480                 1485             


Gln Phe  Arg Val Ser Ser Phe  Tyr Ala Lys Gly Thr  Tyr Gly Leu 
    1490                 1495                 1500             


Ser Cys  Gln Arg Asp Pro Asn  Thr Gly Arg Leu Asn  Gly Glu Ser 
    1505                 1510                 1515             


Asn Leu  Arg Phe Asn Ser Ser  Tyr Leu Gln Gly Thr  Asn Gln Ile 
    1520                 1525                 1530             


Thr Gly  Arg Tyr Glu Asp Gly  Thr Leu Ser Leu Thr  Ser Thr Ser 
    1535                 1540                 1545             


Asp Leu  Gln Ser Gly Ile Ile  Lys Asn Thr Ala Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Glu Asn  Tyr Glu Leu Thr Leu  Lys Ser Asp Thr Asn  Gly Lys Tyr 
    1565                 1570                 1575             


Lys Asn  Phe Ala Thr Ser Asn  Lys Met Asp Met Thr  Phe Ser Lys 
    1580                 1585                 1590             


Gln Asn  Ala Leu Leu Arg Ser  Glu Tyr Gln Ala Asp  Tyr Glu Ser 
    1595                 1600                 1605             


Leu Arg  Phe Phe Ser Leu Leu  Ser Gly Ser Leu Asn  Ser His Gly 
    1610                 1615                 1620             


Leu Glu  Leu Asn Ala Asp Ile  Leu Gly Thr Asp Lys  Ile Asn Ser 
    1625                 1630                 1635             


Gly Ala  His Lys Ala Thr Leu  Arg Ile Gly Gln Asp  Gly Ile Ser 
    1640                 1645                 1650             


Thr Ser  Ala Thr Thr Asn Leu  Lys Cys Ser Leu Leu  Val Leu Glu 
    1655                 1660                 1665             


Asn Glu  Leu Asn Ala Glu Leu  Gly Leu Ser Gly Ala  Ser Met Lys 
    1670                 1675                 1680             


Leu Thr  Thr Asn Gly Arg Phe  Arg Glu His Asn Ala  Lys Phe Ser 
    1685                 1690                 1695             


Leu Asp  Gly Lys Ala Ala Leu  Thr Glu Leu Ser Leu  Gly Ser Ala 
    1700                 1705                 1710             


Tyr Gln  Ala Met Ile Leu Gly  Val Asp Ser Lys Asn  Ile Phe Asn 
    1715                 1720                 1725             


Phe Lys  Val Ser Gln Glu Gly  Leu Lys Leu Ser Asn  Asp Met Met 
    1730                 1735                 1740             


Gly Ser  Tyr Ala Glu Met Lys  Phe Asp His Thr Asn  Ser Leu Asn 
    1745                 1750                 1755             


Ile Ala  Gly Leu Ser Leu Asp  Phe Ser Ser Lys Leu  Asp Asn Ile 
    1760                 1765                 1770             


Tyr Ser  Ser Asp Lys Phe Tyr  Lys Gln Thr Val Asn  Leu Gln Leu 
    1775                 1780                 1785             


Gln Pro  Tyr Ser Leu Val Thr  Thr Leu Asn Ser Asp  Leu Lys Tyr 
    1790                 1795                 1800             


Asn Ala  Leu Asp Leu Thr Asn  Asn Gly Lys Leu Arg  Leu Glu Pro 
    1805                 1810                 1815             


Leu Lys  Leu His Val Ala Gly  Asn Leu Lys Gly Ala  Tyr Gln Asn 
    1820                 1825                 1830             


Asn Glu  Ile Lys His Ile Tyr  Ala Ile Ser Ser Ala  Ala Leu Ser 
    1835                 1840                 1845             


Ala Ser  Tyr Lys Ala Asp Thr  Val Ala Lys Val Gln  Gly Val Glu 
    1850                 1855                 1860             


Phe Ser  His Arg Leu Asn Thr  Asp Ile Ala Gly Leu  Ala Ser Ala 
    1865                 1870                 1875             


Ile Asp  Met Ser Thr Asn Tyr  Asn Ser Asp Ser Leu  His Phe Ser 
    1880                 1885                 1890             


Asn Val  Phe Arg Ser Val Met  Ala Pro Phe Thr Met  Thr Ile Asp 
    1895                 1900                 1905             


Ala His  Thr Asn Gly Asn Gly  Lys Leu Ala Leu Trp  Gly Glu His 
    1910                 1915                 1920             


Thr Gly  Gln Leu Tyr Ser Lys  Phe Leu Leu Lys Ala  Glu Pro Leu 
    1925                 1930                 1935             


Ala Phe  Thr Phe Ser His Asp  Tyr Lys Gly Ser Thr  Ser His His 
    1940                 1945                 1950             


Leu Val  Ser Arg Lys Ser Ile  Ser Ala Ala Leu Glu  His Lys Val 
    1955                 1960                 1965             


Ser Ala  Leu Leu Thr Pro Ala  Glu Gln Thr Gly Thr  Trp Lys Leu 
    1970                 1975                 1980             


Lys Thr  Gln Phe Asn Asn Asn  Glu Tyr Ser Gln Asp  Leu Asp Ala 
    1985                 1990                 1995             


Tyr Asn  Thr Lys Asp Lys Ile  Gly Val Glu Leu Thr  Gly Arg Thr 
    2000                 2005                 2010             


Leu Ala  Asp Leu Thr Leu Leu  Asp Ser Pro Ile Lys  Val Pro Leu 
    2015                 2020                 2025             


Leu Leu  Ser Glu Pro Ile Asn  Ile Ile Asp Ala Leu  Glu Met Arg 
    2030                 2035                 2040             


Asp Ala  Val Glu Lys Pro Gln  Glu Phe Thr Ile Val  Ala Phe Val 
    2045                 2050                 2055             


Lys Tyr  Asp Lys Asn Gln Asp  Val His Ser Ile Asn  Leu Pro Phe 
    2060                 2065                 2070             


Phe Glu  Thr Leu Gln Glu Tyr  Phe Glu Arg Asn Arg  Gln Thr Ile 
    2075                 2080                 2085             


Ile Val  Val Leu Glu Asn Val  Gln Arg Asn Leu Lys  His Ile Asn 
    2090                 2095                 2100             


Ile Asp  Gln Phe Val Arg Lys  Tyr Arg Ala Ala Leu  Gly Lys Leu 
    2105                 2110                 2115             


Pro Gln  Gln Ala Asn Asp Tyr  Leu Asn Ser Phe Asn  Trp Glu Arg 
    2120                 2125                 2130             


Gln Val  Ser His Ala Lys Glu  Lys Leu Thr Ala Leu  Thr Lys Lys 
    2135                 2140                 2145             


Tyr Arg  Ile Thr Glu Asn Asp  Ile Gln Ile Ala Leu  Asp Asp Ala 
    2150                 2155                 2160             


Lys Ile  Asn Phe Asn Glu Lys  Leu Ser Gln Leu Gln  Thr Tyr Met 
    2165                 2170                 2175             


Ile Gln  Phe Asp Gln Tyr Ile  Lys Asp Ser Tyr Asp  Leu His Asp 
    2180                 2185                 2190             


Leu Lys  Ile Ala Ile Ala Asn  Ile Ile Asp Glu Ile  Ile Glu Lys 
    2195                 2200                 2205             


Leu Lys  Ser Leu Asp Glu His  Tyr His Ile Arg Val  Asn Leu Val 
    2210                 2215                 2220             


Lys Thr  Ile His Asp Leu His  Leu Phe Ile Glu Asn  Ile Asp Phe 
    2225                 2230                 2235             


Asn Lys  Ser Gly Ser Ser Thr  Ala Ser Trp Ile Gln  Asn Val Asp 
    2240                 2245                 2250             


Thr Lys  Tyr Gln Ile Arg Ile  Gln Ile Gln Glu Lys  Leu Gln Gln 
    2255                 2260                 2265             


Leu Lys  Arg His Ile Gln Asn  Ile Asp Ile Gln His  Leu Ala Gly 
    2270                 2275                 2280             


Lys Leu  Lys Gln His Ile Glu  Ala Ile Asp Val Arg  Val Leu Leu 
    2285                 2290                 2295             


Asp Gln  Leu Gly Thr Thr Ile  Ser Phe Glu Arg Ile  Asn Asp Val 
    2300                 2305                 2310             


Leu Glu  His Val Lys His Phe  Val Ile Asn Leu Ile  Gly Asp Phe 
    2315                 2320                 2325             


Glu Val  Ala Glu Lys Ile Asn  Ala Phe Arg Ala Lys  Val His Glu 
    2330                 2335                 2340             


Leu Ile  Glu Arg Tyr Glu Val  Asp Gln Gln Ile Gln  Val Leu Met 
    2345                 2350                 2355             


Asp Lys  Leu Val Glu Leu Ala  His Gln Tyr Lys Leu  Lys Glu Thr 
    2360                 2365                 2370             


Ile Gln  Lys Leu Ser Asn Val  Leu Gln Gln Val Lys  Ile Lys Asp 
    2375                 2380                 2385             


Tyr Phe  Glu Lys Leu Val Gly  Phe Ile Asp Asp Ala  Val Lys Lys 
    2390                 2395                 2400             


Leu Asn  Glu Leu Ser Phe Lys  Thr Phe Ile Glu Asp  Val Asn Lys 
    2405                 2410                 2415             


Phe Leu  Asp Met Leu Ile Lys  Lys Leu Lys Ser Phe  Asp Tyr His 
    2420                 2425                 2430             


Gln Phe  Val Asp Glu Thr Asn  Asp Lys Ile Arg Glu  Val Thr Gln 
    2435                 2440                 2445             


Arg Leu  Asn Gly Glu Ile Gln  Ala Leu Glu Leu Pro  Gln Lys Ala 
    2450                 2455                 2460             


Glu Ala  Leu Lys Leu Phe Leu  Glu Glu Thr Lys Ala  Thr Val Ala 
    2465                 2470                 2475             


Val Tyr  Leu Glu Ser Leu Gln  Asp Thr Lys Ile Thr  Leu Ile Ile 
    2480                 2485                 2490             


Asn Trp  Leu Gln Glu Ala Leu  Ser Ser Ala Ser Leu  Ala His Met 
    2495                 2500                 2505             


Lys Ala  Lys Phe Arg Glu Thr  Leu Glu Asp Thr Arg  Asp Arg Met 
    2510                 2515                 2520             


Tyr Gln  Met Asp Ile Gln Gln  Glu Leu Gln Arg Tyr  Leu Ser Leu 
    2525                 2530                 2535             


Val Gly  Gln Val Tyr Ser Thr  Leu Val Thr Tyr Ile  Ser Asp Trp 
    2540                 2545                 2550             


Trp Thr  Leu Ala Ala Lys Asn  Leu Thr Asp Phe Ala  Glu Gln Tyr 
    2555                 2560                 2565             


Ser Ile  Gln Asp Trp Ala Lys  Arg Met Lys Ala Leu  Val Glu Gln 
    2570                 2575                 2580             


Gly Phe  Thr Val Pro Glu Ile  Lys Thr Ile Leu Gly  Thr Met Pro 
    2585                 2590                 2595             


Ala Phe  Glu Val Ser Leu Gln  Ala Leu Gln Lys Ala  Thr Phe Gln 
    2600                 2605                 2610             


Thr Pro  Asp Phe Ile Val Pro  Leu Thr Asp Leu Arg  Ile Pro Ser 
    2615                 2620                 2625             


Val Gln  Ile Asn Phe Lys Asp  Leu Lys Asn Ile Lys  Ile Pro Ser 
    2630                 2635                 2640             


Arg Phe  Ser Thr Pro Glu Phe  Thr Ile Leu Asn Thr  Phe His Ile 
    2645                 2650                 2655             


Pro Ser  Phe Thr Ile Asp Phe  Val Glu Met Lys Val  Lys Ile Ile 
    2660                 2665                 2670             


Arg Thr  Ile Asp Gln Met Leu  Asn Ser Glu Leu Gln  Trp Pro Val 
    2675                 2680                 2685             


Pro Asp  Ile Tyr Leu Arg Asp  Leu Lys Val Glu Asp  Ile Pro Leu 
    2690                 2695                 2700             


Ala Arg  Ile Thr Leu Pro Asp  Phe Arg Leu Pro Glu  Ile Ala Ile 
    2705                 2710                 2715             


Pro Glu  Phe Ile Ile Pro Thr  Leu Asn Leu Asn Asp  Phe Gln Val 
    2720                 2725                 2730             


Pro Asp  Leu His Ile Pro Glu  Phe Gln Leu Pro His  Ile Ser His 
    2735                 2740                 2745             


Thr Ile  Glu Val Pro Thr Phe  Gly Lys Leu Tyr Ser  Ile Leu Lys 
    2750                 2755                 2760             


Ile Gln  Ser Pro Leu Phe Thr  Leu Asp Ala Asn Ala  Asp Ile Gly 
    2765                 2770                 2775             


Asn Gly  Thr Thr Ser Ala Asn  Glu Ala Gly Ile Ala  Ala Ser Ile 
    2780                 2785                 2790             


Thr Ala  Lys Gly Glu Ser Lys  Leu Glu Val Leu Asn  Phe Asp Phe 
    2795                 2800                 2805             


Gln Ala  Asn Ala Gln Leu Ser  Asn Pro Lys Ile Asn  Pro Leu Ala 
    2810                 2815                 2820             


Leu Lys  Glu Ser Val Lys Phe  Ser Ser Lys Tyr Leu  Arg Thr Glu 
    2825                 2830                 2835             


His Gly  Ser Glu Met Leu Phe  Phe Gly Asn Ala Ile  Glu Gly Lys 
    2840                 2845                 2850             


Ser Asn  Thr Val Ala Ser Leu  His Thr Glu Lys Asn  Thr Leu Glu 
    2855                 2860                 2865             


Leu Ser  Asn Gly Val Ile Val  Lys Ile Asn Asn Gln  Leu Thr Leu 
    2870                 2875                 2880             


Asp Ser  Asn Thr Lys Tyr Phe  His Lys Leu Asn Ile  Pro Lys Leu 
    2885                 2890                 2895             


Asp Phe  Ser Ser Gln Ala Asp  Leu Arg Asn Glu Ile  Lys Thr Leu 
    2900                 2905                 2910             


Leu Lys  Ala Gly His Ile Ala  Trp Thr Ser Ser Gly  Lys Gly Ser 
    2915                 2920                 2925             


Trp Lys  Trp Ala Cys Pro Arg  Phe Ser Asp Glu Gly  Thr His Glu 
    2930                 2935                 2940             


Ser Gln  Ile Ser Phe Thr Ile  Glu Gly Pro Leu Thr  Ser Phe Gly 
    2945                 2950                 2955             


Leu Ser  Asn Lys Ile Asn Ser  Lys His Leu Arg Val  Asn Gln Asn 
    2960                 2965                 2970             


Leu Val  Tyr Glu Ser Gly Ser  Leu Asn Phe Ser Lys  Leu Glu Ile 
    2975                 2980                 2985             


Gln Ser  Gln Val Asp Ser Gln  His Val Gly His Ser  Val Leu Thr 
    2990                 2995                 3000             


Ala Lys  Gly Met Ala Leu Phe  Gly Glu Gly Lys Ala  Glu Phe Thr 
    3005                 3010                 3015             


Gly Arg  His Asp Ala His Leu  Asn Gly Lys Val Ile  Gly Thr Leu 
    3020                 3025                 3030             


Lys Asn  Ser Leu Phe Phe Ser  Ala Gln Pro Phe Glu  Ile Thr Ala 
    3035                 3040                 3045             


Ser Thr  Asn Asn Glu Gly Asn  Leu Lys Val Arg Phe  Pro Leu Arg 
    3050                 3055                 3060             


Leu Thr  Gly Lys Ile Asp Phe  Leu Asn Asn Tyr Ala  Leu Phe Leu 
    3065                 3070                 3075             


Ser Pro  Ser Ala Gln Gln Ala  Ser Trp Gln Val Ser  Ala Arg Phe 
    3080                 3085                 3090             


Asn Gln  Tyr Lys Tyr Asn Gln  Asn Phe Ser Ala Gly  Asn Asn Glu 
    3095                 3100                 3105             


Asn Ile  Met Glu Ala His Val  Gly Ile Asn Gly Glu  Ala Asn Leu 
    3110                 3115                 3120             


Asp Phe  Leu Asn Ile Pro Leu  Thr Ile Pro Glu Met  Arg Leu Pro 
    3125                 3130                 3135             


Tyr Thr  Ile Ile Thr Thr Pro  Pro Leu Lys Asp Phe  Ser Leu Trp 
    3140                 3145                 3150             


Glu Lys  Thr Gly Leu Lys Glu  Phe Leu Lys Thr Thr  Lys Gln Ser 
    3155                 3160                 3165             


Phe Asp  Leu Ser Val Lys Ala  Gln Tyr Lys Lys Asn  Lys His Arg 
    3170                 3175                 3180             


His Ser  Ile Thr Asn Pro Leu  Ala Val Leu Cys Glu  Phe Ile Ser 
    3185                 3190                 3195             


Gln Ser  Ile Lys Ser Phe Asp  Arg His Phe Glu Lys  Asn Arg Asn 
    3200                 3205                 3210             


Asn Ala  Leu Asp Phe Val Thr  Lys Ser Tyr Asn Glu  Thr Lys Ile 
    3215                 3220                 3225             


Lys Phe  Asp Lys Tyr Lys Ala  Glu Lys Ser His Asp  Glu Leu Pro 
    3230                 3235                 3240             


Arg Thr  Phe Gln Ile Pro Gly  Tyr Thr Val Pro Val  Val Asn Val 
    3245                 3250                 3255             


Glu Val  Ser Pro Phe Thr Ile  Glu Met Ser Ala Phe  Gly Tyr Val 
    3260                 3265                 3270             


Phe Pro  Lys Ala Val Ser Met  Pro Ser Phe Ser Ile  Leu Gly Ser 
    3275                 3280                 3285             


Asp Val  Arg Val Pro Ser Tyr  Thr Leu Ile Leu Pro  Ser Leu Glu 
    3290                 3295                 3300             


Leu Pro  Val Leu His Val Pro  Arg Asn Leu Lys Leu  Ser Leu Pro 
    3305                 3310                 3315             


Asp Phe  Lys Glu Leu Cys Thr  Ile Ser His Ile Phe  Ile Pro Ala 
    3320                 3325                 3330             


Met Gly  Asn Ile Thr Tyr Asp  Phe Ser Phe Lys Ser  Ser Val Ile 
    3335                 3340                 3345             


Thr Leu  Asn Thr Asn Ala Glu  Leu Phe Asn Gln Ser  Asp Ile Val 
    3350                 3355                 3360             


Ala His  Leu Leu Ser Ser Ser  Ser Ser Val Ile Asp  Ala Leu Gln 
    3365                 3370                 3375             


Tyr Lys  Leu Glu Gly Thr Thr  Arg Leu Thr Arg Lys  Arg Gly Leu 
    3380                 3385                 3390             


Lys Leu  Ala Thr Ala Leu Ser  Leu Ser Asn Lys Phe  Val Glu Gly 
    3395                 3400                 3405             


Ser His  Asn Ser Thr Val Ser  Leu Thr Thr Lys Asn  Met Glu Val 
    3410                 3415                 3420             


Ser Val  Ala Thr Thr Thr Lys  Ala Gln Ile Pro Ile  Leu Arg Met 
    3425                 3430                 3435             


Asn Phe  Lys Gln Glu Leu Asn  Gly Asn Thr Lys Ser  Lys Pro Thr 
    3440                 3445                 3450             


Val Ser  Ser Ser Met Glu Phe  Lys Tyr Asp Phe Asn  Ser Ser Met 
    3455                 3460                 3465             


Leu Tyr  Ser Thr Ala Lys Gly  Ala Val Asp His Lys  Leu Ser Leu 
    3470                 3475                 3480             


Glu Ser  Leu Thr Ser Tyr Phe  Ser Ile Glu Ser Ser  Thr Lys Gly 
    3485                 3490                 3495             


Asp Val  Lys Gly Ser Val Leu  Ser Arg Glu Tyr Ser  Gly Thr Ile 
    3500                 3505                 3510             


Ala Ser  Glu Ala Asn Thr Tyr  Leu Asn Ser Lys Ser  Thr Arg Ser 
    3515                 3520                 3525             


Ser Val  Lys Leu Gln Gly Thr  Ser Lys Ile Asp Asp  Ile Trp Asn 
    3530                 3535                 3540             


Leu Glu  Val Lys Glu Asn Phe  Ala Gly Glu Ala Thr  Leu Gln Arg 
    3545                 3550                 3555             


Ile Tyr  Ser Leu Trp Glu His  Ser Thr Lys Asn His  Leu Gln Leu 
    3560                 3565                 3570             


Glu Gly  Leu Phe Phe Thr Asn  Gly Glu His Thr Ser  Lys Ala Thr 
    3575                 3580                 3585             


Leu Glu  Leu Ser Pro Trp Gln  Met Ser Ala Leu Val  Gln Val His 
    3590                 3595                 3600             


Ala Ser  Gln Pro Ser Ser Phe  His Asp Phe Pro Asp  Leu Gly Gln 
    3605                 3610                 3615             


Glu Val  Ala Leu Asn Ala Asn  Thr Lys Asn Gln Lys  Ile Arg Trp 
    3620                 3625                 3630             


Lys Asn  Glu Val Arg Ile His  Ser Gly Ser Phe Gln  Ser Gln Val 
    3635                 3640                 3645             


Glu Leu  Ser Asn Asp Gln Glu  Lys Ala His Leu Asp  Ile Ala Gly 
    3650                 3655                 3660             


Ser Leu  Glu Gly His Leu Arg  Phe Leu Lys Asn Ile  Ile Leu Pro 
    3665                 3670                 3675             


Val Tyr  Asp Lys Ser Leu Trp  Asp Phe Leu Lys Leu  Asp Val Thr 
    3680                 3685                 3690             


Thr Ser  Ile Gly Arg Arg Gln  His Leu Arg Val Ser  Thr Ala Phe 
    3695                 3700                 3705             


Val Tyr  Thr Lys Asn Pro Asn  Gly Tyr Ser Phe Ser  Ile Pro Val 
    3710                 3715                 3720             


Lys Val  Leu Ala Asp Lys Phe  Ile Ile Pro Gly Leu  Lys Leu Asn 
    3725                 3730                 3735             


Asp Leu  Asn Ser Val Leu Val  Met Pro Thr Phe His  Val Pro Phe 
    3740                 3745                 3750             


Thr Asp  Leu Gln Val Pro Ser  Cys Lys Leu Asp Phe  Arg Glu Ile 
    3755                 3760                 3765             


Gln Ile  Tyr Lys Lys Leu Arg  Thr Ser Ser Phe Ala  Leu Asn Leu 
    3770                 3775                 3780             


Pro Thr  Leu Pro Glu Val Lys  Phe Pro Glu Val Asp  Val Leu Thr 
    3785                 3790                 3795             


Lys Tyr  Ser Gln Pro Glu Asp  Ser Leu Ile Pro Phe  Phe Glu Ile 
    3800                 3805                 3810             


Thr Val  Pro Glu Ser Gln Leu  Thr Val Ser Gln Phe  Thr Leu Pro 
    3815                 3820                 3825             


Lys Ser  Val Ser Asp Gly Ile  Ala Ala Leu Asp Leu  Asn Ala Val 
    3830                 3835                 3840             


Ala Asn  Lys Ile Ala Asp Phe  Glu Leu Pro Thr Ile  Ile Val Pro 
    3845                 3850                 3855             


Glu Gln  Thr Ile Glu Ile Pro  Ser Ile Lys Phe Ser  Val Pro Ala 
    3860                 3865                 3870             


Gly Ile  Val Ile Pro Ser Phe  Gln Ala Leu Thr Ala  Arg Phe Glu 
    3875                 3880                 3885             


Val Asp  Ser Pro Val Tyr Asn  Ala Thr Trp Ser Ala  Ser Leu Lys 
    3890                 3895                 3900             


Asn Lys  Ala Asp Tyr Val Glu  Thr Val Leu Asp Ser  Thr Cys Ser 
    3905                 3910                 3915             


Ser Thr  Val Gln Phe Leu Glu  Tyr Glu Leu Asn Val  Leu Gly Thr 
    3920                 3925                 3930             


His Lys  Ile Glu Asp Gly Thr  Leu Ala Ser Lys Thr  Lys Gly Thr 
    3935                 3940                 3945             


Phe Ala  His Arg Asp Phe Ser  Ala Glu Tyr Glu Glu  Asp Gly Lys 
    3950                 3955                 3960             


Tyr Glu  Gly Leu Gln Glu Trp  Glu Gly Lys Ala His  Leu Asn Ile 
    3965                 3970                 3975             


Lys Ser  Pro Ala Phe Thr Asp  Leu His Leu Arg Tyr  Gln Lys Asp 
    3980                 3985                 3990             


Lys Lys  Gly Ile Ser Thr Ser  Ala Ala Ser Pro Ala  Val Gly Thr 
    3995                 4000                 4005             


Val Gly  Met Asp Met Asp Glu  Asp Asp Asp Phe Ser  Lys Trp Asn 
    4010                 4015                 4020             


Phe Tyr  Tyr Ser Pro Gln Ser  Ser Pro Asp Lys Lys  Leu Thr Ile 
    4025                 4030                 4035             


Phe Lys  Thr Glu Leu Arg Val  Arg Glu Ser Asp Glu  Glu Thr Gln 
    4040                 4045                 4050             


Ile Lys  Val Asn Trp Glu Glu  Glu Ala Ala Ser Gly  Leu Leu Thr 
    4055                 4060                 4065             


Ser Leu  Lys Asp Asn Val Pro  Lys Ala Thr Gly Val  Leu Tyr Asp 
    4070                 4075                 4080             


Tyr Val  Asn Lys Tyr His Trp  Glu His Thr Gly Leu  Thr Leu Arg 
    4085                 4090                 4095             


Glu Val  Ser Ser Lys Leu Arg  Arg Asn Leu Gln Asn  Asn Ala Glu 
    4100                 4105                 4110             


Trp Val  Tyr Gln Gly Ala Ile  Arg Gln Ile Asp Asp  Ile Asp Val 
    4115                 4120                 4125             


Arg Phe  Gln Lys Ala Ala Ser  Gly Thr Thr Gly Thr  Tyr Gln Glu 
    4130                 4135                 4140             


Trp Lys  Asp Lys Ala Gln Asn  Leu Tyr Gln Glu Leu  Leu Thr Gln 
    4145                 4150                 4155             


Glu Gly  Gln Ala Ser Phe Gln  Gly Leu Lys Asp Asn  Val Phe Asp 
    4160                 4165                 4170             


Gly Leu  Val Arg Val Thr Gln  Glu Phe His Met Lys  Val Lys His 
    4175                 4180                 4185             


Leu Ile  Asp Ser Leu Ile Asp  Phe Leu Asn Phe Pro  Arg Phe Gln 
    4190                 4195                 4200             


Phe Pro  Gly Lys Pro Gly Ile  Tyr Thr Arg Glu Glu  Leu Cys Thr 
    4205                 4210                 4215             


Met Phe  Ile Arg Glu Val Gly  Thr Val Leu Ser Gln  Val Tyr Ser 
    4220                 4225                 4230             


Lys Val  His Asn Gly Ser Glu  Ile Leu Phe Ser Tyr  Phe Gln Asp 
    4235                 4240                 4245             


Leu Val  Ile Thr Leu Pro Phe  Glu Leu Arg Lys His  Lys Leu Ile 
    4250                 4255                 4260             


Asp Val  Ile Ser Met Tyr Arg  Glu Leu Leu Lys Asp  Leu Ser Lys 
    4265                 4270                 4275             


Glu Ala  Gln Glu Val Phe Lys  Ala Ile Gln Ser Leu  Lys Thr Thr 
    4280                 4285                 4290             


Glu Val  Leu Arg Asn Leu Gln  Asp Leu Leu Gln Phe  Ile Phe Gln 
    4295                 4300                 4305             


Leu Ile  Glu Asp Asn Ile Lys  Gln Leu Lys Glu Met  Lys Phe Thr 
    4310                 4315                 4320             


Tyr Leu  Ile Asn Tyr Ile Gln  Asp Glu Ile Asn Thr  Ile Phe Ser 
    4325                 4330                 4335             


Asp Tyr  Ile Pro Tyr Val Phe  Lys Leu Leu Lys Glu  Asn Leu Cys 
    4340                 4345                 4350             


Leu Asn  Leu His Lys Phe Asn  Glu Phe Ile Gln Asn  Glu Leu Gln 
    4355                 4360                 4365             


Glu Ala  Ser Gln Glu Leu Gln  Gln Ile His Gln Tyr  Ile Met Ala 
    4370                 4375                 4380             


Leu Arg  Glu Glu Tyr Phe Asp  Pro Ser Ile Val Gly  Trp Thr Val 
    4385                 4390                 4395             


Lys Tyr  Tyr Glu Leu Glu Glu  Lys Ile Val Ser Leu  Ile Lys Asn 
    4400                 4405                 4410             


Leu Leu  Val Ala Leu Lys Asp  Phe His Ser Glu Tyr  Ile Val Ser 
    4415                 4420                 4425             


Ala Ser  Asn Phe Thr Ser Gln  Leu Ser Ser Gln Val  Glu Gln Phe 
    4430                 4435                 4440             


Leu His  Arg Asn Ile Gln Glu  Tyr Leu Ser Ile Leu  Thr Asp Pro 
    4445                 4450                 4455             


Asp Gly  Lys Gly Lys Glu Lys  Ile Ala Glu Leu Ser  Ala Thr Ala 
    4460                 4465                 4470             


Gln Glu  Ile Ile Lys Ser Gln  Ala Ile Ala Thr Lys  Lys Ile Ile 
    4475                 4480                 4485             


Ser Asp  Tyr His Gln Gln Phe  Arg Tyr Lys Leu Gln  Asp Phe Ser 
    4490                 4495                 4500             


Asp Gln  Leu Ser Asp Tyr Tyr  Glu Lys Phe Ile Ala  Glu Ser Lys 
    4505                 4510                 4515             


Arg Leu  Ile Asp Leu Ser Ile  Gln Asn Tyr His Thr  Phe Leu Ile 
    4520                 4525                 4530             


Tyr Ile  Thr Glu Leu Leu Lys  Lys Leu Gln Ser Thr  Thr Val Met 
    4535                 4540                 4545             


Asn Pro  Tyr Met Lys Leu Ala  Pro Gly Glu Leu Thr  Ile Ile Leu 
    4550                 4555                 4560             


<210>  651
<211>  1097
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBR__Homo_sapiens__NP_061160

<400>  651

Met Asp Phe Leu Arg Leu Tyr Leu Pro Gly Leu His Gln Ala Leu Arg 
1               5                   10                  15      


Gly Ala Leu Asp Ser Leu Gly Thr Phe Val Ser Tyr Leu Leu Gly Asp 
            20                  25                  30          


Ala Val Pro Thr Val Glu Arg Glu Ala Gln Ala Ala Glu Glu Leu Gly 
        35                  40                  45              


Val Val Ala Val Gly Lys Thr Gly Lys Ile Val Glu Glu Glu Ala Gln 
    50                  55                  60                  


Glu Asp Leu Glu Gly Leu Arg Gly Ser Gln Asn Glu Gly Ala Gly Arg 
65                  70                  75                  80  


Leu Arg Gly Pro Gly Asp Asp Arg Arg His Glu Val Gly Ser Ser Ala 
                85                  90                  95      


Val Glu Gln Thr Trp Gly Trp Gly Asp Gly Ser Ser His Gly Ser Gln 
            100                 105                 110         


Ala Glu Arg Gln Asp Ser Gly Ala Gly Glu Thr Ala Lys Ala Ala Arg 
        115                 120                 125             


Cys Gln Glu Pro Ser Ala His Leu Glu Ala Arg Lys Lys Ser Lys Ala 
    130                 135                 140                 


Gly Ser Gly Ala Cys Gln Asp Arg Ser Gly Gln Ala Gln Glu Arg Gln 
145                 150                 155                 160 


Glu Ser His Glu Gln Glu Val Asn Arg Glu Glu Arg Leu Arg Ser Trp 
                165                 170                 175     


Glu Gln Glu Glu Glu Glu Glu Glu Val Arg Ala Arg Glu Pro Gly Met 
            180                 185                 190         


Ala Arg Gly Ala Glu Ser Glu Trp Thr Trp His Gly Glu Thr Glu Gly 
        195                 200                 205             


Lys Ala Gly Ala Val Gly Pro Lys Ala Ala Gly Asp Asn Arg Glu Met 
    210                 215                 220                 


Glu Gln Gly Val Arg Glu Ala Asp Ala Gly Glu Thr Glu Glu Pro Gly 
225                 230                 235                 240 


Ala Glu Gly Ala Gly Lys Gly Glu Glu Val Val Val Val Glu Lys Ala 
                245                 250                 255     


Cys Glu Ser Thr Arg Ala Trp Gly Thr Trp Gly Pro Gly Ala Glu Pro 
            260                 265                 270         


Glu Asp Trp Gly Ile Leu Gly Arg Glu Glu Ala Arg Thr Thr Pro Gly 
        275                 280                 285             


Arg Glu Glu Ala Arg Ala Ile Leu Asp Gly Glu Glu Ala Arg Thr Ile 
    290                 295                 300                 


Ser Gly Gly Glu Glu Ala Glu Thr Ala Ser Gly Gly Glu Glu Ala Glu 
305                 310                 315                 320 


Thr Ala Ser Gly Gly Glu Glu Ala Gly Thr Ala Ser Gly Gly Glu Glu 
                325                 330                 335     


Ala Gly Ile Ala Ser Gly Gly Glu Ala Gly Thr Ala Ser Gly Gly Glu 
            340                 345                 350         


Glu Ala Gly Thr Ala Ser Gly Gly Glu Glu Ala Gly Thr Ala Ser Gly 
        355                 360                 365             


Gly Asp Glu Ala Trp Thr Thr Ser Gly Lys Glu Glu Ala Asp Leu Leu 
    370                 375                 380                 


Gly Val Arg Gln Thr Glu Tyr Gly Ala Val Pro Gly Glu Arg Leu Leu 
385                 390                 395                 400 


Glu Ala Thr Gly Lys Val Trp Val Leu Glu Glu Glu Gly Asp Glu Glu 
                405                 410                 415     


Arg Glu Ala Glu Val Ser Pro Phe Pro Lys Gln Pro Gln Val Leu Gly 
            420                 425                 430         


Thr Glu Arg Thr Glu Glu Ala Ala Glu Ser Gln Thr Ala Gly Arg Glu 
        435                 440                 445             


Ala Val Gly Gly Gln Glu Ala Gly Glu Ser Phe Glu Gly Gln Val Asp 
    450                 455                 460                 


Leu Arg Gly Lys Glu Ala Glu Met Arg Gln Asp Leu Gly Ile Arg Ala 
465                 470                 475                 480 


Asp Arg Ala Arg Met Glu Glu Leu Val Gln Ala Glu Glu Ala Gln Glu 
                485                 490                 495     


Glu Arg Gly Ser Ser Arg Asp Pro Val Ala Glu Leu Pro Ser Asp Gly 
            500                 505                 510         


Glu Ala Glu Gly Thr Ala Asp Leu Glu Ala Thr Pro Glu Ala Arg Pro 
        515                 520                 525             


Glu Glu Glu Leu Thr Gly Glu Glu Ser Glu Ala Ala Gln Thr Ser Cys 
    530                 535                 540                 


Gly Leu Leu Gly Val Glu Trp Gly Gly Leu Thr His Ser Val Thr Lys 
545                 550                 555                 560 


Gly Gln Gly Pro Glu Leu Met Gly Gly Ala Gln Thr Pro Thr Lys Gln 
                565                 570                 575     


Pro Glu Glu Arg Glu Ala Gly Glu Val Glu Leu Met Gly Val Leu Ala 
            580                 585                 590         


Leu Ser Lys Glu Glu Gln Glu Arg Ser Leu Glu Ala Gly Pro Arg His 
        595                 600                 605             


Ala Gly Ser Val Lys Pro Glu Ala Ser Glu Ala Phe Pro Gly Ala Trp 
    610                 615                 620                 


Glu Asn Arg Thr Arg Lys Asp Met Glu Arg Gly Asn Thr Gln Glu Asp 
625                 630                 635                 640 


Ala Ala Asp Gly Glu Gln Arg Glu Glu Glu Glu Thr Ala Gly Gly Gln 
                645                 650                 655     


Thr Leu Ala Ala Glu Ala Glu Gly Asp Arg Glu Ser Glu Leu Ser Glu 
            660                 665                 670         


Val Pro Glu Ala Gly Gly Glu Gly Leu Thr Thr Gln Asp Ala Gly Cys 
        675                 680                 685             


Gly Thr Glu Glu Gly Glu Ala Ser Val Ser Glu Asn Gln Glu Leu Asp 
    690                 695                 700                 


Gly Ser Thr Gly Ala Asp Ala Gly Pro Cys Pro Ser Leu Gly Glu Ala 
705                 710                 715                 720 


Tyr Ala Arg Glu Thr Glu Asp Glu Glu Ala Glu Ala Asp Arg Thr Ser 
                725                 730                 735     


Arg Arg Gly Trp Arg Leu Gln Ala Val Ala Val Gly Leu Pro Asp Arg 
            740                 745                 750         


Glu Asp Ala Gln Thr Gly Ser Val Ala Ala Gly Ile Met Gly Gly Asp 
        755                 760                 765             


Val Val Pro His Ile Ser Ala Ala Gly Ala Gly Glu Ala Leu Glu Gly 
    770                 775                 780                 


Val Leu Gly Gln Gly Trp Asp Ser Lys Glu Lys Glu Glu Ala Ala Ala 
785                 790                 795                 800 


Gly Glu His Ala Gly Gly Gln Glu Phe Gly Leu Glu Gly Ser Ala Glu 
                805                 810                 815     


Glu Glu Val Thr Gly Arg Gly Ser Gln Val Glu Ala Phe Glu Ser Arg 
            820                 825                 830         


Glu Gly Gly Pro Trp Gly Gly Arg Val Glu Ala Glu Glu Ser Ala Gly 
        835                 840                 845             


Ala Glu Asp Ser Cys Gly Leu Asp Pro Ala Gly Ser Gln Thr Ala Arg 
    850                 855                 860                 


Ala Glu Gly Met Gly Ala Met Val Glu Ala Gly Gly Leu Leu Glu Lys 
865                 870                 875                 880 


Trp Thr Leu Leu Glu Glu Glu Ala Val Gly Trp Gln Glu Arg Glu Gln 
                885                 890                 895     


Arg Glu Asp Ser Glu Gly Arg Cys Gly Asp Tyr His Pro Glu Gly Glu 
            900                 905                 910         


Ala Pro Arg Leu Leu Asp Ala Glu Gly Leu Met Val Thr Gly Gly Arg 
        915                 920                 925             


Arg Ala Glu Ala Lys Glu Thr Glu Pro Glu Ser Leu Glu His Val Arg 
    930                 935                 940                 


Gly Gln Glu Glu Gln Pro Thr His Gln Ala Pro Ala Glu Ala Ala Pro 
945                 950                 955                 960 


Glu Ser Val Gly Glu Ala Glu Thr Ala Glu Ala Met Gly Ser Ala Arg 
                965                 970                 975     


Gly Gly Ala Ala Asn Ser Trp Ser Glu Ala Pro Leu Pro Gly Ser Leu 
            980                 985                 990         


Leu Asp Val Ser Val Pro Arg Ser  Arg Val His Leu Ser  Arg Ser Ser 
        995                 1000                 1005             


Ser Gln  Arg Arg Ser Arg Pro  Ser Phe Arg Arg Thr  Pro Ala Trp 
    1010                 1015                 1020             


Glu Gln  Gln Glu Glu Pro Pro  Ala Pro Asn Pro Pro  Glu Glu Glu 
    1025                 1030                 1035             


Leu Ser  Ala Pro Glu Gln Arg  Pro Leu Gln Leu Glu  Glu Pro Leu 
    1040                 1045                 1050             


Glu Pro  Ser Pro Leu Arg His  Asp Gly Thr Pro Val  Pro Ala Arg 
    1055                 1060                 1065             


Arg Arg  Pro Leu Gly His Gly  Phe Gly Leu Ala His  Pro Gly Met 
    1070                 1075                 1080             


Met Gln  Glu Leu Gln Ala Arg  Leu Gly Arg Pro Lys  Pro Gln 
    1085                 1090                 1095         


<210>  652
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOC1__Homo_sapiens__NP_001636

<400>  652

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  653
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOC2__Homo_sapiens__NP_000474

<400>  653

Met Gly Thr Arg Leu Leu Pro Ala Leu Phe Leu Val Leu Leu Val Leu 
1               5                   10                  15      


Gly Phe Glu Val Gln Gly Thr Gln Gln Pro Gln Gln Asp Glu Met Pro 
            20                  25                  30          


Ser Pro Thr Phe Leu Thr Gln Val Lys Glu Ser Leu Ser Ser Tyr Trp 
        35                  40                  45              


Glu Ser Ala Lys Thr Ala Ala Gln Asn Leu Tyr Glu Lys Thr Tyr Leu 
    50                  55                  60                  


Pro Ala Val Asp Glu Lys Leu Arg Asp Leu Tyr Ser Lys Ser Thr Ala 
65                  70                  75                  80  


Ala Met Ser Thr Tyr Thr Gly Ile Phe Thr Asp Gln Val Leu Ser Val 
                85                  90                  95      


Leu Lys Gly Glu Glu 
            100     


<210>  654
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOC3__Homo_sapiens__NP_000031

<400>  654

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210>  655
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOC4__Homo_sapiens__NP_001637

<400>  655

Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Pro Ser Thr Phe Arg Gly 
65                  70                  75                  80  


Phe Met Gln Thr Tyr Tyr Asp Asp His Leu Arg Asp Leu Gly Pro Leu 
                85                  90                  95      


Thr Lys Ala Trp Phe Leu Glu Ser Lys Asp Ser Leu Leu Lys Lys Thr 
            100                 105                 110         


His Ser Leu Cys Pro Arg Leu Val Cys Gly Asp Lys Asp Gln Gly 
        115                 120                 125         


<210>  656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOD__Homo_sapiens__NP_001638

<400>  656

Met Val Met Leu Leu Leu Leu Leu Ser Ala Leu Ala Gly Leu Phe Gly 
1               5                   10                  15      


Ala Ala Glu Gly Gln Ala Phe His Leu Gly Lys Cys Pro Asn Pro Pro 
            20                  25                  30          


Val Gln Glu Asn Phe Asp Val Asn Lys Tyr Leu Gly Arg Trp Tyr Glu 
        35                  40                  45              


Ile Glu Lys Ile Pro Thr Thr Phe Glu Asn Gly Arg Cys Ile Gln Ala 
    50                  55                  60                  


Asn Tyr Ser Leu Met Glu Asn Gly Lys Ile Lys Val Leu Asn Gln Glu 
65                  70                  75                  80  


Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly Glu Ala Thr Pro 
                85                  90                  95      


Val Asn Leu Thr Glu Pro Ala Lys Leu Glu Val Lys Phe Ser Trp Phe 
            100                 105                 110         


Met Pro Ser Ala Pro Tyr Trp Ile Leu Ala Thr Asp Tyr Glu Asn Tyr 
        115                 120                 125             


Ala Leu Val Tyr Ser Cys Thr Cys Ile Ile Gln Leu Phe His Val Asp 
    130                 135                 140                 


Phe Ala Trp Ile Leu Ala Arg Asn Pro Asn Leu Pro Pro Glu Thr Val 
145                 150                 155                 160 


Asp Ser Leu Lys Asn Ile Leu Thr Ser Asn Asn Ile Asp Val Lys Lys 
                165                 170                 175     


Met Thr Val Thr Asp Gln Val Asn Cys Pro Lys Leu Ser 
            180                 185                 


<210>  657
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOE__Homo_sapiens__NP_001289617

<400>  657

Met Ser Ser Gly Ala Ser Arg Lys Ser Trp Asp Pro Gly Asn Pro Trp 
1               5                   10                  15      


Pro Pro Asp Trp Pro Ile Thr Gly Arg Lys Met Lys Val Leu Trp Ala 
            20                  25                  30          


Ala Leu Leu Val Thr Phe Leu Ala Gly Cys Gln Ala Lys Val Glu Gln 
        35                  40                  45              


Ala Val Glu Thr Glu Pro Glu Pro Glu Leu Arg Gln Gln Thr Glu Trp 
    50                  55                  60                  


Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu Gly Arg Phe Trp Asp Tyr 
65                  70                  75                  80  


Leu Arg Trp Val Gln Thr Leu Ser Glu Gln Val Gln Glu Glu Leu Leu 
                85                  90                  95      


Ser Ser Gln Val Thr Gln Glu Leu Arg Ala Leu Met Asp Glu Thr Met 
            100                 105                 110         


Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro 
        115                 120                 125             


Val Ala Glu Glu Thr Arg Ala Arg Leu Ser Lys Glu Leu Gln Ala Ala 
    130                 135                 140                 


Gln Ala Arg Leu Gly Ala Asp Met Glu Asp Val Cys Gly Arg Leu Val 
145                 150                 155                 160 


Gln Tyr Arg Gly Glu Val Gln Ala Met Leu Gly Gln Ser Thr Glu Glu 
                165                 170                 175     


Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
            180                 185                 190         


Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg Leu Ala Val Tyr Gln Ala 
        195                 200                 205             


Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu Ser Ala Ile Arg Glu Arg 
    210                 215                 220                 


Leu Gly Pro Leu Val Glu Gln Gly Arg Val Arg Ala Ala Thr Val Gly 
225                 230                 235                 240 


Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg Ala Gln Ala Trp Gly Glu 
                245                 250                 255     


Arg Leu Arg Ala Arg Met Glu Glu Met Gly Ser Arg Thr Arg Asp Arg 
            260                 265                 270         


Leu Asp Glu Val Lys Glu Gln Val Ala Glu Val Arg Ala Lys Leu Glu 
        275                 280                 285             


Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala Glu Ala Phe Gln Ala Arg 
    290                 295                 300                 


Leu Lys Ser Trp Phe Glu Pro Leu Val Glu Asp Met Gln Arg Gln Trp 
305                 310                 315                 320 


Ala Gly Leu Val Glu Lys Val Gln Ala Ala Val Gly Thr Ser Ala Ala 
                325                 330                 335     


Pro Val Pro Ser Asp Asn His 
            340             


<210>  658
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOF__Homo_sapiens__NP_001629

<400>  658

Met Thr Gly Leu Cys Gly Tyr Ser Ala Pro Asp Met Arg Gly Leu Arg 
1               5                   10                  15      


Leu Ile Met Ile Pro Val Glu Leu Leu Leu Cys Tyr Leu Leu Leu His 
            20                  25                  30          


Pro Val Asp Ala Thr Ser Tyr Gly Lys Gln Thr Asn Val Leu Met His 
        35                  40                  45              


Phe Pro Leu Ser Leu Glu Ser Gln Thr Pro Ser Ser Asp Pro Leu Ser 
    50                  55                  60                  


Cys Gln Phe Leu His Pro Lys Ser Leu Pro Gly Phe Ser His Met Ala 
65                  70                  75                  80  


Pro Leu Pro Lys Phe Leu Val Ser Leu Ala Leu Arg Asn Ala Leu Glu 
                85                  90                  95      


Glu Ala Gly Cys Gln Ala Asp Val Trp Ala Leu Gln Leu Gln Leu Tyr 
            100                 105                 110         


Arg Gln Gly Gly Val Asn Ala Thr Gln Val Leu Ile Gln His Leu Arg 
        115                 120                 125             


Gly Leu Gln Lys Gly Arg Ser Thr Glu Arg Asn Val Ser Val Glu Ala 
    130                 135                 140                 


Leu Ala Ser Ala Leu Gln Leu Leu Ala Arg Glu Gln Gln Ser Thr Gly 
145                 150                 155                 160 


Arg Val Gly Arg Ser Leu Pro Thr Glu Asp Cys Glu Asn Glu Lys Glu 
                165                 170                 175     


Gln Ala Val His Asn Val Val Gln Leu Leu Pro Gly Val Gly Thr Phe 
            180                 185                 190         


Tyr Asn Leu Gly Thr Ala Leu Tyr Tyr Ala Thr Gln Asn Cys Leu Gly 
        195                 200                 205             


Lys Ala Arg Glu Arg Gly Arg Asp Gly Ala Ile Asp Leu Gly Tyr Asp 
    210                 215                 220                 


Leu Leu Met Thr Met Ala Gly Met Ser Gly Gly Pro Met Gly Leu Ala 
225                 230                 235                 240 


Ile Ser Ala Ala Leu Lys Pro Ala Leu Arg Ser Gly Val Gln Gln Leu 
                245                 250                 255     


Ile Gln Tyr Tyr Gln Asp Gln Lys Asp Ala Asn Ile Ser Gln Pro Glu 
            260                 265                 270         


Thr Thr Lys Glu Gly Leu Arg Ala Ile Ser Asp Val Ser Asp Leu Glu 
        275                 280                 285             


Glu Thr Thr Thr Leu Ala Ser Phe Ile Ser Glu Val Val Ser Ser Ala 
    290                 295                 300                 


Pro Tyr Trp Gly Trp Ala Ile Ile Lys Ser Tyr Asp Leu Asp Pro Gly 
305                 310                 315                 320 


Ala Gly Ser Leu Glu Ile 
                325     


<210>  659
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOH__Homo_sapiens__NP_000033

<400>  659

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val 
1               5                   10                  15      


Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser 
            20                  25                  30          


Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr 
        35                  40                  45              


Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe 
    50                  55                  60                  


Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr 
65                  70                  75                  80  


Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg 
                85                  90                  95      


Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr 
            100                 105                 110         


Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly 
        115                 120                 125             


Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro 
    130                 135                 140                 


Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala 
145                 150                 155                 160 


Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro 
                165                 170                 175     


Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly 
            180                 185                 190         


Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro 
        195                 200                 205             


Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu 
    210                 215                 220                 


Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu 
225                 230                 235                 240 


Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala 
                245                 250                 255     


Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr 
            260                 265                 270         


Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn 
        275                 280                 285             


Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu 
    290                 295                 300                 


Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile 
305                 310                 315                 320 


Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys 
                325                 330                 335     


Thr Asp Ala Ser Asp Val Lys Pro Cys 
            340                 345 


<210>  660
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOL1__Homo_sapiens__NP_001130013

<400>  660

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Val 
1               5                   10                  15      


Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln Ser Lys 
            20                  25                  30          


Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser Ser Ile 
        35                  40                  45              


Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser Thr Gln 
    50                  55                  60                  


Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly Phe Val 
65                  70                  75                  80  


Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg Lys Ala 
                85                  90                  95      


Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn Trp His 
            100                 105                 110         


Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe Pro Arg 
        115                 120                 125             


Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala Leu Ala 
    130                 135                 140                 


Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn Val Val 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val Gly Met 
                165                 170                 175     


Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu Glu Pro 
            180                 185                 190         


Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr Ser Ser 
        195                 200                 205             


Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala His Asp 
    210                 215                 220                 


Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu Phe Leu 
225                 230                 235                 240 


Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr Tyr Gln 
                245                 250                 255     


Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg Ala Arg 
            260                 265                 270         


Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro Arg Val 
        275                 280                 285             


Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg Val Asn 
    290                 295                 300                 


Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr Asp Val 
305                 310                 315                 320 


Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu Val Tyr 
                325                 330                 335     


Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala Glu Glu 
            340                 345                 350         


Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile Leu Asn 
        355                 360                 365             


Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
    370                 375                 380 


<210>  661
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOL2__Homo_sapiens__NP_663612

<400>  661

Met Asn Pro Glu Ser Ser Ile Phe Ile Glu Asp Tyr Leu Lys Tyr Phe 
1               5                   10                  15      


Gln Asp Gln Val Ser Arg Glu Asn Leu Leu Gln Leu Leu Thr Asp Asp 
            20                  25                  30          


Glu Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45              


Ala Asp Glu Leu Arg Lys Ala Leu Asn Lys Leu Ala Ser His Met Val 
    50                  55                  60                  


Met Lys Asp Lys Asn Arg His Asp Lys Asp Gln Gln His Arg Gln Trp 
65                  70                  75                  80  


Phe Leu Lys Glu Phe Pro Arg Leu Lys Arg Glu Leu Glu Asp His Ile 
                85                  90                  95      


Arg Lys Leu Arg Ala Leu Ala Glu Glu Val Glu Gln Val His Arg Gly 
            100                 105                 110         


Thr Thr Ile Ala Asn Val Val Ser Asn Ser Val Gly Thr Thr Ser Gly 
        115                 120                 125             


Ile Leu Thr Leu Leu Gly Leu Gly Leu Ala Pro Phe Thr Glu Gly Ile 
    130                 135                 140                 


Ser Phe Val Leu Leu Asp Thr Gly Met Gly Leu Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Val Ala Gly Ile Thr Cys Ser Val Val Glu Leu Val Asn Lys Leu Arg 
                165                 170                 175     


Ala Arg Ala Gln Ala Arg Asn Leu Asp Gln Ser Gly Thr Asn Val Ala 
            180                 185                 190         


Lys Val Met Lys Glu Phe Val Gly Gly Asn Thr Pro Asn Val Leu Thr 
        195                 200                 205             


Leu Val Asp Asn Trp Tyr Gln Val Thr Gln Gly Ile Gly Arg Asn Ile 
    210                 215                 220                 


Arg Ala Ile Arg Arg Ala Arg Ala Asn Pro Gln Leu Gly Ala Tyr Ala 
225                 230                 235                 240 


Pro Pro Pro His Val Ile Gly Arg Ile Ser Ala Glu Gly Gly Glu Gln 
                245                 250                 255     


Val Glu Arg Val Val Glu Gly Pro Ala Gln Ala Met Ser Arg Gly Thr 
            260                 265                 270         


Met Ile Val Gly Ala Ala Thr Gly Gly Ile Leu Leu Leu Leu Asp Val 
        275                 280                 285             


Val Ser Leu Ala Tyr Glu Ser Lys His Leu Leu Glu Gly Ala Lys Ser 
    290                 295                 300                 


Glu Ser Ala Glu Glu Leu Lys Lys Arg Ala Gln Glu Leu Glu Gly Lys 
305                 310                 315                 320 


Leu Asn Phe Leu Thr Lys Ile His Glu Met Leu Gln Pro Gly Gln Asp 
                325                 330                 335     


Gln 
    


<210>  662
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOL3__Homo_sapiens__NP_663615

<400>  662

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15      


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30          


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45              


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60                  


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr 
65                  70                  75                  80  


Glu Glu Ala Thr Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu 
                85                  90                  95      


Gln Ile Leu Leu Thr Asn Asn Glu Ala Trp Lys Arg Phe Val Thr Ala 
            100                 105                 110         


Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys 
        115                 120                 125             


Lys Leu Arg Thr Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys 
    130                 135                 140                 


Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys 
145                 150                 155                 160 


Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly 
                165                 170                 175     


Ile Glu Glu Val His Arg Gly Cys Thr Ile Ser Asn Val Val Ser Ser 
            180                 185                 190         


Ser Thr Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu 
        195                 200                 205             


Ala Pro Phe Thr Ala Gly Thr Ser Leu Ala Leu Thr Ala Ala Gly Val 
    210                 215                 220                 


Gly Leu Gly Ala Ala Ser Ala Val Thr Gly Ile Thr Thr Ser Ile Val 
225                 230                 235                 240 


Glu His Ser Tyr Thr Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr 
                245                 250                 255     


Ala Thr Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp 
            260                 265                 270         


Ile Thr Pro Asn Leu Leu Ser Leu Leu Asn Asn Tyr Tyr Glu Ala Thr 
        275                 280                 285             


Gln Thr Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg 
    290                 295                 300                 


Ala Arg Leu Pro Val Thr Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly 
305                 310                 315                 320 


Gln Ala Glu Arg Thr Ile Ala Gly Thr Thr Arg Ala Val Ser Arg Gly 
                325                 330                 335     


Ala Arg Ile Leu Ser Ala Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp 
            340                 345                 350         


Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
        355                 360                 365             


Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu 
    370                 375                 380                 


Asn Leu Met Glu Leu Thr Gln Ile Tyr Gln Arg Leu Asn Pro Cys His 
385                 390                 395                 400 


Thr His 
        


<210>  663
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOL4__Homo_sapiens__NP_085146

<400>  663

Met Gly Ser Trp Val Gln Leu Ile Thr Ser Val Gly Val Gln Gln Asn 
1               5                   10                  15      


His Pro Gly Trp Thr Val Ala Gly Gln Phe Gln Glu Lys Lys Arg Phe 
            20                  25                  30          


Thr Glu Glu Val Ile Glu Tyr Phe Gln Lys Lys Val Ser Pro Val His 
        35                  40                  45              


Leu Lys Ile Leu Leu Thr Ser Asp Glu Ala Trp Lys Arg Phe Val Arg 
    50                  55                  60                  


Val Ala Glu Leu Pro Arg Glu Glu Ala Asp Ala Leu Tyr Glu Ala Leu 
65                  70                  75                  80  


Lys Asn Leu Thr Pro Tyr Val Ala Ile Glu Asp Lys Asp Met Gln Gln 
                85                  90                  95      


Lys Glu Gln Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Ile 
            100                 105                 110         


Arg Trp Lys Ile Gln Glu Ser Ile Glu Arg Leu Arg Val Ile Ala Asn 
        115                 120                 125             


Glu Ile Glu Lys Val His Arg Gly Cys Val Ile Ala Asn Val Val Ser 
    130                 135                 140                 


Gly Ser Thr Gly Ile Leu Ser Val Ile Gly Val Met Leu Ala Pro Phe 
145                 150                 155                 160 


Thr Ala Gly Leu Ser Leu Ser Ile Thr Ala Ala Gly Val Gly Leu Gly 
                165                 170                 175     


Ile Ala Ser Ala Thr Ala Gly Ile Ala Ser Ser Ile Val Glu Asn Thr 
            180                 185                 190         


Tyr Thr Arg Ser Ala Glu Leu Thr Ala Ser Arg Leu Thr Ala Thr Ser 
        195                 200                 205             


Thr Asp Gln Leu Glu Ala Leu Arg Asp Ile Leu Arg Asp Ile Thr Pro 
    210                 215                 220                 


Asn Val Leu Ser Phe Ala Leu Asp Phe Asp Glu Ala Thr Lys Met Ile 
225                 230                 235                 240 


Ala Asn Asp Val His Thr Leu Arg Arg Ser Lys Ala Thr Val Gly Arg 
                245                 250                 255     


Pro Leu Ile Ala Trp Arg Tyr Val Pro Ile Asn Val Val Glu Thr Leu 
            260                 265                 270         


Arg Thr Arg Gly Ala Pro Thr Arg Ile Val Arg Lys Val Ala Arg Asn 
        275                 280                 285             


Leu Gly Lys Ala Thr Ser Gly Val Leu Val Val Leu Asp Val Val Asn 
    290                 295                 300                 


Leu Val Gln Asp Ser Leu Asp Leu His Lys Gly Ala Lys Ser Glu Ser 
305                 310                 315                 320 


Ala Glu Ser Leu Arg Gln Trp Ala Gln Glu Leu Glu Glu Asn Leu Asn 
                325                 330                 335     


Glu Leu Thr His Ile His Gln Ser Leu Lys Ala Gly 
            340                 345             


<210>  664
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOL6__Homo_sapiens__NP_085144

<400>  664

Met Asp Asn Gln Ala Glu Arg Glu Ser Glu Ala Gly Val Gly Leu Gln 
1               5                   10                  15      


Arg Asp Glu Asp Asp Ala Pro Leu Cys Glu Asp Val Glu Leu Gln Asp 
            20                  25                  30          


Gly Asp Leu Ser Pro Glu Glu Lys Ile Phe Leu Arg Glu Phe Pro Arg 
        35                  40                  45              


Leu Lys Glu Asp Leu Lys Gly Asn Ile Asp Lys Leu Arg Ala Leu Ala 
    50                  55                  60                  


Asp Asp Ile Asp Lys Thr His Lys Lys Phe Thr Lys Ala Asn Met Val 
65                  70                  75                  80  


Ala Thr Ser Thr Ala Val Ile Ser Gly Val Met Ser Leu Leu Gly Leu 
                85                  90                  95      


Ala Leu Ala Pro Ala Thr Gly Gly Gly Ser Leu Leu Leu Ser Thr Ala 
            100                 105                 110         


Gly Gln Gly Leu Ala Thr Ala Ala Gly Val Thr Ser Ile Val Ser Gly 
        115                 120                 125             


Thr Leu Glu Arg Ser Lys Asn Lys Glu Ala Gln Ala Arg Ala Glu Asp 
    130                 135                 140                 


Ile Leu Pro Thr Tyr Asp Gln Glu Asp Arg Glu Asp Glu Glu Glu Lys 
145                 150                 155                 160 


Ala Asp Tyr Val Thr Ala Ala Gly Lys Ile Ile Tyr Asn Leu Arg Asn 
                165                 170                 175     


Thr Leu Lys Tyr Ala Lys Lys Asn Val Arg Ala Phe Trp Lys Leu Arg 
            180                 185                 190         


Ala Asn Pro Arg Leu Ala Asn Ala Thr Lys Arg Leu Leu Thr Thr Gly 
        195                 200                 205             


Gln Val Ser Ser Arg Ser Arg Val Gln Val Gln Lys Ala Phe Ala Gly 
    210                 215                 220                 


Thr Thr Leu Ala Met Thr Lys Asn Ala Arg Val Leu Gly Gly Val Met 
225                 230                 235                 240 


Ser Ala Phe Ser Leu Gly Tyr Asp Leu Ala Thr Leu Ser Lys Glu Trp 
                245                 250                 255     


Lys His Leu Lys Glu Gly Ala Arg Thr Lys Phe Ala Glu Glu Leu Arg 
            260                 265                 270         


Ala Lys Ala Leu Glu Leu Glu Arg Lys Leu Thr Glu Leu Thr Gln Leu 
        275                 280                 285             


Tyr Lys Ser Leu Gln Gln Lys Val Arg Ser Arg Ala Arg Gly Val Gly 
    290                 295                 300                 


Lys Asp Leu Thr Gly Thr Cys Glu Thr Glu Ala Tyr Trp Lys Glu Leu 
305                 310                 315                 320 


Arg Glu His Val Trp Met Trp Leu Trp Leu Cys Val Cys Leu Cys Val 
                325                 330                 335     


Cys Val Tyr Val Gln Phe Thr 
            340             


<210>  665
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOLD1__Homo_sapiens__NP_001123887

<400>  665

Met Phe Arg Ala Pro Cys His Arg Leu Arg Ala Arg Gly Thr Arg Lys 
1               5                   10                  15      


Ala Arg Ala Gly Ala Trp Arg Gly Cys Thr Phe Pro Cys Leu Gly Lys 
            20                  25                  30          


Gly Met Glu Arg Pro Ala Ala Arg Glu Pro His Gly Pro Asp Ala Leu 
        35                  40                  45              


Arg Arg Phe Gln Gly Leu Leu Leu Asp Arg Arg Gly Arg Leu His Gly 
    50                  55                  60                  


Gln Val Leu Arg Leu Arg Glu Val Ala Arg Arg Leu Glu Arg Leu Arg 
65                  70                  75                  80  


Arg Arg Ser Leu Val Ala Asn Val Ala Gly Ser Ser Leu Ser Ala Thr 
                85                  90                  95      


Gly Ala Leu Ala Ala Ile Val Gly Leu Ser Leu Ser Pro Val Thr Leu 
            100                 105                 110         


Gly Thr Ser Leu Leu Val Ser Ala Val Gly Leu Gly Val Ala Thr Ala 
        115                 120                 125             


Gly Gly Ala Val Thr Ile Thr Ser Asp Leu Ser Leu Ile Phe Cys Asn 
    130                 135                 140                 


Ser Arg Glu Leu Arg Arg Val Gln Glu Ile Ala Ala Thr Cys Gln Asp 
145                 150                 155                 160 


Gln Met Arg Glu Ile Leu Ser Cys Leu Glu Phe Phe Cys Arg Trp Gln 
                165                 170                 175     


Gly Cys Gly Asp Arg Gln Leu Leu Gln Cys Gly Arg Asn Ala Ser Ile 
            180                 185                 190         


Ala Leu Tyr Asn Ser Val Tyr Phe Ile Val Phe Phe Gly Ser Arg Gly 
        195                 200                 205             


Phe Leu Ile Pro Arg Arg Ala Glu Gly Asp Thr Lys Val Ser Gln Ala 
    210                 215                 220                 


Val Leu Lys Ala Lys Ile Gln Lys Leu Ala Glu Ser Leu Glu Ser Cys 
225                 230                 235                 240 


Thr Gly Ala Leu Asp Glu Leu Ser Glu Gln Leu Glu Ser Arg Val Gln 
                245                 250                 255     


Leu Cys Thr Lys Ser Ser Arg Gly His Asp Leu Lys Ile Ser Ala Asp 
            260                 265                 270         


Gln Arg Ala Gly Leu Phe Phe 
        275                 


<210>  666
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOM__Homo_sapiens__NP_001243098

<400>  666

Met Ala Ala Gly Ser Ala Pro Met Gln Leu His Leu Arg Ala Thr Ile 
1               5                   10                  15      


Arg Met Lys Asp Gly Leu Cys Val Pro Arg Lys Trp Ile Tyr His Leu 
            20                  25                  30          


Thr Glu Gly Ser Thr Asp Leu Arg Thr Glu Gly Arg Pro Asp Met Lys 
        35                  40                  45              


Thr Glu Leu Phe Ser Ser Ser Cys Pro Gly Gly Ile Met Leu Asn Glu 
    50                  55                  60                  


Thr Gly Gln Gly Tyr Gln Arg Phe Leu Leu Tyr Asn Arg Ser Pro His 
65                  70                  75                  80  


Pro Pro Glu Lys Cys Val Glu Glu Phe Lys Ser Leu Thr Ser Cys Leu 
                85                  90                  95      


Asp Ser Lys Ala Phe Leu Leu Thr Pro Arg Asn Gln Glu Ala Cys Glu 
            100                 105                 110         


Leu Ser Asn Asn 
        115     


<210>  667
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOO__Homo_sapiens__NP_077027

<400>  667

Met Phe Lys Val Ile Gln Arg Ser Val Gly Pro Ala Ser Leu Ser Leu 
1               5                   10                  15      


Leu Thr Phe Lys Val Tyr Ala Ala Pro Lys Lys Asp Ser Pro Pro Lys 
            20                  25                  30          


Asn Ser Val Lys Val Asp Glu Leu Ser Leu Tyr Ser Val Pro Glu Gly 
        35                  40                  45              


Gln Ser Lys Tyr Val Glu Glu Ala Arg Ser Gln Leu Glu Glu Ser Ile 
    50                  55                  60                  


Ser Gln Leu Arg His Tyr Cys Glu Pro Tyr Thr Thr Trp Cys Gln Glu 
65                  70                  75                  80  


Thr Tyr Ser Gln Thr Lys Pro Lys Met Gln Ser Leu Val Gln Trp Gly 
                85                  90                  95      


Leu Asp Ser Tyr Asp Tyr Leu Gln Asn Ala Pro Pro Gly Phe Phe Pro 
            100                 105                 110         


Arg Leu Gly Val Ile Gly Phe Ala Gly Leu Ile Gly Leu Leu Leu Ala 
        115                 120                 125             


Arg Gly Ser Lys Ile Lys Lys Leu Val Tyr Pro Pro Gly Phe Met Gly 
    130                 135                 140                 


Leu Ala Ala Ser Leu Tyr Tyr Pro Gln Gln Ala Ile Val Phe Ala Gln 
145                 150                 155                 160 


Val Ser Gly Glu Arg Leu Tyr Asp Trp Gly Leu Arg Gly Tyr Ile Val 
                165                 170                 175     


Ile Glu Asp Leu Trp Lys Glu Asn Phe Gln Lys Pro Gly Asn Val Lys 
            180                 185                 190         


Asn Ser Pro Gly Thr Lys 
        195             


<210>  668
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOPT1__Homo_sapiens__NP_115750

<400>  668

Met Leu Pro Cys Ala Ala Gly Ala Arg Gly Arg Gly Ala Met Val Val 
1               5                   10                  15      


Leu Arg Ala Gly Lys Lys Thr Phe Leu Pro Pro Leu Cys Arg Ala Phe 
            20                  25                  30          


Ala Cys Arg Gly Cys Gln Leu Ala Pro Glu Arg Gly Ala Glu Arg Arg 
        35                  40                  45              


Asp Thr Ala Pro Ser Gly Val Ser Arg Phe Cys Pro Pro Arg Lys Ser 
    50                  55                  60                  


Cys His Asp Trp Ile Gly Pro Pro Asp Lys Tyr Ser Asn Leu Arg Pro 
65                  70                  75                  80  


Val His Phe Tyr Ile Pro Glu Asn Glu Ser Pro Leu Glu Gln Lys Leu 
                85                  90                  95      


Arg Lys Leu Arg Gln Glu Thr Gln Glu Trp Asn Gln Gln Phe Trp Ala 
            100                 105                 110         


Asn Gln Asn Leu Thr Phe Ser Lys Glu Lys Glu Glu Phe Ile His Ser 
        115                 120                 125             


Arg Leu Lys Thr Lys Gly Leu Gly Leu Arg Thr Glu Ser Gly Gln Lys 
    130                 135                 140                 


Ala Thr Leu Asn Ala Glu Glu Met Ala Asp Phe Tyr Lys Glu Phe Leu 
145                 150                 155                 160 


Ser Lys Asn Phe Gln Lys His Met Tyr Tyr Asn Arg Asp Trp Tyr Lys 
                165                 170                 175     


Arg Asn Phe Ala Ile Thr Phe Phe Met Gly Lys Val Ala Leu Glu Arg 
            180                 185                 190         


Ile Trp Asn Lys Leu Lys Gln Lys Gln Lys Lys Arg Ser Asn 
        195                 200                 205     


<210>  669
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPBP2__Homo_sapiens__NP_006371

<400>  669

Met Ala Ala Val Glu Leu Glu Trp Ile Pro Glu Thr Leu Tyr Asn Thr 
1               5                   10                  15      


Ala Ile Ser Ala Val Val Asp Asn Tyr Ile Arg Ser Arg Arg Asp Ile 
            20                  25                  30          


Arg Ser Leu Pro Glu Asn Ile Gln Phe Asp Val Tyr Tyr Lys Leu Tyr 
        35                  40                  45              


Gln Gln Gly Arg Leu Cys Gln Leu Gly Ser Glu Phe Cys Glu Leu Glu 
    50                  55                  60                  


Val Phe Ala Lys Val Leu Arg Ala Leu Asp Lys Arg His Leu Leu His 
65                  70                  75                  80  


His Cys Phe Gln Ala Leu Met Asp His Gly Val Lys Val Ala Ser Val 
                85                  90                  95      


Leu Ala Tyr Ser Phe Ser Arg Arg Cys Ser Tyr Ile Ala Glu Ser Asp 
            100                 105                 110         


Ala Ala Val Lys Glu Lys Ala Ile Gln Val Gly Phe Val Leu Gly Gly 
        115                 120                 125             


Phe Leu Ser Asp Ala Gly Trp Tyr Ser Asp Ala Glu Lys Val Phe Leu 
    130                 135                 140                 


Ser Cys Leu Gln Leu Cys Thr Leu His Asp Glu Met Leu His Trp Phe 
145                 150                 155                 160 


Arg Ala Val Glu Cys Cys Val Arg Leu Leu His Val Arg Asn Gly Asn 
                165                 170                 175     


Cys Lys Tyr His Leu Gly Glu Glu Thr Phe Lys Leu Ala Gln Thr Tyr 
            180                 185                 190         


Met Asp Lys Leu Ser Lys His Gly Gln Gln Ala Asn Lys Ala Ala Leu 
        195                 200                 205             


Tyr Gly Glu Leu Cys Ala Leu Leu Phe Ala Lys Ser His Tyr Asp Glu 
    210                 215                 220                 


Ala Tyr Lys Trp Cys Ile Glu Ala Met Lys Glu Ile Thr Ala Gly Leu 
225                 230                 235                 240 


Pro Val Lys Val Val Val Asp Val Leu Arg Gln Ala Ser Lys Ala Cys 
                245                 250                 255     


Val Val Lys Arg Glu Phe Lys Lys Ala Glu Gln Leu Ile Lys His Ala 
            260                 265                 270         


Val Tyr Leu Ala Arg Asp His Phe Gly Ser Lys His Pro Lys Tyr Ser 
        275                 280                 285             


Asp Thr Leu Leu Asp Tyr Gly Phe Tyr Leu Leu Asn Val Asp Asn Ile 
    290                 295                 300                 


Cys Gln Ser Val Ala Ile Tyr Gln Ala Ala Leu Asp Ile Arg Gln Ser 
305                 310                 315                 320 


Val Phe Gly Gly Lys Asn Ile His Val Ala Thr Ala His Glu Asp Leu 
                325                 330                 335     


Ala Tyr Ser Ser Tyr Val His Gln Tyr Ser Ser Gly Lys Phe Asp Asn 
            340                 345                 350         


Ala Leu Phe His Ala Glu Arg Ala Ile Gly Ile Ile Thr His Ile Leu 
        355                 360                 365             


Pro Glu Asp His Leu Leu Leu Ala Ser Ser Lys Arg Val Lys Ala Leu 
    370                 375                 380                 


Ile Leu Glu Glu Ile Ala Ile Asp Cys His Asn Lys Glu Thr Glu Gln 
385                 390                 395                 400 


Arg Leu Leu Gln Glu Ala His Asp Leu His Leu Ser Ser Leu Gln Leu 
                405                 410                 415     


Ala Lys Lys Ala Phe Gly Glu Phe Asn Val Gln Thr Ala Lys His Tyr 
            420                 425                 430         


Gly Asn Leu Gly Arg Leu Tyr Gln Ser Met Arg Lys Phe Lys Glu Ala 
        435                 440                 445             


Glu Glu Met His Ile Lys Ala Ile Gln Ile Lys Glu Gln Leu Leu Gly 
    450                 455                 460                 


Gln Glu Asp Tyr Glu Val Ala Leu Ser Val Gly His Leu Ala Ser Leu 
465                 470                 475                 480 


Tyr Asn Tyr Asp Met Asn Gln Tyr Glu Asn Ala Glu Lys Leu Tyr Leu 
                485                 490                 495     


Arg Ser Ile Ala Ile Gly Lys Lys Leu Phe Gly Glu Gly Tyr Ser Gly 
            500                 505                 510         


Leu Glu Tyr Asp Tyr Arg Gly Leu Ile Lys Leu Tyr Asn Ser Ile Gly 
        515                 520                 525             


Asn Tyr Glu Lys Val Phe Glu Tyr His Asn Val Leu Ser Asn Trp Asn 
    530                 535                 540                 


Arg Leu Arg Asp Arg Gln Tyr Ser Val Thr Asp Ala Leu Glu Asp Val 
545                 550                 555                 560 


Ser Thr Ser Pro Gln Ser Thr Glu Glu Val Val Gln Ser Phe Leu Ile 
                565                 570                 575     


Ser Gln Asn Val Glu Gly Pro Ser Cys 
            580                 585 


<210>  670
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APP__Homo_sapiens__NP_000475

<400>  670

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  671
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPL1__Homo_sapiens__NP_036228

<400>  671

Met Pro Gly Ile Asp Lys Leu Pro Ile Glu Glu Thr Leu Glu Asp Ser 
1               5                   10                  15      


Pro Gln Thr Arg Ser Leu Leu Gly Val Phe Glu Glu Asp Ala Thr Ala 
            20                  25                  30          


Ile Ser Asn Tyr Met Asn Gln Leu Tyr Gln Ala Met His Arg Ile Tyr 
        35                  40                  45              


Asp Ala Gln Asn Glu Leu Ser Ala Ala Thr His Leu Thr Ser Lys Leu 
    50                  55                  60                  


Leu Lys Glu Tyr Glu Lys Gln Arg Phe Pro Leu Gly Gly Asp Asp Glu 
65                  70                  75                  80  


Val Met Ser Ser Thr Leu Gln Gln Phe Ser Lys Val Ile Asp Glu Leu 
                85                  90                  95      


Ser Ser Cys His Ala Val Leu Ser Thr Gln Leu Ala Asp Ala Met Met 
            100                 105                 110         


Phe Pro Ile Thr Gln Phe Lys Glu Arg Asp Leu Lys Glu Ile Leu Thr 
        115                 120                 125             


Leu Lys Glu Val Phe Gln Ile Ala Ser Asn Asp His Asp Ala Ala Ile 
    130                 135                 140                 


Asn Arg Tyr Ser Arg Leu Ser Lys Lys Arg Glu Asn Asp Lys Val Lys 
145                 150                 155                 160 


Tyr Glu Val Thr Glu Asp Val Tyr Thr Ser Arg Lys Lys Gln His Gln 
                165                 170                 175     


Thr Met Met His Tyr Phe Cys Ala Leu Asn Thr Leu Gln Tyr Lys Lys 
            180                 185                 190         


Lys Ile Ala Leu Leu Glu Pro Leu Leu Gly Tyr Met Gln Ala Gln Ile 
        195                 200                 205             


Ser Phe Phe Lys Met Gly Ser Glu Asn Leu Asn Glu Gln Leu Glu Glu 
    210                 215                 220                 


Phe Leu Ala Asn Ile Gly Thr Ser Val Gln Asn Val Arg Arg Glu Met 
225                 230                 235                 240 


Asp Ser Asp Ile Glu Thr Met Gln Gln Thr Ile Glu Asp Leu Glu Val 
                245                 250                 255     


Ala Ser Asp Pro Leu Tyr Val Pro Asp Pro Asp Pro Thr Lys Phe Pro 
            260                 265                 270         


Val Asn Arg Asn Leu Thr Arg Lys Ala Gly Tyr Leu Asn Ala Arg Asn 
        275                 280                 285             


Lys Thr Gly Leu Val Ser Ser Thr Trp Asp Arg Gln Phe Tyr Phe Thr 
    290                 295                 300                 


Gln Gly Gly Asn Leu Met Ser Gln Ala Arg Gly Asp Val Ala Gly Gly 
305                 310                 315                 320 


Leu Ala Met Asp Ile Asp Asn Cys Ser Val Met Ala Val Asp Cys Glu 
                325                 330                 335     


Asp Arg Arg Tyr Cys Phe Gln Ile Thr Ser Phe Asp Gly Lys Lys Ser 
            340                 345                 350         


Ser Ile Leu Gln Ala Glu Ser Lys Lys Asp His Glu Glu Trp Ile Cys 
        355                 360                 365             


Thr Ile Asn Asn Ile Ser Lys Gln Ile Tyr Leu Ser Glu Asn Pro Glu 
    370                 375                 380                 


Glu Thr Ala Ala Arg Val Asn Gln Ser Ala Leu Glu Ala Val Thr Pro 
385                 390                 395                 400 


Ser Pro Ser Phe Gln Gln Arg His Glu Ser Leu Arg Pro Ala Ala Gly 
                405                 410                 415     


Gln Ser Arg Pro Pro Thr Ala Arg Thr Ser Ser Ser Gly Ser Leu Gly 
            420                 425                 430         


Ser Glu Ser Thr Asn Leu Ala Ala Leu Ser Leu Asp Ser Leu Val Ala 
        435                 440                 445             


Pro Asp Thr Pro Ile Gln Phe Asp Ile Ile Ser Pro Val Cys Glu Asp 
    450                 455                 460                 


Gln Pro Gly Gln Ala Lys Ala Phe Gly Gln Gly Gly Arg Arg Thr Asn 
465                 470                 475                 480 


Pro Phe Gly Glu Ser Gly Gly Ser Thr Lys Ser Glu Thr Glu Asp Ser 
                485                 490                 495     


Ile Leu His Gln Leu Phe Ile Val Arg Phe Leu Gly Ser Met Glu Val 
            500                 505                 510         


Lys Ser Asp Asp His Pro Asp Val Val Tyr Glu Thr Met Arg Gln Ile 
        515                 520                 525             


Leu Ala Ala Arg Ala Ile His Asn Ile Phe Arg Met Thr Glu Ser His 
    530                 535                 540                 


Leu Leu Val Thr Cys Asp Cys Leu Lys Leu Ile Asp Pro Gln Thr Gln 
545                 550                 555                 560 


Val Thr Arg Leu Thr Phe Pro Leu Pro Cys Val Val Leu Tyr Ala Thr 
                565                 570                 575     


His Gln Glu Asn Lys Arg Leu Phe Gly Phe Val Leu Arg Thr Ser Ser 
            580                 585                 590         


Gly Arg Ser Glu Ser Asn Leu Ser Ser Val Cys Tyr Ile Phe Glu Ser 
        595                 600                 605             


Asn Asn Glu Gly Glu Lys Ile Cys Asp Ser Val Gly Leu Ala Lys Gln 
    610                 615                 620                 


Ile Ala Leu His Ala Glu Leu Asp Arg Arg Ala Ser Glu Lys Gln Lys 
625                 630                 635                 640 


Glu Ile Glu Arg Val Lys Glu Lys Gln Gln Lys Glu Leu Asn Lys Gln 
                645                 650                 655     


Lys Gln Ile Glu Lys Asp Leu Glu Glu Gln Ser Arg Leu Ile Ala Ala 
            660                 665                 670         


Ser Ser Arg Pro Asn Gln Ala Ser Ser Glu Gly Gln Phe Val Val Leu 
        675                 680                 685             


Ser Ser Ser Gln Ser Glu Glu Ser Asp Leu Gly Glu Gly Gly Lys Lys 
    690                 695                 700                 


Arg Glu Ser Glu Ala 
705                 


<210>  672
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPL2__Homo_sapiens__NP_001238833

<400>  672

Met Pro Ala Val Asp Lys Leu Leu Leu Glu Glu Ala Leu Gln Asp Ser 
1               5                   10                  15      


Pro Gln Thr Arg Ser Leu Leu Ser Val Phe Glu Glu Asp Ala Gly Thr 
            20                  25                  30          


Leu Thr Asp Tyr Thr Asn Gln Leu Leu Gln Ala Met Gln Arg Val Tyr 
        35                  40                  45              


Gly Ala Gln Asn Glu Met Cys Leu Ala Thr Gln Gln Leu Ser Lys Gln 
    50                  55                  60                  


Leu Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu Gly Lys Gly Asp Glu 
65                  70                  75                  80  


Glu Val Ile Ser Thr Leu His Tyr Phe Ser Lys Val Val Asp Glu Leu 
                85                  90                  95      


Asn Leu Leu His Thr Glu Leu Ala Lys Gln Leu Ala Asp Thr Met Val 
            100                 105                 110         


Leu Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu Thr Glu Val Ser Thr 
        115                 120                 125             


Leu Lys Asp Leu Phe Gly Leu Ala Ser Asn Asp Val Cys Leu Phe Leu 
    130                 135                 140                 


Glu His Asp Leu Ser Met Ala Lys Tyr Ser Arg Leu Pro Lys Lys Lys 
145                 150                 155                 160 


Glu Asn Glu Lys Val Lys Thr Glu Val Gly Lys Glu Val Ala Ala Ala 
                165                 170                 175     


Arg Arg Lys Gln His Leu Ser Ser Leu Gln Tyr Tyr Cys Ala Leu Asn 
            180                 185                 190         


Ala Leu Gln Tyr Arg Lys Gln Met Ala Met Met Glu Pro Met Ile Gly 
        195                 200                 205             


Phe Ala His Gly Gln Ile Asn Phe Phe Lys Lys Gly Ala Glu Met Phe 
    210                 215                 220                 


Ser Lys Arg Met Asp Ser Phe Leu Ser Ser Val Ala Asp Met Val Gln 
225                 230                 235                 240 


Ser Ile Gln Val Glu Leu Glu Ala Glu Ala Glu Lys Met Arg Val Ser 
                245                 250                 255     


Gln Gln Glu Leu Leu Ser Val Asp Glu Ser Val Tyr Thr Pro Asp Ser 
            260                 265                 270         


Asp Val Ala Ala Pro Gln Ile Asn Arg Asn Leu Ile Gln Lys Ala Gly 
        275                 280                 285             


Tyr Leu Asn Leu Arg Asn Lys Thr Gly Leu Val Thr Thr Thr Trp Glu 
    290                 295                 300                 


Arg Leu Tyr Phe Phe Thr Gln Gly Gly Asn Leu Met Cys Gln Pro Arg 
305                 310                 315                 320 


Gly Ala Val Ala Gly Gly Leu Ile Gln Asp Leu Asp Asn Cys Ser Val 
                325                 330                 335     


Met Ala Val Asp Cys Glu Asp Arg Arg Tyr Cys Phe Gln Ile Thr Thr 
            340                 345                 350         


Pro Asn Gly Lys Ser Gly Ile Ile Leu Gln Ala Glu Ser Arg Lys Glu 
        355                 360                 365             


Asn Glu Glu Trp Ile Cys Ala Ile Asn Asn Ile Ser Arg Gln Ile Tyr 
    370                 375                 380                 


Leu Thr Asp Asn Pro Glu Ala Val Ala Ile Lys Leu Asn Gln Thr Ala 
385                 390                 395                 400 


Leu Gln Ala Val Thr Pro Ile Thr Ser Phe Gly Lys Lys Gln Glu Ser 
                405                 410                 415     


Ser Cys Pro Ser Gln Asn Leu Lys Asn Ser Glu Met Glu Asn Glu Asn 
            420                 425                 430         


Asp Lys Ile Val Pro Lys Ala Thr Ala Ser Leu Pro Glu Ala Glu Glu 
        435                 440                 445             


Leu Ile Ala Pro Gly Thr Pro Ile Gln Phe Asp Ile Val Leu Pro Ala 
    450                 455                 460                 


Thr Glu Phe Leu Asp Gln Asn Arg Gly Ser Arg Arg Thr Asn Pro Phe 
465                 470                 475                 480 


Gly Glu Thr Glu Asp Glu Ser Phe Pro Glu Ala Glu Asp Ser Leu Leu 
                485                 490                 495     


Gln Gln Met Phe Ile Val Arg Phe Leu Gly Ser Met Ala Val Lys Thr 
            500                 505                 510         


Asp Ser Thr Thr Glu Val Ile Tyr Glu Ala Met Arg Gln Val Leu Ala 
        515                 520                 525             


Ala Arg Ala Ile His Asn Ile Phe Arg Met Thr Glu Ser His Leu Met 
    530                 535                 540                 


Val Thr Ser Gln Ser Leu Arg Leu Ile Asp Pro Gln Thr Gln Val Ser 
545                 550                 555                 560 


Arg Ala Asn Phe Glu Leu Thr Ser Val Thr Gln Phe Ala Ala His Gln 
                565                 570                 575     


Glu Asn Lys Arg Leu Val Gly Phe Val Ile Arg Val Pro Glu Ser Thr 
            580                 585                 590         


Gly Glu Glu Ser Leu Ser Thr Tyr Ile Phe Glu Ser Asn Ser Glu Gly 
        595                 600                 605             


Glu Lys Ile Cys Tyr Ala Ile Asn Leu Gly Lys Glu Ile Ile Glu Val 
    610                 615                 620                 


Gln Lys Asp Pro Glu Ala Leu Ala Gln Leu Met Leu Ser Ile Pro Leu 
625                 630                 635                 640 


Thr Asn Asp Gly Lys Tyr Val Leu Leu Asn Asp Gln Pro Asp Asp Asp 
                645                 650                 655     


Asp Gly Asn Pro Asn Glu His Arg Gly Ala Glu Ser Glu Ala 
            660                 665                 670 


<210>  673
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APRT__Homo_sapiens__NP_000476

<400>  673

Met Ala Asp Ser Glu Leu Gln Leu Val Glu Gln Arg Ile Arg Ser Phe 
1               5                   10                  15      


Pro Asp Phe Pro Thr Pro Gly Val Val Phe Arg Asp Ile Ser Pro Val 
            20                  25                  30          


Leu Lys Asp Pro Ala Ser Phe Arg Ala Ala Ile Gly Leu Leu Ala Arg 
        35                  40                  45              


His Leu Lys Ala Thr His Gly Gly Arg Ile Asp Tyr Ile Ala Gly Leu 
    50                  55                  60                  


Asp Ser Arg Gly Phe Leu Phe Gly Pro Ser Leu Ala Gln Glu Leu Gly 
65                  70                  75                  80  


Leu Gly Cys Val Leu Ile Arg Lys Arg Gly Lys Leu Pro Gly Pro Thr 
                85                  90                  95      


Leu Trp Ala Ser Tyr Ser Leu Glu Tyr Gly Lys Ala Glu Leu Glu Ile 
            100                 105                 110         


Gln Lys Asp Ala Leu Glu Pro Gly Gln Arg Val Val Val Val Asp Asp 
        115                 120                 125             


Leu Leu Ala Thr Gly Gly Thr Met Asn Ala Ala Cys Glu Leu Leu Gly 
    130                 135                 140                 


Arg Leu Gln Ala Glu Val Leu Glu Cys Val Ser Leu Val Glu Leu Thr 
145                 150                 155                 160 


Ser Leu Lys Gly Arg Glu Lys Leu Ala Pro Val Pro Phe Phe Ser Leu 
                165                 170                 175     


Leu Gln Tyr Glu 
            180 


<210>  674
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APTX__Homo_sapiens__NP_001182177

<400>  674

Met Ser Asn Val Asn Leu Ser Val Ser Asp Phe Trp Arg Val Met Met 
1               5                   10                  15      


Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg Ile Arg 
            20                  25                  30          


Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu Thr Lys 
        35                  40                  45              


Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu Lys Ala Glu 
    50                  55                  60                  


Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Val Gly Val Asn Pro Thr 
65                  70                  75                  80  


Ser Ile Asp Ser Val Val Ile Gly Lys Asp Gln Glu Val Lys Leu Gln 
                85                  90                  95      


Pro Gly Gln Val Leu His Met Val Asn Glu Leu Tyr Pro Tyr Ile Val 
            100                 105                 110         


Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly Leu Glu Thr His Arg Lys 
        115                 120                 125             


Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile Glu Arg Asp Ala Ala Gln 
    130                 135                 140                 


Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro Gly Ser Asn Ser Gly Gln 
145                 150                 155                 160 


Cys Ser Val Pro Leu Lys Lys Gly Lys Asp Ala Pro Ile Lys Lys Glu 
                165                 170                 175     


Ser Leu Gly His Trp Ser Gln Gly Leu Lys Ile Ser Met Gln Asp Pro 
            180                 185                 190         


Lys Met Gln Val Tyr Lys Asp Glu Gln Val Val Val Ile Lys Asp Lys 
        195                 200                 205             


Tyr Pro Lys Ala Arg Tyr His Trp Leu Val Leu Pro Trp Thr Ser Ile 
    210                 215                 220                 


Ser Ser Leu Lys Ala Val Ala Arg Glu His Leu Glu Leu Leu Lys His 
225                 230                 235                 240 


Met His Thr Val Gly Glu Lys Val Ile Val Asp Phe Ala Gly Ser Ser 
                245                 250                 255     


Lys Leu Arg Phe Arg Leu Gly Tyr His Ala Ile Pro Ser Met Ser His 
            260                 265                 270         


Val His Leu His Val Ile Ser Gln Asp Phe Asp Ser Pro Cys Leu Lys 
        275                 280                 285             


Asn Lys Lys His Trp Asn Ser Phe Asn Thr Glu Tyr Phe Leu Glu Ser 
    290                 295                 300                 


Gln Ala Val Ile Glu Met Val Gln Glu Ala Gly Arg Val Thr Val Arg 
305                 310                 315                 320 


Asp Gly Met Pro Glu Leu Leu Lys Leu Pro Leu Arg Cys His Glu Cys 
                325                 330                 335     


Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu Lys Glu His Leu Arg Lys 
            340                 345                 350         


His Trp Thr Gln 
        355     


<210>  675
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP10__Homo_sapiens__NP_536354

<400>  675

Met Val Phe Thr Gln Ala Pro Ala Glu Ile Met Gly His Leu Arg Ile 
1               5                   10                  15      


Arg Ser Leu Leu Ala Arg Gln Cys Leu Ala Glu Phe Leu Gly Val Phe 
            20                  25                  30          


Val Leu Met Leu Leu Thr Gln Gly Ala Val Ala Gln Ala Val Thr Ser 
        35                  40                  45              


Gly Glu Thr Lys Gly Asn Phe Phe Thr Met Phe Leu Ala Gly Ser Leu 
    50                  55                  60                  


Ala Val Thr Ile Ala Ile Tyr Val Gly Gly Asn Val Ser Gly Ala His 
65                  70                  75                  80  


Leu Asn Pro Ala Phe Ser Leu Ala Met Cys Ile Val Gly Arg Leu Pro 
                85                  90                  95      


Trp Val Lys Leu Pro Ile Tyr Ile Leu Val Gln Leu Leu Ser Ala Phe 
            100                 105                 110         


Cys Ala Ser Gly Ala Thr Tyr Val Leu Tyr His Asp Ala Leu Gln Asn 
        115                 120                 125             


Tyr Thr Gly Gly Asn Leu Thr Val Thr Gly Pro Lys Glu Thr Ala Ser 
    130                 135                 140                 


Ile Phe Ala Thr Tyr Pro Ala Pro Tyr Leu Ser Leu Asn Asn Gly Phe 
145                 150                 155                 160 


Leu Asp Gln Val Leu Gly Thr Gly Met Leu Ile Val Gly Leu Leu Ala 
                165                 170                 175     


Ile Leu Asp Arg Arg Asn Lys Gly Val Pro Ala Gly Leu Glu Pro Val 
            180                 185                 190         


Val Val Gly Met Leu Ile Leu Ala Leu Gly Leu Ser Met Gly Ala Asn 
        195                 200                 205             


Cys Gly Ile Pro Leu Asn Pro Ala Arg Asp Leu Gly Pro Arg Leu Phe 
    210                 215                 220                 


Thr Tyr Val Ala Gly Trp Gly Pro Glu Val Phe Ser Ala Gly Asn Gly 
225                 230                 235                 240 


Trp Trp Trp Val Pro Val Val Ala Pro Leu Val Gly Ala Thr Val Gly 
                245                 250                 255     


Thr Ala Thr Tyr Gln Leu Leu Val Ala Leu His His Pro Glu Gly Pro 
            260                 265                 270         


Glu Pro Ala Gln Asp Leu Val Ser Ala Gln His Lys Ala Ser Glu Leu 
        275                 280                 285             


Glu Thr Pro Ala Ser Ala Gln Met Leu Glu Cys Lys Leu 
    290                 295                 300     


<210>  676
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP1__Homo_sapiens__NP_001171989

<400>  676

Met Pro Gly Ala Arg Pro Leu Pro Leu Val Leu Val Pro Gln Asn Thr 
1               5                   10                  15      


Leu Ala Trp Met Gln Leu Asp Ala Lys Ala Pro Ala His Pro Arg Pro 
            20                  25                  30          


Leu Gln Leu Leu Gly Arg Val Gly Pro Gly Ser Arg Gln Leu Ala Asp 
        35                  40                  45              


Gly Val Asn Ser Gly Gln Gly Leu Gly Ile Glu Ile Ile Gly Thr Leu 
    50                  55                  60                  


Gln Leu Val Leu Cys Val Leu Ala Thr Thr Asp Arg Arg Arg Arg Asp 
65                  70                  75                  80  


Leu Gly Gly Ser Ala Pro Leu Ala Ile Gly Leu Ser Val Ala Leu Gly 
                85                  90                  95      


His Leu Leu Ala Ile Asp Tyr Thr Gly Cys Gly Ile Asn Pro Ala Arg 
            100                 105                 110         


Ser Phe Gly Ser Ala Val Ile Thr His Asn Phe Ser Asn His Trp Ile 
        115                 120                 125             


Phe Trp Val Gly Pro Phe Ile Gly Gly Ala Leu Ala Val Leu Ile Tyr 
    130                 135                 140                 


Asp Phe Ile Leu Ala Pro Arg Ser Ser Asp Leu Thr Asp Arg Val Lys 
145                 150                 155                 160 


Val Trp Thr Ser Gly Gln Val Glu Glu Tyr Asp Leu Asp Ala Asp Asp 
                165                 170                 175     


Ile Asn Ser Arg Val Glu Met Lys Pro Lys 
            180                 185     


<210>  677
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP2__Homo_sapiens__NP_000477

<400>  677

Met Trp Glu Leu Arg Ser Ile Ala Phe Ser Arg Ala Val Phe Ala Glu 
1               5                   10                  15      


Phe Leu Ala Thr Leu Leu Phe Val Phe Phe Gly Leu Gly Ser Ala Leu 
            20                  25                  30          


Asn Trp Pro Gln Ala Leu Pro Ser Val Leu Gln Ile Ala Met Ala Phe 
        35                  40                  45              


Gly Leu Gly Ile Gly Thr Leu Val Gln Ala Leu Gly His Ile Ser Gly 
    50                  55                  60                  


Ala His Ile Asn Pro Ala Val Thr Val Ala Cys Leu Val Gly Cys His 
65                  70                  75                  80  


Val Ser Val Leu Arg Ala Ala Phe Tyr Val Ala Ala Gln Leu Leu Gly 
                85                  90                  95      


Ala Val Ala Gly Ala Ala Leu Leu His Glu Ile Thr Pro Ala Asp Ile 
            100                 105                 110         


Arg Gly Asp Leu Ala Val Asn Ala Leu Ser Asn Ser Thr Thr Ala Gly 
        115                 120                 125             


Gln Ala Val Thr Val Glu Leu Phe Leu Thr Leu Gln Leu Val Leu Cys 
    130                 135                 140                 


Ile Phe Ala Ser Thr Asp Glu Arg Arg Gly Glu Asn Pro Gly Thr Pro 
145                 150                 155                 160 


Ala Leu Ser Ile Gly Phe Ser Val Ala Leu Gly His Leu Leu Gly Ile 
                165                 170                 175     


His Tyr Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Leu Ala Pro Ala 
            180                 185                 190         


Val Val Thr Gly Lys Phe Asp Asp His Trp Val Phe Trp Ile Gly Pro 
        195                 200                 205             


Leu Val Gly Ala Ile Leu Gly Ser Leu Leu Tyr Asn Tyr Val Leu Phe 
    210                 215                 220                 


Pro Pro Ala Lys Ser Leu Ser Glu Arg Leu Ala Val Leu Lys Gly Leu 
225                 230                 235                 240 


Glu Pro Asp Thr Asp Trp Glu Glu Arg Glu Val Arg Arg Arg Gln Ser 
                245                 250                 255     


Val Glu Leu His Ser Pro Gln Ser Leu Pro Arg Gly Thr Lys Ala 
            260                 265                 270     


<210>  678
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP3__Homo_sapiens__NP_004916

<400>  678

Met Gly Arg Gln Lys Glu Leu Val Ser Arg Cys Gly Glu Met Leu His 
1               5                   10                  15      


Ile Arg Tyr Arg Leu Leu Arg Gln Ala Leu Ala Glu Cys Leu Gly Thr 
            20                  25                  30          


Leu Ile Leu Val Met Phe Gly Cys Gly Ser Val Ala Gln Val Val Leu 
        35                  40                  45              


Ser Arg Gly Thr His Gly Gly Phe Leu Thr Ile Asn Leu Ala Phe Gly 
    50                  55                  60                  


Phe Ala Val Thr Leu Gly Ile Leu Ile Ala Gly Gln Val Ser Gly Ala 
65                  70                  75                  80  


His Leu Asn Pro Ala Val Thr Phe Ala Met Cys Phe Leu Ala Arg Glu 
                85                  90                  95      


Pro Trp Ile Lys Leu Pro Ile Tyr Thr Leu Ala Gln Thr Leu Gly Ala 
            100                 105                 110         


Phe Leu Gly Ala Gly Ile Val Phe Gly Leu Tyr Tyr Asp Ala Ile Trp 
        115                 120                 125             


His Phe Ala Asp Asn Gln Leu Phe Val Ser Gly Pro Asn Gly Thr Ala 
    130                 135                 140                 


Gly Ile Phe Ala Thr Tyr Pro Ser Gly His Leu Asp Met Ile Asn Gly 
145                 150                 155                 160 


Phe Phe Asp Gln Phe Ile Gly Thr Ala Ser Leu Ile Val Cys Val Leu 
                165                 170                 175     


Ala Ile Val Asp Pro Tyr Asn Asn Pro Val Pro Arg Gly Leu Glu Ala 
            180                 185                 190         


Phe Thr Val Gly Leu Val Val Leu Val Ile Gly Thr Ser Met Gly Phe 
        195                 200                 205             


Asn Ser Gly Tyr Ala Val Asn Pro Ala Arg Asp Phe Gly Pro Arg Leu 
    210                 215                 220                 


Phe Thr Ala Leu Ala Gly Trp Gly Ser Ala Val Phe Thr Thr Gly Gln 
225                 230                 235                 240 


His Trp Trp Trp Val Pro Ile Val Ser Pro Leu Leu Gly Ser Ile Ala 
                245                 250                 255     


Gly Val Phe Val Tyr Gln Leu Met Ile Gly Cys His Leu Glu Gln Pro 
            260                 265                 270         


Pro Pro Ser Asn Glu Glu Glu Asn Val Lys Leu Ala His Val Lys His 
        275                 280                 285             


Lys Glu Gln Ile 
    290         


<210>  679
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP4__Homo_sapiens__NP_001641

<400>  679

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu 
1               5                   10                  15      


Cys Thr Arg Glu Asn Ile Met Val Ala Phe Lys Gly Val Trp Thr Gln 
            20                  25                  30          


Ala Phe Trp Lys Ala Val Thr Ala Glu Phe Leu Ala Met Leu Ile Phe 
        35                  40                  45              


Val Leu Leu Ser Leu Gly Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys 
    50                  55                  60                  


Pro Leu Pro Val Asp Met Val Leu Ile Ser Leu Cys Phe Gly Leu Ser 
65                  70                  75                  80  


Ile Ala Thr Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile 
                85                  90                  95      


Asn Pro Ala Val Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile 
            100                 105                 110         


Ala Lys Ser Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile 
        115                 120                 125             


Gly Ala Gly Ile Leu Tyr Leu Val Thr Pro Pro Ser Val Val Gly Gly 
    130                 135                 140                 


Leu Gly Val Thr Met Val His Gly Asn Leu Thr Ala Gly His Gly Leu 
145                 150                 155                 160 


Leu Val Glu Leu Ile Ile Thr Phe Gln Leu Val Phe Thr Ile Phe Ala 
                165                 170                 175     


Ser Cys Asp Ser Lys Arg Thr Asp Val Thr Gly Ser Ile Ala Leu Ala 
            180                 185                 190         


Ile Gly Phe Ser Val Ala Ile Gly His Leu Phe Ala Ile Asn Tyr Thr 
        195                 200                 205             


Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val Ile Met 
    210                 215                 220                 


Gly Asn Trp Glu Asn His Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly 
225                 230                 235                 240 


Ala Val Leu Ala Gly Gly Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val 
                245                 250                 255     


Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln 
            260                 265                 270         


Thr Lys Gly Ser Tyr Met Glu Val Glu Asp Asn Arg Ser Gln Val Glu 
        275                 280                 285             


Thr Asp Asp Leu Ile Leu Lys Pro Gly Val Val His Val Ile Asp Val 
    290                 295                 300                 


Asp Arg Gly Glu Glu Lys Lys Gly Lys Asp Gln Ser Gly Glu Val Leu 
305                 310                 315                 320 


Ser Ser Val 
            


<210>  680
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP5__Homo_sapiens__NP_001642

<400>  680

Met Lys Lys Glu Val Cys Ser Val Ala Phe Leu Lys Ala Val Phe Ala 
1               5                   10                  15      


Glu Phe Leu Ala Thr Leu Ile Phe Val Phe Phe Gly Leu Gly Ser Ala 
            20                  25                  30          


Leu Lys Trp Pro Ser Ala Leu Pro Thr Ile Leu Gln Ile Ala Leu Ala 
        35                  40                  45              


Phe Gly Leu Ala Ile Gly Thr Leu Ala Gln Ala Leu Gly Pro Val Ser 
    50                  55                  60                  


Gly Gly His Ile Asn Pro Ala Ile Thr Leu Ala Leu Leu Val Gly Asn 
65                  70                  75                  80  


Gln Ile Ser Leu Leu Arg Ala Phe Phe Tyr Val Ala Ala Gln Leu Val 
                85                  90                  95      


Gly Ala Ile Ala Gly Ala Gly Ile Leu Tyr Gly Val Ala Pro Leu Asn 
            100                 105                 110         


Ala Arg Gly Asn Leu Ala Val Asn Ala Leu Asn Asn Asn Thr Thr Gln 
        115                 120                 125             


Gly Gln Ala Met Val Val Glu Leu Ile Leu Thr Phe Gln Leu Ala Leu 
    130                 135                 140                 


Cys Ile Phe Ala Ser Thr Asp Ser Arg Arg Thr Ser Pro Val Gly Ser 
145                 150                 155                 160 


Pro Ala Leu Ser Ile Gly Leu Ser Val Thr Leu Gly His Leu Val Gly 
                165                 170                 175     


Ile Tyr Phe Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Phe Gly Pro 
            180                 185                 190         


Ala Val Val Met Asn Arg Phe Ser Pro Ala His Trp Val Phe Trp Val 
        195                 200                 205             


Gly Pro Ile Val Gly Ala Val Leu Ala Ala Ile Leu Tyr Phe Tyr Leu 
    210                 215                 220                 


Leu Phe Pro Asn Ser Leu Ser Leu Ser Glu Arg Val Ala Ile Ile Lys 
225                 230                 235                 240 


Gly Thr Tyr Glu Pro Asp Glu Asp Trp Glu Glu Gln Arg Glu Glu Arg 
                245                 250                 255     


Lys Lys Thr Met Glu Leu Thr Thr Arg 
            260                 265 


<210>  681
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP6__Homo_sapiens__NP_001643

<400>  681

Met Asp Ala Val Glu Pro Gly Gly Arg Gly Trp Ala Ser Met Leu Ala 
1               5                   10                  15      


Cys Arg Leu Trp Lys Ala Ile Ser Arg Ala Leu Phe Ala Glu Phe Leu 
            20                  25                  30          


Ala Thr Gly Leu Tyr Val Phe Phe Gly Val Gly Ser Val Met Arg Trp 
        35                  40                  45              


Pro Thr Ala Leu Pro Ser Val Leu Gln Ile Ala Ile Thr Phe Asn Leu 
    50                  55                  60                  


Val Thr Ala Met Ala Val Gln Val Thr Trp Lys Ala Ser Gly Ala His 
65                  70                  75                  80  


Ala Asn Pro Ala Val Thr Leu Ala Phe Leu Val Gly Ser His Ile Ser 
                85                  90                  95      


Leu Pro Arg Ala Val Ala Tyr Val Ala Ala Gln Leu Val Gly Ala Thr 
            100                 105                 110         


Val Gly Ala Ala Leu Leu Tyr Gly Val Met Pro Gly Asp Ile Arg Glu 
        115                 120                 125             


Thr Leu Gly Ile Asn Val Val Arg Asn Ser Val Ser Thr Gly Gln Ala 
    130                 135                 140                 


Val Ala Val Glu Leu Leu Leu Thr Leu Gln Leu Val Leu Cys Val Phe 
145                 150                 155                 160 


Ala Ser Thr Asp Ser Arg Gln Thr Ser Gly Ser Pro Ala Thr Met Ile 
                165                 170                 175     


Gly Ile Ser Val Ala Leu Gly His Leu Ile Gly Ile His Phe Thr Gly 
            180                 185                 190         


Cys Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Ile Ile Ile Gly 
        195                 200                 205             


Lys Phe Thr Val His Trp Val Phe Trp Val Gly Pro Leu Met Gly Ala 
    210                 215                 220                 


Leu Leu Ala Ser Leu Ile Tyr Asn Phe Val Leu Phe Pro Asp Thr Lys 
225                 230                 235                 240 


Thr Leu Ala Gln Arg Leu Ala Ile Leu Thr Gly Thr Val Glu Val Gly 
                245                 250                 255     


Thr Gly Ala Gly Ala Gly Ala Glu Pro Leu Lys Lys Glu Ser Gln Pro 
            260                 265                 270         


Gly Ser Gly Ala Val Glu Met Glu Ser Val 
        275                 280         


<210>  682
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP7__Homo_sapiens__NP_001161

<400>  682

Met Val Gln Ala Ser Gly His Arg Arg Ser Thr Arg Gly Ser Lys Met 
1               5                   10                  15      


Val Ser Trp Ser Val Ile Ala Lys Ile Gln Glu Ile Leu Gln Arg Lys 
            20                  25                  30          


Met Val Arg Glu Phe Leu Ala Glu Phe Met Ser Thr Tyr Val Met Met 
        35                  40                  45              


Val Phe Gly Leu Gly Ser Val Ala His Met Val Leu Asn Lys Lys Tyr 
    50                  55                  60                  


Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met 
65                  70                  75                  80  


Gly Val His Val Ala Gly Arg Ile Ser Gly Ala His Met Asn Ala Ala 
                85                  90                  95      


Val Thr Phe Ala Asn Cys Ala Leu Gly Arg Val Pro Trp Arg Lys Phe 
            100                 105                 110         


Pro Val Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala 
        115                 120                 125             


Thr Ile Tyr Ser Leu Phe Tyr Thr Ala Ile Leu His Phe Ser Gly Gly 
    130                 135                 140                 


Gln Leu Met Val Thr Gly Pro Val Ala Thr Ala Gly Ile Phe Ala Thr 
145                 150                 155                 160 


Tyr Leu Pro Asp His Met Thr Leu Trp Arg Gly Phe Leu Asn Glu Ala 
                165                 170                 175     


Trp Leu Thr Gly Met Leu Gln Leu Cys Leu Phe Ala Ile Thr Asp Gln 
            180                 185                 190         


Glu Asn Asn Pro Ala Leu Pro Gly Thr Glu Ala Leu Val Ile Gly Ile 
        195                 200                 205             


Leu Val Val Ile Ile Gly Val Ser Leu Gly Met Asn Thr Gly Tyr Ala 
    210                 215                 220                 


Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg Ile Phe Thr Phe Ile Ala 
225                 230                 235                 240 


Gly Trp Gly Lys Gln Val Phe Ser Asn Gly Glu Asn Trp Trp Trp Val 
                245                 250                 255     


Pro Val Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Ile Tyr 
            260                 265                 270         


Leu Val Phe Ile Gly Ser Thr Ile Pro Arg Glu Pro Leu Lys Leu Glu 
        275                 280                 285             


Asp Ser Val Ala Tyr Glu Asp His Gly Ile Thr Val Leu Pro Lys Met 
    290                 295                 300                 


Gly Ser His Glu Pro Thr Ile Ser Pro Leu Thr Pro Val Ser Val Ser 
305                 310                 315                 320 


Pro Ala Asn Arg Ser Ser Val His Pro Ala Pro Pro Leu His Glu Ser 
                325                 330                 335     


Met Ala Leu Glu His Phe 
            340         


<210>  683
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP8__Homo_sapiens__NP_001160

<400>  683

Met Ser Gly Glu Ile Ala Met Cys Glu Pro Glu Phe Gly Asn Asp Lys 
1               5                   10                  15      


Ala Arg Glu Pro Ser Val Gly Gly Arg Trp Arg Val Ser Trp Tyr Glu 
            20                  25                  30          


Arg Phe Val Gln Pro Cys Leu Val Glu Leu Leu Gly Ser Ala Leu Phe 
        35                  40                  45              


Ile Phe Ile Gly Cys Leu Ser Val Ile Glu Asn Gly Thr Asp Thr Gly 
    50                  55                  60                  


Leu Leu Gln Pro Ala Leu Ala His Gly Leu Ala Leu Gly Leu Val Ile 
65                  70                  75                  80  


Ala Thr Leu Gly Asn Ile Ser Gly Gly His Phe Asn Pro Ala Val Ser 
                85                  90                  95      


Leu Ala Ala Met Leu Ile Gly Gly Leu Asn Leu Val Met Leu Leu Pro 
            100                 105                 110         


Tyr Trp Val Ser Gln Leu Leu Gly Gly Met Leu Gly Ala Ala Leu Ala 
        115                 120                 125             


Lys Ala Val Ser Pro Glu Glu Arg Phe Trp Asn Ala Ser Gly Ala Ala 
    130                 135                 140                 


Phe Val Thr Val Gln Glu Gln Gly Gln Val Ala Gly Ala Leu Val Ala 
145                 150                 155                 160 


Glu Ile Ile Leu Thr Thr Leu Leu Ala Leu Ala Val Cys Met Gly Ala 
                165                 170                 175     


Ile Asn Glu Lys Thr Lys Gly Pro Leu Ala Pro Phe Ser Ile Gly Phe 
            180                 185                 190         


Ala Val Thr Val Asp Ile Leu Ala Gly Gly Pro Val Ser Gly Gly Cys 
        195                 200                 205             


Met Asn Pro Ala Arg Ala Phe Gly Pro Ala Val Val Ala Asn His Trp 
    210                 215                 220                 


Asn Phe His Trp Ile Tyr Trp Leu Gly Pro Leu Leu Ala Gly Leu Leu 
225                 230                 235                 240 


Val Gly Leu Leu Ile Arg Cys Phe Ile Gly Asp Gly Lys Thr Arg Leu 
                245                 250                 255     


Ile Leu Lys Ala Arg 
            260     


<210>  684
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQP9__Homo_sapiens__NP_066190

<400>  684

Met Gln Pro Glu Gly Ala Glu Lys Gly Lys Ser Phe Lys Gln Arg Leu 
1               5                   10                  15      


Val Leu Lys Ser Ser Leu Ala Lys Glu Thr Leu Ser Glu Phe Leu Gly 
            20                  25                  30          


Thr Phe Ile Leu Ile Val Leu Gly Cys Gly Cys Val Ala Gln Ala Ile 
        35                  40                  45              


Leu Ser Arg Gly Arg Phe Gly Gly Val Ile Thr Ile Asn Val Gly Phe 
    50                  55                  60                  


Ser Met Ala Val Ala Met Ala Ile Tyr Val Ala Gly Gly Val Ser Gly 
65                  70                  75                  80  


Gly His Ile Asn Pro Ala Val Ser Leu Ala Met Cys Leu Phe Gly Arg 
                85                  90                  95      


Met Lys Trp Phe Lys Leu Pro Phe Tyr Val Gly Ala Gln Phe Leu Gly 
            100                 105                 110         


Ala Phe Val Gly Ala Ala Thr Val Phe Gly Ile Tyr Tyr Asp Gly Leu 
        115                 120                 125             


Met Ser Phe Ala Gly Gly Lys Leu Leu Ile Val Gly Glu Asn Ala Thr 
    130                 135                 140                 


Ala His Ile Phe Ala Thr Tyr Pro Ala Pro Tyr Leu Ser Leu Ala Asn 
145                 150                 155                 160 


Ala Phe Ala Asp Gln Val Val Ala Thr Met Ile Leu Leu Ile Ile Val 
                165                 170                 175     


Phe Ala Ile Phe Asp Ser Arg Asn Leu Gly Ala Pro Arg Gly Leu Glu 
            180                 185                 190         


Pro Ile Ala Ile Gly Leu Leu Ile Ile Val Ile Ala Ser Ser Leu Gly 
        195                 200                 205             


Leu Asn Ser Gly Cys Ala Met Asn Pro Ala Arg Asp Leu Ser Pro Arg 
    210                 215                 220                 


Leu Phe Thr Ala Leu Ala Gly Trp Gly Phe Glu Val Phe Arg Ala Gly 
225                 230                 235                 240 


Asn Asn Phe Trp Trp Ile Pro Val Val Gly Pro Leu Val Gly Ala Val 
                245                 250                 255     


Ile Gly Gly Leu Ile Tyr Val Leu Val Ile Glu Ile His His Pro Glu 
            260                 265                 270         


Pro Asp Ser Val Phe Lys Thr Glu Gln Ser Glu Asp Lys Pro Glu Lys 
        275                 280                 285             


Tyr Glu Leu Ser Val Ile Met 
    290                 295 


<210>  685
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARAF__Homo_sapiens__NP_001243126

<400>  685

Met Glu Pro Pro Arg Gly Pro Pro Ala Asn Gly Ala Glu Pro Ser Arg 
1               5                   10                  15      


Ala Val Gly Thr Val Lys Val Tyr Leu Pro Asn Lys Gln Arg Thr Val 
            20                  25                  30          


Val Thr Val Arg Asp Gly Met Ser Val Tyr Asp Ser Leu Asp Lys Ala 
        35                  40                  45              


Leu Lys Val Arg Gly Leu Asn Gln Asp Cys Cys Val Val Tyr Arg Leu 
    50                  55                  60                  


Ile Lys Gly Arg Lys Thr Val Thr Ala Trp Asp Thr Ala Ile Ala Pro 
65                  70                  75                  80  


Leu Asp Gly Glu Glu Leu Ile Val Glu Val Leu Glu Asp Val Pro Leu 
                85                  90                  95      


Thr Met His Asn Phe Val Arg Lys Thr Phe Phe Ser Leu Ala Phe Cys 
            100                 105                 110         


Asp Phe Cys Leu Lys Phe Leu Phe His Gly Phe Arg Cys Gln Thr Cys 
        115                 120                 125             


Gly Tyr Lys Phe His Gln His Cys Ser Ser Lys Val Pro Thr Val Cys 
    130                 135                 140                 


Val Asp Met Ser Thr Asn Arg Gln Gln Phe Tyr His Ser Val Gln Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Ser Arg Gln His Glu Ala Pro Ser Asn Arg Pro Leu 
                165                 170                 175     


Asn Glu Leu Leu Thr Pro Gln Gly Pro Arg 
            180                 185     


<210>  686
<211>  1450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARAP1__Homo_sapiens__NP_001035207

<400>  686

Met Ala Glu Ala Gly Asp Ala Ala Leu Ser Val Ala Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu His Leu Glu Gln Tyr Thr Gly Leu Phe Glu Gln His Gly Leu 
            20                  25                  30          


Val Trp Ala Thr Glu Cys Gln Gly Leu Ser Asp Thr Arg Leu Met Asp 
        35                  40                  45              


Met Gly Met Leu Leu Pro Gly His Arg Arg Arg Ile Leu Ala Gly Leu 
    50                  55                  60                  


Leu Arg Ala His Thr Ser Pro Ala Pro Ala Pro Arg Pro Thr Pro Arg 
65                  70                  75                  80  


Pro Val Pro Met Lys Arg His Ile Phe Arg Ser Pro Pro Val Pro Ala 
                85                  90                  95      


Thr Pro Pro Glu Pro Leu Pro Thr Thr Thr Glu Asp Glu Gly Leu Pro 
            100                 105                 110         


Ala Ala Pro Pro Ile Pro Pro Arg Arg Ser Cys Leu Pro Pro Thr Cys 
        115                 120                 125             


Phe Thr Thr Pro Ser Thr Ala Ala Pro Asp Pro Val Leu Pro Pro Leu 
    130                 135                 140                 


Pro Ala Lys Arg His Leu Ala Glu Leu Ser Val Pro Pro Val Pro Pro 
145                 150                 155                 160 


Arg Thr Gly Pro Pro Arg Leu Leu Val Ser Leu Pro Thr Lys Glu Glu 
                165                 170                 175     


Glu Ser Leu Leu Pro Ser Leu Ser Ser Pro Pro Gln Pro Gln Ser Glu 
            180                 185                 190         


Glu Pro Leu Ser Thr Leu Pro Gln Gly Pro Pro Gln Pro Pro Ser Pro 
        195                 200                 205             


Pro Pro Cys Pro Pro Glu Ile Pro Pro Lys Pro Val Arg Leu Phe Pro 
    210                 215                 220                 


Glu Phe Asp Asp Ser Asp Tyr Asp Glu Val Pro Glu Glu Gly Pro Gly 
225                 230                 235                 240 


Ala Pro Ala Arg Val Met Thr Lys Lys Glu Glu Pro Pro Pro Ser Arg 
                245                 250                 255     


Val Pro Arg Ala Val Arg Val Ala Ser Leu Leu Ser Glu Gly Glu Glu 
            260                 265                 270         


Leu Ser Gly Asp Asp Gln Gly Asp Glu Glu Glu Asp Asp His Ala Tyr 
        275                 280                 285             


Glu Gly Val Pro Asn Gly Gly Trp His Thr Ser Ser Leu Ser Leu Ser 
    290                 295                 300                 


Leu Pro Ser Thr Ile Ala Ala Pro His Pro Met Asp Gly Pro Pro Gly 
305                 310                 315                 320 


Gly Ser Thr Pro Val Thr Pro Val Ile Lys Ala Gly Trp Leu Asp Lys 
                325                 330                 335     


Asn Pro Pro Gln Gly Ser Tyr Ile Tyr Gln Lys Arg Trp Val Arg Leu 
            340                 345                 350         


Asp Thr Asp His Leu Arg Tyr Phe Asp Ser Asn Lys Asp Ala Tyr Ser 
        355                 360                 365             


Lys Arg Phe Ile Ser Val Ala Cys Ile Ser His Val Ala Ala Ile Gly 
    370                 375                 380                 


Asp Gln Lys Phe Glu Val Ile Thr Asn Asn Arg Thr Phe Ala Phe Arg 
385                 390                 395                 400 


Ala Glu Ser Asp Val Glu Arg Lys Glu Trp Met Gln Ala Leu Gln Gln 
                405                 410                 415     


Ala Met Ala Glu Gln Arg Ala Arg Ala Arg Leu Ser Ser Ala Tyr Leu 
            420                 425                 430         


Leu Gly Val Pro Gly Ser Glu Gln Pro Asp Arg Ala Gly Ser Leu Glu 
        435                 440                 445             


Leu Arg Gly Phe Lys Asn Lys Leu Tyr Val Ala Val Val Gly Asp Lys 
    450                 455                 460                 


Val Gln Leu Tyr Lys Asn Leu Glu Glu Tyr His Leu Gly Ile Gly Ile 
465                 470                 475                 480 


Thr Phe Ile Asp Met Ser Val Gly Asn Val Lys Glu Val Asp Arg Arg 
                485                 490                 495     


Ser Phe Asp Leu Thr Thr Pro Tyr Arg Ile Phe Ser Phe Ser Ala Asp 
            500                 505                 510         


Ser Glu Leu Glu Lys Glu Gln Trp Leu Glu Ala Met Gln Gly Ala Ile 
        515                 520                 525             


Ala Glu Ala Leu Ser Thr Ser Glu Val Ala Glu Arg Ile Trp Ala Ala 
    530                 535                 540                 


Ala Pro Asn Arg Phe Cys Ala Asp Cys Gly Ala Pro Gln Pro Asp Trp 
545                 550                 555                 560 


Ala Ser Ile Asn Leu Cys Val Val Ile Cys Lys Arg Cys Ala Gly Glu 
                565                 570                 575     


His Arg Gly Leu Gly Ala Gly Val Ser Lys Val Arg Ser Leu Lys Met 
            580                 585                 590         


Asp Arg Lys Val Trp Thr Glu Thr Leu Ile Glu Leu Phe Leu Gln Leu 
        595                 600                 605             


Gly Asn Gly Ala Gly Asn Arg Phe Trp Ala Ala Asn Val Pro Pro Ser 
    610                 615                 620                 


Glu Ala Leu Gln Pro Ser Ser Ser Pro Ser Thr Arg Arg Cys His Leu 
625                 630                 635                 640 


Glu Ala Lys Tyr Arg Glu Gly Lys Tyr Arg Arg Tyr His Pro Leu Phe 
                645                 650                 655     


Gly Asn Gln Glu Glu Leu Asp Lys Ala Leu Cys Ala Ala Val Thr Thr 
            660                 665                 670         


Thr Asp Leu Ala Glu Thr Gln Ala Leu Leu Gly Cys Gly Ala Gly Ile 
        675                 680                 685             


Asn Cys Phe Ser Gly Asp Pro Glu Ala Pro Thr Pro Leu Ala Leu Ala 
    690                 695                 700                 


Glu Gln Ala Gly Gln Thr Leu Gln Met Glu Phe Leu Arg Asn Asn Arg 
705                 710                 715                 720 


Thr Thr Glu Val Pro Arg Leu Asp Ser Met Lys Pro Leu Glu Lys His 
                725                 730                 735     


Tyr Ser Val Val Leu Pro Thr Val Ser His Ser Gly Phe Leu Tyr Lys 
            740                 745                 750         


Thr Ala Ser Ala Gly Lys Leu Leu Gln Asp Arg Arg Ala Arg Glu Glu 
        755                 760                 765             


Phe Ser Arg Arg Trp Cys Val Leu Gly Asp Gly Val Leu Ser Tyr Phe 
    770                 775                 780                 


Glu Asn Glu Arg Ala Val Thr Pro Asn Gly Glu Ile Arg Ala Ser Glu 
785                 790                 795                 800 


Ile Val Cys Leu Ala Val Pro Pro Pro Asp Thr His Gly Phe Glu His 
                805                 810                 815     


Thr Phe Glu Val Tyr Thr Glu Gly Glu Arg Leu Tyr Leu Phe Gly Leu 
            820                 825                 830         


Glu Ser Ala Glu Gln Ala His Glu Trp Val Lys Cys Ile Ala Lys Ala 
        835                 840                 845             


Phe Val Pro Pro Leu Ala Glu Asp Leu Leu Ala Arg Asp Phe Glu Arg 
    850                 855                 860                 


Leu Gly Arg Leu Pro Tyr Lys Ala Gly Leu Ser Leu Gln Arg Ala Gln 
865                 870                 875                 880 


Glu Gly Trp Phe Ser Leu Ser Gly Ser Glu Leu Arg Ala Val Phe Pro 
                885                 890                 895     


Glu Gly Pro Cys Glu Glu Pro Leu Gln Leu Arg Lys Leu Gln Glu Leu 
            900                 905                 910         


Ser Ile Gln Gly Asp Ser Glu Asn Gln Val Leu Val Leu Val Glu Arg 
        915                 920                 925             


Arg Arg Thr Leu Tyr Ile Gln Gly Glu Arg Arg Leu Asp Phe Met Gly 
    930                 935                 940                 


Trp Leu Gly Ala Ile Gln Lys Ala Ala Ala Ser Met Gly Asp Thr Leu 
945                 950                 955                 960 


Ser Glu Gln Gln Leu Gly Asp Ser Asp Ile Pro Val Ile Val Tyr Arg 
                965                 970                 975     


Cys Val Asp Tyr Ile Thr Gln Cys Gly Leu Thr Ser Glu Gly Ile Tyr 
            980                 985                 990         


Arg Lys Cys Gly Gln Thr Ser Lys  Thr Gln Arg Leu Leu  Glu Ser Leu 
        995                 1000                 1005             


Arg Gln  Asp Ala Arg Ser Val  His Leu Lys Glu Gly  Glu Gln His 
    1010                 1015                 1020             


Val Asp  Asp Val Ser Ser Ala  Leu Lys Arg Phe Leu  Arg Asp Leu 
    1025                 1030                 1035             


Pro Asp  Gly Leu Phe Thr Arg  Ala Gln Arg Leu Thr  Trp Leu Glu 
    1040                 1045                 1050             


Ala Ser  Glu Ile Glu Asp Glu  Glu Glu Lys Val Ser  Arg Tyr Arg 
    1055                 1060                 1065             


Glu Leu  Leu Val Arg Leu Pro  Pro Val Asn Arg Ala  Thr Val Lys 
    1070                 1075                 1080             


Ala Leu  Ile Ser His Leu Tyr  Cys Val Gln Cys Phe  Ser Asp Thr 
    1085                 1090                 1095             


Asn Gln  Met Asn Val His Asn  Leu Ala Ile Val Phe  Gly Pro Thr 
    1100                 1105                 1110             


Leu Phe  Gln Thr Asp Gly Gln  Asp Tyr Lys Ala Gly  Arg Val Val 
    1115                 1120                 1125             


Glu Asp  Leu Ile Asn His Tyr  Val Val Val Phe Ser  Val Asp Glu 
    1130                 1135                 1140             


Glu Glu  Leu Arg Lys Gln Arg  Glu Glu Ile Thr Ala  Ile Val Lys 
    1145                 1150                 1155             


Met Arg  Val Ala Gly Thr Ala  Ser Gly Thr Gln His  Ala Gly Asp 
    1160                 1165                 1170             


Phe Ile  Cys Thr Val Tyr Leu  Glu Glu Lys Lys Ala  Glu Thr Glu 
    1175                 1180                 1185             


Gln His  Ile Lys Val Pro Ala  Ser Met Thr Ala Glu  Glu Leu Thr 
    1190                 1195                 1200             


Leu Glu  Ile Leu Asp Arg Arg  Asn Val Gly Ile Arg  Glu Lys Asp 
    1205                 1210                 1215             


Tyr Trp  Thr Cys Phe Glu Val  Asn Glu Arg Glu Glu  Ala Glu Arg 
    1220                 1225                 1230             


Pro Leu  His Phe Ala Glu Lys  Val Leu Pro Ile Leu  His Gly Leu 
    1235                 1240                 1245             


Gly Thr  Asp Ser His Leu Val  Val Lys Lys His Gln  Ala Met Glu 
    1250                 1255                 1260             


Ala Met  Leu Leu Tyr Leu Ala  Ser Arg Val Gly Asp  Thr Lys His 
    1265                 1270                 1275             


Gly Met  Met Lys Phe Arg Glu  Asp Arg Ser Leu Leu  Gly Leu Gly 
    1280                 1285                 1290             


Leu Pro  Ser Gly Gly Phe His  Asp Arg Tyr Phe Ile  Leu Asn Ser 
    1295                 1300                 1305             


Ser Cys  Leu Arg Leu Tyr Lys  Glu Val Arg Ser Gln  Arg Pro Trp 
    1310                 1315                 1320             


Ser Gly  Ala Pro Glu Thr Ser  His Arg Pro Glu Lys  Glu Trp Pro 
    1325                 1330                 1335             


Ile Lys  Ser Leu Lys Val Tyr  Leu Gly Val Lys Lys  Lys Leu Arg 
    1340                 1345                 1350             


Pro Pro  Thr Cys Trp Gly Phe  Thr Val Val His Glu  Thr Glu Lys 
    1355                 1360                 1365             


His Glu  Lys Gln Gln Trp Tyr  Leu Cys Cys Asp Thr  Gln Met Glu 
    1370                 1375                 1380             


Leu Arg  Glu Trp Phe Ala Thr  Phe Leu Phe Val Gln  His Asp Gly 
    1385                 1390                 1395             


Leu Val  Trp Pro Ser Glu Pro  Ser Arg Val Ser Arg  Ala Val Pro 
    1400                 1405                 1410             


Glu Val  Arg Leu Gly Ser Val  Ser Leu Ile Pro Leu  Arg Gly Ser 
    1415                 1420                 1425             


Glu Asn  Glu Met Arg Arg Ser  Val Ala Ala Phe Thr  Ala Asp Pro 
    1430                 1435                 1440             


Leu Ser  Leu Leu Arg Asn Val  
    1445                 1450 


<210>  687
<211>  1544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARAP3__Homo_sapiens__NP_071926

<400>  687

Met Ala Ala Pro Gln Asp Leu Asp Ile Ala Val Trp Leu Ala Thr Val 
1               5                   10                  15      


His Leu Glu Gln Tyr Ala Asp Thr Phe Arg Arg His Gly Leu Ala Thr 
            20                  25                  30          


Ala Gly Ala Ala Arg Gly Leu Gly His Glu Glu Leu Lys Gln Leu Gly 
        35                  40                  45              


Ile Ser Ala Thr Gly His Arg Lys Arg Ile Leu Arg Leu Leu Gln Thr 
    50                  55                  60                  


Gly Thr Glu Glu Gly Ser Leu Asp Pro Lys Ser Asp Ser Ala Met Glu 
65                  70                  75                  80  


Pro Ser Pro Ser Pro Ala Pro Gln Ala Gln Pro Pro Lys Pro Val Pro 
                85                  90                  95      


Lys Pro Arg Thr Val Phe Gly Gly Leu Ser Gly Pro Ala Thr Thr Gln 
            100                 105                 110         


Arg Pro Gly Leu Ser Pro Ala Leu Gly Gly Pro Gly Val Ser Arg Ser 
        115                 120                 125             


Pro Glu Pro Ser Pro Arg Pro Pro Pro Leu Pro Thr Ser Ser Ser Glu 
    130                 135                 140                 


Gln Ser Ser Ala Leu Asn Thr Val Glu Met Met Pro Asn Ser Ile Tyr 
145                 150                 155                 160 


Phe Gly Leu Asp Ser Arg Gly Arg Ala Gln Ala Ala Gln Asp Lys Ala 
                165                 170                 175     


Pro Asp Ser Ser Gln Ile Ser Ala Pro Thr Pro Ala Leu Arg Pro Thr 
            180                 185                 190         


Thr Gly Thr Val His Ile Met Asp Pro Gly Cys Leu Tyr Tyr Gly Val 
        195                 200                 205             


Gln Pro Val Gly Thr Pro Gly Ala Pro Asp Arg Arg Glu Ser Arg Gly 
    210                 215                 220                 


Val Cys Gln Gly Arg Ala Glu His Arg Leu Ser Arg Gln Asp Leu Glu 
225                 230                 235                 240 


Ala Arg Glu Asp Ala Gly Tyr Ala Ser Leu Glu Leu Pro Gly Asp Ser 
                245                 250                 255     


Thr Leu Leu Ser Pro Thr Leu Glu Thr Glu Glu Thr Ser Asp Asp Leu 
            260                 265                 270         


Ile Ser Pro Tyr Ala Ser Phe Ser Phe Thr Ala Asp Arg Leu Thr Pro 
        275                 280                 285             


Leu Leu Ser Gly Trp Leu Asp Lys Leu Ser Pro Gln Gly Asn Tyr Val 
    290                 295                 300                 


Phe Gln Arg Arg Phe Val Gln Phe Asn Gly Arg Ser Leu Met Tyr Phe 
305                 310                 315                 320 


Gly Ser Asp Lys Asp Pro Phe Pro Lys Gly Val Ile Pro Leu Thr Ala 
                325                 330                 335     


Ile Glu Met Thr Arg Ser Ser Lys Asp Asn Lys Phe Gln Val Ile Thr 
            340                 345                 350         


Gly Gln Arg Val Phe Val Phe Arg Thr Glu Ser Glu Ala Gln Arg Asp 
        355                 360                 365             


Met Trp Cys Ser Thr Leu Gln Ser Cys Leu Lys Glu Gln Arg Leu Leu 
    370                 375                 380                 


Gly His Pro Arg Pro Pro Gln Pro Pro Arg Pro Leu Arg Thr Gly Met 
385                 390                 395                 400 


Leu Glu Leu Arg Gly His Lys Ala Lys Val Phe Ala Ala Leu Ser Pro 
                405                 410                 415     


Gly Glu Leu Ala Leu Tyr Lys Ser Glu Gln Ala Phe Ser Leu Gly Ile 
            420                 425                 430         


Gly Ile Cys Phe Ile Glu Leu Gln Gly Cys Ser Val Arg Glu Thr Lys 
        435                 440                 445             


Ser Arg Ser Phe Asp Leu Leu Thr Pro His Arg Cys Phe Ser Phe Thr 
    450                 455                 460                 


Ala Glu Ser Gly Gly Ala Arg Gln Ser Trp Ala Ala Ala Leu Gln Glu 
465                 470                 475                 480 


Ala Val Thr Glu Thr Leu Ser Asp Tyr Glu Val Ala Glu Lys Ile Trp 
                485                 490                 495     


Ser Asn Arg Ala Asn Arg Gln Cys Ala Asp Cys Gly Ser Ser Arg Pro 
            500                 505                 510         


Asp Trp Ala Ala Val Asn Leu Gly Val Val Ile Cys Lys Gln Cys Ala 
        515                 520                 525             


Gly Gln His Arg Ala Leu Gly Ser Gly Ile Ser Lys Val Gln Ser Leu 
    530                 535                 540                 


Lys Leu Asp Thr Ser Val Trp Ser Asn Glu Ile Val Gln Leu Phe Ile 
545                 550                 555                 560 


Val Leu Gly Asn Asp Arg Ala Asn Arg Phe Trp Ala Gly Thr Leu Pro 
                565                 570                 575     


Pro Gly Glu Gly Leu His Pro Asp Ala Thr Pro Gly Pro Arg Gly Glu 
            580                 585                 590         


Phe Ile Ser Arg Lys Tyr Arg Leu Gly Leu Phe Arg Lys Pro His Pro 
        595                 600                 605             


Gln Tyr Pro Asp His Ser Gln Leu Leu Gln Ala Leu Cys Ala Ala Val 
    610                 615                 620                 


Ala Arg Pro Asn Leu Leu Lys Asn Met Thr Gln Leu Leu Cys Val Glu 
625                 630                 635                 640 


Ala Phe Glu Gly Glu Glu Pro Trp Phe Pro Pro Ala Pro Asp Gly Ser 
                645                 650                 655     


Cys Pro Gly Leu Leu Pro Ser Asp Pro Ser Pro Gly Val Tyr Asn Glu 
            660                 665                 670         


Val Val Val Arg Ala Thr Tyr Ser Gly Phe Leu Tyr Cys Ser Pro Val 
        675                 680                 685             


Ser Asn Lys Ala Gly Pro Ser Pro Pro Arg Arg Gly Arg Asp Ala Pro 
    690                 695                 700                 


Pro Arg Leu Trp Cys Val Leu Gly Ala Ala Leu Glu Met Phe Ala Ser 
705                 710                 715                 720 


Glu Asn Ser Pro Glu Pro Leu Ser Leu Ile Gln Pro Gln Asp Ile Val 
                725                 730                 735     


Cys Leu Gly Val Ser Pro Pro Pro Thr Asp Pro Gly Asp Arg Phe Pro 
            740                 745                 750         


Phe Ser Phe Glu Leu Ile Leu Ala Gly Gly Arg Ile Gln His Phe Gly 
        755                 760                 765             


Thr Asp Gly Ala Asp Ser Leu Glu Ala Trp Thr Ser Ala Val Gly Lys 
    770                 775                 780                 


Trp Phe Ser Pro Leu Ser Cys His Gln Leu Leu Gly Pro Gly Leu Leu 
785                 790                 795                 800 


Arg Leu Gly Arg Leu Trp Leu Arg Ser Pro Ser His Thr Ala Pro Ala 
                805                 810                 815     


Pro Gly Leu Trp Leu Ser Gly Phe Gly Leu Leu Arg Gly Asp His Leu 
            820                 825                 830         


Phe Leu Cys Ser Ala Pro Gly Pro Gly Pro Pro Ala Pro Glu Asp Met 
        835                 840                 845             


Val His Leu Arg Arg Leu Gln Glu Ile Ser Val Val Ser Ala Ala Asp 
    850                 855                 860                 


Thr Pro Asp Lys Lys Glu His Leu Val Leu Val Glu Thr Gly Arg Thr 
865                 870                 875                 880 


Leu Tyr Leu Gln Gly Glu Gly Arg Leu Asp Phe Thr Ala Trp Asn Ala 
                885                 890                 895     


Ala Ile Gly Gly Ala Ala Gly Gly Gly Gly Thr Gly Leu Gln Glu Gln 
            900                 905                 910         


Gln Met Ser Arg Gly Asp Ile Pro Ile Ile Val Asp Ala Cys Ile Ser 
        915                 920                 925             


Phe Val Thr Gln His Gly Leu Arg Leu Glu Gly Val Tyr Arg Lys Gly 
    930                 935                 940                 


Gly Ala Arg Ala Arg Ser Leu Arg Leu Leu Ala Glu Phe Arg Arg Asp 
945                 950                 955                 960 


Ala Arg Ser Val Lys Leu Arg Pro Gly Glu His Phe Val Glu Asp Val 
                965                 970                 975     


Thr Asp Thr Leu Lys Arg Phe Phe Arg Glu Leu Asp Asp Pro Val Thr 
            980                 985                 990         


Ser Ala Arg Leu Leu Pro Arg Trp  Arg Glu Ala Ala Glu  Leu Pro Gln 
        995                 1000                 1005             


Lys Asn  Gln Arg Leu Glu Lys  Tyr Lys Asp Val Ile  Gly Cys Leu 
    1010                 1015                 1020             


Pro Arg  Val Asn Arg Arg Thr  Leu Ala Thr Leu Ile  Gly His Leu 
    1025                 1030                 1035             


Tyr Arg  Val Gln Lys Cys Ala  Ala Leu Asn Gln Met  Cys Thr Arg 
    1040                 1045                 1050             


Asn Leu  Ala Leu Leu Phe Ala  Pro Ser Val Phe Gln  Thr Asp Gly 
    1055                 1060                 1065             


Arg Gly  Glu His Glu Val Arg  Val Leu Gln Glu Leu  Ile Asp Gly 
    1070                 1075                 1080             


Tyr Ile  Ser Val Phe Asp Ile  Asp Ser Asp Gln Val  Ala Gln Ile 
    1085                 1090                 1095             


Asp Leu  Glu Val Ser Leu Ile  Thr Thr Trp Lys Asp  Val Gln Leu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Asp Leu Ile  Met Glu Val Tyr Ile  Glu Gln Gln 
    1115                 1120                 1125             


Leu Pro  Asp Asn Cys Val Thr  Leu Lys Val Ser Pro  Thr Leu Thr 
    1130                 1135                 1140             


Ala Glu  Glu Leu Thr Asn Gln  Val Leu Glu Met Arg  Gly Thr Ala 
    1145                 1150                 1155             


Ala Gly  Met Asp Leu Trp Val  Thr Phe Glu Ile Arg  Glu His Gly 
    1160                 1165                 1170             


Glu Leu  Glu Arg Pro Leu His  Pro Lys Glu Lys Val  Leu Glu Gln 
    1175                 1180                 1185             


Ala Leu  Gln Trp Cys Gln Leu  Pro Glu Pro Cys Ser  Ala Ser Leu 
    1190                 1195                 1200             


Leu Leu  Lys Lys Val Pro Leu  Ala Gln Ala Gly Cys  Leu Phe Thr 
    1205                 1210                 1215             


Gly Ile  Arg Arg Glu Ser Pro  Arg Val Gly Leu Leu  Arg Cys Arg 
    1220                 1225                 1230             


Glu Glu  Pro Pro Arg Leu Leu  Gly Ser Arg Phe Gln  Glu Arg Phe 
    1235                 1240                 1245             


Phe Leu  Leu Arg Gly Arg Cys  Leu Leu Leu Leu Lys  Glu Lys Lys 
    1250                 1255                 1260             


Ser Ser  Lys Pro Glu Arg Glu  Trp Pro Leu Glu Gly  Ala Lys Val 
    1265                 1270                 1275             


Tyr Leu  Gly Ile Arg Lys Lys  Leu Lys Pro Pro Thr  Pro Trp Gly 
    1280                 1285                 1290             


Phe Thr  Leu Ile Leu Glu Lys  Met His Leu Tyr Leu  Ser Cys Thr 
    1295                 1300                 1305             


Asp Glu  Asp Glu Met Trp Asp  Trp Thr Thr Ser Ile  Leu Lys Ala 
    1310                 1315                 1320             


Gln His  Asp Asp Gln Gln Pro  Val Val Leu Arg Arg  His Ser Ser 
    1325                 1330                 1335             


Ser Asp  Leu Ala Arg Gln Lys  Phe Gly Thr Met Pro  Leu Leu Pro 
    1340                 1345                 1350             


Ile Arg  Gly Asp Asp Ser Gly  Ala Thr Leu Leu Ser  Ala Asn Gln 
    1355                 1360                 1365             


Thr Leu  Arg Arg Leu His Asn  Arg Arg Thr Leu Ser  Met Phe Phe 
    1370                 1375                 1380             


Pro Met  Lys Ser Ser Gln Gly  Ser Val Glu Glu Gln  Glu Glu Leu 
    1385                 1390                 1395             


Glu Glu  Pro Val Tyr Glu Glu  Pro Val Tyr Glu Glu  Val Gly Ala 
    1400                 1405                 1410             


Phe Pro  Glu Leu Ile Gln Asp  Thr Ser Thr Ser Phe  Ser Thr Thr 
    1415                 1420                 1425             


Arg Glu  Trp Thr Val Lys Pro  Glu Asn Pro Leu Thr  Ser Gln Lys 
    1430                 1435                 1440             


Ser Leu  Asp Gln Pro Phe Leu  Ser Lys Ser Ser Thr  Leu Gly Gln 
    1445                 1450                 1455             


Glu Glu  Arg Pro Pro Glu Pro  Pro Pro Gly Pro Pro  Ser Lys Ser 
    1460                 1465                 1470             


Ser Pro  Gln Ala Arg Gly Ser  Leu Glu Glu Gln Leu  Leu Gln Glu 
    1475                 1480                 1485             


Leu Ser  Ser Leu Ile Leu Arg  Lys Gly Glu Thr Thr  Ala Gly Leu 
    1490                 1495                 1500             


Gly Ser  Pro Ser Gln Pro Ser  Ser Pro Gln Ser Pro  Ser Pro Thr 
    1505                 1510                 1515             


Gly Leu  Pro Thr Gln Thr Pro  Gly Phe Pro Thr Gln  Pro Pro Cys 
    1520                 1525                 1530             


Thr Ser  Ser Pro Pro Ser Ser  Gln Pro Leu Thr 
    1535                 1540                 


<210>  688
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARC__Homo_sapiens__NP_056008

<400>  688

Met Glu Leu Asp His Arg Thr Ser Gly Gly Leu His Ala Tyr Pro Gly 
1               5                   10                  15      


Pro Arg Gly Gly Gln Val Ala Lys Pro Asn Val Ile Leu Gln Ile Gly 
            20                  25                  30          


Lys Cys Arg Ala Glu Met Leu Glu His Val Arg Arg Thr His Arg His 
        35                  40                  45              


Leu Leu Ala Glu Val Ser Lys Gln Val Glu Arg Glu Leu Lys Gly Leu 
    50                  55                  60                  


His Arg Ser Val Gly Lys Leu Glu Ser Asn Leu Asp Gly Tyr Val Pro 
65                  70                  75                  80  


Thr Ser Asp Ser Gln Arg Trp Lys Lys Ser Ile Lys Ala Cys Leu Cys 
                85                  90                  95      


Arg Cys Gln Glu Thr Ile Ala Asn Leu Glu Arg Trp Val Lys Arg Glu 
            100                 105                 110         


Met His Val Trp Arg Glu Val Phe Tyr Arg Leu Glu Arg Trp Ala Asp 
        115                 120                 125             


Arg Leu Glu Ser Thr Gly Gly Lys Tyr Pro Val Gly Ser Glu Ser Ala 
    130                 135                 140                 


Arg His Thr Val Ser Val Gly Val Gly Gly Pro Glu Ser Tyr Cys His 
145                 150                 155                 160 


Glu Ala Asp Gly Tyr Asp Tyr Thr Val Ser Pro Tyr Ala Ile Thr Pro 
                165                 170                 175     


Pro Pro Ala Ala Gly Glu Leu Pro Gly Gln Glu Pro Ala Glu Ala Gln 
            180                 185                 190         


Gln Tyr Gln Pro Trp Val Pro Gly Glu Asp Gly Gln Pro Ser Pro Gly 
        195                 200                 205             


Val Asp Thr Gln Ile Phe Glu Asp Pro Arg Glu Phe Leu Ser His Leu 
    210                 215                 220                 


Glu Glu Tyr Leu Arg Gln Val Gly Gly Ser Glu Glu Tyr Trp Leu Ser 
225                 230                 235                 240 


Gln Ile Gln Asn His Met Asn Gly Pro Ala Lys Lys Trp Trp Glu Phe 
                245                 250                 255     


Lys Gln Gly Ser Val Lys Asn Trp Val Glu Phe Lys Lys Glu Phe Leu 
            260                 265                 270         


Gln Tyr Ser Glu Gly Thr Leu Ser Arg Glu Ala Ile Gln Arg Glu Leu 
        275                 280                 285             


Asp Leu Pro Gln Lys Gln Gly Glu Pro Leu Asp Gln Phe Leu Trp Arg 
    290                 295                 300                 


Lys Arg Asp Leu Tyr Gln Thr Leu Tyr Val Asp Ala Asp Glu Glu Glu 
305                 310                 315                 320 


Ile Ile Gln Tyr Val Val Gly Thr Leu Gln Pro Lys Leu Lys Arg Phe 
                325                 330                 335     


Leu Arg His Pro Leu Pro Lys Thr Leu Glu Gln Leu Ile Gln Arg Gly 
            340                 345                 350         


Met Glu Val Gln Asp Asp Leu Glu Gln Ala Ala Glu Pro Ala Gly Pro 
        355                 360                 365             


His Leu Pro Val Glu Asp Glu Ala Glu Thr Leu Thr Pro Ala Pro Asn 
    370                 375                 380                 


Ser Glu Ser Val Ala Ser Asp Arg Thr Gln Pro Glu 
385                 390                 395     


<210>  689
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARCN1__Homo_sapiens__NP_001135753

<400>  689

Met Ile Pro Glu Tyr Cys Arg Ala Leu Glu Glu Asn Glu Ile Ser Glu 
1               5                   10                  15      


His Cys Phe Asp Leu Ile Phe Ala Phe Asp Glu Ile Val Ala Leu Gly 
            20                  25                  30          


Tyr Arg Glu Asn Val Asn Leu Ala Gln Ile Arg Thr Phe Thr Glu Met 
        35                  40                  45              


Asp Ser His Glu Glu Lys Val Phe Arg Ala Val Arg Glu Thr Gln Glu 
    50                  55                  60                  


Arg Glu Ala Lys Ala Glu Met Arg Arg Lys Ala Lys Glu Leu Gln Gln 
65                  70                  75                  80  


Ala Arg Arg Asp Ala Glu Arg Gln Gly Lys Lys Ala Pro Gly Phe Gly 
                85                  90                  95      


Gly Phe Gly Ser Ser Ala Val Ser Gly Gly Ser Thr Ala Ala Met Ile 
            100                 105                 110         


Thr Glu Thr Ile Ile Glu Thr Asp Lys Pro Lys Val Ala Pro Ala Pro 
        115                 120                 125             


Ala Arg Pro Ser Gly Pro Ser Lys Ala Leu Lys Leu Gly Ala Lys Gly 
    130                 135                 140                 


Lys Glu Val Asp Asn Phe Val Asp Lys Leu Lys Ser Glu Gly Glu Thr 
145                 150                 155                 160 


Ile Met Ser Ser Ser Met Gly Lys Arg Thr Ser Glu Ala Thr Lys Met 
                165                 170                 175     


His Ala Pro Pro Ile Asn Met Glu Ser Val His Met Lys Ile Glu Glu 
            180                 185                 190         


Lys Ile Thr Leu Thr Cys Gly Arg Asp Gly Gly Leu Gln Asn Met Glu 
        195                 200                 205             


Leu His Gly Met Ile Met Leu Arg Ile Ser Asp Asp Lys Tyr Gly Arg 
    210                 215                 220                 


Ile Arg Leu His Val Glu Asn Glu Asp Lys Lys Gly Val Gln Leu Gln 
225                 230                 235                 240 


Thr His Pro Asn Val Asp Lys Lys Leu Phe Thr Ala Glu Ser Leu Ile 
                245                 250                 255     


Gly Leu Lys Asn Pro Glu Lys Ser Phe Pro Val Asn Ser Asp Val Gly 
            260                 265                 270         


Val Leu Lys Trp Arg Leu Gln Thr Thr Glu Glu Ser Phe Ile Pro Leu 
        275                 280                 285             


Thr Ile Asn Cys Trp Pro Ser Glu Ser Gly Asn Gly Cys Asp Val Asn 
    290                 295                 300                 


Ile Glu Tyr Glu Leu Gln Glu Asp Asn Leu Glu Leu Asn Asp Val Val 
305                 310                 315                 320 


Ile Thr Ile Pro Leu Pro Ser Gly Val Gly Ala Pro Val Ile Gly Glu 
                325                 330                 335     


Ile Asp Gly Glu Tyr Arg His Asp Ser Arg Arg Asn Thr Leu Glu Trp 
            340                 345                 350         


Cys Leu Pro Val Ile Asp Ala Lys Asn Lys Ser Gly Ser Leu Glu Phe 
        355                 360                 365             


Ser Ile Ala Gly Gln Pro Asn Asp Phe Phe Pro Val Gln Val Ser Phe 
    370                 375                 380                 


Val Ser Lys Lys Asn Tyr Cys Asn Ile Gln Val Thr Lys Val Thr Gln 
385                 390                 395                 400 


Val Asp Gly Asn Ser Pro Val Arg Phe Ser Thr Glu Thr Thr Phe Leu 
                405                 410                 415     


Val Asp Lys Tyr Glu Ile Leu 
            420             


<210>  690
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AREG__Homo_sapiens__NP_001648

<400>  690

Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 
    210                 215                 220                 


Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                 230                 235                 240 


Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                 250         


<210>  691
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARF1__Homo_sapiens__NP_001019398

<400>  691

Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
65                  70                  75                  80  


Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 
            100                 105                 110         


Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 
    130                 135                 140                 


Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln 
                165                 170                 175     


Leu Arg Asn Gln Lys 
            180     


<210>  692
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARF3__Homo_sapiens__NP_001650

<400>  692

Met Gly Asn Ile Phe Gly Asn Leu Leu Lys Ser Leu Ile Gly Lys Lys 
1               5                   10                  15      


Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His 
65                  70                  75                  80  


Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala 
            100                 105                 110         


Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly 
    130                 135                 140                 


Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ala Asn Gln 
                165                 170                 175     


Leu Lys Asn Lys Lys 
            180     


<210>  693
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARF4__Homo_sapiens__NP_001651

<400>  693

Met Gly Leu Thr Ile Ser Ser Leu Phe Ser Arg Leu Phe Gly Lys Lys 
1               5                   10                  15      


Gln Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Cys Phe Thr 
    50                  55                  60                  


Val Trp Asp Val Gly Gly Gln Asp Arg Ile Arg Pro Leu Trp Lys His 
65                  70                  75                  80  


Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp 
                85                  90                  95      


Arg Glu Arg Ile Gln Glu Val Ala Asp Glu Leu Gln Lys Met Leu Leu 
            100                 105                 110         


Val Asp Glu Leu Arg Asp Ala Val Leu Leu Leu Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Pro Asn Ala Met Ala Ile Ser Glu Met Thr Asp Lys Leu Gly 
    130                 135                 140                 


Leu Gln Ser Leu Arg Asn Arg Thr Trp Tyr Val Gln Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Gln Gly Thr Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Glu 
                165                 170                 175     


Leu Ser Lys Arg 
            180 


<210>  694
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARF6__Homo_sapiens__NP_001654

<400>  694

Met Gly Lys Val Leu Ser Lys Ile Phe Gly Asn Lys Glu Met Arg Ile 
1               5                   10                  15      


Leu Met Leu Gly Leu Asp Ala Ala Gly Lys Thr Thr Ile Leu Tyr Lys 
            20                  25                  30          


Leu Lys Leu Gly Gln Ser Val Thr Thr Ile Pro Thr Val Gly Phe Asn 
        35                  40                  45              


Val Glu Thr Val Thr Tyr Lys Asn Val Lys Phe Asn Val Trp Asp Val 
    50                  55                  60                  


Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His Tyr Tyr Thr Gly 
65                  70                  75                  80  


Thr Gln Gly Leu Ile Phe Val Val Asp Cys Ala Asp Arg Asp Arg Ile 
                85                  90                  95      


Asp Glu Ala Arg Gln Glu Leu His Arg Ile Ile Asn Asp Arg Glu Met 
            100                 105                 110         


Arg Asp Ala Ile Ile Leu Ile Phe Ala Asn Lys Gln Asp Leu Pro Asp 
        115                 120                 125             


Ala Met Lys Pro His Glu Ile Gln Glu Lys Leu Gly Leu Thr Arg Ile 
    130                 135                 140                 


Arg Asp Arg Asn Trp Tyr Val Gln Pro Ser Cys Ala Thr Ser Gly Asp 
145                 150                 155                 160 


Gly Leu Tyr Glu Gly Leu Thr Trp Leu Thr Ser Asn Tyr Lys Ser 
                165                 170                 175 


<210>  695
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFGAP1__Homo_sapiens__NP_001268411

<400>  695

Met Ala Ser Pro Arg Thr Arg Lys Val Leu Lys Glu Val Arg Val Gln 
1               5                   10                  15      


Asp Glu Asn Asn Val Cys Phe Glu Cys Gly Ala Phe Asn Pro Gln Trp 
            20                  25                  30          


Val Ser Val Thr Tyr Gly Ile Trp Ile Cys Leu Glu Cys Ser Gly Arg 
        35                  40                  45              


His Arg Gly Leu Gly Val His Leu Ser Phe Val Arg Ser Val Thr Met 
    50                  55                  60                  


Asp Lys Trp Lys Asp Ile Glu Leu Glu Lys Met Lys Ala Gly Gly Asn 
65                  70                  75                  80  


Ala Lys Phe Arg Glu Phe Leu Glu Ser Gln Glu Asp Tyr Asp Pro Cys 
                85                  90                  95      


Trp Ser Leu Gln Glu Lys Tyr Asn Ser Arg Ala Ala Ala Leu Phe Arg 
            100                 105                 110         


Asp Lys Val Val Ala Leu Ala Glu Gly Arg Glu Trp Ser Leu Glu Ser 
        115                 120                 125             


Ser Pro Ala Gln Asn Trp Thr Pro Pro Gln Pro Arg Thr Leu Pro Ser 
    130                 135                 140                 


Met Val His Arg Val Ser Gly Gln Pro Gln Ser Val Thr Ala Ser Ser 
145                 150                 155                 160 


Asp Lys Ala Phe Glu Asp Trp Leu Asn Asp Asp Leu Gly Ser Tyr Gln 
                165                 170                 175     


Gly Ala Gln Gly Asn Arg Tyr Val Gly Phe Gly Asn Thr Pro Pro Pro 
            180                 185                 190         


Gln Lys Lys Glu Asp Asp Phe Leu Asn Asn Ala Met Ser Ser Leu Tyr 
        195                 200                 205             


Ser Gly Trp Ser Ser Phe Thr Thr Gly Ala Ser Arg Phe Ala Ser Ala 
    210                 215                 220                 


Ala Lys Glu Gly Ala Thr Lys Phe Gly Ser Gln Ala Ser Gln Lys Ala 
225                 230                 235                 240 


Ser Glu Leu Gly His Ser Leu Asn Glu Asn Val Leu Lys Pro Ala Gln 
                245                 250                 255     


Glu Lys Val Lys Glu Gly Lys Ile Phe Asp Asp Val Ser Ser Gly Val 
            260                 265                 270         


Ser Gln Leu Ala Ser Lys Cys Gln Arg Arg Leu Cys Cys His Gln Ser 
        275                 280                 285             


His Cys Ser Ala Gly His Leu Gly Arg Ala Phe Cys Pro Val Ser Trp 
    290                 295                 300                 


His Glu Ala Leu Cys Gly Gln Thr Gly Arg Glu Glu Gln Ala Ser Leu 
305                 310                 315                 320 


Leu Pro Pro Lys His Val Val Gly Ala Leu Glu Val Cys Ala Arg Gly 
                325                 330                 335     


Cys Pro Arg Cys His Val Pro His Thr Pro Gly Thr Ala Ala Glu Trp 
            340                 345                 350         


Pro Gly Arg Leu Cys Leu Ser Arg Glu Ser Val Val Arg Asp Gly Gly 
        355                 360                 365             


Thr Ser Pro Pro Phe Phe Arg Gly Lys Gln Arg Ala Pro Trp Thr Ala 
    370                 375                 380                 


Pro Arg Arg Ala Thr Val Ile Arg Thr Ala Val Trp Thr Thr Ser Lys 
385                 390                 395                 400 


Thr Ala Thr 
            


<210>  696
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFGAP2__Homo_sapiens__NP_001229761

<400>  696

Met Ala Ala Glu Pro Asn Lys Thr Glu Ile Gln Thr Leu Phe Lys Arg 
1               5                   10                  15      


Leu Arg Ala Val Pro Thr Asn Lys Ala Cys Phe Asp Cys Gly Ala Lys 
            20                  25                  30          


Asn Pro Ser Trp Ala Ser Ile Thr Tyr Gly Val Phe Leu Cys Ile Asp 
        35                  40                  45              


Cys Ser Gly Val His Arg Ser Leu Gly Val His Leu Ser Phe Ile Arg 
    50                  55                  60                  


Ser Thr Glu Leu Asp Ser Asn Trp Asn Trp Phe Gln Leu Arg Cys Met 
65                  70                  75                  80  


Gln Val Gly Gly Asn Ala Asn Ala Thr Ala Phe Phe Arg Gln His Gly 
                85                  90                  95      


Cys Thr Ala Asn Asp Ala Asn Thr Lys Tyr Asn Ser Arg Ala Ala Gln 
            100                 105                 110         


Met Tyr Arg Glu Lys Ile Arg Gln Leu Gly Ser Ala Ala Leu Ala Arg 
        115                 120                 125             


His Gly Thr Asp Pro Pro Ala Trp Asp Ala Pro Ala Thr Glu Pro Ser 
    130                 135                 140                 


Gly Thr Gln Gln Pro Ala Pro Ser Thr Glu Ser Ser Gly Leu Ala Gln 
145                 150                 155                 160 


Pro Glu His Gly Pro Asn Thr Asp Leu Leu Gly Thr Ser Pro Lys Ala 
                165                 170                 175     


Ser Leu Glu Leu Lys Ser Ser Ile Ile Gly Lys Lys Lys Pro Ala Ala 
            180                 185                 190         


Ala Lys Lys Gly Leu Gly Ala Lys Lys Gly Leu Gly Ala Gln Lys Val 
        195                 200                 205             


Ser Ser Gln Ser Phe Ser Glu Ile Glu Arg Gln Ala Gln Val Ala Glu 
    210                 215                 220                 


Lys Leu Arg Glu Gln Gln Ala Ala Asp Ala Lys Lys Gln Ala Glu Glu 
225                 230                 235                 240 


Ser Met Val Ala Ser Met Arg Leu Ala Tyr Gln Glu Leu Gln Ile Asp 
                245                 250                 255     


Arg Lys Lys Glu Glu Lys Lys Leu Gln Asn Leu Glu Gly Lys Lys Arg 
            260                 265                 270         


Glu Gln Ala Glu Arg Leu Gly Met Gly Leu Val Ser Arg Ser Ser Val 
        275                 280                 285             


Ser His Ser Val Leu Ser Glu Met Gln Val Ile Glu Gln Glu Thr Pro 
    290                 295                 300                 


Val Ser Ala Lys Ser Ser Arg Ser Gln Leu Asp Leu Phe Asp Asp Val 
305                 310                 315                 320 


Gly Thr Phe Ala Ser Gly Pro Pro Lys Tyr Lys Asp Asn Pro Phe Ser 
                325                 330                 335     


Leu Gly Glu Ser Phe Gly Ser Arg Trp Asp Thr Asp Ala Ala Trp Gly 
            340                 345                 350         


Met Asp Arg Val Glu Glu Lys Glu Pro Glu Val Thr Ile Ser Ser Ile 
        355                 360                 365             


Arg Pro Ile Ser Glu Arg Ala Thr Asn Arg Arg Glu Val Glu Ser Arg 
    370                 375                 380                 


Ser Ser Gly Leu Glu Ser Ser Glu Ala Arg Gln Lys Phe Ala Gly Ala 
385                 390                 395                 400 


Lys Ala Ile Ser Ser Asp Met Phe Phe Gly Arg Glu Val Asp Ala Glu 
                405                 410                 415     


Tyr Glu Ala Arg Ser Arg Leu Gln Gln Leu Ser Gly Ser Ser Ala Ile 
            420                 425                 430         


Ser Ser Ser Asp Leu Phe Gly Asp Met Asp Gly Ala His Gly Ala Gly 
        435                 440                 445             


Ser Val Ser Leu Gly Asn Val Leu Pro Thr Ala Asp Ile Ala Gln Phe 
    450                 455                 460                 


Lys Gln Gly Val Lys Ser Val Ala Gly Lys Met Ala Val Leu Ala Asn 
465                 470                 475                 480 


Gly Val Met Asn Ser Leu Gln Asp Arg Tyr Gly Ser Tyr 
                485                 490             


<210>  697
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFGAP3__Homo_sapiens__NP_001135765

<400>  697

Met Gly Asp Pro Ser Lys Gln Asp Ile Leu Thr Ile Phe Lys Arg Leu 
1               5                   10                  15      


Arg Ser Val Pro Thr Asn Lys Val Cys Phe Asp Cys Gly Ala Lys Asn 
            20                  25                  30          


Pro Ser Trp Ala Ser Ile Thr Tyr Gly Val Phe Leu Cys Ile Asp Cys 
        35                  40                  45              


Ser Gly Ser His Arg Ser Leu Gly Val His Leu Ser Phe Ile Arg Ser 
    50                  55                  60                  


Thr Glu Leu Asp Ser Asn Trp Ser Trp Phe Gln Leu Arg Cys Met Gln 
65                  70                  75                  80  


Val Gly Gly Asn Ala Ser Ala Leu Trp Leu Asp Ser Cys Val Val Pro 
                85                  90                  95      


Pro Leu Ser Pro Pro Pro Lys Glu Glu Asp Phe Phe Ala Ser His Val 
            100                 105                 110         


Ser Pro Glu Val Ser Asp Thr Ala Trp Ala Ser Ala Ile Ala Glu Pro 
        115                 120                 125             


Ser Ser Leu Thr Ser Arg Pro Val Glu Thr Thr Leu Glu Asn Asn Glu 
    130                 135                 140                 


Gly Gly Gln Glu Gln Gly Pro Ser Val Glu Gly Leu Asn Val Pro Thr 
145                 150                 155                 160 


Lys Ala Thr Leu Glu Val Ser Ser Ile Ile Lys Lys Lys Pro Asn Gln 
                165                 170                 175     


Ala Lys Lys Gly Leu Gly Ala Lys Lys Gly Ser Leu Gly Ala Gln Lys 
            180                 185                 190         


Leu Ala Asn Thr Cys Phe Asn Glu Ile Glu Lys Gln Ala Gln Ala Ala 
        195                 200                 205             


Asp Lys Met Lys Glu Gln Glu Asp Leu Ala Lys Val Val Ser Lys Glu 
    210                 215                 220                 


Glu Ser Ile Val Ser Ser Leu Arg Leu Ala Tyr Lys Asp Leu Glu Ile 
225                 230                 235                 240 


Gln Met Lys Lys Asp Glu Lys Met Asn Ile Ser Gly Lys Lys Asn Val 
                245                 250                 255     


Asp Ser Asp Arg Leu Gly Met Gly Phe Gly Asn Cys Arg Ser Val Ile 
            260                 265                 270         


Ser His Ser Val Thr Ser Asp Met Gln Thr Ile Glu Gln Glu Ser Pro 
        275                 280                 285             


Ile Met Ala Lys Pro Arg Lys Lys Tyr Asn Asp Asp Ser Asp Asp Ser 
    290                 295                 300                 


Tyr Phe Thr Ser Ser Ser Ser Tyr Phe Asp Glu Pro Val Glu Leu Arg 
305                 310                 315                 320 


Ser Ser Ser Phe Ser Ser Trp Asp Asp Ser Ser Asp Ser Tyr Trp Lys 
                325                 330                 335     


Lys Glu Thr Ser Lys Asp Thr Glu Thr Val Leu Lys Thr Thr Gly Tyr 
            340                 345                 350         


Ser Asp Arg Pro Thr Ala Arg Arg Lys Pro Asp Tyr Glu Pro Val Glu 
        355                 360                 365             


Asn Thr Asp Glu Ala Gln Lys Lys Phe Gly Asn Val Lys Ala Ile Ser 
    370                 375                 380                 


Ser Asp Met Tyr Phe Gly Arg Gln Ser Gln Ala Asp Tyr Glu Thr Arg 
385                 390                 395                 400 


Ala Arg Leu Glu Arg Leu Ser Ala Ser Ser Ser Ile Ser Ser Ala Asp 
                405                 410                 415     


Leu Phe Glu Glu Pro Arg Lys Gln Pro Ala Gly Asn Tyr Ser Leu Ser 
            420                 425                 430         


Ser Val Leu Pro Asn Ala Pro Asp Met Ala Gln Phe Lys Gln Gly Val 
        435                 440                 445             


Arg Ser Val Ala Gly Lys Leu Ser Val Phe Ala Asn Gly Val Val Thr 
    450                 455                 460                 


Ser Ile Gln Asp Arg Tyr Gly Ser 
465                 470         


<210>  698
<211>  1849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFGEF1__Homo_sapiens__NP_006412

<400>  698

Met Tyr Glu Gly Lys Lys Thr Lys Asn Met Phe Leu Thr Arg Ala Leu 
1               5                   10                  15      


Glu Lys Ile Leu Ala Asp Lys Glu Val Lys Lys Ala His His Ser Gln 
            20                  25                  30          


Leu Arg Lys Ala Cys Glu Val Ala Leu Glu Glu Ile Lys Ala Glu Thr 
        35                  40                  45              


Glu Lys Gln Ser Pro Pro His Gly Glu Ala Lys Ala Gly Ser Ser Thr 
    50                  55                  60                  


Leu Pro Pro Val Lys Ser Lys Thr Asn Phe Ile Glu Ala Asp Lys Tyr 
65                  70                  75                  80  


Phe Leu Pro Phe Glu Leu Ala Cys Gln Ser Lys Cys Pro Arg Ile Val 
                85                  90                  95      


Ser Thr Ser Leu Asp Cys Leu Gln Lys Leu Ile Ala Tyr Gly His Leu 
            100                 105                 110         


Thr Gly Asn Ala Pro Asp Ser Thr Thr Pro Gly Lys Lys Leu Ile Asp 
        115                 120                 125             


Arg Ile Ile Glu Thr Ile Cys Gly Cys Phe Gln Gly Pro Gln Thr Asp 
    130                 135                 140                 


Glu Gly Val Gln Leu Gln Ile Ile Lys Ala Leu Leu Thr Ala Val Thr 
145                 150                 155                 160 


Ser Gln His Ile Glu Ile His Glu Gly Thr Val Leu Gln Ala Val Arg 
                165                 170                 175     


Thr Cys Tyr Asn Ile Tyr Leu Ala Ser Lys Asn Leu Ile Asn Gln Thr 
            180                 185                 190         


Thr Ala Lys Ala Thr Leu Thr Gln Met Leu Asn Val Ile Phe Ala Arg 
        195                 200                 205             


Met Glu Asn Gln Ala Leu Gln Glu Ala Lys Gln Met Glu Lys Glu Arg 
    210                 215                 220                 


His Arg Gln His His His Leu Leu Gln Ser Pro Val Ser His His Glu 
225                 230                 235                 240 


Pro Glu Ser Pro Gln Leu Arg Tyr Leu Pro Pro Gln Thr Val Asp His 
                245                 250                 255     


Ile Ser Gln Glu His Glu Gly Asp Leu Asp Leu His Thr Asn Asp Val 
            260                 265                 270         


Asp Lys Ser Leu Gln Asp Asp Thr Glu Pro Glu Asn Gly Ser Asp Ile 
        275                 280                 285             


Ser Ser Ala Glu Asn Glu Gln Thr Glu Ala Asp Gln Ala Thr Ala Ala 
    290                 295                 300                 


Glu Thr Leu Ser Lys Asn Glu Val Leu Tyr Asp Gly Glu Asn His Asp 
305                 310                 315                 320 


Cys Glu Glu Lys Pro Gln Asp Ile Val Gln Asn Ile Val Glu Glu Met 
                325                 330                 335     


Val Asn Ile Val Val Gly Asp Met Gly Glu Gly Thr Thr Ile Asn Ala 
            340                 345                 350         


Ser Ala Asp Gly Asn Ile Gly Thr Ile Glu Asp Gly Ser Asp Ser Glu 
        355                 360                 365             


Asn Ile Gln Ala Asn Gly Ile Pro Gly Thr Pro Ile Ser Val Ala Tyr 
    370                 375                 380                 


Thr Pro Ser Leu Pro Asp Asp Arg Leu Ser Val Ser Ser Asn Asp Thr 
385                 390                 395                 400 


Gln Glu Ser Gly Asn Ser Ser Gly Pro Ser Pro Gly Ala Lys Phe Ser 
                405                 410                 415     


His Ile Leu Gln Lys Asp Ala Phe Leu Val Phe Arg Ser Leu Cys Lys 
            420                 425                 430         


Leu Ser Met Lys Pro Leu Ser Asp Gly Pro Pro Asp Pro Lys Ser His 
        435                 440                 445             


Glu Leu Arg Ser Lys Ile Leu Ser Leu Gln Leu Leu Leu Ser Ile Leu 
    450                 455                 460                 


Gln Asn Ala Gly Pro Ile Phe Arg Thr Asn Glu Met Phe Ile Asn Ala 
465                 470                 475                 480 


Ile Lys Gln Tyr Leu Cys Val Ala Leu Ser Lys Asn Gly Val Ser Ser 
                485                 490                 495     


Val Pro Glu Val Phe Glu Leu Ser Leu Ser Ile Phe Leu Thr Leu Leu 
            500                 505                 510         


Ser Asn Phe Lys Thr His Leu Lys Met Gln Ile Glu Val Phe Phe Lys 
        515                 520                 525             


Glu Ile Phe Leu Tyr Ile Leu Glu Thr Ser Thr Ser Ser Phe Asp His 
    530                 535                 540                 


Lys Trp Met Val Ile Gln Thr Leu Thr Arg Ile Cys Ala Asp Ala Gln 
545                 550                 555                 560 


Ser Val Val Asp Ile Tyr Val Asn Tyr Asp Cys Asp Leu Asn Ala Ala 
                565                 570                 575     


Asn Ile Phe Glu Arg Leu Val Asn Asp Leu Ser Lys Ile Ala Gln Gly 
            580                 585                 590         


Arg Gly Ser Gln Glu Leu Gly Met Ser Asn Val Gln Glu Leu Ser Leu 
        595                 600                 605             


Arg Lys Lys Gly Leu Glu Cys Leu Val Ser Ile Leu Lys Cys Met Val 
    610                 615                 620                 


Glu Trp Ser Lys Asp Gln Tyr Val Asn Pro Asn Ser Gln Thr Thr Leu 
625                 630                 635                 640 


Gly Gln Glu Lys Pro Ser Glu Gln Glu Met Ser Glu Ile Lys His Pro 
                645                 650                 655     


Glu Thr Ile Asn Arg Tyr Gly Ser Leu Asn Ser Leu Glu Ser Thr Ser 
            660                 665                 670         


Ser Ser Gly Ile Gly Ser Tyr Ser Thr Gln Met Ser Gly Thr Asp Asn 
        675                 680                 685             


Pro Glu Gln Phe Glu Val Leu Lys Gln Gln Lys Glu Ile Ile Glu Gln 
    690                 695                 700                 


Gly Ile Asp Leu Phe Asn Lys Lys Pro Lys Arg Gly Ile Gln Tyr Leu 
705                 710                 715                 720 


Gln Glu Gln Gly Met Leu Gly Thr Thr Pro Glu Asp Ile Ala Gln Phe 
                725                 730                 735     


Leu His Gln Glu Glu Arg Leu Asp Ser Thr Gln Val Gly Glu Phe Leu 
            740                 745                 750         


Gly Asp Asn Asp Lys Phe Asn Lys Glu Val Met Tyr Ala Tyr Val Asp 
        755                 760                 765             


Gln His Asp Phe Ser Gly Lys Asp Phe Val Ser Ala Leu Arg Met Phe 
    770                 775                 780                 


Leu Glu Gly Phe Arg Leu Pro Gly Glu Ala Gln Lys Ile Asp Arg Leu 
785                 790                 795                 800 


Met Glu Lys Phe Ala Ala Arg Tyr Leu Glu Cys Asn Gln Gly Gln Thr 
                805                 810                 815     


Leu Phe Ala Ser Ala Asp Thr Ala Tyr Val Leu Ala Tyr Ser Ile Ile 
            820                 825                 830         


Met Leu Thr Thr Asp Leu His Ser Pro Gln Val Lys Asn Lys Met Thr 
        835                 840                 845             


Lys Glu Gln Tyr Ile Lys Met Asn Arg Gly Ile Asn Asp Ser Lys Asp 
    850                 855                 860                 


Leu Pro Glu Glu Tyr Leu Ser Ala Ile Tyr Asn Glu Ile Ala Gly Lys 
865                 870                 875                 880 


Lys Ile Ser Met Lys Glu Thr Lys Glu Leu Thr Ile Pro Thr Lys Ser 
                885                 890                 895     


Ser Lys Gln Asn Val Ala Ser Glu Lys Gln Arg Arg Leu Leu Tyr Asn 
            900                 905                 910         


Leu Glu Met Glu Gln Met Ala Lys Thr Ala Lys Ala Leu Met Glu Ala 
        915                 920                 925             


Val Ser His Val Gln Ala Pro Phe Thr Ser Ala Thr His Leu Glu His 
    930                 935                 940                 


Val Arg Pro Met Phe Lys Leu Ala Trp Thr Pro Phe Leu Ala Ala Phe 
945                 950                 955                 960 


Ser Val Gly Leu Gln Asp Cys Asp Asp Thr Glu Val Ala Ser Leu Cys 
                965                 970                 975     


Leu Glu Gly Ile Arg Cys Ala Ile Arg Ile Ala Cys Ile Phe Ser Ile 
            980                 985                 990         


Gln Leu Glu Arg Asp Ala Tyr Val  Gln Ala Leu Ala Arg  Phe Thr Leu 
        995                 1000                 1005             


Leu Thr  Val Ser Ser Gly Ile  Thr Glu Met Lys Gln  Lys Asn Ile 
    1010                 1015                 1020             


Asp Thr  Ile Lys Thr Leu Ile  Thr Val Ala His Thr  Asp Gly Asn 
    1025                 1030                 1035             


Tyr Leu  Gly Asn Ser Trp His  Glu Ile Leu Lys Cys  Ile Ser Gln 
    1040                 1045                 1050             


Leu Glu  Leu Ala Gln Leu Ile  Gly Thr Gly Val Lys  Pro Arg Tyr 
    1055                 1060                 1065             


Ile Ser  Gly Thr Val Arg Gly  Arg Glu Gly Ser Leu  Thr Gly Thr 
    1070                 1075                 1080             


Lys Asp  Gln Ala Pro Asp Glu  Phe Val Gly Leu Gly  Leu Val Gly 
    1085                 1090                 1095             


Gly Asn  Val Asp Trp Lys Gln  Ile Ala Ser Ile Gln  Glu Ser Ile 
    1100                 1105                 1110             


Gly Glu  Thr Ser Ser Gln Ser  Val Val Val Ala Val  Asp Arg Ile 
    1115                 1120                 1125             


Phe Thr  Gly Ser Thr Arg Leu  Asp Gly Asn Ala Ile  Val Asp Phe 
    1130                 1135                 1140             


Val Arg  Trp Leu Cys Ala Val  Ser Met Asp Glu Leu  Leu Ser Thr 
    1145                 1150                 1155             


Thr His  Pro Arg Met Phe Ser  Leu Gln Lys Ile Val  Glu Ile Ser 
    1160                 1165                 1170             


Tyr Tyr  Asn Met Gly Arg Ile  Arg Leu Gln Trp Ser  Arg Ile Trp 
    1175                 1180                 1185             


Glu Val  Ile Gly Asp His Phe  Asn Lys Val Gly Cys  Asn Pro Asn 
    1190                 1195                 1200             


Glu Asp  Val Ala Ile Phe Ala  Val Asp Ser Leu Arg  Gln Leu Ser 
    1205                 1210                 1215             


Met Lys  Phe Leu Glu Lys Gly  Glu Leu Ala Asn Phe  Arg Phe Gln 
    1220                 1225                 1230             


Lys Asp  Phe Leu Arg Pro Phe  Glu His Ile Met Lys  Arg Asn Arg 
    1235                 1240                 1245             


Ser Pro  Thr Ile Arg Asp Met  Val Val Arg Cys Ile  Ala Gln Met 
    1250                 1255                 1260             


Val Asn  Ser Gln Ala Ala Asn  Ile Arg Ser Gly Trp  Lys Asn Ile 
    1265                 1270                 1275             


Phe Ser  Val Phe His Leu Ala  Ala Ser Asp Gln Asp  Glu Ser Ile 
    1280                 1285                 1290             


Val Glu  Leu Ala Phe Gln Thr  Thr Gly His Ile Val  Thr Leu Val 
    1295                 1300                 1305             


Phe Glu  Lys His Phe Pro Ala  Thr Ile Asp Ser Phe  Gln Asp Ala 
    1310                 1315                 1320             


Val Lys  Cys Leu Ser Glu Phe  Ala Cys Asn Ala Ala  Phe Pro Asp 
    1325                 1330                 1335             


Thr Ser  Met Glu Ala Ile Arg  Leu Ile Arg His Cys  Ala Lys Tyr 
    1340                 1345                 1350             


Val Ser  Asp Arg Pro Gln Ala  Phe Lys Glu Tyr Thr  Ser Asp Asp 
    1355                 1360                 1365             


Met Asn  Val Ala Pro Glu Asp  Arg Val Trp Val Arg  Gly Trp Phe 
    1370                 1375                 1380             


Pro Ile  Leu Phe Glu Leu Ser  Cys Ile Ile Asn Arg  Cys Lys Leu 
    1385                 1390                 1395             


Asp Val  Arg Thr Arg Gly Leu  Thr Val Met Phe Glu  Ile Met Lys 
    1400                 1405                 1410             


Thr Tyr  Gly His Thr Tyr Glu  Lys His Trp Trp Gln  Asp Leu Phe 
    1415                 1420                 1425             


Arg Ile  Val Phe Arg Ile Phe  Asp Asn Met Lys Leu  Pro Glu Gln 
    1430                 1435                 1440             


Gln Thr  Glu Lys Ala Glu Trp  Met Thr Thr Thr Cys  Asn His Ala 
    1445                 1450                 1455             


Leu Tyr  Ala Ile Cys Asp Val  Phe Thr Gln Tyr Leu  Glu Val Leu 
    1460                 1465                 1470             


Ser Asp  Val Leu Leu Asp Asp  Ile Phe Ala Gln Leu  Tyr Trp Cys 
    1475                 1480                 1485             


Val Gln  Gln Asp Asn Glu Gln  Leu Ala Arg Ser Gly  Thr Asn Cys 
    1490                 1495                 1500             


Leu Glu  Asn Val Val Ile Leu  Asn Gly Glu Lys Phe  Thr Leu Glu 
    1505                 1510                 1515             


Ile Trp  Asp Lys Thr Cys Asn  Cys Thr Leu Asp Ile  Phe Lys Thr 
    1520                 1525                 1530             


Thr Ile  Pro His Ala Leu Leu  Thr Trp Arg Pro Asn  Ser Gly Glu 
    1535                 1540                 1545             


Thr Ala  Pro Pro Pro Pro Ser  Pro Val Ser Glu Lys  Pro Leu Asp 
    1550                 1555                 1560             


Thr Ile  Ser Gln Lys Ser Val  Asp Ile His Asp Ser  Ile Gln Pro 
    1565                 1570                 1575             


Arg Ser  Val Asp Asn Arg Pro  Gln Ala Pro Leu Val  Ser Ala Ser 
    1580                 1585                 1590             


Ala Val  Asn Glu Glu Val Ser  Lys Ile Lys Ser Thr  Ala Lys Phe 
    1595                 1600                 1605             


Pro Glu  Gln Lys Leu Phe Ala  Ala Leu Leu Ile Lys  Cys Val Val 
    1610                 1615                 1620             


Gln Leu  Glu Leu Ile Gln Thr  Ile Asp Asn Ile Val  Phe Phe Pro 
    1625                 1630                 1635             


Ala Thr  Ser Lys Lys Glu Asp  Ala Glu Asn Leu Ala  Ala Ala Gln 
    1640                 1645                 1650             


Arg Asp  Ala Val Asp Phe Asp  Val Arg Val Asp Thr  Gln Asp Gln 
    1655                 1660                 1665             


Gly Met  Tyr Arg Phe Leu Thr  Ser Gln Gln Leu Phe  Lys Leu Leu 
    1670                 1675                 1680             


Asp Cys  Leu Leu Glu Ser His  Arg Phe Ala Lys Ala  Phe Asn Ser 
    1685                 1690                 1695             


Asn Asn  Glu Gln Arg Thr Ala  Leu Trp Lys Ala Gly  Phe Lys Gly 
    1700                 1705                 1710             


Lys Ser  Lys Pro Asn Leu Leu  Lys Gln Glu Thr Ser  Ser Leu Ala 
    1715                 1720                 1725             


Cys Gly  Leu Arg Ile Leu Phe  Arg Met Tyr Met Asp  Glu Ser Arg 
    1730                 1735                 1740             


Val Ser  Ala Trp Glu Glu Val  Gln Gln Arg Leu Leu  Asn Val Cys 
    1745                 1750                 1755             


Ser Glu  Ala Leu Ser Tyr Phe  Leu Thr Leu Thr Ser  Glu Ser His 
    1760                 1765                 1770             


Arg Glu  Ala Trp Thr Asn Leu  Leu Leu Leu Phe Leu  Thr Lys Val 
    1775                 1780                 1785             


Leu Lys  Ile Ser Asp Asn Arg  Phe Lys Ala His Ala  Ser Phe Tyr 
    1790                 1795                 1800             


Tyr Pro  Leu Leu Cys Glu Ile  Met Gln Phe Asp Leu  Ile Pro Glu 
    1805                 1810                 1815             


Leu Arg  Ala Val Leu Arg Arg  Phe Phe Leu Arg Ile  Gly Val Val 
    1820                 1825                 1830             


Phe Gln  Ile Ser Gln Pro Pro  Glu Gln Glu Leu Gly  Ile Asn Lys 
    1835                 1840                 1845             


Gln 
    


<210>  699
<211>  1785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFGEF2__Homo_sapiens__NP_006411

<400>  699

Met Gln Glu Ser Gln Thr Lys Ser Met Phe Val Ser Arg Ala Leu Glu 
1               5                   10                  15      


Lys Ile Leu Ala Asp Lys Glu Val Lys Arg Pro Gln His Ser Gln Leu 
            20                  25                  30          


Arg Arg Ala Cys Gln Val Ala Leu Asp Glu Ile Lys Ala Glu Ile Glu 
        35                  40                  45              


Lys Gln Arg Leu Gly Thr Ala Ala Pro Pro Lys Ala Asn Phe Ile Glu 
    50                  55                  60                  


Ala Asp Lys Tyr Phe Leu Pro Phe Glu Leu Ala Cys Gln Ser Lys Ser 
65                  70                  75                  80  


Pro Arg Val Val Ser Thr Ser Leu Asp Cys Leu Gln Lys Leu Ile Ala 
                85                  90                  95      


Tyr Gly His Ile Thr Gly Asn Ala Pro Asp Ser Gly Ala Pro Gly Lys 
            100                 105                 110         


Arg Leu Ile Asp Arg Ile Val Glu Thr Ile Cys Ser Cys Phe Gln Gly 
        115                 120                 125             


Pro Gln Thr Asp Glu Gly Val Gln Leu Gln Ile Ile Lys Ala Leu Leu 
    130                 135                 140                 


Thr Ala Val Thr Ser Pro His Ile Glu Ile His Glu Gly Thr Ile Leu 
145                 150                 155                 160 


Gln Thr Val Arg Thr Cys Tyr Asn Ile Tyr Leu Ala Ser Lys Asn Leu 
                165                 170                 175     


Ile Asn Gln Thr Thr Ala Lys Ala Thr Leu Thr Gln Met Leu Asn Val 
            180                 185                 190         


Ile Phe Thr Arg Met Glu Asn Gln Val Leu Gln Glu Ala Arg Glu Leu 
        195                 200                 205             


Glu Lys Pro Ile Gln Ser Lys Pro Gln Ser Pro Val Ile Gln Ala Ala 
    210                 215                 220                 


Ala Val Ser Pro Lys Phe Val Arg Leu Lys His Ser Gln Ala Gln Ser 
225                 230                 235                 240 


Lys Pro Thr Thr Pro Glu Lys Thr Asp Leu Thr Asn Gly Glu His Ala 
                245                 250                 255     


Arg Ser Asp Ser Gly Lys Val Ser Thr Glu Asn Gly Asp Ala Pro Arg 
            260                 265                 270         


Glu Arg Gly Ser Ser Leu Ser Gly Thr Asp Asp Gly Ala Gln Glu Val 
        275                 280                 285             


Val Lys Asp Ile Leu Glu Asp Val Val Thr Ser Ala Ile Lys Glu Ala 
    290                 295                 300                 


Ala Glu Lys His Gly Leu Thr Glu Pro Glu Arg Val Leu Gly Glu Leu 
305                 310                 315                 320 


Glu Cys Gln Glu Cys Ala Ile Pro Pro Gly Val Asp Glu Asn Ser Gln 
                325                 330                 335     


Thr Asn Gly Ile Ala Asp Asp Arg Gln Ser Leu Ser Ser Ala Asp Asn 
            340                 345                 350         


Leu Glu Ser Asp Ala Gln Gly His Gln Val Ala Ala Arg Phe Ser His 
        355                 360                 365             


Val Leu Gln Lys Asp Ala Phe Leu Val Phe Arg Ser Leu Cys Lys Leu 
    370                 375                 380                 


Ser Met Lys Pro Leu Gly Glu Gly Pro Pro Asp Pro Lys Ser His Glu 
385                 390                 395                 400 


Leu Arg Ser Lys Val Val Ser Leu Gln Leu Leu Leu Ser Val Leu Gln 
                405                 410                 415     


Asn Ala Gly Pro Val Phe Arg Thr His Glu Met Phe Ile Asn Ala Ile 
            420                 425                 430         


Lys Gln Tyr Leu Cys Val Ala Leu Ser Lys Asn Gly Val Ser Ser Val 
        435                 440                 445             


Pro Asp Val Phe Glu Leu Ser Leu Ala Ile Phe Leu Thr Leu Leu Ser 
    450                 455                 460                 


Asn Phe Lys Met His Leu Lys Met Gln Ile Glu Val Phe Phe Lys Glu 
465                 470                 475                 480 


Ile Phe Leu Asn Ile Leu Glu Thr Ser Thr Ser Ser Phe Glu His Arg 
                485                 490                 495     


Trp Met Val Ile Gln Thr Leu Thr Arg Ile Cys Ala Asp Ala Gln Cys 
            500                 505                 510         


Val Val Asp Ile Tyr Val Asn Tyr Asp Cys Asp Leu Asn Ala Ala Asn 
        515                 520                 525             


Ile Phe Glu Arg Leu Val Asn Asp Leu Ser Lys Ile Ala Gln Gly Arg 
    530                 535                 540                 


Ser Gly His Glu Leu Gly Met Thr Pro Leu Gln Glu Leu Ser Leu Arg 
545                 550                 555                 560 


Lys Lys Gly Leu Glu Cys Leu Val Ser Ile Leu Lys Cys Met Val Glu 
                565                 570                 575     


Trp Ser Lys Asp Leu Tyr Val Asn Pro Asn His Gln Thr Ser Leu Gly 
            580                 585                 590         


Gln Glu Arg Leu Thr Asp Gln Glu Ile Gly Asp Gly Lys Gly Leu Asp 
        595                 600                 605             


Met Ala Arg Arg Cys Ser Val Thr Ser Met Glu Ser Thr Val Ser Ser 
    610                 615                 620                 


Gly Thr Gln Thr Thr Val Gln Asp Asp Pro Glu Gln Phe Glu Val Ile 
625                 630                 635                 640 


Lys Gln Gln Lys Glu Ile Ile Glu His Gly Ile Glu Leu Phe Asn Lys 
                645                 650                 655     


Lys Pro Lys Arg Gly Ile Gln Phe Leu Gln Glu Gln Gly Met Leu Gly 
            660                 665                 670         


Thr Ser Val Glu Asp Ile Ala Gln Phe Leu His Gln Glu Glu Arg Leu 
        675                 680                 685             


Asp Ser Thr Gln Val Gly Asp Phe Leu Gly Asp Ser Ala Arg Phe Asn 
    690                 695                 700                 


Lys Glu Val Met Tyr Ala Tyr Val Asp Gln Leu Asp Phe Cys Glu Lys 
705                 710                 715                 720 


Glu Phe Val Ser Ala Leu Arg Thr Phe Leu Glu Gly Phe Arg Leu Pro 
                725                 730                 735     


Gly Glu Ala Gln Lys Ile Asp Arg Leu Met Glu Lys Phe Ala Ala Arg 
            740                 745                 750         


Tyr Ile Glu Cys Asn Gln Gly Gln Thr Leu Phe Ala Ser Ala Asp Thr 
        755                 760                 765             


Ala Tyr Val Leu Ala Tyr Ser Ile Ile Met Leu Thr Thr Asp Leu His 
    770                 775                 780                 


Ser Pro Gln Val Lys Asn Lys Met Thr Lys Glu Gln Tyr Ile Lys Met 
785                 790                 795                 800 


Asn Arg Gly Ile Asn Asp Ser Lys Asp Leu Pro Glu Glu Tyr Leu Ser 
                805                 810                 815     


Ser Ile Tyr Glu Glu Ile Glu Gly Lys Lys Ile Ala Met Lys Glu Thr 
            820                 825                 830         


Lys Glu Leu Thr Ile Ala Thr Lys Ser Thr Lys Gln Asn Val Ala Ser 
        835                 840                 845             


Glu Lys Gln Arg Arg Leu Leu Tyr Asn Leu Glu Met Glu Gln Met Ala 
    850                 855                 860                 


Lys Thr Ala Lys Ala Leu Met Glu Ala Val Ser His Ala Lys Ala Pro 
865                 870                 875                 880 


Phe Thr Ser Ala Thr His Leu Asp His Val Arg Pro Met Phe Lys Leu 
                885                 890                 895     


Val Trp Thr Pro Leu Leu Ala Ala Tyr Ser Ile Gly Leu Gln Asn Cys 
            900                 905                 910         


Asp Asp Thr Glu Val Ala Ser Leu Cys Leu Glu Gly Ile Arg Cys Ala 
        915                 920                 925             


Ile Arg Ile Ala Cys Ile Phe Gly Met Gln Leu Glu Arg Asp Ala Tyr 
    930                 935                 940                 


Val Gln Ala Leu Ala Arg Phe Ser Leu Leu Thr Ala Ser Ser Ser Ile 
945                 950                 955                 960 


Thr Glu Met Lys Gln Lys Asn Ile Asp Thr Ile Lys Thr Leu Ile Thr 
                965                 970                 975     


Val Ala His Thr Asp Gly Asn Tyr Leu Gly Asn Ser Trp His Glu Ile 
            980                 985                 990         


Leu Lys Cys Ile Ser Gln Leu Glu  Leu Ala Gln Leu Ile  Gly Thr Gly 
        995                 1000                 1005             


Val Lys  Thr Arg Tyr Leu Ser  Gly Ser Gly Arg Glu  Arg Glu Gly 
    1010                 1015                 1020             


Ser Leu  Lys Gly His Thr Leu  Ala Gly Glu Glu Phe  Met Gly Leu 
    1025                 1030                 1035             


Gly Leu  Gly Asn Leu Val Ser  Gly Gly Val Asp Lys  Arg Gln Met 
    1040                 1045                 1050             


Ala Ser  Phe Gln Glu Ser Val  Gly Glu Thr Ser Ser  Gln Ser Val 
    1055                 1060                 1065             


Val Val  Ala Val Asp Arg Ile  Phe Thr Gly Ser Thr  Arg Leu Asp 
    1070                 1075                 1080             


Gly Asn  Ala Ile Val Asp Phe  Val Arg Trp Leu Cys  Ala Val Ser 
    1085                 1090                 1095             


Met Asp  Glu Leu Ala Ser Pro  His His Pro Arg Met  Phe Ser Leu 
    1100                 1105                 1110             


Gln Lys  Ile Val Glu Ile Ser  Tyr Tyr Asn Met Asn  Arg Ile Arg 
    1115                 1120                 1125             


Leu Gln  Trp Ser Arg Ile Trp  His Val Ile Gly Asp  His Phe Asn 
    1130                 1135                 1140             


Lys Val  Gly Cys Asn Pro Asn  Glu Asp Val Ala Ile  Phe Ala Val 
    1145                 1150                 1155             


Asp Ser  Leu Arg Gln Leu Ser  Met Lys Phe Leu Glu  Lys Gly Glu 
    1160                 1165                 1170             


Leu Ala  Asn Phe Arg Phe Gln  Lys Asp Phe Leu Arg  Pro Phe Glu 
    1175                 1180                 1185             


His Ile  Met Lys Lys Asn Arg  Ser Pro Thr Ile Arg  Asp Met Ala 
    1190                 1195                 1200             


Ile Arg  Cys Ile Ala Gln Met  Val Asn Ser Gln Ala  Ala Asn Ile 
    1205                 1210                 1215             


Arg Ser  Gly Trp Lys Asn Ile  Phe Ala Val Phe His  Gln Ala Ala 
    1220                 1225                 1230             


Ser Asp  His Asp Gly Asn Ile  Val Glu Leu Ala Phe  Gln Thr Thr 
    1235                 1240                 1245             


Cys His  Ile Val Thr Thr Ile  Phe Gln His His Phe  Pro Ala Ala 
    1250                 1255                 1260             


Ile Asp  Ser Phe Gln Asp Ala  Val Lys Cys Leu Ser  Glu Phe Ala 
    1265                 1270                 1275             


Cys Asn  Ala Ala Phe Pro Asp  Thr Ser Met Glu Ala  Ile Arg Leu 
    1280                 1285                 1290             


Ile Arg  Phe Cys Gly Lys Tyr  Val Ser Glu Arg Pro  Arg Val Leu 
    1295                 1300                 1305             


Gln Glu  Tyr Thr Ser Asp Asp  Met Asn Val Ala Pro  Gly Asp Arg 
    1310                 1315                 1320             


Val Trp  Val Arg Gly Trp Phe  Pro Ile Leu Phe Glu  Leu Ser Cys 
    1325                 1330                 1335             


Ile Ile  Asn Arg Cys Lys Leu  Asp Val Arg Thr Arg  Gly Leu Thr 
    1340                 1345                 1350             


Val Met  Phe Glu Ile Met Lys  Ser Tyr Gly His Thr  Phe Glu Lys 
    1355                 1360                 1365             


His Trp  Trp Gln Asp Leu Phe  Arg Ile Val Phe Arg  Ile Phe Asp 
    1370                 1375                 1380             


Asn Met  Lys Leu Pro Glu Gln  Leu Ser Glu Lys Ser  Glu Trp Met 
    1385                 1390                 1395             


Thr Thr  Thr Cys Asn His Ala  Leu Tyr Ala Ile Cys  Asp Val Phe 
    1400                 1405                 1410             


Thr Gln  Phe Tyr Glu Ala Leu  Asn Glu Val Leu Leu  Ser Asp Val 
    1415                 1420                 1425             


Phe Ala  Gln Leu Gln Trp Cys  Val Lys Gln Asp Asn  Glu Gln Leu 
    1430                 1435                 1440             


Ala Arg  Ser Gly Thr Asn Cys  Leu Glu Asn Leu Val  Ile Ser Asn 
    1445                 1450                 1455             


Gly Glu  Lys Phe Ser Pro Glu  Val Trp Asp Glu Thr  Cys Asn Cys 
    1460                 1465                 1470             


Met Leu  Asp Ile Phe Lys Thr  Thr Ile Pro His Val  Leu Leu Thr 
    1475                 1480                 1485             


Trp Arg  Pro Val Gly Met Glu  Glu Asp Ser Ser Glu  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Asp Leu Asp Arg Gln  Ser Leu Ser Ser Ile  Asp Lys Asn 
    1505                 1510                 1515             


Pro Ser  Glu Arg Gly Gln Ser  Gln Leu Ser Asn Pro  Thr Asp Asp 
    1520                 1525                 1530             


Ser Trp  Lys Gly Arg Pro Tyr  Ala Asn Gln Lys Leu  Phe Ala Ser 
    1535                 1540                 1545             


Leu Leu  Ile Lys Cys Val Val  Gln Leu Glu Leu Ile  Gln Thr Ile 
    1550                 1555                 1560             


Asp Asn  Ile Val Phe Tyr Pro  Ala Thr Ser Lys Lys  Glu Asp Ala 
    1565                 1570                 1575             


Glu His  Met Val Ala Ala Gln  Gln Asp Thr Leu Asp  Ala Asp Ile 
    1580                 1585                 1590             


His Ile  Glu Thr Glu Asp Gln  Gly Met Tyr Lys Tyr  Met Ser Ser 
    1595                 1600                 1605             


Gln His  Leu Phe Lys Leu Leu  Asp Cys Leu Gln Glu  Ser His Ser 
    1610                 1615                 1620             


Phe Ser  Lys Ala Phe Asn Ser  Asn Tyr Glu Gln Arg  Thr Val Leu 
    1625                 1630                 1635             


Trp Arg  Ala Gly Phe Lys Gly  Lys Ser Lys Pro Asn  Leu Leu Lys 
    1640                 1645                 1650             


Gln Glu  Thr Ser Ser Leu Ala  Cys Cys Leu Arg Ile  Leu Phe Arg 
    1655                 1660                 1665             


Met Tyr  Val Asp Glu Asn Arg  Arg Asp Ser Trp Glu  Glu Ile Gln 
    1670                 1675                 1680             


Gln Arg  Leu Leu Thr Val Cys  Ser Glu Ala Leu Ala  Tyr Phe Ile 
    1685                 1690                 1695             


Thr Val  Asn Ser Glu Ser His  Arg Glu Ala Trp Thr  Ser Leu Leu 
    1700                 1705                 1710             


Leu Leu  Leu Leu Thr Lys Thr  Leu Lys Ile Asn Asp  Glu Lys Phe 
    1715                 1720                 1725             


Lys Ala  His Ala Ser Met Tyr  Tyr Pro Tyr Leu Cys  Glu Ile Met 
    1730                 1735                 1740             


Gln Phe  Asp Leu Ile Pro Glu  Leu Arg Ala Val Leu  Arg Lys Phe 
    1745                 1750                 1755             


Phe Leu  Arg Ile Gly Val Val  Tyr Lys Ile Trp Ile  Pro Glu Glu 
    1760                 1765                 1770             


Pro Ser  Gln Val Pro Ala Ala  Leu Ser Pro Val Trp  
    1775                 1780                 1785 


<210>  700
<211>  2177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFGEF3__Homo_sapiens__NP_065073

<400>  700

Met Glu Glu Ile Leu Arg Lys Leu Gln Lys Glu Ala Ser Gly Ser Lys 
1               5                   10                  15      


Tyr Lys Ala Ile Lys Glu Ser Cys Thr Trp Ala Leu Glu Thr Leu Gly 
            20                  25                  30          


Gly Leu Asp Thr Ile Val Lys Ile Pro Pro His Val Leu Arg Glu Lys 
        35                  40                  45              


Cys Leu Leu Pro Leu Gln Leu Ala Leu Glu Ser Lys Asn Val Lys Leu 
    50                  55                  60                  


Ala Gln His Ala Leu Ala Gly Met Gln Lys Leu Leu Ser Glu Glu Arg 
65                  70                  75                  80  


Phe Val Ser Met Glu Thr Asp Ser Asp Glu Lys Gln Leu Leu Asn Gln 
                85                  90                  95      


Ile Leu Asn Ala Val Lys Val Thr Pro Ser Leu Asn Glu Asp Leu Gln 
            100                 105                 110         


Val Glu Val Met Lys Val Leu Leu Cys Ile Thr Tyr Thr Pro Thr Phe 
        115                 120                 125             


Asp Leu Asn Gly Ser Ala Val Leu Lys Ile Ala Glu Val Cys Ile Glu 
    130                 135                 140                 


Thr Tyr Ile Ser Ser Cys His Gln Arg Ser Ile Asn Thr Ala Val Arg 
145                 150                 155                 160 


Ala Thr Leu Ser Gln Met Leu Ser Asp Leu Thr Leu Gln Leu Arg Gln 
                165                 170                 175     


Arg Gln Glu Asn Thr Ile Ile Glu Asn Pro Asp Val Pro Gln Asp Phe 
            180                 185                 190         


Gly Asn Gln Gly Ser Thr Val Glu Ser Leu Cys Asp Asp Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu Cys Glu Lys Leu Gln Ala Ala Ile Asn Asp Ser 
    210                 215                 220                 


Gln Gln Leu Gln Leu Leu Tyr Leu Glu Cys Ile Leu Ser Val Leu Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Met His Leu His Arg Arg Phe Thr Asp Leu Ile 
                245                 250                 255     


Trp Lys Asn Leu Cys Pro Ala Leu Ile Val Ile Leu Gly Asn Pro Ile 
            260                 265                 270         


His Asp Lys Thr Ile Thr Ser Ala His Thr Ser Ser Thr Ser Thr Ser 
        275                 280                 285             


Leu Glu Ser Asp Ser Ala Ser Pro Gly Val Ser Asp His Gly Arg Gly 
    290                 295                 300                 


Ser Gly Cys Ser Cys Thr Ala Pro Ala Leu Ser Gly Pro Val Ala Arg 
305                 310                 315                 320 


Thr Ile Tyr Tyr Ile Ala Ala Glu Leu Val Arg Leu Val Gly Ser Val 
                325                 330                 335     


Asp Ser Met Lys Pro Val Leu Gln Ser Leu Tyr His Arg Val Leu Leu 
            340                 345                 350         


Tyr Pro Pro Pro Gln His Arg Val Glu Ala Ile Lys Ile Met Lys Glu 
        355                 360                 365             


Ile Leu Gly Ser Pro Gln Arg Leu Cys Asp Leu Ala Gly Pro Ser Ser 
    370                 375                 380                 


Thr Glu Ser Glu Ser Arg Lys Arg Ser Ile Ser Lys Arg Lys Ser His 
385                 390                 395                 400 


Leu Asp Leu Leu Lys Leu Ile Met Asp Gly Met Thr Glu Ala Cys Ile 
                405                 410                 415     


Lys Gly Gly Ile Glu Ala Cys Tyr Ala Ala Val Ser Cys Val Cys Thr 
            420                 425                 430         


Leu Leu Gly Ala Leu Asp Glu Leu Ser Gln Gly Lys Gly Leu Ser Glu 
        435                 440                 445             


Gly Gln Val Gln Leu Leu Leu Leu Arg Leu Glu Glu Leu Lys Asp Gly 
    450                 455                 460                 


Ala Glu Trp Ser Arg Asp Ser Met Glu Ile Asn Glu Ala Asp Phe Arg 
465                 470                 475                 480 


Trp Gln Arg Arg Val Leu Ser Ser Glu His Thr Pro Trp Glu Ser Gly 
                485                 490                 495     


Asn Glu Arg Ser Leu Asp Ile Ser Ile Ser Val Thr Thr Asp Thr Gly 
            500                 505                 510         


Gln Thr Thr Leu Glu Gly Glu Leu Gly Gln Thr Thr Pro Glu Asp His 
        515                 520                 525             


Ser Gly Asn His Lys Asn Ser Leu Lys Ser Pro Ala Ile Pro Glu Gly 
    530                 535                 540                 


Lys Glu Thr Leu Ser Lys Val Leu Glu Thr Glu Ala Val Asp Gln Pro 
545                 550                 555                 560 


Asp Val Val Gln Arg Ser His Thr Val Pro Tyr Pro Asp Ile Thr Asn 
                565                 570                 575     


Phe Leu Ser Val Asp Cys Arg Thr Arg Ser Tyr Gly Ser Arg Tyr Ser 
            580                 585                 590         


Glu Ser Asn Phe Ser Val Asp Asp Gln Asp Leu Ser Arg Thr Glu Phe 
        595                 600                 605             


Asp Ser Cys Asp Gln Tyr Ser Met Ala Ala Glu Lys Asp Ser Gly Arg 
    610                 615                 620                 


Ser Asp Val Ser Asp Ile Gly Ser Asp Asn Cys Ser Leu Ala Asp Glu 
625                 630                 635                 640 


Glu Gln Thr Pro Arg Asp Cys Leu Gly His Arg Ser Leu Arg Thr Ala 
                645                 650                 655     


Ala Leu Ser Leu Lys Leu Leu Lys Asn Gln Glu Ala Asp Gln His Ser 
            660                 665                 670         


Ala Arg Leu Phe Ile Gln Ser Leu Glu Gly Leu Leu Pro Arg Leu Leu 
        675                 680                 685             


Ser Leu Ser Asn Val Glu Glu Val Asp Thr Ala Leu Gln Asn Phe Ala 
    690                 695                 700                 


Ser Thr Phe Cys Ser Gly Met Met His Ser Pro Gly Phe Asp Gly Asn 
705                 710                 715                 720 


Ser Ser Leu Ser Phe Gln Met Leu Met Asn Ala Asp Ser Leu Tyr Thr 
                725                 730                 735     


Ala Ala His Cys Ala Leu Leu Leu Asn Leu Lys Leu Ser His Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Lys Arg Pro Thr Leu Ala Pro Gly Val Met Lys Asp Phe 
        755                 760                 765             


Met Lys Gln Val Gln Thr Ser Gly Val Leu Met Val Phe Ser Gln Ala 
    770                 775                 780                 


Trp Ile Glu Glu Leu Tyr His Gln Val Leu Asp Arg Asn Met Leu Gly 
785                 790                 795                 800 


Glu Ala Gly Tyr Trp Gly Ser Pro Glu Asp Asn Ser Leu Pro Leu Ile 
                805                 810                 815     


Thr Met Leu Thr Asp Ile Asp Gly Leu Glu Ser Ser Ala Ile Gly Gly 
            820                 825                 830         


Gln Leu Met Ala Ser Ala Ala Thr Glu Ser Pro Phe Ala Gln Ser Arg 
        835                 840                 845             


Arg Ile Asp Asp Ser Thr Val Ala Gly Val Ala Phe Ala Arg Tyr Ile 
    850                 855                 860                 


Leu Val Gly Cys Trp Lys Asn Leu Ile Asp Thr Leu Ser Thr Pro Leu 
865                 870                 875                 880 


Thr Gly Arg Met Ala Gly Ser Ser Lys Gly Leu Ala Phe Ile Leu Gly 
                885                 890                 895     


Ala Glu Gly Ile Lys Glu Gln Asn Gln Lys Glu Arg Asp Ala Ile Cys 
            900                 905                 910         


Met Ser Leu Asp Gly Leu Arg Lys Ala Ala Arg Leu Ser Cys Ala Leu 
        915                 920                 925             


Gly Val Ala Ala Asn Cys Ala Ser Ala Leu Ala Gln Met Ala Ala Ala 
    930                 935                 940                 


Ser Cys Val Gln Glu Glu Lys Glu Glu Arg Glu Ala Gln Glu Pro Ser 
945                 950                 955                 960 


Asp Ala Ile Thr Gln Val Lys Leu Lys Val Glu Gln Lys Leu Glu Gln 
                965                 970                 975     


Ile Gly Lys Val Gln Gly Val Trp Leu His Thr Ala His Val Leu Cys 
            980                 985                 990         


Met Glu Ala Ile Leu Ser Val Gly  Leu Glu Met Gly Ser  His Asn Pro 
        995                 1000                 1005             


Asp Cys  Trp Pro His Val Phe  Arg Val Cys Glu Tyr  Val Gly Thr 
    1010                 1015                 1020             


Leu Glu  His Asn His Phe Ser  Asp Gly Ala Ser Gln  Pro Pro Leu 
    1025                 1030                 1035             


Thr Ile  Ser Gln Pro Gln Lys  Ala Thr Gly Ser Ala  Gly Leu Leu 
    1040                 1045                 1050             


Gly Asp  Pro Glu Cys Glu Gly  Ser Pro Pro Glu His  Ser Pro Glu 
    1055                 1060                 1065             


Gln Gly  Arg Ser Leu Ser Thr  Ala Pro Val Val Gln  Pro Leu Ser 
    1070                 1075                 1080             


Ile Gln  Asp Leu Val Arg Glu  Gly Ser Arg Gly Arg  Ala Ser Asp 
    1085                 1090                 1095             


Phe Arg  Gly Gly Ser Leu Met  Ser Gly Ser Ser Ala  Ala Lys Val 
    1100                 1105                 1110             


Val Leu  Thr Leu Ser Thr Gln  Ala Asp Arg Leu Phe  Glu Asp Ala 
    1115                 1120                 1125             


Thr Asp  Lys Leu Asn Leu Met  Ala Leu Gly Gly Phe  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Lys  Lys Ala Ser Gln Ser  Gln Leu Phe His Ser  Val Thr Asp 
    1145                 1150                 1155             


Thr Val  Asp Tyr Ser Leu Ala  Met Pro Gly Glu Val  Lys Ser Thr 
    1160                 1165                 1170             


Gln Asp  Arg Lys Ser Ala Leu  His Leu Phe Arg Leu  Gly Asn Ala 
    1175                 1180                 1185             


Met Leu  Arg Ile Val Arg Ser  Lys Ala Arg Pro Leu  Leu His Val 
    1190                 1195                 1200             


Met Arg  Cys Trp Ser Leu Val  Ala Pro His Leu Val  Glu Ala Ala 
    1205                 1210                 1215             


Cys His  Lys Glu Arg His Val  Ser Gln Lys Ala Val  Ser Phe Ile 
    1220                 1225                 1230             


His Asp  Ile Leu Thr Glu Val  Leu Thr Asp Trp Asn  Glu Pro Pro 
    1235                 1240                 1245             


His Phe  His Phe Asn Glu Ala  Leu Phe Arg Pro Phe  Glu Arg Ile 
    1250                 1255                 1260             


Met Gln  Leu Glu Leu Cys Asp  Glu Asp Val Gln Asp  Gln Val Val 
    1265                 1270                 1275             


Thr Ser  Ile Gly Glu Leu Val  Glu Val Cys Ser Thr  Gln Ile Gln 
    1280                 1285                 1290             


Ser Gly  Trp Arg Pro Leu Phe  Ser Ala Leu Glu Thr  Val His Gly 
    1295                 1300                 1305             


Gly Asn  Lys Ser Glu Met Lys  Glu Tyr Leu Val Gly  Asp Tyr Ser 
    1310                 1315                 1320             


Met Gly  Lys Gly Gln Ala Pro  Val Phe Asp Val Phe  Glu Ala Phe 
    1325                 1330                 1335             


Leu Asn  Thr Asp Asn Ile Gln  Val Phe Ala Asn Ala  Ala Thr Ser 
    1340                 1345                 1350             


Tyr Ile  Met Cys Leu Met Lys  Phe Val Lys Gly Leu  Gly Glu Val 
    1355                 1360                 1365             


Asp Cys  Lys Glu Ile Gly Asp  Cys Ala Pro Ala Pro  Gly Ala Pro 
    1370                 1375                 1380             


Ser Thr  Asp Leu Cys Leu Pro  Ala Leu Asp Tyr Leu  Arg Arg Cys 
    1385                 1390                 1395             


Ser Gln  Leu Leu Ala Lys Ile  Tyr Lys Met Pro Leu  Lys Pro Ile 
    1400                 1405                 1410             


Phe Leu  Ser Gly Arg Leu Ala  Gly Leu Pro Arg Arg  Leu Gln Glu 
    1415                 1420                 1425             


Gln Ser  Ala Ser Ser Glu Asp  Gly Ile Glu Ser Val  Leu Ser Asp 
    1430                 1435                 1440             


Phe Asp  Asp Asp Thr Gly Leu  Ile Glu Val Trp Ile  Ile Leu Leu 
    1445                 1450                 1455             


Glu Gln  Leu Thr Ala Ala Val  Ser Asn Cys Pro Arg  Gln His Gln 
    1460                 1465                 1470             


Pro Pro  Thr Leu Asp Leu Leu  Phe Glu Leu Leu Arg  Asp Val Thr 
    1475                 1480                 1485             


Lys Thr  Pro Gly Pro Gly Phe  Gly Ile Tyr Ala Val  Val His Leu 
    1490                 1495                 1500             


Leu Leu  Pro Val Met Ser Val  Trp Leu Arg Arg Ser  His Lys Asp 
    1505                 1510                 1515             


His Ser  Tyr Trp Asp Met Ala  Ser Ala Asn Phe Lys  His Ala Ile 
    1520                 1525                 1530             


Gly Leu  Ser Cys Glu Leu Val  Val Glu His Ile Gln  Ser Phe Leu 
    1535                 1540                 1545             


His Ser  Asp Ile Arg Tyr Glu  Ser Met Ile Asn Thr  Met Leu Lys 
    1550                 1555                 1560             


Asp Leu  Phe Glu Leu Leu Val  Ala Cys Val Ala Lys  Pro Thr Glu 
    1565                 1570                 1575             


Thr Ile  Ser Arg Val Gly Cys  Ser Cys Ile Arg Tyr  Val Leu Val 
    1580                 1585                 1590             


Thr Ala  Gly Pro Val Phe Thr  Glu Glu Met Trp Arg  Leu Ala Cys 
    1595                 1600                 1605             


Cys Ala  Leu Gln Asp Ala Phe  Ser Ala Thr Leu Lys  Pro Val Lys 
    1610                 1615                 1620             


Asp Leu  Leu Gly Cys Phe His  Ser Gly Thr Glu Ser  Phe Ser Gly 
    1625                 1630                 1635             


Glu Gly  Cys Gln Val Arg Val  Ala Ala Pro Ser Ser  Ser Pro Ser 
    1640                 1645                 1650             


Ala Glu  Ala Glu Tyr Trp Arg  Ile Arg Ala Met Ala  Gln Gln Val 
    1655                 1660                 1665             


Phe Met  Leu Asp Thr Gln Cys  Ser Pro Lys Thr Pro  Asn Asn Phe 
    1670                 1675                 1680             


Asp His  Ala Gln Ser Cys Gln  Leu Ile Ile Glu Leu  Pro Pro Asp 
    1685                 1690                 1695             


Glu Lys  Pro Asn Gly His Thr  Lys Lys Ser Val Ser  Phe Arg Glu 
    1700                 1705                 1710             


Ile Val  Val Ser Leu Leu Ser  His Gln Val Leu Leu  Gln Asn Leu 
    1715                 1720                 1725             


Tyr Asp  Ile Leu Leu Glu Glu  Phe Val Lys Gly Pro  Ser Pro Gly 
    1730                 1735                 1740             


Glu Glu  Lys Thr Ile Gln Val  Pro Glu Ala Lys Leu  Ala Gly Phe 
    1745                 1750                 1755             


Leu Arg  Tyr Ile Ser Met Gln  Asn Leu Ala Val Ile  Phe Asp Leu 
    1760                 1765                 1770             


Leu Leu  Asp Ser Tyr Arg Thr  Ala Arg Glu Phe Asp  Thr Ser Pro 
    1775                 1780                 1785             


Gly Leu  Lys Cys Leu Leu Lys  Lys Val Ser Gly Ile  Gly Gly Ala 
    1790                 1795                 1800             


Ala Asn  Leu Tyr Arg Gln Ser  Ala Met Ser Phe Asn  Ile Tyr Phe 
    1805                 1810                 1815             


His Ala  Leu Val Cys Ala Val  Leu Thr Asn Gln Glu  Thr Ile Thr 
    1820                 1825                 1830             


Ala Glu  Gln Val Lys Lys Val  Leu Phe Glu Asp Asp  Glu Arg Ser 
    1835                 1840                 1845             


Thr Asp  Ser Ser Gln Gln Cys  Ser Ser Glu Asp Glu  Asp Ile Phe 
    1850                 1855                 1860             


Glu Glu  Thr Ala Gln Val Ser  Pro Pro Arg Gly Lys  Glu Lys Arg 
    1865                 1870                 1875             


Gln Trp  Arg Ala Arg Met Pro  Leu Leu Ser Val Gln  Pro Val Ser 
    1880                 1885                 1890             


Asn Ala  Asp Trp Val Trp Leu  Val Lys Arg Leu His  Lys Leu Cys 
    1895                 1900                 1905             


Met Glu  Leu Cys Asn Asn Tyr  Ile Gln Met His Leu  Asp Leu Glu 
    1910                 1915                 1920             


Asn Cys  Met Glu Glu Pro Pro  Ile Phe Lys Gly Asp  Pro Phe Phe 
    1925                 1930                 1935             


Ile Leu  Pro Ser Phe Gln Ser  Glu Ser Ser Thr Pro  Ser Thr Gly 
    1940                 1945                 1950             


Gly Phe  Ser Gly Lys Glu Thr  Pro Ser Glu Asp Asp  Arg Ser Gln 
    1955                 1960                 1965             


Ser Arg  Glu His Met Gly Glu  Ser Leu Ser Leu Lys  Ala Gly Gly 
    1970                 1975                 1980             


Gly Asp  Leu Leu Leu Pro Pro  Ser Pro Lys Val Glu  Lys Lys Asp 
    1985                 1990                 1995             


Pro Ser  Arg Lys Lys Glu Trp  Trp Glu Asn Ala Gly  Asn Lys Ile 
    2000                 2005                 2010             


Tyr Thr  Met Ala Ala Asp Lys  Thr Ile Ser Lys Leu  Met Thr Glu 
    2015                 2020                 2025             


Tyr Lys  Lys Arg Lys Gln Gln  His Asn Leu Ser Ala  Phe Pro Lys 
    2030                 2035                 2040             


Glu Val  Lys Val Glu Lys Lys  Gly Glu Pro Leu Gly  Pro Arg Gly 
    2045                 2050                 2055             


Gln Asp  Ser Pro Leu Leu Gln  Arg Pro Gln His Leu  Met Asp Gln 
    2060                 2065                 2070             


Gly Gln  Met Arg His Ser Phe  Ser Ala Gly Pro Glu  Leu Leu Arg 
    2075                 2080                 2085             


Gln Asp  Lys Arg Pro Arg Ser  Gly Ser Thr Gly Ser  Ser Leu Ser 
    2090                 2095                 2100             


Val Ser  Val Arg Asp Ala Glu  Ala Gln Ile Gln Ala  Trp Thr Asn 
    2105                 2110                 2115             


Met Val  Leu Thr Val Leu Asn  Gln Ile Gln Ile Leu  Pro Asp Gln 
    2120                 2125                 2130             


Thr Phe  Thr Ala Leu Gln Pro  Ala Val Phe Pro Cys  Ile Ser Gln 
    2135                 2140                 2145             


Leu Thr  Cys His Val Thr Asp  Ile Arg Val Arg Gln  Ala Val Arg 
    2150                 2155                 2160             


Glu Trp  Leu Gly Arg Val Gly  Arg Val Tyr Asp Ile  Ile Val 
    2165                 2170                 2175         


<210>  701
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFIP1__Homo_sapiens__NP_001020766

<400>  701

Met Ala Gln Glu Ser Pro Lys Asn Ser Ala Ala Glu Ile Pro Val Thr 
1               5                   10                  15      


Ser Asn Gly Glu Val Asp Asp Ser Arg Glu His Ser Phe Asn Arg Asp 
            20                  25                  30          


Leu Lys His Ser Leu Pro Ser Gly Leu Gly Leu Ser Glu Thr Gln Ile 
        35                  40                  45              


Thr Ser His Gly Phe Asp Asn Thr Lys Glu Gly Val Ile Glu Ala Gly 
    50                  55                  60                  


Ala Phe Gln Gly Ser Pro Ala Pro Pro Leu Pro Ser Val Met Ser Pro 
65                  70                  75                  80  


Ser Arg Val Ala Ala Ser Arg Leu Ala Gln Gln Gly Ser Asp Leu Ile 
                85                  90                  95      


Val Pro Ala Gly Gly Gln Arg Thr Gln Thr Lys Ser Gly Pro Val Ile 
            100                 105                 110         


Leu Ala Asp Glu Ile Lys Asn Pro Ala Met Glu Lys Leu Glu Leu Val 
        115                 120                 125             


Arg Lys Trp Ser Leu Asn Thr Tyr Lys Cys Thr Arg Gln Ile Ile Ser 
    130                 135                 140                 


Glu Lys Leu Gly Arg Gly Ser Arg Thr Val Asp Leu Glu Leu Glu Ala 
145                 150                 155                 160 


Gln Ile Asp Ile Leu Arg Asp Asn Lys Lys Lys Tyr Glu Asn Ile Leu 
                165                 170                 175     


Lys Leu Ala Gln Thr Leu Ser Thr Gln Leu Phe Gln Met Val His Thr 
            180                 185                 190         


Gln Arg Gln Leu Gly Asp Ala Phe Ala Asp Leu Ser Leu Lys Ser Leu 
        195                 200                 205             


Glu Leu His Glu Glu Phe Gly Tyr Asn Ala Asp Thr Gln Lys Leu Leu 
    210                 215                 220                 


Ala Lys Asn Gly Glu Thr Leu Leu Gly Ala Ile Asn Phe Phe Ile Ala 
225                 230                 235                 240 


Ser Val Asn Thr Leu Val Asn Lys Thr Ile Glu Asp Thr Leu Met Thr 
                245                 250                 255     


Val Lys Gln Tyr Glu Ser Ala Arg Ile Glu Tyr Asp Ala Tyr Arg Thr 
            260                 265                 270         


Asp Leu Glu Glu Leu Asn Leu Gly Pro Arg Asp Ala Asn Thr Leu Pro 
        275                 280                 285             


Lys Ile Glu Gln Ser Gln His Leu Phe Gln Ala His Lys Glu Lys Tyr 
    290                 295                 300                 


Asp Lys Met Arg Asn Asp Val Ser Val Lys Leu Lys Phe Leu Glu Glu 
305                 310                 315                 320 


Asn Lys Val Lys Val Leu His Asn Gln Leu Val Leu Phe His Asn Ala 
                325                 330                 335     


Ile Ala Ala Tyr Phe Ala Gly Asn Gln Lys Gln Leu Glu Gln Thr Leu 
            340                 345                 350         


Lys Gln Phe His Ile Lys Leu Lys Thr Pro Gly Val Asp Ala Pro Ser 
        355                 360                 365             


Trp Leu Glu Glu Gln 
    370             


<210>  702
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARFRP1__Homo_sapiens__NP_001128230

<400>  702

Met Tyr Thr Leu Leu Ser Gly Leu Tyr Lys Tyr Met Phe Gln Lys Asp 
1               5                   10                  15      


Glu Tyr Cys Ile Leu Ile Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
            20                  25                  30          


Phe Leu Glu Gln Ser Lys Thr Arg Phe Asn Lys Asn Tyr Lys Gly Met 
        35                  40                  45              


Ser Leu Ser Lys Ile Thr Thr Thr Val Gly Leu Asn Ile Gly Thr Val 
    50                  55                  60                  


Asp Val Gly Lys Ala Arg Leu Met Phe Trp Asp Leu Gly Gly Gln Glu 
65                  70                  75                  80  


Glu Leu Gln Ser Leu Trp Asp Lys Tyr Tyr Ala Glu Cys His Gly Val 
                85                  90                  95      


Ile Tyr Val Ile Asp Ser Thr Asp Glu Glu Arg Leu Ala Glu Ser Lys 
            100                 105                 110         


Gln Ala Phe Glu Lys Val Val Thr Ser Glu Ala Leu Cys Gly Val Pro 
        115                 120                 125             


Val Leu Val Leu Ala Asn Lys Gln Asp Val Glu Thr Cys Leu Ser Ile 
    130                 135                 140                 


Pro Asp Ile Lys Thr Ala Phe Ser Asp Cys Thr Ser Lys Ile Gly Arg 
145                 150                 155                 160 


Arg Asp Cys Leu Thr Gln Ala Cys Ser Ala Leu Thr Gly 
                165                 170             


<210>  703
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARG1__Homo_sapiens__NP_000036

<400>  703

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile 
        195                 200                 205             


Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys 
    210                 215                 220                 


Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe 
225                 230                 235                 240 


Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu 
                245                 250                 255     


Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly 
            260                 265                 270         


Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu 
        275                 280                 285             


Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe 
    290                 295                 300                 


Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro 
305                 310                 315                 320 


Pro Lys 
        


<210>  704
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARGLU1__Homo_sapiens__NP_060481

<400>  704

Met Gly Arg Ser Arg Ser Arg Ser Ser Ser Arg Ser Lys His Thr Lys 
1               5                   10                  15      


Ser Ser Lys His Asn Lys Lys Arg Ser Arg Ser Arg Ser Arg Ser Arg 
            20                  25                  30          


Asp Lys Glu Arg Val Arg Lys Arg Ser Lys Ser Arg Glu Ser Lys Arg 
        35                  40                  45              


Asn Arg Arg Arg Glu Ser Arg Ser Arg Ser Arg Ser Thr Asn Thr Ala 
    50                  55                  60                  


Val Ser Arg Arg Glu Arg Asp Arg Glu Arg Ala Ser Ser Pro Pro Asp 
65                  70                  75                  80  


Arg Ile Asp Ile Phe Gly Arg Thr Val Ser Lys Arg Ser Ser Leu Asp 
                85                  90                  95      


Glu Lys Gln Lys Arg Glu Glu Glu Glu Lys Lys Ala Glu Phe Glu Arg 
            100                 105                 110         


Gln Arg Lys Ile Arg Gln Gln Glu Ile Glu Glu Lys Leu Ile Glu Glu 
        115                 120                 125             


Glu Thr Ala Arg Arg Val Glu Glu Leu Val Ala Lys Arg Val Glu Glu 
    130                 135                 140                 


Glu Leu Glu Lys Arg Lys Asp Glu Ile Glu Arg Glu Val Leu Arg Arg 
145                 150                 155                 160 


Val Glu Glu Ala Lys Arg Ile Met Glu Lys Gln Leu Leu Glu Glu Leu 
                165                 170                 175     


Glu Arg Gln Arg Gln Ala Glu Leu Ala Ala Gln Lys Ala Arg Glu Glu 
            180                 185                 190         


Glu Glu Arg Ala Lys Arg Glu Glu Leu Glu Arg Ile Leu Glu Glu Asn 
        195                 200                 205             


Asn Arg Lys Ile Ala Glu Ala Gln Ala Lys Leu Ala Glu Glu Gln Leu 
    210                 215                 220                 


Arg Ile Val Glu Glu Gln Arg Lys Ile His Glu Glu Arg Met Lys Leu 
225                 230                 235                 240 


Glu Gln Glu Arg Gln Arg Gln Gln Lys Glu Glu Gln Lys Ile Ile Leu 
                245                 250                 255     


Gly Lys Gly Lys Ser Arg Pro Lys Leu Ser Phe Ser Leu Lys Thr Gln 
            260                 265                 270         


Asp 
    


<210>  705
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP10__Homo_sapiens__NP_078881

<400>  705

Met Gly Leu Gln Pro Leu Glu Phe Ser Asp Cys Tyr Leu Asp Ser Pro 
1               5                   10                  15      


Trp Phe Arg Glu Arg Ile Arg Ala His Glu Ala Glu Leu Glu Arg Thr 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Lys Asn Leu Ile Ala 
        35                  40                  45              


Ala Thr Lys Ser Leu Ser Val Ala Gln Arg Lys Phe Ala His Ser Leu 
    50                  55                  60                  


Arg Asp Phe Lys Phe Glu Phe Ile Gly Asp Ala Val Thr Asp Asp Glu 
65                  70                  75                  80  


Arg Cys Ile Asp Ala Ser Leu Arg Glu Phe Ser Asn Phe Leu Lys Asn 
                85                  90                  95      


Leu Glu Glu Gln Arg Glu Ile Met Ala Leu Ser Val Thr Glu Thr Leu 
            100                 105                 110         


Ile Lys Pro Leu Glu Lys Phe Arg Lys Glu Gln Leu Gly Ala Val Lys 
        115                 120                 125             


Glu Glu Lys Lys Lys Phe Asp Lys Glu Thr Glu Lys Asn Tyr Ser Leu 
    130                 135                 140                 


Ile Asp Lys His Leu Asn Leu Ser Ala Lys Lys Lys Asp Ser His Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Ile Gln Val Glu Gln Asn Arg Gln His Phe Tyr Glu 
                165                 170                 175     


Leu Ser Leu Glu Tyr Val Cys Lys Leu Gln Glu Ile Gln Glu Arg Lys 
            180                 185                 190         


Lys Phe Glu Phe Val Glu Pro Met Leu Ser Phe Phe Gln Gly Met Phe 
        195                 200                 205             


Thr Phe Tyr His Gln Gly His Glu Leu Ala Lys Asp Phe Asn His Tyr 
    210                 215                 220                 


Lys Met Glu Leu Gln Ile Asn Ile Gln Asn Thr Arg Asn Arg Phe Glu 
225                 230                 235                 240 


Gly Thr Arg Ser Glu Val Glu Glu Leu Met Asn Lys Ile Arg Gln Asn 
                245                 250                 255     


Pro Lys Asp His Lys Arg Ala Ser Gln Phe Thr Ala Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg Pro Ala Pro Phe Gly Ser Ser Trp Val Lys 
        275                 280                 285             


His Tyr Cys Met Tyr Arg Lys Ala Ala Lys Lys Phe Asn Met Ile Pro 
    290                 295                 300                 


Phe Glu His Arg Ser Gly Gly Lys Leu Gly Asp Gly Glu Val Phe Phe 
305                 310                 315                 320 


Leu Lys Glu Cys Thr Lys Arg His Thr Asp Ser Ile Asp Arg Arg Phe 
                325                 330                 335     


Cys Phe Asp Ile Glu Ala Ala Asp Arg Pro Gly Val Ser Leu Thr Met 
            340                 345                 350         


Gln Ala Phe Ser Glu Glu Glu Arg Lys Gln Trp Leu Glu Ala Leu Gly 
        355                 360                 365             


Gly Lys Glu Ala Leu Ser His Ser Phe Asn Thr Ala Ile Ile Pro Arg 
    370                 375                 380                 


Pro Glu Gly Asn Ala Gln Leu Asp Lys Met Gly Phe Thr Ile Ile Arg 
385                 390                 395                 400 


Lys Cys Ile Ser Ala Val Glu Thr Arg Gly Ile Asn Asp Gln Gly Leu 
                405                 410                 415     


Tyr Arg Val Val Gly Val Ser Ser Lys Val Gln Arg Leu Leu Ser Met 
            420                 425                 430         


Leu Met Asp Val Lys Thr Cys Asn Glu Val Asp Leu Glu Asn Ser Ala 
        435                 440                 445             


Asp Trp Glu Val Lys Thr Ile Thr Ser Ala Leu Lys Gln Tyr Leu Arg 
    450                 455                 460                 


Ser Leu Pro Glu Pro Leu Met Thr Tyr Glu Leu His Gly Asp Phe Ile 
465                 470                 475                 480 


Val Pro Ala Lys Ser Gly Ser Pro Glu Ser Arg Val Asn Ala Ile His 
                485                 490                 495     


Phe Leu Val His Lys Leu Pro Glu Lys Asn Lys Glu Met Leu Asp Ile 
            500                 505                 510         


Leu Val Lys His Leu Thr Asn Val Ser Asn His Ser Lys Gln Asn Leu 
        515                 520                 525             


Met Thr Val Ala Asn Leu Gly Val Val Phe Gly Pro Thr Leu Met Arg 
    530                 535                 540                 


Pro Gln Glu Glu Thr Val Ala Ala Leu Met Asp Leu Lys Phe Gln Asn 
545                 550                 555                 560 


Ile Val Val Glu Ile Leu Ile Glu Asn His Glu Lys Ile Phe Arg Thr 
                565                 570                 575     


Pro Pro Asp Thr Thr Phe Pro Glu Pro Thr Cys Leu Ser Ala Ser Pro 
            580                 585                 590         


Pro Asn Ala Pro Pro Arg Gln Ser Lys Arg Gln Gly Gln Arg Thr Lys 
        595                 600                 605             


Arg Pro Val Ala Val Tyr Asn Leu Cys Leu Glu Leu Glu Asp Gly Asp 
    610                 615                 620                 


Asn Pro Tyr Pro Ser Lys Glu Asp Thr Pro Thr Ser Ser Leu Asp Ser 
625                 630                 635                 640 


Leu Ser Ser Pro Ser Pro Val Thr Thr Ala Val Pro Gly Pro Pro Gly 
                645                 650                 655     


Pro Asp Lys Asn His Leu Leu Ala Asp Gly Gly Ser Phe Gly Asp Trp 
            660                 665                 670         


Ala Ser Thr Ile Pro Gly Gln Thr Arg Ser Ser Met Val Gln Trp Leu 
        675                 680                 685             


Asn Pro Gln Ser Pro Thr Thr Thr Ser Ser Asn Ser Ala Val Thr Pro 
    690                 695                 700                 


Leu Ser Pro Gly Ser Ser Pro Phe Pro Phe Ser Pro Pro Ala Thr Val 
705                 710                 715                 720 


Ala Asp Lys Pro Pro Glu Ser Ile Arg Ser Arg Lys Ala Arg Ala Val 
                725                 730                 735     


Tyr Pro Cys Glu Ala Glu His Ser Ser Glu Leu Ser Phe Glu Ile Gly 
            740                 745                 750         


Ala Ile Phe Glu Asp Val Gln Thr Ser Arg Glu Pro Gly Trp Leu Glu 
        755                 760                 765             


Gly Thr Leu Asn Gly Lys Arg Gly Leu Ile Pro Gln Asn Tyr Val Lys 
    770                 775                 780                 


Leu Leu 
785     


<210>  706
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP11A__Homo_sapiens__NP_001273408

<400>  706

Met Asp Ser Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln 
1               5                   10                  15      


Thr Ser Glu Gly His Glu Lys Met Ser Ser Asn Thr Glu Lys Lys Leu 
            20                  25                  30          


Arg Leu Gln Ala Ala Val Val Gln Thr Leu Ile Asp Tyr Ala Ser Asp 
        35                  40                  45              


Ile Gly Arg Val Pro Asp Phe Ile Leu Glu Lys Ile Pro Ala Met Leu 
    50                  55                  60                  


Gly Ile Asp Gly Leu Cys Ala Thr Pro Ser Leu Glu Gly Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Tyr Glu Thr Pro Gly Glu Tyr Lys Arg Lys Arg Arg Gln Ser 
                85                  90                  95      


Val Gly Asp Phe Val Ser Gly Ala Leu Asn Lys Phe Lys Pro Asn Arg 
            100                 105                 110         


Thr Pro Ser Ile Thr Pro Gln Glu Glu Arg Ile Ala Gln Leu Ser Glu 
        115                 120                 125             


Ser Pro Val Ile Leu Thr Pro Asn Ala Lys Arg Thr Leu Pro Val Asp 
    130                 135                 140                 


Ser Ser His Gly Phe Ser Ser Lys Lys Arg Lys Ser Ile Lys His Asn 
145                 150                 155                 160 


Phe Asn Phe Glu Leu Leu Pro Ser Asn Leu Phe Asn Ser Ser Ser Thr 
                165                 170                 175     


Pro Val Ser Val His Ile Asp Thr Ser Ser Glu Gly Ser Ser Gln Ser 
            180                 185                 190         


Ser Leu Ser Pro Val Leu Ile Gly Gly Asn His Leu Ile Thr Ala Gly 
        195                 200                 205             


Val Pro Arg Arg Ser Lys Arg Ile Ala Gly Lys Lys Val Cys Arg Val 
    210                 215                 220                 


Glu Ser Gly Lys Ala Gly Cys Phe Ser Pro Lys Ile Ser His Lys Glu 
225                 230                 235                 240 


Lys Val Arg Arg Ser Leu Arg Leu Lys Phe Asn Leu Gly Lys Asn Gly 
                245                 250                 255     


Arg Glu Val Asn Gly Cys Ser Gly Val Asn Arg Tyr Glu Ser Val Gly 
            260                 265                 270         


Trp Arg Leu Ala Asn Gln Gln Ser Leu Lys Asn Arg Ile Glu Ser Val 
        275                 280                 285             


Lys Thr Gly Leu Leu Phe Ser Pro Asp Val Asp Glu Lys Leu Pro Lys 
    290                 295                 300                 


Lys Gly Ser Glu Lys Ile Ser Lys Ser Glu Glu Thr Leu Leu Thr Pro 
305                 310                 315                 320 


Glu Arg Leu Val Gly Thr Asn Tyr Arg Met Ser Trp Thr Gly Pro Asn 
                325                 330                 335     


Asn Ser Ser Phe Gln Glu Val Asp Ala Asn Glu Ala Ser Ser Met Val 
            340                 345                 350         


Glu Asn Leu Glu Val Glu Asn Ser Leu Glu Pro Asp Ile Met Val Glu 
        355                 360                 365             


Lys Ser Pro Ala Thr Ser Cys Glu Leu Thr Pro Ser Asn Leu Asn Asn 
    370                 375                 380                 


Lys His Asn Ser Asn Ile Thr Ser Ser Pro Leu Ser Gly Asp Glu Asn 
385                 390                 395                 400 


Asn Met Thr Lys Glu Thr Leu Val Lys Val Gln Lys Ala Phe Ser Glu 
                405                 410                 415     


Ser Gly Ser Asn Leu His Ala Leu Met Asn Gln Arg Gln Ser Ser Val 
            420                 425                 430         


Thr Asn Val Gly Lys Val Lys Leu Thr Glu Pro Ser Tyr Leu Glu Asp 
        435                 440                 445             


Ser Pro Glu Glu Asn Leu Phe Glu Thr Asn Asp Leu Thr Ile Val Glu 
    450                 455                 460                 


Ser Lys Glu Lys Tyr Glu His His Thr Gly Lys Gly Glu Lys Cys Phe 
465                 470                 475                 480 


Ser Glu Arg Asp Phe Ser Pro Leu Gln Thr Gln Thr Phe Asn Arg Glu 
                485                 490                 495     


Thr Thr Ile Lys Cys Tyr Ser Thr Gln Met Lys Met Glu His Glu Lys 
            500                 505                 510         


Asp Ile His Ser Asn Met Pro Lys Asp Tyr Leu Ser Lys Gln Glu Phe 
        515                 520                 525             


Ser Ser Asp Glu Glu Ile Lys Lys Gln Gln Ser Pro Lys Asp Lys Leu 
    530                 535                 540                 


Asn Asn Lys Leu Lys Glu Asn Glu Asn Met Met Glu Gly Asn Leu Pro 
545                 550                 555                 560 


Lys Cys Ala Ala His Ser Lys Asp Glu Ala Arg Ser Ser Phe Ser Gln 
                565                 570                 575     


Gln Ser Thr Cys Val Val Thr Asn Leu Ser Lys Pro Arg Pro Met Arg 
            580                 585                 590         


Ile Ala Lys Gln Gln Ser Leu Glu Thr Cys Glu Lys Thr Val Ser Glu 
        595                 600                 605             


Ser Ser Gln Met Thr Glu His Arg Lys Val Ser Asp His Ile Gln Trp 
    610                 615                 620                 


Phe Asn Lys Leu Ser Leu Asn Glu Pro Asn Arg Ile Lys Val Lys Ser 
625                 630                 635                 640 


Pro Leu Lys Phe Gln Arg Thr Pro Val Arg Gln Ser Val Arg Arg Ile 
                645                 650                 655     


Asn Ser Leu Leu Glu Tyr Ser Arg Gln Pro Thr Gly His Lys Leu Ala 
            660                 665                 670         


Ser Leu Gly Asp Thr Ala Ser Pro Leu Val Lys Ser Val Ser Cys Asp 
        675                 680                 685             


Gly Ala Leu Ser Ser Cys Ile Glu Ser Ala Ser Lys Asp Ser Ser Val 
    690                 695                 700                 


Ser Cys Ile Lys Ser Gly Pro Lys Glu Gln Lys Ser Met Ser Cys Glu 
705                 710                 715                 720 


Glu Ser Asn Ile Gly Ala Ile Ser Lys Ser Ser Met Glu Leu Pro Ser 
                725                 730                 735     


Lys Ser Phe Leu Lys Met Arg Lys His Pro Asp Ser Val Asn Ala Ser 
            740                 745                 750         


Leu Arg Ser Thr Thr Val Tyr Lys Gln Lys Ile Leu Ser Asp Gly Gln 
        755                 760                 765             


Val Lys Val Pro Leu Asp Asp Leu Thr Asn His Asp Ile Val Lys Pro 
    770                 775                 780                 


Val Val Asn Asn Asn Met Gly Ile Ser Ser Gly Ile Asn Asn Arg Val 
785                 790                 795                 800 


Leu Arg Arg Pro Ser Glu Arg Gly Arg Ala Trp Tyr Lys Gly Ser Pro 
                805                 810                 815     


Lys His Pro Ile Gly Lys Thr Gln Leu Leu Pro Thr Ser Lys Pro Val 
            820                 825                 830         


Asp Leu 
        


<210>  707
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP11B__Homo_sapiens__NP_001034930

<400>  707

Met Trp Asp Gln Arg Leu Val Lys Leu Ala Leu Leu Gln His Leu Arg 
1               5                   10                  15      


Ala Phe Tyr Gly Ile Lys Val Lys Gly Val Arg Gly Gln Cys Asp Arg 
            20                  25                  30          


Arg Arg His Glu Thr Ala Ala Thr Glu Ile Gly Gly Lys Ile Phe Gly 
        35                  40                  45              


Val Pro Phe Asn Ala Leu Pro His Ser Ala Val Pro Glu Tyr Gly His 
    50                  55                  60                  


Ile Pro Ser Phe Leu Val Asp Ala Cys Thr Ser Leu Glu Glu His Ile 
65                  70                  75                  80  


His Thr Glu Gly Leu Phe Arg Lys Ser Gly Ser Val Ile Arg Leu Lys 
                85                  90                  95      


Ala Leu Lys Asn Lys Val Asp His Gly Glu Gly Cys Leu Ser Ser Ala 
            100                 105                 110         


Pro Pro Cys Asp Ile Ala Gly Leu Leu Lys Gln Phe Phe Arg Glu Leu 
        115                 120                 125             


Pro Glu Pro Ile Leu Pro Ala Asp Leu His Glu Ala Leu Leu Lys Ala 
    130                 135                 140                 


Gln Gln Leu Gly Thr Glu Glu Lys Asn Lys Ala Ile Leu Leu Leu Ser 
145                 150                 155                 160 


Cys Leu Leu Ala Asp His Thr Val His Val Leu Arg Tyr Phe Phe Asn 
                165                 170                 175     


Phe Leu Arg Asn Val Ser Leu Arg Ser Ser Glu Asn Lys Met Asp Ser 
            180                 185                 190         


Ser Asn Leu Ala Val Ile Phe Ala Pro Asn Leu Leu Gln Thr Ser Glu 
        195                 200                 205             


Gly His Glu Lys Met Ser Ser Asn Ala Glu Lys Lys Gly Val Tyr Gln 
    210                 215                 220                 


Thr Leu Ser Trp Lys Arg Tyr Gln Pro Cys Trp Val Leu Met Val Ser 
225                 230                 235                 240 


Val Leu Leu His His Trp Lys Ala Leu Lys Lys Val Asn Met Lys Leu 
                245                 250                 255     


Leu Val Asn Ile Arg Glu Arg Glu Asp Asn Val 
            260                 265         


<210>  708
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP15__Homo_sapiens__NP_060930

<400>  708

Met Gln Lys Ser Thr Asn Ser Asp Thr Ser Val Glu Thr Leu Asn Ser 
1               5                   10                  15      


Thr Arg Gln Gly Thr Gly Ala Val Gln Met Arg Ile Lys Asn Ala Asn 
            20                  25                  30          


Ser His His Asp Arg Leu Ser Gln Ser Lys Ser Met Ile Leu Thr Asp 
        35                  40                  45              


Val Gly Lys Val Thr Glu Pro Ile Ser Arg His Arg Arg Asn His Ser 
    50                  55                  60                  


Gln His Ile Leu Lys Asp Val Ile Pro Pro Leu Glu Gln Leu Met Val 
65                  70                  75                  80  


Glu Lys Glu Gly Tyr Leu Gln Lys Ala Lys Ile Ala Asp Gly Gly Lys 
                85                  90                  95      


Lys Leu Arg Lys Asn Trp Ser Thr Ser Trp Ile Val Leu Ser Ser Arg 
            100                 105                 110         


Arg Ile Glu Phe Tyr Lys Glu Ser Lys Gln Gln Ala Leu Ser Asn Met 
        115                 120                 125             


Lys Thr Gly His Lys Pro Glu Ser Val Asp Leu Cys Gly Ala His Ile 
    130                 135                 140                 


Glu Trp Ala Lys Glu Lys Ser Ser Arg Lys Asn Val Phe Gln Ile Thr 
145                 150                 155                 160 


Thr Val Ser Gly Asn Glu Phe Leu Leu Gln Ser Asp Ile Asp Phe Ile 
                165                 170                 175     


Ile Leu Asp Trp Phe His Ala Ile Lys Asn Ala Ile Asp Arg Leu Pro 
            180                 185                 190         


Lys Asp Ser Ser Cys Pro Ser Arg Asn Leu Glu Leu Phe Lys Ile Gln 
        195                 200                 205             


Arg Ser Ser Ser Thr Glu Leu Leu Ser His Tyr Asp Ser Asp Ile Lys 
    210                 215                 220                 


Glu Gln Lys Pro Glu His Arg Lys Ser Leu Met Phe Arg Leu His His 
225                 230                 235                 240 


Ser Ala Ser Asp Thr Ser Asp Lys Asn Arg Val Lys Ser Arg Leu Lys 
                245                 250                 255     


Lys Phe Ile Thr Arg Arg Pro Ser Leu Lys Thr Leu Gln Glu Lys Gly 
            260                 265                 270         


Leu Ile Lys Asp Gln Ile Phe Gly Ser His Leu His Lys Val Cys Glu 
        275                 280                 285             


Arg Glu Asn Ser Thr Val Pro Trp Phe Val Lys Gln Cys Ile Glu Ala 
    290                 295                 300                 


Val Glu Lys Arg Gly Leu Asp Val Asp Gly Ile Tyr Arg Val Ser Gly 
305                 310                 315                 320 


Asn Leu Ala Thr Ile Gln Lys Leu Arg Phe Ile Val Asn Gln Glu Glu 
                325                 330                 335     


Lys Leu Asn Leu Asp Asp Ser Gln Trp Glu Asp Ile His Val Val Thr 
            340                 345                 350         


Gly Ala Leu Lys Met Phe Phe Arg Glu Leu Pro Glu Pro Leu Phe Pro 
        355                 360                 365             


Tyr Ser Phe Phe Glu Gln Phe Val Glu Ala Ile Lys Lys Gln Asp Asn 
    370                 375                 380                 


Asn Thr Arg Ile Glu Ala Val Lys Ser Leu Val Gln Lys Leu Pro Pro 
385                 390                 395                 400 


Pro Asn Arg Asp Thr Met Lys Val Leu Phe Gly His Leu Thr Lys Ile 
                405                 410                 415     


Val Ala Lys Ala Ser Lys Asn Leu Met Ser Thr Gln Ser Leu Gly Ile 
            420                 425                 430         


Val Phe Gly Pro Thr Leu Leu Arg Ala Glu Asn Glu Thr Gly Asn Met 
        435                 440                 445             


Ala Ile His Met Val Tyr Gln Asn Gln Ile Ala Glu Leu Met Leu Ser 
    450                 455                 460                 


Glu Tyr Ser Lys Ile Phe Gly Ser Glu Glu Asp 
465                 470                 475 


<210>  709
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP18__Homo_sapiens__NP_277050

<400>  709

Met Ser Trp Leu Ser Ser Ser Gln Gly Val Val Leu Thr Ala Tyr His 
1               5                   10                  15      


Pro Ser Gly Lys Asp Gln Thr Val Gly Asn Ser His Ala Lys Ala Gly 
            20                  25                  30          


Glu Glu Ala Thr Ser Ser Arg Arg Tyr Gly Gln Tyr Thr Met Asn Gln 
        35                  40                  45              


Glu Ser Thr Thr Ile Lys Val Met Glu Lys Pro Pro Phe Asp Arg Ser 
    50                  55                  60                  


Ile Ser Gln Asp Ser Leu Asp Glu Leu Ser Met Glu Asp Tyr Trp Ile 
65                  70                  75                  80  


Glu Leu Glu Asn Ile Lys Lys Ser Ser Glu Asn Ser Gln Glu Asp Gln 
                85                  90                  95      


Glu Val Val Val Val Lys Glu Pro Asp Glu Gly Glu Leu Glu Glu Glu 
            100                 105                 110         


Trp Leu Lys Glu Ala Gly Leu Ser Asn Leu Phe Gly Glu Ser Ala Gly 
        115                 120                 125             


Asp Pro Gln Glu Ser Ile Val Phe Leu Ser Thr Leu Thr Arg Thr Gln 
    130                 135                 140                 


Ala Ala Ala Val Gln Lys Arg Val Glu Thr Val Ser Gln Thr Leu Arg 
145                 150                 155                 160 


Lys Lys Asn Lys Gln Tyr Gln Ile Pro Asp Val Arg Asp Ile Phe Ala 
                165                 170                 175     


Gln Gln Arg Glu Ser Lys Glu Thr Ala Pro Gly Gly Thr Glu Ser Gln 
            180                 185                 190         


Ser Leu Arg Thr Asn Glu Asn Lys Tyr Gln Gly Arg Asp Asp Glu Ala 
        195                 200                 205             


Ser Asn Leu Val Gly Glu Glu Lys Leu Ile Pro Pro Glu Glu Thr Pro 
    210                 215                 220                 


Ala Pro Glu Thr Asp Ile Asn Leu Glu Val Ser Phe Ala Glu Gln Ala 
225                 230                 235                 240 


Leu Asn Gln Lys Glu Ser Ser Lys Glu Lys Ile Gln Lys Ser Lys Gly 
                245                 250                 255     


Asp Asp Ala Thr Leu Pro Ser Phe Arg Leu Pro Lys Asp Lys Thr Gly 
            260                 265                 270         


Thr Thr Arg Ile Gly Asp Leu Ala Pro Gln Asp Met Lys Lys Val Cys 
        275                 280                 285             


His Leu Ala Leu Ile Glu Leu Thr Ala Leu Tyr Asp Val Leu Gly Ile 
    290                 295                 300                 


Glu Leu Lys Gln Gln Lys Ala Val Lys Ile Lys Thr Lys Asp Ser Gly 
305                 310                 315                 320 


Leu Phe Cys Val Pro Leu Thr Ala Leu Leu Glu Gln Asp Gln Arg Lys 
                325                 330                 335     


Val Pro Gly Met Arg Ile Pro Leu Ile Phe Gln Lys Leu Ile Ser Arg 
            340                 345                 350         


Ile Glu Glu Arg Gly Leu Glu Thr Glu Gly Leu Leu Arg Ile Pro Gly 
        355                 360                 365             


Ala Ala Ile Arg Ile Lys Asn Leu Cys Gln Glu Leu Glu Ala Lys Phe 
    370                 375                 380                 


Tyr Glu Gly Thr Phe Asn Trp Glu Ser Val Lys Gln His Asp Ala Ala 
385                 390                 395                 400 


Ser Leu Leu Lys Leu Phe Ile Arg Glu Leu Pro Gln Pro Leu Leu Ser 
                405                 410                 415     


Val Glu Tyr Leu Lys Ala Phe Gln Ala Val Gln Asn Leu Pro Thr Lys 
            420                 425                 430         


Lys Gln Gln Leu Gln Ala Leu Asn Leu Leu Val Ile Leu Leu Pro Asp 
        435                 440                 445             


Ala Asn Arg Asp Thr Leu Lys Ala Leu Leu Glu Phe Leu Gln Arg Val 
    450                 455                 460                 


Ile Asp Asn Lys Glu Lys Asn Lys Met Thr Val Met Asn Val Ala Met 
465                 470                 475                 480 


Val Met Ala Pro Asn Leu Phe Met Cys His Ala Leu Gly Leu Lys Ser 
                485                 490                 495     


Ser Glu Gln Arg Glu Phe Val Met Ala Ala Gly Thr Ala Asn Thr Met 
            500                 505                 510         


His Leu Leu Ile Lys Tyr Gln Lys Leu Leu Trp Thr Ile Pro Lys Phe 
        515                 520                 525             


Ile Val Asn Gln Val Arg Lys Gln Asn Thr Glu Asn His Lys Lys Asp 
    530                 535                 540                 


Lys Arg Ala Met Lys Lys Leu Leu Lys Lys Met Ala Tyr Asp Arg Glu 
545                 550                 555                 560 


Lys Tyr Glu Lys Gln Asp Lys Ser Thr Asn Asp Ala Asp Val Pro Gln 
                565                 570                 575     


Gly Val Ile Arg Val Gln Ala Pro His Leu Ser Lys Val Ser Met Ala 
            580                 585                 590         


Ile Gln Leu Thr Glu Glu Leu Lys Ala Ser Asp Val Leu Ala Arg Phe 
        595                 600                 605             


Leu Ser Gln Glu Ser Gly Val Ala Gln Thr Leu Lys Lys Gly Glu Val 
    610                 615                 620                 


Phe Leu Tyr Glu Ile Gly Gly Asn Ile Gly Glu Arg Cys Leu Asp Asp 
625                 630                 635                 640 


Asp Thr Tyr Met Lys Asp Leu Tyr Gln Leu Asn Pro Asn Ala Glu Trp 
                645                 650                 655     


Val Ile Lys Ser Lys Pro Leu 
            660             


<210>  710
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP1__Homo_sapiens__XP_011518397

<400>  710

Met Asp Pro Leu Ser Glu Leu Gln Asp Asp Leu Thr Leu Asp Asp Thr 
1               5                   10                  15      


Ser Glu Ala Leu Asn Gln Leu Lys Leu Ala Ser Ile Asp Glu Lys Asn 
            20                  25                  30          


Trp Pro Ser Asp Glu Met Pro Asp Phe Pro Lys Ser Asp Asp Ser Lys 
        35                  40                  45              


Ser Ser Ser Pro Glu Leu Val Thr His Leu Lys Trp Asp Asp Pro Tyr 
    50                  55                  60                  


Tyr Asp Ile Ala Arg His Gln Ile Val Glu Val Ala Gly Asp Asp Lys 
65                  70                  75                  80  


Tyr Gly Arg Lys Ile Ile Val Phe Ser Ala Cys Arg Met Pro Pro Ser 
                85                  90                  95      


His Gln Leu Asp His Ser Lys Leu Leu Gly Tyr Leu Lys His Thr Leu 
            100                 105                 110         


Asp Gln Tyr Val Glu Ser Asp Tyr Thr Leu Leu Tyr Leu His His Gly 
        115                 120                 125             


Leu Thr Ser Asp Asn Lys Pro Ser Leu Ser Trp Leu Arg Asp Ala Tyr 
    130                 135                 140                 


Arg Glu Phe Asp Arg Lys Tyr Lys Lys Asn Ile Lys Ala Leu Tyr Ile 
145                 150                 155                 160 


Val His Pro Thr Met Phe Ile Lys Thr Leu Leu Ile Leu Phe Lys Pro 
                165                 170                 175     


Leu Ile Ser Phe Lys Phe Gly Gln Lys Ile Phe Tyr Val Asn Tyr Leu 
            180                 185                 190         


Ser Glu Leu Ser Glu His Val Lys Leu Glu Gln Leu Gly Ile Pro Arg 
        195                 200                 205             


Gln Val Leu Lys Tyr Asp Asp Phe Leu Lys Ser Thr Gln Lys Ser Pro 
    210                 215                 220                 


Ala Thr Ala Pro Lys Pro Met Pro Pro Arg Pro Pro Leu Pro Asn Gln 
225                 230                 235                 240 


Gln Phe Gly Val Ser Leu Gln His Leu Gln Glu Lys Asn Pro Glu Gln 
                245                 250                 255     


Glu Pro Ile Pro Ile Val Leu Arg Glu Thr Val Ala Tyr Leu Gln Ala 
            260                 265                 270         


His Ala Leu Thr Thr Glu Gly Ile Phe Arg Arg Ser Ala Asn Thr Gln 
        275                 280                 285             


Val Val Arg Glu Val Gln Gln Lys Tyr Asn Met Gly Leu Pro Val Asp 
    290                 295                 300                 


Phe Asp Gln Tyr Asn Glu Leu His Leu Pro Ala Val Ile Leu Lys Thr 
305                 310                 315                 320 


Phe Leu Arg Glu Leu Pro Glu Pro Leu Leu Thr Phe Asp Leu Tyr Pro 
                325                 330                 335     


His Val Val Gly Phe Leu Asn Ile Asp Glu Ser Gln Arg Val Pro Ala 
            340                 345                 350         


Thr Leu Gln Val Leu Gln Thr Leu Pro Glu Glu Asn Tyr Gln Val Leu 
        355                 360                 365             


Arg Phe Leu Thr Ala Phe Leu Val Gln Ile Ser Ala His Ser Asp Gln 
    370                 375                 380                 


Asn Lys Met Thr Asn Thr Asn Leu Ala Val Val Phe Gly Pro Asn Leu 
385                 390                 395                 400 


Leu Trp Ala Lys Asp Ala Ala Ile Thr Leu Lys Ala Ile Asn Pro Ile 
                405                 410                 415     


Asn Thr Phe Thr Lys Phe Leu Leu Asp His Gln Gly Glu Leu Phe Pro 
            420                 425                 430         


Ser Pro Asp Pro Ser Gly Leu 
        435                 


<210>  711
<211>  1168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP20__Homo_sapiens__NP_001245344

<400>  711

Met Ser Ala Arg Glu Arg Gln Pro Ala Leu Lys Lys Lys Met Lys Thr 
1               5                   10                  15      


Leu Ala Glu Arg Arg Arg Ser Ala Pro Ser Leu Ile Leu Asp Lys Ala 
            20                  25                  30          


Leu Gln Lys Arg Pro Thr Thr Arg Asp Ser Pro Ser Ala Ser Val Asp 
        35                  40                  45              


Thr Cys Thr Phe Leu Ser Ser Leu Val Cys Ser Asn Arg Thr Leu Leu 
    50                  55                  60                  


Ile Asp Gly Arg Ala Glu Leu Lys Arg Gly Leu Gln Arg Gln Glu Arg 
65                  70                  75                  80  


His Leu Phe Leu Phe Asn Asp Leu Phe Val Val Ala Lys Ile Lys Tyr 
                85                  90                  95      


Asn Asn Asn Phe Lys Ile Lys Asn Lys Ile Lys Leu Thr Asp Met Trp 
            100                 105                 110         


Thr Ala Ser Cys Val Asp Glu Val Gly Glu Gly Asn Thr Asn Ala Met 
        115                 120                 125             


Lys Ser Phe Val Leu Gly Trp Pro Thr Val Asn Phe Val Ala Thr Phe 
    130                 135                 140                 


Ser Ser Pro Glu Gln Lys Asp Lys Trp Leu Ser Leu Leu Gln Arg Tyr 
145                 150                 155                 160 


Ile Asn Leu Glu Lys Glu Lys Asp Tyr Pro Lys Ser Ile Pro Leu Lys 
                165                 170                 175     


Ile Phe Ala Lys Asp Ile Gly Asn Cys Ala Tyr Ser Lys Thr Ile Thr 
            180                 185                 190         


Val Met Asn Ser Asp Thr Ala Asn Glu Val Ile Asn Met Ser Leu Pro 
        195                 200                 205             


Met Leu Gly Ile Thr Gly Ser Glu Arg Asp Tyr Gln Leu Trp Val Asn 
    210                 215                 220                 


Ser Gly Lys Glu Glu Ala Pro Tyr Pro Leu Ile Gly His Glu Tyr Pro 
225                 230                 235                 240 


Tyr Gly Ile Lys Met Ser His Leu Arg Asp Ser Ala Leu Leu Thr Pro 
                245                 250                 255     


Gly Ser Lys Asp Ser Thr Thr Pro Phe Asn Leu Gln Glu Pro Phe Leu 
            260                 265                 270         


Met Glu Gln Leu Pro Arg Glu Met Gln Cys Gln Phe Ile Leu Lys Pro 
        275                 280                 285             


Ser Arg Leu Ala Ala Ala Gln Gln Leu Ser Asp Ser Gly His Lys Thr 
    290                 295                 300                 


Phe Lys Arg Arg Arg Ser Ile Ile Asn Trp Ala Phe Trp Arg Gly Ser 
305                 310                 315                 320 


Ser Thr His Leu Asp Asn Leu Pro Ser Ser Pro Thr Ser Pro Met Pro 
                325                 330                 335     


Gly Gln Leu Phe Gly Ile Ser Leu Pro Asn Ile Cys Glu Asn Asp Asn 
            340                 345                 350         


Leu Pro Lys Pro Val Leu Asp Met Leu Phe Phe Leu Asn Gln Lys Gly 
        355                 360                 365             


Pro Leu Thr Lys Gly Ile Phe Arg Gln Ser Ala Asn Val Lys Ser Cys 
    370                 375                 380                 


Arg Glu Leu Lys Glu Lys Leu Asn Ser Gly Val Glu Val His Leu Asp 
385                 390                 395                 400 


Cys Glu Ser Ile Phe Val Ile Ala Ser Val Leu Lys Asp Phe Leu Arg 
                405                 410                 415     


Asn Ile Pro Gly Ser Ile Phe Ser Ser Asp Leu Tyr Asp His Trp Val 
            420                 425                 430         


Ser Val Met Asp Gln Gly Asn Asp Glu Glu Lys Ile Asn Thr Val Gln 
        435                 440                 445             


Arg Leu Leu Asp Gln Leu Pro Arg Ala Asn Val Val Leu Leu Arg Tyr 
    450                 455                 460                 


Leu Phe Gly Val Leu His Asn Ile Glu Gln His Ser Ser Ser Asn Gln 
465                 470                 475                 480 


Met Thr Ala Phe Asn Leu Ala Val Cys Val Ala Pro Ser Ile Leu Trp 
                485                 490                 495     


Pro Pro Ala Ser Ser Ser Pro Glu Leu Glu Asn Glu Phe Thr Lys Lys 
            500                 505                 510         


Val Ser Leu Leu Ile Gln Phe Leu Ile Glu Asn Cys Leu Arg Ile Phe 
        515                 520                 525             


Gly Glu Glu Ile Thr Ser Leu Phe Arg Glu Val Ser Val Arg Cys Asp 
    530                 535                 540                 


Thr Arg Glu Asn Ala Ser Asp Ile Ser Cys Phe Gln Leu Asn Asp Ser 
545                 550                 555                 560 


Ser Tyr Asp Ser Leu Glu Asn Glu Leu Asn Glu Asp Val Asp Ala Pro 
                565                 570                 575     


Cys Ser Asp Leu Val Lys Lys Leu Gly Gln Gly Ser Arg Ser Met Asp 
            580                 585                 590         


Ser Val Leu Thr Leu Ser Asp Tyr Asp Leu Asp Gln Pro Glu Val Glu 
        595                 600                 605             


Gly Leu Leu Thr Leu Ser Asp Phe Asp Leu Ala His Ser Lys Asp Glu 
    610                 615                 620                 


Asp Val Gln Met Lys Arg Pro Leu Glu Ser Lys Pro Val Asn Ile Leu 
625                 630                 635                 640 


Val Tyr Thr Lys Ile Pro Leu Arg Asp His Ala Arg Ala Pro Ser Ala 
                645                 650                 655     


Met Cys Thr Pro Ser Tyr Leu Ser Thr Ala Ala Ala Asn Ala Ala Lys 
            660                 665                 670         


Ser Leu Arg Arg His Arg Arg Cys Ser Glu Pro Ser Ile Asp Tyr Leu 
        675                 680                 685             


Asp Ser Lys Leu Ser Tyr Leu Arg Glu Phe Tyr Gln Lys Lys Leu Arg 
    690                 695                 700                 


Lys Ser Ser Cys Asp Ala Ile Leu Ser Gln Lys Asp Glu Asp Tyr Leu 
705                 710                 715                 720 


Lys Gln Asn Gln Pro Leu Gln Glu Glu Gly Lys Thr Cys Phe Lys Gln 
                725                 730                 735     


Ser Leu Val Thr Gly Thr Asp Val Ser Lys Lys Asn Ala Thr Thr Gln 
            740                 745                 750         


Asn Thr Lys Lys Lys Ser Leu Ser Gly Ser Glu Gly Asn His Val Lys 
        755                 760                 765             


Leu Phe Pro Lys Ser Lys Pro Val Ala Ile Ser Val Ala Ser Tyr Ser 
    770                 775                 780                 


Pro Met Ser Ser Gln Asp His Ser Lys Asn Gln Pro Phe Asp Val Asn 
785                 790                 795                 800 


Thr Ser Gly Tyr Ser Pro Pro His Thr Ala Asp Ala Leu Lys Gly Pro 
                805                 810                 815     


Arg Thr His Arg Arg Cys Ser Glu Pro Asn Ile Glu Asp Gln Asn Arg 
            820                 825                 830         


Lys Leu Thr Tyr Leu Arg Gly Ile Tyr Ser Lys Lys Gln His Lys Thr 
        835                 840                 845             


Ser Cys Glu Ala Gly Leu Leu His Gly Glu Glu Asp Tyr Leu Lys Arg 
    850                 855                 860                 


His Lys Ser Leu Gln Met Glu Gly Gln Lys Leu Ile Asn Gln Ser Leu 
865                 870                 875                 880 


Val Met Gly Ile Glu Val Gly Lys Ser Ser Ala Thr Asn Gln Asn Thr 
                885                 890                 895     


Glu Lys Val Leu Pro Pro Arg Leu Asn Leu Cys Pro Arg Thr Ser Tyr 
            900                 905                 910         


Ser Ser Leu Ser Ser Pro Gly Thr Ser Pro Ser Gly Ser Ser Val Ser 
        915                 920                 925             


Ser Gln Asp Ser Ala Phe Ser Gln Ile Ser Glu His Ser Val Phe Thr 
    930                 935                 940                 


Pro Thr Glu Thr Ser Ser Pro Ile Asp Cys Thr Phe Gln Ala Gln Arg 
945                 950                 955                 960 


Lys Arg Glu Asp Leu Ser Pro Asp Phe Ser Asn Ala Ser His Val Ser 
                965                 970                 975     


Gly Met Pro Gly Pro Ser Ser Gly Gln Ala Cys Ser Arg Pro Ala Tyr 
            980                 985                 990         


Thr Lys Lys Asp Thr Met Glu Trp  His Ser Gln Met His  Ser Val Thr 
        995                 1000                 1005             


Leu His  Pro Ser Thr Trp Leu  Arg Asn Gly Val Ala  Ser Leu Lys 
    1010                 1015                 1020             


Asn Trp  Ser Leu Lys Lys Lys  Ala Lys Ala Ala Arg  Pro Glu Glu 
    1025                 1030                 1035             


Glu Lys  Ile Ala Ser Pro Lys  Gly Pro Leu Glu Pro  Pro Pro His 
    1040                 1045                 1050             


Ala Ser  Gly Val Pro Glu Ala  Asn Ser Leu Gln Glu  Glu Gln Lys 
    1055                 1060                 1065             


Asp Leu  Pro Leu Arg Ala Ala  Glu Gly Leu Ser Pro  Val Gln Ser 
    1070                 1075                 1080             


Ala Gln  Arg Cys Ser Ser Ser  Pro Phe Gln Asp Ser  Glu Arg His 
    1085                 1090                 1095             


Cys Ser  Ser Pro Phe Ser Leu  Val Glu Ser Arg Leu  Lys Leu Cys 
    1100                 1105                 1110             


Met Lys  Ser His Glu Glu Ile  Glu Pro Gly Ser Gln  Ser Ser Ser 
    1115                 1120                 1125             


Gly Ser  Leu Pro Trp Glu Arg  Ala Ser Ala Ser Ser  Trp Thr Leu 
    1130                 1135                 1140             


Glu Asp  Ala Thr Ser Pro Asp  Ser Gly Pro Thr Val  Val Cys Asp 
    1145                 1150                 1155             


Ile Glu  Asp Arg Tyr Leu Thr  Lys Asp Ile 
    1160                 1165             


<210>  712
<211>  1958
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP21__Homo_sapiens__XP_005252599

<400>  712

Met Met Ala Thr Arg Arg Thr Gly Leu Ser Glu Gly Asp Gly Asp Lys 
1               5                   10                  15      


Leu Lys Ala Cys Glu Val Ser Lys Asn Lys Asp Gly Lys Glu Gln Ser 
            20                  25                  30          


Glu Thr Val Ser Leu Ser Glu Asp Glu Thr Phe Ser Trp Pro Gly Pro 
        35                  40                  45              


Lys Thr Val Thr Leu Lys Arg Thr Ser Gln Gly Phe Gly Phe Thr Leu 
    50                  55                  60                  


Arg His Phe Ile Val Tyr Pro Pro Glu Ser Ala Ile Gln Phe Ser Tyr 
65                  70                  75                  80  


Lys Asp Glu Glu Asn Gly Asn Arg Gly Gly Lys Gln Arg Asn Arg Leu 
                85                  90                  95      


Glu Pro Met Asp Thr Ile Phe Val Lys Gln Val Lys Glu Gly Gly Pro 
            100                 105                 110         


Ala Phe Glu Ala Gly Leu Cys Thr Gly Asp Arg Ile Ile Lys Val Asn 
        115                 120                 125             


Gly Glu Ser Val Ile Gly Lys Thr Tyr Ser Gln Val Ile Ala Leu Ile 
    130                 135                 140                 


Gln Asn Ser Asp Thr Thr Leu Glu Leu Ser Val Met Pro Lys Asp Glu 
145                 150                 155                 160 


Asp Ile Leu Gln Val Leu Gln Phe Thr Lys Asp Val Thr Ala Leu Ala 
                165                 170                 175     


Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Ala Tyr Ser Gly Asn 
            180                 185                 190         


Ala Arg Asn Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Trp Leu Pro 
        195                 200                 205             


Ser Ala Pro Ser Ala Met Ala Gln Pro Val Glu Ile Ser Pro Pro Asp 
    210                 215                 220                 


Ser Ser Leu Ser Lys Gln Gln Thr Ser Thr Pro Val Leu Thr Gln Pro 
225                 230                 235                 240 


Gly Arg Ala Tyr Arg Met Glu Ile Gln Val Pro Pro Ser Pro Thr Asp 
                245                 250                 255     


Val Ala Lys Ser Asn Thr Ala Val Cys Val Cys Asn Glu Ser Val Arg 
            260                 265                 270         


Thr Val Ile Val Pro Ser Glu Lys Val Val Asp Leu Leu Ser Asn Arg 
        275                 280                 285             


Asn Asn His Thr Gly Pro Ser His Arg Thr Glu Glu Val Arg Tyr Gly 
    290                 295                 300                 


Val Ser Glu Gln Thr Ser Leu Lys Thr Val Ser Arg Thr Thr Ser Pro 
305                 310                 315                 320 


Pro Leu Ser Ile Pro Thr Thr His Leu Ile His Gln Pro Ala Gly Ser 
                325                 330                 335     


Arg Ser Leu Glu Pro Ser Gly Ile Leu Leu Lys Ser Gly Asn Tyr Ser 
            340                 345                 350         


Gly His Ser Asp Gly Ile Ser Ser Ser Arg Ser Gln Ala Val Glu Ala 
        355                 360                 365             


Pro Ser Val Ser Val Asn His Tyr Ser Pro Asn Ser His Gln His Ile 
    370                 375                 380                 


Asp Trp Lys Asn Tyr Lys Thr Tyr Lys Glu Tyr Ile Asp Asn Arg Arg 
385                 390                 395                 400 


Leu His Ile Gly Cys Arg Thr Ile Gln Glu Arg Leu Asp Ser Leu Arg 
                405                 410                 415     


Ala Ala Ser Gln Ser Thr Thr Asp Tyr Asn Gln Val Val Pro Asn Arg 
            420                 425                 430         


Thr Thr Leu Gln Gly Arg Arg Arg Ser Thr Ser His Asp Arg Val Pro 
        435                 440                 445             


Gln Ser Val Gln Ile Arg Gln Arg Ser Val Ser Gln Glu Arg Leu Glu 
    450                 455                 460                 


Asp Ser Val Leu Met Lys Tyr Cys Pro Arg Ser Ala Ser Gln Gly Ala 
465                 470                 475                 480 


Leu Thr Ser Pro Ser Val Ser Phe Ser Asn His Arg Thr Arg Ser Trp 
                485                 490                 495     


Asp Tyr Ile Glu Gly Gln Asp Glu Thr Leu Glu Asn Val Asn Ser Gly 
            500                 505                 510         


Thr Pro Ile Pro Asp Ser Asn Gly Glu Lys Lys Gln Thr Tyr Lys Trp 
        515                 520                 525             


Ser Gly Phe Thr Glu Gln Asp Asp Arg Arg Gly Ile Cys Glu Arg Pro 
    530                 535                 540                 


Arg Gln Gln Glu Ile His Lys Ser Phe Arg Gly Ser Asn Phe Thr Val 
545                 550                 555                 560 


Ala Pro Ser Val Val Asn Ser Asp Asn Arg Arg Met Ser Gly Arg Gly 
                565                 570                 575     


Val Gly Ser Val Ser Gln Phe Lys Lys Ile Pro Pro Asp Leu Lys Thr 
            580                 585                 590         


Leu Gln Ser Asn Arg Asn Phe Gln Thr Thr Cys Gly Met Ser Leu Pro 
        595                 600                 605             


Arg Gly Ile Ser Gln Asp Arg Ser Pro Leu Val Lys Val Arg Ser Asn 
    610                 615                 620                 


Ser Leu Lys Ala Pro Ser Thr His Val Thr Lys Pro Ser Phe Ser Gln 
625                 630                 635                 640 


Lys Ser Phe Val Ser Ile Lys Asp Gln Arg Pro Val Asn His Leu His 
                645                 650                 655     


Gln Asn Ser Leu Leu Asn Gln Gln Thr Trp Val Arg Thr Asp Ser Ala 
            660                 665                 670         


Pro Asp Gln Gln Val Glu Thr Gly Lys Ser Pro Ser Leu Ser Gly Ala 
        675                 680                 685             


Ser Ala Lys Pro Ala Pro Gln Ser Ser Glu Asn Ala Gly Thr Ser Asp 
    690                 695                 700                 


Leu Glu Leu Pro Val Ser Gln Arg Asn Gln Asp Leu Ser Leu Gln Glu 
705                 710                 715                 720 


Ala Glu Thr Glu Gln Ser Asp Thr Leu Asp Asn Lys Glu Ala Val Ile 
                725                 730                 735     


Leu Arg Glu Lys Pro Pro Ser Gly Arg Gln Thr Pro Gln Pro Leu Arg 
            740                 745                 750         


His Gln Ser Tyr Ile Leu Ala Val Asn Asp Gln Glu Thr Gly Ser Asp 
        755                 760                 765             


Thr Thr Cys Trp Leu Pro Asn Asp Ala Arg Arg Glu Val His Ile Lys 
    770                 775                 780                 


Arg Met Glu Glu Arg Lys Ala Ser Ser Thr Ser Pro Pro Gly Asp Ser 
785                 790                 795                 800 


Leu Ala Ser Ile Pro Phe Ile Asp Glu Pro Thr Ser Pro Ser Ile Asp 
                805                 810                 815     


His Asp Ile Ala His Ile Pro Ala Ser Ala Val Ile Ser Ala Ser Thr 
            820                 825                 830         


Ser Gln Val Pro Ser Ile Ala Thr Val Pro Pro Cys Leu Thr Thr Ser 
        835                 840                 845             


Ala Pro Leu Ile Arg Arg Gln Leu Ser His Asp His Glu Ser Val Gly 
    850                 855                 860                 


Pro Pro Ser Leu Asp Ala Gln Pro Asn Ser Lys Thr Glu Arg Ser Lys 
865                 870                 875                 880 


Ser Tyr Asp Glu Gly Leu Asp Asp Tyr Arg Glu Asp Ala Lys Leu Ser 
                885                 890                 895     


Phe Lys His Val Ser Ser Leu Lys Gly Ile Lys Ile Ala Asp Ser Gln 
            900                 905                 910         


Lys Ser Ser Glu Asp Ser Gly Ser Arg Lys Asp Ser Ser Ser Glu Val 
        915                 920                 925             


Phe Ser Asp Ala Ala Lys Glu Gly Trp Leu His Phe Arg Pro Leu Val 
    930                 935                 940                 


Thr Asp Lys Gly Lys Arg Val Gly Gly Ser Ile Arg Pro Trp Lys Gln 
945                 950                 955                 960 


Met Tyr Val Val Leu Arg Gly His Ser Leu Tyr Leu Tyr Lys Asp Lys 
                965                 970                 975     


Arg Glu Gln Thr Thr Pro Ser Glu Glu Glu Gln Pro Ile Ser Val Asn 
            980                 985                 990         


Ala Cys Leu Ile Asp Ile Ser Tyr  Ser Glu Thr Lys Arg  Lys Asn Val 
        995                 1000                 1005             


Phe Arg  Leu Thr Thr Ser Asp  Cys Glu Cys Leu Phe  Gln Ala Glu 
    1010                 1015                 1020             


Asp Arg  Asp Asp Met Leu Ala  Trp Ile Lys Thr Ile  Gln Glu Ser 
    1025                 1030                 1035             


Ser Asn  Leu Asn Glu Glu Asp  Thr Gly Val Thr Asn  Arg Asp Leu 
    1040                 1045                 1050             


Ile Ser  Arg Arg Ile Lys Glu  Tyr Asn Asn Leu Met  Ser Lys Ala 
    1055                 1060                 1065             


Glu Gln  Leu Pro Lys Thr Pro  Arg Gln Ser Leu Ser  Ile Arg Gln 
    1070                 1075                 1080             


Thr Leu  Leu Gly Ala Lys Ser  Glu Pro Lys Thr Gln  Ser Pro His 
    1085                 1090                 1095             


Ser Pro  Lys Glu Glu Ser Glu  Arg Lys Leu Leu Ser  Lys Asp Asp 
    1100                 1105                 1110             


Thr Ser  Pro Pro Lys Asp Lys  Gly Thr Trp Arg Lys  Gly Ile Pro 
    1115                 1120                 1125             


Ser Ile  Met Arg Lys Thr Phe  Glu Lys Lys Pro Thr  Ala Thr Gly 
    1130                 1135                 1140             


Thr Phe  Gly Val Arg Leu Asp  Asp Cys Pro Pro Ala  His Thr Asn 
    1145                 1150                 1155             


Arg Tyr  Ile Pro Leu Ile Val  Asp Ile Cys Cys Lys  Leu Val Glu 
    1160                 1165                 1170             


Glu Arg  Gly Leu Glu Tyr Thr  Gly Ile Tyr Arg Val  Pro Gly Asn 
    1175                 1180                 1185             


Asn Ala  Ala Ile Ser Ser Met  Gln Glu Glu Leu Asn  Lys Gly Met 
    1190                 1195                 1200             


Ala Asp  Ile Asp Ile Gln Asp  Asp Lys Trp Arg Asp  Leu Asn Val 
    1205                 1210                 1215             


Ile Ser  Ser Leu Leu Lys Ser  Phe Phe Arg Lys Leu  Pro Glu Pro 
    1220                 1225                 1230             


Leu Phe  Thr Asn Asp Lys Tyr  Ala Asp Phe Ile Glu  Ala Asn Arg 
    1235                 1240                 1245             


Lys Glu  Asp Pro Leu Asp Arg  Leu Lys Thr Leu Lys  Arg Leu Ile 
    1250                 1255                 1260             


His Asp  Leu Pro Glu His His  Tyr Glu Thr Leu Lys  Phe Leu Ser 
    1265                 1270                 1275             


Ala His  Leu Lys Thr Val Ala  Glu Asn Ser Glu Lys  Asn Lys Met 
    1280                 1285                 1290             


Glu Pro  Arg Asn Leu Ala Ile  Val Phe Gly Pro Thr  Leu Val Arg 
    1295                 1300                 1305             


Thr Ser  Glu Asp Asn Met Thr  His Met Val Thr His  Met Pro Asp 
    1310                 1315                 1320             


Gln Tyr  Lys Ile Val Glu Thr  Leu Ile Gln His His  Asp Trp Phe 
    1325                 1330                 1335             


Phe Thr  Glu Glu Gly Ala Glu  Glu Pro Leu Thr Thr  Val Gln Glu 
    1340                 1345                 1350             


Glu Ser  Thr Val Asp Ser Gln  Pro Val Pro Asn Ile  Asp His Leu 
    1355                 1360                 1365             


Leu Thr  Asn Ile Gly Arg Thr  Gly Val Ser Pro Gly  Asp Val Ser 
    1370                 1375                 1380             


Asp Ser  Ala Thr Ser Asp Ser  Thr Lys Ser Lys Gly  Ser Trp Gly 
    1385                 1390                 1395             


Ser Gly  Lys Asp Gln Tyr Ser  Arg Glu Leu Leu Val  Ser Ser Ile 
    1400                 1405                 1410             


Phe Ala  Ala Ala Ser Arg Lys  Arg Lys Lys Pro Lys  Glu Lys Ala 
    1415                 1420                 1425             


Gln Pro  Ser Ser Ser Glu Asp  Glu Leu Asp Asn Val  Phe Phe Lys 
    1430                 1435                 1440             


Lys Glu  Asn Val Glu Gln Cys  His Asn Asp Thr Lys  Glu Glu Ser 
    1445                 1450                 1455             


Lys Lys  Glu Ser Glu Thr Leu  Gly Arg Lys Gln Lys  Ile Ile Ile 
    1460                 1465                 1470             


Ala Lys  Glu Asn Ser Thr Arg  Lys Asp Pro Ser Thr  Thr Lys Asp 
    1475                 1480                 1485             


Glu Lys  Ile Ser Leu Gly Lys  Glu Ser Thr Pro Ser  Glu Glu Pro 
    1490                 1495                 1500             


Ser Pro  Pro His Asn Ser Lys  His Asn Lys Ser Pro  Thr Leu Ser 
    1505                 1510                 1515             


Cys Arg  Phe Ala Ile Leu Lys  Glu Ser Pro Arg Ser  Leu Leu Ala 
    1520                 1525                 1530             


Gln Lys  Ser Ser His Leu Glu  Glu Thr Gly Ser Asp  Ser Gly Thr 
    1535                 1540                 1545             


Leu Leu  Ser Thr Ser Ser Gln  Ala Ser Leu Ala Arg  Phe Ser Met 
    1550                 1555                 1560             


Lys Lys  Ser Thr Ser Pro Glu  Thr Lys His Ser Glu  Phe Leu Ala 
    1565                 1570                 1575             


Asn Val  Ser Thr Ile Thr Ser  Asp Tyr Ser Thr Thr  Ser Ser Ala 
    1580                 1585                 1590             


Thr Tyr  Leu Thr Ser Leu Asp  Ser Ser Arg Leu Ser  Pro Glu Val 
    1595                 1600                 1605             


Gln Ser  Val Ala Glu Ser Lys  Gly Asp Glu Ala Asp  Asp Glu Arg 
    1610                 1615                 1620             


Ser Glu  Leu Ile Ser Glu Gly  Arg Pro Val Glu Thr  Asp Ser Glu 
    1625                 1630                 1635             


Ser Glu  Phe Pro Val Phe Pro  Thr Ala Leu Thr Ser  Glu Arg Leu 
    1640                 1645                 1650             


Phe Arg  Gly Lys Leu Gln Glu  Val Thr Lys Ser Ser  Arg Arg Asn 
    1655                 1660                 1665             


Ser Glu  Gly Ser Glu Leu Ser  Cys Thr Glu Gly Ser  Leu Thr Ser 
    1670                 1675                 1680             


Ser Leu  Asp Ser Arg Arg Gln  Leu Phe Ser Ser His  Lys Leu Ile 
    1685                 1690                 1695             


Glu Cys  Asp Thr Leu Ser Arg  Lys Lys Ser Ala Arg  Phe Lys Ser 
    1700                 1705                 1710             


Asp Ser  Gly Ser Leu Gly Asp  Ala Lys Asn Glu Lys  Glu Ala Pro 
    1715                 1720                 1725             


Ser Leu  Thr Lys Val Phe Asp  Val Met Lys Lys Gly  Lys Ser Thr 
    1730                 1735                 1740             


Gly Ser  Leu Leu Thr Pro Thr  Arg Gly Glu Ser Glu  Lys Gln Glu 
    1745                 1750                 1755             


Pro Thr  Trp Lys Thr Lys Ile  Ala Asp Arg Leu Lys  Leu Arg Pro 
    1760                 1765                 1770             


Arg Ala  Pro Ala Asp Asp Met  Phe Gly Val Gly Asn  His Lys Val 
    1775                 1780                 1785             


Asn Ala  Glu Thr Ala Lys Arg  Lys Ser Ile Arg Arg  Arg His Thr 
    1790                 1795                 1800             


Leu Gly  Gly His Arg Asp Ala  Thr Glu Ile Ser Val  Leu Asn Phe 
    1805                 1810                 1815             


Trp Lys  Val His Glu Gln Ser  Gly Glu Arg Glu Ser  Glu Leu Ser 
    1820                 1825                 1830             


Ala Val  Asn Arg Leu Lys Pro  Lys Cys Ser Ala Gln  Asp Leu Ser 
    1835                 1840                 1845             


Ile Ser  Asp Trp Leu Ala Arg  Glu Arg Leu Arg Thr  Ser Thr Ser 
    1850                 1855                 1860             


Asp Leu  Ser Arg Gly Glu Ile  Gly Asp Pro Gln Thr  Glu Asn Pro 
    1865                 1870                 1875             


Ser Thr  Arg Glu Ile Ala Thr  Thr Asp Thr Pro Leu  Ser Leu His 
    1880                 1885                 1890             


Cys Asn  Thr Gly Ser Ser Ser  Ser Thr Leu Ala Ser  Thr Asn Arg 
    1895                 1900                 1905             


Pro Leu  Leu Ser Ile Pro Pro  Gln Ser Pro Asp Gln  Ile Asn Gly 
    1910                 1915                 1920             


Glu Ser  Phe Gln Asn Val Ser  Lys Asn Ala Ser Ser  Ala Ala Asn 
    1925                 1930                 1935             


Ala Gln  Pro His Lys Leu Ser  Glu Thr Pro Gly Ser  Lys Ala Glu 
    1940                 1945                 1950             


Phe His  Pro Cys Leu 
    1955             


<210>  713
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP22__Homo_sapiens__NP_001242953

<400>  713

Met Leu Ser Pro Lys Ile Arg Gln Ala Arg Arg Ala Arg Ser Lys Ser 
1               5                   10                  15      


Leu Val Met Gly Glu Gln Ser Arg Ser Pro Gly Arg Met Pro Cys Pro 
            20                  25                  30          


His Arg Leu Gly Pro Val Leu Lys Ala Gly Trp Leu Lys Lys Gln Arg 
        35                  40                  45              


Ser Ile Met Lys Asn Trp Gln Gln Arg Trp Phe Val Leu Arg Gly Asp 
    50                  55                  60                  


Gln Leu Phe Tyr Tyr Lys Asp Lys Asp Glu Ile Lys Pro Gln Gly Phe 
65                  70                  75                  80  


Ile Ser Leu Gln Gly Thr Gln Val Thr Glu Leu Pro Pro Gly Pro Glu 
                85                  90                  95      


Asp Pro Gly Lys His Leu Phe Glu Ile Ser Pro Gly Gly Ala Gly Glu 
            100                 105                 110         


Arg Glu Lys Val Pro Ala Asn Pro Glu Ala Leu Leu Leu Met Ala Ser 
        115                 120                 125             


Ser Gln Arg Asp Met Glu Asp Trp Val Gln Ala Ile Arg Arg Val Ile 
    130                 135                 140                 


Trp Ala Pro Leu Gly Gly Gly Thr Ala Arg Arg Ser His Ala His Pro 
145                 150                 155                 160 


Leu Glu Pro Leu Pro Pro Gly Ile Phe Gly Gln Arg Leu Glu Glu Thr 
                165                 170                 175     


Val His His Glu Arg Lys Tyr Gly Pro Arg Leu Ala Pro Leu Leu Val 
            180                 185                 190         


Glu Gln Cys Val Asp Phe Ile Arg Glu Arg Gly Leu Thr Glu Glu Gly 
        195                 200                 205             


Leu Phe Arg Met Pro Gly Gln Ala Asn Leu Val Arg Asp Leu Gln Asp 
    210                 215                 220                 


Ser Phe Asp Cys Gly Glu Lys Pro Leu Phe Asp Ser Thr Thr Asp Val 
225                 230                 235                 240 


His Thr Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu 
                245                 250                 255     


Pro Val Val Pro Phe Ala Arg Tyr Glu Asp Phe Leu Ser Cys Ala Gln 
            260                 265                 270         


Leu Leu Thr Lys Asp Glu Gly Glu Gly Thr Leu Glu Leu Ala Lys Gln 
        275                 280                 285             


Val Ser Asn Leu Pro Gln Ala Asn Tyr Asn Leu Leu Arg Tyr Ile Cys 
    290                 295                 300                 


Lys Phe Leu Asp Glu Val Gln Ala Tyr Ser Asn Val Asn Lys Met Ser 
305                 310                 315                 320 


Val Gln Asn Leu Ala Thr Val Phe Gly Pro Asn Ile Leu Arg Pro Gln 
                325                 330                 335     


Val Glu Asp Pro Val Thr Ile Met Glu Gly Thr Ser Leu Val Gln His 
            340                 345                 350         


Leu Met Thr Val Leu Ile Arg Lys His Ser Gln Leu Phe Thr Ala Pro 
        355                 360                 365             


Val Pro Glu Gly Pro Thr Ser Pro Arg Gly Gly Leu Gln Cys Ala Val 
    370                 375                 380                 


Gly Trp Gly Ser Glu Glu Val Thr Arg Asp Ser Gln Gly Glu Pro Gly 
385                 390                 395                 400 


Gly Pro Gly Leu Pro Ala His Arg Thr Ser Ser Leu Asp Gly Ala Ala 
                405                 410                 415     


Val Ala Val Leu Ser Arg Thr Ala Pro Thr Gly Pro Gly Ser Arg Cys 
            420                 425                 430         


Ser Pro Gly Lys Lys Val Gln Thr Leu Pro Ser Trp Lys Ser Ser Phe 
        435                 440                 445             


Arg Gln Pro Arg Ser Leu Ser Gly Ser Pro Lys Gly Gly Gly Ser Ser 
    450                 455                 460                 


Leu Glu Val Pro Ile Ile Ser Ser Gly Gly Asn Trp Leu Met Asn Gly 
465                 470                 475                 480 


Leu Ser Ser Leu Arg Gly His Arg Arg Ala Ser Ser Gly Asp Arg Leu 
                485                 490                 495     


Lys Asp Ser Gly Ser Val Gln Arg Leu Ser Thr Tyr Asp Asn Val Pro 
            500                 505                 510         


Ala Pro Gly Leu Val Pro Gly Ile Pro Ser Val Ala Ser Met Ala Trp 
        515                 520                 525             


Ser Gly Ala Ser Ser Ser Glu Ser Ser Val Gly Gly Ser Leu Ser Ser 
    530                 535                 540                 


Cys Thr Ala Cys Arg Ala Ser Asp Ser Ser Ala Arg Ser Ser Leu His 
545                 550                 555                 560 


Thr Asp Trp Ala Leu Glu Pro Ser Pro Leu Pro Ser Ser Ser Glu Asp 
                565                 570                 575     


Pro Lys Ser Leu Asp Leu Asp His Ser Met Asp Glu Ala Gly Ala Gly 
            580                 585                 590         


Ala Ser Asn Ser Glu Pro Ser Glu Pro Asp Ser Pro Thr Arg Glu His 
        595                 600                 605             


Ala Arg Arg Ser Glu Ala Leu Gln Gly Leu Val Thr Glu Leu Arg Ala 
    610                 615                 620                 


Glu Leu Cys Arg Gln Arg Thr Glu Tyr Glu Arg Ser Val Lys Arg Ile 
625                 630                 635                 640 


Glu Glu Gly Ser Ala Asp Leu Arg Lys Arg Met Ser Arg Leu Glu Glu 
                645                 650                 655     


Glu Leu Asp Gln Glu Lys Lys Lys Tyr Ile Met Leu Glu Ile Lys Leu 
            660                 665                 670         


Arg Asn Ser Glu Arg Ala Arg Glu Asp Ala Glu Arg Arg Asn Gln Leu 
        675                 680                 685             


Leu Gln Arg Glu Met Glu Glu Phe Phe Ser Thr Leu Gly Ser Leu Thr 
    690                 695                 700                 


Val Gly Ala Lys Gly Ala Arg Ala Pro Lys 
705                 710                 


<210>  714
<211>  1491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP23__Homo_sapiens__NP_001186346

<400>  714

Met Asn Gly Val Ala Phe Cys Leu Val Gly Ile Pro Pro Arg Pro Glu 
1               5                   10                  15      


Pro Arg Pro Pro Gln Leu Pro Leu Gly Pro Arg Asp Gly Cys Ser Pro 
            20                  25                  30          


Arg Arg Pro Phe Pro Trp Gln Gly Pro Arg Thr Leu Leu Leu Tyr Lys 
        35                  40                  45              


Ser Pro Gln Asp Gly Phe Gly Phe Thr Leu Arg His Phe Ile Val Tyr 
    50                  55                  60                  


Pro Pro Glu Ser Ala Val His Cys Ser Leu Lys Glu Glu Glu Asn Gly 
65                  70                  75                  80  


Gly Arg Gly Gly Gly Pro Ser Pro Arg Tyr Arg Leu Glu Pro Met Asp 
                85                  90                  95      


Thr Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His Arg Ala 
            100                 105                 110         


Gly Leu Arg Thr Gly Asp Arg Leu Val Lys Val Asn Gly Glu Ser Val 
        115                 120                 125             


Ile Gly Lys Thr Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn Ser Asp 
    130                 135                 140                 


Asp Thr Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile Leu Gln 
145                 150                 155                 160 


Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro Tyr Ser 
                165                 170                 175     


Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Arg 
            180                 185                 190         


Lys Thr Tyr Ala Pro Pro Ala Arg Ala Ser Thr Arg Ala Thr Met Val 
        195                 200                 205             


Pro Glu Pro Thr Ser Ala Leu Pro Ser Asp Pro Arg Ser Pro Ala Ala 
    210                 215                 220                 


Trp Ser Asp Pro Gly Leu Arg Val Pro Pro Ala Ala Arg Ala His Leu 
225                 230                 235                 240 


Asp Asn Ser Ser Leu Gly Met Ser Gln Pro Arg Pro Ser Pro Gly Ala 
                245                 250                 255     


Phe Pro His Leu Ser Ser Glu Pro Arg Thr Pro Arg Ala Phe Pro Glu 
            260                 265                 270         


Pro Gly Ser Arg Val Pro Pro Ser Arg Leu Glu Cys Gln Gln Ala Leu 
        275                 280                 285             


Ser His Trp Leu Ser Asn Gln Val Pro Arg Arg Ala Gly Glu Arg Arg 
    290                 295                 300                 


Cys Pro Ala Met Ala Pro Arg Ala Arg Ser Ala Ser Gln Asp Arg Leu 
305                 310                 315                 320 


Glu Glu Val Ala Ala Pro Arg Pro Trp Pro Cys Ser Thr Ser Gln Asp 
                325                 330                 335     


Ala Leu Ser Gln Leu Gly Gln Glu Gly Trp His Arg Ala Arg Ser Asp 
            340                 345                 350         


Asp Tyr Leu Ser Arg Ala Thr Arg Ser Ala Glu Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Leu Val Ser Pro Arg Phe Glu Arg Cys Gly Trp Ala Ser Gln Arg 
    370                 375                 380                 


Ser Ser Ala Arg Thr Pro Ala Cys Pro Thr Arg Asp Leu Pro Gly Pro 
385                 390                 395                 400 


Gln Ala Pro Pro Pro Ser Gly Leu Gln Gly Leu Asp Asp Leu Gly Tyr 
                405                 410                 415     


Ile Gly Tyr Arg Ser Tyr Ser Pro Ser Phe Gln Arg Arg Thr Gly Leu 
            420                 425                 430         


Leu His Ala Leu Ser Phe Arg Asp Ser Pro Phe Gly Gly Leu Pro Thr 
        435                 440                 445             


Phe Asn Leu Ala Gln Ser Pro Ala Ser Phe Pro Pro Glu Ala Ser Glu 
    450                 455                 460                 


Pro Pro Arg Val Val Arg Pro Glu Pro Ser Thr Arg Ala Leu Glu Pro 
465                 470                 475                 480 


Pro Ala Glu Asp Arg Gly Asp Glu Val Val Leu Arg Gln Lys Pro Pro 
                485                 490                 495     


Thr Gly Arg Lys Val Gln Leu Thr Pro Ala Arg Gln Met Asn Leu Gly 
            500                 505                 510         


Phe Gly Asp Glu Ser Pro Glu Pro Glu Ala Ser Gly Arg Gly Glu Arg 
        515                 520                 525             


Leu Gly Arg Lys Val Ala Pro Leu Ala Thr Thr Glu Asp Ser Leu Ala 
    530                 535                 540                 


Ser Ile Pro Phe Ile Asp Glu Pro Thr Ser Pro Ser Ile Asp Leu Gln 
545                 550                 555                 560 


Ala Lys His Val Pro Ala Ser Ala Val Val Ser Ser Ala Met Asn Ser 
                565                 570                 575     


Ala Pro Val Leu Gly Thr Ser Pro Ser Ser Pro Thr Phe Thr Phe Thr 
            580                 585                 590         


Leu Gly Arg His Tyr Ser Gln Asp Cys Ser Ser Ile Lys Ala Gly Arg 
        595                 600                 605             


Arg Ser Ser Tyr Leu Leu Ala Ile Thr Thr Glu Arg Ser Lys Ser Cys 
    610                 615                 620                 


Asp Asp Gly Leu Asn Thr Phe Arg Asp Glu Gly Arg Val Leu Arg Arg 
625                 630                 635                 640 


Leu Pro Asn Arg Ile Pro Ser Leu Arg Met Leu Arg Ser Phe Phe Thr 
                645                 650                 655     


Asp Gly Ser Leu Asp Ser Trp Gly Thr Ser Glu Asp Ala Asp Ala Pro 
            660                 665                 670         


Ser Lys Arg His Ser Thr Ser Asp Leu Ser Asp Ala Thr Phe Ser Asp 
        675                 680                 685             


Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln Ile Leu Thr Lys Lys 
    690                 695                 700                 


Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys Arg Val Tyr Ala 
705                 710                 715                 720 


Ala Leu Arg Ala Arg Ser Leu Ser Leu Ser Lys Glu Arg Arg Glu Pro 
                725                 730                 735     


Gly Pro Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Gly Glu Asp Glu 
            740                 745                 750         


Ala Ala Pro Val Cys Ile Gly Ser Cys Leu Val Asp Ile Ser Tyr Ser 
        755                 760                 765             


Glu Thr Lys Arg Arg His Val Phe Arg Leu Thr Thr Ala Asp Phe Cys 
    770                 775                 780                 


Glu Tyr Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Gly Trp Ile 
785                 790                 795                 800 


Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro Gly Cys 
                805                 810                 815     


Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg Lys Val 
            820                 825                 830         


Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly Ser Arg 
        835                 840                 845             


Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala Ala Arg 
    850                 855                 860                 


Gly Leu Arg Thr Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp Ser Ala 
865                 870                 875                 880 


Ala Ala Pro Lys Thr Pro Trp Gly Ile Asn Ile Ile Lys Lys Asn Lys 
                885                 890                 895     


Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys Gln Pro 
            900                 905                 910         


Ala Thr Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys Cys Arg 
        915                 920                 925             


Ile Val Glu Ala Arg Gly Leu Glu Ser Thr Gly Ile Tyr Arg Val Pro 
    930                 935                 940                 


Gly Asn Asn Ala Val Val Ser Ser Leu Gln Glu Gln Leu Asn Arg Gly 
945                 950                 955                 960 


Pro Gly Asp Ile Asn Leu Gln Asp Glu Arg Trp Gln Asp Leu Asn Val 
                965                 970                 975     


Ile Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu 
            980                 985                 990         


Phe Thr Asp Asp Lys Tyr Asn Asp  Phe Ile Glu Ala Asn  Arg Ile Glu 
        995                 1000                 1005             


Asp Ala  Arg Glu Arg Met Arg  Thr Leu Arg Lys Leu  Ile Arg Asp 
    1010                 1015                 1020             


Leu Pro  Gly His Tyr Tyr Glu  Thr Leu Lys Phe Leu  Val Gly His 
    1025                 1030                 1035             


Leu Lys  Thr Ile Ala Asp His  Ser Glu Lys Asn Lys  Met Glu Pro 
    1040                 1045                 1050             


Arg Asn  Leu Ala Leu Val Phe  Gly Pro Thr Leu Val  Arg Thr Ser 
    1055                 1060                 1065             


Glu Asp  Asn Met Thr Asp Met  Val Thr His Met Pro  Asp Arg Tyr 
    1070                 1075                 1080             


Lys Ile  Val Glu Thr Leu Ile  Gln His Ser Asp Trp  Phe Phe Ser 
    1085                 1090                 1095             


Asp Glu  Glu Asp Lys Gly Glu  Arg Thr Pro Val Gly  Asp Lys Glu 
    1100                 1105                 1110             


Pro Gln  Ala Val Pro Asn Ile  Glu Tyr Leu Leu Pro  Asn Ile Gly 
    1115                 1120                 1125             


Arg Thr  Val Pro Pro Gly Asp  Pro Gly Ser Asp Ser  Thr Thr Cys 
    1130                 1135                 1140             


Ser Ser  Ala Lys Ser Lys Gly  Ser Trp Ala Pro Lys  Lys Glu Pro 
    1145                 1150                 1155             


Tyr Ala  Arg Glu Met Leu Ala  Ile Ser Phe Ile Ser  Ala Val Asn 
    1160                 1165                 1170             


Arg Lys  Arg Lys Lys Arg Arg  Glu Ala Arg Gly Leu  Gly Ser Ser 
    1175                 1180                 1185             


Thr Asp  Asp Asp Ser Glu Gln  Glu Ala His Lys Pro  Gly Ala Gly 
    1190                 1195                 1200             


Ala Thr  Ala Pro Gly Thr Gln  Glu Arg Pro Gln Gly  Pro Leu Pro 
    1205                 1210                 1215             


Gly Ala  Val Ala Pro Glu Ala  Pro Gly Arg Leu Ser  Pro Pro Ala 
    1220                 1225                 1230             


Ala Pro  Glu Glu Arg Pro Ala  Ala Asp Thr Arg Ser  Ile Val Ser 
    1235                 1240                 1245             


Gly Tyr  Ser Thr Leu Ser Thr  Met Asp Arg Ser Val  Cys Ser Gly 
    1250                 1255                 1260             


Ala Ser  Gly Arg Arg Ala Gly  Ala Gly Asp Glu Ala  Asp Asp Glu 
    1265                 1270                 1275             


Arg Ser  Glu Leu Ser His Val  Glu Thr Asp Thr Glu  Gly Ala Ala 
    1280                 1285                 1290             


Gly Ala  Gly Pro Gly Gly Arg  Leu Thr Arg Arg Pro  Ser Phe Ser 
    1295                 1300                 1305             


Ser His  His Leu Met Pro Cys  Asp Thr Leu Ala Arg  Arg Arg Leu 
    1310                 1315                 1320             


Ala Arg  Gly Arg Pro Asp Gly  Glu Gly Ala Gly Arg  Gly Gly Pro 
    1325                 1330                 1335             


Arg Ala  Pro Glu Pro Pro Gly  Ser Ala Ser Ser Ser  Ser Gln Glu 
    1340                 1345                 1350             


Ser Leu  Arg Pro Pro Ala Ala  Ala Leu Ala Ser Arg  Pro Ser Arg 
    1355                 1360                 1365             


Met Glu  Ala Leu Arg Leu Arg  Leu Arg Gly Thr Ala  Asp Asp Met 
    1370                 1375                 1380             


Leu Ala  Val Arg Leu Arg Arg  Pro Leu Ser Pro Glu  Thr Arg Arg 
    1385                 1390                 1395             


Arg Arg  Ser Ser Trp Arg Arg  His Thr Val Val Val  Gln Ser Pro 
    1400                 1405                 1410             


Leu Thr  Asp Leu Asn Phe Asn  Glu Trp Lys Glu Leu  Gly Gly Gly 
    1415                 1420                 1425             


Gly Pro  Pro Glu Pro Ala Gly  Ala Arg Ala His Ser  Asp Asn Lys 
    1430                 1435                 1440             


Asp Ser  Gly Leu Ser Ser Leu  Glu Ser Thr Lys Ala  Arg Ala Pro 
    1445                 1450                 1455             


Ser Ser  Ala Ala Ser Gln Pro  Pro Ala Pro Gly Asp  Thr Gly Ser 
    1460                 1465                 1470             


Leu Gln  Ser Gln Pro Pro Arg  Arg Ser Ala Ala Ser  Arg Leu His 
    1475                 1480                 1485             


Gln Cys  Leu 
    1490     


<210>  715
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP24__Homo_sapiens__NP_112595

<400>  715

Met Pro Glu Asp Arg Asn Ser Gly Gly Cys Pro Ala Gly Ala Leu Ala 
1               5                   10                  15      


Ser Thr Pro Phe Ile Pro Lys Thr Thr Tyr Arg Arg Ile Lys Arg Cys 
            20                  25                  30          


Phe Ser Phe Arg Lys Gly Ile Phe Gly Gln Lys Leu Glu Asp Thr Val 
        35                  40                  45              


Arg Tyr Glu Lys Arg Tyr Gly Asn Arg Leu Ala Pro Met Leu Val Glu 
    50                  55                  60                  


Gln Cys Val Asp Phe Ile Arg Gln Arg Gly Leu Lys Glu Glu Gly Leu 
65                  70                  75                  80  


Phe Arg Leu Pro Gly Gln Ala Asn Leu Val Lys Glu Leu Gln Asp Ala 
                85                  90                  95      


Phe Asp Cys Gly Glu Lys Pro Ser Phe Asp Ser Asn Thr Asp Val His 
            100                 105                 110         


Thr Val Ala Ser Leu Leu Lys Leu Tyr Leu Arg Glu Leu Pro Glu Pro 
        115                 120                 125             


Val Ile Pro Tyr Ala Lys Tyr Glu Asp Phe Leu Ser Cys Ala Lys Leu 
    130                 135                 140                 


Leu Ser Lys Glu Glu Glu Ala Gly Val Lys Glu Leu Ala Lys Gln Val 
145                 150                 155                 160 


Lys Ser Leu Pro Val Val Asn Tyr Asn Leu Leu Lys Tyr Ile Cys Arg 
                165                 170                 175     


Phe Leu Asp Glu Val Gln Ser Tyr Ser Gly Val Asn Lys Met Ser Val 
            180                 185                 190         


Gln Asn Leu Ala Thr Val Phe Gly Pro Asn Ile Leu Arg Pro Lys Val 
        195                 200                 205             


Glu Asp Pro Leu Thr Ile Met Glu Gly Thr Val Val Val Gln Gln Leu 
    210                 215                 220                 


Met Ser Val Met Ile Ser Lys His Asp Cys Leu Phe Pro Lys Asp Ala 
225                 230                 235                 240 


Glu Leu Gln Ser Lys Pro Gln Asp Gly Val Ser Asn Asn Asn Glu Ile 
                245                 250                 255     


Gln Lys Lys Ala Thr Met Gly Gln Leu Gln Asn Lys Glu Asn Asn Asn 
            260                 265                 270         


Thr Lys Asp Ser Pro Ser Arg Gln Cys Ser Trp Asp Lys Ser Glu Ser 
        275                 280                 285             


Pro Gln Arg Ser Ser Met Asn Asn Gly Ser Pro Thr Ala Leu Ser Gly 
    290                 295                 300                 


Ser Lys Thr Asn Ser Pro Lys Asn Ser Val His Lys Leu Asp Val Ser 
305                 310                 315                 320 


Arg Ser Pro Pro Leu Met Val Lys Lys Asn Pro Ala Phe Asn Lys Gly 
                325                 330                 335     


Ser Gly Ile Val Thr Asn Gly Ser Phe Ser Ser Ser Asn Ala Glu Gly 
            340                 345                 350         


Leu Glu Lys Thr Gln Thr Thr Pro Asn Gly Ser Leu Gln Ala Arg Arg 
        355                 360                 365             


Ser Ser Ser Leu Lys Val Ser Gly Thr Lys Met Gly Thr His Ser Val 
    370                 375                 380                 


Gln Asn Gly Thr Val Arg Met Gly Ile Leu Asn Ser Asp Thr Leu Gly 
385                 390                 395                 400 


Asn Pro Thr Asn Val Arg Asn Met Ser Trp Leu Pro Asn Gly Tyr Val 
                405                 410                 415     


Thr Leu Arg Asp Asn Lys Gln Lys Glu Gln Ala Gly Glu Leu Gly Gln 
            420                 425                 430         


His Asn Arg Leu Ser Thr Tyr Asp Asn Val His Gln Gln Phe Ser Met 
        435                 440                 445             


Met Asn Leu Asp Asp Lys Gln Ser Ile Asp Ser Ala Thr Trp Ser Thr 
    450                 455                 460                 


Ser Ser Cys Glu Ile Ser Leu Pro Glu Asn Ser Asn Ser Cys Arg Ser 
465                 470                 475                 480 


Ser Thr Thr Thr Cys Pro Glu Gln Asp Phe Phe Gly Gly Asn Phe Glu 
                485                 490                 495     


Asp Pro Val Leu Asp Gly Pro Pro Gln Asp Asp Leu Ser His Pro Arg 
            500                 505                 510         


Asp Tyr Glu Ser Lys Ser Asp His Arg Ser Val Gly Gly Arg Ser Ser 
        515                 520                 525             


Arg Ala Thr Ser Ser Ser Asp Asn Ser Glu Thr Phe Val Gly Asn Ser 
    530                 535                 540                 


Ser Ser Asn His Ser Ala Leu His Ser Leu Val Ser Ser Leu Lys Gln 
545                 550                 555                 560 


Glu Met Thr Lys Gln Lys Ile Glu Tyr Glu Ser Arg Ile Lys Ser Leu 
                565                 570                 575     


Glu Gln Arg Asn Leu Thr Leu Glu Thr Glu Met Met Ser Leu His Asp 
            580                 585                 590         


Glu Leu Asp Gln Glu Arg Lys Lys Phe Thr Met Ile Glu Ile Lys Met 
        595                 600                 605             


Arg Asn Ala Glu Arg Ala Lys Glu Asp Ala Glu Lys Arg Asn Asp Met 
    610                 615                 620                 


Leu Gln Lys Glu Met Glu Gln Phe Phe Ser Thr Phe Gly Glu Leu Thr 
625                 630                 635                 640 


Val Glu Pro Arg Arg Thr Glu Arg Gly Asn Thr Ile Trp Ile Gln 
                645                 650                 655 


<210>  716
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP25__Homo_sapiens__NP_001007232

<400>  716

Met Ser Leu Lys Leu Pro Arg Asn Trp Asp Phe Asn Leu Lys Val Glu 
1               5                   10                  15      


Ala Ala Lys Ile Ala Arg Ser Arg Ser Val Met Thr Gly Glu Gln Met 
            20                  25                  30          


Ala Ala Phe His Pro Ser Ser Thr Pro Asn Pro Leu Glu Arg Pro Ile 
        35                  40                  45              


Lys Met Gly Trp Leu Lys Lys Gln Arg Ser Ile Val Lys Asn Trp Gln 
    50                  55                  60                  


Gln Arg Tyr Phe Val Leu Arg Ala Gln Gln Leu Tyr Tyr Tyr Lys Asp 
65                  70                  75                  80  


Glu Glu Asp Thr Lys Pro Gln Gly Cys Met Tyr Leu Pro Gly Cys Thr 
                85                  90                  95      


Ile Lys Glu Ile Ala Thr Asn Pro Glu Glu Ala Gly Lys Phe Val Phe 
            100                 105                 110         


Glu Ile Ile Pro Ala Ser Trp Asp Gln Asn Arg Met Gly Gln Asp Ser 
        115                 120                 125             


Tyr Val Leu Met Ala Ser Ser Gln Ala Glu Met Glu Glu Trp Val Lys 
    130                 135                 140                 


Phe Leu Arg Arg Val Ala Gly Thr Pro Cys Gly Ala Val Phe Gly Gln 
145                 150                 155                 160 


Arg Leu Asp Glu Thr Val Ala Tyr Glu Gln Lys Phe Gly Pro His Leu 
                165                 170                 175     


Val Pro Ile Leu Val Glu Lys Cys Ala Glu Phe Ile Leu Glu His Gly 
            180                 185                 190         


Arg Asn Glu Glu Gly Ile Phe Arg Leu Pro Gly Gln Asp Asn Leu Val 
        195                 200                 205             


Lys Gln Leu Arg Asp Ala Phe Asp Ala Gly Glu Arg Pro Ser Phe Asp 
    210                 215                 220                 


Arg Asp Thr Asp Val His Thr Val Ala Ser Leu Leu Lys Leu Tyr Leu 
225                 230                 235                 240 


Arg Asp Leu Pro Glu Pro Val Val Pro Trp Ser Gln Tyr Glu Gly Phe 
                245                 250                 255     


Leu Leu Cys Gly Gln Leu Thr Asn Ala Asp Glu Ala Lys Ala Gln Gln 
            260                 265                 270         


Glu Leu Met Lys Gln Leu Ser Ile Leu Pro Arg Asp Asn Tyr Ser Leu 
        275                 280                 285             


Leu Ser Tyr Ile Cys Arg Phe Leu His Glu Ile Gln Leu Asn Cys Ala 
    290                 295                 300                 


Val Asn Lys Met Ser Val Asp Asn Leu Ala Thr Val Ile Gly Val Asn 
305                 310                 315                 320 


Leu Ile Arg Ser Lys Val Glu Asp Pro Ala Val Ile Met Arg Gly Thr 
                325                 330                 335     


Pro Gln Ile Gln Arg Val Met Thr Met Met Ile Arg Asp His Glu Val 
            340                 345                 350         


Leu Phe Pro Lys Ser Lys Asp Ile Pro Leu Ser Pro Pro Ala Gln Lys 
        355                 360                 365             


Asn Asp Pro Lys Lys Ala Pro Val Ala Arg Ser Ser Val Gly Trp Asp 
    370                 375                 380                 


Ala Thr Glu Asp Leu Arg Ile Ser Arg Thr Asp Ser Phe Ser Ser Met 
385                 390                 395                 400 


Thr Ser Asp Ser Asp Thr Thr Ser Pro Thr Gly Gln Gln Pro Ser Asp 
                405                 410                 415     


Ala Phe Pro Glu Asp Ser Ser Lys Val Pro Arg Glu Lys Pro Gly Asp 
            420                 425                 430         


Trp Lys Met Gln Ser Arg Lys Arg Thr Gln Thr Leu Pro Asn Arg Lys 
        435                 440                 445             


Cys Phe Leu Thr Ser Ala Phe Gln Gly Ala Asn Ser Ser Lys Met Glu 
    450                 455                 460                 


Ile Phe Lys Asn Glu Phe Trp Ser Pro Ser Ser Glu Ala Lys Ala Gly 
465                 470                 475                 480 


Glu Gly His Arg Arg Thr Met Ser Gln Asp Leu Arg Gln Leu Ser Asp 
                485                 490                 495     


Ser Gln Arg Thr Ser Thr Tyr Asp Asn Val Pro Ser Leu Pro Gly Ser 
            500                 505                 510         


Pro Gly Glu Glu Ala Ser Ala Leu Ser Ser Gln Ala Cys Asp Ser Lys 
        515                 520                 525             


Gly Asp Thr Leu Ala Ser Pro Asn Ser Glu Thr Gly Pro Gly Lys Lys 
    530                 535                 540                 


Asn Ser Gly Glu Glu Glu Ile Asp Ser Leu Gln Arg Met Val Gln Glu 
545                 550                 555                 560 


Leu Arg Lys Glu Ile Glu Thr Gln Lys Gln Met Tyr Glu Glu Gln Ile 
                565                 570                 575     


Lys Asn Leu Glu Lys Glu Asn Tyr Asp Val Trp Ala Lys Val Val Arg 
            580                 585                 590         


Leu Asn Glu Glu Leu Glu Lys Glu Lys Lys Lys Ser Ala Ala Leu Glu 
        595                 600                 605             


Ile Ser Leu Arg Asn Met Glu Arg Ser Arg Glu Asp Val Glu Lys Arg 
    610                 615                 620                 


Asn Lys Ala Leu Glu Glu Glu Val Lys Glu Phe Val Lys Ser Met Lys 
625                 630                 635                 640 


Glu Pro Lys Thr Glu Ala 
                645     


<210>  717
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP26__Homo_sapiens__NP_001129080

<400>  717

Met Gly Leu Pro Ala Leu Glu Phe Ser Asp Cys Cys Leu Asp Ser Pro 
1               5                   10                  15      


His Phe Arg Glu Thr Leu Lys Ser His Glu Ala Glu Leu Asp Lys Thr 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Lys Ser Leu Ile Ser 
        35                  40                  45              


Ala Leu Lys Asn Leu Ser Ser Ala Lys Arg Lys Phe Ala Asp Ser Leu 
    50                  55                  60                  


Asn Glu Phe Lys Phe Gln Cys Ile Gly Asp Ala Glu Thr Asp Asp Glu 
65                  70                  75                  80  


Met Cys Ile Ala Arg Ser Leu Gln Glu Phe Ala Thr Val Leu Arg Asn 
                85                  90                  95      


Leu Glu Asp Glu Arg Ile Arg Met Ile Glu Asn Ala Ser Glu Val Leu 
            100                 105                 110         


Ile Thr Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile Gly Ala Ala Lys 
        115                 120                 125             


Glu Ala Lys Lys Lys Tyr Asp Lys Glu Thr Glu Lys Tyr Cys Gly Ile 
    130                 135                 140                 


Leu Glu Lys His Leu Asn Leu Ser Ser Lys Lys Lys Glu Ser Gln Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Ser Gln Val Asp Leu Val Arg Gln His Phe Tyr Glu 
                165                 170                 175     


Val Ser Leu Glu Tyr Val Phe Lys Val Gln Glu Val Gln Glu Arg Lys 
            180                 185                 190         


Met Phe Glu Phe Val Glu Pro Leu Leu Ala Phe Leu Gln Gly Leu Phe 
        195                 200                 205             


Thr Phe Tyr His His Gly Tyr Glu Leu Ala Lys Asp Phe Gly Asp Phe 
    210                 215                 220                 


Lys Thr Gln Leu Thr Ile Ser Ile Gln Asn Thr Arg Asn Arg Phe Glu 
225                 230                 235                 240 


Gly Thr Arg Ser Glu Val Glu Ser Leu Met Lys Lys Met Lys Glu Asn 
                245                 250                 255     


Pro Leu Glu His Lys Thr Ile Ser Pro Tyr Thr Met Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg His Phe Gly Thr Ser Trp Val Lys His Tyr 
        275                 280                 285             


Cys Thr Tyr Gln Arg Asp Ser Lys Gln Ile Thr Met Val Pro Phe Asp 
    290                 295                 300                 


Gln Lys Ser Gly Gly Lys Gly Gly Glu Asp Glu Ser Val Ile Leu Lys 
305                 310                 315                 320 


Ser Cys Thr Arg Arg Lys Thr Asp Ser Ile Glu Lys Arg Phe Cys Phe 
                325                 330                 335     


Asp Val Glu Ala Val Asp Arg Pro Gly Val Ile Thr Met Gln Ala Leu 
            340                 345                 350         


Ser Glu Glu Asp Arg Arg Leu Trp Met Glu Ala Met Asp Gly Arg Glu 
        355                 360                 365             


Pro Val Tyr Asn Ser Asn Lys Asp Ser Gln Ser Glu Gly Thr Ala Gln 
    370                 375                 380                 


Leu Asp Ser Ile Gly Phe Ser Ile Ile Arg Lys Cys Ile His Ala Val 
385                 390                 395                 400 


Glu Thr Arg Gly Ile Asn Glu Gln Gly Leu Tyr Arg Ile Val Gly Val 
                405                 410                 415     


Asn Ser Arg Val Gln Lys Leu Leu Ser Val Leu Met Asp Pro Lys Thr 
            420                 425                 430         


Ala Ser Glu Thr Glu Thr Asp Ile Cys Ala Glu Trp Glu Ile Lys Thr 
        435                 440                 445             


Ile Thr Ser Ala Leu Lys Thr Tyr Leu Arg Met Leu Pro Gly Pro Leu 
    450                 455                 460                 


Met Met Tyr Gln Phe Gln Arg Ser Phe Ile Lys Ala Ala Lys Leu Glu 
465                 470                 475                 480 


Asn Gln Glu Ser Arg Val Ser Glu Ile His Ser Leu Val His Arg Leu 
                485                 490                 495     


Pro Glu Lys Asn Arg Gln Met Leu Gln Leu Leu Met Asn His Leu Ala 
            500                 505                 510         


Asn Val Ala Asn Asn His Lys Gln Asn Leu Met Thr Val Ala Asn Leu 
        515                 520                 525             


Gly Val Val Phe Gly Pro Thr Leu Leu Arg Pro Gln Glu Glu Thr Val 
    530                 535                 540                 


Ala Ala Ile Met Asp Ile Lys Phe Gln Asn Ile Val Ile Glu Ile Leu 
545                 550                 555                 560 


Ile Glu Asn His Glu Lys Ile Phe Asn Thr Val Pro Asp Met Pro Leu 
                565                 570                 575     


Thr Asn Ala Gln Leu His Leu Ser Arg Lys Lys Ser Ser Asp Ser Lys 
            580                 585                 590         


Pro Pro Ser Cys Ser Glu Arg Pro Leu Thr Leu Phe His Thr Val Gln 
        595                 600                 605             


Ser Thr Glu Lys Gln Glu Gln Arg Asn Ser Ile Ile Asn Ser Ser Leu 
    610                 615                 620                 


Glu Ser Val Ser Ser Asn Pro Asn Ser Ile Leu Asn Ser Ser Ser Ser 
625                 630                 635                 640 


Leu Gln Pro Asn Met Asn Ser Ser Asp Pro Asp Leu Ala Val Val Lys 
                645                 650                 655     


Pro Thr Arg Pro Asn Ser Leu Pro Pro Asn Pro Ser Pro Thr Ser Pro 
            660                 665                 670         


Leu Ser Pro Ser Trp Pro Met Phe Ser Ala Pro Ser Ser Pro Met Pro 
        675                 680                 685             


Thr Ser Ser Thr Ser Ser Asp Ser Ser Pro Val Ser Thr Pro Phe Arg 
    690                 695                 700                 


Lys Ala Lys Ala Leu Tyr Ala Cys Lys Ala Glu His Asp Ser Glu Leu 
705                 710                 715                 720 


Ser Phe Thr Ala Gly Thr Val Phe Asp Asn Val His Pro Ser Gln Glu 
                725                 730                 735     


Pro Gly Trp Leu Glu Gly Thr Leu Asn Gly Lys Thr Gly Leu Ile Pro 
            740                 745                 750         


Glu Asn Tyr Val Glu Phe Leu 
        755                 


<210>  718
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP27__Homo_sapiens__NP_777579

<400>  718

Met Ala Ala Asp Val Val Gly Asp Val Tyr Val Leu Val Glu His Pro 
1               5                   10                  15      


Phe Glu Tyr Thr Gly Lys Asp Gly Arg Arg Val Ala Ile Arg Pro Asn 
            20                  25                  30          


Glu Arg Tyr Arg Leu Leu Arg Arg Ser Thr Glu His Trp Trp His Val 
        35                  40                  45              


Arg Arg Glu Pro Gly Gly Arg Pro Phe Tyr Leu Pro Ala Gln Tyr Val 
    50                  55                  60                  


Arg Glu Leu Pro Ala Leu Gly Asn Pro Ala Ala Ala Ala Pro Pro Gly 
65                  70                  75                  80  


Pro His Pro Ser Pro Ala Ala Pro Glu Pro Leu Ala Tyr Asp Tyr Arg 
                85                  90                  95      


Phe Val Ser Ala Ala Ala Thr Ala Gly Pro Asp Gly Ala Pro Glu Glu 
            100                 105                 110         


Ser Gly Gly Arg Ala Ser Ser Leu Cys Gly Pro Ala Gln Arg Gly Ala 
        115                 120                 125             


Ala Thr Gln Arg Ser Ser Leu Ala Pro Gly Leu Pro Ala Cys Leu Tyr 
    130                 135                 140                 


Leu Arg Pro Ala Ala Pro Val Arg Pro Ala Gln Ser Leu Asn Asp Leu 
145                 150                 155                 160 


Ala Cys Ala Ala Val Ser Pro Pro Ala Gly Leu Leu Gly Ser Ser Gly 
                165                 170                 175     


Ser Phe Lys Ala Cys Ser Val Ala Gly Ser Trp Val Cys Pro Arg Pro 
            180                 185                 190         


Leu Ala Arg Ser Asp Ser Glu Asn Val Tyr Glu Val Ile Gln Asp Leu 
        195                 200                 205             


His Val Pro Pro Pro Glu Glu Ser Ala Glu Gln Val Pro Pro Arg Ala 
    210                 215                 220                 


Leu Gly Arg Gly Gly Gly Trp Arg Ala Arg Asp Arg Ala Arg Thr Glu 
225                 230                 235                 240 


Pro Gly Arg Lys Glu Thr Arg Ser Ala Gln Arg Arg Ala Arg Arg Pro 
                245                 250                 255     


Pro Leu Ser Glu Asp Phe Gly 
            260             


<210>  719
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP28__Homo_sapiens__NP_001010000

<400>  719

Met Arg Lys Lys Asp Lys Gln Ser Ile Arg Asp Val Arg Asp Ile Phe 
1               5                   10                  15      


Gly Val Ser Glu Ser Pro Pro Arg Asp Thr Cys Gly Asn His Thr Asn 
            20                  25                  30          


Gln Leu Asp Gly Thr Lys Glu Glu Arg Glu Leu Pro Arg Val Ile Lys 
        35                  40                  45              


Thr Ser Gly Ser Met Pro Asp Asp Ala Ser Leu Asn Ser Thr Thr Leu 
    50                  55                  60                  


Ser Asp Ala Ser Gln Asp Lys Glu Gly Ser Phe Ala Val Pro Arg Ser 
65                  70                  75                  80  


Asp Ser Val Ala Ile Leu Glu Thr Ile Pro Val Leu Pro Val His Ser 
                85                  90                  95      


Asn Gly Ser Pro Glu Pro Gly Gln Pro Val Gln Asn Ala Ile Ser Asp 
            100                 105                 110         


Asp Asp Phe Leu Glu Lys Asn Ile Pro Pro Glu Ala Glu Glu Leu Ser 
        115                 120                 125             


Phe Glu Val Ser Tyr Ser Glu Met Val Thr Glu Ala Leu Lys Arg Asn 
    130                 135                 140                 


Lys Leu Lys Lys Ser Glu Ile Lys Lys Glu Asp Tyr Val Leu Thr Lys 
145                 150                 155                 160 


Phe Asn Val Gln Lys Thr Arg Phe Gly Leu Thr Glu Ala Gly Asp Leu 
                165                 170                 175     


Ser Ala Glu Asp Met Lys Lys Ile Arg His Leu Ser Leu Ile Glu Leu 
            180                 185                 190         


Thr Ala Phe Phe Asp Ala Phe Gly Ile Gln Leu Lys Arg Asn Lys Thr 
        195                 200                 205             


Glu Lys Val Lys Gly Arg Asp Asn Gly Ile Phe Gly Val Pro Leu Thr 
    210                 215                 220                 


Val Leu Leu Asp Gly Asp Arg Lys Lys Asp Pro Gly Val Lys Val Pro 
225                 230                 235                 240 


Leu Val Leu Gln Lys Phe Phe Glu Lys Val Glu Glu Ser Gly Leu Glu 
                245                 250                 255     


Ser Glu Gly Ile Phe Arg Leu Ser Gly Cys Thr Ala Lys Val Lys Gln 
            260                 265                 270         


Tyr Arg Glu Glu Leu Asp Ala Lys Phe Asn Ala Asp Lys Phe Lys Trp 
        275                 280                 285             


Asp Lys Met Cys His Arg Glu Ala Ala Val Met Leu Lys Ala Phe Phe 
    290                 295                 300                 


Arg Glu Leu Pro Thr Ser Leu Phe Pro Val Glu Tyr Ile Pro Ala Phe 
305                 310                 315                 320 


Ile Ser Leu Met Glu Arg Gly Pro His Val Lys Val Gln Phe Gln Ala 
                325                 330                 335     


Leu His Leu Met Val Met Ala Leu Pro Asp Ala Asn Arg Asp Ala Ala 
            340                 345                 350         


Gln Ala Leu Met Thr Phe Phe Asn Lys Val Ile Ala Asn Glu Ser Lys 
        355                 360                 365             


Asn Arg Met Ser Leu Trp Asn Ile Ser Thr Val Met Ala Pro Asn Leu 
    370                 375                 380                 


Phe Phe Ser Arg Ser Lys His Ser Asp Tyr Glu Glu Leu Leu Leu Ala 
385                 390                 395                 400 


Asn Thr Ala Ala His Ile Ile Arg Leu Met Leu Lys Tyr Gln Lys Ile 
                405                 410                 415     


Leu Trp Lys Val Pro Ser Phe Leu Ile Thr Gln Val Arg Arg Met Asn 
            420                 425                 430         


Glu Ala Thr Met Leu Leu Lys Lys Gln Leu Pro Ser Val Arg Lys Leu 
        435                 440                 445             


Leu Arg Arg Lys Thr Leu Glu Arg Glu Thr Ala Ser Pro Lys Thr Ser 
    450                 455                 460                 


Lys Val Leu Gln Lys Ser Pro Ser Ala Arg Arg Met Ser Asp Val Pro 
465                 470                 475                 480 


Glu Gly Val Ile Arg Val His Ala Pro Leu Leu Ser Lys Val Ser Met 
                485                 490                 495     


Ala Ile Gln Leu Asn Asn Gln Thr Lys Ala Lys Asp Ile Leu Ala Lys 
            500                 505                 510         


Phe Gln Tyr Glu Asn Ser His Gly Ser Ser Glu Cys Ile Lys Ile Gln 
        515                 520                 525             


Asn Gln Arg Leu Tyr Glu Ile Gly Gly Asn Ile Gly Glu His Cys Leu 
    530                 535                 540                 


Asp Pro Asp Ala Tyr Ile Leu Asp Val Tyr Arg Ile Asn Pro Gln Ala 
545                 550                 555                 560 


Glu Trp Val Ile Lys Pro Gln Gln Ser Ser 
                565                 570 


<210>  720
<211>  1101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP30__Homo_sapiens__NP_001020769

<400>  720

Met Lys Ser Arg Gln Lys Gly Lys Lys Lys Gly Ser Ala Lys Glu Arg 
1               5                   10                  15      


Val Phe Gly Cys Asp Leu Gln Glu His Leu Gln His Ser Gly Gln Glu 
            20                  25                  30          


Val Pro Gln Val Leu Lys Ser Cys Ala Glu Phe Val Glu Glu Tyr Gly 
        35                  40                  45              


Val Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ser Ser Asn Ile Gln 
    50                  55                  60                  


Lys Leu Arg Gln Glu Phe Glu Ser Glu Arg Lys Pro Asp Leu Arg Arg 
65                  70                  75                  80  


Asp Val Tyr Leu Gln Asp Ile His Cys Val Ser Ser Leu Cys Lys Ala 
                85                  90                  95      


Tyr Phe Arg Glu Leu Pro Asp Pro Leu Leu Thr Tyr Arg Leu Tyr Asp 
            100                 105                 110         


Lys Phe Ala Glu Ala Val Gly Val Gln Leu Glu Pro Glu Arg Leu Val 
        115                 120                 125             


Lys Ile Leu Glu Val Leu Arg Glu Leu Pro Val Pro Asn Tyr Arg Thr 
    130                 135                 140                 


Leu Glu Phe Leu Met Arg His Leu Val His Met Ala Ser Phe Ser Ala 
145                 150                 155                 160 


Gln Thr Asn Met His Ala Arg Asn Leu Ala Ile Val Trp Ala Pro Asn 
                165                 170                 175     


Leu Leu Arg Ser Lys Asp Ile Glu Ala Ser Gly Phe Asn Gly Thr Ala 
            180                 185                 190         


Ala Phe Met Glu Val Arg Val Gln Ser Ile Val Val Glu Phe Ile Leu 
        195                 200                 205             


Thr His Val Asp Gln Leu Phe Gly Gly Ala Ala Leu Ser Gly Gly Glu 
    210                 215                 220                 


Val Glu Ser Gly Trp Arg Ser Leu Pro Gly Thr Arg Ala Ser Gly Ser 
225                 230                 235                 240 


Pro Glu Asp Leu Met Pro Arg Pro Leu Pro Tyr His Leu Pro Ser Ile 
                245                 250                 255     


Leu Gln Ala Gly Asp Gly Pro Pro Gln Met Arg Pro Tyr His Thr Ile 
            260                 265                 270         


Ile Glu Ile Ala Glu His Lys Arg Lys Gly Ser Leu Lys Val Arg Lys 
        275                 280                 285             


Trp Arg Ser Ile Phe Asn Leu Gly Arg Ser Gly His Glu Thr Lys Arg 
    290                 295                 300                 


Lys Leu Pro Arg Gly Ala Glu Asp Arg Glu Asp Lys Ser Asn Lys Gly 
305                 310                 315                 320 


Thr Leu Arg Pro Ala Lys Ser Met Asp Ser Leu Ser Ala Ala Ala Gly 
                325                 330                 335     


Ala Ser Asp Glu Pro Glu Gly Leu Val Gly Pro Ser Ser Pro Arg Pro 
            340                 345                 350         


Ser Pro Leu Leu Pro Glu Ser Leu Glu Asn Asp Ser Ile Glu Ala Ala 
        355                 360                 365             


Glu Gly Glu Gln Glu Pro Glu Ala Glu Ala Leu Gly Gly Thr Asn Ser 
    370                 375                 380                 


Glu Pro Gly Thr Pro Arg Ala Gly Arg Ser Ala Ile Arg Ala Gly Gly 
385                 390                 395                 400 


Ser Ser Arg Ala Glu Arg Cys Ala Gly Val His Ile Ser Asp Pro Tyr 
                405                 410                 415     


Asn Val Asn Leu Pro Leu His Ile Thr Ser Ile Leu Ser Val Pro Pro 
            420                 425                 430         


Asn Ile Ile Ser Asn Val Ser Leu Ala Arg Leu Thr Arg Gly Leu Glu 
        435                 440                 445             


Cys Pro Ala Leu Gln His Arg Pro Ser Pro Ala Ser Gly Pro Gly Pro 
    450                 455                 460                 


Gly Pro Gly Leu Gly Pro Gly Pro Pro Asp Glu Lys Leu Glu Ala Ser 
465                 470                 475                 480 


Pro Ala Ser Ser Pro Leu Ala Asp Ser Gly Pro Asp Asp Leu Ala Pro 
                485                 490                 495     


Ala Leu Glu Asp Ser Leu Ser Gln Glu Val Gln Asp Ser Phe Ser Phe 
            500                 505                 510         


Leu Glu Asp Ser Ser Ser Ser Glu Pro Glu Trp Val Gly Ala Glu Asp 
        515                 520                 525             


Gly Glu Val Ala Gln Ala Glu Ala Ala Gly Ala Ala Phe Ser Pro Gly 
    530                 535                 540                 


Glu Asp Asp Pro Gly Met Gly Tyr Leu Glu Glu Leu Leu Gly Val Gly 
545                 550                 555                 560 


Pro Gln Val Glu Glu Phe Ser Val Glu Pro Pro Leu Asp Asp Leu Ser 
                565                 570                 575     


Leu Asp Glu Ala Gln Phe Val Leu Ala Pro Ser Cys Cys Ser Leu Asp 
            580                 585                 590         


Ser Ala Gly Pro Arg Pro Glu Val Glu Glu Glu Asn Gly Glu Glu Val 
        595                 600                 605             


Phe Leu Ser Ala Tyr Asp Asp Leu Ser Pro Leu Leu Gly Pro Lys Pro 
    610                 615                 620                 


Pro Ile Trp Lys Gly Ser Gly Ser Leu Glu Gly Glu Ala Ala Gly Cys 
625                 630                 635                 640 


Gly Arg Gln Ala Leu Gly Gln Gly Gly Glu Glu Gln Ala Cys Trp Glu 
                645                 650                 655     


Val Gly Glu Asp Lys Gln Ala Glu Pro Gly Gly Arg Leu Asp Ile Arg 
            660                 665                 670         


Glu Glu Ala Glu Gly Ser Pro Glu Thr Lys Val Glu Ala Gly Lys Ala 
        675                 680                 685             


Ser Glu Asp Arg Gly Glu Ala Gly Gly Ser Gln Glu Thr Lys Val Arg 
    690                 695                 700                 


Leu Arg Glu Gly Ser Arg Glu Glu Thr Glu Ala Lys Glu Glu Lys Ser 
705                 710                 715                 720 


Lys Gly Gln Lys Lys Ala Asp Ser Met Glu Ala Lys Gly Val Glu Glu 
                725                 730                 735     


Pro Gly Gly Asp Glu Tyr Thr Asp Glu Lys Glu Lys Glu Ile Glu Arg 
            740                 745                 750         


Glu Glu Asp Glu Gln Arg Glu Glu Ala Gln Val Glu Ala Gly Arg Asp 
        755                 760                 765             


Leu Glu Gln Gly Ala Gln Glu Asp Gln Val Ala Glu Glu Lys Trp Glu 
    770                 775                 780                 


Val Val Gln Lys Gln Glu Ala Glu Gly Val Arg Glu Asp Glu Asp Lys 
785                 790                 795                 800 


Gly Gln Arg Glu Lys Gly Tyr His Glu Ala Arg Lys Asp Gln Gly Asp 
                805                 810                 815     


Gly Glu Asp Ser Arg Ser Pro Glu Ala Ala Thr Glu Gly Gly Ala Gly 
            820                 825                 830         


Glu Val Ser Lys Glu Arg Glu Ser Gly Asp Gly Glu Ala Glu Gly Asp 
        835                 840                 845             


Gln Arg Ala Gly Gly Tyr Tyr Leu Glu Glu Asp Thr Leu Ser Glu Gly 
    850                 855                 860                 


Ser Gly Val Ala Ser Leu Glu Val Asp Cys Ala Lys Glu Gly Asn Pro 
865                 870                 875                 880 


His Ser Ser Glu Met Glu Glu Val Ala Pro Gln Pro Pro Gln Pro Glu 
                885                 890                 895     


Glu Met Glu Pro Glu Gly Gln Pro Ser Pro Asp Gly Cys Leu Cys Pro 
            900                 905                 910         


Cys Ser Leu Gly Leu Gly Gly Val Gly Met Arg Leu Ala Ser Thr Leu 
        915                 920                 925             


Val Gln Val Gln Gln Val Arg Ser Val Pro Val Val Pro Pro Lys Pro 
    930                 935                 940                 


Gln Phe Ala Lys Met Pro Ser Ala Met Cys Ser Lys Ile His Val Ala 
945                 950                 955                 960 


Pro Ala Asn Pro Cys Pro Arg Pro Gly Arg Leu Asp Gly Thr Pro Gly 
                965                 970                 975     


Glu Arg Ala Trp Gly Ser Arg Ala Ser Arg Ser Ser Trp Arg Asn Gly 
            980                 985                 990         


Gly Ser Leu Ser Phe Asp Ala Ala  Val Ala Leu Ala Arg  Asp Arg Gln 
        995                 1000                 1005             


Arg Thr  Glu Ala Gln Gly Val  Arg Arg Thr Gln Thr  Cys Thr Glu 
    1010                 1015                 1020             


Gly Gly  Asp Tyr Cys Leu Ile  Pro Arg Thr Ser Pro  Cys Ser Met 
    1025                 1030                 1035             


Ile Ser  Ala His Ser Pro Arg  Pro Leu Ser Cys Leu  Glu Leu Pro 
    1040                 1045                 1050             


Ser Glu  Gly Ala Glu Gly Ser  Gly Ser Arg Ser Arg  Leu Ser Leu 
    1055                 1060                 1065             


Pro Pro  Arg Glu Pro Gln Val  Pro Asp Pro Leu Leu  Ser Ser Gln 
    1070                 1075                 1080             


Arg Arg  Ser Tyr Ala Phe Glu  Thr Gln Ala Asn Pro  Gly Lys Gly 
    1085                 1090                 1095             


Glu Gly  Leu 
    1100     


<210>  721
<211>  1444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP31__Homo_sapiens__NP_065805

<400>  721

Met Lys Asn Lys Gly Ala Lys Gln Lys Leu Lys Arg Lys Gly Ala Ala 
1               5                   10                  15      


Ser Ala Phe Gly Cys Asp Leu Thr Glu Tyr Leu Glu Ser Ser Gly Gln 
            20                  25                  30          


Asp Val Pro Tyr Val Leu Lys Ser Cys Ala Glu Phe Ile Glu Thr His 
        35                  40                  45              


Gly Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Thr Ser Asn Ile 
    50                  55                  60                  


Gln Arg Leu Arg Gln Glu Phe Gly Ser Asp Gln Cys Pro Asp Leu Thr 
65                  70                  75                  80  


Arg Glu Val Tyr Leu Gln Asp Ile His Cys Val Gly Ser Leu Cys Lys 
                85                  90                  95      


Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Glu Leu Tyr 
            100                 105                 110         


Glu Lys Phe Thr Glu Ala Val Ser His Cys Pro Glu Glu Gly Gln Leu 
        115                 120                 125             


Ala Arg Ile Gln Asn Val Ile Gln Glu Leu Pro Pro Ser His Tyr Arg 
    130                 135                 140                 


Thr Leu Glu Tyr Leu Ile Arg His Leu Ala His Ile Ala Ser Phe Ser 
145                 150                 155                 160 


Ser Lys Thr Asn Met His Ala Arg Asn Leu Ala Leu Val Trp Ala Pro 
                165                 170                 175     


Asn Leu Leu Arg Ser Lys Glu Ile Glu Ala Thr Gly Cys Asn Gly Asp 
            180                 185                 190         


Ala Ala Phe Leu Ala Val Arg Val Gln Gln Val Val Ile Glu Phe Ile 
        195                 200                 205             


Leu Asn His Val Asp Gln Ile Phe Asn Asn Gly Ala Pro Gly Ser Leu 
    210                 215                 220                 


Glu Asn Asp Glu Asn Arg Pro Ile Met Lys Ser Leu Thr Leu Pro Ala 
225                 230                 235                 240 


Leu Ser Leu Pro Met Lys Leu Val Ser Leu Glu Glu Ala Gln Ala Arg 
                245                 250                 255     


Ser Leu Ala Thr Asn His Pro Ala Arg Lys Glu Arg Arg Glu Asn Ser 
            260                 265                 270         


Leu Pro Glu Ile Val Pro Pro Met Gly Thr Leu Phe His Thr Val Leu 
        275                 280                 285             


Glu Leu Pro Asp Asn Lys Arg Lys Leu Ser Ser Lys Ser Lys Lys Trp 
    290                 295                 300                 


Lys Ser Ile Phe Asn Leu Gly Arg Ser Gly Ser Asp Ser Lys Ser Lys 
305                 310                 315                 320 


Leu Ser Arg Asn Gly Ser Val Phe Val Arg Gly Gln Arg Leu Ser Val 
                325                 330                 335     


Glu Lys Ala Thr Ile Arg Pro Ala Lys Ser Met Asp Ser Leu Cys Ser 
            340                 345                 350         


Val Pro Val Glu Gly Lys Glu Thr Lys Gly Asn Phe Asn Arg Thr Val 
        355                 360                 365             


Thr Thr Gly Gly Phe Phe Ile Pro Ala Thr Lys Met His Ser Thr Gly 
    370                 375                 380                 


Thr Gly Ser Ser Cys Asp Leu Thr Lys Gln Glu Gly Glu Trp Gly Gln 
385                 390                 395                 400 


Glu Gly Met Pro Pro Gly Ala Glu Gly Gly Phe Asp Val Ser Ser Asp 
                405                 410                 415     


Arg Ser His Leu Gln Gly Ala Gln Ala Arg Pro Pro Pro Glu Gln Leu 
            420                 425                 430         


Lys Val Phe Arg Pro Val Glu Asp Pro Glu Ser Glu Gln Thr Ala Pro 
        435                 440                 445             


Lys Met Leu Gly Met Phe Tyr Thr Ser Asn Asp Ser Pro Ser Lys Ser 
    450                 455                 460                 


Val Phe Thr Ser Ser Leu Phe Gln Met Glu Pro Ser Pro Arg Asn Gln 
465                 470                 475                 480 


Arg Lys Ala Leu Asn Ile Ser Glu Pro Phe Ala Val Ser Val Pro Leu 
                485                 490                 495     


Arg Val Ser Ala Val Ile Ser Thr Asn Ser Thr Pro Cys Arg Thr Pro 
            500                 505                 510         


Pro Lys Glu Leu Gln Ser Leu Ser Ser Leu Glu Glu Phe Ser Phe His 
        515                 520                 525             


Gly Ser Glu Ser Gly Gly Trp Pro Glu Glu Glu Lys Pro Leu Gly Ala 
    530                 535                 540                 


Glu Thr Ser Ala Ala Ser Val Pro Lys Lys Ala Gly Leu Glu Asp Ala 
545                 550                 555                 560 


Lys Ala Val Pro Glu Ala Pro Gly Thr Val Glu Cys Ser Lys Gly Leu 
                565                 570                 575     


Ser Gln Glu Pro Gly Ala His Leu Glu Glu Lys Lys Thr Pro Glu Ser 
            580                 585                 590         


Ser Leu Ser Ser Gln His Leu Asn Glu Leu Glu Lys Arg Pro Asn Pro 
        595                 600                 605             


Glu Lys Val Val Glu Glu Gly Arg Glu Ala Gly Glu Met Glu Ser Ser 
    610                 615                 620                 


Thr Leu Gln Glu Ser Pro Arg Ala Arg Ala Glu Ala Val Leu Leu His 
625                 630                 635                 640 


Glu Met Asp Glu Asp Asp Leu Ala Asn Ala Leu Ile Trp Pro Glu Ile 
                645                 650                 655     


Gln Gln Glu Leu Lys Ile Ile Glu Ser Glu Glu Glu Leu Ser Ser Leu 
            660                 665                 670         


Pro Pro Pro Ala Leu Lys Thr Ser Pro Ile Gln Pro Ile Leu Glu Ser 
        675                 680                 685             


Ser Leu Gly Pro Phe Ile Pro Ser Glu Pro Pro Gly Ser Leu Pro Cys 
    690                 695                 700                 


Gly Ser Phe Pro Ala Pro Val Ser Thr Pro Leu Glu Val Trp Thr Arg 
705                 710                 715                 720 


Asp Pro Ala Asn Gln Ser Thr Gln Gly Ala Ser Thr Ala Ala Ser Arg 
                725                 730                 735     


Glu Lys Pro Glu Pro Glu Gln Gly Leu His Pro Asp Leu Ala Ser Leu 
            740                 745                 750         


Ala Pro Leu Glu Ile Val Pro Phe Glu Lys Ala Ser Pro Gln Ala Thr 
        755                 760                 765             


Val Glu Val Gly Gly Pro Gly Asn Leu Ser Pro Pro Leu Pro Pro Ala 
    770                 775                 780                 


Pro Pro Pro Pro Thr Pro Leu Glu Glu Ser Thr Pro Val Leu Leu Ser 
785                 790                 795                 800 


Lys Gly Gly Pro Glu Arg Glu Asp Ser Ser Arg Lys Leu Arg Thr Asp 
                805                 810                 815     


Leu Tyr Ile Asp Gln Leu Lys Ser Gln Asp Ser Pro Glu Ile Ser Ser 
            820                 825                 830         


Leu Cys Gln Gly Glu Glu Ala Thr Pro Arg His Ser Asp Lys Gln Asn 
        835                 840                 845             


Ser Lys Asn Ala Ala Ser Glu Gly Lys Gly Cys Gly Phe Pro Ser Pro 
    850                 855                 860                 


Thr Arg Glu Val Glu Ile Val Ser Gln Glu Glu Glu Asp Val Thr His 
865                 870                 875                 880 


Ser Val Gln Glu Pro Ser Asp Cys Asp Glu Asp Asp Thr Val Thr Asp 
                885                 890                 895     


Ile Ala Gln His Gly Leu Glu Met Val Glu Pro Trp Glu Glu Pro Gln 
            900                 905                 910         


Trp Val Thr Ser Pro Leu His Ser Pro Thr Leu Lys Asp Ala His Lys 
        915                 920                 925             


Ala Gln Val Gln Gly Leu Gln Gly His Gln Leu Glu Lys Arg Leu Ser 
    930                 935                 940                 


His Arg Pro Ser Leu Arg Gln Ser His Ser Leu Asp Ser Lys Pro Thr 
945                 950                 955                 960 


Val Lys Ser Gln Trp Thr Leu Glu Val Pro Ser Ser Ser Ser Cys Ala 
                965                 970                 975     


Asn Leu Glu Thr Glu Arg Asn Ser Asp Pro Leu Gln Pro Gln Ala Pro 
            980                 985                 990         


Arg Arg Glu Ile Thr Gly Trp Asp  Glu Lys Ala Leu Arg  Ser Phe Arg 
        995                 1000                 1005             


Glu Phe  Ser Gly Leu Lys Gly  Ala Glu Ala Pro Pro  Asn Gln Lys 
    1010                 1015                 1020             


Gly Pro  Ser Gly Val Gln Pro  Asn Pro Ala Glu Thr  Ser Pro Ile 
    1025                 1030                 1035             


Ser Leu  Ala Glu Gly Lys Glu  Leu Gly Thr His Leu  Gly His Ser 
    1040                 1045                 1050             


Ser Pro  Gln Ile Arg Gln Gly  Gly Val Pro Gly Pro  Glu Ser Ser 
    1055                 1060                 1065             


Lys Glu  Ser Ser Pro Ser Val  Gln Asp Ser Thr Ser  Pro Gly Glu 
    1070                 1075                 1080             


His Pro  Ala Lys Leu Gln Leu  Lys Ser Thr Glu Cys  Gly Pro Pro 
    1085                 1090                 1095             


Lys Gly  Lys Asn Arg Pro Ser  Ser Leu Asn Leu Asp  Pro Ala Ile 
    1100                 1105                 1110             


Pro Ile  Ala Asp Leu Phe Trp  Phe Glu Asn Val Ala  Ser Phe Ser 
    1115                 1120                 1125             


Ser Pro  Gly Met Gln Val Ser  Glu Pro Gly Asp Pro  Lys Val Thr 
    1130                 1135                 1140             


Trp Met  Thr Ser Ser Tyr Cys  Lys Ala Asp Pro Trp  Arg Val Tyr 
    1145                 1150                 1155             


Ser Gln  Asp Pro Gln Asp Leu  Asp Ile Val Ala His  Ala Leu Thr 
    1160                 1165                 1170             


Gly Arg  Arg Asn Ser Ala Pro  Val Ser Val Ser Ala  Val Arg Thr 
    1175                 1180                 1185             


Ser Phe  Met Val Lys Met Cys  Gln Ala Arg Ala Val  Pro Val Ile 
    1190                 1195                 1200             


Pro Pro  Lys Ile Gln Tyr Thr  Gln Ile Pro Gln Pro  Leu Pro Ser 
    1205                 1210                 1215             


Gln Ser  Ser Gly Glu Asn Gly  Val Gln Pro Leu Glu  Arg Ser Gln 
    1220                 1225                 1230             


Glu Gly  Pro Ser Ser Thr Ser  Gly Thr Thr Gln Lys  Pro Ala Lys 
    1235                 1240                 1245             


Asp Asp  Ser Pro Ser Ser Leu  Glu Ser Ser Lys Glu  Glu Lys Pro 
    1250                 1255                 1260             


Lys Gln  Asp Pro Gly Ala Ile  Lys Ser Ser Pro Val  Asp Ala Thr 
    1265                 1270                 1275             


Ala Pro  Cys Met Cys Glu Gly  Pro Thr Leu Ser Pro  Glu Pro Gly 
    1280                 1285                 1290             


Ser Ser  Asn Leu Leu Ser Thr  Gln Asp Ala Val Val  Gln Cys Arg 
    1295                 1300                 1305             


Lys Arg  Met Ser Glu Thr Glu  Pro Ser Gly Asp Asn  Leu Leu Ser 
    1310                 1315                 1320             


Ser Lys  Leu Glu Arg Pro Ser  Gly Gly Ser Lys Pro  Phe His Arg 
    1325                 1330                 1335             


Ser Arg  Pro Gly Arg Pro Gln  Ser Leu Ile Leu Phe  Ser Pro Pro 
    1340                 1345                 1350             


Phe Pro  Ile Met Asp His Leu  Pro Pro Ser Ser Thr  Val Thr Asp 
    1355                 1360                 1365             


Ser Lys  Val Leu Leu Ser Pro  Ile Arg Ser Pro Thr  Gln Thr Val 
    1370                 1375                 1380             


Ser Pro  Gly Leu Leu Cys Gly  Glu Leu Ala Glu Asn  Thr Trp Val 
    1385                 1390                 1395             


Thr Pro  Glu Gly Val Thr Leu  Arg Asn Lys Met Thr  Ile Pro Lys 
    1400                 1405                 1410             


Asn Gly  Gln Arg Leu Glu Thr  Ser Thr Ser Cys Phe  Tyr Gln Pro 
    1415                 1420                 1425             


Gln Arg  Arg Ser Val Ile Leu  Asp Gly Arg Ser Gly  Arg Gln Ile 
    1430                 1435                 1440             


Glu 
    


<210>  722
<211>  2087
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP32__Homo_sapiens__NP_001136157

<400>  722

Met Glu Thr Glu Ser Glu Ser Ser Thr Leu Gly Asp Asp Ser Val Phe 
1               5                   10                  15      


Trp Leu Glu Ser Glu Val Ile Ile Gln Val Thr Asp Cys Glu Glu Glu 
            20                  25                  30          


Glu Arg Glu Glu Lys Phe Arg Lys Met Lys Ser Ser Val His Ser Glu 
        35                  40                  45              


Glu Asp Asp Phe Val Pro Glu Leu His Arg Asn Val His Pro Arg Glu 
    50                  55                  60                  


Arg Pro Asp Trp Glu Glu Thr Leu Ser Ala Met Ala Arg Gly Ala Asp 
65                  70                  75                  80  


Val Pro Glu Ile Pro Gly Asp Leu Thr Leu Lys Thr Cys Gly Ser Thr 
                85                  90                  95      


Ala Ser Met Lys Val Lys His Val Lys Lys Leu Pro Phe Thr Lys Gly 
            100                 105                 110         


His Phe Pro Lys Met Ala Glu Cys Ala His Phe His Tyr Glu Asn Val 
        115                 120                 125             


Glu Phe Gly Ser Ile Gln Leu Ser Leu Ser Glu Glu Gln Asn Glu Val 
    130                 135                 140                 


Met Lys Asn Gly Cys Glu Ser Lys Glu Leu Val Tyr Leu Val Gln Ile 
145                 150                 155                 160 


Ala Cys Gln Gly Lys Ser Trp Ile Val Lys Arg Ser Tyr Glu Asp Phe 
                165                 170                 175     


Arg Val Leu Asp Lys His Leu His Leu Cys Ile Tyr Asp Arg Arg Phe 
            180                 185                 190         


Ser Gln Leu Ser Glu Leu Pro Arg Ser Asp Thr Leu Lys Asp Ser Pro 
        195                 200                 205             


Glu Ser Val Thr Gln Met Leu Met Ala Tyr Leu Ser Arg Leu Ser Ala 
    210                 215                 220                 


Ile Ala Gly Asn Lys Ile Asn Cys Gly Pro Ala Leu Thr Trp Met Glu 
225                 230                 235                 240 


Ile Asp Asn Lys Gly Asn His Leu Leu Val His Glu Glu Ser Ser Ile 
                245                 250                 255     


Asn Thr Pro Ala Val Gly Ala Ala His Val Ile Lys Arg Tyr Thr Ala 
            260                 265                 270         


Arg Ala Pro Asp Glu Leu Thr Leu Glu Val Gly Asp Ile Val Ser Val 
        275                 280                 285             


Ile Asp Met Pro Pro Lys Val Leu Ser Thr Trp Trp Arg Gly Lys His 
    290                 295                 300                 


Gly Phe Gln Val Gly Leu Phe Pro Gly His Cys Val Glu Leu Ile Asn 
305                 310                 315                 320 


Gln Lys Val Pro Gln Ser Val Thr Asn Ser Val Pro Lys Pro Val Ser 
                325                 330                 335     


Lys Lys His Gly Lys Leu Ile Thr Phe Leu Arg Thr Phe Met Lys Ser 
            340                 345                 350         


Arg Pro Thr Lys Gln Lys Leu Lys Gln Arg Gly Ile Leu Lys Glu Arg 
        355                 360                 365             


Val Phe Gly Cys Asp Leu Gly Glu His Leu Leu Asn Ser Gly Phe Glu 
    370                 375                 380                 


Val Pro Gln Val Leu Gln Ser Cys Thr Ala Phe Ile Glu Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ala Ser Asn Ile Gln 
                405                 410                 415     


Arg Leu Arg His Glu Phe Asp Ser Glu His Val Pro Asp Leu Thr Lys 
            420                 425                 430         


Glu Pro Tyr Val Gln Asp Ile His Ser Val Gly Ser Leu Cys Lys Leu 
        435                 440                 445             


Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gln Leu Tyr Glu 
    450                 455                 460                 


Lys Phe Ser Asp Ala Val Ser Ala Ala Thr Asp Glu Glu Arg Leu Ile 
465                 470                 475                 480 


Lys Ile His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg Thr 
                485                 490                 495     


Leu Glu Phe Leu Met Arg His Leu Ser Leu Leu Ala Asp Tyr Cys Ser 
            500                 505                 510         


Ile Thr Asn Met His Ala Lys Asn Leu Ala Ile Val Trp Ala Pro Asn 
        515                 520                 525             


Leu Leu Arg Ser Lys Gln Ile Glu Ser Ala Cys Phe Ser Gly Thr Ala 
    530                 535                 540                 


Ala Phe Met Glu Val Arg Ile Gln Ser Val Val Val Glu Phe Ile Leu 
545                 550                 555                 560 


Asn His Val Asp Val Leu Phe Ser Gly Arg Ile Ser Met Ala Met Gln 
                565                 570                 575     


Glu Gly Ala Ala Ser Leu Ser Arg Pro Lys Ser Leu Leu Val Ser Ser 
            580                 585                 590         


Pro Ser Thr Lys Leu Leu Thr Leu Glu Glu Ala Gln Ala Arg Thr Gln 
        595                 600                 605             


Ala Gln Val Asn Ser Pro Ile Val Thr Glu Asn Lys Tyr Ile Glu Val 
    610                 615                 620                 


Gly Glu Gly Pro Ala Ala Leu Gln Gly Lys Phe His Thr Ile Ile Glu 
625                 630                 635                 640 


Phe Pro Leu Glu Arg Lys Arg Pro Gln Asn Lys Met Lys Lys Ser Pro 
                645                 650                 655     


Val Gly Ser Trp Arg Ser Phe Phe Asn Leu Gly Lys Ser Ser Ser Val 
            660                 665                 670         


Ser Lys Arg Lys Leu Gln Arg Asn Glu Ser Glu Pro Ser Glu Met Lys 
        675                 680                 685             


Ala Met Ala Leu Lys Gly Gly Arg Ala Glu Gly Thr Leu Arg Ser Ala 
    690                 695                 700                 


Lys Ser Glu Glu Ser Leu Thr Ser Leu His Ala Val Asp Gly Asp Ser 
705                 710                 715                 720 


Lys Leu Phe Arg Pro Arg Arg Pro Arg Ser Ser Ser Asp Ala Leu Ser 
                725                 730                 735     


Ala Ser Phe Asn Gly Glu Met Leu Gly Asn Arg Cys Asn Ser Tyr Asp 
            740                 745                 750         


Asn Leu Pro His Asp Asn Glu Ser Glu Glu Glu Gly Gly Leu Leu His 
        755                 760                 765             


Ile Pro Ala Leu Met Ser Pro His Ser Ala Glu Asp Val Asp Leu Ser 
    770                 775                 780                 


Pro Pro Asp Ile Gly Val Ala Ser Leu Asp Phe Asp Pro Met Ser Phe 
785                 790                 795                 800 


Gln Cys Ser Pro Pro Lys Ala Glu Ser Glu Cys Leu Glu Ser Gly Ala 
                805                 810                 815     


Ser Phe Leu Asp Ser Pro Gly Tyr Ser Lys Asp Lys Pro Ser Ala Asn 
            820                 825                 830         


Lys Lys Asp Ala Glu Thr Gly Ser Ser Gln Cys Gln Thr Pro Gly Ser 
        835                 840                 845             


Thr Ala Ser Ser Glu Pro Val Ser Pro Leu Gln Glu Lys Leu Ser Pro 
    850                 855                 860                 


Phe Phe Thr Leu Asp Leu Ser Pro Thr Glu Asp Lys Ser Ser Lys Pro 
865                 870                 875                 880 


Ser Ser Phe Thr Glu Lys Val Val Tyr Ala Phe Ser Pro Lys Ile Gly 
                885                 890                 895     


Arg Lys Leu Ser Lys Ser Pro Ser Met Ser Ile Ser Glu Pro Ile Ser 
            900                 905                 910         


Val Thr Leu Pro Pro Arg Val Ser Glu Val Ile Gly Thr Val Ser Asn 
        915                 920                 925             


Thr Thr Ala Gln Asn Ala Ser Ser Ser Thr Trp Asp Lys Cys Val Glu 
    930                 935                 940                 


Glu Arg Asp Ala Thr Asn Arg Ser Pro Thr Gln Ile Val Lys Met Lys 
945                 950                 955                 960 


Thr Asn Glu Thr Val Ala Gln Glu Ala Tyr Glu Ser Glu Val Gln Pro 
                965                 970                 975     


Leu Asp Gln Val Ala Ala Glu Glu Val Glu Leu Pro Gly Lys Glu Asp 
            980                 985                 990         


Gln Ser Val Ser Ser Ser Gln Ser  Lys Ala Val Ala Ser  Gly Gln Thr 
        995                 1000                 1005             


Gln Thr  Gly Ala Val Thr His  Asp Pro Pro Gln Asp  Ser Val Pro 
    1010                 1015                 1020             


Val Ser  Ser Val Ser Leu Ile  Pro Pro Pro Pro Pro  Pro Lys Asn 
    1025                 1030                 1035             


Val Ala  Arg Met Leu Ala Leu  Ala Leu Ala Glu Ser  Ala Gln Gln 
    1040                 1045                 1050             


Ala Ser  Thr Gln Ser Leu Lys  Arg Pro Gly Thr Ser  Gln Ala Gly 
    1055                 1060                 1065             


Tyr Thr  Asn Tyr Gly Asp Ile  Ala Val Ala Thr Thr  Glu Asp Asn 
    1070                 1075                 1080             


Leu Ser  Ser Ser Tyr Ser Ala  Val Ala Leu Asp Lys  Ala Tyr Phe 
    1085                 1090                 1095             


Gln Thr  Asp Arg Pro Ala Glu  Gln Phe His Leu Gln  Asn Asn Ala 
    1100                 1105                 1110             


Pro Gly  Asn Cys Asp His Pro  Leu Pro Glu Thr Thr  Ala Thr Gly 
    1115                 1120                 1125             


Asp Pro  Thr His Ser Asn Thr  Thr Glu Ser Gly Glu  Gln His His 
    1130                 1135                 1140             


Gln Val  Asp Leu Thr Gly Asn  Gln Pro His Gln Ala  Tyr Leu Ser 
    1145                 1150                 1155             


Gly Asp  Pro Glu Lys Ala Arg  Ile Thr Ser Val Pro  Leu Asp Ser 
    1160                 1165                 1170             


Glu Lys  Ser Asp Asp His Val  Ser Phe Pro Glu Asp  Gln Ser Gly 
    1175                 1180                 1185             


Lys Asn  Ser Met Pro Thr Val  Ser Phe Leu Asp Gln  Asp Gln Ser 
    1190                 1195                 1200             


Pro Pro  Arg Phe Tyr Ser Gly  Asp Gln Pro Pro Ser  Tyr Leu Gly 
    1205                 1210                 1215             


Ala Ser  Val Asp Lys Leu His  His Pro Leu Glu Phe  Ala Asp Lys 
    1220                 1225                 1230             


Ser Pro  Thr Pro Pro Asn Leu  Pro Ser Asp Lys Ile  Tyr Pro Pro 
    1235                 1240                 1245             


Ser Gly  Ser Pro Glu Glu Asn  Thr Ser Thr Ala Thr  Met Thr Tyr 
    1250                 1255                 1260             


Met Thr  Thr Thr Pro Ala Thr  Ala Gln Met Ser Thr  Lys Glu Ala 
    1265                 1270                 1275             


Ser Trp  Asp Val Ala Glu Gln  Pro Thr Thr Ala Asp  Phe Ala Ala 
    1280                 1285                 1290             


Ala Thr  Leu Gln Arg Thr His  Arg Thr Asn Arg Pro  Leu Pro Pro 
    1295                 1300                 1305             


Pro Pro  Ser Gln Arg Ser Ala  Glu Gln Pro Pro Val  Val Gly Gln 
    1310                 1315                 1320             


Val Gln  Ala Ala Thr Asn Ile  Gly Leu Asn Asn Ser  His Lys Val 
    1325                 1330                 1335             


Gln Gly  Val Val Pro Val Pro  Glu Arg Pro Pro Glu  Pro Arg Ala 
    1340                 1345                 1350             


Met Asp  Asp Pro Ala Ser Ala  Phe Ile Ser Asp Ser  Gly Ala Ala 
    1355                 1360                 1365             


Ala Ala  Gln Cys Pro Met Ala  Thr Ala Val Gln Pro  Gly Leu Pro 
    1370                 1375                 1380             


Glu Lys  Val Arg Asp Gly Ala  Arg Val Pro Leu Leu  His Leu Arg 
    1385                 1390                 1395             


Ala Glu  Ser Val Pro Ala His  Pro Cys Gly Phe Pro  Ala Pro Leu 
    1400                 1405                 1410             


Pro Pro  Thr Arg Met Met Glu  Ser Lys Met Ile Ala  Ala Ile His 
    1415                 1420                 1425             


Ser Ser  Ser Ala Asp Ala Thr  Ser Ser Ser Asn Tyr  His Ser Phe 
    1430                 1435                 1440             


Val Thr  Ala Ser Ser Thr Ser  Val Asp Asp Ala Leu  Pro Leu Pro 
    1445                 1450                 1455             


Leu Pro  Val Pro Gln Pro Lys  His Ala Ser Gln Lys  Thr Val Tyr 
    1460                 1465                 1470             


Ser Ser  Phe Ala Arg Pro Asp  Val Thr Thr Glu Pro  Phe Gly Pro 
    1475                 1480                 1485             


Asp Asn  Cys Leu His Phe Asn  Met Thr Pro Asn Cys  Gln Tyr Arg 
    1490                 1495                 1500             


Pro Gln  Ser Val Pro Pro His  His Asn Lys Leu Glu  Gln His Gln 
    1505                 1510                 1515             


Val Tyr  Gly Ala Arg Ser Glu  Pro Pro Ala Ser Met  Gly Leu Arg 
    1520                 1525                 1530             


Tyr Asn  Thr Tyr Val Ala Pro  Gly Arg Asn Ala Ser  Gly His His 
    1535                 1540                 1545             


Ser Lys  Pro Cys Ser Arg Val  Glu Tyr Val Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


Ser Val  Arg Asn Thr Cys Tyr  Pro Glu Asp Ile Pro  Pro Tyr Pro 
    1565                 1570                 1575             


Thr Ile  Arg Arg Val Gln Ser  Leu His Ala Pro Pro  Ser Ser Met 
    1580                 1585                 1590             


Ile Arg  Ser Val Pro Ile Ser  Arg Thr Glu Val Pro  Pro Asp Asp 
    1595                 1600                 1605             


Glu Pro  Ala Tyr Cys Pro Arg  Pro Leu Tyr Gln Tyr  Lys Pro Tyr 
    1610                 1615                 1620             


Gln Ser  Ser Gln Ala Arg Ser  Asp Tyr His Val Thr  Gln Leu Gln 
    1625                 1630                 1635             


Pro Tyr  Phe Glu Asn Gly Arg  Val His Tyr Arg Tyr  Ser Pro Tyr 
    1640                 1645                 1650             


Ser Ser  Ser Ser Ser Ser Tyr  Tyr Ser Pro Asp Gly  Ala Leu Cys 
    1655                 1660                 1665             


Asp Val  Asp Ala Tyr Gly Thr  Val Gln Leu Arg Pro  Leu His Arg 
    1670                 1675                 1680             


Leu Pro  Asn Arg Asp Phe Ala  Phe Tyr Asn Pro Arg  Leu Gln Gly 
    1685                 1690                 1695             


Lys Ser  Leu Tyr Ser Tyr Ala  Gly Leu Ala Pro Arg  Pro Arg Ala 
    1700                 1705                 1710             


Asn Val  Thr Gly Tyr Phe Ser  Pro Asn Asp His Asn  Val Val Ser 
    1715                 1720                 1725             


Met Pro  Pro Ala Ala Asp Val  Lys His Thr Tyr Thr  Ser Trp Asp 
    1730                 1735                 1740             


Leu Glu  Asp Met Glu Lys Tyr  Arg Met Gln Ser Ile  Arg Arg Glu 
    1745                 1750                 1755             


Ser Arg  Ala Arg Gln Lys Val  Lys Gly Pro Val Met  Ser Gln Tyr 
    1760                 1765                 1770             


Asp Asn  Met Thr Pro Ala Val  Gln Asp Asp Leu Gly  Gly Ile Tyr 
    1775                 1780                 1785             


Val Ile  His Leu Arg Ser Lys  Ser Asp Pro Gly Lys  Thr Gly Leu 
    1790                 1795                 1800             


Leu Ser  Val Ala Glu Gly Lys  Glu Ser Arg His Ala  Ala Lys Ala 
    1805                 1810                 1815             


Ile Ser  Pro Glu Gly Glu Asp  Arg Phe Tyr Arg Arg  His Pro Glu 
    1820                 1825                 1830             


Ala Glu  Met Asp Arg Ala His  His His Gly Gly His  Gly Ser Thr 
    1835                 1840                 1845             


Gln Pro  Glu Lys Pro Ser Leu  Pro Gln Lys Gln Ser  Ser Leu Arg 
    1850                 1855                 1860             


Ser Arg  Lys Leu Pro Asp Met  Gly Cys Ser Leu Pro  Glu His Arg 
    1865                 1870                 1875             


Ala His  Gln Glu Ala Ser His  Arg Gln Phe Cys Glu  Ser Lys Asn 
    1880                 1885                 1890             


Gly Pro  Pro Tyr Pro Gln Gly  Ala Gly Gln Leu Asp  Tyr Gly Ser 
    1895                 1900                 1905             


Lys Gly  Ile Pro Asp Thr Ser  Glu Pro Val Ser Tyr  His Asn Ser 
    1910                 1915                 1920             


Gly Val  Lys Tyr Ala Ala Ser  Gly Gln Glu Ser Leu  Arg Leu Asn 
    1925                 1930                 1935             


His Lys  Glu Val Arg Leu Ser  Lys Glu Met Glu Arg  Pro Trp Val 
    1940                 1945                 1950             


Arg Gln  Pro Ser Ala Pro Glu  Lys His Ser Arg Asp  Cys Tyr Lys 
    1955                 1960                 1965             


Glu Glu  Glu His Leu Thr Gln  Ser Ile Val Pro Pro  Pro Lys Pro 
    1970                 1975                 1980             


Glu Arg  Ser His Ser Leu Lys  Leu His His Thr Gln  Asn Val Glu 
    1985                 1990                 1995             


Arg Asp  Pro Ser Val Leu Tyr  Gln Tyr Gln Pro His  Gly Lys Arg 
    2000                 2005                 2010             


Gln Ser  Ser Val Thr Val Val  Ser Gln Tyr Asp Asn  Leu Glu Asp 
    2015                 2020                 2025             


Tyr His  Ser Leu Pro Gln His  Gln Arg Gly Val Phe  Gly Gly Gly 
    2030                 2035                 2040             


Gly Met  Gly Thr Tyr Val Pro  Pro Gly Phe Pro His  Pro Gln Ser 
    2045                 2050                 2055             


Arg Thr  Tyr Ala Thr Ala Leu  Gly Gln Gly Ala Phe  Leu Pro Ala 
    2060                 2065                 2070             


Glu Leu  Ser Leu Gln His Pro  Glu Thr Gln Ile His  Ala Glu 
    2075                 2080                 2085         


<210>  723
<211>  1499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP35__Homo_sapiens__NP_004482

<400>  723

Met Met Met Ala Arg Lys Gln Asp Val Arg Ile Pro Thr Tyr Asn Ile 
1               5                   10                  15      


Ser Val Val Gly Leu Ser Gly Thr Glu Lys Glu Lys Gly Gln Cys Gly 
            20                  25                  30          


Ile Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Pro Ser Ala Asp 
        35                  40                  45              


Glu Phe His Leu Asp His Thr Ser Val Leu Ser Thr Ser Asp Phe Gly 
    50                  55                  60                  


Gly Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Glu Val Ser 
65                  70                  75                  80  


Arg Ser Leu Glu Asp Cys Val Glu Cys Lys Met His Ile Val Glu Gln 
                85                  90                  95      


Thr Glu Phe Ile Asp Asp Gln Thr Phe Gln Pro His Arg Ser Thr Ala 
            100                 105                 110         


Leu Gln Pro Tyr Ile Lys Arg Ala Ala Ala Thr Lys Leu Ala Ser Ala 
        115                 120                 125             


Glu Lys Leu Met Tyr Phe Cys Thr Asp Gln Leu Gly Leu Glu Gln Asp 
    130                 135                 140                 


Phe Glu Gln Lys Gln Met Pro Asp Gly Lys Leu Leu Val Asp Gly Phe 
145                 150                 155                 160 


Leu Leu Gly Ile Asp Val Ser Arg Gly Met Asn Arg Asn Phe Asp Asp 
                165                 170                 175     


Gln Leu Lys Phe Val Ser Asn Leu Tyr Asn Gln Leu Ala Lys Thr Lys 
            180                 185                 190         


Lys Pro Ile Val Val Val Leu Thr Lys Cys Asp Glu Gly Val Glu Arg 
        195                 200                 205             


Tyr Ile Arg Asp Ala His Thr Phe Ala Leu Ser Lys Lys Asn Leu Gln 
    210                 215                 220                 


Val Val Glu Thr Ser Ala Arg Ser Asn Val Asn Val Asp Leu Ala Phe 
225                 230                 235                 240 


Ser Thr Leu Val Gln Leu Ile Asp Lys Ser Arg Gly Lys Thr Lys Ile 
                245                 250                 255     


Ile Pro Tyr Phe Glu Ala Leu Lys Gln Gln Ser Gln Gln Ile Ala Thr 
            260                 265                 270         


Ala Lys Asp Lys Tyr Glu Trp Leu Val Ser Arg Ile Val Lys Asn His 
        275                 280                 285             


Asn Glu Asn Trp Leu Ser Val Ser Arg Lys Met Gln Ala Ser Pro Glu 
    290                 295                 300                 


Tyr Gln Asp Tyr Val Tyr Leu Glu Gly Thr Gln Lys Ala Lys Lys Leu 
305                 310                 315                 320 


Phe Leu Gln His Ile His Arg Leu Lys His Glu His Ile Glu Arg Arg 
                325                 330                 335     


Arg Lys Leu Tyr Leu Ala Ala Leu Pro Leu Ala Phe Glu Ala Leu Ile 
            340                 345                 350         


Pro Asn Leu Asp Glu Ile Asp His Leu Ser Cys Ile Lys Ala Lys Lys 
        355                 360                 365             


Leu Leu Glu Thr Lys Pro Glu Phe Leu Lys Trp Phe Val Val Leu Glu 
    370                 375                 380                 


Glu Thr Pro Trp Asp Ala Thr Ser His Ile Asp Asn Met Glu Asn Glu 
385                 390                 395                 400 


Arg Ile Pro Phe Asp Leu Met Asp Thr Val Pro Ala Glu Gln Leu Tyr 
                405                 410                 415     


Glu Ala His Leu Glu Lys Leu Arg Asn Glu Arg Lys Arg Val Glu Met 
            420                 425                 430         


Arg Arg Ala Phe Lys Glu Asn Leu Glu Thr Ser Pro Phe Ile Thr Pro 
        435                 440                 445             


Gly Lys Pro Trp Glu Glu Ala Arg Ser Phe Ile Met Asn Glu Asp Phe 
    450                 455                 460                 


Tyr Gln Trp Leu Glu Glu Ser Val Tyr Met Asp Ile Tyr Gly Lys His 
465                 470                 475                 480 


Gln Lys Gln Ile Ile Asp Lys Ala Lys Glu Glu Phe Gln Glu Leu Leu 
                485                 490                 495     


Leu Glu Tyr Ser Glu Leu Phe Tyr Glu Leu Glu Leu Asp Ala Lys Pro 
            500                 505                 510         


Ser Lys Glu Lys Met Gly Val Ile Gln Asp Val Leu Gly Glu Glu Gln 
        515                 520                 525             


Arg Phe Lys Ala Leu Gln Lys Leu Gln Ala Glu Arg Asp Ala Leu Ile 
    530                 535                 540                 


Leu Lys His Ile His Phe Val Tyr His Pro Thr Lys Glu Thr Cys Pro 
545                 550                 555                 560 


Ser Cys Pro Ala Cys Val Asp Ala Lys Ile Glu His Leu Ile Ser Ser 
                565                 570                 575     


Arg Phe Ile Arg Pro Ser Asp Arg Asn Gln Lys Asn Ser Leu Ser Asp 
            580                 585                 590         


Pro Asn Ile Asp Arg Ile Asn Leu Val Ile Leu Gly Lys Asp Gly Leu 
        595                 600                 605             


Ala Arg Glu Leu Ala Asn Glu Ile Arg Ala Leu Cys Thr Asn Asp Asp 
    610                 615                 620                 


Lys Tyr Val Ile Asp Gly Lys Met Tyr Glu Leu Ser Leu Arg Pro Ile 
625                 630                 635                 640 


Glu Gly Asn Val Arg Leu Pro Val Asn Ser Phe Gln Thr Pro Thr Phe 
                645                 650                 655     


Gln Pro His Gly Cys Leu Cys Leu Tyr Asn Ser Lys Glu Ser Leu Ser 
            660                 665                 670         


Tyr Val Val Glu Ser Ile Glu Lys Ser Arg Glu Ser Thr Leu Gly Arg 
        675                 680                 685             


Arg Asp Asn His Leu Val His Leu Pro Leu Thr Leu Ile Leu Val Asn 
    690                 695                 700                 


Lys Arg Gly Asp Thr Ser Gly Glu Thr Leu His Ser Leu Ile Gln Gln 
705                 710                 715                 720 


Gly Gln Gln Ile Ala Ser Lys Leu Gln Cys Val Phe Leu Asp Pro Ala 
                725                 730                 735     


Ser Ala Gly Ile Gly Tyr Gly Arg Asn Ile Asn Glu Lys Gln Ile Ser 
            740                 745                 750         


Gln Val Leu Lys Gly Leu Leu Asp Ser Lys Arg Asn Leu Asn Leu Val 
        755                 760                 765             


Ser Ser Thr Ala Ser Ile Lys Asp Leu Ala Asp Val Asp Leu Arg Ile 
    770                 775                 780                 


Val Met Cys Leu Met Cys Gly Asp Pro Phe Ser Ala Asp Asp Ile Leu 
785                 790                 795                 800 


Phe Pro Val Leu Gln Ser Gln Thr Cys Lys Ser Ser His Cys Gly Ser 
                805                 810                 815     


Asn Asn Ser Val Leu Leu Glu Leu Pro Ile Gly Leu His Lys Lys Arg 
            820                 825                 830         


Ile Glu Leu Ser Val Leu Ser Tyr His Ser Ser Phe Ser Ile Arg Lys 
        835                 840                 845             


Ser Arg Leu Val His Gly Tyr Ile Val Phe Tyr Ser Ala Lys Arg Lys 
    850                 855                 860                 


Ala Ser Leu Ala Met Leu Arg Ala Phe Leu Cys Glu Val Gln Asp Ile 
865                 870                 875                 880 


Ile Pro Ile Gln Leu Val Ala Leu Thr Asp Gly Ala Val Asp Val Leu 
                885                 890                 895     


Asp Asn Asp Leu Ser Arg Glu Gln Leu Thr Glu Gly Glu Glu Ile Ala 
            900                 905                 910         


Gln Glu Ile Asp Gly Arg Phe Thr Ser Ile Pro Cys Ser Gln Pro Gln 
        915                 920                 925             


His Lys Leu Glu Ile Phe His Pro Phe Phe Lys Asp Val Val Glu Lys 
    930                 935                 940                 


Lys Asn Ile Ile Glu Ala Thr His Met Tyr Asp Asn Ala Ala Glu Ala 
945                 950                 955                 960 


Cys Ser Thr Thr Glu Glu Val Phe Asn Ser Pro Arg Ala Gly Ser Pro 
                965                 970                 975     


Leu Cys Asn Ser Asn Leu Gln Asp Ser Glu Glu Asp Ile Glu Pro Ser 
            980                 985                 990         


Tyr Ser Leu Phe Arg Glu Asp Thr  Ser Leu Pro Ser Leu  Ser Lys Asp 
        995                 1000                 1005             


His Ser  Lys Leu Ser Met Glu  Leu Glu Gly Asn Asp  Gly Leu Ser 
    1010                 1015                 1020             


Phe Ile  Met Ser Asn Phe Glu  Ser Lys Leu Asn Asn  Lys Val Pro 
    1025                 1030                 1035             


Pro Pro  Val Lys Pro Lys Pro  Pro Val His Phe Glu  Ile Thr Lys 
    1040                 1045                 1050             


Gly Asp  Leu Ser Tyr Leu Asp  Gln Gly His Arg Asp  Gly Gln Arg 
    1055                 1060                 1065             


Lys Ser  Val Ser Ser Ser Pro  Trp Leu Pro Gln Asp  Gly Phe Asp 
    1070                 1075                 1080             


Pro Ser  Asp Tyr Ala Glu Pro  Met Asp Ala Val Val  Lys Pro Arg 
    1085                 1090                 1095             


Asn Glu  Glu Glu Asn Ile Tyr  Ser Val Pro His Asp  Ser Thr Gln 
    1100                 1105                 1110             


Gly Lys  Ile Ile Thr Ile Arg  Asn Ile Asn Lys Ala  Gln Ser Asn 
    1115                 1120                 1125             


Gly Ser  Gly Asn Gly Ser Asp  Ser Glu Met Asp Thr  Ser Ser Leu 
    1130                 1135                 1140             


Glu Arg  Gly Arg Lys Val Ser  Ile Val Ser Lys Pro  Val Leu Tyr 
    1145                 1150                 1155             


Arg Thr  Arg Cys Thr Arg Leu  Gly Arg Phe Ala Ser  Tyr Arg Thr 
    1160                 1165                 1170             


Ser Phe  Ser Val Gly Ser Asp  Asp Glu Leu Gly Pro  Ile Arg Lys 
    1175                 1180                 1185             


Lys Glu  Glu Asp Gln Ala Ser  Gln Gly Tyr Lys Gly  Asp Asn Ala 
    1190                 1195                 1200             


Val Ile  Pro Tyr Glu Thr Asp  Glu Asp Pro Arg Arg  Arg Asn Ile 
    1205                 1210                 1215             


Leu Arg  Ser Leu Arg Arg Asn  Thr Lys Lys Pro Lys  Pro Lys Pro 
    1220                 1225                 1230             


Arg Pro  Ser Ile Thr Lys Ala  Thr Trp Glu Ser Asn  Tyr Phe Gly 
    1235                 1240                 1245             


Val Pro  Leu Thr Thr Val Val  Thr Pro Glu Lys Pro  Ile Pro Ile 
    1250                 1255                 1260             


Phe Ile  Glu Arg Cys Ile Glu  Tyr Ile Glu Ala Thr  Gly Leu Ser 
    1265                 1270                 1275             


Thr Glu  Gly Ile Tyr Arg Val  Ser Gly Asn Lys Ser  Glu Met Glu 
    1280                 1285                 1290             


Ser Leu  Gln Arg Gln Phe Asp  Gln Asp His Asn Leu  Asp Leu Ala 
    1295                 1300                 1305             


Glu Lys  Asp Phe Thr Val Asn  Thr Val Ala Gly Ala  Met Lys Ser 
    1310                 1315                 1320             


Phe Phe  Ser Glu Leu Pro Asp  Pro Leu Val Pro Tyr  Asn Met Gln 
    1325                 1330                 1335             


Ile Asp  Leu Val Glu Ala His  Lys Ile Asn Asp Arg  Glu Gln Lys 
    1340                 1345                 1350             


Leu His  Ala Leu Lys Glu Val  Leu Lys Lys Phe Pro  Lys Glu Asn 
    1355                 1360                 1365             


His Glu  Val Phe Lys Tyr Val  Ile Ser His Leu Asn  Lys Val Ser 
    1370                 1375                 1380             


His Asn  Asn Lys Val Asn Leu  Met Thr Ser Glu Asn  Leu Ser Ile 
    1385                 1390                 1395             


Cys Phe  Trp Pro Thr Leu Met  Arg Pro Asp Phe Ser  Thr Met Asp 
    1400                 1405                 1410             


Ala Leu  Thr Ala Thr Arg Thr  Tyr Gln Thr Ile Ile  Glu Leu Phe 
    1415                 1420                 1425             


Ile Gln  Gln Cys Pro Phe Phe  Phe Tyr Asn Arg Pro  Ile Thr Glu 
    1430                 1435                 1440             


Pro Pro  Gly Ala Arg Pro Ser  Ser Pro Ser Ala Val  Ala Ser Thr 
    1445                 1450                 1455             


Val Pro  Phe Leu Thr Ser Thr  Pro Val Thr Ser Gln  Pro Ser Pro 
    1460                 1465                 1470             


Pro Gln  Ser Pro Pro Pro Thr  Pro Gln Ser Pro Met  Gln Pro Leu 
    1475                 1480                 1485             


Leu Pro  Ser Gln Leu Gln Ala  Glu His Thr Leu 
    1490                 1495                 


<210>  724
<211>  874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP42__Homo_sapiens__NP_689645

<400>  724

Met Gly Leu Pro Thr Leu Glu Phe Ser Asp Ser Tyr Leu Asp Ser Pro 
1               5                   10                  15      


Asp Phe Arg Glu Arg Leu Gln Cys His Glu Ile Glu Leu Glu Arg Thr 
            20                  25                  30          


Asn Lys Phe Ile Lys Glu Leu Ile Lys Asp Gly Ser Leu Leu Ile Gly 
        35                  40                  45              


Ala Leu Arg Asn Leu Ser Met Ala Val Gln Lys Phe Ser Gln Ser Leu 
    50                  55                  60                  


Gln Asp Phe Gln Phe Glu Cys Ile Gly Asp Ala Glu Thr Asp Asp Glu 
65                  70                  75                  80  


Ile Ser Ile Ala Gln Ser Leu Lys Glu Phe Ala Arg Leu Leu Ile Ala 
                85                  90                  95      


Val Glu Glu Glu Arg Arg Arg Leu Ile Gln Asn Ala Asn Asp Val Leu 
            100                 105                 110         


Ile Ala Pro Leu Glu Lys Phe Arg Lys Glu Gln Ile Gly Ala Ala Lys 
        115                 120                 125             


Asp Gly Lys Lys Lys Phe Asp Lys Glu Ser Glu Lys Tyr Tyr Ser Ile 
    130                 135                 140                 


Leu Glu Lys His Leu Asn Leu Ser Ala Lys Lys Lys Glu Ser His Leu 
145                 150                 155                 160 


Gln Glu Ala Asp Thr Gln Ile Asp Arg Glu His Gln Asn Phe Tyr Glu 
                165                 170                 175     


Ala Ser Leu Glu Tyr Val Phe Lys Ile Gln Glu Val Gln Glu Lys Lys 
            180                 185                 190         


Lys Phe Glu Phe Val Glu Pro Leu Leu Ser Phe Leu Gln Gly Leu Phe 
        195                 200                 205             


Thr Phe Tyr His Glu Gly Tyr Glu Leu Ala Gln Glu Phe Ala Pro Tyr 
    210                 215                 220                 


Lys Gln Gln Leu Gln Phe Asn Leu Gln Asn Thr Arg Asn Asn Phe Glu 
225                 230                 235                 240 


Ser Thr Arg Gln Glu Val Glu Arg Leu Met Gln Arg Met Lys Ser Ala 
                245                 250                 255     


Asn Gln Asp Tyr Arg Pro Pro Ser Gln Trp Thr Met Glu Gly Tyr Leu 
            260                 265                 270         


Tyr Val Gln Glu Lys Arg Pro Leu Gly Phe Thr Trp Ile Lys His Tyr 
        275                 280                 285             


Cys Thr Tyr Asp Lys Gly Ser Lys Thr Phe Thr Met Ser Val Ser Glu 
    290                 295                 300                 


Met Lys Ser Ser Gly Lys Met Asn Gly Leu Val Thr Ser Ser Pro Glu 
305                 310                 315                 320 


Met Phe Lys Leu Lys Ser Cys Ile Arg Arg Lys Thr Asp Ser Ile Asp 
                325                 330                 335     


Lys Arg Phe Cys Phe Asp Ile Glu Val Val Glu Arg His Gly Ile Ile 
            340                 345                 350         


Thr Leu Gln Ala Phe Ser Glu Ala Asn Arg Lys Leu Trp Leu Glu Ala 
        355                 360                 365             


Met Asp Gly Lys Glu Pro Ile Tyr Thr Leu Pro Ala Ile Ile Ser Lys 
    370                 375                 380                 


Lys Glu Glu Met Tyr Leu Asn Glu Ala Gly Phe Asn Phe Val Arg Lys 
385                 390                 395                 400 


Cys Ile Gln Ala Val Glu Thr Arg Gly Ile Thr Ile Leu Gly Leu Tyr 
                405                 410                 415     


Arg Ile Gly Gly Val Asn Ser Lys Val Gln Lys Leu Met Asn Thr Thr 
            420                 425                 430         


Phe Ser Pro Lys Ser Pro Pro Asp Ile Asp Ile Asp Ile Glu Leu Trp 
        435                 440                 445             


Asp Asn Lys Thr Ile Thr Ser Gly Leu Lys Asn Tyr Leu Arg Cys Leu 
    450                 455                 460                 


Ala Glu Pro Leu Met Thr Tyr Lys Leu His Lys Asp Phe Ile Ile Ala 
465                 470                 475                 480 


Val Lys Ser Asp Asp Gln Asn Tyr Arg Val Glu Ala Val His Ala Leu 
                485                 490                 495     


Val His Lys Leu Pro Glu Lys Asn Arg Glu Met Leu Asp Ile Leu Ile 
            500                 505                 510         


Lys His Leu Val Lys Val Ser Leu His Ser Gln Gln Asn Leu Met Thr 
        515                 520                 525             


Val Ser Asn Leu Gly Val Ile Phe Gly Pro Thr Leu Met Arg Ala Gln 
    530                 535                 540                 


Glu Glu Thr Val Ala Ala Met Met Asn Ile Lys Phe Gln Asn Ile Val 
545                 550                 555                 560 


Val Glu Ile Leu Ile Glu His Tyr Glu Lys Ile Phe His Thr Ala Pro 
                565                 570                 575     


Asp Pro Ser Ile Pro Leu Pro Gln Pro Gln Ser Arg Ser Gly Ser Arg 
            580                 585                 590         


Arg Thr Arg Ala Ile Cys Leu Ser Thr Gly Ser Arg Lys Pro Arg Gly 
        595                 600                 605             


Arg Tyr Thr Pro Cys Leu Ala Glu Pro Asp Ser Asp Ser Tyr Ser Ser 
    610                 615                 620                 


Ser Pro Asp Ser Thr Pro Met Gly Ser Ile Glu Ser Leu Ser Ser His 
625                 630                 635                 640 


Ser Ser Glu Gln Asn Ser Thr Thr Lys Ser Ala Ser Cys Gln Pro Arg 
                645                 650                 655     


Glu Lys Ser Gly Gly Ile Pro Trp Ile Ala Thr Pro Ser Ser Ser Asn 
            660                 665                 670         


Gly Gln Lys Ser Leu Gly Leu Trp Thr Thr Ser Pro Glu Ser Ser Ser 
        675                 680                 685             


Arg Glu Asp Ala Thr Lys Thr Asp Ala Glu Ser Asp Cys Gln Ser Val 
    690                 695                 700                 


Ala Ser Val Thr Ser Pro Gly Asp Val Ser Pro Pro Ile Asp Leu Val 
705                 710                 715                 720 


Lys Lys Glu Pro Tyr Gly Leu Ser Gly Leu Lys Arg Ala Ser Ala Ser 
                725                 730                 735     


Ser Leu Arg Ser Ile Ser Ala Ala Glu Gly Asn Lys Ser Tyr Ser Gly 
            740                 745                 750         


Ser Ile Gln Ser Leu Thr Ser Val Gly Ser Lys Glu Thr Pro Lys Ala 
        755                 760                 765             


Ser Pro Asn Pro Asp Leu Pro Pro Lys Met Cys Arg Arg Leu Arg Leu 
    770                 775                 780                 


Asp Thr Ala Ser Ser Asn Gly Tyr Gln Arg Pro Gly Ser Val Val Ala 
785                 790                 795                 800 


Ala Lys Ala Gln Leu Phe Glu Asn Val Gly Ser Pro Lys Pro Val Ser 
                805                 810                 815     


Ser Gly Arg Gln Ala Lys Ala Met Tyr Ser Cys Lys Ala Glu His Ser 
            820                 825                 830         


His Glu Leu Ser Phe Pro Gln Gly Ala Ile Phe Ser Asn Val Tyr Pro 
        835                 840                 845             


Ser Val Glu Pro Gly Trp Leu Lys Ala Thr Tyr Glu Gly Lys Thr Gly 
    850                 855                 860                 


Leu Val Pro Glu Asn Tyr Val Val Phe Leu 
865                 870                 


<210>  725
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP4__Homo_sapiens__NP_001158213

<400>  725

Met Ala Ala His Gly Lys Leu Arg Arg Glu Arg Gly Leu Gln Ala Glu 
1               5                   10                  15      


Tyr Glu Thr Gln Val Lys Glu Met Arg Trp Gln Leu Ser Glu Gln Leu 
            20                  25                  30          


Arg Cys Leu Glu Leu Gln Gly Glu Leu Arg Arg Glu Leu Leu Gln Glu 
        35                  40                  45              


Leu Ala Glu Phe Met Arg Arg Arg Ala Glu Val Glu Leu Glu Tyr Ser 
    50                  55                  60                  


Arg Gly Leu Glu Lys Leu Ala Glu Arg Phe Ser Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Leu Gly Ser Ser Arg Glu His Gln Ser Phe Arg Lys Glu Pro Ser Leu 
                85                  90                  95      


Leu Ser Pro Leu His Cys Trp Ala Val Leu Leu Gln His Thr Arg Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Ala Ala Leu Ser Glu Val Leu Ala Gly Pro Leu 
        115                 120                 125             


Ala Gln Arg Leu Ser His Ile Ala Glu Asp Val Gly Arg Leu Val Lys 
    130                 135                 140                 


Lys Ser Arg Asp Leu Glu Gln Gln Leu Gln Asp Glu Leu Leu Glu Val 
145                 150                 155                 160 


Val Ser Glu Leu Gln Thr Ala Lys Lys Thr Tyr Gln Ala Tyr His Met 
                165                 170                 175     


Glu Ser Val Asn Ala Glu Ala Lys Leu Arg Glu Ala Glu Arg Gln Glu 
            180                 185                 190         


Glu Lys Arg Ala Gly Arg Ser Val Pro Thr Thr Thr Ala Gly Ala Thr 
        195                 200                 205             


Glu Ala Gly Pro Leu Arg Lys Ser Ser Leu Lys Lys Gly Gly Arg Leu 
    210                 215                 220                 


Val Glu Lys Leu Trp Pro Pro Gln Arg Pro Val Ala Ala Ser Ser Cys 
225                 230                 235                 240 


Ala Pro Val Cys Trp Leu Gln Ala Gly Phe Leu Val His Pro Pro Trp 
                245                 250                 255     


Trp Gly Ala Met Cys Ala Pro Ser Thr His Gln Arg Gln Ala Lys Phe 
            260                 265                 270         


Met Glu His Lys Leu Lys Cys Thr Lys Ala Arg Asn Glu Tyr Leu Leu 
        275                 280                 285             


Ser Leu Ala Ser Val Asn Ala Ala Val Ser Asn Tyr Tyr Leu His Asp 
    290                 295                 300                 


Val Leu Asp Leu Met Asp Cys Cys Asp Thr Gly Phe His Leu Ala Leu 
305                 310                 315                 320 


Gly Gln Val Leu Arg Ser Tyr Thr Ala Ala Glu Ser Arg Thr Gln Ala 
                325                 330                 335     


Ser Gln Val Gln Gly Leu Gly Ser Leu Glu Glu Ala Val Glu Ala Leu 
            340                 345                 350         


Asp Pro Pro Gly Asp Lys Ala Lys Val Leu Glu Val His Ala Thr Val 
        355                 360                 365             


Phe Cys Pro Pro Leu Arg Phe Asp Tyr His Pro His Asp Gly Asp Glu 
    370                 375                 380                 


Val Ala Glu Ile Cys Val Glu Met Glu Leu Arg Asp Glu Ile Leu Pro 
385                 390                 395                 400 


Arg Ala Gln Asn Ile Gln Ser Arg Leu Asp Arg Gln Thr Ile Glu Thr 
                405                 410                 415     


Glu Glu Val Asn Lys Thr Leu Lys Ala Thr Leu Gln Ala Leu Leu Glu 
            420                 425                 430         


Val Val Ala Ser Asp Asp Gly Asp Val Leu Asp Ser Phe Gln Thr Ser 
        435                 440                 445             


Pro Ser Thr Glu Ser Leu Lys Ser Thr Ser Ser Asp Pro Gly Ser Arg 
    450                 455                 460                 


Gln Ala Gly Arg Arg Arg Gly Gln Gln Gln Glu Thr Glu Thr Phe Tyr 
465                 470                 475                 480 


Leu Thr Lys Leu Gln Glu Tyr Leu Ser Gly Arg Ser Ile Leu Ala Lys 
                485                 490                 495     


Leu Gln Ala Lys His Glu Lys Leu Gln Glu Ala Leu Gln Arg Gly Asp 
            500                 505                 510         


Lys Glu Glu Gln Glu Val Ser Trp Thr Gln Tyr Thr Gln Arg Lys Phe 
        515                 520                 525             


Gln Lys Ser Arg Gln Pro Arg Pro Ser Ser Gln Tyr Asn Gln Arg Leu 
    530                 535                 540                 


Phe Gly Gly Asp Met Glu Lys Phe Ile Gln Ser Ser Gly Gln Pro Val 
545                 550                 555                 560 


Pro Leu Val Val Glu Ser Cys Ile Arg Phe Ile Asn Leu Asn Gly Leu 
                565                 570                 575     


Gln His Glu Gly Ile Phe Arg Val Ser Gly Ala Gln Leu Arg Val Ser 
            580                 585                 590         


Glu Ile Arg Asp Ala Phe Glu Arg Gly Glu Asp Pro Leu Val Glu Gly 
        595                 600                 605             


Cys Thr Ala His Asp Leu Asp Ser Val Ala Gly Val Leu Lys Leu Tyr 
    610                 615                 620                 


Phe Arg Ser Leu Glu Pro Pro Leu Phe Pro Pro Asp Leu Phe Gly Glu 
625                 630                 635                 640 


Leu Leu Ala Ser Ser Glu Leu Glu Ala Thr Ala Glu Arg Val Glu His 
                645                 650                 655     


Val Ser Arg Leu Leu Trp Arg Leu Pro Ala Pro Val Leu Val Val Leu 
            660                 665                 670         


Arg Tyr Leu Phe Thr Phe Leu Asn His Leu Ala Gln Tyr Ser Asp Glu 
        675                 680                 685             


Asn Met Met Asp Pro Tyr Asn Leu Ala Val Cys Phe Gly Pro Thr Leu 
    690                 695                 700                 


Leu Pro Val Pro Ala Gly Gln Asp Pro Val Ala Leu Gln Gly Arg Val 
705                 710                 715                 720 


Asn Gln Leu Val Gln Thr Leu Ile Val Gln Pro Asp Arg Val Phe Pro 
                725                 730                 735     


Pro Leu Thr Ser Leu Pro Gly Pro Val Tyr Glu Lys Cys Met Ala Pro 
            740                 745                 750         


Pro Ser Ala Ser Cys Leu Gly Asp Ala Gln Leu Glu Ser Leu Gly Ala 
        755                 760                 765             


Asp Asn Glu Pro Glu Leu Glu Ala Glu Met Pro Ala Gln Glu Asp Asp 
    770                 775                 780                 


Leu Glu Gly Val Val Glu Ala Val Ala Cys Phe Ala Tyr Thr Gly Arg 
785                 790                 795                 800 


Thr Ala Gln Glu Leu Ser Phe Arg Arg Gly Asp Val Leu Arg Leu His 
                805                 810                 815     


Glu Arg Ala Ser Ser Asp Trp Trp Arg Gly Glu His Asn Gly Met Arg 
            820                 825                 830         


Gly Leu Ile Pro His Lys Tyr Ile Thr Leu Pro Ala Gly Thr Glu Lys 
        835                 840                 845             


Gln Val Val Gly Ala Gly Leu Gln Thr Ala Gly Glu Ser Gly Ser Ser 
    850                 855                 860                 


Pro Glu Gly Leu Leu Ala Ser Glu Leu Val His Arg Pro Glu Pro Cys 
865                 870                 875                 880 


Thr Ser Pro Glu Ala Met Gly Pro Ser Gly His Arg Arg Arg Cys Leu 
                885                 890                 895     


Val Pro Ala Ser Pro Glu Gln His Val Glu Val Asp Lys Ala Val Ala 
            900                 905                 910         


Gln Asn Met Asp Ser Val Phe Lys Glu Leu Leu Gly Lys Thr Ser Val 
        915                 920                 925             


Arg Gln Gly Leu Gly Pro Ala Ser Thr Thr Ser Pro Ser Pro Gly Pro 
    930                 935                 940                 


Arg Ser Pro Lys Ala Pro Pro Ser Ser Arg Leu Gly Arg Asn Lys Gly 
945                 950                 955                 960 


Phe Ser Arg Gly Pro Gly Ala Pro Ala Ser Pro Ser Ala Ser His Pro 
                965                 970                 975     


Gln Gly Leu Asp Thr Thr Pro Lys Pro His 
            980                 985     


<210>  726
<211>  1501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP5__Homo_sapiens__NP_001164

<400>  726

Met Met Ala Lys Asn Lys Glu Pro Arg Pro Pro Ser Tyr Thr Ile Ser 
1               5                   10                  15      


Ile Val Gly Leu Ser Gly Thr Glu Lys Asp Lys Gly Asn Cys Gly Val 
            20                  25                  30          


Gly Lys Ser Cys Leu Cys Asn Arg Phe Val Arg Ser Lys Ala Asp Glu 
        35                  40                  45              


Tyr Tyr Pro Glu His Thr Ser Val Leu Ser Thr Ile Asp Phe Gly Gly 
    50                  55                  60                  


Arg Val Val Asn Asn Asp His Phe Leu Tyr Trp Gly Asp Ile Ile Gln 
65                  70                  75                  80  


Asn Ser Glu Asp Gly Val Glu Cys Lys Ile His Val Ile Glu Gln Thr 
                85                  90                  95      


Glu Phe Ile Asp Asp Gln Thr Phe Leu Pro His Arg Ser Thr Asn Leu 
            100                 105                 110         


Gln Pro Tyr Ile Lys Arg Ala Ala Ala Ser Lys Leu Gln Ser Ala Glu 
        115                 120                 125             


Lys Leu Met Tyr Ile Cys Thr Asp Gln Leu Gly Leu Glu Gln Asp Phe 
    130                 135                 140                 


Glu Gln Lys Gln Met Pro Glu Gly Lys Leu Asn Val Asp Gly Phe Leu 
145                 150                 155                 160 


Leu Cys Ile Asp Val Ser Gln Gly Cys Asn Arg Lys Phe Asp Asp Gln 
                165                 170                 175     


Leu Lys Phe Val Asn Asn Leu Phe Val Gln Leu Ser Lys Ser Lys Lys 
            180                 185                 190         


Pro Val Ile Ile Ala Ala Thr Lys Cys Asp Glu Cys Val Asp His Tyr 
        195                 200                 205             


Leu Arg Glu Val Gln Ala Phe Ala Ser Asn Lys Lys Asn Leu Leu Val 
    210                 215                 220                 


Val Glu Thr Ser Ala Arg Phe Asn Val Asn Ile Glu Thr Cys Phe Thr 
225                 230                 235                 240 


Ala Leu Val Gln Met Leu Asp Lys Thr Arg Ser Lys Pro Lys Ile Ile 
                245                 250                 255     


Pro Tyr Leu Asp Ala Tyr Lys Thr Gln Arg Gln Leu Val Val Thr Ala 
            260                 265                 270         


Thr Asp Lys Phe Glu Lys Leu Val Gln Thr Val Arg Asp Tyr His Ala 
        275                 280                 285             


Thr Trp Lys Thr Val Ser Asn Lys Leu Lys Asn His Pro Asp Tyr Glu 
    290                 295                 300                 


Glu Tyr Ile Asn Leu Glu Gly Thr Arg Lys Ala Arg Asn Thr Phe Ser 
305                 310                 315                 320 


Lys His Ile Glu Gln Leu Lys Gln Glu His Ile Arg Lys Arg Arg Glu 
                325                 330                 335     


Glu Tyr Ile Asn Thr Leu Pro Arg Ala Phe Asn Thr Leu Leu Pro Asn 
            340                 345                 350         


Leu Glu Glu Ile Glu His Leu Asn Trp Ser Glu Ala Leu Lys Leu Met 
        355                 360                 365             


Glu Lys Arg Ala Asp Phe Gln Leu Cys Phe Val Val Leu Glu Lys Thr 
    370                 375                 380                 


Pro Trp Asp Glu Thr Asp His Ile Asp Lys Ile Asn Asp Arg Arg Ile 
385                 390                 395                 400 


Pro Phe Asp Leu Leu Ser Thr Leu Glu Ala Glu Lys Val Tyr Gln Asn 
                405                 410                 415     


His Val Gln His Leu Ile Ser Glu Lys Arg Arg Val Glu Met Lys Glu 
            420                 425                 430         


Lys Phe Lys Lys Thr Leu Glu Lys Ile Gln Phe Ile Ser Pro Gly Gln 
        435                 440                 445             


Pro Trp Glu Glu Val Met Cys Phe Val Met Glu Asp Glu Ala Tyr Lys 
    450                 455                 460                 


Tyr Ile Thr Glu Ala Asp Ser Lys Glu Val Tyr Gly Arg His Gln Arg 
465                 470                 475                 480 


Glu Ile Val Glu Lys Ala Lys Glu Glu Phe Gln Glu Met Leu Phe Glu 
                485                 490                 495     


His Ser Glu Leu Phe Tyr Asp Leu Asp Leu Asn Ala Thr Pro Ser Ser 
            500                 505                 510         


Asp Lys Met Ser Glu Ile His Thr Val Leu Ser Glu Glu Pro Arg Tyr 
        515                 520                 525             


Lys Ala Leu Gln Lys Leu Ala Pro Asp Arg Glu Ser Leu Leu Leu Lys 
    530                 535                 540                 


His Ile Gly Phe Val Tyr His Pro Thr Lys Glu Thr Cys Leu Ser Gly 
545                 550                 555                 560 


Gln Asn Cys Thr Asp Ile Lys Val Glu Gln Leu Leu Ala Ser Ser Leu 
                565                 570                 575     


Leu Gln Leu Asp His Gly Arg Leu Arg Leu Tyr His Asp Ser Thr Asn 
            580                 585                 590         


Ile Asp Lys Val Asn Leu Phe Ile Leu Gly Lys Asp Gly Leu Ala Gln 
        595                 600                 605             


Glu Leu Ala Asn Glu Ile Arg Thr Gln Ser Thr Asp Asp Glu Tyr Ala 
    610                 615                 620                 


Leu Asp Gly Lys Ile Tyr Glu Leu Asp Leu Arg Pro Val Asp Ala Lys 
625                 630                 635                 640 


Ser Pro Tyr Phe Leu Ser Gln Leu Trp Thr Ala Ala Phe Lys Pro His 
                645                 650                 655     


Gly Cys Phe Cys Val Phe Asn Ser Ile Glu Ser Leu Ser Phe Ile Gly 
            660                 665                 670         


Glu Phe Ile Gly Lys Ile Arg Thr Glu Ala Ser Gln Ile Arg Lys Asp 
        675                 680                 685             


Lys Tyr Met Ala Asn Leu Pro Phe Thr Leu Ile Leu Ala Asn Gln Arg 
    690                 695                 700                 


Asp Ser Ile Ser Lys Asn Leu Pro Ile Leu Arg His Gln Gly Gln Gln 
705                 710                 715                 720 


Leu Ala Asn Lys Leu Gln Cys Pro Phe Val Asp Val Pro Ala Gly Thr 
                725                 730                 735     


Tyr Pro Arg Lys Phe Asn Glu Thr Gln Ile Lys Gln Ala Leu Arg Gly 
            740                 745                 750         


Val Leu Glu Ser Val Lys His Asn Leu Asp Val Val Ser Pro Ile Pro 
        755                 760                 765             


Ala Asn Lys Asp Leu Ser Glu Ala Asp Leu Arg Ile Val Met Cys Ala 
    770                 775                 780                 


Met Cys Gly Asp Pro Phe Ser Val Asp Leu Ile Leu Ser Pro Phe Leu 
785                 790                 795                 800 


Asp Ser His Ser Cys Ser Ala Ala Gln Ala Gly Gln Asn Asn Ser Leu 
                805                 810                 815     


Met Leu Asp Lys Ile Ile Gly Glu Lys Arg Arg Arg Ile Gln Ile Thr 
            820                 825                 830         


Ile Leu Ser Tyr His Ser Ser Ile Gly Val Arg Lys Asp Glu Leu Val 
        835                 840                 845             


His Gly Tyr Ile Leu Val Tyr Ser Ala Lys Arg Lys Ala Ser Met Gly 
    850                 855                 860                 


Met Leu Arg Ala Phe Leu Ser Glu Val Gln Asp Thr Ile Pro Val Gln 
865                 870                 875                 880 


Leu Val Ala Val Thr Asp Ser Gln Ala Asp Phe Phe Glu Asn Glu Ala 
                885                 890                 895     


Ile Lys Glu Leu Met Thr Glu Gly Glu His Ile Ala Thr Glu Ile Thr 
            900                 905                 910         


Ala Lys Phe Thr Ala Leu Tyr Ser Leu Ser Gln Tyr His Arg Gln Thr 
        915                 920                 925             


Glu Val Phe Thr Leu Phe Phe Ser Asp Val Leu Glu Lys Lys Asn Met 
    930                 935                 940                 


Ile Glu Asn Ser Tyr Leu Ser Asp Asn Thr Arg Glu Ser Thr His Gln 
945                 950                 955                 960 


Ser Glu Asp Val Phe Leu Pro Ser Pro Arg Asp Cys Phe Pro Tyr Asn 
                965                 970                 975     


Asn Tyr Pro Asp Ser Asp Asp Asp Thr Glu Ala Pro Pro Pro Tyr Ser 
            980                 985                 990         


Pro Ile Gly Asp Asp Val Gln Leu  Leu Pro Thr Pro Ser  Asp Arg Ser 
        995                 1000                 1005             


Arg Tyr  Arg Leu Asp Leu Glu  Gly Asn Glu Tyr Pro  Ile His Ser 
    1010                 1015                 1020             


Thr Pro  Asn Cys His Asp His  Glu Arg Asn His Lys  Val Pro Pro 
    1025                 1030                 1035             


Pro Ile  Lys Pro Lys Pro Val  Val Pro Lys Thr Asn  Val Lys Lys 
    1040                 1045                 1050             


Leu Asp  Pro Asn Leu Leu Lys  Thr Ile Glu Ala Gly  Ile Gly Lys 
    1055                 1060                 1065             


Asn Pro  Arg Lys Gln Thr Ser  Arg Val Pro Leu Ala  His Pro Glu 
    1070                 1075                 1080             


Asp Met  Asp Pro Ser Asp Asn  Tyr Ala Glu Pro Ile  Asp Thr Ile 
    1085                 1090                 1095             


Phe Lys  Gln Lys Gly Tyr Ser  Asp Glu Ile Tyr Val  Val Pro Asp 
    1100                 1105                 1110             


Asp Ser  Gln Asn Arg Ile Lys  Ile Arg Asn Ser Phe  Val Asn Asn 
    1115                 1120                 1125             


Thr Gln  Gly Asp Glu Glu Asn  Gly Phe Ser Asp Arg  Thr Ser Lys 
    1130                 1135                 1140             


Ser His  Gly Glu Arg Arg Pro  Ser Lys Tyr Lys Tyr  Lys Ser Lys 
    1145                 1150                 1155             


Thr Leu  Phe Ser Lys Ala Lys  Ser Tyr Tyr Arg Arg  Thr His Ser 
    1160                 1165                 1170             


Asp Ala  Ser Asp Asp Glu Ala  Phe Thr Thr Ser Lys  Thr Lys Arg 
    1175                 1180                 1185             


Lys Gly  Arg His Arg Gly Ser  Glu Glu Asp Pro Leu  Leu Ser Pro 
    1190                 1195                 1200             


Val Glu  Thr Trp Lys Gly Gly  Ile Asp Asn Pro Ala  Ile Thr Ser 
    1205                 1210                 1215             


Asp Gln  Glu Leu Asp Asp Lys  Lys Met Lys Lys Lys  Thr His Lys 
    1220                 1225                 1230             


Val Lys  Glu Asp Lys Lys Lys  Lys Lys Thr Lys Asn  Phe Asn Pro 
    1235                 1240                 1245             


Pro Thr  Arg Arg Asn Trp Glu  Ser Asn Tyr Phe Gly  Met Pro Leu 
    1250                 1255                 1260             


Gln Asp  Leu Val Thr Ala Glu  Lys Pro Ile Pro Leu  Phe Val Glu 
    1265                 1270                 1275             


Lys Cys  Val Glu Phe Ile Glu  Asp Thr Gly Leu Cys  Thr Glu Gly 
    1280                 1285                 1290             


Leu Tyr  Arg Val Ser Gly Asn  Lys Thr Asp Gln Asp  Asn Ile Gln 
    1295                 1300                 1305             


Lys Gln  Phe Asp Gln Asp His  Asn Ile Asn Leu Val  Ser Met Glu 
    1310                 1315                 1320             


Val Thr  Val Asn Ala Val Ala  Gly Ala Leu Lys Ala  Phe Phe Ala 
    1325                 1330                 1335             


Asp Leu  Pro Asp Pro Leu Ile  Pro Tyr Ser Leu His  Pro Glu Leu 
    1340                 1345                 1350             


Leu Glu  Ala Ala Lys Ile Pro  Asp Lys Thr Glu Arg  Leu His Ala 
    1355                 1360                 1365             


Leu Lys  Glu Ile Val Lys Lys  Phe His Pro Val Asn  Tyr Asp Val 
    1370                 1375                 1380             


Phe Arg  Tyr Val Ile Thr His  Leu Asn Arg Val Ser  Gln Gln His 
    1385                 1390                 1395             


Lys Ile  Asn Leu Met Thr Ala  Asp Asn Leu Ser Ile  Cys Phe Trp 
    1400                 1405                 1410             


Pro Thr  Leu Met Arg Pro Asp  Phe Glu Asn Arg Glu  Phe Leu Ser 
    1415                 1420                 1425             


Thr Thr  Lys Ile His Gln Ser  Val Val Glu Thr Phe  Ile Gln Gln 
    1430                 1435                 1440             


Cys Gln  Phe Phe Phe Tyr Asn  Gly Glu Ile Val Glu  Thr Thr Asn 
    1445                 1450                 1455             


Ile Val  Ala Pro Pro Pro Pro  Ser Asn Pro Gly Gln  Leu Val Glu 
    1460                 1465                 1470             


Pro Met  Val Pro Leu Gln Leu  Pro Pro Pro Leu Gln  Pro Gln Leu 
    1475                 1480                 1485             


Ile Gln  Pro Gln Leu Gln Thr  Asp Pro Leu Gly Ile  Ile 
    1490                 1495                 1500     


<210>  727
<211>  794
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP6__Homo_sapiens__NP_001274171

<400>  727

Met Gly His Pro Val Tyr Arg Gly Glu Lys Pro Gln Leu His Tyr Ala 
1               5                   10                  15      


Gly Asp Phe Thr Trp Asn Ser Met Ser Gly Arg Ser Val Arg Leu Arg 
            20                  25                  30          


Ser Val Pro Ile Gln Ser Leu Ser Glu Leu Glu Arg Ala Arg Leu Gln 
        35                  40                  45              


Glu Val Ala Phe Tyr Gln Leu Gln Gln Asp Cys Asp Leu Ser Cys Gln 
    50                  55                  60                  


Ile Thr Ile Pro Lys Asp Gly Gln Lys Arg Lys Lys Ser Leu Arg Lys 
65                  70                  75                  80  


Lys Leu Asp Ser Leu Gly Lys Glu Lys Asn Lys Asp Lys Glu Phe Ile 
                85                  90                  95      


Pro Gln Ala Phe Gly Met Pro Leu Ser Gln Val Ile Ala Asn Asp Arg 
            100                 105                 110         


Ala Tyr Lys Leu Lys Gln Asp Leu Gln Arg Asp Glu Gln Lys Asp Ala 
        115                 120                 125             


Ser Asp Phe Val Ala Ser Leu Leu Pro Phe Gly Asn Lys Arg Gln Asn 
    130                 135                 140                 


Lys Glu Leu Ser Ser Ser Asn Ser Ser Leu Ser Ser Thr Ser Glu Thr 
145                 150                 155                 160 


Pro Asn Glu Ser Thr Ser Pro Asn Thr Pro Glu Pro Ala Pro Arg Ala 
                165                 170                 175     


Arg Arg Arg Gly Ala Met Ser Val Asp Ser Ile Thr Asp Leu Asp Asp 
            180                 185                 190         


Asn Gln Ser Arg Leu Leu Glu Ala Leu Gln Leu Ser Leu Pro Ala Glu 
        195                 200                 205             


Ala Gln Ser Lys Lys Glu Lys Ala Arg Asp Lys Lys Leu Ser Leu Asn 
    210                 215                 220                 


Pro Ile Tyr Arg Gln Val Pro Arg Leu Val Asp Ser Cys Cys Gln His 
225                 230                 235                 240 


Leu Glu Lys His Gly Leu Gln Thr Val Gly Ile Phe Arg Val Gly Ser 
                245                 250                 255     


Ser Lys Lys Arg Val Arg Gln Leu Arg Glu Glu Phe Asp Arg Gly Ile 
            260                 265                 270         


Asp Val Ser Leu Glu Glu Glu His Ser Val His Asp Val Ala Ala Leu 
        275                 280                 285             


Leu Lys Glu Phe Leu Arg Asp Met Pro Asp Pro Leu Leu Thr Arg Glu 
    290                 295                 300                 


Leu Tyr Thr Ala Phe Ile Asn Thr Leu Leu Leu Glu Pro Glu Glu Gln 
305                 310                 315                 320 


Leu Gly Thr Leu Gln Leu Leu Ile Tyr Leu Leu Pro Pro Cys Asn Cys 
                325                 330                 335     


Asp Thr Leu His Arg Leu Leu Gln Phe Leu Ser Ile Val Ala Arg His 
            340                 345                 350         


Ala Asp Asp Asn Ile Ser Lys Asp Gly Gln Glu Val Thr Gly Asn Lys 
        355                 360                 365             


Met Thr Ser Leu Asn Leu Ala Thr Ile Phe Gly Pro Asn Leu Leu His 
    370                 375                 380                 


Lys Gln Lys Ser Ser Asp Lys Glu Phe Ser Val Gln Ser Ser Ala Arg 
385                 390                 395                 400 


Ala Glu Glu Ser Thr Ala Ile Ile Ala Val Val Gln Lys Met Ile Glu 
                405                 410                 415     


Asn Tyr Glu Ala Leu Phe Met Val Pro Pro Asp Leu Gln Asn Glu Val 
            420                 425                 430         


Leu Ile Ser Leu Leu Glu Thr Asp Pro Asp Val Val Asp Tyr Leu Leu 
        435                 440                 445             


Arg Arg Lys Ala Ser Gln Ser Ser Ser Pro Asp Met Leu Gln Ser Glu 
    450                 455                 460                 


Val Ser Phe Ser Val Gly Gly Arg His Ser Ser Thr Asp Ser Asn Lys 
465                 470                 475                 480 


Ala Ser Ser Gly Asp Ile Ser Pro Tyr Asp Asn Asn Ser Pro Val Leu 
                485                 490                 495     


Ser Glu Arg Ser Leu Leu Ala Met Gln Glu Asp Ala Ala Pro Gly Gly 
            500                 505                 510         


Ser Glu Lys Leu Tyr Arg Val Pro Gly Gln Phe Met Leu Val Gly His 
        515                 520                 525             


Leu Ser Ser Ser Lys Ser Arg Glu Ser Ser Pro Gly Pro Arg Leu Gly 
    530                 535                 540                 


Lys Asp Leu Ser Glu Glu Pro Phe Asp Ile Trp Gly Thr Trp His Ser 
545                 550                 555                 560 


Thr Leu Lys Ser Gly Ser Lys Asp Pro Gly Met Thr Gly Ser Ser Gly 
                565                 570                 575     


Asp Ile Phe Glu Ser Ser Ser Leu Arg Ala Gly Pro Cys Ser Leu Ser 
            580                 585                 590         


Gln Gly Asn Leu Ser Pro Asn Trp Pro Arg Trp Gln Gly Ser Pro Ala 
        595                 600                 605             


Glu Leu Asp Ser Asp Thr Gln Gly Ala Arg Arg Thr Gln Ala Ala Ala 
    610                 615                 620                 


Pro Ala Thr Glu Gly Arg Ala His Pro Ala Val Ser Arg Ala Cys Ser 
625                 630                 635                 640 


Thr Pro His Val Gln Val Ala Gly Lys Ala Glu Arg Pro Thr Ala Arg 
                645                 650                 655     


Ser Glu Gln Tyr Leu Thr Leu Ser Gly Ala His Asp Leu Ser Glu Ser 
            660                 665                 670         


Glu Leu Asp Val Ala Gly Leu Gln Ser Arg Ala Thr Pro Gln Cys Gln 
        675                 680                 685             


Arg Pro His Gly Ser Gly Arg Asp Asp Lys Arg Pro Pro Pro Pro Tyr 
    690                 695                 700                 


Pro Gly Pro Gly Lys Pro Ala Ala Ala Ala Ala Trp Ile Gln Gly Pro 
705                 710                 715                 720 


Pro Glu Gly Val Glu Thr Pro Thr Asp Gln Gly Gly Gln Ala Ala Glu 
                725                 730                 735     


Arg Glu Gln Gln Val Thr Gln Lys Lys Leu Ser Ser Ala Asn Ser Leu 
            740                 745                 750         


Pro Ala Gly Glu Gln Asp Ser Pro Arg Leu Gly Asp Ala Gly Trp Leu 
        755                 760                 765             


Asp Trp Gln Arg Glu Arg Trp Gln Ile Trp Glu Leu Leu Ser Thr Asp 
    770                 775                 780                 


Asn Pro Asp Ala Leu Pro Glu Thr Leu Val 
785                 790                 


<210>  728
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGAP9__Homo_sapiens__NP_001073625

<400>  728

Met Ser Glu Pro Pro Val Tyr Cys Asn Leu Val Asp Leu Arg Arg Cys 
1               5                   10                  15      


Pro Arg Ser Pro Pro Pro Gly Pro Ala Cys Pro Leu Leu Gln Arg Leu 
            20                  25                  30          


Asp Ala Trp Glu Gln His Leu Asp Pro Asn Ser Gly Arg Cys Phe Tyr 
        35                  40                  45              


Ile Asn Ser Leu Thr Gly Cys Lys Ser Trp Lys Pro Pro Arg Arg Ser 
    50                  55                  60                  


Arg Ser Glu Thr Asn Pro Gly Ser Met Glu Gly Thr Gln Thr Leu Lys 
65                  70                  75                  80  


Arg Asn Asn Asp Val Leu Gln Pro Gln Ala Lys Gly Phe Arg Ser Asp 
                85                  90                  95      


Thr Gly Thr Pro Glu Pro Leu Asp Pro Gln Gly Ser Leu Ser Leu Ser 
            100                 105                 110         


Gln Arg Thr Ser Gln Leu Asp Pro Pro Ala Leu Gln Ala Pro Arg Pro 
        115                 120                 125             


Leu Pro Gln Leu Leu Asp Asp Pro His Glu Val Glu Lys Ser Gly Leu 
    130                 135                 140                 


Leu Asn Met Thr Lys Ile Ala Gln Gly Gly Arg Lys Leu Arg Lys Asn 
145                 150                 155                 160 


Trp Gly Pro Ser Trp Val Val Leu Thr Gly Asn Ser Leu Val Phe Tyr 
                165                 170                 175     


Arg Glu Pro Pro Pro Thr Ala Pro Ser Ser Gly Trp Gly Pro Ala Gly 
            180                 185                 190         


Ser Arg Pro Glu Ser Ser Val Asp Leu Arg Gly Ala Ala Leu Ala His 
        195                 200                 205             


Gly Arg His Leu Ser Ser Arg Arg Asn Val Leu His Ile Arg Thr Ile 
    210                 215                 220                 


Pro Gly His Glu Phe Leu Leu Gln Ser Asp His Glu Thr Glu Leu Arg 
225                 230                 235                 240 


Ala Trp His Arg Ala Leu Arg Thr Val Ile Glu Arg Leu Asp Arg Glu 
                245                 250                 255     


Asn Pro Leu Glu Leu Arg Leu Ser Gly Ser Gly Pro Ala Glu Leu Ser 
            260                 265                 270         


Ala Gly Glu Asp Glu Glu Glu Glu Ser Glu Leu Val Ser Lys Pro Leu 
        275                 280                 285             


Leu Arg Leu Ser Ser Arg Arg Ser Ser Ile Arg Gly Pro Glu Gly Thr 
    290                 295                 300                 


Glu Gln Asn Arg Val Arg Asn Lys Leu Lys Arg Leu Ile Ala Lys Arg 
305                 310                 315                 320 


Pro Pro Leu Gln Ser Leu Gln Glu Arg Gly Leu Leu Arg Asp Gln Val 
                325                 330                 335     


Phe Gly Cys Gln Leu Glu Ser Leu Cys Gln Arg Glu Gly Asp Thr Val 
            340                 345                 350         


Pro Ser Phe Leu Arg Leu Cys Ile Ala Ala Val Asp Lys Arg Gly Leu 
        355                 360                 365             


Asp Val Asp Gly Ile Tyr Arg Val Ser Gly Asn Leu Ala Val Val Gln 
    370                 375                 380                 


Lys Leu Arg Phe Leu Val Asp Arg Glu Arg Ala Val Thr Ser Asp Gly 
385                 390                 395                 400 


Arg Tyr Val Phe Pro Glu Gln Pro Gly Gln Glu Gly Arg Leu Asp Leu 
                405                 410                 415     


Asp Ser Thr Glu Trp Asp Asp Ile His Val Val Thr Gly Ala Leu Lys 
            420                 425                 430         


Leu Phe Leu Arg Glu Leu Pro Gln Pro Leu Val Pro Pro Leu Leu Leu 
        435                 440                 445             


Pro His Phe Arg Ala Ala Leu Ala Leu Ser Glu Ser Glu Gln Cys Leu 
    450                 455                 460                 


Ser Gln Ile Gln Glu Leu Ile Gly Ser Met Pro Lys Pro Asn His Asp 
465                 470                 475                 480 


Thr Leu Arg Tyr Leu Leu Glu His Leu Cys Arg Val Ile Ala His Ser 
                485                 490                 495     


Asp Lys Asn Arg Met Thr Pro His Asn Leu Gly Ile Val Phe Gly Pro 
            500                 505                 510         


Thr Leu Phe Arg Pro Glu Gln Glu Thr Ser Asp Pro Ala Ala His Ala 
        515                 520                 525             


Leu Tyr Pro Gly Gln Leu Val Gln Leu Met Leu Thr Asn Phe Thr Ser 
    530                 535                 540                 


Leu Phe Pro 
545         


<210>  729
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGDIA__Homo_sapiens__NP_001288171

<400>  729

Met Ala Glu Gln Glu Pro Thr Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Thr Gly Leu Thr Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Thr Gly Asp Leu Glu Ser 
                85                  90                  95      


Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile 
            100                 105                 110         


Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr 
        115                 120                 125             


Ile Gln His Thr Tyr Arg Lys Gly Val Lys Ile Asp Lys Thr Asp Tyr 
    130                 135                 140                 


Met Thr Thr Thr Arg Pro Thr Thr Cys Pro Gly Ser Gly Ile Ser Pro 
145                 150                 155                 160 


Ser Arg Arg Thr Gly Arg Thr Glu Pro Ser Gln Arg Arg Ala Gly Gln 
                165                 170                 175     


Thr Asp Gly Arg Thr Thr Asp Arg Arg Met Cys Pro Pro Gln Pro Leu 
            180                 185                 190         


Pro Ser Pro Tyr Gln Ser Ala Asp Arg Pro Ser Val Pro Leu Pro Pro 
        195                 200                 205             


Trp Ser Ala Ser Leu Ala Trp Leu Asn Arg Val Pro Pro Thr Pro Leu 
    210                 215                 220                 


Leu Ser Pro Pro Pro Pro Thr Gly Pro Ala Ser Ser Val Ser Cys Leu 
225                 230                 235                 240 


Val Ala Ala Ser Ala Cys Ala Val Gly Glu Arg Gly Arg Ser Gln Ala 
                245                 250                 255     


Ser Ala Ala Leu Ser Val Pro Pro Arg Phe Tyr Leu Pro Val Thr Pro 
            260                 265                 270         


Glu Ala Trp Leu Gln Glu Gly Ala Glu Gln Pro Phe Ser Arg Pro Arg 
        275                 280                 285             


Gly Cys Pro Trp Thr Cys Ala Ser Ala Ala Pro Gly Trp Ser Trp Gly 
    290                 295                 300                 


Val Gly Cys Thr Ala Ser Trp Gly Pro Gly Arg Pro Pro Ala Pro Leu 
305                 310                 315                 320 


Leu Pro Gly Gln Pro Pro Cys Arg Cys Arg Ser Arg Leu Thr Met Met 
                325                 330                 335     


Pro 
    


<210>  730
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGDIB__Homo_sapiens__XP_011518968

<400>  730

Met Thr Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp 
1               5                   10                  15      


Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu 
            20                  25                  30          


Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr 
        35                  40                  45              


Lys Lys Thr Leu Leu Gly Asp Gly Pro Val Val Thr Asp Pro Lys Ala 
    50                  55                  60                  


Pro Asn Val Val Val Thr Arg Leu Thr Leu Val Cys Glu Ser Ala Pro 
65                  70                  75                  80  


Gly Pro Ile Thr Met Asp Leu Thr Gly Asp Leu Glu Ala Leu Lys Lys 
                85                  90                  95      


Glu Thr Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His 
            100                 105                 110         


Phe Lys Val Asn Arg Asp Ile Val Ser Gly Leu Lys Tyr Val Gln His 
        115                 120                 125             


Thr Tyr Arg Thr Gly Val Lys Val Asp Lys Ala Thr Phe Met Val Gly 
    130                 135                 140                 


Ser Tyr Gly Pro Arg Pro Glu Glu Tyr Glu Phe Leu Thr Pro Val Glu 
145                 150                 155                 160 


Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Thr Tyr His Asn Lys Ser 
                165                 170                 175     


Phe Phe Thr Asp Asp Asp Lys Gln Asp His Leu Ser Trp Glu Trp Asn 
            180                 185                 190         


Leu Ser Ile Lys Lys Glu Trp Thr Glu 
        195                 200     


<210>  731
<211>  1344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF10__Homo_sapiens__NP_055444

<400>  731

Met Asp Gln Arg Glu Pro Leu Pro Pro Ala Pro Ala Glu Asn Glu Met 
1               5                   10                  15      


Lys Tyr Asp Thr Asn Asn Asn Glu Glu Glu Glu Gly Glu Gln Phe Asp 
            20                  25                  30          


Phe Asp Ser Gly Asp Glu Ile Pro Glu Ala Asp Arg Gln Ala Pro Ser 
        35                  40                  45              


Ala Pro Glu Thr Gly Gly Ala Gly Ala Ser Glu Ala Pro Ala Pro Thr 
    50                  55                  60                  


Gly Gly Glu Asp Gly Ala Gly Ala Glu Thr Thr Pro Val Ala Glu Pro 
65                  70                  75                  80  


Thr Lys Leu Val Leu Pro Met Lys Val Asn Pro Tyr Ser Val Ile Asp 
                85                  90                  95      


Ile Thr Pro Phe Gln Glu Asp Gln Pro Pro Thr Pro Val Pro Ser Ala 
            100                 105                 110         


Glu Glu Glu Asn Val Gly Leu His Val Pro Cys Gly Tyr Leu Val Pro 
        115                 120                 125             


Val Pro Cys Gly Tyr Ala Val Pro Ser Asn Leu Pro Leu Leu Leu Pro 
    130                 135                 140                 


Ala Tyr Ser Ser Pro Val Ile Ile Cys Ala Thr Ser Leu Asp Glu Glu 
145                 150                 155                 160 


Glu Thr Pro Glu Val Thr Glu Asp Arg Gln Pro Asn Ser Leu Ser Ser 
                165                 170                 175     


Glu Glu Pro Pro Thr Ser Glu Asp Gln Val Gly Arg Glu Asp Ser Ala 
            180                 185                 190         


Leu Ala Arg Trp Ala Ala Asp Pro Ala Asn Thr Ala Trp Met Glu Asn 
        195                 200                 205             


Pro Glu Glu Ala Ile Tyr Asp Asp Val Pro Arg Glu Asn Ser Asp Ser 
    210                 215                 220                 


Glu Pro Asp Glu Met Ile Tyr Asp Asp Val Glu Asn Gly Asp Glu Gly 
225                 230                 235                 240 


Gly Asn Ser Ser Leu Glu Tyr Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                245                 250                 255     


Tyr Glu Glu Gln Ser Asp Ser Glu Cys Lys Asn Gly Ile Pro Arg Ser 
            260                 265                 270         


Phe Leu Arg Ser Asn His Lys Lys Gln Leu Ser His Asp Leu Thr Arg 
        275                 280                 285             


Leu Lys Glu His Tyr Glu Lys Lys Met Arg Asp Leu Met Ala Ser Thr 
    290                 295                 300                 


Val Gly Val Val Glu Ile Gln Gln Leu Arg Gln Lys His Glu Leu Lys 
305                 310                 315                 320 


Met Gln Lys Leu Val Lys Ala Ala Lys Asp Gly Thr Lys Asp Gly Leu 
                325                 330                 335     


Glu Arg Thr Arg Ala Ala Val Lys Arg Gly Arg Ser Phe Ile Arg Thr 
            340                 345                 350         


Lys Ser Leu Ile Ala Gln Asp His Arg Ser Ser Leu Glu Glu Glu Gln 
        355                 360                 365             


Asn Leu Phe Ile Asp Val Asp Cys Lys His Pro Glu Ala Ile Leu Thr 
    370                 375                 380                 


Pro Met Pro Glu Gly Leu Ser Gln Gln Gln Val Val Arg Arg Tyr Ile 
385                 390                 395                 400 


Leu Gly Ser Val Val Asp Ser Glu Lys Asn Tyr Val Asp Ala Leu Lys 
                405                 410                 415     


Arg Ile Leu Glu Gln Tyr Glu Lys Pro Leu Ser Glu Met Glu Pro Lys 
            420                 425                 430         


Val Leu Ser Glu Arg Lys Leu Lys Thr Val Phe Tyr Arg Val Lys Glu 
        435                 440                 445             


Ile Leu Gln Cys His Ser Leu Phe Gln Ile Ala Leu Ala Ser Arg Val 
    450                 455                 460                 


Ser Glu Trp Asp Ser Val Glu Met Ile Gly Asp Val Phe Val Ala Ser 
465                 470                 475                 480 


Phe Ser Lys Ser Met Val Leu Asp Ala Tyr Ser Glu Tyr Val Asn Asn 
                485                 490                 495     


Phe Ser Thr Ala Val Ala Val Leu Lys Lys Thr Cys Ala Thr Lys Pro 
            500                 505                 510         


Ala Phe Leu Glu Phe Leu Lys Gln Glu Gln Glu Ala Ser Pro Asp Arg 
        515                 520                 525             


Thr Thr Leu Tyr Ser Leu Met Met Lys Pro Ile Gln Arg Phe Pro Gln 
    530                 535                 540                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Ser Lys Gly His 
545                 550                 555                 560 


Pro Asp Arg Leu Pro Leu Gln Met Ala Leu Thr Glu Leu Glu Thr Leu 
                565                 570                 575     


Ala Glu Lys Leu Asn Glu Arg Lys Arg Asp Ala Asp Gln Arg Cys Glu 
            580                 585                 590         


Val Lys Gln Ile Ala Lys Ala Ile Asn Glu Arg Tyr Leu Asn Lys Leu 
        595                 600                 605             


Leu Ser Ser Gly Ser Arg Tyr Leu Ile Arg Ser Asp Asp Met Ile Glu 
    610                 615                 620                 


Thr Val Tyr Asn Asp Arg Gly Glu Ile Val Lys Thr Lys Glu Arg Arg 
625                 630                 635                 640 


Val Phe Met Leu Asn Asp Val Leu Met Cys Ala Thr Val Ser Ser Arg 
                645                 650                 655     


Pro Ser His Asp Ser Arg Val Met Ser Ser Gln Arg Tyr Leu Leu Lys 
            660                 665                 670         


Trp Ser Val Pro Leu Gly His Val Asp Ala Ile Glu Tyr Gly Ser Ser 
        675                 680                 685             


Ala Gly Thr Gly Glu His Ser Arg His Leu Ala Val His Pro Pro Glu 
    690                 695                 700                 


Ser Leu Ala Val Val Ala Asn Ala Lys Pro Asn Lys Val Tyr Met Gly 
705                 710                 715                 720 


Pro Gly Gln Leu Tyr Gln Asp Leu Gln Asn Leu Leu His Asp Leu Asn 
                725                 730                 735     


Val Ile Gly Gln Ile Thr Gln Leu Ile Gly Asn Leu Lys Gly Asn Tyr 
            740                 745                 750         


Gln Asn Leu Asn Gln Ser Val Ala His Asp Trp Thr Ser Gly Leu Gln 
        755                 760                 765             


Arg Leu Ile Leu Lys Lys Glu Asp Glu Ile Arg Ala Ala Asp Cys Cys 
    770                 775                 780                 


Arg Ile Gln Leu Gln Leu Pro Gly Lys Gln Asp Lys Ser Gly Arg Pro 
785                 790                 795                 800 


Thr Phe Phe Thr Ala Val Phe Asn Thr Phe Thr Pro Ala Ile Lys Glu 
                805                 810                 815     


Ser Trp Val Asn Ser Leu Gln Met Ala Lys Leu Ala Leu Glu Glu Glu 
            820                 825                 830         


Asn His Met Gly Trp Phe Cys Val Glu Asp Asp Gly Asn His Ile Lys 
        835                 840                 845             


Lys Glu Lys His Pro Leu Leu Val Gly His Met Pro Val Met Val Ala 
    850                 855                 860                 


Lys Gln Gln Glu Phe Lys Ile Glu Cys Ala Ala Tyr Asn Pro Glu Pro 
865                 870                 875                 880 


Tyr Leu Asn Asn Glu Ser Gln Pro Asp Ser Phe Ser Thr Ala His Gly 
                885                 890                 895     


Phe Leu Trp Ile Gly Ser Cys Thr His Gln Met Gly Gln Ile Ala Ile 
            900                 905                 910         


Val Ser Phe Gln Asn Ser Thr Pro Lys Val Ile Glu Cys Phe Asn Val 
        915                 920                 925             


Glu Ser Arg Ile Leu Cys Met Leu Tyr Val Pro Val Glu Glu Lys Arg 
    930                 935                 940                 


Arg Glu Pro Gly Ala Pro Pro Asp Pro Glu Thr Pro Ala Val Arg Ala 
945                 950                 955                 960 


Ser Asp Val Pro Thr Ile Cys Val Gly Thr Glu Glu Gly Ser Ile Ser 
                965                 970                 975     


Ile Tyr Lys Ser Ser Gln Gly Ser Lys Lys Val Arg Leu Gln His Phe 
            980                 985                 990         


Phe Thr Pro Glu Lys Ser Thr Val  Met Ser Leu Ala Cys  Thr Ser Gln 
        995                 1000                 1005             


Ser Leu  Tyr Ala Gly Leu Val  Asn Gly Ala Val Ala  Ser Tyr Ala 
    1010                 1015                 1020             


Arg Ala  Pro Asp Gly Ser Trp  Asp Ser Glu Pro Gln  Lys Val Ile 
    1025                 1030                 1035             


Lys Leu  Gly Val Leu Pro Val  Arg Ser Leu Leu Met  Met Glu Asp 
    1040                 1045                 1050             


Thr Leu  Trp Ala Ala Ser Gly  Gly Gln Val Phe Ile  Ile Ser Val 
    1055                 1060                 1065             


Glu Thr  His Ala Val Glu Gly  Gln Leu Glu Ala His  Gln Glu Glu 
    1070                 1075                 1080             


Gly Met  Val Ile Ser His Met  Ala Val Ser Gly Val  Gly Ile Trp 
    1085                 1090                 1095             


Ile Ala  Phe Thr Ser Gly Ser  Thr Leu Arg Leu Phe  His Thr Glu 
    1100                 1105                 1110             


Thr Leu  Lys His Leu Gln Asp  Ile Asn Ile Ala Thr  Pro Val His 
    1115                 1120                 1125             


Asn Met  Leu Pro Gly His Gln  Arg Leu Ser Val Thr  Ser Leu Leu 
    1130                 1135                 1140             


Val Cys  His Gly Leu Leu Met  Val Gly Thr Ser Leu  Gly Val Leu 
    1145                 1150                 1155             


Val Ala  Leu Pro Val Pro Arg  Leu Gln Gly Ile Pro  Lys Val Thr 
    1160                 1165                 1170             


Gly Arg  Gly Met Val Ser Tyr  His Ala His Asn Ser  Pro Val Lys 
    1175                 1180                 1185             


Phe Ile  Val Leu Ala Thr Ala  Leu His Glu Lys Asp  Lys Asp Lys 
    1190                 1195                 1200             


Ser Arg  Asp Ser Leu Ala Pro  Gly Pro Glu Pro Gln  Asp Glu Asp 
    1205                 1210                 1215             


Gln Lys  Asp Ala Leu Pro Ser  Gly Gly Ala Gly Ser  Ser Leu Ser 
    1220                 1225                 1230             


Gln Gly  Asp Pro Asp Ala Ala  Ile Trp Leu Gly Asp  Ser Leu Gly 
    1235                 1240                 1245             


Ser Met  Thr Gln Lys Ser Asp  Leu Ser Ser Ser Ser  Gly Ser Leu 
    1250                 1255                 1260             


Ser Leu  Ser His Gly Ser Ser  Ser Leu Glu His Arg  Ser Glu Asp 
    1265                 1270                 1275             


Ser Thr  Ile Tyr Asp Leu Leu  Lys Asp Pro Val Ser  Leu Arg Ser 
    1280                 1285                 1290             


Lys Ala  Arg Arg Ala Lys Lys  Ala Lys Ala Ser Ser  Ala Leu Val 
    1295                 1300                 1305             


Val Cys  Gly Gly Gln Gly His  Arg Arg Val His Arg  Lys Ala Arg 
    1310                 1315                 1320             


Gln Pro  His Gln Glu Glu Leu  Ala Pro Thr Val Met  Val Trp Gln 
    1325                 1330                 1335             


Ile Pro  Leu Leu Asn Ile 
    1340                 


<210>  732
<211>  1241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF10L__Homo_sapiens__XP_011539993

<400>  732

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Ala Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly 
145                 150                 155                 160 


Ala Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu 
                165                 170                 175     


Ser Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val 
            180                 185                 190         


Glu Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Met Thr Gln Leu 
        195                 200                 205             


Met Lys Ala Ala Lys Ser Gly Thr Lys Asp Gly Leu Glu Lys Thr Arg 
    210                 215                 220                 


Met Ala Val Met Arg Lys Val Ser Phe Leu His Arg Lys Asp Val Leu 
225                 230                 235                 240 


Gly Asp Ser Glu Glu Glu Asp Met Gly Leu Leu Glu Val Ser Val Ser 
                245                 250                 255     


Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly Pro Met Pro Glu Gly Leu 
            260                 265                 270         


Ser Pro Gln Gln Val Val Arg Arg His Ile Leu Gly Ser Ile Val Gln 
        275                 280                 285             


Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys Arg Ile Leu Gln Asp Tyr 
    290                 295                 300                 


Arg Asn Pro Leu Met Glu Met Glu Pro Lys Ala Leu Ser Ala Arg Lys 
305                 310                 315                 320 


Cys Gln Val Val Phe Phe Arg Val Lys Glu Ile Leu His Cys His Ser 
                325                 330                 335     


Met Phe Gln Ile Ala Leu Ser Ser Arg Val Ala Glu Trp Asp Ser Thr 
            340                 345                 350         


Glu Lys Ile Gly Asp Leu Phe Val Ala Ser Phe Ser Lys Ser Met Val 
        355                 360                 365             


Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn Phe Thr Ser Ala Met Ser 
    370                 375                 380                 


Ile Ile Lys Lys Ala Cys Leu Thr Lys Pro Ala Phe Leu Glu Phe Leu 
385                 390                 395                 400 


Lys Arg Arg Gln Val Cys Ser Pro Asp Arg Val Thr Leu Tyr Gly Leu 
                405                 410                 415     


Met Val Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln 
            420                 425                 430         


Asp Met Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu Ser Leu 
        435                 440                 445             


Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu 
    450                 455                 460                 


Gln Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Thr Lys 
465                 470                 475                 480 


Ser Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser Gly Gln 
                485                 490                 495     


Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr Gly Asp 
            500                 505                 510         


Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn 
        515                 520                 525             


Asp Met Leu Val Cys Ala Asn Ile Asn Phe Lys Pro Ala Asn His Arg 
    530                 535                 540                 


Gly Gln Leu Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr Val 
545                 550                 555                 560 


Val Lys Trp Asn Thr Ala Leu Pro Gln Val Gln Val Val Glu Val Gly 
                565                 570                 575     


Gln Asp Gly Gly Thr Tyr Asp Lys Asp Asn Val Leu Ile Gln His Ser 
            580                 585                 590         


Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr 
        595                 600                 605             


Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp 
    610                 615                 620                 


Leu Ala Val Val Glu Gln Ile Thr Leu Leu Ile Ser Thr Leu His Gly 
625                 630                 635                 640 


Thr Tyr Gln Asn Leu Asn Met Thr Val Ala Gln Asp Trp Cys Leu Ala 
                645                 650                 655     


Leu Gln Arg Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala Asn 
            660                 665                 670         


Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly 
        675                 680                 685             


Arg Pro Ile Ser Phe Met Val Val Phe Ile Thr Pro Asn Pro Leu Ser 
    690                 695                 700                 


Lys Ile Ser Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu Arg 
705                 710                 715                 720 


Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser 
                725                 730                 735     


Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe 
            740                 745                 750         


Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser Pro 
        755                 760                 765             


Val Asn Cys Pro Leu Leu Gly Phe Ser Ala Val Ser Thr Ser Leu Pro 
    770                 775                 780                 


Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln 
785                 790                 795                 800 


Val Glu Ile Phe Ser Leu Asn Arg Pro Ser Pro Arg Thr Val Lys Ser 
                805                 810                 815     


Phe Pro Leu Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu Leu 
            820                 825                 830         


Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser Pro Thr Val Ala Asp Pro 
        835                 840                 845             


Ser Ala Thr Val His Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly Ser 
    850                 855                 860                 


Ile Leu Leu Tyr Ser Ser Val Asp Thr Gly Thr Gln Cys Leu Val Ser 
865                 870                 875                 880 


Cys Arg Ser Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser Pro 
                885                 890                 895     


Phe His Leu Leu Ala Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr Pro 
            900                 905                 910         


Arg Thr Ser Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val Cys 
        915                 920                 925             


Leu Thr Val Gly Pro Gly Pro Val Arg Thr Leu Leu Ser Leu Glu Asp 
    930                 935                 940                 


Ala Val Trp Ala Ser Cys Gly Pro Arg Val Thr Val Leu Glu Ala Thr 
945                 950                 955                 960 


Thr Leu Gln Pro Gln Gln Ser Phe Glu Ala His Gln Asp Glu Ala Val 
                965                 970                 975     


Ser Val Thr His Met Val Lys Ala Gly Ser Gly Val Trp Met Ala Phe 
            980                 985                 990         


Ser Ser Gly Thr Ser Ile Arg Leu  Phe His Thr Glu Thr  Leu Glu His 
        995                 1000                 1005             


Leu Gln  Glu Ile Asn Ile Ala  Thr Arg Thr Thr Phe  Leu Leu Pro 
    1010                 1015                 1020             


Gly Gln  Lys His Leu Cys Val  Thr Ser Leu Leu Ile  Cys Gln Gly 
    1025                 1030                 1035             


Leu Leu  Trp Val Gly Thr Asp  Gln Gly Val Ile Val  Leu Leu Pro 
    1040                 1045                 1050             


Val Pro  Arg Leu Glu Gly Ile  Pro Lys Ile Thr Gly  Lys Gly Met 
    1055                 1060                 1065             


Val Ser  Leu Asn Gly His Cys  Gly Pro Val Ala Phe  Leu Ala Val 
    1070                 1075                 1080             


Ala Thr  Ser Ile Leu Ala Pro  Asp Ile Leu Arg Ser  Asp Gln Glu 
    1085                 1090                 1095             


Glu Ala  Glu Gly Pro Arg Ala  Glu Glu Asp Lys Pro  Asp Gly Gln 
    1100                 1105                 1110             


Ala His  Glu Pro Met Pro Asp  Ser His Val Gly Arg  Glu Leu Thr 
    1115                 1120                 1125             


Arg Lys  Lys Gly Ile Leu Leu  Gln Tyr Arg Leu Arg  Ser Thr Ala 
    1130                 1135                 1140             


His Leu  Pro Gly Pro Leu Leu  Ser Met Arg Glu Pro  Ala Pro Ala 
    1145                 1150                 1155             


Asp Gly  Ala Ala Leu Glu His  Ser Glu Glu Asp Gly  Ser Ile Tyr 
    1160                 1165                 1170             


Glu Met  Ala Asp Asp Pro Asp  Ile Trp Val Arg Ser  Arg Pro Cys 
    1175                 1180                 1185             


Ala Arg  Asp Ala His Arg Lys  Glu Ile Cys Ser Val  Ala Ile Ile 
    1190                 1195                 1200             


Ser Gly  Gly Gln Gly Tyr Arg  Asn Phe Gly Ser Ala  Leu Gly Ser 
    1205                 1210                 1215             


Ser Gly  Arg Gln Ala Pro Cys  Gly Glu Thr Asp Ser  Thr Leu Leu 
    1220                 1225                 1230             


Ile Trp  Gln Val Pro Leu Met  Leu 
    1235                 1240     


<210>  733
<211>  1522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF11__Homo_sapiens__NP_055599

<400>  733

Met Ser Val Arg Leu Pro Gln Ser Ile Asp Arg Leu Ser Ser Leu Ser 
1               5                   10                  15      


Ser Leu Gly Asp Ser Ala Pro Glu Arg Lys Ser Pro Ser His His Arg 
            20                  25                  30          


Gln Pro Ser Asp Ala Ser Glu Thr Thr Gly Leu Val Gln Arg Cys Val 
        35                  40                  45              


Ile Ile Gln Lys Asp Gln His Gly Phe Gly Phe Thr Val Ser Gly Asp 
    50                  55                  60                  


Arg Ile Val Leu Val Gln Ser Val Arg Pro Gly Gly Ala Ala Met Lys 
65                  70                  75                  80  


Ala Gly Val Lys Glu Gly Asp Arg Ile Ile Lys Val Asn Gly Thr Met 
                85                  90                  95      


Val Thr Asn Ser Ser His Leu Glu Val Val Lys Leu Ile Lys Ser Gly 
            100                 105                 110         


Ala Tyr Val Ala Leu Thr Leu Leu Gly Ser Ser Pro Ser Ser Met Gly 
        115                 120                 125             


Ile Ser Gly Leu Gln Gln Asp Pro Ser Pro Ala Gly Ala Pro Arg Ile 
    130                 135                 140                 


Thr Ser Val Ile Pro Ser Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro 
145                 150                 155                 160 


Gln Arg Ile Thr Gly Pro Lys Pro Leu Gln Asp Pro Glu Val Gln Lys 
                165                 170                 175     


His Ala Thr Gln Ile Leu Arg Asn Met Leu Arg Gln Glu Glu Lys Glu 
            180                 185                 190         


Leu Gln Asp Ile Leu Pro Leu Tyr Gly Asp Thr Ser Gln Arg Pro Ser 
        195                 200                 205             


Glu Gly Arg Leu Ser Leu Asp Ser Gln Glu Gly Asp Ser Gly Leu Asp 
    210                 215                 220                 


Ser Gly Thr Glu Arg Phe Pro Ser Leu Ser Glu Ser Leu Met Asn Arg 
225                 230                 235                 240 


Asn Ser Val Leu Ser Asp Pro Gly Leu Asp Ser Pro Arg Thr Ser Pro 
                245                 250                 255     


Val Ile Met Ala Arg Val Ala Gln His His Arg Arg Gln Gly Ser Asp 
            260                 265                 270         


Ala Ala Val Pro Ser Thr Gly Asp Gln Gly Val Asp Gln Ser Pro Lys 
        275                 280                 285             


Pro Leu Ile Ile Gly Pro Glu Glu Asp Tyr Asp Pro Gly Tyr Phe Asn 
    290                 295                 300                 


Asn Glu Ser Asp Ile Ile Phe Gln Asp Leu Glu Lys Leu Lys Ser Arg 
305                 310                 315                 320 


Pro Ala His Leu Gly Val Phe Leu Arg Tyr Ile Phe Ser Gln Ala Asp 
                325                 330                 335     


Pro Ser Pro Leu Leu Phe Tyr Leu Cys Ala Glu Val Tyr Gln Gln Ala 
            340                 345                 350         


Ser Pro Lys Asp Ser Arg Ser Leu Gly Lys Asp Ile Trp Asn Ile Phe 
        355                 360                 365             


Leu Glu Lys Asn Ala Pro Leu Arg Val Lys Ile Pro Glu Met Leu Gln 
    370                 375                 380                 


Ala Glu Ile Asp Ser Arg Leu Arg Asn Ser Glu Asp Ala Arg Gly Val 
385                 390                 395                 400 


Leu Cys Glu Ala Gln Glu Ala Ala Met Pro Glu Ile Gln Glu Gln Ile 
                405                 410                 415     


His Asp Tyr Arg Thr Lys Arg Thr Leu Gly Leu Gly Ser Leu Tyr Gly 
            420                 425                 430         


Glu Asn Asp Leu Leu Asp Leu Asp Gly Asp Pro Leu Arg Glu Arg Gln 
        435                 440                 445             


Val Ala Glu Lys Gln Leu Ala Ala Leu Gly Asp Ile Leu Ser Lys Tyr 
    450                 455                 460                 


Glu Glu Asp Arg Ser Ala Pro Met Asp Phe Ala Leu Asn Thr Tyr Met 
465                 470                 475                 480 


Ser His Ala Gly Ile Arg Leu Arg Glu Ala Arg Pro Ser Asn Thr Ala 
                485                 490                 495     


Glu Lys Ala Gln Ser Ala Pro Asp Lys Asp Lys Trp Leu Pro Phe Phe 
            500                 505                 510         


Pro Lys Thr Lys Lys Ser Ser Asn Ser Lys Lys Glu Lys Asp Ala Leu 
        515                 520                 525             


Glu Asp Lys Lys Arg Asn Pro Ile Leu Lys Tyr Ile Gly Lys Pro Lys 
    530                 535                 540                 


Ser Ser Ser Gln Ser Thr Phe His Ile Pro Leu Ser Pro Val Glu Val 
545                 550                 555                 560 


Lys Pro Gly Asn Val Arg Asn Ile Ile Gln His Phe Glu Asn Asn Gln 
                565                 570                 575     


Gln Tyr Asp Ala Pro Glu Pro Gly Thr Gln Arg Leu Ser Thr Gly Ser 
            580                 585                 590         


Phe Pro Glu Asp Leu Leu Glu Ser Asp Ser Ser Arg Ser Glu Ile Arg 
        595                 600                 605             


Leu Gly Arg Ser Glu Ser Leu Lys Gly Arg Glu Glu Met Lys Arg Ser 
    610                 615                 620                 


Arg Lys Ala Glu Asn Val Pro Arg Ser Arg Ser Asp Val Asp Met Asp 
625                 630                 635                 640 


Ala Ala Ala Glu Ala Thr Arg Leu His Gln Ser Ala Ser Ser Ser Thr 
                645                 650                 655     


Ser Ser Leu Ser Thr Arg Ser Leu Glu Asn Pro Thr Pro Pro Phe Thr 
            660                 665                 670         


Pro Lys Met Gly Arg Arg Ser Ile Glu Ser Pro Ser Leu Gly Phe Cys 
        675                 680                 685             


Thr Asp Thr Leu Leu Pro His Leu Leu Glu Asp Asp Leu Gly Gln Leu 
    690                 695                 700                 


Ser Asp Leu Glu Pro Glu Pro Asp Ala Gln Asn Trp Gln His Thr Val 
705                 710                 715                 720 


Gly Lys Asp Val Val Ala Gly Leu Thr Gln Arg Glu Ile Asp Arg Gln 
                725                 730                 735     


Glu Val Ile Asn Glu Leu Phe Val Thr Glu Ala Ser His Leu Arg Thr 
            740                 745                 750         


Leu Arg Val Leu Asp Leu Ile Phe Tyr Gln Arg Met Lys Lys Glu Asn 
        755                 760                 765             


Leu Met Pro Arg Glu Glu Leu Ala Arg Leu Phe Pro Asn Leu Pro Glu 
    770                 775                 780                 


Leu Ile Glu Ile His Asn Ser Trp Cys Glu Ala Met Lys Lys Leu Arg 
785                 790                 795                 800 


Glu Glu Gly Pro Ile Ile Lys Glu Ile Ser Asp Leu Met Leu Ala Arg 
                805                 810                 815     


Phe Asp Gly Pro Ala Arg Glu Glu Leu Gln Gln Val Ala Ala Gln Phe 
            820                 825                 830         


Cys Ser Tyr Gln Ser Ile Ala Leu Glu Leu Ile Lys Thr Lys Gln Arg 
        835                 840                 845             


Lys Glu Ser Arg Phe Gln Leu Phe Met Gln Glu Ala Glu Ser His Pro 
    850                 855                 860                 


Gln Cys Arg Arg Leu Gln Leu Arg Asp Leu Ile Ile Ser Glu Met Gln 
865                 870                 875                 880 


Arg Leu Thr Lys Tyr Pro Leu Leu Leu Glu Ser Ile Ile Lys His Thr 
                885                 890                 895     


Glu Gly Gly Thr Ser Glu His Glu Lys Leu Cys Arg Ala Arg Asp Gln 
            900                 905                 910         


Cys Arg Glu Ile Leu Lys Tyr Val Asn Glu Ala Val Lys Gln Thr Glu 
        915                 920                 925             


Asn Arg His Arg Leu Glu Gly Tyr Gln Lys Arg Leu Asp Ala Thr Ala 
    930                 935                 940                 


Leu Glu Arg Ala Ser Asn Pro Leu Ala Ala Glu Phe Lys Ser Leu Asp 
945                 950                 955                 960 


Leu Thr Thr Arg Lys Met Ile His Glu Gly Pro Leu Thr Trp Arg Ile 
                965                 970                 975     


Ser Lys Asp Lys Thr Leu Asp Leu His Val Leu Leu Leu Glu Asp Leu 
            980                 985                 990         


Leu Val Leu Leu Gln Lys Gln Asp  Glu Lys Leu Leu Leu  Lys Cys His 
        995                 1000                 1005             


Ser Lys  Thr Ala Val Gly Ser  Ser Asp Ser Lys Gln  Thr Phe Ser 
    1010                 1015                 1020             


Pro Val  Leu Lys Leu Asn Ala  Val Leu Ile Arg Ser  Val Ala Thr 
    1025                 1030                 1035             


Asp Lys  Arg Ala Phe Phe Ile  Ile Cys Thr Ser Lys  Leu Gly Pro 
    1040                 1045                 1050             


Pro Gln  Ile Tyr Glu Leu Val  Ala Leu Thr Ser Ser  Asp Lys Asn 
    1055                 1060                 1065             


Thr Trp  Met Glu Leu Leu Glu  Glu Ala Val Arg Asn  Ala Thr Arg 
    1070                 1075                 1080             


His Pro  Gly Ala Ala Pro Met  Pro Val His Pro Pro  Pro Pro Gly 
    1085                 1090                 1095             


Pro Arg  Glu Pro Ala Gln Gln  Gly Pro Thr Pro Ser  Arg Val Glu 
    1100                 1105                 1110             


Leu Asp  Asp Ser Asp Val Phe  His Gly Glu Pro Glu  Pro Glu Glu 
    1115                 1120                 1125             


Leu Pro  Gly Gly Thr Gly Ser  Gln Gln Arg Val Gln  Gly Lys His 
    1130                 1135                 1140             


Gln Val  Leu Leu Glu Asp Pro  Glu Gln Glu Gly Ser  Ala Glu Glu 
    1145                 1150                 1155             


Glu Glu  Leu Gly Val Leu Pro  Cys Pro Ser Thr Ser  Leu Asp Gly 
    1160                 1165                 1170             


Glu Asn  Arg Gly Ile Arg Thr  Arg Asn Pro Ile His  Leu Ala Phe 
    1175                 1180                 1185             


Pro Gly  Pro Leu Phe Met Glu  Gly Leu Ala Asp Ser  Ala Leu Glu 
    1190                 1195                 1200             


Asp Val  Glu Asn Leu Arg His  Leu Ile Leu Trp Ser  Leu Leu Pro 
    1205                 1210                 1215             


Gly His  Thr Met Glu Thr Gln  Ala Ala Gln Glu Pro  Glu Asp Asp 
    1220                 1225                 1230             


Leu Thr  Pro Thr Pro Ser Val  Ile Ser Val Thr Ser  His Pro Trp 
    1235                 1240                 1245             


Asp Pro  Gly Ser Pro Gly Gln  Ala Pro Pro Gly Gly  Glu Gly Asp 
    1250                 1255                 1260             


Asn Thr  Gln Leu Ala Gly Leu  Glu Gly Glu Arg Pro  Glu Gln Glu 
    1265                 1270                 1275             


Asp Met  Gly Leu Cys Ser Leu  Glu His Leu Pro Pro  Arg Thr Arg 
    1280                 1285                 1290             


Asn Ser  Gly Ile Trp Glu Ser  Pro Glu Leu Asp Arg  Asn Leu Ala 
    1295                 1300                 1305             


Glu Asp  Ala Ser Ser Thr Glu  Ala Ala Gly Gly Tyr  Lys Val Val 
    1310                 1315                 1320             


Arg Lys  Ala Glu Val Ala Gly  Ser Lys Val Val Pro  Ala Leu Pro 
    1325                 1330                 1335             


Glu Ser  Gly Gln Ser Glu Pro  Gly Pro Pro Glu Val  Glu Gly Gly 
    1340                 1345                 1350             


Thr Lys  Ala Thr Gly Asn Cys  Phe Tyr Val Ser Met  Pro Ser Gly 
    1355                 1360                 1365             


Pro Pro  Asp Ser Ser Thr Asp  His Ser Glu Ala Pro  Met Ser Pro 
    1370                 1375                 1380             


Pro Gln  Pro Asp Ser Leu Pro  Ala Gly Gln Thr Glu  Pro Gln Pro 
    1385                 1390                 1395             


Gln Leu  Gln Gly Gly Asn Asp  Asp Pro Arg Arg Pro  Ser Arg Ser 
    1400                 1405                 1410             


Pro Pro  Ser Leu Ala Leu Arg  Asp Val Gly Met Ile  Phe His Thr 
    1415                 1420                 1425             


Ile Glu  Gln Leu Thr Leu Lys  Leu Asn Arg Leu Lys  Asp Met Glu 
    1430                 1435                 1440             


Leu Ala  His Arg Glu Leu Leu  Lys Ser Leu Gly Gly  Glu Ser Ser 
    1445                 1450                 1455             


Gly Gly  Thr Thr Pro Val Gly  Ser Phe His Thr Glu  Ala Ala Arg 
    1460                 1465                 1470             


Trp Thr  Asp Gly Ser Leu Ser  Pro Pro Ala Lys Glu  Pro Leu Ala 
    1475                 1480                 1485             


Ser Asp  Ser Arg Asn Ser His  Glu Leu Gly Pro Cys  Pro Glu Asp 
    1490                 1495                 1500             


Gly Ser  Asp Ala Pro Leu Glu  Asp Ser Thr Ala Asp  Ala Ala Ala 
    1505                 1510                 1515             


Ser Pro  Gly Pro 
    1520         


<210>  734
<211>  1525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF12__Homo_sapiens__NP_001185594

<400>  734

Met Ser Gly Thr Gln Ser Thr Ile Thr Asp Arg Phe Pro Leu Lys Lys 
1               5                   10                  15      


Pro Ile Arg His Gly Ser Ile Leu Asn Arg Glu Ser Pro Thr Asp Lys 
            20                  25                  30          


Lys Gln Lys Val Glu Arg Ile Ala Ser His Asp Phe Asp Pro Thr Gly 
        35                  40                  45              


Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Asp Asn Gly Phe Gly 
    50                  55                  60                  


Leu Thr Val Ser Gly Asp Asn Pro Val Phe Val Gln Ser Val Lys Glu 
65                  70                  75                  80  


Asp Gly Ala Ala Met Arg Ala Gly Val Gln Thr Gly Asp Arg Ile Ile 
                85                  90                  95      


Lys Val Asn Gly Thr Leu Val Thr His Ser Asn His Leu Glu Val Val 
            100                 105                 110         


Lys Leu Ile Lys Ser Gly Ser Tyr Val Ala Leu Thr Val Gln Gly Arg 
        115                 120                 125             


Pro Pro Gly Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu Val Glu Pro 
    130                 135                 140                 


Ser Val Ile Gly His Met Ser Pro Ile Met Thr Ser Pro His Ser Pro 
145                 150                 155                 160 


Gly Ala Ser Gly Asn Met Glu Arg Ile Thr Ser Pro Val Leu Met Gly 
                165                 170                 175     


Glu Glu Asn Asn Val Val His Asn Gln Lys Val Glu Ile Leu Arg Lys 
            180                 185                 190         


Met Leu Gln Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln Glu Asp Tyr 
        195                 200                 205             


Asn Arg Thr Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln Glu Ala Lys 
    210                 215                 220                 


Lys His Ile Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala Thr Gly Ser 
225                 230                 235                 240 


Ala Gln Asp Gly Ala Val Val Thr Pro Ser Arg Pro Leu Gly Asp Thr 
                245                 250                 255     


Leu Thr Val Ser Glu Ala Glu Thr Asp Pro Gly Asp Val Leu Gly Arg 
            260                 265                 270         


Thr Asp Cys Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser Asp Asn Ala 
        275                 280                 285             


Asp Ser Pro Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu Glu Glu Asn 
    290                 295                 300                 


Pro Glu Lys Ser Glu Thr Ile Gln Asp Thr Asp Thr Gln Ser Leu Val 
305                 310                 315                 320 


Gly Ser Pro Ser Thr Arg Ile Ala Pro His Ile Ile Gly Ala Glu Asp 
                325                 330                 335     


Asp Asp Phe Gly Thr Glu His Glu Gln Ile Asn Gly Gln Cys Ser Cys 
            340                 345                 350         


Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His Leu Ala Val 
        355                 360                 365             


Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Thr Leu Leu Cys 
    370                 375                 380                 


Tyr Leu Tyr Ser Asp Leu Tyr Lys His Thr Asn Ser Lys Glu Thr Arg 
385                 390                 395                 400 


Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg Ser Ala His 
                405                 410                 415     


Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu Glu Lys Arg 
            420                 425                 430         


Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr Ile Gln Thr 
        435                 440                 445             


Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu Glu Asp Phe 
    450                 455                 460                 


Arg Gln Lys Arg Ser Met Gly Leu Thr Leu Ala Glu Ser Glu Leu Thr 
465                 470                 475                 480 


Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Thr Leu Glu Lys Glu 
                485                 490                 495     


Arg Thr Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu Val Leu Met 
            500                 505                 510         


Thr Ala Gln Ala Val Glu Glu Asp Lys Ser Ser Thr Met Gln Tyr Val 
        515                 520                 525             


Ile Leu Met Tyr Met Lys His Leu Gly Val Lys Val Lys Glu Pro Arg 
    530                 535                 540                 


Asn Leu Glu His Lys Arg Gly Arg Ile Gly Phe Leu Pro Lys Ile Lys 
545                 550                 555                 560 


Gln Ser Met Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly Lys Arg Arg 
                565                 570                 575     


Gly Phe Pro Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser Arg His Asp 
            580                 585                 590         


Asn Ser Ala Ile Gly Arg Ala Met Glu Leu Gln Lys Ala Arg His Pro 
        595                 600                 605             


Lys His Leu Ser Thr Pro Ser Ser Val Ser Pro Glu Pro Gln Asp Ser 
    610                 615                 620                 


Ala Lys Leu Arg Gln Ser Gly Leu Ala Asn Glu Gly Thr Asp Ala Gly 
625                 630                 635                 640 


Tyr Leu Pro Ala Asn Ser Met Ser Ser Val Ala Ser Gly Ala Ser Phe 
                645                 650                 655     


Ser Gln Glu Gly Gly Lys Glu Asn Asp Thr Gly Ser Lys Gln Val Gly 
            660                 665                 670         


Glu Thr Ser Ala Pro Gly Asp Thr Leu Asp Gly Thr Pro Arg Thr Leu 
        675                 680                 685             


Asn Thr Val Phe Asp Phe Pro Pro Pro Pro Leu Asp Gln Val Gln Glu 
    690                 695                 700                 


Glu Glu Cys Glu Val Glu Arg Val Thr Glu His Gly Thr Pro Lys Pro 
705                 710                 715                 720 


Phe Arg Lys Phe Asp Ser Val Ala Phe Gly Glu Ser Gln Ser Glu Asp 
                725                 730                 735     


Glu Gln Phe Glu Asn Asp Leu Glu Thr Asp Pro Pro Asn Trp Gln Gln 
            740                 745                 750         


Leu Val Ser Arg Glu Val Leu Leu Gly Leu Lys Pro Cys Glu Ile Lys 
        755                 760                 765             


Arg Gln Glu Val Ile Asn Glu Leu Phe Tyr Thr Glu Arg Ala His Val 
    770                 775                 780                 


Arg Thr Leu Lys Val Leu Asp Gln Val Phe Tyr Gln Arg Val Ser Arg 
785                 790                 795                 800 


Glu Gly Ile Leu Ser Pro Ser Glu Leu Arg Lys Ile Phe Ser Asn Leu 
                805                 810                 815     


Glu Asp Ile Leu Gln Leu His Ile Gly Leu Asn Glu Gln Met Lys Ala 
            820                 825                 830         


Val Arg Lys Arg Asn Glu Thr Ser Val Ile Asp Gln Ile Gly Glu Asp 
        835                 840                 845             


Leu Leu Thr Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu Lys His Ala 
    850                 855                 860                 


Ala Ala Thr Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu Met Ile Lys 
865                 870                 875                 880 


Ser Arg Gln Lys Lys Asp Ser Arg Phe Gln Thr Phe Val Gln Asp Ala 
                885                 890                 895     


Glu Ser Asn Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp Ile Ile Pro 
            900                 905                 910         


Thr Gln Met Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu Asp Asn Ile 
        915                 920                 925             


Ala Lys Tyr Thr Glu Trp Pro Thr Glu Arg Glu Lys Val Lys Lys Ala 
    930                 935                 940                 


Ala Asp His Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln Ala Val Lys 
945                 950                 955                 960 


Glu Ala Glu Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg Arg Leu Asp 
                965                 970                 975     


Thr Ser Ser Leu Lys Leu Ser Glu Tyr Pro Asn Val Glu Glu Leu Arg 
            980                 985                 990         


Asn Leu Asp Leu Thr Lys Arg Lys  Met Ile His Glu Gly  Pro Leu Val 
        995                 1000                 1005             


Trp Lys  Val Asn Arg Asp Lys  Thr Ile Asp Leu Tyr  Thr Leu Leu 
    1010                 1015                 1020             


Leu Glu  Asp Ile Leu Val Leu  Leu Gln Lys Gln Asp  Asp Arg Leu 
    1025                 1030                 1035             


Val Leu  Arg Cys His Ser Lys  Ile Leu Ala Ser Thr  Ala Asp Ser 
    1040                 1045                 1050             


Lys His  Thr Phe Ser Pro Val  Ile Lys Leu Ser Thr  Val Leu Val 
    1055                 1060                 1065             


Arg Gln  Val Ala Thr Asp Asn  Lys Ala Leu Phe Val  Ile Ser Met 
    1070                 1075                 1080             


Ser Asp  Asn Gly Ala Gln Ile  Tyr Glu Leu Val Ala  Gln Thr Val 
    1085                 1090                 1095             


Ser Glu  Lys Thr Val Trp Gln  Asp Leu Ile Cys Arg  Met Ala Ala 
    1100                 1105                 1110             


Ser Val  Lys Glu Gln Ser Thr  Lys Pro Ile Pro Leu  Pro Gln Ser 
    1115                 1120                 1125             


Thr Pro  Gly Glu Gly Asp Asn  Asp Glu Glu Asp Pro  Ser Lys Leu 
    1130                 1135                 1140             


Lys Glu  Glu Gln His Gly Ile  Ser Val Thr Gly Leu  Gln Ser Pro 
    1145                 1150                 1155             


Asp Arg  Asp Leu Gly Leu Glu  Ser Thr Leu Ile Ser  Ser Lys Pro 
    1160                 1165                 1170             


Gln Ser  His Ser Leu Ser Thr  Ser Gly Lys Ser Glu  Val Arg Asp 
    1175                 1180                 1185             


Leu Phe  Val Ala Glu Arg Gln  Phe Ala Lys Glu Gln  His Thr Asp 
    1190                 1195                 1200             


Gly Thr  Leu Lys Glu Val Gly  Glu Asp Tyr Gln Ile  Ala Ile Pro 
    1205                 1210                 1215             


Asp Ser  His Leu Pro Val Ser  Glu Glu Arg Trp Ala  Leu Asp Ala 
    1220                 1225                 1230             


Leu Arg  Asn Leu Gly Leu Leu  Lys Gln Leu Leu Val  Gln Gln Leu 
    1235                 1240                 1245             


Gly Leu  Thr Glu Lys Ser Val  Gln Glu Asp Trp Gln  His Phe Pro 
    1250                 1255                 1260             


Arg Tyr  Arg Thr Ala Ser Gln  Gly Pro Gln Thr Asp  Ser Val Ile 
    1265                 1270                 1275             


Gln Asn  Ser Glu Asn Ile Lys  Ala Tyr His Ser Gly  Glu Gly His 
    1280                 1285                 1290             


Met Pro  Phe Arg Thr Gly Thr  Gly Asp Ile Ala Thr  Cys Tyr Ser 
    1295                 1300                 1305             


Pro Arg  Thr Ser Thr Glu Ser  Phe Ala Pro Arg Asp  Ser Val Gly 
    1310                 1315                 1320             


Leu Ala  Pro Gln Asp Ser Gln  Ala Ser Asn Ile Leu  Val Met Asp 
    1325                 1330                 1335             


His Met  Ile Met Thr Pro Glu  Met Pro Thr Met Glu  Pro Glu Gly 
    1340                 1345                 1350             


Gly Leu  Asp Asp Ser Gly Glu  His Phe Phe Asp Ala  Arg Glu Ala 
    1355                 1360                 1365             


His Ser  Asp Glu Asn Pro Ser  Glu Gly Asp Gly Ala  Val Asn Lys 
    1370                 1375                 1380             


Glu Glu  Lys Asp Val Asn Leu  Arg Ile Ser Gly Asn  Tyr Leu Ile 
    1385                 1390                 1395             


Leu Asp  Gly Tyr Asp Pro Val  Gln Glu Ser Ser Thr  Asp Glu Glu 
    1400                 1405                 1410             


Val Ala  Ser Ser Leu Thr Leu  Gln Pro Met Thr Gly  Ile Pro Ala 
    1415                 1420                 1425             


Val Glu  Ser Thr His Gln Gln  Gln His Ser Pro Gln  Asn Thr His 
    1430                 1435                 1440             


Ser Asp  Gly Ala Ile Ser Pro  Phe Thr Pro Glu Phe  Leu Val Gln 
    1445                 1450                 1455             


Gln Arg  Trp Gly Ala Met Glu  Tyr Ser Cys Phe Glu  Ile Gln Ser 
    1460                 1465                 1470             


Pro Ser  Ser Cys Ala Asp Ser  Gln Ser Gln Ile Met  Glu Tyr Ile 
    1475                 1480                 1485             


His Lys  Ile Glu Ala Asp Leu  Glu His Leu Lys Lys  Val Glu Glu 
    1490                 1495                 1500             


Ser Tyr  Thr Ile Leu Cys Gln  Arg Leu Ala Gly Ser  Ala Leu Thr 
    1505                 1510                 1515             


Asp Lys  His Ser Asp Lys Ser  
    1520                 1525 


<210>  735
<211>  841
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF15__Homo_sapiens__NP_776089

<400>  735

Met Ser Ala Gln Ser Leu Pro Ala Ala Thr Pro Pro Thr Gln Lys Pro 
1               5                   10                  15      


Pro Arg Ile Ile Arg Pro Arg Pro Pro Ser Arg Ser Arg Ala Ala Gln 
            20                  25                  30          


Ser Pro Gly Pro Pro His Asn Gly Ser Ser Pro Gln Glu Leu Pro Arg 
        35                  40                  45              


Asn Ser Asn Asp Ala Pro Thr Pro Met Cys Thr Pro Ile Phe Trp Glu 
    50                  55                  60                  


Pro Pro Ala Ala Ser Leu Lys Pro Pro Ala Leu Leu Pro Pro Ser Ala 
65                  70                  75                  80  


Ser Arg Ala Ser Leu Asp Ser Gln Thr Ser Pro Asp Ser Pro Ser Ser 
                85                  90                  95      


Thr Pro Thr Pro Ser Pro Val Ser Arg Arg Ser Ala Ser Pro Glu Pro 
            100                 105                 110         


Ala Pro Arg Ser Pro Val Pro Pro Pro Lys Pro Ser Gly Ser Pro Cys 
        115                 120                 125             


Thr Pro Leu Leu Pro Met Ala Gly Val Leu Ala Gln Asn Gly Ser Ala 
    130                 135                 140                 


Ser Ala Pro Gly Thr Val Arg Arg Leu Ala Gly Arg Phe Glu Gly Gly 
145                 150                 155                 160 


Ala Glu Gly Arg Ala Gln Asp Ala Asp Ala Pro Glu Pro Gly Leu Gln 
                165                 170                 175     


Ala Arg Ala Asp Val Asn Gly Glu Arg Glu Ala Pro Leu Thr Gly Ser 
            180                 185                 190         


Gly Ser Gln Glu Asn Gly Ala Pro Asp Ala Gly Leu Ala Cys Pro Pro 
        195                 200                 205             


Cys Cys Pro Cys Val Cys His Thr Thr Arg Pro Gly Leu Glu Leu Arg 
    210                 215                 220                 


Trp Val Pro Val Gly Gly Tyr Glu Glu Val Pro Arg Val Pro Arg Arg 
225                 230                 235                 240 


Ala Ser Pro Leu Arg Thr Ser Arg Ser Arg Pro His Pro Pro Ser Ile 
                245                 250                 255     


Gly His Pro Ala Val Val Leu Thr Ser Tyr Arg Ser Thr Ala Glu Arg 
            260                 265                 270         


Lys Leu Leu Pro Leu Leu Lys Pro Pro Lys Pro Thr Arg Val Arg Gln 
        275                 280                 285             


Asp Ala Thr Ile Phe Gly Asp Pro Pro Gln Pro Asp Leu Asp Leu Leu 
    290                 295                 300                 


Ser Glu Asp Gly Ile Gln Thr Gly Asp Ser Pro Asp Glu Ala Pro Gln 
305                 310                 315                 320 


Asn Thr Pro Pro Ala Thr Val Glu Gly Arg Glu Glu Glu Gly Leu Glu 
                325                 330                 335     


Val Leu Lys Glu Gln Asn Trp Glu Leu Pro Leu Gln Asp Glu Pro Leu 
            340                 345                 350         


Tyr Gln Thr Tyr Arg Ala Ala Val Leu Ser Glu Glu Leu Trp Gly Val 
        355                 360                 365             


Gly Glu Asp Gly Ser Pro Ser Pro Ala Asn Ala Gly Asp Ala Pro Thr 
    370                 375                 380                 


Phe Pro Arg Pro Pro Gly Pro Arg Asn Thr Leu Trp Gln Glu Leu Pro 
385                 390                 395                 400 


Ala Val Gln Ala Ser Gly Leu Leu Asp Thr Leu Ser Pro Gln Glu Arg 
                405                 410                 415     


Arg Met Gln Glu Ser Leu Phe Glu Val Val Thr Ser Glu Ala Ser Tyr 
            420                 425                 430         


Leu Arg Ser Leu Arg Leu Leu Thr Asp Thr Phe Val Leu Ser Gln Ala 
        435                 440                 445             


Leu Arg Asp Thr Leu Thr Pro Arg Asp His His Thr Leu Phe Ser Asn 
    450                 455                 460                 


Val Gln Arg Val Gln Gly Val Ser Glu Arg Phe Leu Ala Thr Leu Leu 
465                 470                 475                 480 


Ser Arg Val Arg Ser Ser Pro His Ile Ser Asp Leu Cys Asp Val Val 
                485                 490                 495     


His Ala His Ala Val Gly Pro Phe Ser Val Tyr Val Asp Tyr Val Arg 
            500                 505                 510         


Asn Gln Gln Tyr Gln Glu Glu Thr Tyr Ser Arg Leu Met Asp Thr Asn 
        515                 520                 525             


Val Arg Phe Ser Ala Glu Leu Arg Arg Leu Gln Ser Leu Pro Lys Cys 
    530                 535                 540                 


Glu Arg Leu Pro Leu Pro Ser Phe Leu Leu Leu Pro Phe Gln Arg Ile 
545                 550                 555                 560 


Thr Arg Leu Arg Met Leu Leu Gln Asn Ile Leu Arg Gln Thr Glu Glu 
                565                 570                 575     


Gly Ser Ser Arg Gln Glu Asn Ala Gln Lys Ala Leu Gly Ala Val Ser 
            580                 585                 590         


Lys Ile Ile Glu Arg Cys Ser Ala Glu Val Gly Arg Met Lys Gln Thr 
        595                 600                 605             


Glu Glu Leu Ile Arg Leu Thr Gln Arg Leu Arg Phe His Lys Val Lys 
    610                 615                 620                 


Ala Leu Pro Leu Val Ser Trp Ser Arg Arg Leu Glu Phe Gln Gly Glu 
625                 630                 635                 640 


Leu Thr Glu Leu Gly Cys Arg Arg Gly Gly Val Leu Phe Ala Ser Arg 
                645                 650                 655     


Pro Arg Phe Thr Pro Leu Cys Leu Leu Leu Phe Ser Asp Leu Leu Leu 
            660                 665                 670         


Ile Thr Gln Pro Lys Ser Gly Gln Arg Leu Gln Val Leu Asp Tyr Ala 
        675                 680                 685             


His Arg Ser Leu Val Gln Ala Gln Gln Val Pro Asp Pro Ser Gly Pro 
    690                 695                 700                 


Pro Thr Phe Arg Leu Ser Leu Leu Ser Asn His Gln Gly Arg Pro Thr 
705                 710                 715                 720 


His Arg Leu Leu Gln Ala Ser Ser Leu Ser Asp Met Gln Arg Trp Leu 
                725                 730                 735     


Gly Ala Phe Pro Thr Pro Gly Pro Leu Pro Cys Ser Pro Asp Thr Ile 
            740                 745                 750         


Tyr Glu Asp Cys Asp Cys Ser Gln Glu Leu Cys Ser Glu Ser Ser Ala 
        755                 760                 765             


Pro Ala Lys Thr Glu Gly Arg Ser Leu Glu Ser Arg Ala Ala Pro Lys 
    770                 775                 780                 


His Leu His Lys Thr Pro Glu Gly Trp Leu Lys Gly Leu Pro Gly Ala 
785                 790                 795                 800 


Phe Pro Ala Gln Leu Val Cys Glu Val Thr Gly Glu His Glu Arg Arg 
                805                 810                 815     


Arg His Leu Arg Gln Asn Gln Arg Leu Leu Glu Ala Val Gly Ser Ser 
            820                 825                 830         


Ser Gly Thr Pro Asn Ala Pro Pro Pro 
        835                 840     


<210>  736
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF16__Homo_sapiens__XP_011539555

<400>  736

Met Ala Gln Arg His Ser Asp Ser Ser Leu Glu Glu Lys Leu Leu Gly 
1               5                   10                  15      


His Arg Phe His Ser Glu Leu Arg Leu Asp Ala Gly Gly Asn Pro Ala 
            20                  25                  30          


Ser Gly Leu Pro Met Val Arg Gly Ser Pro Arg Val Arg Asp Asp Ala 
        35                  40                  45              


Ala Phe Gln Pro Gln Val Pro Ala Pro Pro Gln Pro Arg Pro Pro Gly 
    50                  55                  60                  


His Glu Glu Pro Trp Pro Ile Val Leu Ser Thr Glu Ser Pro Ala Ala 
65                  70                  75                  80  


Leu Lys Leu Gly Thr Gln Gln Leu Ile Pro Lys Ser Leu Ala Val Ala 
                85                  90                  95      


Ser Lys Ala Lys Thr Pro Ala Arg His Gln Ser Phe Gly Ala Ala Val 
            100                 105                 110         


Leu Ser Arg Glu Ala Ala Arg Arg Asp Pro Lys Leu Leu Pro Ala Pro 
        115                 120                 125             


Ser Phe Ser Leu Asp Asp Met Asp Val Asp Lys Asp Pro Gly Gly Met 
    130                 135                 140                 


Leu Arg Arg Asn Leu Arg Asn Gln Ser Tyr Arg Ala Ala Met Lys Gly 
145                 150                 155                 160 


Leu Gly Lys Pro Gly Gly Gln Gly Asp Ala Ile Gln Leu Ser Pro Lys 
                165                 170                 175     


Leu Gln Ala Leu Ala Glu Glu Pro Ser Gln Pro His Thr Arg Ser Pro 
            180                 185                 190         


Ala Lys Asn Lys Lys Thr Leu Gly Arg Lys Arg Gly His Lys Gly Ser 
        195                 200                 205             


Phe Lys Asp Asp Pro Gln Leu Tyr Gln Glu Ile Gln Glu Arg Gly Leu 
    210                 215                 220                 


Asn Thr Ser Gln Glu Ser Asp Asp Asp Ile Leu Asp Glu Ser Ser Ser 
225                 230                 235                 240 


Pro Glu Gly Thr Gln Lys Val Asp Ala Thr Ile Val Val Lys Ser Tyr 
                245                 250                 255     


Arg Pro Ala Gln Val Thr Trp Ser Gln Leu Pro Glu Val Val Glu Leu 
            260                 265                 270         


Gly Ile Leu Asp Gln Leu Ser Thr Glu Glu Arg Lys Arg Gln Glu Ala 
        275                 280                 285             


Met Phe Glu Ile Leu Thr Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
    290                 295                 300                 


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Thr Val 
305                 310                 315                 320 


Thr Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
                325                 330                 335     


Gly Ala Ser Gln Arg Cys Leu Val Ala Gly Pro Glu Leu Trp Leu Gln 
            340                 345                 350         


Gly Leu Glu Val Glu Arg Leu Asp Met Gln Leu Gln Pro Cys Thr Gly 
        355                 360                 365             


Glu Ala Trp Leu Leu Arg Gly Trp Gln Ala Gln Ser Gly Pro Val Ser 
    370                 375                 380                 


Arg Gly Gly Gly Thr Pro Ala His Leu His Ala Gly Phe Phe Glu Asp 
385                 390                 395                 400 


Leu Glu Gln Arg His Lys Ala Gln Val Leu Val Glu Asp Ile Ser Asp 
                405                 410                 415     


Ile Leu Glu Glu His Ala Glu Lys His Phe His Pro Tyr Ile Ala Tyr 
            420                 425                 430         


Cys Ser Asn Glu Val Tyr Gln Gln Arg Thr Leu Gln Lys Leu Ile Ser 
        435                 440                 445             


Ser Asn Ala Ala Phe Arg Glu Ala Leu Arg Glu Ile Glu Arg Arg Pro 
    450                 455                 460                 


Ala Cys Gly Gly Leu Pro Met Leu Ser Phe Leu Ile Leu Pro Met Gln 
465                 470                 475                 480 


Arg Val Thr Arg Leu Pro Leu Leu Met Asp Thr Leu Cys Leu Lys Thr 
                485                 490                 495     


Gln Gly His Ser Glu Arg Tyr Lys Ala Ala Ser Arg Ala Leu Lys Ala 
            500                 505                 510         


Ile Ser Lys Leu Val Arg Gln Cys Asn Glu Gly Ala His Arg Met Glu 
        515                 520                 525             


Arg Met Glu Gln Met Tyr Thr Leu His Thr Gln Leu Asp Phe Ser Lys 
    530                 535                 540                 


Val Lys Ser Leu Pro Leu Ile Ser Ala Ser Arg Trp Leu Leu Lys Arg 
545                 550                 555                 560 


Gly Glu Leu Phe Leu Val Glu Glu Thr Gly Leu Phe Arg Lys Ile Ala 
                565                 570                 575     


Ser Arg Pro Thr Cys Tyr Leu Phe Leu Phe Asn Asp Val Leu Val Val 
            580                 585                 590         


Thr Lys Lys Lys Ser Glu Glu Ser Tyr Met Val Gln Asp Tyr Ala Gln 
        595                 600                 605             


Met Asn His Ile Gln Val Glu Lys Ile Glu Pro Ser Glu Leu Pro Leu 
    610                 615                 620                 


Pro Gly Gly Gly Asn Arg Ser Ser Ser Val Pro His Pro Phe Gln Val 
625                 630                 635                 640 


Thr Leu Leu Arg Asn Ser Glu Gly Arg Gln Glu Gln Leu Leu Leu Ser 
                645                 650                 655     


Ser Asp Ser Ala Ser Asp Arg Ala Arg Trp Ile Val Ala Leu Thr His 
            660                 665                 670         


Ser Glu Arg Gln Trp Gln Gly Leu Ser Ser Lys Gly Asp Leu Pro Gln 
        675                 680                 685             


Val Glu Ile Thr Lys Ala Phe Phe Ala Lys Gln Ala Asp Glu Val Thr 
    690                 695                 700                 


Leu Gln Gln Ala Asp Val Val Leu Val Leu Gln Gln Glu Asp Gly Trp 
705                 710                 715                 720 


Leu Tyr Gly Glu Arg Leu Arg Asp Gly Glu Thr Gly Trp Phe Pro Glu 
                725                 730                 735     


Asp Phe Ala Arg Phe Ile Thr Ser Arg Val Ala Val Glu Gly Asn Val 
            740                 745                 750         


Arg Arg Met Glu Arg Leu Arg Val Glu Thr Asp Val 
        755                 760                 


<210>  737
<211>  2063
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF17__Homo_sapiens__NP_055601

<400>  737

Met Ala Asp Gly Ala Pro Arg Pro Gln Leu Tyr Arg Ser Val Ser Phe 
1               5                   10                  15      


Lys Leu Leu Glu Arg Trp Ser Gly Gly Pro Gly Leu Arg Glu Glu Asp 
            20                  25                  30          


Thr Asp Thr Pro Gly Leu Arg Arg Arg Ala Ser Cys Arg Pro Thr Thr 
        35                  40                  45              


Ala Ala Arg Gly Gln Pro Ser Arg Arg Val Ser Lys Leu Ala Ser Gly 
    50                  55                  60                  


Pro Leu Ala Ala Pro Ala Gln Pro Arg Pro Leu Arg Ser Leu Ser Pro 
65                  70                  75                  80  


Ser Val Arg Gln Leu Ser Arg Arg Phe Asp Ala Pro Arg Leu Asp Asp 
                85                  90                  95      


Gly Ser Ala Gly Thr Arg Asp Gly Gly Val Leu Pro Ala Ala Ala Glu 
            100                 105                 110         


Glu Ala Ala Glu Gly Pro Ala Arg Gly Ala Trp Pro Ser Val Thr Glu 
        115                 120                 125             


Met Arg Lys Leu Phe Gly Gly Pro Gly Ser Arg Arg Pro Ser Ala Asp 
    130                 135                 140                 


Ser Glu Ser Pro Gly Thr Pro Ser Pro Asp Gly Ala Ala Trp Glu Pro 
145                 150                 155                 160 


Pro Ala Arg Glu Ser Arg Gln Pro Pro Thr Pro Pro Pro Arg Thr Cys 
                165                 170                 175     


Phe Pro Leu Ala Gly Leu Arg Ser Ala Arg Pro Leu Thr Gly Pro Glu 
            180                 185                 190         


Thr Glu Gly Arg Leu Arg Arg Pro Gln Gln Gln Gln Glu Arg Ala Gln 
        195                 200                 205             


Arg Pro Ala Asp Gly Leu His Ser Trp His Ile Phe Ser Gln Pro Gln 
    210                 215                 220                 


Ala Gly Ala Arg Ala Ser Cys Ser Ser Ser Ser Ile Ala Ala Ser Tyr 
225                 230                 235                 240 


Pro Val Ser Arg Ser Arg Ala Ala Ser Ser Ser Glu Glu Glu Glu Glu 
                245                 250                 255     


Gly Pro Pro Gln Leu Pro Gly Ala Gln Ser Pro Ala Tyr His Gly Gly 
            260                 265                 270         


His Ser Ser Gly Ser Asp Asp Asp Arg Asp Gly Glu Gly Gly His Arg 
        275                 280                 285             


Trp Gly Gly Arg Pro Gly Leu Arg Pro Gly Ser Ser Leu Leu Asp Gln 
    290                 295                 300                 


Asp Cys Arg Pro Asp Ser Asp Gly Leu Asn Leu Ser Ser Met Asn Ser 
305                 310                 315                 320 


Ala Gly Val Ser Gly Ser Pro Glu Pro Pro Thr Ser Pro Arg Ala Pro 
                325                 330                 335     


Arg Glu Glu Gly Leu Arg Glu Trp Gly Ser Gly Ser Pro Pro Cys Val 
            340                 345                 350         


Pro Gly Pro Gln Glu Gly Leu Arg Pro Met Ser Asp Ser Val Gly Gly 
        355                 360                 365             


Ala Phe Arg Val Ala Lys Val Ser Phe Pro Ser Tyr Leu Ala Ser Pro 
    370                 375                 380                 


Ala Gly Ser Arg Gly Ser Ser Arg Tyr Ser Ser Thr Glu Thr Leu Lys 
385                 390                 395                 400 


Asp Asp Asp Leu Trp Ser Ser Arg Gly Ser Gly Gly Trp Gly Val Tyr 
                405                 410                 415     


Arg Ser Pro Ser Phe Gly Ala Gly Glu Gly Leu Leu Arg Ser Gln Ala 
            420                 425                 430         


Arg Thr Arg Ala Lys Gly Pro Gly Gly Thr Ser Arg Ala Leu Arg Asp 
        435                 440                 445             


Gly Gly Phe Glu Pro Glu Lys Ser Arg Gln Arg Lys Ser Leu Ser Asn 
    450                 455                 460                 


Pro Asp Ile Ala Ser Glu Thr Leu Thr Leu Leu Ser Phe Leu Arg Ser 
465                 470                 475                 480 


Asp Leu Ser Glu Leu Arg Val Arg Lys Pro Gly Gly Ser Ser Gly Asp 
                485                 490                 495     


Arg Gly Ser Asn Pro Leu Asp Gly Arg Asp Ser Pro Ser Ala Gly Gly 
            500                 505                 510         


Pro Val Gly Gln Leu Glu Pro Ile Pro Ile Pro Ala Pro Ala Ser Pro 
        515                 520                 525             


Gly Thr Arg Pro Thr Leu Lys Asp Leu Thr Ala Thr Leu Arg Arg Ala 
    530                 535                 540                 


Lys Ser Phe Thr Cys Ser Glu Lys Pro Met Ala Arg Arg Leu Pro Arg 
545                 550                 555                 560 


Thr Ser Ala Leu Lys Ser Ser Ser Ser Glu Leu Leu Leu Thr Gly Pro 
                565                 570                 575     


Gly Ala Glu Glu Asp Pro Leu Pro Leu Ile Val Gln Asp Gln Tyr Val 
            580                 585                 590         


Gln Glu Ala Arg Gln Val Phe Glu Lys Ile Gln Arg Met Gly Ala Gln 
        595                 600                 605             


Gln Asp Asp Gly Ser Asp Ala Pro Pro Gly Ser Pro Asp Trp Ala Gly 
    610                 615                 620                 


Asp Val Thr Arg Gly Gln Arg Ser Gln Glu Glu Leu Ser Gly Pro Glu 
625                 630                 635                 640 


Ser Ser Leu Thr Asp Glu Gly Ile Gly Ala Asp Pro Glu Pro Pro Val 
                645                 650                 655     


Ala Ala Phe Cys Gly Leu Gly Thr Thr Gly Met Trp Arg Pro Leu Ser 
            660                 665                 670         


Ser Ser Ser Ala Gln Thr Asn His His Gly Pro Gly Thr Glu Asp Ser 
        675                 680                 685             


Leu Gly Gly Trp Ala Leu Val Ser Pro Glu Thr Pro Pro Thr Pro Gly 
    690                 695                 700                 


Ala Leu Arg Arg Arg Arg Lys Val Pro Pro Ser Gly Ser Gly Gly Ser 
705                 710                 715                 720 


Glu Leu Ser Asn Gly Glu Ala Gly Glu Ala Tyr Arg Ser Leu Ser Asp 
                725                 730                 735     


Pro Ile Pro Gln Arg His Arg Ala Ala Thr Ser Glu Glu Pro Thr Gly 
            740                 745                 750         


Phe Ser Val Asp Ser Asn Leu Leu Gly Ser Leu Ser Pro Lys Thr Gly 
        755                 760                 765             


Leu Pro Ala Thr Ser Ala Met Asp Glu Gly Leu Thr Ser Gly His Ser 
    770                 775                 780                 


Asp Trp Ser Val Gly Ser Glu Glu Ser Lys Gly Tyr Gln Glu Val Ile 
785                 790                 795                 800 


Gln Ser Ile Val Gln Gly Pro Gly Thr Leu Gly Arg Val Val Asp Asp 
                805                 810                 815     


Arg Ile Ala Gly Lys Ala Pro Lys Lys Lys Ser Leu Ser Asp Pro Ser 
            820                 825                 830         


Arg Arg Gly Glu Leu Ala Gly Pro Gly Phe Glu Gly Pro Gly Gly Glu 
        835                 840                 845             


Pro Ile Arg Glu Val Glu Pro Met Leu Pro Pro Ser Ser Ser Glu Pro 
    850                 855                 860                 


Ile Leu Val Glu Gln Arg Ala Glu Pro Glu Glu Pro Gly Ala Thr Arg 
865                 870                 875                 880 


Ser Arg Ala Gln Ser Glu Arg Ala Leu Pro Glu Ala Leu Pro Pro Pro 
                885                 890                 895     


Ala Thr Ala His Arg Asn Phe His Leu Asp Pro Lys Leu Ala Asp Ile 
            900                 905                 910         


Leu Ser Pro Arg Leu Ile Arg Arg Gly Ser Lys Lys Arg Pro Ala Arg 
        915                 920                 925             


Ser Ser His Gln Glu Leu Arg Arg Asp Glu Gly Ser Gln Asp Gln Thr 
    930                 935                 940                 


Gly Ser Leu Ser Arg Ala Arg Pro Ser Ser Arg His Val Arg His Ala 
945                 950                 955                 960 


Ser Val Pro Ala Thr Phe Met Pro Ile Val Val Pro Glu Pro Pro Thr 
                965                 970                 975     


Ser Val Gly Pro Pro Val Ala Val Pro Glu Pro Ile Gly Phe Pro Thr 
            980                 985                 990         


Arg Ala His Pro Thr Leu Gln Ala  Pro Ser Leu Glu Asp  Val Thr Lys 
        995                 1000                 1005             


Gln Tyr  Met Leu Asn Leu His  Ser Gly Glu Val Pro  Ala Pro Val 
    1010                 1015                 1020             


Pro Val  Asp Met Pro Cys Leu  Pro Leu Ala Ala Pro  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ala  Lys Pro Pro Glu Ala  Ala Arg Pro Ala Asp  Glu Pro Thr 
    1040                 1045                 1050             


Pro Ala  Ser Lys Cys Cys Ser  Lys Pro Gln Val Asp  Met Arg Lys 
    1055                 1060                 1065             


His Val  Ala Met Thr Leu Leu  Asp Thr Glu Gln Ser  Tyr Val Glu 
    1070                 1075                 1080             


Ser Leu  Arg Thr Leu Met Gln  Gly Tyr Met Gln Pro  Leu Lys Gln 
    1085                 1090                 1095             


Pro Glu  Asn Ser Val Leu Cys  Asp Pro Ser Leu Val  Asp Glu Ile 
    1100                 1105                 1110             


Phe Asp  Gln Ile Pro Glu Leu  Leu Glu His His Glu  Gln Phe Leu 
    1115                 1120                 1125             


Glu Gln  Val Arg His Cys Met  Gln Thr Trp His Ala  Gln Gln Lys 
    1130                 1135                 1140             


Val Gly  Ala Leu Leu Val Gln  Ser Phe Ser Lys Asp  Val Leu Val 
    1145                 1150                 1155             


Asn Ile  Tyr Ser Ala Tyr Ile  Asp Asn Phe Leu Asn  Ala Lys Asp 
    1160                 1165                 1170             


Ala Val  Arg Val Ala Lys Glu  Ala Arg Pro Ala Phe  Leu Lys Phe 
    1175                 1180                 1185             


Leu Glu  Gln Ser Met Arg Glu  Asn Lys Glu Lys Gln  Ala Leu Ser 
    1190                 1195                 1200             


Asp Leu  Met Ile Lys Pro Val  Gln Arg Ile Pro Arg  Tyr Glu Leu 
    1205                 1210                 1215             


Leu Val  Lys Asp Leu Leu Lys  His Thr Pro Glu Asp  His Pro Asp 
    1220                 1225                 1230             


His Pro  Leu Leu Leu Glu Ala  Gln Arg Asn Ile Lys  Gln Val Ala 
    1235                 1240                 1245             


Glu Arg  Ile Asn Lys Gly Val  Arg Ser Ala Glu Glu  Ala Glu Arg 
    1250                 1255                 1260             


His Ala  Arg Val Leu Gln Glu  Ile Glu Ala His Ile  Glu Gly Met 
    1265                 1270                 1275             


Glu Asp  Leu Gln Ala Pro Leu  Arg Arg Phe Leu Arg  Gln Glu Met 
    1280                 1285                 1290             


Val Ile  Glu Val Lys Ala Ile  Gly Gly Lys Lys Asp  Arg Ser Leu 
    1295                 1300                 1305             


Phe Leu  Phe Thr Asp Leu Ile  Val Cys Thr Thr Leu  Lys Arg Lys 
    1310                 1315                 1320             


Ser Gly  Ser Leu Arg Arg Ser  Ser Met Ser Leu Tyr  Thr Ala Ala 
    1325                 1330                 1335             


Ser Val  Ile Asp Thr Ala Ser  Lys Tyr Lys Met Leu  Trp Lys Leu 
    1340                 1345                 1350             


Pro Leu  Glu Asp Ala Asp Ile  Ile Lys Gly Ala Ser  Gln Ala Thr 
    1355                 1360                 1365             


Asn Arg  Glu Asn Ile Gln Lys  Ala Ile Ser Arg Leu  Asp Glu Asp 
    1370                 1375                 1380             


Leu Thr  Thr Leu Gly Gln Met  Ser Lys Leu Ser Glu  Ser Leu Gly 
    1385                 1390                 1395             


Phe Pro  His Gln Ser Leu Asp  Asp Ala Leu Arg Asp  Leu Ser Ala 
    1400                 1405                 1410             


Ala Met  His Arg Asp Leu Ser  Glu Lys Gln Ala Leu  Cys Tyr Ala 
    1415                 1420                 1425             


Leu Ser  Phe Pro Pro Thr Lys  Leu Glu Leu Cys Ala  Thr Arg Pro 
    1430                 1435                 1440             


Glu Gly  Thr Asp Ser Tyr Ile  Phe Glu Phe Pro His  Pro Asp Ala 
    1445                 1450                 1455             


Arg Leu  Gly Phe Glu Gln Ala  Phe Asp Glu Ala Lys  Arg Lys Leu 
    1460                 1465                 1470             


Ala Ser  Ser Lys Ser Cys Leu  Asp Pro Glu Phe Leu  Lys Ala Ile 
    1475                 1480                 1485             


Pro Ile  Met Lys Thr Arg Ser  Gly Met Gln Phe Ser  Cys Ala Ala 
    1490                 1495                 1500             


Pro Thr  Leu Asn Ser Cys Pro  Glu Pro Ser Pro Glu  Val Trp Val 
    1505                 1510                 1515             


Cys Asn  Ser Asp Gly Tyr Val  Gly Gln Val Cys Leu  Leu Ser Leu 
    1520                 1525                 1530             


Arg Ala  Glu Pro Asp Val Glu  Ala Cys Ile Ala Val  Cys Ser Ala 
    1535                 1540                 1545             


Arg Ile  Leu Cys Ile Gly Ala  Val Pro Gly Leu Gln  Pro Arg Cys 
    1550                 1555                 1560             


His Arg  Glu Pro Pro Pro Ser  Leu Arg Ser Pro Pro  Glu Thr Ala 
    1565                 1570                 1575             


Pro Glu  Pro Ala Gly Pro Glu  Leu Asp Val Glu Ala  Ala Ala Asp 
    1580                 1585                 1590             


Glu Glu  Ala Ala Thr Leu Ala  Glu Pro Gly Pro Gln  Pro Cys Leu 
    1595                 1600                 1605             


His Ile  Ser Ile Ala Gly Ser  Gly Leu Glu Met Thr  Pro Gly Leu 
    1610                 1615                 1620             


Gly Glu  Gly Asp Pro Arg Pro  Glu Leu Val Pro Phe  Asp Ser Asp 
    1625                 1630                 1635             


Ser Asp  Asp Glu Ser Ser Pro  Ser Pro Ser Gly Thr  Leu Gln Ser 
    1640                 1645                 1650             


Gln Ala  Ser Arg Ser Thr Ile  Ser Ser Ser Phe Gly  Asn Glu Glu 
    1655                 1660                 1665             


Thr Pro  Ser Ser Lys Glu Ala  Thr Ala Glu Thr Thr  Ser Ser Glu 
    1670                 1675                 1680             


Glu Glu  Gln Glu Pro Gly Phe  Leu Pro Leu Ser Gly  Ser Phe Gly 
    1685                 1690                 1695             


Pro Gly  Gly Pro Cys Gly Thr  Ser Pro Met Asp Gly  Arg Ala Leu 
    1700                 1705                 1710             


Arg Arg  Ser Ser His Gly Ser  Phe Thr Arg Gly Ser  Leu Glu Asp 
    1715                 1720                 1725             


Leu Leu  Ser Val Asp Pro Glu  Ala Tyr Gln Ser Ser  Val Trp Leu 
    1730                 1735                 1740             


Gly Thr  Glu Asp Gly Cys Val  His Val Tyr Gln Ser  Ser Asp Ser 
    1745                 1750                 1755             


Ile Arg  Asp Arg Arg Asn Ser  Met Lys Leu Gln His  Ala Ala Ser 
    1760                 1765                 1770             


Val Thr  Cys Ile Leu Tyr Leu  Asn Asn Gln Val Phe  Val Ser Leu 
    1775                 1780                 1785             


Ala Asn  Gly Glu Leu Val Val  Tyr Gln Arg Glu Ala  Gly His Phe 
    1790                 1795                 1800             


Trp Asp  Pro Gln Asn Phe Lys  Ser Val Thr Leu Gly  Thr Gln Gly 
    1805                 1810                 1815             


Ser Pro  Ile Thr Lys Met Val  Ser Val Gly Gly Arg  Leu Trp Cys 
    1820                 1825                 1830             


Gly Cys  Gln Asn Arg Val Leu  Val Leu Ser Pro Asp  Thr Leu Gln 
    1835                 1840                 1845             


Leu Glu  His Met Phe Tyr Val  Gly Gln Asp Ser Ser  Arg Cys Val 
    1850                 1855                 1860             


Ala Cys  Met Val Asp Ser Ser  Leu Gly Val Trp Val  Thr Leu Lys 
    1865                 1870                 1875             


Gly Ser  Ala His Val Cys Leu  Tyr His Pro Asp Thr  Phe Glu Gln 
    1880                 1885                 1890             


Leu Ala  Glu Val Asp Val Thr  Pro Pro Val His Arg  Met Leu Ala 
    1895                 1900                 1905             


Gly Ser  Asp Ala Ile Ile Arg  Gln His Lys Ala Ala  Cys Leu Arg 
    1910                 1915                 1920             


Ile Thr  Ala Leu Leu Val Cys  Glu Glu Leu Leu Trp  Val Gly Thr 
    1925                 1930                 1935             


Ser Ala  Gly Val Val Leu Thr  Met Pro Thr Ser Pro  Gly Thr Val 
    1940                 1945                 1950             


Ser Cys  Pro Arg Ala Pro Leu  Ser Pro Thr Gly Leu  Gly Gln Gly 
    1955                 1960                 1965             


His Thr  Gly His Val Arg Phe  Leu Ala Ala Val Gln  Leu Pro Asp 
    1970                 1975                 1980             


Gly Phe  Asn Leu Leu Cys Pro  Thr Pro Pro Pro Pro  Pro Asp Thr 
    1985                 1990                 1995             


Gly Pro  Glu Lys Leu Pro Ser  Leu Glu His Arg Asp  Ser Pro Trp 
    2000                 2005                 2010             


His Arg  Gly Pro Ala Pro Ala  Arg Pro Lys Met Leu  Val Ile Ser 
    2015                 2020                 2025             


Gly Gly  Asp Gly Tyr Glu Asp  Phe Arg Leu Ser Ser  Gly Gly Gly 
    2030                 2035                 2040             


Ser Ser  Ser Glu Thr Val Gly  Arg Asp Asp Ser Thr  Asn His Leu 
    2045                 2050                 2055             


Leu Leu  Trp Arg Val 
    2060             


<210>  738
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF1__Homo_sapiens__NP_945328

<400>  738

Met Glu Asp Phe Ala Arg Gly Ala Ala Ser Pro Gly Pro Ser Arg Pro 
1               5                   10                  15      


Gly Leu Val Pro Val Ser Ile Ile Gly Ala Glu Asp Glu Asp Phe Glu 
            20                  25                  30          


Asn Glu Leu Glu Thr Asn Ser Glu Glu Gln Asn Ser Gln Phe Gln Ser 
        35                  40                  45              


Leu Glu Gln Val Lys Arg Arg Pro Ala His Leu Met Ala Leu Leu Gln 
    50                  55                  60                  


His Val Ala Leu Gln Phe Glu Pro Gly Pro Leu Val Leu Arg Val Pro 
65                  70                  75                  80  


Val Pro Pro Asn Val Ala Phe Glu Leu Asp Arg Thr Arg Ala Asp Leu 
                85                  90                  95      


Ile Ser Glu Asp Val Gln Arg Arg Phe Val Gln Glu Val Val Gln Ser 
            100                 105                 110         


Gln Gln Val Ala Val Gly Arg Gln Leu Glu Asp Phe Arg Ser Lys Arg 
        115                 120                 125             


Leu Met Gly Met Thr Pro Trp Glu Gln Glu Leu Ala Gln Leu Glu Ala 
    130                 135                 140                 


Trp Val Gly Arg Asp Arg Ala Ser Tyr Glu Ala Arg Glu Arg His Val 
145                 150                 155                 160 


Ala Glu Arg Leu Leu Met His Leu Glu Glu Met Gln His Thr Ile Ser 
                165                 170                 175     


Thr Asp Glu Glu Lys Ser Ala Ala Val Val Asn Ala Ile Gly Leu Tyr 
            180                 185                 190         


Met Arg His Leu Gly Val Arg Thr Lys Ser Gly Asp Lys Lys Ser Gly 
        195                 200                 205             


Arg Asn Phe Phe Arg Lys Lys Val Met Gly Asn Arg Arg Ser Asp Glu 
    210                 215                 220                 


Pro Ala Lys Thr Lys Lys Gly Leu Ser Ser Ile Leu Asp Ala Ala Arg 
225                 230                 235                 240 


Trp Asn Arg Gly Glu Pro Gln Val Pro Asp Phe Arg His Leu Lys Ala 
                245                 250                 255     


Glu Val Asp Ala Glu Lys Pro Gly Ala Thr Asp Arg Lys Gly Gly Val 
            260                 265                 270         


Gly Met Pro Ser Arg Asp Arg Asn Ile Gly Ala Pro Gly Gln Asp Thr 
        275                 280                 285             


Pro Gly Val Ser Leu His Pro Leu Ser Leu Asp Ser Pro Asp Arg Glu 
    290                 295                 300                 


Pro Gly Ala Asp Ala Pro Leu Glu Leu Gly Asp Ser Ser Pro Gln Gly 
305                 310                 315                 320 


Pro Met Ser Leu Glu Ser Leu Ala Pro Pro Glu Ser Thr Asp Glu Gly 
                325                 330                 335     


Ala Glu Thr Glu Ser Pro Glu Pro Gly Asp Glu Gly Glu Pro Gly Arg 
            340                 345                 350         


Ser Gly Leu Glu Leu Glu Pro Glu Glu Pro Pro Gly Trp Arg Glu Leu 
        355                 360                 365             


Val Pro Pro Asp Thr Leu His Ser Leu Pro Lys Ser Gln Val Lys Arg 
    370                 375                 380                 


Gln Glu Val Ile Ser Glu Leu Leu Val Thr Glu Ala Ala His Val Arg 
385                 390                 395                 400 


Met Leu Arg Val Leu His Asp Leu Phe Phe Gln Pro Met Ala Glu Cys 
                405                 410                 415     


Leu Phe Phe Pro Leu Glu Glu Leu Gln Asn Ile Phe Pro Ser Leu Asp 
            420                 425                 430         


Glu Leu Ile Glu Val His Ser Leu Phe Leu Asp Arg Leu Met Lys Arg 
        435                 440                 445             


Arg Gln Glu Ser Gly Tyr Leu Ile Glu Glu Ile Gly Asp Val Leu Leu 
    450                 455                 460                 


Ala Arg Phe Asp Gly Ala Glu Gly Ser Trp Phe Gln Lys Ile Ser Ser 
465                 470                 475                 480 


Arg Phe Cys Ser Arg Gln Ser Phe Ala Leu Glu Gln Leu Lys Ala Lys 
                485                 490                 495     


Gln Arg Lys Asp Pro Arg Phe Cys Ala Phe Val Gln Glu Ala Glu Ser 
            500                 505                 510         


Arg Pro Arg Cys Arg Arg Leu Gln Leu Lys Asp Met Ile Pro Thr Glu 
        515                 520                 525             


Met Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu Gln Ser Ile Gly Gln 
    530                 535                 540                 


Asn Thr Glu Glu Pro Thr Glu Arg Glu Lys Val Glu Leu Ala Ala Glu 
545                 550                 555                 560 


Cys Cys Arg Glu Ile Leu His His Val Asn Gln Ala Val Arg Asp Met 
                565                 570                 575     


Glu Asp Leu Leu Arg Leu Lys Asp Tyr Gln Arg Arg Leu Asp Leu Ser 
            580                 585                 590         


His Leu Arg Gln Ser Ser Asp Pro Met Leu Ser Glu Phe Lys Asn Leu 
        595                 600                 605             


Asp Ile Thr Lys Lys Lys Leu Val His Glu Gly Pro Leu Thr Trp Arg 
    610                 615                 620                 


Val Thr Lys Asp Lys Ala Val Glu Val His Val Leu Leu Leu Asp Asp 
625                 630                 635                 640 


Leu Leu Leu Leu Leu Gln Arg Gln Asp Glu Arg Leu Leu Leu Lys Ser 
                645                 650                 655     


His Ser Arg Thr Leu Thr Pro Thr Pro Asp Gly Lys Thr Met Leu Arg 
            660                 665                 670         


Pro Val Leu Arg Leu Thr Ser Ala Met Thr Arg Glu Val Ala Thr Asp 
        675                 680                 685             


His Lys Ala Phe Tyr Val Leu Phe Thr Trp Asp Gln Glu Ala Gln Ile 
    690                 695                 700                 


Tyr Glu Leu Val Ala Gln Thr Val Ser Glu Arg Lys Asn Trp Cys Ala 
705                 710                 715                 720 


Leu Ile Thr Glu Thr Ala Gly Ser Leu Lys Val Pro Ala Pro Ala Ser 
                725                 730                 735     


Arg Pro Lys Pro Arg Pro Ser Pro Ser Ser Thr Arg Glu Pro Leu Leu 
            740                 745                 750         


Ser Ser Ser Glu Asn Gly Asn Gly Gly Arg Glu Thr Ser Pro Ala Asp 
        755                 760                 765             


Ala Arg Thr Glu Arg Ile Leu Ser Asp Leu Leu Pro Phe Cys Arg Pro 
    770                 775                 780                 


Gly Pro Glu Gly Gln Leu Ala Ala Thr Ala Leu Arg Lys Val Leu Ser 
785                 790                 795                 800 


Leu Lys Gln Leu Leu Phe Pro Ala Glu Glu Asp Asn Gly Ala Gly Pro 
                805                 810                 815     


Pro Arg Asp Gly Asp Gly Val Pro Gly Gly Gly Pro Leu Ser Pro Ala 
            820                 825                 830         


Arg Thr Gln Glu Ile Gln Glu Asn Leu Leu Ser Leu Glu Glu Thr Met 
        835                 840                 845             


Lys Gln Leu Glu Glu Leu Glu Glu Glu Phe Cys Arg Leu Arg Pro Leu 
    850                 855                 860                 


Leu Ser Gln Leu Gly Gly Asn Ser Val Pro Gln Pro Gly Cys Thr 
865                 870                 875                 


<210>  739
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF25__Homo_sapiens__NP_001104740

<400>  739

Met Lys Pro Pro Asp Arg Pro Ala Pro Gly Arg Thr Asp Arg Ile Leu 
1               5                   10                  15      


Gly Val Met Gly Gly Met Leu Arg Ala Cys Ala Leu Pro Gly Gln Glu 
            20                  25                  30          


Gly Pro Pro Arg Arg Ser Pro Leu Gly Leu Val Gly Thr Glu Pro Glu 
        35                  40                  45              


Ser Glu Arg Thr Glu Gly Asp His Arg Arg Asp Arg Glu His Glu Val 
    50                  55                  60                  


Leu Ala Gly Ala Leu Gln Pro Glu Ser Tyr Ser Ile Ala Gly Ser Glu 
65                  70                  75                  80  


Gly Ser Ile Ser Ala Ser Ala Ala Ser Gly Leu Ala Ala Pro Ser Gly 
                85                  90                  95      


Pro Ser Ser Gly Leu Ser Ser Gly Pro Cys Ser Pro Gly Pro Pro Gly 
            100                 105                 110         


Pro Val Ser Gly Leu Arg Arg Trp Leu Asp His Ser Lys His Cys Leu 
        115                 120                 125             


Ser Val Glu Thr Glu Ala Asp Ser Gly Gln Ala Gly Pro Tyr Glu Asn 
    130                 135                 140                 


Trp Met Leu Glu Pro Ala Leu Ala Thr Gly Glu Glu Leu Pro Glu Leu 
145                 150                 155                 160 


Thr Leu Leu Thr Thr Leu Leu Glu Gly Pro Gly Asp Lys Thr Gln Pro 
                165                 170                 175     


Pro Glu Glu Glu Thr Leu Ser Gln Ala Pro Glu Ser Glu Glu Glu Gln 
            180                 185                 190         


Lys Lys Lys Ala Leu Glu Arg Ser Met Tyr Val Leu Ser Glu Leu Val 
        195                 200                 205             


Glu Thr Glu Lys Met Tyr Val Asp Asp Leu Gly Gln Ile Val Glu Gly 
    210                 215                 220                 


Tyr Met Ala Thr Met Ala Ala Gln Gly Val Pro Glu Ser Leu Arg Gly 
225                 230                 235                 240 


Arg Asp Arg Ile Val Phe Gly Asn Ile Gln Gln Ile Tyr Glu Trp His 
                245                 250                 255     


Arg Asp Tyr Phe Leu Gln Glu Leu Gln Arg Cys Leu Lys Asp Pro Asp 
            260                 265                 270         


Trp Leu Ala Gln Leu Phe Ile Lys His Glu Arg Arg Leu His Met Tyr 
        275                 280                 285             


Val Val Tyr Cys Gln Asn Lys Pro Lys Ser Glu His Val Val Ser Glu 
    290                 295                 300                 


Phe Gly Asp Ser Tyr Phe Glu Glu Leu Arg Gln Gln Leu Gly His Arg 
305                 310                 315                 320 


Leu Gln Leu Asn Asp Leu Leu Ile Lys Pro Val Gln Arg Ile Met Lys 
                325                 330                 335     


Tyr Gln Leu Leu Leu Lys Asp Phe Leu Lys Tyr Tyr Asn Arg Ala Gly 
            340                 345                 350         


Met Asp Thr Ala Asp Leu Glu Gln Ala Val Glu Val Met Cys Phe Val 
        355                 360                 365             


Pro Lys Arg Cys Asn Asp Met Met Thr Leu Gly Arg Leu Arg Gly Phe 
    370                 375                 380                 


Glu Gly Lys Leu Thr Ala Gln Gly Lys Leu Leu Gly Gln Asp Thr Phe 
385                 390                 395                 400 


Trp Val Thr Glu Pro Glu Ala Gly Gly Leu Leu Ser Ser Arg Gly Arg 
                405                 410                 415     


Glu Arg Arg Val Phe Leu Phe Glu Gln Ile Ile Ile Phe Ser Glu Ala 
            420                 425                 430         


Leu Gly Gly Gly Val Arg Gly Gly Thr Gln Pro Gly Tyr Val Tyr Lys 
        435                 440                 445             


Asn Ser Ile Lys Val Ser Cys Leu Gly Leu Glu Gly Asn Leu Gln Gly 
    450                 455                 460                 


Asp Pro Cys Arg Phe Ala Leu Thr Ser Arg Gly Pro Glu Gly Gly Ile 
465                 470                 475                 480 


Gln Arg Tyr Val Leu Gln Ala Ala Asp Pro Ala Ile Ser Gln Ala Trp 
                485                 490                 495     


Ile Lys His Val Ala Gln Ile Leu Glu Ser Gln Arg Asp Phe Leu Asn 
            500                 505                 510         


Ala Leu Gln Ser Pro Ile Glu Tyr Gln Arg Arg Glu Ser Gln Thr Asn 
        515                 520                 525             


Ser Leu Gly Arg Pro Arg Gly Pro Gly Val Gly Ser Pro Gly Arg Ile 
    530                 535                 540                 


Arg Leu Gly Asp Gln Ala Gln Gly Ser Thr His Thr Pro Ile Asn Gly 
545                 550                 555                 560 


Ser Leu Pro Ser Leu Leu Leu Ser Pro Lys Gly Glu Val Ala Arg Ala 
                565                 570                 575     


Leu Leu Pro Leu Asp Lys Gln Ala Leu Gly Asp Ile Pro Gln Ala Pro 
            580                 585                 590         


His Asp Ser Pro Pro Val Ser Pro Thr Pro Lys Thr Pro Pro Cys Gln 
        595                 600                 605             


Ala Arg Leu Ala Lys Leu Asp Glu Asp Glu Leu 
    610                 615                 


<210>  740
<211>  791
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF26__Homo_sapiens__NP_001238892

<400>  740

Met Asp Gly Glu Ser Glu Val Asp Phe Ser Ser Asn Ser Ile Thr Pro 
1               5                   10                  15      


Leu Trp Arg Arg Arg Ser Ile Pro Gln Pro His Gln Val Leu Gly Arg 
            20                  25                  30          


Ser Lys Pro Arg Pro Gln Ser Tyr Gln Ser Pro Asn Gly Leu Leu Ile 
        35                  40                  45              


Thr Asp Phe Pro Val Glu Asp Gly Gly Thr Leu Leu Ala Ala Gln Ile 
    50                  55                  60                  


Pro Ala Gln Val Pro Thr Ala Ser Asp Ser Arg Thr Val His Arg Ser 
65                  70                  75                  80  


Pro Leu Leu Leu Gly Ala Gln Arg Arg Ala Val Ala Asn Gly Gly Thr 
                85                  90                  95      


Ala Ser Pro Glu Tyr Arg Ala Ala Ser Pro Arg Leu Arg Arg Pro Lys 
            100                 105                 110         


Ser Pro Lys Leu Pro Lys Ala Val Pro Gly Gly Ser Pro Lys Ser Pro 
        115                 120                 125             


Ala Asn Gly Ala Val Thr Leu Pro Ala Pro Pro Pro Pro Pro Val Leu 
    130                 135                 140                 


Arg Pro Pro Arg Thr Pro Asn Ala Pro Ala Pro Cys Thr Pro Glu Glu 
145                 150                 155                 160 


Asp Leu Thr Gly Leu Thr Ala Ser Pro Val Pro Ser Pro Thr Ala Asn 
                165                 170                 175     


Gly Leu Ala Ala Asn Asn Asp Ser Pro Gly Ser Gly Ser Gln Ser Gly 
            180                 185                 190         


Arg Lys Ala Lys Asp Pro Glu Arg Gly Leu Phe Pro Gly Pro Gln Lys 
        195                 200                 205             


Ser Ser Ser Glu Gln Lys Leu Pro Leu Gln Arg Leu Pro Ser Gln Glu 
    210                 215                 220                 


Asn Glu Leu Leu Glu Asn Pro Ser Val Val Leu Ser Thr Asn Ser Pro 
225                 230                 235                 240 


Ala Ala Leu Lys Val Gly Lys Gln Gln Ile Ile Pro Lys Ser Leu Ala 
                245                 250                 255     


Ser Glu Ile Lys Ile Ser Lys Ser Asn Asn Gln Asn Val Glu Pro His 
            260                 265                 270         


Lys Arg Leu Leu Lys Val Arg Ser Met Val Glu Gly Leu Gly Gly Pro 
        275                 280                 285             


Leu Gly His Ala Gly Glu Glu Ser Glu Val Asp Asn Asp Val Asp Ser 
    290                 295                 300                 


Pro Gly Ser Leu Arg Arg Gly Leu Arg Ser Thr Ser Tyr Arg Arg Ala 
305                 310                 315                 320 


Val Val Ser Gly Phe Asp Phe Asp Ser Pro Thr Ser Ser Lys Lys Lys 
                325                 330                 335     


Asn Arg Met Ser Gln Pro Val Leu Lys Val Val Met Glu Asp Lys Glu 
            340                 345                 350         


Lys Phe Ser Ser Leu Gly Arg Ile Lys Lys Lys Met Leu Lys Gly Gln 
        355                 360                 365             


Gly Thr Phe Asp Gly Glu Glu Asn Ala Val Leu Tyr Gln Asn Tyr Lys 
    370                 375                 380                 


Glu Lys Ala Leu Asp Ile Asp Ser Asp Glu Glu Ser Glu Pro Lys Glu 
385                 390                 395                 400 


Gln Lys Ser Asp Glu Lys Ile Val Ile His His Lys Pro Leu Arg Ser 
                405                 410                 415     


Thr Trp Ser Gln Leu Ser Ala Val Lys Arg Lys Gly Leu Ser Gln Thr 
            420                 425                 430         


Val Ser Gln Glu Glu Arg Lys Arg Gln Glu Ala Ile Phe Glu Val Ile 
        435                 440                 445             


Ser Ser Glu His Ser Tyr Leu Leu Ser Leu Glu Ile Leu Ile Arg Met 
    450                 455                 460                 


Phe Lys Asn Ser Lys Glu Leu Ser Asp Thr Met Thr Lys Thr Glu Arg 
465                 470                 475                 480 


His His Leu Phe Ser Asn Ile Thr Asp Val Cys Glu Ala Ser Lys Lys 
                485                 490                 495     


Phe Phe Ile Glu Leu Glu Ala Arg His Gln Asn Asn Ile Phe Ile Asp 
            500                 505                 510         


Asp Ile Ser Asp Ile Val Glu Lys His Thr Ala Ser Thr Phe Asp Pro 
        515                 520                 525             


Tyr Val Lys Tyr Cys Thr Asn Glu Val Tyr Gln Gln Arg Thr Leu Gln 
    530                 535                 540                 


Lys Leu Leu Ala Thr Asn Pro Ser Phe Lys Glu Val Leu Ser Arg Ile 
545                 550                 555                 560 


Glu Ser His Glu Asp Cys Arg Asn Leu Pro Met Ile Ser Phe Leu Ile 
                565                 570                 575     


Leu Pro Met Gln Arg Val Thr Arg Leu Pro Leu Leu Met Asp Thr Ile 
            580                 585                 590         


Cys Gln Lys Thr Pro Lys Asp Ser Pro Lys Tyr Glu Val Cys Lys Arg 
        595                 600                 605             


Ala Leu Lys Glu Val Ser Lys Leu Val Arg Leu Cys Asn Glu Gly Ala 
    610                 615                 620                 


Arg Lys Met Glu Arg Thr Glu Met Met Tyr Thr Ile Asn Ser Gln Leu 
625                 630                 635                 640 


Glu Phe Lys Ile Lys Pro Phe Pro Leu Val Ser Ser Ser Arg Trp Leu 
                645                 650                 655     


Val Lys Arg Gly Glu Leu Thr Ala Tyr Val Glu Asp Thr Val Leu Phe 
            660                 665                 670         


Ser Arg Arg Thr Ser Lys Gln Gln Val Tyr Phe Phe Leu Phe Asn Asp 
        675                 680                 685             


Val Leu Ile Ile Thr Lys Lys Lys Ser Glu Glu Ser Tyr Asn Val Asn 
    690                 695                 700                 


Asp Tyr Ser Leu Arg Asp Gln Leu Leu Val Glu Ser Cys Asp Asn Glu 
705                 710                 715                 720 


Glu Leu Asn Ser Ser Pro Gly Lys Asn Ser Ser Thr Met Leu Tyr Ser 
                725                 730                 735     


Arg Gln Ser Ser Ala Ser His Leu Phe Thr Leu Thr Val Leu Ser Asn 
            740                 745                 750         


His Ala Asn Glu Lys Val Glu Met Leu Leu Gly Ala Glu Thr Gln Ser 
        755                 760                 765             


Glu Arg Ala Arg Trp Ile Thr Ala Leu Gly His Ser Ser Gly Lys Pro 
    770                 775                 780                 


Pro Ala Asp Arg Thr Cys Gly 
785                 790     


<210>  741
<211>  1731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF28__Homo_sapiens__NP_001073948

<400>  741

Met Glu Leu Ser Cys Ser Glu Ala Pro Leu Tyr Gly Gln Met Met Ile 
1               5                   10                  15      


Tyr Ala Lys Phe Asp Lys Asn Val Tyr Leu Pro Glu Asp Ala Glu Phe 
            20                  25                  30          


Tyr Phe Thr Tyr Asp Gly Ser His Gln Arg His Val Met Ile Ala Glu 
        35                  40                  45              


Arg Ile Glu Asp Asn Val Leu Gln Ser Ser Val Pro Gly His Gly Leu 
    50                  55                  60                  


Gln Glu Thr Val Thr Val Ser Val Cys Leu Cys Ser Glu Gly Tyr Ser 
65                  70                  75                  80  


Pro Val Thr Met Gly Ser Gly Ser Val Thr Tyr Val Asp Asn Met Ala 
                85                  90                  95      


Cys Arg Leu Ala Arg Leu Leu Val Thr Gln Ala Asn Arg Leu Thr Ala 
            100                 105                 110         


Cys Ser His Gln Thr Leu Leu Thr Pro Phe Ala Leu Thr Ala Gly Ala 
        115                 120                 125             


Leu Pro Ala Leu Asp Glu Glu Leu Val Leu Ala Leu Thr His Leu Glu 
    130                 135                 140                 


Leu Pro Leu Glu Trp Thr Val Leu Gly Ser Ser Ser Leu Glu Val Ser 
145                 150                 155                 160 


Ser His Arg Glu Ser Leu Leu His Leu Ala Met Arg Trp Gly Leu Ala 
                165                 170                 175     


Lys Leu Ser Gln Phe Phe Leu Cys Leu Pro Gly Gly Val Gln Ala Leu 
            180                 185                 190         


Ala Leu Pro Asn Glu Glu Gly Ala Thr Pro Leu Asp Leu Ala Leu Arg 
        195                 200                 205             


Glu Gly His Ser Lys Leu Val Glu Asp Val Thr Asn Phe Gln Gly Arg 
    210                 215                 220                 


Trp Ser Pro Ser Phe Ser Arg Val Gln Leu Ser Glu Glu Ala Ser Leu 
225                 230                 235                 240 


His Tyr Ile His Ser Ser Glu Thr Leu Thr Leu Thr Leu Asn His Thr 
                245                 250                 255     


Ala Glu His Leu Leu Glu Ala Asp Ile Lys Leu Phe Arg Lys Tyr Phe 
            260                 265                 270         


Trp Asp Arg Ala Phe Leu Val Lys Ala Phe Glu Pro Glu Ala Arg Pro 
        275                 280                 285             


Glu Glu Arg Thr Ala Met Pro Ser Ser Gly Ala Glu Thr Glu Glu Glu 
    290                 295                 300                 


Ile Lys Asn Ser Val Ser Ser Arg Ser Ala Ala Glu Lys Glu Asp Ile 
305                 310                 315                 320 


Lys Arg Val Lys Ser Leu Val Val Gln His Asn Glu His Glu Asp Gln 
                325                 330                 335     


His Ser Leu Asp Leu Asp Arg Ser Phe Asp Ile Leu Lys Lys Ser Lys 
            340                 345                 350         


Pro Pro Ser Thr Leu Leu Ala Ala Gly Arg Leu Ser Asp Met Leu Asn 
        355                 360                 365             


Gly Gly Asp Glu Val Tyr Ala Asn Cys Met Val Ile Asp Gln Val Gly 
    370                 375                 380                 


Asp Leu Asp Ile Ser Tyr Ile Asn Ile Glu Gly Ile Thr Ala Thr Thr 
385                 390                 395                 400 


Ser Pro Glu Ser Arg Gly Cys Thr Leu Trp Pro Gln Ser Ser Lys His 
                405                 410                 415     


Thr Leu Pro Thr Glu Thr Ser Pro Ser Val Tyr Pro Leu Ser Glu Asn 
            420                 425                 430         


Val Glu Gly Thr Ala His Thr Glu Ala Gln Gln Ser Phe Met Ser Pro 
        435                 440                 445             


Ser Ser Ser Cys Ala Ser Asn Leu Asn Leu Ser Phe Gly Trp His Gly 
    450                 455                 460                 


Phe Glu Lys Glu Gln Ser His Leu Lys Lys Arg Ser Ser Ser Leu Asp 
465                 470                 475                 480 


Ala Leu Asp Ala Asp Ser Glu Gly Glu Gly His Ser Glu Pro Ser His 
                485                 490                 495     


Ile Cys Tyr Thr Pro Gly Ser Gln Ser Ser Ser Arg Thr Gly Ile Pro 
            500                 505                 510         


Ser Gly Asp Glu Leu Asp Ser Phe Glu Thr Asn Thr Glu Pro Asp Phe 
        515                 520                 525             


Asn Ile Ser Arg Ala Glu Ser Leu Pro Leu Ser Ser Asn Leu Gln Ser 
    530                 535                 540                 


Lys Glu Ser Leu Leu Ser Gly Val Arg Ser Arg Ser Tyr Ser Cys Ser 
545                 550                 555                 560 


Ser Pro Lys Ile Ser Leu Gly Lys Thr Arg Leu Val Arg Glu Leu Thr 
                565                 570                 575     


Val Cys Ser Ser Ser Glu Glu Gln Arg Ala Tyr Ser Leu Ser Glu Pro 
            580                 585                 590         


Pro Arg Glu Asn Arg Ile Gln Glu Glu Glu Trp Asp Lys Tyr Ile Ile 
        595                 600                 605             


Pro Ala Lys Ser Glu Ser Glu Lys Tyr Lys Val Ser Arg Thr Phe Ser 
    610                 615                 620                 


Phe Leu Met Asn Arg Met Thr Ser Pro Arg Asn Lys Ser Lys Thr Lys 
625                 630                 635                 640 


Ser Lys Asp Ala Lys Asp Lys Glu Lys Leu Asn Arg His Gln Phe Ala 
                645                 650                 655     


Pro Gly Thr Phe Ser Gly Val Leu Gln Cys Leu Val Cys Asp Lys Thr 
            660                 665                 670         


Leu Leu Gly Lys Glu Ser Leu Gln Cys Ser Asn Cys Asn Ala Asn Val 
        675                 680                 685             


His Lys Gly Cys Lys Asp Ala Ala Pro Ala Cys Thr Lys Lys Phe Gln 
    690                 695                 700                 


Glu Lys Tyr Asn Lys Asn Lys Pro Gln Thr Ile Leu Gly Asn Ser Ser 
705                 710                 715                 720 


Phe Arg Asp Ile Pro Gln Pro Gly Leu Ser Leu His Pro Ser Ser Ser 
                725                 730                 735     


Val Pro Val Gly Leu Pro Thr Gly Arg Arg Glu Thr Val Gly Gln Val 
            740                 745                 750         


His Pro Leu Ser Arg Ser Val Pro Gly Thr Thr Leu Glu Ser Phe Arg 
        755                 760                 765             


Arg Ser Ala Thr Ser Leu Glu Ser Glu Ser Asp His Asn Ser Cys Arg 
    770                 775                 780                 


Ser Arg Ser His Ser Asp Glu Leu Leu Gln Ser Met Gly Ser Ser Pro 
785                 790                 795                 800 


Ser Thr Glu Ser Phe Ile Met Glu Asp Val Val Asp Ser Ser Leu Trp 
                805                 810                 815     


Ser Asp Leu Ser Ser Asp Ala Gln Glu Phe Glu Ala Glu Ser Trp Ser 
            820                 825                 830         


Leu Val Val Asp Pro Ser Phe Cys Asn Arg Gln Glu Lys Asp Val Ile 
        835                 840                 845             


Lys Arg Gln Asp Val Ile Phe Glu Leu Met Gln Thr Glu Met His His 
    850                 855                 860                 


Ile Gln Thr Leu Phe Ile Met Ser Glu Ile Phe Arg Lys Gly Met Lys 
865                 870                 875                 880 


Glu Glu Leu Gln Leu Asp His Ser Thr Val Asp Lys Ile Phe Pro Cys 
                885                 890                 895     


Leu Asp Glu Leu Leu Glu Ile His Arg His Phe Phe Tyr Ser Met Lys 
            900                 905                 910         


Glu Arg Arg Gln Glu Ser Cys Ala Gly Ser Asp Arg Asn Phe Val Ile 
        915                 920                 925             


Asp Arg Ile Gly Asp Ile Leu Val Gln Gln Phe Ser Glu Glu Asn Ala 
    930                 935                 940                 


Ser Lys Met Lys Lys Ile Tyr Gly Glu Phe Cys Cys His His Lys Glu 
945                 950                 955                 960 


Ala Val Asn Leu Phe Lys Glu Leu Gln Gln Asn Lys Lys Phe Gln Asn 
                965                 970                 975     


Phe Ile Lys Leu Arg Asn Ser Asn Leu Leu Ala Arg Arg Arg Gly Ile 
            980                 985                 990         


Pro Glu Cys Ile Leu Leu Val Thr  Gln Arg Ile Thr Lys  Tyr Pro Val 
        995                 1000                 1005             


Leu Val  Glu Arg Ile Leu Gln  Tyr Thr Lys Glu Arg  Thr Glu Glu 
    1010                 1015                 1020             


His Lys  Asp Leu Arg Lys Ala  Leu Cys Leu Ile Lys  Asp Met Ile 
    1025                 1030                 1035             


Ala Thr  Val Asp Leu Lys Val  Asn Glu Tyr Glu Lys  Asn Gln Lys 
    1040                 1045                 1050             


Trp Leu  Glu Ile Leu Asn Lys  Ile Glu Asn Lys Thr  Tyr Thr Lys 
    1055                 1060                 1065             


Leu Lys  Asn Gly His Val Phe  Arg Lys Gln Ala Leu  Met Ser Glu 
    1070                 1075                 1080             


Glu Arg  Thr Leu Leu Tyr Asp  Gly Leu Val Tyr Trp  Lys Thr Ala 
    1085                 1090                 1095             


Thr Gly  Arg Phe Lys Asp Ile  Leu Ala Leu Leu Leu  Thr Asp Val 
    1100                 1105                 1110             


Leu Leu  Phe Leu Gln Glu Lys  Asp Gln Lys Tyr Ile  Phe Ala Ala 
    1115                 1120                 1125             


Val Asp  Gln Lys Pro Ser Val  Ile Ser Leu Gln Lys  Leu Ile Ala 
    1130                 1135                 1140             


Arg Glu  Val Ala Asn Glu Glu  Arg Gly Met Phe Leu  Ile Ser Ala 
    1145                 1150                 1155             


Ser Ser  Ala Gly Pro Glu Met  Tyr Glu Ile His Thr  Asn Ser Lys 
    1160                 1165                 1170             


Glu Glu  Arg Asn Asn Trp Met  Arg Arg Ile Gln Gln  Ala Val Glu 
    1175                 1180                 1185             


Ser Cys  Pro Glu Glu Lys Gly  Gly Arg Thr Ser Glu  Ser Asp Glu 
    1190                 1195                 1200             


Asp Lys  Arg Lys Ala Glu Ala  Arg Val Ala Lys Ile  Gln Gln Cys 
    1205                 1210                 1215             


Gln Glu  Ile Leu Thr Asn Gln  Asp Gln Gln Ile Cys  Ala Tyr Leu 
    1220                 1225                 1230             


Glu Glu  Lys Leu His Ile Tyr  Ala Glu Leu Gly Glu  Leu Ser Gly 
    1235                 1240                 1245             


Phe Glu  Asp Val His Leu Glu  Pro His Leu Leu Ile  Lys Pro Asp 
    1250                 1255                 1260             


Pro Gly  Glu Pro Pro Gln Ala  Ala Ser Leu Leu Ala  Ala Ala Leu 
    1265                 1270                 1275             


Lys Glu  Ala Glu Ser Leu Gln  Val Ala Val Lys Ala  Ser Gln Met 
    1280                 1285                 1290             


Gly Ala  Val Ser Gln Ser Cys  Glu Asp Ser Cys Gly  Asp Ser Val 
    1295                 1300                 1305             


Leu Ala  Asp Thr Leu Ser Ser  His Asp Val Pro Gly  Ser Pro Thr 
    1310                 1315                 1320             


Ala Ser  Leu Val Thr Gly Gly  Arg Glu Gly Arg Gly  Cys Ser Asp 
    1325                 1330                 1335             


Val Asp  Pro Gly Ile Gln Gly  Val Val Thr Asp Leu  Ala Val Ser 
    1340                 1345                 1350             


Asp Ala  Gly Glu Lys Val Glu  Cys Arg Asn Phe Pro  Gly Ser Ser 
    1355                 1360                 1365             


Gln Ser  Glu Ile Ile Gln Ala  Ile Gln Asn Leu Thr  Arg Leu Leu 
    1370                 1375                 1380             


Tyr Ser  Leu Gln Ala Ala Leu  Thr Ile Gln Asp Ser  His Ile Glu 
    1385                 1390                 1395             


Ile His  Arg Leu Val Leu Gln  Gln Gln Glu Gly Leu  Ser Leu Gly 
    1400                 1405                 1410             


His Ser  Ile Leu Arg Gly Gly  Pro Leu Gln Asp Gln  Lys Ser Arg 
    1415                 1420                 1425             


Asp Ala  Asp Arg Gln His Glu  Glu Leu Ala Asn Val  His Gln Leu 
    1430                 1435                 1440             


Gln His  Gln Leu Gln Gln Glu  Gln Arg Arg Trp Leu  Arg Arg Cys 
    1445                 1450                 1455             


Glu Gln  Gln Gln Arg Ala Gln  Ala Thr Arg Glu Ser  Trp Leu Gln 
    1460                 1465                 1470             


Glu Arg  Glu Arg Glu Cys Gln  Ser Gln Glu Glu Leu  Leu Leu Arg 
    1475                 1480                 1485             


Ser Arg  Gly Glu Leu Asp Leu  Gln Leu Gln Glu Tyr  Gln His Ser 
    1490                 1495                 1500             


Leu Glu  Arg Leu Arg Glu Gly  Gln Arg Leu Val Glu  Arg Glu Gln 
    1505                 1510                 1515             


Ala Arg  Met Arg Ala Gln Gln  Ser Leu Leu Gly His  Trp Lys His 
    1520                 1525                 1530             


Gly Arg  Gln Arg Ser Leu Pro  Ala Val Leu Leu Pro  Gly Gly Pro 
    1535                 1540                 1545             


Glu Val  Met Glu Leu Asn Arg  Ser Glu Ser Leu Cys  His Glu Asn 
    1550                 1555                 1560             


Ser Phe  Phe Ile Asn Glu Ala  Leu Val Gln Met Ser  Phe Asn Thr 
    1565                 1570                 1575             


Phe Asn  Lys Leu Asn Pro Ser  Val Ile His Gln Asp  Ala Thr Tyr 
    1580                 1585                 1590             


Pro Thr  Thr Gln Ser His Ser  Asp Leu Val Arg Thr  Ser Glu His 
    1595                 1600                 1605             


Gln Val  Asp Leu Lys Val Asp  Pro Ser Gln Pro Ser  Asn Val Ser 
    1610                 1615                 1620             


His Lys  Leu Trp Thr Ala Ala  Gly Ser Gly His Gln  Ile Leu Pro 
    1625                 1630                 1635             


Phe His  Glu Ser Ser Lys Asp  Ser Cys Lys Asn Gly  Ser Ser Met 
    1640                 1645                 1650             


Thr Lys  Cys Ser Cys Thr Leu  Thr Ser Pro Pro Gly  Leu Trp Thr 
    1655                 1660                 1665             


Gly Thr  Thr Ser Thr Leu Lys  Asp Leu Asp Thr Ser  His Thr Glu 
    1670                 1675                 1680             


Ser Pro  Thr Pro His Asp Ser  Asn Ser His Arg Pro  Gln Leu Gln 
    1685                 1690                 1695             


Ala Phe  Ile Thr Glu Ala Lys  Leu Asn Leu Pro Thr  Arg Thr Met 
    1700                 1705                 1710             


Thr Arg  Gln Asp Gly Glu Thr  Gly Asp Gly Ala Lys  Glu Asn Ile 
    1715                 1720                 1725             


Val Tyr  Leu 
    1730     


<210>  742
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF2__Homo_sapiens__NP_001155855

<400>  742

Met Ser Arg Ile Glu Ser Leu Thr Arg Ala Arg Ile Asp Arg Ser Arg 
1               5                   10                  15      


Glu Leu Ala Ser Lys Thr Arg Glu Lys Glu Lys Met Lys Glu Ala Lys 
            20                  25                  30          


Asp Ala Arg Tyr Thr Asn Gly His Leu Phe Thr Thr Ile Ser Val Ser 
        35                  40                  45              


Gly Met Thr Met Cys Tyr Ala Cys Asn Lys Ser Ile Thr Ala Lys Glu 
    50                  55                  60                  


Ala Leu Ile Cys Pro Thr Cys Asn Val Thr Ile His Asn Arg Cys Lys 
65                  70                  75                  80  


Asp Thr Leu Ala Asn Cys Thr Lys Val Lys Gln Lys Gln Gln Lys Ala 
                85                  90                  95      


Ala Leu Leu Lys Asn Asn Thr Ala Leu Gln Ser Val Ser Leu Arg Ser 
            100                 105                 110         


Lys Thr Thr Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp 
        115                 120                 125             


Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu 
    130                 135                 140                 


Ser Leu Ala Lys Ser Val Ser Thr Thr Asn Ile Ala Gly His Phe Asn 
145                 150                 155                 160 


Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Thr Asp 
                165                 170                 175     


Ser Leu Asn Met Arg Asn Arg Thr Leu Ser Val Glu Ser Leu Ile Asp 
            180                 185                 190         


Glu Ala Glu Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp 
        195                 200                 205             


Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser 
    210                 215                 220                 


Phe Leu Gln Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile 
225                 230                 235                 240 


Tyr Glu Leu Ile Gln Thr Glu Leu His His Val Arg Thr Leu Lys Ile 
                245                 250                 255     


Met Thr Arg Leu Phe Arg Thr Gly Met Leu Glu Glu Leu His Leu Glu 
            260                 265                 270         


Pro Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp 
        275                 280                 285             


Ile His Thr Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala 
    290                 295                 300                 


Leu Cys Pro Gly Ser Thr Arg Asn Phe Val Ile His Arg Leu Gly Asp 
305                 310                 315                 320 


Leu Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys 
                325                 330                 335     


Thr Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr 
            340                 345                 350         


Lys Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys 
        355                 360                 365             


Val Thr Arg Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile 
    370                 375                 380                 


Leu Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro Leu Leu Ile Ser Arg 
385                 390                 395                 400 


Ile Leu Gln His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Thr 
                405                 410                 415     


Thr Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly 
            420                 425                 430         


Ile Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg 
        435                 440                 445             


Met Asp Pro Arg Ala Gln Thr Pro Val Pro Gly Lys Gly Pro Phe Gly 
    450                 455                 460                 


Arg Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu 
465                 470                 475                 480 


Trp Lys Thr Ala Thr Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met 
                485                 490                 495     


Thr Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe 
            500                 505                 510         


Pro Thr Leu Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val 
        515                 520                 525             


Arg Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala 
    530                 535                 540                 


Pro Pro Glu Met Tyr Glu Val His Thr Ala Ser Arg Asp Asp Arg Ser 
545                 550                 555                 560 


Thr Trp Ile Arg Val Ile Gln Gln Ser Val Arg Thr Cys Pro Ser Arg 
                565                 570                 575     


Glu Asp Phe Pro Leu Ile Glu Thr Glu Asp Glu Ala Tyr Leu Arg Arg 
            580                 585                 590         


Ile Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu 
        595                 600                 605             


Arg Glu Lys Val Gly Leu Phe Ala Glu Met Thr His Phe Gln Ala Glu 
    610                 615                 620                 


Glu Asp Gly Gly Ser Gly Met Ala Leu Pro Thr Leu Pro Arg Gly Leu 
625                 630                 635                 640 


Phe Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln 
                645                 650                 655     


Asp Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro 
            660                 665                 670         


Gly Val Glu Leu Leu Leu Thr Pro Arg Glu Pro Ala Leu Pro Leu Glu 
        675                 680                 685             


Pro Asp Ser Gly Gly Asn Thr Ser Pro Gly Val Thr Ala Asn Gly Glu 
    690                 695                 700                 


Ala Arg Thr Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp 
705                 710                 715                 720 


Ser Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu 
                725                 730                 735     


Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu 
            740                 745                 750         


Gln Ala Ala Val Ala Gln Gln Asp Thr Leu Met Glu Ala Arg Phe Pro 
        755                 760                 765             


Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp 
    770                 775                 780                 


Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln 
785                 790                 795                 800 


Ala Thr Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu 
                805                 810                 815     


Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Thr Glu Ala 
            820                 825                 830         


Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu 
        835                 840                 845             


Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly 
    850                 855                 860                 


Gln Thr Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val 
865                 870                 875                 880 


Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser 
                885                 890                 895     


Phe Asn Pro Pro Gln Pro Ser Arg Gly Thr Asp Arg Leu Asp Leu Pro 
            900                 905                 910         


Val Thr Thr Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln 
        915                 920                 925             


Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp 
    930                 935                 940                 


Thr Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser 
945                 950                 955                 960 


Pro Arg Asp Phe Thr Arg Met Gln Asp Ile Pro Glu Glu Thr Glu Ser 
                965                 970                 975     


Arg Asp Gly Glu Ala Val Ala Ser Glu Ser 
            980                 985     


<210>  743
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF38__Homo_sapiens__NP_001229658

<400>  743

Met Glu Pro Lys Glu Ala Thr Gly Lys Glu Asn Met Val Thr Lys Lys 
1               5                   10                  15      


Lys Asn Leu Ala Phe Leu Arg Ser Arg Leu Tyr Met Leu Glu Arg Arg 
            20                  25                  30          


Lys Thr Asp Thr Val Val Glu Ser Ser Val Ser Gly Asp His Ser Gly 
        35                  40                  45              


Thr Leu Arg Arg Ser Gln Ser Asp Arg Thr Glu Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Gln Glu Lys Met Thr Pro Gln Gly Glu Cys Ser Val Ala Glu Thr Leu 
65                  70                  75                  80  


Thr Pro Glu Glu Glu His His Met Lys Arg Met Met Ala Lys Arg Glu 
                85                  90                  95      


Lys Ile Ile Lys Glu Leu Ile Gln Thr Glu Lys Asp Tyr Leu Asn Asp 
            100                 105                 110         


Leu Glu Leu Cys Val Arg Glu Val Val Gln Pro Leu Arg Asn Lys Lys 
        115                 120                 125             


Thr Asp Arg Leu Asp Val Asp Ser Leu Phe Ser Asn Ile Glu Ser Val 
    130                 135                 140                 


His Gln Ile Ser Ala Lys Leu Leu Ser Leu Leu Glu Glu Ala Thr Thr 
145                 150                 155                 160 


Asp Val Glu Pro Ala Met Gln Val Ile Gly Glu Val Phe Leu Gln Ile 
                165                 170                 175     


Lys Gly Pro Leu Glu Asp Ile Tyr Lys Ile Tyr Cys Tyr His His Asp 
            180                 185                 190         


Glu Ala His Ser Ile Leu Glu Ser Tyr Glu Lys Glu Glu Glu Leu Lys 
        195                 200                 205             


Glu His Leu Ser His Cys Ile Gln Ser Leu Lys Lys Ile Tyr Met Gln 
    210                 215                 220                 


Glu Gly Lys Pro Asn Leu Leu Asp Met Gly Ser Leu Met Ile Lys Pro 
225                 230                 235                 240 


Ile Gln Arg Val Met Lys Tyr Pro Leu Leu Leu Cys Glu Leu Arg Asn 
                245                 250                 255     


Ser Thr Pro Pro Ser His Pro Asp Tyr Arg Ala Leu Asp Asp Ala Phe 
            260                 265                 270         


Ala Ala Val Lys Asp Ile Asn Val Asn Ile Asn Glu Leu Lys Arg Arg 
        275                 280                 285             


Lys Asp Leu Val Leu Lys Tyr Lys Lys Asn Asp Glu Asp Glu Ser Leu 
    290                 295                 300                 


Lys Asp Lys Leu Ser Lys Leu Asn Ile His Ser Ile Ser Lys Lys Ser 
305                 310                 315                 320 


Lys Arg Val Thr Asn His Leu Lys Ile Leu Thr Arg Gly Glu Ser Gln 
                325                 330                 335     


Val Lys Asp Asn Thr Phe Asn Arg Glu Glu Lys Leu Phe Arg Ala Leu 
            340                 345                 350         


Glu Lys Thr Val Arg Leu Cys Val Lys Asn Ile Ser Leu Cys Leu Gln 
        355                 360                 365             


His Ile Gln Asp Ala Met Pro Leu Ala Leu Gln Ser Val Met Asp Leu 
    370                 375                 380                 


Gln Glu Ile Ser Tyr Asn Lys Asp Asp Glu Met Asp Tyr Ser Glu Thr 
385                 390                 395                 400 


Leu Ser Asn Ala Leu Asn Ser Cys His Asp Phe Ala Ser His Leu Gln 
                405                 410                 415     


Arg Leu Ile Leu Thr Pro Leu Ser Ala Leu Leu Ser Leu Phe Pro Gly 
            420                 425                 430         


Pro His Lys Leu Ile Gln Lys Arg Tyr Asp Lys Leu Leu Asp Cys Asn 
        435                 440                 445             


Ser Tyr Leu Gln Arg Ser Thr Gly Glu Glu Ser Asp Leu Ala Lys Lys 
    450                 455                 460                 


Glu Tyr Glu Ala Leu Asn Ala Gln Leu Val Glu Glu Leu Gln Ala Phe 
465                 470                 475                 480 


Asn Gln Ala Ala Arg Lys Ile Leu Leu Asn Cys Leu Cys Ser Phe Ile 
                485                 490                 495     


Thr Leu Leu Arg Asp Leu Met Leu Val Ala Gln Gln Ala Tyr Ser Thr 
            500                 505                 510         


Leu Val Pro Met Pro Leu Leu Val Ser Ser Ile Ser Glu Ile Gln Asn 
        515                 520                 525             


Gln Val Leu Glu Glu Ile Gln Asn Leu Asn Cys Val Lys Glu Asn Ser 
    530                 535                 540                 


Ala Thr Phe Ile Glu Arg Lys Leu Ser Phe Glu Lys Lys Lys Pro Val 
545                 550                 555                 560 


Gln Ile Leu Pro Glu Met Pro His Gln Thr Asp Ile His Arg Ser Lys 
                565                 570                 575     


Leu Leu Ser Thr Tyr Ser Ala Glu Glu Leu Tyr Gln Ala Lys Arg Lys 
            580                 585                 590         


Cys Asn Ala Thr Gln Glu Tyr Asp Ile Asn Leu Leu Glu Gly Asp Leu 
        595                 600                 605             


Val Ala Val Ile Glu Gln Lys Asp Pro Leu Gly Ser Thr Ser Arg Trp 
    610                 615                 620                 


Leu Val Asp Thr Gly Asn Val Lys Gly Tyr Val Tyr Ser Ser Phe Leu 
625                 630                 635                 640 


Lys Pro Tyr Asn Pro Ala Lys Met Gln Lys Val Asp Ala Glu Asn Arg 
                645                 650                 655     


Phe Cys Asp Asp Asp Phe Glu Asn Ile Ser Leu Phe Val Ser Ser Arg 
            660                 665                 670         


Pro Ala Ser Asp Ser Val Thr Gly Thr Ser Glu Ser Ser Ile Gly Asp 
        675                 680                 685             


Ser Ser Ser Ser Leu Ser Gly Thr Cys Gly Lys Phe Glu Thr Asn Gly 
    690                 695                 700                 


Thr Asp Val Asp Ser Phe Gln Glu Val Asp Glu Gln Ile Phe Tyr Ala 
705                 710                 715                 720 


Val His Ala Phe Gln Ala Arg Ser Asp His Glu Leu Ser Leu Gln Glu 
                725                 730                 735     


Tyr Gln Arg Val His Ile Leu Arg Phe Cys Asp Leu Ser Gly Asn Lys 
            740                 745                 750         


Glu Trp Trp Leu Ala Glu Ala Gln Gly Gln Lys Gly Tyr Val Pro Ala 
        755                 760                 765             


Asn Tyr Leu Gly Lys Met Thr Tyr Ala 
    770                 775         


<210>  744
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF3__Homo_sapiens__NP_001122087

<400>  744

Met Asp Ser Ser Thr Ala Met Asn Gln Cys Ser Cys Arg Gly Met Glu 
1               5                   10                  15      


Glu Asn Lys Glu Arg Pro Lys Arg Gln Arg Gln Asn Asn Phe Pro Met 
            20                  25                  30          


Phe Pro Ser Pro Lys Ala Trp Asn Phe Arg Gly Arg Lys Arg Lys Gln 
        35                  40                  45              


Ser Thr Gln Asp Glu Asp Ala Val Ser Leu Cys Ser Leu Asp Ile Ser 
    50                  55                  60                  


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Thr Ser Leu 
65                  70                  75                  80  


Ala Asn Leu Ile Pro Pro Val Lys Ala Thr Pro Leu Lys Arg Phe Ser 
                85                  90                  95      


Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
            100                 105                 110         


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Thr 
        115                 120                 125             


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Thr Phe Asp Val Cys Val 
    130                 135                 140                 


Asn Gln Met Leu Thr Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
145                 150                 155                 160 


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
                165                 170                 175     


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Thr Glu 
            180                 185                 190         


Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu Asp Ser Leu Ile Pro Leu 
        195                 200                 205             


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
    210                 215                 220                 


Ser Thr Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
225                 230                 235                 240 


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
                245                 250                 255     


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
            260                 265                 270         


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
        275                 280                 285             


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
    290                 295                 300                 


Ile Leu Arg His Thr Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
305                 310                 315                 320 


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Thr Lys 
                325                 330                 335     


Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
            340                 345                 350         


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
        355                 360                 365             


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
    370                 375                 380                 


Leu Phe Gln Glu Val Leu Val Ile Thr Arg Ala Val Thr His Asn Glu 
385                 390                 395                 400 


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
                405                 410                 415     


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
            420                 425                 430         


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
        435                 440                 445             


Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr His Ser Leu Gln Ala Asn 
    450                 455                 460                 


Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
465                 470                 475                 480 


Glu Thr Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
                485                 490                 495     


Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser Arg Glu Leu Gln Gly Glu 
            500                 505                 510         


Thr Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
        515                 520                 525             


Met Asp Thr Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Thr 
    530                 535                 540                 


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
545                 550                 555             


<210>  745
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF4__Homo_sapiens__NP_056135

<400>  745

Met Pro Trp Glu Glu Pro Ala Gly Glu Lys Pro Ser Cys Ser His Ser 
1               5                   10                  15      


Gln Lys Ala Phe His Met Glu Pro Ala Gln Lys Pro Cys Phe Thr Thr 
            20                  25                  30          


Asp Met Val Thr Trp Ala Leu Leu Cys Ile Ser Ala Glu Thr Val Arg 
        35                  40                  45              


Gly Glu Ala Pro Ser Gln Pro Arg Gly Ile Pro His Arg Ser Pro Val 
    50                  55                  60                  


Ser Val Asp Asp Leu Trp Leu Glu Lys Thr Gln Arg Lys Lys Leu Gln 
65                  70                  75                  80  


Lys Gln Ala His Val Glu Arg Arg Leu His Ile Gly Ala Val His Lys 
                85                  90                  95      


Asp Gly Val Lys Cys Trp Arg Lys Thr Ile Ile Thr Ser Pro Glu Ser 
            100                 105                 110         


Leu Asn Leu Pro Arg Arg Ser His Pro Leu Ser Gln Ser Ala Pro Thr 
        115                 120                 125             


Gly Leu Asn His Met Gly Trp Pro Glu His Thr Pro Gly Thr Ala Met 
    130                 135                 140                 


Pro Asp Gly Ala Leu Asp Thr Ala Val Cys Ala Asp Glu Val Gly Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Tyr Asp Asp Leu His Ser Ser Ser His His Tyr Ser 
                165                 170                 175     


His Pro Gly Gly Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser 
            180                 185                 190         


Asp Gly Ser Val Val Cys Ala Glu Ala Leu Trp Asp His Val Thr Met 
        195                 200                 205             


Asp Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Glu Val Met 
    210                 215                 220                 


Asp Ala Thr Asn Arg Glu Trp Trp Trp Gly Arg Val Ala Asp Gly Glu 
225                 230                 235                 240 


Gly Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Asp Glu 
                245                 250                 255     


Pro Ala Asp Asp Asp Ala Pro Leu Ala Gly Asn Ser Gly Ala Glu Asp 
            260                 265                 270         


Gly Gly Ala Glu Ala Gln Ser Ser Lys Asp Gln Met Arg Thr Asn Val 
        275                 280                 285             


Ile Asn Glu Ile Leu Ser Thr Glu Arg Asp Tyr Ile Lys His Leu Arg 
    290                 295                 300                 


Asp Ile Cys Glu Gly Tyr Val Arg Gln Cys Arg Lys Arg Ala Asp Met 
305                 310                 315                 320 


Phe Ser Glu Glu Gln Leu Arg Thr Ile Phe Gly Asn Ile Glu Asp Ile 
                325                 330                 335     


Tyr Arg Cys Gln Lys Ala Phe Val Lys Ala Leu Glu Gln Arg Phe Asn 
            340                 345                 350         


Arg Glu Arg Pro His Leu Ser Glu Leu Gly Ala Cys Phe Leu Glu His 
        355                 360                 365             


Gln Ala Asp Phe Gln Ile Tyr Ser Glu Tyr Cys Asn Asn His Pro Asn 
    370                 375                 380                 


Ala Cys Val Glu Leu Ser Arg Leu Thr Lys Leu Ser Lys Tyr Val Tyr 
385                 390                 395                 400 


Phe Phe Glu Ala Cys Arg Leu Leu Gln Lys Met Ile Asp Ile Ser Leu 
                405                 410                 415     


Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile Cys Lys Tyr Pro Leu 
            420                 425                 430         


Gln Leu Ala Glu Leu Leu Lys Tyr Thr His Pro Gln His Arg Asp Phe 
        435                 440                 445             


Lys Asp Val Glu Ala Ala Leu His Ala Met Lys Asn Val Ala Gln Leu 
    450                 455                 460                 


Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn Ile Asp Lys Ile Ala Gln 
465                 470                 475                 480 


Trp Gln Ser Ser Ile Glu Asp Trp Glu Gly Glu Asp Leu Leu Val Arg 
                485                 490                 495     


Ser Ser Glu Leu Ile Tyr Ser Gly Glu Leu Thr Arg Val Thr Gln Pro 
            500                 505                 510         


Gln Ala Lys Ser Gln Gln Arg Met Phe Phe Leu Phe Asp His Gln Leu 
        515                 520                 525             


Ile Tyr Cys Lys Lys Asp Leu Leu Arg Arg Asp Val Leu Tyr Tyr Lys 
    530                 535                 540                 


Gly Arg Leu Asp Met Asp Gly Leu Glu Val Val Asp Leu Glu Asp Gly 
545                 550                 555                 560 


Lys Asp Arg Asp Leu His Val Ser Ile Lys Asn Ala Phe Arg Leu His 
                565                 570                 575     


Arg Gly Ala Thr Gly Asp Ser His Leu Leu Cys Thr Arg Lys Pro Glu 
            580                 585                 590         


Gln Lys Gln Arg Trp Leu Lys Ala Phe Ala Arg Glu Arg Glu Gln Val 
        595                 600                 605             


Gln Leu Asp Gln Glu Thr Gly Phe Ser Ile Thr Glu Leu Gln Arg Lys 
    610                 615                 620                 


Gln Ala Met Leu Asn Ala Ser Lys Gln Gln Val Thr Gly Lys Pro Lys 
625                 630                 635                 640 


Ala Val Gly Arg Pro Cys Tyr Leu Thr Arg Gln Lys His Pro Ala Leu 
                645                 650                 655     


Pro Ser Asn Arg Pro Gln Gln Gln Val Leu Val Leu Ala Glu Pro Arg 
            660                 665                 670         


Arg Lys Pro Ser Thr Phe Trp His Ser Ile Ser Arg Leu Ala Pro Phe 
        675                 680                 685             


Arg Lys 
    690 


<210>  746
<211>  1597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF5__Homo_sapiens__NP_005426

<400>  746

Met Glu Ala Glu Glu Ala Gln Arg Gly Ala Ser Pro Pro Ile Ser Ala 
1               5                   10                  15      


Ile Glu Glu Phe Ser Ile Ile Pro Glu Ala Pro Met Arg Ser Ser Gln 
            20                  25                  30          


Val Ser Ala Leu Gly Leu Glu Ala Gln Glu Asp Glu Asp Pro Ser Tyr 
        35                  40                  45              


Lys Trp Arg Glu Glu His Arg Leu Ser Ala Thr Gln Gln Ser Glu Leu 
    50                  55                  60                  


Arg Asp Val Cys Asp Tyr Ala Ile Glu Thr Met Pro Ser Phe Pro Lys 
65                  70                  75                  80  


Glu Gly Ser Ala Asp Val Glu Pro Asn Gln Glu Ser Leu Val Ala Glu 
                85                  90                  95      


Ala Cys Asp Thr Pro Glu His Trp Glu Ala Val Pro Gln Ser Leu Ala 
            100                 105                 110         


Gly Arg Gln Ala Arg Thr Leu Ala Pro Pro Glu Leu Trp Ala Cys Pro 
        115                 120                 125             


Ile Gln Ser Glu His Leu Asp Met Ala Pro Phe Ser Ser Asp Leu Gly 
    130                 135                 140                 


Ser Glu Glu Glu Glu Val Glu Phe Trp Pro Gly Leu Thr Ser Leu Thr 
145                 150                 155                 160 


Leu Gly Ser Gly Gln Ala Glu Glu Glu Glu Glu Thr Ser Ser Asp Asn 
                165                 170                 175     


Ser Gly Gln Thr Arg Tyr Tyr Ser Pro Cys Glu Glu His Pro Ala Glu 
            180                 185                 190         


Thr Asn Gln Asn Glu Gly Ser Glu Ser Gly Thr Ile Arg Gln Gly Glu 
        195                 200                 205             


Glu Leu Pro Pro Glu Glu Leu Gln Glu Ser Gln Gly Leu Leu His Pro 
    210                 215                 220                 


Gln Glu Val Gln Val Leu Glu Glu Gln Gly Gln Gln Glu Ala Gly Phe 
225                 230                 235                 240 


Arg Gly Glu Gly Thr Leu Arg Glu Asp Val Cys Ala Asp Gly Leu Leu 
                245                 250                 255     


Gly Glu Glu Gln Met Ile Glu Gln Val Asn Asp Glu Lys Gly Glu Gln 
            260                 265                 270         


Lys Gln Lys Gln Glu Gln Val Gln Asp Val Met Leu Gly Arg Gln Gly 
        275                 280                 285             


Glu Arg Met Gly Leu Thr Gly Glu Pro Glu Gly Leu Asn Asp Gly Glu 
    290                 295                 300                 


Trp Glu Gln Glu Asp Met Glu Arg Lys Ala Gln Gly Gln Gly Gly Pro 
305                 310                 315                 320 


Glu Gln Gly Glu Glu Arg Lys Arg Glu Leu Gln Val Pro Glu Glu Asn 
                325                 330                 335     


Arg Ala Asp Ser Gln Asp Glu Lys Ser Gln Thr Phe Leu Gly Lys Ser 
            340                 345                 350         


Glu Glu Val Thr Gly Lys Gln Glu Asp His Gly Ile Lys Glu Lys Gly 
        355                 360                 365             


Val Pro Val Ser Gly Gln Glu Ala Lys Glu Pro Glu Ser Trp Asp Gly 
    370                 375                 380                 


Gly Arg Leu Gly Ala Val Gly Arg Ala Arg Ser Arg Glu Glu Glu Asn 
385                 390                 395                 400 


Glu His His Gly Pro Ser Met Pro Ala Leu Ile Ala Pro Glu Asp Ser 
                405                 410                 415     


Pro His Cys Asp Leu Phe Pro Gly Ala Ser Tyr Leu Met Thr Gln Ile 
            420                 425                 430         


Pro Gly Thr Gln Thr Glu Ser Arg Ala Glu Glu Leu Ser Pro Ala Ala 
        435                 440                 445             


Leu Ser Pro Ser Leu Glu Pro Ile Arg Cys Ser His Gln Pro Ile Ser 
    450                 455                 460                 


Leu Leu Gly Ser Phe Leu Thr Glu Glu Ser Pro Asp Lys Glu Ile Asp 
465                 470                 475                 480 


Gln Asn Ser Gln Gln Glu Glu Ser Arg Leu Arg Lys Gly Thr Val Ser 
                485                 490                 495     


Ser Gln Gly Thr Glu Val Val Phe Ala Ser Ala Ser Val Thr Pro Pro 
            500                 505                 510         


Arg Thr Pro Asp Ser Ala Pro Pro Ser Pro Ala Glu Ala Tyr Pro Ile 
        515                 520                 525             


Thr Pro Ala Ser Val Ser Ala Arg Pro Pro Val Ala Phe Pro Arg Arg 
    530                 535                 540                 


Glu Thr Ser Cys Ala Ala Arg Ala Pro Glu Thr Ala Ser Ala Pro Leu 
545                 550                 555                 560 


Ser Met Asp Asp Pro Ser Pro Cys Gly Thr Ser Glu Met Cys Pro Ala 
                565                 570                 575     


Ala Leu Tyr Gly Phe Pro Ser Thr Gly Thr Ser Pro Pro Arg Pro Pro 
            580                 585                 590         


Ala Asn Ser Thr Gly Thr Val Gln His Leu Arg Ser Asp Ser Phe Pro 
        595                 600                 605             


Gly Ser His Arg Thr Glu Gln Thr Pro Asp Leu Val Gly Met Leu Leu 
    610                 615                 620                 


Ser Tyr Ser His Ser Glu Leu Pro Gln Arg Pro Pro Lys Pro Ala Ile 
625                 630                 635                 640 


Tyr Ser Ser Val Thr Pro Arg Arg Asp Arg Arg Ser Gly Arg Asp Tyr 
                645                 650                 655     


Ser Thr Val Ser Ala Ser Pro Thr Ala Leu Ser Thr Leu Lys Gln Asp 
            660                 665                 670         


Ser Gln Glu Ser Ile Ser Asn Leu Glu Arg Pro Ser Ser Pro Pro Ser 
        675                 680                 685             


Ile Gln Pro Trp Val Ser Pro His Asn Pro Ala Phe Ala Thr Glu Ser 
    690                 695                 700                 


Pro Ala Tyr Gly Ser Ser Pro Ser Phe Val Ser Met Glu Asp Val Arg 
705                 710                 715                 720 


Ile His Glu Pro Leu Pro Pro Pro Pro Pro Gln Arg Arg Asp Thr His 
                725                 730                 735     


Pro Ser Val Val Glu Thr Asp Gly His Ala Arg Val Val Val Pro Thr 
            740                 745                 750         


Leu Lys Gln His Ser His Pro Pro Pro Leu Ala Leu Gly Ser Gly Leu 
        755                 760                 765             


His Ala Pro His Lys Gly Pro Leu Pro Gln Ala Ser Asp Pro Ala Val 
    770                 775                 780                 


Ala Arg Gln His Arg Pro Leu Pro Ser Thr Pro Asp Ser Ser His His 
785                 790                 795                 800 


Ala Gln Ala Thr Pro Arg Trp Arg Tyr Asn Lys Pro Leu Pro Pro Thr 
                805                 810                 815     


Pro Asp Leu Pro Gln Pro His Leu Pro Pro Ile Ser Ala Pro Gly Ser 
            820                 825                 830         


Ser Arg Ile Tyr Arg Pro Leu Pro Pro Leu Pro Ile Ile Asp Pro Pro 
        835                 840                 845             


Thr Glu Pro Pro Pro Leu Pro Pro Lys Ser Arg Gly Arg Ser Arg Ser 
    850                 855                 860                 


Thr Arg Gly Gly His Met Asn Ser Gly Gly His Ala Lys Thr Arg Pro 
865                 870                 875                 880 


Ala Cys Gln Asp Trp Thr Val Pro Leu Pro Ala Ser Ala Gly Arg Thr 
                885                 890                 895     


Ser Trp Pro Pro Ala Thr Ala Arg Ser Thr Glu Ser Phe Thr Ser Thr 
            900                 905                 910         


Ser Arg Ser Lys Ser Glu Val Ser Pro Gly Met Ala Phe Ser Asn Met 
        915                 920                 925             


Thr Asn Phe Leu Cys Pro Ser Ser Pro Thr Thr Pro Trp Thr Pro Glu 
    930                 935                 940                 


Leu Gln Gly Pro Thr Ser Lys Asp Glu Ala Gly Val Ser Glu His Pro 
945                 950                 955                 960 


Glu Ala Pro Ala Arg Glu Pro Leu Arg Arg Thr Thr Pro Gln Gln Gly 
                965                 970                 975     


Ala Ser Gly Pro Gly Arg Ser Pro Val Gly Gln Ala Arg Gln Pro Glu 
            980                 985                 990         


Lys Pro Ser His Leu His Leu Glu  Lys Ala Ser Ser Trp  Pro His Arg 
        995                 1000                 1005             


Arg Asp  Ser Gly Arg Pro Pro  Gly Asp Ser Ser Gly  Gln Ala Val 
    1010                 1015                 1020             


Ala Pro  Ser Glu Gly Ala Asn  Lys His Lys Gly Trp  Ser Arg Gln 
    1025                 1030                 1035             


Gly Leu  Arg Arg Pro Ser Ile  Leu Pro Glu Gly Ser  Ser Asp Ser 
    1040                 1045                 1050             


Arg Gly  Pro Ala Val Glu Lys  His Pro Gly Pro Ser  Asp Thr Val 
    1055                 1060                 1065             


Val Phe  Arg Glu Lys Lys Pro  Lys Glu Val Met Gly  Gly Phe Ser 
    1070                 1075                 1080             


Arg Arg  Cys Ser Lys Leu Ile  Asn Ser Ser Gln Leu  Leu Tyr Gln 
    1085                 1090                 1095             


Glu Tyr  Ser Asp Val Val Leu  Asn Lys Glu Ile Gln  Ser Gln Gln 
    1100                 1105                 1110             


Arg Leu  Glu Ser Leu Ser Glu  Thr Pro Gly Pro Ser  Ser Pro Arg 
    1115                 1120                 1125             


Gln Pro  Arg Lys Ala Leu Val  Ser Ser Glu Ser Tyr  Leu Gln Arg 
    1130                 1135                 1140             


Leu Ser  Met Ala Ser Ser Gly  Ser Leu Trp Gln Glu  Ile Pro Val 
    1145                 1150                 1155             


Val Arg  Asn Ser Thr Val Leu  Leu Ser Met Thr His  Glu Asp Gln 
    1160                 1165                 1170             


Lys Leu  Gln Glu Val Lys Phe  Glu Leu Ile Val Ser  Glu Ala Ser 
    1175                 1180                 1185             


Tyr Leu  Arg Ser Leu Asn Ile  Ala Val Asp His Phe  Gln Leu Ser 
    1190                 1195                 1200             


Thr Ser  Leu Arg Ala Thr Leu  Ser Asn Gln Glu His  Gln Trp Leu 
    1205                 1210                 1215             


Phe Ser  Arg Leu Gln Asp Val  Arg Asp Val Ser Ala  Thr Phe Leu 
    1220                 1225                 1230             


Ser Asp  Leu Glu Glu Asn Phe  Glu Asn Asn Ile Phe  Ser Phe Gln 
    1235                 1240                 1245             


Val Cys  Asp Val Val Leu Asn  His Ala Pro Asp Phe  Arg Arg Val 
    1250                 1255                 1260             


Tyr Leu  Pro Tyr Val Thr Asn  Gln Thr Tyr Gln Glu  Arg Thr Phe 
    1265                 1270                 1275             


Gln Ser  Leu Met Asn Ser Asn  Ser Asn Phe Arg Glu  Val Leu Glu 
    1280                 1285                 1290             


Lys Leu  Glu Ser Asp Pro Val  Cys Gln Arg Leu Ser  Leu Lys Ser 
    1295                 1300                 1305             


Phe Leu  Ile Leu Pro Phe Gln  Arg Ile Thr Arg Leu  Lys Leu Leu 
    1310                 1315                 1320             


Leu Gln  Asn Ile Leu Lys Arg  Thr Gln Pro Gly Ser  Ser Glu Glu 
    1325                 1330                 1335             


Ala Glu  Ala Thr Lys Ala His  His Ala Leu Glu Gln  Leu Ile Arg 
    1340                 1345                 1350             


Asp Cys  Asn Asn Asn Val Gln  Ser Met Arg Arg Thr  Glu Glu Leu 
    1355                 1360                 1365             


Ile Tyr  Leu Ser Gln Lys Ile  Glu Phe Glu Cys Lys  Ile Phe Pro 
    1370                 1375                 1380             


Leu Ile  Ser Gln Ser Arg Trp  Leu Val Lys Ser Gly  Glu Leu Thr 
    1385                 1390                 1395             


Ala Leu  Glu Phe Ser Ala Ser  Pro Gly Leu Arg Arg  Lys Leu Asn 
    1400                 1405                 1410             


Thr Arg  Pro Val His Leu His  Leu Phe Asn Asp Cys  Leu Leu Leu 
    1415                 1420                 1425             


Ser Arg  Pro Arg Glu Gly Ser  Arg Phe Leu Val Phe  Asp His Ala 
    1430                 1435                 1440             


Pro Phe  Ser Ser Ile Arg Gly  Glu Lys Cys Glu Met  Lys Leu His 
    1445                 1450                 1455             


Gly Pro  His Lys Asn Leu Phe  Arg Leu Phe Leu Arg  Gln Asn Thr 
    1460                 1465                 1470             


Gln Gly  Ala Gln Ala Glu Phe  Leu Phe Arg Thr Glu  Thr Gln Ser 
    1475                 1480                 1485             


Glu Lys  Leu Arg Trp Ile Ser  Ala Leu Ala Met Pro  Arg Glu Glu 
    1490                 1495                 1500             


Leu Asp  Leu Leu Glu Cys Tyr  Asn Ser Pro Gln Val  Gln Cys Leu 
    1505                 1510                 1515             


Arg Ala  Tyr Lys Pro Arg Glu  Asn Asp Glu Leu Ala  Leu Glu Lys 
    1520                 1525                 1530             


Ala Asp  Val Val Met Val Thr  Gln Gln Ser Ser Asp  Gly Trp Leu 
    1535                 1540                 1545             


Glu Gly  Val Arg Leu Ser Asp  Gly Glu Arg Gly Trp  Phe Pro Val 
    1550                 1555                 1560             


Gln Gln  Val Glu Phe Ile Ser  Asn Pro Glu Val Arg  Ala Gln Asn 
    1565                 1570                 1575             


Leu Lys  Glu Ala His Arg Val  Lys Thr Ala Lys Leu  Gln Leu Val 
    1580                 1585                 1590             


Glu Gln  Gln Ala 
    1595         


<210>  747
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF6__Homo_sapiens__NP_004831

<400>  747

Met Asn Pro Glu Glu Gln Ile Val Thr Trp Leu Ile Ser Leu Gly Val 
1               5                   10                  15      


Leu Glu Ser Pro Lys Lys Thr Ile Cys Asp Pro Glu Glu Phe Leu Lys 
            20                  25                  30          


Ser Ser Leu Lys Asn Gly Val Val Leu Cys Lys Leu Ile Asn Arg Leu 
        35                  40                  45              


Met Pro Gly Ser Val Glu Lys Phe Cys Leu Asp Pro Gln Thr Glu Ala 
    50                  55                  60                  


Asp Cys Ile Asn Asn Ile Asn Asp Phe Leu Lys Gly Cys Ala Thr Leu 
65                  70                  75                  80  


Gln Val Glu Ile Phe Asp Pro Asp Asp Leu Tyr Ser Gly Val Asn Phe 
                85                  90                  95      


Ser Lys Val Leu Ser Thr Leu Leu Ala Val Asn Lys Ala Thr Glu Asp 
            100                 105                 110         


Gln Leu Ser Glu Arg Pro Cys Gly Arg Ser Ser Ser Leu Ser Ala Ala 
        115                 120                 125             


Asn Thr Ser Gln Thr Asn Pro Gln Gly Ala Val Ser Ser Thr Val Ser 
    130                 135                 140                 


Gly Leu Gln Arg Gln Ser Lys Thr Val Glu Met Thr Glu Asn Gly Ser 
145                 150                 155                 160 


His Gln Leu Ile Val Lys Ala Arg Phe Asn Phe Lys Gln Thr Asn Glu 
                165                 170                 175     


Asp Glu Leu Ser Val Cys Lys Gly Asp Ile Ile Tyr Val Thr Arg Val 
            180                 185                 190         


Glu Glu Gly Gly Trp Trp Glu Gly Thr Leu Asn Gly Arg Thr Gly Trp 
        195                 200                 205             


Phe Pro Ser Asn Tyr Val Arg Glu Ile Lys Ser Ser Glu Arg Pro Leu 
    210                 215                 220                 


Ser Pro Lys Ala Val Lys Gly Phe Glu Thr Ala Pro Leu Thr Lys Asn 
225                 230                 235                 240 


Tyr Tyr Thr Val Val Leu Gln Asn Ile Leu Asp Thr Glu Lys Glu Tyr 
                245                 250                 255     


Ala Lys Glu Leu Gln Ser Leu Leu Val Thr Tyr Leu Arg Pro Leu Gln 
            260                 265                 270         


Ser Asn Asn Asn Leu Ser Thr Val Glu Val Thr Ser Leu Leu Gly Asn 
        275                 280                 285             


Phe Glu Glu Val Cys Thr Phe Gln Gln Thr Leu Cys Gln Ala Leu Glu 
    290                 295                 300                 


Glu Cys Ser Lys Phe Pro Glu Asn Gln His Lys Val Gly Gly Cys Leu 
305                 310                 315                 320 


Leu Ser Leu Met Pro His Phe Lys Ser Met Tyr Leu Ala Tyr Cys Ala 
                325                 330                 335     


Asn His Pro Ser Ala Val Asn Val Leu Thr Gln His Ser Asp Glu Leu 
            340                 345                 350         


Glu Gln Phe Met Glu Asn Gln Gly Ala Ser Ser Pro Gly Ile Leu Ile 
        355                 360                 365             


Leu Thr Thr Asn Leu Ser Lys Pro Phe Met Arg Leu Glu Lys Tyr Val 
    370                 375                 380                 


Thr Leu Leu Gln Glu Leu Glu Arg His Met Glu Asp Thr His Pro Asp 
385                 390                 395                 400 


His Gln Asp Ile Leu Lys Ala Ile Val Ala Phe Lys Thr Leu Met Gly 
                405                 410                 415     


Gln Cys Gln Asp Leu Arg Lys Arg Lys Gln Leu Glu Leu Gln Ile Leu 
            420                 425                 430         


Ser Glu Pro Ile Gln Ala Trp Glu Gly Glu Asp Ile Lys Asn Leu Gly 
        435                 440                 445             


Asn Val Ile Phe Met Ser Gln Val Met Val Gln Tyr Gly Ala Cys Glu 
    450                 455                 460                 


Glu Lys Glu Glu Arg Tyr Leu Met Leu Phe Ser Asn Val Leu Ile Met 
465                 470                 475                 480 


Leu Ser Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Ile 
                485                 490                 495     


Pro Ile Ala Gly Thr Val Val Thr Arg Leu Asp Glu Ile Glu Gly Asn 
            500                 505                 510         


Asp Cys Thr Phe Glu Ile Thr Gly Asn Thr Val Glu Arg Ile Val Val 
        515                 520                 525             


His Cys Asn Asn Asn Gln Asp Phe Gln Glu Trp Leu Glu Gln Leu Asn 
    530                 535                 540                 


Arg Leu Ile Arg Gly Pro Ala Ser Cys Ser Ser Leu Ser Lys Thr Ser 
545                 550                 555                 560 


Ser Ser Ser Cys Ser Ala His Ser Ser Phe Ser Ser Thr Gly Gln Pro 
                565                 570                 575     


Arg Gly Pro Leu Glu Pro Pro Gln Ile Ile Lys Pro Trp Ser Leu Ser 
            580                 585                 590         


Cys Leu Arg Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Gly Tyr 
        595                 600                 605             


Lys Glu Arg Met Ser Tyr Ile Leu Lys Glu Ser Ser Lys Ser Pro Lys 
    610                 615                 620                 


Thr Met Lys Lys Phe Leu His Lys Arg Lys Thr Glu Arg Lys Pro Ser 
625                 630                 635                 640 


Glu Glu Glu Tyr Val Ile Arg Lys Ser Thr Ala Ala Leu Glu Glu Asp 
                645                 650                 655     


Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr Cys Thr Ser Ala Asn Phe 
            660                 665                 670         


Gln Gln Gly His Gly Ser Ser Thr Arg Lys Asp Ser Ile Pro Gln Val 
        675                 680                 685             


Leu Leu Pro Glu Glu Glu Lys Leu Ile Ile Glu Glu Thr Arg Ser Asn 
    690                 695                 700                 


Gly Gln Thr Ile Met Glu Glu Lys Ser Leu Val Asp Thr Val Tyr Ala 
705                 710                 715                 720 


Leu Lys Asp Glu Val Arg Glu Leu Lys Gln Glu Asn Lys Arg Met Lys 
                725                 730                 735     


Gln Cys Leu Glu Glu Glu Leu Lys Ser Arg Arg Asp Leu Glu Lys Leu 
            740                 745                 750         


Val Arg Arg Leu Leu Lys Gln Thr Asp Glu Cys Ile Arg Gly Glu Ser 
        755                 760                 765             


Ser Ser Lys Thr Ser Ile Leu Pro 
    770                 775     


<210>  748
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF7__Homo_sapiens__NP_001106983

<400>  748

Met Asn Ser Ala Glu Gln Thr Val Thr Trp Leu Ile Thr Leu Gly Val 
1               5                   10                  15      


Leu Glu Ser Pro Lys Lys Thr Ile Ser Asp Pro Glu Gly Phe Leu Gln 
            20                  25                  30          


Ala Ser Leu Lys Asp Gly Val Val Leu Cys Arg Leu Leu Glu Arg Leu 
        35                  40                  45              


Leu Pro Gly Thr Ile Glu Lys Val Tyr Pro Glu Pro Arg Ser Glu Ser 
    50                  55                  60                  


Glu Cys Leu Ser Asn Ile Arg Glu Phe Leu Arg Gly Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Arg Leu Glu Leu Leu Phe Pro Pro Ser Gln Pro Pro Gln His Leu 
                85                  90                  95      


Val Thr Thr Ile Leu Leu Ser Ala Ser Thr Phe Asp Ala Asn Asp Leu 
            100                 105                 110         


Tyr Gln Gly Gln Asn Phe Asn Lys Val Leu Ser Ser Leu Val Thr Leu 
        115                 120                 125             


Asn Lys Val Thr Ala Asp Ile Gly Leu Gly Ser Asp Ser Val Cys Ala 
    130                 135                 140                 


Arg Pro Ser Ser His Arg Ile Lys Ser Phe Asp Ser Leu Gly Ser Gln 
145                 150                 155                 160 


Ser Leu His Thr Arg Thr Ser Lys Leu Phe Gln Gly Gln Tyr Arg Ser 
                165                 170                 175     


Leu Asp Met Thr Asp Asn Ser Asn Asn Gln Leu Val Val Arg Ala Lys 
            180                 185                 190         


Phe Asn Phe Gln Gln Thr Asn Glu Asp Glu Leu Ser Phe Ser Lys Gly 
        195                 200                 205             


Asp Val Ile His Val Thr Arg Val Glu Glu Gly Gly Trp Trp Glu Gly 
    210                 215                 220                 


Thr Leu Asn Gly Arg Thr Gly Trp Phe Pro Ser Asn Tyr Val Arg Glu 
225                 230                 235                 240 


Val Lys Ala Ser Glu Lys Pro Val Ser Pro Lys Ser Gly Thr Leu Lys 
                245                 250                 255     


Ser Pro Pro Lys Gly Phe Asp Thr Thr Ala Ile Asn Lys Ser Tyr Tyr 
            260                 265                 270         


Asn Val Val Leu Gln Asn Ile Leu Glu Thr Glu Asn Glu Tyr Ser Lys 
        275                 280                 285             


Glu Leu Gln Thr Val Leu Ser Thr Tyr Leu Arg Pro Leu Gln Thr Ser 
    290                 295                 300                 


Glu Lys Leu Ser Ser Ala Asn Ile Ser Tyr Leu Met Gly Asn Leu Glu 
305                 310                 315                 320 


Glu Ile Cys Ser Phe Gln Gln Met Leu Val Gln Ser Leu Glu Glu Cys 
                325                 330                 335     


Thr Lys Leu Pro Glu Ala Gln Gln Arg Val Gly Gly Cys Phe Leu Asn 
            340                 345                 350         


Leu Met Pro Gln Met Lys Thr Leu Tyr Leu Thr Tyr Cys Ala Asn His 
        355                 360                 365             


Pro Ser Ala Val Asn Val Leu Thr Glu His Ser Glu Glu Leu Gly Glu 
    370                 375                 380                 


Phe Met Glu Thr Lys Gly Ala Ser Ser Pro Gly Ile Leu Val Leu Thr 
385                 390                 395                 400 


Thr Gly Leu Ser Lys Pro Phe Met Arg Leu Asp Lys Tyr Pro Thr Leu 
                405                 410                 415     


Leu Lys Glu Leu Glu Arg His Met Glu Asp Tyr His Thr Asp Arg Gln 
            420                 425                 430         


Asp Ile Gln Lys Ser Met Ala Ala Phe Lys Asn Leu Ser Ala Gln Cys 
        435                 440                 445             


Gln Glu Val Arg Lys Arg Lys Glu Leu Glu Leu Gln Ile Leu Thr Glu 
    450                 455                 460                 


Ala Ile Arg Asn Trp Glu Gly Asp Asp Ile Lys Thr Leu Gly Asn Val 
465                 470                 475                 480 


Thr Tyr Met Ser Gln Val Leu Ile Gln Cys Ala Gly Ser Glu Glu Lys 
                485                 490                 495     


Asn Glu Arg Tyr Leu Leu Leu Phe Pro Asn Val Leu Leu Met Leu Ser 
            500                 505                 510         


Ala Ser Pro Arg Met Ser Gly Phe Ile Tyr Gln Gly Lys Leu Pro Thr 
        515                 520                 525             


Thr Gly Met Thr Ile Thr Lys Leu Glu Asp Ser Glu Asn His Arg Asn 
    530                 535                 540                 


Ala Phe Glu Ile Ser Gly Ser Met Ile Glu Arg Ile Leu Val Ser Cys 
545                 550                 555                 560 


Asn Asn Gln Gln Asp Leu Gln Glu Trp Val Glu His Leu Gln Lys Gln 
                565                 570                 575     


Thr Lys Val Thr Ser Val Gly Asn Pro Thr Ile Lys Pro His Ser Val 
            580                 585                 590         


Pro Ser His Thr Leu Pro Ser His Pro Val Thr Pro Ser Ser Lys His 
        595                 600                 605             


Ala Asp Ser Lys Pro Ala Pro Leu Thr Pro Ala Tyr His Thr Leu Pro 
    610                 615                 620                 


His Pro Ser His His Gly Thr Pro His Thr Thr Ile Asn Trp Gly Pro 
625                 630                 635                 640 


Leu Glu Pro Pro Lys Thr Pro Lys Pro Trp Ser Leu Ser Cys Leu Arg 
                645                 650                 655     


Pro Ala Pro Pro Leu Arg Pro Ser Ala Ala Leu Cys Tyr Lys Glu Asp 
            660                 665                 670         


Leu Ser Lys Ser Pro Lys Thr Met Lys Lys Leu Leu Pro Lys Arg Lys 
        675                 680                 685             


Pro Glu Arg Lys Pro Ser Asp Glu Glu Phe Ala Ser Arg Lys Ser Thr 
    690                 695                 700                 


Ala Ala Leu Glu Glu Asp Ala Gln Ile Leu Lys Val Ile Glu Ala Tyr 
705                 710                 715                 720 


Cys Thr Ser Ala Lys Thr Arg Gln Thr Leu Asn Ser Thr Trp Gln Gly 
                725                 730                 735     


Thr Asp Leu Met His Asn His Val Leu Ala Asp Asp Asp Gln Pro Ser 
            740                 745                 750         


Leu Asp Ser Leu Gly Arg Arg Ser Ser Leu Ser Arg Leu Glu Pro Ser 
        755                 760                 765             


Asp Leu Ser Glu Asp Ser Asp Tyr Asp Ser Ile Trp Thr Ala His Ser 
    770                 775                 780                 


Tyr Arg Met Gly Ser Thr Ser Arg Lys Ser Cys Cys Ser Tyr Ile Ser 
785                 790                 795                 800 


His Gln Asn 
            


<210>  749
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARHGEF9__Homo_sapiens__NP_001166950

<400>  749

Met Gln Trp Ile Arg Gly Gly Ser Gly Met Leu Trp Val Asn Gln Glu 
1               5                   10                  15      


Asp Glu Val Glu Glu Gly Pro Ser Asp Val Gln Asn Gly His Leu Asp 
            20                  25                  30          


Pro Asn Ser Asp Cys Leu Cys Leu Gly Arg Pro Leu Gln Asn Arg Asp 
        35                  40                  45              


Gln Met Arg Ala Asn Val Ile Asn Glu Ile Met Ser Thr Glu Arg His 
    50                  55                  60                  


Tyr Ile Lys His Leu Lys Asp Ile Cys Glu Gly Tyr Leu Lys Gln Cys 
65                  70                  75                  80  


Arg Lys Arg Arg Asp Met Phe Ser Asp Glu Gln Leu Lys Val Ile Phe 
                85                  90                  95      


Gly Asn Ile Glu Asp Ile Tyr Arg Phe Gln Met Gly Phe Val Arg Asp 
            100                 105                 110         


Leu Glu Lys Gln Tyr Asn Asn Asp Asp Pro His Leu Ser Glu Ile Gly 
        115                 120                 125             


Pro Cys Phe Leu Glu His Gln Asp Gly Phe Trp Ile Tyr Ser Glu Tyr 
    130                 135                 140                 


Cys Asn Asn His Leu Asp Ala Cys Met Glu Leu Ser Lys Leu Met Lys 
145                 150                 155                 160 


Asp Ser Arg Tyr Gln His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln 
                165                 170                 175     


Met Ile Asp Ile Ala Ile Asp Gly Phe Leu Leu Thr Pro Val Gln Lys 
            180                 185                 190         


Ile Cys Lys Tyr Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Thr Ala 
        195                 200                 205             


Gln Asp His Ser Asp Tyr Arg Tyr Val Ala Ala Ala Leu Ala Val Met 
    210                 215                 220                 


Arg Asn Val Thr Gln Gln Ile Asn Glu Arg Lys Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Ile Asp Lys Ile Ala Gln Trp Gln Ala Ser Val Leu Asp Trp Glu Gly 
                245                 250                 255     


Glu Asp Ile Leu Asp Arg Ser Ser Glu Leu Ile Tyr Thr Gly Glu Met 
            260                 265                 270         


Ala Trp Ile Tyr Gln Pro Tyr Gly Arg Asn Gln Gln Arg Val Phe Phe 
        275                 280                 285             


Leu Phe Asp His Gln Met Val Leu Cys Lys Lys Asp Leu Ile Arg Arg 
    290                 295                 300                 


Asp Ile Leu Tyr Tyr Lys Gly Arg Ile Asp Met Asp Lys Tyr Glu Val 
305                 310                 315                 320 


Val Asp Ile Glu Asp Gly Arg Asp Asp Asp Phe Asn Val Ser Met Lys 
                325                 330                 335     


Asn Ala Phe Lys Leu His Asn Lys Glu Thr Glu Glu Ile His Leu Phe 
            340                 345                 350         


Phe Ala Lys Lys Leu Glu Glu Lys Ile Arg Trp Leu Arg Ala Phe Arg 
        355                 360                 365             


Glu Glu Arg Lys Met Val Gln Glu Asp Glu Lys Ile Gly Phe Glu Ile 
    370                 375                 380                 


Ser Glu Asn Gln Lys Arg Gln Ala Ala Met Thr Val Arg Lys Val Pro 
385                 390                 395                 400 


Lys Gln Lys Gly Val Asn Ser Ala Arg Ser Val Pro Pro Ser Tyr Pro 
                405                 410                 415     


Pro Pro Gln Asp Pro Leu Asn His Gly Gln Tyr Leu Val Pro Asp Gly 
            420                 425                 430         


Ile Ala Gln Ser Gln Val Phe Glu Phe Thr Glu Pro Lys Arg Ser Gln 
        435                 440                 445             


Ser Pro Phe Trp Gln Asn Phe Ser Arg Leu Thr Pro Phe Lys Lys 
    450                 455                 460             


<210>  750
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AR__Homo_sapiens__NP_000035

<400>  750

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  751
<211>  2236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARID1B__Homo_sapiens__NP_059989

<400>  751

Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Thr His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Thr Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Thr Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Thr Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Thr 
                405                 410                 415     


Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Thr Pro Gly Pro Thr Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Thr Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr 
            580                 585                 590         


Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro 
        595                 600                 605             


His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg 
    610                 615                 620                 


Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Thr Arg Ser 
625                 630                 635                 640 


Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu 
                645                 650                 655     


Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile 
            660                 665                 670         


Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser Ala Val Ser 
        675                 680                 685             


Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln 
    690                 695                 700                 


Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly 
705                 710                 715                 720 


Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser 
                725                 730                 735     


Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro 
            740                 745                 750         


Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu 
        755                 760                 765             


Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Thr Gln 
    770                 775                 780                 


Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr Gly Pro Ser 
785                 790                 795                 800 


Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser 
                805                 810                 815     


Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln Met Ser 
            820                 825                 830         


Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly 
        835                 840                 845             


Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser 
    850                 855                 860                 


Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala 
865                 870                 875                 880 


Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe 
                885                 890                 895     


Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly Met Ser Gln 
            900                 905                 910         


Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys 
        915                 920                 925             


Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala 
    930                 935                 940                 


Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met 
945                 950                 955                 960 


Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu 
                965                 970                 975     


Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn 
            980                 985                 990         


Ser Ser Ala Ala Ser Val Gly Leu  Ala Asp Met Met Ser  Pro Gly Glu 
        995                 1000                 1005             


Ser Lys  Leu Pro Leu Pro Leu  Lys Ala Asp Gly Lys  Glu Glu Gly 
    1010                 1015                 1020             


Thr Pro  Gln Pro Glu Ser Lys  Ser Lys Lys Ser Ser  Ser Ser Thr 
    1025                 1030                 1035             


Thr Thr  Gly Glu Lys Ile Thr  Lys Val Tyr Glu Leu  Gly Asn Glu 
    1040                 1045                 1050             


Pro Glu  Arg Lys Leu Trp Val  Asp Arg Tyr Leu Thr  Phe Met Glu 
    1055                 1060                 1065             


Glu Arg  Gly Ser Pro Val Ser  Ser Leu Pro Ala Val  Gly Lys Lys 
    1070                 1075                 1080             


Pro Leu  Asp Leu Phe Arg Leu  Tyr Val Cys Val Lys  Glu Ile Gly 
    1085                 1090                 1095             


Gly Leu  Ala Gln Val Asn Lys  Asn Lys Lys Trp Arg  Glu Leu Ala 
    1100                 1105                 1110             


Thr Asn  Leu Asn Val Gly Thr  Ser Ser Ser Ala Ala  Ser Ser Leu 
    1115                 1120                 1125             


Lys Lys  Gln Tyr Ile Gln Tyr  Leu Phe Ala Phe Glu  Cys Lys Ile 
    1130                 1135                 1140             


Glu Arg  Gly Glu Glu Pro Pro  Pro Glu Val Phe Ser  Thr Gly Asp 
    1145                 1150                 1155             


Thr Lys  Lys Gln Pro Lys Leu  Gln Pro Pro Ser Pro  Ala Asn Ser 
    1160                 1165                 1170             


Gly Ser  Leu Gln Gly Pro Gln  Thr Pro Gln Ser Thr  Gly Ser Asn 
    1175                 1180                 1185             


Ser Met  Ala Glu Val Pro Gly  Asp Leu Lys Pro Pro  Thr Pro Ala 
    1190                 1195                 1200             


Ser Thr  Pro His Gly Gln Met  Thr Pro Met Gln Gly  Gly Arg Ser 
    1205                 1210                 1215             


Ser Thr  Ile Ser Val His Asp  Pro Phe Ser Asp Val  Ser Asp Ser 
    1220                 1225                 1230             


Ser Phe  Pro Lys Arg Asn Ser  Met Thr Pro Asn Ala  Pro Tyr Gln 
    1235                 1240                 1245             


Gln Gly  Met Ser Met Pro Asp  Val Met Gly Arg Met  Pro Tyr Glu 
    1250                 1255                 1260             


Pro Asn  Lys Asp Pro Phe Gly  Gly Met Arg Lys Val  Pro Gly Ser 
    1265                 1270                 1275             


Ser Glu  Pro Phe Met Thr Gln  Gly Gln Met Pro Asn  Ser Ser Met 
    1280                 1285                 1290             


Gln Asp  Met Tyr Asn Gln Ser  Pro Ser Gly Ala Met  Ser Asn Leu 
    1295                 1300                 1305             


Gly Met  Gly Gln Arg Gln Gln  Phe Pro Tyr Gly Ala  Ser Tyr Asp 
    1310                 1315                 1320             


Arg Arg  His Glu Pro Tyr Gly  Gln Gln Tyr Pro Gly  Gln Gly Pro 
    1325                 1330                 1335             


Pro Ser  Gly Gln Pro Pro Tyr  Gly Gly His Gln Pro  Gly Leu Tyr 
    1340                 1345                 1350             


Pro Gln  Gln Pro Asn Tyr Lys  Arg His Met Asp Gly  Met Tyr Gly 
    1355                 1360                 1365             


Pro Pro  Ala Lys Arg His Glu  Gly Asp Met Tyr Asn  Met Gln Tyr 
    1370                 1375                 1380             


Ser Ser  Gln Gln Gln Glu Met  Tyr Asn Gln Tyr Gly  Gly Ser Tyr 
    1385                 1390                 1395             


Ser Gly  Pro Asp Arg Arg Pro  Ile Gln Gly Gln Tyr  Pro Tyr Pro 
    1400                 1405                 1410             


Tyr Ser  Arg Glu Arg Met Gln  Gly Pro Gly Gln Ile  Gln Thr His 
    1415                 1420                 1425             


Gly Ile  Pro Pro Gln Met Met  Gly Gly Pro Leu Gln  Ser Ser Ser 
    1430                 1435                 1440             


Ser Glu  Gly Pro Gln Gln Asn  Met Trp Ala Ala Arg  Asn Asp Met 
    1445                 1450                 1455             


Pro Tyr  Pro Tyr Gln Asn Arg  Gln Gly Pro Gly Gly  Pro Thr Gln 
    1460                 1465                 1470             


Ala Pro  Pro Tyr Pro Gly Met  Asn Arg Thr Asp Asp  Met Met Val 
    1475                 1480                 1485             


Pro Asp  Gln Arg Ile Asn His  Glu Ser Gln Trp Pro  Ser His Val 
    1490                 1495                 1500             


Ser Gln  Arg Gln Pro Tyr Met  Ser Ser Ser Ala Ser  Met Gln Pro 
    1505                 1510                 1515             


Ile Thr  Arg Pro Pro Gln Pro  Ser Tyr Gln Thr Pro  Pro Ser Leu 
    1520                 1525                 1530             


Pro Asn  His Ile Ser Arg Ala  Pro Ser Pro Ala Ser  Phe Gln Arg 
    1535                 1540                 1545             


Ser Leu  Glu Asn Arg Met Ser  Pro Ser Lys Ser Pro  Phe Leu Pro 
    1550                 1555                 1560             


Ser Met  Lys Met Gln Lys Val  Met Pro Thr Val Pro  Thr Ser Gln 
    1565                 1570                 1575             


Val Thr  Gly Pro Pro Pro Gln  Pro Pro Pro Ile Arg  Arg Glu Ile 
    1580                 1585                 1590             


Thr Phe  Pro Pro Gly Ser Val  Glu Ala Ser Gln Pro  Val Leu Lys 
    1595                 1600                 1605             


Gln Arg  Arg Lys Ile Thr Ser  Lys Asp Ile Val Thr  Pro Glu Ala 
    1610                 1615                 1620             


Trp Arg  Val Met Met Ser Leu  Lys Ser Gly Leu Leu  Ala Glu Ser 
    1625                 1630                 1635             


Thr Trp  Ala Leu Asp Thr Ile  Asn Ile Leu Leu Tyr  Asp Asp Ser 
    1640                 1645                 1650             


Thr Val  Ala Thr Phe Asn Leu  Ser Gln Leu Ser Gly  Phe Leu Glu 
    1655                 1660                 1665             


Leu Leu  Val Glu Tyr Phe Arg  Lys Cys Leu Ile Asp  Ile Phe Gly 
    1670                 1675                 1680             


Ile Leu  Met Glu Tyr Glu Val  Gly Asp Pro Ser Gln  Lys Ala Leu 
    1685                 1690                 1695             


Asp His  Asn Ala Ala Arg Lys  Asp Asp Ser Gln Ser  Leu Ala Asp 
    1700                 1705                 1710             


Asp Ser  Gly Lys Glu Glu Glu  Asp Ala Glu Cys Ile  Asp Asp Asp 
    1715                 1720                 1725             


Glu Glu  Asp Glu Glu Asp Glu  Glu Glu Asp Ser Glu  Lys Thr Glu 
    1730                 1735                 1740             


Ser Asp  Glu Lys Ser Ser Ile  Ala Leu Thr Ala Pro  Asp Ala Ala 
    1745                 1750                 1755             


Ala Asp  Pro Lys Glu Lys Pro  Lys Gln Ala Ser Lys  Phe Asp Lys 
    1760                 1765                 1770             


Leu Pro  Ile Lys Ile Val Lys  Lys Asn Asn Leu Phe  Val Val Asp 
    1775                 1780                 1785             


Arg Ser  Asp Lys Leu Gly Arg  Val Gln Glu Phe Asn  Ser Gly Leu 
    1790                 1795                 1800             


Leu His  Trp Gln Leu Gly Gly  Gly Asp Thr Thr Glu  His Ile Gln 
    1805                 1810                 1815             


Thr His  Phe Glu Ser Lys Met  Glu Ile Pro Pro Arg  Arg Arg Pro 
    1820                 1825                 1830             


Pro Pro  Pro Leu Ser Ser Ala  Gly Arg Lys Lys Glu  Gln Glu Gly 
    1835                 1840                 1845             


Lys Gly  Asp Ser Glu Glu Gln  Gln Glu Lys Ser Ile  Ile Ala Thr 
    1850                 1855                 1860             


Ile Asp  Asp Val Leu Ser Ala  Arg Pro Gly Ala Leu  Pro Glu Asp 
    1865                 1870                 1875             


Ala Asn  Pro Gly Pro Gln Thr  Glu Ser Ser Lys Phe  Pro Phe Gly 
    1880                 1885                 1890             


Ile Gln  Gln Ala Lys Ser His  Arg Asn Ile Lys Leu  Leu Glu Asp 
    1895                 1900                 1905             


Glu Pro  Arg Ser Arg Asp Glu  Thr Pro Leu Cys Thr  Ile Ala His 
    1910                 1915                 1920             


Trp Gln  Asp Ser Leu Ala Lys  Arg Cys Ile Cys Val  Ser Asn Ile 
    1925                 1930                 1935             


Val Arg  Ser Leu Ser Phe Val  Pro Gly Asn Asp Ala  Glu Met Ser 
    1940                 1945                 1950             


Lys His  Pro Gly Leu Val Leu  Ile Leu Gly Lys Leu  Ile Leu Leu 
    1955                 1960                 1965             


His His  Glu His Pro Glu Arg  Lys Arg Ala Pro Gln  Thr Tyr Glu 
    1970                 1975                 1980             


Lys Glu  Glu Asp Glu Asp Lys  Gly Val Ala Cys Ser  Lys Asp Glu 
    1985                 1990                 1995             


Trp Trp  Trp Asp Cys Leu Glu  Val Leu Arg Asp Asn  Thr Leu Val 
    2000                 2005                 2010             


Thr Leu  Ala Asn Ile Ser Gly  Gln Leu Asp Leu Ser  Ala Tyr Thr 
    2015                 2020                 2025             


Glu Ser  Ile Cys Leu Pro Ile  Leu Asp Gly Leu Leu  His Trp Met 
    2030                 2035                 2040             


Val Cys  Pro Ser Ala Glu Ala  Gln Asp Pro Phe Pro  Thr Val Gly 
    2045                 2050                 2055             


Pro Asn  Ser Val Leu Ser Pro  Gln Arg Leu Val Leu  Glu Thr Leu 
    2060                 2065                 2070             


Cys Lys  Leu Ser Ile Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala 
    2075                 2080                 2085             


Thr Pro  Pro Phe Ser Arg Gln  Glu Lys Phe Tyr Ala  Thr Leu Val 
    2090                 2095                 2100             


Arg Tyr  Val Gly Asp Arg Lys  Asn Pro Val Cys Arg  Glu Met Ser 
    2105                 2110                 2115             


Met Ala  Leu Leu Ser Asn Leu  Ala Gln Gly Asp Ala  Leu Ala Ala 
    2120                 2125                 2130             


Arg Ala  Ile Ala Val Gln Lys  Gly Ser Ile Gly Asn  Leu Ile Ser 
    2135                 2140                 2145             


Phe Leu  Glu Asp Gly Val Thr  Met Ala Gln Tyr Gln  Gln Ser Gln 
    2150                 2155                 2160             


His Asn  Leu Met His Met Gln  Pro Pro Pro Leu Glu  Pro Pro Ser 
    2165                 2170                 2175             


Val Asp  Met Met Cys Arg Ala  Ala Lys Ala Leu Leu  Ala Met Ala 
    2180                 2185                 2190             


Arg Val  Asp Glu Asn Arg Ser  Glu Phe Leu Leu His  Glu Gly Arg 
    2195                 2200                 2205             


Leu Leu  Asp Ile Ser Ile Ser  Ala Val Leu Asn Ser  Leu Val Ala 
    2210                 2215                 2220             


Ser Val  Ile Cys Asp Val Leu  Phe Gln Ile Gly Gln  Leu 
    2225                 2230                 2235     


<210>  752
<211>  1835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARID2__Homo_sapiens__NP_689854

<400>  752

Met Ala Asn Ser Thr Gly Lys Ala Pro Pro Asp Glu Arg Arg Lys Gly 
1               5                   10                  15      


Leu Ala Phe Leu Asp Glu Leu Arg Gln Phe His His Ser Arg Gly Ser 
            20                  25                  30          


Pro Phe Lys Lys Ile Pro Ala Val Gly Gly Lys Glu Leu Asp Leu His 
        35                  40                  45              


Gly Leu Tyr Thr Arg Val Thr Thr Leu Gly Gly Phe Ala Lys Val Ser 
    50                  55                  60                  


Glu Lys Asn Gln Trp Gly Glu Ile Val Glu Glu Phe Asn Phe Pro Arg 
65                  70                  75                  80  


Ser Cys Ser Asn Ala Ala Phe Ala Leu Lys Gln Tyr Tyr Leu Arg Tyr 
                85                  90                  95      


Leu Glu Lys Tyr Glu Lys Val His His Phe Gly Glu Asp Asp Asp Glu 
            100                 105                 110         


Val Pro Pro Gly Asn Pro Lys Pro Gln Leu Pro Ile Gly Ala Ile Pro 
        115                 120                 125             


Ser Ser Tyr Asn Tyr Gln Gln His Ser Val Ser Asp Tyr Leu Arg Gln 
    130                 135                 140                 


Ser Tyr Gly Leu Ser Met Asp Phe Asn Ser Pro Asn Asp Tyr Asn Lys 
145                 150                 155                 160 


Leu Val Leu Ser Leu Leu Ser Gly Leu Pro Asn Glu Val Asp Phe Ala 
                165                 170                 175     


Ile Asn Val Cys Thr Leu Leu Ser Asn Glu Ser Lys His Val Met Gln 
            180                 185                 190         


Leu Glu Lys Asp Pro Lys Ile Ile Thr Leu Leu Leu Ala Asn Ala Gly 
        195                 200                 205             


Val Phe Asp Asp Thr Leu Gly Ser Phe Ser Thr Val Phe Gly Glu Glu 
    210                 215                 220                 


Trp Lys Glu Lys Thr Asp Arg Asp Phe Val Lys Phe Trp Lys Asp Ile 
225                 230                 235                 240 


Val Asp Asp Asn Glu Val Arg Asp Leu Ile Ser Asp Arg Asn Lys Ser 
                245                 250                 255     


His Glu Gly Thr Ser Gly Glu Trp Ile Trp Glu Ser Leu Phe His Pro 
            260                 265                 270         


Pro Arg Lys Leu Gly Ile Asn Asp Ile Glu Gly Gln Arg Val Leu Gln 
        275                 280                 285             


Ile Ala Val Ile Leu Arg Asn Leu Ser Phe Glu Glu Gly Asn Val Lys 
    290                 295                 300                 


Leu Leu Ala Ala Asn Arg Thr Cys Leu Arg Phe Leu Leu Leu Ser Ala 
305                 310                 315                 320 


His Ser His Phe Ile Ser Leu Arg Gln Leu Gly Leu Asp Thr Leu Gly 
                325                 330                 335     


Asn Ile Ala Ala Glu Leu Leu Leu Asp Pro Val Asp Phe Lys Thr Thr 
            340                 345                 350         


His Leu Met Phe His Thr Val Thr Lys Cys Leu Met Ser Arg Asp Arg 
        355                 360                 365             


Phe Leu Lys Met Arg Gly Met Glu Ile Leu Gly Asn Leu Cys Lys Ala 
    370                 375                 380                 


Glu Asp Asn Gly Val Leu Ile Cys Glu Tyr Val Asp Gln Asp Ser Tyr 
385                 390                 395                 400 


Arg Glu Ile Ile Cys His Leu Thr Leu Pro Asp Val Leu Leu Val Ile 
                405                 410                 415     


Ser Thr Leu Glu Val Leu Tyr Met Leu Thr Glu Met Gly Asp Val Ala 
            420                 425                 430         


Cys Thr Lys Ile Ala Lys Val Glu Lys Ser Ile Asp Met Leu Val Cys 
        435                 440                 445             


Leu Val Ser Met Asp Ile Gln Met Phe Gly Pro Asp Ala Leu Ala Ala 
    450                 455                 460                 


Val Lys Leu Ile Glu His Pro Ser Ser Ser His Gln Met Leu Ser Glu 
465                 470                 475                 480 


Ile Arg Pro Gln Ala Ile Glu Gln Val Gln Thr Gln Thr His Val Ala 
                485                 490                 495     


Ser Ala Pro Ala Ser Arg Ala Val Val Ala Gln His Val Ala Pro Pro 
            500                 505                 510         


Pro Gly Ile Val Glu Ile Asp Ser Glu Lys Phe Ala Cys Gln Trp Leu 
        515                 520                 525             


Asn Ala His Phe Glu Val Asn Pro Asp Cys Ser Val Ser Arg Ala Glu 
    530                 535                 540                 


Met Tyr Ser Glu Tyr Leu Ser Thr Cys Ser Lys Leu Ala Arg Gly Gly 
545                 550                 555                 560 


Ile Leu Thr Ser Thr Gly Phe Tyr Lys Cys Leu Arg Thr Val Phe Pro 
                565                 570                 575     


Asn His Thr Val Lys Arg Val Glu Asp Ser Ser Ser Asn Gly Gln Ala 
            580                 585                 590         


His Ile His Val Val Gly Val Lys Arg Arg Ala Ile Pro Leu Pro Ile 
        595                 600                 605             


Gln Met Tyr Tyr Gln Gln Gln Pro Val Ser Thr Ser Val Val Arg Val 
    610                 615                 620                 


Asp Ser Val Pro Asp Val Ser Pro Ala Pro Ser Pro Ala Gly Ile Pro 
625                 630                 635                 640 


His Gly Ser Gln Thr Ile Gly Asn His Phe Gln Arg Thr Pro Val Ala 
                645                 650                 655     


Asn Gln Ser Ser Asn Leu Thr Ala Thr Gln Met Ser Phe Pro Val Gln 
            660                 665                 670         


Gly Val His Thr Val Ala Gln Thr Val Ser Arg Ile Pro Gln Asn Pro 
        675                 680                 685             


Ser Pro His Thr His Gln Gln Gln Asn Ala Pro Val Thr Val Ile Gln 
    690                 695                 700                 


Ser Lys Ala Pro Ile Pro Cys Glu Val Val Lys Ala Thr Val Ile Gln 
705                 710                 715                 720 


Asn Ser Ile Pro Gln Thr Gly Val Pro Val Ser Ile Ala Val Gly Gly 
                725                 730                 735     


Gly Pro Pro Gln Ser Ser Val Val Gln Asn His Ser Thr Gly Pro Gln 
            740                 745                 750         


Pro Val Thr Val Val Asn Ser Gln Thr Leu Leu His His Pro Ser Val 
        755                 760                 765             


Ile Pro Gln Gln Ser Pro Leu His Thr Val Val Pro Gly Gln Ile Pro 
    770                 775                 780                 


Ser Gly Thr Pro Val Thr Val Ile Gln Gln Ala Val Pro Gln Ser His 
785                 790                 795                 800 


Met Phe Gly Arg Val Gln Asn Ile Pro Ala Cys Thr Ser Thr Val Ser 
                805                 810                 815     


Gln Gly Gln Gln Leu Ile Thr Thr Ser Pro Gln Pro Val Gln Thr Ser 
            820                 825                 830         


Ser Gln Gln Thr Ser Ala Gly Ser Gln Ser Gln Asp Thr Val Ile Ile 
        835                 840                 845             


Ala Pro Pro Gln Tyr Val Thr Thr Ser Ala Ser Asn Ile Val Ser Ala 
    850                 855                 860                 


Thr Ser Val Gln Asn Phe Gln Val Ala Thr Gly Gln Met Val Thr Ile 
865                 870                 875                 880 


Ala Gly Val Pro Ser Pro Gln Ala Ser Arg Val Gly Phe Gln Asn Ile 
                885                 890                 895     


Ala Pro Lys Pro Leu Pro Ser Gln Gln Val Ser Ser Thr Val Val Gln 
            900                 905                 910         


Gln Pro Ile Gln Gln Pro Gln Gln Pro Thr Gln Gln Ser Val Val Ile 
        915                 920                 925             


Val Ser Gln Pro Ala Gln Gln Gly Gln Thr Tyr Ala Pro Ala Ile His 
    930                 935                 940                 


Gln Ile Val Leu Ala Asn Pro Ala Ala Leu Pro Ala Gly Gln Thr Val 
945                 950                 955                 960 


Gln Leu Thr Gly Gln Pro Asn Ile Thr Pro Ser Ser Ser Pro Ser Pro 
                965                 970                 975     


Val Pro Ala Thr Asn Asn Gln Val Pro Thr Ala Met Ser Ser Ser Ser 
            980                 985                 990         


Thr Pro Gln Ser Gln Gly Pro Pro  Pro Thr Val Ser Gln  Met Leu Ser 
        995                 1000                 1005             


Val Lys  Arg Gln Gln Gln Gln  Gln His Ser Pro Ala  Pro Pro Pro 
    1010                 1015                 1020             


Gln Gln  Val Gln Val Gln Val  Gln Gln Pro Gln Gln  Val Gln Met 
    1025                 1030                 1035             


Gln Val  Gln Pro Gln Gln Ser  Asn Ala Gly Val Gly  Gln Pro Ala 
    1040                 1045                 1050             


Ser Gly  Glu Ser Ser Leu Ile  Lys Gln Leu Leu Leu  Pro Lys Arg 
    1055                 1060                 1065             


Gly Pro  Ser Thr Pro Gly Gly  Lys Leu Ile Leu Pro  Ala Pro Gln 
    1070                 1075                 1080             


Ile Pro  Pro Pro Asn Asn Ala  Arg Ala Pro Ser Pro  Gln Val Val 
    1085                 1090                 1095             


Tyr Gln  Val Ala Ser Asn Gln  Ala Ala Gly Phe Gly  Val Gln Gly 
    1100                 1105                 1110             


Gln Thr  Pro Ala Gln Gln Leu  Leu Val Gly Gln Gln  Asn Val Gln 
    1115                 1120                 1125             


Leu Val  Pro Ser Ala Met Pro  Pro Ser Gly Gly Val  Gln Thr Val 
    1130                 1135                 1140             


Pro Ile  Ser Asn Leu Gln Ile  Leu Pro Gly Pro Leu  Ile Ser Asn 
    1145                 1150                 1155             


Ser Pro  Ala Thr Ile Phe Gln  Gly Thr Ser Gly Asn  Gln Val Thr 
    1160                 1165                 1170             


Ile Thr  Val Val Pro Asn Thr  Ser Phe Ala Pro Ala  Thr Val Ser 
    1175                 1180                 1185             


Gln Gly  Asn Ala Thr Gln Leu  Ile Ala Pro Ala Gly  Ile Thr Met 
    1190                 1195                 1200             


Ser Gly  Thr Gln Thr Gly Val  Gly Leu Pro Val Gln  Thr Leu Pro 
    1205                 1210                 1215             


Ala Thr  Gln Ala Ser Pro Ala  Gly Gln Ser Ser Cys  Thr Thr Ala 
    1220                 1225                 1230             


Thr Pro  Pro Phe Lys Gly Asp  Lys Ile Ile Cys Gln  Lys Glu Glu 
    1235                 1240                 1245             


Glu Ala  Lys Glu Ala Thr Gly  Leu His Val His Glu  Arg Lys Ile 
    1250                 1255                 1260             


Glu Val  Met Glu Asn Pro Ser  Cys Arg Arg Gly Ala  Thr Asn Thr 
    1265                 1270                 1275             


Ser Asn  Gly Asp Thr Lys Glu  Asn Glu Met His Val  Gly Ser Leu 
    1280                 1285                 1290             


Leu Asn  Gly Arg Lys Tyr Ser  Asp Ser Ser Leu Pro  Pro Ser Asn 
    1295                 1300                 1305             


Ser Gly  Lys Ile Gln Ser Glu  Thr Asn Gln Cys Ser  Leu Ile Ser 
    1310                 1315                 1320             


Asn Gly  Pro Ser Leu Glu Leu  Gly Glu Asn Gly Ala  Ser Gly Lys 
    1325                 1330                 1335             


Gln Asn  Ser Glu Gln Ile Asp  Met Gln Asp Ile Lys  Ser Asp Leu 
    1340                 1345                 1350             


Arg Lys  Pro Leu Val Asn Gly  Ile Cys Asp Phe Asp  Lys Gly Asp 
    1355                 1360                 1365             


Gly Ser  His Leu Ser Lys Asn  Ile Pro Asn His Lys  Thr Ser Asn 
    1370                 1375                 1380             


His Val  Gly Asn Gly Glu Ile  Ser Pro Met Glu Pro  Gln Gly Thr 
    1385                 1390                 1395             


Leu Asp  Ile Thr Gln Gln Asp  Thr Ala Lys Gly Asp  Gln Leu Glu 
    1400                 1405                 1410             


Arg Ile  Ser Asn Gly Pro Val  Leu Thr Leu Gly Gly  Ser Ser Val 
    1415                 1420                 1425             


Ser Ser  Ile Gln Glu Ala Ser  Asn Ala Ala Thr Gln  Gln Phe Ser 
    1430                 1435                 1440             


Gly Thr  Asp Leu Leu Asn Gly  Pro Leu Ala Ser Ser  Leu Asn Ser 
    1445                 1450                 1455             


Asp Val  Pro Gln Gln Arg Pro  Ser Val Val Val Ser  Pro His Ser 
    1460                 1465                 1470             


Thr Thr  Ser Val Ile Gln Gly  His Gln Ile Ile Ala  Val Pro Asp 
    1475                 1480                 1485             


Ser Gly  Ser Lys Val Ser His  Ser Pro Ala Leu Ser  Ser Asp Val 
    1490                 1495                 1500             


Arg Ser  Thr Asn Gly Thr Ala  Glu Cys Lys Thr Val  Lys Arg Pro 
    1505                 1510                 1515             


Ala Glu  Asp Thr Asp Arg Glu  Thr Val Ala Gly Ile  Pro Asn Lys 
    1520                 1525                 1530             


Val Gly  Val Arg Ile Val Thr  Ile Ser Asp Pro Asn  Asn Ala Gly 
    1535                 1540                 1545             


Cys Ser  Ala Thr Met Val Ala  Val Pro Ala Gly Ala  Asp Pro Ser 
    1550                 1555                 1560             


Thr Val  Ala Lys Val Ala Ile  Glu Ser Ala Val Gln  Gln Lys Gln 
    1565                 1570                 1575             


Gln His  Pro Pro Thr Tyr Val  Gln Asn Val Val Pro  Gln Asn Thr 
    1580                 1585                 1590             


Pro Met  Pro Pro Ser Pro Ala  Val Gln Val Gln Gly  Gln Pro Asn 
    1595                 1600                 1605             


Ser Ser  Gln Pro Ser Pro Phe  Ser Gly Ser Ser Gln  Pro Gly Asp 
    1610                 1615                 1620             


Pro Met  Arg Lys Pro Gly Gln  Asn Phe Met Cys Leu  Trp Gln Ser 
    1625                 1630                 1635             


Cys Lys  Lys Trp Phe Gln Thr  Pro Ser Gln Val Phe  Tyr His Ala 
    1640                 1645                 1650             


Ala Thr  Glu His Gly Gly Lys  Asp Val Tyr Pro Gly  Gln Cys Leu 
    1655                 1660                 1665             


Trp Glu  Gly Cys Glu Pro Phe  Gln Arg Gln Arg Phe  Ser Phe Ile 
    1670                 1675                 1680             


Thr His  Leu Gln Asp Lys His  Cys Ser Lys Asp Ala  Leu Leu Ala 
    1685                 1690                 1695             


Gly Leu  Lys Gln Asp Glu Pro  Gly Gln Ala Gly Ser  Gln Lys Ser 
    1700                 1705                 1710             


Ser Thr  Lys Gln Pro Thr Val  Gly Gly Thr Ser Ser  Thr Pro Arg 
    1715                 1720                 1725             


Ala Gln  Lys Ala Ile Val Asn  His Pro Ser Ala Ala  Leu Met Ala 
    1730                 1735                 1740             


Leu Arg  Arg Gly Ser Arg Asn  Leu Val Phe Arg Asp  Phe Thr Asp 
    1745                 1750                 1755             


Glu Lys  Glu Gly Pro Ile Thr  Lys His Ile Arg Leu  Thr Ala Ala 
    1760                 1765                 1770             


Leu Ile  Leu Lys Asn Ile Gly  Lys Tyr Ser Glu Cys  Gly Arg Arg 
    1775                 1780                 1785             


Leu Leu  Lys Arg His Glu Asn  Asn Leu Ser Val Leu  Ala Ile Ser 
    1790                 1795                 1800             


Asn Met  Glu Ala Ser Ser Thr  Leu Ala Lys Cys Leu  Tyr Glu Leu 
    1805                 1810                 1815             


Asn Phe  Thr Val Gln Ser Lys  Glu Gln Glu Lys Asp  Ser Glu Met 
    1820                 1825                 1830             


Leu Gln  
    1835 


<210>  753
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARID3A__Homo_sapiens__NP_005215

<400>  753

Met Lys Leu Gln Ala Val Met Glu Thr Leu Leu Gln Arg Gln Gln Arg 
1               5                   10                  15      


Ala Arg Gln Glu Leu Glu Ala Arg Gln Gln Leu Pro Pro Asp Pro Pro 
            20                  25                  30          


Ala Ala Pro Pro Gly Arg Ala Arg Ala Ala Pro Asp Glu Asp Arg Glu 
        35                  40                  45              


Pro Glu Ser Ala Arg Met Gln Arg Ala Gln Met Ala Ala Leu Ala Ala 
    50                  55                  60                  


Met Arg Ala Ala Ala Ala Gly Leu Gly His Pro Ala Ser Pro Gly Gly 
65                  70                  75                  80  


Ser Glu Asp Gly Pro Pro Gly Ser Glu Glu Glu Asp Ala Ala Arg Glu 
                85                  90                  95      


Gly Thr Pro Gly Ser Pro Gly Arg Gly Arg Glu Gly Pro Gly Glu Glu 
            100                 105                 110         


His Phe Glu Asp Met Ala Ser Asp Glu Asp Met Lys Pro Lys Trp Glu 
        115                 120                 125             


Glu Glu Glu Met Glu Glu Asp Leu Gly Glu Asp Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Asp Tyr Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Gly Leu Gly 
145                 150                 155                 160 


Pro Pro Gly Pro Ala Ser Leu Gly Thr Thr Ala Leu Phe Pro Arg Lys 
                165                 170                 175     


Ala Gln Pro Pro Gln Ala Phe Arg Gly Asp Gly Val Pro Arg Val Leu 
            180                 185                 190         


Gly Gly Gln Glu Arg Pro Gly Pro Gly Pro Ala His Pro Gly Gly Ala 
        195                 200                 205             


Ala His Val Ala Pro Gln Leu Gln Pro Pro Asp His Gly Asp Trp Thr 
    210                 215                 220                 


Tyr Glu Glu Gln Phe Lys Gln Leu Tyr Glu Leu Asp Gly Asp Pro Lys 
225                 230                 235                 240 


Arg Lys Glu Phe Leu Asp Asp Leu Phe Ser Phe Met Gln Lys Arg Gly 
                245                 250                 255     


Thr Pro Val Asn Arg Ile Pro Ile Met Ala Lys Gln Val Leu Asp Leu 
            260                 265                 270         


Phe Met Leu Tyr Val Leu Val Thr Glu Lys Gly Gly Leu Val Glu Val 
        275                 280                 285             


Ile Asn Lys Lys Leu Trp Arg Glu Ile Thr Lys Gly Leu Asn Leu Pro 
    290                 295                 300                 


Thr Ser Ile Thr Ser Ala Ala Phe Thr Leu Arg Thr Gln Tyr Met Lys 
305                 310                 315                 320 


Tyr Leu Tyr Pro Tyr Glu Cys Glu Lys Arg Gly Leu Ser Asn Pro Asn 
                325                 330                 335     


Glu Leu Gln Ala Ala Ile Asp Ser Asn Arg Arg Glu Gly Arg Arg Gln 
            340                 345                 350         


Ser Phe Gly Gly Ser Leu Phe Ala Tyr Ser Pro Gly Gly Ala His Gly 
        355                 360                 365             


Met Leu Ser Ser Pro Lys Leu Pro Val Ser Ser Leu Gly Leu Ala Ala 
    370                 375                 380                 


Ser Thr Asn Gly Ser Ser Ile Thr Pro Ala Pro Lys Ile Lys Lys Glu 
385                 390                 395                 400 


Glu Asp Ser Ala Ile Pro Ile Thr Val Pro Gly Arg Leu Pro Val Ser 
                405                 410                 415     


Leu Ala Gly His Pro Val Val Ala Ala Gln Ala Ala Ala Val Gln Ala 
            420                 425                 430         


Ala Ala Ala Gln Ala Ala Val Ala Ala Gln Ala Ala Ala Leu Glu Gln 
        435                 440                 445             


Leu Arg Glu Lys Leu Glu Ser Ala Glu Pro Pro Glu Lys Lys Met Ala 
    450                 455                 460                 


Leu Val Ala Asp Glu Gln Gln Arg Leu Met Gln Arg Ala Leu Gln Gln 
465                 470                 475                 480 


Asn Phe Leu Ala Met Ala Ala Gln Leu Pro Met Ser Ile Arg Ile Asn 
                485                 490                 495     


Ser Gln Ala Ser Glu Ser Arg Gln Asp Ser Ala Val Asn Leu Thr Gly 
            500                 505                 510         


Thr Asn Gly Ser Asn Ser Ile Ser Met Ser Val Glu Ile Asn Gly Ile 
        515                 520                 525             


Met Tyr Thr Gly Val Leu Phe Ala Gln Pro Pro Ala Pro Thr Pro Thr 
    530                 535                 540                 


Ser Ala Pro Asn Lys Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Asn 
545                 550                 555                 560 


Ala Gly Gly Arg Gly Gly Asn Thr Gly Thr Ser Gly Gly Gln Ala Gly 
                565                 570                 575     


Pro Ala Gly Leu Ser Thr Pro Ser Thr Ser Thr Ser Asn Asn Ser Leu 
            580                 585                 590         


Pro 
    


<210>  754
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARID3B__Homo_sapiens__NP_006456

<400>  754

Met Glu Pro Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys 
1               5                   10                  15      


Gln Pro His Leu Ala Pro Leu Gln Met Asp Ala Arg Glu Lys Gln Gly 
            20                  25                  30          


Gln Gln Met Arg Glu Ala Gln Phe Leu Tyr Ala Gln Lys Leu Val Thr 
        35                  40                  45              


Gln Pro Thr Leu Leu Ser Ala Thr Ala Gly Arg Pro Ser Gly Ser Thr 
    50                  55                  60                  


Pro Leu Gly Pro Leu Ala Arg Val Pro Pro Thr Ala Ala Val Ala Gln 
65                  70                  75                  80  


Val Phe Glu Arg Gly Asn Met Asn Ser Glu Pro Glu Glu Glu Asp Gly 
                85                  90                  95      


Gly Leu Glu Asp Glu Asp Gly Asp Asp Glu Val Ala Glu Val Ala Glu 
            100                 105                 110         


Lys Glu Thr Gln Ala Ala Ser Lys Tyr Phe His Val Gln Lys Val Ala 
        115                 120                 125             


Arg Gln Asp Pro Arg Val Ala Pro Met Ser Asn Leu Leu Pro Ala Pro 
    130                 135                 140                 


Gly Leu Pro Pro His Gly Gln Gln Ala Lys Glu Asp His Thr Lys Asp 
145                 150                 155                 160 


Ala Ser Lys Ala Ser Pro Ser Val Ser Thr Ala Gly Gln Pro Asn Trp 
                165                 170                 175     


Asn Leu Asp Glu Gln Leu Lys Gln Asn Gly Gly Leu Ala Trp Ser Asp 
            180                 185                 190         


Asp Ala Asp Gly Gly Arg Gly Arg Glu Ile Ser Arg Asp Phe Ala Lys 
        195                 200                 205             


Leu Tyr Glu Leu Asp Gly Asp Pro Glu Arg Lys Glu Phe Leu Asp Asp 
    210                 215                 220                 


Leu Phe Val Phe Met Gln Lys Arg Gly Thr Pro Ile Asn Arg Ile Pro 
225                 230                 235                 240 


Ile Met Ala Lys Gln Ile Leu Asp Leu Tyr Met Leu Tyr Lys Leu Val 
                245                 250                 255     


Thr Glu Lys Gly Gly Leu Val Glu Ile Ile Asn Lys Lys Ile Trp Arg 
            260                 265                 270         


Glu Ile Thr Lys Gly Leu Asn Leu Pro Thr Ser Ile Thr Ser Ala Ala 
        275                 280                 285             


Phe Thr Leu Arg Thr Gln Tyr Met Lys Tyr Leu Tyr Ala Tyr Glu Cys 
    290                 295                 300                 


Glu Lys Lys Ala Leu Ser Ser Pro Ala Glu Leu Gln Ala Ala Ile Asp 
305                 310                 315                 320 


Gly Asn Arg Arg Glu Gly Arg Arg Pro Ser Tyr Ser Ser Ser Leu Phe 
                325                 330                 335     


Gly Tyr Ser Pro Ala Ala Ala Thr Ala Ala Ala Ala Ala Gly Ala Pro 
            340                 345                 350         


Ala Leu Leu Ser Pro Pro Lys Ile Arg Phe Pro Ile Leu Gly Leu Gly 
        355                 360                 365             


Ser Ser Ser Gly Thr Asn Thr Ser Ser Pro Arg Ile Ser Pro Ala Thr 
    370                 375                 380                 


Thr Leu Arg Lys Gly Asp Gly Ala Pro Val Thr Thr Val Pro Val Pro 
385                 390                 395                 400 


Asn Arg Leu Ala Val Pro Val Thr Leu Ala Ser Gln Gln Ala Gly Thr 
                405                 410                 415     


Arg Thr Ala Ala Leu Glu Gln Leu Arg Glu Arg Leu Glu Ser Gly Glu 
            420                 425                 430         


Pro Ala Glu Lys Lys Ala Ser Arg Leu Ser Glu Glu Glu Gln Arg Leu 
        435                 440                 445             


Val Gln Gln Ala Phe Gln Arg Asn Phe Phe Ser Met Ala Arg Gln Leu 
    450                 455                 460                 


Pro Met Lys Ile Arg Ile Asn Gly Arg Glu Asp Arg Ala Glu Ala Ser 
465                 470                 475                 480 


Ala Ala Ala Leu Asn Leu Thr Thr Ser Ser Ile Gly Ser Ile Asn Met 
                485                 490                 495     


Ser Val Asp Ile Asp Gly Thr Thr Tyr Ala Gly Val Leu Phe Ala Gln 
            500                 505                 510         


Lys Pro Val Val His Leu Ile Thr Gly Ser Ala Pro Gln Ser Leu Gly 
        515                 520                 525             


Ser Ser Ala Ser Ser Ser Ser Ser Ser His Cys Ser Pro Ser Pro Thr 
    530                 535                 540                 


Ser Ser Arg Gly Thr Pro Ser Ala Glu Pro Ser Thr Ser Trp Ser Leu 
545                 550                 555                 560 


<210>  755
<211>  1257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARID4A__Homo_sapiens__NP_002883

<400>  755

Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Val 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Leu Leu Lys Gln Asp Asn Thr Thr 
        35                  40                  45              


Gln Leu Val Gln Asp Asp Gln Val Lys Gly Pro Leu Arg Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Thr Arg Thr Ser Asp Gly Ser Phe Gln Glu Ala Ile Ile 
65                  70                  75                  80  


Ser Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Arg Thr Leu Arg Arg Thr Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Ala Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Ser Leu Pro Val Thr Glu Asp Glu Lys Glu Glu Glu Ser Ser 
145                 150                 155                 160 


Glu Glu Glu Asp Glu Asp Lys Arg Arg Leu Asn Asp Glu Leu Leu Gly 
                165                 170                 175     


Lys Val Val Ser Val Val Ser Ala Thr Glu Arg Thr Glu Trp Tyr Pro 
            180                 185                 190         


Ala Leu Val Ile Ser Pro Ser Cys Asn Asp Asp Ile Thr Val Lys Lys 
        195                 200                 205             


Asp Gln Cys Leu Val Arg Ser Phe Ile Asp Ser Lys Phe Tyr Ser Ile 
    210                 215                 220                 


Ala Arg Lys Asp Ile Lys Glu Val Asp Ile Leu Asn Leu Pro Glu Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Lys Pro Gly Leu Gln Lys Ala Ser Ile Phe Leu Lys 
                245                 250                 255     


Thr Arg Val Val Pro Asp Asn Trp Lys Met Asp Ile Ser Glu Ile Leu 
            260                 265                 270         


Glu Ser Ser Ser Ser Asp Asp Glu Asp Gly Pro Ala Glu Glu Asn Asp 
        275                 280                 285             


Glu Glu Lys Glu Lys Glu Ala Lys Lys Thr Glu Glu Glu Val Pro Glu 
    290                 295                 300                 


Glu Glu Leu Asp Pro Glu Glu Arg Asp Asn Phe Leu Gln Gln Leu Tyr 
305                 310                 315                 320 


Lys Phe Met Glu Asp Arg Gly Thr Pro Ile Asn Lys Pro Pro Val Leu 
                325                 330                 335     


Gly Tyr Lys Asp Leu Asn Leu Phe Lys Leu Phe Arg Leu Val Tyr His 
            340                 345                 350         


Gln Gly Gly Cys Asp Asn Ile Asp Ser Gly Ala Val Trp Lys Gln Ile 
        355                 360                 365             


Tyr Met Asp Leu Gly Ile Pro Ile Leu Asn Ser Ala Ala Ser Tyr Asn 
    370                 375                 380                 


Val Lys Thr Ala Tyr Arg Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys 
385                 390                 395                 400 


Arg Ser Ala Asn Ile Gln Phe Arg Thr Val His His His Glu Pro Lys 
                405                 410                 415     


Val Lys Glu Glu Lys Lys Asp Leu Glu Glu Ser Met Glu Glu Ala Leu 
            420                 425                 430         


Lys Leu Asp Gln Glu Met Pro Leu Thr Glu Val Lys Ser Glu Pro Glu 
        435                 440                 445             


Glu Asn Ile Asp Ser Asn Ser Glu Ser Glu Arg Glu Glu Ile Glu Leu 
    450                 455                 460                 


Lys Ser Pro Arg Gly Arg Arg Arg Ile Ala Arg Asp Val Asn Ser Ile 
465                 470                 475                 480 


Lys Lys Glu Ile Glu Glu Glu Lys Thr Glu Asp Lys Leu Lys Asp Asn 
                485                 490                 495     


Asp Thr Glu Asn Lys Asp Val Asp Asp Asp Tyr Glu Thr Ala Glu Lys 
            500                 505                 510         


Lys Glu Asn Glu Leu Leu Leu Gly Arg Lys Asn Thr Pro Lys Gln Lys 
        515                 520                 525             


Glu Lys Lys Ile Lys Lys Gln Glu Asp Ser Asp Lys Asp Ser Asp Glu 
    530                 535                 540                 


Glu Glu Glu Lys Ser Gln Glu Arg Glu Glu Thr Glu Ser Lys Cys Asp 
545                 550                 555                 560 


Ser Glu Gly Glu Glu Asp Glu Glu Asp Met Glu Pro Cys Leu Thr Gly 
                565                 570                 575     


Thr Lys Val Lys Val Lys Tyr Gly Arg Gly Lys Thr Gln Lys Ile Tyr 
            580                 585                 590         


Glu Ala Ser Ile Lys Ser Thr Glu Ile Asp Asp Gly Glu Val Leu Tyr 
        595                 600                 605             


Leu Val His Tyr Tyr Gly Trp Asn Val Arg Tyr Asp Glu Trp Val Lys 
    610                 615                 620                 


Ala Asp Arg Ile Ile Trp Pro Leu Asp Lys Gly Gly Pro Lys Lys Lys 
625                 630                 635                 640 


Gln Lys Lys Lys Ala Lys Asn Lys Glu Asp Ser Glu Lys Asp Glu Lys 
                645                 650                 655     


Arg Asp Glu Glu Arg Gln Lys Ser Lys Arg Gly Arg Pro Pro Leu Lys 
            660                 665                 670         


Ser Thr Leu Ser Ser Asn Met Pro Tyr Gly Leu Ser Lys Thr Ala Asn 
        675                 680                 685             


Ser Glu Gly Lys Ser Asp Ser Cys Ser Ser Asp Ser Glu Thr Glu Asp 
    690                 695                 700                 


Ala Leu Glu Lys Asn Leu Ile Asn Glu Glu Leu Ser Leu Lys Asp Glu 
705                 710                 715                 720 


Leu Glu Lys Asn Glu Asn Leu Asn Asp Asp Lys Leu Asp Glu Glu Asn 
                725                 730                 735     


Pro Lys Ile Ser Ala His Ile Leu Lys Glu Asn Asp Arg Thr Gln Met 
            740                 745                 750         


Gln Pro Leu Glu Thr Leu Lys Leu Glu Val Gly Glu Asn Glu Gln Ile 
        755                 760                 765             


Val Gln Ile Phe Gly Asn Lys Met Glu Lys Thr Glu Glu Val Lys Lys 
    770                 775                 780                 


Glu Ala Glu Lys Ser Pro Lys Gly Lys Gly Arg Arg Ser Lys Thr Lys 
785                 790                 795                 800 


Asp Leu Ser Leu Glu Ile Ile Lys Ile Ser Ser Phe Gly Gln Asn Glu 
                805                 810                 815     


Ala Gly Ser Glu Pro His Ile Glu Ala His Ser Leu Glu Leu Ser Ser 
            820                 825                 830         


Leu Asp Asn Lys Asn Phe Ser Ser Ala Thr Glu Asp Glu Ile Asp Gln 
        835                 840                 845             


Cys Val Lys Glu Lys Lys Leu Lys Arg Lys Ile Leu Gly Gln Ser Ser 
    850                 855                 860                 


Pro Glu Lys Lys Ile Arg Ile Glu Asn Gly Met Glu Met Thr Asn Thr 
865                 870                 875                 880 


Val Ser Gln Glu Arg Thr Ser Asp Cys Ile Gly Ser Glu Gly Met Lys 
                885                 890                 895     


Asn Leu Asn Phe Glu Gln His Phe Glu Arg Glu Asn Glu Gly Met Pro 
            900                 905                 910         


Ser Leu Ile Ala Glu Ser Asn Gln Cys Ile Gln Gln Leu Thr Ser Glu 
        915                 920                 925             


Arg Phe Asp Ser Pro Ala Glu Glu Thr Val Asn Ile Pro Leu Lys Glu 
    930                 935                 940                 


Asp Glu Asp Ala Met Pro Leu Ile Gly Pro Glu Thr Leu Val Cys His 
945                 950                 955                 960 


Glu Val Asp Leu Asp Asp Leu Asp Glu Lys Asp Lys Thr Ser Ile Glu 
                965                 970                 975     


Asp Val Ala Val Glu Ser Ser Glu Ser Asn Ser Leu Val Ser Ile Pro 
            980                 985                 990         


Pro Ala Leu Pro Pro Val Val Gln  His Asn Phe Ser Val  Ala Ser Pro 
        995                 1000                 1005             


Leu Thr  Leu Ser Gln Asp Glu  Ser Arg Ser Val Lys  Ser Glu Ser 
    1010                 1015                 1020             


Asp Ile  Thr Ile Glu Val Asp  Ser Ile Ala Glu Glu  Ser Gln Glu 
    1025                 1030                 1035             


Gly Leu  Cys Glu Arg Glu Ser  Ala Asn Gly Phe Glu  Thr Asn Val 
    1040                 1045                 1050             


Ala Ser  Gly Thr Cys Ser Ile  Ile Val Gln Glu Arg  Glu Ser Arg 
    1055                 1060                 1065             


Glu Lys  Gly Gln Lys Arg Pro  Ser Asp Gly Asn Ser  Gly Leu Met 
    1070                 1075                 1080             


Ala Lys  Lys Gln Lys Arg Thr  Pro Lys Arg Thr Ser  Ala Ala Ala 
    1085                 1090                 1095             


Lys Asn  Glu Lys Asn Gly Thr  Gly Gln Ser Ser Asp  Ser Glu Asp 
    1100                 1105                 1110             


Leu Pro  Val Leu Asp Asn Ser  Ser Lys Cys Thr Pro  Val Lys His 
    1115                 1120                 1125             


Leu Asn  Val Ser Lys Pro Gln  Lys Leu Ala Arg Ser  Pro Ala Arg 
    1130                 1135                 1140             


Ile Ser  Pro His Ile Lys Asp  Gly Glu Lys Asp Lys  His Arg Glu 
    1145                 1150                 1155             


Lys His  Pro Asn Ser Ser Pro  Arg Thr Tyr Lys Trp  Ser Phe Gln 
    1160                 1165                 1170             


Leu Asn  Glu Leu Asp Asn Met  Asn Ser Thr Glu Arg  Ile Ser Phe 
    1175                 1180                 1185             


Leu Gln  Glu Lys Leu Gln Glu  Ile Arg Lys Tyr Tyr  Met Ser Leu 
    1190                 1195                 1200             


Lys Ser  Glu Val Ala Thr Ile  Asp Arg Arg Arg Lys  Arg Leu Lys 
    1205                 1210                 1215             


Lys Lys  Asp Arg Glu Val Ser  His Ala Gly Ala Ser  Met Ser Ser 
    1220                 1225                 1230             


Ala Ser  Ser Asp Thr Gly Met  Ser Pro Ser Ser Ser  Ser Pro Pro 
    1235                 1240                 1245             


Gln Asn  Val Leu Ala Val Glu  Cys Arg 
    1250                 1255         


<210>  756
<211>  1312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARID4B__Homo_sapiens__NP_057458

<400>  756

Met Lys Ala Leu Asp Glu Pro Pro Tyr Leu Thr Val Gly Thr Asp Val 
1               5                   10                  15      


Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Ala 
            20                  25                  30          


Lys Arg Leu Val Lys Val Lys Val Thr Phe Arg His Asp Ser Ser Thr 
        35                  40                  45              


Val Glu Val Gln Asp Asp His Ile Lys Gly Pro Leu Lys Val Gly Ala 
    50                  55                  60                  


Ile Val Glu Val Lys Asn Leu Asp Gly Ala Tyr Gln Glu Ala Val Ile 
65                  70                  75                  80  


Asn Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly 
                85                  90                  95      


Asp Glu Lys Thr Leu Arg Arg Ser Ser Leu Cys Leu Lys Gly Glu Arg 
            100                 105                 110         


His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro 
        115                 120                 125             


Glu His Phe Gly Thr Pro Val Ile Gly Lys Lys Thr Asn Arg Gly Arg 
    130                 135                 140                 


Arg Ser Asn His Ile Pro Glu Glu Glu Ser Ser Ser Ser Ser Ser Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Asp Arg Lys Gln Ile Asp Glu Leu Leu Gly Lys Val 
                165                 170                 175     


Val Cys Val Asp Tyr Ile Ser Leu Asp Lys Lys Lys Ala Leu Trp Phe 
            180                 185                 190         


Pro Ala Leu Val Val Cys Pro Asp Cys Ser Asp Glu Ile Ala Val Lys 
        195                 200                 205             


Lys Asp Asn Ile Leu Val Arg Ser Phe Lys Asp Gly Lys Phe Thr Ser 
    210                 215                 220                 


Val Pro Arg Lys Asp Val His Glu Ile Thr Ser Asp Thr Ala Pro Lys 
225                 230                 235                 240 


Pro Asp Ala Val Leu Lys Gln Ala Phe Glu Gln Ala Leu Glu Phe His 
                245                 250                 255     


Lys Ser Arg Thr Ile Pro Ala Asn Trp Lys Thr Glu Leu Lys Glu Asp 
            260                 265                 270         


Ser Ser Ser Ser Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu 
        275                 280                 285             


Lys Glu Lys Glu Asp Asn Ser Ser Glu Glu Glu Glu Glu Ile Glu Pro 
    290                 295                 300                 


Phe Pro Glu Glu Arg Glu Asn Phe Leu Gln Gln Leu Tyr Lys Phe Met 
305                 310                 315                 320 


Glu Asp Arg Gly Thr Pro Ile Asn Lys Arg Pro Val Leu Gly Tyr Arg 
                325                 330                 335     


Asn Leu Asn Leu Phe Lys Leu Phe Arg Leu Val His Lys Leu Gly Gly 
            340                 345                 350         


Phe Asp Asn Ile Glu Ser Gly Ala Val Trp Lys Gln Val Tyr Gln Asp 
        355                 360                 365             


Leu Gly Ile Pro Val Leu Asn Ser Ala Ala Gly Tyr Asn Val Lys Cys 
    370                 375                 380                 


Ala Tyr Lys Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys Arg Ser Ala 
385                 390                 395                 400 


Asn Ile Glu Phe Gln Met Ala Leu Pro Glu Lys Val Val Asn Lys Gln 
                405                 410                 415     


Cys Lys Glu Cys Glu Asn Val Lys Glu Ile Lys Val Lys Glu Glu Asn 
            420                 425                 430         


Glu Thr Glu Ile Lys Glu Ile Lys Met Glu Glu Glu Arg Asn Ile Ile 
        435                 440                 445             


Pro Arg Glu Glu Lys Pro Ile Glu Asp Glu Ile Glu Arg Lys Glu Asn 
    450                 455                 460                 


Ile Lys Pro Ser Leu Gly Ser Lys Lys Asn Leu Leu Glu Ser Ile Pro 
465                 470                 475                 480 


Thr His Ser Asp Gln Glu Lys Glu Val Asn Ile Lys Lys Pro Glu Asp 
                485                 490                 495     


Asn Glu Asn Leu Asp Asp Lys Asp Asp Asp Thr Thr Arg Val Asp Glu 
            500                 505                 510         


Ser Leu Asn Ile Lys Val Glu Ala Glu Glu Glu Lys Ala Lys Ser Gly 
        515                 520                 525             


Asp Glu Thr Asn Lys Glu Glu Asp Glu Asp Asp Glu Glu Ala Glu Glu 
    530                 535                 540                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asp Asp Asp Asp Asn 
545                 550                 555                 560 


Asn Glu Glu Glu Glu Phe Glu Cys Tyr Pro Pro Gly Met Lys Val Gln 
                565                 570                 575     


Val Arg Tyr Gly Arg Gly Lys Asn Gln Lys Met Tyr Glu Ala Ser Ile 
            580                 585                 590         


Lys Asp Ser Asp Val Glu Gly Gly Glu Val Leu Tyr Leu Val His Tyr 
        595                 600                 605             


Cys Gly Trp Asn Val Arg Tyr Asp Glu Trp Ile Lys Ala Asp Lys Ile 
    610                 615                 620                 


Val Arg Pro Ala Asp Lys Asn Val Pro Lys Ile Lys His Arg Lys Lys 
625                 630                 635                 640 


Ile Lys Asn Lys Leu Asp Lys Glu Lys Asp Lys Asp Glu Lys Tyr Ser 
                645                 650                 655     


Pro Lys Asn Cys Lys Leu Arg Arg Leu Ser Lys Pro Pro Phe Gln Thr 
            660                 665                 670         


Asn Pro Ser Pro Glu Met Val Ser Lys Leu Asp Leu Thr Asp Ala Lys 
        675                 680                 685             


Asn Ser Asp Thr Ala His Ile Lys Ser Ile Glu Ile Thr Ser Ile Leu 
    690                 695                 700                 


Asn Gly Leu Gln Ala Ser Glu Ser Ser Ala Glu Asp Ser Glu Gln Glu 
705                 710                 715                 720 


Asp Glu Arg Gly Ala Gln Asp Met Asp Asn Asn Gly Lys Glu Glu Ser 
                725                 730                 735     


Lys Ile Asp His Leu Thr Asn Asn Arg Asn Asp Leu Ile Ser Lys Glu 
            740                 745                 750         


Glu Gln Asn Ser Ser Ser Leu Leu Glu Glu Asn Lys Val His Ala Asp 
        755                 760                 765             


Leu Val Ile Ser Lys Pro Val Ser Lys Ser Pro Glu Arg Leu Arg Lys 
    770                 775                 780                 


Asp Ile Glu Val Leu Ser Glu Asp Thr Asp Tyr Glu Glu Asp Glu Val 
785                 790                 795                 800 


Thr Lys Lys Arg Lys Asp Val Lys Lys Asp Thr Thr Asp Lys Ser Ser 
                805                 810                 815     


Lys Pro Gln Ile Lys Arg Gly Lys Arg Arg Tyr Cys Asn Thr Glu Glu 
            820                 825                 830         


Cys Leu Lys Thr Gly Ser Pro Gly Lys Lys Glu Glu Lys Ala Lys Asn 
        835                 840                 845             


Lys Glu Ser Leu Cys Met Glu Asn Ser Ser Asn Ser Ser Ser Asp Glu 
    850                 855                 860                 


Asp Glu Glu Glu Thr Lys Ala Lys Met Thr Pro Thr Lys Lys Tyr Asn 
865                 870                 875                 880 


Gly Leu Glu Glu Lys Arg Lys Ser Leu Arg Thr Thr Gly Phe Tyr Ser 
                885                 890                 895     


Gly Phe Ser Glu Val Ala Glu Lys Arg Ile Lys Leu Leu Asn Asn Ser 
            900                 905                 910         


Asp Glu Arg Leu Gln Asn Ser Arg Ala Lys Asp Arg Lys Asp Val Trp 
        915                 920                 925             


Ser Ser Ile Gln Gly Gln Trp Pro Lys Lys Thr Leu Lys Glu Leu Phe 
    930                 935                 940                 


Ser Asp Ser Asp Thr Glu Ala Ala Ala Ser Pro Pro His Pro Ala Pro 
945                 950                 955                 960 


Glu Glu Gly Val Ala Glu Glu Ser Leu Gln Thr Val Ala Glu Glu Glu 
                965                 970                 975     


Ser Cys Ser Pro Ser Val Glu Leu Glu Lys Pro Pro Pro Val Asn Val 
            980                 985                 990         


Asp Ser Lys Pro Ile Glu Glu Lys  Thr Val Glu Val Asn  Asp Arg Lys 
        995                 1000                 1005             


Ala Glu  Phe Pro Ser Ser Gly  Ser Asn Ser Val Leu  Asn Thr Pro 
    1010                 1015                 1020             


Pro Thr  Thr Pro Glu Ser Pro  Ser Ser Val Thr Val  Thr Glu Gly 
    1025                 1030                 1035             


Ser Arg  Gln Gln Ser Ser Val  Thr Val Ser Glu Pro  Leu Ala Pro 
    1040                 1045                 1050             


Asn Gln  Glu Glu Val Arg Ser  Ile Lys Ser Glu Thr  Asp Ser Thr 
    1055                 1060                 1065             


Ile Glu  Val Asp Ser Val Ala  Gly Glu Leu Gln Asp  Leu Gln Ser 
    1070                 1075                 1080             


Glu Gly  Asn Ser Ser Pro Ala  Gly Phe Asp Ala Ser  Val Ser Ser 
    1085                 1090                 1095             


Ser Ser  Ser Asn Gln Pro Glu  Pro Glu His Pro Glu  Lys Ala Cys 
    1100                 1105                 1110             


Thr Gly  Gln Lys Arg Val Lys  Asp Ala Gln Gly Gly  Gly Ser Ser 
    1115                 1120                 1125             


Ser Lys  Lys Gln Lys Arg Ser  His Lys Ala Thr Val  Val Asn Asn 
    1130                 1135                 1140             


Lys Lys  Lys Gly Lys Gly Thr  Asn Ser Ser Asp Ser  Glu Glu Leu 
    1145                 1150                 1155             


Ser Ala  Gly Glu Ser Ile Thr  Lys Ser Gln Pro Val  Lys Ser Val 
    1160                 1165                 1170             


Ser Thr  Gly Met Lys Ser His  Ser Thr Lys Ser Pro  Ala Arg Thr 
    1175                 1180                 1185             


Gln Ser  Pro Gly Lys Cys Gly  Lys Asn Gly Asp Lys  Asp Pro Asp 
    1190                 1195                 1200             


Leu Lys  Glu Pro Ser Asn Arg  Leu Pro Lys Val Tyr  Lys Trp Ser 
    1205                 1210                 1215             


Phe Gln  Met Ser Asp Leu Glu  Asn Met Thr Ser Ala  Glu Arg Ile 
    1220                 1225                 1230             


Thr Ile  Leu Gln Glu Lys Leu  Gln Glu Ile Arg Lys  His Tyr Leu 
    1235                 1240                 1245             


Ser Leu  Lys Ser Glu Val Ala  Ser Ile Asp Arg Arg  Arg Lys Arg 
    1250                 1255                 1260             


Leu Lys  Lys Lys Glu Arg Glu  Ser Ala Ala Thr Ser  Ser Ser Ser 
    1265                 1270                 1275             


Ser Ser  Pro Ser Ser Ser Ser  Ile Thr Ala Ala Val  Met Leu Thr 
    1280                 1285                 1290             


Leu Ala  Glu Pro Ser Met Ser  Ser Ala Ser Gln Asn  Gly Met Ser 
    1295                 1300                 1305             


Val Glu  Cys Arg 
    1310         


<210>  757
<211>  945
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARID5B__Homo_sapiens__NP_001231567

<400>  757

Met Ala Pro Asn Leu Lys Gly Arg Pro Arg Lys Lys Lys Pro Cys Pro 
1               5                   10                  15      


Gln Arg Arg Asp Ser Phe Ser Gly Val Lys Asp Ser Asn Asn Asn Ser 
            20                  25                  30          


Asp Gly Lys Ala Val Ala Lys Val Lys Cys Glu Ala Arg Ser Ala Leu 
        35                  40                  45              


Thr Lys Pro Lys Asn Asn His Asn Cys Lys Lys Val Ser Asn Glu Glu 
    50                  55                  60                  


Lys Pro Lys Val Ala Ile Gly Glu Glu Cys Arg Ala Asp Glu Gln Ala 
65                  70                  75                  80  


Phe Leu Val Ala Leu Tyr Lys Tyr Met Lys Glu Arg Lys Thr Pro Ile 
                85                  90                  95      


Glu Arg Ile Pro Tyr Leu Gly Phe Lys Gln Ile Asn Leu Trp Thr Met 
            100                 105                 110         


Phe Gln Ala Ala Gln Lys Leu Gly Gly Tyr Glu Thr Ile Thr Ala Arg 
        115                 120                 125             


Arg Gln Trp Lys His Ile Tyr Asp Glu Leu Gly Gly Asn Pro Gly Ser 
    130                 135                 140                 


Thr Ser Ala Ala Thr Cys Thr Arg Arg His Tyr Glu Arg Leu Ile Leu 
145                 150                 155                 160 


Pro Tyr Glu Arg Phe Ile Lys Gly Glu Glu Asp Lys Pro Leu Pro Pro 
                165                 170                 175     


Ile Lys Pro Arg Lys Gln Glu Asn Ser Ser Gln Glu Asn Glu Asn Lys 
            180                 185                 190         


Thr Lys Val Ser Gly Thr Lys Arg Ile Lys His Glu Ile Pro Lys Ser 
        195                 200                 205             


Lys Lys Glu Lys Glu Asn Ala Pro Lys Pro Gln Asp Ala Ala Glu Val 
    210                 215                 220                 


Ser Ser Glu Gln Glu Lys Glu Gln Glu Thr Leu Ile Ser Gln Lys Ser 
225                 230                 235                 240 


Ile Pro Glu Pro Leu Pro Ala Ala Asp Met Lys Lys Lys Ile Glu Gly 
                245                 250                 255     


Tyr Gln Glu Phe Ser Ala Lys Pro Leu Ala Ser Arg Val Asp Pro Glu 
            260                 265                 270         


Lys Asp Asn Glu Thr Asp Gln Gly Ser Asn Ser Glu Lys Val Ala Glu 
        275                 280                 285             


Glu Ala Gly Glu Lys Gly Pro Thr Pro Pro Leu Pro Ser Ala Pro Leu 
    290                 295                 300                 


Ala Pro Glu Lys Asp Ser Ala Leu Val Pro Gly Ala Ser Lys Gln Pro 
305                 310                 315                 320 


Leu Thr Ser Pro Ser Ala Leu Val Asp Ser Lys Gln Glu Ser Lys Leu 
                325                 330                 335     


Cys Cys Phe Thr Glu Ser Pro Glu Ser Glu Pro Gln Glu Ala Ser Phe 
            340                 345                 350         


Pro Ser Phe Pro Thr Thr Gln Pro Pro Leu Ala Asn Gln Asn Glu Thr 
        355                 360                 365             


Glu Asp Asp Lys Leu Pro Ala Met Ala Asp Tyr Ile Ala Asn Cys Thr 
    370                 375                 380                 


Val Lys Val Asp Gln Leu Gly Ser Asp Asp Ile His Asn Ala Leu Lys 
385                 390                 395                 400 


Gln Thr Pro Lys Val Leu Val Val Gln Ser Phe Asp Met Phe Lys Asp 
                405                 410                 415     


Lys Asp Leu Thr Gly Pro Met Asn Glu Asn His Gly Leu Asn Tyr Thr 
            420                 425                 430         


Pro Leu Leu Tyr Ser Arg Gly Asn Pro Gly Ile Met Ser Pro Leu Ala 
        435                 440                 445             


Lys Lys Lys Leu Leu Ser Gln Val Ser Gly Ala Ser Leu Ser Ser Ser 
    450                 455                 460                 


Tyr Pro Tyr Gly Ser Pro Pro Pro Leu Ile Ser Lys Lys Lys Leu Ile 
465                 470                 475                 480 


Ala Arg Asp Asp Leu Cys Ser Ser Leu Ser Gln Thr His His Gly Gln 
                485                 490                 495     


Ser Thr Asp His Met Ala Val Ser Arg Pro Ser Val Ile Gln His Val 
            500                 505                 510         


Gln Ser Phe Arg Ser Lys Pro Ser Glu Glu Arg Lys Thr Ile Asn Asp 
        515                 520                 525             


Ile Phe Lys His Glu Lys Leu Ser Arg Ser Asp Pro His Arg Cys Ser 
    530                 535                 540                 


Phe Ser Lys His His Leu Asn Pro Leu Ala Asp Ser Tyr Val Leu Lys 
545                 550                 555                 560 


Gln Glu Ile Gln Glu Gly Lys Asp Lys Leu Leu Glu Lys Arg Ala Leu 
                565                 570                 575     


Pro His Ser His Met Pro Ser Phe Leu Ala Asp Phe Tyr Ser Ser Pro 
            580                 585                 590         


His Leu His Ser Leu Tyr Arg His Thr Glu His His Leu His Asn Glu 
        595                 600                 605             


Gln Thr Ser Lys Tyr Pro Ser Arg Asp Met Tyr Arg Glu Ser Glu Asn 
    610                 615                 620                 


Ser Ser Phe Pro Ser His Arg His Gln Glu Lys Leu His Val Asn Tyr 
625                 630                 635                 640 


Leu Thr Ser Leu His Leu Gln Asp Lys Lys Ser Ala Ala Ala Glu Ala 
                645                 650                 655     


Pro Thr Asp Asp Gln Pro Thr Asp Leu Ser Leu Pro Lys Asn Pro His 
            660                 665                 670         


Lys Pro Thr Gly Lys Val Leu Gly Leu Ala His Ser Thr Thr Gly Pro 
        675                 680                 685             


Gln Glu Ser Lys Gly Ile Ser Gln Phe Gln Val Leu Gly Ser Gln Ser 
    690                 695                 700                 


Arg Asp Cys His Pro Lys Ala Cys Arg Val Ser Pro Met Thr Met Ser 
705                 710                 715                 720 


Gly Pro Lys Lys Tyr Pro Glu Ser Leu Ser Arg Ser Gly Lys Pro His 
                725                 730                 735     


His Val Arg Leu Glu Asn Phe Arg Lys Met Glu Gly Met Val His Pro 
            740                 745                 750         


Ile Leu His Arg Lys Met Ser Pro Gln Asn Ile Gly Ala Ala Arg Pro 
        755                 760                 765             


Ile Lys Arg Ser Leu Glu Asp Leu Asp Leu Val Ile Ala Gly Lys Lys 
    770                 775                 780                 


Ala Arg Ala Val Ser Pro Leu Asp Pro Ser Lys Glu Val Ser Gly Lys 
785                 790                 795                 800 


Glu Lys Ala Ser Glu Gln Glu Ser Glu Gly Ser Lys Ala Ala His Gly 
                805                 810                 815     


Gly His Ser Gly Gly Gly Ser Glu Gly His Lys Leu Pro Leu Ser Ser 
            820                 825                 830         


Pro Ile Phe Pro Gly Leu Tyr Ser Gly Ser Leu Cys Asn Ser Gly Leu 
        835                 840                 845             


Asn Ser Arg Leu Pro Ala Gly Tyr Ser His Ser Leu Gln Tyr Leu Lys 
    850                 855                 860                 


Asn Gln Thr Val Leu Ser Pro Leu Met Gln Pro Leu Ala Phe His Ser 
865                 870                 875                 880 


Leu Val Met Gln Arg Gly Ile Phe Thr Ser Pro Thr Asn Ser Gln Gln 
                885                 890                 895     


Leu Tyr Arg His Leu Ala Ala Ala Thr Pro Val Gly Ser Ser Tyr Gly 
            900                 905                 910         


Asp Leu Leu His Asn Ser Ile Tyr Pro Leu Ala Ala Ile Asn Pro Gln 
        915                 920                 925             


Ala Ala Phe Pro Ser Ser Gln Leu Ser Ser Val His Pro Ser Thr Lys 
    930                 935                 940                 


Leu 
945 


<210>  758
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARIH1__Homo_sapiens__NP_005735

<400>  758

Met Asp Ser Asp Glu Gly Tyr Asn Tyr Glu Phe Asp Glu Asp Glu Glu 
1               5                   10                  15      


Cys Ser Glu Glu Asp Ser Gly Ala Glu Glu Glu Glu Asp Glu Asp Asp 
            20                  25                  30          


Asp Glu Pro Asp Asp Asp Thr Leu Asp Leu Gly Glu Val Glu Leu Val 
        35                  40                  45              


Glu Pro Gly Leu Gly Val Gly Gly Glu Arg Asp Gly Leu Leu Cys Gly 
    50                  55                  60                  


Glu Thr Gly Gly Gly Gly Gly Ser Ala Leu Gly Pro Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro Gly His Glu Gln Glu 
                85                  90                  95      


Glu Asp Tyr Arg Tyr Glu Val Leu Thr Ala Glu Gln Ile Leu Gln His 
            100                 105                 110         


Met Val Glu Cys Ile Arg Glu Val Asn Glu Val Ile Gln Asn Pro Ala 
        115                 120                 125             


Thr Ile Thr Arg Ile Leu Leu Ser His Phe Asn Trp Asp Lys Glu Lys 
    130                 135                 140                 


Leu Met Glu Arg Tyr Phe Asp Gly Asn Leu Glu Lys Leu Phe Ala Glu 
145                 150                 155                 160 


Cys His Val Ile Asn Pro Ser Lys Lys Ser Arg Thr Arg Gln Met Asn 
                165                 170                 175     


Thr Arg Ser Ser Ala Gln Asp Met Pro Cys Gln Ile Cys Tyr Leu Asn 
            180                 185                 190         


Tyr Pro Asn Ser Tyr Phe Thr Gly Leu Glu Cys Gly His Lys Phe Cys 
        195                 200                 205             


Met Gln Cys Trp Ser Glu Tyr Leu Thr Thr Lys Ile Met Glu Glu Gly 
    210                 215                 220                 


Met Gly Gln Thr Ile Ser Cys Pro Ala His Gly Cys Asp Ile Leu Val 
225                 230                 235                 240 


Asp Asp Asn Thr Val Met Arg Leu Ile Thr Asp Ser Lys Val Lys Leu 
                245                 250                 255     


Lys Tyr Gln His Leu Ile Thr Asn Ser Phe Val Glu Cys Asn Arg Leu 
            260                 265                 270         


Leu Lys Trp Cys Pro Ala Pro Asp Cys His His Val Val Lys Val Gln 
        275                 280                 285             


Tyr Pro Asp Ala Lys Pro Val Arg Cys Lys Cys Gly Arg Gln Phe Cys 
    290                 295                 300                 


Phe Asn Cys Gly Glu Asn Trp His Asp Pro Val Lys Cys Lys Trp Leu 
305                 310                 315                 320 


Lys Lys Trp Ile Lys Lys Cys Asp Asp Asp Ser Glu Thr Ser Asn Trp 
                325                 330                 335     


Ile Ala Ala Asn Thr Lys Glu Cys Pro Lys Cys His Val Thr Ile Glu 
            340                 345                 350         


Lys Asp Gly Gly Cys Asn His Met Val Cys Arg Asn Gln Asn Cys Lys 
        355                 360                 365             


Ala Glu Phe Cys Trp Val Cys Leu Gly Pro Trp Glu Pro His Gly Ser 
    370                 375                 380                 


Ala Trp Tyr Asn Cys Asn Arg Tyr Asn Glu Asp Asp Ala Lys Ala Ala 
385                 390                 395                 400 


Arg Asp Ala Gln Glu Arg Ser Arg Ala Ala Leu Gln Arg Tyr Leu Phe 
                405                 410                 415     


Tyr Cys Asn Arg Tyr Met Asn His Met Gln Ser Leu Arg Phe Glu His 
            420                 425                 430         


Lys Leu Tyr Ala Gln Val Lys Gln Lys Met Glu Glu Met Gln Gln His 
        435                 440                 445             


Asn Met Ser Trp Ile Glu Val Gln Phe Leu Lys Lys Ala Val Asp Val 
    450                 455                 460                 


Leu Cys Gln Cys Arg Ala Thr Leu Met Tyr Thr Tyr Val Phe Ala Phe 
465                 470                 475                 480 


Tyr Leu Lys Lys Asn Asn Gln Ser Ile Ile Phe Glu Asn Asn Gln Ala 
                485                 490                 495     


Asp Leu Glu Asn Ala Thr Glu Val Leu Ser Gly Tyr Leu Glu Arg Asp 
            500                 505                 510         


Ile Ser Gln Asp Ser Leu Gln Asp Ile Lys Gln Lys Val Gln Asp Lys 
        515                 520                 525             


Tyr Arg Tyr Cys Glu Ser Arg Arg Arg Val Leu Leu Gln His Val His 
    530                 535                 540                 


Glu Gly Tyr Glu Lys Asp Leu Trp Glu Tyr Ile Glu Asp 
545                 550                 555         


<210>  759
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL11__Homo_sapiens__NP_612459

<400>  759

Met Gly Ser Val Asn Ser Arg Gly His Lys Ala Glu Ala Gln Val Val 
1               5                   10                  15      


Met Met Gly Leu Asp Ser Ala Gly Lys Thr Thr Leu Leu Tyr Lys Leu 
            20                  25                  30          


Lys Gly His Gln Leu Val Glu Thr Leu Pro Thr Val Gly Phe Asn Val 
        35                  40                  45              


Glu Pro Leu Lys Ala Pro Gly His Val Ser Leu Thr Leu Trp Asp Val 
    50                  55                  60                  


Gly Gly Gln Ala Pro Leu Arg Ala Ser Trp Lys Asp Tyr Leu Glu Gly 
65                  70                  75                  80  


Thr Asp Ile Leu Val Tyr Val Leu Asp Ser Thr Asp Glu Ala Arg Leu 
                85                  90                  95      


Pro Glu Ser Ala Ala Glu Leu Thr Glu Val Leu Asn Asp Pro Asn Met 
            100                 105                 110         


Ala Gly Val Pro Phe Leu Val Leu Ala Asn Lys Gln Glu Ala Pro Asp 
        115                 120                 125             


Ala Leu Pro Leu Leu Lys Ile Arg Asn Arg Leu Ser Leu Glu Arg Phe 
    130                 135                 140                 


Gln Asp His Cys Trp Glu Leu Arg Gly Cys Ser Ala Leu Thr Gly Glu 
145                 150                 155                 160 


Gly Leu Pro Glu Ala Leu Gln Ser Leu Trp Ser Leu Leu Lys Ser Arg 
                165                 170                 175     


Ser Cys Met Cys Leu Gln Ala Arg Ala His Gly Ala Glu Arg Gly Asp 
            180                 185                 190         


Ser Lys Arg Ser 
        195     


<210>  760
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL13A__Homo_sapiens__NP_001155963

<400>  760

Met Phe Arg Leu Leu Ser Ser Cys Cys Ser Cys Leu Arg Thr Thr Glu 
1               5                   10                  15      


Glu Thr Arg Arg Asn Val Thr Ile Pro Ile Ile Gly Leu Asn Asn Ser 
            20                  25                  30          


Gly Lys Thr Val Leu Val Glu Ala Phe Gln Lys Leu Leu Pro Ser Lys 
        35                  40                  45              


Thr Asp His Cys Met Lys Ser Glu Leu Thr Thr Leu Leu Leu Asp Glu 
    50                  55                  60                  


Tyr Glu Leu Ser Ile Tyr Asp Leu Asn Gly Asp Leu Lys Gly Arg Glu 
65                  70                  75                  80  


Ala Trp Pro Asn Tyr Tyr Ala Gln Ala His Gly Leu Val Phe Val Leu 
                85                  90                  95      


Asp Ser Ser Asp Ile Arg Arg Met Gln Glu Val Lys Ile Ile Leu Thr 
            100                 105                 110         


His Leu Leu Ser Asp Lys Arg Val Ala Gly Lys Pro Ile Leu Ile Leu 
        115                 120                 125             


Ala Asn Lys Gln Asp Lys Lys Lys Ala Leu Met Pro Cys Asp Ile Ile 
    130                 135                 140                 


Asp Tyr Leu Leu Leu Lys Lys Leu Val Lys Glu Asn Lys Cys Pro Cys 
145                 150                 155                 160 


Arg Val Glu Pro Cys Ser Ala Ile Arg Asn Leu Glu Arg Arg Asn His 
                165                 170                 175     


Gln Pro Ile Val Glu Gly Leu Arg Trp Leu Leu Ala Val Ile Asp Thr 
            180                 185                 190         


Cys Gln Leu Pro Pro Thr Ser Ser Ile Ser Ile Ser Lys Asn Asn Thr 
        195                 200                 205             


Gly Ser Gly Glu Arg Cys Ser Ser His Ser Phe Ser Thr Arg Thr Gly 
    210                 215                 220                 


Met Ser Lys Glu Lys Arg Gln His Leu Glu Gln Cys Ser Ile Glu Ala 
225                 230                 235                 240 


Lys Pro Leu Lys Ser Ile Leu Gln Pro Ser Asn Gln Ser Tyr Thr His 
                245                 250                 255     


<210>  761
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL13B__Homo_sapiens__NP_001167621

<400>  761

Met Phe Ser Leu Met Ala Ser Cys Cys Gly Trp Phe Lys Arg Trp Arg 
1               5                   10                  15      


Glu Pro Val Arg Lys Val Thr Leu Leu Met Val Gly Leu Asp Asn Ala 
            20                  25                  30          


Gly Lys Thr Ala Thr Ala Lys Gly Ile Gln Gly Glu Tyr Pro Glu Asp 
        35                  40                  45              


Val Ala Pro Thr Val Gly Phe Ser Lys Ile Asn Leu Arg Gln Gly Lys 
    50                  55                  60                  


Phe Glu Val Thr Ile Phe Asp Leu Gly Gly Gly Ile Arg Ile Arg Gly 
65                  70                  75                  80  


Ile Trp Lys Asn Tyr Tyr Ala Glu Ser Tyr Gly Val Ile Phe Val Val 
                85                  90                  95      


Asp Ser Ser Asp Glu Glu Arg Met Glu Glu Thr Lys Glu Ala Met Ser 
            100                 105                 110         


Glu Met Leu Arg His Pro Arg Ile Ser Gly Lys Pro Ile Leu Val Leu 
        115                 120                 125             


Ala Asn Lys Gln Asp Lys Glu Gly Ala Leu Gly Glu Ala Asp Val Ile 
    130                 135                 140                 


Glu Cys Leu Ser Leu Glu Lys Leu Val Asn Glu His Lys Cys Leu Cys 
145                 150                 155                 160 


Gln Ile Glu Pro Cys Ser Ala Ile Ser Gly Tyr Gly Lys Lys Ile Asp 
                165                 170                 175     


Lys Ser Ile Lys Lys Gly Leu Tyr Trp Leu Leu His Val Ile Ala Arg 
            180                 185                 190         


Asp Phe Asp Ala Leu Asn Glu Arg Ile Gln Lys Glu Thr Thr Glu Gln 
        195                 200                 205             


Arg Ala Leu Glu Glu Gln Glu Lys Gln Glu Arg Ala Glu Arg Val Arg 
    210                 215                 220                 


Lys Leu Arg Glu Glu Arg Lys Gln Asn Glu Gln Glu Gln Ala Glu Leu 
225                 230                 235                 240 


Asp Gly Thr Ser Gly Leu Ala Glu Leu Asp Pro Glu Pro Thr Asn Pro 
                245                 250                 255     


Phe Gln Pro Ile Ala Ser Val Ile Ile Glu Asn Glu Gly Lys Leu Glu 
            260                 265                 270         


Arg Glu Lys Lys Asn Gln Lys Met Glu Lys Asp Ser Asp Gly Cys His 
        275                 280                 285             


Leu Lys His Lys Met Glu His Glu Gln Ile Glu Thr Gln Gly Gln Val 
    290                 295                 300                 


Asn His Asn Gly Gln Lys Asn Asn Glu Phe Gly Leu Val Glu Asn Tyr 
305                 310                 315                 320 


Lys Glu Ala Leu Thr Gln Gln Leu Lys Asn Glu Asp Glu Thr Asp Arg 
                325                 330                 335     


Pro Ser Leu Glu Ser Ala Asn Gly Lys Lys Lys Thr Lys Lys Leu Arg 
            340                 345                 350         


Met Lys Arg Asn His Arg Val Glu Pro Leu Asn Ile Asp Asp Cys Ala 
        355                 360                 365             


Pro Glu Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Val Gly Trp Gly 
    370                 375                 380                 


Thr Pro Lys Val Thr Arg Leu Pro Lys Leu Glu Pro Leu Gly Glu Thr 
385                 390                 395                 400 


His His Asn Asp Phe Tyr Arg Lys Pro Leu Pro Pro Leu Ala Val Pro 
                405                 410                 415     


Gln Arg Pro Asn Ser Asp Ala His Asp Val Ile Ser 
            420                 425             


<210>  762
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL14EP__Homo_sapiens__NP_689529

<400>  762

Met Met Asp Pro Cys Ser Val Gly Val Gln Leu Arg Thr Thr Asn Glu 
1               5                   10                  15      


Cys His Lys Thr Tyr Tyr Thr Arg His Thr Gly Phe Lys Thr Leu Gln 
            20                  25                  30          


Glu Leu Ser Ser Asn Asp Met Leu Leu Leu Gln Leu Arg Thr Gly Met 
        35                  40                  45              


Thr Leu Ser Gly Asn Asn Thr Ile Cys Phe His His Val Lys Ile Tyr 
    50                  55                  60                  


Ile Asp Arg Phe Glu Asp Leu Gln Lys Ser Cys Cys Asp Pro Phe Asn 
65                  70                  75                  80  


Ile His Lys Lys Leu Ala Lys Lys Asn Leu His Val Ile Asp Leu Asp 
                85                  90                  95      


Asp Ala Thr Phe Leu Ser Ala Lys Phe Gly Arg Gln Leu Val Pro Gly 
            100                 105                 110         


Trp Lys Leu Cys Pro Lys Cys Thr Gln Ile Ile Asn Gly Ser Val Asp 
        115                 120                 125             


Val Asp Thr Glu Asp Arg Gln Lys Arg Lys Pro Glu Ser Asp Gly Arg 
    130                 135                 140                 


Thr Ala Lys Ala Leu Arg Ser Leu Gln Phe Thr Asn Pro Gly Arg Gln 
145                 150                 155                 160 


Thr Glu Phe Ala Pro Glu Thr Gly Lys Arg Glu Lys Arg Arg Leu Thr 
                165                 170                 175     


Lys Asn Ala Thr Ala Gly Ser Asp Arg Gln Val Ile Pro Ala Lys Ser 
            180                 185                 190         


Lys Val Tyr Asp Ser Gln Gly Leu Leu Ile Phe Ser Gly Met Asp Leu 
        195                 200                 205             


Cys Asp Cys Leu Asp Glu Asp Cys Leu Gly Cys Phe Tyr Ala Cys Pro 
    210                 215                 220                 


Ala Cys Gly Ser Thr Lys Cys Gly Ala Glu Cys Arg Cys Asp Arg Lys 
225                 230                 235                 240 


Trp Leu Tyr Glu Gln Ile Glu Ile Glu Gly Gly Glu Ile Ile His Asn 
                245                 250                 255     


Lys His Ala Gly 
            260 


<210>  763
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL14__Homo_sapiens__NP_079323

<400>  763

Met Gly Ser Leu Gly Ser Lys Asn Pro Gln Thr Lys Gln Ala Gln Val 
1               5                   10                  15      


Leu Leu Leu Gly Leu Asp Ser Ala Gly Lys Ser Thr Leu Leu Tyr Lys 
            20                  25                  30          


Leu Lys Leu Ala Lys Asp Ile Thr Thr Ile Pro Thr Ile Gly Phe Asn 
        35                  40                  45              


Val Glu Met Ile Glu Leu Glu Arg Asn Leu Ser Leu Thr Val Trp Asp 
    50                  55                  60                  


Val Gly Gly Gln Glu Lys Met Arg Thr Val Trp Gly Cys Tyr Cys Glu 
65                  70                  75                  80  


Asn Thr Asp Gly Leu Val Tyr Val Val Asp Ser Thr Asp Lys Gln Arg 
                85                  90                  95      


Leu Glu Glu Ser Gln Arg Gln Phe Glu His Ile Leu Lys Asn Glu His 
            100                 105                 110         


Ile Lys Asn Val Pro Val Val Leu Leu Ala Asn Lys Gln Asp Met Pro 
        115                 120                 125             


Gly Ala Leu Thr Ala Glu Asp Ile Thr Arg Met Phe Lys Val Lys Lys 
    130                 135                 140                 


Leu Cys Ser Asp Arg Asn Trp Tyr Val Gln Pro Cys Cys Ala Leu Thr 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Gln Gly Phe Arg Lys Leu Thr Gly Phe Val Lys 
                165                 170                 175     


Ser His Met Lys Ser Arg Gly Asp Thr Leu Ala Phe Phe Lys Gln Asn 
            180                 185                 190         


<210>  764
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL15__Homo_sapiens__NP_061960

<400>  764

Met Ser Asp Leu Arg Ile Thr Glu Ala Phe Leu Tyr Met Asp Tyr Leu 
1               5                   10                  15      


Cys Phe Arg Ala Leu Cys Cys Lys Gly Pro Pro Pro Ala Arg Pro Glu 
            20                  25                  30          


Tyr Asp Leu Val Cys Ile Gly Leu Thr Gly Ser Gly Lys Thr Ser Leu 
        35                  40                  45              


Leu Ser Lys Leu Cys Ser Glu Ser Pro Asp Asn Val Val Ser Thr Thr 
    50                  55                  60                  


Gly Phe Ser Ile Lys Ala Val Pro Phe Gln Asn Ala Ile Leu Asn Val 
65                  70                  75                  80  


Lys Glu Leu Gly Gly Ala Asp Asn Ile Arg Lys Tyr Trp Ser Arg Tyr 
                85                  90                  95      


Tyr Gln Gly Ser Gln Gly Val Ile Phe Val Leu Asp Ser Ala Ser Ser 
            100                 105                 110         


Glu Asp Asp Leu Glu Ala Ala Arg Asn Glu Leu His Ser Ala Leu Gln 
        115                 120                 125             


His Pro Gln Leu Cys Thr Leu Pro Phe Leu Ile Leu Ala Asn His Gln 
    130                 135                 140                 


Asp Lys Pro Ala Ala Arg Ser Val Gln Glu Ile Lys Lys Tyr Phe Glu 
145                 150                 155                 160 


Leu Glu Pro Leu Ala Arg Gly Lys Arg Trp Ile Leu Gln Pro Cys Ser 
                165                 170                 175     


Leu Asp Asp Met Asp Ala Leu Lys Asp Ser Phe Ser Gln Leu Ile Asn 
            180                 185                 190         


Leu Leu Glu Glu Lys Asp His Glu Ala Val Arg Met 
        195                 200                 


<210>  765
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL1__Homo_sapiens__NP_001168

<400>  765

Met Gly Gly Phe Phe Ser Ser Ile Phe Ser Ser Leu Phe Gly Thr Arg 
1               5                   10                  15      


Glu Met Arg Ile Leu Ile Leu Gly Leu Asp Gly Ala Gly Lys Thr Thr 
            20                  25                  30          


Ile Leu Tyr Arg Leu Gln Val Gly Glu Val Val Thr Thr Ile Pro Thr 
        35                  40                  45              


Ile Gly Phe Asn Val Glu Thr Val Thr Tyr Lys Asn Leu Lys Phe Gln 
    50                  55                  60                  


Val Trp Asp Leu Gly Gly Gln Thr Ser Ile Arg Pro Tyr Trp Arg Cys 
65                  70                  75                  80  


Tyr Tyr Ser Asn Thr Asp Ala Val Ile Tyr Val Val Asp Ser Cys Asp 
                85                  90                  95      


Arg Asp Arg Ile Gly Ile Ser Lys Ser Glu Leu Val Ala Met Leu Glu 
            100                 105                 110         


Glu Glu Glu Leu Arg Lys Ala Ile Leu Val Val Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Met Glu Gln Ala Met Thr Ser Ser Glu Met Ala Asn Ser Leu Gly 
    130                 135                 140                 


Leu Pro Ala Leu Lys Asp Arg Lys Trp Gln Ile Phe Lys Thr Ser Ala 
145                 150                 155                 160 


Thr Lys Gly Thr Gly Leu Asp Glu Ala Met Glu Trp Leu Val Glu Thr 
                165                 170                 175     


Leu Lys Ser Arg Gln 
            180     


<210>  766
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL2BP__Homo_sapiens__NP_036238

<400>  766

Met Asp Ala Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala 
1               5                   10                  15      


Ser Asp Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp Ile Ile 
            20                  25                  30          


Met Asp Asp Glu Phe Gln Leu Leu Gln Arg Asn Phe Met Asp Lys Tyr 
        35                  40                  45              


Tyr Leu Glu Phe Glu Asp Thr Glu Glu Asn Lys Leu Ile Tyr Thr Pro 
    50                  55                  60                  


Ile Phe Asn Glu Tyr Ile Ser Leu Val Glu Lys Tyr Ile Glu Glu Gln 
65                  70                  75                  80  


Leu Leu Gln Arg Ile Pro Glu Phe Asn Met Ala Ala Phe Thr Thr Thr 
                85                  90                  95      


Leu Gln His His Lys Asp Glu Val Ala Gly Asp Ile Phe Asp Met Leu 
            100                 105                 110         


Leu Thr Phe Thr Asp Phe Leu Ala Phe Lys Glu Met Phe Leu Asp Tyr 
        115                 120                 125             


Arg Ala Glu Lys Glu Gly Arg Gly Leu Asp Leu Ser Ser Gly Leu Val 
    130                 135                 140                 


Val Thr Ser Leu Cys Lys Ser Ser Ser Leu Pro Ala Ser Gln Asn Asn 
145                 150                 155                 160 


Leu Arg His 
            


<210>  767
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL2__Homo_sapiens__NP_001186674

<400>  767

Met Gly Leu Leu Thr Ile Leu Lys Lys Met Lys Gln Lys Glu Arg Glu 
1               5                   10                  15      


Leu Arg Leu Leu Met Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Lys Lys Phe Asn Gly Glu Asp Ile Asp Thr Ile Ser Pro Thr Leu 
        35                  40                  45              


Gly Phe Asn Ile Lys Thr Leu Glu His Arg Gly Phe Lys Leu Asn Ile 
    50                  55                  60                  


Trp Asp Val Gly Gly Gln Lys Ser Leu Arg Ser Tyr Trp Arg Asn Tyr 
65                  70                  75                  80  


Phe Glu Ser Thr Asp Gly Leu Ile Trp Val Val Asp Ser Ala Asp Arg 
                85                  90                  95      


Gln Arg Met Gln Asp Cys Gln Arg Glu Leu Gln Ser Leu Leu Val Glu 
            100                 105                 110         


Glu Val Leu Glu Leu Asp Ser Ile Arg Ser His His Trp Cys Ile Gln 
        115                 120                 125             


Gly Cys Ser Ala Val Thr Gly Glu Asn Leu Leu Pro Gly Ile Asp Trp 
    130                 135                 140                 


Leu Leu Asp Asp Ile Ser Ser Arg Ile Phe Thr Ala Asp 
145                 150                 155         


<210>  768
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL3__Homo_sapiens__NP_004302

<400>  768

Met Gly Leu Leu Ser Ile Leu Arg Lys Leu Lys Ser Ala Pro Asp Gln 
1               5                   10                  15      


Glu Val Arg Ile Leu Leu Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr 
            20                  25                  30          


Leu Leu Lys Gln Leu Ala Ser Glu Asp Ile Ser His Ile Thr Pro Thr 
        35                  40                  45              


Gln Gly Phe Asn Ile Lys Ser Val Gln Ser Gln Gly Phe Lys Leu Asn 
    50                  55                  60                  


Val Trp Asp Ile Gly Gly Gln Arg Lys Ile Arg Pro Tyr Trp Lys Asn 
65                  70                  75                  80  


Tyr Phe Glu Asn Thr Asp Ile Leu Ile Tyr Val Ile Asp Ser Ala Asp 
                85                  90                  95      


Arg Lys Arg Phe Glu Glu Thr Gly Gln Glu Leu Ala Glu Leu Leu Glu 
            100                 105                 110         


Glu Glu Lys Leu Ser Cys Val Pro Val Leu Ile Phe Ala Asn Lys Gln 
        115                 120                 125             


Asp Leu Leu Thr Ala Ala Pro Ala Ser Glu Ile Ala Glu Gly Leu Asn 
    130                 135                 140                 


Leu His Thr Ile Arg Asp Arg Val Trp Gln Ile Gln Ser Cys Ser Ala 
145                 150                 155                 160 


Leu Thr Gly Glu Gly Val Gln Asp Gly Met Asn Trp Val Cys Lys Asn 
                165                 170                 175     


Val Asn Ala Lys Lys Lys 
            180         


<210>  769
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL4A__Homo_sapiens__NP_001182325

<400>  769

Met Gly Asn Gly Leu Ser Asp Gln Thr Ser Ile Leu Ser Asn Leu Pro 
1               5                   10                  15      


Ser Phe Gln Ser Phe His Ile Val Ile Leu Gly Leu Asp Cys Ala Gly 
            20                  25                  30          


Lys Thr Thr Val Leu Tyr Arg Leu Gln Phe Asn Glu Phe Val Asn Thr 
        35                  40                  45              


Val Pro Thr Lys Gly Phe Asn Thr Glu Lys Ile Lys Val Thr Leu Gly 
    50                  55                  60                  


Asn Ser Lys Thr Val Thr Phe His Phe Trp Asp Val Gly Gly Gln Glu 
65                  70                  75                  80  


Lys Leu Arg Pro Leu Trp Lys Ser Tyr Thr Arg Cys Thr Asp Gly Ile 
                85                  90                  95      


Val Phe Val Val Asp Ser Val Asp Val Glu Arg Met Glu Glu Ala Lys 
            100                 105                 110         


Thr Glu Leu His Lys Ile Thr Arg Ile Ser Glu Asn Gln Gly Val Pro 
        115                 120                 125             


Val Leu Ile Val Ala Asn Lys Gln Asp Leu Arg Asn Ser Leu Ser Leu 
    130                 135                 140                 


Ser Glu Ile Glu Lys Leu Leu Ala Met Gly Glu Leu Ser Ser Ser Thr 
145                 150                 155                 160 


Pro Trp His Leu Gln Pro Thr Cys Ala Ile Ile Gly Asp Gly Leu Lys 
                165                 170                 175     


Glu Gly Leu Glu Lys Leu His Asp Met Ile Ile Lys Arg Arg Lys Met 
            180                 185                 190         


Leu Arg Gln Gln Lys Lys Lys Arg 
        195                 200 


<210>  770
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL4C__Homo_sapiens__NP_001269360

<400>  770

Met Gly Asn Ile Ser Ser Asn Ile Ser Ala Phe Gln Ser Leu His Ile 
1               5                   10                  15      


Val Met Leu Gly Leu Asp Ser Ala Gly Lys Thr Thr Val Leu Tyr Arg 
            20                  25                  30          


Leu Lys Phe Asn Glu Phe Val Asn Thr Val Pro Thr Ile Gly Phe Asn 
        35                  40                  45              


Thr Glu Lys Ile Lys Leu Ser Asn Gly Thr Ala Lys Gly Ile Ser Cys 
    50                  55                  60                  


His Phe Trp Asp Val Gly Gly Gln Glu Lys Leu Arg Pro Leu Trp Lys 
65                  70                  75                  80  


Ser Tyr Ser Arg Cys Thr Asp Gly Ile Ile Tyr Val Val Asp Ser Val 
                85                  90                  95      


Asp Val Asp Arg Leu Glu Glu Ala Lys Thr Glu Leu His Lys Val Thr 
            100                 105                 110         


Lys Phe Ala Glu Asn Gln Gly Thr Pro Leu Leu Val Ile Ala Asn Lys 
        115                 120                 125             


Gln Asp Leu Pro Lys Ser Leu Pro Val Ala Glu Ile Glu Lys Gln Leu 
    130                 135                 140                 


Ala Leu His Glu Leu Ile Pro Ala Thr Thr Tyr His Val Gln Pro Ala 
145                 150                 155                 160 


Cys Ala Ile Ile Gly Glu Gly Leu Thr Glu Gly Met Asp Lys Leu Tyr 
                165                 170                 175     


Glu Met Ile Leu Lys Arg Arg Lys Ser Leu Lys Gln Lys Lys Lys Arg 
            180                 185                 190         


Thr Gly Asp Leu Arg Ser Cys Glu Val 
        195                 200     


<210>  771
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL4D__Homo_sapiens__NP_001652

<400>  771

Met Gly Asn His Leu Thr Glu Met Ala Pro Thr Ala Ser Ser Phe Leu 
1               5                   10                  15      


Pro His Phe Gln Ala Leu His Val Val Val Ile Gly Leu Asp Ser Ala 
            20                  25                  30          


Gly Lys Thr Ser Leu Leu Tyr Arg Leu Lys Phe Lys Glu Phe Val Gln 
        35                  40                  45              


Ser Val Pro Thr Lys Gly Phe Asn Thr Glu Lys Ile Arg Val Pro Leu 
    50                  55                  60                  


Gly Gly Ser Arg Gly Ile Thr Phe Gln Val Trp Asp Val Gly Gly Gln 
65                  70                  75                  80  


Glu Lys Leu Arg Pro Leu Trp Arg Ser Tyr Thr Arg Arg Thr Asp Gly 
                85                  90                  95      


Leu Val Phe Val Val Asp Ala Ala Glu Ala Glu Arg Leu Glu Glu Ala 
            100                 105                 110         


Lys Val Glu Leu His Arg Ile Ser Arg Ala Ser Asp Asn Gln Gly Val 
        115                 120                 125             


Pro Val Leu Val Leu Ala Asn Lys Gln Asp Gln Pro Gly Ala Leu Ser 
    130                 135                 140                 


Ala Ala Glu Val Glu Lys Arg Leu Ala Val Arg Glu Leu Ala Ala Ala 
145                 150                 155                 160 


Thr Leu Thr His Val Gln Gly Cys Ser Ala Val Asp Gly Leu Gly Leu 
                165                 170                 175     


Gln Gln Gly Leu Glu Arg Leu Tyr Glu Met Ile Leu Lys Arg Lys Lys 
            180                 185                 190         


Ala Ala Arg Gly Gly Lys Lys Arg Arg 
        195                 200     


<210>  772
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL5A__Homo_sapiens__NP_001032251

<400>  772

Met Asn Glu Val Val His Thr Ser Pro Thr Ile Gly Ser Asn Val Glu 
1               5                   10                  15      


Glu Ile Val Ile Asn Asn Thr Arg Phe Leu Met Trp Asp Ile Gly Gly 
            20                  25                  30          


Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr Tyr Thr Asn Thr Glu 
        35                  40                  45              


Phe Val Ile Val Val Val Asp Ser Thr Asp Arg Glu Arg Ile Ser Val 
    50                  55                  60                  


Thr Arg Glu Glu Leu Tyr Lys Met Leu Ala His Glu Asp Leu Arg Lys 
65                  70                  75                  80  


Ala Gly Leu Leu Ile Phe Ala Asn Lys Gln Asp Val Lys Glu Cys Met 
                85                  90                  95      


Thr Val Ala Glu Ile Ser Gln Phe Leu Lys Leu Thr Ser Ile Lys Asp 
            100                 105                 110         


His Gln Trp His Ile Gln Ala Cys Cys Ala Leu Thr Gly Glu Gly Leu 
        115                 120                 125             


Cys Gln Gly Leu Glu Trp Met Met Ser Arg Leu Lys Ile Arg 
    130                 135                 140         


<210>  773
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL5B__Homo_sapiens__NP_848930

<400>  773

Met Gly Leu Ile Phe Ala Lys Leu Trp Ser Leu Phe Cys Asn Gln Glu 
1               5                   10                  15      


His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys Thr Thr Ile 
            20                  25                  30          


Leu Tyr Gln Phe Leu Met Asn Glu Val Val His Thr Ser Pro Thr Ile 
        35                  40                  45              


Gly Ser Asn Val Glu Glu Ile Val Val Lys Asn Thr His Phe Leu Met 
    50                  55                  60                  


Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp Asn Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asn Thr Glu Phe Ile Ile Leu Val Val Asp Ser Ile Asp Arg 
                85                  90                  95      


Glu Arg Leu Ala Ile Thr Lys Glu Glu Leu Tyr Arg Met Leu Ala His 
            100                 105                 110         


Glu Asp Leu Arg Lys Ala Ala Val Leu Ile Phe Ala Asn Lys Gln Asp 
        115                 120                 125             


Met Lys Gly Cys Met Thr Ala Ala Glu Ile Ser Lys Tyr Leu Thr Leu 
    130                 135                 140                 


Ser Ser Ile Lys Asp His Pro Trp His Ile Gln Ser Cys Cys Ala Leu 
145                 150                 155                 160 


Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Thr Ser Arg Ile 
                165                 170                 175     


Gly Val Arg 
            


<210>  774
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL6__Homo_sapiens__NP_816931

<400>  774

Met Gly Leu Leu Asp Arg Leu Ser Val Leu Leu Gly Leu Lys Lys Lys 
1               5                   10                  15      


Glu Val His Val Leu Cys Leu Gly Leu Asp Asn Ser Gly Lys Thr Thr 
            20                  25                  30          


Ile Ile Asn Lys Leu Lys Pro Ser Asn Ala Gln Ser Gln Asn Ile Leu 
        35                  40                  45              


Pro Thr Ile Gly Phe Ser Ile Glu Lys Phe Lys Ser Ser Ser Leu Ser 
    50                  55                  60                  


Phe Thr Val Phe Asp Met Ser Gly Gln Gly Arg Tyr Arg Asn Leu Trp 
65                  70                  75                  80  


Glu His Tyr Tyr Lys Glu Gly Gln Ala Ile Ile Phe Val Ile Asp Ser 
                85                  90                  95      


Ser Asp Arg Leu Arg Met Val Val Ala Lys Glu Glu Leu Asp Thr Leu 
            100                 105                 110         


Leu Asn His Pro Asp Ile Lys His Arg Arg Ile Pro Ile Leu Phe Phe 
        115                 120                 125             


Ala Asn Lys Met Asp Leu Arg Asp Ala Val Thr Ser Val Lys Val Ser 
    130                 135                 140                 


Gln Leu Leu Cys Leu Glu Asn Ile Lys Asp Lys Pro Trp His Ile Cys 
145                 150                 155                 160 


Ala Ser Asp Ala Ile Lys Gly Glu Gly Leu Gln Glu Gly Val Asp Trp 
                165                 170                 175     


Leu Gln Asp Gln Ile Gln Thr Val Lys Thr 
            180                 185     


<210>  775
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL6IP1__Homo_sapiens__NP_055976

<400>  775

Met Ala Glu Gly Asp Asn Arg Ser Thr Asn Leu Leu Ala Ala Glu Thr 
1               5                   10                  15      


Ala Ser Leu Glu Glu Gln Leu Gln Gly Trp Gly Glu Val Met Leu Met 
            20                  25                  30          


Ala Asp Lys Val Leu Arg Trp Glu Arg Ala Trp Phe Pro Pro Ala Ile 
        35                  40                  45              


Met Gly Val Val Ser Leu Val Phe Leu Ile Ile Tyr Tyr Leu Asp Pro 
    50                  55                  60                  


Ser Val Leu Ser Gly Val Ser Cys Phe Val Met Phe Leu Cys Leu Ala 
65                  70                  75                  80  


Asp Tyr Leu Val Pro Ile Leu Ala Pro Arg Ile Phe Gly Ser Asn Lys 
                85                  90                  95      


Trp Thr Thr Glu Gln Gln Gln Arg Phe His Glu Ile Cys Ser Asn Leu 
            100                 105                 110         


Val Lys Thr Arg Arg Arg Ala Val Gly Trp Trp Lys Arg Leu Phe Thr 
        115                 120                 125             


Leu Lys Glu Glu Lys Pro Lys Met Tyr Phe Met Thr Met Ile Val Ser 
    130                 135                 140                 


Leu Ala Ala Val Ala Trp Val Gly Gln Gln Val His Asn Leu Leu Leu 
145                 150                 155                 160 


Thr Tyr Leu Ile Val Thr Ser Leu Leu Leu Leu Pro Gly Leu Asn Gln 
                165                 170                 175     


His Gly Ile Ile Leu Lys Tyr Ile Gly Met Ala Lys Arg Glu Ile Asn 
            180                 185                 190         


Lys Leu Leu Lys Gln Lys Glu Lys Lys Asn Glu 
        195                 200             


<210>  776
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARL6IP5__Homo_sapiens__NP_006398

<400>  776

Met Asp Val Asn Ile Ala Pro Leu Arg Ala Trp Asp Asp Phe Phe Pro 
1               5                   10                  15      


Gly Ser Asp Arg Phe Ala Arg Pro Asp Phe Arg Asp Ile Ser Lys Trp 
            20                  25                  30          


Asn Asn Arg Val Val Ser Asn Leu Leu Tyr Tyr Gln Thr Asn Tyr Leu 
        35                  40                  45              


Val Val Ala Ala Met Met Ile Ser Ile Val Gly Phe Leu Ser Pro Phe 
    50                  55                  60                  


Asn Met Ile Leu Gly Gly Ile Val Val Val Leu Val Phe Thr Gly Phe 
65                  70                  75                  80  


Val Trp Ala Ala His Asn Lys Asp Val Leu Arg Arg Met Lys Lys Arg 
                85                  90                  95      


Tyr Pro Thr Thr Phe Val Met Val Val Met Leu Ala Ser Tyr Phe Leu 
            100                 105                 110         


Ile Ser Met Phe Gly Gly Val Met Val Phe Val Phe Gly Ile Thr Phe 
        115                 120                 125             


Pro Leu Leu Leu Met Phe Ile His Ala Ser Leu Arg Leu Arg Asn Leu 
    130                 135                 140                 


Lys Asn Lys Leu Glu Asn Lys Met Glu Gly Ile Gly Leu Lys Arg Thr 
145                 150                 155                 160 


Pro Met Gly Ile Val Leu Asp Ala Leu Glu Gln Gln Glu Glu Gly Ile 
                165                 170                 175     


Asn Arg Leu Thr Asp Tyr Ile Ser Lys Val Lys Glu 
            180                 185             


<210>  777
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC10__Homo_sapiens__NP_001154481

<400>  777

Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 
            20                  25                  30          


Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Glu Asp 
        35                  40                  45              


Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu Gln Leu Gln 
    50                  55                  60                  


Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val Ile Ile Glu 
65                  70                  75                  80  


Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser Val Asn Gln 
                85                  90                  95      


Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala Asn Lys Ile 
            100                 105                 110         


Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn Ala Leu Asn 
        115                 120                 125             


Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys Ile Tyr Ile 
    130                 135                 140                 


Ser Gln Val Cys Glu Asp Val Phe Ser Gly Pro Leu Asn Ser Ala Val 
145                 150                 155                 160 


Gln Leu Ala Gly Leu Thr Leu Leu Thr Asn Met Thr Val Thr Asn Asp 
                165                 170                 175     


His Gln His Met Leu His Ser Tyr Ile Thr Asp Leu Phe Gln Val Leu 
            180                 185                 190         


Leu Thr Gly Asn Gly Asn Thr Lys Val Gln Val Leu Lys Leu Leu Leu 
        195                 200                 205             


Asn Leu Ser Glu Asn Pro Ala Met Thr Glu Gly Leu Leu Arg Ala Gln 
    210                 215                 220                 


Val Asp Ser Ser Phe Leu Ser Leu Tyr Asp Ser His Val Ala Lys Glu 
225                 230                 235                 240 


Ile Leu Leu Arg Val Leu Thr Leu Phe Gln Asn Ile Lys Asn Cys Leu 
                245                 250                 255     


Lys Ile Glu Gly His Leu Ala Val Gln Pro Thr Phe Thr Glu Gly Ser 
            260                 265                 270         


Leu Phe Phe Leu Leu His Gly Glu Glu Cys Ala Gln Lys Ile Arg Ala 
        275                 280                 285             


Leu Val Asp His His Asp Ala Glu Val Lys Glu Lys Val Val Thr Ile 
    290                 295                 300                 


Ile Pro Lys Ile 
305             


<210>  778
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC1__Homo_sapiens__NP_001273631

<400>  778

Met Ser Ala Trp Pro Tyr Phe Ile Tyr Gly Pro Ser Gln Pro Ser Ser 
1               5                   10                  15      


Arg Pro Leu Arg Phe Ala Cys Ser Ser Ile Leu Gly Arg Met Pro Cys 
            20                  25                  30          


Lys Gln Arg Lys Asp Glu Arg Arg Thr Gly Tyr Asp Val Glu Leu Thr 
        35                  40                  45              


Lys Cys Tyr Thr Glu Ser Arg Arg Asn Leu Cys Glu Glu Ala Leu Leu 
    50                  55                  60                  


Lys Ile Lys Gly Val Ile Ser Phe Thr Phe Gln Met Ala Val Gln Arg 
65                  70                  75                  80  


Cys Val Val Arg Ile Arg Ser Asp Leu Lys Ala Glu Ala Leu Ala Ser 
                85                  90                  95      


Ala Ile Ala Ser Thr Lys Val Met Lys Ala Gln Gln Val Val Lys Ser 
            100                 105                 110         


Glu Ser Gly Glu Glu Met Leu Val Pro Phe Gln Asp Thr Pro Val Glu 
        115                 120                 125             


Val Glu Gln Asn Thr Glu Leu Pro Asp Tyr Leu Pro Glu Asp Glu Ser 
    130                 135                 140                 


Pro Thr Lys Glu Gln Asp Lys Ala Val Ser Arg Val Gly Ser His Pro 
145                 150                 155                 160 


Glu Gly Gly Ala Ser Trp Leu Ser Thr Ala Ala Asn Phe Leu Ser Arg 
                165                 170                 175     


Ser Phe Tyr Trp 
            180 


<210>  779
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC2__Homo_sapiens__NP_115507

<400>  779

Met Leu Ser Pro Asn Asp Lys Met Leu Gly Lys Leu Asp Pro Phe Tyr 
1               5                   10                  15      


Gln Pro Ser Val Ser Lys Gln Lys Thr Ser Ala Glu Ile Ile Ser Glu 
            20                  25                  30          


Ala Arg Asn Ala Leu Arg Thr Val Arg Thr Gln Arg Pro Phe Thr Pro 
        35                  40                  45              


Gln Glu Ala Gln Arg Lys Leu Phe Gly Pro Ala Ser Ser Arg Thr Ser 
    50                  55                  60                  


Glu Asn Arg Pro Pro Ser Ser Phe Ser Leu His Ala Ser Ser Phe Glu 
65                  70                  75                  80  


Ser Ser Asp Ser Arg Pro Ile Ser Gly Thr Arg Leu Ser Pro Leu Glu 
                85                  90                  95      


Leu Lys Pro Lys Val Pro Ala Ser Pro Thr Arg Glu Glu Asp Ser Cys 
            100                 105                 110         


Phe Ser Phe Pro Lys Pro Pro Val Asp Pro Ala Lys Ile Arg Arg Val 
        115                 120                 125             


Ser Asn Ala Arg Ala Arg Leu Phe Arg Ala Ala Ser Gln Arg Ala Leu 
    130                 135                 140                 


Leu Pro Asp Arg Ser Leu Pro Pro Ser Asp Ser Lys Lys Thr Val Glu 
145                 150                 155                 160 


Ser Lys Glu Thr Val Met Met Gly Asp Ser Met Val Lys Ile Asn Gly 
                165                 170                 175     


Ile Tyr Leu Thr Lys Ser Asn Ala Ile Cys His Leu Lys Ser His Pro 
            180                 185                 190         


Leu Gln Leu Thr Asp Asp Gly Gly Phe Ser Glu Ile Lys Glu Gln Glu 
        195                 200                 205             


Met Phe Lys Gly Thr Thr Ser Leu Pro Ser His Leu Lys Asn Gly Gly 
    210                 215                 220                 


Asp Gln Gly Lys Arg His Ala Arg Ala Ser Ser Cys Pro Ser Ser Ser 
225                 230                 235                 240 


Asp Leu Ser Arg Leu Gln Thr Lys Ala Val Pro Lys Ala Asp Leu Gln 
                245                 250                 255     


Glu Glu Asp Ala Glu Ile Glu Val Asp Glu Val Phe Trp Asn Thr Arg 
            260                 265                 270         


Ile Val Pro Ile Leu Arg Glu Leu Glu Lys Glu Glu Asn Ile Glu Thr 
        275                 280                 285             


Val Cys Ala Ala Cys Thr Gln Leu His His Ala Leu Glu Glu Gly Asn 
    290                 295                 300                 


Met Leu Gly Asn Lys Phe Lys Gly Arg Ser Ile Leu Leu Lys Thr Leu 
305                 310                 315                 320 


Cys Lys Leu Val Asp Val Gly Ser Asp Ser Leu Ser Leu Lys Leu Ala 
                325                 330                 335     


Lys Ile Ile Leu Ala Leu Lys Val Ser Arg Lys Asn Leu Leu Asn Val 
            340                 345                 350         


Cys Lys Leu Ile Phe Lys Ile Ser Arg Asn Glu Lys Asn Asp Ser Leu 
        355                 360                 365             


Ile Gln Asn Asp Ser Ile Leu Glu Ser Leu Leu Glu Val Leu Arg Ser 
    370                 375                 380                 


Glu Asp Leu Gln Thr Asn Met Glu Ala Phe Leu Tyr Cys Met Gly Ser 
385                 390                 395                 400 


Ile Lys Phe Ile Ser Gly Asn Leu Gly Phe Leu Asn Glu Met Ile Ser 
                405                 410                 415     


Lys Gly Ala Val Glu Ile Leu Ile Asn Leu Ile Lys Gln Ile Asn Glu 
            420                 425                 430         


Asn Ile Lys Lys Cys Gly Thr Phe Leu Pro Asn Ser Gly His Leu Leu 
        435                 440                 445             


Val Gln Val Thr Ala Thr Leu Arg Asn Leu Val Asp Ser Ser Leu Val 
    450                 455                 460                 


Arg Ser Lys Phe Leu Asn Ile Ser Ala Leu Pro Gln Leu Cys Thr Ala 
465                 470                 475                 480 


Met Glu Gln Tyr Lys Gly Asp Lys Asp Val Cys Thr Asn Ile Ala Arg 
                485                 490                 495     


Ile Phe Ser Lys Leu Thr Ser Tyr Arg Asp Cys Cys Thr Ala Leu Ala 
            500                 505                 510         


Ser Tyr Ser Arg Cys Tyr Ala Leu Phe Leu Asn Leu Ile Asn Lys Tyr 
        515                 520                 525             


Gln Lys Lys Gln Asp Leu Val Val Arg Val Val Phe Ile Leu Gly Asn 
    530                 535                 540                 


Leu Thr Ala Lys Asn Asn Gln Ala Arg Glu Gln Phe Ser Lys Glu Lys 
545                 550                 555                 560 


Gly Ser Ile Gln Thr Leu Leu Ser Leu Phe Gln Thr Phe His Gln Leu 
                565                 570                 575     


Asp Leu His Ser Gln Lys Pro Val Gly Gln Arg Gly Glu Gln His Arg 
            580                 585                 590         


Ala Gln Arg Pro Pro Ser Glu Ala Glu Asp Val Leu Ile Lys Leu Thr 
        595                 600                 605             


Arg Val Leu Ala Asn Ile Ala Ile His Pro Gly Val Gly Pro Val Leu 
    610                 615                 620                 


Ala Ala Asn Pro Gly Ile Val Gly Leu Leu Leu Thr Thr Leu Glu Tyr 
625                 630                 635                 640 


Lys Ser Leu Asp Asp Cys Glu Glu Leu Val Ile Asn Ala Thr Ala Thr 
                645                 650                 655     


Ile Asn Asn Leu Ser Tyr Tyr Gln Val Lys Asn Ser Ile Ile Gln Asp 
            660                 665                 670         


Lys Lys Leu Tyr Ile Ala Glu Leu Leu Leu Lys Leu Leu Val Ser Asn 
        675                 680                 685             


Asn Met Asp Gly Ile Leu Glu Ala Val Arg Val Phe Gly Asn Leu Ser 
    690                 695                 700                 


Gln Asp His Asp Val Cys Asp Phe Ile Val Gln Asn Asn Val His Arg 
705                 710                 715                 720 


Phe Met Met Ala Leu Leu Asp Ala Gln His Gln Asp Ile Cys Phe Ser 
                725                 730                 735     


Ala Cys Gly Val Leu Leu Asn Leu Thr Val Asp Lys Asp Lys Arg Val 
            740                 745                 750         


Ile Leu Lys Glu Gly Gly Gly Ile Lys Lys Leu Val Asp Cys Leu Arg 
        755                 760                 765             


Asp Leu Gly Pro Thr Asp Trp Gln Leu Ala Cys Leu Val Cys Lys Thr 
    770                 775                 780                 


Leu Trp Asn Phe Ser Glu Asn Ile Thr Asn Ala Ser Ser Cys Phe Gly 
785                 790                 795                 800 


Asn Glu Asp Thr Asn Thr Leu Leu Leu Leu Leu Ser Ser Phe Leu Asp 
                805                 810                 815     


Glu Glu Leu Ala Leu Asp Gly Ser Phe Asp Pro Asp Leu Lys Asn Tyr 
            820                 825                 830         


His Lys Leu His Trp Glu Thr Glu Phe Lys Pro Val Ala Gln Gln Leu 
        835                 840                 845             


Leu Asn Arg Ile Gln Arg His His Thr Phe Leu Glu Pro Leu Pro Ile 
    850                 855                 860                 


Pro Ser Phe 
865         


<210>  780
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC3__Homo_sapiens__NP_001269674

<400>  780

Met Gly Lys Lys Ile Lys Lys Glu Val Glu Pro Pro Pro Lys Asp Val 
1               5                   10                  15      


Phe Asp Pro Leu Met Ile Glu Ser Lys Lys Ala Ala Thr Val Val Leu 
            20                  25                  30          


Met Leu Asn Ser Pro Glu Glu Glu Ile Leu Ala Lys Ala Cys Glu Ala 
        35                  40                  45              


Ile Tyr Lys Phe Ala Leu Lys Gly Glu Glu Asn Lys Thr Thr Leu Leu 
    50                  55                  60                  


Glu Leu Gly Ala Val Glu Pro Leu Thr Lys Leu Leu Thr His Glu Asp 
65                  70                  75                  80  


Lys Ile Val Arg Arg Asn Ala Thr Met Ile Phe Gly Ile Leu Ala Ser 
                85                  90                  95      


Asn Asn Asp Val Lys Lys Leu Leu Arg Glu Leu Asp Val Met Asn Ser 
            100                 105                 110         


Val Ile Ala Gln Leu Ala Pro Glu Glu Glu Val Val Ile His Glu Phe 
        115                 120                 125             


Ala Ser Leu Cys Leu Ala Asn Met Ser Ala Glu Tyr Thr Ser Lys Val 
    130                 135                 140                 


Gln Ile Phe Glu His Gly Gly Leu Glu Pro Leu Ile Arg Leu Leu Ser 
145                 150                 155                 160 


Ser Pro Asp Pro Asp Val Lys Lys Asn Ser Met Glu Cys Ile Tyr Asn 
                165                 170                 175     


Leu Val Gln Asp Phe Gln Cys Arg Ala Lys Leu Gln Glu Leu Asn Ala 
            180                 185                 190         


Ile Pro Pro Ile Leu Asp Leu Leu Lys Ser Glu Tyr Pro Val Ile Gln 
        195                 200                 205             


Leu Leu Ala Leu Lys Thr Leu Gly Val Ile Ala Asn Asp Lys Glu Ser 
    210                 215                 220                 


Arg Thr Met Leu Arg Asp Asn Gln Gly Leu Asp His Leu Ile Lys Ile 
225                 230                 235                 240 


Leu Glu Thr Lys Glu Leu Asn Asp Leu His Ile Glu Ala Leu Ala Val 
                245                 250                 255     


Ile Ala Asn Cys Leu Glu Asp Met Asp Thr Met Val Gln Ile Gln Gln 
            260                 265                 270         


Thr Gly Gly Leu Lys Lys Leu Leu Ser Phe Ala Glu Asn Ser Thr Ile 
        275                 280                 285             


Pro Asp Ile Gln Lys Asn Ala Ala Lys Ala Ile Thr Lys Ala Ala Tyr 
    290                 295                 300                 


Asp Pro Glu Asn Arg Lys Leu Phe His Glu Gln Glu Val Glu Lys Cys 
305                 310                 315                 320 


Leu Val Ala Leu Leu Gly Ser Glu Asn Asp Gly Thr Lys Ile Ala Ala 
                325                 330                 335     


Ser Gln Ala Ile Ser Ala Met Cys Glu Asn Ser Gly Ser Lys Asp Phe 
            340                 345                 350         


Phe Asn Asn Gln Gly Ile Pro Gln Leu Ile Gln Leu Leu Lys Ser Asp 
        355                 360                 365             


Asn Glu Glu Val Arg Glu Ala Ala Ala Leu Ala Leu Ala Asn Leu Thr 
    370                 375                 380                 


Thr Cys Asn Pro Ala Asn Ala Asn Ala Ala Ala Glu Ala Asp Gly Ile 
385                 390                 395                 400 


Asp Pro Leu Ile Asn Leu Leu Ser Ser Lys Arg Asp Gly Ala Ile Ala 
                405                 410                 415     


Asn Ala Ala Thr Val Leu Thr Asn Met Ala Met Gln Glu Pro Leu Arg 
            420                 425                 430         


Leu Asn Ile Gln Asn His Asp Ile Met His Ala Ile Ile Ser Pro Leu 
        435                 440                 445             


Arg Ser Ala Asn Thr Val Val Gln Ser Lys Ala Ala Leu Ala Val Thr 
    450                 455                 460                 


Ala Thr Ala Cys Asp Val Glu Ala Arg Thr Glu Leu Arg Asn Ser Gly 
465                 470                 475                 480 


Gly Leu Glu Pro Leu Val Glu Leu Leu Arg Ser Lys Asn Asp Glu Val 
                485                 490                 495     


Arg Lys His Ala Ser Trp Ala Val Met Val Cys Ala Gly Asp Glu Leu 
            500                 505                 510         


Thr Ala Asn Glu Leu Cys Arg Leu Gly Ala Leu Asp Ile Leu Glu Glu 
        515                 520                 525             


Val Asn Val Ser Gly Thr Arg Lys Asn Lys Phe Ser Glu Ala Ala Tyr 
    530                 535                 540                 


Asn Lys Leu Leu Asn Asn Asn Leu Ser Leu Lys Tyr Ser Gln Thr Gly 
545                 550                 555                 560 


Tyr Leu Ser Ser Ser Asn Ile Ile Asn Asp Gly Phe Tyr Asp Tyr Gly 
                565                 570                 575     


Arg Ile Asn Pro Gly Thr Lys Leu Leu Pro Leu Lys Glu Leu Cys Leu 
            580                 585                 590         


Gln Glu Pro Ser Asp Leu Arg Ala Val Leu Leu Ile Asn Ser Lys Ser 
        595                 600                 605             


Tyr Val Ser Pro Pro Ser Ser Met Glu Asp Lys Ser Asp Val Gly Tyr 
    610                 615                 620                 


Gly Arg Ser Ile Ser Ser Ser Ser Ser Leu Arg Arg Ser Ser Lys Glu 
625                 630                 635                 640 


Lys Asn Asn Ala Gly Phe Gly Ser Pro Ile Glu Asp Lys Ser Glu Pro 
                645                 650                 655     


Ala Ser Gly Arg Asn Thr Val Leu Ser Lys Ser Ala Thr Lys Glu Lys 
            660                 665                 670         


Gly Trp Arg Lys Ser Lys Gly Lys Lys Glu Glu Glu Lys Val Lys Glu 
        675                 680                 685             


Glu Glu Glu Val Met Val Val Pro Lys Phe Val Gly Glu Gly Ser Ser 
    690                 695                 700                 


Asp Lys Glu Trp Cys Pro Pro Ser Asp Pro Asp Phe Ser Met Tyr Val 
705                 710                 715                 720 


Tyr Glu Val Thr Lys Ser Ile Leu Pro Ile Thr Asn Ile Lys Glu Gln 
                725                 730                 735     


Ile Glu Asp Leu Ala Lys Tyr Val Ala Glu Lys Met Gly Gly Lys Ile 
            740                 745                 750         


Pro Lys Glu Lys Leu Pro Asp Phe Ser Trp Glu Leu His Ile Ser Glu 
        755                 760                 765             


Leu Lys Phe Gln Leu Lys Ser Asn Val Ile Pro Ile Gly His Val Lys 
    770                 775                 780                 


Lys Gly Ile Phe Tyr His Arg Ala Leu Leu Phe Lys Ala Leu Ala Asp 
785                 790                 795                 800 


Arg Ile Gly Ile Gly Cys Ser Leu Val Arg Gly Glu Tyr Gly Arg Ala 
                805                 810                 815     


Trp Asn Glu Val Met Leu Gln Asn Asp Ser Arg Lys Gly Val Ile Gly 
            820                 825                 830         


Gly Leu Pro Ala Pro Glu Met Tyr Val Ile Asp Leu Met Phe His Pro 
        835                 840                 845             


Gly Gly Leu Met Lys Leu Arg Ser Arg Glu Ala Asp Leu Tyr Arg Phe 
    850                 855                 860                 


Ile 
865 


<210>  781
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC4__Homo_sapiens__NP_001276950

<400>  781

Met Arg Asp Phe Ser Leu Ala Gln Glu Thr Cys Gln Leu Ala Ile Arg 
1               5                   10                  15      


Asp Val Gly Gly Leu Glu Val Leu Ile Asn Leu Leu Glu Thr Asp Glu 
            20                  25                  30          


Val Lys Cys Lys Ile Gly Ser Leu Lys Ile Leu Lys Glu Ile Ser His 
        35                  40                  45              


Asn Pro Gln Ile Arg Gln Asn Ile Val Asp Leu Gly Gly Leu Pro Ile 
    50                  55                  60                  


Met Val Asn Ile Leu Asp Ser Pro His Lys Ser Leu Lys Cys Leu Ala 
65                  70                  75                  80  


Ala Glu Thr Ile Ala Asn Val Ala Lys Phe Lys Arg Ala Arg Arg Val 
                85                  90                  95      


Val Arg Gln His Gly Gly Ile Thr Lys Leu Val Ala Leu Leu Asp Cys 
            100                 105                 110         


Ala His Asp Ser Thr Lys Pro Ala Gln Ser Ser Leu Tyr Glu Ala Arg 
        115                 120                 125             


Asp Val Glu Val Ala Arg Cys Gly Ala Leu Ala Leu Trp Ser Cys Ser 
    130                 135                 140                 


Lys Ser His Thr Asn Lys Glu Ala Ile Arg Lys Ala Gly Gly Ile Pro 
145                 150                 155                 160 


Leu Leu Ala Arg Leu Leu Lys Thr Ser His Glu Asn Met Leu Ile Pro 
                165                 170                 175     


Val Val Gly Thr Leu Gln Glu Cys Ala Ser Glu Glu Asn Tyr Arg Ala 
            180                 185                 190         


Ala Ile Lys Ala Glu Arg Ile Ile Glu Asn Leu Val Lys Asn Leu Asn 
        195                 200                 205             


Ser Glu Asn Glu Gln Leu Gln Glu His Cys Ala Met Ala Ile Tyr Gln 
    210                 215                 220                 


Cys Ala Glu Asp Lys Glu Thr Arg Asp Leu Val Arg Leu His Gly Gly 
225                 230                 235                 240 


Leu Lys Pro Leu Ala Ser Leu Leu Asn Asn Thr Asp Asn Lys Glu Arg 
                245                 250                 255     


Leu Ala Ala Val Thr Gly Ala Ile Trp Lys Cys Ser Ile Ser Lys Glu 
            260                 265                 270         


Asn Val Thr Lys Phe Arg Glu Tyr Lys Ala Ile Glu Thr Leu Val Gly 
        275                 280                 285             


Leu Leu Thr Asp Gln Pro Glu Glu Val Leu Val Asn Val Val Gly Ala 
    290                 295                 300                 


Leu Gly Glu Cys Cys Gln Glu Arg Glu Asn Arg Val Ile Val Arg Lys 
305                 310                 315                 320 


Cys Gly Gly Ile Gln Pro Leu Val Asn Leu Leu Val Gly Ile Asn Gln 
                325                 330                 335     


Ala Leu Leu Val Asn Val Thr Lys Ala Val Gly Ala Cys Ala Val Glu 
            340                 345                 350         


Pro Glu Ser Met Met Ile Ile Asp Arg Leu Asp Gly Val Arg Leu Leu 
        355                 360                 365             


Trp Ser Leu Leu Lys Asn Pro His Pro Asp Val Lys Ala Ser Ala Ala 
    370                 375                 380                 


Trp Ala Leu Cys Pro Cys Ile Lys Asn Ala Lys Asp Ala Gly Glu Met 
385                 390                 395                 400 


Val Arg Ser Phe Val Gly Gly Leu Glu Leu Ile Val Asn Leu Leu Lys 
                405                 410                 415     


Ser Asp Asn Lys Glu Val Leu Ala Ser Val Cys Ala Ala Ile Thr Asn 
            420                 425                 430         


Ile Ala Lys Asp Gln Glu Asn Leu Ala Val Ile Thr Asp His Gly Val 
        435                 440                 445             


Val Pro Leu Leu Ser Lys Leu Ala Asn Thr Asn Asn Asn Lys Leu Arg 
    450                 455                 460                 


His His Leu Ala Glu Ala Ile Ser Arg Cys Cys Met Trp Gly Arg Asn 
465                 470                 475                 480 


Arg Val Ala Phe Gly Glu His Lys Ala Val Ala Pro Leu Val Arg Tyr 
                485                 490                 495     


Leu Lys Ser Asn Asp Thr Asn Val His Arg Ala Thr Ala Gln Ala Leu 
            500                 505                 510         


Tyr Gln Leu Ser Glu Asp Ala Asp Asn Cys Ile Thr Met His Glu Asn 
        515                 520                 525             


Gly Ala Val Lys Thr Glu Ser Arg His Val Ala Arg Leu Glu Cys Ser 
    530                 535                 540                 


Asp Asn Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys Arg 
545                 550                 555                 560 


Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr Ser Phe Tyr Trp 
                565                 570                 575     


Ile Trp Leu Gly Pro Leu Thr Arg Ile Ser Arg Lys Leu Gln Leu Val 
            580                 585                 590         


Val Tyr Pro Ile Ser Ala Gly Trp Leu Leu Leu Gln Arg Arg Gln Asp 
        595                 600                 605             


Thr Leu Glu Ile 
    610         


<210>  782
<211>  935
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC5__Homo_sapiens__NP_001098717

<400>  782

Met Ala Ala Ala Lys Pro Thr Leu Thr Asp Ser Leu Ser Phe Cys Leu 
1               5                   10                  15      


Ala Gln Leu Ala Ala Ala Ala Gly Glu Ala Leu Gly Gly Glu Lys Asp 
            20                  25                  30          


Pro Ala Thr Asn Glu Thr Pro Leu Ser Arg Ala Leu Leu Ala Leu Arg 
        35                  40                  45              


Thr Arg His Ile Lys Ala Ala Gly Gly Ile Glu Arg Phe Arg Ala Arg 
    50                  55                  60                  


Gly Gly Leu Arg Pro Leu Leu Ala Leu Leu Arg Arg Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Ser Ala Pro Ser Gln Ala Gly Pro Gly Ser Ala Pro Ser Ser Ala 
                85                  90                  95      


Ala Ser Gly Ala Ser Ser Pro Ala Pro Ala Ser Gly Pro Ala Pro Ser 
            100                 105                 110         


Ala Val Ser Ser Ser Ser Pro Thr Pro Pro Val Arg Leu Arg Lys Thr 
        115                 120                 125             


Leu Asp Leu Ala Leu Ser Ile Leu Ala Asp Cys Cys Thr Glu Gly Ala 
    130                 135                 140                 


Cys Arg Thr Glu Val Arg Arg Leu Gly Gly Ile Leu Pro Leu Val Thr 
145                 150                 155                 160 


Ile Leu Gln Cys Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg 
                165                 170                 175     


Ala Leu Gly Asn Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His 
            180                 185                 190         


Cys Ala Gly Ala Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln 
        195                 200                 205             


Asp Ser Gln Cys Leu Gln Ser Val Val Arg Ala Leu Arg Asn Leu Ala 
    210                 215                 220                 


Asp Ser Pro Gln His Arg Leu Ala Leu Ala Gln Gln Gly Ala Val Arg 
225                 230                 235                 240 


Pro Leu Ala Glu Leu Leu Ala Thr Ala Pro Asp Ala Ala Leu Thr Leu 
                245                 250                 255     


Ala Leu Val Arg Ala Leu Leu Glu Leu Ser Arg Gly Cys Ser Arg Ala 
            260                 265                 270         


Cys Ala Glu Gln Leu Ser Leu Gly Gly Gly Leu Gly Pro Leu Val Ser 
        275                 280                 285             


Leu Ala Ser His Pro Lys Arg Ala Val Arg Glu Gly Thr Ile Leu Ile 
    290                 295                 300                 


Leu Ala Asn Leu Cys Ala Gln Gly Leu Ile Arg Pro Ala Leu Gly Asn 
305                 310                 315                 320 


Ala Gly Gly Val Glu Val Leu Val Asp Glu Leu Arg Gln Arg Arg Asp 
                325                 330                 335     


Pro Asn Gly Ala Ser Pro Thr Ser Gln Gln Pro Leu Val Arg Ala Val 
            340                 345                 350         


Cys Leu Leu Cys Arg Glu Ala Ile Asn Arg Ala Arg Leu Arg Asp Ala 
        355                 360                 365             


Gly Gly Leu Asp Leu Leu Met Gly Leu Leu Arg Asp Pro Arg Ala Ser 
    370                 375                 380                 


Ala Trp His Pro Arg Ile Val Ala Ala Leu Val Gly Phe Leu Tyr Asp 
385                 390                 395                 400 


Thr Gly Ala Leu Gly Arg Leu Gln Ala Leu Gly Leu Val Pro Leu Leu 
                405                 410                 415     


Ala Gly Gln Leu Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg 
            420                 425                 430         


Glu Ala Ala Ser Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala 
        435                 440                 445             


Gln Gly Gly Ser Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly 
    450                 455                 460                 


Tyr Ala Thr Gly Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln 
465                 470                 475                 480 


Cys Pro Pro Glu Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr 
                485                 490                 495     


Ser Leu Arg Ala Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala 
            500                 505                 510         


Ala Ala Ile Glu Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu 
        515                 520                 525             


Leu Ser Arg Phe Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr 
    530                 535                 540                 


Gly Pro Ala Leu Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly 
545                 550                 555                 560 


Pro Pro Ser Pro Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn 
                565                 570                 575     


Pro Ala Cys Leu Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu 
            580                 585                 590         


Arg Ala Trp Leu Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro 
        595                 600                 605             


Arg Ala Arg Pro Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Arg 
    610                 615                 620                 


Leu Leu Gln Asn Leu Thr Val Gln Ala Glu Ser Pro Phe Gly Val Gly 
625                 630                 635                 640 


Ala Leu Thr His Leu Leu Leu Ser Gly Ser Pro Glu Asp Arg Val Ala 
                645                 650                 655     


Cys Ala Leu Thr Leu Pro Phe Ile Cys Arg Lys Pro Ser Leu Trp Arg 
            660                 665                 670         


Arg Leu Leu Leu Glu Gln Gly Gly Leu Arg Leu Leu Leu Ala Ala Leu 
        675                 680                 685             


Thr Arg Pro Ala Pro His Pro Leu Phe Leu Phe Phe Ala Ala Asp Ser 
    690                 695                 700                 


Leu Ser Cys Leu Gln Asp Leu Val Ser Pro Thr Val Ser Pro Ala Val 
705                 710                 715                 720 


Pro Gln Ala Val Pro Met Asp Leu Asp Ser Pro Ser Pro Cys Leu Tyr 
                725                 730                 735     


Glu Pro Leu Leu Gly Pro Ala Pro Val Pro Ala Pro Asp Leu His Phe 
            740                 745                 750         


Leu Leu Asp Ser Gly Leu Gln Leu Pro Ala Gln Arg Ala Ala Ser Ala 
        755                 760                 765             


Thr Ala Ser Pro Phe Phe Arg Ala Leu Leu Ser Gly Ser Phe Ala Glu 
    770                 775                 780                 


Ala Gln Met Asp Leu Val Pro Leu Arg Gly Leu Ser Pro Gly Ala Ala 
785                 790                 795                 800 


Trp Pro Val Leu His His Leu His Gly Cys Arg Gly Cys Gly Ala Ala 
                805                 810                 815     


Leu Gly Pro Val Pro Pro Pro Gly Gln Pro Leu Leu Gly Ser Glu Ala 
            820                 825                 830         


Glu Glu Ala Leu Glu Ala Ala Gly Arg Phe Leu Leu Pro Gly Leu Glu 
        835                 840                 845             


Glu Glu Leu Glu Glu Ala Val Gly Arg Ile His Leu Gly Pro Gln Gly 
    850                 855                 860                 


Gly Pro Glu Ser Val Gly Glu Val Phe Arg Leu Gly Arg Pro Arg Leu 
865                 870                 875                 880 


Ala Ala His Cys Ala Arg Trp Thr Leu Gly Ser Glu Gln Cys Pro Arg 
                885                 890                 895     


Lys Arg Gly Leu Ala Leu Val Gly Leu Val Glu Ala Ala Gly Glu Glu 
            900                 905                 910         


Ala Gly Pro Leu Thr Glu Ala Leu Leu Ala Val Val Met Gly Ile Glu 
        915                 920                 925             


Leu Gly Ala Arg Val Pro Ala 
    930                 935 


<210>  783
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC8__Homo_sapiens__NP_001253970

<400>  783

Met Ala Cys Leu Leu Glu Thr Pro Ile Arg Met Ser Val Leu Ser Glu 
1               5                   10                  15      


Val Thr Ala Ser Ser Arg His Tyr Val Asp Arg Leu Phe Asp Pro Asp 
            20                  25                  30          


Pro Gln Lys Val Leu Gln Gly Val Ile Asp Met Lys Asn Ala Val Ile 
        35                  40                  45              


Gly Asn Asn Lys Gln Lys Ala Asn Leu Ile Val Leu Gly Ala Val Pro 
    50                  55                  60                  


Arg Leu Leu Tyr Leu Leu Gln Gln Glu Thr Ser Ser Thr Glu Leu Lys 
65                  70                  75                  80  


Thr Glu Cys Ala Val Val Leu Gly Ser Leu Ala Met Gly Thr Glu Asn 
                85                  90                  95      


Asn Val Lys Ser Leu Leu Asp Cys His Ile Ile Pro Ala Leu Leu Gln 
            100                 105                 110         


Gly Leu Leu Ser Pro Asp Leu Lys Phe Ile Glu Ala Cys Leu Arg Cys 
        115                 120                 125             


Leu Arg Thr Ile Phe Thr Ser Pro Val Thr Pro Glu Glu Leu Leu Tyr 
    130                 135                 140                 


Thr Gly Pro Asp His Gln Thr Ile Leu Phe Asn His Gly Ala Val Gln 
145                 150                 155                 160 


Asn Ile Ala His Leu Leu Thr Ser Leu Ser Tyr Lys Val Arg Met Gln 
                165                 170                 175     


Ala Leu Lys Cys Phe Ser Val Leu Ala Phe Glu Asn Pro Gln Val Ser 
            180                 185                 190         


Met Thr Leu Val Asn Val Leu Val Asp Gly Glu Leu Leu Pro Gln Ile 
        195                 200                 205             


Phe Val Lys Met Leu Gln Arg Asp Lys Pro Ile Glu Met Gln Leu Thr 
    210                 215                 220                 


Ser Ala Lys Cys Leu Thr Tyr Met Cys Arg Ala Gly Ala Ile Arg Thr 
225                 230                 235                 240 


Asp Asp Asn Cys Ile Val Leu Lys Thr Leu Pro Cys Leu Val Arg Met 
                245                 250                 255     


Cys Ser Lys Glu Arg Leu Leu Glu Glu Arg Val Glu Gly Ala Glu Thr 
            260                 265                 270         


Leu Ala Tyr Leu Ile Glu Pro Asp Val Glu Leu Gln Arg Ile Ala Ser 
        275                 280                 285             


Ile Thr Asp His Leu Ile Ala Met Leu Ala Asp Tyr Phe Lys Tyr Pro 
    290                 295                 300                 


Ser Ser Val Ser Ala Ile Thr Asp Ile Lys Arg Leu Asp His Asp Leu 
305                 310                 315                 320 


Lys His Ala His Glu Leu Arg Gln Ala Ala Phe Lys Leu Tyr Ala Ser 
                325                 330                 335     


Leu Gly Ala Asn Asp Glu Asp Ile Arg Lys Lys Ile Ile Glu Thr Glu 
            340                 345                 350         


Asn Met Met Asp Arg Ile Val Thr Gly Leu Ser Glu Ser Ser Val Lys 
        355                 360                 365             


Val Arg Leu Ala Ala Val Arg Cys Leu His Ser Leu Ser Arg Ser Val 
    370                 375                 380                 


Gln Gln Leu Arg Thr Ser Phe Gln Asp His Ala Val Trp Lys Pro Leu 
385                 390                 395                 400 


Met Lys Val Leu Gln Asn Ala Pro Asp Glu Ile Leu Val Val Ala Ser 
                405                 410                 415     


Ser Met Leu Cys Asn Leu Leu Leu Glu Phe Ser Pro Ser Lys Glu Pro 
            420                 425                 430         


Ile Leu Glu Ser Gly Ala Val Glu Leu Leu Cys Gly Leu Thr Gln Ser 
        435                 440                 445             


Glu Asn Pro Ala Leu Arg Val Asn Gly Ile Trp Ala Leu Met Asn Met 
    450                 455                 460                 


Ala Phe Gln Ala Glu Gln Lys Ile Lys Ala Asp Ile Leu Arg Ser Leu 
465                 470                 475                 480 


Ser Thr Glu Gln Leu Phe Arg Leu Leu Ser Asp Ser Asp Leu Asn Val 
                485                 490                 495     


Leu Met Lys Thr Leu Gly Leu Leu Arg Asn Leu Leu Ser Thr Arg Pro 
            500                 505                 510         


His Ile Asp Lys Ile Met Ser Thr His Gly Lys Gln Ile Met Gln Ala 
        515                 520                 525             


Val Thr Leu Ile Leu Glu Gly Glu His Asn Ile Glu Val Lys Glu Gln 
    530                 535                 540                 


Thr Leu Cys Ile Leu Ala Asn Ile Ala Asp Gly Thr Thr Ala Lys Asp 
545                 550                 555                 560 


Leu Ile Met Thr Asn Asp Asp Ile Leu Gln Lys Ile Lys Tyr Tyr Met 
                565                 570                 575     


Gly His Ser His Val Lys Leu Gln Leu Ala Ala Met Phe Cys Ile Ser 
            580                 585                 590         


Asn Leu Ile Trp Asn Glu Glu Glu Gly Ser Gln Glu Arg Gln Asp Lys 
        595                 600                 605             


Leu Arg Asp Met Gly Ile Val Asp Ile Leu His Lys Leu Ser Gln Ser 
    610                 615                 620                 


Pro Asp Ser Asn Leu Cys Asp Lys Ala Lys Met Ala Leu Gln Gln Tyr 
625                 630                 635                 640 


Leu Ala 
        


<210>  784
<211>  818
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMC9__Homo_sapiens__NP_001258395

<400>  784

Met Gly Asp Ile Leu Ala His Glu Ser Glu Leu Leu Gly Leu Val Lys 
1               5                   10                  15      


Glu Tyr Leu Asp Phe Ala Glu Phe Glu Asp Thr Leu Lys Thr Phe Ser 
            20                  25                  30          


Lys Glu Cys Lys Ile Lys Gly Lys Pro Leu Cys Lys Thr Val Gly Gly 
        35                  40                  45              


Ser Phe Arg Asp Ser Lys Ser Leu Thr Ile Gln Lys Asp Leu Val Ala 
    50                  55                  60                  


Ala Phe Asp Asn Gly Asp Gln Lys Val Phe Phe Asp Leu Trp Glu Glu 
65                  70                  75                  80  


His Ile Ser Ser Ser Ile Arg Asp Gly Asp Ser Phe Ala Gln Lys Leu 
                85                  90                  95      


Glu Phe Tyr Leu His Ile His Phe Ala Ile Tyr Leu Leu Lys Tyr Ser 
            100                 105                 110         


Val Gly Arg Pro Asp Lys Glu Glu Leu Asp Glu Lys Ile Ser Tyr Phe 
        115                 120                 125             


Lys Thr Tyr Leu Glu Thr Lys Gly Ala Ala Leu Ser Gln Thr Thr Glu 
    130                 135                 140                 


Phe Leu Pro Phe Tyr Ala Leu Pro Phe Val Pro Asn Pro Met Val His 
145                 150                 155                 160 


Pro Ser Phe Lys Glu Leu Phe Gln Asp Ser Trp Thr Pro Glu Leu Lys 
                165                 170                 175     


Leu Lys Leu Glu Lys Phe Leu Ala Leu Ile Ser Lys Ala Ser Asn Thr 
            180                 185                 190         


Pro Lys Leu Leu Thr Ile Tyr Lys Glu Asn Gly Gln Ser Asn Lys Glu 
        195                 200                 205             


Ile Leu Gln Gln Leu His Gln Gln Leu Val Glu Ala Glu Arg Arg Ser 
    210                 215                 220                 


Val Thr Tyr Leu Lys Arg Tyr Asn Lys Ile Gln Ala Asp Tyr His Asn 
225                 230                 235                 240 


Leu Ile Gly Val Thr Ala Glu Leu Val Asp Ser Leu Glu Ala Thr Val 
                245                 250                 255     


Ser Gly Lys Met Ile Thr Pro Glu Tyr Leu Gln Ser Val Cys Val Arg 
            260                 265                 270         


Leu Phe Ser Asn Gln Met Arg Gln Ser Leu Ala His Ser Val Asp Phe 
        275                 280                 285             


Thr Arg Pro Gly Thr Ala Ser Thr Met Leu Arg Ala Ser Leu Ala Pro 
    290                 295                 300                 


Val Lys Leu Lys Asp Val Pro Leu Leu Pro Ser Leu Asp Tyr Glu Lys 
305                 310                 315                 320 


Leu Lys Lys Asp Leu Ile Leu Gly Ser Asp Arg Leu Lys Ala Phe Leu 
                325                 330                 335     


Leu Gln Ala Leu Arg Trp Arg Leu Thr Thr Ser His Pro Gly Glu Gln 
            340                 345                 350         


Arg Glu Thr Val Leu Gln Ala Tyr Ile Ser Asn Asp Leu Leu Asp Cys 
        355                 360                 365             


Tyr Ser His Asn Gln Arg Ser Val Leu Gln Leu Leu His Ser Thr Ser 
    370                 375                 380                 


Asp Val Val Arg Gln Tyr Met Ala Arg Leu Ile Asn Ala Phe Ala Ser 
385                 390                 395                 400 


Leu Ala Glu Gly Arg Leu Tyr Leu Ala Gln Asn Thr Lys Val Leu Gln 
                405                 410                 415     


Met Leu Glu Gly Arg Leu Lys Glu Glu Asp Lys Asp Ile Ile Thr Arg 
            420                 425                 430         


Glu Asn Val Leu Gly Ala Leu Gln Lys Phe Ser Leu Arg Arg Pro Leu 
        435                 440                 445             


Gln Thr Ala Met Ile Gln Asp Gly Leu Ile Phe Trp Leu Val Asp Val 
    450                 455                 460                 


Leu Lys Asp Pro Asp Cys Leu Ser Asp Tyr Thr Leu Glu Tyr Ser Val 
465                 470                 475                 480 


Ala Leu Leu Met Asn Leu Cys Leu Arg Ser Thr Gly Lys Asn Met Cys 
                485                 490                 495     


Ala Lys Val Ala Gly Leu Val Leu Lys Val Leu Ser Asp Leu Leu Gly 
            500                 505                 510         


His Glu Asn His Glu Ile Gln Pro Tyr Val Asn Gly Ala Leu Tyr Ser 
        515                 520                 525             


Ile Leu Ser Val Pro Ser Ile Arg Glu Glu Ala Arg Ala Met Gly Met 
    530                 535                 540                 


Glu Asp Ile Leu Arg Cys Phe Ile Lys Glu Gly Asn Ala Glu Met Ile 
545                 550                 555                 560 


Arg Gln Ile Glu Phe Ile Ile Lys Gln Leu Asn Ser Glu Glu Leu Pro 
                565                 570                 575     


Asp Gly Val Leu Glu Ser Asp Asp Asp Glu Asp Glu Asp Asp Glu Glu 
            580                 585                 590         


Asp His Asp Ile Met Glu Ala Asp Leu Asp Lys Asp Glu Leu Ile Gln 
        595                 600                 605             


Pro Gln Leu Gly Glu Leu Ser Gly Glu Lys Leu Leu Thr Thr Glu Tyr 
    610                 615                 620                 


Leu Gly Ile Met Thr Asn Thr Gly Lys Thr Arg Arg Lys Gly Leu Ala 
625                 630                 635                 640 


Asn Val Gln Trp Ser Gly Asp Glu Pro Leu Gln Arg Pro Val Thr Pro 
                645                 650                 655     


Gly Gly His Arg Asn Gly Tyr Pro Val Val Glu Asp Gln His Thr Pro 
            660                 665                 670         


Pro Gln Thr Ala Gln His Ala Arg Asn Gly His Pro Gln Ala Leu Pro 
        675                 680                 685             


Ala Ala His Glu Ala Val Tyr Arg Glu Gly Lys Pro Ser Thr Pro Glu 
    690                 695                 700                 


Ser Cys Val Ser Ser Ser Ser Ala Ile Ile Ala Lys Pro Gly Glu Trp 
705                 710                 715                 720 


Leu Pro Arg Gly Arg Gln Glu Glu Pro Arg Pro Ala Pro Thr Gly Thr 
                725                 730                 735     


Pro Arg Gln Pro Arg Glu Ala Pro Gln Asp Pro Gly Asn Gly Val Thr 
            740                 745                 750         


Thr Arg Glu Cys Ala Ser Ala Phe Thr Cys Lys Pro Arg Ala Pro Cys 
        755                 760                 765             


Thr Pro Glu Met Leu Asp Trp Asn Pro Pro Lys Ala Lys Ala Ser Val 
    770                 775                 780                 


Leu Ala Pro Leu Phe Ser Ser Cys Gly Pro Gln Gln Ala Ser Arg Pro 
785                 790                 795                 800 


Gly Ser Thr Ala Ser Ser Thr Arg Gly Leu Pro Ser Ser Gln Ser His 
                805                 810                 815     


Arg Lys 
        


<210>  785
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMCX1__Homo_sapiens__NP_057692

<400>  785

Met Gly Arg Thr Arg Glu Ala Gly Cys Val Ala Ala Gly Val Val Ile 
1               5                   10                  15      


Gly Ala Gly Ala Cys Tyr Cys Val Tyr Arg Leu Ala Trp Gly Arg Asp 
            20                  25                  30          


Glu Asn Glu Lys Ile Trp Asp Glu Asp Glu Glu Ser Thr Asp Thr Ser 
        35                  40                  45              


Glu Ile Gly Val Glu Thr Val Lys Gly Ala Lys Thr Asn Ala Gly Ala 
    50                  55                  60                  


Gly Ser Gly Ala Lys Leu Gln Gly Asp Ser Glu Val Lys Pro Glu Val 
65                  70                  75                  80  


Ser Leu Gly Leu Glu Asp Cys Pro Gly Val Lys Glu Lys Ala His Ser 
                85                  90                  95      


Gly Ser His Ser Gly Gly Gly Leu Glu Ala Lys Ala Lys Ala Leu Phe 
            100                 105                 110         


Asn Thr Leu Lys Glu Gln Ala Ser Ala Lys Ala Gly Lys Gly Ala Arg 
        115                 120                 125             


Val Gly Thr Ile Ser Gly Asn Arg Thr Leu Ala Pro Ser Leu Pro Cys 
    130                 135                 140                 


Pro Gly Gly Arg Gly Gly Gly Cys His Pro Thr Arg Ser Gly Ser Arg 
145                 150                 155                 160 


Ala Gly Gly Arg Ala Ser Gly Lys Ser Lys Gly Lys Ala Arg Ser Lys 
                165                 170                 175     


Ser Thr Arg Ala Pro Ala Thr Thr Trp Pro Val Arg Arg Gly Lys Phe 
            180                 185                 190         


Asn Phe Pro Tyr Lys Ile Asp Asp Ile Leu Ser Ala Pro Asp Leu Gln 
        195                 200                 205             


Lys Val Leu Asn Ile Leu Glu Arg Thr Asn Asp Pro Phe Ile Gln Glu 
    210                 215                 220                 


Val Ala Leu Val Thr Leu Gly Asn Asn Ala Ala Tyr Ser Phe Asn Gln 
225                 230                 235                 240 


Asn Ala Ile Arg Glu Leu Gly Gly Val Pro Ile Ile Ala Lys Leu Ile 
                245                 250                 255     


Lys Thr Lys Asp Pro Ile Ile Arg Glu Lys Thr Tyr Asn Ala Leu Asn 
            260                 265                 270         


Asn Leu Ser Val Asn Ala Glu Asn Gln Gly Lys Ile Lys Thr Tyr Ile 
        275                 280                 285             


Ser Gln Val Cys Asp Asp Thr Met Val Cys Arg Leu Asp Ser Ala Val 
    290                 295                 300                 


Gln Met Ala Gly Leu Arg Leu Leu Thr Asn Met Thr Val Thr Asn His 
305                 310                 315                 320 


Tyr Gln His Leu Leu Ser Tyr Ser Phe Pro Asp Phe Phe Ala Leu Leu 
                325                 330                 335     


Phe Leu Gly Asn His Phe Thr Lys Ile Gln Ile Met Lys Leu Ile Ile 
            340                 345                 350         


Asn Phe Thr Glu Asn Pro Ala Met Thr Arg Glu Leu Val Ser Cys Lys 
        355                 360                 365             


Val Pro Ser Glu Leu Ile Ser Leu Phe Asn Lys Glu Trp Asp Arg Glu 
    370                 375                 380                 


Ile Leu Leu Asn Ile Leu Thr Leu Phe Glu Asn Ile Asn Asp Asn Ile 
385                 390                 395                 400 


Lys Asn Glu Gly Leu Ala Ser Ser Arg Lys Glu Phe Ser Arg Ser Ser 
                405                 410                 415     


Leu Phe Phe Leu Phe Lys Glu Ser Gly Val Cys Val Lys Lys Ile Lys 
            420                 425                 430         


Ala Leu Ala Asn His Asn Asp Leu Val Val Lys Val Lys Val Leu Lys 
        435                 440                 445             


Val Leu Thr Lys Leu 
    450             


<210>  786
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMS2__Homo_sapiens__NP_001093137

<400>  786

Met Leu Arg Leu Tyr Pro Gly Pro Met Val Thr Glu Ala Glu Gly Lys 
1               5                   10                  15      


Gly Gly Pro Glu Met Ala Ser Leu Ser Ser Ser Val Val Pro Val Ser 
            20                  25                  30          


Phe Ile Ser Thr Leu Arg Glu Ser Val Leu Asp Pro Gly Val Gly Gly 
        35                  40                  45              


Glu Gly Ala Ser Asp Lys Gln Arg Ser Lys Leu Ser Leu Ser His Ser 
    50                  55                  60                  


Met Ile Pro Ala Ala Lys Ile His Thr Glu Leu Cys Leu Pro Ala Phe 
65                  70                  75                  80  


Phe Ser Pro Ala Gly Thr Gln Arg Arg Phe Gln Gln Pro Gln His His 
                85                  90                  95      


Leu Thr Leu Ser Ile Ile His Thr Ala Ala Arg 
            100                 105         


<210>  787
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARMT1__Homo_sapiens__NP_001273491

<400>  787

Met Tyr Arg Arg Ile His Glu Ala Ile Ile Gln Ser Pro Pro Ile Asp 
1               5                   10                  15      


Tyr Phe Asp Val Phe Lys Glu Ser Lys Glu Gln Asn Phe Tyr Gly Ser 
            20                  25                  30          


Gln Glu Ser Ile Ile Ala Leu Cys Thr His Leu Gln Gln Leu Ile Arg 
        35                  40                  45              


Thr Ile Glu Asp Leu Asp Glu Asn Gln Leu Lys Asp Glu Phe Phe Lys 
    50                  55                  60                  


Leu Leu Gln Ile Ser Leu Trp Gly Asn Lys Cys Asp Leu Ser Leu Ser 
65                  70                  75                  80  


Gly Gly Glu Ser Ser Ser Gln Asn Thr Asn Val Leu Asn Ser Leu Glu 
                85                  90                  95      


Asp Leu Lys Pro Phe Ile Leu Leu Asn Asp Met Glu His Leu Trp Ser 
            100                 105                 110         


Leu Leu Ser Asn Cys Lys Lys Thr Arg Glu Lys Ala Ser Ala Thr Arg 
        115                 120                 125             


Val Tyr Ile Val Leu Asp Asn Ser Gly Phe Glu Leu Val Thr Asp Leu 
    130                 135                 140                 


Ile Leu Ala Asp Phe Leu Leu Ser Ser Glu Leu Ala Thr Glu Val His 
145                 150                 155                 160 


Phe Tyr Gly Lys Thr Ile Pro Trp Phe Val Ser Asp Thr Thr Ile His 
                165                 170                 175     


Asp Phe Asn Trp Leu Ile Glu Gln Val Lys His Ser Asn His Lys Trp 
            180                 185                 190         


Met Ser Lys Cys Gly Ala Asp Trp Glu Glu Tyr Ile Lys Met Gly Lys 
        195                 200                 205             


Trp Val Tyr His Asn His Ile Phe Trp Thr Leu Pro His Glu Tyr Cys 
    210                 215                 220                 


Ala Met Pro Gln Val Ala Pro Asp Leu Tyr Ala Glu Leu Gln Lys Ala 
225                 230                 235                 240 


His Leu Ile Leu Phe Lys Gly Asp Leu Asn Tyr Arg Lys Leu Thr Gly 
                245                 250                 255     


Asp Arg Lys Trp Glu Phe Ser Val Pro Phe His Gln Ala Leu Asn Gly 
            260                 265                 270         


Phe His Pro Ala Pro Leu Cys Thr Ile Arg Thr Leu Lys Ala Glu Ile 
        275                 280                 285             


Gln Val Gly Leu Gln Pro Gly Gln Gly Glu Gln Leu Leu Ala Ser Glu 
    290                 295                 300                 


Pro Ser Trp Trp Thr Thr Gly Lys Tyr Gly Ile Phe Gln Tyr Asp Gly 
305                 310                 315                 320 


Pro Leu 
        


<210>  788
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARNT2__Homo_sapiens__NP_055677

<400>  788

Met Ala Thr Pro Ala Ala Val Asn Pro Pro Glu Met Ala Ser Asp Ile 
1               5                   10                  15      


Pro Gly Ser Val Thr Leu Pro Val Ala Pro Met Ala Ala Thr Gly Gln 
            20                  25                  30          


Val Arg Met Ala Gly Ala Met Pro Ala Arg Gly Gly Lys Arg Arg Ser 
        35                  40                  45              


Gly Met Asp Phe Asp Asp Glu Asp Gly Glu Gly Pro Ser Lys Phe Ser 
    50                  55                  60                  


Arg Glu Asn His Ser Glu Ile Glu Arg Arg Arg Arg Asn Lys Met Thr 
65                  70                  75                  80  


Gln Tyr Ile Thr Glu Leu Ser Asp Met Val Pro Thr Cys Ser Ala Leu 
                85                  90                  95      


Ala Arg Lys Pro Asp Lys Leu Thr Ile Leu Arg Met Ala Val Ser His 
            100                 105                 110         


Met Lys Ser Met Arg Gly Thr Gly Asn Lys Ser Thr Asp Gly Ala Tyr 
        115                 120                 125             


Lys Pro Ser Phe Leu Thr Glu Gln Glu Leu Lys His Leu Ile Leu Glu 
    130                 135                 140                 


Ala Ala Asp Gly Phe Leu Phe Val Val Ala Ala Glu Thr Gly Arg Val 
145                 150                 155                 160 


Ile Tyr Val Ser Asp Ser Val Thr Pro Val Leu Asn Gln Pro Gln Ser 
                165                 170                 175     


Glu Trp Phe Gly Ser Thr Leu Tyr Glu Gln Val His Pro Asp Asp Val 
            180                 185                 190         


Glu Lys Leu Arg Glu Gln Leu Cys Thr Ser Glu Asn Ser Met Thr Gly 
        195                 200                 205             


Arg Ile Leu Asp Leu Lys Thr Gly Thr Val Lys Lys Glu Gly Gln Gln 
    210                 215                 220                 


Ser Ser Met Arg Met Cys Met Gly Ser Arg Arg Ser Phe Ile Cys Arg 
225                 230                 235                 240 


Met Arg Cys Gly Asn Ala Pro Leu Asp His Leu Pro Leu Asn Arg Ile 
                245                 250                 255     


Thr Thr Met Arg Lys Arg Phe Arg Asn Gly Leu Gly Pro Val Lys Glu 
            260                 265                 270         


Gly Glu Ala Gln Tyr Ala Val Val His Cys Thr Gly Tyr Ile Lys Ala 
        275                 280                 285             


Trp Pro Pro Ala Gly Met Thr Ile Pro Glu Glu Asp Ala Asp Val Gly 
    290                 295                 300                 


Gln Gly Ser Lys Tyr Cys Leu Val Ala Ile Gly Arg Leu Gln Val Thr 
305                 310                 315                 320 


Ser Ser Pro Val Cys Met Asp Met Asn Gly Met Ser Val Pro Thr Glu 
                325                 330                 335     


Phe Leu Ser Arg His Asn Ser Asp Gly Ile Ile Thr Phe Val Asp Pro 
            340                 345                 350         


Arg Cys Ile Ser Val Ile Gly Tyr Gln Pro Gln Asp Leu Leu Gly Lys 
        355                 360                 365             


Asp Ile Leu Glu Phe Cys His Pro Glu Asp Gln Ser His Leu Arg Glu 
    370                 375                 380                 


Ser Phe Gln Gln Val Val Lys Leu Lys Gly Gln Val Leu Ser Val Met 
385                 390                 395                 400 


Tyr Arg Phe Arg Thr Lys Asn Arg Glu Trp Met Leu Ile Arg Thr Ser 
                405                 410                 415     


Ser Phe Thr Phe Gln Asn Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile 
            420                 425                 430         


Cys Thr Asn Thr Asn Val Lys Gln Leu Gln Gln Gln Gln Ala Glu Leu 
        435                 440                 445             


Glu Val His Gln Arg Asp Gly Leu Ser Ser Tyr Asp Leu Ser Gln Val 
    450                 455                 460                 


Pro Val Pro Asn Leu Pro Ala Gly Val His Glu Ala Gly Lys Ser Val 
465                 470                 475                 480 


Glu Lys Ala Asp Ala Ile Phe Ser Gln Glu Arg Asp Pro Arg Phe Ala 
                485                 490                 495     


Glu Met Phe Ala Gly Ile Ser Ala Ser Glu Lys Lys Met Met Ser Ser 
            500                 505                 510         


Ala Ser Ala Ala Gly Thr Gln Gln Ile Tyr Ser Gln Gly Ser Pro Phe 
        515                 520                 525             


Pro Ser Gly His Ser Gly Lys Ala Phe Ser Ser Ser Val Val His Val 
    530                 535                 540                 


Pro Gly Val Asn Asp Ile Gln Ser Ser Ser Ser Thr Gly Gln Asn Met 
545                 550                 555                 560 


Ser Gln Ile Ser Arg Gln Leu Asn Gln Ser Gln Val Ala Trp Thr Gly 
                565                 570                 575     


Ser Arg Pro Pro Phe Pro Gly Gln Gln Ile Pro Ser Gln Ser Ser Lys 
            580                 585                 590         


Thr Gln Ser Ser Pro Phe Gly Ile Gly Thr Ser His Thr Tyr Pro Ala 
        595                 600                 605             


Asp Pro Ser Ser Tyr Ser Pro Leu Ser Ser Pro Ala Thr Ser Ser Pro 
    610                 615                 620                 


Ser Gly Asn Ala Tyr Ser Ser Leu Ala Asn Arg Thr Pro Gly Phe Ala 
625                 630                 635                 640 


Glu Ser Gly Gln Ser Ser Gly Gln Phe Gln Gly Arg Pro Ser Glu Val 
                645                 650                 655     


Trp Ser Gln Trp Gln Ser Gln His His Gly Gln Gln Ser Gly Glu Gln 
            660                 665                 670         


His Ser His Gln Gln Pro Gly Gln Thr Glu Val Phe Gln Asp Met Leu 
        675                 680                 685             


Pro Met Pro Gly Asp Pro Thr Gln Gly Thr Gly Asn Tyr Asn Ile Glu 
    690                 695                 700                 


Asp Phe Ala Asp Leu Gly Met Phe Pro Pro Phe Ser Glu 
705                 710                 715         


<210>  789
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARNT__Homo_sapiens__XP_011507849

<400>  789

Met Tyr His His Trp Val Gln Pro Leu Pro Leu Glu Thr Leu Asp Leu 
1               5                   10                  15      


Glu Phe Lys Val Glu Glu Pro Leu Ser Arg Gly Leu Leu Ser Gly Asp 
            20                  25                  30          


Gln Ala Gly Leu Lys Tyr Leu Leu Leu Ala Phe Leu Arg Leu Asp Phe 
        35                  40                  45              


Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp Asp 
    50                  55                  60                  


Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Glu Asn His Ser Glu 
65                  70                  75                  80  


Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
                85                  90                  95      


Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
            100                 105                 110         


Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
        115                 120                 125             


Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
    130                 135                 140                 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
145                 150                 155                 160 


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
                165                 170                 175     


Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
            180                 185                 190         


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
        195                 200                 205             


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
    210                 215                 220                 


Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
225                 230                 235                 240 


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
                245                 250                 255     


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
            260                 265                 270         


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
        275                 280                 285             


Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
    290                 295                 300                 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
305                 310                 315                 320 


Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr 
                325                 330                 335     


Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn 
            340                 345                 350         


Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val 
        355                 360                 365             


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
    370                 375                 380                 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
385                 390                 395                 400 


Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
                405                 410                 415     


Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn 
            420                 425                 430         


Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn Val 
        435                 440                 445             


Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln 
    450                 455                 460                 


Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly Ser 
465                 470                 475                 480 


Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp Met 
                485                 490                 495     


Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
            500                 505                 510         


Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
        515                 520                 525             


Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
    530                 535                 540                 


Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Thr 
545                 550                 555                 560 


Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro Pro 
                565                 570                 575     


Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro 
            580                 585                 590         


Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln 
        595                 600                 605             


Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp Thr 
    610                 615                 620                 


Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Val Ala Thr Gln Ala Thr 
625                 630                 635                 640 


Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln Thr Pro 
                645                 650                 655     


Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala Ser Pro 
            660                 665                 670         


Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn Phe Ala 
        675                 680                 685             


Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr Ala Glu 
    690                 695                 700                 


Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His Arg 
705                 710                 715                 720 


Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln Pro 
                725                 730                 735     


Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp Gln 
            740                 745                 750         


Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe Pro 
        755                 760                 765             


Pro Phe Ser Glu 
    770         


<210>  790
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARNTL2__Homo_sapiens__NP_001234931

<400>  790

Met Ala Ala Glu Glu Glu Ala Ala Ala Gly Gly Lys Val Leu Arg Glu 
1               5                   10                  15      


Glu Asn Gln Cys Ile Ala Pro Val Val Ser Ser Arg Val Ser Pro Gly 
            20                  25                  30          


Thr Arg Pro Thr Ala Met Gly Ser Phe Ser Ser His Met Thr Glu Phe 
        35                  40                  45              


Pro Arg Lys Arg Lys Gly Ser Asp Ser Asp Pro Ser Gln Ser Gly Ile 
    50                  55                  60                  


Met Thr Glu Lys Val Val Glu Lys Leu Ser Gln Asn Pro Leu Thr Tyr 
65                  70                  75                  80  


Leu Leu Ser Thr Arg Ile Glu Ile Ser Ala Ser Ser Gly Ser Arg Glu 
                85                  90                  95      


Ala His Ser Gln Thr Glu Lys Arg Arg Arg Asp Lys Met Asn Asn Leu 
            100                 105                 110         


Ile Glu Glu Leu Ser Ala Met Ile Pro Gln Cys Asn Pro Met Ala Arg 
        115                 120                 125             


Lys Leu Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His Leu Arg 
    130                 135                 140                 


Ser Leu Lys Gly Leu Thr Asn Ser Tyr Val Gly Ser Asn Tyr Arg Pro 
145                 150                 155                 160 


Ser Phe Leu Gln Asp Asn Glu Leu Arg His Leu Ile Leu Lys Thr Ala 
                165                 170                 175     


Glu Gly Phe Leu Phe Val Val Gly Cys Glu Arg Gly Lys Ile Leu Phe 
            180                 185                 190         


Val Ser Lys Ser Val Ser Lys Ile Leu Asn Tyr Asp Gln Ala Ser Leu 
        195                 200                 205             


Thr Gly Gln Ser Leu Phe Asp Phe Leu His Pro Lys Asp Val Ala Lys 
    210                 215                 220                 


Val Lys Glu Gln Leu Ser Ser Phe Asp Ile Ser Pro Arg Glu Lys Leu 
225                 230                 235                 240 


Ile Asp Ala Lys Thr Gly Leu Gln Val His Ser Asn Leu His Ala Gly 
                245                 250                 255     


Arg Thr Arg Val Tyr Ser Gly Ser Arg Arg Ser Phe Phe Cys Arg Ile 
            260                 265                 270         


Lys Ser Cys Lys Ile Ser Val Lys Glu Glu His Gly Cys Leu Pro Asn 
        275                 280                 285             


Ser Lys Lys Lys Glu His Arg Lys Phe Tyr Thr Ile His Cys Thr Gly 
    290                 295                 300                 


Tyr Leu Arg Ser Trp Pro Pro Asn Ile Val Gly Met Glu Glu Glu Arg 
305                 310                 315                 320 


Asn Ser Lys Lys Asp Asn Ser Asn Phe Thr Cys Leu Val Ala Ile Gly 
                325                 330                 335     


Arg Leu Gln Pro Tyr Ile Val Pro Gln Asn Ser Gly Glu Ile Asn Val 
            340                 345                 350         


Lys Pro Thr Glu Phe Ile Thr Arg Phe Ala Val Asn Gly Lys Phe Val 
        355                 360                 365             


Tyr Val Asp Gln Arg Ala Thr Ala Ile Leu Gly Tyr Leu Pro Gln Glu 
    370                 375                 380                 


Leu Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp His Asn 
385                 390                 395                 400 


Asn Leu Thr Asp Lys His Lys Ala Val Leu Gln Ser Lys Glu Lys Ile 
                405                 410                 415     


Leu Thr Asp Ser Tyr Lys Phe Arg Ala Lys Asp Gly Ser Phe Val Thr 
            420                 425                 430         


Leu Lys Ser Gln Trp Phe Ser Phe Thr Asn Pro Trp Thr Lys Glu Leu 
        435                 440                 445             


Glu Tyr Ile Val Ser Val Asn Thr Leu Val Leu Gly His Ser Glu Pro 
    450                 455                 460                 


Gly Glu Ala Ser Phe Leu Pro Cys Ser Ser Gln Ser Ser Glu Glu Ser 
465                 470                 475                 480 


Ser Arg Gln Ser Cys Met Ser Val Pro Gly Met Ser Thr Gly Thr Val 
                485                 490                 495     


Leu Gly Ala Gly Ser Ile Gly Thr Asp Ile Ala Asn Glu Ile Leu Asp 
            500                 505                 510         


Leu Gln Arg Leu Gln Ser Ser Ser Tyr Leu Asp Asp Ser Ser Pro Thr 
        515                 520                 525             


Gly Leu Met Lys Asp Thr His Thr Val Asn Cys Arg Ser Met Ser Asn 
    530                 535                 540                 


Lys Glu Leu Phe Pro Pro Ser Pro Ser Glu Met Gly Glu Leu Glu Ala 
545                 550                 555                 560 


Thr Arg Gln Asn Gln Ser Thr Val Ala Val His Ser His Glu Pro Leu 
                565                 570                 575     


Leu Ser Asp Gly Ala Gln Leu Asp Phe Asp Ala Leu Cys Asp Asn Asp 
            580                 585                 590         


Asp Thr Ala Met Ala Ala Phe Met Asn Tyr Leu Glu Ala Glu Gly Gly 
        595                 600                 605             


Leu Gly Asp Pro Gly Asp Phe Ser Asp Ile Gln Trp Thr Leu 
    610                 615                 620         


<210>  791
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARNTL__Homo_sapiens__NP_001025443

<400>  791

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Thr 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Thr Val Leu Arg Met Ala Val Gln His Met Lys Thr Leu Arg Gly Ala 
        115                 120                 125             


Thr Asn Pro Tyr Thr Glu Ala Asn Tyr Lys Pro Thr Phe Leu Ser Asp 
    130                 135                 140                 


Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe 
145                 150                 155                 160 


Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val 
                165                 170                 175     


Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu 
            180                 185                 190         


Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu 
        195                 200                 205             


Ser Ser Ser Asp Thr Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Thr 
    210                 215                 220                 


Gly Leu Pro Val Lys Thr Asp Ile Thr Pro Gly Pro Ser Arg Leu Cys 
225                 230                 235                 240 


Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro 
                245                 250                 255     


Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser Thr Cys Ser Lys Lys 
            260                 265                 270         


Lys Asp Arg Lys Ser Phe Cys Thr Ile His Ser Thr Gly Tyr Leu Lys 
        275                 280                 285             


Ser Trp Pro Pro Thr Lys Met Gly Leu Asp Glu Asp Asn Glu Pro Asp 
    290                 295                 300                 


Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu His 
305                 310                 315                 320 


Ser His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys Ser 
                325                 330                 335     


Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe Val 
            340                 345                 350         


Asp Gln Arg Ala Thr Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu Leu 
        355                 360                 365             


Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His Leu 
    370                 375                 380                 


Ala Glu Cys His Arg Gln Val Leu Gln Thr Arg Glu Lys Ile Thr Thr 
385                 390                 395                 400 


Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Thr Leu Arg 
                405                 410                 415     


Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Thr Lys Glu Val Glu Tyr 
            420                 425                 430         


Ile Val Ser Thr Asn Thr Val Val Leu Ala Asn Val Leu Glu Gly Gly 
        435                 440                 445             


Asp Pro Thr Phe Pro Gln Leu Thr Ala Ser Pro His Ser Met Asp Ser 
    450                 455                 460                 


Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Thr His Pro Thr Val 
465                 470                 475                 480 


Pro Gly Ile Pro Gly Gly Thr Arg Ala Gly Ala Gly Lys Ile Gly Arg 
                485                 490                 495     


Met Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser Ser 
            500                 505                 510         


Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Thr Ser Thr Pro Pro 
        515                 520                 525             


Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly Thr 
    530                 535                 540                 


Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu Asn 
545                 550                 555                 560 


Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn Pro 
                565                 570                 575     


His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser Pro 
            580                 585                 590         


Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu Ala 
        595                 600                 605             


Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp Pro 
    610                 615                 620                 


Leu 
625 


<210>  792
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARPC1A__Homo_sapiens__NP_001177925

<400>  792

Met Pro Gly Thr Gly Ile Val Leu Ile Ala Leu Ser Pro Asn Asn His 
1               5                   10                  15      


Glu Val His Ile Tyr Lys Lys Asn Gly Ser Gln Trp Val Lys Ala His 
            20                  25                  30          


Glu Leu Lys Glu His Asn Gly His Ile Thr Gly Ile Asp Trp Ala Pro 
        35                  40                  45              


Lys Ser Asp Arg Ile Val Thr Cys Gly Ala Asp Arg Asn Ala Tyr Val 
    50                  55                  60                  


Trp Ser Gln Lys Asp Gly Val Trp Lys Pro Thr Leu Val Ile Leu Arg 
65                  70                  75                  80  


Ile Asn Arg Ala Ala Thr Phe Val Lys Trp Ser Pro Leu Glu Asn Lys 
                85                  90                  95      


Phe Ala Val Gly Ser Gly Ala Arg Leu Ile Ser Val Cys Tyr Phe Glu 
            100                 105                 110         


Ser Glu Asn Asp Trp Trp Val Ser Lys His Ile Lys Lys Pro Ile Arg 
        115                 120                 125             


Ser Thr Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala 
    130                 135                 140                 


Ala Gly Ser Cys Asp Phe Lys Cys Arg Val Phe Ser Ala Tyr Ile Lys 
145                 150                 155                 160 


Glu Val Asp Glu Lys Pro Ala Ser Thr Pro Trp Gly Ser Lys Met Pro 
                165                 170                 175     


Phe Gly Gln Leu Met Ser Glu Phe Gly Gly Ser Gly Thr Gly Gly Trp 
            180                 185                 190         


Val His Gly Val Ser Phe Ser Ala Ser Gly Ser Arg Leu Ala Trp Val 
        195                 200                 205             


Ser His Asp Ser Thr Val Ser Val Ala Asp Ala Ser Lys Ser Val Gln 
    210                 215                 220                 


Val Ser Thr Leu Lys Thr Glu Phe Leu Pro Leu Leu Ser Val Ser Phe 
225                 230                 235                 240 


Val Ser Glu Asn Ser Val Val Ala Ala Gly His Asp Cys Cys Pro Met 
                245                 250                 255     


Leu Phe Asn Tyr Asp Asp Arg Gly Cys Leu Thr Phe Val Ser Lys Leu 
            260                 265                 270         


Asp Ile Pro Lys Gln Ser Ile Gln Arg Asn Met Ser Ala Met Glu Arg 
        275                 280                 285             


Phe Arg Asn Met Asp Lys Arg Ala Thr Thr Glu Asp Arg Asn Thr Ala 
    290                 295                 300                 


Leu Glu Thr Leu His Gln Asn Ser Ile Thr Gln Val Ser Ile Tyr Glu 
305                 310                 315                 320 


Val Asp Lys Gln Asp Cys Arg Lys Phe Cys Thr Thr Gly Ile Asp Gly 
                325                 330                 335     


Ala Met Thr Ile Trp Asp Phe Lys Thr Leu Glu Ser Ser Ile Gln Gly 
            340                 345                 350         


Leu Arg Ile Met 
        355     


<210>  793
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARPC1B__Homo_sapiens__NP_005711

<400>  793

Met Ala Tyr His Ser Phe Leu Val Glu Pro Ile Ser Cys His Ala Trp 
1               5                   10                  15      


Asn Lys Asp Arg Thr Gln Ile Ala Ile Cys Pro Asn Asn His Glu Val 
            20                  25                  30          


His Ile Tyr Glu Lys Ser Gly Ala Lys Trp Thr Lys Val His Glu Leu 
        35                  40                  45              


Lys Glu His Asn Gly Gln Val Thr Gly Ile Asp Trp Ala Pro Glu Ser 
    50                  55                  60                  


Asn Arg Ile Val Thr Cys Gly Thr Asp Arg Asn Ala Tyr Val Trp Thr 
65                  70                  75                  80  


Leu Lys Gly Arg Thr Trp Lys Pro Thr Leu Val Ile Leu Arg Ile Asn 
                85                  90                  95      


Arg Ala Ala Arg Cys Val Arg Trp Ala Pro Asn Glu Asn Lys Phe Ala 
            100                 105                 110         


Val Gly Ser Gly Ser Arg Val Ile Ser Ile Cys Tyr Phe Glu Gln Glu 
        115                 120                 125             


Asn Asp Trp Trp Val Cys Lys His Ile Lys Lys Pro Ile Arg Ser Thr 
    130                 135                 140                 


Val Leu Ser Leu Asp Trp His Pro Asn Asn Val Leu Leu Ala Ala Gly 
145                 150                 155                 160 


Ser Cys Asp Phe Lys Cys Arg Ile Phe Ser Ala Tyr Ile Lys Glu Val 
                165                 170                 175     


Glu Glu Arg Pro Ala Pro Thr Pro Trp Gly Ser Lys Met Pro Phe Gly 
            180                 185                 190         


Glu Leu Met Phe Glu Ser Ser Ser Ser Cys Gly Trp Val His Gly Val 
        195                 200                 205             


Cys Phe Ser Ala Ser Gly Ser Arg Val Ala Trp Val Ser His Asp Ser 
    210                 215                 220                 


Thr Val Cys Leu Ala Asp Ala Asp Lys Lys Met Ala Val Ala Thr Leu 
225                 230                 235                 240 


Ala Ser Glu Thr Leu Pro Leu Leu Ala Leu Thr Phe Ile Thr Asp Asn 
                245                 250                 255     


Ser Leu Val Ala Ala Gly His Asp Cys Phe Pro Val Leu Phe Thr Tyr 
            260                 265                 270         


Asp Ala Ala Ala Gly Met Leu Ser Phe Gly Gly Arg Leu Asp Val Pro 
        275                 280                 285             


Lys Gln Ser Ser Gln Arg Gly Leu Thr Ala Arg Glu Arg Phe Gln Asn 
    290                 295                 300                 


Leu Asp Lys Lys Ala Ser Ser Glu Gly Gly Thr Ala Ala Gly Ala Gly 
305                 310                 315                 320 


Leu Asp Ser Leu His Lys Asn Ser Val Ser Gln Ile Ser Val Leu Ser 
                325                 330                 335     


Gly Gly Lys Ala Lys Cys Ser Gln Phe Cys Thr Thr Gly Met Asp Gly 
            340                 345                 350         


Gly Met Ser Ile Trp Asp Val Lys Ser Leu Glu Ser Ala Leu Lys Asp 
        355                 360                 365             


Leu Lys Ile Lys 
    370         


<210>  794
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARPC2__Homo_sapiens__NP_005722

<400>  794

Met Ile Leu Leu Glu Val Asn Asn Arg Ile Ile Glu Glu Thr Leu Ala 
1               5                   10                  15      


Leu Lys Phe Glu Asn Ala Ala Ala Gly Asn Lys Pro Glu Ala Val Glu 
            20                  25                  30          


Val Thr Phe Ala Asp Phe Asp Gly Val Leu Tyr His Ile Ser Asn Pro 
        35                  40                  45              


Asn Gly Asp Lys Thr Lys Val Met Val Ser Ile Ser Leu Lys Phe Tyr 
    50                  55                  60                  


Lys Glu Leu Gln Ala His Gly Ala Asp Glu Leu Leu Lys Arg Val Tyr 
65                  70                  75                  80  


Gly Ser Phe Leu Val Asn Pro Glu Ser Gly Tyr Asn Val Ser Leu Leu 
                85                  90                  95      


Tyr Asp Leu Glu Asn Leu Pro Ala Ser Lys Asp Ser Ile Val His Gln 
            100                 105                 110         


Ala Gly Met Leu Lys Arg Asn Cys Phe Ala Ser Val Phe Glu Lys Tyr 
        115                 120                 125             


Phe Gln Phe Gln Glu Glu Gly Lys Glu Gly Glu Asn Arg Ala Val Ile 
    130                 135                 140                 


His Tyr Arg Asp Asp Glu Thr Met Tyr Val Glu Ser Lys Lys Asp Arg 
145                 150                 155                 160 


Val Thr Val Val Phe Ser Thr Val Phe Lys Asp Asp Asp Asp Val Val 
                165                 170                 175     


Ile Gly Lys Val Phe Met Gln Glu Phe Lys Glu Gly Arg Arg Ala Ser 
            180                 185                 190         


His Thr Ala Pro Gln Val Leu Phe Ser His Arg Glu Pro Pro Leu Glu 
        195                 200                 205             


Leu Lys Asp Thr Asp Ala Ala Val Gly Asp Asn Ile Gly Tyr Ile Thr 
    210                 215                 220                 


Phe Val Leu Phe Pro Arg His Thr Asn Ala Ser Ala Arg Asp Asn Thr 
225                 230                 235                 240 


Ile Asn Leu Ile His Thr Phe Arg Asp Tyr Leu His Tyr His Ile Lys 
                245                 250                 255     


Cys Ser Lys Ala Tyr Ile His Thr Arg Met Arg Ala Lys Thr Ser Asp 
            260                 265                 270         


Phe Leu Lys Val Leu Asn Arg Ala Arg Pro Asp Ala Glu Lys Lys Glu 
        275                 280                 285             


Met Lys Thr Ile Thr Gly Lys Thr Phe Ser Ser Arg 
    290                 295                 300 


<210>  795
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARPC3__Homo_sapiens__NP_001265485

<400>  795

Met Pro Ala Tyr His Ser Ser Leu Met Asp Pro Asp Thr Lys Leu Ile 
1               5                   10                  15      


Gly Asn Met Ala Leu Leu Pro Ile Arg Ser Gln Phe Lys Gly Pro Ala 
            20                  25                  30          


Pro Arg Glu Thr Lys Asp Thr Asp Ile Val Asp Glu Ala Ile Tyr Tyr 
        35                  40                  45              


Phe Lys Ala Asn Val Phe Phe Lys Asn Tyr Glu Ile Lys Asn Glu Ala 
    50                  55                  60                  


Asp Arg Thr Leu Ile Tyr Ile Thr Leu Tyr Ile Ser Glu Cys Leu Lys 
65                  70                  75                  80  


Lys Leu Gln Lys Cys Asn Ser Lys Ser Gln Gly Glu Lys Glu Met Tyr 
                85                  90                  95      


Thr Leu Gly Ile Thr Asn Phe Pro Ile Pro Gly Glu Pro Gly Phe Pro 
            100                 105                 110         


Leu Asn Ala Ile Tyr Ala Lys Pro Ala Asn Lys Gln Glu Asp Glu Val 
        115                 120                 125             


Met Arg Ala Tyr Leu Gln Gln Leu Arg Gln Glu Thr Gly Leu Arg Leu 
    130                 135                 140                 


Cys Glu Lys Val Phe Asp Pro Gln Asn Asp Lys Pro Ser Lys Trp Trp 
145                 150                 155                 160 


Thr Cys Phe Val Lys Arg Gln Phe Met Asn Lys Ser Leu Ser Gly Pro 
                165                 170                 175     


Gly Gln 
        


<210>  796
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARPC5__Homo_sapiens__NP_001257368

<400>  796

Met Ser Lys Asn Thr Val Ser Ser Ala Arg Phe Arg Lys Val Asp Val 
1               5                   10                  15      


Asp Glu Tyr Asp Glu Asn Lys Phe Val Asp Glu Glu Asp Gly Gly Asp 
            20                  25                  30          


Gly Gln Ala Gly Pro Asp Glu Gly Glu Val Asp Ser Cys Leu Arg His 
        35                  40                  45              


Ser Ile Thr Gly Asn Met Thr Ala Ala Leu Gln Ala Ala Leu Lys Asn 
    50                  55                  60                  


Pro Pro Ile Asn Thr Lys Ser Gln Ala Val Lys Asp Arg Ala Gly Ser 
65                  70                  75                  80  


Ile Val Leu Lys Val Leu Ile Ser Phe Lys Ala Asn Asp Ile Glu Lys 
                85                  90                  95      


Ala Val Gln Ser Leu Asp Lys Asn Gly Val Asp Leu Leu Met Lys Tyr 
            100                 105                 110         


Ile Tyr Lys Gly Phe Glu Ser Pro Ser Asp Asn Ser Ser Ala Met Leu 
        115                 120                 125             


Leu Gln Trp His Glu Lys Ala Leu Ala Ala Gly Gly Val Gly Ser Ile 
    130                 135                 140                 


Val Arg Val Leu Thr Ala Arg Lys Thr Val 
145                 150                 


<210>  797
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARPIN__Homo_sapiens__NP_872422

<400>  797

Met Ser Arg Ile Tyr His Asp Gly Ala Leu Arg Asn Lys Ala Val Gln 
1               5                   10                  15      


Ser Val Arg Leu Pro Gly Ala Trp Asp Pro Ala Ala His Gln Gly Gly 
            20                  25                  30          


Asn Gly Val Leu Leu Glu Gly Glu Leu Ile Asp Val Ser Arg His Ser 
        35                  40                  45              


Ile Leu Asp Thr His Gly Arg Lys Glu Arg Tyr Tyr Val Leu Tyr Ile 
    50                  55                  60                  


Arg Pro Ser His Ile His Arg Arg Lys Phe Asp Ala Lys Gly Asn Glu 
65                  70                  75                  80  


Ile Glu Pro Asn Phe Ser Ala Thr Arg Lys Val Asn Thr Gly Phe Leu 
                85                  90                  95      


Met Ser Ser Tyr Lys Val Glu Ala Lys Gly Asp Thr Asp Arg Leu Thr 
            100                 105                 110         


Pro Glu Ala Leu Lys Gly Leu Val Asn Lys Pro Glu Leu Leu Ala Leu 
        115                 120                 125             


Thr Glu Ser Leu Thr Pro Asp His Thr Val Ala Phe Trp Met Pro Glu 
    130                 135                 140                 


Ser Glu Met Glu Val Met Glu Leu Glu Leu Gly Ala Gly Val Arg Leu 
145                 150                 155                 160 


Lys Thr Arg Gly Asp Gly Pro Phe Leu Asp Ser Leu Ala Lys Leu Glu 
                165                 170                 175     


Ala Gly Thr Val Thr Lys Cys Asn Phe Thr Gly Asp Gly Lys Thr Gly 
            180                 185                 190         


Ala Ser Trp Thr Asp Asn Ile Met Ala Gln Lys Cys Ser Lys Gly Ala 
        195                 200                 205             


Ala Ala Glu Ile Arg Glu Gln Gly Asp Gly Ala Glu Asp Glu Glu Trp 
    210                 215                 220                 


Asp Asp 
225     


<210>  798
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARPP21__Homo_sapiens__NP_001020240

<400>  798

Met Ser Glu Gln Gly Asp Leu Asn Gln Ala Ile Ala Glu Glu Gly Gly 
1               5                   10                  15      


Thr Glu Gln Glu Thr Ala Thr Pro Glu Asn Gly Ile Val Lys Ser Glu 
            20                  25                  30          


Ser Leu Asp Glu Glu Glu Lys Leu Glu Leu Gln Arg Arg Leu Glu Ala 
        35                  40                  45              


Gln Asn Gln Glu Arg Arg Lys Ser Lys Ser Gly Ala Gly Lys Gly Lys 
    50                  55                  60                  


Leu Thr Arg Ser Leu Ala Val Cys Glu Glu Ser Ser Ala Arg Pro Gly 
65                  70                  75                  80  


Gly Glu Ser Leu Gln Asp Gln Thr Leu 
                85                  


<210>  799
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARR3__Homo_sapiens__NP_004303

<400>  799

Met Ser Lys Val Phe Lys Lys Thr Ser Ser Asn Gly Lys Leu Ser Ile 
1               5                   10                  15      


Tyr Leu Gly Lys Arg Asp Phe Val Asp His Val Asp Thr Val Glu Pro 
            20                  25                  30          


Ile Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu Lys Cys Arg Lys 
        35                  40                  45              


Leu Phe Val Met Leu Thr Cys Ala Phe Arg Tyr Gly Arg Asp Asp Leu 
    50                  55                  60                  


Glu Val Ile Gly Leu Thr Phe Arg Lys Asp Leu Tyr Val Gln Thr Leu 
65                  70                  75                  80  


Gln Val Val Pro Ala Glu Ser Ser Ser Pro Gln Gly Pro Leu Thr Val 
                85                  90                  95      


Leu Gln Glu Arg Leu Leu His Lys Leu Gly Asp Asn Ala Tyr Pro Phe 
            100                 105                 110         


Thr Leu Gln Met Val Thr Asn Leu Pro Cys Ser Val Thr Leu Gln Pro 
        115                 120                 125             


Gly Pro Glu Asp Ala Gly Lys Pro Cys Gly Ile Asp Phe Glu Val Lys 
    130                 135                 140                 


Ser Phe Cys Ala Glu Asn Pro Glu Glu Thr Val Ser Lys Arg Asp Tyr 
145                 150                 155                 160 


Val Arg Leu Val Val Arg Lys Val Gln Phe Ala Pro Pro Glu Ala Gly 
                165                 170                 175     


Pro Gly Pro Ser Ala Gln Thr Ile Arg Arg Phe Leu Leu Ser Ala Gln 
            180                 185                 190         


Pro Leu Gln Leu Gln Ala Trp Met Asp Arg Glu Val His Tyr His Gly 
        195                 200                 205             


Glu Pro Ile Ser Val Asn Val Ser Ile Asn Asn Cys Thr Asn Lys Val 
    210                 215                 220                 


Ile Lys Lys Ile Lys Ile Ser Val Asp Gln Ile Thr Asp Val Val Leu 
225                 230                 235                 240 


Tyr Ser Leu Asp Lys Tyr Thr Lys Thr Val Phe Ile Gln Glu Phe Thr 
                245                 250                 255     


Glu Thr Val Ala Ala Asn Ser Ser Phe Ser Gln Ser Phe Ala Val Thr 
            260                 265                 270         


Pro Ile Leu Ala Ala Ser Cys Gln Lys Arg Gly Leu Ala Leu Asp Gly 
        275                 280                 285             


Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Arg 
    290                 295                 300                 


Pro Gly Met Asp Lys Glu Leu Leu Gly Ile Leu Val Ser Tyr Lys Val 
305                 310                 315                 320 


Arg Val Asn Leu Met Val Ser Cys Gly Gly Ile Leu Gly Asp Leu Thr 
                325                 330                 335     


Ala Ser Asp Val Gly Val Glu Leu Pro Leu Val Leu Ile His Pro Lys 
            340                 345                 350         


Pro Ser His Glu Ala Ala Ser Ser Glu Asp Ile Val Ile Glu Glu Phe 
        355                 360                 365             


Thr Arg Lys Gly Glu Glu Glu Ser Gln Lys Ala Val Glu Ala Glu Gly 
    370                 375                 380                 


Asp Glu Gly Ser 
385             


<210>  800
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARRB1__Homo_sapiens__NP_004032

<400>  800

Met Gly Asp Lys Gly Thr Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Thr Leu Thr Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Thr Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Thr Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Thr Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Thr 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gly Pro Gln Pro Thr Ala Glu Thr Thr Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Thr Asn Asn Thr 
    210                 215                 220                 


Asn Lys Thr Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Thr Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Thr Val Ala Pro Ser Ser Thr Phe Cys Lys Val Tyr 
            260                 265                 270         


Thr Leu Thr Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Leu Leu Gly 
                325                 330                 335     


Asp Leu Ala Ser Ser Asp Val Ala Val Glu Leu Pro Phe Thr Leu Met 
            340                 345                 350         


His Pro Lys Pro Lys Glu Glu Pro Pro His Arg Glu Val Pro Glu Asn 
        355                 360                 365             


Glu Thr Pro Val Asp Thr Asn Leu Ile Glu Leu Asp Thr Asn Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Gln Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Lys Glu Glu Glu Glu Asp Gly Thr Gly Ser Pro Gln Leu Asn 
                405                 410                 415     


Asn Arg 
        


<210>  801
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARRB2__Homo_sapiens__NP_001244258

<400>  801

Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              


Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
    50                  55                  60                  


Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  


Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                85                  90                  95      


Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
            100                 105                 110         


Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             


Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 


Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser His 
145                 150                 155                 160 


Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     


Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
            180                 185                 190         


Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
        195                 200                 205             


Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn Asn 
    210                 215                 220                 


Ser Thr Lys Thr Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
225                 230                 235                 240 


Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala Gln 
                245                 250                 255     


Leu Glu Gln Asp Asp Gln Arg Glu Gly Gly Cys Gln Gln Gly Gly Ala 
            260                 265                 270         


Gly Asn Pro Gly Val Leu Gln Gly Gln Gly Glu Ala Gly Gly Val Ser 
        275                 280                 285             


Arg Arg Gly Cys Leu Cys Gly Ala Ala Phe Cys Ser Tyr Ala Pro Gln 
    290                 295                 300                 


Ala Pro Arg Pro His Pro Pro Pro Gln Thr Pro Val Ser Arg Ser Gly 
305                 310                 315                 320 


Asp Arg Cys Pro Cys Gly His Gln Pro His 
                325                 330 


<210>  802
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARRDC2__Homo_sapiens__NP_001020775

<400>  802

Met Arg Ser Gly Gly Val Arg Ser Phe Ala Leu Glu Leu Ala Arg Gly 
1               5                   10                  15      


Pro Gly Gly Ala Tyr Arg Gly Gly Glu Arg Leu Cys Gly Arg Val Leu 
            20                  25                  30          


Leu Glu Ala Ala Ala Pro Leu Arg Val Arg Ala Leu Glu Val Lys Ala 
        35                  40                  45              


Arg Gly Gly Ala Ala Thr His Trp Leu Glu Gly Arg Ser Val Gly Val 
    50                  55                  60                  


Asn Ala Val Ser Ser Asp Tyr Ala Ala Ala Glu Thr Tyr Leu Arg Arg 
65                  70                  75                  80  


Arg Gln Leu Leu Leu Arg Asp Thr Gly Glu Thr Thr Thr Leu Pro Pro 
                85                  90                  95      


Gly Arg His Glu Phe Leu Phe Ser Phe Gln Leu Pro Pro Thr Leu Val 
            100                 105                 110         


Thr Ser Phe Glu Gly Lys His Gly Ser Val Arg Tyr Cys Ile Lys Ala 
        115                 120                 125             


Thr Leu His Arg Pro Trp Val Pro Ala Arg Arg Ala Arg Lys Val Phe 
    130                 135                 140                 


Thr Val Ile Glu Pro Val Asp Ile Asn Thr Pro Ala Leu Leu Ala Pro 
145                 150                 155                 160 


Gln Ala Gly Ala Arg Glu Lys Val Ala Arg Ser Trp Tyr Cys Asn Arg 
                165                 170                 175     


Gly Leu Val Ser Leu Ser Ala Lys Ile Asp Arg Lys Gly Tyr Thr Pro 
            180                 185                 190         


Gly Glu Val Ile Pro Val Phe Ala Glu Ile Asp Asn Gly Ser Thr Arg 
        195                 200                 205             


Pro Val Leu Pro Arg Ala Ala Val Val Gln Thr Gln Thr Phe Met Ala 
    210                 215                 220                 


Arg Gly Ala Arg Lys Gln Lys Arg Ala Val Val Ala Ser Leu Ala Gly 
225                 230                 235                 240 


Glu Pro Val Gly Pro Gly Gln Arg Ala Leu Trp Gln Gly Arg Ala Leu 
                245                 250                 255     


Arg Ile Pro Pro Val Gly Pro Ser Ile Leu His Cys Arg Val Leu His 
            260                 265                 270         


Val Asp Tyr Ala Leu Lys Val Cys Val Asp Ile Pro Gly Thr Ser Lys 
        275                 280                 285             


Leu Leu Leu Glu Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro 
    290                 295                 300                 


Phe Gly Ser Arg Ser Ser Ser Val Gly Ser His Ala Ser Phe Leu Leu 
305                 310                 315                 320 


Asp Trp Arg Leu Gly Ala Leu Pro Glu Arg Pro Glu Ala Pro Pro Glu 
                325                 330                 335     


Tyr Ser Glu Val Val Ala Asp Thr Glu Glu Ala Ala Leu Gly Gln Ser 
            340                 345                 350         


Pro Phe Pro Leu Pro Gln Asp Pro Asp Met Ser Leu Glu Gly Pro Phe 
        355                 360                 365             


Phe Ala Tyr Ile Gln Glu Phe Arg Tyr Arg Pro Pro Pro Leu Tyr Ser 
    370                 375                 380                 


Glu Glu Asp Pro Asn Pro Leu Leu Gly Asp Met Arg Pro Arg Cys Met 
385                 390                 395                 400 


Thr Cys 
        


<210>  803
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARRDC3__Homo_sapiens__NP_065852

<400>  803

Met Val Leu Gly Lys Val Lys Ser Leu Thr Ile Ser Phe Asp Cys Leu 
1               5                   10                  15      


Asn Asp Ser Asn Val Pro Val Tyr Ser Ser Gly Asp Thr Val Ser Gly 
            20                  25                  30          


Arg Val Asn Leu Glu Val Thr Gly Glu Ile Arg Val Lys Ser Leu Lys 
        35                  40                  45              


Ile His Ala Arg Gly His Ala Lys Val Arg Trp Thr Glu Ser Arg Asn 
    50                  55                  60                  


Ala Gly Ser Asn Thr Ala Tyr Thr Gln Asn Tyr Thr Glu Glu Val Glu 
65                  70                  75                  80  


Tyr Phe Asn His Lys Asp Ile Leu Ile Gly His Glu Arg Asp Asp Asp 
                85                  90                  95      


Asn Ser Glu Glu Gly Phe His Thr Ile His Ser Gly Arg His Glu Tyr 
            100                 105                 110         


Ala Phe Ser Phe Glu Leu Pro Gln Thr Pro Leu Ala Thr Ser Phe Glu 
        115                 120                 125             


Gly Arg His Gly Ser Val Arg Tyr Trp Val Lys Ala Glu Leu His Arg 
    130                 135                 140                 


Pro Trp Leu Leu Pro Val Lys Leu Lys Lys Glu Phe Thr Val Phe Glu 
145                 150                 155                 160 


His Ile Asp Ile Asn Thr Pro Ser Leu Leu Ser Pro Gln Ala Gly Thr 
                165                 170                 175     


Lys Glu Lys Thr Leu Cys Cys Trp Phe Cys Thr Ser Gly Pro Ile Ser 
            180                 185                 190         


Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Thr Pro Gly Glu Ser Ile 
        195                 200                 205             


Gln Ile Phe Ala Glu Ile Glu Asn Cys Ser Ser Arg Met Val Val Pro 
    210                 215                 220                 


Lys Ala Ala Ile Tyr Gln Thr Gln Ala Phe Tyr Ala Lys Gly Lys Met 
225                 230                 235                 240 


Lys Glu Val Lys Gln Leu Val Ala Asn Leu Arg Gly Glu Ser Leu Ser 
                245                 250                 255     


Ser Gly Lys Thr Glu Thr Trp Asn Gly Lys Leu Leu Lys Ile Pro Pro 
            260                 265                 270         


Val Ser Pro Ser Ile Leu Asp Cys Ser Ile Ile Arg Val Glu Tyr Ser 
        275                 280                 285             


Leu Met Val Tyr Val Asp Ile Pro Gly Ala Met Asp Leu Phe Leu Asn 
    290                 295                 300                 


Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro Phe Gly Ser Arg 
305                 310                 315                 320 


Thr Ser Ser Val Ser Ser Gln Cys Ser Met Asn Met Asn Trp Leu Ser 
                325                 330                 335     


Leu Ser Leu Pro Glu Arg Pro Glu Ala Pro Pro Ser Tyr Ala Glu Val 
            340                 345                 350         


Val Thr Glu Glu Gln Arg Arg Asn Asn Leu Ala Pro Val Ser Ala Cys 
        355                 360                 365             


Asp Asp Phe Glu Arg Ala Leu Gln Gly Pro Leu Phe Ala Tyr Ile Gln 
    370                 375                 380                 


Glu Phe Arg Phe Leu Pro Pro Pro Leu Tyr Ser Glu Ile Asp Pro Asn 
385                 390                 395                 400 


Pro Asp Gln Ser Ala Asp Asp Arg Pro Ser Cys Pro Ser Arg 
                405                 410                 


<210>  804
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARRDC4__Homo_sapiens__NP_899232

<400>  804

Met Gly Gly Glu Ala Gly Cys Ala Ala Ala Val Gly Ala Glu Gly Arg 
1               5                   10                  15      


Val Lys Ser Leu Gly Leu Val Phe Glu Asp Glu Arg Lys Gly Cys Tyr 
            20                  25                  30          


Ser Ser Gly Glu Thr Val Ala Gly His Val Leu Leu Glu Ala Ser Glu 
        35                  40                  45              


Pro Val Ala Leu Arg Ala Leu Arg Leu Glu Ala Gln Gly Arg Ala Thr 
    50                  55                  60                  


Ala Ala Trp Gly Pro Ser Thr Cys Pro Arg Ala Ser Ala Ser Thr Ala 
65                  70                  75                  80  


Ala Leu Ala Val Phe Ser Glu Val Glu Tyr Leu Asn Val Arg Leu Ser 
                85                  90                  95      


Leu Arg Glu Pro Pro Ala Gly Glu Gly Ile Ile Leu Leu Gln Pro Gly 
            100                 105                 110         


Lys His Glu Phe Pro Phe Arg Phe Gln Leu Pro Ser Glu Pro Leu Val 
        115                 120                 125             


Thr Ser Phe Thr Gly Lys Tyr Gly Ser Ile Gln Tyr Cys Val Arg Ala 
    130                 135                 140                 


Val Leu Glu Arg Pro Lys Val Pro Asp Gln Ser Val Lys Arg Glu Leu 
145                 150                 155                 160 


Gln Val Val Ser His Val Asp Val Asn Thr Pro Ala Leu Leu Thr Pro 
                165                 170                 175     


Val Leu Lys Thr Gln Glu Lys Met Val Gly Cys Trp Phe Phe Thr Ser 
            180                 185                 190         


Gly Pro Val Ser Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Cys Asn 
        195                 200                 205             


Gly Glu Ala Ile Pro Ile Tyr Ala Glu Ile Glu Asn Cys Ser Ser Arg 
    210                 215                 220                 


Leu Ile Val Pro Lys Ala Ala Ile Phe Gln Thr Gln Thr Tyr Leu Ala 
225                 230                 235                 240 


Ser Gly Lys Thr Lys Thr Ile Arg His Met Val Ala Asn Val Arg Gly 
                245                 250                 255     


Asn His Ile Ala Ser Gly Ser Thr Asp Thr Trp Asn Gly Lys Thr Leu 
            260                 265                 270         


Lys Ile Pro Pro Val Thr Pro Ser Ile Leu Asp Cys Cys Ile Ile Arg 
        275                 280                 285             


Val Asp Tyr Ser Leu Ala Val Tyr Ile His Ile Pro Gly Ala Lys Lys 
    290                 295                 300                 


Leu Met Leu Glu Leu Pro Leu Val Ile Gly Thr Ile Pro Tyr Asn Gly 
305                 310                 315                 320 


Phe Gly Ser Arg Asn Ser Ser Ile Ala Ser Gln Phe Ser Met Asp Met 
                325                 330                 335     


Ser Trp Leu Thr Leu Thr Leu Pro Glu Gln Pro Glu Ala Pro Pro Asn 
            340                 345                 350         


Tyr Ala Asp Val Val Ser Glu Glu Glu Phe Ser Arg His Ile Pro Pro 
        355                 360                 365             


Tyr Pro Gln Pro Pro Asn Cys Glu Gly Glu Val Cys Cys Pro Val Phe 
    370                 375                 380                 


Ala Cys Ile Gln Glu Phe Arg Phe Gln Pro Pro Pro Leu Tyr Ser Glu 
385                 390                 395                 400 


Val Asp Pro His Pro Ser Asp Val Glu Glu Ser Gln Pro Val Ser Phe 
                405                 410                 415     


Ile Leu 
        


<210>  805
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSA__Homo_sapiens__NP_001078895

<400>  805

Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  806
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSB__Homo_sapiens__NP_000037

<400>  806

Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             


<210>  807
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSD__Homo_sapiens__NP_001660

<400>  807

Met Arg Ser Ala Ala Arg Arg Gly Arg Ala Ala Pro Ala Ala Arg Asp 
1               5                   10                  15      


Ser Leu Pro Val Leu Leu Phe Leu Cys Leu Leu Leu Lys Thr Cys Glu 
            20                  25                  30          


Pro Lys Thr Ala Asn Ala Phe Lys Pro Asn Ile Leu Leu Ile Met Ala 
        35                  40                  45              


Asp Asp Leu Gly Thr Gly Asp Leu Gly Cys Tyr Gly Asn Asn Thr Leu 
    50                  55                  60                  


Arg Thr Pro Asn Ile Asp Gln Leu Ala Glu Glu Gly Val Arg Leu Thr 
65                  70                  75                  80  


Gln His Leu Ala Ala Ala Pro Leu Cys Thr Pro Ser Arg Ala Ala Phe 
                85                  90                  95      


Leu Thr Gly Arg His Ser Phe Arg Ser Gly Met Asp Ala Ser Asn Gly 
            100                 105                 110         


Tyr Arg Ala Leu Gln Trp Asn Ala Gly Ser Gly Gly Leu Pro Glu Asn 
        115                 120                 125             


Glu Thr Thr Phe Ala Arg Ile Leu Gln Gln His Gly Tyr Ala Thr Gly 
    130                 135                 140                 


Leu Ile Gly Lys Trp His Gln Gly Val Asn Cys Ala Ser Arg Gly Asp 
145                 150                 155                 160 


His Cys His His Pro Leu Asn His Gly Phe Asp Tyr Phe Tyr Gly Met 
                165                 170                 175     


Pro Phe Thr Leu Thr Asn Asp Cys Asp Pro Gly Arg Pro Pro Glu Val 
            180                 185                 190         


Asp Ala Ala Leu Arg Ala Gln Leu Trp Gly Tyr Thr Gln Phe Leu Ala 
        195                 200                 205             


Leu Gly Ile Leu Thr Leu Ala Ala Gly Gln Thr Cys Gly Phe Phe Ser 
    210                 215                 220                 


Val Ser Ala Arg Ala Val Thr Gly Met Ala Gly Val Gly Cys Leu Phe 
225                 230                 235                 240 


Phe Ile Ser Trp Tyr Ser Ser Phe Gly Phe Val Arg Arg Trp Asn Cys 
                245                 250                 255     


Ile Leu Met Arg Asn His Asp Val Thr Glu Gln Pro Met Val Leu Glu 
            260                 265                 270         


Lys Thr Ala Ser Leu Met Leu Lys Glu Ala Val Ser Tyr Ile Glu Arg 
        275                 280                 285             


His Lys His Gly Pro Phe Leu Leu Phe Leu Ser Leu Leu His Val His 
    290                 295                 300                 


Ile Pro Leu Val Thr Thr Ser Ala Phe Leu Gly Lys Ser Gln His Gly 
305                 310                 315                 320 


Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Leu Ile Gly Lys Val 
                325                 330                 335     


Leu Asn Ala Ile Glu Asp Asn Gly Leu Lys Asn Ser Thr Phe Thr Tyr 
            340                 345                 350         


Phe Thr Ser Asp His Gly Gly His Leu Glu Ala Arg Asp Gly His Ser 
        355                 360                 365             


Gln Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly 
    370                 375                 380                 


Gly Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe His Trp Pro Gly 
385                 390                 395                 400 


Val Leu Pro Ala Gly Arg Val Ile Gly Glu Pro Thr Ser Leu Met Asp 
                405                 410                 415     


Val Phe Pro Thr Val Val Gln Leu Val Gly Gly Glu Val Pro Gln Asp 
            420                 425                 430         


Arg Val Ile Asp Gly His Ser Leu Val Pro Leu Leu Gln Gly Ala Glu 
        435                 440                 445             


Ala Arg Ser Ala His Glu Phe Leu Phe His Tyr Cys Gly Gln His Leu 
    450                 455                 460                 


His Ala Ala Arg Trp His Gln Lys Asp Ser Gly Ser Val Trp Lys Val 
465                 470                 475                 480 


His Tyr Thr Thr Pro Gln Phe His Pro Glu Gly Ala Gly Ala Cys Tyr 
                485                 490                 495     


Gly Arg Gly Val Cys Pro Cys Ser Gly Glu Gly Val Thr His His Arg 
            500                 505                 510         


Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp Pro Ser Glu Ala Arg Pro 
        515                 520                 525             


Leu Thr Pro Asp Ser Glu Pro Leu Tyr His Ala Val Ile Ala Arg Val 
    530                 535                 540                 


Gly Ala Ala Val Ser Glu His Arg Gln Thr Leu Ser Pro Val Pro Gln 
545                 550                 555                 560 


Gln Phe Ser Met Ser Asn Ile Leu Trp Lys Pro Trp Leu Gln Pro Cys 
                565                 570                 575     


Cys Gly His Phe Pro Phe Cys Ser Cys His Glu Asp Gly Asp Gly Thr 
            580                 585                 590         


Pro 
    


<210>  808
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSE__Homo_sapiens__NP_001269557

<400>  808

Met Arg Pro Val Ile Asn Arg Cys Ala Pro Gly Ser Leu Asp Leu Met 
1               5                   10                  15      


Leu Pro Gln Ala Ala Ser Glu Gly Ile Val Phe His Ser Leu Gln Ile 
            20                  25                  30          


Ser Leu Cys Phe Arg Ser Trp Leu Pro Ala Met Leu Ala Val Leu Leu 
        35                  40                  45              


Ser Leu Ala Pro Ser Ala Ser Ser Asp Ile Ser Ala Ser Arg Pro Asn 
    50                  55                  60                  


Ile Leu Leu Leu Met Ala Asp Asp Leu Gly Ile Gly Asp Ile Gly Cys 
65                  70                  75                  80  


Tyr Gly Asn Asn Thr Met Arg Thr Pro Asn Ile Asp Arg Leu Ala Glu 
                85                  90                  95      


Asp Gly Val Lys Leu Thr Gln His Ile Ser Ala Ala Ser Leu Cys Thr 
            100                 105                 110         


Pro Ser Arg Ala Ala Phe Leu Thr Gly Arg Tyr Pro Val Arg Ser Gly 
        115                 120                 125             


Met Val Ser Ser Ile Gly Tyr Arg Val Leu Gln Trp Thr Gly Ala Ser 
    130                 135                 140                 


Gly Gly Leu Pro Thr Asn Glu Thr Thr Phe Ala Lys Ile Leu Lys Glu 
145                 150                 155                 160 


Lys Gly Tyr Ala Thr Gly Leu Ile Gly Lys Trp His Leu Gly Leu Asn 
                165                 170                 175     


Cys Glu Ser Ala Ser Asp His Cys His His Pro Leu His His Gly Phe 
            180                 185                 190         


Asp His Phe Tyr Gly Met Pro Phe Ser Leu Met Gly Asp Cys Ala Arg 
        195                 200                 205             


Trp Glu Leu Ser Glu Lys Arg Val Asn Leu Glu Gln Lys Leu Asn Phe 
    210                 215                 220                 


Leu Phe Gln Val Leu Ala Leu Val Ala Leu Thr Leu Val Ala Gly Lys 
225                 230                 235                 240 


Leu Thr His Leu Ile Pro Val Ser Trp Met Pro Val Ile Trp Ser Ala 
                245                 250                 255     


Leu Ser Ala Val Leu Leu Leu Ala Ser Ser Tyr Phe Val Gly Ala Leu 
            260                 265                 270         


Ile Val His Ala Asp Cys Phe Leu Met Arg Asn His Thr Ile Thr Glu 
        275                 280                 285             


Gln Pro Met Cys Phe Gln Arg Thr Thr Pro Leu Ile Leu Gln Glu Val 
    290                 295                 300                 


Ala Ser Phe Leu Lys Arg Asn Lys His Gly Pro Phe Leu Leu Phe Val 
305                 310                 315                 320 


Ser Phe Leu His Val His Ile Pro Leu Ile Thr Met Glu Asn Phe Leu 
                325                 330                 335     


Gly Lys Ser Leu His Gly Leu Tyr Gly Asp Asn Val Glu Glu Met Asp 
            340                 345                 350         


Trp Met Val Gly Arg Ile Leu Asp Thr Leu Asp Val Glu Gly Leu Ser 
        355                 360                 365             


Asn Ser Thr Leu Ile Tyr Phe Thr Ser Asp His Gly Gly Ser Leu Glu 
    370                 375                 380                 


Asn Gln Leu Gly Asn Thr Gln Tyr Gly Gly Trp Asn Gly Ile Tyr Lys 
385                 390                 395                 400 


Gly Gly Lys Gly Met Gly Gly Trp Glu Gly Gly Ile Arg Val Pro Gly 
                405                 410                 415     


Ile Phe Arg Trp Pro Gly Val Leu Pro Ala Gly Arg Val Ile Gly Glu 
            420                 425                 430         


Pro Thr Ser Leu Met Asp Val Phe Pro Thr Val Val Arg Leu Ala Gly 
        435                 440                 445             


Gly Glu Val Pro Gln Asp Arg Val Ile Asp Gly Gln Asp Leu Leu Pro 
    450                 455                 460                 


Leu Leu Leu Gly Thr Ala Gln His Ser Asp His Glu Phe Leu Met His 
465                 470                 475                 480 


Tyr Cys Glu Arg Phe Leu His Ala Ala Arg Trp His Gln Arg Asp Arg 
                485                 490                 495     


Gly Thr Met Trp Lys Val His Phe Val Thr Pro Val Phe Gln Pro Glu 
            500                 505                 510         


Gly Ala Gly Ala Cys Tyr Gly Arg Lys Val Cys Pro Cys Phe Gly Glu 
        515                 520                 525             


Lys Val Val His His Asp Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp 
    530                 535                 540                 


Pro Ser Glu Thr His Ile Leu Thr Pro Ala Ser Glu Pro Val Phe Tyr 
545                 550                 555                 560 


Gln Val Met Glu Arg Val Gln Gln Ala Val Trp Glu His Gln Arg Thr 
                565                 570                 575     


Leu Ser Pro Val Pro Leu Gln Leu Asp Arg Leu Gly Asn Ile Trp Arg 
            580                 585                 590         


Pro Trp Leu Gln Pro Cys Cys Gly Pro Phe Pro Leu Cys Trp Cys Leu 
        595                 600                 605             


Arg Glu Asp Asp Pro Gln 
    610                 


<210>  809
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSF__Homo_sapiens__NP_004033

<400>  809

Met Arg Pro Arg Arg Pro Leu Val Phe Met Ser Leu Val Cys Ala Leu 
1               5                   10                  15      


Leu Asn Thr Cys Gln Ala His Arg Val His Asp Asp Lys Pro Asn Ile 
            20                  25                  30          


Val Leu Ile Met Val Asp Asp Leu Gly Ile Gly Asp Leu Gly Cys Tyr 
        35                  40                  45              


Gly Asn Asp Thr Met Arg Thr Pro His Ile Asp Arg Leu Ala Arg Glu 
    50                  55                  60                  


Gly Val Arg Leu Thr Gln His Ile Ser Ala Ala Ser Leu Cys Ser Pro 
65                  70                  75                  80  


Ser Arg Ser Ala Phe Leu Thr Gly Arg Tyr Pro Ile Arg Ser Gly Met 
                85                  90                  95      


Val Ser Ser Gly Asn Arg Arg Val Ile Gln Asn Leu Ala Val Pro Ala 
            100                 105                 110         


Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Ala Leu Leu Lys Lys Gln 
        115                 120                 125             


Gly Tyr Ser Thr Gly Leu Ile Gly Lys Trp His Gln Gly Leu Asn Cys 
    130                 135                 140                 


Asp Ser Arg Ser Asp Gln Cys His His Pro Tyr Asn Tyr Gly Phe Asp 
145                 150                 155                 160 


Tyr Tyr Tyr Gly Met Pro Phe Thr Leu Val Asp Ser Cys Trp Pro Asp 
                165                 170                 175     


Pro Ser Arg Asn Thr Glu Leu Ala Phe Glu Ser Gln Leu Trp Leu Cys 
            180                 185                 190         


Val Gln Leu Val Ala Ile Ala Ile Leu Thr Leu Thr Phe Gly Lys Leu 
        195                 200                 205             


Ser Gly Trp Val Ser Val Pro Trp Leu Leu Ile Phe Ser Met Ile Leu 
    210                 215                 220                 


Phe Ile Phe Leu Leu Gly Tyr Ala Trp Phe Ser Ser His Thr Ser Pro 
225                 230                 235                 240 


Leu Tyr Trp Asp Cys Leu Leu Met Arg Gly His Glu Ile Thr Glu Gln 
                245                 250                 255     


Pro Met Lys Ala Glu Arg Ala Gly Ser Ile Met Val Lys Glu Ala Ile 
            260                 265                 270         


Ser Phe Leu Glu Arg His Ser Lys Glu Thr Phe Leu Leu Phe Phe Ser 
        275                 280                 285             


Phe Leu His Val His Thr Pro Leu Pro Thr Thr Asp Asp Phe Thr Gly 
    290                 295                 300                 


Thr Ser Lys His Gly Leu Tyr Gly Asp Asn Val Glu Glu Met Asp Ser 
305                 310                 315                 320 


Met Val Gly Lys Ile Leu Asp Ala Ile Asp Asp Phe Gly Leu Arg Asn 
                325                 330                 335     


Asn Thr Leu Val Tyr Phe Thr Ser Asp His Gly Gly His Leu Glu Ala 
            340                 345                 350         


Arg Arg Gly His Ala Gln Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly 
        355                 360                 365             


Gly Lys Gly Met Gly Gly Trp Glu Gly Gly Ile Arg Val Pro Gly Ile 
    370                 375                 380                 


Val Arg Trp Pro Gly Lys Val Pro Ala Gly Arg Leu Ile Lys Glu Pro 
385                 390                 395                 400 


Thr Ser Leu Met Asp Ile Leu Pro Thr Val Ala Ser Val Ser Gly Gly 
                405                 410                 415     


Ser Leu Pro Gln Asp Arg Val Ile Asp Gly Arg Asp Leu Met Pro Leu 
            420                 425                 430         


Leu Gln Gly Asn Val Arg His Ser Glu His Glu Phe Leu Phe His Tyr 
        435                 440                 445             


Cys Gly Ser Tyr Leu His Ala Val Arg Trp Ile Pro Lys Asp Asp Ser 
    450                 455                 460                 


Gly Ser Val Trp Lys Ala His Tyr Val Thr Pro Val Phe Gln Pro Pro 
465                 470                 475                 480 


Ala Ser Gly Gly Cys Tyr Val Thr Ser Leu Cys Arg Cys Phe Gly Glu 
                485                 490                 495     


Gln Val Thr Tyr His Asn Pro Pro Leu Leu Phe Asp Leu Ser Arg Asp 
            500                 505                 510         


Pro Ser Glu Ser Thr Pro Leu Thr Pro Ala Thr Glu Pro Leu His Asp 
        515                 520                 525             


Phe Val Ile Lys Lys Val Ala Asn Ala Leu Lys Glu His Gln Glu Thr 
    530                 535                 540                 


Ile Val Pro Val Thr Tyr Gln Leu Ser Glu Leu Asn Gln Gly Arg Thr 
545                 550                 555                 560 


Trp Leu Lys Pro Cys Cys Gly Val Phe Pro Phe Cys Leu Cys Asp Lys 
                565                 570                 575     


Glu Glu Glu Val Ser Gln Pro Arg Gly Pro Asn Glu Lys Arg 
            580                 585                 590 


<210>  810
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSG__Homo_sapiens__NP_055775

<400>  810

Met Gly Trp Leu Phe Leu Lys Val Leu Leu Ala Gly Val Ser Phe Ser 
1               5                   10                  15      


Gly Phe Leu Tyr Pro Leu Val Asp Phe Cys Ile Ser Gly Lys Thr Arg 
            20                  25                  30          


Gly Gln Lys Pro Asn Phe Val Ile Ile Leu Ala Asp Asp Met Gly Trp 
        35                  40                  45              


Gly Asp Leu Gly Ala Asn Trp Ala Glu Thr Lys Asp Thr Ala Asn Leu 
    50                  55                  60                  


Asp Lys Met Ala Ser Glu Gly Met Arg Phe Val Asp Phe His Ala Ala 
65                  70                  75                  80  


Ala Ser Thr Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Arg Leu 
                85                  90                  95      


Gly Leu Arg Asn Gly Val Thr Arg Asn Phe Ala Val Thr Ser Val Gly 
            100                 105                 110         


Gly Leu Pro Leu Asn Glu Thr Thr Leu Ala Glu Val Leu Gln Gln Ala 
        115                 120                 125             


Gly Tyr Val Thr Gly Ile Ile Gly Lys Trp His Leu Gly His His Gly 
    130                 135                 140                 


Ser Tyr His Pro Asn Phe Arg Gly Phe Asp Tyr Tyr Phe Gly Ile Pro 
145                 150                 155                 160 


Tyr Ser His Asp Met Gly Cys Thr Asp Thr Pro Gly Tyr Asn His Pro 
                165                 170                 175     


Pro Cys Pro Ala Cys Pro Gln Gly Asp Gly Pro Ser Arg Asn Leu Gln 
            180                 185                 190         


Arg Asp Cys Tyr Thr Asp Val Ala Leu Pro Leu Tyr Glu Asn Leu Asn 
        195                 200                 205             


Ile Val Glu Gln Pro Val Asn Leu Ser Ser Leu Ala Gln Lys Tyr Ala 
    210                 215                 220                 


Glu Lys Ala Thr Gln Phe Ile Gln Arg Ala Ser Thr Ser Gly Arg Pro 
225                 230                 235                 240 


Phe Leu Leu Tyr Val Ala Leu Ala His Met His Val Pro Leu Pro Val 
                245                 250                 255     


Thr Gln Leu Pro Ala Ala Pro Arg Gly Arg Ser Leu Tyr Gly Ala Gly 
            260                 265                 270         


Leu Trp Glu Met Asp Ser Leu Val Gly Gln Ile Lys Asp Lys Val Asp 
        275                 280                 285             


His Thr Val Lys Glu Asn Thr Phe Leu Trp Phe Thr Gly Asp Asn Gly 
    290                 295                 300                 


Pro Trp Ala Gln Lys Cys Glu Leu Ala Gly Ser Val Gly Pro Phe Thr 
305                 310                 315                 320 


Gly Phe Trp Gln Thr Arg Gln Gly Gly Ser Pro Ala Lys Gln Thr Thr 
                325                 330                 335     


Trp Glu Gly Gly His Arg Val Pro Ala Leu Ala Tyr Trp Pro Gly Arg 
            340                 345                 350         


Val Pro Val Asn Val Thr Ser Thr Ala Leu Leu Ser Val Leu Asp Ile 
        355                 360                 365             


Phe Pro Thr Val Val Ala Leu Ala Gln Ala Ser Leu Pro Gln Gly Arg 
    370                 375                 380                 


Arg Phe Asp Gly Val Asp Val Ser Glu Val Leu Phe Gly Arg Ser Gln 
385                 390                 395                 400 


Pro Gly His Arg Val Leu Phe His Pro Asn Ser Gly Ala Ala Gly Glu 
                405                 410                 415     


Phe Gly Ala Leu Gln Thr Val Arg Leu Glu Arg Tyr Lys Ala Phe Tyr 
            420                 425                 430         


Ile Thr Gly Gly Ala Arg Ala Cys Asp Gly Ser Thr Gly Pro Glu Leu 
        435                 440                 445             


Gln His Lys Phe Pro Leu Ile Phe Asn Leu Glu Asp Asp Thr Ala Glu 
    450                 455                 460                 


Ala Val Pro Leu Glu Arg Gly Gly Ala Glu Tyr Gln Ala Val Leu Pro 
465                 470                 475                 480 


Glu Val Arg Lys Val Leu Ala Asp Val Leu Gln Asp Ile Ala Asn Asp 
                485                 490                 495     


Asn Ile Ser Ser Ala Asp Tyr Thr Gln Asp Pro Ser Val Thr Pro Cys 
            500                 505                 510         


Cys Asn Pro Tyr Gln Ile Ala Cys Arg Cys Gln Ala Ala 
        515                 520                 525 


<210>  811
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSH__Homo_sapiens__NP_001011719

<400>  811

Met Thr Arg Asn Ala Arg Pro Asn Ile Val Leu Leu Met Ala Asp Asp 
1               5                   10                  15      


Leu Gly Val Gly Asp Leu Cys Cys Tyr Gly Asn Asn Ser Val Ser Thr 
            20                  25                  30          


Pro Asn Ile Asp Arg Leu Ala Ser Glu Gly Val Arg Leu Thr Gln His 
        35                  40                  45              


Leu Ala Ala Ala Ser Met Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr 
    50                  55                  60                  


Gly Arg Tyr Pro Ile Arg Ser Gly Met Val Ser Ala Tyr Asn Leu Asn 
65                  70                  75                  80  


Arg Ala Phe Thr Trp Leu Gly Gly Ser Gly Gly Leu Pro Thr Asn Glu 
                85                  90                  95      


Thr Thr Phe Ala Lys Leu Leu Gln His Arg Gly Tyr Arg Thr Gly Leu 
            100                 105                 110         


Ile Gly Lys Trp His Leu Gly Leu Ser Cys Ala Ser Arg Asn Asp His 
        115                 120                 125             


Cys Tyr His Pro Leu Asn His Gly Phe His Tyr Phe Tyr Gly Val Pro 
    130                 135                 140                 


Phe Gly Leu Leu Ser Asp Cys Gln Ala Ser Lys Thr Pro Glu Leu His 
145                 150                 155                 160 


Arg Trp Leu Arg Ile Lys Leu Trp Ile Ser Thr Val Ala Leu Ala Leu 
                165                 170                 175     


Val Pro Phe Leu Leu Leu Ile Pro Lys Phe Ala Arg Trp Phe Ser Val 
            180                 185                 190         


Pro Trp Lys Val Ile Phe Val Phe Ala Leu Leu Ala Phe Leu Phe Phe 
        195                 200                 205             


Thr Ser Trp Tyr Ser Ser Tyr Gly Phe Thr Arg Arg Trp Asn Cys Ile 
    210                 215                 220                 


Leu Met Arg Asn His Glu Ile Ile Gln Gln Pro Met Lys Glu Glu Lys 
225                 230                 235                 240 


Val Ala Ser Leu Met Leu Lys Glu Ala Leu Ala Phe Ile Glu Arg Tyr 
                245                 250                 255     


Lys Arg Glu Pro Phe Leu Leu Phe Phe Ser Phe Leu His Val His Thr 
            260                 265                 270         


Pro Leu Ile Ser Lys Lys Lys Phe Val Gly Arg Ser Lys Tyr Gly Arg 
        275                 280                 285             


Tyr Gly Asp Asn Val Glu Glu Met Asp Trp Met Val Gly Lys Ile Leu 
    290                 295                 300                 


Asp Ala Leu Asp Gln Glu Arg Leu Ala Asn His Thr Leu Val Tyr Phe 
305                 310                 315                 320 


Thr Ser Asp Asn Gly Gly His Leu Glu Pro Leu Asp Gly Ala Val Gln 
                325                 330                 335     


Leu Gly Gly Trp Asn Gly Ile Tyr Lys Gly Gly Lys Gly Met Gly Gly 
            340                 345                 350         


Trp Glu Gly Gly Ile Arg Val Pro Gly Ile Phe Arg Trp Pro Ser Val 
        355                 360                 365             


Leu Glu Ala Gly Arg Val Ile Asn Glu Pro Thr Ser Leu Met Asp Ile 
    370                 375                 380                 


Tyr Pro Thr Leu Ser Tyr Ile Gly Gly Gly Ile Leu Ser Gln Asp Arg 
385                 390                 395                 400 


Val Ile Asp Gly Gln Asn Leu Met Pro Leu Leu Glu Gly Arg Ala Ser 
                405                 410                 415     


His Ser Asp His Glu Phe Leu Phe His Tyr Cys Gly Val Tyr Leu His 
            420                 425                 430         


Thr Val Arg Trp His Gln Lys Asp Cys Ala Thr Val Trp Lys Ala His 
        435                 440                 445             


Tyr Val Thr Pro Lys Phe Tyr Pro Glu Gly Thr Gly Ala Cys Tyr Gly 
    450                 455                 460                 


Ser Gly Ile Cys Ser Cys Ser Gly Asp Val Thr Tyr His Asp Pro Pro 
465                 470                 475                 480 


Leu Leu Phe Asp Ile Ser Arg Asp Pro Ser Glu Ala Leu Pro Leu Asn 
                485                 490                 495     


Pro Asp Asn Glu Pro Leu Phe Asp Ser Val Ile Lys Lys Met Glu Ala 
            500                 505                 510         


Ala Ile Arg Glu His Arg Arg Thr Leu Thr Pro Val Pro Gln Gln Phe 
        515                 520                 525             


Ser Val Phe Asn Thr Ile Trp Lys Pro Trp Leu Gln Pro Cys Cys Gly 
    530                 535                 540                 


Thr Phe Pro Phe Cys Gly Cys Asp Lys Glu Asp Asp Ile Leu Pro Met 
545                 550                 555                 560 


Ala Pro 
        


<210>  812
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSI__Homo_sapiens__NP_001012301

<400>  812

Met His Thr Leu Thr Gly Phe Ser Leu Val Ser Leu Leu Ser Phe Gly 
1               5                   10                  15      


Tyr Leu Ser Trp Asp Trp Ala Lys Pro Ser Phe Val Ala Asp Gly Pro 
            20                  25                  30          


Gly Glu Ala Gly Glu Gln Pro Ser Ala Ala Pro Pro Gln Pro Pro His 
        35                  40                  45              


Ile Ile Phe Ile Leu Thr Asp Asp Gln Gly Tyr His Asp Val Gly Tyr 
    50                  55                  60                  


His Gly Ser Asp Ile Glu Thr Pro Thr Leu Asp Arg Leu Ala Ala Lys 
65                  70                  75                  80  


Gly Val Lys Leu Glu Asn Tyr Tyr Ile Gln Pro Ile Cys Thr Pro Ser 
                85                  90                  95      


Arg Ser Gln Leu Leu Thr Gly Arg Tyr Gln Ile His Thr Gly Leu Gln 
            100                 105                 110         


His Ser Ile Ile Arg Pro Gln Gln Pro Asn Cys Leu Pro Leu Asp Gln 
        115                 120                 125             


Val Thr Leu Pro Gln Lys Leu Gln Glu Ala Gly Tyr Ser Thr His Met 
    130                 135                 140                 


Val Gly Lys Trp His Leu Gly Phe Tyr Arg Lys Glu Cys Leu Pro Thr 
145                 150                 155                 160 


Arg Arg Gly Phe Asp Thr Phe Leu Gly Ser Leu Thr Gly Asn Val Asp 
                165                 170                 175     


Tyr Tyr Thr Tyr Asp Asn Cys Asp Gly Pro Gly Val Cys Gly Phe Asp 
            180                 185                 190         


Leu His Glu Gly Glu Asn Val Ala Trp Gly Leu Ser Gly Gln Tyr Ser 
        195                 200                 205             


Thr Met Leu Tyr Ala Gln Arg Ala Ser His Ile Leu Ala Ser His Ser 
    210                 215                 220                 


Pro Gln Arg Pro Leu Phe Leu Tyr Val Ala Phe Gln Ala Val His Thr 
225                 230                 235                 240 


Pro Leu Gln Ser Pro Arg Glu Tyr Leu Tyr Arg Tyr Arg Thr Met Gly 
                245                 250                 255     


Asn Val Ala Arg Arg Lys Tyr Ala Ala Met Val Thr Cys Met Asp Glu 
            260                 265                 270         


Ala Val Arg Asn Ile Thr Trp Ala Leu Lys Arg Tyr Gly Phe Tyr Asn 
        275                 280                 285             


Asn Ser Val Ile Ile Phe Ser Ser Asp Asn Gly Gly Gln Thr Phe Ser 
    290                 295                 300                 


Gly Gly Ser Asn Trp Pro Leu Arg Gly Arg Lys Gly Thr Tyr Trp Glu 
305                 310                 315                 320 


Gly Gly Val Arg Gly Leu Gly Phe Val His Ser Pro Leu Leu Lys Arg 
                325                 330                 335     


Lys Gln Arg Thr Ser Arg Ala Leu Met His Ile Thr Asp Trp Tyr Pro 
            340                 345                 350         


Thr Leu Val Gly Leu Ala Gly Gly Thr Thr Ser Ala Ala Asp Gly Leu 
        355                 360                 365             


Asp Gly Tyr Asp Val Trp Pro Ala Ile Ser Glu Gly Arg Ala Ser Pro 
    370                 375                 380                 


Arg Thr Glu Ile Leu His Asn Ile Asp Pro Leu Tyr Asn His Ala Gln 
385                 390                 395                 400 


His Gly Ser Leu Glu Gly Gly Phe Gly Ile Trp Asn Thr Ala Val Gln 
                405                 410                 415     


Ala Ala Ile Arg Val Gly Glu Trp Lys Leu Leu Thr Gly Asp Pro Gly 
            420                 425                 430         


Tyr Gly Asp Trp Ile Pro Pro Gln Thr Leu Ala Thr Phe Pro Gly Ser 
        435                 440                 445             


Trp Trp Asn Leu Glu Arg Met Ala Ser Val Arg Gln Ala Val Trp Leu 
    450                 455                 460                 


Phe Asn Ile Ser Ala Asp Pro Tyr Glu Arg Glu Asp Leu Ala Gly Gln 
465                 470                 475                 480 


Arg Pro Asp Val Val Arg Thr Leu Leu Ala Arg Leu Ala Glu Tyr Asn 
                485                 490                 495     


Arg Thr Ala Ile Pro Val Arg Tyr Pro Ala Glu Asn Pro Arg Ala His 
            500                 505                 510         


Pro Asp Phe Asn Gly Gly Ala Trp Gly Pro Trp Ala Ser Asp Glu Glu 
        515                 520                 525             


Glu Glu Glu Glu Glu Gly Arg Ala Arg Ser Phe Ser Arg Gly Arg Arg 
    530                 535                 540                 


Lys Lys Lys Cys Lys Ile Cys Lys Leu Arg Ser Phe Phe Arg Lys Leu 
545                 550                 555                 560 


Asn Thr Arg Leu Met Ser Gln Arg Ile 
                565                 


<210>  813
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSJ__Homo_sapiens__NP_078866

<400>  813

Met Ala Pro Arg Gly Cys Ala Gly His Pro Pro Pro Pro Ser Pro Gln 
1               5                   10                  15      


Ala Cys Val Cys Pro Gly Lys Met Leu Ala Met Gly Ala Leu Ala Gly 
            20                  25                  30          


Phe Trp Ile Leu Cys Leu Leu Thr Tyr Gly Tyr Leu Ser Trp Gly Gln 
        35                  40                  45              


Ala Leu Glu Glu Glu Glu Glu Gly Ala Leu Leu Ala Gln Ala Gly Glu 
    50                  55                  60                  


Lys Leu Glu Pro Ser Thr Thr Ser Thr Ser Gln Pro His Leu Ile Phe 
65                  70                  75                  80  


Ile Leu Ala Asp Asp Gln Gly Phe Arg Asp Val Gly Tyr His Gly Ser 
                85                  90                  95      


Glu Ile Lys Thr Pro Thr Leu Asp Lys Leu Ala Ala Glu Gly Val Lys 
            100                 105                 110         


Leu Glu Asn Tyr Tyr Val Gln Pro Ile Cys Thr Pro Ser Arg Ser Gln 
        115                 120                 125             


Phe Ile Thr Gly Lys Tyr Gln Ile His Thr Gly Leu Gln His Ser Ile 
    130                 135                 140                 


Ile Arg Pro Thr Gln Pro Asn Cys Leu Pro Leu Asp Asn Ala Thr Leu 
145                 150                 155                 160 


Pro Gln Lys Leu Lys Glu Val Gly Tyr Ser Thr His Met Val Gly Lys 
                165                 170                 175     


Trp His Leu Gly Phe Tyr Arg Lys Glu Cys Met Pro Thr Arg Arg Gly 
            180                 185                 190         


Phe Asp Thr Phe Phe Gly Ser Leu Leu Gly Ser Gly Asp Tyr Tyr Thr 
        195                 200                 205             


His Tyr Lys Cys Asp Ser Pro Gly Met Cys Gly Tyr Asp Leu Tyr Glu 
    210                 215                 220                 


Asn Asp Asn Ala Ala Trp Asp Tyr Asp Asn Gly Ile Tyr Ser Thr Gln 
225                 230                 235                 240 


Met Tyr Thr Gln Arg Val Gln Gln Ile Leu Ala Ser His Asn Pro Thr 
                245                 250                 255     


Lys Pro Ile Phe Leu Tyr Ile Ala Tyr Gln Ala Val His Ser Pro Leu 
            260                 265                 270         


Gln Ala Pro Gly Arg Tyr Phe Glu His Tyr Arg Ser Ile Ile Asn Ile 
        275                 280                 285             


Asn Arg Arg Arg Tyr Ala Ala Met Leu Ser Cys Leu Asp Glu Ala Ile 
    290                 295                 300                 


Asn Asn Val Thr Leu Ala Leu Lys Thr Tyr Gly Phe Tyr Asn Asn Ser 
305                 310                 315                 320 


Ile Ile Ile Tyr Ser Ser Asp Asn Gly Gly Gln Pro Thr Ala Gly Gly 
                325                 330                 335     


Ser Asn Trp Pro Leu Arg Gly Ser Lys Gly Thr Tyr Trp Glu Gly Gly 
            340                 345                 350         


Ile Arg Ala Val Gly Phe Val His Ser Pro Leu Leu Lys Asn Lys Gly 
        355                 360                 365             


Thr Val Cys Lys Glu Leu Val His Ile Thr Asp Trp Tyr Pro Thr Leu 
    370                 375                 380                 


Ile Ser Leu Ala Glu Gly Gln Ile Asp Glu Asp Ile Gln Leu Asp Gly 
385                 390                 395                 400 


Tyr Asp Ile Trp Glu Thr Ile Ser Glu Gly Leu Arg Ser Pro Arg Val 
                405                 410                 415     


Asp Ile Leu His Asn Ile Asp Pro Ile Tyr Thr Lys Ala Lys Asn Gly 
            420                 425                 430         


Ser Trp Ala Ala Gly Tyr Gly Ile Trp Asn Thr Ala Ile Gln Ser Ala 
        435                 440                 445             


Ile Arg Val Gln His Trp Lys Leu Leu Thr Gly Asn Pro Gly Tyr Ser 
    450                 455                 460                 


Asp Trp Val Pro Pro Gln Ser Phe Ser Asn Leu Gly Pro Asn Arg Trp 
465                 470                 475                 480 


His Asn Glu Arg Ile Thr Leu Ser Thr Gly Lys Ser Val Trp Leu Phe 
                485                 490                 495     


Asn Ile Thr Ala Asp Pro Tyr Glu Arg Val Asp Leu Ser Asn Arg Tyr 
            500                 505                 510         


Pro Gly Ile Val Lys Lys Leu Leu Arg Arg Leu Ser Gln Phe Asn Lys 
        515                 520                 525             


Thr Ala Val Pro Val Arg Tyr Pro Pro Lys Asp Pro Arg Ser Asn Pro 
    530                 535                 540                 


Arg Leu Asn Gly Gly Val Trp Gly Pro Trp Tyr Lys Glu Glu Thr Lys 
545                 550                 555                 560 


Lys Lys Lys Pro Ser Lys Asn Gln Ala Glu Lys Lys Gln Lys Lys Ser 
                565                 570                 575     


Lys Lys Lys Lys Lys Lys Gln Gln Lys Ala Val Ser Gly Ser Thr Cys 
            580                 585                 590         


His Ser Gly Val Thr Cys Gly 
        595                 


<210>  814
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARSK__Homo_sapiens__NP_937793

<400>  814

Met Leu Leu Leu Trp Val Ser Val Val Ala Ala Leu Ala Leu Ala Val 
1               5                   10                  15      


Leu Ala Pro Gly Ala Gly Glu Gln Arg Arg Arg Ala Ala Lys Ala Pro 
            20                  25                  30          


Asn Val Val Leu Val Val Ser Asp Ser Phe Asp Gly Arg Leu Thr Phe 
        35                  40                  45              


His Pro Gly Ser Gln Val Val Lys Leu Pro Phe Ile Asn Phe Met Lys 
    50                  55                  60                  


Thr Arg Gly Thr Ser Phe Leu Asn Ala Tyr Thr Asn Ser Pro Ile Cys 
65                  70                  75                  80  


Cys Pro Ser Arg Ala Ala Met Trp Ser Gly Leu Phe Thr His Leu Thr 
                85                  90                  95      


Glu Ser Trp Asn Asn Phe Lys Gly Leu Asp Pro Asn Tyr Thr Thr Trp 
            100                 105                 110         


Met Asp Val Met Glu Arg His Gly Tyr Arg Thr Gln Lys Phe Gly Lys 
        115                 120                 125             


Leu Asp Tyr Thr Ser Gly His His Ser Ile Ser Asn Arg Val Glu Ala 
    130                 135                 140                 


Trp Thr Arg Asp Val Ala Phe Leu Leu Arg Gln Glu Gly Arg Pro Met 
145                 150                 155                 160 


Val Asn Leu Ile Arg Asn Arg Thr Lys Val Arg Val Met Glu Arg Asp 
                165                 170                 175     


Trp Gln Asn Thr Asp Lys Ala Val Asn Trp Leu Arg Lys Glu Ala Ile 
            180                 185                 190         


Asn Tyr Thr Glu Pro Phe Val Ile Tyr Leu Gly Leu Asn Leu Pro His 
        195                 200                 205             


Pro Tyr Pro Ser Pro Ser Ser Gly Glu Asn Phe Gly Ser Ser Thr Phe 
    210                 215                 220                 


His Thr Ser Leu Tyr Trp Leu Glu Lys Val Ser His Asp Ala Ile Lys 
225                 230                 235                 240 


Ile Pro Lys Trp Ser Pro Leu Ser Glu Met His Pro Val Asp Tyr Tyr 
                245                 250                 255     


Ser Ser Tyr Thr Lys Asn Cys Thr Gly Arg Phe Thr Lys Lys Glu Ile 
            260                 265                 270         


Lys Asn Ile Arg Ala Phe Tyr Tyr Ala Met Cys Ala Glu Thr Asp Ala 
        275                 280                 285             


Met Leu Gly Glu Ile Ile Leu Ala Leu His Gln Leu Asp Leu Leu Gln 
    290                 295                 300                 


Lys Thr Ile Val Ile Tyr Ser Ser Asp His Gly Glu Leu Ala Met Glu 
305                 310                 315                 320 


His Arg Gln Phe Tyr Lys Met Ser Met Tyr Glu Ala Ser Ala His Val 
                325                 330                 335     


Pro Leu Leu Met Met Gly Pro Gly Ile Lys Ala Gly Leu Gln Val Ser 
            340                 345                 350         


Asn Val Val Ser Leu Val Asp Ile Tyr Pro Thr Met Leu Asp Ile Ala 
        355                 360                 365             


Gly Ile Pro Leu Pro Gln Asn Leu Ser Gly Tyr Ser Leu Leu Pro Leu 
    370                 375                 380                 


Ser Ser Glu Thr Phe Lys Asn Glu His Lys Val Lys Asn Leu His Pro 
385                 390                 395                 400 


Pro Trp Ile Leu Ser Glu Phe His Gly Cys Asn Val Asn Ala Ser Thr 
                405                 410                 415     


Tyr Met Leu Arg Thr Asn His Trp Lys Tyr Ile Ala Tyr Ser Asp Gly 
            420                 425                 430         


Ala Ser Ile Leu Pro Gln Leu Phe Asp Leu Ser Ser Asp Pro Asp Glu 
        435                 440                 445             


Leu Thr Asn Val Ala Val Lys Phe Pro Glu Ile Thr Tyr Ser Leu Asp 
    450                 455                 460                 


Gln Lys Leu His Ser Ile Ile Asn Tyr Pro Lys Val Ser Ala Ser Val 
465                 470                 475                 480 


His Gln Tyr Asn Lys Glu Gln Phe Ile Lys Trp Lys Gln Ser Ile Gly 
                485                 490                 495     


Gln Asn Tyr Ser Asn Val Ile Ala Asn Leu Arg Trp His Gln Asp Trp 
            500                 505                 510         


Gln Lys Glu Pro Arg Lys Tyr Glu Asn Ala Ile Asp Gln Trp Leu Lys 
        515                 520                 525             


Thr His Met Asn Pro Arg Ala Val 
    530                 535     


<210>  815
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ART1__Homo_sapiens__NP_004305

<400>  815

Met Gln Met Pro Ala Met Met Ser Leu Leu Leu Val Ser Val Gly Leu 
1               5                   10                  15      


Met Glu Ala Leu Gln Ala Gln Ser His Pro Ile Thr Arg Arg Asp Leu 
            20                  25                  30          


Phe Ser Gln Glu Ile Gln Leu Asp Met Ala Leu Ala Ser Phe Asp Asp 
        35                  40                  45              


Gln Tyr Ala Gly Cys Ala Ala Ala Met Thr Ala Ala Leu Pro Asp Leu 
    50                  55                  60                  


Asn His Thr Glu Phe Gln Ala Asn Gln Val Tyr Ala Asp Ser Trp Thr 
65                  70                  75                  80  


Leu Ala Ser Ser Gln Trp Gln Glu Arg Gln Ala Arg Trp Pro Glu Trp 
                85                  90                  95      


Ser Leu Ser Pro Thr Arg Pro Ser Pro Pro Pro Leu Gly Phe Arg Asp 
            100                 105                 110         


Glu His Gly Val Ala Leu Leu Ala Tyr Thr Ala Asn Ser Pro Leu His 
        115                 120                 125             


Lys Glu Phe Asn Ala Ala Val Arg Glu Ala Gly Arg Ser Arg Ala His 
    130                 135                 140                 


Tyr Leu His His Phe Ser Phe Lys Thr Leu His Phe Leu Leu Thr Glu 
145                 150                 155                 160 


Ala Leu Gln Leu Leu Gly Ser Gly Gln Arg Pro Pro Arg Cys His Gln 
                165                 170                 175     


Val Phe Arg Gly Val His Gly Leu Arg Phe Arg Pro Ala Gly Pro Arg 
            180                 185                 190         


Ala Thr Val Arg Leu Gly Gly Phe Ala Ser Ala Ser Leu Lys His Val 
        195                 200                 205             


Ala Ala Gln Gln Phe Gly Glu Asp Thr Phe Phe Gly Ile Trp Thr Cys 
    210                 215                 220                 


Leu Gly Ala Pro Ile Lys Gly Tyr Ser Phe Phe Pro Gly Glu Glu Glu 
225                 230                 235                 240 


Val Leu Ile Pro Pro Phe Glu Thr Phe Gln Val Ile Asn Ala Ser Arg 
                245                 250                 255     


Leu Ala Gln Gly Pro Ala Arg Ile Tyr Leu Arg Ala Leu Gly Lys His 
            260                 265                 270         


Ser Thr Tyr Asn Cys Glu Tyr Ile Lys Asp Lys Lys Cys Lys Ser Gly 
        275                 280                 285             


Pro Cys His Leu Asp Asn Ser Ala Met Gly Gln Ser Pro Leu Ser Ala 
    290                 295                 300                 


Val Trp Ser Leu Leu Leu Leu Leu Trp Phe Leu Val Val Arg Ala Phe 
305                 310                 315                 320 


Pro Asp Gly Pro Gly Leu Leu 
                325         


<210>  816
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ART3__Homo_sapiens__NP_001123488

<400>  816

Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met 
1               5                   10                  15      


Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala 
            20                  25                  30          


Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu 
        35                  40                  45              


Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln 
    50                  55                  60                  


Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg 
65                  70                  75                  80  


Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile 
                85                  90                  95      


Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr 
            100                 105                 110         


His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp 
        115                 120                 125             


Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg 
    130                 135                 140                 


Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val 
145                 150                 155                 160 


Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn 
                165                 170                 175     


Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln 
            180                 185                 190         


Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly 
        195                 200                 205             


Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu 
    210                 215                 220                 


Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn 
225                 230                 235                 240 


Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys 
                245                 250                 255     


Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu 
            260                 265                 270         


Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys 
        275                 280                 285             


Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu 
    290                 295                 300                 


Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr 
305                 310                 315                 320 


Gln Ile Pro Gly Met Lys Ile Pro Glu Pro Phe Pro Leu Pro Glu Asp 
                325                 330                 335     


Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro Gly Pro Val Pro Val 
            340                 345                 350         


Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser Gly Lys Leu Leu Leu 
        355                 360                 365             


Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser Val Ser Ala Ile Asn 
    370                 375                 380                 


Leu Phe Val Ala Leu 
385                 


<210>  817
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ART4__Homo_sapiens__NP_066549

<400>  817

Met Gly Pro Leu Ile Asn Arg Cys Lys Lys Ile Leu Leu Pro Thr Thr 
1               5                   10                  15      


Val Pro Pro Ala Thr Met Arg Ile Trp Leu Leu Gly Gly Leu Leu Pro 
            20                  25                  30          


Phe Leu Leu Leu Leu Ser Gly Leu Gln Arg Pro Thr Glu Gly Ser Glu 
        35                  40                  45              


Val Ala Ile Lys Ile Asp Phe Asp Phe Ala Pro Gly Ser Phe Asp Asp 
    50                  55                  60                  


Gln Tyr Gln Gly Cys Ser Lys Gln Val Met Glu Lys Leu Thr Gln Gly 
65                  70                  75                  80  


Asp Tyr Phe Thr Lys Asp Ile Glu Ala Gln Lys Asn Tyr Phe Arg Met 
                85                  90                  95      


Trp Gln Lys Ala His Leu Ala Trp Leu Asn Gln Gly Lys Val Leu Pro 
            100                 105                 110         


Gln Asn Met Thr Thr Thr His Ala Val Ala Ile Leu Phe Tyr Thr Leu 
        115                 120                 125             


Asn Ser Asn Val His Ser Asp Phe Thr Arg Ala Met Ala Ser Val Ala 
    130                 135                 140                 


Arg Thr Pro Gln Gln Tyr Glu Arg Ser Phe His Phe Lys Tyr Leu His 
145                 150                 155                 160 


Tyr Tyr Leu Thr Ser Ala Ile Gln Leu Leu Arg Lys Asp Ser Ile Met 
                165                 170                 175     


Glu Asn Gly Thr Leu Cys Tyr Glu Val His Tyr Arg Thr Lys Asp Val 
            180                 185                 190         


His Phe Asn Ala Tyr Thr Gly Ala Thr Ile Arg Phe Gly Gln Phe Leu 
        195                 200                 205             


Ser Thr Ser Leu Leu Lys Glu Glu Ala Gln Glu Phe Gly Asn Gln Thr 
    210                 215                 220                 


Leu Phe Thr Ile Phe Thr Cys Leu Gly Ala Pro Val Gln Tyr Phe Ser 
225                 230                 235                 240 


Leu Lys Lys Glu Val Leu Ile Pro Pro Tyr Glu Leu Phe Lys Val Ile 
                245                 250                 255     


Asn Met Ser Tyr His Pro Arg Gly Asp Trp Leu Gln Leu Arg Ser Thr 
            260                 265                 270         


Gly Asn Leu Ser Thr Tyr Asn Cys Gln Leu Leu Lys Ala Ser Ser Lys 
        275                 280                 285             


Lys Cys Ile Pro Asp Pro Ile Ala Ile Ala Ser Leu Ser Phe Leu Thr 
    290                 295                 300                 


Ser Val Ile Ile Phe Ser Lys Ser Arg Val 
305                 310                 


<210>  818
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARVCF__Homo_sapiens__XP_005261300

<400>  818

Met Glu Asp Cys Asn Val His Ser Ala Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Arg Phe Glu Arg Leu Thr Arg Ala Leu Glu Gln 
            20                  25                  30          


Glu Arg Arg His Val Ala Leu Gln Leu Glu Arg Ala Gln Gln Pro Gly 
        35                  40                  45              


Met Val Ser Gly Gly Met Gly Ser Gly Gln Pro Leu Pro Met Ala Trp 
    50                  55                  60                  


Gln Gln Leu Val Leu Gln Glu Gln Ser Pro Gly Ser Gln Ala Ser Leu 
65                  70                  75                  80  


Ala Thr Met Pro Glu Ala Pro Asp Val Leu Glu Glu Thr Val Thr Val 
                85                  90                  95      


Glu Glu Asp Pro Gly Thr Pro Thr Ser His Val Ser Ile Val Thr Ser 
            100                 105                 110         


Glu Asp Gly Thr Thr Arg Arg Thr Glu Thr Lys Val Thr Lys Thr Val 
        115                 120                 125             


Lys Thr Val Thr Thr Arg Thr Val Arg Gln Val Pro Val Gly Pro Asp 
    130                 135                 140                 


Gly Leu Pro Leu Leu Asp Gly Gly Pro Pro Leu Gly Pro Phe Ala Asp 
145                 150                 155                 160 


Gly Ala Leu Asp Arg His Phe Leu Leu Arg Gly Gly Gly Pro Val Ala 
                165                 170                 175     


Thr Leu Ser Arg Ala Tyr Leu Ser Ser Gly Gly Gly Phe Pro Glu Gly 
            180                 185                 190         


Pro Glu Pro Arg Asp Ser Pro Ser Tyr Gly Ser Leu Ser Arg Gly Leu 
        195                 200                 205             


Gly Met Arg Pro Pro Arg Ala Gly Pro Leu Gly Pro Gly Pro Gly Asp 
    210                 215                 220                 


Gly Cys Phe Thr Leu Pro Gly His Arg Glu Ala Phe Pro Val Gly Pro 
225                 230                 235                 240 


Glu Pro Gly Pro Pro Gly Gly Arg Ser Leu Pro Glu Arg Phe Gln Ala 
                245                 250                 255     


Glu Pro Tyr Gly Leu Glu Asp Asp Thr Arg Ser Leu Ala Ala Asp Asp 
            260                 265                 270         


Glu Gly Gly Pro Glu Leu Glu Pro Asp Tyr Gly Thr Ala Thr Arg Arg 
        275                 280                 285             


Arg Pro Glu Cys Gly Arg Gly Leu His Thr Arg Ala Tyr Glu Asp Thr 
    290                 295                 300                 


Ala Asp Asp Gly Gly Glu Leu Ala Asp Glu Arg Pro Ala Phe Pro Met 
305                 310                 315                 320 


Val Thr Ala Pro Leu Ala Gln Pro Glu Arg Gly Ser Met Gly Ser Leu 
                325                 330                 335     


Asp Arg Leu Val Arg Arg Ser Pro Ser Val Asp Ser Ala Arg Lys Glu 
            340                 345                 350         


Pro Arg Trp Arg Asp Pro Glu Leu Pro Glu Val Leu Ala Met Leu Arg 
        355                 360                 365             


His Pro Val Asp Pro Val Lys Ala Asn Ala Ala Ala Tyr Leu Gln His 
    370                 375                 380                 


Leu Cys Phe Glu Asn Glu Gly Val Lys Arg Arg Val Arg Gln Leu Arg 
385                 390                 395                 400 


Gly Leu Pro Leu Leu Val Ala Leu Leu Asp His Pro Arg Ala Glu Val 
                405                 410                 415     


Arg Arg Arg Ala Cys Gly Ala Leu Arg Asn Leu Ser Tyr Gly Arg Asp 
            420                 425                 430         


Thr Asp Asn Lys Ala Ala Ile Arg Asp Cys Gly Gly Val Pro Ala Leu 
        435                 440                 445             


Val Arg Leu Leu Arg Ala Ala Arg Asp Asn Glu Val Arg Glu Leu Val 
    450                 455                 460                 


Thr Gly Thr Leu Trp Asn Leu Ser Ser Tyr Glu Pro Leu Lys Met Val 
465                 470                 475                 480 


Ile Ile Asp His Gly Leu Gln Thr Leu Thr His Glu Val Ile Val Pro 
                485                 490                 495     


His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Ser Lys Pro Arg Asp 
            500                 505                 510         


Ala Glu Trp Thr Thr Val Phe Lys Asn Thr Ser Gly Cys Leu Arg Asn 
        515                 520                 525             


Val Ser Ser Asp Gly Ala Glu Ala Arg Arg Arg Leu Arg Glu Cys Glu 
    530                 535                 540                 


Gly Leu Val Asp Ala Leu Leu His Ala Leu Gln Ser Ala Val Gly Arg 
545                 550                 555                 560 


Lys Asp Thr Asp Asn Lys Ser Val Glu Asn Cys Val Cys Ile Met Arg 
                565                 570                 575     


Asn Leu Ser Tyr His Val His Lys Glu Val Pro Gly Ala Asp Arg Tyr 
            580                 585                 590         


Gln Glu Ala Glu Pro Gly Pro Leu Gly Ser Ala Val Gly Ser Gln Arg 
        595                 600                 605             


Arg Arg Arg Asp Asp Ala Ser Cys Phe Gly Gly Lys Lys Ala Lys Gly 
    610                 615                 620                 


Lys Lys Asp Gly Glu Met Asp Arg Asn Phe Asp Thr Leu Asp Leu Pro 
625                 630                 635                 640 


Lys Arg Thr Glu Ala Ala Lys Gly Phe Glu Leu Leu Tyr Gln Pro Glu 
                645                 650                 655     


Val Val Arg Leu Tyr Leu Ser Leu Leu Thr Glu Ser Arg Asn Phe Asn 
            660                 665                 670         


Thr Leu Glu Ala Ala Ala Gly Ala Leu Gln Asn Leu Ser Ala Gly Asn 
        675                 680                 685             


Trp Met Trp Ala Thr Tyr Ile Arg Ala Thr Val Arg Lys Glu Arg Gly 
    690                 695                 700                 


Leu Pro Val Leu Val Glu Leu Leu Gln Ser Glu Thr Asp Lys Val Val 
705                 710                 715                 720 


Arg Ala Val Ala Ile Ala Leu Arg Asn Leu Ser Leu Asp Arg Arg Asn 
                725                 730                 735     


Lys Asp Leu Ile Gly Ser Tyr Ala Met Ala Glu Leu Val Arg Asn Val 
            740                 745                 750         


Arg Asn Ala Gln Ala Pro Pro Arg Pro Gly Ala Cys Leu Glu Glu Asp 
        755                 760                 765             


Thr Val Val Ala Val Leu Asn Thr Ile His Glu Ile Val Ser Asp Ser 
    770                 775                 780                 


Leu Asp Asn Ala Arg Ser Leu Leu Gln Ala Arg Gly Val Pro Ala Leu 
785                 790                 795                 800 


Val Ala Leu Val Ala Ser Ser Gln Ser Val Arg Glu Ala Lys Ala Ala 
                805                 810                 815     


Ser His Val Leu Gln Thr Val Trp Ser Tyr Lys Glu Leu Arg Gly Thr 
            820                 825                 830         


Leu Gln Lys Asp Gly Trp Thr Lys Ala Arg Phe Gln Ser Ala Ala Ala 
        835                 840                 845             


Thr Ala Lys Gly Pro Lys Gly Ala Leu Ser Pro Gly Gly Phe Asp Asp 
    850                 855                 860                 


Ser Thr Leu Pro Leu Val Asp Lys Ser Leu Glu Gly Glu Lys Thr Gly 
865                 870                 875                 880 


Ser Arg Asp Val Ile Pro Met Asp Ala Leu Gly Pro Asp Gly Tyr Ser 
                885                 890                 895     


Thr Val Asp Arg Arg Glu Arg Arg Pro Arg Gly Ala Ser Ser Ala Gly 
            900                 905                 910         


Glu Ala Ser Glu Lys Glu Pro Leu Lys Leu Asp Pro Ser Arg Lys Ala 
        915                 920                 925             


Pro Pro Pro Gly Pro Ser Arg Pro Ala Val Arg Leu Val Asp Ala Val 
    930                 935                 940                 


Gly Asp Ala Lys Pro Gln Pro Val Asp Ser Trp Val 
945                 950                 955     


<210>  819
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARX__Homo_sapiens__NP_620689

<400>  819

Met Ser Asn Gln Tyr Gln Glu Glu Gly Cys Ser Glu Arg Pro Glu Cys 
1               5                   10                  15      


Lys Ser Lys Ser Pro Thr Leu Leu Ser Ser Tyr Cys Ile Asp Ser Ile 
            20                  25                  30          


Leu Gly Arg Arg Ser Pro Cys Lys Met Arg Leu Leu Gly Ala Ala Gln 
        35                  40                  45              


Ser Leu Pro Ala Pro Leu Thr Ser Arg Ala Asp Pro Glu Lys Ala Val 
    50                  55                  60                  


Gln Gly Ser Pro Lys Ser Ser Ser Ala Pro Phe Glu Ala Glu Leu His 
65                  70                  75                  80  


Leu Pro Pro Lys Leu Arg Arg Leu Tyr Gly Pro Gly Gly Gly Arg Leu 
                85                  90                  95      


Leu Gln Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Thr Ala Thr Ala Gly Pro Arg Gly Glu Ala Pro Pro Pro 
        115                 120                 125             


Pro Pro Pro Thr Ala Arg Pro Gly Glu Arg Pro Asp Gly Ala Gly Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Trp Asp Thr Leu Lys 
145                 150                 155                 160 


Ile Ser Gln Ala Pro Gln Val Ser Ile Ser Arg Ser Lys Ser Tyr Arg 
                165                 170                 175     


Glu Asn Gly Ala Pro Phe Val Pro Pro Pro Pro Ala Leu Asp Glu Leu 
            180                 185                 190         


Gly Gly Pro Gly Gly Val Thr His Pro Glu Glu Arg Leu Gly Val Ala 
        195                 200                 205             


Gly Gly Pro Gly Ser Ala Pro Ala Ala Gly Gly Gly Thr Gly Thr Glu 
    210                 215                 220                 


Asp Asp Glu Glu Glu Leu Leu Glu Asp Glu Glu Asp Glu Asp Glu Glu 
225                 230                 235                 240 


Glu Glu Leu Leu Glu Asp Asp Glu Glu Glu Leu Leu Glu Asp Asp Ala 
                245                 250                 255     


Arg Ala Leu Leu Lys Glu Pro Arg Arg Cys Pro Val Ala Ala Thr Gly 
            260                 265                 270         


Ala Val Ala Ala Ala Ala Ala Ala Ala Val Ala Thr Glu Gly Gly Glu 
        275                 280                 285             


Leu Ser Pro Lys Glu Glu Leu Leu Leu His Pro Glu Asp Ala Glu Gly 
    290                 295                 300                 


Lys Asp Gly Glu Asp Ser Val Cys Leu Ser Ala Gly Ser Asp Ser Glu 
305                 310                 315                 320 


Glu Gly Leu Leu Lys Arg Lys Gln Arg Arg Tyr Arg Thr Thr Phe Thr 
                325                 330                 335     


Ser Tyr Gln Leu Glu Glu Leu Glu Arg Ala Phe Gln Lys Thr His Tyr 
            340                 345                 350         


Pro Asp Val Phe Thr Arg Glu Glu Leu Ala Met Arg Leu Asp Leu Thr 
        355                 360                 365             


Glu Ala Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg 
    370                 375                 380                 


Lys Arg Glu Lys Ala Gly Ala Gln Thr His Pro Pro Gly Leu Pro Phe 
385                 390                 395                 400 


Pro Gly Pro Leu Ser Ala Thr His Pro Leu Ser Pro Tyr Leu Asp Ala 
                405                 410                 415     


Ser Pro Phe Pro Pro His His Pro Ala Leu Asp Ser Ala Trp Thr Ala 
            420                 425                 430         


Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Ser Leu Pro Pro Pro Pro 
        435                 440                 445             


Gly Ser Ala Ser Leu Pro Pro Ser Gly Ala Pro Leu Gly Leu Ser Thr 
    450                 455                 460                 


Phe Leu Gly Ala Ala Val Phe Arg His Pro Ala Phe Ile Ser Pro Ala 
465                 470                 475                 480 


Phe Gly Arg Leu Phe Ser Thr Met Ala Pro Leu Thr Ser Ala Ser Thr 
                485                 490                 495     


Ala Ala Ala Leu Leu Arg Gln Pro Thr Pro Ala Val Glu Gly Ala Val 
            500                 505                 510         


Ala Ser Gly Ala Leu Ala Asp Pro Ala Thr Ala Ala Ala Asp Arg Arg 
        515                 520                 525             


Ala Ser Ser Ile Ala Ala Leu Arg Leu Lys Ala Lys Glu His Ala Ala 
    530                 535                 540                 


Gln Leu Thr Gln Leu Asn Ile Leu Pro Gly Thr Ser Thr Gly Lys Glu 
545                 550                 555                 560 


Val Cys 
        


<210>  820
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS3MT__Homo_sapiens__NP_065733

<400>  820

Met Ala Ala Leu Arg Asp Ala Glu Ile Gln Lys Asp Val Gln Thr Tyr 
1               5                   10                  15      


Tyr Gly Gln Val Leu Lys Arg Ser Ala Asp Leu Gln Thr Asn Gly Cys 
            20                  25                  30          


Val Thr Thr Ala Arg Pro Val Pro Lys His Ile Arg Glu Ala Leu Gln 
        35                  40                  45              


Asn Val His Glu Glu Val Ala Leu Arg Tyr Tyr Gly Cys Gly Leu Val 
    50                  55                  60                  


Ile Pro Glu His Leu Glu Asn Cys Trp Ile Leu Asp Leu Gly Ser Gly 
65                  70                  75                  80  


Ser Gly Arg Asp Cys Tyr Val Leu Ser Gln Leu Val Gly Glu Lys Gly 
                85                  90                  95      


His Val Thr Gly Ile Asp Met Thr Lys Gly Gln Val Glu Val Ala Glu 
            100                 105                 110         


Lys Tyr Leu Asp Tyr His Met Glu Lys Tyr Gly Phe Gln Ala Ser Asn 
        115                 120                 125             


Val Thr Phe Ile His Gly Tyr Ile Glu Lys Leu Gly Glu Ala Gly Ile 
    130                 135                 140                 


Lys Asn Glu Ser His Asp Ile Val Val Ser Asn Cys Val Ile Asn Leu 
145                 150                 155                 160 


Val Pro Asp Lys Gln Gln Val Leu Gln Glu Ala Tyr Arg Val Leu Lys 
                165                 170                 175     


His Gly Gly Glu Leu Tyr Phe Ser Asp Val Tyr Thr Ser Leu Glu Leu 
            180                 185                 190         


Pro Glu Glu Ile Arg Thr His Lys Val Leu Trp Gly Glu Cys Leu Gly 
        195                 200                 205             


Gly Ala Leu Tyr Trp Lys Glu Leu Ala Val Leu Ala Gln Lys Ile Gly 
    210                 215                 220                 


Phe Cys Pro Pro Arg Leu Val Thr Ala Asn Leu Ile Thr Ile Gln Asn 
225                 230                 235                 240 


Lys Glu Leu Glu Arg Val Ile Gly Asp Cys Arg Phe Val Ser Ala Thr 
                245                 250                 255     


Phe Arg Leu Phe Lys His Ser Lys Thr Gly Pro Thr Lys Arg Cys Gln 
            260                 265                 270         


Val Ile Tyr Asn Gly Gly Ile Thr Gly His Glu Lys Glu Leu Met Phe 
        275                 280                 285             


Asp Ala Asn Phe Thr Phe Lys Glu Gly Glu Ile Val Glu Val Asp Glu 
    290                 295                 300                 


Glu Thr Ala Ala Ile Leu Lys Asn Ser Arg Phe Ala Gln Asp Phe Leu 
305                 310                 315                 320 


Ile Arg Pro Ile Gly Glu Lys Leu Pro Thr Ser Gly Gly Cys Ser Ala 
                325                 330                 335     


Leu Glu Leu Lys Asp Ile Ile Thr Asp Pro Phe Lys Leu Ala Glu Glu 
            340                 345                 350         


Ser Asp Ser Met Lys Ser Arg Cys Val Pro Asp Ala Ala Gly Gly Cys 
        355                 360                 365             


Cys Gly Thr Lys Lys Ser Cys 
    370                 375 


<210>  821
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASAH1__Homo_sapiens__NP_001120977

<400>  821

Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Val Phe Pro Ala Val Ile 
    50                  55                  60                  


Arg Tyr Arg Gly Ala Val Pro Trp Tyr Thr Ile Asn Leu Asp Leu Pro 
65                  70                  75                  80  


Pro Tyr Lys Arg Trp His Glu Leu Met Leu Asp Lys Ala Pro Val Pro 
                85                  90                  95      


Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe Glu Glu Glu Met Lys Gly 
            100                 105                 110         


Ile Ala Ala Val Thr Asp Ile Pro Leu Gly Glu Ile Ile Ser Phe Asn 
        115                 120                 125             


Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr Ser Ile Val Ala Glu Asp 
    130                 135                 140                 


Lys Lys Gly His Leu Ile His Gly Arg Asn Met Asp Phe Gly Val Phe 
145                 150                 155                 160 


Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp Val Ile Thr Glu Gln Leu 
                165                 170                 175     


Lys Pro Leu Thr Val Asn Leu Asp Phe Gln Arg Asn Asn Lys Thr Val 
            180                 185                 190         


Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val Gly Met Leu Thr Gly Phe 
        195                 200                 205             


Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn Glu Arg Phe Ser Ile Asn 
    210                 215                 220                 


Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile Leu Gly Lys Lys Asp Val 
225                 230                 235                 240 


Met Trp Ile Gly Phe Leu Thr Arg Thr Val Leu Glu Asn Ser Thr Ser 
                245                 250                 255     


Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys Thr Lys Ile Leu Ala Pro 
            260                 265                 270         


Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser Gly Glu Gly Cys Val Ile 
        275                 280                 285             


Thr Arg Asp Arg Lys Glu Ser Leu Asp Val Tyr Glu Leu Asp Ala Lys 
    290                 295                 300                 


Gln Gly Arg Trp Tyr Val Val Gln Thr Asn Tyr Asp Arg Trp Lys His 
305                 310                 315                 320 


Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro Ala Lys Met Cys Leu Asn 
                325                 330                 335     


Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu Thr Met Tyr Asp Val Leu 
            340                 345                 350         


Ser Thr Lys Pro Val Leu Asn Lys Leu Thr Val Tyr Thr Thr Leu Ile 
        355                 360                 365             


Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr Leu Arg Asp Cys Pro Asp 
    370                 375                 380                 


Pro Cys Ile Gly Trp 
385                 


<210>  822
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASAH2__Homo_sapiens__NP_001137446

<400>  822

Met Ala Lys Arg Thr Phe Ser Asn Leu Glu Thr Phe Leu Ile Phe Leu 
1               5                   10                  15      


Leu Val Met Met Ser Ala Ile Thr Val Ala Leu Leu Ser Leu Leu Phe 
            20                  25                  30          


Ile Thr Ser Gly Thr Ile Glu Asn His Lys Asp Leu Gly Gly His Phe 
        35                  40                  45              


Phe Ser Thr Thr Gln Ser Pro Pro Ala Thr Gln Gly Ser Thr Ala Ala 
    50                  55                  60                  


Gln Arg Ser Thr Ala Thr Gln His Ser Thr Ala Thr Gln Ser Ser Thr 
65                  70                  75                  80  


Ala Thr Gln Thr Ser Pro Val Pro Leu Thr Pro Glu Ser Pro Leu Phe 
                85                  90                  95      


Gln Asn Phe Ser Gly Tyr His Ile Gly Val Gly Arg Ala Asp Cys Thr 
            100                 105                 110         


Gly Gln Val Ala Asp Ile Asn Leu Met Gly Tyr Gly Lys Ser Gly Gln 
        115                 120                 125             


Asn Ala Gln Gly Ile Leu Thr Arg Leu Tyr Ser Arg Ala Phe Ile Met 
    130                 135                 140                 


Ala Glu Pro Asp Gly Ser Asn Arg Thr Val Phe Val Ser Ile Asp Ile 
145                 150                 155                 160 


Gly Met Val Ser Gln Arg Leu Arg Leu Glu Val Leu Asn Arg Leu Gln 
                165                 170                 175     


Ser Lys Tyr Gly Ser Leu Tyr Arg Arg Asp Asn Val Ile Leu Ser Gly 
            180                 185                 190         


Thr His Thr His Ser Gly Pro Ala Gly Tyr Phe Gln Tyr Thr Val Phe 
        195                 200                 205             


Val Ile Ala Ser Glu Gly Phe Ser Asn Gln Thr Phe Gln His Met Val 
    210                 215                 220                 


Thr Gly Ile Leu Lys Ser Ile Asp Ile Ala His Thr Asn Met Lys Pro 
225                 230                 235                 240 


Gly Lys Ile Phe Ile Asn Lys Gly Asn Val Asp Gly Val Gln Ile Asn 
                245                 250                 255     


Arg Ser Pro Tyr Ser Tyr Leu Gln Asn Pro Gln Ser Glu Arg Ala Arg 
            260                 265                 270         


Tyr Ser Ser Asn Thr Asp Lys Glu Met Ile Val Leu Lys Met Val Asp 
        275                 280                 285             


Leu Asn Gly Asp Asp Leu Gly Leu Ile Ser Trp Phe Ala Ile His Pro 
    290                 295                 300                 


Val Ser Met Asn Asn Ser Asn His Leu Val Asn Ser Asp Asn Val Gly 
305                 310                 315                 320 


Tyr Ala Ser Tyr Leu Leu Glu Gln Glu Lys Asn Lys Gly Tyr Leu Pro 
                325                 330                 335     


Gly Gln Gly Pro Phe Val Ala Ala Phe Ala Ser Ser Asn Leu Gly Asp 
            340                 345                 350         


Val Ser Pro Asn Ile Leu Gly Pro Arg Cys Ile Asn Thr Gly Glu Ser 
        355                 360                 365             


Cys Asp Asn Ala Asn Ser Thr Cys Pro Ile Gly Gly Pro Ser Met Cys 
    370                 375                 380                 


Ile Ala Lys Gly Pro Gly Gln Asp Met Phe Asp Ser Thr Gln Ile Ile 
385                 390                 395                 400 


Gly Arg Ala Met Tyr Gln Arg Ala Lys Ser Lys Thr Cys Lys Pro Ala 
                405                 410                 415     


Leu Gly Tyr Ser Phe Ala Ala Gly Thr Ile Asp Gly Val Gly Gly Leu 
            420                 425                 430         


Asn Phe Thr Gln Gly Lys Thr Glu Gly Asp Pro Phe Trp Asp Thr Ile 
        435                 440                 445             


Arg Asp Gln Ile Leu Gly Lys Pro Ser Glu Glu Ile Lys Glu Cys His 
    450                 455                 460                 


Lys Pro Lys Pro Ile Leu Leu His Thr Gly Glu Leu Ser Lys Pro His 
465                 470                 475                 480 


Pro Trp His Pro Asp Ile Val Asp Val Gln Ile Ile Thr Leu Gly Ser 
                485                 490                 495     


Leu Ala Ile Thr Ala Ile Pro Gly Glu Phe Thr Thr Met Ser Gly Arg 
            500                 505                 510         


Arg Leu Arg Glu Ala Val Gln Ala Glu Phe Ala Ser His Gly Met Gln 
        515                 520                 525             


Asn Met Thr Val Val Ile Ser Gly Leu Cys Asn Val Tyr Thr His Tyr 
    530                 535                 540                 


Ile Thr Thr Tyr Glu Glu Tyr Gln Ala Gln Arg Tyr Glu Ala Ala Ser 
545                 550                 555                 560 


Thr Ile Tyr Gly Pro His Thr Leu Ser Ala Tyr Ile Gln Leu Phe Arg 
                565                 570                 575     


Asn Leu Ala Lys Ala Ile Ala Thr Asp Thr Val Ala Asn Leu Ser Arg 
            580                 585                 590         


Gly Pro Glu Pro Pro Phe Phe Lys Gln Leu Ile Val Pro Leu Ile Pro 
        595                 600                 605             


Ser Ile Val Asp Arg Ala Pro Lys Gly Arg Thr Phe Gly Asp Val Leu 
    610                 615                 620                 


Gln Pro Ala Lys Pro Glu Tyr Arg Val Gly Glu Val Ala Glu Val Ile 
625                 630                 635                 640 


Phe Val Gly Ala Asn Pro Lys Asn Ser Val Gln Asn Gln Thr His Gln 
                645                 650                 655     


Thr Phe Leu Thr Val Glu Lys Tyr Glu Ala Thr Ser Thr Ser Trp Gln 
            660                 665                 670         


Ile Val Cys Asn Asp Ala Ser Trp Glu Thr Arg Phe Tyr Trp His Lys 
        675                 680                 685             


Gly Leu Leu Gly Leu Ser Asn Ala Thr Val Glu Trp His Ile Pro Asp 
    690                 695                 700                 


Thr Ala Gln Pro Gly Ile Tyr Arg Ile Arg Tyr Phe Gly His Asn Arg 
705                 710                 715                 720 


Lys Gln Asp Ile Leu Lys Pro Ala Val Ile Leu Ser Phe Glu Gly Thr 
                725                 730                 735     


Ser Pro Ala Phe Glu Val Val Thr Ile 
            740                 745 


<210>  823
<211>  1129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASAP1__Homo_sapiens__NP_060952

<400>  823

Met Arg Ser Ser Ala Ser Arg Leu Ser Ser Phe Ser Ser Arg Asp Ser 
1               5                   10                  15      


Leu Trp Asn Arg Met Pro Asp Gln Ile Ser Val Ser Glu Phe Ile Ala 
            20                  25                  30          


Glu Thr Thr Glu Asp Tyr Asn Ser Pro Thr Thr Ser Ser Phe Thr Thr 
        35                  40                  45              


Arg Leu His Asn Cys Arg Asn Thr Val Thr Leu Leu Glu Glu Ala Leu 
    50                  55                  60                  


Asp Gln Asp Arg Thr Ala Leu Gln Lys Val Lys Lys Ser Val Lys Ala 
65                  70                  75                  80  


Ile Tyr Asn Ser Gly Gln Asp His Val Gln Asn Glu Glu Asn Tyr Ala 
                85                  90                  95      


Gln Val Leu Asp Lys Phe Gly Ser Asn Phe Leu Ser Arg Asp Asn Pro 
            100                 105                 110         


Asp Leu Gly Thr Ala Phe Val Lys Phe Ser Thr Leu Thr Lys Glu Leu 
        115                 120                 125             


Ser Thr Leu Leu Lys Asn Leu Leu Gln Gly Leu Ser His Asn Val Ile 
    130                 135                 140                 


Phe Thr Leu Asp Ser Leu Leu Lys Gly Asp Leu Lys Gly Val Lys Gly 
145                 150                 155                 160 


Asp Leu Lys Lys Pro Phe Asp Lys Ala Trp Lys Asp Tyr Glu Thr Lys 
                165                 170                 175     


Phe Thr Lys Ile Glu Lys Glu Lys Arg Glu His Ala Lys Gln His Gly 
            180                 185                 190         


Met Ile Arg Thr Glu Ile Thr Gly Ala Glu Ile Ala Glu Glu Met Glu 
        195                 200                 205             


Lys Glu Arg Arg Leu Phe Gln Leu Gln Met Cys Glu Tyr Leu Ile Lys 
    210                 215                 220                 


Val Asn Glu Ile Lys Thr Lys Lys Gly Val Asp Leu Leu Gln Asn Leu 
225                 230                 235                 240 


Ile Lys Tyr Tyr His Ala Gln Cys Asn Phe Phe Gln Asp Gly Leu Lys 
                245                 250                 255     


Thr Ala Asp Lys Leu Lys Gln Tyr Ile Glu Lys Leu Ala Ala Asp Leu 
            260                 265                 270         


Tyr Asn Ile Lys Gln Thr Gln Asp Glu Glu Lys Lys Gln Leu Thr Ala 
        275                 280                 285             


Leu Arg Asp Leu Ile Lys Ser Ser Leu Gln Leu Asp Gln Lys Glu Asp 
    290                 295                 300                 


Ser Gln Ser Arg Gln Gly Gly Tyr Ser Met His Gln Leu Gln Gly Asn 
305                 310                 315                 320 


Lys Glu Tyr Gly Ser Glu Lys Lys Gly Tyr Leu Leu Lys Lys Ser Asp 
                325                 330                 335     


Gly Ile Arg Lys Val Trp Gln Arg Arg Lys Cys Ser Val Lys Asn Gly 
            340                 345                 350         


Ile Leu Thr Ile Ser His Ala Thr Ser Asn Arg Gln Pro Ala Lys Leu 
        355                 360                 365             


Asn Leu Leu Thr Cys Gln Val Lys Pro Asn Ala Glu Asp Lys Lys Ser 
    370                 375                 380                 


Phe Asp Leu Ile Ser His Asn Arg Thr Tyr His Phe Gln Ala Glu Asp 
385                 390                 395                 400 


Glu Gln Asp Tyr Val Ala Trp Ile Ser Val Leu Thr Asn Ser Lys Glu 
                405                 410                 415     


Glu Ala Leu Thr Met Ala Phe Arg Gly Glu Gln Ser Ala Gly Glu Asn 
            420                 425                 430         


Ser Leu Glu Asp Leu Thr Lys Ala Ile Ile Glu Asp Val Gln Arg Leu 
        435                 440                 445             


Pro Gly Asn Asp Ile Cys Cys Asp Cys Gly Ser Ser Glu Pro Thr Trp 
    450                 455                 460                 


Leu Ser Thr Asn Leu Gly Ile Leu Thr Cys Ile Glu Cys Ser Gly Ile 
465                 470                 475                 480 


His Arg Glu Met Gly Val His Ile Ser Arg Ile Gln Ser Leu Glu Leu 
                485                 490                 495     


Asp Lys Leu Gly Thr Ser Glu Leu Leu Leu Ala Lys Asn Val Gly Asn 
            500                 505                 510         


Asn Ser Phe Asn Asp Ile Met Glu Ala Asn Leu Pro Ser Pro Ser Pro 
        515                 520                 525             


Lys Pro Thr Pro Ser Ser Asp Met Thr Val Arg Lys Glu Tyr Ile Thr 
    530                 535                 540                 


Ala Lys Tyr Val Asp His Arg Phe Ser Arg Lys Thr Cys Ser Thr Ser 
545                 550                 555                 560 


Ser Ala Lys Leu Asn Glu Leu Leu Glu Ala Ile Lys Ser Arg Asp Leu 
                565                 570                 575     


Leu Ala Leu Ile Gln Val Tyr Ala Glu Gly Val Glu Leu Met Glu Pro 
            580                 585                 590         


Leu Leu Glu Pro Gly Gln Glu Leu Gly Glu Thr Ala Leu His Leu Ala 
        595                 600                 605             


Val Arg Thr Ala Asp Gln Thr Ser Leu His Leu Val Asp Phe Leu Val 
    610                 615                 620                 


Gln Asn Cys Gly Asn Leu Asp Lys Gln Thr Ala Leu Gly Asn Thr Val 
625                 630                 635                 640 


Leu His Tyr Cys Ser Met Tyr Ser Lys Pro Glu Cys Leu Lys Leu Leu 
                645                 650                 655     


Leu Arg Ser Lys Pro Thr Val Asp Ile Val Asn Gln Ala Gly Glu Thr 
            660                 665                 670         


Ala Leu Asp Ile Ala Lys Arg Leu Lys Ala Thr Gln Cys Glu Asp Leu 
        675                 680                 685             


Leu Ser Gln Ala Lys Ser Gly Lys Phe Asn Pro His Val His Val Glu 
    690                 695                 700                 


Tyr Glu Trp Asn Leu Arg Gln Glu Glu Ile Asp Glu Ser Asp Asp Asp 
705                 710                 715                 720 


Leu Asp Asp Lys Pro Ser Pro Ile Lys Lys Glu Arg Ser Pro Arg Pro 
                725                 730                 735     


Gln Ser Phe Cys His Ser Ser Ser Ile Ser Pro Gln Asp Lys Leu Ala 
            740                 745                 750         


Leu Pro Gly Phe Ser Thr Pro Arg Asp Lys Gln Arg Leu Ser Tyr Gly 
        755                 760                 765             


Ala Phe Thr Asn Gln Ile Phe Val Ser Thr Ser Thr Asp Ser Pro Thr 
    770                 775                 780                 


Ser Pro Thr Thr Glu Ala Pro Pro Leu Pro Pro Arg Asn Ala Gly Lys 
785                 790                 795                 800 


Gly Pro Thr Gly Pro Pro Ser Thr Leu Pro Leu Ser Thr Gln Thr Ser 
                805                 810                 815     


Ser Gly Ser Ser Thr Leu Ser Lys Lys Arg Pro Pro Pro Pro Pro Pro 
            820                 825                 830         


Gly His Lys Arg Thr Leu Ser Asp Pro Pro Ser Pro Leu Pro His Gly 
        835                 840                 845             


Pro Pro Asn Lys Gly Ala Val Pro Trp Gly Asn Asp Gly Gly Pro Ser 
    850                 855                 860                 


Ser Ser Ser Lys Thr Thr Asn Lys Phe Glu Gly Leu Ser Gln Gln Ser 
865                 870                 875                 880 


Ser Thr Ser Ser Ala Lys Thr Ala Leu Gly Pro Arg Val Leu Pro Lys 
                885                 890                 895     


Leu Pro Gln Lys Val Ala Leu Arg Lys Thr Asp His Leu Ser Leu Asp 
            900                 905                 910         


Lys Ala Thr Ile Pro Pro Glu Ile Phe Gln Lys Ser Ser Gln Leu Ala 
        915                 920                 925             


Glu Leu Pro Gln Lys Pro Pro Pro Gly Asp Leu Pro Pro Lys Pro Thr 
    930                 935                 940                 


Glu Leu Ala Pro Lys Pro Gln Ile Gly Asp Leu Pro Pro Lys Pro Gly 
945                 950                 955                 960 


Glu Leu Pro Pro Lys Pro Gln Leu Gly Asp Leu Pro Pro Lys Pro Gln 
                965                 970                 975     


Leu Ser Asp Leu Pro Pro Lys Pro Gln Met Lys Asp Leu Pro Pro Lys 
            980                 985                 990         


Pro Gln Leu Gly Asp Leu Leu Ala  Lys Ser Gln Thr Gly  Asp Val Ser 
        995                 1000                 1005             


Pro Lys  Ala Gln Gln Pro Ser  Glu Val Thr Leu Lys  Ser His Pro 
    1010                 1015                 1020             


Leu Asp  Leu Ser Pro Asn Val  Gln Ser Arg Asp Ala  Ile Gln Lys 
    1025                 1030                 1035             


Gln Ala  Ser Glu Asp Ser Asn  Asp Leu Thr Pro Thr  Leu Pro Glu 
    1040                 1045                 1050             


Thr Pro  Val Pro Leu Pro Arg  Lys Ile Asn Thr Gly  Lys Asn Lys 
    1055                 1060                 1065             


Val Arg  Arg Val Lys Thr Ile  Tyr Asp Cys Gln Ala  Asp Asn Asp 
    1070                 1075                 1080             


Asp Glu  Leu Thr Phe Ile Glu  Gly Glu Val Ile Ile  Val Thr Gly 
    1085                 1090                 1095             


Glu Glu  Asp Gln Glu Trp Trp  Ile Gly His Ile Glu  Gly Gln Pro 
    1100                 1105                 1110             


Glu Arg  Lys Gly Val Phe Pro  Val Ser Phe Val His  Ile Leu Ser 
    1115                 1120                 1125             


Asp 
    


<210>  824
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASAP2__Homo_sapiens__NP_001128663

<400>  824

Met Pro Asp Gln Ile Ser Val Ser Glu Phe Val Ala Glu Thr His Glu 
1               5                   10                  15      


Asp Tyr Lys Ala Pro Thr Ala Ser Ser Phe Thr Thr Arg Thr Ala Gln 
            20                  25                  30          


Cys Arg Asn Thr Val Ala Ala Ile Glu Glu Ala Leu Asp Val Asp Arg 
        35                  40                  45              


Met Val Leu Tyr Lys Met Lys Lys Ser Val Lys Ala Ile Asn Ser Ser 
    50                  55                  60                  


Gly Leu Ala His Val Glu Asn Glu Glu Gln Tyr Thr Gln Ala Leu Glu 
65                  70                  75                  80  


Lys Phe Gly Gly Asn Cys Val Cys Arg Asp Asp Pro Asp Leu Gly Ser 
                85                  90                  95      


Ala Phe Leu Lys Phe Ser Val Phe Thr Lys Glu Leu Thr Ala Leu Phe 
            100                 105                 110         


Lys Asn Leu Ile Gln Asn Met Asn Asn Ile Ile Ser Phe Pro Leu Asp 
        115                 120                 125             


Ser Leu Leu Lys Gly Asp Leu Lys Gly Val Lys Gly Asp Leu Lys Lys 
    130                 135                 140                 


Pro Phe Asp Lys Ala Trp Lys Asp Tyr Glu Thr Lys Ile Thr Lys Ile 
145                 150                 155                 160 


Glu Lys Glu Lys Lys Glu His Ala Lys Leu His Gly Met Ile Arg Thr 
                165                 170                 175     


Glu Ile Ser Gly Ala Glu Ile Ala Glu Glu Met Glu Lys Glu Arg Arg 
            180                 185                 190         


Phe Phe Gln Leu Gln Met Cys Glu Tyr Leu Leu Lys Val Asn Glu Ile 
        195                 200                 205             


Lys Ile Lys Lys Gly Val Asp Leu Leu Gln Asn Leu Ile Lys Tyr Phe 
    210                 215                 220                 


His Ala Gln Cys Asn Phe Phe Gln Asp Gly Leu Lys Ala Val Glu Ser 
225                 230                 235                 240 


Leu Lys Pro Ser Ile Glu Thr Leu Ser Thr Asp Leu His Thr Ile Lys 
                245                 250                 255     


Gln Ala Gln Asp Glu Glu Arg Arg Gln Leu Ile Gln Leu Arg Asp Ile 
            260                 265                 270         


Leu Lys Ser Ala Leu Gln Val Glu Gln Lys Glu Asp Ser Gln Ile Arg 
        275                 280                 285             


Gln Ser Thr Ala Tyr Ser Leu His Gln Pro Gln Gly Asn Lys Glu His 
    290                 295                 300                 


Gly Thr Glu Arg Asn Gly Ser Leu Tyr Lys Lys Ser Asp Gly Ile Arg 
305                 310                 315                 320 


Lys Val Trp Gln Lys Arg Lys Cys Ser Val Lys Asn Gly Phe Leu Thr 
                325                 330                 335     


Ile Ser His Gly Thr Ala Asn Arg Pro Pro Ala Lys Leu Asn Leu Leu 
            340                 345                 350         


Thr Cys Gln Val Lys Thr Asn Pro Glu Glu Lys Lys Cys Phe Asp Leu 
        355                 360                 365             


Ile Ser His Asp Arg Thr Tyr His Phe Gln Ala Glu Asp Glu Gln Glu 
    370                 375                 380                 


Cys Gln Ile Trp Met Ser Val Leu Gln Asn Ser Lys Glu Glu Ala Leu 
385                 390                 395                 400 


Asn Asn Ala Phe Lys Gly Asp Asp Asn Thr Gly Glu Asn Asn Ile Val 
                405                 410                 415     


Gln Glu Leu Thr Lys Glu Ile Ile Ser Glu Val Gln Arg Met Thr Gly 
            420                 425                 430         


Asn Asp Val Cys Cys Asp Cys Gly Ala Pro Asp Pro Thr Trp Leu Ser 
        435                 440                 445             


Thr Asn Leu Gly Ile Leu Thr Cys Ile Glu Cys Ser Gly Ile His Arg 
    450                 455                 460                 


Glu Leu Gly Val His Tyr Ser Arg Met Gln Ser Leu Thr Leu Asp Val 
465                 470                 475                 480 


Leu Gly Thr Ser Glu Leu Leu Leu Ala Lys Asn Ile Gly Asn Ala Gly 
                485                 490                 495     


Phe Asn Glu Ile Met Glu Cys Cys Leu Pro Ala Glu Asp Ser Val Lys 
            500                 505                 510         


Pro Asn Pro Gly Ser Asp Met Asn Ala Arg Lys Asp Tyr Ile Thr Ala 
        515                 520                 525             


Lys Tyr Ile Glu Arg Arg Tyr Ala Arg Lys Lys His Ala Asp Asn Ala 
    530                 535                 540                 


Ala Lys Leu His Ser Leu Cys Glu Ala Val Lys Thr Arg Asp Ile Phe 
545                 550                 555                 560 


Gly Leu Leu Gln Ala Tyr Ala Asp Gly Val Asp Leu Thr Glu Lys Ile 
                565                 570                 575     


Pro Leu Ala Asn Gly His Glu Pro Asp Glu Thr Ala Leu His Leu Ala 
            580                 585                 590         


Val Arg Ser Val Asp Arg Thr Ser Leu His Ile Val Asp Phe Leu Val 
        595                 600                 605             


Gln Asn Ser Gly Asn Leu Asp Lys Gln Thr Gly Lys Gly Ser Thr Ala 
    610                 615                 620                 


Leu His Tyr Cys Cys Leu Thr Asp Asn Ala Glu Cys Leu Lys Leu Leu 
625                 630                 635                 640 


Leu Arg Gly Lys Ala Ser Ile Glu Ile Ala Asn Glu Ser Gly Glu Thr 
                645                 650                 655     


Pro Leu Asp Ile Ala Lys Arg Leu Lys His Glu His Cys Glu Glu Leu 
            660                 665                 670         


Leu Thr Gln Ala Leu Ser Gly Arg Phe Asn Ser His Val His Val Glu 
        675                 680                 685             


Tyr Glu Trp Arg Leu Leu His Glu Asp Leu Asp Glu Ser Asp Asp Asp 
    690                 695                 700                 


Met Asp Glu Lys Leu Gln Pro Ser Pro Asn Arg Arg Glu Asp Arg Pro 
705                 710                 715                 720 


Ile Ser Phe Tyr Gln Leu Gly Ser Asn Gln Leu Gln Ser Asn Ala Val 
                725                 730                 735     


Ser Leu Ala Arg Asp Ala Ala Asn Leu Ala Lys Glu Lys Gln Arg Ala 
            740                 745                 750         


Phe Met Pro Ser Ile Leu Gln Asn Glu Thr Tyr Gly Ala Leu Leu Ser 
        755                 760                 765             


Gly Ser Pro Pro Pro Ala Gln Pro Ala Ala Pro Ser Thr Thr Ser Ala 
    770                 775                 780                 


Pro Pro Leu Pro Pro Arg Asn Val Gly Lys Asp Pro Leu Thr Pro Thr 
785                 790                 795                 800 


Pro Pro Pro Pro Val Ala Lys Thr Pro Ser Val Met Glu Ala Leu Ser 
                805                 810                 815     


Gln Pro Ser Lys Pro Ala Pro Pro Gly Ile Ser Gln Ile Arg Pro Pro 
            820                 825                 830         


Pro Leu Pro Pro Gln Pro Pro Ser Arg Leu Pro Gln Lys Lys Pro Ala 
        835                 840                 845             


Pro Gly Ala Asp Lys Ser Thr Pro Leu Thr Asn Lys Gly Gln Pro Arg 
    850                 855                 860                 


Gly Pro Val Asp Leu Ser Ala Thr Glu Ala Leu Gly Pro Leu Ser Asn 
865                 870                 875                 880 


Ala Met Val Leu Gln Pro Pro Ala Pro Met Pro Arg Lys Ser Gln Ala 
                885                 890                 895     


Thr Lys Leu Lys Pro Lys Arg Val Lys Ala Leu Tyr Asn Cys Val Ala 
            900                 905                 910         


Asp Asn Pro Asp Glu Leu Thr Phe Ser Glu Gly Asp Val Ile Ile Val 
        915                 920                 925             


Asp Gly Glu Glu Asp Gln Glu Trp Trp Ile Gly His Ile Asp Gly Asp 
    930                 935                 940                 


Pro Gly Arg Lys Gly Ala Phe Pro Val Ser Phe Val His Phe Ile Ala 
945                 950                 955                 960 


Asp 
    


<210>  825
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB10__Homo_sapiens__NP_001135931

<400>  825

Met Leu Met Ser Trp Ser Pro Glu Glu Cys Lys Gly Gln Gly Glu Pro 
1               5                   10                  15      


Leu Asp Asp Arg His Pro Leu Cys Ala Arg Leu Val Glu Lys Pro Ser 
            20                  25                  30          


Arg Gly Ser Glu Glu His Leu Lys Ser Gly Pro Gly Pro Ile Val Thr 
        35                  40                  45              


Arg Thr Ala Ser Gly Pro Ala Leu Ala Phe Trp Gln Ala Val Leu Ala 
    50                  55                  60                  


Gly Asp Val Gly Cys Val Ser Arg Ile Leu Ala Asp Ser Ser Thr Gly 
65                  70                  75                  80  


Leu Ala Pro Asp Ser Val Phe Asp Thr Ser Asp Pro Glu Arg Trp Arg 
                85                  90                  95      


Asp Phe Arg Phe Asn Ile Arg Ala Leu Arg Leu Trp Ser Leu Thr Tyr 
            100                 105                 110         


Glu Glu Glu Leu Thr Thr Pro Leu His Val Ala Ala Ser Arg Gly His 
        115                 120                 125             


Thr Glu Val Leu Arg Leu Leu Leu Arg Arg Arg Ala Arg Pro Asp Ser 
    130                 135                 140                 


Ala Pro Gly Gly Arg Thr Ala Leu His Glu Ala Cys Ala Ala Gly His 
145                 150                 155                 160 


Thr Ala Cys Val His Val Leu Leu Val Ala Gly Ala Asp Pro Asn Ile 
                165                 170                 175     


Ala Asp Gln Asp Gly Lys Arg Pro Leu His Leu Cys Arg Gly Pro Gly 
            180                 185                 190         


Thr Leu Glu Cys Ala Glu Leu Leu Leu Arg Phe Gly Ala Arg Val Asp 
        195                 200                 205             


Gly Arg Ser Glu Glu Glu Glu Glu Thr Pro Leu His Val Ala Ala Arg 
    210                 215                 220                 


Leu Gly His Val Glu Leu Ala Asp Leu Leu Leu Arg Arg Gly Ala Cys 
225                 230                 235                 240 


Pro Asp Ala Arg Asn Ala Glu Gly Trp Thr Pro Leu Leu Ala Ala Cys 
                245                 250                 255     


Asp Val Arg Cys Gln Ser Ile Thr Asp Ala Glu Ala Thr Thr Ala Arg 
            260                 265                 270         


Cys Leu Gln Leu Cys Ser Leu Leu Leu Ser Ala Gly Ala Asp Ala Asp 
        275                 280                 285             


Ala Ala Asp Gln Asp Lys Gln Arg Pro Leu His Leu Ala Cys Arg Arg 
    290                 295                 300                 


Gly His Ala Ala Val Val Glu Leu Leu Leu Ser Cys Gly Val Ser Ala 
305                 310                 315                 320 


Asn Thr Met Asp Tyr Gly Gly His Thr Pro Leu His Cys Ala Leu Gln 
                325                 330                 335     


Gly Pro Ala Ala Ala Leu Ala Gln Ser Pro Glu His Val Val Arg Ala 
            340                 345                 350         


Leu Leu Asn His Gly Ala Val Arg Val Trp Pro Gly Ala Leu Pro Lys 
        355                 360                 365             


Val Leu Glu Arg Trp Ser Thr Cys Pro Arg Thr Ile Glu Val Leu Met 
    370                 375                 380                 


Asn Thr Tyr Ser Val Val Gln Leu Pro Glu Glu Ala Val Gly Leu Val 
385                 390                 395                 400 


Thr Pro Glu Thr Leu Gln Lys His Gln Arg Phe Tyr Ser Ser Leu Phe 
                405                 410                 415     


Ala Leu Val Arg Gln Pro Arg Ser Leu Gln His Leu Ser Arg Cys Ala 
            420                 425                 430         


Leu Arg Ser His Leu Glu Gly Ser Leu Pro Gln Ala Leu Pro Arg Leu 
        435                 440                 445             


Pro Leu Pro Pro Arg Leu Leu Arg Tyr Leu Gln Leu Asp Phe Glu Gly 
    450                 455                 460                 


Val Leu Tyr 
465         


<210>  826
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB13__Homo_sapiens__NP_078977

<400>  826

Met Glu Pro Arg Ala Ala Asp Gly Cys Phe Leu Gly Asp Val Gly Phe 
1               5                   10                  15      


Trp Val Glu Arg Thr Pro Val His Glu Ala Ala Gln Arg Gly Glu Ser 
            20                  25                  30          


Leu Gln Leu Gln Gln Leu Ile Glu Ser Gly Ala Cys Val Asn Gln Val 
        35                  40                  45              


Thr Val Asp Ser Ile Thr Pro Leu His Ala Ala Ser Leu Gln Gly Gln 
    50                  55                  60                  


Ala Arg Cys Val Gln Leu Leu Leu Ala Ala Gly Ala Gln Val Asp Ala 
65                  70                  75                  80  


Arg Asn Ile Asp Gly Ser Thr Pro Leu Cys Asp Ala Cys Ala Ser Gly 
                85                  90                  95      


Ser Ile Glu Cys Val Lys Leu Leu Leu Ser Tyr Gly Ala Lys Val Asn 
            100                 105                 110         


Pro Pro Leu Tyr Thr Ala Ser Pro Leu His Glu Ala Cys Met Ser Gly 
        115                 120                 125             


Ser Ser Glu Cys Val Arg Leu Leu Ile Asp Val Gly Ala Asn Leu Glu 
    130                 135                 140                 


Ala His Asp Cys His Phe Gly Thr Pro Leu His Val Ala Cys Ala Arg 
145                 150                 155                 160 


Glu His Leu Asp Cys Val Lys Val Leu Leu Asn Ala Gly Ala Asn Val 
                165                 170                 175     


Asn Ala Ala Lys Leu His Glu Thr Ala Leu His His Ala Ala Lys Val 
            180                 185                 190         


Lys Asn Val Asp Leu Ile Glu Met Leu Ile Glu Phe Gly Gly Asn Ile 
        195                 200                 205             


Tyr Ala Arg Asp Asn Arg Gly Lys Lys Pro Ser Asp Tyr Thr Trp Ser 
    210                 215                 220                 


Ser Ser Ala Pro Ala Lys Cys Phe Glu Tyr Tyr Glu Lys Thr Pro Leu 
225                 230                 235                 240 


Thr Leu Ser Gln Leu Cys Arg Val Asn Leu Arg Lys Ala Thr Gly Val 
                245                 250                 255     


Arg Gly Leu Glu Lys Ile Ala Lys Leu Asn Ile Pro Pro Arg Leu Ile 
            260                 265                 270         


Asp Tyr Leu Ser Tyr Asn 
        275             


<210>  827
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB15__Homo_sapiens__XP_005250203

<400>  827

Met Asp Thr Asn Asp Asp Pro Asp Glu Asp His Leu Thr Ser Tyr Asp 
1               5                   10                  15      


Ile Gln Leu Ser Ile Gln Glu Ser Ile Glu Ala Ser Lys Thr Ala Leu 
            20                  25                  30          


Cys Pro Glu Arg Phe Val Pro Leu Ser Ala Gln Asn Arg Lys Leu Val 
        35                  40                  45              


Glu Ala Ile Lys Gln Gly His Ile Pro Glu Leu Gln Glu Tyr Val Lys 
    50                  55                  60                  


Tyr Lys Tyr Ala Met Asp Glu Ala Asp Glu Lys Gly Trp Phe Pro Leu 
65                  70                  75                  80  


His Glu Ala Val Val Gln Pro Ile Gln Gln Ile Leu Glu Ile Val Leu 
                85                  90                  95      


Asp Ala Ser Tyr Lys Thr Leu Trp Glu Phe Lys Thr Cys Asp Gly Glu 
            100                 105                 110         


Thr Pro Leu Thr Leu Ala Val Lys Ala Gly Leu Val Glu Asn Val Arg 
        115                 120                 125             


Thr Leu Leu Glu Lys Gly Val Trp Pro Asn Thr Lys Asn Asp Lys Gly 
    130                 135                 140                 


Glu Thr Pro Leu Leu Ile Ala Val Lys Lys Gly Ser Tyr Asp Met Val 
145                 150                 155                 160 


Ser Thr Leu Ile Lys His Asn Thr Ser Leu Asp Gln Pro Cys Val Lys 
                165                 170                 175     


Arg Trp Ser Ala Met His Glu Ala Ala Lys Gln Gly Arg Lys Asp Ile 
            180                 185                 190         


Val Ala Leu Leu Leu Lys His Gly Gly Asn Val His Leu Arg Asp Gly 
        195                 200                 205             


Phe Gly Val Thr Pro Leu Gly Val Ala Ala Glu Tyr Gly His Cys Asp 
    210                 215                 220                 


Val Leu Glu His Leu Ile His Lys Gly Gly Asp Val Leu Ala Leu Ala 
225                 230                 235                 240 


Asp Asp Gly Ala Ser Val Leu Phe Glu Ala Ala Gly Gly Gly Asn Pro 
                245                 250                 255     


Asp Cys Ile Ser Leu Leu Leu Glu Tyr Gly Gly Ser Gly Asn Val Pro 
            260                 265                 270         


Asn Arg Ala Gly His Leu Pro Ile His Arg Ala Ala Tyr Glu Gly His 
        275                 280                 285             


Tyr Leu Ala Leu Lys Tyr Leu Ile Pro Val Thr Ser Lys Asn Ala Ile 
    290                 295                 300                 


Arg Lys Ser Gly Leu Thr Pro Ile His Ser Ala Ala Asp Gly Gln Asn 
305                 310                 315                 320 


Ala Gln Cys Leu Glu Leu Leu Ile Glu Asn Gly Phe Asp Val Asn Thr 
                325                 330                 335     


Leu Leu Ala Asp His Ile Ser Gln Ser Tyr Asp Asp Glu Arg Lys Thr 
            340                 345                 350         


Ala Leu Tyr Phe Gly Val Ser Asn Asn Asp Val His Cys Thr Glu Val 
        355                 360                 365             


Leu Leu Ala Ala Gly Ala Asp Pro Asn Leu Asp Pro Leu Asn Cys Leu 
    370                 375                 380                 


Leu Val Ala Val Arg Ala Asn Asn Tyr Glu Ile Val Arg Leu Leu Leu 
385                 390                 395                 400 


Ser His Gly Ala Asn Val Asn Cys Tyr Phe Met His Val Asn Asp Thr 
                405                 410                 415     


Arg Phe Pro Ser Val Ile Gln Tyr Ala Leu Asn Asp Glu Val Met Leu 
            420                 425                 430         


Arg Leu Leu Leu Asn Asn Gly Tyr Gln Val Glu Met Cys Phe Asp Cys 
        435                 440                 445             


Met His Gly Asp Ile Phe Gly Asn Ser Phe Val Trp Ser Glu Ile Gln 
    450                 455                 460                 


Glu Glu Val Leu Pro Gly Trp Thr Ser Cys Val Ile Lys Asp Asn Pro 
465                 470                 475                 480 


Phe Cys Glu Phe Ile Thr Val Pro Trp Met Lys His Leu Val Gly Arg 
                485                 490                 495     


Val Thr Arg Val Leu Ile Asp Tyr Met Asp Tyr Val Pro Leu Cys Ala 
            500                 505                 510         


Lys Leu Lys Ser Ala Leu Glu Val Gln Arg Glu Trp Pro Glu Ile Arg 
        515                 520                 525             


Gln Ile Leu Glu Asn Pro Cys Ser Leu Lys His Leu Cys Arg Leu Lys 
    530                 535                 540                 


Ile Arg Arg Leu Met Gly Leu Gln Lys Leu Cys Gln Pro Ala Ser Val 
545                 550                 555                 560 


Glu Lys Leu Pro Leu Pro Pro Ala Ile Gln Arg Tyr Ile Leu Phe Lys 
                565                 570                 575     


Glu Tyr Asp Leu Tyr Gly Gln Glu Leu Lys Leu Thr 
            580                 585             


<210>  828
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB18__Homo_sapiens__NP_997721

<400>  828

Met Ser Asn Ser Asp Tyr Leu Pro Asp Tyr Pro Leu Asn Ser Asp Leu 
1               5                   10                  15      


Val Lys Arg Leu Lys Ser Ala Leu Asp Ala Lys Asp Glu Glu Arg Val 
            20                  25                  30          


Arg Asp Leu Ile Cys Thr Glu Ile Thr Pro Val Asp Ala Val Ile Glu 
        35                  40                  45              


Leu Ala Asn Asp Asp Trp Met Lys Asp Pro Ser Ala Gln Leu Pro Thr 
    50                  55                  60                  


Gly Met Leu Leu Gly Asp Leu Asp His Leu Lys Pro Leu Met Asp Gln 
65                  70                  75                  80  


Phe Phe Gln Asp Ala Asn Val Val Phe Glu Ile Asn Lys Asp Glu Met 
                85                  90                  95      


Glu Trp Gln Val Lys Ser Pro Ala Thr Phe Gly Leu Ser Gly Leu Trp 
            100                 105                 110         


Thr Leu Glu Tyr Lys Arg Glu Leu Thr Thr Pro Leu Cys Ile Ala Ala 
        115                 120                 125             


Ala His Gly His Thr Ala Cys Val Arg His Leu Leu Gly Arg Gly Ala 
    130                 135                 140                 


Asp Pro Asp Ala Ser Pro Gly Gly Arg Gly Ala Leu His Glu Ala Cys 
145                 150                 155                 160 


Leu Gly Gly His Thr Ala Cys Val Arg Leu Leu Leu Gln His Arg Ala 
                165                 170                 175     


Asp Pro Asp Leu Leu Ser Ala Glu Gly Leu Ala Pro Leu His Leu Cys 
            180                 185                 190         


Arg Thr Ala Ala Ser Leu Gly Cys Ala Gln Ala Leu Leu Glu His Gly 
        195                 200                 205             


Ala Ser Val Gln Arg Val Gly Gly Thr Gly Arg Asp Thr Pro Leu His 
    210                 215                 220                 


Val Ala Ala Gln Arg Gly Leu Asp Glu His Ala Arg Leu Tyr Leu Gly 
225                 230                 235                 240 


Arg Gly Ala His Val Asp Ala Arg Asn Gly Arg Gly Glu Thr Ala Leu 
                245                 250                 255     


Ser Ala Ala Cys Gly Ala Ala Arg Arg Pro Asp Glu His Gly Arg Cys 
            260                 265                 270         


Leu Arg Leu Cys Ala Leu Leu Leu Arg Arg Gly Ala Glu Ala Asp Ala 
        275                 280                 285             


Arg Asp Glu Asp Glu Arg Ser Pro Leu His Lys Ala Cys Gly His Ala 
    290                 295                 300                 


Ser His Ser Leu Ala Arg Leu Leu Leu Arg His Gly Ala Asp Ala Gly 
305                 310                 315                 320 


Ala Leu Asp Tyr Gly Gly Ala Ser Pro Leu Gly Arg Val Leu Gln Thr 
                325                 330                 335     


Ala Ser Cys Ala Leu Gln Ala Ser Pro Gln Arg Thr Val Gln Ala Leu 
            340                 345                 350         


Leu Asn His Gly Ser Pro Thr Val Trp Pro Asp Ala Phe Pro Lys Val 
        355                 360                 365             


Leu Lys Thr Cys Ala Ser Val Pro Ala Val Ile Glu Val Leu Phe Asn 
    370                 375                 380                 


Ser Tyr Pro Gln Leu Cys Leu Ser Glu Ser Trp Lys Glu Val Ile Pro 
385                 390                 395                 400 


Glu Glu Val Phe Gln Met His Lys Pro Phe Tyr Gln Ser Leu Phe Ala 
                405                 410                 415     


Leu Ala Leu Thr Pro Arg Cys Leu Gln His Leu Cys Arg Cys Ala Leu 
            420                 425                 430         


Arg Arg Leu Phe Gly Lys Arg Cys Phe Asp Leu Ile Pro Leu Leu Pro 
        435                 440                 445             


Leu Pro Lys Pro Leu Gln Asn Tyr Leu Leu Leu Glu Pro Gln Gly Val 
    450                 455                 460                 


Leu His 
465     


<210>  829
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB1__Homo_sapiens__NP_001035535

<400>  829

Met Ala Glu Gly Gly Ser Pro Asp Gly Arg Ala Gly Pro Gly Ser Ala 
1               5                   10                  15      


Gly Arg Asn Leu Lys Glu Trp Leu Arg Glu Gln Phe Cys Asp His Pro 
            20                  25                  30          


Leu Glu His Cys Glu Asp Thr Arg Leu His Asp Ala Ala Tyr Val Gly 
        35                  40                  45              


Asp Leu Gln Thr Leu Arg Ser Leu Leu Gln Glu Glu Ser Tyr Arg Ser 
    50                  55                  60                  


Arg Ile Asn Glu Lys Ser Val Trp Cys Cys Gly Trp Leu Pro Cys Thr 
65                  70                  75                  80  


Pro Leu Arg Ile Ala Ala Thr Ala Gly His Gly Ser Cys Val Asp Phe 
                85                  90                  95      


Leu Ile Arg Lys Gly Ala Glu Val Asp Leu Val Asp Val Lys Gly Gln 
            100                 105                 110         


Thr Ala Leu Tyr Val Ala Val Val Asn Gly His Leu Glu Ser Thr Gln 
        115                 120                 125             


Ile Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Ser Arg His His Arg 
    130                 135                 140                 


Ser Thr Pro Val Tyr His Ala Ser Arg Val Gly Arg Ala Asp Ile Leu 
145                 150                 155                 160 


Lys Ala Leu Ile Arg Tyr Gly Ala Asp Val Asp Val Asn His His Leu 
                165                 170                 175     


Thr Pro Asp Val Gln Pro Arg Phe Ser Arg Arg Leu Thr Ser Leu Val 
            180                 185                 190         


Val Cys Pro Leu Tyr Ile Ser Ala Ala Tyr His Asn Leu Gln Cys Phe 
        195                 200                 205             


Arg Leu Leu Leu Leu Ala Gly Ala Asn Pro Asp Phe Asn Cys Asn Gly 
    210                 215                 220                 


Pro Val Asn Thr Gln Gly Phe Tyr Arg Gly Ser Pro Gly Cys Val Met 
225                 230                 235                 240 


Asp Ala Val Leu Arg His Gly Cys Glu Ala Ala Phe Val Ser Leu Leu 
                245                 250                 255     


Val Glu Phe Gly Ala Asn Leu Asn Leu Val Lys Trp Glu Ser Leu Gly 
            260                 265                 270         


Pro Glu Ser Arg Gly Arg Arg Lys Val Asp Pro Glu Ala Leu Gln Val 
        275                 280                 285             


Phe Lys Glu Ala Arg Ser Val Pro Arg Thr Leu Leu Cys Leu Cys Arg 
    290                 295                 300                 


Val Ala Val Arg Arg Ala Leu Gly Lys His Arg Leu His Leu Ile Pro 
305                 310                 315                 320 


Ser Leu Pro Leu Pro Asp Pro Ile Lys Lys Phe Leu Leu His Glu 
                325                 330                 335 


<210>  830
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB2__Homo_sapiens__NP_057234

<400>  830

Met Thr Arg Phe Ser Tyr Ala Glu Tyr Phe Ser Leu Phe His Ser Cys 
1               5                   10                  15      


Ser Ala Pro Ser Arg Ser Thr Ala Pro Pro Glu Ser Ser Pro Ala Arg 
            20                  25                  30          


Ala Pro Met Gly Leu Phe Gln Gly Val Met Gln Lys Tyr Ser Ser Ser 
        35                  40                  45              


Leu Phe Lys Thr Ser Gln Leu Ala Pro Ala Asp Pro Leu Ile Lys Ala 
    50                  55                  60                  


Ile Lys Asp Gly Asp Glu Glu Ala Leu Lys Thr Met Ile Lys Glu Gly 
65                  70                  75                  80  


Lys Asn Leu Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu 
                85                  90                  95      


Ala Ala Tyr Tyr Gly Gln Val Gly Cys Leu Lys Val Leu Gln Arg Ala 
            100                 105                 110         


Tyr Pro Gly Thr Ile Asp Gln Arg Thr Leu Gln Glu Glu Thr Ala Val 
        115                 120                 125             


Tyr Leu Ala Thr Cys Arg Gly His Leu Asp Cys Leu Leu Ser Leu Leu 
    130                 135                 140                 


Gln Ala Gly Ala Glu Pro Asp Ile Ser Asn Lys Ser Arg Glu Thr Pro 
145                 150                 155                 160 


Leu Tyr Lys Ala Cys Glu Arg Lys Asn Ala Glu Ala Val Lys Ile Leu 
                165                 170                 175     


Val Gln His Asn Ala Asp Thr Asn His Arg Cys Asn Arg Gly Trp Thr 
            180                 185                 190         


Ala Leu His Glu Ser Val Ser Arg Asn Asp Leu Glu Val Met Gln Ile 
        195                 200                 205             


Leu Val Ser Gly Gly Ala Lys Val Glu Ser Lys Asn Ala Tyr Gly Ile 
    210                 215                 220                 


Thr Pro Leu Phe Val Ala Ala Gln Ser Gly Gln Leu Glu Ala Leu Arg 
225                 230                 235                 240 


Phe Leu Ala Lys Tyr Gly Ala Asp Ile Asn Thr Gln Ala Ser Asp Asn 
                245                 250                 255     


Ala Ser Ala Leu Tyr Glu Ala Cys Lys Asn Glu His Glu Glu Val Val 
            260                 265                 270         


Glu Phe Leu Leu Ser Gln Gly Ala Asp Ala Asn Lys Thr Asn Lys Asp 
        275                 280                 285             


Gly Leu Leu Pro Leu His Ile Ala Ser Lys Lys Gly Asn Tyr Arg Ile 
    290                 295                 300                 


Val Gln Met Leu Leu Pro Val Thr Ser Arg Thr Arg Ile Arg Arg Ser 
305                 310                 315                 320 


Gly Val Ser Pro Leu His Leu Ala Ala Glu Arg Asn His Asp Glu Val 
                325                 330                 335     


Leu Glu Ala Leu Leu Ser Ala Arg Phe Asp Val Asn Thr Pro Leu Ala 
            340                 345                 350         


Pro Glu Arg Ala Arg Leu Tyr Glu Asp Arg Arg Ser Ser Ala Leu Tyr 
        355                 360                 365             


Phe Ala Val Val Asn Asn Asn Val Tyr Ala Thr Glu Leu Leu Leu Gln 
    370                 375                 380                 


His Gly Ala Asp Pro Asn Arg Asp Val Ile Ser Pro Leu Leu Val Ala 
385                 390                 395                 400 


Ile Arg His Gly Cys Leu Arg Thr Met Gln Leu Leu Leu Asp His Gly 
                405                 410                 415     


Ala Asn Ile Asp Ala Tyr Ile Ala Thr His Pro Thr Ala Phe Pro Ala 
            420                 425                 430         


Thr Ile Met Phe Ala Met Lys Cys Leu Ser Leu Leu Lys Phe Leu Met 
        435                 440                 445             


Asp Leu Gly Cys Asp Gly Glu Pro Cys Phe Ser Cys Leu Tyr Gly Asn 
    450                 455                 460                 


Gly Pro His Pro Pro Ala Pro Gln Pro Ser Ser Arg Phe Asn Asp Ala 
465                 470                 475                 480 


Pro Ala Ala Asp Lys Glu Pro Ser Val Val Gln Phe Cys Glu Phe Val 
                485                 490                 495     


Ser Ala Pro Glu Val Ser Arg Trp Ala Gly Pro Ile Ile Asp Val Leu 
            500                 505                 510         


Leu Asp Tyr Val Gly Asn Val Gln Leu Cys Ser Arg Leu Lys Glu His 
        515                 520                 525             


Ile Asp Ser Phe Glu Asp Trp Ala Val Ile Lys Glu Lys Ala Glu Pro 
    530                 535                 540                 


Pro Arg Pro Leu Ala His Leu Cys Arg Leu Arg Val Arg Lys Ala Ile 
545                 550                 555                 560 


Gly Lys Tyr Arg Ile Lys Leu Leu Asp Thr Leu Pro Leu Pro Gly Arg 
                565                 570                 575     


Leu Ile Arg Tyr Leu Lys Tyr Glu Asn Thr Gln 
            580                 585         


<210>  831
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB6__Homo_sapiens__NP_060343

<400>  831

Met Pro Phe Leu His Gly Phe Arg Arg Ile Ile Phe Glu Tyr Gln Pro 
1               5                   10                  15      


Leu Val Asp Ala Ile Leu Gly Ser Leu Gly Ile Gln Asp Pro Glu Arg 
            20                  25                  30          


Gln Glu Ser Leu Asp Arg Pro Ser Tyr Val Ala Ser Glu Glu Ser Arg 
        35                  40                  45              


Ile Leu Val Leu Thr Glu Leu Leu Glu Arg Lys Ala His Ser Pro Phe 
    50                  55                  60                  


Tyr Gln Glu Gly Val Ser Asn Ala Leu Leu Lys Met Ala Glu Leu Gly 
65                  70                  75                  80  


Leu Thr Arg Ala Ala Asp Val Leu Leu Arg His Gly Ala Asn Leu Asn 
                85                  90                  95      


Phe Glu Asp Pro Val Thr Tyr Tyr Thr Ala Leu His Ile Ala Val Leu 
            100                 105                 110         


Arg Asn Gln Pro Asp Met Val Glu Leu Leu Val His His Gly Ala Asp 
        115                 120                 125             


Val Asn Arg Arg Asp Arg Ile His Glu Ser Ser Pro Leu Asp Leu Ala 
    130                 135                 140                 


Ser Glu Glu Pro Glu Arg Leu Pro Cys Leu Gln Arg Leu Leu Asp Leu 
145                 150                 155                 160 


Gly Ala Asp Val Asn Ala Ala Asp Lys His Gly Lys Thr Ala Leu Leu 
                165                 170                 175     


His Ala Leu Ala Ser Ser Asp Gly Val Gln Ile His Asn Thr Glu Asn 
            180                 185                 190         


Ile Arg Leu Leu Leu Glu Gly Gly Ala Asp Val Lys Ala Thr Thr Lys 
        195                 200                 205             


Asp Gly Asp Thr Val Phe Thr Cys Ile Ile Phe Leu Leu Gly Glu Thr 
    210                 215                 220                 


Val Gly Gly Asp Lys Glu Glu Ala Gln Met Ile Asn Arg Phe Cys Phe 
225                 230                 235                 240 


Gln Val Thr Arg Leu Leu Leu Ala His Gly Ala Asp Pro Ser Glu Cys 
                245                 250                 255     


Pro Ala His Glu Ser Leu Thr His Ile Cys Leu Lys Ser Phe Lys Leu 
            260                 265                 270         


His Phe Pro Leu Leu Arg Phe Leu Leu Glu Ser Gly Ala Ala Tyr Asn 
        275                 280                 285             


Cys Ser Leu His Gly Ala Ser Cys Trp Ser Gly Phe His Ile Ile Phe 
    290                 295                 300                 


Glu Arg Leu Cys Ser His Pro Gly Cys Thr Glu Asp Glu Ser His Ala 
305                 310                 315                 320 


Asp Leu Leu Arg Lys Ala Glu Thr Val Leu Asp Leu Met Val Thr Asn 
                325                 330                 335     


Ser Gln Lys Leu Gln Leu Pro Glu Asn Phe Asp Ile His Pro Val Gly 
            340                 345                 350         


Ser Leu Ala Glu Lys Ile Gln Ala Leu His Phe Ser Leu Arg Gln Leu 
        355                 360                 365             


Glu Ser Tyr Pro Pro Pro Leu Lys His Leu Cys Arg Val Ala Ile Arg 
    370                 375                 380                 


Leu Tyr Leu Gln Pro Trp Pro Val Asp Val Lys Val Lys Ala Leu Pro 
385                 390                 395                 400 


Leu Pro Asp Arg Leu Lys Trp Tyr Leu Leu Ser Glu His Ser Gly Ser 
                405                 410                 415     


Val Glu Asp Asp Ile 
            420     


<210>  832
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASB7__Homo_sapiens__NP_078984

<400>  832

Met Leu His His His Cys Arg Arg Asn Pro Glu Leu Gln Glu Glu Leu 
1               5                   10                  15      


Gln Ile Gln Ala Ala Val Ala Ala Gly Asp Val His Thr Val Arg Lys 
            20                  25                  30          


Met Leu Glu Gln Gly Tyr Ser Pro Asn Gly Arg Asp Ala Asn Gly Trp 
        35                  40                  45              


Thr Leu Leu His Phe Ser Ala Ala Arg Gly Lys Glu Arg Cys Val Arg 
    50                  55                  60                  


Val Phe Leu Glu His Gly Ala Asp Pro Thr Val Lys Asp Leu Ile Gly 
65                  70                  75                  80  


Gly Phe Thr Ala Leu His Tyr Ala Ala Met His Gly Arg Ala Arg Ile 
                85                  90                  95      


Ala Arg Leu Met Leu Glu Ser Glu Tyr Arg Ser Asp Ile Ile Asn Ala 
            100                 105                 110         


Lys Ser Asn Asp Gly Trp Thr Pro Leu His Val Ala Ala His Tyr Gly 
        115                 120                 125             


Arg Asp Ser Phe Val Arg Leu Leu Leu Glu Phe Lys Ala Glu Val Asp 
    130                 135                 140                 


Pro Leu Ser Asp Lys Gly Thr Thr Pro Leu Gln Leu Ala Ile Ile Arg 
145                 150                 155                 160 


Glu Arg Ser Ser Cys Val Lys Ile Leu Leu Asp His Asn Ala Asn Ile 
                165                 170                 175     


Asp Ile Gln Asn Gly Phe Leu Leu Arg Tyr Ala Val Ile Lys Ser Asn 
            180                 185                 190         


His Ser Tyr Cys Arg Met Phe Leu Gln Arg Gly Ala Asp Thr Asn Leu 
        195                 200                 205             


Gly Arg Leu Glu Asp Gly Gln Thr Pro Leu His Leu Ser Ala Leu Arg 
    210                 215                 220                 


Asp Asp Val Leu Cys Ala Arg Met Leu Tyr Asn Tyr Gly Ala Asp Thr 
225                 230                 235                 240 


Asn Thr Arg Asn Tyr Glu Gly Gln Thr Pro Leu Ala Val Ser Ile Ser 
                245                 250                 255     


Ile Ser Gly Ser Ser Arg Pro Cys Leu Asp Phe Leu Gln Glu Val Thr 
            260                 265                 270         


Ser Met 
        


<210>  833
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASCC1__Homo_sapiens__NP_001185727

<400>  833

Met Glu Val Leu Arg Pro Gln Leu Ile Arg Ile Asp Gly Arg Asn Tyr 
1               5                   10                  15      


Arg Lys Asn Pro Val Gln Glu Gln Thr Tyr Gln His Glu Glu Asp Glu 
            20                  25                  30          


Glu Asp Phe Tyr Gln Gly Ser Met Glu Cys Ala Asp Glu Pro Cys Asp 
        35                  40                  45              


Ala Tyr Glu Val Glu Gln Thr Pro Gln Gly Phe Arg Ser Thr Leu Arg 
    50                  55                  60                  


Ala Pro Ser Leu Leu Tyr Lys His Ile Val Gly Lys Arg Gly Asp Thr 
65                  70                  75                  80  


Arg Lys Lys Ile Glu Met Glu Thr Lys Thr Ser Ile Ser Ile Pro Lys 
                85                  90                  95      


Pro Gly Gln Asp Gly Glu Ile Val Ile Thr Gly Gln His Arg Asn Gly 
            100                 105                 110         


Val Ile Ser Ala Arg Thr Arg Ile Asp Val Leu Leu Asp Thr Phe Arg 
        115                 120                 125             


Arg Lys Gln Pro Phe Thr His Phe Leu Ala Phe Phe Leu Asn Glu Val 
    130                 135                 140                 


Glu Val Gln Glu Gly Phe Leu Arg Phe Gln Glu Glu Val Leu Ala Lys 
145                 150                 155                 160 


Cys Ser Met Asp His Gly Val Asp Ser Ser Ile Phe Gln Asn Pro Lys 
                165                 170                 175     


Lys Leu His Leu Thr Ile Gly Met Leu Val Leu Leu Ser Glu Glu Glu 
            180                 185                 190         


Ile Gln Gln Thr Cys Glu Met Leu Gln Gln Cys Lys Glu Glu Phe Ile 
        195                 200                 205             


Asn Asp Ile Ser Gly Gly Lys Pro Leu Glu Val Glu Met Ala Gly Ile 
    210                 215                 220                 


Glu Tyr Met Asn Asp Asp Pro Gly Met Val Asp Val Leu Tyr Ala Lys 
225                 230                 235                 240 


Val His Met Lys Asp Gly Ser Asn Arg Leu Gln Glu Leu Val Asp Arg 
                245                 250                 255     


Val Leu Glu Arg Phe Gln Ala Ser Gly Leu Ile Val Lys Glu Trp Asn 
            260                 265                 270         


Ser Val Lys Leu His Ala Thr Val Met Asn Thr Leu Phe Arg Lys Asp 
        275                 280                 285             


Pro Asn Ala Glu Gly Arg Tyr Asn Leu Tyr Thr Ala Glu Gly Lys Tyr 
    290                 295                 300                 


Ile Phe Lys Glu Arg Glu Ser Phe Asp Gly Arg Asn Ile Leu Lys Leu 
305                 310                 315                 320 


Phe Glu Asn Phe Tyr Phe Gly Ser Leu Lys Leu Asn Ser Ile His Ile 
                325                 330                 335     


Ser Gln Arg Phe Thr Val Asp Ser Phe Gly Asn Tyr Ala Ser Cys Gly 
            340                 345                 350         


Gln Ile Asp Phe Ser 
        355         


<210>  834
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASCC2__Homo_sapiens__NP_001229835

<400>  834

Met Pro Ala Leu Pro Leu Asp Gln Leu Gln Ile Thr His Lys Asp Pro 
1               5                   10                  15      


Lys Thr Gly Lys Leu Arg Thr Ser Pro Ala Leu Val Ile Phe Asp Glu 
            20                  25                  30          


Thr Leu Gln Lys Cys Leu Asp Ser Tyr Leu Arg Tyr Val Pro Arg Lys 
        35                  40                  45              


Phe Asp Glu Gly Val Ala Ser Ala Pro Glu Val Val Asp Met Gln Lys 
    50                  55                  60                  


Arg Leu His Arg Ser Val Phe Leu Thr Phe Leu Arg Met Ser Thr His 
65                  70                  75                  80  


Lys Glu Ser Lys Ile Leu Asp Leu Cys Val Leu Phe Gly Lys Gly Asn 
                85                  90                  95      


Ser Pro Leu Leu Gln Lys Met Ile Gly Asn Ile Phe Thr Gln Gln Pro 
            100                 105                 110         


Ser Tyr Tyr Ser Asp Leu Asp Glu Thr Leu Pro Thr Ile Leu Gln Val 
        115                 120                 125             


Phe Ser Asn Ile Leu Gln His Cys Gly Leu Gln Gly Asp Gly Ala Asn 
    130                 135                 140                 


Thr Thr Pro Gln Lys Leu Glu Glu Arg Gly Arg Leu Thr Pro Ser Asp 
145                 150                 155                 160 


Met Pro Leu Leu Glu Leu Lys Asp Ile Val Leu Tyr Leu Cys Asp Thr 
                165                 170                 175     


Cys Thr Thr Leu Trp Ala Phe Leu Asp Ile Phe Pro Leu Ala Cys Gln 
            180                 185                 190         


Thr Phe Gln Lys His Asp Phe Cys Tyr Arg Leu Ala Ser Phe Tyr Glu 
        195                 200                 205             


Ala Ala Ile Pro Glu Met Glu Ser Ala Ile Lys Lys Arg Arg Leu Glu 
    210                 215                 220                 


Asp Ser Lys Leu Leu Gly Asp Leu Trp Gln Arg Leu Ser His Ser Arg 
225                 230                 235                 240 


Lys Lys Leu Met Glu Ile Phe His Ile Ile Leu Asn Gln Ile Cys Leu 
                245                 250                 255     


Leu Pro Ile Leu Glu Ser Ser Cys Asp Asn Ile Gln Gly Phe Ile Glu 
            260                 265                 270         


Glu Phe Leu Gln Ile Phe Ser Ser Leu Leu Gln Glu Lys Arg Phe Leu 
        275                 280                 285             


Arg Asp Tyr Asp Ala Leu Phe Pro Val Ala Glu Asp Ile Ser Leu Leu 
    290                 295                 300                 


Gln Gln Ala Ser Ser Val Leu Asp Glu Thr Arg Thr Ala Tyr Ile Leu 
305                 310                 315                 320 


Gln Ala Val Glu Ser Ala Trp Glu Gly Val Asp Arg Arg Lys Ala Thr 
                325                 330                 335     


Asp Ala Lys Asp Pro Ser Val Ile Glu Glu Pro Asn Gly Glu Pro Asn 
            340                 345                 350         


Gly Val Thr Val Thr Ala Glu Ala Val Ser Gln Ala Ser Ser His Pro 
        355                 360                 365             


Glu Asn Ser Glu Glu Glu Glu Cys Met Gly Ala Ala Ala Ala Val Gly 
    370                 375                 380                 


Pro Ala Met Cys Gly Val Glu Leu Asp Ser Leu Ile Ser Gln Val Lys 
385                 390                 395                 400 


Asp Leu Leu Pro Asp Leu Gly Glu Gly Phe Ile Leu Ala Cys Leu Glu 
                405                 410                 415     


Tyr Tyr His Tyr Asp Pro Glu Gln Val Ile Asn Asn Ile Leu Glu Glu 
            420                 425                 430         


Arg Leu Ala Pro Thr Leu Ser Gln Leu Asp Arg Asn Leu Asp Arg Glu 
        435                 440                 445             


Met Lys Pro Asp Pro Thr Pro Leu Leu Thr Ser Arg His Asn Val Phe 
    450                 455                 460                 


Gln Asn Asp Glu Phe Asp Val Phe Ser Arg Asp Ser Val Asp Leu Ser 
465                 470                 475                 480 


Arg Val His Lys Gly Lys Ser Thr Arg Lys Glu Glu Asn Thr Arg Ser 
                485                 490                 495     


Leu Leu Asn Asp Lys Arg Ala Val Ala Ala Gln Arg Gln Arg Tyr Glu 
            500                 505                 510         


Gln Tyr Ser Val Val Val Glu Glu Val Pro Leu Gln Pro Gly Glu Ser 
        515                 520                 525             


Leu Pro Tyr His Ser Val Tyr Tyr Glu Asp Glu Tyr Asp Asp Thr Tyr 
    530                 535                 540                 


Asp Gly Asn Gln Val Gly Ala Asn Asp Ala Asp Ser Asp Asp Glu Leu 
545                 550                 555                 560 


Ile Ser Arg Arg Pro Phe Thr Ile Pro Gln Val Leu Arg Thr Lys Val 
                565                 570                 575     


Pro Arg Glu Gly Gln Glu Glu Asp Asp Asp Asp Glu Glu Asp Asp Ala 
            580                 585                 590         


Asp Glu Glu Ala Pro Lys Pro Asp His Phe Val Gln Asp Pro Ala Val 
        595                 600                 605             


Leu Arg Glu Lys Ala Glu Ala Arg Arg Met Ala Phe Leu Ala Lys Lys 
    610                 615                 620                 


Gly Tyr Arg His Asp Ser Ser Thr Ala Val Ala Gly Ser Pro Arg Gly 
625                 630                 635                 640 


His Gly Gln Ser Arg Glu Thr Thr Gln Glu Arg Arg Lys Lys Glu Ala 
                645                 650                 655     


Asn Lys Ala Thr Arg Ala Asn His Asn Arg Arg Thr Met Ala Asp Arg 
            660                 665                 670         


Lys Arg Ser Lys Gly Met Ile Pro Ser 
        675                 680     


<210>  835
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASCC3__Homo_sapiens__NP_001271200

<400>  835

Met Ala Leu Pro Arg Leu Thr Gly Ala Leu Arg Ser Phe Ser Asn Val 
1               5                   10                  15      


Thr Lys Gln Asp Asn Tyr Asn Glu Glu Val Ala Asp Leu Lys Ile Lys 
            20                  25                  30          


Arg Ser Lys Leu His Glu Gln Val Leu Asp Leu Gly Leu Thr Trp Lys 
        35                  40                  45              


Lys Ile Ile Lys Phe Leu Asn Glu Lys Leu Glu Lys Ser Lys Met Gln 
    50                  55                  60                  


Ser Ile Asn Glu Asp Leu Lys Asp Ile Leu His Ala Ala Lys Gln Ile 
65                  70                  75                  80  


Val Gly Thr Asp Asn Gly Arg Glu Ala Ile Glu Ser Gly Ala Ala Phe 
                85                  90                  95      


Leu Phe Met Thr Phe His Leu Lys Asp Ser Val Gly His Lys Glu Thr 
            100                 105                 110         


Lys Ala Ile Lys Gln Met Phe Gly Pro Phe Pro Ser Ser Ser Ala Thr 
        115                 120                 125             


Ala Ala Cys Asn Ala Thr Asn Arg Ile Ile Ser His Phe Ser Gln Asp 
    130                 135                 140                 


Asp Leu Thr Ala Leu Val Gln Met Thr Glu Lys Glu His Gly Asp Arg 
145                 150                 155                 160 


Val Phe Phe Gly Lys Asn Leu Ala Phe Ser Phe Asp Met His Asp Leu 
                165                 170                 175     


Asp His Phe Asp Glu Leu Pro Ile Asn Gly Glu Thr Gln Lys Thr Ile 
            180                 185                 190         


Ser Leu Asp Tyr Lys Lys Phe Leu Asn Glu His Leu Gln Glu Ala Cys 
        195                 200                 205             


Thr Pro Glu Leu Lys Pro Val Glu Lys Thr Asn Gly Ser Phe Leu Trp 
    210                 215                 220                 


Cys Glu Val Glu Lys Tyr Leu Asn Ser Thr Leu Lys Glu Met Thr Glu 
225                 230                 235                 240 


Val Pro Arg Val Glu Asp Leu Cys Cys Thr Leu Tyr Asp Met Leu Ala 
                245                 250                 255     


Ser Ile Lys Ser Gly Asp Glu Leu Gln Asp Glu Leu Phe Glu Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile 
        275                 280                 285             


Thr Ile Val Asp Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln 
    290                 295                 300                 


Ala Leu Gln Asp Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro 
305                 310                 315                 320 


Asn Tyr Gly Cys Gln Val Thr Ile Gln Ser Glu Gln Glu Lys Gln Leu 
                325                 330                 335     


Met Lys Gln Tyr Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys 
            340                 345                 350         


Lys Ala Gly Glu Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp 
        355                 360                 365             


Pro Lys Glu Leu Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg 
    370                 375                 380                 


Ser Val Pro Ile Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile 
385                 390                 395                 400 


His Tyr Pro His Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Thr Ser 
                405                 410                 415     


Ala Phe Ile Ala Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg 
            420                 425                 430         


Glu Asn Asn Lys Leu Tyr Glu Glu Val Arg Ile Pro Tyr Ser Glu Pro 
        435                 440                 445             


Met Pro Leu Ser Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp 
    450                 455                 460                 


Glu Ile Gly Gln Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile 
465                 470                 475                 480 


Gln Ser Ile Val Phe Glu Thr Ala Tyr Asn Thr Asn Glu Asn Met Leu 
                485                 490                 495     


Ile Cys Ala Pro Thr Gly Ala Gly Lys Thr Asn Ile Ala Met Leu Thr 
            500                 505                 510         


Val Leu His Glu Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys 
        515                 520                 525             


Asn Glu Phe Lys Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala 
    530                 535                 540                 


Glu Met Thr Asp Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile 
545                 550                 555                 560 


Val Lys Glu Leu Thr Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu 
                565                 570                 575     


Arg Thr Gln Met Leu Val Thr Thr Pro Glu Lys Trp Asp Val Val Thr 
            580                 585                 590         


Arg Lys Ser Val Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu 
        595                 600                 605             


Ile Leu Asp Glu Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu 
    610                 615                 620                 


Glu Ser Ile Val Ala Arg Thr Leu Arg Gln Val Glu Ser Thr Gln Ser 
625                 630                 635                 640 


Met Ile Arg Ile Leu Gly Leu Ser Ala Thr Leu Pro Asn Tyr Leu Asp 
                645                 650                 655     


Val Ala Thr Phe Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe 
            660                 665                 670         


Asp Gly Arg Phe Arg Pro Val Pro Leu Gly Gln Thr Phe Leu Gly Ile 
        675                 680                 685             


Lys Cys Ala Asn Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys 
    690                 695                 700                 


Tyr Glu Asn Val Leu Lys Gln Val Lys Ala Gly His Gln Val His Leu 
705                 710                 715                 720 


Phe Tyr Leu Leu Leu His Leu Phe Ile Cys Phe 
                725                 730     


<210>  836
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASCL1__Homo_sapiens__NP_004307

<400>  836

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  837
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASCL2__Homo_sapiens__NP_005161

<400>  837

Met Asp Gly Gly Thr Leu Pro Arg Ser Ala Pro Pro Ala Pro Pro Val 
1               5                   10                  15      


Pro Val Gly Cys Ala Ala Arg Arg Arg Pro Ala Ser Pro Glu Leu Leu 
            20                  25                  30          


Arg Cys Ser Arg Arg Arg Arg Pro Ala Thr Ala Glu Thr Gly Gly Gly 
        35                  40                  45              


Ala Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys 
    50                  55                  60                  


Leu Val Asn Leu Gly Phe Gln Ala Leu Arg Gln His Val Pro His Gly 
65                  70                  75                  80  


Gly Ala Ser Lys Lys Leu Ser Lys Val Glu Thr Leu Arg Ser Ala Val 
                85                  90                  95      


Glu Tyr Ile Arg Ala Leu Gln Arg Leu Leu Ala Glu His Asp Ala Val 
            100                 105                 110         


Arg Asn Ala Leu Ala Gly Gly Leu Arg Pro Gln Ala Val Arg Pro Ser 
        115                 120                 125             


Ala Pro Arg Gly Pro Pro Gly Thr Thr Pro Val Ala Ala Ser Pro Ser 
    130                 135                 140                 


Arg Ala Ser Ser Ser Pro Gly Arg Gly Gly Ser Ser Glu Pro Gly Ser 
145                 150                 155                 160 


Pro Arg Ser Ala Tyr Ser Ser Asp Asp Ser Gly Cys Glu Gly Ala Leu 
                165                 170                 175     


Ser Pro Ala Glu Arg Glu Leu Leu Asp Phe Ser Ser Trp Leu Gly Gly 
            180                 185                 190         


Tyr 
    


<210>  838
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASCL4__Homo_sapiens__NP_982260

<400>  838

Met Met Glu Thr Arg Lys Pro Ala Glu Arg Leu Ala Leu Pro Tyr Ser 
1               5                   10                  15      


Leu Arg Thr Ala Pro Leu Gly Val Pro Gly Thr Leu Pro Gly Leu Pro 
            20                  25                  30          


Arg Arg Asp Pro Leu Arg Val Ala Leu Arg Leu Asp Ala Ala Cys Trp 
        35                  40                  45              


Glu Trp Ala Arg Ser Gly Cys Ala Arg Gly Trp Gln Tyr Leu Pro Val 
    50                  55                  60                  


Pro Leu Asp Ser Ala Phe Glu Pro Ala Phe Leu Arg Lys Arg Asn Glu 
65                  70                  75                  80  


Arg Glu Arg Gln Arg Val Arg Cys Val Asn Glu Gly Tyr Ala Arg Leu 
                85                  90                  95      


Arg Asp His Leu Pro Arg Glu Leu Ala Asp Lys Arg Leu Ser Lys Val 
            100                 105                 110         


Glu Thr Leu Arg Ala Ala Ile Asp Tyr Ile Lys His Leu Gln Glu Leu 
        115                 120                 125             


Leu Glu Arg Gln Ala Trp Gly Leu Glu Gly Ala Ala Gly Ala Val Pro 
    130                 135                 140                 


Gln Arg Arg Ala Glu Cys Asn Ser Asp Gly Glu Ser Lys Ala Ser Ser 
145                 150                 155                 160 


Ala Pro Ser Pro Ser Ser Glu Pro Glu Glu Gly Gly Ser 
                165                 170             


<210>  839
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASF1A__Homo_sapiens__NP_054753

<400>  839

Met Ala Lys Val Gln Val Asn Asn Val Val Val Leu Asp Asn Pro Ser 
1               5                   10                  15      


Pro Phe Tyr Asn Pro Phe Gln Phe Glu Ile Thr Phe Glu Cys Ile Glu 
            20                  25                  30          


Asp Leu Ser Glu Asp Leu Glu Trp Lys Ile Ile Tyr Val Gly Ser Ala 
        35                  40                  45              


Glu Ser Glu Glu Tyr Asp Gln Val Leu Asp Ser Val Leu Val Gly Pro 
    50                  55                  60                  


Val Pro Ala Gly Arg His Met Phe Val Phe Gln Ala Asp Ala Pro Asn 
65                  70                  75                  80  


Pro Gly Leu Ile Pro Asp Ala Asp Ala Val Gly Val Thr Val Val Leu 
                85                  90                  95      


Ile Thr Cys Thr Tyr Arg Gly Gln Glu Phe Ile Arg Val Gly Tyr Tyr 
            100                 105                 110         


Val Asn Asn Glu Tyr Thr Glu Thr Glu Leu Arg Glu Asn Pro Pro Val 
        115                 120                 125             


Lys Pro Asp Phe Ser Lys Leu Gln Arg Asn Ile Leu Ala Ser Asn Pro 
    130                 135                 140                 


Arg Val Thr Arg Phe His Ile Asn Trp Glu Asp Asn Thr Glu Lys Leu 
145                 150                 155                 160 


Glu Asp Ala Glu Ser Ser Asn Pro Asn Leu Gln Ser Leu Leu Ser Thr 
                165                 170                 175     


Asp Ala Leu Pro Ser Ala Ser Lys Gly Trp Ser Thr Ser Glu Asn Ser 
            180                 185                 190         


Leu Asn Val Met Leu Glu Ser His Met Asp Cys Met 
        195                 200                 


<210>  840
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASF1B__Homo_sapiens__NP_060624

<400>  840

Met Ala Lys Val Ser Val Leu Asn Val Ala Val Leu Glu Asn Pro Ser 
1               5                   10                  15      


Pro Phe His Ser Pro Phe Arg Phe Glu Ile Ser Phe Glu Cys Ser Glu 
            20                  25                  30          


Ala Leu Ala Asp Asp Leu Glu Trp Lys Ile Ile Tyr Val Gly Ser Ala 
        35                  40                  45              


Glu Ser Glu Glu Phe Asp Gln Ile Leu Asp Ser Val Leu Val Gly Pro 
    50                  55                  60                  


Val Pro Ala Gly Arg His Met Phe Val Phe Gln Ala Asp Ala Pro Asn 
65                  70                  75                  80  


Pro Ser Leu Ile Pro Glu Thr Asp Ala Val Gly Val Thr Val Val Leu 
                85                  90                  95      


Ile Thr Cys Thr Tyr His Gly Gln Glu Phe Ile Arg Val Gly Tyr Tyr 
            100                 105                 110         


Val Asn Asn Glu Tyr Leu Asn Pro Glu Leu Arg Glu Asn Pro Pro Met 
        115                 120                 125             


Lys Pro Asp Phe Ser Gln Leu Gln Arg Asn Ile Leu Ala Ser Asn Pro 
    130                 135                 140                 


Arg Val Thr Arg Phe His Ile Asn Trp Asp Asn Asn Met Asp Arg Leu 
145                 150                 155                 160 


Glu Ala Ile Glu Thr Gln Asp Pro Ser Leu Gly Cys Gly Leu Pro Leu 
                165                 170                 175     


Asn Cys Thr Pro Ile Lys Gly Leu Gly Leu Pro Gly Cys Ile Pro Gly 
            180                 185                 190         


Leu Leu Pro Glu Asn Ser Met Asp Cys Ile 
        195                 200         


<210>  841
<211>  2964
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASH1L__Homo_sapiens__XP_006711513

<400>  841

Met Asp Pro Arg Asn Thr Ala Met Leu Gly Leu Gly Ser Asp Ser Glu 
1               5                   10                  15      


Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Thr Gly Thr Leu Val 
            20                  25                  30          


Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Thr Lys Glu Glu Glu Asp 
        35                  40                  45              


Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Ala Gly Lys Asp Asp 
    50                  55                  60                  


Gly Leu Thr Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Thr Asn Phe 
65                  70                  75                  80  


Ser Glu Gly Asn Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Thr 
                85                  90                  95      


Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile 
            100                 105                 110         


Lys Thr Thr Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met 
        115                 120                 125             


Thr Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Asp Pro Ser Lys 
    130                 135                 140                 


Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu Cys Gln Ser Glu 
145                 150                 155                 160 


Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn Pro Leu Ser Lys 
                165                 170                 175     


Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr Ile Asn Ala Thr 
            180                 185                 190         


Pro Ser Thr Leu Leu Gly Ser Arg Asp Pro Asp Leu Lys Asp Arg Ala 
        195                 200                 205             


Leu Leu Asn Gly Gly Thr Ser Val Thr Glu Lys Leu Ala Gln Leu Ile 
    210                 215                 220                 


Ala Thr Cys Pro Pro Ser Lys Ser Ser Lys Thr Lys Pro Lys Lys Leu 
225                 230                 235                 240 


Gly Thr Gly Thr Thr Ala Gly Leu Val Ser Lys Asp Leu Ile Arg Lys 
                245                 250                 255     


Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys Asp Leu Ile Lys 
            260                 265                 270         


Lys Pro Thr Ile Ser Thr Ala Val Gly Leu Val Thr Lys Asp Pro Gly 
        275                 280                 285             


Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val Asn Lys Asp Ser 
    290                 295                 300                 


Val Lys Lys Leu Gly Thr Gly Thr Thr Ala Val Phe Ile Asn Lys Asn 
305                 310                 315                 320 


Leu Gly Lys Lys Pro Gly Thr Ile Thr Thr Val Gly Leu Leu Ser Lys 
                325                 330                 335     


Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro Gly Leu Val His 
            340                 345                 350         


Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Thr Val Val Gly Leu Val 
        355                 360                 365             


Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Thr Val Gly Leu Val Ala 
    370                 375                 380                 


Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala Met Gly Leu Val 
385                 390                 395                 400 


Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro Leu Ala Gly Leu 
                405                 410                 415     


Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala Leu Leu Pro Thr 
            420                 425                 430         


Gln Glu Pro Leu Lys Ala Ser Cys Ser Thr Asn Ile Asn Asn Gln Glu 
        435                 440                 445             


Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala Thr Ser Lys Thr 
    450                 455                 460                 


Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser Ile Leu Glu Lys 
465                 470                 475                 480 


Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys Glu Met Phe Asn 
                485                 490                 495     


Glu Gly Thr Cys Ile Gln Gln Asp Ser Phe Ser Ser Ser Glu Lys Gly 
            500                 505                 510         


Ser Tyr Glu Thr Ser Lys His Glu Lys Gln Pro Pro Val Tyr Cys Thr 
        515                 520                 525             


Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val Ser Thr Ala Lys 
    530                 535                 540                 


Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro Ser Pro Ser Pro 
545                 550                 555                 560 


Thr Val Ser Val Asn Pro Leu Thr Arg Ser Pro Pro Glu Thr Ser Ser 
                565                 570                 575     


Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Thr Thr Glu Leu Ile 
            580                 585                 590         


Glu Glu Ile Ser Glu Ser Val Gly Lys Asn Gln Phe Thr Ser Glu Ser 
        595                 600                 605             


Thr His Leu Asn Val Gly His Arg Ser Val Gly His Ser Ile Ser Ile 
    610                 615                 620                 


Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser Lys Thr Thr His 
625                 630                 635                 640 


Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys Lys Pro Ser Leu 
                645                 650                 655     


Thr Ser Glu Ser Ser Ile His Thr Ile Thr Pro Ser Val Val Asn Phe 
            660                 665                 670         


Thr Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu Gly Ala Val Ser 
        675                 680                 685             


Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu Ser Thr Ser Leu 
    690                 695                 700                 


Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys Pro Arg Trp Thr 
705                 710                 715                 720 


Lys Val Val Ala Arg Ser Thr Cys Arg Ser Pro Lys Gly Leu Glu Leu 
                725                 730                 735     


Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser Ser Leu Ser Asn 
            740                 745                 750         


Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile Gly Pro Pro Ser 
        755                 760                 765             


Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro Lys Leu Ser Lys 
    770                 775                 780                 


Ser Thr Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser Glu Lys Pro Ser 
785                 790                 795                 800 


His Lys Ser Phe Ala Thr His Lys Leu Ser Ser Ser Met Cys Val Ser 
                805                 810                 815     


Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg Gly Arg Pro Lys 
            820                 825                 830         


Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys Arg Thr Leu Lys 
        835                 840                 845             


Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys Glu Glu Gln Glu 
    850                 855                 860                 


Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser Phe Lys Gln Gly 
865                 870                 875                 880 


Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg Pro Lys Arg Gln 
                885                 890                 895     


Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu Ser Val Ala Pro 
            900                 905                 910         


Phe Val Ala Thr Glu Ser Pro Ser Lys Leu Glu Ser Glu Ser Asp Asn 
        915                 920                 925             


His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp Gln Leu Gln Asp 
    930                 935                 940                 


Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val Cys Ser Met Ser 
945                 950                 955                 960 


Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Thr Lys Arg Asn Asn Gly 
                965                 970                 975     


Gln Leu Met Lys Thr Ile Ile Arg Lys Ile Asn Lys Met Lys Thr Leu 
            980                 985                 990         


Lys Arg Lys Lys Leu Leu Asn Gln  Ile Leu Ser Ser Ser  Val Glu Ser 
        995                 1000                 1005             


Ser Asn  Lys Gly Lys Val Gln  Ser Lys Leu His Asn  Thr Val Ser 
    1010                 1015                 1020             


Ser Leu  Ala Ala Thr Phe Gly  Ser Lys Leu Gly Gln  Gln Ile Asn 
    1025                 1030                 1035             


Val Ser  Lys Lys Gly Thr Ile  Tyr Ile Gly Lys Arg  Arg Gly Arg 
    1040                 1045                 1050             


Lys Pro  Lys Thr Val Leu Asn  Gly Ile Leu Ser Gly  Ser Pro Thr 
    1055                 1060                 1065             


Ser Leu  Ala Val Leu Glu Gln  Thr Ala Gln Gln Ala  Ala Gly Ser 
    1070                 1075                 1080             


Ala Leu  Gly Gln Ile Leu Pro  Pro Leu Leu Pro Ser  Ser Ala Ser 
    1085                 1090                 1095             


Ser Ser  Glu Ile Leu Pro Ser  Pro Ile Cys Ser Gln  Ser Ser Gly 
    1100                 1105                 1110             


Thr Ser  Gly Gly Gln Ser Pro  Val Ser Ser Asp Ala  Gly Phe Val 
    1115                 1120                 1125             


Glu Pro  Ser Ser Val Pro Tyr  Leu His Leu His Ser  Arg Gln Gly 
    1130                 1135                 1140             


Ser Met  Ile Gln Thr Leu Ala  Met Lys Lys Ala Ser  Lys Gly Arg 
    1145                 1150                 1155             


Arg Arg  Leu Ser Pro Pro Thr  Leu Leu Pro Asn Ser  Pro Ser His 
    1160                 1165                 1170             


Leu Ser  Glu Leu Thr Ser Leu  Lys Glu Ala Thr Pro  Ser Pro Ile 
    1175                 1180                 1185             


Ser Glu  Ser His Ser Asp Glu  Thr Ile Pro Ser Asp  Ser Gly Ile 
    1190                 1195                 1200             


Gly Thr  Asp Asn Asn Ser Thr  Ser Asp Arg Ala Glu  Lys Phe Cys 
    1205                 1210                 1215             


Gly Gln  Lys Lys Arg Arg His  Ser Phe Glu His Val  Ser Leu Ile 
    1220                 1225                 1230             


Pro Pro  Glu Thr Ser Thr Val  Leu Ser Ser Leu Lys  Glu Lys His 
    1235                 1240                 1245             


Lys His  Lys Cys Lys Arg Arg  Asn His Asp Tyr Leu  Ser Tyr Asp 
    1250                 1255                 1260             


Lys Met  Lys Arg Gln Lys Arg  Lys Arg Lys Lys Lys  Tyr Pro Gln 
    1265                 1270                 1275             


Leu Arg  Asn Arg Gln Asp Pro  Asp Phe Ile Ala Glu  Leu Glu Glu 
    1280                 1285                 1290             


Leu Ile  Ser Arg Leu Ser Glu  Ile Arg Ile Thr His  Arg Ser His 
    1295                 1300                 1305             


His Phe  Ile Pro Arg Asp Leu  Leu Pro Thr Ile Phe  Arg Ile Asn 
    1310                 1315                 1320             


Phe Asn  Ser Phe Tyr Thr His  Pro Ser Phe Pro Leu  Asp Pro Leu 
    1325                 1330                 1335             


His Tyr  Ile Arg Lys Pro Asp  Leu Lys Lys Lys Arg  Gly Arg Pro 
    1340                 1345                 1350             


Pro Lys  Met Arg Glu Ala Met  Ala Glu Met Pro Phe  Met His Ser 
    1355                 1360                 1365             


Leu Ser  Phe Pro Leu Ser Ser  Thr Gly Phe Tyr Pro  Ser Tyr Gly 
    1370                 1375                 1380             


Met Pro  Tyr Ser Pro Ser Pro  Leu Thr Ala Ala Pro  Ile Gly Leu 
    1385                 1390                 1395             


Gly Tyr  Tyr Gly Arg Tyr Pro  Pro Thr Leu Tyr Pro  Pro Pro Pro 
    1400                 1405                 1410             


Ser Pro  Ser Phe Thr Thr Pro  Leu Pro Pro Pro Ser  Tyr Met His 
    1415                 1420                 1425             


Ala Gly  His Leu Leu Leu Asn  Pro Ala Lys Tyr His  Lys Lys Lys 
    1430                 1435                 1440             


His Lys  Leu Leu Arg Gln Glu  Ala Phe Leu Thr Thr  Ser Arg Thr 
    1445                 1450                 1455             


Pro Leu  Leu Ser Met Ser Thr  Tyr Pro Ser Val Pro  Pro Glu Met 
    1460                 1465                 1470             


Ala Tyr  Gly Trp Met Val Glu  His Lys His Arg His  Arg His Lys 
    1475                 1480                 1485             


His Arg  Glu His Arg Ser Ser  Glu Gln Pro Gln Val  Ser Met Asp 
    1490                 1495                 1500             


Thr Gly  Ser Ser Arg Ser Val  Leu Glu Ser Leu Lys  Arg Tyr Arg 
    1505                 1510                 1515             


Phe Gly  Lys Asp Ala Val Gly  Glu Arg Tyr Lys His  Lys Glu Lys 
    1520                 1525                 1530             


His Arg  Cys His Met Ser Cys  Pro His Leu Ser Pro  Ser Lys Ser 
    1535                 1540                 1545             


Leu Ile  Asn Arg Glu Glu Gln  Trp Val His Arg Glu  Pro Ser Glu 
    1550                 1555                 1560             


Ser Ser  Pro Leu Ala Leu Gly  Leu Gln Thr Pro Leu  Gln Ile Asp 
    1565                 1570                 1575             


Cys Ser  Glu Ser Ser Pro Ser  Leu Ser Leu Gly Gly  Phe Thr Pro 
    1580                 1585                 1590             


Asn Ser  Glu Pro Ala Ser Ser  Asp Glu His Thr Asn  Leu Phe Thr 
    1595                 1600                 1605             


Ser Ala  Ile Gly Ser Cys Arg  Val Ser Asn Pro Asn  Ser Ser Gly 
    1610                 1615                 1620             


Arg Lys  Lys Leu Thr Asp Ser  Pro Gly Leu Phe Ser  Ala Gln Asp 
    1625                 1630                 1635             


Thr Ser  Leu Asn Arg Leu His  Arg Lys Glu Ser Leu  Pro Ser Asn 
    1640                 1645                 1650             


Glu Arg  Ala Val Gln Thr Leu  Ala Gly Ser Gln Pro  Thr Ser Asp 
    1655                 1660                 1665             


Lys Pro  Ser Gln Arg Pro Ser  Glu Ser Thr Asn Cys  Ser Pro Thr 
    1670                 1675                 1680             


Arg Lys  Arg Ser Ser Ser Glu  Ser Thr Ser Ser Thr  Val Asn Gly 
    1685                 1690                 1695             


Val Pro  Ser Arg Ser Pro Arg  Leu Val Ala Ser Gly  Asp Asp Ser 
    1700                 1705                 1710             


Val Asp  Ser Leu Leu Gln Arg  Met Val Gln Asn Glu  Asp Gln Glu 
    1715                 1720                 1725             


Pro Met  Glu Lys Ser Ile Asp  Ala Val Ile Ala Thr  Ala Ser Ala 
    1730                 1735                 1740             


Pro Pro  Ser Ser Ser Pro Gly  Arg Ser His Ser Lys  Asp Arg Thr 
    1745                 1750                 1755             


Leu Gly  Lys Pro Asp Ser Leu  Leu Val Pro Ala Val  Thr Ser Asp 
    1760                 1765                 1770             


Ser Cys  Asn Asn Ser Ile Ser  Leu Leu Ser Glu Lys  Leu Thr Ser 
    1775                 1780                 1785             


Ser Cys  Ser Pro His His Ile  Lys Arg Ser Val Val  Glu Ala Met 
    1790                 1795                 1800             


Gln Arg  Gln Ala Arg Lys Met  Cys Asn Tyr Asp Lys  Ile Leu Ala 
    1805                 1810                 1815             


Thr Lys  Lys Asn Leu Asp His  Val Asn Lys Ile Leu  Lys Ala Lys 
    1820                 1825                 1830             


Lys Leu  Gln Arg Gln Ala Arg  Thr Gly Asn Asn Phe  Val Lys Arg 
    1835                 1840                 1845             


Arg Pro  Gly Arg Pro Arg Lys  Cys Pro Leu Gln Ala  Val Val Ser 
    1850                 1855                 1860             


Met Gln  Ala Phe Gln Ala Ala  Gln Phe Val Asn Pro  Glu Leu Asn 
    1865                 1870                 1875             


Arg Asp  Glu Glu Gly Ala Ala  Leu His Leu Ser Pro  Asp Thr Val 
    1880                 1885                 1890             


Thr Asp  Val Ile Glu Ala Val  Val Gln Ser Val Asn  Leu Asn Pro 
    1895                 1900                 1905             


Glu His  Lys Lys Gly Leu Lys  Arg Lys Gly Trp Leu  Leu Glu Glu 
    1910                 1915                 1920             


Gln Thr  Arg Lys Lys Gln Lys  Pro Leu Pro Glu Glu  Glu Glu Gln 
    1925                 1930                 1935             


Glu Asn  Asn Lys Ser Phe Asn  Glu Ala Pro Val Glu  Ile Pro Ser 
    1940                 1945                 1950             


Pro Ser  Glu Thr Pro Ala Lys  Pro Ser Glu Pro Glu  Ser Thr Leu 
    1955                 1960                 1965             


Gln Pro  Val Leu Ser Leu Ile  Pro Arg Glu Lys Lys  Pro Pro Arg 
    1970                 1975                 1980             


Pro Pro  Lys Lys Lys Tyr Gln  Lys Ala Gly Leu Tyr  Ser Asp Val 
    1985                 1990                 1995             


Tyr Lys  Thr Thr Asp Pro Lys  Ser Arg Leu Ile Gln  Leu Lys Lys 
    2000                 2005                 2010             


Glu Lys  Leu Glu Tyr Thr Pro  Gly Glu His Glu Tyr  Gly Leu Phe 
    2015                 2020                 2025             


Pro Ala  Pro Ile His Val Gly  Lys Tyr Leu Arg Gln  Lys Arg Ile 
    2030                 2035                 2040             


Asp Phe  Gln Leu Pro Tyr Asp  Ile Leu Trp Gln Trp  Lys His Asn 
    2045                 2050                 2055             


Gln Leu  Tyr Lys Lys Pro Asp  Val Pro Leu Tyr Lys  Lys Ile Arg 
    2060                 2065                 2070             


Ser Asn  Val Tyr Val Asp Val  Lys Pro Leu Ser Gly  Tyr Glu Ala 
    2075                 2080                 2085             


Thr Thr  Cys Asn Cys Lys Lys  Pro Asp Asp Asp Thr  Arg Lys Gly 
    2090                 2095                 2100             


Cys Val  Asp Asp Cys Leu Asn  Arg Met Ile Phe Ala  Glu Cys Ser 
    2105                 2110                 2115             


Pro Asn  Thr Cys Pro Cys Gly  Glu Gln Cys Cys Asn  Gln Arg Ile 
    2120                 2125                 2130             


Gln Arg  His Glu Trp Val Gln  Cys Leu Glu Arg Phe  Arg Ala Glu 
    2135                 2140                 2145             


Glu Lys  Gly Trp Gly Ile Arg  Thr Lys Glu Pro Leu  Lys Ala Gly 
    2150                 2155                 2160             


Gln Phe  Ile Ile Glu Tyr Leu  Gly Glu Val Val Ser  Glu Gln Glu 
    2165                 2170                 2175             


Phe Arg  Asn Arg Met Ile Glu  Gln Tyr His Asn His  Ser Asp His 
    2180                 2185                 2190             


Tyr Cys  Leu Asn Leu Asp Ser  Gly Met Val Ile Asp  Ser Tyr Arg 
    2195                 2200                 2205             


Met Gly  Asn Glu Ala Arg Phe  Ile Asn His Ser Cys  Asp Pro Asn 
    2210                 2215                 2220             


Cys Glu  Met Gln Lys Trp Ser  Val Asn Gly Val Tyr  Arg Ile Gly 
    2225                 2230                 2235             


Leu Tyr  Ala Leu Lys Asp Met  Pro Ala Gly Thr Glu  Leu Thr Tyr 
    2240                 2245                 2250             


Asp Tyr  Asn Phe His Ser Phe  Asn Val Glu Lys Gln  Gln Leu Cys 
    2255                 2260                 2265             


Lys Cys  Gly Phe Glu Lys Cys  Arg Gly Ile Ile Gly  Gly Lys Ser 
    2270                 2275                 2280             


Gln Arg  Val Asn Gly Leu Thr  Ser Ser Lys Asn Ser  Gln Pro Met 
    2285                 2290                 2295             


Ala Thr  His Lys Lys Ser Gly  Arg Ser Lys Glu Lys  Arg Lys Ser 
    2300                 2305                 2310             


Lys His  Lys Leu Lys Lys Arg  Arg Gly His Leu Ser  Glu Glu Pro 
    2315                 2320                 2325             


Ser Glu  Asn Ile Asn Thr Pro  Thr Arg Leu Thr Pro  Gln Leu Gln 
    2330                 2335                 2340             


Met Lys  Pro Met Ser Asn Arg  Glu Arg Asn Phe Val  Leu Lys His 
    2345                 2350                 2355             


His Val  Phe Leu Val Arg Asn  Trp Glu Lys Ile Arg  Gln Lys Gln 
    2360                 2365                 2370             


Glu Glu  Val Lys His Thr Ser  Asp Asn Ile His Ser  Ala Ser Leu 
    2375                 2380                 2385             


Tyr Thr  Arg Trp Asn Gly Ile  Cys Arg Asp Asp Gly  Asn Ile Lys 
    2390                 2395                 2400             


Ser Asp  Val Phe Met Thr Gln  Phe Ser Ala Leu Gln  Thr Ala Arg 
    2405                 2410                 2415             


Ser Val  Arg Thr Arg Arg Leu  Ala Ala Ala Glu Glu  Asn Ile Glu 
    2420                 2425                 2430             


Val Ala  Arg Ala Ala Arg Leu  Ala Gln Ile Phe Lys  Glu Ile Cys 
    2435                 2440                 2445             


Asp Gly  Ile Ile Ser Tyr Lys  Asp Ser Ser Arg Gln  Ala Leu Ala 
    2450                 2455                 2460             


Ala Pro  Leu Leu Asn Leu Pro  Pro Lys Lys Lys Asn  Ala Asp Tyr 
    2465                 2470                 2475             


Tyr Glu  Lys Ile Ser Asp Pro  Leu Asp Leu Ile Thr  Ile Glu Lys 
    2480                 2485                 2490             


Gln Ile  Leu Thr Gly Tyr Tyr  Lys Thr Val Glu Ala  Phe Asp Ala 
    2495                 2500                 2505             


Asp Met  Leu Lys Val Phe Arg  Asn Ala Glu Lys Tyr  Tyr Gly Arg 
    2510                 2515                 2520             


Lys Ser  Pro Val Gly Arg Asp  Val Cys Arg Leu Arg  Lys Ala Tyr 
    2525                 2530                 2535             


Tyr Asn  Ala Arg His Glu Ala  Ser Ala Gln Ile Asp  Glu Ile Val 
    2540                 2545                 2550             


Gly Glu  Thr Ala Ser Glu Ala  Asp Ser Ser Glu Thr  Ser Val Ser 
    2555                 2560                 2565             


Glu Lys  Glu Asn Gly His Glu  Lys Asp Asp Asp Val  Ile Arg Cys 
    2570                 2575                 2580             


Ile Cys  Gly Leu Tyr Lys Asp  Glu Gly Leu Met Ile  Gln Cys Asp 
    2585                 2590                 2595             


Lys Cys  Met Val Trp Gln His  Cys Asp Cys Met Gly  Val Asn Ser 
    2600                 2605                 2610             


Asp Val  Glu His Tyr Leu Cys  Glu Gln Cys Asp Pro  Arg Pro Val 
    2615                 2620                 2625             


Asp Arg  Glu Val Pro Met Ile  Pro Arg Pro His Tyr  Ala Gln Pro 
    2630                 2635                 2640             


Gly Cys  Val Tyr Phe Ile Cys  Leu Leu Arg Asp Asp  Leu Leu Leu 
    2645                 2650                 2655             


Arg Gln  Gly Asp Cys Val Tyr  Leu Met Arg Asp Ser  Arg Arg Thr 
    2660                 2665                 2670             


Pro Asp  Gly His Pro Val Arg  Gln Ser Tyr Arg Leu  Leu Ser His 
    2675                 2680                 2685             


Ile Asn  Arg Asp Lys Leu Asp  Ile Phe Arg Ile Glu  Lys Leu Trp 
    2690                 2695                 2700             


Lys Asn  Glu Lys Glu Glu Arg  Phe Ala Phe Gly His  His Tyr Phe 
    2705                 2710                 2715             


Arg Pro  His Glu Thr His His  Ser Pro Ser Arg Arg  Phe Tyr His 
    2720                 2725                 2730             


Asn Glu  Leu Phe Arg Val Pro  Leu Tyr Glu Ile Ile  Pro Leu Glu 
    2735                 2740                 2745             


Ala Val  Val Gly Thr Cys Cys  Val Leu Asp Leu Tyr  Thr Tyr Cys 
    2750                 2755                 2760             


Lys Gly  Arg Pro Lys Gly Val  Lys Glu Gln Asp Val  Tyr Ile Cys 
    2765                 2770                 2775             


Asp Tyr  Arg Leu Asp Lys Ser  Ala His Leu Phe Tyr  Lys Ile His 
    2780                 2785                 2790             


Arg Asn  Arg Tyr Pro Val Cys  Thr Lys Pro Tyr Ala  Phe Asp His 
    2795                 2800                 2805             


Phe Pro  Lys Lys Leu Thr Pro  Lys Lys Asp Phe Ser  Pro His Tyr 
    2810                 2815                 2820             


Val Pro  Asp Asn Tyr Lys Arg  Asn Gly Gly Arg Ser  Ser Trp Lys 
    2825                 2830                 2835             


Ser Glu  Arg Ser Lys Pro Pro  Leu Lys Asp Leu Gly  Gln Glu Asp 
    2840                 2845                 2850             


Asp Ala  Leu Pro Leu Ile Glu  Glu Val Leu Ala Ser  Gln Glu Gln 
    2855                 2860                 2865             


Ala Ala  Asn Glu Ile Pro Ser  Leu Glu Glu Pro Glu  Arg Glu Gly 
    2870                 2875                 2880             


Ala Thr  Ala Asn Val Ser Glu  Gly Glu Lys Lys Thr  Glu Glu Ser 
    2885                 2890                 2895             


Ser Gln  Glu Pro Gln Ser Thr  Cys Thr Pro Glu Glu  Arg Arg His 
    2900                 2905                 2910             


Asn Gln  Arg Glu Arg Leu Asn  Gln Ile Leu Leu Asn  Leu Leu Glu 
    2915                 2920                 2925             


Lys Ile  Pro Gly Lys Asn Ala  Ile Asp Val Thr Tyr  Leu Leu Glu 
    2930                 2935                 2940             


Glu Gly  Ser Gly Arg Lys Leu  Arg Arg Arg Thr Leu  Phe Ile Pro 
    2945                 2950                 2955             


Glu Asn  Ser Phe Arg Lys 
    2960                 


<210>  842
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASH2L__Homo_sapiens__NP_001098684

<400>  842

Met Asp Thr Gln Ala Gly Ser Val Asp Glu Glu Asn Gly Arg Gln Leu 
1               5                   10                  15      


Gly Glu Val Glu Leu Gln Cys Gly Ile Cys Thr Lys Trp Phe Thr Ala 
            20                  25                  30          


Asp Thr Phe Gly Ile Asp Thr Ser Ser Cys Leu Pro Phe Met Thr Asn 
        35                  40                  45              


Tyr Ser Phe His Cys Asn Val Cys His His Ser Gly Asn Thr Tyr Phe 
    50                  55                  60                  


Leu Arg Lys Gln Ala Asn Leu Lys Glu Met Cys Leu Ser Ala Leu Ala 
65                  70                  75                  80  


Asn Leu Thr Trp Gln Ser Arg Thr Gln Asp Glu His Pro Lys Thr Met 
                85                  90                  95      


Phe Ser Lys Asp Lys Asp Ile Ile Pro Phe Ile Asp Lys Tyr Trp Glu 
            100                 105                 110         


Cys Met Thr Thr Arg Gln Arg Pro Gly Lys Met Thr Trp Pro Asn Asn 
        115                 120                 125             


Ile Val Lys Thr Met Ser Lys Glu Arg Asp Val Phe Leu Val Lys Glu 
    130                 135                 140                 


His Pro Asp Pro Gly Ser Lys Asp Pro Glu Glu Asp Tyr Pro Lys Phe 
145                 150                 155                 160 


Gly Leu Leu Asp Gln Asp Leu Ser Asn Ile Gly Pro Ala Tyr Asp Asn 
                165                 170                 175     


Gln Lys Gln Ser Ser Ala Val Ser Thr Ser Gly Asn Leu Asn Gly Gly 
            180                 185                 190         


Ile Ala Ala Gly Ser Ser Gly Lys Gly Arg Gly Ala Lys Arg Lys Gln 
        195                 200                 205             


Gln Asp Gly Gly Thr Thr Gly Thr Thr Lys Lys Ala Arg Ser Asp Pro 
    210                 215                 220                 


Leu Phe Ser Ala Gln Arg Leu Pro Pro His Gly Tyr Pro Leu Glu His 
225                 230                 235                 240 


Pro Phe Asn Lys Asp Gly Tyr Arg Tyr Ile Leu Ala Glu Pro Asp Pro 
                245                 250                 255     


His Ala Pro Asp Pro Glu Lys Leu Glu Leu Asp Cys Trp Ala Gly Lys 
            260                 265                 270         


Pro Ile Pro Gly Asp Leu Tyr Arg Ala Cys Leu Tyr Glu Arg Val Leu 
        275                 280                 285             


Leu Ala Leu His Asp Arg Ala Pro Gln Leu Lys Ile Ser Asp Asp Arg 
    290                 295                 300                 


Leu Thr Val Val Gly Glu Lys Gly Tyr Ser Met Val Arg Ala Ser His 
305                 310                 315                 320 


Gly Val Arg Lys Gly Ala Trp Tyr Phe Glu Ile Thr Val Asp Glu Met 
                325                 330                 335     


Pro Pro Asp Thr Ala Ala Arg Leu Gly Trp Ser Gln Pro Leu Gly Asn 
            340                 345                 350         


Leu Gln Ala Pro Leu Gly Tyr Asp Lys Phe Ser Tyr Ser Trp Arg Ser 
        355                 360                 365             


Lys Lys Gly Thr Lys Phe His Gln Ser Ile Gly Lys His Tyr Ser Ser 
    370                 375                 380                 


Gly Tyr Gly Gln Gly Asp Val Leu Gly Phe Tyr Ile Asn Leu Pro Glu 
385                 390                 395                 400 


Asp Thr Glu Thr Ala Lys Ser Leu Pro Asp Thr Tyr Lys Asp Lys Ala 
                405                 410                 415     


Leu Ile Lys Phe Lys Ser Tyr Leu Tyr Phe Glu Glu Lys Asp Phe Val 
            420                 425                 430         


Asp Lys Ala Glu Lys Ser Leu Lys Gln Thr Pro His Ser Glu Ile Ile 
        435                 440                 445             


Phe Tyr Lys Asn Gly Val Asn Gln Gly Val Ala Tyr Lys Asp Ile Phe 
    450                 455                 460                 


Glu Gly Val Tyr Phe Pro Ala Ile Ser Leu Tyr Lys Ser Cys Thr Val 
465                 470                 475                 480 


Ser Ile Asn Phe Gly Pro Cys Phe Lys Tyr Pro Pro Lys Asp Leu Thr 
                485                 490                 495     


Tyr Arg Pro Met Ser Asp Met Gly Trp Gly Ala Val Val Glu His Thr 
            500                 505                 510         


Leu Ala Asp Val Leu Tyr His Val Glu Thr Glu Val Asp Gly Arg Arg 
        515                 520                 525             


Ser Pro Pro Trp Glu Pro 
    530                 


<210>  843
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASIC1__Homo_sapiens__NP_001086

<400>  843

Met Glu Leu Lys Ala Glu Glu Glu Glu Val Gly Gly Val Gln Pro Val 
1               5                   10                  15      


Ser Ile Gln Ala Phe Ala Ser Ser Ser Thr Leu His Gly Leu Ala His 
            20                  25                  30          


Ile Phe Ser Tyr Glu Arg Leu Ser Leu Lys Arg Ala Leu Trp Ala Leu 
        35                  40                  45              


Cys Phe Leu Gly Ser Leu Ala Val Leu Leu Cys Val Cys Thr Glu Arg 
    50                  55                  60                  


Val Gln Tyr Tyr Phe His Tyr His His Val Thr Lys Leu Asp Glu Val 
65                  70                  75                  80  


Ala Ala Ser Gln Leu Thr Phe Pro Ala Val Thr Leu Cys Asn Leu Asn 
                85                  90                  95      


Glu Phe Arg Phe Ser Gln Val Ser Lys Asn Asp Leu Tyr His Ala Gly 
            100                 105                 110         


Glu Leu Leu Ala Leu Leu Asn Asn Arg Tyr Glu Ile Pro Asp Thr Gln 
        115                 120                 125             


Met Ala Asp Glu Lys Gln Leu Glu Ile Leu Gln Asp Lys Ala Asn Phe 
    130                 135                 140                 


Arg Ser Phe Lys Pro Lys Pro Phe Asn Met Arg Glu Phe Tyr Asp Arg 
145                 150                 155                 160 


Ala Gly His Asp Ile Arg Asp Met Leu Leu Ser Cys His Phe Arg Gly 
                165                 170                 175     


Glu Val Cys Ser Ala Glu Asp Phe Lys Val Val Phe Thr Arg Tyr Gly 
            180                 185                 190         


Lys Cys Tyr Thr Phe Asn Ser Gly Arg Asp Gly Arg Pro Arg Leu Lys 
        195                 200                 205             


Thr Met Lys Gly Gly Thr Gly Asn Gly Leu Glu Ile Met Leu Asp Ile 
    210                 215                 220                 


Gln Gln Asp Glu Tyr Leu Pro Val Trp Gly Glu Thr Asp Glu Thr Ser 
225                 230                 235                 240 


Phe Glu Ala Gly Ile Lys Val Gln Ile His Ser Gln Asp Glu Pro Pro 
                245                 250                 255     


Phe Ile Asp Gln Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Thr Phe 
            260                 265                 270         


Val Ala Cys Gln Glu Gln Arg Leu Ile Tyr Leu Pro Pro Pro Trp Gly 
        275                 280                 285             


Thr Cys Lys Ala Val Thr Met Asp Ser Asp Leu Asp Phe Phe Asp Ser 
    290                 295                 300                 


Tyr Ser Ile Thr Ala Cys Arg Ile Asp Cys Glu Thr Arg Tyr Leu Val 
305                 310                 315                 320 


Glu Asn Cys Asn Cys Arg Met Val His Met Pro Gly Asp Ala Pro Tyr 
                325                 330                 335     


Cys Thr Pro Glu Gln Tyr Lys Glu Cys Ala Asp Pro Ala Leu Asp Phe 
            340                 345                 350         


Leu Val Glu Lys Asp Gln Glu Tyr Cys Val Cys Glu Met Pro Cys Asn 
        355                 360                 365             


Leu Thr Arg Tyr Gly Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys 
    370                 375                 380                 


Ala Ser Ala Lys Tyr Leu Ala Lys Lys Phe Asn Lys Ser Glu Gln Tyr 
385                 390                 395                 400 


Ile Gly Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Val Leu Asn 
                405                 410                 415     


Tyr Glu Thr Ile Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly Leu Leu 
            420                 425                 430         


Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu 
        435                 440                 445             


Thr Val Leu Glu Leu Phe Asp Tyr Ala Tyr Glu Val Ile Lys His Lys 
    450                 455                 460                 


Leu Cys Arg Arg Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser Ser Ala 
465                 470                 475                 480 


Asp Lys Gly Val Ala Leu Ser Leu Asp Asp Val Lys Arg His Asn Pro 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly His Pro Ala Gly Met Thr Tyr Ala Ala Asn 
            500                 505                 510         


Ile Leu Pro His His Pro Ala Arg Gly Thr Phe Glu Asp Phe Thr Cys 
        515                 520                 525             


<210>  844
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASIC2__Homo_sapiens__NP_001085

<400>  844

Met Asp Leu Lys Glu Ser Pro Ser Glu Gly Ser Leu Gln Pro Ser Ser 
1               5                   10                  15      


Ile Gln Ile Phe Ala Asn Thr Ser Thr Leu His Gly Ile Arg His Ile 
            20                  25                  30          


Phe Val Tyr Gly Pro Leu Thr Ile Arg Arg Val Leu Trp Ala Val Ala 
        35                  40                  45              


Phe Val Gly Ser Leu Gly Leu Leu Leu Val Glu Ser Ser Glu Arg Val 
    50                  55                  60                  


Ser Tyr Tyr Phe Ser Tyr Gln His Val Thr Lys Val Asp Glu Val Val 
65                  70                  75                  80  


Ala Gln Ser Leu Val Phe Pro Ala Val Thr Leu Cys Asn Leu Asn Gly 
                85                  90                  95      


Phe Arg Phe Ser Arg Leu Thr Thr Asn Asp Leu Tyr His Ala Gly Glu 
            100                 105                 110         


Leu Leu Ala Leu Leu Asp Val Asn Leu Gln Ile Pro Asp Pro His Leu 
        115                 120                 125             


Ala Asp Pro Ser Val Leu Glu Ala Leu Arg Gln Lys Ala Asn Phe Lys 
    130                 135                 140                 


His Tyr Lys Pro Lys Gln Phe Ser Met Leu Glu Phe Leu His Arg Val 
145                 150                 155                 160 


Gly His Asp Leu Lys Asp Met Met Leu Tyr Cys Lys Phe Lys Gly Gln 
                165                 170                 175     


Glu Cys Gly His Gln Asp Phe Thr Thr Val Phe Thr Lys Tyr Gly Lys 
            180                 185                 190         


Cys Tyr Met Phe Asn Ser Gly Glu Asp Gly Lys Pro Leu Leu Thr Thr 
        195                 200                 205             


Val Lys Gly Gly Thr Gly Asn Gly Leu Glu Ile Met Leu Asp Ile Gln 
    210                 215                 220                 


Gln Asp Glu Tyr Leu Pro Ile Trp Gly Glu Thr Glu Glu Thr Thr Phe 
225                 230                 235                 240 


Glu Ala Gly Val Lys Val Gln Ile His Ser Gln Ser Glu Pro Pro Phe 
                245                 250                 255     


Ile Gln Glu Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Thr Phe Val 
            260                 265                 270         


Ala Thr Gln Glu Gln Arg Leu Thr Tyr Leu Pro Pro Pro Trp Gly Glu 
        275                 280                 285             


Cys Arg Ser Ser Glu Met Gly Leu Asp Phe Phe Pro Val Tyr Ser Ile 
    290                 295                 300                 


Thr Ala Cys Arg Ile Asp Cys Glu Thr Arg Tyr Ile Val Glu Asn Cys 
305                 310                 315                 320 


Asn Cys Arg Met Val His Met Pro Gly Asp Ala Pro Phe Cys Thr Pro 
                325                 330                 335     


Glu Gln His Lys Glu Cys Ala Glu Pro Ala Leu Gly Leu Leu Ala Glu 
            340                 345                 350         


Lys Asp Ser Asn Tyr Cys Leu Cys Arg Thr Pro Cys Asn Leu Thr Arg 
        355                 360                 365             


Tyr Asn Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys Thr Ser Ala 
    370                 375                 380                 


Lys Tyr Leu Glu Lys Lys Phe Asn Lys Ser Glu Lys Tyr Ile Ser Glu 
385                 390                 395                 400 


Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Ala Leu Asn Tyr Glu Thr 
                405                 410                 415     


Ile Glu Gln Lys Lys Ala Tyr Glu Val Ala Ala Leu Leu Gly Asp Ile 
            420                 425                 430         


Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu Thr Ile Leu 
        435                 440                 445             


Glu Leu Phe Asp Tyr Ile Tyr Glu Leu Ile Lys Glu Lys Leu Leu Asp 
    450                 455                 460                 


Leu Leu Gly Lys Glu Glu Asp Glu Gly Ser His Asp Glu Asn Val Ser 
465                 470                 475                 480 


Thr Cys Asp Thr Met Pro Asn His Ser Glu Thr Ile Ser His Thr Val 
                485                 490                 495     


Asn Val Pro Leu Gln Thr Thr Leu Gly Thr Leu Glu Glu Ile Ala Cys 
            500                 505                 510         


<210>  845
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASIC3__Homo_sapiens__NP_004760

<400>  845

Met Lys Pro Thr Ser Gly Pro Glu Glu Ala Arg Arg Pro Ala Ser Asp 
1               5                   10                  15      


Ile Arg Val Phe Ala Ser Asn Cys Ser Met His Gly Leu Gly His Val 
            20                  25                  30          


Phe Gly Pro Gly Ser Leu Ser Leu Arg Arg Gly Met Trp Ala Ala Ala 
        35                  40                  45              


Val Val Leu Ser Val Ala Thr Phe Leu Tyr Gln Val Ala Glu Arg Val 
    50                  55                  60                  


Arg Tyr Tyr Arg Glu Phe His His Gln Thr Ala Leu Asp Glu Arg Glu 
65                  70                  75                  80  


Ser His Arg Leu Ile Phe Pro Ala Val Thr Leu Cys Asn Ile Asn Pro 
                85                  90                  95      


Leu Arg Arg Ser Arg Leu Thr Pro Asn Asp Leu His Trp Ala Gly Ser 
            100                 105                 110         


Ala Leu Leu Gly Leu Asp Pro Ala Glu His Ala Ala Phe Leu Arg Ala 
        115                 120                 125             


Leu Gly Arg Pro Pro Ala Pro Pro Gly Phe Met Pro Ser Pro Thr Phe 
    130                 135                 140                 


Asp Met Ala Gln Leu Tyr Ala Arg Ala Gly His Ser Leu Asp Asp Met 
145                 150                 155                 160 


Leu Leu Asp Cys Arg Phe Arg Gly Gln Pro Cys Gly Pro Glu Asn Phe 
                165                 170                 175     


Thr Thr Ile Phe Thr Arg Met Gly Lys Cys Tyr Thr Phe Asn Ser Gly 
            180                 185                 190         


Ala Asp Gly Ala Glu Leu Leu Thr Thr Thr Arg Gly Gly Met Gly Asn 
        195                 200                 205             


Gly Leu Asp Ile Met Leu Asp Val Gln Gln Glu Glu Tyr Leu Pro Val 
    210                 215                 220                 


Trp Arg Asp Asn Glu Glu Thr Pro Phe Glu Val Gly Ile Arg Val Gln 
225                 230                 235                 240 


Ile His Ser Gln Glu Glu Pro Pro Ile Ile Asp Gln Leu Gly Leu Gly 
                245                 250                 255     


Val Ser Pro Gly Tyr Gln Thr Phe Val Ser Cys Gln Gln Gln Gln Leu 
            260                 265                 270         


Ser Phe Leu Pro Pro Pro Trp Gly Asp Cys Ser Ser Ala Ser Leu Asn 
        275                 280                 285             


Pro Asn Tyr Glu Pro Glu Pro Ser Asp Pro Leu Gly Ser Pro Ser Pro 
    290                 295                 300                 


Ser Pro Ser Pro Pro Tyr Thr Leu Met Gly Cys Arg Leu Ala Cys Glu 
305                 310                 315                 320 


Thr Arg Tyr Val Ala Arg Lys Cys Gly Cys Arg Met Val Tyr Met Pro 
                325                 330                 335     


Gly Asp Val Pro Val Cys Ser Pro Gln Gln Tyr Lys Asn Cys Ala His 
            340                 345                 350         


Pro Ala Ile Asp Ala Met Leu Arg Lys Asp Ser Cys Ala Cys Pro Asn 
        355                 360                 365             


Pro Cys Ala Ser Thr Arg Tyr Ala Lys Glu Leu Ser Met Val Arg Ile 
    370                 375                 380                 


Pro Ser Arg Ala Ala Ala Arg Phe Leu Ala Arg Lys Leu Asn Arg Ser 
385                 390                 395                 400 


Glu Ala Tyr Ile Ala Glu Asn Val Leu Ala Leu Asp Ile Phe Phe Glu 
                405                 410                 415     


Ala Leu Asn Tyr Glu Thr Val Glu Gln Lys Lys Ala Tyr Glu Met Ser 
            420                 425                 430         


Glu Leu Leu Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala 
        435                 440                 445             


Ser Leu Leu Thr Ile Leu Glu Ile Leu Asp Tyr Leu Cys Glu Val Phe 
    450                 455                 460                 


Arg Asp Lys Val Leu Gly Tyr Phe Trp Asn Arg Gln His Ser Gln Arg 
465                 470                 475                 480 


His Ser Ser Thr Asn Leu Leu Gln Glu Gly Leu Gly Ser His Arg Thr 
                485                 490                 495     


Gln Val Pro His Leu Ser Leu Gly Pro Arg Pro Pro Thr Pro Pro Cys 
            500                 505                 510         


Ala Val Thr Lys Thr Leu Ser Ala Ser His Arg Thr Cys Tyr Leu Val 
        515                 520                 525             


Thr Gln Leu 
    530     


<210>  846
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASIC4__Homo_sapiens__NP_878267

<400>  846

Met Leu Ser Gly Ala Ala Gly Ala Ala Arg Arg Gly Gly Ala Ala Leu 
1               5                   10                  15      


Ala Pro Ser Leu Thr Arg Ser Leu Ala Gly Thr His Ala Gly Ala Asp 
            20                  25                  30          


Ser Cys Ala Gly Ala Asp Lys Gly Ser His Lys Glu Thr Ile Glu Glu 
        35                  40                  45              


Arg Asp Lys Arg Gln Gln Arg Gln Gln Arg Gln Arg Gln His Gln Gly 
    50                  55                  60                  


Cys Gly Ala Ala Gly Ser Gly Ser Asp Ser Pro Thr Ser Gly Pro His 
65                  70                  75                  80  


Pro Val Pro Val Leu Phe Pro Leu Ala Leu Ser Leu Glu Glu Gln Pro 
                85                  90                  95      


Leu Pro Pro Leu Pro Leu Gly Arg Ala Pro Gly Leu Leu Ala Arg Glu 
            100                 105                 110         


Gly Gln Gly Arg Glu Ala Leu Ala Ser Pro Ser Ser Arg Gly Gln Met 
        115                 120                 125             


Pro Ile Glu Ile Val Cys Lys Ile Lys Phe Ala Glu Glu Asp Ala Lys 
    130                 135                 140                 


Pro Lys Glu Lys Glu Ala Gly Asp Glu Gln Ser Leu Leu Gly Ala Val 
145                 150                 155                 160 


Ala Pro Gly Ala Ala Pro Arg Asp Leu Ala Thr Phe Ala Ser Thr Ser 
                165                 170                 175     


Thr Leu His Gly Leu Gly Arg Ala Cys Gly Pro Gly Pro His Gly Leu 
            180                 185                 190         


Arg Arg Thr Leu Trp Ala Leu Ala Leu Leu Thr Ser Leu Ala Ala Phe 
        195                 200                 205             


Leu Tyr Gln Ala Ala Gly Leu Ala Arg Gly Tyr Leu Thr Arg Pro His 
    210                 215                 220                 


Leu Val Ala Met Asp Pro Ala Ala Pro Ala Pro Val Ala Gly Phe Pro 
225                 230                 235                 240 


Ala Val Thr Leu Cys Asn Ile Asn Arg Phe Arg His Ser Ala Leu Ser 
                245                 250                 255     


Asp Ala Asp Ile Phe His Leu Ala Asn Leu Thr Gly Leu Pro Pro Lys 
            260                 265                 270         


Asp Arg Asp Gly His Arg Ala Ala Gly Leu Arg Tyr Pro Glu Pro Asp 
        275                 280                 285             


Met Val Asp Ile Leu Asn Arg Thr Gly His Gln Leu Ala Asp Met Leu 
    290                 295                 300                 


Lys Ser Cys Asn Phe Ser Gly His His Cys Ser Ala Ser Asn Phe Ser 
305                 310                 315                 320 


Val Val Tyr Thr Arg Tyr Gly Lys Cys Tyr Thr Phe Asn Ala Asp Pro 
                325                 330                 335     


Arg Ser Ser Leu Pro Ser Arg Ala Gly Gly Met Gly Ser Gly Leu Glu 
            340                 345                 350         


Ile Met Leu Asp Ile Gln Gln Glu Glu Tyr Leu Pro Ile Trp Arg Glu 
        355                 360                 365             


Thr Asn Glu Thr Ser Phe Glu Ala Gly Ile Arg Val Gln Ile His Ser 
    370                 375                 380                 


Gln Glu Glu Pro Pro Tyr Ile His Gln Leu Gly Phe Gly Val Ser Pro 
385                 390                 395                 400 


Gly Phe Gln Thr Phe Val Ser Cys Gln Glu Gln Arg Leu Thr Tyr Leu 
                405                 410                 415     


Pro Gln Pro Trp Gly Asn Cys Arg Ala Glu Ser Glu Leu Arg Glu Pro 
            420                 425                 430         


Glu Leu Gln Gly Tyr Ser Ala Tyr Ser Val Ser Ala Cys Arg Leu Arg 
        435                 440                 445             


Cys Glu Lys Glu Ala Val Leu Gln Arg Cys His Cys Arg Met Val His 
    450                 455                 460                 


Met Pro Asp Ser Leu Gly Gly Gly Pro Glu Gly Pro Cys Phe Cys Pro 
465                 470                 475                 480 


Thr Pro Cys Asn Leu Thr Arg Tyr Gly Lys Glu Ile Ser Met Val Arg 
                485                 490                 495     


Ile Pro Asn Arg Gly Ser Ala Arg Tyr Leu Ala Arg Lys Tyr Asn Arg 
            500                 505                 510         


Asn Glu Thr Tyr Ile Arg Glu Asn Phe Leu Val Leu Asp Val Phe Phe 
        515                 520                 525             


Glu Ala Leu Thr Ser Glu Ala Met Glu Gln Arg Ala Ala Tyr Gly Leu 
    530                 535                 540                 


Ser Ala Leu Leu Gly Asp Leu Gly Gly Gln Met Gly Leu Phe Ile Gly 
545                 550                 555                 560 


Ala Ser Ile Leu Thr Leu Leu Glu Ile Leu Asp Tyr Ile Tyr Glu Val 
                565                 570                 575     


Ser Trp Asp Arg Leu Lys Arg Val Trp Arg Arg Pro Lys Thr Pro Leu 
            580                 585                 590         


Arg Thr Ser Thr Gly Gly Ile Ser Thr Leu Gly Leu Gln Glu Leu Lys 
        595                 600                 605             


Glu Gln Ser Pro Cys Pro Ser Arg Gly Arg Val Glu Gly Gly Gly Val 
    610                 615                 620                 


Ser Ser Leu Leu Pro Asn His His His Pro His Gly Pro Pro Gly Gly 
625                 630                 635                 640 


Leu Phe Glu Asp Phe Ala Cys 
                645         


<210>  847
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASIC5__Homo_sapiens__NP_059115

<400>  847

Met Glu Gln Thr Glu Lys Ser Lys Val Tyr Ala Glu Asn Gly Leu Leu 
1               5                   10                  15      


Glu Lys Ile Lys Leu Cys Leu Ser Lys Lys Pro Leu Pro Ser Pro Thr 
            20                  25                  30          


Glu Arg Lys Lys Phe Asp His Asp Phe Ala Ile Ser Thr Ser Phe His 
        35                  40                  45              


Gly Ile His Asn Ile Val Gln Asn Arg Ser Lys Ile Arg Arg Val Leu 
    50                  55                  60                  


Trp Leu Val Val Val Leu Gly Ser Val Ser Leu Val Thr Trp Gln Ile 
65                  70                  75                  80  


Tyr Ile Arg Leu Leu Asn Tyr Phe Thr Trp Pro Thr Thr Thr Ser Ile 
                85                  90                  95      


Glu Val Gln Tyr Val Glu Lys Met Glu Phe Pro Ala Val Thr Phe Cys 
            100                 105                 110         


Asn Leu Asn Arg Phe Gln Thr Asp Ala Val Ala Lys Phe Gly Val Ile 
        115                 120                 125             


Phe Phe Leu Trp His Ile Val Ser Lys Val Leu His Leu Gln Glu Ile 
    130                 135                 140                 


Thr Ala Asn Ser Thr Gly Ser Arg Glu Ala Thr Asp Phe Ala Ala Ser 
145                 150                 155                 160 


His Gln Asn Phe Ser Ile Val Glu Phe Ile Arg Asn Lys Gly Phe Tyr 
                165                 170                 175     


Leu Asn Asn Ser Thr Leu Leu Asp Cys Glu Phe Phe Gly Lys Pro Cys 
            180                 185                 190         


Ser Pro Lys Asp Phe Ala His Val Phe Thr Glu Tyr Gly Asn Cys Phe 
        195                 200                 205             


Thr Phe Asn His Gly Glu Thr Leu Gln Ala Lys Arg Lys Val Ser Val 
    210                 215                 220                 


Ser Gly Arg Gly Leu Ser Leu Leu Phe Asn Val Asn Gln Glu Ala Phe 
225                 230                 235                 240 


Thr Asp Asn Pro Ala Leu Gly Phe Val Asp Ala Gly Ile Ile Phe Val 
                245                 250                 255     


Ile His Ser Pro Lys Lys Val Pro Gln Phe Asp Gly Leu Gly Leu Leu 
            260                 265                 270         


Ser Pro Val Gly Met His Ala Arg Val Thr Ile Arg Gln Val Lys Thr 
        275                 280                 285             


Val His Gln Glu Tyr Pro Trp Gly Glu Cys Asn Pro Asn Ile Lys Leu 
    290                 295                 300                 


Gln Asn Phe Ser Ser Tyr Ser Thr Ser Gly Cys Leu Lys Glu Cys Lys 
305                 310                 315                 320 


Ala Gln His Ile Lys Lys Gln Cys Gly Cys Val Pro Phe Leu Leu Pro 
                325                 330                 335     


Gly Tyr Gly Ile Glu Cys Asp Leu Gln Lys Tyr Phe Ser Cys Val Ser 
            340                 345                 350         


Pro Val Leu Asp His Ile Glu Phe Lys Asp Leu Cys Thr Val Gly Thr 
        355                 360                 365             


His Asn Ser Ser Cys Pro Val Ser Cys Glu Glu Ile Glu Tyr Pro Ala 
    370                 375                 380                 


Thr Ile Ser Tyr Ser Ser Phe Pro Ser Gln Lys Ala Leu Lys Tyr Leu 
385                 390                 395                 400 


Ser Lys Lys Leu Asn Gln Ser Arg Lys Tyr Ile Arg Glu Asn Leu Val 
                405                 410                 415     


Lys Ile Glu Ile Asn Tyr Ser Asp Leu Asn Tyr Lys Ile Thr Gln Gln 
            420                 425                 430         


Gln Lys Ala Val Ser Val Ser Glu Leu Leu Ala Asp Leu Gly Gly Gln 
        435                 440                 445             


Leu Gly Leu Phe Cys Gly Ala Ser Leu Ile Thr Ile Ile Glu Ile Ile 
    450                 455                 460                 


Glu Tyr Leu Phe Thr Asn Phe Tyr Trp Ile Cys Ile Phe Phe Leu Leu 
465                 470                 475                 480 


Lys Ile Ser Glu Met Thr Gln Trp Thr Pro Pro Pro Gln Asn His Leu 
                485                 490                 495     


Gly Asn Lys Asn Arg Ile Glu Glu Cys 
            500                 505 


<210>  848
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASIP__Homo_sapiens__XP_005260469

<400>  848

Met Pro Pro Gly Met Asp Val Thr Arg Leu Leu Leu Ala Thr Leu Leu 
1               5                   10                  15      


Val Phe Leu Cys Phe Phe Thr Ala Asn Ser His Leu Pro Pro Glu Glu 
            20                  25                  30          


Lys Leu Arg Asp Asp Arg Ser Leu Arg Ser Asn Ser Ser Val Asn Leu 
        35                  40                  45              


Leu Asp Val Pro Ser Val Ser Ile Val Ala Leu Asn Lys Lys Ser Lys 
    50                  55                  60                  


Gln Ile Gly Arg Lys Ala Ala Glu Lys Lys Arg Ser Ser Lys Lys Glu 
65                  70                  75                  80  


Ala Ser Met Lys Lys Val Val Arg Pro Arg Thr Pro Leu Ser Ala Pro 
                85                  90                  95      


Cys Val Ala Thr Arg Asn Ser Cys Lys Pro Pro Ala Pro Ala Cys Cys 
            100                 105                 110         


Asp Pro Cys Ala Ser Cys Gln Cys Arg Phe Phe Arg Ser Ala Cys Ser 
        115                 120                 125             


Cys Arg Val Leu Ser Leu Asn Cys 
    130                 135     


<210>  849
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASL__Homo_sapiens__NP_000039

<400>  849

Met Ala Ser Glu Ser Gly Lys Leu Trp Gly Gly Arg Phe Val Gly Ala 
1               5                   10                  15      


Val Asp Pro Ile Met Glu Lys Phe Asn Ala Ser Ile Ala Tyr Asp Arg 
            20                  25                  30          


His Leu Trp Glu Val Asp Val Gln Gly Ser Lys Ala Tyr Ser Arg Gly 
        35                  40                  45              


Leu Glu Lys Ala Gly Leu Leu Thr Lys Ala Glu Met Asp Gln Ile Leu 
    50                  55                  60                  


His Gly Leu Asp Lys Val Ala Glu Glu Trp Ala Gln Gly Thr Phe Lys 
65                  70                  75                  80  


Leu Asn Ser Asn Asp Glu Asp Ile His Thr Ala Asn Glu Arg Arg Leu 
                85                  90                  95      


Lys Glu Leu Ile Gly Ala Thr Ala Gly Lys Leu His Thr Gly Arg Ser 
            100                 105                 110         


Arg Asn Asp Gln Val Val Thr Asp Leu Arg Leu Trp Met Arg Gln Thr 
        115                 120                 125             


Cys Ser Thr Leu Ser Gly Leu Leu Trp Glu Leu Ile Arg Thr Met Val 
    130                 135                 140                 


Asp Arg Ala Glu Ala Glu Arg Asp Val Leu Phe Pro Gly Tyr Thr His 
145                 150                 155                 160 


Leu Gln Arg Ala Gln Pro Ile Arg Trp Ser His Trp Ile Leu Ser His 
                165                 170                 175     


Ala Val Ala Leu Thr Arg Asp Ser Glu Arg Leu Leu Glu Val Arg Lys 
            180                 185                 190         


Arg Ile Asn Val Leu Pro Leu Gly Ser Gly Ala Ile Ala Gly Asn Pro 
        195                 200                 205             


Leu Gly Val Asp Arg Glu Leu Leu Arg Ala Glu Leu Asn Phe Gly Ala 
    210                 215                 220                 


Ile Thr Leu Asn Ser Met Asp Ala Thr Ser Glu Arg Asp Phe Val Ala 
225                 230                 235                 240 


Glu Phe Leu Phe Trp Ala Ser Leu Cys Met Thr His Leu Ser Arg Met 
                245                 250                 255     


Ala Glu Asp Leu Ile Leu Tyr Cys Thr Lys Glu Phe Ser Phe Val Gln 
            260                 265                 270         


Leu Ser Asp Ala Tyr Ser Thr Gly Ser Ser Leu Met Pro Gln Lys Lys 
        275                 280                 285             


Asn Pro Asp Ser Leu Glu Leu Ile Arg Ser Lys Ala Gly Arg Val Phe 
    290                 295                 300                 


Gly Arg Cys Ala Gly Leu Leu Met Thr Leu Lys Gly Leu Pro Ser Thr 
305                 310                 315                 320 


Tyr Asn Lys Asp Leu Gln Glu Asp Lys Glu Ala Val Phe Glu Val Ser 
                325                 330                 335     


Asp Thr Met Ser Ala Val Leu Gln Val Ala Thr Gly Val Ile Ser Thr 
            340                 345                 350         


Leu Gln Ile His Gln Glu Asn Met Gly Gln Ala Leu Ser Pro Asp Met 
        355                 360                 365             


Leu Ala Thr Asp Leu Ala Tyr Tyr Leu Val Arg Lys Gly Met Pro Phe 
    370                 375                 380                 


Arg Gln Ala His Glu Ala Ser Gly Lys Ala Val Phe Met Ala Glu Thr 
385                 390                 395                 400 


Lys Gly Val Ala Leu Asn Gln Leu Ser Leu Gln Glu Leu Gln Thr Ile 
                405                 410                 415     


Ser Pro Leu Phe Ser Gly Asp Val Ile Cys Val Trp Asp Tyr Gly His 
            420                 425                 430         


Ser Val Glu Gln Tyr Gly Ala Leu Gly Gly Thr Ala Arg Ser Ser Val 
        435                 440                 445             


Asp Trp Gln Ile Arg Gln Val Arg Ala Leu Leu Gln Ala Gln Gln Ala 
    450                 455                 460                 


<210>  850
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASMT__Homo_sapiens__NP_001164510

<400>  850

Met Gly Ser Ser Glu Asp Gln Ala Tyr Arg Leu Leu Asn Asp Tyr Ala 
1               5                   10                  15      


Asn Gly Phe Met Val Ser Gln Val Leu Phe Ala Ala Cys Glu Leu Gly 
            20                  25                  30          


Val Phe Asp Leu Leu Ala Glu Ala Pro Gly Pro Leu Asp Val Ala Ala 
        35                  40                  45              


Val Ala Ala Gly Val Arg Ala Ser Ala His Gly Thr Glu Leu Leu Leu 
    50                  55                  60                  


Asp Ile Cys Val Ser Leu Lys Leu Leu Lys Val Glu Thr Arg Gly Gly 
65                  70                  75                  80  


Lys Ala Phe Tyr Arg Asn Thr Glu Leu Ser Ser Asp Tyr Leu Thr Thr 
                85                  90                  95      


Val Ser Pro Thr Ser Gln Cys Ser Met Leu Lys Tyr Met Gly Arg Thr 
            100                 105                 110         


Ser Tyr Arg Cys Trp Gly His Leu Ala Asp Ala Val Arg Glu Gly Arg 
        115                 120                 125             


Asn Gln Tyr Leu Glu Thr Phe Gly Val Pro Ala Glu Glu Leu Phe Thr 
    130                 135                 140                 


Ala Ile Tyr Arg Ser Glu Gly Glu Arg Leu Gln Phe Met Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Val Trp Ser Val Asn Gly Arg Ser Val Leu Thr Ala Phe Asp 
                165                 170                 175     


Leu Ser Val Phe Pro Leu Met Cys Asp Leu Gly Gly Asp Phe Phe Lys 
            180                 185                 190         


Asp Pro Leu Pro Glu Ala Asp Leu Tyr Ile Leu Ala Arg Val Leu His 
        195                 200                 205             


Asp Trp Ala Asp Gly Lys Cys Ser His Leu Leu Glu Arg Ile Tyr His 
    210                 215                 220                 


Thr Cys Lys Pro Gly Gly Gly Ile Leu Val Ile Glu Ser Leu Leu Asp 
225                 230                 235                 240 


Glu Asp Arg Arg Gly Pro Leu Leu Thr Gln Leu Tyr Ser Leu Asn Met 
                245                 250                 255     


Leu Val Gln Thr Glu Gly Gln Glu Arg Thr Pro Thr His Tyr His Met 
            260                 265                 270         


Leu Leu Ser Ser Ala Gly Phe Arg Asp Phe Gln Phe Lys Lys Thr Gly 
        275                 280                 285             


Ala Ile Tyr Asp Ala Ile Leu Ala Arg Lys 
    290                 295             


<210>  851
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASMTL__Homo_sapiens__NP_001166945

<400>  851

Met Val Leu Cys Pro Val Ile Gly Lys Leu Leu His Lys Arg Val Val 
1               5                   10                  15      


Leu Ala Ser Ala Ser Pro Arg Arg Gln Glu Ile Leu Ser Asn Ala Gly 
            20                  25                  30          


Leu Arg Phe Glu Val Val Pro Ser Lys Phe Lys Glu Lys Leu Asp Lys 
        35                  40                  45              


Ala Ser Phe Ala Thr Pro Tyr Gly Tyr Ala Met Glu Thr Ala Lys Gln 
    50                  55                  60                  


Lys Ala Leu Glu Val Ala Asn Arg Leu Tyr Gln Thr Val Gly Gly Leu 
65                  70                  75                  80  


Ile Leu Glu Lys Pro Val Asp Lys Gln Asp Ala Tyr Arg Met Leu Ser 
                85                  90                  95      


Arg Leu Ser Gly Arg Glu His Ser Val Phe Thr Gly Val Ala Ile Val 
            100                 105                 110         


His Cys Ser Ser Lys Asp His Gln Leu Asp Thr Arg Val Ser Glu Phe 
        115                 120                 125             


Tyr Glu Glu Thr Lys Val Lys Phe Ser Glu Leu Ser Glu Glu Leu Leu 
    130                 135                 140                 


Trp Glu Tyr Val His Ser Gly Glu Pro Met Asp Lys Ala Gly Gly Tyr 
145                 150                 155                 160 


Gly Ile Gln Ala Leu Gly Gly Met Leu Val Glu Ser Val His Gly Asp 
                165                 170                 175     


Phe Leu Asn Val Val Gly Phe Pro Leu Asn His Phe Cys Lys Gln Leu 
            180                 185                 190         


Val Lys Leu Tyr Tyr Pro Pro Arg Pro Glu Asp Leu Arg Arg Ser Val 
        195                 200                 205             


Lys His Asp Ser Ile Pro Ala Ala Asp Thr Phe Glu Asp Leu Ser Asp 
    210                 215                 220                 


Val Glu Gly Gly Gly Ser Glu Pro Thr Gln Arg Asp Ala Gly Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ala Glu Ala Gly Glu Ala Gly Gln Ala Thr Ala Glu Ala 
                245                 250                 255     


Glu Cys His Arg Thr Arg Glu Thr Leu Pro Pro Phe Pro Thr Arg Leu 
            260                 265                 270         


Leu Glu Leu Ile Glu Gly Phe Met Leu Ser Lys Gly Leu Leu Thr Ala 
        275                 280                 285             


Cys Lys Leu Lys Val Phe Asp Leu Leu Lys Asp Glu Ala Pro Gln Lys 
    290                 295                 300                 


Ala Ala Asp Ile Ala Ser Lys Val Asp Ala Ser Ala Cys Gly Met Glu 
305                 310                 315                 320 


Arg Leu Leu Asp Ile Cys Ala Ala Met Gly Leu Leu Glu Lys Thr Glu 
                325                 330                 335     


Gln Gly Tyr Ser Asn Thr Glu Thr Ala Asn Val Tyr Leu Ala Ser Asp 
            340                 345                 350         


Gly Glu Tyr Ser Leu His Gly Phe Ile Met His Asn Asn Asp Leu Thr 
        355                 360                 365             


Trp Asn Leu Phe Thr Tyr Leu Glu Phe Ala Ile Arg Glu Gly Thr Asn 
    370                 375                 380                 


Gln His His Arg Ala Leu Gly Lys Lys Ala Glu Asp Leu Phe Gln Asp 
385                 390                 395                 400 


Ala Tyr Tyr Gln Ser Pro Glu Thr Arg Leu Arg Phe Met Arg Ala Met 
                405                 410                 415     


His Gly Met Thr Lys Leu Thr Ala Cys Gln Val Ala Thr Ala Phe Asn 
            420                 425                 430         


Leu Ser Arg Phe Ser Ser Ala Cys Asp Val Gly Gly Cys Thr Gly Ala 
        435                 440                 445             


Leu Ala Arg Glu Leu Ala Arg Glu Tyr Pro Arg Met Gln Val Thr Val 
    450                 455                 460                 


Phe Asp Leu Pro Asp Ile Ile Glu Leu Ala Ala His Phe Gln Pro Pro 
465                 470                 475                 480 


Gly Pro Gln Ala Val Gln Ile His Phe Ala Ala Gly Asp Phe Phe Arg 
                485                 490                 495     


Asp Pro Leu Pro Ser Ala Glu Leu Tyr Val Leu Cys Arg Ile Leu His 
            500                 505                 510         


Asp Trp Pro Asp Asp Lys Val His Lys Leu Leu Ser Arg Val Ala Glu 
        515                 520                 525             


Ser Cys Lys Pro Gly Ala Gly Leu Leu Leu Val Glu Thr Leu Leu Asp 
    530                 535                 540                 


Glu Glu Lys Arg Val Ala Gln Arg Ala Leu Met Gln Ser Leu Asn Met 
545                 550                 555                 560 


Leu Val Gln Thr Glu Gly Lys Glu Arg Ser Leu Gly Glu Tyr Gln Cys 
                565                 570                 575     


Leu Leu Glu Leu His Gly Phe His Gln Val Gln Val Val His Leu Gly 
            580                 585                 590         


Gly Val Leu Asp Ala Ile Leu Ala Thr Lys Val Ala Pro 
        595                 600                 605 


<210>  852
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASNA1__Homo_sapiens__NP_004308

<400>  852

Met Ala Ala Gly Val Ala Gly Trp Gly Val Glu Ala Glu Glu Phe Glu 
1               5                   10                  15      


Asp Ala Pro Asp Val Glu Pro Leu Glu Pro Thr Leu Ser Asn Ile Ile 
            20                  25                  30          


Glu Gln Arg Ser Leu Lys Trp Ile Phe Val Gly Gly Lys Gly Gly Val 
        35                  40                  45              


Gly Lys Thr Thr Cys Ser Cys Ser Leu Ala Val Gln Leu Ser Lys Gly 
    50                  55                  60                  


Arg Glu Ser Val Leu Ile Ile Ser Thr Asp Pro Ala His Asn Ile Ser 
65                  70                  75                  80  


Asp Ala Phe Asp Gln Lys Phe Ser Lys Val Pro Thr Lys Val Lys Gly 
                85                  90                  95      


Tyr Asp Asn Leu Phe Ala Met Glu Ile Asp Pro Ser Leu Gly Val Ala 
            100                 105                 110         


Glu Leu Pro Asp Glu Phe Phe Glu Glu Asp Asn Met Leu Ser Met Gly 
        115                 120                 125             


Lys Lys Met Met Gln Glu Ala Met Ser Ala Phe Pro Gly Ile Asp Glu 
    130                 135                 140                 


Ala Met Ser Tyr Ala Glu Val Met Arg Leu Val Lys Gly Met Asn Phe 
145                 150                 155                 160 


Ser Val Val Val Phe Asp Thr Ala Pro Thr Gly His Thr Leu Arg Leu 
                165                 170                 175     


Leu Asn Phe Pro Thr Ile Val Glu Arg Gly Leu Gly Arg Leu Met Gln 
            180                 185                 190         


Ile Lys Asn Gln Ile Ser Pro Phe Ile Ser Gln Met Cys Asn Met Leu 
        195                 200                 205             


Gly Leu Gly Asp Met Asn Ala Asp Gln Leu Ala Ser Lys Leu Glu Glu 
    210                 215                 220                 


Thr Leu Pro Val Ile Arg Ser Val Ser Glu Gln Phe Lys Asp Pro Glu 
225                 230                 235                 240 


Gln Thr Thr Phe Ile Cys Val Cys Ile Ala Glu Phe Leu Ser Leu Tyr 
                245                 250                 255     


Glu Thr Glu Arg Leu Ile Gln Glu Leu Ala Lys Cys Lys Ile Asp Thr 
            260                 265                 270         


His Asn Ile Ile Val Asn Gln Leu Val Phe Pro Asp Pro Glu Lys Pro 
        275                 280                 285             


Cys Lys Met Cys Glu Ala Arg His Lys Ile Gln Ala Lys Tyr Leu Asp 
    290                 295                 300                 


Gln Met Glu Asp Leu Tyr Glu Asp Phe His Ile Val Lys Leu Pro Leu 
305                 310                 315                 320 


Leu Pro His Glu Val Arg Gly Ala Asp Lys Val Asn Thr Phe Ser Ala 
                325                 330                 335     


Leu Leu Leu Glu Pro Tyr Lys Pro Pro Ser Ala Gln 
            340                 345             


<210>  853
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASNS__Homo_sapiens__NP_001171546

<400>  853

Met Lys Ile Ala His Arg Gly Pro Asp Ala Phe Arg Phe Glu Asn Val 
1               5                   10                  15      


Asn Gly Tyr Thr Asn Cys Cys Phe Gly Phe His Arg Leu Ala Val Val 
            20                  25                  30          


Asp Pro Leu Phe Gly Met Gln Pro Ile Arg Val Lys Lys Tyr Pro Tyr 
        35                  40                  45              


Leu Trp Leu Cys Tyr Asn Gly Glu Ile Tyr Asn His Lys Lys Met Gln 
    50                  55                  60                  


Gln His Phe Glu Phe Glu Tyr Gln Thr Lys Val Asp Gly Glu Ile Ile 
65                  70                  75                  80  


Leu His Leu Tyr Asp Lys Gly Gly Ile Glu Gln Thr Ile Cys Met Leu 
                85                  90                  95      


Asp Gly Val Phe Ala Phe Val Leu Leu Asp Thr Ala Asn Lys Lys Val 
            100                 105                 110         


Phe Leu Gly Arg Asp Thr Tyr Gly Val Arg Pro Leu Phe Lys Ala Met 
        115                 120                 125             


Thr Glu Asp Gly Phe Leu Ala Val Cys Ser Glu Ala Lys Gly Leu Val 
    130                 135                 140                 


Thr Leu Lys His Ser Ala Thr Pro Phe Leu Lys Val Glu Pro Phe Leu 
145                 150                 155                 160 


Pro Gly His Tyr Glu Val Leu Asp Leu Lys Pro Asn Gly Lys Val Ala 
                165                 170                 175     


Ser Val Glu Met Val Lys Tyr His His Cys Arg Asp Val Pro Leu His 
            180                 185                 190         


Ala Leu Tyr Asp Asn Val Glu Lys Leu Phe Pro Gly Phe Glu Ile Glu 
        195                 200                 205             


Thr Val Lys Asn Asn Leu Arg Ile Leu Phe Asn Asn Ala Val Lys Lys 
    210                 215                 220                 


Arg Leu Met Thr Asp Arg Arg Ile Gly Cys Leu Leu Ser Gly Gly Leu 
225                 230                 235                 240 


Asp Ser Ser Leu Val Ala Ala Thr Leu Leu Lys Gln Leu Lys Glu Ala 
                245                 250                 255     


Gln Val Gln Tyr Pro Leu Gln Thr Phe Ala Ile Gly Met Glu Asp Ser 
            260                 265                 270         


Pro Asp Leu Leu Ala Ala Arg Lys Val Ala Asp His Ile Gly Ser Glu 
        275                 280                 285             


His Tyr Glu Val Leu Phe Asn Ser Glu Glu Gly Ile Gln Ala Leu Asp 
    290                 295                 300                 


Glu Val Ile Phe Ser Leu Glu Thr Tyr Asp Ile Thr Thr Val Arg Ala 
305                 310                 315                 320 


Ser Val Gly Met Tyr Leu Ile Ser Lys Tyr Ile Arg Lys Asn Thr Asp 
                325                 330                 335     


Ser Val Val Ile Phe Ser Gly Glu Gly Ser Asp Glu Leu Thr Gln Gly 
            340                 345                 350         


Tyr Ile Tyr Phe His Lys Ala Pro Ser Pro Glu Lys Ala Glu Glu Glu 
        355                 360                 365             


Ser Glu Arg Leu Leu Arg Glu Leu Tyr Leu Phe Asp Val Leu Arg Ala 
    370                 375                 380                 


Asp Arg Thr Thr Ala Ala His Gly Leu Glu Leu Arg Val Pro Phe Leu 
385                 390                 395                 400 


Asp His Arg Phe Ser Ser Tyr Tyr Leu Ser Leu Pro Pro Glu Met Arg 
                405                 410                 415     


Ile Pro Lys Asn Gly Ile Glu Lys His Leu Leu Arg Glu Thr Phe Glu 
            420                 425                 430         


Asp Ser Asn Leu Ile Pro Lys Glu Ile Leu Trp Arg Pro Lys Glu Ala 
        435                 440                 445             


Phe Ser Asp Gly Ile Thr Ser Val Lys Asn Ser Trp Phe Lys Ile Leu 
    450                 455                 460                 


Gln Glu Tyr Val Glu His Gln Val Asp Asp Ala Met Met Ala Asn Ala 
465                 470                 475                 480 


Ala Gln Lys Phe Pro Phe Asn Thr Pro Lys Thr Lys Glu Gly Tyr Tyr 
                485                 490                 495     


Tyr Arg Gln Val Phe Glu Arg His Tyr Pro Gly Arg Ala Asp Trp Leu 
            500                 505                 510         


Ser His Tyr Trp Met Pro Lys Trp Ile Asn Ala Thr Asp Pro Ser Ala 
        515                 520                 525             


Arg Thr Leu Thr His Tyr Lys Ser Ala Val Lys Ala 
    530                 535                 540 


<210>  854
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPA__Homo_sapiens__XP_006721590

<400>  854

Met Thr Ser Cys His Ile Ala Glu Glu His Ile Gln Lys Val Ala Ile 
1               5                   10                  15      


Phe Gly Gly Thr His Gly Asn Glu Leu Thr Gly Val Phe Leu Val Lys 
            20                  25                  30          


His Trp Leu Glu Asn Gly Ala Glu Ile Gln Arg Thr Gly Leu Glu Val 
        35                  40                  45              


Lys Pro Phe Ile Thr Asn Pro Arg Ala Val Lys Lys Cys Thr Arg Tyr 
    50                  55                  60                  


Ile Asp Cys Asp Leu Asn Arg Ile Phe Asp Leu Glu Asn Leu Gly Lys 
65                  70                  75                  80  


Lys Met Ser Glu Asp Leu Pro Tyr Glu Val Arg Arg Ala Gln Glu Ile 
                85                  90                  95      


Asn His Leu Phe Gly Pro Lys Asp Ser Glu Asp Ser Tyr Asp Ile Ile 
            100                 105                 110         


Phe Asp Leu His Asn Thr Thr Ser Asn Met Gly Cys Thr Leu Ile Leu 
        115                 120                 125             


Glu Asp Ser Arg Asn Asn Phe Leu Ile Gln Met Phe His Tyr Ile Lys 
    130                 135                 140                 


Thr Ser Leu Ala Pro Leu Pro Cys Tyr Val Tyr Leu Ile Glu His Pro 
145                 150                 155                 160 


Ser Leu Lys Tyr Ala Thr Thr Arg Ser Ile Ala Lys Tyr Pro Val Gly 
                165                 170                 175     


Ile Glu Val Gly Pro Gln Pro Gln Gly Val Leu Arg Ala Asp Ile Leu 
            180                 185                 190         


Asp Gln Met Arg Lys Met Ile Lys His Ala Leu Asp Phe Ile His His 
        195                 200                 205             


Phe Asn Glu Gly Lys Glu Phe Pro Pro Cys Ala Ile Glu Val Tyr Lys 
    210                 215                 220                 


Ile Ile Glu Lys Val Asp Tyr Pro Arg Asp Glu Asn Gly Glu Ile Ala 
225                 230                 235                 240 


Ala Ile Ile His Pro Asn Leu Gln Asp Gln Asp Trp Lys Pro Leu His 
                245                 250                 255     


Pro Gly Asp Pro Met Phe Leu Thr Leu Asp Gly Lys Thr Ile Pro Leu 
            260                 265                 270         


Gly Gly Asp Cys Thr Val Tyr Pro Val Phe Val Asn Glu Ala Ala Tyr 
        275                 280                 285             


Tyr Glu Lys Lys Glu Ala Phe Ala Lys Thr Thr Lys Leu Thr Leu Asn 
    290                 295                 300                 


Ala Lys Ser Ile Arg Cys Cys Leu His 
305                 310             


<210>  855
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPG__Homo_sapiens__NP_001073933

<400>  855

Met Ala Arg Ala Val Gly Pro Glu Arg Arg Leu Leu Ala Val Tyr Thr 
1               5                   10                  15      


Gly Gly Thr Ile Gly Met Arg Ser Glu Leu Gly Val Leu Val Pro Gly 
            20                  25                  30          


Thr Gly Leu Ala Ala Ile Leu Arg Thr Leu Pro Met Phe His Asp Glu 
        35                  40                  45              


Glu His Ala Arg Ala Arg Gly Leu Ser Glu Asp Thr Leu Val Leu Pro 
    50                  55                  60                  


Pro Ala Ser Arg Asn Gln Arg Ile Leu Tyr Thr Val Leu Glu Cys Gln 
65                  70                  75                  80  


Pro Leu Phe Asp Ser Ser Asp Met Thr Ile Ala Glu Trp Val Cys Leu 
                85                  90                  95      


Ala Gln Thr Ile Lys Arg His Tyr Glu Gln Tyr His Gly Phe Val Val 
            100                 105                 110         


Ile His Gly Thr Asp Thr Met Ala Phe Ala Ala Ser Met Leu Ser Phe 
        115                 120                 125             


Met Leu Glu Asn Leu Gln Lys Thr Val Ile Leu Thr Gly Ala Gln Val 
    130                 135                 140                 


Pro Ile His Ala Leu Trp Ser Asp Gly Arg Glu Asn Leu Leu Gly Ala 
145                 150                 155                 160 


Leu Leu Met Ala Gly Gln Tyr Val Ile Pro Glu Val Cys Leu Phe Phe 
                165                 170                 175     


Gln Asn Gln Leu Phe Arg Gly Asn Arg Ala Thr Lys Val Asp Ala Arg 
            180                 185                 190         


Arg Phe Ala Ala Phe Cys Ser Pro Asn Leu Leu Pro Leu Ala Thr Val 
        195                 200                 205             


Gly Ala Asp Ile Thr Ile Asn Arg Glu Leu Val Arg Lys Val Asp Gly 
    210                 215                 220                 


Lys Ala Gly Leu Val Val His Ser Ser Met Glu Gln Asp Val Gly Leu 
225                 230                 235                 240 


Leu Arg Leu Tyr Pro Gly Ile Pro Ala Ala Leu Val Arg Ala Phe Leu 
                245                 250                 255     


Gln Pro Pro Leu Lys Gly Val Val Met Glu Thr Phe Gly Ser Gly Asn 
            260                 265                 270         


Gly Pro Thr Lys Pro Asp Leu Leu Gln Glu Leu Arg Val Ala Thr Glu 
        275                 280                 285             


Arg Gly Leu Val Ile Val Asn Cys Thr His Cys Leu Gln Gly Ala Val 
    290                 295                 300                 


Thr Thr Asp Tyr Ala Ala Gly Met Ala Met Ala Gly Ala Gly Val Ile 
305                 310                 315                 320 


Ser Gly Phe Asp Met Thr Ser Glu Ala Ala Leu Ala Lys Leu Ser Tyr 
                325                 330                 335     


Val Leu Gly Gln Pro Gly Leu Ser Leu Asp Val Arg Lys Glu Leu Leu 
            340                 345                 350         


Thr Lys Asp Leu Arg Gly Glu Met Thr Pro Pro Ser Val Glu Glu Arg 
        355                 360                 365             


Arg Pro Ser Leu Gln Gly Asn Thr Leu Gly Gly Gly Val Ser Trp Leu 
    370                 375                 380                 


Leu Ser Leu Ser Gly Ser Gln Glu Ala Asp Ala Leu Arg Asn Ala Leu 
385                 390                 395                 400 


Val Pro Ser Leu Ala Cys Ala Ala Ala His Ala Gly Asp Val Glu Ala 
                405                 410                 415     


Leu Gln Ala Leu Val Glu Leu Gly Ser Asp Leu Gly Leu Val Asp Phe 
            420                 425                 430         


Asn Gly Gln Thr Pro Leu His Ala Ala Ala Arg Gly Gly His Thr Glu 
        435                 440                 445             


Ala Val Thr Met Leu Leu Gln Arg Gly Val Asp Val Asn Thr Arg Asp 
    450                 455                 460                 


Thr Asp Gly Phe Ser Pro Leu Leu Leu Ala Val Arg Gly Arg His Pro 
465                 470                 475                 480 


Gly Val Ile Gly Leu Leu Arg Glu Ala Gly Ala Ser Leu Ser Thr Gln 
                485                 490                 495     


Glu Leu Glu Glu Ala Gly Thr Glu Leu Cys Arg Leu Ala Tyr Arg Ala 
            500                 505                 510         


Asp Leu Glu Gly Leu Gln Val Trp Trp Gln Ala Gly Ala Asp Leu Gly 
        515                 520                 525             


Gln Pro Gly Tyr Asp Gly His Ser Ala Leu His Val Ala Glu Ala Ala 
    530                 535                 540                 


Gly Asn Leu Ala Val Val Ala Phe Leu Gln Ser Leu Glu Gly Ala Val 
545                 550                 555                 560 


Gly Ala Gln Ala Pro Cys Pro Glu Val Leu Pro Gly Val 
                565                 570             


<210>  856
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH__Homo_sapiens__NP_001158222

<400>  856

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp 
    50                  55                  60                  


Gly Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu 
65                  70                  75                  80  


Lys Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu 
                85                  90                  95      


Pro His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln 
            100                 105                 110         


Asn Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu 
        115                 120                 125             


Met Val His Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp 
    130                 135                 140                 


Gly Pro Thr Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala 
145                 150                 155                 160 


Thr Asp Val Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His 
                165                 170                 175     


Glu Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp 
            180                 185                 190         


Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp 
        195                 200                 205             


Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp 
    210                 215                 220                 


Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu 
225                 230                 235                 240 


Glu Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp 
                245                 250                 255     


Asn Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe 
            260                 265                 270         


Pro Val Glu Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr 
        275                 280                 285             


Asp Asp Pro Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu 
    290                 295                 300                 


Leu Asn Lys Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys 
                325                 330                 335     


Glu Leu Val Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys 
            340                 345                 350         


Ala Gln Cys Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val 
        355                 360                 365             


Leu Arg Gly Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp 
    370                 375                 380                 


Val Pro Ala Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg 
385                 390                 395                 400 


Gln Gln Phe Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg 
                405                 410                 415     


Leu Val Gln Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly 
            420                 425                 430         


Val Gly Tyr Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr 
        435                 440                 445             


Glu Glu Val Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His 
    450                 455                 460                 


Tyr Gly Phe Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro 
465                 470                 475                 480 


Tyr Leu Lys Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly 
                485                 490                 495     


Arg Phe Tyr Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys 
            500                 505                 510         


Glu Ala Tyr Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala 
        515                 520                 525             


Ser Val Trp Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln 
    530                 535                 540                 


Pro Trp Trp Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser 
545                 550                 555                 560 


Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met 
                565                 570                 575     


Asp Lys Ala Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu 
            580                 585                 590         


Lys Gly Asp Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn 
        595                 600                 605             


Glu Asn Ala Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys 
    610                 615                 620                 


Phe Pro Glu Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile 
625                 630                 635                 640 


Met His Pro Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys 
                645                 650                 655     


Arg Leu Arg Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys 
            660                 665                 670         


Ile Arg Cys Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu 
        675                 680                 685             


Ile Phe Asp Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser 
    690                 695                 700                 


Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro 
705                 710                 715                 720 


Gln Gln Arg Arg Ser Leu Pro Ala Ile 
                725                 


<210>  857
<211>  1892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPM__Homo_sapiens__NP_001193775

<400>  857

Met Ala Asn Arg Arg Val Gly Arg Gly Cys Trp Glu Val Ser Pro Thr 
1               5                   10                  15      


Glu Arg Arg Pro Pro Ala Gly Leu Arg Gly Pro Ala Ala Glu Glu Glu 
            20                  25                  30          


Ala Ser Ser Pro Pro Val Leu Ser Leu Ser His Phe Cys Arg Ser Pro 
        35                  40                  45              


Phe Leu Cys Phe Gly Asp Val Leu Leu Gly Ala Ser Arg Thr Leu Ser 
    50                  55                  60                  


Leu Ala Leu Asp Asn Pro Asn Glu Glu Val Ala Glu Val Lys Ile Ser 
65                  70                  75                  80  


His Phe Pro Ala Ala Asp Leu Gly Phe Ser Val Ser Gln Arg Cys Phe 
                85                  90                  95      


Val Leu Gln Pro Lys Glu Lys Ile Val Ile Ser Val Asn Trp Thr Pro 
            100                 105                 110         


Leu Lys Glu Gly Arg Val Arg Glu Ile Met Thr Phe Leu Val Asn Asp 
        115                 120                 125             


Val Leu Lys His Gln Ala Ile Leu Leu Gly Asn Ala Glu Glu Gln Lys 
    130                 135                 140                 


Lys Lys Lys Arg Ser Leu Trp Asp Thr Ile Lys Lys Lys Lys Ile Ser 
145                 150                 155                 160 


Ala Ser Thr Ser His Asn Arg Arg Val Ser Asn Ile Gln Asn Val Asn 
                165                 170                 175     


Lys Thr Phe Ser Val Ser Gln Lys Val Asp Arg Val Arg Ser Pro Leu 
            180                 185                 190         


Gln Ala Cys Glu Asn Leu Ala Met Asn Glu Gly Gly Pro Pro Thr Glu 
        195                 200                 205             


Asn Asn Ser Leu Ile Leu Glu Glu Asn Lys Ile Pro Ile Ser Pro Ile 
    210                 215                 220                 


Ser Pro Ala Phe Asn Glu Cys His Gly Ala Thr Cys Leu Pro Leu Ser 
225                 230                 235                 240 


Val Arg Arg Ser Thr Thr Tyr Ser Ser Leu His Ala Ser Glu Asn Arg 
                245                 250                 255     


Glu Leu Leu Asn Val His Ser Ala Asn Val Ser Lys Val Ser Phe Asn 
            260                 265                 270         


Glu Lys Ala Val Thr Glu Thr Ser Phe Asn Ser Val Asn Val Asn Gly 
        275                 280                 285             


Gln Arg Gly Glu Asn Ser Lys Leu Ser Leu Thr Pro Asn Cys Ser Ser 
    290                 295                 300                 


Thr Leu Asn Ile Thr Gln Ser Gln Ile His Phe Leu Ser Pro Asp Ser 
305                 310                 315                 320 


Phe Val Asn Asn Ser His Gly Ala Asn Asn Glu Leu Glu Leu Val Thr 
                325                 330                 335     


Cys Leu Ser Ser Asp Met Phe Met Lys Asp Asn Ser Gln Pro Val His 
            340                 345                 350         


Leu Glu Ser Thr Ile Ala His Glu Ile Tyr Gln Lys Ile Leu Ser Pro 
        355                 360                 365             


Asp Ser Phe Ile Lys Asp Asn Tyr Gly Leu Asn Gln Asp Leu Glu Ser 
    370                 375                 380                 


Glu Ser Val Asn Pro Ile Leu Ser Pro Asn Gln Phe Leu Lys Asp Asn 
385                 390                 395                 400 


Met Ala Tyr Met Cys Thr Ser Gln Gln Thr Cys Lys Val Pro Leu Ser 
                405                 410                 415     


Asn Glu Asn Ser Gln Val Pro Gln Ser Pro Glu Asp Trp Arg Lys Ser 
            420                 425                 430         


Glu Val Ser Pro Arg Ile Pro Glu Cys Gln Gly Ser Lys Ser Pro Lys 
        435                 440                 445             


Ala Ile Phe Glu Glu Leu Val Glu Met Lys Ser Asn Tyr Tyr Ser Phe 
    450                 455                 460                 


Ile Lys Gln Asn Asn Pro Lys Phe Ser Ala Val Gln Asp Ile Ser Ser 
465                 470                 475                 480 


His Ser His Asn Lys Gln Pro Lys Arg Arg Pro Ile Leu Ser Ala Thr 
                485                 490                 495     


Val Thr Lys Arg Lys Ala Thr Cys Thr Arg Glu Asn Gln Thr Glu Ile 
            500                 505                 510         


Asn Lys Pro Lys Ala Lys Arg Cys Leu Asn Ser Ala Val Gly Glu His 
        515                 520                 525             


Glu Lys Val Ile Asn Asn Gln Lys Glu Lys Glu Asp Phe His Ser Tyr 
    530                 535                 540                 


Leu Pro Ile Ile Asp Pro Ile Leu Ser Lys Ser Lys Ser Tyr Lys Asn 
545                 550                 555                 560 


Glu Val Thr Pro Ser Ser Thr Thr Ala Ser Val Ala Arg Lys Arg Lys 
                565                 570                 575     


Ser Asp Gly Ser Met Glu Asp Ala Asn Val Arg Val Ala Ile Thr Glu 
            580                 585                 590         


His Thr Glu Val Arg Glu Ile Lys Arg Ile His Phe Ser Pro Ser Glu 
        595                 600                 605             


Pro Lys Thr Ser Ala Val Lys Lys Thr Lys Asn Val Thr Thr Pro Ile 
    610                 615                 620                 


Ser Lys Arg Ile Ser Asn Arg Glu Lys Leu Asn Leu Lys Lys Lys Thr 
625                 630                 635                 640 


Asp Leu Ser Ile Phe Arg Thr Pro Ile Ser Lys Thr Asn Lys Arg Thr 
                645                 650                 655     


Lys Pro Ile Ile Ala Val Ala Gln Ser Ser Leu Thr Phe Ile Lys Pro 
            660                 665                 670         


Leu Lys Thr Asp Ile Pro Arg His Pro Met Pro Phe Ala Ala Lys Asn 
        675                 680                 685             


Met Phe Tyr Asp Glu Arg Trp Lys Glu Lys Gln Glu Gln Gly Phe Thr 
    690                 695                 700                 


Trp Trp Leu Asn Phe Ile Leu Thr Pro Asp Asp Phe Thr Val Lys Thr 
705                 710                 715                 720 


Asn Ile Ser Glu Val Asn Ala Ala Thr Leu Leu Leu Gly Ile Glu Asn 
                725                 730                 735     


Gln His Lys Ile Ser Val Pro Arg Ala Pro Thr Lys Glu Glu Met Ser 
            740                 745                 750         


Leu Arg Ala Tyr Thr Ala Arg Cys Arg Leu Asn Arg Leu Arg Arg Ala 
        755                 760                 765             


Ala Cys Arg Leu Phe Thr Ser Glu Lys Met Val Lys Ala Ile Lys Lys 
    770                 775                 780                 


Leu Glu Ile Glu Ile Glu Ala Arg Arg Leu Ile Val Arg Lys Asp Arg 
785                 790                 795                 800 


His Leu Trp Lys Asp Val Gly Glu Arg Gln Lys Val Leu Asn Trp Leu 
                805                 810                 815     


Leu Ser Tyr Asn Pro Leu Trp Leu Arg Ile Gly Leu Glu Thr Thr Tyr 
            820                 825                 830         


Gly Glu Leu Ile Ser Leu Glu Asp Asn Ser Asp Val Thr Gly Leu Ala 
        835                 840                 845             


Met Phe Ile Leu Asn Arg Leu Leu Trp Asn Pro Asp Ile Ala Ala Glu 
    850                 855                 860                 


Tyr Arg His Pro Thr Val Pro His Leu Tyr Arg Asp Gly His Glu Glu 
865                 870                 875                 880 


Ala Leu Ser Lys Phe Thr Leu Lys Lys Leu Leu Leu Leu Val Cys Phe 
                885                 890                 895     


Leu Asp Tyr Ala Lys Ile Ser Arg Leu Ile Asp His Asp Pro Cys Leu 
            900                 905                 910         


Phe Cys Lys Asp Ala Glu Phe Lys Ala Ser Lys Glu Ile Leu Leu Ala 
        915                 920                 925             


Phe Ser Arg Asp Phe Leu Ser Gly Glu Gly Asp Leu Ser Arg His Leu 
    930                 935                 940                 


Gly Leu Leu Gly Leu Pro Val Asn His Val Gln Thr Pro Phe Asp Glu 
945                 950                 955                 960 


Phe Asp Phe Ala Val Thr Asn Leu Ala Val Asp Leu Gln Cys Gly Val 
                965                 970                 975     


Arg Leu Val Arg Thr Met Glu Leu Leu Thr Gln Asn Trp Asp Leu Ser 
            980                 985                 990         


Lys Lys Leu Arg Ile Pro Ala Ile  Ser Arg Leu Gln Lys  Met His Asn 
        995                 1000                 1005             


Val Asp  Ile Val Leu Gln Val  Leu Lys Ser Arg Gly  Ile Glu Leu 
    1010                 1015                 1020             


Ser Asp  Glu His Gly Asn Thr  Ile Leu Ser Lys Asp  Ile Val Asp 
    1025                 1030                 1035             


Arg His  Arg Glu Lys Thr Leu  Arg Leu Leu Trp Lys  Ile Ala Phe 
    1040                 1045                 1050             


Ala Phe  Gln Val Asp Ile Ser  Leu Asn Leu Asp Gln  Leu Lys Glu 
    1055                 1060                 1065             


Glu Ile  Ala Phe Leu Lys His  Thr Lys Ser Ile Lys  Lys Thr Ile 
    1070                 1075                 1080             


Ser Leu  Leu Ser Cys His Ser  Asp Asp Leu Ile Asn  Lys Lys Lys 
    1085                 1090                 1095             


Gly Lys  Arg Asp Ser Gly Ser  Phe Glu Gln Tyr Ser  Glu Asn Ile 
    1100                 1105                 1110             


Lys Leu  Leu Met Asp Trp Val  Asn Ala Val Cys Ala  Phe Tyr Asn 
    1115                 1120                 1125             


Lys Lys  Val Glu Asn Phe Thr  Val Ser Phe Ser Asp  Gly Arg Val 
    1130                 1135                 1140             


Leu Cys  Tyr Leu Ile His His  Tyr His Pro Cys Tyr  Val Pro Phe 
    1145                 1150                 1155             


Asp Ala  Ile Cys Gln Arg Thr  Thr Gln Thr Val Glu  Cys Thr Gln 
    1160                 1165                 1170             


Thr Gly  Ser Val Val Leu Asn  Ser Ser Ser Glu Ser  Asp Asp Ser 
    1175                 1180                 1185             


Ser Leu  Asp Met Ser Leu Lys  Ala Phe Asp His Glu  Asn Thr Ser 
    1190                 1195                 1200             


Glu Leu  Tyr Lys Glu Leu Leu  Glu Asn Glu Lys Lys  Asn Phe His 
    1205                 1210                 1215             


Leu Val  Arg Ser Ala Val Arg  Asp Leu Gly Gly Ile  Pro Ala Met 
    1220                 1225                 1230             


Ile Asn  His Ser Asp Met Ser  Asn Thr Ile Pro Asp  Glu Lys Val 
    1235                 1240                 1245             


Val Ile  Thr Tyr Leu Ser Phe  Leu Cys Ala Arg Leu  Leu Asp Leu 
    1250                 1255                 1260             


Arg Lys  Glu Ile Arg Ala Ala  Arg Leu Ile Gln Thr  Thr Trp Arg 
    1265                 1270                 1275             


Lys Tyr  Lys Leu Lys Thr Asp  Leu Lys Arg His Gln  Glu Arg Glu 
    1280                 1285                 1290             


Lys Ala  Ala Arg Ile Ile Gln  Leu Ala Val Ile Asn  Phe Leu Ala 
    1295                 1300                 1305             


Lys Gln  Arg Leu Arg Lys Arg  Val Asn Ala Ala Leu  Val Ile Gln 
    1310                 1315                 1320             


Lys Tyr  Trp Arg Arg Val Leu  Ala Gln Arg Lys Leu  Leu Met Leu 
    1325                 1330                 1335             


Lys Lys  Glu Lys Leu Glu Lys  Val Gln Asn Lys Ala  Ala Ser Leu 
    1340                 1345                 1350             


Ile Gln  Ala Met Trp Arg Arg  Tyr Arg Ala Lys Lys  Tyr Leu Cys 
    1355                 1360                 1365             


Lys Val  Lys Ala Ala Cys Lys  Ile Gln Ala Trp Tyr  Arg Cys Trp 
    1370                 1375                 1380             


Arg Ala  His Lys Glu Tyr Leu  Ala Ile Leu Lys Ala  Val Lys Ile 
    1385                 1390                 1395             


Ile Gln  Gly Cys Phe Tyr Thr  Lys Leu Glu Arg Thr  Arg Phe Leu 
    1400                 1405                 1410             


Asn Val  Arg Ala Ser Ala Ile  Ile Ile Gln Arg Lys  Trp Arg Ala 
    1415                 1420                 1425             


Ile Leu  Pro Ala Lys Ile Ala  His Glu His Phe Leu  Met Ile Lys 
    1430                 1435                 1440             


Arg His  Arg Ala Ala Cys Leu  Ile Gln Ala His Tyr  Arg Gly Tyr 
    1445                 1450                 1455             


Lys Gly  Arg Gln Val Phe Leu  Arg Gln Lys Ser Ala  Ala Leu Ile 
    1460                 1465                 1470             


Ile Gln  Lys Tyr Ile Arg Ala  Arg Glu Ala Gly Lys  His Glu Arg 
    1475                 1480                 1485             


Ile Lys  Tyr Ile Glu Phe Lys  Lys Ser Thr Val Ile  Leu Gln Ala 
    1490                 1495                 1500             


Leu Val  Arg Gly Trp Leu Val  Arg Lys Arg Phe Leu  Glu Gln Arg 
    1505                 1510                 1515             


Ala Lys  Ile Arg Leu Leu His  Phe Thr Ala Ala Ala  Tyr Tyr His 
    1520                 1525                 1530             


Leu Asn  Ala Val Arg Ile Gln  Arg Ala Tyr Lys Leu  Tyr Leu Ala 
    1535                 1540                 1545             


Val Lys  Asn Ala Asn Lys Gln  Val Asn Ser Val Ile  Cys Ile Gln 
    1550                 1555                 1560             


Arg Trp  Phe Arg Ala Arg Leu  Gln Glu Lys Arg Phe  Ile Gln Lys 
    1565                 1570                 1575             


Tyr His  Ser Ile Lys Lys Ile  Glu His Glu Gly Gln  Glu Cys Leu 
    1580                 1585                 1590             


Ser Gln  Arg Asn Arg Ala Ala  Ser Val Ile Gln Lys  Ala Val Arg 
    1595                 1600                 1605             


His Phe  Leu Leu Arg Lys Lys  Gln Glu Lys Phe Thr  Ser Gly Ile 
    1610                 1615                 1620             


Ile Lys  Ile Gln Ala Leu Trp  Arg Gly Tyr Ser Trp  Arg Lys Lys 
    1625                 1630                 1635             


Asn Asp  Cys Thr Lys Ile Lys  Ala Ile Arg Leu Ser  Leu Gln Val 
    1640                 1645                 1650             


Val Asn  Arg Glu Ile Arg Glu  Glu Asn Lys Leu Tyr  Lys Arg Thr 
    1655                 1660                 1665             


Ala Leu  Ala Leu His Tyr Leu  Leu Thr Tyr Lys His  Leu Ser Ala 
    1670                 1675                 1680             


Ile Leu  Glu Ala Leu Lys His  Leu Glu Val Val Thr  Arg Leu Ser 
    1685                 1690                 1695             


Pro Leu  Cys Cys Glu Asn Met  Ala Gln Ser Gly Ala  Ile Ser Lys 
    1700                 1705                 1710             


Ile Phe  Val Leu Ile Arg Ser  Cys Asn Arg Ser Ile  Pro Cys Met 
    1715                 1720                 1725             


Glu Val  Ile Arg Tyr Ala Val  Gln Val Leu Leu Asn  Val Ser Lys 
    1730                 1735                 1740             


Tyr Glu  Lys Thr Thr Ser Ala  Val Tyr Asp Val Glu  Asn Cys Ile 
    1745                 1750                 1755             


Asp Ile  Leu Leu Glu Leu Leu  Gln Ile Tyr Arg Glu  Lys Pro Gly 
    1760                 1765                 1770             


Asn Lys  Val Ala Asp Lys Gly  Gly Ser Ile Phe Thr  Lys Thr Cys 
    1775                 1780                 1785             


Cys Leu  Leu Ala Ile Leu Leu  Lys Thr Thr Asn Arg  Ala Ser Asp 
    1790                 1795                 1800             


Val Arg  Ser Arg Ser Lys Val  Val Asp Arg Ile Tyr  Ser Leu Tyr 
    1805                 1810                 1815             


Lys Leu  Thr Ala His Lys His  Lys Met Asn Thr Glu  Arg Ile Leu 
    1820                 1825                 1830             


Tyr Lys  Gln Lys Lys Asn Ser  Ser Ile Ser Ile Pro  Phe Ile Pro 
    1835                 1840                 1845             


Glu Thr  Pro Val Arg Thr Arg  Ile Val Ser Arg Leu  Lys Pro Asp 
    1850                 1855                 1860             


Trp Val  Leu Arg Arg Asp Asn  Met Glu Glu Ile Thr  Asn Pro Leu 
    1865                 1870                 1875             


Gln Ala  Ile Gln Met Val Met  Asp Thr Leu Gly Ile  Pro Tyr 
    1880                 1885                 1890         


<210>  858
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPN__Homo_sapiens__NP_001180264

<400>  858

Met Lys Glu Tyr Val Leu Leu Leu Phe Leu Ala Leu Cys Ser Ala Lys 
1               5                   10                  15      


Pro Phe Phe Ser Pro Ser His Ile Ala Leu Lys Asn Met Met Leu Lys 
            20                  25                  30          


Asp Met Glu Asp Thr Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
        35                  40                  45              


Asp Asp Glu Asp Asn Ser Leu Phe Pro Thr Arg Glu Pro Arg Ser His 
    50                  55                  60                  


Phe Phe Pro Phe Asp Leu Phe Pro Met Cys Pro Phe Gly Cys Gln Cys 
65                  70                  75                  80  


Tyr Ser Arg Val Val His Cys Ser Asp Leu Gly Leu Thr Ser Val Pro 
                85                  90                  95      


Thr Asn Ile Pro Phe Asp Thr Arg Met Leu Asp Leu Gln Asn Asn Lys 
            100                 105                 110         


Ile Lys Glu Ile Lys Glu Asn Asp Phe Lys Gly Leu Thr Ser Leu Tyr 
        115                 120                 125             


Gly Leu Ile Leu Asn Asn Asn Lys Leu Thr Lys Ile His Pro Lys Ala 
    130                 135                 140                 


Phe Leu Thr Thr Lys Lys Leu Arg Arg Leu Tyr Leu Ser His Asn Gln 
145                 150                 155                 160 


Leu Ser Glu Ile Pro Leu Asn Leu Pro Lys Ser Leu Ala Glu Leu Arg 
                165                 170                 175     


Ile His Glu Asn Lys Val Lys Lys Ile Gln Lys Asp Thr Phe Lys Gly 
            180                 185                 190         


Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu Asp Asn 
        195                 200                 205             


Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Thr Val Phe His Ile 
    210                 215                 220                 


Arg Ile Ala Glu Ala Lys Leu Thr Ser Val Pro Lys Asp Asn Leu Pro 
225                 230                 235                 240 


Ser Phe 
        


<210>  859
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPRV1__Homo_sapiens__NP_690005

<400>  859

Met Gly Ser Pro Gly Ala Ser Leu Gly Ile Lys Lys Ala Leu Gln Ser 
1               5                   10                  15      


Glu Gln Ala Thr Ala Leu Pro Ala Ser Ala Pro Ala Val Ser Gln Pro 
            20                  25                  30          


Thr Ala Pro Ala Pro Ser Cys Leu Pro Lys Ala Gly Gln Val Ile Pro 
        35                  40                  45              


Thr Leu Leu Arg Glu Ala Pro Phe Ser Ser Val Ile Ala Pro Thr Leu 
    50                  55                  60                  


Leu Cys Gly Phe Leu Phe Leu Ala Trp Val Ala Ala Glu Val Pro Glu 
65                  70                  75                  80  


Glu Ser Ser Arg Met Ala Gly Ser Gly Ala Arg Ser Glu Glu Gly Arg 
                85                  90                  95      


Arg Gln His Ala Phe Val Pro Glu Pro Phe Asp Gly Ala Asn Val Val 
            100                 105                 110         


Pro Asn Leu Trp Leu His Ser Phe Glu Val Ile Asn Asp Leu Asn His 
        115                 120                 125             


Trp Asp His Ile Thr Lys Leu Arg Phe Leu Lys Glu Ser Leu Arg Gly 
    130                 135                 140                 


Glu Ala Leu Gly Val Tyr Asn Arg Leu Ser Pro Gln Asp Gln Gly Asp 
145                 150                 155                 160 


Tyr Gly Thr Val Lys Glu Ala Leu Leu Lys Ala Phe Gly Val Pro Gly 
                165                 170                 175     


Ala Ala Pro Ser His Leu Pro Lys Glu Ile Val Phe Ala Asn Ser Met 
            180                 185                 190         


Gly Lys Gly Tyr Tyr Leu Lys Gly Lys Ile Gly Lys Val Pro Val Arg 
        195                 200                 205             


Phe Leu Val Asp Ser Gly Ala Gln Val Ser Val Val His Pro Asn Leu 
    210                 215                 220                 


Trp Glu Glu Val Thr Asp Gly Asp Leu Asp Thr Leu Gln Pro Phe Glu 
225                 230                 235                 240 


Asn Val Val Lys Val Ala Asn Gly Ala Glu Met Lys Ile Leu Gly Val 
                245                 250                 255     


Trp Asp Thr Ala Val Ser Leu Gly Lys Leu Lys Leu Lys Ala Gln Phe 
            260                 265                 270         


Leu Val Ala Asn Ala Ser Ala Glu Glu Ala Ile Ile Gly Thr Asp Val 
        275                 280                 285             


Leu Gln Asp His Asn Ala Ile Leu Asp Phe Glu His Arg Thr Cys Thr 
    290                 295                 300                 


Leu Lys Gly Lys Lys Phe Arg Leu Leu Pro Val Gly Gly Ser Leu Glu 
305                 310                 315                 320 


Asp Glu Phe Asp Leu Glu Leu Ile Glu Glu Asp Pro Ser Ser Glu Glu 
                325                 330                 335     


Gly Arg Gln Glu Leu Ser His 
            340             


<210>  860
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPSCR1__Homo_sapiens__NP_001238817

<400>  860

Met Ala Ala Pro Ala Gly Gly Gly Gly Ser Ala Val Ser Val Leu Ala 
1               5                   10                  15      


Pro Asn Gly Arg Arg His Thr Val Lys Val Thr Pro Ser Thr Val Leu 
            20                  25                  30          


Leu Gln Val Leu Glu Asp Thr Cys Arg Arg Gln Asp Phe Asn Pro Cys 
        35                  40                  45              


Glu Tyr Asp Leu Lys Phe Gln Arg Ser Val Leu Asp Leu Ser Leu Gln 
    50                  55                  60                  


Trp Arg Phe Ala Asn Leu Pro Asn Asn Ala Lys Leu Glu Met Val Pro 
65                  70                  75                  80  


Ala Ser Arg Ser Arg Glu Gly Pro Glu Asn Met Val Arg Ile Ala Leu 
                85                  90                  95      


Gln Leu Asp Asp Gly Ser Arg Leu Gln Asp Ser Phe Cys Ser Gly Gln 
            100                 105                 110         


Thr Leu Trp Glu Leu Leu Ser His Phe Pro Gln Ile Arg Glu Cys Leu 
        115                 120                 125             


Gln His Pro Gly Gly Ala Thr Pro Val Cys Val Tyr Thr Arg Asp Glu 
    130                 135                 140                 


Val Thr Gly Glu Ala Ala Leu Arg Gly Thr Thr Leu Gln Ser Leu Gly 
145                 150                 155                 160 


Leu Thr Gly Gly Ser Ala Thr Ile Arg Phe Val Met Lys Cys Tyr Asp 
                165                 170                 175     


Pro Val Gly Lys Thr Pro Gly Ser Leu Gly Ser Ser Ala Ser Ala Gly 
            180                 185                 190         


Gln Ala Ala Ala Ser Ala Pro Leu Pro Leu Glu Ser Gly Glu Leu Ser 
        195                 200                 205             


Arg Gly Asp Leu Ser Arg Pro Glu Asp Ala Asp Thr Ser Gly Pro Cys 
    210                 215                 220                 


Cys Glu His Thr Gln Glu Lys Gln Ser Thr Arg Ala Pro Ala Ala Ala 
225                 230                 235                 240 


Pro Phe Val Pro Phe Ser Gly Gly Gly Gln Arg Leu Gly Gly Pro Pro 
                245                 250                 255     


Gly Pro Thr Arg Pro Leu Thr Ser Ser Ser Ala Lys Leu Pro Lys Ser 
            260                 265                 270         


Leu Ser Ser Pro Gly Gly Pro Ser Lys Pro Lys Lys Ser Lys Ser Gly 
        275                 280                 285             


Gln Asp Pro Gln Gln Glu Gln Glu Gln Glu Arg Glu Arg Asp Pro Gln 
    290                 295                 300                 


Gln Glu Gln Glu Arg Glu Arg Pro Val Asp Arg Glu Pro Val Asp Arg 
305                 310                 315                 320 


Glu Pro Val Val Cys His Pro Asp Leu Glu Glu Arg Leu Gln Ala Trp 
                325                 330                 335     


Pro Ala Glu Leu Pro Asp Glu Phe Phe Glu Leu Thr Val Asp Asp Val 
            340                 345                 350         


Arg Arg Arg Leu Ala Gln Leu Lys Ser Glu Arg Lys Arg Leu Glu Glu 
        355                 360                 365             


Ala Pro Leu Val Thr Lys Ala Phe Arg Glu Ala Gln Ile Lys Glu Lys 
    370                 375                 380                 


Leu Glu Arg Tyr Pro Lys Val Ala Leu Arg Val Leu Phe Pro Asp Arg 
385                 390                 395                 400 


Tyr Val Leu Gln Gly Phe Phe Arg Pro Ser Glu Thr Val Gly Asp Leu 
                405                 410                 415     


Arg Asp Phe Val Arg Ser His Leu Gly Asn Pro Glu Leu Ser Phe Tyr 
            420                 425                 430         


Leu Phe Ile Thr Pro Pro Lys Thr Val Leu Asp Asp His Thr Gln Thr 
        435                 440                 445             


Leu Phe Gln Pro Gln Leu Gly Asp Arg Val Ala Pro Phe Thr Leu Gly 
    450                 455                 460                 


Pro Ser Leu Lys Arg Cys Leu Gly Pro Glu Gln Arg Thr Arg Leu Pro 
465                 470                 475                 480 


Val Val Gly Asp Gly Gly Asp Val Asp Ser Gly Arg Leu Leu Phe Trp 
                485                 490                 495     


Gly Pro Ser Arg Gly Arg Ala Ser Pro Ser Thr Gly Gln Pro Pro Cys 
            500                 505                 510         


His Pro Val Cys Arg Pro Ser Ser Pro Pro Ser Pro Arg Pro Ser Ser 
        515                 520                 525             


Gly Asp Pro Ser Arg Val Lys Ala Gly His Lys His Val Gly Thr Gly 
    530                 535                 540                 


Arg Ala Asn Leu Phe Pro Ala Ala Leu Val His Leu Gly Ala Glu Glu 
545                 550                 555                 560 


Pro Ala Gly Val Tyr Leu Glu Pro Gly Leu Leu Glu His Ala Ile Ser 
                565                 570                 575     


Pro Ser Ala Ala Asp Val Leu Val Ala Arg Tyr Met Ser Arg Ala Ala 
            580                 585                 590         


Gly Ser Pro Ser Pro Leu Pro Ala Pro Asp Pro Ala Pro Lys Ser Glu 
        595                 600                 605             


Pro Ala Ala Glu Glu Gly Ala Leu Val Pro Pro Glu Pro Ile Pro Gly 
    610                 615                 620                 


Thr Ala Gln Pro Val Lys Arg Ser Leu Gly Lys Val Pro Lys Trp Leu 
625                 630                 635                 640 


Lys Leu Pro Ala Ser Lys Arg 
                645         


<210>  861
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASRGL1__Homo_sapiens__NP_001077395

<400>  861

Met Asn Pro Ile Val Val Val His Gly Gly Gly Ala Gly Pro Ile Ser 
1               5                   10                  15      


Lys Asp Arg Lys Glu Arg Val His Gln Gly Met Val Arg Ala Ala Thr 
            20                  25                  30          


Val Gly Tyr Gly Ile Leu Arg Glu Gly Gly Ser Ala Val Asp Ala Val 
        35                  40                  45              


Glu Gly Ala Val Val Ala Leu Glu Asp Asp Pro Glu Phe Asn Ala Gly 
    50                  55                  60                  


Cys Gly Ser Val Leu Asn Thr Asn Gly Glu Val Glu Met Asp Ala Ser 
65                  70                  75                  80  


Ile Met Asp Gly Lys Asp Leu Ser Ala Gly Ala Val Ser Ala Val Gln 
                85                  90                  95      


Cys Ile Ala Asn Pro Ile Lys Leu Ala Arg Leu Val Met Glu Lys Thr 
            100                 105                 110         


Pro His Cys Phe Leu Thr Asp Gln Gly Ala Ala Gln Phe Ala Ala Ala 
        115                 120                 125             


Met Gly Val Pro Glu Ile Pro Gly Glu Lys Leu Val Thr Glu Arg Asn 
    130                 135                 140                 


Lys Lys Arg Leu Glu Lys Glu Lys His Glu Lys Gly Ala Gln Lys Thr 
145                 150                 155                 160 


Asp Cys Gln Lys Asn Leu Gly Thr Val Gly Ala Val Ala Leu Asp Cys 
                165                 170                 175     


Lys Gly Asn Val Ala Tyr Ala Thr Ser Thr Gly Gly Ile Val Asn Lys 
            180                 185                 190         


Met Val Gly Arg Val Gly Asp Ser Pro Cys Leu Gly Ala Gly Gly Tyr 
        195                 200                 205             


Ala Asp Asn Asp Ile Gly Ala Val Ser Thr Thr Gly His Gly Glu Ser 
    210                 215                 220                 


Ile Leu Lys Val Asn Leu Ala Arg Leu Thr Leu Phe His Ile Glu Gln 
225                 230                 235                 240 


Gly Lys Thr Val Glu Glu Ala Ala Asp Leu Ser Leu Gly Tyr Met Lys 
                245                 250                 255     


Ser Arg Val Lys Gly Leu Gly Gly Leu Ile Val Val Ser Lys Thr Gly 
            260                 265                 270         


Asp Trp Val Ala Lys Trp Thr Ser Thr Ser Met Pro Trp Ala Ala Ala 
        275                 280                 285             


Lys Asp Gly Lys Leu His Phe Gly Ile Asp Pro Asp Asp Thr Thr Ile 
    290                 295                 300                 


Thr Asp Leu Pro 
305             


<210>  862
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASS1__Homo_sapiens__XP_005272257

<400>  862

Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
1               5                   10                  15      


Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
            20                  25                  30          


Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
        35                  40                  45              


Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
    50                  55                  60                  


Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
65                  70                  75                  80  


Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
                85                  90                  95      


Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
            100                 105                 110         


Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
        115                 120                 125             


Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro 
    130                 135                 140                 


Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu 
145                 150                 155                 160 


Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys 
                165                 170                 175     


Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala 
            180                 185                 190         


Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr 
        195                 200                 205             


Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu 
    210                 215                 220                 


Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp 
225                 230                 235                 240 


Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu 
                245                 250                 255     


Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg 
            260                 265                 270         


Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr 
        275                 280                 285             


Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg 
    290                 295                 300                 


Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu 
305                 310                 315                 320 


Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His 
                325                 330                 335     


Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser 
            340                 345                 350         


Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser 
        355                 360                 365             


Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu 
    370                 375                 380                 


Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys 
385                 390                 395                 400 


Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys 
                405                 410         


<210>  863
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASTN2__Homo_sapiens__NP_001171663

<400>  863

Met Pro Phe Ile Thr Tyr Leu Ser Gly Leu Leu Thr Ala Gln Met Leu 
1               5                   10                  15      


Ser Asp Asp Gln Leu Ile Ser Gly Val Glu Ile Arg Cys Glu Glu Lys 
            20                  25                  30          


Gly Arg Cys Pro Ser Thr Cys His Leu Cys Arg Arg Pro Gly Lys Glu 
        35                  40                  45              


Gln Leu Ser Pro Thr Pro Val Leu Leu Glu Ile Asn Arg Val Val Pro 
    50                  55                  60                  


Leu Tyr Thr Leu Ile Gln Asp Asn Gly Thr Lys Glu Ala Phe Lys Ser 
65                  70                  75                  80  


Ala Leu Met Ser Ser Tyr Trp Cys Ser Gly Lys Gly Asp Val Ile Asp 
                85                  90                  95      


Asp Trp Cys Arg Cys Asp Leu Ser Ala Phe Asp Ala Asn Gly Leu Pro 
            100                 105                 110         


Asn Cys Ser Pro Leu Leu Gln Pro Val Leu Arg Leu Ser Pro Thr Val 
        115                 120                 125             


Glu Pro Ser Ser Thr Val Val Ser Leu Glu Trp Val Asp Val Gln Pro 
    130                 135                 140                 


Ala Ile Gly Thr Lys Val Ser Asp Tyr Ile Leu Gln His Lys Lys Val 
145                 150                 155                 160 


Asp Glu Tyr Thr Asp Thr Asp Leu Tyr Thr Gly Glu Phe Leu Ser Phe 
                165                 170                 175     


Ala Asp Asp Leu Leu Ser Gly Leu Gly Thr Ser Cys Val Ala Ala Gly 
            180                 185                 190         


Arg Ser His Gly Glu Val Pro Glu Val Ser Ile Tyr Ser Val Ile Phe 
        195                 200                 205             


Lys Cys Leu Glu Pro Asp Gly Leu Tyr Lys Phe Thr Leu Tyr Ala Val 
    210                 215                 220                 


Asp Thr Arg Gly Arg His Ser Glu Leu Ser Thr Val Thr Leu Arg Thr 
225                 230                 235                 240 


Ala Cys Pro Leu Val Asp Asp Asn Lys Ala Glu Glu Ile Ala Asp Lys 
                245                 250                 255     


Ile Tyr Asn Leu Tyr Asn Gly Tyr Thr Ser Gly Lys Glu Gln Gln Met 
            260                 265                 270         


Ala Tyr Asn Thr Leu Met Glu Val Ser Ala Ser Met Leu Phe Arg Val 
        275                 280                 285             


Gln His His Tyr Asn Ser His Tyr Glu Lys Phe Gly Asp Phe Val Trp 
    290                 295                 300                 


Arg Ser Glu Asp Glu Leu Gly Pro Arg Lys Ala His Leu Ile Leu Arg 
305                 310                 315                 320 


Arg Leu Glu Arg Val Ser Ser His Cys Ser Ser Leu Leu Arg Ser Ala 
                325                 330                 335     


Tyr Ile Gln Ser Arg Val Glu Thr Val Pro Tyr Leu Phe Cys Arg Ser 
            340                 345                 350         


Glu Glu Val Arg Pro Ala Gly Met Val Trp Tyr Ser Ile Leu Lys Asp 
        355                 360                 365             


Thr Lys Ile Thr Tyr Ile Ile 
    370                 375 


<210>  864
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASUN__Homo_sapiens__NP_060634

<400>  864

Met Lys Ile Phe Ser Glu Ser His Lys Thr Val Phe Val Val Asp His 
1               5                   10                  15      


Cys Pro Tyr Met Ala Glu Ser Cys Arg Gln His Val Glu Phe Asp Met 
            20                  25                  30          


Leu Val Lys Asn Arg Thr Gln Gly Ile Ile Pro Leu Ala Pro Ile Ser 
        35                  40                  45              


Lys Ser Leu Trp Thr Cys Ser Val Glu Ser Ser Met Glu Tyr Cys Arg 
    50                  55                  60                  


Ile Met Tyr Asp Ile Phe Pro Phe Lys Lys Leu Val Asn Phe Ile Val 
65                  70                  75                  80  


Ser Asp Ser Gly Ala His Val Leu Asn Ser Trp Thr Gln Glu Asp Gln 
                85                  90                  95      


Asn Leu Gln Glu Leu Met Ala Ala Leu Ala Ala Val Gly Pro Pro Asn 
            100                 105                 110         


Pro Arg Ala Asp Pro Glu Cys Cys Ser Ile Leu His Gly Leu Val Ala 
        115                 120                 125             


Ala Val Glu Thr Leu Cys Lys Ile Thr Glu Tyr Gln His Glu Ala Arg 
    130                 135                 140                 


Thr Leu Leu Met Glu Asn Ala Glu Arg Val Gly Asn Arg Gly Arg Ile 
145                 150                 155                 160 


Ile Cys Ile Thr Asn Ala Lys Ser Asp Ser His Val Arg Met Leu Glu 
                165                 170                 175     


Asp Cys Val Gln Glu Thr Ile His Glu His Asn Lys Leu Ala Ala Asn 
            180                 185                 190         


Ser Asp His Leu Met Gln Ile Gln Lys Cys Glu Leu Val Leu Ile His 
        195                 200                 205             


Thr Tyr Pro Val Gly Glu Asp Ser Leu Val Ser Asp Arg Ser Lys Lys 
    210                 215                 220                 


Glu Leu Ser Pro Val Leu Thr Ser Glu Val His Ser Val Arg Ala Gly 
225                 230                 235                 240 


Arg His Leu Ala Thr Lys Leu Asn Ile Leu Val Gln Gln His Phe Asp 
                245                 250                 255     


Leu Ala Ser Thr Thr Ile Thr Asn Ile Pro Met Lys Glu Glu Gln His 
            260                 265                 270         


Ala Asn Thr Ser Ala Asn Tyr Asp Val Glu Leu Leu His His Lys Asp 
        275                 280                 285             


Ala His Val Asp Phe Leu Lys Ser Gly Asp Ser His Leu Gly Gly Gly 
    290                 295                 300                 


Ser Arg Glu Gly Ser Phe Lys Glu Thr Ile Thr Leu Lys Trp Cys Thr 
305                 310                 315                 320 


Pro Arg Thr Asn Asn Ile Glu Leu His Tyr Cys Thr Gly Ala Tyr Arg 
                325                 330                 335     


Ile Ser Pro Val Asp Val Asn Ser Arg Pro Ser Ser Cys Leu Thr Asn 
            340                 345                 350         


Phe Leu Leu Asn Gly Arg Ser Val Leu Leu Glu Gln Pro Arg Lys Ser 
        355                 360                 365             


Gly Ser Lys Val Ile Ser His Met Leu Ser Ser His Gly Gly Glu Ile 
    370                 375                 380                 


Phe Leu His Val Leu Ser Ser Ser Arg Ser Ile Leu Glu Asp Pro Pro 
385                 390                 395                 400 


Ser Ile Ser Glu Gly Cys Gly Gly Arg Val Thr Asp Tyr Arg Ile Thr 
                405                 410                 415     


Asp Phe Gly Glu Phe Met Arg Glu Asn Arg Leu Thr Pro Phe Leu Asp 
            420                 425                 430         


Pro Arg Tyr Lys Ile Asp Gly Ser Leu Glu Val Pro Leu Glu Arg Ala 
        435                 440                 445             


Lys Asp Gln Leu Glu Lys His Thr Arg Tyr Trp Pro Met Ile Ile Ser 
    450                 455                 460                 


Gln Thr Thr Ile Phe Asn Met Gln Ala Val Val Pro Leu Ala Ser Val 
465                 470                 475                 480 


Ile Val Lys Glu Ser Leu Thr Glu Glu Asp Val Leu Asn Cys Gln Lys 
                485                 490                 495     


Thr Ile Tyr Asn Leu Val Asp Met Glu Arg Lys Asn Asp Pro Leu Pro 
            500                 505                 510         


Ile Ser Thr Val Gly Thr Arg Gly Lys Gly Pro Lys Arg Asp Glu Gln 
        515                 520                 525             


Tyr Arg Ile Met Trp Asn Glu Leu Glu Thr Leu Val Arg Ala His Ile 
    530                 535                 540                 


Asn Asn Ser Glu Lys His Gln Arg Val Leu Glu Cys Leu Met Ala Cys 
545                 550                 555                 560 


Arg Ser Lys Pro Pro Glu Glu Glu Glu Arg Lys Lys Arg Gly Arg Lys 
                565                 570                 575     


Arg Glu Asp Lys Glu Asp Lys Ser Glu Lys Ala Val Lys Asp Tyr Glu 
            580                 585                 590         


Gln Glu Lys Ser Trp Gln Asp Ser Glu Arg Leu Lys Gly Ile Leu Glu 
        595                 600                 605             


Arg Gly Lys Glu Glu Leu Ala Glu Ala Glu Ile Ile Lys Asp Ser Pro 
    610                 615                 620                 


Asp Ser Pro Glu Pro Pro Asn Lys Lys Pro Leu Val Glu Met Asp Glu 
625                 630                 635                 640 


Thr Pro Gln Val Glu Lys Ser Lys Gly Pro Val Ser Leu Leu Ser Leu 
                645                 650                 655     


Trp Ser Asn Arg Ile Asn Thr Ala Asn Ser Arg Lys His Gln Glu Phe 
            660                 665                 670         


Ala Gly Arg Leu Asn Ser Val Asn Asn Arg Ala Glu Leu Tyr Gln His 
        675                 680                 685             


Leu Lys Glu Glu Asn Gly Met Glu Thr Thr Glu Asn Gly Lys Ala Ser 
    690                 695                 700                 


Arg Gln 
705     


<210>  865
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASXL1__Homo_sapiens__NP_001158075

<400>  865

Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg Thr Trp Ala Glu Ala 
1               5                   10                  15      


Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala Pro Met Thr Pro Lys 
            20                  25                  30          


Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys Glu Met Arg Ser 
        35                  40                  45              


Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser 
    50                  55                  60                  


Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Leu Lys Val 
                85  


<210>  866
<211>  1435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASXL2__Homo_sapiens__NP_060733

<400>  866

Met Arg Glu Lys Gly Arg Arg Lys Lys Gly Arg Thr Trp Ala Glu Ala 
1               5                   10                  15      


Ala Lys Thr Val Leu Glu Lys Tyr Pro Asn Thr Pro Met Ser His Lys 
            20                  25                  30          


Glu Ile Leu Gln Val Ile Gln Arg Glu Gly Leu Lys Glu Ile Arg Ser 
        35                  40                  45              


Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Thr Asn Ser 
    50                  55                  60                  


Arg Gly Glu Glu Gly Ile Phe Tyr Lys Val Pro Gly Arg Met Gly Val 
65                  70                  75                  80  


Tyr Thr Leu Lys Lys Asp Val Pro Asp Gly Val Lys Glu Leu Ser Glu 
                85                  90                  95      


Gly Ser Glu Glu Ser Ser Asp Gly Gln Ser Asp Ser Gln Ser Ser Glu 
            100                 105                 110         


Asn Ser Ser Ser Ser Ser Asp Gly Gly Ser Asn Lys Glu Gly Lys Lys 
        115                 120                 125             


Ser Arg Trp Lys Arg Lys Val Ser Ser Ser Ser Pro Gln Ser Gly Cys 
    130                 135                 140                 


Pro Ser Pro Thr Ile Pro Ala Gly Lys Val Ile Ser Pro Ser Gln Lys 
145                 150                 155                 160 


His Ser Lys Lys Ala Leu Lys Gln Ala Leu Lys Gln Gln Gln Gln Lys 
                165                 170                 175     


Lys Gln Gln Gln Gln Cys Arg Pro Ser Ile Ser Ile Ser Ser Asn Gln 
            180                 185                 190         


His Leu Ser Leu Lys Thr Val Lys Ala Ala Ser Asp Ser Val Pro Ala 
        195                 200                 205             


Lys Pro Ala Thr Trp Glu Gly Lys Gln Ser Asp Gly Gln Thr Gly Ser 
    210                 215                 220                 


Pro Gln Asn Ser Asn Ser Ser Phe Ser Ser Ser Val Lys Val Glu Asn 
225                 230                 235                 240 


Thr Leu Leu Gly Leu Gly Lys Lys Ser Phe Gln Arg Ser Glu Arg Leu 
                245                 250                 255     


His Thr Arg Gln Met Lys Arg Thr Lys Cys Ala Asp Ile Asp Val Glu 
            260                 265                 270         


Thr Pro Asp Ser Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn 
        275                 280                 285             


Lys His Thr Phe Ser Val Leu Pro Gly Asp Cys Gln Gln Arg Leu Leu 
    290                 295                 300                 


Leu Leu Leu Pro Glu Val Asp Arg Gln Val Gly Pro Asp Gly Leu Met 
305                 310                 315                 320 


Lys Leu Asn Gly Ser Ala Leu Asn Asn Glu Phe Phe Thr Ser Ala Ala 
                325                 330                 335     


Gln Gly Trp Lys Glu Arg Leu Ser Glu Gly Glu Phe Thr Pro Glu Met 
            340                 345                 350         


Gln Val Arg Ile Arg Gln Glu Ile Glu Lys Glu Lys Lys Val Glu Pro 
        355                 360                 365             


Trp Lys Glu Gln Phe Phe Glu Ser Tyr Tyr Gly Gln Ser Ser Gly Leu 
    370                 375                 380                 


Ser Leu Glu Asp Ser Lys Lys Leu Thr Ala Ser Pro Ser Asp Pro Lys 
385                 390                 395                 400 


Val Lys Lys Thr Pro Ala Glu Gln Pro Lys Ser Met Pro Val Ser Glu 
                405                 410                 415     


Ala Ser Leu Ile Arg Ile Val Pro Val Val Ser Gln Ser Glu Cys Lys 
            420                 425                 430         


Glu Glu Ala Leu Gln Met Ser Ser Pro Gly Arg Lys Glu Glu Cys Glu 
        435                 440                 445             


Ser Gln Gly Glu Val Gln Pro Asn Phe Ser Thr Ser Ser Glu Pro Leu 
    450                 455                 460                 


Leu Ser Ser Ala Leu Asn Thr His Glu Leu Ser Ser Ile Leu Pro Ile 
465                 470                 475                 480 


Lys Cys Pro Lys Asp Glu Asp Leu Leu Glu Gln Lys Pro Val Thr Ser 
                485                 490                 495     


Ala Glu Gln Glu Ser Glu Lys Asn His Leu Thr Thr Ala Ser Asn Tyr 
            500                 505                 510         


Asn Lys Ser Glu Ser Gln Glu Ser Leu Val Thr Ser Pro Ser Lys Pro 
        515                 520                 525             


Lys Ser Pro Gly Val Glu Lys Pro Ile Val Lys Pro Thr Ala Gly Ala 
    530                 535                 540                 


Gly Pro Gln Glu Thr Asn Met Lys Glu Pro Leu Ala Thr Leu Val Asp 
545                 550                 555                 560 


Gln Ser Pro Glu Ser Leu Lys Arg Lys Ser Ser Leu Thr Gln Glu Glu 
                565                 570                 575     


Ala Pro Val Ser Trp Glu Lys Arg Pro Arg Val Thr Glu Asn Arg Gln 
            580                 585                 590         


His Gln Gln Pro Phe Gln Val Ser Pro Gln Pro Phe Leu Asn Arg Gly 
        595                 600                 605             


Asp Arg Ile Gln Val Arg Lys Val Pro Pro Leu Lys Ile Pro Val Ser 
    610                 615                 620                 


Arg Ile Ser Pro Met Pro Phe His Pro Ser Gln Val Ser Pro Arg Ala 
625                 630                 635                 640 


Arg Phe Pro Val Ser Ile Thr Ser Pro Asn Arg Thr Gly Ala Arg Thr 
                645                 650                 655     


Leu Ala Asp Ile Lys Ala Lys Ala Gln Leu Val Lys Ala Gln Arg Ala 
            660                 665                 670         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Val Gly Gly 
        675                 680                 685             


Thr Ile Pro Gly Pro Gly Pro Gly Gly Gly Gln Gly Pro Gly Glu Gly 
    690                 695                 700                 


Gly Glu Gly Gln Thr Ala Arg Gly Gly Ser Pro Gly Ser Asp Arg Val 
705                 710                 715                 720 


Ser Glu Thr Gly Lys Gly Pro Thr Leu Glu Leu Ala Gly Thr Gly Ser 
                725                 730                 735     


Arg Gly Gly Thr Arg Glu Leu Leu Pro Cys Gly Pro Glu Thr Gln Pro 
            740                 745                 750         


Gln Ser Glu Thr Lys Thr Thr Pro Ser Gln Ala Gln Pro His Ser Val 
        755                 760                 765             


Ser Gly Ala Gln Leu Gln Gln Thr Pro Pro Val Pro Pro Thr Pro Ala 
    770                 775                 780                 


Val Ser Gly Ala Cys Thr Ser Val Pro Ser Pro Ala His Ile Glu Lys 
785                 790                 795                 800 


Leu Asp Asn Glu Lys Leu Asn Pro Thr Arg Ala Thr Ala Thr Val Ala 
                805                 810                 815     


Ser Val Ser His Pro Gln Gly Pro Ser Ser Cys Arg Gln Glu Lys Ala 
            820                 825                 830         


Pro Ser Pro Thr Gly Pro Ala Leu Ile Ser Gly Ala Ser Pro Val His 
        835                 840                 845             


Cys Ala Ala Asp Gly Thr Val Glu Leu Lys Ala Gly Pro Ser Lys Asn 
    850                 855                 860                 


Ile Pro Asn Pro Ser Ala Ser Ser Lys Thr Asp Ala Ser Val Pro Val 
865                 870                 875                 880 


Ala Val Thr Pro Ser Pro Leu Thr Ser Leu Leu Thr Thr Ala Thr Leu 
                885                 890                 895     


Glu Lys Leu Pro Val Pro Gln Val Ser Ala Thr Thr Ala Pro Ala Gly 
            900                 905                 910         


Ser Ala Pro Pro Ser Ser Thr Leu Pro Ala Ala Ser Ser Leu Lys Thr 
        915                 920                 925             


Pro Gly Thr Ser Leu Asn Met Asn Gly Pro Thr Leu Arg Pro Thr Ser 
    930                 935                 940                 


Ser Ile Pro Ala Asn Asn Pro Leu Val Thr Gln Leu Leu Gln Gly Lys 
945                 950                 955                 960 


Asp Val Pro Met Glu Gln Ile Leu Pro Lys Pro Leu Thr Lys Val Glu 
                965                 970                 975     


Met Lys Thr Val Pro Leu Thr Ala Lys Glu Glu Arg Gly Met Gly Ala 
            980                 985                 990         


Leu Ile Ala Thr Asn Thr Thr Glu  Asn Ser Thr Arg Glu  Glu Val Asn 
        995                 1000                 1005             


Glu Arg  Gln Ser His Pro Ala  Thr Gln Gln Gln Leu  Gly Lys Thr 
    1010                 1015                 1020             


Leu Gln  Ser Lys Gln Leu Pro  Gln Val Pro Arg Pro  Leu Gln Leu 
    1025                 1030                 1035             


Phe Ser  Ala Lys Glu Leu Arg  Asp Ser Ser Ile Asp  Thr His Gln 
    1040                 1045                 1050             


Tyr His  Glu Gly Leu Ser Lys  Ala Thr Gln Asp Gln  Ile Leu Gln 
    1055                 1060                 1065             


Thr Leu  Ile Gln Arg Val Arg  Arg Gln Asn Leu Leu  Ser Val Val 
    1070                 1075                 1080             


Pro Pro  Ser Gln Phe Asn Phe  Ala His Ser Gly Phe  Gln Leu Glu 
    1085                 1090                 1095             


Asp Ile  Ser Thr Ser Gln Arg  Phe Met Leu Gly Phe  Ala Gly Arg 
    1100                 1105                 1110             


Arg Thr  Ser Lys Pro Ala Met  Ala Gly His Tyr Leu  Leu Asn Ile 
    1115                 1120                 1125             


Ser Thr  Tyr Gly Arg Gly Ser  Glu Ser Phe Arg Arg  Thr His Ser 
    1130                 1135                 1140             


Val Asn  Pro Glu Asp Arg Phe  Cys Leu Ser Ser Pro  Thr Glu Ala 
    1145                 1150                 1155             


Leu Lys  Met Gly Tyr Thr Asp  Cys Lys Asn Ala Thr  Gly Glu Ser 
    1160                 1165                 1170             


Ser Ser  Ser Lys Glu Asp Asp  Thr Asp Glu Glu Ser  Thr Gly Asp 
    1175                 1180                 1185             


Glu Gln  Glu Ser Val Thr Val  Lys Glu Glu Pro Gln  Val Ser Gln 
    1190                 1195                 1200             


Ser Ala  Gly Lys Gly Asp Thr  Ser Ser Gly Pro His  Ser Arg Glu 
    1205                 1210                 1215             


Thr Leu  Ser Thr Ser Asp Cys  Leu Ala Ser Lys Asn  Val Lys Ala 
    1220                 1225                 1230             


Glu Ile  Pro Leu Asn Glu Gln  Thr Thr Leu Ser Lys  Glu Asn Tyr 
    1235                 1240                 1245             


Leu Phe  Thr Arg Gly Gln Thr  Phe Asp Glu Lys Thr  Leu Ala Arg 
    1250                 1255                 1260             


Asp Leu  Ile Gln Ala Ala Gln  Lys Gln Met Ala His  Ala Val Arg 
    1265                 1270                 1275             


Gly Lys  Ala Ile Arg Ser Ser  Pro Glu Leu Phe Ser  Ser Thr Val 
    1280                 1285                 1290             


Leu Pro  Leu Pro Ala Asp Ser  Pro Thr His Gln Pro  Leu Leu Leu 
    1295                 1300                 1305             


Pro Pro  Leu Gln Thr Pro Lys  Leu Tyr Gly Ser Pro  Thr Gln Ile 
    1310                 1315                 1320             


Gly Pro  Ser Tyr Arg Gly Met  Ile Asn Val Ser Thr  Ser Ser Asp 
    1325                 1330                 1335             


Met Asp  His Asn Ser Ala Val  Pro Gly Ser Gln Val  Ser Ser Asn 
    1340                 1345                 1350             


Val Gly  Asp Val Met Ser Phe  Ser Val Thr Val Thr  Thr Ile Pro 
    1355                 1360                 1365             


Ala Ser  Gln Ala Met Asn Pro  Ser Ser His Gly Gln  Thr Ile Pro 
    1370                 1375                 1380             


Val Gln  Ala Phe Ser Glu Glu  Asn Ser Ile Glu Gly  Thr Pro Ser 
    1385                 1390                 1395             


Lys Cys  Tyr Cys Arg Leu Lys  Ala Met Ile Met Cys  Lys Gly Cys 
    1400                 1405                 1410             


Gly Ala  Phe Cys His Asp Asp  Cys Ile Gly Pro Ser  Lys Leu Cys 
    1415                 1420                 1425             


Val Ser  Cys Leu Val Val Arg  
    1430                 1435 


<210>  867
<211>  2248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASXL3__Homo_sapiens__NP_085135

<400>  867

Met Lys Asp Lys Arg Lys Lys Lys Asp Arg Thr Trp Ala Glu Ala Ala 
1               5                   10                  15      


Arg Leu Ala Leu Glu Lys His Pro Asn Ser Pro Met Thr Ala Lys Gln 
            20                  25                  30          


Ile Leu Glu Val Ile Gln Lys Glu Gly Leu Lys Glu Thr Ser Gly Thr 
        35                  40                  45              


Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Thr Asn Thr Arg Ile 
    50                  55                  60                  


Gly Asp Gly Thr Phe Phe Lys Ile Pro Gly Lys Ser Gly Leu Tyr Ala 
65                  70                  75                  80  


Leu Lys Lys Glu Glu Ser Ser Cys Pro Ala Asp Gly Thr Leu Asp Leu 
                85                  90                  95      


Val Cys Glu Ser Glu Leu Asp Gly Thr Asp Met Ala Glu Ala Asn Ala 
            100                 105                 110         


His Gly Glu Glu Asn Gly Val Cys Ser Lys Gln Val Thr Asp Glu Ala 
        115                 120                 125             


Ser Ser Thr Arg Asp Ser Ser Leu Thr Asn Thr Ala Val Gln Ser Lys 
    130                 135                 140                 


Leu Val Ser Ser Phe Gln Gln His Thr Lys Lys Ala Leu Lys Gln Ala 
145                 150                 155                 160 


Leu Arg Gln Gln Gln Lys Arg Arg Asn Gly Val Ser Met Met Val Asn 
                165                 170                 175     


Lys Thr Val Pro Arg Val Val Leu Thr Pro Leu Lys Val Ser Asp Glu 
            180                 185                 190         


Gln Ser Asp Ser Pro Ser Gly Ser Glu Ser Lys Asn Gly Glu Ala Asp 
        195                 200                 205             


Ser Ser Asp Lys Glu Met Lys His Gly Gln Lys Ser Pro Thr Gly Lys 
    210                 215                 220                 


Gln Thr Ser Gln His Leu Lys Arg Leu Lys Lys Ser Gly Leu Gly His 
225                 230                 235                 240 


Leu Lys Trp Thr Lys Ala Glu Asp Ile Asp Ile Glu Thr Pro Gly Ser 
                245                 250                 255     


Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn Lys His Thr Phe 
            260                 265                 270         


Ala Ser Leu Pro Gln His Phe Gln Gln Tyr Leu Leu Leu Leu Leu Pro 
        275                 280                 285             


Glu Val Asp Arg Gln Met Gly Ser Asp Gly Ile Leu Arg Leu Ser Thr 
    290                 295                 300                 


Ser Ala Leu Asn Asn Glu Phe Phe Ala Tyr Ala Ala Gln Gly Trp Lys 
305                 310                 315                 320 


Gln Arg Leu Ala Glu Gly Glu Phe Thr Pro Glu Met Gln Leu Arg Ile 
                325                 330                 335     


Arg Gln Glu Ile Glu Lys Glu Lys Lys Thr Glu Pro Trp Lys Glu Lys 
            340                 345                 350         


Phe Phe Glu Arg Phe Tyr Gly Glu Lys Leu Gly Met Ser Arg Glu Glu 
        355                 360                 365             


Ser Val Lys Leu Thr Thr Gly Pro Asn Asn Ala Gly Ala Gln Ser Ser 
    370                 375                 380                 


Ser Ser Cys Gly Thr Ser Gly Leu Pro Val Ser Ala Gln Thr Ala Leu 
385                 390                 395                 400 


Ala Glu Gln Gln Pro Lys Ser Met Lys Ser Pro Ala Ser Pro Glu Pro 
                405                 410                 415     


Gly Phe Cys Ala Thr Leu Cys Pro Met Val Glu Ile Pro Pro Lys Asp 
            420                 425                 430         


Ile Met Ala Glu Leu Glu Ser Glu Asp Ile Leu Ile Pro Glu Glu Ser 
        435                 440                 445             


Val Ile Gln Glu Glu Ile Ala Glu Glu Val Glu Thr Ser Ile Cys Glu 
    450                 455                 460                 


Cys Gln Asp Glu Asn His Lys Thr Ile Pro Glu Phe Ser Glu Glu Ala 
465                 470                 475                 480 


Glu Ser Leu Thr Asn Ser His Glu Glu Pro Gln Ile Ala Pro Pro Glu 
                485                 490                 495     


Asp Asn Leu Glu Ser Cys Val Met Met Asn Asp Val Leu Glu Thr Leu 
            500                 505                 510         


Pro His Ile Glu Val Lys Ile Glu Gly Lys Ser Glu Ser Pro Gln Glu 
        515                 520                 525             


Glu Met Thr Val Val Ile Asp Gln Leu Glu Val Cys Asp Ser Leu Ile 
    530                 535                 540                 


Pro Ser Thr Ser Ser Met Thr His Val Ser Asp Thr Glu His Lys Glu 
545                 550                 555                 560 


Ser Glu Thr Ala Val Glu Thr Ser Thr Pro Lys Ile Lys Thr Gly Ser 
                565                 570                 575     


Ser Ser Leu Glu Gly Gln Phe Pro Asn Glu Gly Ile Ala Ile Asp Met 
            580                 585                 590         


Glu Leu Gln Ser Asp Pro Glu Glu Gln Leu Ser Glu Asn Ala Cys Ile 
        595                 600                 605             


Ser Glu Thr Ser Phe Ser Ser Glu Ser Pro Glu Gly Ala Cys Thr Ser 
    610                 615                 620                 


Leu Pro Ser Pro Gly Gly Glu Thr Gln Ser Thr Ser Glu Glu Ser Cys 
625                 630                 635                 640 


Thr Pro Ala Ser Leu Glu Thr Thr Phe Cys Ser Glu Val Ser Ser Thr 
                645                 650                 655     


Glu Asn Thr Asp Lys Tyr Asn Gln Arg Asn Ser Thr Asp Glu Asn Phe 
            660                 665                 670         


His Ala Ser Leu Met Ser Glu Ile Ser Pro Ile Ser Thr Ser Pro Glu 
        675                 680                 685             


Ile Ser Glu Ala Ser Leu Met Ser Asn Leu Pro Leu Thr Ser Glu Ala 
    690                 695                 700                 


Ser Pro Val Ser Asn Leu Pro Leu Thr Ser Glu Thr Ser Pro Met Ser 
705                 710                 715                 720 


Asp Leu Pro Leu Thr Ser Glu Thr Ser Ser Val Ser Ser Met Leu Leu 
                725                 730                 735     


Thr Ser Glu Thr Thr Phe Val Ser Ser Leu Pro Leu Pro Ser Glu Thr 
            740                 745                 750         


Ser Pro Ile Ser Asn Ser Ser Ile Asn Glu Arg Met Ala His Gln Gln 
        755                 760                 765             


Arg Lys Ser Pro Ser Val Ser Glu Glu Pro Leu Ser Pro Gln Lys Asp 
    770                 775                 780                 


Glu Ser Ser Ala Thr Ala Lys Pro Leu Gly Glu Asn Leu Thr Ser Gln 
785                 790                 795                 800 


Gln Lys Asn Leu Ser Asn Thr Pro Glu Pro Ile Ile Met Ser Ser Ser 
                805                 810                 815     


Ser Ile Ala Pro Glu Ala Phe Pro Ser Glu Asp Leu His Asn Lys Thr 
            820                 825                 830         


Leu Ser Gln Gln Thr Cys Lys Ser His Val Asp Thr Glu Lys Pro Tyr 
        835                 840                 845             


Pro Ala Ser Ile Pro Glu Leu Ala Ser Thr Glu Met Ile Lys Val Lys 
    850                 855                 860                 


Asn His Ser Val Leu Gln Arg Thr Glu Lys Lys Val Leu Pro Ser Pro 
865                 870                 875                 880 


Leu Glu Leu Ser Val Phe Ser Glu Gly Thr Asp Asn Lys Gly Asn Glu 
                885                 890                 895     


Leu Pro Ser Ala Lys Leu Gln Asp Lys Gln Tyr Ile Ser Ser Val Asp 
            900                 905                 910         


Lys Ala Pro Phe Ser Glu Gly Ser Arg Asn Lys Thr His Lys Gln Gly 
        915                 920                 925             


Ser Thr Gln Ser Arg Leu Glu Thr Ser His Thr Ser Lys Ser Ser Glu 
    930                 935                 940                 


Pro Ser Lys Ser Pro Asp Gly Ile Arg Asn Glu Ser Arg Asp Ser Glu 
945                 950                 955                 960 


Ile Ser Lys Arg Lys Thr Ala Glu Gln His Ser Phe Gly Ile Cys Lys 
                965                 970                 975     


Glu Lys Arg Ala Arg Ile Glu Asp Asp Gln Ser Thr Arg Asn Ile Ser 
            980                 985                 990         


Ser Ser Ser Pro Pro Glu Lys Glu  Gln Pro Pro Arg Glu  Glu Pro Arg 
        995                 1000                 1005             


Val Pro  Pro Leu Lys Ile Gln  Leu Ser Lys Ile Gly  Pro Pro Phe 
    1010                 1015                 1020             


Ile Ile  Lys Ser Gln Pro Val  Ser Lys Pro Glu Ser  Arg Ala Ser 
    1025                 1030                 1035             


Thr Ser  Thr Ser Val Ser Gly  Gly Arg Asn Thr Gly  Ala Arg Thr 
    1040                 1045                 1050             


Leu Ala  Asp Ile Lys Ala Arg  Ala Gln Gln Ala Arg  Ala Gln Arg 
    1055                 1060                 1065             


Glu Ala  Ala Ala Ala Ala Ala  Val Ala Ala Ala Ala  Ser Ile Val 
    1070                 1075                 1080             


Ser Gly  Ala Met Gly Ser Pro  Gly Glu Gly Gly Lys  Thr Arg Thr 
    1085                 1090                 1095             


Leu Ala  His Ile Lys Glu Gln  Thr Lys Ala Lys Leu  Phe Ala Lys 
    1100                 1105                 1110             


His Gln  Ala Arg Ala His Leu  Phe Gln Thr Ser Lys  Glu Thr Arg 
    1115                 1120                 1125             


Leu Pro  Pro Pro Leu Ser Ser  Lys Glu Gly Pro Pro  Asn Leu Glu 
    1130                 1135                 1140             


Val Ser  Ser Thr Pro Glu Thr  Lys Met Glu Gly Ser  Thr Gly Val 
    1145                 1150                 1155             


Ile Ile  Val Asn Pro Asn Cys  Arg Ser Pro Ser Asn  Lys Ser Ala 
    1160                 1165                 1170             


His Leu  Arg Glu Thr Thr Thr  Val Leu Gln Gln Ser  Leu Asn Pro 
    1175                 1180                 1185             


Ser Lys  Leu Pro Glu Thr Ala  Thr Asp Leu Ser Val  His Ser Ser 
    1190                 1195                 1200             


Asp Glu  Asn Ile Pro Val Ser  His Leu Ser Glu Lys  Ile Val Ser 
    1205                 1210                 1215             


Ser Thr  Ser Ser Glu Asn Ser  Ser Val Pro Met Leu  Phe Asn Lys 
    1220                 1225                 1230             


Asn Ser  Val Pro Val Ser Val  Cys Ser Thr Ala Ile  Ser Gly Ala 
    1235                 1240                 1245             


Ile Lys  Glu His Pro Phe Val  Ser Ser Val Asp Lys  Ser Ser Val 
    1250                 1255                 1260             


Leu Met  Ser Val Asp Ser Ala  Asn Thr Thr Ile Ser  Ala Cys Asn 
    1265                 1270                 1275             


Ile Ser  Met Leu Lys Thr Ile  Gln Gly Thr Asp Thr  Pro Cys Ile 
    1280                 1285                 1290             


Ala Ile  Ile Pro Lys Cys Ile  Glu Ser Thr Pro Ile  Ser Ala Thr 
    1295                 1300                 1305             


Thr Glu  Gly Ser Ser Ile Ser  Ser Ser Met Asp Asp  Lys Gln Leu 
    1310                 1315                 1320             


Leu Ile  Ser Ser Ser Ser Ala  Ser Asn Leu Val Ser  Thr Gln Tyr 
    1325                 1330                 1335             


Thr Ser  Val Pro Thr Pro Ser  Ile Gly Asn Asn Leu  Pro Asn Leu 
    1340                 1345                 1350             


Ser Thr  Ser Ser Val Leu Ile  Pro Pro Met Gly Ile  Asn Asn Arg 
    1355                 1360                 1365             


Phe Pro  Ser Glu Lys Ile Ala  Ile Pro Gly Ser Glu  Glu Gln Ala 
    1370                 1375                 1380             


Thr Val  Ser Met Gly Thr Thr  Val Arg Ala Ala Leu  Ser Cys Ser 
    1385                 1390                 1395             


Asp Ser  Val Ala Val Thr Asp  Ser Leu Val Ala His  Pro Thr Val 
    1400                 1405                 1410             


Ala Met  Phe Thr Gly Asn Met  Leu Thr Ile Asn Ser  Tyr Asp Ser 
    1415                 1420                 1425             


Pro Pro  Lys Leu Ser Ala Glu  Ser Leu Asp Lys Asn  Ser Gly Pro 
    1430                 1435                 1440             


Arg Asn  Arg Ala Asp Asn Ser  Gly Lys Pro Gln Gln  Pro Pro Gly 
    1445                 1450                 1455             


Gly Phe  Ala Pro Ala Ala Ile  Asn Arg Ser Ile Pro  Cys Lys Val 
    1460                 1465                 1470             


Ile Val  Asp His Ser Thr Thr  Leu Thr Ser Ser Leu  Ser Leu Thr 
    1475                 1480                 1485             


Val Ser  Val Glu Ser Ser Glu  Ala Ser Leu Asp Leu  Gln Gly Arg 
    1490                 1495                 1500             


Pro Val  Arg Thr Glu Ala Ser  Val Gln Pro Val Ala  Cys Pro Gln 
    1505                 1510                 1515             


Val Ser  Val Ile Ser Arg Pro  Glu Pro Val Ala Asn  Glu Gly Ile 
    1520                 1525                 1530             


Asp His  Ser Ser Thr Phe Ile  Ala Ala Ser Ala Ala  Lys Gln Asp 
    1535                 1540                 1545             


Ser Lys  Thr Leu Pro Ala Thr  Cys Thr Ser Leu Arg  Glu Leu Pro 
    1550                 1555                 1560             


Leu Val  Pro Asp Lys Leu Asn  Glu Pro Thr Ala Pro  Ser His Asn 
    1565                 1570                 1575             


Phe Ala  Glu Gln Ala Arg Gly  Pro Ala Pro Phe Lys  Ser Glu Ala 
    1580                 1585                 1590             


Asp Thr  Thr Cys Ser Asn Gln  Tyr Asn Pro Ser Asn  Arg Ile Cys 
    1595                 1600                 1605             


Trp Asn  Asp Asp Gly Met Arg  Ser Thr Gly Gln Pro  Leu Val Thr 
    1610                 1615                 1620             


His Ser  Gly Ser Ser Lys Gln  Lys Glu Tyr Leu Glu  Gln Ser Cys 
    1625                 1630                 1635             


Pro Lys  Ala Ile Lys Thr Glu  His Ala Asn Tyr Leu  Asn Val Ser 
    1640                 1645                 1650             


Glu Leu  His Pro Arg Asn Leu  Val Thr Asn Val Ala  Leu Pro Val 
    1655                 1660                 1665             


Lys Ser  Glu Leu His Glu Ala  Asp Lys Gly Phe Arg  Met Asp Thr 
    1670                 1675                 1680             


Glu Asp  Phe Pro Gly Pro Glu  Leu Pro Pro Pro Ala  Ala Glu Gly 
    1685                 1690                 1695             


Ala Ser  Ser Val Gln Gln Thr  Gln Asn Met Lys Ala  Ser Thr Ser 
    1700                 1705                 1710             


Ser Pro  Met Glu Glu Ala Ile  Ser Leu Ala Thr Asp  Ala Leu Lys 
    1715                 1720                 1725             


Arg Val  Pro Gly Ala Gly Ser  Ser Gly Cys Arg Leu  Ser Ser Val 
    1730                 1735                 1740             


Glu Ala  Asn Asn Pro Leu Val  Thr Gln Leu Leu Gln  Gly Asn Leu 
    1745                 1750                 1755             


Pro Leu  Glu Lys Val Leu Pro  Gln Pro Arg Leu Gly  Ala Lys Leu 
    1760                 1765                 1770             


Glu Ile  Asn Arg Leu Pro Leu  Pro Leu Gln Thr Thr  Ser Val Gly 
    1775                 1780                 1785             


Lys Thr  Ala Pro Glu Arg Asn  Val Glu Ile Pro Pro  Ser Ser Pro 
    1790                 1795                 1800             


Asn Pro  Asp Gly Lys Gly Tyr  Leu Ala Gly Thr Leu  Ala Pro Leu 
    1805                 1810                 1815             


Gln Met  Arg Lys Arg Glu Asn  His Pro Lys Lys Arg  Val Ala Arg 
    1820                 1825                 1830             


Thr Val  Gly Glu His Thr Gln  Val Lys Cys Glu Pro  Gly Lys Leu 
    1835                 1840                 1845             


Leu Val  Glu Pro Asp Val Lys  Gly Val Pro Cys Val  Ile Ser Ser 
    1850                 1855                 1860             


Gly Ile  Ser Gln Leu Gly His  Ser Gln Pro Phe Lys  Gln Glu Trp 
    1865                 1870                 1875             


Leu Asn  Lys His Ser Met Gln  Asn Arg Ile Val His  Ser Pro Glu 
    1880                 1885                 1890             


Val Lys  Gln Gln Lys Arg Leu  Leu Pro Ser Cys Ser  Phe Gln Gln 
    1895                 1900                 1905             


Asn Leu  Phe His Val Asp Lys  Asn Gly Gly Phe His  Thr Asp Ala 
    1910                 1915                 1920             


Gly Thr  Ser His Arg Gln Gln  Phe Tyr Gln Met Pro  Val Ala Ala 
    1925                 1930                 1935             


Arg Gly  Pro Ile Pro Thr Ala  Ala Leu Leu Gln Ala  Ser Ser Lys 
    1940                 1945                 1950             


Thr Pro  Val Gly Cys Asn Ala  Phe Ala Phe Asn Arg  His Leu Glu 
    1955                 1960                 1965             


Gln Lys  Gly Leu Gly Glu Val  Ser Leu Ser Ser Ala  Pro His Gln 
    1970                 1975                 1980             


Leu Arg  Leu Ala Asn Met Leu  Ser Pro Asn Met Pro  Met Lys Glu 
    1985                 1990                 1995             


Gly Asp  Glu Val Gly Gly Thr  Ala His Thr Met Pro  Asn Lys Ala 
    2000                 2005                 2010             


Leu Val  His Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    2015                 2020                 2025             


Leu Ala  Leu Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Leu Pro Pro 
    2030                 2035                 2040             


Pro Leu  Pro Asn Ala Glu Val  Pro Ser Asp Gln Lys  Gln Pro Pro 
    2045                 2050                 2055             


Val Thr  Met Glu Thr Thr Lys  Arg Leu Ser Trp Pro  Gln Ser Thr 
    2060                 2065                 2070             


Gly Ile  Cys Ser Asn Ile Lys  Ser Glu Pro Leu Ser  Phe Glu Glu 
    2075                 2080                 2085             


Gly Leu  Ser Ser Ser Cys Glu  Leu Gly Met Lys Gln  Val Ser Tyr 
    2090                 2095                 2100             


Asp Gln  Asn Glu Met Lys Glu  Gln Leu Lys Ala Phe  Ala Leu Lys 
    2105                 2110                 2115             


Ser Ala  Asp Phe Ser Ser Tyr  Leu Leu Ser Glu Pro  Gln Lys Pro 
    2120                 2125                 2130             


Phe Thr  Gln Leu Ala Ala Gln  Lys Met Gln Val Gln  Gln Gln Gln 
    2135                 2140                 2145             


Gln Leu  Cys Gly Asn Tyr Pro  Thr Ile His Phe Gly  Ser Thr Ser 
    2150                 2155                 2160             


Phe Lys  Arg Ala Ala Ser Ala  Ile Glu Lys Ser Ile  Gly Ile Leu 
    2165                 2170                 2175             


Gly Ser  Gly Ser Asn Pro Ala  Thr Gly Leu Ser Gly  Gln Asn Ala 
    2180                 2185                 2190             


Gln Met  Pro Val Gln Asn Phe  Ala Asp Ser Ser Asn  Ala Asp Glu 
    2195                 2200                 2205             


Leu Glu  Leu Lys Cys Ser Cys  Arg Leu Lys Ala Met  Ile Val Cys 
    2210                 2215                 2220             


Lys Gly  Cys Gly Ala Phe Cys  His Asp Asp Cys Ile  Gly Pro Ser 
    2225                 2230                 2235             


Lys Leu  Cys Val Ala Cys Leu  Val Val Arg 
    2240                 2245             


<210>  868
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASZ1__Homo_sapiens__NP_570124

<400>  868

Met Ala Ala Ser Ala Leu Arg Gly Leu Pro Val Ala Gly Gly Gly Glu 
1               5                   10                  15      


Ser Ser Glu Ser Glu Asp Asp Gly Trp Glu Ile Gly Tyr Leu Asp Arg 
            20                  25                  30          


Thr Ser Gln Lys Leu Lys Arg Leu Leu Pro Ile Glu Glu Lys Lys Glu 
        35                  40                  45              


Lys Phe Lys Lys Ala Met Thr Ile Gly Asp Val Ser Leu Val Gln Glu 
    50                  55                  60                  


Leu Leu Asp Ser Gly Ile Ser Val Asp Ser Asn Phe Gln Tyr Gly Trp 
65                  70                  75                  80  


Thr Pro Leu Met Tyr Ala Ala Ser Val Ala Asn Ala Glu Leu Val Arg 
                85                  90                  95      


Val Leu Leu Asp Arg Gly Ala Asn Ala Ser Phe Glu Lys Asp Lys Gln 
            100                 105                 110         


Ser Ile Leu Ile Thr Ala Cys Ser Ala His Gly Ser Glu Glu Gln Ile 
        115                 120                 125             


Leu Lys Cys Val Glu Leu Leu Leu Ser Arg Asn Ala Asp Pro Asn Val 
    130                 135                 140                 


Ala Cys Arg Arg Leu Met Thr Pro Ile Met Tyr Ala Ala Arg Asp Gly 
145                 150                 155                 160 


His Thr Gln Val Val Ala Leu Leu Val Ala His Gly Ala Glu Val Asn 
                165                 170                 175     


Thr Gln Asp Glu Asn Gly Tyr Thr Ala Leu Thr Trp Ala Ala Arg Gln 
            180                 185                 190         


Gly His Lys Asn Ile Val Leu Lys Leu Leu Glu Leu Gly Ala Asn Lys 
        195                 200                 205             


Met Leu Gln Thr Lys Asp Gly Lys Met Pro Ser Glu Ile Ala Lys Arg 
    210                 215                 220                 


Asn Lys His His Glu Ile Phe Asn Leu Leu Ser Phe Thr Leu Asn Pro 
225                 230                 235                 240 


Leu Glu Gly Lys Leu Gln Gln Leu Thr Lys Glu Asp Thr Ile Cys Lys 
                245                 250                 255     


Ile Leu Thr Thr Asp Ser Asp Arg Glu Lys Asp His Ile Phe Ser Ser 
            260                 265                 270         


Tyr Thr Ala Phe Gly Asp Leu Glu Val Phe Leu His Gly Leu Gly Leu 
        275                 280                 285             


Glu His Met Thr Asp Leu Leu Lys Glu Arg Asp Ile Thr Leu Arg His 
    290                 295                 300                 


Leu Leu Thr Met Arg Glu Asp Glu Phe Thr Lys Asn Gly Ile Thr Ser 
305                 310                 315                 320 


Lys Asp Gln Gln Lys Ile Leu Ala Ala Leu Lys Glu Leu Gln Val Glu 
                325                 330                 335     


Glu Ile Gln Phe Gly Glu Leu Ser Glu Glu Thr Lys Leu Glu Ile Ser 
            340                 345                 350         


Gly Asp Glu Phe Leu Asn Phe Leu Leu Lys Leu Asn Lys Gln Cys Gly 
        355                 360                 365             


His Leu Ile Thr Ala Val Gln Asn Val Ile Thr Glu Leu Pro Val Asn 
    370                 375                 380                 


Ser Gln Lys Ile Thr Leu Glu Trp Ala Ser Pro Gln Asn Phe Thr Ser 
385                 390                 395                 400 


Val Cys Glu Glu Leu Val Asn Asn Val Glu Asp Leu Ser Glu Lys Val 
                405                 410                 415     


Cys Lys Leu Lys Asp Leu Ile Gln Lys Leu Gln Asn Glu Arg Glu Asn 
            420                 425                 430         


Asp Pro Thr His Ile Gln Leu Arg Glu Glu Val Ser Thr Trp Asn Ser 
        435                 440                 445             


Arg Ile Leu Lys Arg Thr Ala Ile Thr Ile Cys Gly Phe Gly Phe Leu 
    450                 455                 460                 


Leu Phe Ile Cys Lys Leu Thr Phe Gln Arg Lys 
465                 470                 475 


<210>  869
<211>  1390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATAD2__Homo_sapiens__NP_054828

<400>  869

Met Val Val Leu Arg Ser Ser Leu Glu Leu His Asn His Ser Ala Ala 
1               5                   10                  15      


Ser Ala Thr Gly Ser Leu Asp Leu Ser Ser Asp Phe Leu Ser Leu Glu 
            20                  25                  30          


His Ile Gly Arg Arg Arg Leu Arg Ser Ala Gly Ala Ala Gln Lys Lys 
        35                  40                  45              


Pro Ala Ala Thr Thr Ala Lys Ala Gly Asp Gly Ser Ser Val Lys Glu 
    50                  55                  60                  


Val Glu Thr Tyr His Arg Thr Arg Ala Leu Arg Ser Leu Arg Lys Asp 
65                  70                  75                  80  


Ala Gln Asn Ser Ser Asp Ser Ser Phe Glu Lys Asn Val Glu Ile Thr 
                85                  90                  95      


Glu Gln Leu Ala Asn Gly Arg His Phe Thr Arg Gln Leu Ala Arg Gln 
            100                 105                 110         


Gln Ala Asp Lys Lys Lys Glu Glu His Arg Glu Asp Lys Val Ile Pro 
        115                 120                 125             


Val Thr Arg Ser Leu Arg Ala Arg Asn Ile Val Gln Ser Thr Glu His 
    130                 135                 140                 


Leu His Glu Asp Asn Gly Asp Val Glu Val Arg Arg Ser Cys Arg Ile 
145                 150                 155                 160 


Arg Ser Arg Tyr Ser Gly Val Asn Gln Ser Met Leu Phe Asp Lys Leu 
                165                 170                 175     


Ile Thr Asn Thr Ala Glu Ala Val Leu Gln Lys Met Asp Asp Met Lys 
            180                 185                 190         


Lys Met Arg Arg Gln Arg Met Arg Glu Leu Glu Asp Leu Gly Val Phe 
        195                 200                 205             


Asn Glu Thr Glu Glu Ser Asn Leu Asn Met Tyr Thr Arg Gly Lys Gln 
    210                 215                 220                 


Lys Asp Ile Gln Arg Thr Asp Glu Glu Thr Thr Asp Asn Gln Glu Gly 
225                 230                 235                 240 


Ser Val Glu Ser Ser Glu Glu Gly Glu Asp Gln Glu His Glu Asp Asp 
                245                 250                 255     


Gly Glu Asp Glu Asp Asp Glu Asp Asp Asp Asp Asp Asp Asp Asp Asp 
            260                 265                 270         


Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Glu Glu Asp Gly Glu Glu 
        275                 280                 285             


Glu Asn Gln Lys Arg Tyr Tyr Leu Arg Gln Arg Lys Ala Thr Val Tyr 
    290                 295                 300                 


Tyr Gln Ala Pro Leu Glu Lys Pro Arg His Gln Arg Lys Pro Asn Ile 
305                 310                 315                 320 


Phe Tyr Ser Gly Pro Ala Ser Pro Ala Arg Pro Arg Tyr Arg Leu Ser 
                325                 330                 335     


Ser Ala Gly Pro Arg Ser Pro Tyr Cys Lys Arg Met Asn Arg Arg Arg 
            340                 345                 350         


His Ala Ile His Ser Ser Asp Ser Thr Ser Ser Ser Ser Ser Glu Asp 
        355                 360                 365             


Glu Gln His Phe Glu Arg Arg Arg Lys Arg Ser Arg Asn Arg Ala Ile 
    370                 375                 380                 


Asn Arg Cys Leu Pro Leu Asn Phe Arg Lys Asp Glu Leu Lys Gly Ile 
385                 390                 395                 400 


Tyr Lys Asp Arg Met Lys Ile Gly Ala Ser Leu Ala Asp Val Asp Pro 
                405                 410                 415     


Met Gln Leu Asp Ser Ser Val Arg Phe Asp Ser Val Gly Gly Leu Ser 
            420                 425                 430         


Asn His Ile Ala Ala Leu Lys Glu Met Val Val Phe Pro Leu Leu Tyr 
        435                 440                 445             


Pro Glu Val Phe Glu Lys Phe Lys Ile Gln Pro Pro Arg Gly Cys Leu 
    450                 455                 460                 


Phe Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Val Ala Arg Ala Leu 
465                 470                 475                 480 


Ala Asn Glu Cys Ser Gln Gly Asp Lys Arg Val Ala Phe Phe Met Arg 
                485                 490                 495     


Lys Gly Ala Asp Cys Leu Ser Lys Trp Val Gly Glu Ser Glu Arg Gln 
            500                 505                 510         


Leu Arg Leu Leu Phe Asp Gln Ala Tyr Gln Met Arg Pro Ser Ile Ile 
        515                 520                 525             


Phe Phe Asp Glu Ile Asp Gly Leu Ala Pro Val Arg Ser Ser Arg Gln 
    530                 535                 540                 


Asp Gln Ile His Ser Ser Ile Val Ser Thr Leu Leu Ala Leu Met Asp 
545                 550                 555                 560 


Gly Leu Asp Ser Arg Gly Glu Ile Val Val Ile Gly Ala Thr Asn Arg 
                565                 570                 575     


Leu Asp Ser Ile Asp Pro Ala Leu Arg Arg Pro Gly Arg Phe Asp Arg 
            580                 585                 590         


Glu Phe Leu Phe Ser Leu Pro Asp Lys Glu Ala Arg Lys Glu Ile Leu 
        595                 600                 605             


Lys Ile His Thr Arg Asp Trp Asn Pro Lys Pro Leu Asp Thr Phe Leu 
    610                 615                 620                 


Glu Glu Leu Ala Glu Asn Cys Val Gly Tyr Cys Gly Ala Asp Ile Lys 
625                 630                 635                 640 


Ser Ile Cys Ala Glu Ala Ala Leu Cys Ala Leu Arg Arg Arg Tyr Pro 
                645                 650                 655     


Gln Ile Tyr Thr Thr Ser Glu Lys Leu Gln Leu Asp Leu Ser Ser Ile 
            660                 665                 670         


Asn Ile Ser Ala Lys Asp Phe Glu Val Ala Met Gln Lys Met Ile Pro 
        675                 680                 685             


Ala Ser Gln Arg Ala Val Thr Ser Pro Gly Gln Ala Leu Ser Thr Val 
    690                 695                 700                 


Val Lys Pro Leu Leu Gln Asn Thr Val Asp Lys Ile Leu Glu Ala Leu 
705                 710                 715                 720 


Gln Arg Val Phe Pro His Ala Glu Phe Arg Thr Asn Lys Thr Leu Asp 
                725                 730                 735     


Ser Asp Ile Ser Cys Pro Leu Leu Glu Ser Asp Leu Ala Tyr Ser Asp 
            740                 745                 750         


Asp Asp Val Pro Ser Val Tyr Glu Asn Gly Leu Ser Gln Lys Ser Ser 
        755                 760                 765             


His Lys Ala Lys Asp Asn Phe Asn Phe Leu His Leu Asn Arg Asn Ala 
    770                 775                 780                 


Cys Tyr Gln Pro Met Ser Phe Arg Pro Arg Ile Leu Ile Val Gly Glu 
785                 790                 795                 800 


Pro Gly Phe Gly Gln Gly Ser His Leu Ala Pro Ala Val Ile His Ala 
                805                 810                 815     


Leu Glu Lys Phe Thr Val Tyr Thr Leu Asp Ile Pro Val Leu Phe Gly 
            820                 825                 830         


Val Ser Thr Thr Ser Pro Glu Glu Thr Cys Ala Gln Val Ile Arg Glu 
        835                 840                 845             


Ala Lys Arg Thr Ala Pro Ser Ile Val Tyr Val Pro His Ile His Val 
    850                 855                 860                 


Trp Trp Glu Ile Val Gly Pro Thr Leu Lys Ala Thr Phe Thr Thr Leu 
865                 870                 875                 880 


Leu Gln Asn Ile Pro Ser Phe Ala Pro Val Leu Leu Leu Ala Thr Ser 
                885                 890                 895     


Asp Lys Pro His Ser Ala Leu Pro Glu Glu Val Gln Glu Leu Phe Ile 
            900                 905                 910         


Arg Asp Tyr Gly Glu Ile Phe Asn Val Gln Leu Pro Asp Lys Glu Glu 
        915                 920                 925             


Arg Thr Lys Phe Phe Glu Asp Leu Ile Leu Lys Gln Ala Ala Lys Pro 
    930                 935                 940                 


Pro Ile Ser Lys Lys Lys Ala Val Leu Gln Ala Leu Glu Val Leu Pro 
945                 950                 955                 960 


Val Ala Pro Pro Pro Glu Pro Arg Ser Leu Thr Ala Glu Glu Val Lys 
                965                 970                 975     


Arg Leu Glu Glu Gln Glu Glu Asp Thr Phe Arg Glu Leu Arg Ile Phe 
            980                 985                 990         


Leu Arg Asn Val Thr His Arg Leu  Ala Ile Asp Lys Arg  Phe Arg Val 
        995                 1000                 1005             


Phe Thr  Lys Pro Val Asp Pro  Asp Glu Val Pro Asp  Tyr Val Thr 
    1010                 1015                 1020             


Val Ile  Lys Gln Pro Met Asp  Leu Ser Ser Val Ile  Ser Lys Ile 
    1025                 1030                 1035             


Asp Leu  His Lys Tyr Leu Thr  Val Lys Asp Tyr Leu  Arg Asp Ile 
    1040                 1045                 1050             


Asp Leu  Ile Cys Ser Asn Ala  Leu Glu Tyr Asn Pro  Asp Arg Asp 
    1055                 1060                 1065             


Pro Gly  Asp Arg Leu Ile Arg  His Arg Ala Cys Ala  Leu Arg Asp 
    1070                 1075                 1080             


Thr Ala  Tyr Ala Ile Ile Lys  Glu Glu Leu Asp Glu  Asp Phe Glu 
    1085                 1090                 1095             


Gln Leu  Cys Glu Glu Ile Gln  Glu Ser Arg Lys Lys  Arg Gly Cys 
    1100                 1105                 1110             


Ser Ser  Ser Lys Tyr Ala Pro  Ser Tyr Tyr His Val  Met Pro Lys 
    1115                 1120                 1125             


Gln Asn  Ser Thr Leu Val Gly  Asp Lys Arg Ser Asp  Pro Glu Gln 
    1130                 1135                 1140             


Asn Glu  Lys Leu Lys Thr Pro  Ser Thr Pro Val Ala  Cys Ser Thr 
    1145                 1150                 1155             


Pro Ala  Gln Leu Lys Arg Lys  Ile Arg Lys Lys Ser  Asn Trp Tyr 
    1160                 1165                 1170             


Leu Gly  Thr Ile Lys Lys Arg  Arg Lys Ile Ser Gln  Ala Lys Asp 
    1175                 1180                 1185             


Asp Ser  Gln Asn Ala Ile Asp  His Lys Ile Glu Ser  Asp Thr Glu 
    1190                 1195                 1200             


Glu Thr  Gln Asp Thr Ser Val  Asp His Asn Glu Thr  Gly Asn Thr 
    1205                 1210                 1215             


Gly Glu  Ser Ser Val Glu Glu  Asn Glu Lys Gln Gln  Asn Ala Ser 
    1220                 1225                 1230             


Glu Ser  Lys Leu Glu Leu Arg  Asn Asn Ser Asn Thr  Cys Asn Ile 
    1235                 1240                 1245             


Glu Asn  Glu Leu Glu Asp Ser  Arg Lys Thr Thr Ala  Cys Thr Glu 
    1250                 1255                 1260             


Leu Arg  Asp Lys Ile Ala Cys  Asn Gly Asp Ala Ser  Ser Ser Gln 
    1265                 1270                 1275             


Ile Ile  His Ile Ser Asp Glu  Asn Glu Gly Lys Glu  Met Cys Val 
    1280                 1285                 1290             


Leu Arg  Met Thr Arg Ala Arg  Arg Ser Gln Val Glu  Gln Gln Gln 
    1295                 1300                 1305             


Leu Ile  Thr Val Glu Lys Ala  Leu Ala Ile Leu Ser  Gln Pro Thr 
    1310                 1315                 1320             


Pro Ser  Leu Val Val Asp His  Glu Arg Leu Lys Asn  Leu Leu Lys 
    1325                 1330                 1335             


Thr Val  Val Lys Lys Ser Gln  Asn Tyr Asn Ile Phe  Gln Leu Glu 
    1340                 1345                 1350             


Asn Leu  Tyr Ala Val Ile Ser  Gln Cys Ile Tyr Arg  His Arg Lys 
    1355                 1360                 1365             


Asp His  Asp Lys Thr Ser Leu  Ile Gln Lys Met Glu  Gln Glu Val 
    1370                 1375                 1380             


Glu Asn  Phe Ser Cys Ser Arg  
    1385                 1390 


<210>  870
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATAD3B__Homo_sapiens__XP_011540545

<400>  870

Met Arg Arg Ala Thr Val Glu Arg Glu Met Glu Leu Arg His Lys Asn 
1               5                   10                  15      


Glu Met Leu Arg Val Glu Thr Glu Ala Arg Ala Arg Ala Lys Ala Glu 
            20                  25                  30          


Arg Glu Asn Ala Asp Ile Ile Arg Glu Gln Ile Arg Leu Lys Ala Ser 
        35                  40                  45              


Glu His Arg Gln Thr Val Leu Glu Ser Ile Arg Thr Ala Gly Thr Leu 
    50                  55                  60                  


Phe Gly Glu Gly Phe Arg Ala Phe Val Thr Asp Arg Asp Lys Val Thr 
65                  70                  75                  80  


Ala Thr Val Ala Gly Leu Thr Leu Leu Ala Val Gly Val Tyr Ser Ala 
                85                  90                  95      


Lys Asn Ala Thr Ala Val Thr Gly Arg Phe Ile Glu Ala Arg Leu Gly 
            100                 105                 110         


Lys Pro Ser Leu Val Arg Glu Thr Ser Arg Ile Thr Val Leu Glu Ala 
        115                 120                 125             


Leu Arg His Pro Ile Gln Val Ser Arg Arg Leu Leu Ser Arg Pro Gln 
    130                 135                 140                 


Asp Val Leu Glu Gly Val Val Leu Ser Pro Ser Leu Glu Ala Arg Val 
145                 150                 155                 160 


Arg Asp Ile Ala Ile Ala Thr Arg Asn Thr Lys Lys Asn Arg Gly Leu 
                165                 170                 175     


Tyr Arg His Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu 
            180                 185                 190         


Phe Ala Lys Lys Leu Ala Leu His Ser Gly Met Asp Tyr Ala Ile Met 
        195                 200                 205             


Thr Gly Gly Asp Val Ala Pro Met Gly Arg Glu Gly Val Thr Ala Met 
    210                 215                 220                 


His Lys Leu Phe Asp Trp Ala Asn Thr Ser Arg Arg Gly Leu Leu Leu 
225                 230                 235                 240 


Phe Met Asp Glu Ala Asp Ala Phe Leu Arg Lys Arg Ala Thr Glu Glu 
                245                 250                 255     


Ile Ser Lys Asp Leu Arg Ala Thr Leu Asn Ala Phe Leu Tyr His Met 
            260                 265                 270         


Gly Gln His Ser Asn Lys Phe Met Leu Val Leu Ala Ser Asn Leu Pro 
        275                 280                 285             


Glu Gln Phe Asp Cys Ala Ile Asn Ser Arg Ile Asp Val Met Val His 
    290                 295                 300                 


Phe Asp Leu Pro Gln Gln Glu Glu Arg Glu Arg Leu Val Arg Leu His 
305                 310                 315                 320 


Phe Asp Asn Cys Val Leu Lys Pro Ala Thr Glu Gly Lys Arg Arg Leu 
                325                 330                 335     


Lys Leu Ala Gln Phe Asp Tyr Gly Arg Lys Cys Ser Glu Val Ala Arg 
            340                 345                 350         


Leu Thr Glu Gly Met Ser Gly Arg Glu Ile Ala Gln Leu Ala Val Ser 
        355                 360                 365             


Trp Gln Ala Thr Ala Tyr Ala Ser Lys Asp Gly Val Leu Thr Glu Ala 
    370                 375                 380                 


Met Met Asp Ala Cys Val Gln Asp Ala Val Gln Gln Tyr Arg Gln Lys 
385                 390                 395                 400 


Met Arg Trp Leu Lys Ala Glu Gly Pro Gly Arg Gly Val Glu His Pro 
                405                 410                 415     


Leu Ser Gly Val Gln Gly Glu Thr Leu Thr Ser Trp Ser Leu Ala Thr 
            420                 425                 430         


Asp Pro Ser Tyr Pro Cys Leu Ala Gly Pro Cys Thr Phe Arg Ile Cys 
        435                 440                 445             


Ser Trp Met Gly Thr Gly Leu Cys Pro Gly Pro Leu Ser Pro Arg Met 
    450                 455                 460                 


Ser Cys Gly Gly Gly Arg Pro Phe Cys Pro Pro Gly His Pro Leu Leu 
465                 470                 475                 480 


<210>  871
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATAD3C__Homo_sapiens__XP_011539310

<400>  871

Met Gln Arg Ala His Arg Arg Ala Asp Pro Ser Glu Leu Gln Cys Leu 
1               5                   10                  15      


Glu Ala Met Ser Lys Asp Ala Leu Asn Leu Ala Gln Met Gln Glu Gln 
            20                  25                  30          


Thr Leu Gln Leu Glu Gln Gln Ser Lys Leu Lys Gln Leu Val Asn Glu 
        35                  40                  45              


Asp Leu Arg Lys Gln Glu Glu Ser Val Gln Lys His His Gln Thr Phe 
    50                  55                  60                  


Leu Glu Ser Ile Arg Ala Ala Gly Thr Leu Phe Gly Glu Gly Phe Arg 
65                  70                  75                  80  


Ala Phe Val Thr Asp Arg Asp Lys Val Thr Ala Thr Val Ala Gly Leu 
                85                  90                  95      


Thr Leu Leu Ala Val Gly Val Tyr Ser Ala Lys Asn Ala Thr Ala Val 
            100                 105                 110         


Thr Gly Arg Tyr Ile Glu Ala Arg Leu Gly Lys Pro Ser Leu Val Arg 
        115                 120                 125             


Glu Thr Ser Arg Ile Thr Val Leu Glu Ala Leu Arg His Pro Ile Gln 
    130                 135                 140                 


Gln Val Ser Arg Arg Leu Leu Ser Arg Pro Gln Asp Val Leu Glu Gly 
145                 150                 155                 160 


Val Val Leu Ser Pro Ser Leu Glu Ala Arg Val Arg Asp Ile Ala Ile 
                165                 170                 175     


Met Thr Arg Asn Ile Lys Lys Asn Arg Gly Leu Tyr Arg His Ile Leu 
            180                 185                 190         


Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Phe Ala Lys Lys Leu 
        195                 200                 205             


Ala Leu His Ser Gly Met Asp Tyr Ala Ile Met Thr Gly Gly Asp Val 
    210                 215                 220                 


Ala Pro Met Gly Arg Glu Gly Val Thr Ala Met His Lys Leu Phe Asp 
225                 230                 235                 240 


Trp Ala Asn Thr Ser Arg Arg Gly Leu Leu Leu Phe Val Asp Glu Ala 
                245                 250                 255     


Asp Ala Phe Leu Arg Lys Arg Ala Thr Glu Lys Ile Ser Glu Asp Leu 
            260                 265                 270         


Arg Ala Thr Leu Asn Ala Phe Leu Tyr Arg Thr Gly Gln His Ser Asn 
        275                 280                 285             


Lys Phe Met Leu Ile Leu Ala Ser Cys His Pro Glu Gln Phe Asp Trp 
    290                 295                 300                 


Ala Ile Asn Ala Cys Ile Asp Val Met Val His Phe Asp Leu Pro Gly 
305                 310                 315                 320 


Gln Glu Glu Arg Ala Arg Leu Val Arg Met Tyr Leu Asn Glu Tyr Val 
                325                 330                 335     


Leu Lys Pro Ala Thr Glu Gly Lys Arg Arg Leu Lys Leu Ala Gln Phe 
            340                 345                 350         


Asp Tyr Gly Arg Lys Cys Leu Glu Ile Ala Arg Leu Thr Glu Gly Met 
        355                 360                 365             


Ser Cys Arg Lys Ile Ala Gln Leu Ala Val Ser Trp Gln Ala Thr Ala 
    370                 375                 380                 


Tyr Ala Ser Lys Asp Gly Val Leu Thr Glu Ala Met Met Asp Ala Cys 
385                 390                 395                 400 


Val Gln Asp Phe Val Gln Gln His Gln Gln Met Met Arg Trp Leu Lys 
                405                 410                 415     


Gly Glu Arg Pro Gly Pro Glu Asp Glu Gln Pro Ser Ser 
            420                 425                 


<210>  872
<211>  1844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATAD5__Homo_sapiens__NP_079133

<400>  872

Met Val Gly Val Leu Ala Met Ala Ala Ala Ala Ala Pro Pro Pro Val 
1               5                   10                  15      


Lys Asp Cys Glu Ile Glu Pro Cys Lys Lys Arg Lys Lys Asp Asp Asp 
            20                  25                  30          


Thr Ser Thr Cys Lys Thr Ile Thr Lys Tyr Leu Ser Pro Leu Gly Lys 
        35                  40                  45              


Thr Arg Asp Arg Val Phe Ala Pro Pro Lys Pro Ser Asn Ile Leu Asp 
    50                  55                  60                  


Tyr Phe Arg Lys Thr Ser Pro Thr Asn Glu Lys Thr Gln Leu Gly Lys 
65                  70                  75                  80  


Glu Cys Lys Ile Lys Ser Pro Glu Ser Val Pro Val Asp Ser Asn Lys 
                85                  90                  95      


Asp Cys Thr Thr Pro Leu Glu Met Phe Ser Asn Val Glu Phe Lys Lys 
            100                 105                 110         


Lys Arg Lys Arg Val Asn Leu Ser His Gln Leu Asn Asn Ile Lys Thr 
        115                 120                 125             


Glu Asn Glu Ala Pro Ile Glu Ile Ser Ser Asp Asp Ser Lys Glu Asp 
    130                 135                 140                 


Tyr Ser Leu Asn Asn Asp Phe Val Glu Ser Ser Thr Ser Val Leu Arg 
145                 150                 155                 160 


Tyr Lys Lys Gln Val Glu Val Leu Ala Glu Asn Ile Gln Asp Thr Lys 
                165                 170                 175     


Ser Gln Pro Asn Thr Met Thr Ser Leu Gln Asn Ser Lys Lys Val Asn 
            180                 185                 190         


Pro Lys Gln Gly Thr Thr Lys Asn Asp Phe Lys Lys Leu Arg Lys Arg 
        195                 200                 205             


Lys Cys Arg Asp Val Val Asp Leu Ser Glu Ser Leu Pro Leu Ala Glu 
    210                 215                 220                 


Glu Leu Asn Leu Leu Lys Lys Asp Gly Lys Asp Thr Lys Gln Met Glu 
225                 230                 235                 240 


Asn Thr Thr Ser His Ala Asn Ser Arg Asp Asn Val Thr Glu Ala Ala 
                245                 250                 255     


Gln Leu Asn Asp Ser Ile Ile Thr Val Ser Tyr Glu Glu Phe Leu Lys 
            260                 265                 270         


Ser His Lys Glu Asn Lys Val Glu Glu Ile Pro Asp Ser Thr Met Ser 
        275                 280                 285             


Ile Cys Val Pro Ser Glu Thr Val Asp Glu Ile Val Lys Ser Gly Tyr 
    290                 295                 300                 


Ile Ser Glu Ser Glu Asn Ser Glu Ile Ser Gln Gln Val Arg Phe Lys 
305                 310                 315                 320 


Thr Val Thr Val Leu Ala Gln Val His Pro Ile Pro Pro Lys Lys Thr 
                325                 330                 335     


Gly Lys Ile Pro Arg Ile Phe Leu Lys Gln Lys Gln Phe Glu Met Glu 
            340                 345                 350         


Asn Ser Leu Ser Asp Pro Glu Asn Glu Gln Thr Val Gln Lys Arg Lys 
        355                 360                 365             


Ser Asn Val Val Ile Gln Glu Glu Glu Leu Glu Leu Ala Val Leu Glu 
    370                 375                 380                 


Ala Gly Ser Ser Glu Ala Val Lys Pro Lys Cys Thr Leu Glu Glu Arg 
385                 390                 395                 400 


Gln Gln Phe Met Lys Ala Phe Arg Gln Pro Ala Ser Asp Ala Leu Lys 
                405                 410                 415     


Asn Gly Val Lys Lys Ser Ser Asp Lys Gln Lys Asp Leu Asn Glu Lys 
            420                 425                 430         


Cys Leu Tyr Glu Val Gly Arg Asp Asp Asn Ser Lys Lys Ile Met Glu 
        435                 440                 445             


Asn Ser Gly Ile Gln Met Val Ser Lys Asn Gly Asn Leu Gln Leu His 
    450                 455                 460                 


Thr Asp Lys Gly Ser Phe Leu Lys Glu Lys Asn Lys Lys Leu Lys Lys 
465                 470                 475                 480 


Lys Asn Lys Lys Thr Leu Asp Thr Gly Ala Ile Pro Gly Lys Asn Arg 
                485                 490                 495     


Glu Gly Asn Thr Gln Lys Lys Glu Thr Thr Phe Phe Leu Lys Glu Lys 
            500                 505                 510         


Gln Tyr Gln Asn Arg Met Ser Leu Arg Gln Arg Lys Thr Glu Phe Phe 
        515                 520                 525             


Lys Ser Ser Thr Leu Phe Asn Asn Glu Ser Leu Val Tyr Glu Asp Ile 
    530                 535                 540                 


Ala Asn Asp Asp Leu Leu Lys Val Ser Ser Leu Cys Asn Asn Asn Lys 
545                 550                 555                 560 


Leu Ser Arg Lys Thr Ser Ile Pro Val Lys Asp Ile Lys Leu Thr Gln 
                565                 570                 575     


Ser Lys Ala Glu Ser Glu Ala Ser Leu Leu Asn Val Ser Thr Pro Lys 
            580                 585                 590         


Ser Thr Arg Arg Ser Gly Arg Ile Ser Ser Thr Pro Thr Thr Glu Thr 
        595                 600                 605             


Ile Arg Gly Ile Asp Ser Asp Asp Val Gln Asp Asn Ser Gln Leu Lys 
    610                 615                 620                 


Ala Ser Thr Gln Lys Ala Ala Asn Leu Ser Glu Lys His Ser Leu Tyr 
625                 630                 635                 640 


Thr Ala Glu Leu Ile Thr Val Pro Phe Asp Ser Glu Ser Pro Ile Arg 
                645                 650                 655     


Met Lys Phe Thr Arg Ile Ser Thr Pro Lys Lys Ser Lys Lys Lys Ser 
            660                 665                 670         


Asn Lys Arg Ser Glu Lys Ser Glu Ala Thr Asp Gly Gly Phe Thr Ser 
        675                 680                 685             


Gln Ile Arg Lys Ala Ser Asn Thr Ser Lys Asn Ile Ser Lys Ala Lys 
    690                 695                 700                 


Gln Leu Ile Glu Lys Ala Lys Ala Leu His Ile Ser Arg Ser Lys Val 
705                 710                 715                 720 


Thr Glu Glu Ile Ala Ile Pro Leu Arg Arg Ser Ser Arg His Gln Thr 
                725                 730                 735     


Leu Pro Glu Arg Lys Lys Leu Ser Glu Thr Glu Asp Ser Val Ile Ile 
            740                 745                 750         


Ile Asp Ser Ser Pro Thr Ala Leu Lys His Pro Glu Lys Asn Gln Lys 
        755                 760                 765             


Lys Leu Gln Cys Leu Asn Asp Val Leu Gly Lys Lys Leu Asn Thr Ser 
    770                 775                 780                 


Thr Lys Asn Val Pro Gly Lys Met Lys Val Ala Pro Leu Phe Leu Val 
785                 790                 795                 800 


Arg Lys Ala Gln Lys Ala Ala Asp Pro Val Pro Ser Phe Asp Glu Ser 
                805                 810                 815     


Ser Gln Asp Thr Ser Glu Lys Ser Gln Asp Cys Asp Val Gln Cys Lys 
            820                 825                 830         


Ala Lys Arg Asp Phe Leu Met Ser Gly Leu Pro Asp Leu Leu Lys Arg 
        835                 840                 845             


Gln Ile Ala Lys Lys Ala Ala Ala Leu Asp Val Tyr Asn Ala Val Ser 
    850                 855                 860                 


Thr Ser Phe Gln Arg Val Val His Val Gln Gln Lys Asp Asp Gly Cys 
865                 870                 875                 880 


Cys Leu Trp His Leu Lys Pro Pro Ser Cys Pro Leu Leu Thr Lys Phe 
                885                 890                 895     


Lys Glu Leu Asn Thr Lys Val Ile Asp Leu Ser Lys Cys Gly Ile Ala 
            900                 905                 910         


Leu Gly Glu Phe Ser Thr Leu Asn Ser Lys Leu Lys Ser Gly Asn Ser 
        915                 920                 925             


Ala Ala Val Phe Met Arg Thr Arg Lys Glu Phe Thr Glu Glu Val Arg 
    930                 935                 940                 


Asn Leu Leu Leu Glu Glu Ile Arg Trp Ser Asn Pro Glu Phe Ser Leu 
945                 950                 955                 960 


Lys Lys Tyr Phe Pro Leu Leu Leu Lys Lys Gln Ile Glu His Gln Val 
                965                 970                 975     


Leu Ser Ser Glu Cys His Ser Lys Gln Glu Leu Glu Ala Asp Val Ser 
            980                 985                 990         


His Lys Glu Thr Lys Arg Lys Leu  Val Glu Ala Glu Asn  Ser Lys Ser 
        995                 1000                 1005             


Lys Arg  Lys Lys Pro Asn Glu  Tyr Ser Lys Asn Leu  Glu Lys Thr 
    1010                 1015                 1020             


Asn Arg  Lys Ser Glu Glu Leu  Ser Lys Arg Asn Asn  Ser Ser Gly 
    1025                 1030                 1035             


Ile Lys  Leu Asp Ser Ser Lys  Asp Ser Gly Thr Glu  Asp Met Leu 
    1040                 1045                 1050             


Trp Thr  Glu Lys Tyr Gln Pro  Gln Thr Ala Ser Glu  Leu Ile Gly 
    1055                 1060                 1065             


Asn Glu  Leu Ala Ile Lys Lys  Leu His Ser Trp Leu  Lys Asp Trp 
    1070                 1075                 1080             


Lys Arg  Arg Ala Glu Leu Glu  Glu Arg Gln Asn Leu  Lys Gly Lys 
    1085                 1090                 1095             


Arg Asp  Glu Lys His Glu Asp  Phe Ser Gly Gly Ile  Asp Phe Lys 
    1100                 1105                 1110             


Gly Ser  Ser Asp Asp Glu Glu  Glu Ser Arg Leu Cys  Asn Thr Val 
    1115                 1120                 1125             


Leu Ile  Thr Gly Pro Thr Gly  Val Gly Lys Thr Ala  Ala Val Tyr 
    1130                 1135                 1140             


Ala Cys  Ala Gln Glu Leu Gly  Phe Lys Ile Phe Glu  Val Asn Ala 
    1145                 1150                 1155             


Ser Ser  Gln Arg Ser Gly Arg  Gln Ile Leu Ser Gln  Leu Lys Glu 
    1160                 1165                 1170             


Ala Thr  Gln Ser His Gln Val  Asp Lys Gln Gly Val  Asn Ser Gln 
    1175                 1180                 1185             


Lys Pro  Cys Phe Phe Asn Ser  Tyr Tyr Ile Gly Lys  Ser Pro Lys 
    1190                 1195                 1200             


Lys Ile  Ser Ser Pro Lys Lys  Val Val Thr Ser Pro  Arg Lys Val 
    1205                 1210                 1215             


Pro Pro  Pro Ser Pro Lys Ser  Ser Gly Pro Lys Arg  Ala Leu Pro 
    1220                 1225                 1230             


Pro Lys  Thr Leu Ala Asn Tyr  Phe Lys Val Ser Pro  Lys Pro Lys 
    1235                 1240                 1245             


Asn Asn  Glu Glu Ile Gly Met  Leu Leu Glu Asn Asn  Lys Gly Ile 
    1250                 1255                 1260             


Lys Asn  Ser Phe Glu Gln Lys  Gln Ile Thr Gln Thr  Lys Ser Thr 
    1265                 1270                 1275             


Asn Ala  Thr Asn Ser Asn Val  Lys Asp Val Gly Ala  Glu Glu Pro 
    1280                 1285                 1290             


Ser Arg  Lys Asn Ala Thr Ser  Leu Ile Leu Phe Glu  Glu Val Asp 
    1295                 1300                 1305             


Val Ile  Phe Asp Glu Asp Ala  Gly Phe Leu Asn Ala  Ile Lys Thr 
    1310                 1315                 1320             


Phe Met  Ala Thr Thr Lys Arg  Pro Val Ile Leu Thr  Thr Ser Asp 
    1325                 1330                 1335             


Pro Thr  Phe Ser Leu Met Phe  Asp Gly Cys Phe Glu  Glu Ile Lys 
    1340                 1345                 1350             


Phe Ser  Thr Pro Ser Leu Leu  Asn Val Ala Ser Tyr  Leu Gln Met 
    1355                 1360                 1365             


Ile Cys  Leu Thr Glu Asn Phe  Arg Thr Asp Val Lys  Asp Phe Val 
    1370                 1375                 1380             


Thr Leu  Leu Thr Ala Asn Thr  Cys Asp Ile Arg Lys  Ser Ile Leu 
    1385                 1390                 1395             


Tyr Leu  Gln Phe Trp Ile Arg  Ser Gly Gly Gly Val  Leu Glu Glu 
    1400                 1405                 1410             


Arg Pro  Leu Thr Leu Tyr Arg  Gly Asn Ser Arg Asn  Val Gln Leu 
    1415                 1420                 1425             


Val Cys  Ser Glu His Gly Leu  Asp Asn Lys Ile Tyr  Pro Lys Asn 
    1430                 1435                 1440             


Thr Lys  Lys Lys Arg Val Asp  Leu Pro Lys Cys Asp  Ser Gly Cys 
    1445                 1450                 1455             


Ala Glu  Thr Leu Phe Gly Leu  Lys Asn Ile Phe Ser  Pro Ser Glu 
    1460                 1465                 1470             


Asp Leu  Phe Ser Phe Leu Lys  His Lys Ile Thr Met  Lys Glu Glu 
    1475                 1480                 1485             


Trp His  Lys Phe Ile Gln Leu  Leu Thr Glu Phe Gln  Met Arg Asn 
    1490                 1495                 1500             


Val Asp  Phe Leu Tyr Ser Asn  Leu Glu Phe Ile Leu  Pro Leu Pro 
    1505                 1510                 1515             


Val Asp  Thr Ile Pro Glu Thr  Lys Asn Phe Cys Gly  Pro Ser Val 
    1520                 1525                 1530             


Thr Val  Asp Ala Ser Ala Ala  Thr Lys Ser Met Asn  Cys Leu Ala 
    1535                 1540                 1545             


Arg Lys  His Ser Glu Arg Glu  Gln Pro Leu Lys Lys  Ser Gln Lys 
    1550                 1555                 1560             


Lys Lys  Gln Lys Lys Thr Leu  Val Ile Leu Asp Asp  Ser Asp Leu 
    1565                 1570                 1575             


Phe Asp  Thr Asp Leu Asp Phe  Pro Asp Gln Ser Ile  Ser Leu Ser 
    1580                 1585                 1590             


Ser Val  Ser Ser Ser Ser Asn  Ala Glu Glu Ser Lys  Thr Gly Asp 
    1595                 1600                 1605             


Glu Glu  Ser Lys Ala Arg Asp  Lys Gly Asn Asn Pro  Glu Thr Lys 
    1610                 1615                 1620             


Lys Ser  Ile Pro Cys Pro Pro  Lys Thr Thr Ala Gly  Lys Lys Cys 
    1625                 1630                 1635             


Ser Ala  Leu Val Ser His Cys  Leu Asn Ser Leu Ser  Glu Phe Met 
    1640                 1645                 1650             


Asp Asn  Met Ser Phe Leu Asp  Ala Leu Leu Thr Asp  Val Arg Glu 
    1655                 1660                 1665             


Gln Asn  Lys Tyr Gly Arg Asn  Asp Phe Ser Trp Thr  Asn Gly Lys 
    1670                 1675                 1680             


Val Thr  Ser Gly Leu Cys Asp  Glu Phe Ser Leu Glu  Ser Asn Asp 
    1685                 1690                 1695             


Gly Trp  Thr Ser Gln Ser Ser  Gly Glu Leu Lys Ala  Ala Ala Glu 
    1700                 1705                 1710             


Ala Leu  Ser Phe Thr Lys Cys  Ser Ser Ala Ile Ser  Lys Ala Leu 
    1715                 1720                 1725             


Glu Thr  Leu Asn Ser Cys Lys  Lys Leu Gly Arg Asp  Pro Thr Asn 
    1730                 1735                 1740             


Asp Leu  Thr Phe Tyr Val Ser  Gln Lys Arg Asn Asn  Val Tyr Phe 
    1745                 1750                 1755             


Ser Gln  Ser Ala Ala Asn Leu  Asp Asn Ala Trp Lys  Arg Ile Ser 
    1760                 1765                 1770             


Val Ile  Lys Ser Val Phe Ser  Ser Arg Ser Leu Leu  Tyr Val Gly 
    1775                 1780                 1785             


Asn Arg  Gln Ala Ser Ile Ile  Glu Tyr Leu Pro Thr  Leu Arg Asn 
    1790                 1795                 1800             


Ile Cys  Lys Thr Glu Lys Leu  Lys Glu Gln Gly Lys  Ser Lys Arg 
    1805                 1810                 1815             


Arg Phe  Leu His Tyr Phe Glu  Gly Ile His Leu Asp  Ile Pro Lys 
    1820                 1825                 1830             


Glu Thr  Val Asn Thr Leu Ala  Ala Asp Phe Pro 
    1835                 1840                 


<210>  873
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATAT1__Homo_sapiens__NP_001026892

<400>  873

Met Trp Leu Thr Trp Pro Phe Cys Phe Leu Thr Ile Thr Leu Arg Glu 
1               5                   10                  15      


Glu Gly Val Cys His Leu Glu Ser Val Asp Leu Gln Gln Gln Ile Met 
            20                  25                  30          


Thr Ile Ile Asp Glu Leu Gly Lys Ala Ser Ala Lys Ala Gln Asn Leu 
        35                  40                  45              


Ser Ala Pro Ile Thr Ser Ala Ser Arg Met Gln Ser Asn Arg His Val 
    50                  55                  60                  


Val Tyr Ile Leu Lys Asp Ser Ser Ala Arg Pro Ala Gly Lys Gly Ala 
65                  70                  75                  80  


Ile Ile Gly Phe Ile Lys Val Gly Tyr Lys Lys Leu Phe Val Leu Asp 
                85                  90                  95      


Asp Arg Glu Ala His Asn Glu Val Glu Pro Leu Cys Ile Leu Asp Phe 
            100                 105                 110         


Tyr Ile His Glu Ser Val Gln Arg His Gly His Gly Arg Glu Leu Phe 
        115                 120                 125             


Gln Tyr Met Leu Gln Lys Glu Arg Val Glu Pro His Gln Leu Ala Ile 
    130                 135                 140                 


Asp Arg Pro Ser Gln Lys Leu Leu Lys Phe Leu Asn Lys His Tyr Asn 
145                 150                 155                 160 


Leu Glu Thr Thr Val Pro Gln Val Asn Asn Phe Val Ile Phe Glu Gly 
                165                 170                 175     


Phe Phe Ala His Gln His Arg Pro Pro Ala Pro Ser Leu Arg Ala Thr 
            180                 185                 190         


Arg His Ser Arg Ala Ala Ala Val Asp Pro Thr Pro Ala Ala Pro Ala 
        195                 200                 205             


Arg Lys Leu Pro Pro Lys Arg Ala Glu Gly Asp Ile Lys Pro Tyr Ser 
    210                 215                 220                 


Ser Ser Asp Arg Glu Phe Leu Lys Val Ala Val Glu Pro Pro Trp Pro 
225                 230                 235                 240 


Leu Asn Arg Ala Pro Arg Arg Ala Thr Pro Pro Ala His Pro Pro Pro 
                245                 250                 255     


Arg Ser Ser Ser Leu Gly Asn Ser Pro Glu Arg Gly Pro Leu Arg Pro 
            260                 265                 270         


Phe Val Pro Glu Gln Glu Leu Leu Arg Ser Leu Arg Leu Cys Pro Pro 
        275                 280                 285             


His Pro Thr Ala Arg Leu Leu Leu Ala Ala Asp Pro Gly Gly Ser Pro 
    290                 295                 300                 


Ala Gln Arg Arg Arg Thr Arg Gly Thr Pro Pro Gly Leu Val Ala Gln 
305                 310                 315                 320 


Ser Cys Cys Tyr Ser Arg His Gly Gly Val Asn Ser Ser Ser Pro Asn 
                325                 330                 335     


Thr Gly Asn Gln Asp Ser Lys Gln Gly Glu Gln Glu Thr Lys Asn Arg 
            340                 345                 350         


Ser Ala Ser Glu Glu Gln Ala Leu Ser Gln Asp Gly Ser Gly Glu Lys 
        355                 360                 365             


Pro Met His Thr Ala Pro Pro Gln Ala Pro Ala Pro Pro Ala Gln Ser 
    370                 375                 380                 


Trp Thr Val Gly Gly Asp Ile Leu Asn Ala Arg Phe Ile Arg Asn Leu 
385                 390                 395                 400 


Gln Glu Arg Arg Ser Thr Arg Pro Trp 
                405                 


<210>  874
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATCAY__Homo_sapiens__NP_149053

<400>  874

Met Gly Thr Thr Glu Ala Thr Leu Arg Met Glu Asn Val Asp Val Lys 
1               5                   10                  15      


Glu Glu Trp Gln Asp Glu Asp Leu Pro Arg Pro Leu Pro Glu Glu Thr 
            20                  25                  30          


Gly Val Glu Leu Leu Gly Ser Pro Val Glu Asp Thr Ser Ser Pro Pro 
        35                  40                  45              


Asn Thr Leu Asn Phe Asn Gly Ala His Arg Lys Arg Lys Thr Leu Val 
    50                  55                  60                  


Ala Pro Glu Ile Asn Ile Ser Leu Asp Gln Ser Glu Gly Ser Leu Leu 
65                  70                  75                  80  


Ser Asp Asp Phe Leu Asp Thr Pro Asp Asp Leu Asp Ile Asn Val Asp 
                85                  90                  95      


Asp Ile Glu Thr Pro Asp Glu Thr Asp Ser Leu Glu Phe Leu Gly Asn 
            100                 105                 110         


Gly Asn Glu Leu Glu Trp Glu Asp Asp Thr Pro Val Ala Thr Ala Lys 
        115                 120                 125             


Asn Met Pro Gly Asp Ser Ala Asp Leu Phe Gly Asp Gly Thr Thr Glu 
    130                 135                 140                 


Asp Gly Ser Ala Ala Asn Gly Arg Leu Trp Arg Thr Val Ile Ile Gly 
145                 150                 155                 160 


Glu Gln Glu His Arg Ile Asp Leu His Met Ile Arg Pro Tyr Met Lys 
                165                 170                 175     


Val Val Thr His Gly Gly Tyr Tyr Gly Glu Gly Leu Asn Ala Ile Ile 
            180                 185                 190         


Val Phe Ala Ala Cys Phe Leu Pro Asp Ser Ser Leu Pro Asp Tyr His 
        195                 200                 205             


Tyr Ile Met Glu Asn Leu Phe Leu Tyr Val Ile Ser Ser Leu Glu Leu 
    210                 215                 220                 


Leu Val Ala Glu Asp Tyr Met Ile Val Tyr Leu Asn Gly Ala Thr Pro 
225                 230                 235                 240 


Arg Arg Arg Met Pro Gly Ile Gly Trp Leu Lys Lys Cys Tyr Gln Met 
                245                 250                 255     


Ile Asp Arg Arg Leu Arg Lys Asn Leu Lys Ser Leu Ile Ile Val His 
            260                 265                 270         


Pro Ser Trp Phe Ile Arg Thr Val Leu Ala Ile Ser Arg Pro Phe Ile 
        275                 280                 285             


Ser Val Lys Phe Ile Asn Lys Ile Gln Tyr Val His Ser Leu Glu Asp 
    290                 295                 300                 


Leu Glu Gln Leu Ile Pro Met Glu His Val Gln Ile Pro Asp Cys Val 
305                 310                 315                 320 


Leu Gln Tyr Glu Glu Glu Arg Leu Lys Ala Arg Arg Glu Ser Ala Arg 
                325                 330                 335     


Pro Gln Pro Glu Phe Val Leu Pro Arg Ser Glu Glu Lys Pro Glu Val 
            340                 345                 350         


Ala Pro Val Glu Asn Arg Ser Ala Leu Val Ser Glu Asp Gln Glu Thr 
        355                 360                 365             


Ser Met Ser 
    370     


<210>  875
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATE1__Homo_sapiens__NP_001001976

<400>  875

Met Ala Phe Trp Ala Gly Gly Ser Pro Ser Val Val Asp Tyr Phe Pro 
1               5                   10                  15      


Ser Glu Asp Phe Tyr Arg Cys Gly Tyr Cys Lys Asn Glu Ser Gly Ser 
            20                  25                  30          


Arg Ser Asn Gly Met Trp Ala His Ser Met Thr Val Gln Asp Tyr Gln 
        35                  40                  45              


Asp Leu Ile Asp Arg Gly Trp Arg Arg Ser Gly Lys Tyr Val Tyr Lys 
    50                  55                  60                  


Pro Val Met Asn Gln Thr Cys Cys Pro Gln Tyr Thr Ile Arg Cys Arg 
65                  70                  75                  80  


Pro Leu Gln Phe Gln Pro Ser Lys Ser His Lys Lys Val Leu Lys Lys 
                85                  90                  95      


Met Leu Lys Phe Leu Ala Lys Gly Glu Val Pro Lys Gly Ser Cys Glu 
            100                 105                 110         


Asp Glu Pro Met Asp Ser Thr Met Asp Asp Ala Val Ala Gly Asp Phe 
        115                 120                 125             


Ala Leu Ile Asn Lys Leu Asp Ile Gln Cys Asp Leu Lys Thr Leu Ser 
    130                 135                 140                 


Asp Asp Ile Lys Glu Ser Leu Glu Ser Glu Gly Lys Asn Ser Lys Lys 
145                 150                 155                 160 


Glu Glu Pro Gln Glu Leu Leu Gln Ser Gln Asp Phe Val Gly Glu Lys 
                165                 170                 175     


Leu Gly Ser Gly Glu Pro Ser His Ser Val Lys Val His Thr Val Pro 
            180                 185                 190         


Lys Pro Gly Lys Gly Ala Asp Leu Ser Lys Pro Pro Cys Arg Lys Ala 
        195                 200                 205             


Lys Glu Ile Arg Lys Glu Arg Lys Arg Leu Lys Leu Met Gln Gln Asn 
    210                 215                 220                 


Pro Ala Gly Glu Leu Glu Gly Phe Gln Ala Gln Gly His Pro Pro Ser 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Ala Lys Ser Asn Gln Pro Lys Ser Leu Glu Asp 
                245                 250                 255     


Leu Ile Phe Glu Ser Leu Pro Glu Asn Ala Ser His Lys Leu Glu Val 
            260                 265                 270         


Arg Val Val Arg Ser Ser Pro Pro Ser Ser Gln Phe Lys Ala Thr Leu 
        275                 280                 285             


Leu Glu Ser Tyr Gln Val Tyr Lys Arg Tyr Gln Met Val Ile His Lys 
    290                 295                 300                 


Asn Pro Pro Asp Thr Pro Thr Glu Ser Gln Phe Thr Arg Phe Leu Cys 
305                 310                 315                 320 


Ser Ser Pro Leu Glu Ala Glu Thr Pro Pro Asn Gly Pro Asp Cys Gly 
                325                 330                 335     


Tyr Gly Ser Phe His Gln Gln Tyr Trp Leu Asp Gly Lys Ile Ile Ala 
            340                 345                 350         


Val Gly Val Ile Asp Ile Leu Pro Asn Cys Val Ser Ser Val Tyr Leu 
        355                 360                 365             


Tyr Tyr Asp Pro Asp Tyr Ser Phe Leu Ser Leu Gly Val Tyr Ser Ala 
    370                 375                 380                 


Leu Arg Glu Ile Ala Phe Thr Arg Gln Leu His Glu Lys Thr Ser Gln 
385                 390                 395                 400 


Leu Ser Tyr Tyr Tyr Met Gly Phe Tyr Ile His Ser Cys Pro Lys Met 
                405                 410                 415     


Lys Tyr Lys Gly Gln Tyr Arg Pro Ser Asp Leu Leu Cys Pro Glu Thr 
            420                 425                 430         


Tyr Val Trp Val Pro Ile Glu Gln Cys Leu Pro Ser Leu Glu Asn Ser 
        435                 440                 445             


Lys Tyr Cys Arg Phe Asn Gln Asp Pro Glu Ala Val Asp Glu Asp Arg 
    450                 455                 460                 


Ser Thr Glu Pro Asp Arg Leu Gln Val Phe His Lys Arg Ala Ile Met 
465                 470                 475                 480 


Pro Tyr Gly Val Tyr Lys Lys Gln Gln Lys Asp Pro Ser Glu Glu Ala 
                485                 490                 495     


Ala Val Leu Gln Tyr Ala Ser Leu Val Gly Gln Lys Cys Ser Glu Arg 
            500                 505                 510         


Met Leu Leu Phe Arg Asn 
        515             


<210>  876
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF1__Homo_sapiens__XP_011536689

<400>  876

Met Glu Asp Ser His Lys Ser Thr Thr Ser Glu Thr Ala Pro Gln Pro 
1               5                   10                  15      


Gly Ser Ala Val Gln Gly Ala His Ile Ser His Ile Ala Gln Gln Val 
            20                  25                  30          


Ser Ser Leu Ser Glu Ser Glu Glu Ser Gln Asp Ser Ser Asp Ser Ile 
        35                  40                  45              


Gly Ser Ser Gln Lys Ala His Gly Ile Leu Ala Arg Arg Pro Ser Tyr 
    50                  55                  60                  


Arg Lys Ile Leu Lys Asp Leu Ser Ser Glu Asp Thr Arg Gly Arg Lys 
65                  70                  75                  80  


Gly Asp Gly Glu Asn Ser Gly Val Ser Ala Ala Val Thr Ser Met Ser 
                85                  90                  95      


Val Pro Thr Pro Ile Tyr Gln Thr Ser Ser Gly Gln Tyr Ile Ala Ile 
            100                 105                 110         


Ala Pro Asn Gly Ala Leu Gln Leu Ala Ser Pro Gly Thr Asp Gly Val 
        115                 120                 125             


Gln Gly Leu Gln Thr Leu Thr Met Thr Asn Ser Gly Ser Thr Gln Gln 
    130                 135                 140                 


Gly Thr Thr Ile Leu Gln Tyr Ala Gln Thr Ser Asp Gly Gln Gln Ile 
145                 150                 155                 160 


Leu Val Pro Ser Asn Gln Val Val Val Gln Thr Ala Ser Gly Asp Met 
                165                 170                 175     


Gln Thr Tyr Gln Ile Arg Thr Thr Pro Ser Ala Thr Ser Leu Pro Gln 
            180                 185                 190         


Thr Val Val Met Thr Ser Pro Val Thr Leu Thr Ser Gln Thr Thr Lys 
        195                 200                 205             


Thr Asp Asp Pro Gln Leu Lys Arg Glu Ile Arg Leu Met Lys Asn Arg 
    210                 215                 220                 


Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys 
225                 230                 235                 240 


Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile 
                245                 250                 255     


Glu Glu Leu Lys Thr Leu Lys Asp Leu Tyr Ser Asn Lys Ser Val 
            260                 265                 270     


<210>  877
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF2__Homo_sapiens__NP_001243019

<400>  877

Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu 
1               5                   10                  15      


Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Thr Ala Pro Gly Cys 
            20                  25                  30          


Gly Gln Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys 
        35                  40                  45              


His Glu Met Thr Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile 
    50                  55                  60                  


Val Ala Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu 
65                  70                  75                  80  


Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe 
                85                  90                  95      


Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser 
            100                 105                 110         


Pro Leu Ala Thr Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val 
        115                 120                 125             


Val Glu Thr Thr His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Thr 
    130                 135                 140                 


Thr Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Thr Ala Gln Pro Thr 
145                 150                 155                 160 


Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu 
                165                 170                 175     


Thr Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro 
            180                 185                 190         


Thr Ser Ser Thr Val Ile Thr Gln Ala Pro Ser Ser Asn Arg Pro Ile 
        195                 200                 205             


Val Pro Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly 
    210                 215                 220                 


Gln Thr Met Pro Val Ala Ile Pro Ala Ser Ile Thr Ser Ser Asn Val 
225                 230                 235                 240 


His Val Pro Ala Ala Val Pro Leu Val Arg Pro Val Thr Met Val Pro 
                245                 250                 255     


Ser Val Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser 
            260                 265                 270         


Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Thr Gln Gln His Pro Pro 
        275                 280                 285             


Val Thr Asn Gly Asp Thr Val Lys Gly His Gly Ser Gly Leu Val Arg 
    290                 295                 300                 


Thr Gln Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Thr 
305                 310                 315                 320 


Ser Thr Thr Glu Thr Pro Ala Ser Pro Ala His Thr Thr Pro Gln Thr 
                325                 330                 335     


Gln Ser Thr Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp 
            340                 345                 350         


Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg 
        355                 360                 365             


Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala 
    370                 375                 380                 


Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Thr Leu 
385                 390                 395                 400 


Leu Arg Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys 
                405                 410                 415     


Asp Cys Pro Val Thr Ala Met Gln Lys Lys Ser Gly Tyr His Thr Ala 
            420                 425                 430         


Asp Lys Asp Asp Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His 
        435                 440                 445             


Thr Glu Ala Ile Gln His Ser Ser Val Ser Thr Ser Asn Gly Val Ser 
    450                 455                 460                 


Ser Thr Ser Lys Ala Glu Ala Val Ala Thr Ser Val Leu Thr Gln Met 
465                 470                 475                 480 


Ala Asp Gln Ser Thr Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro 
                485                 490                 495     


Ser Ser Gln Ser Gln Pro Ser Gly Ser 
            500                 505 


<210>  878
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF3__Homo_sapiens__NP_001035709

<400>  878

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Leu Pro Arg Pro Phe Trp Val Gln Lys Thr Cys Ile 
        115                 120                 125             


Trp Ala Val Asp Ser Cys Lys 
    130                 135 


<210>  879
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF4__Homo_sapiens__NP_001666

<400>  879

Met Thr Glu Met Ser Phe Leu Ser Ser Glu Val Leu Val Gly Asp Leu 
1               5                   10                  15      


Met Ser Pro Phe Asp Gln Ser Gly Leu Gly Ala Glu Glu Ser Leu Gly 
            20                  25                  30          


Leu Leu Asp Asp Tyr Leu Glu Val Ala Lys His Phe Lys Pro His Gly 
        35                  40                  45              


Phe Ser Ser Asp Lys Ala Lys Ala Gly Ser Ser Glu Trp Leu Ala Val 
    50                  55                  60                  


Asp Gly Leu Val Ser Pro Ser Asn Asn Ser Lys Glu Asp Ala Phe Ser 
65                  70                  75                  80  


Gly Thr Asp Trp Met Leu Glu Lys Met Asp Leu Lys Glu Phe Asp Leu 
                85                  90                  95      


Asp Ala Leu Leu Gly Ile Asp Asp Leu Glu Thr Met Pro Asp Asp Leu 
            100                 105                 110         


Leu Thr Thr Leu Asp Asp Thr Cys Asp Leu Phe Ala Pro Leu Val Gln 
        115                 120                 125             


Glu Thr Asn Lys Gln Pro Pro Gln Thr Val Asn Pro Ile Gly His Leu 
    130                 135                 140                 


Pro Glu Ser Leu Thr Lys Pro Asp Gln Val Ala Pro Phe Thr Phe Leu 
145                 150                 155                 160 


Gln Pro Leu Pro Leu Ser Pro Gly Val Leu Ser Ser Thr Pro Asp His 
                165                 170                 175     


Ser Phe Ser Leu Glu Leu Gly Ser Glu Val Asp Ile Thr Glu Gly Asp 
            180                 185                 190         


Arg Lys Pro Asp Tyr Thr Ala Tyr Val Ala Met Ile Pro Gln Cys Ile 
        195                 200                 205             


Lys Glu Glu Asp Thr Pro Ser Asp Asn Asp Ser Gly Ile Cys Met Ser 
    210                 215                 220                 


Pro Glu Ser Tyr Leu Gly Ser Pro Gln His Ser Pro Ser Thr Arg Gly 
225                 230                 235                 240 


Ser Pro Asn Arg Ser Leu Pro Ser Pro Gly Val Leu Cys Gly Ser Ala 
                245                 250                 255     


Arg Pro Lys Pro Tyr Asp Pro Pro Gly Glu Lys Met Val Ala Ala Lys 
            260                 265                 270         


Val Lys Gly Glu Lys Leu Asp Lys Lys Leu Lys Lys Met Glu Gln Asn 
        275                 280                 285             


Lys Thr Ala Ala Thr Arg Tyr Arg Gln Lys Lys Arg Ala Glu Gln Glu 
    290                 295                 300                 


Ala Leu Thr Gly Glu Cys Lys Glu Leu Glu Lys Lys Asn Glu Ala Leu 
305                 310                 315                 320 


Lys Glu Arg Ala Asp Ser Leu Ala Lys Glu Ile Gln Tyr Leu Lys Asp 
                325                 330                 335     


Leu Ile Glu Glu Val Arg Lys Ala Arg Gly Lys Lys Arg Val Pro 
            340                 345                 350     


<210>  880
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF5__Homo_sapiens__NP_001277675

<400>  880

Met Ser Leu Leu Ala Thr Leu Gly Leu Glu Leu Asp Arg Ala Leu Leu 
1               5                   10                  15      


Pro Ala Ser Gly Leu Gly Trp Leu Val Asp Tyr Gly Lys Leu Pro Pro 
            20                  25                  30          


Ala Pro Ala Pro Leu Ala Pro Tyr Glu Val Leu Gly Gly Ala Leu Glu 
        35                  40                  45              


Gly Gly Leu Pro Val Gly Gly Glu Pro Leu Ala Gly Asp Gly Phe Ser 
    50                  55                  60                  


Asp Trp Met Thr Glu Arg Val Asp Phe Thr Ala Leu Leu Pro Leu Glu 
65                  70                  75                  80  


Pro Pro Leu Pro Pro Gly Thr Leu Pro Gln Pro Ser Pro Thr Pro Pro 
                85                  90                  95      


Asp Leu Glu Ala Met Ala Ser Leu Leu Lys Lys Glu Leu Glu Gln Met 
            100                 105                 110         


Glu Asp Phe Phe Leu Asp Ala Pro Pro Leu Pro Pro Pro Ser Pro Pro 
        115                 120                 125             


Pro Leu Pro Pro Pro Pro Leu Pro Pro Ala Pro Ser Leu Pro Leu Ser 
    130                 135                 140                 


Leu Pro Ser Phe Asp Leu Pro Gln Pro Pro Val Leu Asp Thr Leu Asp 
145                 150                 155                 160 


Leu Leu Ala Ile Tyr Cys Arg Asn Glu Ala Gly Gln Glu Glu Val Gly 
                165                 170                 175     


Met Pro Pro Leu Pro Pro Pro Gln Gln Pro Pro Pro Pro Ser Pro Pro 
            180                 185                 190         


Gln Pro Ser Arg Leu Ala Pro Tyr Pro His Pro Ala Thr Thr Arg Gly 
        195                 200                 205             


Asp Arg Lys Gln Lys Lys Arg Asp Gln Asn Lys Ser Ala Ala Leu Arg 
    210                 215                 220                 


Tyr Arg Gln Arg Lys Arg Ala Glu Gly Glu Ala Leu Glu Gly Glu Cys 
225                 230                 235                 240 


Gln Gly Leu Glu Ala Arg Asn Arg Glu Leu Lys Glu Arg Ala Glu Ser 
                245                 250                 255     


Val Glu Arg Glu Ile Gln Tyr Val Lys Asp Leu Leu Ile Glu Val Tyr 
            260                 265                 270         


Lys Ala Arg Ser Gln Arg Thr Arg Ser Cys 
        275                 280         


<210>  881
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF6B__Homo_sapiens__NP_001129625

<400>  881

Met Ala Glu Leu Met Leu Leu Ser Glu Ile Ala Asp Pro Thr Arg Phe 
1               5                   10                  15      


Phe Thr Asp Asn Leu Leu Ser Pro Glu Asp Trp Asp Ser Thr Leu Tyr 
            20                  25                  30          


Ser Gly Leu Asp Glu Val Ala Glu Glu Gln Thr Gln Leu Phe Arg Cys 
        35                  40                  45              


Pro Glu Gln Asp Val Pro Phe Asp Gly Ser Ser Leu Asp Val Gly Met 
    50                  55                  60                  


Asp Val Ser Pro Ser Glu Pro Pro Trp Glu Leu Leu Pro Ile Phe Pro 
65                  70                  75                  80  


Asp Leu Gln Val Lys Ser Glu Pro Ser Ser Pro Cys Ser Ser Ser Ser 
                85                  90                  95      


Leu Ser Ser Glu Ser Ser Arg Leu Ser Thr Glu Pro Ser Ser Glu Ala 
            100                 105                 110         


Leu Gly Val Gly Glu Val Leu His Val Lys Thr Glu Ser Leu Ala Pro 
        115                 120                 125             


Pro Leu Cys Leu Leu Gly Asp Asp Pro Thr Ser Ser Phe Glu Thr Val 
    130                 135                 140                 


Gln Ile Asn Val Ile Pro Thr Ser Asp Asp Ser Ser Asp Val Gln Thr 
145                 150                 155                 160 


Lys Ile Glu Pro Val Ser Pro Cys Ser Ser Val Asn Ser Glu Ala Ser 
                165                 170                 175     


Leu Leu Ser Ala Asp Ser Ser Ser Gln Ala Phe Ile Gly Glu Glu Val 
            180                 185                 190         


Leu Glu Val Lys Thr Glu Ser Leu Ser Pro Ser Gly Cys Leu Leu Trp 
        195                 200                 205             


Asp Val Pro Ala Pro Ser Leu Gly Ala Val Gln Ile Ser Met Gly Pro 
    210                 215                 220                 


Ser Leu Asp Gly Ser Ser Gly Lys Ala Leu Pro Thr Arg Lys Pro Pro 
225                 230                 235                 240 


Leu Gln Pro Lys Pro Val Val Leu Thr Thr Val Pro Met Pro Ser Arg 
                245                 250                 255     


Ala Val Pro Pro Ser Thr Thr Val Leu Leu Gln Ser Leu Val Gln Pro 
            260                 265                 270         


Pro Pro Val Ser Pro Val Val Leu Ile Gln Gly Ala Ile Arg Val Gln 
        275                 280                 285             


Pro Glu Gly Pro Ala Pro Ser Leu Pro Arg Pro Glu Arg Lys Ser Ile 
    290                 295                 300                 


Val Pro Ala Pro Met Pro Gly Asn Ser Cys Pro Pro Glu Val Asp Ala 
305                 310                 315                 320 


Lys Leu Leu Lys Arg Gln Gln Arg Met Ile Lys Asn Arg Glu Ser Ala 
                325                 330                 335     


Cys Gln Ser Arg Arg Lys Lys Lys Glu Tyr Leu Gln Gly Leu Glu Ala 
            340                 345                 350         


Arg Leu Gln Ala Val Leu Ala Asp Asn Gln Gln Leu Arg Arg Glu Asn 
        355                 360                 365             


Ala Ala Leu Arg Arg Arg Leu Glu Ala Leu Leu Ala Glu Asn Ser Glu 
    370                 375                 380                 


Leu Lys Leu Gly Ser Gly Asn Arg Lys Val Val Cys Ile Met Val Phe 
385                 390                 395                 400 


Leu Leu Phe Ile Ala Phe Asn Phe Gly Pro Val Ser Ile Ser Glu Pro 
                405                 410                 415     


Pro Ser Ala Pro Ile Ser Pro Arg Met Asn Lys Gly Glu Pro Gln Pro 
            420                 425                 430         


Arg Arg His Leu Leu Gly Phe Ser Glu Gln Glu Pro Val Gln Gly Val 
        435                 440                 445             


Glu Pro Leu Gln Gly Ser Ser Gln Gly Pro Lys Glu Pro Gln Pro Ser 
    450                 455                 460                 


Pro Thr Asp Gln Pro Ser Phe Ser Asn Leu Thr Ala Phe Pro Gly Gly 
465                 470                 475                 480 


Ala Lys Glu Leu Leu Leu Arg Asp Leu Asp Gln Leu Phe Leu Ser Ser 
                485                 490                 495     


Asp Cys Arg His Phe Asn Arg Thr Glu Ser Leu Arg Leu Ala Asp Glu 
            500                 505                 510         


Leu Ser Gly Trp Val Gln Arg His Gln Arg Gly Arg Arg Lys Ile Pro 
        515                 520                 525             


Gln Arg Ala Gln Glu Arg Gln Lys Ser Gln Pro Arg Lys Lys Ser Pro 
    530                 535                 540                 


Pro Val Lys Ala Val Pro Ile Gln Pro Pro Gly Pro Pro Glu Arg Asp 
545                 550                 555                 560 


Ser Val Gly Gln Leu Gln Leu Tyr Arg His Pro Asp Arg Ser Gln Pro 
                565                 570                 575     


Ala Phe Leu Asp Ala Ile Asp Arg Arg Glu Asp Thr Phe Tyr Val Val 
            580                 585                 590         


Ser Phe Arg Arg Asp His Leu Leu Leu Pro Ala Ile Ser His Asn Lys 
        595                 600                 605             


Thr Ser Arg Pro Lys Met Ser Leu Val Met Pro Ala Met Ala Pro Asn 
    610                 615                 620                 


Glu Thr Leu Ser Gly Arg Gly Ala Pro Gly Asp Tyr Glu Glu Met Met 
625                 630                 635                 640 


Gln Ile Glu Cys Glu Val Met Asp Thr Arg Val Ile His Ile Lys Thr 
                645                 650                 655     


Ser Thr Val Pro Pro Ser Leu Arg Lys Gln Pro Ser Pro Thr Pro Gly 
            660                 665                 670         


Asn Ala Thr Gly Gly Pro Leu Pro Val Ser Ala Ala Ser Gln Ala His 
        675                 680                 685             


Gln Ala Ser His Gln Pro Leu Tyr Leu Asn His Pro 
    690                 695                 700 


<210>  882
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF6__Homo_sapiens__NP_031374

<400>  882

Met Gly Glu Pro Ala Gly Val Ala Gly Thr Met Glu Ser Pro Phe Ser 
1               5                   10                  15      


Pro Gly Leu Phe His Arg Leu Asp Glu Asp Trp Asp Ser Ala Leu Phe 
            20                  25                  30          


Ala Glu Leu Gly Tyr Phe Thr Asp Thr Asp Glu Leu Gln Leu Glu Ala 
        35                  40                  45              


Ala Asn Glu Thr Tyr Glu Asn Asn Phe Asp Asn Leu Asp Phe Asp Leu 
    50                  55                  60                  


Asp Leu Met Pro Trp Glu Ser Asp Ile Trp Asp Ile Asn Asn Gln Ile 
65                  70                  75                  80  


Cys Thr Val Lys Asp Ile Lys Ala Glu Pro Gln Pro Leu Ser Pro Ala 
                85                  90                  95      


Ser Ser Ser Tyr Ser Val Ser Ser Pro Arg Ser Val Asp Ser Tyr Ser 
            100                 105                 110         


Ser Thr Gln His Val Pro Glu Glu Leu Asp Leu Ser Ser Ser Ser Gln 
        115                 120                 125             


Met Ser Pro Leu Ser Leu Tyr Gly Glu Asn Ser Asn Ser Leu Ser Ser 
    130                 135                 140                 


Ala Glu Pro Leu Lys Glu Asp Lys Pro Val Thr Gly Pro Arg Asn Lys 
145                 150                 155                 160 


Thr Glu Asn Gly Leu Thr Pro Lys Lys Lys Ile Gln Val Asn Ser Lys 
                165                 170                 175     


Pro Ser Ile Gln Pro Lys Pro Leu Leu Leu Pro Ala Ala Pro Lys Thr 
            180                 185                 190         


Gln Thr Asn Ser Ser Val Pro Ala Lys Thr Ile Ile Ile Gln Thr Val 
        195                 200                 205             


Pro Thr Leu Met Pro Leu Ala Lys Gln Gln Pro Ile Ile Ser Leu Gln 
    210                 215                 220                 


Pro Ala Pro Thr Lys Gly Gln Thr Val Leu Leu Ser Gln Pro Thr Val 
225                 230                 235                 240 


Val Gln Leu Gln Ala Pro Gly Val Leu Pro Ser Ala Gln Pro Val Leu 
                245                 250                 255     


Ala Val Ala Gly Gly Val Thr Gln Leu Pro Asn His Val Val Asn Val 
            260                 265                 270         


Val Pro Ala Pro Ser Ala Asn Ser Pro Val Asn Gly Lys Leu Ser Val 
        275                 280                 285             


Thr Lys Pro Val Leu Gln Ser Thr Met Arg Asn Val Gly Ser Asp Ile 
    290                 295                 300                 


Ala Val Leu Arg Arg Gln Gln Arg Met Ile Lys Asn Arg Glu Ser Ala 
305                 310                 315                 320 


Cys Gln Ser Arg Lys Lys Lys Lys Glu Tyr Met Leu Gly Leu Glu Ala 
                325                 330                 335     


Arg Leu Lys Ala Ala Leu Ser Glu Asn Glu Gln Leu Lys Lys Glu Asn 
            340                 345                 350         


Gly Thr Leu Lys Arg Gln Leu Asp Glu Val Val Ser Glu Asn Gln Arg 
        355                 360                 365             


Leu Lys Val Pro Ser Pro Lys Arg Arg Val Val Cys Val Met Ile Val 
    370                 375                 380                 


Leu Ala Phe Ile Ile Leu Asn Tyr Gly Pro Met Ser Met Leu Glu Gln 
385                 390                 395                 400 


Asp Ser Arg Arg Met Asn Pro Ser Val Ser Pro Ala Asn Gln Arg Arg 
                405                 410                 415     


His Leu Leu Gly Phe Ser Ala Lys Glu Ala Gln Asp Thr Ser Asp Gly 
            420                 425                 430         


Ile Ile Gln Lys Asn Ser Tyr Arg Tyr Asp His Ser Val Ser Asn Asp 
        435                 440                 445             


Lys Ala Leu Met Val Leu Thr Glu Glu Pro Leu Leu Tyr Ile Pro Pro 
    450                 455                 460                 


Pro Pro Cys Gln Pro Leu Ile Asn Thr Thr Glu Ser Leu Arg Leu Asn 
465                 470                 475                 480 


His Glu Leu Arg Gly Trp Val His Arg His Glu Val Glu Arg Thr Lys 
                485                 490                 495     


Ser Arg Arg Met Thr Asn Asn Gln Gln Lys Thr Arg Ile Leu Gln Gly 
            500                 505                 510         


Ala Leu Glu Gln Gly Ser Asn Ser Gln Leu Met Ala Val Gln Tyr Thr 
        515                 520                 525             


Glu Thr Thr Ser Ser Ile Ser Arg Asn Ser Gly Ser Glu Leu Gln Val 
    530                 535                 540                 


Tyr Tyr Ala Ser Pro Arg Ser Tyr Gln Asp Phe Phe Glu Ala Ile Arg 
545                 550                 555                 560 


Arg Arg Gly Asp Thr Phe Tyr Val Val Ser Phe Arg Arg Asp His Leu 
                565                 570                 575     


Leu Leu Pro Ala Thr Thr His Asn Lys Thr Thr Arg Pro Lys Met Ser 
            580                 585                 590         


Ile Val Leu Pro Ala Ile Asn Ile Asn Glu Asn Val Ile Asn Gly Gln 
        595                 600                 605             


Asp Tyr Glu Val Met Met Gln Ile Asp Cys Gln Val Met Asp Thr Arg 
    610                 615                 620                 


Ile Leu His Ile Lys Ser Ser Ser Val Pro Pro Tyr Leu Arg Asp Gln 
625                 630                 635                 640 


Gln Arg Asn Gln Thr Asn Thr Phe Phe Gly Ser Pro Pro Ala Ala Thr 
                645                 650                 655     


Glu Ala Thr His Val Val Ser Thr Ile Pro Glu Ser Leu Gln 
            660                 665                 670 


<210>  883
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF7__Homo_sapiens__NP_001123532

<400>  883

Met Gly Asp Asp Arg Pro Phe Val Cys Asn Ala Pro Gly Cys Gly Gln 
1               5                   10                  15      


Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys His Glu 
            20                  25                  30          


Met Thr Leu Lys Phe Gly Pro Ala Arg Thr Asp Ser Val Ile Ile Ala 
        35                  40                  45              


Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu Glu Val 
    50                  55                  60                  


Gly Leu Phe Asn Glu Leu Ala Ser Ser Phe Glu His Glu Phe Lys Lys 
65                  70                  75                  80  


Ala Ala Asp Glu Asp Glu Lys Lys Ala Ala Ala Gly Pro Leu Asp Met 
                85                  90                  95      


Ser Leu Pro Ser Thr Pro Asp Ile Lys Ile Lys Glu Glu Glu Pro Val 
            100                 105                 110         


Glu Glu Val Thr Pro Lys Pro Val Leu Ile Ser Thr Pro Thr Pro Thr 
        115                 120                 125             


Ile Val Arg Pro Gly Ser Leu Pro Leu His Leu Gly Tyr Asp Pro Leu 
    130                 135                 140                 


His Pro Thr Leu Pro Ser Pro Thr Ser Val Ile Thr Gln Ala Pro Pro 
145                 150                 155                 160 


Ser Asn Arg Gln Met Gly Ser Pro Thr Gly Ser Leu Pro Leu Val Met 
                165                 170                 175     


His Leu Ala Asn Gly Gln Thr Met Pro Val Leu Pro Gly Pro Pro Val 
            180                 185                 190         


Gln Met Pro Ser Val Ile Ser Leu Ala Arg Pro Val Ser Met Val Pro 
        195                 200                 205             


Asn Ile Pro Gly Ile Pro Gly Pro Pro Val Asn Ser Ser Gly Ser Ile 
    210                 215                 220                 


Ser Pro Ser Gly His Pro Ile Pro Ser Glu Ala Lys Met Arg Leu Lys 
225                 230                 235                 240 


Ala Thr Leu Thr His Gln Val Ser Ser Ile Asn Gly Gly Cys Gly Met 
                245                 250                 255     


Val Val Gly Thr Ala Ser Thr Met Val Thr Ala Arg Pro Glu Gln Ser 
            260                 265                 270         


Gln Ile Leu Ile Gln His Pro Asp Ala Pro Ser Pro Ala Gln Pro Gln 
        275                 280                 285             


Val Ser Pro Ala Gln Pro Thr Pro Ser Thr Gly Gly Arg Arg Arg Arg 
    290                 295                 300                 


Thr Val Asp Glu Asp Pro Asp Glu Arg Arg Gln Arg Phe Leu Glu Arg 
305                 310                 315                 320 


Asn Arg Ala Ala Ala Ser Arg Cys Arg Gln Lys Arg Lys Leu Trp Val 
                325                 330                 335     


Ser Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr Ser Gln Asn Ile Gln 
            340                 345                 350         


Leu Ser Asn Glu Val Thr Leu Leu Arg Asn Glu Val Ala Gln Leu Lys 
        355                 360                 365             


Gln Leu Leu Leu Ala His Lys Asp Cys Pro Val Thr Ala Leu Gln Lys 
    370                 375                 380                 


Lys Thr Gln Gly Tyr Leu Glu Ser Pro Lys Glu Ser Ser Glu Pro Thr 
385                 390                 395                 400 


Gly Ser Pro Ala Pro Val Ile Gln His Ser Ser Ala Thr Ala Pro Ser 
                405                 410                 415     


Asn Gly Leu Ser Val Arg Ser Ala Ala Glu Ala Val Ala Thr Ser Val 
            420                 425                 430         


Leu Thr Gln Met Ala Ser Gln Arg Thr Glu Leu Ser Met Pro Ile Gln 
        435                 440                 445             


Ser His Val Ile Met Thr Pro Gln Ser Gln Ser Ala Gly Arg 
    450                 455                 460         


<210>  884
<211>  1105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATF7IP__Homo_sapiens__NP_001273444

<400>  884

Met Asp Ser Leu Glu Glu Pro Gln Lys Lys Val Phe Lys Ala Arg Lys 
1               5                   10                  15      


Thr Met Arg Val Ser Asp Arg Gln Gln Leu Glu Ala Val Tyr Lys Val 
            20                  25                  30          


Lys Glu Glu Leu Leu Lys Thr Asp Val Lys Leu Leu Asn Gly Asn His 
        35                  40                  45              


Glu Asn Gly Asp Leu Asp Pro Thr Ser Pro Leu Glu Asn Met Asp Tyr 
    50                  55                  60                  


Ile Lys Asp Lys Glu Glu Val Asn Gly Ile Glu Glu Ile Cys Phe Asp 
65                  70                  75                  80  


Pro Glu Gly Ser Lys Ala Glu Trp Lys Glu Thr Pro Cys Ile Leu Ser 
                85                  90                  95      


Val Asn Val Lys Asn Lys Gln Asp Asp Asp Leu Asn Cys Glu Pro Leu 
            100                 105                 110         


Ser Pro His Asn Ile Thr Pro Glu Pro Val Ser Lys Leu Pro Ala Glu 
        115                 120                 125             


Pro Val Ser Gly Asp Pro Ala Pro Gly Asp Leu Asp Ala Gly Asp Pro 
    130                 135                 140                 


Ala Ser Gly Val Leu Ala Ser Gly Asp Ser Thr Ser Gly Asp Pro Thr 
145                 150                 155                 160 


Ser Ser Glu Pro Ser Ser Ser Asp Ala Ala Ser Gly Asp Ala Thr Ser 
                165                 170                 175     


Gly Asp Ala Pro Ser Gly Asp Val Ser Pro Gly Asp Ala Thr Ser Gly 
            180                 185                 190         


Asp Ala Thr Ala Asp Asp Leu Ser Ser Gly Asp Pro Thr Ser Ser Asp 
        195                 200                 205             


Pro Ile Pro Gly Glu Pro Val Pro Val Glu Pro Ile Ser Gly Asp Cys 
    210                 215                 220                 


Ala Ala Asp Asp Ile Ala Ser Ser Glu Ile Thr Ser Val Asp Leu Ala 
225                 230                 235                 240 


Ser Gly Ala Pro Ala Ser Thr Asp Pro Ala Ser Asp Asp Leu Ala Ser 
                245                 250                 255     


Gly Asp Leu Ser Ser Ser Glu Leu Ala Ser Asp Asp Leu Ala Thr Gly 
            260                 265                 270         


Glu Leu Ala Ser Asp Glu Leu Thr Ser Glu Ser Thr Phe Asp Arg Thr 
        275                 280                 285             


Phe Glu Pro Lys Ser Val Pro Val Cys Glu Pro Val Pro Glu Ile Asp 
    290                 295                 300                 


Asn Ile Glu Pro Ser Ser Asn Lys Asp Asp Asp Phe Leu Glu Lys Asn 
305                 310                 315                 320 


Gly Ala Asp Glu Lys Leu Glu Gln Ile Gln Ser Lys Asp Ser Leu Asp 
                325                 330                 335     


Glu Lys Asn Lys Ala Asp Asn Asn Ile Asp Ala Asn Glu Glu Thr Leu 
            340                 345                 350         


Glu Thr Asp Asp Thr Thr Ile Cys Ser Asp Arg Pro Pro Glu Asn Glu 
        355                 360                 365             


Lys Lys Val Glu Glu Asp Ile Ile Thr Glu Leu Ala Leu Gly Glu Asp 
    370                 375                 380                 


Ala Ile Ser Ser Ser Met Glu Ile Asp Gln Gly Glu Lys Asn Glu Asp 
385                 390                 395                 400 


Glu Thr Ser Ala Asp Leu Val Glu Thr Ile Asn Glu Asn Val Ile Glu 
                405                 410                 415     


Asp Asn Lys Ser Glu Asn Ile Leu Glu Asn Thr Asp Ser Met Glu Thr 
            420                 425                 430         


Asp Glu Ile Ile Pro Ile Leu Glu Lys Leu Ala Pro Ser Glu Asp Glu 
        435                 440                 445             


Leu Thr Cys Phe Ser Lys Thr Ser Leu Leu Pro Ile Asp Glu Thr Asn 
    450                 455                 460                 


Pro Asp Leu Glu Glu Lys Met Glu Ser Ser Phe Gly Ser Pro Ser Lys 
465                 470                 475                 480 


Gln Glu Ser Ser Glu Ser Leu Pro Lys Glu Ala Phe Leu Val Leu Ser 
                485                 490                 495     


Asp Glu Glu Asp Ile Ser Gly Glu Lys Asp Glu Ser Glu Val Ile Ser 
            500                 505                 510         


Gln Asn Glu Thr Cys Ser Pro Glu Val Glu Ser Asn Glu Lys Asp Asn 
        515                 520                 525             


Lys Pro Glu Glu Glu Glu Gln Val Ile His Glu Asp Asp Glu Arg Pro 
    530                 535                 540                 


Ser Glu Lys Asn Glu Phe Ser Arg Arg Lys Arg Ser Lys Ser Glu Asp 
545                 550                 555                 560 


Met Asp Asn Val Gln Ser Lys Arg Arg Arg Tyr Met Glu Glu Glu Tyr 
                565                 570                 575     


Glu Ala Glu Phe Gln Val Lys Ile Thr Ala Lys Gly Asp Ile Asn Gln 
            580                 585                 590         


Lys Leu Gln Lys Val Ile Gln Trp Leu Leu Glu Glu Lys Leu Cys Ala 
        595                 600                 605             


Leu Gln Cys Ala Val Phe Asp Lys Thr Leu Ala Glu Leu Lys Thr Arg 
    610                 615                 620                 


Val Glu Lys Ile Glu Cys Asn Lys Arg His Lys Thr Val Leu Thr Glu 
625                 630                 635                 640 


Leu Gln Ala Lys Ile Ala Arg Leu Thr Lys Arg Phe Glu Ala Ala Lys 
                645                 650                 655     


Glu Asp Leu Lys Lys Arg His Glu His Pro Pro Asn Pro Pro Val Ser 
            660                 665                 670         


Pro Gly Lys Thr Val Asn Asp Val Asn Ser Asn Asn Asn Met Ser Tyr 
        675                 680                 685             


Arg Asn Ala Gly Thr Val Arg Gln Met Leu Glu Ser Lys Arg Asn Val 
    690                 695                 700                 


Ser Glu Ser Ala Pro Pro Ser Phe Gln Thr Pro Val Asn Thr Val Ser 
705                 710                 715                 720 


Ser Thr Asn Leu Val Thr Pro Pro Ala Val Val Ser Ser Gln Pro Lys 
                725                 730                 735     


Leu Gln Thr Pro Val Thr Ser Gly Ser Leu Thr Ala Thr Ser Val Leu 
            740                 745                 750         


Pro Ala Pro Asn Thr Ala Thr Val Val Ala Thr Thr Gln Val Pro Ser 
        755                 760                 765             


Gly Asn Pro Gln Pro Thr Ile Ser Leu Gln Pro Leu Pro Val Ile Leu 
    770                 775                 780                 


His Val Pro Val Ala Val Ser Ser Gln Pro Gln Leu Leu Gln Ser His 
785                 790                 795                 800 


Pro Gly Thr Leu Val Thr Asn Gln Pro Ser Gly Asn Val Glu Phe Ile 
                805                 810                 815     


Ser Val Gln Ser Pro Pro Thr Val Ser Gly Leu Thr Lys Asn Pro Val 
            820                 825                 830         


Ser Leu Pro Ser Leu Pro Asn Pro Thr Lys Pro Asn Asn Val Pro Ser 
        835                 840                 845             


Val Pro Ser Pro Ser Ile Gln Arg Asn Pro Thr Ala Ser Ala Ala Pro 
    850                 855                 860                 


Leu Gly Thr Thr Leu Ala Val Gln Ala Val Pro Thr Ala His Ser Ile 
865                 870                 875                 880 


Val Gln Ala Thr Arg Thr Ser Leu Pro Thr Val Gly Pro Ser Gly Leu 
                885                 890                 895     


Tyr Ser Pro Ser Thr Asn Arg Gly Pro Ile Gln Met Lys Ile Pro Ile 
            900                 905                 910         


Ser Ala Phe Ser Thr Ser Ser Ala Ala Glu Gln Asn Ser Asn Thr Thr 
        915                 920                 925             


Pro Arg Ile Glu Asn Gln Thr Asn Lys Thr Ile Asp Ala Ser Val Ser 
    930                 935                 940                 


Lys Lys Ala Ala Asp Ser Thr Ser Gln Cys Gly Lys Ala Thr Gly Ser 
945                 950                 955                 960 


Asp Ser Ser Gly Val Ile Asp Leu Thr Met Asp Asp Glu Glu Ser Gly 
                965                 970                 975     


Ala Ser Gln Asp Pro Lys Lys Leu Asn His Thr Pro Val Ser Thr Met 
            980                 985                 990         


Ser Ser Ser Gln Pro Val Ser Arg  Pro Leu Gln Pro Ile  Gln Pro Ala 
        995                 1000                 1005             


Pro Pro  Leu Gln Pro Ser Gly  Val Pro Thr Ser Gly  Pro Ser Gln 
    1010                 1015                 1020             


Thr Thr  Ile His Leu Leu Pro  Thr Ala Pro Thr Thr  Val Asn Val 
    1025                 1030                 1035             


Thr His  Arg Pro Val Thr Gln  Val Thr Thr Arg Leu  Pro Val Pro 
    1040                 1045                 1050             


Arg Ala  Pro Ala Asn His Gln  Val Val Tyr Thr Thr  Leu Pro Ala 
    1055                 1060                 1065             


Pro Pro  Ala Gln Ala Pro Leu  Arg Gly Thr Val Met  Gln Ala Pro 
    1070                 1075                 1080             


Ala Val  Arg Gln Val Asn Pro  Gln Asn Ser Lys Arg  Phe Phe Leu 
    1085                 1090                 1095             


Tyr Met  Ala Pro Arg Tyr Met  
    1100                 1105 


<210>  885
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG10__Homo_sapiens__XP_005248667

<400>  885

Met Glu Glu Asp Glu Phe Ile Gly Glu Lys Thr Phe Gln Arg Tyr Cys 
1               5                   10                  15      


Ala Glu Phe Ile Lys His Ser Gln Gln Ile Gly Asp Ser Trp Glu Trp 
            20                  25                  30          


Arg Pro Ser Lys Asp Cys Ser Asp Gly Tyr Met Cys Lys Ile His Phe 
        35                  40                  45              


Gln Ile Lys Asn Gly Ser Val Met Ser His Leu Gly Ala Ser Thr His 
    50                  55                  60                  


Gly Gln Thr Cys Leu Pro Met Glu Glu Ala Phe Glu Leu Pro Leu Asp 
65                  70                  75                  80  


Asp Cys Glu Val Ile Glu Thr Ala Ala Ala Ser Glu Val Ile Lys Tyr 
                85                  90                  95      


Glu Tyr His Val Leu Tyr Ser Cys Ser Tyr Gln Val Pro Val Leu Tyr 
            100                 105                 110         


Phe Arg Ala Ser Phe Leu Asp Gly Arg Pro Leu Thr Leu Lys Asp Ile 
        115                 120                 125             


Trp Glu Gly Val His Glu Cys Tyr Lys Met Arg Leu Leu Gln Gly Pro 
    130                 135                 140                 


Trp Asp Thr Ile Thr Gln Gln Glu His Pro Ile Leu Gly Gln Pro Phe 
145                 150                 155                 160 


Phe Val Leu His Pro Cys Lys Thr Asn Glu Phe Met Thr Pro Val Leu 
                165                 170                 175     


Lys Asn Ser Gln Lys Ile Asn Lys Asn Val Asn Tyr Ile Thr Ser Trp 
            180                 185                 190         


Leu Ser Ile Val Gly Pro Val Val Gly Leu Asn Leu Pro Leu Ser Tyr 
        195                 200                 205             


Ala Lys Ala Thr Ser Gln Asp Glu Arg Asn Val Pro 
    210                 215                 220 


<210>  886
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG12__Homo_sapiens__NP_001264712

<400>  886

Met Ala Glu Glu Pro Gln Ser Val Leu Gln Leu Pro Thr Ser Ile Ala 
1               5                   10                  15      


Ala Gly Gly Glu Gly Leu Thr Asp Val Ser Pro Glu Thr Thr Thr Pro 
            20                  25                  30          


Glu Pro Pro Ser Ser Ala Ala Val Ser Pro Gly Thr Glu Glu Pro Ala 
        35                  40                  45              


Gly Asp Thr Lys Lys Lys Ile Tyr Leu Cys Glu Ser Val Leu Cys Ser 
    50                  55                  60                  


Phe Pro Arg Pro Arg Ser Trp Asn Ser Leu 
65                  70                  


<210>  887
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG16L1__Homo_sapiens__NP_060444

<400>  887

Met Ser Ser Gly Leu Arg Ala Ala Asp Phe Pro Arg Trp Lys Arg His 
1               5                   10                  15      


Ile Ser Glu Gln Leu Arg Arg Arg Asp Arg Leu Gln Arg Gln Ala Phe 
            20                  25                  30          


Glu Glu Ile Ile Leu Gln Tyr Asn Lys Leu Leu Glu Lys Ser Asp Leu 
        35                  40                  45              


His Ser Val Leu Ala Gln Lys Leu Gln Ala Glu Lys His Asp Val Pro 
    50                  55                  60                  


Asn Arg His Glu Ile Ser Pro Gly His Asp Gly Thr Trp Asn Asp Asn 
65                  70                  75                  80  


Gln Leu Gln Glu Met Ala Gln Leu Arg Ile Lys His Gln Glu Glu Leu 
                85                  90                  95      


Thr Glu Leu His Lys Lys Arg Gly Glu Leu Ala Gln Leu Val Ile Asp 
            100                 105                 110         


Leu Asn Asn Gln Met Gln Arg Lys Asp Arg Glu Met Gln Met Asn Glu 
        115                 120                 125             


Ala Lys Ile Ala Glu Cys Leu Gln Thr Ile Ser Asp Leu Glu Thr Glu 
    130                 135                 140                 


Cys Leu Asp Leu Arg Thr Lys Leu Cys Asp Leu Glu Arg Ala Asn Gln 
145                 150                 155                 160 


Thr Leu Lys Asp Glu Tyr Asp Ala Leu Gln Ile Thr Phe Thr Ala Leu 
                165                 170                 175     


Glu Gly Lys Leu Arg Lys Thr Thr Glu Glu Asn Gln Glu Leu Val Thr 
            180                 185                 190         


Arg Trp Met Ala Glu Lys Ala Gln Glu Ala Asn Arg Leu Asn Ala Glu 
        195                 200                 205             


Asn Glu Lys Asp Ser Arg Arg Arg Gln Ala Arg Leu Gln Lys Glu Leu 
    210                 215                 220                 


Ala Glu Ala Ala Lys Glu Pro Leu Pro Val Glu Gln Asp Asp Asp Ile 
225                 230                 235                 240 


Glu Val Ile Val Asp Glu Thr Ser Asp His Thr Glu Glu Thr Ser Pro 
                245                 250                 255     


Val Arg Ala Ile Ser Arg Ala Ala Thr Arg Arg Ser Val Ser Ser Phe 
            260                 265                 270         


Pro Val Pro Gln Asp Asn Val Asp Thr His Pro Gly Ser Gly Lys Glu 
        275                 280                 285             


Val Arg Val Pro Ala Thr Ala Leu Cys Val Phe Asp Ala His Asp Gly 
    290                 295                 300                 


Glu Val Asn Ala Val Gln Phe Ser Pro Gly Ser Arg Leu Leu Ala Thr 
305                 310                 315                 320 


Gly Gly Met Asp Arg Arg Val Lys Leu Trp Glu Val Phe Gly Glu Lys 
                325                 330                 335     


Cys Glu Phe Lys Gly Ser Leu Ser Gly Ser Asn Ala Gly Ile Thr Ser 
            340                 345                 350         


Ile Glu Phe Asp Ser Ala Gly Ser Tyr Leu Leu Ala Ala Ser Asn Asp 
        355                 360                 365             


Phe Ala Ser Arg Ile Trp Thr Val Asp Asp Tyr Arg Leu Arg His Thr 
    370                 375                 380                 


Leu Thr Gly His Ser Gly Lys Val Leu Ser Ala Lys Phe Leu Leu Asp 
385                 390                 395                 400 


Asn Ala Arg Ile Val Ser Gly Ser His Asp Arg Thr Leu Lys Leu Trp 
                405                 410                 415     


Asp Leu Arg Ser Lys Val Cys Ile Lys Thr Val Phe Ala Gly Ser Ser 
            420                 425                 430         


Cys Asn Asp Ile Val Cys Thr Glu Gln Cys Val Met Ser Gly His Phe 
        435                 440                 445             


Asp Lys Lys Ile Arg Phe Trp Asp Ile Arg Ser Glu Ser Ile Val Arg 
    450                 455                 460                 


Glu Met Glu Leu Leu Gly Lys Ile Thr Ala Leu Asp Leu Asn Pro Glu 
465                 470                 475                 480 


Arg Thr Glu Leu Leu Ser Cys Ser Arg Asp Asp Leu Leu Lys Val Ile 
                485                 490                 495     


Asp Leu Arg Thr Asn Ala Ile Lys Gln Thr Phe Ser Ala Pro Gly Phe 
            500                 505                 510         


Lys Cys Gly Ser Asp Trp Thr Arg Val Val Phe Ser Pro Asp Gly Ser 
        515                 520                 525             


Tyr Val Ala Ala Gly Ser Ala Glu Gly Ser Leu Tyr Ile Trp Ser Val 
    530                 535                 540                 


Leu Thr Gly Lys Val Glu Lys Val Leu Ser Lys Gln His Ser Ser Ser 
545                 550                 555                 560 


Ile Asn Ala Val Ala Trp Ser Pro Ser Gly Ser His Val Val Ser Val 
                565                 570                 575     


Asp Lys Gly Cys Lys Ala Val Leu Trp Ala Gln Tyr 
            580                 585             


<210>  888
<211>  2078
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG2B__Homo_sapiens__NP_060506

<400>  888

Met Pro Trp Pro Phe Ser Glu Ser Ile Lys Lys Arg Ala Cys Arg Tyr 
1               5                   10                  15      


Leu Leu Gln Arg Tyr Leu Gly His Phe Leu Gln Glu Lys Leu Ser Leu 
            20                  25                  30          


Glu Gln Leu Ser Leu Asp Leu Tyr Gln Gly Thr Gly Ser Leu Ala Gln 
        35                  40                  45              


Val Pro Leu Asp Lys Trp Cys Leu Asn Glu Ile Leu Glu Ser Ala Asp 
    50                  55                  60                  


Ala Pro Leu Glu Val Thr Glu Gly Phe Ile Gln Ser Ile Ser Leu Ser 
65                  70                  75                  80  


Val Pro Trp Gly Ser Leu Leu Gln Asp Asn Cys Ala Leu Glu Val Arg 
                85                  90                  95      


Gly Leu Glu Met Val Phe Arg Pro Arg Pro Arg Pro Ala Thr Gly Ser 
            100                 105                 110         


Glu Pro Met Tyr Trp Ser Ser Phe Met Thr Ser Ser Met Gln Leu Ala 
        115                 120                 125             


Lys Glu Cys Leu Ser Gln Lys Leu Thr Asp Glu Gln Gly Glu Gly Ser 
    130                 135                 140                 


Gln Pro Phe Glu Gly Leu Glu Lys Phe Ala Glu Thr Ile Glu Thr Val 
145                 150                 155                 160 


Leu Arg Arg Val Lys Val Thr Phe Ile Asp Thr Val Leu Arg Ile Glu 
                165                 170                 175     


His Val Pro Glu Asn Ser Lys Thr Gly Thr Ala Leu Glu Ile Arg Ile 
            180                 185                 190         


Glu Arg Thr Val Tyr Cys Asp Glu Thr Ala Asp Glu Ser Ser Gly Ile 
        195                 200                 205             


Asn Val His Gln Pro Thr Ala Phe Ala His Lys Leu Leu Gln Leu Ser 
    210                 215                 220                 


Gly Val Ser Leu Phe Trp Asp Glu Phe Ser Ala Ser Ala Lys Ser Ser 
225                 230                 235                 240 


Pro Val Cys Ser Thr Ala Pro Val Glu Thr Glu Pro Lys Leu Ser Pro 
                245                 250                 255     


Ser Trp Asn Pro Lys Ile Ile Tyr Glu Pro His Pro Gln Leu Thr Arg 
            260                 265                 270         


Asn Leu Pro Glu Ile Ala Pro Ser Asp Pro Val Gln Ile Gly Arg Leu 
        275                 280                 285             


Ile Gly Arg Leu Glu Leu Ser Leu Thr Leu Lys Gln Asn Glu Val Leu 
    290                 295                 300                 


Pro Gly Ala Lys Leu Asp Val Asp Gly Gln Ile Asp Ser Ile His Leu 
305                 310                 315                 320 


Leu Leu Ser Pro Arg Gln Val His Leu Leu Leu Asp Met Leu Ala Ala 
                325                 330                 335     


Ile Ala Gly Pro Glu Asn Ser Ser Lys Ile Gly Leu Ala Asn Lys Asp 
            340                 345                 350         


Arg Lys Asn Arg Pro Met Gln Gln Glu Asp Glu Tyr Arg Ile Gln Met 
        355                 360                 365             


Glu Leu Asn Arg Tyr Tyr Leu Arg Lys Asp Ser Leu Ser Val Gly Val 
    370                 375                 380                 


Ser Ser Glu Gln Ser Phe Tyr Glu Thr Glu Thr Ala Arg Thr Pro Ser 
385                 390                 395                 400 


Ser Arg Glu Glu Glu Val Phe Phe Ser Met Ala Asp Met Asp Met Ser 
                405                 410                 415     


His Ser Leu Ser Ser Leu Pro Pro Leu Gly Asp Pro Pro Asn Met Asp 
            420                 425                 430         


Leu Glu Leu Ser Leu Thr Ser Thr Tyr Thr Asn Thr Pro Ala Gly Ser 
        435                 440                 445             


Pro Leu Ser Ala Thr Val Leu Gln Pro Thr Trp Gly Glu Phe Leu Asp 
    450                 455                 460                 


His His Lys Glu Gln Pro Val Arg Gly Ser Thr Phe Pro Ser Asn Leu 
465                 470                 475                 480 


Val His Pro Thr Pro Leu Gln Lys Thr Ser Leu Pro Ser Arg Ser Val 
                485                 490                 495     


Ser Val Asp Glu Ser Arg Pro Glu Leu Ile Phe Arg Leu Ala Val Gly 
            500                 505                 510         


Thr Phe Ser Ile Ser Val Leu His Ile Asp Pro Leu Ser Pro Pro Glu 
        515                 520                 525             


Thr Ser Gln Asn Leu Asn Pro Leu Thr Pro Met Ala Val Ala Phe Phe 
    530                 535                 540                 


Thr Cys Ile Glu Lys Ile Asp Pro Ala Arg Phe Ser Thr Glu Asp Phe 
545                 550                 555                 560 


Lys Ser Phe Arg Ala Val Phe Ala Glu Ala Cys Ser His Asp His Leu 
                565                 570                 575     


Arg Phe Ile Gly Thr Gly Ile Lys Val Ser Tyr Glu Gln Arg Gln Arg 
            580                 585                 590         


Ser Ala Ser Arg Tyr Phe Ser Thr Asp Met Ser Ile Gly Gln Met Glu 
        595                 600                 605             


Phe Leu Glu Cys Leu Phe Pro Thr Asp Phe His Ser Val Pro Pro His 
    610                 615                 620                 


Tyr Thr Glu Leu Leu Thr Phe His Ser Lys Glu Glu Thr Gly Ser His 
625                 630                 635                 640 


Ser Pro Val Cys Leu Gln Leu His Tyr Lys His Ser Glu Asn Arg Gly 
                645                 650                 655     


Pro Gln Gly Asn Gln Ala Arg Leu Ser Ser Val Pro His Lys Ala Glu 
            660                 665                 670         


Leu Gln Ile Lys Leu Asn Pro Val Cys Cys Glu Leu Asp Ile Ser Ile 
        675                 680                 685             


Val Asp Arg Leu Asn Ser Leu Leu Gln Pro Gln Lys Leu Ala Thr Val 
    690                 695                 700                 


Glu Met Met Ala Ser His Met Tyr Thr Ser Tyr Asn Lys His Ile Ser 
705                 710                 715                 720 


Leu His Lys Ala Phe Thr Glu Val Phe Leu Asp Asp Ser His Ser Pro 
                725                 730                 735     


Ala Asn Cys Arg Ile Ser Val Gln Val Ala Thr Pro Ala Leu Asn Leu 
            740                 745                 750         


Ser Val Arg Phe Pro Ile Pro Asp Leu Arg Ser Asp Gln Glu Arg Gly 
        755                 760                 765             


Pro Trp Phe Lys Lys Ser Leu Gln Lys Glu Ile Leu Tyr Leu Ala Phe 
    770                 775                 780                 


Thr Asp Leu Glu Phe Lys Thr Glu Phe Ile Gly Gly Ser Thr Pro Glu 
785                 790                 795                 800 


Gln Ile Lys Leu Glu Leu Thr Phe Arg Glu Leu Ile Gly Ser Phe Gln 
                805                 810                 815     


Glu Glu Lys Gly Asp Pro Ser Ile Lys Phe Phe His Val Ser Ser Gly 
            820                 825                 830         


Val Asp Gly Asp Thr Thr Ser Ser Asp Asp Phe Asp Trp Pro Arg Ile 
        835                 840                 845             


Val Leu Lys Ile Asn Pro Pro Ala Met His Ser Ile Leu Glu Arg Ile 
    850                 855                 860                 


Ala Ala Glu Glu Glu Glu Glu Asn Asp Gly His Tyr Gln Glu Glu Glu 
865                 870                 875                 880 


Glu Gly Gly Ala His Ser Leu Lys Asp Val Cys Asp Leu Arg Arg Pro 
                885                 890                 895     


Ala Pro Ser Pro Phe Ser Ser Arg Arg Val Met Phe Glu Asn Glu Gln 
            900                 905                 910         


Met Val Met Pro Gly Asp Pro Val Glu Met Thr Glu Phe Gln Asp Lys 
        915                 920                 925             


Ala Ile Ser Asn Ser His Tyr Val Leu Glu Leu Thr Leu Pro Asn Ile 
    930                 935                 940                 


Tyr Val Thr Leu Pro Asn Lys Ser Phe Tyr Glu Lys Leu Tyr Asn Arg 
945                 950                 955                 960 


Ile Phe Asn Asp Leu Leu Leu Trp Glu Pro Thr Ala Pro Ser Pro Val 
                965                 970                 975     


Glu Thr Phe Glu Asn Ile Ser Tyr Gly Ile Gly Leu Ser Val Ala Ser 
            980                 985                 990         


Gln Leu Ile Asn Thr Phe Asn Lys  Asp Ser Phe Ser Ala  Phe Lys Ser 
        995                 1000                 1005             


Ala Val  His Tyr Asp Glu Glu  Ser Gly Ser Glu Glu  Glu Thr Leu 
    1010                 1015                 1020             


Gln Tyr  Phe Ser Thr Val Asp  Pro Asn Tyr Arg Ser  Arg Arg Lys 
    1025                 1030                 1035             


Lys Lys  Leu Asp Ser Gln Asn  Lys Asn Ser Gln Ser  Phe Leu Ser 
    1040                 1045                 1050             


Val Leu  Leu Asn Ile Asn His  Gly Leu Ile Ala Val  Phe Thr Asp 
    1055                 1060                 1065             


Val Lys  Gln Asp Asn Gly Asp  Leu Leu Glu Asn Lys  His Gly Glu 
    1070                 1075                 1080             


Phe Trp  Leu Glu Phe Asn Ser  Gly Ser Leu Phe Cys  Val Thr Lys 
    1085                 1090                 1095             


Tyr Glu  Gly Phe Asp Asp Lys  His Tyr Ile Cys Leu  His Ser Ser 
    1100                 1105                 1110             


Ser Phe  Ser Leu Tyr His Lys  Gly Ile Val Asn Gly  Val Ile Leu 
    1115                 1120                 1125             


Pro Thr  Glu Thr Arg Leu Pro  Ser Ser Thr Arg Pro  His Trp Leu 
    1130                 1135                 1140             


Glu Pro  Thr Ile Tyr Ser Ser  Glu Glu Asp Gly Leu  Ser Lys Thr 
    1145                 1150                 1155             


Ser Ser  Asp Gly Val Gly Gly  Asp Ser Leu Asn Met  Leu Ser Val 
    1160                 1165                 1170             


Ala Val  Lys Ile Leu Ser Asp  Lys Ser Glu Ser Asn  Thr Lys Glu 
    1175                 1180                 1185             


Phe Leu  Ile Ala Val Gly Leu  Lys Gly Ala Thr Leu  Gln His Arg 
    1190                 1195                 1200             


Met Leu  Pro Ser Gly Leu Ser  Trp His Glu Gln Ile  Leu Tyr Phe 
    1205                 1210                 1215             


Leu Asn  Ile Ala Asp Glu Pro  Val Leu Gly Tyr Asn  Pro Pro Thr 
    1220                 1225                 1230             


Ser Phe  Thr Thr Phe His Val  His Leu Trp Ser Cys  Ala Leu Asp 
    1235                 1240                 1245             


Tyr Arg  Pro Leu Tyr Leu Pro  Ile Arg Ser Leu Leu  Thr Val Glu 
    1250                 1255                 1260             


Thr Phe  Ser Val Ser Ser Ser  Val Ala Leu Asp Lys  Ser Ser Ser 
    1265                 1270                 1275             


Thr Leu  Arg Ile Ile Leu Asp  Glu Ala Ala Leu His  Leu Ser Asp 
    1280                 1285                 1290             


Lys Cys  Asn Thr Val Thr Ile  Asn Leu Ser Arg Asp  Tyr Val Arg 
    1295                 1300                 1305             


Val Met  Asp Met Gly Leu Leu  Glu Leu Thr Ile Thr  Ala Val Lys 
    1310                 1315                 1320             


Ser Asp  Ser Asp Gly Glu Gln  Thr Glu Pro Arg Phe  Glu Leu His 
    1325                 1330                 1335             


Cys Ser  Ser Asp Val Val His  Ile Arg Thr Cys Ser  Asp Ser Cys 
    1340                 1345                 1350             


Ala Ala  Leu Met Asn Leu Ile  Gln Tyr Ile Ala Ser  Tyr Gly Asp 
    1355                 1360                 1365             


Leu Gln  Thr Pro Asn Lys Ala  Asp Met Lys Pro Gly  Ala Phe Gln 
    1370                 1375                 1380             


Arg Arg  Ser Lys Val Asp Ser  Ser Gly Arg Ser Ser  Ser Arg Gly 
    1385                 1390                 1395             


Pro Val  Leu Pro Glu Ala Asp  Gln Gln Met Leu Arg  Asp Leu Met 
    1400                 1405                 1410             


Ser Asp  Ala Met Glu Glu Ile  Asp Met Gln Gln Gly  Thr Ser Ser 
    1415                 1420                 1425             


Val Lys  Pro Gln Ala Asn Gly  Val Leu Asp Glu Lys  Ser Gln Ile 
    1430                 1435                 1440             


Gln Glu  Pro Cys Cys Ser Asp  Leu Phe Leu Phe Pro  Asp Glu Ser 
    1445                 1450                 1455             


Gly Asn  Val Ser Gln Glu Ser  Gly Pro Thr Tyr Ala  Ser Phe Ser 
    1460                 1465                 1470             


His His  Phe Ile Ser Asp Ala  Met Thr Gly Val Pro  Thr Glu Asn 
    1475                 1480                 1485             


Asp Asp  Phe Cys Ile Leu Phe  Ala Pro Lys Ala Ala  Met Gln Glu 
    1490                 1495                 1500             


Lys Glu  Glu Glu Pro Val Ile  Lys Ile Met Val Asp  Asp Ala Ile 
    1505                 1510                 1515             


Val Ile  Arg Asp Asn Tyr Phe  Ser Leu Pro Val Asn  Lys Thr Asp 
    1520                 1525                 1530             


Thr Ser  Lys Ala Pro Leu His  Phe Pro Ile Pro Val  Ile Arg Tyr 
    1535                 1540                 1545             


Val Val  Lys Glu Val Ser Leu  Val Trp His Leu Tyr  Gly Gly Lys 
    1550                 1555                 1560             


Asp Phe  Gly Thr Val Pro Pro  Thr Ser Pro Ala Lys  Ser Tyr Ile 
    1565                 1570                 1575             


Ser Pro  His Ser Ser Pro Ser  His Thr Pro Thr Arg  His Gly Arg 
    1580                 1585                 1590             


Asn Thr  Val Cys Gly Gly Lys  Gly Arg Asn His Asp  Phe Leu Met 
    1595                 1600                 1605             


Glu Ile  Gln Leu Ser Lys Val  Lys Phe Gln His Glu  Val Tyr Pro 
    1610                 1615                 1620             


Pro Cys  Lys Pro Asp Cys Asp  Ser Ser Leu Ser Glu  His Pro Val 
    1625                 1630                 1635             


Ser Arg  Gln Val Phe Ile Val  Gln Asp Leu Glu Ile  Arg Asp Arg 
    1640                 1645                 1650             


Leu Ala  Thr Ser Gln Met Asn  Lys Phe Leu Tyr Leu  Tyr Cys Ser 
    1655                 1660                 1665             


Lys Glu  Met Pro Arg Lys Ala  His Ser Asn Met Leu  Thr Val Lys 
    1670                 1675                 1680             


Ala Leu  His Val Cys Pro Glu  Ser Gly Arg Ser Pro  Gln Glu Cys 
    1685                 1690                 1695             


Cys Leu  Arg Val Ser Leu Met  Pro Leu Arg Leu Asn  Ile Asp Gln 
    1700                 1705                 1710             


Asp Ala  Leu Phe Phe Leu Lys  Asp Phe Phe Thr Ser  Leu Ser Ala 
    1715                 1720                 1725             


Glu Val  Glu Leu Gln Met Thr  Pro Asp Pro Glu Val  Lys Lys Ser 
    1730                 1735                 1740             


Pro Gly  Ala Asp Val Thr Cys  Ser Leu Pro Arg His  Leu Ser Thr 
    1745                 1750                 1755             


Ser Lys  Glu Pro Asn Leu Val  Ile Ser Phe Ser Gly  Pro Lys Gln 
    1760                 1765                 1770             


Pro Ser  Gln Asn Asp Ser Ala  Asn Ser Val Glu Val  Val Asn Gly 
    1775                 1780                 1785             


Met Glu  Glu Lys Asn Phe Ser  Ala Glu Glu Ala Ser  Phe Arg Asp 
    1790                 1795                 1800             


Gln Pro  Val Phe Phe Arg Glu  Phe Arg Phe Thr Ser  Glu Val Pro 
    1805                 1810                 1815             


Ile Arg  Leu Asp Tyr His Gly  Lys His Val Ser Met  Asp Gln Gly 
    1820                 1825                 1830             


Thr Leu  Ala Gly Ile Leu Ile  Gly Leu Ala Gln Leu  Asn Cys Ser 
    1835                 1840                 1845             


Glu Leu  Lys Leu Lys Arg Leu  Ser Tyr Arg His Gly  Leu Leu Gly 
    1850                 1855                 1860             


Val Asp  Lys Leu Phe Ser Tyr  Ala Ile Thr Glu Trp  Leu Asn Asp 
    1865                 1870                 1875             


Ile Lys  Lys Asn Gln Leu Pro  Gly Ile Leu Gly Gly  Val Gly Pro 
    1880                 1885                 1890             


Met His  Ser Leu Val Gln Leu  Val Gln Gly Leu Lys  Asp Leu Val 
    1895                 1900                 1905             


Trp Leu  Pro Ile Glu Gln Tyr  Arg Lys Asp Gly Arg  Ile Val Arg 
    1910                 1915                 1920             


Gly Phe  Gln Arg Gly Ala Ala  Ser Phe Gly Thr Ser  Thr Ala Met 
    1925                 1930                 1935             


Ala Ala  Leu Glu Leu Thr Asn  Arg Met Val Gln Thr  Ile Gln Ala 
    1940                 1945                 1950             


Ala Ala  Glu Thr Ala Tyr Asp  Met Val Ser Pro Gly  Thr Leu Ser 
    1955                 1960                 1965             


Ile Glu  Pro Lys Lys Thr Lys  Arg Phe Pro His His  Arg Leu Ala 
    1970                 1975                 1980             


His Gln  Pro Val Asp Leu Arg  Glu Gly Val Ala Lys  Ala Tyr Ser 
    1985                 1990                 1995             


Val Val  Lys Glu Gly Ile Thr  Asp Thr Ala Gln Thr  Ile Tyr Glu 
    2000                 2005                 2010             


Thr Ala  Ala Arg Glu His Glu  Ser Arg Gly Val Thr  Gly Ala Val 
    2015                 2020                 2025             


Gly Glu  Val Leu Arg Gln Ile  Pro Pro Ala Val Val  Lys Pro Leu 
    2030                 2035                 2040             


Ile Val  Ala Thr Glu Ala Thr  Ser Asn Val Leu Gly  Gly Met Arg 
    2045                 2050                 2055             


Asn Gln  Ile Arg Pro Asp Val  Arg Gln Asp Glu Ser  Gln Lys Trp 
    2060                 2065                 2070             


Arg His  Gly Asp Asp 
    2075             


<210>  889
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG3__Homo_sapiens__NP_071933

<400>  889

Met Gln Asn Val Ile Asn Thr Val Lys Gly Lys Ala Leu Glu Val Ala 
1               5                   10                  15      


Glu Tyr Leu Thr Pro Val Leu Lys Glu Ser Lys Phe Lys Glu Thr Gly 
            20                  25                  30          


Val Ile Thr Pro Glu Glu Phe Val Ala Ala Gly Asp His Leu Val His 
        35                  40                  45              


His Cys Pro Thr Trp Gln Trp Ala Thr Gly Glu Glu Leu Lys Val Lys 
    50                  55                  60                  


Ala Tyr Leu Pro Thr Gly Lys Gln Phe Leu Val Thr Lys Asn Val Pro 
65                  70                  75                  80  


Cys Tyr Lys Arg Cys Lys Gln Met Glu Tyr Ser Asp Glu Leu Glu Ala 
                85                  90                  95      


Ile Ile Glu Glu Asp Asp Gly Asp Gly Gly Trp Val Asp Thr Tyr His 
            100                 105                 110         


Asn Thr Gly Ile Thr Gly Ile Thr Glu Ala Val Lys Glu Ile Thr Leu 
        115                 120                 125             


Glu Asn Lys Asp Asn Ile Arg Leu Gln Asp Cys Ser Ala Leu Cys Glu 
    130                 135                 140                 


Glu Glu Glu Asp Glu Asp Glu Gly Glu Ala Ala Asp Met Glu Glu Tyr 
145                 150                 155                 160 


Glu Glu Ser Gly Leu Leu Glu Thr Asp Glu Ala Thr Leu Asp Thr Arg 
                165                 170                 175     


Lys Ile Val Glu Ala Cys Lys Ala Lys Thr Asp Ala Gly Gly Glu Asp 
            180                 185                 190         


Ala Ile Leu Gln Thr Arg Thr Tyr Asp Leu Tyr Ile Thr Tyr Asp Lys 
        195                 200                 205             


Tyr Tyr Gln Thr Pro Arg Leu Trp Leu Phe Gly Tyr Asp Glu Gln Arg 
    210                 215                 220                 


Gln Pro Leu Thr Val Glu His Met Tyr Glu Asp Ile Ser Gln Asp His 
225                 230                 235                 240 


Val Lys Lys Thr Val Thr Ile Glu Asn His Pro His Leu Pro Pro Pro 
                245                 250                 255     


Pro Met Cys Ser Val His Pro Cys Arg His Ala Glu Val Met Lys Lys 
            260                 265                 270         


Ile Ile Glu Thr Val Ala Glu Gly Gly Gly Glu Leu Gly Val His Met 
        275                 280                 285             


Tyr Leu Leu Ile Phe Leu Lys Phe Val Gln Ala Val Ile Pro Thr Ile 
    290                 295                 300                 


Glu Tyr Asp Tyr Thr Arg His Phe Thr Met 
305                 310                 


<210>  890
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG4A__Homo_sapiens__NP_443168

<400>  890

Met Glu Ser Val Leu Ser Lys Tyr Glu Asp Gln Ile Thr Ile Phe Thr 
1               5                   10                  15      


Asp Tyr Leu Glu Glu Tyr Pro Asp Thr Asp Glu Leu Val Trp Ile Leu 
            20                  25                  30          


Gly Lys Gln His Leu Leu Lys Thr Glu Lys Ser Lys Leu Leu Ser Asp 
        35                  40                  45              


Ile Ser Ala Arg Leu Trp Phe Thr Tyr Arg Arg Lys Phe Ser Pro Ile 
    50                  55                  60                  


Gly Gly Thr Gly Pro Ser Ser Asp Ala Gly Trp Gly Cys Met Leu Arg 
65                  70                  75                  80  


Cys Gly Gln Met Met Leu Ala Gln Ala Leu Ile Cys Arg His Leu Gly 
                85                  90                  95      


Arg Asp Trp Ser Trp Glu Lys Gln Lys Glu Gln Pro Lys Glu Tyr Gln 
            100                 105                 110         


Arg Ile Leu Gln Cys Phe Leu Asp Arg Lys Asp Cys Cys Tyr Ser Ile 
        115                 120                 125             


His Gln Met Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Glu 
    130                 135                 140                 


Trp Phe Gly Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Leu 
145                 150                 155                 160 


Phe Asp Glu Trp Asn Ser Leu Ala Val Tyr Val Ser Met Asp Asn Thr 
                165                 170                 175     


Val Val Ile Glu Asp Ile Lys Lys Met Cys Arg Val Leu Pro Leu Ser 
            180                 185                 190         


Ala Asp Thr Ala Gly Asp Arg Pro Pro Asp Ser Leu Thr Ala Ser Asn 
        195                 200                 205             


Gln Ser Lys Gly Thr Ser Ala Tyr Cys Ser Ala Trp Lys Pro Leu Leu 
    210                 215                 220                 


Leu Ile Val Pro Leu Arg Leu Gly Ile Asn Gln Ile Asn Pro Val Tyr 
225                 230                 235                 240 


Val Asp Ala Phe Lys Glu Cys Phe Lys Met Pro Gln Ser Leu Gly Ala 
                245                 250                 255     


Leu Gly Gly Lys Pro Asn Asn Ala Tyr Tyr Phe Ile Gly Phe Leu Gly 
            260                 265                 270         


Asp Glu Leu Ile Phe Leu Asp Pro His Thr Thr Gln Thr Phe Val Asp 
        275                 280                 285             


Thr Glu Glu Asn Gly Thr Val Asn Asp Gln Thr Phe His Cys Leu Gln 
    290                 295                 300                 


Ser Pro Gln Arg Met Asn Ile Leu Asn Leu Asp Pro Ser Val Ala Leu 
305                 310                 315                 320 


Gly Phe Phe Cys Lys Glu Glu Lys Asp Phe Asp Asn Trp Cys Ser Leu 
                325                 330                 335     


Val Gln Lys Glu Ile Leu Lys Glu Asn Leu Arg Met Phe Glu Leu Val 
            340                 345                 350         


Gln Lys His Pro Ser His Trp Pro Pro Phe Val Pro Pro Ala Lys Pro 
        355                 360                 365             


Glu Val Thr Thr Thr Gly Ala Glu Phe Ile Asp Ser Thr Glu Gln Leu 
    370                 375                 380                 


Glu Glu Phe Asp Leu Glu Glu Asp Phe Glu Ile Leu Ser Val 
385                 390                 395             


<210>  891
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG4B__Homo_sapiens__NP_037457

<400>  891

Met Asp Ala Ala Thr Leu Thr Tyr Asp Thr Leu Arg Phe Ala Glu Phe 
1               5                   10                  15      


Glu Asp Phe Pro Glu Thr Ser Glu Pro Val Trp Ile Leu Gly Arg Lys 
            20                  25                  30          


Tyr Ser Ile Phe Thr Glu Lys Asp Glu Ile Leu Ser Asp Val Ala Ser 
        35                  40                  45              


Arg Leu Trp Phe Thr Tyr Arg Lys Asn Phe Pro Ala Ile Gly Gly Thr 
    50                  55                  60                  


Gly Pro Thr Ser Asp Thr Gly Trp Gly Cys Met Leu Arg Cys Gly Gln 
65                  70                  75                  80  


Met Ile Phe Ala Gln Ala Leu Val Cys Arg His Leu Gly Arg Asp Trp 
                85                  90                  95      


Arg Trp Thr Gln Arg Lys Arg Gln Pro Asp Ser Tyr Phe Ser Val Leu 
            100                 105                 110         


Asn Ala Phe Ile Asp Arg Lys Asp Ser Tyr Tyr Ser Ile His Gln Ile 
        115                 120                 125             


Ala Gln Met Gly Val Gly Glu Gly Lys Ser Ile Gly Gln Trp Tyr Gly 
    130                 135                 140                 


Pro Asn Thr Val Ala Gln Val Leu Lys Lys Leu Ala Val Phe Asp Thr 
145                 150                 155                 160 


Trp Ser Ser Leu Ala Val His Ile Ala Met Asp Asn Thr Val Val Met 
                165                 170                 175     


Glu Glu Ile Arg Arg Leu Cys Arg Thr Ser Val Pro Cys Ala Gly Ala 
            180                 185                 190         


Thr Ala Phe Pro Ala Asp Ser Asp Arg His Cys Asn Gly Phe Pro Ala 
        195                 200                 205             


Gly Ala Glu Val Thr Asn Arg Pro Ser Pro Trp Arg Pro Leu Val Leu 
    210                 215                 220                 


Leu Ile Pro Leu Arg Leu Gly Leu Thr Asp Ile Asn Glu Ala Tyr Val 
225                 230                 235                 240 


Glu Thr Leu Lys His Cys Phe Met Met Pro Gln Ser Leu Gly Val Ile 
                245                 250                 255     


Gly Gly Lys Pro Asn Ser Ala His Tyr Phe Ile Gly Tyr Val Gly Glu 
            260                 265                 270         


Glu Leu Ile Tyr Leu Asp Pro His Thr Thr Gln Pro Ala Val Glu Pro 
        275                 280                 285             


Thr Asp Gly Cys Phe Ile Pro Asp Glu Ser Phe His Cys Gln His Pro 
    290                 295                 300                 


Pro Cys Arg Met Ser Ile Ala Glu Leu Asp Pro Ser Ile Ala Val Gly 
305                 310                 315                 320 


Phe Phe Cys Lys Thr Glu Asp Asp Phe Asn Asp Trp Cys Gln Gln Val 
                325                 330                 335     


Lys Lys Leu Ser Leu Leu Gly Gly Ala Leu Pro Met Phe Glu Leu Val 
            340                 345                 350         


Glu Leu Gln Pro Ser His Leu Ala Cys Pro Asp Val Leu Asn Leu Ser 
        355                 360                 365             


Leu Asp Ser Ser Asp Val Glu Arg Leu Glu Arg Phe Phe Asp Ser Glu 
    370                 375                 380                 


Asp Glu Asp Phe Glu Ile Leu Ser Leu 
385                 390             


<210>  892
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG4C__Homo_sapiens__XP_011540615

<400>  892

Met Glu Ala Thr Gly Thr Asp Glu Val Asp Lys Leu Lys Thr Lys Phe 
1               5                   10                  15      


Ile Ser Ala Trp Asn Asn Met Lys Tyr Ser Trp Val Leu Lys Thr Lys 
            20                  25                  30          


Thr Tyr Phe Ser Arg Asn Ser Pro Val Leu Leu Leu Gly Lys Cys Tyr 
        35                  40                  45              


His Phe Lys Tyr Glu Asp Glu Asp Lys Thr Leu Pro Ala Glu Ser Gly 
    50                  55                  60                  


Cys Thr Ile Glu Asp His Val Ile Ala Gly Asn Val Glu Glu Phe Arg 
65                  70                  75                  80  


Lys Asp Phe Ile Ser Arg Ile Trp Leu Thr Tyr Arg Glu Glu Phe Pro 
                85                  90                  95      


Gln Ile Glu Gly Ser Ala Leu Thr Thr Asp Cys Gly Trp Gly Cys Thr 
            100                 105                 110         


Leu Arg Thr Gly Gln Met Leu Leu Ala Gln Gly Leu Ile Leu His Phe 
        115                 120                 125             


Leu Gly Arg Ala Trp Thr Trp Pro Asp Ala Leu Asn Ile Glu Asn Ser 
    130                 135                 140                 


Asp Ser Glu Ser Trp Thr Ser His Thr Val Lys Lys Phe Thr Ala Ser 
145                 150                 155                 160 


Phe Glu Ala Ser Leu Ser Gly Glu Arg Glu Phe Lys Thr Pro Thr Ile 
                165                 170                 175     


Ser Leu Lys Glu Thr Ile Gly Lys Tyr Ser Asp Asp His Glu Met Arg 
            180                 185                 190         


Asn Glu Val Tyr His Arg Lys Ile Ile Ser Trp Phe Gly Asp Ser Pro 
        195                 200                 205             


Leu Ala Leu Phe Gly Leu His Gln Leu Ile Glu Tyr Gly Lys Lys Ser 
    210                 215                 220                 


Gly Lys Lys Ala Gly Asp Trp Tyr Gly Pro Ala Val Val Ala His Ile 
225                 230                 235                 240 


Leu Arg Lys Ala Val Glu Glu Ala Arg His Pro Asp Leu Gln Gly Ile 
                245                 250                 255     


Thr Ile Tyr Val Ala Gln Asp Cys Thr Val Tyr Asn Ser Asp Val Ile 
            260                 265                 270         


Asp Lys Gln Ser Ala Ser Met Thr Ser Asp Asn Ala Asp Asp Lys Ala 
        275                 280                 285             


Val Ile Ile Leu Val Pro Val Arg Leu Gly Gly Glu Arg Thr Asn Thr 
    290                 295                 300                 


Asp Tyr Leu Glu Phe Val Lys Gly Ile Leu Ser Leu Glu Tyr Cys Val 
305                 310                 315                 320 


Gly Ile Ile Gly Gly Lys Pro Lys Gln Ser Tyr Tyr Phe Ala Gly Phe 
                325                 330                 335     


Gln Asp Asp Ser Leu Ile Tyr Met Asp Pro His Tyr Cys Gln Ser Phe 
            340                 345                 350         


Val Asp Val Ser Ile Lys Asp Phe Pro Leu Glu Thr Phe His Cys Pro 
        355                 360                 365             


Ser Pro Lys Lys Met Ser Phe Arg Lys Met Asp Pro Ser Cys Thr Ile 
    370                 375                 380                 


Gly Phe Tyr Cys Arg Asn Val Gln Asp Phe Lys Arg Ala Ser Glu Glu 
385                 390                 395                 400 


Ile Thr Lys Asn Gln Ile Met Ile Lys Ala Ala Ile Ile Asn Ile His 
                405                 410                 415     


Val Gln Asp Phe Met Trp Thr 
            420             


<210>  893
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG5__Homo_sapiens__NP_001273035

<400>  893

Met Thr Asp Asp Lys Asp Val Leu Arg Asp Val Trp Phe Gly Arg Ile 
1               5                   10                  15      


Pro Thr Cys Phe Thr Leu Tyr Gln Asp Glu Ile Thr Glu Arg Glu Ala 
            20                  25                  30          


Glu Pro Tyr Tyr Leu Leu Leu Pro Arg Val Ser Tyr Leu Thr Leu Val 
        35                  40                  45              


Thr Asp Lys Val Lys Lys His Phe Gln Lys Val Met Arg Gln Glu Asp 
    50                  55                  60                  


Ile Ser Glu Ile Trp Phe Glu Tyr Glu Gly Thr Pro Leu Lys Trp His 
65                  70                  75                  80  


Tyr Pro Ile Gly Leu Leu Phe Asp Leu Leu Ala Ser Ser Ser Ala Leu 
                85                  90                  95      


Pro Trp Asn Ile Thr Val His Phe Lys Ser Phe Pro Glu Lys Asp Leu 
            100                 105                 110         


Leu His Cys Pro Ser Lys Asp Ala Ile Glu Ala His Phe Met Ser Cys 
        115                 120                 125             


Met Lys Glu Ala Asp Ala Leu Lys His Lys Ser Gln Val Ile Asn Glu 
    130                 135                 140                 


Met Gln Lys Lys Asp His Lys Gln Leu Trp Met Gly Leu Gln Asn Asp 
145                 150                 155                 160 


Arg Phe Asp Gln Phe Trp Ala Ile Asn Arg Lys Leu Met Glu Tyr Pro 
                165                 170                 175     


Ala Glu Glu Asn Gly Phe Arg Tyr Ile Pro Phe Arg Ile Tyr Gln Thr 
            180                 185                 190         


Thr Thr Glu Arg Pro Phe Ile Gln Lys Leu Phe Arg Pro Val Ala Ala 
        195                 200                 205             


Asp Gly Gln Leu His Thr Leu Gly Asp Leu Leu Lys Glu Val Cys Pro 
    210                 215                 220                 


Ser Ala Ile Asp Pro Glu Asp Gly Glu Lys Lys Asn Gln Val Met Ile 
225                 230                 235                 240 


His Gly Ile Glu Pro Met Leu Glu Thr Pro Leu Gln Trp Leu Ser Glu 
                245                 250                 255     


His Leu Ser Tyr Pro Asp Asn Phe Leu His Ile Ser Ile Ile Pro Gln 
            260                 265                 270         


Pro Thr Asp 
        275 


<210>  894
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG7__Homo_sapiens__NP_001129503

<400>  894

Met Ala Ala Ala Thr Gly Asp Pro Gly Leu Ser Lys Leu Gln Phe Ala 
1               5                   10                  15      


Pro Phe Ser Ser Ala Leu Asp Val Gly Phe Trp His Glu Leu Thr Gln 
            20                  25                  30          


Lys Lys Leu Asn Glu Tyr Arg Leu Asp Glu Ala Pro Lys Asp Ile Lys 
        35                  40                  45              


Gly Tyr Tyr Tyr Asn Gly Asp Ser Ala Gly Leu Pro Ala Arg Leu Thr 
    50                  55                  60                  


Leu Glu Phe Ser Ala Phe Asp Met Ser Ala Pro Thr Pro Ala Arg Cys 
65                  70                  75                  80  


Cys Pro Ala Ile Gly Thr Leu Tyr Asn Thr Asn Thr Leu Glu Ser Phe 
                85                  90                  95      


Lys Thr Ala Asp Lys Lys Leu Leu Leu Glu Gln Ala Ala Asn Glu Ile 
            100                 105                 110         


Trp Glu Ser Ile Lys Ser Gly Thr Ala Leu Glu Asn Pro Val Leu Leu 
        115                 120                 125             


Asn Lys Phe Leu Leu Leu Thr Phe Ala Asp Leu Lys Lys Tyr His Phe 
    130                 135                 140                 


Tyr Tyr Trp Phe Cys Tyr Pro Ala Leu Cys Leu Pro Glu Ser Leu Pro 
145                 150                 155                 160 


Leu Ile Gln Gly Pro Val Gly Leu Asp Gln Arg Phe Ser Leu Lys Gln 
                165                 170                 175     


Ile Glu Ala Leu Glu Cys Ala Tyr Asp Asn Leu Cys Gln Thr Glu Gly 
            180                 185                 190         


Val Thr Ala Leu Pro Tyr Phe Leu Ile Lys Tyr Asp Glu Asn Met Val 
        195                 200                 205             


Leu Val Ser Leu Leu Lys His Tyr Ser Asp Phe Phe Gln Gly Gln Arg 
    210                 215                 220                 


Thr Lys Ile Thr Ile Gly Val Tyr Asp Pro Cys Asn Leu Ala Gln Tyr 
225                 230                 235                 240 


Pro Gly Trp Pro Leu Arg Asn Phe Leu Val Leu Ala Ala His Arg Trp 
                245                 250                 255     


Ser Ser Ser Phe Gln Ser Val Glu Val Val Cys Phe Arg Asp Arg Thr 
            260                 265                 270         


Met Gln Gly Ala Arg Asp Val Ala His Ser Ile Ile Phe Glu Val Lys 
        275                 280                 285             


Leu Pro Glu Met Ala Phe Ser Pro Asp Cys Pro Lys Ala Val Gly Trp 
    290                 295                 300                 


Glu Lys Asn Gln Lys Gly Gly Met Gly Pro Arg Met Val Asn Leu Ser 
305                 310                 315                 320 


Glu Cys Met Asp Pro Lys Arg Leu Ala Glu Ser Ser Val Asp Leu Asn 
                325                 330                 335     


Leu Lys Leu Met Cys Trp Arg Leu Val Pro Thr Leu Asp Leu Asp Lys 
            340                 345                 350         


Val Val Ser Val Lys Cys Leu Leu Leu Gly Ala Gly Thr Leu Gly Cys 
        355                 360                 365             


Asn Val Ala Arg Thr Leu Met Gly Trp Gly Val Arg His Ile Thr Phe 
    370                 375                 380                 


Val Asp Asn Ala Lys Ile Ser Tyr Ser Asn Pro Val Arg Gln Pro Leu 
385                 390                 395                 400 


Tyr Glu Phe Glu Asp Cys Leu Gly Gly Gly Lys Pro Lys Ala Leu Ala 
                405                 410                 415     


Ala Ala Asp Arg Leu Gln Lys Ile Phe Pro Gly Val Asn Ala Arg Gly 
            420                 425                 430         


Phe Asn Met Ser Ile Pro Met Pro Gly His Pro Val Asn Phe Ser Ser 
        435                 440                 445             


Val Thr Leu Glu Gln Ala Arg Arg Asp Val Glu Gln Leu Glu Gln Leu 
    450                 455                 460                 


Ile Glu Ser His Asp Val Val Phe Leu Leu Met Asp Thr Arg Glu Ser 
465                 470                 475                 480 


Arg Trp Leu Pro Ala Val Ile Ala Ala Ser Lys Arg Lys Leu Val Ile 
                485                 490                 495     


Asn Ala Ala Leu Gly Phe Asp Thr Phe Val Val Met Arg His Gly Leu 
            500                 505                 510         


Lys Lys Pro Lys Gln Gln Gly Ala Gly Asp Leu Cys Pro Asn His Pro 
        515                 520                 525             


Val Ala Ser Ala Asp Leu Leu Gly Ser Ser Leu Phe Ala Asn Ile Pro 
    530                 535                 540                 


Gly Tyr Lys Leu Gly Cys Tyr Phe Cys Asn Asp Val Val Ala Pro Gly 
545                 550                 555                 560 


Asp Ser Thr Arg Asp Arg Thr Leu Asp Gln Gln Cys Thr Val Ser Arg 
                565                 570                 575     


Pro Gly Leu Ala Val Ile Ala Gly Ala Leu Ala Val Glu Leu Met Val 
            580                 585                 590         


Ser Val Leu Gln His Pro Glu Gly Gly Tyr Ala Ile Ala Ser Ser Ser 
        595                 600                 605             


Asp Asp Arg Met Asn Glu Pro Pro Thr Ser Leu Gly Leu Val Pro His 
    610                 615                 620                 


Gln Val Leu Asp Gln Tyr Glu Arg Glu Gly Phe Asn Phe Leu Ala Lys 
625                 630                 635                 640 


Val Phe Asn Ser Ser His Ser Phe Leu Glu Asp Leu Thr Gly Leu Thr 
                645                 650                 655     


Leu Leu His Gln Glu Thr Gln Ala Ala Glu Ile Trp Asp Met Ser Asp 
            660                 665                 670         


Asp Glu Thr Ile 
        675     


<210>  895
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG9A__Homo_sapiens__NP_001070666

<400>  895

Met Ala Gln Phe Asp Thr Glu Tyr Gln Arg Leu Glu Ala Ser Tyr Ser 
1               5                   10                  15      


Asp Ser Pro Pro Gly Glu Glu Asp Leu Leu Val His Val Ala Glu Gly 
            20                  25                  30          


Ser Lys Ser Pro Trp His His Ile Glu Asn Leu Asp Leu Phe Phe Ser 
        35                  40                  45              


Arg Val Tyr Asn Leu His Gln Lys Asn Gly Phe Thr Cys Met Leu Ile 
    50                  55                  60                  


Gly Glu Ile Phe Glu Leu Met Gln Phe Leu Phe Val Val Ala Phe Thr 
65                  70                  75                  80  


Thr Phe Leu Val Ser Cys Val Asp Tyr Asp Ile Leu Phe Ala Asn Lys 
                85                  90                  95      


Met Val Asn His Ser Leu His Pro Thr Glu Pro Val Lys Val Thr Leu 
            100                 105                 110         


Pro Asp Ala Phe Leu Pro Ala Gln Val Cys Ser Ala Arg Ile Gln Glu 
        115                 120                 125             


Asn Gly Ser Leu Ile Thr Ile Leu Val Ile Ala Gly Val Phe Trp Ile 
    130                 135                 140                 


His Arg Leu Ile Lys Phe Ile Tyr Asn Ile Cys Cys Tyr Trp Glu Ile 
145                 150                 155                 160 


His Ser Phe Tyr Leu His Ala Leu Arg Ile Pro Met Ser Ala Leu Pro 
                165                 170                 175     


Tyr Cys Thr Trp Gln Glu Val Gln Ala Arg Ile Val Gln Thr Gln Lys 
            180                 185                 190         


Glu His Gln Ile Cys Ile His Lys Arg Glu Leu Thr Glu Leu Asp Ile 
        195                 200                 205             


Tyr His Arg Ile Leu Arg Phe Gln Asn Tyr Met Val Ala Leu Val Asn 
    210                 215                 220                 


Lys Ser Leu Leu Pro Leu Arg Phe Arg Leu Pro Gly Leu Gly Glu Ala 
225                 230                 235                 240 


Val Phe Phe Thr Arg Gly Leu Lys Tyr Asn Phe Glu Leu Ile Leu Phe 
                245                 250                 255     


Trp Gly Pro Gly Ser Leu Phe Leu Asn Glu Trp Ser Leu Lys Ala Glu 
            260                 265                 270         


Tyr Lys Arg Gly Gly Gln Arg Leu Glu Leu Ala Gln Arg Leu Ser Asn 
        275                 280                 285             


Arg Ile Leu Trp Ile Gly Ile Ala Asn Phe Leu Leu Cys Pro Leu Ile 
    290                 295                 300                 


Leu Ile Trp Gln Ile Leu Tyr Ala Phe Phe Ser Tyr Ala Glu Val Leu 
305                 310                 315                 320 


Lys Arg Glu Pro Gly Ala Leu Gly Ala Arg Cys Trp Ser Leu Tyr Gly 
                325                 330                 335     


Arg Cys Tyr Leu Arg His Phe Asn Glu Leu Glu His Glu Leu Gln Ser 
            340                 345                 350         


Arg Leu Asn Arg Gly Tyr Lys Pro Ala Ser Lys Tyr Met Asn Cys Phe 
        355                 360                 365             


Leu Ser Pro Leu Leu Thr Leu Leu Ala Lys Asn Gly Ala Phe Phe Ala 
    370                 375                 380                 


Gly Ser Ile Leu Ala Val Leu Ile Ala Leu Thr Ile Tyr Asp Glu Asp 
385                 390                 395                 400 


Val Leu Ala Val Glu His Val Leu Thr Thr Val Thr Leu Leu Gly Val 
                405                 410                 415     


Thr Val Thr Val Cys Arg Ser Phe Ile Pro Asp Gln His Met Val Phe 
            420                 425                 430         


Cys Pro Glu Gln Leu Leu Arg Val Ile Leu Ala His Ile His Tyr Met 
        435                 440                 445             


Pro Asp His Trp Gln Gly Asn Ala His Arg Ser Gln Thr Arg Asp Glu 
    450                 455                 460                 


Phe Ala Gln Leu Phe Gln Tyr Lys Ala Val Phe Ile Leu Glu Glu Leu 
465                 470                 475                 480 


Leu Ser Pro Ile Val Thr Pro Leu Ile Leu Ile Phe Cys Leu Arg Pro 
                485                 490                 495     


Arg Ala Leu Glu Ile Ile Asp Phe Phe Arg Asn Phe Thr Val Glu Val 
            500                 505                 510         


Val Gly Val Gly Asp Thr Cys Ser Phe Ala Gln Met Asp Val Arg Gln 
        515                 520                 525             


His Gly His Pro Gln Trp Leu Ser Ala Gly Gln Thr Glu Ala Ser Val 
    530                 535                 540                 


Tyr Gln Gln Ala Glu Asp Gly Lys Thr Glu Leu Ser Leu Met His Phe 
545                 550                 555                 560 


Ala Ile Thr Asn Pro Gly Trp Gln Pro Pro Arg Glu Ser Thr Ala Phe 
                565                 570                 575     


Leu Gly Phe Leu Lys Glu Gln Val Gln Arg Asp Gly Ala Ala Ala Ser 
            580                 585                 590         


Leu Ala Gln Gly Gly Leu Leu Pro Glu Asn Ala Leu Phe Thr Ser Ile 
        595                 600                 605             


Gln Ser Leu Gln Ser Glu Ser Glu Pro Leu Ser Leu Ile Ala Asn Val 
    610                 615                 620                 


Val Ala Gly Ser Ser Cys Arg Gly Pro Pro Leu Pro Arg Asp Leu Gln 
625                 630                 635                 640 


Gly Ser Arg His Arg Ala Glu Val Ala Ser Ala Leu Arg Ser Phe Ser 
                645                 650                 655     


Pro Leu Gln Pro Gly Gln Ala Pro Thr Gly Arg Ala His Ser Thr Met 
            660                 665                 670         


Thr Gly Ser Gly Val Asp Ala Arg Thr Ala Ser Ser Gly Ser Ser Val 
        675                 680                 685             


Trp Glu Gly Gln Leu Gln Ser Leu Val Leu Ser Glu Tyr Ala Ser Thr 
    690                 695                 700                 


Glu Met Ser Leu His Ala Leu Tyr Met His Gln Leu His Lys Gln Gln 
705                 710                 715                 720 


Ala Gln Ala Glu Pro Glu Arg His Val Trp His Arg Arg Glu Ser Asp 
                725                 730                 735     


Glu Ser Gly Glu Ser Ala Pro Asp Glu Gly Gly Glu Gly Ala Arg Ala 
            740                 745                 750         


Pro Gln Ser Ile Pro Arg Ser Ala Ser Tyr Pro Cys Ala Ala Pro Arg 
        755                 760                 765             


Pro Gly Ala Pro Glu Thr Thr Ala Leu His Gly Gly Phe Gln Arg Arg 
    770                 775                 780                 


Tyr Gly Gly Ile Thr Asp Pro Gly Thr Val Pro Arg Val Pro Ser His 
785                 790                 795                 800 


Phe Ser Arg Leu Pro Leu Gly Gly Trp Ala Glu Asp Gly Gln Ser Ala 
                805                 810                 815     


Ser Arg His Pro Glu Pro Val Pro Glu Glu Gly Ser Glu Asp Glu Leu 
            820                 825                 830         


Pro Pro Gln Val His Lys Val 
        835                 


<210>  896
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATIC__Homo_sapiens__NP_004035

<400>  896

Met Ala Pro Gly Gln Leu Ala Leu Phe Ser Val Ser Asp Lys Thr Gly 
1               5                   10                  15      


Leu Val Glu Phe Ala Arg Asn Leu Thr Ala Leu Gly Leu Asn Leu Val 
            20                  25                  30          


Ala Ser Gly Gly Thr Ala Lys Ala Leu Arg Asp Ala Gly Leu Ala Val 
        35                  40                  45              


Arg Asp Val Ser Glu Leu Thr Gly Phe Pro Glu Met Leu Gly Gly Arg 
    50                  55                  60                  


Val Lys Thr Leu His Pro Ala Val His Ala Gly Ile Leu Ala Arg Asn 
65                  70                  75                  80  


Ile Pro Glu Asp Asn Ala Asp Met Ala Arg Leu Asp Phe Asn Leu Ile 
                85                  90                  95      


Arg Val Val Ala Cys Asn Leu Tyr Pro Phe Val Lys Thr Val Ala Ser 
            100                 105                 110         


Pro Gly Val Thr Val Glu Glu Ala Val Glu Gln Ile Asp Ile Gly Gly 
        115                 120                 125             


Val Thr Leu Leu Arg Ala Ala Ala Lys Asn His Ala Arg Val Thr Val 
    130                 135                 140                 


Val Cys Glu Pro Glu Asp Tyr Val Val Val Ser Thr Glu Met Gln Ser 
145                 150                 155                 160 


Ser Glu Ser Lys Asp Thr Ser Leu Glu Thr Arg Arg Gln Leu Ala Leu 
                165                 170                 175     


Lys Ala Phe Thr His Thr Ala Gln Tyr Asp Glu Ala Ile Ser Asp Tyr 
            180                 185                 190         


Phe Arg Lys Gln Tyr Ser Lys Gly Val Ser Gln Met Pro Leu Arg Tyr 
        195                 200                 205             


Gly Met Asn Pro His Gln Thr Pro Ala Gln Leu Tyr Thr Leu Gln Pro 
    210                 215                 220                 


Lys Leu Pro Ile Thr Val Leu Asn Gly Ala Pro Gly Phe Ile Asn Leu 
225                 230                 235                 240 


Cys Asp Ala Leu Asn Ala Trp Gln Leu Val Lys Glu Leu Lys Glu Ala 
                245                 250                 255     


Leu Gly Ile Pro Ala Ala Ala Ser Phe Lys His Val Ser Pro Ala Gly 
            260                 265                 270         


Ala Ala Val Gly Ile Pro Leu Ser Glu Asp Glu Ala Lys Val Cys Met 
        275                 280                 285             


Val Tyr Asp Leu Tyr Lys Thr Leu Thr Pro Ile Ser Ala Ala Tyr Ala 
    290                 295                 300                 


Arg Ala Arg Gly Ala Asp Arg Met Ser Ser Phe Gly Asp Phe Val Ala 
305                 310                 315                 320 


Leu Ser Asp Val Cys Asp Val Pro Thr Ala Lys Ile Ile Ser Arg Glu 
                325                 330                 335     


Val Ser Asp Gly Ile Ile Ala Pro Gly Tyr Glu Glu Glu Ala Leu Thr 
            340                 345                 350         


Ile Leu Ser Lys Lys Lys Asn Gly Asn Tyr Cys Val Leu Gln Met Asp 
        355                 360                 365             


Gln Ser Tyr Lys Pro Asp Glu Asn Glu Val Arg Thr Leu Phe Gly Leu 
    370                 375                 380                 


His Leu Ser Gln Lys Arg Asn Asn Gly Val Val Asp Lys Ser Leu Phe 
385                 390                 395                 400 


Ser Asn Val Val Thr Lys Asn Lys Asp Leu Pro Glu Ser Ala Leu Arg 
                405                 410                 415     


Asp Leu Ile Val Ala Thr Ile Ala Val Lys Tyr Thr Gln Ser Asn Ser 
            420                 425                 430         


Val Cys Tyr Ala Lys Asn Gly Gln Val Ile Gly Ile Gly Ala Gly Gln 
        435                 440                 445             


Gln Ser Arg Ile His Cys Thr Arg Leu Ala Gly Asp Lys Ala Asn Tyr 
    450                 455                 460                 


Trp Trp Leu Arg His His Pro Gln Val Leu Ser Met Lys Phe Lys Thr 
465                 470                 475                 480 


Gly Val Lys Arg Ala Glu Ile Ser Asn Ala Ile Asp Gln Tyr Val Thr 
                485                 490                 495     


Gly Thr Ile Gly Glu Asp Glu Asp Leu Ile Lys Trp Lys Ala Leu Phe 
            500                 505                 510         


Glu Glu Val Pro Glu Leu Leu Thr Glu Ala Glu Lys Lys Glu Trp Val 
        515                 520                 525             


Glu Lys Leu Thr Glu Val Ser Ile Ser Ser Asp Ala Phe Phe Pro Phe 
    530                 535                 540                 


Arg Asp Asn Val Asp Arg Ala Lys Arg Ser Gly Val Ala Tyr Ile Ala 
545                 550                 555                 560 


Ala Pro Ser Gly Ser Ala Ala Asp Lys Val Val Ile Glu Ala Cys Asp 
                565                 570                 575     


Glu Leu Gly Ile Ile Leu Ala His Thr Asn Leu Arg Leu Phe His His 
            580                 585                 590         


<210>  897
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATL1__Homo_sapiens__NP_001121185

<400>  897

Met Ala Lys Asn Arg Arg Asp Arg Asn Ser Trp Gly Gly Phe Ser Glu 
1               5                   10                  15      


Lys Thr Tyr Glu Trp Ser Ser Glu Glu Glu Glu Pro Val Lys Lys Ala 
            20                  25                  30          


Gly Pro Val Gln Val Leu Ile Val Lys Asp Asp His Ser Phe Glu Leu 
        35                  40                  45              


Asp Glu Thr Ala Leu Asn Arg Ile Leu Leu Ser Glu Ala Val Arg Asp 
    50                  55                  60                  


Lys Glu Val Val Ala Val Ser Val Ala Gly Ala Phe Arg Lys Gly Lys 
65                  70                  75                  80  


Ser Phe Leu Met Asp Phe Met Leu Arg Tyr Met Tyr Asn Gln Glu Ser 
                85                  90                  95      


Val Asp Trp Val Gly Asp Tyr Asn Glu Pro Leu Thr Gly Phe Ser Trp 
            100                 105                 110         


Arg Gly Gly Ser Glu Arg Glu Thr Thr Gly Ile Gln Ile Trp Ser Glu 
        115                 120                 125             


Ile Phe Leu Ile Asn Lys Pro Asp Gly Lys Lys Val Ala Val Leu Leu 
    130                 135                 140                 


Met Asp Thr Gln Gly Thr Phe Asp Ser Gln Ser Thr Leu Arg Asp Ser 
145                 150                 155                 160 


Ala Thr Val Phe Ala Leu Ser Thr Met Ile Ser Ser Ile Gln Val Tyr 
                165                 170                 175     


Asn Leu Ser Gln Asn Val Gln Glu Asp Asp Leu Gln His Leu Gln Leu 
            180                 185                 190         


Phe Thr Glu Tyr Gly Arg Leu Ala Met Glu Glu Thr Phe Leu Lys Pro 
        195                 200                 205             


Phe Gln Ser Leu Ile Phe Leu Val Arg Asp Trp Ser Phe Pro Tyr Glu 
    210                 215                 220                 


Phe Ser Tyr Gly Ala Asp Gly Gly Ala Lys Phe Leu Glu Lys Arg Leu 
225                 230                 235                 240 


Lys Val Ser Gly Asn Gln His Glu Glu Leu Gln Asn Val Arg Lys His 
                245                 250                 255     


Ile His Ser Cys Phe Thr Asn Ile Ser Cys Phe Leu Leu Pro His Pro 
            260                 265                 270         


Gly Leu Lys Val Ala Thr Asn Pro Asn Phe Asp Gly Lys Leu Lys Glu 
        275                 280                 285             


Ile Asp Asp Glu Phe Ile Lys Asn Leu Lys Ile Leu Ile Pro Trp Leu 
    290                 295                 300                 


Leu Ser Pro Glu Ser Leu Asp Ile Lys Glu Ile Asn Gly Asn Lys Ile 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr 
                325                 330                 335     


Gln Gly Glu Glu Leu Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala 
            340                 345                 350         


Glu Ala Asn Asn Leu Ala Ala Val Ala Thr Ala Lys Asp Thr Tyr Asn 
        355                 360                 365             


Lys Lys Met Glu Glu Ile Cys Gly Gly Asp Lys Pro Phe Leu Ala Pro 
    370                 375                 380                 


Asn Asp Leu Gln Thr Lys His Leu Gln Leu Lys Glu Glu Ser Val Lys 
385                 390                 395                 400 


Leu Phe Arg Gly Val Lys Lys Met Gly Gly Glu Glu Phe Ser Arg Arg 
                405                 410                 415     


Tyr Leu Gln Gln Leu Glu Ser Glu Ile Asp Glu Leu Tyr Ile Gln Tyr 
            420                 425                 430         


Ile Lys His Asn Asp Ser Lys Asn Ile Phe His Ala Ala Arg Thr Pro 
        435                 440                 445             


Ala Thr Leu Phe Val Val Ile Phe Ile Thr Tyr Val Ile Ala Gly Val 
    450                 455                 460                 


Thr Gly Phe Ile Gly Leu Asp Ile Ile Ala Ser Leu Cys Asn Met Ile 
465                 470                 475                 480 


Met Gly Leu Thr Leu Ile Thr Leu Cys Thr Trp Ala Tyr Ile Arg Tyr 
                485                 490                 495     


Ser Gly Glu Tyr Arg Glu Leu Gly Ala Val Ile Asp Gln Val Ala Ala 
            500                 505                 510         


Ala Leu Trp Asp Gln Ala Leu Tyr Lys Leu Tyr Ser Ala Ala Ala Thr 
        515                 520                 525             


His Arg His Leu Tyr His Gln Ala Phe Pro Thr Pro Lys Ser Glu Ser 
    530                 535                 540                 


Thr Glu Gln Ser Glu Lys Lys Lys Met 
545                 550             


<210>  898
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATL2__Homo_sapiens__NP_001129145

<400>  898

Met Ala Glu Gly Asp Glu Ala Ala Arg Gly Gln Gln Pro His Gln Gly 
1               5                   10                  15      


Leu Trp Arg Arg Arg Arg Thr Ser Asp Pro Ser Ala Ala Val Asn His 
            20                  25                  30          


Val Ser Ser Thr Thr Ser Leu Gly Glu Asn Tyr Glu Asp Asp Asp Leu 
        35                  40                  45              


Val Asn Ser Asp Glu Val Met Lys Lys Pro Cys Pro Val Gln Ile Val 
    50                  55                  60                  


Leu Ala His Glu Asp Asp His Asn Phe Glu Leu Asp Glu Glu Ala Leu 
65                  70                  75                  80  


Glu Gln Ile Leu Leu Gln Glu His Ile Arg Asp Leu Asn Ile Val Val 
                85                  90                  95      


Val Ser Val Ala Gly Ala Phe Arg Lys Gly Lys Ser Phe Leu Leu Asp 
            100                 105                 110         


Phe Met Leu Arg Tyr Met Tyr Asn Lys Asp Ser Gln Ser Trp Ile Gly 
        115                 120                 125             


Gly Asn Asn Glu Pro Leu Thr Gly Phe Thr Trp Arg Gly Gly Cys Glu 
    130                 135                 140                 


Arg Glu Thr Thr Gly Ile Gln Val Trp Asn Glu Val Phe Val Ile Asp 
145                 150                 155                 160 


Arg Pro Asn Gly Thr Lys Val Ala Val Leu Leu Met Asp Thr Gln Gly 
                165                 170                 175     


Ala Phe Asp Ser Gln Ser Thr Ile Lys Asp Cys Ala Thr Val Phe Ala 
            180                 185                 190         


Leu Ser Thr Met Thr Ser Ser Val Gln Val Tyr Asn Leu Ser Gln Asn 
        195                 200                 205             


Ile Gln Glu Asp Asp Leu Gln His Leu Gln Leu Phe Thr Glu Tyr Gly 
    210                 215                 220                 


Arg Leu Ala Met Glu Glu Ile Tyr Gln Lys Pro Phe Gln Thr Leu Met 
225                 230                 235                 240 


Phe Leu Ile Arg Asp Trp Ser Tyr Pro Tyr Glu His Ser Tyr Gly Leu 
                245                 250                 255     


Glu Gly Gly Lys Gln Phe Leu Glu Lys Arg Leu Gln Val Lys Gln Asn 
            260                 265                 270         


Gln His Glu Glu Leu Gln Asn Val Arg Lys His Ile His Asn Cys Phe 
        275                 280                 285             


Ser Asn Leu Gly Cys Phe Leu Leu Pro His Pro Gly Leu Lys Val Ala 
    290                 295                 300                 


Thr Asn Pro Ser Phe Asp Gly Arg Leu Lys Asp Ile Asp Glu Asp Phe 
305                 310                 315                 320 


Lys Arg Glu Leu Arg Asn Leu Val Pro Leu Leu Leu Ala Pro Glu Asn 
                325                 330                 335     


Leu Val Glu Lys Glu Ile Ser Gly Ser Lys Val Thr Cys Arg Asp Leu 
            340                 345                 350         


Val Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr Gln Gly Glu Glu Leu 
        355                 360                 365             


Pro His Pro Lys Ser Met Leu Gln Ala Thr Ala Glu Ala Asn Asn Leu 
    370                 375                 380                 


Ala Ala Val Ala Gly Ala Arg Asp Thr Tyr Cys Lys Ser Met Glu Gln 
385                 390                 395                 400 


Val Cys Gly Gly Asp Lys Pro Tyr Ile Ala Pro Ser Asp Leu Glu Arg 
                405                 410                 415     


Lys His Leu Asp Leu Lys Glu Val Ala Ile Lys Gln Phe Arg Ser Val 
            420                 425                 430         


Lys Lys Met Gly Gly Asp Glu Phe Cys Arg Arg Tyr Gln Asp Gln Leu 
        435                 440                 445             


Glu Ala Glu Ile Glu Glu Thr Tyr Ala Asn Phe Ile Lys His Asn Asp 
    450                 455                 460                 


Gly Lys Asn Ile Phe Tyr Ala Ala Arg Thr Pro Ala Thr Leu Phe Ala 
465                 470                 475                 480 


Val Met Phe Ala Met Tyr Ile Ile Ser Gly Leu Thr Gly Phe Ile Gly 
                485                 490                 495     


Leu Asn Ser Ile Ala Val Leu Cys Asn Leu Val Met Gly Leu Ala Leu 
            500                 505                 510         


Ile Phe Leu Cys Thr Trp Ala Tyr Val Lys Tyr Ser Gly Glu Phe Arg 
        515                 520                 525             


Glu Ile Gly Thr Val Ile Asp Gln Ile Ala Glu Thr Leu Trp Glu Gln 
    530                 535                 540                 


Val Leu Lys Pro Leu Gly Asp Asn Leu Met Glu Glu Asn Ile Arg Gln 
545                 550                 555                 560 


Ser Val Thr Asn Ser Ile Lys Ala Gly Leu Thr Asp Gln Val Ser His 
                565                 570                 575     


His Ala Arg Leu Lys Thr Asp 
            580             


<210>  899
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATL3__Homo_sapiens__NP_001276977

<400>  899

Met Glu Ser Ser Lys Pro Gly Pro Val Gln Val Val Leu Val Gln Lys 
1               5                   10                  15      


Asp Gln His Ser Phe Glu Leu Asp Glu Lys Ala Leu Ala Ser Ile Leu 
            20                  25                  30          


Leu Gln Asp His Ile Arg Asp Leu Asp Val Val Val Val Ser Val Ala 
        35                  40                  45              


Gly Ala Phe Arg Lys Gly Lys Ser Phe Ile Leu Asp Phe Met Leu Arg 
    50                  55                  60                  


Tyr Leu Tyr Ser Gln Lys Glu Ser Gly His Ser Asn Trp Leu Gly Asp 
65                  70                  75                  80  


Pro Glu Glu Pro Leu Thr Gly Phe Ser Trp Arg Gly Gly Ser Asp Pro 
                85                  90                  95      


Glu Thr Thr Gly Ile Gln Ile Trp Ser Glu Val Phe Thr Val Glu Lys 
            100                 105                 110         


Pro Gly Gly Lys Lys Val Ala Val Val Leu Met Asp Thr Gln Gly Ala 
        115                 120                 125             


Phe Asp Ser Gln Ser Thr Val Lys Asp Cys Ala Thr Ile Phe Ala Leu 
    130                 135                 140                 


Ser Thr Met Thr Ser Ser Val Gln Ile Tyr Asn Leu Ser Gln Asn Ile 
145                 150                 155                 160 


Gln Glu Asp Asp Leu Gln Gln Leu Gln Leu Phe Thr Glu Tyr Gly Arg 
                165                 170                 175     


Leu Ala Met Asp Glu Ile Phe Gln Lys Pro Phe Gln Thr Leu Met Phe 
            180                 185                 190         


Leu Val Arg Asp Trp Ser Phe Pro Tyr Glu Tyr Ser Tyr Gly Leu Gln 
        195                 200                 205             


Gly Gly Met Ala Phe Leu Asp Lys Arg Leu Gln Val Lys Glu His Gln 
    210                 215                 220                 


His Glu Glu Ile Gln Asn Val Arg Asn His Ile His Ser Cys Phe Ser 
225                 230                 235                 240 


Asp Val Thr Cys Phe Leu Leu Pro His Pro Gly Leu Gln Val Ala Thr 
                245                 250                 255     


Ser Pro Asp Phe Asp Gly Lys Leu Lys Asp Ile Ala Gly Glu Phe Lys 
            260                 265                 270         


Glu Gln Leu Gln Ala Leu Ile Pro Tyr Val Leu Asn Pro Ser Lys Leu 
        275                 280                 285             


Met Glu Lys Glu Ile Asn Gly Ser Lys Val Thr Cys Arg Gly Leu Leu 
    290                 295                 300                 


Glu Tyr Phe Lys Ala Tyr Ile Lys Ile Tyr Gln Gly Glu Asp Leu Pro 
305                 310                 315                 320 


His Pro Lys Ser Met Leu Gln Ala Thr Ala Glu Ala Asn Asn Leu Ala 
                325                 330                 335     


Ala Ala Ala Ser Ala Lys Asp Ile Tyr Tyr Asn Asn Met Glu Glu Val 
            340                 345                 350         


Cys Gly Gly Glu Lys Pro Tyr Leu Ser Pro Asp Ile Leu Glu Glu Lys 
        355                 360                 365             


His Cys Glu Phe Lys Gln Leu Ala Leu Asp His Phe Lys Lys Thr Lys 
    370                 375                 380                 


Lys Met Gly Gly Lys Asp Phe Ser Phe Arg Tyr Gln Gln Glu Leu Glu 
385                 390                 395                 400 


Glu Glu Ile Lys Glu Leu Tyr Glu Asn Phe Cys Lys His Asn Gly Ser 
                405                 410                 415     


Lys Asn Val Phe Ser Thr Phe Arg Thr Pro Ala Val Leu Phe Thr Gly 
            420                 425                 430         


Ile Val Ala Leu Tyr Ile Ala Ser Gly Leu Thr Gly Phe Ile Gly Leu 
        435                 440                 445             


Glu Val Val Ala Gln Leu Phe Asn Cys Met Val Gly Leu Leu Leu Ile 
    450                 455                 460                 


Ala Leu Leu Thr Trp Gly Tyr Ile Arg Tyr Ser Gly Gln Tyr Arg Glu 
465                 470                 475                 480 


Leu Gly Gly Ala Ile Asp Phe Gly Ala Ala Tyr Val Leu Glu Gln Ala 
                485                 490                 495     


Ser Ser His Ile Gly Asn Ser Thr Gln Ala Thr Val Arg Asp Ala Val 
            500                 505                 510         


Val Gly Arg Pro Ser Met Asp Lys Lys Ala Gln 
        515                 520             


<210>  900
<211>  3056
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATM__Homo_sapiens__XP_006718906

<400>  900

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  901
<211>  1190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATN1__Homo_sapiens__NP_001007027

<400>  901

Met Lys Thr Arg Gln Asn Lys Asp Ser Met Ser Met Arg Ser Gly Arg 
1               5                   10                  15      


Lys Lys Glu Ala Pro Gly Pro Arg Glu Glu Leu Arg Ser Arg Gly Arg 
            20                  25                  30          


Ala Ser Pro Gly Gly Val Ser Thr Ser Ser Ser Asp Gly Lys Ala Glu 
        35                  40                  45              


Lys Ser Arg Gln Thr Ala Lys Lys Ala Arg Val Glu Glu Ala Ser Thr 
    50                  55                  60                  


Pro Lys Val Asn Lys Gln Gly Arg Ser Glu Glu Ile Ser Glu Ser Glu 
65                  70                  75                  80  


Ser Glu Glu Thr Asn Ala Pro Lys Lys Thr Lys Thr Glu Gln Glu Leu 
                85                  90                  95      


Pro Arg Pro Gln Ser Pro Ser Asp Leu Asp Ser Leu Asp Gly Arg Ser 
            100                 105                 110         


Leu Asn Asp Asp Gly Ser Ser Asp Pro Arg Asp Ile Asp Gln Asp Asn 
        115                 120                 125             


Arg Ser Thr Ser Pro Ser Ile Tyr Ser Pro Gly Ser Val Glu Asn Asp 
    130                 135                 140                 


Ser Asp Ser Ser Ser Gly Leu Ser Gln Gly Pro Ala Arg Pro Tyr His 
145                 150                 155                 160 


Pro Pro Pro Leu Phe Pro Pro Ser Pro Gln Pro Pro Asp Ser Thr Pro 
                165                 170                 175     


Arg Gln Pro Glu Ala Ser Phe Glu Pro His Pro Ser Val Thr Pro Thr 
            180                 185                 190         


Gly Tyr His Ala Pro Met Glu Pro Pro Thr Ser Arg Met Phe Gln Ala 
        195                 200                 205             


Pro Pro Gly Ala Pro Pro Pro His Pro Gln Leu Tyr Pro Gly Gly Thr 
    210                 215                 220                 


Gly Gly Val Leu Ser Gly Pro Pro Met Gly Pro Lys Gly Gly Gly Ala 
225                 230                 235                 240 


Ala Ser Ser Val Gly Gly Pro Asn Gly Gly Lys Gln His Pro Pro Pro 
                245                 250                 255     


Thr Thr Pro Ile Ser Val Ser Ser Ser Gly Ala Ser Gly Ala Pro Pro 
            260                 265                 270         


Thr Lys Pro Pro Thr Thr Pro Val Gly Gly Gly Asn Leu Pro Ser Ala 
        275                 280                 285             


Pro Pro Pro Ala Asn Phe Pro His Val Thr Pro Asn Leu Pro Pro Pro 
    290                 295                 300                 


Pro Ala Leu Arg Pro Leu Asn Asn Ala Ser Ala Ser Pro Pro Gly Leu 
305                 310                 315                 320 


Gly Ala Gln Pro Leu Pro Gly His Leu Pro Ser Pro His Ala Met Gly 
                325                 330                 335     


Gln Gly Met Gly Gly Leu Pro Pro Gly Pro Glu Lys Gly Pro Thr Leu 
            340                 345                 350         


Ala Pro Ser Pro His Ser Leu Pro Pro Ala Ser Ser Ser Ala Pro Ala 
        355                 360                 365             


Pro Pro Met Arg Phe Pro Tyr Ser Ser Ser Ser Ser Ser Ser Ala Ala 
    370                 375                 380                 


Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser Pro Phe Pro 
385                 390                 395                 400 


Ala Ser Gln Ala Leu Pro Ser Tyr Pro His Ser Phe Pro Pro Pro Thr 
                405                 410                 415     


Ser Leu Ser Val Ser Asn Gln Pro Pro Lys Tyr Thr Gln Pro Ser Leu 
            420                 425                 430         


Pro Ser Gln Ala Val Trp Ser Gln Gly Pro Pro Pro Pro Pro Pro Tyr 
        435                 440                 445             


Gly Arg Leu Leu Ala Asn Ser Asn Ala His Pro Gly Pro Phe Pro Pro 
    450                 455                 460                 


Ser Thr Gly Ala Gln Ser Thr Ala His Pro Pro Val Ser Thr His His 
465                 470                 475                 480 


His His His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                485                 490                 495     


Gln Gln Gln Gln Gln Gln His His Gly Asn Ser Gly Pro Pro Pro Pro 
            500                 505                 510         


Gly Ala Phe Pro His Pro Leu Glu Gly Gly Ser Ser His His Ala His 
        515                 520                 525             


Pro Tyr Ala Met Ser Pro Ser Leu Gly Ser Leu Arg Pro Tyr Pro Pro 
    530                 535                 540                 


Gly Pro Ala His Leu Pro Pro Pro His Ser Gln Val Ser Tyr Ser Gln 
545                 550                 555                 560 


Ala Gly Pro Asn Gly Pro Pro Val Ser Ser Ser Ser Asn Ser Ser Ser 
                565                 570                 575     


Ser Thr Ser Gln Gly Ser Tyr Pro Cys Ser His Pro Ser Pro Ser Gln 
            580                 585                 590         


Gly Pro Gln Gly Ala Pro Tyr Pro Phe Pro Pro Val Pro Thr Val Thr 
        595                 600                 605             


Thr Ser Ser Ala Thr Leu Ser Thr Val Ile Ala Thr Val Ala Ser Ser 
    610                 615                 620                 


Pro Ala Gly Tyr Lys Thr Ala Ser Pro Pro Gly Pro Pro Pro Tyr Gly 
625                 630                 635                 640 


Lys Arg Ala Pro Ser Pro Gly Ala Tyr Lys Thr Ala Thr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Pro Gly Ser Pro Pro Ser Phe Arg Thr Gly Thr Pro Pro Gly 
            660                 665                 670         


Tyr Arg Gly Thr Ser Pro Pro Ala Gly Pro Gly Thr Phe Lys Pro Gly 
        675                 680                 685             


Ser Pro Thr Val Gly Pro Gly Pro Leu Pro Pro Ala Gly Pro Ser Gly 
    690                 695                 700                 


Leu Pro Ser Leu Pro Pro Pro Pro Ala Ala Pro Ala Ser Gly Pro Pro 
705                 710                 715                 720 


Leu Ser Ala Thr Gln Ile Lys Gln Glu Pro Ala Glu Glu Tyr Glu Thr 
                725                 730                 735     


Pro Glu Ser Pro Val Pro Pro Ala Arg Ser Pro Ser Pro Pro Pro Lys 
            740                 745                 750         


Val Val Asp Val Pro Ser His Ala Ser Gln Ser Ala Arg Phe Asn Lys 
        755                 760                 765             


His Leu Asp Arg Gly Phe Asn Ser Cys Ala Arg Ser Asp Leu Tyr Phe 
    770                 775                 780                 


Val Pro Leu Glu Gly Ser Lys Leu Ala Lys Lys Arg Ala Asp Leu Val 
785                 790                 795                 800 


Glu Lys Val Arg Arg Glu Ala Glu Gln Arg Ala Arg Glu Glu Lys Glu 
                805                 810                 815     


Arg Glu Arg Glu Arg Glu Arg Glu Lys Glu Arg Glu Arg Glu Lys Glu 
            820                 825                 830         


Arg Glu Leu Glu Arg Ser Val Lys Leu Ala Gln Glu Gly Arg Ala Pro 
        835                 840                 845             


Val Glu Cys Pro Ser Leu Gly Pro Val Pro His Arg Pro Pro Phe Glu 
    850                 855                 860                 


Pro Gly Ser Ala Val Ala Thr Val Pro Pro Tyr Leu Gly Pro Asp Thr 
865                 870                 875                 880 


Pro Ala Leu Arg Thr Leu Ser Glu Tyr Ala Arg Pro His Val Met Ser 
                885                 890                 895     


Pro Gly Asn Arg Asn His Pro Phe Tyr Val Pro Leu Gly Ala Val Asp 
            900                 905                 910         


Pro Gly Leu Leu Gly Tyr Asn Val Pro Ala Leu Tyr Ser Ser Asp Pro 
        915                 920                 925             


Ala Ala Arg Glu Arg Glu Arg Glu Ala Arg Glu Arg Asp Leu Arg Asp 
    930                 935                 940                 


Arg Leu Lys Pro Gly Phe Glu Val Lys Pro Ser Glu Leu Glu Pro Leu 
945                 950                 955                 960 


His Gly Val Pro Gly Pro Gly Leu Asp Pro Phe Pro Arg His Gly Gly 
                965                 970                 975     


Leu Ala Leu Gln Pro Gly Pro Pro Gly Leu His Pro Phe Pro Phe His 
            980                 985                 990         


Pro Ser Leu Gly Pro Leu Glu Arg  Glu Arg Leu Ala Leu  Ala Ala Gly 
        995                 1000                 1005             


Pro Ala  Leu Arg Pro Asp Met  Ser Tyr Ala Glu Arg  Leu Ala Ala 
    1010                 1015                 1020             


Glu Arg  Gln His Ala Glu Arg  Val Ala Ala Leu Gly  Asn Asp Pro 
    1025                 1030                 1035             


Leu Ala  Arg Leu Gln Met Leu  Asn Val Thr Pro His  His His Gln 
    1040                 1045                 1050             


His Ser  His Ile His Ser His  Leu His Leu His Gln  Gln Asp Ala 
    1055                 1060                 1065             


Ile His  Ala Ala Ser Ala Ser  Val His Pro Leu Ile  Asp Pro Leu 
    1070                 1075                 1080             


Ala Ser  Gly Ser His Leu Thr  Arg Ile Pro Tyr Pro  Ala Gly Thr 
    1085                 1090                 1095             


Leu Pro  Asn Pro Leu Leu Pro  His Pro Leu His Glu  Asn Glu Val 
    1100                 1105                 1110             


Leu Arg  His Gln Leu Phe Ala  Ala Pro Tyr Arg Asp  Leu Pro Ala 
    1115                 1120                 1125             


Ser Leu  Ser Ala Pro Met Ser  Ala Ala His Gln Leu  Gln Ala Met 
    1130                 1135                 1140             


His Ala  Gln Ser Ala Glu Leu  Gln Arg Leu Ala Leu  Glu Gln Gln 
    1145                 1150                 1155             


Gln Trp  Leu His Ala His His  Pro Leu His Ser Val  Pro Leu Pro 
    1160                 1165                 1170             


Ala Gln  Glu Asp Tyr Tyr Ser  His Leu Lys Lys Glu  Ser Asp Lys 
    1175                 1180                 1185             


Pro Leu  
    1190 


<210>  902
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATOH1__Homo_sapiens__NP_005163

<400>  902

Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 
1               5                   10                  15      


Gly Asp His His Arg Gln Pro Gln Pro His His Leu Pro Gln Pro Pro 
            20                  25                  30          


Pro Pro Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Glu His Pro Val 
        35                  40                  45              


Tyr Pro Pro Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp 
    50                  55                  60                  


Leu Ala Pro Thr Leu Gln Gly Ile Cys Thr Ala Arg Ala Ala Gln Tyr 
65                  70                  75                  80  


Leu Leu His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg 
                85                  90                  95      


Asp Glu Val Asp Gly Arg Gly Glu Leu Val Arg Arg Ser Ser Gly Gly 
            100                 105                 110         


Ala Ser Ser Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu 
        115                 120                 125             


Cys Lys Leu Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg 
    130                 135                 140                 


Gln Arg Ala Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg 
145                 150                 155                 160 


Arg Leu Ala Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn 
                165                 170                 175     


His Ala Phe Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp 
            180                 185                 190         


Lys Lys Leu Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile 
        195                 200                 205             


Asn Ala Leu Ser Glu Leu Leu Gln Thr Pro Ser Gly Gly Glu Gln Pro 
    210                 215                 220                 


Pro Pro Pro Pro Ala Ser Cys Lys Ser Asp His His His Leu Arg Thr 
225                 230                 235                 240 


Ala Ala Ser Tyr Glu Gly Gly Ala Gly Asn Ala Thr Ala Ala Gly Ala 
                245                 250                 255     


Gln Gln Ala Ser Gly Gly Ser Gln Arg Pro Thr Pro Pro Gly Ser Cys 
            260                 265                 270         


Arg Thr Arg Phe Ser Ala Pro Ala Ser Ala Gly Gly Tyr Ser Val Gln 
        275                 280                 285             


Leu Asp Ala Leu His Phe Ser Thr Phe Glu Asp Ser Ala Leu Thr Ala 
    290                 295                 300                 


Met Met Ala Gln Lys Asn Leu Ser Pro Ser Leu Pro Gly Ser Ile Leu 
305                 310                 315                 320 


Gln Pro Val Gln Glu Glu Asn Ser Lys Thr Ser Pro Arg Ser His Arg 
                325                 330                 335     


Ser Asp Gly Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu 
            340                 345                 350         


Ala Ser 
        


<210>  903
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATOH7__Homo_sapiens__NP_660161

<400>  903

Met Lys Ser Cys Lys Pro Ser Gly Pro Pro Ala Gly Ala Arg Val Ala 
1               5                   10                  15      


Pro Pro Cys Ala Gly Gly Thr Glu Cys Ala Gly Thr Cys Ala Gly Ala 
            20                  25                  30          


Gly Arg Leu Glu Ser Ala Ala Arg Arg Arg Leu Ala Ala Asn Ala Arg 
        35                  40                  45              


Glu Arg Arg Arg Met Gln Gly Leu Asn Thr Ala Phe Asp Arg Leu Arg 
    50                  55                  60                  


Arg Val Val Pro Gln Trp Gly Gln Asp Lys Lys Leu Ser Lys Tyr Glu 
65                  70                  75                  80  


Thr Leu Gln Met Ala Leu Ser Tyr Ile Met Ala Leu Thr Arg Ile Leu 
                85                  90                  95      


Ala Glu Ala Glu Arg Phe Gly Ser Glu Arg Asp Trp Val Gly Leu His 
            100                 105                 110         


Cys Glu His Phe Gly Arg Asp His Tyr Leu Pro Phe Pro Gly Ala Lys 
        115                 120                 125             


Leu Pro Gly Glu Ser Glu Leu Tyr Ser Gln Arg Leu Phe Gly Phe Gln 
    130                 135                 140                 


Pro Glu Pro Phe Gln Met Ala Thr 
145                 150         


<210>  904
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATOX1__Homo_sapiens__NP_004036

<400>  904

Met Pro Lys His Glu Phe Ser Val Asp Met Thr Cys Gly Gly Cys Ala 
1               5                   10                  15      


Glu Ala Val Ser Arg Val Leu Asn Lys Leu Gly Gly Val Lys Tyr Asp 
            20                  25                  30          


Ile Asp Leu Pro Asn Lys Lys Val Cys Ile Glu Ser Glu His Ser Met 
        35                  40                  45              


Asp Thr Leu Leu Ala Thr Leu Lys Lys Thr Gly Lys Thr Val Ser Tyr 
    50                  55                  60                  


Leu Gly Leu Glu 
65              


<210>  905
<211>  1499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP10A__Homo_sapiens__NP_077816

<400>  905

Met Glu Arg Glu Pro Ala Gly Thr Glu Glu Pro Gly Pro Pro Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Glu Gly Arg Thr Arg Thr Val Arg Ser Asn Leu Leu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Asp Pro Ala Ala Gly Ala Ala Lys Gly Glu 
        35                  40                  45              


Arg Arg Arg Arg Arg Gly Cys Ala Gln His Leu Ala Asp Asn Arg Leu 
    50                  55                  60                  


Lys Thr Thr Lys Tyr Thr Leu Leu Ser Phe Leu Pro Lys Asn Leu Phe 
65                  70                  75                  80  


Glu Gln Phe His Arg Pro Ala Asn Val Tyr Phe Val Phe Ile Ala Leu 
                85                  90                  95      


Leu Asn Phe Val Pro Ala Val Asn Ala Phe Gln Pro Gly Leu Ala Leu 
            100                 105                 110         


Ala Pro Val Leu Phe Ile Leu Ala Ile Thr Ala Phe Arg Asp Leu Trp 
        115                 120                 125             


Glu Asp Tyr Ser Arg His Arg Ser Asp His Lys Ile Asn His Leu Gly 
    130                 135                 140                 


Cys Leu Val Phe Ser Arg Glu Glu Lys Lys Tyr Val Asn Arg Phe Trp 
145                 150                 155                 160 


Lys Glu Ile His Val Gly Asp Phe Val Arg Leu Arg Cys Asn Glu Ile 
                165                 170                 175     


Phe Pro Ala Asp Ile Leu Leu Leu Ser Ser Ser Asp Pro Asp Gly Leu 
            180                 185                 190         


Cys His Ile Glu Thr Ala Asn Leu Asp Gly Glu Thr Asn Leu Lys Arg 
        195                 200                 205             


Arg Gln Val Val Arg Gly Phe Ser Glu Leu Val Ser Glu Phe Asn Pro 
    210                 215                 220                 


Leu Thr Phe Thr Ser Val Ile Glu Cys Glu Lys Pro Asn Asn Asp Leu 
225                 230                 235                 240 


Ser Arg Phe Arg Gly Cys Ile Ile His Asp Asn Gly Lys Lys Ala Gly 
                245                 250                 255     


Leu Tyr Lys Glu Asn Leu Leu Leu Arg Gly Cys Thr Leu Arg Asn Thr 
            260                 265                 270         


Asp Ala Val Val Gly Ile Val Ile Tyr Ala Gly His Glu Thr Lys Ala 
        275                 280                 285             


Leu Leu Asn Asn Ser Gly Pro Arg Tyr Lys Arg Ser Lys Leu Glu Arg 
    290                 295                 300                 


Gln Met Asn Cys Asp Val Leu Trp Cys Val Leu Leu Leu Val Cys Met 
305                 310                 315                 320 


Ser Leu Phe Ser Ala Val Gly His Gly Leu Trp Ile Trp Arg Tyr Gln 
                325                 330                 335     


Glu Lys Lys Ser Leu Phe Tyr Val Pro Lys Ser Asp Gly Ser Ser Leu 
            340                 345                 350         


Ser Pro Val Thr Ala Ala Val Tyr Ser Phe Leu Thr Met Ile Ile Val 
        355                 360                 365             


Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr Val Ser Ile Glu Ile Val 
    370                 375                 380                 


Lys Ala Cys Gln Val Tyr Phe Ile Asn Gln Asp Met Gln Leu Tyr Asp 
385                 390                 395                 400 


Glu Glu Thr Asp Ser Gln Leu Gln Cys Arg Ala Leu Asn Ile Thr Glu 
                405                 410                 415     


Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu 
            420                 425                 430         


Thr Glu Asn Lys Met Val Phe Arg Arg Cys Thr Val Ser Gly Val Glu 
        435                 440                 445             


Tyr Ser His Asp Ala Asn Ala Gln Arg Leu Ala Arg Tyr Gln Glu Ala 
    450                 455                 460                 


Asp Ser Glu Glu Glu Glu Val Val Pro Arg Gly Gly Ser Val Ser Gln 
465                 470                 475                 480 


Arg Gly Ser Ile Gly Ser His Gln Ser Val Arg Val Val His Arg Thr 
                485                 490                 495     


Gln Ser Thr Lys Ser His Arg Arg Thr Gly Ser Arg Ala Glu Ala Lys 
            500                 505                 510         


Arg Ala Ser Met Leu Ser Lys His Thr Ala Phe Ser Ser Pro Met Glu 
        515                 520                 525             


Lys Asp Ile Thr Pro Asp Pro Lys Leu Leu Glu Lys Val Ser Glu Cys 
    530                 535                 540                 


Asp Lys Ser Leu Ala Val Ala Arg His Gln Glu His Leu Leu Ala His 
545                 550                 555                 560 


Leu Ser Pro Glu Leu Ser Asp Val Phe Asp Phe Phe Ile Ala Leu Thr 
                565                 570                 575     


Ile Cys Asn Thr Val Val Val Thr Ser Pro Asp Gln Pro Arg Thr Lys 
            580                 585                 590         


Val Arg Val Arg Phe Glu Leu Lys Ser Pro Val Lys Thr Ile Glu Asp 
        595                 600                 605             


Phe Leu Arg Arg Phe Thr Pro Ser Cys Leu Thr Ser Gly Cys Ser Ser 
    610                 615                 620                 


Ile Gly Ser Leu Ala Ala Asn Lys Ser Ser His Lys Leu Gly Ser Ser 
625                 630                 635                 640 


Phe Pro Ser Thr Pro Ser Ser Asp Gly Met Leu Leu Arg Leu Glu Glu 
                645                 650                 655     


Arg Leu Gly Gln Pro Thr Ser Ala Ile Ala Ser Asn Gly Tyr Ser Ser 
            660                 665                 670         


Gln Ala Asp Asn Trp Ala Ser Glu Leu Ala Gln Glu Gln Glu Ser Glu 
        675                 680                 685             


Arg Glu Leu Arg Tyr Glu Ala Glu Ser Pro Asp Glu Ala Ala Leu Val 
    690                 695                 700                 


Tyr Ala Ala Arg Ala Tyr Asn Cys Val Leu Val Glu Arg Leu His Asp 
705                 710                 715                 720 


Gln Val Ser Val Glu Leu Pro His Leu Gly Arg Leu Thr Phe Glu Leu 
                725                 730                 735     


Leu His Thr Leu Gly Phe Asp Ser Val Arg Lys Arg Met Ser Val Val 
            740                 745                 750         


Ile Arg His Pro Leu Thr Asp Glu Ile Asn Val Tyr Thr Lys Gly Ala 
        755                 760                 765             


Asp Ser Val Val Met Asp Leu Leu Gln Pro Cys Ser Ser Val Asp Ala 
    770                 775                 780                 


Arg Gly Arg His Gln Lys Lys Ile Arg Ser Lys Thr Gln Asn Tyr Leu 
785                 790                 795                 800 


Asn Val Tyr Ala Ala Glu Gly Leu Arg Thr Leu Cys Ile Ala Lys Arg 
                805                 810                 815     


Val Leu Ser Lys Glu Glu Tyr Ala Cys Trp Leu Gln Ser His Leu Glu 
            820                 825                 830         


Ala Glu Ser Ser Leu Glu Asn Ser Glu Glu Leu Leu Phe Gln Ser Ala 
        835                 840                 845             


Ile Arg Leu Glu Thr Asn Leu His Leu Leu Gly Ala Thr Gly Ile Glu 
    850                 855                 860                 


Asp Arg Leu Gln Asp Gly Val Pro Glu Thr Ile Ser Lys Leu Arg Gln 
865                 870                 875                 880 


Ala Gly Leu Gln Ile Trp Val Leu Thr Gly Asp Lys Gln Glu Thr Ala 
                885                 890                 895     


Val Asn Ile Ala Tyr Ala Cys Lys Leu Leu Asp His Asp Glu Glu Val 
            900                 905                 910         


Ile Thr Leu Asn Ala Thr Ser Gln Glu Ala Cys Ala Ala Leu Leu Asp 
        915                 920                 925             


Gln Cys Leu Cys Tyr Val Gln Ser Arg Gly Leu Gln Arg Ala Pro Glu 
    930                 935                 940                 


Lys Thr Lys Gly Lys Val Ser Met Arg Phe Ser Ser Leu Cys Pro Pro 
945                 950                 955                 960 


Ser Thr Ser Thr Ala Ser Gly Arg Arg Pro Ser Leu Val Ile Asp Gly 
                965                 970                 975     


Arg Ser Leu Ala Tyr Ala Leu Glu Lys Asn Leu Glu Asp Lys Phe Leu 
            980                 985                 990         


Phe Leu Ala Lys Gln Cys Arg Ser  Val Leu Cys Cys Arg  Ser Thr Pro 
        995                 1000                 1005             


Leu Gln  Lys Ser Met Val Val  Lys Leu Val Arg Ser  Lys Leu Lys 
    1010                 1015                 1020             


Ala Met  Thr Leu Ala Ile Gly  Asp Gly Ala Asn Asp  Val Ser Met 
    1025                 1030                 1035             


Ile Gln  Val Ala Asp Val Gly  Val Gly Ile Ser Gly  Gln Glu Gly 
    1040                 1045                 1050             


Met Gln  Ala Val Met Ala Ser  Asp Phe Ala Val Pro  Lys Phe Arg 
    1055                 1060                 1065             


Tyr Leu  Glu Arg Leu Leu Ile  Leu His Gly His Trp  Cys Tyr Ser 
    1070                 1075                 1080             


Arg Leu  Ala Asn Met Val Leu  Tyr Phe Phe Tyr Lys  Asn Thr Met 
    1085                 1090                 1095             


Phe Val  Gly Leu Leu Phe Trp  Phe Gln Phe Phe Cys  Gly Phe Ser 
    1100                 1105                 1110             


Ala Ser  Thr Met Ile Asp Gln  Trp Tyr Leu Ile Phe  Phe Asn Leu 
    1115                 1120                 1125             


Leu Phe  Ser Ser Leu Pro Pro  Leu Val Thr Gly Val  Leu Asp Arg 
    1130                 1135                 1140             


Asp Val  Pro Ala Asn Val Leu  Leu Thr Asn Pro Gln  Leu Tyr Lys 
    1145                 1150                 1155             


Ser Gly  Gln Asn Met Glu Glu  Tyr Arg Pro Arg Thr  Phe Trp Phe 
    1160                 1165                 1170             


Asn Met  Ala Asp Ala Ala Phe  Gln Ser Leu Val Cys  Phe Ser Ile 
    1175                 1180                 1185             


Pro Tyr  Leu Ala Tyr Tyr Asp  Ser Asn Val Asp Leu  Phe Thr Trp 
    1190                 1195                 1200             


Gly Thr  Pro Ile Val Thr Ile  Ala Leu Leu Thr Phe  Leu Leu His 
    1205                 1210                 1215             


Leu Gly  Ile Glu Thr Lys Thr  Trp Thr Trp Leu Asn  Trp Ile Thr 
    1220                 1225                 1230             


Cys Gly  Phe Ser Val Leu Leu  Phe Phe Thr Val Ala  Leu Ile Tyr 
    1235                 1240                 1245             


Asn Ala  Ser Cys Ala Thr Cys  Tyr Pro Pro Ser Asn  Pro Tyr Trp 
    1250                 1255                 1260             


Thr Met  Gln Ala Leu Leu Gly  Asp Pro Val Phe Tyr  Leu Thr Cys 
    1265                 1270                 1275             


Leu Met  Thr Pro Val Ala Ala  Leu Leu Pro Arg Leu  Phe Phe Arg 
    1280                 1285                 1290             


Ser Leu  Gln Gly Arg Val Phe  Pro Thr Gln Leu Gln  Leu Ala Arg 
    1295                 1300                 1305             


Gln Leu  Thr Arg Lys Ser Pro  Arg Arg Cys Ser Ala  Pro Lys Glu 
    1310                 1315                 1320             


Thr Phe  Ala Gln Gly Arg Leu  Pro Lys Asp Ser Gly  Thr Glu His 
    1325                 1330                 1335             


Ser Ser  Gly Arg Thr Val Lys  Thr Ser Val Pro Leu  Ser Gln Pro 
    1340                 1345                 1350             


Ser Trp  His Thr Gln Gln Pro  Val Cys Ser Leu Glu  Ala Ser Gly 
    1355                 1360                 1365             


Glu Pro  Ser Thr Val Asp Met  Ser Met Pro Val Arg  Glu His Thr 
    1370                 1375                 1380             


Leu Leu  Glu Gly Leu Ser Ala  Pro Ala Pro Met Ser  Ser Ala Pro 
    1385                 1390                 1395             


Gly Glu  Ala Val Leu Arg Ser  Pro Gly Gly Cys Pro  Glu Glu Ser 
    1400                 1405                 1410             


Lys Val  Arg Ala Ala Ser Thr  Gly Arg Val Thr Pro  Leu Ser Ser 
    1415                 1420                 1425             


Leu Phe  Ser Leu Pro Thr Phe  Ser Leu Leu Asn Trp  Ile Ser Ser 
    1430                 1435                 1440             


Trp Ser  Leu Val Ser Arg Leu  Gly Ser Val Leu Gln  Phe Ser Arg 
    1445                 1450                 1455             


Thr Glu  Gln Leu Ala Asp Gly  Gln Ala Gly Arg Gly  Leu Pro Val 
    1460                 1465                 1470             


Gln Pro  His Ser Gly Arg Ser  Gly Leu Gln Gly Pro  Asp His Arg 
    1475                 1480                 1485             


Leu Leu  Ile Gly Ala Ser Ser  Arg Arg Ser Gln 
    1490                 1495                 


<210>  906
<211>  1461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP10B__Homo_sapiens__NP_079429

<400>  906

Met Ala Leu Ser Val Asp Ser Ser Trp His Arg Trp Gln Trp Arg Val 
1               5                   10                  15      


Arg Asp Gly Phe Pro His Cys Pro Ser Glu Thr Thr Pro Leu Leu Ser 
            20                  25                  30          


Pro Glu Lys Gly Arg Gln Ser Tyr Asn Leu Thr Gln Gln Arg Val Val 
        35                  40                  45              


Phe Pro Asn Asn Ser Ile Phe His Gln Asp Trp Glu Glu Val Ser Arg 
    50                  55                  60                  


Arg Tyr Pro Gly Asn Arg Thr Cys Thr Thr Lys Tyr Thr Leu Phe Thr 
65                  70                  75                  80  


Phe Leu Pro Arg Asn Leu Phe Glu Gln Phe His Arg Trp Ala Asn Leu 
                85                  90                  95      


Tyr Phe Leu Phe Leu Val Ile Leu Asn Trp Met Pro Ser Met Glu Val 
            100                 105                 110         


Phe His Arg Glu Ile Thr Met Leu Pro Leu Ala Ile Val Leu Phe Val 
        115                 120                 125             


Ile Met Ile Lys Asp Gly Met Glu Asp Phe Lys Arg His Arg Phe Asp 
    130                 135                 140                 


Lys Ala Ile Asn Cys Ser Asn Ile Arg Ile Tyr Glu Arg Lys Glu Gln 
145                 150                 155                 160 


Thr Tyr Val Gln Lys Cys Trp Lys Asp Val Arg Val Gly Asp Phe Ile 
                165                 170                 175     


Gln Met Lys Cys Asn Glu Ile Val Pro Ala Asp Ile Leu Leu Leu Phe 
            180                 185                 190         


Ser Ser Asp Pro Asn Gly Ile Cys His Leu Glu Thr Ala Ser Leu Asp 
        195                 200                 205             


Gly Glu Thr Asn Leu Lys Gln Arg Cys Val Val Lys Gly Phe Ser Gln 
    210                 215                 220                 


Gln Glu Val Gln Phe Glu Pro Glu Leu Phe His Asn Thr Ile Val Cys 
225                 230                 235                 240 


Glu Lys Pro Asn Asn His Leu Asn Lys Phe Lys Gly Tyr Met Glu His 
                245                 250                 255     


Pro Asp Gln Thr Arg Thr Gly Phe Gly Cys Glu Ser Leu Leu Leu Arg 
            260                 265                 270         


Gly Cys Thr Ile Arg Asn Thr Glu Met Ala Val Gly Ile Val Ile Tyr 
        275                 280                 285             


Ala Gly His Glu Thr Lys Ala Met Leu Asn Asn Ser Gly Pro Arg Tyr 
    290                 295                 300                 


Lys Arg Ser Lys Ile Glu Arg Arg Met Asn Ile Asp Ile Phe Phe Cys 
305                 310                 315                 320 


Ile Gly Ile Leu Ile Leu Met Cys Leu Ile Gly Ala Val Gly His Ser 
                325                 330                 335     


Ile Trp Asn Gly Thr Phe Glu Glu His Pro Pro Phe Asp Val Pro Asp 
            340                 345                 350         


Ala Asn Gly Ser Phe Leu Pro Ser Ala Leu Gly Gly Phe Tyr Met Phe 
        355                 360                 365             


Leu Thr Met Ile Ile Leu Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr 
    370                 375                 380                 


Val Ser Ile Glu Leu Val Lys Leu Gly Gln Val Phe Phe Leu Ser Asn 
385                 390                 395                 400 


Asp Leu Asp Leu Tyr Asp Glu Glu Thr Asp Leu Ser Ile Gln Cys Arg 
                405                 410                 415     


Ala Leu Asn Ile Ala Glu Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser 
            420                 425                 430         


Asp Lys Thr Gly Thr Leu Thr Glu Asn Lys Met Val Phe Arg Arg Cys 
        435                 440                 445             


Thr Ile Met Gly Ser Glu Tyr Ser His Gln Glu Asn Ala Lys Arg Leu 
    450                 455                 460                 


Glu Thr Pro Lys Glu Leu Asp Ser Asp Gly Glu Glu Trp Thr Gln Tyr 
465                 470                 475                 480 


Gln Cys Leu Ser Phe Ser Ala Arg Trp Ala Gln Asp Pro Ala Thr Met 
                485                 490                 495     


Arg Ser Gln Lys Gly Ala Gln Pro Leu Arg Arg Ser Gln Ser Ala Arg 
            500                 505                 510         


Val Pro Ile Gln Gly His Tyr Arg Gln Arg Ser Met Gly His Arg Glu 
        515                 520                 525             


Ser Ser Gln Pro Pro Val Ala Phe Ser Ser Ser Ile Glu Lys Asp Val 
    530                 535                 540                 


Thr Pro Asp Lys Asn Leu Leu Thr Lys Val Arg Asp Ala Ala Leu Trp 
545                 550                 555                 560 


Leu Glu Thr Leu Ser Asp Ser Arg Pro Ala Lys Ala Ser Leu Ser Thr 
                565                 570                 575     


Thr Ser Ser Ile Ala Asp Phe Phe Leu Ala Leu Thr Ile Cys Asn Ser 
            580                 585                 590         


Val Met Val Ser Thr Thr Thr Glu Pro Arg Gln Arg Val Thr Ile Lys 
        595                 600                 605             


Pro Ser Ser Lys Ala Leu Gly Thr Ser Leu Glu Lys Ile Gln Gln Leu 
    610                 615                 620                 


Phe Gln Lys Leu Lys Leu Leu Ser Leu Ser Gln Ser Phe Ser Ser Thr 
625                 630                 635                 640 


Ala Pro Ser Asp Thr Asp Leu Gly Glu Ser Leu Gly Ala Asn Val Ala 
                645                 650                 655     


Thr Thr Asp Ser Asp Glu Arg Asp Asp Ala Ser Val Cys Ser Gly Gly 
            660                 665                 670         


Asp Ser Thr Asp Asp Gly Gly Tyr Arg Ser Ser Met Trp Asp Gln Gly 
        675                 680                 685             


Asp Ile Leu Glu Ser Gly Ser Gly Thr Ser Leu Glu Glu Ala Leu Glu 
    690                 695                 700                 


Ala Pro Ala Thr Asp Leu Ala Arg Pro Glu Phe Cys Tyr Glu Ala Glu 
705                 710                 715                 720 


Ser Pro Asp Glu Ala Ala Leu Val His Ala Ala His Ala Tyr Ser Phe 
                725                 730                 735     


Thr Leu Val Ser Arg Thr Pro Glu Gln Val Thr Val Arg Leu Pro Gln 
            740                 745                 750         


Gly Thr Cys Leu Thr Phe Ser Leu Leu Cys Thr Leu Gly Phe Asp Ser 
        755                 760                 765             


Val Arg Lys Arg Met Ser Val Val Val Arg His Pro Leu Thr Gly Glu 
    770                 775                 780                 


Ile Val Val Tyr Thr Lys Gly Ala Asp Ser Val Ile Met Asp Leu Leu 
785                 790                 795                 800 


Glu Asp Pro Ala Cys Val Pro Asp Ile Asn Met Glu Lys Lys Leu Arg 
                805                 810                 815     


Lys Ile Arg Ala Arg Thr Gln Lys His Leu Asp Leu Tyr Ala Arg Asp 
            820                 825                 830         


Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val Val Ser Glu Glu Asp 
        835                 840                 845             


Phe Arg Arg Trp Ala Ser Phe Arg Arg Glu Ala Glu Ala Ser Leu Asp 
    850                 855                 860                 


Asn Arg Asp Glu Leu Leu Met Glu Thr Ala Gln His Leu Glu Asn Gln 
865                 870                 875                 880 


Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp Arg Leu Gln Glu Gly 
                885                 890                 895     


Val Pro Asp Thr Ile Ala Thr Leu Arg Glu Ala Gly Ile Gln Leu Trp 
            900                 905                 910         


Val Leu Thr Gly Asp Lys Gln Glu Thr Ala Val Asn Ile Ala His Ser 
        915                 920                 925             


Cys Arg Leu Leu Asn Gln Thr Asp Thr Val Tyr Thr Ile Asn Thr Glu 
    930                 935                 940                 


Asn Gln Glu Thr Cys Glu Ser Ile Leu Asn Cys Ala Leu Glu Glu Leu 
945                 950                 955                 960 


Lys Gln Phe Arg Glu Leu Gln Lys Pro Asp Arg Lys Leu Phe Gly Phe 
                965                 970                 975     


Arg Leu Pro Ser Lys Thr Pro Ser Ile Thr Ser Glu Ala Val Val Pro 
            980                 985                 990         


Glu Ala Gly Leu Val Ile Asp Gly  Lys Thr Leu Asn Ala  Ile Phe Gln 
        995                 1000                 1005             


Gly Lys  Leu Glu Lys Lys Phe  Leu Glu Leu Thr Gln  Tyr Cys Arg 
    1010                 1015                 1020             


Ser Val  Leu Cys Cys Arg Ser  Thr Pro Leu Gln Lys  Ser Met Ile 
    1025                 1030                 1035             


Val Lys  Leu Val Arg Asp Lys  Leu Arg Val Met Thr  Leu Ser Ile 
    1040                 1045                 1050             


Gly Asp  Gly Ala Asn Asp Val  Ser Met Ile Gln Ala  Ala Asp Ile 
    1055                 1060                 1065             


Gly Ile  Gly Ile Ser Gly Gln  Glu Gly Met Gln Ala  Val Met Ser 
    1070                 1075                 1080             


Ser Asp  Phe Ala Ile Thr Arg  Phe Lys His Leu Lys  Lys Leu Leu 
    1085                 1090                 1095             


Leu Val  His Gly His Trp Cys  Tyr Ser Arg Leu Ala  Arg Met Val 
    1100                 1105                 1110             


Val Tyr  Tyr Leu Tyr Lys Asn  Val Cys Tyr Val Asn  Leu Leu Phe 
    1115                 1120                 1125             


Trp Tyr  Gln Phe Phe Cys Gly  Phe Ser Ser Ser Thr  Met Ile Asp 
    1130                 1135                 1140             


Tyr Trp  Gln Met Ile Phe Phe  Asn Leu Phe Phe Thr  Ser Leu Pro 
    1145                 1150                 1155             


Pro Leu  Val Phe Gly Val Leu  Asp Lys Asp Ile Ser  Ala Glu Thr 
    1160                 1165                 1170             


Leu Leu  Ala Leu Pro Glu Leu  Tyr Lys Ser Gly Gln  Asn Ser Glu 
    1175                 1180                 1185             


Cys Tyr  Asn Leu Ser Thr Phe  Trp Ile Ser Met Val  Asp Ala Phe 
    1190                 1195                 1200             


Tyr Gln  Ser Leu Ile Cys Phe  Phe Ile Pro Tyr Leu  Ala Tyr Lys 
    1205                 1210                 1215             


Gly Ser  Asp Ile Asp Val Phe  Thr Phe Gly Thr Pro  Ile Asn Thr 
    1220                 1225                 1230             


Ile Ser  Leu Thr Thr Ile Leu  Leu His Gln Ala Met  Glu Met Lys 
    1235                 1240                 1245             


Thr Trp  Thr Ile Phe His Gly  Val Val Leu Leu Gly  Ser Phe Leu 
    1250                 1255                 1260             


Met Tyr  Phe Leu Val Ser Leu  Leu Tyr Asn Ala Thr  Cys Val Ile 
    1265                 1270                 1275             


Cys Asn  Ser Pro Thr Asn Pro  Tyr Trp Val Met Glu  Gly Gln Leu 
    1280                 1285                 1290             


Ser Asn  Pro Thr Phe Tyr Leu  Val Cys Phe Leu Thr  Pro Val Val 
    1295                 1300                 1305             


Ala Leu  Leu Pro Arg Tyr Phe  Phe Leu Ser Leu Gln  Gly Thr Cys 
    1310                 1315                 1320             


Gly Lys  Ser Leu Ile Ser Lys  Ala Gln Lys Ile Asp  Lys Leu Pro 
    1325                 1330                 1335             


Pro Asp  Lys Arg Asn Leu Glu  Ile Gln Ser Trp Arg  Ser Arg Gln 
    1340                 1345                 1350             


Arg Pro  Ala Pro Val Pro Glu  Val Ala Arg Pro Thr  His His Pro 
    1355                 1360                 1365             


Val Ser  Ser Ile Thr Gly Gln  Asp Phe Ser Ala Ser  Thr Pro Lys 
    1370                 1375                 1380             


Ser Ser  Asn Pro Pro Lys Arg  Lys His Val Glu Glu  Ser Val Leu 
    1385                 1390                 1395             


His Glu  Gln Arg Cys Gly Thr  Glu Cys Met Arg Asp  Asp Ser Cys 
    1400                 1405                 1410             


Ser Gly  Asp Ser Ser Ala Gln  Leu Ser Ser Gly Glu  His Leu Leu 
    1415                 1420                 1425             


Gly Pro  Asn Arg Ile Met Ala  Tyr Ser Arg Gly Gln  Thr Asp Met 
    1430                 1435                 1440             


Cys Arg  Cys Ser Lys Arg Ser  Ser His Arg Arg Ser  Gln Ser Ser 
    1445                 1450                 1455             


Leu Thr  Ile 
    1460     


<210>  907
<211>  1426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP10D__Homo_sapiens__NP_065186

<400>  907

Met Thr Glu Ala Leu Gln Trp Ala Arg Tyr His Trp Arg Arg Leu Ile 
1               5                   10                  15      


Arg Gly Ala Thr Arg Asp Asp Asp Ser Gly Pro Tyr Asn Tyr Ser Ser 
            20                  25                  30          


Leu Leu Ala Cys Gly Arg Lys Ser Ser Gln Thr Pro Lys Leu Ser Gly 
        35                  40                  45              


Arg His Arg Ile Val Val Pro His Ile Gln Pro Phe Lys Asp Glu Tyr 
    50                  55                  60                  


Glu Lys Phe Ser Gly Ala Tyr Val Asn Asn Arg Ile Arg Thr Thr Lys 
65                  70                  75                  80  


Tyr Thr Leu Leu Asn Phe Val Pro Arg Asn Leu Phe Glu Gln Phe His 
                85                  90                  95      


Arg Ala Ala Asn Leu Tyr Phe Leu Phe Leu Val Val Leu Asn Trp Val 
            100                 105                 110         


Pro Leu Val Glu Ala Phe Gln Lys Glu Ile Thr Met Leu Pro Leu Val 
        115                 120                 125             


Val Val Leu Thr Ile Ile Ala Ile Lys Asp Gly Leu Glu Asp Tyr Arg 
    130                 135                 140                 


Lys Tyr Lys Ile Asp Lys Gln Ile Asn Asn Leu Ile Thr Lys Val Tyr 
145                 150                 155                 160 


Ser Arg Lys Glu Lys Lys Tyr Ile Asp Arg Cys Trp Lys Asp Val Thr 
                165                 170                 175     


Val Gly Asp Phe Ile Arg Leu Ser Cys Asn Glu Val Ile Pro Ala Asp 
            180                 185                 190         


Met Val Leu Leu Phe Ser Thr Asp Pro Asp Gly Ile Cys His Ile Glu 
        195                 200                 205             


Thr Ser Gly Leu Asp Gly Glu Ser Asn Leu Lys Gln Arg Gln Val Val 
    210                 215                 220                 


Arg Gly Tyr Ala Glu Gln Asp Ser Glu Val Asp Pro Glu Lys Phe Ser 
225                 230                 235                 240 


Ser Arg Ile Glu Cys Glu Ser Pro Asn Asn Asp Leu Ser Arg Phe Arg 
                245                 250                 255     


Gly Phe Leu Glu His Ser Asn Lys Glu Arg Val Gly Leu Ser Lys Glu 
            260                 265                 270         


Asn Leu Leu Leu Arg Gly Cys Thr Ile Arg Asn Thr Glu Ala Val Val 
        275                 280                 285             


Gly Ile Val Val Tyr Ala Gly His Glu Thr Lys Ala Met Leu Asn Asn 
    290                 295                 300                 


Ser Gly Pro Arg Tyr Lys Arg Ser Lys Leu Glu Arg Arg Ala Asn Thr 
305                 310                 315                 320 


Asp Val Leu Trp Cys Val Met Leu Leu Val Ile Met Cys Leu Thr Gly 
                325                 330                 335     


Ala Val Gly His Gly Ile Trp Leu Ser Arg Tyr Glu Lys Met His Phe 
            340                 345                 350         


Phe Asn Val Pro Glu Pro Asp Gly His Ile Ile Ser Pro Leu Leu Ala 
        355                 360                 365             


Gly Phe Tyr Met Phe Trp Thr Met Ile Ile Leu Leu Gln Val Leu Ile 
    370                 375                 380                 


Pro Ile Ser Leu Tyr Val Ser Ile Glu Ile Val Lys Leu Gly Gln Ile 
385                 390                 395                 400 


Tyr Phe Ile Gln Ser Asp Val Asp Phe Tyr Asn Glu Lys Met Asp Ser 
                405                 410                 415     


Ile Val Gln Cys Arg Ala Leu Asn Ile Ala Glu Asp Leu Gly Gln Ile 
            420                 425                 430         


Gln Tyr Leu Phe Ser Asp Lys Thr Gly Thr Leu Thr Glu Asn Lys Met 
        435                 440                 445             


Val Phe Arg Arg Cys Ser Val Ala Gly Phe Asp Tyr Cys His Glu Glu 
    450                 455                 460                 


Asn Ala Arg Arg Leu Glu Ser Tyr Gln Glu Ala Val Ser Glu Asp Glu 
465                 470                 475                 480 


Asp Phe Ile Asp Thr Val Ser Gly Ser Leu Ser Asn Met Ala Lys Pro 
                485                 490                 495     


Arg Ala Pro Ser Cys Arg Thr Val His Asn Gly Pro Leu Gly Asn Lys 
            500                 505                 510         


Pro Ser Asn His Leu Ala Gly Ser Ser Phe Thr Leu Gly Ser Gly Glu 
        515                 520                 525             


Gly Ala Ser Glu Val Pro His Ser Arg Gln Ala Ala Phe Ser Ser Pro 
    530                 535                 540                 


Ile Glu Thr Asp Val Val Pro Asp Thr Arg Leu Leu Asp Lys Phe Ser 
545                 550                 555                 560 


Gln Ile Thr Pro Arg Leu Phe Met Pro Leu Asp Glu Thr Ile Gln Asn 
                565                 570                 575     


Pro Pro Met Glu Thr Leu Tyr Ile Ile Asp Phe Phe Ile Ala Leu Ala 
            580                 585                 590         


Ile Cys Asn Thr Val Val Val Ser Ala Pro Asn Gln Pro Arg Gln Lys 
        595                 600                 605             


Ile Arg His Pro Ser Leu Gly Gly Leu Pro Ile Lys Ser Leu Glu Glu 
    610                 615                 620                 


Ile Lys Ser Leu Phe Gln Arg Trp Ser Val Arg Arg Ser Ser Ser Pro 
625                 630                 635                 640 


Ser Leu Asn Ser Gly Lys Glu Pro Ser Ser Gly Val Pro Asn Ala Phe 
                645                 650                 655     


Val Ser Arg Leu Pro Leu Phe Ser Arg Met Lys Pro Ala Ser Pro Val 
            660                 665                 670         


Glu Glu Glu Val Ser Gln Val Cys Glu Ser Pro Gln Cys Ser Ser Ser 
        675                 680                 685             


Ser Ala Cys Cys Thr Glu Thr Glu Lys Gln His Gly Asp Ala Gly Leu 
    690                 695                 700                 


Leu Asn Gly Lys Ala Glu Ser Leu Pro Gly Gln Pro Leu Ala Cys Asn 
705                 710                 715                 720 


Leu Cys Tyr Glu Ala Glu Ser Pro Asp Glu Ala Ala Leu Val Tyr Ala 
                725                 730                 735     


Ala Arg Ala Tyr Gln Cys Thr Leu Arg Ser Arg Thr Pro Glu Gln Val 
            740                 745                 750         


Met Val Asp Phe Ala Ala Leu Gly Pro Leu Thr Phe Gln Leu Leu His 
        755                 760                 765             


Ile Leu Pro Phe Asp Ser Val Arg Lys Arg Met Ser Val Val Val Arg 
    770                 775                 780                 


His Pro Leu Ser Asn Gln Val Val Val Tyr Thr Lys Gly Ala Asp Ser 
785                 790                 795                 800 


Val Ile Met Glu Leu Leu Ser Val Ala Ser Pro Asp Gly Ala Ser Leu 
                805                 810                 815     


Glu Lys Gln Gln Met Ile Val Arg Glu Lys Thr Gln Lys His Leu Asp 
            820                 825                 830         


Asp Tyr Ala Lys Gln Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val 
        835                 840                 845             


Met Ser Asp Thr Glu Tyr Ala Glu Trp Leu Arg Asn His Phe Leu Ala 
    850                 855                 860                 


Glu Thr Ser Ile Asp Asn Arg Glu Glu Leu Leu Leu Glu Ser Ala Met 
865                 870                 875                 880 


Arg Leu Glu Asn Lys Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp 
                885                 890                 895     


Arg Leu Gln Glu Gly Val Pro Glu Ser Ile Glu Ala Leu His Lys Ala 
            900                 905                 910         


Gly Ile Lys Ile Trp Met Leu Thr Gly Asp Lys Gln Glu Thr Ala Val 
        915                 920                 925             


Asn Ile Ala Tyr Ala Cys Lys Leu Leu Glu Pro Asp Asp Lys Leu Phe 
    930                 935                 940                 


Ile Leu Asn Thr Gln Ser Lys Asp Ala Cys Gly Met Leu Met Ser Thr 
945                 950                 955                 960 


Ile Leu Lys Glu Leu Gln Lys Lys Thr Gln Ala Leu Pro Glu Gln Val 
                965                 970                 975     


Ser Leu Ser Glu Asp Leu Leu Gln Pro Pro Val Pro Arg Asp Ser Gly 
            980                 985                 990         


Leu Arg Ala Gly Leu Ile Ile Thr  Gly Lys Thr Leu Glu  Phe Ala Leu 
        995                 1000                 1005             


Gln Glu  Ser Leu Gln Lys Gln  Phe Leu Glu Leu Thr  Ser Trp Cys 
    1010                 1015                 1020             


Gln Ala  Val Val Cys Cys Arg  Ala Thr Pro Leu Gln  Lys Ser Glu 
    1025                 1030                 1035             


Val Val  Lys Leu Val Arg Ser  His Leu Gln Val Met  Thr Leu Ala 
    1040                 1045                 1050             


Ile Gly  Asp Gly Ala Asn Asp  Val Ser Met Ile Gln  Val Ala Asp 
    1055                 1060                 1065             


Ile Gly  Ile Gly Val Ser Gly  Gln Glu Gly Met Gln  Ala Val Met 
    1070                 1075                 1080             


Ala Ser  Asp Phe Ala Val Ser  Gln Phe Lys His Leu  Ser Lys Leu 
    1085                 1090                 1095             


Leu Leu  Val His Gly His Trp  Cys Tyr Thr Arg Leu  Ser Asn Met 
    1100                 1105                 1110             


Ile Leu  Tyr Phe Phe Tyr Lys  Asn Val Ala Tyr Val  Asn Leu Leu 
    1115                 1120                 1125             


Phe Trp  Tyr Gln Phe Phe Cys  Gly Phe Ser Gly Thr  Ser Met Thr 
    1130                 1135                 1140             


Asp Tyr  Trp Val Leu Ile Phe  Phe Asn Leu Leu Phe  Thr Ser Ala 
    1145                 1150                 1155             


Pro Pro  Val Ile Tyr Gly Val  Leu Glu Lys Asp Val  Ser Ala Glu 
    1160                 1165                 1170             


Thr Leu  Met Gln Leu Pro Glu  Leu Tyr Arg Ser Gly  Gln Lys Ser 
    1175                 1180                 1185             


Glu Ala  Tyr Leu Pro His Thr  Phe Trp Ile Thr Leu  Leu Asp Ala 
    1190                 1195                 1200             


Phe Tyr  Gln Ser Leu Val Cys  Phe Phe Val Pro Tyr  Phe Thr Tyr 
    1205                 1210                 1215             


Gln Gly  Ser Asp Thr Asp Ile  Phe Ala Phe Gly Asn  Pro Leu Asn 
    1220                 1225                 1230             


Thr Ala  Ala Leu Phe Ile Val  Leu Leu His Leu Val  Ile Glu Ser 
    1235                 1240                 1245             


Lys Ser  Leu Thr Trp Ile His  Leu Leu Val Ile Ile  Gly Ser Ile 
    1250                 1255                 1260             


Leu Ser  Tyr Phe Leu Phe Ala  Ile Val Phe Gly Ala  Met Cys Val 
    1265                 1270                 1275             


Thr Cys  Asn Pro Pro Ser Asn  Pro Tyr Trp Ile Met  Gln Glu His 
    1280                 1285                 1290             


Met Leu  Asp Pro Val Phe Tyr  Leu Val Cys Ile Leu  Thr Thr Ser 
    1295                 1300                 1305             


Ile Ala  Leu Leu Pro Arg Phe  Val Tyr Arg Val Leu  Gln Gly Ser 
    1310                 1315                 1320             


Leu Phe  Pro Ser Pro Ile Leu  Arg Ala Lys His Phe  Asp Arg Leu 
    1325                 1330                 1335             


Thr Pro  Glu Glu Arg Thr Lys  Ala Leu Lys Lys Trp  Arg Gly Ala 
    1340                 1345                 1350             


Gly Lys  Met Asn Gln Val Thr  Ser Lys Tyr Ala Asn  Gln Ser Ala 
    1355                 1360                 1365             


Gly Lys  Ser Gly Arg Arg Pro  Met Pro Gly Pro Ser  Ala Val Phe 
    1370                 1375                 1380             


Ala Met  Lys Ser Ala Ser Ser  Cys Ala Ile Glu Gln  Gly Asn Leu 
    1385                 1390                 1395             


Ser Leu  Cys Glu Thr Ala Leu  Asp Gln Gly Tyr Ser  Glu Thr Lys 
    1400                 1405                 1410             


Ala Phe  Glu Met Ala Gly Pro  Ser Lys Gly Lys Glu  Ser 
    1415                 1420                 1425     


<210>  908
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP11A__Homo_sapiens__NP_056020

<400>  908

Met Asp Cys Ser Leu Val Arg Thr Leu Val His Arg Tyr Cys Ala Gly 
1               5                   10                  15      


Glu Glu Asn Trp Val Asp Ser Arg Thr Ile Tyr Val Gly His Arg Glu 
            20                  25                  30          


Pro Pro Pro Gly Ala Glu Ala Tyr Ile Pro Gln Arg Tyr Pro Asp Asn 
        35                  40                  45              


Arg Ile Val Ser Ser Lys Tyr Thr Phe Trp Asn Phe Ile Pro Lys Asn 
    50                  55                  60                  


Leu Phe Glu Gln Phe Arg Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile 
65                  70                  75                  80  


Phe Leu Val Gln Leu Ile Ile Asp Thr Pro Thr Ser Pro Val Thr Ser 
                85                  90                  95      


Gly Leu Pro Leu Phe Phe Val Ile Thr Val Thr Ala Ile Lys Gln Gly 
            100                 105                 110         


Tyr Glu Asp Trp Leu Arg His Lys Ala Asp Asn Ala Met Asn Gln Cys 
        115                 120                 125             


Pro Val His Phe Ile Gln His Gly Lys Leu Val Arg Lys Gln Ser Arg 
    130                 135                 140                 


Lys Leu Arg Val Gly Asp Ile Val Met Val Lys Glu Asp Glu Thr Phe 
145                 150                 155                 160 


Pro Cys Asp Leu Ile Phe Leu Ser Ser Asn Arg Gly Asp Gly Thr Cys 
                165                 170                 175     


His Val Thr Thr Ala Ser Leu Asp Gly Glu Ser Ser His Lys Thr His 
            180                 185                 190         


Tyr Ala Val Gln Asp Thr Lys Gly Phe His Thr Glu Glu Asp Ile Gly 
        195                 200                 205             


Gly Leu His Ala Thr Ile Glu Cys Glu Gln Pro Gln Pro Asp Leu Tyr 
    210                 215                 220                 


Lys Phe Val Gly Arg Ile Asn Val Tyr Ser Asp Leu Asn Asp Pro Val 
225                 230                 235                 240 


Val Arg Pro Leu Gly Ser Glu Asn Leu Leu Leu Arg Gly Ala Thr Leu 
                245                 250                 255     


Lys Asn Thr Glu Lys Ile Phe Gly Val Ala Ile Tyr Thr Gly Met Glu 
            260                 265                 270         


Thr Lys Met Ala Leu Asn Tyr Gln Ser Lys Ser Gln Lys Arg Ser Ala 
        275                 280                 285             


Val Glu Lys Ser Met Asn Ala Phe Leu Ile Val Tyr Leu Cys Ile Leu 
    290                 295                 300                 


Ile Ser Lys Ala Leu Ile Asn Thr Val Leu Lys Tyr Met Trp Gln Ser 
305                 310                 315                 320 


Glu Pro Phe Arg Asp Glu Pro Trp Tyr Asn Gln Lys Thr Glu Ser Glu 
                325                 330                 335     


Arg Gln Arg Asn Leu Phe Leu Lys Ala Phe Thr Asp Phe Leu Ala Phe 
            340                 345                 350         


Met Val Leu Phe Asn Tyr Ile Ile Pro Val Ser Met Tyr Val Thr Val 
        355                 360                 365             


Glu Met Gln Lys Phe Leu Gly Ser Tyr Phe Ile Thr Trp Asp Glu Asp 
    370                 375                 380                 


Met Phe Asp Glu Glu Thr Gly Glu Gly Pro Leu Val Asn Thr Ser Asp 
385                 390                 395                 400 


Leu Asn Glu Glu Leu Gly Gln Val Glu Tyr Ile Phe Thr Asp Lys Thr 
                405                 410                 415     


Gly Thr Leu Thr Glu Asn Asn Met Glu Phe Lys Glu Cys Cys Ile Glu 
            420                 425                 430         


Gly His Val Tyr Val Pro His Val Ile Cys Asn Gly Gln Val Leu Pro 
        435                 440                 445             


Glu Ser Ser Gly Ile Asp Met Ile Asp Ser Ser Pro Ser Val Asn Gly 
    450                 455                 460                 


Arg Glu Arg Glu Glu Leu Phe Phe Arg Ala Leu Cys Leu Cys His Thr 
465                 470                 475                 480 


Val Gln Val Lys Asp Asp Asp Ser Val Asp Gly Pro Arg Lys Ser Pro 
                485                 490                 495     


Asp Gly Gly Lys Ser Cys Val Tyr Ile Ser Ser Ser Pro Asp Glu Val 
            500                 505                 510         


Ala Leu Val Glu Gly Val Gln Arg Leu Gly Phe Thr Tyr Leu Arg Leu 
        515                 520                 525             


Lys Asp Asn Tyr Met Glu Ile Leu Asn Arg Glu Asn His Ile Glu Arg 
    530                 535                 540                 


Phe Glu Leu Leu Glu Ile Leu Ser Phe Asp Ser Val Arg Arg Arg Met 
545                 550                 555                 560 


Ser Val Ile Val Lys Ser Ala Thr Gly Glu Ile Tyr Leu Phe Cys Lys 
                565                 570                 575     


Gly Ala Asp Ser Ser Ile Phe Pro Arg Val Ile Glu Gly Lys Val Asp 
            580                 585                 590         


Gln Ile Arg Ala Arg Val Glu Arg Asn Ala Val Glu Gly Leu Arg Thr 
        595                 600                 605             


Leu Cys Val Ala Tyr Lys Arg Leu Ile Gln Glu Glu Tyr Glu Gly Ile 
    610                 615                 620                 


Cys Lys Leu Leu Gln Ala Ala Lys Val Ala Leu Gln Asp Arg Glu Lys 
625                 630                 635                 640 


Lys Leu Ala Glu Ala Tyr Glu Gln Ile Glu Lys Asp Leu Thr Leu Leu 
                645                 650                 655     


Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Glu Lys Ala Ala Asp Thr 
            660                 665                 670         


Ile Glu Ala Leu Gln Lys Ala Gly Ile Lys Val Trp Val Leu Thr Gly 
        675                 680                 685             


Asp Lys Met Glu Thr Ala Ala Ala Thr Cys Tyr Ala Cys Lys Leu Phe 
    690                 695                 700                 


Arg Arg Asn Thr Gln Leu Leu Glu Leu Thr Thr Lys Arg Ile Glu Glu 
705                 710                 715                 720 


Gln Ser Leu His Asp Val Leu Phe Glu Leu Ser Lys Thr Val Leu Arg 
                725                 730                 735     


His Ser Gly Ser Leu Thr Arg Asp Asn Leu Ser Gly Leu Ser Ala Asp 
            740                 745                 750         


Met Gln Asp Tyr Gly Leu Ile Ile Asp Gly Ala Ala Leu Ser Leu Ile 
        755                 760                 765             


Met Lys Pro Arg Glu Asp Gly Ser Ser Gly Asn Tyr Arg Glu Leu Phe 
    770                 775                 780                 


Leu Glu Ile Cys Arg Ser Cys Ser Ala Val Leu Cys Cys Arg Met Ala 
785                 790                 795                 800 


Pro Leu Gln Lys Ala Gln Ile Val Lys Leu Ile Lys Phe Ser Lys Glu 
                805                 810                 815     


His Pro Ile Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met 
            820                 825                 830         


Ile Leu Glu Ala His Val Gly Ile Gly Val Ile Gly Lys Glu Gly Arg 
        835                 840                 845             


Gln Ala Ala Arg Asn Ser Asp Tyr Ala Ile Pro Lys Phe Lys His Leu 
    850                 855                 860                 


Lys Lys Met Leu Leu Val His Gly His Phe Tyr Tyr Ile Arg Ile Ser 
865                 870                 875                 880 


Glu Leu Val Gln Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Phe Pro 
                885                 890                 895     


Gln Phe Leu Tyr Gln Phe Phe Cys Gly Phe Ser Gln Gln Thr Leu Tyr 
            900                 905                 910         


Asp Thr Ala Tyr Leu Thr Leu Tyr Asn Ile Ser Phe Thr Ser Leu Pro 
        915                 920                 925             


Ile Leu Leu Tyr Ser Leu Met Glu Gln His Val Gly Ile Asp Val Leu 
    930                 935                 940                 


Lys Arg Asp Pro Thr Leu Tyr Arg Asp Val Ala Lys Asn Ala Leu Leu 
945                 950                 955                 960 


Arg Trp Arg Val Phe Ile Tyr Trp Thr Leu Leu Gly Leu Phe Asp Ala 
                965                 970                 975     


Leu Val Phe Phe Phe Gly Ala Tyr Phe Val Phe Glu Asn Thr Thr Val 
            980                 985                 990         


Thr Ser Asn Gly Gln Ile Phe Gly  Asn Trp Thr Phe Gly  Thr Leu Val 
        995                 1000                 1005             


Phe Thr  Val Met Val Phe Thr  Val Thr Leu Lys Leu  Ala Leu Asp 
    1010                 1015                 1020             


Thr His  Tyr Trp Thr Trp Ile  Asn His Phe Val Ile  Trp Gly Ser 
    1025                 1030                 1035             


Leu Leu  Phe Tyr Val Val Phe  Ser Leu Leu Trp Gly  Gly Val Ile 
    1040                 1045                 1050             


Trp Pro  Phe Leu Asn Tyr Gln  Arg Met Tyr Tyr Val  Phe Ile Gln 
    1055                 1060                 1065             


Met Leu  Ser Ser Gly Pro Ala  Trp Leu Ala Ile Val  Leu Leu Val 
    1070                 1075                 1080             


Thr Ile  Ser Leu Leu Pro Asp  Val Leu Lys Lys Val  Leu Cys Arg 
    1085                 1090                 1095             


Gln Leu  Trp Pro Thr Ala Thr  Glu Arg Val Gln Thr  Lys Ser Gln 
    1100                 1105                 1110             


Cys Leu  Ser Val Glu Gln Ser  Thr Ile Phe Met Leu  Ser Gln Thr 
    1115                 1120                 1125             


Ser Ser  Ser Leu Ser Phe 
    1130                 


<210>  909
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP11AUN__Homo_sapiens__NP_997323

<400>  909

Met Asn Ser Pro Glu Ala Arg Leu Cys Val Ala Gln Cys Arg Asp Ser 
1               5                   10                  15      


Tyr Pro Gly Cys Gln Pro Leu Lys Asp Thr Arg Ala Trp Ala Ser Ser 
            20                  25                  30          


Leu Lys Met Asp Pro Ala Gly Leu Glu Gly Gly Pro Arg Asp Glu Ser 
        35                  40                  45              


Arg Asp Glu Pro Pro Ile Arg Ala Gln Ala Ala Ser Trp Asp Gln Pro 
    50                  55                  60                  


Gln Gly Cys Leu Thr Tyr Lys Gly Arg Arg Ser Ala Ser Gly Thr Gln 
65                  70                  75                  80  


Lys Gln Leu Gln Leu Pro Asp Thr Leu Ser Ser Leu Leu Cys Trp Arg 
                85                  90                  95      


Gly Ala Ile Met Val Tyr Ile Lys Val Thr Val Gln Thr Asp Asp Ser 
            100                 105                 110         


Asn Lys Leu Leu Ser Leu Leu Tyr Arg 
        115                 120     


<210>  910
<211>  1177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP11B__Homo_sapiens__NP_055431

<400>  910

Met Trp Arg Trp Ile Arg Gln Gln Leu Gly Phe Asp Pro Pro His Gln 
1               5                   10                  15      


Ser Asp Thr Arg Thr Ile Tyr Val Ala Asn Arg Phe Pro Gln Asn Gly 
            20                  25                  30          


Leu Tyr Thr Pro Gln Lys Phe Ile Asp Asn Arg Ile Ile Ser Ser Lys 
        35                  40                  45              


Tyr Thr Val Trp Asn Phe Val Pro Lys Asn Leu Phe Glu Gln Phe Arg 
    50                  55                  60                  


Arg Val Ala Asn Phe Tyr Phe Leu Ile Ile Phe Leu Val Gln Leu Met 
65                  70                  75                  80  


Ile Asp Thr Pro Thr Ser Pro Val Thr Ser Gly Leu Pro Leu Phe Phe 
                85                  90                  95      


Val Ile Thr Val Thr Ala Ile Lys Gln Gly Tyr Glu Asp Trp Leu Arg 
            100                 105                 110         


His Asn Ser Asp Asn Glu Val Asn Gly Ala Pro Val Tyr Val Val Arg 
        115                 120                 125             


Ser Gly Gly Leu Val Lys Thr Arg Ser Lys Asn Ile Arg Val Gly Asp 
    130                 135                 140                 


Ile Val Arg Ile Ala Lys Asp Glu Ile Phe Pro Ala Asp Leu Val Leu 
145                 150                 155                 160 


Leu Ser Ser Asp Arg Leu Asp Gly Ser Cys His Val Thr Thr Ala Ser 
                165                 170                 175     


Leu Asp Gly Glu Thr Asn Leu Lys Thr His Val Ala Val Pro Glu Thr 
            180                 185                 190         


Ala Leu Leu Gln Thr Val Ala Asn Leu Asp Thr Leu Val Ala Val Ile 
        195                 200                 205             


Glu Cys Gln Gln Pro Glu Ala Asp Leu Tyr Arg Phe Met Gly Arg Met 
    210                 215                 220                 


Ile Ile Thr Gln Gln Met Glu Glu Ile Val Arg Pro Leu Gly Pro Glu 
225                 230                 235                 240 


Ser Leu Leu Leu Arg Gly Ala Arg Leu Lys Asn Thr Lys Glu Ile Phe 
                245                 250                 255     


Gly Val Ala Val Tyr Thr Gly Met Glu Thr Lys Met Ala Leu Asn Tyr 
            260                 265                 270         


Lys Ser Lys Ser Gln Lys Arg Ser Ala Val Glu Lys Ser Met Asn Thr 
        275                 280                 285             


Phe Leu Ile Ile Tyr Leu Val Ile Leu Ile Ser Glu Ala Val Ile Ser 
    290                 295                 300                 


Thr Ile Leu Lys Tyr Thr Trp Gln Ala Glu Glu Lys Trp Asp Glu Pro 
305                 310                 315                 320 


Trp Tyr Asn Gln Lys Thr Glu His Gln Arg Asn Ser Ser Lys Ile Leu 
                325                 330                 335     


Arg Phe Ile Ser Asp Phe Leu Ala Phe Leu Val Leu Tyr Asn Phe Ile 
            340                 345                 350         


Ile Pro Ile Ser Leu Tyr Val Thr Val Glu Met Gln Lys Phe Leu Gly 
        355                 360                 365             


Ser Phe Phe Ile Gly Trp Asp Leu Asp Leu Tyr His Glu Glu Ser Asp 
    370                 375                 380                 


Gln Lys Ala Gln Val Asn Thr Ser Asp Leu Asn Glu Glu Leu Gly Gln 
385                 390                 395                 400 


Val Glu Tyr Val Phe Thr Asp Lys Thr Gly Thr Leu Thr Glu Asn Glu 
                405                 410                 415     


Met Gln Phe Arg Glu Cys Ser Ile Asn Gly Met Lys Tyr Gln Glu Ile 
            420                 425                 430         


Asn Gly Arg Leu Val Pro Glu Gly Pro Thr Pro Asp Ser Ser Glu Gly 
        435                 440                 445             


Asn Leu Ser Tyr Leu Ser Ser Leu Ser His Leu Asn Asn Leu Ser His 
    450                 455                 460                 


Leu Thr Thr Ser Ser Ser Phe Arg Thr Ser Pro Glu Asn Glu Thr Glu 
465                 470                 475                 480 


Leu Ile Lys Glu His Asp Leu Phe Phe Lys Ala Val Ser Leu Cys His 
                485                 490                 495     


Thr Val Gln Ile Ser Asn Val Gln Thr Asp Cys Thr Gly Asp Gly Pro 
            500                 505                 510         


Trp Gln Ser Asn Leu Ala Pro Ser Gln Leu Glu Tyr Tyr Ala Ser Ser 
        515                 520                 525             


Pro Asp Glu Lys Ala Leu Val Glu Ala Ala Ala Arg Ile Gly Ile Val 
    530                 535                 540                 


Phe Ile Gly Asn Ser Glu Glu Thr Met Glu Val Lys Thr Leu Gly Lys 
545                 550                 555                 560 


Leu Glu Arg Tyr Lys Leu Leu His Ile Leu Glu Phe Asp Ser Asp Arg 
                565                 570                 575     


Arg Arg Met Ser Val Ile Val Gln Ala Pro Ser Gly Glu Lys Leu Leu 
            580                 585                 590         


Phe Ala Lys Gly Ala Glu Ser Ser Ile Leu Pro Lys Cys Ile Gly Gly 
        595                 600                 605             


Glu Ile Glu Lys Thr Arg Ile His Val Asp Glu Phe Ala Leu Lys Gly 
    610                 615                 620                 


Leu Arg Thr Leu Cys Ile Ala Tyr Arg Lys Phe Thr Ser Lys Glu Tyr 
625                 630                 635                 640 


Glu Glu Ile Asp Lys Arg Ile Phe Glu Ala Arg Thr Ala Leu Gln Gln 
                645                 650                 655     


Arg Glu Glu Lys Leu Ala Ala Val Phe Gln Phe Ile Glu Lys Asp Leu 
            660                 665                 670         


Ile Leu Leu Gly Ala Thr Ala Val Glu Asp Arg Leu Gln Asp Lys Val 
        675                 680                 685             


Arg Glu Thr Ile Glu Ala Leu Arg Met Ala Gly Ile Lys Val Trp Val 
    690                 695                 700                 


Leu Thr Gly Asp Lys His Glu Thr Ala Val Ser Val Ser Leu Ser Cys 
705                 710                 715                 720 


Gly His Phe His Arg Thr Met Asn Ile Leu Glu Leu Ile Asn Gln Lys 
                725                 730                 735     


Ser Asp Ser Glu Cys Ala Glu Gln Leu Arg Gln Leu Ala Arg Arg Ile 
            740                 745                 750         


Thr Glu Asp His Val Ile Gln His Gly Leu Val Val Asp Gly Thr Ser 
        755                 760                 765             


Leu Ser Leu Ala Leu Arg Glu His Glu Lys Leu Phe Met Glu Val Cys 
    770                 775                 780                 


Arg Asn Cys Ser Ala Val Leu Cys Cys Arg Met Ala Pro Leu Gln Lys 
785                 790                 795                 800 


Ala Lys Val Ile Arg Leu Ile Lys Ile Ser Pro Glu Lys Pro Ile Thr 
                805                 810                 815     


Leu Ala Val Gly Asp Gly Ala Asn Asp Val Ser Met Ile Gln Glu Ala 
            820                 825                 830         


His Val Gly Ile Gly Ile Met Gly Lys Glu Gly Arg Gln Ala Ala Arg 
        835                 840                 845             


Asn Ser Asp Tyr Ala Ile Ala Arg Phe Lys Phe Leu Ser Lys Leu Leu 
    850                 855                 860                 


Phe Val His Gly His Phe Tyr Tyr Ile Arg Ile Ala Thr Leu Val Gln 
865                 870                 875                 880 


Tyr Phe Phe Tyr Lys Asn Val Cys Phe Ile Thr Pro Gln Phe Leu Tyr 
                885                 890                 895     


Gln Phe Tyr Cys Leu Phe Ser Gln Gln Thr Leu Tyr Asp Ser Val Tyr 
            900                 905                 910         


Leu Thr Leu Tyr Asn Ile Cys Phe Thr Ser Leu Pro Ile Leu Ile Tyr 
        915                 920                 925             


Ser Leu Leu Glu Gln His Val Asp Pro His Val Leu Gln Asn Lys Pro 
    930                 935                 940                 


Thr Leu Tyr Arg Asp Ile Ser Lys Asn Arg Leu Leu Ser Ile Lys Thr 
945                 950                 955                 960 


Phe Leu Tyr Trp Thr Ile Leu Gly Phe Ser His Ala Phe Ile Phe Phe 
                965                 970                 975     


Phe Gly Ser Tyr Leu Leu Ile Gly Lys Asp Thr Ser Leu Leu Gly Asn 
            980                 985                 990         


Gly Gln Met Phe Gly Asn Trp Thr  Phe Gly Thr Leu Val  Phe Thr Val 
        995                 1000                 1005             


Met Val  Ile Thr Val Thr Val  Lys Met Ala Leu Glu  Thr His Phe 
    1010                 1015                 1020             


Trp Thr  Trp Ile Asn His Leu  Val Thr Trp Gly Ser  Ile Ile Phe 
    1025                 1030                 1035             


Tyr Phe  Val Phe Ser Leu Phe  Tyr Gly Gly Ile Leu  Trp Pro Phe 
    1040                 1045                 1050             


Leu Gly  Ser Gln Asn Met Tyr  Phe Val Phe Ile Gln  Leu Leu Ser 
    1055                 1060                 1065             


Ser Gly  Ser Ala Trp Phe Ala  Ile Ile Leu Met Val  Val Thr Cys 
    1070                 1075                 1080             


Leu Phe  Leu Asp Ile Ile Lys  Lys Val Phe Asp Arg  His Leu His 
    1085                 1090                 1095             


Pro Thr  Ser Thr Glu Lys Ala  Gln Leu Thr Glu Thr  Asn Ala Gly 
    1100                 1105                 1110             


Ile Lys  Cys Leu Asp Ser Met  Cys Cys Phe Pro Glu  Gly Glu Ala 
    1115                 1120                 1125             


Ala Cys  Ala Ser Val Gly Arg  Met Leu Glu Arg Val  Ile Gly Arg 
    1130                 1135                 1140             


Cys Ser  Pro Thr His Ile Ser  Arg Ser Trp Ser Ala  Ser Asp Pro 
    1145                 1150                 1155             


Phe Tyr  Thr Asn Asp Arg Ser  Ile Leu Thr Leu Ser  Thr Met Asp 
    1160                 1165                 1170             


Ser Ser  Thr Cys 
    1175         


<210>  911
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP12A__Homo_sapiens__NP_001172014

<400>  911

Met His Gln Lys Thr Pro Glu Ile Tyr Ser Val Glu Leu Ser Gly Thr 
1               5                   10                  15      


Lys Asp Ile Val Lys Thr Asp Lys Gly Asp Gly Lys Glu Lys Tyr Arg 
            20                  25                  30          


Gly Leu Lys Asn Asn Cys Leu Glu Leu Lys Lys Lys Asn His Lys Glu 
        35                  40                  45              


Glu Phe Gln Lys Glu Leu His Leu Asp Asp His Lys Leu Ser Asn Arg 
    50                  55                  60                  


Glu Leu Glu Glu Lys Tyr Gly Thr Asp Ile Ile Met Gly Leu Ser Ser 
65                  70                  75                  80  


Thr Arg Ala Ala Glu Leu Leu Ala Arg Asp Gly Pro Asn Ser Leu Thr 
                85                  90                  95      


Pro Pro Lys Gln Thr Pro Glu Ile Val Lys Phe Leu Lys Gln Met Val 
            100                 105                 110         


Gly Gly Phe Ser Ile Leu Leu Trp Val Gly Ala Phe Leu Cys Trp Ile 
        115                 120                 125             


Ala Tyr Gly Ile Gln Tyr Ser Ser Asp Lys Ser Ala Ser Leu Asn Asn 
    130                 135                 140                 


Val Tyr Leu Gly Cys Val Leu Gly Leu Val Val Ile Leu Thr Gly Ile 
145                 150                 155                 160 


Phe Ala Tyr Tyr Gln Glu Ala Lys Ser Thr Asn Ile Met Ser Ser Phe 
                165                 170                 175     


Asn Lys Met Ile Pro Gln Gln Ala Leu Val Ile Arg Asp Ser Glu Lys 
            180                 185                 190         


Lys Thr Ile Pro Ser Glu Gln Leu Val Val Gly Asp Ile Val Glu Val 
        195                 200                 205             


Lys Gly Gly Asp Gln Ile Pro Ala Asp Ile Arg Val Leu Ser Ser Gln 
    210                 215                 220                 


Gly Cys Arg Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln 
225                 230                 235                 240 


Pro Arg Ser Ser Glu Phe Thr His Glu Asn Pro Leu Glu Thr Lys Asn 
                245                 250                 255     


Ile Cys Phe Tyr Ser Thr Thr Cys Leu Glu Ala Ser Thr Ser Pro Val 
            260                 265                 270         


Gly Thr Val Thr Gly Met Val Ile Asn Thr Gly Asp Arg Thr Ile Ile 
        275                 280                 285             


Gly His Ile Ala Ser Leu Ala Ser Gly Val Gly Asn Glu Lys Thr Pro 
    290                 295                 300                 


Ile Ala Ile Glu Ile Glu His Phe Val His Ile Val Ala Gly Val Ala 
305                 310                 315                 320 


Val Ser Ile Gly Ile Leu Phe Phe Ile Ile Ala Val Ser Leu Lys Tyr 
                325                 330                 335     


Gln Val Leu Asp Ser Ile Ile Phe Leu Ile Gly Ile Ile Val Ala Asn 
            340                 345                 350         


Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Thr Leu Ser Leu Thr 
        355                 360                 365             


Ala Lys Arg Met Ala Lys Lys Asn Cys Leu Val Lys Asn Leu Glu Ala 
    370                 375                 380                 


Val Glu Thr Leu Gly Ser Thr Ser Ile Ile Cys Ser Asp Lys Thr Gly 
385                 390                 395                 400 


Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Leu Trp Phe Asp Asn 
                405                 410                 415     


Gln Ile Phe Val Ala Asp Thr Ser Glu Asp His Ser Asn Gln Val Phe 
            420                 425                 430         


Asp Gln Ser Ser Arg Thr Trp Ala Ser Leu Ser Lys Ile Ile Thr Leu 
        435                 440                 445             


Cys Asn Arg Ala Glu Phe Lys Pro Gly Gln Glu Asn Val Pro Ile Met 
    450                 455                 460                 


Lys Lys Ala Val Ile Gly Asp Ala Ser Glu Thr Ala Leu Leu Lys Phe 
465                 470                 475                 480 


Ser Glu Val Ile Leu Gly Asp Val Met Glu Ile Arg Lys Arg Asn Arg 
                485                 490                 495     


Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Phe Gln Leu Ser 
            500                 505                 510         


Ile His Glu Met Asp Asp Pro His Gly Lys Arg Phe Leu Met Val Met 
        515                 520                 525             


Lys Gly Ala Pro Glu Arg Ile Leu Glu Lys Cys Ser Thr Ile Met Ile 
    530                 535                 540                 


Asn Gly Glu Glu His Pro Leu Asp Lys Ser Thr Ala Lys Thr Phe His 
545                 550                 555                 560 


Thr Ala Tyr Met Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe 
                565                 570                 575     


Cys His Leu Tyr Leu Pro Ala Asp Glu Phe Pro Glu Thr Tyr Ser Phe 
            580                 585                 590         


Asp Ile Asp Ala Met Asn Phe Pro Thr Ser Asn Leu Cys Phe Val Gly 
        595                 600                 605             


Leu Leu Ser Met Ile Asp Pro Pro Arg Ser Thr Val Pro Asp Ala Val 
    610                 615                 620                 


Thr Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp 
625                 630                 635                 640 


His Pro Ile Thr Ala Lys Ala Ile Ala Lys Ser Val Gly Ile Ile Ser 
                645                 650                 655     


Ala Asn Ser Glu Thr Val Glu Asp Ile Ala His Arg Leu Asn Ile Ala 
            660                 665                 670         


Val Glu Gln Val Asn Lys Arg Asp Ala Lys Ala Ala Val Val Thr Gly 
        675                 680                 685             


Met Glu Leu Lys Asp Met Ser Ser Glu Gln Leu Asp Glu Ile Leu Ala 
    690                 695                 700                 


Asn Tyr Gln Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu 
705                 710                 715                 720 


Ile Ile Val Glu Gly Cys Gln Arg Gln Asp Ala Val Val Ala Val Thr 
                725                 730                 735     


Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly 
            740                 745                 750         


Ile Ala Met Gly Ile Ala Gly Ser Asp Ala Ala Lys Asn Ala Ala Asp 
        755                 760                 765             


Met Val Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu 
    770                 775                 780                 


Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Thr Ile Ala Tyr Ser 
785                 790                 795                 800 


Leu Thr Lys Asn Ile Ala Glu Leu Cys Pro Phe Leu Ile Tyr Ile Ile 
                805                 810                 815     


Val Gly Leu Pro Leu Pro Ile Gly Thr Ile Thr Ile Leu Phe Ile Asp 
            820                 825                 830         


Leu Gly Thr Asp Ile Ile Pro Ser Ile Ala Leu Ala Tyr Glu Lys Ala 
        835                 840                 845             


Glu Ser Asp Ile Met Asn Arg Lys Pro Arg His Lys Asn Lys Asp Arg 
    850                 855                 860                 


Leu Val Asn Gln Pro Leu Ala Val Tyr Ser Tyr Leu His Ile Gly Leu 
865                 870                 875                 880 


Met Gln Ala Leu Gly Ala Phe Leu Val Tyr Phe Thr Val Tyr Ala Gln 
                885                 890                 895     


Glu Gly Phe Leu Pro Arg Thr Leu Ile Asn Leu Arg Val Glu Trp Glu 
            900                 905                 910         


Lys Asp Tyr Val Asn Asp Leu Lys Asp Ser Tyr Gly Gln Glu Trp Thr 
        915                 920                 925             


Arg Tyr Gln Arg Glu Tyr Leu Glu Trp Thr Gly Tyr Thr Ala Phe Phe 
    930                 935                 940                 


Val Gly Ile Leu Val Gln Gln Ile Ala Asp Leu Ile Ile Arg Lys Thr 
945                 950                 955                 960 


Arg Arg Asn Ser Ile Phe Gln Gln Gly Leu Phe Arg Asn Lys Val Ile 
                965                 970                 975     


Trp Val Gly Ile Thr Ser Gln Ile Ile Ile Gly Leu Ile Leu Ser Tyr 
            980                 985                 990         


Gly Leu Gly Ser Val Thr Ala Leu  Ser Phe Thr Met Leu  Arg Ala Gln 
        995                 1000                 1005             


Tyr Trp  Phe Val Ala Val Pro  His Ala Ile Leu Ile  Trp Val Tyr 
    1010                 1015                 1020             


Asp Glu  Val Arg Lys Leu Phe  Ile Arg Leu Tyr Pro  Gly Ser Trp 
    1025                 1030                 1035             


Trp Asp  Lys Asn Met Tyr Tyr  
    1040                 1045 


<210>  912
<211>  1226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP13A3__Homo_sapiens__NP_078800

<400>  912

Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu 
1               5                   10                  15      


Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val 
            20                  25                  30          


Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu Tyr 
        35                  40                  45              


Trp Met Pro Glu Trp Arg Val Lys Ala Thr Cys Val Arg Ala Ala Ile 
    50                  55                  60                  


Lys Asp Cys Glu Val Val Leu Leu Arg Thr Thr Asp Glu Phe Lys Met 
65                  70                  75                  80  


Trp Phe Cys Ala Lys Ile Arg Val Leu Ser Leu Glu Thr Tyr Pro Val 
                85                  90                  95      


Ser Ser Pro Lys Ser Met Ser Asn Lys Leu Ser Asn Gly His Ala Val 
            100                 105                 110         


Cys Leu Ile Glu Asn Pro Thr Glu Glu Asn Arg His Arg Ile Ser Lys 
        115                 120                 125             


Tyr Ser Gln Thr Glu Ser Gln Gln Ile Arg Tyr Phe Thr His His Ser 
    130                 135                 140                 


Val Lys Tyr Phe Trp Asn Asp Thr Ile His Asn Phe Asp Phe Leu Lys 
145                 150                 155                 160 


Gly Leu Asp Glu Gly Val Ser Cys Thr Ser Ile Tyr Glu Lys His Ser 
                165                 170                 175     


Ala Gly Leu Thr Lys Gly Met His Ala Tyr Arg Lys Leu Leu Tyr Gly 
            180                 185                 190         


Val Asn Glu Ile Ala Val Lys Val Pro Ser Val Phe Lys Leu Leu Ile 
        195                 200                 205             


Lys Glu Val Leu Asn Pro Phe Tyr Ile Phe Gln Leu Phe Ser Val Ile 
    210                 215                 220                 


Leu Trp Ser Thr Asp Glu Tyr Tyr Tyr Tyr Ala Leu Ala Ile Val Val 
225                 230                 235                 240 


Met Ser Ile Val Ser Ile Val Ser Ser Leu Tyr Ser Ile Arg Lys Gln 
                245                 250                 255     


Tyr Val Met Leu His Asp Met Val Ala Thr His Ser Thr Val Arg Val 
            260                 265                 270         


Ser Val Cys Arg Val Asn Glu Glu Ile Glu Glu Ile Phe Ser Thr Asp 
        275                 280                 285             


Leu Val Pro Gly Asp Val Met Val Ile Pro Leu Asn Gly Thr Ile Met 
    290                 295                 300                 


Pro Cys Asp Ala Val Leu Ile Asn Gly Thr Cys Ile Val Asn Glu Ser 
305                 310                 315                 320 


Met Leu Thr Gly Glu Ser Val Pro Val Thr Lys Thr Asn Leu Pro Asn 
                325                 330                 335     


Pro Ser Val Asp Val Lys Gly Ile Gly Asp Glu Leu Tyr Asn Pro Glu 
            340                 345                 350         


Thr His Lys Arg His Thr Leu Phe Cys Gly Thr Thr Val Ile Gln Thr 
        355                 360                 365             


Arg Phe Tyr Thr Gly Glu Leu Val Lys Ala Ile Val Val Arg Thr Gly 
    370                 375                 380                 


Phe Ser Thr Ser Lys Gly Gln Leu Val Arg Ser Ile Leu Tyr Pro Lys 
385                 390                 395                 400 


Pro Thr Asp Phe Lys Leu Tyr Arg Asp Ala Tyr Leu Phe Leu Leu Cys 
                405                 410                 415     


Leu Val Ala Val Ala Gly Ile Gly Phe Ile Tyr Thr Ile Ile Asn Ser 
            420                 425                 430         


Ile Leu Asn Glu Val Gln Val Gly Val Ile Ile Ile Glu Ser Leu Asp 
        435                 440                 445             


Ile Ile Thr Ile Thr Val Pro Pro Ala Leu Pro Ala Ala Met Thr Ala 
    450                 455                 460                 


Gly Ile Val Tyr Ala Gln Arg Arg Leu Lys Lys Ile Gly Ile Phe Cys 
465                 470                 475                 480 


Ile Ser Pro Gln Arg Ile Asn Ile Cys Gly Gln Leu Asn Leu Val Cys 
                485                 490                 495     


Phe Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Leu Trp Gly 
            500                 505                 510         


Ile Gln Arg Val Glu Asn Ala Arg Phe Leu Ser Pro Glu Glu Asn Val 
        515                 520                 525             


Cys Asn Glu Met Leu Val Lys Ser Gln Phe Val Ala Cys Met Ala Thr 
    530                 535                 540                 


Cys His Ser Leu Thr Lys Ile Glu Gly Val Leu Ser Gly Asp Pro Leu 
545                 550                 555                 560 


Asp Leu Lys Met Phe Glu Ala Ile Gly Trp Ile Leu Glu Glu Ala Thr 
                565                 570                 575     


Glu Glu Glu Thr Ala Leu His Asn Arg Ile Met Pro Thr Val Val Arg 
            580                 585                 590         


Pro Pro Lys Gln Leu Leu Pro Glu Ser Thr Pro Ala Gly Asn Gln Glu 
        595                 600                 605             


Met Glu Leu Phe Glu Leu Pro Ala Thr Tyr Glu Ile Gly Ile Val Arg 
    610                 615                 620                 


Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val Ala Arg 
625                 630                 635                 640 


Val Leu Gly Asp Arg Lys Met Asp Ala Tyr Met Lys Gly Ala Pro Glu 
                645                 650                 655     


Ala Ile Ala Gly Leu Cys Lys Pro Glu Thr Val Pro Val Asp Phe Gln 
            660                 665                 670         


Asn Val Leu Glu Asp Phe Thr Lys Gln Gly Phe Arg Val Ile Ala Leu 
        675                 680                 685             


Ala His Arg Lys Leu Glu Ser Lys Leu Thr Trp His Lys Val Gln Asn 
    690                 695                 700                 


Ile Ser Arg Asp Ala Ile Glu Asn Asn Met Asp Phe Met Gly Leu Ile 
705                 710                 715                 720 


Ile Met Gln Asn Lys Leu Lys Gln Glu Thr Pro Ala Val Leu Glu Asp 
                725                 730                 735     


Leu His Lys Ala Asn Ile Arg Thr Val Met Val Thr Gly Asp Ser Met 
            740                 745                 750         


Leu Thr Ala Val Ser Val Ala Arg Asp Cys Gly Met Ile Leu Pro Gln 
        755                 760                 765             


Asp Lys Val Ile Ile Ala Glu Ala Leu Pro Pro Lys Asp Gly Lys Val 
    770                 775                 780                 


Ala Lys Ile Asn Trp His Tyr Ala Asp Ser Leu Thr Gln Cys Ser His 
785                 790                 795                 800 


Pro Ser Ala Ile Asp Pro Glu Ala Ile Pro Val Lys Leu Val His Asp 
                805                 810                 815     


Ser Leu Glu Asp Leu Gln Met Thr Arg Tyr His Phe Ala Met Asn Gly 
            820                 825                 830         


Lys Ser Phe Ser Val Ile Leu Glu His Phe Gln Asp Leu Val Pro Lys 
        835                 840                 845             


Leu Met Leu His Gly Thr Val Phe Ala Arg Met Ala Pro Asp Gln Lys 
    850                 855                 860                 


Thr Gln Leu Ile Glu Ala Leu Gln Asn Val Asp Tyr Phe Val Gly Met 
865                 870                 875                 880 


Cys Gly Asp Gly Ala Asn Asp Cys Gly Ala Leu Lys Arg Ala His Gly 
                885                 890                 895     


Gly Ile Ser Leu Ser Glu Leu Glu Ala Ser Val Ala Ser Pro Phe Thr 
            900                 905                 910         


Ser Lys Thr Pro Ser Ile Ser Cys Val Pro Asn Leu Ile Arg Glu Gly 
        915                 920                 925             


Arg Ala Ala Leu Ile Thr Ser Phe Cys Val Phe Lys Phe Met Ala Leu 
    930                 935                 940                 


Tyr Ser Ile Ile Gln Tyr Phe Ser Val Thr Leu Leu Tyr Ser Ile Leu 
945                 950                 955                 960 


Ser Asn Leu Gly Asp Phe Gln Phe Leu Phe Ile Asp Leu Ala Ile Ile 
                965                 970                 975     


Leu Val Val Val Phe Thr Met Ser Leu Asn Pro Ala Trp Lys Glu Leu 
            980                 985                 990         


Val Ala Gln Arg Pro Pro Ser Gly  Leu Ile Ser Gly Ala  Leu Leu Phe 
        995                 1000                 1005             


Ser Val  Leu Ser Gln Ile Ile  Ile Cys Ile Gly Phe  Gln Ser Leu 
    1010                 1015                 1020             


Gly Phe  Phe Trp Val Lys Gln  Gln Pro Trp Tyr Glu  Val Trp His 
    1025                 1030                 1035             


Pro Lys  Ser Asp Ala Cys Asn  Thr Thr Gly Ser Gly  Phe Trp Asn 
    1040                 1045                 1050             


Ser Ser  His Val Asp Asn Glu  Thr Glu Leu Asp Glu  His Asn Ile 
    1055                 1060                 1065             


Gln Asn  Tyr Glu Asn Thr Thr  Val Phe Phe Ile Ser  Ser Phe Gln 
    1070                 1075                 1080             


Tyr Leu  Ile Val Ala Ile Ala  Phe Ser Lys Gly Lys  Pro Phe Arg 
    1085                 1090                 1095             


Gln Pro  Cys Tyr Lys Asn Tyr  Phe Phe Val Phe Ser  Val Ile Phe 
    1100                 1105                 1110             


Leu Tyr  Ile Phe Ile Leu Phe  Ile Met Leu Tyr Pro  Val Ala Ser 
    1115                 1120                 1125             


Val Asp  Gln Val Leu Gln Ile  Val Cys Val Pro Tyr  Gln Trp Arg 
    1130                 1135                 1140             


Val Thr  Met Leu Ile Ile Val  Leu Val Asn Ala Phe  Val Ser Ile 
    1145                 1150                 1155             


Thr Val  Glu Glu Ser Val Asp  Arg Trp Gly Lys Cys  Cys Leu Pro 
    1160                 1165                 1170             


Trp Ala  Leu Gly Cys Arg Lys  Lys Thr Pro Lys Ala  Lys Tyr Met 
    1175                 1180                 1185             


Tyr Leu  Ala Gln Glu Leu Leu  Val Asp Pro Glu Trp  Pro Pro Lys 
    1190                 1195                 1200             


Pro Gln  Thr Thr Thr Glu Ala  Lys Ala Leu Val Lys  Glu Asn Gly 
    1205                 1210                 1215             


Ser Cys  Gln Ile Ile Thr Ile  Thr 
    1220                 1225     


<210>  913
<211>  1196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP13A4__Homo_sapiens__NP_115655

<400>  913

Met Gly His Phe Glu Lys Gly Gln His Ala Leu Leu Asn Glu Gly Glu 
1               5                   10                  15      


Glu Asn Glu Met Glu Ile Phe Gly Tyr Arg Thr Gln Gly Cys Arg Lys 
            20                  25                  30          


Ser Leu Cys Leu Ala Gly Ser Ile Phe Ser Phe Gly Ile Leu Pro Leu 
        35                  40                  45              


Val Phe Tyr Trp Arg Pro Ala Trp His Val Trp Ala His Cys Val Pro 
    50                  55                  60                  


Cys Ser Leu Gln Glu Ala Asp Thr Val Leu Leu Arg Thr Thr Asp Glu 
65                  70                  75                  80  


Phe Gln Ile Tyr Ser Trp Lys Lys Val Ile Trp Ile Tyr Leu Ser Ala 
                85                  90                  95      


Leu Asn Ser Ala Phe Gly Leu Thr Pro Asp His Pro Leu Met Thr Asp 
            100                 105                 110         


Glu Glu Tyr Ile Ile Asn Arg Ala Ile Arg Lys Pro Asp Leu Lys Val 
        115                 120                 125             


Arg Cys Ile Lys Val Gln Lys Ile Arg Tyr Val Trp Asn Tyr Leu Glu 
    130                 135                 140                 


Gly Gln Phe Gln Lys Ile Gly Ser Leu Glu Asp Trp Leu Ser Ser Ala 
145                 150                 155                 160 


Lys Ile His Gln Lys Phe Gly Ser Gly Leu Thr Arg Glu Glu Gln Glu 
                165                 170                 175     


Ile Arg Arg Leu Ile Cys Gly Pro Asn Thr Ile Asp Val Glu Val Thr 
            180                 185                 190         


Pro Ile Trp Lys Leu Leu Ile Lys Glu Val Leu Asn Pro Phe Tyr Ile 
        195                 200                 205             


Phe Gln Leu Phe Ser Val Cys Leu Trp Phe Ser Glu Asp Tyr Lys Glu 
    210                 215                 220                 


Tyr Ala Phe Ala Ile Ile Ile Met Ser Ile Ile Ser Ile Ser Leu Thr 
225                 230                 235                 240 


Val Tyr Asp Leu Arg Glu Gln Ser Val Lys Leu His His Leu Val Glu 
                245                 250                 255     


Ser His Asn Ser Ile Thr Val Ser Val Cys Gly Arg Lys Ala Gly Val 
            260                 265                 270         


Gln Glu Leu Glu Ser Arg Val Leu Val Pro Gly Asp Leu Leu Ile Leu 
        275                 280                 285             


Thr Gly Asn Lys Val Leu Met Pro Cys Asp Ala Val Leu Ile Glu Gly 
    290                 295                 300                 


Ser Cys Val Val Asp Glu Gly Met Leu Thr Gly Glu Ser Ile Pro Val 
305                 310                 315                 320 


Thr Lys Thr Pro Leu Pro Lys Met Asp Ser Ser Val Pro Trp Lys Thr 
                325                 330                 335     


Gln Ser Glu Ala Asp Tyr Lys Arg His Val Leu Phe Cys Gly Thr Glu 
            340                 345                 350         


Val Ile Gln Ala Lys Ala Ala Cys Ser Gly Thr Val Arg Ala Val Val 
        355                 360                 365             


Leu Gln Thr Gly Phe Asn Thr Ala Lys Gly Asp Leu Val Arg Ser Ile 
    370                 375                 380                 


Leu Tyr Pro Lys Pro Val Asn Phe Gln Leu Tyr Arg Asp Ala Ile Arg 
385                 390                 395                 400 


Phe Leu Leu Cys Leu Val Gly Thr Ala Thr Ile Gly Met Ile Tyr Thr 
                405                 410                 415     


Leu Cys Val Tyr Val Leu Ser Gly Glu Pro Pro Glu Glu Val Val Arg 
            420                 425                 430         


Lys Ala Leu Asp Val Ile Thr Ile Ala Val Pro Pro Ala Leu Pro Ala 
        435                 440                 445             


Ala Leu Thr Thr Gly Ile Ile Tyr Ala Gln Arg Arg Leu Lys Lys Arg 
    450                 455                 460                 


Gly Ile Phe Cys Ile Ser Pro Gln Arg Ile Asn Val Cys Gly Gln Leu 
465                 470                 475                 480 


Asn Leu Val Cys Phe Asp Lys Thr Gly Thr Leu Thr Arg Asp Gly Leu 
                485                 490                 495     


Asp Leu Trp Gly Val Val Ser Cys Asp Arg Asn Gly Phe Gln Glu Val 
            500                 505                 510         


His Ser Phe Ala Ser Gly Gln Ala Leu Pro Trp Gly Pro Leu Cys Ala 
        515                 520                 525             


Ala Met Ala Ser Cys His Ser Leu Ile Leu Leu Asp Gly Thr Ile Gln 
    530                 535                 540                 


Gly Asp Pro Leu Asp Leu Lys Met Phe Glu Ala Thr Thr Trp Glu Met 
545                 550                 555                 560 


Ala Phe Ser Gly Asp Asp Phe His Ile Lys Gly Val Pro Ala His Ala 
                565                 570                 575     


Met Val Val Lys Pro Cys Arg Thr Ala Ser Gln Val Pro Val Glu Gly 
            580                 585                 590         


Ile Ala Ile Leu His Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met 
        595                 600                 605             


Thr Val Ile Val Gln Glu Met Gly Gly Asp Arg Leu Ala Phe Met Lys 
    610                 615                 620                 


Gly Ala Pro Glu Arg Val Ala Ser Phe Cys Gln Pro Glu Thr Val Pro 
625                 630                 635                 640 


Thr Ser Phe Val Ser Glu Leu Gln Ile Tyr Thr Thr Gln Gly Phe Arg 
                645                 650                 655     


Val Ile Ala Leu Ala Tyr Lys Lys Leu Glu Asn Asp His His Ala Thr 
            660                 665                 670         


Thr Leu Thr Arg Glu Thr Val Glu Ser Asp Leu Ile Phe Leu Gly Leu 
        675                 680                 685             


Leu Ile Leu Glu Asn Arg Leu Lys Glu Glu Thr Lys Pro Val Leu Glu 
    690                 695                 700                 


Glu Leu Ile Ser Ala Arg Ile Arg Thr Val Met Ile Thr Gly Asp Asn 
705                 710                 715                 720 


Leu Gln Thr Ala Ile Thr Val Ala Arg Lys Ser Gly Met Val Ser Glu 
                725                 730                 735     


Ser Gln Lys Val Ile Leu Ile Glu Ala Asn Glu Thr Thr Gly Ser Ser 
            740                 745                 750         


Ser Ala Ser Ile Ser Trp Thr Leu Val Glu Glu Lys Lys His Ile Met 
        755                 760                 765             


Tyr Gly Asn Gln Asp Asn Tyr Ile Asn Ile Arg Asp Glu Val Ser Asp 
    770                 775                 780                 


Lys Gly Arg Glu Gly Ser Tyr His Phe Ala Leu Thr Gly Lys Ser Phe 
785                 790                 795                 800 


His Val Ile Ser Gln His Phe Ser Ser Leu Leu Pro Lys Ile Leu Ile 
                805                 810                 815     


Asn Gly Thr Ile Phe Ala Arg Met Ser Pro Gly Gln Lys Ser Ser Leu 
            820                 825                 830         


Val Glu Glu Phe Gln Lys Leu Asp Tyr Phe Val Gly Met Cys Gly Asp 
        835                 840                 845             


Gly Ala Asn Asp Cys Gly Ala Leu Lys Met Ala His Val Gly Ile Ser 
    850                 855                 860                 


Leu Ser Glu Gln Glu Ala Ser Val Ala Ser Pro Phe Thr Ser Lys Thr 
865                 870                 875                 880 


Pro Asn Ile Glu Cys Val Pro His Leu Ile Lys Glu Gly Arg Ala Ala 
                885                 890                 895     


Leu Val Thr Ser Phe Cys Met Phe Lys Tyr Met Ala Leu Tyr Ser Met 
            900                 905                 910         


Ile Gln Tyr Val Gly Val Leu Leu Leu Tyr Trp Glu Thr Asn Ser Leu 
        915                 920                 925             


Ser Asn Tyr Gln Phe Leu Phe Gln Asp Leu Ala Ile Thr Thr Leu Ile 
    930                 935                 940                 


Gly Val Thr Met Asn Leu Asn Gly Ala Tyr Pro Lys Leu Val Pro Phe 
945                 950                 955                 960 


Arg Pro Ala Gly Arg Leu Ile Ser Pro Pro Leu Leu Leu Ser Val Ile 
                965                 970                 975     


Phe Asn Ile Leu Leu Ser Leu Ala Met His Ile Ala Gly Phe Ile Leu 
            980                 985                 990         


Val Gln Arg Gln Pro Trp Tyr Ser  Val Glu Ile His Ser  Ala Cys Thr 
        995                 1000                 1005             


Val Gln  Asn Glu Ser Ile Ser  Glu Leu Thr Met Ser  Pro Thr Ala 
    1010                 1015                 1020             


Pro Glu  Lys Met Glu Ser Asn  Ser Thr Phe Thr Ser  Phe Glu Asn 
    1025                 1030                 1035             


Thr Thr  Val Trp Phe Leu Gly  Thr Ile Asn Cys Ile  Thr Val Ala 
    1040                 1045                 1050             


Leu Val  Phe Ser Lys Gly Lys  Pro Phe Arg Gln Pro  Thr Tyr Thr 
    1055                 1060                 1065             


Asn Tyr  Ile Phe Val Leu Val  Leu Ile Ile Gln Leu  Gly Val Cys 
    1070                 1075                 1080             


Leu Phe  Ile Leu Phe Ala Asp  Ile Pro Glu Leu Tyr  Arg Arg Leu 
    1085                 1090                 1095             


Asp Leu  Leu Cys Thr Pro Val  Leu Trp Arg Ala Ser  Ile Val Ile 
    1100                 1105                 1110             


Met Leu  Ser Leu Asn Phe Ile  Val Ser Leu Val Ala  Glu Glu Ala 
    1115                 1120                 1125             


Val Ile  Glu Asn Arg Ala Leu  Trp Met Met Ile Lys  Arg Cys Phe 
    1130                 1135                 1140             


Gly Tyr  Gln Ser Lys Ser Gln  Tyr Arg Ile Trp Gln  Arg Asp Leu 
    1145                 1150                 1155             


Ala Asn  Asp Pro Ser Trp Pro  Pro Leu Asn Gln Thr  Ser His Ser 
    1160                 1165                 1170             


Asp Met  Pro Glu Cys Gly Arg  Gly Val Ser Tyr Ser  Asn Pro Val 
    1175                 1180                 1185             


Phe Glu  Ser Asn Glu Glu Gln  Leu 
    1190                 1195     


<210>  914
<211>  1020
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP1A2__Homo_sapiens__NP_000693

<400>  914

Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala 
1               5                   10                  15      


Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu 
            20                  25                  30          


Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu 
        35                  40                  45              


Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln 
    50                  55                  60                  


Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro 
65                  70                  75                  80  


Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly 
                85                  90                  95      


Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala 
            100                 105                 110         


Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met 
                165                 170                 175     


Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His 
        275                 280                 285             


Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp 
                405                 410                 415     


Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys 
            420                 425                 430         


Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser 
    450                 455                 460                 


Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser 
                485                 490                 495     


Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp 
        515                 520                 525             


Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly 
545                 550                 555                 560 


Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro 
                565                 570                 575     


Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu 
865                 870                 875                 880 


Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Ile Tyr Asp Glu  Val Arg Lys Leu Ile  Leu Arg Arg 
        995                 1000                 1005             


Tyr Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210>  915
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP1A3__Homo_sapiens__NP_001243142

<400>  915

Met Gly Gly Trp Glu Glu Glu Arg Asn Arg Arg Ala Thr Asp Lys Lys 
1               5                   10                  15      


Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly Lys Glu Arg Arg Asp 
            20                  25                  30          


Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr Glu His Lys Met Ser 
        35                  40                  45              


Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp Cys Val Gln Gly Leu 
    50                  55                  60                  


Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala 
65                  70                  75                  80  


Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln 
                85                  90                  95      


Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys 
            100                 105                 110         


Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu Asp Asp Pro Ser Gly 
        115                 120                 125             


Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala Val Val Ile Ile Thr 
    130                 135                 140                 


Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu 
145                 150                 155                 160 


Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly 
                165                 170                 175     


Glu Lys Met Gln Val Asn Ala Glu Glu Val Val Val Gly Asp Leu Val 
            180                 185                 190         


Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser 
        195                 200                 205             


Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu 
    210                 215                 220                 


Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp Asn Pro Leu Glu Thr 
225                 230                 235                 240 


Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg 
                245                 250                 255     


Gly Val Val Val Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala 
            260                 265                 270         


Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr Pro Ile Ala Ile Glu 
        275                 280                 285             


Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly 
    290                 295                 300                 


Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly Tyr Thr Trp Leu Glu 
305                 310                 315                 320 


Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly 
                325                 330                 335     


Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met 
            340                 345                 350         


Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu 
        355                 360                 365             


Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln 
    370                 375                 380                 


Asn Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu 
385                 390                 395                 400 


Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser Phe Asp Lys Ser Ser 
                405                 410                 415     


His Thr Trp Val Ala Leu Ser His Ile Ala Gly Leu Cys Asn Arg Ala 
            420                 425                 430         


Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val Leu Lys Arg Asp Val 
        435                 440                 445             


Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser 
    450                 455                 460                 


Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn Lys Lys Val Ala Glu 
465                 470                 475                 480 


Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Thr 
                485                 490                 495     


Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val Met Lys Gly Ala Pro 
            500                 505                 510         


Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu Leu Gln Gly Lys Glu 
        515                 520                 525             


Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe Gln Asn Ala Tyr Leu 
    530                 535                 540                 


Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Tyr Tyr 
545                 550                 555                 560 


Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala Phe Asp Cys Asp Asp 
                565                 570                 575     


Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val Gly Leu Met Ser Met 
            580                 585                 590         


Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg 
        595                 600                 605             


Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr 
    610                 615                 620                 


Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu 
625                 630                 635                 640 


Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val 
                645                 650                 655     


Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His Gly Thr Asp Leu Lys 
            660                 665                 670         


Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu Gln Asn His Thr Glu 
        675                 680                 685             


Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu 
    690                 695                 700                 


Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val 
705                 710                 715                 720 


Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly 
                725                 730                 735     


Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu 
            740                 745                 750         


Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu 
        755                 760                 765             


Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn 
    770                 775                 780                 


Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile Met Ala Asn Ile Pro 
785                 790                 795                 800 


Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp 
                805                 810                 815     


Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile 
            820                 825                 830         


Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp Lys Leu Val Asn Glu 
        835                 840                 845             


Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu 
    850                 855                 860                 


Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu 
865                 870                 875                 880 


Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp Asp Asp Arg Thr Val 
                885                 890                 895     


Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg 
            900                 905                 910         


Lys Val Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val 
        915                 920                 925             


Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser 
    930                 935                 940                 


Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe 
945                 950                 955                 960 


Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Asp 
                965                 970                 975     


Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser Trp Trp Phe Cys Ala 
            980                 985                 990         


Phe Pro Tyr Ser Phe Leu Ile Phe  Val Tyr Asp Glu Ile  Arg Lys Leu 
        995                 1000                 1005             


Ile Leu  Arg Arg Asn Pro Gly  Gly Trp Val Glu Lys  Glu Thr Tyr 
    1010                 1015                 1020             


Tyr 
    


<210>  916
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP1A4__Homo_sapiens__NP_001001734

<400>  916

Met Ile Gln Ala Leu Ala Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala 
1               5                   10                  15      


Glu Asn Gly Phe Arg Pro Val Asp Leu Leu Gly Ile Arg Leu His Trp 
            20                  25                  30          


Glu Asp Lys Tyr Leu Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
        35                  40                  45              


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys Gln Thr Ala Phe 
    50                  55                  60                  


Phe Val Thr Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Ser Lys 
65                  70                  75                  80  


Thr Arg Arg Asn Ser Leu Phe Gln Gln Gly Met Arg Asn Lys Val Leu 
                85                  90                  95      


Ile Phe Gly Ile Leu Glu Glu Thr Leu Leu Ala Ala Phe Leu Ser Tyr 
            100                 105                 110         


Thr Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Ile Thr 
        115                 120                 125             


Trp Trp Leu Cys Ala Ile Pro Tyr Ser Ile Leu Ile Phe Val Tyr Asp 
    130                 135                 140                 


Glu Ile Arg Lys Leu Leu Ile Arg Gln His Pro Asp Gly Trp Val Glu 
145                 150                 155                 160 


Arg Glu Thr Tyr Tyr 
                165 


<210>  917
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP1B1__Homo_sapiens__NP_001668

<400>  917

Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
1               5                   10                  15      


Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
            20                  25                  30          


Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
        35                  40                  45              


Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Phe 
    50                  55                  60                  


Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
65                  70                  75                  80  


Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                85                  90                  95      


Ser Tyr Glu Ala Tyr Val Leu Asn Ile Val Arg Phe Leu Glu Lys Tyr 
            100                 105                 110         


Lys Asp Ser Ala Gln Arg Asp Asp Met Ile Phe Glu Asp Cys Gly Asp 
        115                 120                 125             


Val Pro Ser Glu Pro Lys Glu Arg Gly Asp Phe Asn His Glu Arg Gly 
    130                 135                 140                 


Glu Arg Lys Val Cys Arg Phe Lys Leu Glu Trp Leu Gly Asn Cys Ser 
145                 150                 155                 160 


Gly Leu Asn Asp Glu Thr Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                165                 170                 175     


Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
            180                 185                 190         


Asn Glu Ser Leu Glu Thr Tyr Pro Val Met Lys Tyr Asn Pro Asn Val 
        195                 200                 205             


Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys Val 
    210                 215                 220                 


Gly Asn Val Glu Tyr Phe Gly Leu Gly Asn Ser Pro Gly Phe Pro Leu 
225                 230                 235                 240 


Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu Gln 
                245                 250                 255     


Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Met Asp Thr Glu Ile 
            260                 265                 270         


Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu Lys 
        275                 280                 285             


Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
    290                 295                 300             


<210>  918
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP1B2__Homo_sapiens__NP_001669

<400>  918

Met Val Ile Gln Lys Glu Lys Lys Ser Cys Gly Gln Val Val Glu Glu 
1               5                   10                  15      


Trp Lys Glu Phe Val Trp Asn Pro Arg Thr His Gln Phe Met Gly Arg 
            20                  25                  30          


Thr Gly Thr Ser Trp Ala Phe Ile Leu Leu Phe Tyr Leu Val Phe Tyr 
        35                  40                  45              


Gly Phe Leu Thr Ala Met Phe Thr Leu Thr Met Trp Val Met Leu Gln 
    50                  55                  60                  


Thr Val Ser Asp His Thr Pro Lys Tyr Gln Asp Arg Leu Ala Thr Pro 
65                  70                  75                  80  


Gly Leu Met Ile Arg Pro Lys Thr Glu Asn Leu Asp Val Ile Val Asn 
                85                  90                  95      


Val Ser Asp Thr Glu Ser Trp Asp Gln His Val Gln Lys Leu Asn Lys 
            100                 105                 110         


Phe Leu Glu Pro Tyr Asn Asp Ser Ile Gln Ala Gln Lys Asn Asp Val 
        115                 120                 125             


Cys Arg Pro Gly Arg Tyr Tyr Glu Gln Pro Asp Asn Gly Val Leu Asn 
    130                 135                 140                 


Tyr Pro Lys Arg Ala Cys Gln Phe Asn Arg Thr Gln Leu Gly Asn Cys 
145                 150                 155                 160 


Ser Gly Ile Gly Asp Ser Thr His Tyr Gly Tyr Ser Thr Gly Gln Pro 
                165                 170                 175     


Cys Val Phe Ile Lys Met Asn Arg Val Ile Asn Phe Tyr Ala Gly Ala 
            180                 185                 190         


Asn Gln Ser Met Asn Val Thr Cys Ala Gly Lys Arg Asp Glu Asp Ala 
        195                 200                 205             


Glu Asn Leu Gly Asn Phe Val Met Phe Pro Ala Asn Gly Asn Ile Asp 
    210                 215                 220                 


Leu Met Tyr Phe Pro Tyr Tyr Gly Lys Lys Phe His Val Asn Tyr Thr 
225                 230                 235                 240 


Gln Pro Leu Val Ala Val Lys Phe Leu Asn Val Thr Pro Asn Val Glu 
                245                 250                 255     


Val Asn Val Glu Cys Arg Ile Asn Ala Ala Asn Ile Ala Thr Asp Asp 
            260                 265                 270         


Glu Arg Asp Lys Phe Ala Gly Arg Val Ala Phe Lys Leu Arg Ile Asn 
        275                 280                 285             


Lys Thr 
    290 


<210>  919
<211>  869
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2A1__Homo_sapiens__NP_001273004

<400>  919

Met Gly Lys Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys 
1               5                   10                  15      


Ala Arg Asp Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp 
            20                  25                  30          


Lys Val Pro Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Thr Thr Leu 
        35                  40                  45              


Arg Val Asp Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys 
    50                  55                  60                  


His Thr Glu Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys 
65                  70                  75                  80  


Asn Met Leu Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Leu Gly 
                85                  90                  95      


Ile Val Ala Thr Thr Gly Val Gly Thr Glu Ile Gly Lys Ile Arg Asp 
            100                 105                 110         


Gln Met Ala Ala Thr Glu Gln Asp Lys Thr Pro Leu Gln Gln Lys Leu 
        115                 120                 125             


Asp Glu Phe Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val 
    130                 135                 140                 


Ala Val Trp Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly 
145                 150                 155                 160 


Gly Ser Trp Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala 
                165                 170                 175     


Leu Ala Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr 
            180                 185                 190         


Cys Leu Ala Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val 
        195                 200                 205             


Arg Ser Leu Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys 
    210                 215                 220                 


Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Lys 
225                 230                 235                 240 


Met Phe Ile Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu 
                245                 250                 255     


Phe Ser Ile Thr Gly Ser Thr Tyr Ala Pro Glu Gly Glu Val Leu Lys 
            260                 265                 270         


Asn Asp Lys Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu 
        275                 280                 285             


Ala Thr Ile Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu 
    290                 295                 300                 


Ala Lys Gly Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu 
305                 310                 315                 320 


Thr Thr Leu Val Glu Lys Met Asn Val Phe Asn Thr Asp Val Arg Ser 
                325                 330                 335     


Leu Ser Lys Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln 
            340                 345                 350         


Leu Met Lys Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser 
        355                 360                 365             


Met Ser Val Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly 
    370                 375                 380                 


Asn Lys Met Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys 
385                 390                 395                 400 


Asn Tyr Val Arg Val Gly Thr Thr Arg Val Pro Leu Thr Gly Pro Val 
                405                 410                 415     


Lys Glu Lys Ile Met Ala Val Ile Lys Glu Trp Gly Thr Gly Arg Asp 
            420                 425                 430         


Thr Leu Arg Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Lys Arg 
        435                 440                 445             


Glu Glu Met Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Thr 
    450                 455                 460                 


Asp Leu Thr Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys 
465                 470                 475                 480 


Glu Val Thr Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val 
                485                 490                 495     


Ile Met Ile Thr Gly Asp Asn Lys Gly Thr Ala Ile Ala Ile Cys Arg 
            500                 505                 510         


Arg Ile Gly Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr 
        515                 520                 525             


Thr Gly Arg Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala 
    530                 535                 540                 


Cys Arg Arg Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser 
545                 550                 555                 560 


Lys Ile Val Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Thr Ala Met Thr 
                565                 570                 575     


Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly 
            580                 585                 590         


Ile Ala Met Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met 
        595                 600                 605             


Val Leu Ala Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu 
    610                 615                 620                 


Gly Arg Ala Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile 
625                 630                 635                 640 


Ser Ser Asn Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu 
                645                 650                 655     


Gly Leu Pro Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu 
            660                 665                 670         


Val Thr Asp Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp 
        675                 680                 685             


Leu Asp Ile Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile 
    690                 695                 700                 


Ser Gly Trp Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly 
705                 710                 715                 720 


Ala Ala Thr Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp 
                725                 730                 735     


Gly Pro His Val Asn Tyr Ser Gln Leu Thr His Phe Met Gln Cys Thr 
            740                 745                 750         


Glu Asp Asn Thr His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala 
        755                 760                 765             


Pro Glu Pro Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met 
    770                 775                 780                 


Cys Asn Ala Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met 
785                 790                 795                 800 


Pro Pro Trp Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met 
                805                 810                 815     


Ser Leu His Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe 
            820                 825                 830         


Lys Leu Arg Ala Leu Asp Leu Thr Gln Trp Leu Met Val Leu Lys Ile 
        835                 840                 845             


Ser Leu Pro Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg 
    850                 855                 860                 


Asn Tyr Leu Glu Gly 
865                 


<210>  920
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2A2__Homo_sapiens__NP_001672

<400>  920

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  921
<211>  1052
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2A3__Homo_sapiens__NP_777613

<400>  921

Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe 
1               5                   10                  15      


Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala 
            20                  25                  30          


Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser 
        35                  40                  45              


Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu 
            180                 185                 190         


Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val 
    210                 215                 220                 


Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala 
225                 230                 235                 240 


Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp 
            260                 265                 270         


Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp 
        275                 280                 285             


Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val 
        355                 360                 365             


Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile 
    370                 375                 380                 


Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln 
385                 390                 395                 400 


Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg 
    450                 455                 460                 


Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met 
            500                 505                 510         


Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val 
        515                 520                 525             


Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln 
    530                 535                 540                 


Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg 
545                 550                 555                 560 


Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met 
                565                 570                 575     


Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr 
            580                 585                 590         


Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala 
        595                 600                 605             


Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile 
    610                 615                 620                 


Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly 
625                 630                 635                 640 


Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg 
                645                 650                 655     


Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr 
            660                 665                 670         


Ala Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val 
        675                 680                 685             


Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly 
    690                 695                 700                 


Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met 
705                 710                 715                 720 


Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser 
                725                 730                 735     


Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala 
            740                 745                 750         


Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn 
        755                 760                 765             


Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro 
    770                 775                 780                 


Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp 
785                 790                 795                 800 


Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile 
                805                 810                 815     


Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp 
            820                 825                 830         


Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr 
        835                 840                 845             


Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His 
    850                 855                 860                 


Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn 
865                 870                 875                 880 


Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro 
                885                 890                 895     


Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala 
            900                 905                 910         


Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp 
        915                 920                 925             


Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His 
    930                 935                 940                 


Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr 
945                 950                 955                 960 


Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro 
                965                 970                 975     


Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met 
            980                 985                 990         


His Ala Cys Leu Tyr Pro Gly Leu  Leu Arg Thr Val Ser  Gln Ala Trp 
        995                 1000                 1005             


Ser Arg  Gln Pro Leu Thr Thr  Ser Trp Thr Pro Asp  His Thr Gly 
    1010                 1015                 1020             


Leu Ala  Ser Leu Gly Gln Gly  His Ser Ile Val Ser  Leu Ser Glu 
    1025                 1030                 1035             


Leu Leu  Arg Glu Gly Gly Ser  Arg Glu Glu Met Ser  Gln Lys 
    1040                 1045                 1050         


<210>  922
<211>  1220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2B1__Homo_sapiens__XP_011536710

<400>  922

Met Gly Asp Met Ala Asn Asn Ser Val Ala Tyr Ser Gly Val Lys Asn 
1               5                   10                  15      


Ser Leu Lys Glu Ala Asn His Asp Gly Asp Phe Gly Ile Thr Leu Ala 
            20                  25                  30          


Glu Leu Arg Ala Leu Met Glu Leu Arg Ser Thr Asp Ala Leu Arg Lys 
        35                  40                  45              


Ile Gln Glu Ser Tyr Gly Asp Val Tyr Gly Ile Cys Thr Lys Leu Lys 
    50                  55                  60                  


Thr Ser Pro Asn Glu Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Arg 
65                  70                  75                  80  


Arg Glu Ala Val Phe Gly Lys Asn Phe Ile Pro Pro Lys Lys Pro Lys 
                85                  90                  95      


Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
            100                 105                 110         


Ile Leu Glu Ile Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Gln 
        115                 120                 125             


Pro Pro Glu Gly Asp Asn Ala Leu Cys Gly Glu Val Ser Val Gly Glu 
    130                 135                 140                 


Glu Glu Gly Glu Gly Glu Thr Gly Trp Ile Glu Gly Ala Ala Ile Leu 
145                 150                 155                 160 


Leu Ser Val Val Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser 
                165                 170                 175     


Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln 
            180                 185                 190         


Lys Phe Thr Val Ile Arg Gly Gly Gln Val Ile Gln Ile Pro Val Ala 
        195                 200                 205             


Asp Ile Thr Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu 
    210                 215                 220                 


Pro Ala Asp Gly Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu 
225                 230                 235                 240 


Ser Ser Leu Thr Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys 
                245                 250                 255     


Asp Pro Leu Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg 
            260                 265                 270         


Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe 
        275                 280                 285             


Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Glu Lys 
    290                 295                 300                 


Lys Lys Glu Lys Lys Asn Lys Lys Gln Asp Gly Ala Ile Glu Asn Arg 
305                 310                 315                 320 


Asn Lys Ala Lys Ala Gln Asp Gly Ala Ala Met Glu Met Gln Pro Leu 
                325                 330                 335     


Lys Ser Glu Glu Gly Gly Asp Gly Asp Glu Lys Asp Lys Lys Lys Ala 
            340                 345                 350         


Asn Leu Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys 
        355                 360                 365             


Leu Ala Val Gln Ile Gly Lys Ala Gly Leu Leu Met Ser Ala Ile Thr 
    370                 375                 380                 


Val Ile Ile Leu Val Leu Tyr Phe Val Ile Asp Thr Phe Trp Val Gln 
385                 390                 395                 400 


Lys Arg Pro Trp Leu Ala Glu Cys Thr Pro Ile Tyr Ile Gln Tyr Phe 
                405                 410                 415     


Val Lys Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro 
            420                 425                 430         


Glu Gly Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys 
        435                 440                 445             


Lys Met Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu 
    450                 455                 460                 


Thr Met Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu 
465                 470                 475                 480 


Thr Met Asn Arg Met Thr Val Val Gln Ala Tyr Ile Asn Glu Lys His 
                485                 490                 495     


Tyr Lys Lys Val Pro Glu Pro Glu Ala Ile Pro Pro Asn Ile Leu Ser 
            500                 505                 510         


Tyr Leu Val Thr Gly Ile Ser Val Asn Cys Ala Tyr Thr Ser Lys Ile 
        515                 520                 525             


Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro Arg His Val Gly Asn Lys 
    530                 535                 540                 


Thr Glu Cys Ala Leu Leu Gly Leu Leu Leu Asp Leu Lys Arg Asp Tyr 
545                 550                 555                 560 


Gln Asp Val Arg Asn Glu Ile Pro Glu Glu Ala Leu Tyr Lys Val Tyr 
                565                 570                 575     


Thr Phe Asn Ser Val Arg Lys Ser Met Ser Thr Val Leu Lys Asn Ser 
            580                 585                 590         


Asp Gly Ser Tyr Arg Ile Phe Ser Lys Gly Ala Ser Glu Ile Ile Leu 
        595                 600                 605             


Lys Lys Cys Phe Lys Ile Leu Ser Ala Asn Gly Glu Ala Lys Val Phe 
    610                 615                 620                 


Arg Pro Arg Asp Arg Asp Asp Ile Val Lys Thr Val Ile Glu Pro Met 
625                 630                 635                 640 


Ala Ser Glu Gly Leu Arg Thr Ile Cys Leu Ala Phe Arg Asp Phe Pro 
                645                 650                 655     


Ala Gly Glu Pro Glu Pro Glu Trp Asp Asn Glu Asn Asp Ile Val Thr 
            660                 665                 670         


Gly Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro 
        675                 680                 685             


Glu Val Pro Asp Ala Ile Lys Lys Cys Gln Arg Ala Gly Ile Thr Val 
    690                 695                 700                 


Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Thr 
705                 710                 715                 720 


Lys Cys Gly Ile Leu His Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly 
                725                 730                 735     


Lys Asp Phe Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln 
            740                 745                 750         


Glu Arg Ile Asp Lys Ile Trp Pro Lys Leu Arg Val Leu Ala Arg Ser 
        755                 760                 765             


Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr 
    770                 775                 780                 


Val Ser Asp Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn 
785                 790                 795                 800 


Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile 
                805                 810                 815     


Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp 
            820                 825                 830         


Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val 
        835                 840                 845             


Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val 
    850                 855                 860                 


Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser 
865                 870                 875                 880 


Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr 
                885                 890                 895     


Leu Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu 
            900                 905                 910         


Leu Arg Lys Pro Tyr Gly Arg Asn Lys Pro Leu Ile Ser Arg Thr Met 
        915                 920                 925             


Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu Val Val Val Phe 
    930                 935                 940                 


Thr Leu Leu Phe Ala Gly Glu Lys Phe Phe Asp Ile Asp Ser Gly Arg 
945                 950                 955                 960 


Asn Ala Pro Leu His Ala Pro Pro Ser Glu His Tyr Thr Ile Val Phe 
                965                 970                 975     


Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys 
            980                 985                 990         


Ile His Gly Glu Arg Asn Val Phe  Glu Gly Ile Phe Asn  Asn Ala Ile 
        995                 1000                 1005             


Phe Cys  Thr Ile Val Leu Gly  Thr Phe Val Val Gln  Ile Ile Ile 
    1010                 1015                 1020             


Val Gln  Phe Gly Gly Lys Pro  Phe Ser Cys Ser Glu  Leu Ser Ile 
    1025                 1030                 1035             


Glu Gln  Trp Leu Trp Ser Ile  Phe Leu Gly Met Gly  Thr Leu Leu 
    1040                 1045                 1050             


Trp Gly  Gln Leu Ile Ser Thr  Ile Pro Thr Ser Arg  Leu Lys Phe 
    1055                 1060                 1065             


Leu Lys  Glu Ala Gly His Gly  Thr Gln Lys Glu Glu  Ile Pro Glu 
    1070                 1075                 1080             


Glu Glu  Leu Ala Glu Asp Val  Glu Glu Ile Asp His  Ala Glu Arg 
    1085                 1090                 1095             


Glu Leu  Arg Arg Gly Gln Ile  Leu Trp Phe Arg Gly  Leu Asn Arg 
    1100                 1105                 1110             


Ile Gln  Thr Gln Ile Arg Val  Val Asn Ala Phe Arg  Ser Ser Leu 
    1115                 1120                 1125             


Tyr Glu  Gly Leu Glu Lys Pro  Glu Ser Arg Ser Ser  Ile His Asn 
    1130                 1135                 1140             


Phe Met  Thr His Pro Glu Phe  Arg Ile Glu Asp Ser  Glu Pro His 
    1145                 1150                 1155             


Ile Pro  Leu Ile Asp Asp Thr  Asp Ala Glu Asp Asp  Ala Pro Thr 
    1160                 1165                 1170             


Lys Arg  Asn Ser Ser Pro Pro  Pro Ser Pro Asn Lys  Asn Asn Asn 
    1175                 1180                 1185             


Ala Val  Asp Ser Gly Ile His  Leu Thr Ile Glu Met  Asn Lys Ser 
    1190                 1195                 1200             


Ala Thr  Ser Ser Ser Pro Gly  Ser Pro Leu His Ser  Leu Glu Thr 
    1205                 1210                 1215             


Ser Leu  
    1220 


<210>  923
<211>  1243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2B2__Homo_sapiens__NP_001001331

<400>  923

Met Gly Asp Met Thr Asn Ser Asp Phe Tyr Ser Lys Asn Gln Arg Asn 
1               5                   10                  15      


Glu Ser Ser His Gly Gly Glu Phe Gly Cys Thr Met Glu Glu Leu Arg 
            20                  25                  30          


Ser Leu Met Glu Leu Arg Gly Thr Glu Ala Val Val Lys Ile Lys Glu 
        35                  40                  45              


Thr Tyr Gly Asp Thr Glu Ala Ile Cys Arg Arg Leu Lys Thr Ser Pro 
    50                  55                  60                  


Val Glu Gly Leu Pro Gly Thr Ala Pro Asp Leu Glu Lys Arg Lys Gln 
65                  70                  75                  80  


Ile Phe Gly Gln Asn Phe Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu 
                85                  90                  95      


Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu 
            100                 105                 110         


Ile Ala Ala Ile Ile Ser Leu Gly Leu Ser Phe Tyr His Pro Pro Gly 
        115                 120                 125             


Glu Gly Asn Glu Gly Cys Ala Thr Ala Gln Gly Gly Ala Glu Asp Glu 
    130                 135                 140                 


Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Leu Ser 
145                 150                 155                 160 


Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu 
                165                 170                 175     


Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu Gln Lys Phe 
            180                 185                 190         


Thr Val Val Arg Ala Gly Gln Val Val Gln Ile Pro Val Ala Glu Ile 
        195                 200                 205             


Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala 
    210                 215                 220                 


Asp Gly Leu Phe Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser 
225                 230                 235                 240 


Leu Thr Gly Glu Ser Asp Gln Val Arg Lys Ser Val Asp Lys Asp Pro 
                245                 250                 255     


Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Leu 
            260                 265                 270         


Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Phe Thr Leu 
        275                 280                 285             


Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys Lys Gly Val 
    290                 295                 300                 


Lys Lys Gly Asp Gly Leu Gln Leu Pro Ala Ala Asp Gly Ala Ala Ala 
305                 310                 315                 320 


Ser Asn Ala Ala Asp Ser Ala Asn Ala Ser Leu Val Asn Gly Lys Met 
                325                 330                 335     


Gln Asp Gly Asn Val Asp Ala Ser Gln Ser Lys Ala Lys Gln Gln Asp 
            340                 345                 350         


Gly Ala Ala Ala Met Glu Met Gln Pro Leu Lys Ser Ala Glu Gly Gly 
        355                 360                 365             


Asp Ala Asp Asp Arg Lys Lys Ala Ser Met His Lys Lys Glu Lys Ser 
    370                 375                 380                 


Val Leu Gln Gly Lys Leu Thr Lys Leu Ala Val Gln Ile Gly Lys Ala 
385                 390                 395                 400 


Gly Leu Val Met Ser Ala Ile Thr Val Ile Ile Leu Val Leu Tyr Phe 
                405                 410                 415     


Thr Val Asp Thr Phe Val Val Asn Lys Lys Pro Trp Leu Pro Glu Cys 
            420                 425                 430         


Thr Pro Val Tyr Val Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Val 
        435                 440                 445             


Thr Val Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr 
    450                 455                 460                 


Ile Ser Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu 
465                 470                 475                 480 


Val Arg His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile 
                485                 490                 495     


Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr Asn Arg Met Thr Val Val 
            500                 505                 510         


Gln Ala Tyr Val Gly Asp Val His Tyr Lys Glu Ile Pro Asp Pro Ser 
        515                 520                 525             


Ser Ile Asn Thr Lys Thr Met Glu Leu Leu Ile Asn Ala Ile Ala Ile 
    530                 535                 540                 


Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro Pro Glu Lys Glu Gly Ala 
545                 550                 555                 560 


Leu Pro Arg Gln Val Gly Asn Lys Thr Glu Cys Gly Leu Leu Gly Phe 
                565                 570                 575     


Val Leu Asp Leu Lys Gln Asp Tyr Glu Pro Val Arg Ser Gln Met Pro 
            580                 585                 590         


Glu Glu Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser 
        595                 600                 605             


Met Ser Thr Val Ile Lys Leu Pro Asp Glu Ser Phe Arg Met Tyr Ser 
    610                 615                 620                 


Lys Gly Ala Ser Glu Ile Val Leu Lys Lys Cys Cys Lys Ile Leu Asn 
625                 630                 635                 640 


Gly Ala Gly Glu Pro Arg Val Phe Arg Pro Arg Asp Arg Asp Glu Met 
                645                 650                 655     


Val Lys Lys Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile 
            660                 665                 670         


Cys Val Ala Tyr Arg Asp Phe Pro Ser Ser Pro Glu Pro Asp Trp Asp 
        675                 680                 685             


Asn Glu Asn Asp Ile Leu Asn Glu Leu Thr Cys Ile Cys Val Val Gly 
    690                 695                 700                 


Ile Glu Asp Pro Val Arg Pro Glu Val Pro Glu Ala Ile Arg Lys Cys 
705                 710                 715                 720 


Gln Arg Ala Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn 
                725                 730                 735     


Thr Ala Arg Ala Ile Ala Ile Lys Cys Gly Ile Ile His Pro Gly Glu 
            740                 745                 750         


Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe Asn Arg Arg Ile Arg Asn 
        755                 760                 765             


Glu Lys Gly Glu Ile Glu Gln Glu Arg Ile Asp Lys Ile Trp Pro Lys 
    770                 775                 780                 


Leu Arg Val Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val 
785                 790                 795                 800 


Lys Gly Ile Ile Asp Ser Thr His Thr Glu Gln Arg Gln Val Val Ala 
                805                 810                 815     


Val Thr Gly Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp 
            820                 825                 830         


Val Gly Phe Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala 
        835                 840                 845             


Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe Ser Ser Ile Val Lys Ala 
    850                 855                 860                 


Val Met Trp Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln 
865                 870                 875                 880 


Phe Gln Leu Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly 
                885                 890                 895     


Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp 
            900                 905                 910         


Val Asn Leu Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu 
        915                 920                 925             


Pro Pro Thr Glu Thr Leu Leu Leu Arg Lys Pro Tyr Gly Arg Asn Lys 
    930                 935                 940                 


Pro Leu Ile Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Val 
945                 950                 955                 960 


Tyr Gln Leu Ala Leu Ile Phe Thr Leu Leu Phe Val Gly Glu Lys Met 
                965                 970                 975     


Phe Gln Ile Asp Ser Gly Arg Asn Ala Pro Leu His Ser Pro Pro Ser 
            980                 985                 990         


Glu His Tyr Thr Ile Ile Phe Asn  Thr Phe Val Met Met  Gln Leu Phe 
        995                 1000                 1005             


Asn Glu  Ile Asn Ala Arg Lys  Ile His Gly Glu Arg  Asn Val Phe 
    1010                 1015                 1020             


Asp Gly  Ile Phe Arg Asn Pro  Ile Phe Cys Thr Ile  Val Leu Gly 
    1025                 1030                 1035             


Thr Phe  Ala Ile Gln Ile Val  Ile Val Gln Phe Gly  Gly Lys Pro 
    1040                 1045                 1050             


Phe Ser  Cys Ser Pro Leu Gln  Leu Asp Gln Trp Met  Trp Cys Ile 
    1055                 1060                 1065             


Phe Ile  Gly Leu Gly Glu Leu  Val Trp Gly Gln Val  Ile Ala Thr 
    1070                 1075                 1080             


Ile Pro  Thr Ser Arg Leu Lys  Phe Leu Lys Glu Ala  Gly Arg Leu 
    1085                 1090                 1095             


Thr Gln  Lys Glu Glu Ile Pro  Glu Glu Glu Leu Asn  Glu Asp Val 
    1100                 1105                 1110             


Glu Glu  Ile Asp His Ala Glu  Arg Glu Leu Arg Arg  Gly Gln Ile 
    1115                 1120                 1125             


Leu Trp  Phe Arg Gly Leu Asn  Arg Ile Gln Thr Gln  Ile Arg Val 
    1130                 1135                 1140             


Val Lys  Ala Phe Arg Ser Ser  Leu Tyr Glu Gly Leu  Glu Lys Pro 
    1145                 1150                 1155             


Glu Ser  Arg Thr Ser Ile His  Asn Phe Met Ala His  Pro Glu Phe 
    1160                 1165                 1170             


Arg Ile  Glu Asp Ser Gln Pro  His Ile Pro Leu Ile  Asp Asp Thr 
    1175                 1180                 1185             


Asp Leu  Glu Glu Asp Ala Ala  Leu Lys Gln Asn Ser  Ser Pro Pro 
    1190                 1195                 1200             


Ser Ser  Leu Asn Lys Asn Asn  Ser Ala Ile Asp Ser  Gly Ile Asn 
    1205                 1210                 1215             


Leu Thr  Thr Asp Thr Ser Lys  Ser Ala Thr Ser Ser  Ser Pro Gly 
    1220                 1225                 1230             


Ser Pro  Ile His Ser Leu Glu  Thr Ser Leu 
    1235                 1240             


<210>  924
<211>  1220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2B3__Homo_sapiens__XP_005274747

<400>  924

Met Gly Asp Met Ala Asn Ser Ser Ile Glu Phe His Pro Lys Pro Gln 
1               5                   10                  15      


Gln Gln Arg Asp Val Pro Gln Ala Gly Gly Phe Gly Cys Thr Leu Ala 
            20                  25                  30          


Glu Leu Arg Thr Leu Met Glu Leu Arg Gly Ala Glu Ala Leu Gln Lys 
        35                  40                  45              


Ile Glu Glu Ala Tyr Gly Asp Val Ser Gly Leu Cys Arg Arg Leu Lys 
    50                  55                  60                  


Thr Ser Pro Thr Glu Gly Leu Ala Asp Asn Thr Asn Asp Leu Glu Lys 
65                  70                  75                  80  


Arg Arg Gln Ile Tyr Gly Gln Asn Phe Ile Pro Pro Lys Gln Pro Lys 
                85                  90                  95      


Thr Phe Leu Gln Leu Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile 
            100                 105                 110         


Ile Leu Glu Val Ala Ala Ile Val Ser Leu Gly Leu Ser Phe Tyr Ala 
        115                 120                 125             


Pro Pro Gly Glu Glu Ser Glu Ala Cys Gly Asn Val Ser Gly Gly Ala 
    130                 135                 140                 


Glu Asp Glu Gly Glu Ala Glu Ala Gly Trp Ile Glu Gly Ala Ala Ile 
145                 150                 155                 160 


Leu Leu Ser Val Ile Cys Val Val Leu Val Thr Ala Phe Asn Asp Trp 
                165                 170                 175     


Ser Lys Glu Lys Gln Phe Arg Gly Leu Gln Ser Arg Ile Glu Gln Glu 
            180                 185                 190         


Gln Lys Phe Thr Val Ile Arg Asn Gly Gln Leu Leu Gln Val Pro Val 
        195                 200                 205             


Ala Ala Leu Val Val Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu 
    210                 215                 220                 


Leu Pro Ala Asp Gly Val Leu Ile Gln Ala Asn Asp Leu Lys Ile Asp 
225                 230                 235                 240 


Glu Ser Ser Leu Thr Gly Glu Ser Asp His Val Arg Lys Ser Ala Asp 
                245                 250                 255     


Lys Asp Pro Met Leu Leu Ser Gly Thr His Val Met Glu Gly Ser Gly 
            260                 265                 270         


Arg Met Val Val Thr Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile 
        275                 280                 285             


Phe Thr Leu Leu Gly Ala Gly Gly Glu Glu Glu Glu Lys Lys Asp Lys 
    290                 295                 300                 


Lys Gly Lys Gln Gln Asp Gly Ala Met Glu Ser Ser Gln Thr Lys Ala 
305                 310                 315                 320 


Lys Lys Gln Asp Gly Ala Val Ala Met Glu Met Gln Pro Leu Lys Ser 
                325                 330                 335     


Ala Glu Gly Gly Glu Met Glu Glu Arg Glu Lys Lys Lys Ala Asn Ala 
            340                 345                 350         


Pro Lys Lys Glu Lys Ser Val Leu Gln Gly Lys Leu Thr Lys Leu Ala 
        355                 360                 365             


Val Gln Ile Gly Lys Ala Gly Leu Val Met Ser Ala Ile Thr Val Ile 
    370                 375                 380                 


Ile Leu Val Leu Tyr Phe Val Ile Glu Thr Phe Val Val Glu Gly Arg 
385                 390                 395                 400 


Thr Trp Leu Ala Glu Cys Thr Pro Val Tyr Val Gln Tyr Phe Val Lys 
                405                 410                 415     


Phe Phe Ile Ile Gly Val Thr Val Leu Val Val Ala Val Pro Glu Gly 
            420                 425                 430         


Leu Pro Leu Ala Val Thr Ile Ser Leu Ala Tyr Ser Val Lys Lys Met 
        435                 440                 445             


Met Lys Asp Asn Asn Leu Val Arg His Leu Asp Ala Cys Glu Thr Met 
    450                 455                 460                 


Gly Asn Ala Thr Ala Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Thr 
465                 470                 475                 480 


Asn Arg Met Thr Val Val Gln Ser Tyr Leu Gly Asp Thr His Tyr Lys 
                485                 490                 495     


Glu Ile Pro Ala Pro Ser Ala Leu Thr Pro Lys Ile Leu Asp Leu Leu 
            500                 505                 510         


Val His Ala Ile Ser Ile Asn Ser Ala Tyr Thr Thr Lys Ile Leu Pro 
        515                 520                 525             


Pro Glu Lys Glu Gly Ala Leu Pro Arg Gln Val Gly Asn Lys Thr Glu 
    530                 535                 540                 


Cys Ala Leu Leu Gly Phe Val Leu Asp Leu Lys Arg Asp Phe Gln Pro 
545                 550                 555                 560 


Val Arg Glu Gln Ile Pro Glu Asp Lys Leu Tyr Lys Val Tyr Thr Phe 
                565                 570                 575     


Asn Ser Val Arg Lys Ser Met Ser Thr Val Ile Arg Met Pro Asp Gly 
            580                 585                 590         


Gly Phe Arg Leu Phe Ser Lys Gly Ala Ser Glu Ile Leu Leu Lys Lys 
        595                 600                 605             


Cys Thr Asn Ile Leu Asn Ser Asn Gly Glu Leu Arg Gly Phe Arg Pro 
    610                 615                 620                 


Arg Asp Arg Asp Asp Met Val Arg Lys Ile Ile Glu Pro Met Ala Cys 
625                 630                 635                 640 


Asp Gly Leu Arg Thr Ile Cys Ile Ala Tyr Arg Asp Phe Ser Ala Gly 
                645                 650                 655     


Gln Glu Pro Asp Trp Asp Asn Glu Asn Glu Val Val Gly Asp Leu Thr 
            660                 665                 670         


Cys Ile Ala Val Val Gly Ile Glu Asp Pro Val Arg Pro Glu Val Pro 
        675                 680                 685             


Glu Ala Ile Arg Lys Cys Gln Arg Ala Gly Ile Thr Val Arg Met Val 
    690                 695                 700                 


Thr Gly Asp Asn Ile Asn Thr Ala Arg Ala Ile Ala Ala Lys Cys Gly 
705                 710                 715                 720 


Ile Ile Gln Pro Gly Glu Asp Phe Leu Cys Leu Glu Gly Lys Glu Phe 
                725                 730                 735     


Asn Arg Arg Ile Arg Asn Glu Lys Gly Glu Ile Glu Gln Glu Arg Leu 
            740                 745                 750         


Asp Lys Val Trp Pro Lys Leu Arg Val Leu Ala Arg Ser Ser Pro Thr 
        755                 760                 765             


Asp Lys His Thr Leu Val Lys Gly Ile Ile Asp Ser Thr Thr Gly Glu 
    770                 775                 780                 


Gln Arg Gln Val Val Ala Val Thr Gly Asp Gly Thr Asn Asp Gly Pro 
785                 790                 795                 800 


Ala Leu Lys Lys Ala Asp Val Gly Phe Ala Met Gly Ile Ala Gly Thr 
                805                 810                 815     


Asp Val Ala Lys Glu Ala Ser Asp Ile Ile Leu Thr Asp Asp Asn Phe 
            820                 825                 830         


Thr Ser Ile Val Lys Ala Val Met Trp Gly Arg Asn Val Tyr Asp Ser 
        835                 840                 845             


Ile Ser Lys Phe Leu Gln Phe Gln Leu Thr Val Asn Val Val Ala Val 
    850                 855                 860                 


Ile Val Ala Phe Thr Gly Ala Cys Ile Thr Gln Asp Ser Pro Leu Lys 
865                 870                 875                 880 


Ala Val Gln Met Leu Trp Val Asn Leu Ile Met Asp Thr Phe Ala Ser 
                885                 890                 895     


Leu Ala Leu Ala Thr Glu Pro Pro Thr Glu Ser Leu Leu Leu Arg Lys 
            900                 905                 910         


Pro Tyr Gly Arg Asp Lys Pro Leu Ile Ser Arg Thr Met Met Lys Asn 
        915                 920                 925             


Ile Leu Gly His Ala Val Tyr Gln Leu Ala Ile Ile Phe Thr Leu Leu 
    930                 935                 940                 


Phe Val Gly Glu Leu Phe Phe Asp Ile Asp Ser Gly Arg Asn Ala Pro 
945                 950                 955                 960 


Leu His Ser Pro Pro Ser Glu His Tyr Thr Ile Ile Phe Asn Thr Phe 
                965                 970                 975     


Val Met Met Gln Leu Phe Asn Glu Ile Asn Ala Arg Lys Ile His Gly 
            980                 985                 990         


Glu Arg Asn Val Phe Asp Gly Ile  Phe Ser Asn Pro Ile  Phe Cys Thr 
        995                 1000                 1005             


Ile Val  Leu Gly Thr Phe Gly  Ile Gln Ile Val Ile  Val Gln Phe 
    1010                 1015                 1020             


Gly Gly  Lys Pro Phe Ser Cys  Ser Pro Leu Ser Thr  Glu Gln Trp 
    1025                 1030                 1035             


Leu Trp  Cys Leu Phe Val Gly  Val Gly Glu Leu Val  Trp Gly Gln 
    1040                 1045                 1050             


Val Ile  Ala Thr Ile Pro Thr  Ser Gln Leu Lys Cys  Leu Lys Glu 
    1055                 1060                 1065             


Ala Gly  His Gly Pro Gly Lys  Asp Glu Met Thr Asp  Glu Glu Leu 
    1070                 1075                 1080             


Ala Glu  Gly Glu Glu Glu Ile  Asp His Ala Glu Arg  Glu Leu Arg 
    1085                 1090                 1095             


Arg Gly  Gln Ile Leu Trp Phe  Arg Gly Leu Asn Arg  Ile Gln Thr 
    1100                 1105                 1110             


Gln Ile  Arg Val Val Lys Ala  Phe Arg Ser Ser Leu  Tyr Glu Gly 
    1115                 1120                 1125             


Leu Glu  Lys Pro Glu Ser Lys  Thr Ser Ile His Asn  Phe Met Ala 
    1130                 1135                 1140             


Thr Pro  Glu Phe Leu Ile Asn  Asp Tyr Thr His Asn  Ile Pro Leu 
    1145                 1150                 1155             


Ile Asp  Asp Thr Asp Val Asp  Glu Asn Glu Glu Arg  Leu Arg Ala 
    1160                 1165                 1170             


Pro Pro  Pro Pro Ser Pro Asn  Gln Asn Asn Asn Ala  Ile Asp Ser 
    1175                 1180                 1185             


Gly Ile  Tyr Leu Thr Thr His  Val Thr Lys Ser Ala  Thr Ser Ser 
    1190                 1195                 1200             


Val Phe  Ser Ser Ser Pro Gly  Ser Pro Leu His Ser  Val Glu Thr 
    1205                 1210                 1215             


Ser Leu  
    1220 


<210>  925
<211>  1170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2B4__Homo_sapiens__NP_001001396

<400>  925

Met Thr Asn Pro Ser Asp Arg Val Leu Pro Ala Asn Ser Met Ala Glu 
1               5                   10                  15      


Ser Arg Glu Gly Asp Phe Gly Cys Thr Val Met Glu Leu Arg Lys Leu 
            20                  25                  30          


Met Glu Leu Arg Ser Arg Asp Ala Leu Thr Gln Ile Asn Val His Tyr 
        35                  40                  45              


Gly Gly Val Gln Asn Leu Cys Ser Arg Leu Lys Thr Ser Pro Val Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asn Pro Ala Asp Leu Glu Lys Arg Arg Gln Val Phe 
65                  70                  75                  80  


Gly His Asn Val Ile Pro Pro Lys Lys Pro Lys Thr Phe Leu Glu Leu 
                85                  90                  95      


Val Trp Glu Ala Leu Gln Asp Val Thr Leu Ile Ile Leu Glu Ile Ala 
            100                 105                 110         


Ala Ile Ile Ser Leu Val Leu Ser Phe Tyr Arg Pro Ala Gly Glu Glu 
        115                 120                 125             


Asn Glu Leu Cys Gly Gln Val Ala Thr Thr Pro Glu Asp Glu Asn Glu 
    130                 135                 140                 


Ala Gln Ala Gly Trp Ile Glu Gly Ala Ala Ile Leu Phe Ser Val Ile 
145                 150                 155                 160 


Ile Val Val Leu Val Thr Ala Phe Asn Asp Trp Ser Lys Glu Lys Gln 
                165                 170                 175     


Phe Arg Gly Leu Gln Cys Arg Ile Glu Gln Glu Gln Lys Phe Ser Ile 
            180                 185                 190         


Ile Arg Asn Gly Gln Leu Ile Gln Leu Pro Val Ala Glu Ile Val Val 
        195                 200                 205             


Gly Asp Ile Ala Gln Val Lys Tyr Gly Asp Leu Leu Pro Ala Asp Gly 
    210                 215                 220                 


Ile Leu Ile Gln Gly Asn Asp Leu Lys Ile Asp Glu Ser Ser Leu Thr 
225                 230                 235                 240 


Gly Glu Ser Asp His Val Lys Lys Ser Leu Asp Lys Asp Pro Met Leu 
                245                 250                 255     


Leu Ser Gly Thr His Val Met Glu Gly Ser Gly Arg Met Val Val Thr 
            260                 265                 270         


Ala Val Gly Val Asn Ser Gln Thr Gly Ile Ile Leu Thr Leu Leu Gly 
        275                 280                 285             


Val Asn Glu Asp Asp Glu Gly Glu Lys Lys Lys Lys Gly Lys Lys Gln 
    290                 295                 300                 


Gly Val Pro Glu Asn Arg Asn Lys Ala Lys Thr Gln Asp Gly Val Ala 
305                 310                 315                 320 


Leu Glu Ile Gln Pro Leu Asn Ser Gln Glu Gly Ile Asp Asn Glu Glu 
                325                 330                 335     


Lys Asp Lys Lys Ala Val Lys Val Pro Lys Lys Glu Lys Ser Val Leu 
            340                 345                 350         


Gln Gly Lys Leu Thr Arg Leu Ala Val Gln Ile Gly Lys Ala Gly Leu 
        355                 360                 365             


Leu Met Ser Ala Leu Thr Val Phe Ile Leu Ile Leu Tyr Phe Val Ile 
    370                 375                 380                 


Asp Asn Phe Val Ile Asn Arg Arg Pro Trp Leu Pro Glu Cys Thr Pro 
385                 390                 395                 400 


Ile Tyr Ile Gln Tyr Phe Val Lys Phe Phe Ile Ile Gly Ile Thr Val 
                405                 410                 415     


Leu Val Val Ala Val Pro Glu Gly Leu Pro Leu Ala Val Thr Ile Ser 
            420                 425                 430         


Leu Ala Tyr Ser Val Lys Lys Met Met Lys Asp Asn Asn Leu Val Arg 
        435                 440                 445             


His Leu Asp Ala Cys Glu Thr Met Gly Asn Ala Thr Ala Ile Cys Ser 
    450                 455                 460                 


Asp Lys Thr Gly Thr Leu Thr Met Asn Arg Met Thr Val Val Gln Ala 
465                 470                 475                 480 


Tyr Ile Gly Gly Ile His Tyr Arg Gln Ile Pro Ser Pro Asp Val Phe 
                485                 490                 495     


Leu Pro Lys Val Leu Asp Leu Ile Val Asn Gly Ile Ser Ile Asn Ser 
            500                 505                 510         


Ala Tyr Thr Ser Lys Ile Leu Pro Pro Glu Lys Glu Gly Gly Leu Pro 
        515                 520                 525             


Arg Gln Val Gly Asn Lys Thr Glu Cys Ala Leu Leu Gly Phe Val Thr 
    530                 535                 540                 


Asp Leu Lys Gln Asp Tyr Gln Ala Val Arg Asn Glu Val Pro Glu Glu 
545                 550                 555                 560 


Lys Leu Tyr Lys Val Tyr Thr Phe Asn Ser Val Arg Lys Ser Met Ser 
                565                 570                 575     


Thr Val Ile Arg Asn Pro Asn Gly Gly Phe Arg Met Tyr Ser Lys Gly 
            580                 585                 590         


Ala Ser Glu Ile Ile Leu Arg Lys Cys Asn Arg Ile Leu Asp Arg Lys 
        595                 600                 605             


Gly Glu Ala Val Pro Phe Lys Asn Lys Asp Arg Asp Asp Met Val Arg 
    610                 615                 620                 


Thr Val Ile Glu Pro Met Ala Cys Asp Gly Leu Arg Thr Ile Cys Ile 
625                 630                 635                 640 


Ala Tyr Arg Asp Phe Asp Asp Thr Glu Pro Ser Trp Asp Asn Glu Asn 
                645                 650                 655     


Glu Ile Leu Thr Glu Leu Thr Cys Ile Ala Val Val Gly Ile Glu Asp 
            660                 665                 670         


Pro Val Arg Pro Glu Val Pro Asp Ala Ile Ala Lys Cys Lys Gln Ala 
        675                 680                 685             


Gly Ile Thr Val Arg Met Val Thr Gly Asp Asn Ile Asn Thr Ala Arg 
    690                 695                 700                 


Ala Ile Ala Thr Lys Cys Gly Ile Leu Thr Pro Gly Asp Asp Phe Leu 
705                 710                 715                 720 


Cys Leu Glu Gly Lys Glu Phe Asn Arg Leu Ile Arg Asn Glu Lys Gly 
                725                 730                 735     


Glu Val Glu Gln Glu Lys Leu Asp Lys Ile Trp Pro Lys Leu Arg Val 
            740                 745                 750         


Leu Ala Arg Ser Ser Pro Thr Asp Lys His Thr Leu Val Lys Gly Ile 
        755                 760                 765             


Ile Asp Ser Thr Val Gly Glu His Arg Gln Val Val Ala Val Thr Gly 
    770                 775                 780                 


Asp Gly Thr Asn Asp Gly Pro Ala Leu Lys Lys Ala Asp Val Gly Phe 
785                 790                 795                 800 


Ala Met Gly Ile Ala Gly Thr Asp Val Ala Lys Glu Ala Ser Asp Ile 
                805                 810                 815     


Ile Leu Thr Asp Asp Asn Phe Thr Ser Ile Val Lys Ala Val Met Trp 
            820                 825                 830         


Gly Arg Asn Val Tyr Asp Ser Ile Ser Lys Phe Leu Gln Phe Gln Leu 
        835                 840                 845             


Thr Val Asn Val Val Ala Val Ile Val Ala Phe Thr Gly Ala Cys Ile 
    850                 855                 860                 


Thr Gln Asp Ser Pro Leu Lys Ala Val Gln Met Leu Trp Val Asn Leu 
865                 870                 875                 880 


Ile Met Asp Thr Phe Ala Ser Leu Ala Leu Ala Thr Glu Pro Pro Thr 
                885                 890                 895     


Glu Ser Leu Leu Lys Arg Arg Pro Tyr Gly Arg Asn Lys Pro Leu Ile 
            900                 905                 910         


Ser Arg Thr Met Met Lys Asn Ile Leu Gly His Ala Phe Tyr Gln Leu 
        915                 920                 925             


Ile Val Ile Phe Ile Leu Val Phe Ala Gly Glu Lys Phe Phe Asp Ile 
    930                 935                 940                 


Asp Ser Gly Arg Lys Ala Pro Leu His Ser Pro Pro Ser Gln His Tyr 
945                 950                 955                 960 


Thr Ile Val Phe Asn Thr Phe Val Leu Met Gln Leu Phe Asn Glu Ile 
                965                 970                 975     


Asn Ser Arg Lys Ile His Gly Glu Lys Asn Val Phe Ser Gly Ile Tyr 
            980                 985                 990         


Arg Asn Ile Ile Phe Cys Ser Val  Val Leu Gly Thr Phe  Ile Cys Gln 
        995                 1000                 1005             


Ile Phe  Ile Val Glu Phe Gly  Gly Lys Pro Phe Ser  Cys Thr Ser 
    1010                 1015                 1020             


Leu Ser  Leu Ser Gln Trp Leu  Trp Cys Leu Phe Ile  Gly Ile Gly 
    1025                 1030                 1035             


Glu Leu  Leu Trp Gly Gln Phe  Ile Ser Ala Ile Pro  Thr Arg Ser 
    1040                 1045                 1050             


Leu Lys  Phe Leu Lys Glu Ala  Gly His Gly Thr Thr  Lys Glu Glu 
    1055                 1060                 1065             


Ile Thr  Lys Asp Ala Glu Gly  Leu Asp Glu Ile Asp  His Ala Glu 
    1070                 1075                 1080             


Met Glu  Leu Arg Arg Gly Gln  Ile Leu Trp Phe Arg  Gly Leu Asn 
    1085                 1090                 1095             


Arg Ile  Gln Thr Gln Ile Asp  Val Ile Asn Thr Phe  Gln Thr Gly 
    1100                 1105                 1110             


Ala Ser  Phe Lys Gly Val Leu  Arg Arg Gln Asn Met  Gly Gln His 
    1115                 1120                 1125             


Leu Asp  Val Lys Leu Val Pro  Ser Ser Ser Tyr Val  Ala Val Ala 
    1130                 1135                 1140             


Pro Val  Lys Ser Ser Pro Thr  Thr Ser Val Pro Ala  Val Ser Ser 
    1145                 1150                 1155             


Pro Pro  Met Gly Asn Gln Ser  Gly Gln Ser Val Pro  
    1160                 1165                 1170 


<210>  926
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2C1__Homo_sapiens__NP_001001486

<400>  926

Met Lys Val Ala Arg Phe Gln Lys Ile Pro Asn Gly Glu Asn Glu Thr 
1               5                   10                  15      


Met Ile Pro Val Leu Thr Ser Lys Lys Ala Ser Glu Leu Pro Val Ser 
            20                  25                  30          


Glu Val Ala Ser Ile Leu Gln Ala Asp Leu Gln Asn Gly Leu Asn Lys 
        35                  40                  45              


Cys Glu Val Ser His Arg Arg Ala Phe His Gly Trp Asn Glu Phe Asp 
    50                  55                  60                  


Ile Ser Glu Asp Glu Pro Leu Trp Lys Lys Tyr Ile Ser Gln Phe Lys 
65                  70                  75                  80  


Asn Pro Leu Ile Met Leu Leu Leu Ala Ser Ala Val Ile Ser Val Leu 
                85                  90                  95      


Met His Gln Phe Asp Asp Ala Val Ser Ile Thr Val Ala Ile Leu Ile 
            100                 105                 110         


Val Val Thr Val Ala Phe Val Gln Glu Tyr Arg Ser Glu Lys Ser Leu 
        115                 120                 125             


Glu Glu Leu Ser Lys Leu Val Pro Pro Glu Cys His Cys Val Arg Glu 
    130                 135                 140                 


Gly Lys Leu Glu His Thr Leu Ala Arg Asp Leu Val Pro Gly Asp Thr 
145                 150                 155                 160 


Val Cys Leu Ser Val Gly Asp Arg Val Pro Ala Asp Leu Arg Leu Phe 
                165                 170                 175     


Glu Ala Val Asp Leu Ser Ile Asp Glu Ser Ser Leu Thr Gly Glu Thr 
            180                 185                 190         


Thr Pro Cys Ser Lys Val Thr Ala Pro Gln Pro Ala Ala Thr Asn Gly 
        195                 200                 205             


Asp Leu Ala Ser Arg Ser Asn Ile Ala Phe Met Gly Thr Leu Val Arg 
    210                 215                 220                 


Cys Gly Lys Ala Lys Gly Val Val Ile Gly Thr Gly Glu Asn Ser Glu 
225                 230                 235                 240 


Phe Gly Glu Val Phe Lys Met Met Gln Ala Glu Glu Ala Pro Lys Thr 
                245                 250                 255     


Pro Leu Gln Lys Ser Met Asp Leu Leu Gly Lys Gln Leu Ser Phe Tyr 
            260                 265                 270         


Ser Phe Gly Ile Ile Gly Ile Ile Met Leu Val Gly Trp Leu Leu Gly 
        275                 280                 285             


Lys Asp Ile Leu Glu Met Phe Thr Ile Ser Val Ser Leu Ala Val Ala 
    290                 295                 300                 


Ala Ile Pro Glu Gly Leu Pro Ile Val Val Thr Val Thr Leu Ala Leu 
305                 310                 315                 320 


Gly Val Met Arg Met Val Lys Lys Arg Ala Ile Val Lys Lys Leu Pro 
                325                 330                 335     


Ile Val Glu Thr Leu Gly Cys Cys Asn Val Ile Cys Ser Asp Lys Thr 
            340                 345                 350         


Gly Thr Leu Thr Lys Asn Glu Met Thr Val Thr His Ile Phe Thr Ser 
        355                 360                 365             


Asp Gly Leu His Ala Glu Val Thr Gly Val Gly Tyr Asn Gln Phe Gly 
    370                 375                 380                 


Glu Val Ile Val Asp Gly Asp Val Val His Gly Phe Tyr Asn Pro Ala 
385                 390                 395                 400 


Val Ser Arg Ile Val Glu Ala Gly Cys Val Cys Asn Asp Ala Val Ile 
                405                 410                 415     


Arg Asn Asn Thr Leu Met Gly Lys Pro Thr Glu Gly Ala Leu Ile Ala 
            420                 425                 430         


Leu Ala Met Lys Met Gly Leu Asp Gly Leu Gln Gln Asp Tyr Ile Arg 
        435                 440                 445             


Lys Ala Glu Tyr Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys 
    450                 455                 460                 


Cys Val His Arg Thr Gln Gln Asp Arg Pro Glu Ile Cys Phe Met Lys 
465                 470                 475                 480 


Gly Ala Tyr Glu Gln Val Ile Lys Tyr Cys Thr Thr Tyr Gln Ser Lys 
                485                 490                 495     


Gly Gln Thr Leu Thr Leu Thr Gln Gln Gln Arg Asp Val Tyr Gln Gln 
            500                 505                 510         


Glu Lys Ala Arg Met Gly Ser Ala Gly Leu Arg Val Leu Ala Leu Ala 
        515                 520                 525             


Ser Gly Pro Glu Leu Gly Gln Leu Thr Phe Leu Gly Leu Val Gly Ile 
    530                 535                 540                 


Ile Asp Pro Pro Arg Thr Gly Val Lys Glu Ala Val Thr Thr Leu Ile 
545                 550                 555                 560 


Ala Ser Gly Val Ser Ile Lys Met Ile Thr Gly Asp Ser Gln Glu Thr 
                565                 570                 575     


Ala Val Ala Ile Ala Ser Arg Leu Gly Leu Tyr Ser Lys Thr Ser Gln 
            580                 585                 590         


Ser Val Ser Gly Glu Glu Ile Asp Ala Met Asp Val Gln Gln Leu Ser 
        595                 600                 605             


Gln Ile Val Pro Lys Val Ala Val Phe Tyr Arg Ala Ser Pro Arg His 
    610                 615                 620                 


Lys Met Lys Ile Ile Lys Ser Leu Gln Lys Asn Gly Ser Val Val Ala 
625                 630                 635                 640 


Met Thr Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ala Ala Asp 
                645                 650                 655     


Ile Gly Val Ala Met Gly Gln Thr Gly Thr Asp Val Cys Lys Glu Ala 
            660                 665                 670         


Ala Asp Met Ile Leu Val Asp Asp Asp Phe Gln Thr Ile Met Ser Ala 
        675                 680                 685             


Ile Glu Glu Gly Lys Gly Ile Tyr Asn Asn Ile Lys Asn Phe Val Arg 
    690                 695                 700                 


Phe Gln Leu Ser Thr Ser Ile Ala Ala Leu Thr Leu Ile Ser Leu Ala 
705                 710                 715                 720 


Thr Leu Met Asn Phe Pro Asn Pro Leu Asn Ala Met Gln Ile Leu Trp 
                725                 730                 735     


Ile Asn Ile Ile Met Asp Gly Pro Pro Ala Gln Ser Leu Gly Val Glu 
            740                 745                 750         


Pro Val Asp Lys Asp Val Ile Arg Lys Pro Pro Arg Asn Trp Lys Asp 
        755                 760                 765             


Ser Ile Leu Thr Lys Asn Leu Ile Leu Lys Ile Leu Val Ser Ser Ile 
    770                 775                 780                 


Ile Ile Val Cys Gly Thr Leu Phe Val Phe Trp Arg Glu Leu Arg Asp 
785                 790                 795                 800 


Asn Val Ile Thr Pro Arg Asp Thr Thr Met Thr Phe Thr Cys Phe Val 
                805                 810                 815     


Phe Phe Asp Met Phe Asn Ala Leu Ser Ser Arg Ser Gln Thr Lys Ser 
            820                 825                 830         


Val Phe Glu Ile Gly Leu Cys Ser Asn Arg Met Phe Cys Tyr Ala Val 
        835                 840                 845             


Leu Gly Ser Ile Met Gly Gln Leu Leu Val Ile Tyr Phe Pro Pro Leu 
    850                 855                 860                 


Gln Lys Val Phe Gln Thr Glu Ser Leu Ser Ile Leu Asp Leu Leu Phe 
865                 870                 875                 880 


Leu Leu Gly Leu Thr Ser Ser Val Cys Ile Val Ala Glu Ile Ile Lys 
                885                 890                 895     


Lys Val Glu Arg Ser Arg Glu Lys Ile Gln Lys His Val Ser Ser Thr 
            900                 905                 910         


Ser Ser Ser Phe Leu Glu Val Trp Leu Trp Glu Arg Ser Gly Gln Gln 
        915                 920                 925             


Leu Val Glu Ile His Pro His Leu Glu Thr Gly Leu Pro Leu Thr Glu 
    930                 935                 940                 


Asp Val Ser Cys Val 
945                 


<210>  927
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP2C2__Homo_sapiens__NP_001273456

<400>  927

Met Val Glu Gly Arg Val Ser Glu Phe Leu Lys Lys Leu Gly Phe Ser 
1               5                   10                  15      


Gly Gly Gly Arg Gln Tyr Gln Ala Leu Glu Lys Asp Glu Glu Glu Ala 
            20                  25                  30          


Leu Ile Asp Glu Gln Ser Glu Leu Lys Ala Ile Glu Lys Glu Lys Lys 
        35                  40                  45              


Val Thr Ala Leu Pro Pro Lys Glu Ala Cys Lys Cys Gln Lys Glu Asp 
    50                  55                  60                  


Leu Ala Arg Ala Phe Cys Val Asp Leu His Thr Gly Leu Ser Glu Phe 
65                  70                  75                  80  


Ser Val Thr Gln Arg Arg Leu Ala His Gly Trp Asn Glu Phe Val Ala 
                85                  90                  95      


Asp Asn Ser Glu Pro Val Trp Lys Lys Tyr Leu Asp Gln Phe Lys Asn 
            100                 105                 110         


Pro Leu Ile Leu Leu Leu Leu Gly Ser Ala Leu Val Ser Val Leu Thr 
        115                 120                 125             


Lys Glu Tyr Glu Asp Ala Val Ser Ile Ala Thr Ala Val Leu Val Val 
    130                 135                 140                 


Val Thr Val Ala Phe Ile Gln Glu Tyr Arg Ser Glu Lys Ser Leu Glu 
145                 150                 155                 160 


Glu Leu Thr Lys Leu Val Pro Pro Glu Cys Asn Cys Leu Arg Glu Gly 
                165                 170                 175     


Lys Leu Gln His Leu Leu Ala Arg Glu Leu Val Pro Gly Asp Val Val 
            180                 185                 190         


Ser Leu Ser Ile Gly Asp Arg Ile Pro Ala Asp Ile Arg Leu Thr Glu 
        195                 200                 205             


Val Thr Asp Leu Leu Val Asp Glu Ser Ser Phe Thr Gly Glu Ala Glu 
    210                 215                 220                 


Pro Cys Ser Lys Thr Asp Ser Pro Leu Thr Gly Gly Gly Asp Leu Thr 
225                 230                 235                 240 


Thr Leu Ser Asn Ile Val Phe Met Gly Thr Leu Val Gln Tyr Gly Arg 
                245                 250                 255     


Gly Gln Gly Val Val Ile Gly Thr Gly Glu Ser Ser Gln Phe Gly Glu 
            260                 265                 270         


Val Phe Lys Met Met Gln Ala Glu Glu Thr Pro Lys Thr Pro Leu Gln 
        275                 280                 285             


Lys Ser Met Asp Arg Leu Gly Lys Gln Leu Thr Leu Phe Ser Phe Gly 
    290                 295                 300                 


Ile Ile Gly Leu Ile Met Leu Ile Gly Trp Ser Gln Gly Lys Gln Leu 
305                 310                 315                 320 


Leu Ser Met Phe Thr Ile Gly Val Ser Leu Ala Val Ala Ala Ile Pro 
                325                 330                 335     


Glu Gly Leu Pro Ile Val Val Met Val Thr Leu Val Leu Gly Val Leu 
            340                 345                 350         


Arg Met Ala Lys Lys Arg Val Ile Val Lys Lys Leu Pro Ile Val Glu 
        355                 360                 365             


Thr Leu Gly Cys Cys Ser Val Leu Cys Ser Asp Lys Thr Gly Thr Leu 
    370                 375                 380                 


Thr Ala Asn Glu Met Thr Val Thr Gln Leu Val Thr Ser Asp Gly Leu 
385                 390                 395                 400 


Arg Ala Glu Val Ser Gly Val Gly Tyr Asp Gly Gln Gly Thr Val Cys 
                405                 410                 415     


Leu Leu Pro Ser Lys Glu Val Ile Lys Glu Phe Ser Asn Val Ser Val 
            420                 425                 430         


Gly Lys Leu Val Glu Ala Gly Cys Val Ala Asn Asn Ala Val Ile Arg 
        435                 440                 445             


Lys Asn Ala Val Met Gly Gln Pro Thr Glu Gly Ala Leu Met Ala Leu 
    450                 455                 460                 


Ala Met Lys Met Asp Leu Ser Asp Ile Lys Asn Ser Tyr Ile Arg Lys 
465                 470                 475                 480 


Lys Glu Ile Pro Phe Ser Ser Glu Gln Lys Trp Met Ala Val Lys Cys 
                485                 490                 495     


Ser Leu Lys Thr Glu Asp Gln Glu Asp Ile Tyr Phe Met Lys Gly Ala 
            500                 505                 510         


Leu Glu Glu Val Ile Arg Tyr Cys Thr Met Tyr Asn Asn Gly Gly Ile 
        515                 520                 525             


Pro Leu Pro Leu Thr Pro Gln Gln Arg Ser Phe Cys Leu Gln Glu Glu 
    530                 535                 540                 


Lys Arg Met Gly Ser Leu Gly Leu Arg Val Leu Ala Leu Ala Ser Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Arg Leu Thr Phe Leu Gly Leu Val Gly Ile Ile Asp 
                565                 570                 575     


Pro Pro Arg Val Gly Val Lys Glu Ala Val Gln Val Leu Ser Glu Ser 
            580                 585                 590         


Gly Val Ser Val Lys Met Ile Thr Gly Asp Ala Leu Glu Thr Ala Leu 
        595                 600                 605             


Ala Ile Gly Arg Asn Ile Gly Leu Cys Asn Gly Lys Leu Gln Ala Met 
    610                 615                 620                 


Ser Gly Glu Glu Val Asp Ser Val Glu Lys Gly Glu Leu Ala Asp Arg 
625                 630                 635                 640 


Val Gly Lys Val Ser Val Phe Phe Arg Thr Ser Pro Lys His Lys Leu 
                645                 650                 655     


Lys Ile Ile Lys Ala Leu Gln Glu Ser Gly Ala Ile Val Ala Met Thr 
            660                 665                 670         


Gly Asp Gly Val Asn Asp Ala Val Ala Leu Lys Ser Ala Asp Ile Gly 
        675                 680                 685             


Ile Ala Met Gly Gln Thr Gly Thr Asp Val Ser Lys Glu Ala Ala Asn 
    690                 695                 700                 


Met Ile Leu Val Asp Asp Asp Phe Ser Ala Ile Met Asn Ala Val Glu 
705                 710                 715                 720 


Glu Gly Lys Gly Ile Phe Tyr Asn Ile Lys Asn Phe Val Arg Phe Gln 
                725                 730                 735     


Leu Ser Thr Ser Ile Ser Ala Leu Ser Leu Ile Thr Leu Ser Thr Val 
            740                 745                 750         


Phe Asn Leu Pro Ser Pro Leu Asn Ala Met Gln Ile Leu Trp Ile Asn 
        755                 760                 765             


Ile Ile Met Asp Gly Pro Pro Ala Gln Arg Ser Ser Gln Lys Thr Glu 
    770                 775                 780                 


Val Cys Cys Thr Ala Val Arg Leu Gly Val Glu Gly Arg Gly Glu Ser 
785                 790                 795                 800 


Thr Trp Ala Gly Arg Ala Gly Leu Gly Val Glu Pro Val Asp Lys Asp 
                805                 810                 815     


Ala Phe Arg Gln Pro Pro Arg Ser Val Arg Asp Thr Ile Leu Ser Arg 
            820                 825                 830         


Ala Leu Ile Leu Lys Ile Leu Met Ser Ala Ala Ile Ile Ile Ser Gly 
        835                 840                 845             


Thr Leu Phe Ile Phe Trp Lys Glu Met Pro Glu Asp Arg Ala Ser Thr 
    850                 855                 860                 


Pro Arg Thr Thr Thr Met Thr Phe Thr Cys Phe Val Phe Phe Asp Leu 
865                 870                 875                 880 


Phe Asn Ala Leu Thr Cys Arg Ser Gln Thr Lys Leu Ile Phe Glu Ile 
                885                 890                 895     


Gly Phe Leu Arg Asn His Met Phe Leu Tyr Ser Val Leu Gly Ser Ile 
            900                 905                 910         


Leu Gly Gln Leu Ala Val Ile Tyr Ile Pro Pro Leu Gln Arg Val Phe 
        915                 920                 925             


Gln Thr Glu Asn Leu Gly Ala Leu Asp Leu Leu Phe Leu Thr Gly Leu 
    930                 935                 940                 


Ala Ser Ser Val Phe Ile Leu Ser Glu Leu Leu Lys Leu Cys Glu Lys 
945                 950                 955                 960 


Tyr Cys Cys Ser Pro Lys Arg Val Gln Met His Pro Glu Asp Val 
                965                 970                 975 


<210>  928
<211>  1035
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP4A__Homo_sapiens__NP_000695

<400>  928

Met Gly Lys Ala Glu Asn Tyr Glu Leu Tyr Ser Val Glu Leu Gly Pro 
1               5                   10                  15      


Gly Pro Gly Gly Asp Met Ala Ala Lys Met Ser Lys Lys Lys Lys Ala 
            20                  25                  30          


Gly Gly Gly Gly Gly Lys Arg Lys Glu Lys Leu Glu Asn Met Lys Lys 
        35                  40                  45              


Glu Met Glu Ile Asn Asp His Gln Leu Ser Val Ala Glu Leu Glu Gln 
    50                  55                  60                  


Lys Tyr Gln Thr Ser Ala Thr Lys Gly Leu Ser Ala Ser Leu Ala Ala 
65                  70                  75                  80  


Glu Leu Leu Leu Arg Asp Gly Pro Asn Ala Leu Arg Pro Pro Arg Gly 
                85                  90                  95      


Thr Pro Glu Tyr Val Lys Phe Ala Arg Gln Leu Ala Gly Gly Leu Gln 
            100                 105                 110         


Cys Leu Met Trp Val Ala Ala Ala Ile Cys Leu Ile Ala Phe Ala Ile 
        115                 120                 125             


Gln Ala Ser Glu Gly Asp Leu Thr Thr Asp Asp Asn Leu Tyr Leu Ala 
    130                 135                 140                 


Ile Ala Leu Ile Ala Val Val Val Val Thr Gly Cys Phe Gly Tyr Tyr 
145                 150                 155                 160 


Gln Glu Phe Lys Ser Thr Asn Ile Ile Ala Ser Phe Lys Asn Leu Val 
                165                 170                 175     


Pro Gln Gln Ala Thr Val Ile Arg Asp Gly Asp Lys Phe Gln Ile Asn 
            180                 185                 190         


Ala Asp Gln Leu Val Val Gly Asp Leu Val Glu Met Lys Gly Gly Asp 
        195                 200                 205             


Arg Val Pro Ala Asp Ile Arg Ile Leu Ala Ala Gln Gly Cys Lys Val 
    210                 215                 220                 


Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro 
225                 230                 235                 240 


Glu Cys Thr His Glu Ser Pro Leu Glu Thr Arg Asn Ile Ala Phe Phe 
                245                 250                 255     


Ser Thr Met Cys Leu Glu Gly Thr Val Gln Gly Leu Val Val Asn Thr 
            260                 265                 270         


Gly Asp Arg Thr Ile Ile Gly Arg Ile Ala Ser Leu Ala Ser Gly Val 
        275                 280                 285             


Glu Asn Glu Lys Thr Pro Ile Ala Ile Glu Ile Glu His Phe Val Asp 
    290                 295                 300                 


Ile Ile Ala Gly Leu Ala Ile Leu Phe Gly Ala Thr Phe Phe Ile Val 
305                 310                 315                 320 


Ala Met Cys Ile Gly Tyr Thr Phe Leu Arg Ala Met Val Phe Phe Met 
                325                 330                 335     


Ala Ile Val Val Ala Tyr Val Pro Glu Gly Leu Leu Ala Thr Val Thr 
            340                 345                 350         


Val Cys Leu Ser Leu Thr Ala Lys Arg Leu Ala Ser Lys Asn Cys Val 
        355                 360                 365             


Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Val Ile 
    370                 375                 380                 


Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ser 
385                 390                 395                 400 


His Leu Trp Phe Asp Asn His Ile His Thr Ala Asp Thr Thr Glu Asp 
                405                 410                 415     


Gln Ser Gly Gln Thr Phe Asp Gln Ser Ser Glu Thr Trp Arg Ala Leu 
            420                 425                 430         


Cys Arg Val Leu Thr Leu Cys Asn Arg Ala Ala Phe Lys Ser Gly Gln 
        435                 440                 445             


Asp Ala Val Pro Val Pro Lys Arg Ile Val Ile Gly Asp Ala Ser Glu 
    450                 455                 460                 


Thr Ala Leu Leu Lys Phe Ser Glu Leu Thr Leu Gly Asn Ala Met Gly 
465                 470                 475                 480 


Tyr Arg Asp Arg Phe Pro Lys Val Cys Glu Ile Pro Phe Asn Ser Thr 
                485                 490                 495     


Asn Lys Phe Gln Leu Ser Ile His Thr Leu Glu Asp Pro Arg Asp Pro 
            500                 505                 510         


Arg His Leu Leu Val Met Lys Gly Ala Pro Glu Arg Val Leu Glu Arg 
        515                 520                 525             


Cys Ser Ser Ile Leu Ile Lys Gly Gln Glu Leu Pro Leu Asp Glu Gln 
    530                 535                 540                 


Trp Arg Glu Ala Phe Gln Thr Ala Tyr Leu Ser Leu Gly Gly Leu Gly 
545                 550                 555                 560 


Glu Arg Val Leu Gly Phe Cys Gln Leu Tyr Leu Asn Glu Lys Asp Tyr 
                565                 570                 575     


Pro Pro Gly Tyr Ala Phe Asp Val Glu Ala Met Asn Phe Pro Ser Ser 
            580                 585                 590         


Gly Leu Cys Phe Ala Gly Leu Val Ser Met Ile Asp Pro Pro Arg Ala 
        595                 600                 605             


Thr Val Pro Asp Ala Val Leu Lys Cys Arg Thr Ala Gly Ile Arg Val 
    610                 615                 620                 


Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Ala 
625                 630                 635                 640 


Ser Val Gly Ile Ile Ser Glu Gly Ser Glu Thr Val Glu Asp Ile Ala 
                645                 650                 655     


Ala Arg Leu Arg Val Pro Val Asp Gln Val Asn Arg Lys Asp Ala Arg 
            660                 665                 670         


Ala Cys Val Ile Asn Gly Met Gln Leu Lys Asp Met Asp Pro Ser Glu 
        675                 680                 685             


Leu Val Glu Ala Leu Arg Thr His Pro Glu Met Val Phe Ala Arg Thr 
    690                 695                 700                 


Ser Pro Gln Gln Lys Leu Val Ile Val Glu Ser Cys Gln Arg Leu Gly 
705                 710                 715                 720 


Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu 
                725                 730                 735     


Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Ala 
            740                 745                 750         


Ala Lys Asn Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser 
        755                 760                 765             


Ile Val Thr Gly Val Glu Gln Gly Arg Leu Ile Phe Asp Asn Leu Lys 
    770                 775                 780                 


Lys Ser Ile Ala Tyr Thr Leu Thr Lys Asn Ile Pro Glu Leu Thr Pro 
785                 790                 795                 800 


Tyr Leu Ile Tyr Ile Thr Val Ser Val Pro Leu Pro Leu Gly Cys Ile 
                805                 810                 815     


Thr Ile Leu Phe Ile Glu Leu Cys Thr Asp Ile Phe Pro Ser Val Ser 
            820                 825                 830         


Leu Ala Tyr Glu Lys Ala Glu Ser Asp Ile Met His Leu Arg Pro Arg 
        835                 840                 845             


Asn Pro Lys Arg Asp Arg Leu Val Asn Glu Pro Leu Ala Ala Tyr Ser 
    850                 855                 860                 


Tyr Phe Gln Ile Gly Ala Ile Gln Ser Phe Ala Gly Phe Thr Asp Tyr 
865                 870                 875                 880 


Phe Thr Ala Met Ala Gln Glu Gly Trp Phe Pro Leu Leu Cys Val Gly 
                885                 890                 895     


Leu Arg Ala Gln Trp Glu Asp His His Leu Gln Asp Leu Gln Asp Ser 
            900                 905                 910         


Tyr Gly Gln Glu Trp Thr Phe Gly Gln Arg Leu Tyr Gln Gln Tyr Thr 
        915                 920                 925             


Cys Tyr Thr Val Phe Phe Ile Ser Ile Glu Val Cys Gln Ile Ala Asp 
    930                 935                 940                 


Val Leu Ile Arg Lys Thr Arg Arg Leu Ser Ala Phe Gln Gln Gly Phe 
945                 950                 955                 960 


Phe Arg Asn Lys Ile Leu Val Ile Ala Ile Val Phe Gln Val Cys Ile 
                965                 970                 975     


Gly Cys Phe Leu Cys Tyr Cys Pro Gly Met Pro Asn Ile Phe Asn Phe 
            980                 985                 990         


Met Pro Ile Arg Phe Gln Trp Trp  Leu Val Pro Leu Pro  Tyr Gly Ile 
        995                 1000                 1005             


Leu Ile  Phe Val Tyr Asp Glu  Ile Arg Lys Leu Gly  Val Arg Cys 
    1010                 1015                 1020             


Cys Pro  Gly Ser Trp Trp Asp  Gln Glu Leu Tyr Tyr  
    1025                 1030                 1035 


<210>  929
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP4B__Homo_sapiens__NP_000696

<400>  929

Met Ala Ala Leu Gln Glu Lys Lys Thr Cys Gly Gln Arg Met Glu Glu 
1               5                   10                  15      


Phe Gln Arg Tyr Cys Trp Asn Pro Asp Thr Gly Gln Met Leu Gly Arg 
            20                  25                  30          


Thr Leu Ser Arg Trp Val Trp Ile Ser Leu Tyr Tyr Val Ala Phe Tyr 
        35                  40                  45              


Val Val Met Thr Gly Leu Phe Ala Leu Cys Leu Tyr Val Leu Met Gln 
    50                  55                  60                  


Thr Val Asp Pro Tyr Thr Pro Asp Tyr Gln Asp Gln Leu Arg Ser Pro 
65                  70                  75                  80  


Gly Val Thr Leu Arg Pro Asp Val Tyr Gly Glu Lys Gly Leu Glu Ile 
                85                  90                  95      


Val Tyr Asn Val Ser Asp Asn Arg Thr Trp Ala Asp Leu Thr Gln Thr 
            100                 105                 110         


Leu His Ala Phe Leu Ala Gly Tyr Ser Pro Ala Ala Gln Glu Asp Ser 
        115                 120                 125             


Ile Asn Cys Thr Ser Glu Gln Tyr Phe Phe Gln Glu Ser Phe Arg Ala 
    130                 135                 140                 


Pro Asn His Thr Lys Phe Ser Cys Lys Phe Thr Ala Asp Met Leu Gln 
145                 150                 155                 160 


Asn Cys Ser Gly Leu Ala Asp Pro Asn Phe Gly Phe Glu Glu Gly Lys 
                165                 170                 175     


Pro Cys Phe Ile Ile Lys Met Asn Arg Ile Val Lys Phe Leu Pro Ser 
            180                 185                 190         


Asn Gly Ser Ala Pro Arg Val Asp Cys Ala Phe Leu Asp Gln Pro Arg 
        195                 200                 205             


Glu Leu Gly Gln Pro Leu Gln Val Lys Tyr Tyr Pro Pro Asn Gly Thr 
    210                 215                 220                 


Phe Ser Leu His Tyr Phe Pro Tyr Tyr Gly Lys Lys Ala Gln Pro His 
225                 230                 235                 240 


Tyr Ser Asn Pro Leu Val Ala Ala Lys Leu Leu Asn Ile Pro Arg Asn 
                245                 250                 255     


Ala Glu Val Ala Ile Val Cys Lys Val Met Ala Glu His Val Thr Phe 
            260                 265                 270         


Asn Asn Pro His Asp Pro Tyr Glu Gly Lys Val Glu Phe Lys Leu Lys 
        275                 280                 285             


Ile Glu Lys 
    290     


<210>  930
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5A1__Homo_sapiens__NP_001001937

<400>  930

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp 
    210                 215                 220                 


Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
225                 230                 235                 240 


Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val 
                245                 250                 255     


Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr 
            260                 265                 270         


Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
        275                 280                 285             


Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
    290                 295                 300                 


Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
305                 310                 315                 320 


Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                325                 330                 335     


Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
            340                 345                 350         


Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro 
        355                 360                 365             


Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn 
    370                 375                 380                 


Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe 
385                 390                 395                 400 


Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                405                 410                 415     


Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr 
            420                 425                 430         


Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
        435                 440                 445             


Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly 
    450                 455                 460                 


Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
465                 470                 475                 480 


Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                485                 490                 495     


Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu 
            500                 505                 510         


Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala 
        515                 520                 525             


Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
    530                 535                 540                 


Thr Asn Phe Leu Ala Gly Phe Glu Ala 
545                 550             


<210>  931
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5B__Homo_sapiens__NP_001677

<400>  931

Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala 
        35                  40                  45              


Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val 
    50                  55                  60                  


Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val 
                85                  90                  95      


Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala 
            100                 105                 110         


Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser 
        115                 120                 125             


Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile 
    130                 135                 140                 


Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr 
145                 150                 155                 160 


Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met 
                165                 170                 175     


Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu 
            180                 185                 190         


Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
        195                 200                 205             


Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala 
    210                 215                 220                 


Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
225                 230                 235                 240 


Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile 
                245                 250                 255     


Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met 
            260                 265                 270         


Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr 
        275                 280                 285             


Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe 
    290                 295                 300                 


Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala 
305                 310                 315                 320 


Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala 
                325                 330                 335     


Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly 
            340                 345                 350         


Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr 
        355                 360                 365             


Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val 
    370                 375                 380                 


Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro 
385                 390                 395                 400 


Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu 
                405                 410                 415     


His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys 
            420                 425                 430         


Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu 
        435                 440                 445             


Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu 
    450                 455                 460                 


Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys 
465                 470                 475                 480 


Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala 
                485                 490                 495     


Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro 
            500                 505                 510         


Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser 
        515                 520                 525             


Ser 
    


<210>  932
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5C1__Homo_sapiens__NP_001001973

<400>  932

Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln 
1               5                   10                  15      


Pro Gln Trp Ile Gln Val Arg Asn Met Ala Thr Leu Lys Asp Ile Thr 
            20                  25                  30          


Arg Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Thr Lys Ser Met 
        35                  40                  45              


Lys Met Val Ala Ala Ala Lys Tyr Ala Arg Ala Glu Arg Glu Leu Lys 
    50                  55                  60                  


Pro Ala Arg Ile Tyr Gly Leu Gly Ser Leu Ala Leu Tyr Glu Lys Ala 
65                  70                  75                  80  


Asp Ile Lys Gly Pro Glu Asp Lys Lys Lys His Leu Leu Ile Gly Val 
                85                  90                  95      


Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys 
            100                 105                 110         


Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val 
        115                 120                 125             


Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Ile Leu Tyr Arg Thr 
    130                 135                 140                 


His Ser Asp Gln Phe Leu Val Ala Phe Lys Glu Val Gly Arg Lys Pro 
145                 150                 155                 160 


Pro Thr Phe Gly Asp Ala Ser Val Ile Ala Leu Glu Leu Leu Asn Ser 
                165                 170                 175     


Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Lys Phe Arg Ser 
            180                 185                 190         


Val Ile Ser Tyr Lys Thr Glu Glu Lys Pro Ile Phe Ser Leu Asn Thr 
        195                 200                 205             


Val Ala Ser Ala Asp Ser Met Ser Ile Tyr Asp Asp Ile Asp Ala Asp 
    210                 215                 220                 


Val Leu Gln Asn Tyr Gln Glu Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr 
225                 230                 235                 240 


Ser Leu Lys Glu Ser Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala 
                245                 250                 255     


Met Asp Asn Ala Ser Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr 
            260                 265                 270         


Leu Thr Phe Asn Arg Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile 
        275                 280                 285             


Glu Ile Ile Ser Gly Ala Ala Ala Leu Asp 
    290                 295             


<210>  933
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5D__Homo_sapiens__NP_001001975

<400>  933

Met Leu Pro Ala Ala Leu Leu Arg Arg Pro Gly Leu Gly Arg Leu Val 
1               5                   10                  15      


Arg His Ala Arg Ala Tyr Ala Glu Ala Ala Ala Ala Pro Ala Ala Ala 
            20                  25                  30          


Ser Gly Pro Asn Gln Met Ser Phe Thr Phe Ala Ser Pro Thr Gln Val 
        35                  40                  45              


Phe Phe Asn Gly Ala Asn Val Arg Gln Val Asp Val Pro Thr Leu Thr 
    50                  55                  60                  


Gly Ala Phe Gly Ile Leu Ala Ala His Val Pro Thr Leu Gln Val Leu 
65                  70                  75                  80  


Arg Pro Gly Leu Val Val Val His Ala Glu Asp Gly Thr Thr Ser Lys 
                85                  90                  95      


Tyr Phe Val Ser Ser Gly Ser Ile Ala Val Asn Ala Asp Ser Ser Val 
            100                 105                 110         


Gln Leu Leu Ala Glu Glu Ala Val Thr Leu Asp Met Leu Asp Leu Gly 
        115                 120                 125             


Ala Ala Lys Ala Asn Leu Glu Lys Ala Gln Ala Glu Leu Val Gly Thr 
    130                 135                 140                 


Ala Asp Glu Ala Thr Arg Ala Glu Ile Gln Ile Arg Ile Glu Ala Asn 
145                 150                 155                 160 


Glu Ala Leu Val Lys Ala Leu Glu 
                165             


<210>  934
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5E__Homo_sapiens__NP_008817

<400>  934

Met Val Ala Tyr Trp Arg Gln Ala Gly Leu Ser Tyr Ile Arg Tyr Ser 
1               5                   10                  15      


Gln Ile Cys Ala Lys Ala Val Arg Asp Ala Leu Lys Thr Glu Phe Lys 
            20                  25                  30          


Ala Asn Ala Glu Lys Thr Ser Gly Ser Asn Val Lys Ile Val Lys Val 
        35                  40                  45              


Lys Lys Glu 
    50      


<210>  935
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5G1__Homo_sapiens__NP_005166

<400>  935

Met Gln Thr Ala Gly Ala Leu Phe Ile Ser Pro Ala Leu Ile Arg Cys 
1               5                   10                  15      


Cys Thr Arg Gly Leu Ile Arg Pro Val Ser Ala Ser Phe Leu Asn Ser 
            20                  25                  30          


Pro Val Asn Ser Ser Lys Gln Pro Ser Tyr Ser Asn Phe Pro Leu Gln 
        35                  40                  45              


Val Ala Arg Arg Glu Phe Gln Thr Ser Val Val Ser Arg Asp Ile Asp 
    50                  55                  60                  


Thr Ala Ala Lys Phe Ile Gly Ala Gly Ala Ala Thr Val Gly Val Ala 
65                  70                  75                  80  


Gly Ser Gly Ala Gly Ile Gly Thr Val Phe Gly Ser Leu Ile Ile Gly 
                85                  90                  95      


Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln Leu Phe Ser Tyr Ala Ile 
            100                 105                 110         


Leu Gly Phe Ala Leu Ser Glu Ala Met Gly Leu Phe Cys Leu Met Val 
        115                 120                 125             


Ala Phe Leu Ile Leu Phe Ala Met 
    130                 135     


<210>  936
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5G2__Homo_sapiens__NP_001002031

<400>  936

Met Pro Glu Leu Ile Leu Ser Pro Ala Thr Ala Pro His Pro Leu Lys 
1               5                   10                  15      


Met Phe Ala Cys Ser Lys Phe Val Ser Thr Pro Ser Leu Val Lys Ser 
            20                  25                  30          


Thr Ser Gln Leu Leu Ser Arg Pro Leu Ser Ala Val Val Leu Lys Arg 
        35                  40                  45              


Pro Glu Ile Leu Thr Asp Glu Ser Leu Ser Ser Leu Ala Val Ser Cys 
    50                  55                  60                  


Pro Leu Thr Ser Leu Val Ser Ser Arg Ser Phe Gln Thr Ser Ala Ile 
65                  70                  75                  80  


Ser Arg Asp Ile Asp Thr Ala Ala Lys Phe Ile Gly Ala Gly Ala Ala 
                85                  90                  95      


Thr Val Gly Val Ala Gly Ser Gly Ala Gly Ile Gly Thr Val Phe Gly 
            100                 105                 110         


Ser Leu Ile Ile Gly Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln Leu 
        115                 120                 125             


Phe Ser Tyr Ala Ile Leu Gly Phe Ala Leu Ser Glu Ala Met Gly Leu 
    130                 135                 140                 


Phe Cys Leu Met Val Ala Phe Leu Ile Leu Phe Ala Met 
145                 150                 155         


<210>  937
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5G3__Homo_sapiens__NP_001002258

<400>  937

Met Phe Ala Cys Ala Lys Leu Ala Cys Thr Pro Ser Leu Ile Arg Ala 
1               5                   10                  15      


Gly Ser Arg Val Ala Tyr Arg Pro Ile Ser Ala Ser Val Leu Ser Arg 
            20                  25                  30          


Pro Glu Ala Ser Arg Thr Gly Glu Gly Ser Thr Val Phe Asn Gly Ala 
        35                  40                  45              


Gln Asn Gly Val Ser Gln Leu Ile Gln Arg Glu Phe Gln Thr Ser Ala 
    50                  55                  60                  


Ile Ser Arg Asp Ile Asp Thr Ala Ala Lys Phe Ile Gly Ala Gly Ala 
65                  70                  75                  80  


Ala Thr Val Gly Val Ala Gly Ser Gly Ala Gly Ile Gly Thr Val Phe 
                85                  90                  95      


Gly Ser Leu Ile Ile Gly Tyr Ala Arg Asn Pro Ser Leu Lys Gln Gln 
            100                 105                 110         


Leu Phe Ser Tyr Ala Ile Leu Gly Phe Ala Leu Ser Glu Ala Met Gly 
        115                 120                 125             


Leu Phe Cys Leu Met Val Ala Phe Leu Ile Leu Phe Ala Met 
    130                 135                 140         


<210>  938
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5H__Homo_sapiens__NP_001003785

<400>  938

Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe 
1               5                   10                  15      


Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys 
            20                  25                  30          


Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn 
        35                  40                  45              


Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala 
    50                  55                  60                  


Gly Leu Val Asp Asp Phe Glu Lys Lys Val Lys Ser Cys Ala Glu Trp 
65                  70                  75                  80  


Val Ser Leu Ser Lys Ala Arg Ile Val Glu Tyr Glu Lys Glu Met Glu 
                85                  90                  95      


Lys Met Lys Asn Leu Ile Pro Phe Asp Gln Met Thr Ile Glu Asp Leu 
            100                 105                 110         


Asn Glu Ala Phe Pro Glu Thr Lys Leu Asp Lys Lys Lys Tyr Pro Tyr 
        115                 120                 125             


Trp Pro His Gln Pro Ile Glu Asn Leu 
    130                 135         


<210>  939
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5J2__Homo_sapiens__NP_001003713

<400>  939

Met Ala Ser Val Val Pro Val Lys Asp Lys Lys Leu Leu Glu Val Lys 
1               5                   10                  15      


Leu Gly Glu Leu Pro Ser Trp Ile Leu Met Arg Asp Phe Ser Pro Ser 
            20                  25                  30          


Gly Ile Phe Gly Ala Phe Gln Arg Gly Tyr Tyr Arg Tyr Tyr Asn Lys 
        35                  40                  45              


Tyr Ile Asn Val Lys Lys Gly Ser Ile Ser Gly Ile Thr Met Val Leu 
    50                  55                  60                  


Ala Cys Tyr Val Leu Phe Ser Tyr Ser Phe Ser Tyr Lys His Leu Lys 
65                  70                  75                  80  


His Glu Arg Leu Arg Lys Tyr His 
                85              


<210>  940
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5J__Homo_sapiens__NP_001003696

<400>  940

Met Ile Leu Gln Arg Leu Phe Arg Phe Ser Ser Val Ile Arg Ser Ala 
1               5                   10                  15      


Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe 
            20                  25                  30          


Asn Lys Glu Leu Asp Pro Ile Gln Lys Leu Phe Val Asp Lys Ile Arg 
        35                  40                  45              


Glu Tyr Lys Ser Lys Arg Gln Thr Ser Gly Gly Pro Val Asp Ala Ser 
    50                  55                  60                  


Ser Glu Tyr Gln Gln Glu Leu Glu Arg Glu Leu Phe Lys Leu Lys Gln 
65                  70                  75                  80  


Met Phe Gly Asn Ala Asp Met Asn Thr Phe Pro Thr Phe Lys Phe Glu 
                85                  90                  95      


Asp Pro Lys Phe Glu Val Ile Glu Lys Pro Gln Ala 
            100                 105             


<210>  941
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5L__Homo_sapiens__NP_006467

<400>  941

Met Ala Gln Phe Val Arg Asn Leu Val Glu Lys Thr Pro Ala Leu Val 
1               5                   10                  15      


Asn Ala Ala Val Thr Tyr Ser Lys Pro Arg Leu Ala Thr Phe Trp Tyr 
            20                  25                  30          


Tyr Ala Lys Val Glu Leu Val Pro Pro Thr Pro Ala Glu Ile Pro Arg 
        35                  40                  45              


Ala Ile Gln Ser Leu Lys Lys Ile Val Asn Ser Ala Gln Thr Gly Ser 
    50                  55                  60                  


Phe Lys Gln Leu Thr Val Lys Glu Ala Val Leu Asn Gly Leu Val Ala 
65                  70                  75                  80  


Thr Glu Val Leu Met Trp Phe Tyr Val Gly Glu Ile Ile Gly Lys Arg 
                85                  90                  95      


Gly Ile Ile Gly Tyr Asp Val 
            100             


<210>  942
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP5O__Homo_sapiens__NP_001688

<400>  942

Met Ala Ala Pro Ala Val Ser Gly Leu Ser Arg Gln Val Arg Cys Phe 
1               5                   10                  15      


Ser Thr Ser Val Val Arg Pro Phe Ala Lys Leu Val Arg Pro Pro Val 
            20                  25                  30          


Gln Val Tyr Gly Ile Glu Gly Arg Tyr Ala Thr Ala Leu Tyr Ser Ala 
        35                  40                  45              


Ala Ser Lys Gln Asn Lys Leu Glu Gln Val Glu Lys Glu Leu Leu Arg 
    50                  55                  60                  


Val Ala Gln Ile Leu Lys Glu Pro Lys Val Ala Ala Ser Val Leu Asn 
65                  70                  75                  80  


Pro Tyr Val Lys Arg Ser Ile Lys Val Lys Ser Leu Asn Asp Ile Thr 
                85                  90                  95      


Ala Lys Glu Arg Phe Ser Pro Leu Thr Thr Asn Leu Ile Asn Leu Leu 
            100                 105                 110         


Ala Glu Asn Gly Arg Leu Ser Asn Thr Gln Gly Val Val Ser Ala Phe 
        115                 120                 125             


Ser Thr Met Met Ser Val His Arg Gly Glu Val Pro Cys Thr Val Thr 
    130                 135                 140                 


Ser Ala Ser Pro Leu Glu Glu Ala Thr Leu Ser Glu Leu Lys Thr Val 
145                 150                 155                 160 


Leu Lys Ser Phe Leu Ser Gln Gly Gln Val Leu Lys Leu Glu Ala Lys 
                165                 170                 175     


Thr Asp Pro Ser Ile Leu Gly Gly Met Ile Val Arg Ile Gly Glu Lys 
            180                 185                 190         


Tyr Val Asp Met Ser Val Lys Thr Lys Ile Gln Lys Leu Gly Arg Ala 
        195                 200                 205             


Met Arg Glu Ile Val 
    210             


<210>  943
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6AP1__Homo_sapiens__NP_001174

<400>  943

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Thr Leu 
    130                 135                 140                 


Thr Thr Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Thr Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Thr Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Thr Gly Asn Asp Glu Val Ile Gly Gln Val Leu Ser 
        195                 200                 205             


Thr Leu Lys Ser Glu Asp Val Pro Tyr Thr Ala Ala Leu Thr Ala Val 
    210                 215                 220                 


Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala Gly Gly Leu 
225                 230                 235                 240 


Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val Ile His Pro 
                245                 250                 255     


Pro Val Ser Tyr Asn Asp Thr Ala Pro Arg Ile Leu Phe Trp Ala Gln 
            260                 265                 270         


Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu Thr Pro Leu 
        275                 280                 285             


Thr Phe Gly Val Gln Glu Leu Asn Leu Thr Gly Ser Phe Trp Asn Asp 
    290                 295                 300                 


Ser Phe Ala Arg Leu Ser Leu Thr Tyr Glu Arg Leu Phe Gly Thr Thr 
305                 310                 315                 320 


Val Thr Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala 
                325                 330                 335     


Arg His Trp Phe Thr Met Glu Arg Leu Glu Val His Ser Asn Gly Ser 
            340                 345                 350         


Val Ala Tyr Phe Asn Ala Ser Gln Val Thr Gly Pro Ser Ile Tyr Ser 
        355                 360                 365             


Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly Ser Leu Leu 
    370                 375                 380                 


Val Ala Arg Thr Gln Pro Ser Pro Trp Gln Met Met Leu Gln Asp Phe 
385                 390                 395                 400 


Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser Tyr Ala Ser 
                405                 410                 415     


Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly Leu Leu Thr 
            420                 425                 430         


Ser Leu Phe Met Leu Phe Ile Phe Thr Tyr Gly Leu His Met Ile Leu 
        435                 440                 445             


Ser Leu Lys Thr Met Asp Arg Phe Asp Asp His Lys Gly Pro Thr Ile 
    450                 455                 460                 


Ser Leu Thr Gln Ile Val 
465                 470 


<210>  944
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6AP1L__Homo_sapiens__XP_011542025

<400>  944

Met Arg Leu Trp Lys Ala Arg Val Leu Lys Leu Val Leu Lys Thr Ala 
1               5                   10                  15      


Lys Asp Ser Arg Leu Gly Leu Asn Ser Lys Trp Leu Ser Leu Lys Leu 
            20                  25                  30          


Gly Asp Ala Gly Asn Pro Arg Ser Leu Ala Ile Arg Phe Ile Leu Thr 
        35                  40                  45              


Asn Tyr Asn Lys Leu Ser Ile Gln Ser Trp Phe Ser Leu Arg Arg Val 
    50                  55                  60                  


Glu Ile Ile Ser Asn Asn Ser Ile Gln Ala Val Phe Asn Pro Thr Gly 
65                  70                  75                  80  


Val Tyr Ala Pro Ser Gly Tyr Ser Tyr Arg Cys Gln Arg Val Gly Ser 
                85                  90                  95      


Leu Gln Gln Asp Gln Ala Leu Leu Leu Pro Ser Asp Thr Asp Asp Gly 
            100                 105                 110         


Ser Ser Leu Trp Glu Val Thr Phe Ile Asp Phe Gln Ile Gln Gly Phe 
        115                 120                 125             


Ala Ile Lys Gly Gly Arg Phe Thr Lys Ala Gln Asp Cys Ala Ser Ser 
    130                 135                 140                 


Phe Ser Pro Ala Phe Leu Ile Gly Leu Ala Met Ser Leu Ile Leu Leu 
145                 150                 155                 160 


Leu Val Leu Ala Tyr Ala Leu His Met Leu Ile Tyr Leu Arg Tyr Leu 
                165                 170                 175     


Asp Gln Gln Tyr Asp Leu Ile Ala Ser Pro Ala His Phe Ser Gln Leu 
            180                 185                 190         


Lys Ala Arg Asp Thr Ala Glu Glu Lys Glu Leu Leu Arg Ser Gln Gly 
        195                 200                 205             


Ala Glu Cys Tyr Lys Leu Arg Ser Gln Gln Ile Ser Lys Ile Tyr Val 
    210                 215                 220                 


<210>  945
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6AP2__Homo_sapiens__NP_005756

<400>  945

Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 
1               5                   10                  15      


Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 
            20                  25                  30          


Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 
        35                  40                  45              


Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 
    50                  55                  60                  


Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 
65                  70                  75                  80  


Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 
                85                  90                  95      


Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 
            100                 105                 110         


Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 
        115                 120                 125             


Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 
    130                 135                 140                 


Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 
145                 150                 155                 160 


Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 
                165                 170                 175     


Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 
            180                 185                 190         


Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 
        195                 200                 205             


Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 
    210                 215                 220                 


Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 
225                 230                 235                 240 


Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 
                245                 250                 255     


Gly Asn Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser 
            260                 265                 270         


Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn 
        275                 280                 285             


Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser 
    290                 295                 300                 


Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala 
305                 310                 315                 320 


Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp 
                325                 330                 335     


Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 
            340                 345                 350 


<210>  946
<211>  838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V0A1__Homo_sapiens__NP_001123492

<400>  946

Met Gly Glu Leu Phe Arg Ser Glu Glu Met Thr Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Thr Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Thr Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Thr Glu Leu 
        115                 120                 125             


Lys Phe Ile Leu Arg Lys Thr Gln Gln Phe Phe Asp Glu Ala Glu Leu 
    130                 135                 140                 


His His Gln Gln Met Ala Asp Pro Asp Leu Leu Glu Glu Ser Ser Ser 
145                 150                 155                 160 


Leu Leu Glu Pro Ser Glu Met Gly Arg Gly Thr Pro Leu Arg Leu Gly 
                165                 170                 175     


Phe Val Ala Gly Val Ile Asn Arg Glu Arg Ile Pro Thr Phe Glu Arg 
            180                 185                 190         


Met Leu Trp Arg Val Cys Arg Gly Asn Val Phe Leu Arg Gln Ala Glu 
        195                 200                 205             


Ile Glu Asn Pro Leu Glu Asp Pro Val Thr Gly Asp Tyr Val His Lys 
    210                 215                 220                 


Ser Val Phe Ile Ile Phe Phe Gln Gly Asp Gln Leu Lys Asn Arg Val 
225                 230                 235                 240 


Lys Lys Ile Cys Glu Gly Phe Arg Ala Ser Leu Tyr Pro Cys Pro Glu 
                245                 250                 255     


Thr Pro Gln Glu Arg Lys Glu Met Ala Ser Gly Val Asn Thr Arg Ile 
            260                 265                 270         


Asp Asp Leu Gln Met Val Leu Asn Gln Thr Glu Asp His Arg Gln Arg 
        275                 280                 285             


Val Leu Gln Ala Ala Ala Lys Asn Ile Arg Val Trp Phe Ile Lys Val 
    290                 295                 300                 


Arg Lys Met Lys Ala Ile Tyr His Thr Leu Asn Leu Cys Asn Ile Asp 
305                 310                 315                 320 


Val Thr Gln Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Val Thr Asp 
                325                 330                 335     


Leu Asp Ser Ile Gln Phe Ala Leu Arg Arg Gly Thr Glu His Ser Gly 
            340                 345                 350         


Ser Thr Val Pro Ser Ile Leu Asn Arg Met Gln Thr Asn Gln Thr Pro 
        355                 360                 365             


Pro Thr Tyr Asn Lys Thr Asn Lys Phe Thr Tyr Gly Phe Gln Asn Ile 
    370                 375                 380                 


Val Asp Ala Tyr Gly Ile Gly Thr Tyr Arg Glu Ile Asn Pro Ala Pro 
385                 390                 395                 400 


Tyr Thr Ile Ile Thr Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp 
                405                 410                 415     


Phe Gly His Gly Ile Leu Met Thr Leu Phe Ala Val Trp Met Val Leu 
            420                 425                 430         


Arg Glu Ser Arg Ile Leu Ser Gln Lys Asn Glu Asn Glu Met Phe Ser 
        435                 440                 445             


Thr Val Phe Ser Gly Arg Tyr Ile Ile Leu Leu Met Gly Val Phe Ser 
    450                 455                 460                 


Met Tyr Thr Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn 
465                 470                 475                 480 


Ile Phe Gly Ser Ser Trp Ser Val Arg Pro Met Phe Thr Tyr Asn Trp 
                485                 490                 495     


Thr Glu Glu Thr Leu Arg Gly Asn Pro Val Leu Gln Leu Asn Pro Ala 
            500                 505                 510         


Leu Pro Gly Val Phe Gly Gly Pro Tyr Pro Phe Gly Ile Asp Pro Ile 
        515                 520                 525             


Trp Asn Ile Ala Thr Asn Lys Leu Thr Phe Leu Asn Ser Phe Lys Met 
    530                 535                 540                 


Lys Met Ser Val Ile Leu Gly Ile Ile His Met Leu Phe Gly Val Ser 
545                 550                 555                 560 


Leu Ser Leu Phe Asn His Ile Tyr Phe Lys Lys Pro Leu Asn Ile Tyr 
                565                 570                 575     


Phe Gly Phe Ile Pro Glu Ile Ile Phe Met Thr Ser Leu Phe Gly Tyr 
            580                 585                 590         


Leu Val Ile Leu Ile Phe Tyr Lys Trp Thr Ala Tyr Asp Ala His Thr 
        595                 600                 605             


Ser Glu Asn Ala Pro Ser Leu Leu Ile His Phe Ile Asn Met Phe Leu 
    610                 615                 620                 


Phe Ser Tyr Pro Glu Ser Gly Tyr Ser Met Leu Tyr Ser Gly Gln Lys 
625                 630                 635                 640 


Gly Ile Gln Cys Phe Leu Val Val Val Ala Leu Leu Cys Val Pro Trp 
                645                 650                 655     


Met Leu Leu Phe Lys Pro Leu Val Leu Arg Arg Gln Tyr Leu Arg Arg 
            660                 665                 670         


Lys His Leu Gly Thr Leu Asn Phe Gly Gly Ile Arg Val Gly Asn Gly 
        675                 680                 685             


Pro Thr Glu Glu Asp Ala Glu Ile Ile Gln His Asp Gln Leu Ser Thr 
    690                 695                 700                 


His Ser Glu Asp Ala Asp Glu Phe Asp Phe Gly Asp Thr Met Val His 
705                 710                 715                 720 


Gln Ala Ile His Thr Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Thr 
                725                 730                 735     


Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu 
            740                 745                 750         


Ser Glu Val Leu Trp Thr Met Val Ile His Ile Gly Leu Ser Val Lys 
        755                 760                 765             


Ser Leu Ala Gly Gly Leu Val Leu Phe Phe Phe Phe Thr Ala Phe Ala 
    770                 775                 780                 


Thr Leu Thr Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe 
785                 790                 795                 800 


Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr 
                805                 810                 815     


Ser Gly Thr Gly Phe Lys Phe Leu Pro Phe Ser Phe Glu His Ile Arg 
            820                 825                 830         


Glu Gly Lys Phe Glu Glu 
        835             


<210>  947
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V0A2__Homo_sapiens__NP_036595

<400>  947

Met Gly Ser Leu Phe Arg Ser Glu Thr Met Cys Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Gly Thr Ala Tyr Glu Cys Leu Ser Ala Leu Gly Glu Lys 
            20                  25                  30          


Gly Leu Val Gln Phe Arg Asp Leu Asn Gln Asn Val Ser Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Gly Glu Val Lys Arg Cys Glu Glu Leu Glu Arg Ile 
    50                  55                  60                  


Leu Val Tyr Leu Val Gln Glu Ile Asn Arg Ala Asp Ile Pro Leu Pro 
65                  70                  75                  80  


Glu Gly Glu Ala Ser Pro Pro Ala Pro Pro Leu Lys Gln Val Leu Glu 
                85                  90                  95      


Met Gln Glu Gln Leu Gln Lys Leu Glu Val Glu Leu Arg Glu Val Thr 
            100                 105                 110         


Lys Asn Lys Glu Lys Leu Arg Lys Asn Leu Leu Glu Leu Ile Glu Tyr 
        115                 120                 125             


Thr His Met Leu Arg Val Thr Lys Thr Phe Val Lys Arg Asn Val Glu 
    130                 135                 140                 


Phe Glu Pro Thr Tyr Glu Glu Phe Pro Ser Leu Glu Ser Asp Ser Leu 
145                 150                 155                 160 


Leu Asp Tyr Ser Cys Met Gln Arg Leu Gly Ala Lys Leu Gly Phe Val 
                165                 170                 175     


Ser Gly Leu Ile Asn Gln Gly Lys Val Glu Ala Phe Glu Lys Met Leu 
            180                 185                 190         


Trp Arg Val Cys Lys Gly Tyr Thr Ile Val Ser Tyr Ala Glu Leu Asp 
        195                 200                 205             


Glu Ser Leu Glu Asp Pro Glu Thr Gly Glu Val Ile Lys Trp Tyr Val 
    210                 215                 220                 


Phe Leu Ile Ser Phe Trp Gly Glu Gln Ile Gly His Lys Val Lys Lys 
225                 230                 235                 240 


Ile Cys Asp Cys Tyr His Cys His Val Tyr Pro Tyr Pro Asn Thr Ala 
                245                 250                 255     


Glu Glu Arg Arg Glu Ile Gln Glu Gly Leu Asn Thr Arg Ile Gln Asp 
            260                 265                 270         


Leu Tyr Thr Val Leu His Lys Thr Glu Asp Tyr Leu Arg Gln Val Leu 
        275                 280                 285             


Cys Lys Ala Ala Glu Ser Val Tyr Ser Arg Val Ile Gln Val Lys Lys 
    290                 295                 300                 


Met Lys Ala Ile Tyr His Met Leu Asn Met Cys Ser Phe Asp Val Thr 
305                 310                 315                 320 


Asn Lys Cys Leu Ile Ala Glu Val Trp Cys Pro Glu Ala Asp Leu Gln 
                325                 330                 335     


Asp Leu Arg Arg Ala Leu Glu Glu Gly Ser Arg Glu Ser Gly Ala Thr 
            340                 345                 350         


Ile Pro Ser Phe Met Asn Ile Ile Pro Thr Lys Glu Thr Pro Pro Thr 
        355                 360                 365             


Arg Ile Arg Thr Asn Lys Phe Thr Glu Gly Phe Gln Asn Ile Val Asp 
    370                 375                 380                 


Ala Tyr Gly Val Gly Ser Tyr Arg Glu Val Asn Pro Ala Leu Phe Thr 
385                 390                 395                 400 


Ile Ile Thr Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly 
                405                 410                 415     


His Gly Phe Val Met Phe Leu Phe Ala Leu Leu Leu Val Leu Asn Glu 
            420                 425                 430         


Asn His Pro Arg Leu Asn Gln Ser Gln Glu Ile Met Arg Met Phe Phe 
        435                 440                 445             


Asn Gly Arg Tyr Ile Leu Leu Leu Met Gly Leu Phe Ser Val Tyr Thr 
    450                 455                 460                 


Gly Leu Ile Tyr Asn Asp Cys Phe Ser Lys Ser Val Asn Leu Phe Gly 
465                 470                 475                 480 


Ser Gly Trp Asn Val Ser Ala Met Tyr Ser Ser Ser His Pro Pro Ala 
                485                 490                 495     


Glu His Lys Lys Met Val Leu Trp Asn Asp Ser Val Val Arg His Asn 
            500                 505                 510         


Ser Ile Leu Gln Leu Asp Pro Ser Ile Pro Gly Val Phe Arg Gly Pro 
        515                 520                 525             


Tyr Pro Leu Gly Ile Asp Pro Ile Trp Asn Leu Ala Thr Asn Arg Leu 
    530                 535                 540                 


Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly Ile 
545                 550                 555                 560 


Ile His Met Thr Phe Gly Val Ile Leu Gly Ile Phe Asn His Leu His 
                565                 570                 575     


Phe Arg Lys Lys Phe Asn Ile Tyr Leu Val Ser Ile Pro Glu Leu Leu 
            580                 585                 590         


Phe Met Leu Cys Ile Phe Gly Tyr Leu Ile Phe Met Ile Phe Tyr Lys 
        595                 600                 605             


Trp Leu Val Phe Ser Ala Glu Thr Ser Arg Val Ala Pro Ser Ile Leu 
    610                 615                 620                 


Ile Glu Phe Ile Asn Met Phe Leu Phe Pro Ala Ser Lys Thr Ser Gly 
625                 630                 635                 640 


Leu Tyr Thr Gly Gln Glu Tyr Val Gln Arg Val Leu Leu Val Val Thr 
                645                 650                 655     


Ala Leu Ser Val Pro Val Leu Phe Leu Gly Lys Pro Leu Phe Leu Leu 
            660                 665                 670         


Trp Leu His Asn Gly Arg Ser Cys Phe Gly Val Asn Arg Ser Gly Tyr 
        675                 680                 685             


Thr Leu Ile Arg Lys Asp Ser Glu Glu Glu Val Ser Leu Leu Gly Ser 
    690                 695                 700                 


Gln Asp Ile Glu Glu Gly Asn His Gln Val Glu Asp Gly Cys Arg Glu 
705                 710                 715                 720 


Met Ala Cys Glu Glu Phe Asn Phe Gly Glu Ile Leu Met Thr Gln Val 
                725                 730                 735     


Ile His Ser Ile Glu Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser 
            740                 745                 750         


Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala Gln Leu Ser Asp 
        755                 760                 765             


Val Leu Trp Ala Met Leu Met Arg Val Gly Leu Arg Val Asp Thr Thr 
    770                 775                 780                 


Tyr Gly Val Leu Leu Leu Leu Pro Val Ile Ala Leu Phe Ala Val Leu 
785                 790                 795                 800 


Thr Ile Phe Ile Leu Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His 
                805                 810                 815     


Ala Ile Arg Leu His Trp Val Glu Phe Gln Asn Lys Phe Tyr Val Gly 
            820                 825                 830         


Ala Gly Thr Lys Phe Val Pro Phe Ser Phe Ser Leu Leu Ser Ser Lys 
        835                 840                 845             


Phe Asn Asn Asp Asp Ser Val Ala 
    850                 855     


<210>  948
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V0A4__Homo_sapiens__XP_005250451

<400>  948

Met Val Ser Val Phe Arg Ser Glu Glu Met Cys Leu Ser Gln Leu Phe 
1               5                   10                  15      


Leu Gln Val Glu Ala Ala Tyr Cys Cys Val Ala Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Leu Val Gln Phe Lys Asp Leu Asn Met Asn Val Asn Ser Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Ser Leu Glu Arg Ile 
    50                  55                  60                  


Leu Arg Phe Leu Glu Asp Glu Met Gln Asn Glu Ile Val Val Gln Leu 
65                  70                  75                  80  


Leu Glu Lys Ser Pro Leu Thr Pro Leu Pro Arg Glu Met Ile Thr Leu 
                85                  90                  95      


Glu Thr Val Leu Glu Lys Leu Glu Gly Glu Leu Gln Glu Ala Asn Gln 
            100                 105                 110         


Asn Gln Gln Ala Leu Lys Gln Ser Phe Leu Glu Leu Thr Glu Leu Lys 
        115                 120                 125             


Tyr Leu Leu Lys Lys Thr Gln Asp Phe Phe Glu Thr Glu Thr Asn Leu 
    130                 135                 140                 


Ala Asp Asp Phe Phe Thr Glu Asp Thr Ser Gly Leu Leu Glu Leu Lys 
145                 150                 155                 160 


Ala Val Pro Ala Tyr Met Thr Gly Lys Leu Gly Phe Ile Ala Gly Val 
                165                 170                 175     


Ile Asn Arg Glu Arg Met Ala Ser Phe Glu Arg Leu Leu Trp Arg Ile 
            180                 185                 190         


Cys Arg Gly Asn Val Tyr Leu Lys Phe Ser Glu Met Asp Ala Pro Leu 
        195                 200                 205             


Glu Asp Pro Val Thr Lys Glu Glu Ile Gln Lys Asn Ile Phe Ile Ile 
    210                 215                 220                 


Phe Tyr Gln Gly Glu Gln Leu Arg Gln Lys Ile Lys Lys Ile Cys Asp 
225                 230                 235                 240 


Gly Phe Arg Ala Thr Val Tyr Pro Cys Pro Glu Pro Ala Val Glu Arg 
                245                 250                 255     


Arg Glu Met Leu Glu Ser Val Asn Val Arg Leu Glu Asp Leu Ile Thr 
            260                 265                 270         


Val Ile Thr Gln Thr Glu Ser His Arg Gln Arg Leu Leu Gln Glu Ala 
        275                 280                 285             


Ala Ala Asn Trp His Ser Trp Leu Ile Lys Val Gln Lys Met Lys Ala 
    290                 295                 300                 


Val Tyr His Ile Leu Asn Met Cys Asn Ile Asp Val Thr Gln Gln Cys 
305                 310                 315                 320 


Val Ile Ala Glu Ile Trp Phe Pro Val Ala Asp Ala Thr Arg Ile Lys 
                325                 330                 335     


Arg Ala Leu Glu Gln Gly Met Glu Leu Ser Gly Ser Ser Met Ala Pro 
            340                 345                 350         


Ile Met Thr Thr Val Gln Ser Lys Thr Ala Pro Pro Thr Phe Asn Arg 
        355                 360                 365             


Thr Asn Lys Phe Thr Ala Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly 
    370                 375                 380                 


Val Gly Ser Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr 
385                 390                 395                 400 


Phe Pro Phe Leu Phe Ala Val Met Phe Gly Asp Cys Gly His Gly Thr 
                405                 410                 415     


Val Met Leu Leu Ala Ala Leu Trp Met Ile Leu Asn Glu Arg Arg Leu 
            420                 425                 430         


Leu Ser Gln Lys Thr Asp Asn Glu Ile Trp Asn Thr Phe Phe His Gly 
        435                 440                 445             


Arg Tyr Leu Ile Leu Leu Met Gly Ile Phe Ser Ile Tyr Thr Gly Leu 
    450                 455                 460                 


Ile Tyr Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser 
465                 470                 475                 480 


Trp Ser Val Gln Pro Met Phe Arg Asn Gly Thr Trp Asn Thr His Val 
                485                 490                 495     


Met Glu Glu Ser Leu Tyr Leu Gln Leu Asp Pro Ala Ile Pro Gly Val 
            500                 505                 510         


Tyr Phe Gly Asn Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Leu 
        515                 520                 525             


Ala Ser Asn Lys Leu Thr Phe Leu Asn Ser Tyr Lys Met Lys Met Ser 
    530                 535                 540                 


Val Ile Leu Gly Ile Val Gln Met Val Phe Gly Val Ile Leu Ser Leu 
545                 550                 555                 560 


Phe Asn His Ile Tyr Phe Arg Arg Thr Leu Asn Ile Ile Leu Gln Phe 
                565                 570                 575     


Ile Pro Glu Met Ile Phe Ile Leu Cys Leu Phe Gly Tyr Leu Val Phe 
            580                 585                 590         


Met Ile Ile Phe Lys Trp Cys Cys Phe Asp Val His Val Ser Gln His 
        595                 600                 605             


Ala Pro Ser Ile Leu Ile His Phe Ile Asn Met Phe Leu Phe Asn Tyr 
    610                 615                 620                 


Ser Asp Ser Ser Asn Ala Pro Leu Tyr Lys His Gln Gln Glu Val Gln 
625                 630                 635                 640 


Ser Phe Phe Val Val Met Ala Leu Ile Ser Val Pro Trp Met Leu Leu 
                645                 650                 655     


Ile Lys Pro Phe Ile Leu Arg Ala Ser His Arg Lys Ser Gln Leu Gln 
            660                 665                 670         


Ala Ser Arg Ile Gln Glu Asp Ala Thr Glu Asn Ile Glu Gly Asp Ser 
        675                 680                 685             


Ser Ser Pro Ser Ser Arg Ser Gly Gln Arg Thr Ser Ala Asp Thr His 
    690                 695                 700                 


Gly Ala Leu Asp Asp His Gly Glu Glu Phe Asn Phe Gly Asp Val Phe 
705                 710                 715                 720 


Val His Gln Ala Ile His Thr Ile Glu Tyr Cys Leu Gly Cys Ile Ser 
                725                 730                 735     


Asn Thr Ala Ser Tyr Leu Arg Leu Trp Ala Leu Ser Leu Ala His Ala 
            740                 745                 750         


Gln Leu Ser Glu Val Leu Trp Thr Met Val Met Asn Ser Gly Leu Gln 
        755                 760                 765             


Thr Arg Gly Trp Gly Gly Ile Val Gly Val Phe Ile Ile Phe Ala Val 
    770                 775                 780                 


Phe Ala Val Leu Thr Val Ala Ile Leu Leu Ile Met Glu Gly Leu Ser 
785                 790                 795                 800 


Ala Phe Leu His Ala Leu Arg Leu His Trp Val Glu Phe Gln Asn Lys 
                805                 810                 815     


Phe Tyr Val Gly Asp Gly Tyr Lys Phe Ser Pro Phe Ser Phe Lys His 
            820                 825                 830         


Ile Leu Asp Gly Thr Ala Glu Glu 
        835                 840 


<210>  949
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V0C__Homo_sapiens__NP_001185498

<400>  949

Met Ser Glu Ser Lys Ser Gly Pro Glu Tyr Ala Ser Phe Phe Ala Val 
1               5                   10                  15      


Met Gly Ala Ser Ala Ala Met Val Phe Ser Ala Leu Gly Ala Ala Tyr 
            20                  25                  30          


Gly Thr Ala Lys Ser Gly Thr Gly Ile Ala Ala Met Ser Val Met Arg 
        35                  40                  45              


Pro Glu Gln Ile Met Lys Ser Ile Ile Pro Val Val Met Ala Gly Ile 
    50                  55                  60                  


Ile Ala Ile Tyr Gly Leu Val Val Ala Val Leu Ile Ala Asn Ser Leu 
65                  70                  75                  80  


Asn Asp Asp Ile Ser Leu Tyr Lys Ser Phe Leu Gln Leu Gly Ala Gly 
                85                  90                  95      


Leu Ser Val Gly Leu Ser Gly Leu Ala Ala Gly Phe Ala Ile Gly Ile 
            100                 105                 110         


Val Gly Asp Ala Gly Val Arg Gly Thr Ala Gln Gln Pro Arg Leu Phe 
        115                 120                 125             


Val Gly Met Ile Leu Ile Leu Ile Phe Ala Glu Val Leu Gly Leu Tyr 
    130                 135                 140                 


Gly Leu Ile Val Ala Leu Ile Leu Ser Thr Lys 
145                 150                 155 


<210>  950
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V0D1__Homo_sapiens__NP_004682

<400>  950

Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Thr Leu Glu Asp Leu Lys Leu His 
        35                  40                  45              


Leu Gln Ser Thr Asp Tyr Gly Asn Phe Leu Ala Asn Glu Ala Ser Pro 
    50                  55                  60                  


Leu Thr Val Ser Val Ile Asp Asp Arg Leu Lys Glu Lys Met Val Val 
65                  70                  75                  80  


Glu Phe Arg His Met Arg Asn His Ala Tyr Glu Pro Leu Ala Ser Phe 
                85                  90                  95      


Leu Asp Phe Ile Thr Tyr Ser Tyr Met Ile Asp Asn Val Ile Leu Leu 
            100                 105                 110         


Ile Thr Gly Thr Leu His Gln Arg Ser Ile Ala Glu Leu Val Pro Lys 
        115                 120                 125             


Cys His Pro Leu Gly Ser Phe Glu Gln Met Glu Ala Val Asn Ile Ala 
    130                 135                 140                 


Gln Thr Pro Ala Glu Leu Tyr Asn Ala Ile Leu Val Asp Thr Pro Leu 
145                 150                 155                 160 


Ala Ala Phe Phe Gln Asp Cys Ile Ser Glu Gln Asp Leu Asp Glu Met 
                165                 170                 175     


Asn Ile Glu Ile Ile Arg Asn Thr Leu Tyr Lys Ala Tyr Leu Glu Ser 
            180                 185                 190         


Phe Tyr Lys Phe Cys Thr Leu Leu Gly Gly Thr Thr Ala Asp Ala Met 
        195                 200                 205             


Cys Pro Ile Leu Glu Phe Glu Ala Asp Arg Arg Ala Phe Ile Ile Thr 
    210                 215                 220                 


Ile Asn Ser Phe Gly Thr Glu Leu Ser Lys Glu Asp Arg Ala Lys Leu 
225                 230                 235                 240 


Phe Pro His Cys Gly Arg Leu Tyr Pro Glu Gly Leu Ala Gln Leu Ala 
                245                 250                 255     


Arg Ala Asp Asp Tyr Glu Gln Val Lys Asn Val Ala Asp Tyr Tyr Pro 
            260                 265                 270         


Glu Tyr Lys Leu Leu Phe Glu Gly Ala Gly Ser Asn Pro Gly Asp Lys 
        275                 280                 285             


Thr Leu Glu Asp Arg Phe Phe Glu His Glu Val Lys Leu Asn Lys Leu 
    290                 295                 300                 


Ala Phe Leu Asn Gln Phe His Phe Gly Val Phe Tyr Ala Phe Val Lys 
305                 310                 315                 320 


Leu Lys Glu Gln Glu Cys Arg Asn Ile Val Trp Ile Ala Glu Cys Ile 
                325                 330                 335     


Ala Gln Arg His Arg Ala Lys Ile Asp Asn Tyr Ile Pro Ile Phe 
            340                 345                 350     


<210>  951
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V0E1__Homo_sapiens__NP_003936

<400>  951

Met Ala Tyr His Gly Leu Thr Val Pro Leu Ile Val Met Ser Val Phe 
1               5                   10                  15      


Trp Gly Phe Val Gly Phe Leu Val Pro Trp Phe Ile Pro Lys Gly Pro 
            20                  25                  30          


Asn Arg Gly Val Ile Ile Thr Met Leu Val Thr Cys Ser Val Cys Cys 
        35                  40                  45              


Tyr Leu Phe Trp Leu Ile Ala Ile Leu Ala Gln Leu Asn Pro Leu Phe 
    50                  55                  60                  


Gly Pro Gln Leu Lys Asn Glu Thr Ile Trp Tyr Leu Lys Tyr His Trp 
65                  70                  75                  80  


Pro 
    


<210>  952
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V0E2__Homo_sapiens__NP_001094062

<400>  952

Met Arg Val Arg Gly Pro Ala Arg Leu Ile Ala Ser Gly Ala Arg Leu 
1               5                   10                  15      


Leu Leu Arg Met Leu Ser Ala Leu Pro Gly Trp Gly Pro Ala His Leu 
            20                  25                  30          


Gln Arg Pro Leu Leu Gly Pro Ala Ser Cys Leu Gly Ile Leu Arg Pro 
        35                  40                  45              


Ala Met Thr Ala His Ser Phe Ala Leu Pro Val Ile Ile Phe Thr Thr 
    50                  55                  60                  


Phe Trp Gly Leu Val Gly Ile Ala Gly Pro Trp Phe Val Pro Lys Gly 
65                  70                  75                  80  


Pro Asn Arg Gly Val Ile Ile Thr Met Leu Val Ala Thr Ala Val Cys 
                85                  90                  95      


Cys Tyr Leu Leu Cys Pro Ala Leu Gly Met Thr Val Ala Pro Leu Ser 
            100                 105                 110         


Leu Thr Thr Pro Ser Ser Gly Pro Ser Pro Thr Gln Leu Cys Leu Val 
        115                 120                 125             


Thr Ser Ser Leu Leu Leu Ala Pro Arg Asp Pro Asp Pro Gln Gly Leu 
    130                 135                 140                 


Pro Gly Ser Trp Lys Ser Ser Gln Ser Ser Gln Pro Ala Arg Ala Leu 
145                 150                 155                 160 


Gly Ser Pro Gly His Ser Ser Gly Arg Gly Asp Val Leu Leu Gln Tyr 
                165                 170                 175     


Pro His Cys Ser Gly Val Cys Pro Leu Ser Gln Gly Asp Ala Ala Gly 
            180                 185                 190         


Glu Leu Val Trp Val Gly Ser Phe Pro Leu Gln Thr Gly Gln Met Pro 
        195                 200                 205             


Gly Leu Ser Pro Ser 
    210             


<210>  953
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1B1__Homo_sapiens__NP_001683

<400>  953

Met Ala Met Glu Ile Asp Ser Arg Pro Gly Gly Leu Pro Gly Ser Ser 
1               5                   10                  15      


Cys Asn Leu Gly Ala Ala Arg Glu His Met Gln Ala Val Thr Arg Asn 
            20                  25                  30          


Tyr Ile Thr His Pro Arg Val Thr Tyr Arg Thr Val Cys Ser Val Asn 
        35                  40                  45              


Gly Pro Leu Val Val Leu Asp Arg Val Lys Phe Ala Gln Tyr Ala Glu 
    50                  55                  60                  


Ile Val His Phe Thr Leu Pro Asp Gly Thr Gln Arg Ser Gly Gln Val 
65                  70                  75                  80  


Leu Glu Val Ala Gly Thr Lys Ala Ile Val Gln Val Phe Glu Gly Thr 
                85                  90                  95      


Ser Gly Ile Asp Ala Arg Lys Thr Thr Cys Glu Phe Thr Gly Asp Ile 
            100                 105                 110         


Leu Arg Thr Pro Val Ser Glu Asp Met Leu Gly Arg Val Phe Asn Gly 
        115                 120                 125             


Ser Gly Lys Pro Ile Asp Lys Gly Pro Val Val Met Ala Glu Asp Phe 
    130                 135                 140                 


Leu Asp Ile Asn Gly Gln Pro Ile Asn Pro His Ser Arg Ile Tyr Pro 
145                 150                 155                 160 


Glu Glu Met Ile Gln Thr Gly Ile Ser Pro Ile Asp Val Met Asn Ser 
                165                 170                 175     


Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe Ser Ala Ala Gly Leu Pro 
            180                 185                 190         


His Asn Glu Ile Ala Ala Gln Ile Cys Arg Gln Ala Gly Leu Val Lys 
        195                 200                 205             


Lys Ser Lys Ala Val Leu Asp Tyr His Asp Asp Asn Phe Ala Ile Val 
    210                 215                 220                 


Phe Ala Ala Met Gly Val Asn Met Glu Thr Ala Arg Phe Phe Lys Ser 
225                 230                 235                 240 


Asp Phe Glu Gln Asn Gly Thr Met Gly Asn Val Cys Leu Phe Leu Asn 
                245                 250                 255     


Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile Ile Thr Pro Arg Leu Ala 
            260                 265                 270         


Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln Cys Glu Lys His Val Leu 
        275                 280                 285             


Val Ile Leu Thr Asp Met Ser Ser Tyr Ala Glu Ala Leu Arg Glu Val 
    290                 295                 300                 


Ser Ala Ala Arg Glu Glu Val Pro Gly Arg Arg Gly Phe Pro Gly Tyr 
305                 310                 315                 320 


Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu Arg Ala Gly Arg Val Glu 
                325                 330                 335     


Gly Arg Gly Gly Ser Ile Thr Gln Ile Pro Ile Leu Thr Met Pro Asn 
            340                 345                 350         


Asp Asp Ile Thr His Pro Ile Pro Asp Leu Thr Gly Phe Ile Thr Glu 
        355                 360                 365             


Gly Gln Ile Tyr Val Asp Arg Gln Leu His Asn Arg Gln Ile Tyr Pro 
    370                 375                 380                 


Pro Ile Asn Val Leu Pro Ser Leu Ser Arg Leu Met Lys Ser Ala Ile 
385                 390                 395                 400 


Gly Glu Gly Met Thr Arg Lys Asp His Gly Asp Val Ser Asn Gln Leu 
                405                 410                 415     


Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val Gln Ala Met Lys Ala Val 
            420                 425                 430         


Val Gly Glu Glu Ala Leu Thr Ser Glu Asp Leu Leu Tyr Leu Glu Phe 
        435                 440                 445             


Leu Gln Lys Phe Glu Lys Asn Phe Ile Asn Gln Gly Pro Tyr Glu Asn 
    450                 455                 460                 


Arg Ser Val Phe Glu Ser Leu Asp Leu Gly Trp Lys Leu Leu Arg Ile 
465                 470                 475                 480 


Phe Pro Lys Glu Met Leu Lys Arg Ile Pro Gln Ala Val Ile Asp Glu 
                485                 490                 495     


Phe Tyr Ser Arg Glu Gly Ala Leu Gln Asp Leu Ala Pro Asp Thr Ala 
            500                 505                 510         


Leu 
    


<210>  954
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1B2__Homo_sapiens__NP_001684

<400>  954

Met Ala Leu Arg Ala Met Arg Gly Ile Val Asn Gly Ala Ala Pro Glu 
1               5                   10                  15      


Leu Pro Val Pro Thr Gly Gly Pro Ala Val Gly Ala Arg Glu Gln Ala 
            20                  25                  30          


Leu Ala Val Ser Arg Asn Tyr Leu Ser Gln Pro Arg Leu Thr Tyr Lys 
        35                  40                  45              


Thr Val Ser Gly Val Asn Gly Pro Leu Val Ile Leu Asp His Val Lys 
    50                  55                  60                  


Phe Pro Arg Tyr Ala Glu Ile Val His Leu Thr Leu Pro Asp Gly Thr 
65                  70                  75                  80  


Lys Arg Ser Gly Gln Val Leu Glu Val Ser Gly Ser Lys Ala Val Val 
                85                  90                  95      


Gln Val Phe Glu Gly Thr Ser Gly Ile Asp Ala Lys Lys Thr Ser Cys 
            100                 105                 110         


Glu Phe Thr Gly Asp Ile Leu Arg Thr Pro Val Ser Glu Asp Met Leu 
        115                 120                 125             


Gly Arg Val Phe Asn Gly Ser Gly Lys Pro Ile Asp Arg Gly Pro Val 
    130                 135                 140                 


Val Leu Ala Glu Asp Phe Leu Asp Ile Met Gly Gln Pro Ile Asn Pro 
145                 150                 155                 160 


Gln Cys Arg Ile Tyr Pro Glu Glu Met Ile Gln Thr Gly Ile Ser Ala 
                165                 170                 175     


Ile Asp Gly Met Asn Ser Ile Ala Arg Gly Gln Lys Ile Pro Ile Phe 
            180                 185                 190         


Ser Ala Ala Gly Leu Pro His Asn Glu Ile Ala Ala Gln Ile Cys Arg 
        195                 200                 205             


Gln Ala Gly Leu Val Lys Lys Ser Lys Asp Val Val Asp Tyr Ser Glu 
    210                 215                 220                 


Glu Asn Phe Ala Ile Val Phe Ala Ala Met Gly Val Asn Met Glu Thr 
225                 230                 235                 240 


Ala Arg Phe Phe Lys Ser Asp Phe Glu Glu Asn Gly Ser Met Asp Asn 
                245                 250                 255     


Val Cys Leu Phe Leu Asn Leu Ala Asn Asp Pro Thr Ile Glu Arg Ile 
            260                 265                 270         


Ile Thr Pro Arg Leu Ala Leu Thr Thr Ala Glu Phe Leu Ala Tyr Gln 
        275                 280                 285             


Cys Glu Lys His Val Leu Val Ile Leu Thr Asp Met Ser Ser Tyr Ala 
    290                 295                 300                 


Glu Ala Leu Arg Glu Val Ser Ala Ala Arg Glu Glu Val Pro Gly Arg 
305                 310                 315                 320 


Arg Gly Phe Pro Gly Tyr Met Tyr Thr Asp Leu Ala Thr Ile Tyr Glu 
                325                 330                 335     


Arg Ala Gly Arg Val Glu Gly Arg Asn Gly Ser Ile Thr Gln Ile Pro 
            340                 345                 350         


Ile Leu Thr Met Pro Asn Asp Asp Ile Thr His Pro Ile Pro Asp Leu 
        355                 360                 365             


Thr Gly Tyr Ile Thr Glu Gly Gln Ile Tyr Val Asp Arg Gln Leu His 
    370                 375                 380                 


Asn Arg Gln Ile Tyr Pro Pro Ile Asn Val Leu Pro Ser Leu Ser Arg 
385                 390                 395                 400 


Leu Met Lys Ser Ala Ile Gly Glu Gly Met Thr Arg Lys Asp His Ala 
                405                 410                 415     


Asp Val Ser Asn Gln Leu Tyr Ala Cys Tyr Ala Ile Gly Lys Asp Val 
            420                 425                 430         


Gln Ala Met Lys Ala Val Val Gly Glu Glu Ala Leu Thr Ser Asp Asp 
        435                 440                 445             


Leu Leu Tyr Leu Glu Phe Leu Gln Lys Phe Glu Arg Asn Phe Ile Ala 
    450                 455                 460                 


Gln Gly Pro Tyr Glu Asn Arg Thr Val Phe Glu Thr Leu Asp Ile Gly 
465                 470                 475                 480 


Trp Gln Leu Leu Arg Ile Phe Pro Lys Glu Met Leu Lys Arg Ile Pro 
                485                 490                 495     


Gln Ser Thr Leu Ser Glu Phe Tyr Pro Arg Asp Ser Ala Lys His 
            500                 505                 510     


<210>  955
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1C1__Homo_sapiens__NP_001686

<400>  955

Met Thr Glu Phe Trp Leu Ile Ser Ala Pro Gly Glu Lys Thr Cys Gln 
1               5                   10                  15      


Gln Thr Trp Glu Lys Leu His Ala Ala Thr Ser Lys Asn Asn Asn Leu 
            20                  25                  30          


Ala Val Thr Ser Lys Phe Asn Ile Pro Asp Leu Lys Val Gly Thr Leu 
        35                  40                  45              


Asp Val Leu Val Gly Leu Ser Asp Glu Leu Ala Lys Leu Asp Ala Phe 
    50                  55                  60                  


Val Glu Gly Val Val Lys Lys Val Ala Gln Tyr Met Ala Asp Val Leu 
65                  70                  75                  80  


Glu Asp Ser Lys Asp Lys Val Gln Glu Asn Leu Leu Ala Asn Gly Val 
                85                  90                  95      


Asp Leu Val Thr Tyr Ile Thr Arg Phe Gln Trp Asp Met Ala Lys Tyr 
            100                 105                 110         


Pro Ile Lys Gln Ser Leu Lys Asn Ile Ser Glu Ile Ile Ala Lys Gly 
        115                 120                 125             


Val Thr Gln Ile Asp Asn Asp Leu Lys Ser Arg Ala Ser Ala Tyr Asn 
    130                 135                 140                 


Asn Leu Lys Gly Asn Leu Gln Asn Leu Glu Arg Lys Asn Ala Gly Ser 
145                 150                 155                 160 


Leu Leu Thr Arg Ser Leu Ala Glu Ile Val Lys Lys Asp Asp Phe Val 
                165                 170                 175     


Leu Asp Ser Glu Tyr Leu Val Thr Leu Leu Val Val Val Pro Lys Leu 
            180                 185                 190         


Asn His Asn Asp Trp Ile Lys Gln Tyr Glu Thr Leu Ala Glu Met Val 
        195                 200                 205             


Val Pro Arg Ser Ser Asn Val Leu Ser Glu Asp Gln Asp Ser Tyr Leu 
    210                 215                 220                 


Cys Asn Val Thr Leu Phe Arg Lys Ala Val Asp Asp Phe Arg His Lys 
225                 230                 235                 240 


Ala Arg Glu Asn Lys Phe Ile Val Arg Asp Phe Gln Tyr Asn Glu Glu 
                245                 250                 255     


Glu Met Lys Ala Asp Lys Glu Glu Met Asn Arg Leu Ser Thr Asp Lys 
            260                 265                 270         


Lys Lys Gln Phe Gly Pro Leu Val Arg Trp Leu Lys Val Asn Phe Ser 
        275                 280                 285             


Glu Ala Phe Ile Ala Trp Ile His Val Lys Ala Leu Arg Val Phe Val 
    290                 295                 300                 


Glu Ser Val Leu Arg Tyr Gly Leu Pro Val Asn Phe Gln Ala Met Leu 
305                 310                 315                 320 


Leu Gln Pro Asn Lys Lys Thr Leu Lys Lys Leu Arg Glu Val Leu His 
                325                 330                 335     


Glu Leu Tyr Lys His Leu Asp Ser Ser Ala Ala Ala Ile Ile Asp Ala 
            340                 345                 350         


Pro Met Asp Ile Pro Gly Leu Asn Leu Ser Gln Gln Glu Tyr Tyr Pro 
        355                 360                 365             


Tyr Val Tyr Tyr Lys Ile Asp Cys Asn Leu Leu Glu Phe Lys 
    370                 375                 380         


<210>  956
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1D__Homo_sapiens__NP_057078

<400>  956

Met Ser Gly Lys Asp Arg Ile Glu Ile Phe Pro Ser Arg Met Ala Gln 
1               5                   10                  15      


Thr Ile Met Lys Ala Arg Leu Lys Gly Ala Gln Thr Gly Arg Asn Leu 
            20                  25                  30          


Leu Lys Lys Lys Ser Asp Ala Leu Thr Leu Arg Phe Arg Gln Ile Leu 
        35                  40                  45              


Lys Lys Ile Ile Glu Thr Lys Met Leu Met Gly Glu Val Met Arg Glu 
    50                  55                  60                  


Ala Ala Phe Ser Leu Ala Glu Ala Lys Phe Thr Ala Gly Asp Phe Ser 
65                  70                  75                  80  


Thr Thr Val Ile Gln Asn Val Asn Lys Ala Gln Val Lys Ile Arg Ala 
                85                  90                  95      


Lys Lys Asp Asn Val Ala Gly Val Thr Leu Pro Val Phe Glu His Tyr 
            100                 105                 110         


His Glu Gly Thr Asp Ser Tyr Glu Leu Thr Gly Leu Ala Arg Gly Gly 
        115                 120                 125             


Glu Gln Leu Ala Lys Leu Lys Arg Asn Tyr Ala Lys Ala Val Glu Leu 
    130                 135                 140                 


Leu Val Glu Leu Ala Ser Leu Gln Thr Ser Phe Val Thr Leu Asp Glu 
145                 150                 155                 160 


Ala Ile Lys Ile Thr Asn Arg Arg Val Asn Ala Ile Glu His Val Ile 
                165                 170                 175     


Ile Pro Arg Ile Glu Arg Thr Leu Ala Tyr Ile Ile Thr Glu Leu Asp 
            180                 185                 190         


Glu Arg Glu Arg Glu Glu Phe Tyr Arg Leu Lys Lys Ile Gln Glu Lys 
        195                 200                 205             


Lys Lys Ile Leu Lys Glu Lys Ser Glu Lys Asp Leu Glu Gln Arg Arg 
    210                 215                 220                 


Ala Ala Gly Glu Val Leu Glu Pro Ala Asn Leu Leu Ala Glu Glu Lys 
225                 230                 235                 240 


Asp Glu Asp Leu Leu Phe Glu 
                245         


<210>  957
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1E1__Homo_sapiens__NP_001034455

<400>  957

Met Ala Leu Ser Asp Ala Asp Val Gln Lys Gln Ala Glu Glu Glu Phe 
1               5                   10                  15      


Asn Ile Glu Lys Gly Arg Leu Val Gln Thr Gln Arg Leu Lys Ile Met 
            20                  25                  30          


Glu Tyr Tyr Glu Lys Lys Glu Lys Gln Ile Glu Gln Gln Lys Lys Ile 
        35                  40                  45              


Gln Met Ser Asn Leu Met Asn Gln Ala Arg Leu Lys Val Leu Arg Ala 
    50                  55                  60                  


Arg Asp Asp Leu Ile Thr Asp Leu Leu Asn Glu Ala Lys Gln Arg Leu 
65                  70                  75                  80  


Ser Lys Val Val Lys Asp Thr Thr Arg Tyr Gln Val Leu Leu Asp Gly 
                85                  90                  95      


Leu Val Leu Gln Gly Leu Tyr Gln Leu Leu Glu Pro Arg Met Ile Val 
            100                 105                 110         


Arg Cys Arg Lys Gln Asp Phe Pro Leu Val Lys Ala Ala Val Gln Lys 
        115                 120                 125             


Ala Ile Pro Met Tyr Lys Ile Ala Thr Lys Asn Asp Val Asp Val Gln 
    130                 135                 140                 


Ile Asp Gln Glu Ser Tyr Leu Pro Glu Asp Ile Ala Gly Gly Val Glu 
145                 150                 155                 160 


Ile Tyr Asn Gly Asp Arg Lys Ile Lys Val Ser Asn Thr Leu Glu Ser 
                165                 170                 175     


Arg Leu Asp Leu Ile Ala Gln Gln Met Met Pro Glu Val Arg Gly Ala 
            180                 185                 190         


Leu Phe Gly Ala Asn Ala Asn Arg Lys Phe Leu Asp 
        195                 200                 


<210>  958
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1F__Homo_sapiens__NP_001185838

<400>  958

Met Ala Gly Arg Gly Lys Leu Ile Ala Val Ile Gly Asp Glu Asp Thr 
1               5                   10                  15      


Val Thr Gly Phe Leu Leu Gly Gly Ile Gly Glu Leu Asn Lys Asn Arg 
            20                  25                  30          


His Pro Asn Phe Leu Val Val Glu Lys Asp Thr Thr Ile Asn Glu Ile 
        35                  40                  45              


Glu Asp Thr Phe Arg Ser Leu Gly Ser Leu Pro Gly Ser Val Val Glu 
    50                  55                  60                  


Ala Asn Pro Asn Gln Arg Asp Pro Pro Leu Trp Asp Glu Ile Asp Ser 
65                  70                  75                  80  


Arg Gln Phe Leu Asn Arg Asp Asp Ile Gly Ile Ile Leu Ile Asn Gln 
                85                  90                  95      


Tyr Ile Ala Glu Met Val Arg His Ala Leu Asp Ala His Gln Gln Ser 
            100                 105                 110         


Ile Pro Ala Val Leu Glu Ile Pro Ser Lys Glu His Pro Tyr Asp Ala 
        115                 120                 125             


Ala Lys Asp Ser Ile Leu Arg Arg Ala Arg Gly Met Phe Thr Ala Glu 
    130                 135                 140                 


Asp Leu Arg 
145         


<210>  959
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1G1__Homo_sapiens__NP_004879

<400>  959

Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ser Glu Ala Arg Lys Arg Lys Asn Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Gln Ala Glu Ile Glu Gln Tyr Arg 
        35                  40                  45              


Leu Gln Arg Glu Lys Glu Phe Lys Ala Lys Glu Ala Ala Ala Leu Gly 
    50                  55                  60                  


Ser Arg Gly Ser Cys Ser Thr Glu Val Glu Lys Glu Thr Gln Glu Lys 
65                  70                  75                  80  


Met Thr Ile Leu Gln Thr Tyr Phe Arg Gln Asn Arg Asp Glu Val Leu 
                85                  90                  95      


Asp Asn Leu Leu Ala Phe Val Cys Asp Ile Arg Pro Glu Ile His Glu 
            100                 105                 110         


Asn Tyr Arg Ile Asn Gly 
        115             


<210>  960
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1G2__Homo_sapiens__NP_001191007

<400>  960

Met Ala Ser Gln Ser Gln Gly Ile Gln Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Ala Glu Lys Val Ala Asp Ala Arg Lys Arg Lys Ala Arg Arg 
            20                  25                  30          


Leu Lys Gln Ala Thr Arg Arg Gln Val Gln Gly Met Gln Ser Ser Gln 
        35                  40                  45              


Gln Arg Asn Arg Glu Arg Val Leu Ala Gln Leu Leu Gly Met Val Cys 
    50                  55                  60                  


Asp Val Arg Pro Gln Val His Pro Asn Tyr Arg Ile Ser Ala 
65                  70                  75              


<210>  961
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP6V1G3__Homo_sapiens__XP_006725021

<400>  961

Met Thr Ser Gln Ser Gln Gly Ile His Gln Leu Leu Gln Ala Glu Lys 
1               5                   10                  15      


Arg Ala Lys Asp Lys Leu Glu Glu Ala Lys Lys Arg Lys Gly Lys Arg 
            20                  25                  30          


Leu Lys Gln Ala Lys Glu Glu Ala Met Val Glu Ile Asp Gln Tyr Arg 
        35                  40                  45              


Met Gln Arg Asp Lys Glu Phe Arg Leu Lys Gln Ser Lys Ile Met Gly 
    50                  55                  60                  


Ser Gln Asn Asn Leu Ser Asp Glu Ile Glu Glu Gln Thr Leu Gly Lys 
65                  70                  75                  80  


Ile Gln Glu Leu Asn Gly His Tyr Asn Lys Tyr Met Glu Ser Val Met 
                85                  90                  95      


Asn Gln Leu Leu Ser Met Val Cys Asp Met Lys Pro Glu Ile His Val 
            100                 105                 110         


Asn Tyr Arg Ala Thr Asn 
        115             


<210>  962
<211>  1500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP7A__Homo_sapiens__NP_000043

<400>  962

Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly 
1               5                   10                  15      


Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys 
            20                  25                  30          


Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala 
        35                  40                  45              


Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu 
    50                  55                  60                  


Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro 
65                  70                  75                  80  


Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu 
                85                  90                  95      


Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly 
            100                 105                 110         


Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr 
        115                 120                 125             


Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro 
    130                 135                 140                 


Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys 
145                 150                 155                 160 


Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys 
                165                 170                 175     


Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys 
            180                 185                 190         


Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn 
        195                 200                 205             


Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu 
    210                 215                 220                 


Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys 
225                 230                 235                 240 


Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys 
                245                 250                 255     


Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser 
            260                 265                 270         


Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys 
        275                 280                 285             


Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr 
    290                 295                 300                 


Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys 
305                 310                 315                 320 


Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu 
                325                 330                 335     


Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu 
            340                 345                 350         


Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu 
        355                 360                 365             


Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp 
    370                 375                 380                 


Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser 
385                 390                 395                 400 


Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn 
                405                 410                 415     


Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg 
            420                 425                 430         


Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn 
        435                 440                 445             


Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu 
    450                 455                 460                 


Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp 
465                 470                 475                 480 


Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg 
            500                 505                 510         


Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu 
    530                 535                 540                 


Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp 
545                 550                 555                 560 


Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile 
            580                 585                 590         


Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser 
    610                 615                 620                 


Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His 
625                 630                 635                 640 


Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val 
                645                 650                 655     


Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met 
            660                 665                 670         


Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser 
        675                 680                 685             


Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln 
    690                 695                 700                 


Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys 
705                 710                 715                 720 


Val Pro Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala Tyr 
                725                 730                 735     


Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu 
            740                 745                 750         


Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val Ala 
        755                 760                 765             


Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr Pro 
    770                 775                 780                 


Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Ile 
785                 790                 795                 800 


Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln 
                805                 810                 815     


Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu 
            820                 825                 830         


Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile 
        835                 840                 845             


Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu 
    850                 855                 860                 


Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro 
865                 870                 875                 880 


Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln 
                885                 890                 895     


Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr Thr 
            900                 905                 910         


Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala 
        915                 920                 925             


Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe 
    930                 935                 940                 


Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile Gly 
945                 950                 955                 960 


Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg 
                965                 970                 975     


Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser 
            980                 985                 990         


Ile Thr Val Leu Cys Ile Ala Cys  Pro Cys Ser Leu Gly  Leu Ala Thr 
        995                 1000                 1005             


Pro Thr  Ala Val Met Val Gly  Thr Gly Val Gly Ala  Gln Asn Gly 
    1010                 1015                 1020             


Ile Leu  Ile Lys Gly Gly Glu  Pro Leu Glu Met Ala  His Lys Val 
    1025                 1030                 1035             


Lys Val  Val Val Phe Asp Lys  Thr Gly Thr Ile Thr  His Gly Thr 
    1040                 1045                 1050             


Pro Val  Val Asn Gln Val Lys  Val Leu Thr Glu Ser  Asn Arg Ile 
    1055                 1060                 1065             


Ser His  His Lys Ile Leu Ala  Ile Val Gly Thr Ala  Glu Ser Asn 
    1070                 1075                 1080             


Ser Glu  His Pro Leu Gly Thr  Ala Ile Thr Lys Tyr  Cys Lys Gln 
    1085                 1090                 1095             


Glu Leu  Asp Thr Glu Thr Leu  Gly Thr Cys Ile Asp  Phe Gln Val 
    1100                 1105                 1110             


Val Pro  Gly Cys Gly Ile Ser  Cys Lys Val Thr Asn  Ile Glu Gly 
    1115                 1120                 1125             


Leu Leu  His Lys Asn Asn Trp  Asn Ile Glu Asp Asn  Asn Ile Lys 
    1130                 1135                 1140             


Asn Ala  Ser Leu Val Gln Ile  Asp Ala Ser Asn Glu  Gln Ser Ser 
    1145                 1150                 1155             


Thr Ser  Ser Ser Met Ile Ile  Asp Ala Gln Ile Ser  Asn Ala Leu 
    1160                 1165                 1170             


Asn Ala  Gln Gln Tyr Lys Val  Leu Ile Gly Asn Arg  Glu Trp Met 
    1175                 1180                 1185             


Ile Arg  Asn Gly Leu Val Ile  Asn Asn Asp Val Asn  Asp Phe Met 
    1190                 1195                 1200             


Thr Glu  His Glu Arg Lys Gly  Arg Thr Ala Val Leu  Val Ala Val 
    1205                 1210                 1215             


Asp Asp  Glu Leu Cys Gly Leu  Ile Ala Ile Ala Asp  Thr Val Lys 
    1220                 1225                 1230             


Pro Glu  Ala Glu Leu Ala Ile  His Ile Leu Lys Ser  Met Gly Leu 
    1235                 1240                 1245             


Glu Val  Val Leu Met Thr Gly  Asp Asn Ser Lys Thr  Ala Arg Ser 
    1250                 1255                 1260             


Ile Ala  Ser Gln Val Gly Ile  Thr Lys Val Phe Ala  Glu Val Leu 
    1265                 1270                 1275             


Pro Ser  His Lys Val Ala Lys  Val Lys Gln Leu Gln  Glu Glu Gly 
    1280                 1285                 1290             


Lys Arg  Val Ala Met Val Gly  Asp Gly Ile Asn Asp  Ser Pro Ala 
    1295                 1300                 1305             


Leu Ala  Met Ala Asn Val Gly  Ile Ala Ile Gly Thr  Gly Thr Asp 
    1310                 1315                 1320             


Val Ala  Ile Glu Ala Ala Asp  Val Val Leu Ile Arg  Asn Asp Leu 
    1325                 1330                 1335             


Leu Asp  Val Val Ala Ser Ile  Asp Leu Ser Arg Lys  Thr Val Lys 
    1340                 1345                 1350             


Arg Ile  Arg Ile Asn Phe Val  Phe Ala Leu Ile Tyr  Asn Leu Val 
    1355                 1360                 1365             


Gly Ile  Pro Ile Ala Ala Gly  Val Phe Met Pro Ile  Gly Leu Val 
    1370                 1375                 1380             


Leu Gln  Pro Trp Met Gly Ser  Ala Ala Met Ala Ala  Ser Ser Val 
    1385                 1390                 1395             


Ser Val  Val Leu Ser Ser Leu  Phe Leu Lys Leu Tyr  Arg Lys Pro 
    1400                 1405                 1410             


Thr Tyr  Glu Ser Tyr Glu Leu  Pro Ala Arg Ser Gln  Ile Gly Gln 
    1415                 1420                 1425             


Lys Ser  Pro Ser Glu Ile Ser  Val His Val Gly Ile  Asp Asp Thr 
    1430                 1435                 1440             


Ser Arg  Asn Ser Pro Lys Leu  Gly Leu Leu Asp Arg  Ile Val Asn 
    1445                 1450                 1455             


Tyr Ser  Arg Ala Ser Ile Asn  Ser Leu Leu Ser Asp  Lys Arg Ser 
    1460                 1465                 1470             


Leu Asn  Ser Val Val Thr Ser  Glu Pro Asp Lys His  Ser Leu Leu 
    1475                 1480                 1485             


Val Gly  Asp Phe Arg Glu Asp  Asp Asp Thr Ala Leu  
    1490                 1495                 1500 


<210>  963
<211>  1258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP7B__Homo_sapiens__NP_001005918

<400>  963

Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Ser 
    610                 615                 620                 


Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala Thr Glu 
625                 630                 635                 640 


Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg Glu Glu 
                645                 650                 655     


Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys Val Val 
            660                 665                 670         


Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly Asn Thr 
        675                 680                 685             


Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val Thr Lys 
    690                 695                 700                 


Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His Gly Ser 
705                 710                 715                 720 


Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu Ala Gln 
                725                 730                 735     


Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Asn Pro Asn Lys 
            740                 745                 750         


His Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser 
        755                 760                 765             


Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr 
    770                 775                 780                 


Pro Thr Ala Val Met Val Gly Thr Gly Val Ala Ala Gln Asn Gly Ile 
785                 790                 795                 800 


Leu Ile Lys Gly Gly Lys Pro Leu Glu Met Ala His Lys Ile Lys Thr 
                805                 810                 815     


Val Met Phe Asp Lys Thr Gly Thr Ile Thr His Gly Val Pro Arg Val 
            820                 825                 830         


Met Arg Val Leu Leu Leu Gly Asp Val Ala Thr Leu Pro Leu Arg Lys 
        835                 840                 845             


Val Leu Ala Val Val Gly Thr Ala Glu Ala Ser Ser Glu His Pro Leu 
    850                 855                 860                 


Gly Val Ala Val Thr Lys Tyr Cys Lys Glu Glu Leu Gly Thr Glu Thr 
865                 870                 875                 880 


Leu Gly Tyr Cys Thr Asp Phe Gln Ala Val Pro Gly Cys Gly Ile Gly 
                885                 890                 895     


Cys Lys Val Ser Asn Val Glu Gly Ile Leu Ala His Ser Glu Arg Pro 
            900                 905                 910         


Leu Ser Ala Pro Ala Ser His Leu Asn Glu Ala Gly Ser Leu Pro Ala 
        915                 920                 925             


Glu Lys Asp Ala Val Pro Gln Thr Phe Ser Val Leu Ile Gly Asn Arg 
    930                 935                 940                 


Glu Trp Leu Arg Arg Asn Gly Leu Thr Ile Ser Ser Asp Val Ser Asp 
945                 950                 955                 960 


Ala Met Thr Asp His Glu Met Lys Gly Gln Thr Ala Ile Leu Val Ala 
                965                 970                 975     


Ile Asp Gly Val Leu Cys Gly Met Ile Ala Ile Ala Asp Ala Val Lys 
            980                 985                 990         


Gln Glu Ala Ala Leu Ala Val His  Thr Leu Gln Ser Met  Gly Val Asp 
        995                 1000                 1005             


Val Val  Leu Ile Thr Gly Asp  Asn Arg Lys Thr Ala  Arg Ala Ile 
    1010                 1015                 1020             


Ala Thr  Gln Val Gly Ile Asn  Lys Val Phe Ala Glu  Val Leu Pro 
    1025                 1030                 1035             


Ser His  Lys Val Ala Lys Val  Gln Glu Leu Gln Asn  Lys Gly Lys 
    1040                 1045                 1050             


Lys Val  Ala Met Val Gly Asp  Gly Val Asn Asp Ser  Pro Ala Leu 
    1055                 1060                 1065             


Ala Gln  Ala Asp Met Gly Val  Ala Ile Gly Thr Gly  Thr Asp Val 
    1070                 1075                 1080             


Ala Ile  Glu Ala Ala Asp Val  Val Leu Ile Arg Asn  Asp Leu Leu 
    1085                 1090                 1095             


Asp Val  Val Ala Ser Ile His  Leu Ser Lys Arg Thr  Val Arg Arg 
    1100                 1105                 1110             


Ile Arg  Ile Asn Leu Val Leu  Ala Leu Ile Tyr Asn  Leu Val Gly 
    1115                 1120                 1125             


Ile Pro  Ile Ala Ala Gly Val  Phe Met Pro Ile Gly  Ile Val Leu 
    1130                 1135                 1140             


Gln Pro  Trp Met Gly Ser Ala  Ala Met Ala Ala Ser  Ser Val Ser 
    1145                 1150                 1155             


Val Val  Leu Ser Ser Leu Gln  Leu Lys Cys Tyr Lys  Lys Pro Asp 
    1160                 1165                 1170             


Leu Glu  Arg Tyr Glu Ala Gln  Ala His Gly His Met  Lys Pro Leu 
    1175                 1180                 1185             


Thr Ala  Ser Gln Val Ser Val  His Ile Gly Met Asp  Asp Arg Trp 
    1190                 1195                 1200             


Arg Asp  Ser Pro Arg Ala Thr  Pro Trp Asp Gln Val  Ser Tyr Val 
    1205                 1210                 1215             


Ser Gln  Val Ser Leu Ser Ser  Leu Thr Ser Asp Lys  Pro Ser Arg 
    1220                 1225                 1230             


His Ser  Ala Ala Ala Asp Asp  Asp Gly Asp Lys Trp  Ser Leu Leu 
    1235                 1240                 1245             


Leu Asn  Gly Arg Asp Glu Glu  Gln Tyr Ile 
    1250                 1255             


<210>  964
<211>  1149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP8A1__Homo_sapiens__NP_001098999

<400>  964

Met Pro Thr Met Arg Arg Thr Val Ser Glu Ile Arg Ser Arg Ala Glu 
1               5                   10                  15      


Gly Tyr Glu Lys Thr Asp Asp Val Ser Glu Lys Thr Ser Leu Ala Asp 
            20                  25                  30          


Gln Glu Glu Val Arg Thr Ile Phe Ile Asn Gln Pro Gln Leu Thr Lys 
        35                  40                  45              


Phe Cys Asn Asn His Val Ser Thr Ala Lys Tyr Asn Ile Ile Thr Phe 
    50                  55                  60                  


Leu Pro Arg Phe Leu Tyr Ser Gln Phe Arg Arg Ala Ala Asn Ser Phe 
65                  70                  75                  80  


Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val Ser Pro Thr 
                85                  90                  95      


Gly Arg Tyr Thr Thr Leu Val Pro Leu Leu Phe Ile Leu Ala Val Ala 
            100                 105                 110         


Ala Ile Lys Glu Ile Ile Glu Asp Ile Lys Arg His Lys Ala Asp Asn 
        115                 120                 125             


Ala Val Asn Lys Lys Gln Thr Gln Val Leu Arg Asn Gly Ala Trp Glu 
    130                 135                 140                 


Ile Val His Trp Glu Lys Val Asn Val Gly Asp Ile Val Ile Ile Lys 
145                 150                 155                 160 


Gly Lys Glu Tyr Ile Pro Ala Asp Thr Val Leu Leu Ser Ser Ser Glu 
                165                 170                 175     


Pro Gln Ala Met Cys Tyr Ile Glu Thr Ser Asn Leu Asp Gly Glu Thr 
            180                 185                 190         


Asn Leu Lys Ile Arg Gln Gly Leu Pro Ala Thr Ser Asp Ile Lys Asp 
        195                 200                 205             


Val Asp Ser Leu Met Arg Ile Ser Gly Arg Ile Glu Cys Glu Ser Pro 
    210                 215                 220                 


Asn Arg His Leu Tyr Asp Phe Val Gly Asn Ile Arg Leu Asp Gly His 
225                 230                 235                 240 


Gly Thr Val Pro Leu Gly Ala Asp Gln Ile Leu Leu Arg Gly Ala Gln 
                245                 250                 255     


Leu Arg Asn Thr Gln Trp Val His Gly Ile Val Val Tyr Thr Gly His 
            260                 265                 270         


Asp Thr Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu Ser 
        275                 280                 285             


Asn Val Glu Arg Ile Thr Asn Val Gln Ile Leu Ile Leu Phe Cys Ile 
    290                 295                 300                 


Leu Ile Ala Met Ser Leu Val Cys Ser Val Gly Ser Ala Ile Trp Asn 
305                 310                 315                 320 


Arg Arg His Ser Gly Lys Asp Trp Tyr Leu Asn Leu Asn Tyr Gly Gly 
                325                 330                 335     


Ala Ser Asn Phe Gly Leu Asn Phe Leu Thr Phe Ile Ile Leu Phe Asn 
            340                 345                 350         


Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val Val Lys Phe 
        355                 360                 365             


Thr Gln Ala Tyr Phe Ile Asn Trp Asp Leu Asp Met His Tyr Glu Pro 
    370                 375                 380                 


Thr Asp Thr Ala Ala Met Ala Arg Thr Ser Asn Leu Asn Glu Glu Leu 
385                 390                 395                 400 


Gly Gln Val Lys Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Cys 
                405                 410                 415     


Asn Val Met Gln Phe Lys Lys Cys Thr Ile Ala Gly Val Ala Tyr Gly 
            420                 425                 430         


Gln Asn Ser Gln Phe Gly Asp Glu Lys Thr Phe Ser Asp Ser Ser Leu 
        435                 440                 445             


Leu Glu Asn Leu Gln Asn Asn His Pro Thr Ala Pro Ile Ile Cys Glu 
    450                 455                 460                 


Phe Leu Thr Met Met Ala Val Cys His Thr Ala Val Pro Glu Arg Glu 
465                 470                 475                 480 


Gly Asp Lys Ile Ile Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu 
                485                 490                 495     


Val Arg Ala Ala Lys Gln Leu Asn Phe Val Phe Thr Gly Arg Thr Pro 
            500                 505                 510         


Asp Ser Val Ile Ile Asp Ser Leu Gly Gln Glu Glu Arg Tyr Glu Leu 
        515                 520                 525             


Leu Asn Val Leu Glu Phe Thr Ser Ala Arg Lys Arg Met Ser Val Ile 
    530                 535                 540                 


Val Arg Thr Pro Ser Gly Lys Leu Arg Leu Tyr Cys Lys Gly Ala Asp 
545                 550                 555                 560 


Thr Val Ile Tyr Asp Arg Leu Ala Glu Thr Ser Lys Tyr Lys Glu Ile 
                565                 570                 575     


Thr Leu Lys His Leu Glu Gln Phe Ala Thr Glu Gly Leu Arg Thr Leu 
            580                 585                 590         


Cys Phe Ala Val Ala Glu Ile Ser Glu Ser Asp Phe Gln Glu Trp Arg 
        595                 600                 605             


Ala Val Tyr Gln Arg Ala Ser Thr Ser Val Gln Asn Arg Leu Leu Lys 
    610                 615                 620                 


Leu Glu Glu Ser Tyr Glu Leu Ile Glu Lys Asn Leu Gln Leu Leu Gly 
625                 630                 635                 640 


Ala Thr Ala Ile Glu Asp Lys Leu Gln Asp Gln Val Pro Glu Thr Ile 
                645                 650                 655     


Glu Thr Leu Met Lys Ala Asp Ile Lys Ile Trp Ile Leu Thr Gly Asp 
            660                 665                 670         


Lys Gln Glu Thr Ala Ile Asn Ile Gly His Ser Cys Lys Leu Leu Lys 
        675                 680                 685             


Lys Asn Met Gly Met Ile Val Ile Asn Glu Gly Ser Leu Asp Gly Thr 
    690                 695                 700                 


Arg Glu Thr Leu Ser Arg His Cys Thr Thr Leu Gly Asp Ala Leu Arg 
705                 710                 715                 720 


Lys Glu Asn Asp Phe Ala Leu Ile Ile Asp Gly Lys Thr Leu Lys Tyr 
                725                 730                 735     


Ala Leu Thr Phe Gly Val Arg Gln Tyr Phe Leu Asp Leu Ala Leu Ser 
            740                 745                 750         


Cys Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln Lys Ser Glu 
        755                 760                 765             


Val Val Glu Met Val Lys Lys Gln Val Lys Val Val Thr Leu Ala Ile 
    770                 775                 780                 


Gly Asp Gly Ala Asn Asp Val Ser Met Ile Gln Thr Ala His Val Gly 
785                 790                 795                 800 


Val Gly Ile Ser Gly Asn Glu Gly Leu Gln Ala Ala Asn Ser Ser Asp 
                805                 810                 815     


Tyr Ser Ile Ala Gln Phe Lys Tyr Leu Lys Asn Leu Leu Met Ile His 
            820                 825                 830         


Gly Ala Trp Asn Tyr Asn Arg Val Ser Lys Cys Ile Leu Tyr Cys Phe 
        835                 840                 845             


Tyr Lys Asn Ile Val Leu Tyr Ile Ile Glu Ile Trp Phe Ala Phe Val 
    850                 855                 860                 


Asn Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys Ile Gly Leu 
865                 870                 875                 880 


Tyr Asn Val Met Phe Thr Ala Met Pro Pro Leu Thr Leu Gly Ile Phe 
                885                 890                 895     


Glu Arg Ser Cys Arg Lys Glu Asn Met Leu Lys Tyr Pro Glu Leu Tyr 
            900                 905                 910         


Lys Thr Ser Gln Asn Ala Leu Asp Phe Asn Thr Lys Val Phe Trp Val 
        915                 920                 925             


His Cys Leu Asn Gly Leu Phe His Ser Val Ile Leu Phe Trp Phe Pro 
    930                 935                 940                 


Leu Lys Ala Leu Gln Tyr Gly Thr Ala Phe Gly Asn Gly Lys Thr Ser 
945                 950                 955                 960 


Asp Tyr Leu Leu Leu Gly Asn Phe Val Tyr Thr Phe Val Val Ile Thr 
                965                 970                 975     


Val Cys Leu Lys Ala Gly Leu Glu Thr Ser Tyr Trp Thr Trp Phe Ser 
            980                 985                 990         


His Ile Ala Ile Trp Gly Ser Ile  Ala Leu Trp Val Val  Phe Phe Gly 
        995                 1000                 1005             


Ile Tyr  Ser Ser Leu Trp Pro  Ala Ile Pro Met Ala  Pro Asp Met 
    1010                 1015                 1020             


Ser Gly  Glu Ala Ala Met Leu  Phe Ser Ser Gly Val  Phe Trp Met 
    1025                 1030                 1035             


Gly Leu  Leu Phe Ile Pro Val  Ala Ser Leu Leu Leu  Asp Val Val 
    1040                 1045                 1050             


Tyr Lys  Val Ile Lys Arg Thr  Ala Phe Lys Thr Leu  Val Asp Glu 
    1055                 1060                 1065             


Val Gln  Glu Leu Glu Ala Lys  Ser Gln Asp Pro Gly  Ala Val Val 
    1070                 1075                 1080             


Leu Gly  Lys Ser Leu Thr Glu  Arg Ala Gln Leu Leu  Lys Asn Val 
    1085                 1090                 1095             


Phe Lys  Lys Asn His Val Asn  Leu Tyr Arg Ser Glu  Ser Leu Gln 
    1100                 1105                 1110             


Gln Asn  Leu Leu His Gly Tyr  Ala Phe Ser Gln Asp  Glu Asn Gly 
    1115                 1120                 1125             


Ile Val  Ser Gln Ser Glu Val  Ile Arg Ala Tyr Asp  Thr Thr Lys 
    1130                 1135                 1140             


Gln Arg  Pro Asp Glu Trp 
    1145                 


<210>  965
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP8A2__Homo_sapiens__NP_057613

<400>  965

Met Leu Asn Gly Ala Gly Leu Asp Lys Ala Leu Lys Met Ser Leu Pro 
1               5                   10                  15      


Arg Arg Ser Arg Ile Arg Ser Ser Val Gly Pro Val Arg Ser Ser Leu 
            20                  25                  30          


Gly Tyr Lys Lys Ala Glu Asp Glu Met Ser Arg Ala Thr Ser Val Gly 
        35                  40                  45              


Asp Gln Leu Glu Ala Pro Ala Arg Thr Ile Tyr Leu Asn Gln Pro His 
    50                  55                  60                  


Leu Asn Lys Phe Arg Asp Asn Gln Ile Ser Thr Ala Lys Tyr Ser Val 
65                  70                  75                  80  


Leu Thr Phe Leu Pro Arg Phe Leu Tyr Glu Gln Ile Arg Arg Ala Ala 
                85                  90                  95      


Asn Ala Phe Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val 
            100                 105                 110         


Ser Pro Thr Gly Arg Tyr Thr Thr Leu Val Pro Leu Ile Ile Ile Leu 
        115                 120                 125             


Thr Ile Ala Gly Ile Lys Glu Ile Val Glu Asp Phe Lys Arg His Lys 
    130                 135                 140                 


Ala Asp Asn Ala Val Asn Lys Lys Lys Thr Ile Val Leu Arg Asn Gly 
145                 150                 155                 160 


Met Trp His Thr Ile Met Trp Lys Glu Val Ala Val Gly Asp Ile Val 
                165                 170                 175     


Lys Val Val Asn Gly Gln Tyr Leu Pro Ala Asp Val Val Leu Leu Ser 
            180                 185                 190         


Ser Ser Glu Pro Gln Ala Met Cys Tyr Val Glu Thr Ala Asn Leu Asp 
        195                 200                 205             


Gly Glu Thr Asn Leu Lys Ile Arg Gln Gly Leu Ser His Thr Ala Asp 
    210                 215                 220                 


Met Gln Thr Arg Glu Val Leu Met Lys Leu Ser Gly Thr Ile Glu Cys 
225                 230                 235                 240 


Glu Gly Pro Asn Arg His Leu Tyr Asp Phe Thr Gly Asn Leu Asn Leu 
                245                 250                 255     


Asp Gly Lys Ser Leu Val Ala Leu Gly Pro Asp Gln Ile Leu Leu Arg 
            260                 265                 270         


Gly Thr Gln Leu Arg Asn Thr Gln Trp Val Phe Gly Ile Val Val Tyr 
        275                 280                 285             


Thr Gly His Asp Thr Lys Leu Met Gln Asn Ser Thr Lys Ala Pro Leu 
    290                 295                 300                 


Lys Arg Ser Asn Val Glu Lys Val Thr Asn Val Gln Ile Leu Val Leu 
305                 310                 315                 320 


Phe Gly Ile Leu Leu Val Met Ala Leu Val Ser Ser Ala Gly Ala Leu 
                325                 330                 335     


Tyr Trp Asn Arg Ser His Gly Glu Lys Asn Trp Tyr Ile Lys Lys Met 
            340                 345                 350         


Asp Thr Thr Ser Asp Asn Phe Gly Tyr Asn Leu Leu Thr Phe Ile Ile 
        355                 360                 365             


Leu Tyr Asn Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val 
    370                 375                 380                 


Val Lys Tyr Thr Gln Ala Leu Phe Ile Asn Trp Asp Thr Asp Met Tyr 
385                 390                 395                 400 


Tyr Ile Gly Asn Asp Thr Pro Ala Met Ala Arg Thr Ser Asn Leu Asn 
                405                 410                 415     


Glu Glu Leu Gly Gln Val Lys Tyr Leu Phe Ser Asp Lys Thr Gly Thr 
            420                 425                 430         


Leu Thr Cys Asn Ile Met Asn Phe Lys Lys Cys Ser Ile Ala Gly Val 
        435                 440                 445             


Thr Tyr Gly His Phe Pro Glu Leu Ala Arg Glu Pro Ser Ser Asp Asp 
    450                 455                 460                 


Phe Cys Arg Met Pro Pro Pro Cys Ser Asp Ser Cys Asp Phe Asp Asp 
465                 470                 475                 480 


Pro Arg Leu Leu Lys Asn Ile Glu Asp Arg His Pro Thr Ala Pro Cys 
                485                 490                 495     


Ile Gln Glu Phe Leu Thr Leu Leu Ala Val Cys His Thr Val Val Pro 
            500                 505                 510         


Glu Lys Asp Gly Asp Asn Ile Ile Tyr Gln Ala Ser Ser Pro Asp Glu 
        515                 520                 525             


Ala Ala Leu Val Lys Gly Ala Lys Lys Leu Gly Phe Val Phe Thr Ala 
    530                 535                 540                 


Arg Thr Pro Phe Ser Val Ile Ile Glu Ala Met Gly Gln Glu Gln Thr 
545                 550                 555                 560 


Phe Gly Ile Leu Asn Val Leu Glu Phe Ser Ser Asp Arg Lys Arg Met 
                565                 570                 575     


Ser Val Ile Val Arg Thr Pro Ser Gly Arg Leu Arg Leu Tyr Cys Lys 
            580                 585                 590         


Gly Ala Asp Asn Val Ile Phe Glu Arg Leu Ser Lys Asp Ser Lys Tyr 
        595                 600                 605             


Met Glu Glu Thr Leu Cys His Leu Glu Tyr Phe Ala Thr Glu Gly Leu 
    610                 615                 620                 


Arg Thr Leu Cys Val Ala Tyr Ala Asp Leu Ser Glu Asn Glu Tyr Glu 
625                 630                 635                 640 


Glu Trp Leu Lys Val Tyr Gln Glu Ala Ser Thr Ile Leu Lys Asp Arg 
                645                 650                 655     


Ala Gln Arg Leu Glu Glu Cys Tyr Glu Ile Ile Glu Lys Asn Leu Leu 
            660                 665                 670         


Leu Leu Gly Ala Thr Ala Ile Glu Asp Arg Leu Gln Ala Gly Val Pro 
        675                 680                 685             


Glu Thr Ile Ala Thr Leu Leu Lys Ala Glu Ile Lys Ile Trp Val Leu 
    690                 695                 700                 


Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile Gly Tyr Ser Cys Arg 
705                 710                 715                 720 


Leu Val Ser Gln Asn Met Ala Leu Ile Leu Leu Lys Glu Asp Ser Leu 
                725                 730                 735     


Asp Ala Thr Arg Ala Ala Ile Thr Gln His Cys Thr Asp Leu Gly Asn 
            740                 745                 750         


Leu Leu Gly Lys Glu Asn Asp Val Ala Leu Ile Ile Asp Gly His Thr 
        755                 760                 765             


Leu Lys Tyr Ala Leu Ser Phe Glu Val Arg Arg Ser Phe Leu Asp Leu 
    770                 775                 780                 


Ala Leu Ser Cys Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln 
785                 790                 795                 800 


Lys Ser Glu Ile Val Asp Val Val Lys Lys Arg Val Lys Ala Ile Thr 
                805                 810                 815     


Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Gly Met Ile Gln Thr Ala 
            820                 825                 830         


His Val Gly Val Gly Ile Ser Gly Asn Glu Gly Met Gln Ala Thr Asn 
        835                 840                 845             


Asn Ser Asp Tyr Ala Ile Ala Gln Phe Ser Tyr Leu Glu Lys Leu Leu 
    850                 855                 860                 


Leu Val His Gly Ala Trp Ser Tyr Asn Arg Val Thr Lys Cys Ile Leu 
865                 870                 875                 880 


Tyr Cys Phe Tyr Lys Asn Val Val Leu Tyr Ile Ile Glu Leu Trp Phe 
                885                 890                 895     


Ala Phe Val Asn Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys 
            900                 905                 910         


Ile Gly Leu Tyr Asn Val Ile Phe Thr Ala Leu Pro Pro Phe Thr Leu 
        915                 920                 925             


Gly Ile Phe Glu Arg Ser Cys Thr Gln Glu Ser Met Leu Arg Phe Pro 
    930                 935                 940                 


Gln Leu Tyr Lys Ile Thr Gln Asn Gly Glu Gly Phe Asn Thr Lys Val 
945                 950                 955                 960 


Phe Trp Gly His Cys Ile Asn Ala Leu Val His Ser Leu Ile Leu Phe 
                965                 970                 975     


Trp Phe Pro Met Lys Ala Leu Glu His Asp Thr Val Leu Thr Ser Gly 
            980                 985                 990         


His Ala Thr Asp Tyr Leu Phe Val  Gly Asn Ile Val Tyr  Thr Tyr Val 
        995                 1000                 1005             


Val Val  Thr Val Cys Leu Lys  Ala Gly Leu Glu Thr  Thr Ala Trp 
    1010                 1015                 1020             


Thr Lys  Phe Ser His Leu Ala  Val Trp Gly Ser Met  Leu Thr Trp 
    1025                 1030                 1035             


Leu Val  Phe Phe Gly Ile Tyr  Ser Thr Ile Trp Pro  Thr Ile Pro 
    1040                 1045                 1050             


Ile Ala  Pro Asp Met Arg Gly  Gln Ala Thr Met Val  Leu Ser Ser 
    1055                 1060                 1065             


Ala His  Phe Trp Leu Gly Leu  Phe Leu Val Pro Thr  Ala Cys Leu 
    1070                 1075                 1080             


Ile Glu  Asp Val Ala Trp Arg  Ala Ala Lys His Thr  Cys Lys Lys 
    1085                 1090                 1095             


Thr Leu  Leu Glu Glu Val Gln  Glu Leu Glu Thr Lys  Ser Arg Val 
    1100                 1105                 1110             


Leu Gly  Lys Ala Val Leu Arg  Asp Ser Asn Gly Lys  Arg Leu Asn 
    1115                 1120                 1125             


Glu Arg  Asp Arg Leu Ile Lys  Arg Leu Gly Arg Lys  Thr Pro Pro 
    1130                 1135                 1140             


Thr Leu  Phe Arg Gly Ser Ser  Leu Gln Gln Gly Val  Pro His Gly 
    1145                 1150                 1155             


Tyr Ala  Phe Ser Gln Glu Glu  His Gly Ala Val Ser  Gln Glu Glu 
    1160                 1165                 1170             


Val Ile  Arg Ala Tyr Asp Thr  Thr Lys Lys Lys Ser  Arg Lys Lys 
    1175                 1180                 1185             


<210>  966
<211>  1251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP8B1__Homo_sapiens__XP_011524324

<400>  966

Met Ser Thr Glu Arg Asp Ser Glu Thr Thr Phe Asp Glu Asp Ser Gln 
1               5                   10                  15      


Pro Asn Asp Glu Val Val Pro Tyr Ser Asp Asp Glu Thr Glu Asp Glu 
            20                  25                  30          


Leu Asp Asp Gln Gly Ser Ala Val Glu Pro Glu Gln Asn Arg Val Asn 
        35                  40                  45              


Arg Glu Ala Glu Glu Asn Arg Glu Pro Phe Arg Lys Glu Cys Thr Trp 
    50                  55                  60                  


Gln Val Lys Ala Asn Asp Arg Lys Tyr His Glu Gln Pro His Phe Met 
65                  70                  75                  80  


Asn Thr Lys Phe Leu Cys Ile Lys Glu Ser Lys Tyr Ala Asn Asn Ala 
                85                  90                  95      


Ile Lys Thr Tyr Lys Tyr Asn Ala Phe Thr Phe Ile Pro Met Asn Leu 
            100                 105                 110         


Phe Glu Gln Phe Lys Arg Ala Ala Asn Leu Tyr Phe Leu Ala Leu Leu 
        115                 120                 125             


Ile Leu Gln Ala Val Pro Gln Ile Ser Thr Leu Ala Trp Tyr Thr Thr 
    130                 135                 140                 


Leu Val Pro Leu Leu Val Val Leu Gly Val Thr Ala Ile Lys Asp Leu 
145                 150                 155                 160 


Val Asp Asp Val Ala Arg His Lys Met Asp Lys Glu Ile Asn Asn Arg 
                165                 170                 175     


Thr Cys Glu Val Ile Lys Asp Gly Arg Phe Lys Val Ala Lys Trp Lys 
            180                 185                 190         


Glu Ile Gln Val Gly Asp Val Ile Arg Leu Lys Lys Asn Asp Phe Val 
        195                 200                 205             


Pro Ala Asp Ile Leu Leu Leu Ser Ser Ser Glu Pro Asn Ser Leu Cys 
    210                 215                 220                 


Tyr Val Glu Thr Ala Glu Leu Asp Gly Glu Thr Asn Leu Lys Phe Lys 
225                 230                 235                 240 


Met Ser Leu Glu Ile Thr Asp Gln Tyr Leu Gln Arg Glu Asp Thr Leu 
                245                 250                 255     


Ala Thr Phe Asp Gly Phe Ile Glu Cys Glu Glu Pro Asn Asn Arg Leu 
            260                 265                 270         


Asp Lys Phe Thr Gly Thr Leu Phe Trp Arg Asn Thr Ser Phe Pro Leu 
        275                 280                 285             


Asp Ala Asp Lys Ile Leu Leu Arg Gly Cys Val Ile Arg Asn Thr Asp 
    290                 295                 300                 


Phe Cys His Gly Leu Val Ile Phe Ala Gly Ala Asp Thr Lys Ile Met 
305                 310                 315                 320 


Lys Asn Ser Gly Lys Thr Arg Phe Lys Arg Thr Lys Ile Asp Tyr Leu 
                325                 330                 335     


Met Asn Tyr Met Val Tyr Thr Ile Phe Val Val Leu Ile Leu Leu Ser 
            340                 345                 350         


Ala Gly Leu Ala Ile Gly His Ala Tyr Trp Glu Ala Gln Val Gly Asn 
        355                 360                 365             


Ser Ser Trp Tyr Leu Tyr Asp Gly Glu Asp Asp Thr Pro Ser Tyr Arg 
    370                 375                 380                 


Gly Phe Leu Ile Phe Trp Gly Tyr Ile Ile Val Leu Asn Thr Met Val 
385                 390                 395                 400 


Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu Gly Gln Ser 
                405                 410                 415     


His Phe Ile Asn Trp Asp Leu Gln Met Tyr Tyr Ala Glu Lys Asp Thr 
            420                 425                 430         


Pro Ala Lys Ala Arg Thr Thr Thr Leu Asn Glu Gln Leu Gly Gln Ile 
        435                 440                 445             


His Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Ile Met 
    450                 455                 460                 


Thr Phe Lys Lys Cys Cys Ile Asn Gly Gln Ile Tyr Gly Asp His Arg 
465                 470                 475                 480 


Asp Ala Ser Gln His Asn His Asn Lys Ile Glu Gln Val Asp Phe Ser 
                485                 490                 495     


Trp Asn Thr Tyr Ala Asp Gly Lys Leu Ala Phe Tyr Asp His Tyr Leu 
            500                 505                 510         


Ile Glu Gln Ile Gln Ser Gly Lys Glu Pro Glu Val Arg Gln Phe Phe 
        515                 520                 525             


Phe Leu Leu Ala Val Cys His Thr Val Met Val Asp Arg Thr Asp Gly 
    530                 535                 540                 


Gln Leu Asn Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu Val Asn 
545                 550                 555                 560 


Ala Ala Arg Asn Phe Gly Phe Ala Phe Leu Ala Arg Thr Gln Asn Thr 
                565                 570                 575     


Ile Thr Ile Ser Glu Leu Gly Thr Glu Arg Thr Tyr Asn Val Leu Ala 
            580                 585                 590         


Ile Leu Asp Phe Asn Ser Asp Arg Lys Arg Met Ser Ile Ile Val Arg 
        595                 600                 605             


Thr Pro Glu Gly Asn Ile Lys Leu Tyr Cys Lys Gly Ala Asp Thr Val 
    610                 615                 620                 


Ile Tyr Glu Arg Leu His Arg Met Asn Pro Thr Lys Gln Glu Thr Gln 
625                 630                 635                 640 


Asp Ala Leu Asp Ile Phe Ala Asn Glu Thr Leu Arg Thr Leu Cys Leu 
                645                 650                 655     


Cys Tyr Lys Glu Ile Glu Glu Lys Glu Phe Thr Glu Trp Asn Lys Lys 
            660                 665                 670         


Phe Met Ala Ala Ser Val Ala Ser Thr Asn Arg Asp Glu Ala Leu Asp 
        675                 680                 685             


Lys Val Tyr Glu Glu Ile Glu Lys Asp Leu Ile Leu Leu Gly Ala Thr 
    690                 695                 700                 


Ala Ile Glu Asp Lys Leu Gln Asp Gly Val Pro Glu Thr Ile Ser Lys 
705                 710                 715                 720 


Leu Ala Lys Ala Asp Ile Lys Ile Trp Val Leu Thr Gly Asp Lys Lys 
                725                 730                 735     


Glu Thr Ala Glu Asn Ile Gly Phe Ala Cys Glu Leu Leu Thr Glu Asp 
            740                 745                 750         


Thr Thr Ile Cys Tyr Gly Glu Asp Ile Asn Ser Leu Leu His Ala Arg 
        755                 760                 765             


Met Glu Asn Gln Arg Asn Arg Gly Gly Val Tyr Ala Lys Phe Ala Pro 
    770                 775                 780                 


Pro Val Gln Glu Ser Phe Phe Pro Pro Gly Gly Asn Arg Ala Leu Ile 
785                 790                 795                 800 


Ile Thr Gly Ser Trp Leu Asn Glu Ile Leu Leu Glu Lys Lys Thr Lys 
                805                 810                 815     


Arg Asn Lys Ile Leu Lys Leu Lys Phe Pro Arg Thr Glu Glu Glu Arg 
            820                 825                 830         


Arg Met Arg Thr Gln Ser Lys Arg Arg Leu Glu Ala Lys Lys Glu Gln 
        835                 840                 845             


Arg Gln Lys Asn Phe Val Asp Leu Ala Cys Glu Cys Ser Ala Val Ile 
    850                 855                 860                 


Cys Cys Arg Val Thr Pro Lys Gln Lys Ala Met Val Val Asp Leu Val 
865                 870                 875                 880 


Lys Arg Tyr Lys Lys Ala Ile Thr Leu Ala Ile Gly Asp Gly Ala Asn 
                885                 890                 895     


Asp Val Asn Met Ile Lys Thr Ala His Ile Gly Val Gly Ile Ser Gly 
            900                 905                 910         


Gln Glu Gly Met Gln Ala Val Met Ser Ser Asp Tyr Ser Phe Ala Gln 
        915                 920                 925             


Phe Arg Tyr Leu Gln Arg Leu Leu Leu Val His Gly Arg Trp Ser Tyr 
    930                 935                 940                 


Ile Arg Met Cys Lys Phe Leu Arg Tyr Phe Phe Tyr Lys Asn Phe Ala 
945                 950                 955                 960 


Phe Thr Leu Val His Phe Trp Tyr Ser Phe Phe Asn Gly Tyr Ser Ala 
                965                 970                 975     


Gln Thr Ala Tyr Glu Asp Trp Phe Ile Thr Leu Tyr Asn Val Leu Tyr 
            980                 985                 990         


Thr Ser Leu Pro Val Leu Leu Met  Gly Leu Leu Asp Gln  Asp Val Ser 
        995                 1000                 1005             


Asp Lys  Leu Ser Leu Arg Phe  Pro Gly Leu Tyr Ile  Val Gly Gln 
    1010                 1015                 1020             


Arg Asp  Leu Leu Phe Asn Tyr  Lys Arg Phe Phe Val  Ser Leu Leu 
    1025                 1030                 1035             


His Gly  Val Leu Thr Ser Met  Ile Leu Phe Phe Ile  Pro Leu Gly 
    1040                 1045                 1050             


Ala Tyr  Leu Gln Thr Val Gly  Gln Asp Gly Glu Ala  Pro Ser Asp 
    1055                 1060                 1065             


Tyr Gln  Ser Phe Ala Val Thr  Ile Ala Ser Ala Leu  Val Ile Thr 
    1070                 1075                 1080             


Val Asn  Phe Gln Ile Gly Leu  Asp Thr Ser Tyr Trp  Thr Phe Val 
    1085                 1090                 1095             


Asn Ala  Phe Ser Ile Phe Gly  Ser Ile Ala Leu Tyr  Phe Gly Ile 
    1100                 1105                 1110             


Met Phe  Asp Phe His Ser Ala  Gly Ile His Val Leu  Phe Pro Ser 
    1115                 1120                 1125             


Ala Phe  Gln Phe Thr Gly Thr  Ala Ser Asn Ala Leu  Arg Gln Pro 
    1130                 1135                 1140             


Tyr Ile  Trp Leu Thr Ile Ile  Leu Ala Val Ala Val  Cys Leu Leu 
    1145                 1150                 1155             


Pro Val  Val Ala Ile Arg Phe  Leu Ser Met Thr Ile  Trp Pro Ser 
    1160                 1165                 1170             


Glu Ser  Asp Lys Ile Gln Lys  His Arg Lys Arg Leu  Lys Ala Glu 
    1175                 1180                 1185             


Glu Gln  Trp Gln Arg Arg Gln  Gln Val Phe Arg Arg  Gly Val Ser 
    1190                 1195                 1200             


Thr Arg  Arg Ser Ala Tyr Ala  Phe Ser His Gln Arg  Gly Tyr Ala 
    1205                 1210                 1215             


Asp Leu  Ile Ser Ser Gly Arg  Ser Ile Arg Lys Lys  Arg Ser Pro 
    1220                 1225                 1230             


Leu Asp  Ala Ile Val Ala Asp  Gly Thr Ala Glu Tyr  Arg Arg Thr 
    1235                 1240                 1245             


Gly Asp  Ser 
    1250     


<210>  967
<211>  1263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP8B3__Homo_sapiens__NP_001171473

<400>  967

Met Gly Asp Ser Pro Gly Arg Gly Ala Pro Glu Arg Arg His Lys Ala 
1               5                   10                  15      


Gln Pro Gly Arg Ala Arg Lys Tyr Glu Trp Arg Pro Glu Gly Pro Thr 
            20                  25                  30          


Ser Met Gly Ser Leu Gly Gln Arg Glu Asp Leu Gln Asp Glu Asp Arg 
        35                  40                  45              


Asn Ser Ala Phe Thr Trp Lys Val Gln Ala Asn Asn Arg Ala Tyr Asn 
    50                  55                  60                  


Gly Gln Phe Lys Glu Lys Val Ile Leu Cys Trp Gln Arg Lys Lys Tyr 
65                  70                  75                  80  


Lys Thr Asn Val Ile Arg Thr Ala Lys Tyr Asn Phe Tyr Ser Phe Leu 
                85                  90                  95      


Pro Leu Asn Leu Tyr Glu Gln Phe His Arg Val Ser Asn Leu Phe Phe 
            100                 105                 110         


Leu Ile Ile Ile Ile Leu Gln Ser Ile Pro Asp Ile Ser Thr Leu Pro 
        115                 120                 125             


Trp Phe Ser Leu Ser Thr Pro Met Val Cys Leu Leu Phe Ile Arg Ala 
    130                 135                 140                 


Thr Arg Asp Leu Val Asp Asp Met Gly Arg His Lys Ser Asp Arg Ala 
145                 150                 155                 160 


Ile Asn Asn Arg Pro Cys Gln Ile Leu Met Gly Lys Ser Phe Lys Gln 
                165                 170                 175     


Lys Lys Trp Gln Asp Leu Cys Val Gly Asp Val Val Cys Leu Arg Lys 
            180                 185                 190         


Asp Asn Ile Val Pro Ala Asp Met Leu Leu Leu Ala Ser Thr Glu Pro 
        195                 200                 205             


Ser Ser Leu Cys Tyr Val Glu Thr Val Asp Ile Asp Gly Glu Thr Asn 
    210                 215                 220                 


Leu Lys Phe Arg Gln Ala Leu Met Val Thr His Lys Glu Leu Ala Thr 
225                 230                 235                 240 


Ile Lys Lys Met Ala Ser Phe Gln Gly Thr Val Thr Cys Glu Ala Pro 
                245                 250                 255     


Asn Ser Arg Met His His Phe Val Gly Cys Leu Glu Trp Asn Asp Lys 
            260                 265                 270         


Lys Tyr Ser Leu Asp Ile Gly Asn Leu Leu Leu Arg Gly Cys Arg Ile 
        275                 280                 285             


Arg Asn Thr Asp Thr Cys Tyr Gly Leu Val Ile Tyr Ala Asp Gly Tyr 
    290                 295                 300                 


Met Phe Val Gly Phe Asp Thr Lys Ile Met Lys Asn Cys Gly Lys Ile 
305                 310                 315                 320 


His Leu Lys Arg Thr Lys Leu Asp Leu Leu Met Asn Lys Leu Val Val 
                325                 330                 335     


Val Ile Phe Ile Ser Val Val Leu Val Cys Leu Val Leu Ala Phe Gly 
            340                 345                 350         


Phe Gly Phe Ser Val Lys Glu Phe Lys Asp His His Tyr Tyr Leu Ser 
        355                 360                 365             


Gly Val His Gly Ser Ser Val Ala Ala Glu Ser Phe Phe Val Phe Trp 
    370                 375                 380                 


Ser Phe Leu Ile Leu Leu Ser Val Thr Ile Pro Met Ser Met Phe Ile 
385                 390                 395                 400 


Leu Ser Glu Phe Ile Tyr Leu Gly Asn Ser Val Phe Ile Asp Trp Asp 
                405                 410                 415     


Val Gln Met Tyr Tyr Lys Pro Gln Asp Val Pro Ala Lys Ala Arg Ser 
            420                 425                 430         


Thr Ser Leu Asn Asp His Leu Gly Gln Val Glu Tyr Ile Phe Ser Asp 
        435                 440                 445             


Lys Thr Gly Thr Leu Thr Gln Asn Ile Leu Thr Phe Asn Lys Cys Cys 
    450                 455                 460                 


Ile Ser Gly Arg Val Tyr Gly Pro Asp Ser Glu Ala Thr Thr Arg Pro 
465                 470                 475                 480 


Lys Glu Asn Pro Tyr Leu Trp Asn Lys Phe Ala Asp Gly Lys Leu Leu 
                485                 490                 495     


Phe His Asn Ala Ala Leu Leu His Leu Val Arg Thr Asn Gly Asp Glu 
            500                 505                 510         


Ala Val Arg Glu Phe Trp Arg Leu Leu Ala Ile Cys His Thr Val Met 
        515                 520                 525             


Val Arg Glu Ser Pro Arg Glu Arg Pro Asp Gln Leu Leu Tyr Gln Ala 
    530                 535                 540                 


Ala Ser Pro Asp Glu Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly 
545                 550                 555                 560 


Tyr Val Phe Leu Ser Arg Thr Gln Asp Thr Val Thr Ile Met Glu Leu 
                565                 570                 575     


Gly Glu Glu Arg Val Tyr Gln Val Leu Ala Ile Met Asp Phe Asn Ser 
            580                 585                 590         


Thr Arg Lys Arg Met Ser Val Leu Val Arg Lys Pro Glu Gly Ala Ile 
        595                 600                 605             


Cys Leu Tyr Thr Lys Gly Ala Asp Thr Val Ile Phe Glu Arg Leu His 
    610                 615                 620                 


Arg Arg Gly Ala Met Glu Phe Ala Thr Glu Glu Ala Leu Ala Ala Phe 
625                 630                 635                 640 


Ala Gln Glu Thr Leu Arg Thr Leu Cys Leu Ala Tyr Arg Glu Val Ala 
                645                 650                 655     


Glu Asp Ile Tyr Glu Asp Trp Gln Gln Arg His Gln Glu Ala Ser Leu 
            660                 665                 670         


Leu Leu Gln Asn Arg Ala Gln Ala Leu Gln Gln Val Tyr Asn Glu Met 
        675                 680                 685             


Glu Gln Asp Leu Arg Leu Leu Gly Ala Thr Ala Ile Glu Asp Arg Leu 
    690                 695                 700                 


Gln Asp Gly Val Pro Glu Thr Ile Lys Cys Leu Lys Lys Ser Asn Ile 
705                 710                 715                 720 


Lys Ile Trp Val Leu Thr Gly Asp Lys Gln Glu Thr Ala Val Asn Ile 
                725                 730                 735     


Gly Phe Ala Cys Glu Leu Leu Ser Glu Asn Met Leu Ile Leu Glu Glu 
            740                 745                 750         


Lys Glu Ile Ser Arg Ile Leu Glu Thr Tyr Trp Glu Asn Ser Asn Asn 
        755                 760                 765             


Leu Leu Thr Arg Glu Ser Leu Ser Gln Val Lys Leu Ala Leu Val Ile 
    770                 775                 780                 


Asn Gly Asp Phe Leu Asp Lys Leu Leu Val Ser Leu Arg Lys Glu Pro 
785                 790                 795                 800 


Arg Ala Leu Ala Gln Asn Val Asn Met Asp Glu Ala Trp Gln Glu Leu 
                805                 810                 815     


Gly Gln Ser Arg Arg Asp Phe Leu Tyr Ala Arg Arg Leu Ser Leu Leu 
            820                 825                 830         


Cys Arg Arg Phe Gly Leu Pro Leu Ala Ala Pro Pro Ala Gln Asp Ser 
        835                 840                 845             


Arg Ala Arg Arg Ser Ser Glu Val Leu Gln Glu Arg Ala Phe Val Asp 
    850                 855                 860                 


Leu Ala Ser Lys Cys Gln Ala Val Ile Cys Cys Arg Val Thr Pro Lys 
865                 870                 875                 880 


Gln Lys Ala Leu Ile Val Ala Leu Val Lys Lys Tyr His Gln Val Val 
                885                 890                 895     


Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Ile Asn Met Ile Lys Thr 
            900                 905                 910         


Ala Asp Val Gly Val Gly Leu Ala Gly Gln Glu Gly Met Gln Ala Val 
        915                 920                 925             


Gln Asn Ser Asp Phe Val Leu Gly Gln Phe Cys Phe Leu Gln Arg Leu 
    930                 935                 940                 


Leu Leu Val His Gly Arg Trp Ser Tyr Val Arg Ile Cys Lys Phe Leu 
945                 950                 955                 960 


Arg Tyr Phe Phe Tyr Lys Ser Met Ala Ser Met Met Val Gln Val Trp 
                965                 970                 975     


Phe Ala Cys Tyr Asn Gly Phe Thr Gly Gln Pro Leu Tyr Glu Gly Trp 
            980                 985                 990         


Phe Leu Ala Leu Phe Asn Leu Leu  Tyr Ser Thr Leu Pro  Val Leu Tyr 
        995                 1000                 1005             


Ile Gly  Leu Phe Glu Gln Asp  Val Ser Ala Glu Gln  Ser Leu Glu 
    1010                 1015                 1020             


Lys Pro  Glu Leu Tyr Val Val  Gly Gln Lys Asp Glu  Leu Phe Asn 
    1025                 1030                 1035             


Tyr Trp  Val Phe Val Gln Ala  Ile Ala His Gly Val  Thr Thr Ser 
    1040                 1045                 1050             


Leu Val  Asn Phe Phe Met Thr  Leu Trp Ile Ser Arg  Asp Thr Ala 
    1055                 1060                 1065             


Gly Pro  Ala Ser Phe Ser Asp  His Gln Ser Phe Ala  Val Val Val 
    1070                 1075                 1080             


Ala Leu  Ser Cys Leu Leu Ser  Ile Thr Met Glu Val  Ile Leu Ile 
    1085                 1090                 1095             


Ile Lys  Tyr Trp Thr Ala Leu  Cys Val Ala Thr Ile  Leu Leu Ser 
    1100                 1105                 1110             


Leu Gly  Phe Tyr Ala Ile Met  Thr Thr Thr Thr Gln  Ser Phe Trp 
    1115                 1120                 1125             


Leu Phe  Arg Val Ser Pro Thr  Thr Phe Pro Phe Leu  Tyr Ala Asp 
    1130                 1135                 1140             


Leu Ser  Val Met Ser Ser Pro  Ser Ile Leu Leu Val  Val Leu Leu 
    1145                 1150                 1155             


Ser Val  Ser Ile Asn Thr Phe  Pro Val Leu Ala Leu  Arg Val Ile 
    1160                 1165                 1170             


Phe Pro  Ala Leu Lys Glu Leu  Arg Ala Lys Glu Glu  Lys Val Glu 
    1175                 1180                 1185             


Glu Gly  Pro Ser Glu Glu Ile  Phe Thr Met Glu Pro  Leu Pro His 
    1190                 1195                 1200             


Val His  Arg Glu Ser Arg Ala  Arg Arg Ser Ser Tyr  Ala Phe Ser 
    1205                 1210                 1215             


His Arg  Glu Gly Tyr Ala Asn  Leu Ile Thr Gln Gly  Thr Ile Leu 
    1220                 1225                 1230             


Arg Arg  Gly Pro Gly Val Ser  Ser Asp Ile Ala Ser  Glu Ser Leu 
    1235                 1240                 1245             


Asp Pro  Ser Asp Glu Glu Ala  Ala Ser Ser Pro Lys  Glu Ser Gln 
    1250                 1255                 1260             


<210>  968
<211>  1192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP8B4__Homo_sapiens__NP_079113

<400>  968

Met Phe Cys Ser Glu Lys Lys Leu Arg Glu Val Glu Arg Ile Val Lys 
1               5                   10                  15      


Ala Asn Asp Arg Glu Tyr Asn Glu Lys Phe Gln Tyr Ala Asp Asn Arg 
            20                  25                  30          


Ile His Thr Ser Lys Tyr Asn Ile Leu Thr Phe Leu Pro Ile Asn Leu 
        35                  40                  45              


Phe Glu Gln Phe Gln Arg Val Ala Asn Ala Tyr Phe Leu Cys Leu Leu 
    50                  55                  60                  


Ile Leu Gln Leu Ile Pro Glu Ile Ser Ser Leu Thr Trp Phe Thr Thr 
65                  70                  75                  80  


Ile Val Pro Leu Val Leu Val Ile Thr Met Thr Ala Val Lys Asp Ala 
                85                  90                  95      


Thr Asp Asp Tyr Phe Arg His Lys Ser Asp Asn Gln Val Asn Asn Arg 
            100                 105                 110         


Gln Ser Glu Val Leu Ile Asn Ser Lys Leu Gln Asn Glu Lys Trp Met 
        115                 120                 125             


Asn Val Lys Val Gly Asp Ile Ile Lys Leu Glu Asn Asn Gln Phe Val 
    130                 135                 140                 


Ala Ala Asp Leu Leu Leu Leu Ser Ser Ser Glu Pro His Gly Leu Cys 
145                 150                 155                 160 


Tyr Val Glu Thr Ala Glu Leu Asp Gly Glu Thr Asn Leu Lys Val Arg 
                165                 170                 175     


His Ala Leu Ser Val Thr Ser Glu Leu Gly Ala Asp Ile Ser Arg Leu 
            180                 185                 190         


Ala Gly Phe Asp Gly Ile Val Val Cys Glu Val Pro Asn Asn Lys Leu 
        195                 200                 205             


Asp Lys Phe Met Gly Ile Leu Ser Trp Lys Asp Ser Lys His Ser Leu 
    210                 215                 220                 


Asn Asn Glu Lys Ile Ile Leu Arg Gly Cys Ile Leu Arg Asn Thr Ser 
225                 230                 235                 240 


Trp Cys Phe Gly Met Val Ile Phe Ala Gly Pro Asp Thr Lys Leu Met 
                245                 250                 255     


Gln Asn Ser Gly Lys Thr Lys Phe Lys Arg Thr Ser Ile Asp Arg Leu 
            260                 265                 270         


Met Asn Thr Leu Val Leu Trp Ile Phe Gly Phe Leu Ile Cys Leu Gly 
        275                 280                 285             


Ile Ile Leu Ala Ile Gly Asn Ser Ile Trp Glu Ser Gln Thr Gly Asp 
    290                 295                 300                 


Gln Phe Arg Thr Phe Leu Phe Trp Asn Glu Gly Glu Lys Ser Ser Val 
305                 310                 315                 320 


Phe Ser Gly Phe Leu Thr Phe Trp Ser Tyr Ile Ile Ile Leu Asn Thr 
                325                 330                 335     


Val Val Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu Gly 
            340                 345                 350         


His Ser Tyr Phe Ile Asn Trp Asp Arg Lys Met Tyr Tyr Ser Arg Lys 
        355                 360                 365             


Ala Ile Pro Ala Val Ala Arg Thr Thr Thr Leu Asn Glu Glu Leu Gly 
    370                 375                 380                 


Gln Ile Glu Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
385                 390                 395                 400 


Ile Met Thr Phe Lys Arg Cys Ser Ile Asn Gly Arg Ile Tyr Gly Glu 
                405                 410                 415     


Val His Asp Asp Leu Asp Gln Lys Thr Glu Ile Thr Gln Glu Lys Glu 
            420                 425                 430         


Pro Val Asp Phe Ser Val Lys Ser Gln Ala Asp Arg Glu Phe Gln Phe 
        435                 440                 445             


Phe Asp His His Leu Met Glu Ser Ile Lys Met Gly Asp Pro Lys Val 
    450                 455                 460                 


His Glu Phe Leu Arg Leu Leu Ala Leu Cys His Thr Val Met Ser Glu 
465                 470                 475                 480 


Glu Asn Ser Ala Gly Glu Leu Ile Tyr Gln Val Gln Ser Pro Asp Glu 
                485                 490                 495     


Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Phe Ile Phe Lys Ser 
            500                 505                 510         


Arg Thr Pro Glu Thr Ile Thr Ile Glu Glu Leu Gly Thr Leu Val Thr 
        515                 520                 525             


Tyr Gln Leu Leu Ala Phe Leu Asp Phe Asn Asn Thr Arg Lys Arg Met 
    530                 535                 540                 


Ser Val Ile Val Arg Asn Pro Glu Gly Gln Ile Lys Leu Tyr Ser Lys 
545                 550                 555                 560 


Gly Ala Asp Thr Ile Leu Phe Glu Lys Leu His Pro Ser Asn Glu Val 
                565                 570                 575     


Leu Leu Ser Leu Thr Ser Asp His Leu Ser Glu Phe Ala Gly Glu Gly 
            580                 585                 590         


Leu Arg Thr Leu Ala Ile Ala Tyr Arg Asp Leu Asp Asp Lys Tyr Phe 
        595                 600                 605             


Lys Glu Trp His Lys Met Leu Glu Asp Ala Asn Ala Ala Thr Glu Glu 
    610                 615                 620                 


Arg Asp Glu Arg Ile Ala Gly Leu Tyr Glu Glu Ile Glu Arg Asp Leu 
625                 630                 635                 640 


Met Leu Leu Gly Ala Thr Ala Val Glu Asp Lys Leu Gln Glu Gly Val 
                645                 650                 655     


Ile Glu Thr Val Thr Ser Leu Ser Leu Ala Asn Ile Lys Ile Trp Val 
            660                 665                 670         


Leu Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile Gly Tyr Ala Cys 
        675                 680                 685             


Asn Met Leu Thr Asp Asp Met Asn Asp Val Phe Val Ile Ala Gly Asn 
    690                 695                 700                 


Asn Ala Val Glu Val Arg Glu Glu Leu Arg Lys Ala Lys Gln Asn Leu 
705                 710                 715                 720 


Phe Gly Gln Asn Arg Asn Phe Ser Asn Gly His Val Val Cys Glu Lys 
                725                 730                 735     


Lys Gln Gln Leu Glu Leu Asp Ser Ile Val Glu Glu Thr Ile Thr Gly 
            740                 745                 750         


Asp Tyr Ala Leu Ile Ile Asn Gly His Ser Leu Ala His Ala Leu Glu 
        755                 760                 765             


Ser Asp Val Lys Asn Asp Leu Leu Glu Leu Ala Cys Met Cys Lys Thr 
    770                 775                 780                 


Val Ile Cys Cys Arg Val Thr Pro Leu Gln Lys Ala Gln Val Val Glu 
785                 790                 795                 800 


Leu Val Lys Lys Tyr Arg Asn Ala Val Thr Leu Ala Ile Gly Asp Gly 
                805                 810                 815     


Ala Asn Asp Val Ser Met Ile Lys Ser Ala His Ile Gly Val Gly Ile 
            820                 825                 830         


Ser Gly Gln Glu Gly Leu Gln Ala Val Leu Ala Ser Asp Tyr Ser Phe 
        835                 840                 845             


Ala Gln Phe Arg Tyr Leu Gln Arg Leu Leu Leu Val His Gly Arg Trp 
    850                 855                 860                 


Ser Tyr Phe Arg Met Cys Lys Phe Leu Cys Tyr Phe Phe Tyr Lys Asn 
865                 870                 875                 880 


Phe Ala Phe Thr Leu Val His Phe Trp Phe Gly Phe Phe Cys Gly Phe 
                885                 890                 895     


Ser Ala Gln Thr Val Tyr Asp Gln Trp Phe Ile Thr Leu Phe Asn Ile 
            900                 905                 910         


Val Tyr Thr Ser Leu Pro Val Leu Ala Met Gly Ile Phe Asp Gln Asp 
        915                 920                 925             


Val Ser Asp Gln Asn Ser Val Asp Cys Pro Gln Leu Tyr Lys Pro Gly 
    930                 935                 940                 


Gln Leu Asn Leu Leu Phe Asn Lys Arg Lys Phe Phe Ile Cys Val Leu 
945                 950                 955                 960 


His Gly Ile Tyr Thr Ser Leu Val Leu Phe Phe Ile Pro Tyr Gly Ala 
                965                 970                 975     


Phe Tyr Asn Val Ala Gly Glu Asp Gly Gln His Ile Ala Asp Tyr Gln 
            980                 985                 990         


Ser Phe Ala Val Thr Met Ala Thr  Ser Leu Val Ile Val  Val Ser Val 
        995                 1000                 1005             


Gln Ile  Ala Leu Asp Thr Ser  Tyr Trp Thr Phe Ile  Asn His Val 
    1010                 1015                 1020             


Phe Ile  Trp Gly Ser Ile Ala  Ile Tyr Phe Ser Ile  Leu Phe Thr 
    1025                 1030                 1035             


Met His  Ser Asn Gly Ile Phe  Gly Ile Phe Pro Asn  Gln Phe Pro 
    1040                 1045                 1050             


Phe Val  Gly Asn Ala Arg His  Ser Leu Thr Gln Lys  Cys Ile Trp 
    1055                 1060                 1065             


Leu Val  Ile Leu Leu Thr Thr  Val Ala Ser Val Met  Pro Val Val 
    1070                 1075                 1080             


Ala Phe  Arg Phe Leu Lys Val  Asp Leu Tyr Pro Thr  Leu Ser Asp 
    1085                 1090                 1095             


Gln Ile  Arg Arg Trp Gln Lys  Ala Gln Lys Lys Ala  Arg Pro Pro 
    1100                 1105                 1110             


Ser Ser  Arg Arg Pro Arg Thr  Arg Arg Ser Ser Ser  Arg Arg Ser 
    1115                 1120                 1125             


Gly Tyr  Ala Phe Ala His Gln  Glu Gly Tyr Gly Glu  Leu Ile Thr 
    1130                 1135                 1140             


Ser Gly  Lys Asn Met Arg Ala  Lys Asn Pro Pro Pro  Thr Ser Gly 
    1145                 1150                 1155             


Leu Glu  Lys Thr His Tyr Asn  Ser Thr Ser Trp Ile  Glu Asn Leu 
    1160                 1165                 1170             


Cys Lys  Lys Thr Thr Asp Thr  Val Ser Ser Phe Ser  Gln Asp Lys 
    1175                 1180                 1185             


Thr Val  Lys Leu 
    1190         


<210>  969
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP9B__Homo_sapiens__NP_940933

<400>  969

Met Ala Asp Gln Ile Pro Leu Tyr Pro Val Arg Ser Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Asn Arg Lys Arg Ala Ala Tyr Tyr Ser Ala Ala Gly Pro Arg 
            20                  25                  30          


Pro Gly Ala Asp Arg His Ser Arg Tyr Gln Leu Glu Asp Glu Ser Ala 
        35                  40                  45              


His Leu Asp Glu Met Pro Leu Met Met Ser Glu Glu Gly Phe Glu Asn 
    50                  55                  60                  


Glu Glu Ser Asp Tyr His Thr Leu Pro Arg Ala Arg Ile Met Gln Arg 
65                  70                  75                  80  


Lys Arg Gly Leu Glu Trp Phe Val Cys Asp Gly Trp Lys Phe Leu Cys 
                85                  90                  95      


Thr Ser Cys Cys Gly Trp Leu Ile Asn Ile Cys Arg Arg Lys Lys Glu 
            100                 105                 110         


Leu Lys Ala Arg Thr Val Trp Leu Gly Cys Pro Glu Lys Cys Glu Glu 
        115                 120                 125             


Lys His Pro Arg Asn Ser Ile Lys Asn Gln Lys Tyr Asn Val Phe Thr 
    130                 135                 140                 


Phe Ile Pro Gly Val Leu Tyr Glu Gln Phe Lys Phe Phe Leu Asn Leu 
145                 150                 155                 160 


Tyr Phe Leu Val Ile Ser Cys Ser Gln Phe Val Pro Ala Leu Lys Ile 
                165                 170                 175     


Gly Tyr Leu Tyr Thr Tyr Trp Ala Pro Leu Gly Phe Val Leu Ala Val 
            180                 185                 190         


Thr Met Thr Arg Glu Ala Ile Asp Glu Phe Arg Arg Phe Gln Arg Asp 
        195                 200                 205             


Lys Glu Val Asn Ser Gln Leu Tyr Ser Lys Leu Thr Val Arg Gly Lys 
    210                 215                 220                 


Val Gln Val Lys Ser Ser Asp Ile Gln Val Gly Asp Leu Ile Ile Val 
225                 230                 235                 240 


Glu Lys Asn Gln Arg Ile Pro Ser Asp Met Val Phe Leu Arg Thr Ser 
                245                 250                 255     


Glu Lys Ala Gly Ser Cys Phe Ile Arg Thr Asp Gln Leu Asp Gly Glu 
            260                 265                 270         


Thr Asp Trp Lys Leu Lys Val Ala Val Ser Cys Thr Gln Gln Leu Pro 
        275                 280                 285             


Ala Leu Gly Asp Leu Phe Ser Ile Ser Ala Tyr Val Tyr Ala Gln Lys 
    290                 295                 300                 


Pro Gln Met Asp Ile His Ser Phe Glu Gly Thr Phe Thr Arg Glu Asp 
305                 310                 315                 320 


Ser Asp Pro Pro Ile His Glu Ser Leu Ser Ile Glu Asn Thr Leu Trp 
                325                 330                 335     


Ala Ser Thr Ile Val Ala Ser Gly Thr Val Ile Gly Val Val Ile Tyr 
            340                 345                 350         


Thr Gly Lys Glu Thr Arg Ser Val Met Asn Thr Ser Asn Pro Lys Asn 
        355                 360                 365             


Lys Val Gly Leu Leu Asp Leu Glu Leu Asn Arg Leu Thr Lys Ala Leu 
    370                 375                 380                 


Phe Leu Ala Leu Val Ala Leu Ser Ile Val Met Val Thr Leu Gln Gly 
385                 390                 395                 400 


Phe Val Gly Pro Trp Tyr Arg Asn Leu Phe Arg Phe Leu Leu Leu Phe 
                405                 410                 415     


Ser Tyr Ile Ile Pro Ile Ser Leu Arg Val Asn Leu Asp Met Gly Lys 
            420                 425                 430         


Ala Val Tyr Gly Trp Met Met Met Lys Asp Glu Asn Ile Pro Gly Thr 
        435                 440                 445             


Val Val Arg Thr Ser Thr Ile Pro Glu Glu Leu Gly Arg Leu Val Tyr 
    450                 455                 460                 


Leu Leu Thr Asp Lys Thr Gly Thr Leu Thr Gln Asn Glu Met Ile Phe 
465                 470                 475                 480 


Lys Arg Leu His Leu Gly Thr Val Ser Tyr Gly Ala Asp Thr Met Asp 
                485                 490                 495     


Glu Ile Gln Ser His Val Arg Asp Ser Tyr Ser Gln Met Gln Ser Gln 
            500                 505                 510         


Ala Gly Gly Asn Asn Thr Gly Ser Thr Pro Leu Arg Lys Ala Gln Ser 
        515                 520                 525             


Ser Ala Pro Lys Val Arg Lys Ser Val Ser Ser Arg Ile His Glu Ala 
    530                 535                 540                 


Val Lys Ala Ile Val Leu Cys His Asn Val Thr Pro Val Tyr Glu Ser 
545                 550                 555                 560 


Arg Ala Gly Val Thr Glu Glu Thr Glu Phe Ala Glu Ala Asp Gln Asp 
                565                 570                 575     


Phe Ser Asp Glu Asn Arg Thr Tyr Gln Ala Ser Ser Pro Asp Glu Val 
            580                 585                 590         


Ala Leu Val Gln Trp Thr Glu Ser Val Gly Leu Thr Leu Val Ser Arg 
        595                 600                 605             


Asp Leu Thr Ser Met Gln Leu Lys Thr Pro Ser Gly Gln Val Leu Ser 
    610                 615                 620                 


Phe Cys Ile Leu Gln Leu Phe Pro Phe Thr Ser Glu Ser Lys Arg Met 
625                 630                 635                 640 


Gly Val Ile Val Arg Asp Glu Ser Thr Ala Glu Ile Thr Phe Tyr Met 
                645                 650                 655     


Lys Gly Ala Asp Val Ala Met Ser Pro Ile Val Gln Tyr Asn Asp Trp 
            660                 665                 670         


Leu Glu Glu Glu Cys Gly Asn Met Ala Arg Glu Gly Leu Arg Thr Leu 
        675                 680                 685             


Val Val Ala Lys Lys Ala Leu Thr Glu Glu Gln Tyr Gln Asp Phe Glu 
    690                 695                 700                 


Ser Arg Tyr Thr Gln Ala Lys Leu Ser Met His Asp Arg Ser Leu Lys 
705                 710                 715                 720 


Val Ala Ala Val Val Glu Ser Leu Glu Arg Glu Met Glu Leu Leu Cys 
                725                 730                 735     


Leu Thr Gly Val Glu Asp Gln Leu Gln Ala Asp Val Arg Pro Thr Leu 
            740                 745                 750         


Glu Met Leu Arg Asn Ala Gly Ile Lys Ile Trp Met Leu Thr Gly Asp 
        755                 760                 765             


Lys Leu Glu Thr Ala Thr Cys Ile Ala Lys Ser Ser His Leu Val Ser 
    770                 775                 780                 


Arg Thr Gln Asp Ile His Ile Phe Arg Gln Val Thr Ser Arg Gly Glu 
785                 790                 795                 800 


Ala His Leu Glu Leu Asn Ala Phe Arg Arg Lys His Asp Cys Ala Leu 
                805                 810                 815     


Val Ile Ser Gly Asp Ser Leu Glu Val Cys Leu Lys Tyr Tyr Glu His 
            820                 825                 830         


Glu Phe Val Glu Leu Ala Cys Gln Cys Pro Ala Val Val Cys Cys Arg 
        835                 840                 845             


Cys Ser Pro Thr Gln Lys Ala Arg Ile Val Thr Leu Leu Gln Gln His 
    850                 855                 860                 


Thr Gly Arg Arg Thr Cys Ala Ile Gly Asp Gly Gly Asn Asp Val Ser 
865                 870                 875                 880 


Met Ile Gln Ala Ala Asp Cys Gly Ile Gly Ile Glu Gly Lys Glu Gly 
                885                 890                 895     


Lys Gln Ala Ser Leu Ala Ala Asp Phe Ser Ile Thr Gln Phe Arg His 
            900                 905                 910         


Ile Gly Arg Leu Leu Met Val His Gly Arg Asn Ser Tyr Lys Arg Ser 
        915                 920                 925             


Ala Ala Leu Gly Gln Phe Val Met His Arg Gly Leu Ile Ile Ser Thr 
    930                 935                 940                 


Met Gln Ala Val Phe Ser Ser Val Phe Tyr Phe Ala Ser Val Pro Leu 
945                 950                 955                 960 


Tyr Gln Gly Phe Leu Met Val Gly Tyr Ala Thr Ile Tyr Thr Met Phe 
                965                 970                 975     


Pro Val Phe Ser Leu Val Leu Asp Gln Asp Val Lys Pro Glu Met Ala 
            980                 985                 990         


Met Leu Tyr Pro Glu Leu Tyr Lys  Asp Leu Thr Lys Gly  Arg Ser Leu 
        995                 1000                 1005             


Ser Phe  Lys Thr Phe Leu Ile  Trp Val Leu Ile Ser  Ile Tyr Gln 
    1010                 1015                 1020             


Gly Gly  Ile Leu Met Tyr Gly  Ala Leu Val Leu Phe  Glu Ser Glu 
    1025                 1030                 1035             


Phe Val  His Val Val Ala Ile  Ser Phe Thr Ala Leu  Ile Leu Thr 
    1040                 1045                 1050             


Glu Leu  Leu Met Val Ala Leu  Thr Val Arg Thr Trp  His Trp Leu 
    1055                 1060                 1065             


Met Val  Val Ala Glu Phe Leu  Ser Leu Gly Cys Tyr  Val Ser Ser 
    1070                 1075                 1080             


Leu Ala  Phe Leu Asn Glu Tyr  Phe Gly Ile Gly Arg  Val Ser Phe 
    1085                 1090                 1095             


Gly Ala  Phe Leu Asp Val Ala  Phe Ile Thr Thr Val  Thr Phe Leu 
    1100                 1105                 1110             


Trp Lys  Val Ser Ala Ile Thr  Val Val Ser Cys Leu  Pro Leu Tyr 
    1115                 1120                 1125             


Val Leu  Lys Tyr Leu Arg Arg  Lys Leu Ser Pro Pro  Ser Tyr Cys 
    1130                 1135                 1140             


Lys Leu  Ala Ser 
    1145         


<210>  970
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATPAF2__Homo_sapiens__NP_663729

<400>  970

Met Trp Arg Ser Cys Leu Arg Leu Arg Asp Gly Gly Arg Arg Leu Leu 
1               5                   10                  15      


Asn Arg Pro Ala Gly Gly Pro Ser Ala Ser Met Ser Pro Gly Pro Thr 
            20                  25                  30          


Ile Pro Ser Pro Ala Arg Ala Tyr Ala Pro Pro Thr Glu Arg Lys Arg 
        35                  40                  45              


Phe Tyr Gln Asn Val Ser Ile Thr Gln Gly Glu Gly Gly Phe Glu Ile 
    50                  55                  60                  


Asn Leu Asp His Arg Lys Leu Lys Thr Pro Gln Ala Lys Leu Phe Thr 
65                  70                  75                  80  


Val Pro Ser Glu Ala Leu Ala Ile Ala Val Ala Thr Glu Trp Asp Ser 
                85                  90                  95      


Gln Gln Asp Thr Ile Lys Tyr Tyr Thr Met His Leu Thr Thr Leu Cys 
            100                 105                 110         


Asn Thr Ser Leu Asp Asn Pro Thr Gln Arg Asn Lys Asp Gln Leu Ile 
        115                 120                 125             


Arg Ala Ala Val Lys Phe Leu Asp Thr Asp Thr Ile Cys Tyr Arg Val 
    130                 135                 140                 


Glu Glu Pro Glu Thr Leu Val Glu Leu Gln Arg Asn Glu Trp Asp Pro 
145                 150                 155                 160 


Ile Ile Glu Trp Ala Glu Lys Arg Tyr Gly Val Glu Ile Ser Ser Ser 
                165                 170                 175     


Thr Ser Ile Met Gly Pro Ser Ile Pro Ala Lys Thr Arg Glu Val Leu 
            180                 185                 190         


Val Ser His Leu Ala Ser Tyr Asn Thr Trp Ala Leu Gln Gly Ile Glu 
        195                 200                 205             


Phe Val Ala Ala Gln Leu Lys Ser Met Val Leu Thr Leu Gly Leu Ile 
    210                 215                 220                 


Asp Leu Arg Leu Thr Val Glu Gln Ala Val Leu Leu Ser Arg Leu Glu 
225                 230                 235                 240 


Glu Glu Tyr Gln Ile Gln Lys Trp Gly Asn Ile Glu Trp Ala His Asp 
                245                 250                 255     


Tyr Glu Leu Gln Glu Leu Arg Ala Arg Thr Ala Ala Gly Thr Leu Phe 
            260                 265                 270         


Ile His Leu Cys Ser Glu Ser Thr Thr Val Lys His Lys Leu Leu Lys 
        275                 280                 285             


Glu 
    


<210>  971
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATRAID__Homo_sapiens__NP_001164266

<400>  971

Met Ala Pro His Asp Pro Gly Ser Leu Thr Thr Leu Val Pro Trp Ala 
1               5                   10                  15      


Ala Ala Leu Leu Leu Ala Leu Gly Val Glu Arg Ala Leu Ala Leu Pro 
            20                  25                  30          


Glu Ile Cys Thr Gln Cys Pro Gly Ser Val Gln Asn Leu Ser Lys Val 
        35                  40                  45              


Ala Phe Tyr Cys Lys Thr Thr Arg Glu Leu Met Leu His Ala Arg Cys 
    50                  55                  60                  


Cys Leu Asn Gln Lys Gly Thr Ile Leu Gly Leu Asp Leu Gln Asn Cys 
65                  70                  75                  80  


Ser Leu Glu Asp Pro Gly Pro Asn Phe His Gln Ala His Thr Thr Val 
                85                  90                  95      


Ile Ile Asp Leu Gln Ala Asn Pro Leu Lys Gly Asp Leu Ala Asn Thr 
            100                 105                 110         


Phe Arg Gly Phe Thr Gln Leu Gln Thr Leu Ile Leu Pro Gln His Val 
        115                 120                 125             


Asn Cys Pro Gly Gly Ile Asn Ala Trp Asn Thr Ile Thr Ser Tyr Ile 
    130                 135                 140                 


Asp Asn Gln Ile Cys Gln Gly Gln Lys Asn Leu Cys Asn Asn Thr Gly 
145                 150                 155                 160 


Asp Pro Glu Met Cys Pro Glu Asn Gly Ser Cys Val Pro Asp Gly Pro 
                165                 170                 175     


Gly Leu Leu Gln Cys Val Cys Ala Asp Gly Phe His Gly Tyr Lys Cys 
            180                 185                 190         


Met Arg Gln Gly Ser Phe Ser Leu Leu Met Phe Phe Gly Ile Leu Gly 
        195                 200                 205             


Ala Thr Thr Leu Ser Val Ser Ile Leu Leu Trp Ala Thr Gln Arg Arg 
    210                 215                 220                 


Lys Ala Lys Thr Ser 
225                 


<210>  972
<211>  2644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATR__Homo_sapiens__NP_001175

<400>  972

Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 
        195                 200                 205             


Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 
            980                 985                 990         


Arg Thr Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Thr Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Thr  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Thr Thr Leu Arg Thr  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Thr  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Thr  Ser Glu Ser 
    1265                 1270                 1275             


Thr Asp  Leu Gln Thr Thr Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Thr  Ser Leu Lys 
    1295                 1300                 1305             


Glu Thr  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Thr 
    1310                 1315                 1320             


Asp Ser  Glu Thr Val Glu Pro  Ile Ile Ser Gln Leu  Val Thr Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Thr Thr Glu  Thr Gln Gly Lys Asp  Phe Thr Phe 
    1370                 1375                 1380             


Val Thr  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Thr Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Thr  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Thr  Arg Tyr Lys Ser Ser  Gln Lys Ser Thr Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Thr  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Thr Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Thr  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Thr 
    1550                 1555                 1560             


Ile Asn  Thr Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Thr 
    1565                 1570                 1575             


Gln Thr  Val Phe Ser Met Leu  Asp His Leu Thr Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Thr  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Thr  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Thr  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Thr Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Thr Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Thr Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Thr Val Ile Thr Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Thr Asp Glu Leu  Asn Thr Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Thr Thr Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Thr Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Thr  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Thr Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Thr Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Thr 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Thr Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Thr Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Thr Leu Trp Leu  Asp Tyr Gly Thr Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Thr Glu His Thr  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Thr  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Thr  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Thr Arg Leu Thr Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Thr Leu Ser 
    2225                 2230                 2235             


Met Ser  Thr His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Thr Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Thr Leu  Pro Ser Ile Leu Gly  Thr His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Thr Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Thr Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Thr Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Thr Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Thr Phe Pro  Asp Pro Thr 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Thr Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Thr Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Thr Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Thr His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Thr Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Thr Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Thr Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Thr  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Thr  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Thr  Arg Asn Arg Val Thr  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Thr 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Thr Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210>  973
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATRIP__Homo_sapiens__NP_001257952

<400>  973

Met Ser Lys Asn Pro Ser Gly Lys Asn Arg Glu Thr Val Pro Ile Lys 
1               5                   10                  15      


Asp Asn Phe Glu Leu Glu Val Leu Gln Ala Gln Tyr Lys Glu Leu Lys 
            20                  25                  30          


Glu Lys Met Lys Val Met Glu Glu Glu Val Leu Ile Lys Asn Gly Glu 
        35                  40                  45              


Ile Lys Ile Leu Arg Asp Ser Leu His Gln Thr Glu Ser Val Leu Glu 
    50                  55                  60                  


Glu Gln Arg Arg Ser His Phe Leu Leu Glu Gln Glu Lys Thr Gln Ala 
65                  70                  75                  80  


Leu Ser Asp Lys Glu Lys Glu Phe Ser Lys Lys Leu Gln Ser Leu Gln 
                85                  90                  95      


Ser Glu Leu Gln Phe Lys Asp Ala Glu Met Asn Glu Leu Arg Thr Lys 
            100                 105                 110         


Leu Gln Thr Ser Glu Arg Ala Asn Lys Leu Ala Ala Pro Ser Val Ser 
        115                 120                 125             


His Val Ser Pro Arg Lys Asn Pro Ser Val Val Ile Lys Pro Glu Ala 
    130                 135                 140                 


Cys Ser Pro Gln Phe Gly Lys Thr Ser Phe Pro Thr Lys Glu Ser Phe 
145                 150                 155                 160 


Ser Ala Asn Met Ser Leu Pro His Pro Cys Gln Thr Glu Ser Gly Tyr 
                165                 170                 175     


Lys Pro Leu Val Gly Arg Glu Asp Ser Lys Pro His Ser Leu Arg Gly 
            180                 185                 190         


Asp Ser Ile Lys Gln Glu Glu Ala Gln Lys Ser Phe Val Asp Ser Trp 
        195                 200                 205             


Arg Gln Arg Ser Asn Thr Gln Gly Ser Ile Leu Ile Asn Leu Leu Leu 
    210                 215                 220                 


Lys Gln Pro Leu Ile Pro Gly Ser Ser Leu Ser Leu Cys His Leu Leu 
225                 230                 235                 240 


Ser Ser Ser Ser Glu Ser Pro Ala Gly Thr Pro Leu Gln Pro Pro Gly 
                245                 250                 255     


Phe Gly Ser Thr Leu Ala Gly Met Ser Gly Leu Arg Thr Thr Gly Ser 
            260                 265                 270         


Tyr Asp Gly Ser Phe Ser Leu Ser Ala Leu Arg Glu Ala Gln Asn Leu 
        275                 280                 285             


Ala Phe Thr Gly Leu Asn Leu Val Ala Arg Asn Glu Cys Ser Arg Asp 
    290                 295                 300                 


Gly Asp Pro Ala Glu Gly Gly Arg Arg Ala Phe Pro Leu Cys Gln Leu 
305                 310                 315                 320 


Pro Gly Ala Val His Phe Leu Pro Leu Val Gln Phe Phe Ile Gly Leu 
                325                 330                 335     


His Cys Gln Ala Leu Gln Asp Leu Ala Ala Ala Lys Arg Ser Gly Ala 
            340                 345                 350         


Pro Gly Asp Ser Pro Thr His Ser Ser Cys Val Ser Ser Gly Val Glu 
        355                 360                 365             


Thr Asn Pro Glu Asp Ser Val Cys Ile Leu Glu Gly Phe Ser Val Thr 
    370                 375                 380                 


Ala Leu Ser Ile Leu Gln His Leu Val Cys His Ser Gly Ala Val Val 
385                 390                 395                 400 


Ser Leu Leu Leu Ser Gly Val Gly Ala Asp Ser Ala Ala Gly Glu Gly 
                405                 410                 415     


Asn Arg Ser Leu Val His Arg Leu Ser Asp Gly Asp Met Thr Ser Ala 
            420                 425                 430         


Leu Arg Gly Val Ala Asp Asp Gln Gly Gln His Pro Leu Leu Lys Met 
        435                 440                 445             


Leu Leu His Leu Leu Ala Phe Ser Ser Ala Ala Thr Gly His Leu Gln 
    450                 455                 460                 


Ala Ser Val Leu Thr Gln Cys Leu Lys Val Leu Val Lys Leu Ala Glu 
465                 470                 475                 480 


Asn Thr Ser Cys Asp Phe Leu Pro Arg Phe Gln Cys Val Phe Gln Val 
                485                 490                 495     


Leu Pro Lys Cys Leu Ser Pro Glu Thr Pro Leu Pro Ser Val Leu Leu 
            500                 505                 510         


Ala Val Glu Leu Leu Ser Leu Leu Ala Asp His Asp Gln Leu Ala Pro 
        515                 520                 525             


Gln Leu Cys Ser His Ser Glu Gly Cys Leu Leu Leu Leu Leu Tyr Met 
    530                 535                 540                 


Tyr Ile Thr Ser Arg Pro Asp Arg Val Ala Leu Glu Thr Gln Trp Leu 
545                 550                 555                 560 


Gln Leu Glu Gln Glu Val Val Trp Leu Leu Ala Lys Leu Gly Val Gln 
                565                 570                 575     


Ser Pro Leu Pro Pro Val Thr Gly Ser Asn Cys Gln Cys Asn Val Glu 
            580                 585                 590         


Val Val Arg Ala Leu Thr Val Met Leu His Arg Gln Trp Leu Thr Val 
        595                 600                 605             


Arg Arg Ala Gly Gly Pro Pro Arg Thr Asp Gln Gln Arg Arg Thr Val 
    610                 615                 620                 


Arg Cys Leu Arg Asp Thr Val Leu Leu Leu His Gly Leu Ser Gln Lys 
625                 630                 635                 640 


Asp Lys Leu Phe Met Met His Cys Val Glu Val Leu His Gln Phe Asp 
                645                 650                 655     


Gln Val Met Pro Gly Val Ser Met Leu Ile Arg Gly Leu Pro Asp Val 
            660                 665                 670         


Thr Asp Cys Glu Glu Ala Ala Leu Asp Asp Leu Cys Ala Ala Glu Thr 
        675                 680                 685             


Asp Val Glu Asp Pro Glu Val Glu Cys Gly 
    690                 695             


<210>  974
<211>  1429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATRN__Homo_sapiens__NP_647537

<400>  974

Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr 
1               5                   10                  15      


Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp 
            20                  25                  30          


Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg 
        35                  40                  45              


Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu 
    50                  55                  60                  


Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala 
                85                  90                  95      


Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn 
            100                 105                 110         


Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln 
        115                 120                 125             


Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe 
    130                 135                 140                 


Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp 
145                 150                 155                 160 


Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His 
                165                 170                 175     


Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp 
            180                 185                 190         


Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro 
        195                 200                 205             


Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly 
    210                 215                 220                 


Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly 
225                 230                 235                 240 


Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly 
                245                 250                 255     


Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu 
            260                 265                 270         


Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr 
        275                 280                 285             


Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val 
    290                 295                 300                 


Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val 
305                 310                 315                 320 


Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn 
                325                 330                 335     


Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile 
            340                 345                 350         


Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met 
        355                 360                 365             


Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg 
    370                 375                 380                 


Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr 
385                 390                 395                 400 


Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn 
                405                 410                 415     


Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val 
            420                 425                 430         


Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser 
        435                 440                 445             


Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile 
    450                 455                 460                 


Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr 
465                 470                 475                 480 


Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu 
                485                 490                 495     


Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg 
            500                 505                 510         


Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr 
        515                 520                 525             


Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp 
    530                 535                 540                 


Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val 
545                 550                 555                 560 


Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp 
                565                 570                 575     


Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala 
            580                 585                 590         


Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu 
        595                 600                 605             


His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser 
    610                 615                 620                 


Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile 
625                 630                 635                 640 


Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala 
                645                 650                 655     


Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser 
            660                 665                 670         


Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys 
        675                 680                 685             


Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys 
    690                 695                 700                 


Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys 
705                 710                 715                 720 


His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu 
                725                 730                 735     


Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro 
            740                 745                 750         


Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp 
        755                 760                 765             


Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro 
    770                 775                 780                 


Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu 
785                 790                 795                 800 


Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys 
                805                 810                 815     


Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val 
            820                 825                 830         


Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met 
        835                 840                 845             


Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val 
    850                 855                 860                 


Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu 
865                 870                 875                 880 


Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu 
                885                 890                 895     


Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro 
            900                 905                 910         


Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln 
        915                 920                 925             


Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser 
    930                 935                 940                 


Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp 
945                 950                 955                 960 


Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp 
                965                 970                 975     


Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr 
            980                 985                 990         


Cys Ser His Cys Leu Glu Gln Pro  Gly Cys Gly Trp Cys  Thr Asp Pro 
        995                 1000                 1005             


Ser Asn  Thr Gly Lys Gly Lys  Cys Ile Glu Gly Ser  Tyr Lys Gly 
    1010                 1015                 1020             


Pro Val  Lys Met Pro Ser Gln  Ala Pro Thr Gly Asn  Phe Tyr Pro 
    1025                 1030                 1035             


Gln Pro  Leu Leu Asn Ser Ser  Met Cys Leu Glu Asp  Ser Arg Tyr 
    1040                 1045                 1050             


Asn Trp  Ser Phe Ile His Cys  Pro Ala Cys Gln Cys  Asn Gly His 
    1055                 1060                 1065             


Ser Lys  Cys Ile Asn Gln Ser  Ile Cys Glu Lys Cys  Glu Asn Leu 
    1070                 1075                 1080             


Thr Thr  Gly Lys His Cys Glu  Thr Cys Ile Ser Gly  Phe Tyr Gly 
    1085                 1090                 1095             


Asp Pro  Thr Asn Gly Gly Lys  Cys Gln Pro Cys Lys  Cys Asn Gly 
    1100                 1105                 1110             


His Ala  Ser Leu Cys Asn Thr  Asn Thr Gly Lys Cys  Phe Cys Thr 
    1115                 1120                 1125             


Thr Lys  Gly Val Lys Gly Asp  Glu Cys Gln Leu Cys  Glu Val Glu 
    1130                 1135                 1140             


Asn Arg  Tyr Gln Gly Asn Pro  Leu Arg Gly Thr Cys  Tyr Tyr Thr 
    1145                 1150                 1155             


Leu Leu  Ile Asp Tyr Gln Phe  Thr Phe Ser Leu Ser  Gln Glu Asp 
    1160                 1165                 1170             


Asp Arg  Tyr Tyr Thr Ala Ile  Asn Phe Val Ala Thr  Pro Asp Glu 
    1175                 1180                 1185             


Gln Asn  Arg Asp Leu Asp Met  Phe Ile Asn Ala Ser  Lys Asn Phe 
    1190                 1195                 1200             


Asn Leu  Asn Ile Thr Trp Ala  Ala Ser Phe Ser Ala  Gly Thr Gln 
    1205                 1210                 1215             


Ala Gly  Glu Glu Met Pro Val  Val Ser Lys Thr Asn  Ile Lys Glu 
    1220                 1225                 1230             


Tyr Lys  Asp Ser Phe Ser Asn  Glu Lys Phe Asp Phe  Arg Asn His 
    1235                 1240                 1245             


Pro Asn  Ile Thr Phe Phe Val  Tyr Val Ser Asn Phe  Thr Trp Pro 
    1250                 1255                 1260             


Ile Lys  Ile Gln Ile Ala Phe  Ser Gln His Ser Asn  Phe Met Asp 
    1265                 1270                 1275             


Leu Val  Gln Phe Phe Val Thr  Phe Phe Ser Cys Phe  Leu Ser Leu 
    1280                 1285                 1290             


Leu Leu  Val Ala Ala Val Val  Trp Lys Ile Lys Gln  Ser Cys Trp 
    1295                 1300                 1305             


Ala Ser  Arg Arg Arg Glu Gln  Leu Leu Arg Glu Met  Gln Gln Met 
    1310                 1315                 1320             


Ala Ser  Arg Pro Phe Ala Ser  Val Asn Val Ala Leu  Glu Thr Asp 
    1325                 1330                 1335             


Glu Glu  Pro Pro Asp Leu Ile  Gly Gly Ser Ile Lys  Thr Val Pro 
    1340                 1345                 1350             


Lys Pro  Ile Ala Leu Glu Pro  Cys Phe Gly Asn Lys  Ala Ala Val 
    1355                 1360                 1365             


Leu Ser  Val Phe Val Arg Leu  Pro Arg Gly Leu Gly  Gly Ile Pro 
    1370                 1375                 1380             


Pro Pro  Gly Gln Ser Gly Leu  Ala Val Ala Ser Ala  Leu Val Asp 
    1385                 1390                 1395             


Ile Ser  Gln Gln Met Pro Ile  Val Tyr Lys Glu Lys  Ser Gly Ala 
    1400                 1405                 1410             


Val Arg  Asn Arg Lys Gln Gln  Pro Pro Ala Gln Pro  Gly Thr Cys 
    1415                 1420                 1425             


Ile 
    


<210>  975
<211>  1379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATRNL1__Homo_sapiens__NP_997186

<400>  975

Met Glu Thr Gly Gly Arg Ala Arg Thr Gly Thr Pro Gln Pro Ala Ala 
1               5                   10                  15      


Pro Gly Val Trp Arg Ala Arg Pro Ala Gly Gly Gly Gly Gly Gly Ala 
            20                  25                  30          


Ser Ser Trp Leu Leu Asp Gly Asn Ser Trp Leu Leu Cys Tyr Gly Phe 
        35                  40                  45              


Leu Tyr Leu Ala Leu Tyr Ala Gln Val Ser Gln Ser Lys Pro Cys Glu 
    50                  55                  60                  


Arg Thr Gly Ser Cys Phe Ser Gly Arg Cys Val Asn Ser Thr Cys Leu 
65                  70                  75                  80  


Cys Asp Pro Gly Trp Val Gly Asp Gln Cys Gln His Cys Gln Gly Arg 
                85                  90                  95      


Phe Lys Leu Thr Glu Pro Ser Gly Tyr Leu Thr Asp Gly Pro Ile Asn 
            100                 105                 110         


Tyr Lys Tyr Lys Thr Lys Cys Thr Trp Leu Ile Glu Gly Tyr Pro Asn 
        115                 120                 125             


Ala Val Leu Arg Leu Arg Phe Asn His Phe Ala Thr Glu Cys Ser Trp 
    130                 135                 140                 


Asp His Met Tyr Val Tyr Asp Gly Asp Ser Ile Tyr Ala Pro Leu Ile 
145                 150                 155                 160 


Ala Val Leu Ser Gly Leu Ile Val Pro Glu Ile Arg Gly Asn Glu Thr 
                165                 170                 175     


Val Pro Glu Val Val Thr Thr Ser Gly Tyr Ala Leu Leu His Phe Phe 
            180                 185                 190         


Ser Asp Ala Ala Tyr Asn Leu Thr Gly Phe Asn Ile Phe Tyr Ser Ile 
        195                 200                 205             


Asn Ser Cys Pro Asn Asn Cys Ser Gly His Gly Lys Cys Thr Thr Ser 
    210                 215                 220                 


Val Ser Val Pro Ser Gln Val Tyr Cys Glu Cys Asp Lys Tyr Trp Lys 
225                 230                 235                 240 


Gly Glu Ala Cys Asp Ile Pro Tyr Cys Lys Ala Asn Cys Gly Ser Pro 
                245                 250                 255     


Asp His Gly Tyr Cys Asp Leu Thr Gly Glu Lys Leu Cys Val Cys Asn 
            260                 265                 270         


Asp Ser Trp Gln Gly Pro Asp Cys Ser Leu Asn Val Pro Ser Thr Glu 
        275                 280                 285             


Ser Tyr Trp Ile Leu Pro Asn Val Lys Pro Phe Ser Pro Ser Val Gly 
    290                 295                 300                 


Arg Ala Ser His Lys Ala Val Leu His Gly Lys Phe Met Trp Val Ile 
305                 310                 315                 320 


Gly Gly Tyr Thr Phe Asn Tyr Ser Ser Phe Gln Met Val Leu Asn Tyr 
                325                 330                 335     


Asn Leu Glu Ser Ser Ile Trp Asn Val Gly Thr Pro Ser Arg Gly Pro 
            340                 345                 350         


Leu Gln Arg Tyr Gly His Ser Leu Ala Leu Tyr Gln Glu Asn Ile Phe 
        355                 360                 365             


Met Tyr Gly Gly Arg Ile Glu Thr Asn Asp Gly Asn Val Thr Asp Glu 
    370                 375                 380                 


Leu Trp Val Phe Asn Ile His Ser Gln Ser Trp Ser Thr Lys Thr Pro 
385                 390                 395                 400 


Thr Val Leu Gly His Gly Gln Gln Tyr Ala Val Glu Gly His Ser Ala 
                405                 410                 415     


His Ile Met Glu Leu Asp Ser Arg Asp Val Val Met Ile Ile Ile Phe 
            420                 425                 430         


Gly Tyr Ser Ala Ile Tyr Gly Tyr Thr Ser Ser Ile Gln Glu Tyr His 
        435                 440                 445             


Ile Ser Ser Asn Thr Trp Leu Val Pro Glu Thr Lys Gly Ala Ile Val 
    450                 455                 460                 


Gln Gly Gly Tyr Gly His Thr Ser Val Tyr Asp Glu Ile Thr Lys Ser 
465                 470                 475                 480 


Ile Tyr Val His Gly Gly Tyr Lys Ala Leu Pro Gly Asn Lys Tyr Gly 
                485                 490                 495     


Leu Val Asp Asp Leu Tyr Lys Tyr Glu Val Asn Thr Lys Thr Trp Thr 
            500                 505                 510         


Ile Leu Lys Glu Ser Gly Phe Ala Arg Tyr Leu His Ser Ala Val Leu 
        515                 520                 525             


Ile Asn Gly Ala Met Leu Ile Phe Gly Gly Asn Thr His Asn Asp Thr 
    530                 535                 540                 


Ser Leu Ser Asn Gly Ala Lys Cys Phe Ser Ala Asp Phe Leu Ala Tyr 
545                 550                 555                 560 


Asp Ile Ala Cys Asp Glu Trp Lys Ile Leu Pro Lys Pro Asn Leu His 
                565                 570                 575     


Arg Asp Val Asn Arg Phe Gly His Ser Ala Val Val Ile Asn Gly Ser 
            580                 585                 590         


Met Tyr Ile Phe Gly Gly Phe Ser Ser Val Leu Leu Asn Asp Ile Leu 
        595                 600                 605             


Val Tyr Lys Pro Pro Asn Cys Lys Ala Phe Arg Asp Glu Glu Leu Cys 
    610                 615                 620                 


Lys Asn Ala Gly Pro Gly Ile Lys Cys Val Trp Asn Lys Asn His Cys 
625                 630                 635                 640 


Glu Ser Trp Glu Ser Gly Asn Thr Asn Asn Ile Leu Arg Ala Lys Cys 
                645                 650                 655     


Pro Pro Lys Thr Ala Ala Ser Asp Asp Arg Cys Tyr Arg Tyr Ala Asp 
            660                 665                 670         


Cys Ala Ser Cys Thr Ala Asn Thr Asn Gly Cys Gln Trp Cys Asp Asp 
        675                 680                 685             


Lys Lys Cys Ile Ser Ala Asn Ser Asn Cys Ser Met Ser Val Lys Asn 
    690                 695                 700                 


Tyr Thr Lys Cys His Val Arg Asn Glu Gln Ile Cys Asn Lys Leu Thr 
705                 710                 715                 720 


Ser Cys Lys Ser Cys Ser Leu Asn Leu Asn Cys Gln Trp Asp Gln Arg 
                725                 730                 735     


Gln Gln Glu Cys Gln Ala Leu Pro Ala His Leu Cys Gly Glu Gly Trp 
            740                 745                 750         


Ser His Ile Gly Asp Ala Cys Leu Arg Val Asn Ser Ser Arg Glu Asn 
        755                 760                 765             


Tyr Asp Asn Ala Lys Leu Tyr Cys Tyr Asn Leu Ser Gly Asn Leu Ala 
    770                 775                 780                 


Ser Leu Thr Thr Ser Lys Glu Val Glu Phe Val Leu Asp Glu Ile Gln 
785                 790                 795                 800 


Lys Tyr Thr Gln Gln Lys Val Ser Pro Trp Val Gly Leu Arg Lys Ile 
                805                 810                 815     


Asn Ile Ser Tyr Trp Gly Trp Glu Asp Met Ser Pro Phe Thr Asn Thr 
            820                 825                 830         


Thr Leu Gln Trp Leu Pro Gly Glu Pro Asn Asp Ser Gly Phe Cys Ala 
        835                 840                 845             


Tyr Leu Glu Arg Ala Ala Val Ala Gly Leu Lys Ala Asn Pro Cys Thr 
    850                 855                 860                 


Ser Met Ala Asn Gly Leu Val Cys Glu Lys Pro Val Val Ser Pro Asn 
865                 870                 875                 880 


Gln Asn Ala Arg Pro Cys Lys Lys Pro Cys Ser Leu Arg Thr Ser Cys 
                885                 890                 895     


Ser Asn Cys Thr Ser Asn Gly Met Glu Cys Met Trp Cys Ser Ser Thr 
            900                 905                 910         


Lys Arg Cys Val Asp Ser Asn Ala Tyr Ile Ile Ser Phe Pro Tyr Gly 
        915                 920                 925             


Gln Cys Leu Glu Trp Gln Thr Ala Thr Cys Ser Pro Gln Asn Cys Ser 
    930                 935                 940                 


Gly Leu Arg Thr Cys Gly Gln Cys Leu Glu Gln Pro Gly Cys Gly Trp 
945                 950                 955                 960 


Cys Asn Asp Pro Ser Asn Thr Gly Arg Gly His Cys Ile Glu Gly Ser 
                965                 970                 975     


Ser Arg Gly Pro Met Lys Leu Ile Gly Met His His Ser Glu Met Val 
            980                 985                 990         


Leu Asp Thr Asn Leu Cys Pro Lys  Glu Lys Asn Tyr Glu  Trp Ser Phe 
        995                 1000                 1005             


Ile Gln  Cys Pro Ala Cys Gln  Cys Asn Gly His Ser  Thr Cys Ile 
    1010                 1015                 1020             


Asn Asn  Asn Val Cys Glu Gln  Cys Lys Asn Leu Thr  Thr Gly Lys 
    1025                 1030                 1035             


Gln Cys  Gln Asp Cys Met Pro  Gly Tyr Tyr Gly Asp  Pro Thr Asn 
    1040                 1045                 1050             


Gly Gly  Gln Cys Thr Ala Cys  Thr Cys Ser Gly His  Ala Asn Ile 
    1055                 1060                 1065             


Cys His  Leu His Thr Gly Lys  Cys Phe Cys Thr Thr  Lys Gly Ile 
    1070                 1075                 1080             


Lys Gly  Asp Gln Cys Gln Leu  Cys Asp Ser Glu Asn  Arg Tyr Val 
    1085                 1090                 1095             


Gly Asn  Pro Leu Arg Gly Thr  Cys Tyr Tyr Ser Leu  Leu Ile Asp 
    1100                 1105                 1110             


Tyr Gln  Phe Thr Phe Ser Leu  Leu Gln Glu Asp Asp  Arg His His 
    1115                 1120                 1125             


Thr Ala  Ile Asn Phe Ile Ala  Asn Pro Glu Gln Ser  Asn Lys Asn 
    1130                 1135                 1140             


Leu Asp  Ile Ser Ile Asn Ala  Ser Asn Asn Phe Asn  Leu Asn Ile 
    1145                 1150                 1155             


Thr Trp  Ser Val Gly Ser Thr  Ala Gly Thr Ile Ser  Gly Glu Glu 
    1160                 1165                 1170             


Thr Ser  Ile Val Ser Lys Asn  Asn Ile Lys Glu Tyr  Arg Asp Ser 
    1175                 1180                 1185             


Phe Ser  Tyr Glu Lys Phe Asn  Phe Arg Ser Asn Pro  Asn Ile Thr 
    1190                 1195                 1200             


Phe Tyr  Val Tyr Val Ser Asn  Phe Ser Trp Pro Ile  Lys Ile Gln 
    1205                 1210                 1215             


Ile Ala  Phe Ser Gln His Asn  Thr Ile Met Asp Leu  Val Gln Phe 
    1220                 1225                 1230             


Phe Val  Thr Phe Phe Ser Cys  Phe Leu Ser Leu Leu  Leu Val Ala 
    1235                 1240                 1245             


Ala Val  Val Trp Lys Ile Lys  Gln Thr Cys Trp Ala  Ser Arg Arg 
    1250                 1255                 1260             


Arg Glu  Gln Leu Leu Arg Glu  Arg Gln Gln Met Ala  Ser Arg Pro 
    1265                 1270                 1275             


Phe Ala  Ser Val Asp Val Ala  Leu Glu Val Gly Ala  Glu Gln Thr 
    1280                 1285                 1290             


Glu Phe  Leu Arg Gly Pro Leu  Glu Gly Ala Pro Lys  Pro Ile Ala 
    1295                 1300                 1305             


Ile Glu  Pro Cys Ala Gly Asn  Arg Ala Ala Val Leu  Thr Val Phe 
    1310                 1315                 1320             


Leu Cys  Leu Pro Arg Gly Ser  Ser Gly Ala Pro Pro  Pro Gly Gln 
    1325                 1330                 1335             


Ser Gly  Leu Ala Ile Ala Ser  Ala Leu Ile Asp Ile  Ser Gln Gln 
    1340                 1345                 1350             


Lys Ala  Ser Asp Ser Lys Asp  Lys Thr Ser Gly Val  Arg Asn Arg 
    1355                 1360                 1365             


Lys His  Leu Ser Thr Arg Gln  Gly Thr Cys Val 
    1370                 1375                 


<210>  976
<211>  2492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATRX__Homo_sapiens__NP_000480

<400>  976

Met Thr Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Thr Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Thr 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Thr Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Thr Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Thr Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Thr Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Thr Met Gln Ser Leu Pro Lys Gly Thr Val Ile Val 
        115                 120                 125             


Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro 
    130                 135                 140                 


Glu Phe Arg Ser Arg Ser Lys Met Lys Thr Glu Asn Leu Lys Lys Arg 
145                 150                 155                 160 


Gly Glu Asp Gly Leu His Gly Ile Val Ser Cys Thr Ala Cys Gly Gln 
                165                 170                 175     


Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His Pro Ser Leu 
            180                 185                 190         


Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp 
        195                 200                 205             


Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys Arg Trp Cys Ala 
    210                 215                 220                 


Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His Asn Ala Phe Cys 
225                 230                 235                 240 


Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu Leu Ser Thr Ile 
                245                 250                 255     


Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro 
            260                 265                 270         


Leu Leu Asp Leu Val Thr Ala Cys Asn Ser Val Phe Glu Asn Leu Glu 
        275                 280                 285             


Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys Val Asp Ser Glu Lys 
    290                 295                 300                 


Ser Asn Lys Val Tyr Glu His Thr Ser Arg Phe Ser Pro Lys Lys Thr 
305                 310                 315                 320 


Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser 
                325                 330                 335     


Gly Ser Val Thr Tyr Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu Met 
            340                 345                 350         


Ile Lys Lys Ala Lys Lys Leu Ile Glu Thr Thr Ala Asn Met Asn Ser 
        355                 360                 365             


Ser Tyr Val Lys Phe Leu Lys Gln Ala Thr Asp Asn Ser Glu Ile Ser 
    370                 375                 380                 


Ser Ala Thr Lys Leu Arg Gln Leu Lys Ala Phe Lys Ser Val Leu Ala 
385                 390                 395                 400 


Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu 
                405                 410                 415     


Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys Asn Thr Lys Glu His 
            420                 425                 430         


Lys Val Ile Asp Ala Lys Phe Glu Thr Lys Ala Arg Lys Gly Glu Lys 
        435                 440                 445             


Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu 
    450                 455                 460                 


Ser Arg Lys Gln Val Asp Ser Glu His Met His Gln Asn Val Pro Thr 
465                 470                 475                 480 


Glu Glu Gln Arg Thr Asn Lys Ser Thr Gly Gly Glu His Lys Lys Ser 
                485                 490                 495     


Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala Asn Thr Ser Glu Asp 
            500                 505                 510         


Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser Val Pro Glu Asp Ile 
        515                 520                 525             


Phe Glu Asn Leu Glu Thr Ala Met Glu Val Gln Ser Ser Val Asp His 
    530                 535                 540                 


Gln Gly Asp Gly Ser Ser Gly Thr Glu Gln Glu Val Glu Ser Ser Ser 
545                 550                 555                 560 


Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser 
                565                 570                 575     


Lys Thr Thr Ala Lys Val Thr Lys Glu Leu Tyr Val Lys Leu Thr Pro 
            580                 585                 590         


Val Ser Leu Ser Asn Ser Pro Ile Lys Gly Ala Asp Cys Gln Glu Val 
        595                 600                 605             


Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu 
    610                 615                 620                 


Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp Asn Glu His Leu Val 
625                 630                 635                 640 


Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser 
                645                 650                 655     


Pro Arg Val Lys Thr Thr Pro Leu Arg Arg Pro Thr Glu Thr Asn Pro 
            660                 665                 670         


Val Thr Ser Asn Ser Asp Glu Glu Cys Asn Glu Thr Val Lys Glu Lys 
        675                 680                 685             


Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp Lys Arg Asn Ser Ser 
    690                 695                 700                 


Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys 
705                 710                 715                 720 


Gln Ser Glu Thr Val Asp Gln Asn Ser Asp Ser Asp Glu Met Leu Ala 
                725                 730                 735     


Ile Leu Lys Glu Val Ser Arg Met Ser His Ser Ser Ser Ser Asp Thr 
            740                 745                 750         


Asp Ile Asn Glu Ile His Thr Asn His Lys Thr Leu Tyr Asp Leu Lys 
        755                 760                 765             


Thr Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser 
    770                 775                 780                 


Thr Ser Gly Ser Asp Phe Asp Thr Lys Lys Gly Lys Ser Ala Lys Ser 
785                 790                 795                 800 


Ser Ile Ile Ser Lys Lys Lys Arg Gln Thr Gln Ser Glu Ser Ser Asn 
                805                 810                 815     


Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser Met Ser Lys Ile Gly 
            820                 825                 830         


Ala Ala Arg Thr Thr Lys Lys Arg Ile Pro Asn Thr Lys Asp Phe Asp 
        835                 840                 845             


Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly Met Asp Asn Gln Gly 
    850                 855                 860                 


His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu 
865                 870                 875                 880 


Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala Glu Gly Thr Val Asp 
                885                 890                 895     


Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln 
            900                 905                 910         


Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys Leu Ser Gly Lys Glu 
        915                 920                 925             


Glu Ser Phe Thr Ser Leu Glu Val Arg Lys Val Ala Glu Thr Lys Glu 
    930                 935                 940                 


Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys Lys Val Gln Asp Gly 
945                 950                 955                 960 


Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu 
                965                 970                 975     


Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys Gly Thr Glu Glu Lys 
            980                 985                 990         


Lys Lys Pro Ser Asp Phe Lys Lys  Lys Val Ile Lys Met  Glu Gln Gln 
        995                 1000                 1005             


Tyr Glu  Ser Ser Ser Asp Gly  Thr Glu Lys Leu Pro  Glu Arg Glu 
    1010                 1015                 1020             


Glu Ile  Cys His Phe Pro Lys  Gly Ile Lys Gln Ile  Lys Asn Gly 
    1025                 1030                 1035             


Thr Thr  Asp Gly Glu Lys Lys  Ser Lys Lys Ile Arg  Asp Lys Thr 
    1040                 1045                 1050             


Ser Lys  Lys Lys Asp Glu Leu  Ser Asp Tyr Ala Glu  Lys Ser Thr 
    1055                 1060                 1065             


Gly Lys  Gly Asp Ser Cys Asp  Ser Ser Glu Asp Lys  Lys Ser Lys 
    1070                 1075                 1080             


Asn Gly  Ala Tyr Gly Arg Glu  Lys Lys Arg Cys Lys  Leu Leu Gly 
    1085                 1090                 1095             


Lys Ser  Ser Arg Lys Arg Gln  Asp Cys Ser Ser Ser  Asp Thr Glu 
    1100                 1105                 1110             


Lys Tyr  Ser Met Lys Glu Asp  Gly Cys Asn Ser Ser  Asp Lys Arg 
    1115                 1120                 1125             


Leu Lys  Arg Ile Glu Leu Arg  Glu Arg Arg Asn Leu  Ser Ser Lys 
    1130                 1135                 1140             


Arg Asn  Thr Lys Glu Ile Gln  Ser Gly Ser Ser Ser  Ser Asp Ala 
    1145                 1150                 1155             


Glu Glu  Ser Ser Glu Asp Asn  Lys Lys Lys Lys Gln  Arg Thr Ser 
    1160                 1165                 1170             


Ser Lys  Lys Lys Ala Val Ile  Val Lys Glu Lys Lys  Arg Asn Ser 
    1175                 1180                 1185             


Leu Arg  Thr Ser Thr Lys Arg  Lys Gln Ala Asp Ile  Thr Ser Ser 
    1190                 1195                 1200             


Ser Ser  Ser Asp Ile Glu Asp  Asp Asp Gln Asn Ser  Ile Gly Glu 
    1205                 1210                 1215             


Gly Ser  Ser Asp Glu Gln Lys  Ile Lys Pro Val Thr  Glu Asn Leu 
    1220                 1225                 1230             


Val Leu  Ser Ser His Thr Gly  Phe Cys Gln Ser Ser  Gly Asp Glu 
    1235                 1240                 1245             


Ala Leu  Ser Lys Ser Val Pro  Val Thr Val Asp Asp  Asp Asp Asp 
    1250                 1255                 1260             


Asp Asn  Asp Pro Glu Asn Arg  Ile Ala Lys Lys Met  Leu Leu Glu 
    1265                 1270                 1275             


Glu Ile  Lys Ala Asn Leu Ser  Ser Asp Glu Asp Gly  Ser Ser Asp 
    1280                 1285                 1290             


Asp Glu  Pro Glu Glu Gly Lys  Lys Arg Thr Gly Lys  Gln Asn Glu 
    1295                 1300                 1305             


Glu Asn  Pro Gly Asp Glu Glu  Ala Lys Asn Gln Val  Asn Ser Glu 
    1310                 1315                 1320             


Ser Asp  Ser Asp Ser Glu Glu  Ser Lys Lys Pro Arg  Tyr Arg His 
    1325                 1330                 1335             


Arg Leu  Leu Arg His Lys Leu  Thr Val Ser Asp Gly  Glu Ser Gly 
    1340                 1345                 1350             


Glu Glu  Lys Lys Thr Lys Pro  Lys Glu His Lys Glu  Val Lys Gly 
    1355                 1360                 1365             


Arg Asn  Arg Arg Lys Val Ser  Ser Glu Asp Ser Glu  Asp Ser Asp 
    1370                 1375                 1380             


Phe Gln  Glu Ser Gly Val Ser  Glu Glu Val Ser Glu  Ser Glu Asp 
    1385                 1390                 1395             


Glu Gln  Arg Pro Arg Thr Arg  Ser Ala Lys Lys Ala  Glu Leu Glu 
    1400                 1405                 1410             


Glu Asn  Gln Arg Ser Tyr Lys  Gln Lys Lys Lys Arg  Arg Arg Ile 
    1415                 1420                 1425             


Lys Val  Gln Glu Asp Ser Ser  Ser Glu Asn Lys Ser  Asn Ser Glu 
    1430                 1435                 1440             


Glu Glu  Glu Glu Glu Lys Glu  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Glu Glu Glu Glu Asp  Glu Asn Asp Asp Ser  Lys Ser Pro 
    1460                 1465                 1470             


Gly Lys  Gly Arg Lys Lys Ile  Arg Lys Ile Leu Lys  Asp Asp Lys 
    1475                 1480                 1485             


Leu Arg  Thr Glu Thr Gln Asn  Ala Leu Lys Glu Glu  Glu Glu Arg 
    1490                 1495                 1500             


Arg Lys  Arg Ile Ala Glu Arg  Glu Arg Glu Arg Glu  Lys Leu Arg 
    1505                 1510                 1515             


Glu Val  Ile Glu Ile Glu Asp  Ala Ser Pro Thr Lys  Cys Pro Ile 
    1520                 1525                 1530             


Thr Thr  Lys Leu Val Leu Asp  Glu Asp Glu Glu Thr  Lys Glu Pro 
    1535                 1540                 1545             


Leu Val  Gln Val His Arg Asn  Met Val Ile Lys Leu  Lys Pro His 
    1550                 1555                 1560             


Gln Val  Asp Gly Val Gln Phe  Met Trp Asp Cys Cys  Cys Glu Ser 
    1565                 1570                 1575             


Val Lys  Lys Thr Lys Lys Ser  Pro Gly Ser Gly Cys  Ile Leu Ala 
    1580                 1585                 1590             


His Cys  Met Gly Leu Gly Lys  Thr Leu Gln Val Val  Ser Phe Leu 
    1595                 1600                 1605             


His Thr  Val Leu Leu Cys Asp  Lys Leu Asp Phe Ser  Thr Ala Leu 
    1610                 1615                 1620             


Val Val  Cys Pro Leu Asn Thr  Ala Leu Asn Trp Met  Asn Glu Phe 
    1625                 1630                 1635             


Glu Lys  Trp Gln Glu Gly Leu  Lys Asp Asp Glu Lys  Leu Glu Val 
    1640                 1645                 1650             


Ser Glu  Leu Ala Thr Val Lys  Arg Pro Gln Glu Arg  Ser Tyr Met 
    1655                 1660                 1665             


Leu Gln  Arg Trp Gln Glu Asp  Gly Gly Val Met Ile  Ile Gly Tyr 
    1670                 1675                 1680             


Glu Met  Tyr Arg Asn Leu Ala  Gln Gly Arg Asn Val  Lys Ser Arg 
    1685                 1690                 1695             


Lys Leu  Lys Glu Ile Phe Asn  Lys Ala Leu Val Asp  Pro Gly Pro 
    1700                 1705                 1710             


Asp Phe  Val Val Cys Asp Glu  Gly His Ile Leu Lys  Asn Glu Ala 
    1715                 1720                 1725             


Ser Ala  Val Ser Lys Ala Met  Asn Ser Ile Arg Ser  Arg Arg Arg 
    1730                 1735                 1740             


Ile Ile  Leu Thr Gly Thr Pro  Leu Gln Asn Asn Leu  Ile Glu Tyr 
    1745                 1750                 1755             


His Cys  Met Val Asn Phe Ile  Lys Glu Asn Leu Leu  Gly Ser Ile 
    1760                 1765                 1770             


Lys Glu  Phe Arg Asn Arg Phe  Ile Asn Pro Ile Gln  Asn Gly Gln 
    1775                 1780                 1785             


Cys Ala  Asp Ser Thr Met Val  Asp Val Arg Val Met  Lys Lys Arg 
    1790                 1795                 1800             


Ala His  Ile Leu Tyr Glu Met  Leu Ala Gly Cys Val  Gln Arg Lys 
    1805                 1810                 1815             


Asp Tyr  Thr Ala Leu Thr Lys  Phe Leu Pro Pro Lys  His Glu Tyr 
    1820                 1825                 1830             


Val Leu  Ala Val Arg Met Thr  Ser Ile Gln Cys Lys  Leu Tyr Gln 
    1835                 1840                 1845             


Tyr Tyr  Leu Asp His Leu Thr  Gly Val Gly Asn Asn  Ser Glu Gly 
    1850                 1855                 1860             


Gly Arg  Gly Lys Ala Gly Ala  Lys Leu Phe Gln Asp  Phe Gln Met 
    1865                 1870                 1875             


Leu Ser  Arg Ile Trp Thr His  Pro Trp Cys Leu Gln  Leu Asp Tyr 
    1880                 1885                 1890             


Ile Ser  Lys Glu Asn Lys Gly  Tyr Phe Asp Glu Asp  Ser Met Asp 
    1895                 1900                 1905             


Glu Phe  Ile Ala Ser Asp Ser  Asp Glu Thr Ser Met  Ser Leu Ser 
    1910                 1915                 1920             


Ser Asp  Asp Tyr Thr Lys Lys  Lys Lys Lys Gly Lys  Lys Gly Lys 
    1925                 1930                 1935             


Lys Asp  Ser Ser Ser Ser Gly  Ser Gly Ser Asp Asn  Asp Val Glu 
    1940                 1945                 1950             


Val Ile  Lys Val Trp Asn Ser  Arg Ser Arg Gly Gly  Gly Glu Gly 
    1955                 1960                 1965             


Asn Val  Asp Glu Thr Gly Asn  Asn Pro Ser Val Ser  Leu Lys Leu 
    1970                 1975                 1980             


Glu Glu  Ser Lys Ala Thr Ser  Ser Ser Asn Pro Ser  Ser Pro Ala 
    1985                 1990                 1995             


Pro Asp  Trp Tyr Lys Asp Phe  Val Thr Asp Ala Asp  Ala Glu Val 
    2000                 2005                 2010             


Leu Glu  His Ser Gly Lys Met  Val Leu Leu Phe Glu  Ile Leu Arg 
    2015                 2020                 2025             


Met Ala  Glu Glu Ile Gly Asp  Lys Val Leu Val Phe  Ser Gln Ser 
    2030                 2035                 2040             


Leu Ile  Ser Leu Asp Leu Ile  Glu Asp Phe Leu Glu  Leu Ala Ser 
    2045                 2050                 2055             


Arg Glu  Lys Thr Glu Asp Lys  Asp Lys Pro Leu Ile  Tyr Lys Gly 
    2060                 2065                 2070             


Glu Gly  Lys Trp Leu Arg Asn  Ile Asp Tyr Tyr Arg  Leu Asp Gly 
    2075                 2080                 2085             


Ser Thr  Thr Ala Gln Ser Arg  Lys Lys Trp Ala Glu  Glu Phe Asn 
    2090                 2095                 2100             


Asp Glu  Thr Asn Val Arg Gly  Arg Leu Phe Ile Ile  Ser Thr Lys 
    2105                 2110                 2115             


Ala Gly  Ser Leu Gly Ile Asn  Leu Val Ala Ala Asn  Arg Val Ile 
    2120                 2125                 2130             


Ile Phe  Asp Ala Ser Trp Asn  Pro Ser Tyr Asp Ile  Gln Ser Ile 
    2135                 2140                 2145             


Phe Arg  Val Tyr Arg Phe Gly  Gln Thr Lys Pro Val  Tyr Val Tyr 
    2150                 2155                 2160             


Arg Phe  Leu Ala Gln Gly Thr  Met Glu Asp Lys Ile  Tyr Asp Arg 
    2165                 2170                 2175             


Gln Val  Thr Lys Gln Ser Leu  Ser Phe Arg Val Val  Asp Gln Gln 
    2180                 2185                 2190             


Gln Val  Glu Arg His Phe Thr  Met Asn Glu Leu Thr  Glu Leu Tyr 
    2195                 2200                 2205             


Thr Phe  Glu Pro Asp Leu Leu  Asp Asp Pro Asn Ser  Glu Lys Lys 
    2210                 2215                 2220             


Lys Lys  Arg Asp Thr Pro Met  Leu Pro Lys Asp Thr  Ile Leu Ala 
    2225                 2230                 2235             


Glu Leu  Leu Gln Ile His Lys  Glu His Ile Val Gly  Tyr His Glu 
    2240                 2245                 2250             


His Asp  Ser Leu Leu Asp His  Lys Glu Glu Glu Glu  Leu Thr Glu 
    2255                 2260                 2265             


Glu Glu  Arg Lys Ala Ala Trp  Ala Glu Tyr Glu Ala  Glu Lys Lys 
    2270                 2275                 2280             


Gly Leu  Thr Met Arg Phe Asn  Ile Pro Thr Gly Thr  Asn Leu Pro 
    2285                 2290                 2295             


Pro Val  Ser Phe Asn Ser Gln  Thr Pro Tyr Ile Pro  Phe Asn Leu 
    2300                 2305                 2310             


Gly Ala  Leu Ser Ala Met Ser  Asn Gln Gln Leu Glu  Asp Leu Ile 
    2315                 2320                 2325             


Asn Gln  Gly Arg Glu Lys Val  Val Glu Ala Thr Asn  Ser Val Thr 
    2330                 2335                 2340             


Ala Val  Arg Ile Gln Pro Leu  Glu Asp Ile Ile Ser  Ala Val Trp 
    2345                 2350                 2355             


Lys Glu  Asn Met Asn Leu Ser  Glu Ala Gln Val Gln  Ala Leu Ala 
    2360                 2365                 2370             


Leu Ser  Arg Gln Ala Ser Gln  Glu Leu Asp Val Lys  Arg Arg Glu 
    2375                 2380                 2385             


Ala Ile  Tyr Asn Asp Val Leu  Thr Lys Gln Gln Met  Leu Ile Ser 
    2390                 2395                 2400             


Cys Val  Gln Arg Ile Leu Met  Asn Arg Arg Leu Gln  Gln Gln Tyr 
    2405                 2410                 2415             


Asn Gln  Gln Gln Gln Gln Gln  Met Thr Tyr Gln Gln  Ala Thr Leu 
    2420                 2425                 2430             


Gly His  Leu Met Met Pro Lys  Pro Pro Asn Leu Ile  Met Asn Pro 
    2435                 2440                 2445             


Ser Asn  Tyr Gln Gln Ile Asp  Met Arg Gly Met Tyr  Gln Pro Val 
    2450                 2455                 2460             


Ala Gly  Gly Met Gln Pro Pro  Pro Leu Gln Arg Ala  Pro Pro Pro 
    2465                 2470                 2475             


Met Arg  Ser Lys Asn Pro Gly  Pro Ser Gln Gly Lys  Ser Met 
    2480                 2485                 2490         


<210>  977
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN10__Homo_sapiens__NP_001161093

<400>  977

Met Ala Ala Pro Arg Pro Pro Pro Ala Arg Leu Ser Gly Val Met Val 
1               5                   10                  15      


Pro Ala Pro Ile Gln Asp Leu Glu Ala Leu Arg Ala Leu Thr Ala Leu 
            20                  25                  30          


Phe Lys Glu Gln Arg Asn Arg Asn Leu Asp Thr Ile Gly Val Ala Val 
        35                  40                  45              


Asp Leu Ile Leu Leu Phe Arg Glu Leu Arg Val Glu Gln Glu Ser Leu 
    50                  55                  60                  


Leu Thr Ala Phe Arg Cys Gly Leu Gln Phe Leu Gly Asn Ile Ala Ser 
65                  70                  75                  80  


Arg Asn Glu Asp Ser Gln Ser Ile Val Trp Val His Ala Phe Pro Glu 
                85                  90                  95      


Leu Phe Leu Ser Cys Leu Asn His Pro Asp Lys Lys Ile Val Ala Tyr 
            100                 105                 110         


Ser Ser Met Ile Leu Phe Thr Ser Leu Asn His Glu Arg Met Lys Glu 
        115                 120                 125             


Leu Glu Glu Asn Leu Asn Ile Ala Ile Asp Val Ile Asp Ala Tyr Gln 
    130                 135                 140                 


Lys His Pro Glu Ser Glu Trp Pro Phe Leu Ile Ile Thr Asp Leu Phe 
145                 150                 155                 160 


Leu Lys Ser Pro Glu Leu Val Gln Ala Met Phe Pro Lys Leu Asn Asn 
                165                 170                 175     


Gln Glu Arg Val Thr Leu Leu Asp Leu Met Ile Ala Lys Ile Thr Ser 
            180                 185                 190         


Asp Glu Pro Leu Thr Lys Asp Asp Ile Pro Val Phe Leu Arg His Ala 
        195                 200                 205             


Glu Leu Ile Ala Ser Thr Phe Val Asp Gln Cys Lys Thr Val Leu Lys 
    210                 215                 220                 


Leu Ala Ser Glu Glu Pro Pro Asp Asp Glu Glu Ala Leu Ala Thr Ile 
225                 230                 235                 240 


Arg Leu Leu Asp Val Leu Cys Glu Met Thr Val Asn Thr Glu Leu Leu 
                245                 250                 255     


Gly Tyr Leu Gln Val Phe Pro Gly Leu Leu Glu Arg Val Ile Asp Leu 
            260                 265                 270         


Leu Arg Val Ile His Val Ala Gly Lys Glu Thr Thr Asn Ile Phe Ser 
        275                 280                 285             


Asn Cys Gly Cys Val Arg Ala Glu Gly Asp Ile Ser Asn Val Ala Asn 
    290                 295                 300                 


Gly Phe Lys Ser His Leu Ile Arg Leu Ile Gly Asn Leu Cys Tyr Lys 
305                 310                 315                 320 


Asn Lys Asp Asn Gln Asp Lys Val Asn Glu Leu Asp Gly Ile Pro Leu 
                325                 330                 335     


Ile Leu Asp Asn Cys Asn Ile Ser Asp Ser Asn Pro Phe Leu Thr Gln 
            340                 345                 350         


Trp Val Ile Tyr Ala Ile Arg Asn Leu Thr Glu Asp Asn Ser Gln Asn 
        355                 360                 365             


Gln Asp Leu Ile Ala Lys Met Glu Glu Gln Gly Leu Ala Asp Ala Ser 
    370                 375                 380                 


Leu Leu Lys Lys Val Gly Phe Glu Val Glu Lys Lys Gly Glu Lys Leu 
385                 390                 395                 400 


Ile Leu Lys Ser Thr Arg Asp Thr Pro Lys Pro 
                405                 410     


<210>  978
<211>  815
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN1__Homo_sapiens__NP_001121636

<400>  978

Met Lys Ser Asn Gln Glu Arg Ser Asn Glu Cys Leu Pro Pro Lys Lys 
1               5                   10                  15      


Arg Glu Ile Pro Ala Thr Ser Arg Ser Ser Glu Glu Lys Ala Pro Thr 
            20                  25                  30          


Leu Pro Ser Asp Asn His Arg Val Glu Gly Thr Ala Trp Leu Pro Gly 
        35                  40                  45              


Asn Pro Gly Gly Arg Gly His Gly Gly Gly Arg His Gly Pro Ala Gly 
    50                  55                  60                  


Thr Ser Val Glu Leu Gly Leu Gln Gln Gly Ile Gly Leu His Lys Ala 
65                  70                  75                  80  


Leu Ser Thr Gly Leu Asp Tyr Ser Pro Pro Ser Ala Pro Arg Ser Val 
                85                  90                  95      


Pro Val Ala Thr Thr Leu Pro Ala Ala Tyr Ala Thr Pro Gln Pro Gly 
            100                 105                 110         


Thr Pro Val Ser Pro Val Gln Tyr Ala His Leu Pro His Thr Phe Gln 
        115                 120                 125             


Phe Ile Gly Ser Ser Gln Tyr Ser Gly Thr Tyr Ala Ser Phe Ile Pro 
    130                 135                 140                 


Ser Gln Leu Ile Pro Pro Thr Ala Asn Pro Val Thr Ser Ala Val Ala 
145                 150                 155                 160 


Ser Ala Ala Gly Ala Thr Thr Pro Ser Gln Arg Ser Gln Leu Glu Ala 
                165                 170                 175     


Tyr Ser Thr Leu Leu Ala Asn Met Gly Ser Leu Ser Gln Thr Pro Gly 
            180                 185                 190         


His Lys Ala Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


His Gln His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln His Leu Ser Arg Ala Pro Gly Leu Ile Thr Pro Gly Ser Pro Pro 
225                 230                 235                 240 


Pro Ala Gln Gln Asn Gln Tyr Val His Ile Ser Ser Ser Pro Gln Asn 
                245                 250                 255     


Thr Gly Arg Thr Ala Ser Pro Pro Ala Ile Pro Val His Leu His Pro 
            260                 265                 270         


His Gln Thr Met Ile Pro His Thr Leu Thr Leu Gly Pro Pro Ser Gln 
        275                 280                 285             


Val Val Met Gln Tyr Ala Asp Ser Gly Ser His Phe Val Pro Arg Glu 
    290                 295                 300                 


Ala Thr Lys Lys Ala Glu Ser Ser Arg Leu Gln Gln Ala Ile Gln Ala 
305                 310                 315                 320 


Lys Glu Val Leu Asn Gly Glu Met Glu Lys Ser Arg Arg Tyr Gly Ala 
                325                 330                 335     


Pro Ser Ser Ala Asp Leu Gly Leu Gly Lys Ala Gly Gly Lys Ser Val 
            340                 345                 350         


Pro His Pro Tyr Glu Ser Arg His Val Val Val His Pro Ser Pro Ser 
        355                 360                 365             


Asp Tyr Ser Ser Arg Asp Pro Ser Gly Val Arg Ala Ser Val Met Val 
    370                 375                 380                 


Leu Pro Asn Ser Asn Thr Pro Ala Ala Asp Leu Glu Val Gln Gln Ala 
385                 390                 395                 400 


Thr His Arg Glu Ala Ser Pro Ser Thr Leu Asn Asp Lys Ser Gly Leu 
                405                 410                 415     


His Leu Gly Lys Pro Gly His Arg Ser Tyr Ala Leu Ser Pro His Thr 
            420                 425                 430         


Val Ile Gln Thr Thr His Ser Ala Ser Glu Pro Leu Pro Val Gly Leu 
        435                 440                 445             


Pro Ala Thr Ala Phe Tyr Ala Gly Thr Gln Pro Pro Val Ile Gly Tyr 
    450                 455                 460                 


Leu Ser Gly Gln Gln Gln Ala Ile Thr Tyr Ala Gly Ser Leu Pro Gln 
465                 470                 475                 480 


His Leu Val Ile Pro Gly Thr Gln Pro Leu Leu Ile Pro Val Gly Ser 
                485                 490                 495     


Thr Asp Met Glu Ala Ser Gly Ala Ala Pro Ala Ile Val Thr Ser Ser 
            500                 505                 510         


Pro Gln Phe Ala Ala Val Pro His Thr Phe Val Thr Thr Ala Leu Pro 
        515                 520                 525             


Lys Ser Glu Asn Phe Asn Pro Glu Ala Leu Val Thr Gln Ala Ala Tyr 
    530                 535                 540                 


Pro Ala Met Val Gln Ala Gln Ile His Leu Pro Val Val Gln Ser Val 
545                 550                 555                 560 


Ala Ser Pro Ala Ala Ala Pro Pro Thr Leu Pro Pro Tyr Phe Met Lys 
                565                 570                 575     


Gly Ser Ile Ile Gln Leu Ala Asn Gly Glu Leu Lys Lys Val Glu Asp 
            580                 585                 590         


Leu Lys Thr Glu Asp Phe Ile Gln Ser Ala Glu Ile Ser Asn Asp Leu 
        595                 600                 605             


Lys Ile Asp Ser Ser Thr Val Glu Arg Ile Glu Asp Ser His Ser Pro 
    610                 615                 620                 


Gly Val Ala Val Ile Gln Phe Ala Val Gly Glu His Arg Ala Gln Val 
625                 630                 635                 640 


Ser Val Glu Val Leu Val Glu Tyr Pro Phe Phe Val Phe Gly Gln Gly 
                645                 650                 655     


Trp Ser Ser Cys Cys Pro Glu Arg Thr Ser Gln Leu Phe Asp Leu Pro 
            660                 665                 670         


Cys Ser Lys Leu Ser Val Gly Asp Val Cys Ile Ser Leu Thr Leu Lys 
        675                 680                 685             


Asn Leu Lys Asn Gly Ser Val Lys Lys Gly Gln Pro Val Asp Pro Ala 
    690                 695                 700                 


Ser Val Leu Leu Lys His Ser Lys Ala Asp Gly Leu Ala Gly Ser Arg 
705                 710                 715                 720 


His Arg Tyr Ala Glu Gln Glu Asn Gly Ile Asn Gln Gly Ser Ala Gln 
                725                 730                 735     


Met Leu Ser Glu Asn Gly Glu Leu Lys Phe Pro Glu Lys Met Gly Leu 
            740                 745                 750         


Pro Ala Ala Pro Phe Leu Thr Lys Ile Glu Pro Ser Lys Pro Ala Ala 
        755                 760                 765             


Thr Arg Lys Arg Arg Trp Ser Ala Pro Glu Ser Arg Lys Leu Glu Lys 
    770                 775                 780                 


Ser Glu Asp Glu Pro Pro Leu Thr Leu Pro Lys Pro Ser Leu Ile Pro 
785                 790                 795                 800 


Gln Glu Val Lys Ile Cys Ile Glu Gly Arg Ser Asn Val Gly Lys 
                805                 810                 815 


<210>  979
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN1L__Homo_sapiens__NP_001131147

<400>  979

Met Lys Pro Val His Glu Arg Ser Gln Glu Cys Leu Pro Pro Lys Lys 
1               5                   10                  15      


Arg Asp Leu Pro Val Thr Ser Glu Asp Met Gly Arg Thr Thr Ser Cys 
            20                  25                  30          


Ser Thr Asn His Thr Pro Ser Ser Asp Ala Ser Glu Trp Ser Arg Gly 
        35                  40                  45              


Val Val Val Ala Gly Gln Ser Gln Ala Gly Ala Arg Val Ser Leu Gly 
    50                  55                  60                  


Gly Asp Gly Ala Glu Ala Ile Thr Gly Leu Thr Val Asp Gln Tyr Gly 
65                  70                  75                  80  


Met Leu Tyr Lys Val Ala Val Pro Pro Ala Thr Phe Ser Pro Thr Gly 
                85                  90                  95      


Leu Pro Ser Val Val Asn Met Ser Pro Leu Pro Pro Thr Phe Asn Val 
            100                 105                 110         


Ala Ser Ser Leu Ile Gln His Pro Gly Ile His Tyr Pro Pro Leu His 
        115                 120                 125             


Tyr Ala Gln Leu Pro Ser Thr Ser Leu Gln Phe Ile Gly Ser Pro Tyr 
    130                 135                 140                 


Ser Leu Pro Tyr Ala Val Pro Pro Asn Phe Leu Pro Ser Pro Leu Leu 
145                 150                 155                 160 


Ser Pro Ser Ala Asn Leu Ala Thr Ser His Leu Pro His Phe Val Pro 
                165                 170                 175     


Tyr Ala Ser Leu Leu Ala Glu Gly Ala Thr Pro Pro Pro Gln Ala Pro 
            180                 185                 190         


Ser Pro Ala His Ser Phe Asn Lys Ala Pro Ser Ala Thr Ser Pro Ser 
        195                 200                 205             


Gly Gln Leu Pro His His Ser Ser Thr Gln Pro Leu Asp Leu Ala Pro 
    210                 215                 220                 


Gly Arg Met Pro Ile Tyr Tyr Gln Met Ser Arg Leu Pro Ala Gly Tyr 
225                 230                 235                 240 


Thr Leu His Glu Thr Pro Pro Ala Gly Ala Ser Pro Val Leu Thr Pro 
                245                 250                 255     


Gln Glu Ser Gln Ser Ala Leu Glu Ala Ala Ala Ala Asn Gly Gly Gln 
            260                 265                 270         


Arg Pro Arg Glu Arg Asn Leu Val Arg Arg Glu Ser Glu Ala Leu Asp 
        275                 280                 285             


Ser Pro Asn Ser Lys Gly Glu Gly Gln Gly Leu Val Pro Val Val Glu 
    290                 295                 300                 


Cys Val Val Asp Gly Gln Leu Phe Ser Gly Ser Gln Thr Pro Arg Val 
305                 310                 315                 320 


Glu Val Ala Ala Pro Ala His Arg Gly Thr Pro Asp Thr Asp Leu Glu 
                325                 330                 335     


Val Gln Arg Val Val Gly Ala Leu Ala Ser Gln Asp Tyr Arg Val Val 
            340                 345                 350         


Ala Ala Gln Arg Lys Glu Glu Pro Ser Pro Leu Asn Leu Ser His His 
        355                 360                 365             


Thr Pro Asp His Gln Gly Glu Gly Arg Gly Ser Ala Arg Asn Pro Ala 
    370                 375                 380                 


Glu Leu Ala Glu Lys Ser Gln Ala Arg Gly Phe Tyr Pro Gln Ser His 
385                 390                 395                 400 


Gln Glu Pro Val Lys His Arg Pro Leu Pro Lys Ala Met Val Val Ala 
                405                 410                 415     


Asn Gly Asn Leu Val Pro Thr Gly Thr Asp Ser Gly Leu Leu Pro Val 
            420                 425                 430         


Gly Ser Glu Ile Leu Val Ala Ser Ser Leu Asp Val Gln Ala Arg Ala 
        435                 440                 445             


Thr Phe Pro Asp Lys Glu Pro Thr Pro Pro Pro Ile Thr Ser Ser His 
    450                 455                 460                 


Leu Pro Ser His Phe Met Lys Gly Ala Ile Ile Gln Leu Ala Thr Gly 
465                 470                 475                 480 


Glu Leu Lys Arg Val Glu Asp Leu Gln Thr Gln Asp Phe Val Arg Ser 
                485                 490                 495     


Ala Glu Val Ser Gly Gly Leu Lys Ile Asp Ser Ser Thr Val Val Asp 
            500                 505                 510         


Ile Gln Glu Ser Gln Trp Pro Gly Phe Val Met Leu His Phe Val Val 
        515                 520                 525             


Gly Glu Gln Gln Ser Lys Val Ser Ile Glu Val Pro Pro Glu His Pro 
    530                 535                 540                 


Phe Phe Val Tyr Gly Gln Gly Trp Ser Ser Cys Ser Pro Gly Arg Thr 
545                 550                 555                 560 


Thr Gln Leu Phe Ser Leu Pro Cys His Arg Leu Gln Val Gly Asp Val 
                565                 570                 575     


Cys Ile Ser Ile Ser Leu Gln Ser Leu Asn Ser Asn Ser Val Ser Gln 
            580                 585                 590         


Ala Ser Cys Ala Pro Pro Ser Gln Leu Gly Pro Pro Arg Glu Arg Pro 
        595                 600                 605             


Glu Arg Thr Val Leu Gly Ser Arg Glu Leu Cys Asp Ser Glu Gly Lys 
    610                 615                 620                 


Ser Gln Pro Ala Gly Glu Gly Ser Arg Val Val Glu Pro Ser Gln Pro 
625                 630                 635                 640 


Glu Ser Gly Ala Gln Ala Cys Trp Pro Ala Pro Ser Phe Gln Arg Tyr 
                645                 650                 655     


Ser Met Gln Gly Glu Glu Ala Arg Ala Ala Leu Leu Arg Pro Ser Phe 
            660                 665                 670         


Ile Pro Gln Glu Val Lys Leu Ser Ile Glu Gly Arg Ser Asn Ala Gly 
        675                 680                 685             


Lys 
    


<210>  980
<211>  1313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN2__Homo_sapiens__NP_002964

<400>  980

Met Arg Ser Ala Ala Ala Ala Pro Arg Ser Pro Ala Val Ala Thr Glu 
1               5                   10                  15      


Ser Arg Arg Phe Ala Ala Ala Arg Trp Pro Gly Trp Arg Ser Leu Gln 
            20                  25                  30          


Arg Pro Ala Arg Arg Ser Gly Arg Gly Gly Gly Gly Ala Ala Pro Gly 
        35                  40                  45              


Pro Tyr Pro Ser Ala Ala Pro Pro Pro Pro Gly Pro Gly Pro Pro Pro 
    50                  55                  60                  


Ser Arg Gln Ser Ser Pro Pro Ser Ala Ser Asp Cys Phe Gly Ser Asn 
65                  70                  75                  80  


Gly Asn Gly Gly Gly Ala Phe Arg Pro Gly Ser Arg Arg Leu Leu Gly 
                85                  90                  95      


Leu Gly Gly Pro Pro Arg Pro Phe Val Val Leu Leu Leu Pro Leu Ala 
            100                 105                 110         


Ser Pro Gly Ala Pro Pro Ala Ala Pro Thr Arg Ala Ser Pro Leu Gly 
        115                 120                 125             


Ala Arg Ala Ser Pro Pro Arg Ser Gly Val Ser Leu Ala Arg Pro Ala 
    130                 135                 140                 


Pro Gly Cys Pro Arg Pro Ala Cys Glu Pro Val Tyr Gly Pro Leu Thr 
145                 150                 155                 160 


Met Ser Leu Lys Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Ala 
            180                 185                 190         


Ala Ala Asn Val Arg Lys Pro Gly Gly Ser Gly Leu Leu Ala Ser Pro 
        195                 200                 205             


Ala Ala Ala Pro Ser Pro Ser Ser Ser Ser Val Ser Ser Ser Ser Ala 
    210                 215                 220                 


Thr Ala Pro Ser Ser Val Val Ala Ala Thr Ser Gly Gly Gly Arg Pro 
225                 230                 235                 240 


Gly Leu Gly Arg Gly Arg Asn Ser Asn Lys Gly Leu Pro Gln Ser Thr 
                245                 250                 255     


Ile Ser Phe Asp Gly Ile Tyr Ala Asn Met Arg Met Val His Ile Leu 
            260                 265                 270         


Thr Ser Val Val Gly Ser Lys Cys Glu Val Gln Val Lys Asn Gly Gly 
        275                 280                 285             


Ile Tyr Glu Gly Val Phe Lys Thr Tyr Ser Pro Lys Cys Asp Leu Val 
    290                 295                 300                 


Leu Asp Ala Ala His Glu Lys Ser Thr Glu Ser Ser Ser Gly Pro Lys 
305                 310                 315                 320 


Arg Glu Glu Ile Met Glu Ser Ile Leu Phe Lys Cys Ser Asp Phe Val 
                325                 330                 335     


Val Val Gln Phe Lys Asp Met Asp Ser Ser Tyr Ala Lys Arg Asp Ala 
            340                 345                 350         


Phe Thr Asp Ser Ala Ile Ser Ala Lys Val Asn Gly Glu His Lys Glu 
        355                 360                 365             


Lys Asp Leu Glu Pro Trp Asp Ala Gly Glu Leu Thr Ala Asn Glu Glu 
    370                 375                 380                 


Leu Glu Ala Leu Glu Asn Asp Val Ser Asn Gly Trp Asp Pro Asn Asp 
385                 390                 395                 400 


Met Phe Arg Tyr Asn Glu Glu Asn Tyr Gly Val Val Ser Thr Tyr Asp 
                405                 410                 415     


Ser Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Arg Asp Asn Ser Glu 
            420                 425                 430         


Glu Phe Leu Lys Arg Glu Ala Arg Ala Asn Gln Leu Ala Glu Glu Ile 
        435                 440                 445             


Glu Ser Ser Ala Gln Tyr Lys Ala Arg Val Ala Leu Glu Asn Asp Asp 
    450                 455                 460                 


Arg Ser Glu Glu Glu Lys Tyr Thr Ala Val Gln Arg Asn Ser Ser Glu 
465                 470                 475                 480 


Arg Glu Gly His Ser Ile Asn Thr Arg Glu Asn Lys Tyr Ile Pro Pro 
                485                 490                 495     


Gly Gln Arg Asn Arg Glu Val Ile Ser Trp Gly Ser Gly Arg Gln Asn 
            500                 505                 510         


Ser Pro Arg Met Gly Gln Pro Gly Ser Gly Ser Met Pro Ser Arg Ser 
        515                 520                 525             


Thr Ser His Thr Ser Asp Phe Asn Pro Asn Ser Gly Ser Asp Gln Arg 
    530                 535                 540                 


Val Val Asn Gly Gly Val Pro Trp Pro Ser Pro Cys Pro Ser Pro Ser 
545                 550                 555                 560 


Ser Arg Pro Pro Ser Arg Tyr Gln Ser Gly Pro Asn Ser Leu Pro Pro 
                565                 570                 575     


Arg Ala Ala Thr Pro Thr Arg Pro Pro Ser Arg Pro Pro Ser Arg Pro 
            580                 585                 590         


Ser Arg Pro Pro Ser His Pro Ser Ala His Gly Ser Pro Ala Pro Val 
        595                 600                 605             


Ser Thr Met Pro Lys Arg Met Ser Ser Glu Gly Pro Pro Arg Met Ser 
    610                 615                 620                 


Pro Lys Ala Gln Arg His Pro Arg Asn His Arg Val Ser Ala Gly Arg 
625                 630                 635                 640 


Gly Ser Ile Ser Ser Gly Leu Glu Phe Val Ser His Asn Pro Pro Ser 
                645                 650                 655     


Glu Ala Ala Thr Pro Pro Val Ala Arg Thr Ser Pro Ser Gly Gly Thr 
            660                 665                 670         


Trp Ser Ser Val Val Ser Gly Val Pro Arg Leu Ser Pro Lys Thr His 
        675                 680                 685             


Arg Pro Arg Ser Pro Arg Gln Asn Ser Ile Gly Asn Thr Pro Ser Gly 
    690                 695                 700                 


Pro Val Leu Ala Ser Pro Gln Ala Gly Ile Ile Pro Thr Glu Ala Val 
705                 710                 715                 720 


Ala Met Pro Ile Pro Ala Ala Ser Pro Thr Pro Ala Ser Pro Ala Ser 
                725                 730                 735     


Asn Arg Ala Val Thr Pro Ser Ser Glu Ala Lys Asp Ser Arg Leu Gln 
            740                 745                 750         


Asp Gln Arg Gln Asn Ser Pro Ala Gly Asn Lys Glu Asn Ile Lys Pro 
        755                 760                 765             


Asn Glu Thr Ser Pro Ser Phe Ser Lys Ala Glu Asn Lys Gly Ile Ser 
    770                 775                 780                 


Pro Val Val Ser Glu His Arg Lys Gln Ile Asp Asp Leu Lys Lys Phe 
785                 790                 795                 800 


Lys Asn Asp Phe Arg Leu Gln Pro Ser Ser Thr Ser Glu Ser Met Asp 
                805                 810                 815     


Gln Leu Leu Asn Lys Asn Arg Glu Gly Glu Lys Ser Arg Asp Leu Ile 
            820                 825                 830         


Lys Asp Lys Ile Glu Pro Ser Ala Lys Asp Ser Phe Ile Glu Asn Ser 
        835                 840                 845             


Ser Ser Asn Cys Thr Ser Gly Ser Ser Lys Pro Asn Ser Pro Ser Ile 
    850                 855                 860                 


Ser Pro Ser Ile Leu Ser Asn Thr Glu His Lys Arg Gly Pro Glu Val 
865                 870                 875                 880 


Thr Ser Gln Gly Val Gln Thr Ser Ser Pro Ala Cys Lys Gln Glu Lys 
                885                 890                 895     


Asp Asp Lys Glu Glu Lys Lys Asp Ala Ala Glu Gln Val Arg Lys Ser 
            900                 905                 910         


Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Arg Ser Phe Ser Gln 
        915                 920                 925             


Pro Lys Pro Ser Thr Thr Pro Thr Ser Pro Arg Pro Gln Ala Gln Pro 
    930                 935                 940                 


Ser Pro Ser Met Val Gly His Gln Gln Pro Thr Pro Val Tyr Thr Gln 
945                 950                 955                 960 


Pro Val Cys Phe Ala Pro Asn Met Met Tyr Pro Val Pro Val Ser Pro 
                965                 970                 975     


Gly Val Gln Pro Leu Tyr Pro Ile Pro Met Thr Pro Met Pro Val Asn 
            980                 985                 990         


Gln Ala Lys Thr Tyr Arg Ala Val  Pro Asn Met Pro Gln  Gln Arg Gln 
        995                 1000                 1005             


Asp Gln  His His Gln Ser Ala  Met Met His Pro Ala  Ser Ala Ala 
    1010                 1015                 1020             


Gly Pro  Pro Ile Ala Ala Thr  Pro Pro Ala Tyr Ser  Thr Gln Tyr 
    1025                 1030                 1035             


Val Ala  Tyr Ser Pro Gln Gln  Phe Pro Asn Gln Pro  Leu Val Gln 
    1040                 1045                 1050             


His Val  Pro His Tyr Gln Ser  Gln His Pro His Val  Tyr Ser Pro 
    1055                 1060                 1065             


Val Ile  Gln Gly Asn Ala Arg  Met Met Ala Pro Pro  Thr His Ala 
    1070                 1075                 1080             


Gln Pro  Gly Leu Val Ser Ser  Ser Ala Thr Gln Tyr  Gly Ala His 
    1085                 1090                 1095             


Glu Gln  Thr His Ala Met Tyr  Ala Cys Pro Lys Leu  Pro Tyr Asn 
    1100                 1105                 1110             


Lys Glu  Thr Ser Pro Ser Phe  Tyr Phe Ala Ile Ser  Thr Gly Ser 
    1115                 1120                 1125             


Leu Ala  Gln Gln Tyr Ala His  Pro Asn Ala Thr Leu  His Pro His 
    1130                 1135                 1140             


Thr Pro  His Pro Gln Pro Ser  Ala Thr Pro Thr Gly  Gln Gln Gln 
    1145                 1150                 1155             


Ser Gln  His Gly Gly Ser His  Pro Ala Pro Ser Pro  Val Gln His 
    1160                 1165                 1170             


His Gln  His Gln Ala Ala Gln  Ala Leu His Leu Ala  Ser Pro Gln 
    1175                 1180                 1185             


Gln Gln  Ser Ala Ile Tyr His  Ala Gly Leu Ala Pro  Thr Pro Pro 
    1190                 1195                 1200             


Ser Met  Thr Pro Ala Ser Asn  Thr Gln Ser Pro Gln  Asn Ser Phe 
    1205                 1210                 1215             


Pro Ala  Ala Gln Gln Thr Val  Phe Thr Ile His Pro  Ser His Val 
    1220                 1225                 1230             


Gln Pro  Ala Tyr Thr Asn Pro  Pro His Met Ala His  Val Pro Gln 
    1235                 1240                 1245             


Ala His  Val Gln Ser Gly Met  Val Pro Ser His Pro  Thr Ala His 
    1250                 1255                 1260             


Ala Pro  Met Met Leu Met Thr  Thr Gln Pro Pro Gly  Gly Pro Gln 
    1265                 1270                 1275             


Ala Ala  Leu Ala Gln Ser Ala  Leu Gln Pro Ile Pro  Val Ser Thr 
    1280                 1285                 1290             


Thr Ala  His Phe Pro Tyr Met  Thr His Pro Ser Val  Gln Ala His 
    1295                 1300                 1305             


His Gln  Gln Gln Leu 
    1310             


<210>  981
<211>  1075
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN2L__Homo_sapiens__NP_009176

<400>  981

Met Leu Lys Pro Gln Pro Leu Gln Gln Pro Ser Gln Pro Gln Gln Pro 
1               5                   10                  15      


Pro Pro Thr Gln Gln Ala Val Ala Arg Arg Pro Pro Gly Gly Thr Ser 
            20                  25                  30          


Pro Pro Asn Gly Gly Leu Pro Gly Pro Leu Ala Thr Ser Ala Ala Pro 
        35                  40                  45              


Pro Gly Pro Pro Ala Ala Ala Ser Pro Cys Leu Gly Pro Val Ala Ala 
    50                  55                  60                  


Ala Gly Ser Gly Leu Arg Arg Gly Ala Glu Gly Ile Leu Ala Pro Gln 
65                  70                  75                  80  


Pro Pro Pro Pro Gln Gln His Gln Glu Arg Pro Gly Ala Ala Ala Ile 
                85                  90                  95      


Gly Ser Ala Arg Gly Gln Ser Thr Gly Lys Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Val Phe Glu Gly Val Tyr Asn Asn Ser Arg Met Leu His Phe Leu Thr 
        115                 120                 125             


Ala Val Val Gly Ser Thr Cys Asp Val Lys Val Lys Asn Gly Thr Thr 
    130                 135                 140                 


Tyr Glu Gly Ile Phe Lys Thr Leu Ser Ser Lys Phe Glu Leu Ala Val 
145                 150                 155                 160 


Asp Ala Val His Arg Lys Ala Ser Glu Pro Ala Gly Gly Pro Arg Arg 
                165                 170                 175     


Glu Asp Ile Val Asp Thr Met Val Phe Lys Pro Ser Asp Val Met Leu 
            180                 185                 190         


Val His Phe Arg Asn Val Asp Phe Asn Tyr Ala Thr Lys Asp Lys Phe 
        195                 200                 205             


Thr Asp Ser Ala Ile Ala Met Asn Ser Lys Val Asn Gly Glu His Lys 
    210                 215                 220                 


Glu Lys Val Leu Gln Arg Trp Glu Gly Gly Asp Ser Asn Ser Asp Asp 
225                 230                 235                 240 


Tyr Asp Leu Glu Ser Asp Met Ser Asn Gly Trp Asp Pro Asn Glu Met 
                245                 250                 255     


Phe Lys Phe Asn Glu Glu Asn Tyr Gly Val Lys Thr Thr Tyr Asp Ser 
            260                 265                 270         


Ser Leu Ser Ser Tyr Thr Val Pro Leu Glu Lys Asp Asn Ser Glu Glu 
        275                 280                 285             


Phe Arg Gln Arg Glu Leu Arg Ala Ala Gln Leu Ala Arg Glu Ile Glu 
    290                 295                 300                 


Ser Ser Pro Gln Tyr Arg Leu Arg Ile Ala Met Glu Asn Asp Asp Gly 
305                 310                 315                 320 


Arg Thr Glu Glu Glu Lys His Ser Ala Val Gln Arg Gln Gly Ser Gly 
                325                 330                 335     


Arg Glu Ser Pro Ser Leu Ala Ser Arg Glu Gly Lys Tyr Ile Pro Leu 
            340                 345                 350         


Pro Gln Arg Val Arg Glu Gly Pro Arg Gly Gly Val Arg Cys Ser Ser 
        355                 360                 365             


Ser Arg Gly Gly Arg Pro Gly Leu Ser Ser Leu Pro Pro Arg Gly Pro 
    370                 375                 380                 


His His Leu Asp Asn Ser Ser Pro Gly Pro Gly Ser Glu Ala Arg Gly 
385                 390                 395                 400 


Ile Asn Gly Gly Pro Ser Arg Met Ser Pro Lys Ala Gln Arg Pro Leu 
                405                 410                 415     


Arg Gly Ala Lys Thr Leu Ser Ser Pro Ser Asn Arg Pro Ser Gly Glu 
            420                 425                 430         


Thr Ser Val Pro Pro Pro Pro Ala Val Gly Arg Met Tyr Pro Pro Arg 
        435                 440                 445             


Ser Pro Lys Ser Ala Ala Pro Ala Pro Ile Ser Ala Ser Cys Pro Glu 
    450                 455                 460                 


Pro Pro Ile Gly Ser Ala Val Pro Thr Ser Ser Ala Ser Ile Pro Val 
465                 470                 475                 480 


Thr Ser Ser Val Ser Asp Pro Gly Val Gly Ser Ile Ser Pro Ala Ser 
                485                 490                 495     


Pro Lys Ile Ser Leu Ala Pro Thr Asp Val Lys Glu Leu Ser Thr Lys 
            500                 505                 510         


Glu Pro Gly Arg Thr Leu Glu Pro Gln Glu Leu Ala Arg Ile Ala Gly 
        515                 520                 525             


Lys Val Pro Gly Leu Gln Asn Glu Gln Lys Arg Phe Gln Leu Glu Glu 
    530                 535                 540                 


Leu Arg Lys Phe Gly Ala Gln Phe Lys Leu Gln Pro Ser Ser Ser Pro 
545                 550                 555                 560 


Glu Asn Ser Leu Asp Pro Phe Pro Pro Arg Ile Leu Lys Glu Glu Pro 
                565                 570                 575     


Lys Gly Lys Glu Lys Glu Val Asp Gly Leu Leu Thr Ser Glu Pro Met 
            580                 585                 590         


Gly Ser Pro Val Ser Ser Lys Thr Glu Ser Val Ser Asp Lys Glu Asp 
        595                 600                 605             


Lys Pro Pro Leu Ala Pro Ser Gly Gly Thr Glu Gly Pro Glu Gln Pro 
    610                 615                 620                 


Pro Pro Pro Cys Pro Ser Gln Thr Gly Ser Pro Pro Val Gly Leu Ile 
625                 630                 635                 640 


Lys Gly Glu Asp Lys Asp Glu Gly Pro Val Ala Glu Gln Val Lys Lys 
                645                 650                 655     


Ser Thr Leu Asn Pro Asn Ala Lys Glu Phe Asn Pro Thr Lys Pro Leu 
            660                 665                 670         


Leu Ser Val Asn Lys Ser Thr Ser Thr Pro Thr Ser Pro Gly Pro Arg 
        675                 680                 685             


Thr His Ser Thr Pro Ser Ile Pro Val Leu Thr Ala Gly Gln Ser Gly 
    690                 695                 700                 


Leu Tyr Ser Pro Gln Tyr Ile Ser Tyr Ile Pro Gln Ile His Met Gly 
705                 710                 715                 720 


Pro Ala Val Gln Ala Pro Gln Met Tyr Pro Tyr Pro Val Ser Asn Ser 
                725                 730                 735     


Val Pro Gly Gln Gln Gly Lys Tyr Arg Gly Ala Lys Gly Ser Leu Pro 
            740                 745                 750         


Pro Gln Arg Ser Asp Gln His Gln Pro Ala Ser Ala Pro Pro Met Met 
        755                 760                 765             


Gln Ala Ala Ala Ala Ala Gly Pro Pro Leu Val Ala Ala Thr Pro Tyr 
    770                 775                 780                 


Ser Ser Tyr Ile Pro Tyr Asn Pro Gln Gln Phe Pro Gly Gln Pro Ala 
785                 790                 795                 800 


Met Met Gln Pro Met Ala His Tyr Pro Ser Gln Pro Val Phe Ala Pro 
                805                 810                 815     


Met Leu Gln Ser Asn Pro Arg Met Leu Thr Ser Gly Ser His Pro Gln 
            820                 825                 830         


Ala Ile Val Ser Ser Ser Thr Pro Gln Tyr Pro Ser Ala Glu Gln Pro 
        835                 840                 845             


Thr Pro Gln Ala Leu Tyr Ala Thr Val His Gln Ser Tyr Pro His His 
    850                 855                 860                 


Ala Thr Gln Leu His Ala His Gln Pro Gln Pro Ala Thr Thr Pro Thr 
865                 870                 875                 880 


Gly Ser Gln Pro Gln Ser Gln His Ala Ala Pro Ser Pro Val Gln His 
                885                 890                 895     


Gln Ala Gly Gln Ala Pro His Leu Gly Ser Gly Gln Pro Gln Gln Asn 
            900                 905                 910         


Leu Tyr His Pro Gly Ala Leu Thr Gly Thr Pro Pro Ser Leu Pro Pro 
        915                 920                 925             


Gly Pro Ser Ala Gln Ser Pro Gln Ser Ser Phe Pro Gln Pro Ala Ala 
    930                 935                 940                 


Val Tyr Ala Ile His His Gln Gln Leu Pro His Gly Phe Thr Asn Met 
945                 950                 955                 960 


Ala His Val Thr Gln Ala His Val Gln Thr Gly Ile Thr Ala Ala Pro 
                965                 970                 975     


Pro Pro His Pro Gly Ala Pro His Pro Pro Gln Val Met Leu Leu His 
            980                 985                 990         


Pro Pro Gln Ser His Gly Gly Pro  Pro Gln Gly Ala Val  Pro Gln Ser 
        995                 1000                 1005             


Gly Val  Pro Ala Leu Ser Ala  Ser Thr Pro Ser Pro  Tyr Pro Tyr 
    1010                 1015                 1020             


Ile Gly  His Pro Gln Gly Glu  Gln Pro Gly Gln Ala  Pro Gly Phe 
    1025                 1030                 1035             


Pro Gly  Gly Ala Asp Asp Arg  Ile Arg Glu Phe Ser  Leu Ala Gly 
    1040                 1045                 1050             


Gly Ile  Trp His Gly Arg Ala  Glu Gly Leu Gln Val  Gly Gln Asp 
    1055                 1060                 1065             


Ala Arg  Val Leu Gly Gly Glu  
    1070                 1075 


<210>  982
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN3__Homo_sapiens__NP_001121168

<400>  982

Met Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Val 
    50                  55                  60                  


Ile Ser Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn 
65                  70                  75                  80  


Ser Pro Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser 
                85                  90                  95      


Phe Ile Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly 
            100                 105                 110         


Lys Gln Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile 
        115                 120                 125             


Ser Asp Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly 
    130                 135                 140                 


Tyr Ser Ile Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp 
145                 150                 155                 160 


Gln Leu Leu Gln Met Ile Arg Val Gln Gln Met His Arg Pro Lys Leu 
                165                 170                 175     


Ile Gly Glu Glu Leu Ala Gln Leu Lys Glu Gln Arg Val His Lys Thr 
            180                 185                 190         


Asp Leu Glu Arg Val Leu Glu Ala Asn Asp Gly Ser Gly Met Leu Asp 
        195                 200                 205             


Glu Asp Glu Glu Asp Leu Gln Arg Ala Leu Ala Leu Ser Arg Gln Glu 
    210                 215                 220                 


Ile Asp Met Glu Asp Glu Glu Ala Asp Leu Arg Arg Ala Ile Gln Leu 
225                 230                 235                 240 


Ser Met Gln Gly Ser Ser Arg Asn Ile Ser Gln Asp Met Thr Gln Thr 
                245                 250                 255     


Ser Gly Thr Asn Leu Thr Ser Glu Glu Leu Arg Lys Arg Arg Glu Ala 
            260                 265                 270         


Tyr Phe Glu Lys Gln Gln Gln Lys Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Gly Asp Leu Ser Gly Gln Ser Ser His Pro Cys Glu Arg Pro 
    290                 295                 300                 


Ala Thr Ser Ser Gly Ala Leu Gly Ser Asp Leu Gly Asp Ala Met Ser 
305                 310                 315                 320 


Glu Glu Asp Met Leu Gln Ala Ala Val Thr Met Ser Leu Glu Thr Val 
                325                 330                 335     


Arg Asn Asp Leu Lys Thr Glu Gly Lys Lys 
            340                 345     


<210>  983
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN7__Homo_sapiens__NP_000324

<400>  983

Met Ser Glu Arg Ala Ala Asp Asp Val Arg Gly Glu Pro Arg Arg Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Arg Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Gln Pro Gln Arg Gln 
        35                  40                  45              


Gln His Pro Pro Pro Pro Pro Arg Arg Thr Arg Pro Glu Asp Gly Gly 
    50                  55                  60                  


Pro Gly Ala Ala Ser Thr Ser Ala Ala Ala Met Ala Thr Val Gly Glu 
65                  70                  75                  80  


Arg Arg Pro Leu Pro Ser Pro Glu Val Met Leu Gly Gln Ser Trp Asn 
                85                  90                  95      


Leu Trp Val Glu Ala Ser Lys Leu Pro Gly Lys Asp Gly Thr Glu Leu 
            100                 105                 110         


Asp Glu Ser Phe Lys Glu Phe Gly Lys Asn Arg Glu Val Met Gly Leu 
        115                 120                 125             


Cys Arg Glu Asp Met Pro Ile Phe Gly Phe Cys Pro Ala His Asp Asp 
    130                 135                 140                 


Phe Tyr Leu Val Val Cys Asn Asp Cys Asn Gln Val Val Lys Pro Gln 
145                 150                 155                 160 


Ala Phe Gln Ser His Tyr Glu Arg Arg His Ser Ser Ser Ser Lys Pro 
                165                 170                 175     


Pro Leu Ala Val Pro Pro Thr Ser Val Phe Ser Phe Phe Pro Ser Leu 
            180                 185                 190         


Ser Lys Ser Lys Gly Gly Ser Ala Ser Gly Ser Asn Arg Ser Ser Ser 
        195                 200                 205             


Gly Gly Val Leu Ser Ala Ser Ser Ser Ser Ser Lys Leu Leu Lys Ser 
    210                 215                 220                 


Pro Lys Glu Lys Leu Gln Leu Arg Gly Asn Thr Arg Pro Met His Pro 
225                 230                 235                 240 


Ile Gln Gln Ser Arg Val Pro His Gly Arg Ile Met Thr Pro Ser Val 
                245                 250                 255     


Lys Val Glu Lys Ile His Pro Lys Met Asp Gly Thr Leu Leu Lys Ser 
            260                 265                 270         


Ala Val Gly Pro Thr Cys Pro Ala Thr Val Ser Ser Leu Val Lys Pro 
        275                 280                 285             


Gly Leu Asn Cys Pro Ser Ile Pro Lys Pro Thr Leu Pro Ser Pro Gly 
    290                 295                 300                 


Gln Ile Leu Asn Gly Lys Gly Leu Pro Ala Pro Pro Thr Leu Glu Lys 
305                 310                 315                 320 


Lys Pro Glu Asp Asn Ser Asn Asn Arg Lys Phe Leu Asn Lys Arg Leu 
                325                 330                 335     


Ser Glu Arg Glu Phe Asp Pro Asp Ile His Cys Gly Val Ile Asp Leu 
            340                 345                 350         


Asp Thr Lys Lys Pro Cys Thr Arg Ser Leu Thr Cys Lys Thr His Ser 
        355                 360                 365             


Leu Thr Gln Arg Arg Ala Val Gln Gly Arg Arg Lys Arg Phe Asp Val 
    370                 375                 380                 


Leu Leu Ala Glu His Lys Asn Lys Thr Arg Glu Lys Glu Leu Ile Arg 
385                 390                 395                 400 


His Pro Asp Ser Gln Gln Pro Pro Gln Pro Leu Arg Asp Pro His Pro 
                405                 410                 415     


Ala Pro Pro Arg Thr Ser Gln Glu Pro His Gln Asn Pro His Gly Val 
            420                 425                 430         


Ile Pro Ser Glu Ser Lys Pro Phe Val Ala Ser Lys Pro Lys Pro His 
        435                 440                 445             


Thr Pro Ser Leu Pro Arg Pro Pro Gly Cys Pro Ala Gln Gln Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ile Asp Pro Pro Pro Val His Glu Ser Pro His Pro Pro 
465                 470                 475                 480 


Leu Pro Ala Thr Glu Pro Ala Ser Arg Leu Ser Ser Glu Glu Gly Glu 
                485                 490                 495     


Gly Asp Asp Lys Glu Glu Ser Val Glu Lys Leu Asp Cys His Tyr Ser 
            500                 505                 510         


Gly His His Pro Gln Pro Ala Ser Phe Cys Thr Phe Gly Ser Arg Gln 
        515                 520                 525             


Ile Gly Arg Gly Tyr Tyr Val Phe Asp Ser Arg Trp Asn Arg Leu Arg 
    530                 535                 540                 


Cys Ala Leu Asn Leu Met Val Glu Lys His Leu Asn Ala Gln Leu Trp 
545                 550                 555                 560 


Lys Lys Ile Pro Pro Val Pro Ser Thr Thr Ser Pro Ile Ser Thr Arg 
                565                 570                 575     


Ile Pro His Arg Thr Asn Ser Val Pro Thr Ser Gln Cys Gly Val Ser 
            580                 585                 590         


Tyr Leu Ala Ala Ala Thr Val Ser Thr Ser Pro Val Leu Leu Ser Ser 
        595                 600                 605             


Thr Cys Ile Ser Pro Asn Ser Lys Ser Val Pro Ala His Gly Thr Thr 
    610                 615                 620                 


Leu Asn Ala Gln Pro Ala Ala Ser Gly Ala Met Asp Pro Val Cys Ser 
625                 630                 635                 640 


Met Gln Ser Arg Gln Val Ser Ser Ser Ser Ser Ser Pro Ser Thr Pro 
                645                 650                 655     


Ser Gly Leu Ser Ser Val Pro Ser Ser Pro Met Ser Arg Lys Pro Gln 
            660                 665                 670         


Lys Leu Lys Ser Ser Lys Ser Leu Arg Pro Lys Glu Ser Ser Gly Asn 
        675                 680                 685             


Ser Thr Asn Cys Gln Asn Ala Ser Ser Ser Thr Ser Gly Gly Ser Gly 
    690                 695                 700                 


Lys Lys Arg Lys Asn Ser Ser Pro Leu Leu Val His Ser Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Ser Ser Ser Ser Ser His Ser Met Glu Ser Phe Arg Lys 
                725                 730                 735     


Asn Cys Val Ala His Ser Gly Pro Pro Tyr Pro Ser Thr Val Thr Ser 
            740                 745                 750         


Ser His Ser Ile Gly Leu Asn Cys Val Thr Asn Lys Ala Asn Ala Val 
        755                 760                 765             


Asn Val Arg His Asp Gln Ser Gly Arg Gly Pro Pro Thr Gly Ser Pro 
    770                 775                 780                 


Ala Glu Ser Ile Lys Arg Met Ser Val Met Val Asn Ser Ser Asp Ser 
785                 790                 795                 800 


Thr Leu Ser Leu Gly Pro Phe Ile His Gln Ser Asn Glu Leu Pro Val 
                805                 810                 815     


Asn Ser His Gly Ser Phe Ser His Ser His Thr Pro Leu Asp Lys Leu 
            820                 825                 830         


Ile Gly Lys Lys Arg Lys Cys Ser Pro Ser Ser Ser Ser Ile Asn Asn 
        835                 840                 845             


Ser Ser Ser Lys Pro Thr Lys Val Ala Lys Val Pro Ala Val Asn Asn 
    850                 855                 860                 


Val His Met Lys His Thr Gly Thr Ile Pro Gly Ala Gln Gly Leu Met 
865                 870                 875                 880 


Asn Ser Ser Leu Leu His Gln Pro Lys Ala Arg Pro 
                885                 890         


<210>  984
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATXN7L3B__Homo_sapiens__NP_001129734

<400>  984

Met Glu Glu Ile Ser Leu Ala Asn Leu Asp Thr Asn Lys Leu Glu Ala 
1               5                   10                  15      


Ile Ala Gln Glu Ile Tyr Val Asp Leu Ile Glu Asp Ser Cys Leu Gly 
            20                  25                  30          


Phe Cys Phe Glu Val His Arg Ala Val Lys Cys Gly Tyr Phe Tyr Leu 
        35                  40                  45              


Glu Phe Ala Glu Thr Gly Ser Val Lys Asp Phe Gly Ile Gln Pro Val 
    50                  55                  60                  


Glu Asp Lys Gly Ala Cys Arg Leu Pro Leu Cys Ser Leu Pro Gly Glu 
65                  70                  75                  80  


Pro Gly Asn Gly Pro Asp Gln Gln Leu Gln Arg Ser Pro Pro Glu Phe 
                85                  90                  95      


Gln 
    


<210>  985
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AUH__Homo_sapiens__NP_001689

<400>  985

Met Ala Ala Ala Val Ala Ala Ala Pro Gly Ala Leu Gly Ser Leu His 
1               5                   10                  15      


Ala Gly Gly Ala Arg Leu Val Ala Ala Cys Ser Ala Trp Leu Cys Pro 
            20                  25                  30          


Gly Leu Arg Leu Pro Gly Ser Leu Ala Gly Arg Arg Ala Gly Pro Ala 
        35                  40                  45              


Ile Trp Ala Gln Gly Trp Val Pro Ala Ala Gly Gly Pro Ala Pro Lys 
    50                  55                  60                  


Arg Gly Tyr Ser Ser Glu Met Lys Thr Glu Asp Glu Leu Arg Val Arg 
65                  70                  75                  80  


His Leu Glu Glu Glu Asn Arg Gly Ile Val Val Leu Gly Ile Asn Arg 
                85                  90                  95      


Ala Tyr Gly Lys Asn Ser Leu Ser Lys Asn Leu Ile Lys Met Leu Ser 
            100                 105                 110         


Lys Ala Val Asp Ala Leu Lys Ser Asp Lys Lys Val Arg Thr Ile Ile 
        115                 120                 125             


Ile Arg Ser Glu Val Pro Gly Ile Phe Cys Ala Gly Ala Asp Leu Lys 
    130                 135                 140                 


Glu Arg Ala Lys Met Ser Ser Ser Glu Val Gly Pro Phe Val Ser Lys 
145                 150                 155                 160 


Ile Arg Ala Val Ile Asn Asp Ile Ala Asn Leu Pro Val Pro Thr Ile 
                165                 170                 175     


Ala Ala Ile Asp Gly Leu Ala Leu Gly Gly Gly Leu Glu Leu Ala Leu 
            180                 185                 190         


Ala Cys Asp Ile Arg Val Ala Ala Ser Ser Ala Lys Met Gly Leu Val 
        195                 200                 205             


Glu Thr Lys Leu Ala Ile Ile Pro Gly Gly Gly Gly Thr Gln Arg Leu 
    210                 215                 220                 


Pro Arg Ala Ile Gly Met Ser Leu Ala Lys Glu Leu Ile Phe Ser Ala 
225                 230                 235                 240 


Arg Val Leu Asp Gly Lys Glu Ala Lys Ala Val Gly Leu Ile Ser His 
                245                 250                 255     


Val Leu Glu Gln Asn Gln Glu Gly Asp Ala Ala Tyr Arg Lys Ala Leu 
            260                 265                 270         


Asp Leu Ala Arg Glu Phe Leu Pro Gln Gly Pro Val Ala Met Arg Val 
        275                 280                 285             


Ala Lys Leu Ala Ile Asn Gln Gly Met Glu Val Asp Leu Val Thr Gly 
    290                 295                 300                 


Leu Ala Ile Glu Glu Ala Cys Tyr Ala Gln Thr Ile Pro Thr Lys Asp 
305                 310                 315                 320 


Arg Leu Glu Gly Leu Leu Ala Phe Lys Glu Lys Arg Pro Pro Arg Tyr 
                325                 330                 335     


Lys Gly Glu 
            


<210>  986
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AURKA__Homo_sapiens__XP_006723935

<400>  986

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  987
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AURKB__Homo_sapiens__NP_001271455

<400>  987

Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg Arg His Phe Thr Ile Asp Asp Phe Glu Ile 
65                  70                  75                  80  


Gly Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg 
                85                  90                  95      


Glu Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser 
            100                 105                 110         


Gln Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu 
        115                 120                 125             


Ile Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr 
    130                 135                 140                 


Phe Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg 
145                 150                 155                 160 


Gly Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln 
                165                 170                 175     


Arg Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys 
            180                 185                 190         


His Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu 
        195                 200                 205             


Leu Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val 
    210                 215                 220                 


His Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr 
225                 230                 235                 240 


Leu Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp 
                245                 250                 255     


Leu Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro 
            260                 265                 270         


Pro Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys 
        275                 280                 285             


Val Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu 
    290                 295                 300                 


Ile Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala 
305                 310                 315                 320 


Gln Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu 
                325                 330                 335     


Pro Pro Ser Ala Leu Gln Ser Val Ala 
            340                 345 


<210>  988
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AURKC__Homo_sapiens__NP_001015878

<400>  988

Met Ser Ser Pro Arg Ala Val Val Gln Leu Gly Lys Ala Gln Pro Ala 
1               5                   10                  15      


Gly Glu Glu Leu Ala Thr Ala Asn Gln Thr Ala Gln Gln Pro Ser Ser 
            20                  25                  30          


Pro Ala Met Arg Arg Leu Thr Val Asp Asp Phe Glu Ile Gly Arg Pro 
        35                  40                  45              


Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Leu Lys Glu 
    50                  55                  60                  


Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln Ile Glu 
65                  70                  75                  80  


Lys Glu Gly Leu Glu His Gln Leu Arg Arg Glu Ile Glu Ile Gln Ala 
                85                  90                  95      


His Leu Gln His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe His Asp 
            100                 105                 110         


Ala Arg Arg Val Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly Glu Leu 
        115                 120                 125             


Tyr Lys Glu Leu Gln Lys Ser Glu Lys Leu Asp Glu Gln Arg Thr Ala 
    130                 135                 140                 


Thr Ile Ile Glu Glu Leu Ala Asp Ala Leu Thr Tyr Cys His Asp Lys 
145                 150                 155                 160 


Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Gly Phe 
                165                 170                 175     


Arg Gly Glu Val Lys Ile Ala Asp Phe Gly Trp Ser Val His Thr Pro 
            180                 185                 190         


Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu Pro Pro 
        195                 200                 205             


Glu Met Ile Glu Gly Arg Thr Tyr Asp Glu Lys Val Asp Leu Trp Cys 
    210                 215                 220                 


Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Tyr Pro Pro Phe Glu 
225                 230                 235                 240 


Ser Ala Ser His Ser Glu Thr Tyr Arg Arg Ile Leu Lys Val Asp Val 
                245                 250                 255     


Arg Phe Pro Leu Ser Met Pro Leu Gly Ala Arg Asp Leu Ile Ser Arg 
            260                 265                 270         


Leu Leu Arg Tyr Gln Pro Leu Glu Arg Leu Pro Leu Ala Gln Ile Leu 
        275                 280                 285             


Lys His Pro Trp Val Gln Ala His Ser Arg Arg Val Leu Pro Pro Cys 
    290                 295                 300                 


Ala Gln Met Ala Ser 
305                 


<210>  989
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AUTS2__Homo_sapiens__NP_001120703

<400>  989

Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Leu Thr Asp Pro Phe Arg Pro Met Leu Arg Lys Pro Gly Lys 
    610                 615                 620                 


Trp Cys Ala Met His Val His Ile Ala Trp Gln Ile Tyr His His Gln 
625                 630                 635                 640 


Gln Lys Val Lys Lys Gln Met Gln Ser Asp Pro His Lys Leu Asp Phe 
                645                 650                 655     


Gly Leu Lys Pro Glu Phe Leu Ser Arg Pro Pro Gly Pro Ser Leu Phe 
            660                 665                 670         


Gly Ala Ile His His Pro His Asp Leu Ala Arg Pro Ser Thr Leu Phe 
        675                 680                 685             


Ser Ala Ala Gly Ala Ala His Pro Thr Gly Thr Pro Phe Gly Pro Pro 
    690                 695                 700                 


Pro His His Ser Asn Phe Leu Asn Pro Ala Ala His Leu Glu Pro Phe 
705                 710                 715                 720 


Asn Arg Pro Ser Thr Phe Thr Gly Leu Ala Ala Val Gly Gly Asn Ala 
                725                 730                 735     


Phe Gly Gly Leu Gly Asn Pro Ser Val Thr Pro Asn Ser Met Phe Gly 
            740                 745                 750         


His Lys Asp Gly Pro Ser Val Gln Asn Phe Ser Asn Pro His Glu Pro 
        755                 760                 765             


Trp Asn Arg Leu His Arg Thr Pro Pro Ser Phe Pro Thr Pro Pro Pro 
    770                 775                 780                 


Trp Leu Lys Pro Gly Glu Leu Glu Arg Ser Ala Ser Ala Ala Ala His 
785                 790                 795                 800 


Asp Arg Asp Arg Asp Val Asp Lys Arg Asp Ser Ser Val Ser Lys Asp 
                805                 810                 815     


Asp Lys Glu Arg Glu Ser Val Glu Lys Arg His Ser Ser His Pro Ser 
            820                 825                 830         


Pro Ala Pro Val Leu Pro Val Asn Ala Leu Gly His Thr Arg Ser Ser 
        835                 840                 845             


Thr Glu Gln Ile Arg Ala His Leu Asn Thr Glu Ala Arg Glu Lys Asp 
    850                 855                 860                 


Lys Pro Lys Glu Arg Glu Arg Asp His Ser Glu Ser Arg Lys Asp Leu 
865                 870                 875                 880 


Ala Ala Asp Glu His Lys Ala Lys Glu Gly His Leu Pro Glu Lys Asp 
                885                 890                 895     


Gly His Gly His Glu Gly Arg Ala Ala Gly Glu Glu Ala Lys Gln Leu 
            900                 905                 910         


Ala Arg Val Pro Ser Pro Tyr Val Arg Thr Pro Val Val Glu Ser Ala 
        915                 920                 925             


Arg Pro Asn Ser Thr Ser Ser Arg Glu Ala Glu Pro Arg Lys Gly Glu 
    930                 935                 940                 


Pro Ala Tyr Glu Asn Pro Lys Lys Ser Ser Glu Val Lys Val Lys Glu 
945                 950                 955                 960 


Glu Arg Lys Glu Asp His Asp Leu Pro Pro Glu Ala Pro Gln Thr His 
                965                 970                 975     


Arg Ala Ser Glu Pro Pro Pro Pro Asn Ser Ser Ser Ser Val His Pro 
            980                 985                 990         


Gly Pro Leu Ala Ser Met Pro Met  Thr Val Gly Val Thr  Gly Ile His 
        995                 1000                 1005             


Pro Met  Asn Ser Ile Ser Ser  Leu Asp Arg Thr Arg  Met Met Thr 
    1010                 1015                 1020             


Pro Phe  Met Gly Ile Ser Pro  Leu Pro Gly Gly Glu  Arg Phe Pro 
    1025                 1030                 1035             


Tyr Pro  Ser Phe His Trp Asp  Pro Ile Arg Asp Pro  Leu Arg Asp 
    1040                 1045                 1050             


Pro Tyr  Arg Glu Leu Asp Ile  His Arg Arg Asp Pro  Leu Gly Arg 
    1055                 1060                 1065             


Asp Phe  Leu Leu Arg Asn Asp  Pro Leu His Arg Leu  Ser Thr Pro 
    1070                 1075                 1080             


Arg Leu  Tyr Glu Ala Asp Arg  Ser Phe Arg Asp Arg  Glu Pro His 
    1085                 1090                 1095             


Asp Tyr  Ser His His His His  His His His His Pro  Leu Ser Val 
    1100                 1105                 1110             


Asp Pro  Arg Arg Glu His Glu  Arg Gly Gly His Leu  Asp Glu Arg 
    1115                 1120                 1125             


Glu Arg  Leu His Met Leu Arg  Glu Asp Tyr Glu His  Thr Arg Leu 
    1130                 1135                 1140             


His Ser  Val His Pro Ala Ser  Leu Asp Gly His Leu  Pro His Pro 
    1145                 1150                 1155             


Ser Leu  Ile Thr Pro Gly Leu  Pro Ser Met His Tyr  Pro Arg Ile 
    1160                 1165                 1170             


Ser Pro  Thr Ala Gly Asn Gln  Asn Gly Leu Leu Asn  Lys Thr Pro 
    1175                 1180                 1185             


Pro Thr  Ala Ala Leu Ser Ala  Pro Pro Pro Leu Ile  Ser Thr Leu 
    1190                 1195                 1200             


Gly Gly  Arg Pro Val Ser Pro  Arg Arg Thr Thr Pro  Leu Ser Ala 
    1205                 1210                 1215             


Glu Ile  Arg Glu Arg Pro Pro  Ser His Thr Leu Lys  Asp Ile Glu 
    1220                 1225                 1230             


Ala Arg  
    1235 


<210>  990
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AVEN__Homo_sapiens__NP_065104

<400>  990

Met Gln Ala Glu Arg Gly Ala Arg Gly Gly Arg Gly Arg Arg Pro Gly 
1               5                   10                  15      


Arg Gly Arg Pro Gly Gly Asp Arg His Ser Glu Arg Pro Gly Ala Ala 
            20                  25                  30          


Ala Ala Val Ala Arg Gly Gly Gly Gly Gly Gly Gly Gly Asp Gly Gly 
        35                  40                  45              


Gly Arg Arg Gly Arg Gly Arg Gly Arg Gly Phe Arg Gly Ala Arg Gly 
    50                  55                  60                  


Gly Arg Gly Gly Gly Gly Ala Pro Arg Gly Ser Arg Arg Glu Pro Gly 
65                  70                  75                  80  


Gly Trp Gly Ala Gly Ala Ser Ala Pro Val Glu Asp Asp Ser Asp Ala 
                85                  90                  95      


Glu Thr Tyr Gly Glu Glu Asn Asp Glu Gln Gly Asn Tyr Ser Lys Arg 
            100                 105                 110         


Lys Ile Val Ser Asn Trp Asp Arg Tyr Gln Asp Ile Glu Lys Glu Val 
        115                 120                 125             


Asn Asn Glu Ser Gly Glu Ser Gln Arg Gly Thr Asp Phe Ser Val Leu 
    130                 135                 140                 


Leu Ser Ser Ala Gly Asp Ser Phe Ser Gln Phe Arg Phe Ala Glu Glu 
145                 150                 155                 160 


Lys Glu Trp Asp Ser Glu Ala Ser Cys Pro Lys Gln Asn Ser Ala Phe 
                165                 170                 175     


Tyr Val Asp Ser Glu Leu Leu Val Arg Ala Leu Gln Glu Leu Pro Leu 
            180                 185                 190         


Cys Leu Arg Leu Asn Val Ala Ala Glu Leu Val Gln Gly Thr Val Pro 
        195                 200                 205             


Leu Glu Val Pro Gln Val Lys Pro Lys Arg Thr Asp Asp Gly Lys Gly 
    210                 215                 220                 


Leu Gly Met Gln Leu Lys Gly Pro Leu Gly Pro Gly Gly Arg Gly Pro 
225                 230                 235                 240 


Ile Phe Glu Leu Lys Ser Val Ala Ala Gly Cys Pro Val Leu Leu Gly 
                245                 250                 255     


Lys Asp Asn Pro Ser Pro Gly Pro Ser Arg Asp Ser Gln Lys Pro Thr 
            260                 265                 270         


Ser Pro Leu Gln Ser Ala Gly Asp His Leu Glu Glu Glu Leu Asp Leu 
        275                 280                 285             


Leu Leu Asn Leu Asp Ala Pro Ile Lys Glu Gly Asp Asn Ile Leu Pro 
    290                 295                 300                 


Asp Gln Thr Ser Gln Asp Leu Lys Ser Lys Glu Asp Gly Glu Val Val 
305                 310                 315                 320 


Gln Glu Glu Glu Val Cys Ala Lys Pro Ser Val Thr Glu Glu Lys Asn 
                325                 330                 335     


Met Glu Pro Glu Gln Pro Ser Thr Ser Lys Asn Val Thr Glu Glu Glu 
            340                 345                 350         


Leu Glu Asp Trp Leu Asp Ser Met Ile Ser 
        355                 360         


<210>  991
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AVP__Homo_sapiens__NP_000481

<400>  991

Met Pro Asp Thr Met Leu Pro Ala Cys Phe Leu Gly Leu Leu Ala Phe 
1               5                   10                  15      


Ser Ser Ala Cys Tyr Phe Gln Asn Cys Pro Arg Gly Gly Lys Arg Ala 
            20                  25                  30          


Met Ser Asp Leu Glu Leu Arg Gln Cys Leu Pro Cys Gly Pro Gly Gly 
        35                  40                  45              


Lys Gly Arg Cys Phe Gly Pro Ser Ile Cys Cys Ala Asp Glu Leu Gly 
    50                  55                  60                  


Cys Phe Val Gly Thr Ala Glu Ala Leu Arg Cys Gln Glu Glu Asn Tyr 
65                  70                  75                  80  


Leu Pro Ser Pro Cys Gln Ser Gly Gln Lys Ala Cys Gly Ser Gly Gly 
                85                  90                  95      


Arg Cys Ala Ala Phe Gly Val Cys Cys Asn Asp Glu Ser Cys Val Thr 
            100                 105                 110         


Glu Pro Glu Cys Arg Glu Gly Phe His Arg Arg Ala Arg Ala Ser Asp 
        115                 120                 125             


Arg Ser Asn Ala Thr Gln Leu Asp Gly Pro Ala Gly Ala Leu Leu Leu 
    130                 135                 140                 


Arg Leu Val Gln Leu Ala Gly Ala Pro Glu Pro Phe Glu Pro Ala Gln 
145                 150                 155                 160 


Pro Asp Ala Tyr 
                


<210>  992
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AVPI1__Homo_sapiens__NP_068378

<400>  992

Met Gly Thr Pro Ala Ser Val Val Ser Glu Pro Pro Pro Trp Gln Ala 
1               5                   10                  15      


Pro Ile Glu Ala Arg Gly Arg Lys Gln Ala Ser Ala Asn Ile Phe Gln 
            20                  25                  30          


Asp Ala Glu Leu Leu Gln Ile Gln Ala Leu Phe Gln Arg Ser Gly Asp 
        35                  40                  45              


Gln Leu Ala Glu Glu Arg Ala Gln Ile Ile Trp Glu Cys Ala Gly Asp 
    50                  55                  60                  


His Arg Val Ala Glu Ala Leu Lys Arg Leu Arg Arg Lys Arg Pro Pro 
65                  70                  75                  80  


Arg Gln Lys Pro Leu Gly His Ser Leu His His Cys Ser Arg Leu Arg 
                85                  90                  95      


Ile Leu Glu Pro His Ser Ala Leu Ala Asn Pro Gln Ser Ala Thr Glu 
            100                 105                 110         


Thr Ala Ser Ser Glu Gln Tyr Leu His Ser Arg Lys Lys Ser Ala Arg 
        115                 120                 125             


Ile Arg Arg Asn Trp Arg Lys Ser Gly Pro Thr Ser Tyr Leu His Gln 
    130                 135                 140                 


Ile Arg His 
145         


<210>  993
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AVPR1A__Homo_sapiens__NP_000697

<400>  993

Met Arg Leu Ser Ala Gly Pro Asp Ala Gly Pro Ser Gly Asn Ser Ser 
1               5                   10                  15      


Pro Trp Trp Pro Leu Ala Thr Gly Ala Gly Asn Thr Ser Arg Glu Ala 
            20                  25                  30          


Glu Ala Leu Gly Glu Gly Asn Gly Pro Pro Arg Asp Val Arg Asn Glu 
        35                  40                  45              


Glu Leu Ala Lys Leu Glu Ile Ala Val Leu Ala Val Thr Phe Ala Val 
    50                  55                  60                  


Ala Val Leu Gly Asn Ser Ser Val Leu Leu Ala Leu His Arg Thr Pro 
65                  70                  75                  80  


Arg Lys Thr Ser Arg Met His Leu Phe Ile Arg His Leu Ser Leu Ala 
                85                  90                  95      


Asp Leu Ala Val Ala Phe Phe Gln Val Leu Pro Gln Met Cys Trp Asp 
            100                 105                 110         


Ile Thr Tyr Arg Phe Arg Gly Pro Asp Trp Leu Cys Arg Val Val Lys 
        115                 120                 125             


His Leu Gln Val Phe Gly Met Phe Ala Ser Ala Tyr Met Leu Val Val 
    130                 135                 140                 


Met Thr Ala Asp Arg Tyr Ile Ala Val Cys His Pro Leu Lys Thr Leu 
145                 150                 155                 160 


Gln Gln Pro Ala Arg Arg Ser Arg Leu Met Ile Ala Ala Ala Trp Val 
                165                 170                 175     


Leu Ser Phe Val Leu Ser Thr Pro Gln Tyr Phe Val Phe Ser Met Ile 
            180                 185                 190         


Glu Val Asn Asn Val Thr Lys Ala Arg Asp Cys Trp Ala Thr Phe Ile 
        195                 200                 205             


Gln Pro Trp Gly Ser Arg Ala Tyr Val Thr Trp Met Thr Gly Gly Ile 
    210                 215                 220                 


Phe Val Ala Pro Val Val Ile Leu Gly Thr Cys Tyr Gly Phe Ile Cys 
225                 230                 235                 240 


Tyr Asn Ile Trp Cys Asn Val Arg Gly Lys Thr Ala Ser Arg Gln Ser 
                245                 250                 255     


Lys Gly Ala Glu Gln Ala Gly Val Ala Phe Gln Lys Gly Phe Leu Leu 
            260                 265                 270         


Ala Pro Cys Val Ser Ser Val Lys Ser Ile Ser Arg Ala Lys Ile Arg 
        275                 280                 285             


Thr Val Lys Met Thr Phe Val Ile Val Thr Ala Tyr Ile Val Cys Trp 
    290                 295                 300                 


Ala Pro Phe Phe Ile Ile Gln Met Trp Ser Val Trp Asp Pro Met Ser 
305                 310                 315                 320 


Val Trp Thr Glu Ser Glu Asn Pro Thr Ile Thr Ile Thr Ala Leu Leu 
                325                 330                 335     


Gly Ser Leu Asn Ser Cys Cys Asn Pro Trp Ile Tyr Met Phe Phe Ser 
            340                 345                 350         


Gly His Leu Leu Gln Asp Cys Val Gln Ser Phe Pro Cys Cys Gln Asn 
        355                 360                 365             


Met Lys Glu Lys Phe Asn Lys Glu Asp Thr Asp Ser Met Ser Arg Arg 
    370                 375                 380                 


Gln Thr Phe Tyr Ser Asn Asn Arg Ser Pro Thr Asn Ser Thr Gly Met 
385                 390                 395                 400 


Trp Lys Asp Ser Pro Lys Ser Ser Lys Ser Ile Lys Phe Ile Pro Val 
                405                 410                 415     


Ser Thr 
        


<210>  994
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AVPR1B__Homo_sapiens__NP_000698

<400>  994

Met Asp Ser Gly Pro Leu Trp Asp Ala Asn Pro Thr Pro Arg Gly Thr 
1               5                   10                  15      


Leu Ser Ala Pro Asn Ala Thr Thr Pro Trp Leu Gly Arg Asp Glu Glu 
            20                  25                  30          


Leu Ala Lys Val Glu Ile Gly Val Leu Ala Thr Val Leu Val Leu Ala 
        35                  40                  45              


Thr Gly Gly Asn Leu Ala Val Leu Leu Thr Leu Gly Gln Leu Gly Arg 
    50                  55                  60                  


Lys Arg Ser Arg Met His Leu Phe Val Leu His Leu Ala Leu Thr Asp 
65                  70                  75                  80  


Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln Leu Leu Trp Asp Ile 
                85                  90                  95      


Thr Tyr Arg Phe Gln Gly Pro Asp Leu Leu Cys Arg Ala Val Lys Tyr 
            100                 105                 110         


Leu Gln Val Leu Ser Met Phe Ala Ser Thr Tyr Met Leu Leu Ala Met 
        115                 120                 125             


Thr Leu Asp Arg Tyr Leu Ala Val Cys His Pro Leu Arg Ser Leu Gln 
    130                 135                 140                 


Gln Pro Gly Gln Ser Thr Tyr Leu Leu Ile Ala Ala Pro Trp Leu Leu 
145                 150                 155                 160 


Ala Ala Ile Phe Ser Leu Pro Gln Val Phe Ile Phe Ser Leu Arg Glu 
                165                 170                 175     


Val Ile Gln Gly Ser Gly Val Leu Asp Cys Trp Ala Asp Phe Gly Phe 
            180                 185                 190         


Pro Trp Gly Pro Arg Ala Tyr Leu Thr Trp Thr Thr Leu Ala Ile Phe 
        195                 200                 205             


Val Leu Pro Val Thr Met Leu Thr Ala Cys Tyr Ser Leu Ile Cys His 
    210                 215                 220                 


Glu Ile Cys Lys Asn Leu Lys Val Lys Thr Gln Ala Trp Arg Val Gly 
225                 230                 235                 240 


Gly Gly Gly Trp Arg Thr Trp Asp Arg Pro Ser Pro Ser Thr Leu Ala 
                245                 250                 255     


Ala Thr Thr Arg Gly Leu Pro Ser Arg Val Ser Ser Ile Asn Thr Ile 
            260                 265                 270         


Ser Arg Ala Lys Ile Arg Thr Val Lys Met Thr Phe Val Ile Val Leu 
        275                 280                 285             


Ala Tyr Ile Ala Cys Trp Ala Pro Phe Phe Ser Val Gln Met Trp Ser 
    290                 295                 300                 


Val Trp Asp Lys Asn Ala Pro Asp Glu Asp Ser Thr Asn Val Ala Phe 
305                 310                 315                 320 


Thr Ile Ser Met Leu Leu Gly Asn Leu Asn Ser Cys Cys Asn Pro Trp 
                325                 330                 335     


Ile Tyr Met Gly Phe Asn Ser His Leu Leu Pro Arg Pro Leu Arg His 
            340                 345                 350         


Leu Ala Cys Cys Gly Gly Pro Gln Pro Arg Met Arg Arg Arg Leu Ser 
        355                 360                 365             


Asp Gly Ser Leu Ser Ser Arg His Thr Thr Leu Leu Thr Arg Ser Ser 
    370                 375                 380                 


Cys Pro Ala Thr Leu Ser Leu Ser Leu Ser Leu Thr Leu Ser Gly Arg 
385                 390                 395                 400 


Pro Arg Pro Glu Glu Ser Pro Arg Asp Leu Glu Leu Ala Asp Gly Glu 
                405                 410                 415     


Gly Thr Ala Glu Thr Ile Ile Phe 
            420                 


<210>  995
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AVPR2__Homo_sapiens__NP_001139623

<400>  995

Met Leu Met Ala Ser Thr Thr Ser Ala Val Pro Gly His Pro Ser Leu 
1               5                   10                  15      


Pro Ser Leu Pro Ser Asn Ser Ser Gln Glu Arg Pro Leu Asp Thr Arg 
            20                  25                  30          


Asp Pro Leu Leu Ala Arg Ala Glu Leu Ala Leu Leu Ser Ile Val Phe 
        35                  40                  45              


Val Ala Val Ala Leu Ser Asn Gly Leu Val Leu Ala Ala Leu Ala Arg 
    50                  55                  60                  


Arg Gly Arg Arg Gly His Trp Ala Pro Ile His Val Phe Ile Gly His 
65                  70                  75                  80  


Leu Cys Leu Ala Asp Leu Ala Val Ala Leu Phe Gln Val Leu Pro Gln 
                85                  90                  95      


Leu Ala Trp Lys Ala Thr Asp Arg Phe Arg Gly Pro Asp Ala Leu Cys 
            100                 105                 110         


Arg Ala Val Lys Tyr Leu Gln Met Val Gly Met Tyr Ala Ser Ser Tyr 
        115                 120                 125             


Met Ile Leu Ala Met Thr Leu Asp Arg His Arg Ala Ile Cys Arg Pro 
    130                 135                 140                 


Met Leu Ala Tyr Arg His Gly Ser Gly Ala His Trp Asn Arg Pro Val 
145                 150                 155                 160 


Leu Val Ala Trp Ala Phe Ser Leu Leu Leu Ser Leu Pro Gln Leu Phe 
                165                 170                 175     


Ile Phe Ala Gln Arg Asn Val Glu Gly Gly Ser Gly Val Thr Asp Cys 
            180                 185                 190         


Trp Ala Cys Phe Ala Glu Pro Trp Gly Arg Arg Thr Tyr Val Thr Trp 
        195                 200                 205             


Ile Ala Leu Met Val Phe Val Ala Pro Thr Leu Gly Ile Ala Ala Cys 
    210                 215                 220                 


Gln Val Leu Ile Phe Arg Glu Ile His Ala Ser Leu Val Pro Gly Pro 
225                 230                 235                 240 


Ser Glu Arg Pro Gly Gly Arg Arg Arg Gly Arg Arg Thr Gly Ser Pro 
                245                 250                 255     


Gly Glu Gly Ala His Val Ser Ala Ala Val Ala Lys Thr Val Arg Met 
            260                 265                 270         


Thr Leu Val Ile Val Val Val Tyr Val Leu Cys Trp Ala Pro Phe Phe 
        275                 280                 285             


Leu Val Gln Leu Trp Ala Ala Trp Asp Pro Glu Ala Pro Leu Glu Gly 
    290                 295                 300                 


Gly Cys Ser Arg Gly 
305                 


<210>  996
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AWAT1__Homo_sapiens__NP_001013597

<400>  996

Met Ala His Ser Lys Gln Pro Ser His Phe Gln Ser Leu Met Leu Leu 
1               5                   10                  15      


Gln Trp Pro Leu Ser Tyr Leu Ala Ile Phe Trp Ile Leu Gln Pro Leu 
            20                  25                  30          


Phe Val Tyr Leu Leu Phe Thr Ser Leu Trp Pro Leu Pro Val Leu Tyr 
        35                  40                  45              


Phe Ala Trp Leu Phe Leu Asp Trp Lys Thr Pro Glu Arg Gly Gly Arg 
    50                  55                  60                  


Arg Ser Ala Trp Val Arg Asn Trp Cys Val Trp Thr His Ile Arg Asp 
65                  70                  75                  80  


Tyr Phe Pro Ile Thr Ile Leu Lys Thr Lys Asp Leu Ser Pro Glu His 
                85                  90                  95      


Asn Tyr Leu Met Gly Val His Pro His Gly Leu Leu Thr Phe Gly Ala 
            100                 105                 110         


Phe Cys Asn Phe Cys Thr Glu Ala Thr Gly Phe Ser Lys Thr Phe Pro 
        115                 120                 125             


Gly Ile Thr Pro His Leu Ala Thr Leu Ser Trp Phe Phe Lys Ile Pro 
    130                 135                 140                 


Phe Val Arg Glu Tyr Leu Met Ala Lys Gly Val Cys Ser Val Ser Gln 
145                 150                 155                 160 


Pro Ala Ile Asn Tyr Leu Leu Ser His Gly Thr Gly Asn Leu Val Gly 
                165                 170                 175     


Ile Val Val Gly Gly Val Gly Glu Ala Leu Gln Ser Val Pro Asn Thr 
            180                 185                 190         


Thr Thr Leu Ile Leu Gln Lys Arg Lys Gly Phe Val Arg Thr Ala Leu 
        195                 200                 205             


Gln His Gly Ala His Leu Val Pro Thr Phe Thr Phe Gly Glu Thr Glu 
    210                 215                 220                 


Val Tyr Asp Gln Val Leu Phe His Lys Asp Ser Arg Met Tyr Lys Phe 
225                 230                 235                 240 


Gln Ser Cys Phe Arg Arg Ile Phe Gly Phe Tyr Cys Cys Val Phe Tyr 
                245                 250                 255     


Gly Gln Ser Phe Cys Gln Gly Ser Thr Gly Leu Leu Pro Tyr Ser Arg 
            260                 265                 270         


Pro Ile Val Thr Val Val Gly Glu Pro Leu Pro Leu Pro Gln Ile Glu 
        275                 280                 285             


Lys Pro Ser Gln Glu Met Val Asp Lys Tyr His Ala Leu Tyr Met Asp 
    290                 295                 300                 


Ala Leu His Lys Leu Phe Asp Gln His Lys Thr His Tyr Gly Cys Ser 
305                 310                 315                 320 


Glu Thr Gln Lys Leu Phe Phe Leu 
                325             


<210>  997
<211>  1012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXDND1__Homo_sapiens__NP_653297

<400>  997

Met Ser Leu Pro Lys Thr Pro Ser Thr Pro Leu Asn Ser Thr Ser Thr 
1               5                   10                  15      


Ser Glu Ser Lys Lys Leu Lys Val Ser Val Ala Lys Glu Gly Thr Arg 
            20                  25                  30          


Gly Leu Pro Glu Leu Lys Glu Lys Lys Asn Met Val Asp Arg Ser Lys 
        35                  40                  45              


Leu Leu Pro Thr Ser Leu Gln Asn Glu Phe Ile Pro Lys Glu Val Leu 
    50                  55                  60                  


Leu Ser Leu Thr Tyr Ala Ala Asn Ala Gly Pro Cys Pro Glu Asn Leu 
65                  70                  75                  80  


Leu Pro Pro Lys Lys Ile Lys Thr Pro Lys Gly Thr Leu Pro Arg Leu 
                85                  90                  95      


Val Asp His Val Trp His His Pro Val Arg Arg Asn Lys Phe Lys Tyr 
            100                 105                 110         


Leu Ile Asp His Pro Val Ser Leu Thr Gly Ala Gly Arg Asp Ile Ser 
        115                 120                 125             


Phe Leu Tyr Asp Val Thr Tyr Ala Lys Gly Gln Thr Arg Glu Lys Ala 
    130                 135                 140                 


Val Cys Pro Pro His Leu Ala Arg Ser Leu Gln Ser His Asp Gly Val 
145                 150                 155                 160 


Ile Val Pro His Lys Pro Lys Thr Leu Thr Asp Thr Leu Ile Pro Glu 
                165                 170                 175     


Glu Phe His Ile Val Ser Ser Thr Gly Val Ser Gly Leu Glu Cys Tyr 
            180                 185                 190         


Asp Asp Lys Tyr Thr Thr Leu Leu Thr Asp Ser Glu Asn Arg Leu Leu 
        195                 200                 205             


Leu Phe Pro Ser Met Lys Pro Asn Lys Arg Val Glu Val Ala Gln Leu 
    210                 215                 220                 


Asn Asp Val Met Asp Thr Met Leu Glu Arg Ala Gly Val Glu Asn Gln 
225                 230                 235                 240 


Glu Tyr Thr Gly Pro Thr Lys Met His Lys Leu Leu His Ile Leu Lys 
                245                 250                 255     


Lys Glu Gln Thr Ile Tyr Asn Met Ile Phe His Glu Leu Ile Arg Gln 
            260                 265                 270         


Val Ser Val Asp Cys Ala Asp Arg Gly Glu Leu Leu Ser Lys Val Arg 
        275                 280                 285             


Glu Arg Tyr Val Gln Met Leu Asp Gln Ile Ala Arg Gln Met Ile Asp 
    290                 295                 300                 


Phe Tyr Lys Asp Leu Val Thr Gln Arg Val Met Asp Gln Arg Ile Leu 
305                 310                 315                 320 


Glu Glu Leu Tyr Asn Phe Lys His Val Ile Glu Glu Leu Thr Arg Glu 
                325                 330                 335     


Leu Cys Leu Val Arg Ala His Asp Val Lys Leu Thr Lys Glu Thr Glu 
            340                 345                 350         


Lys Ala His Lys Asp Leu Ala Gln Ala Leu Leu Asn Ala Glu Lys Asn 
        355                 360                 365             


Ala Lys Ile Val Glu Glu Tyr His Asp Leu Tyr Thr Leu Gln Arg Glu 
    370                 375                 380                 


Arg Met Glu Asn Asp Met Lys Lys Leu Val Ala Glu Arg Asp Ile Trp 
385                 390                 395                 400 


Ser Ser Ala Thr Tyr Glu Leu Ala Leu Lys Val Ile Glu Arg Asn Arg 
                405                 410                 415     


Val Ile Leu Ala Arg Arg Leu Tyr Leu Asn Glu Lys Gly Trp Asn Lys 
            420                 425                 430         


Tyr Thr Lys His Phe Ile Ile Leu Leu Ser Asn Lys Asp Thr Glu Asp 
        435                 440                 445             


Leu Ala Leu Leu Gln Lys Leu Thr Gln Lys Trp Arg Asn Leu Val Asn 
    450                 455                 460                 


Lys Leu Lys Gln Glu Val Glu Gln Met Glu Glu Ser Thr Ser Glu Thr 
465                 470                 475                 480 


Leu Lys Ile Val Lys Asp Gly Leu Ile Lys Trp Gln Glu Phe Phe Asn 
                485                 490                 495     


Glu Lys Asp Ile Leu Ser Pro Asn Lys Gly Asn Ile Phe Asn Ser Val 
            500                 505                 510         


Leu Leu Asp Phe Lys Gln Trp Gln Lys Ile Leu Asn Glu Lys Lys Glu 
        515                 520                 525             


Glu Phe Thr Gly Asp Val Leu Leu Ser Lys Tyr Asp Thr Leu Lys Ile 
    530                 535                 540                 


Ile Lys His Leu Gln Glu Asn Trp Ala Asp Ile Gly Leu Gly Ile Phe 
545                 550                 555                 560 


Asn Arg His Lys Ser Leu Glu Gly Glu Met Pro Ser Glu Arg Gln Tyr 
                565                 570                 575     


Met Glu Glu Ile Ile Lys Asn Ile Gln Lys Leu Tyr Lys Glu Tyr Glu 
            580                 585                 590         


Ile Arg Ile Asn Gly Asp Asn Gly Tyr Ser Lys Ile Leu Pro Ser Leu 
        595                 600                 605             


Ile Ser Ser Leu Asp Phe Cys Ser Phe Lys Leu Glu Asn Leu Glu Phe 
    610                 615                 620                 


Pro Asp Thr Pro Leu Glu Glu Trp Gln Glu Ile Asp Glu Lys Ile Asn 
625                 630                 635                 640 


Glu Met Lys Ser His Leu Asp Ile Leu Leu Asn Leu Thr Gly Ile Val 
                645                 650                 655     


Pro Gln His Ile Asp Val Asp Ser Val Ser Val Leu Gln Ala Tyr Ile 
            660                 665                 670         


Phe Asn Met Ile Gln Gln Trp Leu Leu Lys Ile Gly Asn Glu Ile Asn 
        675                 680                 685             


Asn Gly Asn Ile Glu Leu Gln His His Met Asp Glu Leu His Ile Ser 
    690                 695                 700                 


Met Ile Gln Trp Met Val Asn Leu Leu Ile Leu Met Ile Pro Asn Phe 
705                 710                 715                 720 


Thr Asp Gln Asp Cys Leu Leu Lys Leu Glu Glu Glu Ser Ala Glu Lys 
                725                 730                 735     


His Asp Ile Gly Val Ala Arg Leu Glu Leu Asp Ala Ile Glu Leu Thr 
            740                 745                 750         


Arg Lys Leu Tyr Gln Tyr Ser Ser Tyr Leu Ser Ser Cys Cys Lys Gly 
        755                 760                 765             


Met Val Thr Ala Met Ala Leu Ser Lys Ser Thr Asn Ser His Lys Asn 
    770                 775                 780                 


Ala Thr Glu Asp Leu Tyr Glu Val Asp Lys Leu Lys Lys Glu Cys Tyr 
785                 790                 795                 800 


Glu Trp Ile Asn Thr Cys Ser Cys Leu Leu Ser Asn Ile Lys Gly Arg 
                805                 810                 815     


Lys Ile Thr Leu Leu Thr Tyr Glu Glu Ile Glu Arg Leu Leu Glu Glu 
            820                 825                 830         


Glu Ala Val Lys Glu Phe Ile Glu Pro Glu Ile Asp Glu Ser Phe Lys 
        835                 840                 845             


Glu Asp Glu Glu Glu Ser Lys Glu Asp Arg Lys Leu Gln Glu Glu Asn 
    850                 855                 860                 


Lys Glu Arg Ala Glu Glu Gln Pro Ser Thr Ser Thr Glu Lys Glu Lys 
865                 870                 875                 880 


Leu Ile Arg Phe Ile Gly Glu Asp Glu Asn Val His Ser Lys Pro Leu 
                885                 890                 895     


Phe Glu Thr Asp Val Leu Ser Ser Trp Arg Glu Ser Ala Lys Gln Gly 
            900                 905                 910         


Thr Leu Ala Gln Lys Tyr Leu Glu Ala Met Ala Val Ile Glu His Met 
        915                 920                 925             


Gln Glu Lys Leu Leu Glu Val Glu Asn Arg Ala Arg Gln Ala Glu Glu 
    930                 935                 940                 


Lys Phe Glu Asp Ala Tyr Glu Lys Leu His His Thr Leu Ile Lys Asn 
945                 950                 955                 960 


Lys Asp Leu Glu Glu Leu Val Met Thr Ser Arg Lys Glu Ser Lys Glu 
                965                 970                 975     


Glu Lys Glu Asn Gln Asp Glu Arg Glu Val Lys Glu Glu Glu Glu Gln 
            980                 985                 990         


Gln Glu Glu Glu Glu Val Arg Ser  Ala Glu Asn Ser Ser  Lys Ser Pro 
        995                 1000                 1005             


Lys Lys  Gly His 
    1010         


<210>  998
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXIN1__Homo_sapiens__NP_003493

<400>  998

Met Asn Ile Gln Glu Gln Gly Phe Pro Leu Asp Leu Gly Ala Ser Phe 
1               5                   10                  15      


Thr Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu Leu 
            20                  25                  30          


Val Ser Thr Asp Pro Arg Pro Ala Ser Tyr Ser Phe Cys Ser Gly Lys 
        35                  40                  45              


Gly Val Gly Ile Lys Gly Glu Thr Ser Thr Ala Thr Pro Arg Arg Ser 
    50                  55                  60                  


Asp Leu Asp Leu Gly Tyr Glu Pro Glu Gly Ser Ala Ser Pro Thr Pro 
65                  70                  75                  80  


Pro Tyr Leu Lys Trp Ala Glu Ser Leu His Ser Leu Leu Asp Asp Gln 
                85                  90                  95      


Asp Gly Ile Ser Leu Phe Arg Thr Phe Leu Lys Gln Glu Gly Cys Ala 
            100                 105                 110         


Asp Leu Leu Asp Phe Trp Phe Ala Cys Thr Gly Phe Arg Lys Leu Glu 
        115                 120                 125             


Pro Cys Asp Ser Asn Glu Glu Lys Arg Leu Lys Leu Ala Arg Ala Ile 
    130                 135                 140                 


Tyr Arg Lys Tyr Ile Leu Asp Asn Asn Gly Ile Val Ser Arg Gln Thr 
145                 150                 155                 160 


Lys Pro Ala Thr Lys Ser Phe Ile Lys Gly Cys Ile Met Lys Gln Leu 
                165                 170                 175     


Ile Asp Pro Ala Met Phe Asp Gln Ala Gln Thr Glu Ile Gln Ala Thr 
            180                 185                 190         


Met Glu Glu Asn Thr Tyr Pro Ser Phe Leu Lys Ser Asp Ile Tyr Leu 
        195                 200                 205             


Glu Tyr Thr Arg Thr Gly Ser Glu Ser Pro Lys Val Cys Ser Asp Gln 
    210                 215                 220                 


Ser Ser Gly Ser Gly Thr Gly Lys Gly Ile Ser Gly Tyr Leu Pro Thr 
225                 230                 235                 240 


Leu Asn Glu Asp Glu Glu Trp Lys Cys Asp Gln Asp Met Asp Glu Asp 
                245                 250                 255     


Asp Gly Arg Asp Ala Ala Pro Pro Gly Arg Leu Pro Gln Lys Leu Leu 
            260                 265                 270         


Leu Glu Thr Ala Ala Pro Arg Val Ser Ser Ser Arg Arg Tyr Ser Glu 
        275                 280                 285             


Gly Arg Glu Phe Arg Tyr Gly Ser Trp Arg Glu Pro Val Asn Pro Tyr 
    290                 295                 300                 


Tyr Val Asn Ala Gly Tyr Ala Leu Ala Pro Ala Thr Ser Ala Asn Asp 
305                 310                 315                 320 


Ser Glu Gln Gln Ser Leu Ser Ser Asp Ala Asp Thr Leu Ser Leu Thr 
                325                 330                 335     


Asp Ser Ser Val Asp Gly Ile Pro Pro Tyr Arg Ile Arg Lys Gln His 
            340                 345                 350         


Arg Arg Glu Met Gln Glu Ser Val Gln Val Asn Gly Arg Val Pro Leu 
        355                 360                 365             


Pro His Ile Pro Arg Thr Tyr Arg Val Pro Lys Glu Val Arg Val Glu 
    370                 375                 380                 


Pro Gln Lys Phe Ala Glu Glu Leu Ile His Arg Leu Glu Ala Val Gln 
385                 390                 395                 400 


Arg Thr Arg Glu Ala Glu Glu Lys Leu Glu Glu Arg Leu Lys Arg Val 
                405                 410                 415     


Arg Met Glu Glu Glu Gly Glu Asp Gly Asp Pro Ser Ser Gly Pro Pro 
            420                 425                 430         


Gly Pro Cys His Lys Leu Pro Pro Ala Pro Ala Trp His His Phe Pro 
        435                 440                 445             


Pro Arg Cys Val Asp Met Gly Cys Ala Gly Leu Arg Asp Ala His Glu 
    450                 455                 460                 


Glu Asn Pro Glu Ser Ile Leu Asp Glu His Val Gln Arg Val Leu Arg 
465                 470                 475                 480 


Thr Pro Gly Arg Gln Ser Pro Gly Pro Gly His Arg Ser Pro Asp Ser 
                485                 490                 495     


Gly His Val Ala Lys Met Pro Val Ala Leu Gly Gly Ala Ala Ser Gly 
            500                 505                 510         


His Gly Lys His Val Pro Lys Ser Gly Ala Lys Leu Asp Ala Ala Gly 
        515                 520                 525             


Leu His His His Arg His Val His His His Val His His Ser Thr Ala 
    530                 535                 540                 


Arg Pro Lys Glu Gln Val Glu Ala Glu Ala Thr Arg Arg Ala Gln Ser 
545                 550                 555                 560 


Ser Phe Ala Trp Gly Leu Glu Pro His Ser His Gly Ala Arg Ser Arg 
                565                 570                 575     


Gly Tyr Ser Glu Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu 
            580                 585                 590         


Ala His Ser Gly Lys Val Gly Val Ala Cys Lys Arg Asn Ala Lys Lys 
        595                 600                 605             


Ala Glu Ser Gly Lys Ser Ala Ser Thr Glu Val Pro Gly Ala Ser Glu 
    610                 615                 620                 


Asp Ala Glu Lys Asn Gln Lys Ile Met Gln Trp Ile Ile Glu Gly Glu 
625                 630                 635                 640 


Lys Glu Ile Ser Arg His Arg Arg Thr Gly His Gly Ser Ser Gly Thr 
                645                 650                 655     


Arg Lys Pro Gln Pro His Glu Asn Ser Arg Pro Leu Ser Leu Glu His 
            660                 665                 670         


Pro Trp Ala Gly Pro Gln Leu Arg Thr Ser Val Gln Pro Ser His Leu 
        675                 680                 685             


Phe Ile Gln Asp Pro Thr Met Pro Pro His Pro Ala Pro Asn Pro Leu 
    690                 695                 700                 


Thr Gln Leu Glu Glu Ala Arg Arg Arg Leu Glu Glu Glu Glu Lys Arg 
705                 710                 715                 720 


Ala Ser Arg Ala Pro Ser Lys Gln Arg Tyr Val Gln Glu Val Met Arg 
                725                 730                 735     


Arg Gly Arg Ala Cys Val Arg Pro Ala Cys Ala Pro Val Leu His Val 
            740                 745                 750         


Val Pro Ala Val Ser Asp Met Glu Leu Ser Glu Thr Glu Thr Arg Ser 
        755                 760                 765             


Gln Arg Lys Val Gly Gly Gly Ser Ala Gln Pro Cys Asp Ser Ile Val 
    770                 775                 780                 


Val Ala Tyr Tyr Phe Cys Gly Glu Pro Ile Pro Tyr Arg Thr Leu Val 
785                 790                 795                 800 


Arg Gly Arg Ala Val Thr Leu Gly Gln Phe Lys Glu Leu Leu Thr Lys 
                805                 810                 815     


Lys Gly Ser Tyr Arg Tyr Tyr Phe Lys Lys Val Ser Asp Glu Phe Asp 
            820                 825                 830         


Cys Gly Val Val Phe Glu Glu Val Arg Glu Asp Glu Ala Val Leu Pro 
        835                 840                 845             


Val Phe Glu Glu Lys Ile Ile Gly Lys Val Glu Lys Val Asp 
    850                 855                 860         


<210>  999
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXIN2__Homo_sapiens__XP_011523623

<400>  999

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Pro Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Thr Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Thr Leu Asn Glu Glu Glu Glu Trp Thr Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Thr Val Val Gly Leu Ser Ser Lys Thr Leu Arg 
                245                 250                 255     


Ala Thr Ala Ser Val Arg Ser Thr Glu Thr Val Asp Ser Gly Tyr Arg 
            260                 265                 270         


Ser Phe Lys Arg Ser Asp Pro Val Asn Pro Tyr His Ile Gly Ser Gly 
        275                 280                 285             


Tyr Val Phe Ala Pro Ala Thr Ser Ala Asn Asp Ser Glu Ile Ser Ser 
    290                 295                 300                 


Asp Ala Leu Thr Asp Asp Ser Met Ser Met Thr Asp Ser Ser Val Asp 
305                 310                 315                 320 


Gly Ile Pro Pro Tyr Arg Val Gly Ser Lys Lys Gln Leu Gln Arg Glu 
                325                 330                 335     


Met His Arg Ser Val Lys Ala Asn Gly Gln Val Ser Leu Pro His Phe 
            340                 345                 350         


Pro Arg Thr His Arg Leu Pro Lys Glu Met Thr Pro Val Glu Pro Ala 
        355                 360                 365             


Thr Phe Ala Ala Glu Leu Ile Ser Arg Leu Glu Lys Leu Lys Leu Glu 
    370                 375                 380                 


Leu Glu Ser Arg His Ser Leu Glu Glu Arg Leu Gln Gln Ile Arg Glu 
385                 390                 395                 400 


Asp Glu Glu Arg Glu Gly Ser Glu Leu Thr Leu Asn Ser Arg Glu Gly 
                405                 410                 415     


Ala Pro Thr Gln His Pro Leu Ser Leu Leu Pro Ser Gly Ser Tyr Glu 
            420                 425                 430         


Glu Asp Pro Gln Thr Ile Leu Asp Asp His Leu Ser Arg Val Leu Lys 
        435                 440                 445             


Thr Pro Gly Cys Gln Ser Pro Gly Val Gly Arg Tyr Ser Pro Arg Ser 
    450                 455                 460                 


Arg Ser Pro Asp His His His His His His Ser Gln Tyr His Ser Leu 
465                 470                 475                 480 


Leu Pro Pro Gly Gly Lys Leu Pro Pro Ala Ala Ala Ser Pro Gly Ala 
                485                 490                 495     


Cys Pro Leu Leu Gly Gly Lys Gly Phe Val Thr Lys Gln Thr Thr Lys 
            500                 505                 510         


His Val His His His Tyr Ile His His His Ala Val Pro Lys Thr Lys 
        515                 520                 525             


Glu Glu Ile Glu Ala Glu Ala Thr Gln Arg Val His Cys Phe Cys Pro 
    530                 535                 540                 


Gly Gly Ser Glu Tyr Tyr Cys Tyr Ser Lys Cys Lys Ser His Ser Lys 
545                 550                 555                 560 


Ala Pro Glu Thr Met Pro Ser Glu Gln Phe Gly Gly Ser Arg Gly Ser 
                565                 570                 575     


Thr Leu Pro Lys Arg Asn Gly Lys Gly Thr Glu Pro Gly Leu Ala Leu 
            580                 585                 590         


Pro Ala Arg Glu Gly Gly Ala Pro Gly Gly Ala Gly Ala Leu Gln Leu 
        595                 600                 605             


Pro Arg Glu Glu Gly Asp Arg Ser Gln Asp Val Trp Gln Trp Met Leu 
    610                 615                 620                 


Glu Ser Glu Arg Gln Ser Lys Pro Lys Pro His Ser Ala Gln Ser Thr 
625                 630                 635                 640 


Lys Lys Ala Tyr Pro Leu Glu Ser Ala Arg Ser Ser Pro Gly Glu Arg 
                645                 650                 655     


Ala Ser Arg His His Leu Trp Gly Gly Asn Ser Gly His Pro Arg Thr 
            660                 665                 670         


Thr Pro Arg Ala His Leu Phe Thr Gln Asp Pro Ala Met Pro Pro Leu 
        675                 680                 685             


Thr Pro Pro Asn Thr Leu Ala Gln Leu Glu Glu Ala Cys Arg Arg Leu 
    690                 695                 700                 


Ala Glu Val Ser Lys Pro Pro Lys Gln Arg Cys Cys Val Ala Ser Gln 
705                 710                 715                 720 


Gln Arg Asp Arg Asn His Ser Ala Thr Val Gln Thr Gly Ala Thr Pro 
                725                 730                 735     


Phe Ser Asn Pro Ser Leu Ala Pro Glu Asp His Lys Glu Pro Lys Lys 
            740                 745                 750         


Leu Ala Gly Val His Ala Leu Gln Ala Ser Glu Leu Val Val Thr Tyr 
        755                 760                 765             


Phe Phe Cys Gly Glu Glu Ile Pro Tyr Arg Arg Met Leu Lys Ala Gln 
    770                 775                 780                 


Ser Leu Thr Leu Gly His Phe Lys Glu Gln Leu Ser Lys Lys Gly Asn 
785                 790                 795                 800 


Tyr Arg Tyr Tyr Phe Lys Lys Ala Ser Asp Glu Phe Ala Cys Gly Ala 
                805                 810                 815     


Val Phe Glu Glu Ile Trp Glu Asp Glu Thr Val Leu Pro Met Tyr Glu 
            820                 825                 830         


Gly Arg Ile Leu Gly Lys Val Glu Arg Ile Asp 
        835                 840             


<210>  1000
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXL__Homo_sapiens__NP_001690

<400>  1000

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  1001
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AZGP1__Homo_sapiens__NP_001176

<400>  1001

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  1002
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AZI2__Homo_sapiens__NP_001127904

<400>  1002

Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys 
1               5                   10                  15      


Ala His Lys Arg Asp Thr Val Thr Pro Val Ser Ile Tyr Ser Gly Asp 
            20                  25                  30          


Glu Ser Val Ala Ser His Phe Ala Leu Val Thr Ala Tyr Glu Asp Ile 
        35                  40                  45              


Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys 
    50                  55                  60                  


Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu 
65                  70                  75                  80  


Thr Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala Tyr 
                85                  90                  95      


Arg Glu Val Cys Ile Asp Arg Asp Asn Leu Lys Ser Lys Leu Asp Lys 
            100                 105                 110         


Met Asn Lys Asp Asn Ser Glu Ser Leu Lys Val Leu Asn Glu Gln Leu 
        115                 120                 125             


Gln Ser Lys Glu Val Glu Leu Leu Gln Leu Arg Thr Glu Val Glu Thr 
    130                 135                 140                 


Gln Gln Val Met Arg Asn Leu Asn Pro Pro Ser Ser Asn Trp Glu Val 
145                 150                 155                 160 


Glu Lys Leu Ser Cys Asp Leu Lys Ile His Gly Leu Glu Gln Glu Leu 
                165                 170                 175     


Glu Leu Met Arg Lys Glu Cys Ser Asp Leu Lys Ile Glu Leu Gln Lys 
            180                 185                 190         


Ala Lys Gln Thr Asp Pro Tyr Gln Glu Asp Asn Leu Lys Ser Arg Asp 
        195                 200                 205             


Leu Gln Lys Leu Ser Ile Ser Arg Gln Ser Ile Cys Ser Thr Ala Trp 
    210                 215                 220                 


Ser Ala Val Ala Gln Ser Trp Asp Ser Met Asn Phe Glu Asp Cys Ser 
225                 230                 235                 240 


Leu Phe Ala 
            


<210>  1003
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AZIN1__Homo_sapiens__NP_001288597

<400>  1003

Met Lys Gly Phe Ile Asp Asp Ala Asn Tyr Ser Val Gly Leu Leu Asp 
1               5                   10                  15      


Glu Gly Thr Asn Leu Gly Asn Val Ile Asp Asn Tyr Val Tyr Glu His 
            20                  25                  30          


Thr Leu Thr Gly Lys Asn Ala Phe Phe Val Gly Asp Leu Gly Lys Ile 
        35                  40                  45              


Val Lys Lys His Ser Gln Trp Gln Asn Val Val Ala Gln Ile Lys Pro 
    50                  55                  60                  


Phe Tyr Thr Val Lys Cys Asn Ser Ala Pro Ala Val Leu Glu Ile Leu 
65                  70                  75                  80  


Ala Ala Leu Gly Thr Gly Phe Ala Cys Ser Ser Lys Asn Glu Met Ala 
                85                  90                  95      


Leu Val Gln Glu Leu Gly Val Pro Pro Glu Asn Ile Ile Tyr Ile Ser 
            100                 105                 110         


Pro Cys Lys Gln Val Ser Gln Ile Lys Tyr Ala Ala Lys Val Gly Val 
        115                 120                 125             


Asn Ile Leu Thr Cys Asp Asn Glu Ile Glu Leu Lys Lys Ile Ala Arg 
    130                 135                 140                 


Asn His Pro Asn Ala Lys Val Leu Leu His Ile Ala Thr Glu Asp Asn 
145                 150                 155                 160 


Ile Gly Gly Glu Glu Gly Asn Met Lys Phe Gly Thr Thr Leu Lys Asn 
                165                 170                 175     


Cys Arg His Leu Leu Glu Cys Ala Lys Glu Leu Asp Val Gln Ile Ile 
            180                 185                 190         


Gly Val Lys Phe His Val Ser Ser Ala Cys Lys Glu Ser Gln Val Tyr 
        195                 200                 205             


Val His Ala Leu Ser Asp Ala Arg Cys Val Phe Asp Met Ala Gly Glu 
    210                 215                 220                 


Ile Gly Phe Thr Met Asn Met Leu Asp Ile Gly Gly Gly Phe Thr Gly 
225                 230                 235                 240 


Thr Glu Phe Gln Leu Glu Glu Val Asn His Val Ile Ser Pro Leu Leu 
                245                 250                 255     


Asp Ile Tyr Phe Pro Glu Gly Ser Gly Val Lys Ile Ile Ser Glu Pro 
            260                 265                 270         


Gly Ser Tyr Tyr Val Ser Ser Ala Phe Thr Leu Ala Val Asn Ile Ile 
        275                 280                 285             


Ala Lys Lys Val Val Glu Asn Asp Lys Phe Pro Ser Gly Val Glu Lys 
    290                 295                 300                 


Thr Gly Ser Asp Glu Pro Ala Phe Met Tyr Tyr Met Asn Asp Gly Val 
305                 310                 315                 320 


Tyr Gly Ser Phe Ala Ser Lys Leu Ser Glu Asp Leu Asn Thr Ile Pro 
                325                 330                 335     


Glu Val His Lys Lys Tyr Lys Glu Asp Glu Pro Leu Phe Thr Ser Ser 
            340                 345                 350         


Leu Trp Gly Pro Ser Cys Asp Glu Leu Phe Arg 
        355                 360             


<210>  1004
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AZIN2__Homo_sapiens__NP_001288754

<400>  1004

Met Ala Gly Tyr Leu Ser Glu Ser Asp Phe Val Met Val Glu Glu Gly 
1               5                   10                  15      


Phe Ser Thr Arg Asp Leu Leu Lys Glu Leu Thr Leu Gly Ala Ser Gln 
            20                  25                  30          


Ala Thr Thr Asp Glu Val Ala Ala Phe Phe Val Ala Asp Leu Gly Ala 
        35                  40                  45              


Ile Val Arg Lys His Phe Cys Phe Leu Lys Cys Leu Pro Arg Val Arg 
    50                  55                  60                  


Pro Phe Tyr Ala Val Lys Cys Asn Ser Ser Pro Gly Val Leu Lys Val 
65                  70                  75                  80  


Leu Ala Gln Leu Gly Leu Gly Phe Ser Cys Ala Asn Lys Ala Glu Met 
                85                  90                  95      


Glu Leu Val Gln His Ile Gly Ile Pro Ala Ser Lys Ile Ile Cys Ala 
            100                 105                 110         


Asn Pro Cys Lys Gln Ile Ala Gln Ile Lys Tyr Ala Ala Lys His Gly 
        115                 120                 125             


Ile Gln Leu Leu Ser Phe Asp Asn Glu Met Glu Leu Ala Lys Val Val 
    130                 135                 140                 


Lys Ser His Pro Ser Ala Lys Met Val Leu Cys Ile Ala Thr Asp Asp 
145                 150                 155                 160 


Ser His Ser Leu Ser Cys Leu Ser Leu Lys Phe Gly Val Ser Leu Lys 
                165                 170                 175     


Ser Cys Arg His Leu Leu Glu Asn Ala Lys Lys His His Val Glu Val 
            180                 185                 190         


Val Gly Val Ser Phe His Ile Gly Ser Gly Cys Pro Asp Pro Gln Ala 
        195                 200                 205             


Tyr Ala Gln Ser Ile Ala Asp Ala Arg Leu Val Phe Glu Met Gly Thr 
    210                 215                 220                 


Glu Leu Gly His Lys Met His Val Leu Asp Leu Gly Gly Gly Phe Pro 
225                 230                 235                 240 


Gly Thr Glu Gly Ala Lys Val Arg Phe Glu Glu Ile Ala Ser Val Ile 
                245                 250                 255     


Asn Ser Ala Leu Asp Leu Tyr Phe Pro Glu Gly Cys Gly Val Asp Ile 
            260                 265                 270         


Phe Ala Glu Leu Gly Arg Tyr Tyr Val Thr Ser Ala Phe Thr Val Ala 
        275                 280                 285             


Val Ser Ile Ile Ala Lys Lys Glu Val Leu Leu Asp Gln Pro Gly Arg 
    290                 295                 300                 


Glu Ala Pro Leu Pro Pro Pro His Ile Ala Thr Cys Ala Ala Ser Glu 
305                 310                 315                 320 


Pro Ser Pro Pro Ala Glu Glu Asn Gly Ser Thr Ser Lys Thr Ile Val 
                325                 330                 335     


Tyr His Leu Asp Glu Gly Val Tyr Gly Ile Phe Asn Ser Val Leu Phe 
            340                 345                 350         


Asp Asn Ile Cys Pro Thr Pro Ile Leu Gln Lys Lys Pro Ser Thr Glu 
        355                 360                 365             


Gln Pro Leu Tyr Ser Ser Ser Leu Trp Gly Pro Ala Val Asp Gly Cys 
    370                 375                 380                 


Asp Cys Val Ala Glu Gly Leu Trp Leu Pro Gln Leu His Val Gly Asp 
385                 390                 395                 400 


Trp Leu Val Phe Asp Asn Met Gly Ala Tyr Thr Val Gly Met Gly Ser 
                405                 410                 415     


Pro Phe Trp Gly Thr Gln Ala Cys His Ile Thr Tyr Ala Met Ser Arg 
            420                 425                 430         


Val Ala Trp Glu Ala Leu Arg Arg Gln Leu Met Ala Ala Glu Gln Glu 
        435                 440                 445             


Asp Asp Val Glu Gly Val Cys Lys Pro Leu Ser Cys Gly Trp Glu Ile 
    450                 455                 460                 


Thr Asp Thr Leu Cys Val Gly Pro Val Phe Thr Pro Ala Ser Ile Met 
465                 470                 475                 480 


<210>  1005
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AZU1__Homo_sapiens__NP_001691

<400>  1005

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Gly Ser Ser Pro Leu Leu Asp Ile Val Gly Gly Arg Lys 
            20                  25                  30          


Ala Arg Pro Arg Gln Phe Pro Phe Leu Ala Ser Ile Gln Asn Gln Gly 
        35                  40                  45              


Arg His Phe Cys Gly Gly Ala Leu Ile His Ala Arg Phe Val Met Thr 
    50                  55                  60                  


Ala Ala Ser Cys Phe Gln Ser Gln Asn Pro Gly Val Ser Thr Val Val 
65                  70                  75                  80  


Leu Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg Gln Thr 
                85                  90                  95      


Phe Ser Ile Ser Ser Met Ser Glu Asn Gly Tyr Asp Pro Gln Gln Asn 
            100                 105                 110         


Leu Asn Asp Leu Met Leu Leu Gln Leu Asp Arg Glu Ala Asn Leu Thr 
        115                 120                 125             


Ser Ser Val Thr Ile Leu Pro Leu Pro Leu Gln Asn Ala Thr Val Glu 
    130                 135                 140                 


Ala Gly Thr Arg Cys Gln Val Ala Gly Trp Gly Ser Gln Arg Ser Gly 
145                 150                 155                 160 


Gly Arg Leu Ser Arg Phe Pro Arg Phe Val Asn Val Thr Val Thr Pro 
                165                 170                 175     


Glu Asp Gln Cys Arg Pro Asn Asn Val Cys Thr Gly Val Leu Thr Arg 
            180                 185                 190         


Arg Gly Gly Ile Cys Asn Gly Asp Gly Gly Thr Pro Leu Val Cys Glu 
        195                 200                 205             


Gly Leu Ala His Gly Val Ala Ser Phe Ser Leu Gly Pro Cys Gly Arg 
    210                 215                 220                 


Gly Pro Asp Phe Phe Thr Arg Val Ala Leu Phe Arg Asp Trp Ile Asp 
225                 230                 235                 240 


Gly Val Leu Asn Asn Pro Gly Pro Gly Pro Ala 
                245                 250     


<210>  1006
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2M__Homo_sapiens__NP_004039

<400>  1006

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  1007
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GALNT1__Homo_sapiens__XP_005247921

<400>  1007

Met Ala Ser Ala Leu Trp Thr Val Leu Pro Ser Arg Met Ser Leu Arg 
1               5                   10                  15      


Ser Leu Lys Trp Ser Leu Leu Leu Leu Ser Leu Leu Ser Phe Phe Val 
            20                  25                  30          


Met Trp Tyr Leu Ser Leu Pro His Tyr Asn Val Ile Glu Arg Val Asn 
        35                  40                  45              


Trp Met Tyr Phe Tyr Glu Tyr Glu Pro Ile Tyr Arg Gln Asp Phe His 
    50                  55                  60                  


Phe Thr Leu Arg Glu His Ser Asn Cys Ser His Gln Asn Pro Phe Leu 
65                  70                  75                  80  


Val Ile Leu Val Thr Ser His Pro Ser Asp Val Lys Ala Arg Gln Ala 
                85                  90                  95      


Ile Arg Val Thr Trp Gly Glu Lys Lys Ser Trp Trp Gly Tyr Glu Val 
            100                 105                 110         


Leu Thr Phe Phe Leu Leu Gly Gln Glu Ala Glu Lys Glu Asp Lys Met 
        115                 120                 125             


Leu Ala Leu Ser Leu Glu Asp Glu His Leu Leu Tyr Gly Asp Ile Ile 
    130                 135                 140                 


Arg Gln Asp Phe Leu Asp Thr Tyr Asn Asn Leu Thr Leu Lys Thr Ile 
145                 150                 155                 160 


Met Ala Phe Arg Trp Val Thr Glu Phe Cys Pro Asn Ala Lys Tyr Val 
                165                 170                 175     


Met Lys Thr Asp Thr Asp Val Phe Ile Asn Thr Gly Asn Leu Val Lys 
            180                 185                 190         


Tyr Leu Leu Asn Leu Asn His Ser Glu Lys Phe Phe Thr Gly Tyr Pro 
        195                 200                 205             


Leu Ile Asp Asn Tyr Ser Tyr Arg Gly Phe Tyr Gln Lys Thr His Ile 
    210                 215                 220                 


Ser Tyr Gln Glu Tyr Pro Phe Lys Val Phe Pro Pro Tyr Cys Ser Gly 
225                 230                 235                 240 


Leu Gly Tyr Ile Met Ser Arg Asp Leu Val Pro Arg Ile Tyr Glu Met 
                245                 250                 255     


Met Gly His Val Lys Pro Ile Lys Phe Glu Asp Val Tyr Val Gly Ile 
            260                 265                 270         


Cys Leu Asn Leu Leu Lys Val Asn Ile His Ile Pro Glu Asp Thr Asn 
        275                 280                 285             


Leu Phe Phe Leu Tyr Arg Ile His Leu Asp Val Cys Gln Leu Arg Arg 
    290                 295                 300                 


Val Ile Ala Ala His Gly Phe Ser Ser Lys Glu Ile Ile Thr Phe Trp 
305                 310                 315                 320 


Gln Val Met Leu Arg Asn Thr Thr Cys His Tyr 
                325                 330     


<210>  1008
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GALNT2__Homo_sapiens__NP_001264084

<400>  1008

Met Arg Asn Trp Leu Val Leu Leu Cys Pro Cys Val Leu Gly Ala Ala 
1               5                   10                  15      


Leu His Leu Trp Leu Arg Leu Arg Ser Pro Pro Pro Ala Cys Ala Ser 
            20                  25                  30          


Gly Ala Gly Pro Ala Gly Gly Val Ser Leu Leu Leu Pro Arg Leu Glu 
        35                  40                  45              


Cys Asn Gly Ala Val Ser Ala His Pro Asn Leu His Leu Pro Gly Ser 
    50                  55                  60                  


Arg Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile Thr Asp Gln 
65                  70                  75                  80  


Leu Ala Leu Phe Pro Gln Trp Lys Ser Thr His Tyr Asp Val Val Val 
                85                  90                  95      


Gly Val Leu Ser Ala Arg Asn Asn His Glu Leu Arg Asn Val Ile Arg 
            100                 105                 110         


Ser Thr Trp Met Arg His Leu Leu Gln His Pro Thr Leu Ser Gln Arg 
        115                 120                 125             


Val Leu Val Lys Phe Ile Ile Gly Ala His Gly Cys Glu Val Pro Val 
    130                 135                 140                 


Glu Asp Arg Glu Asp Pro Tyr Ser Cys Lys Leu Leu Asn Ile Thr Asn 
145                 150                 155                 160 


Pro Val Leu Asn Gln Glu Ile Glu Ala Phe Ser Leu Ser Glu Asp Thr 
                165                 170                 175     


Ser Ser Gly Leu Pro Glu Asp Arg Val Val Ser Val Ser Phe Arg Val 
            180                 185                 190         


Leu Tyr Pro Ile Val Ile Thr Ser Leu Gly Val Phe Tyr Asp Ala Asn 
        195                 200                 205             


Asp Val Gly Phe Gln Arg Asn Ile Thr Val Lys Leu Tyr Gln Ala Glu 
    210                 215                 220                 


Gln Glu Glu Ala Leu Phe Ile Ala Arg Phe Ser Pro Pro Ser Cys Gly 
225                 230                 235                 240 


Val Gln Val Asn Lys Leu Trp Tyr Lys Pro Val Glu Gln Phe Ile Leu 
                245                 250                 255     


Pro Glu Ser Phe Glu Gly Thr Ile Val Trp Glu Ser Gln Asp Leu His 
            260                 265                 270         


Gly Leu Val Ser Arg Asn Leu His Lys Val Thr Val Asn Asp Gly Gly 
        275                 280                 285             


Gly Val Leu Arg Val Ile Thr Ala Gly Glu Gly Ala Leu Pro His Glu 
    290                 295                 300                 


Phe Leu Glu Gly Val Glu Gly Val Ala Gly Gly Phe Ile Tyr Thr Ile 
305                 310                 315                 320 


Gln Gly Lys Phe Ala Ser 
                325     


<210>  1009
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GALT2__Homo_sapiens__NP_003774

<400>  1009

Met Leu Gln Trp Arg Arg Arg His Cys Cys Phe Ala Lys Met Thr Trp 
1               5                   10                  15      


Asn Ala Lys Arg Ser Leu Phe Arg Thr His Leu Ile Gly Val Leu Ser 
            20                  25                  30          


Leu Val Phe Leu Phe Ala Met Phe Leu Phe Phe Asn His His Asp Trp 
        35                  40                  45              


Leu Pro Gly Arg Ala Gly Phe Lys Glu Asn Pro Val Thr Tyr Thr Phe 
    50                  55                  60                  


Arg Gly Phe Arg Ser Thr Lys Ser Glu Thr Asn His Ser Ser Leu Arg 
65                  70                  75                  80  


Asn Ile Trp Lys Glu Thr Val Pro Gln Thr Leu Arg Pro Gln Thr Ala 
                85                  90                  95      


Thr Asn Ser Asn Asn Thr Asp Leu Ser Pro Gln Gly Val Thr Gly Leu 
            100                 105                 110         


Glu Asn Thr Leu Ser Ala Asn Gly Ser Ile Tyr Asn Glu Lys Gly Thr 
        115                 120                 125             


Gly His Pro Asn Ser Tyr His Phe Lys Tyr Ile Ile Asn Glu Pro Glu 
    130                 135                 140                 


Lys Cys Gln Glu Lys Ser Pro Phe Leu Ile Leu Leu Ile Ala Ala Glu 
145                 150                 155                 160 


Pro Gly Gln Ile Glu Ala Arg Arg Ala Ile Arg Gln Thr Trp Gly Asn 
                165                 170                 175     


Glu Ser Leu Ala Pro Gly Ile Gln Ile Thr Arg Ile Phe Leu Leu Gly 
            180                 185                 190         


Leu Ser Ile Lys Leu Asn Gly Tyr Leu Gln Arg Ala Ile Leu Glu Glu 
        195                 200                 205             


Ser Arg Gln Tyr His Asp Ile Ile Gln Gln Glu Tyr Leu Asp Thr Tyr 
    210                 215                 220                 


Tyr Asn Leu Thr Ile Lys Thr Leu Met Gly Met Asn Trp Val Ala Thr 
225                 230                 235                 240 


Tyr Cys Pro His Ile Pro Tyr Val Met Lys Thr Asp Ser Asp Met Phe 
                245                 250                 255     


Val Asn Thr Glu Tyr Leu Ile Asn Lys Leu Leu Lys Pro Asp Leu Pro 
            260                 265                 270         


Pro Arg His Asn Tyr Phe Thr Gly Tyr Leu Met Arg Gly Tyr Ala Pro 
        275                 280                 285             


Asn Arg Asn Lys Asp Ser Lys Trp Tyr Met Pro Pro Asp Leu Tyr Pro 
    290                 295                 300                 


Ser Glu Arg Tyr Pro Val Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser 
305                 310                 315                 320 


Gly Asp Leu Ala Glu Lys Ile Phe Lys Val Ser Leu Gly Ile Arg Arg 
                325                 330                 335     


Leu His Leu Glu Asp Val Tyr Val Gly Ile Cys Leu Ala Lys Leu Arg 
            340                 345                 350         


Ile Asp Pro Val Pro Pro Pro Asn Glu Phe Val Phe Asn His Trp Arg 
        355                 360                 365             


Val Ser Tyr Ser Ser Cys Lys Tyr Ser His Leu Ile Thr Ser His Gln 
    370                 375                 380                 


Phe Gln Pro Ser Glu Leu Ile Lys Tyr Trp Asn His Leu Gln Gln Asn 
385                 390                 395                 400 


Lys His Asn Ala Cys Ala Asn Ala Ala Lys Glu Lys Ala Gly Arg Tyr 
                405                 410                 415     


Arg His Arg Lys Leu His 
            420         


<210>  1010
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GALT4__Homo_sapiens__NP_003773

<400>  1010

Met Gln Leu Arg Leu Phe Arg Arg Leu Leu Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      


Val Ile Val Trp Thr Leu Phe Gly Pro Ser Gly Leu Gly Glu Glu Leu 
            20                  25                  30          


Leu Ser Leu Ser Leu Ala Ser Leu Leu Pro Ala Pro Ala Ser Pro Gly 
        35                  40                  45              


Pro Pro Leu Ala Leu Pro Arg Leu Leu Ile Pro Asn Gln Glu Ala Cys 
    50                  55                  60                  


Ser Gly Pro Gly Ala Pro Pro Phe Leu Leu Ile Leu Val Cys Thr Ala 
65                  70                  75                  80  


Pro Glu Asn Leu Asn Gln Arg Asn Ala Ile Arg Ala Ser Trp Gly Gly 
                85                  90                  95      


Leu Arg Glu Ala Arg Gly Leu Arg Val Gln Thr Leu Phe Leu Leu Gly 
            100                 105                 110         


Glu Pro Asn Ala Gln His Pro Val Trp Gly Ser Gln Gly Ser Asp Leu 
        115                 120                 125             


Ala Ser Glu Ser Ala Ala Gln Gly Asp Ile Leu Gln Ala Ala Phe Gln 
    130                 135                 140                 


Asp Ser Tyr Arg Asn Leu Thr Leu Lys Thr Leu Ser Gly Leu Asn Trp 
145                 150                 155                 160 


Ala Glu Lys His Cys Pro Met Ala Arg Tyr Val Leu Lys Thr Asp Asp 
                165                 170                 175     


Asp Val Tyr Val Asn Val Pro Glu Leu Val Ser Glu Leu Val Leu Arg 
            180                 185                 190         


Gly Gly Arg Trp Gly Gln Trp Glu Arg Ser Thr Glu Pro Gln Arg Glu 
        195                 200                 205             


Ala Glu Gln Glu Gly Gly Gln Val Leu His Ser Glu Glu Val Pro Leu 
    210                 215                 220                 


Leu Tyr Leu Gly Arg Val His Trp Arg Val Asn Pro Ser Arg Thr Pro 
225                 230                 235                 240 


Gly Gly Arg His Arg Val Ser Glu Glu Gln Trp Pro His Thr Trp Gly 
                245                 250                 255     


Pro Phe Pro Pro Tyr Ala Ser Gly Thr Gly Tyr Val Leu Ser Ala Ser 
            260                 265                 270         


Ala Val Gln Leu Ile Leu Lys Val Ala Ser Arg Ala Pro Leu Leu Pro 
        275                 280                 285             


Leu Glu Asp Val Phe Val Gly Val Ser Ala Arg Arg Gly Gly Leu Ala 
    290                 295                 300                 


Pro Thr Gln Cys Val Lys Leu Ala Gly Ala Thr His Tyr Pro Leu Asp 
305                 310                 315                 320 


Arg Cys Cys Tyr Gly Lys Phe Leu Leu Thr Ser His Arg Leu Asp Pro 
                325                 330                 335     


Trp Lys Met Gln Glu Ala Trp Lys Leu Val Gly Gly Ser Asp Gly Glu 
            340                 345                 350         


Arg Thr Ala Pro Phe Cys Ser Trp Phe Gln Gly Val Leu Gly Ile Leu 
        355                 360                 365             


Arg Cys Arg Ala Ile Ala Trp Leu Gln Ser 
    370                 375             


<210>  1011
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GALT5__Homo_sapiens__NP_149361

<400>  1011

Met Ala Phe Pro Lys Met Arg Leu Met Tyr Ile Cys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Leu Cys Leu Tyr Phe Ser Met Tyr Ser Leu Asn Pro Phe Lys 
            20                  25                  30          


Glu Gln Ser Phe Val Tyr Lys Lys Asp Gly Asn Phe Leu Lys Leu Pro 
        35                  40                  45              


Asp Thr Asp Cys Arg Gln Thr Pro Pro Phe Leu Val Leu Leu Val Thr 
    50                  55                  60                  


Ser Ser His Lys Gln Leu Ala Glu Arg Met Ala Ile Arg Gln Thr Trp 
65                  70                  75                  80  


Gly Lys Glu Arg Met Val Lys Gly Lys Gln Leu Lys Thr Phe Phe Leu 
                85                  90                  95      


Leu Gly Thr Thr Ser Ser Ala Ala Glu Thr Lys Glu Val Asp Gln Glu 
            100                 105                 110         


Ser Gln Arg His Gly Asp Ile Ile Gln Lys Asp Phe Leu Asp Val Tyr 
        115                 120                 125             


Tyr Asn Leu Thr Leu Lys Thr Met Met Gly Ile Glu Trp Val His Arg 
    130                 135                 140                 


Phe Cys Pro Gln Ala Ala Phe Val Met Lys Thr Asp Ser Asp Met Phe 
145                 150                 155                 160 


Ile Asn Val Asp Tyr Leu Thr Glu Leu Leu Leu Lys Lys Asn Arg Thr 
                165                 170                 175     


Thr Arg Phe Phe Thr Gly Phe Leu Lys Leu Asn Glu Phe Pro Ile Arg 
            180                 185                 190         


Gln Pro Phe Ser Lys Trp Phe Val Ser Lys Ser Glu Tyr Pro Trp Asp 
        195                 200                 205             


Arg Tyr Pro Pro Phe Cys Ser Gly Thr Gly Tyr Val Phe Ser Gly Asp 
    210                 215                 220                 


Val Ala Ser Gln Val Tyr Asn Val Ser Lys Ser Val Pro Tyr Ile Lys 
225                 230                 235                 240 


Leu Glu Asp Val Phe Val Gly Leu Cys Leu Glu Arg Leu Asn Ile Arg 
                245                 250                 255     


Leu Glu Glu Leu His Ser Gln Pro Thr Phe Phe Pro Gly Gly Leu Arg 
            260                 265                 270         


Phe Ser Val Cys Leu Phe Arg Arg Ile Val Ala Cys His Phe Ile Lys 
        275                 280                 285             


Pro Arg Thr Leu Leu Asp Tyr Trp Gln Ala Leu Glu Asn Ser Arg Gly 
    290                 295                 300                 


Glu Asp Cys Pro Pro Val 
305                 310 


<210>  1012
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GALTL__Homo_sapiens__NP_919299

<400>  1012

Met Arg Pro Pro Ala Cys Trp Trp Leu Leu Ala Pro Pro Ala Leu Leu 
1               5                   10                  15      


Ala Leu Leu Thr Cys Ser Leu Ala Phe Gly Leu Ala Ser Glu Asp Thr 
            20                  25                  30          


Lys Lys Glu Val Lys Gln Ser Gln Asp Leu Glu Lys Ser Gly Ile Ser 
        35                  40                  45              


Arg Lys Asn Asp Ile Asp Leu Lys Gly Ile Val Phe Val Ile Gln Ser 
    50                  55                  60                  


Gln Ser Asn Ser Phe His Ala Lys Arg Ala Glu Gln Leu Lys Lys Ser 
65                  70                  75                  80  


Ile Leu Lys Gln Ala Ala Asp Leu Thr Gln Glu Leu Pro Ser Val Leu 
                85                  90                  95      


Leu Leu His Gln Leu Ala Lys Gln Glu Gly Ala Trp Thr Ile Leu Pro 
            100                 105                 110         


Leu Leu Pro His Phe Ser Val Thr Tyr Ser Arg Asn Ser Ser Trp Ile 
        115                 120                 125             


Phe Phe Cys Glu Glu Glu Thr Arg Ile Gln Ile Pro Lys Leu Leu Glu 
    130                 135                 140                 


Thr Leu Arg Arg Tyr Asp Pro Ser Lys Glu Trp Phe Leu Gly Lys Ala 
145                 150                 155                 160 


Leu His Asp Glu Glu Ala Thr Ile Ile His His Tyr Ala Phe Ser Glu 
                165                 170                 175     


Asn Pro Thr Val Phe Lys Tyr Pro Asp Phe Ala Ala Gly Trp Ala Leu 
            180                 185                 190         


Ser Ile Pro Leu Val Asn Lys Leu Thr Lys Arg Leu Lys Ser Glu Ser 
        195                 200                 205             


Leu Lys Ser Asp Phe Thr Ile Asp Leu Lys His Glu Ile Ala Leu Tyr 
    210                 215                 220                 


Ile Trp Asp Lys Gly Gly Gly Pro Pro Leu Thr Pro Val Pro Glu Phe 
225                 230                 235                 240 


Cys Thr Asn Asp Val Asp Phe Tyr Cys Ala Thr Thr Phe His Ser Phe 
                245                 250                 255     


Leu Pro Leu Cys Arg Lys Pro Val Lys Lys Lys Asp Ile Phe Val Ala 
            260                 265                 270         


Val Lys Thr Cys Lys Lys Phe His Gly Asp Arg Ile Pro Ile Val Lys 
        275                 280                 285             


Gln Thr Trp Glu Ser Gln Ala Ser Leu Ile Glu Tyr Tyr Ser Asp Tyr 
    290                 295                 300                 


Thr Glu Asn Ser Ile Pro Thr Val Asp Leu Gly Ile Pro Asn Thr Asp 
305                 310                 315                 320 


Arg Gly His Cys Gly Lys Thr Phe Ala Ile Leu Glu Arg Phe Leu Asn 
                325                 330                 335     


Arg Ser Gln Asp Lys Thr Ala Trp Leu Val Ile Val Asp Asp Asp Thr 
            340                 345                 350         


Leu Ile Ser Ile Ser Arg Leu Gln His Leu Leu Ser Cys Tyr Asp Ser 
        355                 360                 365             


Gly Glu Pro Val Phe Leu Gly Glu Arg Tyr Gly Tyr Gly Leu Gly Thr 
    370                 375                 380                 


Gly Gly Tyr Ser Tyr Ile Thr Gly Gly Gly Gly Met Val Phe Ser Arg 
385                 390                 395                 400 


Glu Ala Val Arg Arg Leu Leu Ala Ser Lys Cys Arg Cys Tyr Ser Asn 
                405                 410                 415     


Asp Ala Pro Asp Asp Met Val Leu Gly Met Cys Phe Ser Gly Leu Gly 
            420                 425                 430         


Ile Pro Val Thr His Ser Pro Leu Phe His Gln Ala Arg Pro Val Asp 
        435                 440                 445             


Tyr Pro Lys Asp Tyr Leu Ser His Gln Val Pro Ile Ser Phe His Lys 
    450                 455                 460                 


His Trp Asn Ile Asp Pro Val Lys Val Tyr Phe Thr Trp Leu Ala Pro 
465                 470                 475                 480 


Ser Asp Glu Asp Lys Ala Arg Gln Glu Thr Gln Lys Gly Phe Arg Glu 
                485                 490                 495     


Glu Leu 
        


<210>  1013
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GAT1__Homo_sapiens__XP_011541055

<400>  1013

Met Gly Asn Glu Glu Pro Trp Val Gln Pro Ala Leu Glu Met Pro Lys 
1               5                   10                  15      


Arg Arg Asp Ile Leu Ala Ile Val Leu Ile Val Leu Pro Trp Thr Leu 
            20                  25                  30          


Leu Ile Thr Val Trp His Gln Ser Thr Leu Ala Pro Leu Leu Ala Val 
        35                  40                  45              


His Lys Asp Glu Gly Ser Asp Pro Arg Arg Glu Thr Pro Pro Gly Ala 
    50                  55                  60                  


Asp Pro Arg Glu Tyr Cys Thr Ser Asp Arg Asp Ile Val Glu Val Val 
65                  70                  75                  80  


Arg Thr Glu Tyr Val Tyr Thr Arg Pro Pro Pro Trp Ser Asp Thr Leu 
                85                  90                  95      


Pro Thr Ile His Val Val Thr Pro Thr Tyr Ser Arg Pro Val Gln Lys 
            100                 105                 110         


Ala Glu Leu Thr Arg Met Ala Asn Thr Leu Leu His Val Pro Asn Leu 
        115                 120                 125             


His Trp Leu Val Val Glu Asp Ala Pro Arg Arg Thr Pro Leu Thr Ala 
    130                 135                 140                 


Arg Leu Leu Arg Asp Thr Gly Leu Asn Tyr Thr His Leu His Val Glu 
145                 150                 155                 160 


Thr Pro Arg Asn Tyr Lys Leu Arg Gly Asp Ala Arg Asp Pro Arg Ile 
                165                 170                 175     


Pro Arg Gly Thr Met Gln Arg Asn Leu Ala Leu Arg Trp Leu Arg Glu 
            180                 185                 190         


Thr Phe Pro Arg Asn Ser Ser Gln Pro Gly Val Val Tyr Phe Ala Asp 
        195                 200                 205             


Asp Asp Asn Thr Tyr Ser Leu Glu Leu Phe Glu Glu Met Arg Ser Thr 
    210                 215                 220                 


Arg Arg Val Ser Val Trp Pro Val Ala Phe Val Gly Gly Leu Arg Tyr 
225                 230                 235                 240 


Glu Ala Pro Arg Val Asn Gly Ala Gly Lys Val Val Gly Trp Lys Thr 
                245                 250                 255     


Val Phe Asp Pro His Arg Pro Phe Ala Ile Asp Met Ala Gly Phe Ala 
            260                 265                 270         


Val Asn Leu Arg Leu Ile Leu Gln Arg Ser Gln Ala Tyr Phe Lys Leu 
        275                 280                 285             


Arg Gly Val Lys Gly Gly Tyr Gln Glu Ser Ser Leu Leu Arg Glu Leu 
    290                 295                 300                 


Val Thr Leu Asn Asp Leu Glu Pro Lys Ala Ala Asn Cys Thr Lys Ile 
305                 310                 315                 320 


Leu Val Trp His Thr Arg Thr Glu Lys Pro Val Leu Val Asn Glu Gly 
                325                 330                 335     


Lys Lys Gly Phe Thr Asp Pro Ser Val Glu Ile 
            340                 345         


<210>  1014
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GAT2__Homo_sapiens__NP_542780

<400>  1014

Met Lys Ser Ala Leu Phe Thr Arg Phe Phe Ile Leu Leu Pro Trp Ile 
1               5                   10                  15      


Leu Ile Val Ile Ile Met Leu Asp Val Asp Thr Arg Arg Pro Val Pro 
            20                  25                  30          


Pro Leu Thr Pro Arg Pro Tyr Phe Ser Pro Tyr Ala Val Gly Arg Gly 
        35                  40                  45              


Gly Ala Arg Leu Pro Leu Arg Arg Gly Gly Pro Ala His Gly Thr Gln 
    50                  55                  60                  


Lys Arg Asn Gln Ser Arg Pro Gln Pro Gln Pro Glu Pro Gln Leu Pro 
65                  70                  75                  80  


Thr Ile Tyr Ala Ile Thr Pro Thr Tyr Ser Arg Pro Val Gln Lys Ala 
                85                  90                  95      


Glu Leu Thr Arg Leu Ala Asn Thr Phe Arg Gln Val Ala Gln Leu His 
            100                 105                 110         


Trp Ile Leu Val Glu Asp Ala Ala Ala Arg Ser Glu Leu Val Ser Arg 
        115                 120                 125             


Phe Leu Ala Arg Ala Gly Leu Pro Ser Thr His Leu His Val Pro Thr 
    130                 135                 140                 


Pro Arg Arg Tyr Lys Arg Pro Gly Leu Pro Arg Ala Thr Glu Gln Arg 
145                 150                 155                 160 


Asn Ala Gly Leu Ala Trp Leu Arg Gln Arg His Gln His Gln Arg Ala 
                165                 170                 175     


Gln Pro Gly Val Leu Phe Phe Ala Asp Asp Asp Asn Thr Tyr Ser Leu 
            180                 185                 190         


Glu Leu Phe Gln Glu Met Arg Thr Thr Arg Lys Val Ser Val Trp Pro 
        195                 200                 205             


Val Gly Leu Val Gly Gly Arg Arg Tyr Glu Arg Pro Leu Val Glu Asn 
    210                 215                 220                 


Gly Lys Val Val Gly Trp Tyr Thr Gly Trp Arg Ala Asp Arg Pro Phe 
225                 230                 235                 240 


Ala Ile Asp Met Ala Gly Phe Ala Val Ser Leu Gln Val Ile Leu Ser 
                245                 250                 255     


Asn Pro Lys Ala Val Phe Lys Arg Arg Gly Ser Gln Pro Gly Met Gln 
            260                 265                 270         


Glu Ser Asp Phe Leu Lys Gln Ile Thr Thr Val Glu Glu Leu Glu Pro 
        275                 280                 285             


Lys Ala Asn Asn Cys Thr Lys Val Leu Val Trp His Thr Arg Thr Glu 
    290                 295                 300                 


Lys Val Asn Leu Ala Asn Glu Pro Lys Tyr His Leu Asp Thr Val Lys 
305                 310                 315                 320 


Ile Glu Val 
            


<210>  1015
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GAT3__Homo_sapiens__NP_001275652

<400>  1015

Met Lys Leu Lys Leu Lys Asn Val Phe Leu Ala Tyr Phe Leu Val Ser 
1               5                   10                  15      


Ile Ala Gly Leu Leu Tyr Ala Leu Val Gln Leu Gly Gln Pro Cys Asp 
            20                  25                  30          


Cys Leu Pro Pro Leu Arg Ala Ala Ala Glu Gln Leu Arg Gln Lys Asp 
        35                  40                  45              


Leu Arg Ile Ser Gln Leu Gln Ala Glu Leu Arg Arg Pro Pro Pro Ala 
    50                  55                  60                  


Pro Ala Gln Pro Pro Glu Pro Glu Ala Leu Pro Thr Ile Tyr Val Val 
65                  70                  75                  80  


Thr Pro Thr Tyr Ala Arg Leu Val Gln Lys Ala Glu Leu Val Arg Leu 
                85                  90                  95      


Ser Gln Thr Leu Ser Leu Val Pro Arg Leu His Trp Leu Leu Val Glu 
            100                 105                 110         


Asp Ala Glu Gly Pro Thr Pro Leu Val Ser Gly Leu Leu Ala Ala Ser 
        115                 120                 125             


Gly Leu Leu Phe Thr His Leu Val Val Leu Thr Pro Lys Ala Gln Arg 
    130                 135                 140                 


Leu Arg Glu Gly Glu Pro Gly Trp Val His Pro Arg Gly Val Glu Gln 
145                 150                 155                 160 


Arg Asn Lys Ala Leu Asp Trp Leu Arg Gly Arg Gly Gly Ala Val Gly 
                165                 170                 175     


Gly Glu Lys Asp Pro Pro Pro Pro Gly Thr Gln Gly Val Val Tyr Phe 
            180                 185                 190         


Ala Asp Asp Asp Asn Thr Tyr Ser Arg Glu Leu Phe Glu Glu Met Arg 
        195                 200                 205             


Trp Thr Arg Gly Val Ser Val Trp Pro Val Gly Leu Val Gly Gly Leu 
    210                 215                 220                 


Arg Phe Glu Gly Pro Gln Val Gln Asp Gly Arg Val Val Gly Phe His 
225                 230                 235                 240 


Thr Ala Trp Glu Pro Ser Arg Pro Phe Pro Val Asp Met Ala Gly Phe 
                245                 250                 255     


Ala Val Ala Leu Pro Leu Leu Leu Asp Lys Pro Asn Ala Gln Phe Asp 
            260                 265                 270         


Ser Thr Ala Pro Arg Gly His Leu Glu Ser Ser Leu Leu Ser His Leu 
        275                 280                 285             


Val Asp Pro Lys Asp Leu Glu Pro Arg Ala Ala Asn Cys Thr Arg Thr 
    290                 295                 300                 


Glu Ser Arg Cys Val Thr Gln Ala Gly Val Gln 
305                 310                 315 


<210>  1016
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GNT2__Homo_sapiens__NP_001306004

<400>  1016

Met Ser Val Gly Arg Arg Arg Ile Lys Leu Leu Gly Ile Leu Met Met 
1               5                   10                  15      


Ala Asn Val Phe Ile Tyr Phe Ile Met Glu Val Ser Lys Ser Ser Ser 
            20                  25                  30          


Gln Glu Lys Asn Gly Lys Gly Glu Val Ile Ile Pro Lys Glu Lys Phe 
        35                  40                  45              


Trp Lys Ile Ser Thr Pro Pro Glu Ala Tyr Trp Asn Arg Glu Gln Glu 
    50                  55                  60                  


Lys Leu Asn Arg Gln Tyr Asn Pro Ile Leu Ser Met Leu Thr Asn Gln 
65                  70                  75                  80  


Thr Gly Glu Ala Gly Arg Leu Ser Asn Ile Ser His Leu Asn Tyr Cys 
                85                  90                  95      


Glu Pro Asp Leu Arg Val Thr Ser Val Val Thr Gly Phe Asn Asn Leu 
            100                 105                 110         


Pro Asp Arg Phe Lys Asp Phe Leu Leu Tyr Leu Arg Cys Arg Asn Tyr 
        115                 120                 125             


Ser Leu Leu Ile Asp Gln Pro Asp Lys Cys Ala Lys Lys Pro Phe Leu 
    130                 135                 140                 


Leu Leu Ala Ile Lys Ser Leu Thr Pro His Phe Ala Arg Arg Gln Ala 
145                 150                 155                 160 


Ile Arg Glu Ser Trp Gly Gln Glu Ser Asn Ala Gly Asn Gln Thr Val 
                165                 170                 175     


Val Arg Val Phe Leu Leu Gly Gln Thr Pro Pro Glu Asp Asn His Pro 
            180                 185                 190         


Asp Leu Ser Asp Met Leu Lys Phe Glu Ser Glu Lys His Gln Asp Ile 
        195                 200                 205             


Leu Met Trp Asn Tyr Arg Asp Thr Phe Phe Asn Leu Ser Leu Lys Glu 
    210                 215                 220                 


Val Leu Phe Leu Arg Trp Val Ser Thr Ser Cys Pro Asp Thr Glu Phe 
225                 230                 235                 240 


Val Phe Lys Gly Asp Asp Asp Val Phe Val Asn Thr His His Ile Leu 
                245                 250                 255     


Asn Tyr Leu Asn Ser Leu Ser Lys Thr Lys Ala Lys Asp Leu Phe Ile 
            260                 265                 270         


Gly Asp Val Ile His Asn Ala Gly Pro His Arg Asp Lys Lys Leu Lys 
        275                 280                 285             


Tyr Tyr Ile Pro Glu Val Val Tyr Ser Gly Leu Tyr Pro Pro Tyr Ala 
    290                 295                 300                 


Gly Gly Gly Gly Phe Leu Tyr Ser Gly His Leu Ala Leu Arg Leu Tyr 
305                 310                 315                 320 


His Ile Thr Asp Gln Val His Leu Tyr Pro Ile Asp Asp Val Tyr Thr 
                325                 330                 335     


Gly Met Cys Leu Gln Lys Leu Gly Leu Val Pro Glu Lys His Lys Gly 
            340                 345                 350         


Phe Arg Thr Phe Asp Ile Glu Glu Lys Asn Lys Asn Asn Ile Cys Ser 
        355                 360                 365             


Tyr Val Asp Leu Met Leu Val His Ser Arg Lys Pro Gln Glu Met Ile 
    370                 375                 380                 


Asp Ile Trp Ser Gln Leu Gln Ser Ala His Leu Lys Cys 
385                 390                 395         


<210>  1017
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GNT3__Homo_sapiens__XP_011525929

<400>  1017

Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 
1               5                   10                  15      


Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 
            20                  25                  30          


Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 
        35                  40                  45              


Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 
    50                  55                  60                  


Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 
65                  70                  75                  80  


Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 
                85                  90                  95      


Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 
            100                 105                 110         


Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 
        115                 120                 125             


Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 
    130                 135                 140                 


Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 
145                 150                 155                 160 


Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 
                165                 170                 175     


Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 
            180                 185                 190         


Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 
        195                 200                 205             


Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 
    210                 215                 220                 


Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 
225                 230                 235                 240 


Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro Glu 
                245                 250                 255     


Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly Gly 
            260                 265                 270         


Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala His 
        275                 280                 285             


Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu 
    290                 295                 300                 


Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr Ser 
305                 310                 315                 320 


Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys Phe 
                325                 330                 335     


Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met Leu 
            340                 345                 350         


Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys Gly Asn Gln 
        355                 360                 365             


Thr Gln Ile Tyr 
    370         


<210>  1018
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GNT5__Homo_sapiens__XP_011511531

<400>  1018

Met Arg Met Leu Val Ser Gly Arg Arg Val Lys Lys Trp Gln Leu Ile 
1               5                   10                  15      


Ile Gln Leu Phe Ala Thr Cys Phe Leu Ala Ser Leu Met Phe Phe Trp 
            20                  25                  30          


Glu Pro Ile Asp Asn His Ile Val Ser His Met Lys Ser Tyr Ser Tyr 
        35                  40                  45              


Arg Tyr Leu Ile Asn Ser Tyr Asp Phe Val Asn Asp Thr Leu Ser Leu 
    50                  55                  60                  


Lys His Thr Ser Ala Gly Pro Arg Tyr Gln Tyr Leu Ile Asn His Lys 
65                  70                  75                  80  


Glu Lys Cys Gln Ala Gln Asp Val Leu Leu Leu Leu Phe Val Lys Thr 
                85                  90                  95      


Ala Pro Glu Asn Tyr Asp Arg Arg Ser Gly Ile Arg Arg Thr Trp Gly 
            100                 105                 110         


Asn Glu Asn Tyr Val Arg Ser Gln Leu Asn Ala Asn Ile Lys Thr Leu 
        115                 120                 125             


Phe Ala Leu Gly Thr Pro Asn Pro Leu Glu Gly Glu Glu Leu Gln Arg 
    130                 135                 140                 


Lys Leu Ala Trp Glu Asp Gln Arg Tyr Asn Asp Ile Ile Gln Gln Asp 
145                 150                 155                 160 


Phe Val Asp Ser Phe Tyr Asn Leu Thr Leu Lys Leu Leu Met Gln Phe 
                165                 170                 175     


Ser Trp Ala Asn Thr Tyr Cys Pro His Ala Lys Phe Leu Met Thr Ala 
            180                 185                 190         


Asp Asp Asp Ile Phe Ile His Met Pro Asn Leu Ile Glu Tyr Leu Gln 
        195                 200                 205             


Ser Leu Glu Gln Ile Gly Val Gln Asp Phe Trp Ile Gly Arg Val His 
    210                 215                 220                 


Arg Gly Ala Pro Pro Ile Arg Asp Lys Ser Ser Lys Tyr Tyr Val Ser 
225                 230                 235                 240 


Tyr Glu Met Tyr Gln Trp Pro Ala Tyr Pro Asp Tyr Thr Ala Gly Ala 
                245                 250                 255     


Ala Tyr Val Ile Ser Gly Asp Val Ala Ala Lys Val Tyr Glu Ala Ser 
            260                 265                 270         


Gln Thr Leu Asn Ser Ser Leu Tyr Ile Asp Asp Val Phe Met Gly Leu 
        275                 280                 285             


Cys Ala Asn Lys Ile Gly Ile Val Pro Gln Asp His Val Phe Phe Ser 
    290                 295                 300                 


Gly Glu Gly Lys Thr Pro Tyr His Pro Cys Ile Tyr Glu Lys Met Met 
305                 310                 315                 320 


Thr Ser His Gly His Leu Glu Asp Leu Gln Asp Leu Trp Lys Asn Ala 
                325                 330                 335     


Thr Asp Pro Lys Val Lys Thr Ile Ser Lys Gly Phe Phe Gly Gln Ile 
            340                 345                 350         


Tyr Cys Arg Leu Met Lys Ile Ile Leu Leu Cys Lys Ile Ser Tyr Val 
        355                 360                 365             


Asp Thr Tyr Pro Cys Arg Ala Ala Phe Ile 
    370                 375             


<210>  1019
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GNT6__Homo_sapiens__NP_619651

<400>  1019

Met Ala Phe Pro Cys Arg Arg Ser Leu Thr Ala Lys Thr Leu Ala Cys 
1               5                   10                  15      


Leu Leu Val Gly Val Ser Phe Leu Ala Leu Gln Gln Trp Phe Leu Gln 
            20                  25                  30          


Ala Pro Arg Ser Pro Arg Glu Glu Arg Ser Pro Gln Glu Glu Thr Pro 
        35                  40                  45              


Glu Gly Pro Thr Asp Ala Pro Ala Ala Asp Glu Pro Pro Ser Glu Leu 
    50                  55                  60                  


Val Pro Gly Pro Pro Cys Val Ala Asn Ala Ser Ala Asn Ala Thr Ala 
65                  70                  75                  80  


Asp Phe Glu Gln Leu Pro Ala Arg Ile Gln Asp Phe Leu Arg Tyr Arg 
                85                  90                  95      


His Cys Arg His Phe Pro Leu Leu Trp Asp Ala Pro Ala Lys Cys Ala 
            100                 105                 110         


Gly Gly Arg Gly Val Phe Leu Leu Leu Ala Val Lys Ser Ala Pro Glu 
        115                 120                 125             


His Tyr Glu Arg Arg Glu Leu Ile Arg Arg Thr Trp Gly Gln Glu Arg 
    130                 135                 140                 


Ser Tyr Gly Gly Arg Pro Val Arg Arg Leu Phe Leu Leu Gly Thr Pro 
145                 150                 155                 160 


Gly Pro Glu Asp Glu Ala Arg Ala Glu Arg Leu Ala Glu Leu Val Ala 
                165                 170                 175     


Leu Glu Ala Arg Glu His Gly Asp Val Leu Gln Trp Ala Phe Ala Asp 
            180                 185                 190         


Thr Phe Leu Asn Leu Thr Leu Lys His Leu His Leu Leu Asp Trp Leu 
        195                 200                 205             


Ala Ala Arg Cys Pro His Ala Arg Phe Leu Leu Ser Gly Asp Asp Asp 
    210                 215                 220                 


Val Phe Val His Thr Ala Asn Val Val Arg Phe Leu Gln Ala Gln Pro 
225                 230                 235                 240 


Pro Gly Arg His Leu Phe Ser Gly Gln Leu Met Glu Gly Ser Val Pro 
                245                 250                 255     


Ile Arg Asp Ser Trp Ser Lys Tyr Phe Val Pro Pro Gln Leu Phe Pro 
            260                 265                 270         


Gly Ser Ala Tyr Pro Val Tyr Cys Ser Gly Gly Gly Phe Leu Leu Ser 
        275                 280                 285             


Gly Pro Thr Ala Arg Ala Leu Arg Ala Ala Ala Arg His Thr Pro Leu 
    290                 295                 300                 


Phe Pro Ile Asp Asp Ala Tyr Met Gly Met Cys Leu Glu Arg Ala Gly 
305                 310                 315                 320 


Leu Ala Pro Ser Gly His Glu Gly Ile Arg Pro Phe Gly Val Gln Leu 
                325                 330                 335     


Pro Gly Ala Gln Gln Ser Ser Phe Asp Pro Cys Met Tyr Arg Glu Leu 
            340                 345                 350         


Leu Leu Val His Arg Phe Ala Pro Tyr Glu Met Leu Leu Met Trp Lys 
        355                 360                 365             


Ala Leu His Ser Pro Ala Leu Ser Cys Asp Arg Gly His Arg Val Ser 
    370                 375                 380                 


<210>  1020
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GNT8__Homo_sapiens__NP_940942

<400>  1020

Met Arg Cys Pro Lys Cys Leu Leu Cys Leu Ser Ala Leu Leu Thr Leu 
1               5                   10                  15      


Leu Gly Leu Lys Val Tyr Ile Glu Trp Thr Ser Glu Ser Arg Leu Ser 
            20                  25                  30          


Lys Ala Tyr Pro Ser Pro Arg Gly Thr Pro Pro Ser Pro Thr Pro Ala 
        35                  40                  45              


Asn Pro Glu Pro Thr Leu Pro Ala Asn Leu Ser Thr Arg Leu Gly Gln 
    50                  55                  60                  


Thr Ile Pro Leu Pro Phe Ala Tyr Trp Asn Gln Gln Gln Trp Arg Leu 
65                  70                  75                  80  


Gly Ser Leu Pro Ser Gly Asp Ser Thr Glu Thr Gly Gly Cys Gln Ala 
                85                  90                  95      


Trp Gly Ala Ala Ala Ala Thr Glu Ile Pro Asp Phe Ala Ser Tyr Pro 
            100                 105                 110         


Lys Asp Leu Arg Arg Phe Leu Leu Ser Ala Ala Cys Arg Ser Phe Pro 
        115                 120                 125             


Gln Trp Leu Pro Gly Gly Gly Gly Ser Gln Val Ser Ser Cys Ser Asp 
    130                 135                 140                 


Thr Asp Val Pro Tyr Leu Leu Leu Ala Val Lys Ser Glu Pro Gly Arg 
145                 150                 155                 160 


Phe Ala Glu Arg Gln Ala Val Arg Glu Thr Trp Gly Ser Pro Ala Pro 
                165                 170                 175     


Gly Ile Arg Leu Leu Phe Leu Leu Gly Ser Pro Val Gly Glu Ala Gly 
            180                 185                 190         


Pro Asp Leu Asp Ser Leu Val Ala Trp Glu Ser Arg Arg Tyr Ser Asp 
        195                 200                 205             


Leu Leu Leu Trp Asp Phe Leu Asp Val Pro Phe Asn Gln Thr Leu Lys 
    210                 215                 220                 


Asp Leu Leu Leu Leu Ala Trp Leu Gly Arg His Cys Pro Thr Val Ser 
225                 230                 235                 240 


Phe Val Leu Arg Ala Gln Asp Asp Ala Phe Val His Thr Pro Ala Leu 
                245                 250                 255     


Leu Ala His Leu Arg Ala Leu Pro Pro Ala Ser Ala Arg Ser Leu Tyr 
            260                 265                 270         


Leu Gly Glu Val Phe Thr Gln Ala Met Pro Leu Arg Lys Pro Gly Gly 
        275                 280                 285             


Pro Phe Tyr Val Pro Glu Ser Phe Phe Glu Gly Gly Tyr Pro Ala Tyr 
    290                 295                 300                 


Ala Ser Gly Gly Gly Tyr Val Ile Ala Gly Arg Leu Ala Pro Trp Leu 
305                 310                 315                 320 


Leu Arg Ala Ala Ala Arg Val Ala Pro Phe Pro Phe Glu Asp Val Tyr 
                325                 330                 335     


Thr Gly Leu Cys Ile Arg Ala Leu Gly Leu Val Pro Gln Ala His Pro 
            340                 345                 350         


Gly Phe Leu Thr Ala Trp Pro Ala Asp Arg Thr Ala Asp His Cys Ala 
        355                 360                 365             


Phe Arg Asn Leu Leu Leu Val Arg Pro Leu Gly Pro Gln Ala Ser Ile 
    370                 375                 380                 


Arg Leu Trp Lys Gln Leu Gln Asp Pro Arg Leu Gln Cys 
385                 390                 395         


<210>  1021
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3GNTL1__Homo_sapiens__XP_006722335

<400>  1021

Met Ser Gly Ala Gly Val Gly Gly Ala Ser Glu Glu Ser Gln Ala Met 
1               5                   10                  15      


Gln Ala His Val Ser Ile Ile Leu Pro Val His Asn Ala Glu Pro Trp 
            20                  25                  30          


Leu Asp Glu Cys Leu Arg Ser Val Leu Gln Gln Asp Phe Glu Gly Thr 
        35                  40                  45              


Met Glu Leu Ser Val Phe Asn Asp Ala Ser Lys Asp Lys Ser Gly Ala 
    50                  55                  60                  


Ile Ile Glu Lys Trp Arg Val Lys Leu Glu Asp Ser Gly Val His Val 
65                  70                  75                  80  


Ile Ile Gly Gly His Asp Ser Pro Ser Pro Arg Gly Val Gly Tyr Ala 
                85                  90                  95      


Lys Asn Gln Ala Val Ala Gln Ser Ser Gly Ser Tyr Leu Cys Phe Leu 
            100                 105                 110         


Asp Ser Asp Asp Val Met Met Pro Gln Arg Val Arg Leu Gln His Glu 
        115                 120                 125             


Ala Ala Val Gln His Pro Ser Ser Ile Ile Gly Cys Arg Val Arg Arg 
    130                 135                 140                 


Asp Pro Pro Asn Ser Thr Glu Arg Tyr Thr Arg Trp Ile Asn Gln Leu 
145                 150                 155                 160 


Thr Pro Glu Gln Leu Leu Thr Gln Val Phe Thr Ser Asn Gly Pro Thr 
                165                 170                 175     


Val Ile Met Pro Thr Trp Phe Cys Ser Arg Ala Trp Phe Ser His Val 
            180                 185                 190         


Gly Pro Phe Asn Glu Gly Gly Gln Gly Val Pro Glu Asp Leu Leu Phe 
        195                 200                 205             


Phe Tyr Glu His Leu Arg Lys Gly Gly Gly Val Ile Arg Val Asp Gln 
    210                 215                 220                 


Ser Leu Leu Leu Tyr Arg His His Pro Gln Ala Ala Thr His Cys Val 
225                 230                 235                 240 


Leu Glu Thr Thr Ile Trp Thr His Arg Val Arg Phe Leu Glu Glu Gln 
                245                 250                 255     


Ala Leu Pro Arg Trp Ala Ala Phe Thr Ile Trp Asn Ala Gly Lys Gln 
            260                 265                 270         


Gly Arg Arg Leu Tyr Arg Ser Leu Thr Ala Gly Ser Gln Arg Lys Val 
        275                 280                 285             


Val Ala Phe Cys Asp Val Asp Glu Asn Lys Ile Arg Lys Gly Phe Tyr 
    290                 295                 300                 


Cys His Glu Asp Ser Gln Glu Arg Pro Lys Pro Arg Ile Pro Ile Leu 
305                 310                 315                 320 


His Phe Arg Ala Ala Arg Pro Pro Phe Val Ile Cys Val Lys Leu Asp 
                325                 330                 335     


Leu Thr Gly Gly Ala Phe Glu Asp Asn Leu Arg Ser Leu His Leu Gln 
            340                 345                 350         


Glu Gly Gln Asp Phe Leu His Phe Ser 
        355                 360     


<210>  1022
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALNT1__Homo_sapiens__NP_001263398

<400>  1022

Met Trp Leu Gly Arg Arg Ala Leu Cys Ala Leu Val Leu Leu Leu Ala 
1               5                   10                  15      


Cys Ala Ser Leu Gly Leu Leu Tyr Ala Ser Thr Arg Asp Ala Pro Gly 
            20                  25                  30          


Leu Arg Leu Pro Leu Ala Pro Trp Ala Pro Pro Gln Ser Pro Arg Arg 
        35                  40                  45              


Pro Glu Leu Pro Asp Leu Ala Pro Glu Pro Arg Tyr Ala His Ile Pro 
    50                  55                  60                  


Val Arg Ile Lys Glu Gln Val Val Gly Leu Leu Ala Trp Asn Asn Cys 
65                  70                  75                  80  


Ser Cys Glu Ser Ser Gly Gly Gly Leu Pro Leu Pro Phe Gln Lys Gln 
                85                  90                  95      


Val Arg Ala Ile Asp Leu Thr Lys Ala Phe Asp Pro Ala Glu Leu Arg 
            100                 105                 110         


Ala Ala Ser Ala Thr Arg Glu Gln Glu Phe Gln Ala Phe Leu Ser Arg 
        115                 120                 125             


Ser Gln Ser Pro Ala Asp Gln Leu Leu Ile Ala Pro Ala Asn Ser Pro 
    130                 135                 140                 


Leu Gln Tyr Pro Leu Gln Gly Val Glu Val Gln Pro Leu Arg Ser Ile 
145                 150                 155                 160 


Leu Val Pro Gly Leu Ser Leu Gln Ala Ala Ser Gly Gln Glu Val Tyr 
                165                 170                 175     


Gln Val Asn Leu Thr Ala Ser Leu Gly Thr Trp Asp Val Ala Gly Glu 
            180                 185                 190         


Val Thr Gly Val Thr Leu Thr Gly Glu Gly Gln Ala Asp Leu Thr Leu 
        195                 200                 205             


Val Ser Pro Gly Leu Asp Gln Leu Asn Arg Gln Leu Gln Leu Val Thr 
    210                 215                 220                 


Tyr Ser Ser Arg Ser Tyr Gln Thr Asn Thr Ala Asp Thr Gly Ala Arg 
225                 230                 235                 240 


Pro Gly Trp Arg Asp Gly Gln Ala Gly Gln Thr Glu Lys Asn Gln Lys 
                245                 250                 255     


Gly Trp Ser Gly Gln Met Ala Glu Gly Met Gly Gly Ile Trp Ala Met 
            260                 265                 270         


Ala Arg Ala Val Gln Pro His Asn Gly Cys Phe Asn Trp Thr Ser Arg 
        275                 280                 285             


Ala Arg Gly Arg Lys Gly Ala Phe Val His Leu Gly Leu Glu Gln Ala 
    290                 295                 300                 


Arg Gly Lys Pro Glu Pro Trp Val Cys Leu Pro Phe Arg Pro Thr Val 
305                 310                 315                 320 


Gly Gly Pro Arg Lys Arg Leu Val 
                325             


<210>  1023
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALNT2__Homo_sapiens__NP_001152859

<400>  1023

Met Thr Ser Gly Gly Ser Arg Phe Leu Trp Leu Leu Lys Ile Leu Val 
1               5                   10                  15      


Ile Ile Leu Val Leu Gly Ile Val Gly Phe Met Phe Gly Ser Met Phe 
            20                  25                  30          


Leu Gln Ala Val Phe Ser Ser Pro Lys Pro Glu Leu Pro Ser Pro Ala 
        35                  40                  45              


Pro Gly Val Gln Lys Leu Lys Leu Leu Pro Glu Glu Arg Leu Arg Asn 
    50                  55                  60                  


Leu Phe Ser Tyr Asp Gly Ile Trp Leu Phe Pro Lys Asn Gln Cys Lys 
65                  70                  75                  80  


Cys Glu Ala Asn Lys Glu Gln Gly Gly Tyr Asn Phe Gln Asp Ala Tyr 
                85                  90                  95      


Gly Gln Ser Asp Leu Pro Ala Val Lys Ala Arg Arg Gln Ala Glu Phe 
            100                 105                 110         


Glu His Phe Gln Arg Arg Glu Gly Leu Pro Arg Pro Leu Pro Leu Leu 
        115                 120                 125             


Val Gln Pro Asn Leu Pro Phe Gly Tyr Pro Val His Gly Val Glu Val 
    130                 135                 140                 


Met Pro Leu His Thr Val Pro Ile Pro Gly Leu Gln Phe Glu Gly Pro 
145                 150                 155                 160 


Asp Ala Pro Val Tyr Glu Val Thr Leu Thr Ala Ser Leu Gly Thr Leu 
                165                 170                 175     


Asn Thr Leu Ala Asp Val Pro Asp Ser Val Val Gln Gly Arg Gly Gln 
            180                 185                 190         


Lys Gln Leu Ile Ile Ser Thr Ser Asp Arg Lys Leu Leu Lys Phe Ile 
        195                 200                 205             


Leu Gln His Val Thr Tyr Thr Ser Thr Gly Tyr Gln His Gln Lys Val 
    210                 215                 220                 


Asp Ile Val Ser Leu Glu Ser Arg Ser Ser Val Ala Lys Phe Pro Val 
225                 230                 235                 240 


Thr Ile Arg His Pro Val Ile Pro Lys Leu Tyr Asp Pro Gly Pro Glu 
                245                 250                 255     


Arg Lys Leu Arg Asn Leu Val Thr Ile Ala Thr Lys Thr Phe Leu Arg 
            260                 265                 270         


Pro His Lys Leu Met Ile Met Leu Arg Ser Ile Arg Glu Tyr Tyr Pro 
        275                 280                 285             


Asp Leu Thr Val Ile Val Ala Asp Asp Ser Gln Lys Pro Leu Glu Ile 
    290                 295                 300                 


Lys Asp Asn His Val Glu Tyr Tyr Thr Met Pro Phe Gly Lys Gly Trp 
305                 310                 315                 320 


Phe Ala Gly Arg Asn Leu Ala Ile Ser Gln Val Thr Thr Lys Tyr Val 
                325                 330                 335     


Leu Trp Val Asp Asp Asp Phe Leu Phe Asn Glu Glu Thr Lys Ile Glu 
            340                 345                 350         


Val Leu Val Asp Val Leu Glu Lys Thr Glu Leu Asp Val Val Gly Gly 
        355                 360                 365             


Ser Val Leu Gly Asn Val Phe Gln Phe Lys Leu Leu Leu Glu Gln Ser 
    370                 375                 380                 


Glu Asn Gly Ala Cys Leu His Lys Arg Met Gly Phe Phe Gln Pro Leu 
385                 390                 395                 400 


Asp Gly Phe Pro Ser Cys Val Val Thr Ser Gly Val Val Asn Phe Phe 
                405                 410                 415     


Leu Ala His Thr Glu Arg Leu Gln Arg Val Gly Phe Asp Pro Arg Leu 
            420                 425                 430         


Gln Arg Val Ala His Ser Glu Phe Phe Ile Asp Gly Leu Gly Thr Leu 
        435                 440                 445             


Leu Val Gly Ser Cys Pro Glu Val Ile Ile Gly His Gln Ser Arg Ser 
    450                 455                 460                 


Pro Val Val Asp Ser Glu Leu Ala Ala Leu Glu Lys Thr Tyr Asn Thr 
465                 470                 475                 480 


Tyr Arg Ser Asn Thr Leu Thr Arg Val Gln Phe Lys Leu Ala Leu His 
                485                 490                 495     


Tyr Phe Lys Asn His Leu Gln Cys Ala Ala 
            500                 505     


<210>  1024
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALNT3__Homo_sapiens__NP_775864

<400>  1024

Met Gly Ser Pro Arg Ala Ala Arg Pro Pro Leu Leu Leu Arg Pro Val 
1               5                   10                  15      


Lys Leu Leu Arg Arg Arg Phe Arg Leu Leu Leu Ala Leu Ala Val Val 
            20                  25                  30          


Ser Val Gly Leu Trp Thr Leu Tyr Leu Glu Leu Val Ala Ser Ala Gln 
        35                  40                  45              


Val Gly Gly Asn Pro Leu Asn Arg Arg Tyr Gly Ser Trp Arg Glu Leu 
    50                  55                  60                  


Ala Lys Ala Leu Ala Ser Arg Asn Ile Pro Ala Val Asp Pro His Leu 
65                  70                  75                  80  


Gln Phe Tyr His Pro Gln Arg Leu Ser Leu Glu Asp His Asp Ile Asp 
                85                  90                  95      


Gln Gly Val Ser Ser Asn Ser Ser Tyr Leu Lys Trp Asn Lys Pro Val 
            100                 105                 110         


Pro Trp Leu Ser Glu Phe Arg Gly Arg Ala Asn Leu His Val Phe Glu 
        115                 120                 125             


Asp Trp Cys Gly Ser Ser Ile Gln Gln Leu Arg Arg Asn Leu His Phe 
    130                 135                 140                 


Pro Leu Tyr Pro His Ile Arg Thr Thr Leu Arg Lys Leu Ala Val Ser 
145                 150                 155                 160 


Pro Lys Trp Thr Asn Tyr Gly Leu Arg Ile Phe Gly Tyr Leu His Pro 
                165                 170                 175     


Phe Thr Asp Gly Lys Ile Gln Phe Ala Ile Ala Ala Asp Asp Asn Ala 
            180                 185                 190         


Glu Phe Trp Leu Ser Leu Asp Asp Gln Val Ser Gly Leu Gln Leu Leu 
        195                 200                 205             


Ala Ser Val Gly Lys Thr Gly Lys Glu Trp Thr Ala Pro Gly Glu Phe 
    210                 215                 220                 


Gly Lys Phe Arg Ser Gln Ile Ser Lys Pro Val Ser Leu Ser Ala Ser 
225                 230                 235                 240 


His Arg Tyr Tyr Phe Glu Val Leu His Lys Gln Asn Glu Glu Gly Thr 
                245                 250                 255     


Asp His Val Glu Val Ala Trp Arg Arg Asn Asp Pro Gly Ala Lys Phe 
            260                 265                 270         


Thr Ile Ile Asp Ser Leu Ser Leu Ser Leu Phe Thr Asn Glu Thr Phe 
        275                 280                 285             


Leu Gln Met Asp Glu Val Gly His Ile Pro Gln Thr Ala Ala Ser His 
    290                 295                 300                 


Val Asp Ser Ser Asn Ala Leu Pro Arg Asp Glu Gln Pro Pro Ala Asp 
305                 310                 315                 320 


Met Leu Arg Pro Asp Pro Arg Asp Thr Leu Tyr Arg Val Pro Leu Ile 
                325                 330                 335     


Pro Lys Ser His Leu Arg His Val Leu Pro Asp Cys Pro Tyr Lys Pro 
            340                 345                 350         


Ser Tyr Leu Val Asp Gly Leu Pro Leu Gln Arg Tyr Gln Gly Leu Arg 
        355                 360                 365             


Phe Val His Leu Ser Phe Val Tyr Pro Asn Asp Tyr Thr Arg Leu Ser 
    370                 375                 380                 


His Met Glu Thr His Asn Lys Cys Phe Tyr Gln Glu Asn Ala Tyr Tyr 
385                 390                 395                 400 


Gln Asp Arg Phe Ser Phe Gln Glu Tyr Ile Lys Ile Asp Gln Pro Glu 
                405                 410                 415     


Lys Gln Gly Leu Glu Gln Pro Gly Phe Glu Glu Asn Leu Leu Glu Glu 
            420                 425                 430         


Ser Gln Tyr Gly Glu Val Ala Glu Glu Thr Pro Ala Ser Asn Asn Gln 
        435                 440                 445             


Asn Ala Arg Met Leu Glu Gly Arg Gln Thr Pro Ala Ser Thr Leu Glu 
    450                 455                 460                 


Gln Asp Ala Thr Asp Tyr Arg Leu Arg Ser Leu Arg Lys Leu Leu Ala 
465                 470                 475                 480 


Gln Pro Arg Glu Gly Leu Leu Ala Pro Phe Ser Lys Arg Asn Ser Thr 
                485                 490                 495     


Ala Ser Phe Pro Gly Arg Thr Ser His Ile Pro Val Gln Gln Pro Glu 
            500                 505                 510         


Lys Arg Lys Gln Lys Pro Ser Pro Glu Pro Ser Gln Asp Ser Pro His 
        515                 520                 525             


Ser Asp Lys Trp Pro Pro Gly His Pro Val Lys Asn Leu Pro Gln Met 
    530                 535                 540                 


Arg Gly Pro Arg Pro Arg Pro Ala Gly Asp Ser Pro Arg Lys Thr Gln 
545                 550                 555                 560 


Trp Leu Asn Gln Val Glu Ser Tyr Ile Ala Glu Gln Arg Arg Gly Asp 
                565                 570                 575     


Arg Met Arg Pro Gln Ala Pro Gly Arg Gly Trp His Gly Glu Glu Glu 
            580                 585                 590         


Val Val Ala Ala Ala Gly Gln Glu Gly Gln Val Glu Gly Glu Glu Glu 
        595                 600                 605             


Gly Glu Glu Glu Glu Glu Glu Glu Asp Met Ser Glu Val Phe Glu Tyr 
    610                 615                 620                 


Val Pro Val Phe Asp Pro Val Val Asn Trp Asp Gln Thr Phe Ser Ala 
625                 630                 635                 640 


Arg Asn Leu Asp Phe Gln Ala Leu Arg Thr Asp Trp Ile Asp Leu Ser 
                645                 650                 655     


Cys Asn Thr Ser Gly Asn Leu Leu Leu Pro Glu Gln Glu Ala Leu Glu 
            660                 665                 670         


Val Thr Arg Val Phe Leu Lys Lys Leu Asn Gln Arg Ser Arg Gly Arg 
        675                 680                 685             


Tyr Gln Leu Gln Arg Ile Val Asn Val Glu Lys Arg Gln Asp Gln Leu 
    690                 695                 700                 


Arg Gly Gly Arg Tyr Leu Leu Glu Leu Glu Leu Leu Glu Gln Gly Gln 
705                 710                 715                 720 


Arg Val Val Arg Leu Ser Glu Tyr Val Ser Ala Arg Gly Trp Gln Gly 
                725                 730                 735     


Ile Asp Pro Ala Gly Gly Glu Glu Val Glu Ala Arg Asn Leu Gln Gly 
            740                 745                 750         


Leu Val Trp Asp Pro His Asn Arg Arg Arg Gln Val Leu Asn Thr Arg 
        755                 760                 765             


Ala Gln Glu Pro Lys Leu Cys Trp Pro Gln Gly Phe Ser Trp Ser His 
    770                 775                 780                 


Arg Ala Val Val His Phe Val Val Pro Val Lys Asn Gln Ala Arg Trp 
785                 790                 795                 800 


Val Gln Gln Phe Ile Lys Asp Met Glu Asn Leu Phe Gln Val Thr Gly 
                805                 810                 815     


Asp Pro His Phe Asn Ile Val Ile Thr Asp Tyr Ser Ser Glu Asp Met 
            820                 825                 830         


Asp Val Glu Met Ala Leu Lys Arg Ser Lys Leu Arg Ser Tyr Gln Tyr 
        835                 840                 845             


Val Lys Leu Ser Gly Asn Phe Glu Arg Ser Ala Gly Leu Gln Ala Gly 
    850                 855                 860                 


Ile Asp Leu Val Lys Asp Pro His Ser Ile Ile Phe Leu Cys Asp Leu 
865                 870                 875                 880 


His Ile His Phe Pro Ala Gly Val Ile Asp Ala Ile Arg Lys His Cys 
                885                 890                 895     


Val Glu Gly Lys Met Ala Phe Ala Pro Met Val Met Arg Leu His Cys 
            900                 905                 910         


Gly Ala Thr Pro Gln Trp Pro Glu Gly Tyr Trp Glu Val Asn Gly Phe 
        915                 920                 925             


Gly Leu Leu Gly Ile Tyr Lys Ser Asp Leu Asp Arg Ile Gly Gly Met 
    930                 935                 940                 


Asn Thr Lys Glu Phe Arg Asp Arg Trp Gly Gly Glu Asp Trp Glu Leu 
945                 950                 955                 960 


Leu Asp Arg Ile Leu Gln Ala Gly Leu Asp Val Glu Arg Leu Ser Leu 
                965                 970                 975     


Arg Asn Phe Phe His His Phe His Ser Lys Arg Gly Met Trp Ser Arg 
            980                 985                 990         


Arg Gln Met Lys Thr Leu 
        995             


<210>  1025
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALT1__Homo_sapiens__NP_001488

<400>  1025

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210>  1026
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALT3__Homo_sapiens__NP_003770

<400>  1026

Met Leu Arg Arg Leu Leu Glu Arg Pro Cys Thr Leu Ala Leu Leu Val 
1               5                   10                  15      


Gly Ser Gln Leu Ala Val Met Met Tyr Leu Ser Leu Gly Gly Phe Arg 
            20                  25                  30          


Ser Leu Ser Ala Leu Phe Gly Arg Asp Gln Gly Pro Thr Phe Asp Tyr 
        35                  40                  45              


Ser His Pro Arg Asp Val Tyr Ser Asn Leu Ser His Leu Pro Gly Ala 
    50                  55                  60                  


Pro Gly Gly Pro Pro Ala Pro Gln Gly Leu Pro Tyr Cys Pro Glu Arg 
65                  70                  75                  80  


Ser Pro Leu Leu Val Gly Pro Val Ser Val Ser Phe Ser Pro Val Pro 
                85                  90                  95      


Ser Leu Ala Glu Ile Val Glu Arg Asn Pro Arg Val Glu Pro Gly Gly 
            100                 105                 110         


Arg Tyr Arg Pro Ala Gly Cys Glu Pro Arg Ser Arg Thr Ala Ile Ile 
        115                 120                 125             


Val Pro His Arg Ala Arg Glu His His Leu Arg Leu Leu Leu Tyr His 
    130                 135                 140                 


Leu His Pro Phe Leu Gln Arg Gln Gln Leu Ala Tyr Gly Ile Tyr Val 
145                 150                 155                 160 


Ile His Gln Ala Gly Asn Gly Thr Phe Asn Arg Ala Lys Leu Leu Asn 
                165                 170                 175     


Val Gly Val Arg Glu Ala Leu Arg Asp Glu Glu Trp Asp Cys Leu Phe 
            180                 185                 190         


Leu His Asp Val Asp Leu Leu Pro Glu Asn Asp His Asn Leu Tyr Val 
        195                 200                 205             


Cys Asp Pro Arg Gly Pro Arg His Val Ala Val Ala Met Asn Lys Phe 
    210                 215                 220                 


Gly Tyr Ser Leu Pro Tyr Pro Gln Tyr Phe Gly Gly Val Ser Ala Leu 
225                 230                 235                 240 


Thr Pro Asp Gln Tyr Leu Lys Met Asn Gly Phe Pro Asn Glu Tyr Trp 
                245                 250                 255     


Gly Trp Gly Gly Glu Asp Asp Asp Ile Ala Thr Arg Val Arg Leu Ala 
            260                 265                 270         


Gly Met Lys Ile Ser Arg Pro Pro Thr Ser Val Gly His Tyr Lys Met 
        275                 280                 285             


Val Lys His Arg Gly Asp Lys Gly Asn Glu Glu Asn Pro His Arg Phe 
    290                 295                 300                 


Asp Leu Leu Val Arg Thr Gln Asn Ser Trp Thr Gln Asp Gly Met Asn 
305                 310                 315                 320 


Ser Leu Thr Tyr Gln Leu Leu Ala Arg Glu Leu Gly Pro Leu Tyr Thr 
                325                 330                 335     


Asn Ile Thr Ala Asp Ile Gly Thr Asp Pro Arg Gly Pro Arg Ala Pro 
            340                 345                 350         


Ser Gly Pro Arg Tyr Pro Pro Gly Ser Ser Gln Ala Phe Arg Gln Glu 
        355                 360                 365             


Met Leu Gln Arg Arg Pro Pro Ala Arg Pro Gly Pro Leu Ser Thr Ala 
    370                 375                 380                 


Asn His Thr Ala Leu Arg Gly Ser His 
385                 390             


<210>  1027
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALT4__Homo_sapiens__NP_997708

<400>  1027

Met Gly Phe Asn Leu Thr Phe His Leu Ser Tyr Lys Phe Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Cys Leu Thr Val Val Gly Trp Ala Thr Ser Asn 
            20                  25                  30          


Tyr Phe Val Gly Ala Ile Gln Glu Ile Pro Lys Ala Lys Glu Phe Met 
        35                  40                  45              


Ala Asn Phe His Lys Thr Leu Ile Leu Gly Lys Gly Lys Thr Leu Thr 
    50                  55                  60                  


Asn Glu Ala Ser Thr Lys Lys Val Glu Leu Asp Asn Cys Pro Ser Val 
65                  70                  75                  80  


Ser Pro Tyr Leu Arg Gly Gln Ser Lys Leu Ile Phe Lys Pro Asp Leu 
                85                  90                  95      


Thr Leu Glu Glu Val Gln Ala Glu Asn Pro Lys Val Ser Arg Gly Arg 
            100                 105                 110         


Tyr Arg Pro Gln Glu Cys Lys Ala Leu Gln Arg Val Ala Ile Leu Val 
        115                 120                 125             


Pro His Arg Asn Arg Glu Lys His Leu Met Tyr Leu Leu Glu His Leu 
    130                 135                 140                 


His Pro Phe Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile 
145                 150                 155                 160 


His Gln Ala Glu Gly Lys Lys Phe Asn Arg Ala Lys Leu Leu Asn Val 
                165                 170                 175     


Gly Tyr Leu Glu Ala Leu Lys Glu Glu Asn Trp Asp Cys Phe Ile Phe 
            180                 185                 190         


His Asp Val Asp Leu Val Pro Glu Asn Asp Phe Asn Leu Tyr Lys Cys 
        195                 200                 205             


Glu Glu His Pro Lys His Leu Val Val Gly Arg Asn Ser Thr Gly Tyr 
    210                 215                 220                 


Arg Leu Arg Tyr Ser Gly Tyr Phe Gly Gly Val Thr Ala Leu Ser Arg 
225                 230                 235                 240 


Glu Gln Phe Phe Lys Val Asn Gly Phe Ser Asn Asn Tyr Trp Gly Trp 
                245                 250                 255     


Gly Gly Glu Asp Asp Asp Leu Arg Leu Arg Val Glu Leu Gln Arg Met 
            260                 265                 270         


Lys Ile Ser Arg Pro Leu Pro Glu Val Gly Lys Tyr Thr Met Val Phe 
        275                 280                 285             


His Thr Arg Asp Lys Gly Asn Glu Val Asn Ala Glu Arg Met Lys Leu 
    290                 295                 300                 


Leu His Gln Val Ser Arg Val Trp Arg Thr Asp Gly Leu Ser Ser Cys 
305                 310                 315                 320 


Ser Tyr Lys Leu Val Ser Val Glu His Asn Pro Leu Tyr Ile Asn Ile 
                325                 330                 335     


Thr Val Asp Phe Trp Phe Gly Ala 
            340                 


<210>  1028
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALT5__Homo_sapiens__NP_004767

<400>  1028

Met Arg Ala Arg Arg Gly Leu Leu Arg Leu Pro Arg Arg Ser Leu Leu 
1               5                   10                  15      


Ala Ala Leu Phe Phe Phe Ser Leu Ser Ser Ser Leu Leu Tyr Phe Val 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Val Asn Thr Tyr Leu Phe Met Met Gln Ala 
        35                  40                  45              


Gln Gly Ile Leu Ile Arg Asp Asn Val Arg Thr Ile Gly Ala Gln Val 
    50                  55                  60                  


Tyr Glu Gln Val Leu Arg Ser Ala Tyr Ala Lys Arg Asn Ser Ser Val 
65                  70                  75                  80  


Asn Asp Ser Asp Tyr Pro Leu Asp Leu Asn His Ser Glu Thr Phe Leu 
                85                  90                  95      


Gln Thr Thr Thr Phe Leu Pro Glu Asp Phe Thr Tyr Phe Ala Asn His 
            100                 105                 110         


Thr Cys Pro Glu Arg Leu Pro Ser Met Lys Gly Pro Ile Asp Ile Asn 
        115                 120                 125             


Met Ser Glu Ile Gly Met Asp Tyr Ile His Glu Leu Phe Ser Lys Asp 
    130                 135                 140                 


Pro Thr Ile Lys Leu Gly Gly His Trp Lys Pro Ser Asp Cys Met Pro 
145                 150                 155                 160 


Arg Trp Lys Val Ala Ile Leu Ile Pro Phe Arg Asn Arg His Glu His 
                165                 170                 175     


Leu Pro Val Leu Phe Arg His Leu Leu Pro Met Leu Gln Arg Gln Arg 
            180                 185                 190         


Leu Gln Phe Ala Phe Tyr Val Val Glu Gln Val Gly Thr Gln Pro Phe 
        195                 200                 205             


Asn Arg Ala Met Leu Phe Asn Val Gly Phe Gln Glu Ala Met Lys Asp 
    210                 215                 220                 


Leu Asp Trp Asp Cys Leu Ile Phe His Asp Val Asp His Ile Pro Glu 
225                 230                 235                 240 


Ser Asp Arg Asn Tyr Tyr Gly Cys Gly Gln Met Pro Arg His Phe Ala 
                245                 250                 255     


Thr Lys Leu Asp Lys Tyr Met Tyr Leu Leu Pro Tyr Thr Glu Phe Phe 
            260                 265                 270         


Gly Gly Val Ser Gly Leu Thr Val Glu Gln Phe Arg Lys Ile Asn Gly 
        275                 280                 285             


Phe Pro Asn Ala Phe Trp Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp 
    290                 295                 300                 


Asn Arg Val Gln Asn Ala Gly Tyr Ser Val Ser Arg Pro Glu Gly Asp 
305                 310                 315                 320 


Thr Gly Lys Tyr Lys Ser Ile Pro His His His Arg Gly Glu Val Gln 
                325                 330                 335     


Phe Leu Gly Arg Tyr Ala Leu Leu Arg Lys Ser Lys Glu Arg Gln Gly 
            340                 345                 350         


Leu Asp Gly Leu Asn Asn Leu Asn Tyr Phe Ala Asn Ile Thr Tyr Asp 
        355                 360                 365             


Ala Leu Tyr Lys Asn Ile Thr Val Asn Leu Thr Pro Glu Leu Ala Gln 
    370                 375                 380                 


Val Asn Glu Tyr 
385             


<210>  1029
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALT6__Homo_sapiens__NP_004766

<400>  1029

Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu 
1               5                   10                  15      


Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala 
        35                  40                  45              


Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile 
    50                  55                  60                  


Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly Thr Asp Tyr Pro 
65                  70                  75                  80  


Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu 
                85                  90                  95      


Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys Pro Glu Lys Leu 
            100                 105                 110         


Pro Tyr Met Arg Gly Phe Leu Asn Val Asn Val Ser Glu Val Ser Phe 
        115                 120                 125             


Asp Glu Ile His Gln Leu Phe Ser Lys Asp Leu Asp Ile Glu Pro Gly 
    130                 135                 140                 


Gly His Trp Arg Pro Lys Asp Cys Lys Pro Arg Trp Lys Val Ala Val 
145                 150                 155                 160 


Leu Ile Pro Phe Arg Asn Arg His Glu His Leu Pro Ile Phe Phe Leu 
                165                 170                 175     


His Leu Ile Pro Met Leu Gln Lys Gln Arg Leu Glu Phe Ala Phe Tyr 
            180                 185                 190         


Val Ile Glu Gln Thr Gly Thr Gln Pro Phe Asn Arg Ala Met Leu Phe 
        195                 200                 205             


Asn Val Gly Phe Lys Glu Ala Met Lys Asp Ser Val Trp Asp Cys Val 
    210                 215                 220                 


Ile Phe His Asp Val Asp His Leu Pro Glu Asn Asp Arg Asn Tyr Tyr 
225                 230                 235                 240 


Gly Cys Gly Glu Met Pro Arg His Phe Ala Ala Lys Leu Asp Lys Tyr 
                245                 250                 255     


Met Tyr Ile Leu Pro Tyr Lys Glu Phe Phe Gly Gly Val Ser Gly Leu 
            260                 265                 270         


Thr Val Glu Gln Phe Arg Lys Ile Asn Gly Phe Pro Asn Ala Phe Trp 
        275                 280                 285             


Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp Asn Arg Val His Tyr Ala 
    290                 295                 300                 


Gly Tyr Asn Val Thr Arg Pro Glu Gly Asp Leu Gly Lys Tyr Lys Ser 
305                 310                 315                 320 


Ile Pro His His His Arg Gly Glu Val Gln Phe Leu Gly Arg Tyr Lys 
                325                 330                 335     


Leu Leu Arg Tyr Ser Lys Glu Arg Gln Tyr Ile Asp Gly Leu Asn Asn 
            340                 345                 350         


Leu Ile Tyr Arg Pro Lys Ile Leu Val Asp Arg Leu Tyr Thr Asn Ile 
        355                 360                 365             


Ser Val Asn Leu Met Pro Glu Leu Ala Pro Ile Glu Asp Tyr 
    370                 375                 380         


<210>  1030
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GALT7__Homo_sapiens__NP_009186

<400>  1030

Met Phe Pro Ser Arg Arg Lys Ala Ala Gln Leu Pro Trp Glu Asp Gly 
1               5                   10                  15      


Arg Ser Gly Leu Leu Ser Gly Gly Leu Pro Arg Lys Cys Ser Val Phe 
            20                  25                  30          


His Leu Phe Val Ala Cys Leu Ser Leu Gly Phe Phe Ser Leu Leu Trp 
        35                  40                  45              


Leu Gln Leu Ser Cys Ser Gly Asp Val Ala Arg Ala Val Arg Gly Gln 
    50                  55                  60                  


Gly Gln Glu Thr Ser Gly Pro Pro Arg Ala Cys Pro Pro Glu Pro Pro 
65                  70                  75                  80  


Pro Glu His Trp Glu Glu Asp Ala Ser Trp Gly Pro His Arg Leu Ala 
                85                  90                  95      


Val Leu Val Pro Phe Arg Glu Arg Phe Glu Glu Leu Leu Val Phe Val 
            100                 105                 110         


Pro His Met Arg Arg Phe Leu Ser Arg Lys Lys Ile Arg His His Ile 
        115                 120                 125             


Tyr Val Leu Asn Gln Val Asp His Phe Arg Phe Asn Arg Ala Ala Leu 
    130                 135                 140                 


Ile Asn Val Gly Phe Leu Glu Ser Ser Asn Ser Thr Asp Tyr Ile Ala 
145                 150                 155                 160 


Met His Asp Val Asp Leu Leu Pro Leu Asn Glu Glu Leu Asp Tyr Gly 
                165                 170                 175     


Phe Pro Glu Ala Gly Pro Phe His Val Ala Ser Pro Glu Leu His Pro 
            180                 185                 190         


Leu Tyr His Tyr Lys Thr Tyr Val Gly Gly Ile Leu Leu Leu Ser Lys 
        195                 200                 205             


Gln His Tyr Arg Leu Cys Asn Gly Met Ser Asn Arg Phe Trp Gly Trp 
    210                 215                 220                 


Gly Arg Glu Asp Asp Glu Phe Tyr Arg Arg Ile Lys Gly Ala Gly Leu 
225                 230                 235                 240 


Gln Leu Phe Arg Pro Ser Gly Ile Thr Thr Gly Tyr Lys Thr Phe Arg 
                245                 250                 255     


His Leu His Asp Pro Ala Trp Arg Lys Arg Asp Gln Lys Arg Ile Ala 
            260                 265                 270         


Ala Gln Lys Gln Glu Gln Phe Lys Val Asp Arg Glu Gly Gly Leu Asn 
        275                 280                 285             


Thr Val Lys Tyr His Val Ala Ser Arg Thr Ala Leu Ser Val Gly Gly 
    290                 295                 300                 


Ala Pro Cys Thr Val Leu Asn Ile Met Leu Asp Cys Asp Lys Thr Ala 
305                 310                 315                 320 


Thr Pro Trp Cys Thr Phe Ser 
                325         


<210>  1031
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4GAT1__Homo_sapiens__NP_006867

<400>  1031

Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu 
            20                  25                  30          


Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe 
        35                  40                  45              


Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg 
    50                  55                  60                  


Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg 
65                  70                  75                  80  


Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile 
                85                  90                  95      


Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu 
            100                 105                 110         


Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr 
        115                 120                 125             


Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser 
    130                 135                 140                 


His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro 
145                 150                 155                 160 


Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe 
                165                 170                 175     


Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val 
            180                 185                 190         


Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro 
        195                 200                 205             


Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu 
    210                 215                 220                 


Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu 
225                 230                 235                 240 


Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val 
                245                 250                 255     


Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys 
            260                 265                 270         


Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr 
        275                 280                 285             


Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp 
    290                 295                 300                 


Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro 
305                 310                 315                 320 


Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro 
                325                 330                 335     


Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln 
            340                 345                 350         


Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu 
        355                 360                 365             


Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro 
    370                 375                 380                 


Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe 
385                 390                 395                 400 


Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys 
                405                 410                 415 


<210>  1032
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B9D1__Homo_sapiens__NP_001230404

<400>  1032

Met Met Thr Ser Thr Ala Ser Thr Ala Leu Cys Thr Ala Arg Thr Gly 
1               5                   10                  15      


Pro Pro Gln Arg Val Trp Arg Arg Gly Ser His Arg Ser His Pro Arg 
            20                  25                  30          


Ala Lys Met Cys Gly Lys His Trp Cys Gly Thr Ser Pro Leu Met Ser 
        35                  40                  45              


Pro Leu Lys Ala Pro Thr Pro Thr Ala Gly His Arg Ser Cys Ser Ala 
    50                  55                  60                  


Cys Met Asp Gln Met Cys Ser Gly Thr Met Trp Phe Glu Ala Met Gly 
65                  70                  75                  80  


Pro Cys Thr Cys Pro Ser His Leu Ala Gly Thr Lys Gly Pro Ser Pro 
                85                  90                  95      


Cys Leu Ser Gln Asn Leu Arg Leu Asn Cys Arg Ser Leu Gln Ala Gly 
            100                 105                 110         


Ser Trp Gly Gly Gly Pro Ser Thr Gln Thr Pro Arg Trp Trp Leu Arg 
        115                 120                 125             


Val Lys Ala Gly Lys Pro Pro Ser Gly Leu Ser Val Lys Asp Ser Ser 
    130                 135                 140                 


Val Ser Arg 
145         


<210>  1033
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B9D2__Homo_sapiens__NP_085055

<400>  1033

Met Ala Glu Val His Val Ile Gly Gln Ile Ile Gly Ala Ser Gly Phe 
1               5                   10                  15      


Ser Glu Ser Ser Leu Phe Cys Lys Trp Gly Ile His Thr Gly Ala Ala 
            20                  25                  30          


Trp Lys Leu Leu Ser Gly Val Arg Glu Gly Gln Thr Gln Val Asp Thr 
        35                  40                  45              


Pro Gln Ile Gly Asp Met Ala Tyr Trp Ser His Pro Ile Asp Leu His 
    50                  55                  60                  


Phe Ala Thr Lys Gly Leu Gln Gly Trp Pro Arg Leu His Phe Gln Val 
65                  70                  75                  80  


Trp Ser Gln Asp Ser Phe Gly Arg Cys Gln Leu Ala Gly Tyr Gly Phe 
                85                  90                  95      


Cys His Val Pro Ser Ser Pro Gly Thr His Gln Leu Ala Cys Pro Thr 
            100                 105                 110         


Trp Arg Pro Leu Gly Ser Trp Arg Glu Gln Leu Ala Arg Ala Phe Val 
        115                 120                 125             


Gly Gly Gly Pro Gln Leu Leu His Gly Asp Thr Ile Tyr Ser Gly Ala 
    130                 135                 140                 


Asp Arg Tyr Arg Leu His Thr Ala Ala Gly Gly Thr Val His Leu Glu 
145                 150                 155                 160 


Ile Gly Leu Leu Leu Arg Asn Phe Asp Arg Tyr Gly Val Glu Cys 
                165                 170                 175 


<210>  1034
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAALC__Homo_sapiens__NP_001019543

<400>  1034

Met Gly Cys Gly Gly Ser Arg Ala Asp Ala Ile Glu Pro Arg Tyr Tyr 
1               5                   10                  15      


Glu Ser Trp Thr Arg Glu Thr Glu Ser Thr Trp Leu Thr Tyr Thr Asp 
            20                  25                  30          


Ser Asp Ala Pro Pro Ser Ala Ala Ala Pro Asp Ser Gly Pro Glu Ala 
        35                  40                  45              


Gly Gly Leu His Ser Gly 
    50                  


<210>  1035
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAAT__Homo_sapiens__NP_001692

<400>  1035

Met Ile Gln Leu Thr Ala Thr Pro Val Ser Ala Leu Val Asp Glu Pro 
1               5                   10                  15      


Val His Ile Arg Ala Thr Gly Leu Ile Pro Phe Gln Met Val Ser Phe 
            20                  25                  30          


Gln Ala Ser Leu Glu Asp Glu Asn Gly Asp Met Phe Tyr Ser Gln Ala 
        35                  40                  45              


His Tyr Arg Ala Asn Glu Phe Gly Glu Val Asp Leu Asn His Ala Ser 
    50                  55                  60                  


Ser Leu Gly Gly Asp Tyr Met Gly Val His Pro Met Gly Leu Phe Trp 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Lys Leu Leu Thr Arg Leu Leu Lys Arg Asp Val 
                85                  90                  95      


Met Asn Arg Pro Phe Gln Val Gln Val Lys Leu Tyr Asp Leu Glu Leu 
            100                 105                 110         


Ile Val Asn Asn Lys Val Ala Ser Ala Pro Lys Ala Ser Leu Thr Leu 
        115                 120                 125             


Glu Arg Trp Tyr Val Ala Pro Gly Val Thr Arg Ile Lys Val Arg Glu 
    130                 135                 140                 


Gly Arg Leu Arg Gly Ala Leu Phe Leu Pro Pro Gly Glu Gly Leu Phe 
145                 150                 155                 160 


Pro Gly Val Ile Asp Leu Phe Gly Gly Leu Gly Gly Leu Leu Glu Phe 
                165                 170                 175     


Arg Ala Ser Leu Leu Ala Ser Arg Gly Phe Ala Ser Leu Ala Leu Ala 
            180                 185                 190         


Tyr His Asn Tyr Glu Asp Leu Pro Arg Lys Pro Glu Val Thr Asp Leu 
        195                 200                 205             


Glu Tyr Phe Glu Glu Ala Ala Asn Phe Leu Leu Arg His Pro Lys Val 
    210                 215                 220                 


Phe Gly Ser Gly Val Gly Val Val Ser Val Cys Gln Gly Val Gln Ile 
225                 230                 235                 240 


Gly Leu Ser Met Ala Ile Tyr Leu Lys Gln Val Thr Ala Thr Val Leu 
                245                 250                 255     


Ile Asn Gly Thr Asn Phe Pro Phe Gly Ile Pro Gln Val Tyr His Gly 
            260                 265                 270         


Gln Ile His Gln Pro Leu Pro His Ser Ala Gln Leu Ile Ser Thr Asn 
        275                 280                 285             


Ala Leu Gly Leu Leu Glu Leu Tyr Arg Thr Phe Glu Thr Thr Gln Val 
    290                 295                 300                 


Gly Ala Ser Gln Tyr Leu Phe Pro Ile Glu Glu Ala Gln Gly Gln Phe 
305                 310                 315                 320 


Leu Phe Ile Val Gly Glu Gly Asp Lys Thr Ile Asn Ser Lys Ala His 
                325                 330                 335     


Ala Glu Gln Ala Ile Gly Gln Leu Lys Arg His Gly Lys Asn Asn Trp 
            340                 345                 350         


Thr Leu Leu Ser Tyr Pro Gly Ala Gly His Leu Ile Glu Pro Pro Tyr 
        355                 360                 365             


Ser Pro Leu Cys Cys Ala Ser Thr Thr His Asp Leu Arg Leu His Trp 
    370                 375                 380                 


Gly Gly Glu Val Ile Pro His Ala Ala Ala Gln Glu His Ala Trp Lys 
385                 390                 395                 400 


Glu Ile Gln Arg Phe Leu Arg Lys His Leu Ile Pro Asp Val Thr Ser 
                405                 410                 415     


Gln Leu 
        


<210>  1036
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BABAM1__Homo_sapiens__NP_001275685

<400>  1036

Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu 
            20                  25                  30          


Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser Arg 
        35                  40                  45              


Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn 
    50                  55                  60                  


Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala Pro 
65                  70                  75                  80  


Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val Ile 
                85                  90                  95      


Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser 
            100                 105                 110         


Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys Met Ile 
        115                 120                 125             


Glu Met Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His Glu Phe 
    130                 135                 140                 


Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu Thr 
145                 150                 155                 160 


Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr Ala 
                165                 170                 175     


Ser Cys Ser Thr Phe Asn Leu Glu Gly Leu Phe Ser Leu Ile Gln Gln 
            180                 185                 190         


Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro Pro Pro 
        195                 200                 205             


Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys Gln Pro 
    210                 215                 220                 


Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys Pro Tyr 
225                 230                 235                 240 


Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu Lys Glu 
                245                 250                 255     


Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu Asp 
            260                 265                 270         


Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro Ala 
        275                 280                 285             


Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu Gln 
    290                 295                 300                 


Arg Pro Cys Gln Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu Asp 
305                 310                 315                 320 


Glu Ala Ile Glu Val Glu Ala Thr Val 
                325                 


<210>  1037
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BACE1__Homo_sapiens__NP_001193978

<400>  1037

Met Val Pro Phe Ile Tyr Leu Gln Ala His Phe Thr Leu Cys Ser Gly 
1               5                   10                  15      


Trp Ser Ser Thr Tyr Arg Asp Leu Arg Lys Gly Val Tyr Val Pro Tyr 
            20                  25                  30          


Thr Gln Gly Lys Trp Glu Gly Glu Leu Gly Thr Asp Leu Val Ser Ile 
        35                  40                  45              


Pro His Gly Pro Asn Val Thr Val Arg Ala Asn Ile Ala Ala Ile Thr 
    50                  55                  60                  


Glu Ser Asp Lys Phe Phe Ile Asn Gly Ser Asn Trp Glu Gly Ile Leu 
65                  70                  75                  80  


Gly Leu Ala Tyr Ala Glu Ile Ala Arg Leu Cys Gly Ala Gly Phe Pro 
                85                  90                  95      


Leu Asn Gln Ser Glu Val Leu Ala Ser Val Gly Gly Ser Met Ile Ile 
            100                 105                 110         


Gly Gly Ile Asp His Ser Leu Tyr Thr Gly Ser Leu Trp Tyr Thr Pro 
        115                 120                 125             


Ile Arg Arg Glu Trp Tyr Tyr Glu Val Ile Ile Val Arg Val Glu Ile 
    130                 135                 140                 


Asn Gly Gln Asp Leu Lys Met Asp Cys Lys Glu Tyr Asn Tyr Asp Lys 
145                 150                 155                 160 


Ser Ile Val Asp Ser Gly Thr Thr Asn Leu Arg Leu Pro Lys Lys Val 
                165                 170                 175     


Phe Glu Ala Ala Val Lys Ser Ile Lys Ala Ala Ser Ser Thr Glu Lys 
            180                 185                 190         


Phe Pro Asp Gly Phe Trp Leu Gly Glu Gln Leu Val Cys Trp Gln Ala 
        195                 200                 205             


Gly Thr Thr Pro Trp Asn Ile Phe Pro Val Ile Ser Leu Tyr Leu Met 
    210                 215                 220                 


Gly Glu Val Thr Asn Gln Ser Phe Arg Ile Thr Ile Leu Pro Gln Gln 
225                 230                 235                 240 


Tyr Leu Arg Pro Val Glu Asp Val Ala Thr Ser Gln Asp Asp Cys Tyr 
                245                 250                 255     


Lys Phe Ala Ile Ser Gln Ser Ser Thr Gly Thr Val Met Gly Ala Val 
            260                 265                 270         


Ile Met Glu Gly Phe Tyr Val Val Phe Asp Arg Ala Arg Lys Arg Ile 
        275                 280                 285             


Gly Phe Ala Val Ser Ala Cys His Val His Asp Glu Phe Arg Thr Ala 
    290                 295                 300                 


Ala Val Glu Gly Pro Phe Val Thr Leu Asp Met Glu Asp Cys Gly Tyr 
305                 310                 315                 320 


Asn Ile Pro Gln Thr Asp Glu Ser Thr Leu Met Thr Ile Ala Tyr Val 
                325                 330                 335     


Met Ala Ala Ile Cys Ala Leu Phe Met Leu Pro Leu Cys Leu Met Val 
            340                 345                 350         


Cys Gln Trp Arg Cys Leu Arg Cys Leu Arg Gln Gln His Asp Asp Phe 
        355                 360                 365             


Ala Asp Asp Ile Ser Leu Leu Lys 
    370                 375     


<210>  1038
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BACE2__Homo_sapiens__NP_036237

<400>  1038

Met Gly Ala Leu Ala Arg Ala Leu Leu Leu Pro Leu Leu Ala Gln Trp 
1               5                   10                  15      


Leu Leu Arg Ala Ala Pro Glu Leu Ala Pro Ala Pro Phe Thr Leu Pro 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Thr Asn Arg Val Val Ala Pro Thr Pro Gly 
        35                  40                  45              


Pro Gly Thr Pro Ala Glu Arg His Ala Asp Gly Leu Ala Leu Ala Leu 
    50                  55                  60                  


Glu Pro Ala Leu Ala Ser Pro Ala Gly Ala Ala Asn Phe Leu Ala Met 
65                  70                  75                  80  


Val Asp Asn Leu Gln Gly Asp Ser Gly Arg Gly Tyr Tyr Leu Glu Met 
                85                  90                  95      


Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr Gly 
            100                 105                 110         


Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp Thr 
        115                 120                 125             


Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe Asp 
    130                 135                 140                 


Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly Glu 
145                 150                 155                 160 


Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val Asn 
                165                 170                 175     


Ile Ala Thr Ile Phe Glu Ser Glu Asn Phe Phe Leu Pro Gly Ile Lys 
            180                 185                 190         


Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro Ser 
        195                 200                 205             


Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn Ile 
    210                 215                 220                 


Pro Asn Val Phe Ser Met Gln Met Cys Gly Ala Gly Leu Pro Val Ala 
225                 230                 235                 240 


Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu Pro 
                245                 250                 255     


Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu Trp 
            260                 265                 270         


Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser Leu 
        275                 280                 285             


Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp Ser 
    290                 295                 300                 


Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val Val 
305                 310                 315                 320 


Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp Gly Phe 
                325                 330                 335     


Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr Pro Trp 
            340                 345                 350         


Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn Ser Ser 
        355                 360                 365             


Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Leu Tyr Ile Gln Pro Met 
    370                 375                 380                 


Met Gly Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile Ser Pro 
385                 390                 395                 400 


Ser Thr Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly Phe Tyr 
                405                 410                 415     


Val Ile Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala Ser Pro 
            420                 425                 430         


Cys Ala Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly Pro Phe 
        435                 440                 445             


Ser Thr Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser Leu Ser 
    450                 455                 460                 


Glu Pro Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val Cys Gly 
465                 470                 475                 480 


Ala Ile Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe Arg Cys 
                485                 490                 495     


Gln Arg Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser Ser Leu 
            500                 505                 510         


Val Arg His Arg Trp Lys 
        515             


<210>  1039
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BACH1__Homo_sapiens__NP_996749

<400>  1039

Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Thr Asn Val Leu Leu Ser Leu Asn Asp Gln Arg Lys Lys Asp Val 
            20                  25                  30          


Leu Cys Asp Val Thr Ile Phe Val Glu Gly Gln Arg Phe Arg Ala His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Ser Tyr Phe His Ser Arg Ile Val 
    50                  55                  60                  


Gly Gln Ala Asp Gly Glu Leu Asn Ile Thr Leu Pro Glu Glu Val Thr 
65                  70                  75                  80  


Val Lys Gly Phe Glu Pro Leu Ile Gln Phe Ala Tyr Thr Ala Lys Leu 
                85                  90                  95      


Ile Leu Ser Lys Glu Asn Val Asp Glu Val Cys Lys Cys Val Glu Phe 
            100                 105                 110         


Leu Ser Val His Asn Ile Glu Glu Ser Cys Phe Gln Phe Leu Lys Phe 
        115                 120                 125             


Lys Phe Leu Asp Ser Thr Ala Asp Gln Gln Glu Cys Pro Arg Lys Lys 
    130                 135                 140                 


Cys Phe Ser Ser His Cys Gln Lys Thr Asp Leu Lys Leu Ser Leu Leu 
145                 150                 155                 160 


Asp Gln Arg Asp Leu Glu Thr Asp Glu Val Glu Glu Phe Leu Glu Asn 
                165                 170                 175     


Lys Asn Val Gln Thr Pro Gln Cys Lys Leu Arg Arg Tyr Gln Gly Asn 
            180                 185                 190         


Ala Lys Ala Ser Pro Pro Leu Gln Asp Ser Ala Ser Gln Thr Tyr Glu 
        195                 200                 205             


Ser Met Cys Leu Glu Lys Asp Ala Ala Leu Ala Leu Pro Ser Leu Cys 
    210                 215                 220                 


Pro Lys Tyr Arg Lys Phe Gln Lys Ala Phe Gly Thr Asp Arg Val Arg 
225                 230                 235                 240 


Thr Gly Glu Ser Ser Val Lys Asp Ile His Ala Ser Val Gln Pro Asn 
                245                 250                 255     


Glu Arg Ser Glu Asn Glu Cys Leu Gly Gly Val Pro Glu Cys Arg Asp 
            260                 265                 270         


Leu Gln Val Met Leu Lys Cys Asp Glu Ser Lys Leu Ala Met Glu Pro 
        275                 280                 285             


Glu Glu Thr Lys Lys Asp Pro Ala Ser Gln Cys Pro Thr Glu Lys Ser 
    290                 295                 300                 


Glu Val Thr Pro Phe Pro His Asn Ser Ser Ile Asp Pro His Gly Leu 
305                 310                 315                 320 


Tyr Ser Leu Ser Leu Leu His Thr Tyr Asp Gln Tyr Gly Asp Leu Asn 
                325                 330                 335     


Phe Ala Gly Met Gln Asn Thr Thr Val Leu Thr Glu Lys Pro Leu Ser 
            340                 345                 350         


Gly Thr Asp Val Gln Glu Lys Thr Phe Gly Glu Ser Gln Asp Leu Pro 
        355                 360                 365             


Leu Lys Ser Asp Leu Gly Thr Arg Glu Asp Ser Ser Val Ala Ser Ser 
    370                 375                 380                 


Asp Arg Ser Ser Val Glu Arg Glu Val Ala Glu His Leu Ala Lys Gly 
385                 390                 395                 400 


Phe Trp Ser Asp Ile Cys Ser Thr Asp Thr Pro Cys Gln Met Gln Leu 
                405                 410                 415     


Ser Pro Ala Val Ala Lys Asp Gly Ser Glu Gln Ile Ser Gln Lys Arg 
            420                 425                 430         


Ser Glu Cys Pro Trp Leu Gly Ile Arg Ile Ser Glu Ser Pro Glu Pro 
        435                 440                 445             


Gly Gln Arg Thr Phe Thr Thr Leu Ser Ser Val Asn Cys Pro Phe Ile 
    450                 455                 460                 


Ser Thr Leu Ser Thr Glu Gly Cys Ser Ser Asn Leu Glu Ile Gly Asn 
465                 470                 475                 480 


Asp Asp Tyr Val Ser Glu Pro Gln Gln Glu Pro Cys Pro Tyr Ala Cys 
                485                 490                 495     


Val Ile Ser Leu Gly Asp Asp Ser Glu Thr Asp Thr Glu Gly Asp Ser 
            500                 505                 510         


Glu Ser Cys Ser Ala Arg Glu Gln Glu Cys Glu Val Lys Leu Pro Phe 
        515                 520                 525             


Asn Ala Gln Arg Ile Ile Ser Leu Ser Arg Asn Asp Phe Gln Ser Leu 
    530                 535                 540                 


Leu Lys Met His Lys Leu Thr Pro Glu Gln Leu Asp Cys Ile His Asp 
545                 550                 555                 560 


Ile Arg Arg Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys 
                565                 570                 575     


Arg Lys Leu Asp Cys Ile Gln Asn Leu Glu Ser Glu Ile Glu Lys Leu 
            580                 585                 590         


Gln Ser Glu Lys Glu Ser Leu Leu Lys Glu Arg Asp His Ile Leu Ser 
        595                 600                 605             


Thr Leu Gly Glu Thr Lys Gln Asn Leu Thr Gly Leu Cys Gln Lys Val 
    610                 615                 620                 


Cys Lys Glu Ala Ala Leu Ser Gln Glu Gln Ile Gln Ile Leu Ala Lys 
625                 630                 635                 640 


Tyr Ser Ala Ala Asp Cys Pro Leu Ser Phe Leu Ile Ser Glu Lys Asp 
                645                 650                 655     


Lys Ser Thr Pro Asp Gly Glu Leu Ala Leu Pro Ser Ile Phe Ser Leu 
            660                 665                 670         


Ser Asp Arg Pro Pro Ala Val Leu Pro Pro Cys Ala Arg Gly Asn Ser 
        675                 680                 685             


Glu Pro Gly Tyr Ala Arg Gly Gln Glu Ser Gln Gln Met Ser Thr Ala 
    690                 695                 700                 


Thr Ser Glu Gln Ala Gly Pro Ala Glu Gln Cys Arg Gln Ser Gly Gly 
705                 710                 715                 720 


Ile Ser Asp Phe Cys Gln Gln Met Thr Asp Lys Cys Thr Thr Asp Glu 
                725                 730                 735     


<210>  1040
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BACH2__Homo_sapiens__XP_005248815

<400>  1040

Met Ser Arg His Thr Gly Lys Arg Arg Lys Thr Gln Val Glu Glu Thr 
1               5                   10                  15      


Ser Gln Ile Ser Arg Asn Trp Asn Val Phe Lys Ser Trp Gln Ser Gln 
            20                  25                  30          


Gly Val Asn Gly Met Ser Val Asp Glu Lys Pro Asp Ser Pro Met Tyr 
        35                  40                  45              


Val Tyr Glu Ser Thr Val His Cys Thr Asn Ile Leu Leu Gly Leu Asn 
    50                  55                  60                  


Asp Gln Arg Lys Lys Asp Ile Leu Cys Asp Val Thr Leu Ile Val Glu 
65                  70                  75                  80  


Arg Lys Glu Phe Arg Ala His Arg Ala Val Leu Ala Ala Cys Ser Glu 
                85                  90                  95      


Tyr Phe Trp Gln Ala Leu Val Gly Gln Thr Lys Asn Asp Leu Val Val 
            100                 105                 110         


Ser Leu Pro Glu Glu Val Thr Ala Arg Gly Phe Gly Pro Leu Leu Gln 
        115                 120                 125             


Phe Ala Tyr Thr Ala Lys Leu Leu Leu Ser Arg Glu Asn Ile Arg Glu 
    130                 135                 140                 


Val Ile Arg Cys Ala Glu Phe Leu Arg Met His Asn Leu Glu Asp Ser 
145                 150                 155                 160 


Cys Phe Ser Phe Leu Gln Thr Gln Leu Leu Asn Ser Glu Asp Gly Leu 
                165                 170                 175     


Phe Val Cys Arg Lys Asp Ala Ala Cys Gln Arg Pro His Glu Asp Cys 
            180                 185                 190         


Glu Asn Ser Ala Gly Glu Glu Glu Asp Glu Glu Glu Glu Thr Met Asp 
        195                 200                 205             


Ser Glu Thr Ala Lys Met Ala Cys Pro Arg Asp Gln Met Leu Pro Glu 
    210                 215                 220                 


Pro Ile Ser Phe Glu Ala Ala Ala Ile Pro Val Ala Glu Lys Glu Glu 
225                 230                 235                 240 


Ala Leu Leu Pro Glu Pro Asp Val Pro Thr Asp Thr Lys Glu Ser Ser 
                245                 250                 255     


Glu Lys Asp Ala Leu Thr Gln Tyr Pro Arg Tyr Lys Lys Tyr Gln Leu 
            260                 265                 270         


Ala Cys Thr Lys Asn Val Tyr Asn Ala Ser Ser His Ser Thr Ser Gly 
        275                 280                 285             


Phe Ala Ser Thr Phe Arg Glu Asp Asn Ser Ser Asn Ser Leu Lys Pro 
    290                 295                 300                 


Gly Leu Ala Arg Gly Gln Ile Lys Ser Glu Pro Pro Ser Glu Glu Asn 
305                 310                 315                 320 


Glu Glu Glu Ser Ile Thr Leu Cys Leu Ser Gly Asp Glu Pro Asp Ala 
                325                 330                 335     


Lys Asp Arg Ala Gly Asp Val Glu Met Asp Arg Lys Gln Pro Ser Pro 
            340                 345                 350         


Ala Pro Thr Pro Thr Ala Pro Ala Gly Ala Ala Cys Leu Glu Arg Ser 
        355                 360                 365             


Arg Ser Val Ala Ser Pro Ser Cys Leu Arg Ser Leu Phe Ser Ile Thr 
    370                 375                 380                 


Lys Ser Val Glu Leu Ser Gly Leu Pro Ser Thr Ser Gln Gln His Phe 
385                 390                 395                 400 


Ala Arg Ser Pro Ala Cys Pro Phe Asp Lys Gly Ile Thr Gln Gly Asp 
                405                 410                 415     


Leu Lys Thr Asp Tyr Thr Pro Phe Thr Gly Asn Tyr Gly Gln Pro His 
            420                 425                 430         


Val Gly Gln Lys Glu Val Ser Asn Phe Thr Met Gly Ser Pro Leu Arg 
        435                 440                 445             


Gly Pro Gly Leu Glu Ala Leu Cys Lys Gln Glu Gly Glu Leu Asp Arg 
    450                 455                 460                 


Arg Ser Val Ile Phe Ser Ser Ser Ala Cys Asp Gln Val Ser Thr Ser 
465                 470                 475                 480 


Val His Ser Tyr Ser Gly Val Ser Ser Leu Asp Lys Asp Leu Ser Glu 
                485                 490                 495     


Pro Val Pro Lys Gly Leu Trp Val Gly Ala Gly Gln Ser Leu Pro Ser 
            500                 505                 510         


Ser Gln Ala Tyr Ser His Gly Gly Leu Met Ala Asp His Leu Pro Gly 
        515                 520                 525             


Arg Met Arg Pro Asn Thr Ser Cys Pro Val Pro Ile Lys Val Cys Pro 
    530                 535                 540                 


Arg Ser Pro Pro Leu Glu Thr Arg Thr Arg Thr Ser Ser Ser Cys Ser 
545                 550                 555                 560 


Ser Tyr Ser Tyr Ala Glu Asp Gly Ser Gly Gly Ser Pro Cys Ser Leu 
                565                 570                 575     


Pro Leu Cys Glu Phe Ser Ser Ser Pro Cys Ser Gln Gly Ala Arg Phe 
            580                 585                 590         


Leu Ala Thr Glu His Gln Glu Pro Gly Leu Met Gly Asp Gly Met Tyr 
        595                 600                 605             


Asn Gln Val Arg Pro Gln Ile Lys Cys Glu Gln Ser Tyr Gly Thr Asn 
    610                 615                 620                 


Ser Ser Asp Glu Ser Gly Ser Phe Ser Glu Ala Asp Ser Glu Ser Cys 
625                 630                 635                 640 


Pro Val Gln Asp Arg Gly Gln Glu Val Lys Leu Pro Phe Pro Val Asp 
                645                 650                 655     


Gln Ile Thr Asp Leu Pro Arg Asn Asp Phe Gln Met Met Ile Lys Met 
            660                 665                 670         


His Lys Leu Thr Ser Glu Gln Leu Glu Phe Ile His Asp Val Arg Arg 
        675                 680                 685             


Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys Arg Lys Leu 
    690                 695                 700                 


Asp Cys Ile Gln Asn Leu Glu Cys Glu Ile Arg Lys Leu Val Cys Glu 
705                 710                 715                 720 


Lys Glu Lys Leu Leu Ser Glu Arg Asn Gln Leu Lys Ala Cys Met Gly 
                725                 730                 735     


Glu Leu Leu Asp Asn Phe Ser Cys Leu Ser Gln Glu Val Cys Arg Asp 
            740                 745                 750         


Ile Gln Ser Pro Glu Gln Ile Gln Ala Leu His Arg Tyr Cys Pro Val 
        755                 760                 765             


Leu Arg Pro Met Asp Leu Pro Thr Ala Ser Ser Ile Asn Pro Ala Pro 
    770                 775                 780                 


Leu Gly Ala Glu Gln Asn Ile Ala Ala Ser Gln Cys Ala Val Gly Glu 
785                 790                 795                 800 


Asn Val Pro Cys Cys Leu Glu Pro Gly Ala Ala Pro Pro Gly Pro Pro 
                805                 810                 815     


Trp Ala Pro Ser Asn Thr Ser Glu Asn Cys Thr Ser Gly Arg Arg Leu 
            820                 825                 830         


Glu Gly Thr Asp Pro Gly Thr Phe Ser Glu Arg Gly Pro Pro Leu Glu 
        835                 840                 845             


Pro Arg Ser Gln Thr Val Thr Val Asp Phe Cys Gln Glu Met Thr Asp 
    850                 855                 860                 


Lys Cys Thr Thr Asp Glu Gln Pro Arg Lys Asp Tyr Thr 
865                 870                 875         


<210>  1041
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAD__Homo_sapiens__NP_004313

<400>  1041

Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210>  1042
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAG1__Homo_sapiens__NP_001165886

<400>  1042

Met Asn Arg Ser Gln Glu Val Thr Arg Asp Glu Glu Ser Thr Arg Ser 
1               5                   10                  15      


Glu Glu Val Thr Arg Glu Glu Met Ala Ala Ala Gly Leu Thr Val Thr 
            20                  25                  30          


Val Thr His Ser Asn Glu Lys His Asp Leu His Val Thr Ser Gln Gln 
        35                  40                  45              


Gly Ser Ser Glu Pro Val Val Gln Asp Leu Ala Gln Val Val Glu Glu 
    50                  55                  60                  


Val Ile Gly Val Pro Gln Ser Phe Gln Lys Leu Ile Phe Lys Gly Lys 
65                  70                  75                  80  


Ser Leu Lys Glu Met Glu Thr Pro Leu Ser Ala Leu Gly Ile Gln Asp 
                85                  90                  95      


Gly Cys Arg Val Met Leu Ile Gly Lys Lys Asn Ser Pro Gln Glu Glu 
            100                 105                 110         


Val Glu Leu Lys Lys Leu Lys His Leu Glu Lys Ser Val Glu Lys Ile 
        115                 120                 125             


Ala Asp Gln Leu Glu Glu Leu Asn Lys Glu Leu Thr Gly Ile Gln Gln 
    130                 135                 140                 


Gly Phe Leu Pro Lys Asp Leu Gln Ala Glu Ala Leu Cys Lys Leu Asp 
145                 150                 155                 160 


Arg Arg Val Lys Ala Thr Ile Glu Gln Phe Met Lys Ile Leu Glu Glu 
                165                 170                 175     


Ile Asp Thr Leu Ile Leu Pro Glu Asn Phe Lys Asp Ser Arg Leu Lys 
            180                 185                 190         


Arg Lys Gly Leu Val Lys Lys Val Gln Ala Phe Leu Ala Glu Cys Asp 
        195                 200                 205             


Thr Val Glu Gln Asn Ile Cys Gln Glu Thr Glu Arg Leu Gln Ser Thr 
    210                 215                 220                 


Asn Phe Ala Leu Ala Glu 
225                 230 


<210>  1043
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAG3__Homo_sapiens__NP_004272

<400>  1043

Met Ser Ala Ala Thr His Ser Pro Met Met Gln Val Ala Ser Gly Asn 
1               5                   10                  15      


Gly Asp Arg Asp Pro Leu Pro Pro Gly Trp Glu Ile Lys Ile Asp Pro 
            20                  25                  30          


Gln Thr Gly Trp Pro Phe Phe Val Asp His Asn Ser Arg Thr Thr Thr 
        35                  40                  45              


Trp Asn Asp Pro Arg Val Pro Ser Glu Gly Pro Lys Glu Thr Pro Ser 
    50                  55                  60                  


Ser Ala Asn Gly Pro Ser Arg Glu Gly Ser Arg Leu Pro Pro Ala Arg 
65                  70                  75                  80  


Glu Gly His Pro Val Tyr Pro Gln Leu Arg Pro Gly Tyr Ile Pro Ile 
                85                  90                  95      


Pro Val Leu His Glu Gly Ala Glu Asn Arg Gln Val His Pro Phe His 
            100                 105                 110         


Val Tyr Pro Gln Pro Gly Met Gln Arg Phe Arg Thr Glu Ala Ala Ala 
        115                 120                 125             


Ala Ala Pro Gln Arg Ser Gln Ser Pro Leu Arg Gly Met Pro Glu Thr 
    130                 135                 140                 


Thr Gln Pro Asp Lys Gln Cys Gly Gln Val Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Gln Pro Pro Ala Ser His Gly Pro Glu Arg Ser Gln Ser Pro Ala Ala 
                165                 170                 175     


Ser Asp Cys Ser Ser Ser Ser Ser Ser Ala Ser Leu Pro Ser Ser Gly 
            180                 185                 190         


Arg Ser Ser Leu Gly Ser His Gln Leu Pro Arg Gly Tyr Ile Ser Ile 
        195                 200                 205             


Pro Val Ile His Glu Gln Asn Val Thr Arg Pro Ala Ala Gln Pro Ser 
    210                 215                 220                 


Phe His Gln Ala Gln Lys Thr His Tyr Pro Ala Gln Gln Gly Glu Tyr 
225                 230                 235                 240 


Gln Thr His Gln Pro Val Tyr His Lys Ile Gln Gly Asp Asp Trp Glu 
                245                 250                 255     


Pro Arg Pro Leu Arg Ala Ala Ser Pro Phe Arg Ser Ser Val Gln Gly 
            260                 265                 270         


Ala Ser Ser Arg Glu Gly Ser Pro Ala Arg Ser Ser Thr Pro Leu His 
        275                 280                 285             


Ser Pro Ser Pro Ile Arg Val His Thr Val Val Asp Arg Pro Gln Gln 
    290                 295                 300                 


Pro Met Thr His Arg Glu Thr Ala Pro Val Ser Gln Pro Glu Asn Lys 
305                 310                 315                 320 


Pro Glu Ser Lys Pro Gly Pro Val Gly Pro Glu Leu Pro Pro Gly His 
                325                 330                 335     


Ile Pro Ile Gln Val Ile Arg Lys Glu Val Asp Ser Lys Pro Val Ser 
            340                 345                 350         


Gln Lys Pro Pro Pro Pro Ser Glu Lys Val Glu Val Lys Val Pro Pro 
        355                 360                 365             


Ala Pro Val Pro Cys Pro Pro Pro Ser Pro Gly Pro Ser Ala Val Pro 
    370                 375                 380                 


Ser Ser Pro Lys Ser Val Ala Thr Glu Glu Arg Ala Ala Pro Ser Thr 
385                 390                 395                 400 


Ala Pro Ala Glu Ala Thr Pro Pro Lys Pro Gly Glu Ala Glu Ala Pro 
                405                 410                 415     


Pro Lys His Pro Gly Val Leu Lys Val Glu Ala Ile Leu Glu Lys Val 
            420                 425                 430         


Gln Gly Leu Glu Gln Ala Val Asp Asn Phe Glu Gly Lys Lys Thr Asp 
        435                 440                 445             


Lys Lys Tyr Leu Met Ile Glu Glu Tyr Leu Thr Lys Glu Leu Leu Ala 
    450                 455                 460                 


Leu Asp Ser Val Asp Pro Glu Gly Arg Ala Asp Val Arg Gln Ala Arg 
465                 470                 475                 480 


Arg Asp Gly Val Arg Lys Val Gln Thr Ile Leu Glu Lys Leu Glu Gln 
                485                 490                 495     


Lys Ala Ile Asp Val Pro Gly Gln Val Gln Val Tyr Glu Leu Gln Pro 
            500                 505                 510         


Ser Asn Leu Glu Ala Asp Gln Pro Leu Gln Ala Ile Met Glu Met Gly 
        515                 520                 525             


Ala Val Ala Ala Asp Lys Gly Lys Lys Asn Ala Gly Asn Ala Glu Asp 
    530                 535                 540                 


Pro His Thr Glu Thr Gln Gln Pro Glu Ala Thr Ala Ala Ala Thr Ser 
545                 550                 555                 560 


Asn Pro Ser Ser Met Thr Asp Thr Pro Gly Asn Pro Ala Ala Pro 
                565                 570                 575 


<210>  1044
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAG4__Homo_sapiens__NP_001191807

<400>  1044

Met Ser Ala Leu Arg Arg Ser Gly Tyr Gly Pro Ser Asp Gly Pro Ser 
1               5                   10                  15      


Tyr Gly Arg Tyr Tyr Gly Pro Gly Gly Gly Asp Val Pro Val His Pro 
            20                  25                  30          


Pro Pro Pro Leu Tyr Pro Leu Arg Pro Glu Pro Pro Gln Pro Pro Ile 
        35                  40                  45              


Ser Trp Arg Val Arg Gly Gly Gly Pro Ala Glu Thr Thr Trp Leu Gly 
    50                  55                  60                  


Glu Gly Gly Gly Gly Asp Gly Tyr Tyr Pro Ser Gly Gly Ala Trp Pro 
65                  70                  75                  80  


Glu Pro Gly Arg Ala Gly Gly Ser His Gln Ser Leu Asn Ser Tyr Thr 
                85                  90                  95      


Asn Gly Ala Tyr Gly Pro Thr Tyr Pro Pro Gly Pro Gly Ala Asn Thr 
            100                 105                 110         


Ala Ser Tyr Ser Gly Ala Tyr Tyr Ala Pro Gly Tyr Thr Gln Thr Ser 
        115                 120                 125             


Tyr Ser Thr Glu Val Pro Ser Thr Tyr Arg Ser Ser Gly Asn Ser Pro 
    130                 135                 140                 


Thr Pro Val Ser Arg Trp Ile Tyr Pro Gln Gln Asp Cys Gln Thr Glu 
145                 150                 155                 160 


Ala Pro Pro Leu Arg Gly Gln Val Pro Gly Tyr Pro Pro Ser Gln Asn 
                165                 170                 175     


Pro Gly Met Thr Leu Pro His Tyr Pro Tyr Gly Asp Gly Asn Arg Ser 
            180                 185                 190         


Val Pro Gln Ser Gly Pro Thr Val Arg Pro Gln Glu Asp Ala Trp Ala 
        195                 200                 205             


Ser Pro Gly Ala Tyr Gly Met Gly Gly Arg Tyr Pro Trp Pro Ser Ser 
    210                 215                 220                 


Ala Pro Ser Ala Pro Pro Gly Asn Leu Tyr Met Thr Glu Ser Thr Ser 
225                 230                 235                 240 


Pro Trp Pro Ser Ser Gly Ser Pro Gln Ser Pro Pro Ser Pro Pro Val 
                245                 250                 255     


Gln Gln Pro Lys Asp Ser Ser Tyr Pro Tyr Ser Gln Ser Asp Gln Ser 
            260                 265                 270         


Met Asn Arg His Asn Phe Pro Cys Ser Val His Gln Tyr Glu Ser Ser 
        275                 280                 285             


Gly Thr Val Asn Asn Asp Asp Ser Asp Leu Leu Asp Ser Gln Val Gln 
    290                 295                 300                 


Tyr Ser Ala Glu Pro Gln Leu Tyr Gly Asn Ala Thr Ser Asp His Pro 
305                 310                 315                 320 


Asn Asn Gln Asp Gln Ser Ser Ser Leu Pro Glu Glu Cys Val Pro Ser 
                325                 330                 335     


Asp Glu Ser Thr Pro Pro Ser Ile Lys Lys Ile Ile His Val Leu Glu 
            340                 345                 350         


Lys Val Gln Tyr Leu Glu Gln Glu Val Glu Glu Phe Val Gly Lys Lys 
        355                 360                 365             


Thr Asp Lys Ala Tyr Trp Leu Leu Glu Glu Met Leu Thr Lys Glu Leu 
    370                 375                 380                 


Leu Glu Leu Asp Ser Val Glu Thr Gly Gly Gln Asp Ser Val Arg Gln 
385                 390                 395                 400 


Ala Arg Lys Glu Ala Val Cys Lys Ile Gln Ala Ile Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Lys Gly Leu 
            420     


<210>  1045
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAG5__Homo_sapiens__NP_001015049

<400>  1045

Met Arg Phe His Trp Leu Pro Thr Leu Ser Glu Pro Phe Asp Arg Asn 
1               5                   10                  15      


Gln Glu Leu Glu Thr Cys Ile Arg Pro Leu Trp Thr Pro Ser Gly Ser 
            20                  25                  30          


Ala Cys Glu Thr Glu His Asn Lys Ser Met Asp Met Gly Asn Gln His 
        35                  40                  45              


Pro Ser Ile Ser Arg Leu Gln Glu Ile Gln Lys Glu Val Lys Ser Val 
    50                  55                  60                  


Glu Gln Gln Val Ile Gly Phe Ser Gly Leu Ser Asp Asp Lys Asn Tyr 
65                  70                  75                  80  


Lys Lys Leu Glu Arg Ile Leu Thr Lys Gln Leu Phe Glu Ile Asp Ser 
                85                  90                  95      


Val Asp Thr Glu Gly Lys Gly Asp Ile Gln Gln Ala Arg Lys Arg Ala 
            100                 105                 110         


Ala Gln Glu Thr Glu Arg Leu Leu Lys Glu Leu Glu Gln Asn Ala Asn 
        115                 120                 125             


His Pro His Arg Ile Glu Ile Gln Asn Ile Phe Glu Glu Ala Gln Ser 
    130                 135                 140                 


Leu Val Arg Glu Lys Ile Val Pro Phe Tyr Asn Gly Gly Asn Cys Val 
145                 150                 155                 160 


Thr Asp Glu Phe Glu Glu Gly Ile Gln Asp Ile Ile Leu Arg Leu Thr 
                165                 170                 175     


His Val Lys Thr Gly Gly Lys Ile Ser Leu Arg Lys Ala Arg Tyr His 
            180                 185                 190         


Thr Leu Thr Lys Ile Cys Ala Val Gln Glu Ile Ile Glu Asp Cys Met 
        195                 200                 205             


Lys Lys Gln Pro Ser Leu Pro Leu Ser Glu Asp Ala His Pro Ser Val 
    210                 215                 220                 


Ala Lys Ile Asn Phe Val Met Cys Glu Val Asn Lys Ala Arg Gly Val 
225                 230                 235                 240 


Leu Ile Ala Leu Leu Met Gly Val Asn Asn Asn Glu Thr Cys Arg His 
                245                 250                 255     


Leu Ser Cys Val Leu Ser Gly Leu Ile Ala Asp Leu Asp Ala Leu Asp 
            260                 265                 270         


Val Cys Gly Arg Thr Glu Ile Arg Asn Tyr Arg Arg Glu Val Val Glu 
        275                 280                 285             


Asp Ile Asn Lys Leu Leu Lys Tyr Leu Asp Leu Glu Glu Glu Ala Asp 
    290                 295                 300                 


Thr Thr Lys Ala Phe Asp Leu Arg Gln Asn His Ser Ile Leu Lys Ile 
305                 310                 315                 320 


Glu Lys Val Leu Lys Arg Met Arg Glu Ile Lys Asn Glu Leu Leu Gln 
                325                 330                 335     


Ala Gln Asn Pro Ser Glu Leu Tyr Leu Ser Ser Lys Thr Glu Leu Gln 
            340                 345                 350         


Gly Leu Ile Gly Gln Leu Asp Glu Val Ser Leu Glu Lys Asn Pro Cys 
        355                 360                 365             


Ile Arg Glu Ala Arg Arg Arg Ala Val Ile Glu Val Gln Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Ile Asp Leu Lys Glu Ala Leu Glu Lys Arg Lys Leu Phe Ala 
385                 390                 395                 400 


Cys Glu Glu His Pro Ser His Lys Ala Val Trp Asn Val Leu Gly Asn 
                405                 410                 415     


Leu Ser Glu Ile Gln Gly Glu Val Leu Ser Phe Asp Gly Asn Arg Thr 
            420                 425                 430         


Asp Lys Asn Tyr Ile Arg Leu Glu Glu Leu Leu Thr Lys Gln Leu Leu 
        435                 440                 445             


Ala Leu Asp Ala Val Asp Pro Gln Gly Glu Glu Lys Cys Lys Ala Ala 
    450                 455                 460                 


Arg Lys Gln Ala Val Arg Leu Ala Gln Asn Ile Leu Ser Tyr Leu Asp 
465                 470                 475                 480 


Leu Lys Ser Asp Glu Trp Glu Tyr 
                485             


<210>  1046
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAG6__Homo_sapiens__NP_001186626

<400>  1046

Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser 
1               5                   10                  15      


Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile 
            20                  25                  30          


Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala 
        35                  40                  45              


Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg 
    50                  55                  60                  


Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys 
65                  70                  75                  80  


Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser 
                85                  90                  95      


Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly 
            100                 105                 110         


Ser Pro Pro Gly Thr Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn 
        115                 120                 125             


Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly 
    130                 135                 140                 


Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser 
145                 150                 155                 160 


Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile 
                165                 170                 175     


Gln Thr Leu Leu Ser Arg Met Glu Cys Arg Gly Gly Pro Gln Pro Gln 
            180                 185                 190         


His Ser Gln Pro Pro Pro Gln Pro Pro Ala Val Thr Pro Glu Pro Val 
        195                 200                 205             


Ala Leu Ser Ser Gln Thr Ser Glu Pro Val Glu Ser Glu Ala Pro Pro 
    210                 215                 220                 


Arg Glu Pro Met Glu Ala Glu Glu Val Glu Glu Arg Ala Pro Ala Gln 
225                 230                 235                 240 


Asn Pro Glu Leu Thr Pro Gly Pro Ala Pro Ala Gly Pro Thr Pro Ala 
                245                 250                 255     


Pro Glu Thr Asn Ala Pro Asn His Pro Ser Pro Ala Glu Tyr Val Glu 
            260                 265                 270         


Val Leu Gln Glu Leu Gln Arg Leu Glu Ser Arg Leu Gln Pro Phe Leu 
        275                 280                 285             


Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala Ala Thr Thr Asp Tyr Asn 
    290                 295                 300                 


Asn Asn His Glu Gly Arg Glu Glu Asp Gln Arg Leu Ile Asn Leu Val 
305                 310                 315                 320 


Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr Phe Val Ala Leu Ser Asp 
                325                 330                 335     


Leu Arg Cys Asn Leu Ala Cys Thr Pro Pro Arg His Leu His Val Val 
            340                 345                 350         


Arg Pro Met Ser His Tyr Thr Thr Pro Met Val Leu Gln Gln Ala Ala 
        355                 360                 365             


Ile Pro Ile Gln Ile Asn Val Gly Thr Thr Val Thr Met Thr Gly Asn 
    370                 375                 380                 


Gly Thr Arg Pro Pro Pro Thr Pro Asn Ala Glu Ala Pro Pro Pro Gly 
385                 390                 395                 400 


Pro Gly Gln Ala Ser Ser Val Ala Pro Ser Ser Thr Asn Val Glu Ser 
                405                 410                 415     


Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro Ala Pro Pro Pro Ala Thr 
            420                 425                 430         


Ser His Pro Arg Val Ile Arg Ile Ser His Gln Ser Val Glu Pro Val 
        435                 440                 445             


Val Met Met His Met Asn Ile Gln Asp Ser Gly Thr Gln Pro Gly Gly 
    450                 455                 460                 


Val Pro Ser Ala Pro Thr Gly Pro Leu Gly Pro Pro Gly His Gly Gln 
465                 470                 475                 480 


Thr Leu Gly Gln Gln Val Pro Gly Phe Pro Thr Ala Pro Thr Arg Val 
                485                 490                 495     


Val Ile Ala Arg Pro Thr Pro Pro Gln Ala Arg Pro Ser His Pro Gly 
            500                 505                 510         


Gly Pro Pro Val Ser Gly Thr Leu Gly Ala Gly Leu Gly Thr Asn Ala 
        515                 520                 525             


Ser Leu Ala Gln Met Val Ser Gly Leu Val Gly Gln Leu Leu Met Gln 
    530                 535                 540                 


Pro Val Leu Val Ala Gln Gly Thr Pro Gly Ser Pro Gly Gly Leu Gly 
545                 550                 555                 560 


Leu Glu Ser Leu Ser Pro Glu Phe Phe Thr Ser Val Val Gln Gly Val 
                565                 570                 575     


Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala Gly Ser Ser Glu 
            580                 585                 590         


Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser Ser Asn Ile Phe 
        595                 600                 605             


Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly Ala Leu Leu Ser 
    610                 615                 620                 


Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val Met Leu Leu His 
625                 630                 635                 640 


Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln Leu Arg Ser Phe 
                645                 650                 655     


Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Thr Pro Ser Asn Ile 
            660                 665                 670         


Arg Met Ala Thr His Thr Leu Ile Thr Gly Leu Glu Glu Tyr Val Arg 
        675                 680                 685             


Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val Asp Ile Ile Arg 
    690                 695                 700                 


Thr Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser Ile Ala Ala His 
705                 710                 715                 720 


Val Leu His Cys Thr Asp Ser Gly Phe Gly Ala Arg Leu Leu Glu Leu 
                725                 730                 735     


Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn Leu His Cys Leu 
            740                 745                 750         


Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn Gly Arg Ile Arg 
        755                 760                 765             


Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser Trp Leu Thr Thr 
    770                 775                 780                 


Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His Met Pro Val Gly 
785                 790                 795                 800 


Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly Asp Pro Pro Gln 
                805                 810                 815     


Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala Glu Arg Ala Ser 
            820                 825                 830         


Pro Glu Pro Gln Glu Trp Val Pro Ile Ile Gln Gln Asp Ile Gln Ser 
        835                 840                 845             


Gln Arg Lys Val Lys Pro Gln Pro Pro Leu Ser Asp Ala Tyr Leu Ser 
    850                 855                 860                 


Gly Met Pro Ala Lys Arg Arg Lys Leu Arg Ser Asp Ile Gln Lys Arg 
865                 870                 875                 880 


Leu Gln Glu Asp Pro Asn Tyr Ser Pro Gln Arg Phe Pro Asn Ala Gln 
                885                 890                 895     


Arg Ala Phe Ala Asp Asp Pro 
            900             


<210>  1047
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAIAP2L1__Homo_sapiens__NP_061330

<400>  1047

Met Ser Arg Gly Pro Glu Glu Val Asn Arg Leu Thr Glu Ser Thr Tyr 
1               5                   10                  15      


Arg Asn Val Met Glu Gln Phe Asn Pro Gly Leu Arg Asn Leu Ile Asn 
            20                  25                  30          


Leu Gly Lys Asn Tyr Glu Lys Ala Val Asn Ala Met Ile Leu Ala Gly 
        35                  40                  45              


Lys Ala Tyr Tyr Asp Gly Val Ala Lys Ile Gly Glu Ile Ala Thr Gly 
    50                  55                  60                  


Ser Pro Val Ser Thr Glu Leu Gly His Val Leu Ile Glu Ile Ser Ser 
65                  70                  75                  80  


Thr His Lys Lys Leu Asn Glu Ser Leu Asp Glu Asn Phe Lys Lys Phe 
                85                  90                  95      


His Lys Glu Ile Ile His Glu Leu Glu Lys Lys Ile Glu Leu Asp Val 
            100                 105                 110         


Lys Tyr Met Asn Ala Thr Leu Lys Arg Tyr Gln Thr Glu His Lys Asn 
        115                 120                 125             


Lys Leu Glu Ser Leu Glu Lys Ser Gln Ala Glu Leu Lys Lys Ile Arg 
    130                 135                 140                 


Arg Lys Ser Gln Gly Ser Arg Asn Ala Leu Lys Tyr Glu His Lys Glu 
145                 150                 155                 160 


Ile Glu Tyr Val Glu Thr Val Thr Ser Arg Gln Ser Glu Ile Gln Lys 
                165                 170                 175     


Phe Ile Ala Asp Gly Cys Lys Glu Ala Leu Leu Glu Glu Lys Arg Arg 
            180                 185                 190         


Phe Cys Phe Leu Val Asp Lys His Cys Gly Phe Ala Asn His Ile His 
        195                 200                 205             


Tyr Tyr His Leu Gln Ser Ala Glu Leu Leu Asn Ser Lys Leu Pro Arg 
    210                 215                 220                 


Trp Gln Glu Thr Cys Val Asp Ala Ile Lys Val Pro Glu Lys Ile Met 
225                 230                 235                 240 


Asn Met Ile Glu Glu Ile Lys Thr Pro Ala Ser Thr Pro Val Ser Gly 
                245                 250                 255     


Thr Pro Gln Ala Ser Pro Met Ile Glu Arg Ser Asn Val Val Arg Lys 
            260                 265                 270         


Asp Tyr Asp Thr Leu Ser Lys Cys Ser Pro Lys Met Pro Pro Ala Pro 
        275                 280                 285             


Ser Gly Arg Ala Tyr Thr Ser Pro Leu Ile Asp Met Phe Asn Asn Pro 
    290                 295                 300                 


Ala Thr Ala Ala Pro Asn Ser Gln Arg Val Asn Asn Ser Thr Gly Thr 
305                 310                 315                 320 


Ser Glu Asp Pro Ser Leu Gln Arg Ser Val Ser Val Ala Thr Gly Leu 
                325                 330                 335     


Asn Met Met Lys Lys Gln Lys Val Lys Thr Ile Phe Pro His Thr Ala 
            340                 345                 350         


Gly Ser Asn Lys Thr Leu Leu Ser Phe Ala Gln Gly Asp Val Ile Thr 
        355                 360                 365             


Leu Leu Ile Pro Glu Glu Lys Asp Gly Trp Leu Tyr Gly Glu His Asp 
    370                 375                 380                 


Val Ser Lys Ala Arg Gly Trp Phe Pro Ser Ser Tyr Thr Lys Leu Leu 
385                 390                 395                 400 


Glu Glu Asn Glu Thr Glu Ala Val Thr Val Pro Thr Pro Ser Pro Thr 
                405                 410                 415     


Pro Val Arg Ser Ile Ser Thr Val Asn Leu Ser Glu Asn Ser Ser Val 
            420                 425                 430         


Val Ile Pro Pro Pro Asp Tyr Leu Glu Cys Leu Ser Met Gly Ala Ala 
        435                 440                 445             


Ala Asp Arg Arg Ala Asp Ser Ala Arg Thr Thr Ser Thr Phe Lys Ala 
    450                 455                 460                 


Pro Ala Ser Lys Pro Glu Thr Ala Ala Pro Asn Asp Ala Asn Gly Thr 
465                 470                 475                 480 


Ala Lys Pro Pro Phe Leu Ser Gly Glu Asn Pro Phe Ala Thr Val Lys 
                485                 490                 495     


Leu Arg Pro Thr Val Thr Asn Asp Arg Ser Ala Pro Ile Ile Arg 
            500                 505                 510     


<210>  1048
<211>  1116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAIAP3__Homo_sapiens__NP_001186025

<400>  1048

Met Ser Thr Leu Leu Asp Ile Lys Ser Ser Val Leu Arg Gln Val Gln 
1               5                   10                  15      


Val Cys Pro Ser Phe Arg Arg Arg Thr Glu Gln Asp Pro Gly Ser Ala 
            20                  25                  30          


Ser Ala Asp Pro Gln Glu Pro Ala Thr Gly Ala Trp Lys Pro Gly Asp 
        35                  40                  45              


Gly Val Glu Phe Phe Ala His Met Arg Leu Met Leu Lys Lys Gly Glu 
    50                  55                  60                  


Gly Arg Gln Gly Leu Pro Cys Leu Glu Val Pro Leu Arg Ser Gly Ser 
65                  70                  75                  80  


Pro Ala Pro Pro Glu Pro Val Asp Pro Ser Leu Gly Leu Arg Ala Leu 
                85                  90                  95      


Ala Pro Glu Glu Val Glu Met Leu Tyr Glu Glu Ala Leu Tyr Thr Val 
            100                 105                 110         


Leu Tyr Arg Ala Gly Thr Met Gly Pro Asp Gln Val Asp Asp Glu Glu 
        115                 120                 125             


Ala Leu Leu Ser Tyr Leu Gln Gln Val Phe Gly Thr Ser Leu Glu Glu 
    130                 135                 140                 


His Thr Glu Ala Ile Glu Arg Val Arg Lys Ala Lys Ala Pro Thr Tyr 
145                 150                 155                 160 


Ala Leu Lys Val Ser Val Met Arg Ala Lys Asn Leu Leu Ala Lys Asp 
                165                 170                 175     


Pro Asn Gly Phe Ser Asp Pro Tyr Cys Met Leu Gly Ile Leu Pro Ala 
            180                 185                 190         


Ser Asp Ala Thr Arg Glu Pro Arg Ala Gln Lys Glu Gln Arg Phe Gly 
        195                 200                 205             


Phe Arg Lys Gly Ser Lys Arg Gly Gly Pro Leu Pro Ala Lys Cys Ile 
    210                 215                 220                 


Gln Val Thr Glu Val Lys Ser Ser Thr Leu Asn Pro Val Trp Lys Glu 
225                 230                 235                 240 


His Phe Leu Phe Glu Ile Glu Asp Val Ser Thr Asp Gln Leu His Leu 
                245                 250                 255     


Asp Ile Trp Asp His Asp Asp Asp Val Ser Leu Val Glu Ala Cys Arg 
            260                 265                 270         


Lys Leu Asn Glu Val Ile Gly Leu Lys Gly Met Gly Arg Tyr Phe Lys 
        275                 280                 285             


Gln Ile Val Lys Ser Ala Arg Ala Asn Gly Thr Ala Gly Pro Thr Glu 
    290                 295                 300                 


Asp His Thr Asp Asp Phe Leu Gly Cys Leu Asn Ile Pro Val Arg Arg 
305                 310                 315                 320 


Asp Thr Ala Met Ser Gln Arg Gly Arg Ser Gly Phe Leu Ser His Leu 
                325                 330                 335     


Leu Leu Leu Ser His Leu Leu Arg Leu Glu His Ser Ala Glu Glu Pro 
            340                 345                 350         


Asn Ser Ser Ser Trp Arg Gly Glu Leu Ser Thr Pro Ala Ala Thr Ile 
        355                 360                 365             


Leu Cys Leu His Gly Ala Gln Ser Asn Leu Ser Pro Leu Gln Leu Ala 
    370                 375                 380                 


Val Leu His Trp Gln Val Ser Ser Arg His His Gln Thr Cys Thr Leu 
385                 390                 395                 400 


Asp Tyr Ser Tyr Leu Leu Gly Leu Leu Glu Asp Met Gln Ala His Trp 
                405                 410                 415     


Glu Glu Ala Pro Ser Leu Pro Gln Glu Gln Glu Glu Ser Leu Ala Asp 
            420                 425                 430         


Ser Leu Ser Ala Phe Ser Glu Phe Gly Leu Gln Leu Leu Arg Gln Leu 
        435                 440                 445             


Arg Asp Tyr Phe Pro Ala Thr Asn Ser Thr Ala Val His Arg Leu Glu 
    450                 455                 460                 


Leu Leu Leu Lys Cys Leu Gly Lys Leu Gln Leu Phe Gln Pro Ser Phe 
465                 470                 475                 480 


Glu Ile Cys Pro Phe Glu Ser Glu Leu Asn Met Asp Ile Ala Ala Ala 
                485                 490                 495     


Leu Lys Arg Gly Asn Arg Glu Trp Tyr Asp Arg Ile Leu Asn Asp Lys 
            500                 505                 510         


Ser Pro Arg Glu Gln Pro Gly Pro Gln Arg Leu Pro Gly Leu Val Val 
        515                 520                 525             


Leu Ala Asp Ala Val Tyr Asp Asp Leu Gln Phe Cys Tyr Ser Val Tyr 
    530                 535                 540                 


Ala Ser Leu Phe His Ser Ile Leu Asn Val Asp Val Phe Thr Leu Thr 
545                 550                 555                 560 


Phe Arg Gln Leu Glu Arg Leu Val Ala Glu Glu Ala Trp Val Leu Thr 
                565                 570                 575     


Glu Glu Leu Ser Pro Lys Met Thr Leu Glu Val Ala Ser Gly Leu Phe 
            580                 585                 590         


Glu Leu Tyr Leu Thr Leu Ala Asp Leu Gln Arg Phe Trp Asp Ser Ile 
        595                 600                 605             


Pro Gly Arg Asp Ser Arg Ser Leu Ala Leu Ala Gly Ile His Ala Pro 
    610                 615                 620                 


Phe Leu Pro Ala Val Lys Leu Trp Phe Gln Val Leu Arg Asp Gln Ala 
625                 630                 635                 640 


Lys Trp Arg Leu Gln Gly Ala Val Asp Met Asp Thr Leu Glu Pro Val 
                645                 650                 655     


Asp Ala Ser Ser Arg His Ser Ser Ser Ala Ala Thr Ala Gly Leu Cys 
            660                 665                 670         


Leu Ser His Ile Gln Glu Leu Trp Val Arg Leu Ala Trp Pro Asp Pro 
        675                 680                 685             


Ala Gln Ala Gln Gly Leu Gly Thr Gln Leu Gly Gln Asp Val Cys Glu 
    690                 695                 700                 


Ala Thr Leu Phe Tyr Thr Glu Leu Leu Arg Lys Lys Val Asp Thr Gln 
705                 710                 715                 720 


Pro Gly Ala Ala Gly Glu Ala Val Ser Glu Ala Leu Cys Val Val Leu 
                725                 730                 735     


Asn Asn Val Glu Leu Val Arg Lys Ala Ala Gly Gln Ala Leu Lys Gly 
            740                 745                 750         


Leu Ala Trp Pro Glu Gly Ala Thr Gly Pro Glu Gly Val Leu Pro Arg 
        755                 760                 765             


Pro Leu Leu Ser Cys Thr Gln Ala Leu Asp Asp Asp Leu Gln Arg Glu 
    770                 775                 780                 


Ala His Thr Val Thr Ala His Leu Thr Ser Lys Met Val Gly Asp Ile 
785                 790                 795                 800 


Arg Lys Tyr Val Gln His Ile Ser Leu Ser Pro Asp Ser Ile Gln Asn 
                805                 810                 815     


Asp Glu Ala Val Ala Pro Leu Met Lys Tyr Leu Asp Glu Lys Leu Ala 
            820                 825                 830         


Leu Leu Asn Ala Ser Leu Val Lys Gly Asn Leu Ser Arg Val Leu Glu 
        835                 840                 845             


Ala Leu Trp Glu Leu Leu Leu Gln Ala Ile Leu Gln Ala Leu Gly Ala 
    850                 855                 860                 


Asn Arg Asp Val Ser Ala Asp Phe Tyr Ser Arg Phe His Phe Thr Leu 
865                 870                 875                 880 


Glu Ala Leu Val Ser Phe Phe His Ala Glu Gly Gln Gly Leu Pro Leu 
                885                 890                 895     


Glu Ser Leu Arg Asp Gly Ser Tyr Lys Arg Leu Lys Glu Glu Leu Arg 
            900                 905                 910         


Leu His Lys Cys Ser Thr Arg Glu Cys Ile Glu Gln Phe Tyr Leu Asp 
        915                 920                 925             


Lys Leu Lys Gln Arg Thr Leu Glu Gln Asn Arg Phe Gly Arg Leu Ser 
    930                 935                 940                 


Val Arg Cys His Tyr Glu Ala Ala Glu Gln Arg Leu Ala Val Glu Val 
945                 950                 955                 960 


Leu His Ala Ala Asp Leu Leu Pro Leu Asp Ala Asn Gly Leu Ser Asp 
                965                 970                 975     


Pro Phe Val Ile Val Glu Leu Gly Pro Pro His Leu Phe Pro Leu Val 
            980                 985                 990         


Arg Ser Gln Arg Thr Gln Val Lys  Thr Arg Thr Leu His  Pro Val Tyr 
        995                 1000                 1005             


Asp Glu  Leu Phe Tyr Phe Ser  Val Pro Ala Glu Ala  Cys Arg Arg 
    1010                 1015                 1020             


Arg Ala  Ala Cys Val Leu Phe  Thr Val Met Asp His  Asp Trp Leu 
    1025                 1030                 1035             


Ser Thr  Asn Asp Phe Ala Gly  Glu Ala Ala Leu Gly  Leu Gly Gly 
    1040                 1045                 1050             


Val Thr  Gly Val Ala Arg Pro  Gln Val Gly Gly Gly  Ala Arg Ala 
    1055                 1060                 1065             


Gly Gln  Pro Val Thr Leu His  Leu Cys Arg Pro Arg  Ala Gln Val 
    1070                 1075                 1080             


Arg Ser  Ala Leu Arg Arg Leu  Glu Gly Arg Thr Ser  Lys Glu Ala 
    1085                 1090                 1095             


Gln Glu  Phe Val Lys Lys Leu  Lys Glu Leu Glu Lys  Cys Met Glu 
    1100                 1105                 1110             


Ala Asp  Pro 
    1115     


<210>  1049
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAK1__Homo_sapiens__NP_001179

<400>  1049

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210>  1050
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAMBI__Homo_sapiens__NP_036474

<400>  1050

Met Asp Arg His Ser Ser Tyr Ile Phe Ile Trp Leu Gln Leu Glu Leu 
1               5                   10                  15      


Cys Ala Met Ala Val Leu Leu Thr Lys Gly Glu Ile Arg Cys Tyr Cys 
            20                  25                  30          


Asp Ala Ala His Cys Val Ala Thr Gly Tyr Met Cys Lys Ser Glu Leu 
        35                  40                  45              


Ser Ala Cys Phe Ser Arg Leu Leu Asp Pro Gln Asn Ser Asn Ser Pro 
    50                  55                  60                  


Leu Thr His Gly Cys Leu Asp Ser Leu Ala Ser Thr Thr Asp Ile Cys 
65                  70                  75                  80  


Gln Ala Lys Gln Ala Arg Asn His Ser Gly Thr Thr Ile Pro Thr Leu 
                85                  90                  95      


Glu Cys Cys His Glu Asp Met Cys Asn Tyr Arg Gly Leu His Asp Val 
            100                 105                 110         


Leu Ser Pro Pro Arg Gly Glu Ala Ser Gly Gln Gly Asn Arg Tyr Gln 
        115                 120                 125             


His Asp Gly Ser Arg Asn Leu Ile Thr Lys Val Gln Glu Leu Thr Ser 
    130                 135                 140                 


Ser Lys Glu Leu Trp Phe Arg Ala Ala Val Ile Ala Val Pro Ile Ala 
145                 150                 155                 160 


Gly Gly Leu Ile Leu Val Leu Leu Ile Met Leu Ala Leu Arg Met Leu 
                165                 170                 175     


Arg Ser Glu Asn Lys Arg Leu Gln Asp Gln Arg Gln Gln Met Leu Ser 
            180                 185                 190         


Arg Leu His Tyr Ser Phe His Gly His His Ser Lys Lys Gly Gln Val 
        195                 200                 205             


Ala Lys Leu Asp Leu Glu Cys Met Val Pro Val Ser Gly His Glu Asn 
    210                 215                 220                 


Cys Cys Leu Thr Cys Asp Lys Met Arg Gln Ala Asp Leu Ser Asn Asp 
225                 230                 235                 240 


Lys Ile Leu Ser Leu Val His Trp Gly Met Tyr Ser Gly His Gly Lys 
                245                 250                 255     


Leu Glu Phe Val 
            260 


<210>  1051
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BANF1__Homo_sapiens__NP_001137457

<400>  1051

Met Thr Thr Ser Gln Lys His Arg Asp Phe Val Ala Glu Pro Met Gly 
1               5                   10                  15      


Glu Lys Pro Val Gly Ser Leu Ala Gly Ile Gly Glu Val Leu Gly Lys 
            20                  25                  30          


Lys Leu Glu Glu Arg Gly Phe Asp Lys Ala Tyr Val Val Leu Gly Gln 
        35                  40                  45              


Phe Leu Val Leu Lys Lys Asp Glu Asp Leu Phe Arg Glu Trp Leu Lys 
    50                  55                  60                  


Asp Thr Cys Gly Ala Asn Ala Lys Gln Ser Arg Asp Cys Phe Gly Cys 
65                  70                  75                  80  


Leu Arg Glu Trp Cys Asp Ala Phe Leu 
                85                  


<210>  1052
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BANK1__Homo_sapiens__NP_001077376

<400>  1052

Met Ile Tyr Glu Glu Asp Ala Glu Glu Trp Ala Leu Tyr Leu Thr Glu 
1               5                   10                  15      


Val Phe Leu His Val Val Lys Arg Glu Ala Ile Leu Leu Tyr Arg Leu 
            20                  25                  30          


Glu Asn Phe Ser Phe Arg His Leu Glu Leu Leu Asn Leu Thr Ser Tyr 
        35                  40                  45              


Lys Cys Lys Leu Leu Ile Leu Ser Asn Ser Leu Leu Arg Asp Leu Thr 
    50                  55                  60                  


Pro Lys Lys Cys Gln Phe Leu Glu Lys Ile Leu His Ser Pro Lys Ser 
65                  70                  75                  80  


Val Val Thr Leu Leu Cys Gly Val Lys Ser Ser Asp Gln Leu Tyr Glu 
                85                  90                  95      


Leu Leu Asn Ile Ser Gln Ser Arg Trp Glu Ile Ser Thr Glu Gln Glu 
            100                 105                 110         


Pro Glu Asp Tyr Ile Ser Val Ile Gln Ser Ile Ile Phe Lys Asp Ser 
        115                 120                 125             


Glu Asp Tyr Phe Glu Val Asn Ile Pro Thr Asp Leu Arg Ala Lys His 
    130                 135                 140                 


Ser Gly Glu Ile Ser Glu Arg Lys Glu Ile Glu Glu Leu Ser Glu Ala 
145                 150                 155                 160 


Ser Arg Asn Thr Ile Pro Leu Ala Val Val Leu Pro Thr Glu Ile Pro 
                165                 170                 175     


Cys Glu Asn Pro Gly Glu Ile Phe Ile Ile Leu Arg Asp Glu Val Ile 
            180                 185                 190         


Gly Asp Thr Val Glu Val Glu Phe Thr Ser Ser Asn Lys Arg Ile Arg 
        195                 200                 205             


Thr Arg Pro Ala Leu Trp Asn Lys Lys Val Trp Cys Met Lys Ala Leu 
    210                 215                 220                 


Glu Phe Pro Ala Gly Ser Val His Val Asn Val Tyr Cys Asp Gly Ile 
225                 230                 235                 240 


Val Lys Ala Thr Thr Lys Ile Lys Tyr Tyr Pro Thr Ala Lys Ala Lys 
                245                 250                 255     


Glu Cys Leu Phe Arg Met Ala Asp Ser Gly Glu Ser Leu Cys Gln Asn 
            260                 265                 270         


Ser Ile Glu Glu Leu Asp Gly Val Leu Thr Ser Ile Phe Lys His Glu 
        275                 280                 285             


Ile Pro Tyr Tyr Glu Phe Gln Ser Leu Gln Thr Glu Ile Cys Ser Gln 
    290                 295                 300                 


Asn Lys Tyr Thr His Phe Lys Glu Leu Pro Thr Leu Leu His Cys Ala 
305                 310                 315                 320 


Ala Lys Phe Gly Leu Lys Asn Leu Ala Ile His Leu Leu Gln Cys Ser 
                325                 330                 335     


Gly Ala Thr Trp Ala Ser Lys Met Lys Asn Met Glu Gly Ser Asp Pro 
            340                 345                 350         


Ala His Ile Ala Glu Arg His Gly His Lys Glu Leu Lys Lys Ile Phe 
        355                 360                 365             


Glu Asp Phe Ser Ile Gln Glu Ile Asp Ile Asn Asn Glu Gln Glu Asn 
    370                 375                 380                 


Asp Tyr Glu Glu Asp Ile Ala Ser Phe Ser Thr Tyr Ile Pro Ser Thr 
385                 390                 395                 400 


Gln Asn Pro Ala Phe His His Glu Ser Arg Lys Thr Tyr Gly Gln Ser 
                405                 410                 415     


Ala Asp Gly Ala Glu Ala Asn Glu Met Glu Gly Glu Gly Lys Gln Asn 
            420                 425                 430         


Gly Ser Gly Met Glu Thr Lys His Ser Pro Leu Glu Val Gly Ser Glu 
        435                 440                 445             


Ser Ser Glu Asp Gln Tyr Asp Asp Leu Tyr Val Phe Ile Pro Gly Ala 
    450                 455                 460                 


Asp Pro Glu Asn Asn Ser Gln Glu Pro Leu Met Ser Ser Arg Pro Pro 
465                 470                 475                 480 


Leu Pro Pro Pro Arg Pro Val Ala Asn Ala Phe Gln Leu Glu Arg Pro 
                485                 490                 495     


His Phe Thr Leu Pro Gly Thr Met Val Glu Gly Gln Met Glu Arg Ser 
            500                 505                 510         


Gln Asn Trp Gly His Pro Gly Val Arg Gln Glu Thr Gly Asp Glu Pro 
        515                 520                 525             


Lys Gly Glu Lys Glu Lys Lys Glu Glu Glu Lys Glu Gln Glu Glu Glu 
    530                 535                 540                 


Glu Asp Pro Tyr Thr Phe Ala Glu Ile Asp Asp Ser Glu Tyr Asp Met 
545                 550                 555                 560 


Ile Leu Ala Asn Leu Ser Ile Lys Lys Lys Thr Gly Ser Arg Ser Phe 
                565                 570                 575     


Ile Ile Asn Arg Pro Pro Ala Pro Thr Pro Arg Pro Thr Ser Ile Pro 
            580                 585                 590         


Pro Lys Glu Glu Thr Thr Pro Tyr Ile Ala Gln Val Phe Gln Gln Lys 
        595                 600                 605             


Thr Ala Arg Arg Gln Ser Asp Asp Asp Lys Phe Arg Gly Leu Pro Lys 
    610                 615                 620                 


Lys Gln Asp Arg Ala Arg Ile Glu Ser Pro Ala Phe Ser Thr Leu Arg 
625                 630                 635                 640 


Gly Cys Leu Thr Asp Gly Gln Glu Glu Leu Ile Leu Leu Gln Glu Lys 
                645                 650                 655     


Val Lys Asn Gly Lys Met Ser Met Asp Glu Ala Leu Glu Lys Phe Lys 
            660                 665                 670         


His Trp Gln Met Gly Lys Ser Gly Leu Glu Met Ile Gln Gln Glu Lys 
        675                 680                 685             


Leu Arg Gln Leu Arg Asp Cys Ile Ile Gly Lys Arg Pro Glu Glu Glu 
    690                 695                 700                 


Asn Val Tyr Asn Lys Leu Thr Ile Val His His Pro Gly Gly Lys Glu 
705                 710                 715                 720 


Thr Ala His Asn Glu Asn Lys Phe Tyr Asn Val His Phe Ser Asn Lys 
                725                 730                 735     


Leu Pro Ala Arg Pro Gln Val Glu Lys Glu Phe Gly Phe Cys Cys Lys 
            740                 745                 750         


Lys Asp His 
        755 


<210>  1053
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BANP__Homo_sapiens__NP_001167010

<400>  1053

Met Met Ser Glu His Asp Leu Ala Asp Val Val Gln Ile Ala Val Glu 
1               5                   10                  15      


Asp Leu Ser Pro Asp His Pro Val Val Leu Glu Asn His Val Val Thr 
            20                  25                  30          


Asp Glu Asp Glu Pro Ala Leu Lys Arg Gln Arg Leu Glu Ile Asn Cys 
        35                  40                  45              


Gln Asp Pro Ser Ile Lys Ser Phe Leu Tyr Ser Ile Asn Gln Thr Ile 
    50                  55                  60                  


Cys Leu Arg Leu Asp Ser Ile Glu Ala Lys Leu Gln Ala Leu Glu Ala 
65                  70                  75                  80  


Thr Cys Lys Ser Leu Glu Glu Lys Leu Asp Leu Val Thr Asn Lys Gln 
                85                  90                  95      


His Ser Pro Ile Gln Val Pro Met Val Ala Gly Ser Pro Leu Gly Ala 
            100                 105                 110         


Thr Gln Thr Cys Asn Lys Val Arg Cys Val Val Pro Gln Thr Thr Val 
        115                 120                 125             


Ile Leu Asn Asn Asp Arg Gln Asn Ala Ile Val Ala Lys Met Glu Asp 
    130                 135                 140                 


Pro Leu Ser Asn Arg Ala Pro Asp Ser Leu Glu Asn Val Ile Ser Asn 
145                 150                 155                 160 


Ala Val Pro Gly Arg Arg Gln Asn Thr Ile Val Val Lys Val Pro Gly 
                165                 170                 175     


Gln Glu Asp Ser His His Glu Asp Gly Glu Ser Gly Ser Glu Ala Ser 
            180                 185                 190         


Asp Ser Val Ser Ser Cys Gly Gln Ala Gly Ser Gln Ser Ile Gly Ser 
        195                 200                 205             


Asn Val Thr Leu Ile Thr Leu Asn Ser Glu Glu Asp Tyr Pro Asn Gly 
    210                 215                 220                 


Thr Trp Leu Gly Asp Glu Asn Asn Pro Glu Met Arg Val Arg Cys Ala 
225                 230                 235                 240 


Ile Ile Pro Ser Asp Met Leu His Ile Ser Thr Asn Cys Arg Thr Ala 
                245                 250                 255     


Glu Lys Met Ala Leu Thr Leu Leu Asp Tyr Leu Phe His Arg Glu Val 
            260                 265                 270         


Gln Ala Val Ser Asn Leu Ser Gly Gln Gly Lys His Gly Lys Lys Gln 
        275                 280                 285             


Leu Asp Pro Leu Thr Ile Tyr Gly Ile Arg Cys His Leu Phe Tyr Lys 
    290                 295                 300                 


Phe Gly Ile Thr Glu Ser Asp Trp Tyr Arg Ile Lys Gln Ser Ile Asp 
305                 310                 315                 320 


Ser Lys Cys Arg Thr Ala Trp Arg Arg Lys Gln Arg Gly Gln Ser Leu 
                325                 330                 335     


Ala Val Lys Ser Phe Ser Arg Arg Thr Pro Asn Ser Ser Ser Tyr Cys 
            340                 345                 350         


Pro Ser Glu Pro Met Met Ser Thr Pro Pro Pro Ala Ser Glu Leu Pro 
        355                 360                 365             


Gln Pro Gln Pro Gln Pro Gln Ala Leu His Tyr Ala Leu Ala Asn Ala 
    370                 375                 380                 


Gln Gln Val Gln Ile His Gln Ile Gly Glu Asp Gly Gln Val Gln Val 
385                 390                 395                 400 


Gly His Leu His Ile Ala Gln Val Pro Gln Gly Glu Gln Val Gln Ile 
                405                 410                 415     


Thr Gln Asp Ser Glu Gly Asn Leu Gln Ile His His Val Gly Gln Asp 
            420                 425                 430         


Gly Gln Val Leu Gln Gly Ala Gln Leu Ile Ala Val Ala Ser Ser Asp 
        435                 440                 445             


Pro Ala Ala Ala Gly Val Asp Gly Ser Pro Leu Gln Gly Ser Asp Ile 
    450                 455                 460                 


Gln Val Gln Tyr Val Gln Leu Ala Pro Val Ser Asp His Thr Ala Gly 
465                 470                 475                 480 


Ala Gln Thr Ala Glu Ala Leu Gln Pro Thr Leu Gln Pro Glu Met Gln 
                485                 490                 495     


Leu Glu His Gly Ala Ile Gln Ile Gln 
            500                 505 


<210>  1054
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAP1__Homo_sapiens__NP_004647

<400>  1054

Met Asn Lys Gly Trp Leu Glu Leu Glu Ser Asp Pro Gly Leu Phe Thr 
1               5                   10                  15      


Leu Leu Val Glu Asp Phe Gly Val Lys Gly Val Gln Val Glu Glu Ile 
            20                  25                  30          


Tyr Asp Leu Gln Ser Lys Cys Gln Gly Pro Val Tyr Gly Phe Ile Phe 
        35                  40                  45              


Leu Phe Lys Trp Ile Glu Glu Arg Arg Ser Arg Arg Lys Val Ser Thr 
    50                  55                  60                  


Leu Val Asp Asp Thr Ser Val Ile Asp Asp Asp Ile Val Asn Asn Met 
65                  70                  75                  80  


Phe Phe Ala His Gln Leu Ile Pro Asn Ser Cys Ala Thr His Ala Leu 
                85                  90                  95      


Leu Ser Val Leu Leu Asn Cys Ser Ser Val Asp Leu Gly Pro Thr Leu 
            100                 105                 110         


Ser Arg Met Lys Asp Phe Thr Lys Gly Phe Ser Pro Glu Ser Lys Gly 
        115                 120                 125             


Tyr Ala Ile Gly Asn Ala Pro Glu Leu Ala Lys Ala His Asn Ser His 
    130                 135                 140                 


Ala Arg Pro Glu Pro Arg His Leu Pro Glu Lys Gln Asn Gly Leu Ser 
145                 150                 155                 160 


Ala Val Arg Thr Met Glu Ala Phe His Phe Val Ser Tyr Val Pro Ile 
                165                 170                 175     


Thr Gly Arg Leu Phe Glu Leu Asp Gly Leu Lys Val Tyr Pro Ile Asp 
            180                 185                 190         


His Gly Pro Trp Gly Glu Asp Glu Glu Trp Thr Asp Lys Ala Arg Arg 
        195                 200                 205             


Val Ile Met Glu Arg Ile Gly Leu Ala Thr Ala Gly Glu Pro Tyr His 
    210                 215                 220                 


Asp Ile Arg Phe Asn Leu Met Ala Val Val Pro Asp Arg Arg Ile Lys 
225                 230                 235                 240 


Tyr Glu Ala Arg Leu His Val Leu Lys Val Asn Arg Gln Thr Val Leu 
                245                 250                 255     


Glu Ala Leu Gln Gln Leu Ile Arg Val Thr Gln Pro Glu Leu Ile Gln 
            260                 265                 270         


Thr His Lys Ser Gln Glu Ser Gln Leu Pro Glu Glu Ser Lys Ser Ala 
        275                 280                 285             


Ser Asn Lys Ser Pro Leu Val Leu Glu Ala Asn Arg Ala Pro Ala Ala 
    290                 295                 300                 


Ser Glu Gly Asn His Thr Asp Gly Ala Glu Glu Ala Ala Gly Ser Cys 
305                 310                 315                 320 


Ala Gln Ala Pro Ser His Ser Pro Pro Asn Lys Pro Lys Leu Val Val 
                325                 330                 335     


Lys Pro Pro Gly Ser Ser Leu Asn Gly Val His Pro Asn Pro Thr Pro 
            340                 345                 350         


Ile Val Gln Arg Leu Pro Ala Phe Leu Asp Asn His Asn Tyr Ala Lys 
        355                 360                 365             


Ser Pro Met Gln Glu Glu Glu Asp Leu Ala Ala Gly Val Gly Arg Ser 
    370                 375                 380                 


Arg Val Pro Val Arg Pro Pro Gln Gln Tyr Ser Asp Asp Glu Asp Asp 
385                 390                 395                 400 


Tyr Glu Asp Asp Glu Glu Asp Asp Val Gln Asn Thr Asn Ser Ala Leu 
                405                 410                 415     


Arg Tyr Lys Gly Lys Gly Thr Gly Lys Pro Gly Ala Leu Ser Gly Ser 
            420                 425                 430         


Ala Asp Gly Gln Leu Ser Val Leu Gln Pro Asn Thr Ile Asn Val Leu 
        435                 440                 445             


Ala Glu Lys Leu Lys Glu Ser Gln Lys Asp Leu Ser Ile Pro Leu Ser 
    450                 455                 460                 


Ile Lys Thr Ser Ser Gly Ala Gly Ser Pro Ala Val Ala Val Pro Thr 
465                 470                 475                 480 


His Ser Gln Pro Ser Pro Thr Pro Ser Asn Glu Ser Thr Asp Thr Ala 
                485                 490                 495     


Ser Glu Ile Gly Ser Ala Phe Asn Ser Pro Leu Arg Ser Pro Ile Arg 
            500                 505                 510         


Ser Ala Asn Pro Thr Arg Pro Ser Ser Pro Val Thr Ser His Ile Ser 
        515                 520                 525             


Lys Val Leu Phe Gly Glu Asp Asp Ser Leu Leu Arg Val Asp Cys Ile 
    530                 535                 540                 


Arg Tyr Asn Arg Ala Val Arg Asp Leu Gly Pro Val Ile Ser Thr Gly 
545                 550                 555                 560 


Leu Leu His Leu Ala Glu Asp Gly Val Leu Ser Pro Leu Ala Leu Thr 
                565                 570                 575     


Glu Gly Gly Lys Gly Ser Ser Pro Ser Ile Arg Pro Ile Gln Gly Ser 
            580                 585                 590         


Gln Gly Ser Ser Ser Pro Val Glu Lys Glu Val Val Glu Ala Thr Asp 
        595                 600                 605             


Ser Arg Glu Lys Thr Gly Met Val Arg Pro Gly Glu Pro Leu Ser Gly 
    610                 615                 620                 


Glu Lys Tyr Ser Pro Lys Glu Leu Leu Ala Leu Leu Lys Cys Val Glu 
625                 630                 635                 640 


Ala Glu Ile Ala Asn Tyr Glu Ala Cys Leu Lys Glu Glu Val Glu Lys 
                645                 650                 655     


Arg Lys Lys Phe Lys Ile Asp Asp Gln Arg Arg Thr His Asn Tyr Asp 
            660                 665                 670         


Glu Phe Ile Cys Thr Phe Ile Ser Met Leu Ala Gln Glu Gly Met Leu 
        675                 680                 685             


Ala Asn Leu Val Glu Gln Asn Ile Ser Val Arg Arg Arg Gln Gly Val 
    690                 695                 700                 


Ser Ile Gly Arg Leu His Lys Gln Arg Lys Pro Asp Arg Arg Lys Arg 
705                 710                 715                 720 


Ser Arg Pro Tyr Lys Ala Lys Arg Gln 
                725                 


<210>  1055
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BARD1__Homo_sapiens__NP_000456

<400>  1055

Met Pro Asp Asn Arg Gln Pro Arg Asn Arg Gln Pro Arg Ile Arg Ser 
1               5                   10                  15      


Gly Asn Glu Pro Arg Ser Ala Pro Ala Met Glu Pro Asp Gly Arg Gly 
            20                  25                  30          


Ala Trp Ala His Ser Arg Ala Ala Leu Asp Arg Leu Glu Lys Leu Leu 
        35                  40                  45              


Arg Cys Ser Arg Cys Thr Asn Ile Leu Arg Glu Pro Val Cys Leu Gly 
    50                  55                  60                  


Gly Cys Glu His Ile Phe Cys Ser Asn Cys Val Ser Asp Cys Ile Gly 
65                  70                  75                  80  


Thr Gly Cys Pro Val Cys Tyr Thr Pro Ala Trp Ile Gln Asp Leu Lys 
                85                  90                  95      


Ile Asn Arg Gln Leu Asp Ser Met Ile Gln Leu Cys Ser Lys Leu Arg 
            100                 105                 110         


Asn Leu Leu His Asp Asn Glu Leu Ser Asp Leu Lys Glu Asp Lys Pro 
        115                 120                 125             


Arg Lys Ser Leu Phe Asn Asp Ala Gly Asn Lys Lys Asn Ser Ile Lys 
    130                 135                 140                 


Met Trp Phe Ser Pro Arg Ser Lys Lys Val Arg Tyr Val Val Ser Lys 
145                 150                 155                 160 


Ala Ser Val Gln Thr Gln Pro Ala Ile Lys Lys Asp Ala Ser Ala Gln 
                165                 170                 175     


Gln Asp Ser Tyr Glu Phe Val Ser Pro Ser Pro Pro Ala Asp Val Ser 
            180                 185                 190         


Glu Arg Ala Lys Lys Ala Ser Ala Arg Ser Gly Lys Lys Gln Lys Lys 
        195                 200                 205             


Lys Thr Leu Ala Glu Ile Asn Gln Lys Trp Asn Leu Glu Ala Glu Lys 
    210                 215                 220                 


Glu Asp Gly Glu Phe Asp Ser Lys Glu Glu Ser Lys Gln Lys Leu Val 
225                 230                 235                 240 


Ser Phe Cys Ser Gln Pro Ser Val Ile Ser Ser Pro Gln Ile Asn Gly 
                245                 250                 255     


Glu Ile Asp Leu Leu Ala Ser Gly Ser Leu Thr Glu Ser Glu Cys Phe 
            260                 265                 270         


Gly Ser Leu Thr Glu Val Ser Leu Pro Leu Ala Glu Gln Ile Glu Ser 
        275                 280                 285             


Pro Asp Thr Lys Ser Arg Asn Glu Val Val Thr Pro Glu Lys Val Cys 
    290                 295                 300                 


Lys Asn Tyr Leu Thr Ser Lys Lys Ser Leu Pro Leu Glu Asn Asn Gly 
305                 310                 315                 320 


Lys Arg Gly His His Asn Arg Leu Ser Ser Pro Ile Ser Lys Arg Cys 
                325                 330                 335     


Arg Thr Ser Ile Leu Ser Thr Ser Gly Asp Phe Val Lys Gln Thr Val 
            340                 345                 350         


Pro Ser Glu Asn Ile Pro Leu Pro Glu Cys Ser Ser Pro Pro Ser Cys 
        355                 360                 365             


Lys Arg Lys Val Gly Gly Thr Ser Gly Arg Lys Asn Ser Asn Met Ser 
    370                 375                 380                 


Asp Glu Phe Ile Ser Leu Ser Pro Gly Thr Pro Pro Ser Thr Leu Ser 
385                 390                 395                 400 


Ser Ser Ser Tyr Arg Arg Val Met Ser Ser Pro Ser Ala Met Lys Leu 
                405                 410                 415     


Leu Pro Asn Met Ala Val Lys Arg Asn His Arg Gly Glu Thr Leu Leu 
            420                 425                 430         


His Ile Ala Ser Ile Lys Gly Asp Ile Pro Ser Val Glu Tyr Leu Leu 
        435                 440                 445             


Gln Asn Gly Ser Asp Pro Asn Val Lys Asp His Ala Gly Trp Thr Pro 
    450                 455                 460                 


Leu His Glu Ala Cys Asn His Gly His Leu Lys Val Val Glu Leu Leu 
465                 470                 475                 480 


Leu Gln His Lys Ala Leu Val Asn Thr Thr Gly Tyr Gln Asn Asp Ser 
                485                 490                 495     


Pro Leu His Asp Ala Ala Lys Asn Gly His Val Asp Ile Val Lys Leu 
            500                 505                 510         


Leu Leu Ser Tyr Gly Ala Ser Arg Asn Ala Val Asn Ile Phe Gly Leu 
        515                 520                 525             


Arg Pro Val Asp Tyr Thr Asp Asp Glu Ser Met Lys Ser Leu Leu Leu 
    530                 535                 540                 


Leu Pro Glu Lys Asn Glu Ser Ser Ser Ala Ser His Cys Ser Val Met 
545                 550                 555                 560 


Asn Thr Gly Gln Arg Arg Asp Gly Pro Leu Val Leu Ile Gly Ser Gly 
                565                 570                 575     


Leu Ser Ser Glu Gln Gln Lys Met Leu Ser Glu Leu Ala Val Ile Leu 
            580                 585                 590         


Lys Ala Lys Lys Tyr Thr Glu Phe Asp Ser Thr Val Thr His Val Val 
        595                 600                 605             


Val Pro Gly Asp Ala Val Gln Ser Thr Leu Lys Cys Met Leu Gly Ile 
    610                 615                 620                 


Leu Asn Gly Cys Trp Ile Leu Lys Phe Glu Trp Val Lys Ala Cys Leu 
625                 630                 635                 640 


Arg Arg Lys Val Cys Glu Gln Glu Glu Lys Tyr Glu Ile Pro Glu Gly 
                645                 650                 655     


Pro Arg Arg Ser Arg Leu Asn Arg Glu Gln Leu Leu Pro Lys Leu Phe 
            660                 665                 670         


Asp Gly Cys Tyr Phe Tyr Leu Trp Gly Thr Phe Lys His His Pro Lys 
        675                 680                 685             


Asp Asn Leu Ile Lys Leu Val Thr Ala Gly Gly Gly Gln Ile Leu Ser 
    690                 695                 700                 


Arg Lys Pro Lys Pro Asp Ser Asp Val Thr Gln Thr Ile Asn Thr Val 
705                 710                 715                 720 


Ala Tyr His Ala Arg Pro Asp Ser Asp Gln Arg Phe Cys Thr Gln Tyr 
                725                 730                 735     


Ile Ile Tyr Glu Asp Leu Cys Asn Tyr His Pro Glu Arg Val Arg Gln 
            740                 745                 750         


Gly Lys Val Trp Lys Ala Pro Ser Ser Trp Phe Ile Asp Cys Val Met 
        755                 760                 765             


Ser Phe Glu Leu Leu Pro Leu Asp Ser 
    770                 775         


<210>  1056
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BARHL1__Homo_sapiens__NP_064448

<400>  1056

Met Glu Gly Ser Asn Gly Phe Gly Ile Asp Ser Ile Leu Ser His Arg 
1               5                   10                  15      


Ala Gly Ser Pro Ala Leu Pro Lys Gly Asp Pro Leu Leu Gly Asp Cys 
            20                  25                  30          


Arg Ser Pro Leu Glu Leu Ser Pro Arg Ser Glu Ser Ser Ser Asp Cys 
        35                  40                  45              


Ser Ser Pro Ala Ser Pro Gly Arg Asp Cys Leu Glu Thr Gly Thr Pro 
    50                  55                  60                  


Arg Pro Gly Gly Ala Ser Gly Pro Gly Leu Asp Ser His Leu Gln Pro 
65                  70                  75                  80  


Gly Gln Leu Ser Ala Pro Ala Gln Ser Arg Thr Val Thr Ser Ser Phe 
                85                  90                  95      


Leu Ile Arg Asp Ile Leu Ala Asp Cys Lys Pro Leu Ala Ala Cys Ala 
            100                 105                 110         


Pro Tyr Ser Ser Ser Gly Gln Pro Ala Ala Pro Glu Pro Gly Gly Arg 
        115                 120                 125             


Leu Ala Ala Lys Ala Ala Glu Asp Phe Arg Asp Lys Leu Asp Lys Ser 
    130                 135                 140                 


Gly Ser Asn Ala Ser Ser Asp Ser Glu Tyr Lys Val Lys Glu Glu Gly 
145                 150                 155                 160 


Asp Arg Glu Ile Ser Ser Ser Arg Asp Ser Pro Pro Val Arg Leu Lys 
                165                 170                 175     


Lys Pro Arg Lys Ala Arg Thr Ala Phe Thr Asp His Gln Leu Ala Gln 
            180                 185                 190         


Leu Glu Arg Ser Phe Glu Arg Gln Lys Tyr Leu Ser Val Gln Asp Arg 
        195                 200                 205             


Met Glu Leu Ala Ala Ser Leu Asn Leu Thr Asp Thr Gln Val Lys Thr 
    210                 215                 220                 


Trp Tyr Gln Asn Arg Arg Thr Lys Trp Lys Arg Gln Thr Ala Val Gly 
225                 230                 235                 240 


Leu Glu Leu Leu Ala Glu Ala Gly Asn Tyr Ser Ala Leu Gln Arg Met 
                245                 250                 255     


Phe Pro Ser Pro Tyr Phe Tyr Pro Gln Ser Leu Val Ser Asn Leu Asp 
            260                 265                 270         


Pro Gly Ala Ala Leu Tyr Leu Tyr Arg Gly Pro Ser Ala Pro Pro Pro 
        275                 280                 285             


Ala Leu Gln Arg Pro Leu Val Pro Arg Ile Leu Ile His Gly Leu Gln 
    290                 295                 300                 


Gly Ala Ser Glu Pro Pro Pro Pro Leu Pro Pro Leu Ala Gly Val Leu 
305                 310                 315                 320 


Pro Arg Ala Ala Gln Pro Arg 
                325         


<210>  1057
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BARX1__Homo_sapiens__NP_067545

<400>  1057

Met Gln Arg Pro Gly Glu Pro Gly Ala Ala Arg Phe Gly Pro Pro Glu 
1               5                   10                  15      


Gly Cys Ala Asp His Arg Pro His Arg Tyr Arg Ser Phe Met Ile Glu 
            20                  25                  30          


Glu Ile Leu Thr Glu Pro Pro Gly Pro Lys Gly Ala Ala Pro Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Gly Glu Leu Leu Lys Phe Gly Val Gln Ala Leu 
    50                  55                  60                  


Leu Ala Ala Arg Pro Phe His Ser His Leu Ala Val Leu Lys Ala Glu 
65                  70                  75                  80  


Gln Ala Ala Val Phe Lys Phe Pro Leu Ala Pro Leu Gly Cys Ser Gly 
                85                  90                  95      


Leu Ser Ser Ala Leu Leu Ala Ala Gly Pro Gly Leu Pro Gly Ala Ala 
            100                 105                 110         


Gly Ala Pro His Leu Pro Leu Glu Leu Gln Leu Arg Gly Lys Leu Glu 
        115                 120                 125             


Ala Ala Gly Pro Gly Glu Pro Gly Thr Lys Ala Lys Lys Gly Arg Arg 
    130                 135                 140                 


Ser Arg Thr Val Phe Thr Glu Leu Gln Leu Met Gly Leu Glu Lys Arg 
145                 150                 155                 160 


Phe Glu Lys Gln Lys Tyr Leu Ser Thr Pro Asp Arg Ile Asp Leu Ala 
                165                 170                 175     


Glu Ser Leu Gly Leu Ser Gln Leu Gln Val Lys Thr Trp Tyr Gln Asn 
            180                 185                 190         


Arg Arg Met Lys Trp Lys Lys Ile Val Leu Gln Gly Gly Gly Leu Glu 
        195                 200                 205             


Ser Pro Thr Lys Pro Lys Gly Arg Pro Lys Lys Asn Ser Ile Pro Thr 
    210                 215                 220                 


Ser Glu Gln Leu Thr Glu Gln Glu Arg Ala Lys Asp Ala Glu Lys Pro 
225                 230                 235                 240 


Ala Glu Val Pro Gly Glu Pro Ser Asp Arg Ser Arg Glu Asp 
                245                 250                 


<210>  1058
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BARX2__Homo_sapiens__NP_003649

<400>  1058

Met His Cys His Ala Glu Leu Arg Leu Ser Ser Pro Gly Gln Leu Lys 
1               5                   10                  15      


Ala Ala Arg Arg Arg Tyr Lys Thr Phe Met Ile Asp Glu Ile Leu Ser 
            20                  25                  30          


Lys Glu Thr Cys Asp Tyr Phe Glu Lys Leu Ser Leu Tyr Ser Val Cys 
        35                  40                  45              


Pro Ser Leu Val Val Arg Pro Lys Pro Leu His Ser Cys Thr Gly Ser 
    50                  55                  60                  


Pro Ser Leu Arg Ala Tyr Pro Leu Leu Ser Val Ile Thr Arg Gln Pro 
65                  70                  75                  80  


Thr Val Ile Ser His Leu Val Pro Ala Thr Pro Gly Ile Ala Gln Ala 
                85                  90                  95      


Leu Ser Cys His Gln Val Thr Glu Ala Val Ser Ala Glu Ala Pro Gly 
            100                 105                 110         


Gly Glu Ala Leu Ala Ser Ser Glu Ser Glu Thr Glu Gln Pro Thr Pro 
        115                 120                 125             


Arg Gln Lys Lys Pro Arg Arg Ser Arg Thr Ile Phe Thr Glu Leu Gln 
    130                 135                 140                 


Leu Met Gly Leu Glu Lys Lys Phe Gln Lys Gln Lys Tyr Leu Ser Thr 
145                 150                 155                 160 


Pro Asp Arg Leu Asp Leu Ala Gln Ser Leu Gly Leu Thr Gln Leu Gln 
                165                 170                 175     


Val Lys Thr Trp Tyr Gln Asn Arg Arg Met Lys Trp Lys Lys Met Val 
            180                 185                 190         


Leu Lys Gly Gly Gln Glu Ala Pro Thr Lys Pro Lys Gly Arg Pro Lys 
        195                 200                 205             


Lys Asn Ser Ile Pro Thr Ser Glu Glu Ile Glu Ala Glu Glu Lys Met 
    210                 215                 220                 


Asn Ser Gln Ala Gln Gly Gln Glu Gln Leu Glu Pro Ser Gln Gly Gln 
225                 230                 235                 240 


Glu Glu Leu Cys Glu Ala Gln Glu Pro Lys Ala Arg Asp Val Pro Leu 
                245                 250                 255     


Glu Met Ala Glu Pro Pro Asp Pro Pro Gln Glu Leu Pro Ile Pro Ser 
            260                 265                 270         


Ser Glu Pro Pro Pro Leu Ser 
        275                 


<210>  1059
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BASP1__Homo_sapiens__NP_006308

<400>  1059

Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      


Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Thr Glu 
            20                  25                  30          


Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Glu Pro 
        35                  40                  45              


Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly 
    50                  55                  60                  


Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu 
65                  70                  75                  80  


Glu Ala Pro Lys Ala Glu Pro Glu Lys Thr Glu Gly Ala Ala Glu Ala 
                85                  90                  95      


Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly 
            100                 105                 110         


Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Ala 
        115                 120                 125             


Pro Ala Glu Ser Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu 
    130                 135                 140                 


Glu Gly Glu Pro Lys Lys Thr Glu Ala Pro Ala Ala Pro Ala Ala Gln 
145                 150                 155                 160 


Glu Thr Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser 
                165                 170                 175     


Ser Glu Ala Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Thr Glu Ala 
            180                 185                 190         


Pro Ser Ser Thr Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu 
        195                 200                 205             


Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Thr Val Thr 
    210                 215                 220                 


Val Lys Glu 
225         


<210>  1060
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BATF2__Homo_sapiens__NP_612465

<400>  1060

Met His Leu Cys Gly Gly Asn Gly Leu Leu Thr Gln Thr Asp Pro Lys 
1               5                   10                  15      


Glu Gln Gln Arg Gln Leu Lys Lys Gln Lys Asn Arg Ala Ala Ala Gln 
            20                  25                  30          


Arg Ser Arg Gln Lys His Thr Asp Lys Ala Asp Ala Leu His Gln Gln 
        35                  40                  45              


His Glu Ser Leu Glu Lys Asp Asn Leu Ala Leu Arg Lys Glu Ile Gln 
    50                  55                  60                  


Ser Leu Gln Ala Glu Leu Ala Trp Trp Ser Arg Thr Leu His Val His 
65                  70                  75                  80  


Glu Arg Leu Cys Pro Met Asp Cys Ala Ser Cys Ser Ala Pro Gly Leu 
                85                  90                  95      


Leu Gly Cys Trp Asp Gln Ala Glu Gly Leu Leu Gly Pro Gly Pro Gln 
            100                 105                 110         


Gly Gln His Gly Cys Arg Glu Gln Leu Glu Leu Phe Gln Thr Pro Gly 
        115                 120                 125             


Ser Cys Tyr Pro Ala Gln Pro Leu Ser Pro Gly Pro Gln Pro His Asp 
    130                 135                 140                 


Ser Pro Ser Leu Leu Gln Cys Pro Leu Pro Ser Leu Ser Leu Gly Pro 
145                 150                 155                 160 


Ala Val Val Ala Glu Pro Pro Val Gln Leu Ser Pro Ser Pro Leu Leu 
                165                 170                 175     


Phe Ala Ser His Thr Gly Ser Ser Leu Gln Gly Ser Ser Ser Lys Leu 
            180                 185                 190         


Ser Ala Leu Gln Pro Ser Leu Thr Ala Gln Thr Ala Pro Pro Gln Pro 
        195                 200                 205             


Leu Glu Leu Glu His Pro Thr Arg Gly Lys Leu Gly Ser Ser Pro Asp 
    210                 215                 220                 


Asn Pro Ser Ser Ala Leu Gly Leu Ala Arg Leu Gln Ser Arg Glu His 
225                 230                 235                 240 


Lys Pro Ala Leu Ser Ala Ala Thr Trp Gln Gly Leu Val Val Asp Pro 
                245                 250                 255     


Ser Pro His Pro Leu Leu Ala Phe Pro Leu Leu Ser Ser Ala Gln Val 
            260                 265                 270         


His Phe 
        


<210>  1061
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BATF__Homo_sapiens__NP_006390

<400>  1061

Met Pro His Ser Ser Asp Ser Ser Asp Ser Ser Phe Ser Arg Ser Pro 
1               5                   10                  15      


Pro Pro Gly Lys Gln Asp Ser Ser Asp Asp Val Arg Arg Val Gln Arg 
            20                  25                  30          


Arg Glu Lys Asn Arg Ile Ala Ala Gln Lys Ser Arg Gln Arg Gln Thr 
        35                  40                  45              


Gln Lys Ala Asp Thr Leu His Leu Glu Ser Glu Asp Leu Glu Lys Gln 
    50                  55                  60                  


Asn Ala Ala Leu Arg Lys Glu Ile Lys Gln Leu Thr Glu Glu Leu Lys 
65                  70                  75                  80  


Tyr Phe Thr Ser Val Leu Asn Ser His Glu Pro Leu Cys Ser Val Leu 
                85                  90                  95      


Ala Ala Ser Thr Pro Ser Pro Pro Glu Val Val Tyr Ser Ala His Ala 
            100                 105                 110         


Phe His Gln Pro His Val Ser Ser Pro Arg Phe Gln Pro 
        115                 120                 125 


<210>  1062
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAX__Homo_sapiens__NP_001278357

<400>  1062

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Gly Leu 
145                 150                 155                 160 


Pro Leu Ala Glu Ser Leu Lys Arg Leu Met Ser Leu Ser Pro Gly Arg 
                165                 170                 175     


Pro Pro Leu Leu Leu Trp Asp Ala His Val Ala Asp Arg Asp His Leu 
            180                 185                 190         


Cys Gly Gly Ser Ala His Arg Leu Thr His His Leu Glu Glu Asp Gly 
        195                 200                 205             


Leu Arg Pro Pro Ala Ala Leu Asp Cys Val Phe Pro Pro 
    210                 215                 220     


<210>  1063
<211>  1556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAZ1A__Homo_sapiens__NP_038476

<400>  1063

Met Pro Leu Leu His Arg Lys Pro Phe Val Arg Gln Lys Pro Pro Ala 
1               5                   10                  15      


Asp Leu Arg Pro Asp Glu Glu Val Phe Tyr Cys Lys Val Thr Asn Glu 
            20                  25                  30          


Ile Phe Arg His Tyr Asp Asp Phe Phe Glu Arg Thr Ile Leu Cys Asn 
        35                  40                  45              


Ser Leu Val Trp Ser Cys Ala Val Thr Gly Arg Pro Gly Leu Thr Tyr 
    50                  55                  60                  


Gln Glu Ala Leu Glu Ser Glu Lys Lys Ala Arg Gln Asn Leu Gln Ser 
65                  70                  75                  80  


Phe Pro Glu Pro Leu Ile Ile Pro Val Leu Tyr Leu Thr Ser Leu Thr 
                85                  90                  95      


His Arg Ser Arg Leu His Glu Ile Cys Asp Asp Ile Phe Ala Tyr Val 
            100                 105                 110         


Lys Asp Arg Tyr Phe Val Glu Glu Thr Val Glu Val Ile Arg Asn Asn 
        115                 120                 125             


Gly Ala Arg Leu Gln Cys Arg Ile Leu Glu Val Leu Pro Pro Ser His 
    130                 135                 140                 


Gln Asn Gly Phe Ala Asn Gly His Val Asn Ser Val Asp Gly Glu Thr 
145                 150                 155                 160 


Ile Ile Ile Ser Asp Ser Asp Asp Ser Glu Thr Gln Ser Cys Ser Phe 
                165                 170                 175     


Gln Asn Gly Lys Lys Lys Asp Ala Ile Asp Pro Leu Leu Phe Lys Tyr 
            180                 185                 190         


Lys Val Gln Pro Thr Lys Lys Glu Leu His Glu Ser Ala Ile Val Lys 
        195                 200                 205             


Ala Thr Gln Ile Ser Arg Arg Lys His Leu Phe Ser Arg Asp Lys Leu 
    210                 215                 220                 


Lys Leu Phe Leu Lys Gln His Cys Glu Pro Gln Asp Gly Val Ile Lys 
225                 230                 235                 240 


Ile Lys Ala Ser Ser Leu Ser Thr Tyr Lys Ile Ala Glu Gln Asp Phe 
                245                 250                 255     


Ser Tyr Phe Phe Pro Asp Asp Pro Pro Thr Phe Ile Phe Ser Pro Ala 
            260                 265                 270         


Asn Arg Arg Arg Gly Arg Pro Pro Lys Arg Ile His Ile Ser Gln Glu 
        275                 280                 285             


Asp Asn Val Ala Asn Lys Gln Thr Leu Ala Ser Tyr Arg Ser Lys Ala 
    290                 295                 300                 


Thr Lys Glu Arg Asp Lys Leu Leu Lys Gln Glu Glu Met Lys Ser Leu 
305                 310                 315                 320 


Ala Phe Glu Lys Ala Lys Leu Lys Arg Glu Lys Ala Asp Ala Leu Glu 
                325                 330                 335     


Ala Lys Lys Lys Glu Lys Glu Asp Lys Glu Lys Lys Arg Glu Glu Leu 
            340                 345                 350         


Lys Lys Ile Val Glu Glu Glu Arg Leu Lys Lys Lys Glu Glu Lys Glu 
        355                 360                 365             


Arg Leu Lys Val Glu Arg Glu Lys Glu Arg Glu Lys Leu Arg Glu Glu 
    370                 375                 380                 


Lys Arg Lys Tyr Val Glu Tyr Leu Lys Gln Trp Ser Lys Pro Arg Glu 
385                 390                 395                 400 


Asp Met Glu Cys Asp Asp Leu Lys Glu Leu Pro Glu Pro Thr Pro Val 
                405                 410                 415     


Lys Thr Arg Leu Pro Pro Glu Ile Phe Gly Asp Ala Leu Met Val Leu 
            420                 425                 430         


Glu Phe Leu Asn Ala Phe Gly Glu Leu Phe Asp Leu Gln Asp Glu Phe 
        435                 440                 445             


Pro Asp Gly Val Thr Leu Glu Val Leu Glu Glu Ala Leu Val Gly Asn 
    450                 455                 460                 


Asp Ser Glu Gly Pro Leu Cys Glu Leu Leu Phe Phe Phe Leu Thr Ala 
465                 470                 475                 480 


Ile Phe Gln Ala Ile Ala Glu Glu Glu Glu Glu Val Ala Lys Glu Gln 
                485                 490                 495     


Leu Thr Asp Ala Asp Thr Lys Asp Leu Thr Glu Ala Leu Asp Glu Asp 
            500                 505                 510         


Ala Asp Pro Thr Lys Ser Ala Leu Ser Ala Val Ala Ser Leu Ala Ala 
        515                 520                 525             


Ala Trp Pro Gln Leu His Gln Gly Cys Ser Leu Lys Ser Leu Asp Leu 
    530                 535                 540                 


Asp Ser Cys Thr Leu Ser Glu Ile Leu Arg Leu His Ile Leu Ala Ser 
545                 550                 555                 560 


Gly Ala Asp Val Thr Ser Ala Asn Ala Lys Tyr Arg Tyr Gln Lys Arg 
                565                 570                 575     


Gly Gly Phe Asp Ala Thr Asp Asp Ala Cys Met Glu Leu Arg Leu Ser 
            580                 585                 590         


Asn Pro Ser Leu Val Lys Lys Leu Ser Ser Thr Ser Val Tyr Asp Leu 
        595                 600                 605             


Thr Pro Gly Glu Lys Met Lys Ile Leu His Ala Leu Cys Gly Lys Leu 
    610                 615                 620                 


Leu Thr Leu Val Ser Thr Arg Asp Phe Ile Glu Asp Tyr Val Asp Ile 
625                 630                 635                 640 


Leu Arg Gln Ala Lys Gln Glu Phe Arg Glu Leu Lys Ala Glu Gln His 
                645                 650                 655     


Arg Lys Glu Arg Glu Glu Ala Ala Ala Arg Ile Arg Lys Arg Lys Glu 
            660                 665                 670         


Glu Lys Leu Lys Glu Gln Glu Gln Lys Met Lys Glu Lys Gln Glu Lys 
        675                 680                 685             


Leu Lys Glu Asp Glu Gln Arg Asn Ser Thr Ala Asp Ile Ser Ile Gly 
    690                 695                 700                 


Glu Glu Glu Arg Glu Asp Phe Asp Thr Ser Ile Glu Ser Lys Asp Thr 
705                 710                 715                 720 


Glu Gln Lys Glu Leu Asp Gln Asp Met Val Thr Glu Asp Glu Asp Asp 
                725                 730                 735     


Pro Gly Ser His Lys Arg Gly Arg Arg Gly Lys Arg Gly Gln Asn Gly 
            740                 745                 750         


Phe Lys Glu Phe Thr Arg Gln Glu Gln Ile Asn Cys Val Thr Arg Glu 
        755                 760                 765             


Pro Leu Thr Ala Asp Glu Glu Glu Ala Leu Lys Gln Glu His Gln Arg 
    770                 775                 780                 


Lys Glu Lys Glu Leu Leu Glu Lys Ile Gln Ser Ala Ile Ala Cys Thr 
785                 790                 795                 800 


Asn Ile Phe Pro Leu Gly Arg Asp Arg Met Tyr Arg Arg Tyr Trp Ile 
                805                 810                 815     


Phe Pro Ser Ile Pro Gly Leu Phe Ile Glu Glu Asp Tyr Ser Gly Leu 
            820                 825                 830         


Thr Glu Asp Met Leu Leu Pro Arg Pro Ser Ser Phe Gln Asn Asn Val 
        835                 840                 845             


Gln Ser Gln Asp Pro Gln Val Ser Thr Lys Thr Gly Glu Pro Leu Met 
    850                 855                 860                 


Ser Glu Ser Thr Ser Asn Ile Asp Gln Gly Pro Arg Asp His Ser Val 
865                 870                 875                 880 


Gln Leu Pro Lys Pro Val His Lys Pro Asn Arg Trp Cys Phe Tyr Ser 
                885                 890                 895     


Ser Cys Glu Gln Leu Asp Gln Leu Ile Glu Ala Leu Asn Ser Arg Gly 
            900                 905                 910         


His Arg Glu Ser Ala Leu Lys Glu Thr Leu Leu Gln Glu Lys Ser Arg 
        915                 920                 925             


Ile Cys Ala Gln Leu Ala Arg Phe Ser Glu Glu Lys Phe His Phe Ser 
    930                 935                 940                 


Asp Lys Pro Gln Pro Asp Ser Lys Pro Thr Tyr Ser Arg Gly Arg Ser 
945                 950                 955                 960 


Ser Asn Ala Tyr Asp Pro Ser Gln Met Cys Ala Glu Lys Gln Leu Glu 
                965                 970                 975     


Leu Arg Leu Arg Asp Phe Leu Leu Asp Ile Glu Asp Arg Ile Tyr Gln 
            980                 985                 990         


Gly Thr Leu Gly Ala Ile Lys Val  Thr Asp Arg His Ile  Trp Arg Ser 
        995                 1000                 1005             


Ala Leu  Glu Ser Gly Arg Tyr  Glu Leu Leu Ser Glu  Glu Asn Lys 
    1010                 1015                 1020             


Glu Asn  Gly Ile Ile Lys Thr  Val Asn Glu Asp Val  Glu Glu Met 
    1025                 1030                 1035             


Glu Ile  Asp Glu Gln Thr Lys  Val Ile Val Lys Asp  Arg Leu Leu 
    1040                 1045                 1050             


Gly Ile  Lys Thr Glu Thr Pro  Ser Thr Val Ser Thr  Asn Ala Ser 
    1055                 1060                 1065             


Thr Pro  Gln Ser Val Ser Ser  Val Val His Tyr Leu  Ala Met Ala 
    1070                 1075                 1080             


Leu Phe  Gln Ile Glu Gln Gly  Ile Glu Arg Arg Phe  Leu Lys Ala 
    1085                 1090                 1095             


Pro Leu  Asp Ala Ser Asp Ser  Gly Arg Ser Tyr Lys  Thr Val Leu 
    1100                 1105                 1110             


Asp Arg  Trp Arg Glu Ser Leu  Leu Ser Ser Ala Ser  Leu Ser Gln 
    1115                 1120                 1125             


Val Phe  Leu His Leu Ser Thr  Leu Asp Arg Ser Val  Ile Trp Ser 
    1130                 1135                 1140             


Lys Ser  Ile Leu Asn Ala Arg  Cys Lys Ile Cys Arg  Lys Lys Gly 
    1145                 1150                 1155             


Asp Ala  Glu Asn Met Val Leu  Cys Asp Gly Cys Asp  Arg Gly His 
    1160                 1165                 1170             


His Thr  Tyr Cys Val Arg Pro  Lys Leu Lys Thr Val  Pro Glu Gly 
    1175                 1180                 1185             


Asp Trp  Phe Cys Pro Glu Cys  Arg Pro Lys Gln Arg  Ser Arg Arg 
    1190                 1195                 1200             


Leu Ser  Ser Arg Gln Arg Pro  Ser Leu Glu Ser Asp  Glu Asp Val 
    1205                 1210                 1215             


Glu Asp  Ser Met Gly Gly Glu  Asp Asp Glu Val Asp  Gly Asp Glu 
    1220                 1225                 1230             


Glu Glu  Gly Gln Ser Glu Glu  Glu Glu Tyr Glu Val  Glu Gln Asp 
    1235                 1240                 1245             


Glu Asp  Asp Ser Gln Glu Glu  Glu Glu Val Ser Leu  Pro Lys Arg 
    1250                 1255                 1260             


Gly Arg  Pro Gln Val Arg Leu  Pro Val Lys Thr Arg  Gly Lys Leu 
    1265                 1270                 1275             


Ser Ser  Ser Phe Ser Ser Arg  Gly Gln Gln Gln Glu  Pro Gly Arg 
    1280                 1285                 1290             


Tyr Pro  Ser Arg Ser Gln Gln  Ser Thr Pro Lys Thr  Thr Val Ser 
    1295                 1300                 1305             


Ser Lys  Thr Gly Arg Ser Leu  Arg Lys Ile Asn Ser  Ala Pro Pro 
    1310                 1315                 1320             


Thr Glu  Thr Lys Ser Leu Arg  Ile Ala Ser Arg Ser  Thr Arg His 
    1325                 1330                 1335             


Ser His  Gly Pro Leu Gln Ala  Asp Val Phe Val Glu  Leu Leu Ser 
    1340                 1345                 1350             


Pro Arg  Arg Lys Arg Arg Gly  Arg Lys Ser Ala Asn  Asn Thr Pro 
    1355                 1360                 1365             


Glu Asn  Ser Pro Asn Phe Pro  Asn Phe Arg Val Ile  Ala Thr Lys 
    1370                 1375                 1380             


Ser Ser  Glu Gln Ser Arg Ser  Val Asn Ile Ala Ser  Lys Leu Ser 
    1385                 1390                 1395             


Leu Gln  Glu Ser Glu Ser Lys  Arg Arg Cys Arg Lys  Arg Gln Ser 
    1400                 1405                 1410             


Pro Glu  Pro Ser Pro Val Thr  Leu Gly Arg Arg Ser  Ser Gly Arg 
    1415                 1420                 1425             


Gln Gly  Gly Val His Glu Leu  Ser Ala Phe Glu Gln  Leu Val Val 
    1430                 1435                 1440             


Glu Leu  Val Arg His Asp Asp  Ser Trp Pro Phe Leu  Lys Leu Val 
    1445                 1450                 1455             


Ser Lys  Ile Gln Val Pro Asp  Tyr Tyr Asp Ile Ile  Lys Lys Pro 
    1460                 1465                 1470             


Ile Ala  Leu Asn Ile Ile Arg  Glu Lys Val Asn Lys  Cys Glu Tyr 
    1475                 1480                 1485             


Lys Leu  Ala Ser Glu Phe Ile  Asp Asp Ile Glu Leu  Met Phe Ser 
    1490                 1495                 1500             


Asn Cys  Phe Glu Tyr Asn Pro  Arg Asn Thr Ser Glu  Ala Lys Ala 
    1505                 1510                 1515             


Gly Thr  Arg Leu Gln Ala Phe  Phe His Ile Gln Ala  Gln Lys Leu 
    1520                 1525                 1530             


Gly Leu  His Val Thr Pro Ser  Asn Val Asp Gln Val  Ser Thr Pro 
    1535                 1540                 1545             


Pro Ala  Ala Lys Lys Ser Arg  Ile 
    1550                 1555     


<210>  1064
<211>  1483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAZ1B__Homo_sapiens__NP_115784

<400>  1064

Met Ala Pro Leu Leu Gly Arg Lys Pro Phe Pro Leu Val Lys Pro Leu 
1               5                   10                  15      


Pro Gly Glu Glu Pro Leu Phe Thr Ile Pro His Thr Gln Glu Ala Phe 
            20                  25                  30          


Arg Thr Arg Glu Glu Tyr Glu Ala Arg Leu Glu Arg Tyr Ser Glu Arg 
        35                  40                  45              


Ile Trp Thr Cys Lys Ser Thr Gly Ser Ser Gln Leu Thr His Lys Glu 
    50                  55                  60                  


Ala Trp Glu Glu Glu Gln Glu Val Ala Glu Leu Leu Lys Glu Glu Phe 
65                  70                  75                  80  


Pro Ala Trp Tyr Glu Lys Leu Val Leu Glu Met Val His His Asn Thr 
                85                  90                  95      


Ala Ser Leu Glu Lys Leu Val Asp Thr Ala Trp Leu Glu Ile Met Thr 
            100                 105                 110         


Lys Tyr Ala Val Gly Glu Glu Cys Asp Phe Glu Val Gly Lys Glu Lys 
        115                 120                 125             


Met Leu Lys Val Lys Ile Val Lys Ile His Pro Leu Glu Lys Val Asp 
    130                 135                 140                 


Glu Glu Ala Thr Glu Lys Lys Ser Asp Gly Ala Cys Asp Ser Pro Ser 
145                 150                 155                 160 


Ser Asp Lys Glu Asn Ser Ser Gln Ile Ala Gln Asp His Gln Lys Lys 
                165                 170                 175     


Glu Thr Val Val Lys Glu Asp Glu Gly Arg Arg Glu Ser Ile Asn Asp 
            180                 185                 190         


Arg Ala Arg Arg Ser Pro Arg Lys Leu Pro Thr Ser Leu Lys Lys Gly 
        195                 200                 205             


Glu Arg Lys Trp Ala Pro Pro Lys Phe Leu Pro His Lys Tyr Asp Val 
    210                 215                 220                 


Lys Leu Gln Asn Glu Asp Lys Ile Ile Ser Asn Val Pro Ala Asp Ser 
225                 230                 235                 240 


Leu Ile Arg Thr Glu Arg Pro Pro Asn Lys Glu Ile Val Arg Tyr Phe 
                245                 250                 255     


Ile Arg His Asn Ala Leu Arg Ala Gly Thr Gly Glu Asn Ala Pro Trp 
            260                 265                 270         


Val Val Glu Asp Glu Leu Val Lys Lys Tyr Ser Leu Pro Ser Lys Phe 
        275                 280                 285             


Ser Asp Phe Leu Leu Asp Pro Tyr Lys Tyr Met Thr Leu Asn Pro Ser 
    290                 295                 300                 


Thr Lys Arg Lys Asn Thr Gly Ser Pro Asp Arg Lys Pro Ser Lys Lys 
305                 310                 315                 320 


Ser Lys Thr Asp Asn Ser Ser Leu Ser Ser Pro Leu Asn Pro Lys Leu 
                325                 330                 335     


Trp Cys His Val His Leu Lys Lys Ser Leu Ser Gly Ser Pro Leu Lys 
            340                 345                 350         


Val Lys Asn Ser Lys Asn Ser Lys Ser Pro Glu Glu His Leu Glu Glu 
        355                 360                 365             


Met Met Lys Met Met Ser Pro Asn Lys Leu His Thr Asn Phe His Ile 
    370                 375                 380                 


Pro Lys Lys Gly Pro Pro Ala Lys Lys Pro Gly Lys His Ser Asp Lys 
385                 390                 395                 400 


Pro Leu Lys Ala Lys Gly Arg Ser Lys Gly Ile Leu Asn Gly Gln Lys 
                405                 410                 415     


Ser Thr Gly Asn Ser Lys Ser Pro Lys Lys Gly Leu Lys Thr Pro Lys 
            420                 425                 430         


Thr Lys Met Lys Gln Met Thr Leu Leu Asp Met Ala Lys Gly Thr Gln 
        435                 440                 445             


Lys Met Thr Arg Ala Pro Arg Asn Ser Gly Gly Thr Pro Arg Thr Ser 
    450                 455                 460                 


Ser Lys Pro His Lys His Leu Pro Pro Ala Ala Leu His Leu Ile Ala 
465                 470                 475                 480 


Tyr Tyr Lys Glu Asn Lys Asp Arg Glu Asp Lys Arg Ser Ala Leu Ser 
                485                 490                 495     


Cys Val Ile Ser Lys Thr Ala Arg Leu Leu Ser Ser Glu Asp Arg Ala 
            500                 505                 510         


Arg Leu Pro Glu Glu Leu Arg Ser Leu Val Gln Lys Arg Tyr Glu Leu 
        515                 520                 525             


Leu Glu His Lys Lys Arg Trp Ala Ser Met Ser Glu Glu Gln Arg Lys 
    530                 535                 540                 


Glu Tyr Leu Lys Lys Lys Arg Glu Glu Leu Lys Lys Lys Leu Lys Glu 
545                 550                 555                 560 


Lys Ala Lys Glu Arg Arg Glu Lys Glu Met Leu Glu Arg Leu Glu Lys 
                565                 570                 575     


Gln Lys Arg Tyr Glu Asp Gln Glu Leu Thr Gly Lys Asn Leu Pro Ala 
            580                 585                 590         


Phe Arg Leu Val Asp Thr Pro Glu Gly Leu Pro Asn Thr Leu Phe Gly 
        595                 600                 605             


Asp Val Ala Met Val Val Glu Phe Leu Ser Cys Tyr Ser Gly Leu Leu 
    610                 615                 620                 


Leu Pro Asp Ala Gln Tyr Pro Ile Thr Ala Val Ser Leu Met Glu Ala 
625                 630                 635                 640 


Leu Ser Ala Asp Lys Gly Gly Phe Leu Tyr Leu Asn Arg Val Leu Val 
                645                 650                 655     


Ile Leu Leu Gln Thr Leu Leu Gln Asp Glu Ile Ala Glu Asp Tyr Gly 
            660                 665                 670         


Glu Leu Gly Met Lys Leu Ser Glu Ile Pro Leu Thr Leu His Ser Val 
        675                 680                 685             


Ser Glu Leu Val Arg Leu Cys Leu Arg Arg Ser Asp Val Gln Glu Glu 
    690                 695                 700                 


Ser Glu Gly Ser Asp Thr Asp Asp Asn Lys Asp Ser Ala Ala Phe Glu 
705                 710                 715                 720 


Asp Asn Glu Val Gln Asp Glu Phe Leu Glu Lys Leu Glu Thr Ser Glu 
                725                 730                 735     


Phe Phe Glu Leu Thr Ser Glu Glu Lys Leu Gln Ile Leu Thr Ala Leu 
            740                 745                 750         


Cys His Arg Ile Leu Met Thr Tyr Ser Val Gln Asp His Met Glu Thr 
        755                 760                 765             


Arg Gln Gln Met Ser Ala Glu Leu Trp Lys Glu Arg Leu Ala Val Leu 
    770                 775                 780                 


Lys Glu Glu Asn Asp Lys Lys Arg Ala Glu Lys Gln Lys Arg Lys Glu 
785                 790                 795                 800 


Met Glu Ala Lys Asn Lys Glu Asn Gly Lys Val Glu Asn Gly Leu Gly 
                805                 810                 815     


Lys Thr Asp Arg Lys Lys Glu Ile Val Lys Phe Glu Pro Gln Val Asp 
            820                 825                 830         


Thr Glu Ala Glu Asp Met Ile Ser Ala Val Lys Ser Arg Arg Leu Leu 
        835                 840                 845             


Ala Ile Gln Ala Lys Lys Glu Arg Glu Ile Gln Glu Arg Glu Met Lys 
    850                 855                 860                 


Val Lys Leu Glu Arg Gln Ala Glu Glu Glu Arg Ile Arg Lys His Lys 
865                 870                 875                 880 


Ala Ala Ala Glu Lys Ala Phe Gln Glu Gly Ile Ala Lys Ala Lys Leu 
                885                 890                 895     


Val Met Arg Arg Thr Pro Ile Gly Thr Asp Arg Asn His Asn Arg Tyr 
            900                 905                 910         


Trp Leu Phe Ser Asp Glu Val Pro Gly Leu Phe Ile Glu Lys Gly Trp 
        915                 920                 925             


Val His Asp Ser Ile Asp Tyr Arg Phe Asn His His Cys Lys Asp His 
    930                 935                 940                 


Thr Val Ser Gly Asp Glu Asp Tyr Cys Pro Arg Ser Lys Lys Ala Asn 
945                 950                 955                 960 


Leu Gly Lys Asn Ala Ser Met Asn Thr Gln His Gly Thr Ala Thr Glu 
                965                 970                 975     


Val Ala Val Glu Thr Thr Thr Pro Lys Gln Gly Gln Asn Leu Trp Phe 
            980                 985                 990         


Leu Cys Asp Ser Gln Lys Glu Leu  Asp Glu Leu Leu Asn  Cys Leu His 
        995                 1000                 1005             


Pro Gln  Gly Ile Arg Glu Ser  Gln Leu Lys Glu Arg  Leu Glu Lys 
    1010                 1015                 1020             


Arg Tyr  Gln Asp Ile Ile His  Ser Ile His Leu Ala  Arg Lys Pro 
    1025                 1030                 1035             


Asn Leu  Gly Leu Lys Ser Cys  Asp Gly Asn Gln Glu  Leu Leu Asn 
    1040                 1045                 1050             


Phe Leu  Arg Ser Asp Leu Ile  Glu Val Ala Thr Arg  Leu Gln Lys 
    1055                 1060                 1065             


Gly Gly  Leu Gly Tyr Val Glu  Glu Thr Ser Glu Phe  Glu Ala Arg 
    1070                 1075                 1080             


Val Ile  Ser Leu Glu Lys Leu  Lys Asp Phe Gly Glu  Cys Val Ile 
    1085                 1090                 1095             


Ala Leu  Gln Ala Ser Val Ile  Lys Lys Phe Leu Gln  Gly Phe Met 
    1100                 1105                 1110             


Ala Pro  Lys Gln Lys Arg Arg  Lys Leu Gln Ser Glu  Asp Ser Ala 
    1115                 1120                 1125             


Lys Thr  Glu Glu Val Asp Glu  Glu Lys Lys Met Val  Glu Glu Ala 
    1130                 1135                 1140             


Lys Val  Ala Ser Ala Leu Glu  Lys Trp Lys Thr Ala  Ile Arg Glu 
    1145                 1150                 1155             


Ala Gln  Thr Phe Ser Arg Met  His Val Leu Leu Gly  Met Leu Asp 
    1160                 1165                 1170             


Ala Cys  Ile Lys Trp Asp Met  Ser Ala Glu Asn Ala  Arg Cys Lys 
    1175                 1180                 1185             


Val Cys  Arg Lys Lys Gly Glu  Asp Asp Lys Leu Ile  Leu Cys Asp 
    1190                 1195                 1200             


Glu Cys  Asn Lys Ala Phe His  Leu Phe Cys Leu Arg  Pro Ala Leu 
    1205                 1210                 1215             


Tyr Glu  Val Pro Asp Gly Glu  Trp Gln Cys Pro Ala  Cys Gln Pro 
    1220                 1225                 1230             


Ala Thr  Ala Arg Arg Asn Ser  Arg Gly Arg Asn Tyr  Thr Glu Glu 
    1235                 1240                 1245             


Ser Ala  Ser Glu Asp Ser Glu  Asp Asp Glu Ser Asp  Glu Glu Glu 
    1250                 1255                 1260             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Asp Tyr  Glu Val Ala 
    1265                 1270                 1275             


Gly Leu  Arg Leu Arg Pro Arg  Lys Thr Ile Arg Gly  Lys His Ser 
    1280                 1285                 1290             


Val Ile  Pro Pro Ala Ala Arg  Ser Gly Arg Arg Pro  Gly Lys Lys 
    1295                 1300                 1305             


Pro His  Ser Thr Arg Arg Ser  Gln Pro Lys Ala Pro  Pro Val Asp 
    1310                 1315                 1320             


Asp Ala  Glu Val Asp Glu Leu  Val Leu Gln Thr Lys  Arg Ser Ser 
    1325                 1330                 1335             


Arg Arg  Gln Ser Leu Glu Leu  Gln Lys Cys Glu Glu  Ile Leu His 
    1340                 1345                 1350             


Lys Ile  Val Lys Tyr Arg Phe  Ser Trp Pro Phe Arg  Glu Pro Val 
    1355                 1360                 1365             


Thr Arg  Asp Glu Ala Glu Asp  Tyr Tyr Asp Val Ile  Thr His Pro 
    1370                 1375                 1380             


Met Asp  Phe Gln Thr Val Gln  Asn Lys Cys Ser Cys  Gly Ser Tyr 
    1385                 1390                 1395             


Arg Ser  Val Gln Glu Phe Leu  Thr Asp Met Lys Gln  Val Phe Thr 
    1400                 1405                 1410             


Asn Ala  Glu Val Tyr Asn Cys  Arg Gly Ser His Val  Leu Ser Cys 
    1415                 1420                 1425             


Met Val  Lys Thr Glu Gln Cys  Leu Val Ala Leu Leu  His Lys His 
    1430                 1435                 1440             


Leu Pro  Gly His Pro Tyr Val  Arg Arg Lys Arg Lys  Lys Phe Pro 
    1445                 1450                 1455             


Asp Arg  Leu Ala Glu Asp Glu  Gly Asp Ser Glu Pro  Glu Ala Val 
    1460                 1465                 1470             


Gly Gln  Ser Arg Gly Arg Arg  Gln Lys Lys 
    1475                 1480             


<210>  1065
<211>  1903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAZ2A__Homo_sapiens__NP_001287834

<400>  1065

Met Glu Ala Asn Asp His Phe Asn Phe Thr Gly Leu Pro Pro Ala Pro 
1               5                   10                  15      


Ala Ala Ser Gly Leu Lys Pro Ser Pro Ser Ser Gly Glu Gly Leu Tyr 
            20                  25                  30          


Thr Asn Gly Ser Pro Met Asn Phe Pro Gln Gln Gly Lys Ser Leu Asn 
        35                  40                  45              


Gly Asp Val Asn Val Asn Gly Leu Ser Thr Val Ser His Thr Thr Thr 
    50                  55                  60                  


Ser Gly Ile Leu Asn Ser Ala Pro His Ser Ser Ser Thr Ser His Leu 
65                  70                  75                  80  


His His Pro Ser Val Ala Tyr Asp Cys Leu Trp Asn Tyr Ser Gln Tyr 
                85                  90                  95      


Pro Ser Ala Asn Pro Gly Ser Asn Leu Lys Asp Pro Pro Leu Leu Ser 
            100                 105                 110         


Gln Phe Ser Gly Gly Gln Tyr Pro Leu Asn Gly Ile Leu Gly Gly Ser 
        115                 120                 125             


Arg Gln Pro Ser Ser Pro Ser His Asn Thr Asn Leu Arg Ala Gly Ser 
    130                 135                 140                 


Gln Glu Phe Trp Ala Asn Gly Thr Gln Ser Pro Met Gly Leu Asn Phe 
145                 150                 155                 160 


Asp Ser Gln Glu Leu Tyr Asp Ser Phe Pro Asp Gln Asn Phe Glu Val 
                165                 170                 175     


Met Pro Asn Gly Pro Pro Ser Phe Phe Thr Ser Pro Gln Thr Ser Pro 
            180                 185                 190         


Met Leu Gly Ser Ser Ile Gln Thr Phe Ala Pro Ser Gln Glu Val Gly 
        195                 200                 205             


Ser Gly Ile His Pro Asp Glu Ala Ala Glu Lys Glu Met Thr Ser Val 
    210                 215                 220                 


Val Ala Glu Asn Gly Thr Gly Leu Val Gly Ser Leu Glu Leu Glu Glu 
225                 230                 235                 240 


Glu Gln Pro Glu Leu Lys Met Cys Gly Tyr Asn Gly Ser Val Pro Ser 
                245                 250                 255     


Val Glu Ser Leu His Gln Glu Val Ser Val Leu Val Pro Asp Pro Thr 
            260                 265                 270         


Val Ser Cys Leu Asp Asp Pro Ser His Leu Pro Asp Gln Leu Glu Asp 
        275                 280                 285             


Thr Pro Ile Leu Ser Glu Asp Ser Leu Glu Pro Phe Asn Ser Leu Ala 
    290                 295                 300                 


Pro Glu Pro Val Ser Gly Gly Leu Tyr Gly Ile Asp Asp Thr Glu Leu 
305                 310                 315                 320 


Met Gly Ala Glu Asp Lys Leu Pro Leu Glu Asp Ser Pro Val Ile Ser 
                325                 330                 335     


Ala Leu Asp Cys Pro Ser Leu Asn Asn Ala Thr Ala Phe Ser Leu Leu 
            340                 345                 350         


Ala Asp Asp Ser Gln Thr Ser Thr Ser Ile Phe Ala Ser Pro Thr Ser 
        355                 360                 365             


Pro Pro Val Leu Gly Glu Ser Val Leu Gln Asp Asn Ser Phe Asp Leu 
    370                 375                 380                 


Asn Asn Gly Ser Asp Ala Glu Gln Glu Glu Met Glu Thr Gln Ser Ser 
385                 390                 395                 400 


Asp Phe Pro Pro Ser Leu Thr Gln Pro Ala Pro Asp Gln Ser Ser Thr 
                405                 410                 415     


Ile Gln Leu His Pro Ala Thr Ser Pro Ala Val Ser Pro Thr Thr Ser 
            420                 425                 430         


Pro Ala Val Ser Leu Val Val Ser Pro Ala Ala Ser Pro Glu Ile Ser 
        435                 440                 445             


Pro Glu Val Cys Pro Ala Ala Ser Thr Val Val Ser Pro Ala Val Phe 
    450                 455                 460                 


Ser Val Val Ser Pro Ala Ser Ser Ala Val Leu Pro Ala Val Ser Leu 
465                 470                 475                 480 


Glu Val Pro Leu Thr Ala Ser Val Thr Ser Pro Lys Ala Ser Pro Val 
                485                 490                 495     


Thr Ser Pro Ala Ala Ala Phe Pro Thr Ala Ser Pro Ala Asn Lys Asp 
            500                 505                 510         


Val Ser Ser Phe Leu Glu Thr Thr Ala Asp Val Glu Glu Ile Thr Gly 
        515                 520                 525             


Glu Gly Leu Thr Ala Ser Gly Ser Gly Asp Val Met Arg Arg Arg Ile 
    530                 535                 540                 


Ala Thr Pro Glu Glu Val Arg Leu Pro Leu Gln His Gly Trp Arg Arg 
545                 550                 555                 560 


Glu Val Arg Ile Lys Lys Gly Ser His Arg Trp Gln Gly Glu Thr Trp 
                565                 570                 575     


Tyr Tyr Gly Pro Cys Gly Lys Arg Met Lys Gln Phe Pro Glu Val Ile 
            580                 585                 590         


Lys Tyr Leu Ser Arg Asn Val Val His Ser Val Arg Arg Glu His Phe 
        595                 600                 605             


Ser Phe Ser Pro Arg Met Pro Val Gly Asp Phe Phe Glu Glu Arg Asp 
    610                 615                 620                 


Thr Pro Glu Gly Leu Gln Trp Val Gln Leu Ser Ala Glu Glu Ile Pro 
625                 630                 635                 640 


Ser Arg Ile Gln Ala Ile Thr Gly Lys Arg Gly Arg Pro Arg Asn Thr 
                645                 650                 655     


Glu Lys Ala Lys Thr Lys Glu Val Pro Lys Val Lys Arg Gly Arg Gly 
            660                 665                 670         


Arg Pro Pro Lys Val Lys Ile Thr Glu Leu Leu Asn Lys Thr Asp Asn 
        675                 680                 685             


Arg Pro Leu Lys Lys Leu Glu Ala Gln Glu Thr Leu Asn Glu Glu Asp 
    690                 695                 700                 


Lys Ala Lys Ile Ala Lys Ser Lys Lys Lys Met Arg Gln Lys Val Gln 
705                 710                 715                 720 


Arg Gly Glu Cys Gln Thr Thr Ile Gln Gly Gln Ala Arg Asn Lys Arg 
                725                 730                 735     


Lys Gln Glu Thr Lys Ser Leu Lys Gln Lys Glu Ala Lys Lys Lys Ser 
            740                 745                 750         


Lys Ala Glu Lys Glu Lys Gly Lys Thr Lys Gln Glu Lys Leu Lys Glu 
        755                 760                 765             


Lys Val Lys Arg Glu Lys Lys Glu Lys Val Lys Met Lys Glu Lys Glu 
    770                 775                 780                 


Glu Val Thr Lys Ala Lys Pro Ala Cys Lys Ala Asp Lys Thr Leu Ala 
785                 790                 795                 800 


Thr Gln Arg Arg Leu Glu Glu Arg Gln Arg Gln Gln Met Ile Leu Glu 
                805                 810                 815     


Glu Met Lys Lys Pro Thr Glu Asp Met Cys Leu Thr Asp His Gln Pro 
            820                 825                 830         


Leu Pro Asp Phe Ser Arg Val Pro Gly Leu Thr Leu Pro Ser Gly Ala 
        835                 840                 845             


Phe Ser Asp Cys Leu Thr Ile Val Glu Phe Leu His Ser Phe Gly Lys 
    850                 855                 860                 


Val Leu Gly Phe Asp Pro Ala Lys Asp Val Pro Ser Leu Gly Val Leu 
865                 870                 875                 880 


Gln Glu Gly Leu Leu Cys Gln Gly Asp Ser Leu Gly Glu Val Gln Asp 
                885                 890                 895     


Leu Leu Val Arg Leu Leu Lys Ala Ala Leu His Asp Pro Gly Phe Pro 
            900                 905                 910         


Ser Tyr Cys Gln Ser Leu Lys Ile Leu Gly Glu Lys Val Ser Glu Ile 
        915                 920                 925             


Pro Leu Thr Arg Asp Asn Val Ser Glu Ile Leu Arg Cys Phe Leu Met 
    930                 935                 940                 


Ala Tyr Gly Val Glu Pro Ala Leu Cys Asp Arg Leu Arg Thr Gln Pro 
945                 950                 955                 960 


Phe Gln Ala Gln Pro Pro Gln Gln Lys Ala Ala Val Leu Ala Phe Leu 
                965                 970                 975     


Val His Glu Leu Asn Gly Ser Thr Leu Ile Ile Asn Glu Ile Asp Lys 
            980                 985                 990         


Thr Leu Glu Ser Met Ser Ser Tyr  Arg Lys Asn Lys Trp  Ile Val Glu 
        995                 1000                 1005             


Gly Arg  Leu Arg Arg Leu Lys  Thr Val Leu Ala Lys  Arg Thr Gly 
    1010                 1015                 1020             


Arg Ser  Glu Val Glu Met Glu  Gly Pro Glu Glu Cys  Leu Gly Arg 
    1025                 1030                 1035             


Arg Arg  Ser Ser Arg Ile Met  Glu Glu Thr Ser Gly  Met Glu Glu 
    1040                 1045                 1050             


Glu Glu  Glu Glu Glu Ser Ile  Ala Ala Val Pro Gly  Arg Arg Gly 
    1055                 1060                 1065             


Arg Arg  Asp Gly Glu Val Asp  Ala Thr Ala Ser Ser  Ile Pro Glu 
    1070                 1075                 1080             


Leu Glu  Arg Gln Ile Glu Lys  Leu Ser Lys Arg Gln  Leu Phe Phe 
    1085                 1090                 1095             


Arg Lys  Lys Leu Leu His Ser  Ser Gln Met Leu Arg  Ala Val Ser 
    1100                 1105                 1110             


Leu Gly  Gln Asp Arg Tyr Arg  Arg Arg Tyr Trp Val  Leu Pro Tyr 
    1115                 1120                 1125             


Leu Ala  Gly Ile Phe Val Glu  Gly Thr Glu Gly Asn  Leu Val Pro 
    1130                 1135                 1140             


Glu Glu  Val Ile Lys Lys Glu  Thr Asp Ser Leu Lys  Val Ala Ala 
    1145                 1150                 1155             


His Ala  Ser Leu Asn Pro Ala  Leu Phe Ser Met Lys  Met Glu Leu 
    1160                 1165                 1170             


Ala Gly  Ser Asn Thr Thr Ala  Ser Ser Pro Ala Arg  Ala Arg Gly 
    1175                 1180                 1185             


Arg Pro  Arg Lys Thr Lys Pro  Gly Ser Met Gln Pro  Arg His Leu 
    1190                 1195                 1200             


Lys Ser  Pro Val Arg Gly Gln  Asp Ser Glu Gln Pro  Gln Ala Gln 
    1205                 1210                 1215             


Leu Gln  Pro Glu Ala Gln Leu  His Ala Pro Ala Gln  Pro Gln Pro 
    1220                 1225                 1230             


Gln Leu  Gln Leu Gln Leu Gln  Ser His Lys Gly Phe  Leu Glu Gln 
    1235                 1240                 1245             


Glu Gly  Ser Pro Leu Ser Leu  Gly Gln Ser Gln His  Asp Leu Ser 
    1250                 1255                 1260             


Gln Ser  Ala Phe Leu Ser Trp  Leu Ser Gln Thr Gln  Ser His Ser 
    1265                 1270                 1275             


Ser Leu  Leu Ser Ser Ser Val  Leu Thr Pro Asp Ser  Ser Pro Gly 
    1280                 1285                 1290             


Lys Leu  Asp Pro Ala Pro Ser  Gln Pro Pro Glu Glu  Pro Glu Pro 
    1295                 1300                 1305             


Asp Glu  Ala Glu Ser Ser Pro  Asp Pro Gln Ala Leu  Trp Phe Asn 
    1310                 1315                 1320             


Ile Ser  Ala Gln Met Pro Cys  Asn Ala Ala Pro Thr  Pro Pro Pro 
    1325                 1330                 1335             


Ala Val  Ser Glu Asp Gln Pro  Thr Pro Ser Pro Gln  Gln Leu Ala 
    1340                 1345                 1350             


Ser Ser  Lys Pro Met Asn Arg  Pro Ser Ala Ala Asn  Pro Cys Ser 
    1355                 1360                 1365             


Pro Val  Gln Phe Ser Ser Thr  Pro Leu Ala Gly Leu  Ala Pro Lys 
    1370                 1375                 1380             


Arg Arg  Ala Gly Asp Pro Gly  Glu Met Pro Gln Ser  Pro Thr Gly 
    1385                 1390                 1395             


Leu Gly  Gln Pro Lys Arg Arg  Gly Arg Pro Pro Ser  Lys Phe Phe 
    1400                 1405                 1410             


Lys Gln  Met Glu Gln Arg Tyr  Leu Thr Gln Leu Thr  Ala Gln Pro 
    1415                 1420                 1425             


Val Pro  Pro Glu Met Cys Ser  Gly Trp Trp Trp Ile  Arg Asp Pro 
    1430                 1435                 1440             


Glu Met  Leu Asp Ala Met Leu  Lys Ala Leu His Pro  Arg Gly Ile 
    1445                 1450                 1455             


Arg Glu  Lys Ala Leu His Lys  His Leu Asn Lys His  Arg Asp Phe 
    1460                 1465                 1470             


Leu Gln  Glu Val Cys Leu Arg  Pro Ser Ala Asp Pro  Ile Phe Glu 
    1475                 1480                 1485             


Pro Arg  Gln Leu Pro Ala Phe  Gln Glu Gly Ile Met  Ser Trp Ser 
    1490                 1495                 1500             


Pro Lys  Glu Lys Thr Tyr Glu  Thr Asp Leu Ala Val  Leu Gln Trp 
    1505                 1510                 1515             


Val Glu  Glu Leu Glu Gln Arg  Val Ile Met Ser Asp  Leu Gln Ile 
    1520                 1525                 1530             


Arg Gly  Trp Thr Cys Pro Ser  Pro Asp Ser Thr Arg  Glu Asp Leu 
    1535                 1540                 1545             


Ala Tyr  Cys Glu His Leu Ser  Asp Ser Gln Glu Asp  Ile Thr Trp 
    1550                 1555                 1560             


Arg Gly  Arg Gly Arg Glu Gly  Leu Ala Pro Gln Arg  Lys Thr Thr 
    1565                 1570                 1575             


Asn Pro  Leu Asp Leu Ala Val  Met Arg Leu Ala Ala  Leu Glu Gln 
    1580                 1585                 1590             


Asn Val  Glu Arg Arg Tyr Leu  Arg Glu Pro Leu Trp  Pro Thr His 
    1595                 1600                 1605             


Glu Val  Val Leu Glu Lys Ala  Leu Leu Ser Thr Pro  Asn Gly Ala 
    1610                 1615                 1620             


Pro Glu  Gly Thr Thr Thr Glu  Ile Ser Tyr Glu Ile  Thr Pro Arg 
    1625                 1630                 1635             


Ile Arg  Val Trp Arg Gln Thr  Leu Glu Arg Cys Arg  Ser Ala Ala 
    1640                 1645                 1650             


Gln Val  Cys Leu Cys Leu Gly  Gln Leu Glu Arg Ser  Ile Ala Trp 
    1655                 1660                 1665             


Glu Lys  Ser Val Asn Lys Val  Thr Cys Leu Val Cys  Arg Lys Gly 
    1670                 1675                 1680             


Asp Asn  Asp Glu Phe Leu Leu  Leu Cys Asp Gly Cys  Asp Arg Gly 
    1685                 1690                 1695             


Cys His  Ile Tyr Cys His Arg  Pro Lys Met Glu Ala  Val Pro Glu 
    1700                 1705                 1710             


Gly Asp  Trp Phe Cys Thr Val  Cys Leu Ala Gln Gln  Val Glu Gly 
    1715                 1720                 1725             


Glu Phe  Thr Gln Lys Pro Gly  Phe Pro Lys Arg Gly  Gln Lys Arg 
    1730                 1735                 1740             


Lys Ser  Gly Tyr Ser Leu Asn  Phe Ser Glu Gly Asp  Gly Arg Arg 
    1745                 1750                 1755             


Arg Arg  Val Leu Leu Arg Gly  Arg Glu Ser Pro Ala  Ala Gly Pro 
    1760                 1765                 1770             


Arg Tyr  Ser Glu Glu Gly Leu  Ser Pro Ser Lys Arg  Arg Arg Leu 
    1775                 1780                 1785             


Ser Met  Arg Asn His His Ser  Asp Leu Thr Phe Cys  Glu Ile Ile 
    1790                 1795                 1800             


Leu Met  Glu Met Glu Ser His  Asp Ala Ala Trp Pro  Phe Leu Glu 
    1805                 1810                 1815             


Pro Val  Asn Pro Arg Leu Val  Ser Gly Tyr Arg Arg  Ile Ile Lys 
    1820                 1825                 1830             


Asn Pro  Met Asp Phe Ser Thr  Met Arg Glu Arg Leu  Leu Arg Gly 
    1835                 1840                 1845             


Gly Tyr  Thr Ser Ser Glu Glu  Phe Ala Ala Asp Ala  Leu Leu Val 
    1850                 1855                 1860             


Phe Asp  Asn Cys Gln Thr Phe  Asn Glu Asp Asp Ser  Glu Val Gly 
    1865                 1870                 1875             


Lys Ala  Gly His Ile Met Arg  Arg Phe Phe Glu Ser  Arg Trp Glu 
    1880                 1885                 1890             


Glu Phe  Tyr Gln Gly Lys Gln  Ala Asn Leu 
    1895                 1900             


<210>  1066
<211>  2132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BAZ2B__Homo_sapiens__NP_001276904

<400>  1066

Met Glu Ser Gly Glu Arg Leu Pro Ser Ser Ala Ala Ser Ser Thr Thr 
1               5                   10                  15      


Pro Thr Ser Ser Ser Thr Pro Ser Val Ala Ser Val Val Ser Lys Gly 
            20                  25                  30          


Gly Leu Ser Thr Gly Val Ala Ser Leu Ser Ser Thr Ile Asn Pro Cys 
        35                  40                  45              


Gly His Leu Phe Arg Thr Ala Gly Asp Gln Pro Phe Asn Leu Ser Thr 
    50                  55                  60                  


Val Ser Ser Ala Phe Pro Met Val Ser His Pro Val Phe Gly Leu His 
65                  70                  75                  80  


Ser Ala Ser Ser Gly His Ser Glu Phe Gly Gly Leu Gly Thr Leu Gly 
                85                  90                  95      


Thr Pro Thr Ala Leu Ala Ala His Pro Gln Leu Ala Ser Phe Pro Glu 
            100                 105                 110         


Trp Trp Arg Thr Thr Asp Ala His Thr Arg Thr Gly Ala Thr Phe Phe 
        115                 120                 125             


Pro Pro Leu Leu Gly Ile Pro Pro Leu Phe Ala Pro Pro Ala Gln Asn 
    130                 135                 140                 


His Asp Ser Ser Ser Phe His Ser Arg Thr Ser Gly Lys Ser Asn Arg 
145                 150                 155                 160 


Asn Gly Pro Glu Lys Gly Val Asn Gly Ser Ile Asn Gly Ser Asn Thr 
                165                 170                 175     


Ser Ser Val Ile Gly Ile Asn Thr Ser Val Leu Ser Thr Thr Ala Ser 
            180                 185                 190         


Ser Ser Met Gly Gln Thr Lys Ser Thr Ser Ser Gly Gly Gly Asn Arg 
        195                 200                 205             


Lys Cys Asn Gln Glu Gln Ser Lys Asn Gln Pro Leu Asp Ala Arg Val 
    210                 215                 220                 


Asp Lys Ile Lys Asp Lys Lys Pro Arg Lys Lys Ala Met Glu Ser Ser 
225                 230                 235                 240 


Ser Asn Ser Asp Ser Asp Ser Gly Thr Ser Ser Asp Thr Ser Ser Glu 
                245                 250                 255     


Gly Ile Ser Ser Ser Asp Ser Asp Asp Leu Glu Glu Asp Glu Glu Glu 
            260                 265                 270         


Glu Asp Gln Ser Ile Glu Glu Ser Glu Asp Asp Asp Ser Asp Ser Glu 
        275                 280                 285             


Ser Glu Ala Gln His Lys Ser Asn Asn Gln Val Leu Leu His Gly Ile 
    290                 295                 300                 


Ser Asp Pro Lys Ala Asp Gly Gln Lys Ala Thr Glu Lys Ala Gln Glu 
305                 310                 315                 320 


Lys Arg Ile His Gln Pro Leu Pro Leu Ala Ser Glu Ser Gln Thr His 
                325                 330                 335     


Ser Phe Gln Ser Gln Gln Lys Gln Pro Gln Val Leu Ser Gln Gln Leu 
            340                 345                 350         


Pro Phe Ile Phe Gln Ser Ser Gln Ala Lys Glu Glu Ser Val Asn Lys 
        355                 360                 365             


His Thr Ser Val Ile Gln Ser Thr Gly Leu Val Ser Asn Val Lys Pro 
    370                 375                 380                 


Leu Ser Leu Val Asn Gln Ala Lys Lys Glu Thr Tyr Met Lys Leu Ile 
385                 390                 395                 400 


Val Pro Ser Pro Asp Val Leu Lys Ala Gly Asn Lys Asn Thr Ser Glu 
                405                 410                 415     


Glu Ser Ser Leu Leu Thr Ser Glu Leu Arg Ser Lys Arg Glu Gln Tyr 
            420                 425                 430         


Lys Gln Ala Phe Pro Ser Gln Leu Lys Lys Gln Glu Ser Ser Lys Ser 
        435                 440                 445             


Leu Lys Lys Val Ile Ala Ala Leu Ser Asn Pro Lys Ala Thr Ser Ser 
    450                 455                 460                 


Ser Pro Ala His Pro Lys Gln Thr Leu Glu Asn Asn His Pro Asn Pro 
465                 470                 475                 480 


Phe Leu Thr Asn Ala Leu Leu Gly Asn His Gln Pro Asn Gly Val Ile 
                485                 490                 495     


Gln Ser Val Ile Gln Glu Ala Pro Leu Ala Leu Thr Thr Lys Thr Lys 
            500                 505                 510         


Met Gln Ser Lys Ile Asn Glu Asn Ile Ala Ala Ala Ser Ser Thr Pro 
        515                 520                 525             


Phe Ser Ser Pro Val Asn Leu Ser Thr Ser Gly Arg Arg Thr Pro Gly 
    530                 535                 540                 


Asn Gln Thr Pro Val Met Pro Ser Ala Ser Pro Ile Leu His Ser Gln 
545                 550                 555                 560 


Gly Lys Glu Lys Ala Val Ser Asn Asn Val Asn Pro Val Lys Thr Gln 
                565                 570                 575     


His His Ser His Pro Ala Lys Ser Leu Val Glu Gln Phe Arg Gly Thr 
            580                 585                 590         


Asp Ser Asp Ile Pro Ser Ser Lys Asp Ser Glu Asp Ser Asn Glu Asp 
        595                 600                 605             


Glu Glu Glu Asp Asp Glu Glu Glu Asp Glu Glu Asp Asp Glu Asp Asp 
    610                 615                 620                 


Glu Ser Asp Asp Ser Gln Ser Glu Ser Asp Ser Asn Ser Glu Ser Asp 
625                 630                 635                 640 


Thr Glu Gly Ser Glu Glu Glu Asp Asp Asp Asp Lys Asp Gln Asp Glu 
                645                 650                 655     


Ser Asp Ser Asp Thr Glu Gly Glu Lys Thr Ser Met Lys Leu Asn Lys 
            660                 665                 670         


Thr Thr Ser Ser Val Lys Ser Pro Ser Met Ser Leu Thr Gly His Ser 
        675                 680                 685             


Thr Pro Arg Asn Leu His Ile Ala Lys Ala Pro Gly Ser Ala Pro Ala 
    690                 695                 700                 


Ala Leu Cys Ser Glu Ser Gln Ser Pro Ala Phe Leu Gly Thr Ser Ser 
705                 710                 715                 720 


Ser Thr Leu Thr Ser Ser Pro His Ser Gly Thr Ser Lys Arg Arg Arg 
                725                 730                 735     


Val Thr Asp Glu Arg Glu Leu Arg Ile Pro Leu Glu Tyr Gly Trp Gln 
            740                 745                 750         


Arg Glu Thr Arg Ile Arg Asn Phe Gly Gly Arg Leu Gln Gly Glu Val 
        755                 760                 765             


Ala Tyr Tyr Ala Pro Cys Gly Lys Lys Leu Arg Gln Tyr Pro Glu Val 
    770                 775                 780                 


Ile Lys Gly Met Gln Trp Cys Leu Leu Lys Glu Glu Asp Val Ile Pro 
785                 790                 795                 800 


Arg Ile Arg Ala Met Glu Gly Arg Arg Gly Arg Pro Pro Asn Pro Asp 
                805                 810                 815     


Arg Gln Arg Ala Arg Glu Glu Ser Arg Met Arg Arg Arg Lys Gly Arg 
            820                 825                 830         


Pro Pro Asn Val Gly Asn Ala Glu Phe Leu Asp Asn Ala Asp Ala Lys 
        835                 840                 845             


Leu Leu Arg Lys Leu Gln Ala Gln Glu Ile Ala Arg Gln Ala Ala Gln 
    850                 855                 860                 


Ile Lys Leu Leu Arg Lys Leu Gln Lys Gln Glu Gln Ala Arg Val Ala 
865                 870                 875                 880 


Lys Glu Ala Lys Lys Gln Gln Ala Ile Met Ala Ala Glu Glu Lys Arg 
                885                 890                 895     


Lys Gln Lys Glu Gln Ile Lys Ile Met Lys Gln Gln Glu Lys Ile Lys 
            900                 905                 910         


Arg Ile Gln Gln Ile Arg Met Glu Lys Glu Leu Arg Ala Gln Gln Ile 
        915                 920                 925             


Leu Glu Ala Lys Lys Lys Lys Lys Glu Glu Ala Ala Asn Ala Lys Leu 
    930                 935                 940                 


Leu Glu Ala Glu Lys Arg Ile Lys Glu Lys Glu Met Arg Arg Gln Gln 
945                 950                 955                 960 


Ala Val Leu Leu Lys His Gln Glu Arg Glu Arg Arg Arg Gln His Met 
                965                 970                 975     


Met Leu Met Lys Ala Met Glu Ala Arg Lys Lys Ala Glu Glu Lys Glu 
            980                 985                 990         


Arg Leu Lys Gln Glu Lys Arg Asp  Glu Lys Arg Leu Asn  Lys Glu Arg 
        995                 1000                 1005             


Lys Leu  Glu Gln Arg Arg Leu  Glu Leu Glu Met Ala  Lys Glu Leu 
    1010                 1015                 1020             


Lys Lys  Pro Asn Glu Asp Met  Cys Leu Ala Asp Gln  Lys Pro Leu 
    1025                 1030                 1035             


Pro Glu  Leu Pro Arg Ile Pro  Gly Leu Val Leu Ser  Gly Ser Thr 
    1040                 1045                 1050             


Phe Ser  Asp Cys Leu Met Val  Val Gln Phe Leu Arg  Asn Phe Gly 
    1055                 1060                 1065             


Lys Val  Leu Gly Phe Asp Val  Asn Ile Asp Val Pro  Asn Leu Ser 
    1070                 1075                 1080             


Val Leu  Gln Glu Gly Leu Leu  Asn Ile Gly Asp Ser  Met Gly Glu 
    1085                 1090                 1095             


Val Gln  Asp Leu Leu Val Arg  Leu Leu Ser Ala Ala  Val Cys Asp 
    1100                 1105                 1110             


Pro Gly  Leu Ile Thr Gly Tyr  Lys Ala Lys Thr Ala  Leu Gly Glu 
    1115                 1120                 1125             


His Leu  Leu Asn Val Gly Val  Asn Arg Asp Asn Val  Ser Glu Ile 
    1130                 1135                 1140             


Leu Gln  Ile Phe Met Glu Ala  His Cys Gly Gln Thr  Glu Leu Thr 
    1145                 1150                 1155             


Glu Ser  Leu Lys Thr Lys Ala  Phe Gln Ala His Thr  Pro Ala Gln 
    1160                 1165                 1170             


Lys Ala  Ser Val Leu Ala Phe  Leu Ile Asn Glu Leu  Ala Cys Ser 
    1175                 1180                 1185             


Lys Ser  Val Val Ser Glu Ile  Asp Lys Asn Ile Asp  Tyr Met Ser 
    1190                 1195                 1200             


Asn Leu  Arg Arg Asp Lys Trp  Val Val Glu Gly Lys  Leu Arg Lys 
    1205                 1210                 1215             


Leu Arg  Ile Ile His Ala Lys  Lys Thr Gly Lys Arg  Asp Thr Ser 
    1220                 1225                 1230             


Gly Gly  Ile Asp Leu Gly Glu  Glu Gln His Pro Leu  Gly Thr Pro 
    1235                 1240                 1245             


Thr Pro  Gly Arg Lys Arg Arg  Arg Lys Gly Gly Asp  Ser Asp Tyr 
    1250                 1255                 1260             


Asp Asp  Asp Asp Asp Asp Asp  Ser Asp Asp Gln Gly  Asp Glu Asp 
    1265                 1270                 1275             


Asp Glu  Asp Glu Glu Asp Lys  Glu Asp Lys Lys Gly  Lys Lys Thr 
    1280                 1285                 1290             


Asp Ile  Cys Glu Asp Glu Asp  Glu Gly Asp Gln Ala  Ala Ser Val 
    1295                 1300                 1305             


Glu Glu  Leu Glu Lys Gln Ile  Glu Lys Leu Ser Lys  Gln Gln Ser 
    1310                 1315                 1320             


Gln Tyr  Arg Arg Lys Leu Phe  Asp Ala Ser His Ser  Leu Arg Ser 
    1325                 1330                 1335             


Val Met  Phe Gly Gln Asp Arg  Tyr Arg Arg Arg Tyr  Trp Ile Leu 
    1340                 1345                 1350             


Pro Gln  Cys Gly Gly Ile Phe  Val Glu Gly Met Glu  Ser Gly Glu 
    1355                 1360                 1365             


Gly Leu  Glu Glu Ile Ala Lys  Glu Arg Glu Lys Leu  Lys Lys Ala 
    1370                 1375                 1380             


Glu Ser  Val Gln Ile Lys Glu  Glu Met Phe Glu Thr  Ser Gly Asp 
    1385                 1390                 1395             


Ser Leu  Asn Cys Ser Asn Thr  Asp His Cys Glu Gln  Lys Glu Asp 
    1400                 1405                 1410             


Leu Lys  Glu Lys Asp Asn Thr  Asn Leu Phe Leu Gln  Lys Pro Gly 
    1415                 1420                 1425             


Ser Phe  Ser Lys Leu Ser Lys  Leu Leu Glu Val Ala  Lys Met Pro 
    1430                 1435                 1440             


Pro Glu  Ser Glu Val Met Thr  Pro Lys Pro Asn Ala  Gly Ala Asn 
    1445                 1450                 1455             


Gly Cys  Thr Leu Ser Tyr Gln  Asn Ser Gly Lys His  Ser Leu Gly 
    1460                 1465                 1470             


Ser Val  Gln Ser Thr Ala Thr  Gln Ser Asn Val Glu  Lys Ala Asp 
    1475                 1480                 1485             


Ser Asn  Asn Leu Phe Asn Thr  Gly Ser Ser Gly Pro  Gly Lys Phe 
    1490                 1495                 1500             


Tyr Ser  Pro Leu Pro Asn Asp  Gln Leu Leu Lys Thr  Leu Thr Glu 
    1505                 1510                 1515             


Lys Asn  Arg Gln Trp Phe Ser  Leu Leu Pro Arg Thr  Pro Cys Asp 
    1520                 1525                 1530             


Asp Thr  Ser Leu Thr His Ala  Asp Met Ser Thr Ala  Ser Leu Val 
    1535                 1540                 1545             


Thr Pro  Gln Ser Gln Pro Pro  Ser Lys Ser Pro Ser  Pro Thr Pro 
    1550                 1555                 1560             


Ala Pro  Leu Gly Ser Ser Ala  Gln Asn Pro Val Gly  Leu Asn Pro 
    1565                 1570                 1575             


Phe Ala  Leu Ser Pro Leu Gln  Val Lys Gly Gly Val  Ser Met Met 
    1580                 1585                 1590             


Gly Leu  Gln Phe Cys Gly Trp  Pro Thr Gly Val Val  Thr Ser Asn 
    1595                 1600                 1605             


Ile Pro  Phe Thr Ser Ser Val  Pro Ser Leu Gly Ser  Gly Leu Gly 
    1610                 1615                 1620             


Leu Ser  Glu Gly Asn Gly Asn  Ser Phe Leu Thr Ser  Asn Val Ala 
    1625                 1630                 1635             


Ser Ser  Lys Ser Glu Ser Pro  Val Pro Gln Asn Glu  Lys Ala Thr 
    1640                 1645                 1650             


Ser Ala  Gln Pro Ala Ala Val  Glu Val Ala Lys Pro  Val Asp Phe 
    1655                 1660                 1665             


Pro Ser  Pro Lys Pro Ile Pro  Glu Glu Met Gln Phe  Gly Trp Trp 
    1670                 1675                 1680             


Arg Ile  Ile Asp Pro Glu Asp  Leu Lys Ala Leu Leu  Lys Val Leu 
    1685                 1690                 1695             


His Leu  Arg Gly Ile Arg Glu  Lys Ala Leu Gln Lys  Gln Ile Gln 
    1700                 1705                 1710             


Lys His  Leu Asp Tyr Ile Thr  Gln Ala Cys Leu Lys  Asn Lys Asp 
    1715                 1720                 1725             


Val Ala  Ile Ile Glu Leu Asn  Glu Asn Glu Glu Asn  Gln Val Thr 
    1730                 1735                 1740             


Arg Asp  Ile Val Glu Asn Trp  Ser Val Glu Glu Gln  Ala Met Glu 
    1745                 1750                 1755             


Met Asp  Leu Ser Val Leu Gln  Gln Val Glu Asp Leu  Glu Arg Arg 
    1760                 1765                 1770             


Val Ala  Ser Ala Ser Leu Gln  Val Lys Gly Trp Met  Cys Pro Glu 
    1775                 1780                 1785             


Pro Ala  Ser Glu Arg Glu Asp  Leu Val Tyr Phe Glu  His Lys Ser 
    1790                 1795                 1800             


Phe Thr  Lys Leu Cys Lys Glu  His Asp Gly Glu Phe  Thr Gly Glu 
    1805                 1810                 1815             


Asp Glu  Ser Ser Ala His Ala  Leu Glu Arg Lys Ser  Asp Asn Pro 
    1820                 1825                 1830             


Leu Asp  Ile Ala Val Thr Arg  Leu Ala Asp Leu Glu  Arg Asn Ile 
    1835                 1840                 1845             


Glu Arg  Arg Ile Glu Glu Asp  Ile Ala Pro Gly Leu  Arg Val Trp 
    1850                 1855                 1860             


Arg Arg  Ala Leu Ser Glu Ala  Arg Ser Ala Ala Gln  Val Ala Leu 
    1865                 1870                 1875             


Cys Ile  Gln Gln Leu Gln Lys  Ser Ile Ala Trp Glu  Lys Ser Ile 
    1880                 1885                 1890             


Met Lys  Val Tyr Cys Gln Ile  Cys Arg Lys Gly Asp  Asn Glu Glu 
    1895                 1900                 1905             


Leu Leu  Leu Leu Cys Asp Gly  Cys Asp Lys Gly Cys  His Thr Tyr 
    1910                 1915                 1920             


Cys His  Arg Pro Lys Ile Thr  Thr Ile Pro Asp Gly  Asp Trp Phe 
    1925                 1930                 1935             


Cys Pro  Ala Cys Ile Ala Lys  Ala Ser Gly Gln Thr  Leu Lys Ile 
    1940                 1945                 1950             


Lys Lys  Leu His Val Lys Gly  Lys Lys Thr Asn Glu  Ser Lys Lys 
    1955                 1960                 1965             


Gly Lys  Lys Val Thr Leu Thr  Gly Asp Thr Glu Asp  Glu Asp Ser 
    1970                 1975                 1980             


Ala Ser  Thr Ser Ser Ser Leu  Lys Arg Gly Asn Lys  Asp Leu Lys 
    1985                 1990                 1995             


Lys Arg  Lys Met Glu Glu Asn  Thr Ser Ile Asn Leu  Ser Lys Gln 
    2000                 2005                 2010             


Glu Ser  Phe Thr Ser Val Lys  Lys Pro Lys Arg Asp  Asp Ser Lys 
    2015                 2020                 2025             


Asp Leu  Ala Leu Cys Ser Met  Ile Leu Thr Glu Met  Glu Thr His 
    2030                 2035                 2040             


Glu Asp  Ala Trp Pro Phe Leu  Leu Pro Val Asn Leu  Lys Leu Val 
    2045                 2050                 2055             


Pro Gly  Tyr Lys Lys Val Ile  Lys Lys Pro Met Asp  Phe Ser Thr 
    2060                 2065                 2070             


Ile Arg  Glu Lys Leu Ser Ser  Gly Gln Tyr Pro Asn  Leu Glu Thr 
    2075                 2080                 2085             


Phe Ala  Leu Asp Val Arg Leu  Val Phe Asp Asn Cys  Glu Thr Phe 
    2090                 2095                 2100             


Asn Glu  Asp Asp Ser Asp Ile  Gly Arg Ala Gly His  Asn Met Arg 
    2105                 2110                 2115             


Lys Tyr  Phe Glu Lys Lys Trp  Thr Asp Thr Phe Lys  Val Ser 
    2120                 2125                 2130         


<210>  1067
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBC3__Homo_sapiens__NP_001120712

<400>  1067

Met Lys Phe Gly Met Gly Ser Ala Gln Ala Cys Pro Cys Gln Val Pro 
1               5                   10                  15      


Arg Ala Ala Ser Thr Thr Trp Val Pro Cys Gln Ile Cys Gly Pro Arg 
            20                  25                  30          


Glu Arg His Gly Pro Arg Thr Pro Gly Gly Gln Leu Pro Gly Ala Arg 
        35                  40                  45              


Arg Gly Pro Gly Pro Arg Arg Pro Ala Pro Leu Pro Ala Arg Pro Pro 
    50                  55                  60                  


Gly Ala Leu Gly Ser Val Leu Arg Pro Leu Arg Ala Arg Pro Gly Cys 
65                  70                  75                  80  


Arg Pro Arg Arg Pro His Pro Ala Ala Arg Cys Leu Pro Leu Arg Pro 
                85                  90                  95      


His Arg Pro Thr Arg Arg His Arg Arg Pro Gly Gly Phe Pro Leu Ala 
            100                 105                 110         


Trp Gly Ser Pro Gln Pro Ala Pro Arg Pro Ala Pro Gly Arg Ser Ser 
        115                 120                 125             


Ala Leu Ala Leu Ala Gly Gly Ala Ala Pro Gly Val Ala Arg Ala Gln 
    130                 135                 140                 


Arg Pro Gly Gly Ser Gly Gly Arg Ser His Pro Gly Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Arg Gly Gly Gly Thr Val Gly Pro Gly Asp Arg Gly Pro Ala Ala 
                165                 170                 175     


Ala Asp Gly Gly Arg Pro Gln Arg Thr Val Arg Ala Ala Glu Thr Arg 
            180                 185                 190         


Gly Ala Ala Ala Ala Pro Pro Leu Thr Leu Glu Gly Pro Val Gln Ser 
        195                 200                 205             


His His Gly Thr Pro Ala Leu Thr Gln Gly Pro Gln Ser Pro Arg Asp 
    210                 215                 220                 


Gly Ala Gln Leu Gly Ala Cys Thr Arg Pro Val Asp Val Arg Asp Ser 
225                 230                 235                 240 


Gly Gly Arg Pro Leu Pro Pro Pro Asp Thr Leu Ala Ser Ala Gly Asp 
                245                 250                 255     


Phe Leu Cys Thr Met 
            260     


<210>  1068
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBIP1__Homo_sapiens__NP_001182233

<400>  1068

Met Leu Lys Ala Ala Ala Lys Arg Pro Glu Leu Ser Gly Leu Leu Lys 
1               5                   10                  15      


Phe Asn Asn Tyr Gly Ile Leu Ser Glu Ser Pro Leu Thr Ser Gln Arg 
            20                  25                  30          


Thr Thr Trp Leu Leu Tyr Gln Ser Pro Ser Phe Ile Pro Gly Phe Ala 
        35                  40                  45              


Tyr Pro Ser Arg Cys Leu Lys Thr Ile Gly Gly Val Tyr Lys Gln Ala 
    50                  55                  60                  


Arg Lys Lys His Tyr Ile Gln Gln Leu Arg Tyr Gly Arg Ser Glu Val 
65                  70                  75                  80  


Asn Val Pro Gly Ser Ser Ser Lys Ala Arg Ala Thr Val Cys Gly Arg 
                85                  90                  95      


Tyr Asn Asp Asn Gly Ala Val 
            100             


<210>  1069
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBOX1__Homo_sapiens__XP_011518705

<400>  1069

Met Ala Cys Thr Ile Gln Lys Ala Glu Ala Leu Asp Gly Ala His Leu 
1               5                   10                  15      


Met Gln Ile Leu Trp Tyr Asp Glu Glu Glu Ser Leu Tyr Pro Ala Val 
            20                  25                  30          


Trp Leu Arg Asp Asn Cys Pro Cys Ser Asp Cys Tyr Leu Asp Ser Ala 
        35                  40                  45              


Lys Ala Arg Lys Leu Leu Val Glu Ala Leu Asp Val Asn Ile Gly Ile 
    50                  55                  60                  


Lys Gly Leu Ile Phe Asp Arg Lys Lys Val Tyr Ile Thr Trp Pro Asp 
65                  70                  75                  80  


Glu His Tyr Ser Glu Phe Gln Ala Asp Trp Leu Lys Lys Arg Cys Phe 
                85                  90                  95      


Ser Lys Gln Ala Arg Ala Lys Leu Gln Arg Glu Leu Phe Phe Pro Glu 
            100                 105                 110         


Cys Gln Tyr Trp Gly Ser Glu Leu Gln Leu Pro Thr Leu Asp Phe Glu 
        115                 120                 125             


Asp Val Leu Arg Tyr Asp Glu His Ala Tyr Lys Trp Leu Ser Thr Leu 
    130                 135                 140                 


Lys Lys Val Gly Ile Val Arg Leu Thr Gly Ala Ser Asp Lys Pro Gly 
145                 150                 155                 160 


Glu Val Ser Lys Leu Gly Lys Arg Met Gly Phe Leu Tyr Leu Thr Phe 
                165                 170                 175     


Tyr Gly His Thr Trp Gln Val Gln Asp Lys Ile Asp Ala Asn Asn Val 
            180                 185                 190         


Ala Tyr Thr Thr Gly Lys Leu Ser Phe His Thr Asp Tyr Pro Ala Leu 
        195                 200                 205             


His His Pro Pro Gly Val Gln Leu Leu His Cys Ile Lys Gln Thr Val 
    210                 215                 220                 


Thr Gly Gly Asp Ser Glu Ile Val Asp Gly Phe Asn Val Cys Gln Lys 
225                 230                 235                 240 


Leu Lys Lys Asn Asn Pro Gln Ala Phe Gln Ile Leu Ser Ser Thr Phe 
                245                 250                 255     


Val Asp Phe Thr Asp Ile Gly Val Asp Tyr Cys Asp Phe Ser Val Gln 
            260                 265                 270         


Ser Lys His Lys Ile Ile Glu Leu Asp Asp Lys Gly Gln Val Val Arg 
        275                 280                 285             


Ile Asn Phe Asn Asn Ala Thr Arg Asp Thr Ile Phe Asp Val Pro Val 
    290                 295                 300                 


Glu Arg Val Gln Pro Phe Tyr Ala Ala Leu Lys Glu Phe Val Asp Leu 
305                 310                 315                 320 


Met Asn Ser Lys Glu Ser Lys Phe Thr Phe Lys Met Asn Pro Gly Asp 
                325                 330                 335     


Val Ile Thr Phe Asp Asn Trp Arg Leu Leu His Gly Arg Arg Ser Tyr 
            340                 345                 350         


Glu Ala Gly Thr Glu Ile Ser Arg His Leu Glu Gly Ala Tyr Ala Asp 
        355                 360                 365             


Trp Asp Val Val Met Ser Arg Leu Arg Ile Leu Arg Gln Arg Val Glu 
    370                 375                 380                 


Asn Gly Asn 
385         


<210>  1070
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS10__Homo_sapiens__NP_078961

<400>  1070

Met Leu Ser Ser Met Ala Ala Ala Gly Ser Val Lys Ala Ala Leu Gln 
1               5                   10                  15      


Val Ala Glu Val Leu Glu Ala Ile Val Ser Cys Cys Val Gly Pro Glu 
            20                  25                  30          


Gly Arg Gln Val Leu Cys Thr Lys Pro Thr Gly Glu Val Leu Leu Ser 
        35                  40                  45              


Arg Asn Gly Gly Arg Leu Leu Glu Ala Leu His Leu Glu His Pro Ile 
    50                  55                  60                  


Ala Arg Met Ile Val Asp Cys Val Ser Ser His Leu Lys Lys Thr Gly 
65                  70                  75                  80  


Asp Gly Ala Lys Thr Phe Ile Ile Phe Leu Cys His Leu Leu Arg Gly 
                85                  90                  95      


Leu His Ala Ile Thr Asp Arg Glu Lys Asp Pro Leu Met Cys Glu Asn 
            100                 105                 110         


Ile Gln Thr His Gly Arg His Trp Lys Asn Cys Ser Arg Trp Lys Phe 
        115                 120                 125             


Ile Ser Gln Ala Leu Leu Thr Phe Gln Thr Gln Ile Leu Asp Gly Ile 
    130                 135                 140                 


Met Asp Gln Tyr Leu Ser Arg His Phe Leu Ser Ile Phe Ser Ser Ala 
145                 150                 155                 160 


Lys Glu Arg Thr Leu Cys Arg Ser Ser Leu Glu Leu Leu Leu Glu Ala 
                165                 170                 175     


Tyr Phe Cys Gly Arg Val Gly Arg Asn Asn His Lys Phe Ile Ser Gln 
            180                 185                 190         


Leu Met Cys Asp Tyr Phe Phe Lys Cys Met Thr Cys Lys Ser Gly Ile 
        195                 200                 205             


Gly Val Phe Glu Leu Val Asp Asp His Phe Val Glu Leu Asn Val Gly 
    210                 215                 220                 


Val Thr Gly Leu Pro Val Ser Asp Ser Arg Ile Ile Ala Gly Leu Val 
225                 230                 235                 240 


Leu Gln Lys Asp Phe Ser Val Tyr Arg Pro Ala Asp Gly Asp Met Arg 
                245                 250                 255     


Met Val Ile Val Thr Glu Thr Ile Gln Pro Leu Phe Ser Thr Ser Gly 
            260                 265                 270         


Ser Glu Phe Ile Leu Asn Ser Glu Ala Gln Phe Gln Thr Ser Gln Phe 
        275                 280                 285             


Trp Ile Met Glu Lys Thr Lys Ala Ile Met Lys His Leu His Ser Gln 
    290                 295                 300                 


Asn Val Lys Leu Leu Ile Ser Ser Val Lys Gln Pro Asp Leu Val Ser 
305                 310                 315                 320 


Tyr Tyr Ala Gly Val Asn Gly Ile Ser Val Val Glu Cys Leu Ser Ser 
                325                 330                 335     


Glu Glu Val Ser Leu Ile Arg Arg Ile Ile Gly Leu Ser Pro Phe Val 
            340                 345                 350         


Pro Pro Gln Ala Phe Ser Gln Cys Glu Ile Pro Asn Thr Ala Leu Val 
        355                 360                 365             


Lys Phe Cys Lys Pro Leu Ile Leu Arg Ser Lys Arg Tyr Val His Leu 
    370                 375                 380                 


Gly Leu Ile Ser Thr Cys Ala Phe Ile Pro His Ser Ile Val Leu Cys 
385                 390                 395                 400 


Gly Pro Val His Gly Leu Ile Glu Gln His Glu Asp Ala Leu His Gly 
                405                 410                 415     


Ala Leu Lys Met Leu Arg Gln Leu Phe Lys Asp Leu Asp Leu Asn Tyr 
            420                 425                 430         


Met Thr Gln Thr Asn Asp Gln Asn Gly Thr Ser Ser Leu Phe Ile Tyr 
        435                 440                 445             


Lys Asn Ser Gly Glu Ser Tyr Gln Ala Pro Asp Pro Gly Asn Gly Ser 
    450                 455                 460                 


Ile Gln Arg Pro Tyr Gln Asp Thr Val Ala Glu Asn Lys Asp Ala Leu 
465                 470                 475                 480 


Glu Lys Thr Gln Thr Tyr Leu Lys Val His Ser Asn Leu Val Ile Pro 
                485                 490                 495     


Asp Val Glu Leu Glu Thr Tyr Ile Pro Tyr Ser Thr Pro Thr Leu Thr 
            500                 505                 510         


Pro Thr Asp Thr Phe Gln Thr Val Glu Thr Leu Thr Cys Leu Ser Leu 
        515                 520                 525             


Glu Arg Asn Arg Leu Thr Asp Tyr Tyr Glu Pro Leu Leu Lys Asn Asn 
    530                 535                 540                 


Ser Thr Ala Tyr Ser Thr Arg Gly Asn Arg Ile Glu Ile Ser Tyr Glu 
545                 550                 555                 560 


Asn Leu Gln Val Thr Asn Ile Thr Arg Lys Gly Ser Met Leu Pro Val 
                565                 570                 575     


Ser Cys Lys Leu Pro Asn Met Gly Thr Ser Gln Ser Tyr Leu Ser Ser 
            580                 585                 590         


Ser Met Pro Ala Gly Cys Val Leu Pro Val Gly Gly Asn Phe Glu Ile 
        595                 600                 605             


Leu Leu His Tyr Tyr Leu Leu Asn Tyr Ala Lys Lys Cys His Gln Ser 
    610                 615                 620                 


Glu Glu Thr Met Val Ser Met Ile Ile Ala Asn Ala Leu Leu Gly Ile 
625                 630                 635                 640 


Pro Lys Val Leu Tyr Lys Ser Lys Thr Gly Lys Tyr Ser Phe Pro His 
                645                 650                 655     


Thr Tyr Ile Arg Ala Val His Ala Leu Gln Thr Asn Gln Pro Leu Val 
            660                 665                 670         


Ser Ser Gln Thr Gly Leu Glu Ser Val Met Gly Lys Tyr Gln Leu Leu 
        675                 680                 685             


Thr Ser Val Leu Gln Cys Leu Thr Lys Ile Leu Thr Ile Asp Met Val 
    690                 695                 700                 


Ile Thr Val Lys Arg His Pro Gln Lys Val His Asn Gln Asp Ser Glu 
705                 710                 715                 720 


Asp Glu Leu 
            


<210>  1071
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS12__Homo_sapiens__NP_689831

<400>  1071

Met Val Met Ala Cys Arg Val Val Asn Lys Arg Arg His Met Gly Leu 
1               5                   10                  15      


Gln Gln Leu Ser Ser Phe Ala Glu Thr Gly Arg Thr Phe Leu Gly Pro 
            20                  25                  30          


Leu Lys Ser Ser Lys Phe Ile Ile Asp Glu Glu Cys His Glu Ser Val 
        35                  40                  45              


Leu Ile Ser Ser Thr Val Arg Leu Leu Glu Ser Leu Asp Leu Thr Ser 
    50                  55                  60                  


Ala Val Gly Gln Leu Leu Asn Glu Ala Val Gln Ala Gln Asn Asn Thr 
65                  70                  75                  80  


Tyr Arg Thr Gly Ile Ser Thr Leu Leu Phe Leu Val Gly Ala Trp Ser 
                85                  90                  95      


Ser Ala Val Glu Glu Cys Leu His Leu Gly Val Pro Ile Ser Ile Ile 
            100                 105                 110         


Val Ser Val Met Ser Glu Gly Leu Asn Phe Cys Ser Glu Glu Val Val 
        115                 120                 125             


Ser Leu His Val Pro Val His Asn Ile Phe Asp Cys Met Asp Ser Thr 
    130                 135                 140                 


Lys Thr Phe Ser Gln Leu Glu Thr Phe Ser Val Ser Leu Cys Pro Phe 
145                 150                 155                 160 


Leu Gln Val Pro Ser Asp Thr Asp Leu Ile Glu Glu Leu His Gly Leu 
                165                 170                 175     


Lys Asp Val Ala Ser Gln Thr Leu Thr Ile Ser Asn Leu Ser Gly Arg 
            180                 185                 190         


Pro Leu Lys Ser Tyr Glu Leu Phe Lys Pro Gln Thr Lys Val Glu Ala 
        195                 200                 205             


Asp Asn Asn Thr Ser Arg Thr Leu Lys Asn Ser Leu Leu Ala Asp Thr 
    210                 215                 220                 


Cys Cys Arg Gln Ser Ile Leu Ile His Ser Arg His Phe Asn Arg Thr 
225                 230                 235                 240 


Asp Asn Thr Glu Gly Val Ser Lys Pro Asp Gly Phe Gln Glu His Val 
                245                 250                 255     


Thr Ala Thr His Lys Thr Tyr Arg Cys Asn Asp Leu Val Glu Leu Ala 
            260                 265                 270         


Val Gly Leu Ser His Gly Asp His Ser Ser Met Lys Leu Val Glu Glu 
        275                 280                 285             


Ala Val Gln Leu Gln Tyr Gln Asn Ala Cys Val Gln Gln Gly Asn Cys 
    290                 295                 300                 


Thr Lys Pro Phe Met Phe Asp Ile Ser Arg Ile Phe Thr Cys Cys Leu 
305                 310                 315                 320 


Pro Gly Leu Pro Glu Thr Ser Ser Cys Val Cys Pro Gly Tyr Ile Thr 
                325                 330                 335     


Val Val Ser Val Ser Asn Asn Pro Val Ile Lys Glu Leu Gln Asn Gln 
            340                 345                 350         


Pro Val Arg Ile Val Leu Ile Glu Gly Asp Leu Thr Glu Asn Tyr Arg 
        355                 360                 365             


His Leu Gly Phe Asn Lys Ser Ala Asn Ile Lys Thr Val Leu Asp Ser 
    370                 375                 380                 


Met Arg Leu Gln Glu Asp Ser Ser Glu Glu Leu Trp Ala Asn His Val 
385                 390                 395                 400 


Leu Gln Val Leu Ile Gln Phe Lys Val Asn Leu Val Leu Val Gln Gly 
                405                 410                 415     


Asn Val Ser Glu Arg Leu Ile Glu Lys Cys Ile Asn Ser Lys Arg Leu 
            420                 425                 430         


Val Ile Gly Ser Val Asn Gly Ser Val Met Gln Ala Phe Ala Glu Ala 
        435                 440                 445             


Ala Gly Ala Val Gln Val Ala Tyr Ile Thr Gln Val Asn Glu Asp Cys 
    450                 455                 460                 


Val Gly Asp Gly Val Cys Val Thr Phe Trp Arg Ser Ser Pro Leu Asp 
465                 470                 475                 480 


Val Val Asp Arg Asn Asn Arg Ile Ala Ile Leu Leu Lys Thr Glu Gly 
                485                 490                 495     


Ile Asn Leu Val Thr Ala Val Leu Thr Asn Pro Val Thr Ala Gln Met 
            500                 505                 510         


Gln Ile Lys Glu Asp Arg Phe Trp Thr Cys Ala Tyr Arg Leu Tyr Tyr 
        515                 520                 525             


Ala Leu Lys Glu Glu Lys Val Phe Leu Gly Gly Gly Ala Val Glu Phe 
    530                 535                 540                 


Leu Cys Leu Ser Cys Leu His Ile Leu Ala Glu Gln Ser Leu Lys Lys 
545                 550                 555                 560 


Glu Asn His Ala Cys Ser Gly Trp Leu His Asn Thr Ser Ser Trp Leu 
                565                 570                 575     


Ala Ser Ser Leu Ala Ile Tyr Arg Pro Thr Val Leu Lys Phe Leu Ala 
            580                 585                 590         


Asn Gly Trp Gln Lys Tyr Leu Ser Thr Leu Leu Tyr Asn Thr Ala Asn 
        595                 600                 605             


Tyr Ser Ser Glu Phe Glu Ala Ser Thr Tyr Ile Gln His His Leu Gln 
    610                 615                 620                 


Asn Ala Thr Asp Ser Gly Ser Pro Ser Ser Tyr Ile Leu Asn Glu Tyr 
625                 630                 635                 640 


Ser Lys Leu Asn Ser Arg Ile Phe Asn Ser Asp Ile Ser Asn Lys Leu 
                645                 650                 655     


Glu Gln Ile Pro Arg Val Tyr Asp Val Val Thr Pro Lys Ile Glu Ala 
            660                 665                 670         


Trp Arg Arg Ala Leu Asp Leu Val Leu Leu Val Leu Gln Thr Asp Ser 
        675                 680                 685             


Glu Ile Ile Thr Gly His Gly His Thr Gln Ile Asn Ser Gln Glu Leu 
    690                 695                 700                 


Thr Gly Phe Leu Phe Leu 
705                 710 


<210>  1072
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS1__Homo_sapiens__NP_078925

<400>  1072

Met Ala Ala Ala Ser Ser Ser Asp Ser Asp Ala Cys Gly Ala Glu Ser 
1               5                   10                  15      


Asn Glu Ala Asn Ser Lys Trp Leu Asp Ala His Tyr Asp Pro Met Ala 
            20                  25                  30          


Asn Ile His Thr Phe Ser Ala Cys Leu Ala Leu Ala Asp Leu His Gly 
        35                  40                  45              


Asp Gly Glu Tyr Lys Leu Val Val Gly Asp Leu Gly Pro Gly Gly Gln 
    50                  55                  60                  


Gln Pro Arg Leu Lys Val Leu Lys Gly Pro Leu Val Met Thr Glu Ser 
65                  70                  75                  80  


Pro Leu Pro Ala Leu Pro Ala Ala Ala Ala Thr Phe Leu Met Glu Gln 
                85                  90                  95      


His Glu Pro Arg Thr Pro Ala Leu Ala Leu Ala Ser Gly Pro Cys Val 
            100                 105                 110         


Tyr Val Tyr Lys Asn Leu Arg Pro Tyr Phe Lys Phe Ser Leu Pro Gln 
        115                 120                 125             


Leu Pro Pro Asn Pro Leu Glu Gln Asp Leu Trp Asn Gln Ala Lys Glu 
    130                 135                 140                 


Asp Arg Ile Asp Pro Leu Thr Leu Lys Glu Met Leu Glu Ser Ile Arg 
145                 150                 155                 160 


Glu Thr Ala Glu Glu Pro Leu Ser Ile Gln Ser Leu Arg Phe Leu Gln 
                165                 170                 175     


Leu Glu Leu Ser Glu Met Glu Ala Phe Val Asn Gln His Lys Ser Asn 
            180                 185                 190         


Ser Ile Lys Arg Gln Thr Val Ile Thr Thr Met Thr Thr Leu Lys Lys 
        195                 200                 205             


Asn Leu Ala Asp Glu Asp Ala Val Ser Cys Leu Val Leu Gly Thr Glu 
    210                 215                 220                 


Asn Lys Glu Leu Leu Val Leu Asp Pro Glu Ala Phe Thr Ile Leu Ala 
225                 230                 235                 240 


Lys Met Ser Leu Pro Ser Val Pro Val Phe Leu Glu Val Ser Gly Gln 
                245                 250                 255     


Phe Asp Val Glu Phe Arg Leu Ala Ala Ala Cys Arg Asn Gly Asn Ile 
            260                 265                 270         


Tyr Ile Leu Arg Arg Asp Ser Lys His Pro Lys Tyr Cys Ile Glu Leu 
        275                 280                 285             


Ser Ala Gln Pro Val Gly Leu Ile Arg Val His Lys Val Leu Val Val 
    290                 295                 300                 


Gly Ser Thr Gln Asp Ser Leu His Gly Phe Thr His Lys Gly Lys Lys 
305                 310                 315                 320 


Leu Trp Thr Val Gln Met Pro Ala Ala Ile Leu Thr Met Asn Leu Leu 
                325                 330                 335     


Glu Gln His Ser Arg Gly Leu Gln Ala Val Met Ala Gly Leu Ala Asn 
            340                 345                 350         


Gly Glu Val Arg Ile Tyr Arg Asp Lys Ala Leu Leu Asn Val Ile His 
        355                 360                 365             


Thr Pro Asp Ala Val Thr Ser Leu Cys Phe Gly Arg Tyr Gly Arg Glu 
    370                 375                 380                 


Asp Asn Thr Leu Ile Met Thr Thr Arg Gly Gly Gly Leu Ile Ile Lys 
385                 390                 395                 400 


Ile Leu Lys Arg Thr Ala Val Phe Val Glu Gly Gly Ser Glu Val Gly 
                405                 410                 415     


Pro Pro Pro Ala Gln Ala Met Lys Leu Asn Val Pro Arg Lys Thr Arg 
            420                 425                 430         


Leu Tyr Val Asp Gln Thr Leu Arg Glu Arg Glu Ala Gly Thr Ala Met 
        435                 440                 445             


His Arg Ala Phe Gln Thr Asp Leu Tyr Leu Leu Arg Leu Arg Ala Ala 
    450                 455                 460                 


Arg Ala Tyr Leu Gln Ala Leu Glu Ser Ser Leu Ser Pro Leu Ser Thr 
465                 470                 475                 480 


Thr Ala Arg Glu Pro Leu Lys Leu His Ala Val Val Gln Gly Leu Gly 
                485                 490                 495     


Pro Thr Phe Lys Leu Thr Leu His Leu Gln Asn Thr Ser Thr Thr Arg 
            500                 505                 510         


Pro Val Leu Gly Leu Leu Val Cys Phe Leu Tyr Asn Glu Ala Leu Tyr 
        515                 520                 525             


Ser Leu Pro Arg Ala Phe Phe Lys Val Pro Leu Leu Val Pro Gly Leu 
    530                 535                 540                 


Asn Tyr Pro Leu Glu Thr Phe Val Glu Ser Leu Ser Asn Lys Gly Ile 
545                 550                 555                 560 


Ser Asp Ile Ile Lys Val Leu Val Leu Arg Glu Gly Gln Ser Ala Pro 
                565                 570                 575     


Leu Leu Ser Ala His Val Asn Met Pro Gly Ser Glu Gly Leu Ala Ala 
            580                 585                 590         


Ala 
    


<210>  1073
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS2__Homo_sapiens__XP_005256137

<400>  1073

Met Leu Leu Pro Val Phe Thr Leu Lys Leu Arg His Lys Ile Ser Pro 
1               5                   10                  15      


Arg Met Val Ala Ile Gly Arg Tyr Asp Gly Thr His Pro Cys Leu Ala 
            20                  25                  30          


Ala Ala Thr Gln Thr Gly Lys Val Phe Ile His Asn Pro His Thr Arg 
        35                  40                  45              


Asn Gln His Val Ser Ala Ser Arg Val Phe Gln Ser Pro Leu Glu Ser 
    50                  55                  60                  


Asp Val Ser Leu Leu Ser Ile Asn Gln Ala Val Ser Cys Leu Thr Ala 
65                  70                  75                  80  


Gly Val Leu Asn Pro Glu Leu Gly Tyr Asp Ala Leu Leu Val Gly Thr 
                85                  90                  95      


Gln Thr Asn Leu Leu Ala Tyr Asp Val Tyr Asn Asn Ser Asp Leu Phe 
            100                 105                 110         


Tyr Arg Glu Val Ala Asp Gly Ala Asn Ala Ile Val Leu Gly Thr Leu 
        115                 120                 125             


Gly Asp Ile Ser Ser Pro Leu Ala Ile Ile Gly Gly Asn Cys Ala Leu 
    130                 135                 140                 


Gln Gly Phe Asn His Glu Gly Ser Asp Leu Phe Trp Thr Val Thr Gly 
145                 150                 155                 160 


Asp Asn Val Asn Ser Leu Ala Leu Cys Asp Phe Asp Gly Asp Gly Lys 
                165                 170                 175     


Lys Glu Leu Leu Val Gly Ser Glu Asp Phe Asp Ile Arg Val Phe Lys 
            180                 185                 190         


Glu Asp Glu Ile Val Ala Glu Met Thr Glu Thr Glu Ile Val Thr Ser 
        195                 200                 205             


Leu Cys Pro Met Tyr Gly Ser Arg Phe Gly Tyr Ala Leu Ser Asn Gly 
    210                 215                 220                 


Thr Val Gly Val Tyr Asp Lys Thr Ser Arg Tyr Trp Arg Ile Lys Ser 
225                 230                 235                 240 


Lys Asn His Ala Met Ser Ile His Ala Phe Asp Leu Asn Ser Asp Gly 
                245                 250                 255     


Val Asn Glu Leu Ile Thr Gly Trp Ser Asn Gly Lys Val Asp Ala Arg 
            260                 265                 270         


Ser Asp Arg Thr Gly Glu Val Ile Phe Lys Asp Asn Phe Ser Ser Ala 
        275                 280                 285             


Ile Ala Gly Val Val Glu Gly Asp Tyr Arg Met Asp Gly His Ile Gln 
    290                 295                 300                 


Leu Ile Cys Cys Ser Val Asp Gly Glu Ile Arg Gly Tyr Leu Pro Gly 
305                 310                 315                 320 


Thr Ala Glu Met Arg Gly Asn Leu Met Asp Thr Ser Ala Glu Gln Asp 
                325                 330                 335     


Leu Ile Arg Glu Leu Ser Gln Lys Lys Gln Asn Leu Leu Leu Glu Leu 
            340                 345                 350         


Arg Asn Tyr Glu Glu Asn Ala Lys Ala Glu Leu Ala Ser Pro Leu Asn 
        355                 360                 365             


Glu Ala Asp Gly His Arg Gly Ile Ile Pro Ala Asn Thr Arg Leu His 
    370                 375                 380                 


Thr Thr Leu Ser Val Ser Leu Gly Asn Glu Thr Gln Thr Ala His Thr 
385                 390                 395                 400 


Glu Leu Arg Ile Ser Thr Ser Asn Asp Thr Ile Ile Arg Ala Val Leu 
                405                 410                 415     


Ile Phe Ala Glu Gly Ile Phe Thr Gly Glu Ser His Val Val His Pro 
            420                 425                 430         


Ser Ile His Asn Leu Ser Ser Ser Ile Cys Ile Pro Ile Val Pro Pro 
        435                 440                 445             


Lys Asp Val Pro Val Asp Leu His Leu Lys Ala Phe Val Gly Tyr Arg 
    450                 455                 460                 


Ser Ser Thr Gln Phe His Val Phe Glu Ser Thr Arg Gln Leu Pro Arg 
465                 470                 475                 480 


Phe Ser Met Tyr Ala Leu Thr Ser Leu Asp Pro Ala Ser Glu Pro Ile 
                485                 490                 495     


Ser Tyr Val Asn Phe Thr Ile Ala Glu Arg Ala Gln Arg Val Val Val 
            500                 505                 510         


Trp Leu Gly Gln Asn Phe Leu Leu Pro Glu Asp Thr His Ile Gln Asn 
        515                 520                 525             


Ala Pro Phe Gln Val Cys Phe Thr Ser Leu Arg Asn Gly Gly His Leu 
    530                 535                 540                 


His Ile Lys Ile Lys Leu Ser Gly Glu Ile Thr Ile Asn Thr Asp Asp 
545                 550                 555                 560 


Ile Asp Leu Ala Gly Asp Ile Ile Gln Ser Met Ala Ser Phe Phe Ala 
                565                 570                 575     


Ile Glu Asp Leu Gln Val Glu Ala Asp Phe Pro Val Tyr Phe Glu Glu 
            580                 585                 590         


Leu Arg Lys Val Leu Val Lys Val Asp Glu Tyr His Ser Val His Gln 
        595                 600                 605             


Lys Leu Ser Ala Asp Met Ala Asp His Ser Asn Leu Ile Arg Ser Leu 
    610                 615                 620                 


Leu Val Gly Ala Glu Asp Ala Arg Leu Met Arg Asp Met Lys Thr Met 
625                 630                 635                 640 


Lys Ser Arg Tyr Met Glu Leu Tyr Asp Leu Asn Arg Asp Leu Leu Asn 
                645                 650                 655     


Gly Tyr Lys Ile Arg Cys Asn Asn His Thr Glu Leu Leu Gly Asn Leu 
            660                 665                 670         


Lys Ala Val Asn Gln Ala Ile Gln Arg Ala Gly Arg Leu Arg Val Gly 
        675                 680                 685             


Lys Pro Lys Asn Gln Val Ile Thr Ala Cys Arg Asp Ala Ile Arg Ser 
    690                 695                 700                 


Asn Asn Ile Asn Thr Leu Phe Lys Ile Met Arg Val Gly Thr Ala Ser 
705                 710                 715                 720 


Ser 
    


<210>  1074
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS4__Homo_sapiens__NP_149017

<400>  1074

Met Ala Glu Glu Arg Val Ala Thr Arg Thr Gln Phe Pro Val Ser Thr 
1               5                   10                  15      


Glu Ser Gln Lys Pro Arg Gln Lys Lys Ala Pro Glu Phe Pro Ile Leu 
            20                  25                  30          


Glu Lys Gln Asn Trp Leu Ile His Leu His Tyr Ile Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ala Cys Lys Ala Val Ile Lys Glu Gln Leu Gln Glu Thr Gln Gly 
    50                  55                  60                  


Leu Cys Glu Tyr Ala Ile Tyr Val Gln Ala Leu Ile Phe Arg Leu Glu 
65                  70                  75                  80  


Gly Asn Ile Gln Glu Ser Leu Glu Leu Phe Gln Thr Cys Ala Val Leu 
                85                  90                  95      


Ser Pro Gln Ser Ala Asp Asn Leu Lys Gln Val Ala Arg Ser Leu Phe 
            100                 105                 110         


Leu Leu Gly Lys His Lys Ala Ala Ile Glu Val Tyr Asn Glu Ala Ala 
        115                 120                 125             


Lys Leu Asn Gln Lys Asp Trp Glu Ile Ser His Asn Leu Gly Val Cys 
    130                 135                 140                 


Tyr Ile Tyr Leu Lys Gln Phe Asn Lys Ala Gln Asp Gln Leu His Asn 
145                 150                 155                 160 


Ala Leu Asn Leu Asn Arg His Asp Leu Thr Tyr Ile Met Leu Gly Lys 
                165                 170                 175     


Ile His Leu Leu Glu Gly Asp Leu Asp Lys Ala Ile Glu Val Tyr Lys 
            180                 185                 190         


Lys Ala Val Glu Phe Ser Pro Glu Asn Thr Glu Leu Leu Thr Thr Leu 
        195                 200                 205             


Gly Leu Leu Tyr Leu Gln Leu Gly Ile Tyr Gln Lys Ala Phe Glu His 
    210                 215                 220                 


Leu Gly Asn Ala Leu Thr Tyr Asp Pro Thr Asn Tyr Lys Ala Ile Leu 
225                 230                 235                 240 


Ala Ala Gly Ser Met Met Gln Thr His Gly Asp Phe Asp Val Ala Leu 
                245                 250                 255     


Thr Lys Tyr Arg Val Val Ala Cys Ala Val Pro Glu Ser Pro Pro Leu 
            260                 265                 270         


Trp Asn Asn Ile Gly Met Cys Phe Phe Gly Lys Lys Lys Tyr Val Ala 
        275                 280                 285             


Ala Ile Ser Cys Leu Lys Arg Ala Asn Tyr Leu Ala Pro Phe Asp Trp 
    290                 295                 300                 


Lys Ile Leu Tyr Asn Leu Gly Leu Val His Leu Thr Met Gln Gln Tyr 
305                 310                 315                 320 


Ala Ser Ala Phe His Phe Leu Ser Ala Ala Ile Asn Phe Gln Pro Lys 
                325                 330                 335     


Met Gly Glu Leu Tyr Met Leu Leu Ala Val Ala Leu Thr Asn Leu Glu 
            340                 345                 350         


Asp Ile Glu Asn Ala Lys Arg Ala Tyr Ala Glu Ala Val His Leu Asp 
        355                 360                 365             


Lys Cys Asn Pro Leu Val Asn Leu Asn Tyr Ala Val Leu Leu Tyr Asn 
    370                 375                 380                 


Gln Gly Glu Lys Lys Asn Ala Leu Ala Gln Tyr Gln Glu Met Glu Lys 
385                 390                 395                 400 


Lys Val Ser Leu Leu Lys Asp Asn Ser Ser Leu Glu Phe Asp Ser Glu 
                405                 410                 415     


Met Val Glu Met Ala Gln Lys Leu Gly Ala Ala Leu Gln Val Gly Glu 
            420                 425                 430         


Ala Leu Val Trp Thr Lys Pro Val Lys Asp Pro Lys Ser Lys His Gln 
        435                 440                 445             


Thr Thr Ser Thr Ser Lys Pro Ala Ser Phe Gln Gln Pro Leu Gly Ser 
    450                 455                 460                 


Asn Gln Ala Leu Gly Gln Ala Met Ser Ser Ala Ala Ala Tyr Arg Thr 
465                 470                 475                 480 


Leu Pro Ser Gly Ala Gly Gly Thr Ser Gln Phe Thr Lys Pro Pro Ser 
                485                 490                 495     


Leu Pro Leu Glu Pro Glu Pro Ala Val Glu Ser Ser Pro Thr Glu Thr 
            500                 505                 510         


Ser Glu Gln Ile Arg Glu Lys 
        515                 


<210>  1075
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS5__Homo_sapiens__NP_689597

<400>  1075

Met Ser Val Leu Asp Ala Leu Trp Glu Asp Arg Asp Val Arg Phe Asp 
1               5                   10                  15      


Leu Ser Ala Gln Gln Met Lys Thr Arg Pro Gly Glu Val Leu Ile Asp 
            20                  25                  30          


Cys Leu Asp Ser Ile Glu Asp Thr Lys Gly Asn Asn Gly Asp Arg Gly 
        35                  40                  45              


Arg Leu Leu Val Thr Asn Leu Arg Ile Leu Trp His Ser Leu Ala Leu 
    50                  55                  60                  


Ser Arg Val Asn Val Ser Val Gly Tyr Asn Cys Ile Leu Asn Ile Thr 
65                  70                  75                  80  


Thr Arg Thr Ala Asn Ser Lys Leu Arg Gly Gln Thr Glu Ala Leu Tyr 
                85                  90                  95      


Ile Leu Thr Lys Cys Asn Ser Thr Arg Phe Glu Phe Ile Phe Thr Asn 
            100                 105                 110         


Leu Val Pro Gly Ser Pro Arg Leu Phe Thr Ser Val Met Ala Val His 
        115                 120                 125             


Arg Ala Tyr Glu Thr Ser Lys Met Tyr Arg Asp Phe Lys Leu Arg Ser 
    130                 135                 140                 


Ala Leu Ile Gln Asn Lys Gln Leu Arg Leu Leu Pro Gln Glu His Val 
145                 150                 155                 160 


Tyr Asp Lys Ile Asn Gly Val Trp Asn Leu Ser Ser Asp Gln Gly Asn 
                165                 170                 175     


Leu Gly Thr Phe Phe Ile Thr Asn Val Arg Ile Val Trp His Ala Asn 
            180                 185                 190         


Met Asn Asp Ser Phe Asn Val Ser Ile Pro Tyr Leu Gln Ile Arg Ser 
        195                 200                 205             


Ile Lys Ile Arg Asp Ser Lys Phe Gly Leu Ala Leu Val Ile Glu Ser 
    210                 215                 220                 


Ser Gln Gln Ser Gly Gly Tyr Val Leu Gly Phe Lys Ile Asp Pro Val 
225                 230                 235                 240 


Glu Lys Leu Gln Glu Ser Val Lys Glu Ile Asn Ser Leu His Lys Val 
                245                 250                 255     


Tyr Ser Ala Ser Pro Ile Phe Gly Val Asp Tyr Glu Met Glu Glu Lys 
            260                 265                 270         


Pro Gln Pro Leu Glu Ala Leu Thr Val Glu Gln Ile Gln Asp Asp Val 
        275                 280                 285             


Glu Ile Asp Ser Asp Gly His Thr Asp Ala Phe Val Ala Tyr Phe Ala 
    290                 295                 300                 


Asp Gly Asn Lys Gln Gln Asp Arg Glu Pro Val Phe Ser Glu Glu Leu 
305                 310                 315                 320 


Gly Leu Ala Ile Glu Lys Leu Lys Asp Gly Phe Thr Leu Gln Gly Leu 
                325                 330                 335     


Trp Glu Val Met Ser 
            340     


<210>  1076
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS7__Homo_sapiens__NP_060660

<400>  1076

Met Asp Leu Ile Leu Asn Arg Met Asp Tyr Leu Gln Val Gly Val Thr 
1               5                   10                  15      


Ser Gln Lys Thr Met Lys Leu Ile Pro Ala Ser Arg His Arg Ala Thr 
            20                  25                  30          


Gln Lys Val Val Ile Gly Asp His Asp Gly Val Val Met Cys Phe Gly 
        35                  40                  45              


Met Lys Lys Gly Glu Ala Ala Ala Val Phe Lys Thr Leu Pro Gly Pro 
    50                  55                  60                  


Lys Ile Ala Arg Leu Glu Leu Gly Gly Val Ile Asn Thr Pro Gln Glu 
65                  70                  75                  80  


Lys Ile Phe Ile Ala Ala Ala Ser Glu Ile Arg Gly Phe Thr Lys Arg 
                85                  90                  95      


Gly Lys Gln Phe Leu Ser Phe Glu Thr Asn Leu Thr Glu Ser Ile Lys 
            100                 105                 110         


Ala Met His Ile Ser Gly Ser Asp Leu Phe Leu Ser Ala Ser Tyr Ile 
        115                 120                 125             


Tyr Asn His Tyr Cys Asp Cys Lys Asp Gln His Tyr Tyr Leu Ser Gly 
    130                 135                 140                 


Asp Lys Ile Asn Asp Val Ile Cys Leu Pro Val Glu Arg Leu Ser Arg 
145                 150                 155                 160 


Ile Thr Pro Val Leu Ala Cys Gln Asp Arg Val Leu Arg Val Leu Gln 
                165                 170                 175     


Gly Ser Asp Val Met Tyr Ala Val Glu Val Pro Gly Pro Pro Thr Val 
            180                 185                 190         


Leu Ala Leu His Asn Gly Asn Gly Gly Asp Ser Gly Glu Asp Leu Leu 
        195                 200                 205             


Phe Gly Thr Ser Asp Gly Lys Leu Ala Leu Ile Gln Ile Thr Thr Ser 
    210                 215                 220                 


Lys Pro Val Arg Lys Trp Glu Ile Gln Asn Glu Lys Lys Arg Gly Gly 
225                 230                 235                 240 


Ile Leu Cys Ile Asp Ser Phe Asp Ile Val Gly Asp Gly Val Lys Asp 
                245                 250                 255     


Leu Leu Val Gly Arg Asp Asp Gly Met Val Glu Val Tyr Ser Phe Asp 
            260                 265                 270         


Asn Ala Asn Glu Pro Val Leu Arg Phe Asp Gln Met Leu Ser Glu Ser 
        275                 280                 285             


Val Thr Ser Ile Gln Gly Gly Cys Val Gly Lys Asp Ser Tyr Asp Glu 
    290                 295                 300                 


Ile Val Val Ser Thr Tyr Ser Gly Trp Val Thr Gly Leu Thr Thr Glu 
305                 310                 315                 320 


Pro Ile His Lys Glu Ser Gly Pro Gly Glu Glu Leu Lys Ile Asn Gln 
                325                 330                 335     


Glu Met Gln Asn Lys Ile Ser Ser Leu Arg Asn Glu Leu Glu His Leu 
            340                 345                 350         


Gln Tyr Lys Val Leu Gln Glu Arg Glu Asn Tyr Gln Gln Ser Ser Gln 
        355                 360                 365             


Ser Ser Lys Ala Lys Ser Ala Val Pro Ser Phe Gly Ile Asn Asp Lys 
    370                 375                 380                 


Phe Thr Leu Asn Lys Asp Asp Ala Ser Tyr Ser Leu Ile Leu Glu Val 
385                 390                 395                 400 


Gln Thr Ala Ile Asp Asn Val Leu Ile Gln Ser Asp Val Pro Ile Asp 
                405                 410                 415     


Leu Leu Asp Val Asp Lys Asn Ser Ala Val Val Ser Phe Ser Ser Cys 
            420                 425                 430         


Asp Ser Glu Ser Asn Asp Asn Phe Leu Leu Ala Thr Tyr Arg Cys Gln 
        435                 440                 445             


Ala Asp Thr Thr Arg Leu Glu Leu Lys Ile Arg Ser Ile Glu Gly Gln 
    450                 455                 460                 


Tyr Gly Thr Leu Gln Ala Tyr Val Thr Pro Arg Ile Gln Pro Lys Thr 
465                 470                 475                 480 


Cys Gln Val Arg Gln Tyr His Ile Lys Pro Leu Ser Leu His Gln Arg 
                485                 490                 495     


Thr His Phe Ile Asp His Asp Arg Pro Met Asn Thr Leu Thr Leu Thr 
            500                 505                 510         


Gly Gln Phe Ser Phe Ala Glu Val His Ser Trp Val Val Phe Cys Leu 
        515                 520                 525             


Pro Glu Val Pro Glu Lys Pro Pro Ala Gly Glu Cys Val Thr Phe Tyr 
    530                 535                 540                 


Phe Gln Asn Thr Phe Leu Asp Thr Gln Leu Glu Ser Thr Tyr Arg Lys 
545                 550                 555                 560 


Gly Glu Gly Val Phe Lys Ser Asp Asn Ile Ser Thr Ile Ser Ile Leu 
                565                 570                 575     


Lys Asp Val Leu Ser Lys Glu Ala Thr Lys Arg Lys Ile Asn Leu Asn 
            580                 585                 590         


Ile Ser Tyr Glu Ile Asn Glu Val Ser Val Lys His Thr Leu Lys Leu 
        595                 600                 605             


Ile His Pro Lys Leu Glu Tyr Gln Leu Leu Leu Ala Lys Lys Val Gln 
    610                 615                 620                 


Leu Ile Asp Ala Leu Lys Glu Leu Gln Ile His Glu Gly Asn Thr Asn 
625                 630                 635                 640 


Phe Leu Ile Pro Glu Tyr His Cys Ile Leu Glu Glu Ala Asp His Leu 
                645                 650                 655     


Gln Glu Glu Tyr Lys Lys Gln Pro Ala His Leu Glu Arg Leu Tyr Gly 
            660                 665                 670         


<210>  1077
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBS9__Homo_sapiens__NP_001028776

<400>  1077

Met Ser Leu Phe Lys Ala Arg Asp Trp Trp Ser Thr Ile Leu Gly Asp 
1               5                   10                  15      


Lys Glu Glu Phe Asp Gln Gly Cys Leu Cys Leu Ala Asn Val Asp Asn 
            20                  25                  30          


Ser Gly Asn Gly Gln Asp Lys Ile Ile Val Gly Ser Phe Met Gly Tyr 
        35                  40                  45              


Leu Arg Ile Phe Ser Pro His Pro Ala Lys Thr Gly Asp Gly Ala Gln 
    50                  55                  60                  


Ala Glu Asp Leu Leu Leu Glu Val Asp Leu Arg Asp Pro Val Leu Gln 
65                  70                  75                  80  


Val Glu Val Gly Lys Phe Val Ser Gly Thr Glu Met Leu His Leu Ala 
                85                  90                  95      


Val Leu His Ser Arg Lys Leu Cys Val Tyr Ser Val Ser Gly Thr Leu 
            100                 105                 110         


Gly Asn Val Glu His Gly Asn Gln Cys Gln Met Lys Leu Met Tyr Glu 
        115                 120                 125             


His Asn Leu Gln Arg Thr Ala Cys Asn Met Thr Tyr Gly Ser Phe Gly 
    130                 135                 140                 


Gly Val Lys Gly Arg Asp Leu Ile Cys Ile Gln Ser Met Asp Gly Met 
145                 150                 155                 160 


Leu Met Val Phe Glu Gln Glu Ser Tyr Ala Phe Gly Arg Phe Leu Pro 
                165                 170                 175     


Gly Phe Leu Leu Pro Gly Pro Leu Ala Tyr Ser Ser Arg Thr Asp Ser 
            180                 185                 190         


Phe Leu Thr Val Ser Ser Cys Gln Gln Val Glu Ser Tyr Lys Tyr Gln 
        195                 200                 205             


Val Leu Ala Phe Ala Thr Asp Ala Asp Lys Arg Gln Glu Thr Glu Gln 
    210                 215                 220                 


Gln Lys Leu Gly Ser Gly Lys Arg Leu Val Val Asp Trp Thr Leu Asn 
225                 230                 235                 240 


Ile Gly Glu Gln Ala Leu Asp Ile Cys Ile Val Ser Phe Asn Gln Ser 
                245                 250                 255     


Ala Ser Ser Val Phe Val Leu Gly Glu Arg Asn Phe Phe Cys Leu Lys 
            260                 265                 270         


Asp Asn Gly Gln Ile Arg Phe Met Lys Lys Leu Asp Trp Ser Pro Ser 
        275                 280                 285             


Cys Phe Leu Pro Tyr Cys Ser Val Ser Glu Gly Thr Ile Asn Thr Leu 
    290                 295                 300                 


Ile Gly Asn His Asn Asn Met Leu His Ile Tyr Gln Asp Val Thr Leu 
305                 310                 315                 320 


Lys Trp Ala Thr Gln Leu Pro His Ile Pro Val Ala Val Arg Val Gly 
                325                 330                 335     


Cys Leu His Asp Leu Lys Gly Val Ile Val Thr Leu Ser Asp Asp Gly 
            340                 345                 350         


His Leu Gln Cys Ser Tyr Leu Gly Thr Asp Pro Ser Leu Phe Gln Ala 
        355                 360                 365             


Pro Asn Val Gln Ser Arg Glu Leu Asn Tyr Asp Glu Leu Asp Val Glu 
    370                 375                 380                 


Met Lys Glu Leu Gln Lys Ile Ile Lys Asp Val Asn Lys Ser Gln Gly 
385                 390                 395                 400 


Val Trp Pro Met Thr Glu Arg Glu Asp Asp Leu Asn Val Ser Val Val 
                405                 410                 415     


Val Ser Pro Asn Phe Asp Ser Val Ser Gln Ala Thr Asp Val Glu Val 
            420                 425                 430         


Gly Thr Asp Leu Val Pro Ser Val Thr Val Lys Val Thr Leu Gln Asn 
        435                 440                 445             


Arg Val Ile Leu Gln Lys Ala Lys Leu Ser Val Tyr Val Gln Pro Pro 
    450                 455                 460                 


Leu Glu Leu Thr Cys Asp Gln Phe Thr Phe Glu Phe Met Asn Arg Asn 
465                 470                 475                 480 


Pro Asp Gly Ile Pro Arg Val Ile Gln Cys Lys Phe Arg Leu Pro Leu 
                485                 490                 495     


Lys Leu Ile Cys Leu Pro Gly Gln Pro Ser Lys Thr Ala Ser His Lys 
            500                 505                 510         


Ile Thr Ile Asp Thr Asn Lys Ser Pro Val Ser Leu Leu Ser Leu Phe 
        515                 520                 525             


Pro Gly Phe Ala Ser Gln Ser Asp Asp Asp Gln Val Asn Val Met Gly 
    530                 535                 540                 


Phe His Phe Leu Gly Gly Ala Arg Ile Thr Val Leu Ala Ser Lys Thr 
545                 550                 555                 560 


Ser Gln Arg Tyr Arg Ile Gln Ser Glu Gln Phe Glu Asp Leu Trp Leu 
                565                 570                 575     


Ile Thr Asn Glu Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu Lys Gln 
            580                 585                 590         


Gly Val Lys Asp Phe Ala Cys Ser Phe Ser Gly Ser Ile Pro Leu Gln 
        595                 600                 605             


Glu Tyr Phe Glu Leu Ile Asp His His Phe Glu Leu Arg Ile Asn Gly 
    610                 615                 620                 


Glu Lys Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln Phe Arg Ala 
625                 630                 635                 640 


Ile Gln Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro Ala Pro 
                645                 650                 655     


Leu Gln His Leu Asp Thr Leu Leu Asp Gly Thr Tyr Lys Gln Val Ile 
            660                 665                 670         


Ala Leu Ala Asp Ala Val Glu Glu Asn Gln Gly Asn Leu Phe Gln Ser 
        675                 680                 685             


Phe Thr Arg Leu Lys Ser Ala Thr His Leu Val Ile Leu Leu Ile Ala 
    690                 695                 700                 


Leu Trp Gln Lys Leu Ser Ala Asp Gln Val Ala Ile Leu Glu Ala Ala 
705                 710                 715                 720 


Phe Leu Pro Leu Gln Glu Asp Thr Gln Glu Leu Gly Trp Glu Glu Thr 
                725                 730                 735     


Val Asp Ala Ala Ile Ser His Leu Leu Lys Thr Cys Leu Ser Lys Ser 
            740                 745                 750         


Ser Lys Glu Gln Ala Leu Asn Leu Asn Ser Gln Leu Asn Ile Pro Lys 
        755                 760                 765             


Asp Thr Ser Gln Leu Lys Lys His Ile Thr Leu Leu Cys Asp Arg Leu 
    770                 775                 780                 


Ser Lys Gly Gly Arg Leu Cys Leu Ser Thr Asp Ala Ala Ala Pro Gln 
785                 790                 795                 800 


Thr Met Val Met Pro Gly Gly Cys Thr Thr Ile Pro Glu Ser Asp Leu 
                805                 810                 815     


Glu Glu Arg Ser Val Glu Gln Asp Ser Thr Glu Leu Phe Thr Asn His 
            820                 825                 830         


Arg His Leu Thr Ala Glu Thr Pro Arg Pro Glu Val Ser Pro Leu Gln 
        835                 840                 845             


Gly Val Ser Glu 
    850         


<210>  1078
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBX__Homo_sapiens__NP_001136040

<400>  1078

Met Lys Gly Ser Asn Arg Asn Lys Asp His Ser Ala Glu Gly Glu Gly 
1               5                   10                  15      


Val Gly Lys Arg Pro Lys Arg Lys Cys Leu Gln Trp His Pro Leu Leu 
            20                  25                  30          


Ala Lys Lys Leu Leu Asp Phe Ser Glu Glu Glu Glu Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Asp Ile Asp Lys Val Gln Leu Leu Gly Ala Asp Gly Leu Glu 
    50                  55                  60                  


Gln Asp Val Gly Glu Thr Glu Asp Asp Glu Ser Pro Glu Gln Arg Ala 
65                  70                  75                  80  


Arg Arg Pro Met Asn Ala Phe Leu Leu Phe Cys Lys Arg His Arg Ser 
                85                  90                  95      


Leu Val Arg Gln Glu His Pro Arg Leu Asp Asn Arg Gly Ala Thr Lys 
            100                 105                 110         


Ile Leu Ala Asp Trp Trp Ala Val Leu Asp Pro Lys Glu Lys Gln Lys 
        115                 120                 125             


Tyr Thr Asp Met Ala Lys Glu Tyr Lys Asp Ala Phe Met Lys Ala Asn 
    130                 135                 140                 


Pro Gly Tyr Lys Trp Cys Pro Thr Thr Asn Lys Pro Val Lys Ser Pro 
145                 150                 155                 160 


Thr Pro Thr Val Asn Pro Arg Lys Lys Leu Trp Ala Phe Pro Ser Asp 
                165                 170                 175     


Ser Ser Arg Asp Leu Pro Ser Pro Lys Lys Ala Lys Thr Glu Glu Met 
            180                 185                 190         


Pro Gln Leu Asn Phe Gly Met Ala Asp Pro Thr Gln Met Gly Gly Leu 
        195                 200                 205             


Ser Met Leu Leu Leu Ala Gly Glu His Ala Leu Gly Thr Pro Glu Val 
    210                 215                 220                 


Ser Ser Gly Thr Cys Arg Pro Asp Val Ser Glu Ser Pro Glu Leu Arg 
225                 230                 235                 240 


Gln Lys Ser Pro Leu Phe Gln Phe Ala Glu Ile Ser Ser Ser Thr Ser 
                245                 250                 255     


His Ser Asp Ala Ser Thr Lys Gln Cys Gln Thr Ser Ala Leu Phe Gln 
            260                 265                 270         


Phe Ala Glu Ile Ser Ser Asn Thr Ser Gln Leu Gly Gly Ala Glu Pro 
        275                 280                 285             


Val Lys Arg Cys Gly Lys Ser Ala Leu Phe Gln Leu Ala Glu Met Cys 
    290                 295                 300                 


Leu Ala Ser Glu Gly Met Lys Met Glu Glu Ser Lys Leu Ile Lys Ala 
305                 310                 315                 320 


Lys Glu Ser Asp Gly Gly Arg Ile Lys Glu Leu Glu Lys Gly Lys Glu 
                325                 330                 335     


Glu Lys Glu Ile Lys Met Glu Lys Thr Asp Glu Thr Arg Leu Gln Lys 
            340                 345                 350         


Glu Ala Glu Phe Glu Lys Ser Ala Lys Glu Asn Leu Arg Asp Ser Lys 
        355                 360                 365             


Glu Leu Arg Asn Phe Glu Ala Leu Gln Ile Asp Asp Ile Met Ala Ile 
    370                 375                 380                 


Lys Met Glu Asp Pro Lys Glu Ile Arg Lys Glu Glu Leu Glu Glu Asp 
385                 390                 395                 400 


His Lys Cys Ser His Phe Pro Asp Phe Ser Tyr Ser Ala Ser Ser Lys 
                405                 410                 415     


Ile Ile Ile Ser Asp Val Pro Ser Arg Lys Asp His Met Cys His Pro 
            420                 425                 430         


His Gly Ile Met Ile Ile Glu Asp Pro Ala Ala Leu Asn Lys Pro Glu 
        435                 440                 445             


Lys Leu Lys Lys Lys Lys Lys Lys Ser Lys Met Asp Arg His Gly Asn 
    450                 455                 460                 


Asp Lys Ser Thr Pro Lys Lys Thr Cys Lys Lys Arg Gln Ser Ser Glu 
465                 470                 475                 480 


Ser Asp Ile Glu Ser Val Ile Tyr Thr Ile Glu Ala Val Ala Lys Gly 
                485                 490                 495     


Asp Trp Gly Ile Glu Lys Leu Gly Asp Thr Pro Arg Lys Lys Val Arg 
            500                 505                 510         


Thr Ser Ser Ser Gly Lys Gly Ser Ile Leu Asp Ala Lys Pro Pro Lys 
        515                 520                 525             


Lys Lys Val Lys Ser Arg Glu Lys Lys Met Ser Lys Glu Lys Ser Ser 
    530                 535                 540                 


Asp Thr Thr Lys Glu Ser Arg Pro Pro Asp Phe Ile Ser Ile Ser Ala 
545                 550                 555                 560 


Ser Lys Asn Ile Ser Gly Glu Thr Pro Glu Gly Ile Lys Ala Glu Pro 
                565                 570                 575     


Leu Thr Pro Met Glu Asp Ala Leu Pro Pro Ser Leu Ser Gly Gln Ala 
            580                 585                 590         


Lys Pro Glu Asp Ser Asp Cys His Arg Lys Ile Glu Thr Cys Gly Ser 
        595                 600                 605             


Arg Lys Ser Glu Arg Ser Cys Lys Gly Ala Leu Tyr Lys Thr Leu Val 
    610                 615                 620                 


Ser Glu Gly Met Leu Thr Ser Leu Arg Ala Asn Val Asp Arg Gly Lys 
625                 630                 635                 640 


Arg Ser Ser Gly Lys Gly Asn Ser Ser Asp His Glu Gly Cys Trp Asn 
                645                 650                 655     


Glu Glu Ser Trp Thr Phe Ser Gln Ser Gly Thr Ser Gly Ser Lys Lys 
            660                 665                 670         


Phe Lys Lys Thr Lys Pro Lys Glu Asp Cys Leu Leu Gly Ser Ala Lys 
        675                 680                 685             


Leu Asp Glu Glu Phe Glu Lys Lys Phe Asn Ser Leu Pro Gln Tyr Ser 
    690                 695                 700                 


Pro Val Thr Phe Asp Arg Lys Cys Val Pro Val Pro Arg Lys Lys Lys 
705                 710                 715                 720 


Lys Thr Gly Asn Val Ser Ser Glu Pro Thr Lys Thr Ser Lys Gly Pro 
                725                 730                 735     


Phe Gln Ser Gln Lys Lys Asn Leu Phe His Lys Ile Val Ser Lys Tyr 
            740                 745                 750         


Lys His Lys Lys Glu Lys Pro Asn Val Pro Glu Lys Gly Ser Gly Asp 
        755                 760                 765             


Lys Trp Ser Asn Lys Gln Leu Phe Leu Asp Ala Ile His Pro Thr Glu 
    770                 775                 780                 


Ala Ile Phe Ser Glu Asp Arg Asn Thr Met Glu Pro Val His Lys Val 
785                 790                 795                 800 


Lys Asn Ile Pro Ser Ile Phe Asn Thr Pro Glu Pro Thr Thr Thr Gln 
                805                 810                 815     


Glu Pro Leu Val Gly Ser Gln Lys Arg Lys Ala Arg Lys Thr Lys Ile 
            820                 825                 830         


Thr His Leu Val Arg Thr Ala Asp Gly Arg Val Ser Pro Ala Gly Gly 
        835                 840                 845             


Thr Leu Asp Asp Lys Pro Lys Glu Gln Leu Gln Arg Ser Leu Pro Lys 
    850                 855                 860                 


Ala Thr Glu Thr Asp Cys Asn Asp Lys Cys Ser His Asn Thr Glu Val 
865                 870                 875                 880 


Gly Glu Thr Arg Ser Ser Thr Pro Glu Met Pro Ala Val Ser Ala Phe 
                885                 890                 895     


Phe Ser Leu Ala Ala Leu Ala Glu Val Ala Ala Met Glu Asn Val His 
            900                 905                 910         


Arg Gly Gln Arg Ser Thr Pro Leu Thr His Asp Gly Gln Pro Lys Glu 
        915                 920                 925             


Met Pro Gln Ala Pro Val Leu Ile Ser Cys Ala Asp Gln 
    930                 935                 940     


<210>  1079
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAM__Homo_sapiens__NP_001013275

<400>  1079

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro 
            580                 585             


<210>  1080
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAN__Homo_sapiens__NP_940819

<400>  1080

Met Ala Gln Leu Phe Leu Pro Leu Leu Ala Ala Leu Val Leu Ala Gln 
1               5                   10                  15      


Ala Pro Ala Ala Leu Ala Asp Val Leu Glu Gly Asp Ser Ser Glu Asp 
            20                  25                  30          


Arg Ala Phe Arg Val Arg Ile Ala Gly Asp Ala Pro Leu Gln Gly Val 
        35                  40                  45              


Leu Gly Gly Ala Leu Thr Ile Pro Cys His Val His Tyr Leu Arg Pro 
    50                  55                  60                  


Pro Pro Ser Arg Arg Ala Val Leu Gly Ser Pro Arg Val Lys Trp Thr 
65                  70                  75                  80  


Phe Leu Ser Arg Gly Arg Glu Ala Glu Val Leu Val Ala Arg Gly Val 
                85                  90                  95      


Arg Val Lys Val Asn Glu Ala Tyr Arg Phe Arg Val Ala Leu Pro Ala 
            100                 105                 110         


Tyr Pro Ala Ser Leu Thr Asp Val Ser Leu Ala Leu Ser Glu Leu Arg 
        115                 120                 125             


Pro Asn Asp Ser Gly Ile Tyr Arg Cys Glu Val Gln His Gly Ile Asp 
    130                 135                 140                 


Asp Ser Ser Asp Ala Val Glu Val Lys Val Lys Gly Val Val Phe Leu 
145                 150                 155                 160 


Tyr Arg Glu Gly Ser Ala Arg Tyr Ala Phe Ser Phe Ser Gly Ala Gln 
                165                 170                 175     


Glu Ala Cys Ala Arg Ile Gly Ala His Ile Ala Thr Pro Glu Gln Leu 
            180                 185                 190         


Tyr Ala Ala Tyr Leu Gly Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu 
        195                 200                 205             


Ser Asp Gln Thr Val Arg Tyr Pro Ile Gln Thr Pro Arg Glu Ala Cys 
    210                 215                 220                 


Tyr Gly Asp Met Asp Gly Phe Pro Gly Val Arg Asn Tyr Gly Val Val 
225                 230                 235                 240 


Asp Pro Asp Asp Leu Tyr Asp Val Tyr Cys Tyr Ala Glu Asp Leu Asn 
                245                 250                 255     


Gly Glu Leu Phe Leu Gly Asp Pro Pro Glu Lys Leu Thr Leu Glu Glu 
            260                 265                 270         


Ala Arg Ala Tyr Cys Gln Glu Arg Gly Ala Glu Ile Ala Thr Thr Gly 
        275                 280                 285             


Gln Leu Tyr Ala Ala Trp Asp Gly Gly Leu Asp His Cys Ser Pro Gly 
    290                 295                 300                 


Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Val Thr Pro Ser Gln 
305                 310                 315                 320 


Arg Cys Gly Gly Gly Leu Pro Gly Val Lys Thr Leu Phe Leu Phe Pro 
                325                 330                 335     


Asn Gln Thr Gly Phe Pro Asn Lys His Ser Arg Phe Asn Val Tyr Cys 
            340                 345                 350         


Phe Arg Asp Ser Ala Gln Pro Ser Ala Ile Pro Glu Ala Ser Asn Pro 
        355                 360                 365             


Ala Ser Asn Pro Ala Ser Asp Gly Leu Glu Ala Ile Val Thr Val Thr 
    370                 375                 380                 


Glu Thr Leu Glu Glu Leu Gln Leu Pro Gln Glu Ala Thr Glu Ser Glu 
385                 390                 395                 400 


Ser Arg Gly Ala Ile Tyr Ser Ile Pro Ile Met Glu Asp Gly Gly Gly 
                405                 410                 415     


Gly Ser Ser Thr Pro Glu Asp Pro Ala Glu Ala Pro Arg Thr Leu Leu 
            420                 425                 430         


Glu Phe Glu Thr Gln Ser Met Val Pro Pro Thr Gly Phe Ser Glu Glu 
        435                 440                 445             


Glu Gly Lys Ala Leu Glu Glu Glu Glu Lys Tyr Glu Asp Glu Glu Glu 
    450                 455                 460                 


Lys Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asp Glu Ala Leu Trp 
465                 470                 475                 480 


Ala Trp Pro Ser Glu Leu Ser Ser Pro Gly Pro Glu Ala Ser Leu Pro 
                485                 490                 495     


Thr Glu Pro Ala Ala Gln Glu Glu Ser Leu Ser Gln Ala Pro Ala Arg 
            500                 505                 510         


Ala Val Leu Gln Pro Gly Ala Ser Pro Leu Pro Asp Gly Glu Ser Glu 
        515                 520                 525             


Ala Ser Arg Pro Pro Arg Val His Gly Pro Pro Thr Glu Thr Leu Pro 
    530                 535                 540                 


Thr Pro Arg Glu Arg Asn Leu Ala Ser Pro Ser Pro Ser Thr Leu Val 
545                 550                 555                 560 


Glu Ala Arg Glu Val Gly Glu Ala Thr Gly Gly Pro Glu Leu Ser Gly 
                565                 570                 575     


Val Pro Arg Gly Glu Ser Glu Glu Thr Gly Ser Ser Glu Gly Ala Pro 
            580                 585                 590         


Ser Leu Leu Pro Ala Thr Arg Ala Pro Glu Gly Thr Arg Glu Leu Glu 
        595                 600                 605             


Ala Pro Ser Glu Asp Asn Ser Gly Arg Thr Ala Pro Ala Gly Thr Ser 
    610                 615                 620                 


Val Gln Ala Gln Pro Val Leu Pro Thr Asp Ser Ala Ser Arg Gly Gly 
625                 630                 635                 640 


Val Ala Val Val Pro Ala Ser Gly Asn Ser Ala Gln Gly Ser Thr Ala 
                645                 650                 655     


Leu Ser Ile Leu Leu Leu Phe Phe Pro Leu Gln Leu Trp Val Thr 
            660                 665                 670     


<210>  1081
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAP29__Homo_sapiens__NP_001008405

<400>  1081

Met Thr Leu Gln Trp Ala Ala Val Ala Thr Phe Leu Tyr Ala Glu Ile 
1               5                   10                  15      


Gly Leu Ile Leu Ile Phe Cys Leu Pro Phe Ile Pro Pro Gln Arg Trp 
            20                  25                  30          


Gln Lys Ile Phe Ser Phe Asn Val Trp Gly Lys Ile Ala Thr Phe Trp 
        35                  40                  45              


Asn Lys Ala Phe Leu Thr Ile Ile Ile Leu Leu Ile Val Leu Phe Leu 
    50                  55                  60                  


Asp Ala Val Arg Glu Val Arg Lys Tyr Ser Ser Val His Thr Ile Glu 
65                  70                  75                  80  


Lys Ser Ser Thr Ser Arg Pro Asp Ala Tyr Glu His Thr Gln Met Lys 
                85                  90                  95      


Leu Phe Arg Ser Gln Arg Asn Leu Tyr Ile Ser Gly Phe Ser Leu Phe 
            100                 105                 110         


Phe Trp Leu Val Leu Arg Arg Leu Val Thr Leu Ile Thr Gln Leu Ala 
        115                 120                 125             


Lys Glu Leu Ser Asn Lys Gly Val Leu Lys Thr Gln Ala Glu Asn Thr 
    130                 135                 140                 


Asn Lys Ala Ala Lys Lys Phe Met Glu Glu Asn Glu Lys Leu Lys Arg 
145                 150                 155                 160 


Ile Leu Lys Ser His Gly Lys Asp Glu Glu Cys Val Leu Glu Ala Glu 
                165                 170                 175     


Asn Lys Lys Leu Val Glu Asp Gln Glu Lys Leu Lys Thr Glu Leu Arg 
            180                 185                 190         


Lys Thr Ser Asp Ala Leu Ser Lys Ala Gln Asn Asp Val Met Glu Met 
        195                 200                 205             


Lys Met Gln Ser Glu Arg Leu Ser Lys Glu Tyr Asp Gln Leu Leu Lys 
    210                 215                 220                 


Glu His Ser Glu Leu Gln His Ser Ser Phe Gly Glu Phe Leu Ser Lys 
225                 230                 235                 240 


Arg Ser His Lys Asn Gly Ser Ile Gly Lys Gln Thr Gly Ser Arg Lys 
                245                 250                 255     


Gly Ser Phe Arg Lys Arg Gln Gln Glu Lys Thr Val Asn Phe Ile Lys 
            260                 265                 270         


Asp Thr Cys Asn Ile Leu Cys Gln Asn Asp Asn Phe Val Met Leu Ala 
        275                 280                 285             


Ser Arg Lys Phe Lys Phe Arg Lys Met His Tyr Asp Arg Phe Val Ile 
    290                 295                 300                 


Phe Leu Met Pro His Ile Gly Cys Ile Val Met Ala Leu Ser Lys Tyr 
305                 310                 315                 320 


Leu Met Met Phe Gln Ile Tyr Cys Lys Val Cys Ile Pro Ala Leu Lys 
                325                 330                 335     


Lys Asn Ile Ser Met Leu Asn Thr Ile Phe Thr Tyr 
            340                 345             


<210>  1082
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAP31__Homo_sapiens__NP_001132929

<400>  1082

Met Gly Ala Glu Ala Ser Ser Ser Trp Cys Pro Gly Thr Ala Leu Pro 
1               5                   10                  15      


Glu Glu Arg Leu Ser Val Lys Arg Ala Ser Glu Ile Ser Gly Phe Leu 
            20                  25                  30          


Gly Gln Gly Ser Ser Gly Glu Ala Ala Leu Asp Val Leu Thr His Val 
        35                  40                  45              


Leu Glu Gly Ala Gly Asn Lys Leu Thr Ser Ser Cys Gly Lys Pro Ser 
    50                  55                  60                  


Ser Asn Arg Met Ser Leu Gln Trp Thr Ala Val Ala Thr Phe Leu Tyr 
65                  70                  75                  80  


Ala Glu Val Phe Val Val Leu Leu Leu Cys Ile Pro Phe Ile Ser Pro 
                85                  90                  95      


Lys Arg Trp Gln Lys Ile Phe Lys Ser Arg Leu Val Glu Leu Leu Val 
            100                 105                 110         


Ser Tyr Gly Asn Thr Phe Phe Val Val Leu Ile Val Ile Leu Val Leu 
        115                 120                 125             


Leu Val Ile Asp Ala Val Arg Glu Ile Arg Lys Tyr Asp Asp Val Thr 
    130                 135                 140                 


Glu Lys Val Asn Leu Gln Asn Asn Pro Gly Ala Met Glu His Phe His 
145                 150                 155                 160 


Met Lys Leu Phe Arg Ala Gln Arg Asn Leu Tyr Ile Ala Gly Phe Ser 
                165                 170                 175     


Leu Leu Leu Ser Phe Leu Leu Arg Arg Leu Val Thr Leu Ile Ser Gln 
            180                 185                 190         


Gln Ala Thr Leu Leu Ala Ser Asn Glu Ala Phe Lys Lys Gln Ala Glu 
        195                 200                 205             


Ser Ala Ser Glu Ala Ala Lys Lys Tyr Met Glu Glu Asn Asp Gln Leu 
    210                 215                 220                 


Lys Lys Gly Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn Ala 
225                 230                 235                 240 


Glu Val Lys Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Asp Leu Gln 
                245                 250                 255     


Lys Leu Lys Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys Ala 
            260                 265                 270         


Glu Asn Gln Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr Lys 
        275                 280                 285             


Glu Tyr Asp Arg Leu Leu Glu Glu His Ala Lys Leu Gln Ala Ala Val 
    290                 295                 300                 


Asp Gly Pro Met Asp Lys Lys Glu Glu 
305                 310             


<210>  1083
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAR1__Homo_sapiens__NP_001164185

<400>  1083

Met Pro Ala Lys Pro Phe Leu Ser Ser Val Leu Leu Ser Trp Lys Val 
1               5                   10                  15      


Leu Asp Phe Ser Gly Pro Gly Pro Gln Gly Thr Gly Gln Pro Cys Ser 
            20                  25                  30          


Cys Gly His Trp Ala Glu Gly Gln Gly Gly Pro Pro Glu Pro Ala Gly 
        35                  40                  45              


Gly Pro Asn Val Leu Ala Lys Ala Leu Tyr Asp Asn Val Ala Glu Ser 
    50                  55                  60                  


Pro Asp Glu Leu Ser Phe Arg Lys Gly Asp Ile Met Thr Val Leu Glu 
65                  70                  75                  80  


Gln Asp Thr Gln Gly Leu Asp Gly Trp Trp Leu Cys Ser Leu His Gly 
                85                  90                  95      


Arg Gln Gly Ile Val Pro Gly Asn Arg Leu Lys Ile Leu Val Gly Met 
            100                 105                 110         


Tyr Asp Lys Lys Pro Ala Gly Pro Gly Pro Gly Pro Pro Ala Thr Pro 
        115                 120                 125             


Ala Gln Pro Gln Pro Gly Leu His Ala Pro Ala Pro Pro Ala Ser Gln 
    130                 135                 140                 


Tyr Thr Pro Met Leu Pro Asn Thr Tyr Gln Pro Gln Pro Asp Ser Val 
145                 150                 155                 160 


Tyr Leu Val Pro Thr Pro Ser Lys Ala Gln Gln Gly Leu Tyr Gln Val 
                165                 170                 175     


Pro Gly Pro Ser Pro Gln Phe Gln Ser Pro Pro Ala Lys Gln Thr Ser 
            180                 185                 190         


Thr Phe Ser Lys Gln Thr Pro His His Pro Phe Pro Ser Pro Ala Thr 
        195                 200                 205             


Asp Leu Tyr Gln Val Pro Pro Gly Pro Gly Gly Pro Ala Gln Asp Ile 
    210                 215                 220                 


Tyr Gln Val Pro Pro Ser Ala Gly Met Gly His Asp Ile Tyr Gln Val 
225                 230                 235                 240 


Pro Pro Ser Met Asp Thr Arg Ser Trp Glu Gly Thr Lys Pro Pro Ala 
                245                 250                 255     


Lys Val Val Val Pro Thr Arg Val Gly Gln Gly Tyr Val Tyr Glu Ala 
            260                 265                 270         


Ala Gln Pro Glu Gln Asp Glu Tyr Asp Ile Pro Arg His Leu Leu Ala 
        275                 280                 285             


Pro Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg Gly Leu Leu 
    290                 295                 300                 


Pro Ser Gln Tyr Gly Gln Glu Val Tyr Asp Thr Pro Pro Met Ala Val 
305                 310                 315                 320 


Lys Gly Pro Asn Gly Arg Asp Pro Leu Leu Glu Val Tyr Asp Val Pro 
                325                 330                 335     


Pro Ser Val Glu Lys Gly Leu Pro Pro Ser Asn His His Ala Val Tyr 
            340                 345                 350         


Asp Val Pro Pro Ser Val Ser Lys Asp Val Pro Asp Gly Pro Leu Leu 
        355                 360                 365             


Arg Glu Glu Thr Tyr Asp Val Pro Pro Ala Phe Ala Lys Ala Lys Pro 
    370                 375                 380                 


Phe Asp Pro Ala Arg Thr Pro Leu Val Leu Ala Ala Pro Pro Pro Asp 
385                 390                 395                 400 


Ser Pro Pro Ala Glu Asp Val Tyr Asp Val Pro Pro Pro Ala Pro Asp 
                405                 410                 415     


Leu Tyr Asp Val Pro Pro Gly Leu Arg Arg Pro Gly Pro Gly Thr Leu 
            420                 425                 430         


Tyr Asp Val Pro Arg Glu Arg Val Leu Pro Pro Glu Val Ala Asp Gly 
        435                 440                 445             


Gly Val Val Asp Ser Gly Val Tyr Ala Val Pro Pro Pro Ala Glu Arg 
    450                 455                 460                 


Glu Ala Pro Ala Glu Gly Lys Arg Leu Ser Ala Ser Ser Thr Gly Ser 
465                 470                 475                 480 


Thr Arg Ser Ser Gln Ser Ala Ser Ser Leu Glu Val Ala Gly Pro Gly 
                485                 490                 495     


Arg Glu Pro Leu Glu Leu Glu Val Ala Val Glu Ala Leu Ala Arg Leu 
            500                 505                 510         


Gln Gln Gly Val Ser Ala Thr Val Ala His Leu Leu Asp Leu Ala Gly 
        515                 520                 525             


Ser Ala Gly Ala Thr Gly Ser Trp Arg Ser Pro Ser Glu Pro Gln Glu 
    530                 535                 540                 


Pro Leu Val Gln Asp Leu Gln Ala Ala Val Ala Ala Val Gln Ser Ala 
545                 550                 555                 560 


Val His Glu Leu Leu Glu Phe Ala Arg Ser Ala Val Gly Asn Ala Ala 
                565                 570                 575     


His Thr Ser Asp Arg Ala Leu His Ala Lys Leu Ser Arg Gln Leu Gln 
            580                 585                 590         


Lys Met Glu Asp Val His Gln Thr Leu Val Ala His Gly Gln Ala Leu 
        595                 600                 605             


Asp Ala Gly Arg Gly Gly Ser Gly Ala Thr Leu Glu Asp Leu Asp Arg 
    610                 615                 620                 


Leu Val Ala Cys Ser Arg Ala Val Pro Glu Asp Ala Lys Gln Leu Ala 
625                 630                 635                 640 


Ser Phe Leu His Gly Asn Ala Ser Leu Leu Phe Arg Arg Thr Lys Ala 
                645                 650                 655     


Thr Ala Pro Gly Pro Glu Gly Gly Gly Thr Leu His Pro Asn Pro Thr 
            660                 665                 670         


Asp Lys Thr Ser Ser Ile Gln Ser Arg Pro Leu Pro Ser Pro Pro Lys 
        675                 680                 685             


Phe Thr Ser Gln Asp Ser Pro Asp Gly Gln Tyr Glu Asn Ser Glu Gly 
    690                 695                 700                 


Gly Trp Met Glu Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu 
705                 710                 715                 720 


Phe Glu Lys Thr Gln Lys Glu Leu Leu Glu Lys Gly Ser Ile Thr Arg 
                725                 730                 735     


Gln Gly Lys Ser Gln Leu Glu Leu Gln Gln Leu Lys Gln Phe Glu Arg 
            740                 745                 750         


Leu Glu Gln Glu Val Ser Arg Pro Ile Asp His Asp Leu Ala Asn Trp 
        755                 760                 765             


Thr Pro Ala Gln Pro Leu Ala Pro Gly Arg Thr Gly Gly Leu Gly Pro 
    770                 775                 780                 


Ser Asp Arg Gln Leu Leu Leu Phe Tyr Leu Glu Gln Cys Glu Ala Asn 
785                 790                 795                 800 


Leu Thr Thr Leu Thr Asn Ala Val Asp Ala Phe Phe Thr Ala Val Ala 
                805                 810                 815     


Thr Asn Gln Pro Pro Lys Ile Phe Val Ala His Ser Lys Phe Val Ile 
            820                 825                 830         


Leu Ser Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Ser Arg Gln 
        835                 840                 845             


Ala Lys Ala Ala Asp Val Arg Ser Gln Val Thr His Tyr Ser Asn Leu 
    850                 855                 860                 


Leu Cys Asp Leu Leu Arg Gly Ile Val Ala Thr Thr Lys Ala Ala Ala 
865                 870                 875                 880 


Leu Gln Tyr Pro Ser Pro Ser Ala Ala Gln Asp Met Val Glu Arg Val 
                885                 890                 895     


Lys Glu Leu Gly His Ser Thr Gln Gln Phe Arg Arg Val Leu Gly Gln 
            900                 905                 910         


Leu Ala Ala Ala 
        915     


<210>  1084
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAS1__Homo_sapiens__NP_003648

<400>  1084

Met Gly Asn Gln Met Ser Val Pro Gln Arg Val Glu Asp Gln Glu Asn 
1               5                   10                  15      


Glu Pro Glu Ala Glu Thr Tyr Gln Asp Asn Ala Ser Ala Leu Asn Gly 
            20                  25                  30          


Val Pro Val Val Val Ser Thr His Thr Val Gln His Leu Glu Glu Val 
        35                  40                  45              


Asp Leu Gly Ile Ser Val Lys Thr Asp Asn Val Ala Thr Ser Ser Pro 
    50                  55                  60                  


Glu Thr Thr Glu Ile Ser Ala Val Ala Asp Ala Asn Gly Lys Asn Leu 
65                  70                  75                  80  


Gly Lys Glu Ala Lys Pro Glu Ala Pro Ala Ala Lys Ser Arg Phe Phe 
                85                  90                  95      


Leu Met Leu Ser Arg Pro Val Pro Gly Arg Thr Gly Asp Gln Ala Ala 
            100                 105                 110         


Asp Ser Ser Leu Gly Ser Val Lys Leu Asp Val Ser Ser Asn Lys Ala 
        115                 120                 125             


Pro Ala Asn Lys Asp Pro Ser Glu Ser Trp Thr Leu Pro Val Ala Ala 
    130                 135                 140                 


Gly Pro Gly Gln Asp Thr Asp Lys Thr Pro Gly His Ala Pro Ala Gln 
145                 150                 155                 160 


Asp Lys Val Leu Ser Ala Ala Arg Asp Pro Thr Leu Leu Pro Pro Glu 
                165                 170                 175     


Thr Gly Gly Ala Gly Gly Glu Ala Pro Ser Lys Pro Lys Asp Ser Ser 
            180                 185                 190         


Phe Phe Asp Lys Phe Phe Lys Leu Asp Lys Gly Gln Glu Lys Val Pro 
        195                 200                 205             


Gly Asp Ser Gln Gln Glu Ala Lys Arg Ala Glu His Gln Asp Lys Val 
    210                 215                 220                 


Asp Glu Val Pro Gly Leu Ser Gly Gln Ser Asp Asp Val Pro Ala Gly 
225                 230                 235                 240 


Lys Asp Ile Val Asp Gly Lys Glu Lys Glu Gly Gln Glu Leu Gly Thr 
                245                 250                 255     


Ala Asp Cys Ser Val Pro Gly Asp Pro Glu Gly Leu Glu Thr Ala Lys 
            260                 265                 270         


Asp Asp Ser Gln Ala Ala Ala Ile Ala Glu Asn Asn Asn Ser Ile Met 
        275                 280                 285             


Ser Phe Phe Lys Thr Leu Val Ser Pro Asn Lys Ala Glu Thr Lys Lys 
    290                 295                 300                 


Asp Pro Glu Asp Thr Gly Ala Glu Lys Ser Pro Thr Thr Ser Ala Asp 
305                 310                 315                 320 


Leu Lys Ser Asp Lys Ala Asn Phe Thr Ser Gln Glu Thr Gln Gly Ala 
                325                 330                 335     


Gly Lys Asn Ser Lys Gly Cys Asn Pro Ser Gly His Thr Gln Ser Val 
            340                 345                 350         


Thr Thr Pro Glu Pro Ala Lys Glu Gly Thr Lys Glu Lys Ser Gly Pro 
        355                 360                 365             


Thr Ser Leu Pro Leu Gly Lys Leu Phe Trp Lys Lys Ser Val Lys Glu 
    370                 375                 380                 


Asp Ser Val Pro Thr Gly Ala Glu Glu Asn Val Val Cys Glu Ser Pro 
385                 390                 395                 400 


Val Glu Ile Ile Lys Ser Lys Glu Val Glu Ser Ala Leu Gln Thr Val 
                405                 410                 415     


Asp Leu Asn Glu Gly Asp Ala Ala Pro Glu Pro Thr Glu Ala Lys Leu 
            420                 425                 430         


Lys Arg Glu Glu Ser Lys Pro Arg Thr Ser Leu Met Ala Phe Leu Arg 
        435                 440                 445             


Gln Met Ser Val Lys Gly Asp Gly Gly Ile Thr His Ser Glu Glu Ile 
    450                 455                 460                 


Asn Gly Lys Asp Ser Ser Cys Gln Thr Ser Asp Ser Thr Glu Lys Thr 
465                 470                 475                 480 


Ile Thr Pro Pro Glu Pro Glu Pro Thr Gly Ala Pro Gln Lys Gly Lys 
                485                 490                 495     


Glu Gly Ser Ser Lys Asp Lys Lys Ser Ala Ala Glu Met Asn Lys Gln 
            500                 505                 510         


Lys Ser Asn Lys Gln Glu Ala Lys Glu Pro Ala Gln Cys Thr Glu Gln 
        515                 520                 525             


Ala Thr Val Asp Thr Asn Ser Leu Gln Asn Gly Asp Lys Leu Gln Lys 
    530                 535                 540                 


Arg Pro Glu Lys Arg Gln Gln Ser Leu Gly Gly Phe Phe Lys Gly Leu 
545                 550                 555                 560 


Gly Pro Lys Arg Met Leu Asp Ala Gln Val Gln Thr Asp Pro Val Ser 
                565                 570                 575     


Ile Gly Pro Val Gly Lys Ser Lys 
            580                 


<210>  1085
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAS3__Homo_sapiens__NP_001092902

<400>  1085

Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys 
1               5                   10                  15      


Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Glu Gln Ser Tyr 
            20                  25                  30          


Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Ala Tyr 
        35                  40                  45              


Ser Gly Thr Pro Leu Thr Glu Glu Lys Glu Lys Ile Val Trp Val Arg 
    50                  55                  60                  


Phe Glu Asn Ala Asp Leu Asn Asp Thr Ser Arg Asn Leu Glu Phe His 
65                  70                  75                  80  


Glu Ile His Ser Thr Gly Asn Glu Pro Pro Leu Leu Ile Met Ile Gly 
                85                  90                  95      


Tyr Ser Asp Gly Met Gln Val Trp Ser Ile Pro Ile Ser Gly Glu Ala 
            100                 105                 110         


Gln Glu Leu Phe Ser Val Arg His Gly Pro Ile Arg Ala Ala Arg Ile 
        115                 120                 125             


Leu Pro Ala Pro Gln Phe Gly Ala Gln Lys Cys Asp Asn Phe Ala Glu 
    130                 135                 140                 


Lys Arg Pro Leu Leu Gly Val Cys Lys Ser Ile Gly Ser Ser Gly Thr 
145                 150                 155                 160 


Ser Pro Pro Tyr Cys Cys Val Asp Leu Tyr Ser Leu Arg Thr Gly Glu 
                165                 170                 175     


Met Val Lys Ser Ile Gln Phe Lys Thr Pro Ile Tyr Asp Leu His Cys 
            180                 185                 190         


Asn Lys Arg Ile Leu Val Val Val Leu Gln Glu Lys Ile Ala Ala Phe 
        195                 200                 205             


Asp Ser Cys Thr Phe Thr Lys Lys Phe Phe Val Thr Ser Cys Tyr Pro 
    210                 215                 220                 


Cys Pro Gly Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu 
225                 230                 235                 240 


Ala Tyr Ala Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly 
                245                 250                 255     


Ala Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala 
            260                 265                 270         


Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr 
        275                 280                 285             


Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala 
    290                 295                 300                 


Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr 
305                 310                 315                 320 


Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu 
                325                 330                 335     


Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys 
            340                 345                 350         


Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr 
        355                 360                 365             


Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His 
    370                 375                 380                 


Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His 
385                 390                 395                 400 


Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp 
                405                 410                 415     


Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe 
            420                 425                 430         


Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser 
        435                 440                 445             


Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu 
    450                 455                 460                 


Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser 
465                 470                 475                 480 


Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly 
                485                 490                 495     


Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro 
            500                 505                 510         


Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro 
        515                 520                 525             


Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg 
    530                 535                 540                 


Thr Gly Pro Tyr Leu Phe Gly Ala Gly Cys Phe Ser Ile Lys Ala Pro 
545                 550                 555                 560 


Cys Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met Gly 
                565                 570                 575     


Gly Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp Phe 
            580                 585                 590         


Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln Val 
        595                 600                 605             


Val Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val Glu 
    610                 615                 620                 


His Met Met Glu Pro Arg Pro Leu Ser Thr Ala Pro Lys Ile Ser Asp 
625                 630                 635                 640 


Asp Thr Pro Leu Glu Met Met Thr Ser Pro Arg Ala Ser Trp Thr Leu 
                645                 650                 655     


Val Arg Thr Pro Gln Trp Asn Glu Leu Gln Pro Pro Phe Asn Ala Asn 
            660                 665                 670         


His Pro Leu Leu Leu Ala Ala Asp Ala Val Gln Tyr Tyr Gln Phe Leu 
        675                 680                 685             


Leu Ala Gly Leu Val Pro Pro Gly Ser Pro Gly Pro Ile Thr Arg His 
    690                 695                 700                 


Gly Ser Tyr Asp Ser Leu Ala Ser Asp His Ser Gly Gln Glu Asp Glu 
705                 710                 715                 720 


Glu Trp Leu Ser Gln Val Glu Ile Val Thr His Thr Gly Pro His Arg 
                725                 730                 735     


Arg Leu Trp Met Gly Pro Gln Phe Gln Phe Lys Thr Ile His Pro Ser 
            740                 745                 750         


Gly Gln Thr Thr Val Ile Ser Ser Ser Ser Ser Val Leu Gln Ser His 
        755                 760                 765             


Gly Pro Ser Asp Thr Pro Gln Pro Leu Leu Asp Phe Asp Thr Asp Asp 
    770                 775                 780                 


Leu Asp Leu Asn Ser Leu Arg Ile Gln Pro Val Arg Ser Asp Pro Val 
785                 790                 795                 800 


Ser Met Pro Gly Ser Ser Arg Pro Val Ser Asp Arg Arg Gly Val Ser 
                805                 810                 815     


Thr Val Ile Asp Ala Ala Ser Gly Thr Phe Asp Arg Ser Val Thr Leu 
            820                 825                 830         


Leu Glu Val Cys Gly Ser Trp Pro Glu Gly Phe Gly Leu Arg His Met 
        835                 840                 845             


Ser Ser Met Glu His Thr Glu Glu Gly Leu Arg Glu Arg Leu Ala Asp 
    850                 855                 860                 


Ala Met Ala Glu Ser Pro Ser Arg Asp Val Val Gly Ser Gly Thr Glu 
865                 870                 875                 880 


Leu Gln Arg Glu Gly Ser Ile Glu Thr Leu Ser Asn Ser Ser Gly Ser 
                885                 890                 895     


Thr Ser Gly Ser Ile Pro Arg Asn Phe Asp Gly Tyr Arg Ser Pro Leu 
            900                 905                 910         


Pro Thr Asn Glu Ser Gln Pro Leu Ser Leu Phe Pro Thr Gly Phe Pro 
        915                 920                 925             


<210>  1086
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAS4__Homo_sapiens__NP_001010974

<400>  1086

Met Gln Arg Thr Gly Gly Gly Ala Pro Arg Pro Gly Arg Asn His Gly 
1               5                   10                  15      


Leu Pro Gly Ser Leu Arg Gln Pro Asp Pro Val Ala Leu Leu Met Leu 
            20                  25                  30          


Leu Val Asp Ala Asp Gln Pro Glu Pro Met Arg Ser Gly Ala Arg Glu 
        35                  40                  45              


Leu Ala Leu Phe Leu Thr Pro Glu Pro Gly Ala Glu Ala Lys Glu Val 
    50                  55                  60                  


Glu Glu Thr Ile Glu Gly Met Leu Leu Arg Leu Glu Glu Phe Cys Ser 
65                  70                  75                  80  


Leu Ala Asp Leu Ile Arg Ser Asp Thr Ser Gln Ile Leu Glu Glu Asn 
                85                  90                  95      


Ile Pro Val Leu Lys Ala Lys Leu Thr Glu Met Arg Gly Ile Tyr Ala 
            100                 105                 110         


Lys Val Asp Arg Leu Glu Lys Ser Pro Ala Pro Val Pro Val Thr Tyr 
        115                 120                 125             


Glu Leu Pro Thr Leu Tyr Arg Thr Glu Asp Tyr Phe Pro Val Asp Ala 
    130                 135                 140                 


Gly Glu Ala Gln His His Pro Arg Thr Cys Pro Arg Pro Leu 
145                 150                 155             


<210>  1087
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAT1__Homo_sapiens__NP_001171562

<400>  1087

Met Lys Asp Cys Ser Asn Gly Cys Ser Ala Glu Cys Thr Gly Glu Gly 
1               5                   10                  15      


Gly Ser Lys Glu Val Val Gly Thr Phe Lys Ala Lys Asp Leu Ile Val 
            20                  25                  30          


Thr Pro Ala Thr Ile Leu Lys Glu Lys Pro Asp Pro Asn Asn Leu Val 
        35                  40                  45              


Phe Gly Thr Val Phe Thr Asp His Met Leu Thr Val Glu Trp Ser Ser 
    50                  55                  60                  


Glu Phe Gly Trp Glu Lys Pro His Ile Lys Pro Leu Gln Asn Leu Ser 
65                  70                  75                  80  


Leu His Pro Gly Ser Ser Ala Leu His Tyr Ala Val Glu Val Phe Asp 
                85                  90                  95      


Lys Glu Glu Leu Leu Glu Cys Ile Gln Gln Leu Val Lys Leu Asp Gln 
            100                 105                 110         


Glu Trp Val Pro Tyr Ser Thr Ser Ala Ser Leu Tyr Ile Arg Pro Thr 
        115                 120                 125             


Phe Ile Gly Thr Glu Pro Ser Leu Gly Val Lys Lys Pro Thr Lys Ala 
    130                 135                 140                 


Leu Leu Phe Val Leu Leu Ser Pro Val Gly Pro Tyr Phe Ser Ser Gly 
145                 150                 155                 160 


Thr Phe Asn Pro Val Ser Leu Trp Ala Asn Pro Lys Tyr Val Arg Ala 
                165                 170                 175     


Trp Lys Gly Gly Thr Gly Asp Cys Lys Met Gly Gly Asn Tyr Gly Ser 
            180                 185                 190         


Ser Leu Phe Ala Gln Cys Glu Ala Val Asp Asn Gly Cys Gln Gln Val 
        195                 200                 205             


Leu Trp Leu Tyr Gly Glu Asp His Gln Ile Thr Glu Val Gly Thr Met 
    210                 215                 220                 


Asn Leu Phe Leu Tyr Trp Ile Asn Glu Asp Gly Glu Glu Glu Leu Ala 
225                 230                 235                 240 


Thr Pro Pro Leu Asp Gly Ile Ile Leu Pro Gly Val Thr Arg Arg Cys 
                245                 250                 255     


Ile Leu Asp Leu Ala His Gln Trp Gly Glu Phe Lys Val Ser Glu Arg 
            260                 265                 270         


Tyr Leu Thr Met Asp Asp Leu Thr Thr Ala Leu Glu Gly Asn Arg Val 
        275                 280                 285             


Arg Glu Met Phe Gly Ser Gly Thr Ala Cys Val Val Cys Pro Val Ser 
    290                 295                 300                 


Asp Ile Leu Tyr Lys Gly Glu Thr Ile His Ile Pro Thr Met Glu Asn 
305                 310                 315                 320 


Gly Pro Lys Leu Ala Ser Arg Ile Leu Ser Lys Leu Thr Asp Ile Gln 
                325                 330                 335     


Tyr Gly Arg Glu Glu Ser Asp Trp Thr Ile Val Leu Ser 
            340                 345                 


<210>  1088
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCAT2__Homo_sapiens__NP_001158245

<400>  1088

Met Ala Ala Ala Ala Leu Gly Gln Leu Phe Glu Gly Met Lys Ala Phe 
1               5                   10                  15      


Lys Gly Lys Asp Gln Gln Val Arg Leu Phe Arg Pro Trp Leu Asn Met 
            20                  25                  30          


Asp Arg Met Leu Arg Ser Ala Met Arg Leu Cys Leu Pro Ser Phe Asp 
        35                  40                  45              


Lys Leu Glu Leu Leu Glu Cys Ile Arg Arg Leu Ile Glu Val Asp Lys 
    50                  55                  60                  


Asp Trp Val Pro Asp Ala Ala Gly Thr Ser Leu Tyr Val Arg Pro Val 
65                  70                  75                  80  


Leu Ile Gly Asn Glu Pro Ser Leu Gly Val Ser Gln Pro Thr Arg Ala 
                85                  90                  95      


Leu Leu Phe Val Ile Leu Cys Pro Val Gly Ala Tyr Phe Pro Gly Gly 
            100                 105                 110         


Ser Val Thr Pro Val Ser Leu Leu Ala Asp Pro Ala Phe Ile Arg Ala 
        115                 120                 125             


Trp Val Gly Gly Val Gly Asn Tyr Lys Leu Gly Gly Asn Tyr Gly Pro 
    130                 135                 140                 


Thr Val Leu Val Gln Gln Glu Ala Leu Lys Arg Gly Cys Glu Gln Val 
145                 150                 155                 160 


Leu Trp Leu Tyr Gly Pro Asp His Gln Leu Thr Glu Val Gly Thr Met 
                165                 170                 175     


Asn Ile Phe Val Tyr Trp Thr His Glu Asp Gly Val Leu Glu Leu Val 
            180                 185                 190         


Thr Pro Pro Leu Asn Gly Val Ile Leu Pro Gly Val Val Arg Gln Ser 
        195                 200                 205             


Leu Leu Asp Met Ala Gln Thr Trp Gly Glu Phe Arg Val Val Glu Arg 
    210                 215                 220                 


Thr Ile Thr Met Lys Gln Leu Leu Arg Ala Leu Glu Glu Gly Arg Val 
225                 230                 235                 240 


Arg Glu Val Phe Gly Ser Gly Thr Ala Cys Gln Val Cys Pro Val His 
                245                 250                 255     


Arg Ile Leu Tyr Lys Asp Arg Asn Leu His Ile Pro Thr Met Glu Asn 
            260                 265                 270         


Gly Pro Glu Leu Ile Leu Arg Phe Gln Lys Glu Leu Lys Glu Ile Gln 
        275                 280                 285             


Tyr Gly Ile Arg Ala His Glu Trp Met Phe Pro Val 
    290                 295                 300 


<210>  1089
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCCIP__Homo_sapiens__NP_057651

<400>  1089

Met Ala Ser Arg Ser Lys Arg Arg Ala Val Glu Ser Gly Val Pro Gln 
1               5                   10                  15      


Pro Pro Asp Pro Pro Val Gln Arg Asp Glu Glu Glu Glu Lys Glu Val 
            20                  25                  30          


Glu Asn Glu Asp Glu Asp Asp Asp Asp Ser Asp Lys Glu Lys Asp Glu 
        35                  40                  45              


Glu Asp Glu Val Ile Asp Glu Glu Val Asn Ile Glu Phe Glu Ala Tyr 
    50                  55                  60                  


Ser Leu Ser Asp Asn Asp Tyr Asp Gly Ile Lys Lys Leu Leu Gln Gln 
65                  70                  75                  80  


Leu Phe Leu Lys Ala Pro Val Asn Thr Ala Glu Leu Thr Asp Leu Leu 
                85                  90                  95      


Ile Gln Gln Asn His Ile Gly Ser Val Ile Lys Gln Thr Asp Val Ser 
            100                 105                 110         


Glu Asp Ser Asn Asp Asp Met Asp Glu Asp Glu Val Phe Gly Phe Ile 
        115                 120                 125             


Ser Leu Leu Asn Leu Thr Glu Arg Lys Gly Thr Gln Cys Val Glu Gln 
    130                 135                 140                 


Ile Gln Glu Leu Val Leu Arg Phe Cys Glu Lys Asn Cys Glu Lys Ser 
145                 150                 155                 160 


Met Val Glu Gln Leu Asp Lys Phe Leu Asn Asp Thr Thr Lys Pro Val 
                165                 170                 175     


Gly Leu Leu Leu Ser Glu Arg Phe Ile Asn Val Pro Pro Gln Ile Ala 
            180                 185                 190         


Leu Pro Met Tyr Gln Gln Leu Gln Lys Glu Leu Ala Gly Ala His Arg 
        195                 200                 205             


Thr Asn Lys Pro Cys Gly Lys Cys Tyr Phe Tyr Leu Leu Ile Ser Lys 
    210                 215                 220                 


Thr Phe Val Glu Ala Gly Lys Asn Asn Ser Lys Lys Lys Pro Ser Asn 
225                 230                 235                 240 


Lys Lys Lys Ala Ala Leu Met Phe Ala Asn Ala Glu Glu Glu Phe Phe 
                245                 250                 255     


Tyr Glu Glu Gln Gly Lys Pro Glu Val Leu Gly Gly Pro Asp Thr Arg 
            260                 265                 270         


Arg Gly Leu Glu Pro Val Pro Ile Gln His Asn Gly Gly Ser Arg Gly 
        275                 280                 285             


Gln Val Thr Ala Leu Val Ser Leu Lys Ala Gly Leu Ile Gln Ser Arg 
    290                 295                 300                 


Ser Thr Leu Ser Asp Phe Gln Gly Thr Phe Met Thr Val Gly Ile Ala 
305                 310                 315                 320 


Leu Ser 
        


<210>  1090
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCDIN3D__Homo_sapiens__NP_859059

<400>  1090

Met Ala Val Pro Thr Glu Leu Asp Gly Gly Ser Val Lys Glu Thr Ala 
1               5                   10                  15      


Ala Glu Glu Glu Ser Arg Val Leu Ala Pro Gly Ala Ala Pro Phe Gly 
            20                  25                  30          


Asn Phe Pro His Tyr Ser Arg Phe His Pro Pro Glu Gln Arg Leu Arg 
        35                  40                  45              


Leu Leu Pro Pro Glu Leu Leu Arg Gln Leu Phe Pro Glu Ser Pro Glu 
    50                  55                  60                  


Asn Gly Pro Ile Leu Gly Leu Asp Val Gly Cys Asn Ser Gly Asp Leu 
65                  70                  75                  80  


Ser Val Ala Leu Tyr Lys His Phe Leu Ser Leu Pro Asp Gly Glu Thr 
                85                  90                  95      


Cys Ser Asp Ala Ser Arg Glu Phe Arg Leu Leu Cys Cys Asp Ile Asp 
            100                 105                 110         


Pro Val Leu Val Lys Arg Ala Glu Lys Glu Cys Pro Phe Pro Asp Ala 
        115                 120                 125             


Leu Thr Phe Ile Thr Leu Asp Phe Met Asn Gln Arg Thr Arg Lys Val 
    130                 135                 140                 


Leu Leu Ser Ser Phe Leu Ser Gln Phe Gly Arg Ser Val Phe Asp Ile 
145                 150                 155                 160 


Gly Phe Cys Met Ser Ile Thr Met Trp Ile His Leu Asn His Gly Asp 
                165                 170                 175     


His Gly Leu Trp Glu Phe Leu Ala His Leu Ser Ser Leu Cys His Tyr 
            180                 185                 190         


Leu Leu Val Glu Pro Gln Pro Trp Lys Cys Tyr Arg Ala Ala Ala Arg 
        195                 200                 205             


Arg Leu Arg Lys Leu Gly Leu His Asp Phe Asp His Phe His Ser Leu 
    210                 215                 220                 


Ala Ile Arg Gly Asp Met Pro Asn Gln Ile Val Gln Ile Leu Thr Gln 
225                 230                 235                 240 


Asp His Gly Met Glu Leu Ile Cys Cys Phe Gly Asn Thr Ser Trp Asp 
                245                 250                 255     


Arg Ser Leu Leu Leu Phe Arg Ala Lys Gln Thr Ile Glu Thr His Pro 
            260                 265                 270         


Ile Pro Glu Ser Leu Ile Glu Lys Gly Lys Glu Lys Asn Arg Leu Ser 
        275                 280                 285             


Phe Gln Lys Gln 
    290         


<210>  1091
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCHE__Homo_sapiens__NP_000046

<400>  1091

Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
1               5                   10                  15      


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
            20                  25                  30          


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
        35                  40                  45              


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
    50                  55                  60                  


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
65                  70                  75                  80  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
                85                  90                  95      


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
            100                 105                 110         


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
        115                 120                 125             


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
    130                 135                 140                 


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
145                 150                 155                 160 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
                165                 170                 175     


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
            180                 185                 190         


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
225                 230                 235                 240 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
                245                 250                 255     


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
            260                 265                 270         


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
        275                 280                 285             


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
    290                 295                 300                 


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
305                 310                 315                 320 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
                325                 330                 335     


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
            340                 345                 350         


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
        355                 360                 365             


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
    370                 375                 380                 


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
385                 390                 395                 400 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
                405                 410                 415     


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
            420                 425                 430         


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
        435                 440                 445             


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
    450                 455                 460                 


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
465                 470                 475                 480 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
                485                 490                 495     


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln 
            500                 505                 510         


Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr 
        515                 520                 525             


Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala 
    530                 535                 540                 


Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met 
545                 550                 555                 560 


Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His 
                565                 570                 575     


Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr 
            580                 585                 590         


Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
        595                 600         


<210>  1092
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCKDHA__Homo_sapiens__NP_000700

<400>  1092

Met Ala Val Ala Ile Ala Ala Ala Arg Val Trp Arg Leu Asn Arg Gly 
1               5                   10                  15      


Leu Ser Gln Ala Ala Leu Leu Leu Leu Arg Gln Pro Gly Ala Arg Gly 
            20                  25                  30          


Leu Ala Arg Ser His Pro Pro Arg Gln Gln Gln Gln Phe Ser Ser Leu 
        35                  40                  45              


Asp Asp Lys Pro Gln Phe Pro Gly Ala Ser Ala Glu Phe Ile Asp Lys 
    50                  55                  60                  


Leu Glu Phe Ile Gln Pro Asn Val Ile Ser Gly Ile Pro Ile Tyr Arg 
65                  70                  75                  80  


Val Met Asp Arg Gln Gly Gln Ile Ile Asn Pro Ser Glu Asp Pro His 
                85                  90                  95      


Leu Pro Lys Glu Lys Val Leu Lys Leu Tyr Lys Ser Met Thr Leu Leu 
            100                 105                 110         


Asn Thr Met Asp Arg Ile Leu Tyr Glu Ser Gln Arg Gln Gly Arg Ile 
        115                 120                 125             


Ser Phe Tyr Met Thr Asn Tyr Gly Glu Glu Gly Thr His Val Gly Ser 
    130                 135                 140                 


Ala Ala Ala Leu Asp Asn Thr Asp Leu Val Phe Gly Gln Tyr Arg Glu 
145                 150                 155                 160 


Ala Gly Val Leu Met Tyr Arg Asp Tyr Pro Leu Glu Leu Phe Met Ala 
                165                 170                 175     


Gln Cys Tyr Gly Asn Ile Ser Asp Leu Gly Lys Gly Arg Gln Met Pro 
            180                 185                 190         


Val His Tyr Gly Cys Lys Glu Arg His Phe Val Thr Ile Ser Ser Pro 
        195                 200                 205             


Leu Ala Thr Gln Ile Pro Gln Ala Val Gly Ala Ala Tyr Ala Ala Lys 
    210                 215                 220                 


Arg Ala Asn Ala Asn Arg Val Val Ile Cys Tyr Phe Gly Glu Gly Ala 
225                 230                 235                 240 


Ala Ser Glu Gly Asp Ala His Ala Gly Phe Asn Phe Ala Ala Thr Leu 
                245                 250                 255     


Glu Cys Pro Ile Ile Phe Phe Cys Arg Asn Asn Gly Tyr Ala Ile Ser 
            260                 265                 270         


Thr Pro Thr Ser Glu Gln Tyr Arg Gly Asp Gly Ile Ala Ala Arg Gly 
        275                 280                 285             


Pro Gly Tyr Gly Ile Met Ser Ile Arg Val Asp Gly Asn Asp Val Phe 
    290                 295                 300                 


Ala Val Tyr Asn Ala Thr Lys Glu Ala Arg Arg Arg Ala Val Ala Glu 
305                 310                 315                 320 


Asn Gln Pro Phe Leu Ile Glu Ala Met Thr Tyr Arg Ile Gly His His 
                325                 330                 335     


Ser Thr Ser Asp Asp Ser Ser Ala Tyr Arg Ser Val Asp Glu Val Asn 
            340                 345                 350         


Tyr Trp Asp Lys Gln Asp His Pro Ile Ser Arg Leu Arg His Tyr Leu 
        355                 360                 365             


Leu Ser Gln Gly Trp Trp Asp Glu Glu Gln Glu Lys Ala Trp Arg Lys 
    370                 375                 380                 


Gln Ser Arg Arg Lys Val Met Glu Ala Phe Glu Gln Ala Glu Arg Lys 
385                 390                 395                 400 


Pro Lys Pro Asn Pro Asn Leu Leu Phe Ser Asp Val Tyr Gln Glu Met 
                405                 410                 415     


Pro Ala Gln Leu Arg Lys Gln Gln Glu Ser Leu Ala Arg His Leu Gln 
            420                 425                 430         


Thr Tyr Gly Glu His Tyr Pro Leu Asp His Phe Asp Lys 
        435                 440                 445 


<210>  1093
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCKDHB__Homo_sapiens__NP_000047

<400>  1093

Met Ala Val Val Ala Ala Ala Ala Gly Trp Leu Leu Arg Leu Arg Ala 
1               5                   10                  15      


Ala Gly Ala Glu Gly His Trp Arg Arg Leu Pro Gly Ala Gly Leu Ala 
            20                  25                  30          


Arg Gly Phe Leu His Pro Ala Ala Thr Val Glu Asp Ala Ala Gln Arg 
        35                  40                  45              


Arg Gln Val Ala His Phe Thr Phe Gln Pro Asp Pro Glu Pro Arg Glu 
    50                  55                  60                  


Tyr Gly Gln Thr Gln Lys Met Asn Leu Phe Gln Ser Val Thr Ser Ala 
65                  70                  75                  80  


Leu Asp Asn Ser Leu Ala Lys Asp Pro Thr Ala Val Ile Phe Gly Glu 
                85                  90                  95      


Asp Val Ala Phe Gly Gly Val Phe Arg Cys Thr Val Gly Leu Arg Asp 
            100                 105                 110         


Lys Tyr Gly Lys Asp Arg Val Phe Asn Thr Pro Leu Cys Glu Gln Gly 
        115                 120                 125             


Ile Val Gly Phe Gly Ile Gly Ile Ala Val Thr Gly Ala Thr Ala Ile 
    130                 135                 140                 


Ala Glu Ile Gln Phe Ala Asp Tyr Ile Phe Pro Ala Phe Asp Gln Ile 
145                 150                 155                 160 


Val Asn Glu Ala Ala Lys Tyr Arg Tyr Arg Ser Gly Asp Leu Phe Asn 
                165                 170                 175     


Cys Gly Ser Leu Thr Ile Arg Ser Pro Trp Gly Cys Val Gly His Gly 
            180                 185                 190         


Ala Leu Tyr His Ser Gln Ser Pro Glu Ala Phe Phe Ala His Cys Pro 
        195                 200                 205             


Gly Ile Lys Val Val Ile Pro Arg Ser Pro Phe Gln Ala Lys Gly Leu 
    210                 215                 220                 


Leu Leu Ser Cys Ile Glu Asp Lys Asn Pro Cys Ile Phe Phe Glu Pro 
225                 230                 235                 240 


Lys Ile Leu Tyr Arg Ala Ala Ala Glu Glu Val Pro Ile Glu Pro Tyr 
                245                 250                 255     


Asn Ile Pro Leu Ser Gln Ala Glu Val Ile Gln Glu Gly Ser Asp Val 
            260                 265                 270         


Thr Leu Val Ala Trp Gly Thr Gln Val His Val Ile Arg Glu Val Ala 
        275                 280                 285             


Ser Met Ala Lys Glu Lys Leu Gly Val Ser Cys Glu Val Ile Asp Leu 
    290                 295                 300                 


Arg Thr Ile Ile Pro Trp Asp Val Asp Thr Ile Cys Lys Ser Val Ile 
305                 310                 315                 320 


Lys Thr Gly Arg Leu Leu Ile Ser His Glu Ala Pro Leu Thr Gly Gly 
                325                 330                 335     


Phe Ala Ser Glu Ile Ser Ser Thr Val Gln Glu Glu Cys Phe Leu Asn 
            340                 345                 350         


Leu Glu Ala Pro Ile Ser Arg Val Cys Gly Tyr Asp Thr Pro Phe Pro 
        355                 360                 365             


His Ile Phe Glu Pro Phe Tyr Ile Pro Asp Lys Trp Lys Cys Tyr Asp 
    370                 375                 380                 


Ala Leu Arg Lys Met Ile Asn Tyr 
385                 390         


<210>  1094
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCKDK__Homo_sapiens__NP_001116429

<400>  1094

Met Ile Leu Ala Ser Val Leu Arg Ser Gly Pro Gly Gly Gly Leu Pro 
1               5                   10                  15      


Leu Arg Pro Leu Leu Gly Pro Ala Leu Ala Leu Arg Ala Arg Ser Thr 
            20                  25                  30          


Ser Ala Thr Asp Thr His His Val Glu Met Ala Arg Glu Arg Ser Lys 
        35                  40                  45              


Thr Val Thr Ser Phe Tyr Asn Gln Ser Ala Ile Asp Ala Ala Ala Glu 
    50                  55                  60                  


Lys Pro Ser Val Arg Leu Thr Pro Thr Met Met Leu Tyr Ala Gly Arg 
65                  70                  75                  80  


Ser Gln Asp Gly Ser His Leu Leu Lys Ser Ala Arg Tyr Leu Gln Gln 
                85                  90                  95      


Glu Leu Pro Val Arg Ile Ala His Arg Ile Lys Gly Phe Arg Cys Leu 
            100                 105                 110         


Pro Phe Ile Ile Gly Cys Asn Pro Thr Ile Leu His Val His Glu Leu 
        115                 120                 125             


Tyr Ile Arg Ala Phe Gln Lys Leu Thr Asp Phe Pro Pro Ile Lys Asp 
    130                 135                 140                 


Gln Ala Asp Glu Ala Gln Tyr Cys Gln Leu Val Arg Gln Leu Leu Asp 
145                 150                 155                 160 


Asp His Lys Asp Val Val Thr Leu Leu Ala Glu Gly Leu Arg Glu Ser 
                165                 170                 175     


Arg Lys His Ile Glu Asp Glu Lys Leu Val Arg Tyr Phe Leu Asp Lys 
            180                 185                 190         


Thr Leu Thr Ser Arg Leu Gly Ile Arg Met Leu Ala Thr His His Leu 
        195                 200                 205             


Ala Leu His Glu Asp Lys Pro Asp Phe Val Gly Ile Ile Cys Thr Arg 
    210                 215                 220                 


Leu Ser Pro Lys Lys Ile Ile Glu Lys Trp Val Asp Phe Ala Arg Arg 
225                 230                 235                 240 


Leu Cys Glu His Lys Tyr Gly Asn Ala Pro Arg Val Arg Ile Asn Gly 
                245                 250                 255     


His Val Ala Ala Arg Phe Pro Phe Ile Pro Met Pro Leu Asp Tyr Ile 
            260                 265                 270         


Leu Pro Glu Leu Leu Lys Asn Ala Met Arg Ala Thr Met Glu Ser His 
        275                 280                 285             


Leu Asp Thr Pro Tyr Asn Val Pro Asp Val Val Ile Thr Ile Ala Asn 
    290                 295                 300                 


Asn Asp Val Asp Leu Ile Ile Arg Ile Ser Asp Arg Gly Gly Gly Ile 
305                 310                 315                 320 


Ala His Lys Asp Leu Asp Arg Val Met Asp Tyr His Phe Thr Thr Ala 
                325                 330                 335     


Glu Ala Ser Thr Gln Asp Pro Arg Ile Ser Pro Leu Phe Gly His Leu 
            340                 345                 350         


Asp Met His Ser Gly Ala Gln Ser Gly Pro Met His Gly 
        355                 360                 365 


<210>  1095
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL10__Homo_sapiens__XP_011540701

<400>  1095

Met Ala Leu Glu Asn Leu Arg Val Tyr Leu Cys Glu Lys Ile Ile Ala 
1               5                   10                  15      


Glu Arg His Phe Asp His Leu Arg Ala Lys Lys Ile Leu Ser Arg Glu 
            20                  25                  30          


Asp Thr Glu Glu Ile Ser Cys Arg Thr Ser Ser Arg Lys Arg Ala Gly 
        35                  40                  45              


Lys Leu Leu Asp Tyr Leu Gln Glu Asn Pro Lys Gly Leu Asp Thr Leu 
    50                  55                  60                  


Val Glu Ser Ile Arg Arg Glu Lys Thr Gln Asn Phe Leu Ile Gln Lys 
65                  70                  75                  80  


Ile Thr Asp Glu Val Leu Lys Leu Arg Asn Ile Lys Leu Glu His Leu 
                85                  90                  95      


Lys Gly Leu Lys Cys Ser Ser Cys Glu Pro Phe Pro Asp Gly Ala Thr 
            100                 105                 110         


Asn Asn Leu Ser Arg Ser Asn Ser Asp Glu Ser Asn Phe Ser Glu Lys 
        115                 120                 125             


Leu Arg Ala Ser Thr Val Met Tyr His Pro Glu Gly Glu Ser Ser Thr 
    130                 135                 140                 


Thr Pro Phe Phe Ser Thr Asn Ser Ser Leu Asn Leu Pro Val Leu Glu 
145                 150                 155                 160 


Val Gly Arg Thr Glu Asn Thr Ile Phe Ser Ser Thr Thr Leu Pro Arg 
                165                 170                 175     


Pro Gly Asp Pro Gly Ala Pro Pro Leu Pro Pro Asp Leu Gln Leu Glu 
            180                 185                 190         


Glu Glu Gly Thr Cys Ala Asn Ser Ser Glu Met Phe Leu Pro Leu Arg 
        195                 200                 205             


Ser Arg Thr Val Ser Arg Gln 
    210                 215 


<210>  1096
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL11A__Homo_sapiens__NP_060484

<400>  1096

Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu 
1               5                   10                  15      


Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp 
            20                  25                  30          


His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys 
        35                  40                  45              


Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile 
    50                  55                  60                  


Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala 
65                  70                  75                  80  


Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser 
                85                  90                  95      


Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys 
            100                 105                 110         


Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala 
        115                 120                 125             


Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His 
    130                 135                 140                 


Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln 
145                 150                 155                 160 


Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys 
                165                 170                 175     


Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr 
            180                 185                 190         


His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr 
        195                 200                 205             


Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln 
    210                 215                 220                 


Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu 
225                 230                 235                 240 


Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu 
                245                 250                 255     


Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His 
            260                 265                 270         


His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala 
        275                 280                 285             


Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn 
    290                 295                 300                 


Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg 
305                 310                 315                 320 


Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro 
                325                 330                 335     


Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro 
            340                 345                 350         


Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro 
        355                 360                 365             


Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys 
    370                 375                 380                 


Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr 
385                 390                 395                 400 


Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln 
                405                 410                 415     


Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser 
            420                 425                 430         


Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro 
        435                 440                 445             


Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys 
    450                 455                 460                 


Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro 
465                 470                 475                 480 


Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp 
            500                 505                 510         


Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser 
        515                 520                 525             


Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro 
    530                 535                 540                 


Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu 
545                 550                 555                 560 


Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala 
                565                 570                 575     


Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly 
            580                 585                 590         


Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser 
        595                 600                 605             


Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly 
    610                 615                 620                 


Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys 
625                 630                 635                 640 


Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr 
                645                 650                 655     


Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro 
            660                 665                 670         


Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser 
        675                 680                 685             


Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly 
    690                 695                 700                 


Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly 
705                 710                 715                 720 


Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys 
                725                 730                 735     


Glu Gly Arg Arg Ser Asp Thr Cys Ser Ser His Thr Pro Ile Arg Arg 
            740                 745                 750         


Ser Thr Gln Arg Ala Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser 
        755                 760                 765             


Arg Ala Leu Lys Phe 
    770             


<210>  1097
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL11B__Homo_sapiens__NP_075049

<400>  1097

Met Ser Arg Arg Lys Gln Gly Asn Pro Gln His Leu Ser Gln Arg Glu 
1               5                   10                  15      


Leu Ile Thr Pro Glu Ala Asp His Val Glu Ala Ala Ile Leu Glu Glu 
            20                  25                  30          


Asp Glu Gly Leu Glu Ile Glu Glu Pro Ser Gly Leu Gly Leu Met Val 
        35                  40                  45              


Gly Gly Pro Asp Pro Asp Leu Leu Thr Cys Gly Gln Cys Gln Met Asn 
    50                  55                  60                  


Phe Pro Leu Gly Asp Ile Leu Val Phe Ile Glu His Lys Arg Lys Gln 
65                  70                  75                  80  


Cys Gly Gly Ser Leu Gly Ala Cys Tyr Asp Lys Ala Leu Asp Lys Asp 
                85                  90                  95      


Ser Pro Pro Pro Ser Ser Arg Ser Glu Leu Arg Lys Val Ser Glu Pro 
            100                 105                 110         


Val Glu Ile Gly Ile Gln Val Thr Pro Asp Glu Asp Asp His Leu Leu 
        115                 120                 125             


Ser Pro Thr Lys Gly Ile Cys Pro Lys Gln Glu Asn Ile Ala Gly Lys 
    130                 135                 140                 


Asp Glu Pro Ser Ser Tyr Ile Cys Thr Thr Cys Lys Gln Pro Phe Asn 
145                 150                 155                 160 


Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr His Gly Phe Arg 
                165                 170                 175     


Ile Tyr Leu Glu Pro Gly Pro Ala Ser Ser Ser Leu Thr Pro Arg Leu 
            180                 185                 190         


Thr Ile Pro Pro Pro Leu Gly Pro Glu Ala Val Ala Gln Ser Pro Leu 
        195                 200                 205             


Met Asn Phe Leu Gly Asp Ser Asn Pro Phe Asn Leu Leu Arg Met Thr 
    210                 215                 220                 


Gly Pro Ile Leu Arg Asp His Pro Gly Phe Gly Glu Gly Arg Leu Pro 
225                 230                 235                 240 


Gly Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His His Leu Asp Pro 
                245                 250                 255     


His Arg Leu Ser Ala Glu Glu Met Gly Leu Val Ala Gln His Pro Ser 
            260                 265                 270         


Ala Phe Asp Arg Val Met Arg Leu Asn Pro Met Ala Ile Asp Ser Pro 
        275                 280                 285             


Ala Met Asp Phe Ser Arg Arg Leu Arg Glu Leu Ala Gly Asn Ser Ser 
    290                 295                 300                 


Thr Pro Pro Pro Val Ser Pro Gly Arg Gly Asn Pro Met His Arg Leu 
305                 310                 315                 320 


Leu Asn Pro Phe Gln Pro Ser Pro Lys Ser Pro Phe Leu Ser Thr Pro 
                325                 330                 335     


Pro Leu Pro Pro Met Pro Pro Gly Gly Thr Pro Pro Pro Gln Pro Pro 
            340                 345                 350         


Ala Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys Thr Phe Lys Phe Gln 
        355                 360                 365             


Ser Asn Leu Ile Val His Arg Arg Ser His Thr Gly Glu Lys Pro Tyr 
    370                 375                 380                 


Lys Cys Gln Leu Cys Asp His Ala Cys Ser Gln Ala Ser Lys Leu Lys 
385                 390                 395                 400 


Arg His Met Lys Thr His Met His Lys Ala Gly Ser Leu Ala Gly Arg 
                405                 410                 415     


Ser Asp Asp Gly Leu Ser Ala Ala Ser Ser Pro Glu Pro Gly Thr Ser 
            420                 425                 430         


Glu Leu Ala Gly Glu Gly Leu Lys Ala Ala Asp Gly Asp Phe Arg His 
        435                 440                 445             


His Glu Ser Asp Pro Ser Leu Gly His Glu Pro Glu Glu Glu Asp Glu 
    450                 455                 460                 


Glu Glu Glu Glu Glu Glu Glu Glu Leu Leu Leu Glu Asn Glu Ser Arg 
465                 470                 475                 480 


Pro Glu Ser Ser Phe Ser Met Asp Ser Glu Leu Ser Arg Asn Arg Glu 
                485                 490                 495     


Asn Gly Gly Gly Gly Val Pro Gly Val Pro Gly Ala Gly Gly Gly Ala 
            500                 505                 510         


Ala Lys Ala Leu Ala Asp Glu Lys Ala Leu Val Leu Gly Lys Val Met 
        515                 520                 525             


Glu Asn Val Gly Leu Gly Ala Leu Pro Gln Tyr Gly Glu Leu Leu Ala 
    530                 535                 540                 


Asp Lys Gln Lys Arg Gly Ala Phe Leu Lys Arg Ala Ala Gly Gly Gly 
545                 550                 555                 560 


Asp Ala Gly Asp Asp Asp Asp Ala Gly Gly Cys Gly Asp Ala Gly Ala 
                565                 570                 575     


Gly Gly Ala Val Asn Gly Arg Gly Gly Gly Phe Ala Pro Gly Thr Glu 
            580                 585                 590         


Pro Phe Pro Gly Leu Phe Pro Arg Lys Pro Ala Pro Leu Pro Ser Pro 
        595                 600                 605             


Gly Leu Asn Ser Ala Ala Lys Arg Ile Lys Val Glu Lys Asp Leu Glu 
    610                 615                 620                 


Leu Pro Pro Ala Ala Leu Ile Pro Ser Glu Asn Val Tyr Ser Gln Trp 
625                 630                 635                 640 


Leu Val Gly Tyr Ala Ala Ser Arg His Phe Met Lys Asp Pro Phe Leu 
                645                 650                 655     


Gly Phe Thr Asp Ala Arg Gln Ser Pro Phe Ala Thr Ser Ser Glu His 
            660                 665                 670         


Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly Asp Leu 
        675                 680                 685             


Leu Asp Gly Gly Leu Ser Gly Arg Ser Gly Thr Ala Ser Gly Gly Ser 
    690                 695                 700                 


Thr Pro His Leu Gly Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys Glu 
705                 710                 715                 720 


Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys Asn 
                725                 730                 735     


Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg Pro 
            740                 745                 750         


Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys Leu 
        755                 760                 765             


Thr Arg His Met Lys Thr His Gly Gln Ile Gly Lys Glu Val Tyr Arg 
    770                 775                 780                 


Cys Asp Ile Cys Gln Met Pro Phe Ser Val Tyr Ser Thr Leu Glu Lys 
785                 790                 795                 800 


His Met Lys Lys Trp His Gly Glu His Leu Leu Thr Asn Asp Val Lys 
                805                 810                 815     


Ile Glu Gln Ala Glu Arg Ser 
            820             


<210>  1098
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2A1__Homo_sapiens__NP_001108207

<400>  1098

Met Thr Asp Cys Glu Phe Gly Tyr Ile Tyr Arg Leu Ala Gln Asp Tyr 
1               5                   10                  15      


Leu Gln Cys Val Leu Gln Ile Pro Gln Pro Gly Ser Gly Pro Ser Lys 
            20                  25                  30          


Thr Ser Arg Val Leu Gln Asn Val Ala Phe Ser Val Gln Lys Glu Val 
        35                  40                  45              


Glu Lys Asn Leu Lys Ser Cys Leu Asp Asn Val Asn Val Val Ser Val 
    50                  55                  60                  


Asp Thr Ala Arg Thr Leu Phe Asn Gln Val Met Glu Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Gly Ile Ile Asn Trp Gly Arg Ile Val Thr Ile Phe Ala Phe Glu 
                85                  90                  95      


Gly Ile Leu Ile Lys Lys Leu Leu Arg Gln Gln Ile Ala Pro Asp Val 
            100                 105                 110         


Asp Thr Tyr Lys Glu Ile Ser Tyr Phe Val Ala Glu Phe Ile Met Asn 
        115                 120                 125             


Asn Thr Gly Glu Trp Ile Arg Gln Asn Gly Gly Trp Gly Lys Trp His 
    130                 135                 140                 


Asn His Thr Pro Met Leu Val Glu Ser Val Ala His Lys Lys Arg Lys 
145                 150                 155                 160 


Met Ala Leu 
            


<210>  1099
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2__Homo_sapiens__NP_000624

<400>  1099

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  1100
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L10__Homo_sapiens__NP_065129

<400>  1100

Met Val Asp Gln Leu Arg Glu Arg Thr Thr Met Ala Asp Pro Leu Arg 
1               5                   10                  15      


Glu Arg Thr Glu Leu Leu Leu Ala Asp Tyr Leu Gly Tyr Cys Ala Arg 
            20                  25                  30          


Glu Pro Gly Thr Pro Glu Pro Ala Pro Ser Thr Pro Glu Ala Ala Val 
        35                  40                  45              


Leu Arg Ser Ala Ala Ala Arg Leu Arg Gln Ile His Arg Ser Phe Phe 
    50                  55                  60                  


Ser Ala Tyr Leu Gly Tyr Pro Gly Asn Arg Phe Glu Leu Val Ala Leu 
65                  70                  75                  80  


Met Ala Asp Ser Val Leu Ser Asp Ser Pro Gly Pro Thr Trp Gly Arg 
                85                  90                  95      


Val Val Thr Leu Val Thr Phe Ala Gly Thr Leu Leu Glu Arg Gly Pro 
            100                 105                 110         


Leu Val Thr Ala Arg Trp Lys Lys Trp Gly Phe Gln Pro Arg Leu Lys 
        115                 120                 125             


Glu Gln Glu Gly Asp Val Ala Arg Asp Cys Gln Arg Leu Val Ala Leu 
    130                 135                 140                 


Leu Ser Ser Arg Leu Met Gly Gln His Arg Ala Trp Leu Gln Ala Gln 
145                 150                 155                 160 


Gly Gly Trp Asp Gly Phe Cys His Phe Phe Arg Thr Pro Phe Pro Leu 
                165                 170                 175     


Ala Phe Trp Arg Lys Gln Leu Val Gln Ala Phe Leu Ser Cys Leu Leu 
            180                 185                 190         


Thr Thr Ala Phe Ile Tyr Leu Trp Thr Arg Leu Leu 
        195                 200                 


<210>  1101
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L11__Homo_sapiens__NP_001191036

<400>  1101

Met Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly 
1               5                   10                  15      


Arg Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala 
            20                  25                  30          


Pro Thr Ser Leu Gln Thr Glu Pro Gln Ala Ser Met Arg Gln Ala Glu 
        35                  40                  45              


Pro Ala Asp Met Arg Pro Glu Ile Trp Ile Ala Gln Glu Leu Arg Arg 
    50                  55                  60                  


Ile Gly Asp Glu Phe Asn Ala Tyr Tyr Ala Arg Arg Leu Ala Lys Leu 
65                  70                  75                  80  


Leu Ala Ser Ser Thr 
                85  


<210>  1102
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L12__Homo_sapiens__NP_001035758

<400>  1102

Met Gly Arg Pro Ala Gly Leu Phe Pro Pro Leu Cys Pro Phe Leu Gly 
1               5                   10                  15      


Phe Arg Pro Glu Ala Cys Trp Glu Arg His Met Gln Ile Glu Arg Ala 
            20                  25                  30          


Pro Ser Val Pro Pro Phe Leu Arg Trp Ala Gly Tyr Arg Pro Gly Pro 
        35                  40                  45              


Val Arg Arg Arg Gly Lys Val Glu Leu Ile Lys Phe Val Arg Val Gln 
    50                  55                  60                  


Trp Arg Arg Pro Gln Val Glu Trp Arg Arg Arg Arg Trp Gly Pro Gly 
65                  70                  75                  80  


Pro Gly Ala Ser Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp 
                85                  90                  95      


Thr Leu Arg Val Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly 
            100                 105                 110         


Ser Pro Val Pro Thr Pro Pro Ser Pro Ala Gln Glu Glu Pro Thr Asp 
        115                 120                 125             


Phe Leu Ser Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg Gly 
    130                 135                 140                 


Ala Ala Pro Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg Pro 
145                 150                 155                 160 


Cys Tyr Gly Leu Glu Pro Gly Pro Ala Thr Pro Asp Phe Tyr Ala Leu 
                165                 170                 175     


Val Ala Gln Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser Pro 
            180                 185                 190         


Pro Ser Pro Glu Leu Gln Gly Pro Pro Ser Thr Glu Lys Glu Ala Ile 
        195                 200                 205             


Leu Arg Arg Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile Asn 
    210                 215                 220                 


Gln Lys Leu Ala Ser Asp Pro Ala Leu Arg Ser Lys Leu Val Arg Leu 
225                 230                 235                 240 


Ser Ser Asp Ser Phe Ala Arg Leu Val Glu Leu Phe Cys Ser Arg Asp 
                245                 250                 255     


Asp Ser Ser Arg Pro Ser Arg Ala Cys Pro Gly Pro Pro Pro Pro Ser 
            260                 265                 270         


Pro Glu Pro Leu Ala Arg Leu Ala Leu Ala Met Glu Leu Ser Arg Arg 
        275                 280                 285             


Val Ala Gly Leu Gly Gly Thr Leu Ala Gly Leu Ser Val Glu His Val 
    290                 295                 300                 


His Ser Phe Thr Pro Trp Ile Gln Ala His Gly Gly Trp Glu Gly Ile 
305                 310                 315                 320 


Leu Ala Val Ser Pro Val Asp Leu Asn Leu Pro Leu Asp 
                325                 330             


<210>  1103
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L13__Homo_sapiens__NP_001257656

<400>  1103

Met Ser Gly Ser Ser Gly Pro Ala Pro Thr Pro Ala Val Thr Lys Ala 
1               5                   10                  15      


Arg Arg Gly Asp Leu Thr Leu Gln His Gly Gly Gly Gly Arg Leu Gly 
            20                  25                  30          


Pro Arg Val Gly Ala Leu Thr Ala Ala Gly Gly Pro Cys Arg Lys Gln 
        35                  40                  45              


Leu Pro Pro Pro Pro Leu Ser Ser Leu Leu Gly Gln Gly Pro Gly Pro 
    50                  55                  60                  


Gly Val Gln Leu Asp Ile Ala Ser Gln Ser Leu Asp Gln Glu Ile Leu 
65                  70                  75                  80  


Leu Lys Val Lys Thr Glu Ile Glu Glu Glu Leu Lys Ser Leu Asp Lys 
                85                  90                  95      


Glu Ile Ser Glu Ala Phe Thr Ser Thr Gly Phe Asp Arg His Thr Ser 
            100                 105                 110         


Pro Val Phe Ser Pro Ala Asn Pro Glu Ser Ser Met Glu Asp Cys Leu 
        115                 120                 125             


Ala His Leu Gly Glu Lys Val Ser Gln Glu Leu Lys Glu Pro Leu His 
    130                 135                 140                 


Lys Ala Leu Gln Met Leu Leu Ser Gln Pro Val Thr Tyr Gln Ala Phe 
145                 150                 155                 160 


Arg Glu Cys Thr Leu Glu Thr Thr Val His Ala Ser Gly Trp Asn Lys 
                165                 170                 175     


Gly Thr Val Phe Ser Leu Glu Ser Glu Glu Glu Glu Tyr Pro Gly Ile 
            180                 185                 190         


Thr Ala Glu Asp Ser Asn Asp Ile Tyr Ile Leu Pro Ser Asp Asn Ser 
        195                 200                 205             


Gly Gln Val Ser Pro Pro Glu Ser Pro Thr Val Thr Thr Ser Trp Gln 
    210                 215                 220                 


Ser Glu Ser Leu Pro Val Ser Leu Ser Ala Ser Gln Ser Trp His Thr 
225                 230                 235                 240 


Glu Ser Leu Pro Val Ser Leu Gly Pro Glu Ser Trp Gln Gln Ile Ala 
                245                 250                 255     


Met Asp Pro Glu Glu Val Lys Ser Leu Asp Ser Asn Gly Ala Gly Glu 
            260                 265                 270         


Lys Ser Glu Asn Asn Ser Ser Asn Ser Asp Ile Val His Val Glu Lys 
        275                 280                 285             


Glu Glu Val Pro Glu Gly Met Glu Glu Ala Ala Val Ala Ser Val Val 
    290                 295                 300                 


Leu Pro Ala Arg Glu Leu Gln Glu Ala Leu Pro Glu Ala Pro Ala Pro 
305                 310                 315                 320 


Leu Leu Pro His Ile Thr Ala Thr Ser Leu Leu Gly Thr Arg Glu Pro 
                325                 330                 335     


Asp Thr Glu Val Ile Thr Val Glu Lys Ser Ser Pro Ala Thr Ser Leu 
            340                 345                 350         


Phe Val Glu Leu Asp Glu Glu Glu Val Lys Ala Ala Thr Thr Glu Pro 
        355                 360                 365             


Thr Glu Val Glu Glu Val Val Pro Ala Leu Glu Pro Thr Glu Thr Leu 
    370                 375                 380                 


Leu Ser Glu Lys Glu Ile Asn Ala Arg Glu Glu Ser Leu Val Glu Glu 
385                 390                 395                 400 


Leu Ser Pro Ala Ser Glu Lys Lys Pro Val Pro Pro Ser Glu Gly Lys 
                405                 410                 415     


Ser Arg Leu Ser Pro Ala Gly Glu Met Lys Pro Met Pro Leu Ser Glu 
            420                 425                 430         


Gly Lys Ser Ile Leu Leu Phe Gly Gly Ala Ala Ala Val Ala Ile Leu 
        435                 440                 445             


Ala Val Ala Ile Gly Val Ala Leu Ala Leu Arg Lys Lys 
    450                 455                 460     


<210>  1104
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L14__Homo_sapiens__NP_110393

<400>  1104

Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp Asp 
1               5                   10                  15      


Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala Tyr Tyr Thr Arg 
            20                  25                  30          


His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Arg Thr Arg Ser Leu Ser Gln Arg Gly Leu Gly Asn Cys Ser Ala Asn 
    50                  55                  60                  


Glu Ser Trp Thr Glu Val Ser Trp Pro Cys Arg Asn Ser Gln Ser Ser 
65                  70                  75                  80  


Glu Lys Ala Ile Asn Leu Gly Lys Lys Lys Ser Ser Trp Lys Ala Phe 
                85                  90                  95      


Phe Gly Val Val Glu Lys Glu Asp Ser Gln Ser Thr Pro Ala Lys Val 
            100                 105                 110         


Ser Ala Gln Gly Gln Arg Thr Leu Glu Tyr Gln Asp Ser His Ser Gln 
        115                 120                 125             


Gln Trp Ser Arg Cys Leu Ser Asn Val Glu Gln Cys Leu Glu His Glu 
    130                 135                 140                 


Ala Val Asp Pro Lys Val Ile Ser Ile Ala Asn Arg Val Ala Glu Ile 
145                 150                 155                 160 


Val Tyr Ser Trp Pro Pro Pro Gln Ala Thr Gln Ala Gly Gly Phe Lys 
                165                 170                 175     


Ser Lys Glu Ile Phe Val Thr Glu Gly Leu Ser Phe Gln Leu Gln Gly 
            180                 185                 190         


His Val Pro Val Ala Ser Ser Ser Lys Lys Asp Glu Glu Glu Gln Ile 
        195                 200                 205             


Leu Ala Lys Ile Val Glu Leu Leu Lys Tyr Ser Gly Asp Gln Leu Glu 
    210                 215                 220                 


Arg Lys Asp Thr Ala Phe Ile Pro Ile Pro Leu Val Asp Thr Ser Ile 
225                 230                 235                 240 


Gln Gly Phe Pro Gln Asp Gly Leu Met Ala Cys Ile 
                245                 250         


<210>  1105
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L1__Homo_sapiens__NP_001182

<400>  1105

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Asp Thr Phe 
        115                 120                 125             


Val Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln 
    130                 135                 140                 


Glu Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val 
145                 150                 155                 160 


Val Leu Leu Gly Ser Leu Phe Ser Arg Lys 
                165                 170 


<210>  1106
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L2__Homo_sapiens__NP_004041

<400>  1106

Met Ala Thr Pro Ala Ser Ala Pro Asp Thr Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Thr Arg Phe Arg Arg Thr Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Thr Pro Gly Ser Ala Gln Gln Arg Phe Thr 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Thr Arg Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Ala Glu Phe Thr Ala Leu Tyr Gly Asp Gly Ala Leu Glu Glu Ala Arg 
145                 150                 155                 160 


Arg Leu Arg Glu Gly Asn Trp Ala Ser Val Arg Thr Val Leu Thr Gly 
                165                 170                 175     


Ala Val Ala Leu Gly Ala Leu Val Thr Val Gly Ala Phe Phe Ala Ser 
            180                 185                 190         


Lys 
    


<210>  1107
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2L2-PABPN1__Homo_sapiens__NP_001186793

<400>  1107

Met Ala Thr Pro Ala Ser Ala Pro Asp Thr Arg Ala Leu Val Ala Asp 
1               5                   10                  15      


Phe Val Gly Tyr Lys Leu Arg Gln Lys Gly Tyr Val Cys Gly Ala Gly 
            20                  25                  30          


Pro Gly Glu Gly Pro Ala Ala Asp Pro Leu His Gln Ala Met Arg Ala 
        35                  40                  45              


Ala Gly Asp Glu Phe Glu Thr Arg Phe Arg Arg Thr Phe Ser Asp Leu 
    50                  55                  60                  


Ala Ala Gln Leu His Val Thr Pro Gly Ser Ala Gln Gln Arg Phe Thr 
65                  70                  75                  80  


Gln Val Ser Asp Glu Leu Phe Gln Gly Gly Pro Asn Trp Gly Arg Leu 
                85                  90                  95      


Val Ala Phe Phe Val Phe Gly Ala Ala Leu Cys Ala Glu Ser Val Asn 
            100                 105                 110         


Lys Glu Met Glu Pro Leu Val Gly Gln Val Gln Glu Trp Met Val Ala 
        115                 120                 125             


Tyr Leu Glu Thr Arg Leu Ala Asp Trp Ile His Ser Ser Gly Gly Trp 
    130                 135                 140                 


Glu Leu Glu Ala Ile Lys Ala Arg Val Arg Glu Met Glu Glu Glu Ala 
145                 150                 155                 160 


Glu Lys Leu Lys Glu Leu Gln Asn Glu Val Glu Lys Gln Met Asn Met 
                165                 170                 175     


Ser Pro Pro Pro Gly Asn Ala Gly Pro Val Ile Met Ser Ile Glu Glu 
            180                 185                 190         


Lys Met Glu Ala Asp Ala Arg Ser Ile Tyr Val Gly Asn Val Asp Tyr 
        195                 200                 205             


Gly Ala Thr Ala Glu Glu Leu Glu Ala His Phe His Gly Cys Gly Ser 
    210                 215                 220                 


Val Asn Arg Val Thr Ile Leu Cys Asp Lys Phe Ser Gly His Pro Lys 
225                 230                 235                 240 


Gly Phe Ala Tyr Ile Glu Phe Ser Asp Lys Glu Ser Val Arg Thr Ser 
                245                 250                 255     


Leu Ala Leu Asp Glu Ser Leu Phe Arg Gly Arg Gln Ile Lys Val Ile 
            260                 265                 270         


Pro Lys Arg Thr Asn Arg Pro Gly Ile Ser Thr Thr Asp Arg Gly Phe 
        275                 280                 285             


Pro Arg Ala Arg Tyr Arg Ala Arg Thr Thr Asn Tyr Asn Ser Ser Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Ser Gly Phe Asn Ser Arg Pro Arg Gly Arg Val Tyr 
305                 310                 315                 320 


Arg Gly Arg Ala Arg Ala Thr Ser Trp Tyr Ser Pro Tyr 
                325                 330             


<210>  1108
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL3__Homo_sapiens__XP_011525499

<400>  1108

Met Pro Arg Cys Pro Ala Gly Ala Met Asp Glu Gly Pro Val Asp Leu 
1               5                   10                  15      


Arg Thr Arg Pro Lys Ala Ala Gly Leu Pro Gly Ala Ala Leu Pro Leu 
            20                  25                  30          


Arg Lys Arg Pro Leu Arg Ala Pro Ser Pro Glu Pro Ala Ala Pro Arg 
        35                  40                  45              


Gly Ala Ala Gly Leu Val Val Pro Leu Asp Pro Leu Arg Gly Gly Cys 
    50                  55                  60                  


Asp Leu Pro Ala Val Pro Gly Pro Pro His Gly Leu Ala Arg Pro Glu 
65                  70                  75                  80  


Ala Leu Tyr Tyr Pro Gly Ala Leu Leu Pro Leu Tyr Pro Thr Arg Ala 
                85                  90                  95      


Met Gly Ser Pro Phe Pro Leu Val Asn Leu Pro Thr Pro Leu Tyr Pro 
            100                 105                 110         


Met Met Cys Pro Met Glu His Pro Leu Ser Ala Asp Ile Ala Met Ala 
        115                 120                 125             


Thr Arg Ala Asp Glu Asp Gly Asp Thr Pro Leu His Ile Ala Val Val 
    130                 135                 140                 


Gln Gly Asn Leu Pro Ala Val His Arg Leu Val Asn Leu Phe Gln Gln 
145                 150                 155                 160 


Gly Gly Arg Glu Leu Asp Ile Tyr Asn Asn Leu Arg Gln Thr Pro Leu 
                165                 170                 175     


His Leu Ala Val Ile Thr Thr Leu Pro Ser Val Val Arg Leu Leu Val 
            180                 185                 190         


Thr Ala Gly Ala Ser Pro Met Ala Leu Asp Arg His Gly Gln Thr Ala 
        195                 200                 205             


Ala His Leu Ala Cys Glu His Arg Ser Pro Thr Cys Leu Arg Ala Leu 
    210                 215                 220                 


Leu Asp Ser Ala Ala Pro Gly Thr Leu Asp Leu Glu Ala Arg Asn Tyr 
225                 230                 235                 240 


Asp Gly Leu Thr Ala Leu His Val Ala Val Asn Thr Glu Cys Gln Glu 
                245                 250                 255     


Thr Val Gln Leu Leu Leu Glu Arg Gly Ala Asp Ile Asp Ala Val Asp 
            260                 265                 270         


Ile Lys Ser Gly Arg Ser Pro Leu Ile His Ala Val Glu Asn Asn Ser 
        275                 280                 285             


Leu Ser Met Val Gln Leu Leu Leu Gln His Gly Ala Asn Val Asn Ala 
    290                 295                 300                 


Gln Met Tyr Ser Gly Ser Ser Ala Leu His Ser Ala Ser Gly Arg Gly 
305                 310                 315                 320 


Leu Leu Pro Leu Val Arg Thr Leu Val Arg Ser Gly Ala Asp Ser Ser 
                325                 330                 335     


Leu Lys Asn Cys His Asn Asp Thr Pro Leu Met Val Ala Arg Ser Arg 
            340                 345                 350         


Arg Val Ile Asp Ile Leu Arg Gly Lys Ala Thr Arg Pro Ala Ser Thr 
        355                 360                 365             


Ser Gln Pro Asp Pro Ser Pro Asp Arg Ser Ala Asn Thr Ser Pro Glu 
    370                 375                 380                 


Ser Ser Ser Arg Leu Ser Ser Asn Gly Leu Leu Ser Ala Ser Pro Ser 
385                 390                 395                 400 


Ser Ser Pro Ser Gln Ser Pro Pro Arg Asp Pro Pro Gly Phe Pro Met 
                405                 410                 415     


Ala Pro Pro Asn Phe Phe Leu Pro Ser Pro Ser Pro Pro Ala Phe Leu 
            420                 425                 430         


Pro Phe Ala Gly Val Leu Arg Gly Pro Gly Arg Pro Val Pro Pro Ser 
        435                 440                 445             


Pro Ala Pro Gly Gly Ser 
    450                 


<210>  1109
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL6B__Homo_sapiens__NP_862827

<400>  1109

Met Gly Ser Pro Ala Ala Pro Glu Gly Ala Leu Gly Tyr Val Arg Glu 
1               5                   10                  15      


Phe Thr Arg His Ser Ser Asp Val Leu Gly Asn Leu Asn Glu Leu Arg 
            20                  25                  30          


Leu Arg Gly Ile Leu Thr Asp Val Thr Leu Leu Val Gly Gly Gln Pro 
        35                  40                  45              


Leu Arg Ala His Lys Ala Val Leu Ile Ala Cys Ser Gly Phe Phe Tyr 
    50                  55                  60                  


Ser Ile Phe Arg Gly Arg Ala Gly Val Gly Val Asp Val Leu Ser Leu 
65                  70                  75                  80  


Pro Gly Gly Pro Glu Ala Arg Gly Phe Ala Pro Leu Leu Asp Phe Met 
                85                  90                  95      


Tyr Thr Ser Arg Leu Arg Leu Ser Pro Ala Thr Ala Pro Ala Val Leu 
            100                 105                 110         


Ala Ala Ala Thr Tyr Leu Gln Met Glu His Val Val Gln Ala Cys His 
        115                 120                 125             


Arg Phe Ile Gln Ala Ser Tyr Glu Pro Leu Gly Ile Ser Leu Arg Pro 
    130                 135                 140                 


Leu Glu Ala Glu Pro Pro Thr Pro Pro Thr Ala Pro Pro Pro Gly Ser 
145                 150                 155                 160 


Pro Arg Arg Ser Glu Gly His Pro Asp Pro Pro Thr Glu Ser Arg Ser 
                165                 170                 175     


Cys Ser Gln Gly Pro Pro Ser Pro Ala Ser Pro Asp Pro Lys Ala Cys 
            180                 185                 190         


Asn Trp Lys Lys Tyr Lys Tyr Ile Val Leu Asn Ser Gln Ala Ser Gln 
        195                 200                 205             


Ala Gly Ser Leu Val Gly Glu Arg Ser Ser Gly Gln Pro Cys Pro Gln 
    210                 215                 220                 


Ala Arg Leu Pro Ser Gly Asp Glu Ala Ser Ser Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Glu Glu Gly Pro Ile Pro Gly Pro Gln Ser Arg 
                245                 250                 255     


Leu Ser Pro Thr Ala Ala Thr Val Gln Phe Lys Cys Gly Ala Pro Ala 
            260                 265                 270         


Ser Thr Pro Tyr Leu Leu Thr Ser Gln Ala Gln Asp Thr Ser Gly Ser 
        275                 280                 285             


Pro Ser Glu Arg Ala Arg Pro Leu Pro Gly Ser Glu Phe Phe Ser Cys 
    290                 295                 300                 


Gln Asn Cys Glu Ala Val Ala Gly Cys Ser Ser Gly Leu Asp Ser Leu 
305                 310                 315                 320 


Val Pro Gly Asp Glu Asp Lys Pro Tyr Lys Cys Gln Leu Cys Arg Ser 
                325                 330                 335     


Ser Phe Arg Tyr Lys Gly Asn Leu Ala Ser His Arg Thr Val His Thr 
            340                 345                 350         


Gly Glu Lys Pro Tyr His Cys Ser Ile Cys Gly Ala Arg Phe Asn Arg 
        355                 360                 365             


Pro Ala Asn Leu Lys Thr His Ser Arg Ile His Ser Gly Glu Lys Pro 
    370                 375                 380                 


Tyr Lys Cys Glu Thr Cys Gly Ser Arg Phe Val Gln Val Ala His Leu 
385                 390                 395                 400 


Arg Ala His Val Leu Ile His Thr Gly Glu Lys Pro Tyr Pro Cys Pro 
                405                 410                 415     


Thr Cys Gly Thr Arg Phe Arg His Leu Gln Thr Leu Lys Ser His Val 
            420                 425                 430         


Arg Ile His Thr Gly Glu Lys Pro Tyr His Cys Asp Pro Cys Gly Leu 
        435                 440                 445             


His Phe Arg His Lys Ser Gln Leu Arg Leu His Leu Arg Gln Lys His 
    450                 455                 460                 


Gly Ala Ala Thr Asn Thr Lys Val His Tyr His Ile Leu Gly Gly Pro 
465                 470                 475                 480 


<210>  1110
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL6__Homo_sapiens__NP_001124317

<400>  1110

Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             


Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 


Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 


Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu 
                165                 170                 175     


Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro 
            180                 185                 190         


Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe 
        195                 200                 205             


Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe 
    210                 215                 220                 


Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly 
225                 230                 235                 240 


Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser 
                245                 250                 255     


Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp 
            260                 265                 270         


Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala 
        275                 280                 285             


Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys 
                325                 330                 335     


Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn 
            340                 345                 350         


Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr 
        355                 360                 365             


Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn 
    370                 375                 380                 


Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu 
385                 390                 395                 400 


Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro 
                405                 410                 415     


Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser 
            420                 425                 430         


Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn 
        435                 440                 445             


Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser 
465                 470                 475                 480 


Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr 
                485                 490                 495     


Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser 
            500                 505                 510         


Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser 
        515                 520                 525             


Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn 
545                 550                 555                 560 


Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys 
                565                 570                 575     


Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His 
            580                 585                 590         


Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly 
        595                 600                 605             


Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His 
    610                 615                 620                 


Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg 
625                 630                 635                 640 


His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys 
                645                 650                 655     


Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln 
            660                 665                 670         


Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys 
        675                 680                 685             


Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys 
    690                 695                 700                 


Ala Cys 
705     


<210>  1111
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL7A__Homo_sapiens__NP_001019979

<400>  1111

Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Arg Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Tyr Lys Trp 
        35                  40                  45              


Val Pro Val Thr Glu Pro Lys Val Asp Asp Lys Asn Lys Asn Lys Lys 
    50                  55                  60                  


Lys Gly Lys Asp Glu Lys Cys Gly Ser Glu Val Thr Thr Pro Glu Asn 
65                  70                  75                  80  


Ser Ser Ser Pro Gly Met Met Asp Met His Asp Asp Asn Ser Asn Gln 
                85                  90                  95      


Ser Ser Ile Ala Asp Ala Ser Pro Ile Lys Gln Glu Asn Ser Ser Asn 
            100                 105                 110         


Ser Ser Pro Ala Pro Glu Pro Asn Ser Ala Val Pro Ser Asp Gly Thr 
        115                 120                 125             


Glu Ala Lys Val Asp Glu Ala Gln Ala Asp Gly Lys Glu His Pro Gly 
    130                 135                 140                 


Ala Glu Asp Ala Ser Asp Glu Gln Asn Ser Gln Ser Ser Met Glu His 
145                 150                 155                 160 


Ser Met Asn Ser Ser Glu Lys Val Asp Arg Gln Pro Ser Gly Asp Ser 
                165                 170                 175     


Gly Leu Ala Ala Glu Thr Ser Ala Ile Ser Gln Asp Leu Glu Gly Val 
            180                 185                 190         


Pro Pro Ser Lys Lys Met Lys Leu Glu Ala Ser Gln Gln Asn Ser Glu 
        195                 200                 205             


Glu Met 
    210 


<210>  1112
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL7B__Homo_sapiens__NP_001184173

<400>  1112

Met Ser Gly Arg Ser Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Ala Ile Glu Lys Val Arg Lys Trp Glu 
            20                  25                  30          


Lys Lys Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Thr Asp Ser Lys Glu Lys Glu Lys Ser Lys Ser Asn Ser 
    50                  55                  60                  


Ser Ala Ala Arg Glu Pro Asn Gly Phe Pro Ser Asp Ala Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Glu Phe Gln Glu Pro Ser Leu Pro Ser Ser Glu 
                85                  90                  95      


Val Ala Asp Glu Pro Pro Thr Leu Thr Lys Glu Glu Pro Val Pro Leu 
            100                 105                 110         


Glu Thr Gln Val Val Glu Glu Glu Glu Asp Ser Gly Ala Pro Pro Leu 
        115                 120                 125             


Lys Arg Phe Cys Val Asp Gln Pro Thr Val Pro Gln Thr Ala Ser Glu 
    130                 135                 140                 


Ser 
145 


<210>  1113
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL7C__Homo_sapiens__NP_001273455

<400>  1113

Met Ala Gly Arg Thr Val Arg Ala Glu Thr Arg Ser Arg Ala Lys Asp 
1               5                   10                  15      


Asp Ile Lys Lys Val Met Ala Thr Ile Glu Lys Val Arg Arg Trp Glu 
            20                  25                  30          


Lys Arg Trp Val Thr Val Gly Asp Thr Ser Leu Arg Ile Phe Lys Trp 
        35                  40                  45              


Val Pro Val Val Asp Pro Gln Glu Glu Glu Arg Arg Arg Ala Gly Gly 
    50                  55                  60                  


Gly Ala Glu Arg Ser Arg Gly Arg Glu Arg Arg Gly Arg Gly Ala Ser 
65                  70                  75                  80  


Pro Arg Gly Gly Gly Pro Leu Ile Leu Leu Asp Leu Asn Asp Glu Asn 
                85                  90                  95      


Ser Asn Gln Ser Phe His Ser Glu Gly Ser Leu Gln Lys Gly Thr Glu 
            100                 105                 110         


Pro Ser Pro Gly Gly Thr Pro Gln Pro Ser Arg Pro Val Ser Pro Ala 
        115                 120                 125             


Gly Pro Pro Glu Gly Val Pro Glu Glu Ala Gln Pro Pro Arg Leu Gly 
    130                 135                 140                 


Gln Glu Arg Asp Pro Gly Gly Ile Thr Ala Gly Ser Thr Asp Glu Pro 
145                 150                 155                 160 


Pro Met Leu Thr Lys Glu Glu Pro Val Pro Glu Leu Leu Glu Ala Glu 
                165                 170                 175     


Asp Ser Gly Val Arg Met Thr Arg Arg Ala Leu His Glu Lys Gly Leu 
            180                 185                 190         


Lys Thr Glu Pro Leu Arg Arg Leu Leu Pro Arg Arg Gly Leu Arg Thr 
        195                 200                 205             


Asn Val Arg Pro Ser Ser Met Ala Val Pro Asp Thr Arg Ala Pro Gly 
    210                 215                 220                 


Gly Gly Ser Lys Ala Pro Arg Ala Pro Arg Thr Ile Pro Gln Gly Lys 
225                 230                 235                 240 


Gly Arg 
        


<210>  1114
<211>  1499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL9L__Homo_sapiens__NP_872363

<400>  1114

Met Arg Ile Leu Ala Asn Lys Thr Arg Leu Pro His Pro Arg Arg Arg 
1               5                   10                  15      


Glu Ala Pro Gly Ser Pro Pro Leu Ser Pro Arg Gly His Cys Pro Pro 
            20                  25                  30          


Ala Pro Ala Lys Pro Met His Pro Glu Asn Lys Leu Thr Asn His Gly 
        35                  40                  45              


Lys Thr Gly Asn Gly Gly Ala Gln Ser Gln His Gln Asn Val Asn Gln 
    50                  55                  60                  


Gly Pro Thr Cys Asn Val Gly Ser Lys Gly Val Gly Ala Gly Asn His 
65                  70                  75                  80  


Gly Ala Lys Ala Asn Gln Ile Ser Pro Ser Asn Ser Ser Leu Lys Asn 
                85                  90                  95      


Pro Gln Ala Gly Val Pro Pro Phe Ser Ser Leu Lys Gly Lys Val Lys 
            100                 105                 110         


Arg Asp Arg Ser Val Ser Val Asp Ser Gly Glu Gln Arg Glu Ala Gly 
        115                 120                 125             


Thr Pro Ser Leu Asp Ser Glu Ala Lys Glu Val Ala Pro Arg Ser Lys 
    130                 135                 140                 


Arg Arg Cys Val Leu Glu Arg Lys Gln Pro Tyr Ser Gly Asp Glu Trp 
145                 150                 155                 160 


Cys Ser Gly Pro Asp Ser Glu Glu Asp Asp Lys Pro Ile Gly Ala Thr 
                165                 170                 175     


His Asn Cys Asn Val Ala Asp Pro Ala Met Ala Ala Pro Gln Leu Gly 
            180                 185                 190         


Pro Gly Gln Thr Thr Gln Leu Pro Leu Ser Glu Ser Ser Val Pro Gly 
        195                 200                 205             


Ala Pro His Gly Pro Pro Pro Gly Leu Arg Pro Asp Ala Pro Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Val Pro Gly Lys Pro Pro Ser Gln Phe Val 
225                 230                 235                 240 


Tyr Val Phe Thr Thr His Leu Ala Asn Thr Ala Ala Glu Ala Val Leu 
                245                 250                 255     


Gln Gly Arg Ala Asp Ser Ile Leu Ala Tyr His Gln Gln Asn Val Pro 
            260                 265                 270         


Arg Ala Lys Leu Asp Gln Ala Pro Lys Val Pro Pro Thr Pro Glu Pro 
        275                 280                 285             


Leu Pro Leu Ser Thr Pro Ser Ala Gly Thr Pro Gln Ser Gln Pro Pro 
    290                 295                 300                 


Pro Leu Pro Pro Pro Pro Pro Pro Ala Pro Gly Ser Ala Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Pro Glu Gly Pro Pro Glu Asp Ser Ser Gln Asp Leu Ala Pro 
                325                 330                 335     


Asn Ser Val Gly Ala Ala Ser Thr Gly Gly Gly Thr Gly Gly Thr His 
            340                 345                 350         


Pro Asn Thr Pro Thr Ala Thr Thr Ala Asn Asn Pro Leu Pro Pro Gly 
        355                 360                 365             


Gly Asp Pro Ser Ser Ala Pro Gly Pro Ala Leu Leu Gly Glu Ala Ala 
    370                 375                 380                 


Ala Pro Gly Asn Gly Gln Arg Ser Leu Val Gly Ser Glu Gly Leu Ser 
385                 390                 395                 400 


Lys Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu Arg Asp 
                405                 410                 415     


Ile Glu Arg Leu Leu Leu Arg Ser Gly Glu Thr Glu Pro Phe Leu Lys 
            420                 425                 430         


Gly Pro Pro Gly Gly Ala Gly Glu Gly Gly Pro Pro Ala Gln Ala Pro 
        435                 440                 445             


Pro Pro Pro Gln Gln Pro Pro Thr Ala Pro Pro Ser Gly Leu Lys Lys 
    450                 455                 460                 


Tyr Glu Glu Pro Leu Gln Ser Met Ile Ser Gln Thr Gln Ser Leu Gly 
465                 470                 475                 480 


Gly Pro Pro Leu Glu His Glu Val Pro Gly His Pro Pro Gly Gly Asp 
                485                 490                 495     


Met Gly Gln Gln Met Asn Met Met Ile Gln Arg Leu Gly Gln Asp Ser 
            500                 505                 510         


Leu Thr Pro Glu Gln Val Ala Trp Arg Lys Leu Gln Glu Glu Tyr Tyr 
        515                 520                 525             


Glu Glu Lys Arg Arg Lys Glu Glu Gln Ile Gly Leu His Gly Ser Arg 
    530                 535                 540                 


Pro Leu Gln Asp Met Met Gly Met Gly Gly Met Met Val Arg Gly Pro 
545                 550                 555                 560 


Pro Pro Pro Tyr His Ser Lys Pro Gly Asp Gln Trp Pro Pro Gly Met 
                565                 570                 575     


Gly Ala Gln Leu Arg Gly Pro Met Asp Val Gln Asp Pro Met Gln Leu 
            580                 585                 590         


Arg Gly Gly Pro Pro Phe Pro Gly Pro Arg Phe Pro Gly Asn Gln Ile 
        595                 600                 605             


Gln Arg Val Pro Gly Phe Gly Gly Met Gln Ser Met Pro Met Glu Val 
    610                 615                 620                 


Pro Met Asn Ala Met Gln Arg Pro Val Arg Pro Gly Met Gly Trp Thr 
625                 630                 635                 640 


Glu Asp Leu Pro Pro Met Gly Gly Pro Ser Asn Phe Ala Gln Asn Thr 
                645                 650                 655     


Met Pro Tyr Pro Gly Gly Gln Gly Glu Ala Glu Arg Phe Met Thr Pro 
            660                 665                 670         


Arg Val Arg Glu Glu Leu Leu Arg His Gln Leu Leu Glu Lys Arg Ser 
        675                 680                 685             


Met Gly Met Gln Arg Pro Leu Gly Met Ala Gly Ser Gly Met Gly Gln 
    690                 695                 700                 


Ser Met Glu Met Glu Arg Met Met Gln Ala His Arg Gln Met Asp Pro 
705                 710                 715                 720 


Ala Met Phe Pro Gly Gln Met Ala Gly Gly Glu Gly Leu Ala Gly Thr 
                725                 730                 735     


Pro Met Gly Met Glu Phe Gly Gly Gly Arg Gly Leu Leu Ser Pro Pro 
            740                 745                 750         


Met Gly Gln Ser Gly Leu Arg Glu Val Asp Pro Pro Met Gly Pro Gly 
        755                 760                 765             


Asn Leu Asn Met Asn Met Asn Val Asn Met Asn Met Asn Met Asn Leu 
    770                 775                 780                 


Asn Val Gln Met Thr Pro Gln Gln Gln Met Leu Met Ser Gln Lys Met 
785                 790                 795                 800 


Arg Gly Pro Gly Asp Leu Met Gly Pro Gln Gly Leu Ser Pro Glu Glu 
                805                 810                 815     


Met Ala Arg Val Arg Ala Gln Asn Ser Ser Gly Val Met Gly Gly Pro 
            820                 825                 830         


Gln Lys Met Leu Met Pro Ser Gln Phe Pro Asn Gln Gly Gln Gln Gly 
        835                 840                 845             


Phe Ser Gly Gly Gln Gly Pro Tyr Gln Ala Met Ser Gln Asp Met Gly 
    850                 855                 860                 


Asn Thr Gln Asp Met Phe Ser Pro Asp Gln Ser Ser Met Pro Met Ser 
865                 870                 875                 880 


Asn Val Gly Thr Thr Arg Leu Ser His Met Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Asn Pro Pro Gly Thr Val His Ser Ala Pro Asn Arg Gly Leu Gly Arg 
            900                 905                 910         


Arg Pro Ser Asp Leu Thr Ile Ser Ile Asn Gln Met Gly Ser Pro Gly 
        915                 920                 925             


Met Gly His Leu Lys Ser Pro Thr Leu Ser Gln Val His Ser Pro Leu 
    930                 935                 940                 


Val Thr Ser Pro Ser Ala Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln 
945                 950                 955                 960 


Met Val Pro Leu Pro Ser Ala Asn Pro Pro Gly Pro Leu Lys Ser Pro 
                965                 970                 975     


Gln Val Leu Gly Ser Ser Leu Ser Val Arg Ser Pro Thr Gly Ser Pro 
            980                 985                 990         


Ser Arg Leu Lys Ser Pro Ser Met  Ala Val Pro Ser Pro  Gly Trp Val 
        995                 1000                 1005             


Ala Ser  Pro Lys Thr Ala Met  Pro Ser Pro Gly Val  Ser Gln Asn 
    1010                 1015                 1020             


Lys Gln  Pro Pro Leu Asn Met  Asn Ser Ser Thr Thr  Leu Ser Asn 
    1025                 1030                 1035             


Met Glu  Gln Gly Thr Leu Pro  Pro Ser Gly Pro Arg  Ser Ser Ser 
    1040                 1045                 1050             


Ser Ala  Pro Pro Ala Asn Pro  Pro Ser Gly Leu Met  Asn Pro Ser 
    1055                 1060                 1065             


Leu Pro  Phe Thr Ser Ser Pro  Asp Pro Thr Pro Ser  Gln Asn Pro 
    1070                 1075                 1080             


Leu Ser  Leu Met Met Thr Gln  Met Ser Lys Tyr Ala  Met Pro Ser 
    1085                 1090                 1095             


Ser Thr  Pro Leu Tyr His Asn  Ala Ile Lys Thr Ile  Ala Thr Ser 
    1100                 1105                 1110             


Asp Asp  Glu Leu Leu Pro Asp  Arg Pro Leu Leu Pro  Pro Pro Pro 
    1115                 1120                 1125             


Pro Pro  Gln Gly Ser Gly Pro  Gly Ile Ser Asn Ser  Gln Pro Ser 
    1130                 1135                 1140             


Gln Met  His Leu Asn Ser Ala  Ala Ala Gln Ser Pro  Met Gly Met 
    1145                 1150                 1155             


Asn Leu  Pro Gly Gln Gln Pro  Leu Ser His Glu Pro  Pro Pro Ala 
    1160                 1165                 1170             


Met Leu  Pro Ser Pro Thr Pro  Leu Gly Ser Asn Ile  Pro Leu His 
    1175                 1180                 1185             


Pro Asn  Ala Gln Gly Thr Gly  Gly Pro Pro Gln Asn  Ser Met Met 
    1190                 1195                 1200             


Met Ala  Pro Gly Gly Pro Asp  Ser Leu Asn Ala Pro  Cys Gly Pro 
    1205                 1210                 1215             


Val Pro  Ser Ser Ser Gln Met  Met Pro Phe Pro Pro  Arg Leu Gln 
    1220                 1225                 1230             


Gln Pro  His Gly Ala Met Ala  Pro Thr Gly Gly Gly  Gly Gly Gly 
    1235                 1240                 1245             


Pro Gly  Leu Gln Gln His Tyr  Pro Ser Gly Met Ala  Leu Pro Pro 
    1250                 1255                 1260             


Glu Asp  Leu Pro Asn Gln Pro  Pro Gly Pro Met Pro  Pro Gln Gln 
    1265                 1270                 1275             


His Leu  Met Gly Lys Ala Met  Ala Gly Arg Met Gly  Asp Ala Tyr 
    1280                 1285                 1290             


Pro Pro  Gly Val Leu Pro Gly  Val Ala Ser Val Leu  Asn Asp Pro 
    1295                 1300                 1305             


Glu Leu  Ser Glu Val Ile Arg  Pro Thr Pro Thr Gly  Ile Pro Glu 
    1310                 1315                 1320             


Phe Asp  Leu Ser Arg Ile Ile  Pro Ser Glu Lys Pro  Ser Ser Thr 
    1325                 1330                 1335             


Leu Gln  Tyr Phe Pro Lys Ser  Glu Asn Gln Pro Pro  Lys Ala Gln 
    1340                 1345                 1350             


Pro Pro  Asn Leu His Leu Met  Asn Leu Gln Asn Met  Met Ala Glu 
    1355                 1360                 1365             


Gln Thr  Pro Ser Arg Pro Pro  Asn Leu Pro Gly Gln  Gln Gly Val 
    1370                 1375                 1380             


Gln Arg  Gly Leu Asn Met Ser  Met Cys His Pro Gly  Gln Met Ser 
    1385                 1390                 1395             


Leu Leu  Gly Arg Thr Gly Val  Pro Pro Gln Gln Gly  Met Val Pro 
    1400                 1405                 1410             


His Gly  Leu His Gln Gly Val  Met Ser Pro Pro Gln  Gly Leu Met 
    1415                 1420                 1425             


Thr Gln  Gln Asn Phe Met Leu  Met Lys Gln Arg Gly  Val Gly Gly 
    1430                 1435                 1440             


Glu Val  Tyr Ser Gln Pro Pro  His Met Leu Ser Pro  Gln Gly Ser 
    1445                 1450                 1455             


Leu Met  Gly Pro Pro Pro Gln  Gln Asn Leu Met Val  Ser His Pro 
    1460                 1465                 1470             


Leu Arg  Gln Arg Ser Val Ser  Leu Asp Ser Gln Met  Gly Tyr Leu 
    1475                 1480                 1485             


Pro Ala  Pro Gly Gly Met Ala  Asn Leu Pro Phe 
    1490                 1495                 


<210>  1115
<211>  869
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCLAF1__Homo_sapiens__NP_001070908

<400>  1115

Met Gly Arg Ser Asn Ser Arg Ser His Ser Ser Arg Ser Lys Ser Arg 
1               5                   10                  15      


Ser Gln Ser Ser Ser Arg Ser Arg Ser Arg Ser His Ser Arg Lys Lys 
            20                  25                  30          


Arg Tyr Arg Ser Arg Ser Arg Thr Tyr Ser Arg Ser Arg Ser Arg Asp 
        35                  40                  45              


Arg Met Tyr Ser Arg Asp Tyr Arg Arg Asp Tyr Arg Asn Asn Arg Gly 
    50                  55                  60                  


Met Arg Arg Pro Tyr Gly Tyr Arg Gly Arg Gly Arg Gly Tyr Tyr Gln 
65                  70                  75                  80  


Gly Gly Gly Gly Arg Tyr His Arg Gly Gly Tyr Arg Pro Val Trp Asn 
                85                  90                  95      


Arg Arg His Ser Arg Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg Ser 
            100                 105                 110         


Pro Lys Arg Arg Ser Val Ser Ser Gln Arg Ser Arg Ser Arg Ser Arg 
        115                 120                 125             


Arg Ser Tyr Arg Ser Ser Arg Ser Pro Arg Ser Ser Ser Ser Arg Ser 
    130                 135                 140                 


Ser Ser Pro Tyr Ser Lys Ser Pro Val Ser Lys Arg Arg Gly Ser Gln 
145                 150                 155                 160 


Glu Lys Gln Thr Lys Lys Ala Glu Gly Glu Pro Gln Glu Glu Ser Pro 
                165                 170                 175     


Leu Lys Ser Lys Ser Gln Glu Glu Pro Lys Asp Thr Phe Glu His Asp 
            180                 185                 190         


Pro Ser Glu Ser Ile Asp Glu Phe Asn Lys Ser Ser Ala Thr Ser Gly 
        195                 200                 205             


Asp Ile Trp Pro Gly Leu Ser Ala Tyr Asp Asn Ser Pro Arg Ser Pro 
    210                 215                 220                 


His Ser Pro Ser Pro Ile Ala Thr Pro Pro Ser Gln Ser Ser Ser Cys 
225                 230                 235                 240 


Ser Asp Ala Pro Met Leu Ser Thr Val His Ser Ala Lys Asn Thr Pro 
                245                 250                 255     


Ser Gln His Ser His Ser Ile Gln His Ser Pro Glu Arg Ser Gly Ser 
            260                 265                 270         


Gly Ser Val Gly Asn Gly Ser Ser Arg Tyr Ser Pro Ser Gln Asn Ser 
        275                 280                 285             


Pro Ile His His Ile Pro Ser Arg Arg Ser Pro Ala Lys Thr Ile Ala 
    290                 295                 300                 


Pro Gln Asn Ala Pro Arg Asp Glu Ser Arg Gly Arg Ser Ser Phe Tyr 
305                 310                 315                 320 


Pro Asp Gly Gly Asp Gln Glu Thr Ala Lys Thr Gly Lys Phe Leu Lys 
                325                 330                 335     


Arg Phe Thr Asp Glu Glu Ser Arg Val Phe Leu Leu Asp Arg Gly Asn 
            340                 345                 350         


Thr Arg Asp Lys Glu Ala Ser Lys Glu Lys Gly Ser Glu Lys Gly Arg 
        355                 360                 365             


Ala Glu Gly Glu Trp Glu Asp Gln Glu Ala Leu Asp Tyr Phe Ser Asp 
    370                 375                 380                 


Lys Glu Ser Gly Lys Gln Lys Phe Asn Asp Ser Glu Gly Asp Asp Thr 
385                 390                 395                 400 


Glu Glu Thr Glu Asp Tyr Arg Gln Phe Arg Lys Ser Val Leu Ala Asp 
                405                 410                 415     


Gln Gly Lys Ser Phe Ala Thr Ala Ser His Arg Asn Thr Glu Glu Glu 
            420                 425                 430         


Gly Leu Lys Tyr Lys Ser Lys Val Ser Leu Lys Gly Asn Arg Glu Ser 
        435                 440                 445             


Asp Gly Phe Arg Glu Glu Lys Asn Tyr Lys Leu Lys Glu Thr Gly Tyr 
    450                 455                 460                 


Val Val Glu Arg Pro Ser Thr Thr Lys Asp Lys His Lys Glu Glu Asp 
465                 470                 475                 480 


Lys Asn Ser Glu Arg Ile Thr Val Lys Lys Glu Thr Gln Ser Pro Glu 
                485                 490                 495     


Gln Val Lys Ser Glu Lys Leu Lys Asp Leu Phe Asp Tyr Ser Pro Pro 
            500                 505                 510         


Leu His Lys Asn Leu Asp Ala Arg Glu Lys Ser Thr Phe Arg Glu Glu 
        515                 520                 525             


Ser Pro Leu Arg Ile Lys Met Ile Ala Ser Asp Ser His Arg Pro Glu 
    530                 535                 540                 


Val Lys Leu Lys Met Ala Pro Val Pro Leu Asp Asp Ser Asn Arg Pro 
545                 550                 555                 560 


Ala Ser Leu Thr Lys Asp Arg Leu Leu Ala Ser Thr Leu Val His Ser 
                565                 570                 575     


Val Lys Lys Glu Gln Glu Phe Arg Ser Ile Phe Asp His Ile Lys Leu 
            580                 585                 590         


Pro Gln Ala Ser Lys Ser Thr Ser Glu Ser Phe Ile Gln His Ile Val 
        595                 600                 605             


Ser Leu Val His His Val Lys Glu Gln Tyr Phe Lys Ser Ala Ala Met 
    610                 615                 620                 


Thr Leu Asn Glu Arg Phe Thr Ser Tyr Gln Lys Ala Thr Glu Glu His 
625                 630                 635                 640 


Ser Thr Arg Gln Lys Ser Pro Glu Ile His Arg Arg Ile Asp Ile Ser 
                645                 650                 655     


Pro Ser Thr Leu Arg Lys His Thr Arg Leu Ala Gly Glu Glu Arg Val 
            660                 665                 670         


Phe Lys Glu Glu Asn Gln Lys Gly Asp Lys Lys Leu Arg Cys Asp Ser 
        675                 680                 685             


Ala Asp Leu Arg His Asp Ile Asp Arg Arg Arg Lys Glu Arg Ser Lys 
    690                 695                 700                 


Glu Arg Gly Asp Ser Lys Gly Ser Arg Glu Ser Ser Gly Ser Arg Lys 
705                 710                 715                 720 


Gln Glu Lys Thr Pro Lys Asp Tyr Lys Glu Tyr Lys Ser Tyr Lys Asp 
                725                 730                 735     


Asp Ser Lys His Lys Arg Glu Gln Asp His Ser Arg Ser Ser Ser Ser 
            740                 745                 750         


Ser Ala Ser Pro Ser Ser Pro Ser Ser Arg Glu Glu Lys Glu Ser Lys 
        755                 760                 765             


Lys Glu Arg Glu Glu Glu Phe Lys Thr His His Glu Met Lys Glu Tyr 
    770                 775                 780                 


Ser Gly Phe Ala Gly Val Ser Arg Pro Arg Gly Thr Phe His Asp Asp 
785                 790                 795                 800 


Arg Asp Asp Gly Val Asp Tyr Trp Ala Lys Arg Gly Arg Gly Arg Gly 
                805                 810                 815     


Thr Phe Gln Arg Gly Arg Gly Arg Phe Asn Phe Lys Lys Ser Gly Ser 
            820                 825                 830         


Ser Pro Lys Trp Thr His Asp Lys Tyr Gln Gly Asp Gly Ile Val Glu 
        835                 840                 845             


Asp Glu Glu Glu Thr Met Glu Asn Asn Glu Glu Lys Lys Asp Arg Arg 
    850                 855                 860                 


Lys Glu Glu Lys Glu 
865                 


<210>  1116
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCO1__Homo_sapiens__NP_059125

<400>  1116

Met Asp Ile Ile Phe Gly Arg Asn Arg Lys Glu Gln Leu Glu Pro Val 
1               5                   10                  15      


Arg Ala Lys Val Thr Gly Lys Ile Pro Ala Trp Leu Gln Gly Thr Leu 
            20                  25                  30          


Leu Arg Asn Gly Pro Gly Met His Thr Val Gly Glu Ser Arg Tyr Asn 
        35                  40                  45              


His Trp Phe Asp Gly Leu Ala Leu Leu His Ser Phe Thr Ile Arg Asp 
    50                  55                  60                  


Gly Glu Val Tyr Tyr Arg Ser Lys Tyr Leu Arg Ser Asp Thr Tyr Asn 
65                  70                  75                  80  


Thr Asn Ile Glu Ala Asn Arg Ile Val Val Ser Glu Phe Gly Thr Met 
                85                  90                  95      


Ala Tyr Pro Asp Pro Cys Lys Asn Ile Phe Ser Lys Ala Phe Ser Tyr 
            100                 105                 110         


Leu Ser His Thr Ile Pro Asp Phe Thr Asp Asn Cys Leu Ile Asn Ile 
        115                 120                 125             


Met Lys Cys Gly Glu Asp Phe Tyr Ala Thr Ser Glu Thr Asn Tyr Ile 
    130                 135                 140                 


Arg Lys Ile Asn Pro Gln Thr Leu Glu Thr Leu Glu Lys Val Asp Tyr 
145                 150                 155                 160 


Arg Lys Tyr Val Ala Val Asn Leu Ala Thr Ser His Pro His Tyr Asp 
                165                 170                 175     


Glu Ala Gly Asn Val Leu Asn Met Gly Thr Ser Ile Val Glu Lys Gly 
            180                 185                 190         


Lys Thr Lys Tyr Val Ile Phe Lys Ile Pro Ala Thr Val Pro Glu Gly 
        195                 200                 205             


Lys Lys Gln Gly Lys Ser Pro Trp Lys His Thr Glu Val Phe Cys Ser 
    210                 215                 220                 


Ile Pro Ser Arg Ser Leu Leu Ser Pro Ser Tyr Tyr His Ser Phe Gly 
225                 230                 235                 240 


Val Thr Glu Asn Tyr Val Ile Phe Leu Glu Gln Pro Phe Arg Leu Asp 
                245                 250                 255     


Ile Leu Lys Met Ala Thr Ala Tyr Ile Arg Arg Met Ser Trp Ala Ser 
            260                 265                 270         


Cys Leu Ala Phe His Arg Glu Glu Lys Thr Tyr Ile His Ile Ile Asp 
        275                 280                 285             


Gln Arg Thr Arg Gln Pro Val Gln Thr Lys Phe Tyr Thr Asp Ala Met 
    290                 295                 300                 


Val Val Phe His His Val Asn Ala Tyr Glu Glu Asp Gly Cys Ile Val 
305                 310                 315                 320 


Phe Asp Val Ile Ala Tyr Glu Asp Asn Ser Leu Tyr Gln Leu Phe Tyr 
                325                 330                 335     


Leu Ala Asn Leu Asn Gln Asp Phe Lys Glu Asn Ser Arg Leu Thr Ser 
            340                 345                 350         


Val Pro Thr Leu Arg Arg Phe Ala Val Pro Leu His Val Asp Lys Asn 
        355                 360                 365             


Ala Glu Val Gly Thr Asn Leu Ile Lys Val Ala Ser Thr Thr Ala Thr 
    370                 375                 380                 


Ala Leu Lys Glu Glu Asp Gly Gln Val Tyr Cys Gln Pro Glu Phe Leu 
385                 390                 395                 400 


Tyr Glu Gly Leu Glu Leu Pro Arg Val Asn Tyr Ala His Asn Gly Lys 
                405                 410                 415     


Gln Tyr Arg Tyr Val Phe Ala Thr Gly Val Gln Trp Ser Pro Ile Pro 
            420                 425                 430         


Thr Lys Ile Ile Lys Tyr Asp Ile Leu Thr Lys Ser Ser Leu Lys Trp 
        435                 440                 445             


Arg Glu Asp Asp Cys Trp Pro Ala Glu Pro Leu Phe Val Pro Ala Pro 
    450                 455                 460                 


Gly Ala Lys Asp Glu Asp Asp Gly Val Ile Leu Ser Ala Ile Val Ser 
465                 470                 475                 480 


Thr Asp Pro Gln Lys Leu Pro Phe Leu Leu Ile Leu Asp Ala Lys Ser 
                485                 490                 495     


Phe Thr Glu Leu Ala Arg Ala Ser Val Asp Val Asp Met His Met Asp 
            500                 505                 510         


Leu His Gly Leu Phe Ile Thr Asp Met Asp Trp Asp Thr Lys Lys Gln 
        515                 520                 525             


Ala Ala Ser Glu Glu Gln Arg Asp Arg Ala Ser Asp Cys His Gly Ala 
    530                 535                 540                 


Pro Leu Thr 
545         


<210>  1117
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCO2__Homo_sapiens__NP_001243326

<400>  1117

Met Gly Asn Thr Pro Gln Lys Lys Ala Val Phe Gly Gln Cys Arg Gly 
1               5                   10                  15      


Leu Pro Cys Val Ala Pro Leu Leu Thr Thr Val Glu Glu Ala Pro Arg 
            20                  25                  30          


Gly Ile Ser Ala Arg Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly 
        35                  40                  45              


Ser Leu Leu Arg Ile Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys 
    50                  55                  60                  


Tyr Asn His Trp Phe Asp Gly Met Ala Leu Leu His Gln Phe Arg Met 
65                  70                  75                  80  


Ala Lys Gly Thr Val Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr 
                85                  90                  95      


Tyr Lys Ala Asn Ser Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly 
            100                 105                 110         


Thr Leu Ala Leu Pro Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met 
        115                 120                 125             


Ser Arg Phe Glu Leu Pro Gly Lys Ala Ala Ala Met Thr Asp Asn Thr 
    130                 135                 140                 


Asn Val Asn Tyr Val Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys Thr Glu 
145                 150                 155                 160 


Thr Asn Phe Met Asn Lys Val Asp Ile Glu Thr Leu Glu Lys Thr Glu 
                165                 170                 175     


Lys Val Asp Trp Ser Lys Phe Ile Ala Val Asn Gly Ala Thr Ala His 
            180                 185                 190         


Pro His Tyr Asp Pro Asp Gly Thr Ala Tyr Asn Met Gly Asn Ser Phe 
        195                 200                 205             


Gly Pro Tyr Gly Phe Ser Tyr Lys Val Ile Arg Val Pro Pro Glu Lys 
    210                 215                 220                 


Val Asp Leu Gly Glu Thr Ile His Gly Val Gln Val Ile Cys Ser Ile 
225                 230                 235                 240 


Ala Ser Thr Glu Lys Gly Lys Pro Ser Tyr Tyr His Ser Phe Gly Met 
                245                 250                 255     


Thr Arg Asn Tyr Ile Ile Phe Ile Glu Gln Pro Leu Lys Met Asn Leu 
            260                 265                 270         


Trp Lys Ile Ala Thr Ser Lys Ile Arg Gly Lys Ala Phe Ser Asp Gly 
        275                 280                 285             


Ile Ser Trp Glu Pro Gln Cys Asn Thr Arg Phe His Val Val Glu Lys 
    290                 295                 300                 


Arg Thr Gly Gln Leu Leu Pro Gly Arg Tyr Tyr Ser Lys Pro Phe Val 
305                 310                 315                 320 


Thr Phe His Gln Ile Asn Ala Phe Glu Asp Gln Gly Cys Val Ile Ile 
                325                 330                 335     


Asp Leu Cys Cys Gln Asp Asn Gly Arg Thr Leu Glu Val Tyr Gln Leu 
            340                 345                 350         


Gln Asn Leu Arg Lys Ala Gly Glu Gly Leu Asp Gln Val His Asn Ser 
        355                 360                 365             


Ala Ala Lys Ser Phe Pro Arg Arg Phe Val Leu Pro Leu Asn Val Ser 
    370                 375                 380                 


Leu Asn Ala Pro Glu Gly Asp Asn Leu Ser Pro Leu Ser Tyr Thr Ser 
385                 390                 395                 400 


Ala Ser Ala Val Lys Gln Ala Asp Gly Thr Ile Trp Cys Ser His Glu 
                405                 410                 415     


Asn Leu His Gln Glu Asp Leu Glu Lys Glu Gly Gly Ile Glu Phe Pro 
            420                 425                 430         


Gln Ile Tyr Tyr Asp Arg Phe Ser Gly Lys Lys Tyr His Phe Phe Tyr 
        435                 440                 445             


Gly Cys Gly Phe Arg His Leu Val Gly Asp Ser Leu Ile Lys Val Asp 
    450                 455                 460                 


Val Val Trp Arg Glu Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe Val 
465                 470                 475                 480 


Pro Ala Pro Gly Thr Asn Glu Glu Asp Gly Gly Val Ile Leu Ser Val 
                485                 490                 495     


Val Ile Thr Pro Asn Gln Asn Glu Ser Asn Phe Leu Leu Val Leu Asp 
            500                 505                 510         


Ala Lys Asn Phe Glu Glu Leu Gly Arg Ala Glu Val Pro Val Gln Met 
        515                 520                 525             


Pro Tyr Gly Phe His Gly Thr Phe Ile Pro Ile 
    530                 535                 


<210>  1118
<211>  1721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCOR__Homo_sapiens__NP_001116855

<400>  1118

Met Leu Ser Ala Thr Pro Leu Tyr Gly Asn Val His Ser Trp Met Asn 
1               5                   10                  15      


Ser Glu Arg Val Arg Met Cys Gly Ala Ser Glu Asp Arg Lys Ile Leu 
            20                  25                  30          


Val Asn Asp Gly Asp Ala Ser Lys Ala Arg Leu Glu Leu Arg Glu Glu 
        35                  40                  45              


Asn Pro Leu Asn His Asn Val Val Asp Ala Ser Thr Ala His Arg Ile 
    50                  55                  60                  


Asp Gly Leu Ala Ala Leu Ser Met Asp Arg Thr Gly Leu Ile Arg Glu 
65                  70                  75                  80  


Gly Leu Arg Val Pro Gly Asn Ile Val Tyr Ser Ser Leu Cys Gly Leu 
                85                  90                  95      


Gly Ser Glu Lys Gly Arg Glu Ala Ala Thr Ser Thr Leu Gly Gly Leu 
            100                 105                 110         


Gly Phe Ser Ser Glu Arg Asn Pro Glu Met Gln Phe Lys Pro Asn Thr 
        115                 120                 125             


Pro Glu Thr Val Glu Ala Ser Ala Val Ser Gly Lys Pro Pro Asn Gly 
    130                 135                 140                 


Phe Ser Ala Ile Tyr Lys Thr Pro Pro Gly Ile Gln Lys Ser Ala Val 
145                 150                 155                 160 


Ala Thr Ala Glu Ala Leu Gly Leu Asp Arg Pro Ala Ser Asp Lys Gln 
                165                 170                 175     


Ser Pro Leu Asn Ile Asn Gly Ala Ser Tyr Leu Arg Leu Pro Trp Val 
            180                 185                 190         


Asn Pro Tyr Met Glu Gly Ala Thr Pro Ala Ile Tyr Pro Phe Leu Asp 
        195                 200                 205             


Ser Pro Asn Lys Tyr Ser Leu Asn Met Tyr Lys Ala Leu Leu Pro Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Leu Ala Gln Pro Leu Tyr Ser Pro Val Cys Thr Asn 
225                 230                 235                 240 


Gly Glu Arg Phe Leu Tyr Leu Pro Pro Pro His Tyr Val Gly Pro His 
                245                 250                 255     


Ile Pro Ser Ser Leu Ala Ser Pro Met Arg Leu Ser Thr Pro Ser Ala 
            260                 265                 270         


Ser Pro Ala Ile Pro Pro Leu Val His Cys Ala Asp Lys Ser Leu Pro 
        275                 280                 285             


Trp Lys Met Gly Val Ser Pro Gly Asn Pro Val Asp Ser His Ala Tyr 
    290                 295                 300                 


Pro His Ile Gln Asn Ser Lys Gln Pro Arg Val Pro Ser Ala Lys Ala 
305                 310                 315                 320 


Val Thr Ser Gly Leu Pro Gly Asp Thr Ala Leu Leu Leu Pro Pro Ser 
                325                 330                 335     


Pro Arg Pro Ser Pro Arg Val His Leu Pro Thr Gln Pro Ala Ala Asp 
            340                 345                 350         


Thr Tyr Ser Glu Phe His Lys His Tyr Ala Arg Ile Ser Thr Ser Pro 
        355                 360                 365             


Ser Val Ala Leu Ser Lys Pro Tyr Met Thr Val Ser Ser Glu Phe Pro 
    370                 375                 380                 


Ala Ala Arg Leu Ser Asn Gly Lys Tyr Pro Lys Ala Pro Glu Gly Gly 
385                 390                 395                 400 


Glu Gly Ala Gln Pro Val Pro Gly His Ala Arg Lys Thr Ala Val Gln 
                405                 410                 415     


Asp Arg Lys Asp Gly Ser Ser Pro Pro Leu Leu Glu Lys Gln Thr Val 
            420                 425                 430         


Thr Lys Asp Val Thr Asp Lys Pro Leu Asp Leu Ser Ser Lys Val Val 
        435                 440                 445             


Asp Val Asp Ala Ser Lys Ala Asp His Met Lys Lys Met Ala Pro Thr 
    450                 455                 460                 


Val Leu Val His Ser Arg Ala Gly Ser Gly Leu Val Leu Ser Gly Ser 
465                 470                 475                 480 


Glu Ile Pro Lys Glu Thr Leu Ser Pro Pro Gly Asn Gly Cys Ala Ile 
                485                 490                 495     


Tyr Arg Ser Glu Ile Ile Ser Thr Ala Pro Ser Ser Trp Val Val Pro 
            500                 505                 510         


Gly Pro Ser Pro Asn Glu Glu Asn Asn Gly Lys Ser Met Ser Leu Lys 
        515                 520                 525             


Asn Lys Ala Leu Asp Trp Ala Ile Pro Gln Gln Arg Ser Ser Ser Cys 
    530                 535                 540                 


Pro Arg Met Gly Gly Thr Asp Ala Val Ile Thr Asn Val Ser Gly Ser 
545                 550                 555                 560 


Val Ser Ser Ala Gly Arg Pro Ala Ser Ala Ser Pro Ala Pro Asn Ala 
                565                 570                 575     


Asn Ala Asp Gly Thr Lys Thr Ser Arg Ser Ser Val Glu Thr Thr Pro 
            580                 585                 590         


Ser Val Ile Gln His Val Gly Gln Pro Pro Ala Thr Pro Ala Lys His 
        595                 600                 605             


Ser Ser Ser Thr Ser Ser Lys Gly Ala Lys Ala Ser Asn Pro Glu Pro 
    610                 615                 620                 


Ser Phe Lys Ala Asn Glu Asn Gly Leu Pro Pro Ser Ser Ile Phe Leu 
625                 630                 635                 640 


Ser Pro Asn Glu Ala Phe Arg Ser Pro Pro Ile Pro Tyr Pro Arg Ser 
                645                 650                 655     


Tyr Leu Pro Tyr Pro Ala Pro Glu Gly Ile Ala Val Ser Pro Leu Ser 
            660                 665                 670         


Leu His Gly Lys Gly Pro Val Tyr Pro His Pro Val Leu Leu Pro Asn 
        675                 680                 685             


Gly Ser Leu Phe Pro Gly His Leu Ala Pro Lys Pro Gly Leu Pro Tyr 
    690                 695                 700                 


Gly Leu Pro Thr Gly Arg Pro Glu Phe Val Thr Tyr Gln Asp Ala Leu 
705                 710                 715                 720 


Gly Leu Gly Met Val His Pro Met Leu Ile Pro His Thr Pro Ile Glu 
                725                 730                 735     


Ile Thr Lys Glu Glu Lys Pro Glu Arg Arg Ser Arg Ser His Glu Arg 
            740                 745                 750         


Ala Arg Tyr Glu Asp Pro Thr Leu Arg Asn Arg Phe Ser Glu Ile Leu 
        755                 760                 765             


Glu Thr Ser Ser Thr Lys Leu His Pro Asp Val Pro Thr Asp Lys Asn 
    770                 775                 780                 


Leu Lys Pro Asn Pro Asn Trp Asn Gln Gly Lys Thr Val Val Lys Ser 
785                 790                 795                 800 


Asp Lys Leu Val Tyr Val Asp Leu Leu Arg Glu Glu Pro Asp Ala Lys 
                805                 810                 815     


Thr Asp Thr Asn Val Ser Lys Pro Ser Phe Ala Ala Glu Ser Val Gly 
            820                 825                 830         


Gln Ser Ala Glu Pro Pro Lys Pro Ser Val Glu Pro Ala Leu Gln Gln 
        835                 840                 845             


His Arg Asp Phe Ile Ala Leu Arg Glu Glu Leu Gly Arg Ile Ser Asp 
    850                 855                 860                 


Phe His Glu Thr Tyr Thr Phe Lys Gln Pro Val Phe Thr Val Ser Lys 
865                 870                 875                 880 


Asp Ser Val Leu Ala Gly Thr Asn Lys Glu Asn Leu Gly Leu Pro Val 
                885                 890                 895     


Ser Thr Pro Phe Leu Glu Pro Pro Leu Gly Ser Asp Gly Pro Ala Val 
            900                 905                 910         


Thr Phe Gly Lys Thr Gln Glu Asp Pro Lys Pro Phe Cys Val Gly Ser 
        915                 920                 925             


Ala Pro Pro Ser Val Asp Val Thr Pro Thr Tyr Thr Lys Asp Gly Ala 
    930                 935                 940                 


Asp Glu Ala Glu Ser Asn Asp Gly Lys Val Leu Lys Pro Lys Pro Ser 
945                 950                 955                 960 


Lys Leu Ala Lys Arg Ile Ala Asn Ser Ala Gly Tyr Val Gly Asp Arg 
                965                 970                 975     


Phe Lys Cys Val Thr Thr Glu Leu Tyr Ala Asp Ser Ser Gln Leu Ser 
            980                 985                 990         


Arg Glu Gln Arg Ala Leu Gln Met  Glu Gly Leu Gln Glu  Asp Ser Ile 
        995                 1000                 1005             


Leu Cys  Leu Pro Ala Ala Tyr  Cys Glu Arg Ala Met  Met Arg Phe 
    1010                 1015                 1020             


Ser Glu  Leu Glu Met Lys Glu  Arg Glu Gly Gly His  Pro Ala Thr 
    1025                 1030                 1035             


Lys Asp  Ser Glu Met Cys Lys  Phe Ser Pro Ala Asp  Trp Glu Arg 
    1040                 1045                 1050             


Leu Lys  Gly Asn Gln Asp Lys  Lys Pro Lys Ser Val  Thr Leu Glu 
    1055                 1060                 1065             


Glu Ala  Ile Ala Glu Gln Asn  Glu Ser Glu Arg Cys  Glu Tyr Ser 
    1070                 1075                 1080             


Val Gly  Asn Lys His Arg Asp  Pro Phe Glu Ala Pro  Glu Asp Lys 
    1085                 1090                 1095             


Asp Leu  Pro Val Glu Lys Tyr  Phe Val Glu Arg Gln  Pro Val Ser 
    1100                 1105                 1110             


Glu Pro  Pro Ala Asp Gln Val  Ala Ser Asp Met Pro  His Ser Pro 
    1115                 1120                 1125             


Thr Leu  Arg Val Asp Arg Lys  Arg Lys Val Ser Gly  Asp Ser Ser 
    1130                 1135                 1140             


His Thr  Glu Thr Thr Ala Glu  Glu Val Pro Glu Asp  Pro Leu Leu 
    1145                 1150                 1155             


Lys Ala  Lys Arg Arg Arg Val  Ser Lys Gly Leu His  Pro Lys Lys 
    1160                 1165                 1170             


Gln Arg  His Leu Leu His Leu  Arg Glu Arg Trp Glu  Gln Gln Val 
    1175                 1180                 1185             


Ser Ala  Ala Asp Gly Lys Pro  Gly Arg Gln Ser Arg  Lys Glu Val 
    1190                 1195                 1200             


Thr Gln  Ala Thr Gln Pro Glu  Ala Ile Pro Gln Gly  Thr Asn Ile 
    1205                 1210                 1215             


Thr Glu  Glu Lys Pro Gly Arg  Lys Arg Ala Glu Ala  Lys Gly Asn 
    1220                 1225                 1230             


Arg Ser  Trp Ser Glu Glu Ser  Leu Lys Pro Ser Asp  Asn Glu Gln 
    1235                 1240                 1245             


Gly Leu  Pro Val Phe Ser Gly  Ser Pro Pro Met Lys  Ser Leu Ser 
    1250                 1255                 1260             


Ser Thr  Ser Ala Gly Gly Lys  Lys Gln Ala Gln Pro  Ser Cys Ala 
    1265                 1270                 1275             


Pro Ala  Ser Arg Pro Pro Ala  Lys Gln Gln Lys Ile  Lys Glu Asn 
    1280                 1285                 1290             


Gln Lys  Thr Asp Val Leu Cys  Ala Asp Glu Glu Glu  Asp Cys Gln 
    1295                 1300                 1305             


Ala Ala  Ser Leu Leu Gln Lys  Tyr Thr Asp Asn Ser  Glu Lys Pro 
    1310                 1315                 1320             


Ser Gly  Lys Arg Leu Cys Lys  Thr Lys His Leu Ile  Pro Gln Glu 
    1325                 1330                 1335             


Ser Arg  Arg Gly Leu Pro Leu  Thr Gly Glu Tyr Tyr  Val Glu Asn 
    1340                 1345                 1350             


Ala Asp  Gly Lys Val Thr Val  Arg Arg Phe Arg Lys  Arg Pro Glu 
    1355                 1360                 1365             


Pro Ser  Ser Asp Tyr Asp Leu  Ser Pro Ala Lys Gln  Glu Pro Lys 
    1370                 1375                 1380             


Pro Phe  Asp Arg Leu Gln Gln  Leu Leu Pro Ala Ser  Gln Ser Thr 
    1385                 1390                 1395             


Gln Leu  Pro Cys Ser Ser Ser  Pro Gln Glu Thr Thr  Gln Ser Arg 
    1400                 1405                 1410             


Pro Met  Pro Pro Glu Ala Arg  Arg Leu Ile Val Asn  Lys Asn Ala 
    1415                 1420                 1425             


Gly Glu  Thr Leu Leu Gln Arg  Ala Ala Arg Leu Gly  Tyr Glu Glu 
    1430                 1435                 1440             


Val Val  Leu Tyr Cys Leu Glu  Asn Lys Ile Cys Asp  Val Asn His 
    1445                 1450                 1455             


Arg Asp  Asn Ala Gly Tyr Cys  Ala Leu His Glu Ala  Cys Ala Arg 
    1460                 1465                 1470             


Gly Trp  Leu Asn Ile Val Arg  His Leu Leu Glu Tyr  Gly Ala Asp 
    1475                 1480                 1485             


Val Asn  Cys Ser Ala Gln Asp  Gly Thr Arg Pro Leu  His Asp Ala 
    1490                 1495                 1500             


Val Glu  Asn Asp His Leu Glu  Ile Val Arg Leu Leu  Leu Ser Tyr 
    1505                 1510                 1515             


Gly Ala  Asp Pro Thr Leu Ala  Thr Tyr Ser Gly Arg  Thr Ile Met 
    1520                 1525                 1530             


Lys Met  Thr His Ser Glu Leu  Met Glu Lys Phe Leu  Thr Asp Tyr 
    1535                 1540                 1545             


Leu Asn  Asp Leu Gln Gly Arg  Asn Asp Asp Asp Ala  Ser Gly Thr 
    1550                 1555                 1560             


Trp Asp  Phe Tyr Gly Ser Ser  Val Cys Glu Pro Asp  Asp Glu Ser 
    1565                 1570                 1575             


Gly Tyr  Asp Val Leu Ala Asn  Pro Pro Gly Pro Glu  Asp Gln Asp 
    1580                 1585                 1590             


Asp Asp  Asp Asp Ala Tyr Ser  Asp Val Phe Glu Phe  Glu Phe Ser 
    1595                 1600                 1605             


Glu Thr  Pro Leu Leu Pro Cys  Tyr Asn Ile Gln Val  Ser Val Ala 
    1610                 1615                 1620             


Gln Gly  Pro Arg Asn Trp Leu  Leu Leu Ser Asp Val  Leu Lys Lys 
    1625                 1630                 1635             


Leu Lys  Met Ser Ser Arg Ile  Phe Arg Cys Asn Phe  Pro Asn Val 
    1640                 1645                 1650             


Glu Ile  Val Thr Ile Ala Glu  Ala Glu Phe Tyr Arg  Gln Val Ser 
    1655                 1660                 1665             


Ala Ser  Leu Leu Phe Ser Cys  Ser Lys Asp Leu Glu  Ala Phe Asn 
    1670                 1675                 1680             


Pro Glu  Ser Lys Glu Leu Leu  Asp Leu Val Glu Phe  Thr Asn Glu 
    1685                 1690                 1695             


Ile Gln  Thr Leu Leu Gly Ser  Ser Val Glu Trp Leu  His Pro Ser 
    1700                 1705                 1710             


Asp Leu  Ala Ser Asp Asn Tyr  Trp 
    1715                 1720     


<210>  1119
<211>  1711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCORL1__Homo_sapiens__NP_068765

<400>  1119

Met Ile Ser Thr Ala Pro Leu Tyr Ser Gly Val His Asn Trp Thr Ser 
1               5                   10                  15      


Ser Asp Arg Ile Arg Met Cys Gly Ile Asn Glu Glu Arg Arg Ala Pro 
            20                  25                  30          


Leu Ser Asp Glu Glu Ser Thr Thr Gly Asp Cys Gln His Phe Gly Ser 
        35                  40                  45              


Gln Glu Phe Cys Val Ser Ser Ser Phe Ser Lys Val Glu Leu Thr Ala 
    50                  55                  60                  


Val Gly Ser Gly Ser Asn Ala Arg Gly Ala Asp Pro Asp Gly Ser Ala 
65                  70                  75                  80  


Thr Glu Lys Leu Gly His Lys Ser Glu Asp Lys Pro Asp Asp Pro Gln 
                85                  90                  95      


Pro Lys Met Asp Tyr Ala Gly Asn Val Ala Glu Ala Glu Gly Leu Leu 
            100                 105                 110         


Val Pro Leu Ser Ser Pro Gly Asp Gly Leu Lys Leu Pro Ala Ser Asp 
        115                 120                 125             


Ser Ala Glu Ala Ser Asn Ser Arg Ala Asp Cys Ser Trp Thr Pro Leu 
    130                 135                 140                 


Asn Thr Gln Met Ser Lys Gln Val Asp Cys Ser Pro Ala Gly Val Lys 
145                 150                 155                 160 


Ala Leu Asp Ser Arg Gln Gly Val Gly Glu Lys Asn Thr Phe Ile Leu 
                165                 170                 175     


Ala Thr Leu Gly Thr Gly Val Pro Val Glu Gly Thr Leu Pro Leu Val 
            180                 185                 190         


Thr Thr Asn Phe Ser Pro Leu Pro Ala Pro Ile Cys Pro Pro Ala Pro 
        195                 200                 205             


Gly Ser Ala Ser Val Pro His Ser Val Pro Asp Ala Phe Gln Val Pro 
    210                 215                 220                 


Leu Ser Val Pro Ala Pro Val Pro His Ser Gly Leu Val Pro Val Gln 
225                 230                 235                 240 


Val Ala Thr Ser Val Pro Ala Pro Ser Pro Pro Leu Ala Pro Val Pro 
                245                 250                 255     


Ala Leu Ala Pro Ala Pro Pro Ser Val Pro Thr Leu Ile Ser Asp Ser 
            260                 265                 270         


Asn Pro Leu Ser Val Ser Ala Ser Val Leu Val Pro Val Pro Ala Ser 
        275                 280                 285             


Ala Pro Pro Ser Gly Pro Val Pro Leu Ser Ala Pro Ala Pro Ala Pro 
    290                 295                 300                 


Leu Ser Val Pro Val Ser Ala Pro Pro Leu Ala Leu Ile Gln Ala Pro 
305                 310                 315                 320 


Val Pro Pro Ser Ala Pro Thr Leu Val Leu Ala Pro Val Pro Thr Pro 
                325                 330                 335     


Val Leu Ala Pro Met Pro Ala Ser Thr Pro Pro Ala Ala Pro Ala Pro 
            340                 345                 350         


Pro Ser Val Pro Met Pro Thr Pro Thr Pro Ser Ser Gly Pro Pro Ser 
        355                 360                 365             


Thr Pro Thr Leu Ile Pro Ala Phe Ala Pro Thr Pro Val Pro Ala Pro 
    370                 375                 380                 


Thr Pro Ala Pro Ile Phe Thr Pro Ala Pro Thr Pro Met Pro Ala Ala 
385                 390                 395                 400 


Thr Pro Ala Ala Ile Pro Thr Ser Ala Pro Ile Pro Ala Ser Phe Ser 
                405                 410                 415     


Leu Ser Arg Val Cys Phe Pro Ala Ala Gln Ala Pro Ala Met Gln Lys 
            420                 425                 430         


Val Pro Leu Ser Phe Gln Pro Gly Thr Val Leu Thr Pro Ser Gln Pro 
        435                 440                 445             


Leu Val Tyr Ile Pro Pro Pro Ser Cys Gly Gln Pro Leu Ser Val Ala 
    450                 455                 460                 


Thr Leu Pro Thr Thr Leu Gly Val Ser Ser Thr Leu Thr Leu Pro Val 
465                 470                 475                 480 


Leu Pro Ser Tyr Leu Gln Asp Arg Cys Leu Pro Gly Val Leu Ala Ser 
                485                 490                 495     


Pro Glu Leu Arg Ser Tyr Pro Tyr Ala Phe Ser Val Ala Arg Pro Leu 
            500                 505                 510         


Thr Ser Asp Ser Lys Leu Val Ser Leu Glu Val Asn Arg Leu Pro Cys 
        515                 520                 525             


Thr Ser Pro Ser Gly Ser Thr Thr Thr Gln Pro Ala Pro Asp Gly Val 
    530                 535                 540                 


Pro Gly Pro Leu Ala Asp Thr Ser Leu Val Thr Ala Ser Ala Lys Val 
545                 550                 555                 560 


Leu Pro Thr Pro Gln Pro Leu Leu Pro Ala Pro Ser Gly Ser Ser Ala 
                565                 570                 575     


Pro Pro His Pro Ala Lys Met Pro Ser Gly Thr Glu Gln Gln Thr Glu 
            580                 585                 590         


Gly Thr Ser Val Thr Phe Ser Pro Leu Lys Ser Pro Pro Gln Leu Glu 
        595                 600                 605             


Arg Glu Met Ala Ser Pro Pro Glu Cys Ser Glu Met Pro Leu Asp Leu 
    610                 615                 620                 


Ser Ser Lys Ser Asn Arg Gln Lys Leu Pro Leu Pro Asn Gln Arg Lys 
625                 630                 635                 640 


Thr Pro Pro Met Pro Val Leu Thr Pro Val His Thr Ser Ser Lys Ala 
                645                 650                 655     


Leu Leu Ser Thr Val Leu Ser Arg Ser Gln Arg Thr Thr Gln Ala Ala 
            660                 665                 670         


Gly Gly Asn Val Thr Ser Cys Leu Gly Ser Thr Ser Ser Pro Phe Val 
        675                 680                 685             


Ile Phe Pro Glu Ile Val Arg Asn Gly Asp Pro Ser Thr Trp Val Lys 
    690                 695                 700                 


Asn Ser Thr Ala Leu Ile Ser Thr Ile Pro Gly Thr Tyr Val Gly Val 
705                 710                 715                 720 


Ala Asn Pro Val Pro Ala Ser Leu Leu Leu Asn Lys Asp Pro Asn Leu 
                725                 730                 735     


Gly Leu Asn Arg Asp Pro Arg His Leu Pro Lys Gln Glu Pro Ile Ser 
            740                 745                 750         


Ile Ile Asp Gln Gly Glu Pro Lys Gly Thr Gly Ala Thr Cys Gly Lys 
        755                 760                 765             


Lys Gly Ser Gln Ala Gly Ala Glu Gly Gln Pro Ser Thr Val Lys Arg 
    770                 775                 780                 


Tyr Thr Pro Ala Arg Ile Ala Pro Gly Leu Pro Gly Cys Gln Thr Lys 
785                 790                 795                 800 


Glu Leu Ser Leu Trp Lys Pro Thr Gly Pro Ala Asn Ile Tyr Pro Arg 
                805                 810                 815     


Cys Ser Val Asn Gly Lys Pro Thr Ser Thr Gln Val Leu Pro Val Gly 
            820                 825                 830         


Trp Ser Pro Tyr His Gln Ala Ser Leu Leu Ser Ile Gly Ile Ser Ser 
        835                 840                 845             


Ala Gly Gln Leu Thr Pro Ser Gln Gly Ala Pro Ile Arg Pro Thr Ser 
    850                 855                 860                 


Val Val Ser Glu Phe Ser Gly Val Pro Ser Leu Ser Ser Ser Glu Ala 
865                 870                 875                 880 


Val His Gly Leu Pro Glu Gly Gln Pro Arg Pro Gly Gly Ser Phe Val 
                885                 890                 895     


Pro Glu Gln Asp Pro Val Thr Lys Asn Lys Thr Cys Arg Ile Ala Ala 
            900                 905                 910         


Lys Pro Tyr Glu Glu Gln Val Asn Pro Val Leu Leu Thr Leu Ser Pro 
        915                 920                 925             


Gln Thr Gly Thr Leu Ala Leu Ser Val Gln Pro Ser Gly Gly Asp Ile 
    930                 935                 940                 


Arg Met Asn Gln Gly Pro Glu Glu Ser Glu Ser His Leu Cys Ser Asp 
945                 950                 955                 960 


Ser Thr Pro Lys Met Glu Gly Pro Gln Gly Ala Cys Gly Leu Lys Leu 
                965                 970                 975     


Ala Gly Asp Thr Lys Pro Lys Asn Gln Val Leu Ala Thr Tyr Met Ser 
            980                 985                 990         


His Glu Leu Val Leu Ala Thr Pro  Gln Asn Leu Pro Lys  Met Pro Glu 
        995                 1000                 1005             


Leu Pro  Leu Leu Pro His Asp  Ser His Pro Lys Glu  Leu Ile Leu 
    1010                 1015                 1020             


Asp Val  Val Pro Ser Ser Arg  Arg Gly Ser Ser Thr  Glu Arg Pro 
    1025                 1030                 1035             


Gln Leu  Gly Ser Gln Val Asp  Leu Gly Arg Val Lys  Met Glu Lys 
    1040                 1045                 1050             


Val Asp  Gly Asp Val Val Phe  Asn Leu Ala Thr Cys  Phe Arg Ala 
    1055                 1060                 1065             


Asp Gly  Leu Pro Val Ala Pro  Gln Arg Gly Gln Ala  Glu Val Arg 
    1070                 1075                 1080             


Ala Lys  Ala Gly Gln Ala Arg  Val Lys Gln Glu Ser  Val Gly Val 
    1085                 1090                 1095             


Phe Ala  Cys Lys Asn Lys Trp  Gln Pro Asp Asp Val  Thr Glu Ser 
    1100                 1105                 1110             


Leu Pro  Pro Lys Lys Met Lys  Cys Gly Lys Glu Lys  Asp Ser Glu 
    1115                 1120                 1125             


Glu Gln  Gln Leu Gln Pro Gln  Ala Lys Ala Val Val  Arg Ser Ser 
    1130                 1135                 1140             


His Arg  Pro Lys Cys Arg Lys  Leu Pro Ser Asp Pro  Gln Glu Ser 
    1145                 1150                 1155             


Thr Lys  Lys Ser Pro Arg Gly  Ala Ser Asp Ser Gly  Lys Glu His 
    1160                 1165                 1170             


Asn Gly  Val Arg Gly Lys His  Lys His Arg Lys Pro  Thr Lys Pro 
    1175                 1180                 1185             


Glu Ser  Gln Ser Pro Gly Lys  Arg Ala Asp Ser His  Glu Glu Gly 
    1190                 1195                 1200             


Ser Leu  Glu Lys Lys Ala Lys  Ser Ser Phe Arg Asp  Phe Ile Pro 
    1205                 1210                 1215             


Val Val  Leu Ser Thr Arg Thr  Arg Ser Gln Ser Gly  Ser Ile Cys 
    1220                 1225                 1230             


Ser Ser  Phe Ala Gly Met Ala  Asp Ser Asp Met Gly  Ser Gln Glu 
    1235                 1240                 1245             


Val Phe  Pro Thr Glu Glu Glu  Glu Glu Val Thr Pro  Thr Pro Ala 
    1250                 1255                 1260             


Lys Arg  Arg Lys Val Arg Lys  Thr Gln Arg Asp Thr  Gln Tyr Arg 
    1265                 1270                 1275             


Ser His  His Ala Gln Asp Lys  Ser Leu Leu Ser Gln  Gly Arg Arg 
    1280                 1285                 1290             


His Leu  Trp Arg Ala Arg Glu  Met Pro Trp Arg Thr  Glu Ala Ala 
    1295                 1300                 1305             


Arg Gln  Met Trp Asp Thr Asn  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1310                 1315                 1320             


Glu Gly  Leu Leu Lys Arg Lys  Lys Arg Arg Arg Gln  Lys Ser Arg 
    1325                 1330                 1335             


Lys Tyr  Gln Thr Gly Glu Tyr  Leu Thr Glu Gln Glu  Asp Glu Gln 
    1340                 1345                 1350             


Arg Arg  Lys Gly Arg Ala Asp  Leu Lys Ala Arg Lys  Gln Lys Thr 
    1355                 1360                 1365             


Ser Ser  Ser Gln Ser Leu Glu  His Arg Leu Arg Asn  Arg Asn Leu 
    1370                 1375                 1380             


Leu Leu  Pro Asn Lys Val Gln  Gly Ile Ser Asp Ser  Pro Asn Gly 
    1385                 1390                 1395             


Phe Leu  Pro Asn Asn Leu Glu  Glu Pro Ala Cys Leu  Glu Asn Ser 
    1400                 1405                 1410             


Glu Lys  Pro Ser Gly Lys Arg  Lys Cys Lys Thr Lys  His Met Ala 
    1415                 1420                 1425             


Thr Val  Ser Glu Glu Ala Lys  Asp Val Val Leu Tyr  Cys Leu Gln 
    1430                 1435                 1440             


Lys Asp  Ser Glu Asp Val Asn  His Arg Asp Asn Ala  Gly Tyr Thr 
    1445                 1450                 1455             


Ala Leu  His Glu Ala Cys Ser  Arg Gly Trp Thr Asp  Ile Leu Asn 
    1460                 1465                 1470             


Ile Leu  Leu Glu His Gly Ala  Asn Val Asn Cys Ser  Ala Gln Asp 
    1475                 1480                 1485             


Gly Thr  Arg Pro Val His Asp  Ala Val Val Asn Asp  Asn Leu Glu 
    1490                 1495                 1500             


Thr Ile  Trp Leu Leu Leu Ser  Tyr Gly Ala Asp Pro  Thr Leu Ala 
    1505                 1510                 1515             


Thr Tyr  Ser Gly Gln Thr Ala  Met Lys Leu Ala Ser  Ser Asp Thr 
    1520                 1525                 1530             


Met Lys  Arg Phe Leu Ser Asp  His Leu Ser Asp Leu  Gln Gly Arg 
    1535                 1540                 1545             


Ala Glu  Gly Asp Pro Gly Val  Ser Trp Asp Phe Tyr  Ser Ser Ser 
    1550                 1555                 1560             


Val Leu  Glu Glu Lys Asp Gly  Phe Ala Cys Asp Leu  Leu His Asn 
    1565                 1570                 1575             


Pro Pro  Gly Ser Ser Asp Gln  Glu Gly Asp Asp Pro  Met Glu Glu 
    1580                 1585                 1590             


Asp Asp  Phe Met Phe Glu Leu  Ser Asp Lys Pro Leu  Leu Pro Cys 
    1595                 1600                 1605             


Tyr Asn  Leu Gln Val Ser Val  Ser Arg Gly Pro Cys  Asn Trp Phe 
    1610                 1615                 1620             


Leu Phe  Ser Asp Val Leu Lys  Arg Leu Lys Leu Ser  Ser Arg Ile 
    1625                 1630                 1635             


Phe Gln  Ala Arg Phe Pro His  Phe Glu Ile Thr Thr  Met Pro Lys 
    1640                 1645                 1650             


Ala Glu  Phe Tyr Arg Gln Val  Ala Ser Ser Gln Leu  Leu Thr Pro 
    1655                 1660                 1665             


Ala Glu  Arg Pro Gly Gly Leu  Asp Asp Arg Ser Pro  Pro Gly Ser 
    1670                 1675                 1680             


Ser Glu  Thr Val Glu Leu Val  Arg Tyr Glu Pro Asp  Leu Leu Arg 
    1685                 1690                 1695             


Leu Leu  Gly Ser Glu Val Glu  Phe Gln Ser Cys Asn  Ser 
    1700                 1705                 1710     


<210>  1120
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCR__Homo_sapiens__NP_004318

<400>  1120

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Asn Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Asp Asp Glu Ser Pro Gly Leu Tyr Gly Phe 
            900                 905                 910         


Leu Asn Val Ile Val His Ser Ala Thr Gly Phe Lys Gln Ser Ser Asn 
        915                 920                 925             


Leu Tyr Cys Thr Leu Glu Val Asp Ser Phe Gly Tyr Phe Val Asn Lys 
    930                 935                 940                 


Ala Lys Thr Arg Val Tyr Arg Asp Thr Ala Glu Pro Asn Trp Asn Glu 
945                 950                 955                 960 


Glu Phe Glu Ile Glu Leu Glu Gly Ser Gln Thr Leu Arg Ile Leu Cys 
                965                 970                 975     


Tyr Glu Lys Cys Tyr Asn Lys Thr Lys Ile Pro Lys Glu Asp Gly Glu 
            980                 985                 990         


Ser Thr Asp Arg Leu Met Gly Lys  Gly Gln Val Gln Leu  Asp Pro Gln 
        995                 1000                 1005             


Ala Leu  Gln Asp Arg Asp Trp  Gln Arg Thr Val Ile  Ala Met Asn 
    1010                 1015                 1020             


Gly Ile  Glu Val Lys Leu Ser  Val Lys Phe Asn Ser  Arg Glu Phe 
    1025                 1030                 1035             


Ser Leu  Lys Arg Met Pro Ser  Arg Lys Gln Thr Gly  Val Phe Gly 
    1040                 1045                 1050             


Val Lys  Ile Ala Val Val Thr  Lys Arg Glu Arg Ser  Lys Val Pro 
    1055                 1060                 1065             


Tyr Ile  Val Arg Gln Cys Val  Glu Glu Ile Glu Arg  Arg Gly Met 
    1070                 1075                 1080             


Glu Glu  Val Gly Ile Tyr Arg  Val Ser Gly Val Ala  Thr Asp Ile 
    1085                 1090                 1095             


Gln Ala  Leu Lys Ala Ala Phe  Asp Val Asn Asn Lys  Asp Val Ser 
    1100                 1105                 1110             


Val Met  Met Ser Glu Met Asp  Val Asn Ala Ile Ala  Gly Thr Leu 
    1115                 1120                 1125             


Lys Leu  Tyr Phe Arg Glu Leu  Pro Glu Pro Leu Phe  Thr Asp Glu 
    1130                 1135                 1140             


Phe Tyr  Pro Asn Phe Ala Glu  Gly Ile Ala Leu Ser  Asp Pro Val 
    1145                 1150                 1155             


Ala Lys  Glu Ser Cys Met Leu  Asn Leu Leu Leu Ser  Leu Pro Glu 
    1160                 1165                 1170             


Ala Asn  Leu Leu Thr Phe Leu  Phe Leu Leu Asp His  Leu Lys Arg 
    1175                 1180                 1185             


Val Ala  Glu Lys Glu Ala Val  Asn Lys Met Ser Leu  His Asn Leu 
    1190                 1195                 1200             


Ala Thr  Val Phe Gly Pro Thr  Leu Leu Arg Pro Ser  Glu Lys Glu 
    1205                 1210                 1215             


Ser Lys  Leu Pro Ala Asn Pro  Ser Gln Pro Ile Thr  Met Thr Asp 
    1220                 1225                 1230             


Ser Trp  Ser Leu Glu Val Met  Ser Gln Val Gln Val  Leu Leu Tyr 
    1235                 1240                 1245             


Phe Leu  Gln Leu Glu Ala Ile  Pro Ala Pro Asp Ser  Lys Arg Gln 
    1250                 1255                 1260             


Ser Ile  Leu Phe Ser Thr Glu  Val 
    1265                 1270     


<210>  1121
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCS1L__Homo_sapiens__NP_001073335

<400>  1121

Met Pro Leu Ser Asp Phe Ile Leu Ala Leu Lys Asp Asn Pro Tyr Phe 
1               5                   10                  15      


Gly Ala Gly Phe Gly Leu Val Gly Val Gly Thr Ala Leu Ala Leu Ala 
            20                  25                  30          


Arg Lys Gly Val Gln Leu Gly Leu Val Ala Phe Arg Arg His Tyr Met 
        35                  40                  45              


Ile Thr Leu Glu Val Pro Ala Arg Asp Arg Ser Tyr Ala Trp Leu Leu 
    50                  55                  60                  


Ser Trp Leu Thr Arg His Ser Thr Arg Thr Gln His Leu Ser Val Glu 
65                  70                  75                  80  


Thr Ser Tyr Leu Gln His Glu Ser Gly Arg Ile Ser Thr Lys Phe Glu 
                85                  90                  95      


Phe Val Pro Ser Pro Gly Asn His Phe Ile Trp Tyr Arg Gly Lys Trp 
            100                 105                 110         


Ile Arg Val Glu Arg Ser Arg Glu Met Gln Met Ile Asp Leu Gln Thr 
        115                 120                 125             


Gly Thr Pro Trp Glu Ser Val Thr Phe Thr Ala Leu Gly Thr Asp Arg 
    130                 135                 140                 


Lys Val Phe Phe Asn Ile Leu Glu Glu Ala Arg Glu Leu Ala Leu Gln 
145                 150                 155                 160 


Gln Glu Glu Gly Lys Thr Val Met Tyr Thr Ala Val Gly Ser Glu Trp 
                165                 170                 175     


Arg Pro Phe Gly Tyr Pro Arg Arg Arg Arg Pro Leu Asn Ser Val Val 
            180                 185                 190         


Leu Gln Gln Gly Leu Ala Asp Arg Ile Val Arg Asp Val Gln Glu Phe 
        195                 200                 205             


Ile Asp Asn Pro Lys Trp Tyr Thr Asp Arg Gly Ile Pro Tyr Arg Arg 
    210                 215                 220                 


Gly Tyr Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Ser Ser Phe Ile 
225                 230                 235                 240 


Thr Ala Leu Ala Gly Glu Leu Glu His Ser Ile Cys Leu Leu Ser Leu 
                245                 250                 255     


Thr Asp Ser Ser Leu Ser Asp Asp Arg Leu Asn His Leu Leu Ser Val 
            260                 265                 270         


Ala Pro Gln Gln Ser Leu Val Leu Leu Glu Asp Val Asp Ala Ala Phe 
        275                 280                 285             


Leu Ser Arg Asp Leu Ala Val Glu Asn Pro Val Lys Tyr Gln Gly Leu 
    290                 295                 300                 


Gly Arg Leu Thr Phe Ser Gly Leu Leu Asn Ala Leu Asp Gly Val Ala 
305                 310                 315                 320 


Ser Thr Glu Ala Arg Ile Val Phe Met Thr Thr Asn His Val Asp Arg 
                325                 330                 335     


Leu Asp Pro Ala Leu Ile Arg Pro Gly Arg Val Asp Leu Lys Glu Tyr 
            340                 345                 350         


Val Gly Tyr Cys Ser His Trp Gln Leu Thr Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Tyr Pro Gly Gln Ala Pro Ser Leu Ala Glu Asn Phe Ala Glu His Val 
    370                 375                 380                 


Leu Arg Ala Thr Asn Gln Ile Ser Pro Ala Gln Val Gln Gly Tyr Phe 
385                 390                 395                 400 


Met Leu Tyr Lys Asn Asp Pro Val Gly Ala Ile His Asn Ala Glu Ser 
                405                 410                 415     


Leu Arg Arg 
            


<210>  1122
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDH1__Homo_sapiens__NP_976059

<400>  1122

Met Leu Ala Thr Arg Leu Ser Arg Pro Leu Ser Arg Leu Pro Gly Lys 
1               5                   10                  15      


Thr Leu Ser Ala Cys Asp Arg Glu Asn Gly Ala Arg Arg Pro Leu Leu 
            20                  25                  30          


Leu Gly Ser Thr Ser Phe Ile Pro Ile Gly Arg Arg Thr Tyr Ala Ser 
        35                  40                  45              


Ala Ala Glu Pro Val Gly Ser Lys Ala Val Leu Val Thr Gly Cys Asp 
    50                  55                  60                  


Ser Gly Phe Gly Phe Ser Leu Ala Lys His Leu His Ser Lys Gly Phe 
65                  70                  75                  80  


Leu Val Phe Ala Gly Cys Leu Met Lys Asp Lys Gly His Asp Gly Val 
                85                  90                  95      


Lys Glu Leu Asp Ser Leu Asn Ser Asp Arg Leu Arg Thr Val Gln Leu 
            100                 105                 110         


Asn Val Cys Ser Ser Glu Glu Val Glu Lys Val Val Glu Ile Val Arg 
        115                 120                 125             


Ser Ser Leu Lys Asp Pro Glu Lys Gly Met Trp Gly Leu Val Asn Asn 
    130                 135                 140                 


Ala Gly Ile Ser Thr Phe Gly Glu Val Glu Phe Thr Ser Leu Glu Thr 
145                 150                 155                 160 


Tyr Lys Gln Val Ala Glu Val Asn Leu Trp Gly Thr Val Arg Met Thr 
                165                 170                 175     


Lys Ser Phe Leu Pro Leu Ile Arg Arg Ala Lys Gly Arg Val Val Asn 
            180                 185                 190         


Ile Ser Ser Met Leu Gly Arg Met Ala Asn Pro Ala Arg Ser Pro Tyr 
        195                 200                 205             


Cys Ile Thr Lys Phe Gly Val Glu Ala Phe Ser Asp Cys Leu Arg Tyr 
    210                 215                 220                 


Glu Met Tyr Pro Leu Gly Val Lys Val Ser Val Val Glu Pro Gly Asn 
225                 230                 235                 240 


Phe Ile Ala Ala Thr Ser Leu Tyr Ser Pro Glu Ser Ile Gln Ala Ile 
                245                 250                 255     


Ala Lys Lys Met Trp Glu Glu Leu Pro Glu Val Val Arg Lys Asp Tyr 
            260                 265                 270         


Gly Lys Lys Tyr Phe Asp Glu Lys Ile Ala Lys Met Glu Thr Tyr Cys 
        275                 280                 285             


Ser Ser Gly Ser Thr Asp Thr Ser Pro Val Ile Asp Ala Val Thr His 
    290                 295                 300                 


Ala Leu Thr Ala Thr Thr Pro Tyr Thr Arg Tyr His Pro Met Asp Tyr 
305                 310                 315                 320 


Tyr Trp Trp Leu Arg Met Gln Ile Met Thr His Leu Pro Gly Ala Ile 
                325                 330                 335     


Ser Asp Met Ile Tyr Ile Arg 
            340             


<210>  1123
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDH2__Homo_sapiens__XP_005263197

<400>  1123

Met Gly Arg Leu Asp Gly Lys Val Ile Ile Leu Thr Ala Ala Ala Gln 
1               5                   10                  15      


Gly Ile Gly Gln Ala Ala Ala Leu Ala Phe Ala Arg Glu Gly Ala Lys 
            20                  25                  30          


Val Ile Ala Thr Asp Ile Asn Glu Ser Lys Leu Gln Glu Leu Glu Lys 
        35                  40                  45              


Tyr Pro Gly Ile Gln Thr Arg Val Leu Asp Val Thr Lys Lys Lys Gln 
    50                  55                  60                  


Ile Asp Gln Phe Ala Asn Glu Val Glu Arg Leu Asp Val Leu Phe Asn 
65                  70                  75                  80  


Val Ala Gly Phe Val His His Gly Thr Val Leu Asp Cys Glu Glu Lys 
                85                  90                  95      


Asp Trp Asp Phe Ser Met Asn Leu Asn Val Arg Ser Met Tyr Leu Met 
            100                 105                 110         


Ile Lys Ala Phe Leu Pro Lys Met Leu Ala Gln Lys Ser Gly Asn Ile 
        115                 120                 125             


Ile Asn Met Ser Ser Val Ala Ser Ser Val Lys Gly Thr Val Asp Thr 
    130                 135                 140                 


Pro Ser Leu Gln Glu Arg Ile Gln Ala Arg Gly Asn Pro Glu Glu Ala 
145                 150                 155                 160 


Arg Asn Asp Phe Leu Lys Arg Gln Lys Thr Gly Arg Phe Ala Thr Ala 
                165                 170                 175     


Glu Glu Ile Ala Met Leu Cys Val Tyr Leu Ala Ser Asp Glu Ser Ala 
            180                 185                 190         


Tyr Val Thr Gly Asn Pro Val Ile Ile Asp Gly Gly Trp Ser Leu 
        195                 200                 205         


<210>  1124
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDKRB1__Homo_sapiens__NP_000701

<400>  1124

Met Ala Ser Ser Trp Pro Pro Leu Glu Leu Gln Ser Ser Asn Gln Ser 
1               5                   10                  15      


Gln Leu Phe Pro Gln Asn Ala Thr Ala Cys Asp Asn Ala Pro Glu Ala 
            20                  25                  30          


Trp Asp Leu Leu His Arg Val Leu Pro Thr Phe Ile Ile Ser Ile Cys 
        35                  40                  45              


Phe Phe Gly Leu Leu Gly Asn Leu Phe Val Leu Leu Val Phe Leu Leu 
    50                  55                  60                  


Pro Arg Arg Gln Leu Asn Val Ala Glu Ile Tyr Leu Ala Asn Leu Ala 
65                  70                  75                  80  


Ala Ser Asp Leu Val Phe Val Leu Gly Leu Pro Phe Trp Ala Glu Asn 
                85                  90                  95      


Ile Trp Asn Gln Phe Asn Trp Pro Phe Gly Ala Leu Leu Cys Arg Val 
            100                 105                 110         


Ile Asn Gly Val Ile Lys Ala Asn Leu Phe Ile Ser Ile Phe Leu Val 
        115                 120                 125             


Val Ala Ile Ser Gln Asp Arg Tyr Arg Val Leu Val His Pro Met Ala 
    130                 135                 140                 


Ser Arg Arg Gln Gln Arg Arg Arg Gln Ala Arg Val Thr Cys Val Leu 
145                 150                 155                 160 


Ile Trp Val Val Gly Gly Leu Leu Ser Ile Pro Thr Phe Leu Leu Arg 
                165                 170                 175     


Ser Ile Gln Ala Val Pro Asp Leu Asn Ile Thr Ala Cys Ile Leu Leu 
            180                 185                 190         


Leu Pro His Glu Ala Trp His Phe Ala Arg Ile Val Glu Leu Asn Ile 
        195                 200                 205             


Leu Gly Phe Leu Leu Pro Leu Ala Ala Ile Val Phe Phe Asn Tyr His 
    210                 215                 220                 


Ile Leu Ala Ser Leu Arg Thr Arg Glu Glu Val Ser Arg Thr Arg Cys 
225                 230                 235                 240 


Gly Gly Arg Lys Asp Ser Lys Thr Thr Ala Leu Ile Leu Thr Leu Val 
                245                 250                 255     


Val Ala Phe Leu Val Cys Trp Ala Pro Tyr His Phe Phe Ala Phe Leu 
            260                 265                 270         


Glu Phe Leu Phe Gln Val Gln Ala Val Arg Gly Cys Phe Trp Glu Asp 
        275                 280                 285             


Phe Ile Asp Leu Gly Leu Gln Leu Ala Asn Phe Phe Ala Phe Thr Asn 
    290                 295                 300                 


Ser Ser Leu Asn Pro Val Ile Tyr Val Phe Val Gly Arg Leu Phe Arg 
305                 310                 315                 320 


Thr Lys Val Trp Glu Leu Tyr Lys Gln Cys Thr Pro Lys Ser Leu Ala 
                325                 330                 335     


Pro Ile Ser Ser Ser His Arg Lys Glu Ile Phe Gln Leu Phe Trp Arg 
            340                 345                 350         


Asn 
    


<210>  1125
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDKRB2__Homo_sapiens__NP_000614

<400>  1125

Met Phe Ser Pro Trp Lys Ile Ser Met Phe Leu Ser Val Arg Glu Asp 
1               5                   10                  15      


Ser Val Pro Thr Thr Ala Ser Phe Ser Ala Asp Met Leu Asn Val Thr 
            20                  25                  30          


Leu Gln Gly Pro Thr Leu Asn Gly Thr Phe Ala Gln Ser Lys Cys Pro 
        35                  40                  45              


Gln Val Glu Trp Leu Gly Trp Leu Asn Thr Ile Gln Pro Pro Phe Leu 
    50                  55                  60                  


Trp Val Leu Phe Val Leu Ala Thr Leu Glu Asn Ile Phe Val Leu Ser 
65                  70                  75                  80  


Val Phe Cys Leu His Lys Ser Ser Cys Thr Val Ala Glu Ile Tyr Leu 
                85                  90                  95      


Gly Asn Leu Ala Ala Ala Asp Leu Ile Leu Ala Cys Gly Leu Pro Phe 
            100                 105                 110         


Trp Ala Ile Thr Ile Ser Asn Asn Phe Asp Trp Leu Phe Gly Glu Thr 
        115                 120                 125             


Leu Cys Arg Val Val Asn Ala Ile Ile Ser Met Asn Leu Tyr Ser Ser 
    130                 135                 140                 


Ile Cys Phe Leu Met Leu Val Ser Ile Asp Arg Tyr Leu Ala Leu Val 
145                 150                 155                 160 


Lys Thr Met Ser Met Gly Arg Met Arg Gly Val Arg Trp Ala Lys Leu 
                165                 170                 175     


Tyr Ser Leu Val Ile Trp Gly Cys Thr Leu Leu Leu Ser Ser Pro Met 
            180                 185                 190         


Leu Val Phe Arg Thr Met Lys Glu Tyr Ser Asp Glu Gly His Asn Val 
        195                 200                 205             


Thr Ala Cys Val Ile Ser Tyr Pro Ser Leu Ile Trp Glu Val Phe Thr 
    210                 215                 220                 


Asn Met Leu Leu Asn Val Val Gly Phe Leu Leu Pro Leu Ser Val Ile 
225                 230                 235                 240 


Thr Phe Cys Thr Met Gln Ile Met Gln Val Leu Arg Asn Asn Glu Met 
                245                 250                 255     


Gln Lys Phe Lys Glu Ile Gln Thr Glu Arg Arg Ala Thr Val Leu Val 
            260                 265                 270         


Leu Val Val Leu Leu Leu Phe Ile Ile Cys Trp Leu Pro Phe Gln Ile 
        275                 280                 285             


Ser Thr Phe Leu Asp Thr Leu His Arg Leu Gly Ile Leu Ser Ser Cys 
    290                 295                 300                 


Gln Asp Glu Arg Ile Ile Asp Val Ile Thr Gln Ile Ala Ser Phe Met 
305                 310                 315                 320 


Ala Tyr Ser Asn Ser Cys Leu Asn Pro Leu Val Tyr Val Ile Val Gly 
                325                 330                 335     


Lys Arg Phe Arg Lys Lys Ser Trp Glu Val Tyr Gln Gly Val Cys Gln 
            340                 345                 350         


Lys Gly Gly Cys Arg Ser Glu Pro Ile Gln Met Glu Asn Ser Met Gly 
        355                 360                 365             


Thr Leu Arg Thr Ser Ile Ser Val Glu Arg Gln Ile His Lys Leu Gln 
    370                 375                 380                 


Asp Trp Ala Gly Ser Arg Gln 
385                 390     


<210>  1126
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDNF__Homo_sapiens__NP_001137280

<400>  1126

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  1127
<211>  2624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDP1__Homo_sapiens__NP_060899

<400>  1127

Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Thr Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Asp Pro Ala Thr Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Thr Asp Val Pro Thr Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Thr Glu Lys Thr Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Thr Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Thr Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Thr Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Thr Ala Thr Ser Thr Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Thr Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Thr Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Thr Glu Lys Pro Ser Thr Pro Val Gln Thr Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Thr Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Thr Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Thr Val Glu Val Leu Arg Thr Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Thr 
        275                 280                 285             


Thr Thr Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Thr Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Thr 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Thr Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Thr Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Thr Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Thr Val Glu Glu Glu Ser Leu Thr Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Thr Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Thr Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Thr Glu Lys Val Glu Lys Arg Thr Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Thr Ser Val Ala Thr Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Thr Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Thr Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Thr Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Thr Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Thr Leu Asp Ile Leu Arg Met Glu Thr Thr Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Thr Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Thr Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Arg Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Thr Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Thr Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala Ala Leu Arg 
        835                 840                 845             


Glu Thr Val Arg Leu Asp Thr Ser Pro Lys Glu Met Val Pro Ala Glu 
    850                 855                 860                 


Ile Asn Thr Lys Glu Met Gln Ser Asp Leu Lys Glu Thr Gly Arg Arg 
865                 870                 875                 880 


Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp Asp Thr Ile 
                885                 890                 895     


Glu Met Glu Thr Gly Leu Lys Ala Met Gly Arg Glu Ile Cys Leu Arg 
            900                 905                 910         


Glu Lys Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile Asp Lys Asp 
        915                 920                 925             


Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys Asn Gly Pro 
    930                 935                 940                 


Glu Glu Val Lys Pro Leu Gly Glu Val Glu Thr Asp Leu Lys Ala Thr 
945                 950                 955                 960 


Gly Asn Glu Ser Ser Pro Arg Glu Lys Thr Pro Glu Val Thr Asp Ala 
                965                 970                 975     


Thr Glu Glu Ile Asp Lys Asn Leu Glu Glu Thr Gly Arg Arg Lys Ile 
            980                 985                 990         


Ser Pro Arg Glu Asn Gly Pro Glu  Glu Val Lys Pro Val  Asp Glu Met 
        995                 1000                 1005             


Glu Thr  Asp Leu Asn Ala Thr  Gly Arg Glu Ser Ser  Pro Arg Glu 
    1010                 1015                 1020             


Lys Thr  Pro Glu Val Ile Asp  Ala Thr Glu Glu Ile  Asp Leu Glu 
    1025                 1030                 1035             


Glu Thr  Glu Arg Glu Val Ser  Pro Gln Glu Asn Gly  Leu Glu Glu 
    1040                 1045                 1050             


Val Lys  Pro Leu Gly Glu Met  Glu Thr Asp Leu Lys  Ala Thr Gly 
    1055                 1060                 1065             


Arg Asp  Ser Phe Pro Arg Gly  Lys Thr Pro Glu Val  Ile Asp Ala 
    1070                 1075                 1080             


Ile Glu  Glu Ile Glu Ile Asp  Leu Glu Glu Thr Glu  Arg Glu Ile 
    1085                 1090                 1095             


Ser Pro  Gln Glu Asn Gly Leu  Glu Glu Val Lys Pro  Leu Gly Glu 
    1100                 1105                 1110             


Met Gln  Thr Asp Leu Lys Ala  Thr Gly Arg Glu Ile  Ser Pro Arg 
    1115                 1120                 1125             


Glu Lys  Thr Pro Glu Val Ile  Asp Ala Thr Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Asp Leu  Glu Glu Thr Gly Arg  Arg Glu Ile Ser Pro  Glu Glu Asn 
    1145                 1150                 1155             


Gly Pro  Glu Glu Val Lys Pro  Val Asp Glu Met Glu  Thr Asp Leu 
    1160                 1165                 1170             


Lys Thr  Thr Gly Arg Glu Gly  Ser Ser Arg Glu Lys  Thr Arg Glu 
    1175                 1180                 1185             


Val Ile  Asp Ala Ala Glu Val  Ile Glu Thr Asp Leu  Glu Glu Thr 
    1190                 1195                 1200             


Glu Arg  Glu Ile Ser Pro Gln  Glu Asn Gly Pro Glu  Glu Val Lys 
    1205                 1210                 1215             


Pro Val  Gly Lys Met Glu Thr  Asp Leu Lys Glu Ile  Arg Glu Glu 
    1220                 1225                 1230             


Ile Ser  Gln Arg Glu Lys Val  Leu Ala Glu Phe Ser  Ala Ile Arg 
    1235                 1240                 1245             


Glu Lys  Glu Ile Asp Leu Lys  Glu Thr Gly Lys Arg  Asp Ile Pro 
    1250                 1255                 1260             


Ile Met  Glu Lys Val Ser Gly  Lys Met Ala Val Val  Glu Glu Met 
    1265                 1270                 1275             


Glu Ala  Asp Leu Lys Glu Thr  Gly Lys Glu Asn Phe  Arg Glu Arg 
    1280                 1285                 1290             


Gly Ser  Glu Glu Ile Cys Val  Thr Glu Glu Lys Val  Ala Glu Leu 
    1295                 1300                 1305             


Lys Gln  Thr Gly Lys Thr Asp  Ile Ser Pro Arg Glu  Asn Glu Leu 
    1310                 1315                 1320             


Glu Glu  Thr Ser Thr Ser Arg  Gln Thr Asp Thr His  Leu Met Gln 
    1325                 1330                 1335             


Ser Gly  Ser Asn Asp Phe Ser  Ala Val Pro Ser Leu  Asp Ile Gln 
    1340                 1345                 1350             


Asn Ile  Ser Ser Glu Val Leu  Ser Met Met His Thr  Pro Val Glu 
    1355                 1360                 1365             


Glu Lys  Arg Asn Ser Glu Lys  Glu Val Ser Ser His  Phe Ser His 
    1370                 1375                 1380             


Phe Lys  Ile Ser Ser Gln Thr  His Glu Ser Asp Lys  Thr Glu Val 
    1385                 1390                 1395             


Gln Gly  Ile Gln Ser Pro Asp  Val Pro Glu Gln Phe  Ser Asp Ile 
    1400                 1405                 1410             


Asn Leu  Ser Lys Ser Leu Pro  Gln Glu Gln Lys Pro  Leu Glu Ile 
    1415                 1420                 1425             


Lys Pro  Ala Pro Phe Val Arg  Ser Arg Phe Lys Arg  Pro Lys Pro 
    1430                 1435                 1440             


Asn Leu  Ala Arg Ala Ala Leu  Lys Arg Glu Thr Thr  Glu Ser Glu 
    1445                 1450                 1455             


Lys Tyr  Ile Tyr Glu Lys Lys  Ser Glu Thr Lys Lys  Met Glu Thr 
    1460                 1465                 1470             


Ile Val  Met Gln Glu Asn Asn  Glu Gln Thr Asp Thr  Leu Pro Ser 
    1475                 1480                 1485             


Gln His  Asp Glu Ala Ser Leu  Met Ile Ser Arg Glu  Lys Asp Thr 
    1490                 1495                 1500             


Leu Gly  His Arg Asn Glu Glu  Ala Val Ile Leu Pro  Cys Thr Gln 
    1505                 1510                 1515             


Thr Glu  Arg Asn Leu Ser Pro  Ser Asn Ser Cys Glu  Pro Lys Glu 
    1520                 1525                 1530             


Glu Ser  Gln Ser Ala Pro Val  Gln Lys Asn Asp Ser  Val Val Ser 
    1535                 1540                 1545             


Val Gly  Thr Asn Asn Val Asn  Thr Phe Gln Gln Glu  Met Lys Glu 
    1550                 1555                 1560             


Ser Val  Ile Gln Thr Ala Arg  Gln Val Arg Gly Arg  Leu Gln Arg 
    1565                 1570                 1575             


Pro Arg  Pro Asn Ile Arg Lys  Thr Gly Gln Arg Gln  Ile Val Asp 
    1580                 1585                 1590             


Lys Gly  Glu Ala Lys Gly Ile  Ile Lys Glu Gly Arg  Thr Ile Leu 
    1595                 1600                 1605             


Pro Lys  Asp Glu Thr Glu Lys  Lys Val Leu Thr Val  Ser Asn Ser 
    1610                 1615                 1620             


Gln Ile  Glu Thr Glu Ile Glu  Val Pro Ser Ser Ala  Val Pro Glu 
    1625                 1630                 1635             


His Arg  Met Tyr Glu Asn Gln  Ser Gln Val Val Leu  Val Glu Asn 
    1640                 1645                 1650             


Leu His  Val Asn Lys Thr Asn  Glu Thr Ile Arg His  Glu Asn Lys 
    1655                 1660                 1665             


Pro Tyr  Val Pro Ser Ser Ala  Gln Met Thr Arg Arg  Lys Phe Gln 
    1670                 1675                 1680             


Lys Ala  Lys Pro Asn Leu Gly  Arg Ala His Ser Lys  Lys Glu Glu 
    1685                 1690                 1695             


Pro Val  Leu Glu Lys Val Thr  Thr Asp Gln Ser Lys  Glu Gly Lys 
    1700                 1705                 1710             


Pro Glu  Asp His Leu Leu Gln  Lys Gly Ala Ser Asn  Thr Gln Leu 
    1715                 1720                 1725             


Leu Leu  Lys Glu Lys Ala Glu  Leu Leu Thr Ser Leu  Glu Val Ser 
    1730                 1735                 1740             


Ala Arg  Lys Asp Cys Val Gly  Ser Lys Glu Ser Ala  Leu Ala Lys 
    1745                 1750                 1755             


Ile Asp  Ala Glu Leu Glu Glu  Val Gly Pro Ser Arg  Arg Val Gly 
    1760                 1765                 1770             


Glu Glu  Thr Val Gly Asp Asn  Ser Pro Ser Ser Val  Val Glu Glu 
    1775                 1780                 1785             


Gln Tyr  Leu Asn Lys Leu Thr  Ser Cys Pro Gln Pro  Leu Asn Glu 
    1790                 1795                 1800             


Thr Ser  Tyr Ser Lys Ile Ala  Leu Asp Gly Lys Thr  Thr Ile Ser 
    1805                 1810                 1815             


Ser Thr  Ser Glu Tyr Glu Arg  Asn Arg Gly Glu Arg  Arg Ser His 
    1820                 1825                 1830             


Lys Lys  Phe Lys Pro Asn Val  Thr Arg Gly Arg Gly  Ser Lys Arg 
    1835                 1840                 1845             


Val Arg  Gly Lys Thr Ser Lys  Lys Glu Pro Arg Ala  Ser Lys Ala 
    1850                 1855                 1860             


Met Leu  Val Thr Leu Arg Ala  Ser Gln Glu Glu Asp  Asp Asp Ala 
    1865                 1870                 1875             


Asp Asp  Phe Glu Ser Asp Tyr  Glu Glu Glu Ser Tyr  His Leu Ala 
    1880                 1885                 1890             


Pro Glu  Glu Val Asn Lys Ala  Pro Val Phe Val Pro  Val Gly Leu 
    1895                 1900                 1905             


Arg Ser  Pro Glu Pro Val Ser  Ala Gln Ile Glu Glu  Thr Met Glu 
    1910                 1915                 1920             


Glu Leu  Glu Ile Thr Val Asn  Val Pro Asp Val Gly  Cys Ile Ala 
    1925                 1930                 1935             


Val Val  Glu His Glu Leu Pro  Asn Thr Asp Val Thr  Thr Glu Glu 
    1940                 1945                 1950             


Met Lys  Gln Glu Glu Asn Leu  Ser Val Pro Phe Glu  Met Thr Thr 
    1955                 1960                 1965             


Ser Glu  His Ile Gln Asp Glu  Pro Gly Thr Asn Asp  Gly Ser Thr 
    1970                 1975                 1980             


Glu Ala  Ala Ile Thr Leu Leu  Thr Met Gly Asp Leu  Val Leu Gln 
    1985                 1990                 1995             


Ser Glu  Ile Ser Ser Glu Gln  Gly Asp Val Gly Val  Cys Ile Ile 
    2000                 2005                 2010             


Pro His  Val His Ser Lys Asp  Lys Ser His Ile Pro  Ser Ser Leu 
    2015                 2020                 2025             


Asp Asn  Val Asn His Lys Ile  Val His Glu Cys Gln  Glu Leu Ser 
    2030                 2035                 2040             


Ser Pro  Val Ile Thr Thr Ser  Pro Ala Ser Phe Glu  Glu Asn Lys 
    2045                 2050                 2055             


Ile Val  Leu Glu Glu Gln Ser  Ser Arg Glu Glu Ile  Ser Leu Met 
    2060                 2065                 2070             


Glu Lys  Val Lys Glu Asn Ala  Thr Pro Thr Arg Asn  Thr Ile Ser 
    2075                 2080                 2085             


Lys Val  Thr Ser Asn Leu Arg  Ile Arg Ser Arg Leu  Ala Lys Pro 
    2090                 2095                 2100             


Lys Pro  Asn Leu Glu Lys Thr  Leu Gly Thr Asn Arg  Leu Asp Asp 
    2105                 2110                 2115             


Tyr Gln  Glu Val Ser Ser Leu  Cys Val Thr Lys Gly  Ala Glu Met 
    2120                 2125                 2130             


Glu Thr  Gln Arg Glu Thr Glu  Lys Asn Ala Ser Lys  Ala Thr Glu 
    2135                 2140                 2145             


Leu Glu  Asn Lys Asn Leu Gly  Pro Val Thr Thr Ala  Glu Asn Lys 
    2150                 2155                 2160             


Asp Gln  Ser Lys Leu Ala Cys  Val His Gly Ile Lys  Gly Thr Ser 
    2165                 2170                 2175             


Ile Ser  Ser Glu Val Asn Leu  Thr Glu Arg Asn Glu  Asn Gln Glu 
    2180                 2185                 2190             


Glu Ser  Ser Gln Glu Val His  Met Leu Ser Val Ala  Pro Val Ala 
    2195                 2200                 2205             


Ser Ser  Glu Thr Gly Pro Cys  Thr Leu Gly Leu Asp  Arg Gly Leu 
    2210                 2215                 2220             


Gly Glu  Asn Ser Val Glu Glu  Pro Gln Ile Lys Asp  Ser Lys Gly 
    2225                 2230                 2235             


Asp Ser  Val Leu Thr Leu Pro  Val Pro Glu Tyr Thr  Pro Thr Ser 
    2240                 2245                 2250             


Ile Pro  Glu Val Gln Gln Glu  Asn Ile Ile Asn Pro  Gln Asp Leu 
    2255                 2260                 2265             


Thr Val  Asn Leu Val Ala Asn  Val Pro Gln Asp Gly  Glu Asp Glu 
    2270                 2275                 2280             


Gln Ala  Phe Ile Leu Thr Leu  Val Glu Ile Pro Ala  Asn Ala Val 
    2285                 2290                 2295             


Glu Glu  Phe Thr Asp Ala Thr  Ala Gln Phe Met Pro  Asn Pro Leu 
    2300                 2305                 2310             


Leu Pro  Ala Pro Ile Leu Val  Lys Ser Val Asn Thr  Glu Glu Arg 
    2315                 2320                 2325             


Gly Asp  Met Ser Ile Cys Leu  Pro Ala Thr Ser Val  Gly Gln Asp 
    2330                 2335                 2340             


Ala Met  Gly Leu Ser Ile Ser  Gly Arg Asp Asn Ser  Lys Lys Pro 
    2345                 2350                 2355             


Pro Asp  Asn Leu Asp Leu Val  Ser Arg Lys Arg Phe  Gln Cys Arg 
    2360                 2365                 2370             


Leu Asp  Lys Asn Asp His Ile  Pro Pro Ala Lys Lys  Arg Ser Leu 
    2375                 2380                 2385             


Thr Leu  Arg Asp Asp Cys Gln  Glu Tyr Thr Thr Glu  Val His Ser 
    2390                 2395                 2400             


Lys Glu  Leu Thr Asn Val Phe  Glu Glu Thr Gly Glu  Ser His Lys 
    2405                 2410                 2415             


Gly Gln  Asp Ile Phe Leu Thr  Ser Gly Ser Thr Leu  Thr Thr Pro 
    2420                 2425                 2430             


Glu Pro  Gln Arg Gln Gln Val  Glu Ala Ala Phe Gln  Ser Arg Gly 
    2435                 2440                 2445             


Ser Arg  Ser Pro Asp Ala Cys  Met Asp Lys Asn Val  Pro Gln Leu 
    2450                 2455                 2460             


Pro Gln  Asp Glu Met Ile Val  Ser Asp Lys Glu Glu  Arg Thr Asp 
    2465                 2470                 2475             


Ala Ala  Pro Lys Ser Gln Gln  Met Asp Ser Arg Thr  Ser Ser Ser 
    2480                 2485                 2490             


Lys Ala  Ser Leu Ser Arg Pro  Gly Arg Arg Pro Leu  Gly Phe Leu 
    2495                 2500                 2505             


Ser Leu  Ile Cys Ser Lys Asn  Ser Leu Glu Ser Asp  Glu Pro Met 
    2510                 2515                 2520             


Gln Val  His Ser Lys Lys Arg  Leu Lys Pro Leu Ile  Pro Gly Leu 
    2525                 2530                 2535             


Arg Lys  Lys Leu Lys Arg Ser  Asn Pro Phe Asn Glu  Ser Gln Glu 
    2540                 2545                 2550             


Lys Asn  Arg Glu Ser Ser Asp  Leu Leu Pro Ser Pro  Ser Val Ile 
    2555                 2560                 2565             


Thr Thr  Gln Ser Glu Asn Ile  Ser Ser Ser Ala Thr  Gln Val Ser 
    2570                 2575                 2580             


Cys Asp  Gln Pro Leu Leu Lys  Glu Gly Tyr Lys Ser  Ala Gln Lys 
    2585                 2590                 2595             


Arg Ala  Pro Gln Gly Glu Ala  Thr Thr Val Ser Glu  Tyr Phe Phe 
    2600                 2605                 2610             


Asn Asp  Ile Phe Ile Glu Val  Asp Glu Thr Glu 
    2615                 2620                 


<210>  1128
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEAN1__Homo_sapiens__NP_001184154

<400>  1128

Met Arg Tyr Ala Cys Ser Ser Ser Glu Asp Trp Pro Pro Pro Leu Asp 
1               5                   10                  15      


Ile Ser Ser Asp Gly Asp Val Asp Ala Thr Val Leu Arg Glu Leu Tyr 
            20                  25                  30          


Pro Asp Ser Pro Pro Gly Val Ser Leu Ser Arg Leu Arg Trp Ser Ala 
        35                  40                  45              


Met Met Tyr Thr Gly Ser Phe Thr Tyr Trp Val Arg Ser Met Leu Ser 
    50                  55                  60                  


Arg His Lys Leu Asp Ala Ile Leu Gly Arg Leu Gly Tyr Thr Ala Thr 
65                  70                  75                  80  


Leu Glu Ser Glu Phe Ser Leu Val Gln Ala Ile Ser Lys Glu Asn Val 
                85                  90                  95      


Lys Gln Met Val Phe Lys Ile Phe Leu Val Arg Val Ser Cys Glu Ala 
            100                 105                 110         


Val Leu Arg Thr Ala Gly Thr Arg Met Leu Glu Pro Gly Thr Glu Lys 
        115                 120                 125             


Leu Ala Arg Thr His Ser Arg His Ser Ser Glu Lys Arg Leu Val Lys 
    130                 135                 140                 


Pro Cys Ser Cys Leu Glu Gly Val Gln Pro Gly Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Pro Gln Gln Gly Pro Ser Glu Gly Val Gly Ser Glu Thr Ala Leu Ala 
                165                 170                 175     


Glu Gly Thr Ala Gly Gln Arg Ser Leu Pro Met Ala Leu Ser Pro Ser 
            180                 185                 190         


Glu Val Ser Thr Ala Pro Asn Ser Leu Pro Ser Gly Ser Pro Val Leu 
        195                 200                 205             


<210>  1129
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEGAIN__Homo_sapiens__NP_001153003

<400>  1129

Met Glu Lys Leu Ser Ala Leu Gln Glu Gln Lys Gly Glu Leu Arg Lys 
1               5                   10                  15      


Arg Leu Ser Tyr Thr Thr His Lys Leu Glu Lys Leu Glu Thr Glu Phe 
            20                  25                  30          


Asp Ser Thr Arg His Tyr Leu Glu Ile Glu Leu Arg Arg Ala Gln Glu 
        35                  40                  45              


Glu Leu Glu Lys Val Thr Glu Lys Leu Arg Arg Ile Gln Ser Asn Tyr 
    50                  55                  60                  


Met Ala Leu Gln Arg Ile Asn Gln Glu Leu Glu Asp Lys Leu Tyr Arg 
65                  70                  75                  80  


Met Gly Gln His Tyr Glu Glu Glu Lys Arg Ala Leu Ser His Glu Ile 
                85                  90                  95      


Val Ala Leu Asn Ser His Leu Leu Glu Ala Lys Val Thr Ile Asp Lys 
            100                 105                 110         


Leu Ser Glu Asp Asn Glu Leu Tyr Arg Lys Asp Cys Asn Leu Ala Ala 
        115                 120                 125             


Gln Leu Leu Gln Cys Ser Gln Thr Tyr Gly Arg Val His Lys Val Ser 
    130                 135                 140                 


Glu Leu Pro Ser Asp Phe Gln Glu Arg Val Ser Leu His Met Glu Lys 
145                 150                 155                 160 


His Gly Cys Ser Leu Pro Ser Pro Leu Cys His Pro Ala Tyr Ala Asp 
                165                 170                 175     


Ser Val Pro Thr Cys Val Ile Ala Lys Val Leu Glu Lys Pro Asp Pro 
            180                 185                 190         


Ala Ser Leu Ser Ser Arg Leu Ser Asp Ala Ser Ala Arg Asp Leu Ala 
        195                 200                 205             


Phe Cys Asp Gly Val Glu Lys Pro Gly Pro Arg Pro Pro Tyr Lys Gly 
    210                 215                 220                 


Asp Ile Tyr Cys Ser Asp Thr Ala Leu Tyr Cys Pro Glu Glu Arg Arg 
225                 230                 235                 240 


Arg Asp Arg Arg Pro Ser Val Asp Ala Pro Val Thr Asp Val Gly Phe 
                245                 250                 255     


Leu Arg Ala Gln Asn Ser Thr Asp Ser Ala Ala Glu Glu Glu Glu Glu 
            260                 265                 270         


Ala Glu Ala Ala Ala Phe Pro Ala Gly Phe Gln His Glu Ala Phe Pro 
        275                 280                 285             


Ser Tyr Ala Gly Ser Leu Pro Thr Ser Ser Ser Tyr Ser Ser Phe Ser 
    290                 295                 300                 


Ala Thr Ser Glu Glu Lys Glu His Ala Gln Ala Ser Thr Leu Thr Ala 
305                 310                 315                 320 


Ser Gln Gln Ala Ile Tyr Leu Asn Ser Arg Asp Glu Leu Phe Asp Arg 
                325                 330                 335     


Lys Pro Pro Ala Thr Thr Tyr Glu Gly Ser Pro Arg Phe Ala Lys Ala 
            340                 345                 350         


Thr Ala Ala Val Ala Ala Pro Leu Glu Ala Glu Val Ala Pro Gly Phe 
        355                 360                 365             


Gly Arg Thr Met Ser Pro Tyr Pro Ala Glu Thr Phe Arg Phe Pro Ala 
    370                 375                 380                 


Ser Pro Gly Pro Gln Gln Ala Leu Met Pro Pro Asn Leu Trp Ser Leu 
385                 390                 395                 400 


Arg Ala Lys Pro Gly Thr Ala Arg Leu Pro Gly Glu Asp Met Arg Gly 
                405                 410                 415     


Gln Trp Arg Pro Leu Ser Val Glu Asp Ile Gly Ala Tyr Ser Tyr Pro 
            420                 425                 430         


Val Ser Ala Ala Gly Arg Ala Ser Pro Cys Ser Phe Ser Glu Arg Tyr 
        435                 440                 445             


Tyr Gly Gly Ala Gly Gly Ser Pro Gly Lys Lys Ala Asp Gly Arg Ala 
    450                 455                 460                 


Ser Pro Leu Tyr Ala Ser Tyr Lys Ala Asp Ser Phe Ser Glu Gly Asp 
465                 470                 475                 480 


Asp Leu Ser Gln Gly His Leu Ala Glu Pro Cys Phe Leu Arg Ala Gly 
                485                 490                 495     


Gly Asp Leu Ser Leu Ser Pro Gly Arg Ser Ala Asp Pro Leu Pro Gly 
            500                 505                 510         


Tyr Ala Pro Ser Glu Gly Gly Asp Gly Asp Arg Leu Gly Val Gln Leu 
        515                 520                 525             


Cys Gly Thr Ala Ser Ser Pro Glu Pro Glu Gln Gly Ser Arg Asp Ser 
    530                 535                 540                 


Leu Glu Pro Ser Ser Met Glu Ala Ser Pro Glu Met His Pro Ala Ala 
545                 550                 555                 560 


Arg Leu Ser Pro Gln Gln Ala Phe Pro Arg Thr Gly Gly Ser Gly Leu 
                565                 570                 575     


Ser Arg Lys Asp Ser Leu Thr Lys Ala Gln Leu Tyr Gly Thr Leu Leu 
            580                 585                 590         


Asn 
    


<210>  1130
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEND3__Homo_sapiens__NP_001073919

<400>  1130

Met Asn Ser Thr Glu Phe Thr Glu Asp Val Glu Glu Val Leu Lys Ser 
1               5                   10                  15      


Ile Thr Val Lys Val Glu Thr Glu Ala Glu Asp Ala Ala Leu Asp Cys 
            20                  25                  30          


Ser Val Asn Ser Arg Thr Ser Glu Lys His Ser Val Asp Ser Val Leu 
        35                  40                  45              


Thr Ala Leu Gln Asp Ser Ser Lys Arg Lys Gln Leu Val Ser Asp Gly 
    50                  55                  60                  


Leu Leu Asp Ser Val Pro Gly Val Lys Arg Arg Arg Leu Ile Pro Glu 
65                  70                  75                  80  


Ala Leu Leu Ala Gly Met Arg Asn Arg Glu Asn Ser Ser Pro Cys Gln 
                85                  90                  95      


Gly Asn Gly Glu Gln Ala Gly Arg Gly Arg Ser Leu Gly Asn Val Trp 
            100                 105                 110         


Pro Gly Glu Glu Glu Pro Cys Asn Asp Ala Thr Thr Pro Ser Tyr Lys 
        115                 120                 125             


Lys Pro Leu Tyr Gly Ile Ser His Lys Ile Met Glu Lys Lys Asn Pro 
    130                 135                 140                 


Pro Ser Gly Asp Leu Leu Asn Val Tyr Glu Leu Phe Glu Lys Ala Asn 
145                 150                 155                 160 


Ala Ser Asn Ser Pro Ser Ser Leu Arg Leu Leu Asn Glu Pro Gln Lys 
                165                 170                 175     


Arg Asp Cys Gly Ser Thr Gly Ala Gly Thr Asp Asn Asp Pro Asn Ile 
            180                 185                 190         


Tyr Phe Leu Ile Gln Lys Met Phe Tyr Met Leu Asn Thr Leu Thr Ser 
        195                 200                 205             


Asn Met Ser Gln Leu His Ser Lys Val Asp Leu Leu Ser Leu Glu Val 
    210                 215                 220                 


Ser Arg Ile Lys Lys Gln Val Ser Pro Thr Glu Met Val Ala Lys Phe 
225                 230                 235                 240 


Gln Pro Pro Pro Glu Tyr Gln Leu Thr Ala Ala Glu Leu Lys Gln Ile 
                245                 250                 255     


Val Asp Gln Ser Leu Ser Gly Gly Asp Leu Ala Cys Arg Leu Leu Val 
            260                 265                 270         


Gln Leu Phe Pro Glu Leu Phe Ser Asp Val Asp Phe Ser Arg Gly Cys 
        275                 280                 285             


Ser Ala Cys Gly Phe Ala Ala Lys Arg Lys Leu Glu Ser Leu His Leu 
    290                 295                 300                 


Gln Leu Ile Arg Asn Tyr Val Glu Val Tyr Tyr Pro Ser Val Lys Asp 
305                 310                 315                 320 


Thr Ala Val Trp Gln Ala Glu Cys Leu Pro Gln Leu Asn Asp Phe Phe 
                325                 330                 335     


Ser Arg Phe Trp Ala Gln Arg Glu Met Glu Asp Ser Gln Pro Ser Gly 
            340                 345                 350         


Gln Val Ala Ser Phe Phe Glu Ala Glu Gln Val Asp Pro Gly His Phe 
        355                 360                 365             


Leu Asp Asn Lys Asp Gln Glu Glu Ala Leu Ser Leu Asp Arg Ser Ser 
    370                 375                 380                 


Thr Ile Ala Ser Asp His Val Val Asp Thr Gln Asp Leu Thr Glu Phe 
385                 390                 395                 400 


Leu Asp Glu Ala Ser Ser Pro Gly Glu Phe Ala Val Phe Leu Leu His 
                405                 410                 415     


Arg Leu Phe Pro Glu Leu Phe Asp His Arg Lys Leu Gly Glu Gln Tyr 
            420                 425                 430         


Ser Cys Tyr Gly Asp Gly Gly Lys Gln Glu Leu Asp Pro Gln Arg Leu 
        435                 440                 445             


Gln Ile Ile Arg Asn Tyr Thr Glu Ile Tyr Phe Pro Asp Met Gln Glu 
    450                 455                 460                 


Glu Glu Ala Trp Leu Gln Gln Cys Ala Gln Arg Ile Asn Asp Glu Leu 
465                 470                 475                 480 


Glu Gly Leu Gly Leu Asp Ala Gly Ser Glu Gly Asp Pro Pro Arg Asp 
                485                 490                 495     


Asp Cys Tyr Asp Ser Ser Ser Leu Pro Asp Asp Ile Ser Val Val Lys 
            500                 505                 510         


Val Glu Asp Ser Phe Glu Gly Glu Arg Pro Gly Arg Arg Ser Lys Lys 
        515                 520                 525             


Ile Trp Leu Val Pro Ile Asp Phe Asp Lys Leu Glu Ile Pro Gln Pro 
    530                 535                 540                 


Asp Phe Glu Val Pro Gly Ala Asp Cys Leu Leu Ser Lys Glu Gln Leu 
545                 550                 555                 560 


Arg Ser Ile Tyr Glu Ser Ser Leu Ser Ile Gly Asn Phe Ala Ser Arg 
                565                 570                 575     


Leu Leu Val His Leu Phe Pro Glu Leu Phe Thr His Glu Asn Leu Arg 
            580                 585                 590         


Lys Gln Tyr Asn Cys Ser Gly Ser Leu Gly Lys Lys Gln Leu Asp Pro 
        595                 600                 605             


Ser Arg Ile Lys Leu Ile Arg His Tyr Val Gln Leu Leu Tyr Pro Arg 
    610                 615                 620                 


Ala Lys Asn Asp Arg Val Trp Thr Leu Glu Phe Val Gly Lys Leu Asp 
625                 630                 635                 640 


Glu Arg Cys Arg Arg Arg Asp Thr Glu Gln Arg Arg Ser Tyr Gln Gln 
                645                 650                 655     


Gln Arg Lys Val His Val Pro Gly Pro Glu Cys Arg Asp Leu Thr Ser 
            660                 665                 670         


Tyr Ala Ile Asn Pro Glu Arg Phe Arg Glu Glu Phe Glu Gly Pro Pro 
        675                 680                 685             


Leu Pro Pro Glu Arg Ser Ser Lys Asp Phe Cys Lys Ile Pro Leu Asp 
    690                 695                 700                 


Glu Leu Val Val Pro Ser Pro Asp Phe Pro Val Pro Ser Pro Tyr Leu 
705                 710                 715                 720 


Leu Ser Asp Lys Glu Val Arg Glu Ile Val Gln Gln Ser Leu Ser Val 
                725                 730                 735     


Gly Asn Phe Ala Ala Arg Leu Leu Val Arg Leu Phe Pro Glu Leu Phe 
            740                 745                 750         


Thr Ala Glu Asn Leu Arg Leu Gln Tyr Asn His Ser Gly Ala Cys Asn 
        755                 760                 765             


Lys Lys Gln Leu Asp Pro Thr Arg Leu Arg Leu Ile Arg His Tyr Val 
    770                 775                 780                 


Glu Ala Val Tyr Pro Val Glu Lys Met Glu Glu Val Trp His Tyr Glu 
785                 790                 795                 800 


Cys Ile Pro Ser Ile Asp Glu Arg Cys Arg Arg Pro Asn Arg Lys Lys 
                805                 810                 815     


Cys Asp Ile Leu Lys Lys Ala Lys Lys Val Glu Lys 
            820                 825             


<210>  1131
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEND4__Homo_sapiens__NP_001153019

<400>  1131

Met Glu Glu Glu Met Gln Pro Ala Glu Glu Gly Pro Ser Val Pro Lys 
1               5                   10                  15      


Ile Tyr Lys Gln Arg Ser Pro Tyr Ser Val Leu Lys Thr Phe Pro Ser 
            20                  25                  30          


Lys Arg Pro Ala Leu Ala Lys Arg Tyr Glu Arg Pro Thr Leu Val Glu 
        35                  40                  45              


Leu Pro His Val Arg Ala Pro Pro Pro Pro Pro Pro Pro Phe Ala Pro 
    50                  55                  60                  


His Ala Ala Val Ser Ile Ser Ser Ser Glu Pro Pro Pro Gln Gln Phe 
65                  70                  75                  80  


Gln Ala Gln Ser Ser Tyr Pro Pro Gly Pro Gly Arg Ala Ala Ala Ala 
                85                  90                  95      


Ala Ser Ser Ser Ser Pro Ser Cys Thr Pro Ala Thr Ser Gln Gly His 
            100                 105                 110         


Leu Arg Thr Pro Ala Gln Pro Pro Pro Ala Ser Pro Ala Ala Ser Ser 
        115                 120                 125             


Ser Ser Ser Phe Ala Ala Val Val Arg Tyr Gly Pro Gly Ala Ala Ala 
    130                 135                 140                 


Ala Ala Gly Thr Gly Gly Thr Gly Ser Asp Ser Ala Ser Leu Glu Leu 
145                 150                 155                 160 


Ser Ala Glu Ser Arg Met Ile Leu Asp Ala Phe Ala Gln Gln Cys Ser 
                165                 170                 175     


Arg Val Leu Ser Leu Leu Asn Cys Gly Gly Lys Leu Leu Asp Ser Asn 
            180                 185                 190         


His Ser Gln Ser Met Ile Ser Cys Val Lys Gln Glu Gly Ser Ser Tyr 
        195                 200                 205             


Asn Glu Arg Gln Glu His Cys His Ile Gly Lys Gly Val His Ser Gln 
    210                 215                 220                 


Thr Ser Asp Asn Val Asp Ile Glu Met Gln Tyr Met Gln Arg Lys Gln 
225                 230                 235                 240 


Gln Thr Ser Ala Phe Leu Arg Val Phe Thr Asp Ser Leu Gln Asn Tyr 
                245                 250                 255     


Leu Leu Ser Gly Ser Phe Pro Thr Pro Asn Pro Ser Ser Ala Ser Glu 
            260                 265                 270         


Tyr Gly His Leu Ala Asp Val Asp Pro Leu Ser Thr Ser Pro Val His 
        275                 280                 285             


Thr Leu Gly Gly Trp Thr Ser Pro Ala Thr Ser Glu Ser His Gly His 
    290                 295                 300                 


Pro Ser Ser Ser Thr Leu Pro Glu Glu Glu Glu Glu Glu Asp Glu Glu 
305                 310                 315                 320 


Gly Tyr Cys Pro Arg Cys Gln Glu Leu Glu Gln Glu Val Ile Ser Leu 
                325                 330                 335     


Gln Gln Glu Asn Glu Glu Leu Arg Arg Lys Leu Glu Ser Ile Pro Val 
            340                 345                 350         


Pro Cys Gln Thr Val Leu Asp Tyr Leu Lys Met Val Leu Gln His His 
        355                 360                 365             


Asn Gln Leu Leu Ile Pro Gln Pro Ala Asp Gln Pro Thr Glu Gly Ser 
    370                 375                 380                 


Lys Gln Leu Leu Asn Asn Tyr Pro Val Tyr Ile Thr Ser Lys Gln Trp 
385                 390                 395                 400 


Asp Glu Ala Val Asn Ser Ser Lys Lys Asp Gly Arg Arg Leu Leu Arg 
                405                 410                 415     


Tyr Leu Ile Arg Phe Val Phe Thr Thr Asp Glu Leu Lys Tyr Ser Cys 
            420                 425                 430         


Gly Leu Gly Lys Arg Lys Arg Ile His 
        435                 440     


<210>  1132
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEST1__Homo_sapiens__NP_001132915

<400>  1132

Met Phe Glu Lys Leu Thr Leu Tyr Cys Asp Ser Tyr Ile Gln Leu Ile 
1               5                   10                  15      


Pro Ile Ser Phe Val Leu Gly Phe Tyr Val Thr Leu Val Val Thr Arg 
            20                  25                  30          


Trp Trp Asn Gln Tyr Glu Asn Leu Pro Trp Pro Asp Arg Leu Met Ser 
        35                  40                  45              


Leu Val Ser Gly Phe Val Glu Gly Lys Asp Glu Gln Gly Arg Leu Leu 
    50                  55                  60                  


Arg Arg Thr Leu Ile Arg Tyr Ala Asn Leu Gly Asn Val Leu Ile Leu 
65                  70                  75                  80  


Arg Ser Val Ser Thr Ala Val Tyr Lys Arg Phe Pro Ser Ala Gln His 
                85                  90                  95      


Leu Val Gln Ala Gly Phe Met Thr Pro Ala Glu His Lys Gln Leu Glu 
            100                 105                 110         


Lys Leu Ser Leu Pro His Asn Met Phe Trp Val Pro Trp Val Trp Phe 
        115                 120                 125             


Ala Asn Leu Ser Met Lys Ala Trp Leu Gly Gly Arg Ile Arg Asp Pro 
    130                 135                 140                 


Ile Leu Leu Gln Ser Leu Leu Asn Glu Met Asn Thr Leu Arg Thr Gln 
145                 150                 155                 160 


Cys Gly His Leu Tyr Ala Tyr Asp Trp Ile Ser Ile Pro Leu Val Tyr 
                165                 170                 175     


Thr Gln Val Val Thr Val Ala Val Tyr Ser Phe Phe Leu Thr Cys Leu 
            180                 185                 190         


Val Gly Arg Gln Phe Leu Asn Pro Ala Lys Ala Tyr Pro Gly His Glu 
        195                 200                 205             


Leu Asp Leu Val Val Pro Val Phe Thr Phe Leu Gln Phe Phe Phe Tyr 
    210                 215                 220                 


Val Gly Trp Leu Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu 
225                 230                 235                 240 


Asp Asp Asp Asp Phe Glu Thr Asn Trp Ile Val Asp Arg Asn Leu Gln 
                245                 250                 255     


Val Ser Leu Leu Ala Val Asp Glu Met His Gln Asp Leu Pro Arg Met 
            260                 265                 270         


Glu Pro Asp Met Tyr Trp Asn Lys Pro Glu Pro Gln Pro Pro Tyr Thr 
        275                 280                 285             


Ala Ala Ser Ala Gln Phe Arg Arg Ala Ser Phe Met Gly Ser Thr Phe 
    290                 295                 300                 


Asn Ile Ser Leu Asn Lys Glu Glu Met Glu Phe Gln Pro Asn Gln Glu 
305                 310                 315                 320 


Asp Glu Glu Asp Ala His Ala Gly Ile Ile Gly Arg Phe Leu Gly Leu 
                325                 330                 335     


Gln Ser His Asp His His Pro Pro Arg Ala Asn Ser Arg Thr Lys Leu 
            340                 345                 350         


Leu Trp Pro Lys Arg Glu Ser Leu Leu His Glu Gly Leu Pro Lys Asn 
        355                 360                 365             


His Lys Ala Ala Lys Gln Asn Val Arg Gly Gln Glu Asp Asn Lys Ala 
    370                 375                 380                 


Trp Lys Leu Lys Ala Val Asp Ala Phe Lys Ser Ala Pro Leu Tyr Gln 
385                 390                 395                 400 


Arg Pro Gly Tyr Tyr Ser Ala Pro Gln Thr Pro Leu Ser Pro Thr Pro 
                405                 410                 415     


Met Phe Phe Pro Leu Glu Pro Ser Ala Pro Ser Lys Leu His Ser Val 
            420                 425                 430         


Thr Gly Ile Asp Thr Lys Asp Lys Ser Leu Lys Thr Val Ser Ser Gly 
        435                 440                 445             


Ala Lys Lys Ser Phe Glu Leu Leu Ser Glu Ser Asp Gly Ala Leu Met 
    450                 455                 460                 


Glu His Pro Glu Val Ser Gln Val Arg Arg Lys Thr Val Glu Phe Asn 
465                 470                 475                 480 


Leu Thr Asp Met Pro Glu Ile Pro Glu Asn His Leu Lys Glu Pro Leu 
                485                 490                 495     


Glu Gln Ser Pro Thr Asn Ile His Thr Thr Leu Lys Asp His Met Asp 
            500                 505                 510         


Pro Tyr Trp Ala Leu Glu Asn Arg Ser Val Leu His Leu Asn Gln Gly 
        515                 520                 525             


His Cys Ile Ala Leu Cys Pro Thr Pro Ala Ser Leu Ala Leu Ser Leu 
    530                 535                 540                 


Pro Phe Leu His Asn Phe Leu Gly Phe His His Cys Gln Ser Thr Leu 
545                 550                 555                 560 


Asp Leu Arg Pro Ala Leu Ala Trp Gly Ile Tyr Leu Ala Thr Phe Thr 
                565                 570                 575     


Gly Ile Leu Gly Lys Cys Ser Gly Pro Phe Leu Thr Ser Pro Trp Tyr 
            580                 585                 590         


His Pro Glu Asp Phe Leu Gly Pro Gly Glu Gly Arg 
        595                 600                 


<210>  1133
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEST2__Homo_sapiens__XP_005260020

<400>  1133

Met Thr Val Thr Tyr Thr Ala Arg Val Ala Asn Ala Arg Phe Gly Gly 
1               5                   10                  15      


Phe Ser Gln Leu Leu Leu Leu Trp Arg Gly Ser Ile Tyr Lys Leu Leu 
            20                  25                  30          


Trp Arg Glu Leu Leu Cys Phe Leu Gly Phe Tyr Met Ala Leu Ser Ala 
        35                  40                  45              


Ala Tyr Arg Phe Val Leu Thr Glu Gly Gln Lys Arg Tyr Phe Glu Lys 
    50                  55                  60                  


Leu Val Ile Tyr Cys Asp Gln Tyr Ala Ser Leu Ile Pro Val Ser Phe 
65                  70                  75                  80  


Val Leu Gly Phe Tyr Val Thr Leu Val Val Asn Arg Trp Trp Ser Gln 
                85                  90                  95      


Tyr Leu Cys Met Pro Leu Pro Asp Ala Leu Met Cys Val Val Ala Gly 
            100                 105                 110         


Thr Val His Gly Arg Asp Asp Arg Gly Arg Leu Tyr Arg Arg Thr Leu 
        115                 120                 125             


Met Arg Tyr Ala Gly Leu Ser Ala Val Leu Ile Leu Arg Ser Val Ser 
    130                 135                 140                 


Thr Ala Val Phe Lys Arg Phe Pro Thr Ile Asp His Val Val Glu Ala 
145                 150                 155                 160 


Gly Phe Met Thr Arg Glu Glu Arg Lys Lys Phe Glu Asn Leu Asn Ser 
                165                 170                 175     


Ser Tyr Asn Lys Tyr Trp Val Pro Cys Val Trp Phe Ser Asn Leu Ala 
            180                 185                 190         


Ala Gln Ala Arg Arg Glu Gly Arg Ile Arg Asp Asn Ser Ala Leu Lys 
        195                 200                 205             


Leu Leu Leu Glu Glu Leu Asn Val Phe Arg Gly Lys Cys Gly Met Leu 
    210                 215                 220                 


Phe His Tyr Asp Trp Ile Ser Val Pro Leu Val Tyr Thr Gln Val Val 
225                 230                 235                 240 


Thr Ile Ala Leu Tyr Ser Tyr Phe Leu Ala Cys Leu Ile Gly Arg Gln 
                245                 250                 255     


Phe Leu Asp Pro Ala Gln Gly Tyr Lys Asp His Asp Leu Asp Leu Cys 
            260                 265                 270         


Val Pro Ile Phe Thr Leu Leu Gln Phe Phe Phe Tyr Ala Gly Trp Leu 
        275                 280                 285             


Lys Val Ala Glu Gln Leu Ile Asn Pro Phe Gly Glu Asp Asp Asp Asp 
    290                 295                 300                 


Phe Glu Thr Asn Phe Leu Ile Asp Arg Asn Phe Gln Val Ser Met Leu 
305                 310                 315                 320 


Ala Val Asp Glu Met Tyr Asp Asp Leu Ala Val Leu Glu Lys Asp Leu 
                325                 330                 335     


Tyr Trp Asp Ala Ala Glu Ala Arg Ala Pro Tyr Thr Ala Ala Thr Val 
            340                 345                 350         


Phe Gln Leu Arg Gln Pro Ser Phe Gln Gly Ser Thr Phe Asp Ile Thr 
        355                 360                 365             


Leu Ala Lys Glu Asp Met Gln Phe Gln Arg Leu Asp Gly Leu Asp Gly 
    370                 375                 380                 


Pro Met Gly Glu Ala Pro Gly Asp Phe Leu Gln Arg Leu Leu Pro Ala 
385                 390                 395                 400 


Gly Ala Gly Met Val Ala Gly Gly Pro Leu Gly Arg Arg Leu Ser Phe 
                405                 410                 415     


Leu Leu Arg Lys Asn Ser Cys Val Ser Glu Ala Ser Thr Gly Ala Ser 
            420                 425                 430         


Cys Ser Cys Ala Val Val Pro Glu Gly Ala Ala Pro Glu Cys Ser Cys 
        435                 440                 445             


Gly Asp Pro Leu Leu Asp Pro Gly Leu Pro Glu Pro Glu Ala Pro Pro 
    450                 455                 460                 


Pro Ala Gly Pro Glu Pro Leu Thr Leu Ile Pro Gly Pro Val Glu Pro 
465                 470                 475                 480 


Phe Ser Ile Val Thr Met Pro Gly Pro Arg Gly Pro Ala Pro Pro Trp 
                485                 490                 495     


Leu Pro Ser Pro Ile Gly Glu Glu Glu Glu Asn Leu Ala 
            500                 505                 


<210>  1134
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET1__Homo_sapiens__NP_005859

<400>  1134

Met Arg Arg Ala Gly Leu Gly Glu Gly Val Pro Pro Gly Asn Tyr Gly 
1               5                   10                  15      


Asn Tyr Gly Tyr Ala Asn Ser Gly Tyr Ser Ala Cys Glu Glu Glu Asn 
            20                  25                  30          


Glu Arg Leu Thr Glu Ser Leu Arg Ser Lys Val Thr Ala Ile Lys Ser 
        35                  40                  45              


Leu Ser Ile Glu Ile Gly His Glu Val Lys Thr Gln Asn Lys Leu Leu 
    50                  55                  60                  


Ala Glu Met Asp Ser Gln Phe Asp Ser Thr Thr Gly Phe Leu Gly Lys 
65                  70                  75                  80  


Thr Met Gly Lys Leu Lys Ile Leu Ser Arg Gly Ser Gln Thr Lys Leu 
                85                  90                  95      


Leu Cys Tyr Met Met Leu Phe Ser Leu Phe Val Phe Phe Ile Ile Tyr 
            100                 105                 110         


Trp Ile Ile Lys Leu Arg 
        115             


<210>  1135
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET1L__Homo_sapiens__NP_001092257

<400>  1135

Met Ala Asp Trp Ala Arg Ala Gln Ser Pro Gly Ala Val Glu Glu Ile 
1               5                   10                  15      


Leu Asp Arg Glu Asn Lys Arg Met Ala Asp Ser Leu Ala Ser Lys Val 
            20                  25                  30          


Thr Arg Leu Lys Ser Leu Ala Leu Asp Ile Asp Arg Asp Ala Glu Asp 
        35                  40                  45              


Gln Asn Arg Tyr Leu Asp Gly Met Asp Ser Asp Phe Thr Ser Met Thr 
    50                  55                  60                  


Ser Leu Leu Thr Gly Ser Val Lys Arg Phe Ser Thr Met Ala Arg Ser 
65                  70                  75                  80  


Gly Gln Asp Asn Arg Lys Leu Leu Cys Gly Met Ala Val Gly Leu Ile 
                85                  90                  95      


Val Ala Phe Phe Ile Leu Ser Tyr Phe Leu Ser Arg Ala Arg Thr 
            100                 105                 110     


<210>  1136
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEX1__Homo_sapiens__NP_060946

<400>  1136

Met Glu Ser Lys Glu Lys Arg Ala Val Asn Ser Leu Ser Met Glu Asn 
1               5                   10                  15      


Ala Asn Gln Glu Asn Glu Glu Lys Glu Gln Val Ala Asn Lys Gly Glu 
            20                  25                  30          


Pro Leu Ala Leu Pro Leu Asp Ala Gly Glu Tyr Cys Val Pro Arg Gly 
        35                  40                  45              


Asn Arg Arg Arg Phe Arg Val Arg Gln Pro Ile Leu Gln Tyr Arg Trp 
    50                  55                  60                  


Asp Met Met His Arg Leu Gly Glu Pro Gln Ala Arg Met Arg Glu Glu 
65                  70                  75                  80  


Asn Met Glu Arg Ile Gly Glu Glu Val Arg Gln Leu Met Glu Lys Leu 
                85                  90                  95      


Arg Glu Lys Gln Leu Ser His Ser Leu Arg Ala Val Ser Thr Asp Pro 
            100                 105                 110         


Pro His His Asp His His Asp Glu Phe Cys Leu Met Pro 
        115                 120                 125 


<210>  1137
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEX2__Homo_sapiens__NP_001161871

<400>  1137

Met Gln Lys Met Val Val Cys Gly Ala Lys Cys Cys Gly Asp Ala Pro 
1               5                   10                  15      


His Val Glu Asn Arg Glu Glu Glu Thr Ala Arg Ile Gly Pro Gly Val 
            20                  25                  30          


Met Glu Ser Lys Glu Glu Arg Ala Leu Asn Asn Leu Ile Val Glu Asn 
        35                  40                  45              


Val Asn Gln Glu Asn Asp Glu Lys Asp Glu Lys Glu Gln Val Ala Asn 
    50                  55                  60                  


Lys Gly Glu Pro Leu Ala Leu Pro Leu Asn Val Ser Glu Tyr Cys Val 
65                  70                  75                  80  


Pro Arg Gly Asn Arg Arg Arg Phe Arg Val Arg Gln Pro Ile Leu Gln 
                85                  90                  95      


Tyr Arg Trp Asp Ile Met His Arg Leu Gly Glu Pro Gln Ala Arg Met 
            100                 105                 110         


Arg Glu Glu Asn Met Glu Arg Ile Gly Glu Glu Val Arg Gln Leu Met 
        115                 120                 125             


Glu Lys Leu Arg Glu Lys Gln Leu Ser His Ser Leu Arg Ala Val Ser 
    130                 135                 140                 


Thr Asp Pro Pro His His Asp His His Asp Glu Phe Cys Leu Met Pro 
145                 150                 155                 160 


<210>  1138
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BEX4__Homo_sapiens__NP_001073894

<400>  1138

Met Glu Ser Lys Glu Glu Leu Ala Ala Asn Asn Leu Asn Gly Glu Asn 
1               5                   10                  15      


Ala Gln Gln Glu Asn Glu Gly Gly Glu Gln Ala Pro Thr Gln Asn Glu 
            20                  25                  30          


Glu Glu Ser Arg His Leu Gly Gly Gly Glu Gly Gln Lys Pro Gly Gly 
        35                  40                  45              


Asn Ile Arg Arg Gly Arg Val Arg Arg Leu Val Pro Asn Phe Arg Trp 
    50                  55                  60                  


Ala Ile Pro Asn Arg His Ile Glu His Asn Glu Ala Arg Asp Asp Val 
65                  70                  75                  80  


Glu Arg Phe Val Gly Gln Met Met Glu Ile Lys Arg Lys Thr Arg Glu 
                85                  90                  95      


Gln Gln Met Arg His Tyr Met Arg Phe Gln Thr Pro Glu Pro Asp Asn 
            100                 105                 110         


His Tyr Asp Phe Cys Leu Ile Pro 
        115                 120 


<210>  1139
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BFAR__Homo_sapiens__NP_057645

<400>  1139

Met Glu Glu Pro Gln Lys Ser Tyr Val Asn Thr Met Asp Leu Glu Arg 
1               5                   10                  15      


Asp Glu Pro Leu Lys Ser Thr Gly Pro Gln Ile Ser Val Ser Glu Phe 
            20                  25                  30          


Ser Cys His Cys Cys Tyr Asp Ile Leu Val Asn Pro Thr Thr Leu Asn 
        35                  40                  45              


Cys Gly His Ser Phe Cys Arg His Cys Leu Ala Leu Trp Trp Ala Ser 
    50                  55                  60                  


Ser Lys Lys Thr Glu Cys Pro Glu Cys Arg Glu Lys Trp Glu Gly Phe 
65                  70                  75                  80  


Pro Lys Val Ser Ile Leu Leu Arg Asp Ala Ile Glu Lys Leu Phe Pro 
                85                  90                  95      


Asp Ala Ile Arg Leu Arg Phe Glu Asp Ile Gln Gln Asn Asn Asp Ile 
            100                 105                 110         


Val Gln Ser Leu Ala Ala Phe Gln Lys Tyr Gly Asn Asp Gln Ile Pro 
        115                 120                 125             


Leu Ala Pro Asn Thr Gly Arg Ala Asn Gln Gln Met Gly Gly Gly Phe 
    130                 135                 140                 


Phe Ser Gly Val Leu Thr Ala Leu Thr Gly Val Ala Val Val Leu Leu 
145                 150                 155                 160 


Val Tyr His Trp Ser Ser Arg Glu Ser Glu His Asp Leu Leu Val His 
                165                 170                 175     


Lys Ala Val Ala Lys Trp Thr Ala Glu Glu Val Val Leu Trp Leu Glu 
            180                 185                 190         


Gln Leu Gly Pro Trp Ala Ser Leu Tyr Arg Glu Arg Phe Leu Ser Glu 
        195                 200                 205             


Arg Val Asn Gly Arg Leu Leu Leu Thr Leu Thr Glu Glu Glu Phe Ser 
    210                 215                 220                 


Lys Thr Pro Tyr Thr Ile Glu Asn Ser Ser His Arg Arg Ala Ile Leu 
225                 230                 235                 240 


Met Glu Leu Glu Arg Val Lys Ala Leu Gly Val Lys Pro Pro Gln Asn 
                245                 250                 255     


Leu Trp Glu Tyr Lys Ala Val Asn Pro Gly Arg Ser Leu Phe Leu Leu 
            260                 265                 270         


Tyr Ala Leu Lys Ser Ser Pro Arg Leu Ser Leu Leu Tyr Leu Tyr Leu 
        275                 280                 285             


Phe Asp Tyr Thr Asp Thr Phe Leu Pro Phe Ile His Thr Ile Cys Pro 
    290                 295                 300                 


Leu Gln Glu Asp Ser Ser Gly Glu Asp Ile Val Thr Lys Leu Leu Asp 
305                 310                 315                 320 


Leu Lys Glu Pro Thr Trp Lys Gln Trp Arg Glu Phe Leu Val Lys Tyr 
                325                 330                 335     


Ser Phe Leu Pro Tyr Gln Leu Ile Ala Glu Phe Ala Trp Asp Trp Leu 
            340                 345                 350         


Glu Val His Tyr Trp Thr Ser Arg Phe Leu Ile Ile Asn Ala Met Leu 
        355                 360                 365             


Leu Ser Val Leu Glu Leu Phe Ser Phe Trp Arg Ile Trp Ser Arg Ser 
    370                 375                 380                 


Glu Leu Lys Thr Val Pro Gln Arg Met Trp Ser His Phe Trp Lys Val 
385                 390                 395                 400 


Ser Thr Gln Gly Leu Phe Val Ala Met Phe Trp Pro Leu Ile Pro Gln 
                405                 410                 415     


Phe Val Cys Asn Cys Leu Phe Tyr Trp Ala Leu Tyr Phe Asn Pro Ile 
            420                 425                 430         


Ile Asn Ile Asp Leu Val Val Lys Glu Leu Arg Arg Leu Glu Thr Gln 
        435                 440                 445             


Val Leu 
    450 


<210>  1140
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BFSP1__Homo_sapiens__NP_001155177

<400>  1140

Met Tyr Glu Asn Glu Cys Glu Cys Gln Leu Leu Leu Lys Glu Met Leu 
1               5                   10                  15      


Glu Arg Leu Asn Lys Glu Ala Asp Glu Ala Leu Leu His Asn Leu Arg 
            20                  25                  30          


Leu Gln Leu Glu Ala Gln Phe Leu Gln Asp Asp Ile Ser Ala Ala Lys 
        35                  40                  45              


Asp Arg His Lys Lys Asn Leu Leu Glu Val Gln Thr Tyr Ile Ser Ile 
    50                  55                  60                  


Leu Gln Gln Ile Ile His Thr Thr Pro Pro Ala Ser Ile Val Thr Ser 
65                  70                  75                  80  


Gly Met Arg Glu Glu Lys Leu Leu Thr Glu Arg Glu Val Ala Ala Leu 
                85                  90                  95      


Arg Ser Gln Leu Glu Glu Gly Arg Glu Val Leu Ser His Leu Gln Ala 
            100                 105                 110         


Gln Arg Val Glu Leu Gln Ala Gln Thr Thr Thr Leu Glu Gln Ala Ile 
        115                 120                 125             


Lys Ser Ala His Glu Cys Tyr Asp Asp Glu Ile Gln Leu Tyr Asn Glu 
    130                 135                 140                 


Gln Ile Glu Thr Leu Arg Lys Glu Ile Glu Glu Thr Glu Arg Val Leu 
145                 150                 155                 160 


Glu Lys Ser Ser Tyr Asp Cys Arg Gln Leu Ala Val Ala Gln Gln Thr 
                165                 170                 175     


Leu Lys Asn Glu Leu Asp Arg Tyr His Arg Ile Ile Glu Ile Glu Gly 
            180                 185                 190         


Asn Arg Leu Thr Ser Ala Phe Ile Glu Thr Pro Ile Pro Leu Phe Thr 
        195                 200                 205             


Gln Ser His Gly Val Ser Leu Ser Thr Gly Ser Gly Gly Lys Asp Leu 
    210                 215                 220                 


Thr Arg Ala Leu Gln Asp Ile Thr Ala Ala Lys Pro Arg Gln Lys Ala 
225                 230                 235                 240 


Leu Pro Lys Asn Val Pro Arg Arg Lys Glu Ile Ile Thr Lys Asp Lys 
                245                 250                 255     


Thr Asn Gly Ala Leu Glu Asp Ala Pro Leu Lys Gly Leu Glu Asp Thr 
            260                 265                 270         


Lys Leu Val Gln Val Val Leu Lys Glu Glu Ser Glu Ser Lys Phe Glu 
        275                 280                 285             


Ser Glu Ser Lys Glu Val Ser Pro Leu Thr Gln Glu Gly Ala Pro Glu 
    290                 295                 300                 


Asp Val Pro Asp Gly Gly Gln Ile Ser Lys Gly Phe Gly Lys Leu Tyr 
305                 310                 315                 320 


Arg Lys Val Lys Glu Lys Val Arg Ser Pro Lys Glu Pro Glu Thr Pro 
                325                 330                 335     


Thr Glu Leu Tyr Thr Lys Glu Arg His Val Leu Val Thr Gly Asp Ala 
            340                 345                 350         


Asn Tyr Val Asp Pro Arg Phe Tyr Val Ser Ser Ile Thr Ala Lys Gly 
        355                 360                 365             


Gly Val Ala Val Ser Val Ala Glu Asp Ser Val Leu Tyr Asp Gly Gln 
    370                 375                 380                 


Val Glu Pro Ser Pro Glu Ser Pro Lys Pro Pro Leu Glu Asn Gly Gln 
385                 390                 395                 400 


Val Gly Leu Gln Glu Lys Glu Asp Gly Gln Pro Ile Asp Gln Gln Pro 
                405                 410                 415     


Ile Asp Lys Glu Ile Glu Pro Asp Gly Ala Glu Leu Glu Gly Pro Glu 
            420                 425                 430         


Glu Lys Arg Glu Gly Glu Glu Arg Asp Glu Glu Ser Arg Arg Pro Cys 
        435                 440                 445             


Ala Met Val Thr Pro Gly Ala Glu Glu Pro Ser Ile Pro Glu Pro Pro 
    450                 455                 460                 


Lys Pro Ala Ala Asp Gln Asp Gly Ala Glu Val Leu Gly Thr Arg Ser 
465                 470                 475                 480 


Arg Ser Leu Pro Glu Lys Gly Pro Pro Lys Ala Leu Ala Tyr Lys Thr 
                485                 490                 495     


Val Glu Val Val Glu Ser Ile Glu Lys Ile Ser Thr Glu Ser Ile Gln 
            500                 505                 510         


Thr Tyr Glu Glu Thr Ala Val Ile Val Glu Thr Met Ile Gly Lys Thr 
        515                 520                 525             


Lys Ser Asp Lys Lys Lys Ser Gly Glu Lys Ser Ser 
    530                 535                 540 


<210>  1141
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BFSP2__Homo_sapiens__NP_003562

<400>  1141

Met Ser Glu Arg Arg Val Val Val Asp Leu Pro Thr Ser Ala Ser Ser 
1               5                   10                  15      


Ser Met Pro Leu Gln Arg Arg Arg Ala Ser Phe Arg Gly Pro Arg Ser 
            20                  25                  30          


Ser Ser Ser Leu Glu Ser Pro Pro Ala Ser Arg Thr Asn Ala Met Ser 
        35                  40                  45              


Gly Leu Val Arg Ala Pro Gly Val Tyr Val Gly Thr Ala Pro Ser Gly 
    50                  55                  60                  


Cys Ile Gly Gly Leu Gly Ala Arg Val Thr Arg Arg Ala Leu Gly Ile 
65                  70                  75                  80  


Ser Ser Val Phe Leu Gln Gly Leu Arg Ser Ser Gly Leu Ala Thr Val 
                85                  90                  95      


Pro Ala Pro Gly Leu Glu Arg Asp His Gly Ala Val Glu Asp Leu Gly 
            100                 105                 110         


Gly Cys Leu Val Glu Tyr Met Ala Lys Val His Ala Leu Glu Gln Val 
        115                 120                 125             


Ser Gln Glu Leu Glu Thr Gln Leu Arg Met His Leu Glu Ser Lys Ala 
    130                 135                 140                 


Thr Arg Ser Gly Asn Trp Gly Ala Leu Arg Ala Ser Trp Ala Ser Ser 
145                 150                 155                 160 


Cys Gln Gln Val Gly Glu Ala Val Leu Glu Asn Ala Arg Leu Met Leu 
                165                 170                 175     


Gln Thr Glu Thr Ile Gln Ala Gly Ala Asp Asp Phe Lys Glu Arg Tyr 
            180                 185                 190         


Glu Asn Glu Gln Pro Phe Arg Lys Ala Ala Glu Glu Glu Ile Asn Ser 
        195                 200                 205             


Leu Tyr Lys Val Ile Asp Glu Ala Asn Leu Thr Lys Met Asp Leu Glu 
    210                 215                 220                 


Ser Gln Ile Glu Ser Leu Lys Glu Glu Leu Gly Ser Leu Ser Arg Asn 
225                 230                 235                 240 


Tyr Glu Glu Asp Val Lys Leu Leu His Lys Gln Leu Ala Gly Cys Glu 
                245                 250                 255     


Leu Glu Gln Met Asp Ala Pro Ile Gly Thr Gly Leu Asp Asp Ile Leu 
            260                 265                 270         


Glu Thr Ile Arg Ile Gln Trp Glu Arg Asp Val Glu Lys Asn Arg Val 
        275                 280                 285             


Glu Ala Gly Ala Leu Leu Gln Ala Lys Gln Gln Ala Glu Val Ala His 
    290                 295                 300                 


Met Ser Gln Thr Gln Glu Glu Lys Leu Ala Ala Ala Leu Arg Val Glu 
305                 310                 315                 320 


Leu His Asn Thr Ser Cys Gln Val Gln Ser Leu Gln Ala Glu Thr Glu 
                325                 330                 335     


Ser Leu Arg Ala Leu Lys Arg Gly Leu Glu Asn Thr Leu His Asp Ala 
            340                 345                 350         


Lys His Trp His Asp Met Glu Leu Gln Asn Leu Gly Ala Val Val Gly 
        355                 360                 365             


Arg Leu Glu Ala Glu Leu Arg Glu Ile Arg Ala Glu Ala Glu Gln Gln 
    370                 375                 380                 


Gln Gln Glu Arg Ala His Leu Leu Ala Arg Lys Cys Gln Leu Gln Lys 
385                 390                 395                 400 


Asp Val Ala Ser Tyr His Ala Leu Leu Asp Arg Glu Glu Ser Gly 
                405                 410                 415 


<210>  1142
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGLAP__Homo_sapiens__NP_954642

<400>  1142

Met Arg Ala Leu Thr Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210>  1143
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGN__Homo_sapiens__NP_001702

<400>  1143

Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys 
        115                 120                 125             


Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr 
    130                 135                 140                 


Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser 
145                 150                 155                 160 


Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
                165                 170                 175     


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            180                 185                 190         


Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu 
        195                 200                 205             


Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro 
    210                 215                 220                 


Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys 
225                 230                 235                 240 


Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr 
                245                 250                 255     


Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser 
            260                 265                 270         


Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
        275                 280                 285             


Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
    290                 295                 300                 


Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe 
305                 310                 315                 320 


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
                325                 330                 335     


Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe 
            340                 345                 350         


Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
        355                 360                 365             


<210>  1144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHLHA15__Homo_sapiens__NP_803238

<400>  1144

Met Lys Thr Lys Asn Arg Pro Pro Arg Arg Arg Ala Pro Val Gln Asp 
1               5                   10                  15      


Thr Glu Ala Thr Pro Gly Glu Gly Thr Pro Asp Gly Ser Leu Pro Asn 
            20                  25                  30          


Pro Gly Pro Glu Pro Ala Lys Gly Leu Arg Ser Arg Pro Ala Arg Ala 
        35                  40                  45              


Ala Ala Arg Ala Pro Gly Glu Gly Arg Arg Arg Arg Pro Gly Pro Ser 
    50                  55                  60                  


Gly Pro Gly Gly Arg Arg Asp Ser Ser Ile Gln Arg Arg Leu Glu Ser 
65                  70                  75                  80  


Asn Glu Arg Glu Arg Gln Arg Met His Lys Leu Asn Asn Ala Phe Gln 
                85                  90                  95      


Ala Leu Arg Glu Val Ile Pro His Val Arg Ala Asp Lys Lys Leu Ser 
            100                 105                 110         


Lys Ile Glu Thr Leu Thr Leu Ala Lys Asn Tyr Ile Lys Ser Leu Thr 
        115                 120                 125             


Ala Thr Ile Leu Thr Met Ser Ser Ser Arg Leu Pro Gly Leu Glu Gly 
    130                 135                 140                 


Pro Gly Pro Lys Leu Tyr Gln His Tyr Gln Gln Gln Gln Gln Val Ala 
145                 150                 155                 160 


Gly Gly Ala Leu Gly Ala Thr Glu Ala Gln Pro Gln Gly His Leu Gln 
                165                 170                 175     


Arg Tyr Ser Thr Gln Ile His Ser Phe Arg Glu Gly Thr 
            180                 185                 


<210>  1145
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHLHA9__Homo_sapiens__NP_001157877

<400>  1145

Met Leu Arg Gly Ala Pro Gly Leu Gly Leu Thr Ala Arg Lys Gly Ala 
1               5                   10                  15      


Glu Asp Ser Ala Glu Asp Leu Gly Gly Pro Cys Pro Glu Pro Gly Gly 
            20                  25                  30          


Asp Ser Gly Val Leu Gly Ala Asn Gly Ala Ser Cys Ser Arg Gly Glu 
        35                  40                  45              


Ala Glu Glu Pro Ala Gly Arg Arg Arg Ala Arg Pro Val Arg Ser Lys 
    50                  55                  60                  


Ala Arg Arg Met Ala Ala Asn Val Arg Glu Arg Lys Arg Ile Leu Asp 
65                  70                  75                  80  


Tyr Asn Glu Ala Phe Asn Ala Leu Arg Arg Ala Leu Arg His Asp Leu 
                85                  90                  95      


Gly Gly Lys Arg Leu Ser Lys Ile Ala Thr Leu Arg Arg Ala Ile His 
            100                 105                 110         


Arg Ile Ala Ala Leu Ser Leu Val Leu Arg Ala Ser Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Cys Gly His Leu Glu Cys His Gly Pro Ala Ala Arg Gly Asp 
    130                 135                 140                 


Thr Gly Asp Thr Gly Ala Ser Pro Pro Pro Pro Ala Gly Pro Ser Leu 
145                 150                 155                 160 


Ala Arg Pro Asp Ala Ala Arg Pro Ser Val Pro Ser Ala Pro Arg Cys 
                165                 170                 175     


Ala Ser Cys Pro Pro His Ala Pro Leu Ala Arg Pro Ser Ala Val Ala 
            180                 185                 190         


Glu Gly Pro Gly Leu Ala Gln Ala Ser Gly Gly Ser Trp Arg Arg Cys 
        195                 200                 205             


Pro Gly Ala Ser Ser Ala Gly Pro Pro Pro Trp Pro Arg Gly Tyr Leu 
    210                 215                 220                 


Arg Ser Ala Pro Gly Met Gly His Pro Arg Ser 
225                 230                 235 


<210>  1146
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHLHB9__Homo_sapiens__NP_001135999

<400>  1146

Met Ala Gly Thr Lys Asn Lys Thr Arg Ala Gln Ala Lys Thr Glu Lys 
1               5                   10                  15      


Lys Ala Ala Ile Gln Ala Lys Ala Gly Ala Glu Arg Glu Ala Thr Gly 
            20                  25                  30          


Val Val Arg Pro Val Ala Lys Thr Arg Ala Lys Ala Lys Ala Lys Thr 
        35                  40                  45              


Gly Ser Lys Thr Asp Ala Val Ala Glu Met Lys Ala Val Ser Lys Asn 
    50                  55                  60                  


Lys Val Val Ala Glu Thr Lys Glu Gly Ala Leu Ser Glu Pro Lys Thr 
65                  70                  75                  80  


Leu Gly Lys Ala Met Gly Asp Phe Thr Pro Lys Ala Gly Asn Glu Ser 
                85                  90                  95      


Thr Ser Ser Thr Cys Lys Asn Glu Ala Gly Thr Asp Ala Trp Phe Trp 
            100                 105                 110         


Ala Gly Glu Glu Ala Thr Ile Asn Ser Trp Phe Trp Asn Gly Glu Glu 
        115                 120                 125             


Ala Gly Asn Ser Phe Ser Thr Lys Asn Asp Lys Pro Glu Ile Gly Ala 
    130                 135                 140                 


Gln Val Cys Ala Glu Glu Leu Glu Pro Ala Ala Gly Ala Asp Cys Lys 
145                 150                 155                 160 


Pro Arg Ser Gly Ala Glu Glu Glu Glu Glu Glu Asn Val Ile Gly Asn 
                165                 170                 175     


Trp Phe Trp Glu Gly Asp Asp Thr Ser Phe Asp Pro Asn Pro Lys Pro 
            180                 185                 190         


Val Ser Arg Ile Val Lys Pro Gln Pro Val Tyr Glu Ile Asn Glu Lys 
        195                 200                 205             


Asn Arg Pro Lys Asp Trp Ser Glu Val Thr Ile Trp Pro Asn Ala Pro 
    210                 215                 220                 


Ala Val Thr Pro Ala Val Leu Gly Phe Arg Ser Gln Ala Pro Ser Glu 
225                 230                 235                 240 


Ala Ser Pro Pro Ser Tyr Ile Val Leu Ala Ser Ala Glu Glu Asn Ala 
                245                 250                 255     


Cys Ser Leu Pro Val Ala Thr Ala Cys Arg Pro Ser Arg Asn Thr Arg 
            260                 265                 270         


Ser Cys Ser Gln Pro Ile Pro Glu Cys Arg Phe Asp Ser Asp Pro Cys 
        275                 280                 285             


Ile Gln Thr Ile Asp Glu Ile Arg Arg Gln Ile Arg Ile Arg Glu Val 
    290                 295                 300                 


Asn Gly Ile Lys Pro Phe Ala Cys Pro Cys Lys Met Glu Cys Tyr Met 
305                 310                 315                 320 


Asp Ser Glu Glu Phe Glu Lys Leu Val Ser Leu Leu Lys Ser Thr Thr 
                325                 330                 335     


Asp Pro Leu Ile His Lys Ile Ala Arg Ile Ala Met Gly Val His Asn 
            340                 345                 350         


Val His Pro Phe Ala Gln Glu Phe Ile Asn Glu Val Gly Val Val Thr 
        355                 360                 365             


Leu Ile Glu Ser Leu Leu Ser Phe Pro Ser Pro Glu Met Arg Lys Lys 
    370                 375                 380                 


Thr Val Ile Thr Leu Asn Pro Pro Ser Gly Asp Glu Arg Gln Arg Lys 
385                 390                 395                 400 


Ile Glu Leu His Val Lys His Met Cys Lys Glu Thr Met Ser Phe Pro 
                405                 410                 415     


Leu Asn Ser Pro Gly Gln Gln Ser Gly Leu Lys Ile Leu Gly Gln Leu 
            420                 425                 430         


Thr Thr Asp Phe Val His His Tyr Ile Val Ala Asn Tyr Phe Ser Glu 
        435                 440                 445             


Leu Phe His Leu Leu Ser Ser Gly Asn Cys Lys Thr Arg Asn Leu Val 
    450                 455                 460                 


Leu Lys Leu Leu Leu Asn Met Ser Glu Asn Pro Thr Ala Ala Arg Asp 
465                 470                 475                 480 


Met Ile Asn Met Lys Ala Leu Ala Ala Leu Lys Leu Ile Phe Asn Gln 
                485                 490                 495     


Lys Glu Ala Lys Ala Asn Leu Val Ser Gly Val Ala Ile Phe Ile Asn 
            500                 505                 510         


Ile Lys Glu His Ile Arg Lys Gly Ser Ile Val Val Val Asp His Leu 
        515                 520                 525             


Ser Tyr Asn Thr Leu Met Ala Ile Phe Arg Glu Val Lys Glu Ile Ile 
    530                 535                 540                 


Glu Thr Met 
545         


<210>  1147
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHLHE22__Homo_sapiens__NP_689627

<400>  1147

Met Glu Arg Gly Met His Leu Gly Ala Ala Ala Ala Gly Glu Asp Asp 
1               5                   10                  15      


Leu Phe Leu His Lys Ser Leu Ser Ala Ser Thr Ser Lys Arg Leu Glu 
            20                  25                  30          


Ala Ala Phe Arg Ser Thr Pro Pro Gly Met Asp Leu Ser Leu Ala Pro 
        35                  40                  45              


Pro Pro Arg Glu Arg Pro Ala Ser Ser Ser Ser Ser Pro Leu Gly Cys 
    50                  55                  60                  


Phe Glu Pro Ala Asp Pro Glu Gly Ala Gly Leu Leu Leu Pro Pro Pro 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Ser Ala Gly Ser Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Val Gly Val Pro Gly Leu Leu Val Gly Ser Ala Gly Val Gly Gly 
            100                 105                 110         


Asp Pro Ser Leu Ser Ser Leu Pro Ala Gly Ala Ala Leu Cys Leu Lys 
        115                 120                 125             


Tyr Gly Glu Ser Ala Ser Arg Gly Ser Val Ala Glu Ser Ser Gly Gly 
    130                 135                 140                 


Glu Gln Ser Pro Asp Asp Asp Ser Asp Gly Arg Cys Glu Leu Val Leu 
145                 150                 155                 160 


Arg Ala Gly Val Ala Asp Pro Arg Ala Ser Pro Gly Ala Gly Gly Gly 
                165                 170                 175     


Gly Ala Lys Ala Ala Glu Gly Cys Ser Asn Ala His Leu His Gly Gly 
            180                 185                 190         


Ala Ser Val Pro Pro Gly Gly Leu Gly Gly Gly Gly Gly Gly Gly Ser 
        195                 200                 205             


Ser Ser Gly Ser Ser Gly Gly Gly Gly Gly Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Lys Lys Ser Lys Glu Gln 
225                 230                 235                 240 


Lys Ala Leu Arg Leu Asn Ile Asn Ala Arg Glu Arg Arg Arg Met His 
                245                 250                 255     


Asp Leu Asn Asp Ala Leu Asp Glu Leu Arg Ala Val Ile Pro Tyr Ala 
            260                 265                 270         


His Ser Pro Ser Val Arg Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu 
        275                 280                 285             


Ala Lys Asn Tyr Ile Leu Met Gln Ala Gln Ala Leu Glu Glu Met Arg 
    290                 295                 300                 


Arg Leu Val Ala Tyr Leu Asn Gln Gly Gln Ala Ile Ser Ala Ala Ser 
305                 310                 315                 320 


Leu Pro Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu His Pro 
                325                 330                 335     


Ala Leu Gly Ala Tyr Glu Gln Ala Ala Gly Tyr Pro Phe Ser Ala Gly 
            340                 345                 350         


Leu Pro Pro Ala Ala Ser Cys Pro Glu Lys Cys Ala Leu Phe Asn Ser 
        355                 360                 365             


Val Ser Ser Ser Leu Cys Lys Gln Cys Thr Glu Lys Pro 
    370                 375                 380     


<210>  1148
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHLHE23__Homo_sapiens__NP_542173

<400>  1148

Met Ser Ile Arg Pro Pro Gly Glu Pro Pro Ser Pro Gly Gly Ala Ala 
1               5                   10                  15      


Met Ala Glu Leu Lys Ser Leu Ser Gly Asp Ala Tyr Leu Ala Leu Ser 
            20                  25                  30          


His Gly Tyr Ala Ala Ala Ala Ala Gly Leu Ala Tyr Gly Ala Ala Arg 
        35                  40                  45              


Glu Pro Glu Ala Ala Arg Gly Tyr Gly Thr Pro Gly Pro Gly Gly Asp 
    50                  55                  60                  


Leu Pro Ala Ala Pro Ala Pro Arg Ala Pro Ala Gln Ala Ala Glu Ser 
65                  70                  75                  80  


Ser Gly Glu Gln Ser Gly Asp Glu Asp Asp Ala Phe Glu Gln Arg Arg 
                85                  90                  95      


Arg Arg Arg Gly Pro Gly Ser Ala Ala Asp Gly Arg Arg Arg Pro Arg 
            100                 105                 110         


Glu Gln Arg Ser Leu Arg Leu Ser Ile Asn Ala Arg Glu Arg Arg Arg 
        115                 120                 125             


Met His Asp Leu Asn Asp Ala Leu Asp Gly Leu Arg Ala Val Ile Pro 
    130                 135                 140                 


Tyr Ala His Ser Pro Ser Val Arg Lys Leu Ser Lys Ile Ala Thr Leu 
145                 150                 155                 160 


Leu Leu Ala Lys Asn Tyr Ile Leu Met Gln Ala Gln Ala Leu Asp Glu 
                165                 170                 175     


Met Arg Arg Leu Val Ala Phe Leu Asn Gln Gly Gln Gly Leu Ala Ala 
            180                 185                 190         


Pro Val Asn Ala Ala Pro Leu Thr Pro Phe Gly Gln Ala Thr Val Cys 
        195                 200                 205             


Pro Phe Ser Ala Gly Ala Ala Leu Gly Pro Cys Pro Asp Lys Cys Ala 
    210                 215                 220                 


Ala Phe Ser Gly Thr Pro Ser Ala Leu Cys Lys His Cys His Glu Lys 
225                 230                 235                 240 


Pro 
    


<210>  1149
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHLHE40__Homo_sapiens__NP_003661

<400>  1149

Met Glu Arg Ile Pro Ser Ala Gln Pro Pro Pro Ala Cys Leu Pro Lys 
1               5                   10                  15      


Ala Pro Gly Leu Glu His Gly Asp Leu Pro Gly Met Tyr Pro Ala His 
            20                  25                  30          


Met Tyr Gln Val Tyr Lys Ser Arg Arg Gly Ile Lys Arg Ser Glu Asp 
        35                  40                  45              


Ser Lys Glu Thr Tyr Lys Leu Pro His Arg Leu Ile Glu Lys Lys Arg 
    50                  55                  60                  


Arg Asp Arg Ile Asn Glu Cys Ile Ala Gln Leu Lys Asp Leu Leu Pro 
65                  70                  75                  80  


Glu His Leu Lys Leu Thr Thr Leu Gly His Leu Glu Lys Ala Val Val 
                85                  90                  95      


Leu Glu Leu Thr Leu Lys His Val Lys Ala Leu Thr Asn Leu Ile Asp 
            100                 105                 110         


Gln Gln Gln Gln Lys Ile Ile Ala Leu Gln Ser Gly Leu Gln Ala Gly 
        115                 120                 125             


Glu Leu Ser Gly Arg Asn Val Glu Thr Gly Gln Glu Met Phe Cys Ser 
    130                 135                 140                 


Gly Phe Gln Thr Cys Ala Arg Glu Val Leu Gln Tyr Leu Ala Lys His 
145                 150                 155                 160 


Glu Asn Thr Arg Asp Leu Lys Ser Ser Gln Leu Val Thr His Leu His 
                165                 170                 175     


Arg Val Val Ser Glu Leu Leu Gln Gly Gly Thr Ser Arg Lys Pro Ser 
            180                 185                 190         


Asp Pro Ala Pro Lys Val Met Asp Phe Lys Glu Lys Pro Ser Ser Pro 
        195                 200                 205             


Ala Lys Gly Ser Glu Gly Pro Gly Lys Asn Cys Val Pro Val Ile Gln 
    210                 215                 220                 


Arg Thr Phe Ala His Ser Ser Gly Glu Gln Ser Gly Ser Asp Thr Asp 
225                 230                 235                 240 


Thr Asp Ser Gly Tyr Gly Gly Glu Ser Glu Lys Gly Asp Leu Arg Ser 
                245                 250                 255     


Glu Gln Pro Cys Phe Lys Ser Asp His Gly Arg Arg Phe Thr Met Gly 
            260                 265                 270         


Glu Arg Ile Gly Ala Ile Lys Gln Glu Ser Glu Glu Pro Pro Thr Lys 
        275                 280                 285             


Lys Asn Arg Met Gln Leu Ser Asp Asp Glu Gly His Phe Thr Ser Ser 
    290                 295                 300                 


Asp Leu Ile Ser Ser Pro Phe Leu Gly Pro His Pro His Gln Pro Pro 
305                 310                 315                 320 


Phe Cys Leu Pro Phe Tyr Leu Ile Pro Pro Ser Ala Thr Ala Tyr Leu 
                325                 330                 335     


Pro Met Leu Glu Lys Cys Trp Tyr Pro Thr Ser Val Pro Val Leu Tyr 
            340                 345                 350         


Pro Gly Leu Asn Ala Ser Ala Ala Ala Leu Ser Ser Phe Met Asn Pro 
        355                 360                 365             


Asp Lys Ile Ser Ala Pro Leu Leu Met Pro Gln Arg Leu Pro Ser Pro 
    370                 375                 380                 


Leu Pro Ala His Pro Ser Val Asp Ser Ser Val Leu Leu Gln Ala Leu 
385                 390                 395                 400 


Lys Pro Ile Pro Pro Leu Asn Leu Glu Thr Lys Asp 
                405                 410         


<210>  1150
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHLHE41__Homo_sapiens__NP_110389

<400>  1150

Met Asp Glu Gly Ile Pro His Leu Gln Glu Arg Gln Leu Leu Glu His 
1               5                   10                  15      


Arg Asp Phe Ile Gly Leu Asp Tyr Ser Ser Leu Tyr Met Cys Lys Pro 
            20                  25                  30          


Lys Arg Ser Met Lys Arg Asp Asp Thr Lys Asp Thr Tyr Lys Leu Pro 
        35                  40                  45              


His Arg Leu Ile Glu Lys Lys Arg Arg Asp Arg Ile Asn Glu Cys Ile 
    50                  55                  60                  


Ala Gln Leu Lys Asp Leu Leu Pro Glu His Leu Lys Leu Thr Thr Leu 
65                  70                  75                  80  


Gly His Leu Glu Lys Ala Val Val Leu Glu Leu Thr Leu Lys His Leu 
                85                  90                  95      


Lys Ala Leu Thr Ala Leu Thr Glu Gln Gln His Gln Lys Ile Ile Ala 
            100                 105                 110         


Leu Gln Asn Gly Glu Arg Ser Leu Lys Ser Pro Ile Gln Ser Asp Leu 
        115                 120                 125             


Asp Ala Phe His Ser Gly Phe Gln Thr Cys Ala Lys Glu Val Leu Gln 
    130                 135                 140                 


Tyr Leu Ser Arg Phe Glu Ser Trp Thr Pro Arg Glu Pro Arg Cys Val 
145                 150                 155                 160 


Gln Leu Ile Asn His Leu His Ala Val Ala Thr Gln Phe Leu Pro Thr 
                165                 170                 175     


Pro Gln Leu Leu Thr Gln Gln Val Pro Leu Ser Lys Gly Thr Gly Ala 
            180                 185                 190         


Pro Ser Ala Ala Gly Ser Ala Ala Ala Pro Cys Leu Glu Arg Ala Gly 
        195                 200                 205             


Gln Lys Leu Glu Pro Leu Ala Tyr Cys Val Pro Val Ile Gln Arg Thr 
    210                 215                 220                 


Gln Pro Ser Ala Glu Leu Ala Ala Glu Asn Asp Thr Asp Thr Asp Ser 
225                 230                 235                 240 


Gly Tyr Gly Gly Glu Ala Glu Ala Arg Pro Asp Arg Glu Lys Gly Lys 
                245                 250                 255     


Gly Ala Gly Ala Ser Arg Val Thr Ile Lys Gln Glu Pro Pro Gly Glu 
            260                 265                 270         


Asp Ser Pro Ala Pro Lys Arg Met Lys Leu Asp Ser Arg Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Leu 
    290                 295                 300                 


Leu Gly Pro Asp Pro Ala Ala Ala Ala Ala Leu Leu Arg Pro Asp Ala 
305                 310                 315                 320 


Ala Leu Leu Ser Ser Leu Val Ala Phe Gly Gly Gly Gly Gly Ala Pro 
                325                 330                 335     


Phe Pro Gln Pro Ala Ala Ala Ala Ala Pro Phe Cys Leu Pro Phe Cys 
            340                 345                 350         


Phe Leu Ser Pro Ser Ala Ala Ala Ala Tyr Val Gln Pro Phe Leu Asp 
        355                 360                 365             


Lys Ser Gly Leu Glu Lys Tyr Leu Tyr Pro Ala Ala Ala Ala Ala Pro 
    370                 375                 380                 


Phe Pro Leu Leu Tyr Pro Gly Ile Pro Ala Pro Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Cys Leu Ser 
                405                 410                 415     


Ser Val Leu Ser Pro Pro Pro Glu Lys Ala Gly Ala Ala Ala Ala Thr 
            420                 425                 430         


Leu Leu Pro His Glu Val Ala Pro Leu Gly Ala Pro His Pro Gln His 
        435                 440                 445             


Pro His Gly Arg Thr His Leu Pro Phe Ala Gly Pro Arg Glu Pro Gly 
    450                 455                 460                 


Asn Pro Glu Ser Ser Ala Gln Glu Asp Pro Ser Gln Pro Gly Lys Glu 
465                 470                 475                 480 


Ala Pro 
        


<210>  1151
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHMT2__Homo_sapiens__NP_001171476

<400>  1151

Met Ala Pro Ala Gly Arg Pro Gly Ala Lys Lys Gly Ile Leu Glu Arg 
1               5                   10                  15      


Leu Glu Ser Gly Glu Val Val Ile Gly Asp Gly Ser Phe Leu Ile Thr 
            20                  25                  30          


Leu Glu Lys Arg Gly Tyr Val Lys Ala Gly Leu Trp Thr Pro Glu Ala 
        35                  40                  45              


Val Ile Glu His Pro Asp Ala Val Arg Gln Leu His Met Glu Phe Leu 
    50                  55                  60                  


Arg Ala Gly Ser Asn Val Met Gln Thr Phe Thr Phe Ser Ala Ser Glu 
65                  70                  75                  80  


Asp Asn Met Glu Ser Lys Tyr Phe Glu His Val Glu Glu Ala Val Trp 
                85                  90                  95      


Ala Val Glu Val Leu Lys Glu Ser Asp Arg Pro Val Ala Val Thr Met 
            100                 105                 110         


Cys Ile Gly Pro Glu Gly Asp Met His Asp Ile Thr Pro Gly Glu Cys 
        115                 120                 125             


Ala Val Arg Leu Val Lys Ala Gly Ala Ser Ile Val Gly Val Asn Cys 
    130                 135                 140                 


Arg Phe Gly Pro Asp Thr Ser Leu Lys Thr Met Glu Leu Met Lys Glu 
145                 150                 155                 160 


Gly Leu Glu Trp Ala Gly Leu Lys Ala His Leu Met Val Gln Pro Leu 
                165                 170                 175     


Gly Phe His Ala Pro Asp Cys Gly Lys Glu Gly Phe Val Asp Leu Pro 
            180                 185                 190         


Glu Tyr Pro Phe Gly Leu Glu Ser Arg Val Ala Thr Arg Trp Asp Ile 
        195                 200                 205             


Gln Lys Tyr Ala Arg Glu Ala Tyr Asn Leu Gly Val Arg Tyr Ile Gly 
    210                 215                 220                 


Gly Cys Cys Gly Phe Glu Pro Tyr His Ile Arg Ala Ile Ala Glu Glu 
225                 230                 235                 240 


Leu Ala Pro Glu Arg Gly Phe Leu Pro Pro Ala Ser Glu Lys His Gly 
                245                 250                 255     


Ser Trp Gly Ser Gly Leu Asp Met His Thr Lys Pro Trp Ile Arg Ala 
            260                 265                 270         


Arg Ala Arg Arg Glu Tyr Trp Glu Asn Leu Leu Pro Ala Ser Gly Arg 
        275                 280                 285             


Pro Phe Cys Pro Ser Leu Ser Lys Pro Asp Phe 
    290                 295                 


<210>  1152
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHMT__Homo_sapiens__NP_001704

<400>  1152

Met Pro Pro Val Gly Gly Lys Lys Ala Lys Lys Gly Ile Leu Glu Arg 
1               5                   10                  15      


Leu Asn Ala Gly Glu Ile Val Ile Gly Asp Gly Gly Phe Val Phe Ala 
            20                  25                  30          


Leu Glu Lys Arg Gly Tyr Val Lys Ala Gly Pro Trp Thr Pro Glu Ala 
        35                  40                  45              


Ala Val Glu His Pro Glu Ala Val Arg Gln Leu His Arg Glu Phe Leu 
    50                  55                  60                  


Arg Ala Gly Ser Asn Val Met Gln Thr Phe Thr Phe Tyr Ala Ser Glu 
65                  70                  75                  80  


Asp Lys Leu Glu Asn Arg Gly Asn Tyr Val Leu Glu Lys Ile Ser Gly 
                85                  90                  95      


Gln Glu Val Asn Glu Ala Ala Cys Asp Ile Ala Arg Gln Val Ala Asp 
            100                 105                 110         


Glu Gly Asp Ala Leu Val Ala Gly Gly Val Ser Gln Thr Pro Ser Tyr 
        115                 120                 125             


Leu Ser Cys Lys Ser Glu Thr Glu Val Lys Lys Val Phe Leu Gln Gln 
    130                 135                 140                 


Leu Glu Val Phe Met Lys Lys Asn Val Asp Phe Leu Ile Ala Glu Tyr 
145                 150                 155                 160 


Phe Glu His Val Glu Glu Ala Val Trp Ala Val Glu Thr Leu Ile Ala 
                165                 170                 175     


Ser Gly Lys Pro Val Ala Ala Thr Met Cys Ile Gly Pro Glu Gly Asp 
            180                 185                 190         


Leu His Gly Val Pro Pro Gly Glu Cys Ala Val Arg Leu Val Lys Ala 
        195                 200                 205             


Gly Ala Ser Ile Ile Gly Val Asn Cys His Phe Asp Pro Thr Ile Ser 
    210                 215                 220                 


Leu Lys Thr Val Lys Leu Met Lys Glu Gly Leu Glu Ala Ala Arg Leu 
225                 230                 235                 240 


Lys Ala His Leu Met Ser Gln Pro Leu Ala Tyr His Thr Pro Asp Cys 
                245                 250                 255     


Asn Lys Gln Gly Phe Ile Asp Leu Pro Glu Phe Pro Phe Gly Leu Glu 
            260                 265                 270         


Pro Arg Val Ala Thr Arg Trp Asp Ile Gln Lys Tyr Ala Arg Glu Ala 
        275                 280                 285             


Tyr Asn Leu Gly Val Arg Tyr Ile Gly Gly Cys Cys Gly Phe Glu Pro 
    290                 295                 300                 


Tyr His Ile Arg Ala Ile Ala Glu Glu Leu Ala Pro Glu Arg Gly Phe 
305                 310                 315                 320 


Leu Pro Pro Ala Ser Glu Lys His Gly Ser Trp Gly Ser Gly Leu Asp 
                325                 330                 335     


Met His Thr Lys Pro Trp Val Arg Ala Arg Ala Arg Lys Glu Tyr Trp 
            340                 345                 350         


Glu Asn Leu Arg Ile Ala Ser Gly Arg Pro Tyr Asn Pro Ser Met Ser 
        355                 360                 365             


Lys Pro Asp Gly Trp Gly Val Thr Lys Gly Thr Ala Glu Leu Met Gln 
    370                 375                 380                 


Gln Lys Glu Ala Thr Thr Glu Gln Gln Leu Lys Glu Leu Phe Glu Lys 
385                 390                 395                 400 


Gln Lys Phe Lys Ser Gln 
                405     


<210>  1153
<211>  974
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BICC1__Homo_sapiens__NP_001073981

<400>  1153

Met Ala Ala Gln Gly Glu Pro Gly Tyr Leu Ala Ala Gln Ser Asp Pro 
1               5                   10                  15      


Gly Ser Asn Ser Glu Arg Ser Thr Asp Ser Pro Val Pro Gly Ser Glu 
            20                  25                  30          


Asp Asp Leu Val Ala Gly Ala Thr Leu His Ser Pro Glu Trp Ser Glu 
        35                  40                  45              


Glu Arg Phe Arg Val Asp Arg Lys Lys Leu Glu Ala Met Leu Gln Ala 
    50                  55                  60                  


Ala Ala Glu Gly Lys Gly Arg Ser Gly Glu Asp Phe Phe Gln Lys Ile 
65                  70                  75                  80  


Met Glu Glu Thr Asn Thr Gln Ile Ala Trp Pro Ser Lys Leu Lys Ile 
                85                  90                  95      


Gly Ala Lys Ser Lys Lys Asp Pro His Ile Lys Val Ser Gly Lys Lys 
            100                 105                 110         


Glu Asp Val Lys Glu Ala Lys Glu Met Ile Met Ser Val Leu Asp Thr 
        115                 120                 125             


Lys Ser Asn Arg Val Thr Leu Lys Met Asp Val Ser His Thr Glu His 
    130                 135                 140                 


Ser His Val Ile Gly Lys Gly Gly Asn Asn Ile Lys Lys Val Met Glu 
145                 150                 155                 160 


Glu Thr Gly Cys His Ile His Phe Pro Asp Ser Asn Arg Asn Asn Gln 
                165                 170                 175     


Ala Glu Lys Ser Asn Gln Val Ser Ile Ala Gly Gln Pro Ala Gly Val 
            180                 185                 190         


Glu Ser Ala Arg Val Arg Ile Arg Glu Leu Leu Pro Leu Val Leu Met 
        195                 200                 205             


Phe Glu Leu Pro Ile Ala Gly Ile Leu Gln Pro Val Pro Asp Pro Asn 
    210                 215                 220                 


Ser Pro Ser Ile Gln His Ile Ser Gln Thr Tyr Asn Ile Ser Val Ser 
225                 230                 235                 240 


Phe Lys Gln Arg Ser Arg Met Tyr Gly Ala Thr Val Ile Val Arg Gly 
                245                 250                 255     


Ser Gln Asn Asn Thr Ser Ala Val Lys Glu Gly Thr Ala Met Leu Leu 
            260                 265                 270         


Glu His Leu Ala Gly Ser Leu Ala Ser Ala Ile Pro Val Ser Thr Gln 
        275                 280                 285             


Leu Asp Ile Ala Ala Gln His His Leu Phe Met Met Gly Arg Asn Gly 
    290                 295                 300                 


Ser Asn Ile Lys His Ile Met Gln Arg Thr Gly Ala Gln Ile His Phe 
305                 310                 315                 320 


Pro Asp Pro Ser Asn Pro Gln Lys Lys Ser Thr Val Tyr Leu Gln Gly 
                325                 330                 335     


Thr Ile Glu Ser Val Cys Leu Ala Arg Gln Tyr Leu Met Gly Cys Leu 
            340                 345                 350         


Pro Leu Val Leu Met Phe Asp Met Lys Glu Glu Ile Glu Val Asp Pro 
        355                 360                 365             


Gln Phe Ile Ala Gln Leu Met Glu Gln Leu Asp Val Phe Ile Ser Ile 
    370                 375                 380                 


Lys Pro Lys Pro Lys Gln Pro Ser Lys Ser Val Ile Val Lys Ser Val 
385                 390                 395                 400 


Glu Arg Asn Ala Leu Asn Met Tyr Glu Ala Arg Lys Cys Leu Leu Gly 
                405                 410                 415     


Leu Glu Ser Ser Gly Val Thr Ile Ala Thr Ser Pro Ser Pro Ala Ser 
            420                 425                 430         


Cys Pro Ala Gly Leu Ala Cys Pro Ser Leu Asp Ile Leu Ala Ser Ala 
        435                 440                 445             


Gly Leu Gly Leu Thr Gly Leu Gly Leu Leu Gly Pro Thr Thr Leu Ser 
    450                 455                 460                 


Leu Asn Thr Ser Thr Thr Pro Asn Ser Leu Leu Asn Ala Leu Asn Ser 
465                 470                 475                 480 


Ser Val Ser Pro Leu Gln Ser Pro Ser Ser Gly Thr Pro Ser Pro Thr 
                485                 490                 495     


Leu Trp Ala Pro Pro Leu Ala Asn Thr Ser Ser Ala Thr Gly Phe Ser 
            500                 505                 510         


Ala Ile Pro His Leu Met Ile Pro Ser Thr Ala Gln Ala Thr Leu Thr 
        515                 520                 525             


Asn Ile Leu Leu Ser Gly Val Pro Thr Tyr Gly His Thr Ala Pro Ser 
    530                 535                 540                 


Pro Pro Pro Gly Leu Thr Pro Val Asp Val His Ile Asn Ser Met Gln 
545                 550                 555                 560 


Thr Glu Gly Lys Lys Ile Ser Ala Ala Leu Asn Gly His Ala Gln Ser 
                565                 570                 575     


Pro Asp Ile Lys Tyr Gly Ala Ile Ser Thr Ser Ser Leu Gly Glu Lys 
            580                 585                 590         


Val Leu Ser Ala Asn His Gly Asp Pro Ser Ile Gln Thr Ser Gly Ser 
        595                 600                 605             


Glu Gln Thr Ser Pro Lys Ser Ser Pro Thr Glu Gly Cys Asn Asp Ala 
    610                 615                 620                 


Phe Val Glu Val Gly Met Pro Arg Ser Pro Ser His Ser Gly Asn Ala 
625                 630                 635                 640 


Gly Asp Leu Lys Gln Met Met Cys Pro Ser Lys Val Ser Cys Ala Lys 
                645                 650                 655     


Arg Gln Thr Val Glu Leu Leu Gln Gly Thr Lys Asn Ser His Leu His 
            660                 665                 670         


Ser Thr Asp Arg Leu Leu Ser Asp Pro Glu Leu Ser Ala Thr Glu Ser 
        675                 680                 685             


Pro Leu Ala Asp Lys Lys Ala Pro Gly Ser Glu Arg Ala Ala Glu Arg 
    690                 695                 700                 


Ala Ala Ala Ala Gln Gln Asn Ser Glu Arg Ala His Leu Ala Pro Arg 
705                 710                 715                 720 


Ser Ser Tyr Val Asn Met Gln Ala Phe Asp Tyr Glu Gln Lys Lys Leu 
                725                 730                 735     


Leu Ala Thr Lys Ala Met Leu Lys Lys Pro Val Val Thr Glu Val Arg 
            740                 745                 750         


Thr Pro Thr Asn Thr Trp Ser Gly Leu Gly Phe Ser Lys Ser Met Pro 
        755                 760                 765             


Ala Glu Thr Ile Lys Glu Leu Arg Arg Ala Asn His Val Ser Tyr Lys 
    770                 775                 780                 


Pro Thr Met Thr Thr Thr Tyr Glu Gly Ser Ser Met Ser Leu Ser Arg 
785                 790                 795                 800 


Ser Asn Ser Arg Glu His Leu Gly Gly Gly Ser Glu Ser Asp Asn Trp 
                805                 810                 815     


Arg Asp Arg Asn Gly Ile Gly Pro Gly Ser His Ser Glu Phe Ala Ala 
            820                 825                 830         


Ser Ile Gly Ser Pro Lys Arg Lys Gln Asn Lys Ser Thr Glu His Tyr 
        835                 840                 845             


Leu Ser Ser Ser Asn Tyr Met Asp Cys Ile Ser Ser Leu Thr Gly Ser 
    850                 855                 860                 


Asn Gly Cys Asn Leu Asn Ser Ser Phe Lys Gly Ser Asp Leu Pro Glu 
865                 870                 875                 880 


Leu Phe Ser Lys Leu Gly Leu Gly Lys Tyr Thr Asp Val Phe Gln Gln 
                885                 890                 895     


Gln Glu Ile Asp Leu Gln Thr Phe Leu Thr Leu Thr Asp Gln Asp Leu 
            900                 905                 910         


Lys Glu Leu Gly Ile Thr Thr Phe Gly Ala Arg Arg Lys Met Leu Leu 
        915                 920                 925             


Ala Ile Ser Glu Leu Asn Lys Asn Arg Arg Lys Leu Phe Glu Ser Pro 
    930                 935                 940                 


Asn Ala Arg Thr Ser Phe Leu Glu Gly Gly Ala Ser Gly Arg Leu Pro 
945                 950                 955                 960 


Arg Gln Tyr His Ser Asp Ile Ala Ser Val Ser Gly Arg Trp 
                965                 970                 


<210>  1154
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BICD1__Homo_sapiens__NP_001003398

<400>  1154

Met Ala Ala Glu Glu Val Leu Gln Thr Val Asp His Tyr Lys Thr Glu 
1               5                   10                  15      


Ile Glu Arg Leu Thr Lys Glu Leu Thr Glu Thr Thr His Glu Lys Ile 
            20                  25                  30          


Gln Ala Ala Glu Tyr Gly Leu Val Val Leu Glu Glu Lys Leu Thr Leu 
        35                  40                  45              


Lys Gln Gln Tyr Asp Glu Leu Glu Ala Glu Tyr Asp Ser Leu Lys Gln 
    50                  55                  60                  


Glu Leu Glu Gln Leu Lys Glu Ala Phe Gly Gln Ser Phe Ser Ile His 
65                  70                  75                  80  


Arg Lys Val Ala Glu Asp Gly Glu Thr Arg Glu Glu Thr Leu Leu Gln 
                85                  90                  95      


Glu Ser Ala Ser Lys Glu Ala Tyr Tyr Leu Gly Lys Ile Leu Glu Met 
            100                 105                 110         


Gln Asn Glu Leu Lys Gln Ser Arg Ala Val Val Thr Asn Val Gln Ala 
        115                 120                 125             


Glu Asn Glu Arg Leu Thr Ala Val Val Gln Asp Leu Lys Glu Asn Asn 
    130                 135                 140                 


Glu Met Val Glu Leu Gln Arg Ile Arg Met Lys Asp Glu Ile Arg Glu 
145                 150                 155                 160 


Tyr Lys Phe Arg Glu Ala Arg Leu Leu Gln Asp Tyr Thr Glu Leu Glu 
                165                 170                 175     


Glu Glu Asn Ile Thr Leu Gln Lys Leu Val Ser Thr Leu Lys Gln Asn 
            180                 185                 190         


Gln Val Glu Tyr Glu Gly Leu Lys His Glu Ile Lys Arg Phe Glu Glu 
        195                 200                 205             


Glu Thr Val Leu Leu Asn Ser Gln Leu Glu Asp Ala Ile Arg Leu Lys 
    210                 215                 220                 


Glu Ile Ala Glu His Gln Leu Glu Glu Ala Leu Glu Thr Leu Lys Asn 
225                 230                 235                 240 


Glu Arg Glu Gln Lys Asn Asn Leu Arg Lys Glu Leu Ser Gln Tyr Ile 
                245                 250                 255     


Ser Leu Asn Asp Asn His Ile Ser Ile Ser Val Asp Gly Leu Lys Phe 
            260                 265                 270         


Ala Glu Asp Gly Ser Glu Pro Asn Asn Asp Asp Lys Met Asn Gly His 
        275                 280                 285             


Ile His Gly Pro Leu Val Lys Leu Asn Gly Asp Tyr Arg Thr Pro Thr 
    290                 295                 300                 


Leu Arg Lys Gly Glu Ser Leu Asn Pro Val Ser Asp Leu Phe Ser Glu 
305                 310                 315                 320 


Leu Asn Ile Ser Glu Ile Gln Lys Leu Lys Gln Gln Leu Met Gln Val 
                325                 330                 335     


Glu Arg Glu Lys Ala Ile Leu Leu Ala Asn Leu Gln Glu Ser Gln Thr 
            340                 345                 350         


Gln Leu Glu His Thr Lys Gly Ala Leu Thr Glu Gln His Glu Arg Val 
        355                 360                 365             


His Arg Leu Thr Glu His Val Asn Ala Met Arg Gly Leu Gln Ser Ser 
    370                 375                 380                 


Lys Glu Leu Lys Ala Glu Leu Asp Gly Glu Lys Gly Arg Asp Ser Gly 
385                 390                 395                 400 


Glu Glu Ala His Asp Tyr Glu Val Asp Ile Asn Gly Leu Glu Ile Leu 
                405                 410                 415     


Glu Cys Lys Tyr Arg Val Ala Val Thr Glu Val Ile Asp Leu Lys Ala 
            420                 425                 430         


Glu Ile Lys Ala Leu Lys Glu Lys Tyr Asn Lys Ser Val Glu Asn Tyr 
        435                 440                 445             


Thr Asp Glu Lys Ala Lys Tyr Glu Ser Lys Ile Gln Met Tyr Asp Glu 
    450                 455                 460                 


Gln Val Thr Ser Leu Glu Lys Thr Thr Lys Glu Ser Gly Glu Lys Met 
465                 470                 475                 480 


Ala His Met Glu Lys Glu Leu Gln Lys Met Thr Ser Ile Ala Asn Glu 
                485                 490                 495     


Asn His Ser Thr Leu Asn Thr Ala Gln Asp Glu Leu Val Thr Phe Ser 
            500                 505                 510         


Glu Glu Leu Ala Gln Leu Tyr His His Val Cys Leu Cys Asn Asn Glu 
        515                 520                 525             


Thr Pro Asn Arg Val Met Leu Asp Tyr Tyr Arg Gln Ser Arg Val Thr 
    530                 535                 540                 


Arg Ser Gly Ser Leu Lys Gly Pro Asp Asp Pro Arg Gly Leu Leu Ser 
545                 550                 555                 560 


Pro Arg Leu Ala Arg Arg Gly Val Ser Ser Pro Val Glu Thr Arg Thr 
                565                 570                 575     


Ser Ser Glu Pro Val Ala Lys Glu Ser Thr Glu Ala Ser Lys Glu Pro 
            580                 585                 590         


Ser Pro Thr Lys Thr Pro Thr Ile Ser Pro Val Ile Thr Ala Pro Pro 
        595                 600                 605             


Ser Ser Pro Val Leu Asp Thr Ser Asp Ile Arg Lys Glu Pro Met Asn 
    610                 615                 620                 


Ile Tyr Asn Leu Asn Ala Ile Ile Arg Asp Gln Ile Lys His Leu Gln 
625                 630                 635                 640 


Lys Ala Val Asp Arg Ser Leu Gln Leu Ser Arg Gln Arg Ala Ala Ala 
                645                 650                 655     


Arg Glu Leu Ala Pro Met Ile Asp Lys Asp Lys Glu Ala Leu Met Glu 
            660                 665                 670         


Glu Ile Leu Lys Leu Lys Ser Leu Leu Ser Thr Lys Arg Glu Gln Ile 
        675                 680                 685             


Ala Thr Leu Arg Ala Val Leu Lys Ala Asn Lys Gln Thr Ala Glu Val 
    690                 695                 700                 


Ala Leu Ala Asn Leu Lys Asn Lys Tyr Glu Asn Glu Lys Ala Met Val 
705                 710                 715                 720 


Thr Glu Thr Met Thr Lys Leu Arg Asn Glu Leu Lys Ala Leu Lys Glu 
                725                 730                 735     


Asp Ala Ala Thr Phe Ser Ser Leu Arg Ala Met Phe Ala Thr Arg Cys 
            740                 745                 750         


Asp Glu Tyr Val Thr Gln Leu Asp Glu Met Gln Arg Gln Leu Ala Ala 
        755                 760                 765             


Ala Glu Asp Glu Lys Lys Thr Leu Asn Thr Leu Leu Arg Met Ala Ile 
    770                 775                 780                 


Gln Gln Lys Leu Ala Leu Thr Gln Arg Leu Glu Asp Leu Glu Phe Asp 
785                 790                 795                 800 


His Glu Gln Ser Arg Arg Ser Lys Gly Lys Leu Gly Lys Ser Lys Ile 
                805                 810                 815     


Gly Ser Pro Lys Ile Val Ser Ser Leu Leu Pro Pro Tyr Arg His Ser 
            820                 825                 830         


Ala His Asn 
        835 


<210>  1155
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BICD2__Homo_sapiens__NP_001003800

<400>  1155

Met Ser Ala Pro Ser Glu Glu Glu Glu Tyr Ala Arg Leu Val Met Glu 
1               5                   10                  15      


Ala Gln Pro Glu Trp Leu Arg Ala Glu Val Lys Arg Leu Ser His Glu 
            20                  25                  30          


Leu Ala Glu Thr Thr Arg Glu Lys Ile Gln Ala Ala Glu Tyr Gly Leu 
        35                  40                  45              


Ala Val Leu Glu Glu Lys His Gln Leu Lys Leu Gln Phe Glu Glu Leu 
    50                  55                  60                  


Glu Val Asp Tyr Glu Ala Ile Arg Ser Glu Met Glu Gln Leu Lys Glu 
65                  70                  75                  80  


Ala Phe Gly Gln Ala His Thr Asn His Lys Lys Val Ala Ala Asp Gly 
                85                  90                  95      


Glu Ser Arg Glu Glu Ser Leu Ile Gln Glu Ser Ala Ser Lys Glu Gln 
            100                 105                 110         


Tyr Tyr Val Arg Lys Val Leu Glu Leu Gln Thr Glu Leu Lys Gln Leu 
        115                 120                 125             


Arg Asn Val Leu Thr Asn Thr Gln Ser Glu Asn Glu Arg Leu Ala Ser 
    130                 135                 140                 


Val Ala Gln Glu Leu Lys Glu Ile Asn Gln Asn Val Glu Ile Gln Arg 
145                 150                 155                 160 


Gly Arg Leu Arg Asp Asp Ile Lys Glu Tyr Lys Phe Arg Glu Ala Arg 
                165                 170                 175     


Leu Leu Gln Asp Tyr Ser Glu Leu Glu Glu Glu Asn Ile Ser Leu Gln 
            180                 185                 190         


Lys Gln Val Ser Val Leu Arg Gln Asn Gln Val Glu Phe Glu Gly Leu 
        195                 200                 205             


Lys His Glu Ile Lys Arg Leu Glu Glu Glu Thr Glu Tyr Leu Asn Ser 
    210                 215                 220                 


Gln Leu Glu Asp Ala Ile Arg Leu Lys Glu Ile Ser Glu Arg Gln Leu 
225                 230                 235                 240 


Glu Glu Ala Leu Glu Thr Leu Lys Thr Glu Arg Glu Gln Lys Asn Ser 
                245                 250                 255     


Leu Arg Lys Glu Leu Ser His Tyr Met Ser Ile Asn Asp Ser Phe Tyr 
            260                 265                 270         


Thr Ser His Leu His Val Ser Leu Asp Gly Leu Lys Phe Ser Asp Asp 
        275                 280                 285             


Ala Ala Glu Pro Asn Asn Asp Ala Glu Ala Leu Val Asn Gly Phe Glu 
    290                 295                 300                 


His Gly Gly Leu Ala Lys Leu Pro Leu Asp Asn Lys Thr Ser Thr Pro 
305                 310                 315                 320 


Lys Lys Glu Gly Leu Ala Pro Pro Ser Pro Ser Leu Val Ser Asp Leu 
                325                 330                 335     


Leu Ser Glu Leu Asn Ile Ser Glu Ile Gln Lys Leu Lys Gln Gln Leu 
            340                 345                 350         


Met Gln Met Glu Arg Glu Lys Ala Gly Leu Leu Ala Thr Leu Gln Asp 
        355                 360                 365             


Thr Gln Lys Gln Leu Glu His Thr Arg Gly Ser Leu Ser Glu Gln Gln 
    370                 375                 380                 


Glu Lys Val Thr Arg Leu Thr Glu Asn Leu Ser Ala Leu Arg Arg Leu 
385                 390                 395                 400 


Gln Ala Ser Lys Glu Arg Gln Thr Ala Leu Asp Asn Glu Lys Asp Arg 
                405                 410                 415     


Asp Ser His Glu Asp Gly Asp Tyr Tyr Glu Val Asp Ile Asn Gly Pro 
            420                 425                 430         


Glu Ile Leu Ala Cys Lys Tyr His Val Ala Val Ala Glu Ala Gly Glu 
        435                 440                 445             


Leu Arg Glu Gln Leu Lys Ala Leu Arg Ser Thr His Glu Ala Arg Glu 
    450                 455                 460                 


Ala Gln His Ala Glu Glu Lys Gly Arg Tyr Glu Ala Glu Gly Gln Ala 
465                 470                 475                 480 


Leu Thr Glu Lys Val Ser Leu Leu Glu Lys Ala Ser Arg Gln Asp Arg 
                485                 490                 495     


Glu Leu Leu Ala Arg Leu Glu Lys Glu Leu Lys Lys Val Ser Asp Val 
            500                 505                 510         


Ala Gly Glu Thr Gln Gly Ser Leu Ser Val Ala Gln Asp Glu Leu Val 
        515                 520                 525             


Thr Phe Ser Glu Glu Leu Ala Asn Leu Tyr His His Val Cys Met Cys 
    530                 535                 540                 


Asn Asn Glu Thr Pro Asn Arg Val Met Leu Asp Tyr Tyr Arg Glu Gly 
545                 550                 555                 560 


Gln Gly Gly Ala Gly Arg Thr Ser Pro Gly Gly Arg Thr Ser Pro Glu 
                565                 570                 575     


Ala Arg Gly Arg Arg Ser Pro Ile Leu Leu Pro Lys Gly Leu Leu Ala 
            580                 585                 590         


Pro Glu Ala Gly Arg Ala Asp Gly Gly Thr Gly Asp Ser Ser Pro Ser 
        595                 600                 605             


Pro Gly Ser Ser Leu Pro Ser Pro Leu Ser Asp Pro Arg Arg Glu Pro 
    610                 615                 620                 


Met Asn Ile Tyr Asn Leu Ile Ala Ile Ile Arg Asp Gln Ile Lys His 
625                 630                 635                 640 


Leu Gln Ala Ala Val Asp Arg Thr Thr Glu Leu Ser Arg Gln Arg Ile 
                645                 650                 655     


Ala Ser Gln Glu Leu Gly Pro Ala Val Asp Lys Asp Lys Glu Ala Leu 
            660                 665                 670         


Met Glu Glu Ile Leu Lys Leu Lys Ser Leu Leu Ser Thr Lys Arg Glu 
        675                 680                 685             


Gln Ile Thr Thr Leu Arg Thr Val Leu Lys Ala Asn Lys Gln Thr Ala 
    690                 695                 700                 


Glu Val Ala Leu Ala Asn Leu Lys Ser Lys Tyr Glu Asn Glu Lys Ala 
705                 710                 715                 720 


Met Val Thr Glu Thr Met Met Lys Leu Arg Asn Glu Leu Lys Ala Leu 
                725                 730                 735     


Lys Glu Asp Ala Ala Thr Phe Ser Ser Leu Arg Ala Met Phe Ala Thr 
            740                 745                 750         


Arg Cys Asp Glu Tyr Ile Thr Gln Leu Asp Glu Met Gln Arg Gln Leu 
        755                 760                 765             


Ala Ala Ala Glu Asp Glu Lys Lys Thr Leu Asn Ser Leu Leu Arg Met 
    770                 775                 780                 


Ala Ile Gln Gln Lys Leu Ala Leu Thr Gln Arg Leu Glu Leu Leu Glu 
785                 790                 795                 800 


Leu Asp His Glu Gln Thr Arg Arg Gly Arg Ala Lys Ala Ala Pro Lys 
                805                 810                 815     


Thr Lys Pro Ala Thr Pro Ser Val Ser His Thr Cys Ala Cys Ala Ser 
            820                 825                 830         


Asp Arg Ala Glu Gly Thr Gly Leu Ala Asn Gln Val Phe Cys Ser Glu 
        835                 840                 845             


Lys His Ser Ile Tyr Cys Asp 
    850                 855 


<210>  1156
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BID__Homo_sapiens__NP_001187

<400>  1156

Met Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile 
1               5                   10                  15      


Thr Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser 
            20                  25                  30          


Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala 
        35                  40                  45              


Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser 
    50                  55                  60                  


Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu 
65                  70                  75                  80  


Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser 
                85                  90                  95      


Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln 
            100                 105                 110         


Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala 
        115                 120                 125             


Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys 
    130                 135                 140                 


Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala 
145                 150                 155                 160 


Ser His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn 
                165                 170                 175     


Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn 
            180                 185                 190         


Gly Met Asp 
        195 


<210>  1157
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIN1__Homo_sapiens__NP_004296

<400>  1157

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Ala Glu Glu 
                165                 170                 175     


Glu Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu 
            180                 185                 190         


Gln Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val 
        195                 200                 205             


Asn Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu 
    210                 215                 220                 


Met Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu 
225                 230                 235                 240 


Lys Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Arg Lys 
                245                 250                 255     


Lys Ser Lys Leu Phe Ser Arg Leu Arg Arg Lys Lys Asn Ser Asp Asn 
            260                 265                 270         


Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
        275                 280                 285             


Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
    290                 295                 300                 


Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Pro Ala 
305                 310                 315                 320 


Glu Ala Ser Glu Val Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln 
                325                 330                 335     


Glu Pro Gly Glu Thr Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro 
            340                 345                 350         


Ala Val Val Val Glu Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu 
        355                 360                 365             


Gly Gly Ser Gly Ala Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe 
    370                 375                 380                 


Lys Val Gln Ala Gln His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu 
385                 390                 395                 400 


Gln Leu Lys Ala Gly Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro 
                405                 410                 415     


Glu Glu Gln Asp Glu Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp 
            420                 425                 430         


Asn Gln His Lys Glu Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn 
        435                 440                 445             


Phe Thr Glu Arg Val Pro 
    450                 


<210>  1158
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIN2__Homo_sapiens__NP_001276936

<400>  1158

Met Val Leu Gln Lys Leu Gly Lys Ala Val Glu Thr Lys Asp Glu Arg 
1               5                   10                  15      


Phe Glu Gln Ser Ala Ser Asn Phe Tyr Gln Gln Gln Ala Glu Gly His 
            20                  25                  30          


Lys Leu Tyr Lys Asp Leu Lys Asn Phe Leu Ser Ala Val Lys Val Met 
        35                  40                  45              


His Glu Ser Ser Lys Arg Val Ser Glu Thr Leu Gln Glu Ile Tyr Ser 
    50                  55                  60                  


Ser Glu Trp Asp Gly His Glu Glu Leu Lys Ala Ile Val Trp Asn Asn 
65                  70                  75                  80  


Asp Leu Leu Trp Glu Asp Tyr Glu Glu Lys Leu Ala Asp Gln Ala Val 
                85                  90                  95      


Arg Thr Met Glu Ile Tyr Val Ala Gln Phe Ser Glu Ile Lys Glu Arg 
            100                 105                 110         


Ile Ala Lys Arg Gly Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His 
        115                 120                 125             


His Leu Glu Ala Val Gln Asn Ala Lys Lys Lys Asp Glu Ala Lys Thr 
    130                 135                 140                 


Ala Lys Ala Glu Glu Glu Phe Asn Lys Ala Gln Thr Val Phe Glu Asp 
145                 150                 155                 160 


Leu Asn Gln Glu Leu Leu Glu Glu Leu Pro Ile Leu Tyr Asn Ser Arg 
                165                 170                 175     


Ile Gly Cys Tyr Val Thr Ile Phe Gln Asn Ile Ser Asn Leu Arg Asp 
            180                 185                 190         


Val Phe Tyr Arg Glu Met Ser Lys Leu Asn His Asn Leu Tyr Glu Val 
        195                 200                 205             


Met Ser Lys Leu Glu Lys Gln His Ser Asn Lys Val Phe Val Val Lys 
    210                 215                 220                 


Gly Leu Ser Ser Ser Ser Arg Arg Ser Leu Val Ile Ser Pro Pro Val 
225                 230                 235                 240 


Arg Thr Ala Thr Val Ser Ser Pro Leu Thr Ser Pro Thr Ser Pro Ser 
                245                 250                 255     


Thr Leu Ser Leu Lys Ser Glu Ser Glu Ser Val Ser Ala Thr Glu Asp 
            260                 265                 270         


Leu Ala Pro Asp Ala Ala Gln Gly Glu Asp Asn Ser Glu Ile Lys Glu 
        275                 280                 285             


Leu Leu Glu Glu Glu Glu Ile Glu Lys Glu Gly Ser Glu Ala Ser Ser 
    290                 295                 300                 


Ser Glu Glu Asp Glu Pro Leu Pro Ala Cys Asn Gly Pro Ala Gln Ala 
305                 310                 315                 320 


Gln Pro Ser Pro Thr Thr Glu Arg Ala Lys Ser Gln Glu Glu Val Leu 
                325                 330                 335     


Pro Ser Ser Thr Thr Pro Ser Pro Gly Gly Ala Leu Ser Pro Ser Gly 
            340                 345                 350         


Gln Pro Ser Ser Ser Ala Thr Glu Val Val Leu Arg Thr Arg Thr Ala 
        355                 360                 365             


Ser Glu Gly Ser Glu Gln Pro Lys Lys Arg Ala Ser Ile Gln Arg Thr 
    370                 375                 380                 


Ser Ala Pro Pro Ser Arg Pro Pro Pro Pro Arg Ala Thr Ala Ser Pro 
385                 390                 395                 400 


Arg Pro Ser Ser Gly Asn Ile Pro Ser Ser Pro Thr Ala Ser Gly Gly 
                405                 410                 415     


Gly Ser Pro Thr Ser Pro Arg Ala Ser Leu Gly Thr Gly Thr Ala Ser 
            420                 425                 430         


Pro Arg Thr Ser Leu Glu Val Ser Pro Asn Pro Glu Pro Pro Glu Lys 
        435                 440                 445             


Pro Val Arg Thr Pro Glu Ala Lys Glu Asn Glu Asn Ile His Asn Gln 
    450                 455                 460                 


Asn Pro Glu Glu Leu Cys Thr Ser Pro Thr Leu Met Thr Ser Gln Val 
465                 470                 475                 480 


Ala Ser Glu Pro Gly Glu Ala Lys Lys Met Glu Asp Lys Glu Lys Asp 
                485                 490                 495     


Asn Lys Leu Ile Ser Ala Asn Ser Ser Glu Gly Gln Asp Gln Leu Gln 
            500                 505                 510         


Val Ser Met Val Pro Glu Asn Asn Asn Leu Thr Ala Pro Glu Pro Gln 
        515                 520                 525             


Glu Glu Val Ser Thr Ser Glu Asn Pro Gln Leu 
    530                 535                 


<210>  1159
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIN3__Homo_sapiens__NP_061158

<400>  1159

Met Ser Trp Ile Pro Phe Lys Ile Gly Gln Pro Lys Lys Gln Ile Val 
1               5                   10                  15      


Pro Lys Thr Val Glu Arg Asp Phe Glu Arg Glu Tyr Gly Lys Leu Gln 
            20                  25                  30          


Gln Leu Glu Glu Gln Thr Arg Arg Leu Gln Lys Asp Met Lys Lys Ser 
        35                  40                  45              


Thr Asp Ala Asp Leu Ala Met Ser Lys Ser Ala Val Lys Ile Ser Leu 
    50                  55                  60                  


Asp Leu Leu Ser Asn Pro Leu Cys Glu Gln Asp Gln Asp Leu Leu Asn 
65                  70                  75                  80  


Met Val Thr Ala Leu Asp Thr Ala Met Lys Arg Met Asp Ala Phe Asn 
                85                  90                  95      


Gln Glu Lys Val Asn Gln Ile Gln Lys Thr Val Ile Glu Pro Leu Lys 
            100                 105                 110         


Lys Phe Gly Ser Val Phe Pro Ser Leu Asn Met Ala Val Lys Arg Arg 
        115                 120                 125             


Glu Gln Ala Leu Gln Asp Tyr Arg Arg Leu Gln Ala Lys Val Glu Lys 
    130                 135                 140                 


Tyr Glu Glu Lys Glu Lys Thr Gly Pro Val Leu Ala Lys Leu His Gln 
145                 150                 155                 160 


Ala Arg Glu Glu Leu Arg Pro Val Arg Glu Asp Phe Glu Ala Lys Asn 
                165                 170                 175     


Arg Gln Leu Leu Glu Glu Met Pro Arg Phe Tyr Gly Ser Arg Leu Asp 
            180                 185                 190         


Tyr Phe Gln Pro Ser Phe Glu Ser Leu Ile Arg Ala Gln Val Val Tyr 
        195                 200                 205             


Tyr Ser Glu Met His Lys Ile Phe Gly Asp Leu Ser His Gln Leu Asp 
    210                 215                 220                 


Gln Pro Gly His Ser Asp Glu Gln Arg Glu Arg Glu Asn Glu Ala Lys 
225                 230                 235                 240 


Leu Ser Glu Leu Arg Ala Leu Ser Ile Val Ala Asp Asp 
                245                 250             


<210>  1160
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIRC2__Homo_sapiens__NP_001243092

<400>  1160

Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210>  1161
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIRC3__Homo_sapiens__NP_892007

<400>  1161

Met Asn Ile Val Glu Asn Ser Ile Phe Leu Ser Asn Leu Met Lys Ser 
1               5                   10                  15      


Ala Asn Thr Phe Glu Leu Lys Tyr Asp Leu Ser Cys Glu Leu Tyr Arg 
            20                  25                  30          


Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
        35                  40                  45              


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val 
    50                  55                  60                  


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Thr Glu Lys His Lys Lys Leu Tyr Pro Ser Cys Arg Phe Val 
                85                  90                  95      


Gln Ser Leu Asn Ser Val Asn Asn Leu Glu Ala Thr Ser Gln Pro Thr 
            100                 105                 110         


Phe Pro Ser Ser Val Thr Asn Ser Thr His Ser Leu Leu Pro Gly Thr 
        115                 120                 125             


Glu Asn Ser Gly Tyr Phe Arg Gly Ser Tyr Ser Asn Ser Pro Ser Asn 
    130                 135                 140                 


Pro Val Asn Ser Arg Ala Asn Gln Asp Phe Ser Ala Leu Met Arg Ser 
145                 150                 155                 160 


Ser Tyr His Cys Ala Met Asn Asn Glu Asn Ala Arg Leu Leu Thr Phe 
                165                 170                 175     


Gln Thr Trp Pro Leu Thr Phe Leu Ser Pro Thr Asp Leu Ala Lys Ala 
            180                 185                 190         


Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys 
        195                 200                 205             


Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asn Ala Met Ser Glu 
    210                 215                 220                 


His Leu Arg His Phe Pro Lys Cys Pro Phe Ile Glu Asn Gln Leu Gln 
225                 230                 235                 240 


Asp Thr Ser Arg Tyr Thr Val Ser Asn Leu Ser Met Gln Thr His Ala 
                245                 250                 255     


Ala Arg Phe Lys Thr Phe Phe Asn Trp Pro Ser Ser Val Leu Val Asn 
            260                 265                 270         


Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Asn Ser Asp 
        275                 280                 285             


Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser 
    290                 295                 300                 


Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro Arg Cys Glu 
305                 310                 315                 320 


Tyr Leu Ile Arg Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala 
                325                 330                 335     


Ser Tyr Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Ser Pro 
            340                 345                 350         


Gly Asp Glu Asn Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu 
        355                 360                 365             


Asp His Ser Glu Asp Ala Ile Met Met Asn Thr Pro Val Ile Asn Ala 
    370                 375                 380                 


Ala Val Glu Met Gly Phe Ser Arg Ser Leu Val Lys Gln Thr Val Gln 
385                 390                 395                 400 


Arg Lys Ile Leu Ala Thr Gly Glu Asn Tyr Arg Leu Val Asn Asp Leu 
                405                 410                 415     


Val Leu Asp Leu Leu Asn Ala Glu Asp Glu Ile Arg Glu Glu Glu Arg 
            420                 425                 430         


Glu Arg Ala Thr Glu Glu Lys Glu Ser Asn Asp Leu Leu Leu Ile Arg 
        435                 440                 445             


Lys Asn Arg Met Ala Leu Phe Gln His Leu Thr Cys Val Ile Pro Ile 
    450                 455                 460                 


Leu Asp Ser Leu Leu Thr Ala Gly Ile Ile Asn Glu Gln Glu His Asp 
465                 470                 475                 480 


Val Ile Lys Gln Lys Thr Gln Thr Ser Leu Gln Ala Arg Glu Leu Ile 
                485                 490                 495     


Asp Thr Ile Leu Val Lys Gly Asn Ile Ala Ala Thr Val Phe Arg Asn 
            500                 505                 510         


Ser Leu Gln Glu Ala Glu Ala Val Leu Tyr Glu His Leu Phe Val Gln 
        515                 520                 525             


Gln Asp Ile Lys Tyr Ile Pro Thr Glu Asp Val Ser Asp Leu Pro Val 
    530                 535                 540                 


Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys 
545                 550                 555                 560 


Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys Gly His Leu Val 
                565                 570                 575     


Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg 
            580                 585                 590         


Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
        595                 600                 


<210>  1162
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIRC5__Homo_sapiens__NP_001012270

<400>  1162

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Met Gln Arg Lys Pro Thr Ile 
65                  70                  75                  80  


Arg Arg Lys Asn Leu Arg Lys Leu Arg Arg Lys Cys Ala Val Pro Ser 
                85                  90                  95      


Ser Ser Trp Leu Pro Trp Ile Glu Ala Ser Gly Arg Ser Cys Leu Val 
            100                 105                 110         


Pro Glu Trp Leu His His Phe Gln Gly Leu Phe Pro Gly Ala Thr Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Leu Ala Met Ser 
    130                 135         


<210>  1163
<211>  4857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIRC6__Homo_sapiens__NP_057336

<400>  1163

Met Val Thr Gly Gly Gly Ala Ala Pro Pro Gly Thr Val Thr Glu Pro 
1               5                   10                  15      


Leu Pro Ser Val Ile Val Leu Ser Ala Gly Arg Lys Met Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ser Gly Pro Gly Cys Ser Ser Ala Ala Gly Ala Gly 
        35                  40                  45              


Ala Ala Gly Val Ser Glu Trp Leu Val Leu Arg Asp Gly Cys Met His 
    50                  55                  60                  


Cys Asp Ala Asp Gly Leu His Ser Leu Ser Tyr His Pro Ala Leu Asn 
65                  70                  75                  80  


Ala Ile Leu Ala Val Thr Ser Arg Gly Thr Ile Lys Val Ile Asp Gly 
                85                  90                  95      


Thr Ser Gly Ala Thr Leu Gln Ala Ser Ala Leu Ser Ala Lys Pro Gly 
            100                 105                 110         


Gly Gln Val Lys Cys Gln Tyr Ile Ser Ala Val Asp Lys Val Ile Phe 
        115                 120                 125             


Val Asp Asp Tyr Ala Val Gly Cys Arg Lys Asp Leu Asn Gly Ile Leu 
    130                 135                 140                 


Leu Leu Asp Thr Ala Leu Gln Thr Pro Val Ser Lys Gln Asp Asp Val 
145                 150                 155                 160 


Val Gln Leu Glu Leu Pro Val Thr Glu Ala Gln Gln Leu Leu Ser Ala 
                165                 170                 175     


Cys Leu Glu Lys Val Asp Ile Ser Ser Thr Glu Gly Tyr Asp Leu Phe 
            180                 185                 190         


Ile Thr Gln Leu Lys Asp Gly Leu Lys Asn Thr Ser His Glu Thr Ala 
        195                 200                 205             


Ala Asn His Lys Val Ala Lys Trp Ala Thr Val Thr Phe His Leu Pro 
    210                 215                 220                 


His His Val Leu Lys Ser Ile Ala Ser Ala Ile Val Asn Glu Leu Lys 
225                 230                 235                 240 


Lys Ile Asn Gln Asn Val Ala Ala Leu Pro Val Ala Ser Ser Val Met 
                245                 250                 255     


Asp Arg Leu Ser Tyr Leu Leu Pro Ser Ala Arg Pro Glu Leu Gly Val 
            260                 265                 270         


Gly Pro Gly Arg Ser Val Asp Arg Ser Leu Met Tyr Ser Glu Ala Asn 
        275                 280                 285             


Arg Arg Glu Thr Phe Thr Ser Trp Pro His Val Gly Tyr Arg Trp Ala 
    290                 295                 300                 


Gln Pro Asp Pro Met Ala Gln Ala Gly Phe Tyr His Gln Pro Ala Ser 
305                 310                 315                 320 


Ser Gly Asp Asp Arg Ala Met Cys Phe Thr Cys Ser Val Cys Leu Val 
                325                 330                 335     


Cys Trp Glu Pro Thr Asp Glu Pro Trp Ser Glu His Glu Arg His Ser 
            340                 345                 350         


Pro Asn Cys Pro Phe Val Lys Gly Glu His Thr Gln Asn Val Pro Leu 
        355                 360                 365             


Ser Val Thr Leu Ala Thr Ser Pro Ala Gln Phe Pro Cys Thr Asp Gly 
    370                 375                 380                 


Thr Asp Arg Ile Ser Cys Phe Gly Ser Gly Ser Cys Pro His Phe Leu 
385                 390                 395                 400 


Ala Ala Ala Thr Lys Arg Gly Lys Ile Cys Ile Trp Asp Val Ser Lys 
                405                 410                 415     


Leu Met Lys Val His Leu Lys Phe Glu Ile Asn Ala Tyr Asp Pro Ala 
            420                 425                 430         


Ile Val Gln Gln Leu Ile Leu Ser Gly Asp Pro Ser Ser Gly Val Asp 
        435                 440                 445             


Ser Arg Arg Pro Thr Leu Ala Trp Leu Glu Asp Ser Ser Ser Cys Ser 
    450                 455                 460                 


Asp Ile Pro Lys Leu Glu Gly Asp Ser Asp Asp Leu Leu Glu Asp Ser 
465                 470                 475                 480 


Asp Ser Glu Glu His Ser Arg Ser Asp Ser Val Thr Gly His Thr Ser 
                485                 490                 495     


Gln Lys Glu Ala Met Glu Val Ser Leu Asp Ile Thr Ala Leu Ser Ile 
            500                 505                 510         


Leu Gln Gln Pro Glu Lys Leu Gln Trp Glu Ile Val Ala Asn Val Leu 
        515                 520                 525             


Glu Asp Thr Val Lys Asp Leu Glu Glu Leu Gly Ala Asn Pro Cys Leu 
    530                 535                 540                 


Thr Asn Ser Lys Ser Glu Lys Thr Lys Glu Lys His Gln Glu Gln His 
545                 550                 555                 560 


Asn Ile Pro Phe Pro Cys Leu Leu Ala Gly Gly Leu Leu Thr Tyr Lys 
                565                 570                 575     


Ser Pro Ala Thr Ser Pro Ile Ser Ser Asn Ser His Arg Ser Leu Asp 
            580                 585                 590         


Gly Leu Ser Arg Thr Gln Gly Glu Ser Ile Ser Glu Gln Gly Ser Thr 
        595                 600                 605             


Asp Asn Glu Ser Cys Thr Asn Ser Glu Leu Asn Ser Pro Leu Val Arg 
    610                 615                 620                 


Arg Thr Leu Pro Val Leu Leu Leu Tyr Ser Ile Lys Glu Ser Asp Glu 
625                 630                 635                 640 


Lys Ala Gly Lys Ile Phe Ser Gln Met Asn Asn Ile Met Ser Lys Ser 
                645                 650                 655     


Leu His Asp Asp Gly Phe Thr Val Pro Gln Ile Ile Glu Met Glu Leu 
            660                 665                 670         


Asp Ser Gln Glu Gln Leu Leu Leu Gln Asp Pro Pro Val Thr Tyr Ile 
        675                 680                 685             


Gln Gln Phe Ala Asp Ala Ala Ala Asn Leu Thr Ser Pro Asp Ser Glu 
    690                 695                 700                 


Lys Trp Asn Ser Val Phe Pro Lys Pro Gly Thr Leu Val Gln Cys Leu 
705                 710                 715                 720 


Arg Leu Pro Lys Phe Ala Glu Glu Glu Asn Leu Cys Ile Asp Ser Ile 
                725                 730                 735     


Thr Pro Cys Ala Asp Gly Ile His Leu Leu Val Gly Leu Arg Thr Cys 
            740                 745                 750         


Pro Val Glu Ser Leu Ser Ala Ile Asn Gln Val Glu Ala Leu Asn Asn 
        755                 760                 765             


Leu Asn Lys Leu Asn Ser Ala Leu Cys Asn Arg Arg Lys Gly Glu Leu 
    770                 775                 780                 


Glu Ser Asn Leu Ala Val Val Asn Gly Ala Asn Ile Ser Val Ile Gln 
785                 790                 795                 800 


His Glu Ser Pro Ala Asp Val Gln Thr Pro Leu Ile Ile Gln Pro Glu 
                805                 810                 815     


Gln Arg Asn Val Ser Gly Gly Tyr Leu Val Leu Tyr Lys Met Asn Tyr 
            820                 825                 830         


Ala Thr Arg Ile Val Thr Leu Glu Glu Glu Pro Ile Lys Ile Gln His 
        835                 840                 845             


Ile Lys Asp Pro Gln Asp Thr Ile Thr Ser Leu Ile Leu Leu Pro Pro 
    850                 855                 860                 


Asp Ile Leu Asp Asn Arg Glu Asp Asp Cys Glu Glu Pro Ile Glu Asp 
865                 870                 875                 880 


Met Gln Leu Thr Ser Lys Asn Gly Phe Glu Arg Glu Lys Thr Ser Asp 
                885                 890                 895     


Ile Ser Thr Leu Gly His Leu Val Ile Thr Thr Gln Gly Gly Tyr Val 
            900                 905                 910         


Lys Ile Leu Asp Leu Ser Asn Phe Glu Ile Leu Ala Lys Val Glu Pro 
        915                 920                 925             


Pro Lys Lys Glu Gly Thr Glu Glu Gln Asp Thr Phe Val Ser Val Ile 
    930                 935                 940                 


Tyr Cys Ser Gly Thr Asp Arg Leu Cys Ala Cys Thr Lys Gly Gly Glu 
945                 950                 955                 960 


Leu His Phe Leu Gln Ile Gly Gly Thr Cys Asp Asp Ile Asp Glu Ala 
                965                 970                 975     


Asp Ile Leu Val Asp Gly Ser Leu Ser Lys Gly Ile Glu Pro Ser Ser 
            980                 985                 990         


Glu Gly Ser Lys Pro Leu Ser Asn  Pro Ser Ser Pro Gly  Ile Ser Gly 
        995                 1000                 1005             


Val Asp  Leu Leu Val Asp Gln  Pro Phe Thr Leu Glu  Ile Leu Thr 
    1010                 1015                 1020             


Ser Leu  Val Glu Leu Thr Arg  Phe Glu Thr Leu Thr  Pro Arg Phe 
    1025                 1030                 1035             


Ser Ala  Thr Val Pro Pro Cys  Trp Val Glu Val Gln  Gln Glu Gln 
    1040                 1045                 1050             


Gln Gln  Arg Arg His Pro Gln  His Leu His Gln Gln  His His Gly 
    1055                 1060                 1065             


Asp Ala  Ala Gln His Thr Arg  Thr Trp Lys Leu Gln  Thr Asp Ser 
    1070                 1075                 1080             


Asn Ser  Trp Asp Glu His Val  Phe Glu Leu Val Leu  Pro Lys Ala 
    1085                 1090                 1095             


Cys Met  Val Gly His Val Asp  Phe Lys Phe Val Leu  Asn Ser Asn 
    1100                 1105                 1110             


Ile Thr  Asn Ile Pro Gln Ile  Gln Val Thr Leu Leu  Lys Asn Lys 
    1115                 1120                 1125             


Ala Pro  Gly Leu Gly Lys Val  Asn Ala Leu Asn Ile  Glu Val Glu 
    1130                 1135                 1140             


Gln Asn  Gly Lys Pro Ser Leu  Val Asp Leu Asn Glu  Glu Met Gln 
    1145                 1150                 1155             


His Met  Asp Val Glu Glu Ser  Gln Cys Leu Arg Leu  Cys Pro Phe 
    1160                 1165                 1170             


Leu Glu  Asp His Lys Glu Asp  Ile Leu Cys Gly Pro  Val Trp Leu 
    1175                 1180                 1185             


Ala Ser  Gly Leu Asp Leu Ser  Gly His Ala Gly Met  Leu Thr Leu 
    1190                 1195                 1200             


Thr Ser  Pro Lys Leu Val Lys  Gly Met Ala Gly Gly  Lys Tyr Arg 
    1205                 1210                 1215             


Ser Phe  Leu Ile His Val Lys  Ala Val Asn Glu Arg  Gly Thr Glu 
    1220                 1225                 1230             


Glu Ile  Cys Asn Gly Gly Met  Arg Pro Val Val Arg  Leu Pro Ser 
    1235                 1240                 1245             


Leu Lys  His Gln Ser Asn Lys  Gly Tyr Ser Leu Ala  Ser Leu Leu 
    1250                 1255                 1260             


Ala Lys  Val Ala Ala Gly Lys  Glu Lys Ser Ser Asn  Val Lys Asn 
    1265                 1270                 1275             


Glu Asn  Thr Ser Gly Thr Arg  Lys Ser Glu Asn Leu  Arg Gly Cys 
    1280                 1285                 1290             


Asp Leu  Leu Gln Glu Val Ser  Val Thr Ile Arg Arg  Phe Lys Lys 
    1295                 1300                 1305             


Thr Ser  Ile Ser Lys Glu Arg  Val Gln Arg Cys Ala  Met Leu Gln 
    1310                 1315                 1320             


Phe Ser  Glu Phe His Glu Lys  Leu Leu Asn Thr Leu  Cys Arg Lys 
    1325                 1330                 1335             


Thr Asp  Asp Gly Gln Ile Thr  Glu His Ala Gln Ser  Leu Val Leu 
    1340                 1345                 1350             


Asp Thr  Leu Cys Trp Leu Ala  Gly Val His Ser Asn  Gly Pro Gly 
    1355                 1360                 1365             


Ser Ser  Lys Glu Gly Asn Glu  Asn Leu Leu Ser Lys  Thr Arg Lys 
    1370                 1375                 1380             


Phe Leu  Ser Asp Ile Val Arg  Val Cys Phe Phe Glu  Ala Gly Arg 
    1385                 1390                 1395             


Ser Ile  Ala His Lys Cys Ala  Arg Phe Leu Ala Leu  Cys Ile Ser 
    1400                 1405                 1410             


Asn Gly  Lys Cys Asp Pro Cys  Gln Pro Ala Phe Gly  Pro Val Leu 
    1415                 1420                 1425             


Leu Lys  Ala Leu Leu Asp Asn  Met Ser Phe Leu Pro  Ala Ala Thr 
    1430                 1435                 1440             


Thr Gly  Gly Ser Val Tyr Trp  Tyr Phe Val Leu Leu  Asn Tyr Val 
    1445                 1450                 1455             


Lys Asp  Glu Asp Leu Ala Gly  Cys Ser Thr Ala Cys  Ala Ser Leu 
    1460                 1465                 1470             


Leu Thr  Ala Val Ser Arg Gln  Leu Gln Asp Arg Leu  Thr Pro Met 
    1475                 1480                 1485             


Glu Ala  Leu Leu Gln Thr Arg  Tyr Gly Leu Tyr Ser  Ser Pro Phe 
    1490                 1495                 1500             


Asp Pro  Val Leu Phe Asp Leu  Glu Met Ser Gly Ser  Ser Cys Lys 
    1505                 1510                 1515             


Asn Val  Tyr Asn Ser Ser Ile  Gly Val Gln Ser Asp  Glu Ile Asp 
    1520                 1525                 1530             


Leu Ser  Asp Val Leu Ser Gly  Asn Gly Lys Val Ser  Ser Cys Thr 
    1535                 1540                 1545             


Ala Ala  Glu Gly Ser Phe Thr  Ser Leu Thr Gly Leu  Leu Glu Val 
    1550                 1555                 1560             


Glu Pro  Leu His Phe Thr Cys  Val Ser Thr Ser Asp  Gly Thr Arg 
    1565                 1570                 1575             


Ile Glu  Arg Asp Asp Ala Met  Ser Ser Phe Gly Val  Thr Pro Ala 
    1580                 1585                 1590             


Val Gly  Gly Leu Ser Ser Gly  Thr Val Gly Glu Ala  Ser Thr Ala 
    1595                 1600                 1605             


Leu Ser  Ser Ala Ala Gln Val  Ala Leu Gln Ser Leu  Ser His Ala 
    1610                 1615                 1620             


Met Ala  Ser Ala Glu Gln Gln  Leu Gln Val Leu Gln  Glu Lys Gln 
    1625                 1630                 1635             


Gln Gln  Leu Leu Lys Leu Gln  Gln Gln Lys Ala Lys  Leu Glu Ala 
    1640                 1645                 1650             


Lys Leu  His Gln Thr Thr Ala  Ala Ala Ala Ala Ala  Ala Ser Ala 
    1655                 1660                 1665             


Val Gly  Pro Val His Asn Ser  Val Pro Ser Asn Pro  Val Ala Ala 
    1670                 1675                 1680             


Pro Gly  Phe Phe Ile His Pro  Ser Asp Val Ile Pro  Pro Thr Pro 
    1685                 1690                 1695             


Lys Thr  Thr Pro Leu Phe Met  Thr Pro Pro Leu Thr  Pro Pro Asn 
    1700                 1705                 1710             


Glu Ala  Val Ser Val Val Ile  Asn Ala Glu Leu Ala  Gln Leu Phe 
    1715                 1720                 1725             


Pro Gly  Ser Val Ile Asp Pro  Pro Ala Val Asn Leu  Ala Ala His 
    1730                 1735                 1740             


Asn Lys  Asn Ser Asn Lys Ser  Arg Met Asn Pro Leu  Gly Ser Gly 
    1745                 1750                 1755             


Leu Ala  Leu Ala Ile Ser His  Ala Ser His Phe Leu  Gln Pro Pro 
    1760                 1765                 1770             


Pro His  Gln Ser Ile Ile Ile  Glu Arg Met His Ser  Gly Ala Arg 
    1775                 1780                 1785             


Arg Phe  Val Thr Leu Asp Phe  Gly Arg Pro Ile Leu  Leu Thr Asp 
    1790                 1795                 1800             


Val Leu  Ile Pro Thr Cys Gly  Asp Leu Ala Ser Leu  Ser Ile Asp 
    1805                 1810                 1815             


Ile Trp  Thr Leu Gly Glu Glu  Val Asp Gly Arg Arg  Leu Val Val 
    1820                 1825                 1830             


Ala Thr  Asp Ile Ser Thr His  Ser Leu Ile Leu His  Asp Leu Ile 
    1835                 1840                 1845             


Pro Pro  Pro Val Cys Arg Phe  Met Lys Ile Thr Val  Ile Gly Arg 
    1850                 1855                 1860             


Tyr Gly  Ser Thr Asn Ala Arg  Ala Lys Ile Pro Leu  Gly Phe Tyr 
    1865                 1870                 1875             


Tyr Gly  His Thr Tyr Ile Leu  Pro Trp Glu Ser Glu  Leu Lys Leu 
    1880                 1885                 1890             


Met His  Asp Pro Leu Lys Gly  Glu Gly Glu Ser Ala  Asn Gln Pro 
    1895                 1900                 1905             


Glu Ile  Asp Gln His Leu Ala  Met Met Val Ala Leu  Gln Glu Asp 
    1910                 1915                 1920             


Ile Gln  Cys Arg Tyr Asn Leu  Ala Cys His Arg Leu  Glu Thr Leu 
    1925                 1930                 1935             


Leu Gln  Ser Ile Asp Leu Pro  Pro Leu Asn Ser Ala  Asn Asn Ala 
    1940                 1945                 1950             


Gln Tyr  Phe Leu Arg Lys Pro  Asp Lys Ala Val Glu  Glu Asp Ser 
    1955                 1960                 1965             


Arg Val  Phe Ser Ala Tyr Gln  Asp Cys Ile Gln Leu  Gln Leu Gln 
    1970                 1975                 1980             


Leu Asn  Leu Ala His Asn Ala  Val Gln Arg Leu Lys  Val Ala Leu 
    1985                 1990                 1995             


Gly Ala  Ser Arg Lys Met Leu  Ser Glu Thr Ser Asn  Pro Glu Asp 
    2000                 2005                 2010             


Leu Ile  Gln Thr Ser Ser Thr  Glu Gln Leu Arg Thr  Ile Ile Arg 
    2015                 2020                 2025             


Tyr Leu  Leu Asp Thr Leu Leu  Ser Leu Leu His Ala  Ser Asn Gly 
    2030                 2035                 2040             


His Ser  Val Pro Ala Val Leu  Gln Ser Thr Phe His  Ala Gln Ala 
    2045                 2050                 2055             


Cys Glu  Glu Leu Phe Lys His  Leu Cys Ile Ser Gly  Thr Pro Lys 
    2060                 2065                 2070             


Ile Arg  Leu His Thr Gly Leu  Leu Leu Val Gln Leu  Cys Gly Gly 
    2075                 2080                 2085             


Glu Arg  Trp Trp Gly Gln Phe  Leu Ser Asn Val Leu  Gln Glu Leu 
    2090                 2095                 2100             


Tyr Asn  Ser Glu Gln Leu Leu  Ile Phe Pro Gln Asp  Arg Val Phe 
    2105                 2110                 2115             


Met Leu  Leu Ser Cys Ile Gly  Gln Arg Ser Leu Ser  Asn Ser Gly 
    2120                 2125                 2130             


Val Leu  Glu Ser Leu Leu Asn  Leu Leu Asp Asn Leu  Leu Ser Pro 
    2135                 2140                 2145             


Leu Gln  Pro Gln Leu Pro Met  His Arg Arg Thr Glu  Gly Val Leu 
    2150                 2155                 2160             


Asp Ile  Pro Met Ile Ser Trp  Val Val Met Leu Val  Ser Arg Leu 
    2165                 2170                 2175             


Leu Asp  Tyr Val Ala Thr Val  Glu Asp Glu Ala Ala  Ala Ala Lys 
    2180                 2185                 2190             


Lys Pro  Leu Asn Gly Asn Gln  Trp Ser Phe Ile Asn  Asn Asn Leu 
    2195                 2200                 2205             


His Thr  Gln Ser Leu Asn Arg  Ser Ser Lys Gly Ser  Ser Ser Leu 
    2210                 2215                 2220             


Asp Arg  Leu Tyr Ser Arg Lys  Ile Arg Lys Gln Leu  Val His His 
    2225                 2230                 2235             


Lys Gln  Gln Leu Asn Leu Leu  Lys Ala Lys Gln Lys  Ala Leu Val 
    2240                 2245                 2250             


Glu Gln  Met Glu Lys Glu Lys  Ile Gln Ser Asn Lys  Gly Ser Ser 
    2255                 2260                 2265             


Tyr Lys  Leu Leu Val Glu Gln  Ala Lys Leu Lys Gln  Ala Thr Ser 
    2270                 2275                 2280             


Lys His  Phe Lys Asp Leu Ile  Arg Leu Arg Arg Thr  Ala Glu Trp 
    2285                 2290                 2295             


Ser Arg  Ser Asn Leu Asp Thr  Glu Val Thr Thr Ala  Lys Glu Ser 
    2300                 2305                 2310             


Pro Glu  Ile Glu Pro Leu Pro  Phe Thr Leu Ala His  Glu Arg Cys 
    2315                 2320                 2325             


Ile Ser  Val Val Gln Lys Leu  Val Leu Phe Leu Leu  Ser Met Asp 
    2330                 2335                 2340             


Phe Thr  Cys His Ala Asp Leu  Leu Leu Phe Val Cys  Lys Val Leu 
    2345                 2350                 2355             


Ala Arg  Ile Ala Asn Ala Thr  Arg Pro Thr Ile His  Leu Cys Glu 
    2360                 2365                 2370             


Ile Val  Asn Glu Pro Gln Leu  Glu Arg Leu Leu Leu  Leu Leu Val 
    2375                 2380                 2385             


Gly Thr  Asp Phe Asn Arg Gly  Asp Ile Ser Trp Gly  Gly Ala Trp 
    2390                 2395                 2400             


Ala Gln  Tyr Ser Leu Thr Cys  Met Leu Gln Asp Ile  Leu Ala Gly 
    2405                 2410                 2415             


Glu Leu  Leu Ala Pro Val Ala  Ala Glu Ala Met Glu  Glu Gly Thr 
    2420                 2425                 2430             


Val Gly  Asp Asp Val Gly Ala  Thr Ala Gly Asp Ser  Asp Asp Ser 
    2435                 2440                 2445             


Leu Gln  Gln Ser Ser Val Gln  Leu Leu Glu Thr Ile  Asp Glu Pro 
    2450                 2455                 2460             


Leu Thr  His Asp Ile Thr Gly  Ala Pro Pro Leu Ser  Ser Leu Glu 
    2465                 2470                 2475             


Lys Asp  Lys Glu Ile Asp Leu  Glu Leu Leu Gln Asp  Leu Met Glu 
    2480                 2485                 2490             


Val Asp  Ile Asp Pro Leu Asp  Ile Asp Leu Glu Lys  Asp Pro Leu 
    2495                 2500                 2505             


Ala Ala  Lys Val Phe Lys Pro  Ile Ser Ser Thr Trp  Tyr Asp Tyr 
    2510                 2515                 2520             


Trp Gly  Ala Asp Tyr Gly Thr  Tyr Asn Tyr Asn Pro  Tyr Ile Gly 
    2525                 2530                 2535             


Gly Leu  Gly Ile Pro Val Ala  Lys Pro Pro Ala Asn  Thr Glu Lys 
    2540                 2545                 2550             


Asn Gly  Ser Gln Thr Val Ser  Val Ser Val Ser Gln  Ala Leu Asp 
    2555                 2560                 2565             


Ala Arg  Leu Glu Val Gly Leu  Glu Gln Gln Ala Glu  Leu Met Leu 
    2570                 2575                 2580             


Lys Met  Met Ser Thr Leu Glu  Ala Asp Ser Ile Leu  Gln Ala Leu 
    2585                 2590                 2595             


Thr Asn  Thr Ser Pro Thr Leu  Ser Gln Ser Pro Thr  Gly Thr Asp 
    2600                 2605                 2610             


Asp Ser  Leu Leu Gly Gly Leu  Gln Ala Ala Asn Gln  Thr Ser Gln 
    2615                 2620                 2625             


Leu Ile  Ile Gln Leu Ser Ser  Val Pro Met Leu Asn  Val Cys Phe 
    2630                 2635                 2640             


Asn Lys  Leu Phe Ser Met Leu  Gln Val His His Val  Gln Leu Glu 
    2645                 2650                 2655             


Ser Leu  Leu Gln Leu Trp Leu  Thr Leu Ser Leu Asn  Ser Ser Ser 
    2660                 2665                 2670             


Thr Gly  Asn Lys Glu Asn Gly  Ala Asp Ile Phe Leu  Tyr Asn Ala 
    2675                 2680                 2685             


Asn Arg  Ile Pro Val Ile Ser  Leu Asn Gln Ala Ser  Ile Thr Ser 
    2690                 2695                 2700             


Phe Leu  Thr Val Leu Ala Trp  Tyr Pro Asn Thr Leu  Leu Arg Thr 
    2705                 2710                 2715             


Trp Cys  Leu Val Leu His Ser  Leu Thr Leu Met Thr  Asn Met Gln 
    2720                 2725                 2730             


Leu Asn  Ser Gly Ser Ser Ser  Ala Ile Gly Thr Gln  Glu Ser Thr 
    2735                 2740                 2745             


Ala His  Leu Leu Val Ser Asp  Pro Asn Leu Ile His  Val Leu Val 
    2750                 2755                 2760             


Lys Phe  Leu Ser Gly Thr Ser  Pro His Gly Thr Asn  Gln His Ser 
    2765                 2770                 2775             


Pro Gln  Val Gly Pro Thr Ala  Thr Gln Ala Met Gln  Glu Phe Leu 
    2780                 2785                 2790             


Thr Arg  Leu Gln Val His Leu  Ser Ser Thr Cys Pro  Gln Ile Phe 
    2795                 2800                 2805             


Ser Glu  Phe Leu Leu Lys Leu  Ile His Ile Leu Ser  Thr Glu Arg 
    2810                 2815                 2820             


Gly Ala  Phe Gln Thr Gly Gln  Gly Pro Leu Asp Ala  Gln Val Lys 
    2825                 2830                 2835             


Leu Leu  Glu Phe Thr Leu Glu  Gln Asn Phe Glu Val  Val Ser Val 
    2840                 2845                 2850             


Ser Thr  Ile Ser Ala Val Ile  Glu Ser Val Thr Phe  Leu Val His 
    2855                 2860                 2865             


His Tyr  Ile Thr Cys Ser Asp  Lys Val Met Ser Arg  Ser Gly Ser 
    2870                 2875                 2880             


Asp Ser  Ser Val Gly Ala Arg  Ala Cys Phe Gly Gly  Leu Phe Ala 
    2885                 2890                 2895             


Asn Leu  Ile Arg Pro Gly Asp  Ala Lys Ala Val Cys  Gly Glu Met 
    2900                 2905                 2910             


Thr Arg  Asp Gln Leu Met Phe  Asp Leu Leu Lys Leu  Val Asn Ile 
    2915                 2920                 2925             


Leu Val  Gln Leu Pro Leu Ser  Gly Asn Arg Glu Tyr  Ser Ala Arg 
    2930                 2935                 2940             


Val Ser  Val Thr Thr Asn Thr  Thr Asp Ser Val Ser  Asp Glu Glu 
    2945                 2950                 2955             


Lys Val  Ser Gly Gly Lys Asp  Gly Asn Gly Ser Ser  Thr Ser Val 
    2960                 2965                 2970             


Gln Gly  Ser Pro Ala Tyr Val  Ala Asp Leu Val Leu  Ala Asn Gln 
    2975                 2980                 2985             


Gln Ile  Met Ser Gln Ile Leu  Ser Ala Leu Gly Leu  Cys Asn Ser 
    2990                 2995                 3000             


Ser Ala  Met Ala Met Ile Ile  Gly Ala Ser Gly Leu  His Leu Thr 
    3005                 3010                 3015             


Lys His  Glu Asn Phe His Gly  Gly Leu Asp Ala Ile  Ser Val Gly 
    3020                 3025                 3030             


Asp Gly  Leu Phe Thr Ile Leu  Thr Thr Leu Ser Lys  Lys Ala Ser 
    3035                 3040                 3045             


Thr Val  His Met Met Leu Gln  Pro Ile Leu Thr Tyr  Met Ala Cys 
    3050                 3055                 3060             


Gly Tyr  Met Gly Arg Gln Gly  Ser Leu Ala Thr Cys  Gln Leu Ser 
    3065                 3070                 3075             


Glu Pro  Leu Leu Trp Phe Ile  Leu Arg Val Leu Asp  Thr Ser Asp 
    3080                 3085                 3090             


Ala Leu  Lys Ala Phe His Asp  Met Gly Gly Val Gln  Leu Ile Cys 
    3095                 3100                 3105             


Asn Asn  Met Val Thr Ser Thr  Arg Ala Ile Val Asn  Thr Ala Arg 
    3110                 3115                 3120             


Ser Met  Val Ser Thr Ile Met  Lys Phe Leu Asp Ser  Gly Pro Asn 
    3125                 3130                 3135             


Lys Ala  Val Asp Ser Thr Leu  Lys Thr Arg Ile Leu  Ala Ser Glu 
    3140                 3145                 3150             


Pro Asp  Asn Ala Glu Gly Ile  His Asn Phe Ala Pro  Leu Gly Thr 
    3155                 3160                 3165             


Ile Thr  Ser Ser Ser Pro Thr  Ala Gln Pro Ala Glu  Val Leu Leu 
    3170                 3175                 3180             


Gln Ala  Thr Pro Pro His Arg  Arg Ala Arg Ser Ala  Ala Trp Ser 
    3185                 3190                 3195             


Tyr Ile  Phe Leu Pro Glu Glu  Ala Trp Cys Asp Leu  Thr Ile His 
    3200                 3205                 3210             


Leu Pro  Ala Ala Val Leu Leu  Lys Glu Ile His Ile  Gln Pro His 
    3215                 3220                 3225             


Leu Ala  Ser Leu Ala Thr Cys  Pro Ser Ser Val Ser  Val Glu Val 
    3230                 3235                 3240             


Ser Ala  Asp Gly Val Asn Met  Leu Pro Leu Ser Thr  Pro Val Val 
    3245                 3250                 3255             


Thr Ser  Gly Leu Thr Tyr Ile  Lys Ile Gln Leu Val  Lys Ala Glu 
    3260                 3265                 3270             


Val Ala  Ser Ala Val Cys Leu  Arg Leu His Arg Pro  Arg Asp Ala 
    3275                 3280                 3285             


Ser Thr  Leu Gly Leu Ser Gln  Ile Lys Leu Leu Gly  Leu Thr Ala 
    3290                 3295                 3300             


Phe Gly  Thr Thr Ser Ser Ala  Thr Val Asn Asn Pro  Phe Leu Pro 
    3305                 3310                 3315             


Ser Glu  Asp Gln Val Ser Lys  Thr Ser Ile Gly Trp  Leu Arg Leu 
    3320                 3325                 3330             


Leu His  His Cys Leu Thr His  Ile Ser Asp Leu Glu  Gly Met Met 
    3335                 3340                 3345             


Ala Ser  Ala Ala Ala Pro Thr  Ala Asn Leu Leu Gln  Thr Cys Ala 
    3350                 3355                 3360             


Ala Leu  Leu Met Ser Pro Tyr  Cys Gly Met His Ser  Pro Asn Ile 
    3365                 3370                 3375             


Glu Val  Val Leu Val Lys Ile  Gly Leu Gln Ser Thr  Arg Ile Gly 
    3380                 3385                 3390             


Leu Lys  Leu Ile Asp Ile Leu  Leu Arg Asn Cys Ala  Ala Ser Gly 
    3395                 3400                 3405             


Ser Asp  Pro Thr Asp Leu Asn  Ser Pro Leu Leu Phe  Gly Arg Leu 
    3410                 3415                 3420             


Asn Gly  Leu Ser Ser Asp Ser  Thr Ile Asp Ile Leu  Tyr Gln Leu 
    3425                 3430                 3435             


Gly Thr  Thr Gln Asp Pro Gly  Thr Lys Asp Arg Ile  Gln Ala Leu 
    3440                 3445                 3450             


Leu Lys  Trp Val Ser Asp Ser  Ala Arg Val Ala Ala  Met Lys Arg 
    3455                 3460                 3465             


Ser Gly  Arg Met Asn Tyr Met  Cys Pro Asn Ser Ser  Thr Val Glu 
    3470                 3475                 3480             


Tyr Gly  Leu Leu Met Pro Ser  Pro Ser His Leu His  Cys Val Ala 
    3485                 3490                 3495             


Ala Ile  Leu Trp His Ser Tyr  Glu Leu Leu Val Glu  Tyr Asp Leu 
    3500                 3505                 3510             


Pro Ala  Leu Leu Asp Gln Glu  Leu Phe Glu Leu Leu  Phe Asn Trp 
    3515                 3520                 3525             


Ser Met  Ser Leu Pro Cys Asn  Met Val Leu Lys Lys  Ala Val Asp 
    3530                 3535                 3540             


Ser Leu  Leu Cys Ser Met Cys  His Val His Pro Asn  Tyr Phe Ser 
    3545                 3550                 3555             


Leu Leu  Met Gly Trp Met Gly  Ile Thr Pro Pro Pro  Val Gln Cys 
    3560                 3565                 3570             


His His  Arg Leu Ser Met Thr  Asp Asp Ser Lys Lys  Gln Asp Leu 
    3575                 3580                 3585             


Ser Ser  Ser Leu Thr Asp Asp  Ser Lys Asn Ala Gln  Ala Pro Leu 
    3590                 3595                 3600             


Ala Leu  Thr Glu Ser His Leu  Ala Thr Leu Ala Ser  Ser Ser Gln 
    3605                 3610                 3615             


Ser Pro  Glu Ala Ile Lys Gln  Leu Leu Asp Ser Gly  Leu Pro Ser 
    3620                 3625                 3630             


Leu Leu  Val Arg Ser Leu Ala  Ser Phe Cys Phe Ser  His Ile Ser 
    3635                 3640                 3645             


Ser Ser  Glu Ser Ile Ala Gln  Ser Ile Asp Ile Ser  Gln Asp Lys 
    3650                 3655                 3660             


Leu Arg  Arg His His Val Pro  Gln Gln Cys Asn Lys  Met Pro Ile 
    3665                 3670                 3675             


Thr Ala  Asp Leu Val Ala Pro  Ile Leu Arg Phe Leu  Thr Glu Val 
    3680                 3685                 3690             


Gly Asn  Ser His Ile Met Lys  Asp Trp Leu Gly Gly  Ser Glu Val 
    3695                 3700                 3705             


Asn Pro  Leu Trp Thr Ala Leu  Leu Phe Leu Leu Cys  His Ser Gly 
    3710                 3715                 3720             


Ser Thr  Ser Gly Ser His Asn  Leu Gly Ala Gln Gln  Thr Ser Ala 
    3725                 3730                 3735             


Arg Ser  Ala Ser Leu Ser Ser  Ala Ala Thr Thr Gly  Leu Thr Thr 
    3740                 3745                 3750             


Gln Gln  Arg Thr Ala Ile Glu  Asn Ala Thr Val Ala  Phe Phe Leu 
    3755                 3760                 3765             


Gln Cys  Ile Ser Cys His Pro  Asn Asn Gln Lys Leu  Met Ala Gln 
    3770                 3775                 3780             


Val Leu  Cys Glu Leu Phe Gln  Thr Ser Pro Gln Arg  Gly Asn Leu 
    3785                 3790                 3795             


Pro Thr  Ser Gly Asn Ile Ser  Gly Phe Ile Arg Arg  Leu Phe Leu 
    3800                 3805                 3810             


Gln Leu  Met Leu Glu Asp Glu  Lys Val Thr Met Phe  Leu Gln Ser 
    3815                 3820                 3825             


Pro Cys  Pro Leu Tyr Lys Gly  Arg Ile Asn Ala Thr  Ser His Val 
    3830                 3835                 3840             


Ile Gln  His Pro Met Tyr Gly  Ala Gly His Lys Phe  Arg Thr Leu 
    3845                 3850                 3855             


His Leu  Pro Val Ser Thr Thr  Leu Ser Asp Val Leu  Asp Arg Val 
    3860                 3865                 3870             


Ser Asp  Thr Pro Ser Ile Thr  Ala Lys Leu Ile Ser  Glu Gln Lys 
    3875                 3880                 3885             


Asp Asp  Lys Glu Lys Lys Asn  His Glu Glu Lys Glu  Lys Val Lys 
    3890                 3895                 3900             


Ala Glu  Asn Gly Phe Gln Asp  Asn Tyr Ser Val Val  Val Ala Ser 
    3905                 3910                 3915             


Gly Leu  Lys Ser Gln Ser Lys  Arg Ala Val Ser Ala  Thr Pro Pro 
    3920                 3925                 3930             


Arg Pro  Pro Ser Arg Arg Gly  Arg Thr Ile Pro Asp  Lys Ile Gly 
    3935                 3940                 3945             


Ser Thr  Ser Gly Ala Glu Ala  Ala Asn Lys Ile Ile  Thr Val Pro 
    3950                 3955                 3960             


Val Phe  His Leu Phe His Lys  Leu Leu Ala Gly Gln  Pro Leu Pro 
    3965                 3970                 3975             


Ala Glu  Met Thr Leu Ala Gln  Leu Leu Thr Leu Leu  Tyr Asp Arg 
    3980                 3985                 3990             


Lys Leu  Pro Gln Gly Tyr Arg  Ser Ile Asp Leu Thr  Val Lys Leu 
    3995                 4000                 4005             


Gly Ser  Arg Val Ile Thr Asp  Pro Ser Leu Ser Lys  Thr Asp Ser 
    4010                 4015                 4020             


Tyr Lys  Arg Leu His Pro Glu  Lys Asp His Gly Asp  Leu Leu Ala 
    4025                 4030                 4035             


Ser Cys  Pro Glu Asp Glu Ala  Leu Thr Pro Gly Asp  Glu Cys Met 
    4040                 4045                 4050             


Asp Gly  Ile Leu Asp Glu Ser  Leu Leu Glu Thr Cys  Pro Ile Gln 
    4055                 4060                 4065             


Ser Pro  Leu Gln Val Phe Ala  Gly Met Gly Gly Leu  Ala Leu Ile 
    4070                 4075                 4080             


Ala Glu  Arg Leu Pro Met Leu  Tyr Pro Glu Val Ile  Gln Gln Val 
    4085                 4090                 4095             


Ser Ala  Pro Val Val Thr Ser  Thr Thr Gln Glu Lys  Pro Lys Asp 
    4100                 4105                 4110             


Ser Asp  Gln Phe Glu Trp Val  Thr Ile Glu Gln Ser  Gly Glu Leu 
    4115                 4120                 4125             


Val Tyr  Glu Ala Pro Glu Thr  Val Ala Ala Glu Pro  Pro Pro Ile 
    4130                 4135                 4140             


Lys Ser  Ala Val Gln Thr Met  Ser Pro Ile Pro Ala  His Ser Leu 
    4145                 4150                 4155             


Ala Ala  Phe Gly Leu Phe Leu  Arg Leu Pro Gly Tyr  Ala Glu Val 
    4160                 4165                 4170             


Leu Leu  Lys Glu Arg Lys His  Ala Gln Cys Leu Leu  Arg Leu Val 
    4175                 4180                 4185             


Leu Gly  Val Thr Asp Asp Gly  Glu Gly Ser His Ile  Leu Gln Ser 
    4190                 4195                 4200             


Pro Ser  Ala Asn Val Leu Pro  Thr Leu Pro Phe His  Val Leu Arg 
    4205                 4210                 4215             


Ser Leu  Phe Ser Thr Thr Pro  Leu Thr Thr Asp Asp  Gly Val Leu 
    4220                 4225                 4230             


Leu Arg  Arg Met Ala Leu Glu  Ile Gly Ala Leu His  Leu Ile Leu 
    4235                 4240                 4245             


Val Cys  Leu Ser Ala Leu Ser  His His Ser Pro Arg  Val Pro Asn 
    4250                 4255                 4260             


Ser Ser  Val Asn Gln Thr Glu  Pro Gln Val Ser Ser  Ser His Asn 
    4265                 4270                 4275             


Pro Thr  Ser Thr Glu Glu Gln  Gln Leu Tyr Trp Ala  Lys Gly Thr 
    4280                 4285                 4290             


Gly Phe  Gly Thr Gly Ser Thr  Ala Ser Gly Trp Asp  Val Glu Gln 
    4295                 4300                 4305             


Ala Leu  Thr Lys Gln Arg Leu  Glu Glu Glu His Val  Thr Cys Leu 
    4310                 4315                 4320             


Leu Gln  Val Leu Ala Ser Tyr  Ile Asn Pro Val Ser  Ser Ala Val 
    4325                 4330                 4335             


Asn Gly  Glu Ala Gln Ser Ser  His Glu Thr Arg Gly  Gln Asn Ser 
    4340                 4345                 4350             


Asn Ala  Leu Pro Ser Val Leu  Leu Glu Leu Leu Ser  Gln Ser Cys 
    4355                 4360                 4365             


Leu Ile  Pro Ala Met Ser Ser  Tyr Leu Arg Asn Asp  Ser Val Leu 
    4370                 4375                 4380             


Asp Met  Ala Arg His Val Pro  Leu Tyr Arg Ala Leu  Leu Glu Leu 
    4385                 4390                 4395             


Leu Arg  Ala Ile Ala Ser Cys  Ala Ala Met Val Pro  Leu Leu Leu 
    4400                 4405                 4410             


Pro Leu  Ser Thr Glu Asn Gly  Glu Glu Glu Glu Glu  Gln Ser Glu 
    4415                 4420                 4425             


Cys Gln  Thr Ser Val Gly Thr  Leu Leu Ala Lys Met  Lys Thr Cys 
    4430                 4435                 4440             


Val Asp  Thr Tyr Thr Asn Arg  Leu Arg Ser Lys Arg  Glu Asn Val 
    4445                 4450                 4455             


Lys Thr  Gly Val Lys Pro Asp  Ala Ser Asp Gln Glu  Pro Glu Gly 
    4460                 4465                 4470             


Leu Thr  Leu Leu Val Pro Asp  Ile Gln Lys Thr Ala  Glu Ile Val 
    4475                 4480                 4485             


Tyr Ala  Ala Thr Thr Ser Leu  Arg Gln Ala Asn Gln  Glu Lys Lys 
    4490                 4495                 4500             


Leu Gly  Glu Tyr Ser Lys Lys  Ala Ala Met Lys Pro  Lys Pro Leu 
    4505                 4510                 4515             


Ser Val  Leu Lys Ser Leu Glu  Glu Lys Tyr Val Ala  Val Met Lys 
    4520                 4525                 4530             


Lys Leu  Gln Phe Asp Thr Phe  Glu Met Val Ser Glu  Asp Glu Asp 
    4535                 4540                 4545             


Gly Lys  Leu Gly Phe Lys Val  Asn Tyr His Tyr Met  Ser Gln Val 
    4550                 4555                 4560             


Lys Asn  Ala Asn Asp Ala Asn  Ser Ala Ala Arg Ala  Arg Arg Leu 
    4565                 4570                 4575             


Ala Gln  Glu Ala Val Thr Leu  Ser Thr Ser Leu Pro  Leu Ser Ser 
    4580                 4585                 4590             


Ser Ser  Ser Val Phe Val Arg  Cys Asp Glu Glu Arg  Leu Asp Ile 
    4595                 4600                 4605             


Met Lys  Val Leu Ile Thr Gly  Pro Ala Asp Thr Pro  Tyr Ala Asn 
    4610                 4615                 4620             


Gly Cys  Phe Glu Phe Asp Val  Tyr Phe Pro Gln Asp  Tyr Pro Ser 
    4625                 4630                 4635             


Ser Pro  Pro Leu Val Asn Leu  Glu Thr Thr Gly Gly  His Ser Val 
    4640                 4645                 4650             


Arg Phe  Asn Pro Asn Leu Tyr  Asn Asp Gly Lys Val  Cys Leu Ser 
    4655                 4660                 4665             


Ile Leu  Asn Thr Trp His Gly  Arg Pro Glu Glu Lys  Trp Asn Pro 
    4670                 4675                 4680             


Gln Thr  Ser Ser Phe Leu Gln  Val Leu Val Ser Val  Gln Ser Leu 
    4685                 4690                 4695             


Ile Leu  Val Ala Glu Pro Tyr  Phe Asn Glu Pro Gly  Tyr Glu Arg 
    4700                 4705                 4710             


Ser Arg  Gly Thr Pro Ser Gly  Thr Gln Ser Ser Arg  Glu Tyr Asp 
    4715                 4720                 4725             


Gly Asn  Ile Arg Gln Ala Thr  Val Lys Trp Ala Met  Leu Glu Gln 
    4730                 4735                 4740             


Ile Arg  Asn Pro Ser Pro Cys  Phe Lys Glu Val Ile  His Lys His 
    4745                 4750                 4755             


Phe Tyr  Leu Lys Arg Val Glu  Ile Met Ala Gln Cys  Glu Glu Trp 
    4760                 4765                 4770             


Ile Ala  Asp Ile Gln Gln Tyr  Ser Ser Asp Lys Arg  Val Gly Arg 
    4775                 4780                 4785             


Thr Met  Ser His His Ala Ala  Ala Leu Lys Arg His  Thr Ala Gln 
    4790                 4795                 4800             


Leu Arg  Glu Glu Leu Leu Lys  Leu Pro Cys Pro Glu  Gly Leu Asp 
    4805                 4810                 4815             


Pro Asp  Thr Asp Asp Ala Pro  Glu Val Cys Arg Ala  Thr Thr Gly 
    4820                 4825                 4830             


Ala Glu  Glu Thr Leu Met His  Asp Gln Val Lys Pro  Ser Ser Ser 
    4835                 4840                 4845             


Lys Glu  Leu Pro Ser Asp Phe  Gln Leu 
    4850                 4855         


<210>  1164
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIRC7__Homo_sapiens__NP_071444

<400>  1164

Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Thr Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Thr Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Thr Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Thr Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Ala Arg Asp Val Glu Ala Gln 
    210                 215                 220                 


Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu Asp Arg 
225                 230                 235                 240 


Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys Ala Glu 
                245                 250                 255     


Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro Val Arg 
            260                 265                 270         


Ser Arg Val Arg Thr Phe Leu Ser 
        275                 280 


<210>  1165
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIVM__Homo_sapiens__NP_001153068

<400>  1165

Met Gly Ala Gly Asn Leu Pro Pro Ile Thr Gln Glu Glu Ala Leu His 
1               5                   10                  15      


Ile Leu Gly Phe Gln Pro Pro Phe Glu Asp Ile Arg Phe Gly Pro Phe 
            20                  25                  30          


Thr Gly Asn Thr Thr Leu Met Arg Trp Phe Arg Gln Ile Asn Asp His 
        35                  40                  45              


Phe His Val Lys Gly Cys Ser Tyr Val Leu Tyr Lys Pro His Gly Lys 
    50                  55                  60                  


Asn Lys Thr Ala Gly Glu Thr Ala Ser Gly Ala Leu Ser Lys Leu Thr 
65                  70                  75                  80  


Arg Gly Leu Lys Asp Glu Ser Leu Ala Tyr Ile Tyr His Cys Gln Asn 
                85                  90                  95      


His Tyr Phe Cys Pro Ile Gly Phe Glu Ala Thr Pro Val Lys Ala Asn 
            100                 105                 110         


Lys Ala Phe Ser Arg Gly Pro Leu Ser Pro Gln Glu Val Glu Tyr Trp 
        115                 120                 125             


Ile Leu Ile Gly Glu Ser Ser Arg Lys His Pro Ala Ile His Cys Lys 
    130                 135                 140                 


Lys Trp Ala Asp Ile Val Thr Asp Leu Asn Thr Gln Asn Pro Glu Tyr 
145                 150                 155                 160 


Leu Asp Ile Arg His Leu Glu Arg Gly Leu Gln Tyr Arg Lys Thr Lys 
                165                 170                 175     


Lys Pro Thr Phe Phe Ser Ser Gln Val Gly Gly Asn Leu His Cys Ile 
            180                 185                 190         


Ile Ala Phe Gln Arg Leu Asn Trp Gln Arg Phe Gly Leu Trp Asn Phe 
        195                 200                 205             


Pro Phe Gly Thr Ile Arg Gln Glu Ser Gln Pro Pro Thr His Ala Gln 
    210                 215                 220                 


Gly Ile Ala Lys Ser Glu Ser Glu Asp Asn Ile Ser Lys Lys Gln His 
225                 230                 235                 240 


Gly Arg Leu Gly Arg Ser Phe Ser Ala Ser Phe His Gln Asp Ser Ala 
                245                 250                 255     


Trp Lys Lys Met Ser Ser Ile His Glu Arg Arg Asn Ser Gly Tyr Gln 
            260                 265                 270         


Gly Tyr Ser Asp Tyr Asp Gly Asn Asp 
        275                 280     


<210>  1166
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLCAP__Homo_sapiens__NP_001161292

<400>  1166

Met Tyr Cys Leu Gln Trp Leu Leu Pro Val Leu Leu Ile Pro Lys Pro 
1               5                   10                  15      


Leu Asn Pro Ala Leu Trp Phe Ser His Ser Met Phe Met Gly Phe Tyr 
            20                  25                  30          


Leu Leu Ser Phe Leu Leu Glu Arg Lys Pro Cys Thr Ile Cys Ala Leu 
        35                  40                  45              


Val Phe Leu Ala Ala Leu Phe Leu Ile Cys Tyr Ser Cys Trp Gly Asn 
    50                  55                  60                  


Cys Phe Leu Tyr His Cys Ser Asp Ser Pro Leu Pro Glu Ser Ala His 
65                  70                  75                  80  


Asp Pro Gly Val Val Gly Thr 
                85          


<210>  1167
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLID__Homo_sapiens__NP_001001786

<400>  1167

Met Val Thr Leu Leu Pro Ile Glu Gly Gln Glu Ile His Phe Phe Glu 
1               5                   10                  15      


Ile Leu Glu Ser Glu Cys Val Leu Tyr Thr Gly Trp Ile Glu Arg Ala 
            20                  25                  30          


Ser Gly Ser Ser Ile Tyr Pro Glu Ala Lys Ala Arg Leu Pro Leu Glu 
        35                  40                  45              


Ala Leu Leu Gly Ser Asn Lys Glu Pro Met Leu Pro Lys Glu Thr Val 
    50                  55                  60                  


Leu Ser Leu Lys Arg Tyr Asn Leu Gly Ser Ser Ala Met Lys Arg Asn 
65                  70                  75                  80  


Val Pro Gly His Val Leu Gln Arg Pro Ser Tyr Leu Thr Arg Ile Gln 
                85                  90                  95      


Val Thr Leu Leu Cys Asn Ser Ser Ala Glu Ala Leu 
            100                 105             


<210>  1168
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLK__Homo_sapiens__NP_001706

<400>  1168

Met Gly Leu Val Ser Ser Lys Lys Pro Asp Lys Glu Lys Pro Ile Lys 
1               5                   10                  15      


Glu Lys Asp Lys Gly Gln Trp Ser Pro Leu Lys Val Ser Ala Gln Asp 
            20                  25                  30          


Lys Asp Ala Pro Pro Leu Pro Pro Leu Val Val Phe Asn His Leu Thr 
        35                  40                  45              


Pro Pro Pro Pro Asp Glu His Leu Asp Glu Asp Lys His Phe Val Val 
    50                  55                  60                  


Ala Leu Tyr Asp Tyr Thr Ala Met Asn Asp Arg Asp Leu Gln Met Leu 
65                  70                  75                  80  


Lys Gly Glu Lys Leu Gln Val Leu Lys Gly Thr Gly Asp Trp Trp Leu 
                85                  90                  95      


Ala Arg Ser Leu Val Thr Gly Arg Glu Gly Tyr Val Pro Ser Asn Phe 
            100                 105                 110         


Val Ala Arg Val Glu Ser Leu Glu Met Glu Arg Trp Phe Phe Arg Ser 
        115                 120                 125             


Gln Gly Arg Lys Glu Ala Glu Arg Gln Leu Leu Ala Pro Ile Asn Lys 
    130                 135                 140                 


Ala Gly Ser Phe Leu Ile Arg Glu Ser Glu Thr Asn Lys Gly Ala Phe 
145                 150                 155                 160 


Ser Leu Ser Val Lys Asp Val Thr Thr Gln Gly Glu Leu Ile Lys His 
                165                 170                 175     


Tyr Lys Ile Arg Cys Leu Asp Glu Gly Gly Tyr Tyr Ile Ser Pro Arg 
            180                 185                 190         


Ile Thr Phe Pro Ser Leu Gln Ala Leu Val Gln His Tyr Ser Lys Lys 
        195                 200                 205             


Gly Asp Gly Leu Cys Gln Arg Leu Thr Leu Pro Cys Val Arg Pro Ala 
    210                 215                 220                 


Pro Gln Asn Pro Trp Ala Gln Asp Glu Trp Glu Ile Pro Arg Gln Ser 
225                 230                 235                 240 


Leu Arg Leu Val Arg Lys Leu Gly Ser Gly Gln Phe Gly Glu Val Trp 
                245                 250                 255     


Met Gly Tyr Tyr Lys Asn Asn Met Lys Val Ala Ile Lys Thr Leu Lys 
            260                 265                 270         


Glu Gly Thr Met Ser Pro Glu Ala Phe Leu Gly Glu Ala Asn Val Met 
        275                 280                 285             


Lys Ala Leu Gln His Glu Arg Leu Val Arg Leu Tyr Ala Val Val Thr 
    290                 295                 300                 


Lys Glu Pro Ile Tyr Ile Val Thr Glu Tyr Met Ala Arg Gly Cys Leu 
305                 310                 315                 320 


Leu Asp Phe Leu Lys Thr Asp Glu Gly Ser Arg Leu Ser Leu Pro Arg 
                325                 330                 335     


Leu Ile Asp Met Ser Ala Gln Ile Ala Glu Gly Met Ala Tyr Ile Glu 
            340                 345                 350         


Arg Met Asn Ser Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val 
        355                 360                 365             


Ser Glu Ala Leu Cys Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Ile 
    370                 375                 380                 


Ile Asp Ser Glu Tyr Thr Ala Gln Glu Gly Ala Lys Phe Pro Ile Lys 
385                 390                 395                 400 


Trp Thr Ala Pro Glu Ala Ile His Phe Gly Val Phe Thr Ile Lys Ala 
                405                 410                 415     


Asp Val Trp Ser Phe Gly Val Leu Leu Met Glu Val Val Thr Tyr Gly 
            420                 425                 430         


Arg Val Pro Tyr Pro Gly Met Ser Asn Pro Glu Val Ile Arg Asn Leu 
        435                 440                 445             


Glu Arg Gly Tyr Arg Met Pro Arg Pro Asp Thr Cys Pro Pro Glu Leu 
    450                 455                 460                 


Tyr Arg Gly Val Ile Ala Glu Cys Trp Arg Ser Arg Pro Glu Glu Arg 
465                 470                 475                 480 


Pro Thr Phe Glu Phe Leu Gln Ser Val Leu Glu Asp Phe Tyr Thr Ala 
                485                 490                 495     


Thr Glu Arg Gln Tyr Glu Leu Gln Pro 
            500                 505 


<210>  1169
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLMH__Homo_sapiens__NP_000377

<400>  1169

Met Ser Ser Ser Gly Leu Asn Ser Glu Lys Val Ala Ala Leu Ile Gln 
1               5                   10                  15      


Lys Leu Asn Ser Asp Pro Gln Phe Val Leu Ala Gln Asn Val Gly Thr 
            20                  25                  30          


Thr His Asp Leu Leu Asp Ile Cys Leu Lys Arg Ala Thr Val Gln Arg 
        35                  40                  45              


Ala Gln His Val Phe Gln His Ala Val Pro Gln Glu Gly Lys Pro Ile 
    50                  55                  60                  


Thr Asn Gln Lys Ser Ser Gly Arg Cys Trp Ile Phe Ser Cys Leu Asn 
65                  70                  75                  80  


Val Met Arg Leu Pro Phe Met Lys Lys Leu Asn Ile Glu Glu Phe Glu 
                85                  90                  95      


Phe Ser Gln Ser Tyr Leu Phe Phe Trp Asp Lys Val Glu Arg Cys Tyr 
            100                 105                 110         


Phe Phe Leu Ser Ala Phe Val Asp Thr Ala Gln Arg Lys Glu Pro Glu 
        115                 120                 125             


Asp Gly Arg Leu Val Gln Phe Leu Leu Met Asn Pro Ala Asn Asp Gly 
    130                 135                 140                 


Gly Gln Trp Asp Met Leu Val Asn Ile Val Glu Lys Tyr Gly Val Ile 
145                 150                 155                 160 


Pro Lys Lys Cys Phe Pro Glu Ser Tyr Thr Thr Glu Ala Thr Arg Arg 
                165                 170                 175     


Met Asn Asp Ile Leu Asn His Lys Met Arg Glu Phe Cys Ile Arg Leu 
            180                 185                 190         


Arg Asn Leu Val His Ser Gly Ala Thr Lys Gly Glu Ile Ser Ala Thr 
        195                 200                 205             


Gln Asp Val Met Met Glu Glu Ile Phe Arg Val Val Cys Ile Cys Leu 
    210                 215                 220                 


Gly Asn Pro Pro Glu Thr Phe Thr Trp Glu Tyr Arg Asp Lys Asp Lys 
225                 230                 235                 240 


Asn Tyr Gln Lys Ile Gly Pro Ile Thr Pro Leu Glu Phe Tyr Arg Glu 
                245                 250                 255     


His Val Lys Pro Leu Phe Asn Met Glu Asp Lys Ile Cys Leu Val Asn 
            260                 265                 270         


Asp Pro Arg Pro Gln His Lys Tyr Asn Lys Leu Tyr Thr Val Glu Tyr 
        275                 280                 285             


Leu Ser Asn Met Val Gly Gly Arg Lys Thr Leu Tyr Asn Asn Gln Pro 
    290                 295                 300                 


Ile Asp Phe Leu Lys Lys Met Val Ala Ala Ser Ile Lys Asp Gly Glu 
305                 310                 315                 320 


Ala Val Trp Phe Gly Cys Asp Val Gly Lys His Phe Asn Ser Lys Leu 
                325                 330                 335     


Gly Leu Ser Asp Met Asn Leu Tyr Asp His Glu Leu Val Phe Gly Val 
            340                 345                 350         


Ser Leu Lys Asn Met Asn Lys Ala Glu Arg Leu Thr Phe Gly Glu Ser 
        355                 360                 365             


Leu Met Thr His Ala Met Thr Phe Thr Ala Val Ser Glu Lys Asp Asp 
    370                 375                 380                 


Gln Asp Gly Ala Phe Thr Lys Trp Arg Val Glu Asn Ser Trp Gly Glu 
385                 390                 395                 400 


Asp His Gly His Lys Gly Tyr Leu Cys Met Thr Asp Glu Trp Phe Ser 
                405                 410                 415     


Glu Tyr Val Tyr Glu Val Val Val Asp Arg Lys His Val Pro Glu Glu 
            420                 425                 430         


Val Leu Ala Val Leu Glu Gln Glu Pro Ile Ile Leu Pro Ala Trp Asp 
        435                 440                 445             


Pro Met Gly Ala Leu Ala Glu 
    450                 455 


<210>  1170
<211>  1417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLM__Homo_sapiens__NP_001274175

<400>  1170

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210>  1171
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLNK__Homo_sapiens__NP_001107566

<400>  1171

Met Asp Lys Leu Asn Lys Ile Thr Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Thr Glu Ser Ser Ser Pro Pro Pro Glu Lys Gly Arg Asn Ser Gly Ala 
        195                 200                 205             


Trp Glu Thr Lys Ser Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro Arg 
    210                 215                 220                 


Ala Gly Lys Lys Pro Thr Thr Pro Leu Lys Thr Thr Pro Val Ala Ser 
225                 230                 235                 240 


Gln Gln Asn Ala Ser Ser Val Cys Glu Glu Lys Pro Ile Pro Ala Glu 
                245                 250                 255     


Arg His Arg Gly Ser Ser His Arg Gln Glu Ala Val Gln Ser Pro Val 
            260                 265                 270         


Phe Pro Pro Ala Gln Lys Gln Ile His Gln Lys Pro Ile Pro Leu Pro 
        275                 280                 285             


Arg Phe Thr Glu Gly Gly Asn Pro Thr Val Asp Gly Pro Leu Pro Ser 
    290                 295                 300                 


Phe Ser Ser Asn Ser Thr Ile Ser Glu Gln Glu Ala Gly Val Leu Cys 
305                 310                 315                 320 


Lys Pro Trp Tyr Ala Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu Ala 
                325                 330                 335     


Leu His Arg Ser Asn Lys Asp Gly Ser Phe Leu Ile Arg Lys Ser Ser 
            340                 345                 350         


Gly His Asp Ser Lys Gln Pro Tyr Thr Leu Val Val Phe Phe Asn Lys 
        355                 360                 365             


Arg Val Tyr Asn Ile Pro Val Arg Phe Ile Glu Ala Thr Lys Gln Tyr 
    370                 375                 380                 


Ala Leu Gly Arg Lys Lys Asn Gly Glu Glu Tyr Phe Gly Ser Val Ala 
385                 390                 395                 400 


Glu Ile Ile Arg Asn His Gln His Ser Pro Leu Val Leu Ile Asp Ser 
                405                 410                 415     


Gln Asn Asn Thr Lys Asp Ser Thr Arg Leu Lys Tyr Ala Val Lys Val 
            420                 425                 430         


Ser 
    


<210>  1172
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLOC1S2__Homo_sapiens__NP_001269365

<400>  1172

Met Arg Leu Pro Arg Lys Ser Leu Glu Val Ala Thr Ser Glu Asp Tyr 
1               5                   10                  15      


Lys Leu Leu Glu Asn Met Asn Lys Leu Thr Ser Leu Lys Tyr Leu Glu 
            20                  25                  30          


Met Lys Asp Ile Ala Ile Asn Ile Ser Arg Asn Leu Lys Asp Leu Asn 
        35                  40                  45              


Gln Lys Tyr Ala Gly Leu Gln Pro Tyr Leu Asp Gln Ile Asn Val Ile 
    50                  55                  60                  


Glu Glu Gln Val Ala Ala Leu Glu Gln Ala Ala Tyr Lys Leu Asp Ala 
65                  70                  75                  80  


Tyr Ser Lys Lys Leu Glu Ala Lys Tyr Lys Lys Leu Glu Lys Arg 
                85                  90                  95  


<210>  1173
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLOC1S3__Homo_sapiens__NP_997715

<400>  1173

Met Ala Ser Gln Gly Arg Arg Arg Arg Pro Leu Arg Arg Pro Glu Thr 
1               5                   10                  15      


Val Val Pro Gly Glu Ala Thr Glu Thr Asp Ser Glu Arg Ser Ala Ser 
            20                  25                  30          


Ser Ser Glu Glu Glu Glu Leu Tyr Leu Gly Pro Ser Gly Pro Thr Arg 
        35                  40                  45              


Gly Arg Pro Thr Gly Leu Arg Val Ala Gly Glu Ala Ala Glu Thr Asp 
    50                  55                  60                  


Ser Glu Pro Glu Pro Glu Pro Glu Pro Thr Ala Ala Pro Arg Asp Leu 
65                  70                  75                  80  


Pro Pro Leu Val Val Gln Arg Glu Ser Ala Glu Glu Ala Trp Gly Thr 
                85                  90                  95      


Glu Glu Ala Pro Ala Pro Ala Pro Ala Arg Ser Leu Leu Gln Leu Arg 
            100                 105                 110         


Leu Ala Glu Ser Gln Ala Arg Leu Asp His Asp Val Ala Ala Ala Val 
        115                 120                 125             


Ser Gly Val Tyr Arg Arg Ala Gly Arg Asp Val Ala Ala Leu Ala Ser 
    130                 135                 140                 


Arg Leu Ala Ala Ala Gln Ala Ala Gly Leu Ala Ala Ala His Ser Val 
145                 150                 155                 160 


Arg Leu Ala Arg Gly Asp Leu Cys Ala Leu Ala Glu Arg Leu Asp Ile 
                165                 170                 175     


Val Ala Gly Cys Arg Leu Leu Pro Asp Ile Arg Gly Val Pro Gly Thr 
            180                 185                 190         


Glu Pro Glu Lys Asp Pro Gly Pro Arg Ala 
        195                 200         


<210>  1174
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLOC1S4__Homo_sapiens__NP_060836

<400>  1174

Met Glu Gly Ser Phe Ser Asp Gly Gly Ala Leu Pro Glu Gly Leu Ala 
1               5                   10                  15      


Glu Glu Ala Glu Pro Gln Gly Ala Ala Trp Ser Gly Asp Ser Gly Thr 
            20                  25                  30          


Val Ser Gln Ser His Ser Ser Ala Ser Gly Pro Trp Glu Asp Glu Gly 
        35                  40                  45              


Ala Glu Asp Gly Ala Pro Gly Arg Asp Leu Pro Leu Leu Arg Arg Ala 
    50                  55                  60                  


Ala Ala Gly Tyr Ala Ala Cys Leu Leu Pro Gly Ala Gly Ala Arg Pro 
65                  70                  75                  80  


Glu Val Glu Ala Leu Asp Ala Ser Leu Glu Asp Leu Leu Thr Arg Val 
                85                  90                  95      


Asp Glu Phe Val Gly Met Leu Asp Met Leu Arg Gly Asp Ser Ser His 
            100                 105                 110         


Val Val Ser Glu Gly Val Pro Arg Ile His Ala Lys Ala Ala Glu Met 
        115                 120                 125             


Arg Arg Ile Tyr Ser Arg Ile Asp Arg Leu Glu Ala Phe Val Arg Met 
    130                 135                 140                 


Val Gly Gly Arg Val Ala Arg Met Glu Glu Gln Val Thr Lys Ala Glu 
145                 150                 155                 160 


Ala Glu Leu Gly Thr Phe Pro Arg Ala Phe Lys Lys Leu Leu His Thr 
                165                 170                 175     


Met Asn Val Pro Ser Leu Phe Ser Lys Ser Ala Pro Ser Arg Pro Gln 
            180                 185                 190         


Gln Ala Gly Tyr Glu Ala Pro Val Leu Phe Arg Thr Glu Asp Tyr Phe 
        195                 200                 205             


Pro Cys Cys Ser Glu Arg Pro Gln Leu 
    210                 215         


<210>  1175
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLOC1S5__Homo_sapiens__NP_001186251

<400>  1175

Met Glu Lys Arg Gly Leu Arg Glu Met Arg Val Leu Glu Asn Leu Lys 
1               5                   10                  15      


Asn Met Ile His Glu Thr Asn Glu His Thr Leu Pro Lys Cys Arg Asp 
            20                  25                  30          


Thr Met Arg Asp Ser Leu Ser Gln Val Leu Gln Arg Leu Gln Ala Ala 
        35                  40                  45              


Asn Asp Ser Val Cys Arg Leu Gln Gln Arg Glu Gln Glu Arg Lys Lys 
    50                  55                  60                  


Ile His Ser Asp His Leu Val Ala Ser Glu Lys Gln His Met Leu Gln 
65                  70                  75                  80  


Trp Asp Asn Phe Met Lys Glu Gln Pro Asn Lys Arg Ala Glu Val Asp 
                85                  90                  95      


Glu Glu His Arg Lys Ala Met Glu Arg Leu Lys Glu Gln Tyr Ala Glu 
            100                 105                 110         


Met Glu Lys Asp Leu Ala Lys Phe Ser Thr Phe 
        115                 120             


<210>  1176
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLOC1S6__Homo_sapiens__NP_036520

<400>  1176

Met Ser Val Pro Gly Pro Ser Ser Pro Asp Gly Ala Leu Thr Arg Pro 
1               5                   10                  15      


Pro Tyr Cys Leu Glu Ala Gly Glu Pro Thr Pro Gly Leu Ser Asp Thr 
            20                  25                  30          


Ser Pro Asp Glu Gly Leu Ile Glu Asp Leu Thr Ile Glu Asp Lys Ala 
        35                  40                  45              


Val Glu Gln Leu Ala Glu Gly Leu Leu Ser His Tyr Leu Pro Asp Leu 
    50                  55                  60                  


Gln Arg Ser Lys Gln Ala Leu Gln Glu Leu Thr Gln Asn Gln Val Val 
65                  70                  75                  80  


Leu Leu Asp Thr Leu Glu Gln Glu Ile Ser Lys Phe Lys Glu Cys His 
                85                  90                  95      


Ser Met Leu Asp Ile Asn Ala Leu Phe Ala Glu Ala Lys His Tyr His 
            100                 105                 110         


Ala Lys Leu Val Asn Ile Arg Lys Glu Met Leu Met Leu His Glu Lys 
        115                 120                 125             


Thr Ser Lys Leu Lys Lys Arg Ala Leu Lys Leu Gln Gln Lys Arg Gln 
    130                 135                 140                 


Lys Glu Glu Leu Glu Arg Glu Gln Gln Arg Glu Lys Glu Phe Glu Arg 
145                 150                 155                 160 


Glu Lys Gln Leu Thr Ala Arg Pro Ala Lys Arg Met 
                165                 170         


<210>  1177
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLVRA__Homo_sapiens__XP_011513776

<400>  1177

Met Asn Ala Glu Pro Glu Arg Lys Phe Gly Val Val Val Val Gly Val 
1               5                   10                  15      


Gly Arg Ala Gly Ser Val Arg Met Arg Asp Leu Arg Asn Pro His Pro 
            20                  25                  30          


Ser Ser Ala Phe Leu Asn Leu Ile Gly Phe Val Ser Arg Arg Glu Leu 
        35                  40                  45              


Gly Ser Ile Asp Gly Val Gln Gln Ile Ser Leu Glu Asp Ala Leu Ser 
    50                  55                  60                  


Ser Gln Glu Val Glu Val Ala Tyr Ile Cys Ser Glu Ser Ser Ser His 
65                  70                  75                  80  


Glu Asp Tyr Ile Arg Gln Phe Leu Asn Ala Gly Lys His Val Leu Val 
                85                  90                  95      


Glu Tyr Pro Met Thr Leu Ser Leu Ala Ala Ala Gln Glu Leu Trp Glu 
            100                 105                 110         


Leu Ala Glu Gln Lys Gly Lys Val Leu His Glu Glu His Val Glu Leu 
        115                 120                 125             


Leu Met Glu Glu Phe Ala Phe Leu Lys Lys Glu Val Val Gly Lys Asp 
    130                 135                 140                 


Leu Leu Lys Gly Ser Leu Leu Phe Thr Ala Gly Pro Leu Glu Glu Glu 
145                 150                 155                 160 


Arg Phe Gly Phe Pro Ala Phe Ser Gly Ile Ser Arg Leu Thr Trp Leu 
                165                 170                 175     


Val Ser Leu Phe Gly Glu Leu Ser Leu Val Ser Ala Thr Leu Glu Glu 
            180                 185                 190         


Arg Lys Glu Asp Gln Tyr Met Lys Met Thr Val Cys Leu Glu Thr Glu 
        195                 200                 205             


Lys Lys Ser Pro Leu Ser Trp Ile Glu Glu Lys Gly Pro Gly Leu Lys 
    210                 215                 220                 


Arg Asn Arg Tyr Leu Ser Phe His Phe Lys Ser Gly Ser Leu Glu Asn 
225                 230                 235                 240 


Val Pro Asn Val Gly Val Asn Lys Asn Ile Phe Leu Lys Asp Gln Asn 
                245                 250                 255     


Ile Phe Val Gln Lys Leu Leu Gly Gln Phe Ser Glu Lys Glu Leu Ala 
            260                 265                 270         


Ala Glu Lys Lys Arg Ile Leu His Cys Leu Gly Leu Ala Glu Glu Ile 
        275                 280                 285             


Gln Lys Tyr Cys Cys Ser Arg Lys 
    290                 295     


<210>  1178
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLVRB__Homo_sapiens__NP_000704

<400>  1178

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala 
            100                 105                 110         


Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val 
        115                 120                 125             


Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu 
    130                 135                 140                 


Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr 
145                 150                 155                 160 


Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile 
                165                 170                 175     


Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp 
            180                 185                 190         


Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln 
        195                 200                 205     


<210>  1179
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLZF1__Homo_sapiens__NP_003657

<400>  1179

Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro 
1               5                   10                  15      


Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser 
            20                  25                  30          


Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln 
        35                  40                  45              


Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln 
    50                  55                  60                  


Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg 
65                  70                  75                  80  


Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn 
                85                  90                  95      


Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln 
            100                 105                 110         


Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn 
        115                 120                 125             


Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys 
    130                 135                 140                 


Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His 
                165                 170                 175     


Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu 
            180                 185                 190         


Ala Leu Gly Arg Asn Thr Ala Gln Leu Ser Glu Gln Leu Glu Arg Met 
        195                 200                 205             


Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val 
    210                 215                 220                 


Met Ala Asp Glu Leu Thr Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn 
225                 230                 235                 240 


Arg Asp Ala His Gly Ala Ile Gln Asp Leu Leu Ser Glu Arg Glu Gln 
                245                 250                 255     


Phe Arg Gln Glu Met Ile Ala Thr Gln Lys Leu Leu Glu Glu Leu Leu 
            260                 265                 270         


Val Ser Leu Gln Trp Gly Arg Glu Gln Thr Tyr Ser Pro Ser Val Gln 
        275                 280                 285             


Pro His Ser Thr Ala Glu Leu Ala Leu Thr Asn His Lys Leu Ala Lys 
    290                 295                 300                 


Ala Val Asn Ser His Leu Leu Gly Asn Val Gly Ile Asn Asn Gln Lys 
305                 310                 315                 320 


Lys Ile Pro Ser Thr Val Glu Phe Cys Ser Thr Pro Ala Glu Lys Met 
                325                 330                 335     


Ala Glu Thr Val Leu Arg Ile Leu Asp Pro Val Thr Cys Lys Glu Ser 
            340                 345                 350         


Ser Pro Asp Asn Pro Phe Phe Glu Ser Ser Pro Thr Thr Leu Leu Ala 
        355                 360                 365             


Thr Lys Lys Asn Ile Gly Arg Phe His Pro Tyr Thr Arg Tyr Glu Asn 
    370                 375                 380                 


Ile Thr Phe Asn Cys Cys Asn His Cys Arg Gly Glu Leu Ile Ala Leu 
385                 390                 395                 400 


<210>  1180
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMF__Homo_sapiens__NP_001003942

<400>  1180

Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln 
1               5                   10                  15      


Pro Glu Asp Gly Glu Pro Val Thr Gln Pro Gly Ser Leu Leu Ser Ala 
            20                  25                  30          


Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln 
        35                  40                  45              


Leu Phe Pro Leu Thr His Cys Cys Gly Pro Gly Leu Arg Pro Thr Ser 
    50                  55                  60                  


Gln Glu Asp Lys Ala Thr Gln Thr Leu Ser Pro Ala Ser Pro Ser Gln 
65                  70                  75                  80  


Gly Val Met Leu Pro Cys Gly Val Thr Glu Glu Pro Gln Arg Leu Phe 
                85                  90                  95      


Tyr Gly Asn Ala Gly Tyr Arg Leu Pro Leu Pro Ala Ser Phe Pro Ala 
            100                 105                 110         


Val Leu Pro Ile Gly Glu Gln Pro Pro Glu Gly Gln Trp Gln His Gln 
        115                 120                 125             


Ala Glu His Gln Gln Asn Gln Asn Arg Val Trp Trp Gln Ile Leu Leu 
    130                 135                 140                 


Phe Leu His Asn Leu Ala Leu Asn Gly Glu Glu Asn Arg Asn Gly Ala 
145                 150                 155                 160 


Gly Pro Arg 
            


<210>  1181
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMI1__Homo_sapiens__NP_005171

<400>  1181

Met His Arg Thr Thr Arg Ile Lys Ile Thr Glu Leu Asn Pro His Leu 
1               5                   10                  15      


Met Cys Val Leu Cys Gly Gly Tyr Phe Ile Asp Ala Thr Thr Ile Ile 
            20                  25                  30          


Glu Cys Leu His Ser Phe Cys Lys Thr Cys Ile Val Arg Tyr Leu Glu 
        35                  40                  45              


Thr Ser Lys Tyr Cys Pro Ile Cys Asp Val Gln Val His Lys Thr Arg 
    50                  55                  60                  


Pro Leu Leu Asn Ile Arg Ser Asp Lys Thr Leu Gln Asp Ile Val Tyr 
65                  70                  75                  80  


Lys Leu Val Pro Gly Leu Phe Lys Asn Glu Met Lys Arg Arg Arg Asp 
                85                  90                  95      


Phe Tyr Ala Ala His Pro Ser Ala Asp Ala Ala Asn Gly Ser Asn Glu 
            100                 105                 110         


Asp Arg Gly Glu Val Ala Asp Glu Asp Lys Arg Ile Ile Thr Asp Asp 
        115                 120                 125             


Glu Ile Ile Ser Leu Ser Ile Glu Phe Phe Asp Gln Asn Arg Leu Asp 
    130                 135                 140                 


Arg Lys Val Asn Lys Asp Lys Glu Lys Ser Lys Glu Glu Val Asn Asp 
145                 150                 155                 160 


Lys Arg Tyr Leu Arg Cys Pro Ala Ala Met Thr Val Met His Leu Arg 
                165                 170                 175     


Lys Phe Leu Arg Ser Lys Met Asp Ile Pro Asn Thr Phe Gln Ile Asp 
            180                 185                 190         


Val Met Tyr Glu Glu Glu Pro Leu Lys Asp Tyr Tyr Thr Leu Met Asp 
        195                 200                 205             


Ile Ala Tyr Ile Tyr Thr Trp Arg Arg Asn Gly Pro Leu Pro Leu Lys 
    210                 215                 220                 


Tyr Arg Val Arg Pro Thr Cys Lys Arg Met Lys Ile Ser His Gln Arg 
225                 230                 235                 240 


Asp Gly Leu Thr Asn Ala Gly Glu Leu Glu Ser Asp Ser Gly Ser Asp 
                245                 250                 255     


Lys Ala Asn Ser Pro Ala Gly Gly Ile Pro Ser Thr Ser Ser Cys Leu 
            260                 265                 270         


Pro Ser Pro Ser Thr Pro Val Gln Ser Pro His Pro Gln Phe Pro His 
        275                 280                 285             


Ile Ser Ser Thr Met Asn Gly Thr Ser Asn Ser Pro Ser Gly Asn His 
    290                 295                 300                 


Gln Ser Ser Phe Ala Asn Arg Pro Arg Lys Ser Ser Val Asn Gly Ser 
305                 310                 315                 320 


Ser Ala Thr Ser Ser Gly 
                325     


<210>  1182
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP10__Homo_sapiens__NP_055297

<400>  1182

Met Gly Ser Leu Val Leu Thr Leu Cys Ala Leu Phe Cys Leu Ala Ala 
1               5                   10                  15      


Tyr Leu Val Ser Gly Ser Pro Ile Met Asn Leu Glu Gln Ser Pro Leu 
            20                  25                  30          


Glu Glu Asp Met Ser Leu Phe Gly Asp Val Phe Ser Glu Gln Asp Gly 
        35                  40                  45              


Val Asp Phe Asn Thr Leu Leu Gln Ser Met Lys Asp Glu Phe Leu Lys 
    50                  55                  60                  


Thr Leu Asn Leu Ser Asp Ile Pro Thr Gln Asp Ser Ala Lys Val Asp 
65                  70                  75                  80  


Pro Pro Glu Tyr Met Leu Glu Leu Tyr Asn Lys Phe Ala Thr Asp Arg 
                85                  90                  95      


Thr Ser Met Pro Ser Ala Asn Ile Ile Arg Ser Phe Lys Asn Glu Asp 
            100                 105                 110         


Leu Phe Ser Gln Pro Val Ser Phe Asn Gly Leu Arg Lys Tyr Pro Leu 
        115                 120                 125             


Leu Phe Asn Val Ser Ile Pro His His Glu Glu Val Ile Met Ala Glu 
    130                 135                 140                 


Leu Arg Leu Tyr Thr Leu Val Gln Arg Asp Arg Met Ile Tyr Asp Gly 
145                 150                 155                 160 


Val Asp Arg Lys Ile Thr Ile Phe Glu Val Leu Glu Ser Lys Gly Asp 
                165                 170                 175     


Asn Glu Gly Glu Arg Asn Met Leu Val Leu Val Ser Gly Glu Ile Tyr 
            180                 185                 190         


Gly Thr Asn Ser Glu Trp Glu Thr Phe Asp Val Thr Asp Ala Ile Arg 
        195                 200                 205             


Arg Trp Gln Lys Ser Gly Ser Ser Thr His Gln Leu Glu Val His Ile 
    210                 215                 220                 


Glu Ser Lys His Asp Glu Ala Glu Asp Ala Ser Ser Gly Arg Leu Glu 
225                 230                 235                 240 


Ile Asp Thr Ser Ala Gln Asn Lys His Asn Pro Leu Leu Ile Val Phe 
                245                 250                 255     


Ser Asp Asp Gln Ser Ser Asp Lys Glu Arg Lys Glu Glu Leu Asn Glu 
            260                 265                 270         


Met Ile Ser His Glu Gln Leu Pro Glu Leu Asp Asn Leu Gly Leu Asp 
        275                 280                 285             


Ser Phe Ser Ser Gly Pro Gly Glu Glu Ala Leu Leu Gln Met Arg Ser 
    290                 295                 300                 


Asn Ile Ile Tyr Asp Ser Thr Ala Arg Ile Arg Arg Asn Ala Lys Gly 
305                 310                 315                 320 


Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe Lys Glu Ile Gly 
                325                 330                 335     


Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu Cys 
            340                 345                 350         


Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu Thr Pro Thr Lys 
        355                 360                 365             


His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn Ser Gln Lys Ala 
    370                 375                 380                 


Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro Ile Ser Ile Leu 
385                 390                 395                 400 


Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met 
                405                 410                 415     


Ala Val Ser Glu Cys Gly Cys Arg 
            420                 


<210>  1183
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP15__Homo_sapiens__NP_005439

<400>  1183

Met Val Leu Leu Ser Ile Leu Arg Ile Leu Phe Leu Cys Glu Leu Val 
1               5                   10                  15      


Leu Phe Met Glu His Arg Ala Gln Met Ala Glu Gly Gly Gln Ser Ser 
            20                  25                  30          


Ile Ala Leu Leu Ala Glu Ala Pro Thr Leu Pro Leu Ile Glu Glu Leu 
        35                  40                  45              


Leu Glu Glu Ser Pro Gly Glu Gln Pro Arg Lys Pro Arg Leu Leu Gly 
    50                  55                  60                  


His Ser Leu Arg Tyr Met Leu Glu Leu Tyr Arg Arg Ser Ala Asp Ser 
65                  70                  75                  80  


His Gly His Pro Arg Glu Asn Arg Thr Ile Gly Ala Thr Met Val Arg 
                85                  90                  95      


Leu Val Lys Pro Leu Thr Asn Val Ala Arg Pro His Arg Gly Thr Trp 
            100                 105                 110         


His Ile Gln Ile Leu Gly Phe Pro Leu Arg Pro Asn Arg Gly Leu Tyr 
        115                 120                 125             


Gln Leu Val Arg Ala Thr Val Val Tyr Arg His His Leu Gln Leu Thr 
    130                 135                 140                 


Arg Phe Asn Leu Ser Cys His Val Glu Pro Trp Val Gln Lys Asn Pro 
145                 150                 155                 160 


Thr Asn His Phe Pro Ser Ser Glu Gly Asp Ser Ser Lys Pro Ser Leu 
                165                 170                 175     


Met Ser Asn Ala Trp Lys Glu Met Asp Ile Thr Gln Leu Val Gln Gln 
            180                 185                 190         


Arg Phe Trp Asn Asn Lys Gly His Arg Ile Leu Arg Leu Arg Phe Met 
        195                 200                 205             


Cys Gln Gln Gln Lys Asp Ser Gly Gly Leu Glu Leu Trp His Gly Thr 
    210                 215                 220                 


Ser Ser Leu Asp Ile Ala Phe Leu Leu Leu Tyr Phe Asn Asp Thr His 
225                 230                 235                 240 


Lys Ser Ile Arg Lys Ala Lys Phe Leu Pro Arg Gly Met Glu Glu Phe 
                245                 250                 255     


Met Glu Arg Glu Ser Leu Leu Arg Arg Thr Arg Gln Ala Asp Gly Ile 
            260                 265                 270         


Ser Ala Glu Val Thr Ala Ser Ser Ser Lys His Ser Gly Pro Glu Asn 
        275                 280                 285             


Asn Gln Cys Ser Leu His Pro Phe Gln Ile Ser Phe Arg Gln Leu Gly 
    290                 295                 300                 


Trp Asp His Trp Ile Ile Ala Pro Pro Phe Tyr Thr Pro Asn Tyr Cys 
305                 310                 315                 320 


Lys Gly Thr Cys Leu Arg Val Leu Arg Asp Gly Leu Asn Ser Pro Asn 
                325                 330                 335     


His Ala Ile Ile Gln Asn Leu Ile Asn Gln Leu Val Asp Gln Ser Val 
            340                 345                 350         


Pro Arg Pro Ser Cys Val Pro Tyr Lys Tyr Val Pro Ile Ser Val Leu 
        355                 360                 365             


Met Ile Glu Ala Asn Gly Ser Ile Leu Tyr Lys Glu Tyr Glu Gly Met 
    370                 375                 380                 


Ile Ala Glu Ser Cys Thr Cys Arg 
385                 390         


<210>  1184
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP1__Homo_sapiens__NP_001190

<400>  1184

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Glu Lys 
    690                 695                 700                 


Arg Pro Ala Leu Gln Pro Pro Arg Gly Arg Pro His Gln Leu Lys Phe 
705                 710                 715                 720 


Arg Val Gln Lys Arg Asn Arg Thr Pro Gln 
                725                 730 


<210>  1185
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP2__Homo_sapiens__NP_001191

<400>  1185

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  1186
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP2K__Homo_sapiens__NP_060063

<400>  1186

Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys 
            20                  25                  30          


Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg 
        35                  40                  45              


His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr 
    50                  55                  60                  


Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg 
65                  70                  75                  80  


Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile 
                85                  90                  95      


Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu 
            100                 105                 110         


Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile 
        115                 120                 125             


Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys 
    130                 135                 140                 


Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys 
145                 150                 155                 160 


Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile 
                165                 170                 175     


Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly 
            180                 185                 190         


Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn 
        195                 200                 205             


Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr 
    210                 215                 220                 


Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly 
225                 230                 235                 240 


Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu 
                245                 250                 255     


Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala 
            260                 265                 270         


Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg 
        275                 280                 285             


Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His 
    290                 295                 300                 


Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys 
305                 310                 315                 320 


Lys Asp Cys Pro Val Ser Asn Ile Asn Asn Ser Ser Ile Pro Ser Ala 
                325                 330                 335     


Leu Pro Glu Pro Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln 
            340                 345                 350         


Ile Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile 
        355                 360                 365             


Ala Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro 
    370                 375                 380                 


Ser Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala 
385                 390                 395                 400 


Pro Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly 
                405                 410                 415     


Asn Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro 
            420                 425                 430         


Gln Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu 
        435                 440                 445             


Gln Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln 
    450                 455                 460                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
465                 470                 475                 480 


Gln Gln Gln Gln Gln Gln His His His His His His His His Leu Leu 
                485                 490                 495     


Gln Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln 
            500                 505                 510         


Met Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro 
        515                 520                 525             


Ser Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe 
    530                 535                 540                 


Phe Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala 
545                 550                 555                 560 


Ser Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val 
                565                 570                 575     


Ser Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser 
            580                 585                 590         


Ser Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn 
        595                 600                 605             


Phe Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp 
    610                 615                 620                 


Asn Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu 
625                 630                 635                 640 


Leu Asp Arg Glu Phe Asp Leu Leu Arg Ser Ser Lys Gly His Leu Lys 
                645                 650                 655     


Ala Tyr Phe Ala Ser Gln 
            660         


<210>  1187
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP3__Homo_sapiens__XP_006714354

<400>  1187

Met Ala Gly Ala Ser Arg Leu Leu Phe Leu Trp Leu Gly Cys Phe Cys 
1               5                   10                  15      


Val Ser Leu Ala Gln Gly Glu Arg Pro Lys Pro Pro Phe Pro Glu Leu 
            20                  25                  30          


Arg Lys Ala Val Pro Gly Asp Arg Thr Ala Gly Gly Gly Pro Asp Ser 
        35                  40                  45              


Glu Leu Gln Pro Gln Asp Lys Val Ser Glu His Met Leu Arg Leu Tyr 
    50                  55                  60                  


Asp Arg Tyr Ser Thr Val Gln Ala Ala Arg Thr Pro Gly Ser Leu Glu 
65                  70                  75                  80  


Gly Gly Ser Gln Pro Trp Arg Pro Arg Leu Leu Arg Glu Gly Asn Thr 
                85                  90                  95      


Val Arg Ser Phe Arg Ala Ala Ala Ala Glu Thr Leu Glu Arg Lys Gly 
            100                 105                 110         


Leu Tyr Ile Phe Asn Leu Thr Ser Leu Thr Lys Ser Glu Asn Ile Leu 
        115                 120                 125             


Ser Ala Thr Leu Tyr Phe Cys Ile Gly Glu Leu Gly Asn Ile Ser Leu 
    130                 135                 140                 


Ser Cys Pro Val Ser Gly Gly Cys Ser His His Ala Gln Arg Lys His 
145                 150                 155                 160 


Ile Gln Ile Asp Leu Ser Ala Trp Thr Leu Lys Phe Ser Arg Asn Gln 
                165                 170                 175     


Ser Gln Leu Leu Gly His Leu Ser Val Asp Met Ala Lys Ser His Arg 
            180                 185                 190         


Asp Ile Met Ser Trp Leu Ser Lys Asp Ile Thr Gln Leu Leu Arg Lys 
        195                 200                 205             


Ala Lys Glu Asn Glu Glu Phe Leu Ile Gly Phe Asn Ile Thr Ser Lys 
    210                 215                 220                 


Gly Arg Gln Leu Pro Lys Arg Arg Leu Pro Phe Pro Glu Pro Tyr Ile 
225                 230                 235                 240 


Leu Val Tyr Ala Asn Asp Ala Ala Ile Ser Glu Pro Glu Ser Val Val 
                245                 250                 255     


Ser Ser Leu Gln Gly His Arg Asn Phe Pro Thr Gly Thr Val Pro Lys 
            260                 265                 270         


Trp Asp Ser His Ile Arg Ala Ala Leu Ser Ile Glu Arg Arg Lys Lys 
        275                 280                 285             


Arg Ser Thr Gly Val Leu Leu Pro Leu Gln Asn Asn Glu Leu Pro Gly 
    290                 295                 300                 


Ala Glu Tyr Gln Tyr Lys Lys Asp Glu Val Trp Glu Glu Arg Lys Pro 
305                 310                 315                 320 


Tyr Lys Thr Leu Gln Ala Gln Ala Pro Glu Lys Ser Lys Asn Lys Lys 
                325                 330                 335     


Lys Gln Arg Lys Gly Pro His Arg Lys Ser Gln Thr Leu Gln Phe Asp 
            340                 345                 350         


Glu Gln Thr Leu Lys Lys Ala Arg Arg Lys Gln Trp Ile Glu Pro Arg 
        355                 360                 365             


Asn Cys Ala Arg Arg Tyr Leu Lys Ser Leu Lys Pro Ser Asn His Ala 
    370                 375                 380                 


Thr Ile Gln Ser Ile Val Arg Ala Val Gly Val Val Pro Gly Ile Pro 
385                 390                 395                 400 


Glu Pro Cys Cys Val Pro Glu Lys Met Ser Ser Leu Ser Ile Leu Phe 
                405                 410                 415     


Phe Asp Glu Asn Lys Asn Val Val Leu Lys Val Tyr Pro Asn Met Thr 
            420                 425                 430         


Val Glu Ser Cys Ala Cys Arg 
        435                 


<210>  1188
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP4__Homo_sapiens__NP_001193

<400>  1188

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  1189
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP5__Homo_sapiens__NP_066551

<400>  1189

Met His Leu Thr Val Phe Leu Leu Lys Gly Ile Val Gly Phe Leu Trp 
1               5                   10                  15      


Ser Cys Trp Val Leu Val Gly Tyr Ala Lys Gly Gly Leu Gly Asp Asn 
            20                  25                  30          


His Val His Ser Ser Phe Ile Tyr Arg Arg Leu Arg Asn His Glu Arg 
        35                  40                  45              


Arg Glu Ile Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu Pro His Arg 
    50                  55                  60                  


Pro Arg Pro Phe Ser Pro Gly Lys Gln Ala Ser Ser Ala Pro Leu Phe 
65                  70                  75                  80  


Met Leu Asp Leu Tyr Asn Ala Met Thr Asn Glu Glu Asn Pro Glu Glu 
                85                  90                  95      


Ser Glu Tyr Ser Val Arg Ala Ser Leu Ala Glu Glu Thr Arg Gly Ala 
            100                 105                 110         


Arg Lys Gly Tyr Pro Ala Ser Pro Asn Gly Tyr Pro Arg Arg Ile Gln 
        115                 120                 125             


Leu Ser Arg Thr Thr Pro Leu Thr Thr Gln Ser Pro Pro Leu Ala Ser 
    130                 135                 140                 


Leu His Asp Thr Asn Phe Leu Asn Asp Ala Asp Met Val Met Ser Phe 
145                 150                 155                 160 


Val Asn Leu Val Glu Arg Asp Lys Asp Phe Ser His Gln Arg Arg His 
                165                 170                 175     


Tyr Lys Glu Phe Arg Phe Asp Leu Thr Gln Ile Pro His Gly Glu Ala 
            180                 185                 190         


Val Thr Ala Ala Glu Phe Arg Ile Tyr Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Phe Glu Asn Glu Thr Ile Lys Ile Ser Ile Tyr Gln Ile Ile Lys Glu 
    210                 215                 220                 


Tyr Thr Asn Arg Asp Ala Asp Leu Phe Leu Leu Asp Thr Arg Lys Ala 
225                 230                 235                 240 


Gln Ala Leu Asp Val Gly Trp Leu Val Phe Asp Ile Thr Val Thr Ser 
                245                 250                 255     


Asn His Trp Val Ile Asn Pro Gln Asn Asn Leu Gly Leu Gln Leu Cys 
            260                 265                 270         


Ala Glu Thr Gly Asp Gly Arg Ser Ile Asn Val Lys Ser Ala Gly Leu 
        275                 280                 285             


Val Gly Arg Gln Gly Pro Gln Ser Lys Gln Pro Phe Met Val Ala Phe 
    290                 295                 300                 


Phe Lys Ala Ser Glu Val Leu Leu Arg Ser Val Arg Ala Ala Asn Lys 
305                 310                 315                 320 


Arg Lys Asn Gln Asn Arg Asn Lys Ser Ser Ser His Gln Asp Ser Ser 
                325                 330                 335     


Arg Met Ser Ser Val Gly Asp Tyr Asn Thr Ser Glu Gln Lys Gln Ala 
            340                 345                 350         


Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln 
        355                 360                 365             


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Phe Tyr Cys Asp Gly 
    370                 375                 380                 


Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala 
385                 390                 395                 400 


Ile Val Gln Thr Leu Val His Leu Met Phe Pro Asp His Val Pro Lys 
                405                 410                 415     


Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe 
            420                 425                 430         


Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
        435                 440                 445             


Arg Ser Cys Gly Cys His 
    450                 


<210>  1190
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP6__Homo_sapiens__NP_001709

<400>  1190

Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
        35                  40                  45              


Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
    50                  55                  60                  


Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln 
65                  70                  75                  80  


Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                85                  90                  95      


His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
        115                 120                 125             


Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
    130                 135                 140                 


Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
145                 150                 155                 160 


Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                165                 170                 175     


Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
            180                 185                 190         


Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe 
        195                 200                 205             


Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
    210                 215                 220                 


Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
225                 230                 235                 240 


Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe 
                245                 250                 255     


Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe 
            260                 265                 270         


Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
        275                 280                 285             


Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly 
    290                 295                 300                 


Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr 
305                 310                 315                 320 


Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly 
                325                 330                 335     


Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
            340                 345                 350         


Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
        355                 360                 365             


His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
    370                 375                 380                 


Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
385                 390                 395                 400 


Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu 
                405                 410                 415     


Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            420                 425                 430         


Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
        435                 440                 445             


Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
    450                 455                 460                 


Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
465                 470                 475                 480 


Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                485                 490                 495     


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
            500                 505                 510         


His 
    


<210>  1191
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP7__Homo_sapiens__NP_001710

<400>  1191

Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
    370                 375                 380                 


Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln 
385                 390                 395                 400 


Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     


Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430     


<210>  1192
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP8B__Homo_sapiens__XP_011540326

<400>  1192

Met Thr Ala Leu Pro Gly Pro Leu Trp Leu Leu Gly Leu Ala Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro 
            20                  25                  30          


Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile 
        35                  40                  45              


Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu 
65                  70                  75                  80  


Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu 
                85                  90                  95      


Arg Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val 
            100                 105                 110         


Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe 
        115                 120                 125             


Arg Phe Asp Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala 
    130                 135                 140                 


Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Thr 
145                 150                 155                 160 


Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu 
                165                 170                 175     


Ser Asp Leu Phe Phe Leu Asp Leu Gln Thr Leu Arg Ala Gly Asp Glu 
            180                 185                 190         


Gly Trp Leu Val Leu Asp Val Thr Ala Ala Ser Asp Cys Trp Leu Leu 
        195                 200                 205             


Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Glu Asp 
    210                 215                 220                 


Gly Glu Thr Trp Thr Gly Trp Gly Trp Thr Lys Asp Ser Arg Leu Gln 
225                 230                 235                 240 


Met Trp Lys Leu Arg Leu Ser Arg Thr Pro Trp Val Leu Ser Leu His 
                245                 250                 255     


Ala Pro Gly Pro Ala Gln Ala Pro Ala Glu Arg Pro Leu Leu Cys Leu 
            260                 265                 270         


Leu Gln Gly His Cys Pro 
        275             


<210>  1193
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMPER__Homo_sapiens__NP_597725

<400>  1193

Met Leu Trp Phe Ser Gly Val Gly Ala Leu Ala Glu Arg Tyr Cys Arg 
1               5                   10                  15      


Arg Ser Pro Gly Ile Thr Cys Cys Val Leu Leu Leu Leu Asn Cys Ser 
            20                  25                  30          


Gly Val Pro Met Ser Leu Ala Ser Ser Phe Leu Thr Gly Ser Val Ala 
        35                  40                  45              


Lys Cys Glu Asn Glu Gly Glu Val Leu Gln Ile Pro Phe Ile Thr Asp 
    50                  55                  60                  


Asn Pro Cys Ile Met Cys Val Cys Leu Asn Lys Glu Val Thr Cys Lys 
65                  70                  75                  80  


Arg Glu Lys Cys Pro Val Leu Ser Arg Asp Cys Ala Leu Ala Ile Lys 
                85                  90                  95      


Gln Arg Gly Ala Cys Cys Glu Gln Cys Lys Gly Cys Thr Tyr Glu Gly 
            100                 105                 110         


Asn Thr Tyr Asn Ser Ser Phe Lys Trp Gln Ser Pro Ala Glu Pro Cys 
        115                 120                 125             


Val Leu Arg Gln Cys Gln Glu Gly Val Val Thr Glu Ser Gly Val Arg 
    130                 135                 140                 


Cys Val Val His Cys Lys Asn Pro Leu Glu His Leu Gly Met Cys Cys 
145                 150                 155                 160 


Pro Thr Cys Pro Gly Cys Val Phe Glu Gly Val Gln Tyr Gln Glu Gly 
                165                 170                 175     


Glu Glu Phe Gln Pro Glu Gly Ser Lys Cys Thr Lys Cys Ser Cys Thr 
            180                 185                 190         


Gly Gly Arg Thr Gln Cys Val Arg Glu Val Cys Pro Ile Leu Ser Cys 
        195                 200                 205             


Pro Gln His Leu Ser His Ile Pro Pro Gly Gln Cys Cys Pro Lys Cys 
    210                 215                 220                 


Leu Gly Gln Arg Lys Val Phe Asp Leu Pro Phe Gly Ser Cys Leu Phe 
225                 230                 235                 240 


Arg Ser Asp Val Tyr Asp Asn Gly Ser Ser Phe Leu Tyr Asp Asn Cys 
                245                 250                 255     


Thr Ala Cys Thr Cys Arg Asp Ser Thr Val Val Cys Lys Arg Lys Cys 
            260                 265                 270         


Ser His Pro Gly Gly Cys Asp Gln Gly Gln Glu Gly Cys Cys Glu Glu 
        275                 280                 285             


Cys Leu Leu Arg Val Pro Pro Glu Asp Ile Lys Val Cys Lys Phe Gly 
    290                 295                 300                 


Asn Lys Ile Phe Gln Asp Gly Glu Met Trp Ser Ser Ile Asn Cys Thr 
305                 310                 315                 320 


Ile Cys Ala Cys Val Lys Gly Arg Thr Glu Cys Arg Asn Lys Gln Cys 
                325                 330                 335     


Ile Pro Ile Ser Ser Cys Pro Gln Gly Lys Ile Leu Asn Arg Lys Gly 
            340                 345                 350         


Cys Cys Pro Ile Cys Thr Glu Lys Pro Gly Val Cys Thr Val Phe Gly 
        355                 360                 365             


Asp Pro His Tyr Asn Thr Phe Asp Gly Arg Thr Phe Asn Phe Gln Gly 
    370                 375                 380                 


Thr Cys Gln Tyr Val Leu Thr Lys Asp Cys Ser Ser Pro Ala Ser Pro 
385                 390                 395                 400 


Phe Gln Val Leu Val Lys Asn Asp Ala Arg Arg Thr Arg Ser Phe Ser 
                405                 410                 415     


Trp Thr Lys Ser Val Glu Leu Val Leu Gly Glu Ser Arg Val Ser Leu 
            420                 425                 430         


Gln Gln His Leu Thr Val Arg Trp Asn Gly Ser Arg Ile Ala Leu Pro 
        435                 440                 445             


Cys Arg Ala Pro His Phe His Ile Asp Leu Asp Gly Tyr Leu Leu Lys 
    450                 455                 460                 


Val Thr Thr Lys Ala Gly Leu Glu Ile Ser Trp Asp Gly Asp Ser Phe 
465                 470                 475                 480 


Val Glu Val Met Ala Ala Pro His Leu Lys Gly Lys Leu Cys Gly Leu 
                485                 490                 495     


Cys Gly Asn Tyr Asn Gly His Lys Arg Asp Asp Leu Ile Gly Gly Asp 
            500                 505                 510         


Gly Asn Phe Lys Phe Asp Val Asp Asp Phe Ala Glu Ser Trp Arg Val 
        515                 520                 525             


Glu Ser Asn Glu Phe Cys Asn Arg Pro Gln Arg Lys Pro Val Pro Glu 
    530                 535                 540                 


Leu Cys Gln Gly Thr Val Lys Val Lys Leu Arg Ala His Arg Glu Cys 
545                 550                 555                 560 


Gln Lys Leu Lys Ser Trp Glu Phe Gln Thr Cys His Ser Thr Val Asp 
                565                 570                 575     


Tyr Ala Thr Phe Tyr Arg Ser Cys Val Thr Asp Met Cys Glu Cys Pro 
            580                 585                 590         


Val His Lys Asn Cys Tyr Cys Glu Ser Phe Leu Ala Tyr Thr Arg Ala 
        595                 600                 605             


Cys Gln Arg Glu Gly Ile Lys Val His Trp Glu Pro Gln Gln Asn Cys 
    610                 615                 620                 


Ala Ala Thr Gln Cys Lys His Gly Ala Val Tyr Asp Thr Cys Gly Pro 
625                 630                 635                 640 


Gly Cys Ile Lys Thr Cys Asp Asn Trp Asn Glu Ile Gly Pro Cys Asn 
                645                 650                 655     


Lys Pro Cys Val Ala Gly Cys His Cys Pro Ala Asn Leu Val Leu His 
            660                 665                 670         


Lys Gly Arg Cys Ile Lys Pro Val Leu Cys Pro Gln Arg 
        675                 680                 685 


<210>  1194
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMPR1A__Homo_sapiens__NP_004320

<400>  1194

Met Pro Gln Leu Tyr Ile Tyr Ile Arg Leu Leu Gly Ala Tyr Leu Phe 
1               5                   10                  15      


Ile Ile Ser Arg Val Gln Gly Gln Asn Leu Asp Ser Met Leu His Gly 
            20                  25                  30          


Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val 
        35                  40                  45              


Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser 
    50                  55                  60                  


Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly 
65                  70                  75                  80  


His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu 
                85                  90                  95      


Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp 
            100                 105                 110         


Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn 
        115                 120                 125             


Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly 
    130                 135                 140                 


Pro Phe Phe Asp Gly Ser Ile Arg Trp Leu Val Leu Leu Ile Ser Met 
145                 150                 155                 160 


Ala Val Cys Ile Ile Ala Met Ile Ile Phe Ser Ser Cys Phe Cys Tyr 
                165                 170                 175     


Lys His Tyr Cys Lys Ser Ile Ser Ser Arg Arg Arg Tyr Asn Arg Asp 
            180                 185                 190         


Leu Glu Gln Asp Glu Ala Phe Ile Pro Val Gly Glu Ser Leu Lys Asp 
        195                 200                 205             


Leu Ile Asp Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu 
    210                 215                 220                 


Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
225                 230                 235                 240 


Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
                245                 250                 255     


Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
            260                 265                 270         


Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
        275                 280                 285             


Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
    290                 295                 300                 


Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
305                 310                 315                 320 


Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
                325                 330                 335     


Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
            340                 345                 350         


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
        355                 360                 365             


Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
    370                 375                 380                 


Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr 
385                 390                 395                 400 


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
                405                 410                 415     


Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
            420                 425                 430         


Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
        435                 440                 445             


Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
    450                 455                 460                 


Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
465                 470                 475                 480 


Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
                485                 490                 495     


Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
            500                 505                 510         


Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
        515                 520                 525             


Asp Val Lys Ile 
    530         


<210>  1195
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMPR1B__Homo_sapiens__NP_001243721

<400>  1195

Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Thr Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ala Pro Thr Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Thr Asp Gly Tyr Cys Phe Thr Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Thr Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Asp Thr Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys 
                85                  90                  95      


Thr Glu Arg Asn Glu Cys Asn Lys Asp Leu His Pro Thr Leu Pro Pro 
            100                 105                 110         


Leu Lys Asn Arg Asp Phe Val Asp Gly Pro Ile His His Arg Ala Leu 
        115                 120                 125             


Leu Ile Ser Val Thr Val Cys Ser Leu Leu Leu Val Leu Ile Ile Leu 
    130                 135                 140                 


Phe Cys Tyr Phe Arg Tyr Lys Arg Gln Glu Thr Arg Pro Arg Tyr Ser 
145                 150                 155                 160 


Ile Gly Leu Glu Gln Asp Glu Thr Tyr Ile Pro Pro Gly Glu Ser Leu 
                165                 170                 175     


Arg Asp Leu Ile Glu Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu 
            180                 185                 190         


Pro Leu Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Lys 
        195                 200                 205             


Gln Ile Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg 
    210                 215                 220                 


Gly Glu Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser 
225                 230                 235                 240 


Trp Phe Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu 
                245                 250                 255     


Asn Ile Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp 
            260                 265                 270         


Thr Gln Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr 
        275                 280                 285             


Asp Tyr Leu Lys Ser Thr Thr Leu Asp Ala Lys Ser Met Leu Lys Leu 
    290                 295                 300                 


Ala Tyr Ser Ser Val Ser Gly Leu Cys His Leu His Thr Glu Ile Phe 
305                 310                 315                 320 


Ser Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys 
                325                 330                 335     


Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly 
            340                 345                 350         


Leu Ala Val Lys Phe Ile Ser Asp Thr Asn Glu Val Asp Ile Pro Pro 
        355                 360                 365             


Asn Thr Arg Val Gly Thr Lys Arg Tyr Met Pro Pro Glu Val Leu Asp 
    370                 375                 380                 


Glu Ser Leu Asn Arg Asn His Phe Gln Ser Tyr Ile Met Ala Asp Met 
385                 390                 395                 400 


Tyr Ser Phe Gly Leu Ile Leu Trp Glu Val Ala Arg Arg Cys Val Ser 
                405                 410                 415     


Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr His Asp Leu Val Pro 
            420                 425                 430         


Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Ile Val Cys Ile Lys Lys 
        435                 440                 445             


Leu Arg Pro Ser Phe Pro Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg 
    450                 455                 460                 


Gln Met Gly Lys Leu Met Thr Glu Cys Trp Ala His Asn Pro Ala Ser 
465                 470                 475                 480 


Arg Leu Thr Ala Leu Arg Val Lys Lys Thr Leu Ala Lys Met Ser Glu 
                485                 490                 495     


Ser Gln Asp Ile Lys Leu 
            500         


<210>  1196
<211>  1038
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMPR2__Homo_sapiens__NP_001195

<400>  1196

Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro 
    530                 535                 540                 


Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp 
545                 550                 555                 560 


Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro 
                565                 570                 575     


Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln 
            580                 585                 590         


Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu 
        595                 600                 605             


Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr 
    610                 615                 620                 


Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu 
625                 630                 635                 640 


His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu 
                645                 650                 655     


Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu 
            660                 665                 670         


Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His 
        675                 680                 685             


Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser 
    690                 695                 700                 


Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln 
705                 710                 715                 720 


Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp 
                725                 730                 735     


Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro 
            740                 745                 750         


Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu 
        755                 760                 765             


Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val 
    770                 775                 780                 


Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His 
785                 790                 795                 800 


Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val 
                805                 810                 815     


Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser 
            820                 825                 830         


Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln 
        835                 840                 845             


Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro 
    850                 855                 860                 


Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp 
865                 870                 875                 880 


Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu 
                885                 890                 895     


Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu 
            900                 905                 910         


Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly 
        915                 920                 925             


Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser 
    930                 935                 940                 


Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr 
945                 950                 955                 960 


Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys 
                965                 970                 975     


Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser 
            980                 985                 990         


Thr Glu Ser Leu Asp Cys Glu Val  Asn Asn Asn Gly Ser  Asn Arg Ala 
        995                 1000                 1005             


Val His  Ser Lys Ser Ser Thr  Ala Val Tyr Leu Ala  Glu Gly Gly 
    1010                 1015                 1020             


Thr Ala  Thr Thr Met Val Ser  Lys Asp Ile Gly Met  Asn Cys Leu 
    1025                 1030                 1035             


<210>  1197
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMS1__Homo_sapiens__NP_055568

<400>  1197

Met Glu Ala Lys Asp Gln Lys Lys His Arg Lys Lys Asn Ser Gly Pro 
1               5                   10                  15      


Lys Ala Ala Lys Lys Lys Lys Arg Leu Leu Gln Asp Leu Gln Leu Gly 
            20                  25                  30          


Asp Glu Glu Asp Ala Arg Lys Arg Asn Pro Lys Ala Phe Ala Val Gln 
        35                  40                  45              


Ser Ala Val Arg Met Ala Arg Ser Phe His Arg Thr Gln Asp Leu Lys 
    50                  55                  60                  


Thr Lys Lys His His Ile Pro Val Val Asp Arg Thr Pro Leu Glu Pro 
65                  70                  75                  80  


Pro Pro Ile Val Val Val Val Met Gly Pro Pro Lys Val Gly Lys Ser 
                85                  90                  95      


Thr Leu Ile Gln Cys Leu Ile Arg Asn Phe Thr Arg Gln Lys Leu Thr 
            100                 105                 110         


Glu Ile Arg Gly Pro Val Thr Ile Val Ser Gly Lys Lys Arg Arg Leu 
        115                 120                 125             


Thr Ile Ile Glu Cys Gly Cys Asp Ile Asn Met Met Ile Asp Leu Ala 
    130                 135                 140                 


Lys Val Ala Asp Leu Val Leu Met Leu Ile Asp Ala Ser Phe Gly Phe 
145                 150                 155                 160 


Glu Met Glu Thr Phe Glu Phe Leu Asn Ile Cys Gln Val His Gly Phe 
                165                 170                 175     


Pro Lys Ile Met Gly Val Leu Thr His Leu Asp Ser Phe Lys His Asn 
            180                 185                 190         


Lys Gln Leu Lys Lys Thr Lys Lys Arg Leu Lys His Arg Phe Trp Thr 
        195                 200                 205             


Glu Val Tyr Pro Gly Ala Lys Leu Phe Tyr Leu Ser Gly Met Val His 
    210                 215                 220                 


Gly Glu Tyr Gln Asn Gln Glu Ile His Asn Leu Gly Arg Phe Ile Thr 
225                 230                 235                 240 


Val Met Lys Phe Arg Pro Leu Thr Trp Gln Thr Ser His Pro Tyr Ile 
                245                 250                 255     


Leu Ala Asp Arg Met Glu Asp Leu Thr Asn Pro Glu Asp Ile Arg Thr 
            260                 265                 270         


Asn Ile Lys Cys Asp Arg Lys Val Ser Leu Tyr Gly Tyr Leu Arg Gly 
        275                 280                 285             


Ala His Leu Lys Asn Lys Ser Gln Ile His Met Pro Gly Val Gly Asp 
    290                 295                 300                 


Phe Ala Val Ser Asp Ile Ser Phe Leu Pro Asp Pro Cys Ala Leu Pro 
305                 310                 315                 320 


Glu Gln Gln Lys Lys Arg Cys Leu Asn Glu Lys Glu Lys Leu Val Tyr 
                325                 330                 335     


Ala Pro Leu Ser Gly Val Gly Gly Val Leu Tyr Asp Lys Asp Ala Val 
            340                 345                 350         


Tyr Val Asp Leu Gly Gly Ser His Val Phe Gln Asp Glu Val Gly Pro 
        355                 360                 365             


Thr His Glu Leu Val Gln Ser Leu Ile Ser Thr His Ser Thr Ile Asp 
    370                 375                 380                 


Ala Lys Met Ala Ser Ser Arg Val Thr Leu Phe Ser Asp Ser Lys Pro 
385                 390                 395                 400 


Leu Gly Ser Glu Asp Ile Asp Asn Gln Gly Leu Met Met Pro Lys Glu 
                405                 410                 415     


Glu Lys Gln Met Asp Leu Asn Thr Gly Arg Met Arg Arg Lys Ala Ile 
            420                 425                 430         


Phe Gly Asp Glu Asp Glu Ser Gly Asp Ser Asp Asp Glu Glu Asp Asp 
        435                 440                 445             


Glu Met Ser Glu Asp Asp Gly Leu Glu Asn Gly Ser Ser Asp Glu Glu 
    450                 455                 460                 


Ala Glu Glu Glu Glu Asn Ala Glu Met Thr Asp Gln Tyr Met Ala Val 
465                 470                 475                 480 


Lys Gly Ile Lys Arg Arg Lys Leu Glu Leu Glu Glu Asp Ser Glu Met 
                485                 490                 495     


Asp Leu Pro Ala Phe Ala Asp Ser Asp Asp Asp Leu Glu Arg Ser Ser 
            500                 505                 510         


Ala Glu Glu Gly Glu Ala Glu Glu Ala Asp Glu Ser Ser Glu Glu Glu 
        515                 520                 525             


Asp Cys Thr Ala Gly Glu Lys Gly Ile Ser Gly Ser Lys Ala Ala Gly 
    530                 535                 540                 


Glu Gly Ser Lys Ala Gly Leu Ser Pro Ala Asn Cys Gln Ser Asp Arg 
545                 550                 555                 560 


Val Asn Leu Glu Lys Ser Leu Leu Met Lys Lys Ala Ala Leu Pro Thr 
                565                 570                 575     


Phe Asp Ser Gly His Cys Thr Ala Glu Glu Val Phe Ala Ser Glu Asp 
            580                 585                 590         


Glu Ser Glu Glu Ser Ser Ser Leu Ser Ala Glu Glu Glu Asp Ser Glu 
        595                 600                 605             


Asn Glu Glu Ala Ile Arg Lys Lys Leu Ser Lys Pro Ser Gln Val Ser 
    610                 615                 620                 


Ser Gly Gln Lys Leu Gly Pro Gln Asn Phe Ile Asp Glu Thr Ser Asp 
625                 630                 635                 640 


Ile Glu Asn Leu Leu Lys Glu Glu Glu Asp Tyr Lys Glu Glu Asn Asn 
                645                 650                 655     


Asp Ser Lys Glu Thr Ser Gly Ala Leu Lys Trp Lys Glu Asp Leu Ser 
            660                 665                 670         


Arg Lys Ala Ala Glu Ala Phe Leu Arg Gln Gln Gln Ala Ala Pro Asn 
        675                 680                 685             


Leu Arg Lys Leu Ile Tyr Gly Thr Val Thr Glu Asp Asn Glu Glu Glu 
    690                 695                 700                 


Asp Asp Asp Thr Leu Glu Glu Leu Gly Gly Leu Phe Arg Val Asn Gln 
705                 710                 715                 720 


Pro Asp Arg Glu Cys Lys His Lys Ala Asp Ser Leu Asp Cys Ser Arg 
                725                 730                 735     


Phe Leu Val Glu Ala Pro His Asp Trp Asp Leu Glu Glu Val Met Asn 
            740                 745                 750         


Ser Ile Arg Asp Cys Phe Val Thr Gly Lys Trp Glu Asp Asp Lys Asp 
        755                 760                 765             


Ala Ala Lys Val Leu Ala Glu Asp Glu Glu Leu Tyr Gly Asp Phe Glu 
    770                 775                 780                 


Asp Leu Glu Thr Gly Asp Val His Lys Gly Lys Ser Gly Pro Asn Thr 
785                 790                 795                 800 


Gln Asn Glu Asp Ile Glu Lys Glu Val Lys Glu Glu Ile Asp Pro Asp 
                805                 810                 815     


Glu Glu Glu Ser Ala Lys Lys Lys His Leu Asp Lys Lys Arg Lys Leu 
            820                 825                 830         


Lys Glu Met Phe Asp Ala Glu Tyr Asp Glu Gly Glu Ser Thr Tyr Phe 
        835                 840                 845             


Asp Asp Leu Lys Gly Glu Met Gln Lys Gln Ala Gln Leu Asn Arg Ala 
    850                 855                 860                 


Glu Phe Glu Asp Gln Asp Asp Glu Ala Arg Val Gln Tyr Glu Gly Phe 
865                 870                 875                 880 


Arg Pro Gly Met Tyr Val Arg Ile Glu Ile Glu Asn Val Pro Cys Glu 
                885                 890                 895     


Phe Val Gln Asn Phe Asp Pro His Tyr Pro Ile Ile Leu Gly Gly Leu 
            900                 905                 910         


Gly Asn Ser Glu Gly Asn Val Gly Tyr Val Gln Met Arg Leu Lys Lys 
        915                 920                 925             


His Arg Trp Tyr Lys Lys Ile Leu Lys Ser Arg Asp Pro Ile Ile Phe 
    930                 935                 940                 


Ser Val Gly Trp Arg Arg Phe Gln Thr Ile Pro Leu Tyr Tyr Ile Glu 
945                 950                 955                 960 


Asp His Asn Gly Arg Gln Arg Leu Leu Lys Tyr Thr Pro Gln His Met 
                965                 970                 975     


His Cys Gly Ala Ala Phe Trp Gly Pro Ile Thr Pro Gln Gly Thr Gly 
            980                 985                 990         


Phe Leu Ala Ile Gln Ser Val Ser  Gly Ile Met Pro Asp  Phe Arg Ile 
        995                 1000                 1005             


Ala Ala  Thr Gly Val Val Leu  Asp Leu Asp Lys Ser  Ile Lys Ile 
    1010                 1015                 1020             


Val Lys  Lys Leu Lys Leu Thr  Gly Phe Pro Tyr Lys  Ile Phe Lys 
    1025                 1030                 1035             


Asn Thr  Ser Phe Ile Lys Gly  Met Phe Asn Ser Ala  Leu Glu Val 
    1040                 1045                 1050             


Ala Lys  Phe Glu Gly Ala Val  Ile Arg Thr Val Ser  Gly Ile Arg 
    1055                 1060                 1065             


Gly Gln  Ile Lys Lys Ala Leu  Arg Ala Pro Glu Gly  Ala Phe Arg 
    1070                 1075                 1080             


Ala Ser  Phe Glu Asp Lys Leu  Leu Met Ser Asp Ile  Val Phe Met 
    1085                 1090                 1095             


Arg Thr  Trp Tyr Pro Val Ser  Ile Pro Ala Phe Tyr  Asn Pro Val 
    1100                 1105                 1110             


Thr Ser  Leu Leu Lys Pro Val  Gly Glu Lys Asp Thr  Trp Ser Gly 
    1115                 1120                 1125             


Met Arg  Thr Thr Gly Gln Leu  Arg Leu Ala His Gly  Val Arg Leu 
    1130                 1135                 1140             


Lys Ala  Asn Lys Asp Ser Leu  Tyr Lys Pro Ile Leu  Arg Gln Lys 
    1145                 1150                 1155             


Lys His  Phe Asn Ser Leu His  Ile Pro Lys Ala Leu  Gln Lys Ala 
    1160                 1165                 1170             


Leu Pro  Phe Lys Asn Lys Pro  Lys Thr Gln Ala Lys  Ala Gly Lys 
    1175                 1180                 1185             


Val Pro  Lys Asp Arg Arg Arg  Pro Ala Val Ile Arg  Glu Pro His 
    1190                 1195                 1200             


Glu Arg  Lys Ile Leu Ala Leu  Leu Asp Ala Leu Ser  Thr Val His 
    1205                 1210                 1215             


Ser Gln  Lys Met Lys Lys Ala  Lys Glu Gln Arg His  Leu His Asn 
    1220                 1225                 1230             


Lys Glu  His Phe Arg Ala Lys  Gln Lys Glu Glu Glu  Glu Lys Leu 
    1235                 1240                 1245             


Lys Arg  Gln Lys Asp Leu Arg  Lys Lys Leu Phe Arg  Ile Gln Gly 
    1250                 1255                 1260             


Gln Lys  Glu Arg Arg Asn Gln  Lys Ser Ser Leu Lys  Gly Ala Glu 
    1265                 1270                 1275             


Gly Gln  Leu Gln 
    1280         


<210>  1198
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMX__Homo_sapiens__NP_001712

<400>  1198

Met Asp Thr Lys Ser Ile Leu Glu Glu Leu Leu Leu Lys Arg Ser Gln 
1               5                   10                  15      


Gln Lys Lys Lys Met Ser Pro Asn Asn Tyr Lys Glu Arg Leu Phe Val 
            20                  25                  30          


Leu Thr Lys Thr Asn Leu Ser Tyr Tyr Glu Tyr Asp Lys Met Lys Arg 
        35                  40                  45              


Gly Ser Arg Lys Gly Ser Ile Glu Ile Lys Lys Ile Arg Cys Val Glu 
    50                  55                  60                  


Lys Val Asn Leu Glu Glu Gln Thr Pro Val Glu Arg Gln Tyr Pro Phe 
65                  70                  75                  80  


Gln Ile Val Tyr Lys Asp Gly Leu Leu Tyr Val Tyr Ala Ser Asn Glu 
                85                  90                  95      


Glu Ser Arg Ser Gln Trp Leu Lys Ala Leu Gln Lys Glu Ile Arg Gly 
            100                 105                 110         


Asn Pro His Leu Leu Val Lys Tyr His Ser Gly Phe Phe Val Asp Gly 
        115                 120                 125             


Lys Phe Leu Cys Cys Gln Gln Ser Cys Lys Ala Ala Pro Gly Cys Thr 
    130                 135                 140                 


Leu Trp Glu Ala Tyr Ala Asn Leu His Thr Ala Val Asn Glu Glu Lys 
145                 150                 155                 160 


His Arg Val Pro Thr Phe Pro Asp Arg Val Leu Lys Ile Pro Arg Ala 
                165                 170                 175     


Val Pro Val Leu Lys Met Asp Ala Pro Ser Ser Ser Thr Thr Leu Ala 
            180                 185                 190         


Gln Tyr Asp Asn Glu Ser Lys Lys Asn Tyr Gly Ser Gln Pro Pro Ser 
        195                 200                 205             


Ser Ser Thr Ser Leu Ala Gln Tyr Asp Ser Asn Ser Lys Lys Ile Tyr 
    210                 215                 220                 


Gly Ser Gln Pro Asn Phe Asn Met Gln Tyr Ile Pro Arg Glu Asp Phe 
225                 230                 235                 240 


Pro Asp Trp Trp Gln Val Arg Lys Leu Lys Ser Ser Ser Ser Ser Glu 
                245                 250                 255     


Asp Val Ala Ser Ser Asn Gln Lys Glu Arg Asn Val Asn His Thr Thr 
            260                 265                 270         


Ser Lys Ile Ser Trp Glu Phe Pro Glu Ser Ser Ser Ser Glu Glu Glu 
        275                 280                 285             


Glu Asn Leu Asp Asp Tyr Asp Trp Phe Ala Gly Asn Ile Ser Arg Ser 
    290                 295                 300                 


Gln Ser Glu Gln Leu Leu Arg Gln Lys Gly Lys Glu Gly Ala Phe Met 
305                 310                 315                 320 


Val Arg Asn Ser Ser Gln Val Gly Met Tyr Thr Val Ser Leu Phe Ser 
                325                 330                 335     


Lys Ala Val Asn Asp Lys Lys Gly Thr Val Lys His Tyr His Val His 
            340                 345                 350         


Thr Asn Ala Glu Asn Lys Leu Tyr Leu Ala Glu Asn Tyr Cys Phe Asp 
        355                 360                 365             


Ser Ile Pro Lys Leu Ile His Tyr His Gln His Asn Ser Ala Gly Met 
    370                 375                 380                 


Ile Thr Arg Leu Arg His Pro Val Ser Thr Lys Ala Asn Lys Val Pro 
385                 390                 395                 400 


Asp Ser Val Ser Leu Gly Asn Gly Ile Trp Glu Leu Lys Arg Glu Glu 
                405                 410                 415     


Ile Thr Leu Leu Lys Glu Leu Gly Ser Gly Gln Phe Gly Val Val Gln 
            420                 425                 430         


Leu Gly Lys Trp Lys Gly Gln Tyr Asp Val Ala Val Lys Met Ile Lys 
        435                 440                 445             


Glu Gly Ser Met Ser Glu Asp Glu Phe Phe Gln Glu Ala Gln Thr Met 
    450                 455                 460                 


Met Lys Leu Ser His Pro Lys Leu Val Lys Phe Tyr Gly Val Cys Ser 
465                 470                 475                 480 


Lys Glu Tyr Pro Ile Tyr Ile Val Thr Glu Tyr Ile Ser Asn Gly Cys 
                485                 490                 495     


Leu Leu Asn Tyr Leu Arg Ser His Gly Lys Gly Leu Glu Pro Ser Gln 
            500                 505                 510         


Leu Leu Glu Met Cys Tyr Asp Val Cys Glu Gly Met Ala Phe Leu Glu 
        515                 520                 525             


Ser His Gln Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val 
    530                 535                 540                 


Asp Arg Asp Leu Cys Val Lys Val Ser Asp Phe Gly Met Thr Arg Tyr 
545                 550                 555                 560 


Val Leu Asp Asp Gln Tyr Val Ser Ser Val Gly Thr Lys Phe Pro Val 
                565                 570                 575     


Lys Trp Ser Ala Pro Glu Val Phe His Tyr Phe Lys Tyr Ser Ser Lys 
            580                 585                 590         


Ser Asp Val Trp Ala Phe Gly Ile Leu Met Trp Glu Val Phe Ser Leu 
        595                 600                 605             


Gly Lys Gln Pro Tyr Asp Leu Tyr Asp Asn Ser Gln Val Val Leu Lys 
    610                 615                 620                 


Val Ser Gln Gly His Arg Leu Tyr Arg Pro His Leu Ala Ser Asp Thr 
625                 630                 635                 640 


Ile Tyr Gln Ile Met Tyr Ser Cys Trp His Glu Leu Pro Glu Lys Arg 
                645                 650                 655     


Pro Thr Phe Gln Gln Leu Leu Ser Ser Ile Glu Pro Leu Arg Glu Lys 
            660                 665                 670         


Asp Lys His 
        675 


<210>  1199
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNC1__Homo_sapiens__NP_001288135

<400>  1199

Met Arg Cys Arg Asn Met Phe Phe Ser Phe Lys Ala Ser Leu Cys Gly 
1               5                   10                  15      


Cys Gly Ala Ala Thr Ala Pro Ser Leu Thr Ala Ile Ser Cys Thr Leu 
            20                  25                  30          


Asn Cys Ser Cys Gln Ser Phe Lys Pro Gly Lys Ile Asn His Arg Gln 
        35                  40                  45              


Cys Asp Gln Cys Lys His Gly Trp Val Ala His Ala Leu Ser Lys Leu 
    50                  55                  60                  


Arg Ile Pro Pro Met Tyr Pro Thr Ser Gln Val Glu Ile Val Gln Ser 
65                  70                  75                  80  


Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu Tyr Gly Thr Gln Ala 
                85                  90                  95      


Ile Pro Val Arg Leu Lys Ile Leu Leu Asp Arg Leu Phe Ser Val Leu 
            100                 105                 110         


Lys Gln Asp Glu Val Leu Gln Ile Leu His Ala Leu Asp Trp Thr Leu 
        115                 120                 125             


Gln Asp Tyr Ile Arg Gly Tyr Val Leu Gln Asp Ala Ser Gly Lys Val 
    130                 135                 140                 


Leu Asp His Trp Ser Ile Met Thr Ser Glu Glu Glu Val Ala Thr Leu 
145                 150                 155                 160 


Gln Gln Phe Leu Arg Phe Gly Glu Thr Lys Ser Ile Val Glu Leu Met 
                165                 170                 175     


Ala Ile Gln Glu Lys Glu Glu Gln Ser Ile Ile Ile Pro Pro Ser Thr 
            180                 185                 190         


Ala Asn Val Asp Ile Arg Ala Phe Ile Glu Ser Cys Ser His Arg Ser 
        195                 200                 205             


Ser Ser Leu Pro Thr Pro Val Asp Lys Gly Asn Pro Ser Ser Ile His 
    210                 215                 220                 


Pro Phe Glu Asn Leu Ile Ser Asn Met Thr Phe Met Leu Pro Phe Gln 
225                 230                 235                 240 


Phe Phe Asn Pro Leu Pro Pro Ala Leu Ile Gly Ser Leu Pro Glu Gln 
                245                 250                 255     


Tyr Met Leu Glu Gln Gly His Asp Gln Ser Gln Asp Pro Lys Gln Glu 
            260                 265                 270         


Val His Gly Pro Phe Pro Asp Ser Ser Phe Leu Thr Ser Ser Ser Thr 
        275                 280                 285             


Pro Phe Gln Val Glu Lys Asp Gln Cys Leu Asn Cys Pro Asp Ala Ile 
    290                 295                 300                 


Thr Lys Lys Glu Asp Ser Thr His Leu Ser Asp Ser Ser Ser Tyr Asn 
305                 310                 315                 320 


Ile Val Thr Lys Phe Glu Arg Thr Gln Leu Ser Pro Glu Ala Lys Val 
                325                 330                 335     


Lys Pro Glu Arg Asn Ser Leu Gly Thr Lys Lys Gly Arg Val Phe Cys 
            340                 345                 350         


Thr Ala Cys Glu Lys Thr Phe Tyr Asp Lys Gly Thr Leu Lys Ile His 
        355                 360                 365             


Tyr Asn Ala Val His Leu Lys Ile Lys His Lys Cys Thr Ile Glu Gly 
    370                 375                 380                 


Cys Asn Met Val Phe Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala 
385                 390                 395                 400 


Asn Pro Asn Pro Arg Leu His Met Pro Met Asn Arg Asn Asn Arg Asp 
                405                 410                 415     


Lys Asp Leu Arg Asn Ser Leu Asn Leu Ala Ser Ser Glu Asn Tyr Lys 
            420                 425                 430         


Cys Pro Gly Phe Thr Val Thr Ser Pro Asp Cys Arg Pro Pro Pro Ser 
        435                 440                 445             


Tyr Pro Gly Ser Gly Glu Asp Ser Lys Gly Gln Pro Ala Phe Pro Asn 
    450                 455                 460                 


Ile Gly Gln Asn Gly Val Leu Phe Pro Asn Leu Lys Thr Val Gln Pro 
465                 470                 475                 480 


Val Leu Pro Phe Tyr Arg Ser Pro Ala Thr Pro Ala Glu Val Ala Asn 
                485                 490                 495     


Thr Pro Gly Ile Leu Pro Ser Leu Pro Leu Leu Ser Ser Ser Ile Pro 
            500                 505                 510         


Glu Gln Leu Ile Ser Asn Glu Met Pro Phe Asp Ala Leu Pro Lys Lys 
        515                 520                 525             


Lys Ser Arg Lys Ser Ser Met Pro Ile Lys Ile Glu Lys Glu Ala Val 
    530                 535                 540                 


Glu Ile Ala Asn Glu Lys Arg His Asn Leu Ser Ser Asp Glu Asp Met 
545                 550                 555                 560 


Pro Leu Gln Val Val Ser Glu Asp Glu Gln Glu Ala Cys Ser Pro Gln 
                565                 570                 575     


Ser His Arg Val Ser Glu Glu Gln His Val Gln Ser Gly Gly Leu Gly 
            580                 585                 590         


Lys Pro Phe Pro Glu Gly Glu Arg Pro Cys His Arg Glu Ser Val Ile 
        595                 600                 605             


Glu Ser Ser Gly Ala Ile Ser Gln Thr Pro Glu Gln Ala Thr His Asn 
    610                 615                 620                 


Ser Glu Arg Glu Thr Glu Gln Thr Pro Ala Leu Ile Met Val Pro Arg 
625                 630                 635                 640 


Glu Val Glu Asp Gly Gly His Glu His Tyr Phe Thr Pro Gly Met Glu 
                645                 650                 655     


Pro Gln Val Pro Phe Ser Asp Tyr Met Glu Leu Gln Gln Arg Leu Leu 
            660                 665                 670         


Ala Gly Gly Leu Phe Ser Ala Leu Ser Asn Arg Gly Met Ala Phe Pro 
        675                 680                 685             


Cys Leu Glu Asp Ser Lys Glu Leu Glu His Val Gly Gln His Ala Leu 
    690                 695                 700                 


Ala Arg Gln Ile Glu Glu Asn Arg Phe Gln Cys Asp Ile Cys Lys Lys 
705                 710                 715                 720 


Thr Phe Lys Asn Ala Cys Ser Val Lys Ile His His Lys Asn Met His 
                725                 730                 735     


Val Lys Glu Met His Thr Cys Thr Val Glu Gly Cys Asn Ala Thr Phe 
            740                 745                 750         


Pro Ser Arg Arg Ser Arg Asp Arg His Ser Ser Asn Leu Asn Leu His 
        755                 760                 765             


Gln Lys Ala Leu Ser Gln Glu Ala Leu Glu Ser Ser Glu Asp His Phe 
    770                 775                 780                 


Arg Ala Ala Tyr Leu Leu Lys Asp Val Ala Lys Glu Ala Tyr Gln Asp 
785                 790                 795                 800 


Val Ala Phe Thr Gln Gln Ala Ser Gln Thr Ser Val Ile Phe Lys Gly 
                805                 810                 815     


Thr Ser Arg Met Gly Ser Leu Val Tyr Pro Ile Thr Gln Val His Ser 
            820                 825                 830         


Ala Ser Leu Glu Ser Tyr Asn Ser Gly Pro Leu Ser Glu Gly Thr Ile 
        835                 840                 845             


Leu Asp Leu Ser Thr Thr Ser Ser Met Lys Ser Glu Ser Ser Ser His 
    850                 855                 860                 


Ser Ser Trp Asp Ser Asp Gly Val Ser Glu Glu Gly Thr Val Leu Met 
865                 870                 875                 880 


Glu Asp Ser Asp Gly Asn Cys Glu Gly Ser Ser Leu Val Pro Gly Glu 
                885                 890                 895     


Asp Glu Tyr Pro Ile Cys Val Leu Met Glu Lys Ala Asp Gln Ser Leu 
            900                 905                 910         


Ala Ser Leu Pro Ser Gly Leu Pro Ile Thr Cys His Leu Cys Gln Lys 
        915                 920                 925             


Thr Tyr Ser Asn Lys Gly Thr Phe Arg Ala His Tyr Lys Thr Val His 
    930                 935                 940                 


Leu Arg Gln Leu His Lys Cys Lys Val Pro Gly Cys Asn Thr Met Phe 
945                 950                 955                 960 


Ser Ser Val Arg Ser Arg Asn Arg His Ser Gln Asn Pro Asn Leu His 
                965                 970                 975     


Lys Ser Leu Ala Ser Ser Pro Ser His Leu Gln 
            980                 985         


<210>  1200
<211>  1099
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNC2__Homo_sapiens__NP_060107

<400>  1200

Met Ala His Leu Gly Pro Thr Pro Pro Pro His Ser Leu Asn Tyr Lys 
1               5                   10                  15      


Ser Glu Asp Arg Leu Ser Glu Gln Asp Trp Pro Ala Tyr Phe Lys Val 
            20                  25                  30          


Pro Cys Cys Gly Val Asp Thr Ser Gln Ile Glu Ser Glu Glu Ala Glu 
        35                  40                  45              


Val Asp Val Arg Glu Arg Glu Thr Gln Arg Asp Arg Glu Pro Lys Arg 
    50                  55                  60                  


Ala Arg Asp Leu Thr Leu Arg Asp Ser Cys Thr Asp Asn Ser Met Gln 
65                  70                  75                  80  


Phe Gly Thr Arg Thr Thr Thr Ala Glu Pro Gly Phe Met Gly Thr Trp 
                85                  90                  95      


Gln Asn Ala Asp Thr Asn Leu Leu Phe Arg Met Ser Gln Gln Ala Ile 
            100                 105                 110         


Arg Cys Thr Leu Val Asn Cys Thr Cys Glu Cys Phe Gln Pro Gly Lys 
        115                 120                 125             


Ile Asn Leu Arg Thr Cys Asp Gln Cys Lys His Gly Trp Val Ala His 
    130                 135                 140                 


Ala Leu Asp Lys Leu Ser Thr Gln His Leu Tyr His Pro Thr Gln Val 
145                 150                 155                 160 


Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu 
                165                 170                 175     


Tyr Gly Thr Gln Ala Val Pro Val Arg Leu Lys Ile Leu Leu Asp Arg 
            180                 185                 190         


Leu Phe Ser Val Leu Lys Gln Glu Glu Val Leu His Ile Leu His Gly 
        195                 200                 205             


Leu Gly Trp Thr Leu Arg Asp Tyr Val Arg Gly Tyr Ile Leu Gln Asp 
    210                 215                 220                 


Ala Ala Gly Lys Val Leu Asp Arg Trp Ala Ile Met Ser Arg Glu Glu 
225                 230                 235                 240 


Glu Ile Ile Thr Leu Gln Gln Phe Leu Arg Phe Gly Glu Thr Lys Ser 
                245                 250                 255     


Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Gly Gln Ala Val Ala 
            260                 265                 270         


Val Pro Ser Ser Lys Thr Asp Ser Asp Ile Arg Thr Phe Ile Glu Ser 
        275                 280                 285             


Asn Asn Arg Thr Arg Ser Pro Ser Leu Leu Ala His Leu Glu Asn Ser 
    290                 295                 300                 


Asn Pro Ser Ser Ile His His Phe Glu Asn Ile Pro Asn Ser Leu Ala 
305                 310                 315                 320 


Phe Leu Leu Pro Phe Gln Tyr Ile Asn Pro Val Ser Ala Pro Leu Leu 
                325                 330                 335     


Gly Leu Pro Pro Asn Gly Leu Leu Leu Glu Gln Pro Gly Leu Arg Leu 
            340                 345                 350         


Arg Glu Pro Ser Leu Ser Thr Gln Asn Glu Tyr Asn Glu Ser Ser Glu 
        355                 360                 365             


Ser Glu Val Ser Pro Thr Pro Tyr Lys Asn Asp Gln Thr Pro Asn Arg 
    370                 375                 380                 


Asn Ala Leu Thr Ser Ile Thr Asn Val Glu Pro Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Cys Val Ser Pro Ile Gln Asn Ser Ala Pro Val Ser Asp Leu Thr Lys 
                405                 410                 415     


Thr Glu His Pro Lys Ser Ser Phe Arg Ile His Arg Met Arg Arg Met 
            420                 425                 430         


Gly Ser Ala Ser Arg Lys Gly Arg Val Phe Cys Asn Ala Cys Gly Lys 
        435                 440                 445             


Thr Phe Tyr Asp Lys Gly Thr Leu Lys Ile His Tyr Asn Ala Val His 
    450                 455                 460                 


Leu Lys Ile Lys His Arg Cys Thr Ile Glu Gly Cys Asn Met Val Phe 
465                 470                 475                 480 


Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg 
                485                 490                 495     


Leu His Met Pro Met Leu Arg Asn Asn Arg Asp Lys Asp Leu Ile Arg 
            500                 505                 510         


Ala Thr Ser Gly Ala Ala Thr Pro Val Ile Ala Ser Thr Lys Ser Asn 
        515                 520                 525             


Leu Ala Leu Thr Ser Pro Gly Arg Pro Pro Met Gly Phe Thr Thr Pro 
    530                 535                 540                 


Pro Leu Asp Pro Val Leu Gln Asn Pro Leu Pro Ser Gln Leu Val Phe 
545                 550                 555                 560 


Ser Gly Leu Lys Thr Val Gln Pro Val Pro Pro Phe Tyr Arg Ser Leu 
                565                 570                 575     


Leu Thr Pro Gly Glu Met Val Ser Pro Pro Thr Ser Leu Pro Thr Ser 
            580                 585                 590         


Pro Ile Ile Pro Thr Ser Gly Thr Ile Glu Gln His Pro Pro Pro Pro 
        595                 600                 605             


Ser Glu Pro Val Val Pro Ala Val Met Met Ala Thr His Glu Pro Ser 
    610                 615                 620                 


Ala Asp Leu Ala Pro Lys Lys Lys Pro Arg Lys Ser Ser Met Pro Val 
625                 630                 635                 640 


Lys Ile Glu Lys Glu Ile Ile Asp Thr Ala Asp Glu Phe Asp Asp Glu 
                645                 650                 655     


Asp Asp Asp Pro Asn Asp Gly Gly Ala Val Val Asn Asp Met Ser His 
            660                 665                 670         


Asp Asn His Cys His Ser Gln Glu Glu Met Ser Pro Gly Met Ser Val 
        675                 680                 685             


Lys Asp Phe Ser Lys His Asn Arg Thr Arg Cys Ile Ser Arg Thr Glu 
    690                 695                 700                 


Ile Arg Arg Ala Asp Ser Met Thr Ser Glu Asp Gln Glu Pro Glu Arg 
705                 710                 715                 720 


Asp Tyr Glu Asn Glu Ser Glu Ser Ser Glu Pro Lys Leu Gly Glu Glu 
                725                 730                 735     


Ser Met Glu Gly Asp Glu His Ile His Ser Glu Val Ser Glu Lys Val 
            740                 745                 750         


Leu Met Asn Ser Glu Arg Pro Asp Glu Asn His Ser Glu Pro Ser His 
        755                 760                 765             


Gln Asp Val Ile Lys Val Lys Glu Glu Phe Thr Asp Pro Thr Tyr Asp 
    770                 775                 780                 


Met Phe Tyr Met Ser Gln Tyr Gly Leu Tyr Asn Gly Gly Gly Ala Ser 
785                 790                 795                 800 


Met Ala Ala Leu His Glu Ser Phe Thr Ser Ser Leu Asn Tyr Gly Ser 
                805                 810                 815     


Pro Gln Lys Phe Ser Pro Glu Gly Asp Leu Cys Ser Ser Pro Asp Pro 
            820                 825                 830         


Lys Ile Cys Tyr Val Cys Lys Lys Ser Phe Lys Ser Ser Tyr Ser Val 
        835                 840                 845             


Lys Leu His Tyr Arg Asn Val His Leu Lys Glu Met His Val Cys Thr 
    850                 855                 860                 


Val Ala Gly Cys Asn Ala Ala Phe Pro Ser Arg Arg Ser Arg Asp Arg 
865                 870                 875                 880 


His Ser Ala Asn Ile Asn Leu His Arg Lys Leu Leu Thr Lys Glu Leu 
                885                 890                 895     


Asp Asp Met Gly Leu Asp Ser Ser Gln Pro Ser Leu Ser Lys Asp Leu 
            900                 905                 910         


Arg Asp Glu Phe Leu Val Lys Ile Tyr Gly Ala Gln His Pro Met Gly 
        915                 920                 925             


Leu Asp Val Arg Glu Asp Ala Ser Ser Pro Ala Gly Thr Glu Asp Ser 
    930                 935                 940                 


His Leu Asn Gly Tyr Gly Arg Gly Met Ala Glu Asp Tyr Met Val Leu 
945                 950                 955                 960 


Asp Leu Ser Thr Thr Ser Ser Leu Gln Ser Ser Ser Ser Ile His Ser 
                965                 970                 975     


Ser Arg Glu Ser Asp Ala Gly Ser Asp Glu Gly Ile Leu Leu Asp Asp 
            980                 985                 990         


Ile Asp Gly Ala Ser Asp Ser Gly  Glu Ser Ala His Lys  Ala Glu Ala 
        995                 1000                 1005             


Pro Ala  Leu Pro Gly Ser Leu  Gly Ala Glu Val Ser  Gly Ser Leu 
    1010                 1015                 1020             


Met Phe  Ser Ser Leu Ser Gly  Ser Asn Gly Gly Ile  Met Cys Asn 
    1025                 1030                 1035             


Ile Cys  His Lys Met Tyr Ser  Asn Lys Gly Thr Leu  Arg Val His 
    1040                 1045                 1050             


Tyr Lys  Thr Val His Leu Arg  Glu Met His Lys Cys  Lys Val Pro 
    1055                 1060                 1065             


Gly Cys  Asn Met Met Phe Ser  Ser Val Arg Ser Arg  Asn Arg His 
    1070                 1075                 1080             


Ser Gln  Asn Pro Asn Leu His  Lys Asn Ile Pro Phe  Thr Ser Val 
    1085                 1090                 1095             


Asp 
    


<210>  1201
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNIP1__Homo_sapiens__NP_001196

<400>  1201

Met Ala Ala Pro Gln Asp Val His Val Arg Ile Cys Asn Gln Glu Ile 
1               5                   10                  15      


Val Lys Phe Asp Leu Glu Val Lys Ala Leu Ile Gln Asp Ile Arg Asp 
            20                  25                  30          


Cys Ser Gly Pro Leu Ser Ala Leu Thr Glu Leu Asn Thr Lys Val Lys 
        35                  40                  45              


Glu Lys Phe Gln Gln Leu Arg His Arg Ile Gln Asp Leu Glu Gln Leu 
    50                  55                  60                  


Ala Lys Glu Gln Asp Lys Glu Ser Glu Lys Gln Leu Leu Leu Gln Glu 
65                  70                  75                  80  


Val Glu Asn His Lys Lys Gln Met Leu Ser Asn Gln Ala Ser Trp Arg 
                85                  90                  95      


Lys Ala Asn Leu Thr Cys Lys Ile Ala Ile Asp Asn Leu Glu Lys Ala 
            100                 105                 110         


Glu Leu Leu Gln Gly Gly Asp Leu Leu Arg Gln Arg Lys Thr Thr Lys 
        115                 120                 125             


Glu Ser Leu Ala Gln Thr Ser Ser Thr Ile Thr Glu Ser Leu Met Gly 
    130                 135                 140                 


Ile Ser Arg Met Met Ala Gln Gln Val Gln Gln Ser Glu Glu Ala Met 
145                 150                 155                 160 


Gln Ser Leu Val Thr Ser Ser Arg Thr Ile Leu Asp Ala Asn Glu Glu 
                165                 170                 175     


Phe Lys Ser Met Ser Gly Thr Ile Gln Leu Gly Arg Lys Leu Ile Thr 
            180                 185                 190         


Lys Tyr Asn Arg Arg Glu Leu Thr Asp Lys Leu Leu Ile Phe Leu Ala 
        195                 200                 205             


Leu Ala Leu Phe Leu Ala Thr Val Leu Tyr Ile Val Lys Lys Arg Leu 
    210                 215                 220                 


Phe Pro Phe Leu 
225             


<210>  1202
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNIP2__Homo_sapiens__NP_004321

<400>  1202

Met Leu Cys Gly Phe Gln Glu Asp Ala Thr Pro Pro Pro Pro Pro Arg 
1               5                   10                  15      


Pro Arg Arg Leu His Arg Arg Leu Pro Arg Pro Glu Glu Val Gly Met 
            20                  25                  30          


Leu Ser Leu Pro Pro Gly Leu Leu Thr Val Ser Gly Ser Ala Ala Ala 
        35                  40                  45              


Ala Asp Ala Val Pro Leu Arg Pro Gly Asp Trp Ala Gly Val Ser Thr 
    50                  55                  60                  


Ala Asp Arg Gly Glu Arg Ala Pro Leu Gly Pro Ala Phe Cys Asp Leu 
65                  70                  75                  80  


Ala Val Ser Pro Thr Ser Pro Ala Trp Arg Gly Glu Glu Asp Glu Gly 
                85                  90                  95      


Ala Lys Ala Ser Ser Gly Asp Ile Gly Ser Leu Asp Tyr Gln Glu Phe 
            100                 105                 110         


Val Val Asp Ile Glu Ser Arg Leu Arg Met Glu Gly Val Glu Leu Lys 
        115                 120                 125             


Glu Glu Trp Gln Asp Glu Asp Phe Pro Ile Pro Leu Pro Glu Asp Asp 
    130                 135                 140                 


Ser Ile Glu Ala Asp Ile Leu Ala Ile Thr Gly Pro Glu Asp Gln Pro 
145                 150                 155                 160 


Gly Ser Leu Glu Val Asn Gly Asn Lys Val Arg Lys Lys Leu Met Ala 
                165                 170                 175     


Pro Asp Ile Ser Leu Thr Leu Asp Pro Ser Asp Gly Ser Val Leu Ser 
            180                 185                 190         


Asp Asp Leu Asp Glu Ser Gly Glu Ile Asp Leu Asp Gly Leu Asp Thr 
        195                 200                 205             


Pro Ser Glu Asn Ser Asn Glu Phe Glu Trp Glu Asp Asp Leu Pro Lys 
    210                 215                 220                 


Pro Lys Thr Thr Glu Val Ile Arg Lys Gly Ser Ile Thr Glu Tyr Thr 
225                 230                 235                 240 


Ala Ala Glu Glu Lys Glu Asp Gly Arg Arg Trp Arg Met Phe Arg Ile 
                245                 250                 255     


Gly Glu Gln Asp His Arg Val Asp Met Lys Ala Ile Glu Pro Tyr Lys 
            260                 265                 270         


Lys Val Ile Ser His Gly Gly Tyr Tyr Gly Asp Gly Leu Asn Ala Ile 
        275                 280                 285             


Val Val Phe Ala Val Cys Phe Met Pro Glu Ser Ser Gln Pro Asn Tyr 
    290                 295                 300                 


Arg Tyr Leu Met Asp Asn Leu Phe Lys Tyr Val Ile Gly Thr Leu Glu 
305                 310                 315                 320 


Leu Leu Val Ala Glu Asn Tyr Met Ile Val Tyr Leu Asn Gly Ala Thr 
                325                 330                 335     


Thr Arg Arg Lys Met Pro Ser Leu Gly Trp Leu Arg Lys Cys Tyr Gln 
            340                 345                 350         


Gln Ile Asp Arg Arg Leu Arg Lys Asn Leu Lys Ser Leu Ile Ile Val 
        355                 360                 365             


His Pro Ser Trp Phe Ile Arg Thr Leu Leu Ala Val Thr Arg Pro Phe 
    370                 375                 380                 


Ile Ser Ser Lys Phe Ser Gln Lys Ile Arg Tyr Val Phe Asn Leu Ala 
385                 390                 395                 400 


Glu Leu Ala Glu Leu Val Pro Met Glu Tyr Val Gly Ile Pro Glu Cys 
                405                 410                 415     


Ile Lys Gln Val Asp Gln Glu Leu Asn Gly Lys Gln Asp Glu Pro Lys 
            420                 425                 430         


Asn Glu Gln 
        435 


<210>  1203
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNIP3__Homo_sapiens__NP_004043

<400>  1203

Met Gly Asp Ala Ala Ala Asp Pro Pro Gly Pro Ala Leu Pro Cys Glu 
1               5                   10                  15      


Phe Leu Arg Pro Gly Cys Gly Ala Pro Leu Ser Pro Gly Ala Gln Leu 
            20                  25                  30          


Gly Arg Gly Ala Pro Thr Ser Ala Phe Pro Pro Pro Ala Ala Glu Ala 
        35                  40                  45              


His Pro Ala Ala Arg Arg Gly Leu Arg Ser Pro Gln Leu Pro Ser Gly 
    50                  55                  60                  


Ala Met Ser Gln Asn Gly Ala Pro Gly Met Gln Glu Glu Ser Leu Gln 
65                  70                  75                  80  


Gly Ser Trp Val Glu Leu His Phe Ser Asn Asn Gly Asn Gly Gly Ser 
                85                  90                  95      


Val Pro Ala Ser Val Ser Ile Tyr Asn Gly Asp Met Glu Lys Ile Leu 
            100                 105                 110         


Leu Asp Ala Gln His Glu Ser Gly Arg Ser Ser Ser Lys Ser Ser His 
        115                 120                 125             


Cys Asp Ser Pro Pro Arg Ser Gln Thr Pro Gln Asp Thr Asn Arg Ala 
    130                 135                 140                 


Ser Glu Thr Asp Thr His Ser Ile Gly Glu Lys Asn Ser Ser Gln Ser 
145                 150                 155                 160 


Glu Glu Asp Asp Ile Glu Arg Arg Lys Glu Val Glu Ser Ile Leu Lys 
                165                 170                 175     


Lys Asn Ser Asp Trp Ile Trp Asp Trp Ser Ser Arg Pro Glu Asn Ile 
            180                 185                 190         


Pro Pro Lys Glu Phe Leu Phe Lys His Pro Lys Arg Thr Ala Thr Leu 
        195                 200                 205             


Ser Met Arg Asn Thr Ser Val Met Lys Lys Gly Gly Ile Phe Ser Ala 
    210                 215                 220                 


Glu Phe Leu Lys Val Phe Leu Pro Ser Leu Leu Leu Ser His Leu Leu 
225                 230                 235                 240 


Ala Ile Gly Leu Gly Ile Tyr Ile Gly Arg Arg Leu Thr Thr Ser Thr 
                245                 250                 255     


Ser Thr Phe 
            


<210>  1204
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNIP3L__Homo_sapiens__NP_004322

<400>  1204

Met Ser Ser His Leu Val Glu Pro Pro Pro Pro Leu His Asn Asn Asn 
1               5                   10                  15      


Asn Asn Cys Glu Glu Asn Glu Gln Ser Leu Pro Pro Pro Ala Gly Leu 
            20                  25                  30          


Asn Ser Ser Trp Val Glu Leu Pro Met Asn Ser Ser Asn Gly Asn Asp 
        35                  40                  45              


Asn Gly Asn Gly Lys Asn Gly Gly Leu Glu His Val Pro Ser Ser Ser 
    50                  55                  60                  


Ser Ile His Asn Gly Asp Met Glu Lys Ile Leu Leu Asp Ala Gln His 
65                  70                  75                  80  


Glu Ser Gly Gln Ser Ser Ser Arg Gly Ser Ser His Cys Asp Ser Pro 
                85                  90                  95      


Ser Pro Gln Glu Asp Gly Gln Ile Met Phe Asp Val Glu Met His Thr 
            100                 105                 110         


Ser Arg Asp His Ser Ser Gln Ser Glu Glu Glu Val Val Glu Gly Glu 
        115                 120                 125             


Lys Glu Val Glu Ala Leu Lys Lys Ser Ala Asp Trp Val Ser Asp Trp 
    130                 135                 140                 


Ser Ser Arg Pro Glu Asn Ile Pro Pro Lys Glu Phe His Phe Arg His 
145                 150                 155                 160 


Pro Lys Arg Ser Val Ser Leu Ser Met Arg Lys Ser Gly Ala Met Lys 
                165                 170                 175     


Lys Gly Gly Ile Phe Ser Ala Glu Phe Leu Lys Val Phe Ile Pro Ser 
            180                 185                 190         


Leu Phe Leu Ser His Val Leu Ala Leu Gly Leu Gly Ile Tyr Ile Gly 
        195                 200                 205             


Lys Arg Leu Ser Thr Pro Ser Ala Ser Thr Tyr 
    210                 215                 


<210>  1205
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BNIPL__Homo_sapiens__XP_011507538

<400>  1205

Met Gly Thr Ile Gln Glu Ala Gly Lys Lys Thr Asp Val Gly Val Arg 
1               5                   10                  15      


Glu Ile Ala Glu Ala Pro Glu Leu Gly Ala Ala Leu Arg His Gly Glu 
            20                  25                  30          


Leu Glu Leu Lys Glu Glu Trp Gln Asp Glu Glu Phe Pro Arg Leu Leu 
        35                  40                  45              


Pro Glu Glu Ala Gly Thr Ser Glu Asp Pro Glu Asp Pro Lys Gly Asp 
    50                  55                  60                  


Ser Gln Ala Ala Ala Gly Thr Pro Ser Thr Leu Ala Leu Cys Gly Gln 
65                  70                  75                  80  


Arg Pro Met Arg Lys Arg Leu Ser Ala Pro Glu Leu Arg Leu Ser Leu 
                85                  90                  95      


Thr Lys Gly Pro Gly Asn Asp Gly Ala Ser Pro Thr Gln Ser Ala Pro 
            100                 105                 110         


Ser Ser Pro Asp Gly Ser Ser Asp Leu Glu Ile Asp Glu Leu Glu Thr 
        115                 120                 125             


Pro Ser Asp Ser Glu Gln Leu Asp Ser Gly His Glu Phe Glu Trp Glu 
    130                 135                 140                 


Asp Glu Leu Pro Arg Ala Glu Gly Leu Gly Thr Ser Glu Thr Ala Glu 
145                 150                 155                 160 


Arg Leu Gly Arg Gly Cys Met Trp Asp Val Thr Gly Glu Asp Gly His 
                165                 170                 175     


His Trp Arg Val Phe Arg Met Gly Pro Arg Glu Gln Arg Val Asp Met 
            180                 185                 190         


Thr Val Ile Glu Pro Tyr Lys Lys Val Leu Ser His Gly Gly Tyr His 
        195                 200                 205             


Gly Asp Gly Leu Asn Ala Val Ile Leu Phe Ala Ser Cys Tyr Leu Pro 
    210                 215                 220                 


Arg Ser Ser Ile Pro Asn Tyr Thr Tyr Val Met Glu His Leu Phe Arg 
225                 230                 235                 240 


Tyr Met Val Gly Thr Leu Glu Leu Leu Val Ala Glu Asn Tyr Leu Leu 
                245                 250                 255     


Val His Leu Ser Gly Gly Thr Ser Arg Ala Gln Val Pro Pro Leu Ser 
            260                 265                 270         


Trp Ile Arg Gln Cys Tyr Arg Thr Leu Asp Arg Arg Leu Arg Lys Asn 
        275                 280                 285             


Leu Arg Ala Leu Val Val Val His Ala Thr Cys Ser Lys Phe Thr Arg 
    290                 295                 300                 


Lys Ile Arg Phe Leu Asp Ser Leu Gly Glu Leu Ala Gln Leu Ile Ser 
305                 310                 315                 320 


Leu Asp Gln Val His Ile Pro Glu Ala Val Arg Gln Leu Asp Arg Asp 
                325                 330                 335     


Leu His Gly Ser Gly Gly Thr 
            340             


<210>  1206
<211>  1115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BOC__Homo_sapiens__NP_001288790

<400>  1206

Met Leu Arg Gly Thr Met Thr Ala Trp Arg Gly Met Arg Pro Glu Val 
1               5                   10                  15      


Thr Leu Ala Cys Leu Leu Leu Ala Thr Ala Gly Cys Phe Ala Asp Leu 
            20                  25                  30          


Asn Glu Val Pro Gln Val Thr Val Gln Pro Ala Ser Thr Val Gln Lys 
        35                  40                  45              


Pro Gly Gly Thr Val Ile Leu Gly Cys Val Val Glu Pro Pro Arg Met 
    50                  55                  60                  


Asn Val Thr Trp Arg Leu Asn Gly Lys Glu Leu Asn Gly Ser Asp Asp 
65                  70                  75                  80  


Ala Leu Gly Val Leu Ile Thr His Gly Thr Leu Val Ile Thr Ala Leu 
                85                  90                  95      


Asn Asn His Thr Val Gly Arg Tyr Gln Cys Val Ala Arg Met Pro Ala 
            100                 105                 110         


Gly Ala Val Ala Ser Val Pro Ala Thr Val Thr Leu Ala Asn Leu Gln 
        115                 120                 125             


Asp Phe Lys Leu Asp Val Gln His Val Ile Glu Val Asp Glu Gly Asn 
    130                 135                 140                 


Thr Ala Val Ile Ala Cys His Leu Pro Glu Ser His Pro Lys Ala Gln 
145                 150                 155                 160 


Val Arg Tyr Ser Val Lys Gln Glu Trp Leu Glu Ala Ser Arg Gly Asn 
                165                 170                 175     


Tyr Leu Ile Met Pro Ser Gly Asn Leu Gln Ile Val Asn Ala Ser Gln 
            180                 185                 190         


Glu Asp Glu Gly Met Tyr Lys Cys Ala Ala Tyr Asn Pro Val Thr Gln 
        195                 200                 205             


Glu Val Lys Thr Ser Gly Ser Ser Asp Arg Leu Arg Val Arg Arg Ser 
    210                 215                 220                 


Thr Ala Glu Ala Ala Arg Ile Ile Tyr Pro Pro Glu Ala Gln Thr Ile 
225                 230                 235                 240 


Ile Val Thr Lys Gly Gln Ser Leu Ile Leu Glu Cys Val Ala Ser Gly 
                245                 250                 255     


Ile Pro Pro Pro Arg Val Thr Trp Ala Lys Asp Gly Ser Ser Val Thr 
            260                 265                 270         


Gly Tyr Asn Lys Thr Arg Phe Leu Leu Ser Asn Leu Leu Ile Asp Thr 
        275                 280                 285             


Thr Ser Glu Glu Asp Ser Gly Thr Tyr Arg Cys Met Ala Asp Asn Gly 
    290                 295                 300                 


Val Gly Gln Pro Gly Ala Ala Val Ile Leu Tyr Asn Val Gln Val Phe 
305                 310                 315                 320 


Glu Pro Pro Glu Val Thr Met Glu Leu Ser Gln Leu Val Ile Pro Trp 
                325                 330                 335     


Gly Gln Ser Ala Lys Leu Thr Cys Glu Val Arg Gly Asn Pro Pro Pro 
            340                 345                 350         


Ser Val Leu Trp Leu Arg Asn Ala Val Pro Leu Ile Ser Ser Gln Arg 
        355                 360                 365             


Leu Arg Leu Ser Arg Arg Ala Leu Arg Val Leu Ser Met Gly Pro Glu 
    370                 375                 380                 


Asp Glu Gly Val Tyr Gln Cys Met Ala Glu Asn Glu Val Gly Ser Ala 
385                 390                 395                 400 


His Ala Val Val Gln Leu Arg Thr Ser Arg Pro Ser Ile Thr Pro Arg 
                405                 410                 415     


Leu Trp Gln Asp Ala Glu Leu Ala Thr Gly Thr Pro Pro Val Ser Pro 
            420                 425                 430         


Ser Lys Leu Gly Asn Pro Glu Gln Met Leu Arg Gly Gln Pro Ala Leu 
        435                 440                 445             


Pro Arg Pro Pro Thr Ser Val Gly Pro Ala Ser Pro Gln Cys Pro Gly 
    450                 455                 460                 


Glu Lys Gly Gln Gly Ala Pro Ala Glu Ala Pro Ile Ile Leu Ser Ser 
465                 470                 475                 480 


Pro Arg Thr Ser Lys Thr Asp Ser Tyr Glu Leu Val Trp Arg Pro Arg 
                485                 490                 495     


His Glu Gly Ser Gly Arg Ala Pro Ile Leu Tyr Tyr Val Val Lys His 
            500                 505                 510         


Arg Lys Gln Val Thr Asn Ser Ser Asp Asp Trp Thr Ile Ser Gly Ile 
        515                 520                 525             


Pro Ala Asn Gln His Arg Leu Thr Leu Thr Arg Leu Asp Pro Gly Ser 
    530                 535                 540                 


Leu Tyr Glu Val Glu Met Ala Ala Tyr Asn Cys Ala Gly Glu Gly Gln 
545                 550                 555                 560 


Thr Ala Met Val Thr Phe Arg Thr Gly Arg Arg Pro Lys Pro Glu Ile 
                565                 570                 575     


Met Ala Ser Lys Glu Gln Gln Ile Gln Arg Asp Asp Pro Gly Ala Ser 
            580                 585                 590         


Pro Gln Ser Ser Ser Gln Pro Asp His Gly Arg Leu Ser Pro Pro Glu 
        595                 600                 605             


Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser Val Tyr 
    610                 615                 620                 


Val Thr Trp Ile Pro Arg Gly Asn Gly Gly Phe Pro Ile Gln Ser Phe 
625                 630                 635                 640 


Arg Val Glu Tyr Lys Lys Leu Lys Lys Val Gly Asp Trp Ile Leu Ala 
                645                 650                 655     


Thr Ser Ala Ile Pro Pro Ser Arg Leu Ser Val Glu Ile Thr Gly Leu 
            660                 665                 670         


Glu Lys Gly Thr Ser Tyr Lys Phe Arg Val Arg Ala Leu Asn Met Leu 
        675                 680                 685             


Gly Glu Ser Glu Pro Ser Ala Pro Ser Arg Pro Tyr Val Val Ser Gly 
    690                 695                 700                 


Tyr Ser Gly Arg Val Tyr Glu Arg Pro Val Ala Gly Pro Tyr Ile Thr 
705                 710                 715                 720 


Phe Thr Asp Ala Val Asn Glu Thr Thr Ile Met Leu Lys Trp Met Tyr 
                725                 730                 735     


Ile Pro Ala Ser Asn Asn Asn Thr Pro Ile His Gly Phe Tyr Ile Tyr 
            740                 745                 750         


Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Lys Asp Met 
        755                 760                 765             


Val Glu Gly Asp Lys Tyr Trp His Ser Ile Ser His Leu Gln Pro Glu 
    770                 775                 780                 


Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu Ser 
785                 790                 795                 800 


Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Ala Arg Lys Ser Ser 
                805                 810                 815     


Gly Gln Pro Gly Arg Leu Pro Pro Pro Thr Leu Ala Pro Pro Gln Pro 
            820                 825                 830         


Pro Leu Pro Glu Thr Ile Glu Arg Pro Val Gly Thr Gly Ala Met Val 
        835                 840                 845             


Ala Arg Ser Ser Asp Leu Pro Tyr Leu Ile Val Gly Val Val Leu Gly 
    850                 855                 860                 


Ser Ile Val Leu Ile Ile Val Thr Phe Ile Pro Phe Cys Leu Trp Arg 
865                 870                 875                 880 


Ala Trp Ser Lys Gln Lys His Thr Thr Asp Leu Gly Phe Pro Arg Ser 
                885                 890                 895     


Ala Leu Pro Pro Ser Cys Pro Tyr Thr Met Val Pro Leu Gly Gly Leu 
            900                 905                 910         


Pro Gly His Gln Ala Ser Gly Gln Pro Tyr Leu Ser Gly Ile Ser Gly 
        915                 920                 925             


Arg Ala Cys Ala Asn Gly Ile His Met Asn Arg Gly Cys Pro Ser Ala 
    930                 935                 940                 


Ala Val Gly Tyr Pro Gly Met Lys Pro Gln Gln His Cys Pro Gly Glu 
945                 950                 955                 960 


Leu Gln Gln Gln Ser Asp Thr Ser Ser Leu Leu Arg Gln Thr His Leu 
                965                 970                 975     


Gly Asn Gly Tyr Asp Pro Gln Ser His Gln Ile Thr Arg Gly Pro Lys 
            980                 985                 990         


Ser Ser Pro Asp Glu Gly Ser Phe  Leu Tyr Thr Leu Pro  Asp Asp Ser 
        995                 1000                 1005             


Thr His  Gln Leu Leu Gln Pro  His His Asp Cys Cys  Gln Arg Gln 
    1010                 1015                 1020             


Glu Gln  Pro Ala Ala Val Gly  Gln Ser Gly Val Arg  Arg Ala Pro 
    1025                 1030                 1035             


Asp Ser  Pro Val Leu Glu Ala  Val Trp Asp Pro Pro  Phe His Ser 
    1040                 1045                 1050             


Gly Pro  Pro Cys Cys Leu Gly  Leu Val Pro Val Glu  Glu Val Asp 
    1055                 1060                 1065             


Ser Pro  Asp Ser Cys Gln Val  Ser Gly Gly Asp Trp  Cys Pro Gln 
    1070                 1075                 1080             


His Pro  Val Gly Ala Tyr Val  Gly Gln Glu Pro Gly  Met Gln Leu 
    1085                 1090                 1095             


Ser Pro  Gly Pro Leu Val Arg  Val Ser Phe Glu Thr  Pro Pro Leu 
    1100                 1105                 1110             


Thr Ile  
    1115 


<210>  1207
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BOD1L2__Homo_sapiens__NP_001244893

<400>  1207

Met Ala Asp Gly Gly Gly Gly Gly Ser Gly Gly Ala Gly Pro Ala Ser 
1               5                   10                  15      


Thr Arg Ala Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro 
            20                  25                  30          


Pro Gly Asp Pro Gln Leu Ile Ala Ile Ile Val Gly Gln Leu Lys Ser 
        35                  40                  45              


Arg Gly Leu Phe Asp Ser Phe Arg Arg Asp Cys Lys Ala Asp Val Asp 
    50                  55                  60                  


Thr Lys Pro Ala Tyr Gln Asn Leu Ser Gln Lys Ala Asp Asn Phe Val 
65                  70                  75                  80  


Ser Thr His Leu Asp Lys Gln Glu Trp Asn Pro Pro Ala Asn Asp Asn 
                85                  90                  95      


Gln Leu His Asp Gly Leu Arg Gln Ser Val Val Gln Ser Gly Arg Ser 
            100                 105                 110         


Glu Ala Gly Val Asp Arg Ile Ser Ser Gln Val Val Asp Pro Lys Leu 
        115                 120                 125             


Asn His Ile Phe Arg Pro Gln Ile Glu Gln Ile Ile His Glu Phe Leu 
    130                 135                 140                 


Val Ala Gln Lys Glu Ala Ala Val Pro Ala Leu Pro Pro Glu Pro Glu 
145                 150                 155                 160 


Gly Gln Asp Pro Pro Ala Pro Ser Gln Asp Thr Ser 
                165                 170         


<210>  1208
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BOK__Homo_sapiens__NP_115904

<400>  1208

Met Glu Val Leu Arg Arg Ser Ser Val Phe Ala Ala Glu Ile Met Asp 
1               5                   10                  15      


Ala Phe Asp Arg Ser Pro Thr Asp Lys Glu Leu Val Ala Gln Ala Lys 
            20                  25                  30          


Ala Leu Gly Arg Glu Tyr Val His Ala Arg Leu Leu Arg Ala Gly Leu 
        35                  40                  45              


Ser Trp Ser Ala Pro Glu Arg Ala Ala Pro Val Pro Gly Arg Leu Ala 
    50                  55                  60                  


Glu Val Cys Ala Val Leu Leu Arg Leu Gly Asp Glu Leu Glu Met Ile 
65                  70                  75                  80  


Arg Pro Ser Val Tyr Arg Asn Val Ala Arg Gln Leu His Ile Ser Leu 
                85                  90                  95      


Gln Ser Glu Pro Val Val Thr Asp Ala Phe Leu Ala Val Ala Gly His 
            100                 105                 110         


Ile Phe Ser Ala Gly Ile Thr Trp Gly Lys Val Val Ser Leu Tyr Ala 
        115                 120                 125             


Val Ala Ala Gly Leu Ala Val Asp Cys Val Arg Gln Ala Gln Pro Ala 
    130                 135                 140                 


Met Val His Ala Leu Val Asp Cys Leu Gly Glu Phe Val Arg Lys Thr 
145                 150                 155                 160 


Leu Ala Thr Trp Leu Arg Arg Arg Gly Gly Trp Thr Asp Val Leu Lys 
                165                 170                 175     


Cys Val Val Ser Thr Asp Pro Gly Leu Arg Ser His Trp Leu Val Ala 
            180                 185                 190         


Ala Leu Cys Ser Phe Gly Arg Phe Leu Lys Ala Ala Phe Phe Val Leu 
        195                 200                 205             


Leu Pro Glu Arg 
    210         


<210>  1209
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BOLA3__Homo_sapiens__NP_001030582

<400>  1209

Met Ala Ala Trp Ser Pro Ala Ala Ala Ala Pro Leu Leu Arg Gly Ile 
1               5                   10                  15      


Arg Gly Leu Pro Leu His His Arg Met Phe Ala Thr Gln Thr Glu Gly 
            20                  25                  30          


Glu Leu Arg Val Thr Gln Ile Leu Lys Glu Lys Phe Pro Arg Ala Thr 
        35                  40                  45              


Ala Ile Lys Val Thr Asp Ile Ser Gly Thr Lys Arg Arg Asn Gln Arg 
    50                  55                  60                  


Asp Ala Trp Ile Ala Asp Ile Tyr Leu Cys Pro Gln Thr Leu Thr Thr 
65                  70                  75                  80  


Pro Trp Leu His Arg Cys Cys Cys Leu Arg Pro Trp Met Asn Phe Thr 
                85                  90                  95      


Asp Ile Ile Leu Pro 
            100     


<210>  1210
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BOLL__Homo_sapiens__NP_001271287

<400>  1210

Met Thr Glu Leu Glu Tyr Pro Lys Gly Ser Ser Ile Met Pro Ala Ala 
1               5                   10                  15      


Gly Thr Met Tyr Leu Thr Thr Ser Thr Gly Tyr Pro Tyr Thr Tyr His 
            20                  25                  30          


Asn Gly Val Ala Tyr Phe His Thr Pro Glu Val Thr Ser Val Pro Pro 
        35                  40                  45              


Pro Trp Pro Ser Arg Ser Val Cys Ser Ser Pro Val Met Val Ala Gln 
    50                  55                  60                  


Pro Ile Tyr Gln Gln Pro Ala Tyr His Tyr Gln Ala Thr Thr Gln Tyr 
65                  70                  75                  80  


Leu Pro Gly Gln Trp Gln Trp Ser Val Pro Gln Pro Ser Ala Ser Ser 
                85                  90                  95      


Ala Pro Phe Leu Tyr Leu Gln Pro Ser Glu Val Ile Tyr Gln Pro Val 
            100                 105                 110         


Glu Ile Ala Gln Asp Gly Gly Cys Val Pro Pro Pro Leu Ser Leu Met 
        115                 120                 125             


Glu Thr Ser Val Pro Glu Pro Tyr Ser Asp His Gly Val Gln Ala Thr 
    130                 135                 140                 


Tyr His Gln Val Tyr Ala Pro Ser Ala Ile Thr Met Pro Ala Pro Val 
145                 150                 155                 160 


Met Gln Pro Glu Pro Ile Lys Thr Val Trp Ser Ile His Tyr 
                165                 170                 


<210>  1211
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BOP1__Homo_sapiens__NP_056016

<400>  1211

Met Ala Gly Ser Arg Gly Ala Gly Arg Thr Ala Ala Pro Ser Val Arg 
1               5                   10                  15      


Pro Glu Lys Arg Arg Ser Glu Pro Glu Leu Glu Pro Glu Pro Glu Pro 
            20                  25                  30          


Glu Pro Pro Leu Leu Cys Thr Ser Pro Leu Ser His Ser Thr Gly Ser 
        35                  40                  45              


Asp Ser Gly Val Ser Asp Ser Glu Glu Ser Val Phe Ser Gly Leu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Asp Ser Ser Glu Asp Asp Asp Glu Gly Asp Glu Glu 
65                  70                  75                  80  


Gly Glu Asp Gly Ala Leu Asp Asp Glu Gly His Ser Gly Ile Lys Lys 
                85                  90                  95      


Thr Thr Glu Glu Gln Val Gln Ala Ser Thr Pro Cys Pro Arg Thr Glu 
            100                 105                 110         


Met Ala Ser Ala Arg Ile Gly Asp Glu Tyr Ala Glu Asp Ser Ser Asp 
        115                 120                 125             


Glu Glu Asp Ile Arg Asn Thr Val Gly Asn Val Pro Leu Glu Trp Tyr 
    130                 135                 140                 


Asp Asp Phe Pro His Val Gly Tyr Asp Leu Asp Gly Arg Arg Ile Tyr 
145                 150                 155                 160 


Lys Pro Leu Arg Thr Arg Asp Glu Leu Asp Gln Phe Leu Asp Lys Met 
                165                 170                 175     


Asp Asp Pro Asp Tyr Trp Arg Thr Val Gln Asp Pro Met Thr Gly Arg 
            180                 185                 190         


Asp Leu Arg Leu Thr Asp Glu Gln Val Ala Leu Val Arg Arg Leu Gln 
        195                 200                 205             


Ser Gly Gln Phe Gly Asp Val Gly Phe Asn Pro Tyr Glu Pro Ala Val 
    210                 215                 220                 


Asp Phe Phe Ser Gly Asp Val Met Ile His Pro Val Thr Asn Arg Pro 
225                 230                 235                 240 


Ala Asp Lys Arg Ser Phe Ile Pro Ser Leu Val Glu Lys Glu Lys Val 
                245                 250                 255     


Ser Arg Met Val His Ala Ile Lys Met Gly Trp Ile Gln Pro Arg Arg 
            260                 265                 270         


Pro Arg Asp Pro Thr Pro Ser Phe Tyr Asp Leu Trp Ala Gln Glu Asp 
        275                 280                 285             


Pro Asn Ala Val Leu Gly Arg His Lys Met His Val Pro Ala Pro Lys 
    290                 295                 300                 


Leu Ala Leu Pro Gly His Ala Glu Ser Tyr Asn Pro Pro Pro Glu Tyr 
305                 310                 315                 320 


Leu Leu Ser Glu Glu Glu Arg Leu Ala Trp Glu Gln Gln Glu Pro Gly 
                325                 330                 335     


Glu Arg Lys Leu Ser Phe Leu Pro Arg Lys Phe Pro Ser Leu Arg Ala 
            340                 345                 350         


Val Pro Ala Tyr Gly Arg Phe Ile Gln Glu Arg Phe Glu Arg Cys Leu 
        355                 360                 365             


Asp Leu Tyr Leu Cys Pro Arg Gln Arg Lys Met Arg Val Asn Val Asp 
    370                 375                 380                 


Pro Glu Asp Leu Ile Pro Lys Leu Pro Arg Pro Arg Asp Leu Gln Pro 
385                 390                 395                 400 


Phe Pro Thr Cys Gln Ala Leu Val Tyr Arg Gly His Ser Asp Leu Val 
                405                 410                 415     


Arg Cys Leu Ser Val Ser Pro Gly Gly Gln Trp Leu Val Ser Gly Ser 
            420                 425                 430         


Asp Asp Gly Ser Leu Arg Leu Trp Glu Val Ala Thr Ala Arg Cys Val 
        435                 440                 445             


Arg Thr Val Pro Val Gly Gly Val Val Lys Ser Val Ala Trp Asn Pro 
    450                 455                 460                 


Ser Pro Ala Val Cys Leu Val Ala Ala Ala Val Glu Asp Ser Val Leu 
465                 470                 475                 480 


Leu Leu Asn Pro Ala Leu Gly Asp Arg Leu Val Ala Gly Ser Thr Asp 
                485                 490                 495     


Gln Leu Leu Ser Ala Phe Val Pro Pro Glu Glu Pro Pro Leu Gln Pro 
            500                 505                 510         


Ala Arg Trp Leu Glu Ala Ser Glu Glu Glu Arg Gln Val Gly Leu Arg 
        515                 520                 525             


Leu Arg Ile Cys His Gly Lys Pro Val Thr Gln Val Thr Trp His Gly 
    530                 535                 540                 


Arg Gly Asp Tyr Leu Ala Val Val Leu Ala Thr Gln Gly His Thr Gln 
545                 550                 555                 560 


Val Leu Ile His Gln Leu Ser Arg Arg Arg Ser Gln Ser Pro Phe Arg 
                565                 570                 575     


Arg Ser His Gly Gln Val Gln Arg Val Ala Phe His Pro Ala Arg Pro 
            580                 585                 590         


Phe Leu Leu Val Ala Ser Gln Arg Ser Val Arg Leu Tyr His Leu Leu 
        595                 600                 605             


Arg Gln Glu Leu Thr Lys Lys Leu Met Pro Asn Cys Lys Trp Val Ser 
    610                 615                 620                 


Ser Leu Ala Val His Pro Ala Gly Asp Asn Val Ile Cys Gly Ser Tyr 
625                 630                 635                 640 


Asp Ser Lys Leu Val Trp Phe Asp Leu Asp Leu Ser Thr Lys Pro Tyr 
                645                 650                 655     


Arg Met Leu Arg His His Lys Lys Ala Leu Arg Ala Val Ala Phe His 
            660                 665                 670         


Pro Arg Tyr Pro Leu Phe Ala Ser Gly Ser Asp Asp Gly Ser Val Ile 
        675                 680                 685             


Val Cys His Gly Met Val Tyr Asn Asp Leu Leu Gln Asn Pro Leu Leu 
    690                 695                 700                 


Val Pro Val Lys Val Leu Lys Gly His Val Leu Thr Arg Asp Leu Gly 
705                 710                 715                 720 


Val Leu Asp Val Ile Phe His Pro Thr Gln Pro Trp Val Phe Ser Ser 
                725                 730                 735     


Gly Ala Asp Gly Thr Val Arg Leu Phe Thr 
            740                 745     


<210>  1212
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BORA__Homo_sapiens__NP_001273675

<400>  1212

Met Glu Arg Phe Leu Phe Pro Ala Pro Asp Leu Pro Ala Arg Ser Pro 
1               5                   10                  15      


Leu Val Asn Gly Ser Ser Gln Gly Val Gly Val Glu Glu Arg Gly Thr 
            20                  25                  30          


Arg Lys Ser Gly His Val Gly Leu Gly Ala Thr Pro Pro Ser His Ser 
        35                  40                  45              


Ile Gln Gly Ser Arg Leu His Leu Asn Leu Pro Glu Val Asp Ser Phe 
    50                  55                  60                  


Pro Pro His Pro Ala Lys Phe Ser Leu Cys Ala Met Gly Asp Val Lys 
65                  70                  75                  80  


Glu Ser Lys Met Gln Ile Thr Pro Glu Thr Pro Gly Arg Ile Pro Val 
                85                  90                  95      


Leu Asn Pro Phe Glu Ser Pro Ser Asp Tyr Ser Asn Leu His Glu Gln 
            100                 105                 110         


Thr Leu Ala Ser Pro Ser Val Phe Lys Ser Thr Lys Leu Pro Thr Pro 
        115                 120                 125             


Gly Lys Phe Arg Trp Ser Ile Asp Gln Leu Ala Val Ile Asn Pro Val 
    130                 135                 140                 


Glu Ile Asp Pro Glu Asp Ile His Arg Gln Ala Leu Tyr Leu Ser His 
145                 150                 155                 160 


Ser Arg Ile Asp Lys Asp Val Glu Asp Lys Arg Gln Lys Ala Ile Glu 
                165                 170                 175     


Glu Phe Phe Thr Lys Asp Val Ile Val Pro Ser Pro Trp Thr Asp His 
            180                 185                 190         


Glu Gly Lys Gln Leu Ser Gln Cys His Ser Ser Lys Cys Thr Asn Ile 
        195                 200                 205             


Asn Ser Asp Ser Pro Val Gly Lys Lys Leu Thr Ile His Ser Glu Lys 
    210                 215                 220                 


Ser Asp Ala Ala Cys Gln Thr Leu Leu Ser Leu Pro Val Asp Phe Asn 
225                 230                 235                 240 


Leu Glu Asn Ile Leu Gly Asp Tyr Phe Arg Ala Asp Glu Phe Ala Asp 
                245                 250                 255     


Gln Ser Pro Gly Asn Leu Ser Ser Ser Ser Leu Arg Arg Lys Leu Phe 
            260                 265                 270         


Leu Asp Gly Asn Gly Ser Ile Ser Asp Ser Leu Pro Ser Ala Ser Pro 
        275                 280                 285             


Gly Ser Pro His Ser Gly Val Gln Thr Ser Leu Glu Met Phe Tyr Ser 
    290                 295                 300                 


Ile Asp Leu Ser Pro Val Lys Cys Arg Ser Pro Leu Gln Thr Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Phe Ser Ser Ser Pro Ile Gln Ala Ser Ala Lys Lys Tyr 
                325                 330                 335     


Ser Leu Gly Ser Ile Thr Ser Pro Ser Pro Ile Ser Ser Pro Thr Phe 
            340                 345                 350         


Ser Pro Ile Glu Phe Gln Ile Gly Glu Thr Pro Leu Ser Glu Gln Arg 
        355                 360                 365             


Lys Phe Thr Val His Ser Pro Asp Ala Ser Ser Gly Thr Asn Ser Asn 
    370                 375                 380                 


Gly Ile Thr Asn Pro Cys Ile Arg Ser Pro Tyr Ile Asp Gly Cys Ser 
385                 390                 395                 400 


Pro Ile Lys Asn Trp Ser Pro Met Arg Leu Gln Met Tyr Ser Gly Gly 
                405                 410                 415     


Thr Gln Tyr Arg Thr Ser Val Ile Gln Ile Pro Phe Thr Leu Glu Thr 
            420                 425                 430         


Gln Gly Glu Asp Glu Glu Asp Lys Glu Asn Ile Pro Ser Thr Asp Val 
        435                 440                 445             


Ser Ser Pro Ala Met Asp Ala Ala Gly Ile His Leu Arg Gln Phe Ser 
    450                 455                 460                 


Asn Glu Ala Ser Thr His Gly Thr His Leu Val Val Thr Ala Met Ser 
465                 470                 475                 480 


Val Thr Gln Asn Gln Ser Ser Ala Ser Glu Lys Glu Leu Ala Leu Leu 
                485                 490                 495     


Gln Asp Val Glu Arg Glu Lys Asp Asn Asn Thr Val Asp Met Val Asp 
            500                 505                 510         


Pro Ile Glu Ile Ala Asp Glu Thr Thr Trp Ile Lys Glu Pro Val Asp 
        515                 520                 525             


Asn Gly Ser Leu Pro Met Thr Asp Phe Val Ser Gly Ile Ala Phe Ser 
    530                 535                 540                 


Ile Glu Asn Ser His Met Cys Met Ser Pro Leu Ala Glu Ser Ser Val 
545                 550                 555                 560 


Ile Pro Cys Glu Ser Ser Asn Ile Gln Met Asp Ser Gly Tyr Asn Thr 
                565                 570                 575     


Gln Asn Cys Gly Ser Asn Ile Met Asp Thr Val Gly Ala Glu Ser Tyr 
            580                 585                 590         


Cys Lys Glu Ser Asp Ala Gln Thr Cys Glu Val Glu Ser Lys Ser Gln 
        595                 600                 605             


Ala Phe Asn Met Lys Gln Asp His Thr Thr Gln Arg Cys Trp Met Lys 
    610                 615                 620                 


Thr Ala Ser Pro Phe Gln Cys Ser Ser Pro 
625                 630                 


<210>  1213
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPGM__Homo_sapiens__NP_001280014

<400>  1213

Met Ser Lys Tyr Lys Leu Ile Met Leu Arg His Gly Glu Gly Ala Trp 
1               5                   10                  15      


Asn Lys Glu Asn Arg Phe Cys Ser Trp Val Asp Gln Lys Leu Asn Ser 
            20                  25                  30          


Glu Gly Met Glu Glu Ala Arg Asn Cys Gly Lys Gln Leu Lys Ala Leu 
        35                  40                  45              


Asn Phe Glu Phe Asp Leu Val Phe Thr Ser Val Leu Asn Arg Ser Ile 
    50                  55                  60                  


His Thr Ala Trp Leu Ile Leu Glu Glu Leu Gly Gln Glu Trp Val Pro 
65                  70                  75                  80  


Val Glu Ser Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Ile 
                85                  90                  95      


Gly Leu Asn Arg Glu Gln Met Ala Leu Asn His Gly Glu Glu Gln Val 
            100                 105                 110         


Arg Leu Trp Arg Arg Ser Tyr Asn Val Thr Pro Pro Pro Ile Glu Glu 
        115                 120                 125             


Ser His Pro Tyr Tyr Gln Glu Ile Tyr Asn Asp Arg Arg Tyr Lys Val 
    130                 135                 140                 


Cys Asp Val Pro Leu Asp Gln Leu Pro Arg Ser Glu Ser Leu Lys Asp 
145                 150                 155                 160 


Val Leu Glu Arg Leu Leu Pro Tyr Trp Asn Glu Arg Ile Ala Pro Glu 
                165                 170                 175     


Val Leu Arg Gly Lys Thr Ile Leu Ile Ser Ala His Gly Asn Ser Ser 
            180                 185                 190         


Arg Ala Leu Leu Lys His Leu Glu Gly Ile Ser Asp Glu Asp Ile Ile 
        195                 200                 205             


Asn Ile Thr Leu Pro Thr Gly Val Pro Ile Leu Leu Glu Leu Asp Glu 
    210                 215                 220                 


Asn Leu Arg Ala Val Gly Pro His Gln Phe Leu Gly Asp Gln Glu Ala 
225                 230                 235                 240 


Ile Gln Ala Ala Ile Lys Lys Val Glu Asp Gln Gly Lys Val Lys Gln 
                245                 250                 255     


Ala Lys Lys 
            


<210>  1214
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPIFA1__Homo_sapiens__NP_057667

<400>  1214

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210>  1215
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPIFA2__Homo_sapiens__NP_542141

<400>  1215

Met Leu Gln Leu Trp Lys Leu Val Leu Leu Cys Gly Val Leu Thr Gly 
1               5                   10                  15      


Thr Ser Glu Ser Leu Leu Asp Asn Leu Gly Asn Asp Leu Ser Asn Val 
            20                  25                  30          


Val Asp Lys Leu Glu Pro Val Leu His Glu Gly Leu Glu Thr Val Asp 
        35                  40                  45              


Asn Thr Leu Lys Gly Ile Leu Glu Lys Leu Lys Val Asp Leu Gly Val 
    50                  55                  60                  


Leu Gln Lys Ser Ser Ala Trp Gln Leu Ala Lys Gln Lys Ala Gln Glu 
65                  70                  75                  80  


Ala Glu Lys Leu Leu Asn Asn Val Ile Ser Lys Leu Leu Pro Thr Asn 
                85                  90                  95      


Thr Asp Ile Phe Gly Leu Lys Ile Ser Asn Ser Leu Ile Leu Asp Val 
            100                 105                 110         


Lys Ala Glu Pro Ile Asp Asp Gly Lys Gly Leu Asn Leu Ser Phe Pro 
        115                 120                 125             


Val Thr Ala Asn Val Thr Val Ala Gly Pro Ile Ile Gly Gln Ile Ile 
    130                 135                 140                 


Asn Leu Lys Ala Ser Leu Asp Leu Leu Thr Ala Val Thr Ile Glu Thr 
145                 150                 155                 160 


Asp Pro Gln Thr His Gln Pro Val Ala Val Leu Gly Glu Cys Ala Ser 
                165                 170                 175     


Asp Pro Thr Ser Ile Ser Leu Ser Leu Leu Asp Lys His Ser Gln Ile 
            180                 185                 190         


Ile Asn Lys Phe Val Asn Ser Val Ile Asn Thr Leu Lys Ser Thr Val 
        195                 200                 205             


Ser Ser Leu Leu Gln Lys Glu Ile Cys Pro Leu Ile Arg Ile Phe Ile 
    210                 215                 220                 


His Ser Leu Asp Val Asn Val Ile Gln Gln Val Val Asp Asn Pro Gln 
225                 230                 235                 240 


His Lys Thr Gln Leu Gln Thr Leu Ile 
                245                 


<210>  1216
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPIFA3__Homo_sapiens__NP_001035904

<400>  1216

Met Met Cys Pro Leu Trp Arg Leu Leu Ile Phe Leu Gly Leu Leu Ala 
1               5                   10                  15      


Leu Pro Leu Ala Pro His Lys Gln Pro Trp Pro Gly Leu Ala Gln Ala 
            20                  25                  30          


His Arg Asp Asn Lys Ser Thr Leu Ala Arg Ile Ile Ala Gln Gly Leu 
        35                  40                  45              


Ile Lys His Asn Ala Glu Ser Arg Ile Gln Asn Ile His Phe Gly Asp 
    50                  55                  60                  


Arg Leu Asn Ala Ser Ala Gln Val Ala Pro Gly Leu Val Gly Trp Leu 
65                  70                  75                  80  


Ile Ser Gly Arg Lys His Gln Gln Gln Gln Glu Ser Arg Ser Phe Asp 
                85                  90                  95      


Asn Asn Ile Val Lys Met Cys Ala His Met Ser Ile Val Val Glu Phe 
            100                 105                 110         


Trp Leu Glu Lys Asp Glu Phe Gly Arg Arg Asp Leu Val Ile Gly Lys 
        115                 120                 125             


Cys Asp Ala Glu Pro Ser Ser Val His Val Ala Ile Leu Thr Glu Ala 
    130                 135                 140                 


Ile Pro Pro Lys Met Asn Gln Phe Leu Tyr Asn Leu Lys Glu Asn Leu 
145                 150                 155                 160 


Gln Lys Val Leu Pro His Met Val Glu Ser Gln Val Cys Pro Leu Ile 
                165                 170                 175     


Gly Glu Ile Leu Gly Gln Leu Asp Val Lys Leu Leu Lys Ser Leu Ile 
            180                 185                 190         


Glu Gln Glu Ala Ala His Glu Pro Thr His His Glu Thr Ser Gln Pro 
        195                 200                 205             


Ser Ala Cys Gln Ala Gly Glu Ser Pro Ser 
    210                 215             


<210>  1217
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPIFB1__Homo_sapiens__NP_149974

<400>  1217

Met Ala Gly Pro Trp Thr Phe Thr Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ile Gln Ala Thr Leu Ser Pro Thr Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Thr Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Thr Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Thr Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Thr Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys Thr Ile 
        115                 120                 125             


Val Glu Phe His Met Thr Thr Glu Ala Gln Ala Thr Ile Arg Met Asp 
    130                 135                 140                 


Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys Ala Thr 
145                 150                 155                 160 


Ser His Gly Ser Leu Arg Ile Gln Leu Leu His Lys Leu Ser Phe Leu 
                165                 170                 175     


Val Asn Ala Leu Ala Lys Gln Val Met Asn Leu Leu Val Pro Ser Leu 
            180                 185                 190         


Pro Asn Leu Val Lys Asn Gln Leu Cys Pro Val Ile Glu Ala Ser Phe 
        195                 200                 205             


Asn Gly Met Tyr Ala Asp Leu Leu Gln Leu Val Lys Val Pro Ile Ser 
    210                 215                 220                 


Leu Ser Ile Asp Arg Leu Glu Phe Asp Leu Leu Tyr Pro Ala Ile Lys 
225                 230                 235                 240 


Gly Asp Thr Ile Gln Leu Tyr Leu Gly Ala Lys Leu Leu Asp Ser Gln 
                245                 250                 255     


Gly Lys Val Thr Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Thr Met 
            260                 265                 270         


Pro Thr Leu Asp Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val 
        275                 280                 285             


Val Lys Ala Ala Val Ala Ala Val Leu Ser Pro Glu Glu Phe Met Val 
    290                 295                 300                 


Leu Leu Asp Ser Val Leu Pro Glu Ser Ala His Arg Leu Lys Ser Ser 
305                 310                 315                 320 


Ile Gly Leu Ile Asn Glu Lys Ala Ala Asp Lys Leu Gly Ser Thr Gln 
                325                 330                 335     


Ile Val Lys Ile Leu Thr Gln Asp Thr Pro Glu Phe Phe Ile Asp Gln 
            340                 345                 350         


Gly His Ala Lys Val Ala Gln Leu Ile Val Leu Glu Val Phe Pro Ser 
        355                 360                 365             


Ser Glu Ala Leu Arg Pro Leu Phe Thr Leu Gly Ile Glu Ala Ser Ser 
    370                 375                 380                 


Glu Ala Gln Phe Tyr Thr Lys Gly Asp Gln Leu Ile Leu Asn Leu Asn 
385                 390                 395                 400 


Asn Ile Ser Ser Asp Arg Ile Gln Leu Met Asn Ser Gly Ile Gly Trp 
                405                 410                 415     


Phe Gln Pro Asp Val Leu Lys Asn Ile Ile Thr Glu Ile Ile His Ser 
            420                 425                 430         


Ile Leu Leu Pro Asn Gln Asn Gly Lys Leu Arg Ser Gly Val Pro Val 
        435                 440                 445             


Ser Leu Val Lys Ala Leu Gly Phe Glu Ala Ala Glu Ser Ser Leu Thr 
    450                 455                 460                 


Lys Asp Ala Leu Val Leu Thr Pro Ala Ser Leu Trp Lys Pro Ser Ser 
465                 470                 475                 480 


Pro Val Ser Gln 
                


<210>  1218
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPIFB2__Homo_sapiens__NP_079503

<400>  1218

Met Ala Trp Ala Ser Arg Leu Gly Leu Leu Leu Ala Leu Leu Leu Pro 
1               5                   10                  15      


Val Val Gly Ala Ser Thr Pro Gly Thr Val Val Arg Leu Asn Lys Ala 
            20                  25                  30          


Ala Leu Ser Tyr Val Ser Glu Ile Gly Lys Ala Pro Leu Gln Arg Ala 
        35                  40                  45              


Leu Gln Val Thr Val Pro His Phe Leu Asp Trp Ser Gly Glu Ala Leu 
    50                  55                  60                  


Gln Pro Thr Arg Ile Arg Ile Leu Asn Val His Val Pro Arg Leu His 
65                  70                  75                  80  


Leu Lys Phe Ile Ala Gly Phe Gly Val Arg Leu Leu Ala Ala Ala Asn 
                85                  90                  95      


Phe Thr Phe Lys Val Phe Arg Ala Pro Glu Pro Leu Glu Leu Thr Leu 
            100                 105                 110         


Pro Val Glu Leu Leu Ala Asp Thr Arg Val Thr Gln Ser Ser Ile Arg 
        115                 120                 125             


Thr Pro Val Val Ser Ile Ser Ala Cys Ser Leu Phe Ser Gly His Ala 
    130                 135                 140                 


Asn Glu Phe Asp Gly Ser Asn Ser Thr Ser His Ala Leu Leu Val Leu 
145                 150                 155                 160 


Val Gln Lys His Ile Lys Ala Val Leu Ser Asn Lys Leu Cys Leu Ser 
                165                 170                 175     


Ile Ser Asn Leu Val Gln Gly Val Asn Val His Leu Gly Thr Leu Ile 
            180                 185                 190         


Gly Leu Asn Pro Val Gly Pro Glu Ser Gln Ile Arg Tyr Ser Met Val 
        195                 200                 205             


Ser Val Pro Thr Val Thr Ser Asp Tyr Ile Ser Leu Glu Val Asn Ala 
    210                 215                 220                 


Val Leu Phe Leu Leu Gly Lys Pro Ile Ile Leu Pro Thr Asp Ala Thr 
225                 230                 235                 240 


Pro Phe Val Leu Pro Arg His Val Gly Thr Glu Gly Ser Met Ala Thr 
                245                 250                 255     


Val Gly Leu Ser Gln Gln Leu Phe Asp Ser Ala Leu Leu Leu Leu Gln 
            260                 265                 270         


Lys Ala Gly Ala Leu Asn Leu Asp Ile Thr Gly Gln Leu Arg Ser Asp 
        275                 280                 285             


Asp Asn Leu Leu Asn Thr Ser Ala Leu Gly Arg Leu Ile Pro Glu Val 
    290                 295                 300                 


Ala Arg Gln Phe Pro Glu Pro Met Pro Val Val Leu Lys Val Arg Leu 
305                 310                 315                 320 


Gly Ala Thr Pro Val Ala Met Leu His Thr Asn Asn Ala Thr Leu Arg 
                325                 330                 335     


Leu Gln Pro Phe Val Glu Val Leu Ala Thr Ala Ser Asn Ser Ala Phe 
            340                 345                 350         


Gln Ser Leu Phe Ser Leu Asp Val Val Val Asn Leu Arg Leu Gln Leu 
        355                 360                 365             


Ser Val Ser Lys Val Lys Leu Gln Gly Thr Thr Ser Val Leu Gly Asp 
    370                 375                 380                 


Val Gln Leu Thr Val Ala Ser Ser Asn Val Gly Phe Ile Asp Thr Asp 
385                 390                 395                 400 


Gln Val Arg Thr Leu Met Gly Thr Val Phe Glu Lys Pro Leu Leu Asp 
                405                 410                 415     


His Leu Asn Ala Leu Leu Ala Met Gly Ile Ala Leu Pro Gly Val Val 
            420                 425                 430         


Asn Leu His Tyr Val Ala Pro Glu Ile Phe Val Tyr Glu Gly Tyr Val 
        435                 440                 445             


Val Ile Ser Ser Gly Leu Phe Tyr Gln Ser 
    450                 455             


<210>  1219
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPIFC__Homo_sapiens__NP_777592

<400>  1219

Met Cys Thr Lys Thr Ile Pro Val Leu Trp Gly Cys Phe Leu Leu Trp 
1               5                   10                  15      


Asn Leu Tyr Val Ser Ser Ser Gln Thr Ile Tyr Pro Gly Ile Lys Ala 
            20                  25                  30          


Arg Ile Thr Gln Arg Ala Leu Asp Tyr Gly Val Gln Ala Gly Met Lys 
        35                  40                  45              


Met Ile Glu Gln Met Leu Lys Glu Lys Lys Leu Pro Asp Leu Ser Gly 
    50                  55                  60                  


Ser Glu Ser Leu Glu Phe Leu Lys Val Asp Tyr Val Asn Tyr Asn Phe 
65                  70                  75                  80  


Ser Asn Ile Lys Ile Ser Ala Phe Ser Phe Pro Asn Thr Ser Leu Ala 
                85                  90                  95      


Phe Val Pro Gly Val Gly Ile Lys Ala Leu Thr Asn His Gly Thr Ala 
            100                 105                 110         


Asn Ile Ser Thr Asp Trp Gly Phe Glu Ser Pro Leu Phe Gln Asp Thr 
        115                 120                 125             


Gly Gly Ala Asp Leu Phe Leu Ser Gly Val Tyr Phe Thr Gly Ile Ile 
    130                 135                 140                 


Ile Leu Thr Arg Asn Asp Phe Gly His Pro Thr Leu Lys Leu Gln Asp 
145                 150                 155                 160 


Cys Tyr Ala Gln Leu Ser His Ala His Val Ser Phe Ser Gly Glu Leu 
                165                 170                 175     


Ser Val Leu Tyr Asn Ser Phe Ala Glu Pro Met Glu Lys Pro Ile Leu 
            180                 185                 190         


Lys Asn Leu Asn Glu Met Leu Cys Pro Ile Ile Ala Ser Glu Val Lys 
        195                 200                 205             


Ala Leu Asn Ala Asn Leu Ser Thr Leu Glu Val Leu Thr Lys Ile Asp 
    210                 215                 220                 


Asn Tyr Thr Leu Leu Asp Tyr Ser Leu Ile Ser Ser Pro Glu Ile Thr 
225                 230                 235                 240 


Glu Asn Tyr Leu Asp Leu Asn Leu Lys Gly Val Phe Tyr Pro Leu Glu 
                245                 250                 255     


Asn Leu Thr Asp Pro Pro Phe Ser Pro Val Pro Phe Val Leu Pro Glu 
            260                 265                 270         


Arg Ser Asn Ser Met Leu Tyr Ile Gly Ile Ala Glu Tyr Phe Phe Lys 
        275                 280                 285             


Ser Ala Ser Phe Ala His Phe Thr Ala Gly Val Phe Asn Val Thr Leu 
    290                 295                 300                 


Ser Thr Glu Glu Ile Ser Asn His Phe Val Gln Asn Ser Gln Gly Leu 
305                 310                 315                 320 


Gly Asn Val Leu Ser Arg Ile Ala Glu Ile Tyr Ile Leu Ser Gln Pro 
                325                 330                 335     


Phe Met Val Arg Ile Met Ala Thr Glu Pro Pro Ile Ile Asn Leu Gln 
            340                 345                 350         


Pro Gly Asn Phe Thr Leu Asp Ile Pro Ala Ser Ile Met Met Leu Thr 
        355                 360                 365             


Gln Pro Lys Asn Ser Thr Val Glu Thr Ile Val Ser Met Asp Phe Val 
    370                 375                 380                 


Ala Ser Thr Ser Val Gly Leu Val Ile Leu Gly Gln Arg Leu Val Cys 
385                 390                 395                 400 


Ser Leu Ser Leu Asn Arg Phe Arg Leu Ala Leu Pro Glu Ser Asn Arg 
                405                 410                 415     


Ser Asn Ile Glu Val Leu Arg Phe Glu Asn Ile Leu Ser Ser Ile Leu 
            420                 425                 430         


His Phe Gly Val Leu Pro Leu Ala Asn Ala Lys Leu Gln Gln Gly Phe 
        435                 440                 445             


Pro Leu Ser Asn Pro His Lys Phe Leu Phe Val Asn Ser Asp Ile Glu 
    450                 455                 460                 


Val Leu Glu Gly Phe Leu Leu Ile Ser Thr Asp Leu Lys Tyr Glu Thr 
465                 470                 475                 480 


Ser Ser Lys Gln Gln Pro Ser Phe His Val Trp Glu Gly Leu Asn Leu 
                485                 490                 495     


Ile Ser Arg Gln Trp Arg Gly Lys Ser Ala Pro 
            500                 505         


<210>  1220
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPI__Homo_sapiens__NP_001716

<400>  1220

Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Ala 
1               5                   10                  15      


Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val 
            20                  25                  30          


Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala 
        35                  40                  45              


Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys 
    50                  55                  60                  


Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly 
65                  70                  75                  80  


His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser 
                85                  90                  95      


Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser 
            100                 105                 110         


Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe 
        115                 120                 125             


Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile 
    130                 135                 140                 


Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr 
145                 150                 155                 160 


Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His 
                165                 170                 175     


Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys 
            180                 185                 190         


Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys 
        195                 200                 205             


Val Thr Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu 
    210                 215                 220                 


Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu 
225                 230                 235                 240 


Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys 
                245                 250                 255     


Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro 
            260                 265                 270         


Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly 
        275                 280                 285             


Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala 
    290                 295                 300                 


Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser 
305                 310                 315                 320 


Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val 
                325                 330                 335     


Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser 
            340                 345                 350         


Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro 
        355                 360                 365             


Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala 
    370                 375                 380                 


Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser 
385                 390                 395                 400 


Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu 
                405                 410                 415     


Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu 
            420                 425                 430         


Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val 
        435                 440                 445             


Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val 
    450                 455                 460                 


Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe 
465                 470                 475                 480 


Gly Ala Asp Val Val Tyr Lys 
                485         


<210>  1221
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPNT1__Homo_sapiens__NP_001273078

<400>  1221

Met Ser Ile Cys Ser Ser Leu Ala Arg Lys Phe Pro Lys Leu Thr Ile 
1               5                   10                  15      


Ile Gly Glu Glu Asp Leu Pro Ser Glu Glu Val Asp Gln Glu Leu Ile 
            20                  25                  30          


Glu Asp Ser Gln Trp Glu Glu Ile Leu Lys Gln Pro Cys Pro Ser Gln 
        35                  40                  45              


Tyr Ser Ala Ile Lys Glu Glu Asp Leu Val Val Trp Val Asp Pro Leu 
    50                  55                  60                  


Asp Gly Thr Lys Glu Tyr Thr Glu Gly Leu Leu Asp Asn Val Thr Val 
65                  70                  75                  80  


Leu Ile Gly Ile Ala Tyr Glu Gly Lys Ala Ile Ala Gly Val Ile Asn 
                85                  90                  95      


Gln Pro Tyr Tyr Asn Tyr Glu Ala Gly Pro Asp Ala Val Leu Gly Arg 
            100                 105                 110         


Thr Ile Trp Gly Val Leu Gly Leu Gly Ala Phe Gly Phe Gln Leu Lys 
        115                 120                 125             


Glu Val Pro Ala Gly Lys His Ile Ile Thr Thr Thr Arg Ser His Ser 
    130                 135                 140                 


Asn Lys Leu Val Thr Asp Cys Val Ala Ala Met Asn Pro Asp Ala Val 
145                 150                 155                 160 


Leu Arg Val Gly Gly Ala Gly Asn Lys Ile Ile Gln Leu Ile Glu Gly 
                165                 170                 175     


Lys Ala Ser Ala Tyr Val Phe Ala Ser Pro Gly Cys Lys Lys Trp Asp 
            180                 185                 190         


Thr Cys Ala Pro Glu Val Ile Leu His Ala Val Gly Gly Lys Leu Thr 
        195                 200                 205             


Asp Ile His Gly Asn Val Leu Gln Tyr His Lys Asp Val Lys His Met 
    210                 215                 220                 


Asn Ser Ala Gly Val Leu Ala Thr Leu Arg Asn Tyr Asp Tyr Tyr Ala 
225                 230                 235                 240 


Ser Arg Val Pro Glu Ser Ile Lys Asn Ala Leu Val Pro 
                245                 250             


<210>  1222
<211>  2903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPTF__Homo_sapiens__NP_004450

<400>  1222

Met Arg Gly Arg Arg Gly Arg Pro Pro Lys Gln Pro Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Arg Cys Ala Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Thr 
            20                  25                  30          


Ser Gly Pro Ile Gly Gly Leu Arg Ser Arg His Arg Gly Ser Ser Arg 
        35                  40                  45              


Gly Arg Trp Ala Ala Ala Gln Ala Glu Val Ala Pro Lys Thr Arg Leu 
    50                  55                  60                  


Ser Ser Pro Arg Gly Gly Ser Ser Ser Arg Arg Lys Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Ser Thr Ser Ala Pro Gly Arg Gly Gly Arg Gly 
                85                  90                  95      


Gly Gly Gly Gly Arg Thr Gly Gly Gly Gly Gly Gly Gly His Leu Ala 
            100                 105                 110         


Arg Thr Thr Ala Ala Arg Arg Ala Val Asn Lys Val Val Tyr Asp Asp 
        115                 120                 125             


His Glu Ser Glu Glu Glu Glu Glu Glu Glu Asp Met Val Ser Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Asp Gly Asp Ala Glu Glu Thr Gln Asp Ser Glu Asp 
145                 150                 155                 160 


Asp Glu Glu Asp Glu Met Glu Glu Asp Asp Asp Asp Ser Asp Tyr Pro 
                165                 170                 175     


Glu Glu Met Glu Asp Asp Asp Asp Asp Ala Ser Tyr Cys Thr Glu Ser 
            180                 185                 190         


Ser Phe Arg Ser His Ser Thr Tyr Ser Ser Thr Pro Gly Arg Arg Lys 
        195                 200                 205             


Pro Arg Val His Arg Pro Arg Ser Pro Ile Leu Glu Glu Lys Asp Ile 
    210                 215                 220                 


Pro Pro Leu Glu Phe Pro Lys Ser Ser Glu Asp Leu Met Val Pro Asn 
225                 230                 235                 240 


Glu His Ile Met Asn Val Ile Ala Ile Tyr Glu Val Leu Arg Asn Phe 
                245                 250                 255     


Gly Thr Val Leu Arg Leu Ser Pro Phe Arg Phe Glu Asp Phe Cys Ala 
            260                 265                 270         


Ala Leu Val Ser Gln Glu Gln Cys Thr Leu Met Ala Glu Met His Val 
        275                 280                 285             


Val Leu Leu Lys Ala Val Leu Arg Glu Glu Asp Thr Ser Asn Thr Thr 
    290                 295                 300                 


Phe Gly Pro Ala Asp Leu Lys Asp Ser Val Asn Ser Thr Leu Tyr Phe 
305                 310                 315                 320 


Ile Asp Gly Met Thr Trp Pro Glu Val Leu Arg Val Tyr Cys Glu Ser 
                325                 330                 335     


Asp Lys Glu Tyr His His Val Leu Pro Tyr Gln Glu Ala Glu Asp Tyr 
            340                 345                 350         


Pro Tyr Gly Pro Val Glu Asn Lys Ile Lys Val Leu Gln Phe Leu Val 
        355                 360                 365             


Asp Gln Phe Leu Thr Thr Asn Ile Ala Arg Glu Glu Leu Met Ser Glu 
    370                 375                 380                 


Gly Val Ile Gln Tyr Asp Asp His Cys Arg Val Cys His Lys Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Cys Cys Glu Thr Cys Ser Ala Val Tyr His Leu Glu Cys 
                405                 410                 415     


Val Lys Pro Pro Leu Glu Glu Val Pro Glu Asp Glu Trp Gln Cys Glu 
            420                 425                 430         


Val Cys Val Ala His Lys Val Pro Gly Val Thr Asp Cys Val Ala Glu 
        435                 440                 445             


Ile Gln Lys Asn Lys Pro Tyr Ile Arg His Glu Pro Ile Gly Tyr Asp 
    450                 455                 460                 


Arg Ser Arg Arg Lys Tyr Trp Phe Leu Asn Arg Arg Leu Ile Ile Glu 
465                 470                 475                 480 


Glu Asp Thr Glu Asn Glu Asn Glu Lys Lys Ile Trp Tyr Tyr Ser Thr 
                485                 490                 495     


Lys Val Gln Leu Ala Glu Leu Ile Asp Cys Leu Asp Lys Asp Tyr Trp 
            500                 505                 510         


Glu Ala Glu Leu Cys Lys Ile Leu Glu Glu Met Arg Glu Glu Ile His 
        515                 520                 525             


Arg His Met Asp Ile Thr Glu Asp Leu Thr Asn Lys Ala Arg Gly Ser 
    530                 535                 540                 


Asn Lys Ser Phe Leu Ala Ala Ala Asn Glu Glu Ile Leu Glu Ser Ile 
545                 550                 555                 560 


Arg Ala Lys Lys Gly Asp Ile Asp Asn Val Lys Ser Pro Glu Glu Thr 
                565                 570                 575     


Glu Lys Asp Lys Asn Glu Thr Glu Asn Asp Ser Lys Asp Ala Glu Lys 
            580                 585                 590         


Asn Arg Glu Glu Phe Glu Asp Gln Ser Leu Glu Lys Asp Ser Asp Asp 
        595                 600                 605             


Lys Thr Pro Asp Asp Asp Pro Glu Gln Gly Lys Ser Glu Glu Pro Thr 
    610                 615                 620                 


Glu Val Gly Asp Lys Gly Asn Ser Val Ser Ala Asn Leu Gly Asp Asn 
625                 630                 635                 640 


Thr Thr Asn Ala Thr Ser Glu Glu Thr Ser Pro Ser Glu Gly Arg Ser 
                645                 650                 655     


Pro Val Gly Cys Leu Ser Glu Thr Pro Asp Ser Ser Asn Met Ala Glu 
            660                 665                 670         


Lys Lys Val Ala Ser Glu Leu Pro Gln Asp Val Pro Glu Glu Pro Asn 
        675                 680                 685             


Lys Thr Cys Glu Ser Ser Asn Thr Ser Ala Thr Thr Thr Ser Ile Gln 
    690                 695                 700                 


Pro Asn Leu Glu Asn Ser Asn Ser Ser Ser Glu Leu Asn Ser Ser Gln 
705                 710                 715                 720 


Ser Glu Ser Ala Lys Ala Ala Asp Asp Pro Glu Asn Gly Glu Arg Glu 
                725                 730                 735     


Ser His Thr Pro Val Ser Ile Gln Glu Glu Ile Val Gly Asp Phe Lys 
            740                 745                 750         


Ser Glu Lys Ser Asn Gly Glu Leu Ser Glu Ser Pro Gly Ala Gly Lys 
        755                 760                 765             


Gly Ala Ser Gly Ser Thr Arg Ile Ile Thr Arg Leu Arg Asn Pro Asp 
    770                 775                 780                 


Ser Lys Leu Ser Gln Leu Lys Ser Gln Gln Val Ala Ala Ala Ala His 
785                 790                 795                 800 


Glu Ala Asn Lys Leu Phe Lys Glu Gly Lys Glu Val Leu Val Val Asn 
                805                 810                 815     


Ser Gln Gly Glu Ile Ser Arg Leu Ser Thr Lys Lys Glu Val Ile Met 
            820                 825                 830         


Lys Gly Asn Ile Asn Asn Tyr Phe Lys Leu Gly Gln Glu Gly Lys Tyr 
        835                 840                 845             


Arg Val Tyr His Asn Gln Tyr Ser Thr Asn Ser Phe Ala Leu Asn Lys 
    850                 855                 860                 


His Gln His Arg Glu Asp His Asp Lys Arg Arg His Leu Ala His Lys 
865                 870                 875                 880 


Phe Cys Leu Thr Pro Ala Gly Glu Phe Lys Trp Asn Gly Ser Val His 
                885                 890                 895     


Gly Ser Lys Val Leu Thr Ile Ser Thr Leu Arg Leu Thr Ile Thr Gln 
            900                 905                 910         


Leu Glu Asn Asn Ile Pro Ser Ser Phe Leu His Pro Asn Trp Ala Ser 
        915                 920                 925             


His Arg Ala Asn Trp Ile Lys Ala Val Gln Met Cys Ser Lys Pro Arg 
    930                 935                 940                 


Glu Phe Ala Leu Ala Leu Ala Ile Leu Glu Cys Ala Val Lys Pro Val 
945                 950                 955                 960 


Val Met Leu Pro Ile Trp Arg Glu Ser Leu Gly His Thr Arg Leu His 
                965                 970                 975     


Arg Met Thr Ser Ile Glu Arg Glu Glu Lys Glu Lys Val Lys Lys Lys 
            980                 985                 990         


Glu Lys Lys Gln Glu Glu Glu Glu  Thr Met Gln Gln Ala  Thr Trp Val 
        995                 1000                 1005             


Lys Tyr  Thr Phe Pro Val Lys  His Gln Val Trp Lys  Gln Lys Gly 
    1010                 1015                 1020             


Glu Glu  Tyr Arg Val Thr Gly  Tyr Gly Gly Trp Ser  Trp Ile Ser 
    1025                 1030                 1035             


Lys Thr  His Val Tyr Arg Phe  Val Pro Lys Leu Pro  Gly Asn Thr 
    1040                 1045                 1050             


Asn Val  Asn Tyr Arg Lys Ser  Leu Glu Gly Thr Lys  Asn Asn Met 
    1055                 1060                 1065             


Asp Glu  Asn Met Asp Glu Ser  Asp Lys Arg Lys Cys  Ser Arg Ser 
    1070                 1075                 1080             


Pro Lys  Lys Ile Lys Ile Glu  Pro Asp Ser Glu Lys  Asp Glu Val 
    1085                 1090                 1095             


Lys Gly  Ser Asp Ala Ala Lys  Gly Ala Asp Gln Asn  Glu Met Asp 
    1100                 1105                 1110             


Ile Ser  Lys Ile Thr Glu Lys  Lys Asp Gln Asp Val  Lys Glu Leu 
    1115                 1120                 1125             


Leu Asp  Ser Asp Ser Asp Lys  Pro Cys Lys Glu Glu  Pro Met Glu 
    1130                 1135                 1140             


Val Asp  Asp Asp Met Lys Thr  Glu Ser His Val Asn  Cys Gln Glu 
    1145                 1150                 1155             


Ser Ser  Gln Val Asp Val Val  Asn Val Ser Glu Gly  Phe His Leu 
    1160                 1165                 1170             


Arg Thr  Ser Tyr Lys Lys Lys  Thr Lys Ser Ser Lys  Leu Asp Gly 
    1175                 1180                 1185             


Leu Leu  Glu Arg Arg Ile Lys  Gln Phe Thr Leu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Arg Leu  Glu Lys Ile Lys Leu  Glu Gly Gly Ile Lys  Gly Ile Gly 
    1205                 1210                 1215             


Lys Thr  Ser Thr Asn Ser Ser  Lys Asn Leu Ser Glu  Ser Pro Val 
    1220                 1225                 1230             


Ile Thr  Lys Ala Lys Glu Gly  Cys Gln Ser Asp Ser  Met Arg Gln 
    1235                 1240                 1245             


Glu Gln  Ser Pro Asn Ala Asn  Asn Asp Gln Pro Glu  Asp Leu Ile 
    1250                 1255                 1260             


Gln Gly  Cys Ser Glu Ser Asp  Ser Ser Val Leu Arg  Met Ser Asp 
    1265                 1270                 1275             


Pro Ser  His Thr Thr Asn Lys  Leu Tyr Pro Lys Asp  Arg Val Leu 
    1280                 1285                 1290             


Asp Asp  Val Ser Ile Arg Ser  Pro Glu Thr Lys Cys  Pro Lys Gln 
    1295                 1300                 1305             


Asn Ser  Ile Glu Asn Asp Ile  Glu Glu Lys Val Ser  Asp Leu Ala 
    1310                 1315                 1320             


Ser Arg  Gly Gln Glu Pro Ser  Lys Ser Lys Thr Lys  Gly Asn Asp 
    1325                 1330                 1335             


Phe Phe  Ile Asp Asp Ser Lys  Leu Ala Ser Ala Asp  Asp Ile Gly 
    1340                 1345                 1350             


Thr Leu  Ile Cys Lys Asn Lys  Lys Pro Leu Ile Gln  Glu Glu Ser 
    1355                 1360                 1365             


Asp Thr  Ile Val Ser Ser Ser  Lys Ser Ala Leu His  Ser Ser Val 
    1370                 1375                 1380             


Pro Lys  Ser Thr Asn Asp Arg  Asp Ala Thr Pro Leu  Ser Arg Ala 
    1385                 1390                 1395             


Met Asp  Phe Glu Gly Lys Leu  Gly Cys Asp Ser Glu  Ser Asn Ser 
    1400                 1405                 1410             


Thr Leu  Glu Asn Ser Ser Asp  Thr Val Ser Ile Gln  Asp Ser Ser 
    1415                 1420                 1425             


Glu Glu  Asp Met Ile Val Gln  Asn Ser Asn Glu Ser  Ile Ser Glu 
    1430                 1435                 1440             


Gln Phe  Arg Thr Arg Glu Gln  Asp Val Glu Val Leu  Glu Pro Leu 
    1445                 1450                 1455             


Lys Cys  Glu Leu Val Ser Gly  Glu Ser Thr Gly Asn  Cys Glu Asp 
    1460                 1465                 1470             


Arg Leu  Pro Val Lys Gly Thr  Glu Ala Asn Gly Lys  Lys Pro Ser 
    1475                 1480                 1485             


Gln Gln  Lys Lys Leu Glu Glu  Arg Pro Val Asn Lys  Cys Ser Asp 
    1490                 1495                 1500             


Gln Ile  Lys Leu Lys Asn Thr  Thr Asp Lys Lys Asn  Asn Glu Asn 
    1505                 1510                 1515             


Arg Glu  Ser Glu Lys Lys Gly  Gln Arg Thr Ser Thr  Phe Gln Ile 
    1520                 1525                 1530             


Asn Gly  Lys Asp Asn Lys Pro  Lys Ile Tyr Leu Lys  Gly Glu Cys 
    1535                 1540                 1545             


Leu Lys  Glu Ile Ser Glu Ser  Arg Val Val Ser Gly  Asn Val Glu 
    1550                 1555                 1560             


Pro Lys  Val Asn Asn Ile Asn  Lys Ile Ile Pro Glu  Asn Asp Ile 
    1565                 1570                 1575             


Lys Ser  Leu Thr Val Lys Glu  Ser Ala Ile Arg Pro  Phe Ile Asn 
    1580                 1585                 1590             


Gly Asp  Val Ile Met Glu Asp  Phe Asn Glu Arg Asn  Ser Ser Glu 
    1595                 1600                 1605             


Thr Lys  Ser His Leu Leu Ser  Ser Ser Asp Ala Glu  Gly Asn Tyr 
    1610                 1615                 1620             


Arg Asp  Ser Leu Glu Thr Leu  Pro Ser Thr Lys Glu  Ser Asp Ser 
    1625                 1630                 1635             


Thr Gln  Thr Thr Thr Pro Ser  Ala Ser Cys Pro Glu  Ser Asn Ser 
    1640                 1645                 1650             


Val Asn  Gln Val Glu Asp Met  Glu Ile Glu Thr Ser  Glu Val Lys 
    1655                 1660                 1665             


Lys Val  Thr Ser Ser Pro Ile  Thr Ser Glu Glu Glu  Ser Asn Leu 
    1670                 1675                 1680             


Ser Asn  Asp Phe Ile Asp Glu  Asn Gly Leu Pro Ile  Asn Lys Asn 
    1685                 1690                 1695             


Glu Asn  Val Asn Gly Glu Ser  Lys Arg Lys Thr Val  Ile Thr Glu 
    1700                 1705                 1710             


Val Thr  Thr Met Thr Ser Thr  Val Ala Thr Glu Ser  Lys Thr Val 
    1715                 1720                 1725             


Ile Lys  Val Glu Lys Gly Asp  Lys Gln Thr Val Val  Ser Ser Thr 
    1730                 1735                 1740             


Glu Asn  Cys Ala Lys Ser Thr  Val Thr Thr Thr Thr  Thr Thr Val 
    1745                 1750                 1755             


Thr Lys  Leu Ser Thr Pro Ser  Thr Gly Gly Ser Val  Asp Ile Ile 
    1760                 1765                 1770             


Ser Val  Lys Glu Gln Ser Lys  Thr Val Val Thr Thr  Thr Val Thr 
    1775                 1780                 1785             


Asp Ser  Leu Thr Thr Thr Gly  Gly Thr Leu Val Thr  Ser Met Thr 
    1790                 1795                 1800             


Val Ser  Lys Glu Tyr Ser Thr  Arg Asp Lys Val Lys  Leu Met Lys 
    1805                 1810                 1815             


Phe Ser  Arg Pro Lys Lys Thr  Arg Ser Gly Thr Ala  Leu Pro Ser 
    1820                 1825                 1830             


Tyr Arg  Lys Phe Val Thr Lys  Ser Ser Lys Lys Ser  Ile Phe Val 
    1835                 1840                 1845             


Leu Pro  Asn Asp Asp Leu Lys  Lys Leu Ala Arg Lys  Gly Gly Ile 
    1850                 1855                 1860             


Arg Glu  Val Pro Tyr Phe Asn  Tyr Asn Ala Lys Pro  Ala Leu Asp 
    1865                 1870                 1875             


Ile Trp  Pro Tyr Pro Ser Pro  Arg Pro Thr Phe Gly  Ile Thr Trp 
    1880                 1885                 1890             


Arg Tyr  Arg Leu Gln Thr Val  Lys Ser Leu Ala Gly  Val Ser Leu 
    1895                 1900                 1905             


Met Leu  Arg Leu Leu Trp Ala  Ser Leu Arg Trp Asp  Asp Met Ala 
    1910                 1915                 1920             


Ala Lys  Ala Pro Pro Gly Gly  Gly Thr Thr Arg Thr  Glu Thr Ser 
    1925                 1930                 1935             


Glu Thr  Glu Ile Thr Thr Thr  Glu Ile Ile Lys Arg  Arg Asp Val 
    1940                 1945                 1950             


Gly Pro  Tyr Gly Ile Arg Ser  Glu Tyr Cys Ile Arg  Lys Ile Ile 
    1955                 1960                 1965             


Cys Pro  Ile Gly Val Pro Glu  Thr Pro Lys Glu Thr  Pro Thr Pro 
    1970                 1975                 1980             


Gln Arg  Lys Gly Leu Arg Ser  Ser Ala Leu Arg Pro  Lys Arg Pro 
    1985                 1990                 1995             


Glu Thr  Pro Lys Gln Thr Gly  Pro Val Ile Ile Glu  Thr Trp Val 
    2000                 2005                 2010             


Ala Glu  Glu Glu Leu Glu Leu  Trp Glu Ile Arg Ala  Phe Ala Glu 
    2015                 2020                 2025             


Arg Val  Glu Lys Glu Lys Ala  Gln Ala Val Glu Gln  Gln Ala Lys 
    2030                 2035                 2040             


Lys Arg  Leu Glu Gln Gln Lys  Pro Thr Val Ile Ala  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Pro Thr Ser Ser Thr  Thr Ser Thr Ile Ser  Pro Ala Gln 
    2060                 2065                 2070             


Lys Val  Met Val Ala Pro Ile  Ser Gly Ser Val Thr  Thr Gly Thr 
    2075                 2080                 2085             


Lys Met  Val Leu Thr Thr Lys  Val Gly Ser Pro Ala  Thr Val Thr 
    2090                 2095                 2100             


Phe Gln  Gln Asn Lys Asn Phe  His Gln Thr Phe Ala  Thr Trp Val 
    2105                 2110                 2115             


Lys Gln  Gly Gln Ser Asn Ser  Gly Val Val Gln Val  Gln Gln Lys 
    2120                 2125                 2130             


Val Leu  Gly Ile Ile Pro Ser  Ser Thr Gly Thr Ser  Gln Gln Thr 
    2135                 2140                 2145             


Phe Thr  Ser Phe Gln Pro Arg  Thr Ala Thr Val Thr  Ile Arg Pro 
    2150                 2155                 2160             


Asn Thr  Ser Gly Ser Gly Gly  Thr Thr Ser Asn Ser  Gln Val Ile 
    2165                 2170                 2175             


Thr Gly  Pro Gln Ile Arg Pro  Gly Met Thr Val Ile  Arg Thr Pro 
    2180                 2185                 2190             


Leu Gln  Gln Ser Thr Leu Gly  Lys Ala Ile Ile Arg  Thr Pro Val 
    2195                 2200                 2205             


Met Val  Gln Pro Gly Ala Pro  Gln Gln Val Met Thr  Gln Ile Ile 
    2210                 2215                 2220             


Arg Gly  Gln Pro Val Ser Thr  Ala Val Ser Ala Pro  Asn Thr Val 
    2225                 2230                 2235             


Ser Ser  Thr Pro Gly Gln Lys  Ser Leu Thr Ser Ala  Thr Ser Thr 
    2240                 2245                 2250             


Ser Asn  Ile Gln Ser Ser Ala  Ser Gln Pro Pro Arg  Pro Gln Gln 
    2255                 2260                 2265             


Gly Gln  Val Lys Leu Thr Met  Ala Gln Leu Thr Gln  Leu Thr Gln 
    2270                 2275                 2280             


Gly His  Gly Gly Asn Gln Gly  Leu Thr Val Val Ile  Gln Gly Gln 
    2285                 2290                 2295             


Gly Gln  Thr Thr Gly Gln Leu  Gln Leu Ile Pro Gln  Gly Val Thr 
    2300                 2305                 2310             


Val Leu  Pro Gly Pro Gly Gln  Gln Leu Met Gln Ala  Ala Met Pro 
    2315                 2320                 2325             


Asn Gly  Thr Val Gln Arg Phe  Leu Phe Thr Pro Leu  Ala Thr Thr 
    2330                 2335                 2340             


Ala Thr  Thr Ala Ser Thr Thr  Thr Thr Thr Val Ser  Thr Thr Ala 
    2345                 2350                 2355             


Ala Gly  Thr Gly Glu Gln Arg  Gln Ser Lys Leu Ser  Pro Gln Met 
    2360                 2365                 2370             


Gln Val  His Gln Asp Lys Thr  Leu Pro Pro Ala Gln  Ser Ser Ser 
    2375                 2380                 2385             


Val Gly  Pro Ala Glu Ala Gln  Pro Gln Thr Ala Gln  Pro Ser Ala 
    2390                 2395                 2400             


Gln Pro  Gln Pro Gln Thr Gln  Pro Gln Ser Pro Ala  Gln Pro Glu 
    2405                 2410                 2415             


Val Gln  Thr Gln Pro Glu Val  Gln Thr Gln Thr Thr  Val Ser Ser 
    2420                 2425                 2430             


His Val  Pro Ser Glu Ala Gln  Pro Thr His Ala Gln  Ser Ser Lys 
    2435                 2440                 2445             


Pro Gln  Val Ala Ala Gln Ser  Gln Pro Gln Ser Asn  Val Gln Gly 
    2450                 2455                 2460             


Gln Ser  Pro Val Arg Val Gln  Ser Pro Ser Gln Thr  Arg Ile Arg 
    2465                 2470                 2475             


Pro Ser  Thr Pro Ser Gln Leu  Ser Pro Gly Gln Gln  Ser Gln Val 
    2480                 2485                 2490             


Gln Thr  Thr Thr Ser Gln Pro  Ile Pro Ile Gln Pro  His Thr Ser 
    2495                 2500                 2505             


Leu Gln  Ile Pro Ser Gln Gly  Gln Pro Gln Ser Gln  Pro Gln Val 
    2510                 2515                 2520             


Val Met  Lys His Asn Ala Val  Ile Glu His Leu Lys  Gln Lys Lys 
    2525                 2530                 2535             


Ser Met  Thr Pro Ala Glu Arg  Glu Glu Asn Gln Arg  Met Ile Val 
    2540                 2545                 2550             


Cys Asn  Gln Val Met Lys Tyr  Ile Leu Asp Lys Ile  Asp Lys Glu 
    2555                 2560                 2565             


Glu Lys  Gln Ala Ala Lys Lys  Arg Lys Arg Glu Glu  Ser Val Glu 
    2570                 2575                 2580             


Gln Lys  Arg Ser Lys Gln Asn  Ala Thr Lys Leu Ser  Ala Leu Leu 
    2585                 2590                 2595             


Phe Lys  His Lys Glu Gln Leu  Arg Ala Glu Ile Leu  Lys Lys Arg 
    2600                 2605                 2610             


Ala Leu  Leu Asp Lys Asp Leu  Gln Ile Glu Val Gln  Glu Glu Leu 
    2615                 2620                 2625             


Lys Arg  Asp Leu Lys Ile Lys  Lys Glu Lys Asp Leu  Met Gln Leu 
    2630                 2635                 2640             


Ala Gln  Ala Thr Ala Val Ala  Ala Pro Cys Pro Pro  Val Thr Pro 
    2645                 2650                 2655             


Ala Pro  Pro Ala Pro Pro Ala  Pro Pro Pro Ser Pro  Pro Pro Pro 
    2660                 2665                 2670             


Pro Ala  Val Gln His Thr Gly  Leu Leu Ser Thr Pro  Thr Leu Pro 
    2675                 2680                 2685             


Ala Ala  Ser Gln Lys Arg Lys  Arg Glu Glu Glu Lys  Asp Ser Ser 
    2690                 2695                 2700             


Ser Lys  Ser Lys Lys Lys Lys  Met Ile Ser Thr Thr  Ser Lys Glu 
    2705                 2710                 2715             


Thr Lys  Lys Asp Thr Lys Leu  Tyr Cys Ile Cys Lys  Thr Pro Tyr 
    2720                 2725                 2730             


Asp Glu  Ser Lys Phe Tyr Ile  Gly Cys Asp Arg Cys  Gln Asn Trp 
    2735                 2740                 2745             


Tyr His  Gly Arg Cys Val Gly  Ile Leu Gln Ser Glu  Ala Glu Leu 
    2750                 2755                 2760             


Ile Asp  Glu Tyr Val Cys Pro  Gln Cys Gln Ser Thr  Glu Asp Ala 
    2765                 2770                 2775             


Met Thr  Val Leu Thr Pro Leu  Thr Glu Lys Asp Tyr  Glu Gly Leu 
    2780                 2785                 2790             


Lys Arg  Val Leu Arg Ser Leu  Gln Ala His Lys Met  Ala Trp Pro 
    2795                 2800                 2805             


Phe Leu  Glu Pro Val Asp Pro  Asn Asp Ala Pro Asp  Tyr Tyr Gly 
    2810                 2815                 2820             


Val Ile  Lys Glu Pro Met Asp  Leu Ala Thr Met Glu  Glu Arg Val 
    2825                 2830                 2835             


Gln Arg  Arg Tyr Tyr Glu Lys  Leu Thr Glu Phe Val  Ala Asp Met 
    2840                 2845                 2850             


Thr Lys  Ile Phe Asp Asn Cys  Arg Tyr Tyr Asn Pro  Ser Asp Ser 
    2855                 2860                 2865             


Pro Phe  Tyr Gln Cys Ala Glu  Val Leu Glu Ser Phe  Phe Val Gln 
    2870                 2875                 2880             


Lys Leu  Lys Gly Phe Lys Ala  Ser Arg Ser His Asn  Asn Lys Leu 
    2885                 2890                 2895             


Gln Ser  Thr Ala Ser 
    2900             


<210>  1223
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BPY2__Homo_sapiens__NP_004669

<400>  1223

Met Met Thr Leu Val Pro Arg Ala Arg Thr Arg Ala Gly Gln Asp His 
1               5                   10                  15      


Tyr Ser His Pro Cys Pro Arg Phe Ser Gln Val Leu Leu Thr Glu Gly 
            20                  25                  30          


Ile Met Thr Tyr Cys Leu Thr Lys Asn Leu Ser Asp Val Asn Ile Leu 
        35                  40                  45              


His Arg Leu Leu Lys Asn Gly Asn Val Arg Asn Thr Leu Leu Gln Ser 
    50                  55                  60                  


Lys Val Gly Leu Leu Thr Tyr Tyr Val Lys Leu Tyr Pro Gly Glu Val 
65                  70                  75                  80  


Thr Leu Leu Thr Arg Pro Ser Ile Gln Met Arg Leu Cys Cys Ile Thr 
                85                  90                  95      


Gly Ser Val Ser Arg Pro Arg Ser Gln Lys 
            100                 105     


<210>  1224
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRAF__Homo_sapiens__NP_004324

<400>  1224

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210>  1225
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRAP__Homo_sapiens__NP_006759

<400>  1225

Met Ser Val Ser Leu Val Val Ile Arg Leu Glu Leu Ala Glu His Ser 
1               5                   10                  15      


Pro Val Pro Ala Gly Phe Gly Phe Ser Ala Ala Ala Gly Glu Met Ser 
            20                  25                  30          


Asp Glu Glu Ile Lys Lys Thr Thr Leu Ala Ser Ala Val Ala Cys Leu 
        35                  40                  45              


Glu Gly Lys Ser Pro Gly Glu Lys Val Ala Ile Ile His Gln His Leu 
    50                  55                  60                  


Gly Arg Arg Glu Met Thr Asp Val Ile Ile Glu Thr Met Lys Ser Asn 
65                  70                  75                  80  


Pro Asp Glu Leu Lys Thr Thr Val Glu Glu Arg Lys Ser Ser Glu Ala 
                85                  90                  95      


Ser Pro Thr Ala Gln Arg Ser Lys Asp His Ser Lys Glu Cys Ile Asn 
            100                 105                 110         


Ala Ala Pro Asp Ser Pro Ser Lys Gln Leu Pro Asp Gln Ile Ser Phe 
        115                 120                 125             


Phe Ser Gly Asn Pro Ser Val Glu Ile Val His Gly Ile Met His Leu 
    130                 135                 140                 


Tyr Lys Thr Asn Lys Met Thr Ser Leu Lys Glu Asp Val Arg Arg Ser 
145                 150                 155                 160 


Ala Met Leu Cys Ile Leu Thr Val Pro Ala Ala Met Thr Ser His Asp 
                165                 170                 175     


Leu Met Lys Phe Val Ala Pro Phe Asn Glu Val Ile Glu Gln Met Lys 
            180                 185                 190         


Ile Ile Arg Asp Ser Thr Pro Asn Gln Tyr Met Val Leu Ile Lys Phe 
        195                 200                 205             


Arg Ala Gln Ala Asp Ala Asp Ser Phe Tyr Met Thr Cys Asn Gly Arg 
    210                 215                 220                 


Gln Phe Asn Ser Ile Glu Asp Asp Val Cys Gln Leu Val Tyr Val Glu 
225                 230                 235                 240 


Arg Ala Glu Val Leu Lys Ser Glu Asp Gly Ala Ser Leu Pro Val Met 
                245                 250                 255     


Asp Leu Thr Glu Leu Pro Lys Cys Thr Val Cys Leu Glu Arg Met Asp 
            260                 265                 270         


Glu Ser Val Asn Gly Ile Leu Thr Thr Leu Cys Asn His Ser Phe His 
        275                 280                 285             


Ser Gln Cys Leu Gln Arg Trp Asp Asp Thr Thr Cys Pro Val Cys Arg 
    290                 295                 300                 


Tyr Cys Gln Thr Pro Glu Pro Val Glu Glu Asn Lys Cys Phe Glu Cys 
305                 310                 315                 320 


Gly Val Gln Glu Asn Leu Trp Ile Cys Leu Ile Cys Gly His Ile Gly 
                325                 330                 335     


Cys Gly Arg Tyr Val Ser Arg His Ala Tyr Lys His Phe Glu Glu Thr 
            340                 345                 350         


Gln His Thr Tyr Ala Met Gln Leu Thr Asn His Arg Val Trp Asp Tyr 
        355                 360                 365             


Ala Gly Asp Asn Tyr Val His Arg Leu Val Ala Ser Lys Thr Asp Gly 
    370                 375                 380                 


Lys Ile Val Gln Tyr Glu Cys Glu Gly Asp Thr Cys Gln Glu Glu Lys 
385                 390                 395                 400 


Ile Asp Ala Leu Gln Leu Glu Tyr Ser Tyr Leu Leu Thr Ser Gln Leu 
                405                 410                 415     


Glu Ser Gln Arg Ile Tyr Trp Glu Asn Lys Ile Val Arg Ile Glu Lys 
            420                 425                 430         


Asp Thr Ala Glu Glu Ile Asn Asn Met Lys Thr Lys Phe Lys Glu Thr 
        435                 440                 445             


Ile Glu Lys Cys Asp Asn Leu Glu His Lys Leu Asn Asp Leu Leu Lys 
    450                 455                 460                 


Glu Lys Gln Ser Val Glu Arg Lys Cys Thr Gln Leu Asn Thr Lys Val 
465                 470                 475                 480 


Ala Lys Leu Thr Asn Glu Leu Lys Glu Glu Gln Glu Met Asn Lys Cys 
                485                 490                 495     


Leu Arg Ala Asn Gln Val Leu Leu Gln Asn Lys Leu Lys Glu Glu Glu 
            500                 505                 510         


Arg Val Leu Lys Glu Thr Cys Asp Gln Lys Asp Leu Gln Ile Thr Glu 
        515                 520                 525             


Ile Gln Glu Gln Leu Arg Asp Val Met Phe Tyr Leu Glu Thr Gln Gln 
    530                 535                 540                 


Lys Ile Asn His Leu Pro Ala Glu Thr Arg Gln Glu Ile Gln Glu Gly 
545                 550                 555                 560 


Gln Ile Asn Ile Ala Met Ala Ser Ala Ser Ser Pro Ala Ser Ser Gly 
                565                 570                 575     


Gly Ser Gly Lys Leu Pro Ser Arg Lys Gly Arg Ser Lys Arg Gly Lys 
            580                 585                 590         


<210>  1226
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRAT1__Homo_sapiens__NP_689956

<400>  1226

Met Asp Pro Glu Cys Ala Gln Leu Leu Pro Ala Leu Cys Ala Val Leu 
1               5                   10                  15      


Val Asp Pro Arg Gln Pro Val Ala Asp Asp Thr Cys Leu Glu Lys Leu 
            20                  25                  30          


Leu Asp Trp Phe Lys Thr Val Thr Glu Gly Glu Ser Ser Val Val Leu 
        35                  40                  45              


Leu Gln Glu His Pro Cys Leu Val Glu Leu Leu Ser His Val Leu Lys 
    50                  55                  60                  


Val Gln Asp Leu Ser Ser Gly Val Leu Ser Phe Ser Leu Arg Leu Ala 
65                  70                  75                  80  


Gly Thr Phe Ala Ala Gln Glu Asn Cys Phe Gln Tyr Leu Gln Gln Gly 
                85                  90                  95      


Glu Leu Leu Pro Gly Leu Phe Gly Glu Pro Gly Pro Leu Gly Arg Ala 
            100                 105                 110         


Thr Trp Ala Val Pro Thr Val Arg Ser Gly Trp Ile Gln Gly Leu Arg 
        115                 120                 125             


Ser Leu Ala Gln His Pro Ser Ala Leu Arg Phe Leu Ala Asp His Gly 
    130                 135                 140                 


Ala Val Asp Thr Ile Phe Ser Leu Gln Gly Asp Ser Ser Leu Phe Val 
145                 150                 155                 160 


Ala Ser Ala Ala Ser Gln Leu Leu Val His Val Leu Ala Leu Ser Met 
                165                 170                 175     


Arg Gly Gly Ala Glu Gly Gln Pro Cys Leu Pro Gly Gly Asp Trp Pro 
            180                 185                 190         


Ala Cys Ala Gln Lys Ile Met Asp His Val Glu Glu Ser Leu Cys Ser 
        195                 200                 205             


Ala Ala Thr Pro Lys Val Thr Gln Ala Leu Asn Val Leu Thr Thr Thr 
    210                 215                 220                 


Phe Gly Arg Cys Gln Ser Pro Trp Thr Glu Ala Leu Trp Val Arg Leu 
225                 230                 235                 240 


Ser Pro Arg Val Ala Cys Leu Leu Glu Arg Asp Pro Ile Pro Ala Ala 
                245                 250                 255     


His Ser Phe Val Asp Leu Leu Leu Cys Val Ala Arg Ser Pro Val Phe 
            260                 265                 270         


Ser Ser Ser Asp Gly Ser Leu Trp Glu Thr Val Ala Arg Ala Leu Ser 
        275                 280                 285             


Cys Leu Gly Pro Thr His Met Gly Pro Leu Ala Leu Gly Ile Leu Lys 
    290                 295                 300                 


Leu Glu His Cys Pro Gln Ala Leu Arg Thr Gln Ala Phe Gln Val Leu 
305                 310                 315                 320 


Leu Gln Pro Leu Ala Cys Val Leu Lys Ala Thr Val Gln Ala Pro Gly 
                325                 330                 335     


Pro Pro Gly Leu Leu Asp Gly Thr Ala Asp Asp Ala Thr Thr Val Asp 
            340                 345                 350         


Thr Leu Leu Ala Ser Lys Ser Ser Cys Ala Gly Leu Leu Cys Arg Thr 
        355                 360                 365             


Leu Ala His Leu Glu Glu Leu Gln Pro Leu Pro Gln Arg Pro Ser Pro 
    370                 375                 380                 


Trp Pro Gln Ala Ser Leu Leu Gly Ala Thr Val Thr Val Leu Arg Leu 
385                 390                 395                 400 


Cys Asp Gly Ser Ala Ala Pro Ala Ser Ser Val Gly Gly His Leu Cys 
                405                 410                 415     


Gly Thr Leu Ala Gly Cys Val Arg Val Gln Arg Ala Ala Leu Asp Phe 
            420                 425                 430         


Leu Gly Thr Leu Ser Gln Gly Thr Gly Pro Gln Glu Leu Val Thr Gln 
        435                 440                 445             


Ala Leu Ala Val Leu Leu Glu Cys Leu Glu Ser Pro Gly Ser Ser Pro 
    450                 455                 460                 


Thr Val Leu Lys Lys Ala Phe Gln Ala Thr Leu Arg Trp Leu Leu Ser 
465                 470                 475                 480 


Ser Pro Lys Thr Pro Gly Cys Ser Asp Leu Gly Pro Leu Ile Pro Gln 
                485                 490                 495     


Phe Leu Arg Glu Leu Phe Pro Val Leu Gln Lys Arg Leu Cys His Pro 
            500                 505                 510         


Cys Trp Glu Val Arg Asp Ser Ala Leu Glu Phe Leu Thr Gln Leu Ser 
        515                 520                 525             


Arg His Trp Gly Gly Gln Ala Asp Phe Arg Cys Ala Leu Leu Ala Ser 
    530                 535                 540                 


Glu Val Pro Gln Leu Ala Leu Gln Leu Leu Gln Asp Pro Glu Ser Tyr 
545                 550                 555                 560 


Val Arg Ala Ser Ala Val Thr Ala Met Gly Gln Leu Ser Ser Gln Gly 
                565                 570                 575     


Leu His Ala Pro Thr Ser Pro Glu His Ala Glu Ala Arg Gln Ser Leu 
            580                 585                 590         


Phe Leu Glu Leu Leu His Ile Leu Ser Val Asp Ser Glu Gly Phe Pro 
        595                 600                 605             


Arg Arg Ala Val Met Gln Val Phe Thr Glu Trp Leu Arg Asp Gly His 
    610                 615                 620                 


Ala Asp Ala Ala Gln Asp Thr Glu Gln Phe Val Ala Thr Val Leu Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Asp Leu Asp Trp Glu Val Arg Ala Gln Gly Leu Glu 
                645                 650                 655     


Leu Ala Leu Val Phe Leu Gly Gln Thr Leu Gly Pro Pro Arg Thr His 
            660                 665                 670         


Cys Pro Tyr Ala Val Ala Leu Pro Glu Val Ala Pro Ala Gln Pro Leu 
        675                 680                 685             


Thr Glu Ala Leu Arg Ala Leu Cys His Val Gly Leu Phe Asp Phe Ala 
    690                 695                 700                 


Phe Cys Ala Leu Phe Asp Cys Asp Arg Pro Val Ala Gln Lys Ser Cys 
705                 710                 715                 720 


Asp Leu Leu Leu Phe Leu Arg Asp Lys Ile Ala Ser Tyr Ser Ser Leu 
                725                 730                 735     


Arg Glu Ala Arg Gly Ser Pro Asn Thr Ala Ser Ala Glu Ala Thr Leu 
            740                 745                 750         


Pro Arg Trp Arg Ala Gly Glu Gln Ala Gln Pro Pro Gly Asp Gln Glu 
        755                 760                 765             


Pro Glu Ala Val Leu Ala Met Leu Arg Ser Leu Asp Leu Glu Gly Leu 
    770                 775                 780                 


Arg Ser Thr Leu Ala Glu Ser Ser Asp His Val Glu Lys Ser Pro Gln 
785                 790                 795                 800 


Ser Leu Leu Gln Asp Met Leu Ala Thr Gly Gly Phe Leu Gln Gly Asp 
                805                 810                 815     


Glu Ala Asp Cys Tyr 
            820     


<210>  1227
<211>  1863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA1__Homo_sapiens__NP_009225

<400>  1227

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  1228
<211>  3418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA2__Homo_sapiens__NP_000050

<400>  1228

Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp 
    210                 215                 220                 


Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr 
                645                 650                 655     


Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr 
        755                 760                 765             


Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr 
            900                 905                 910         


Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Thr Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Thr  Ser Leu Ala Cys Val  Glu Ile Val Asn Thr  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Thr Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Thr Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Thr Pro  Ser Gln Lys Ala Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu Ser  Thr Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Thr 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Thr Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Thr  Ile Leu Lys Thr Thr  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Thr  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Thr Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Thr  Lys Leu Asn Val Ser  Thr Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Thr Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Thr Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Thr Thr Gly Thr Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Thr  Glu Asn Tyr Lys Arg  Asn Thr Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Thr  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Thr Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Thr Asp  Leu Leu Phe Thr Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Thr Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Thr Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Thr Ser Asn  Lys Glu Gln Leu Thr  Ala Thr Lys 
    1400                 1405                 1410             


Thr Glu  Gln Asn Ile Lys Asp  Phe Glu Thr Ser Asp  Thr Phe Phe 
    1415                 1420                 1425             


Gln Thr  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Thr Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Thr Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Thr  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Thr  Leu Leu Gly Phe His  Thr Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Thr Ser Glu  Ile Thr Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Thr Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Thr Ile Glu Ile  Thr Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Thr Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Thr Glu  Asn Leu Lys Thr Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Thr Ala Lys Ser  Pro Ala Thr 
    1640                 1645                 1650             


Cys Tyr  Thr Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Thr Ser Cys  Ser Arg Lys Thr Ser  Val Ser Gln 
    1670                 1675                 1680             


Thr Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Thr Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Thr Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Thr Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Thr  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Thr 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Thr  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Thr Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Thr Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Thr Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Thr  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Thr Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Thr Cys  Gly Ile Phe Ser Thr  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Thr Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Thr Arg Glu 
    2015                 2020                 2025             


Glu Asn  Thr Ala Ile Arg Thr  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Thr  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Thr 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Thr Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Thr  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Thr Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Thr Glu Thr Phe  Ser Asp Val Pro Val  Lys Thr Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Thr Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Thr  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Thr Asp Ser Lys Leu  Pro Ser His Ala Thr  His Ser Leu 
    2240                 2245                 2250             


Phe Thr  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Thr  Pro Asp Gly 
    2300                 2305                 2310             


Thr Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Thr Cys Val Pro Phe  Arg Thr Thr Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Thr  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Thr Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Thr 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Thr Thr Gly  Arg Pro Thr 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Thr Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Ala Ala Val Thr Phe  Thr Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Thr Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Thr  Ser Thr Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Thr Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Thr Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Thr  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Thr Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Thr Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Thr Ala Ala Lys Thr  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Thr 
    2690                 2695                 2700             


Ser Ser  Asn Lys Thr Ser Ser  Ala Asp Thr Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Thr Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Thr Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Thr Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Thr Arg Pro  Ala Arg Trp Tyr Thr  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Thr Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Thr Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Thr  Thr Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Thr Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Thr Thr Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Thr Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Thr Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Thr  Lys Lys Thr 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Thr  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Thr Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Thr Phe Asn  Lys Met Lys Asn Thr  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Thr Pro Thr  Lys Asp Cys 
    3185                 3190                 3195             


Thr Ser  Gly Pro Tyr Thr Ala  Gln Ile Ile Pro Gly  Thr Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Thr Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Thr Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Thr 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Thr Lys Tyr Glu Thr  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Thr Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Thr Gln  Ala Leu Leu Ser Gly  Ser Thr Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Thr Arg  Thr Ala Pro Thr Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Thr Thr Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Thr Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Thr Ile Thr Thr Lys  Lys Tyr Ile 
    3410                 3415             


<210>  1229
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCC3__Homo_sapiens__NP_001018065

<400>  1229

Met Ala Val Gln Val Val Gln Ala Val Gln Ala Val His Leu Glu Ser 
1               5                   10                  15      


Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu Ser Thr Glu Lys Glu 
            20                  25                  30          


Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn Asp Asp Thr Arg Ser 
        35                  40                  45              


Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met Arg Thr Val Ala Glu 
    50                  55                  60                  


Lys Val Asp Ala Val Arg Ile Val His Ile His Ser Val Ile Ile Leu 
65                  70                  75                  80  


Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu Ile Ser Pro Glu Gln 
                85                  90                  95      


Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu Ala Glu Leu Thr Gly 
            100                 105                 110         


Arg Pro Met Arg Val Val Gly Trp Tyr His Ser His Pro His Ile Thr 
        115                 120                 125             


Val Trp Pro Ser His Val Asp Val Arg Thr Gln Ala Met Tyr Gln Met 
    130                 135                 140                 


Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser Cys Phe Ile Glu Asp 
145                 150                 155                 160 


Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr Cys Phe Gln Ser Ile 
                165                 170                 175     


Gln Ala Gln Lys Ser Ser Glu Tyr Glu Arg Ile Glu Ile Pro Ile His 
            180                 185                 190         


Ile Val Pro His Val Thr Ile Gly Lys Val Cys Leu Glu Ser Ala Val 
        195                 200                 205             


Glu Leu Pro Lys Ile Leu Cys Gln Glu Glu Gln Asp Ala Tyr Arg Arg 
    210                 215                 220                 


Ile His Ser Leu Thr His Leu Asp Ser Val Thr Lys Ile His Asn Gly 
225                 230                 235                 240 


Ser Val Phe Thr Lys Asn Leu Cys Ser Gln Met Ser Ala Val Ser Gly 
                245                 250                 255     


Pro Leu Leu Gln Trp Leu Glu Asp Arg Leu Glu Gln Asn Gln Gln His 
            260                 265                 270         


Leu Gln Glu Leu Gln Gln Glu Lys Glu Glu Leu Met Gln Glu Leu Ser 
        275                 280                 285             


Ser Leu Glu 
    290     


<210>  1230
<211>  1189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRD1__Homo_sapiens__NP_001291737

<400>  1230

Met Arg Arg Lys Gly Arg Cys His Arg Gly Ser Ala Ala Arg His Pro 
1               5                   10                  15      


Ser Ser Pro Cys Ser Val Lys His Ser Pro Thr Arg Glu Thr Leu Thr 
            20                  25                  30          


Tyr Ala Gln Ala Gln Arg Met Val Glu Ile Glu Ile Glu Gly Arg Leu 
        35                  40                  45              


His Arg Ile Ser Ile Phe Asp Pro Leu Glu Ile Ile Leu Glu Asp Asp 
    50                  55                  60                  


Leu Thr Ala Gln Glu Met Ser Glu Cys Asn Ser Asn Lys Glu Asn Ser 
65                  70                  75                  80  


Glu Arg Pro Pro Val Cys Leu Arg Thr Lys Arg His Lys Asn Asn Arg 
                85                  90                  95      


Val Lys Lys Lys Asn Glu Ala Leu Pro Ser Ala His Gly Thr Pro Ala 
            100                 105                 110         


Ser Ala Ser Ala Leu Pro Glu Pro Lys Val Arg Ile Val Glu Tyr Ser 
        115                 120                 125             


Pro Pro Ser Ala Pro Arg Arg Pro Pro Val Tyr Tyr Lys Phe Ile Glu 
    130                 135                 140                 


Lys Ser Ala Glu Glu Leu Asp Asn Glu Val Glu Tyr Asp Met Asp Glu 
145                 150                 155                 160 


Glu Asp Tyr Ala Trp Leu Glu Ile Val Asn Glu Lys Arg Lys Gly Asp 
                165                 170                 175     


Cys Val Pro Ala Val Ser Gln Ser Met Phe Glu Phe Leu Met Asp Arg 
            180                 185                 190         


Phe Glu Lys Glu Ser His Cys Glu Asn Gln Lys Gln Gly Glu Gln Gln 
        195                 200                 205             


Ser Leu Ile Asp Glu Asp Ala Val Cys Cys Ile Cys Met Asp Gly Glu 
    210                 215                 220                 


Cys Gln Asn Ser Asn Val Ile Leu Phe Cys Asp Met Cys Asn Leu Ala 
225                 230                 235                 240 


Val His Gln Glu Cys Tyr Gly Val Pro Tyr Ile Pro Glu Gly Gln Trp 
                245                 250                 255     


Leu Cys Arg His Cys Leu Gln Ser Arg Ala Arg Pro Ala Asp Cys Val 
            260                 265                 270         


Leu Cys Pro Asn Lys Gly Gly Ala Phe Lys Lys Thr Asp Asp Asp Arg 
        275                 280                 285             


Trp Gly His Val Val Cys Ala Leu Trp Ile Pro Glu Val Gly Phe Ala 
    290                 295                 300                 


Asn Thr Val Phe Ile Glu Pro Ile Asp Gly Val Arg Asn Ile Pro Pro 
305                 310                 315                 320 


Ala Arg Trp Lys Leu Thr Cys Tyr Leu Cys Lys Gln Lys Gly Val Gly 
                325                 330                 335     


Ala Cys Ile Gln Cys His Lys Ala Asn Cys Tyr Thr Ala Phe His Val 
            340                 345                 350         


Thr Cys Ala Gln Lys Ala Gly Leu Tyr Met Lys Met Glu Pro Val Lys 
        355                 360                 365             


Glu Leu Thr Gly Gly Gly Thr Thr Phe Ser Val Arg Lys Thr Ala Tyr 
    370                 375                 380                 


Cys Asp Val His Thr Pro Pro Gly Cys Thr Arg Arg Pro Leu Asn Ile 
385                 390                 395                 400 


Tyr Gly Asp Val Glu Met Lys Asn Gly Val Cys Arg Lys Glu Ser Ser 
                405                 410                 415     


Val Lys Thr Val Arg Ser Thr Ser Lys Val Arg Lys Lys Ala Lys Lys 
            420                 425                 430         


Ala Lys Lys Ala Leu Ala Glu Pro Cys Ala Val Leu Pro Thr Val Cys 
        435                 440                 445             


Ala Pro Tyr Ile Pro Pro Gln Arg Leu Asn Arg Ile Ala Asn Gln Val 
    450                 455                 460                 


Ala Ile Gln Arg Lys Lys Gln Phe Val Glu Arg Ala His Ser Tyr Trp 
465                 470                 475                 480 


Leu Leu Lys Arg Leu Ser Arg Asn Gly Ala Pro Leu Leu Arg Arg Leu 
                485                 490                 495     


Gln Ser Ser Leu Gln Ser Gln Arg Ser Ser Gln Gln Arg Glu Asn Asp 
            500                 505                 510         


Glu Glu Met Lys Ala Ala Lys Glu Lys Leu Lys Tyr Trp Gln Arg Leu 
        515                 520                 525             


Arg His Asp Leu Glu Arg Ala Arg Leu Leu Ile Glu Leu Leu Arg Lys 
    530                 535                 540                 


Arg Glu Lys Leu Lys Arg Glu Gln Val Lys Val Glu Gln Val Ala Met 
545                 550                 555                 560 


Glu Leu Arg Leu Thr Pro Leu Thr Val Leu Leu Arg Ser Val Leu Asp 
                565                 570                 575     


Gln Leu Gln Asp Lys Asp Pro Ala Arg Ile Phe Ala Gln Pro Val Ser 
            580                 585                 590         


Leu Lys Glu Val Pro Asp Tyr Leu Asp His Ile Lys His Pro Met Asp 
        595                 600                 605             


Phe Ala Thr Met Arg Lys Arg Leu Glu Ala Gln Gly Tyr Lys Asn Leu 
    610                 615                 620                 


His Glu Phe Glu Glu Asp Phe Asp Leu Ile Ile Asp Asn Cys Met Lys 
625                 630                 635                 640 


Tyr Asn Ala Arg Asp Thr Val Phe Tyr Arg Ala Ala Val Arg Leu Arg 
                645                 650                 655     


Asp Gln Gly Gly Val Val Leu Arg Gln Ala Arg Arg Glu Val Asp Ser 
            660                 665                 670         


Ile Gly Leu Glu Glu Ala Ser Gly Met His Leu Pro Glu Arg Pro Ala 
        675                 680                 685             


Ala Ala Pro Arg Arg Pro Phe Ser Trp Glu Asp Val Asp Arg Leu Leu 
    690                 695                 700                 


Asp Pro Ala Asn Arg Ala His Leu Gly Leu Glu Glu Gln Leu Arg Glu 
705                 710                 715                 720 


Leu Leu Asp Met Leu Asp Leu Thr Cys Ala Met Lys Ser Ser Gly Ser 
                725                 730                 735     


Arg Ser Lys Arg Ala Lys Leu Leu Lys Lys Glu Ile Ala Leu Leu Arg 
            740                 745                 750         


Asn Lys Leu Ser Gln Gln His Ser Gln Pro Leu Pro Thr Gly Pro Gly 
        755                 760                 765             


Leu Glu Gly Phe Glu Glu Asp Gly Ala Ala Leu Gly Pro Glu Ala Gly 
    770                 775                 780                 


Glu Glu Gly Asp Lys Ser Pro Pro Lys Leu Glu Pro Ser Asp Ala Leu 
785                 790                 795                 800 


Pro Leu Pro Ser Asn Ser Glu Thr Asn Ser Glu Pro Pro Thr Leu Lys 
                805                 810                 815     


Pro Val Glu Leu Asn Pro Glu Gln Ser Lys Leu Phe Lys Arg Val Thr 
            820                 825                 830         


Phe Asp Asn Glu Ser His Ser Ala Cys Thr Gln Ser Ala Leu Val Ser 
        835                 840                 845             


Gly Arg Pro Pro Glu Pro Thr Arg Ala Ser Ser Gly Asp Val Pro Ala 
    850                 855                 860                 


Ala Ala Ala Ser Ala Val Ala Glu Pro Ala Ser Asp Val Asn Arg Arg 
865                 870                 875                 880 


Thr Ser Val Leu Phe Cys Lys Ser Lys Ser Val Ser Pro Pro Lys Ser 
                885                 890                 895     


Ala Lys Asn Thr Glu Thr Gln Pro Thr Ser Pro Gln Leu Gly Thr Lys 
            900                 905                 910         


Thr Phe Leu Ser Val Val Leu Pro Arg Leu Glu Thr Leu Leu Gln Pro 
        915                 920                 925             


Arg Lys Arg Ser Arg Ser Thr Cys Gly Asp Ser Glu Val Glu Glu Glu 
    930                 935                 940                 


Ser Pro Gly Lys Arg Leu Asp Ala Gly Leu Thr Asn Gly Phe Gly Gly 
945                 950                 955                 960 


Ala Arg Ser Glu Gln Glu Pro Gly Gly Gly Leu Gly Arg Lys Ala Thr 
                965                 970                 975     


Pro Arg Arg Arg Cys Ala Ser Glu Ser Ser Ile Ser Ser Ser Asn Ser 
            980                 985                 990         


Pro Leu Cys Asp Ser Ser Phe Asn  Ala Pro Lys Cys Gly  Arg Gly Lys 
        995                 1000                 1005             


Pro Ala  Leu Val Arg Arg His  Thr Leu Glu Asp Arg  Ser Glu Leu 
    1010                 1015                 1020             


Ile Ser  Cys Ile Glu Asn Gly  Asn Tyr Ala Lys Ala  Ala Arg Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Gly Gln Ser  Ser Met Trp Ile Ser  Thr Asp Ala 
    1040                 1045                 1050             


Ala Ala  Ser Val Leu Glu Pro  Leu Lys Val Val Trp  Ala Lys Cys 
    1055                 1060                 1065             


Ser Gly  Tyr Pro Ser Tyr Pro  Ala Leu Ile Ile Asp  Pro Lys Met 
    1070                 1075                 1080             


Pro Arg  Val Pro Gly His His  Asn Gly Val Thr Ile  Pro Ala Pro 
    1085                 1090                 1095             


Pro Leu  Asp Val Leu Lys Ile  Gly Glu His Met Gln  Thr Lys Ser 
    1100                 1105                 1110             


Asp Glu  Lys Leu Phe Leu Val  Leu Phe Phe Asp Asn  Lys Arg Ser 
    1115                 1120                 1125             


Trp Gln  Trp Leu Pro Lys Ser  Lys Met Val Pro Leu  Gly Ile Asp 
    1130                 1135                 1140             


Glu Thr  Ile Asp Lys Leu Lys  Met Met Glu Gly Arg  Asn Ser Ser 
    1145                 1150                 1155             


Ile Arg  Lys Ala Val Arg Ile  Ala Phe Asp Arg Ala  Met Asn His 
    1160                 1165                 1170             


Leu Ser  Arg Val His Gly Glu  Pro Thr Ser Asp Leu  Ser Asp Ile 
    1175                 1180                 1185             


Asp 
    


<210>  1231
<211>  801
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRD2__Homo_sapiens__NP_001106653

<400>  1231

Met Leu Gln Asn Val Thr Pro His Asn Lys Leu Pro Gly Glu Gly Asn 
1               5                   10                  15      


Ala Gly Leu Leu Gly Leu Gly Pro Glu Ala Ala Ala Pro Gly Lys Arg 
            20                  25                  30          


Ile Arg Lys Pro Ser Leu Leu Tyr Glu Gly Phe Glu Ser Pro Thr Met 
        35                  40                  45              


Ala Ser Val Pro Ala Leu Gln Leu Thr Pro Ala Asn Pro Pro Pro Pro 
    50                  55                  60                  


Glu Val Ser Asn Pro Lys Lys Pro Gly Arg Val Thr Asn Gln Leu Gln 
65                  70                  75                  80  


Tyr Leu His Lys Val Val Met Lys Ala Leu Trp Lys His Gln Phe Ala 
                85                  90                  95      


Trp Pro Phe Arg Gln Pro Val Asp Ala Val Lys Leu Gly Leu Pro Asp 
            100                 105                 110         


Tyr His Lys Ile Ile Lys Gln Pro Met Asp Met Gly Thr Ile Lys Arg 
        115                 120                 125             


Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp 
    130                 135                 140                 


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp 
145                 150                 155                 160 


Asp Ile Val Leu Met Ala Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys 
                165                 170                 175     


Val Ala Ser Met Pro Gln Glu Glu Gln Glu Leu Val Val Thr Ile Pro 
            180                 185                 190         


Lys Asn Ser His Lys Lys Gly Ala Lys Leu Ala Ala Leu Gln Gly Ser 
        195                 200                 205             


Val Thr Ser Ala His Gln Val Pro Ala Val Ser Ser Val Ser His Thr 
    210                 215                 220                 


Ala Leu Tyr Thr Pro Pro Pro Glu Ile Pro Thr Thr Val Leu Asn Ile 
225                 230                 235                 240 


Pro His Pro Ser Val Ile Ser Ser Pro Leu Leu Lys Ser Leu His Ser 
                245                 250                 255     


Ala Gly Pro Pro Leu Leu Ala Val Thr Ala Ala Pro Pro Ala Gln Pro 
            260                 265                 270         


Leu Ala Lys Lys Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro 
        275                 280                 285             


Thr Pro Thr Ala Ile Leu Ala Pro Gly Ser Pro Ala Ser Pro Pro Gly 
    290                 295                 300                 


Ser Leu Glu Pro Lys Ala Ala Arg Leu Pro Pro Met Arg Arg Glu Ser 
305                 310                 315                 320 


Gly Arg Pro Ile Lys Pro Pro Arg Lys Asp Leu Pro Asp Ser Gln Gln 
                325                 330                 335     


Gln His Gln Ser Ser Lys Lys Gly Lys Leu Ser Glu Gln Leu Lys His 
            340                 345                 350         


Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys His Ala Ala Tyr 
        355                 360                 365             


Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala Leu Gly Leu His 
    370                 375                 380                 


Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu Ser Thr Val Lys 
385                 390                 395                 400 


Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln Glu Phe Ala Ala 
                405                 410                 415     


Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp 
            420                 425                 430         


His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Phe 
        435                 440                 445             


Arg Tyr Ala Lys Met Pro Asp Glu Pro Leu Glu Pro Gly Pro Leu Pro 
    450                 455                 460                 


Val Ser Thr Ala Met Pro Pro Gly Leu Ala Lys Ser Ser Ser Glu Ser 
465                 470                 475                 480 


Ser Ser Glu Glu Ser Ser Ser Glu Ser Ser Ser Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Ser Glu Ser Ser Asp Ser 
            500                 505                 510         


Glu Glu Glu Arg Ala His Arg Leu Ala Glu Leu Gln Glu Gln Leu Arg 
        515                 520                 525             


Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Gly Pro Ile Ser Lys 
    530                 535                 540                 


Pro Lys Arg Lys Arg Glu Lys Lys Glu Lys Lys Lys Lys Arg Lys Ala 
545                 550                 555                 560 


Glu Lys His Arg Gly Arg Ala Gly Ala Asp Glu Asp Asp Lys Gly Pro 
                565                 570                 575     


Arg Ala Pro Arg Pro Pro Gln Pro Lys Lys Ser Lys Lys Ala Ser Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Ala Ala Leu Gly Pro Ser Gly Phe Gly Pro Ser 
        595                 600                 605             


Gly Gly Ser Gly Thr Lys Leu Pro Lys Lys Ala Thr Lys Thr Ala Pro 
    610                 615                 620                 


Pro Ala Leu Pro Thr Gly Tyr Asp Ser Glu Glu Glu Glu Glu Ser Arg 
625                 630                 635                 640 


Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
                645                 650                 655     


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ala Arg 
            660                 665                 670         


Glu Pro Ser Leu Arg Asp Ser Asn Pro Glu Glu Ile Glu Ile Asp Phe 
        675                 680                 685             


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Leu 
    690                 695                 700                 


Ser Cys Leu Arg Lys Lys Pro Arg Lys Pro Tyr Thr Ile Lys Lys Pro 
705                 710                 715                 720 


Val Gly Lys Thr Lys Glu Glu Leu Ala Leu Glu Lys Lys Arg Glu Leu 
                725                 730                 735     


Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Asn Ser Thr Lys Lys 
            740                 745                 750         


Pro Pro Lys Lys Ala Asn Glu Lys Thr Glu Ser Ser Ser Ala Gln Gln 
        755                 760                 765             


Val Ala Val Ser Arg Leu Ser Ala Ser Ser Ser Ser Ser Asp Ser Ser 
    770                 775                 780                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Thr Ser Asp Ser Asp Ser 
785                 790                 795                 800 


Gly 
    


<210>  1232
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRD3__Homo_sapiens__NP_031397

<400>  1232

Met Ser Thr Ala Thr Thr Val Ala Pro Ala Gly Ile Pro Ala Thr Pro 
1               5                   10                  15      


Gly Pro Val Asn Pro Pro Pro Pro Glu Val Ser Asn Pro Ser Lys Pro 
            20                  25                  30          


Gly Arg Lys Thr Asn Gln Leu Gln Tyr Met Gln Asn Val Val Val Lys 
        35                  40                  45              


Thr Leu Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp 
    50                  55                  60                  


Ala Ile Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro 
65                  70                  75                  80  


Met Asp Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp 
                85                  90                  95      


Ser Ala Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys 
            100                 105                 110         


Tyr Ile Tyr Asn Lys Pro Thr Asp Asp Ile Val Leu Met Ala Gln Ala 
        115                 120                 125             


Leu Glu Lys Ile Phe Leu Gln Lys Val Ala Gln Met Pro Gln Glu Glu 
    130                 135                 140                 


Val Glu Leu Leu Pro Pro Ala Pro Lys Gly Lys Gly Arg Lys Pro Ala 
145                 150                 155                 160 


Ala Gly Ala Gln Ser Ala Gly Thr Gln Gln Val Ala Ala Val Ser Ser 
                165                 170                 175     


Val Ser Pro Ala Thr Pro Phe Gln Ser Val Pro Pro Thr Val Ser Gln 
            180                 185                 190         


Thr Pro Val Ile Ala Ala Thr Pro Val Pro Thr Ile Thr Ala Asn Val 
        195                 200                 205             


Thr Ser Val Pro Val Pro Pro Ala Ala Ala Pro Pro Pro Pro Ala Thr 
    210                 215                 220                 


Pro Ile Val Pro Val Val Pro Pro Thr Pro Pro Val Val Lys Lys Lys 
225                 230                 235                 240 


Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ser Ala Ile 
                245                 250                 255     


Thr Ala Ser Arg Ser Glu Ser Pro Pro Pro Leu Ser Asp Pro Lys Gln 
            260                 265                 270         


Ala Lys Val Val Ala Arg Arg Glu Ser Gly Gly Arg Pro Ile Lys Pro 
        275                 280                 285             


Pro Lys Lys Asp Leu Glu Asp Gly Glu Val Pro Gln His Ala Gly Lys 
    290                 295                 300                 


Lys Gly Lys Leu Ser Glu His Leu Arg Tyr Cys Asp Ser Ile Leu Arg 
305                 310                 315                 320 


Glu Met Leu Ser Lys Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys 
                325                 330                 335     


Pro Val Asp Ala Glu Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile 
            340                 345                 350         


Lys His Pro Met Asp Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg 
        355                 360                 365             


Glu Tyr Pro Asp Ala Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe 
    370                 375                 380                 


Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp His Glu Val Val Ala Met 
385                 390                 395                 400 


Ala Arg Lys Leu Gln Asp Val Phe Glu Met Arg Phe Ala Lys Met Pro 
                405                 410                 415     


Asp Glu Pro Val Glu Ala Pro Ala Leu Pro Ala Pro Ala Ala Pro Met 
            420                 425                 430         


Val Ser Lys Gly Ala Glu Ser Ser Arg Ser Ser Glu Glu Ser Ser Ser 
        435                 440                 445             


Asp Ser Gly Ser Ser Asp Ser Glu Glu Glu Arg Ala Thr Arg Leu Ala 
    450                 455                 460                 


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Pro Val Asn Lys Pro Lys Lys Lys Lys Glu Lys Lys Glu 
                485                 490                 495     


Lys Glu Lys Lys Lys Lys Asp Lys Glu Lys Glu Lys Glu Lys His Lys 
            500                 505                 510         


Val Lys Ala Glu Glu Glu Lys Lys Ala Lys Val Ala Pro Pro Ala Lys 
        515                 520                 525             


Gln Ala Gln Gln Lys Lys Ala Pro Ala Lys Lys Ala Asn Ser Thr Thr 
    530                 535                 540                 


Thr Ala Gly Arg Gln Leu Lys Lys Gly Gly Lys Gln Ala Ser Ala Ser 
545                 550                 555                 560 


Tyr Asp Ser Glu Glu Glu Glu Glu Gly Leu Pro Met Ser Tyr Asp Glu 
                565                 570                 575     


Lys Arg Gln Leu Ser Leu Asp Ile Asn Arg Leu Pro Gly Glu Lys Leu 
            580                 585                 590         


Gly Arg Val Val His Ile Ile Gln Ser Arg Glu Pro Ser Leu Arg Asp 
        595                 600                 605             


Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe Glu Thr Leu Lys Pro Thr 
    610                 615                 620                 


Thr Leu Arg Glu Leu Glu Arg Tyr Val Lys Ser Cys Leu Gln Lys Lys 
625                 630                 635                 640 


Gln Arg Lys Pro Phe Ser Ala Ser Gly Lys Lys Gln Ala Ala Lys Ser 
                645                 650                 655     


Lys Glu Glu Leu Ala Gln Glu Lys Lys Lys Glu Leu Glu Lys Arg Leu 
            660                 665                 670         


Gln Asp Val Ser Gly Gln Leu Ser Ser Ser Lys Lys Pro Ala Arg Lys 
        675                 680                 685             


Glu Lys Pro Gly Ser Ala Pro Ser Gly Gly Pro Ser Arg Leu Ser Ser 
    690                 695                 700                 


Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Ser Ser Gly Ser Ser Ser 
705                 710                 715                 720 


Asp Ser Ser Asp Ser Glu 
                725     


<210>  1233
<211>  1362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRD4__Homo_sapiens__XP_011526156

<400>  1233

Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                 200                 205             


Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu 
705                 710                 715                 720 


Met Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys 
                725                 730                 735     


Lys His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro 
            740                 745                 750         


Val Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro 
        755                 760                 765             


Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    770                 775                 780                 


Met Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe 
785                 790                 795                 800 


Ile Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val 
                805                 810                 815     


Phe Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln 
            820                 825                 830         


Pro Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro 
        835                 840                 845             


Pro His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn 
    850                 855                 860                 


Ala Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu 
865                 870                 875                 880 


Pro Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln 
                885                 890                 895     


Thr Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu 
            900                 905                 910         


Leu Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met 
        915                 920                 925             


Gln Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu 
    930                 935                 940                 


Leu Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro 
945                 950                 955                 960 


Pro Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro 
                965                 970                 975     


Pro Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro 
            980                 985                 990         


Pro Pro Arg Pro Val His Leu Gln  Pro Met Gln Phe Ser  Thr His Ile 
        995                 1000                 1005             


Gln Gln  Pro Pro Pro Pro Gln  Gly Gln Gln Pro Pro  His Pro Pro 
    1010                 1015                 1020             


Pro Gly  Gln Gln Pro Pro Pro  Pro Gln Pro Ala Lys  Pro Gln Gln 
    1025                 1030                 1035             


Val Ile  Gln His His His Ser  Pro Arg His His Lys  Ser Asp Pro 
    1040                 1045                 1050             


Tyr Ser  Thr Gly His Leu Arg  Glu Ala Pro Ser Pro  Leu Met Ile 
    1055                 1060                 1065             


His Ser  Pro Gln Met Ser Gln  Phe Gln Ser Leu Thr  His Gln Ser 
    1070                 1075                 1080             


Pro Pro  Gln Gln Asn Val Gln  Pro Lys Lys Gln Glu  Leu Arg Ala 
    1085                 1090                 1095             


Ala Ser  Val Val Gln Pro Gln  Pro Leu Val Val Val  Lys Glu Glu 
    1100                 1105                 1110             


Lys Ile  His Ser Pro Ile Ile  Arg Ser Glu Pro Phe  Ser Pro Ser 
    1115                 1120                 1125             


Leu Arg  Pro Glu Pro Pro Lys  His Pro Glu Ser Ile  Lys Ala Pro 
    1130                 1135                 1140             


Val His  Leu Pro Gln Arg Pro  Glu Met Lys Pro Val  Asp Val Gly 
    1145                 1150                 1155             


Arg Pro  Val Ile Arg Pro Pro  Glu Gln Asn Ala Pro  Pro Pro Gly 
    1160                 1165                 1170             


Ala Pro  Asp Lys Asp Lys Gln  Lys Gln Glu Pro Lys  Thr Pro Val 
    1175                 1180                 1185             


Ala Pro  Lys Lys Asp Leu Lys  Ile Lys Asn Met Gly  Ser Trp Ala 
    1190                 1195                 1200             


Ser Leu  Val Gln Lys His Pro  Thr Thr Pro Ser Ser  Thr Ala Lys 
    1205                 1210                 1215             


Ser Ser  Ser Asp Ser Phe Glu  Gln Phe Arg Arg Ala  Ala Arg Glu 
    1220                 1225                 1230             


Lys Glu  Glu Arg Glu Lys Ala  Leu Lys Ala Gln Ala  Glu His Ala 
    1235                 1240                 1245             


Glu Lys  Glu Lys Glu Arg Leu  Arg Gln Glu Arg Met  Arg Ser Arg 
    1250                 1255                 1260             


Glu Asp  Glu Asp Ala Leu Glu  Gln Ala Arg Arg Ala  His Glu Glu 
    1265                 1270                 1275             


Ala Arg  Arg Arg Gln Glu Gln  Gln Gln Gln Gln Arg  Gln Glu Gln 
    1280                 1285                 1290             


Gln Gln  Gln Gln Gln Gln Gln  Ala Ala Ala Val Ala  Ala Ala Ala 
    1295                 1300                 1305             


Thr Pro  Gln Ala Gln Ser Ser  Gln Pro Gln Ser Met  Leu Asp Gln 
    1310                 1315                 1320             


Gln Arg  Glu Leu Ala Arg Lys  Arg Glu Gln Glu Arg  Arg Arg Arg 
    1325                 1330                 1335             


Glu Ala  Met Ala Ala Thr Ile  Asp Met Asn Phe Gln  Ser Asp Leu 
    1340                 1345                 1350             


Leu Ser  Ile Phe Glu Glu Asn  Leu Phe 
    1355                 1360         


<210>  1234
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRD7__Homo_sapiens__NP_001167455

<400>  1234

Met Gly Lys Lys His Lys Lys His Lys Ser Asp Lys His Leu Tyr Glu 
1               5                   10                  15      


Glu Tyr Val Glu Lys Pro Leu Lys Leu Val Leu Lys Val Gly Gly Asn 
            20                  25                  30          


Glu Val Thr Glu Leu Ser Thr Gly Ser Ser Gly His Asp Ser Ser Leu 
        35                  40                  45              


Phe Glu Asp Lys Asn Asp His Asp Lys His Lys Asp Arg Lys Arg Lys 
    50                  55                  60                  


Lys Arg Lys Lys Gly Glu Lys Gln Ile Pro Gly Glu Glu Lys Gly Arg 
65                  70                  75                  80  


Lys Arg Arg Arg Val Lys Glu Asp Lys Lys Lys Arg Asp Arg Asp Arg 
                85                  90                  95      


Val Glu Asn Glu Ala Glu Lys Asp Leu Gln Cys His Ala Pro Val Arg 
            100                 105                 110         


Leu Asp Leu Pro Pro Glu Lys Pro Leu Thr Ser Ser Leu Ala Lys Gln 
        115                 120                 125             


Glu Glu Val Glu Gln Thr Pro Leu Gln Glu Ala Leu Asn Gln Leu Met 
    130                 135                 140                 


Arg Gln Leu Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val 
145                 150                 155                 160 


Thr Asp Phe Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
                165                 170                 175     


Asp Phe Ser Thr Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser 
            180                 185                 190         


Ile Glu Glu Leu Lys Asp Asn Phe Lys Leu Met Cys Thr Asn Ala Met 
        195                 200                 205             


Ile Tyr Asn Lys Pro Glu Thr Ile Tyr Tyr Lys Ala Ala Lys Lys Leu 
    210                 215                 220                 


Leu His Ser Gly Met Lys Ile Leu Ser Gln Glu Arg Ile Gln Ser Leu 
225                 230                 235                 240 


Lys Gln Ser Ile Asp Phe Met Ala Asp Leu Gln Lys Thr Arg Lys Gln 
                245                 250                 255     


Lys Asp Gly Thr Asp Thr Ser Gln Ser Gly Glu Asp Gly Gly Cys Trp 
            260                 265                 270         


Gln Arg Glu Arg Glu Asp Ser Gly Asp Ala Glu Ala His Ala Phe Lys 
        275                 280                 285             


Ser Pro Ser Lys Glu Asn Lys Lys Lys Asp Lys Asp Met Leu Glu Asp 
    290                 295                 300                 


Lys Phe Lys Ser Asn Asn Leu Glu Arg Glu Gln Glu Gln Leu Asp Arg 
305                 310                 315                 320 


Ile Val Lys Glu Ser Gly Gly Lys Leu Thr Arg Arg Leu Val Asn Ser 
                325                 330                 335     


Gln Cys Glu Phe Glu Arg Arg Lys Pro Asp Gly Thr Thr Thr Leu Gly 
            340                 345                 350         


Leu Leu His Pro Val Asp Pro Ile Val Gly Glu Pro Gly Tyr Cys Pro 
        355                 360                 365             


Val Arg Leu Gly Met Thr Thr Gly Arg Leu Gln Ser Gly Val Asn Thr 
    370                 375                 380                 


Leu Gln Gly Phe Lys Glu Asp Lys Arg Asn Lys Val Thr Pro Val Leu 
385                 390                 395                 400 


Tyr Leu Asn Tyr Gly Pro Tyr Ser Ser Tyr Ala Pro His Tyr Asp Ser 
                405                 410                 415     


Thr Phe Ala Asn Ile Ser Lys Asp Asp Ser Asp Leu Ile Tyr Ser Thr 
            420                 425                 430         


Tyr Gly Glu Asp Ser Asp Leu Pro Ser Asp Phe Ser Ile His Glu Phe 
        435                 440                 445             


Leu Ala Thr Cys Gln Asp Tyr Pro Tyr Val Met Ala Asp Ser Leu Leu 
    450                 455                 460                 


Asp Val Leu Thr Lys Gly Gly His Ser Arg Thr Leu Gln Glu Met Glu 
465                 470                 475                 480 


Met Ser Leu Pro Glu Asp Glu Gly His Thr Arg Thr Leu Asp Thr Ala 
                485                 490                 495     


Lys Glu Met Glu Gln Ile Thr Glu Val Glu Pro Pro Gly Arg Leu Asp 
            500                 505                 510         


Ser Ser Thr Gln Asp Arg Leu Ile Ala Leu Lys Ala Val Thr Asn Phe 
        515                 520                 525             


Gly Val Pro Val Glu Val Phe Asp Ser Glu Glu Ala Glu Ile Phe Gln 
    530                 535                 540                 


Lys Lys Leu Asp Glu Thr Thr Arg Leu Leu Arg Glu Leu Gln Glu Ala 
545                 550                 555                 560 


Gln Asn Glu Arg Leu Ser Thr Arg Pro Pro Pro Asn Met Ile Cys Leu 
                565                 570                 575     


Leu Gly Pro Ser Tyr Arg Glu Met His Leu Ala Glu Gln Val Thr Asn 
            580                 585                 590         


Asn Leu Lys Glu Leu Ala Gln Gln Val Thr Pro Gly Asp Ile Val Ser 
        595                 600                 605             


Thr Tyr Gly Val Arg Lys Ala Met Gly Ile Ser Ile Pro Ser Pro Val 
    610                 615                 620                 


Met Glu Asn Asn Phe Val Asp Leu Thr Glu Asp Thr Glu Glu Pro Lys 
625                 630                 635                 640 


Lys Thr Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
                645                 650         


<210>  1235
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRD8__Homo_sapiens__NP_001157798

<400>  1235

Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met 
        195                 200                 205             


Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu Pro Ser Thr Pro 
    210                 215                 220                 


Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro Pro Gly Ser Ala 
225                 230                 235                 240 


Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp Ser Pro Gln Lys 
                245                 250                 255     


Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser Pro Leu Leu Ser 
            260                 265                 270         


Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser Pro Arg Leu Val 
        275                 280                 285             


Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Thr Gly 
    290                 295                 300                 


Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu 
305                 310                 315                 320 


Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro Ala Ala Ser Val 
                325                 330                 335     


Ser Gln Pro Asp Asn Cys Val Pro Met Glu Ala Val Gly Asp Pro His 
            340                 345                 350         


Thr Val Thr Val Ser Met Asp Ser Ser Glu Ile Ser Met Ile Ile Asn 
        355                 360                 365             


Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly Val Ala Glu Ala Pro Val 
    370                 375                 380                 


Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys Glu Glu Leu Asp Leu Ala 
385                 390                 395                 400 


Glu Lys Met Asp Ile Ala Val Ser Tyr Thr Gly Glu Glu Leu Asp Phe 
                405                 410                 415     


Glu Thr Val Gly Asp Ile Ile Ala Ile Ile Glu Asp Lys Val Asp Asp 
            420                 425                 430         


His Pro Glu Val Leu Asp Val Ala Ala Val Glu Ala Ala Leu Ser Phe 
        435                 440                 445             


Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu Pro Gly Pro Trp Glu His 
    450                 455                 460                 


Pro Ile Gln Gln Glu Arg Asp Lys Pro Val Pro Leu Pro Ala Pro Glu 
465                 470                 475                 480 


Met Thr Val Lys Gln Glu Arg Leu Asp Phe Glu Glu Thr Glu Asn Lys 
                485                 490                 495     


Gly Ile His Glu Leu Val Asp Ile Arg Glu Pro Ser Ala Glu Ile Lys 
            500                 505                 510         


Val Glu Pro Ala Glu Pro Glu Pro Val Ile Ser Gly Ala Glu Ile Val 
        515                 520                 525             


Ala Gly Val Val Pro Ala Thr Ser Met Glu Pro Pro Glu Leu Arg Ser 
    530                 535                 540                 


Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr Ala Ala Gly Glu Ile Val 
545                 550                 555                 560 


Glu Ala Asp Val Ala Ile Gly Lys Gly Asp Glu Thr Pro Leu Thr Asn 
                565                 570                 575     


Val Lys Thr Glu Ala Ser Pro Glu Ser Met Leu Ser Pro Ser His Gly 
            580                 585                 590         


Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala Glu Thr Gln His Lys Phe 
        595                 600                 605             


Glu Met Ser Asp Ser Leu Lys Glu Glu Ser Gly Thr Ile Phe Gly Ser 
    610                 615                 620                 


Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu Glu Glu Asp Gly Val Ser 
625                 630                 635                 640 


Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu Glu Asp Gln Gly Glu Gly 
                645                 650                 655     


Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro Val Ser Glu Ser Asp Asp 
            660                 665                 670         


Gly Phe Ser Ile His Asn Ala Thr Leu Gln Ser His Thr Leu Ala Asp 
        675                 680                 685             


Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln Phe Ser Val Cys Ser Glu 
    690                 695                 700                 


Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile Trp Lys Lys Ala Ile Met 
705                 710                 715                 720 


Leu Val Trp Arg Ala Ala Ala Asn His Arg Tyr Ala Asn Val Phe Leu 
                725                 730                 735     


Gln Pro Val Thr Asp Asp Ile Ala Pro Gly Tyr His Ser Ile Val Gln 
            740                 745                 750         


Arg Pro Met Asp Leu Ser Thr Ile Lys Lys Asn Ile Glu Asn Gly Leu 
        755                 760                 765             


Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp Ile Met Leu Met Phe Gln 
    770                 775                 780                 


Asn Ala Val Met Tyr Asn Ser Ser Asp His Asp Val Tyr His Met Ala 
785                 790                 795                 800 


Val Glu Met Gln Arg Asp Val Leu Glu Gln Ile Gln Gln Phe Leu Ala 
                805                 810                 815     


Thr Gln Leu Ile Met Gln Thr Ser Glu Ser Gly Ile Ser Ala Lys Ser 
            820                 825                 830         


Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln Asp Ala Ser Glu Lys Asp 
        835                 840                 845             


Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu Ala Asp Met Lys Met 
    850                 855                 860                 


Lys Lys 
865     


<210>  1236
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRE__Homo_sapiens__NP_004890

<400>  1236

Met Ser Pro Glu Val Ala Leu Asn Arg Ile Ser Pro Met Leu Ser Pro 
1               5                   10                  15      


Phe Ile Ser Ser Val Val Arg Asn Gly Lys Val Gly Leu Asp Ala Thr 
            20                  25                  30          


Asn Cys Leu Arg Ile Thr Asp Leu Lys Ser Gly Cys Thr Ser Leu Thr 
        35                  40                  45              


Pro Gly Pro Asn Cys Asp Arg Phe Lys Leu His Ile Pro Tyr Ala Gly 
    50                  55                  60                  


Glu Thr Leu Lys Trp Asp Ile Ile Phe Asn Ala Gln Tyr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Asp Phe Ile Phe Gly Glu Asp Ala Glu Phe Leu Pro Asp Pro 
                85                  90                  95      


Ser Ala Leu Gln Asn Leu Ala Ser Trp Asn Pro Ser Asn Pro Glu Cys 
            100                 105                 110         


Leu Leu Leu Val Val Lys Glu Leu Val Gln Gln Tyr His Gln Phe Gln 
        115                 120                 125             


Cys Ser Arg Leu Arg Glu Ser Ser Arg Leu Met Phe Glu Tyr Gln Thr 
    130                 135                 140                 


Leu Leu Glu Glu Pro Gln Tyr Gly Glu Asn Met Glu Ile Tyr Ala Gly 
145                 150                 155                 160 


Lys Lys Asn Asn Trp Thr Gly Glu Phe Ser Ala Arg Phe Leu Leu Lys 
                165                 170                 175     


Leu Pro Val Asp Phe Ser Asn Ile Pro Thr Tyr Leu Leu Lys Asp Val 
            180                 185                 190         


Asn Glu Asp Pro Gly Glu Asp Val Ala Leu Leu Ser Val Ser Phe Glu 
        195                 200                 205             


Asp Thr Glu Ala Thr Gln Val Tyr Pro Lys Leu Tyr Leu Ser Pro Arg 
    210                 215                 220                 


Ile Glu His Ala Leu Gly Gly Ser Ser Ala Leu His Ile Pro Ala Phe 
225                 230                 235                 240 


Pro Gly Gly Gly Cys Leu Ile Asp Tyr Val Pro Gln Val Cys His Leu 
                245                 250                 255     


Leu Thr Asn Lys Val Gln Tyr Val Ile Gln Gly Tyr His Lys Arg Arg 
            260                 265                 270         


Glu Tyr Ile Ala Ala Phe Leu Ser His Phe Gly Thr Gly Val Val Glu 
        275                 280                 285             


Tyr Asp Ala Glu Gly Phe Thr Lys Leu Thr Leu Leu Leu Met Trp Lys 
    290                 295                 300                 


Asp Phe Cys Phe Leu Val His Ile Asp Leu Pro Leu Phe Phe Pro Arg 
305                 310                 315                 320 


Asp Gln Pro Thr Leu Thr Phe Gln Ser Val Tyr His Phe Thr Asn Ser 
                325                 330                 335     


Gly Gln Leu Tyr Ser Gln Ala Gln Lys Asn Tyr Pro Tyr Ser Pro Arg 
            340                 345                 350         


Trp Asp Gly Asn Glu Met Ala Lys Arg Ala Lys Gly Cys Gln Gly Ser 
        355                 360                 365             


Arg Asp Ala Cys Ser Pro Trp Glu Gln Val Leu Ala Phe Ala Val Ala 
    370                 375                 380                 


Lys Thr Gly Cys Lys Leu Leu Gln Pro Gln Arg Asn Trp Pro Ser Ser 
385                 390                 395                 400 


Arg Gly Pro Pro Trp Arg Ala Ser Glu Gly Glu Arg Thr Ala Gln 
                405                 410                 415 


<210>  1237
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRF1__Homo_sapiens__NP_001229715

<400>  1237

Met Ala Val Ser Arg His Leu Thr Arg Gly Arg Lys Met Ala His Val 
1               5                   10                  15      


Ile Ala Ala Cys Leu Tyr Leu Val Cys Arg Thr Glu Gly Thr Pro His 
            20                  25                  30          


Met Leu Leu Asp Leu Ser Asp Leu Leu Gln Val Asn Val Tyr Val Leu 
        35                  40                  45              


Gly Lys Thr Phe Leu Leu Leu Ala Arg Glu Leu Cys Ile Asn Ala Pro 
    50                  55                  60                  


Ala Ile Asp Pro Cys Leu Tyr Ile Pro Arg Phe Ala His Leu Leu Glu 
65                  70                  75                  80  


Phe Gly Glu Lys Asn His Glu Val Ser Met Thr Ala Leu Arg Leu Leu 
                85                  90                  95      


Gln Arg Met Lys Arg Asp Trp Met His Thr Gly Arg Arg Pro Ser Gly 
            100                 105                 110         


Leu Cys Gly Ala Ala Leu Leu Val Ala Ala Arg Met His Asp Phe Arg 
        115                 120                 125             


Arg Thr Val Lys Glu Val Ile Ser Val Val Lys Val Cys Glu Ser Thr 
    130                 135                 140                 


Leu Arg Lys Arg Leu Thr Glu Phe Glu Asp Thr Pro Thr Ser Gln Leu 
145                 150                 155                 160 


Thr Ile Asp Glu Phe Met Lys Ile Asp Leu Glu Glu Glu Cys Asp Pro 
                165                 170                 175     


Pro Ser Tyr Thr Ala Gly Gln Arg Lys Leu Arg Met Lys Gln Leu Glu 
            180                 185                 190         


Gln Val Leu Ser Lys Lys Leu Glu Glu Val Glu Gly Glu Ile Ser Ser 
        195                 200                 205             


Tyr Gln Asp Ala Ile Glu Ile Glu Leu Glu Asn Ser Arg Pro Lys Ala 
    210                 215                 220                 


Lys Gly Gly Leu Ala Ser Leu Ala Lys Asp Gly Ser Thr Glu Asp Thr 
225                 230                 235                 240 


Ala Ser Ser Leu Cys Gly Glu Glu Asp Thr Glu Asp Glu Glu Leu Glu 
                245                 250                 255     


Ala Ala Ala Ser His Leu Asn Lys Asp Leu Tyr Arg Glu Leu Leu Gly 
            260                 265                 270         


Gly Ala Pro Gly Ser Ser Glu Ala Ala Gly Ser Pro Glu Trp Gly Gly 
        275                 280                 285             


Arg Pro Pro Ala Leu Gly Ser Leu Leu Asp Pro Leu Pro Thr Ala Ala 
    290                 295                 300                 


Ser Leu Gly Ile Ser Asp Ser Ile Arg Glu Cys Ile Ser Ser Gln Ser 
305                 310                 315                 320 


Ser Asp Pro Lys Asp Ala Ser Gly Asp Gly Glu Leu Asp Leu Ser Gly 
                325                 330                 335     


Ile Asp Asp Leu Glu Ile Asp Arg Arg Asp Leu Ser Met Pro Arg Cys 
            340                 345                 350         


Ala Lys Ala Lys Ser Gln Pro His Phe Pro Val Leu Ala Gln Tyr Ile 
        355                 360                 365             


Leu Asn Glu Ser Glu Ala Arg Val Lys Ala Glu Leu Trp Met Arg Glu 
    370                 375                 380                 


Asn Ala Glu Tyr Leu Arg Glu Gln Arg Glu Lys Glu Ala Arg Ile Ala 
385                 390                 395                 400 


Lys Glu Lys Glu Leu Gly Ile Tyr Lys Glu His Lys Pro Lys Lys Ser 
                405                 410                 415     


Cys Lys Arg Arg Glu Pro Ile Gln Ala Ser Thr Ala Arg Glu Ala Ile 
            420                 425                 430         


Glu Lys Met Leu Glu Gln Lys Lys Ile Ser Ser Lys Ile Asn Tyr Ser 
        435                 440                 445             


Val Leu Arg Gly Leu Ser Ser Ala Gly Gly Gly Ser Pro His Arg Glu 
    450                 455                 460                 


Asp Ala Gln Pro Glu His Ser Ala Ser Ala Arg Lys Leu Ser Arg Arg 
465                 470                 475                 480 


Arg Thr Pro Ala Ser Arg Ser Gly Ala Asp Pro Val Thr Ser Val Gly 
                485                 490                 495     


Lys Arg Leu Arg Pro Leu Val Ser Thr Gln Pro Ala Lys Lys Val Ala 
            500                 505                 510         


Thr Gly Glu Ala Leu Leu Pro Ser Ser Pro Thr Leu Gly Ala Glu Pro 
        515                 520                 525             


Ala Arg Pro Gln Ala Val Leu Val Glu Ser Gly Pro Val Ser Tyr His 
    530                 535                 540                 


Ala Asp Glu Glu Ala Asp Glu Glu Glu Pro Asp Glu Glu Asp Gly Glu 
545                 550                 555                 560 


Pro Cys Val Ser Ala Leu Gln Met Met Gly Ser Asn Asp Tyr Gly Cys 
                565                 570                 575     


Asp Gly Asp Glu Asp Asp Gly Tyr 
            580                 


<210>  1238
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRF2__Homo_sapiens__NP_060780

<400>  1238

Met Pro Gly Arg Gly Arg Cys Pro Asp Cys Gly Ser Thr Glu Leu Val 
1               5                   10                  15      


Glu Asp Ser His Tyr Ser Gln Ser Gln Leu Val Cys Ser Asp Cys Gly 
            20                  25                  30          


Cys Val Val Thr Glu Gly Val Leu Thr Thr Thr Phe Ser Asp Glu Gly 
        35                  40                  45              


Asn Leu Arg Glu Val Thr Tyr Ser Arg Ser Thr Gly Glu Asn Glu Gln 
    50                  55                  60                  


Val Ser Arg Ser Gln Gln Arg Gly Leu Arg Arg Val Arg Asp Leu Cys 
65                  70                  75                  80  


Arg Val Leu Gln Leu Pro Pro Thr Phe Glu Asp Thr Ala Val Ala Tyr 
                85                  90                  95      


Tyr Gln Gln Ala Tyr Arg His Ser Gly Ile Arg Ala Ala Arg Leu Gln 
            100                 105                 110         


Lys Lys Glu Val Leu Val Gly Cys Cys Val Leu Ile Thr Cys Arg Gln 
        115                 120                 125             


His Asn Trp Pro Leu Thr Met Gly Ala Ile Cys Thr Leu Leu Tyr Ala 
    130                 135                 140                 


Asp Leu Asp Val Phe Ser Ser Thr Tyr Met Gln Ile Val Lys Leu Leu 
145                 150                 155                 160 


Gly Leu Asp Val Pro Ser Leu Cys Leu Ala Glu Leu Val Lys Thr Tyr 
                165                 170                 175     


Cys Ser Ser Phe Lys Leu Phe Gln Ala Ser Pro Ser Val Pro Ala Lys 
            180                 185                 190         


Tyr Val Glu Asp Lys Glu Lys Met Leu Ser Arg Thr Met Gln Leu Val 
        195                 200                 205             


Glu Leu Ala Asn Glu Thr Trp Leu Val Thr Gly Arg His Pro Leu Pro 
    210                 215                 220                 


Val Ile Thr Ala Ala Thr Phe Leu Ala Trp Gln Ser Leu Gln Pro Ala 
225                 230                 235                 240 


Asp Arg Leu Ser Cys Ser Leu Ala Arg Phe Cys Lys Leu Ala Asn Val 
                245                 250                 255     


Asp Leu Pro Tyr Pro Ala Ser Ser Arg Leu Gln Glu Leu Leu Ala Val 
            260                 265                 270         


Leu Leu Arg Met Ala Glu Gln Leu Ala Trp Leu Arg Val Leu Arg Leu 
        275                 280                 285             


Asp Lys Arg Ser Val Val Lys His Ile Gly Asp Leu Leu Gln His Arg 
    290                 295                 300                 


Gln Ser Leu Val Arg Ser Ala Phe Arg Asp Gly Thr Ala Glu Val Glu 
305                 310                 315                 320 


Thr Arg Glu Lys Glu Pro Pro Gly Trp Gly Gln Gly Gln Gly Glu Gly 
                325                 330                 335     


Glu Val Gly Asn Asn Ser Leu Gly Leu Pro Gln Gly Lys Arg Pro Ala 
            340                 345                 350         


Ser Pro Ala Leu Leu Leu Pro Pro Cys Met Leu Lys Ser Pro Lys Arg 
        355                 360                 365             


Ile Cys Pro Val Pro Pro Val Ser Thr Val Thr Gly Asp Glu Asn Ile 
    370                 375                 380                 


Ser Asp Ser Glu Ile Glu Gln Tyr Leu Arg Thr Pro Gln Glu Val Arg 
385                 390                 395                 400 


Asp Phe Gln Arg Ala Gln Ala Ala Arg Gln Ala Ala Thr Ser Val Pro 
                405                 410                 415     


Asn Pro Pro 
            


<210>  1239
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRI3BP__Homo_sapiens__NP_542193

<400>  1239

Met Gly Ala Arg Ala Ser Gly Gly Pro Leu Ala Arg Ala Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Gly Leu Leu Ala Pro Gly Ala 
            20                  25                  30          


Gln Gly Ala Arg Gly Arg Gly Gly Ala Glu Lys Asn Ser Tyr Arg Arg 
        35                  40                  45              


Thr Val Asn Thr Phe Ser Gln Ser Val Ser Ser Leu Phe Gly Glu Asp 
    50                  55                  60                  


Asn Val Arg Ala Ala Gln Lys Phe Leu Ala Arg Leu Thr Glu Arg Phe 
65                  70                  75                  80  


Val Leu Gly Val Asp Met Phe Val Glu Thr Leu Trp Lys Val Trp Thr 
                85                  90                  95      


Glu Leu Leu Asp Val Leu Gly Leu Asp Val Ser Asn Leu Ser Gln Tyr 
            100                 105                 110         


Phe Ser Pro Ala Ser Val Ser Ser Ser Pro Ala Arg Ala Leu Leu Leu 
        115                 120                 125             


Val Gly Val Val Leu Leu Ala Tyr Trp Phe Leu Ser Leu Thr Leu Gly 
    130                 135                 140                 


Phe Thr Phe Ser Val Leu His Val Val Phe Gly Arg Phe Phe Trp Ile 
145                 150                 155                 160 


Val Arg Val Val Leu Phe Ser Met Ser Cys Val Tyr Ile Leu His Lys 
                165                 170                 175     


Tyr Glu Gly Glu Pro Glu Asn Ala Val Leu Pro Leu Cys Phe Val Val 
            180                 185                 190         


Ala Val Tyr Phe Met Thr Gly Pro Met Gly Phe Tyr Trp Arg Ser Ser 
        195                 200                 205             


Pro Ser Gly Pro Ser Asn Pro Ser Asn Pro Ser Val Glu Glu Lys Leu 
    210                 215                 220                 


Glu His Leu Glu Lys Gln Val Arg Leu Leu Asn Ile Arg Leu Asn Arg 
225                 230                 235                 240 


Val Leu Glu Ser Leu Asp Arg Ser Lys Asp Lys 
                245                 250     


<210>  1240
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRI3__Homo_sapiens__NP_001152963

<400>  1240

Met Asp His Lys Pro Leu Leu Gln Glu Arg Pro Pro Ala Tyr Asn Leu 
1               5                   10                  15      


Glu Ala Gly Gln Gly Asp Tyr Ala Cys Gly Pro His Gly Tyr Gly Ala 
            20                  25                  30          


Ile Pro Ala Ala Pro Pro Pro Pro Pro Tyr Pro Tyr Leu Val Thr Gly 
        35                  40                  45              


Ile Pro Thr His His Pro Arg Val Tyr Asn Ile His Ser Arg Thr Val 
    50                  55                  60                  


Thr Arg Tyr Pro Ala Asn Ser Ile Val Val Val Gly Gly Cys Pro Val 
65                  70                  75                  80  


Cys Arg His Gln Arg Ser Ser Trp Leu Tyr Thr Tyr Pro Leu Arg Val 
                85                  90                  95      


Cys Thr 
        


<210>  1241
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRINP1__Homo_sapiens__NP_055433

<400>  1241

Met Asn Trp Arg Phe Val Glu Leu Leu Tyr Phe Leu Phe Ile Trp Gly 
1               5                   10                  15      


Arg Ile Ser Val Gln Pro Ser His Gln Glu Pro Ala Gly Thr Asp Gln 
            20                  25                  30          


His Val Ser Lys Glu Phe Asp Trp Leu Ile Ser Asp Arg Gly Pro Phe 
        35                  40                  45              


His His Ser Arg Ser Tyr Leu Ser Phe Val Glu Arg His Arg Gln Gly 
    50                  55                  60                  


Phe Thr Thr Arg Tyr Lys Ile Tyr Arg Glu Phe Ala Arg Trp Lys Val 
65                  70                  75                  80  


Arg Asn Thr Ala Ile Glu Arg Arg Asp Leu Val Arg His Pro Val Pro 
                85                  90                  95      


Leu Met Pro Glu Phe Gln Arg Ser Ile Arg Leu Leu Gly Arg Arg Pro 
            100                 105                 110         


Thr Thr Gln Gln Phe Ile Asp Thr Ile Ile Lys Lys Tyr Gly Thr His 
        115                 120                 125             


Leu Leu Ile Ser Ala Thr Leu Gly Gly Glu Glu Ala Leu Thr Met Tyr 
    130                 135                 140                 


Met Asp Lys Ser Arg Leu Asp Arg Lys Ser Gly Asn Ala Thr Gln Ser 
145                 150                 155                 160 


Val Glu Ala Leu His Gln Leu Ala Ser Ser Tyr Phe Val Asp Arg Asp 
                165                 170                 175     


Gly Thr Met Arg Arg Leu His Glu Ile Gln Ile Ser Thr Gly Ala Ile 
            180                 185                 190         


Lys Val Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Asn Ser Tyr Asp 
        195                 200                 205             


Asn Leu Asp Ser Val Ser Ser Val Leu Leu Gln Ser Thr Glu Ser Lys 
    210                 215                 220                 


Leu His Leu Gln Gly Leu Gln Ile Ile Phe Pro Gln Tyr Leu Gln Glu 
225                 230                 235                 240 


Lys Phe Val Gln Ser Ala Leu Ser Tyr Ile Met Cys Asn Gly Glu Gly 
                245                 250                 255     


Glu Tyr Leu Cys Gln Asn Ser Gln Cys Arg Cys Gln Cys Ala Glu Glu 
            260                 265                 270         


Phe Pro Gln Cys Asn Cys Pro Ile Thr Asp Ile Gln Ile Met Glu Tyr 
        275                 280                 285             


Thr Leu Ala Asn Met Ala Lys Ser Trp Ala Glu Ala Tyr Lys Asp Leu 
    290                 295                 300                 


Glu Asn Ser Asp Glu Phe Lys Ser Phe Met Lys Arg Leu Pro Ser Asn 
305                 310                 315                 320 


His Phe Leu Thr Ile Gly Ser Ile His Gln His Trp Gly Asn Asp Trp 
                325                 330                 335     


Asp Leu Gln Asn Arg Tyr Lys Leu Leu Gln Ser Ala Thr Glu Ala Gln 
            340                 345                 350         


Arg Gln Lys Ile Gln Arg Thr Ala Arg Lys Leu Phe Gly Leu Ser Val 
        355                 360                 365             


Arg Cys Arg His Asn Pro Asn His Gln Leu Pro Arg Glu Arg Thr Ile 
    370                 375                 380                 


Gln Gln Trp Leu Ala Arg Val Gln Ser Leu Leu Tyr Cys Asn Glu Asn 
385                 390                 395                 400 


Gly Phe Trp Gly Thr Phe Leu Glu Ser Gln Arg Ser Cys Val Cys His 
                405                 410                 415     


Gly Ser Thr Thr Leu Cys Gln Arg Pro Ile Pro Cys Val Ile Gly Gly 
            420                 425                 430         


Asn Asn Ser Cys Ala Met Cys Ser Leu Ala Asn Ile Ser Leu Cys Gly 
        435                 440                 445             


Ser Cys Asn Lys Gly Tyr Lys Leu Tyr Arg Gly Arg Cys Glu Pro Gln 
    450                 455                 460                 


Asn Val Asp Ser Glu Arg Ser Glu Gln Phe Ile Ser Phe Glu Thr Asp 
465                 470                 475                 480 


Leu Asp Phe Gln Asp Leu Glu Leu Lys Tyr Leu Leu Gln Lys Met Asp 
                485                 490                 495     


Ser Arg Leu Tyr Val His Thr Thr Phe Ile Ser Asn Glu Ile Arg Leu 
            500                 505                 510         


Asp Thr Phe Phe Asp Pro Arg Trp Arg Lys Arg Met Ser Leu Thr Leu 
        515                 520                 525             


Lys Ser Asn Lys Asn Arg Met Asp Phe Ile His Met Val Ile Gly Met 
    530                 535                 540                 


Ser Met Arg Ile Cys Gln Met Arg Asn Ser Ser Leu Asp Pro Met Phe 
545                 550                 555                 560 


Phe Val Tyr Val Asn Pro Phe Ser Gly Ser His Ser Glu Gly Trp Asn 
                565                 570                 575     


Met Pro Phe Gly Glu Phe Gly Tyr Pro Arg Trp Glu Lys Ile Arg Leu 
            580                 585                 590         


Gln Asn Ser Gln Cys Tyr Asn Trp Thr Leu Leu Leu Gly Asn Arg Trp 
        595                 600                 605             


Lys Thr Phe Phe Glu Thr Val His Ile Tyr Leu Arg Ser Arg Thr Arg 
    610                 615                 620                 


Leu Pro Thr Leu Leu Arg Asn Glu Thr Gly Gln Gly Pro Val Asp Leu 
625                 630                 635                 640 


Ser Asp Pro Ser Lys Arg Gln Phe Tyr Ile Lys Ile Ser Asp Val Gln 
                645                 650                 655     


Val Phe Gly Tyr Ser Leu Arg Phe Asn Ala Asp Leu Leu Arg Ser Ala 
            660                 665                 670         


Val Gln Gln Val Asn Gln Ser Tyr Thr Gln Gly Gly Gln Phe Tyr Ser 
        675                 680                 685             


Ser Ser Ser Val Met Leu Leu Leu Leu Asp Ile Arg Asp Arg Ile Asn 
    690                 695                 700                 


Arg Leu Ala Pro Pro Val Ala Pro Gly Lys Pro Gln Leu Asp Leu Phe 
705                 710                 715                 720 


Ser Cys Met Leu Lys His Arg Leu Lys Leu Thr Asn Ser Glu Ile Ile 
                725                 730                 735     


Arg Val Asn His Ala Leu Asp Leu Tyr Asn Thr Glu Ile Leu Lys Gln 
            740                 745                 750         


Ser Asp Gln Met Thr Ala Lys Leu Cys 
        755                 760     


<210>  1242
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRINP2__Homo_sapiens__NP_066988

<400>  1242

Met Arg Trp Gln Cys Gly Thr Arg Phe Arg Gly Leu Arg Pro Ala Val 
1               5                   10                  15      


Ala Pro Trp Thr Ala Leu Leu Ala Leu Gly Leu Pro Gly Trp Val Leu 
            20                  25                  30          


Ala Val Ser Ala Thr Ala Ala Ala Val Val Pro Glu Gln His Ala Ser 
        35                  40                  45              


Val Ala Gly Gln His Pro Leu Asp Trp Leu Leu Thr Asp Arg Gly Pro 
    50                  55                  60                  


Phe His Arg Ala Gln Glu Tyr Ala Asp Phe Met Glu Arg Tyr Arg Gln 
65                  70                  75                  80  


Gly Phe Thr Thr Arg Tyr Arg Ile Tyr Arg Glu Phe Ala Arg Trp Lys 
                85                  90                  95      


Val Asn Asn Leu Ala Leu Glu Arg Lys Asp Phe Phe Ser Leu Pro Leu 
            100                 105                 110         


Pro Leu Ala Pro Glu Phe Ile Arg Asn Ile Arg Leu Leu Gly Arg Arg 
        115                 120                 125             


Pro Asn Leu Gln Gln Val Thr Glu Asn Leu Ile Lys Lys Tyr Gly Thr 
    130                 135                 140                 


His Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu Glu Ser Leu Thr Ile 
145                 150                 155                 160 


Phe Val Asp Lys Gln Lys Leu Gly Arg Lys Thr Glu Thr Thr Gly Gly 
                165                 170                 175     


Ala Ser Ile Ile Gly Gly Ser Gly Asn Ser Thr Ala Val Ser Leu Glu 
            180                 185                 190         


Thr Leu His Gln Leu Ala Ala Ser Tyr Phe Ile Asp Arg Glu Ser Thr 
        195                 200                 205             


Leu Arg Arg Leu His His Ile Gln Ile Ala Thr Gly Ala Ile Lys Val 
    210                 215                 220                 


Thr Glu Thr Arg Thr Gly Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu 
225                 230                 235                 240 


Asp Ser Val Ser Ser Val Leu Val Gln Ser Pro Glu Asn Lys Val Gln 
                245                 250                 255     


Leu Leu Gly Leu Gln Val Leu Leu Pro Glu Tyr Leu Arg Glu Arg Phe 
            260                 265                 270         


Val Ala Ala Ala Leu Ser Tyr Ile Thr Cys Ser Ser Glu Gly Glu Leu 
        275                 280                 285             


Val Cys Lys Glu Asn Asp Cys Trp Cys Lys Cys Ser Pro Thr Phe Pro 
    290                 295                 300                 


Glu Cys Asn Cys Pro Asp Ala Asp Ile Gln Ala Met Glu Asp Ser Leu 
305                 310                 315                 320 


Leu Gln Ile Gln Asp Ser Trp Ala Thr His Asn Arg Gln Phe Glu Glu 
                325                 330                 335     


Ser Glu Glu Phe Gln Ala Leu Leu Lys Arg Leu Pro Asp Asp Arg Phe 
            340                 345                 350         


Leu Asn Ser Thr Ala Ile Ser Gln Phe Trp Ala Met Asp Thr Ser Leu 
        355                 360                 365             


Gln His Arg Tyr Gln Gln Leu Gly Ala Gly Leu Lys Val Leu Phe Lys 
    370                 375                 380                 


Lys Thr His Arg Ile Leu Arg Arg Leu Phe Asn Leu Cys Lys Arg Cys 
385                 390                 395                 400 


His Arg Gln Pro Arg Phe Arg Leu Pro Lys Glu Arg Ser Leu Ser Tyr 
                405                 410                 415     


Trp Trp Asn Arg Ile Gln Ser Leu Leu Tyr Cys Gly Glu Ser Thr Phe 
            420                 425                 430         


Pro Gly Thr Phe Leu Glu Gln Ser His Ser Cys Thr Cys Pro Tyr Asp 
        435                 440                 445             


Gln Ser Ser Cys Gln Gly Pro Ile Pro Cys Ala Leu Gly Glu Gly Pro 
    450                 455                 460                 


Ala Cys Ala His Cys Ala Pro Asp Asn Ser Thr Arg Cys Gly Ser Cys 
465                 470                 475                 480 


Asn Pro Gly Tyr Val Leu Ala Gln Gly Leu Cys Arg Pro Glu Val Ala 
                485                 490                 495     


Glu Ser Leu Glu Asn Phe Leu Gly Leu Glu Thr Asp Leu Gln Asp Leu 
            500                 505                 510         


Glu Leu Lys Tyr Leu Leu Gln Lys Gln Asp Ser Arg Ile Glu Val His 
        515                 520                 525             


Ser Ile Phe Ile Ser Asn Asp Met Arg Leu Gly Ser Trp Phe Asp Pro 
    530                 535                 540                 


Ser Trp Arg Lys Arg Met Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys 
545                 550                 555                 560 


Pro Gly Leu Val His Val Met Leu Ala Leu Ser Leu Gln Ile Cys Leu 
                565                 570                 575     


Thr Lys Asn Ser Thr Leu Glu Pro Val Met Ala Ile Tyr Val Asn Pro 
            580                 585                 590         


Phe Gly Gly Ser His Ser Glu Ser Trp Phe Met Pro Val Asn Glu Gly 
        595                 600                 605             


Ser Phe Pro Asp Trp Glu Arg Thr Asn Val Asp Ala Ala Ala Gln Cys 
    610                 615                 620                 


Gln Asn Trp Thr Ile Thr Leu Gly Asn Arg Trp Lys Thr Phe Phe Glu 
625                 630                 635                 640 


Thr Val His Val Tyr Leu Arg Ser Arg Ile Lys Ser Leu Asp Asp Ser 
                645                 650                 655     


Ser Asn Glu Thr Ile Tyr Tyr Glu Pro Leu Glu Met Thr Asp Pro Ser 
            660                 665                 670         


Lys Asn Leu Gly Tyr Met Lys Ile Asn Thr Leu Gln Val Phe Gly Tyr 
        675                 680                 685             


Ser Leu Pro Phe Asp Pro Asp Ala Ile Arg Asp Leu Ile Leu Gln Leu 
    690                 695                 700                 


Asp Tyr Pro Tyr Thr Gln Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu 
705                 710                 715                 720 


Ile Glu Leu Arg Asp Arg Val Asn Gln Leu Ser Pro Pro Gly Lys Val 
                725                 730                 735     


Arg Leu Asp Leu Phe Ser Cys Leu Leu Arg His Arg Leu Lys Leu Ala 
            740                 745                 750         


Asn Asn Glu Val Gly Arg Ile Gln Ser Ser Leu Arg Ala Phe Asn Ser 
        755                 760                 765             


Lys Leu Pro Asn Pro Val Glu Tyr Glu Thr Gly Lys Leu Cys Ser 
    770                 775                 780             


<210>  1243
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRINP3__Homo_sapiens__NP_950252

<400>  1243

Met Ile Trp Arg Ser Arg Ala Gly Ala Glu Leu Phe Ser Leu Met Ala 
1               5                   10                  15      


Leu Trp Glu Trp Ile Ala Leu Ser Leu His Cys Trp Val Leu Ala Val 
            20                  25                  30          


Ala Ala Val Ser Asp Gln His Ala Thr Ser Pro Phe Asp Trp Leu Leu 
        35                  40                  45              


Ser Asp Lys Gly Pro Phe His Arg Ser Gln Glu Tyr Thr Asp Phe Val 
    50                  55                  60                  


Asp Arg Ser Arg Gln Gly Phe Ser Thr Arg Tyr Lys Ile Tyr Arg Glu 
65                  70                  75                  80  


Phe Gly Arg Trp Lys Val Asn Asn Leu Ala Val Glu Arg Arg Asn Phe 
                85                  90                  95      


Leu Gly Ser Pro Leu Pro Leu Ala Pro Glu Phe Phe Arg Asn Ile Arg 
            100                 105                 110         


Leu Leu Gly Arg Arg Pro Thr Leu Gln Gln Ile Thr Glu Asn Leu Ile 
        115                 120                 125             


Lys Lys Tyr Gly Thr His Phe Leu Leu Ser Ala Thr Leu Gly Gly Glu 
    130                 135                 140                 


Glu Ser Leu Thr Ile Phe Val Asp Lys Arg Lys Leu Ser Lys Arg Ala 
145                 150                 155                 160 


Glu Gly Ser Asp Ser Thr Thr Asn Ser Ser Ser Val Thr Leu Glu Thr 
                165                 170                 175     


Leu His Gln Leu Ala Ala Ser Tyr Phe Ile Asp Arg Asp Ser Thr Leu 
            180                 185                 190         


Arg Arg Leu His His Ile Gln Ile Ala Ser Thr Ala Ile Lys Val Thr 
        195                 200                 205             


Glu Thr Arg Thr Gly Pro Leu Gly Cys Ser Asn Tyr Asp Asn Leu Asp 
    210                 215                 220                 


Ser Val Ser Ser Val Leu Val Gln Ser Pro Glu Asn Lys Ile Gln Leu 
225                 230                 235                 240 


Gln Gly Leu Gln Val Leu Leu Pro Asp Tyr Leu Gln Glu Arg Phe Val 
                245                 250                 255     


Gln Ala Ala Leu Ser Tyr Ile Ala Cys Asn Ser Glu Gly Glu Phe Ile 
            260                 265                 270         


Cys Lys Glu Asn Asp Cys Trp Cys His Cys Gly Pro Lys Phe Pro Glu 
        275                 280                 285             


Cys Asn Cys Pro Ser Met Asp Ile Gln Ala Met Glu Glu Asn Leu Leu 
    290                 295                 300                 


Arg Ile Thr Glu Thr Trp Lys Ala Tyr Asn Ser Asp Phe Glu Glu Ser 
305                 310                 315                 320 


Asp Glu Phe Lys Leu Phe Met Lys Arg Leu Pro Met Asn Tyr Phe Leu 
                325                 330                 335     


Asn Thr Ser Thr Ile Met His Leu Trp Thr Met Asp Ser Asn Phe Gln 
            340                 345                 350         


Arg Arg Tyr Glu Gln Leu Glu Asn Ser Met Lys Gln Leu Phe Leu Lys 
        355                 360                 365             


Ala Gln Lys Ile Val His Lys Leu Phe Ser Leu Ser Lys Arg Cys His 
    370                 375                 380                 


Lys Gln Pro Leu Ile Ser Leu Pro Arg Gln Arg Thr Ser Thr Tyr Trp 
385                 390                 395                 400 


Leu Thr Arg Ile Gln Ser Phe Leu Tyr Cys Asn Glu Asn Gly Leu Leu 
                405                 410                 415     


Gly Ser Phe Ser Glu Glu Thr His Ser Cys Thr Cys Pro Asn Asp Gln 
            420                 425                 430         


Val Val Cys Thr Ala Phe Leu Pro Cys Thr Val Gly Asp Ala Ser Ala 
        435                 440                 445             


Cys Leu Thr Cys Ala Pro Asp Asn Arg Thr Arg Cys Gly Thr Cys Asn 
    450                 455                 460                 


Thr Gly Tyr Met Leu Ser Gln Gly Leu Cys Lys Pro Glu Val Ala Glu 
465                 470                 475                 480 


Ser Thr Asp His Tyr Ile Gly Phe Glu Thr Asp Leu Gln Asp Leu Glu 
                485                 490                 495     


Met Lys Tyr Leu Leu Gln Lys Thr Asp Arg Arg Ile Glu Val His Ala 
            500                 505                 510         


Ile Phe Ile Ser Asn Asp Met Arg Leu Asn Ser Trp Phe Asp Pro Ser 
        515                 520                 525             


Trp Arg Lys Arg Met Leu Leu Thr Leu Lys Ser Asn Lys Tyr Lys Ser 
    530                 535                 540                 


Ser Leu Val His Met Ile Leu Gly Leu Ser Leu Gln Ile Cys Leu Thr 
545                 550                 555                 560 


Lys Asn Ser Thr Leu Glu Pro Val Leu Ala Val Tyr Val Asn Pro Phe 
                565                 570                 575     


Gly Gly Ser His Ser Glu Ser Trp Phe Met Pro Val Asn Glu Asn Ser 
            580                 585                 590         


Phe Pro Asp Trp Glu Arg Thr Lys Leu Asp Leu Pro Leu Gln Cys Tyr 
        595                 600                 605             


Asn Trp Thr Leu Thr Leu Gly Asn Lys Trp Lys Thr Phe Phe Glu Thr 
    610                 615                 620                 


Val His Ile Tyr Leu Arg Ser Arg Ile Lys Ser Asn Gly Pro Asn Gly 
625                 630                 635                 640 


Asn Glu Ser Ile Tyr Tyr Glu Pro Leu Glu Phe Ile Asp Pro Ser Arg 
                645                 650                 655     


Asn Leu Gly Tyr Met Lys Ile Asn Asn Ile Gln Val Phe Gly Tyr Ser 
            660                 665                 670         


Met His Phe Asp Pro Glu Ala Ile Arg Asp Leu Ile Leu Gln Leu Asp 
        675                 680                 685             


Tyr Pro Tyr Thr Gln Gly Ser Gln Asp Ser Ala Leu Leu Gln Leu Leu 
    690                 695                 700                 


Glu Ile Arg Asp Arg Val Asn Lys Leu Ser Pro Pro Gly Gln Arg Arg 
705                 710                 715                 720 


Leu Asp Leu Phe Ser Cys Leu Leu Arg His Arg Leu Lys Leu Ser Thr 
                725                 730                 735     


Ser Glu Val Val Arg Ile Gln Ser Ala Leu Gln Ala Phe Asn Ala Lys 
            740                 745                 750         


Leu Pro Asn Thr Met Asp Tyr Asp Thr Thr Lys Leu Cys Ser 
        755                 760                 765     


<210>  1244
<211>  1249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRIP1__Homo_sapiens__NP_114432

<400>  1244

Met Ser Ser Met Trp Ser Glu Tyr Thr Ile Gly Gly Val Lys Ile Tyr 
1               5                   10                  15      


Phe Pro Tyr Lys Ala Tyr Pro Ser Gln Leu Ala Met Met Asn Ser Ile 
            20                  25                  30          


Leu Arg Gly Leu Asn Ser Lys Gln His Cys Leu Leu Glu Ser Pro Thr 
        35                  40                  45              


Gly Ser Gly Lys Ser Leu Ala Leu Leu Cys Ser Ala Leu Ala Trp Gln 
    50                  55                  60                  


Gln Ser Leu Ser Gly Lys Pro Ala Asp Glu Gly Val Ser Glu Lys Ala 
65                  70                  75                  80  


Glu Val Gln Leu Ser Cys Cys Cys Ala Cys His Ser Lys Asp Phe Thr 
                85                  90                  95      


Asn Asn Asp Met Asn Gln Gly Thr Ser Arg His Phe Asn Tyr Pro Ser 
            100                 105                 110         


Thr Pro Pro Ser Glu Arg Asn Gly Thr Ser Ser Thr Cys Gln Asp Ser 
        115                 120                 125             


Pro Glu Lys Thr Thr Leu Ala Ala Lys Leu Ser Ala Lys Lys Gln Ala 
    130                 135                 140                 


Ser Ile Tyr Arg Asp Glu Asn Asp Asp Phe Gln Val Glu Lys Lys Arg 
145                 150                 155                 160 


Ile Arg Pro Leu Glu Thr Thr Gln Gln Ile Arg Lys Arg His Cys Phe 
                165                 170                 175     


Gly Thr Glu Val His Asn Leu Asp Ala Lys Val Asp Ser Gly Lys Thr 
            180                 185                 190         


Val Lys Leu Asn Ser Pro Leu Glu Lys Ile Asn Ser Phe Ser Pro Gln 
        195                 200                 205             


Lys Pro Pro Gly His Cys Ser Arg Cys Cys Cys Ser Thr Lys Gln Gly 
    210                 215                 220                 


Asn Ser Gln Glu Ser Ser Asn Thr Ile Lys Lys Asp His Thr Gly Lys 
225                 230                 235                 240 


Ser Lys Ile Pro Lys Ile Tyr Phe Gly Thr Arg Thr His Lys Gln Ile 
                245                 250                 255     


Ala Gln Ile Thr Arg Glu Leu Arg Arg Thr Ala Tyr Ser Gly Val Pro 
            260                 265                 270         


Met Thr Ile Leu Ser Ser Arg Asp His Thr Cys Val His Pro Glu Val 
        275                 280                 285             


Val Gly Asn Phe Asn Arg Asn Glu Lys Cys Met Glu Leu Leu Asp Gly 
    290                 295                 300                 


Lys Asn Gly Lys Ser Cys Tyr Phe Tyr His Gly Val His Lys Ile Ser 
305                 310                 315                 320 


Asp Gln His Thr Leu Gln Thr Phe Gln Gly Met Cys Lys Ala Trp Asp 
                325                 330                 335     


Ile Glu Glu Leu Val Ser Leu Gly Lys Lys Leu Lys Ala Cys Pro Tyr 
            340                 345                 350         


Tyr Thr Ala Arg Glu Leu Ile Gln Asp Ala Asp Ile Ile Phe Cys Pro 
        355                 360                 365             


Tyr Asn Tyr Leu Leu Asp Ala Gln Ile Arg Glu Ser Met Asp Leu Asn 
    370                 375                 380                 


Leu Lys Glu Gln Val Val Ile Leu Asp Glu Ala His Asn Ile Glu Asp 
385                 390                 395                 400 


Cys Ala Arg Glu Ser Ala Ser Tyr Ser Val Thr Glu Val Gln Leu Arg 
                405                 410                 415     


Phe Ala Arg Asp Glu Leu Asp Ser Met Val Asn Asn Asn Ile Arg Lys 
            420                 425                 430         


Lys Asp His Glu Pro Leu Arg Ala Val Cys Cys Ser Leu Ile Asn Trp 
        435                 440                 445             


Leu Glu Ala Asn Ala Glu Tyr Leu Val Glu Arg Asp Tyr Glu Ser Ala 
    450                 455                 460                 


Cys Lys Ile Trp Ser Gly Asn Glu Met Leu Leu Thr Leu His Lys Met 
465                 470                 475                 480 


Gly Ile Thr Thr Ala Thr Phe Pro Ile Leu Gln Gly His Phe Ser Ala 
                485                 490                 495     


Val Leu Gln Lys Glu Glu Lys Ile Ser Pro Ile Tyr Gly Lys Glu Glu 
            500                 505                 510         


Ala Arg Glu Val Pro Val Ile Ser Ala Ser Thr Gln Ile Met Leu Lys 
        515                 520                 525             


Gly Leu Phe Met Val Leu Asp Tyr Leu Phe Arg Gln Asn Ser Arg Phe 
    530                 535                 540                 


Ala Asp Asp Tyr Lys Ile Ala Ile Gln Gln Thr Tyr Ser Trp Thr Asn 
545                 550                 555                 560 


Gln Ile Asp Ile Ser Asp Lys Asn Gly Leu Leu Val Leu Pro Lys Asn 
                565                 570                 575     


Lys Lys Arg Ser Arg Gln Lys Thr Ala Val His Val Leu Asn Phe Trp 
            580                 585                 590         


Cys Leu Asn Pro Ala Val Ala Phe Ser Asp Ile Asn Gly Lys Val Gln 
        595                 600                 605             


Thr Ile Val Leu Thr Ser Gly Thr Leu Ser Pro Met Lys Ser Phe Ser 
    610                 615                 620                 


Ser Glu Leu Gly Val Thr Phe Thr Ile Gln Leu Glu Ala Asn His Ile 
625                 630                 635                 640 


Ile Lys Asn Ser Gln Val Trp Val Gly Thr Ile Gly Ser Gly Pro Lys 
                645                 650                 655     


Gly Arg Asn Leu Cys Ala Thr Phe Gln Asn Thr Glu Thr Phe Glu Phe 
            660                 665                 670         


Gln Asp Glu Val Gly Ala Leu Leu Leu Ser Val Cys Gln Thr Val Ser 
        675                 680                 685             


Gln Gly Ile Leu Cys Phe Leu Pro Ser Tyr Lys Leu Leu Glu Lys Leu 
    690                 695                 700                 


Lys Glu Arg Trp Leu Ser Thr Gly Leu Trp His Asn Leu Glu Leu Val 
705                 710                 715                 720 


Lys Thr Val Ile Val Glu Pro Gln Gly Gly Glu Lys Thr Asn Phe Asp 
                725                 730                 735     


Glu Leu Leu Gln Val Tyr Tyr Asp Ala Ile Lys Tyr Lys Gly Glu Lys 
            740                 745                 750         


Asp Gly Ala Leu Leu Val Ala Val Cys Arg Gly Lys Val Ser Glu Gly 
        755                 760                 765             


Leu Asp Phe Ser Asp Asp Asn Ala Arg Ala Val Ile Thr Ile Gly Ile 
    770                 775                 780                 


Pro Phe Pro Asn Val Lys Asp Leu Gln Val Glu Leu Lys Arg Gln Tyr 
785                 790                 795                 800 


Asn Asp His His Ser Lys Leu Arg Gly Leu Leu Pro Gly Arg Gln Trp 
                805                 810                 815     


Tyr Glu Ile Gln Ala Tyr Arg Ala Leu Asn Gln Ala Leu Gly Arg Cys 
            820                 825                 830         


Ile Arg His Arg Asn Asp Trp Gly Ala Leu Ile Leu Val Asp Asp Arg 
        835                 840                 845             


Phe Arg Asn Asn Pro Ser Arg Tyr Ile Ser Gly Leu Ser Lys Trp Val 
    850                 855                 860                 


Arg Gln Gln Ile Gln His His Ser Thr Phe Glu Ser Ala Leu Glu Ser 
865                 870                 875                 880 


Leu Ala Glu Phe Ser Lys Lys His Gln Lys Val Leu Asn Val Ser Ile 
                885                 890                 895     


Lys Asp Arg Thr Asn Ile Gln Asp Asn Glu Ser Thr Leu Glu Val Thr 
            900                 905                 910         


Ser Leu Lys Tyr Ser Thr Ser Pro Tyr Leu Leu Glu Ala Ala Ser His 
        915                 920                 925             


Leu Ser Pro Glu Asn Phe Val Glu Asp Glu Ala Lys Ile Cys Val Gln 
    930                 935                 940                 


Glu Leu Gln Cys Pro Lys Ile Ile Thr Lys Asn Ser Pro Leu Pro Ser 
945                 950                 955                 960 


Ser Ile Ile Ser Arg Lys Glu Lys Asn Asp Pro Val Phe Leu Glu Glu 
                965                 970                 975     


Ala Gly Lys Ala Glu Lys Ile Val Ile Ser Arg Ser Thr Ser Pro Thr 
            980                 985                 990         


Phe Asn Lys Gln Thr Lys Arg Val  Ser Trp Ser Ser Phe  Asn Ser Leu 
        995                 1000                 1005             


Gly Gln  Tyr Phe Thr Gly Lys  Ile Pro Lys Ala Thr  Pro Glu Leu 
    1010                 1015                 1020             


Gly Ser  Ser Glu Asn Ser Ala  Ser Ser Pro Pro Arg  Phe Lys Thr 
    1025                 1030                 1035             


Glu Lys  Met Glu Ser Lys Thr  Val Leu Pro Phe Thr  Asp Lys Cys 
    1040                 1045                 1050             


Glu Ser  Ser Asn Leu Thr Val  Asn Thr Ser Phe Gly  Ser Cys Pro 
    1055                 1060                 1065             


Gln Ser  Glu Thr Ile Ile Ser  Ser Leu Lys Ile Asp  Ala Thr Leu 
    1070                 1075                 1080             


Thr Arg  Lys Asn His Ser Glu  His Pro Leu Cys Ser  Glu Glu Ala 
    1085                 1090                 1095             


Leu Asp  Pro Asp Ile Glu Leu  Ser Leu Val Ser Glu  Glu Asp Lys 
    1100                 1105                 1110             


Gln Ser  Thr Ser Asn Arg Asp  Phe Glu Thr Glu Ala  Glu Asp Glu 
    1115                 1120                 1125             


Ser Ile  Tyr Phe Thr Pro Glu  Leu Tyr Asp Pro Glu  Asp Thr Asp 
    1130                 1135                 1140             


Glu Glu  Lys Asn Asp Leu Ala  Glu Thr Asp Arg Gly  Asn Arg Leu 
    1145                 1150                 1155             


Ala Asn  Asn Ser Asp Cys Ile  Leu Ala Lys Asp Leu  Phe Glu Ile 
    1160                 1165                 1170             


Arg Thr  Ile Lys Glu Val Asp  Ser Ala Arg Glu Val  Lys Ala Glu 
    1175                 1180                 1185             


Asp Cys  Ile Asp Thr Lys Leu  Asn Gly Ile Leu His  Ile Glu Glu 
    1190                 1195                 1200             


Ser Lys  Ile Asp Asp Ile Asp  Gly Asn Val Lys Thr  Thr Trp Ile 
    1205                 1210                 1215             


Asn Glu  Leu Glu Leu Gly Lys  Thr His Glu Ile Glu  Ile Lys Asn 
    1220                 1225                 1230             


Phe Lys  Pro Ser Pro Ser Lys  Asn Lys Gly Met Phe  Pro Gly Phe 
    1235                 1240                 1245             


Lys 
    


<210>  1245
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRK1__Homo_sapiens__NP_060932

<400>  1245

Met Ala Gly Gln Glu Asp Pro Val Gln Arg Glu Ile His Gln Asp Trp 
1               5                   10                  15      


Ala Asn Arg Glu Tyr Ile Glu Ile Ile Thr Ser Ser Ile Lys Lys Ile 
            20                  25                  30          


Ala Asp Phe Leu Asn Ser Phe Asp Met Ser Cys Arg Ser Arg Leu Ala 
        35                  40                  45              


Thr Leu Asn Glu Lys Leu Thr Ala Leu Glu Arg Arg Ile Glu Tyr Ile 
    50                  55                  60                  


Glu Ala Arg Val Thr Lys Gly Glu Thr Leu Thr 
65                  70                  75  


<210>  1246
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRMS1__Homo_sapiens__NP_001020128

<400>  1246

Met Pro Val Gln Pro Pro Ser Lys Asp Thr Glu Glu Met Glu Ala Glu 
1               5                   10                  15      


Gly Asp Ser Ala Ala Glu Met Asn Gly Glu Glu Glu Glu Ser Glu Glu 
            20                  25                  30          


Glu Arg Ser Gly Ser Gln Thr Glu Ser Glu Glu Glu Ser Ser Glu Met 
        35                  40                  45              


Asp Asp Glu Asp Tyr Glu Arg Arg Arg Ser Glu Cys Val Ser Glu Met 
    50                  55                  60                  


Leu Asp Leu Glu Lys Gln Phe Ser Glu Leu Lys Glu Lys Leu Phe Arg 
65                  70                  75                  80  


Glu Arg Leu Ser Gln Leu Arg Leu Arg Leu Glu Glu Val Gly Ala Glu 
                85                  90                  95      


Arg Ala Pro Glu Tyr Thr Glu Pro Leu Gly Gly Leu Gln Arg Ser Leu 
            100                 105                 110         


Lys Ile Arg Ile Gln Val Ala Gly Ile Tyr Lys Gly Phe Cys Leu Asp 
        115                 120                 125             


Val Ile Arg Asn Lys Tyr Glu Cys Glu Leu Gln Gly Ala Lys Gln His 
    130                 135                 140                 


Leu Glu Ser Glu Lys Leu Leu Leu Tyr Asp Thr Leu Gln Gly Glu Leu 
145                 150                 155                 160 


Gln Glu Arg Ile Gln Arg Leu Glu Glu Asp Arg Gln Ser Leu Asp Leu 
                165                 170                 175     


Ser Ser Glu Trp Trp Asp Asp Lys Leu His Ala Arg Gly Ser Ser Arg 
            180                 185                 190         


Ser Trp Asp Ser Leu Pro Pro Ser Lys Arg Lys Lys Ala Pro Leu Val 
        195                 200                 205             


Ser Gly Pro Tyr Ile Val Tyr Met Leu Gln Glu Ile Asp Ile Leu Glu 
    210                 215                 220                 


Asp Trp Thr Ala Ile Lys Lys Ala Arg Ala Ala Val Ser Pro Gln Lys 
225                 230                 235                 240 


Arg Lys Ser Asp Asp Arg Arg Thr His Arg Pro Leu Arg Val Cys Pro 
                245                 250                 255     


Ala Arg Leu Leu Trp Cys Cys Trp Ala Leu Pro Leu His Leu Ala Leu 
            260                 265                 270         


Ala Trp Thr Pro Pro Leu Pro Ser Ser Arg Pro Ala Gln Leu Trp Pro 
        275                 280                 285             


Trp Ser 
    290 


<210>  1247
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRMS1L__Homo_sapiens__NP_115728

<400>  1247

Met Pro Val His Ser Arg Gly Asp Lys Lys Glu Thr Asn His His Asp 
1               5                   10                  15      


Glu Met Glu Val Asp Tyr Ala Glu Asn Glu Gly Ser Ser Ser Glu Asp 
            20                  25                  30          


Glu Asp Thr Glu Ser Ser Ser Val Ser Glu Asp Gly Asp Ser Ser Glu 
        35                  40                  45              


Met Asp Asp Glu Asp Cys Glu Arg Arg Arg Met Glu Cys Leu Asp Glu 
    50                  55                  60                  


Met Ser Asn Leu Glu Lys Gln Phe Thr Asp Leu Lys Asp Gln Leu Tyr 
65                  70                  75                  80  


Lys Glu Arg Leu Ser Gln Val Asp Ala Lys Leu Gln Glu Val Ile Ala 
                85                  90                  95      


Gly Lys Ala Pro Glu Tyr Leu Glu Pro Leu Ala Thr Leu Gln Glu Asn 
            100                 105                 110         


Met Gln Ile Arg Thr Lys Val Ala Gly Ile Tyr Arg Glu Leu Cys Leu 
        115                 120                 125             


Glu Ser Val Lys Asn Lys Tyr Glu Cys Glu Ile Gln Ala Ser Arg Gln 
    130                 135                 140                 


His Cys Glu Ser Glu Lys Leu Leu Leu Tyr Asp Thr Val Gln Ser Glu 
145                 150                 155                 160 


Leu Glu Glu Lys Ile Arg Arg Leu Glu Glu Asp Arg His Ser Ile Asp 
                165                 170                 175     


Ile Thr Ser Glu Leu Trp Asn Asp Glu Leu Gln Ser Arg Lys Lys Arg 
            180                 185                 190         


Lys Asp Pro Phe Ser Pro Asp Lys Lys Lys Pro Val Val Val Ser Gly 
        195                 200                 205             


Pro Tyr Ile Val Tyr Met Leu Gln Asp Leu Asp Ile Leu Glu Asp Trp 
    210                 215                 220                 


Thr Thr Ile Arg Lys Ala Met Ala Thr Leu Gly Pro His Arg Val Lys 
225                 230                 235                 240 


Thr Glu Pro Pro Val Lys Leu Glu Lys His Leu His Ser Ala Arg Ser 
                245                 250                 255     


Glu Glu Gly Arg Leu Tyr Tyr Asp Gly Glu Trp Tyr Ile Arg Gly Gln 
            260                 265                 270         


Thr Ile Cys Ile Asp Lys Lys Asp Glu Cys Pro Thr Ser Ala Val Ile 
        275                 280                 285             


Thr Thr Ile Asn His Asp Glu Val Trp Phe Lys Arg Pro Asp Gly Ser 
    290                 295                 300                 


Lys Ser Lys Leu Tyr Ile Ser Gln Leu Gln Lys Gly Lys Tyr Ser Ile 
305                 310                 315                 320 


Lys His Ser 
            


<210>  1248
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRS3__Homo_sapiens__NP_001718

<400>  1248

Met Ala Gln Arg Gln Pro His Ser Pro Asn Gln Thr Leu Ile Ser Ile 
1               5                   10                  15      


Thr Asn Asp Thr Glu Ser Ser Ser Ser Val Val Ser Asn Asp Asn Thr 
            20                  25                  30          


Asn Lys Gly Trp Ser Gly Asp Asn Ser Pro Gly Ile Glu Ala Leu Cys 
        35                  40                  45              


Ala Ile Tyr Ile Thr Tyr Ala Val Ile Ile Ser Val Gly Ile Leu Gly 
    50                  55                  60                  


Asn Ala Ile Leu Ile Lys Val Phe Phe Lys Thr Lys Ser Met Gln Thr 
65                  70                  75                  80  


Val Pro Asn Ile Phe Ile Thr Ser Leu Ala Phe Gly Asp Leu Leu Leu 
                85                  90                  95      


Leu Leu Thr Cys Val Pro Val Asp Ala Thr His Tyr Leu Ala Glu Gly 
            100                 105                 110         


Trp Leu Phe Gly Arg Ile Gly Cys Lys Val Leu Ser Phe Ile Arg Leu 
        115                 120                 125             


Thr Ser Val Gly Val Ser Val Phe Thr Leu Thr Ile Leu Ser Ala Asp 
    130                 135                 140                 


Arg Tyr Lys Ala Val Val Lys Pro Leu Glu Arg Gln Pro Ser Asn Ala 
145                 150                 155                 160 


Ile Leu Lys Thr Cys Val Lys Ala Gly Cys Val Trp Ile Val Ser Met 
                165                 170                 175     


Ile Phe Ala Leu Pro Glu Ala Ile Phe Ser Asn Val Tyr Thr Phe Arg 
            180                 185                 190         


Asp Pro Asn Lys Asn Met Thr Phe Glu Ser Cys Thr Ser Tyr Pro Val 
        195                 200                 205             


Ser Lys Lys Leu Leu Gln Glu Ile His Ser Leu Leu Cys Phe Leu Val 
    210                 215                 220                 


Phe Tyr Ile Ile Pro Leu Ser Ile Ile Ser Val Tyr Tyr Ser Leu Ile 
225                 230                 235                 240 


Ala Arg Thr Leu Tyr Lys Ser Thr Leu Asn Ile Pro Thr Glu Glu Gln 
                245                 250                 255     


Ser His Ala Arg Lys Gln Ile Glu Ser Arg Lys Arg Ile Ala Arg Thr 
            260                 265                 270         


Val Leu Val Leu Val Ala Leu Phe Ala Leu Cys Trp Leu Pro Asn His 
        275                 280                 285             


Leu Leu Tyr Leu Tyr His Ser Phe Thr Ser Gln Thr Tyr Val Asp Pro 
    290                 295                 300                 


Ser Ala Met His Phe Ile Phe Thr Ile Phe Ser Arg Val Leu Ala Phe 
305                 310                 315                 320 


Ser Asn Ser Cys Val Asn Pro Phe Ala Leu Tyr Trp Leu Ser Lys Ser 
                325                 330                 335     


Phe Gln Lys His Phe Lys Ala Gln Leu Phe Cys Cys Lys Ala Glu Arg 
            340                 345                 350         


Pro Glu Pro Pro Val Ala Asp Thr Ser Leu Thr Thr Leu Ala Val Met 
        355                 360                 365             


Gly Thr Val Pro Gly Thr Gly Ser Ile Gln Met Ser Glu Ile Ser Val 
    370                 375                 380                 


Thr Ser Phe Thr Gly Cys Ser Val Lys Gln Ala Glu Asp Arg Phe 
385                 390                 395                 


<210>  1249
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRSK1__Homo_sapiens__NP_115806

<400>  1249

Met Ser Ser Gly Ala Lys Glu Gly Gly Gly Gly Ser Pro Ala Tyr His 
1               5                   10                  15      


Leu Pro His Pro His Pro His Pro Pro Gln His Ala Gln Tyr Val Gly 
            20                  25                  30          


Pro Tyr Arg Leu Glu Lys Thr Leu Gly Lys Gly Gln Thr Gly Leu Val 
        35                  40                  45              


Lys Leu Gly Val His Cys Ile Thr Gly Gln Lys Val Ala Ile Lys Ile 
    50                  55                  60                  


Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu Arg 
65                  70                  75                  80  


Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys Leu 
                85                  90                  95      


His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu His 
            100                 105                 110         


Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg Leu 
        115                 120                 125             


Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val Ser Ala Leu 
    130                 135                 140                 


Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu Lys Pro Glu 
145                 150                 155                 160 


Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe Gly 
                165                 170                 175     


Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys Gly 
            180                 185                 190         


Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu Lys Tyr Asp 
        195                 200                 205             


Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu Phe Ala Leu 
    210                 215                 220                 


Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu Leu 
225                 230                 235                 240 


Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro Pro 
                245                 250                 255     


Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu Pro Glu Lys 
            260                 265                 270         


Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr Leu Gly Gly 
        275                 280                 285             


Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly Arg Arg Val 
    290                 295                 300                 


Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro Asp Val Leu 
305                 310                 315                 320 


Glu Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu Arg Leu His 
                325                 330                 335     


Arg Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu Asp Gln Asp 
        355                 360                 365             


Leu Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg Val Asp Ser 
    370                 375                 380                 


Pro Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met 
385                 390                 395                 400 


Glu Val Leu Ser Ile Thr Asp Ala Gly Gly Gly Gly Ser Pro Val Pro 
                405                 410                 415     


Thr Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg Ser Arg Ser 
            420                 425                 430         


Val Ser Gly Ala Ser Thr Gly Leu Ser Ser Ser Pro Leu Ser Ser Pro 
        435                 440                 445             


Arg Ser Pro Val Phe Ser Phe Ser Pro Glu Pro Gly Ala Gly Asp Glu 
    450                 455                 460                 


Ala Arg Gly Gly Gly Ser Pro Thr Ser Lys Thr Gln Thr Leu Pro Ser 
465                 470                 475                 480 


Arg Gly Pro Arg Gly Gly Gly Ala Gly Glu Gln Pro Pro Pro Pro Ser 
                485                 490                 495     


Ala Arg Ser Thr Pro Leu Pro Gly Pro Pro Gly Ser Pro Arg Ser Ser 
            500                 505                 510         


Gly Gly Thr Pro Leu His Ser Pro Leu His Thr Pro Arg Ala Ser Pro 
        515                 520                 525             


Thr Gly Thr Pro Gly Thr Thr Pro Pro Pro Ser Pro Gly Gly Gly Val 
    530                 535                 540                 


Gly Gly Ala Ala Trp Arg Ser Arg Leu Asn Ser Ile Arg Asn Ser Phe 
545                 550                 555                 560 


Leu Gly Ser Pro Arg Phe His Arg Arg Lys Met Gln Val Pro Thr Ala 
                565                 570                 575     


Glu Glu Met Ser Ser Leu Thr Pro Glu Ser Ser Pro Glu Leu Ala Lys 
            580                 585                 590         


Arg Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu Glu Gln Ile 
        595                 600                 605             


Phe Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys Ala Asp Ile 
    610                 615                 620                 


Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser Val Leu Ser 
625                 630                 635                 640 


Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly Pro Ser Val 
                645                 650                 655     


Phe Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser Ser Glu Gly 
            660                 665                 670         


Pro Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly Gly Ile Tyr 
        675                 680                 685             


Ser Val Thr Phe Thr Leu Ile Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    690                 695                 700                 


Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Gln Pro 
705                 710                 715                 720 


Ser Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln Thr Arg Pro 
                725                 730                 735     


Ala Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly Arg Pro Asp 
            740                 745                 750         


Pro Glu Leu Ser Ser Ser Pro Arg Arg Gly Pro Pro Lys Asp Lys Lys 
        755                 760                 765             


Leu Leu Ala Thr Asn Gly Thr Pro Leu Pro 
    770                 775             


<210>  1250
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRSK2__Homo_sapiens__NP_001243556

<400>  1250

Met Thr Ser Thr Gly Lys Asp Gly Gly Ala Gln His Ala Gln Tyr Val 
1               5                   10                  15      


Gly Pro Tyr Arg Leu Glu Lys Thr Leu Gly Lys Gly Gln Thr Gly Leu 
            20                  25                  30          


Val Lys Leu Gly Val His Cys Val Thr Cys Gln Lys Val Ala Ile Lys 
        35                  40                  45              


Ile Val Asn Arg Glu Lys Leu Ser Glu Ser Val Leu Met Lys Val Glu 
    50                  55                  60                  


Arg Glu Ile Ala Ile Leu Lys Leu Ile Glu His Pro His Val Leu Lys 
65                  70                  75                  80  


Leu His Asp Val Tyr Glu Asn Lys Lys Tyr Leu Tyr Leu Val Leu Glu 
                85                  90                  95      


His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys Gly Arg 
            100                 105                 110         


Leu Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Ile Ser Ala 
        115                 120                 125             


Leu Asp Phe Cys His Ser His Ser Ile Cys His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala Asp Phe 
145                 150                 155                 160 


Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr Ser Cys 
                165                 170                 175     


Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Arg Gly Glu Lys Tyr 
            180                 185                 190         


Asp Gly Arg Lys Ala Asp Val Trp Ser Cys Gly Val Ile Leu Phe Ala 
        195                 200                 205             


Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg Gln Leu 
    210                 215                 220                 


Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe Ile Pro 
225                 230                 235                 240 


Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Arg Arg Leu Thr Leu Glu His Ile Gln Lys His Ile Trp Tyr Ile Gly 
            260                 265                 270         


Gly Lys Asn Glu Pro Glu Pro Glu Gln Pro Ile Pro Arg Lys Val Gln 
        275                 280                 285             


Ile Arg Ser Leu Pro Ser Leu Glu Asp Ile Asp Pro Asp Val Leu Asp 
    290                 295                 300                 


Ser Met His Ser Leu Gly Cys Phe Arg Asp Arg Asn Lys Leu Leu Gln 
305                 310                 315                 320 


Asp Leu Leu Ser Glu Glu Glu Asn Gln Glu Lys Met Ile Tyr Phe Leu 
                325                 330                 335     


Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Gln Glu Asp Glu Asp Leu 
            340                 345                 350         


Pro Pro Arg Asn Glu Ile Asp Pro Pro Arg Lys Arg Val Asp Ser Pro 
        355                 360                 365             


Met Leu Asn Arg His Gly Lys Arg Arg Pro Glu Arg Lys Ser Met Glu 
    370                 375                 380                 


Val Leu Ser Val Thr Asp Gly Gly Ser Pro Val Pro Ala Arg Arg Ala 
385                 390                 395                 400 


Ile Glu Met Ala Gln His Gly Gln Arg Ser Arg Ser Ile Ser Gly Ala 
                405                 410                 415     


Ser Ser Gly Leu Ser Thr Ser Pro Leu Ser Ser Pro Arg Val Thr Pro 
            420                 425                 430         


His Pro Ser Pro Arg Gly Ser Pro Leu Pro Thr Pro Lys Gly Thr Pro 
        435                 440                 445             


Val His Thr Pro Lys Glu Ser Pro Ala Gly Thr Pro Asn Pro Thr Pro 
    450                 455                 460                 


Pro Ser Ser Pro Ser Val Gly Gly Val Pro Trp Arg Ala Arg Leu Asn 
465                 470                 475                 480 


Ser Ile Lys Asn Ser Phe Leu Gly Ser Pro Arg Phe His Arg Arg Lys 
                485                 490                 495     


Leu Gln Val Pro Thr Pro Glu Glu Met Ser Asn Leu Thr Pro Glu Ser 
            500                 505                 510         


Ser Pro Glu Leu Ala Lys Lys Ser Trp Phe Gly Asn Phe Ile Ser Leu 
        515                 520                 525             


Glu Lys Glu Glu Gln Ile Phe Val Val Ile Lys Asp Lys Pro Leu Ser 
    530                 535                 540                 


Ser Ile Lys Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu 
545                 550                 555                 560 


Ser His Ser Val Ile Ser Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala 
                565                 570                 575     


Thr Gly Gly Pro Ala Val Phe Gln Lys Pro Val Lys Phe Gln Val Asp 
            580                 585                 590         


Ile Thr Tyr Thr Glu Gly Gly Glu Ala Gln Lys Glu Asn Gly Ile Tyr 
        595                 600                 605             


Ser Val Thr Phe Thr Leu Leu Ser Gly Pro Ser Arg Arg Phe Lys Arg 
    610                 615                 620                 


Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His Asp Pro Pro 
625                 630                 635                 640 


Ala Ala Gln His Leu Ser Asp Thr Thr Asn Cys Met Glu Met Met Thr 
                645                 650                 655     


Gly Arg Leu Ser Lys Cys Gly Ser Pro Leu Ser Asn Phe Phe Asp Val 
            660                 665                 670         


Ile Lys Gln Leu Phe Ser Asp Glu Lys Asn Gly Gln Ala Ala Gln Ala 
        675                 680                 685             


Pro Ser Thr Pro Ala Lys Arg Ser Ala His Gly Pro Leu Gly Asp Ser 
    690                 695                 700                 


Ala Ala Ala Gly Pro Gly Pro Gly Gly Asp Ala Glu Tyr Pro Thr Gly 
705                 710                 715                 720 


Lys Asp Thr Ala Lys Met Gly Pro Pro Thr Ala Arg Arg Glu Gln Pro 
                725                 730                 735     


<210>  1251
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRWD1__Homo_sapiens__NP_001007247

<400>  1251

Met Ala Glu Pro Ser Ser Ala Arg Arg Pro Val Pro Leu Ile Glu Ser 
1               5                   10                  15      


Glu Leu Tyr Phe Leu Ile Ala Arg Tyr Leu Ser Ala Gly Pro Cys Arg 
            20                  25                  30          


Arg Ala Ala Gln Val Leu Val Gln Glu Leu Glu Gln Tyr Gln Leu Leu 
        35                  40                  45              


Pro Lys Arg Leu Asp Trp Glu Gly Asn Glu His Asn Arg Ser Tyr Glu 
    50                  55                  60                  


Glu Leu Val Leu Ser Asn Lys His Val Ala Pro Asp His Leu Leu Gln 
65                  70                  75                  80  


Ile Cys Gln Arg Ile Gly Pro Met Leu Asp Lys Glu Ile Pro Pro Ser 
                85                  90                  95      


Ile Ser Arg Val Thr Ser Leu Leu Gly Ala Gly Arg Gln Ser Leu Leu 
            100                 105                 110         


Arg Thr Ala Lys Gly Thr Leu Ile 
        115                 120 


<210>  1252
<211>  1802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRWD3__Homo_sapiens__NP_694984

<400>  1252

Met Ala Ala Ala Pro Thr Gln Ile Glu Ala Glu Leu Tyr Tyr Leu Ile 
1               5                   10                  15      


Ala Arg Phe Leu Gln Ser Gly Pro Cys Asn Lys Ser Ala Gln Val Leu 
            20                  25                  30          


Val Gln Glu Leu Glu Glu His Gln Leu Ile Pro Arg Arg Leu Asp Trp 
        35                  40                  45              


Glu Gly Lys Glu His Arg Arg Ser Phe Glu Asp Leu Val Ala Ala Asn 
    50                  55                  60                  


Ala His Ile Pro Pro Asp Tyr Leu Leu Lys Ile Cys Glu Arg Ile Gly 
65                  70                  75                  80  


Pro Leu Leu Asp Lys Glu Ile Pro Gln Ser Val Pro Gly Val Gln Thr 
                85                  90                  95      


Leu Leu Gly Val Gly Arg Gln Ser Leu Leu Arg Asp Ala Lys Asp Cys 
            100                 105                 110         


Lys Ser Thr Leu Trp Asn Gly Ser Ala Phe Ala Ala Leu His Arg Gly 
        115                 120                 125             


Arg Pro Pro Glu Leu Pro Val Asn Tyr Val Lys Pro Pro Asn Val Val 
    130                 135                 140                 


Asn Ile Thr Ser Ala Arg Gln Leu Thr Gly Cys Ser Arg Phe Gly His 
145                 150                 155                 160 


Ile Phe Pro Ser Ser Ala Tyr Gln His Ile Lys Met His Lys Arg Ile 
                165                 170                 175     


Leu Gly His Leu Ser Ser Val Tyr Cys Val Ala Phe Asp Arg Ser Gly 
            180                 185                 190         


Arg Arg Ile Phe Thr Gly Ser Asp Asp Cys Leu Val Lys Ile Trp Ala 
        195                 200                 205             


Thr Asp Asp Gly Arg Leu Leu Ala Thr Leu Arg Gly His Ser Ala Glu 
    210                 215                 220                 


Ile Ser Asp Met Ala Val Asn Tyr Glu Asn Thr Leu Ile Ala Ala Gly 
225                 230                 235                 240 


Ser Cys Asp Lys Val Val Arg Val Trp Cys Leu Arg Thr Cys Ala Pro 
                245                 250                 255     


Val Ala Val Leu Gln Gly His Ser Ala Ser Ile Thr Ser Ile Gln Phe 
            260                 265                 270         


Cys Pro Ser Thr Lys Gly Thr Asn Arg Tyr Leu Thr Ser Thr Gly Ala 
        275                 280                 285             


Asp Gly Thr Ile Cys Phe Trp Gln Trp His Val Lys Thr Met Lys Phe 
    290                 295                 300                 


Arg Asp Arg Pro Val Lys Phe Thr Glu Arg Ser Arg Pro Gly Val Gln 
305                 310                 315                 320 


Ile Ser Cys Ser Ser Phe Ser Ser Gly Gly Met Phe Ile Thr Thr Gly 
                325                 330                 335     


Ser Thr Asp His Val Ile Arg Ile Tyr Tyr Leu Gly Ser Glu Val Pro 
            340                 345                 350         


Glu Lys Ile Ala Glu Leu Glu Ser His Thr Asp Lys Val Val Ala Val 
        355                 360                 365             


Gln Phe Cys Asn Asn Gly Asp Ser Leu Arg Phe Val Ser Gly Ser Arg 
    370                 375                 380                 


Asp Gly Thr Ala Arg Ile Trp Gln Tyr Gln Gln Gln Glu Trp Lys Ser 
385                 390                 395                 400 


Ile Val Leu Asp Met Ala Thr Lys Met Thr Gly Asn Asn Leu Pro Ser 
                405                 410                 415     


Gly Glu Asp Lys Ile Thr Lys Leu Lys Val Thr Met Val Ala Trp Asp 
            420                 425                 430         


Arg Tyr Asp Thr Thr Val Ile Thr Ala Val Asn Asn Phe Leu Leu Lys 
        435                 440                 445             


Val Trp Asn Ser Ile Thr Gly Gln Leu Leu His Thr Leu Ser Gly His 
    450                 455                 460                 


Asp Asp Glu Val Phe Val Leu Glu Ala His Pro Phe Asp Gln Arg Ile 
465                 470                 475                 480 


Ile Leu Ser Ala Gly His Asp Gly Asn Ile Phe Ile Trp Asp Leu Asp 
                485                 490                 495     


Arg Gly Thr Lys Ile Arg Asn Tyr Phe Asn Met Ile Glu Gly Gln Gly 
            500                 505                 510         


His Gly Ala Val Phe Asp Cys Lys Phe Ser Pro Asp Gly Asn His Phe 
        515                 520                 525             


Ala Cys Thr Asp Ser His Gly His Leu Leu Leu Phe Gly Phe Gly Cys 
    530                 535                 540                 


Ser Lys Tyr Tyr Glu Lys Ile Pro Asp Gln Met Phe Phe His Thr Asp 
545                 550                 555                 560 


Tyr Arg Pro Leu Ile Arg Asp Ala Asn Asn Tyr Val Leu Asp Glu Gln 
                565                 570                 575     


Thr Gln Gln Ala Pro His Leu Met Pro Pro Pro Phe Leu Val Asp Val 
            580                 585                 590         


Asp Gly Asn Pro His Pro Thr Lys Phe Gln Arg Leu Val Pro Gly Arg 
        595                 600                 605             


Glu Asn Cys Lys Asp Glu Gln Leu Ile Pro Gln Leu Gly Tyr Val Ala 
    610                 615                 620                 


Asn Gly Asp Gly Glu Val Val Glu Gln Val Ile Gly Gln Gln Thr Asn 
625                 630                 635                 640 


Asp Gln Asp Glu Ser Ile Leu Asp Gly Ile Ile Arg Glu Leu Gln Arg 
                645                 650                 655     


Glu Gln Asp Leu Arg Leu Ile Asn Glu Gly Asp Val Pro His Leu Pro 
            660                 665                 670         


Val Asn Arg Ala Tyr Ser Val Asn Gly Ala Leu Arg Ser Pro Asn Met 
        675                 680                 685             


Asp Ile Ser Ser Ser Pro Asn Ile Arg Leu Arg Arg His Ser Ser Gln 
    690                 695                 700                 


Ile Glu Gly Val Arg Gln Met His Asn Asn Ala Pro Arg Ser Gln Met 
705                 710                 715                 720 


Ala Thr Glu Arg Asp Leu Met Ala Trp Ser Arg Arg Val Val Val Asn 
                725                 730                 735     


Glu Leu Asn Asn Gly Val Ser Arg Val Gln Glu Glu Cys Arg Thr Ala 
            740                 745                 750         


Lys Gly Asp Ile Glu Ile Ser Leu Tyr Thr Val Glu Lys Lys Lys Lys 
        755                 760                 765             


Pro Ser Tyr Thr Thr Gln Arg Asn Asp Tyr Glu Pro Ser Cys Gly Arg 
    770                 775                 780                 


Ser Leu Arg Arg Thr Gln Arg Lys Arg Gln His Thr Tyr Gln Thr Arg 
785                 790                 795                 800 


Ser Asn Ile Glu His Asn Ser Gln Ala Ser Cys Gln Asn Ser Gly Val 
                805                 810                 815     


Gln Glu Asp Ser Asp Ser Ser Ser Glu Glu Asp Glu Thr Val Gly Thr 
            820                 825                 830         


Ser Asp Ala Ser Val Glu Asp Pro Val Val Glu Trp Gln Ser Glu Ser 
        835                 840                 845             


Ser Ser Ser Asp Ser Ser Ser Glu Tyr Ser Asp Trp Thr Ala Asp Ala 
    850                 855                 860                 


Gly Ile Asn Leu Gln Pro Pro Lys Arg Gln Thr Arg Gln Thr Thr Arg 
865                 870                 875                 880 


Lys Ile Cys Ser Ser Ser Asp Glu Glu Asn Leu Lys Ser Leu Glu Glu 
                885                 890                 895     


Arg Gln Lys Lys Pro Lys Gln Thr Arg Lys Lys Lys Gly Gly Leu Val 
            900                 905                 910         


Ser Ile Ala Gly Glu Pro Asn Glu Glu Trp Phe Ala Pro Gln Trp Ile 
        915                 920                 925             


Leu Asp Thr Ile Pro Arg Arg Ser Pro Phe Val Pro Gln Met Gly Asp 
    930                 935                 940                 


Glu Leu Ile Tyr Phe Arg Gln Gly His Glu Ala Tyr Val Arg Ala Val 
945                 950                 955                 960 


Arg Lys Ser Lys Ile Tyr Ser Val Asn Leu Gln Lys Gln Pro Trp Asn 
                965                 970                 975     


Lys Met Asp Leu Arg Glu Gln Glu Phe Val Lys Ile Val Gly Ile Lys 
            980                 985                 990         


Tyr Glu Val Gly Pro Pro Thr Leu  Cys Cys Leu Lys Leu  Ala Phe Leu 
        995                 1000                 1005             


Asp Pro  Ile Ser Gly Lys Met  Thr Gly Glu Ser Phe  Ser Ile Lys 
    1010                 1015                 1020             


Tyr His  Asp Met Pro Asp Val  Ile Asp Phe Leu Val  Leu His Gln 
    1025                 1030                 1035             


Phe Tyr  Asn Glu Ala Lys Glu  Arg Asn Trp Gln Ile  Gly Asp Arg 
    1040                 1045                 1050             


Phe Arg  Ser Ile Ile Asp Asp  Ala Trp Trp Phe Gly  Thr Val Glu 
    1055                 1060                 1065             


Ser Gln  Gln Pro Phe Gln Pro  Glu Tyr Pro Asp Ser  Ser Phe Gln 
    1070                 1075                 1080             


Cys Tyr  Ser Val His Trp Asp  Asn Asn Glu Arg Glu  Lys Met Ser 
    1085                 1090                 1095             


Pro Trp  Asp Met Glu Pro Ile  Pro Glu Gly Thr Ala  Phe Pro Asp 
    1100                 1105                 1110             


Glu Val  Gly Ala Gly Val Pro  Val Ser Gln Glu Glu  Leu Thr Ala 
    1115                 1120                 1125             


Leu Leu  Tyr Lys Pro Gln Glu  Gly Glu Trp Gly Ala  His Ser Arg 
    1130                 1135                 1140             


Asp Glu  Glu Cys Glu Arg Val  Ile Gln Gly Ile Asn  His Leu Leu 
    1145                 1150                 1155             


Ser Leu  Asp Phe Ala Ser Pro  Phe Ala Val Pro Val  Asp Leu Ser 
    1160                 1165                 1170             


Ala Tyr  Pro Leu Tyr Cys Thr  Val Val Ala Tyr Pro  Thr Asp Leu 
    1175                 1180                 1185             


Asn Thr  Ile Arg Arg Arg Leu  Glu Asn Arg Phe Tyr  Arg Arg Ile 
    1190                 1195                 1200             


Ser Ala  Leu Met Trp Glu Val  Arg Tyr Ile Glu His  Asn Ala Arg 
    1205                 1210                 1215             


Thr Phe  Asn Glu Pro Asp Ser  Pro Ile Val Lys Ala  Ala Lys Ile 
    1220                 1225                 1230             


Val Thr  Asp Val Leu Leu Arg  Phe Ile Gly Asp Gln  Ser Cys Thr 
    1235                 1240                 1245             


Asp Ile  Leu Asp Thr Tyr Asn  Lys Ile Lys Ala Glu  Glu Arg Asn 
    1250                 1255                 1260             


Ser Thr  Asp Ala Glu Glu Asp  Thr Glu Ile Val Asp  Leu Asp Ser 
    1265                 1270                 1275             


Asp Gly  Pro Gly Thr Ser Ser  Gly Arg Arg Val Lys  Cys Arg Gly 
    1280                 1285                 1290             


Arg Arg  Gln Ser Leu Lys Cys  Asn Pro Asp Ala Trp  Lys Lys Gln 
    1295                 1300                 1305             


Cys Lys  Glu Leu Leu Ser Leu  Ile Tyr Glu Arg Glu  Asp Ser Glu 
    1310                 1315                 1320             


Pro Phe  Arg Gln Pro Ala Asp  Leu Leu Ser Tyr Pro  Gly His Gln 
    1325                 1330                 1335             


Glu Gln  Glu Gly Glu Ser Ser  Glu Ser Val Val Pro  Glu Arg Gln 
    1340                 1345                 1350             


Gln Asp  Ser Ser Leu Ser Glu  Asp Tyr Gln Asp Val  Ile Asp Thr 
    1355                 1360                 1365             


Pro Val  Asp Phe Ser Thr Val  Lys Glu Thr Leu Glu  Ala Gly Asn 
    1370                 1375                 1380             


Tyr Gly  Ser Pro Leu Glu Phe  Tyr Lys Asp Val Arg  Gln Ile Phe 
    1385                 1390                 1395             


Asn Asn  Ser Lys Ala Tyr Thr  Ser Asn Lys Lys Ser  Arg Ile Tyr 
    1400                 1405                 1410             


Ser Met  Met Leu Arg Leu Ser  Ala Leu Phe Glu Ser  His Ile Lys 
    1415                 1420                 1425             


Asn Ile  Ile Ser Glu Tyr Lys  Ser Ala Ile Gln Ser  Gln Lys Arg 
    1430                 1435                 1440             


Arg Arg  Pro Arg Tyr Arg Lys  Arg Leu Arg Ser Ser  Ser Ser Ser 
    1445                 1450                 1455             


Leu Ser  Ser Ser Gly Ala Pro  Ser Pro Lys Gly Lys  Gln Lys Gln 
    1460                 1465                 1470             


Met Lys  Leu Gln Pro Lys Asn  Asp Gln Asn Thr Ser  Val Ser His 
    1475                 1480                 1485             


Ala Arg  Thr Ser Ser Pro Phe  Ser Ser Pro Val Ser  Asp Ala Ala 
    1490                 1495                 1500             


Glu Gly  Leu Ser Leu Tyr Leu  Leu Asp Asp Glu Pro  Asp Gly Pro 
    1505                 1510                 1515             


Phe Ser  Ser Ser Ser Phe Gly  Gly Tyr Ser Arg Ser  Gly Asn Ser 
    1520                 1525                 1530             


His Asp  Pro Gly Lys Ala Lys  Ser Phe Arg Asn Arg  Val Leu Pro 
    1535                 1540                 1545             


Val Lys  Gln Asp His Ser Leu  Asp Gly Pro Leu Thr  Asn Gly Asp 
    1550                 1555                 1560             


Gly Arg  Glu Pro Arg Thr Gly  Ile Lys Arg Lys Leu  Leu Ser Ala 
    1565                 1570                 1575             


Ser Glu  Glu Asp Glu Asn Met  Gly Gly Glu Asp Lys  Glu Lys Lys 
    1580                 1585                 1590             


Glu Thr  Lys Glu Lys Ser His  Leu Ser Thr Ser Glu  Ser Gly Glu 
    1595                 1600                 1605             


Leu Gly  Ser Ser Leu Ser Ser  Glu Ser Thr Cys Gly  Ser Asp Ser 
    1610                 1615                 1620             


Asp Ser  Glu Ser Thr Ser Arg  Thr Asp Gln Asp Tyr  Val Asp Gly 
    1625                 1630                 1635             


Asp His  Asp Tyr Ser Lys Phe  Ile Gln Thr Arg Pro  Lys Arg Lys 
    1640                 1645                 1650             


Leu Arg  Lys Gln His Gly Asn  Gly Lys Arg Asn Trp  Lys Thr Arg 
    1655                 1660                 1665             


Gly Thr  Gly Gly Arg Gly Arg  Trp Gly Arg Trp Gly  Arg Trp Ser 
    1670                 1675                 1680             


Arg Gly  Gly Arg Gly Arg Gly  Gly Arg Gly Arg Gly  Ser Arg Gly 
    1685                 1690                 1695             


Arg Gly  Gly Gly Gly Thr Arg  Gly Arg Gly Arg Gly  Arg Gly Gly 
    1700                 1705                 1710             


Arg Gly  Ala Ser Arg Gly Ala  Thr Arg Ala Lys Arg  Ala Arg Ile 
    1715                 1720                 1725             


Ala Asp  Asp Glu Phe Asp Thr  Met Phe Ser Gly Arg  Phe Ser Arg 
    1730                 1735                 1740             


Leu Pro  Arg Ile Lys Thr Arg  Asn Gln Gly Arg Arg  Thr Val Leu 
    1745                 1750                 1755             


Tyr Asn  Asp Asp Ser Asp Asn  Asp Asn Phe Val Ser  Thr Glu Asp 
    1760                 1765                 1770             


Pro Leu  Asn Leu Gly Thr Ser  Arg Ser Gly Arg Val  Arg Lys Met 
    1775                 1780                 1785             


Thr Glu  Lys Ala Arg Val Ser  His Leu Met Gly Trp  Asn Tyr 
    1790                 1795                 1800         


<210>  1253
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSCL2__Homo_sapiens__NP_001116427

<400>  1253

Met Ser Thr Glu Lys Val Asp Gln Lys Glu Glu Ala Gly Glu Lys Glu 
1               5                   10                  15      


Val Cys Gly Asp Gln Ile Lys Gly Pro Asp Lys Glu Glu Glu Pro Pro 
            20                  25                  30          


Ala Ala Ala Ser His Gly Gln Gly Trp Arg Pro Gly Gly Arg Ala Ala 
        35                  40                  45              


Arg Asn Ala Arg Pro Glu Pro Gly Ala Arg His Pro Ala Leu Pro Ala 
    50                  55                  60                  


Met Val Asn Asp Pro Pro Val Pro Ala Leu Leu Trp Ala Gln Glu Val 
65                  70                  75                  80  


Gly Gln Val Leu Ala Gly Arg Ala Arg Arg Leu Leu Leu Gln Phe Gly 
                85                  90                  95      


Val Leu Phe Cys Thr Ile Leu Leu Leu Leu Trp Val Ser Val Phe Leu 
            100                 105                 110         


Tyr Gly Ser Phe Tyr Tyr Ser Tyr Met Pro Thr Val Ser His Leu Ser 
        115                 120                 125             


Pro Val His Phe Tyr Tyr Arg Thr Asp Cys Asp Ser Ser Thr Thr Ser 
    130                 135                 140                 


Leu Cys Ser Phe Pro Val Ala Asn Val Ser Leu Thr Lys Gly Gly Arg 
145                 150                 155                 160 


Asp Arg Val Leu Met Tyr Gly Gln Pro Tyr Arg Val Thr Leu Glu Leu 
                165                 170                 175     


Glu Leu Pro Glu Ser Pro Val Asn Gln Asp Leu Gly Met Phe Leu Val 
            180                 185                 190         


Thr Ile Ser Cys Tyr Thr Arg Gly Gly Arg Ile Ile Ser Thr Ser Ser 
        195                 200                 205             


Arg Ser Val Met Leu His Tyr Arg Ser Asp Leu Leu Gln Met Leu Asp 
    210                 215                 220                 


Thr Leu Val Phe Ser Ser Leu Leu Leu Phe Gly Phe Ala Glu Gln Lys 
225                 230                 235                 240 


Gln Leu Leu Glu Val Glu Leu Tyr Ala Asp Tyr Arg Glu Asn Ser Tyr 
                245                 250                 255     


Val Pro Thr Thr Gly Ala Ile Ile Glu Ile His Ser Lys Arg Ile Gln 
            260                 265                 270         


Leu Tyr Gly Ala Tyr Leu Arg Ile His Ala His Phe Thr Gly Leu Arg 
        275                 280                 285             


Tyr Leu Leu Tyr Asn Phe Pro Met Thr Cys Ala Phe Ile Gly Val Ala 
    290                 295                 300                 


Ser Asn Phe Thr Phe Leu Ser Val Ile Val Leu Phe Ser Tyr Met Gln 
305                 310                 315                 320 


Trp Val Trp Gly Gly Ile Trp Pro Arg His Arg Phe Ser Leu Gln Val 
                325                 330                 335     


Asn Ile Arg Lys Arg Asp Asn Ser Arg Lys Glu Val Gln Arg Arg Ile 
            340                 345                 350         


Ser Ala His Gln Pro Gly Pro Glu Gly Gln Glu Glu Ser Thr Pro Gln 
        355                 360                 365             


Ser Asp Val Thr Glu Asp Gly Glu Ser Pro Glu Asp Pro Ser Gly Thr 
    370                 375                 380                 


Glu Gly Gln Leu Ser Glu Glu Glu Lys Pro Asp Gln Gln Pro Leu Ser 
385                 390                 395                 400 


Gly Glu Glu Glu Leu Glu Pro Glu Ala Ser Asp Gly Ser Gly Ser Trp 
                405                 410                 415     


Glu Asp Ala Ala Leu Leu Thr Glu Ala Asn Leu Pro Ala Pro Ala Pro 
            420                 425                 430         


Ala Ser Ala Ser Ala Pro Val Leu Glu Thr Leu Gly Ser Ser Glu Pro 
        435                 440                 445             


Ala Gly Gly Ala Leu Arg Gln Arg Pro Thr Cys Ser Ser Ser 
    450                 455                 460         


<210>  1254
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSG__Homo_sapiens__NP_001719

<400>  1254

Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 
1               5                   10                  15      


His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 
            20                  25                  30          


Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 
        35                  40                  45              


Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 
    50                  55                  60                  


Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 
65                  70                  75                  80  


Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 
            100                 105                 110         


Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 
        115                 120                 125             


Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 
    130                 135                 140                 


Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 
145                 150                 155                 160 


Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 
                165                 170                 175     


Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 
            180                 185                 190         


Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 
        195                 200                 205             


Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 
    210                 215                 220                 


Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 
225                 230                 235                 240 


Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 
                245                 250                 255     


Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 
            260                 265                 270         


Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 
        275                 280                 285             


Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 
    290                 295                 300                 


Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 
305                 310                 315                 320 


His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 
                325                 330                 335     


Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 
            340                 345                 350         


Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 
        355                 360                 365             


Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 
    370                 375                 380                 


Ser 
385 


<210>  1255
<211>  3926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSN__Homo_sapiens__NP_003449

<400>  1255

Met Gly Asn Glu Val Ser Leu Glu Gly Gly Ala Gly Asp Gly Pro Leu 
1               5                   10                  15      


Pro Pro Gly Gly Ala Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly 
            20                  25                  30          


Ala Gly Lys Pro Pro Ser Ala Pro Ala Gly Gly Gly Gln Leu Pro Ala 
        35                  40                  45              


Ala Gly Ala Ala Arg Ser Thr Ala Val Pro Pro Val Pro Gly Pro Gly 
    50                  55                  60                  


Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ser Thr Ser Arg Arg Leu 
65                  70                  75                  80  


Asp Pro Lys Glu Pro Leu Gly Asn Gln Arg Ala Ala Ser Pro Thr Pro 
                85                  90                  95      


Lys Gln Ala Ser Ala Thr Thr Pro Gly His Glu Ser Pro Arg Glu Thr 
            100                 105                 110         


Arg Ala Gln Gly Pro Ala Gly Gln Glu Ala Asp Gly Pro Arg Arg Thr 
        115                 120                 125             


Leu Gln Val Asp Ser Arg Thr Gln Arg Ser Gly Arg Ser Pro Ser Val 
    130                 135                 140                 


Ser Pro Asp Arg Gly Ser Thr Pro Thr Ser Pro Tyr Ser Val Pro Gln 
145                 150                 155                 160 


Ile Ala Pro Leu Pro Ser Ser Thr Leu Cys Pro Ile Cys Lys Thr Ser 
                165                 170                 175     


Asp Leu Thr Ser Thr Pro Ser Gln Pro Asn Phe Asn Thr Cys Thr Gln 
            180                 185                 190         


Cys His Asn Lys Val Cys Asn Gln Cys Gly Phe Asn Pro Asn Pro His 
        195                 200                 205             


Leu Thr Gln Val Lys Glu Trp Leu Cys Leu Asn Cys Gln Met Gln Arg 
    210                 215                 220                 


Ala Leu Gly Met Asp Met Thr Thr Ala Pro Arg Ser Lys Ser Gln Gln 
225                 230                 235                 240 


Gln Leu His Ser Pro Ala Leu Ser Pro Ala His Ser Pro Ala Lys Gln 
                245                 250                 255     


Pro Leu Gly Lys Pro Asp Gln Glu Arg Ser Arg Gly Pro Gly Gly Pro 
            260                 265                 270         


Gln Pro Gly Ser Arg Gln Ala Glu Thr Ala Arg Ala Thr Ser Val Pro 
        275                 280                 285             


Gly Pro Ala Gln Ala Ala Ala Pro Pro Glu Val Gly Arg Val Ser Pro 
    290                 295                 300                 


Gln Pro Pro Gln Pro Thr Lys Pro Ser Thr Ala Glu Pro Arg Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Ala Pro Ala Lys Ser Ala Thr Ala Val Pro Ala Gly Leu 
                325                 330                 335     


Gly Ala Thr Glu Gln Thr Gln Glu Gly Leu Thr Gly Lys Leu Phe Gly 
            340                 345                 350         


Leu Gly Ala Ser Leu Leu Thr Gln Ala Ser Thr Leu Met Ser Val Gln 
        355                 360                 365             


Pro Glu Ala Asp Thr Gln Gly Gln Pro Ala Pro Ser Lys Gly Thr Pro 
    370                 375                 380                 


Lys Ile Val Phe Asn Asp Ala Ser Lys Glu Ala Gly Pro Lys Pro Leu 
385                 390                 395                 400 


Gly Ser Gly Pro Gly Pro Gly Pro Ala Pro Gly Ala Lys Thr Glu Pro 
                405                 410                 415     


Gly Ala Arg Met Gly Pro Gly Ser Gly Pro Gly Ala Leu Pro Lys Thr 
            420                 425                 430         


Gly Gly Thr Thr Ser Pro Lys His Gly Arg Ala Glu His Gln Ala Ala 
        435                 440                 445             


Ser Lys Ala Ala Ala Lys Pro Lys Thr Met Pro Lys Glu Arg Ala Ile 
    450                 455                 460                 


Cys Pro Leu Cys Gln Ala Glu Leu Asn Val Gly Ser Lys Ser Pro Ala 
465                 470                 475                 480 


Asn Tyr Asn Thr Cys Thr Thr Cys Arg Leu Gln Val Cys Asn Leu Cys 
                485                 490                 495     


Gly Phe Asn Pro Thr Pro His Leu Val Glu Lys Thr Glu Trp Leu Cys 
            500                 505                 510         


Leu Asn Cys Gln Thr Lys Arg Leu Leu Glu Gly Ser Leu Gly Glu Pro 
        515                 520                 525             


Thr Pro Leu Pro Pro Pro Thr Ser Gln Gln Pro Pro Val Gly Ala Pro 
    530                 535                 540                 


His Arg Ala Ser Gly Thr Ser Pro Leu Lys Gln Lys Gly Pro Gln Gly 
545                 550                 555                 560 


Leu Gly Gln Pro Ser Gly Pro Leu Pro Ala Lys Ala Ser Pro Leu Ser 
                565                 570                 575     


Thr Lys Ala Ser Pro Leu Pro Ser Lys Ala Ser Pro Gln Ala Lys Pro 
            580                 585                 590         


Leu Arg Ala Ser Glu Pro Ser Lys Thr Pro Ser Ser Val Gln Glu Lys 
        595                 600                 605             


Lys Thr Arg Val Pro Thr Lys Ala Glu Pro Met Pro Lys Pro Pro Pro 
    610                 615                 620                 


Glu Thr Thr Pro Thr Pro Ala Thr Pro Lys Val Lys Ser Gly Val Arg 
625                 630                 635                 640 


Arg Ala Glu Pro Ala Thr Pro Val Val Lys Ala Val Pro Glu Ala Pro 
                645                 650                 655     


Lys Gly Gly Glu Ala Glu Asp Leu Val Gly Lys Pro Tyr Ser Gln Asp 
            660                 665                 670         


Ala Ser Arg Ser Pro Gln Ser Leu Ser Asp Thr Gly Tyr Ser Ser Asp 
        675                 680                 685             


Gly Ile Ser Ser Ser Gln Ser Glu Ile Thr Gly Val Val Gln Gln Glu 
    690                 695                 700                 


Val Glu Gln Leu Asp Ser Ala Gly Val Thr Gly Pro His Pro Pro Ser 
705                 710                 715                 720 


Pro Ser Glu Ile His Lys Val Gly Ser Ser Met Arg Pro Leu Leu Gln 
                725                 730                 735     


Ala Gln Gly Leu Ala Pro Ser Glu Arg Ser Lys Pro Leu Ser Ser Gly 
            740                 745                 750         


Thr Gly Glu Glu Gln Lys Gln Arg Pro His Ser Leu Ser Ile Thr Pro 
        755                 760                 765             


Glu Ala Phe Asp Ser Asp Glu Glu Leu Glu Asp Ile Leu Glu Glu Asp 
    770                 775                 780                 


Glu Asp Ser Ala Glu Trp Arg Arg Arg Arg Glu Gln Gln Asp Thr Ala 
785                 790                 795                 800 


Glu Ser Ser Asp Asp Phe Gly Ser Gln Leu Arg His Asp Tyr Val Glu 
                805                 810                 815     


Asp Ser Ser Glu Gly Gly Leu Ser Pro Leu Pro Pro Gln Pro Pro Ala 
            820                 825                 830         


Arg Ala Ala Glu Leu Thr Asp Glu Asp Phe Met Arg Arg Gln Ile Leu 
        835                 840                 845             


Glu Met Ser Ala Glu Glu Asp Asn Leu Glu Glu Asp Asp Thr Ala Thr 
    850                 855                 860                 


Ser Gly Arg Gly Leu Ala Lys His Gly Thr Gln Lys Gly Gly Pro Arg 
865                 870                 875                 880 


Pro Arg Pro Glu Pro Ser Gln Glu Pro Ala Ala Leu Pro Lys Arg Arg 
                885                 890                 895     


Leu Pro His Asn Ala Thr Thr Gly Tyr Glu Glu Leu Leu Pro Glu Gly 
            900                 905                 910         


Gly Ser Ala Glu Ala Thr Asp Gly Ser Gly Thr Leu Gln Gly Gly Leu 
        915                 920                 925             


Arg Arg Phe Lys Thr Ile Glu Leu Asn Ser Thr Gly Ser Tyr Gly His 
    930                 935                 940                 


Glu Leu Asp Leu Gly Gln Gly Pro Asp Pro Ser Leu Asp Arg Glu Pro 
945                 950                 955                 960 


Glu Leu Glu Met Glu Ser Leu Thr Gly Ser Pro Glu Asp Arg Ser Arg 
                965                 970                 975     


Gly Glu His Ser Ser Thr Leu Pro Ala Ser Thr Pro Ser Tyr Thr Ser 
            980                 985                 990         


Gly Thr Ser Pro Thr Ser Leu Ser  Ser Leu Glu Glu Asp  Ser Asp Ser 
        995                 1000                 1005             


Ser Pro  Ser Arg Arg Gln Arg  Leu Glu Glu Ala Lys  Gln Gln Arg 
    1010                 1015                 1020             


Lys Ala  Arg His Arg Ser His  Gly Pro Leu Leu Pro  Thr Ile Glu 
    1025                 1030                 1035             


Asp Ser  Ser Glu Glu Glu Glu  Leu Arg Glu Glu Glu  Glu Leu Leu 
    1040                 1045                 1050             


Arg Glu  Gln Glu Lys Met Arg  Glu Val Glu Gln Gln  Arg Ile Arg 
    1055                 1060                 1065             


Ser Thr  Ala Arg Lys Thr Arg  Arg Asp Lys Glu Glu  Leu Arg Ala 
    1070                 1075                 1080             


Gln Arg  Arg Arg Glu Arg Ser  Lys Thr Pro Pro Ser  Asn Leu Ser 
    1085                 1090                 1095             


Pro Ile  Glu Asp Ala Ser Pro  Thr Glu Glu Leu Arg  Gln Ala Ala 
    1100                 1105                 1110             


Glu Met  Glu Glu Leu His Arg  Ser Ser Cys Ser Glu  Tyr Ser Pro 
    1115                 1120                 1125             


Ser Pro  Ser Leu Asp Ser Glu  Ala Glu Ala Leu Asp  Gly Gly Pro 
    1130                 1135                 1140             


Ser Arg  Leu Tyr Lys Ser Gly  Ser Glu Tyr Asn Leu  Pro Thr Phe 
    1145                 1150                 1155             


Met Ser  Leu Tyr Ser Pro Thr  Glu Thr Pro Ser Gly  Ser Ser Thr 
    1160                 1165                 1170             


Thr Pro  Ser Ser Gly Arg Pro  Leu Lys Ser Ala Glu  Glu Ala Tyr 
    1175                 1180                 1185             


Glu Glu  Met Met Arg Lys Ala  Glu Leu Leu Gln Arg  Gln Gln Gly 
    1190                 1195                 1200             


Gln Ala  Ala Gly Ala Arg Gly  Pro His Gly Gly Pro  Ser Gln Pro 
    1205                 1210                 1215             


Thr Gly  Pro Arg Gly Leu Gly  Ser Phe Glu Tyr Gln  Asp Thr Thr 
    1220                 1225                 1230             


Asp Arg  Glu Tyr Gly Gln Ala  Ala Gln Pro Ala Ala  Glu Gly Thr 
    1235                 1240                 1245             


Pro Ala  Ser Leu Gly Ala Ala  Val Tyr Glu Glu Ile  Leu Gln Thr 
    1250                 1255                 1260             


Ser Gln  Ser Ile Val Arg Met  Arg Gln Ala Ser Ser  Arg Asp Leu 
    1265                 1270                 1275             


Ala Phe  Ala Glu Asp Lys Lys  Lys Glu Lys Gln Phe  Leu Asn Ala 
    1280                 1285                 1290             


Glu Ser  Ala Tyr Met Asp Pro  Met Lys Gln Asn Gly  Gly Pro Leu 
    1295                 1300                 1305             


Thr Pro  Gly Thr Ser Pro Thr  Gln Leu Ala Ala Pro  Val Ser Phe 
    1310                 1315                 1320             


Ser Thr  Pro Thr Ser Ser Asp  Ser Ser Gly Gly Arg  Val Ile Pro 
    1325                 1330                 1335             


Asp Val  Arg Val Thr Gln His  Phe Ala Lys Glu Thr  Gln Asp Pro 
    1340                 1345                 1350             


Leu Lys  Leu His Ser Ser Pro  Ala Ser Pro Ser Ser  Ala Ser Lys 
    1355                 1360                 1365             


Glu Ile  Gly Met Pro Phe Ser  Gln Gly Pro Gly Thr  Pro Ala Thr 
    1370                 1375                 1380             


Thr Ala  Val Ala Pro Cys Pro  Ala Gly Leu Pro Arg  Gly Tyr Met 
    1385                 1390                 1395             


Thr Pro  Ala Ser Pro Ala Gly  Ser Glu Arg Ser Pro  Ser Pro Ser 
    1400                 1405                 1410             


Ser Thr  Ala His Ser Tyr Gly  His Ser Pro Thr Thr  Ala Asn Tyr 
    1415                 1420                 1425             


Gly Ser  Gln Thr Glu Asp Leu  Pro Gln Ala Pro Ser  Gly Leu Ala 
    1430                 1435                 1440             


Ala Ala  Gly Arg Ala Ala Arg  Glu Lys Pro Leu Ser  Ala Ser Asp 
    1445                 1450                 1455             


Gly Glu  Gly Gly Thr Pro Gln  Pro Ser Arg Ala Tyr  Ser Tyr Phe 
    1460                 1465                 1470             


Ala Ser  Ser Ser Pro Pro Leu  Ser Pro Ser Ser Pro  Ser Glu Ser 
    1475                 1480                 1485             


Pro Thr  Phe Ser Pro Gly Lys  Met Gly Pro Arg Ala  Thr Ala Glu 
    1490                 1495                 1500             


Phe Ser  Thr Gln Thr Pro Ser  Pro Ala Pro Ala Ser  Asp Met Pro 
    1505                 1510                 1515             


Arg Ser  Pro Gly Ala Pro Thr  Pro Ser Pro Met Val  Ala Gln Gly 
    1520                 1525                 1530             


Thr Gln  Thr Pro His Arg Pro  Ser Thr Pro Arg Leu  Val Trp Gln 
    1535                 1540                 1545             


Glu Ser  Ser Gln Glu Ala Pro  Phe Met Val Ile Thr  Leu Ala Ser 
    1550                 1555                 1560             


Asp Ala  Ser Ser Gln Thr Arg  Met Val His Ala Ser  Ala Ser Thr 
    1565                 1570                 1575             


Ser Pro  Leu Cys Ser Pro Thr  Glu Thr Gln Pro Thr  Thr His Gly 
    1580                 1585                 1590             


Tyr Ser  Gln Thr Thr Pro Pro  Ser Val Ser Gln Leu  Pro Pro Glu 
    1595                 1600                 1605             


Pro Pro  Gly Pro Pro Gly Phe  Pro Arg Val Pro Ser  Ala Gly Ala 
    1610                 1615                 1620             


Asp Gly  Pro Leu Ala Leu Tyr  Gly Trp Gly Ala Leu  Pro Ala Glu 
    1625                 1630                 1635             


Asn Ile  Ser Leu Cys Arg Ile  Ser Ser Val Pro Gly  Thr Ser Arg 
    1640                 1645                 1650             


Val Glu  Pro Gly Pro Arg Thr  Pro Gly Thr Ala Val  Val Asp Leu 
    1655                 1660                 1665             


Arg Thr  Ala Val Lys Pro Thr  Pro Ile Ile Leu Thr  Asp Gln Gly 
    1670                 1675                 1680             


Met Asp  Leu Thr Ser Leu Ala  Val Glu Ala Arg Lys  Tyr Gly Leu 
    1685                 1690                 1695             


Ala Leu  Asp Pro Ile Pro Gly  Arg Gln Ser Thr Ala  Val Gln Pro 
    1700                 1705                 1710             


Leu Val  Ile Asn Leu Asn Ala  Gln Glu His Thr Phe  Leu Ala Thr 
    1715                 1720                 1725             


Ala Thr  Thr Val Ser Ile Thr  Met Ala Ser Ser Val  Phe Met Ala 
    1730                 1735                 1740             


Gln Gln  Lys Gln Pro Val Val  Tyr Gly Asp Pro Tyr  Gln Ser Arg 
    1745                 1750                 1755             


Leu Asp  Phe Gly Gln Gly Gly  Gly Ser Pro Val Cys  Leu Ala Gln 
    1760                 1765                 1770             


Val Lys  Gln Val Glu Gln Ala  Val Gln Thr Ala Pro  Tyr Arg Ser 
    1775                 1780                 1785             


Gly Pro  Arg Gly Arg Pro Arg  Glu Ala Lys Phe Ala  Arg Tyr Asn 
    1790                 1795                 1800             


Leu Pro  Asn Gln Val Ala Pro  Leu Ala Arg Arg Asp  Val Leu Ile 
    1805                 1810                 1815             


Thr Gln  Met Gly Thr Ala Gln  Ser Ile Gly Leu Lys  Pro Gly Pro 
    1820                 1825                 1830             


Val Pro  Glu Pro Gly Ala Glu  Pro His Arg Ala Thr  Pro Ala Glu 
    1835                 1840                 1845             


Leu Arg  Ser His Ala Leu Pro  Gly Ala Arg Lys Pro  His Thr Val 
    1850                 1855                 1860             


Val Val  Gln Met Gly Glu Gly  Thr Ala Gly Thr Val  Thr Thr Leu 
    1865                 1870                 1875             


Leu Pro  Glu Glu Pro Ala Gly  Ala Leu Asp Leu Thr  Gly Met Arg 
    1880                 1885                 1890             


Pro Glu  Ser Gln Leu Ala Cys  Cys Asp Met Val Tyr  Lys Leu Pro 
    1895                 1900                 1905             


Phe Gly  Ser Ser Cys Thr Gly  Thr Phe His Pro Ala  Pro Ser Val 
    1910                 1915                 1920             


Pro Glu  Lys Ser Met Ala Asp  Ala Ala Pro Pro Gly  Gln Ser Ser 
    1925                 1930                 1935             


Ser Pro  Phe Tyr Gly Pro Arg  Asp Pro Glu Pro Pro  Glu Pro Pro 
    1940                 1945                 1950             


Thr Tyr  Arg Ala Gln Gly Val  Val Gly Pro Gly Pro  His Glu Glu 
    1955                 1960                 1965             


Gln Arg  Pro Tyr Pro Gln Gly  Leu Pro Gly Arg Leu  Tyr Ser Ser 
    1970                 1975                 1980             


Met Ser  Asp Thr Asn Leu Ala  Glu Ala Gly Leu Asn  Tyr His Ala 
    1985                 1990                 1995             


Gln Arg  Ile Gly Gln Leu Phe  Gln Gly Pro Gly Arg  Asp Ser Ala 
    2000                 2005                 2010             


Met Asp  Leu Ser Ser Leu Lys  His Ser Tyr Ser Leu  Gly Phe Ala 
    2015                 2020                 2025             


Asp Gly  Arg Tyr Leu Gly Gln  Gly Leu Gln Tyr Gly  Ser Val Thr 
    2030                 2035                 2040             


Asp Leu  Arg His Pro Thr Asp  Leu Leu Ala His Pro  Leu Pro Met 
    2045                 2050                 2055             


Arg Arg  Tyr Ser Ser Val Ser  Asn Ile Tyr Ser Asp  His Arg Tyr 
    2060                 2065                 2070             


Gly Pro  Arg Gly Asp Ala Val  Gly Phe Gln Glu Ala  Ser Leu Ala 
    2075                 2080                 2085             


Gln Tyr  Ser Ala Thr Thr Ala  Arg Glu Ile Ser Arg  Met Cys Ala 
    2090                 2095                 2100             


Ala Leu  Asn Ser Met Asp Gln  Tyr Gly Gly Arg His  Gly Ser Gly 
    2105                 2110                 2115             


Gly Gly  Gly Pro Asp Leu Val  Gln Tyr Gln Pro Gln  His Gly Pro 
    2120                 2125                 2130             


Gly Leu  Ser Ala Pro Gln Ser  Leu Val Pro Leu Arg  Pro Gly Leu 
    2135                 2140                 2145             


Leu Gly  Asn Pro Thr Phe Pro  Glu Gly His Pro Ser  Pro Gly Asn 
    2150                 2155                 2160             


Leu Ala  Gln Tyr Gly Pro Ala  Ala Gly Gln Gly Thr  Ala Val Arg 
    2165                 2170                 2175             


Gln Leu  Leu Pro Ser Thr Ala  Thr Val Arg Ala Ala  Asp Gly Met 
    2180                 2185                 2190             


Ile Tyr  Ser Thr Ile Asn Thr  Pro Ile Ala Ala Thr  Leu Pro Ile 
    2195                 2200                 2205             


Thr Thr  Gln Pro Ala Ser Val  Leu Arg Pro Met Val  Arg Gly Gly 
    2210                 2215                 2220             


Met Tyr  Arg Pro Tyr Ala Ser  Gly Gly Ile Thr Ala  Val Pro Leu 
    2225                 2230                 2235             


Thr Ser  Leu Thr Arg Val Pro  Met Ile Ala Pro Arg  Val Pro Leu 
    2240                 2245                 2250             


Gly Pro  Thr Gly Leu Tyr Arg  Tyr Pro Ala Pro Ser  Arg Phe Pro 
    2255                 2260                 2265             


Ile Ala  Ser Ser Val Pro Pro  Ala Glu Gly Pro Val  Tyr Leu Gly 
    2270                 2275                 2280             


Lys Pro  Ala Ala Ala Lys Ala  Pro Gly Ala Gly Gly  Pro Ser Arg 
    2285                 2290                 2295             


Pro Glu  Met Pro Val Gly Ala  Ala Arg Glu Glu Pro  Leu Pro Thr 
    2300                 2305                 2310             


Thr Thr  Pro Ala Ala Ile Lys  Glu Ala Ala Gly Ala  Pro Ala Pro 
    2315                 2320                 2325             


Ala Pro  Leu Ala Gly Gln Lys  Pro Pro Ala Asp Ala  Ala Pro Gly 
    2330                 2335                 2340             


Gly Gly  Ser Gly Ala Leu Ser  Arg Pro Gly Phe Glu  Lys Glu Glu 
    2345                 2350                 2355             


Ala Ser  Gln Glu Glu Arg Gln  Arg Lys Gln Gln Glu  Gln Leu Leu 
    2360                 2365                 2370             


Gln Leu  Glu Arg Glu Arg Val  Glu Leu Glu Lys Leu  Arg Gln Leu 
    2375                 2380                 2385             


Arg Leu  Gln Glu Glu Leu Glu  Arg Glu Arg Val Glu  Leu Gln Arg 
    2390                 2395                 2400             


His Arg  Glu Glu Glu Gln Leu  Leu Val Gln Arg Glu  Leu Gln Glu 
    2405                 2410                 2415             


Leu Gln  Thr Ile Lys His His  Val Leu Gln Gln Gln  Gln Glu Glu 
    2420                 2425                 2430             


Arg Gln  Ala Gln Phe Ala Leu  Gln Arg Glu Gln Leu  Ala Gln Gln 
    2435                 2440                 2445             


Arg Leu  Gln Leu Glu Gln Ile  Gln Gln Leu Gln Gln  Gln Leu Gln 
    2450                 2455                 2460             


Gln Gln  Leu Glu Glu Gln Lys  Gln Arg Gln Lys Ala  Pro Phe Pro 
    2465                 2470                 2475             


Ala Ala  Cys Glu Ala Pro Gly  Arg Gly Pro Pro Leu  Ala Ala Ala 
    2480                 2485                 2490             


Glu Leu  Ala Gln Asn Gly Gln  Tyr Trp Pro Pro Leu  Thr His Ala 
    2495                 2500                 2505             


Ala Phe  Ile Ala Met Ala Gly  Pro Glu Gly Leu Gly  Gln Pro Arg 
    2510                 2515                 2520             


Glu Pro  Val Leu His Arg Gly  Leu Pro Ser Ser Ala  Ser Asp Met 
    2525                 2530                 2535             


Ser Leu  Gln Thr Glu Glu Gln  Trp Glu Ala Ser Arg  Ser Gly Ile 
    2540                 2545                 2550             


Lys Lys  Arg His Ser Met Pro  Arg Leu Arg Asp Ala  Cys Glu Leu 
    2555                 2560                 2565             


Glu Ser  Gly Thr Glu Pro Cys  Val Val Arg Arg Ile  Ala Asp Ser 
    2570                 2575                 2580             


Ser Val  Gln Thr Asp Asp Glu  Asp Gly Glu Ser Arg  Tyr Leu Leu 
    2585                 2590                 2595             


Ser Arg  Arg Arg Arg Ala Arg  Arg Ser Ala Asp Cys  Ser Val Gln 
    2600                 2605                 2610             


Thr Asp  Asp Glu Asp Ser Ala  Glu Trp Glu Gln Pro  Val Arg Arg 
    2615                 2620                 2625             


Arg Arg  Ser Arg Leu Pro Arg  His Ser Asp Ser Gly  Ser Asp Ser 
    2630                 2635                 2640             


Lys His  Asp Ala Thr Ala Ser  Ser Ser Ser Ala Ala  Ala Thr Val 
    2645                 2650                 2655             


Arg Ala  Met Ser Ser Val Gly  Ile Gln Thr Ile Ser  Asp Cys Ser 
    2660                 2665                 2670             


Val Gln  Thr Glu Pro Asp Gln  Leu Pro Arg Val Ser  Pro Ala Ile 
    2675                 2680                 2685             


His Ile  Thr Ala Ala Thr Asp  Pro Lys Val Glu Ile  Val Arg Tyr 
    2690                 2695                 2700             


Ile Ser  Ala Pro Glu Lys Thr  Gly Arg Gly Glu Ser  Leu Ala Cys 
    2705                 2710                 2715             


Gln Thr  Glu Pro Asp Gly Gln  Ala Gln Gly Val Ala  Gly Pro Gln 
    2720                 2725                 2730             


Leu Val  Gly Pro Thr Ala Ile  Ser Pro Tyr Leu Pro  Gly Ile Gln 
    2735                 2740                 2745             


Ile Val  Thr Pro Gly Pro Leu  Gly Arg Phe Glu Lys  Lys Lys Pro 
    2750                 2755                 2760             


Asp Pro  Leu Glu Ile Gly Tyr  Gln Ala His Leu Pro  Pro Glu Ser 
    2765                 2770                 2775             


Leu Ser  Gln Leu Val Ser Arg  Gln Pro Pro Lys Ser  Pro Gln Val 
    2780                 2785                 2790             


Leu Tyr  Ser Pro Val Ser Pro  Leu Ser Pro His Arg  Leu Leu Asp 
    2795                 2800                 2805             


Thr Ser  Phe Ala Ser Ser Glu  Arg Leu Asn Lys Ala  His Val Ser 
    2810                 2815                 2820             


Pro Gln  Lys His Phe Thr Ala  Asp Ser Ala Leu Arg  Gln Gln Thr 
    2825                 2830                 2835             


Leu Pro  Arg Pro Met Lys Thr  Leu Gln Arg Ser Leu  Ser Asp Pro 
    2840                 2845                 2850             


Lys Pro  Leu Ser Pro Thr Ala  Glu Glu Ser Ala Lys  Glu Arg Phe 
    2855                 2860                 2865             


Ser Leu  Tyr Gln His Gln Gly  Gly Leu Gly Ser Gln  Val Ser Ala 
    2870                 2875                 2880             


Leu Pro  Pro Asn Ser Leu Val  Arg Lys Val Lys Arg  Thr Leu Pro 
    2885                 2890                 2895             


Ser Pro  Pro Pro Glu Glu Ala  His Leu Pro Leu Ala  Gly Gln Ala 
    2900                 2905                 2910             


Ser Pro  Gln Leu Tyr Ala Ala  Ser Leu Leu Gln Arg  Gly Leu Thr 
    2915                 2920                 2925             


Gly Pro  Thr Thr Val Pro Ala  Thr Lys Ala Ser Leu  Leu Arg Glu 
    2930                 2935                 2940             


Leu Asp  Arg Asp Leu Arg Leu  Val Glu His Glu Ser  Thr Lys Leu 
    2945                 2950                 2955             


Arg Lys  Lys Gln Ala Glu Leu  Asp Glu Glu Glu Lys  Glu Ile Asp 
    2960                 2965                 2970             


Ala Lys  Leu Lys Tyr Leu Glu  Leu Gly Ile Thr Gln  Arg Lys Glu 
    2975                 2980                 2985             


Ser Leu  Ala Lys Asp Arg Gly  Gly Arg Asp Tyr Pro  Pro Leu Arg 
    2990                 2995                 3000             


Gly Leu  Gly Glu His Arg Asp  Tyr Leu Ser Asp Ser  Glu Leu Asn 
    3005                 3010                 3015             


Gln Leu  Arg Leu Gln Gly Cys  Thr Thr Pro Ala Gly  Gln Phe Val 
    3020                 3025                 3030             


Asp Phe  Pro Ala Thr Ala Ala  Ala Pro Ala Thr Pro  Ser Gly Pro 
    3035                 3040                 3045             


Thr Ala  Phe Gln Gln Pro Arg  Phe Gln Pro Pro Ala  Pro Gln Tyr 
    3050                 3055                 3060             


Ser Ala  Gly Ser Gly Gly Pro  Thr Gln Asn Gly Phe  Pro Ala His 
    3065                 3070                 3075             


Gln Ala  Pro Thr Tyr Pro Gly  Pro Ser Thr Tyr Pro  Ala Pro Ala 
    3080                 3085                 3090             


Phe Pro  Pro Gly Ala Ser Tyr  Pro Ala Glu Pro Gly  Leu Pro Asn 
    3095                 3100                 3105             


Gln Gln  Ala Phe Arg Pro Thr  Gly His Tyr Ala Gly  Gln Thr Pro 
    3110                 3115                 3120             


Met Pro  Thr Thr Gln Ser Thr  Leu Phe Pro Val Pro  Ala Asp Ser 
    3125                 3130                 3135             


Arg Ala  Pro Leu Gln Lys Pro  Arg Gln Thr Ser Leu  Ala Asp Leu 
    3140                 3145                 3150             


Glu Gln  Lys Val Pro Thr Asn  Tyr Glu Val Ile Ala  Ser Pro Val 
    3155                 3160                 3165             


Val Pro  Met Ser Ser Ala Pro  Ser Glu Thr Ser Tyr  Ser Gly Pro 
    3170                 3175                 3180             


Ala Val  Ser Ser Gly Tyr Glu  Gln Gly Lys Val Pro  Glu Val Pro 
    3185                 3190                 3195             


Arg Ala  Gly Asp Arg Gly Ser  Val Ser Gln Ser Pro  Ala Pro Thr 
    3200                 3205                 3210             


Tyr Pro  Ser Asp Ser His Tyr  Thr Ser Leu Glu Gln  Asn Val Pro 
    3215                 3220                 3225             


Arg Asn  Tyr Val Met Ile Asp  Asp Ile Ser Glu Leu  Thr Lys Asp 
    3230                 3235                 3240             


Ser Thr  Ser Thr Ala Pro Asp  Ser Gln Arg Leu Glu  Pro Leu Gly 
    3245                 3250                 3255             


Pro Gly  Ser Ser Gly Arg Pro  Gly Lys Glu Pro Gly  Glu Pro Gly 
    3260                 3265                 3270             


Val Leu  Asp Gly Pro Thr Leu  Pro Cys Cys Tyr Ala  Arg Gly Glu 
    3275                 3280                 3285             


Glu Glu  Ser Glu Glu Asp Ser  Tyr Asp Pro Arg Gly  Lys Gly Gly 
    3290                 3295                 3300             


His Leu  Arg Ser Met Glu Ser  Asn Gly Arg Pro Ala  Ser Thr His 
    3305                 3310                 3315             


Tyr Tyr  Gly Asp Ser Asp Tyr  Arg His Gly Ala Arg  Val Glu Lys 
    3320                 3325                 3330             


Tyr Gly  Pro Gly Pro Met Gly  Pro Lys His Pro Ser  Lys Ser Leu 
    3335                 3340                 3345             


Ala Pro  Ala Ala Ile Ser Ser  Lys Arg Ser Lys His  Arg Lys Gln 
    3350                 3355                 3360             


Gly Met  Glu Gln Lys Ile Ser  Lys Phe Ser Pro Ile  Glu Glu Ala 
    3365                 3370                 3375             


Lys Asp  Val Glu Ser Asp Leu  Ala Ser Tyr Pro Pro  Pro Ala Val 
    3380                 3385                 3390             


Ser Ser  Ser Leu Val Ser Arg  Gly Arg Lys Phe Gln  Asp Glu Ile 
    3395                 3400                 3405             


Thr Tyr  Gly Leu Lys Lys Asn  Val Tyr Glu Gln Gln  Lys Tyr Tyr 
    3410                 3415                 3420             


Gly Met  Ser Ser Arg Asp Ala  Val Glu Asp Asp Arg  Ile Tyr Gly 
    3425                 3430                 3435             


Gly Ser  Ser Arg Ser Arg Ala  Pro Ser Ala Tyr Ser  Gly Glu Lys 
    3440                 3445                 3450             


Leu Ser  Ser His Asp Phe Ser  Gly Trp Gly Lys Gly  Tyr Glu Arg 
    3455                 3460                 3465             


Glu Arg  Glu Ala Val Glu Arg  Leu Gln Lys Ala Gly  Pro Lys Pro 
    3470                 3475                 3480             


Ser Ser  Leu Ser Met Ala His  Ser Arg Val Arg Pro  Pro Met Arg 
    3485                 3490                 3495             


Ser Gln  Ala Ser Glu Glu Glu  Ser Pro Val Ser Pro  Leu Gly Arg 
    3500                 3505                 3510             


Pro Arg  Pro Ala Gly Gly Pro  Leu Pro Pro Gly Gly  Asp Thr Cys 
    3515                 3520                 3525             


Pro Gln  Phe Cys Ser Ser His  Ser Met Pro Asp Val  Gln Glu His 
    3530                 3535                 3540             


Val Lys  Asp Gly Pro Arg Ala  His Ala Tyr Lys Arg  Glu Glu Gly 
    3545                 3550                 3555             


Tyr Ile  Leu Asp Asp Ser His  Cys Val Val Ser Asp  Ser Glu Ala 
    3560                 3565                 3570             


Tyr His  Leu Gly Gln Glu Glu  Thr Asp Trp Phe Asp  Lys Pro Arg 
    3575                 3580                 3585             


Asp Ala  Arg Ser Asp Arg Phe  Arg His His Gly Gly  His Ala Val 
    3590                 3595                 3600             


Ser Ser  Ser Ser Gln Lys Arg  Gly Pro Ala Arg His  Ser Tyr His 
    3605                 3610                 3615             


Asp Tyr  Asp Glu Pro Pro Glu  Glu Gly Leu Trp Pro  His Asp Glu 
    3620                 3625                 3630             


Gly Gly  Pro Gly Arg His Ala  Ser Ala Lys Glu His  Arg His Gly 
    3635                 3640                 3645             


Asp His  Gly Arg His Ser Gly  Arg His Thr Gly Glu  Glu Pro Gly 
    3650                 3655                 3660             


Arg Arg  Ala Ala Lys Pro His  Ala Arg Asp Leu Gly  Arg His Glu 
    3665                 3670                 3675             


Ala Arg  Pro His Ser Gln Pro  Ser Ser Ala Pro Ala  Met Pro Lys 
    3680                 3685                 3690             


Lys Gly  Gln Pro Gly Tyr Pro  Ser Ser Ala Glu Tyr  Ser Gln Pro 
    3695                 3700                 3705             


Ser Arg  Ala Ser Ser Ala Tyr  His His Ala Ser Asp  Ser Lys Lys 
    3710                 3715                 3720             


Gly Ser  Arg Gln Ala His Ser  Gly Pro Ala Ala Leu  Gln Ser Lys 
    3725                 3730                 3735             


Ala Glu  Pro Gln Ala Gln Pro  Gln Leu Gln Gly Arg  Gln Ala Ala 
    3740                 3745                 3750             


Pro Gly  Pro Gln Gln Ser Gln  Ser Pro Ser Ser Arg  Gln Ile Pro 
    3755                 3760                 3765             


Ser Gly  Ala Ala Ser Arg Gln  Pro Gln Thr Gln Gln  Gln Gln Gln 
    3770                 3775                 3780             


Gly Leu  Gly Leu Gln Pro Pro  Gln Gln Ala Leu Thr  Gln Ala Arg 
    3785                 3790                 3795             


Leu Gln  Gln Gln Ser Gln Pro  Thr Thr Arg Gly Ser  Ala Pro Ala 
    3800                 3805                 3810             


Ala Ser  Gln Pro Ala Gly Lys  Pro Gln Pro Gly Pro  Ser Thr Ala 
    3815                 3820                 3825             


Thr Gly  Pro Gln Pro Ala Gly  Pro Pro Arg Ala Glu  Gln Thr Asn 
    3830                 3835                 3840             


Gly Ser  Lys Gly Thr Ala Lys  Ala Pro Gln Gln Gly  Arg Ala Pro 
    3845                 3850                 3855             


Gln Ala  Gln Pro Ala Pro Gly  Pro Gly Pro Ala Gly  Val Lys Ala 
    3860                 3865                 3870             


Gly Ala  Arg Pro Gly Gly Thr  Pro Gly Ala Pro Ala  Gly Gln Pro 
    3875                 3880                 3885             


Gly Ala  Asp Gly Glu Ser Val  Phe Ser Lys Ile Leu  Pro Gly Gly 
    3890                 3895                 3900             


Ala Ala  Glu Gln Ala Gly Lys  Leu Thr Glu Ala Val  Ser Ala Phe 
    3905                 3910                 3915             


Gly Lys  Lys Phe Ser Ser Phe  Trp 
    3920                 3925     


<210>  1256
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSPH1__Homo_sapiens__NP_001121798

<400>  1256

Met Gly Ser Leu Met Leu Leu Phe Val Glu Thr Thr Arg Asn Ser Ser 
1               5                   10                  15      


Ala Cys Ile Phe Pro Val Ile Leu Asn Glu Leu Ser Ser Thr Val Glu 
            20                  25                  30          


Thr Ile Thr His Phe Pro Glu Val Thr Asp Gly Glu Cys Val Phe Pro 
        35                  40                  45              


Phe His Tyr Lys Asn Gly Thr Tyr Tyr Asp Cys Ile Lys Ser Lys Ala 
    50                  55                  60                  


Arg His Lys Trp Cys Ser Leu Asn Lys Thr Tyr Glu Gly Tyr Trp Lys 
65                  70                  75                  80  


Phe Cys Ser Ala Glu Asp Phe Ala Asn Cys Val Phe Pro Phe Trp Tyr 
                85                  90                  95      


Arg Arg Leu Ile Tyr Trp Glu Cys Thr Asp Asp Gly Glu Ala Phe Gly 
            100                 105                 110         


Lys Lys Trp Cys Ser Leu Thr Lys Asn Phe Asn Lys Asp Arg Ile Trp 
        115                 120                 125             


Lys Tyr Cys Glu 
    130         


<210>  1257
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSPRY__Homo_sapiens__NP_060158

<400>  1257

Met Ser Ala Glu Gly Ala Glu Pro Gly Pro Gly Ser Gly Ser Gly Pro 
1               5                   10                  15      


Gly Pro Gly Pro Leu Cys Pro Glu His Gly Gln Ala Leu Ser Trp Phe 
            20                  25                  30          


Cys Gly Ser Glu Arg Arg Pro Val Cys Ala Ala Cys Ala Gly Leu Gly 
        35                  40                  45              


Gly Arg Cys Arg Gly His Arg Ile Arg Arg Ala Glu Glu Arg Ala Glu 
    50                  55                  60                  


Glu Leu Arg Asn Lys Ile Val Asp Gln Cys Glu Arg Leu Gln Leu Gln 
65                  70                  75                  80  


Ser Ala Ala Ile Thr Lys Tyr Val Ala Asp Val Leu Pro Gly Lys Asn 
                85                  90                  95      


Gln Arg Ala Val Ser Met Ala Ser Ala Ala Arg Glu Leu Val Ile Gln 
            100                 105                 110         


Arg Leu Ser Leu Val Arg Ser Leu Cys Glu Ser Glu Glu Gln Arg Leu 
        115                 120                 125             


Leu Glu Gln Val His Gly Glu Glu Glu Arg Ala His Gln Ser Ile Leu 
    130                 135                 140                 


Thr Gln Arg Val His Trp Ala Glu Ala Leu Gln Lys Leu Asp Thr Ile 
145                 150                 155                 160 


Arg Thr Gly Leu Val Gly Met Leu Thr His Leu Asp Asp Leu Gln Leu 
                165                 170                 175     


Ile Gln Lys Glu Gln Glu Ile Phe Glu Arg Thr Glu Glu Ala Glu Gly 
            180                 185                 190         


Ile Leu Asp Pro Gln Glu Ser Glu Met Leu Asn Phe Asn Glu Lys Cys 
        195                 200                 205             


Thr Arg Ser Pro Leu Leu Thr Gln Leu Trp Ala Thr Ala Val Leu Gly 
    210                 215                 220                 


Ser Leu Ser Gly Thr Glu Asp Ile Arg Ile Asp Glu Arg Thr Val Ser 
225                 230                 235                 240 


Pro Phe Leu Gln Leu Ser Asp Asp Arg Lys Thr Leu Thr Phe Ser Thr 
                245                 250                 255     


Lys Lys Ser Lys Ala Cys Ala Asp Gly Pro Glu Arg Phe Asp His Trp 
            260                 265                 270         


Pro Asn Ala Leu Ala Ala Thr Ser Phe Gln Asn Gly Leu His Ala Trp 
        275                 280                 285             


Met Val Asn Val Gln Asn Ser Cys Ala Tyr Lys Val Gly Val Ala Ser 
    290                 295                 300                 


Gly His Leu Pro Arg Lys Gly Ser Gly Ser Asp Cys Arg Leu Gly His 
305                 310                 315                 320 


Asn Ala Phe Ser Trp Val Phe Ser Arg Tyr Asp Gln Glu Phe Arg Phe 
                325                 330                 335     


Ser His Asn Gly Gln His Glu Pro Leu Gly Leu Leu Arg Gly Pro Ala 
            340                 345                 350         


Gln Leu Gly Val Val Leu Asp Leu Gln Val Gln Glu Leu Leu Phe Tyr 
        355                 360                 365             


Glu Pro Ala Ser Gly Thr Val Leu Cys Ala His His Val Ser Phe Pro 
    370                 375                 380                 


Gly Pro Leu Phe Pro Val Phe Ala Val Ala Asp Gln Thr Ile Ser Ile 
385                 390                 395                 400 


Val Arg 
        


<210>  1258
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BST1__Homo_sapiens__NP_004325

<400>  1258

Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn 
    50                  55                  60                  


Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys 
65                  70                  75                  80  


Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu 
                85                  90                  95      


Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser 
            100                 105                 110         


His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro 
        115                 120                 125             


Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys 
    130                 135                 140                 


Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser 
145                 150                 155                 160 


Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser 
                165                 170                 175     


Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn 
            180                 185                 190         


Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
        195                 200                 205             


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
    210                 215                 220                 


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
225                 230                 235                 240 


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
                245                 250                 255     


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
            260                 265                 270         


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala 
        275                 280                 285             


Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu 
    290                 295                 300                 


Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
305                 310                 315             


<210>  1259
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BST2__Homo_sapiens__NP_004326

<400>  1259

Met Ala Ser Thr Ser Tyr Asp Tyr Cys Arg Val Pro Met Glu Asp Gly 
1               5                   10                  15      


Asp Lys Arg Cys Lys Leu Leu Leu Gly Ile Gly Ile Leu Val Leu Leu 
            20                  25                  30          


Ile Ile Val Ile Leu Gly Val Pro Leu Ile Ile Phe Thr Ile Lys Ala 
        35                  40                  45              


Asn Ser Glu Ala Cys Arg Asp Gly Leu Arg Ala Val Met Glu Cys Arg 
    50                  55                  60                  


Asn Val Thr His Leu Leu Gln Gln Glu Leu Thr Glu Ala Gln Lys Gly 
65                  70                  75                  80  


Phe Gln Asp Val Glu Ala Gln Ala Ala Thr Cys Asn His Thr Val Met 
                85                  90                  95      


Ala Leu Met Ala Ser Leu Asp Ala Glu Lys Ala Gln Gly Gln Lys Lys 
            100                 105                 110         


Val Glu Glu Leu Glu Gly Glu Ile Thr Thr Leu Asn His Lys Leu Gln 
        115                 120                 125             


Asp Ala Ser Ala Glu Val Glu Arg Leu Arg Arg Glu Asn Gln Val Leu 
    130                 135                 140                 


Ser Val Arg Ile Ala Asp Lys Lys Tyr Tyr Pro Ser Ser Gln Asp Ser 
145                 150                 155                 160 


Ser Ser Ala Ala Ala Pro Gln Leu Leu Ile Val Leu Leu Gly Leu Ser 
                165                 170                 175     


Ala Leu Leu Gln 
            180 


<210>  1260
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSX__Homo_sapiens__NP_001091639

<400>  1260

Met Asn Leu Asn Phe Thr Ser Pro Leu His Pro Ala Ser Ser Gln Arg 
1               5                   10                  15      


Pro Thr Ser Phe Phe Ile Glu Asp Ile Leu Leu His Lys Pro Lys Pro 
            20                  25                  30          


Leu Arg Glu Val Ala Pro Asp His Phe Ala Ser Ser Leu Ala Ser Arg 
        35                  40                  45              


Val Pro Leu Leu Asp Tyr Gly Tyr Pro Leu Met Pro Thr Pro Thr Leu 
    50                  55                  60                  


Leu Ala Pro His Ala His His Pro Leu His Lys Gly Asp His His His 
65                  70                  75                  80  


Pro Tyr Phe Leu Thr Thr Ser Gly Met Pro Val Pro Ala Leu Phe Pro 
                85                  90                  95      


His Pro Gln His Ala Glu Leu Pro Gly Lys His Cys Arg Arg Arg Lys 
            100                 105                 110         


Ala Arg Thr Val Phe Ser Asp Ser Gln Leu Ser Gly Leu Glu Lys Arg 
        115                 120                 125             


Phe Glu Ile Gln Arg Tyr Leu Ser Thr Pro Glu Arg Val Glu Leu Ala 
    130                 135                 140                 


Thr Ala Leu Ser Leu Ser Glu Thr Gln Val Lys Thr Trp Phe Gln Asn 
145                 150                 155                 160 


Arg Arg Met Lys His Lys Lys Gln Leu Arg Lys Ser Gln Asp Glu Pro 
                165                 170                 175     


Lys Ala Pro Asp Gly Pro Glu Ser Pro Glu Gly Ser Pro Arg Gly Ser 
            180                 185                 190         


Glu Ala Ala Thr Ala Ala Glu Ala Arg Leu Ser Leu Pro Ala Gly Pro 
        195                 200                 205             


Phe Val Leu Thr Glu Pro Glu Asp Glu Val Asp Ile Gly Asp Glu Gly 
    210                 215                 220                 


Glu Leu Gly Ser Gly Pro His Val Leu 
225                 230             


<210>  1261
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD10__Homo_sapiens__XP_011518706

<400>  1261

Met Ala Gly Arg Pro His Pro Tyr Asp Gly Asn Ser Ser Asp Pro Glu 
1               5                   10                  15      


Asn Trp Asp Arg Lys Leu His Ser Arg Pro Arg Lys Leu Tyr Lys His 
            20                  25                  30          


Ser Ser Thr Ser Ser Arg Ile Ala Lys Gly Gly Val Asp His Thr Lys 
        35                  40                  45              


Met Ser Leu His Gly Ala Ser Gly Gly His Glu Arg Ser Arg Asp Arg 
    50                  55                  60                  


Arg Arg Ser Ser Asp Arg Ser Arg Asp Ser Ser His Glu Arg Thr Glu 
65                  70                  75                  80  


Ser Gln Leu Thr Pro Cys Ile Arg Asn Val Thr Ser Pro Thr Arg Gln 
                85                  90                  95      


His His Val Glu Arg Glu Lys Asp His Ser Ser Ser Arg Pro Ser Ser 
            100                 105                 110         


Pro Arg Pro Gln Lys Ala Ser Pro Asn Gly Ser Ile Ser Ser Ala Gly 
        115                 120                 125             


Asn Ser Ser Arg Asn Ser Ser Gln Ser Ser Ser Asp Gly Ser Cys Lys 
    130                 135                 140                 


Thr Ala Gly Glu Met Val Phe Val Tyr Glu Asn Ala Lys Glu Gly Ala 
145                 150                 155                 160 


Arg Asn Ile Arg Thr Ser Glu Arg Val Thr Leu Ile Val Asp Asn Thr 
                165                 170                 175     


Arg Phe Val Val Asp Pro Ser Ile Phe Thr Ala Gln Pro Asn Thr Met 
            180                 185                 190         


Leu Gly Arg Met Phe Gly Ser Gly Arg Glu His Asn Phe Thr Arg Pro 
        195                 200                 205             


Asn Glu Lys Gly Glu Tyr Glu Val Ala Glu Gly Ile Gly Ser Thr Val 
    210                 215                 220                 


Phe Arg Ala Ile Leu Asp Tyr Tyr Lys Thr Gly Ile Ile Arg Cys Pro 
225                 230                 235                 240 


Asp Gly Ile Ser Ile Pro Glu Leu Arg Glu Ala Cys Asp Tyr Leu Cys 
                245                 250                 255     


Ile Ser Phe Glu Tyr Ser Thr Ile Lys Cys Arg Asp Leu Ser Ala Leu 
            260                 265                 270         


Met His Glu Leu Ser Asn Asp Gly Ala Arg Arg Gln Phe Glu Phe Tyr 
        275                 280                 285             


Leu Glu Glu Met Ile Leu Pro Leu Met Val Ala Ser Ala Gln Ser Gly 
    290                 295                 300                 


Glu Arg Glu Cys His Ile Val Val Leu Thr Asp Asp Asp Val Val Asp 
305                 310                 315                 320 


Trp Asp Glu Glu Tyr Pro Pro Gln Met Gly Glu Glu Tyr Ser Gln Ile 
                325                 330                 335     


Ile Tyr Ser Thr Lys Leu Tyr Arg Phe Phe Lys Tyr Ile Glu Asn Arg 
            340                 345                 350         


Asp Val Ala Lys Ser Val Leu Lys Glu Arg Gly Leu Lys Lys Ile Arg 
        355                 360                 365             


Leu Gly Ile Glu Gly Tyr Pro Thr Tyr Lys Glu Lys Val Lys Lys Arg 
    370                 375                 380                 


Pro Gly Gly Arg Pro Glu Val Ile Tyr Asn Tyr Val Gln Arg Pro Phe 
385                 390                 395                 400 


Ile Arg Met Ser Trp Glu Lys Glu Glu Gly Lys Ser Arg His Val Asp 
                405                 410                 415     


Phe Gln Cys Val Lys Ser Lys Ser Ile Thr Asn Leu Ala Ala Ala Ala 
            420                 425                 430         


Ala Asp Ile Pro Gln Asp Gln Leu Val Val Met His Pro Thr Pro Gln 
        435                 440                 445             


Val Asp Glu Leu Asp Ile Leu Pro Ile His Pro Pro Ser Gly Asn Ser 
    450                 455                 460                 


Asp Leu Asp Pro Asp Ala Gln Asn Pro Met Leu 
465                 470                 475 


<210>  1262
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD11__Homo_sapiens__NP_001017523

<400>  1262

Met Arg Lys Leu Arg Pro Lys Asp Ser Arg Glu Pro Ala Pro Gly Ser 
1               5                   10                  15      


Pro Val Arg Ser Gly Cys Leu Gln Arg Leu Ser His Tyr Ser Gly Ile 
            20                  25                  30          


Gln Arg Pro Phe Leu Val Leu Pro Pro Leu Met Glu Trp Ile Arg Val 
        35                  40                  45              


Ala Val Ala His Ala Gly His Arg Arg Ser Phe Ser Met Asp Ser Asp 
    50                  55                  60                  


Asp Val Arg Gln Ala Ala Arg Leu Leu Leu Pro Gly Val Asp Cys Glu 
65                  70                  75                  80  


Pro Arg Gln Leu Arg Ala Asp Asp Cys Phe Cys Ala Ser Arg Lys Leu 
                85                  90                  95      


Asp Ala Val Ala Ile Glu Ala Lys Phe Lys Gln Asp Leu Gly Phe Arg 
            100                 105                 110         


Met Leu Asn Cys Gly Arg Thr Asp Leu Val Lys Gln Ala Val Ser Leu 
        115                 120                 125             


Leu Gly Pro Asp Gly Ile Asn Thr Met Ser Glu Gln Gly Met Thr Pro 
    130                 135                 140                 


Leu Met Tyr Ala Cys Val Arg Gly Asp Glu Ala Met Val Gln Met Leu 
145                 150                 155                 160 


Leu Asp Ala Gly Ala Asp Leu Asn Val Glu Val Val Ser Thr Pro His 
                165                 170                 175     


Lys Tyr Pro Ser Val His Pro Glu Thr Arg His Trp Thr Ala Leu Thr 
            180                 185                 190         


Phe Ala Val Leu His Gly His Ile Pro Val Val Gln Leu Leu Leu Asp 
        195                 200                 205             


Ala Gly Ala Lys Val Glu Gly Ser Val Glu His Gly Glu Glu Asn Tyr 
    210                 215                 220                 


Ser Glu Thr Pro Leu Gln Leu Ala Ala Ala Val Gly Asn Phe Glu Leu 
225                 230                 235                 240 


Val Ser Leu Leu Leu Glu Arg Gly Ala Asp Pro Leu Ile Gly Thr Met 
                245                 250                 255     


Tyr Arg Asn Gly Ile Ser Thr Thr Pro Gln Gly Asp Met Asn Ser Phe 
            260                 265                 270         


Ser Gln Ala Ala Ala His Gly His Arg Asn Val Phe Arg Lys Leu Leu 
        275                 280                 285             


Ala Gln Pro Glu Lys Glu Lys Ser Asp Ile Leu Ser Leu Glu Glu Ile 
    290                 295                 300                 


Leu Ala Glu Gly Thr Asp Leu Ala Glu Thr Ala Pro Pro Pro Leu Cys 
305                 310                 315                 320 


Ala Ser Arg Asn Ser Lys Ala Lys Leu Arg Ala Leu Arg Glu Ala Met 
                325                 330                 335     


Tyr His Ser Ala Glu His Gly Tyr Val Asp Val Thr Ile Asp Ile Arg 
            340                 345                 350         


Ser Ile Gly Val Pro Trp Thr Leu His Thr Trp Leu Glu Ser Leu Arg 
        355                 360                 365             


Ile Ala Phe Gln Gln His Arg Arg Pro Leu Ile Gln Cys Leu Leu Lys 
    370                 375                 380                 


Glu Phe Lys Thr Ile Gln Glu Glu Glu Tyr Thr Glu Glu Leu Val Thr 
385                 390                 395                 400 


Gln Gly Leu Pro Leu Met Phe Glu Ile Leu Lys Ala Ser Lys Asn Glu 
                405                 410                 415     


Val Ile Ser Gln Gln Leu Cys Val Ile Phe Thr His Cys Tyr Gly Pro 
            420                 425                 430         


Tyr Pro Ile Pro Lys Leu Thr Glu Ile Lys Arg Lys Gln Thr Ser Arg 
        435                 440                 445             


Leu Asp Pro His Phe Leu Asn Asn Lys Glu Met Ser Asp Val Thr Phe 
    450                 455                 460                 


Leu Val Glu Gly Arg Pro Phe Tyr Ala His Lys Val Leu Leu Phe Thr 
465                 470                 475                 480 


Ala Ser Pro Arg Phe Lys Ala Leu Leu Ser Ser Lys Pro Thr Asn Asp 
                485                 490                 495     


Gly Thr Cys Ile Glu Ile Gly Tyr Val Lys Tyr Ser Ile Phe Gln Leu 
            500                 505                 510         


Val Met Gln Tyr Leu Tyr Tyr Gly Gly Pro Glu Ser Leu Leu Ile Lys 
        515                 520                 525             


Asn Asn Glu Ile Met Glu Leu Leu Ser Ala Ala Lys Phe Phe Gln Leu 
    530                 535                 540                 


Glu Ala Leu Gln Arg His Cys Glu Ile Ile Cys Ala Lys Ser Ile Asn 
545                 550                 555                 560 


Thr Asp Asn Cys Val Asp Ile Tyr Asn His Ala Lys Phe Leu Gly Val 
                565                 570                 575     


Thr Glu Leu Ser Ala Tyr Cys Glu Gly Tyr Phe Leu Lys Asn Met Met 
            580                 585                 590         


Val Leu Ile Glu Asn Glu Ala Phe Lys Gln Leu Leu Tyr Asp Lys Asn 
        595                 600                 605             


Gly Glu Gly Thr Gly Gln Asp Val Leu Gln Asp Leu Gln Arg Thr Leu 
    610                 615                 620                 


Ala Ile Arg Ile Gln Ser Ile His Leu Ser Ser Ser Lys Gly Ser Val 
625                 630                 635                 640 


Val 
    


<210>  1263
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD16__Homo_sapiens__NP_653188

<400>  1263

Met Ile Met Ser Asn Thr His Lys Ala Arg Leu Glu Arg Arg Val Thr 
1               5                   10                  15      


Gly Ser Thr Asn Arg Trp Arg Leu Pro Lys Gln Pro Phe Ser Gly Asp 
            20                  25                  30          


Leu Leu Ser Leu Ser Gln Met Cys Lys Ala Leu Ser Ile Asp Phe Glu 
        35                  40                  45              


Glu Ala Leu Arg Asn Pro Asp Arg Leu Cys Ile Ser Gln Ile Gln Lys 
    50                  55                  60                  


Phe Phe Phe Glu Asn Phe Lys Asn Lys Asp Ile Gln Ser Gly Glu Ala 
65                  70                  75                  80  


Asp Val Ile Leu Glu Cys Leu Gly Phe Lys Trp Glu Leu His Gln Pro 
                85                  90                  95      


Gln Leu Phe Gln Ser Glu Thr Leu Ala Lys Leu Tyr Leu Lys Ala Leu 
            100                 105                 110         


Ala Gln Gly Thr Thr His Pro Leu Arg Glu Leu Glu Glu Leu Leu Arg 
        115                 120                 125             


Ala Gln Ser Pro Lys Lys Thr Lys Glu Lys Ser Pro Ala Lys Arg Ile 
    130                 135                 140                 


Ile Ile Ser Leu Lys Ile Asn Asp Pro Leu Val Thr Lys Val Ala Phe 
145                 150                 155                 160 


Ala Thr Ala Leu Lys Asn Leu Tyr Met Ser Glu Val Glu Ile Asn Leu 
                165                 170                 175     


Glu Asp Leu Leu Gly Val Leu Ala Ser Ala His Ile Leu Gln Phe Ser 
            180                 185                 190         


Gly Leu Phe Gln Arg Cys Val Asp Val Met Ile Ala Arg Leu Lys Pro 
        195                 200                 205             


Ser Thr Ile Lys Lys Phe Tyr Glu Ala Gly Cys Lys Tyr Lys Glu Glu 
    210                 215                 220                 


Gln Leu Thr Thr Gly Cys Glu Lys Trp Leu Glu Met Asn Leu Val Pro 
225                 230                 235                 240 


Leu Gly Gly Thr Gln Ile His Leu His Lys Ile Pro Gln Asp Leu Leu 
                245                 250                 255     


His Lys Val Leu Lys Ser Pro Arg Leu Phe Thr Phe Ser Glu Phe His 
            260                 265                 270         


Leu Leu Lys Thr Met Leu Leu Trp Val Phe Leu Gln Leu Asn Tyr Lys 
        275                 280                 285             


Ile Gln Ala Ile Pro Thr Tyr Glu Thr Val Met Thr Phe Phe Lys Ser 
    290                 295                 300                 


Phe Pro Glu Asn Cys Cys Phe Leu Asp Arg Asp Ile Gly Arg Ser Leu 
305                 310                 315                 320 


Arg Pro Leu Phe Leu Cys Leu Arg Leu His Gly Ile Thr Lys Gly Lys 
                325                 330                 335     


Asp Leu Glu Val Leu Arg His Leu Asn Phe Phe Pro Glu Ser Trp Leu 
            340                 345                 350         


Asp Gln Val Thr Val Asn His Tyr His Ala Leu Glu Asn Gly Gly Asp 
        355                 360                 365             


Met Val His Leu Lys Asp Leu Asn Thr Gln Ala Val Arg Phe Gly Leu 
    370                 375                 380                 


Leu Phe Asn Gln Glu Asn Thr Thr Tyr Ser Lys Thr Ile Ala Leu Tyr 
385                 390                 395                 400 


Gly Phe Phe Phe Lys Ile Lys Gly Leu Lys His Asp Thr Thr Ser Tyr 
                405                 410                 415     


Ser Phe Tyr Met Gln Arg Ile Lys His Thr Asp Leu Glu Ser Pro Ser 
            420                 425                 430         


Ala Val Tyr Glu His Asn His Val Ser Leu Arg Ala Ala Arg Leu Val 
        435                 440                 445             


Lys Tyr Glu Ile Arg Ala Glu Ala Leu Val Asp Gly Lys Trp Gln Glu 
    450                 455                 460                 


Phe Arg Thr Asn Gln Ile Lys Gln Lys Phe Gly Leu Thr Thr Ser Ser 
465                 470                 475                 480 


Cys Lys Ser His Thr Leu Lys Ile Gln Thr Val Gly Ile Pro Ile Tyr 
                485                 490                 495     


Val Ser Phe Ala Phe Ile Phe Pro Ala Ser 
            500                 505     


<210>  1264
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD1__Homo_sapiens__NP_001011885

<400>  1264

Met Ala Ser Leu Gly Pro Ala Ala Ala Gly Glu Gln Ala Ser Gly Ala 
1               5                   10                  15      


Glu Ala Glu Pro Gly Pro Ala Gly Pro Pro Pro Pro Pro Ser Pro Ser 
            20                  25                  30          


Ser Leu Gly Pro Leu Leu Pro Leu Gln Arg Glu Pro Leu Tyr Asn Trp 
        35                  40                  45              


Gln Ala Thr Lys Ala Ser Leu Lys Glu Arg Phe Ala Phe Leu Phe Asn 
    50                  55                  60                  


Ser Glu Leu Leu Ser Asp Val Arg Phe Val Leu Gly Lys Gly Arg Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Gly Pro Gln Arg Ile Pro Ala His Arg Phe Val 
                85                  90                  95      


Leu Ala Ala Gly Ser Ala Val Phe Asp Ala Met Phe Asn Gly Gly Met 
            100                 105                 110         


Ala Thr Thr Ser Ala Glu Ile Glu Leu Pro Asp Val Glu Pro Ala Ala 
        115                 120                 125             


Phe Leu Ala Leu Leu Arg Phe Leu Tyr Ser Asp Glu Val Gln Ile Gly 
    130                 135                 140                 


Pro Glu Thr Val Met Thr Thr Leu Tyr Thr Ala Lys Lys Tyr Ala Val 
145                 150                 155                 160 


Pro Ala Leu Glu Ala His Cys Val Glu Phe Leu Thr Lys His Leu Arg 
                165                 170                 175     


Ala Asp Asn Ala Phe Met Leu Leu Thr Gln Ala Arg Leu Phe Asp Glu 
            180                 185                 190         


Pro Gln Leu Ala Ser Leu Cys Leu Asp Thr Ile Asp Lys Ser Thr Met 
        195                 200                 205             


Asp Ala Ile Ser Ala Glu Gly Phe Thr Asp Ile Asp Ile Asp Thr Leu 
    210                 215                 220                 


Cys Ala Val Leu Glu Arg Asp Thr Leu Ser Ile Arg Glu Ser Arg Leu 
225                 230                 235                 240 


Phe Gly Ala Val Val Arg Trp Ala Glu Ala Glu Cys Gln Arg Gln Gln 
                245                 250                 255     


Leu Pro Val Thr Phe Gly Asn Lys Gln Lys Val Leu Gly Lys Ala Leu 
            260                 265                 270         


Ser Leu Ile Arg Phe Pro Leu Met Thr Ile Glu Glu Phe Ala Ala Gly 
        275                 280                 285             


Pro Ala Gln Ser Gly Ile Leu Ser Asp Arg Glu Val Val Asn Leu Phe 
    290                 295                 300                 


Leu His Phe Thr Val Asn Pro Lys Pro Arg Val Glu Tyr Ile Asp Arg 
305                 310                 315                 320 


Pro Arg Cys Cys Leu Arg Gly Lys Glu Cys Cys Ile Asn Arg Phe Gln 
                325                 330                 335     


Gln Val Glu Ser Arg Trp Gly Tyr Ser Gly Thr Ser Asp Arg Ile Arg 
            340                 345                 350         


Ser Leu Asn Met Arg Lys Ser Lys Pro Trp Asp Arg Met Ile Pro Ala 
        355                 360                 365             


Leu Val Val Met Gly Gln Leu Thr His Ser Gly Ser Cys Ser Arg Asn 
    370                 375                 380                 


Pro 
385 


<210>  1265
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD2__Homo_sapiens__NP_060267

<400>  1265

Met Ala Ala Gly Gly Ser Gly Gly Arg Ala Ser Cys Pro Pro Gly Val 
1               5                   10                  15      


Gly Val Gly Pro Gly Thr Gly Gly Ser Pro Gly Pro Ser Ala Asn Ala 
            20                  25                  30          


Ala Ala Thr Pro Ala Pro Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Ala Pro Gly Pro Thr Pro Pro Ala Pro Pro Gly 
    50                  55                  60                  


Pro Gly Thr Asp Ala Gln Ala Ala Gly Ala Glu Arg Ala Glu Glu Ala 
65                  70                  75                  80  


Ala Gly Pro Gly Ala Ala Ala Leu Gln Arg Glu Ala Ala Tyr Asn Trp 
                85                  90                  95      


Gln Ala Ser Lys Pro Thr Val Gln Glu Arg Phe Ala Phe Leu Phe Asn 
            100                 105                 110         


Asn Glu Val Leu Cys Asp Val His Phe Leu Val Gly Lys Gly Leu Ser 
        115                 120                 125             


Ser Gln Arg Ile Pro Ala His Arg Phe Val Leu Ala Val Gly Ser Ala 
    130                 135                 140                 


Val Phe Asp Ala Met Phe Asn Gly Gly Met Ala Thr Thr Ser Thr Glu 
145                 150                 155                 160 


Ile Glu Leu Pro Asp Val Glu Pro Ala Ala Phe Leu Ala Leu Leu Lys 
                165                 170                 175     


Phe Leu Tyr Ser Asp Glu Val Gln Ile Gly Pro Glu Thr Val Met Thr 
            180                 185                 190         


Thr Leu Tyr Thr Ala Lys Lys Tyr Ala Val Pro Ala Leu Glu Ala His 
        195                 200                 205             


Cys Val Glu Phe Leu Lys Lys Asn Leu Arg Ala Asp Asn Ala Phe Met 
    210                 215                 220                 


Leu Leu Thr Gln Ala Arg Leu Phe Asp Glu Pro Gln Leu Ala Ser Leu 
225                 230                 235                 240 


Cys Leu Glu Asn Ile Asp Lys Asn Thr Ala Asp Ala Ile Thr Ala Glu 
                245                 250                 255     


Gly Phe Thr Asp Ile Asp Leu Asp Thr Leu Val Ala Val Leu Glu Arg 
            260                 265                 270         


Asp Thr Leu Gly Ile Arg Glu Val Arg Leu Phe Asn Ala Val Val Arg 
        275                 280                 285             


Trp Ser Glu Ala Glu Cys Gln Arg Gln Gln Leu Gln Val Thr Pro Glu 
    290                 295                 300                 


Asn Arg Arg Lys Val Leu Gly Lys Ala Leu Gly Leu Ile Arg Phe Pro 
305                 310                 315                 320 


Leu Met Thr Ile Glu Glu Phe Ala Ala Gly Pro Ala Gln Ser Gly Ile 
                325                 330                 335     


Leu Val Asp Arg Glu Val Val Ser Leu Phe Leu His Phe Thr Val Asn 
            340                 345                 350         


Pro Lys Pro Arg Val Glu Phe Ile Asp Arg Pro Arg Cys Cys Leu Arg 
        355                 360                 365             


Gly Lys Glu Cys Ser Ile Asn Arg Phe Gln Gln Val Glu Ser Arg Trp 
    370                 375                 380                 


Gly Tyr Ser Gly Thr Ser Asp Arg Ile Arg Phe Ser Val Asn Lys Arg 
385                 390                 395                 400 


Ile Phe Val Val Gly Phe Gly Leu Tyr Gly Ser Ile His Gly Pro Thr 
                405                 410                 415     


Asp Tyr Gln Val Asn Ile Gln Ile Ile His Thr Asp Ser Asn Thr Val 
            420                 425                 430         


Leu Gly Gln Asn Asp Thr Gly Phe Ser Cys Asp Gly Ser Ala Ser Thr 
        435                 440                 445             


Phe Arg Val Met Phe Lys Glu Pro Val Glu Val Leu Pro Asn Val Asn 
    450                 455                 460                 


Tyr Thr Ala Cys Ala Thr Leu Lys Gly Pro Asp Ser His Tyr Gly Thr 
465                 470                 475                 480 


Lys Gly Leu Arg Lys Val Thr His Glu Ser Pro Thr Thr Gly Ala Lys 
                485                 490                 495     


Thr Cys Phe Thr Phe Cys Tyr Ala Ala Gly Asn Asn Asn Gly Thr Ser 
            500                 505                 510         


Val Glu Asp Gly Gln Ile Pro Glu Val Ile Phe Tyr Thr 
        515                 520                 525 


<210>  1266
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD3__Homo_sapiens__NP_001269480

<400>  1266

Met Ala Ala Asp Ile Phe Pro Arg Lys Lys Pro Ala Asn Ser Ser Ser 
1               5                   10                  15      


Thr Ser Val Gln Gln Tyr His Gln Gln Asn Leu Ser Asn Asn Asn Leu 
            20                  25                  30          


Ile Pro Ala Pro Asn Trp Gln Gly Leu Tyr Pro Thr Ile Arg Glu Arg 
        35                  40                  45              


Asn Ala Met Met Phe Asn Asn Asp Leu Met Ala Asp Val His Phe Val 
    50                  55                  60                  


Val Gly Pro Pro Gly Gly Thr Gln Arg Leu Pro Gly His Lys Tyr Val 
65                  70                  75                  80  


Leu Ala Val Gly Ser Ser Val Phe His Ala Met Phe Tyr Gly Glu Leu 
                85                  90                  95      


Ala Glu Asp Lys Asp Glu Ile Arg Ile Pro Asp Val Glu Pro Ala Ala 
            100                 105                 110         


Phe Leu Ala Met Leu Lys Tyr Ile Tyr Cys Asp Glu Ile Asp Leu Ala 
        115                 120                 125             


Ala Asp Thr Val Leu Ala Thr Leu Tyr Ala Ala Lys Lys Tyr Ile Val 
    130                 135                 140                 


Pro His Leu Ala Arg Ala Cys Val Asn Phe Leu Glu Thr Ser Leu Ser 
145                 150                 155                 160 


Ala Lys Asn Ala Cys Val Leu Leu Ser Gln Ser Cys Leu Phe Glu Glu 
                165                 170                 175     


Pro Asp Leu Thr Gln Arg Cys Trp Glu Val Ile Asp Ala Gln Ala Glu 
            180                 185                 190         


Leu Ala Leu Lys Ser Glu Gly Phe Cys Asp Ile Asp Phe Gln Thr Leu 
        195                 200                 205             


Glu Ser Ile Leu Arg Arg Glu Thr Leu Asn Ala Lys Glu Ile Val Val 
    210                 215                 220                 


Phe Glu Ala Ala Leu Asn Trp Ala Glu Val Glu Cys Gln Arg Gln Asp 
225                 230                 235                 240 


Leu Ala Leu Ser Ile Glu Asn Lys Arg Lys Val Leu Gly Lys Ala Leu 
                245                 250                 255     


Tyr Leu Ile Arg Ile Pro Thr Met Ala Leu Asp Asp Phe Ala Asn Gly 
            260                 265                 270         


Ala Ala Gln Ser Gly Val Leu Thr Leu Asn Glu Thr Asn Asp Ile Phe 
        275                 280                 285             


Leu Trp Tyr Thr Ala Ala Lys Lys Pro Glu Leu Gln Phe Val Ser Lys 
    290                 295                 300                 


Ala Arg Lys Gly Leu Val Pro Gln Arg Cys His Arg Phe Gln Ser Cys 
305                 310                 315                 320 


Ala Tyr Arg Ser Asn Gln Trp Arg Tyr Arg Gly Arg Cys Asp Ser Ile 
                325                 330                 335     


Gln Phe Ala Val Asp Lys Arg Val Phe Ile Ala Gly Phe Gly Leu Tyr 
            340                 345                 350         


Gly Ser Ser Cys Gly Ser Ala Glu Tyr Ser Ala Lys Ile Glu Leu Lys 
        355                 360                 365             


Arg Gln Gly Val Val Leu Gly Gln Asn Leu Ser Lys Tyr Phe Ser Asp 
    370                 375                 380                 


Gly Ser Ser Asn Thr Phe Pro Val Trp Phe Glu Tyr Pro Val Gln Ile 
385                 390                 395                 400 


Glu Pro Asp Thr Phe Tyr Thr Ala Ser Val Ile Leu Asp Gly Asn Glu 
                405                 410                 415     


Leu Ser Tyr Phe Gly Gln Glu Gly Met Thr Glu Val Gln Cys Gly Lys 
            420                 425                 430         


Val Thr Val Gln Phe Gln Cys Ser Ser Asp Ser Thr Asn Gly Thr Gly 
        435                 440                 445             


Val Gln Gly Gly Gln Ile Pro Glu Leu Ile Phe Tyr Ala 
    450                 455                 460     


<210>  1267
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD9__Homo_sapiens__NP_001165889

<400>  1267

Met Cys Arg Ala Leu Leu Tyr Gly Gly Met Arg Glu Ser Gln Pro Glu 
1               5                   10                  15      


Ala Glu Ile Pro Leu Gln Asp Thr Thr Ala Glu Ala Phe Thr Met Leu 
            20                  25                  30          


Leu Lys Tyr Ile Tyr Thr Gly Arg Ala Thr Leu Thr Asp Glu Lys Glu 
        35                  40                  45              


Glu Val Leu Leu Asp Phe Leu Ser Leu Ala His Lys Tyr Gly Phe Pro 
    50                  55                  60                  


Glu Leu Glu Asp Ser Thr Ser Glu Tyr Leu Cys Thr Ile Leu Asn Ile 
65                  70                  75                  80  


Gln Asn Val Cys Met Thr Phe Asp Val Ala Ser Leu Tyr Ser Leu Pro 
                85                  90                  95      


Lys Leu Thr Cys Met Cys Cys Met Phe Met Asp Arg Asn Ala Gln Glu 
            100                 105                 110         


Val Leu Ser Ser Glu Gly Phe Leu Ser Leu Ser Lys Thr Ala Leu Leu 
        115                 120                 125             


Asn Ile Val Leu Arg Asp Ser Phe Ala Ala Pro Glu Lys Asp Ile Phe 
    130                 135                 140                 


Leu Ala Leu Leu Asn Trp Cys Lys His Asn Ser Lys Glu Asn His Ala 
145                 150                 155                 160 


Glu Ile Met Gln Ala Val Arg Leu Pro Leu Met Ser Leu Thr Glu Leu 
                165                 170                 175     


Leu Asn Val Val Arg Pro Ser Gly Leu Leu Ser Pro Asp Ala Ile Leu 
            180                 185                 190         


Asp Ala Ile Lys Val Arg Ser Glu Ser Arg Asp Met Asp Leu Asn Tyr 
        195                 200                 205             


Arg Gly Met Leu Ile Pro Glu Glu Asn Ile Ala Thr Met Lys Tyr Gly 
    210                 215                 220                 


Ala Gln Val Val Lys Gly Glu Leu Lys Ser Ala Leu Leu Asp Gly Asp 
225                 230                 235                 240 


Thr Gln Asn Tyr Asp Leu Asp His Gly Phe Ser Arg His Pro Ile Asp 
                245                 250                 255     


Asp Asp Cys Arg Ser Gly Ile Glu Ile Lys Leu Gly Gln Pro Ser Ile 
            260                 265                 270         


Ile Asn His Ile Arg Ile Leu Leu Trp Asp Arg Asp Ser Arg Ser Tyr 
        275                 280                 285             


Ser Tyr Phe Ile Glu Val Ser Met Asp Glu Leu Asp Trp Val Arg Val 
    290                 295                 300                 


Ile Asp His Ser Gln Tyr Leu Cys Arg Ser Trp Gln Lys Leu Tyr Phe 
305                 310                 315                 320 


Pro Ala Arg Val Cys Ser Gly Asp Gly Val Ser Leu Trp Cys Pro Leu 
                325                 330                 335     


Trp Ser Arg Thr Pro Glu Leu Lys Gln Ser Ser Leu Leu Gly Leu Pro 
            340                 345                 350         


Lys Cys Arg Tyr Ile Arg Ile Val Gly Thr His Asn Thr Val Asn Lys 
        355                 360                 365             


Ile Phe His Ile Val Ala Phe Glu Cys Met Phe Thr Asn Lys Thr Phe 
    370                 375                 380                 


Thr Leu Glu Lys Gly Leu Ile Val Pro Met Glu Asn Val Ala Thr Ile 
385                 390                 395                 400 


Ala Asp Cys Ala Ser Val Ile Glu Gly Val Ser Arg Ser Arg Asn Ala 
                405                 410                 415     


Leu Leu Asn Gly Asp Thr Lys Asn Tyr Asp Trp Asp Ser Gly Tyr Thr 
            420                 425                 430         


Cys His Gln Leu Gly Ser Gly Ala Ile Val Val Gln Leu Ala Gln Pro 
        435                 440                 445             


Tyr Met Ile Gly Ser Ile Arg Leu Leu Leu Trp Asp Cys Asp Asp Arg 
    450                 455                 460                 


Ser Tyr Ser Tyr Tyr Val Glu Val Ser Thr Asn Gln Gln Gln Trp Thr 
465                 470                 475                 480 


Met Val Ala Asp Arg Thr Lys Val Ser Cys Lys Ser Trp Gln Ser Val 
                485                 490                 495     


Thr Phe Glu Arg Gln Pro Ala Ser Phe Ile Arg Ile Val Gly Thr His 
            500                 505                 510         


Asn Thr Ala Asn Glu Val Phe His Cys Val His Phe Glu Cys Pro Glu 
        515                 520                 525             


Gln Gln Ser Ser Gln Lys Glu Glu Asn Ser Glu Glu Ser Gly Thr Gly 
    530                 535                 540                 


Asp Thr Ser Leu Ala Gly Gln Gln Leu Asp Ser His Ala Leu Arg Ala 
545                 550                 555                 560 


Pro Ser Gly Ser Ser Leu Pro Ser Ser Pro Gly Ser Asn Ser Arg Ser 
                565                 570                 575     


Pro Asn Arg Gln His Gln 
            580         


<210>  1268
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTC__Homo_sapiens__NP_001720

<400>  1268

Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly Asp 
        35                  40                  45              


Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys Gly 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp 
                85                  90                  95      


Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Leu Ile Ala Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Thr 
145                 150                 155                 160 


Leu Gly Lys Asp Ile Thr Pro Ile Asn Glu Asp Ile Glu Glu Thr Asn 
                165                 170                 175     


Ile Ala 
        


<210>  1269
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTD__Homo_sapiens__NP_000051

<400>  1269

Met Ala His Ala His Ile Gln Gly Gly Arg Arg Ala Lys Ser Arg Phe 
1               5                   10                  15      


Val Val Cys Ile Met Ser Gly Ala Arg Ser Lys Leu Ala Leu Phe Leu 
            20                  25                  30          


Cys Gly Cys Tyr Val Val Ala Leu Gly Ala His Thr Gly Glu Glu Ser 
        35                  40                  45              


Val Ala Asp His His Glu Ala Glu Tyr Tyr Val Ala Ala Val Tyr Glu 
    50                  55                  60                  


His Pro Ser Ile Leu Ser Leu Asn Pro Leu Ala Leu Ile Ser Arg Gln 
65                  70                  75                  80  


Glu Ala Leu Glu Leu Met Asn Gln Asn Leu Asp Ile Tyr Glu Gln Gln 
                85                  90                  95      


Val Met Thr Ala Ala Gln Lys Asp Val Gln Ile Ile Val Phe Pro Glu 
            100                 105                 110         


Asp Gly Ile His Gly Phe Asn Phe Thr Arg Thr Ser Ile Tyr Pro Phe 
        115                 120                 125             


Leu Asp Phe Met Pro Ser Pro Gln Val Val Arg Trp Asn Pro Cys Leu 
    130                 135                 140                 


Glu Pro His Arg Phe Asn Asp Thr Glu Val Leu Gln Arg Leu Ser Cys 
145                 150                 155                 160 


Met Ala Ile Arg Gly Asp Met Phe Leu Val Ala Asn Leu Gly Thr Lys 
                165                 170                 175     


Glu Pro Cys His Ser Ser Asp Pro Arg Cys Pro Lys Asp Gly Arg Tyr 
            180                 185                 190         


Gln Phe Asn Thr Asn Val Val Phe Ser Asn Asn Gly Thr Leu Val Asp 
        195                 200                 205             


Arg Tyr Arg Lys His Asn Leu Tyr Phe Glu Ala Ala Phe Asp Val Pro 
    210                 215                 220                 


Leu Lys Val Asp Leu Ile Thr Phe Asp Thr Pro Phe Ala Gly Arg Phe 
225                 230                 235                 240 


Gly Ile Phe Thr Cys Phe Asp Ile Leu Phe Phe Asp Pro Ala Ile Arg 
                245                 250                 255     


Val Leu Arg Asp Tyr Lys Val Lys His Val Val Tyr Pro Thr Ala Trp 
            260                 265                 270         


Met Asn Gln Leu Pro Leu Leu Ala Ala Ile Glu Ile Gln Lys Ala Phe 
        275                 280                 285             


Ala Val Ala Phe Gly Ile Asn Val Leu Ala Ala Asn Val His His Pro 
    290                 295                 300                 


Val Leu Gly Met Thr Gly Ser Gly Ile His Thr Pro Leu Glu Ser Phe 
305                 310                 315                 320 


Trp Tyr His Asp Met Glu Asn Pro Lys Ser His Leu Ile Ile Ala Gln 
                325                 330                 335     


Val Ala Lys Asn Pro Val Gly Leu Ile Gly Ala Glu Asn Ala Thr Gly 
            340                 345                 350         


Glu Thr Asp Pro Ser His Ser Lys Phe Leu Lys Ile Leu Ser Gly Asp 
        355                 360                 365             


Pro Tyr Cys Glu Lys Asp Ala Gln Glu Val His Cys Asp Glu Ala Thr 
    370                 375                 380                 


Lys Trp Asn Val Asn Ala Pro Pro Thr Phe His Ser Glu Met Met Tyr 
385                 390                 395                 400 


Asp Asn Phe Thr Leu Val Pro Val Trp Gly Lys Glu Gly Tyr Leu His 
                405                 410                 415     


Val Cys Ser Asn Gly Leu Cys Cys Tyr Leu Leu Tyr Glu Arg Pro Thr 
            420                 425                 430         


Leu Ser Lys Glu Leu Tyr Ala Leu Gly Val Phe Asp Gly Leu His Thr 
        435                 440                 445             


Val His Gly Thr Tyr Tyr Ile Gln Val Cys Ala Leu Val Arg Cys Gly 
    450                 455                 460                 


Gly Leu Gly Phe Asp Thr Cys Gly Gln Glu Ile Thr Glu Ala Thr Gly 
465                 470                 475                 480 


Ile Phe Glu Phe His Leu Trp Gly Asn Phe Ser Thr Ser Tyr Ile Phe 
                485                 490                 495     


Pro Leu Phe Leu Thr Ser Gly Met Thr Leu Glu Val Pro Asp Gln Leu 
            500                 505                 510         


Gly Trp Glu Asn Asp His Tyr Phe Leu Arg Lys Ser Arg Leu Ser Ser 
        515                 520                 525             


Gly Leu Val Thr Ala Ala Leu Tyr Gly Arg Leu Tyr Glu Arg Asp 
    530                 535                 540             


<210>  1270
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTF3__Homo_sapiens__NP_001032726

<400>  1270

Met Arg Arg Thr Gly Ala Pro Ala Gln Ala Asp Ser Arg Gly Arg Gly 
1               5                   10                  15      


Arg Ala Arg Gly Gly Cys Pro Gly Gly Glu Ala Thr Leu Ser Gln Pro 
            20                  25                  30          


Pro Pro Arg Gly Gly Thr Arg Gly Gln Glu Pro Gln Met Lys Glu Thr 
        35                  40                  45              


Ile Met Asn Gln Glu Lys Leu Ala Lys Leu Gln Ala Gln Val Arg Ile 
    50                  55                  60                  


Gly Gly Lys Gly Thr Ala Arg Arg Lys Lys Lys Val Val His Arg Thr 
65                  70                  75                  80  


Ala Thr Ala Asp Asp Lys Lys Leu Gln Phe Ser Leu Lys Lys Leu Gly 
                85                  90                  95      


Val Asn Asn Ile Ser Gly Ile Glu Glu Val Asn Met Phe Thr Asn Gln 
            100                 105                 110         


Gly Thr Val Ile His Phe Asn Asn Pro Lys Val Gln Ala Ser Leu Ala 
        115                 120                 125             


Ala Asn Thr Phe Thr Ile Thr Gly His Ala Glu Thr Lys Gln Leu Thr 
    130                 135                 140                 


Glu Met Leu Pro Ser Ile Leu Asn Gln Leu Gly Ala Asp Ser Leu Thr 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Ala Glu Ala Leu Pro Lys Gln Ser Val Asp Gly 
                165                 170                 175     


Lys Ala Pro Leu Ala Thr Gly Glu Asp Asp Asp Asp Glu Val Pro Asp 
            180                 185                 190         


Leu Val Glu Asn Phe Asp Glu Ala Ser Lys Asn Glu Ala Asn 
        195                 200                 205     


<210>  1271
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTG1__Homo_sapiens__NP_001722

<400>  1271

Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile Ala 
1               5                   10                  15      


Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu Thr 
            20                  25                  30          


Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu Leu 
        35                  40                  45              


Ala Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys Gly 
    50                  55                  60                  


Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu Ile 
65                  70                  75                  80  


Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Ser Gln Glu Leu Phe Arg 
                85                  90                  95      


Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser 
            100                 105                 110         


Tyr Arg Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala Ser 
        115                 120                 125             


Pro Ala Gly Gly Ser Thr Gln Asn Ser Thr Asn Val Gln Met Val Asp 
    130                 135                 140                 


Ser Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser Pro 
145                 150                 155                 160 


Ser Lys Asn Tyr Asn Met Met Thr Val Ser Gly 
                165                 170     


<210>  1272
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTG2__Homo_sapiens__NP_006754

<400>  1272

Met Ser His Gly Lys Gly Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
1               5                   10                  15      


Val Gly Phe Leu Ser Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
            20                  25                  30          


Gln Arg Leu Lys Val Phe Ser Gly Ala Leu Gln Glu Ala Leu Thr Glu 
        35                  40                  45              


His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
    50                  55                  60                  


Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Arg 
65                  70                  75                  80  


Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                85                  90                  95      


Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
            100                 105                 110         


Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Leu 
        115                 120                 125             


Ala Ala Ser Cys Gly Leu Leu Thr Cys Lys Asn Gln Val Leu Leu Gly 
    130                 135                 140                 


Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Ala Val Ser Ser 
145                 150                 155             


<210>  1273
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTG3__Homo_sapiens__NP_001124386

<400>  1273

Met Lys Asn Glu Ile Ala Ala Val Val Phe Phe Phe Thr Arg Leu Val 
1               5                   10                  15      


Arg Lys His Asp Lys Leu Lys Lys Glu Ala Val Glu Arg Phe Ala Glu 
            20                  25                  30          


Lys Leu Thr Leu Ile Leu Gln Glu Lys Tyr Lys Asn His Trp Tyr Pro 
        35                  40                  45              


Glu Lys Pro Ser Lys Gly Gln Ala Tyr Arg Cys Ile Arg Val Asn Lys 
    50                  55                  60                  


Phe Gln Arg Val Asp Pro Asp Val Leu Lys Ala Cys Glu Asn Ser Cys 
65                  70                  75                  80  


Ile Leu Tyr Ser Asp Leu Gly Leu Pro Lys Glu Leu Thr Leu Trp Val 
                85                  90                  95      


Asp Pro Cys Glu Val Cys Cys Arg Arg Asp Gly Val Ser Pro Cys Trp 
            100                 105                 110         


Pro Asp Cys Ser Gln Thr Pro Asp Leu Val Ile Arg Pro Pro Trp Pro 
        115                 120                 125             


Pro Lys Ala Leu Asp Tyr Arg Arg Glu Pro Leu Arg Pro Ala Ser Ser 
    130                 135                 140                 


Phe Leu Ile Met Tyr Gly Glu Lys Asn Asn Ala Phe Ile Val Ala Ser 
145                 150                 155                 160 


Phe Glu Asn Lys Asp Glu Asn Lys Asp Glu Ile Ser Arg Lys Val Thr 
                165                 170                 175     


Arg Ala Leu Asp Lys Val Thr Ser Asp Tyr His Ser Gly Ser Ser Ser 
            180                 185                 190         


Ser Asp Glu Glu Thr Ser Lys Glu Met Glu Val Lys Pro Ser Ser Val 
        195                 200                 205             


Thr Ala Ala Ala Ser Pro Val Tyr Gln Ile Ser Glu Leu Ile Phe Pro 
    210                 215                 220                 


Pro Leu Pro Met Trp His Pro Leu Pro Arg Lys Lys Pro Gly Met Tyr 
225                 230                 235                 240 


Arg Gly Asn Gly His Gln Asn His Tyr Pro Pro Pro Val Pro Phe Gly 
                245                 250                 255     


Tyr Pro Asn Gln Gly Arg Lys Asn Lys Pro Tyr Arg Pro Ile Pro Val 
            260                 265                 270         


Thr Trp Val Pro Pro Pro Gly Met His Cys Asp Arg Asn His Trp Ile 
        275                 280                 285             


Asn Pro His Met Leu Ala Pro His 
    290                 295     


<210>  1274
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTG4__Homo_sapiens__NP_060059

<400>  1274

Met Arg Asp Glu Ile Ala Thr Thr Val Phe Phe Val Thr Arg Leu Val 
1               5                   10                  15      


Lys Lys His Asp Lys Leu Ser Lys Gln Gln Ile Glu Asp Phe Ala Glu 
            20                  25                  30          


Lys Leu Met Thr Ile Leu Phe Glu Thr Tyr Arg Ser His Trp His Ser 
        35                  40                  45              


Asp Cys Pro Ser Lys Gly Gln Ala Phe Arg Cys Ile Arg Ile Asn Asn 
    50                  55                  60                  


Asn Gln Asn Lys Asp Pro Ile Leu Glu Arg Ala Cys Val Glu Ser Asn 
65                  70                  75                  80  


Val Asp Phe Ser His Leu Gly Leu Pro Lys Glu Met Thr Ile Trp Val 
                85                  90                  95      


Asp Pro Phe Glu Val Cys Cys Arg Tyr Gly Glu Lys Asn His Pro Phe 
            100                 105                 110         


Thr Val Ala Ser Phe Lys Gly Arg Trp Glu Glu Trp Glu Leu Tyr Gln 
        115                 120                 125             


Gln Ile Ser Tyr Ala Val Ser Arg Ala Ser Ser Asp Val Ser Ser Gly 
    130                 135                 140                 


Thr Ser Cys Asp Glu Glu Ser Cys Ser Lys Glu Pro Arg Val Ile Pro 
145                 150                 155                 160 


Lys Val Ser Asn Pro Lys Ser Ile Tyr Gln Val Glu Asn Leu Lys Gln 
                165                 170                 175     


Pro Phe Gln Ser Trp Leu Gln Ile Pro Arg Lys Lys Asn Val Val Asp 
            180                 185                 190         


Gly Arg Val Gly Leu Leu Gly Asn Thr Tyr His Gly Ser Gln Lys His 
        195                 200                 205             


Pro Lys Cys Tyr Arg Pro Ala Met His Arg Leu Asp Arg Ile Leu 
    210                 215                 220             


<210>  1275
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTK__Homo_sapiens__NP_000052

<400>  1275

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  1276
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTLA__Homo_sapiens__NP_001078826

<400>  1276

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
    130                 135                 140                 


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
145                 150                 155                 160 


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
                165                 170                 175     


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
            180                 185                 190         


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
        195                 200                 205             


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
    210                 215                 220                 


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
225                 230                 235                 240 


Ser 
    


<210>  1277
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTN1A1__Homo_sapiens__NP_001723

<400>  1277

Met Ala Val Phe Pro Ser Ser Gly Leu Pro Arg Cys Leu Leu Thr Leu 
1               5                   10                  15      


Ile Leu Leu Gln Leu Pro Lys Leu Asp Ser Ala Pro Phe Asp Val Ile 
            20                  25                  30          


Gly Pro Pro Glu Pro Ile Leu Ala Val Val Gly Glu Asp Ala Glu Leu 
        35                  40                  45              


Pro Cys Arg Leu Ser Pro Asn Ala Ser Ala Glu His Leu Glu Leu Arg 
    50                  55                  60                  


Trp Phe Arg Lys Lys Val Ser Pro Ala Val Leu Val His Arg Asp Gly 
65                  70                  75                  80  


Arg Glu Gln Glu Ala Glu Gln Met Pro Glu Tyr Arg Gly Arg Ala Thr 
                85                  90                  95      


Leu Val Gln Asp Gly Ile Ala Lys Gly Arg Val Ala Leu Arg Ile Arg 
            100                 105                 110         


Gly Val Arg Val Ser Asp Asp Gly Glu Tyr Thr Cys Phe Phe Arg Glu 
        115                 120                 125             


Asp Gly Ser Tyr Glu Glu Ala Leu Val His Leu Lys Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Asp Pro His Ile Ser Met Gln Val Gln Glu Asn Gly Glu Ile 
145                 150                 155                 160 


Cys Leu Glu Cys Thr Ser Val Gly Trp Tyr Pro Glu Pro Gln Val Gln 
                165                 170                 175     


Trp Arg Thr Ser Lys Gly Glu Lys Phe Pro Ser Thr Ser Glu Ser Arg 
            180                 185                 190         


Asn Pro Asp Glu Glu Gly Leu Phe Thr Val Ala Ala Ser Val Ile Ile 
        195                 200                 205             


Arg Asp Thr Ser Ala Lys Asn Val Ser Cys Tyr Ile Gln Asn Leu Leu 
    210                 215                 220                 


Leu Gly Gln Glu Lys Lys Val Glu Ile Ser Ile Pro Ala Ser Ser Leu 
225                 230                 235                 240 


Pro Arg Leu Thr Pro Trp Ile Val Ala Val Ala Val Ile Leu Met Val 
                245                 250                 255     


Leu Gly Leu Leu Thr Ile Gly Ser Ile Phe Phe Thr Trp Arg Leu Tyr 
            260                 265                 270         


Asn Glu Arg Pro Arg Glu Arg Arg Asn Glu Phe Ser Ser Lys Glu Arg 
        275                 280                 285             


Leu Leu Glu Glu Leu Lys Trp Lys Lys Ala Thr Leu His Ala Val Asp 
    290                 295                 300                 


Val Thr Leu Asp Pro Asp Thr Ala His Pro His Leu Phe Leu Tyr Glu 
305                 310                 315                 320 


Asp Ser Lys Ser Val Arg Leu Glu Asp Ser Arg Gln Lys Leu Pro Glu 
                325                 330                 335     


Lys Thr Glu Arg Phe Asp Ser Trp Pro Cys Val Leu Gly Arg Glu Thr 
            340                 345                 350         


Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg Thr 
        355                 360                 365             


Asp Trp Ala Ile Gly Val Cys Arg Glu Asn Val Met Lys Lys Gly Phe 
    370                 375                 380                 


Asp Pro Met Thr Pro Glu Asn Gly Phe Trp Ala Val Glu Leu Tyr Gly 
385                 390                 395                 400 


Asn Gly Tyr Trp Ala Leu Thr Pro Leu Arg Thr Pro Leu Pro Leu Ala 
                405                 410                 415     


Gly Pro Pro Arg Arg Val Gly Ile Phe Leu Asp Tyr Glu Ser Gly Asp 
            420                 425                 430         


Ile Ser Phe Tyr Asn Met Asn Asp Gly Ser Asp Ile Tyr Thr Phe Ser 
        435                 440                 445             


Asn Val Thr Phe Ser Gly Pro Leu Arg Pro Phe Phe Cys Leu Trp Ser 
    450                 455                 460                 


Ser Gly Lys Lys Pro Leu Thr Ile Cys Pro Ile Ala Asp Gly Pro Glu 
465                 470                 475                 480 


Arg Val Thr Val Ile Ala Asn Ala Gln Asp Leu Ser Lys Glu Ile Pro 
                485                 490                 495     


Leu Ser Pro Met Gly Glu Asp Ser Ala Pro Arg Asp Ala Asp Thr Leu 
            500                 505                 510         


His Ser Lys Leu Ile Pro Thr Gln Pro Ser Gln Gly Ala Pro 
        515                 520                 525     


<210>  1278
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTN2A1__Homo_sapiens__NP_001184162

<400>  1278

Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val 
1               5                   10                  15      


Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg 
            20                  25                  30          


Gly Arg Thr Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala 
        35                  40                  45              


Leu Val Ile His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys 
    50                  55                  60                  


Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val 
65                  70                  75                  80  


Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu 
                85                  90                  95      


Asp Gly Gly Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys 
            100                 105                 110         


Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu 
        115                 120                 125             


Lys Glu Val Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr 
    130                 135                 140                 


Ala Val Ile Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile 
145                 150                 155                 160 


Asn Asn Thr Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro 
                165                 170                 175     


Glu Ser Phe Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile 
            180                 185                 190         


Ile Val Val Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile 
        195                 200                 205             


Asn Lys Leu Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe 
    210                 215                 220                 


Glu Arg Glu Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg 
225                 230                 235                 240 


Val Gln Lys Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu 
                245                 250                 255     


Leu Arg Trp Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp 
            260                 265                 270         


Pro Asp Thr Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser 
        275                 280                 285             


Val Arg Arg Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn 
    290                 295                 300                 


Pro Glu Arg Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe 
305                 310                 315                 320 


Ala Ser Gly Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu 
                325                 330                 335     


Trp Thr Val Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val 
            340                 345                 350         


Leu Leu Ile Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly 
        355                 360                 365             


Gln Tyr Arg Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu 
    370                 375                 380                 


Ser Leu Cys Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val 
385                 390                 395                 400 


Ser Phe Tyr Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg 
                405                 410                 415     


Ser Ala Phe Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu 
            420                 425                 430         


Asp Ser Pro Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val 
        435                 440                 445             


Thr Val Pro Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln 
    450                 455                 460                 


Ser Leu 
465     


<210>  1279
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTN2A2__Homo_sapiens__NP_001184166

<400>  1279

Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile 
225                 230                 235                 240 


Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala 
                245                 250                 255     


Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu 
            260                 265                 270         


Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys 
        275                 280                 285             


Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln 
    290                 295                 300                 


Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg 
305                 310                 315                 320 


Arg Thr Phe Leu His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala 
                325                 330                 335     


His Pro Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly 
            340                 345                 350         


Pro Tyr Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln 
        355                 360                 365             


Pro Cys Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp 
    370                 375                 380                 


Glu Val Glu Val Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg 
385                 390                 395                 400 


His Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly 
                405                 410                 415     


Phe Trp Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser 
            420                 425                 430         


Pro Glu Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val 
        435                 440                 445             


Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp 
    450                 455                 460                 


Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val 
465                 470                 475                 480 


Arg Pro Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys 
                485                 490                 495     


Pro Ala Leu Thr Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu 
            500                 505                 510         


Lys Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520             


<210>  1280
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTN3A1__Homo_sapiens__NP_001138480

<400>  1280

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met Arg Gly 
145                 150                 155                 160 


Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser Ser Leu Leu Gly 
                165                 170                 175     


Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro Phe Phe Arg Ser 
            180                 185                 190         


Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu Pro Val Leu Leu 
        195                 200                 205             


Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln Gln Gln Glu Glu 
    210                 215                 220                 


Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln Glu Leu Arg Glu 
225                 230                 235                 240 


Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr Arg Val Lys Leu 
                245                 250                 255     


Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala Ser Arg Gly Glu 
            260                 265                 270         


Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu Phe Lys Pro Ala 
        275                 280                 285             


Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile Leu Leu Val Ser 
    290                 295                 300                 


Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro Gln Asp Leu Pro 
305                 310                 315                 320 


Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val Leu Gly Cys Glu 
                325                 330                 335     


Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg 
            340                 345                 350         


Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val Gln Arg Lys Gly 
        355                 360                 365             


Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr Met Gly Leu Thr 
    370                 375                 380                 


Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg Thr Asn Leu Lys 
385                 390                 395                 400 


Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu Asp Tyr Glu Thr 
                405                 410                 415     


Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser His Ile His Thr 
            420                 425                 430         


Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro Val Phe Arg Ile 
        435                 440                 445             


Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro Ala 
    450                 455                 460     


<210>  1281
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTN3A2__Homo_sapiens__NP_001184175

<400>  1281

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  1282
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTN3A3__Homo_sapiens__NP_008925

<400>  1282

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Arg Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Ile Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Lys Trp Ser Asp Thr Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Gly Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Ser Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Lys Ile Ala Leu Ser Arg Glu Thr Glu Arg Glu Arg 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Gln Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Lys Leu Gln Glu Glu Leu Lys Trp Arg Lys Ile Gln Tyr Met 
305                 310                 315                 320 


Ala Arg Gly Glu Lys Ser Leu Ala Tyr His Glu Trp Lys Met Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Asp Thr Ala Asn Ala Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Glu Glu Pro 
        355                 360                 365             


Arg Asp Leu Pro Asp Asn Pro Glu Arg Phe Glu Trp Arg Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Asn Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Glu Arg Lys Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Tyr Trp 
            420                 425                 430         


Thr Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Ala Leu Thr Glu Pro 
        435                 440                 445             


Arg Thr Asn Leu Lys Leu Pro Glu Pro Pro Arg Lys Val Gly Ile Phe 
    450                 455                 460                 


Leu Asp Tyr Glu Thr Gly Glu Ile Ser Phe Tyr Asn Ala Thr Asp Gly 
465                 470                 475                 480 


Ser His Ile Tyr Thr Phe Pro His Ala Ser Phe Ser Glu Pro Leu Tyr 
                485                 490                 495     


Pro Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys 
            500                 505                 510         


Pro Ile Pro Lys Glu Val Glu Ser Ser Pro Asp Pro Asp Leu Val Pro 
        515                 520                 525             


Asp His Ser Leu Glu Thr Pro Leu Thr Pro Gly Leu Ala Asn Glu Ser 
    530                 535                 540                 


Gly Glu Pro Gln Ala Glu Val Thr Ser Leu Leu Leu Pro Ala His Pro 
545                 550                 555                 560 


Gly Ala Glu Val Ser Pro Ser Ala Thr Thr Asn Gln Asn His Lys Leu 
                565                 570                 575     


Gln Ala Arg Thr Glu Ala Leu Tyr 
            580                 


<210>  1283
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTNL2__Homo_sapiens__NP_001291490

<400>  1283

Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Thr Met Lys Gln Ser Glu Asp Phe Arg Val Ile 
            20                  25                  30          


Gly Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Met His Val Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Glu Pro Ser Thr Pro Val Phe Val His Arg Asp Gly 
65                  70                  75                  80  


Val Glu Val Thr Glu Met Gln Met Glu Glu Tyr Arg Gly Trp Val Glu 
                85                  90                  95      


Trp Ile Glu Asn Gly Ile Ala Lys Gly Asn Val Ala Leu Lys Ile His 
            100                 105                 110         


Asn Ile Gln Pro Ser Asp Asn Gly Gln Tyr Trp Cys His Phe Gln Asp 
        115                 120                 125             


Gly Asn Tyr Cys Gly Glu Thr Ser Leu Leu Leu Lys Val Ala Gly Leu 
    130                 135                 140                 


Gly Ser Ala Pro Ser Ile His Met Glu Gly Pro Gly Glu Ser Gly Val 
145                 150                 155                 160 


Gln Leu Val Cys Thr Ala Arg Gly Trp Phe Pro Glu Pro Gln Val Tyr 
                165                 170                 175     


Trp Glu Asp Ile Arg Gly Glu Lys Leu Leu Ala Val Ser Glu His Arg 
            180                 185                 190         


Ile Gln Asp Lys Asp Gly Leu Phe Tyr Ala Glu Ala Thr Leu Val Val 
        195                 200                 205             


Arg Asn Ala Ser Ala Glu Ser Val Ser Cys Leu Val His Asn Pro Val 
    210                 215                 220                 


Leu Thr Glu Glu Lys Gly Ser Val Ile Ser Leu Pro Glu Lys Leu Gln 
225                 230                 235                 240 


Thr Glu Leu Ala Ser Leu Lys Val Asn Gly Pro Ser Gln Pro Ile Leu 
                245                 250                 255     


Val Arg Val Gly Glu Asp Ile Gln Leu Thr Cys Tyr Leu Ser Pro Lys 
            260                 265                 270         


Ala Asn Ala Gln Ser Met Glu Val Arg Trp Asp Arg Ser His Arg Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Met Asp Gly Asp His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Ala Glu Tyr Arg Gly Arg Thr Val Leu Val Ser Asp Ala Ile Asp 
305                 310                 315                 320 


Glu Gly Arg Leu Thr Leu Gln Ile Leu Ser Ala Arg Pro Ser Asp Asp 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Glu Lys Asp Asp Val Tyr Gln Glu Ala 
            340                 345                 350         


Ser Leu Asp Leu Lys Val Val Ser Leu Gly Ser Ser Pro Leu Ile Thr 
        355                 360                 365             


Val Glu Gly Gln Glu Asp Gly Glu Met Gln Pro Met Cys Ser Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Gln Pro His Val Pro Trp Arg Asp Met Glu Gly Lys 
385                 390                 395                 400 


Thr Ile Pro Ser Ser Ser Gln Ala Leu Thr Gln Gly Ser His Gly Leu 
                405                 410                 415     


Phe His Val Gln Thr Leu Leu Arg Val Thr Asn Ile Ser Ala Val Asp 
            420                 425                 430         


Val Thr Cys Ser Ile Ser Ile Pro Phe Leu Gly Glu Glu Lys Ile Ala 
        435                 440                 445             


Thr Phe Ser Leu Ser Glu Ser Arg Met Thr Phe Leu Trp Lys Thr Leu 
    450                 455                 460                 


Leu Val Trp Gly Leu Leu Leu Ala Val Ala Val Gly Leu Pro Arg Lys 
465                 470                 475                 480 


Arg Ser 
        


<210>  1284
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTRC__Homo_sapiens__NP_001243785

<400>  1284

Met Asp Pro Ala Glu Ala Val Leu Gln Glu Lys Ala Leu Lys Phe Met 
1               5                   10                  15      


Cys Ser Met Pro Arg Ser Leu Trp Leu Gly Cys Ser Ser Leu Ala Asp 
            20                  25                  30          


Ser Met Pro Ser Leu Arg Cys Leu Tyr Asn Pro Gly Thr Gly Ala Leu 
        35                  40                  45              


Thr Ala Phe Gln Thr Tyr Asn Ser Cys Ala Arg Leu Cys Leu Asn Gln 
    50                  55                  60                  


Glu Thr Val Cys Leu Ala Ser Thr Ala Met Lys Thr Glu Asn Cys Val 
65                  70                  75                  80  


Ala Lys Thr Lys Leu Ala Asn Gly Thr Ser Ser Met Ile Val Pro Lys 
                85                  90                  95      


Gln Arg Lys Leu Ser Ala Ser Tyr Glu Lys Glu Lys Glu Leu Cys Val 
            100                 105                 110         


Lys Tyr Phe Glu Gln Trp Ser Glu Ser Asp Gln Val Glu Phe Val Glu 
        115                 120                 125             


His Leu Ile Ser Gln Met Cys His Tyr Gln His Gly His Ile Asn Ser 
    130                 135                 140                 


Tyr Leu Lys Pro Met Leu Gln Arg Asp Phe Ile Thr Ala Leu Pro Ala 
145                 150                 155                 160 


Arg Gly Leu Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala 
                165                 170                 175     


Lys Ser Leu Cys Ala Ala Glu Leu Val Cys Lys Glu Trp Tyr Arg Val 
            180                 185                 190         


Thr Ser Asp Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Met Val Arg 
        195                 200                 205             


Thr Asp Ser Leu Trp Arg Gly Leu Ala Glu Arg Arg Gly Trp Gly Gln 
    210                 215                 220                 


Tyr Leu Phe Lys Asn Lys Pro Pro Asp Gly Asn Ala Pro Pro Asn Ser 
225                 230                 235                 240 


Phe Tyr Arg Ala Leu Tyr Pro Lys Ile Ile Gln Asp Ile Glu Thr Ile 
                245                 250                 255     


Glu Ser Asn Trp Arg Cys Gly Arg His Ser Leu Gln Arg Ile His Cys 
            260                 265                 270         


Arg Ser Glu Thr Ser Lys Gly Val Tyr Cys Leu Gln Tyr Asp Asp Gln 
        275                 280                 285             


Lys Ile Val Ser Gly Leu Arg Asp Asn Thr Ile Lys Ile Trp Asp Lys 
    290                 295                 300                 


Asn Thr Leu Glu Cys Lys Arg Ile Leu Thr Gly His Thr Gly Ser Val 
305                 310                 315                 320 


Leu Cys Leu Gln Tyr Asp Glu Arg Val Ile Ile Thr Gly Ser Ser Asp 
                325                 330                 335     


Ser Thr Val Arg Val Trp Asp Val Asn Thr Gly Glu Met Leu Asn Thr 
            340                 345                 350         


Leu Ile His His Cys Glu Ala Val Leu His Leu Arg Phe Asn Asn Gly 
        355                 360                 365             


Met Met Val Thr Cys Ser Lys Asp Arg Ser Ile Ala Val Trp Asp Met 
    370                 375                 380                 


Ala Ser Pro Thr Asp Ile Thr Leu Arg Arg Val Leu Val Gly His Arg 
385                 390                 395                 400 


Ala Ala Val Asn Val Val Asp Phe Asp Asp Lys Tyr Ile Val Ser Ala 
                405                 410                 415     


Ser Gly Asp Arg Thr Ile Lys Val Trp Asn Thr Ser Thr Cys Glu Phe 
            420                 425                 430         


Val Arg Thr Leu Asn Gly His Lys Arg Gly Ile Ala Cys Leu Gln Tyr 
        435                 440                 445             


Arg Asp Arg Leu Val Val Ser Gly Ser Ser Asp Asn Thr Ile Arg Leu 
    450                 455                 460                 


Trp Asp Ile Glu Cys Gly Ala Cys Leu Arg Val Leu Glu Gly His Glu 
465                 470                 475                 480 


Glu Leu Val Arg Cys Ile Arg Phe Asp Asn Lys Arg Ile Val Ser Gly 
                485                 490                 495     


Ala Tyr Asp Gly Lys Ile Lys Val Trp Asp Leu Val Ala Ala Leu Asp 
            500                 505                 510         


Pro Arg Ala Pro Ala Gly Thr Leu Cys Leu Arg Thr Leu Val Glu His 
        515                 520                 525             


Ser Gly Arg Val Phe Arg Leu Gln Phe Asp Glu Phe Gln Ile Val Ser 
    530                 535                 540                 


Ser Ser His Asp Asp Thr Ile Leu Ile Trp Asp Phe Leu Asn Asp Pro 
545                 550                 555                 560 


Ala Ala Gln Ala Glu Pro Pro Arg Ser Pro Ser Arg Thr Tyr Thr Tyr 
                565                 570                 575     


Ile Ser Arg 
            


<210>  1285
<211>  1050
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BUB1B__Homo_sapiens__NP_001202

<400>  1285

Met Ala Ala Val Lys Lys Glu Gly Gly Ala Leu Ser Glu Ala Met Ser 
1               5                   10                  15      


Leu Glu Gly Asp Glu Trp Glu Leu Ser Lys Glu Asn Val Gln Pro Leu 
            20                  25                  30          


Arg Gln Gly Arg Ile Met Ser Thr Leu Gln Gly Ala Leu Ala Gln Glu 
        35                  40                  45              


Ser Ala Cys Asn Asn Thr Leu Gln Gln Gln Lys Arg Ala Phe Glu Tyr 
    50                  55                  60                  


Glu Ile Arg Phe Tyr Thr Gly Asn Asp Pro Leu Asp Val Trp Asp Arg 
65                  70                  75                  80  


Tyr Ile Ser Trp Thr Glu Gln Asn Tyr Pro Gln Gly Gly Lys Glu Ser 
                85                  90                  95      


Asn Met Ser Thr Leu Leu Glu Arg Ala Val Glu Ala Leu Gln Gly Glu 
            100                 105                 110         


Lys Arg Tyr Tyr Ser Asp Pro Arg Phe Leu Asn Leu Trp Leu Lys Leu 
        115                 120                 125             


Gly Arg Leu Cys Asn Glu Pro Leu Asp Met Tyr Ser Tyr Leu His Asn 
    130                 135                 140                 


Gln Gly Ile Gly Val Ser Leu Ala Gln Phe Tyr Ile Ser Trp Ala Glu 
145                 150                 155                 160 


Glu Tyr Glu Ala Arg Glu Asn Phe Arg Lys Ala Asp Ala Ile Phe Gln 
                165                 170                 175     


Glu Gly Ile Gln Gln Lys Ala Glu Pro Leu Glu Arg Leu Gln Ser Gln 
            180                 185                 190         


His Arg Gln Phe Gln Ala Arg Val Ser Arg Gln Thr Leu Leu Ala Leu 
        195                 200                 205             


Glu Lys Glu Glu Glu Glu Glu Val Phe Glu Ser Ser Val Pro Gln Arg 
    210                 215                 220                 


Ser Thr Leu Ala Glu Leu Lys Ser Lys Gly Lys Lys Thr Ala Arg Ala 
225                 230                 235                 240 


Pro Ile Ile Arg Val Gly Gly Ala Leu Lys Ala Pro Ser Gln Asn Arg 
                245                 250                 255     


Gly Leu Gln Asn Pro Phe Pro Gln Gln Met Gln Asn Asn Ser Arg Ile 
            260                 265                 270         


Thr Val Phe Asp Glu Asn Ala Asp Glu Ala Ser Thr Ala Glu Leu Ser 
        275                 280                 285             


Lys Pro Thr Val Gln Pro Trp Ile Ala Pro Pro Met Pro Arg Ala Lys 
    290                 295                 300                 


Glu Asn Glu Leu Gln Ala Gly Pro Trp Asn Thr Gly Arg Ser Leu Glu 
305                 310                 315                 320 


His Arg Pro Arg Gly Asn Thr Ala Ser Leu Ile Ala Val Pro Ala Val 
                325                 330                 335     


Leu Pro Ser Phe Thr Pro Tyr Val Glu Glu Thr Ala Gln Gln Pro Val 
            340                 345                 350         


Met Thr Pro Cys Lys Ile Glu Pro Ser Ile Asn His Ile Leu Ser Thr 
        355                 360                 365             


Arg Lys Pro Gly Lys Glu Glu Gly Asp Pro Leu Gln Arg Val Gln Ser 
    370                 375                 380                 


His Gln Gln Ala Ser Glu Glu Lys Lys Glu Lys Met Met Tyr Cys Lys 
385                 390                 395                 400 


Glu Lys Ile Tyr Ala Gly Val Gly Glu Phe Ser Phe Glu Glu Ile Arg 
                405                 410                 415     


Ala Glu Val Phe Arg Lys Lys Leu Lys Glu Gln Arg Glu Ala Glu Leu 
            420                 425                 430         


Leu Thr Ser Ala Glu Lys Arg Ala Glu Met Gln Lys Gln Ile Glu Glu 
        435                 440                 445             


Met Glu Lys Lys Leu Lys Glu Ile Gln Thr Thr Gln Gln Glu Arg Thr 
    450                 455                 460                 


Gly Asp Gln Gln Glu Glu Thr Met Pro Thr Lys Glu Thr Thr Lys Leu 
465                 470                 475                 480 


Gln Ile Ala Ser Glu Ser Gln Lys Ile Pro Gly Met Thr Leu Ser Ser 
                485                 490                 495     


Ser Val Cys Gln Val Asn Cys Cys Ala Arg Glu Thr Ser Leu Ala Glu 
            500                 505                 510         


Asn Ile Trp Gln Glu Gln Pro His Ser Lys Gly Pro Ser Val Pro Phe 
        515                 520                 525             


Ser Ile Phe Asp Glu Phe Leu Leu Ser Glu Lys Lys Asn Lys Ser Pro 
    530                 535                 540                 


Pro Ala Asp Pro Pro Arg Val Leu Ala Gln Arg Arg Pro Leu Ala Val 
545                 550                 555                 560 


Leu Lys Thr Ser Glu Ser Ile Thr Ser Asn Glu Asp Val Ser Pro Asp 
                565                 570                 575     


Val Cys Asp Glu Phe Thr Gly Ile Glu Pro Leu Ser Glu Asp Ala Ile 
            580                 585                 590         


Ile Thr Gly Phe Arg Asn Val Thr Ile Cys Pro Asn Pro Glu Asp Thr 
        595                 600                 605             


Cys Asp Phe Ala Arg Ala Ala Arg Phe Val Ser Thr Pro Phe His Glu 
    610                 615                 620                 


Ile Met Ser Leu Lys Asp Leu Pro Ser Asp Pro Glu Arg Leu Leu Pro 
625                 630                 635                 640 


Glu Glu Asp Leu Asp Val Lys Thr Ser Glu Asp Gln Gln Thr Ala Cys 
                645                 650                 655     


Gly Thr Ile Tyr Ser Gln Thr Leu Ser Ile Lys Lys Leu Ser Pro Ile 
            660                 665                 670         


Ile Glu Asp Ser Arg Glu Ala Thr His Ser Ser Gly Phe Ser Gly Ser 
        675                 680                 685             


Ser Ala Ser Val Ala Ser Thr Ser Ser Ile Lys Cys Leu Gln Ile Pro 
    690                 695                 700                 


Glu Lys Leu Glu Leu Thr Asn Glu Thr Ser Glu Asn Pro Thr Gln Ser 
705                 710                 715                 720 


Pro Trp Cys Ser Gln Tyr Arg Arg Gln Leu Leu Lys Ser Leu Pro Glu 
                725                 730                 735     


Leu Ser Ala Ser Ala Glu Leu Cys Ile Glu Asp Arg Pro Met Pro Lys 
            740                 745                 750         


Leu Glu Ile Glu Lys Glu Ile Glu Leu Gly Asn Glu Asp Tyr Cys Ile 
        755                 760                 765             


Lys Arg Glu Tyr Leu Ile Cys Glu Asp Tyr Lys Leu Phe Trp Val Ala 
    770                 775                 780                 


Pro Arg Asn Ser Ala Glu Leu Thr Val Ile Lys Val Ser Ser Gln Pro 
785                 790                 795                 800 


Val Pro Trp Asp Phe Tyr Ile Asn Leu Lys Leu Lys Glu Arg Leu Asn 
                805                 810                 815     


Glu Asp Phe Asp His Phe Cys Ser Cys Tyr Gln Tyr Gln Asp Gly Cys 
            820                 825                 830         


Ile Val Trp His Gln Tyr Ile Asn Cys Phe Thr Leu Gln Asp Leu Leu 
        835                 840                 845             


Gln His Ser Glu Tyr Ile Thr His Glu Ile Thr Val Leu Ile Ile Tyr 
    850                 855                 860                 


Asn Leu Leu Thr Ile Val Glu Met Leu His Lys Ala Glu Ile Val His 
865                 870                 875                 880 


Gly Asp Leu Ser Pro Arg Cys Leu Ile Leu Arg Asn Arg Ile His Asp 
                885                 890                 895     


Pro Tyr Asp Cys Asn Lys Asn Asn Gln Ala Leu Lys Ile Val Asp Phe 
            900                 905                 910         


Ser Tyr Ser Val Asp Leu Arg Val Gln Leu Asp Val Phe Thr Leu Ser 
        915                 920                 925             


Gly Phe Arg Thr Val Gln Ile Leu Glu Gly Gln Lys Ile Leu Ala Asn 
    930                 935                 940                 


Cys Ser Ser Pro Tyr Gln Val Asp Leu Phe Gly Ile Ala Asp Leu Ala 
945                 950                 955                 960 


His Leu Leu Leu Phe Lys Glu His Leu Gln Val Phe Trp Asp Gly Ser 
                965                 970                 975     


Phe Trp Lys Leu Ser Gln Asn Ile Ser Glu Leu Lys Asp Gly Glu Leu 
            980                 985                 990         


Trp Asn Lys Phe Phe Val Arg Ile  Leu Asn Ala Asn Asp  Glu Ala Thr 
        995                 1000                 1005             


Val Ser  Val Leu Gly Glu Leu  Ala Ala Glu Met Asn  Gly Val Phe 
    1010                 1015                 1020             


Asp Thr  Thr Phe Gln Ser His  Leu Asn Lys Ala Leu  Trp Lys Val 
    1025                 1030                 1035             


Gly Lys  Leu Thr Ser Pro Gly  Ala Leu Leu Phe Gln  
    1040                 1045                 1050 


<210>  1286
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BUB1__Homo_sapiens__NP_001265545

<400>  1286

Met Asp Thr Pro Glu Asn Val Leu Gln Tyr Ile Gln Trp Val Glu Glu 
1               5                   10                  15      


Asn Phe Pro Glu Asn Lys Glu Tyr Leu Ile Thr Leu Leu Glu His Leu 
            20                  25                  30          


Met Lys Glu Phe Leu Asp Lys Lys Lys Tyr His Asn Asp Pro Arg Phe 
        35                  40                  45              


Ile Ser Tyr Cys Leu Lys Phe Ala Glu Tyr Asn Ser Asp Leu His Gln 
    50                  55                  60                  


Phe Phe Glu Phe Leu Tyr Asn His Gly Ile Gly Thr Leu Ser Ser Pro 
65                  70                  75                  80  


Leu Tyr Ile Ala Trp Ala Gly His Leu Glu Ala Gln Gly Glu Leu Gln 
                85                  90                  95      


His Ala Ser Ala Val Leu Gln Arg Gly Ile Gln Asn Gln Ala Glu Pro 
            100                 105                 110         


Arg Glu Phe Leu Gln Gln Gln Tyr Arg Leu Phe Gln Thr Arg Leu Thr 
        115                 120                 125             


Glu Thr His Leu Pro Ala Gln Ala Arg Thr Ser Glu Pro Leu His Asn 
    130                 135                 140                 


Val Gln Val Leu Asn Gln Met Ile Thr Ser Lys Ser Asn Pro Gly Asn 
145                 150                 155                 160 


Asn Met Ala Cys Ile Ser Lys Asn Gln Gly Ser Glu Leu Ser Gly Val 
                165                 170                 175     


Ile Ser Ser Ala Cys Asp Lys Glu Ser Asn Met Glu Arg Arg Val Ile 
            180                 185                 190         


Thr Ile Ser Lys Ser Glu Tyr Ser Val His Ser Ser Leu Ala Ser Lys 
        195                 200                 205             


Val Asp Val Glu Gln Val Val Met Tyr Cys Lys Glu Lys Leu Ile Arg 
    210                 215                 220                 


Gly Glu Ser Glu Phe Ser Phe Glu Glu Leu Arg Ala Gln Lys Tyr Asn 
225                 230                 235                 240 


Gln Arg Arg Lys His Glu Gln Trp Val Asn Glu Asp Arg His Tyr Met 
                245                 250                 255     


Lys Arg Lys Glu Ala Asn Ala Phe Glu Glu Gln Leu Leu Lys Gln Lys 
            260                 265                 270         


Met Asp Glu Leu His Lys Lys Leu His Gln Val Val Glu Thr Ser His 
        275                 280                 285             


Glu Asp Leu Pro Ala Ser Gln Glu Arg Ser Glu Val Asn Pro Ala Arg 
    290                 295                 300                 


Met Gly Pro Ser Val Gly Ser Gln Gln Glu Leu Arg Ala Pro Cys Leu 
305                 310                 315                 320 


Pro Val Thr Tyr Gln Gln Thr Pro Val Asn Met Glu Lys Asn Pro Arg 
                325                 330                 335     


Glu Ala Pro Pro Val Val Pro Pro Leu Ala Asn Ala Ile Ser Ala Ala 
            340                 345                 350         


Leu Val Ser Pro Ala Thr Ser Gln Ser Ile Ala Pro Pro Val Pro Leu 
        355                 360                 365             


Lys Ala Gln Thr Val Thr Asp Ser Met Phe Ala Val Ala Ser Lys Asp 
    370                 375                 380                 


Ala Gly Cys Val Asn Lys Ser Thr His Glu Phe Lys Pro Gln Ser Gly 
385                 390                 395                 400 


Ala Glu Ile Lys Glu Gly Cys Glu Thr His Lys Val Ala Asn Thr Ser 
                405                 410                 415     


Ser Phe His Thr Thr Pro Asn Thr Ser Leu Gly Met Val Gln Ala Thr 
            420                 425                 430         


Pro Ser Lys Val Gln Pro Ser Pro Thr Val His Thr Lys Glu Ala Leu 
        435                 440                 445             


Gly Phe Ile Met Asn Met Phe Gln Ala Pro Thr Leu Pro Asp Ile Ser 
    450                 455                 460                 


Asp Asp Lys Asp Glu Trp Gln Ser Leu Asp Gln Asn Glu Asp Ala Phe 
465                 470                 475                 480 


Glu Ala Gln Phe Gln Lys Asn Val Arg Ser Ser Gly Ala Trp Gly Val 
                485                 490                 495     


Asn Lys Ile Ile Ser Ser Leu Ser Ser Ala Phe His Val Phe Glu Asp 
            500                 505                 510         


Gly Asn Lys Glu Asn Tyr Gly Leu Pro Gln Pro Lys Asn Lys Pro Thr 
        515                 520                 525             


Gly Ala Arg Thr Phe Gly Glu Arg Ser Val Ser Arg Leu Pro Ser Lys 
    530                 535                 540                 


Pro Lys Glu Glu Val Pro His Ala Glu Glu Phe Leu Asp Asp Ser Thr 
545                 550                 555                 560 


Val Trp Gly Ile Arg Cys Asn Lys Thr Leu Ala Pro Ser Pro Lys Ser 
                565                 570                 575     


Pro Gly Asp Phe Thr Ser Ala Ala Gln Leu Ala Ser Thr Pro Phe His 
            580                 585                 590         


Lys Leu Pro Val Glu Ser Val His Ile Leu Glu Asp Lys Glu Asn Val 
        595                 600                 605             


Val Ala Lys Gln Cys Thr Gln Ala Thr Leu Asp Ser Cys Glu Glu Asn 
    610                 615                 620                 


Met Val Val Pro Ser Arg Asp Gly Lys Phe Ser Pro Ile Gln Glu Lys 
625                 630                 635                 640 


Ser Pro Lys Gln Ala Leu Ser Ser His Met Tyr Ser Ala Ser Leu Leu 
                645                 650                 655     


Arg Leu Ser Gln Pro Ala Ala Gly Gly Val Leu Thr Cys Glu Ala Glu 
            660                 665                 670         


Leu Gly Val Glu Ala Cys Arg Leu Thr Asp Thr Asp Ala Ala Ile Ala 
        675                 680                 685             


Glu Asp Pro Pro Asp Ala Ile Ala Gly Leu Gln Ala Glu Trp Met Gln 
    690                 695                 700                 


Met Ser Ser Leu Gly Thr Val Asp Ala Pro Asn Phe Ile Val Gly Asn 
705                 710                 715                 720 


Pro Trp Asp Asp Lys Leu Ile Phe Lys Leu Leu Ser Gly Leu Ser Lys 
                725                 730                 735     


Pro Val Ser Ser Tyr Pro Asn Thr Phe Glu Trp Gln Cys Lys Leu Pro 
            740                 745                 750         


Ala Ile Lys Pro Lys Thr Glu Phe Gln Leu Gly Ser Lys Leu Val Tyr 
        755                 760                 765             


Val His His Leu Leu Gly Glu Gly Ala Phe Ala Gln Val Tyr Glu Ala 
    770                 775                 780                 


Thr Gln Gly Asp Leu Asn Asp Ala Lys Asn Lys Gln Lys Phe Val Leu 
785                 790                 795                 800 


Lys Val Gln Lys Pro Ala Asn Pro Trp Glu Phe Tyr Ile Gly Thr Gln 
                805                 810                 815     


Leu Met Glu Arg Leu Lys Pro Ser Met Gln His Met Phe Met Lys Phe 
            820                 825                 830         


Tyr Ser Ala His Leu Phe Gln Asn Gly Ser Val Leu Val Gly Glu Leu 
        835                 840                 845             


Tyr Ser Tyr Gly Thr Leu Leu Asn Ala Ile Asn Leu Tyr Lys Asn Thr 
    850                 855                 860                 


Pro Glu Lys Val Met Pro Gln Gly Leu Val Ile Ser Phe Ala Met Arg 
865                 870                 875                 880 


Met Leu Tyr Met Ile Glu Gln Val His Asp Cys Glu Ile Ile His Gly 
                885                 890                 895     


Asp Ile Lys Pro Asp Asn Phe Ile Leu Gly Asn Gly Phe Leu Glu Gln 
            900                 905                 910         


Asp Asp Glu Asp Asp Leu Ser Ala Gly Leu Ala Leu Ile Asp Leu Gly 
        915                 920                 925             


Gln Ser Ile Asp Met Lys Leu Phe Pro Lys Gly Thr Ile Phe Thr Ala 
    930                 935                 940                 


Lys Cys Glu Thr Ser Gly Phe Gln Cys Val Glu Met Leu Ser Asn Lys 
945                 950                 955                 960 


Pro Trp Asn Tyr Gln Ile Asp Tyr Phe Gly Val Ala Ala Thr Val Tyr 
                965                 970                 975     


Cys Met Leu Phe Gly Thr Tyr Met Lys Val Lys Asn Glu Gly Gly Glu 
            980                 985                 990         


Cys Lys Pro Glu Gly Leu Phe Arg  Arg Leu Pro His Leu  Asp Met Trp 
        995                 1000                 1005             


Asn Glu  Phe Phe His Val Met  Leu Asn Ile Pro Asp  Cys His His 
    1010                 1015                 1020             


Leu Pro  Ser Leu Asp Leu Leu  Arg Gln Lys Leu Lys  Lys Val Phe 
    1025                 1030                 1035             


Gln Gln  His Tyr Thr Asn Lys  Ile Arg Ala Leu Arg  Asn Arg Leu 
    1040                 1045                 1050             


Ile Val  Leu Leu Leu Glu Cys  Lys Arg Ser Arg Lys  
    1055                 1060                 1065 


<210>  1287
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BUB3__Homo_sapiens__NP_001007794

<400>  1287

Met Thr Gly Ser Asn Glu Phe Lys Leu Asn Gln Pro Pro Glu Asp Gly 
1               5                   10                  15      


Ile Ser Ser Val Lys Phe Ser Pro Asn Thr Ser Gln Phe Leu Leu Val 
            20                  25                  30          


Ser Ser Trp Asp Thr Ser Val Arg Leu Tyr Asp Val Pro Ala Asn Ser 
        35                  40                  45              


Met Arg Leu Lys Tyr Gln His Thr Gly Ala Val Leu Asp Cys Ala Phe 
    50                  55                  60                  


Tyr Asp Pro Thr His Ala Trp Ser Gly Gly Leu Asp His Gln Leu Lys 
65                  70                  75                  80  


Met His Asp Leu Asn Thr Asp Gln Glu Asn Leu Val Gly Thr His Asp 
                85                  90                  95      


Ala Pro Ile Arg Cys Val Glu Tyr Cys Pro Glu Val Asn Val Met Val 
            100                 105                 110         


Thr Gly Ser Trp Asp Gln Thr Val Lys Leu Trp Asp Pro Arg Thr Pro 
        115                 120                 125             


Cys Asn Ala Gly Thr Phe Ser Gln Pro Glu Lys Val Tyr Thr Leu Ser 
    130                 135                 140                 


Val Ser Gly Asp Arg Leu Ile Val Gly Thr Ala Gly Arg Arg Val Leu 
145                 150                 155                 160 


Val Trp Asp Leu Arg Asn Met Gly Tyr Val Gln Gln Arg Arg Glu Ser 
                165                 170                 175     


Ser Leu Lys Tyr Gln Thr Arg Cys Ile Arg Ala Phe Pro Asn Lys Gln 
            180                 185                 190         


Gly Tyr Val Leu Ser Ser Ile Glu Gly Arg Val Ala Val Glu Tyr Leu 
        195                 200                 205             


Asp Pro Ser Pro Glu Val Gln Lys Lys Lys Tyr Ala Phe Lys Cys His 
    210                 215                 220                 


Arg Leu Lys Glu Asn Asn Ile Glu Gln Ile Tyr Pro Val Asn Ala Ile 
225                 230                 235                 240 


Ser Phe His Asn Ile His Asn Thr Phe Ala Thr Gly Gly Ser Asp Gly 
                245                 250                 255     


Phe Val Asn Ile Trp Asp Pro Phe Asn Lys Lys Arg Leu Cys Gln Phe 
            260                 265                 270         


His Arg Tyr Pro Thr Ser Ile Ala Ser Leu Ala Phe Ser Asn Asp Gly 
        275                 280                 285             


Thr Thr Leu Ala Ile Ala Ser Ser Tyr Met Tyr Glu Met Asp Asp Thr 
    290                 295                 300                 


Glu His Pro Glu Asp Gly Ile Phe Ile Arg Gln Val Thr Asp Ala Glu 
305                 310                 315                 320 


Thr Lys Pro Lys Ser Thr 
                325     


<210>  1288
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BUD13__Homo_sapiens__NP_001153208

<400>  1288

Met Ala Ala Ala Pro Pro Leu Ser Lys Ala Glu Tyr Leu Lys Arg Tyr 
1               5                   10                  15      


Leu Ser Gly Ala Asp Ala Gly Val Asp Arg Gly Ser Glu Ser Gly Arg 
            20                  25                  30          


Lys Arg Arg Lys Lys Arg Pro Lys Pro Gly Gly Ala Gly Gly Lys Gly 
        35                  40                  45              


Met Arg Ile Val Asp Asp Asp Val Ser Trp Thr Ala Ile Ser Thr Thr 
    50                  55                  60                  


Lys Leu Glu Lys Glu Glu Glu Glu Asp Asp Gly Asp Leu Pro Val Val 
65                  70                  75                  80  


Ala Glu Phe Val Asp Glu Arg Pro Glu Glu Val Lys Gln Met Glu Ala 
                85                  90                  95      


Phe Arg Ser Ser Ala Lys Trp Lys Leu Leu Gly Gly His Asn Glu Asp 
            100                 105                 110         


Leu Pro Ser Asn Arg His Phe Arg His Asp Thr Pro Asp Ser Ser Pro 
        115                 120                 125             


Arg Arg Val Arg His Gly Thr Pro Asp Pro Ser Pro Arg Lys Asp Arg 
    130                 135                 140                 


His Asp Thr Pro Asp Pro Ser Pro Arg Arg Ala Arg His Asp Thr Pro 
145                 150                 155                 160 


Asp Pro Ser Pro Leu Arg Gly Ala Arg His Asp Ser Asp Thr Ser Pro 
                165                 170                 175     


Pro Arg Arg Ile Arg His Asp Ser Ser Asp Thr Ser Pro Pro Arg Arg 
            180                 185                 190         


Ala Arg His Asp Ser Pro Asp Pro Ser Pro Pro Arg Arg Pro Gln His 
        195                 200                 205             


Asn Ser Ser Gly Asp Cys Gln Lys Ala Thr Asp Ser Asp Leu Ser Ser 
    210                 215                 220                 


Pro Arg His Lys Gln Ser Pro Gly His Gln Asp Ser Asp Ser Asp Leu 
225                 230                 235                 240 


Ser Pro Pro Arg Asn Arg Pro Arg His Arg Ser Ser Asp Ser Asp Leu 
                245                 250                 255     


Ser Pro Pro Arg Arg Arg Gln Arg Thr Lys Ser Ser Asp Ser Asp Leu 
            260                 265                 270         


Ser Pro Pro Arg Arg Ser Gln Pro Pro Gly Lys Lys Ala Ala His Met 
        275                 280                 285             


Tyr Ser Gly Ala Lys Thr Gly Leu Val Leu Thr Asp Ile Gln Arg Glu 
    290                 295                 300                 


Gln Gln Glu Leu Lys Glu Gln Asp Gln Glu Thr Met Ala Phe Glu Ala 
305                 310                 315                 320 


Glu Phe Gln Tyr Ala Glu Thr Val Phe Arg Asp Lys Ser Gly Arg Lys 
                325                 330                 335     


Arg Asn Leu Lys Leu Glu Arg Leu Glu Gln Arg Arg Lys Ala Glu Lys 
            340                 345                 350         


Asp Ser Glu Arg Asp Glu Leu Tyr Ala Gln Trp Gly Lys Gly Leu Ala 
        355                 360                 365             


Gln Ser Arg Gln Gln Gln Gln Asn Val Glu Asp Ala Met Lys Glu Met 
    370                 375                 380                 


Gln Lys Pro Leu Ala Arg Tyr Ile Asp Asp Glu Asp Leu Asp Arg Met 
385                 390                 395                 400 


Leu Arg Glu Gln Glu Arg Glu Gly Asp Pro Met Ala Asn Phe Ile Lys 
                405                 410                 415     


Lys Asn Lys Ala Lys Glu Asn Lys Asn Lys Lys Val Arg Pro Arg Tyr 
            420                 425                 430         


Ser Gly Pro Ala Pro Pro Pro Asn Arg Phe Asn Ile Trp Pro Gly Tyr 
        435                 440                 445             


Arg Trp Asp Gly Val Asp Arg Ser Asn Gly Phe Glu Gln Lys Arg Phe 
    450                 455                 460                 


Ala Arg Leu Ala Ser Lys Lys Ala Val Glu Glu Leu Ala Tyr Lys Trp 
465                 470                 475                 480 


Ser Val Glu Asp Met 
                485 


<210>  1289
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BUD31__Homo_sapiens__NP_003901

<400>  1289

Met Pro Lys Val Lys Arg Ser Arg Lys Ala Pro Pro Asp Gly Trp Glu 
1               5                   10                  15      


Leu Ile Glu Pro Thr Leu Asp Glu Leu Asp Gln Lys Met Arg Glu Ala 
            20                  25                  30          


Glu Thr Glu Pro His Glu Gly Lys Arg Lys Val Glu Ser Leu Trp Pro 
        35                  40                  45              


Ile Phe Arg Ile His His Gln Lys Thr Arg Tyr Ile Phe Asp Leu Phe 
    50                  55                  60                  


Tyr Lys Arg Lys Ala Ile Ser Arg Glu Leu Tyr Glu Tyr Cys Ile Lys 
65                  70                  75                  80  


Glu Gly Tyr Ala Asp Lys Asn Leu Ile Ala Lys Trp Lys Lys Gln Gly 
                85                  90                  95      


Tyr Glu Asn Leu Cys Cys Leu Arg Cys Ile Gln Thr Arg Asp Thr Asn 
            100                 105                 110         


Phe Gly Thr Asn Cys Ile Cys Arg Val Pro Lys Ser Lys Leu Glu Val 
        115                 120                 125             


Gly Arg Ile Ile Glu Cys Thr His Cys Gly Cys Arg Gly Cys Ser Gly 
    130                 135                 140                 


<210>  1290
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BVES__Homo_sapiens__XP_011533700

<400>  1290

Met Asn Tyr Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala Ile Gly 
1               5                   10                  15      


Phe Thr Pro Glu Leu Glu Ser Ile Ile Pro Val Pro Ser Asn Lys Thr 
            20                  25                  30          


Thr Cys Glu Asn Trp Arg Glu Ile His His Leu Val Phe His Val Ala 
        35                  40                  45              


Asn Ile Cys Phe Ala Val Gly Leu Val Ile Pro Thr Thr Leu His Leu 
    50                  55                  60                  


His Met Ile Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr 
65                  70                  75                  80  


Ile Val Trp Ala Thr Leu Tyr Arg Cys Ala Leu Asp Ile Met Ile Trp 
                85                  90                  95      


Asn Ser Val Phe Leu Gly Val Asn Ile Leu His Leu Ser Tyr Leu Leu 
            100                 105                 110         


Tyr Lys Lys Arg Pro Val Lys Ile Glu Lys Glu Leu Ser Gly Met Tyr 
        115                 120                 125             


Arg Arg Leu Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg 
    130                 135                 140                 


Leu Thr Gly Gln Phe Cys Met Ile Gln Thr Leu Lys Lys Gly Gln Thr 
145                 150                 155                 160 


Tyr Ala Ala Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser Ile Leu 
                165                 170                 175     


Leu Lys Gly Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn 
            180                 185                 190         


Ile Tyr Pro Cys Ala Phe Ile Asp Ser Pro Glu Phe Arg Ser Thr Gln 
        195                 200                 205             


Met His Lys Gly Glu Lys Phe Gln Val Thr Ile Ile Ala Asp Asp Asn 
    210                 215                 220                 


Cys Arg Phe Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu 
225                 230                 235                 240 


Ser Glu Pro Phe Leu Tyr Glu Ile Phe Arg Tyr Leu Ile Gly Lys Asp 
                245                 250                 255     


Ile Thr Asn Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys 
            260                 265                 270         


Lys Ala Lys Lys Leu Glu His Gln Leu Ser Leu Cys Thr Gln Ile Ser 
        275                 280                 285             


Met Leu Glu Met Arg Asn Ser Ile Ala Ser Ser Ser Asp Ser Asp Asp 
    290                 295                 300                 


Gly Leu His Gln Phe Leu Arg Gly Thr Ser Ser Met Ser Ser Leu His 
305                 310                 315                 320 


Val Ser Ser Pro His Gln Arg Ala Ser Ala Lys Met Lys Pro Ile Glu 
                325                 330                 335     


Glu Gly Ala Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn 
            340                 345                 350         


Thr Leu Lys Val His Gln Leu Pro 
        355                 360 


<210>  1291
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BYSL__Homo_sapiens__NP_004044

<400>  1291

Met Pro Lys Phe Lys Ala Ala Arg Gly Val Gly Gly Gln Glu Lys His 
1               5                   10                  15      


Ala Pro Leu Ala Asp Gln Ile Leu Ala Gly Asn Ala Val Arg Ala Gly 
            20                  25                  30          


Val Arg Glu Lys Arg Arg Gly Arg Gly Thr Gly Glu Ala Glu Glu Glu 
        35                  40                  45              


Tyr Val Gly Pro Arg Leu Ser Arg Arg Ile Leu Gln Gln Ala Arg Gln 
    50                  55                  60                  


Gln Gln Glu Glu Leu Glu Ala Glu His Gly Thr Gly Asp Lys Pro Ala 
65                  70                  75                  80  


Ala Pro Arg Glu Arg Thr Thr Arg Leu Gly Pro Arg Met Pro Gln Asp 
                85                  90                  95      


Gly Ser Asp Asp Glu Asp Glu Glu Trp Pro Thr Leu Glu Lys Ala Ala 
            100                 105                 110         


Thr Met Thr Ala Ala Gly His His Ala Glu Val Val Val Asp Pro Glu 
        115                 120                 125             


Asp Glu Arg Ala Ile Glu Met Phe Met Asn Lys Asn Pro Pro Ala Arg 
    130                 135                 140                 


Arg Thr Leu Ala Asp Ile Ile Met Glu Lys Leu Thr Glu Lys Gln Thr 
145                 150                 155                 160 


Glu Val Glu Thr Val Met Ser Glu Val Ser Gly Phe Pro Met Pro Gln 
                165                 170                 175     


Leu Asp Pro Arg Val Leu Glu Val Tyr Arg Gly Val Arg Glu Val Leu 
            180                 185                 190         


Ser Lys Tyr Arg Ser Gly Lys Leu Pro Lys Ala Phe Lys Ile Ile Pro 
        195                 200                 205             


Ala Leu Ser Asn Trp Glu Gln Ile Leu Tyr Val Thr Glu Pro Glu Ala 
    210                 215                 220                 


Trp Thr Ala Ala Ala Met Tyr Gln Ala Thr Arg Ile Phe Ala Ser Asn 
225                 230                 235                 240 


Leu Lys Glu Arg Met Ala Gln Arg Phe Tyr Asn Leu Val Leu Leu Pro 
                245                 250                 255     


Arg Val Arg Asp Asp Val Ala Glu Tyr Lys Arg Leu Asn Phe His Leu 
            260                 265                 270         


Tyr Met Ala Leu Lys Lys Ala Leu Phe Lys Pro Gly Ala Trp Phe Lys 
        275                 280                 285             


Gly Ile Leu Ile Pro Leu Cys Glu Ser Gly Thr Cys Thr Leu Arg Glu 
    290                 295                 300                 


Ala Ile Ile Val Gly Ser Ile Ile Thr Lys Cys Ser Ile Pro Val Leu 
305                 310                 315                 320 


His Ser Ser Ala Ala Met Leu Lys Ile Ala Glu Met Glu Tyr Ser Gly 
                325                 330                 335     


Ala Asn Ser Ile Phe Leu Arg Leu Leu Leu Asp Lys Lys Tyr Ala Leu 
            340                 345                 350         


Pro Tyr Arg Val Leu Asp Ala Leu Val Phe His Phe Leu Gly Phe Arg 
        355                 360                 365             


Thr Glu Lys Arg Glu Leu Pro Val Leu Trp His Gln Cys Leu Leu Thr 
    370                 375                 380                 


Leu Val Gln Arg Tyr Lys Ala Asp Leu Ala Thr Asp Gln Lys Glu Ala 
385                 390                 395                 400 


Leu Leu Glu Leu Leu Arg Leu Gln Pro His Pro Gln Leu Ser Pro Glu 
                405                 410                 415     


Ile Arg Arg Glu Leu Gln Ser Ala Val Pro Arg Asp Val Glu Asp Val 
            420                 425                 430         


Pro Ile Thr Val Glu 
        435         


<210>  1292
<211>  1848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BZRAP1__Homo_sapiens__NP_001248764

<400>  1292

Met Glu Gln Leu Thr Thr Leu Pro Arg Pro Gly Asp Pro Gly Ala Met 
1               5                   10                  15      


Glu Pro Trp Ala Leu Pro Thr Trp His Ser Trp Thr Pro Gly Arg Gly 
            20                  25                  30          


Gly Glu Pro Ser Ser Ala Ala Pro Ser Ile Ala Asp Thr Pro Pro Ala 
        35                  40                  45              


Ala Leu Gln Leu Gln Glu Leu Arg Ser Glu Glu Ser Ser Lys Pro Lys 
    50                  55                  60                  


Gly Asp Gly Ser Ser Arg Pro Val Gly Gly Thr Asp Pro Glu Gly Ala 
65                  70                  75                  80  


Glu Ala Cys Leu Pro Ser Leu Gly Gln Gln Ala Ser Ser Ser Gly Pro 
                85                  90                  95      


Ala Cys Gln Arg Pro Glu Asp Glu Glu Val Glu Ala Phe Leu Lys Ala 
            100                 105                 110         


Lys Leu Asn Met Ser Phe Gly Asp Arg Pro Asn Leu Glu Leu Leu Arg 
        115                 120                 125             


Ala Leu Gly Glu Leu Arg Gln Arg Cys Ala Ile Leu Lys Glu Glu Asn 
    130                 135                 140                 


Gln Met Leu Arg Lys Ser Ser Phe Pro Glu Thr Glu Glu Lys Val Arg 
145                 150                 155                 160 


Arg Leu Lys Arg Lys Asn Ala Glu Leu Ala Val Ile Ala Lys Arg Leu 
                165                 170                 175     


Glu Glu Arg Ala Arg Lys Leu Gln Glu Thr Asn Leu Arg Val Val Ser 
            180                 185                 190         


Ala Pro Leu Pro Arg Pro Gly Thr Ser Leu Glu Leu Cys Arg Lys Ala 
        195                 200                 205             


Leu Ala Arg Gln Arg Ala Arg Asp Leu Ser Glu Thr Ala Ser Ala Leu 
    210                 215                 220                 


Leu Ala Lys Asp Lys Gln Ile Ala Ala Leu Gln Arg Glu Cys Arg Glu 
225                 230                 235                 240 


Leu Gln Ala Arg Leu Thr Leu Val Gly Lys Glu Gly Pro Gln Trp Leu 
                245                 250                 255     


His Val Arg Asp Phe Asp Arg Leu Leu Arg Glu Ser Gln Arg Glu Val 
            260                 265                 270         


Leu Arg Leu Gln Arg Gln Ile Ala Leu Arg Asn Gln Arg Glu Thr Leu 
        275                 280                 285             


Pro Leu Pro Pro Ser Trp Pro Pro Gly Pro Ala Leu Gln Ala Arg Ala 
    290                 295                 300                 


Gly Ala Pro Ala Pro Gly Ala Pro Gly Glu Ala Thr Pro Gln Glu Asp 
305                 310                 315                 320 


Ala Asp Asn Leu Pro Val Ile Leu Gly Glu Pro Glu Lys Glu Gln Arg 
                325                 330                 335     


Val Gln Gln Leu Glu Ser Glu Leu Ser Lys Lys Arg Lys Lys Cys Glu 
            340                 345                 350         


Ser Leu Glu Gln Glu Ala Arg Lys Lys Gln Arg Arg Cys Glu Glu Leu 
        355                 360                 365             


Glu Leu Gln Leu Arg Gln Ala Gln Asn Glu Asn Ala Arg Leu Val Glu 
    370                 375                 380                 


Glu Asn Ser Arg Leu Ser Gly Arg Ala Thr Glu Lys Glu Gln Val Glu 
385                 390                 395                 400 


Trp Glu Asn Ala Glu Leu Arg Gly Gln Leu Leu Gly Val Thr Gln Glu 
                405                 410                 415     


Arg Asp Ser Ala Leu Arg Lys Ser Gln Gly Leu Gln Ser Lys Leu Glu 
            420                 425                 430         


Ser Leu Glu Gln Val Leu Lys His Met Arg Glu Val Ala Gln Arg Arg 
        435                 440                 445             


Gln Gln Leu Glu Val Glu His Glu Gln Ala Arg Leu Ser Leu Arg Glu 
    450                 455                 460                 


Lys Gln Glu Glu Val Arg Arg Leu Gln Gln Ala Gln Ala Glu Ala Gln 
465                 470                 475                 480 


Arg Glu His Glu Gly Ala Val Gln Leu Leu Glu Ser Thr Leu Asp Ser 
                485                 490                 495     


Met Gln Ala Arg Val Arg Glu Leu Glu Glu Gln Cys Arg Ser Gln Thr 
            500                 505                 510         


Glu Gln Phe Ser Leu Leu Ala Gln Glu Leu Gln Ala Phe Arg Leu His 
        515                 520                 525             


Pro Gly Pro Leu Asp Leu Leu Thr Ser Ala Leu Asp Cys Gly Ser Leu 
    530                 535                 540                 


Gly Asp Cys Pro Pro Pro Pro Cys Cys Cys Ser Ile Pro Gln Pro Cys 
545                 550                 555                 560 


Arg Gly Ser Gly Pro Lys Asp Leu Asp Leu Pro Pro Gly Ser Pro Gly 
                565                 570                 575     


Arg Cys Thr Pro Lys Ser Ser Glu Pro Ala Pro Ala Thr Leu Thr Gly 
            580                 585                 590         


Val Pro Arg Arg Thr Ala Lys Lys Ala Glu Ser Leu Ser Asn Ser Ser 
        595                 600                 605             


His Ser Glu Ser Ile His Asn Ser Pro Lys Ser Cys Pro Thr Pro Glu 
    610                 615                 620                 


Val Asp Thr Ala Ser Glu Val Glu Glu Leu Glu Ala Asp Ser Val Ser 
625                 630                 635                 640 


Leu Leu Pro Ala Ala Pro Glu Gly Ser Arg Gly Gly Ala Arg Ile Gln 
                645                 650                 655     


Val Phe Leu Ala Arg Tyr Ser Tyr Asn Pro Phe Glu Gly Pro Asn Glu 
            660                 665                 670         


Asn Pro Glu Ala Glu Leu Pro Leu Thr Ala Gly Glu Tyr Ile Tyr Ile 
        675                 680                 685             


Tyr Gly Asn Met Asp Glu Asp Gly Phe Phe Glu Gly Glu Leu Met Asp 
    690                 695                 700                 


Gly Arg Arg Gly Leu Val Pro Ser Asn Phe Val Glu Arg Val Ser Asp 
705                 710                 715                 720 


Asp Asp Leu Leu Thr Ser Leu Pro Pro Glu Leu Ala Asp Leu Ser His 
                725                 730                 735     


Ser Ser Gly Pro Glu Leu Ser Phe Leu Ser Val Gly Gly Gly Gly Ser 
            740                 745                 750         


Ser Ser Gly Gly Gln Ser Ser Val Gly Arg Ser Gln Pro Arg Pro Glu 
        755                 760                 765             


Glu Glu Asp Ala Gly Asp Glu Leu Ser Leu Ser Pro Ser Pro Glu Gly 
    770                 775                 780                 


Leu Gly Glu Pro Pro Ala Val Pro Tyr Pro Arg Arg Leu Val Val Leu 
785                 790                 795                 800 


Lys Gln Leu Ala His Ser Val Val Leu Ala Trp Glu Pro Pro Pro Glu 
                805                 810                 815     


Gln Val Glu Leu His Gly Phe His Ile Cys Val Asn Gly Glu Leu Arg 
            820                 825                 830         


Gln Ala Leu Gly Pro Gly Ala Pro Pro Lys Ala Val Leu Glu Asn Leu 
        835                 840                 845             


Asp Leu Trp Ala Gly Pro Leu His Ile Ser Val Gln Ala Leu Thr Ser 
    850                 855                 860                 


Arg Gly Ser Ser Asp Pro Leu Arg Cys Cys Leu Ala Val Gly Ala Arg 
865                 870                 875                 880 


Ala Gly Val Val Pro Ser Gln Leu Arg Val His Arg Leu Thr Ala Thr 
                885                 890                 895     


Ser Ala Glu Ile Thr Trp Val Pro Gly Asn Ser Asn Leu Ala His Ala 
            900                 905                 910         


Ile Tyr Leu Asn Gly Glu Glu Cys Pro Pro Ala Ser Pro Ser Thr Tyr 
        915                 920                 925             


Trp Ala Thr Phe Cys His Leu Arg Pro Gly Thr Pro Tyr Gln Ala Gln 
    930                 935                 940                 


Val Glu Ala Gln Leu Pro Pro Gln Gly Pro Trp Glu Pro Gly Trp Glu 
945                 950                 955                 960 


Arg Leu Glu Gln Arg Ala Ala Thr Leu Gln Phe Thr Thr Leu Pro Ala 
                965                 970                 975     


Gly Pro Pro Asp Ala Pro Leu Asp Val Gln Ile Glu Pro Gly Pro Ser 
            980                 985                 990         


Pro Gly Ile Leu Ile Ile Ser Trp  Leu Pro Val Thr Ile  Asp Ala Ala 
        995                 1000                 1005             


Gly Thr  Ser Asn Gly Val Arg  Val Thr Gly Tyr Ala  Ile Tyr Ala 
    1010                 1015                 1020             


Asp Gly  Gln Lys Ile Met Glu  Val Ala Ser Pro Thr  Ala Gly Ser 
    1025                 1030                 1035             


Val Leu  Val Glu Leu Ser Gln  Leu Gln Leu Leu Gln  Val Cys Arg 
    1040                 1045                 1050             


Glu Val  Val Val Arg Thr Met  Ser Pro His Gly Glu  Ser Ala Asp 
    1055                 1060                 1065             


Ser Ile  Pro Ala Pro Ile Thr  Pro Ala Leu Ala Pro  Ala Ser Leu 
    1070                 1075                 1080             


Pro Ala  Arg Val Ser Cys Pro  Ser Pro His Pro Ser  Pro Glu Ala 
    1085                 1090                 1095             


Arg Ala  Pro Leu Ala Ser Ala  Ser Pro Gly Pro Gly  Asp Pro Ser 
    1100                 1105                 1110             


Ser Pro  Leu Gln His Pro Ala  Pro Leu Gly Thr Gln  Glu Pro Pro 
    1115                 1120                 1125             


Gly Ala  Pro Pro Ala Ser Pro  Ser Arg Glu Met Ala  Lys Gly Ser 
    1130                 1135                 1140             


His Glu  Asp Pro Pro Ala Pro  Cys Ser Gln Glu Glu  Ala Gly Ala 
    1145                 1150                 1155             


Ala Val  Leu Gly Thr Ser Glu  Glu Arg Thr Ala Ser  Thr Ser Thr 
    1160                 1165                 1170             


Leu Gly  Glu Lys Asp Pro Gly  Pro Ala Ala Pro Ser  Leu Ala Lys 
    1175                 1180                 1185             


Gln Glu  Ala Glu Trp Thr Ala  Gly Glu Ala Cys Pro  Ala Ser Ser 
    1190                 1195                 1200             


Ser Thr  Gln Gly Ala Arg Ala  Gln Gln Ala Pro Asn  Thr Glu Met 
    1205                 1210                 1215             


Cys Gln  Gly Gly Asp Pro Gly  Ser Gly Leu Arg Pro  Arg Ala Glu 
    1220                 1225                 1230             


Lys Glu  Asp Thr Ala Glu Leu  Gly Val His Leu Val  Asn Ser Leu 
    1235                 1240                 1245             


Val Asp  His Gly Arg Asn Ser  Asp Leu Ser Asp Ile  Gln Glu Glu 
    1250                 1255                 1260             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Leu  Gly Ser Arg 
    1265                 1270                 1275             


Thr Cys  Ser Phe Gln Lys Gln  Val Ala Gly Asn Ser  Ile Arg Glu 
    1280                 1285                 1290             


Asn Gly  Ala Lys Ser Gln Pro  Asp Pro Phe Cys Glu  Thr Asp Ser 
    1295                 1300                 1305             


Asp Glu  Glu Ile Leu Glu Gln  Ile Leu Glu Leu Pro  Leu Gln Gln 
    1310                 1315                 1320             


Phe Cys  Ser Lys Lys Leu Phe  Ser Ile Pro Glu Glu  Glu Glu Glu 
    1325                 1330                 1335             


Glu Glu  Glu Asp Glu Glu Glu  Glu Lys Ser Gly Ala  Gly Cys Ser 
    1340                 1345                 1350             


Ser Arg  Asp Pro Gly Pro Pro  Glu Pro Ala Leu Leu  Gly Leu Gly 
    1355                 1360                 1365             


Cys Asp  Ser Gly Gln Pro Arg  Arg Pro Gly Gln Cys  Pro Leu Ser 
    1370                 1375                 1380             


Pro Glu  Ser Ser Arg Ala Gly  Asp Cys Leu Glu Asp  Met Pro Gly 
    1385                 1390                 1395             


Leu Val  Gly Gly Ser Ser Arg  Arg Arg Gly Gly Gly  Ser Pro Glu 
    1400                 1405                 1410             


Lys Pro  Pro Ser Arg Arg Arg  Pro Pro Asp Pro Arg  Glu His Cys 
    1415                 1420                 1425             


Ser Arg  Leu Leu Ser Asn Asn  Gly Pro Gln Ala Ser  Gly Arg Leu 
    1430                 1435                 1440             


Gly Pro  Thr Arg Glu Arg Gly  Gly Leu Pro Val Ile  Glu Gly Pro 
    1445                 1450                 1455             


Arg Thr  Gly Leu Glu Ala Ser  Gly Arg Gly Arg Leu  Gly Pro Ser 
    1460                 1465                 1470             


Arg Arg  Cys Ser Arg Gly Arg  Ala Leu Glu Pro Gly  Leu Ala Ser 
    1475                 1480                 1485             


Cys Leu  Ser Pro Lys Cys Leu  Glu Ile Ser Ile Glu  Tyr Asp Ser 
    1490                 1495                 1500             


Glu Asp  Glu Gln Glu Ala Gly  Ser Gly Gly Ile Ser  Ile Thr Ser 
    1505                 1510                 1515             


Ser Cys  Tyr Pro Gly Asp Gly  Glu Ala Trp Gly Thr  Ala Thr Val 
    1520                 1525                 1530             


Gly Arg  Pro Arg Gly Pro Pro  Lys Ala Asn Ser Gly  Pro Lys Pro 
    1535                 1540                 1545             


Tyr Pro  Arg Leu Pro Ala Trp  Glu Lys Gly Glu Pro  Glu Arg Arg 
    1550                 1555                 1560             


Gly Arg  Ser Ala Thr Gly Arg  Ala Lys Glu Pro Leu  Ser Arg Ala 
    1565                 1570                 1575             


Thr Glu  Thr Gly Glu Ala Arg  Gly Gln Asp Gly Ser  Gly Arg Arg 
    1580                 1585                 1590             


Gly Pro  Gln Lys Arg Gly Val  Arg Val Leu Arg Pro  Ser Thr Ala 
    1595                 1600                 1605             


Glu Leu  Val Pro Ala Arg Ser  Pro Ser Glu Thr Leu  Ala Tyr Gln 
    1610                 1615                 1620             


His Leu  Pro Val Arg Ile Phe  Val Ala Leu Phe Asp  Tyr Asp Pro 
    1625                 1630                 1635             


Val Ser  Met Ser Pro Asn Pro  Asp Ala Gly Glu Glu  Glu Leu Pro 
    1640                 1645                 1650             


Phe Arg  Glu Gly Gln Ile Leu  Lys Val Phe Gly Asp  Lys Asp Ala 
    1655                 1660                 1665             


Asp Gly  Phe Tyr Gln Gly Glu  Gly Gly Gly Arg Thr  Gly Tyr Ile 
    1670                 1675                 1680             


Pro Cys  Asn Met Val Ala Glu  Val Ala Val Asp Ser  Pro Ala Gly 
    1685                 1690                 1695             


Arg Gln  Gln Leu Leu Gln Arg  Gly Tyr Leu Ser Pro  Asp Ile Leu 
    1700                 1705                 1710             


Leu Glu  Gly Ser Ala His Thr  Thr Gly Pro Pro Pro  Lys Pro Arg 
    1715                 1720                 1725             


Arg Ser  Lys Lys Ala Glu Ser  Glu Gly Pro Ala Gln  Pro Cys Pro 
    1730                 1735                 1740             


Gly Pro  Pro Lys Leu Val Pro  Ser Ala Asp Leu Lys  Ala Pro His 
    1745                 1750                 1755             


Ser Met  Val Ala Ala Phe Asp  Tyr Asn Pro Gln Glu  Ser Ser Pro 
    1760                 1765                 1770             


Asn Met  Asp Val Glu Ala Glu  Leu Pro Phe Arg Ala  Gly Asp Val 
    1775                 1780                 1785             


Ile Thr  Val Phe Gly Gly Met  Asp Asp Asp Gly Phe  Tyr Tyr Gly 
    1790                 1795                 1800             


Glu Leu  Asn Gly Gln Arg Gly  Leu Val Pro Ser Asn  Phe Leu Glu 
    1805                 1810                 1815             


Gly Pro  Gly Pro Glu Ala Gly  Gly Leu Asp Arg Glu  Pro Arg Thr 
    1820                 1825                 1830             


Pro Gln  Ala Glu Ser Gln Arg  Thr Arg Arg Arg Arg  Val Gln Cys 
    1835                 1840                 1845             


<210>  1293
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BZW1__Homo_sapiens__NP_001193996

<400>  1293

Met Asn Asn Gln Lys Gln Gln Lys Pro Thr Leu Ser Gly Gln Arg Phe 
1               5                   10                  15      


Lys Thr Arg Lys Arg Asp Glu Lys Glu Arg Phe Asp Pro Thr Gln Phe 
            20                  25                  30          


Gln Asp Cys Ile Ile Gln Gly Leu Thr Glu Thr Gly Thr Asp Leu Glu 
        35                  40                  45              


Ala Val Ala Lys Phe Leu Asp Ala Ser Gly Ala Lys Leu Asp Tyr Arg 
    50                  55                  60                  


Arg Tyr Ala Glu Thr Leu Phe Asp Ile Leu Val Ala Gly Gly Met Leu 
65                  70                  75                  80  


Ala Pro Gly Gly Thr Leu Ala Asp Asp Met Met Arg Thr Asp Val Cys 
                85                  90                  95      


Val Phe Ala Ala Gln Glu Asp Leu Glu Thr Met Gln Ala Phe Ala Gln 
            100                 105                 110         


Val Phe Asn Lys Leu Ile Arg Arg Tyr Lys Tyr Leu Glu Lys Gly Phe 
        115                 120                 125             


Glu Asp Glu Val Lys Lys Leu Leu Leu Phe Leu Lys Gly Phe Ser Glu 
    130                 135                 140                 


Ser Glu Arg Asn Lys Leu Ala Met Leu Thr Gly Val Leu Leu Ala Asn 
145                 150                 155                 160 


Gly Thr Leu Asn Ala Ser Ile Leu Asn Ser Leu Tyr Asn Glu Asn Leu 
                165                 170                 175     


Val Lys Glu Gly Val Ser Ala Ala Phe Ala Val Lys Leu Phe Lys Ser 
            180                 185                 190         


Trp Ile Asn Glu Lys Asp Ile Asn Ala Val Ala Ala Ser Leu Arg Lys 
        195                 200                 205             


Val Ser Met Asp Asn Arg Leu Met Glu Leu Phe Pro Ala Asn Lys Gln 
    210                 215                 220                 


Ser Val Glu His Phe Thr Lys Tyr Phe Thr Glu Ala Gly Leu Lys Glu 
225                 230                 235                 240 


Leu Ser Glu Tyr Val Arg Asn Gln Gln Thr Ile Gly Ala Arg Lys Glu 
                245                 250                 255     


Leu Gln Lys Glu Leu Gln Glu Gln Met Ser Arg Gly Asp Pro Phe Lys 
            260                 265                 270         


Asp Ile Ile Leu Tyr Val Lys Glu Glu Met Lys Lys Asn Asn Ile Pro 
        275                 280                 285             


Glu Pro Val Val Ile Gly Ile Val Trp Ser Ser Val Met Ser Thr Val 
    290                 295                 300                 


Glu Trp Asn Lys Lys Glu Glu Leu Val Ala Glu Gln Ala Ile Lys His 
305                 310                 315                 320 


Leu Lys Gln Tyr Ser Pro Leu Leu Ala Ala Phe Thr Thr Gln Gly Gln 
                325                 330                 335     


Ser Glu Leu Thr Leu Leu Leu Lys Ile Gln Glu Tyr Cys Tyr Asp Asn 
            340                 345                 350         


Ile His Phe Met Lys Ala Phe Gln Lys Ile Val Val Leu Phe Tyr Lys 
        355                 360                 365             


Ala Glu Val Leu Ser Glu Glu Pro Ile Leu Lys Trp Tyr Lys Asp Ala 
    370                 375                 380                 


His Val Ala Lys Gly Lys Ser Val Phe Leu Glu Gln Met Lys Lys Phe 
385                 390                 395                 400 


Val Glu Trp Leu Lys Asn Ala Glu Glu Glu Ser Glu Ser Glu Ala Glu 
                405                 410                 415     


Glu Gly Asp 
            


<210>  1294
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf107__Homo_sapiens__XP_005269657

<400>  1294

Met Asp Phe Ser Ile Ile Gln Tyr Ser Lys Phe Met Thr Leu Leu Ala 
1               5                   10                  15      


Met Ser Leu Gln Asn Leu Lys Thr Leu His Met Ser Leu Glu Glu Ser 
            20                  25                  30          


Ile Lys Trp Leu Gly Glu Val Met Ala Glu Ile Gly Pro Thr His Ser 
        35                  40                  45              


Gln Lys Ser Glu Asp Trp Asn Ile Phe Asp Val Lys Gln Ala Asn Ala 
    50                  55                  60                  


Ile Ile Asp Tyr Leu Lys Ile Ser Leu Phe Gln His Tyr Lys Leu Tyr 
65                  70                  75                  80  


Glu Phe Met Phe Tyr Ser Ala Arg Glu Glu Ile Val Ile Gly Thr Glu 
                85                  90                  95      


Gln Val Ile Glu Val Val Lys Ser Ala Cys Gly Pro Phe Pro Asn Pro 
            100                 105                 110         


Leu Glu Glu Gly Ile Ser Phe Asp Ile Tyr Ser Thr Phe Ile Glu Pro 
        115                 120                 125             


Pro Thr Ile Leu Asp Thr Glu Met Lys Arg Leu Asp Gln Glu Gln Gly 
    130                 135                 140                 


Pro Glu Glu Ser Gln Pro Glu Thr Asp Thr Ser Asp Met Asp Pro Leu 
145                 150                 155                 160 


Val Gly Phe Thr Ile Glu Asp Val Lys Ser Val Leu Asp Gln Val Thr 
                165                 170                 175     


Asp Asp Ile Leu Ile Gly Ile Gln Thr Glu Ile Asn Glu Lys Leu Gln 
            180                 185                 190         


Ile Gln Glu Glu Ala Phe Asn Ala Arg Ile Glu Lys Leu Lys Lys Ala 
        195                 200                 205             


<210>  1295
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf10__Homo_sapiens__NP_008952

<400>  1295

Met Arg Ser Arg Leu Leu Leu Ser Val Ala His Leu Pro Thr Ile Arg 
1               5                   10                  15      


Glu Thr Thr Glu Glu Met Leu Leu Gly Gly Pro Gly Gln Glu Pro Pro 
            20                  25                  30          


Pro Ser Pro Ser Leu Asp Asp Tyr Val Arg Ser Ile Ser Arg Leu Ala 
        35                  40                  45              


Gln Pro Thr Ser Val Leu Asp Lys Ala Thr Ala Gln Gly Gln Pro Arg 
    50                  55                  60                  


Pro Pro His Arg Pro Ala Gln Ala Cys Arg Lys Gly Arg Pro Ala Val 
65                  70                  75                  80  


Ser Leu Arg Asp Ile Thr Ala Arg Phe Ser Gly Gln Gln Pro Thr Leu 
                85                  90                  95      


Pro Met Ala Asp Thr Val Asp Pro Leu Asp Trp Leu Phe Gly Glu Ser 
            100                 105                 110         


Gln Glu Lys Gln Pro Ser Gln Arg Asp Leu Pro Arg Arg Thr Gly Pro 
        115                 120                 125             


Ser Ala Gly Leu Trp Gly Pro His Arg Gln Met Asp Ser Ser Lys Pro 
    130                 135                 140                 


Met Gly Ala Pro Arg Gly Arg Leu Cys Glu Ala Arg Met Pro Gly His 
145                 150                 155                 160 


Ser Leu Ala Arg Pro Pro Gln Asp Gly Gln Gln Ser Ser Asp Leu Arg 
                165                 170                 175     


Ser Trp Thr Phe Gly Gln Ser Ala Gln Ala Met Ala Ser Arg His Arg 
            180                 185                 190         


Pro Arg Pro Ser Ser Val Leu Arg Thr Leu Tyr Ser His Leu Pro Val 
        195                 200                 205             


Ile His Glu Leu 
    210         


<210>  1296
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf113__Homo_sapiens__NP_001010896

<400>  1296

Met Ala Lys Ser Glu Arg Arg Ile Tyr Ser Met Glu Ser Met Ala Pro 
1               5                   10                  15      


Glu Ile Ser Glu Asp Ile Gly Cys Pro Leu Ala Tyr Met Arg Glu Ser 
            20                  25                  30          


Val Cys Ala Leu Leu Ile Asn Gln Ser Phe Phe Ser Cys Val Ala Glu 
        35                  40                  45              


Met Tyr Ile Pro Asp Met Asn Arg Pro Gly Lys Ala Glu Arg Arg Ala 
    50                  55                  60                  


Glu Lys Gly Leu Arg Pro Pro Arg Lys Leu Val Gly Glu Thr Arg Arg 
65                  70                  75                  80  


Leu Gln Ser Trp Pro Thr Leu Ala Arg Trp Leu Arg Arg Val Ser Phe 
                85                  90                  95      


Ser Leu Tyr Lys Pro Pro Ile Gln Ala Ala Pro Glu Pro Asp Pro Gly 
            100                 105                 110         


Asn Trp Ala Lys Ser Pro Arg Leu Ser Leu Gly Pro Glu Gly Ile Thr 
        115                 120                 125             


Lys Gly Lys His Gly Phe Lys Phe Gln Gly Ile Lys Glu Lys Phe Asn 
    130                 135                 140                 


Val Ser Lys Lys Val Leu Lys Met Thr Phe Leu 
145                 150                 155 


<210>  1297
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf11__Homo_sapiens__NP_114413

<400>  1297

Met Glu Lys Tyr Leu Ser Leu Ser Gly Asn His Ser Ser Asn Lys Arg 
1               5                   10                  15      


Ser Leu Glu Gly Leu Ser Ala Phe Arg Ser Leu Glu Glu Leu Ile Leu 
            20                  25                  30          


Asp Asn Asn Gln Leu Gly Asp Asp Leu Val Leu Pro Gly Leu Pro Arg 
        35                  40                  45              


Leu His Thr Leu Thr Leu Asn Lys Asn Arg Ile Thr Asp Leu Glu Asn 
    50                  55                  60                  


Leu Leu Asp His Leu Ala Glu Val Thr Pro Ala Leu Glu Tyr Leu Ser 
65                  70                  75                  80  


Leu Leu Gly Asn Val Ala Cys Pro Asn Glu Leu Val Ser Leu Glu Lys 
                85                  90                  95      


Asp Glu Glu Asp Tyr Lys Arg Tyr Arg Cys Phe Val Leu Tyr Lys Leu 
            100                 105                 110         


Pro Asn Leu Lys Phe Leu Asp Ala Gln Lys Val Thr Arg Gln Glu Arg 
        115                 120                 125             


Glu Glu Ala Leu Val Arg Gly Val Phe Met Lys Val Val Lys Pro Lys 
    130                 135                 140                 


Ala Ser Ser Glu Asp Val Ala Ser Ser Pro Glu Arg His Tyr Thr Pro 
145                 150                 155                 160 


Leu Pro Ser Ala Ser Arg Glu Leu Thr Ser His Gln Gly Val Leu Gly 
                165                 170                 175     


Lys Cys Arg Tyr Val Tyr Tyr Gly Lys Asn Ser Glu Gly Asn Arg Phe 
            180                 185                 190         


Ile Arg Asp Asp Gln Leu 
        195             


<210>  1298
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf2__Homo_sapiens__NP_001157284

<400>  1298

Met Trp Val Leu Leu Arg Ser Gly Tyr Pro Leu Arg Ile Leu Leu Pro 
1               5                   10                  15      


Leu Arg Gly Glu Trp Met Gly Arg Arg Gly Leu Pro Arg Asn Leu Ala 
            20                  25                  30          


Pro Gly Pro Pro Arg Arg Arg Tyr Arg Lys Glu Thr Leu Gln Ala Leu 
        35                  40                  45              


Asp Met Pro Val Leu Pro Val Thr Ala Thr Glu Ile Arg Gln Tyr Leu 
    50                  55                  60                  


Arg Gly His Gly Ile Pro Phe Gln Asp Gly His Ser Cys Leu Arg Ala 
65                  70                  75                  80  


Leu Ser Pro Phe Ala Glu Ser Ser Gln Leu Lys Gly Gln Thr Gly Val 
                85                  90                  95      


Thr Thr Ser Phe Ser Leu Phe Ile Asp Lys Thr Thr Gly His Phe Leu 
            100                 105                 110         


Cys Met Thr Ser Leu Ala Glu Gly Ser Trp Glu Asp Phe Gln Ala Ser 
        115                 120                 125             


Val Glu Gly Arg Gly Asp Gly Ala Arg Glu Gly Phe Leu Leu Ser Lys 
    130                 135                 140                 


Ala Pro Glu Phe Glu Asp Ser Glu Glu Val Arg Arg Ile Trp Asn Arg 
145                 150                 155                 160 


Ala Ile Pro Leu Trp Glu Leu Pro Asp Gln Glu Glu Val Gln Leu Ala 
                165                 170                 175     


Asp Thr Met Phe Gly Leu Thr Lys Val Thr Asp Asp Thr Leu Lys Arg 
            180                 185                 190         


Phe Ser Val Arg Tyr Leu Arg Pro Ala Arg Ser Leu Val Phe Pro Trp 
        195                 200                 205             


Phe Ser Pro Gly Gly Ser Gly Leu Arg Gly Leu Lys Leu Leu Glu Ala 
    210                 215                 220                 


Lys Cys Gln Gly Asp Gly Val Ser Tyr Glu Glu Thr Thr Ile Pro Arg 
225                 230                 235                 240 


Pro Ser Ala Tyr His Asn Leu Phe Gly Leu Pro Leu Ile Ser Arg Arg 
                245                 250                 255     


Asp Ala Glu Val Val Leu Thr Ser Arg Glu Leu Asp Ser Leu Ala Leu 
            260                 265                 270         


Asn Gln Ser Thr Gly Leu Pro Thr Leu Thr Leu Pro Arg Gly Thr Thr 
        275                 280                 285             


Cys Leu Pro Pro Ala Leu Leu Pro Tyr Leu Glu Gln Phe Arg Arg Ile 
    290                 295                 300                 


Val Phe Trp Leu Gly Asp Asp Leu Arg Ser Trp Glu Ala Ala Lys Leu 
305                 310                 315                 320 


Phe Ala Arg Lys Leu Asn Pro Lys Arg Cys Phe Leu Val Arg Pro Gly 
                325                 330                 335     


Asp Gln Gln Pro Arg Pro Leu Glu Ala Leu Asn Gly Gly Phe Asn Leu 
            340                 345                 350         


Ser Arg Ile Leu Arg Thr Ala Leu Pro Ala Trp His Lys Ser Ile Val 
        355                 360                 365             


Ser Phe Arg Gln Leu Arg Glu Glu Val Leu Gly Glu Leu Ser Asn Val 
    370                 375                 380                 


Glu Gln Ala Ala Gly Leu Arg Trp Ser Arg Phe Pro Asp Leu Asn Arg 
385                 390                 395                 400 


Ile Leu Lys Gly His Arg Lys Gly Glu Leu Thr Val Phe Thr Gly Pro 
                405                 410                 415     


Thr Gly Ser Gly Lys Thr Thr Phe Ile Ser Glu Tyr Ala Leu Asp Leu 
            420                 425                 430         


Cys Ser Gln Gly Val Asn Thr Leu Trp Gly Ser Phe Glu Ile Ser Asn 
        435                 440                 445             


Val Arg Leu Ala Arg Val Met Leu Thr Gln Phe Ala Glu Gly Arg Leu 
    450                 455                 460                 


Glu Asp Gln Leu Asp Lys Tyr Asp His Trp Ala Asp Arg Phe Glu Asp 
465                 470                 475                 480 


Leu Pro Leu Tyr Phe Met Thr Phe His Gly Gln Gln Ser Ile Arg Thr 
                485                 490                 495     


Val Ile Asp Thr Met Gln His Ala Val Tyr Val Tyr Asp Ile Cys His 
            500                 505                 510         


Val Ile Ile Asp Asn Leu Gln Phe Met Met Gly His Glu Gln Leu Ser 
        515                 520                 525             


Thr Asp Arg Ile Ala Ala Gln Asp Tyr Ile Ile Gly Val Phe Arg Lys 
    530                 535                 540                 


Phe Ala Thr Asp Asn Asn Cys His Val Thr Leu Val Ile His Pro Arg 
545                 550                 555                 560 


Lys Glu Asp Asp Asp Lys Glu Leu Gln Thr Ala Ser Ile Phe Gly Ser 
                565                 570                 575     


Ala Lys Val Ser Gly Leu 
            580         


<210>  1299
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf32__Homo_sapiens__NP_001129672

<400>  1299

Met Met Ala Thr Gly Thr Pro Glu Ser Gln Ala Arg Phe Gly Gln Ser 
1               5                   10                  15      


Val Lys Gly Leu Leu Thr Glu Lys Val Thr Thr Cys Gly Thr Asp Val 
            20                  25                  30          


Ile Ala Leu Thr Lys Gln Val Leu Lys Gly Ser Arg Ser Ser Glu Leu 
        35                  40                  45              


Leu Gly Gln Ala Ala Arg Asn Met Val Leu Gln Glu Asp Ala Ile Leu 
    50                  55                  60                  


His Ser Glu Asp Ser Leu Arg Lys Met Ala Ile Ile Thr Thr His Leu 
65                  70                  75                  80  


Gln Tyr Gln Gln Glu Ala Ile Gln Lys Asn Val Glu Gln Ser Ser Asp 
                85                  90                  95      


Leu Gln Asp Gln Leu Asn His Leu Leu Lys 
            100                 105     


<210>  1300
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf35__Homo_sapiens__NP_660349

<400>  1300

Met Val Arg Ile Leu Ala Asn Gly Glu Ile Val Gln Asp Asp Asp Pro 
1               5                   10                  15      


Arg Val Arg Thr Thr Thr Gln Pro Pro Arg Gly Ser Ile Pro Arg Gln 
            20                  25                  30          


Ser Phe Phe Asn Arg Gly His Gly Ala Pro Pro Gly Gly Pro Gly Pro 
        35                  40                  45              


Arg Gln Gln Gln Ala Gly Ala Arg Leu Gly Ala Ala Gln Ser Pro Phe 
    50                  55                  60                  


Asn Asp Leu Asn Arg Gln Leu Val Asn Met Gly Phe Pro Gln Trp His 
65                  70                  75                  80  


Leu Gly Asn His Ala Val Glu Pro Val Thr Ser Ile Leu Leu Leu Phe 
                85                  90                  95      


Leu Leu Met Met Leu Gly Val Arg Gly Leu Leu Leu Val Gly Leu Val 
            100                 105                 110         


Tyr Leu Val Ser His Leu Ser Gln Arg 
        115                 120     


<210>  1301
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf54__Homo_sapiens__NP_071436

<400>  1301

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  1302
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf67__Homo_sapiens__NP_714925

<400>  1302

Met Met Ala Leu Val Arg Asp Arg Arg Ala His Tyr Val Met Ser Ile 
1               5                   10                  15      


Val Ile Arg Trp Val His Cys Phe Ser Ser Ser Leu Arg Gly Thr Phe 
            20                  25                  30          


Gly Thr Arg Trp Glu Ala Met Lys Ala Lys Ala Thr Glu Leu Arg Val 
        35                  40                  45              


Cys Cys Ala Arg Arg Lys Arg Glu Ala Arg Glu Phe Lys Pro Pro Gln 
    50                  55                  60                  


Met Arg Gly Ser Thr Arg Leu Asn Ile Ser Asp Asp Leu Lys Ile Gly 
65                  70                  75                  80  


Phe Phe Ser Thr Asp His Ala Thr Gln Thr Asp Ser Ser Glu Ile Leu 
                85                  90                  95      


Ser Val Lys Glu Leu Ser Ser Ser Thr Gln Lys Leu Ala Gln Met Met 
            100                 105                 110         


Lys Ser Leu Gln Val Asp Phe Gly Phe Leu Lys Gln Leu Leu Gln Leu 
        115                 120                 125             


Lys Phe Glu Asp Arg Leu Lys Glu Glu Ser Leu Ser Leu Phe Thr Ile 
    130                 135                 140                 


Leu His Asp Arg Ile Leu Glu Ile Glu Lys His Tyr Gln Gln Asn Glu 
145                 150                 155                 160 


Asp Lys Met Arg Lys Ser Phe Asn Gln Gln Leu Ala Asp Ala Ile Ala 
                165                 170                 175     


Val Ile Lys Gly Met Tyr Gln Pro Leu 
            180                 185 


<210>  1303
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf82__Homo_sapiens__NP_653262

<400>  1303

Met Glu Pro Ser Lys Thr Phe Met Arg Asn Leu Pro Ile Thr Pro Gly 
1               5                   10                  15      


Tyr Ser Gly Phe Val Pro Phe Leu Ser Cys Gln Gly Met Ser Lys Glu 
            20                  25                  30          


Asp Asp Met Asn His Cys Val Lys Thr Phe Gln Glu Lys Thr Gln Arg 
        35                  40                  45              


Tyr Lys Glu Gln Leu Arg Glu Leu Cys Cys Ala Val Ala Thr Ala Pro 
    50                  55                  60                  


Lys Leu Lys Pro Val Asn Ser Glu Glu Thr Val Leu Gln Ala Leu His 
65                  70                  75                  80  


Gln Tyr Asn Leu Gln Tyr His Pro Leu Ile Leu Glu Cys Lys Tyr Val 
                85                  90                  95      


Lys Lys Pro Leu Gln Glu Pro Pro Ile Pro Gly Trp Ala Gly Tyr Leu 
            100                 105                 110         


Pro Arg Ala Lys Val Thr Glu Phe Gly Cys Gly Thr Arg Tyr Thr Val 
        115                 120                 125             


Met Ala Lys Asn Cys Tyr Lys Asp Phe Leu Glu Ile Thr Glu Arg Ala 
    130                 135                 140                 


Lys Lys Ala His Leu Lys Pro Tyr Glu Glu 
145                 150                 


<210>  1304
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf88__Homo_sapiens__NP_079218

<400>  1304

Met Glu Thr Arg Thr Glu Asp Gly Gly Leu Thr Arg Arg Pro Thr Leu 
1               5                   10                  15      


Ala Ser Ser Trp Asp Val Ala Gly Gly Ala Leu Thr His Ser Leu Leu 
            20                  25                  30          


Leu Thr Arg Ala Gly Leu Gly Pro Gly Asp Phe Asp Trp Glu Glu Leu 
        35                  40                  45              


Leu Ala Pro Pro Ala Pro Gly Gln Asp Leu Val Ile Leu Lys Arg Asn 
    50                  55                  60                  


His Asn Asn Lys Asp Glu Asn Pro Cys Phe Leu Tyr Leu Arg Cys Gly 
65                  70                  75                  80  


Pro Asp Gly Gly Glu Glu Ile Ala Ser Ile Gly Ile Leu Ser Ser Ala 
                85                  90                  95      


Arg Asn Met Glu Val Tyr Leu Gly Glu Glu Tyr Cys Gly Thr Ser Arg 
            100                 105                 110         


Gly Lys Asn Val Cys Thr Val Leu Asp Asp Ser Glu His Glu Lys Ile 
        115                 120                 125             


Ile Leu Tyr Lys Lys Asn Leu Lys Leu Glu Ser Ser Thr His Ala Cys 
    130                 135                 140                 


Lys Ile Lys Leu Leu Ser Phe Gly Glu Arg Gln Cys Val Phe Ile Ser 
145                 150                 155                 160 


Lys Val Val Val His Met Arg Ser Val Phe Ala Asn Ser Ser Thr Ser 
                165                 170                 175     


Ser Pro Ala Leu Gly Ser Arg Ile Asp Leu Asp Lys Val Gln Thr Ile 
            180                 185                 190         


Met Glu Ser Met Gly Ser Lys Leu Ser Pro Gly Ala Gln Gln Leu Met 
        195                 200                 205             


Asp Met Val Arg Cys Gln Gln Arg Asn Cys Ile Pro Ile Gly Glu Gln 
    210                 215                 220                 


Leu Gln Ser Val Leu Gly Asn Ser Gly Tyr Lys His Met Ile Gly Leu 
225                 230                 235                 240 


Gln Ser Ser Ser Thr Leu Gly Thr Leu Asn Lys Ser Ser Ser Thr Pro 
                245                 250                 255     


Phe Pro Phe Arg Thr Gly Leu Thr Ser Gly Asn Val Thr Glu Asn Leu 
            260                 265                 270         


Gln Thr Tyr Ile Asp Lys Ser Thr Gln Leu Pro Gly Gly Glu Asn Ser 
        275                 280                 285             


Thr Lys Leu Asp Glu Cys Lys Val Met Pro Gln Asn His Ser Phe Leu 
    290                 295                 300                 


Glu Asn Asp Leu Lys Asn Ala Met Ala Ser Phe Leu Pro Lys Lys Val 
305                 310                 315                 320 


Ser Asp Asn Ser Asn Ile Pro Asn Ser Glu Leu Leu Pro Phe Leu Gln 
                325                 330                 335     


Asn Leu Cys Ser Gln Val Asn His Leu His Val Gly Asn Lys Thr Glu 
            340                 345                 350         


Cys Gln Glu Asn Ile Thr Lys His Gly Glu Arg Ile Leu Gly Val Gly 
        355                 360                 365             


Met Glu Glu Gln Ser Ile Cys Ser Tyr Leu Glu Lys Ile Leu Ser Lys 
    370                 375                 380                 


Asn Met Glu Leu Met Glu Lys Lys Leu Met Asp Tyr Ile Asp Gln Arg 
385                 390                 395                 400 


Ile His Glu Leu Gln Glu His Ile Asp Asp Lys Ile Ala Leu Leu Leu 
                405                 410                 415     


Asp Leu Leu Gln Asn Pro Asn Ser Pro Pro Thr Gly Ile Pro Leu Arg 
            420                 425                 430         


His Tyr Asp Ser Gly Glu Arg Leu Ser Asn Gly Glu Arg 
        435                 440                 445 


<210>  1305
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10orf90__Homo_sapiens__NP_001004298

<400>  1305

Met Leu Lys Leu Ser Gly Glu Gly Leu Arg Asp Ser Tyr His Ser Arg 
1               5                   10                  15      


Arg Asp Gln Ile Ala Leu Lys Asn Leu Gln Ser Asp Val Thr Glu Ala 
            20                  25                  30          


Lys Ser Asp Phe Thr Lys Glu Thr Leu Ala Ser Gln Asn Thr Lys Met 
        35                  40                  45              


Ile Ser Ser Ile Val Ile Ser Gln Met Ile Asp Glu Asn Lys Ser Arg 
    50                  55                  60                  


Glu Asn Arg Ala Ser Leu Pro Leu Pro Cys Ala Ile Ala Gln Ser Arg 
65                  70                  75                  80  


Ala His His Ala Lys Gln Ser Leu Ala Asn Arg Ser Gly Val Asn Ile 
                85                  90                  95      


His Arg Ala Phe Ala Leu Leu Pro Gly Arg Leu Gly Ile Pro Ala Pro 
            100                 105                 110         


Ser Asp Glu Arg Gly Pro Glu Ala Glu Leu Pro Pro Lys Glu Glu Arg 
        115                 120                 125             


Pro Cys Gly Gly Pro Arg Arg Gly Phe Ala Ser Ile Thr Ile Thr Ala 
    130                 135                 140                 


Arg Arg Val Gly Pro Pro Ala Arg Ala Leu Val Trp Gly Thr Ala Gly 
145                 150                 155                 160 


Asp Ser Leu Cys Pro Lys Cys Arg Ala Glu Asp Thr Leu Phe Gln Ala 
                165                 170                 175     


Pro Pro Ala Leu Ala Asn Gly Ala His Pro Gly Arg His Gln Arg Ser 
            180                 185                 190         


Phe Ala Cys Thr Glu Phe Ser Arg Asn Ser Ser Val Val Arg Leu Lys 
        195                 200                 205             


Val Pro Glu Ala His Thr Gly Leu Cys Glu Arg Arg Lys Tyr Trp Val 
    210                 215                 220                 


Thr His Ala Asp Asp Lys Glu Thr Ser Phe Ser Pro Asp Thr Pro Leu 
225                 230                 235                 240 


Ser Gly Lys Ser Pro Leu Val Phe Ser Ser Cys Val His Leu Arg Val 
                245                 250                 255     


Ser Gln Gln Cys Pro Asp Ser Ile Tyr Tyr Val Asp Lys Ser Leu Ser 
            260                 265                 270         


Val Pro Ile Glu Pro Pro Gln Ile Ala Ser Pro Lys Met His Arg Ser 
        275                 280                 285             


Val Leu Ser Leu Asn Leu Asn Cys Ser Ser His Arg Leu Thr Ala Asp 
    290                 295                 300                 


Gly Val Asp Gly Leu Val Asn Arg Glu Pro Ile Ser Glu Ala Leu Lys 
305                 310                 315                 320 


Gln Glu Leu Leu Glu Gly Asp Gln Asp Leu Val Gly Gln Arg Trp Asn 
                325                 330                 335     


Pro Gly Leu Gln Glu Ser His Leu Lys Glu Thr Pro Ser Leu Arg Arg 
            340                 345                 350         


Val His Leu Gly Thr Gly Ala Cys Pro Trp Ser Gly Ser Phe Pro Leu 
        355                 360                 365             


Glu Asn Thr Glu Leu Ala Asn Val Gly Ala Asn Gln Val Thr Val Arg 
    370                 375                 380                 


Lys Gly Glu Lys Asp His Thr Thr His Cys His Ala Ser Asp His Ala 
385                 390                 395                 400 


Asn Gln Leu Ser Ile His Ile Pro Gly Trp Ser Tyr Arg Ala Val His 
                405                 410                 415     


Thr Lys Val Phe Ser Gly Ser Ser Lys Arg Gln Gln Gly Glu Val Cys 
            420                 425                 430         


Met Thr Val Ser Ala Pro Pro Val Glu Gln Lys Pro Thr Arg His Phe 
        435                 440                 445             


Leu Pro Ile Gly Asp Ser Ser Pro Ser Asp Asp Cys Leu Ser Arg Asp 
    450                 455                 460                 


Leu Ser Glu Pro Thr Glu Arg Arg His Gln Ser Phe Leu Lys Pro Arg 
465                 470                 475                 480 


Ile Leu Phe Pro Gly Phe Leu Cys Pro Leu Gln Asp Val Cys Ala Ser 
                485                 490                 495     


Leu Gln Glu Asp Asn Gly Val Gln Ile Glu Ser Lys Phe Pro Lys Gly 
            500                 505                 510         


Asp Tyr Thr Cys Cys Asp Leu Val Val Lys Ile Lys Glu Cys Lys Lys 
        515                 520                 525             


Ser Glu Asp Pro Thr Thr Pro Glu Pro Ser Pro Ala Ala Pro Ser Pro 
    530                 535                 540                 


Ala Pro Arg Asp Gly Ala Gly Ser Pro Gly Leu Ser Glu Asp Cys Ser 
545                 550                 555                 560 


Glu Ser Gln Gln Thr Pro Ala Arg Ser Leu Thr Leu Gln Glu Ala Leu 
                565                 570                 575     


Glu Val Arg Lys Pro Gln Phe Ile Ser Arg Ser Gln Glu Arg Leu Lys 
            580                 585                 590         


Lys Leu Glu His Met Val Gln Gln Arg Lys Ala Gln Arg Lys Glu Asp 
        595                 600                 605             


Leu Arg Gln Lys Gln Ser Leu Leu Pro Ile Arg Thr Ser Lys Lys Gln 
    610                 615                 620                 


Phe Thr Ile Pro His Pro Leu Ser Asp Asn Leu Phe Lys Pro Lys Glu 
625                 630                 635                 640 


Arg Cys Ile Ser Glu Lys Glu Met His Met Arg Ser Lys Arg Ile Tyr 
                645                 650                 655     


Asp Asn Leu Pro Glu Val Lys Lys Lys Lys Glu Glu Gln Arg Lys Arg 
            660                 665                 670         


Val Ile Leu Gln Ser Asn Arg Leu Arg Ala Glu Val Phe Lys Lys Gln 
        675                 680                 685             


Leu Leu Asp Gln Leu Leu Gln Arg Asn Ala Val 
    690                 695                 


<210>  1306
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf21__Homo_sapiens__NP_001136418

<400>  1306

Met Ala Ser Phe Leu Val Trp Pro Leu Arg Thr Ala Leu Arg Gly Gly 
1               5                   10                  15      


Lys Ser Trp Ala Gly Pro Gly Val Gly Cys Gly Gly Asp Gly Ala Arg 
            20                  25                  30          


Gly Gly Gly Glu Leu Ser Leu Ser Asn Leu Asp Leu Pro Gly Ala Gly 
        35                  40                  45              


Glu Ala Gly Leu Glu His His Pro Leu Leu Gly His Leu Phe Ile Ser 
    50                  55                  60                  


Ala Val Pro Arg Trp Pro His Leu Ser Ser Gln Ser Gly Val Glu Pro 
65                  70                  75                  80  


Pro Asp Arg Trp Thr Gly Thr Pro Gly Trp Pro Ser Arg Asp Gln Glu 
                85                  90                  95      


Ala Pro Gly Ser Met Met Pro Pro Ala Ala Ala Gln Pro Ser Ala His 
            100                 105                 110         


Gly Ala Leu Val Pro Pro Ala Thr Ala His Glu Pro Val Asp His Pro 
        115                 120                 125             


Ala Leu His Trp Leu Ala Cys Cys Cys Cys Leu Ser Leu Pro Gly Gln 
    130                 135                 140                 


Leu Pro Leu Ala Ile Arg Leu Gly Trp Asp Leu Asp Leu Glu Ala Gly 
145                 150                 155                 160 


Pro Ser Ser Gly Lys Leu Cys Pro Arg Ala Arg Arg Trp Gln Pro Leu 
                165                 170                 175     


Pro Ser 
        


<210>  1307
<211>  1322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf30__Homo_sapiens__NP_064578

<400>  1307

Met Pro Val Val Trp Pro Thr Leu Leu Asp Leu Ser Arg Asp Glu Cys 
1               5                   10                  15      


Lys Arg Ile Leu Arg Lys Leu Glu Leu Glu Ala Tyr Ala Gly Val Ile 
            20                  25                  30          


Ser Ala Leu Arg Ala Gln Gly Asp Leu Thr Lys Glu Lys Lys Asp Leu 
        35                  40                  45              


Leu Gly Glu Leu Ser Lys Val Leu Ser Ile Ser Thr Glu Arg His Arg 
    50                  55                  60                  


Ala Glu Val Arg Arg Ala Val Asn Asp Glu Arg Leu Thr Thr Ile Ala 
65                  70                  75                  80  


His Asn Met Ser Gly Pro Asn Ser Ser Ser Glu Trp Ser Ile Glu Gly 
                85                  90                  95      


Arg Arg Leu Val Pro Leu Met Pro Arg Leu Val Pro Gln Thr Ala Phe 
            100                 105                 110         


Thr Val Thr Ala Asn Ala Val Ala Asn Ala Ala Ile Gln His Asn Ala 
        115                 120                 125             


Ser Leu Pro Val Pro Ala Glu Thr Gly Ser Lys Glu Val Val Cys Tyr 
    130                 135                 140                 


Ser Tyr Thr Ser Thr Thr Ser Thr Pro Thr Ser Thr Pro Val Pro Ser 
145                 150                 155                 160 


Gly Ser Ile Ala Thr Val Lys Ser Pro Arg Pro Ala Ser Pro Ala Ser 
                165                 170                 175     


Asn Val Val Val Leu Pro Ser Gly Ser Thr Val Tyr Val Lys Ser Val 
            180                 185                 190         


Ser Cys Ser Asp Glu Asp Glu Lys Pro Arg Lys Arg Arg Arg Thr Asn 
        195                 200                 205             


Ser Ser Ser Ser Ser Pro Val Val Leu Lys Glu Val Pro Lys Ala Val 
    210                 215                 220                 


Val Pro Val Ser Lys Thr Ile Thr Val Pro Val Ser Gly Ser Pro Lys 
225                 230                 235                 240 


Met Ser Asn Ile Met Gln Ser Ile Ala Asn Ser Leu Pro Pro His Met 
                245                 250                 255     


Ser Pro Val Lys Ile Thr Phe Thr Lys Pro Ser Thr Gln Thr Thr Asn 
            260                 265                 270         


Thr Thr Thr Gln Lys Val Ile Ile Val Thr Thr Ser Pro Ser Ser Thr 
        275                 280                 285             


Phe Val Pro Asn Ile Leu Ser Lys Ser His Asn Tyr Ala Ala Val Thr 
    290                 295                 300                 


Lys Leu Val Pro Thr Ser Val Ile Ala Ser Thr Thr Gln Lys Pro Pro 
305                 310                 315                 320 


Val Val Ile Thr Ala Ser Gln Ser Ser Leu Val Ser Asn Ser Ser Ser 
                325                 330                 335     


Gly Ser Ser Ser Ser Thr Pro Ser Pro Ile Pro Asn Thr Val Ala Val 
            340                 345                 350         


Thr Ala Val Val Ser Ser Thr Pro Ser Val Val Met Ser Thr Val Ala 
        355                 360                 365             


Gln Gly Val Ser Thr Ser Ala Ile Lys Met Ala Ser Thr Arg Leu Pro 
    370                 375                 380                 


Ser Pro Lys Ser Leu Val Ser Ala Pro Thr Gln Ile Leu Ala Gln Phe 
385                 390                 395                 400 


Pro Lys Gln His Gln Gln Ser Pro Lys Gln Gln Leu Tyr Gln Val Gln 
                405                 410                 415     


Gln Gln Thr Gln Gln Gln Val Ala Gln Pro Ser Pro Val Ser His Gln 
            420                 425                 430         


Gln Gln Pro Gln Gln Ser Pro Leu Pro Pro Gly Ile Lys Pro Thr Ile 
        435                 440                 445             


Gln Ile Lys Gln Glu Ser Gly Val Lys Ile Ile Thr Gln Gln Val Gln 
    450                 455                 460                 


Pro Ser Lys Ile Leu Pro Lys Pro Val Thr Ala Thr Leu Pro Thr Ser 
465                 470                 475                 480 


Ser Asn Ser Pro Ile Met Val Val Ser Ser Asn Gly Ala Ile Met Thr 
                485                 490                 495     


Thr Lys Leu Val Thr Thr Pro Thr Gly Thr Gln Ala Thr Tyr Thr Arg 
            500                 505                 510         


Pro Thr Val Ser Pro Ser Ile Gly Arg Met Ala Ala Thr Pro Gly Ala 
        515                 520                 525             


Ala Thr Tyr Val Lys Thr Thr Ser Gly Ser Ile Ile Thr Val Val Pro 
    530                 535                 540                 


Lys Ser Leu Ala Thr Leu Gly Gly Lys Ile Ile Ser Ser Asn Ile Val 
545                 550                 555                 560 


Ser Gly Thr Thr Thr Lys Ile Thr Thr Ile Pro Met Thr Ser Lys Pro 
                565                 570                 575     


Asn Val Ile Val Val Gln Lys Thr Thr Gly Lys Gly Thr Thr Ile Gln 
            580                 585                 590         


Gly Leu Pro Gly Lys Asn Val Val Thr Thr Leu Leu Asn Ala Gly Gly 
        595                 600                 605             


Glu Lys Thr Ile Gln Thr Val Pro Thr Gly Ala Lys Pro Ala Ile Leu 
    610                 615                 620                 


Thr Ala Thr Arg Pro Ile Thr Lys Met Ile Val Thr Gln Pro Lys Gly 
625                 630                 635                 640 


Ile Gly Ser Thr Val Gln Pro Ala Ala Lys Ile Ile Pro Thr Lys Ile 
                645                 650                 655     


Val Tyr Gly Gln Gln Gly Lys Thr Gln Val Leu Ile Lys Pro Lys Pro 
            660                 665                 670         


Val Thr Phe Gln Ala Thr Val Val Ser Glu Gln Thr Arg Gln Leu Val 
        675                 680                 685             


Thr Glu Thr Leu Gln Gln Ala Ser Arg Val Ala Glu Ala Gly Asn Ser 
    690                 695                 700                 


Ser Ile Gln Glu Gly Lys Glu Glu Pro Gln Asn Tyr Thr Asp Ser Ser 
705                 710                 715                 720 


Ser Ser Ser Thr Glu Ser Ser Gln Ser Ser Gln Asp Ser Gln Pro Val 
                725                 730                 735     


Val His Val Ile Ala Ser Arg Arg Gln Asp Trp Ser Glu His Glu Ile 
            740                 745                 750         


Ala Met Glu Thr Ser Pro Thr Ile Ile Tyr Gln Asp Val Ser Ser Glu 
        755                 760                 765             


Ser Gln Ser Ala Thr Ser Thr Ile Lys Ala Leu Leu Glu Leu Gln Gln 
    770                 775                 780                 


Thr Thr Val Lys Glu Lys Leu Glu Ser Lys Pro Arg Gln Pro Thr Ile 
785                 790                 795                 800 


Asp Leu Ser Gln Met Ala Val Pro Ile Gln Met Thr Gln Glu Lys Arg 
                805                 810                 815     


His Ser Pro Glu Ser Pro Ser Ile Ala Val Val Glu Ser Glu Leu Val 
            820                 825                 830         


Ala Glu Tyr Ile Thr Thr Glu Arg Thr Asp Glu Gly Thr Glu Val Ala 
        835                 840                 845             


Phe Pro Leu Leu Val Ser His Arg Ser Gln Pro Gln Gln Pro Ser Gln 
    850                 855                 860                 


Pro Gln Arg Thr Leu Leu Gln His Val Ala Gln Ser Gln Thr Ala Thr 
865                 870                 875                 880 


Gln Thr Ser Val Val Val Lys Ser Ile Pro Ala Ser Ser Pro Gly Ala 
                885                 890                 895     


Ile Thr His Ile Met Gln Gln Ala Leu Ser Ser His Thr Ala Phe Thr 
            900                 905                 910         


Lys His Ser Glu Glu Leu Gly Thr Glu Glu Gly Glu Val Glu Glu Met 
        915                 920                 925             


Asp Thr Leu Asp Pro Gln Thr Gly Leu Phe Tyr Arg Ser Ala Leu Thr 
    930                 935                 940                 


Gln Ser Gln Ser Ala Lys Gln Gln Lys Leu Ser Gln Pro Pro Leu Glu 
945                 950                 955                 960 


Gln Thr Gln Leu Gln Val Lys Thr Leu Gln Cys Phe Gln Thr Lys Gln 
                965                 970                 975     


Lys Gln Thr Ile His Leu Gln Ala Asp Gln Leu Gln His Lys Leu Pro 
            980                 985                 990         


Gln Met Pro Gln Leu Ser Ile Arg  His Gln Lys Leu Thr  Pro Leu Gln 
        995                 1000                 1005             


Gln Glu  Gln Ala Gln Pro Lys  Pro Asp Val Gln His  Thr Gln His 
    1010                 1015                 1020             


Pro Met  Val Ala Lys Asp Arg  Gln Leu Pro Thr Leu  Met Ala Gln 
    1025                 1030                 1035             


Pro Pro  Gln Thr Val Val Gln  Val Leu Ala Val Lys  Thr Thr Gln 
    1040                 1045                 1050             


Gln Leu  Pro Lys Leu Gln Gln  Ala Pro Asn Gln Pro  Lys Ile Tyr 
    1055                 1060                 1065             


Val Gln  Pro Gln Thr Pro Gln  Ser Gln Met Ser Leu  Pro Ala Ser 
    1070                 1075                 1080             


Ser Glu  Lys Gln Thr Ala Ser  Gln Val Glu Gln Pro  Ile Ile Thr 
    1085                 1090                 1095             


Gln Gly  Ser Ser Val Thr Lys  Ile Thr Phe Glu Gly  Arg Gln Pro 
    1100                 1105                 1110             


Pro Thr  Val Thr Lys Ile Thr  Gly Gly Ser Ser Val  Pro Lys Leu 
    1115                 1120                 1125             


Thr Ser  Pro Val Thr Ser Ile  Ser Pro Ile Gln Ala  Ser Glu Lys 
    1130                 1135                 1140             


Thr Ala  Val Ser Asp Ile Leu  Lys Met Ser Leu Met  Glu Ala Gln 
    1145                 1150                 1155             


Ile Asp  Thr Asn Val Glu His  Met Ile Val Asp Pro  Pro Lys Lys 
    1160                 1165                 1170             


Ala Leu  Ala Thr Ser Met Leu  Thr Gly Glu Ala Gly  Ser Leu Pro 
    1175                 1180                 1185             


Ser Thr  His Met Val Val Ala  Gly Met Ala Asn Ser  Thr Pro Gln 
    1190                 1195                 1200             


Gln Gln  Lys Cys Arg Glu Ser  Cys Ser Ser Pro Ser  Thr Val Gly 
    1205                 1210                 1215             


Ser Ser  Leu Thr Thr Arg Lys  Ile Asp Pro Pro Ala  Val Pro Ala 
    1220                 1225                 1230             


Thr Gly  Gln Phe Met Arg Ile  Gln Asn Val Gly Gln  Lys Lys Ala 
    1235                 1240                 1245             


Glu Glu  Ser Pro Ala Glu Ile  Ile Ile Gln Ala Ile  Pro Gln Tyr 
    1250                 1255                 1260             


Ala Ile  Pro Cys His Ser Ser  Ser Asn Val Val Val  Glu Pro Ser 
    1265                 1270                 1275             


Gly Leu  Leu Glu Leu Asn Asn  Phe Thr Ser Gln Gln  Leu Asp Asp 
    1280                 1285                 1290             


Glu Glu  Thr Ala Met Glu Gln  Asp Ile Asp Ser Ser  Thr Glu Asp 
    1295                 1300                 1305             


Gly Thr  Glu Pro Ser Pro Ser  Gln Ser Ser Ala Glu  Arg Ser 
    1310                 1315                 1320         


<210>  1308
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf53__Homo_sapiens__NP_940900

<400>  1308

Met Pro Gly Ser Pro Val Thr Ser Gly Tyr Tyr Gly Val Arg Arg Ser 
1               5                   10                  15      


Phe Leu Ser Asp Ser Asp Phe His Asn Ser Lys Gln Phe Ser Asn Asp 
            20                  25                  30          


Val Tyr Thr Ser Ser Val Gly Lys Pro Phe Pro Cys Glu Ser Ser Ala 
        35                  40                  45              


Gly Gln Ser His Ala Ala Leu Leu Glu Pro Tyr Phe Pro Gln Glu Pro 
    50                  55                  60                  


Tyr Gly Asp Tyr Arg Pro Pro Ala Leu Thr Pro Asn Ala Gly Ser Leu 
65                  70                  75                  80  


Phe Ser Ala Ser Pro Leu Pro Pro Leu Leu Pro Pro Pro Phe Pro Gly 
                85                  90                  95      


Asp Pro Ala His Phe Leu Phe Arg Asp Ser Trp Glu Gln Thr Leu Pro 
            100                 105                 110         


Asp Gly Leu Ser Gln Pro Asp Pro Val Ser Ala Asp Ala Leu Leu Thr 
        115                 120                 125             


Leu Pro Pro Ser Thr Ser Cys Leu Ser Gln Leu Glu Ser Gly Ser Ile 
    130                 135                 140                 


Ala Gln His Arg Gly Ser Ser Trp Gly Ser Ser Leu Ala Gly Ala Gln 
145                 150                 155                 160 


Ser Tyr Ser Leu His Ala Leu Glu Asp Leu His His Thr Pro Gly Tyr 
                165                 170                 175     


Pro Thr Pro Pro Pro Tyr Pro Phe Thr Pro Phe Met Thr Val Ser Asn 
            180                 185                 190         


Asp Leu Pro Pro Lys Val Gly Pro Leu Ser Pro Asp Glu Glu Ala Asp 
        195                 200                 205             


Thr Gly Ser Leu His Asp Pro Ser Pro Trp Val Lys Glu Asp Gly Ser 
    210                 215                 220                 


Ile Ala Trp Gly Ser Tyr Glu Cys Arg Arg Ala Tyr 
225                 230                 235     


<210>  1309
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf65__Homo_sapiens__NP_689800

<400>  1309

Met Pro Trp Lys Glu Glu Ser Glu Phe Thr Lys Gln Asp Lys Ala Ala 
1               5                   10                  15      


Arg Val Ile Gln Gln Ala Trp Lys Ser Phe Leu Asn Val Ala Ile Phe 
            20                  25                  30          


Gln His Phe Lys Ser Leu Ile Asp Leu Arg Arg Gln Gly Glu Pro Arg 
        35                  40                  45              


Gln Ile Val Lys Tyr Ile Asn Pro Lys Glu Ala Glu Leu Leu Asp Ala 
    50                  55                  60                  


Ala Ala Gly Ile His Val Arg Phe Arg Leu Gly Gly Val Lys Phe Pro 
65                  70                  75                  80  


Pro Asp Ile Tyr Tyr Lys Ile Phe Thr His Arg Pro Ile Glu Asp Leu 
                85                  90                  95      


Cys Ala Asn Ser Pro Arg Asn Tyr Ala Lys Leu Pro Ala Lys His Thr 
            100                 105                 110         


Ser His Asn Lys Asn Asp His Leu Gln Glu Glu Asp His Ser Gly Trp 
        115                 120                 125             


Tyr His Arg Ile Glu Asn Asn Gly Trp Arg Pro Val Ser Asp Thr Phe 
    130                 135                 140                 


Trp Leu Ser Thr Asp Gly Met Val Val Glu Asp Lys Lys Glu Ser Glu 
145                 150                 155                 160 


Phe His Phe Ser Lys Leu Lys Arg Arg Gln Asp Leu Glu Lys Lys Arg 
                165                 170                 175     


Lys Leu Arg Lys Ile Glu Trp Met Arg Gln Met Tyr Tyr Ser Gly Ser 
            180                 185                 190         


Leu Glu Ala Lys Ser Thr His His Glu Thr Leu Gly Leu Ile His Thr 
        195                 200                 205             


Ala Thr Lys Gly Leu Ile Arg Ala Phe Glu Asp Gly Gly Ile Asp Ser 
    210                 215                 220                 


Val Met Glu Trp Glu Val Asp Glu Val Leu Asn Trp Thr Asn Thr Leu 
225                 230                 235                 240 


Asn Phe Asp Glu Tyr Ile Ala Ser Trp Lys Glu Ile Ala Thr Ser Asn 
                245                 250                 255     


Ser Ser Ala Asn Phe Lys Gly Phe Arg Phe Asn Gln Ala Gln Lys Asn 
            260                 265                 270         


Ile Tyr Asn Tyr Gly Gly Asp Ile Ser Lys Met Gln Met Gly Ile Pro 
        275                 280                 285             


Asp Asp Thr Tyr Tyr Glu Asn Val Tyr Gln Glu Pro Asn Val Thr Arg 
    290                 295                 300                 


Leu Thr Pro Asp Ser Thr Tyr Gly Leu 
305                 310             


<210>  1310
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf68__Homo_sapiens__NP_001129107

<400>  1310

Met Ala Ala Ala Ala Ala Ala Ala Val Ala Gly Val Gly Arg Gly Gly 
1               5                   10                  15      


Gly Gly Ala Glu Pro Arg Gln Glu Arg Ser Arg Ala Arg Gly Trp Ala 
            20                  25                  30          


Gly Val Glu Arg Ser Glu Gly Arg Ser Arg Met Glu Pro Gly Glu Glu 
        35                  40                  45              


Leu Glu Glu Glu Gly Ser Pro Gly Gly Arg Glu Asp Gly Phe Thr Ala 
    50                  55                  60                  


Glu His Leu Ala Ala Glu Ala Met Ala Ala Asp Met Asp Pro Trp Leu 
65                  70                  75                  80  


Val Phe Asp Ala Arg Thr Thr Pro Ala Thr Glu Leu Asp Ala Trp Leu 
                85                  90                  95      


Ala Lys Tyr Pro Pro Ser Gln Val Thr Arg Tyr Gly Asp Pro Gly Ser 
            100                 105                 110         


Pro Asn Ser Glu Pro Val Gly Trp Ile Ala Val Tyr Gly Gln Gly Tyr 
        115                 120                 125             


Ser Pro Asn Ser Gly Asp Val Gln Gly Leu Gln Ala Ala Trp Glu Ala 
    130                 135                 140                 


Leu Gln Thr Ser Gly Arg Pro Ile Thr Pro Gly Thr Leu Arg Gln Leu 
145                 150                 155                 160 


Ala Ile Thr His His Val Leu Ser Gly Lys Trp Leu Met His Leu Ala 
                165                 170                 175     


Pro Gly Phe Lys Leu Asp His Ala Trp Ala Gly Ile Ala Arg Ala Val 
            180                 185                 190         


Val Glu Gly Gln Leu Gln Val Ala Lys Val Ser Pro Arg Ala Lys Glu 
        195                 200                 205             


Gly Gly Arg Gln Val Ile Cys Val Tyr Thr Asp Asp Phe Thr Asp Arg 
    210                 215                 220                 


Leu Gly Val Leu Glu Ala Asp Ser Ala Ile Arg Ala Ala Gly Ile Lys 
225                 230                 235                 240 


Cys Leu Leu Thr Tyr Lys Pro Asp Val Tyr Thr Tyr Leu Gly Ile Tyr 
                245                 250                 255     


Arg Ala Asn Arg Trp His Leu Cys Pro Thr Leu Tyr Glu Ser Arg Phe 
            260                 265                 270         


Gln Leu Gly Gly Ser Ala Arg Gly Ser Arg Val Leu Asp Arg Ala Asn 
        275                 280                 285             


Asn Val Glu Leu Thr 
    290             


<210>  1311
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf73__Homo_sapiens__NP_057485

<400>  1311

Met Phe Gly Cys Leu Val Ala Gly Arg Leu Val Gln Thr Ala Ala Gln 
1               5                   10                  15      


Gln Val Ala Glu Asp Lys Phe Val Phe Asp Leu Pro Asp Tyr Glu Ser 
            20                  25                  30          


Ile Asn His Val Val Val Phe Met Leu Gly Thr Ile Pro Phe Pro Glu 
        35                  40                  45              


Gly Met Gly Gly Ser Val Tyr Phe Ser Tyr Pro Asp Ser Asn Gly Met 
    50                  55                  60                  


Pro Val Trp Gln Leu Leu Gly Phe Val Thr Asn Gly Lys Pro Ser Ala 
65                  70                  75                  80  


Ile Phe Lys Ile Ser Gly Leu Lys Ser Gly Glu Gly Ser Gln His Pro 
                85                  90                  95      


Phe Gly Ala Met Asn Ile Val Arg Thr Pro Ser Val Ala Gln Ile Gly 
            100                 105                 110         


Ile Ser Val Glu Leu Leu Asp Ser Met Ala Gln Gln Thr Pro Val Gly 
        115                 120                 125             


Asn Ala Ala Val Ser Ser Val Asp Ser Phe Thr Gln Phe Thr Gln Lys 
    130                 135                 140                 


Met Leu Asp Asn Phe Tyr Asn Phe Ala Ser Ser Phe Ala Val Ser Gln 
145                 150                 155                 160 


Ala Gln Met Thr Pro Ser Pro Ser Glu Met Phe Ile Pro Ala Asn Val 
                165                 170                 175     


Val Leu Lys Trp Tyr Glu Asn Phe Gln Arg Arg Leu Ala Gln Asn Pro 
            180                 185                 190         


Leu Phe Trp Lys Thr 
        195         


<210>  1312
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf74__Homo_sapiens__NP_001263656

<400>  1312

Met Ser Ala His Met Ser Gly Leu Glu Ile Met Asp Glu Asp Gln Leu 
1               5                   10                  15      


Ile Lys Asp Val Leu Asp Lys Phe Leu Asn Cys His Glu Gln Thr Tyr 
            20                  25                  30          


Asp Glu Glu Phe Leu Asn Thr Phe Thr His Leu Ser Gln Asp Leu Leu 
        35                  40                  45              


Leu Leu Pro Gly Glu Val Glu Gln Asp Val Ser Thr Ser Ile Pro Ser 
    50                  55                  60                  


Cys Ile Pro Phe Val Ala Gln Pro Pro Thr Cys Glu Val Lys Pro Lys 
65                  70                  75                  80  


Pro Ser Val Lys Arg Met Asp Lys Gln Thr Glu Glu Ile Leu Gly Asp 
                85                  90                  95      


Glu Val Gln Leu Phe Ser Leu Asp Glu Glu Phe Asp Tyr Asp Asn Val 
            100                 105                 110         


Met Leu Thr Ser Lys Phe Ser Pro Ala Glu Ile Glu Asn Ile Lys Glu 
        115                 120                 125             


Leu Cys Lys Gln Gln Lys Arg Lys Asp Thr Ser Pro Asp Leu Glu Lys 
    130                 135                 140                 


Ser Cys Asp 
145         


<210>  1313
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf80__Homo_sapiens__NP_001289013

<400>  1313

Met Val Leu Lys Lys Phe Leu Lys Glu Ile Gln Ser Ile Leu Pro Gly 
1               5                   10                  15      


Ile Ser Ala Lys Leu Thr Trp Thr Ser Glu Glu Gly Ser Tyr Ser Gln 
            20                  25                  30          


Asp Met Thr Gly Val Thr Pro Phe Gln Met Ile Phe Glu Val Asp Glu 
        35                  40                  45              


Lys Pro Arg Thr Leu Met Thr Asp Cys Leu Val Ile Lys His Phe Leu 
    50                  55                  60                  


Arg Lys Ile Ile Met Val His Pro Lys Val Arg Phe His Phe Ser Val 
65                  70                  75                  80  


Lys Val Asn Gly Ile Leu Ser Thr Glu Ile Phe Gly Val Glu Asn Glu 
                85                  90                  95      


Pro Thr Leu Asn Leu Gly Asn Gly Ile Ala Leu Leu Val Asp Ser Gln 
            100                 105                 110         


His Tyr Val Ser Arg Pro Asn Phe Gly Thr Ile Glu Ser His Cys Ser 
        115                 120                 125             


Arg Ile His Pro Val Leu Gly His Pro Val Met Leu Phe Ile Pro Glu 
    130                 135                 140                 


Asp Val Ala Gly Met Asp Leu Leu Gly Glu Leu Ile Leu Thr Pro Ala 
145                 150                 155                 160 


Ala Ala Leu Cys Pro Ser Pro Lys Val Ser Ser Asn Gln Leu Asn Arg 
                165                 170                 175     


Ile Ser Ser Val Ser Ile Phe Leu Tyr Gly Pro Leu Gly Leu Pro Leu 
            180                 185                 190         


Ile Leu Ser Thr Trp Glu Gln Pro Met Thr Thr Phe Phe Lys Asp Thr 
        195                 200                 205             


Ser Ser Leu Val Asp Trp Lys Lys Tyr His Leu Cys Met Ile Pro Asn 
    210                 215                 220                 


Leu Asp Leu Asn Leu Asp Arg Asp Leu Val Leu Pro Asp Val Ser Tyr 
225                 230                 235                 240 


Gln Val Glu Ser Ser Glu Glu Asp Gln Ser Gln Thr Met Asp Pro Gln 
                245                 250                 255     


Gly Gln Thr Leu Leu Leu Phe Leu Phe Val Asp Phe His Ser Ala Phe 
            260                 265                 270         


Pro Val Gln Gln Met Glu Ile Trp Gly Val Tyr Thr Leu Leu Thr Thr 
        275                 280                 285             


His Leu Asn Ala Ile Leu Val Glu Ser His Ser Val Val Gln Gly Ser 
    290                 295                 300                 


Ile Gln Phe Thr Val Asp Lys Val Leu Glu Gln His His Gln Ala Ala 
305                 310                 315                 320 


Lys Ala Gln Gln Lys Leu Gln Ala Ser Leu Ser Val Ala Val Asn Ser 
                325                 330                 335     


Ile Met Ser Ile Leu Thr Gly Ser Thr Arg Ser Ser Phe Arg Lys Met 
            340                 345                 350         


Cys Leu Gln Thr Leu Gln Ala Ala Asp Thr Gln Glu Phe Arg Thr Lys 
        355                 360                 365             


Leu His Lys Val Phe Arg Glu Ile Thr Gln His Gln Phe Leu His His 
    370                 375                 380                 


Cys Ser Cys Glu Val Lys Gln Leu Thr Leu Glu Lys Lys Asp Ser Ala 
385                 390                 395                 400 


Gln Gly Thr Glu Asp Ala Pro Asp Asn Ser Ser Leu Glu Leu Leu Ala 
                405                 410                 415     


Asp Thr Ser Gly Gln Ala Glu Asn Lys Arg Leu Lys Arg Gly Ser Pro 
            420                 425                 430         


Arg Ile Glu Glu Met Arg Ala Leu Arg Ser Ala Arg Ala Pro Ser Pro 
        435                 440                 445             


Ser Glu Ala Ala Pro Arg Arg Pro Glu Ala Thr Ala Ala Pro Leu Thr 
    450                 455                 460                 


Pro Arg Gly Arg Glu His Arg Glu Ala His Gly Arg Ala Leu Ala Pro 
465                 470                 475                 480 


Gly Arg Ala Ser Leu Gly Ser Arg Leu Glu Asp Val Leu Trp Leu Gln 
                485                 490                 495     


Glu Val Ser Asn Leu Ser Glu Trp Leu Ser Pro Ser Pro Gly Pro 
            500                 505                 510     


<210>  1314
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf87__Homo_sapiens__XP_011541119

<400>  1314

Met Gly Pro Lys Gly Ser Asp Ala Val Gln Gly Gly Arg Val Trp Thr 
1               5                   10                  15      


Gly Arg Glu Arg Lys Gly Gly Leu Arg Thr Arg Ser Pro Arg Gly Gly 
            20                  25                  30          


Pro Glu Trp Val Leu Gly Arg Val Gly Ser Arg Arg Arg His Gln Pro 
        35                  40                  45              


Arg Gly Arg Arg Lys Glu Glu Ser Arg Arg Ser Gly Asn Leu Val Pro 
    50                  55                  60                  


Leu Gln Arg Lys Gly Glu Arg Gly Asp Val Phe Glu Val Val Ser Ala 
65                  70                  75                  80  


Arg Ile Ser Arg Ala Pro Leu Thr Pro Trp Ser Pro Cys Leu Pro Ala 
                85                  90                  95      


Val Ala Pro Leu Val Leu Gly Ser Leu Ala His Pro Leu Pro Leu Gln 
            100                 105                 110         


Gly Ala Val Leu Gly Gly Val Gly Ser Val Leu Phe Leu Ala Gly Arg 
        115                 120                 125             


Asn Gly Val Pro Lys Arg Gly Ser Leu Val Gly Leu Ala Pro Pro Ser 
    130                 135                 140                 


Pro Ala Pro Met Ser Ala Arg Ala Pro Lys Glu Leu Arg Leu Ala Leu 
145                 150                 155                 160 


Pro Pro Cys Leu Leu Asn Arg Thr Phe Ala Ser Pro Asn Ala Ser Gly 
                165                 170                 175     


Ser Gly Asn Thr Gly Ala Arg Gly Pro Gly Ala Val Gly Ser Gly Thr 
            180                 185                 190         


Cys Ile Thr Gln Val Gly Gln Gln Leu Phe Gln Ser Phe Ser Ser Thr 
        195                 200                 205             


Leu Val Leu Ile Val Leu Val Thr Leu Ile Phe Cys Leu Ile Val Leu 
    210                 215                 220                 


Ser Leu Ser Thr Phe His Ile His Lys Arg Arg Met Lys Lys Arg Lys 
225                 230                 235                 240 


Met Gln Arg Ala Gln Glu Glu Tyr Glu Arg Asp His Cys Ser Gly Ser 
                245                 250                 255     


Arg Gly Gly Gly Gly Leu Pro Arg Pro Gly Arg Gln Ala Pro Thr His 
            260                 265                 270         


Ala Lys Glu Thr Arg Leu Glu Arg Gln Pro Arg Asp Ser Pro Phe Cys 
        275                 280                 285             


Ala Pro Ser Asn Ala Ser Ser Leu Ser Ser Ser Ser Pro Gly Leu Pro 
    290                 295                 300                 


Cys Gln Gly Pro Cys Ala Pro Pro Pro Pro Pro Pro Ala Ser Ser Pro 
305                 310                 315                 320 


Gln Gly Ala His Ala Ala Ser Ser Cys Leu Asp Thr Ala Gly Glu Gly 
                325                 330                 335     


Leu Leu Gln Thr Val Val Leu Ser 
            340                 


<210>  1315
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C11orf95__Homo_sapiens__NP_001138408

<400>  1315

Met Glu Pro Gly Gly Asp His Arg Ser Arg Ser Ser Gly Gly Arg Gly 
1               5                   10                  15      


Gly Pro Gly Pro Ala Val Ala Ser Ala Arg Gly Arg Arg Leu Pro Pro 
            20                  25                  30          


Ala Gly Ser Ser Gly Ser Ala Glu Pro Glu Glu Asp Glu Gly Gly Gln 
        35                  40                  45              


Asp Leu Gln Leu Glu Gly Gly Ala Leu Gly Ser Trp Gly Ser Ala Pro 
    50                  55                  60                  


Leu Pro Ser Ser Arg Ala Arg Gly Pro Ala Ser Ser Gly Arg Lys Tyr 
65                  70                  75                  80  


Ser Asp His Cys Glu Ala Arg Ala Ser Arg Pro Gly Lys Ser Arg Ile 
                85                  90                  95      


Pro Gly Arg Asp His Arg Arg Tyr Tyr His Asp His Trp Arg Leu Glu 
            100                 105                 110         


Tyr Leu Met Asp Phe Asn Pro Ala Arg His Gly Met Val Cys Met Val 
        115                 120                 125             


Cys Gly Ser Ser Leu Ala Thr Leu Lys Leu Ser Thr Ile Lys Arg His 
    130                 135                 140                 


Ile Arg Gln Lys His Pro Tyr Ser Leu His Trp Ser Pro Arg Glu Lys 
145                 150                 155                 160 


Glu Val Ile Ser Asn Ser Trp Asp Ala His Leu Gly Leu Gly Ala Cys 
                165                 170                 175     


Gly Glu Ala Glu Gly Leu Gly Val Gln Gly Ala Glu Glu Glu Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Val Pro Ala Cys Pro 
        195                 200                 205             


Pro Lys Gly Pro Gly Lys Ala Pro Ala Gly Gly Gly Cys Arg Arg Gln 
    210                 215                 220                 


Arg Arg Gly Gly Pro Val Ala Pro Arg Ala Arg Arg Leu Arg Leu Ser 
225                 230                 235                 240 


Ala Ser Arg Arg Ala Gly Gly Ser Arg Gly Leu Gly Ala Arg Arg Leu 
                245                 250                 255     


Glu Arg Arg Leu Lys Glu Ser Leu Gln Asn Trp Phe Arg Ala Glu Cys 
            260                 265                 270         


Leu Met Asp Tyr Asp Pro Arg Gly Asn Arg Leu Val Cys Met Ala Cys 
        275                 280                 285             


Gly Arg Ala Leu Pro Ser Leu His Leu Asp Asp Ile Arg Ala His Val 
    290                 295                 300                 


Leu Glu Val His Pro Gly Ser Leu Gly Leu Ser Gly Pro Gln Arg Ser 
305                 310                 315                 320 


Ala Leu Leu Gln Ala Trp Gly Gly Gln Pro Glu Ala Leu Ser Glu Leu 
                325                 330                 335     


Thr Gln Ser Pro Pro Gly Asp Asp Leu Ala Pro Gln Asp Leu Thr Gly 
            340                 345                 350         


Lys Ser Arg Asp Ser Ala Ser Ala Ala Gly Ala Pro Ser Ser Gln Asp 
        355                 360                 365             


Leu Ser Pro Pro Asp Val Lys Glu Glu Ala Gly Trp Val Pro Glu Arg 
    370                 375                 380                 


Pro Gly Pro Ala Glu Glu Glu Glu Glu Leu Glu Glu Gly Glu Gly Glu 
385                 390                 395                 400 


Arg Ala Gly Val Pro Gly Arg Ser Pro Arg Gly Arg Ala His Arg Arg 
                405                 410                 415     


His Pro Gln Glu Arg Trp Arg Leu Glu Tyr Leu Met Glu Leu Asp Gly 
            420                 425                 430         


Gly Arg Arg Gly Leu Val Cys Gly Val Cys Gly Gly Ala Leu Ala Ser 
        435                 440                 445             


Leu Lys Met Ser Thr Ile Glu Arg His Ile Arg Arg Arg His Pro Gly 
    450                 455                 460                 


Ser Thr Arg Leu Gly Gly Pro Val Gln Ala Leu Ile Ala Arg Glu Trp 
465                 470                 475                 480 


Ser Glu Lys Ala Ala His Leu Leu Ala Leu Gly Pro Pro Arg Pro Glu 
                485                 490                 495     


Ser Pro Gln Gly Pro Ile Pro Pro Gly Thr Ala Ala Ala Ser Asp Glu 
            500                 505                 510         


Gly Gly Gly Asp Glu Glu Glu Glu Pro Glu Glu Glu Glu Glu Glu Trp 
        515                 520                 525             


Gly Asp Val Pro Leu Ser Pro Gly Ala Pro Leu Glu Arg Pro Ala Glu 
    530                 535                 540                 


Glu Glu Glu Asp Glu Glu Asp Gly Gln Glu Pro Gly Gly Leu Ala Leu 
545                 550                 555                 560 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Arg Ser Arg Glu 
                565                 570                 575     


Gln Arg Arg Asn Tyr Gln Pro Arg Trp Arg Gly Glu Tyr Leu Met Asp 
            580                 585                 590         


Tyr Asp Gly Ser Arg Arg Gly Leu Val Cys Met Val Cys Gly Gly Ala 
        595                 600                 605             


Leu Ala Thr Leu Lys Val Ser Thr Ile Lys Arg His Ile Leu Gln Val 
    610                 615                 620                 


His Pro Phe Ser Met Asp Phe Thr Pro Glu Glu Arg Gln Thr Ile Leu 
625                 630                 635                 640 


Glu Ala Tyr Glu Glu Ala Ala Leu Arg Cys Tyr Gly His Glu Gly Phe 
                645                 650                 655     


Gly Pro Pro Ala Pro Ala Pro Arg Asp Gly Gly Ala Asp Leu Lys Ser 
            660                 665                 670         


Gly Ala Val Cys Arg Ala 
        675             


<210>  1316
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf10__Homo_sapiens__NP_067653

<400>  1316

Met Gly His Gln Phe Leu Arg Gly Leu Leu Thr Leu Leu Leu Pro Pro 
1               5                   10                  15      


Pro Pro Leu Tyr Thr Arg His Arg Met Leu Gly Pro Glu Ser Val Pro 
            20                  25                  30          


Pro Pro Lys Arg Ser Arg Ser Lys Leu Met Ala Pro Pro Arg Ile Gly 
        35                  40                  45              


Thr His Asn Gly Thr Phe His Cys Asp Glu Ala Leu Ala Cys Ala Leu 
    50                  55                  60                  


Leu Arg Leu Leu Pro Glu Tyr Arg Asp Ala Glu Ile Val Arg Thr Arg 
65                  70                  75                  80  


Asp Pro Glu Lys Leu Ala Ser Cys Asp Ile Val Val Asp Val Gly Gly 
                85                  90                  95      


Glu Tyr Asp Pro Arg Arg His Arg Tyr Asp His His Gln Arg Ser Phe 
            100                 105                 110         


Thr Glu Thr Met Ser Ser Leu Ser Pro Gly Lys Pro Trp Gln Thr Lys 
        115                 120                 125             


Leu Ser Ser Ala Gly Leu Ile Tyr Leu His Phe Gly His Lys Leu Leu 
    130                 135                 140                 


Ala Gln Leu Leu Gly Thr Ser Glu Glu Asp Ser Met Val Gly Thr Leu 
145                 150                 155                 160 


Tyr Asp Lys Met Tyr Glu Asn Phe Val Glu Glu Val Asp Ala Val Asp 
                165                 170                 175     


Asn Gly Ile Ser Gln Trp Ala Glu Gly Glu Pro Arg Tyr Ala Leu Thr 
            180                 185                 190         


Thr Thr Leu Ser Ala Arg Val Ala Arg Leu Asn Pro Thr Trp Asn His 
        195                 200                 205             


Pro Asp Gln Asp Thr Glu Ala Gly Phe Lys Arg Ala Met Asp Leu Val 
    210                 215                 220                 


Gln Glu Glu Phe Leu Gln Arg Leu Asp Phe Tyr Gln His Ser Trp Leu 
225                 230                 235                 240 


Pro Ala Arg Ala Leu Val Glu Glu Ala Leu Ala Gln Arg Phe Gln Val 
                245                 250                 255     


Asp Pro Ser Gly Glu Ile Val Glu Leu Ala Lys Gly Ala Cys Pro Trp 
            260                 265                 270         


Lys Glu His Leu Tyr His Leu Glu Ser Gly Leu Ser Pro Pro Val Ala 
        275                 280                 285             


Ile Phe Phe Val Ile Tyr Thr Asp Gln Ala Gly Gln Trp Arg Ile Gln 
    290                 295                 300                 


Cys Val Pro Lys Glu Pro His Ser Phe Gln Ser Arg Leu Pro Leu Pro 
305                 310                 315                 320 


Glu Pro Trp Arg Gly Leu Arg Asp Glu Ala Leu Asp Gln Val Ser Gly 
                325                 330                 335     


Ile Pro Gly Cys Ile Phe Val His Ala Ser Gly Phe Ile Gly Gly His 
            340                 345                 350         


His Thr Arg Glu Gly Ala Leu Ser Met Ala Arg Ala Thr Leu Ala Gln 
        355                 360                 365             


Arg Ser Tyr Leu Pro Gln Ile Ser 
    370                 375     


<210>  1317
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf42__Homo_sapiens__NP_940923

<400>  1317

Met Ser Thr Val Ile Cys Met Lys Gln Arg Glu Glu Glu Phe Leu Leu 
1               5                   10                  15      


Thr Ile Arg Pro Phe Ala Asn Arg Met Gln Lys Ser Pro Cys Tyr Ile 
            20                  25                  30          


Pro Ile Val Ser Ser Ala Thr Leu Trp Asp Arg Ser Thr Pro Ser Ala 
        35                  40                  45              


Lys His Ile Pro Cys Tyr Glu Arg Thr Ser Val Pro Cys Ser Arg Phe 
    50                  55                  60                  


Ile Asn His Met Lys Asn Phe Ser Glu Ser Pro Lys Phe Arg Ser Leu 
65                  70                  75                  80  


His Phe Leu Asn Phe Pro Val Phe Pro Glu Arg Thr Gln Asn Ser Met 
                85                  90                  95      


Ala Cys Lys Arg Leu Leu His Thr Cys Gln Tyr Ile Val Pro Arg Cys 
            100                 105                 110         


Ser Val Ser Thr Val Ser Phe Asp Glu Glu Ser Tyr Glu Glu Phe Arg 
        115                 120                 125             


Ser Ser Pro Ala Pro Ser Ser Glu Thr Asp Glu Ala Pro Leu Ile Phe 
    130                 135                 140                 


Thr Ala Arg Gly Glu Thr Glu Glu Arg Ala Arg Gly Ala Pro Lys Gln 
145                 150                 155                 160 


Ala Trp Asn Ser Ser Phe Leu Glu Gln Leu Val Lys Lys Pro Asn Trp 
                165                 170                 175     


Ala His Ser Val Asn Pro Val His Leu Glu Ala Gln Gly Ile His Ile 
            180                 185                 190         


Ser Arg His Thr Arg Pro Lys Gly Gln Pro Leu Ser Ser Pro Lys Lys 
        195                 200                 205             


Asn Ser Gly Ser Ala Ala Arg Pro Ser Thr Ala Ile Gly Leu Cys Arg 
    210                 215                 220                 


Arg Ser Gln Thr Pro Gly Ala Leu Gln Ser Thr Gly Pro Ser Asn Thr 
225                 230                 235                 240 


Glu Leu Glu Pro Glu Glu Arg Met Ala Val Pro Ala Gly Ala Gln Ala 
                245                 250                 255     


His Pro Asp Asp Ile Gln Ser Arg Leu Leu Gly Ala Ser Gly Asn Pro 
            260                 265                 270         


Val Gly Lys Gly Ala Val Ala Met Ala Pro Glu Met Leu Pro Lys His 
        275                 280                 285             


Pro His Thr Pro Arg Asp Arg Arg Pro Gln Ala Asp Thr Ser Leu His 
    290                 295                 300                 


Gly Asn Leu Ala Gly Ala Pro Leu Pro Leu Leu Ala Gly Ala Ser Thr 
305                 310                 315                 320 


His Phe Pro Ser Lys Arg Leu Ile Lys Val Cys Ser Ser Ala Pro Pro 
                325                 330                 335     


Arg Pro Thr Arg Arg Phe His Thr Val Cys Ser Gln Ala Leu Ser Arg 
            340                 345                 350         


Pro Val Val Asn Ala His Leu His 
        355                 360 


<210>  1318
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf43__Homo_sapiens__NP_001273127

<400>  1318

Met Phe Cys Gln Asn Pro Gly Ala Ala Asn Ser Gln Leu Ser Thr Ser 
1               5                   10                  15      


Gln Pro Ser Leu Arg His Lys Val Asn Glu His Glu Gln Asp Gly Asn 
            20                  25                  30          


Glu Leu Gln Thr Thr Pro Glu Phe Arg Ala His Val Ala Lys Lys Leu 
        35                  40                  45              


Gly Ala Leu Leu Asp Ser Phe Ile Thr Ile Ser Glu Ala Ala Lys Glu 
    50                  55                  60                  


Pro Ala Lys Ala Lys Val Gln Lys Val Ala Leu Glu Asp Asp Gly Phe 
65                  70                  75                  80  


Arg Leu Phe Phe Thr Ser Val Pro Gly Gly Arg Glu Lys Glu Glu Ser 
                85                  90                  95      


Pro Gln Pro Arg Arg Lys Arg Gln Pro Ser Ser Ser Ser Ser Glu Asp 
            100                 105                 110         


Ser Asp Glu Glu Trp Arg Arg Cys Arg Glu Ala Ala Val Ser Ala Ser 
        115                 120                 125             


Asp Ile Leu Gln Glu Ser Ala Ile His Ser Pro Gly Thr Val Glu Lys 
    130                 135                 140                 


Glu Ala Lys Lys Lys Arg Lys Leu Lys Lys Lys Ala Lys Lys Val Ala 
145                 150                 155                 160 


Ser Val Asp Ser Ala Val Ala Ala Thr Thr Pro Thr Ser Met Ala Thr 
                165                 170                 175     


Val Gln Lys Gln Lys Ser Gly Glu Leu Asn Gly Asp Gln Val Ser Leu 
            180                 185                 190         


Gly Thr Lys Lys Lys Lys Lys Ala Lys Lys Ala Ser Glu Thr Ser Pro 
        195                 200                 205             


Phe Pro Pro Ala Lys Ser Ala Thr Ala Ile Pro Ala Asn 
    210                 215                 220     


<210>  1319
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf50__Homo_sapiens__NP_689802

<400>  1319

Met Glu Met Gln Gln Asn Cys Ser Ile Ser Cys Phe Trp Glu Thr Gln 
1               5                   10                  15      


Pro Leu Gly Cys Val Lys Ile Ser Cys Ile Phe Tyr His Ser Lys Pro 
            20                  25                  30          


Arg Asn Ile Asn Gly Leu Phe Leu Pro Pro Ser Ser Asn Ile Thr Leu 
        35                  40                  45              


Gln Lys Glu Ile Gln Glu Gly Ile Pro Leu Gln Ser Gln Ser Gln Glu 
    50                  55                  60                  


Pro Leu Lys Pro Gln Glu Asn Ile Ser Arg Pro Ile His His Pro Leu 
65                  70                  75                  80  


Val Leu Lys Thr Asn Phe Glu Glu Glu Glu Glu Val Asp Glu Gln Asn 
                85                  90                  95      


Asp Ala Ser Ser Leu Trp Thr Lys Thr Pro Glu Glu Ile Glu Glu Lys 
            100                 105                 110         


Arg Ala Ile Lys Glu Met Cys Tyr Lys Ser Gly Glu Tyr Tyr Arg Phe 
        115                 120                 125             


His Thr Pro Pro Asp Ile Leu Ser Ser Lys Ser Met Thr Pro Thr Ala 
    130                 135                 140                 


Glu Lys Gln Leu Glu Lys Pro Leu Glu Asn Gly Ser Glu Leu Gln Glu 
145                 150                 155                 160 


Gly Asp Ser Leu Thr Val Pro Thr Lys Leu Ser Gln Tyr Glu Arg Gln 
                165                 170                 175     


Gly Glu Ile Lys Thr Ser Leu His Gly Lys Pro Lys Thr Asp Ile Ala 
            180                 185                 190         


Ala Phe Glu Asn Gly Gly Gly Asp Cys Tyr Val Pro Gln Arg Val Ile 
        195                 200                 205             


Phe Leu Gly Val Asp Glu Ser Glu Ala Leu Thr Glu Glu Lys Glu Ile 
    210                 215                 220                 


Thr Ile Ser Lys Cys Ser Asn Thr Lys Asp Asn Lys Asp Ser Pro His 
225                 230                 235                 240 


Pro Lys His Ser Leu Thr Thr Arg Leu Val Pro Thr Thr His Val Leu 
                245                 250                 255     


Asn Ala Thr Glu Asn Ile Ser Met Lys Cys Arg Glu Asp Pro Ser Ser 
            260                 265                 270         


Met Asn Asp Val Gln Pro Val Lys Lys Pro His Phe Lys Gly Val Lys 
        275                 280                 285             


Lys Arg Lys Trp Ile Tyr Asp Glu Pro Gln Asn Phe Pro Asn Ser Gly 
    290                 295                 300                 


Met Gln Arg Ala Val Gln Ala Pro Arg Pro Gln Asn Lys Met Ser Tyr 
305                 310                 315                 320 


His Arg Asn Asn Lys Asn Arg Asn Ala Glu Asn Ala Ser Tyr Ile His 
                325                 330                 335     


Val Gln Arg Asp Ala Val Arg Thr Val Ala Leu Asn Ala Pro Ser Arg 
            340                 345                 350         


Ser Arg Pro Thr His Gly Ser Tyr Asn Lys Val His Ala Asn Arg Glu 
        355                 360                 365             


Pro Lys Pro Asn Leu Ser Pro Asp Lys Tyr Thr Ser Thr Ser Tyr Asn 
    370                 375                 380                 


Asp Ser Ala Trp Arg Lys Arg Ile Pro Phe Ser Lys Thr Tyr Ser Lys 
385                 390                 395                 400 


Ser Glu Lys Ile Tyr Pro Glu Pro Arg Arg Asn Gly Ser Lys 
                405                 410                 


<210>  1320
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf57__Homo_sapiens__NP_001288763

<400>  1320

Met Ala Ser Ala Ser Thr Gln Pro Ala Ala Leu Ser Ala Glu Gln Ala 
1               5                   10                  15      


Lys Val Val Leu Ala Glu Val Ile Gln Ala Phe Ser Ala Pro Glu Asn 
            20                  25                  30          


Ala Val Arg Met Asp Glu Ala Arg Asp Asn Ala Cys Asn Asp Met Gly 
        35                  40                  45              


Lys Met Leu Gln Phe Val Leu Pro Val Ala Thr Gln Ile Gln Gln Glu 
    50                  55                  60                  


Val Ile Lys Ala Tyr Gly Phe Ser Cys Asp Gly Glu Gly Val Leu Lys 
65                  70                  75                  80  


Phe Ala Arg Leu Val Lys Ser Tyr Glu Ala Gln Asp Pro Glu Ile Ala 
                85                  90                  95      


Ser Leu Ser Gly Lys Leu Lys Ala Leu Phe Leu Pro Pro Met Thr Leu 
            100                 105                 110         


Pro Pro His Gly Pro Ala Ala Gly Gly Ser Val Ala Ala Ser 
        115                 120                 125     


<210>  1321
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf5__Homo_sapiens__NP_065108

<400>  1321

Met Ala Arg Phe Ala Leu Thr Val Val Arg His Gly Glu Thr Arg Phe 
1               5                   10                  15      


Asn Lys Glu Lys Ile Ile Gln Gly Gln Gly Val Asp Glu Pro Leu Ser 
            20                  25                  30          


Glu Thr Gly Phe Lys Gln Ala Ala Ala Ala Gly Ile Phe Leu Asn Asn 
        35                  40                  45              


Val Lys Phe Thr His Ala Phe Ser Ser Asp Leu Met Arg Thr Lys Gln 
    50                  55                  60                  


Thr Met His Gly Ile Leu Glu Arg Ser Lys Phe Cys Lys Asp Met Thr 
65                  70                  75                  80  


Val Lys Tyr Asp Ser Arg Leu Arg Glu Arg Lys Tyr Gly Val Val Glu 
                85                  90                  95      


Gly Lys Ala Leu Ser Glu Leu Arg Ala Met Ala Lys Ala Ala Arg Glu 
            100                 105                 110         


Glu Cys Pro Val Phe Thr Pro Pro Gly Gly Glu Thr Leu Asp Gln Val 
        115                 120                 125             


Lys Met Arg Gly Ile Asp Phe Phe Glu Phe Leu Cys Gln Leu Ile Leu 
    130                 135                 140                 


Lys Glu Ala Asp Gln Lys Glu Gln Phe Ser Gln Gly Ser Pro Ser Asn 
145                 150                 155                 160 


Cys Leu Glu Thr Ser Leu Ala Glu Ile Phe Pro Leu Gly Lys Asn His 
                165                 170                 175     


Ser Ser Lys Val Asn Ser Asp Ser Gly Ile Pro Gly Leu Ala Ala Ser 
            180                 185                 190         


Val Leu Val Val Ser His Gly Ala Tyr Met Arg Ser Leu Phe Asp Tyr 
        195                 200                 205             


Phe Leu Thr Asp Leu Lys Cys Ser Leu Pro Ala Thr Leu Ser Arg Ser 
    210                 215                 220                 


Glu Leu Met Ser Val Thr Pro Asn Thr Gly Met Ser Leu Phe Ile Ile 
225                 230                 235                 240 


Asn Phe Glu Glu Gly Arg Glu Val Lys Pro Thr Val Gln Cys Ile Cys 
                245                 250                 255     


Met Asn Leu Gln Asp His Leu Asn Gly Leu Thr Glu Thr Arg 
            260                 265                 270 


<210>  1322
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf65__Homo_sapiens__NP_001181924

<400>  1322

Met Ser Thr Val Gly Leu Phe His Phe Pro Thr Pro Leu Thr Arg Ile 
1               5                   10                  15      


Cys Pro Ala Pro Trp Gly Leu Arg Leu Trp Glu Lys Leu Thr Leu Leu 
            20                  25                  30          


Ser Pro Gly Ile Ala Val Thr Pro Val Gln Met Ala Gly Lys Lys Asp 
        35                  40                  45              


Tyr Pro Ala Leu Leu Ser Leu Asp Glu Asn Glu Leu Glu Glu Gln Phe 
    50                  55                  60                  


Val Lys Gly His Gly Pro Gly Gly Gln Ala Thr Asn Lys Thr Ser Asn 
65                  70                  75                  80  


Cys Val Val Leu Lys His Ile Pro Ser Gly Ile Val Val Lys Cys His 
                85                  90                  95      


Gln Thr Arg Ser Val Asp Gln Asn Arg Lys Leu Ala Arg Lys Ile Leu 
            100                 105                 110         


Gln Glu Lys Val Asp Val Phe Tyr Asn Gly Glu Asn Ser Pro Val His 
        115                 120                 125             


Lys Glu Lys Arg Glu Ala Ala Lys Lys Lys Gln Glu Arg Lys Lys Arg 
    130                 135                 140                 


Ala Lys Glu Thr Leu Glu Lys Lys Lys Leu Leu Lys Glu Leu Trp Glu 
145                 150                 155                 160 


Ser Ser Lys Lys Val His 
                165     


<210>  1323
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf66__Homo_sapiens__NP_001287869

<400>  1323

Met Gly Glu Ser Ile Pro Leu Ala Ala Pro Val Pro Val Glu Gln Ala 
1               5                   10                  15      


Val Leu Glu Thr Phe Phe Ser His Leu Gly Ile Phe Ser Tyr Asp Lys 
            20                  25                  30          


Ala Lys Asp Asn Val Glu Lys Glu Arg Glu Ala Asn Lys Ser Ala Gly 
        35                  40                  45              


Gly Ser Trp Leu Ser Leu Leu Ala Ala Leu Ala His Leu Ala Ala Ala 
    50                  55                  60                  


Glu Lys Val Tyr His Ser Leu Thr Tyr Leu Gly Gln Lys Leu Gly Gly 
65                  70                  75                  80  


Gln Ser Phe Phe Ser Arg Lys Asp Ser Ile Arg Thr Ile Tyr Thr Ser 
                85                  90                  95      


Leu His Asn Glu Leu Lys Lys Val Val Thr Gly Arg Gly Ala Leu Gly 
            100                 105                 110         


Gly Thr Ala Pro His Val Glu Glu Leu Leu Ser His Leu Ser Glu Gln 
        115                 120                 125             


Leu Cys Phe Phe Val Gln Ala Arg Met Glu Ile Ala Asp Phe Tyr Glu 
    130                 135                 140                 


Lys Met Tyr Thr Leu Ser Thr Gln Lys Phe Ile Asn Ala Glu Glu Leu 
145                 150                 155                 160 


Val Gly Leu Leu Asp Ala Ile Met Lys Lys Tyr Ser Ser Arg Phe His 
                165                 170                 175     


His Pro Ile Leu Ser Pro Leu Glu Ser Ser Phe Gln Leu Glu Val Asp 
            180                 185                 190         


Val Leu Cys His Leu Leu Lys Ala Gln Ala Gln Val Ser Glu Trp Lys 
        195                 200                 205             


Phe Leu Pro Ser Leu Val Asn Leu His Ser Ala His Thr Lys Leu Gln 
    210                 215                 220                 


Thr Trp Gly Gln Ile Phe Glu Lys Gln Arg Glu Thr Lys Lys His Leu 
225                 230                 235                 240 


Phe Gly Gly Gln Ser Gln Lys Ala Val Gln Pro Pro His Leu Phe Leu 
                245                 250                 255     


Trp Leu Met Lys Leu Lys Asn Met Leu Leu Ala Lys Phe Ser Phe Tyr 
            260                 265                 270         


Phe His Glu Ala Leu Ser Arg Gln Thr Thr Ala Ser Glu Met Lys Thr 
        275                 280                 285             


Leu Thr Ala Lys Ala Asn Pro Asp Phe Phe Gly Lys Ile Ser Ser Phe 
    290                 295                 300                 


Ile Arg Lys Tyr Asp Ala Ala Asn Val Ser Leu Ile Phe Asp Asn Arg 
305                 310                 315                 320 


Gly Ser Glu Ser Phe Gln Gly His Gly Tyr His His Pro His Ser Tyr 
                325                 330                 335     


Arg Glu Ala Pro Lys Gly Val Asp Gln Tyr Pro Ala Val Val Ser Leu 
            340                 345                 350         


Pro Ser Asp Arg Pro Val Met His Trp Pro Asn Val Ile Met Ile Met 
        355                 360                 365             


Thr Asp Arg Thr Ser Asp Leu Asn Ser Leu Glu Lys Val Val His Phe 
    370                 375                 380                 


Tyr Asp Asp Lys Val Gln Ser Thr Tyr Phe Leu Thr Arg Pro Glu Pro 
385                 390                 395                 400 


His Phe Thr Ile Val Ile Ile Phe Glu Ser Lys Lys Ser Glu Arg Asp 
                405                 410                 415     


Ser His Phe Ile Ser Phe Leu Asn Glu Val Ser Leu Ala Leu Lys Asn 
            420                 425                 430         


Pro Lys Val Phe Ala Ser Leu Lys Pro Gly Ser Lys Gly Ser Cys Tyr 
        435                 440                 445             


Gln Cys Asn Tyr Phe Val Ala Phe Cys Leu Asn Tyr Ser Lys Leu Leu 
    450                 455                 460                 


Leu Gln Arg Lys 
465             


<210>  1324
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf75__Homo_sapiens__NP_001138671

<400>  1324

Met Gly Cys Gly Asn Ser Thr Ala Thr Ser Ala Gly Ala Gly Gln Gly 
1               5                   10                  15      


Pro Ala Gly Ala Ala Lys Asp Val Thr Glu Glu Ser Val Thr Glu Asp 
            20                  25                  30          


Asp Lys Arg Arg Asn Tyr Gly Gly Val Tyr Val Gly Leu Pro Ser Glu 
        35                  40                  45              


Ala Val Asn Met Val Ser Ser Gln Thr Lys Thr Val Arg Lys Asn 
    50                  55                  60              


<210>  1325
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12orf77__Homo_sapiens__NP_001094809

<400>  1325

Met Ile Pro Lys Leu Ala Thr Pro Arg Asp Ile Ser Leu Leu Val Ile 
1               5                   10                  15      


Lys Glu Ala Ser Ser Arg Ala Arg Asn Asn Ile Gln Ile Leu Asp Pro 
            20                  25                  30          


Leu Asp His Ile Ala Arg Leu Thr Asn Tyr Thr Leu Thr Ser Cys Phe 
        35                  40                  45              


Ser Ser Asn Lys Val Pro Thr Met Pro Gly Ser Leu Pro Thr Gly Ser 
    50                  55                  60                  


Lys Gln Gly Asn Val Gln Thr Leu Asp Ser Ile Arg Trp Met Pro Ala 
65                  70                  75                  80  


Thr Pro Val Pro Ala Pro Glu Cys His Gln Lys Tyr Ala Ile Ser Thr 
                85                  90                  95      


Glu Thr Ala Phe Pro Thr Leu Ser Thr Phe Met Asn Thr Glu Lys Ser 
            100                 105                 110         


Val Lys Gly Ser Asn Ala Asp Phe Thr Lys Arg Asn Pro Arg Trp Arg 
        115                 120                 125             


Phe Leu Phe Gly Ile Tyr Cys Ser Leu His His Ala Met Thr Ile Phe 
    130                 135                 140                 


Ile 
145 


<210>  1326
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C14orf166__Homo_sapiens__NP_057123

<400>  1326

Met Phe Arg Arg Lys Leu Thr Ala Leu Asp Tyr His Asn Pro Ala Gly 
1               5                   10                  15      


Phe Asn Cys Lys Asp Glu Thr Glu Phe Arg Asn Phe Ile Val Trp Leu 
            20                  25                  30          


Glu Asp Gln Lys Ile Arg His Tyr Lys Ile Glu Asp Arg Gly Asn Leu 
        35                  40                  45              


Arg Asn Ile His Ser Ser Asp Trp Pro Lys Phe Phe Glu Lys Tyr Leu 
    50                  55                  60                  


Arg Asp Val Asn Cys Pro Phe Lys Ile Gln Asp Arg Gln Glu Ala Ile 
65                  70                  75                  80  


Asp Trp Leu Leu Gly Leu Ala Val Arg Leu Glu Tyr Gly Asp Asn Ala 
                85                  90                  95      


Glu Lys Tyr Lys Asp Leu Val Pro Asp Asn Ser Lys Thr Ala Asp Asn 
            100                 105                 110         


Ala Thr Lys Asn Ala Glu Pro Leu Ile Asn Leu Asp Val Asn Asn Pro 
        115                 120                 125             


Asp Phe Lys Ala Gly Val Met Ala Leu Ala Asn Leu Leu Gln Ile Gln 
    130                 135                 140                 


Arg His Asp Asp Tyr Leu Val Met Leu Lys Ala Ile Arg Ile Leu Val 
145                 150                 155                 160 


Gln Glu Arg Leu Thr Gln Asp Ala Val Ala Lys Ala Asn Gln Thr Lys 
                165                 170                 175     


Glu Gly Leu Pro Val Ala Leu Asp Lys His Ile Leu Gly Phe Asp Thr 
            180                 185                 190         


Gly Asp Ala Val Leu Asn Glu Ala Ala Gln Ile Leu Arg Leu Leu His 
        195                 200                 205             


Ile Glu Glu Leu Arg Glu Leu Gln Thr Lys Ile Asn Glu Ala Ile Val 
    210                 215                 220                 


Ala Val Gln Ala Ile Ile Ala Asp Pro Lys Thr Asp His Arg Leu Gly 
225                 230                 235                 240 


Lys Val Gly Arg 
                


<210>  1327
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C14orf177__Homo_sapiens__NP_872366

<400>  1327

Met His Arg Lys Glu Pro Gly Ala Arg Leu Glu Ala Thr Arg Gly Ala 
1               5                   10                  15      


Ala Arg Pro His Lys Gln Gly Thr Lys Pro Met Ile Thr Arg Pro Ser 
            20                  25                  30          


Val Ser Gln Leu Gly Glu Gly Lys Cys Pro Ser Ser Gln His Leu Gln 
        35                  40                  45              


Ser Leu Arg His Asn Lys Gln His Ala Leu Thr Leu Thr Lys Ala Arg 
    50                  55                  60                  


Cys Cys Gly Glu Cys Ser Thr Cys Phe Cys Thr Glu Glu Lys Ser Glu 
65                  70                  75                  80  


Cys Gln Arg His Glu Glu Thr Ser Pro Gly Ser Cys Asn His Gln Ile 
                85                  90                  95      


Met Ser Ala Ser Thr Ile Ser Ala Phe Cys Ala Thr Pro Arg Phe Lys 
            100                 105                 110         


Gln Leu Phe Lys Gly Thr Val Glu Gln Met Ser Gln Met 
        115                 120                 125 


<210>  1328
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C14orf1__Homo_sapiens__NP_009107

<400>  1328

Met Ser Arg Phe Leu Asn Val Leu Arg Ser Trp Leu Val Met Val Ser 
1               5                   10                  15      


Ile Ile Ala Met Gly Asn Thr Leu Gln Ser Phe Arg Asp His Thr Phe 
            20                  25                  30          


Leu Tyr Glu Lys Leu Tyr Thr Gly Lys Pro Asn Leu Val Asn Gly Leu 
        35                  40                  45              


Gln Ala Arg Thr Phe Gly Ile Trp Thr Leu Leu Ser Ser Val Ile Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ile Asp Ile His Asn Lys Thr Leu Tyr His Ile Thr 
65                  70                  75                  80  


Leu Trp Thr Phe Leu Leu Ala Leu Gly His Phe Leu Ser Glu Leu Phe 
                85                  90                  95      


Val Tyr Gly Thr Ala Ala Pro Thr Ile Gly Val Leu Ala Pro Leu Met 
            100                 105                 110         


Val Ala Ser Phe Ser Ile Leu Gly Met Leu Val Gly Leu Arg Tyr Leu 
        115                 120                 125             


Glu Val Glu Pro Val Ser Arg Gln Lys Lys Arg Asn 
    130                 135                 140 


<210>  1329
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C15orf32__Homo_sapiens__NP_694585

<400>  1329

Met Asn Lys Arg Thr Ser Val Asp Ala Ser Lys Glu Asp Leu His Pro 
1               5                   10                  15      


Ala Asp Pro Gln Ser Gly Glu Gly Val Pro Pro Asn Arg Lys Asn Thr 
            20                  25                  30          


Lys Thr Ser Pro Arg Gly Glu Gly Thr Ala Pro Pro Phe Ser Ala Arg 
        35                  40                  45              


Pro Cys Val Trp Thr Leu Cys Glu Met Leu Ser Ile Leu Ala Leu Val 
    50                  55                  60                  


Gly Val Leu His Pro Phe Tyr Arg Ser Asn Asn Gln Val Tyr Gln Lys 
65                  70                  75                  80  


Leu Lys Thr His Leu Arg Cys Gln Ser Ser Arg Val Asp Gly Leu Met 
                85                  90                  95      


Leu Lys Pro Thr Leu Leu Thr Pro Ser Gln Leu Lys Ser Pro Glu Gly 
            100                 105                 110         


His Leu Ile Leu Pro Thr Phe Asn His Leu Val Ile Arg His Ile Leu 
        115                 120                 125             


Asp Pro Lys Gln Ile Phe Cys Val Ala Asp Val Cys Thr Asp Cys Lys 
    130                 135                 140                 


Phe Asn Cys Gly Ser Ile Glu Arg His Gln Lys Arg His Leu Met Arg 
145                 150                 155                 160 


Val Ser Gln Asp Trp Glu His Leu Ile Arg Tyr Arg Asn Gln Ile Cys 
                165                 170                 175     


Leu Ser 
        


<210>  1330
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C15orf41__Homo_sapiens__XP_011520412

<400>  1330

Met Ile Leu Thr Lys Ala Gln Tyr Asp Glu Ile Ala Gln Cys Leu Val 
1               5                   10                  15      


Ser Val Pro Pro Thr Arg Gln Ser Leu Arg Lys Leu Lys Gln Arg Phe 
            20                  25                  30          


Pro Ser Gln Ser Gln Ala Thr Leu Leu Ser Ile Phe Ser Gln Glu Tyr 
        35                  40                  45              


Gln Lys His Ile Lys Arg Thr His Ala Lys His His Thr Ser Glu Ala 
    50                  55                  60                  


Ile Glu Ser Tyr Tyr Gln Arg Tyr Leu Asn Gly Val Val Lys Asn Gly 
65                  70                  75                  80  


Ala Ala Pro Val Leu Leu Asp Leu Ala Asn Glu Val Asp Tyr Ala Pro 
                85                  90                  95      


Ser Leu Met Ala Arg Leu Ile Leu Glu Arg Phe Leu Gln Glu His Glu 
            100                 105                 110         


Glu Thr Pro Pro Ser Lys Ser Ile Ile Asn Ser Met Leu Arg Asp Pro 
        115                 120                 125             


Ser Gln Ile Pro Asp Gly Val Leu Ala Asn Gln Val Tyr Gln Cys Ile 
    130                 135                 140                 


Val Asn Asp Cys Cys Tyr Gly Pro Leu Val Asp Cys Ile Lys His Ala 
145                 150                 155                 160 


Ile Gly His Glu His Glu Val Leu Leu Arg Asp Leu Leu Leu Glu Lys 
                165                 170                 175     


Asn Leu Ser Phe Leu Asp Glu Asp Gln Leu Arg Ala Lys Gly Tyr Asp 
            180                 185                 190         


Lys Thr Pro Asp Phe Ile Leu Gln Val Pro Val Ala Val Glu Gly His 
        195                 200                 205             


Ile Ile His Trp Ile Glu Ser Lys Ala Ser Phe Gly Asp Glu Cys Ser 
    210                 215                 220                 


His His Ala Tyr Leu His Asp Gln Phe Trp Ser Tyr Trp Asn Arg Phe 
225                 230                 235                 240 


Gly Pro Gly Leu Val Ile Tyr Trp Tyr Gly Phe Ile Gln Glu Leu Asp 
                245                 250                 255     


Cys Asn Arg Glu Arg Gly Ile Leu Leu Lys Ala Cys Phe Pro Thr Asn 
            260                 265                 270         


Ile Val Thr Leu Cys His Ser Ile Ala 
        275                 280     


<210>  1331
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C15orf48__Homo_sapiens__NP_922946

<400>  1331

Met Ser Phe Phe Gln Leu Leu Met Lys Arg Lys Glu Leu Ile Pro Leu 
1               5                   10                  15      


Val Val Phe Met Thr Val Ala Ala Gly Gly Ala Ser Ser Phe Ala Val 
            20                  25                  30          


Tyr Ser Leu Trp Lys Thr Asp Val Ile Leu Asp Arg Lys Lys Asn Pro 
        35                  40                  45              


Glu Pro Trp Glu Thr Val Asp Pro Thr Val Pro Gln Lys Leu Ile Thr 
    50                  55                  60                  


Ile Asn Gln Gln Trp Lys Pro Ile Glu Glu Leu Gln Asn Val Gln Arg 
65                  70                  75                  80  


Val Thr Lys 
            


<210>  1332
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C15orf53__Homo_sapiens__NP_997327

<400>  1332

Met Glu Leu Gln Gly Ala Gln Glu Asp Leu Gly Ile Ser Leu Ser Ser 
1               5                   10                  15      


Pro Arg Arg Asn His Glu Thr Arg Pro Gly Ser Lys Ala Lys Gly Arg 
            20                  25                  30          


Ser Ser Ile Cys Leu Gln Ala Ser Val Trp Met Ala Gly Gly Lys Leu 
        35                  40                  45              


Arg Leu Arg Ala Ser Glu His Leu Thr Gln Gly His Gln Gln Glu Leu 
    50                  55                  60                  


Arg Asp Trp Asn Leu Gly Glu Asp Ala Ser Leu Leu Phe Ser Lys Ser 
65                  70                  75                  80  


Pro Phe Gly Ala Gly Lys Leu Ile Gln Ala Pro Ala His Val Phe Arg 
                85                  90                  95      


Gln Cys Trp Val Gln Gly Asn Ala Trp Ile Ser Cys Ile Thr Lys Phe 
            100                 105                 110         


Asp Ser Lys Arg Ser Pro Glu Val Ala Ser Ser Pro Ser Tyr Leu Thr 
        115                 120                 125             


Val Pro Arg Arg Ser Pro Leu Pro Val Phe Leu Arg Pro Ser Asp Arg 
    130                 135                 140                 


Cys Val Cys Gly Gly Cys Tyr Leu Gly Lys Ser Thr Arg Arg Arg Ala 
145                 150                 155                 160 


Cys Gln Ser Leu Leu Ser Asp Pro Leu Gly Val Thr Phe Pro Thr Gln 
                165                 170                 175     


Thr Arg Pro 
            


<210>  1333
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C15orf59__Homo_sapiens__XP_005254426

<400>  1333

Met Asn Ile Arg Gly Ala Pro Asp Leu Gly Gln Pro Ser Asp Asp Pro 
1               5                   10                  15      


Ser Ser Gly Gly Glu Arg Glu Arg Ile Arg Gln Arg Met Lys Met Val 
            20                  25                  30          


Ile Gly Gln Leu Glu Gly Ile Leu Arg Glu Leu Lys Glu Val Ala Lys 
        35                  40                  45              


Glu Leu Arg Glu Val Val Ser Gln Ile Asp Lys Leu Thr Ser Asp Phe 
    50                  55                  60                  


Asp Phe Glu Leu Glu Pro Asp Asp Trp Thr Thr Ala Thr Val Ser Ser 
65                  70                  75                  80  


Thr Ser Ser Ser Asp Lys Ala Gly Met Gly Gly Pro Phe Asp Leu Gly 
                85                  90                  95      


His Leu Asp Phe Met Thr Ala Asp Ile Leu Ser Asp Ser Trp Glu Phe 
            100                 105                 110         


Cys Ser Phe Leu Asp Val Ser Thr Pro Ser Asp Ser Val Asp Gly Pro 
        115                 120                 125             


Glu Ser Thr Arg Pro Gly Ala Gly Pro Asp Tyr Arg Leu Met Asn Gly 
    130                 135                 140                 


Gly Thr Pro Ile Pro Asn Gly Pro Arg Val Glu Thr Pro Asp Ser Ser 
145                 150                 155                 160 


Ser Glu Glu Ala Phe Gly Ala Gly Pro Thr Val Lys Ser Gln Leu Pro 
                165                 170                 175     


Gln Arg Thr Pro Gly Thr Arg Glu Arg Val Arg Phe Ser Asp Lys Val 
            180                 185                 190         


Leu Tyr His Ala Leu Cys Cys Asp Asp Glu Glu Gly Asp Gly Glu Gln 
        195                 200                 205             


Glu Val Glu Glu Glu Glu Val Gly Leu Pro Pro Glu Pro Ala His Thr 
    210                 215                 220                 


Glu Ala His Ala Gly Pro His Lys Pro Ser Pro Ala Pro Tyr Lys Ser 
225                 230                 235                 240 


Arg Arg Ser Pro Leu Thr Ser Arg His Ser Gly Ser Thr Leu Ala Pro 
                245                 250                 255     


Glu Gln Thr Arg Arg Val Thr Arg Asn Ser Ser Thr Gln Thr Val Ser 
            260                 265                 270         


Asp Lys Ser Thr Gln Thr Val Leu Pro Tyr Thr Ala Thr Arg Gln Lys 
        275                 280                 285             


Ala Arg Gly Lys Asn 
    290             


<210>  1334
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C16orf72__Homo_sapiens__NP_054836

<400>  1334

Met Glu Glu Arg Lys Glu Glu Gly Glu Ala Glu Ile Gln Glu His Gly 
1               5                   10                  15      


Pro Glu His Trp Phe Ser Lys Trp Glu Arg Gln Cys Leu Ala Glu Ala 
            20                  25                  30          


Glu Gln Asp Glu Gln Leu Pro Pro Glu Leu Gln Glu Glu Ala Ala Ala 
        35                  40                  45              


Ala Ala Gln Pro Glu His Lys Gln Gln Lys Leu Trp His Leu Phe Gln 
    50                  55                  60                  


Asn Ser Ala Thr Ala Val Ala Gln Leu Tyr Lys Asp Arg Val Cys Gln 
65                  70                  75                  80  


Gln Pro Gly Leu Ser Leu Trp Val Pro Phe Gln Asn Ala Ala Thr Ala 
                85                  90                  95      


Val Thr Asn Leu Tyr Lys Glu Ser Val Asp Thr His Gln Arg Ser Phe 
            100                 105                 110         


Asp Ile Gly Ile Gln Ile Gly Tyr Gln Arg Arg Asn Lys Asp Val Leu 
        115                 120                 125             


Ala Trp Val Lys Lys Arg Arg Arg Thr Ile Arg Arg Glu Asp Leu Ile 
    130                 135                 140                 


Ser Phe Leu Cys Gly Lys Val Pro Pro Pro Arg Asn Ser Arg Ala Pro 
145                 150                 155                 160 


Pro Arg Leu Thr Val Val Ser Pro Asn Arg Ala Thr Ser Thr Glu Thr 
                165                 170                 175     


Ser Ser Ser Val Glu Thr Asp Leu Gln Pro Phe Arg Glu Ala Ile Ala 
            180                 185                 190         


Leu His Gly Leu Ser Gly Ala Met Ala Ser Ile Ser Val Arg Ser Ser 
        195                 200                 205             


Thr Pro Gly Ser Pro Thr His Val Ser Ser Gly Ser Asn Ala Ser Arg 
    210                 215                 220                 


Arg Arg Asn Gly Leu His Asp Val Asp Leu Asn Thr Phe Ile Ser Glu 
225                 230                 235                 240 


Glu Met Ala Leu His Leu Asp Asn Gly Gly Thr Arg Lys Arg Thr Ser 
                245                 250                 255     


Ala Gln Cys Gly Asp Val Ile Thr Asp Ser Pro Thr His Lys Arg Asn 
            260                 265                 270         


Arg Met Ile 
        275 


<210>  1335
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C16orf74__Homo_sapiens__NP_996850

<400>  1335

Met Gly Leu Lys Met Ser Cys Leu Lys Gly Phe Gln Met Cys Val Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser His Asp Glu Ala Pro Val Leu Asn Asp Lys His 
            20                  25                  30          


Leu Asp Val Pro Asp Ile Ile Ile Thr Pro Pro Thr Pro Thr Gly Met 
        35                  40                  45              


Met Leu Pro Arg Asp Leu Gly Ser Thr Val Trp Leu Asp Glu Thr Gly 
    50                  55                  60                  


Ser Cys Pro Asp Asp Gly Glu Ile Asp Pro Glu Ala 
65                  70                  75      


<210>  1336
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C16orf78__Homo_sapiens__NP_653203

<400>  1336

Met Ser Glu Gln Gln Met Asp Leu Lys Asp Leu Met Pro Thr Lys Arg 
1               5                   10                  15      


Lys Tyr Met Trp Lys Thr Ala Glu Asp Arg Arg Met Ser Asp Leu Thr 
            20                  25                  30          


Cys Val Leu Glu Trp Leu Glu Arg Arg Gln Gly Lys Lys Lys Gln Ala 
        35                  40                  45              


Pro Glu Lys Gln Lys Pro Lys Val Val Thr Val Leu Lys Arg Asn Lys 
    50                  55                  60                  


Lys Lys Glu Glu Lys Lys Gly Lys Gly Leu Met Thr Ala Arg Gly Gly 
65                  70                  75                  80  


Asn Arg Arg Asp Thr Glu Thr Ser Gln Gln Ala Leu Gly Lys Arg Phe 
                85                  90                  95      


Arg Lys Asp Ala Ala Ser Tyr Arg Ser Leu Tyr Gly Val Glu Gln Lys 
            100                 105                 110         


Gly Lys His Leu Ser Met Val Pro Gly Ser Tyr Ile Lys Asp Gly Pro 
        115                 120                 125             


Lys Lys Ser Asp Thr Asp Ile Lys Asp Ala Val Asp Pro Glu Ser Thr 
    130                 135                 140                 


Gln Arg Pro Asn Pro Phe Arg Arg Gln Ser Ile Val Leu Asp Pro Met 
145                 150                 155                 160 


Leu Gln Glu Gly Thr Phe Asn Ser Gln Arg Ala Thr Phe Ile Arg Asp 
                165                 170                 175     


Trp Ser Asn Lys Met Pro Asp Met Ala Tyr Glu Arg Lys Leu Lys Ser 
            180                 185                 190         


Leu Met Glu Lys Ser Thr Glu Pro Lys Met Glu Thr Met Arg Met Leu 
        195                 200                 205             


Lys Pro Glu Glu Val Leu Ser Cys Arg Tyr Leu Arg Leu Ser Lys Glu 
    210                 215                 220                 


Asn Ile Arg Thr Leu Leu Lys Leu Cys Lys Asp Ala Gly Met Asn Val 
225                 230                 235                 240 


Asp Ile His Pro His Met Val Glu Glu Asp Ile Asp Ala Lys Lys Val 
                245                 250                 255     


Phe Thr Gly Ile Pro Ser Met Ala Leu 
            260                 265 


<210>  1337
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C16orf95__Homo_sapiens__NP_001182053

<400>  1337

Met Arg Ala Ser Arg Ser Pro Pro Ser Pro Arg Arg Cys His His His 
1               5                   10                  15      


His Glu Ala Thr Gly Ala Ala Ser Gly Ala Ala Ala Gly Gly Pro Gly 
            20                  25                  30          


Ala Gly Cys Val Gly Leu Cys Arg Leu Ala Leu Thr Pro Ser Ala Gln 
        35                  40                  45              


Asp Gly Arg Asn Ser Thr Phe Gln Thr Tyr Lys Lys Glu Val Cys Leu 
    50                  55                  60                  


Pro Arg His Ser Met His Pro Gly Pro Trp Ala Ile Cys Cys Glu Cys 
65                  70                  75                  80  


Gln Thr Arg Phe Gly Gly Arg Leu Pro Val Ser Arg Val Glu Ala Ala 
                85                  90                  95      


Leu Pro Tyr Trp Val Pro Leu Ser Leu Arg Pro Arg Lys Gln Ser Gln 
            100                 105                 110         


Lys Thr Val Gln Phe Pro Ile Pro Gln Thr Ala Lys Met Cys Pro Cys 
        115                 120                 125             


Leu Cys His Arg Phe Gly Gly Arg Leu Pro Met Pro Arg Asp Gln Ala 
    130                 135                 140                 


Val Met Pro Tyr Trp Val Pro Gln Val Leu Arg Ser Gln Gln Gln Ile 
145                 150                 155                 160 


Val Arg Arg Gln Gln Ser Leu Lys Gly Ile Gln Ala Pro Leu Leu Asp 
                165                 170                 175     


Ala Cys Cys Trp His Asn Cys Trp Arg Ile Cys Gly Asp Glu Cys Leu 
            180                 185                 190         


Leu Ser Lys Phe Gln Gln Leu Gln Ala Pro Tyr Gln Asp Gln Leu Pro 
        195                 200                 205             


Ala Pro Ala Ala Arg Leu Leu Pro Leu Gly Leu Leu Thr Leu Leu Gln 
    210                 215                 220                 


Ala Ile Pro Arg Val Ile Met Ala Ile Arg Gln Cys Phe Gly Val 
225                 230                 235                 


<210>  1338
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C17orf51__Homo_sapiens__NP_001106905

<400>  1338

Met Gly Glu Lys Ser Arg Arg Lys Gly Pro Ala Pro Arg His Ala Asp 
1               5                   10                  15      


Gly Lys Leu Gly Arg Thr Cys Asp His Pro Tyr Ala Pro Trp Ser Phe 
            20                  25                  30          


Thr Pro Ser Ser Arg Ala Pro Thr Ala Trp Val Arg Pro Pro Cys Pro 
        35                  40                  45              


Val Trp Ala Ser Arg Leu Gln Glu His Ser Pro Glu Pro Arg Arg Ala 
    50                  55                  60                  


Arg Ala Pro Pro Thr Arg Arg Ala Gln Ala Ala Leu Tyr Ala Pro Ala 
65                  70                  75                  80  


Leu Arg Leu Arg Asp His Leu Asp Arg Phe Ser Ile Leu Met Thr Ser 
                85                  90                  95      


Cys Thr Ser Trp Leu Gln Ala Pro Gln Ala Pro Gly Leu Cys Arg Asp 
            100                 105                 110         


Glu Gln Ser Ser Arg Ile Ser Val Pro Gln Leu Ser Gly Ala Pro Ile 
        115                 120                 125             


Leu Leu Pro Asp Leu Glu Gly Thr Lys Leu Ser Asn Phe Gln Glu Ser 
    130                 135                 140                 


Ser Pro Leu Pro His Lys His Glu Arg Lys Asp Lys Arg Ser Thr Pro 
145                 150                 155                 160 


Glu Glu Glu Gly Arg Ser Ala Pro Glu Lys Ile Ile Gln Ser Leu Lys 
                165                 170                 175     


Leu Cys Pro Gly Gly His Arg Pro Ala Ser Leu Ser Ser Gly Cys Pro 
            180                 185                 190         


Ala Gly Cys Arg Leu Ser Phe Asn Leu Pro Pro Ser Met Leu Leu Ser 
        195                 200                 205             


Val Gln Lys Cys Cys Met Pro Ser Ser Leu Lys Thr Cys 
    210                 215                 220     


<210>  1339
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C17orf53__Homo_sapiens__NP_076937

<400>  1339

Met Ala Cys Ser Leu Gln Lys Leu Phe Ala Val Glu Glu Glu Phe Glu 
1               5                   10                  15      


Asp Glu Asp Phe Leu Ser Ala Val Glu Asp Ala Glu Asn Arg Phe Thr 
            20                  25                  30          


Gly Ser Leu Pro Val Asn Ala Gly Arg Leu Arg Pro Val Ser Ser Arg 
        35                  40                  45              


Pro Gln Glu Thr Val Gln Ala Gln Ser Ser Arg Leu Leu Leu Leu His 
    50                  55                  60                  


Pro Thr Ala Pro Ser Glu Ala Leu Gly Leu Pro Asp Leu Asp Leu Cys 
65                  70                  75                  80  


Leu Pro Ala Ser Ser Thr Pro Ser Ala Asp Ser Arg Pro Ser Cys Ile 
                85                  90                  95      


Gly Ala Ala Pro Leu Arg Pro Val Ser Thr Ser Ser Ser Trp Ile Gly 
            100                 105                 110         


Asn Gln Arg Arg Val Thr Val Thr Glu Val Leu Arg Glu Thr Ala Arg 
        115                 120                 125             


Pro Gln Ser Ser Ala Leu His Pro Leu Leu Thr Phe Glu Ser Gln Gln 
    130                 135                 140                 


Gln Gln Val Gly Gly Phe Glu Gly Pro Glu Gln Asp Glu Phe Asp Lys 
145                 150                 155                 160 


Val Leu Ala Ser Met Glu Leu Glu Glu Pro Gly Met Glu Leu Glu Cys 
                165                 170                 175     


Gly Val Ser Ser Glu Ala Ile Pro Ile Leu Pro Ala Gln Gln Arg Glu 
            180                 185                 190         


Gly Ser Val Leu Ala Lys Lys Ala Arg Val Val Asp Leu Ser Gly Ser 
        195                 200                 205             


Cys Gln Lys Gly Pro Val Pro Ala Ile His Lys Ala Gly Ile Met Ser 
    210                 215                 220                 


Ala Gln Asp Glu Ser Leu Asp Pro Val Ile Gln Cys Arg Thr Pro Arg 
225                 230                 235                 240 


Pro Pro Leu Arg Pro Gly Ala Val Gly His Leu Pro Val Pro Thr Ala 
                245                 250                 255     


Leu Thr Val Pro Thr Gln Gln Leu His Trp Glu Val Cys Pro Gln Arg 
            260                 265                 270         


Ser Pro Val Gln Ala Leu Gln Pro Leu Gln Ala Ala Arg Gly Thr Ile 
        275                 280                 285             


Gln Ser Ser Pro Gln Asn Arg Phe Pro Cys Gln Pro Phe Gln Ser Pro 
    290                 295                 300                 


Ser Ser Trp Leu Ser Gly Lys Ala His Leu Pro Arg Pro Arg Thr Pro 
305                 310                 315                 320 


Asn Ser Ser Cys Ser Thr Pro Ser Arg Thr Ser Ser Gly Leu Phe Pro 
                325                 330                 335     


Arg Ile Pro Leu Gln Pro Gln Ala Pro Val Ser Ser Ile Gly Ser Pro 
            340                 345                 350         


Val Gly Thr Pro Lys Gly Pro Gln Gly Ala Leu Gln Thr Pro Ile Val 
        355                 360                 365             


Thr Asn His Leu Val Gln Leu Val Thr Ala Ala Ser Arg Thr Pro Gln 
    370                 375                 380                 


Gln Pro Thr His Pro Ser Thr Arg Ala Lys Thr Arg Arg Phe Pro Gly 
385                 390                 395                 400 


Pro Ala Gly Ile Leu Pro His Gln Gln Ser Gly Arg Ser Leu Glu Asp 
                405                 410                 415     


Ile Met Val Ser Ala Pro Gln Thr Pro Thr His Gly Ala Leu Ala Lys 
            420                 425                 430         


Phe Gln Thr Glu Ile Val Ala Ser Ser Gln Ala Ser Val Glu Glu Asp 
        435                 440                 445             


Phe Gly Arg Gly Pro Trp Leu Thr Met Lys Ser Thr Leu Gly Leu Asp 
    450                 455                 460                 


Glu Arg Asp Pro Ser Cys Phe Leu Cys Thr Tyr Ser Ile Val Met Val 
465                 470                 475                 480 


Leu Arg Lys Gln Ala Ala Leu Lys Gln Leu Pro Arg Asn Lys Val Pro 
                485                 490                 495     


Asn Met Ala Val Met Ile Lys Ser Leu Thr Arg Ser Thr Met Asp Ala 
            500                 505                 510         


Ser Val Val Phe Lys Asp Pro Thr Gly Glu Met Gln Gly Thr Val His 
        515                 520                 525             


Arg Leu Leu Leu Glu Thr Cys Gln Asn Glu Leu Lys Pro Gly Ser Val 
    530                 535                 540                 


Leu Leu Leu Lys Gln Ile Gly Val Phe Ser Pro Ser Leu Arg Asn His 
545                 550                 555                 560 


Tyr Leu Asn Val Thr Pro Asn Asn Leu Val His Ile Tyr Ser Pro Asp 
                565                 570                 575     


Ser Gly Asp Gly Ser Phe Leu Lys Pro Ser Gln Pro Phe Pro Lys Asp 
            580                 585                 590         


Ser Gly Ser Phe Gln His Asp Val Ala Ala Lys Pro Glu Glu Gly Phe 
        595                 600                 605             


Arg Thr Ala Gln Asn Leu Glu Ala Glu Ala Ser Pro Glu Glu Glu Leu 
    610                 615                 620                 


Pro Glu Ala Asp Asp Leu Asp Gly Leu Leu Ser Glu Leu Pro Glu Asp 
625                 630                 635                 640 


Phe Phe Cys Gly Thr Ser Ser 
                645         


<210>  1340
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C17orf64__Homo_sapiens__NP_859058

<400>  1340

Met Glu Ala Ser Asp Gly Gln Gly Gly Glu Gly Asp Lys Pro Leu Glu 
1               5                   10                  15      


Gln Val Thr Asn Val Ser Cys Leu Glu Thr Ser Ser Ser Ala Ser Pro 
            20                  25                  30          


Ala Arg Asp Ser Leu Met Arg His Ala Lys Gly Leu Asp Gln Asp Thr 
        35                  40                  45              


Phe Lys Thr Cys Lys Glu Tyr Leu Arg Pro Leu Lys Lys Phe Leu Arg 
    50                  55                  60                  


Lys Leu His Leu Pro Arg Asp Leu Pro Gln Lys Lys Lys Leu Lys Tyr 
65                  70                  75                  80  


Met Lys Gln Ser Leu Val Val Leu Gly Asp His Ile Asn Thr Phe Leu 
                85                  90                  95      


Gln His Tyr Cys Gln Ala Trp Glu Ile Lys His Trp Arg Lys Met Leu 
            100                 105                 110         


Trp Arg Phe Ile Ser Leu Phe Ser Glu Leu Glu Ala Lys Gln Leu Arg 
        115                 120                 125             


Arg Leu Tyr Lys Tyr Thr Lys Ser Ser Gln Pro Ala Lys Phe Leu Val 
    130                 135                 140                 


Thr Phe Cys Ala Ser Asp Ala Pro Glu Arg Ser Leu Leu Ala Asp Arg 
145                 150                 155                 160 


Glu Asp Ser Leu Pro Lys Leu Cys His Ala Trp Gly Leu His Ser Asn 
                165                 170                 175     


Ile Ser Gly Met Lys Glu Arg Leu Ser Asn Met Gln Thr Pro Gly Gln 
            180                 185                 190         


Gly Ser Pro Leu Pro Gly Gln Pro Arg Ser Gln Asp His Val Lys Lys 
        195                 200                 205             


Asp Ser Leu Arg Glu Leu Ser Gln Lys Pro Lys Leu Lys Arg Lys Arg 
    210                 215                 220                 


Ile Lys Glu Ala Pro Glu Thr Pro Glu Thr Glu Pro 
225                 230                 235     


<210>  1341
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C17orf96__Homo_sapiens__NP_001124149

<400>  1341

Met Glu Thr Leu Cys Pro Ala Pro Arg Leu Ala Val Pro Ala Ser Pro 
1               5                   10                  15      


Arg Gly Ser Pro Cys Ser Pro Thr Pro Arg Lys Pro Cys Arg Gly Thr 
            20                  25                  30          


Gln Glu Phe Ser Pro Leu Cys Leu Arg Ala Leu Ala Phe Cys Ala Leu 
        35                  40                  45              


Ala Lys Pro Arg Ala Ser Ser Leu Gly Pro Gly Pro Gly Glu Leu Ala 
    50                  55                  60                  


Ala Arg Ser Pro Val Leu Arg Gly Pro Gln Ala Pro Leu Arg Pro Gly 
65                  70                  75                  80  


Gly Trp Ala Pro Asp Gly Leu Lys His Leu Trp Ala Pro Thr Gly Arg 
                85                  90                  95      


Pro Gly Val Pro Asn Thr Ala Ala Gly Glu Asp Ala Asp Val Ala Ala 
            100                 105                 110         


Cys Pro Arg Arg Gly Glu Glu Glu Glu Gly Gly Gly Gly Phe Pro His 
        115                 120                 125             


Phe Gly Val Arg Ser Cys Ala Pro Pro Gly Arg Cys Pro Ala Pro Pro 
    130                 135                 140                 


His Pro Arg Glu Ser Thr Thr Ser Phe Ala Ser Ala Pro Pro Arg Pro 
145                 150                 155                 160 


Ala Pro Gly Leu Glu Pro Gln Arg Gly Pro Ala Ala Ser Pro Pro Gln 
                165                 170                 175     


Glu Pro Ser Ser Arg Pro Pro Ser Pro Pro Ala Gly Leu Ser Thr Glu 
            180                 185                 190         


Pro Ala Gly Pro Gly Thr Ala Pro Arg Pro Phe Leu Pro Gly Gln Pro 
        195                 200                 205             


Ala Glu Val Asp Gly Asn Pro Pro Pro Ala Ala Pro Glu Ala Pro Ala 
    210                 215                 220                 


Ala Ser Pro Ser Thr Ala Ser Pro Ala Pro Ala Ala Pro Gly Asp Leu 
225                 230                 235                 240 


Arg Gln Glu His Phe Asp Arg Leu Ile Arg Arg Ser Lys Leu Trp Cys 
                245                 250                 255     


Tyr Ala Lys Gly Phe Ala Leu Asp Thr Pro Ser Leu Arg Arg Gly Pro 
            260                 265                 270         


Glu Arg Pro Pro Ala Lys Gly Pro Ala Arg Gly Ala Ala Lys Lys Arg 
        275                 280                 285             


Arg Leu Pro Ala Pro Pro Pro Arg Thr Ala Gln Pro Arg Arg Pro Ala 
    290                 295                 300                 


Pro Thr Leu Pro Thr Thr Ser Thr Phe Ser Leu Leu Asn Cys Phe Pro 
305                 310                 315                 320 


Cys Pro Pro Ala Leu Val Val Gly Glu Asp Gly Asp Leu Lys Pro Ala 
                325                 330                 335     


Ser Ser Leu Arg Leu Gln Gly Asp Ser Lys Pro Pro Pro Ala His Pro 
            340                 345                 350         


Leu Trp Arg Trp Gln Met Gly Gly Pro Ala Val Pro Glu Pro Pro Gly 
        355                 360                 365             


Leu Lys Phe Trp Gly Ile Asn Met Asp Glu Ser 
    370                 375                 


<210>  1342
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C18orf54__Homo_sapiens__NP_001275909

<400>  1342

Met Ala Lys Ser Lys Thr Lys His Arg Leu Cys Ser Gln Glu Ser Ser 
1               5                   10                  15      


Val Ser Ala Leu Leu Ala Ser Cys Thr Leu Ser Gly Ser Asn Ser Ser 
            20                  25                  30          


Asn Ser Asp Gly Ser Phe His Tyr Lys Asp Lys Leu Tyr Arg Ser Ala 
        35                  40                  45              


Ser Gln Ala Leu Gln Ala Tyr Ile Asp Asp Phe Asp Leu Gly Gln Ile 
    50                  55                  60                  


Tyr Pro Gly Ala Ser Thr Gly Lys Ile Asn Ile Asp Glu Asp Phe Thr 
65                  70                  75                  80  


Asn Met Ser Gln Phe Cys Asn Tyr Ile Tyr Lys Pro Asn Asn Ala Phe 
                85                  90                  95      


Glu Asn Leu Asp His Lys Lys His Ser Asn Phe Ile Ser Cys Arg Arg 
            100                 105                 110         


His Thr Val Asn Asp Ile Asp Ser Met Ser Leu Thr Thr Asp Asp Leu 
        115                 120                 125             


Leu Arg Leu Pro Ala Asp Gly Ser Phe Ser Tyr Thr Tyr Val Gly Pro 
    130                 135                 140                 


Ser His Arg Thr Ser Lys Lys Asn Lys Lys Cys Arg Gly Arg Leu Gly 
145                 150                 155                 160 


Ser Leu Asp Ile Glu Lys Asn Pro His Phe Gln Gly Pro Tyr Thr Ser 
                165                 170                 175     


Met Gly Lys Asp Asn Phe Val Thr Pro Val Ile Arg Ser Asn Ile Asn 
            180                 185                 190         


Gly Lys Gln Cys Gly Arg Leu Lys Asn Pro Lys Leu Met Asn Arg Thr 
        195                 200                 205             


Asn Asn Cys Ile Ser Glu Ser Ser Leu Ser Phe Pro Lys Lys Ser Ser 
    210                 215                 220                 


Phe Lys Asp Ser Ser Glu His Ser Leu Glu Lys Asn Tyr Pro Arg Trp 
225                 230                 235                 240 


Leu Thr Ser Gln Lys Ser Asp Leu Asn Val Ser Gly Ile Thr Ser Ile 
                245                 250                 255     


Pro Asp Phe Lys Tyr Pro Val Trp Leu His Asn Gln Asp Leu Leu Pro 
            260                 265                 270         


Asp Ala Asn Ser Gln Arg Val Tyr Gln Ile Phe Lys Asp Asp Gln Cys 
        275                 280                 285             


Ser Pro Arg His Ser His Gln Ala Gln Gly Thr Ser Arg Leu Ile Asn 
    290                 295                 300                 


Lys Leu Asp Cys Phe Glu Tyr Ala Phe Glu Pro Ser Asn Phe Ser Asn 
305                 310                 315                 320 


Ser Leu Ser Asp Asp Lys Glu Leu Val Asn Glu Tyr Lys Cys Asp Phe 
                325                 330                 335     


Glu His Ser Gln Cys Gln Cys Glu Asn Pro Leu Leu Pro Gly Gln Ser 
            340                 345                 350         


Thr Lys Pro Phe Ser Gly Asp Lys Ile Glu Leu Leu Ile Leu Lys Ala 
        355                 360                 365             


Lys Arg Asn Leu Glu Gln Cys Thr Glu Glu Leu Pro Lys Ser Met Lys 
    370                 375                 380                 


Lys Asp Asp Ser Pro Cys Ser Leu Asp Lys Leu Glu Ala Asp Arg Ser 
385                 390                 395                 400 


Trp Glu Asn Ile Pro Val Thr Phe Lys Ser Pro Val Pro Val Asn Ser 
                405                 410                 415     


Asp Asp Ser Pro Gln Gln Thr Ser Arg Ala Lys Ser Ala Lys Gly Val 
            420                 425                 430         


Leu Glu Asp Phe Leu Asn Asn Asp Asn Gln Ser Cys Thr Leu Ser Gly 
        435                 440                 445             


Gly Lys His His Gly Pro Val Glu Ala Leu Lys Gln Met Leu Phe Asn 
    450                 455                 460                 


Leu Gln Ala Val Gln Glu Arg Phe Asn Gln Asn Lys Thr Thr Asp Pro 
465                 470                 475                 480 


Lys Glu Glu Ile Lys Gln Val Ser Glu Asp Asp Phe Ser Lys Leu Gln 
                485                 490                 495     


Leu Lys Glu Ser Met Ile Pro Ile Thr Arg Ser Leu Gln Lys Ala Leu 
            500                 505                 510         


His His Leu Ser Arg Leu Arg Asp Leu Val Asp Asp Thr Asn Gly Glu 
        515                 520                 525             


Arg Ser Pro Lys Met 
    530             


<210>  1343
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C18orf8__Homo_sapiens__NP_001263271

<400>  1343

Met Gly Glu Glu Asp Tyr Tyr Leu Glu Leu Cys Glu Arg Pro Val Gln 
1               5                   10                  15      


Phe Glu Lys Ala Asn Pro Val Asn Cys Val Phe Phe Asp Glu Ala Asn 
            20                  25                  30          


Lys Gln Val Phe Ala Val Arg Ser Gly Gly Ala Thr Gly Val Val Val 
        35                  40                  45              


Lys Gly Pro Asp Asp Arg Asn Pro Ile Ser Phe Arg Met Asp Asp Lys 
    50                  55                  60                  


Gly Glu Val Lys Cys Ile Lys Phe Ser Leu Glu Asn Lys Ile Leu Ala 
65                  70                  75                  80  


Val Gln Arg Thr Ser Lys Thr Val Val Leu Pro Glu Lys Arg Ser Leu 
                85                  90                  95      


Lys Leu Leu Lys Ser His Asn Leu Asn Val Asn Trp Tyr Met Tyr Cys 
            100                 105                 110         


Pro Glu Ser Ala Val Ile Leu Leu Ser Thr Thr Val Leu Glu Asn Val 
        115                 120                 125             


Leu Gln Pro Phe His Phe Arg Ala Gly Thr Met Ser Lys Leu Pro Lys 
    130                 135                 140                 


Phe Glu Ile Glu Leu Pro Ala Ala Pro Lys Ser Thr Lys Pro Ser Leu 
145                 150                 155                 160 


Ser Glu Arg Asp Ile Ala Met Ala Thr Ile Tyr Gly Gln Leu Tyr Val 
                165                 170                 175     


Leu Phe Leu Arg His His Ser Arg Thr Ser Asn Ser Thr Gly Ala Glu 
            180                 185                 190         


Val Val Leu Tyr His Leu Pro Arg Glu Gly Ala Cys Lys Lys Met His 
        195                 200                 205             


Ile Leu Lys Leu Asn Arg Thr Gly Lys Phe Ala Leu Asn Val Val Asp 
    210                 215                 220                 


Asn Leu Val Val Val His His Gln Asp Thr Glu Thr Ser Val Ile Phe 
225                 230                 235                 240 


Asp Ile Lys Leu Arg Gly Glu Phe Asp Gly Ser Val Thr Phe His His 
                245                 250                 255     


Pro Val Leu Pro Ala Arg Ser Ile Gln Pro Tyr Gln Ile Pro Ile Thr 
            260                 265                 270         


Gly Pro Ala Ala Val Thr Ser Gln Ser Pro Val Pro Cys Lys Leu Tyr 
        275                 280                 285             


Ser Ser Ser Trp Ile Val Phe Gln Pro Asp Ile Ile Ile Ser Ala Ser 
    290                 295                 300                 


Gln Gly Tyr Leu Trp Asn Leu Gln Val Lys Leu Glu Pro Ile Val Asn 
305                 310                 315                 320 


Leu Leu Pro Asp Lys Gly Arg Leu Met Asp Phe Leu Leu Gln Arg Lys 
                325                 330                 335     


Glu Cys Lys Met Val Ile Leu Ser Val Cys Ser Gln Met Leu Ser Glu 
            340                 345                 350         


Ser Asp Arg Ala Ser Leu Pro Val Ile Ala Thr Val Phe Asp Lys Leu 
        355                 360                 365             


Asn His Glu Tyr Lys Lys Tyr Leu Asp Ala Glu Gln Ser Tyr Ala Met 
    370                 375                 380                 


Ala Val Glu Ala Gly Gln Ser Arg Ser Ser Pro Leu Leu Lys Arg Pro 
385                 390                 395                 400 


Val Arg Thr Gln Ala Val Leu Asp Gln Ser Asp Val Tyr Thr His Val 
                405                 410                 415     


Leu Ser Ala Phe Val Glu Lys Lys Glu Met Pro His Lys Phe Val Ile 
            420                 425                 430         


Ala Val Leu Met Glu Tyr Ile Arg Ser Leu Asn Gln Phe Gln Ile Ala 
        435                 440                 445             


Val Gln His Tyr Leu His Glu Leu Val Ile Lys Thr Leu Val Gln His 
    450                 455                 460                 


Asn Leu Phe Tyr Met Leu His Gln Phe Leu Gln Tyr His Val Leu Ser 
465                 470                 475                 480 


Asp Ser Lys Pro Leu Ala Cys Leu Leu Leu Ser Leu Glu Ser Phe Tyr 
                485                 490                 495     


Pro Pro Ala His Gln Leu Ser Leu Asp Met Leu Lys Met Leu Gln Ser 
            500                 505                 510         


Arg Leu Lys Thr Thr Cys Phe Ser Ile Gln Tyr Ser Ala Phe Leu Asn 
        515                 520                 525             


Ser Glu Thr Ser Val Cys Glu Gly Ala Pro Ile Ser His Gln Gly Asn 
    530                 535                 540                 


Thr Val Lys Asn Met Leu Leu Phe Ser Asn Arg Phe Leu Glu Thr Lys 
545                 550                 555                 560 


Leu 
    


<210>  1344
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf12__Homo_sapiens__NP_001026896

<400>  1344

Met Glu Arg Leu Lys Ser His Lys Pro Ala Thr Met Thr Ile Met Val 
1               5                   10                  15      


Glu Asp Ile Met Lys Leu Leu Cys Ser Leu Ser Gly Glu Arg Lys Met 
            20                  25                  30          


Lys Ala Ala Val Lys His Ser Gly Lys Gly Ala Leu Val Thr Gly Ala 
        35                  40                  45              


Met Ala Phe Val Gly Gly Leu Val Gly Gly Pro Pro Gly Leu Ala Val 
    50                  55                  60                  


Gly Gly Ala Val Gly Gly Leu Leu Gly Ala Trp Met Thr Ser Gly Gln 
65                  70                  75                  80  


Phe Lys Pro Val Pro Gln Ile Leu Met Glu Leu Pro Pro Ala Glu Gln 
                85                  90                  95      


Gln Arg Leu Phe Asn Glu Ala Ala Ala Ile Ile Arg His Leu Glu Trp 
            100                 105                 110         


Thr Asp Ala Val Gln Leu Thr Ala Leu Val Met Gly Ser Glu Ala Leu 
        115                 120                 125             


Gln Gln Gln Leu Leu Ala Met Leu Val Asn Tyr Val Thr Lys Glu Leu 
    130                 135                 140                 


Arg Ala Glu Ile Gln Tyr Asp Asp 
145                 150         


<210>  1345
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf18__Homo_sapiens__NP_689687

<400>  1345

Met Asp Lys Val Gln Ser Gly Phe Leu Ile Leu Phe Leu Phe Leu Met 
1               5                   10                  15      


Glu Cys Gln Leu His Leu Cys Leu Pro Tyr Ala Asp Gly Leu His Pro 
            20                  25                  30          


Thr Gly Asn Ile Thr Gly Leu Pro Gly Ser Lys Arg Ser Gln Pro Pro 
        35                  40                  45              


Arg Asn Ile Thr Lys Glu Pro Lys Val Phe Phe His Lys Thr Gln Leu 
    50                  55                  60                  


Pro Gly Ile Gln Gly Ala Ala Ser Arg Ser Thr Ala Ala Ser Pro Thr 
65                  70                  75                  80  


Asn Pro Met Lys Phe Leu Arg Asn Lys Ala Ile Ile Arg His Arg Pro 
                85                  90                  95      


Ala Leu Val Lys Val Ile Leu Ile Ser Ser Val Ala Phe Ser Ile Ala 
            100                 105                 110         


Leu Ile Cys Gly Met Ala Ile Ser Tyr Met Ile Tyr Arg Leu Ala Gln 
        115                 120                 125             


Ala Glu Glu Arg Gln Gln Leu Glu Ser Leu Tyr Lys Asn Leu Arg Ile 
    130                 135                 140                 


Pro Leu Leu Gly Asp Glu Glu Glu Gly Ser Glu Asp Glu Gly Glu Ser 
145                 150                 155                 160 


Thr His Leu Leu Pro Glu Asn Glu Asn Glu Leu Glu Lys Phe Ile His 
                165                 170                 175     


Ser Val Ile Ile Ser Lys Arg Ser Lys Asn Ile Lys Lys Lys Leu Lys 
            180                 185                 190         


Glu Glu Gln Asn Ser Val Thr Glu Asn Lys Thr Lys Asn Ala Ser His 
        195                 200                 205             


Asn Gly Lys Met Glu Asp Leu 
    210                 215 


<210>  1346
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf24__Homo_sapiens__NP_060384

<400>  1346

Met Gly Pro Arg Val Leu Gln Pro Pro Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ala Ala Leu Pro Cys Gly Ala Glu Glu Ala Ser Pro Leu 
            20                  25                  30          


Arg Pro Ala Gln Val Thr Leu Ser Pro Pro Pro Ala Val Thr Asn Gly 
        35                  40                  45              


Ser Gln Pro Gly Ala Pro His Asn Ser Thr His Thr Arg Pro Pro Gly 
    50                  55                  60                  


Ala Ser Gly Ser Ala Leu Thr Arg Ser Phe Tyr Val Ile Leu Gly Phe 
65                  70                  75                  80  


Cys Gly Leu Thr Ala Leu Tyr Phe Leu Ile Arg Ala Phe Arg Leu Lys 
                85                  90                  95      


Lys Pro Gln Arg Arg Arg Tyr Gly Leu Leu Ala Asn Thr Glu Asp Pro 
            100                 105                 110         


Thr Glu Met Ala Ser Leu Asp Ser Asp Glu Glu Thr Val Phe Glu Ser 
        115                 120                 125             


Arg Asn Leu Arg 
    130         


<210>  1347
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf26__Homo_sapiens__NP_689982

<400>  1347

Met Gln Pro Thr Ala Thr Met Ala Thr Ala Ala Thr Thr Thr Thr Thr 
1               5                   10                  15      


Thr Thr Ala Thr Val Ala Leu Thr Thr Ser Trp Asp Asn Ala Thr Gly 
            20                  25                  30          


Arg Pro Thr Ala Glu Pro Asp Pro Ile Leu Asp Asn Tyr Val Leu Leu 
        35                  40                  45              


Val Val Val Met Ser Leu Phe Val Gly Gly Thr Leu Val Val Leu Ser 
    50                  55                  60                  


Gly Val Leu Leu Leu Cys Lys Arg Cys Trp Asp Val His Gln Arg Leu 
65                  70                  75                  80  


Asn Arg Ala Met Glu Glu Ala Glu Lys Thr Thr Thr Thr Tyr Leu Asp 
                85                  90                  95      


Asn Gly Thr His Pro Ala Gln Asp Pro Asp Phe Arg Gly Glu Asp Pro 
            100                 105                 110         


Glu Cys Gln Asp Ala Glu Thr Glu Arg Phe Leu Ser Thr Ser Ser Thr 
        115                 120                 125             


Gly Arg Arg Val Ser Phe Asn Glu Ala Ala Leu Phe Glu Gln Ser Arg 
    130                 135                 140                 


Lys Thr Gln Asp Lys Gly Arg Arg Tyr Thr Leu Thr Glu Gly Asp Phe 
145                 150                 155                 160 


His His Leu Lys Asn Ala Arg Leu Thr His Leu His Leu Pro Pro Leu 
                165                 170                 175     


Lys Ile Val Thr Ile His Glu Cys Asp Ser Gly Glu Ala Ser Ser Ala 
            180                 185                 190         


Thr Thr Pro His Pro Ala Thr Ser Pro Lys Ala Thr Leu Ala Ile Phe 
        195                 200                 205             


Gln Pro Pro Gly Lys Ala Leu Thr Gly Arg Ser Val Gly Pro Ser Ser 
    210                 215                 220                 


Ala Leu Pro Gly Asp Pro Tyr Asn Ser Ala Ala Gly Ala Thr Asp Phe 
225                 230                 235                 240 


Ala Glu Ile Ser Pro Ser Ala Ser Ser Asp Ser Gly Glu Gly Thr Ser 
                245                 250                 255     


Leu Asp Ala Gly Thr Arg Ser Thr Lys Ala Gly Gly Pro Gly Ala Ala 
            260                 265                 270         


Ala Gly Pro Gly Glu Ala Gly Pro Gly Ser Gly Ala Gly Thr Val Leu 
        275                 280                 285             


Gln Phe Leu Thr Arg Leu Arg Arg His Ala Ser Leu Asp Gly Ala Ser 
    290                 295                 300                 


Pro Tyr Phe Lys Val Lys Lys Trp Lys Leu Glu Pro Ser Gln Arg Ala 
305                 310                 315                 320 


Ala Ser Leu Asp Thr Arg Gly Ser Pro Lys Arg His His Phe Gln Arg 
                325                 330                 335     


Gln Arg Ala Ala Ser Glu Ser Thr Glu Gln Glu Glu Gly Asp Ala Pro 
            340                 345                 350         


Gln Glu Asp Phe Ile Gln Tyr Ile Ala Arg Ala Gly Asp Ala Val Ala 
        355                 360                 365             


Phe Pro His Pro Arg Pro Phe Leu Ala Ser Pro Pro Pro Ala Leu Gly 
    370                 375                 380                 


Arg Tyr Phe Ser Val Asp Gly Gly Ala Arg Gly Gly Pro Val Gly Pro 
385                 390                 395                 400 


Cys Pro Pro Ser Pro Pro Pro Arg Arg Pro Arg Glu Arg Ser Pro Gly 
                405                 410                 415     


Pro Val Asp Thr Arg Ser Pro Ala Ser Ser Gly Lys Ala Pro Pro Arg 
            420                 425                 430         


Gly Gly Leu Thr Gly Ala Thr Ser Pro Ala Trp Thr Arg Gly Gly Lys 
        435                 440                 445             


Gln Gly Glu Thr Gly 
    450             


<210>  1348
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf33__Homo_sapiens__NP_277055

<400>  1348

Met Glu Phe Asp Leu Gly Ala Ala Leu Glu Pro Thr Ser Gln Lys Pro 
1               5                   10                  15      


Gly Val Gly Ala Gly His Gly Gly Asp Pro Lys Leu Ser Pro His Lys 
            20                  25                  30          


Val Gln Gly Arg Ser Glu Ala Gly Ala Gly Pro Gly Pro Lys Gln Gly 
        35                  40                  45              


His His Ser Ser Ser Asp Ser Ser Ser Ser Ser Ser Asp Ser Asp Thr 
    50                  55                  60                  


Asp Val Lys Ser His Ala Ala Gly Ser Lys Gln His Glu Ser Ile Pro 
65                  70                  75                  80  


Gly Lys Ala Lys Lys Pro Lys Val Lys Lys Lys Glu Lys Gly Lys Lys 
                85                  90                  95      


Glu Lys Gly Lys Lys Lys Glu Ala Pro His 
            100                 105     


<210>  1349
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf40__Homo_sapiens__NP_689479

<400>  1349

Met Glu Lys Asn Pro Pro Asp Asp Thr Gly Pro Val His Val Pro Leu 
1               5                   10                  15      


Gly His Ile Val Ala Asn Glu Lys Trp Arg Gly Ser Gln Leu Ala Gln 
            20                  25                  30          


Glu Met Gln Gly Lys Ile Lys Leu Ile Phe Glu Asp Gly Leu Thr Pro 
        35                  40                  45              


Asp Phe Tyr Leu Ser Asn Arg Cys Cys Ile Leu Tyr Val Thr Glu Ala 
    50                  55                  60                  


Asp Leu Val Ala Gly Asn Gly Tyr Arg Lys Arg Leu Val Arg Val Arg 
65                  70                  75                  80  


Asn Ser Asn Asn Leu Lys Gly Ile Val Val Val Glu Lys Thr Arg Met 
                85                  90                  95      


Ser Glu Gln Tyr Phe Pro Ala Leu Gln Lys Phe Thr Val Leu Asp Leu 
            100                 105                 110         


Gly Met Val Leu Leu Pro Val Ala Ser Gln Met Glu Ala Ser Cys Leu 
        115                 120                 125             


Val Ile Gln Leu Val Gln Glu Gln Thr Lys Glu Pro Ser Lys Asn Pro 
    130                 135                 140                 


Leu Leu Gly Lys Lys Arg Ala Leu Leu Leu Ser Glu Pro Ser Leu Leu 
145                 150                 155                 160 


Arg Thr Val Gln Gln Ile Pro Gly Val Gly Lys Val Lys Ala Pro Leu 
                165                 170                 175     


Leu Leu Gln Lys Phe Pro Ser Ile Gln Gln Leu Ser Asn Ala Ser Ile 
            180                 185                 190         


Gly Glu Leu Glu Gln Val Val Gly Gln Ala Val Ala Gln Gln Ile His 
        195                 200                 205             


Ala Phe Phe Thr Gln Pro Arg 
    210                 215 


<210>  1350
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf45__Homo_sapiens__XP_011526294

<400>  1350

Met Ala Thr Gly Ala Leu Leu Pro Cys Ser Arg Pro Cys Pro Met Ser 
1               5                   10                  15      


Arg Leu Asp Phe Leu Lys Ala Ser His Phe Ser Leu Gly Pro Asp Leu 
            20                  25                  30          


Arg Leu His Glu Gly Thr Met Arg Thr Thr Ser His Arg Asp Phe Ala 
        35                  40                  45              


Tyr Pro Ala Ala Thr Arg Glu Pro Pro Ser Leu Gln Pro Pro Pro Ala 
    50                  55                  60                  


Leu Leu Phe Pro Met Asp Pro Arg Trp Asp Arg Glu Glu Arg Val Ser 
65                  70                  75                  80  


Glu Ala His Arg Ala Phe Pro Pro Pro Ser Thr Pro Pro Trp Glu Leu 
                85                  90                  95      


Leu Gln Ala Gln Ala Arg Glu Arg Thr Leu Ala Met Gln Ala Gly Asn 
            100                 105                 110         


Leu His Leu His Glu Asp Ala His Ala Gly Ile Gly Leu Ser Asn Ala 
        115                 120                 125             


His Ala Ala Tyr Gly Trp Pro Glu Leu Pro Ala Arg Thr Arg Glu Arg 
    130                 135                 140                 


Ile Arg Gly Ala Arg Leu Ile Phe Asp Arg Asp Ser Leu Pro Pro Gly 
145                 150                 155                 160 


Asp Arg Asp Lys Leu Arg Ile Pro Pro Thr Thr His Gln Ala Leu Phe 
                165                 170                 175     


Pro Pro His Asp Ala Arg Pro Gln Pro Arg Ala Pro Ser Cys His Leu 
            180                 185                 190         


Gly Gly Pro Asn Thr Leu Lys Trp Asp Tyr Thr Arg Gln Asp Gly Thr 
        195                 200                 205             


Ser Tyr Gln Arg Gln Phe Gln Ala Leu Pro Gly Pro Pro Ala Leu Arg 
    210                 215                 220                 


Cys Lys Arg Ala Ser Ser Gly Val Glu Leu Gly Asp Cys Lys Ile Ser 
225                 230                 235                 240 


Tyr Gly Ser Thr Cys Ser Glu Gln Lys Gln Ala Tyr Arg Pro Gln Asp 
                245                 250                 255     


Leu Pro Glu Asp Arg Tyr Asp Lys Ala Gln Ala Thr Ala His Ile His 
            260                 265                 270         


Cys Val Asn Ile Arg Pro Gly Asp Gly Leu Phe Arg Asp Arg Thr Thr 
        275                 280                 285             


Lys Ala Glu His Phe Tyr Ala Arg Glu Pro Glu Pro Phe Val Leu His 
    290                 295                 300                 


His Asp Gln Thr Pro Glu Ser His Ile Leu Lys Gly Asn Trp Cys Pro 
305                 310                 315                 320 


Gly Pro Gly Ser Leu Asp Thr Phe Met Gln Tyr Phe Tyr Gly Gln Pro 
                325                 330                 335     


Pro Pro Pro Thr Gln Pro Pro Ser Arg His Val Pro His Glu Lys Leu 
            340                 345                 350         


Gln Ser His Val Thr Leu Gly Glu Pro Lys Leu Leu Lys Arg Phe Phe 
        355                 360                 365             


Lys Thr Thr Met Gly Ser Asp Tyr Cys Pro Ser Glu Trp Arg Gln Val 
    370                 375                 380                 


Gln Lys Ala Pro Asn Leu His Leu Gln Gln Ser Tyr Leu Pro Arg Gly 
385                 390                 395                 400 


Thr Gly Glu Phe Asp Phe Leu Thr Met Asn Gln Lys Met Leu Lys Pro 
                405                 410                 415     


His Arg Thr Pro Pro Ala Pro Val Thr Glu Glu Met Leu Gln Arg Cys 
            420                 425                 430         


Lys Tyr Ser His Met Glu Pro Pro Leu Gly Gly Leu Arg Phe Phe Ser 
        435                 440                 445             


Thr Gln Tyr Lys Asp Glu Phe Pro Phe Lys Tyr Gln Gly Pro Ala Ala 
    450                 455                 460                 


Leu Arg Leu Lys Asn Pro Gln Glu Gly Phe Val Pro Leu Gly Thr Pro 
465                 470                 475                 480 


His Gln Arg Gly Cys Arg Glu Lys Ile Asp Pro Leu Val Pro Gln Pro 
                485                 490                 495     


Pro Met Tyr Leu Cys Pro Ser Gln Gln 
            500                 505 


<210>  1351
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf48__Homo_sapiens__NP_001277083

<400>  1351

Met Thr Val Leu Glu Ala Val Leu Glu Ile Gln Ala Ile Thr Gly Ser 
1               5                   10                  15      


Arg Leu Leu Ser Met Val Pro Gly Pro Ala Arg Pro Pro Gly Ser Cys 
            20                  25                  30          


Trp Asp Pro Thr Gln Cys Thr Arg Thr Trp Leu Leu Ser His Thr Pro 
        35                  40                  45              


Arg Arg Arg Trp Ile Ser Gly Leu Pro Arg Ala Ser Cys Arg Leu Gly 
    50                  55                  60                  


Glu Glu Pro Pro Pro Leu Pro Tyr Cys Asp Gln Ala Tyr Gly Glu Glu 
65                  70                  75                  80  


Leu Ser Ile Arg His Arg Glu Thr Trp Ala Trp Leu Ser Arg Thr Asp 
                85                  90                  95      


Thr Ala Trp Pro Gly Ala Pro Gly Val Lys Gln Ala Arg Ile Leu Gly 
            100                 105                 110         


Glu Leu Leu Leu Val 
        115         


<210>  1352
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf57__Homo_sapiens__NP_077299

<400>  1352

Met Thr Lys Arg Lys Lys Leu Arg Thr Ser Gly Glu Gly Leu Cys Pro 
1               5                   10                  15      


Pro Lys Pro Leu Lys Asn Pro Arg Leu Gly Asp Phe Tyr Gly Asp Pro 
            20                  25                  30          


Gln Ser Ser Met Leu Gly Cys Leu His His Pro Glu Glu Pro Glu Gly 
        35                  40                  45              


Lys Leu Gly Pro Val Pro Ser Thr Gln Gln His Gly Glu Glu Pro Gly 
    50                  55                  60                  


Lys Ala Val Ser Ser Ser Pro Asp Glu Glu Thr Gly Ser Pro Cys Arg 
65                  70                  75                  80  


Leu Leu Arg Gln Pro Glu Lys Glu Pro Ala Pro Leu Pro Pro Ser Gln 
                85                  90                  95      


Asn Ser Phe Gly Arg Phe Val Pro Gln Phe Ala Lys Ser Arg Lys Thr 
            100                 105                 110         


Val Thr Arg Lys Glu Glu Met Lys Asp Glu Asp Arg Gly Ser Gly Ala 
        115                 120                 125             


Phe Ser Leu Glu Thr Ile Ala Glu Ser Ser Ala Gln Ser Pro Gly Cys 
    130                 135                 140                 


Gln Leu Leu Val Glu Thr Leu Gly Val Pro Leu Gln Glu Ala Thr Glu 
145                 150                 155                 160 


Leu Gly Asp Pro Thr Gln Ala Asp Ser Ala Arg Pro Glu Gln Ser Ser 
                165                 170                 175     


Gln Ser Pro Val Gln Ala Val Pro Gly Ser Gly Asp Ser Gln Pro Asp 
            180                 185                 190         


Asp Pro Pro Asp Arg Gly Thr Gly Leu Ser Ala Ser Gln Arg Ala Ser 
        195                 200                 205             


Gln Asp His Leu Ser Glu Gln Gly Ala Asp Asp Ser Lys Pro Glu Thr 
    210                 215                 220                 


Asp Arg Val Pro Gly Asp Gly Gly Gln Lys Glu His Leu Pro Ser Ile 
225                 230                 235                 240 


Asp Ser Glu Gly Glu Lys Pro Asp Arg Gly Ala Pro Gln Glu Gly Gly 
                245                 250                 255     


Ala Gln Arg Thr Ala Gly Ala Gly Leu Pro Gly Gly Pro Gln Glu Glu 
            260                 265                 270         


Gly Asp Gly Val Pro Cys Thr Pro Ala Ser Ala Pro Thr Ser Gly Pro 
        275                 280                 285             


Ala Pro Gly Leu Gly Pro Ala Ser Trp Cys Leu Glu Pro Gly Ser Val 
    290                 295                 300                 


Ala Gln Gly Ser Pro Asp Pro Gln Gln Thr Pro Ser Arg Met Gly Arg 
305                 310                 315                 320 


Glu Gly Glu Gly Thr His Ser Ser Leu Gly Cys Ser Ser Leu Gly Met 
                325                 330                 335     


Val Val Ile Ala Asp Leu Ser Thr Asp Pro Thr Glu Leu Glu Glu Arg 
            340                 345                 350         


Ala Leu Glu Val Ala Gly Pro Asp Gly Gln Ala Ser Ala Ile Ser Pro 
        355                 360                 365             


Ala Ser Pro Arg Arg Lys Ala Ala Asp Gly Gly His Arg Arg Ala Leu 
    370                 375                 380                 


Pro Gly Cys Thr Ser Leu Thr Gly Glu Thr Thr Gly Glu Ser Gly Glu 
385                 390                 395                 400 


Ala Gly Gln Asp Gly Lys Pro Pro Gly Asp Val Leu Val Gly Pro Thr 
                405                 410                 415     


Ala Ser Leu Ala Leu Ala Pro Gly Ser Gly Glu Ser Met Met Gly Ala 
            420                 425                 430         


Gly Asp Ser Gly His Ala Ser Pro Asp Thr Gly Pro Cys Val Asn Gln 
        435                 440                 445             


Lys Gln Glu Pro Gly Pro Ala Gln Glu Glu Ala Glu Leu Gly Gly Gln 
    450                 455                 460                 


Asn Leu Glu Arg Asp Leu Glu Gly Phe Arg Val Ser Pro Gln Ala Ser 
465                 470                 475                 480 


Val Val Leu Glu His Arg Glu Ile Ala Asp Asp Pro Leu Gln Glu Pro 
                485                 490                 495     


Gly Ala Gln Gln Gly Ile Pro Asp Thr Thr Ser Glu Leu Ala Gly Gln 
            500                 505                 510         


Arg Asp His Leu Pro His Ser Ala Asp Gln Gly Thr Trp Ala Asp Ser 
        515                 520                 525             


Leu Ala Val Glu Leu Asp Phe Leu Leu Asp Ser Gln Ile Gln Asp Ala 
    530                 535                 540                 


Leu Asp Ala Ser Asp Phe Glu Ala Pro Pro Glu Gln Leu Phe Pro Ser 
545                 550                 555                 560 


Gly Asn Lys Pro Gly Pro Cys Trp Pro Gly Pro Ser Ser His Ala Asn 
                565                 570                 575     


Gly Asp Pro Val Ala Val Ala Lys Ala Gln Pro Ser Arg Leu Ile Met 
            580                 585                 590         


Gly Thr His Arg Asp Leu Glu Ala Phe Lys Arg Leu Asn Tyr Arg Lys 
        595                 600                 605             


Thr Lys Leu Gly Gly Lys Ala Pro Leu Pro Tyr Pro Ser Lys Gly Pro 
    610                 615                 620                 


Gly Asn Ile Pro Arg Gly Asp Pro Pro Trp Arg Glu Leu 
625                 630                 635         


<210>  1353
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C19orf68__Homo_sapiens__NP_955373

<400>  1353

Met Glu Arg Pro Glu Pro Pro Pro Gly Thr Ala Ala Gly Gln Glu Glu 
1               5                   10                  15      


Gln Glu Leu Arg Glu Arg Ala Phe Phe Ser Trp Ala Glu Phe Ser Arg 
            20                  25                  30          


Phe Phe Asp Ala Trp Cys Gln Gln Arg Leu Ala Leu Phe Phe Val Lys 
        35                  40                  45              


Ser Ser Met His Leu Ala Arg Cys Arg Trp Ala Ser Ala Pro Pro Leu 
    50                  55                  60                  


Tyr Thr Leu Ile Asp Val Leu Lys Tyr Ser Tyr Val Arg Leu Val Cys 
65                  70                  75                  80  


Lys Asp Val Arg Ala Pro Ser Arg Pro Ala Val Gly Pro Pro Gln Pro 
                85                  90                  95      


Gly Cys Pro Ala Phe Ile Ile Val Lys Leu Ser Pro Leu Arg Asp Arg 
            100                 105                 110         


Leu Val Val Thr Glu Cys Gln Leu Thr His Ser His Pro Ala Cys Pro 
        115                 120                 125             


Leu Glu Phe Ala Tyr Tyr Phe Arg Pro Gly His Leu Leu Ala Asn Ala 
    130                 135                 140                 


Cys Leu Pro Val Arg Thr Thr Asn Lys Ile Ser Lys Gln Phe Val Ala 
145                 150                 155                 160 


Pro Ala Asp Val Arg Arg Leu Leu Ser Tyr Cys Lys Gly Arg Asp His 
                165                 170                 175     


Gly Val Leu Asp Ala Leu His Val Leu Glu Gly Leu Phe Arg Thr Asp 
            180                 185                 190         


Pro Glu Ala Lys Val Lys Leu Val Phe Val Glu Asp Gln Ala Val Val 
        195                 200                 205             


Glu Thr Val Phe Phe Leu Thr Ser Arg Thr Arg Ala Leu Leu Arg Arg 
    210                 215                 220                 


Phe Pro Arg Met Leu Leu Val Asp Arg Leu Pro Gly Leu Gln Gly Ala 
225                 230                 235                 240 


Leu Asp Leu Leu Ala Val Leu Cys Val Asp Gly Ser Gly Arg Ala Arg 
                245                 250                 255     


Gln Ala Ala Cys Cys Val Ala Arg Pro Gly Thr Pro Ser Leu Leu Arg 
            260                 265                 270         


Phe Ala Leu Ala Ser Leu Leu Gln Ser Ala Pro Asp Val Lys Gly Arg 
        275                 280                 285             


Val Arg Cys Leu Thr Ala Gly Pro Glu Val Ala Ala Gln Leu Pro Ala 
    290                 295                 300                 


Val Arg Gln Leu Leu Pro Cys Ala Arg Val Gln Ile Cys Arg Ala Gln 
305                 310                 315                 320 


Gly Leu Glu Thr Leu Phe Ser Lys Ala Gln Glu Leu Gly Gly Ala Gly 
                325                 330                 335     


Arg Glu Asp Pro Gly Leu Trp Ser Arg Leu Cys Arg Leu Ala Gly Ala 
            340                 345                 350         


Ser Ser Pro Ala Ala Tyr Asp Glu Ala Leu Ala Glu Leu His Ala His 
        355                 360                 365             


Gly Pro Ala Ala Phe Val Asp Tyr Phe Glu Arg Asn Trp Glu Pro Arg 
    370                 375                 380                 


Arg Asp Met Trp Val Arg Phe Arg Ala Phe Glu Ala Ala Arg Asp Leu 
385                 390                 395                 400 


Asp Ala Cys Ala Leu Val Arg Gly His Arg Arg Arg Leu Leu Arg Arg 
                405                 410                 415     


Leu Ser Pro Ser Arg Gly Val Ala Gln Cys Leu Arg Asp Leu Val Ala 
            420                 425                 430         


Met Gln Trp Ala Asp Ala Ala Gly Glu Ala Val Pro Glu Gly Pro Asp 
        435                 440                 445             


Gly Gly Gly Pro Trp Leu Glu Asp Glu Pro Gly Arg Gly Ala Gln Gly 
    450                 455                 460                 


Glu Asn Glu Arg Val Arg Gly Leu Glu Thr Gly Asp Trp Gly Gly Ala 
465                 470                 475                 480 


Pro Lys Glu Gly Ser Ile Trp Arg Gly Ala Gln Met Glu Lys Glu Trp 
                485                 490                 495     


Ala Arg Ala Leu Glu Thr Arg Asp Trp Gly Gly Ala Gln Phe Glu Gly 
            500                 505                 510         


Glu Lys Gly Arg Ala Leu Gln Ile Arg Asp Trp Arg Gly Gly Arg Leu 
        515                 520                 525             


Glu Asn Gln Lys Pro Arg Gly Leu Glu Gly Gly Val Leu Arg Gly Ser 
    530                 535                 540                 


Lys Leu Glu Lys Gly His Leu Arg Gly Pro Glu Ile Arg Asp Trp Arg 
545                 550                 555                 560 


Gly Pro Gln Leu Glu Gly Glu Lys Asp Trp Gly Leu Glu Gly Tyr Val 
                565                 570                 575     


Trp Arg Gly Ser Gln Leu Glu Asp Gln Ala Leu Arg Gly Leu Glu Gly 
            580                 585                 590         


Tyr Thr Trp Arg Val Ala Gln Leu Glu Asp Arg Arg Ser Thr Thr Asp 
        595                 600                 605             


Leu Arg Gly Thr Gln Phe Asp Tyr Glu Arg Val Arg Ser Leu Glu Gly 
    610                 615                 620                 


Ser Pro Trp Arg Gly Ala Gln Leu His Asp Glu Arg Ala Gly Gly Leu 
625                 630                 635                 640 


Arg Thr Ala Glu Trp Lys Gly Pro Gln Ser Glu Val Glu Lys Gly Arg 
                645                 650                 655     


Gly Leu Glu Val Arg Asn Leu Arg Gly Ile Pro Leu Glu Lys Ser Leu 
            660                 665                 670         


Glu Leu Ala Pro Glu Asn Gly Asp Gln Arg Gly Pro Gln Trp Glu Asp 
        675                 680                 685             


Glu Arg Arg Arg Gly Pro Glu Ile Ala Glu Glu Arg Gly Ala Arg Val 
    690                 695                 700                 


Gly Val Lys Arg Arg Arg Gly Leu Glu Asp Ile Val Leu Val Gln Leu 
705                 710                 715                 720 


Gly Asp Thr Arg Val Thr Gly Met Glu Asn Gly Asp Gly Gly Gly Ala 
                725                 730                 735     


Arg Ser Val Gly Pro Lys Ser Arg Ala Gly Arg Gly Met Glu Trp Gly 
            740                 745                 750         


Asp Ala Gly Gly Arg Cys Leu Gly Leu Gly Asn Gly Val Val Ser Gly 
        755                 760                 765             


Thr Pro Val Gly Thr Val Leu Glu Gly Ser Pro Glu Trp Ala Ala Ala 
    770                 775                 780                 


Arg Ser Glu His Leu Ala Ala Gly Asp Gly Leu Gln Glu Gly Gly Glu 
785                 790                 795                 800 


Asp Gly Pro Arg Glu Pro Lys Arg Leu Cys Arg Pro Pro Gly Glu Glu 
                805                 810                 815     


Glu Val Asp Trp Glu Pro Leu Ala Lys Phe Arg Ala Ala Cys Gly Pro 
            820                 825                 830         


Glu Leu Ala Asp Leu Val Ala Glu Glu Leu Ala Phe Ala Arg Gln His 
        835                 840                 845             


Gly Thr Arg Gly Phe His Trp Thr Gly Ala Gly Phe Ala Leu Lys Asp 
    850                 855                 860                 


Gly Thr Ser Asp Phe Phe Leu Asp Gly Ala Leu Thr Arg Cys Ser Cys 
865                 870                 875                 880 


Ser Ile His Ala Ala Arg Arg Leu Pro Cys Arg His Leu Phe Ala Ala 
                885                 890                 895     


Arg Leu Leu Thr Gly Ala Ala Leu Phe His Met Asp Leu Leu Arg Asp 
            900                 905                 910         


Cys Trp Gly Arg Ala Pro Glu Pro 
        915                 920 


<210>  1354
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1D__Homo_sapiens__NP_775269

<400>  1354

Met Ala Gly Glu Glu Ile Asn Glu Asp Tyr Pro Val Glu Ile His Glu 
1               5                   10                  15      


Tyr Leu Ser Ala Phe Glu Asn Ser Ile Gly Ala Val Asp Glu Met Leu 
            20                  25                  30          


Lys Thr Met Met Ser Val Ser Arg Asn Glu Leu Leu Gln Lys Leu Asp 
        35                  40                  45              


Pro Leu Glu Gln Ala Lys Val Asp Leu Val Ser Ala Tyr Thr Leu Asn 
    50                  55                  60                  


Ser Met Phe Trp Val Tyr Leu Ala Thr Gln Gly Val Asn Pro Lys Glu 
65                  70                  75                  80  


His Pro Val Lys Gln Glu Leu Glu Arg Ile Arg Val Tyr Met Asn Arg 
                85                  90                  95      


Val Lys Glu Ile Thr Asp Lys Lys Lys Ala Gly Lys Leu Asp Arg Gly 
            100                 105                 110         


Ala Ala Ser Arg Phe Val Lys Asn Ala Leu Trp Glu Pro Lys Ser Lys 
        115                 120                 125             


Asn Ala Ser Lys Val Ala Asn Lys Gly Lys Ser Lys Ser 
    130                 135                 140     


<210>  1355
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1GALT1C1__Homo_sapiens__NP_689905

<400>  1355

Met Leu Ser Glu Ser Ser Ser Phe Leu Lys Gly Val Met Leu Gly Ser 
1               5                   10                  15      


Ile Phe Cys Ala Leu Ile Thr Met Leu Gly His Ile Arg Ile Gly His 
            20                  25                  30          


Gly Asn Arg Met His His His Glu His His His Leu Gln Ala Pro Asn 
        35                  40                  45              


Lys Glu Asp Ile Leu Lys Ile Ser Glu Asp Glu Arg Met Glu Leu Ser 
    50                  55                  60                  


Lys Ser Phe Arg Val Tyr Cys Ile Ile Leu Val Lys Pro Lys Asp Val 
65                  70                  75                  80  


Ser Leu Trp Ala Ala Val Lys Glu Thr Trp Thr Lys His Cys Asp Lys 
                85                  90                  95      


Ala Glu Phe Phe Ser Ser Glu Asn Val Lys Val Phe Glu Ser Ile Asn 
            100                 105                 110         


Met Asp Thr Asn Asp Met Trp Leu Met Met Arg Lys Ala Tyr Lys Tyr 
        115                 120                 125             


Ala Phe Asp Lys Tyr Arg Asp Gln Tyr Asn Trp Phe Phe Leu Ala Arg 
    130                 135                 140                 


Pro Thr Thr Phe Ala Ile Ile Glu Asn Leu Lys Tyr Phe Leu Leu Lys 
145                 150                 155                 160 


Lys Asp Pro Ser Gln Pro Phe Tyr Leu Gly His Thr Ile Lys Ser Gly 
                165                 170                 175     


Asp Leu Glu Tyr Val Gly Met Glu Gly Gly Ile Val Leu Ser Val Glu 
            180                 185                 190         


Ser Met Lys Arg Leu Asn Ser Leu Leu Asn Ile Pro Glu Lys Cys Pro 
        195                 200                 205             


Glu Gln Gly Gly Met Ile Trp Lys Ile Ser Glu Asp Lys Gln Leu Ala 
    210                 215                 220                 


Val Cys Leu Lys Tyr Ala Gly Val Phe Ala Glu Asn Ala Glu Asp Ala 
225                 230                 235                 240 


Asp Gly Lys Asp Val Phe Asn Thr Lys Ser Val Gly Leu Ser Ile Lys 
                245                 250                 255     


Glu Ala Met Thr Tyr His Pro Asn Gln Val Val Glu Gly Cys Cys Ser 
            260                 265                 270         


Asp Met Ala Val Thr Phe Asn Gly Leu Thr Pro Asn Gln Met His Val 
        275                 280                 285             


Met Met Tyr Gly Val Tyr Arg Leu Arg Ala Phe Gly His Ile Phe Asn 
    290                 295                 300                 


Asp Ala Leu Val Phe Leu Pro Pro Asn Gly Ser Asp Asn Asp 
305                 310                 315             


<210>  1356
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1GALT1__Homo_sapiens__XP_005249869

<400>  1356

Met Ser Glu Ile His Phe Arg Glu Met Ala Ser Lys Ser Trp Leu Asn 
1               5                   10                  15      


Phe Leu Thr Phe Leu Cys Gly Ser Ala Ile Gly Phe Leu Leu Cys Ser 
            20                  25                  30          


Gln Leu Phe Ser Ile Leu Leu Gly Glu Lys Val Asp Thr Gln Pro Asn 
        35                  40                  45              


Val Leu His Asn Asp Pro His Ala Arg His Ser Asp Asp Asn Gly Gln 
    50                  55                  60                  


Asn His Leu Glu Gly Gln Met Asn Phe Asn Ala Asp Ser Ser Gln His 
65                  70                  75                  80  


Lys Asp Glu Asn Thr Asp Ile Ala Glu Asn Leu Tyr Gln Lys Val Arg 
                85                  90                  95      


Ile Leu Cys Trp Val Met Thr Gly Pro Gln Asn Leu Glu Lys Lys Ala 
            100                 105                 110         


Lys His Val Lys Ala Thr Trp Ala Gln Arg Cys Asn Lys Val Leu Phe 
        115                 120                 125             


Met Ser Ser Glu Glu Asn Lys Asp Phe Pro Ala Val Gly Leu Lys Thr 
    130                 135                 140                 


Lys Glu Gly Arg Asp Gln Leu Tyr Trp Lys Thr Ile Lys Ala Phe Gln 
145                 150                 155                 160 


Tyr Val His Glu His Tyr Leu Glu Asp Ala Asp Trp Phe Leu Lys Ala 
                165                 170                 175     


Asp Asp Asp Thr Tyr Val Ile Leu Asp Asn Leu Arg Trp Leu Leu Ser 
            180                 185                 190         


Lys Tyr Asp Pro Glu Glu Pro Ile Tyr Phe Gly Arg Arg Phe Lys Pro 
        195                 200                 205             


Tyr Val Lys Gln Gly Tyr Met Ser Gly Gly Ala Gly Tyr Val Leu Ser 
    210                 215                 220                 


Lys Glu Ala Leu Lys Arg Phe Val Asp Ala Phe Lys Thr Asp Lys Cys 
225                 230                 235                 240 


Thr His Ser Ser Ser Ile Glu Asp Leu Ala Leu Gly Arg Cys Met Glu 
                245                 250                 255     


Ile Met Asn Val Glu Ala Gly Asp Ser Arg Asp Thr Ile Gly Lys Glu 
            260                 265                 270         


Thr Phe His Pro Phe Val Pro Glu His His Leu Ile Lys Gly Tyr Leu 
        275                 280                 285             


Pro Arg Thr Phe Trp Tyr Trp Asn Tyr Asn Tyr Tyr Pro Pro Val Glu 
    290                 295                 300                 


Gly Pro Gly Cys Cys Ser Asp Leu Ala Val Ser Phe His Tyr Val Asp 
305                 310                 315                 320 


Ser Thr Thr Met Tyr Glu Leu Glu Tyr Leu Val Tyr His Leu Arg Pro 
                325                 330                 335     


Tyr Gly Tyr Leu Tyr Arg Tyr Gln Pro Thr Leu Pro Glu Arg Ile Leu 
            340                 345                 350         


Lys Glu Ile Ser Gln Ala Asn Lys Asn Glu Asp Thr Lys Val Lys Leu 
        355                 360                 365             


Gly Asn Pro 
    370     


<210>  1357
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf106__Homo_sapiens__NP_001136041

<400>  1357

Met Glu Ser Lys Asp Glu Val Ser Asp Thr Asp Ser Gly Ile Ile Leu 
1               5                   10                  15      


Gln Ser Gly Pro Asp Ser Pro Val Ser Pro Met Lys Glu Leu Thr His 
            20                  25                  30          


Ala Val His Lys Gln Gln Arg Ala Leu Glu Ala Arg Leu Glu Ala Cys 
        35                  40                  45              


Leu Glu Glu Leu Arg Arg Leu Cys Leu Arg Glu Ala Glu Leu Thr Gly 
    50                  55                  60                  


Thr Leu Pro Ala Glu Tyr Pro Leu Lys Pro Gly Glu Lys Ala Pro Lys 
65                  70                  75                  80  


Val Arg Arg Arg Ile Gly Ala Ala Tyr Lys Leu Asp Asp Trp Ala Leu 
                85                  90                  95      


His Arg Glu Asp Pro Leu Ser Ser Leu Glu Arg Gln Leu Ala Leu Gln 
            100                 105                 110         


Leu Gln Ile Thr Glu Ala Ala Arg Arg Leu Cys Leu Glu Glu Asn Leu 
        115                 120                 125             


Ser Arg Gln Ala Arg Arg Gln Arg Lys His Ser Met Leu Gln Glu Glu 
    130                 135                 140                 


Lys Lys Leu Gln Glu Leu Gln Arg Cys Leu Val Glu Arg Arg Arg Asn 
145                 150                 155                 160 


Ser Glu Pro Pro Pro Ala Ala Ala Leu Pro Leu Gly Arg Glu Leu Ser 
                165                 170                 175     


Ala Ser Asp Asp Ser Ser Leu Ser Asp Gly Leu Leu Leu Glu Glu Glu 
            180                 185                 190         


Glu Ser Gln Val Pro Lys Pro Pro Pro Glu Ser Pro Ala Pro Pro Ser 
        195                 200                 205             


Arg Pro Leu Pro Pro Gln Thr Leu Glu Gly Leu Gln Pro Thr Gly Pro 
    210                 215                 220                 


Glu Ala Gly Ser Pro Glu Arg Ala Pro Val Gln Asn Ser Pro Trp Lys 
225                 230                 235                 240 


Glu Thr Ser Leu Asp His Pro Tyr Glu Lys Pro Arg Lys Ser Ser Glu 
                245                 250                 255     


Pro Trp Ser Glu Ser Ser Ser Pro Ala Thr Thr Pro Gln Asp Gly Pro 
            260                 265                 270         


Ser Ala Ser Ser Leu Trp Leu Leu Glu Pro Ala Ser Tyr His Val Val 
        275                 280                 285             


Pro Ile Arg Gly Val Pro Gly Gln Trp Gln Gly Arg Thr Ser Ala Pro 
    290                 295                 300                 


Ala Thr Pro Glu Ile Gln Gly Arg Arg Gly Gln Ser Gln Ser Leu Arg 
305                 310                 315                 320 


Val Asp Ser Phe Arg Ala Gly Pro Glu Gly Arg Gly Arg Ser Ala Phe 
                325                 330                 335     


Pro Arg Arg Arg Pro Thr His Tyr Thr Val Thr Val Pro Asp Ser Cys 
            340                 345                 350         


Phe Pro Ala Thr Lys Pro Pro Leu Pro His Ala Ala Cys His Ser Cys 
        355                 360                 365             


Ser Glu Asp Ser Gly Ser Asp Val Ser Ser Ile Ser His Pro Thr Ser 
    370                 375                 380                 


Pro Gly Ser Ser Ser Pro Asp Ile Ser Phe Leu Gln Pro Leu Ser Pro 
385                 390                 395                 400 


Pro Lys Thr His Arg His Arg Gly Ala Trp Val Pro Ala Gly Ser Arg 
                405                 410                 415     


Glu Leu Val Ala His His Pro Lys Leu Leu Leu Pro Pro Gly Tyr Phe 
            420                 425                 430         


Pro Ala Gly Arg Tyr Val Val Val Ala Glu Ser Pro Leu Pro Pro Gly 
        435                 440                 445             


Glu Trp Glu Leu Arg Arg Ala Ala Pro Gly Pro Ala Tyr Glu Glu Glu 
    450                 455                 460                 


Gly Thr Pro Leu Arg Tyr Gln Arg Leu Val Pro Ser Arg Ser Arg Ile 
465                 470                 475                 480 


Val Arg Thr Pro Ser Leu Lys Asp Ser Pro Ala Gly Arg Gly Leu Ser 
                485                 490                 495     


Lys Ala Ala Val Ser Glu Glu Leu Lys Trp Trp His Glu Arg Ala Arg 
            500                 505                 510         


Leu Arg Ser Thr Arg Pro His Ser Leu Asp Arg Gln Gly Ala Phe Arg 
        515                 520                 525             


Val Arg Ser Leu Pro Leu Gly Arg Glu Gly Phe Gly Arg Ala Leu Gly 
    530                 535                 540                 


Pro Arg Ala Gln Val Pro Thr Val Cys Val Leu Arg Arg Ser Pro Asp 
545                 550                 555                 560 


Gly Ala Pro Val Gln Val Phe Val Pro Glu Lys Gly Glu Ile Ile Ser 
                565                 570                 575     


Gln Val 
        


<210>  1358
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf109__Homo_sapiens__NP_001289959

<400>  1358

Met Ser Glu Lys Arg Arg Arg Leu Asp Ala Arg Asn Pro Leu Lys Gln 
1               5                   10                  15      


Glu Thr Ala Leu Ser Arg Leu Pro Phe Pro Arg Gly Asn Gln Gly Leu 
            20                  25                  30          


Leu Gln Lys Ala Glu Ala Gly Arg Ala Arg Trp Leu Thr Pro Val Ile 
        35                  40                  45              


Pro Ala Leu Trp Lys Thr Glu Ala Gly Gly Ser Pro Glu Lys Met Thr 
    50                  55                  60                  


Gln Asp Arg Pro Leu Leu Ala Val Gln Glu Ala Leu Lys Lys Cys Phe 
65                  70                  75                  80  


Pro Val Val Glu Glu Gln Gln Gly Leu Trp Gln Ser Ala Leu Arg Asp 
                85                  90                  95      


Cys Gln Pro Leu Leu Ser Ser Leu Ser Asn Leu Ala Glu Gln Leu Gln 
            100                 105                 110         


Ala Ala Gln Asn Leu Arg Phe Glu Asp Val Pro Ala Leu Arg Ala Phe 
        115                 120                 125             


Pro Asp Leu Lys Glu Arg Leu Arg Arg Lys Gln Leu Val Ala Gly Asp 
    130                 135                 140                 


Ile Val Leu Asp Lys Leu Gly Glu Arg Leu Ala Ile Leu Leu Lys Val 
145                 150                 155                 160 


Arg Asp Met Val Ser Ser His Val Glu Arg Val Phe Gln Ile Tyr Glu 
                165                 170                 175     


Gln His Ala Asp Thr Val Gly Ile Asp Ala Val Leu Gln Pro Ser Ala 
            180                 185                 190         


Val Ser Pro Ser Val Ala Asp Met Leu Glu Trp Leu Gln Asp Ile Glu 
        195                 200                 205             


Arg His Tyr Arg Lys Ser Tyr Leu Lys Arg Lys Tyr Leu Leu Ser Ser 
    210                 215                 220                 


Ile Gln Trp Gly Asp Leu Ala Asn Ile Gln Ala Leu Pro Lys Ala Trp 
225                 230                 235                 240 


Asp Arg Ile Ser Lys Asp Glu His Gln Asp Leu Val Gln Asp Ile Leu 
                245                 250                 255     


Leu Asn Val Ser Phe Phe Leu Glu Glu 
            260                 265 


<210>  1359
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf110__Homo_sapiens__NP_848645

<400>  1359

Met Glu Arg His Met Val Arg Gly Gln Leu Tyr Lys His Phe Asp Leu 
1               5                   10                  15      


Glu Arg Lys Asn Ala Lys Gln Ala Glu Ala Arg Leu Asp Gln Arg Leu 
            20                  25                  30          


Gln Arg Leu Lys Val Ile Cys Leu Tyr His Val Lys Leu Leu Thr Trp 
        35                  40                  45              


Glu Gln Arg Gln Leu Gln Lys Glu Leu Gln Arg Leu Gln Gln Ala Glu 
    50                  55                  60                  


Thr Met Lys Lys Lys Phe Ser Ser Tyr Leu Gly Asn Gly Phe Gln Lys 
65                  70                  75                  80  


Arg Pro Glu Asp Val Leu Val Phe Ser Pro Gln Gly Arg Gln Lys His 
                85                  90                  95      


Arg Ala Pro Gln Ala Lys Lys Met Arg Ala Leu Ala Thr Arg Met Ala 
            100                 105                 110         


Gln Asp Thr Cys Lys Ser Lys Ser Gln Val Pro Pro Ser His Asp Ala 
        115                 120                 125             


Gly Leu Lys Asp Pro Met Lys Ser Lys Lys Gln Pro Leu Ser Gln Asn 
    130                 135                 140                 


Asn Arg Thr Ala Cys Phe Ile Lys Glu Gln Pro Gln Ala Gln Glu Lys 
145                 150                 155                 160 


Asp Ser Val Asn Pro Ser Lys Asp Val Asp Pro Ser Lys Gly Ile Ser 
                165                 170                 175     


Val Pro Cys Gln Asn Gln Glu Val Ser Thr Asn Thr Ile Glu Gln Gly 
            180                 185                 190         


Pro Ser Ser Ser Pro Ala Ser Asp Ser Gly Met Ala Cys Ala Asp Glu 
        195                 200                 205             


Thr Arg Ser Lys Asp Val Ala Leu Lys Pro Asp Gly Asn Thr Gly Lys 
    210                 215                 220                 


Gln Ile Pro Pro Lys His Met Glu Cys Ala Gly Ser Phe Glu Gly Glu 
225                 230                 235                 240 


Phe Thr Lys Pro Thr Phe Leu Glu Leu Leu Ser Lys Ala Arg Asn Ala 
                245                 250                 255     


His Tyr Leu Arg His Arg Val Pro Pro Glu Ser Glu Arg Leu Leu Ser 
            260                 265                 270         


Ile Gly Glu Ile Phe Gly His Gly Glu Ser Ser Ser Ser Arg Ala Gly 
        275                 280                 285             


Lys Glu Cys Glu Asn Arg Val Pro Ser Lys Phe Leu Pro Leu 
    290                 295                 300         


<210>  1360
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf112__Homo_sapiens__XP_005245374

<400>  1360

Met Ser Gln Glu Gly Ala Val Pro Ala Ser Ala Val Pro Leu Glu Glu 
1               5                   10                  15      


Leu Ser Ser Trp Pro Glu Glu Leu Cys Arg Arg Glu Leu Pro Ser Val 
            20                  25                  30          


Leu Pro Arg Leu Leu Ser Leu Ser Gln His Ser Asp Ser Trp Ile Glu 
        35                  40                  45              


His Ile Gln Ile Leu Lys Ile Ile Val Glu Met Phe Leu Pro His Met 
    50                  55                  60                  


Asn His Leu Thr Leu Glu Gln Thr Phe Phe Ser Gln Val Leu Pro Lys 
65                  70                  75                  80  


Thr Val Lys Leu Phe Asp Asp Met Met Tyr Glu Leu Thr Ser Gln Ala 
                85                  90                  95      


Arg Gly Leu Ser Ser Gln Asn Leu Glu Ile Gln Thr Thr Leu Arg Asn 
            100                 105                 110         


Ile Leu Gln Thr Met Val Gln Leu Leu Gly Ala Leu Thr Gly Cys Val 
        115                 120                 125             


Gln His Ile Cys Ala Thr Gln Glu Ser Ile Ile Leu Glu Asn Ile Gln 
    130                 135                 140                 


Ser Leu Pro Ser Ser Val Leu His Ile Ile Lys Ser Thr Phe Val His 
145                 150                 155                 160 


Cys Lys Asn Ser Glu Ser Val Tyr Ser Gly Cys Leu His Leu Val Ser 
                165                 170                 175     


Asp Leu Leu Gln Ala Leu Phe Lys Glu Ala Tyr Ser Leu Gln Lys Gln 
            180                 185                 190         


Leu Met Glu Leu Leu Asp Met Val Cys Met Asp Pro Leu Val Asp Asp 
        195                 200                 205             


Asn Asp Asp Ile Leu Asn Met Val Ile Val Ile His Ser Leu Leu Asp 
    210                 215                 220                 


Ile Cys Ser Val Ile Ser Ser Met Asp His Ala Phe His Ala Asn Thr 
225                 230                 235                 240 


Trp Lys Phe Ile Ile Lys Gln Ser Leu Lys His Gln Ser Ile Ile Lys 
                245                 250                 255     


Ser Gln Leu Lys His Lys Asp Ile Ile Thr Ser Leu Cys Glu Asp Ile 
            260                 265                 270         


Leu Phe Ser Phe His Ser Cys Leu Gln Leu Ala Glu Gln Met Thr Gln 
        275                 280                 285             


Ser Asp Ala Gln Asp Asn Ala Asp Tyr Arg Leu Phe Gln Lys Thr Leu 
    290                 295                 300                 


Lys Leu Cys Arg Phe Phe Ala Asn Ser Leu Leu His Tyr Ala Lys Glu 
305                 310                 315                 320 


Phe Leu Pro Phe Leu Ser Asp Ser Cys Cys Thr Leu His Gln Leu Tyr 
                325                 330                 335     


Leu Gln Ile His Ser Lys Phe Pro Pro Ser Leu Tyr Ala Thr Arg Ile 
            340                 345                 350         


Ser Lys Ala His Gln Glu Glu Ile Ala Gly Ala Phe Leu Val Thr Leu 
        355                 360                 365             


Asp Pro Leu Ile Ser Gln Leu Leu Thr Phe Gln Pro Phe Met Gln Val 
    370                 375                 380                 


Val Leu Asp Ser Lys Leu Asp Leu Pro Cys Glu Leu Gln Phe Pro Gln 
385                 390                 395                 400 


Cys Leu Leu Leu Val Val Val Met Asp Lys Leu Pro Ser Gln Pro Lys 
                405                 410                 415     


Glu Val Gln Thr Leu Trp Cys Thr Asp Ser Gln Val Ser Glu Thr Thr 
            420                 425                 430         


Thr Arg Ile Ser Leu Leu Lys Ala Val Phe Tyr Ser Phe Glu Gln Cys 
        435                 440                 445             


Ser Gly Glu Leu Ser Leu Pro Val His Leu Gln Gly Leu Lys Ser Lys 
    450                 455                 460                 


Gly Lys Ala Glu Val Ala Val Thr Leu Tyr Gln His Val Cys Val His 
465                 470                 475                 480 


Leu Cys Thr Phe Ile Thr Ser Phe His Pro Ser Leu Phe Ala Glu Leu 
                485                 490                 495     


Asp Ala Ala Leu Leu Asn Ala Val Leu Ser Ala Asn Met Ile Thr Ser 
            500                 505                 510         


Leu Leu Ala Met Asp Ala Trp Cys Phe Leu Ala Arg Tyr Gly Thr Ala 
        515                 520                 525             


Glu Leu Cys Ala His His Val Thr Ile Val Ala His Leu Ile Lys Ser 
    530                 535                 540                 


Cys Pro Gly Glu Cys Tyr Gln Leu Ile Asn Leu Ser Ile Leu Leu Lys 
545                 550                 555                 560 


Arg Leu Phe Phe Phe Met Ala Pro Pro His Gln Leu Glu Phe Ile Gln 
                565                 570                 575     


Lys Phe Ser Pro Lys Glu Ala Glu Asn Leu Pro Leu Trp Gln His Ile 
            580                 585                 590         


Ser Phe Gln Ala Leu Pro Pro Glu Leu Arg Glu Gln Thr Val His Glu 
        595                 600                 605             


Val Thr Thr Val Gly Thr Ala Glu Cys Arg Lys Trp Leu Ser Arg Ser 
    610                 615                 620                 


Arg Thr Leu Gly Glu Leu Glu Ser Leu Asn Thr Val Leu Ser Ala Leu 
625                 630                 635                 640 


Leu Ala Val Cys Asn Ser Ala Gly Glu Ala Leu Asp Thr Gly Lys Gln 
                645                 650                 655     


Thr Ala Ile Ile Glu Val Val Ser Gln Leu Trp Ala Phe Leu Asn Ile 
            660                 665                 670         


Lys Gln Val Ala Asp Gln Pro Tyr Val Gln Gln Thr Phe Ser Leu Leu 
        675                 680                 685             


Leu Pro Leu Leu Gly Phe Phe Ile Gln Thr Leu Asp Pro Lys Leu Ile 
    690                 695                 700                 


Leu Gln Ala Val Thr Leu Gln Thr Ser Leu Leu Lys Leu Glu Leu Pro 
705                 710                 715                 720 


Asp Tyr Val Arg Leu Ala Met Leu Asp Phe Val Ser Ser Leu Gly Lys 
                725                 730                 735     


Leu Phe Ile Pro Glu Ala Ile Gln Asp Arg Ile Leu Pro Asn Leu Ser 
            740                 745                 750         


Cys Met Phe Ala Leu Leu Leu Ala Asp Arg Ser Trp Leu Leu Glu Gln 
        755                 760                 765             


His Thr Leu Glu Ala Phe Thr Gln Phe Ala Glu Gly Thr Asn His Glu 
    770                 775                 780                 


Glu Ile Val Pro Gln Cys Leu Ser Ser Glu Glu Thr Lys Asn Lys Val 
785                 790                 795                 800 


Val Ser Phe Leu Glu Lys Thr Gly Phe Val Asp Glu Thr Glu Ala Ala 
                805                 810                 815     


Lys Val Glu Arg Val Lys Gln Glu Lys Gly Ile Phe Trp Glu Pro Phe 
            820                 825                 830         


Ala Asn Val Thr Val Glu Glu Ala Lys Arg Ser Ser Leu Gln Pro Tyr 
        835                 840                 845             


Ala Lys Arg Ala Arg Gln Glu Phe Pro Trp Glu Glu Glu Tyr Arg Ser 
    850                 855                 860                 


Ala Leu His Thr Ile Ala Gly Ala Leu Glu Ala Thr Glu Ser Leu Leu 
865                 870                 875                 880 


Gln Lys Gly Pro Ala Pro Ala Trp Leu Ser Met Glu Met Glu Ala Leu 
                885                 890                 895     


Gln Glu Arg Met Asp Lys Leu Lys Arg Tyr Ile His Thr Leu Gly 
            900                 905                 910     


<210>  1361
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf115__Homo_sapiens__NP_078985

<400>  1361

Met Thr Val Gly Ala Arg Leu Arg Ser Lys Ala Glu Ser Ser Leu Leu 
1               5                   10                  15      


Arg Arg Gly Pro Arg Gly Arg Gly Arg Thr Glu Gly Asp Glu Glu Ala 
            20                  25                  30          


Ala Ala Ile Leu Glu His Leu Glu Tyr Ala Asp Glu Ala Glu Ala Ala 
        35                  40                  45              


Ala Glu Ser Gly Thr Ser Ala Ala Asp Glu Arg Gly Pro Gly Thr Arg 
    50                  55                  60                  


Gly Ala Arg Arg Val His Phe Ala Leu Leu Pro Glu Arg Tyr Glu Pro 
65                  70                  75                  80  


Leu Glu Glu Pro Ala Pro Ser Glu Gln Pro Arg Lys Arg Tyr Arg Arg 
                85                  90                  95      


Lys Leu Lys Lys Tyr Gly Lys Asn Val Gly Lys Val Ile Ile Lys Gly 
            100                 105                 110         


Cys Arg Tyr Val Val Ile Gly Leu Gln Gly Phe Ala Ala Ala Tyr Ser 
        115                 120                 125             


Ala Pro Phe Ala Val Ala Thr Ser Val Val Ser Phe Val Arg 
    130                 135                 140         


<210>  1362
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf127__Homo_sapiens__XP_011539059

<400>  1362

Met Ser Thr Phe Pro Thr Ser Ser His Ser Gly Leu Phe Ser Pro Ser 
1               5                   10                  15      


Ser Gly His Leu Ile Pro Leu Cys Leu Ile Pro Pro Leu Leu Ser Ser 
            20                  25                  30          


Val Pro Thr Leu Ala Met Arg Phe Arg Asn Ala Arg Asp Lys Glu Lys 
        35                  40                  45              


Phe Ala Phe Ala Gly Arg Cys Trp Val Ser Phe Gln Pro Glu Ser Glu 
    50                  55                  60                  


Val Leu Val His Ile Pro Lys Gln Arg Leu Gly Leu Val Lys Arg Gly 
65                  70                  75                  80  


Ser Tyr Ile Glu Glu Thr Leu Ser Leu Arg Phe Leu Arg Val His Gln 
                85                  90                  95      


Ser Asn Ile Phe Met Val Thr Glu Asn Lys Asp Phe Val Val Val Ser 
            100                 105                 110         


Ile Pro Ala Ala Gly Val Leu Gln Val Gln Arg Cys Gln Glu Val Gly 
        115                 120                 125             


Gly Thr Pro Gly Thr Gln Ala Phe Tyr Arg Val Asp Leu Ser Leu Glu 
    130                 135                 140                 


Phe Ala Glu Met Ala Ala Pro Val Leu Trp Thr Val Glu Ser Phe Phe 
145                 150                 155                 160 


Gln Cys Val Gly Ser Gly Thr Glu Ser Pro Ala Ser Thr Ala Ala Leu 
                165                 170                 175     


Arg Thr Thr Pro Ser Pro Pro Ser Pro Gly Pro Glu Thr Pro Pro Ala 
            180                 185                 190         


Gly Val Pro Pro Ala Ala Ser Ser Gln Val Trp Ala Ala Gly Pro Ala 
        195                 200                 205             


Ala Gln Glu Trp Leu Ser Arg Asp Leu Leu His Arg Pro Ser Asp Ala 
    210                 215                 220                 


Leu Ala Lys Ala Arg Leu Trp Leu His Pro Leu Pro Met Val Ser Ser 
225                 230                 235                 240 


Lys Glu Ser Gly Pro Gln Glu Val Ser Lys Gly Leu Gly Pro Phe Leu 
                245                 250                 255     


Gln Thr Ala Lys Pro Ala Arg Arg Gly Gln Thr Ser Ala Ser Ile Leu 
            260                 265                 270         


Pro Arg Val Val Gln Ala Gln Arg Gly Pro Gln Pro Pro Pro Gly Glu 
        275                 280                 285             


Ala Gly Ile Pro Gly His Pro Thr Pro Pro Ala Thr Leu Pro Ser Glu 
    290                 295                 300                 


Pro Val Glu Gly Val Gln Ala Ser Pro Trp Arg Pro Arg Pro Val Leu 
305                 310                 315                 320 


Pro Thr His Pro Ala Leu Thr Leu Pro Val Ser Ser Asp Ala Ser Ser 
                325                 330                 335     


Pro Ser Pro Pro Ala Pro Arg Pro Glu Arg Pro Glu Ser Leu Leu Val 
            340                 345                 350         


Ser Gly Pro Ser Val Thr Leu Thr Glu Gly Leu Gly Thr Val Arg Pro 
        355                 360                 365             


Glu Gln Asp Pro Ala Lys Ser Pro Gly Ser Pro Leu Leu Leu Arg Gly 
    370                 375                 380                 


Leu Ser Ser Gly Asp Val Ala Ala Pro Glu Pro Ile Met Gly Glu Pro 
385                 390                 395                 400 


Gly Gln Ala Ser Glu Glu Phe Gln Pro Leu Ala Arg Pro Trp Arg Ala 
                405                 410                 415     


Thr Leu Ala Ala Glu Glu Leu Val Ser His Arg Ser Pro Gly Glu Pro 
            420                 425                 430         


Gln Glu Thr Cys Ser Gly Thr Glu Val Glu Arg Pro Arg Gln Thr Gly 
        435                 440                 445             


Pro Gly Leu Pro Arg Glu Gly Ala Arg Gly His Met Asp Leu Ser Ser 
    450                 455                 460                 


Ser Glu Pro Ser Gln Asp Ile Glu Gly Pro Gly Leu Ser Ile Leu Pro 
465                 470                 475                 480 


Ala Arg Asp Ala Thr Phe Ser Thr Pro Ser Val Arg Gln Pro Asp Pro 
                485                 490                 495     


Ser Ala Trp Leu Ser Ser Gly Pro Glu Leu Thr Gly Met Pro Arg Val 
            500                 505                 510         


Arg Leu Ala Ala Pro Leu Ala Val Leu Pro Met Glu Pro Leu Pro Pro 
        515                 520                 525             


Glu Pro Val Arg Pro Ala Ala Leu Leu Thr Pro Glu Ala Ser Ser Val 
    530                 535                 540                 


Gly Gly Pro Asp Gln Ala Arg Tyr Leu Glu Ser Ala Pro Gly Trp Pro 
545                 550                 555                 560 


Val Gly Gln Glu Glu Trp Gly Val Ala His Thr Ser Ser Pro Pro Ser 
                565                 570                 575     


Thr Gln Thr Leu Ser Leu Trp Ala Pro Thr Gly Val Leu Leu Pro Ser 
            580                 585                 590         


Leu Val Glu Leu Glu Tyr Pro Phe Gln Ala Gly Arg Gly Ala Ser Leu 
        595                 600                 605             


Gln Gln Glu Leu Thr Glu Pro Thr Leu Ala Leu Ser Ala Glu Ser His 
    610                 615                 620                 


Arg Pro Pro Glu Leu Gln Asp Ser Val Glu Gly Leu Ser Glu Arg Pro 
625                 630                 635                 640 


Ser Arg 
        


<210>  1363
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf141__Homo_sapiens__XP_011539768

<400>  1363

Met Ala Glu Lys Ile Leu Glu Lys Leu Asp Val Leu Asp Lys Gln Ala 
1               5                   10                  15      


Glu Ile Ile Leu Ala Arg Arg Thr Lys Ile Asn Arg Leu Gln Ser Glu 
            20                  25                  30          


Gly Arg Lys Thr Thr Met Ala Ile Pro Leu Thr Phe Asp Phe Gln Leu 
        35                  40                  45              


Glu Phe Glu Glu Ala Leu Ala Thr Ser Ala Ser Lys Ala Ile Ser Lys 
    50                  55                  60                  


Ile Lys Glu Asp Lys Ser Cys Ser Ile Thr Lys Ser Lys Met His Val 
65                  70                  75                  80  


Ser Phe Lys Cys Glu Pro Glu Pro Arg Lys Ser Asn Phe Glu Lys Ser 
                85                  90                  95      


Asn Leu Arg Pro Phe Phe Ile Gln Thr Asn Val Lys Asn Lys Glu Ser 
            100                 105                 110         


Glu Ser Thr Glu Pro Val Glu Glu His Leu Lys Ser Arg Ser Ile Arg 
        115                 120                 125             


Pro Tyr Leu Tyr Leu Lys Asp Thr Thr Glu Met Glu Asn Ala Gly Pro 
    130                 135                 140                 


Leu Asn Val Leu Tyr Ser Gln His Arg Gln Ala Cys Arg Arg Ser Leu 
145                 150                 155                 160 


Gly Ser Thr Asp Phe Ser Pro Met Phe Asn Ile Gln Ser Asn Ala His 
                165                 170                 175     


Lys Lys Glu Lys Asp Ser Thr Leu Phe Thr Ala Gln Ile Glu Lys Lys 
            180                 185                 190         


Pro Arg Lys Pro Leu Asp Ser Val Gly Leu Leu Glu Gly Asp Arg Asn 
        195                 200                 205             


Lys Arg Lys Lys Ser Pro Gln Met Asn Asp Phe Asn Ile Lys Glu Asn 
    210                 215                 220                 


Lys Ser Val Arg Asn Tyr Gln Leu Ser Lys Tyr Arg Ser Val Arg Lys 
225                 230                 235                 240 


Lys Ser Leu Leu Pro Leu Cys Phe Glu Asp Glu Leu Lys Asn Pro His 
                245                 250                 255     


Ala Lys Ile Val Asn Val Ser Pro Thr Lys Thr Val Thr Ser His Met 
            260                 265                 270         


Glu Gln Lys Asp Thr Asn Pro Ile Ile Phe His Asp Thr Glu Tyr Val 
        275                 280                 285             


Arg Met Leu Leu Leu Thr Lys Asn Arg Phe Ser Ser His Pro Leu Glu 
    290                 295                 300                 


Asn Glu Asn Ile Tyr Pro His Lys Arg Thr Asn Phe Ile Leu Glu Arg 
305                 310                 315                 320 


Asn Cys Glu Ile Leu Lys Ser Ile Ile Gly Asn Gln Ser Ile Ser Leu 
                325                 330                 335     


Phe Lys Pro Gln Lys Thr Met Pro Thr Val Gln Arg Lys Asp Ile Gln 
            340                 345                 350         


Ile Pro Met Ser Phe Lys Ala Gly His Thr Thr Val Asp Asp Lys Leu 
        355                 360                 365             


Lys Lys Lys Thr Asn Lys Gln Thr Leu Glu Asn Arg Ser Trp Asn Thr 
    370                 375                 380                 


Leu Tyr Asn Phe Ser Gln Asn Phe Ser Ser Leu Thr Lys Gln Phe Val 
385                 390                 395                 400 


Gly Tyr Leu Asp Lys Ala Val Ile His Glu Met Ser Ala Gln Thr Gly 
                405                 410                 415     


Lys Phe Glu Arg Met Phe Ser Ala Gly Lys Pro Thr Ser Ile Pro Thr 
            420                 425                 430         


Ser Ser Ala Leu Pro Val Lys Cys Tyr Ser Lys Pro Phe Lys Tyr Ile 
        435                 440                 445             


Tyr Glu Leu Asn Asn Val Thr Pro Leu Asp Asn Leu Leu Asn Leu Ser 
    450                 455                 460                 


Asn Glu Ile Leu Asn Ala Ser 
465                 470     


<210>  1364
<211>  1494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf167__Homo_sapiens__XP_011539574

<400>  1364

Met Lys Arg Arg Leu Ser Gly Val Arg Thr Arg Gln Asn Lys Gly Asp 
1               5                   10                  15      


Gln Leu Gly Gly Gly Arg Ala His Leu Ile Lys Gln Thr Arg Pro Leu 
            20                  25                  30          


Thr Val Glu Trp Thr Lys Asp Thr Pro Val Pro Glu Pro Met Glu Leu 
        35                  40                  45              


Arg Ser Asp Ala Ser His Lys Glu Asn Val Ser Pro Lys Pro Ala Ala 
    50                  55                  60                  


Leu Pro Lys Pro Glu Gln Arg Arg Phe Arg Arg Ser Leu Gly Ile Gly 
65                  70                  75                  80  


Leu Ser Gly Arg His Asp Gln Trp Val Pro Gly Cys Gln Val Glu Arg 
                85                  90                  95      


Gly Gly Pro Ala Ala Thr Pro Ser Pro Gly Ala Val Leu Asp Gln Glu 
            100                 105                 110         


Pro Cys Arg Val Gln Thr Asn Leu Ala Ser Pro Gly Pro Arg Leu Gly 
        115                 120                 125             


Leu Ala Leu Lys Asp Thr Thr Gly Gln Leu Val Asn Ser Ser Phe Trp 
    130                 135                 140                 


Gln Gln Ser Asn Leu Gln Ser Leu Ala Arg Arg Arg Gln Gly Lys Ala 
145                 150                 155                 160 


Arg Glu Phe Ala Ile Gln Gln Ser Asn Leu Ser Ile Asn Glu Thr Ser 
                165                 170                 175     


Ser Pro His Leu Cys Pro Glu Pro Gly Gly Ser Ser Gly Pro His Lys 
            180                 185                 190         


Leu Pro Trp Gly Pro Leu Leu Ser Gln Glu Pro Leu Ala Arg Pro Ser 
        195                 200                 205             


Ser Cys Leu Arg Gln Ser Gly Leu Pro Ala Pro Gly Thr Pro Ser Gly 
    210                 215                 220                 


Asp Phe Arg Pro Thr Glu Ala Phe Ala Pro Leu Asp Gly His Thr Gln 
225                 230                 235                 240 


Pro Gly Leu Arg Ser Trp Gly Gly Leu Gly Ser Trp Arg Ser Arg Leu 
                245                 250                 255     


Val Gly Glu Pro Leu Thr Leu Glu Asp Leu Ala Val Pro Ser Gln Asn 
            260                 265                 270         


Gln Thr Gln Ala Pro Ser Arg Ala Ala Val His Gln Leu Leu Ala Ser 
        275                 280                 285             


Val His Cys Leu Ala Gln Glu Ala Ala Arg Leu Arg Cys Gln Ala Pro 
    290                 295                 300                 


Gln Glu Pro Pro Gly Ala Val Gln Gln Asp Leu Trp Thr Gly Gly Gly 
305                 310                 315                 320 


Gln Pro Phe Ser Ala His Pro Gln Pro Ser Gln Pro Val Leu Ala Ser 
                325                 330                 335     


Ser Asp Gly Arg Arg Arg Arg Leu Arg Gly His Arg Glu Thr Ala Ala 
            340                 345                 350         


Phe Leu Glu Thr Pro Ala Ser Leu Ser Asp Ser Trp Ala Gln Ser Lys 
        355                 360                 365             


Leu Met Ser Pro Glu Thr Thr Leu Gly Thr Arg Thr Lys Asp Ser Leu 
    370                 375                 380                 


Asn Pro Glu Gln Gly Leu Pro Pro Ala His Pro Leu Gly Ser Gly Asp 
385                 390                 395                 400 


Ser Cys Ser Pro Trp Ser Gln Asp Gly Arg Ala Gln Arg Gly Asp Pro 
                405                 410                 415     


Ser Leu Pro Arg Gly Val Gly Ser Arg Gly Thr Asp Pro Cys Ser Ser 
            420                 425                 430         


Ala Phe Ser Asn Thr Ala Trp Gly Val Ser Pro Lys Gln Lys Gly Glu 
        435                 440                 445             


Glu Gly Ala Pro Arg Glu Arg Val His Arg Glu Glu Glu Arg Thr Ala 
    450                 455                 460                 


Phe His Leu Ser Asp Thr Val Pro Ala Ser Ser Ala Ser Lys Asn Lys 
465                 470                 475                 480 


Ala Gln Asn Ile Thr Ala Pro Glu Ser Glu Ala Ile Cys Trp Gln Leu 
                485                 490                 495     


Leu Ser Arg Cys Phe Arg Ser Trp Arg His Leu Val Lys Arg Gln Arg 
            500                 505                 510         


Glu Pro Ala Ala Ala Ala Val Ala Leu Gly Arg Trp Gln Leu Leu Arg 
        515                 520                 525             


Lys Cys Leu Gln Ala Leu Trp Leu Arg Glu Ala Gln Leu Glu Ala Ala 
    530                 535                 540                 


Trp Gly Gln Tyr Thr Lys Val Leu Leu Val Arg Ser Phe Arg Glu Trp 
545                 550                 555                 560 


Arg Asn Leu Ala Leu Gln Gln Lys Gln Val Gln Pro His Met Gln Ala 
                565                 570                 575     


Gly Pro Gly Ser Pro Pro Ser Arg Arg Ala Gln Gly Lys Gly Leu Ser 
            580                 585                 590         


Leu Gly Arg Ser Thr Val Val Asp Pro Ala Gln Arg Ser Arg Leu Glu 
        595                 600                 605             


His Thr Ser Pro Gly Ser Leu Arg Glu Glu Glu Ile Ala Gln Arg Leu 
    610                 615                 620                 


Leu Ser His Pro Arg Gln Arg Thr Asp Ser Arg His Glu Arg Val Gln 
625                 630                 635                 640 


Ile Leu Gln Ala Leu Gln Leu Ala Val Phe Phe Leu Trp Cys Gln Gln 
                645                 650                 655     


Lys Lys Arg Ala Arg Gln Glu Arg Glu Thr Leu Arg Lys Ala Thr Arg 
            660                 665                 670         


Ala Thr Gln Arg Thr Gly Ser Phe Pro Gln Ala Trp His Ser Thr Ala 
        675                 680                 685             


Ala Gly Val Ala Trp Val Ala Pro Leu Ser Pro Gln His Gln Arg Ala 
    690                 695                 700                 


Trp Leu Cys Arg Cys Phe Gly Ala Trp Gln Gln Phe Val Gln Arg Gly 
705                 710                 715                 720 


Ser Arg Tyr Arg Asp His Leu Ala Asp Arg Arg Thr Gly Thr Leu Arg 
                725                 730                 735     


Lys Cys Leu Glu Gln Trp Val Arg Met Lys Gln Leu Arg Glu Ser Asp 
            740                 745                 750         


Gly Ala Lys Val Thr Gln Leu Ser Leu Cys Arg Gln Lys Ala Gly Arg 
        755                 760                 765             


Glu Ala Val Tyr Thr Ala Gly Pro Gly Ala Cys Gly Leu Gly Ala Val 
    770                 775                 780                 


Gly Gln Ala Gln Gly Gln Gln Glu Gln Gly Arg Gly Ser Leu Gln Asp 
785                 790                 795                 800 


Ala Cys Trp Thr Leu Ala Leu Cys Trp Ala Leu Leu Leu Trp Lys Met 
                805                 810                 815     


Arg Leu Phe Gln Arg Gln Trp Ala Asn Ser Phe Phe Gln Gly Leu Gln 
            820                 825                 830         


Gln Arg Met Leu Gln Arg Ser Leu Arg Trp Trp His Leu Arg Ala Leu 
        835                 840                 845             


Gly Pro Asp Ala Thr Ser Ser Cys Thr Lys Thr Pro Ser Ala Leu Glu 
    850                 855                 860                 


Pro Leu Ser Ser Ser Thr Leu Gln Asp Ser Leu Glu Lys Val Pro Arg 
865                 870                 875                 880 


Ala Pro Thr Leu Pro Asp Thr Leu Gln Gly Ser Leu Leu Trp Ala Ala 
                885                 890                 895     


Gly Gln Arg Gln Gln Gly Gln Cys Leu Leu Leu Trp Gln Ala Arg Ala 
            900                 905                 910         


Gln Gln Phe Gln Gly Thr Ala Arg Trp Tyr Gln His Thr Arg Gln Arg 
        915                 920                 925             


Arg Ile Phe Leu Ser Trp Ser Arg Trp Ala Thr Ala Gln Trp Ala Trp 
    930                 935                 940                 


Arg Glu Leu Ala Ser His Arg Ala Trp Asp Arg Thr Cys Arg Ala Val 
945                 950                 955                 960 


Leu Gly Leu Trp Arg Gln Arg Leu Leu Gln Ser Arg Leu Val Glu Trp 
                965                 970                 975     


Trp Ala Gln Glu Arg Gly Trp Arg Leu Ala Arg Asp Ala Leu Cys His 
            980                 985                 990         


Trp His Ser Cys Trp Gln Gly Gln  Gln Phe Leu His Glu  Lys Cys Gln 
        995                 1000                 1005             


Thr Trp  Val Gln Val His Leu  Gln Gly Leu Gln Lys  Val Val Phe 
    1010                 1015                 1020             


Arg Ser  Trp Gln Gln Ala Ala  Ala His Gln Arg Cys  Thr Val Thr 
    1025                 1030                 1035             


Arg Pro  Glu Gln Leu Leu Leu  Gln Ser Tyr Phe Gln  Ala Trp Cys 
    1040                 1045                 1050             


Glu Val  Val Arg Asp Thr Gly  Val Leu Arg Ala Gln  His Gln Ala 
    1055                 1060                 1065             


Phe Gln  Asp Gly Leu Arg Arg  Arg Ala Leu Gly Ala  Val Phe Ala 
    1070                 1075                 1080             


Thr Trp  Arg Glu Ala Gln Glu  Val Ala Ala Gly Ala  Gln Glu Gln 
    1085                 1090                 1095             


Arg Val  Ala Gln Ala Ser Leu  Ala Arg Trp Arg Ser  Cys Gly Gln 
    1100                 1105                 1110             


Gln Gly  Gln Glu Asp Gly Gln  Gln Lys Lys Ala Arg  Ala Pro Gln 
    1115                 1120                 1125             


Ala Phe  Pro Ala Trp Pro Val  Ala Pro Gly Met His  His Glu Ala 
    1130                 1135                 1140             


Gln Gln  Gln Ala Gly Glu Ser  Ala Gly Ala Gln Ala  Ala Gln Cys 
    1145                 1150                 1155             


Trp Thr  Trp Cys Trp Ala Leu  Trp Val His Glu Ser  Cys Arg Gly 
    1160                 1165                 1170             


Gln Val  Ser Arg Ala His Ala  Ser Trp Lys Pro Arg  Ala Trp Val 
    1175                 1180                 1185             


Leu Glu  Ala Ser Val Gln Ser  Ala Val Arg Gly Gly  Val Gln Arg 
    1190                 1195                 1200             


Ala Ile  Leu Thr Gln Leu Arg  Pro Ala Glu Leu Arg  Arg Phe Leu 
    1205                 1210                 1215             


Arg Thr  Val Gln Leu Arg Val  Arg Leu Gly Leu Pro  Gly Ala Gly 
    1220                 1225                 1230             


Lys Thr  Arg Ser Cys Trp Thr  Gln Ala Thr Glu Leu  Val Pro Pro 
    1235                 1240                 1245             


Ala Pro  Ser Leu Gln Cys Ser  Leu Gly Gly Arg Arg  Lys Pro Arg 
    1250                 1255                 1260             


Gly Thr  Ala Trp Ala Gln Arg  Cys Arg Glu His Ser  Leu Cys Pro 
    1265                 1270                 1275             


Ala Phe  Gln Leu Trp Pro Gln  Trp Pro Gly Gln Ser  Ser Trp Val 
    1280                 1285                 1290             


Pro Gly  Leu Pro Leu Trp Thr  Arg Asp Gln Gly Pro  Arg Ala His 
    1295                 1300                 1305             


Ser Ser  Pro Glu Pro Arg Ala  Cys Lys Ala Gln Ser  Lys Ala His 
    1310                 1315                 1320             


Lys Arg  Arg Leu Arg Ala Arg  Ser Cys Arg Ile Leu  Glu Lys Gln 
    1325                 1330                 1335             


Ala Gln  Ala His Gly Ser Ala  Leu Leu Leu Ala Leu  Lys Gly His 
    1340                 1345                 1350             


Asp Ala  Leu Gly His Gln Glu  Glu Val Pro Ala Ala  Pro Val Pro 
    1355                 1360                 1365             


Arg Gly  Thr Ala Ser Arg Ala  Ala Gly Phe Pro Ala  Gly Gln Val 
    1370                 1375                 1380             


Pro Gly  Ser Gly Met Ala Ala  Leu Gly Gly Cys Pro  Arg Gly Arg 
    1385                 1390                 1395             


Ala Ala  Gly Ala Asp Pro Ala  Gln Gly Val Ala Pro  Glu Met Gly 
    1400                 1405                 1410             


Leu Ala  Asp Val Val Ala Ala  Asp Pro Ala Thr Ala  Ser Gly Ser 
    1415                 1420                 1425             


Ala Val  Thr Ala Ala Gly Arg  Trp Ala Phe Lys Lys  Trp His Gln 
    1430                 1435                 1440             


Arg Leu  Ala Ala Arg Ser Pro  Arg Arg Gly Ala Ala  Ser Ser Pro 
    1445                 1450                 1455             


Arg Pro  Trp Ser Lys Pro Gly  Pro Lys Gly Pro Glu  Ser Gly Gln 
    1460                 1465                 1470             


Glu Ala  Ala Arg Ala Pro Arg  Gly Trp Gly Leu Gly  Ala Glu His 
    1475                 1480                 1485             


Gly Ala  Gln Leu Gln Leu 
    1490                 


<210>  1365
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf204__Homo_sapiens__NP_001127705

<400>  1365

Met Gly Met Leu Ala Pro Gly Pro Leu Gln Gly Arg Arg Pro Arg Lys 
1               5                   10                  15      


Gly His Lys Gly Gln Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser 
            20                  25                  30          


Gly Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn 
        35                  40                  45              


Val Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly 
    50                  55                  60                  


Pro Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu 
65                  70                  75                  80  


Ala Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala 
                85                  90                  95      


Asp Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val Ser 
            100                 105                 110         


Ser Pro His Cys Glu Glu Pro Cys Ala His Ser Cys Ala His Pro Gly 
        115                 120                 125             


Leu Pro Pro His Leu Val His Lys Leu Pro Leu Ser Tyr Leu Gln Thr 
    130                 135                 140                 


Gln Asp Thr Asp Ala Ala Ser Arg Arg Ile Asn Ala Pro Leu Ala Ala 
145                 150                 155                 160 


Gly Trp Ser Trp Leu Arg Leu Trp Leu Val Thr Leu Ala Ser Gly Val 
                165                 170                 175     


Asp Phe Pro Gln Val Ser Ala Trp Met Arg Ala Leu Pro Ser Pro Asp 
            180                 185                 190         


Cys Pro Gly Leu Arg Thr Thr Gly Glu Gln Met Gln Lys Leu Leu Leu 
        195                 200                 205             


Lys Glu Asn Lys Val Lys Thr Arg Lys Ser Lys Arg Arg Ser Gly Glu 
    210                 215                 220                 


Gly Ser His Leu Thr Thr Ser Ile Leu Glu Gln 
225                 230                 235 


<210>  1366
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf226__Homo_sapiens__NP_001078844

<400>  1366

Met Phe Glu Asn Leu Asn Thr Ala Leu Thr Pro Lys Leu Gln Ala Ser 
1               5                   10                  15      


Arg Ser Phe Pro His Leu Ser Lys Pro Val Ala Pro Gly Ser Ala Pro 
            20                  25                  30          


Leu Gly Ser Gly Glu Pro Gly Gly Pro Gly Leu Trp Val Gly Ser Ser 
        35                  40                  45              


Gln His Leu Lys Asn Leu Gly Lys Ala Met Gly Ala Lys Val Asn Asp 
    50                  55                  60                  


Phe Leu Arg Arg Lys Glu Pro Ser Ser Leu Gly Ser Val Gly Val Thr 
65                  70                  75                  80  


Glu Ile Asn Lys Thr Ala Gly Ala Gln Leu Ala Ser Gly Thr Asp Ala 
                85                  90                  95      


Ala Pro Glu Ala Trp Leu Glu Asp Glu Arg Ser Val Leu Gln Glu Thr 
            100                 105                 110         


Phe Pro Arg Leu Asp Pro Pro Pro Pro Ile Thr Arg Lys Arg Thr Pro 
        115                 120                 125             


Arg Ala Leu Lys Thr Thr Gln Asp Met Leu Ile Ser Ser Gln Pro Val 
    130                 135                 140                 


Leu Ser Ser Leu Glu Tyr Gly Thr Glu Pro Ser Pro Gly Gln Ala Gln 
145                 150                 155                 160 


Asp Ser Ala Pro Thr Ala Gln Pro Asp Val Pro Ala Asp Ala Ser Gln 
                165                 170                 175     


Pro Glu Ala Thr Met Glu Arg Glu Glu Arg Gly Lys Val Leu Pro Asn 
            180                 185                 190         


Gly Glu Val Ser Leu Ser Val Pro Asp Leu Ile His Lys Asp Ser Gln 
        195                 200                 205             


Asp Glu Ser Lys Leu Lys Met Thr Glu Cys Arg Arg Ala Ser Ser Pro 
    210                 215                 220                 


Ser Leu Ile Glu Arg Asn Gly Phe Lys Leu Ser Leu Ser Pro Ile Ser 
225                 230                 235                 240 


Leu Ala Glu Ser Trp Glu Asp Gly Ser Pro Pro Pro Gln Ala Arg Thr 
                245                 250                 255     


Ser Ser Leu Asp Asn Glu Gly Pro His Pro Asp Leu Leu Ser Phe Glu 
            260                 265                 270         


<210>  1367
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf228__Homo_sapiens__XP_011539646

<400>  1367

Met Thr Ser Ile Lys Glu Gln Ala Ala Ile Ser Arg Leu Leu Ser Phe 
1               5                   10                  15      


Leu Gln Glu Trp Asp Asn Ala Gly Lys Val Ala Arg Ser His Ile Leu 
            20                  25                  30          


Asp Lys Phe Ile Glu Thr Asn Gln Gly Lys Thr Ala Pro Glu Leu Glu 
        35                  40                  45              


Gln Glu Phe Ser Gln Gly Ala Ser Leu Phe Leu Val Arg Leu Thr Thr 
    50                  55                  60                  


Ser Leu Arg Ile Thr Tyr Met Thr Asp Ser Cys Leu Glu Lys Leu Leu 
65                  70                  75                  80  


Arg Ser Ile Gly Ile Phe Leu Ser Ala Val Ser Ser Asn Arg Tyr Leu 
                85                  90                  95      


Ile Glu Phe Leu Glu Val Gly Gly Val Leu Thr Leu Leu Glu Ile Leu 
            100                 105                 110         


Gly Leu Glu Lys Ile Lys Glu Glu Ala Lys Lys Glu Ser Val Lys Leu 
        115                 120                 125             


Leu Gln Val Ile Ala Asn Ser Gly Arg Thr Tyr Lys Glu Leu Ile Cys 
    130                 135                 140                 


Glu Ser Tyr Gly Val Arg Ser Ile Ala Glu Phe Leu Ala Lys Ser Lys 
145                 150                 155                 160 


Ser Glu Glu Thr Gln Glu Glu Val Gln Val Leu Leu Asp Ser Leu Val 
                165                 170                 175     


His Gly Asn Pro Lys Tyr Gln Asn Gln Val Tyr Lys Gly Leu Ile Ala 
            180                 185                 190         


Leu Leu Pro Cys Glu Ser Pro Lys Ala Gln Gln Leu Ser Leu Gln Thr 
        195                 200                 205             


Leu Arg Thr Ala Gln Pro Ile Ile Gly Thr Thr His Pro Ser Ile Val 
    210                 215                 220                 


Asp Cys Val Leu Lys Val Leu Gly Thr Met His Leu Glu Val Gln Tyr 
225                 230                 235                 240 


Glu Ala Ile Glu Leu Ile Lys Asp Leu Val Gly Tyr Asp Val Arg Gln 
                245                 250                 255     


Ala Leu Leu Lys Gly Leu Val Ala Leu Leu Ile Pro Ser Val Lys Glu 
            260                 265                 270         


Ile Ser Lys Leu Gln Ala Lys Ile Leu Ser Asp Pro Ser Val Leu Gln 
        275                 280                 285             


Leu Thr Pro Ser Leu Pro Met Phe Leu Gln Gln Ala Ala Ala Ala Lys 
    290                 295                 300                 


Ala Ile Gly Val Leu Ala Arg Asn Asp Met Ser Ile Ala Glu Glu Leu 
305                 310                 315                 320 


Leu Tyr Leu Arg Val Val Arg Gly Leu Met Ala Ala Met Gly Asn Thr 
                325                 330                 335     


Asp His Ser Asn Ser Gln Arg Leu Ala Ser Leu Thr Leu Glu Cys Phe 
            340                 345                 350         


Val Gln Met Phe Pro Leu Val Ala Glu His Val Arg Lys Cys Met Gly 
        355                 360                 365             


Glu Glu Leu Tyr Gln Leu Phe Leu Ser Asn Ala Glu Asp Leu Tyr Met 
    370                 375                 380                 


Lys Ile Asp Ser Ile Gln Ala Asp Ile Leu Ala Ala Asn Thr Val Asn 
385                 390                 395                 400 


Val Thr Lys Ala Leu Cys Leu His Gly Ser Ser Tyr Ser Met Asn Thr 
                405                 410                 415     


Leu Tyr Gly Ser Arg Asp Ser Ala Gln Met Ala Tyr Leu Thr His Phe 
            420                 425                 430         


Glu Glu Asp Val Glu Ser Lys Glu 
        435                 440 


<210>  1368
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf27__Homo_sapiens__NP_001157717

<400>  1368

Met Gly Arg Thr Tyr Ile Val Glu Glu Thr Val Gly Gln Tyr Leu Ser 
1               5                   10                  15      


Asn Ile Asn Leu Gln Gly Lys Ala Phe Val Ser Gly Leu Leu Ile Gly 
            20                  25                  30          


Gln Cys Ser Ser Gln Lys Asp Tyr Val Ile Leu Ala Thr Arg Thr Pro 
        35                  40                  45              


Pro Lys Glu Glu Gln Ser Glu Asn Leu Lys His Pro Lys Ala Lys Leu 
    50                  55                  60                  


Asp Asn Leu Asp Glu Glu Trp Ala Thr Glu His Ala Cys Gln Val Ser 
65                  70                  75                  80  


Arg Met Leu Pro Gly Gly Leu Leu Val Leu Gly Val Phe Ile Ile Thr 
                85                  90                  95      


Thr Leu Glu Leu Ala Asn Asp Phe Gln Asn Ala Leu Arg Arg Leu Met 
            100                 105                 110         


Phe Ala Val Glu Lys Ser Ile Asn Arg Lys Arg Leu Trp Asn Phe Thr 
        115                 120                 125             


Glu Glu Glu Val Ser Glu Arg Val Thr Leu His Ile Cys Ala Ser Thr 
    130                 135                 140                 


Lys Lys Ile Phe Cys Arg Thr Tyr Asp Ile His Asp Pro Lys Ser Ser 
145                 150                 155                 160 


Ala Arg Pro Ala Asp Trp Lys Tyr Gln Ser Gly Leu Ser Ser Ser Trp 
                165                 170                 175     


Leu Ser Leu Glu Cys Thr Val His Ile Asn Ile His Ile Pro Leu Ser 
            180                 185                 190         


Ala Thr Ser Val Ser Tyr Thr Leu Glu Lys Asn Thr Lys Asn Gly Leu 
        195                 200                 205             


Thr Arg Trp Ala Lys Glu Ile Glu Asn Gly Val Tyr Leu Ile Asn Gly 
    210                 215                 220                 


Gln Val Lys Asp Glu Asp Cys Asp Leu Leu Glu Gly Gln Leu Leu Asn 
225                 230                 235                 240 


Ser Asp His Arg Ser Thr Ala Thr Val Gln Ile Cys Ser Gly Ser Val 
                245                 250                 255     


Asn Leu Lys Gly Ala Val Lys Cys Arg Ala Tyr Ile His Ser Ser Lys 
            260                 265                 270         


Pro Lys Val Lys Asp Ala Val Gln Ala Val Lys Arg Asp Ile Leu Asn 
        275                 280                 285             


Thr Val Ala Asp Arg Cys Glu Met Leu Phe Glu Asp Leu Leu Leu Asn 
    290                 295                 300                 


Glu Ile Pro Glu Lys Lys Asp Ser Glu Lys Glu Phe His Val Leu Pro 
305                 310                 315                 320 


Tyr Arg Val Phe Val Pro Leu Pro Gly Ser Thr Val Met Leu Cys Asp 
                325                 330                 335     


Tyr Lys Phe Asp Asp Glu Ser Ala Glu Glu Ile Arg Asp His Phe Met 
            340                 345                 350         


Glu Met Leu Asp His Thr Ile Gln Ile Glu Asp Leu Glu Ile Ala Glu 
        355                 360                 365             


Glu Thr Asn Thr Ala Cys Met Ser Ser Ser Met Asn Ser Gln Ala Ser 
    370                 375                 380                 


Leu Asp Asn Thr Asp Asp Glu Gln Pro Lys Gln Pro Ile Lys Thr Thr 
385                 390                 395                 400 


Met Leu Leu Lys Ile Gln Gln Asn Ile Gly Val Ile Ala Ala Phe Thr 
                405                 410                 415     


Val Ala Val Leu Ala Ala Gly Ile Ser Phe His Tyr Phe Ser Asp 
            420                 425                 430     


<210>  1369
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf61__Homo_sapiens__NP_001307383

<400>  1369

Met Gly Thr Leu Gly Ser Ile Phe Ser Pro Gly Ala Gly Gly Phe Cys 
1               5                   10                  15      


Thr Thr Leu Pro Pro Ser Phe Leu Arg Val Asp Asp Arg Ala Thr Ser 
            20                  25                  30          


Ser Thr Thr Asp Ser Ser Arg Ala Pro Ser Ser Pro Arg Pro Pro Gly 
        35                  40                  45              


Ser Thr Ser His Cys Gly Ile Ser Thr Arg Cys Thr Glu Arg Cys Leu 
    50                  55                  60                  


Cys Val Leu Pro Leu Arg Thr Ser Gln Val Pro Asp Val Met Ala Pro 
65                  70                  75                  80  


Gln His Asp Gln Glu Pro Lys Arg Arg Met Tyr Phe Ile Trp Leu Gly 
                85                  90                  95      


Trp Ile Pro Ser Asp Lys Pro Ser Gln Leu Thr Glu Arg 
            100                 105                 


<210>  1370
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1orf86__Homo_sapiens__XP_011539224

<400>  1370

Met Glu Ala Ala Arg Arg Pro Arg Leu Gly Leu Ser Arg Arg Arg Pro 
1               5                   10                  15      


Arg Pro Ala Gly Gly Pro Ser Gly Gly Arg Pro Trp Phe Leu Leu Gly 
            20                  25                  30          


Gly Asp Glu Arg Glu Arg Leu Trp Ala Glu Leu Leu Arg Thr Val Ser 
        35                  40                  45              


Pro Glu Leu Ile Leu Asp His Glu Val Pro Ser Leu Pro Ala Phe Pro 
    50                  55                  60                  


Gly Gln Glu Pro Arg Cys Gly Pro Glu Pro Thr Glu Val Phe Thr Val 
65                  70                  75                  80  


Gly Pro Lys Thr Phe Ser Trp Thr Pro Phe Pro Pro Asp Leu Trp Gly 
                85                  90                  95      


Pro Gly Arg Ser Tyr Arg Leu Leu His Gly Ala Gly Gly His Leu Glu 
            100                 105                 110         


Ser Pro Ala Arg Ser Leu Pro Gln Arg Pro Ala Pro Asp Pro Cys Arg 
        115                 120                 125             


Ala Pro Arg Val Glu Gln Gln Pro Ser Val Glu Gly Ala Ala Ala Leu 
    130                 135                 140                 


Arg Ser Cys Pro Met Cys Gln Lys Glu Phe Ala Pro Arg Ser Lys Asn 
145                 150                 155                 160 


Ser Ser Gly Met Arg Arg His Arg Ser Pro Lys Leu Ala Ala Asn Asn 
                165                 170                 175     


Asn Asn Asn Lys Arg Lys Gly Arg Ala Arg Trp Leu Thr Pro Val Ile 
            180                 185                 190         


Pro Ala Leu 
        195 


<210>  1371
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QB__Homo_sapiens__XP_011540361

<400>  1371

Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr 
            20                  25                  30          


Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly 
        35                  40                  45              


Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu 
    50                  55                  60                  


Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro 
65                  70                  75                  80  


Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly 
                85                  90                  95      


Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu 
            100                 105                 110         


Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg 
        115                 120                 125             


Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His 
    130                 135                 140                 


Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe 
145                 150                 155                 160 


Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser 
                165                 170                 175     


Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250             


<210>  1372
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QBP__Homo_sapiens__NP_001203

<400>  1372

Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val 
1               5                   10                  15      


Ala Gly Leu Arg Ala Ala Ala Pro Ala Ser Pro Phe Arg Gln Leu Leu 
            20                  25                  30          


Gln Pro Ala Pro Arg Leu Cys Thr Arg Pro Phe Gly Leu Leu Ser Val 
        35                  40                  45              


Arg Ala Gly Ser Glu Arg Arg Pro Gly Leu Leu Arg Pro Arg Gly Pro 
    50                  55                  60                  


Cys Ala Cys Gly Cys Gly Cys Gly Ser Leu His Thr Asp Gly Asp Lys 
65                  70                  75                  80  


Ala Phe Val Asp Phe Leu Ser Asp Glu Ile Lys Glu Glu Arg Lys Ile 
                85                  90                  95      


Gln Lys His Lys Thr Leu Pro Lys Met Ser Gly Gly Trp Glu Leu Glu 
            100                 105                 110         


Leu Asn Gly Thr Glu Ala Lys Leu Val Arg Lys Val Ala Gly Glu Lys 
        115                 120                 125             


Ile Thr Val Thr Phe Asn Ile Asn Asn Ser Ile Pro Pro Thr Phe Asp 
    130                 135                 140                 


Gly Glu Glu Glu Pro Ser Gln Gly Gln Lys Val Glu Glu Gln Glu Pro 
145                 150                 155                 160 


Glu Leu Thr Ser Thr Pro Asn Phe Val Val Glu Val Ile Lys Asn Asp 
                165                 170                 175     


Asp Gly Lys Lys Ala Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu 
            180                 185                 190         


Val Gly Gln Glu Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Arg Glu 
        195                 200                 205             


Val Ser Phe Gln Ser Thr Gly Glu Ser Glu Trp Lys Asp Thr Asn Tyr 
    210                 215                 220                 


Thr Leu Asn Thr Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met 
225                 230                 235                 240 


Asp Phe Leu Ala Asp Arg Gly Val Asp Asn Thr Phe Ala Asp Glu Leu 
                245                 250                 255     


Val Glu Leu Ser Thr Ala Leu Glu His Gln Glu Tyr Ile Thr Phe Leu 
            260                 265                 270         


Glu Asp Leu Lys Ser Phe Val Lys Ser Gln 
        275                 280         


<210>  1373
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QL1__Homo_sapiens__NP_006679

<400>  1373

Met Leu Leu Val Leu Val Val Leu Ile Pro Val Leu Val Ser Ser Gly 
1               5                   10                  15      


Gly Pro Glu Gly His Tyr Glu Met Leu Gly Thr Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro Tyr Pro Ala Arg Gly Pro Gly Ala Gly Ala Arg Thr Asp Gly 
        35                  40                  45              


Gly Asp Ala Leu Ser Glu Gln Ser Gly Ala Pro Pro Pro Ser Thr Leu 
    50                  55                  60                  


Val Gln Gly Pro Gln Gly Lys Pro Gly Arg Thr Gly Lys Pro Gly Pro 
65                  70                  75                  80  


Pro Gly Pro Pro Gly Asp Pro Gly Pro Pro Gly Pro Val Gly Pro Pro 
                85                  90                  95      


Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Pro Gly Leu Pro Gly 
            100                 105                 110         


Ala Gly Gly Ser Gly Ala Ile Ser Thr Ala Thr Tyr Thr Thr Val Pro 
        115                 120                 125             


Arg Val Ala Phe Tyr Ala Gly Leu Lys Asn Pro His Glu Gly Tyr Glu 
    130                 135                 140                 


Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn Asn Tyr Asp 
145                 150                 155                 160 


Ala Ala Ser Gly Lys Phe Thr Cys Asn Ile Pro Gly Thr Tyr Phe Phe 
                165                 170                 175     


Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala 
            180                 185                 190         


Asp Leu Cys Lys Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp 
        195                 200                 205             


Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Ile Leu His Leu 
    210                 215                 220                 


Asp Ala Gly Asp Glu Val Phe Ile Lys Leu Asp Gly Gly Lys Ala His 
225                 230                 235                 240 


Gly Gly Asn Ser Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr 
                245                 250                 255     


Ser Asp 
        


<210>  1374
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QL3__Homo_sapiens__NP_001010908

<400>  1374

Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Val Ser Ser Ala 
1               5                   10                  15      


Gly Thr Ser Ala His Tyr Glu Met Leu Gly Thr Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala Thr Pro Asp 
        35                  40                  45              


Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly Pro Lys Gly 
    50                  55                  60                  


Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu 
65                  70                  75                  80  


Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro 
                85                  90                  95      


Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu Asn Ala 
            100                 105                 110         


Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Val Pro Lys Ile Ala 
        115                 120                 125             


Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu Val Leu Lys 
    130                 135                 140                 


Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr 
145                 150                 155                 160 


Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr Tyr His 
                165                 170                 175     


Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys 
            180                 185                 190         


Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln 
        195                 200                 205             


Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly 
    210                 215                 220                 


Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His Gly Gly Asn 
225                 230                 235                 240 


Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Ala Asp 
                245                 250                 255 


<210>  1375
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QTNF1__Homo_sapiens__NP_112230

<400>  1375

Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210>  1376
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QTNF3__Homo_sapiens__NP_112207

<400>  1376

Met Leu Trp Arg Gln Leu Ile Tyr Trp Gln Leu Leu Ala Leu Phe Phe 
1               5                   10                  15      


Leu Pro Phe Cys Leu Cys Gln Asp Glu Tyr Met Glu Ser Pro Gln Thr 
            20                  25                  30          


Gly Gly Leu Pro Pro Asp Cys Ser Lys Cys Cys His Gly Asp Tyr Ser 
        35                  40                  45              


Phe Arg Gly Tyr Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ile 
    50                  55                  60                  


Pro Gly Asn His Gly Asn Asn Gly Asn Asn Gly Ala Thr Gly His Glu 
65                  70                  75                  80  


Gly Ala Lys Gly Glu Lys Gly Asp Lys Gly Asp Leu Gly Pro Arg Gly 
                85                  90                  95      


Glu Arg Gly Gln His Gly Pro Lys Gly Glu Lys Gly Tyr Pro Gly Ile 
            100                 105                 110         


Pro Pro Glu Leu Gln Ile Ala Phe Met Ala Ser Leu Ala Thr His Phe 
        115                 120                 125             


Ser Asn Gln Asn Ser Gly Ile Ile Phe Ser Ser Val Glu Thr Asn Ile 
    130                 135                 140                 


Gly Asn Phe Phe Asp Val Met Thr Gly Arg Phe Gly Ala Pro Val Ser 
145                 150                 155                 160 


Gly Val Tyr Phe Phe Thr Phe Ser Met Met Lys His Glu Asp Val Glu 
                165                 170                 175     


Glu Val Tyr Val Tyr Leu Met His Asn Gly Asn Thr Val Phe Ser Met 
            180                 185                 190         


Tyr Ser Tyr Glu Met Lys Gly Lys Ser Asp Thr Ser Ser Asn His Ala 
        195                 200                 205             


Val Leu Lys Leu Ala Lys Gly Asp Glu Val Trp Leu Arg Met Gly Asn 
    210                 215                 220                 


Gly Ala Leu His Gly Asp His Gln Arg Phe Ser Thr Phe Ala Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Glu Thr Lys 
                245     


<210>  1377
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QTNF5__Homo_sapiens__NP_001265360

<400>  1377

Met Arg Pro Leu Leu Val Leu Leu Leu Leu Gly Leu Ala Ala Gly Ser 
1               5                   10                  15      


Pro Pro Leu Asp Asp Asn Lys Ile Pro Ser Leu Cys Pro Gly His Pro 
            20                  25                  30          


Gly Leu Pro Gly Thr Pro Gly His His Gly Ser Gln Gly Leu Pro Gly 
        35                  40                  45              


Arg Asp Gly Arg Asp Gly Arg Asp Gly Ala Pro Gly Ala Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Gly Gly Arg Pro Gly Leu Pro Gly Pro Arg Gly Asp Pro 
65                  70                  75                  80  


Gly Pro Arg Gly Glu Ala Gly Pro Ala Gly Pro Thr Gly Pro Ala Gly 
                85                  90                  95      


Glu Cys Ser Val Pro Pro Arg Ser Ala Phe Ser Ala Lys Arg Ser Glu 
            100                 105                 110         


Ser Arg Val Pro Pro Pro Ser Asp Ala Pro Leu Pro Phe Asp Arg Val 
        115                 120                 125             


Leu Val Asn Glu Gln Gly His Tyr Asp Ala Val Thr Gly Lys Phe Thr 
    130                 135                 140                 


Cys Gln Val Pro Gly Val Tyr Tyr Phe Ala Val His Ala Thr Val Tyr 
145                 150                 155                 160 


Arg Ala Ser Leu Gln Phe Asp Leu Val Lys Asn Gly Glu Ser Ile Ala 
                165                 170                 175     


Ser Phe Phe Gln Phe Phe Gly Gly Trp Pro Lys Pro Ala Ser Leu Ser 
            180                 185                 190         


Gly Gly Ala Met Val Arg Leu Glu Pro Glu Asp Gln Val Trp Val Gln 
        195                 200                 205             


Val Gly Val Gly Asp Tyr Ile Gly Ile Tyr Ala Ser Ile Lys Thr Asp 
    210                 215                 220                 


Ser Thr Phe Ser Gly Phe Leu Val Tyr Ser Asp Trp His Ser Ser Pro 
225                 230                 235                 240 


Val Phe Ala 
            


<210>  1378
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QTNF6__Homo_sapiens__NP_872292

<400>  1378

Met Gln Trp Leu Arg Val Arg Glu Ser Pro Gly Glu Ala Thr Gly His 
1               5                   10                  15      


Arg Val Thr Met Gly Thr Ala Ala Leu Gly Pro Val Trp Ala Ala Leu 
            20                  25                  30          


Leu Leu Phe Leu Leu Met Cys Glu Ile Pro Met Val Glu Leu Thr Phe 
        35                  40                  45              


Asp Arg Ala Val Ala Ser Gly Cys Gln Arg Cys Cys Asp Ser Glu Asp 
    50                  55                  60                  


Pro Leu Asp Pro Ala His Val Ser Ser Ala Ser Ser Ser Gly Arg Pro 
65                  70                  75                  80  


His Ala Leu Pro Glu Ile Arg Pro Tyr Ile Asn Ile Thr Ile Leu Lys 
                85                  90                  95      


Gly Asp Lys Gly Asp Pro Gly Pro Met Gly Leu Pro Gly Tyr Met Gly 
            100                 105                 110         


Arg Glu Gly Pro Gln Gly Glu Pro Gly Pro Gln Gly Ser Lys Gly Asp 
        115                 120                 125             


Lys Gly Glu Met Gly Ser Pro Gly Ala Pro Cys Gln Lys Arg Phe Phe 
    130                 135                 140                 


Ala Phe Ser Val Gly Arg Lys Thr Ala Leu His Ser Gly Glu Asp Phe 
145                 150                 155                 160 


Gln Thr Leu Leu Phe Glu Arg Val Phe Val Asn Leu Asp Gly Cys Phe 
                165                 170                 175     


Asp Met Ala Thr Gly Gln Phe Ala Ala Pro Leu Arg Gly Ile Tyr Phe 
            180                 185                 190         


Phe Ser Leu Asn Val His Ser Trp Asn Tyr Lys Glu Thr Tyr Val His 
        195                 200                 205             


Ile Met His Asn Gln Lys Glu Ala Val Ile Leu Tyr Ala Gln Pro Ser 
    210                 215                 220                 


Glu Arg Ser Ile Met Gln Ser Gln Ser Val Met Leu Asp Leu Ala Tyr 
225                 230                 235                 240 


Gly Asp Arg Val Trp Val Arg Leu Phe Lys Arg Gln Arg Glu Asn Ala 
                245                 250                 255     


Ile Tyr Ser Asn Asp Phe Asp Thr Tyr Ile Thr Phe Ser Gly His Leu 
            260                 265                 270         


Ile Lys Ala Glu Asp Asp 
        275             


<210>  1379
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QTNF7__Homo_sapiens__NP_001128642

<400>  1379

Met Ser Arg Gln Glu Pro Lys Met Phe Val Leu Leu Tyr Val Thr Ser 
1               5                   10                  15      


Phe Ala Ile Cys Ala Ser Gly Gln Pro Arg Gly Asn Gln Leu Lys Gly 
            20                  25                  30          


Glu Asn Tyr Ser Pro Arg Tyr Ile Cys Ser Ile Pro Gly Leu Pro Gly 
        35                  40                  45              


Pro Pro Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg 
    50                  55                  60                  


Ile Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu Lys 
65                  70                  75                  80  


Gly Glu Lys Gly Thr Ala Gly Leu Arg Gly Lys Thr Gly Pro Leu Gly 
                85                  90                  95      


Leu Ala Gly Glu Lys Gly Asp Gln Gly Glu Thr Gly Lys Lys Gly Pro 
            100                 105                 110         


Ile Gly Pro Glu Gly Glu Lys Gly Glu Val Gly Pro Ile Gly Pro Pro 
        115                 120                 125             


Gly Pro Lys Gly Asp Arg Gly Glu Gln Gly Asp Pro Gly Leu Pro Gly 
    130                 135                 140                 


Val Cys Arg Cys Gly Ser Ile Val Leu Lys Ser Ala Phe Ser Val Gly 
145                 150                 155                 160 


Ile Thr Thr Ser Tyr Pro Glu Glu Arg Leu Pro Ile Ile Phe Asn Lys 
                165                 170                 175     


Val Leu Phe Asn Glu Gly Glu His Tyr Asn Pro Ala Thr Gly Lys Phe 
            180                 185                 190         


Ile Cys Ala Phe Pro Gly Ile Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu 
        195                 200                 205             


Ala Asn Lys His Leu Ala Ile Gly Leu Val His Asn Gly Gln Tyr Arg 
    210                 215                 220                 


Ile Lys Thr Phe Asp Ala Asn Thr Gly Asn His Asp Val Ala Ser Gly 
225                 230                 235                 240 


Ser Thr Val Ile Tyr Leu Gln Pro Glu Asp Glu Val Trp Leu Glu Ile 
                245                 250                 255     


Phe Phe Thr Asp Gln Asn Gly Leu Phe Ser Asp Pro Gly Trp Ala Asp 
            260                 265                 270         


Ser Leu Phe Ser Gly Phe Leu Leu Tyr Val Asp Thr Asp Tyr Leu Asp 
        275                 280                 285             


Ser Ile Ser Glu Asp Asp Glu Leu 
    290                 295     


<210>  1380
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1QTNF9B-AS1__Homo_sapiens__NP_001014442

<400>  1380

Met Trp Ile Leu Ser Asn Leu Met Gly Thr Ser Glu Glu Gly Asn Leu 
1               5                   10                  15      


Leu Ser Thr Val Ser Pro Thr Val Lys Ala Leu Phe Gly Lys Thr Arg 
            20                  25                  30          


Val Ser Pro Ile Phe Pro Phe Ser Pro Arg Ser Pro Phe Gln Pro Leu 
        35                  40                  45              


Ile Pro Arg Thr Pro Gly Ser Pro Trp Gly Pro Val Gly Pro Ala Ser 
    50                  55                  60                  


Pro Leu Gly Pro Gly Phe Pro Ile Gly Pro Met Gly Pro Gly Lys Pro 
65                  70                  75                  80  


Val Gly Pro Lys Gly Pro Met Leu Pro Leu Gly Pro Ser Gly Pro Val 
                85                  90                  95      


Gly Pro Thr Ser Pro Leu Phe Pro Phe Cys Pro 
            100                 105         


<210>  1381
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1R__Homo_sapiens__NP_001724

<400>  1381

Met Trp Leu Leu Tyr Leu Leu Val Pro Ala Leu Phe Cys Arg Ala Gly 
1               5                   10                  15      


Gly Ser Ile Pro Ile Pro Gln Lys Leu Phe Gly Glu Val Thr Ser Pro 
            20                  25                  30          


Leu Phe Pro Lys Pro Tyr Pro Asn Asn Phe Glu Thr Thr Thr Val Ile 
        35                  40                  45              


Thr Val Pro Thr Gly Tyr Arg Val Lys Leu Val Phe Gln Gln Phe Asp 
    50                  55                  60                  


Leu Glu Pro Ser Glu Gly Cys Phe Tyr Asp Tyr Val Lys Ile Ser Ala 
65                  70                  75                  80  


Asp Lys Lys Ser Leu Gly Arg Phe Cys Gly Gln Leu Gly Ser Pro Leu 
                85                  90                  95      


Gly Asn Pro Pro Gly Lys Lys Glu Phe Met Ser Gln Gly Asn Lys Met 
            100                 105                 110         


Leu Leu Thr Phe His Thr Asp Phe Ser Asn Glu Glu Asn Gly Thr Ile 
        115                 120                 125             


Met Phe Tyr Lys Gly Phe Leu Ala Tyr Tyr Gln Ala Val Asp Leu Asp 
    130                 135                 140                 


Glu Cys Ala Ser Arg Ser Lys Leu Gly Glu Glu Asp Pro Gln Pro Gln 
145                 150                 155                 160 


Cys Gln His Leu Cys His Asn Tyr Val Gly Gly Tyr Phe Cys Ser Cys 
                165                 170                 175     


Arg Pro Gly Tyr Glu Leu Gln Glu Asp Arg His Ser Cys Gln Ala Glu 
            180                 185                 190         


Cys Ser Ser Glu Leu Tyr Thr Glu Ala Ser Gly Tyr Ile Ser Ser Leu 
        195                 200                 205             


Glu Tyr Pro Arg Ser Tyr Pro Pro Asp Leu Arg Cys Asn Tyr Ser Ile 
    210                 215                 220                 


Arg Val Glu Arg Gly Leu Thr Leu His Leu Lys Phe Leu Glu Pro Phe 
225                 230                 235                 240 


Asp Ile Asp Asp His Gln Gln Val His Cys Pro Tyr Asp Gln Leu Gln 
                245                 250                 255     


Ile Tyr Ala Asn Gly Lys Asn Ile Gly Glu Phe Cys Gly Lys Gln Arg 
            260                 265                 270         


Pro Pro Asp Leu Asp Thr Ser Ser Asn Ala Val Asp Leu Leu Phe Phe 
        275                 280                 285             


Thr Asp Glu Ser Gly Asp Ser Arg Gly Trp Lys Leu Arg Tyr Thr Thr 
    290                 295                 300                 


Glu Ile Ile Lys Cys Pro Gln Pro Lys Thr Leu Asp Glu Phe Thr Ile 
305                 310                 315                 320 


Ile Gln Asn Leu Gln Pro Gln Tyr Gln Phe Arg Asp Tyr Phe Ile Ala 
                325                 330                 335     


Thr Cys Lys Gln Gly Tyr Gln Leu Ile Glu Gly Asn Gln Val Leu His 
            340                 345                 350         


Ser Phe Thr Ala Val Cys Gln Asp Asp Gly Thr Trp His Arg Ala Met 
        355                 360                 365             


Pro Arg Cys Lys Ile Lys Asp Cys Gly Gln Pro Arg Asn Leu Pro Asn 
    370                 375                 380                 


Gly Asp Phe Arg Tyr Thr Thr Thr Met Gly Val Asn Thr Tyr Lys Ala 
385                 390                 395                 400 


Arg Ile Gln Tyr Tyr Cys His Glu Pro Tyr Tyr Lys Met Gln Thr Arg 
                405                 410                 415     


Ala Gly Ser Arg Glu Ser Glu Gln Gly Val Tyr Thr Cys Thr Ala Gln 
            420                 425                 430         


Gly Ile Trp Lys Asn Glu Gln Lys Gly Glu Lys Ile Pro Arg Cys Leu 
        435                 440                 445             


Pro Val Cys Gly Lys Pro Val Asn Pro Val Glu Gln Arg Gln Arg Ile 
    450                 455                 460                 


Ile Gly Gly Gln Lys Ala Lys Met Gly Asn Phe Pro Trp Gln Val Phe 
465                 470                 475                 480 


Thr Asn Ile His Gly Arg Gly Gly Gly Ala Leu Leu Gly Asp Arg Trp 
                485                 490                 495     


Ile Leu Thr Ala Ala His Thr Leu Tyr Pro Lys Glu His Glu Ala Gln 
            500                 505                 510         


Ser Asn Ala Ser Leu Asp Val Phe Leu Gly His Thr Asn Val Glu Glu 
        515                 520                 525             


Leu Met Lys Leu Gly Asn His Pro Ile Arg Arg Val Ser Val His Pro 
    530                 535                 540                 


Asp Tyr Arg Gln Asp Glu Ser Tyr Asn Phe Glu Gly Asp Ile Ala Leu 
545                 550                 555                 560 


Leu Glu Leu Glu Asn Ser Val Thr Leu Gly Pro Asn Leu Leu Pro Ile 
                565                 570                 575     


Cys Leu Pro Asp Asn Asp Thr Phe Tyr Asp Leu Gly Leu Met Gly Tyr 
            580                 585                 590         


Val Ser Gly Phe Gly Val Met Glu Glu Lys Ile Ala His Asp Leu Arg 
        595                 600                 605             


Phe Val Arg Leu Pro Val Ala Asn Pro Gln Ala Cys Glu Asn Trp Leu 
    610                 615                 620                 


Arg Gly Lys Asn Arg Met Asp Val Phe Ser Gln Asn Met Phe Cys Ala 
625                 630                 635                 640 


Gly His Pro Ser Leu Lys Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly 
                645                 650                 655     


Val Phe Ala Val Arg Asp Pro Asn Thr Asp Arg Trp Val Ala Thr Gly 
            660                 665                 670         


Ile Val Ser Trp Gly Ile Gly Cys Ser Arg Gly Tyr Gly Phe Tyr Thr 
        675                 680                 685             


Lys Val Leu Asn Tyr Val Asp Trp Ile Lys Lys Glu Met Glu Glu Glu 
    690                 695                 700                 


Asp 
705 


<210>  1382
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1RL__Homo_sapiens__NP_001284572

<400>  1382

Met Pro Gly Pro Arg Val Trp Gly Lys Tyr Leu Trp Arg Ser Pro His 
1               5                   10                  15      


Ser Lys Gly Cys Pro Gly Ala Met Trp Trp Leu Leu Leu Trp Gly Val 
            20                  25                  30          


Leu Gln Ala Cys Pro Thr Arg Gly Ser Val Leu Leu Ala Gln Glu Leu 
        35                  40                  45              


Pro Gln Gln Leu Thr Ser Pro Gly Tyr Pro Glu Pro Tyr Gly Lys Gly 
    50                  55                  60                  


Gln Glu Ser Ser Thr Asp Ile Lys Ala Pro Glu Gly Phe Ala Val Arg 
65                  70                  75                  80  


Leu Val Phe Gln Asp Phe Asp Leu Glu Pro Ser Gln Asp Cys Ala Gly 
                85                  90                  95      


Asp Ser Val Thr Ile Ser Phe Val Gly Ser Asp Pro Ser Gln Phe Cys 
            100                 105                 110         


Gly Gln Gln Gly Ser Pro Leu Gly Arg Pro Pro Gly Gln Arg Glu Phe 
        115                 120                 125             


Val Ser Ser Gly Arg Ser Leu Arg Leu Thr Phe Arg Thr Gln Pro Ser 
    130                 135                 140                 


Ser Glu Asn Lys Thr Ala His Leu His Lys Gly Phe Leu Ala Leu Tyr 
145                 150                 155                 160 


Gln Thr Val Gly Glu Cys Pro Ser Trp Gly Cys Arg Glu Gly Ala Ser 
                165                 170                 175     


Val Pro Ser His Asp Pro Gly Ile Phe Lys Pro 
            180                 185         


<210>  1383
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1S__Homo_sapiens__XP_005253817

<400>  1383

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala Glu 
1               5                   10                  15      


Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala Tyr 
            20                  25                  30          


Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly Tyr 
        35                  40                  45              


Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu Asn 
    50                  55                  60                  


Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu Gly 
65                  70                  75                  80  


Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile Val 
                85                  90                  95      


Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys Ser 
            100                 105                 110         


Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr Val 
        115                 120                 125             


Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys Ser 
    130                 135                 140                 


His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro Pro 
145                 150                 155                 160 


Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys Ser 
                165                 170                 175     


Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn Tyr 
            180                 185                 190         


Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg Leu 
        195                 200                 205             


Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe Asp 
    210                 215                 220                 


Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val Phe 
225                 230                 235                 240 


Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe Pro 
                245                 250                 255     


Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile Phe 
            260                 265                 270         


Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr His 
        275                 280                 285             


Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val Trp 
    290                 295                 300                 


Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile Thr 
305                 310                 315                 320 


Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr Ser 
                325                 330                 335     


Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys Leu 
            340                 345                 350         


Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn Gly 
        355                 360                 365             


Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg Tyr 
    370                 375                 380                 


Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly Glu 
385                 390                 395                 400 


Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly Pro 
                405                 410                 415     


Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro Phe 
            420                 425                 430         


Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys Asn 
        435                 440                 445             


Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala Leu 
    450                 455                 460                 


Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly Asn 
465                 470                 475                 480 


Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser Arg 
                485                 490                 495     


Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His Pro 
            500                 505                 510         


Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp Asn 
        515                 520                 525             


Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro Thr 
    530                 535                 540                 


Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu Met 
545                 550                 555                 560 


Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys Arg 
                565                 570                 575     


Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro Leu 
            580                 585                 590         


Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala Glu 
        595                 600                 605             


Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys Gly 
    610                 615                 620                 


Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln Asp 
625                 630                 635                 640 


Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp Gly 
                645                 650                 655     


Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr Val 
            660                 665                 670         


Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu Asp 
        675                 680                 685             


<210>  1384
<211>  1177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C20orf194__Homo_sapiens__NP_001009984

<400>  1384

Met Asp Val Tyr Pro Pro Arg Arg Gln Gly Leu Pro Arg Ala Arg Ser 
1               5                   10                  15      


Pro Gly Gly Ser Ser Arg Gly Ser Pro Ser Val Ser Cys Ser Arg Leu 
            20                  25                  30          


Arg Gln Val Gln Ser Ile Leu Thr Gln Ser Ser Lys Ser Arg Pro Asp 
        35                  40                  45              


Gly Ile Leu Cys Ile Leu Gly Ile Asp Ser Arg Tyr Asn Glu Gly Cys 
    50                  55                  60                  


Arg Glu Leu Ala Asn Tyr Leu Leu Phe Gly Leu Tyr Asn Gln Asn Thr 
65                  70                  75                  80  


Ser Asp Phe Glu Lys Thr Gly Phe Ser Glu Glu Val Leu Asp Asp Val 
                85                  90                  95      


Ile Ile Leu Ile Lys Ser Asp Ser Val His Leu Tyr Cys Asn Pro Val 
            100                 105                 110         


Asn Phe Arg Tyr Leu Leu Pro Tyr Val Ala His Trp Arg Asn Leu His 
        115                 120                 125             


Phe His Cys Met Thr Glu Asn Glu Tyr Glu Asp Glu Glu Ala Ala Glu 
    130                 135                 140                 


Glu Phe Lys Ile Thr Ser Phe Val Asp Met Val Arg Asp Cys Ser Arg 
145                 150                 155                 160 


Ile Gly Ile Pro Tyr Ser Ser Gln Gly His Leu Gln Ile Phe Asp Met 
                165                 170                 175     


Phe Val Val Glu Lys Trp Pro Ile Val Gln Ala Phe Ala Leu Glu Gly 
            180                 185                 190         


Ile Gly Gly Asp Gly Phe Phe Thr Met Lys Tyr Glu Leu Gln Asp Val 
        195                 200                 205             


Ser Leu Asn Leu Trp Asn Val Tyr Ser Lys Met Asp Pro Met Ser Leu 
    210                 215                 220                 


Glu Ser Leu Leu Ser Asp Asp Leu Val Ala Phe Glu His Gln Trp Thr 
225                 230                 235                 240 


Ser Phe Phe Ala Asn Phe Asp Thr Glu Ile Pro Phe Leu Leu Glu Leu 
                245                 250                 255     


Ser Glu Ser Gln Ala Gly Glu Pro Phe Arg Ser Tyr Phe Ser His Gly 
            260                 265                 270         


Met Ile Ser Ser His Ile Thr Glu Asn Ser Pro Asn Arg Gln Pro Phe 
        275                 280                 285             


Val Leu Phe Gly Asn His Ser Thr Arg Glu Asn Leu Asn Ala Gly Asn 
    290                 295                 300                 


Phe Asn Phe Pro Ser Glu Gly His Leu Val Arg Ser Thr Gly Pro Gly 
305                 310                 315                 320 


Gly Ser Phe Ala Lys His Met Val Ala Gln Cys Val Ser Pro Lys Gly 
                325                 330                 335     


Pro Leu Ala Cys Ser Arg Thr Tyr Phe Phe Gly Ala Thr His Val Pro 
            340                 345                 350         


Tyr Leu Gly Gly Asp Ser Lys Leu Pro Lys Lys Thr Glu Gln Ile Arg 
        355                 360                 365             


Leu Leu Ser Gln Ile Tyr Ala Ala Val Ile Glu Ala Val Leu Ala Gly 
    370                 375                 380                 


Ile Ala Cys Tyr Ala Lys Thr Ser Ser Leu Thr Lys Ala Lys Glu Val 
385                 390                 395                 400 


Ala Glu Gln Thr Leu Gly Ser Gly Leu Asp Ser Phe Glu Leu Ile Pro 
                405                 410                 415     


Phe Lys Ala Ala Leu Arg Ser Lys Met Thr Phe His Ile His Ala Val 
            420                 425                 430         


Asn Asn Gln Gly Arg Ile Val Pro Leu Asp Ser Glu Asp Ser Leu Ser 
        435                 440                 445             


Phe Val Lys Thr Ala Cys Met Ala Val Tyr Asp Ile Pro Asp Leu Leu 
    450                 455                 460                 


Gly Gly Asn Gly Cys Leu Gly Ser Val Val Phe Ser Glu Ser Phe Leu 
465                 470                 475                 480 


Thr Ser Gln Ile Leu Val Lys Glu Lys Asp Gly Thr Val Thr Thr Glu 
                485                 490                 495     


Thr Ser Ser Val Val Leu Thr Ala Ala Val Pro Arg Phe Cys Ser Trp 
            500                 505                 510         


Leu Val Glu Asp Asn Glu Val Lys Leu Ser Glu Lys Thr Gln Gln Ala 
        515                 520                 525             


Val Arg Gly Asp Glu Ser Phe Leu Gly Thr Tyr Leu Thr Gly Gly Glu 
    530                 535                 540                 


Gly Ala Tyr Leu Tyr Ser Ser Asn Leu Gln Ser Trp Pro Glu Glu Gly 
545                 550                 555                 560 


Asn Val His Phe Phe Ser Ser Gly Leu Leu Phe Ser His Cys Arg His 
                565                 570                 575     


Arg Ser Ile Ile Ile Ser Lys Asp His Met Asn Ser Ile Ser Phe Tyr 
            580                 585                 590         


Asp Gly Asp Ser Thr Ser Thr Val Ala Ala Leu Leu Ile Asp Phe Lys 
        595                 600                 605             


Ser Ser Leu Leu Pro His Leu Pro Val His Phe His Gly Ser Ser Asn 
    610                 615                 620                 


Phe Leu Met Ile Ala Leu Phe Pro Lys Ser Lys Ile Tyr Gln Ala Phe 
625                 630                 635                 640 


Tyr Ser Glu Val Phe Ser Leu Trp Lys Gln Gln Asp Asn Ser Gly Ile 
                645                 650                 655     


Ser Leu Lys Val Ile Gln Glu Asp Gly Leu Ser Val Glu Gln Lys Arg 
            660                 665                 670         


Leu His Ser Ser Ala Gln Lys Leu Phe Ser Ala Leu Ser Gln Pro Ala 
        675                 680                 685             


Gly Glu Lys Arg Ser Ser Leu Lys Leu Leu Ser Ala Lys Leu Pro Glu 
    690                 695                 700                 


Leu Asp Trp Phe Leu Gln His Phe Ala Ile Ser Ser Ile Ser Gln Glu 
705                 710                 715                 720 


Pro Val Met Arg Thr His Leu Pro Val Leu Leu Gln Gln Ala Glu Ile 
                725                 730                 735     


Asn Thr Thr His Arg Ile Glu Ser Asp Lys Val Ile Ile Ser Ile Val 
            740                 745                 750         


Thr Gly Leu Pro Gly Cys His Ala Ser Glu Leu Cys Ala Phe Leu Val 
        755                 760                 765             


Thr Leu His Lys Glu Cys Gly Arg Trp Met Val Tyr Arg Gln Ile Met 
    770                 775                 780                 


Asp Ser Ser Glu Cys Phe His Ala Ala His Phe Gln Arg Tyr Leu Ser 
785                 790                 795                 800 


Ser Ala Leu Glu Ala Gln Gln Asn Arg Ser Ala Arg Gln Ser Ala Tyr 
                805                 810                 815     


Ile Arg Lys Lys Thr Arg Leu Leu Val Val Leu Gln Gly Tyr Thr Asp 
            820                 825                 830         


Val Ile Asp Val Val Gln Ala Leu Gln Thr His Pro Asp Ser Asn Val 
        835                 840                 845             


Lys Ala Ser Phe Thr Ile Gly Ala Ile Thr Ala Cys Val Glu Pro Met 
    850                 855                 860                 


Ser Cys Tyr Met Glu His Arg Phe Leu Phe Pro Lys Cys Leu Asp Gln 
865                 870                 875                 880 


Cys Ser Gln Gly Leu Val Ser Asn Val Val Phe Thr Ser His Thr Thr 
                885                 890                 895     


Glu Gln Arg His Pro Leu Leu Val Gln Leu Gln Ser Leu Ile Arg Ala 
            900                 905                 910         


Ala Asn Pro Ala Ala Ala Phe Ile Leu Ala Glu Asn Gly Ile Val Thr 
        915                 920                 925             


Arg Asn Glu Asp Ile Glu Leu Ile Leu Ser Glu Asn Ser Phe Ser Ser 
    930                 935                 940                 


Pro Glu Met Leu Arg Ser Arg Tyr Leu Met Tyr Pro Gly Trp Tyr Glu 
945                 950                 955                 960 


Gly Lys Leu Asn Ala Gly Ser Val Tyr Pro Leu Met Val Gln Ile Cys 
                965                 970                 975     


Val Trp Phe Gly Arg Pro Leu Glu Lys Thr Arg Phe Val Ala Lys Cys 
            980                 985                 990         


Lys Ala Ile Gln Ser Ser Ile Lys  Pro Ser Pro Phe Ser  Gly Asn Ile 
        995                 1000                 1005             


Tyr His  Ile Leu Gly Lys Val  Lys Phe Ser Asp Ser  Glu Arg Thr 
    1010                 1015                 1020             


Met Glu  Val Cys Tyr Asn Thr  Leu Ala Asn Ser Leu  Ser Ile Met 
    1025                 1030                 1035             


Pro Val  Leu Glu Gly Pro Thr  Pro Pro Pro Asp Ser  Lys Ser Val 
    1040                 1045                 1050             


Ser Gln  Asp Ser Ser Gly Gln  Gln Glu Cys Tyr Leu  Val Phe Ile 
    1055                 1060                 1065             


Gly Cys  Ser Leu Lys Glu Asp  Ser Ile Lys Asp Trp  Leu Arg Gln 
    1070                 1075                 1080             


Ser Ala  Lys Gln Lys Pro Gln  Arg Lys Ala Leu Lys  Thr Arg Gly 
    1085                 1090                 1095             


Met Leu  Thr Gln Gln Glu Ile  Arg Ser Ile His Val  Lys Arg His 
    1100                 1105                 1110             


Leu Glu  Pro Leu Pro Ala Gly  Tyr Phe Tyr Asn Gly  Thr Gln Phe 
    1115                 1120                 1125             


Val Asn  Phe Phe Gly Asp Lys  Thr Asp Phe His Pro  Leu Met Asp 
    1130                 1135                 1140             


Gln Phe  Met Asn Asp Tyr Val  Glu Glu Ala Asn Arg  Glu Ile Glu 
    1145                 1150                 1155             


Lys Tyr  Asn Gln Glu Leu Glu  Gln Gln Glu Tyr His  Asp Leu Phe 
    1160                 1165                 1170             


Glu Leu  Lys Pro 
    1175         


<210>  1385
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C20orf196__Homo_sapiens__NP_001290406

<400>  1385

Met Ala Ala Arg Asp Ala Thr Ser Gly Ser Leu Ser Glu Glu Ser Ser 
1               5                   10                  15      


Ala Leu Asp Leu Pro Ser Ala Cys Asp Ile Arg Asp Tyr Val Leu Gln 
            20                  25                  30          


Gly Pro Ser Gln Glu Ala Asn Ser Glu Ala Phe Ser Ser Leu Glu Phe 
        35                  40                  45              


His Ser Phe Pro Tyr Ser Ser Asp Val Asp Pro Asp Thr Ser Asn Leu 
    50                  55                  60                  


Asn Ile Glu Gln Asn Asn Ser Trp Thr Ala Glu Asn Phe Trp Leu Asp 
65                  70                  75                  80  


Pro Ala Val Lys Gly Gln Ser Glu Lys Glu Glu Asp Asp Gly Leu Arg 
                85                  90                  95      


Lys Ser Leu Asp Arg Phe Tyr Glu Met Phe Gly His Pro Gln Pro Gly 
            100                 105                 110         


Ser Ala Asn Ser Leu Ser Ala Ser Val Cys Lys Cys Leu Ser Gln Lys 
        115                 120                 125             


Ile Thr Gln Leu Arg Gly Gln Glu Ser Gln Lys Tyr Ala Leu Arg Ser 
    130                 135                 140                 


Phe Gln Met Ala Arg Val Ile Phe Asn Arg Asp Gly Cys Ser Val Leu 
145                 150                 155                 160 


Gln Arg His Ser Arg Asp Thr His Phe Tyr Pro Leu Glu Glu Gly Ser 
                165                 170                 175     


Thr Ser Leu Asp Asp Glu Lys Pro Asn Pro Gly Leu Ser Lys Asp Ile 
            180                 185                 190         


Thr His Phe Leu Leu Gln Gln Asn Val Met Lys Asp Leu 
        195                 200                 205 


<210>  1386
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C20orf27__Homo_sapiens__NP_001034229

<400>  1386

Met Ala Ala Ala Asn Lys Gly Lys Cys Leu Pro Gly Val Val Gly Leu 
1               5                   10                  15      


Ala Gln Ala Leu Pro Val Gly Pro Gly Arg Arg Ala Ile Ala Ala Gly 
            20                  25                  30          


Asn Lys Pro Arg Val Arg Ser Ile Arg Phe Ala Ala Gly His Asp Ala 
        35                  40                  45              


Glu Gly Ser His Ser His Val His Phe Asp Glu Lys Leu His Asp Ser 
    50                  55                  60                  


Val Val Met Val Thr Gln Glu Ser Asp Ser Ser Phe Leu Val Lys Val 
65                  70                  75                  80  


Gly Phe Leu Lys Ile Leu His Arg Tyr Glu Ile Thr Phe Thr Leu Pro 
                85                  90                  95      


Pro Val His Arg Leu Ser Lys Asp Val Arg Glu Ala Pro Val Pro Ser 
            100                 105                 110         


Leu His Leu Lys Leu Leu Ser Val Val Pro Val Pro Glu Gly Tyr Ser 
        115                 120                 125             


Val Lys Cys Glu Tyr Ser Ala His Lys Glu Gly Val Leu Lys Glu Glu 
    130                 135                 140                 


Ile Leu Leu Ala Cys Glu Gly Gly Thr Gly Thr Cys Val Arg Val Thr 
145                 150                 155                 160 


Val Gln Ala Arg Val Met Asp Arg His His Gly Thr Pro Met Leu Leu 
                165                 170                 175     


Asp Gly Val Lys Cys Val Gly Ala Glu Leu Glu Tyr Asp Ser Glu His 
            180                 185                 190         


Ser Asp Trp His Gly Phe Asp 
        195                 


<210>  1387
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C20orf85__Homo_sapiens__NP_848551

<400>  1387

Met Ala Gln Lys Pro Leu Ser Thr Ala Ala Ala Glu Arg Met Asn Leu 
1               5                   10                  15      


Val Gly Gln Asp Glu Ile Trp Lys Tyr Arg Leu Lys Ala Glu Ser Glu 
            20                  25                  30          


Ala Arg Gln Asn Trp Pro Gln Asn Trp Gly Phe Leu Thr Thr Pro Phe 
        35                  40                  45              


Glu Glu Leu Ile Lys Cys Glu Glu Asp Leu Pro Thr Pro Lys Pro Lys 
    50                  55                  60                  


Ile Glu Leu Pro Glu Arg Phe Arg Ile Arg Pro Val Thr Pro Val Glu 
65                  70                  75                  80  


Lys Tyr Ile Lys Val Phe Pro Ser Pro Pro Val Pro Gln Thr Thr Gln 
                85                  90                  95      


Gly Phe Ile Gly Trp Arg Ser Ala Val Pro Gly Leu Asn Lys Cys Leu 
            100                 105                 110         


Glu Leu Asp Asp Ala Ile Arg Ser Cys Lys Gly Ala Phe Ala Arg Glu 
        115                 120                 125             


Leu Cys Trp Pro Lys Gln Gly Val His 
    130                 135         


<210>  1388
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C21orf2__Homo_sapiens__NP_001258369

<400>  1388

Met Lys Leu Thr Arg Lys Met Val Leu Thr Arg Ala Lys Ala Ser Glu 
1               5                   10                  15      


Leu His Ser Val Arg Lys Leu Asn Cys Trp Gly Ser Arg Leu Thr Asp 
            20                  25                  30          


Ile Ser Ile Cys Gln Glu Met Pro Ser Leu Glu Val Ile Thr Leu Ser 
        35                  40                  45              


Val Asn Ser Ile Ser Thr Leu Glu Pro Val Ser Arg Cys Gln Arg Leu 
    50                  55                  60                  


Ser Glu Leu Tyr Leu Arg Arg Asn Arg Ile Pro Ser Leu Ala Glu Leu 
65                  70                  75                  80  


Phe Tyr Leu Lys Gly Leu Pro Arg Leu Arg Val Leu Trp Leu Ala Glu 
                85                  90                  95      


Asn Pro Cys Cys Gly Thr Ser Pro His Arg Tyr Arg Met Thr Val Leu 
            100                 105                 110         


Arg Thr Leu Pro Arg Leu Gln Lys Leu Asp Asn Gln Ala Val Thr Glu 
        115                 120                 125             


Glu Glu Leu Ser Arg Ala Leu Ser Glu Gly Glu Glu Ile Thr Ala Ala 
    130                 135                 140                 


Pro Glu Arg Glu Gly Thr Gly His Gly Gly Pro Lys Leu Cys Cys Thr 
145                 150                 155                 160 


Leu Ser Ser Leu Ser Ser Ala Ala Glu Thr Gly Arg Asp Pro Leu Asp 
                165                 170                 175     


Ser Glu Glu Glu Ala Thr Gly Ala Gln Asp Glu Arg Gly Leu Lys Pro 
            180                 185                 190         


Pro Ser Arg Gly Gln Phe Pro Ser Leu Ser Ala Arg Asp Ala Ser Ser 
        195                 200                 205             


Ser His Arg Gly Arg Asn Val Leu Thr Ala Ile Leu Leu Leu Leu Arg 
    210                 215                 220                 


Glu Leu Asp Ala Glu Gly Leu Glu Ala Val Gln Gln Thr Val Gly Ser 
225                 230                 235                 240 


Arg Leu Gln Ala Leu Arg Gly Glu Glu Val Gln Glu His Ala Glu 
                245                 250                 255 


<210>  1389
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C21orf33__Homo_sapiens__NP_004640

<400>  1389

Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala 
            20                  25                  30          


Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val 
        35                  40                  45              


Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser 
    50                  55                  60                  


Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe 
65                  70                  75                  80  


Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln 
                85                  90                  95      


Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile 
            100                 105                 110         


Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His 
        115                 120                 125             


Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser 
    130                 135                 140                 


Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu 
145                 150                 155                 160 


Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys 
                165                 170                 175     


Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val 
            180                 185                 190         


Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly 
        195                 200                 205             


Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu 
    210                 215                 220                 


Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro 
225                 230                 235                 240 


Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly 
                245                 250                 255     


Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys 
            260                 265             


<210>  1390
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C21orf59__Homo_sapiens__NP_067077

<400>  1390

Met Val Leu Leu His Val Lys Arg Gly Asp Glu Ser Gln Phe Leu Leu 
1               5                   10                  15      


Gln Ala Pro Gly Ser Thr Glu Leu Glu Glu Leu Thr Val Gln Val Ala 
            20                  25                  30          


Arg Val Tyr Asn Gly Arg Leu Lys Val Gln Arg Leu Cys Ser Glu Met 
        35                  40                  45              


Glu Glu Leu Ala Glu His Gly Ile Phe Leu Pro Pro Asn Met Gln Gly 
    50                  55                  60                  


Leu Thr Asp Asp Gln Ile Glu Glu Leu Lys Leu Lys Asp Glu Trp Gly 
65                  70                  75                  80  


Glu Lys Cys Val Pro Ser Gly Gly Ala Val Phe Lys Lys Asp Asp Ile 
                85                  90                  95      


Gly Arg Arg Asn Gly Gln Ala Pro Asn Glu Lys Met Lys Gln Val Leu 
            100                 105                 110         


Lys Lys Thr Ile Glu Glu Ala Lys Ala Ile Ile Ser Lys Lys Gln Val 
        115                 120                 125             


Glu Ala Gly Val Cys Val Thr Met Glu Met Val Lys Asp Ala Leu Asp 
    130                 135                 140                 


Gln Leu Arg Gly Ala Val Met Ile Val Tyr Pro Met Gly Leu Pro Pro 
145                 150                 155                 160 


Tyr Asp Pro Ile Arg Met Glu Phe Glu Asn Lys Glu Asp Leu Ser Gly 
                165                 170                 175     


Thr Gln Ala Gly Leu Asn Val Ile Lys Glu Ala Glu Ala Gln Leu Trp 
            180                 185                 190         


Trp Ala Ala Lys Glu Leu Arg Arg Thr Lys Lys Leu Ser Asp Tyr Val 
        195                 200                 205             


Gly Lys Asn Glu Lys Thr Lys Ile Ile Ala Lys Ile Gln Gln Arg Gly 
    210                 215                 220                 


Gln Gly Ala Pro Ala Arg Glu Pro Ile Ile Ser Ser Glu Glu Gln Lys 
225                 230                 235                 240 


Gln Leu Met Leu Tyr Tyr His Arg Arg Gln Glu Glu Leu Lys Arg Leu 
                245                 250                 255     


Glu Glu Asn Asp Asp Asp Ala Tyr Leu Asn Ser Pro Trp Ala Asp Asn 
            260                 265                 270         


Thr Ala Leu Lys Arg His Phe His Gly Val Lys Asp Ile Lys Trp Arg 
        275                 280                 285             


Pro Arg 
    290 


<210>  1391
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C21orf62__Homo_sapiens__XP_011545334

<400>  1391

Met Ala Pro Pro Ser Arg His Cys Leu Leu Leu Ile Ser Thr Leu Gly 
1               5                   10                  15      


Val Phe Ala Leu Asn Cys Phe Thr Lys Gly Gln Lys Asn Ser Thr Leu 
            20                  25                  30          


Ile Phe Thr Arg Glu Asn Thr Ile Arg Asn Cys Ser Cys Ser Ala Asp 
        35                  40                  45              


Ile Arg Asp Cys Asp Tyr Ser Leu Ala Asn Leu Met Cys Asn Cys Lys 
    50                  55                  60                  


Thr Val Leu Pro Leu Ala Val Glu Arg Thr Ser Tyr Asn Gly His Leu 
65                  70                  75                  80  


Thr Ile Trp Phe Thr Asp Thr Ser Ala Leu Gly His Leu Leu Asn Phe 
                85                  90                  95      


Thr Leu Val Gln Asp Leu Lys Leu Ser Leu Cys Ser Thr Asn Thr Leu 
            100                 105                 110         


Pro Thr Glu Tyr Leu Ala Ile Cys Gly Leu Lys Arg Leu Arg Ile Asn 
        115                 120                 125             


Met Glu Ala Lys His Pro Phe Pro Glu Gln Ser Leu Leu Ile His Ser 
    130                 135                 140                 


Gly Gly Asp Ser Asp Ser Arg Glu Lys Pro Met Trp Leu His Lys Gly 
145                 150                 155                 160 


Trp Gln Pro Cys Met Tyr Ile Ser Phe Leu Asp Met Ala Leu Phe Asn 
                165                 170                 175     


Arg Asp Ser Ala Leu Lys Ser Tyr Ser Ile Glu Asn Val Thr Ser Ile 
            180                 185                 190         


Ala Asn Asn Phe Pro Asp Phe Ser Tyr Phe Arg Thr Phe Pro Met Pro 
        195                 200                 205             


Ser Asn Lys Ser Tyr Val Val Thr Phe Ile Tyr 
    210                 215                 


<210>  1392
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C21orf91__Homo_sapiens__NP_001093890

<400>  1392

Met Asn Glu Glu Glu Gln Phe Val Asn Ile Asp Leu Asn Asp Asp Asn 
1               5                   10                  15      


Ile Cys Ser Val Cys Lys Leu Gly Thr Asp Lys Glu Thr Leu Ser Phe 
            20                  25                  30          


Cys His Ile Cys Phe Glu Leu Asn Ile Glu Gly Val Pro Lys Ser Asp 
        35                  40                  45              


Leu Leu His Thr Lys Ser Leu Arg Gly His Lys Asp Cys Phe Glu Lys 
    50                  55                  60                  


Tyr His Leu Ile Ala Asn Gln Gly Cys Pro Arg Ser Lys Leu Ser Lys 
65                  70                  75                  80  


Ser Thr Tyr Glu Glu Val Lys Thr Ile Leu Ser Lys Lys Ile Asn Trp 
                85                  90                  95      


Ile Val Gln Tyr Ala Gln Asn Lys Asp Leu Asp Ser Asp Ser Glu Cys 
            100                 105                 110         


Ser Lys Asn Pro Gln His His Leu Phe Asn Phe Arg His Lys Pro Glu 
        115                 120                 125             


Glu Lys Leu Leu Pro Gln Phe Asp Ser Gln Val Pro Lys Tyr Ser Ala 
    130                 135                 140                 


Lys Trp Ile Asp Gly Ser Ala Gly Gly Ile Ser Asn Cys Thr Gln Arg 
145                 150                 155                 160 


Ile Leu Glu Gln Arg Glu Asn Thr Asp Phe Gly Leu Ser Met Leu Gln 
                165                 170                 175     


Asp Ser Gly Ala Thr Leu Cys Arg Asn Ser Val Leu Trp Pro His Ser 
            180                 185                 190         


His Asn Gln Ala Gln Lys Lys Glu Glu Thr Ile Ser Ser Pro Glu Ala 
        195                 200                 205             


Asn Val Gln Thr Gln His Pro His Tyr Ser Arg Glu Glu Leu Asn Ser 
    210                 215                 220                 


Met Thr Leu Gly Glu Val Glu Gln Leu Asn Ala Lys Leu Leu Gln Gln 
225                 230                 235                 240 


Ile Gln Glu Val Phe Glu Glu Leu Thr His Gln Val Gln Glu Lys Asp 
                245                 250                 255     


Ser Leu Ala Ser Gln Leu His Val Arg His Val Ala Ile Glu Gln Leu 
            260                 265                 270         


Leu Lys Asn Cys Ser Lys Leu Pro Cys Leu Gln Val Gly Arg Thr Gly 
        275                 280                 285             


Met Lys Ser His Leu Pro Ile Asn Asn 
    290                 295         


<210>  1393
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C22orf29__Homo_sapiens__NP_078903

<400>  1393

Met Pro Arg Gly Arg Cys Arg Gln Gln Gly Pro Arg Ile Pro Ile Trp 
1               5                   10                  15      


Ala Ala Ala Asn Tyr Ala Asn Ala His Pro Trp Gln Gln Met Asp Lys 
            20                  25                  30          


Ala Ser Pro Gly Val Ala Tyr Thr Pro Leu Val Asp Pro Trp Ile Glu 
        35                  40                  45              


Arg Pro Cys Cys Gly Asp Thr Val Cys Val Arg Thr Thr Met Glu Gln 
    50                  55                  60                  


Lys Ser Thr Ala Ser Gly Thr Cys Gly Gly Lys Pro Ala Glu Arg Gly 
65                  70                  75                  80  


Pro Leu Ala Gly His Met Pro Ser Ser Arg Pro His Arg Val Asp Phe 
                85                  90                  95      


Cys Trp Val Pro Gly Ser Asp Pro Gly Thr Phe Asp Gly Ser Pro Trp 
            100                 105                 110         


Leu Leu Asp Arg Phe Leu Ala Gln Leu Gly Asp Tyr Met Ser Phe His 
        115                 120                 125             


Phe Glu His Tyr Gln Asp Asn Ile Ser Arg Val Cys Glu Ile Leu Arg 
    130                 135                 140                 


Arg Leu Thr Gly Arg Ala Gln Ala Trp Ala Ala Pro Tyr Leu Asp Gly 
145                 150                 155                 160 


Asp Leu Pro Leu Pro Asp Asp Tyr Glu Leu Phe Cys Gln Asp Leu Lys 
                165                 170                 175     


Glu Val Val Gln Asp Pro Asn Ser Phe Ala Glu Tyr His Ala Val Val 
            180                 185                 190         


Thr Cys Pro Leu Pro Leu Ala Ser Ser Gln Leu Pro Val Ala Pro Gln 
        195                 200                 205             


Leu Pro Val Val Arg Gln Tyr Leu Ala Arg Phe Leu Glu Gly Leu Ala 
    210                 215                 220                 


Leu Asp Met Gly Thr Ala Pro Arg Ser Leu Pro Ala Ala Met Ala Thr 
225                 230                 235                 240 


Pro Ala Val Ser Gly Ser Asn Ser Val Ser Arg Ser Ala Leu Phe Glu 
                245                 250                 255     


Gln Gln Leu Thr Lys Glu Ser Thr Pro Gly Pro Lys Glu Pro Pro Val 
            260                 265                 270         


Leu Pro Ser Ser Thr Cys Ser Ser Lys Pro Gly Pro Val Glu Pro Ala 
        275                 280                 285             


Ser Ser Gln Pro Glu Glu Ala Ala Pro Thr Pro Val Pro Arg Leu Ser 
    290                 295                 300                 


Glu Ser Ala Asn Pro Pro Ala Gln Arg Pro Asp Pro Ala His Pro Gly 
305                 310                 315                 320 


Gly Pro Lys Pro Gln Lys Thr Glu Glu Glu Val Leu Glu Thr Glu Gly 
                325                 330                 335     


Asp Gln Glu Val Ser Leu Gly Thr Pro Gln Glu Val Val Glu Ala Pro 
            340                 345                 350         


Glu Thr Pro Gly Glu Pro Pro Leu Ser Pro Gly Phe 
        355                 360                 


<210>  1394
<211>  2353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2CD3__Homo_sapiens__NP_001273506

<400>  1394

Met Lys Gln Arg Lys Gly Gln Gly Ser Gly Gly Ser Arg Gly Arg Lys 
1               5                   10                  15      


Lys Arg Gly Leu Ser Asp Ile Ser Pro Ser Thr Ser Leu Pro Pro Leu 
            20                  25                  30          


Val Glu Gly Gln Leu Arg Cys Phe Leu Lys Leu Thr Val Asn Arg Val 
        35                  40                  45              


Ile Trp Lys Ile Ala Lys Pro Pro Thr Cys Val Leu Val Arg Val Arg 
    50                  55                  60                  


Trp Trp Gly Glu Thr Ser Asp Gly Thr Leu Phe Cys Pro Arg Asp Ala 
65                  70                  75                  80  


Leu Gln Thr Glu Pro Lys Ala Val Arg Thr Thr Thr Arg Tyr Ala Ile 
                85                  90                  95      


Arg Cys Gly Pro Lys Gln Phe Thr Ser Tyr Leu Thr Asp Met Ala Val 
            100                 105                 110         


Leu Val Leu Glu Val Ile Thr Lys Leu Asp Gly Leu Pro Ile Gly Arg 
        115                 120                 125             


Val Gln Ile Asn Gly Leu Ala Gln Leu Ser Pro Thr His Gln Ile Asn 
    130                 135                 140                 


Gly Phe Phe Thr Ile Val Ser Ser Thr Ser Lys Lys Leu Gly Glu Leu 
145                 150                 155                 160 


Gln Val Ser Leu Ala Leu Glu Pro Leu Ser Glu Thr Tyr Asp Ser Tyr 
                165                 170                 175     


His Pro Leu Pro Thr Thr Asp Met Thr Glu Asn Val Leu Leu Ser Lys 
            180                 185                 190         


Gln Gly Phe Arg Glu Asn Thr Glu Pro Ser Ser Thr Gln Phe Gln Val 
        195                 200                 205             


Pro Ser Arg Pro Arg Asp Ile His Thr Ile Lys Ile Asp Gly Lys Glu 
    210                 215                 220                 


Leu Ala Ala Asn Ser Ser Arg Ser Thr Thr Pro Arg Gly Lys Asp His 
225                 230                 235                 240 


Val Cys Phe Ala Glu Asn Pro Asp Thr Ile Lys Asp Ser Ser Phe Gly 
                245                 250                 255     


Leu Gln His Ser Leu Asn Ser Gly Gln Ser Leu Glu Ser Val Thr Leu 
            260                 265                 270         


Lys Gly Arg Ala Pro Arg Lys Gln Met Ser Leu Leu Asn Ser Ser Glu 
        275                 280                 285             


Phe Gln Pro Gln Ile Arg Thr Val Ala Lys Ser His Ser Asp Ser Cys 
    290                 295                 300                 


Ile Leu Ser Ser Asn Asn Leu Pro Thr Lys Asp Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Gln Gly Asn Lys Leu Arg Asn Ala Met Val Ile Ser Ala Met 
                325                 330                 335     


Lys Ser Ser Pro Glu Thr Ser Met Leu Leu Asp Gln Val His Pro Pro 
            340                 345                 350         


Ile Asn Glu Asp Ser Leu Arg Ala Ser Thr Gln Ile Arg Ala Phe Ser 
        355                 360                 365             


Arg Asn Arg Phe Lys Asp His Ile Glu Asp His Leu Leu Pro Ser Thr 
    370                 375                 380                 


Glu Asn Thr Phe Trp Arg His Asp Thr Lys Ala Asp Thr Arg Ala Ile 
385                 390                 395                 400 


Gln Leu Leu Leu Gly Ser Ala Glu Leu Ser Gln Gly Asn Phe Trp Asp 
                405                 410                 415     


Gly Leu Gly Ser Pro Pro Asp Ser Pro Ser Pro Gly Ser Asp Val Tyr 
            420                 425                 430         


Cys Ile Ser Glu Leu Asn Asp Pro Gln Tyr Asp Gln Ser Leu Leu Glu 
        435                 440                 445             


Asn Leu Phe Tyr Thr Ala Pro Lys Ser Asp Thr Ser Ile Ser Asp Phe 
    450                 455                 460                 


Leu Ser Glu Glu Asp Asp Ile Val Pro Ser Lys Lys Ile Ser Gln Ser 
465                 470                 475                 480 


Thr Ala Leu Ala Arg Ser Ser Lys Val Leu Glu Ser Ser Asp His Lys 
                485                 490                 495     


Leu Lys Lys Arg Ser Ala Gly Lys Arg Asn Arg Asn Leu Val Glu Gln 
            500                 505                 510         


Gln Met Leu Ser Glu Thr Pro Glu Asp Ala Gln Thr Met Thr Leu Ser 
        515                 520                 525             


Val Asp Arg Leu Ala Leu Leu Gly Arg Thr His Ser Val Arg Ile Ile 
    530                 535                 540                 


Ile Glu Thr Met Gly Val Pro Pro Asp Ser Pro Gln Met Thr Pro Gly 
545                 550                 555                 560 


Lys Lys Ser Tyr Ala Gly Pro Pro Pro Lys Val Thr Thr Ala Lys Lys 
                565                 570                 575     


Arg Thr Phe Phe Val Glu Tyr His Phe Pro Val Gly Phe Ser Glu Ser 
            580                 585                 590         


Gly Leu Gly Lys Thr Ala Leu Ile Thr Glu Val Val Arg Leu Ala Ser 
        595                 600                 605             


Ser Lys Ile Thr Asp Gly Lys Val Lys Phe Gln Gln Arg Phe Val Phe 
    610                 615                 620                 


Pro Val Gln Phe Gly Gly Pro Met Ile Glu His Trp Trp Asn Ser Asn 
625                 630                 635                 640 


Leu Thr Phe Gln Ile Tyr Val Lys Lys Thr Pro Gln Lys Lys Pro Glu 
                645                 650                 655     


Val Ile Gly Ser Val Ser Leu Ser Leu Arg Ala Val Ile Gln Ser Glu 
            660                 665                 670         


Leu Leu Ser Phe Ser Asp Gln Leu Pro Val Gln Gln Glu Asn Gly Gln 
        675                 680                 685             


Ser Pro Phe Gly Pro Leu Lys Val Thr Met Glu Leu Ile Thr Asp Asn 
    690                 695                 700                 


Lys Asp Phe Thr Gly Ile Asn Thr Lys Leu Ser Gly Asn Thr His Tyr 
705                 710                 715                 720 


Thr Pro Leu Cys Ala Pro Thr Ser Pro Asn Lys Ala Leu Pro Glu Leu 
                725                 730                 735     


Asn Gln Asp Met Thr Cys Thr Lys Asn Pro Gln Asn Leu Asn Gln Ile 
            740                 745                 750         


His Glu Glu Thr Ala Lys Lys Ala Gln Asn Leu Val Leu Pro Asn Arg 
        755                 760                 765             


Lys Ser Pro Ser Pro Val Ala Pro His Pro Ser Thr Phe Val Ala Thr 
    770                 775                 780                 


Pro Ala Ser His Asn Leu Val Asn Gln Thr Asn Gly Thr Thr Lys Glu 
785                 790                 795                 800 


Ser Ala Leu Leu Leu His Val Leu Leu Met Val Pro Asp Gly Lys Asp 
                805                 810                 815     


Phe Ile Ser Gly Glu Ser Glu Lys Gln Ser Pro Cys Asn Val Tyr Leu 
            820                 825                 830         


Asn Cys Lys Leu Phe Ser Thr Glu Glu Val Thr Arg Ser Val Ile Ala 
        835                 840                 845             


Trp Gly Thr Thr Gln Pro Val Phe Asn Phe Ser Gln Val Ile Pro Val 
    850                 855                 860                 


Ser Leu Ser Ser Lys Tyr Leu Glu Arg Leu Lys Asn Asn Val Met Val 
865                 870                 875                 880 


Ile Glu Thr Trp Asn Lys Val Arg Ser Pro Gly Gln Asp Lys Leu Leu 
                885                 890                 895     


Gly Leu Val Lys Leu Pro Leu His Gln Phe Tyr Met Ser Phe Lys Asp 
            900                 905                 910         


Ala Lys Ile Ser Arg Leu Leu Leu Asp Ala Gln Tyr Pro Val Val Ala 
        915                 920                 925             


Val Asp Ser Tyr Met Pro Val Ile Asp Val Phe Ser Gly His Gln Asn 
    930                 935                 940                 


Gly Ser Leu Arg Val Phe Leu Ala Met Gly Ser Ser Asn Gln Ile Met 
945                 950                 955                 960 


Ala Leu Gln Arg Leu Lys Asn Glu Glu Gly Thr Leu Pro Pro Phe Ser 
                965                 970                 975     


Pro Arg Pro Ala His Phe Leu Asp Gln Pro Thr Ala Ala Ser Val Ala 
            980                 985                 990         


Met Ala Glu Asp Arg Gly Asn Gly  Leu Met Glu His Cys  Phe Glu Ile 
        995                 1000                 1005             


His Ile  Glu Met Val Lys Gly  Leu Ala Pro Leu Gln  Ala Thr Val 
    1010                 1015                 1020             


Trp Gly  Glu Ala Asp Cys Tyr  Val Gln Tyr Tyr Phe  Pro Val Gln 
    1025                 1030                 1035             


His Ser  Gln Ser Ser Val Leu  Lys Gly Pro Glu Phe  Leu Glu Asn 
    1040                 1045                 1050             


Gly Ile  Thr Leu Lys Pro Phe  Arg Thr Ala Thr Thr  Leu Cys Val 
    1055                 1060                 1065             


Pro Asp  Pro Ile Phe Asn Ser  Glu His His His Ser  Leu Leu Leu 
    1070                 1075                 1080             


Pro Ala  Glu Val Pro Val Gln  Arg Leu Leu Leu Ser  Ala Phe Ser 
    1085                 1090                 1095             


Ala Gln  Gly Leu Val Pro Gly  Gly Gly Val Gln Phe  Glu Ile Trp 
    1100                 1105                 1110             


Cys Arg  Tyr Tyr Tyr Pro Asn  Val Arg Asp Gln Lys  Val Ala Lys 
    1115                 1120                 1125             


Gly Thr  Leu Pro Leu Ser Arg  Ile Cys Ala Met Val  Thr Thr Gln 
    1130                 1135                 1140             


His Arg  Glu Asp Val Gly Ile  Gln Thr Phe Asn Leu  Pro Leu Thr 
    1145                 1150                 1155             


Pro Arg  Ile Glu Asn Arg Lys  Glu Leu Arg Asn Gln  Ser Ser Gly 
    1160                 1165                 1170             


Leu Leu  Asp Val Gly Leu Arg  Tyr Arg Arg Ser Pro  Arg Thr Ala 
    1175                 1180                 1185             


Glu Gly  Val Leu Ala Ala Arg  Thr Val Ser Ile Ser  Val Gln Ile 
    1190                 1195                 1200             


Ile Arg  Ala Cys Gly Leu Gln  Ala Ala Ala Lys Ala  Leu Ala Glu 
    1205                 1210                 1215             


Arg Glu  Pro Ala Leu Gln Phe  Ser Ala Thr Val Gly  Val Asn Ala 
    1220                 1225                 1230             


Ser Val  Thr Thr His Leu Ser  Phe Leu Pro Gln Gly  Glu Gln Arg 
    1235                 1240                 1245             


Arg Thr  His Pro Val Ala Cys  Ser Phe Cys Pro Glu  Phe Ser His 
    1250                 1255                 1260             


His Val  Glu Phe Thr Cys Asn  Leu Val Thr Gln His  Cys Ser Gly 
    1265                 1270                 1275             


Glu Ala  Cys Phe Leu Ala Glu  Leu Leu Glu Phe Ala  Glu Val Ile 
    1280                 1285                 1290             


Phe Ala  Val Tyr His Glu Asn  Thr Lys Ser Ala Ser  Asp Ile Ile 
    1295                 1300                 1305             


Ser Ile  Glu Ser Cys Lys Glu  Tyr Leu Leu Gly Val  Val Lys Val 
    1310                 1315                 1320             


Pro Thr  Lys Glu Leu Leu Ile  Lys Arg Ser Gly Ile  Thr Gly Trp 
    1325                 1330                 1335             


Tyr Pro  Ile Ile Leu Pro Glu  Asp Gly Gly Leu Pro  His Gly Leu 
    1340                 1345                 1350             


Glu Leu  Met Gln Lys Ile Val  Gly Gly Leu Glu Leu  Ser Ile Ser 
    1355                 1360                 1365             


Phe Thr  His Arg Gly Asp Arg  Glu Arg Val Leu Glu  Ala Ala Glu 
    1370                 1375                 1380             


His Leu  Gly Trp Ser Phe Glu  Asn Ser Leu Lys Asp  Phe Val Arg 
    1385                 1390                 1395             


Met Asp  Glu Gly Glu Pro Ala  Thr Val Thr Ile Ser  Thr Pro Arg 
    1400                 1405                 1410             


Leu Trp  Leu Pro Ile His Cys  Val Leu Leu Ala Gly  His Asn His 
    1415                 1420                 1425             


Ile His  Lys Asn Thr Tyr Cys  Tyr Leu Arg Tyr Lys  Phe Tyr Asp 
    1430                 1435                 1440             


His Glu  Ala Phe Trp Thr Pro  Leu Lys Lys Pro Lys  Glu Ser Val 
    1445                 1450                 1455             


Asn Lys  Lys Gln Ile Met Val  Thr Phe Lys Ala Ser  Lys Arg Ala 
    1460                 1465                 1470             


Glu Val  Thr Arg Gly Pro Ser  Leu Leu Trp Tyr Phe  Arg Glu Glu 
    1475                 1480                 1485             


Arg Leu  Glu Ile Gln Val Trp  Arg Ala Tyr Gly Asn  Asp Ser Val 
    1490                 1495                 1500             


Glu Arg  Pro His Gln Thr Asp  Ser Trp Ile Gly Ser  Ala Tyr Val 
    1505                 1510                 1515             


Asp Leu  Ala Arg Leu Gly Glu  Arg Ser Ala Arg Thr  Leu Thr Val 
    1520                 1525                 1530             


Ser Gly  Val Tyr Pro Leu Phe  Gly Arg Asn Ala Ser  Asn Leu Ser 
    1535                 1540                 1545             


Gly Ala  Ala Leu Arg Val His  Val Val Leu Ser Ser  Leu Ser Ser 
    1550                 1555                 1560             


His Leu  Glu Pro Thr His Glu  Leu Asp Ser Met Asp  Cys Ser Ser 
    1565                 1570                 1575             


His Ser  Glu Ser Glu Gln Leu  Pro Arg Arg Asn Asp  Glu Val Gln 
    1580                 1585                 1590             


Leu Ser  Pro Pro Glu Val Ile  Ser Cys His Gln Lys  Ser Pro Ala 
    1595                 1600                 1605             


Ser Thr  Gln Val Pro Cys Ser  Ser Thr Thr Ala Glu  Val Arg Leu 
    1610                 1615                 1620             


Thr Gln  Glu Gly Pro Ala Asp  Leu Asp Gly Thr Phe  Ala Val Ser 
    1625                 1630                 1635             


Ile Leu  Val Glu Arg Ala Met  His Leu Ser Leu Lys  Gly Ser Pro 
    1640                 1645                 1650             


Leu Thr  Glu Arg Lys Val Ser  Ile Pro Ser Cys Cys  Val Ser Phe 
    1655                 1660                 1665             


Ala Thr  Ala Asp Glu Ser Ser  Pro Val Tyr Thr Gln  Val Val Glu 
    1670                 1675                 1680             


Asn Thr  Asp Ser Pro Ile Trp  Asn Phe Gln Gln Gln  Ser Arg Leu 
    1685                 1690                 1695             


Ser Lys  Glu Leu Leu Leu Asp  Pro Gln Gln Thr Leu  Val Phe Lys 
    1700                 1705                 1710             


Val Trp  His Lys Gly Asp Glu  Glu Arg Val Ile Gly  Phe Ala Ser 
    1715                 1720                 1725             


Val Asp  Leu Ser Pro Leu Leu  Ser Gly Phe Gln Phe  Val Cys Gly 
    1730                 1735                 1740             


Trp Tyr  Asn Ile Thr Asp Phe  Ser Gly Glu Cys Gln  Gly Gln Ile 
    1745                 1750                 1755             


Lys Val  Ala Val Ser Pro Leu  Glu Ser Leu Ile His  Phe Lys Glu 
    1760                 1765                 1770             


Glu Arg  Gln Ala Arg Arg Gly  Val Glu Thr Ser Lys  Ser Leu Ile 
    1775                 1780                 1785             


Pro Ile  Tyr Ser Pro Phe Ser  Phe Pro Ala Ser Asp  Thr Tyr Ala 
    1790                 1795                 1800             


Ala Phe  Ser Ser His Met Ala  Arg Gln Thr Leu Asp  Gln Leu Ala 
    1805                 1810                 1815             


His Ala  Ser Ser Lys Glu Leu  Asp Phe Ser Ser Pro  Gly Arg Ser 
    1820                 1825                 1830             


Asp Thr  Thr Arg Ser Gln Ala  Ser Arg His Glu Glu  His Val Gln 
    1835                 1840                 1845             


Asn Ile  Arg Arg Phe His Glu  Ser Leu His Leu Gln  Gly Glu Ala 
    1850                 1855                 1860             


Pro Leu  Pro Cys Asp Asp Lys  Leu Thr Thr Ser Pro  Leu Ser Ser 
    1865                 1870                 1875             


Gln Thr  Ser Ile Leu Thr Ser  Leu Arg Lys Asn Leu  Ser Glu Leu 
    1880                 1885                 1890             


Asp Gln  Ile Gln Arg Tyr Phe  Arg Gln Lys Leu Thr  Lys Pro Phe 
    1895                 1900                 1905             


Leu Pro  Leu Ser Pro Gln Thr  Gln Thr Ala Ile Ser  Gln His Gln 
    1910                 1915                 1920             


Glu Ser  Cys Arg Asp His Leu  Gly Pro Gly Ala Ser  Ser Leu Asp 
    1925                 1930                 1935             


Pro Gly  Ser Gln Cys Ile Leu  Glu Lys Ser Ser Asn  Leu Val Leu 
    1940                 1945                 1950             


Gln Val  Ser Ser Leu Ile Thr  Asp Leu Gln Thr Ile  Thr Arg Asp 
    1955                 1960                 1965             


Ser Gln  Ala Ala Leu Ser Ser  His Arg Ala Arg Ser  Arg Ser Asn 
    1970                 1975                 1980             


Lys Ala  Thr Thr Leu Pro Asp  Ala Gln Asp Thr Glu  Ala Leu Gln 
    1985                 1990                 1995             


Glu Arg  Cys Thr Met Pro Asp  Glu Pro Leu Val Arg  Ala Pro Asp 
    2000                 2005                 2010             


Lys Gly  Thr Asp Ser Pro Ser  Pro Pro Pro Leu Glu  Glu Thr Ser 
    2015                 2020                 2025             


Asn Gly  Gly Arg Met Leu His  Glu Ser Leu Arg His  Ala Val Pro 
    2030                 2035                 2040             


Ile Thr  Arg Met Gln Ser Ser  Glu Asp Thr Glu Ala  Gly Pro Ala 
    2045                 2050                 2055             


Tyr Ser  Asp Glu Asp Tyr Glu  Glu Asp Ile Ile Glu  Pro Arg Thr 
    2060                 2065                 2070             


Leu Asn  Glu Ile Thr Thr Val  Thr Asp Lys Thr Ser  Pro Trp Ser 
    2075                 2080                 2085             


Ser Val  Ile Ser Asp Thr Ser  Glu Val Ile Ser Pro  Gln Pro Asp 
    2090                 2095                 2100             


Glu Val  Gln Arg Glu Gly Pro  Ser Cys Pro Ser Pro  Gly Pro Phe 
    2105                 2110                 2115             


Cys Arg  Glu Glu Leu Met Val  Lys Ser Ser Phe Leu  Ser Ser Pro 
    2120                 2125                 2130             


Glu Arg  Ala Val Asn Pro His  Leu Pro Arg Gln Gly  Ser Pro Ser 
    2135                 2140                 2145             


Gln Ser  Leu Val Ala Cys Glu  Cys Glu Ala Ser Lys  Ala Arg Val 
    2150                 2155                 2160             


Gly Gly  Glu Ser Ala Ser Ala  Asn Pro Gln Pro Ile  Pro Cys Pro 
    2165                 2170                 2175             


Thr Leu  Ser Gly Ala Gln Gln  Ser Ser Thr Phe Val  Gly Trp Ser 
    2180                 2185                 2190             


Ser Pro  Gln Thr Asp Gln Asn  Lys Glu Pro Lys Ser  Glu Ala Pro 
    2195                 2200                 2205             


Ala Glu  Asn Glu Ala Ala Thr  Ser Glu Leu Gly Asp  Ser Ala Asp 
    2210                 2215                 2220             


Ser Phe  Lys Lys Leu Pro Leu  Asn Leu Ala Ser Gln  Ser Arg Arg 
    2225                 2230                 2235             


Glu Asn  His Lys Gly Pro Pro  Ile Asp Ser Ser Asp  Ile Arg Gln 
    2240                 2245                 2250             


Arg Gln  Val Thr Thr Gly Ser  Glu Thr Ser Thr Lys  Gln Ser Leu 
    2255                 2260                 2265             


Leu Leu  Pro Gly Pro Ile Val  Val Pro Asn Phe Phe  Leu Pro Pro 
    2270                 2275                 2280             


Gln Gln  Leu Glu Ala Ser Leu  Arg Met Leu Ser Leu  Ser Ala Thr 
    2285                 2290                 2295             


Leu Pro  Pro Ala Ala Thr Thr  Asp Gln Asp Lys Ser  Glu Ala Thr 
    2300                 2305                 2310             


Arg Gly  Ala Leu Ser Gln Arg  Pro Cys Arg Pro Arg  Pro Asn Ser 
    2315                 2320                 2325             


Leu Pro  Leu Asn Leu Pro Glu  Glu Glu Thr Leu Arg  Ile Ala Arg 
    2330                 2335                 2340             


Ile Phe  Ser Ser Gln Tyr Ser  Gln Lys Asp 
    2345                 2350             


<210>  1395
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2CD4A__Homo_sapiens__NP_997205

<400>  1395

Met Trp Cys Leu Glu Arg Leu Arg Leu Gly Pro Glu Cys Leu Arg Arg 
1               5                   10                  15      


Ser Gly Asp Trp Leu Leu Pro Gly Arg Ala Arg Gly Ala Lys Ser Arg 
            20                  25                  30          


Thr Thr Ala Ala Cys Ala Asn Val Leu Thr Pro Asp Arg Ile Pro Glu 
        35                  40                  45              


Phe Cys Ile Pro Pro Arg Leu Met Pro Arg Leu Ala Leu Ala Ala Leu 
    50                  55                  60                  


Arg Asn Ser Trp Val Glu Glu Ala Gly Met Asp Glu Gly Ala Gly Arg 
65                  70                  75                  80  


Thr Asp Trp Asp Pro Arg Ser Gln Ala Ala Leu Ser Leu Pro His Leu 
                85                  90                  95      


Pro Arg Val Arg Thr Ala Tyr Gly Phe Cys Ala Leu Leu Glu Ser Pro 
            100                 105                 110         


His Thr Arg Arg Lys Glu Ser Leu Leu Leu Gly Gly Pro Pro Ala Pro 
        115                 120                 125             


Arg Pro Arg Ala His Thr Tyr Gly Gly Gly Gly Gly Pro Asp Ala Leu 
    130                 135                 140                 


Leu Gly Thr Leu Arg Val Pro Arg Ala Pro Gly Pro Ala Thr Pro Ala 
145                 150                 155                 160 


Ala Pro Gly Cys Pro Arg Pro Pro Gln Asp Ala Leu Ala Arg Arg Pro 
                165                 170                 175     


Arg Gly Cys Arg Leu Leu Arg Val Pro Asp Gly Leu Leu Ser Arg Ala 
            180                 185                 190         


Leu Arg Ala Gly Arg Ser Arg Arg Leu Thr Arg Val Arg Ser Val Ser 
        195                 200                 205             


Ser Gly Asn Glu Asp Lys Glu Arg Arg Ala Gly Ser Gln Ser Pro Ala 
    210                 215                 220                 


Arg Ala Pro Ser Thr Ser Pro Pro Ser Ser Arg Val Pro Phe Pro Glu 
225                 230                 235                 240 


Arg Leu Glu Ala Glu Gly Thr Val Ala Leu Gly Arg Ala Gly Asp Ala 
                245                 250                 255     


Leu Arg Leu Ala Ala Glu Tyr Cys Pro Gly Thr Gly Arg Leu Arg Leu 
            260                 265                 270         


Arg Leu Leu Arg Ala Glu Ser Pro Ala Gly Gly Ala Pro Gly Pro Arg 
        275                 280                 285             


Ala Val Ser Cys Arg Leu Ser Leu Val Leu Arg Pro Pro Gly Thr Ala 
    290                 295                 300                 


Leu Arg Gln Cys Ser Thr Val Val Gly Arg Ser Arg Lys Ala Ser Phe 
305                 310                 315                 320 


Asp Gln Asp Phe Cys Phe Asp Gly Leu Ser Glu Asp Glu Val Arg Arg 
                325                 330                 335     


Leu Ala Val Arg Val Lys Ala Arg Asp Glu Gly Arg Gly Arg Glu Arg 
            340                 345                 350         


Gly Arg Leu Leu Gly Gln Gly Glu Leu Ser Leu Gly Ala Leu Leu Leu 
        355                 360                 365             


Leu 
    


<210>  1396
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2CD4B__Homo_sapiens__NP_001007596

<400>  1396

Met Arg Leu Leu Glu Lys Leu Cys Ser Ser Ala Ala Gly Ser Ser Ala 
1               5                   10                  15      


Pro Lys Pro Ala Phe Ala Lys Val Leu Thr Pro Asn Arg Ile Pro Glu 
            20                  25                  30          


Phe Cys Ile Pro Pro Arg Leu Pro Ala Pro Cys Thr Leu Glu Ser Pro 
        35                  40                  45              


Ile Arg Ala Ala Ala Val Pro Arg Arg Cys Ala Ala Glu Ser Asp Leu 
    50                  55                  60                  


Trp Pro Arg Ala Ala Asp Glu Asp Ala Gly Arg Thr Asp Trp Asp Pro 
65                  70                  75                  80  


Arg Ser Gln Ala Ala Leu Ser Leu Pro His Leu Pro Arg Val Arg Thr 
                85                  90                  95      


Thr Tyr Gly Phe Cys Ala Leu Leu Glu Ser Pro His Thr Arg Arg Lys 
            100                 105                 110         


Glu Ser Leu Leu Leu Gly Gly Pro Pro Ala Pro Arg Pro Arg Ala His 
        115                 120                 125             


Ser Cys Gly Gly Gly Gly Gly Pro Asp Ala Pro Leu Gly Thr Leu Cys 
    130                 135                 140                 


Gly Pro Arg Gly Pro Gly Pro Ala Thr Pro Ala Ala Pro Gly Gly Pro 
145                 150                 155                 160 


Arg Leu Pro Gln Asp Ala Leu Ala Ala Gly Pro Arg Arg Cys Arg Leu 
                165                 170                 175     


Leu Arg Val Pro Asp Gly Leu Leu Ser Arg Ala Leu Arg Ala Gly Arg 
            180                 185                 190         


Ser Arg Arg Leu Ala Arg Val Arg Ser Val Ser Ser Gly Asn Glu Asp 
        195                 200                 205             


Glu Glu Arg Arg Ala Gly Ser Glu Ser Pro Ala Arg Ala Pro Ser Ser 
    210                 215                 220                 


Ser Pro Leu Ser Ser Arg Ala Pro Leu Pro Glu Arg Leu Glu Ala Lys 
225                 230                 235                 240 


Gly Thr Val Ala Leu Gly Arg Ala Gly Asp Ala Leu Arg Leu Ala Ala 
                245                 250                 255     


Glu Tyr Cys Pro Gly Thr Arg Arg Leu Arg Leu Arg Leu Leu Arg Ala 
            260                 265                 270         


Glu Ser Leu Phe Gly Gly Ala Pro Gly Pro Arg Ala Val Arg Cys Arg 
        275                 280                 285             


Leu Ser Leu Val Leu Arg Pro Pro Gly Thr Ala Arg Trp Gln Cys Ser 
    290                 295                 300                 


Ala Val Val Gly Arg Ser Arg Lys Ala Ser Phe Asp Gln Asp Phe Cys 
305                 310                 315                 320 


Phe Asp Gly Leu Ser Glu Asp Glu Val Arg Arg Leu Ala Val Arg Val 
                325                 330                 335     


Lys Ala Arg Asp Glu Gly Arg Gly Arg Asp Arg Gly Arg Leu Leu Gly 
            340                 345                 350         


Gln Gly Glu Leu Ser Leu Gly Ala Leu Leu Leu Leu 
        355                 360                 


<210>  1397
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2CD5__Homo_sapiens__NP_001273104

<400>  1397

Met Pro Gly Lys Leu Lys Val Lys Ile Val Ala Gly Arg His Leu Pro 
1               5                   10                  15      


Val Met Asp Arg Ala Ser Asp Leu Thr Asp Ala Phe Val Glu Val Lys 
            20                  25                  30          


Phe Gly Asn Thr Thr Phe Lys Thr Asp Val Tyr Leu Lys Ser Leu Asn 
        35                  40                  45              


Pro Gln Trp Asn Ser Glu Trp Phe Lys Phe Glu Val Asp Asp Glu Asp 
    50                  55                  60                  


Leu Gln Asp Glu Pro Leu Gln Ile Thr Val Leu Asp His Asp Thr Tyr 
65                  70                  75                  80  


Ser Ala Asn Asp Ala Ile Gly Lys Val Tyr Ile Asp Ile Asp Pro Leu 
                85                  90                  95      


Leu Tyr Ser Glu Ala Ala Thr Val Ile Ser Gly Trp Phe Pro Ile Tyr 
            100                 105                 110         


Asp Thr Ile His Gly Ile Arg Gly Glu Ile Asn Val Val Val Lys Val 
        115                 120                 125             


Asp Leu Phe Asn Asp Leu Asn Arg Phe Arg Gln Ser Ser Cys Gly Val 
    130                 135                 140                 


Lys Phe Phe Cys Thr Thr Ser Ile Pro Lys Cys Tyr Arg Ala Val Ile 
145                 150                 155                 160 


Ile His Gly Phe Val Glu Glu Leu Val Val Asn Glu Asp Pro Glu Tyr 
                165                 170                 175     


Gln Trp Ile Asp Arg Ile Arg Thr Pro Arg Ala Ser Asn Glu Ala Arg 
            180                 185                 190         


Gln Arg Leu Ile Ser Leu Met Ser Gly Glu Leu Gln Arg Lys Ile Gly 
        195                 200                 205             


Leu Lys Val Leu Glu Met Arg Gly Asn Ala Val Val Gly Tyr Leu Gln 
    210                 215                 220                 


Cys Phe Asp Leu Glu Gly Glu Ser Gly Leu Val Val Arg Ala Ile Gly 
225                 230                 235                 240 


Thr Ala Cys Thr Leu Asp Lys Leu Ser Ser Pro Ala Ala Phe Leu Pro 
                245                 250                 255     


Ala Cys Asn Ser Pro Ser Lys Glu Met Lys Glu Ser Pro Leu Val His 
            260                 265                 270         


Pro Pro Ser His Gly Cys Arg Ser Thr His Asn Ser Pro Ile His Thr 
        275                 280                 285             


Ala Thr Gly Ser Arg Leu Thr Gln Asn Phe Ser Val Ser Val Pro Thr 
    290                 295                 300                 


Leu Ile Tyr Thr Gly Met Gly Ser Gly Ser Ala Gly Lys Glu Gly Gly 
305                 310                 315                 320 


Pro Phe Lys Ala Leu Leu Arg Gln Gln Thr Gln Ser Ala Leu Glu Gln 
                325                 330                 335     


Arg Glu Phe Pro Phe Phe Thr Leu Thr Ala Phe Pro Pro Gly Phe Leu 
            340                 345                 350         


Val His Val Gly Gly Val Val Ser Ala Arg Ser Val Lys Leu Leu Asp 
        355                 360                 365             


Arg Ile His Asn Pro Ala Phe Val Gly Ile Met Gly Asn Thr Arg Ser 
    370                 375                 380                 


Tyr Lys Leu Leu Asp Trp Asn Ser Phe Asn Ser Asp Glu Pro Glu Thr 
385                 390                 395                 400 


Arg Asp Ala Trp Trp Ala Glu Ile Arg Gln Glu Ile Lys Ser His Ala 
                405                 410                 415     


Lys Ala Leu Gly Cys His Ala Val Val Gly Tyr Ser Glu Ser Thr Ser 
            420                 425                 430         


Ile Cys Glu Glu Val Cys Ile Leu Ser Ala Ser Gly Thr Ala Ala Val 
        435                 440                 445             


Leu Asn Pro Arg Phe Leu Gln Asp Gly Thr Val Glu Gly Cys Leu Glu 
    450                 455                 460                 


Gln Arg Leu Glu Glu Asn Leu Pro Thr Arg Cys Gly Phe Cys His Ile 
465                 470                 475                 480 


Pro Tyr Asp Glu Leu Asn Met Pro Phe Pro Ala His Leu Thr Tyr Cys 
                485                 490                 495     


Tyr Asn Cys Arg Lys Gln Lys Val Pro Asp Val Leu Phe Thr Thr Ile 
            500                 505                 510         


Asp Leu Pro Thr Asp Ala Thr Val Ile Gly Lys Gly Cys Leu Ile Gln 
        515                 520                 525             


Ala Arg Leu Cys Arg Leu Lys Lys Lys Ala Gln Ala Glu Ala Asn Ala 
    530                 535                 540                 


Thr Ala Ile Ser Asn Leu Leu Pro Phe Met Glu Tyr Glu Val His Thr 
545                 550                 555                 560 


Gln Leu Met Asn Lys Leu Lys Leu Lys Gly Met Asn Ala Leu Phe Gly 
                565                 570                 575     


Leu Arg Ile Gln Ile Thr Val Gly Glu Asn Met Leu Met Gly Leu Ala 
            580                 585                 590         


Ser Ala Thr Gly Val Tyr Leu Ala Ala Leu Pro Thr Pro Gly Gly Ile 
        595                 600                 605             


Gln Ile Ala Gly Lys Thr Pro Asn Asp Gly Ser Tyr Glu Gln His Ile 
    610                 615                 620                 


Ser His Met Gln Lys Lys Ile Asn Asp Thr Ile Ala Lys Asn Lys Glu 
625                 630                 635                 640 


Leu Tyr Glu Ile Asn Pro Pro Glu Ile Ser Glu Glu Ile Ile Gly Ser 
                645                 650                 655     


Pro Ile Pro Glu Pro Arg Gln Arg Ser Arg Leu Leu Arg Ser Gln Ser 
            660                 665                 670         


Glu Ser Ser Asp Glu Val Thr Glu Leu Asp Leu Ser His Gly Lys Lys 
        675                 680                 685             


Asp Ala Phe Val Leu Glu Ile Asp Asp Thr Asp Ala Met Glu Asp Val 
    690                 695                 700                 


His Ser Leu Leu Thr Asp Val Pro Pro Pro Ser Gly Phe Tyr Ser Cys 
705                 710                 715                 720 


Asn Thr Glu Ile Met Pro Gly Ile Asn Asn Trp Thr Ser Glu Ile Gln 
                725                 730                 735     


Met Phe Thr Ser Val Arg Val Ile Arg Leu Ser Ser Leu Asn Leu Thr 
            740                 745                 750         


Asn Gln Ala Leu Asn Lys Asn Phe Asn Asp Leu Cys Glu Asn Leu Leu 
        755                 760                 765             


Lys Ser Leu Tyr Phe Lys Leu Arg Ser Met Ile Pro Cys Cys Leu Cys 
    770                 775                 780                 


His Val Asn Phe Thr Val Ser Leu Pro Glu Asp Glu Leu Ile Gln Val 
785                 790                 795                 800 


Thr Val Thr Ala Val Ala Ile Thr Phe Asp Lys Asn Gln Ala Leu Gln 
                805                 810                 815     


Thr Thr Lys Thr Pro Val Glu Lys Ser Leu Gln Arg Ala Ser Thr Asp 
            820                 825                 830         


Asn Glu Glu Leu Leu Gln Phe Pro Leu Glu Leu Cys Ser Asp Ser Leu 
        835                 840                 845             


Pro Ser His Pro Phe Pro Pro Ala Lys Glu His Leu Glu Ser Ala Ser 
    850                 855                 860                 


Ser Asn Ser Gly Ile Pro Ala Ala Gln Arg Asp Arg Cys Ser Ser Trp 
865                 870                 875                 880 


Ile Glu Leu Ile Lys Leu Lys Ala Gln Thr Ile Arg Arg Gly Ser Ile 
                885                 890                 895     


Lys Thr Thr Met Thr Val Glu Lys Ala Ser Pro Val Gly Asp Gly Asn 
            900                 905                 910         


Phe Arg Asn Arg Ser Ala Pro Pro Cys Ala Asn Ser Thr Val Gly Val 
        915                 920                 925             


Val Lys Met Thr Pro Leu Ser Phe Ile Pro Gly Ala Lys Ile Thr Lys 
    930                 935                 940                 


Tyr Leu Gly Ile Ile Asn Met Phe Phe Ile Arg Glu Thr Thr Ser Leu 
945                 950                 955                 960 


Arg Glu Glu Gly Gly Val Ser Gly Phe Leu His Ala Phe Ile Ala Glu 
                965                 970                 975     


Val Phe Ala Met Val Arg Ala His Val Ala Ala Leu Gly Gly Asn Ala 
            980                 985                 990         


Val Val Ser Tyr Ile Met Lys Gln  Cys Val Phe Met Glu  Asn Pro Asn 
        995                 1000                 1005             


Lys Asn  Gln Ala Gln Cys Leu  Ile Asn Val Ser Gly  Asp Ala Val 
    1010                 1015                 1020             


Val Phe  Val Arg Glu Ser Asp  Leu Glu Val Val Ser  Ser Gln Gln 
    1025                 1030                 1035             


Pro Thr  Thr Asn Cys Gln Ser  Ser Cys Thr Glu Gly  Glu Val Thr 
    1040                 1045                 1050             


Thr 
    


<210>  1398
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2__Homo_sapiens__NP_000054

<400>  1398

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser Ala Pro Ser Cys Pro Gln Asn Val Asn Ile Ser Gly 
            20                  25                  30          


Gly Thr Phe Thr Leu Ser His Gly Trp Ala Pro Gly Ser Leu Leu Thr 
        35                  40                  45              


Tyr Ser Cys Pro Gln Gly Leu Tyr Pro Ser Pro Ala Ser Arg Leu Cys 
    50                  55                  60                  


Lys Ser Ser Gly Gln Trp Gln Thr Pro Gly Ala Thr Arg Ser Leu Ser 
65                  70                  75                  80  


Lys Ala Val Cys Lys Pro Val Arg Cys Pro Ala Pro Val Ser Phe Glu 
                85                  90                  95      


Asn Gly Ile Tyr Thr Pro Arg Leu Gly Ser Tyr Pro Val Gly Gly Asn 
            100                 105                 110         


Val Ser Phe Glu Cys Glu Asp Gly Phe Ile Leu Arg Gly Ser Pro Val 
        115                 120                 125             


Arg Gln Cys Arg Pro Asn Gly Met Trp Asp Gly Glu Thr Ala Val Cys 
    130                 135                 140                 


Asp Asn Gly Ala Gly His Cys Pro Asn Pro Gly Ile Ser Leu Gly Ala 
145                 150                 155                 160 


Val Arg Thr Gly Phe Arg Phe Gly His Gly Asp Lys Val Arg Tyr Arg 
                165                 170                 175     


Cys Ser Ser Asn Leu Val Leu Thr Gly Ser Ser Glu Arg Glu Cys Gln 
            180                 185                 190         


Gly Asn Gly Val Trp Ser Gly Thr Glu Pro Ile Cys Arg Gln Pro Tyr 
        195                 200                 205             


Ser Tyr Asp Phe Pro Glu Asp Val Ala Pro Ala Leu Gly Thr Ser Phe 
    210                 215                 220                 


Ser His Met Leu Gly Ala Thr Asn Pro Thr Gln Lys Thr Lys Glu Ser 
225                 230                 235                 240 


Leu Gly Arg Lys Ile Gln Ile Gln Arg Ser Gly His Leu Asn Leu Tyr 
                245                 250                 255     


Leu Leu Leu Asp Cys Ser Gln Ser Val Ser Glu Asn Asp Phe Leu Ile 
            260                 265                 270         


Phe Lys Glu Ser Ala Ser Leu Met Val Asp Arg Ile Phe Ser Phe Glu 
        275                 280                 285             


Ile Asn Val Ser Val Ala Ile Ile Thr Phe Ala Ser Glu Pro Lys Val 
    290                 295                 300                 


Leu Met Ser Val Leu Asn Asp Asn Ser Arg Asp Met Thr Glu Val Ile 
305                 310                 315                 320 


Ser Ser Leu Glu Asn Ala Asn Tyr Lys Asp His Glu Asn Gly Thr Gly 
                325                 330                 335     


Thr Asn Thr Tyr Ala Ala Leu Asn Ser Val Tyr Leu Met Met Asn Asn 
            340                 345                 350         


Gln Met Arg Leu Leu Gly Met Glu Thr Met Ala Trp Gln Glu Ile Arg 
        355                 360                 365             


His Ala Ile Ile Leu Leu Thr Asp Gly Lys Ser Asn Met Gly Gly Ser 
    370                 375                 380                 


Pro Lys Thr Ala Val Asp His Ile Arg Glu Ile Leu Asn Ile Asn Gln 
385                 390                 395                 400 


Lys Arg Asn Asp Tyr Leu Asp Ile Tyr Ala Ile Gly Val Gly Lys Leu 
                405                 410                 415     


Asp Val Asp Trp Arg Glu Leu Asn Glu Leu Gly Ser Lys Lys Asp Gly 
            420                 425                 430         


Glu Arg His Ala Phe Ile Leu Gln Asp Thr Lys Ala Leu His Gln Val 
        435                 440                 445             


Phe Glu His Met Leu Asp Val Ser Lys Leu Thr Asp Thr Ile Cys Gly 
    450                 455                 460                 


Val Gly Asn Met Ser Ala Asn Ala Ser Asp Gln Glu Arg Thr Pro Trp 
465                 470                 475                 480 


His Val Thr Ile Lys Pro Lys Ser Gln Glu Thr Cys Arg Gly Ala Leu 
                485                 490                 495     


Ile Ser Asp Gln Trp Val Leu Thr Ala Ala His Cys Phe Arg Asp Gly 
            500                 505                 510         


Asn Asp His Ser Leu Trp Arg Val Asn Val Gly Asp Pro Lys Ser Gln 
        515                 520                 525             


Trp Gly Lys Glu Phe Leu Ile Glu Lys Ala Val Ile Ser Pro Gly Phe 
    530                 535                 540                 


Asp Val Phe Ala Lys Lys Asn Gln Gly Ile Leu Glu Phe Tyr Gly Asp 
545                 550                 555                 560 


Asp Ile Ala Leu Leu Lys Leu Ala Gln Lys Val Lys Met Ser Thr His 
                565                 570                 575     


Ala Arg Pro Ile Cys Leu Pro Cys Thr Met Glu Ala Asn Leu Ala Leu 
            580                 585                 590         


Arg Arg Pro Gln Gly Ser Thr Cys Arg Asp His Glu Asn Glu Leu Leu 
        595                 600                 605             


Asn Lys Gln Ser Val Pro Ala His Phe Val Ala Leu Asn Gly Ser Lys 
    610                 615                 620                 


Leu Asn Ile Asn Leu Lys Met Gly Val Glu Trp Thr Ser Cys Ala Glu 
625                 630                 635                 640 


Val Val Ser Gln Glu Lys Thr Met Phe Pro Asn Leu Thr Asp Val Arg 
                645                 650                 655     


Glu Val Val Thr Asp Gln Phe Leu Cys Ser Gly Thr Gln Glu Asp Glu 
            660                 665                 670         


Ser Pro Cys Lys Gly Glu Ser Gly Gly Ala Val Phe Leu Glu Arg Arg 
        675                 680                 685             


Phe Arg Phe Phe Gln Val Gly Leu Val Ser Trp Gly Leu Tyr Asn Pro 
    690                 695                 700                 


Cys Leu Gly Ser Ala Asp Lys Asn Ser Arg Lys Arg Ala Pro Arg Ser 
705                 710                 715                 720 


Lys Val Pro Pro Pro Arg Asp Phe His Ile Asn Leu Phe Arg Met Gln 
                725                 730                 735     


Pro Trp Leu Arg Gln His Leu Gly Asp Val Leu Asn Phe Leu Pro Leu 
            740                 745                 750         


<210>  1399
<211>  1984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2orf16__Homo_sapiens__NP_115642

<400>  1399

Met Glu Leu Thr Pro Gly Ala Gln Gln Gln Gly Ile Asn Tyr Gln Glu 
1               5                   10                  15      


Leu Thr Ser Gly Trp Gln Asp Val Lys Ser Met Met Leu Val Pro Glu 
            20                  25                  30          


Pro Thr Arg Lys Phe Pro Ser Gly Pro Leu Leu Thr Ser Val Arg Phe 
        35                  40                  45              


Ser Asn Leu Ser Pro Glu Ser Gln Gln Gln Asp Val Lys Ser Leu Glu 
    50                  55                  60                  


Phe Thr Val Glu Pro Lys Leu Gln Ser Val Lys His Val Lys Leu Ser 
65                  70                  75                  80  


Ser Val Ser Leu Gln Gln Thr Ile Lys Ser Val Glu Leu Ala Pro Gly 
                85                  90                  95      


Ser Leu Pro Gln Arg Val Lys Tyr Gly Glu Gln Thr Pro Arg Thr Asn 
            100                 105                 110         


Tyr Gln Ile Met Glu Ser Ser Glu Leu Ile Pro Arg Pro Gly His Gln 
        115                 120                 125             


Phe Ala Lys Tyr Ala Glu Met Ile Pro Gln Pro Lys Tyr Gln Ile Pro 
    130                 135                 140                 


Lys Ser Ala Asn Leu Ile Ser Ile Pro Ile Tyr His Ala Thr Glu Ser 
145                 150                 155                 160 


Ser Glu Met Ala Gln Gly Leu Ala Tyr Lys Gly Ile Asp Thr Val Glu 
                165                 170                 175     


Lys Ser Val Gly Leu Thr Pro Lys Leu Thr Gly Arg Ala Lys Glu Ser 
            180                 185                 190         


Leu Gly Met Leu Leu Gln Pro Asp Leu Gln Val Pro Lys Phe Val Asp 
        195                 200                 205             


Leu Thr Pro Met Val Arg Asp Gln Gly Ser Lys Phe Leu Gly Leu Thr 
    210                 215                 220                 


Pro Glu Lys Ser Tyr Gln Ile Leu Glu Thr Met Glu Leu Leu Ser Gln 
225                 230                 235                 240 


Ser Arg Pro Arg Val Lys Asp Val Gly Glu Leu Tyr Met Lys Pro Leu 
                245                 250                 255     


Gln Gln Thr Val Glu Tyr Glu Gly Ile Thr Pro Glu Leu Lys His Tyr 
            260                 265                 270         


Phe Thr Glu Ala Met Gly Leu Thr Ala Glu Ala Arg Ile Gln Ala Asn 
        275                 280                 285             


Glu Phe Phe Gly Met Thr Pro Lys Pro Thr Ser Gln Ala Thr Gly Phe 
    290                 295                 300                 


Ala Glu Arg Ser Pro Arg Leu Cys Pro Gln Asn Leu Glu Cys Val Glu 
305                 310                 315                 320 


Val Ile Ser Glu Lys Arg Leu Gln Gly Glu Glu Ser Val Val Leu Ile 
                325                 330                 335     


Pro Lys Ser Leu His His Val Pro Asp Ser Ala Ser Gly Met Thr Pro 
            340                 345                 350         


Gly Leu Gly His Arg Val Pro Glu Ser Val Glu Leu Thr Ser Lys Ser 
        355                 360                 365             


Gly Val Gln Val Glu Lys Thr Leu Gln Leu Thr Pro Lys Pro Gln His 
    370                 375                 380                 


His Val Gly Ser Pro Gly Ile Ile Ser Gly Leu Gly His Gln Val Pro 
385                 390                 395                 400 


Glu Ser Val Asn Leu Thr Cys Lys Gln Trp Leu Gln Met Glu Glu Ser 
                405                 410                 415     


Leu Glu Val Pro Leu Lys Gln Thr Ser Gln Val Ile Gly His Glu Glu 
            420                 425                 430         


Ser Val Glu Leu Thr Ser Glu Ala Arg Gln His Arg Glu Val Ser Met 
        435                 440                 445             


Gly Leu Thr Lys Ser Lys Asn Gln Ser Met Lys Ser Pro Gly Thr Thr 
    450                 455                 460                 


Pro Gly Pro Leu Gly Arg Ile Val Glu Phe Met Arg Ile Ser Pro Glu 
465                 470                 475                 480 


Pro Leu Asp Gln Val Thr Glu Ser Ala Arg Thr Gln Leu Gln Val Ala 
                485                 490                 495     


Gln Ser Glu Glu Val Ile Leu Ile Asp Val Pro Lys Val Val Gln Ser 
            500                 505                 510         


Val Lys Val Thr Pro Gly Pro Pro Phe Gln Ile Val Lys Ser Val Thr 
        515                 520                 525             


Ile Pro Arg Pro Thr Pro Gln Met Val Glu Tyr Ile Glu Leu Thr Pro 
    530                 535                 540                 


Lys Leu Gln Tyr Val Arg Pro Ser Glu His His Thr Gly Pro Cys Leu 
545                 550                 555                 560 


Gln Asp Val Lys Ser Thr Lys Leu Ile Thr Lys Pro Lys His Gln Ile 
                565                 570                 575     


Leu Glu Thr Val Glu Leu Thr Gly Phe Gln Ile Val Lys Thr Met Leu 
            580                 585                 590         


Ile Pro Gly Pro Ser Leu Gln Ile Val Lys Ser Glu Glu Leu Ala Pro 
        595                 600                 605             


Gly Pro Ile Pro Gln Val Val Glu Pro Ile Gly Val Ala Leu Glu Ser 
    610                 615                 620                 


Gly Ile Glu Ala Ile Asn Cys Val Asp Leu Leu Pro Arg Pro His Leu 
625                 630                 635                 640 


Gln Glu Leu Ile Val Pro Ala Glu Leu Thr Pro Ser Pro Cys Thr Gln 
                645                 650                 655     


Val Lys Ser Ala Glu Leu Thr Ser Pro Gln Thr Ser Pro Phe Glu Glu 
            660                 665                 670         


His Thr Ile Leu Thr His Lys Gln Gly Leu Gln Ala Val Lys Ser Thr 
        675                 680                 685             


Val Ile Lys Thr Glu Pro Pro Lys Val Met Glu Thr Glu Asp Leu Asn 
    690                 695                 700                 


Leu Gly His Val Cys Gln Asn Arg Asp Cys Gln Lys Leu Thr Ser Glu 
705                 710                 715                 720 


Glu Leu Gln Val Gly Thr Asp Phe Ser Arg Phe Leu Gln Ser Ser Ser 
                725                 730                 735     


Thr Thr Leu Ile Ser Ser Ser Val Arg Thr Ala Ser Glu Leu Gly Gly 
            740                 745                 750         


Leu Trp Asp Ser Gly Ile Gln Glu Val Ser Arg Ala Leu Asp Ile Lys 
        755                 760                 765             


Asn Pro Gly Thr Asp Ile Leu Gln Pro Glu Glu Thr Tyr Ile Asp Pro 
    770                 775                 780                 


Thr Met Ile Gln Ser Leu Thr Phe Pro Leu Ala Leu His Asn Gln Ser 
785                 790                 795                 800 


Ser Asp Lys Thr Ala Asn Ile Val Glu Asn Pro Cys Pro Glu Ile Leu 
                805                 810                 815     


Gly Val Asp Val Ile Ser Lys Glu Thr Thr Lys Arg Lys Gln Met Glu 
            820                 825                 830         


Glu Leu Glu Asn Ser Leu Gln Arg His Leu Pro Gln Ser Trp Arg Ser 
        835                 840                 845             


Arg Ser Arg Thr Phe Gln Ala Glu Ser Gly Val Gln Lys Gly Leu Ile 
    850                 855                 860                 


Lys Ser Phe Pro Gly Arg Gln His Asn Val Trp Glu Ser His Ala Trp 
865                 870                 875                 880 


Arg Gln Arg Leu Pro Arg Lys Tyr Leu Ser Thr Met Leu Met Leu Gly 
                885                 890                 895     


Asn Ile Leu Gly Thr Thr Met Glu Arg Lys Leu Cys Ser Gln Thr Ser 
            900                 905                 910         


Leu Ala Glu Arg Ala Thr Ala Asp Thr Cys Gln Ser Ile Gln Asn Leu 
        915                 920                 925             


Phe Gly Ile Pro Ala Glu Leu Met Glu Pro Ser Gln Ser Leu Pro Glu 
    930                 935                 940                 


Lys Gly Pro Val Thr Ile Ser Gln Pro Ser Val Val Lys Asn Tyr Ile 
945                 950                 955                 960 


Gln Arg His Thr Phe Tyr His Gly His Lys Lys Arg Met Ala Leu Arg 
                965                 970                 975     


Ile Trp Thr Arg Gly Ser Thr Ser Ser Ile Ile Gln Gln Tyr Ser Gly 
            980                 985                 990         


Thr Arg Val Arg Ile Lys Lys Thr  Asn Ser Thr Phe Asn  Gly Ile Ser 
        995                 1000                 1005             


Gln Glu  Val Ile Gln His Met  Pro Val Ser Cys Ala  Gly Gly Gln 
    1010                 1015                 1020             


Leu Pro  Val Leu Val Lys Ser  Glu Ser Ser Leu Ser  Ile Phe Tyr 
    1025                 1030                 1035             


Asp Arg  Glu Asp Leu Val Pro  Met Glu Glu Ser Glu  Asp Ser Gln 
    1040                 1045                 1050             


Ser Asp  Ser Gln Thr Arg Ile  Ser Glu Ser Gln His  Ser Leu Lys 
    1055                 1060                 1065             


Pro Asn  Tyr Leu Ser Gln Ala  Lys Thr Asp Phe Ser  Glu Gln Phe 
    1070                 1075                 1080             


Gln Leu  Leu Glu Asp Leu Gln  Leu Lys Ile Ala Ala  Lys Leu Leu 
    1085                 1090                 1095             


Arg Ser  Gln Ile Pro Pro Asp  Val Pro Pro Pro Leu  Ala Ser Gly 
    1100                 1105                 1110             


Leu Val  Leu Lys Tyr Pro Ile  Cys Leu Gln Cys Gly  Arg Cys Ser 
    1115                 1120                 1125             


Gly Leu  Asn Cys His His Lys  Leu Gln Thr Thr Ser  Gly Pro Tyr 
    1130                 1135                 1140             


Leu Leu  Ile Tyr Pro Gln Leu  His Leu Val Arg Thr  Pro Glu Gly 
    1145                 1150                 1155             


His Gly  Glu Val Arg Leu His  Leu Gly Phe Arg Leu  Arg Ile Gly 
    1160                 1165                 1170             


Lys Arg  Ser Gln Ile Ser Lys  Tyr Arg Glu Arg Asp  Arg Pro Val 
    1175                 1180                 1185             


Ile Arg  Arg Ser Pro Ile Ser  Pro Ser Gln Arg Lys  Ala Lys Ile 
    1190                 1195                 1200             


Tyr Thr  Gln Ala Ser Lys Ser  Pro Thr Ser Thr Ile  Asp Leu Gln 
    1205                 1210                 1215             


Ser Gly  Pro Ser Gln Ser Pro  Ala Pro Val Gln Val  Tyr Ile Arg 
    1220                 1225                 1230             


Arg Gly  Gln Arg Ser Arg Pro  Asp Leu Val Glu Lys  Thr Lys Thr 
    1235                 1240                 1245             


Arg Ala  Pro Gly His Tyr Glu  Phe Thr Gln Val His  Asn Leu Pro 
    1250                 1255                 1260             


Glu Ser  Asp Ser Glu Ser Thr  Gln Asn Glu Lys Arg  Ala Lys Val 
    1265                 1270                 1275             


Arg Thr  Lys Lys Thr Ser Asp  Ser Lys Tyr Pro Met  Lys Arg Ile 
    1280                 1285                 1290             


Thr Lys  Arg Leu Arg Lys His  Arg Lys Phe Tyr Thr  Asn Ser Arg 
    1295                 1300                 1305             


Thr Thr  Ile Glu Ser Pro Ser  Arg Glu Leu Ala Ala  His Leu Arg 
    1310                 1315                 1320             


Arg Lys  Arg Ile Gly Ala Thr  Gln Thr Ser Thr Ala  Ser Leu Lys 
    1325                 1330                 1335             


Arg Gln  Pro Lys Lys Pro Ser  Gln Pro Lys Phe Met  Gln Leu Leu 
    1340                 1345                 1350             


Phe Gln  Ser Leu Lys Arg Ala  Phe Gln Thr Ala His  Arg Val Ile 
    1355                 1360                 1365             


Ala Ser  Val Gly Arg Lys Pro  Val Asp Gly Thr Arg  Pro Asp Asn 
    1370                 1375                 1380             


Leu Trp  Ala Ser Lys Asn Tyr  Tyr Pro Lys Gln Asn  Ala Arg Asp 
    1385                 1390                 1395             


Tyr Cys  Leu Pro Ser Ser Ile  Lys Arg Asp Lys Arg  Ser Ala Asp 
    1400                 1405                 1410             


Lys Leu  Thr Pro Ala Gly Ser  Thr Ile Lys Gln Glu  Asp Ile Leu 
    1415                 1420                 1425             


Trp Gly  Gly Thr Val Gln Cys  Arg Ser Ala Gln Gln  Pro Arg Arg 
    1430                 1435                 1440             


Ala Tyr  Ser Phe Gln Pro Arg  Pro Leu Arg Leu Pro  Lys Pro Thr 
    1445                 1450                 1455             


Asp Ser  Gln Ser Gly Ile Ala  Phe Gln Thr Ala Ser  Val Gly Gln 
    1460                 1465                 1470             


Pro Leu  Arg Thr Val Gln Lys  Asp Ser Ser Ser Arg  Ser Lys Lys 
    1475                 1480                 1485             


Asn Phe  Tyr Arg Asn Glu Thr  Ser Ser Gln Glu Ser  Lys Asn Leu 
    1490                 1495                 1500             


Ser Thr  Pro Gly Thr Arg Val  Gln Ala Arg Gly Arg  Ile Leu Pro 
    1505                 1510                 1515             


Gly Ser  Pro Val Lys Arg Thr  Trp His Arg His Leu  Lys Asp Lys 
    1520                 1525                 1530             


Leu Thr  His Lys Glu His Asn  His Pro Ser Phe Tyr  Arg Glu Arg 
    1535                 1540                 1545             


Thr Pro  Arg Gly Pro Ser Glu  Arg Thr Arg His Asn  Pro Ser Trp 
    1550                 1555                 1560             


Arg Asn  His Arg Ser Pro Ser  Glu Arg Ser Gln Arg  Ser Ser Leu 
    1565                 1570                 1575             


Glu Arg  Arg His His Ser Pro  Ser Gln Arg Ser His  Cys Ser Pro 
    1580                 1585                 1590             


Ser Arg  Lys Asn His Ser Ser  Pro Ser Glu Arg Ser  Trp Arg Ser 
    1595                 1600                 1605             


Pro Ser  Gln Arg Asn His Cys  Ser Pro Pro Glu Arg  Ser Cys His 
    1610                 1615                 1620             


Ser Leu  Ser Glu Arg Gly Leu  His Ser Pro Ser Gln  Arg Ser His 
    1625                 1630                 1635             


Arg Gly  Pro Ser Gln Arg Arg  His His Ser Pro Ser  Glu Arg Ser 
    1640                 1645                 1650             


His Arg  Ser Pro Ser Glu Arg  Ser His Arg Ser Ser  Ser Glu Arg 
    1655                 1660                 1665             


Arg His  Arg Ser Pro Ser Gln  Arg Ser His Arg Gly  Pro Ser Glu 
    1670                 1675                 1680             


Arg Ser  His Cys Ser Pro Ser  Glu Arg Arg His Arg  Ser Pro Ser 
    1685                 1690                 1695             


Gln Arg  Ser His Arg Gly Pro  Ser Glu Arg Arg His  His Ser Pro 
    1700                 1705                 1710             


Ser Lys  Arg Ser His Arg Ser  Pro Ala Arg Arg Ser  His Arg Ser 
    1715                 1720                 1725             


Pro Ser  Glu Arg Ser His His  Ser Pro Ser Glu Arg  Ser His His 
    1730                 1735                 1740             


Ser Pro  Ser Glu Arg Arg His  His Ser Pro Ser Glu  Arg Ser His 
    1745                 1750                 1755             


Cys Ser  Pro Ser Glu Arg Ser  His Cys Ser Pro Ser  Glu Arg Arg 
    1760                 1765                 1770             


His Arg  Ser Pro Ser Glu Arg  Arg His His Ser Pro  Ser Glu Lys 
    1775                 1780                 1785             


Ser His  His Ser Pro Ser Glu  Arg Ser His His Ser  Pro Ser Glu 
    1790                 1795                 1800             


Arg Arg  Arg His Ser Pro Leu  Glu Arg Ser Arg His  Ser Leu Leu 
    1805                 1810                 1815             


Glu Arg  Ser His Arg Ser Pro  Ser Glu Arg Arg Ser  His Arg Ser 
    1820                 1825                 1830             


Phe Glu  Arg Ser His Arg Arg  Ile Ser Glu Arg Ser  His Ser Pro 
    1835                 1840                 1845             


Ser Glu  Lys Ser His Leu Ser  Pro Leu Glu Arg Ser  Arg Cys Ser 
    1850                 1855                 1860             


Pro Ser  Glu Arg Arg Gly His  Ser Ser Ser Gly Lys  Thr Cys His 
    1865                 1870                 1875             


Ser Pro  Ser Glu Arg Ser His  Arg Ser Pro Ser Gly  Met Arg Gln 
    1880                 1885                 1890             


Gly Arg  Thr Ser Glu Arg Ser  His Arg Ser Ser Cys  Glu Arg Thr 
    1895                 1900                 1905             


Arg His  Ser Pro Ser Glu Met  Arg Pro Gly Arg Pro  Ser Gly Arg 
    1910                 1915                 1920             


Asn His  Cys Ser Pro Ser Glu  Arg Ser Arg Arg Ser  Pro Leu Lys 
    1925                 1930                 1935             


Glu Gly  Leu Lys Tyr Ser Phe  Pro Gly Glu Arg Pro  Ser His Ser 
    1940                 1945                 1950             


Leu Ser  Arg Asp Phe Lys Asn  Gln Thr Thr Leu Leu  Gly Thr Thr 
    1955                 1960                 1965             


His Lys  Asn Pro Lys Ala Gly  Gln Val Trp Arg Pro  Glu Ala Thr 
    1970                 1975                 1980             


Arg 
    


<210>  1400
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2orf40__Homo_sapiens__NP_115787

<400>  1400

Met Ala Ala Ser Pro Ala Arg Pro Ala Val Leu Ala Leu Thr Gly Leu 
1               5                   10                  15      


Ala Leu Leu Leu Leu Leu Cys Trp Gly Pro Gly Gly Ile Ser Gly Asn 
            20                  25                  30          


Lys Leu Lys Leu Met Leu Gln Lys Arg Glu Ala Pro Val Pro Thr Lys 
        35                  40                  45              


Thr Lys Val Ala Val Asp Glu Asn Lys Ala Lys Glu Phe Leu Gly Ser 
    50                  55                  60                  


Leu Lys Arg Gln Lys Arg Gln Leu Trp Asp Arg Thr Arg Pro Glu Val 
65                  70                  75                  80  


Gln Gln Trp Tyr Gln Gln Phe Leu Tyr Met Gly Phe Asp Glu Ala Lys 
                85                  90                  95      


Phe Glu Asp Asp Ile Thr Tyr Trp Leu Asn Arg Asp Arg Asn Gly His 
            100                 105                 110         


Glu Tyr Tyr Gly Asp Tyr Tyr Gln Arg His Tyr Asp Glu Asp Ser Ala 
        115                 120                 125             


Ile Gly Pro Arg Ser Pro Tyr Gly Phe Arg His Gly Ala Ser Val Asn 
    130                 135                 140                 


Tyr Asp Asp Tyr 
145             


<210>  1401
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2orf43__Homo_sapiens__NP_001269649

<400>  1401

Met Asp Ser Glu Leu Lys Glu Glu Ile Pro Val His Glu Glu Phe Ile 
1               5                   10                  15      


Leu Cys Gly Gly Ala Glu Thr Gln Val Leu Lys Cys Gly Pro Trp Thr 
            20                  25                  30          


Asp Leu Phe His Asp Gln Ser Val Lys Arg Pro Lys Leu Leu Ile Phe 
        35                  40                  45              


Ile Ile Pro Asp Ser Asn Ala Gln Glu Ile Lys Asp Ile Tyr Gly Leu 
    50                  55                  60                  


Asn Gly Gln Ile Glu His Lys Leu Ala Phe Leu Arg Thr His Val Pro 
65                  70                  75                  80  


Lys Asp Met Lys Leu Val Leu Ile Gly His Ser Ile Gly Ser Tyr Phe 
                85                  90                  95      


Thr Leu Gln Met Leu Lys Arg Val Pro Glu Leu Pro Val Ile Arg Ala 
            100                 105                 110         


Phe Leu Leu Phe Pro Thr Ile Glu Arg Met Ser Glu Ser Pro Asn Gly 
        115                 120                 125             


Arg Ile Ala Thr Pro Leu Leu Cys Trp Phe Arg Tyr Val Leu Tyr Val 
    130                 135                 140                 


Thr Gly Tyr Leu Leu Leu Lys Pro Cys Pro Glu Thr Ile Lys Ser Leu 
145                 150                 155                 160 


Leu Ile Arg Arg Gly Leu Gln Val Met Asn Leu Glu Asn Glu Phe Ser 
                165                 170                 175     


Pro Leu Asn Ile Leu Glu Pro Phe Cys Leu Ala Asn Ala Ala Tyr Leu 
            180                 185                 190         


Gly Gly Gln Glu Met Met Glu Val Val Lys Arg Asp Asp Glu Thr Ile 
        195                 200                 205             


Lys Glu His Leu Cys Lys Leu Thr Phe Tyr Tyr Gly Thr Ile Asp Pro 
    210                 215                 220                 


Trp Cys Pro Lys Glu Tyr Tyr Glu Asp Ile Lys Lys Asp Phe Pro Glu 
225                 230                 235                 240 


Gly Asp Ile Arg Leu Cys Glu Lys Asn Ile Pro His Ala Phe Ile Thr 
                245                 250                 255     


His Phe Asn Gln Glu Met Ala Asp Met Ile Ala Asp Ser Leu Lys Asp 
            260                 265                 270         


Asp Leu Ser Lys Met 
        275         


<210>  1402
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2orf47__Homo_sapiens__NP_078796

<400>  1402

Met Ala Leu Ala Ala Arg Leu Leu Pro Gln Phe Leu His Ser Arg Ser 
1               5                   10                  15      


Leu Pro Cys Gly Ala Val Arg Leu Arg Thr Pro Ala Val Ala Glu Val 
            20                  25                  30          


Arg Leu Pro Ser Ala Thr Leu Cys Tyr Phe Cys Arg Cys Arg Leu Gly 
        35                  40                  45              


Leu Gly Ala Ala Leu Phe Pro Arg Ser Ala Arg Ala Leu Ala Ala Ser 
    50                  55                  60                  


Ala Leu Pro Ala Gln Gly Ser Arg Trp Pro Val Leu Ser Ser Pro Gly 
65                  70                  75                  80  


Leu Pro Ala Ala Phe Ala Ser Phe Pro Ala Cys Pro Gln Arg Ser Tyr 
                85                  90                  95      


Ser Thr Glu Glu Lys Pro Gln Gln His Gln Lys Thr Lys Met Ile Val 
            100                 105                 110         


Leu Gly Phe Ser Asn Pro Ile Asn Trp Val Arg Thr Arg Ile Lys Ala 
        115                 120                 125             


Phe Leu Ile Trp Ala Tyr Phe Asp Lys Glu Phe Ser Ile Thr Glu Phe 
    130                 135                 140                 


Ser Glu Gly Ala Lys Gln Ala Phe Ala His Val Ser Lys Leu Leu Ser 
145                 150                 155                 160 


Gln Cys Lys Phe Asp Leu Leu Glu Glu Leu Val Ala Lys Glu Val Leu 
                165                 170                 175     


His Ala Leu Lys Glu Lys Val Thr Ser Leu Pro Asp Asn His Lys Asn 
            180                 185                 190         


Ala Leu Ala Ala Asn Ile Asp Glu Ile Val Phe Thr Ser Thr Gly Asp 
        195                 200                 205             


Ile Ser Ile Tyr Tyr Asp Glu Lys Gly Arg Lys Phe Val Asn Ile Leu 
    210                 215                 220                 


Met Cys Phe Trp Tyr Leu Thr Ser Ala Asn Ile Pro Ser Glu Thr Leu 
225                 230                 235                 240 


Arg Gly Ala Ser Val Phe Gln Val Lys Leu Gly Asn Gln Asn Val Glu 
                245                 250                 255     


Thr Lys Gln Leu Leu Ser Ala Ser Tyr Glu Phe Gln Arg Glu Phe Thr 
            260                 265                 270         


Gln Gly Val Lys Pro Asp Trp Thr Ile Ala Arg Ile Glu His Ser Lys 
        275                 280                 285             


Leu Leu Glu 
    290     


<210>  1403
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2orf57__Homo_sapiens__NP_689827

<400>  1403

Met Ala Leu Pro Gly Tyr Pro Leu Gly Asn Val Asp Asp Ser Arg Ser 
1               5                   10                  15      


Lys Asp Ser Pro Ala Gly Glu Pro Gln Gly Gln Val Pro Leu Thr Ala 
            20                  25                  30          


Asp Val Leu Ala Val Ser Ser Ser Val Ala Ser Thr Asp Trp Gln Asp 
        35                  40                  45              


Ile Asp Gln Ala Ser Phe Lys Thr Ala Thr Pro Arg Ala Ile Ser Thr 
    50                  55                  60                  


Ser Gly Asp Lys Asp Lys Ser Ala Val Val Pro Glu His Gly Gln Lys 
65                  70                  75                  80  


Thr Pro Arg Lys Ile Thr Pro Leu Leu Pro Ser Gln Asn Pro Ser Pro 
                85                  90                  95      


Leu Gln Val Ser Met Ser Leu Gln Asn Pro Ala Trp Asp Arg Gln Val 
            100                 105                 110         


Gln Asp Ala Arg Thr Ser Gln Ser Leu Val Val Phe Pro Ser His Leu 
        115                 120                 125             


Leu Gly Lys Asp Lys Met Ser Gln Met Ala Ser Val Pro Glu Arg Glu 
    130                 135                 140                 


Pro Glu Ser Ala Pro Ser Ala Pro Ser Ala Glu Leu Gln Ser Thr Gln 
145                 150                 155                 160 


His Met Glu Ala Gln Pro Val Glu Ser Asp Ala Asp His Val Thr Ala 
                165                 170                 175     


Gly Ala Asn Gly Gln His Gly Pro Gln Ala Ala Ser Thr Thr Lys Ser 
            180                 185                 190         


Ala Glu Glu Lys Ala Glu His Pro Lys Ala Pro His Pro Glu Ala Glu 
        195                 200                 205             


Ala Leu Pro Ser Asp Glu Ser Pro Val Ala Met Gly Ala Asn Val Val 
    210                 215                 220                 


Asp Ser Leu Gly Asp Leu Gln Thr Trp Phe Phe Pro Pro Pro Pro Ala 
225                 230                 235                 240 


Gly Ser Val Ser Pro Ser Pro Gly Pro His Glu Val Ala Leu Gly Arg 
                245                 250                 255     


Arg Pro Leu Asp Ser Ser Leu Tyr Thr Ala Ser Glu Glu Asn Ser Tyr 
            260                 265                 270         


Met Arg Ser Met Thr Ser Leu Leu Asp Arg Gly Glu Gly Ser Ile Ser 
        275                 280                 285             


Ser Leu Ala Asp Ile Leu Val Trp Ser Glu Thr Thr Met Gly Met Ala 
    290                 295                 300                 


Ile Ala Thr Gly Phe Leu Asp Ser Gly His Ser Thr Val Ala Asp Leu 
305                 310                 315                 320 


Leu His Ser Ser Gly Pro Ser Leu Arg Ser Val Pro Ser Leu Val Gly 
                325                 330                 335     


Ser Val Ser Ser Ala Phe Ser Ser Gly Leu Val Ser Gly Thr Ser Ser 
            340                 345                 350         


Ala Leu Arg Thr Ile Thr Arg Val Leu Glu Thr Val Glu Gln Arg Thr 
        355                 360                 365             


Val Glu Gly Ile Arg Ser Ala Met Arg Tyr Leu Thr Ser His Leu Thr 
    370                 375                 380                 


Pro Arg Gln Ala Gln Ala Asp Pro Asn Tyr Asp 
385                 390                 395 


<210>  1404
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2orf61__Homo_sapiens__NP_001157033

<400>  1404

Met Asp Gln Pro Ala Val Ala Thr Ala Ser Thr Ser Ile Arg Glu Asp 
1               5                   10                  15      


Leu Val Gly Gly Glu Ser Phe Ile Thr Ala Ser Lys Pro Ala Gln Lys 
            20                  25                  30          


Thr Ser Ser Phe Glu Arg Glu Gly Trp Trp Arg Ile Ala Leu Thr Asp 
        35                  40                  45              


Thr Pro Ile Pro Gly Thr Tyr His Leu Lys Thr Phe Ile Glu Glu Ser 
    50                  55                  60                  


Leu Leu Asn Pro Val Ile Ala Thr Tyr Asn Phe Lys Asn Glu Gly Arg 
65                  70                  75                  80  


Lys Lys Pro Pro Leu Val Gln Arg Asn Asn Pro Val Leu Asn Asp Leu 
                85                  90                  95      


Pro Gln Tyr Met Pro Pro Asp Phe Leu Asp Leu Leu Lys Lys Gln Val 
            100                 105                 110         


Ala Thr Tyr Ser Phe Lys Asp Lys Pro Arg Pro Ser Pro Ser Thr Leu 
        115                 120                 125             


Val Asp Lys Asp Gln Ser Leu Gln Leu Ser Pro Gly Gln Tyr Asn Val 
    130                 135                 140                 


Leu Pro Ala Pro Val Pro Lys Tyr Ala Ser Arg Ser Cys Val Phe Arg 
145                 150                 155                 160 


Ser Thr Val Gln Arg Phe Pro Thr Thr Tyr Phe Ile Pro His Glu Gly 
                165                 170                 175     


Pro Gly Pro Gly His Tyr Asn Val Lys Met Pro Pro Thr Ser Ser Val 
            180                 185                 190         


Thr Ser Cys Phe Gln Ser Arg Val Pro Arg Phe Leu Pro Ser Cys Ser 
        195                 200                 205             


Lys Thr Pro Gly Pro Gly Ala Tyr Thr Thr Leu Arg Gln Phe Pro Lys 
    210                 215                 220                 


Gln Ser Pro Thr Ile Ala Lys Met Gly Gln Glu His Ser Leu Phe Phe 
225                 230                 235                 240 


Asn Asn Asn Asn Trp Leu Leu Lys 
                245             


<210>  1405
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3AR1__Homo_sapiens__NP_004045

<400>  1405

Met Ala Ser Phe Ser Ala Glu Thr Asn Ser Thr Asp Leu Leu Ser Gln 
1               5                   10                  15      


Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 
            20                  25                  30          


Thr Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 
        35                  40                  45              


Gly Leu Lys Met Gln Arg Thr Val Asn Thr Ile Trp Phe Leu His Leu 
    50                  55                  60                  


Thr Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 
65                  70                  75                  80  


His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 
                85                  90                  95      


Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 
            100                 105                 110         


Leu Thr Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 
        115                 120                 125             


Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 
    130                 135                 140                 


Cys Ile Trp Val Val Ala Phe Val Met Cys Ile Pro Val Phe Val Tyr 
145                 150                 155                 160 


Arg Glu Ile Phe Thr Thr Asp Asn His Asn Arg Cys Gly Tyr Lys Phe 
                165                 170                 175     


Gly Leu Ser Ser Ser Leu Asp Tyr Pro Asp Phe Tyr Gly Asp Pro Leu 
            180                 185                 190         


Glu Asn Arg Ser Leu Glu Asn Ile Val Gln Pro Pro Gly Glu Met Asn 
        195                 200                 205             


Asp Arg Leu Asp Pro Ser Ser Phe Gln Thr Asn Asp His Pro Trp Thr 
    210                 215                 220                 


Val Pro Thr Val Phe Gln Pro Gln Thr Phe Gln Arg Pro Ser Ala Asp 
225                 230                 235                 240 


Ser Leu Pro Arg Gly Ser Ala Arg Leu Thr Ser Gln Asn Leu Tyr Ser 
                245                 250                 255     


Asn Val Phe Lys Pro Ala Asp Val Val Ser Pro Lys Ile Pro Ser Gly 
            260                 265                 270         


Phe Pro Ile Glu Asp His Glu Thr Ser Pro Leu Asp Asn Ser Asp Ala 
        275                 280                 285             


Phe Leu Ser Thr His Leu Lys Leu Phe Pro Ser Ala Ser Ser Asn Ser 
    290                 295                 300                 


Phe Tyr Glu Ser Glu Leu Pro Gln Gly Phe Gln Asp Tyr Tyr Asn Leu 
305                 310                 315                 320 


Gly Gln Phe Thr Asp Asp Asp Gln Val Pro Thr Pro Leu Val Ala Ile 
                325                 330                 335     


Thr Ile Thr Arg Leu Val Val Gly Phe Leu Leu Pro Ser Val Ile Met 
            340                 345                 350         


Ile Ala Cys Tyr Ser Phe Ile Val Phe Arg Met Gln Arg Gly Arg Phe 
        355                 360                 365             


Ala Lys Ser Gln Ser Lys Thr Phe Arg Val Ala Val Val Val Val Ala 
    370                 375                 380                 


Val Phe Leu Val Cys Trp Thr Pro Tyr His Ile Phe Gly Val Leu Ser 
385                 390                 395                 400 


Leu Leu Thr Asp Pro Glu Thr Pro Leu Gly Lys Thr Leu Met Ser Trp 
                405                 410                 415     


Asp His Val Cys Ile Ala Leu Ala Ser Ala Asn Ser Cys Phe Asn Pro 
            420                 425                 430         


Phe Leu Tyr Ala Leu Leu Gly Lys Asp Phe Arg Lys Lys Ala Arg Gln 
        435                 440                 445             


Ser Ile Gln Gly Ile Leu Glu Ala Ala Phe Ser Glu Glu Leu Thr Arg 
    450                 455                 460                 


Ser Thr His Cys Pro Ser Asn Asn Val Ile Ser Glu Arg Asn Ser Thr 
465                 470                 475                 480 


Thr Val 
        


<210>  1406
<211>  1663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3__Homo_sapiens__NP_000055

<400>  1406

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  1407
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf17__Homo_sapiens__NP_056227

<400>  1407

Met Met Ala Ala Val Pro Pro Gly Leu Glu Pro Trp Asn Arg Val Arg 
1               5                   10                  15      


Ile Pro Lys Ala Gly Asn Arg Ser Ala Val Thr Val Gln Asn Pro Gly 
            20                  25                  30          


Ala Ala Leu Asp Leu Cys Ile Ala Ala Val Ile Lys Glu Cys His Leu 
        35                  40                  45              


Val Ile Leu Ser Leu Lys Ser Gln Thr Leu Asp Ala Glu Thr Asp Val 
    50                  55                  60                  


Leu Cys Ala Val Leu Tyr Ser Asn His Asn Arg Met Gly Arg His Lys 
65                  70                  75                  80  


Pro His Leu Ala Leu Lys Gln Val Glu Gln Cys Leu Lys Arg Leu Lys 
                85                  90                  95      


Asn Met Asn Leu Glu Gly Ser Ile Gln Asp Leu Phe Glu Leu Phe Ser 
            100                 105                 110         


Ser Asn Glu Asn Gln Pro Leu Thr Thr Lys Val Cys Val Val Pro Ser 
        115                 120                 125             


Gln Pro Val Val Glu Leu Val Leu Met Lys Val Leu Gly Ala Cys Lys 
    130                 135                 140                 


Leu Leu Leu Arg Leu Leu Asp Cys Cys Cys Lys Thr Phe Leu Leu Thr 
145                 150                 155                 160 


Val Lys His Leu Gly Leu Gln Glu Phe Ile Ile Leu Asn Leu Val Met 
                165                 170                 175     


Val Gly Leu Val Ser Arg Leu Trp Val Leu Tyr Lys Gly Val Leu Lys 
            180                 185                 190         


Arg Leu Ile Leu Leu Tyr Glu Pro Leu Phe Gly Leu Leu Gln Glu Val 
        195                 200                 205             


Ala Arg Ile Gln Pro Met Pro Tyr Phe Lys Asp Phe Thr Phe Pro Ser 
    210                 215                 220                 


Asp Ile Thr Glu Phe Leu Gly Gln Pro Tyr Phe Glu Ala Phe Lys Lys 
225                 230                 235                 240 


Lys Met Pro Ile Ala Phe Ala Ala Lys Gly Ile Asn Lys Leu Leu Asn 
                245                 250                 255     


Lys Leu Phe Leu Ile Asn Glu Gln Ser Pro Arg Ala Ser Glu Glu Thr 
            260                 265                 270         


Leu Leu Gly Ile Ser Lys Lys Ala Lys Gln Met Lys Ile Asn Val Gln 
        275                 280                 285             


Asn Asn Val Asp Leu Gly Gln Pro Val Lys Asn Lys Arg Val Phe Lys 
    290                 295                 300                 


Glu Glu Ser Ser Glu Phe Asp Val Arg Ala Phe Cys Asn Gln Leu Lys 
305                 310                 315                 320 


His Lys Ala Thr Gln Glu Thr Ser Phe Asp Phe Lys Cys Ser Gln Ser 
                325                 330                 335     


Arg Leu Lys Thr Thr Lys Tyr Ser Ser Gln Lys Val Ile Gly Thr Pro 
            340                 345                 350         


His Ala Lys Ser Phe Val Gln Arg Phe Arg Glu Ala Glu Ser Phe Thr 
        355                 360                 365             


Gln Leu Ser Glu Glu Ile Gln Met Ala Val Val Trp Cys Arg Ser Lys 
    370                 375                 380                 


Lys Leu Lys Ala Gln Ala Ile Phe Leu Gly Asn Lys Leu Leu Lys Ser 
385                 390                 395                 400 


Asn Arg Leu Lys His Leu Glu Ala Gln Gly Thr Ser Leu Pro Lys Lys 
                405                 410                 415     


Leu Glu Cys Ile Lys Thr Ser Ile Cys Asn His Leu Leu Arg Gly Ser 
            420                 425                 430         


Gly Ile Lys Thr Ser Lys His His Leu Arg Gln Arg Arg Ser Gln Asn 
        435                 440                 445             


Lys Phe Leu Arg Arg Gln Arg Lys Pro Gln Arg Lys Leu Gln Ser Thr 
    450                 455                 460                 


Leu Leu Arg Glu Ile Gln Gln Phe Ser Gln Gly Thr Arg Lys Ser Ala 
465                 470                 475                 480 


Thr Asp Thr Ser Ala Lys Trp Arg Leu Ser His Cys Thr Val His Arg 
                485                 490                 495     


Thr Asp Leu Tyr Pro Asn Ser Lys Gln Leu Leu Asn Ser Gly Val Ser 
            500                 505                 510         


Met Pro Val Ile Gln Thr Lys Glu Lys Met Ile His Glu Asn Leu Arg 
        515                 520                 525             


Gly Ile His Glu Asn Glu Thr Asp Ser Trp Thr Val Met Gln Ile Asn 
    530                 535                 540                 


Lys Asn Ser Thr Ser Gly Thr Ile Lys Glu Thr Asp Asp Ile Asp Asp 
545                 550                 555                 560 


Ile Phe Ala Leu Met Gly Val 
                565         


<210>  1408
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf18__Homo_sapiens__NP_001165212

<400>  1408

Met Asn Ser Arg Thr Ala Ser Ala Arg Gly Trp Phe Ser Ser Arg Pro 
1               5                   10                  15      


Pro Thr Ser Glu Ser Asp Leu Glu Pro Ala Thr Asp Gly Pro Ala Ser 
            20                  25                  30          


Glu Thr Thr Thr Leu Ser Pro Glu Ala Thr Thr Phe Asn Asp Thr Arg 
        35                  40                  45              


Ile Pro Asp Ala Ala Gly Gly Thr Ala Gly Val Gly Thr Met Leu Leu 
    50                  55                  60                  


Ser Phe Gly Ile Ile Thr Val Ile Gly Leu Ala Val Ala Leu Val Leu 
65                  70                  75                  80  


Tyr Ile Arg Lys Lys Lys Arg Leu Glu Lys Leu Arg His Gln Leu Met 
                85                  90                  95      


Pro Met Tyr Asn Phe Asp Pro Thr Glu Glu Gln Asp Glu Leu Glu Gln 
            100                 105                 110         


Glu Leu Leu Glu His Gly Arg Asp Ala Ala Ser Val Gln Ala Ala Thr 
        115                 120                 125             


Ser Val Gln Ala Met Gln Gly Lys Thr Thr Leu Pro Ser Gln Gly Pro 
    130                 135                 140                 


Leu Gln Arg Pro Ser Arg Leu Val Phe Thr Asp Val Ala Asn Ala Ile 
145                 150                 155                 160 


His Ala 
        


<210>  1409
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf20__Homo_sapiens__NP_001171887

<400>  1409

Met Ala Arg Gln Val Arg Thr His Gln Glu Thr Leu Asn Arg Phe Gln 
1               5                   10                  15      


Gln Gln Ser Ile His Leu Leu Thr Glu Leu Leu Arg Leu Lys Met Lys 
            20                  25                  30          


Ala Met Val Glu Ser Met Ser Val Gly Ala Asn Pro Leu Asp Ile Thr 
        35                  40                  45              


Arg Arg Phe Val Glu Ala Ser Gln Leu Leu His Leu Asn Ala Lys Glu 
    50                  55                  60                  


Met Ala Phe Asn Cys Leu Ile Ser Thr Ala Gly Arg Ser Gly Tyr Ser 
65                  70                  75                  80  


Ser Gly Gln Leu Trp Lys Glu Ser Leu Ala Asn Met Ser Ala Ile Gly 
                85                  90                  95      


Val Asn Ser Pro Tyr Gln Leu Ile Tyr His Ser Ser Thr Ala Cys Leu 
            100                 105                 110         


Ser Phe Ser Leu Ser Ala Gly Lys Glu Ala Lys Lys Lys Ile Gly Lys 
        115                 120                 125             


Ser Arg Thr Thr Glu Asp Val Ser Met Pro Pro Leu His Arg Gly Val 
    130                 135                 140                 


Gly Thr Pro Ala Asn Ser Leu Glu Phe Ser Asp Pro Cys Pro Glu Ala 
145                 150                 155                 160 


Arg Glu Lys Leu Gln Glu Leu Cys Arg His Ile Glu Ala Glu Arg Ala 
                165                 170                 175     


Thr Trp Lys Gly Arg Asn Ile Ser Tyr Pro Met Ile Leu Arg Asn Tyr 
            180                 185                 190         


Lys Ala Lys Met Pro Ser His Leu Met Leu Ala Arg Lys Gly Asp Ser 
        195                 200                 205             


Gln Thr Pro Gly Leu His Tyr Pro Pro Thr Ala Gly Ala Gln Thr Leu 
    210                 215                 220                 


Ser Pro Thr Ser His Pro Ser Ser Ala Asn His His Phe Ser Gln His 
225                 230                 235                 240 


Cys Gln Glu Gly Lys Ala Pro Lys Lys Ala Phe Lys Phe His Tyr Thr 
                245                 250                 255     


Phe Tyr Asp Gly Ser Ser Phe Val Tyr Tyr Pro Ser Gly Asn Val Ala 
            260                 265                 270         


Val Cys Gln Ile Pro Thr Cys Cys Arg Gly Arg Thr Ile Thr Cys Leu 
        275                 280                 285             


Phe Asn Asp Ile Pro Gly Phe Ser Leu Leu Ala Leu Phe Asn Thr Glu 
    290                 295                 300                 


Gly Gln Gly Cys Val His Tyr Asn Leu Lys Thr Ser Cys Pro Tyr Val 
305                 310                 315                 320 


Leu Ile Leu Asp Glu Glu Gly Gly Thr Thr Asn Asp Gln Gln Gly Tyr 
                325                 330                 335     


Val Val His Lys Trp Ser Trp Thr Ser Arg Thr Glu Thr Leu Leu Ser 
            340                 345                 350         


Leu Glu Tyr Lys Val Asn Glu Glu Met Lys Leu Lys Val Leu Gly Gln 
        355                 360                 365             


Asp Ser Ile Thr Val Thr Phe Thr Ser Leu Asn Glu Thr Val Thr Leu 
    370                 375                 380                 


Thr Val Ser Ala Asn Asn Cys Pro His Gly Met Ala Tyr Asp Lys Arg 
385                 390                 395                 400 


Leu Asn Arg Arg Ile Ser Asn Met Asp Asp Lys Val Tyr Lys Met Ser 
                405                 410                 415     


Arg Ala Leu Ala Glu Ile Lys Lys Arg Phe Gln Lys Thr Val Thr Gln 
            420                 425                 430         


Phe Ile Asn Ser Ile Leu Leu Ala Ala Gly Leu Phe Thr Ile Glu Tyr 
        435                 440                 445             


Pro Thr Lys Lys Glu Glu Glu Glu Phe Val Arg Phe Lys Met Arg Ser 
    450                 455                 460                 


Arg Thr His Pro Glu Arg Leu Pro Lys Leu Ser Leu Tyr Ser Gly Glu 
465                 470                 475                 480 


Ser Leu Leu Arg Ser Gln Ser Gly His Leu Glu Ser Ser Ile Ala Glu 
                485                 490                 495     


Thr Leu Lys Asp Glu Pro Glu Ser Ala Pro Val Ser Pro Val Arg Lys 
            500                 505                 510         


Thr Thr Lys Ile His Thr Lys Ala Lys Val Thr Ser Arg Gly Lys Ala 
        515                 520                 525             


Arg Glu Gly Arg Ser Pro Thr Arg Trp Ala Ala Leu Pro Ser Asp Cys 
    530                 535                 540                 


Pro Leu Val Leu Arg Lys Leu Met Leu Lys Glu Asp Thr Arg Ala Gly 
545                 550                 555                 560 


Cys Lys Cys Leu Val Lys Ala Pro Leu Val Ser Asp Val Glu Leu Glu 
                565                 570                 575     


Arg Phe Leu Leu Ala Pro Arg Asp Pro Ser Gln Val Leu Val Phe Gly 
            580                 585                 590         


Ile Ile Ser Ser Gln Asn Tyr Thr Ser Thr Gly Gln Leu Gln Trp Leu 
        595                 600                 605             


Leu Asn Thr Leu Tyr Asn His Gln Gln Arg Gly Arg Gly Ser Pro Cys 
    610                 615                 620                 


Ile Gln Cys Arg Tyr Asp Ser Tyr Arg Leu Leu Gln Tyr Asp Leu Asp 
625                 630                 635                 640 


Ser Pro Leu Gln Glu Asp Pro Pro Leu Met Val Lys Lys Asn Ser Val 
                645                 650                 655     


Val Gln Gly Met Ile Leu Met Phe Ala Gly Gly Lys Leu Ile Phe Gly 
            660                 665                 670         


Gly Arg Val Leu Asn Gly Tyr Gly Leu Ser Lys Gln Asn Leu Leu Lys 
        675                 680                 685             


Gln Ile Phe Arg Ser Gln Gln Asp Tyr Lys Met Gly Tyr Phe Leu Pro 
    690                 695                 700                 


Asp Asp Tyr Lys Phe Ser Val Pro Asn Ser Val Leu Ser Leu Glu Asp 
705                 710                 715                 720 


Ser Glu Ser Val Lys Lys Ala Glu Ser Glu Asp Ile Gln Gly Ser Ser 
                725                 730                 735     


Ser Ser Leu Ala Leu Glu Asp Tyr Val Glu Lys Glu Leu Ser Leu Glu 
            740                 745                 750         


Ala Glu Lys Thr Arg Glu Pro Glu Val Glu Leu His Pro Leu Ser Arg 
        755                 760                 765             


Asp Ser Lys Ile Thr Ser Trp Lys Lys Gln Ala Ser Lys Lys 
    770                 775                 780         


<210>  1410
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf35__Homo_sapiens__NP_848029

<400>  1410

Met Lys Thr Met Ala Thr Arg Lys Arg Cys Lys Leu Ser Arg Thr Gly 
1               5                   10                  15      


Pro Glu Phe Glu Asn Val Ile Lys Arg Leu Leu Cys Ala Arg Thr Phe 
            20                  25                  30          


His Thr Arg Ile Gly Gly Asp Leu Thr His Gly Ile Ile Asn Arg Gly 
        35                  40                  45              


Arg Arg Ala Asn Ala Glu Gln Met Gly Leu Gln Gly Ser Ala Gln His 
    50                  55                  60                  


Phe Asn Ile Phe Pro Leu Asp Leu Trp Thr Gln Gly Lys Lys Thr Glu 
65                  70                  75                  80  


Val Gln Lys Arg Glu Gly Thr Asp Ser Ile Pro Ala Ala Gly Arg Ser 
                85                  90                  95      


Gly Thr Ala Asn Gln Pro Ser Ile Ala Pro His Arg Cys Leu Phe Ser 
            100                 105                 110         


Arg Gly Ile Thr Ala Leu Asp Gly Leu Lys Arg Gly Arg Gly Cys Asn 
        115                 120                 125             


Gly Ala Ala His Leu Val Arg Gly Asp Ala Trp Lys Thr Lys Leu Gly 
    130                 135                 140                 


Glu Pro Trp Val Ser Ile Ala Leu Ala Leu Ala Gly Pro Gly Ala Ile 
145                 150                 155                 160 


Leu Ile Leu Glu Leu Ser Trp Phe Leu Gly 
                165                 170 


<210>  1411
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf56__Homo_sapiens__NP_001007535

<400>  1411

Met Gly Thr Gly Ala Ser Glu Lys Gln Ala Glu Gln Lys Val Arg Arg 
1               5                   10                  15      


Ala Phe Glu Ala Ser Glu Glu Ala His Gly Thr Leu Ala Ala Ser Thr 
            20                  25                  30          


Pro Trp Val Ala Met Gly Ser Ala Tyr Gly Ser Cys Thr Cys Leu Gly 
        35                  40                  45              


Ala Gln Pro Val Thr Asp Leu Ala Leu Trp Pro Val Ile Tyr Ser Cys 
    50                  55                  60                  


Met Gly Phe Ser Pro Gln Ala Tyr Pro Ala Phe Trp Ala Tyr Pro Trp 
65                  70                  75                  80  


Val Leu Tyr Gly Gly Tyr Leu Trp Met Gly Tyr Pro Pro Pro Ala Ala 
                85                  90                  95      


Leu Val Pro Ser Val Trp Leu Tyr Trp Arg Gly Ala Ser Ser Phe Asp 
            100                 105                 110         


Pro Leu Ile Gly Ser Pro Tyr Leu Ala Ala Leu Ala Pro Asn Leu Phe 
        115                 120                 125             


Pro Phe Pro Met Lys Phe Pro Pro Thr Tyr Ser Leu Ala Ser Pro Thr 
    130                 135                 140                 


Leu Gly Gly Ala Thr Ser Ser His Cys Pro Gln Val Gly Cys Trp Thr 
145                 150                 155                 160 


Pro Ala Ser Ser Ala Pro Arg Ala Ala Val Glu Gly Pro Ser Arg Gly 
                165                 170                 175     


Ala Pro Tyr Leu Lys Thr Cys Lys Ala Pro Pro Ser Glu Trp Ala Ser 
            180                 185                 190         


Arg Phe Gly Ile Trp Ala Pro Leu Pro Cys Cys Ser Ser Glu Leu Arg 
        195                 200                 205             


Pro Leu Pro Pro Ser Pro Ile Glu Asp Ser Gln Leu Asp Pro Gly Cys 
    210                 215                 220                 


Ser Arg Ser Ser Ser Arg Ser Pro Cys Arg Ala Arg Arg Arg Leu Phe 
225                 230                 235                 240 


Glu Cys 
        


<210>  1412
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf58__Homo_sapiens__NP_001127942

<400>  1412

Met Lys Ser Glu Asn Gly Thr Val Val Gly Ser Phe Pro Ser Asp Glu 
1               5                   10                  15      


Gly Trp Pro Phe Ala Lys Tyr Leu Gly Ala Cys Gly Arg Met Val Ala 
            20                  25                  30          


Val Asn Tyr Val Gly Glu Glu Leu Trp Ser Tyr Phe Asn Ala Pro Trp 
        35                  40                  45              


Glu Lys Arg Val Asp Leu Ala Trp Gln Leu Met Glu Ile Ala Glu Gln 
    50                  55                  60                  


Leu Thr Asn Asn Asp Phe Glu Phe Ala Leu Tyr Leu Leu Asp Val Ser 
65                  70                  75                  80  


Phe Asp Asn Phe Ala Val Gly Pro Arg Asp Gly Lys Val Ile Ile Val 
                85                  90                  95      


Asp Ala Glu Asn Val Leu Val Ala Asp Lys Arg Leu Ile Arg Gln Asn 
            100                 105                 110         


Lys Pro Glu Asn Trp Asp Val Trp Tyr Glu Ser Lys Phe Asp Asp Cys 
        115                 120                 125             


Asp Lys Glu Ala Cys Leu Ser Phe Ser Lys Glu Ile Leu Cys Ala Arg 
    130                 135                 140                 


Ala Thr Val Asp His Asn Tyr Tyr Ala Val Cys Gln Asn Leu Leu Ser 
145                 150                 155                 160 


Arg His Ala Thr Trp Arg Gly Thr Ser Gly Gly Leu Leu His Asp Pro 
                165                 170                 175     


Pro Ser Glu Ile Ala Lys Asp Gly Arg Leu Glu Ala Leu Leu Asp Glu 
            180                 185                 190         


Cys Ala Asn Pro Lys Lys Arg Tyr Gly Arg Phe Gln Ala Ala Lys Glu 
        195                 200                 205             


Leu Arg Glu Tyr Leu Ala Gln Leu Ser Asn Asn Val Arg 
    210                 215                 220     


<210>  1413
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf67__Homo_sapiens__NP_940865

<400>  1413

Met Ile Lys Arg Lys Ile Trp Cys Asn Leu Cys Ile Asp Leu Val Ala 
1               5                   10                  15      


Phe Thr Ser Glu Ile Phe Lys Gly Ala Val Phe Gln Ser Leu Asp Gly 
            20                  25                  30          


Ile Val Val Ser Ala Asn Cys Lys Leu Arg Lys Ile Phe Thr Leu Lys 
        35                  40                  45              


Ser Lys Pro Gln Asp Thr Ala Asp Lys Asp Ala Val Tyr Gly Val Pro 
    50                  55                  60                  


Phe Ser Thr Asp Glu Pro Thr Asp Ile Ile Pro Arg Ser Cys Gln Leu 
65                  70                  75                  80  


Met Thr Asp Val Pro His Val Thr Gln Leu Leu Asn Met Thr Lys Leu 
                85                  90                  95      


Arg Gln Thr Glu Ile Lys Phe Gly Gly His Pro Leu Arg Ser Ala Glu 
            100                 105                 110         


Ser Asp Gln Phe Ile Asn Arg Gly Thr Ser Ile Thr Arg Asn Ser Lys 
        115                 120                 125             


Asn Gln Asp Val Cys His Ile Ala Phe Gly Ser Lys Val Leu Gly Pro 
    130                 135                 140                 


Pro Pro Leu Ser Gly Arg Arg Asn Asn Met Lys Ile Ser Ser Glu Thr 
145                 150                 155                 160 


Val Arg Ser Val Gly Ser Lys Asn Asn Arg Ser Cys Gln Pro Ser Thr 
                165                 170                 175     


Val Glu Lys Cys Val Asn Gly Thr Glu Met Ser Ala Leu Leu Ile Pro 
            180                 185                 190         


Glu Ser Glu Glu Gln Gly Asn Lys Glu Asn Ile His Gln Ile Lys Gln 
        195                 200                 205             


Thr Val Pro Ile His Ala Ala Asn Leu His Ile Met His Pro His Pro 
    210                 215                 220                 


Pro Gln Glu Pro Ser Ala Asp Lys Asn Asn Asn Arg Arg Arg Leu Arg 
225                 230                 235                 240 


Leu Lys Ser Thr Ser Arg Glu Arg Thr Glu Thr Pro Ser Gly Ser Ser 
                245                 250                 255     


Ser Gly Asn Asn Arg Ile Glu Asp Lys Ala Ser Thr Ile Leu Thr Thr 
            260                 265                 270         


Val Ser Gln Gln Gly Ala Glu Leu Leu Asn Ser Gly Thr Leu Gly Pro 
        275                 280                 285             


Gln Ser Pro Asp Gln Ser Asp Glu Trp Ile Phe Pro Glu Asn Ala Asp 
    290                 295                 300                 


His Ile Ser Tyr Leu Ala Ser Ser Arg Gln Ser Leu Leu Leu Gly Asp 
305                 310                 315                 320 


Asp Ser Cys Asn Pro Ser His Leu Trp Leu Glu Ala Ser Lys Glu Ser 
                325                 330                 335     


Glu His Asp Gln Gln Ala Glu Glu Ser Gln Ser Val Pro Lys Asp Ile 
            340                 345                 350         


Phe Thr Phe Ser Ser Arg Pro Arg Ser Ala Pro His Gly Lys Thr Gln 
        355                 360                 365             


Thr Met Ser Pro Glu Glu Leu Ser Phe Ile Leu Asp Leu Lys Glu Asp 
    370                 375                 380                 


Asn Ser Val Thr Ser Arg Asp Thr Gln Ser Glu Asp Asp Phe Tyr Gly 
385                 390                 395                 400 


Gly Asp Ser Ser Glu Glu Glu Tyr Asp Trp Arg Asn Tyr Gln Pro Ser 
                405                 410                 415     


Gln Met Ser Glu Ser Glu Leu Gln Met Leu Ala Ser Leu Arg Trp Gln 
            420                 425                 430         


Gln Asn Glu Glu Leu Glu Asp Ala Gly Thr Ser His Gly Leu Ser Ala 
        435                 440                 445             


Ser Gln Val Asp Asn Cys Asn Val Ser Ile Ser Thr Ser Ser Asp Asp 
    450                 455                 460                 


Thr Thr Thr Trp Asn Ser Cys Leu Pro Pro Pro Val Asn Gln Gly Arg 
465                 470                 475                 480 


His Tyr Gln Lys Glu Met Asn Pro Pro Ser Pro Ser Asn Pro Arg Asp 
                485                 490                 495     


Trp Leu Asn Met Leu Ser Pro Pro Ile Val Pro Pro Ser Gln Gln Pro 
            500                 505                 510         


Ala Glu Gln Arg Pro Asp Ser Cys Glu Ser Leu Ser Val Gln Gly Glu 
        515                 520                 525             


Glu Asp Leu Ser Val Glu Glu Asp Glu Glu Val Leu Thr Leu Leu Tyr 
    530                 535                 540                 


Asp Pro Cys Leu Asn Cys Tyr Phe Asp Pro Gln Thr Gly Lys Tyr Tyr 
545                 550                 555                 560 


Glu Leu Val 
            


<210>  1414
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3orf79__Homo_sapiens__NP_001094807

<400>  1414

Met His Val Cys Asp Leu Gln Lys Leu Val Arg Ile Gln Leu Ala Phe 
1               5                   10                  15      


Thr Thr Phe Pro Trp Met Phe Ser Cys His Leu Leu Pro Thr Pro Glu 
            20                  25                  30          


Leu Ser Ser Lys Arg Asn Gln Cys Leu Leu Tyr Lys Thr Ser Gly Cys 
        35                  40                  45              


Leu Thr Gln Met Pro Ile Leu Tyr Gly His Pro Ala Thr Leu Leu Lys 
    50                  55                  60                  


Asp Tyr Ile Leu Gln Ala Ile Leu Gln Pro Gly Lys Lys Ile Gln Gly 
65                  70                  75                  80  


Gly Thr Glu Ile Gln Arg Gly Ser Phe Ala Asn Gln Tyr Gln Thr Asp 
                85                  90                  95      


Ala Ser His Leu 
            100 


<210>  1415
<211>  1698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4A__Homo_sapiens__NP_001239133

<400>  1415

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Asp Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Pro  Cys Pro Val Leu Asp  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Asn Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Val Asp Leu Leu  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ser Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Leu 
    1445                 1450                 1455             


Thr Ser  Leu Ser Asp Arg Tyr  Val Ser His Phe Glu  Thr Glu Gly 
    1460                 1465                 1470             


Pro His  Val Leu Leu Tyr Phe  Asp Ser Val Pro Thr  Ser Arg Glu 
    1475                 1480                 1485             


Cys Val  Gly Phe Glu Ala Val  Gln Glu Val Pro Val  Gly Leu Val 
    1490                 1495                 1500             


Gln Pro  Ala Ser Ala Thr Leu  Tyr Asp Tyr Tyr Asn  Pro Glu Arg 
    1505                 1510                 1515             


Arg Cys  Ser Val Phe Tyr Gly  Ala Pro Ser Lys Ser  Arg Leu Leu 
    1520                 1525                 1530             


Ala Thr  Leu Cys Ser Ala Glu  Val Cys Gln Cys Ala  Glu Gly Lys 
    1535                 1540                 1545             


Cys Pro  Arg Gln Arg Arg Ala  Leu Glu Arg Gly Leu  Gln Asp Glu 
    1550                 1555                 1560             


Asp Gly  Tyr Arg Met Lys Phe  Ala Cys Tyr Tyr Pro  Arg Val Glu 
    1565                 1570                 1575             


Tyr Gly  Phe Gln Val Lys Val  Leu Arg Glu Asp Ser  Arg Ala Ala 
    1580                 1585                 1590             


Phe Arg  Leu Phe Glu Thr Lys  Ile Thr Gln Val Leu  His Phe Thr 
    1595                 1600                 1605             


Lys Asp  Val Lys Ala Ala Ala  Asn Gln Met Arg Asn  Phe Leu Val 
    1610                 1615                 1620             


Arg Ala  Ser Cys Arg Leu Arg  Leu Glu Pro Gly Lys  Glu Tyr Leu 
    1625                 1630                 1635             


Ile Met  Gly Leu Asp Gly Ala  Thr Tyr Asp Leu Glu  Gly His Pro 
    1640                 1645                 1650             


Gln Tyr  Leu Leu Asp Ser Asn  Ser Trp Ile Glu Glu  Met Pro Ser 
    1655                 1660                 1665             


Glu Arg  Leu Cys Arg Ser Thr  Arg Gln Arg Ala Ala  Cys Ala Gln 
    1670                 1675                 1680             


Leu Asn  Asp Phe Leu Gln Glu  Tyr Gly Thr Gln Gly  Cys Gln Val 
    1685                 1690                 1695             


<210>  1416
<211>  1744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4B_2__Homo_sapiens__NP_001229752

<400>  1416

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Tyr Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  1417
<211>  1744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4B__Homo_sapiens__NP_001002029

<400>  1417

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  1418
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4BPA__Homo_sapiens__XP_005273308

<400>  1418

Met His Pro Pro Lys Thr Pro Ser Gly Ala Leu His Arg Lys Arg Lys 
1               5                   10                  15      


Met Ala Ala Trp Pro Phe Ser Arg Leu Trp Lys Val Ser Asp Pro Ile 
            20                  25                  30          


Leu Phe Gln Met Thr Leu Ile Ala Ala Leu Leu Pro Ala Val Leu Gly 
        35                  40                  45              


Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp Ile 
    50                  55                  60                  


Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr Thr 
65                  70                  75                  80  


Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr Cys 
                85                  90                  95      


Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys Arg 
            100                 105                 110         


Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys Thr 
        115                 120                 125             


Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly Phe 
    130                 135                 140                 


Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp Arg Gly 
145                 150                 155                 160 


Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys Lys 
                165                 170                 175     


Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn Phe 
            180                 185                 190         


Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe Ser 
        195                 200                 205             


Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu Thr Ile 
    210                 215                 220                 


Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu Lys Ile Thr Cys Arg 
225                 230                 235                 240 


Lys Pro Asp Val Ser His Gly Glu Met Val Ser Gly Phe Gly Pro Ile 
                245                 250                 255     


Tyr Asn Tyr Lys Asp Thr Ile Val Phe Lys Cys Gln Lys Gly Phe Val 
            260                 265                 270         


Leu Arg Gly Ser Ser Val Ile His Cys Asp Ala Asp Ser Lys Trp Asn 
        275                 280                 285             


Pro Ser Pro Pro Ala Cys Glu Pro Asn Ser Cys Ile Asn Leu Pro Asp 
    290                 295                 300                 


Ile Pro His Ala Ser Trp Glu Thr Tyr Pro Arg Pro Thr Lys Glu Asp 
305                 310                 315                 320 


Val Tyr Val Val Gly Thr Val Leu Arg Tyr Arg Cys His Pro Gly Tyr 
                325                 330                 335     


Lys Pro Thr Thr Asp Glu Pro Thr Thr Val Ile Cys Gln Lys Asn Leu 
            340                 345                 350         


Arg Trp Thr Pro Tyr Gln Gly Cys Glu Ala Leu Cys Cys Pro Glu Pro 
        355                 360                 365             


Lys Leu Asn Asn Gly Glu Ile Thr Gln His Arg Lys Ser Arg Pro Ala 
    370                 375                 380                 


Asn His Cys Val Tyr Phe Tyr Gly Asp Glu Ile Ser Phe Ser Cys His 
385                 390                 395                 400 


Glu Thr Ser Arg Phe Ser Ala Ile Cys Gln Gly Asp Gly Thr Trp Ser 
                405                 410                 415     


Pro Arg Thr Pro Ser Cys Gly Asp Ile Cys Asn Phe Pro Pro Lys Ile 
            420                 425                 430         


Ala His Gly His Tyr Lys Gln Ser Ser Ser Tyr Ser Phe Phe Lys Glu 
        435                 440                 445             


Glu Ile Ile Tyr Glu Cys Asp Lys Gly Tyr Ile Leu Val Gly Gln Ala 
    450                 455                 460                 


Lys Leu Ser Cys Ser Tyr Ser His Trp Ser Ala Pro Ala Pro Gln Cys 
465                 470                 475                 480 


Lys Ala Leu Cys Arg Lys Pro Glu Leu Val Asn Gly Arg Leu Ser Val 
                485                 490                 495     


Asp Lys Asp Gln Tyr Val Glu Pro Glu Asn Val Thr Ile Gln Cys Asp 
            500                 505                 510         


Ser Gly Tyr Gly Val Val Gly Pro Gln Ser Ile Thr Cys Ser Gly Asn 
        515                 520                 525             


Arg Thr Trp Tyr Pro Glu Val Pro Lys Cys Glu Trp Glu Thr Pro Glu 
    530                 535                 540                 


Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
545                 550                 555                 560 


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
                565                 570                 575     


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
            580                 585                 590         


Leu Asp Lys Glu Leu 
        595         


<210>  1419
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4BPB__Homo_sapiens__NP_001017365

<400>  1419

Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser 
1               5                   10                  15      


Ala Ser Asp Ala Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser 
            20                  25                  30          


Ile Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val 
        35                  40                  45              


Cys Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn 
    50                  55                  60                  


Ala Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His 
65                  70                  75                  80  


Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro 
                85                  90                  95      


Val Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile 
            100                 105                 110         


Leu Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala 
        115                 120                 125             


Pro Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn 
    130                 135                 140                 


Pro Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr 
145                 150                 155                 160 


Ile Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu 
                165                 170                 175     


Gln Gln Cys Val Asp Gly Glu Trp Ser Ser Ala Leu Pro Val Cys Lys 
            180                 185                 190         


Leu Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala 
        195                 200                 205             


Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln 
    210                 215                 220                 


Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu 
225                 230                 235                 240 


Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
                245                 250         


<210>  1420
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf22__Homo_sapiens__NP_001193926

<400>  1420

Met Asp Gln Glu Glu Gly Leu Lys Ala Leu Asp Asn Ile Val Thr Gln 
1               5                   10                  15      


Phe Asn Ala Tyr Glu Asp Phe Leu Asp Ser Gln Ile Thr Thr Val Asp 
            20                  25                  30          


Leu Tyr Tyr Leu Glu Asp Glu Thr Leu Ala Arg Gln Leu Val Glu Leu 
        35                  40                  45              


Gly Tyr Arg Gly Thr Gly Glu Arg Val Lys Arg Glu Asp Phe Glu Ala 
    50                  55                  60                  


Arg Lys Ala Ala Ile Glu Ile Ala Arg Leu Ala Glu Arg Ala Gln Gln 
65                  70                  75                  80  


Lys Thr Leu Thr Ser Ala Gly Lys Asp Leu Gln Asp Asn Phe Leu Thr 
                85                  90                  95      


Ala Leu Ala Met Arg Glu Glu Asp Asn Arg Ser Gly Lys Leu Ser Leu 
            100                 105                 110         


Asn Gln Gln Glu Thr Asp Ala Ala His Ile Leu Lys Lys Gln Leu Ala 
        115                 120                 125             


Ser Val Ile Phe Ile Arg Asp Arg Asn Ser His Gly Gln Glu Ile Ser 
    130                 135                 140                 


Gly Tyr Ile Asp Tyr Ala His Arg Leu Lys Thr Glu Asp Phe Glu Val 
145                 150                 155                 160 


Tyr Phe Thr Gly Lys Lys Arg Leu Leu Pro Arg Pro Thr Asp Ile Ser 
                165                 170                 175     


Phe Tyr Asn Trp Asp Ala Asp Ile Ala Val Ser Asn Ser Ser Pro Asn 
            180                 185                 190         


Tyr Gln Val Ile Ala Asp Asn Pro Glu Gly Leu Leu Phe Arg Tyr Lys 
        195                 200                 205             


Arg Asp Arg Lys Ile Leu Asn Val Asp Pro Lys Ala Gln Pro Gly Asp 
    210                 215                 220                 


Asn Ser Thr Arg Ile Thr Ile Leu Thr Glu Leu Tyr Val Gln Ala Val 
225                 230                 235                 240 


Ile Phe Asp His Ile Ser Arg Arg Lys Thr 
                245                 250 


<210>  1421
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf26__Homo_sapiens__NP_001193910

<400>  1421

Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Ala Leu Ser Thr Phe Tyr Leu Gln Gln His 
            20                  25                  30          


Ile Asn Leu His Met Asp Lys Lys Arg Tyr Leu Arg Leu Leu Glu Ile 
        35                  40                  45              


His Lys Ile Met Arg Thr Leu Pro Thr Ala Arg Ser Leu His Ser Pro 
    50                  55                  60                  


Leu His Leu Pro Arg Gly Val Arg Ser Gln Gly Pro Ser Pro Ser Gln 
65                  70                  75                  80  


Arg His Pro Gly Val Pro Ser Ile Phe Phe His Glu Gly Pro Glu Ser 
                85                  90                  95      


Ile Leu Gly Phe Gln Thr Asp Leu Ser Ser Leu Gln Gly Val Thr Thr 
            100                 105                 110         


Val Phe His Ser Ser His Phe Ile Gly His Thr Val Thr Leu Leu Ile 
        115                 120                 125             


Gly Ile Ser Pro Glu Glu Asp Ser Arg Glu Glu Ala His Leu Arg Lys 
    130                 135                 140                 


Ala Glu Arg Glu Glu Lys Pro Lys His Thr Glu Ala Lys Lys Ser Leu 
145                 150                 155                 160 


Ser Phe Arg Lys Lys Gln Gln Lys Asp Phe Cys Phe Ile Phe Arg Asn 
                165                 170                 175     


<210>  1422
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf27__Homo_sapiens__NP_060337

<400>  1422

Met Val Gly Gly Gly Gly Lys Arg Arg Pro Gly Gly Glu Gly Pro Gln 
1               5                   10                  15      


Cys Glu Lys Thr Thr Asp Val Lys Lys Ser Lys Phe Cys Glu Ala Asp 
            20                  25                  30          


Val Ser Ser Asp Leu Arg Lys Glu Val Glu Asn His Tyr Lys Leu Ser 
        35                  40                  45              


Leu Pro Glu Asp Phe Tyr His Phe Trp Lys Phe Cys Glu Glu Leu Asp 
    50                  55                  60                  


Pro Glu Lys Pro Ser Asp Ser Leu Ser Ala Ser Leu Gly Leu Gln Leu 
65                  70                  75                  80  


Val Gly Pro Tyr Asp Ile Leu Ala Gly Lys His Lys Thr Lys Lys Lys 
                85                  90                  95      


Ser Thr Gly Leu Asn Phe Asn Leu His Trp Arg Phe Tyr Tyr Asp Pro 
            100                 105                 110         


Pro Glu Phe Gln Thr Ile Ile Ile Gly Asp Asn Lys Thr Gln Tyr His 
        115                 120                 125             


Met Gly Tyr Phe Arg Asp Ser Pro Asp Glu Phe Pro Val Tyr Val Gly 
    130                 135                 140                 


Ile Asn Glu Ala Lys Lys Asn Cys Ile Ile Val Pro Asn Gly Asp Asn 
145                 150                 155                 160 


Val Phe Ala Ala Val Lys Leu Phe Leu Thr Lys Lys Leu Arg Glu Ile 
                165                 170                 175     


Thr Asp Lys Lys Lys Ile Asn Leu Leu Lys Asn Ile Asp Glu Lys Leu 
            180                 185                 190         


Thr Glu Ala Ala Arg Glu Leu Gly Tyr Ser Leu Glu Gln Arg Thr Val 
        195                 200                 205             


Lys Met Lys Gln Arg Asp Lys Lys Val Val Thr Lys Thr Phe His Gly 
    210                 215                 220                 


Ala Gly Leu Val Val Pro Val Asp Lys Asn Asp Val Gly Tyr Arg Glu 
225                 230                 235                 240 


Leu Pro Glu Thr Asp Ala Asp Leu Lys Arg Ile Cys Lys Thr Ile Val 
                245                 250                 255     


Glu Ala Ala Ser Asp Glu Glu Arg Leu Lys Ala Phe Ala Pro Ile Gln 
            260                 265                 270         


Glu Met Met Thr Phe Val Gln Phe Ala Asn Asp Glu Cys Asp Tyr Gly 
        275                 280                 285             


Met Gly Leu Glu Leu Gly Met Asp Leu Phe Cys Tyr Gly Ser His Tyr 
    290                 295                 300                 


Phe His Lys Val Ala Gly Gln Leu Leu Pro Leu Ala Tyr Asn Leu Leu 
305                 310                 315                 320 


Lys Arg Asn Leu Phe Ala Glu Ile Ile Glu Glu His Leu Ala Asn Arg 
                325                 330                 335     


Ser Gln Glu Asn Ile Asp Gln Leu Ala Ala 
            340                 345     


<210>  1423
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf32__Homo_sapiens__NP_689613

<400>  1423

Met Cys Ser Ala Gly Glu Leu Leu Arg Gly Gly Asp Gly Gly Glu Arg 
1               5                   10                  15      


Asp Glu Asp Gly Asp Ala Leu Ala Glu Arg Glu Ala Ala Gly Thr Glu 
            20                  25                  30          


Trp Asp Pro Gly Ala Ser Pro Arg Arg Arg Gly Gln Arg Pro Lys Glu 
        35                  40                  45              


Ser Glu Gln Asp Val Glu Asp Ser Gln Asn His Thr Gly Glu Pro Val 
    50                  55                  60                  


Gly Asp Asp Tyr Lys Lys Met Gly Thr Leu Phe Gly Glu Leu Asn Lys 
65                  70                  75                  80  


Asn Leu Ile Asn Met Gly Phe Thr Arg Met Tyr Phe Gly Glu Arg Ile 
                85                  90                  95      


Val Glu Pro Val Ile Val Ile Phe Phe Trp Val Met Leu Trp Phe Leu 
            100                 105                 110         


Gly Leu Gln Ala Leu Gly Leu Val Ala Val Leu Cys Leu Val Ile Ile 
        115                 120                 125             


Tyr Val Gln Gln 
    130         


<210>  1424
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf33__Homo_sapiens__NP_001093253

<400>  1424

Met Asp Phe Lys Ile Glu His Thr Trp Asp Gly Phe Pro Val Lys His 
1               5                   10                  15      


Glu Pro Val Phe Ile Arg Leu Asn Pro Gly Asp Arg Gly Val Met Met 
            20                  25                  30          


Asp Ile Ser Ala Pro Phe Phe Arg Asp Pro Pro Ala Pro Leu Gly Glu 
        35                  40                  45              


Pro Gly Lys Pro Phe Asn Glu Leu Trp Asp Tyr Glu Val Val Glu Ala 
    50                  55                  60                  


Phe Phe Leu Asn Asp Ile Thr Glu Gln Tyr Leu Glu Val Glu Leu Cys 
65                  70                  75                  80  


Pro His Gly Gln His Leu Val Leu Leu Leu Ser Gly Arg Arg Asn Val 
                85                  90                  95      


Trp Lys Gln Glu Leu Pro Leu Ser Phe Arg Met Ser Arg Gly Glu Thr 
            100                 105                 110         


Lys Trp Glu Gly Lys Ala Tyr Leu Pro Trp Ser Tyr Phe Pro Pro Asn 
        115                 120                 125             


Val Thr Lys Phe Asn Ser Phe Ala Ile His Gly Ser Lys Asp Lys Arg 
    130                 135                 140                 


Ser Tyr Glu Ala Leu Tyr Pro Val Pro Gln His Glu Leu Gln Gln Gly 
145                 150                 155                 160 


Gln Lys Pro Asp Phe His Cys Leu Glu Tyr Phe Lys Ser Phe Asn Phe 
                165                 170                 175     


Asn Thr Leu Leu Gly Glu Glu Trp Lys Gln Pro Glu Ser Asp Leu Trp 
            180                 185                 190         


Leu Ile Glu Lys Cys Asp Ile 
        195                 


<210>  1425
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf36__Homo_sapiens__XP_011529917

<400>  1425

Met Ala Tyr Gly Val Pro Arg Lys Asn Thr Val Lys Thr Ile Leu Arg 
1               5                   10                  15      


Gly Ser Cys Tyr Asn Val Gln Glu Pro Trp Asp Ile Ala Leu Leu Ala 
            20                  25                  30          


Lys Thr Trp Ser Thr Asn Leu Ala Asn Ile Lys Leu Pro Phe Leu Glu 
        35                  40                  45              


Glu Ile Ser Phe Gly Gly Ser Val Gln Leu Thr Lys Cys Thr Thr Ile 
    50                  55                  60                  


Lys Asp Gly Leu Leu Pro Ser Ala Glu Ser Ile Lys Leu Glu Arg Glu 
65                  70                  75                  80  


Tyr Glu Val Lys Arg Leu Cys Lys Leu Lys Cys Gln Glu Asn Thr Ser 
                85                  90                  95      


Lys Glu Ile Gln Leu Leu Leu Arg Glu Arg Pro Ala Gly Leu Arg Arg 
            100                 105                 110         


Pro Leu Pro Ser Lys 
        115         


<210>  1426
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf48__Homo_sapiens__NP_001135408

<400>  1426

Met Ala Pro Pro Pro Ala Cys Arg Ser Pro Met Ser Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Ser Leu Ala Leu Leu Gly Ala Arg Ala 
            20                  25                  30          


Arg Ala Glu Pro Ala Gly Ser Ala Val Pro Ala Gln Ser Arg Pro Cys 
        35                  40                  45              


Val Asp Cys His Ala Phe Glu Phe Met Gln Arg Ala Leu Gln Asp Leu 
    50                  55                  60                  


Arg Lys Thr Ala Cys Ser Leu Asp Ala Arg Thr Glu Thr Leu Leu Leu 
65                  70                  75                  80  


Gln Ala Glu Arg Arg Ala Leu Cys Ala Cys Trp Pro Ala Gly His 
                85                  90                  95  


<210>  1427
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4orf51__Homo_sapiens__XP_011530499

<400>  1427

Met Ser His Tyr Phe Tyr Leu Thr Pro Gln Ile Leu Leu Pro Phe Ser 
1               5                   10                  15      


Pro Leu Thr Ser Gln Glu Phe Asp Leu Ile Arg Arg Lys Ala Gly Ala 
            20                  25                  30          


Ser Trp Gln Asp Glu Thr Arg Trp Ser Asp Ser Ser Val Thr Thr Tyr 
        35                  40                  45              


Thr Gly Ser Tyr Arg Lys Lys Gln Leu Asp Lys Ser Met Cys Ser Gln 
    50                  55                  60                  


Phe Ser Phe Arg Ala Gly Gln His Glu Pro Glu Cys Lys Gln Met Ser 
65                  70                  75                  80  


Leu Thr Asn Ser Ser Ala Cys His Leu Leu Cys Trp Ala Gly Thr Gln 
                85                  90                  95      


Glu Thr Thr Asp Ile Lys Gly Leu Phe Pro Asp Ile Thr Arg Pro Phe 
            100                 105                 110         


Lys Lys Ser Phe Asp Val Lys His Gly Val Ala His Gln Ile Trp Asp 
        115                 120                 125             


Phe Gly Asp Cys Phe Pro Thr Pro Pro Asn Tyr Gly Lys Tyr Cys Val 
    130                 135                 140                 


Arg Pro Lys Lys Pro Ala Gln Glu Ala Leu Ile Asn Tyr Ser Arg Arg 
145                 150                 155                 160 


Gly Lys Gly Val Leu Lys His Leu His Gly Arg Cys Asp Ser Glu Ser 
                165                 170                 175     


Lys Val Cys Ser Ser Glu Asp Ser Glu Ala Asp Arg Tyr Ser Asp Tyr 
            180                 185                 190         


Gly Trp Gly Gly Pro Ser Ser Pro Phe Asn 
        195                 200         


<210>  1428
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5AR1__Homo_sapiens__NP_001727

<400>  1428

Met Asn Ser Phe Asn Tyr Thr Thr Pro Asp Tyr Gly His Tyr Asp Asp 
1               5                   10                  15      


Lys Asp Thr Leu Asp Leu Asn Thr Pro Val Asp Lys Thr Ser Asn Thr 
            20                  25                  30          


Leu Arg Val Pro Asp Ile Leu Ala Leu Val Ile Phe Ala Val Val Phe 
        35                  40                  45              


Leu Val Gly Val Leu Gly Asn Ala Leu Val Val Trp Val Thr Ala Phe 
    50                  55                  60                  


Glu Ala Lys Arg Thr Ile Asn Ala Ile Trp Phe Leu Asn Leu Ala Val 
65                  70                  75                  80  


Ala Asp Phe Leu Ser Cys Leu Ala Leu Pro Ile Leu Phe Thr Ser Ile 
                85                  90                  95      


Val Gln His His His Trp Pro Phe Gly Gly Ala Ala Cys Ser Ile Leu 
            100                 105                 110         


Pro Ser Leu Ile Leu Leu Asn Met Tyr Ala Ser Ile Leu Leu Leu Ala 
        115                 120                 125             


Thr Ile Ser Ala Asp Arg Phe Leu Leu Val Phe Lys Pro Ile Trp Cys 
    130                 135                 140                 


Gln Asn Phe Arg Gly Ala Gly Leu Ala Trp Ile Ala Cys Ala Val Ala 
145                 150                 155                 160 


Trp Gly Leu Ala Leu Leu Leu Thr Ile Pro Ser Phe Leu Tyr Arg Val 
                165                 170                 175     


Val Arg Glu Glu Tyr Phe Pro Pro Lys Val Leu Cys Gly Val Asp Tyr 
            180                 185                 190         


Ser His Asp Lys Arg Arg Glu Arg Ala Val Ala Ile Val Arg Leu Val 
        195                 200                 205             


Leu Gly Phe Leu Trp Pro Leu Leu Thr Leu Thr Ile Cys Tyr Thr Phe 
    210                 215                 220                 


Ile Leu Leu Arg Thr Trp Ser Arg Arg Ala Thr Arg Ser Thr Lys Thr 
225                 230                 235                 240 


Leu Lys Val Val Val Ala Val Val Ala Ser Phe Phe Ile Phe Trp Leu 
                245                 250                 255     


Pro Tyr Gln Val Thr Gly Ile Met Met Ser Phe Leu Glu Pro Ser Ser 
            260                 265                 270         


Pro Thr Phe Leu Leu Leu Asn Lys Leu Asp Ser Leu Cys Val Ser Phe 
        275                 280                 285             


Ala Tyr Ile Asn Cys Cys Ile Asn Pro Ile Ile Tyr Val Val Ala Gly 
    290                 295                 300                 


Gln Gly Phe Gln Gly Arg Leu Arg Lys Ser Leu Pro Ser Leu Leu Arg 
305                 310                 315                 320 


Asn Val Leu Thr Glu Glu Ser Val Val Arg Glu Ser Lys Ser Phe Thr 
                325                 330                 335     


Arg Ser Thr Val Asp Thr Met Ala Gln Lys Thr Gln Ala Val 
            340                 345                 350 


<210>  1429
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5AR2__Homo_sapiens__NP_001258679

<400>  1429

Met Gly Asn Asp Ser Val Ser Tyr Glu Tyr Gly Asp Tyr Ser Asp Leu 
1               5                   10                  15      


Ser Asp Arg Pro Val Asp Cys Leu Asp Gly Ala Cys Leu Ala Ile Asp 
            20                  25                  30          


Pro Leu Arg Val Ala Pro Leu Pro Leu Tyr Ala Ala Ile Phe Leu Val 
        35                  40                  45              


Gly Val Pro Gly Asn Ala Met Val Ala Trp Val Ala Gly Lys Val Ala 
    50                  55                  60                  


Arg Arg Arg Val Gly Ala Thr Trp Leu Leu His Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Cys Cys Leu Ser Leu Pro Ile Leu Ala Val Pro Ile Ala Arg 
                85                  90                  95      


Gly Gly His Trp Pro Tyr Gly Ala Val Gly Cys Arg Ala Leu Pro Ser 
            100                 105                 110         


Ile Ile Leu Leu Thr Met Tyr Ala Ser Val Leu Leu Leu Ala Ala Leu 
        115                 120                 125             


Ser Ala Asp Leu Cys Phe Leu Ala Leu Gly Pro Ala Trp Trp Ser Thr 
    130                 135                 140                 


Val Gln Arg Ala Cys Gly Val Gln Val Ala Cys Gly Ala Ala Trp Thr 
145                 150                 155                 160 


Leu Ala Leu Leu Leu Thr Val Pro Ser Ala Ile Tyr Arg Arg Leu His 
                165                 170                 175     


Gln Glu His Phe Pro Ala Arg Leu Gln Cys Val Val Asp Tyr Gly Gly 
            180                 185                 190         


Ser Ser Ser Thr Glu Asn Ala Val Thr Ala Ile Arg Phe Leu Phe Gly 
        195                 200                 205             


Phe Leu Gly Pro Leu Val Ala Val Ala Ser Cys His Ser Ala Leu Leu 
    210                 215                 220                 


Cys Trp Ala Ala Arg Arg Cys Arg Pro Leu Gly Thr Ala Ile Val Val 
225                 230                 235                 240 


Gly Phe Phe Val Cys Trp Ala Pro Tyr His Leu Leu Gly Leu Val Leu 
                245                 250                 255     


Thr Val Ala Ala Pro Asn Ser Ala Leu Leu Ala Arg Ala Leu Arg Ala 
            260                 265                 270         


Glu Pro Leu Ile Val Gly Leu Ala Leu Ala His Ser Cys Leu Asn Pro 
        275                 280                 285             


Met Leu Phe Leu Tyr Phe Gly Arg Ala Gln Leu Arg Arg Ser Leu Pro 
    290                 295                 300                 


Ala Ala Cys His Trp Ala Leu Arg Glu Ser Gln Gly Gln Asp Glu Ser 
305                 310                 315                 320 


Val Asp Ser Lys Lys Ser Thr Ser His Asp Leu Val Ser Glu Met Glu 
                325                 330                 335     


Val 
    


<210>  1430
<211>  1676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5__Homo_sapiens__NP_001726

<400>  1430

Met Gly Leu Leu Gly Ile Leu Cys Phe Leu Ile Phe Leu Gly Lys Thr 
1               5                   10                  15      


Trp Gly Gln Glu Gln Thr Tyr Val Ile Ser Ala Pro Lys Ile Phe Arg 
            20                  25                  30          


Val Gly Ala Ser Glu Asn Ile Val Ile Gln Val Tyr Gly Tyr Thr Glu 
        35                  40                  45              


Ala Phe Asp Ala Thr Ile Ser Ile Lys Ser Tyr Pro Asp Lys Lys Phe 
    50                  55                  60                  


Ser Tyr Ser Ser Gly His Val His Leu Ser Ser Glu Asn Lys Phe Gln 
65                  70                  75                  80  


Asn Ser Ala Ile Leu Thr Ile Gln Pro Lys Gln Leu Pro Gly Gly Gln 
                85                  90                  95      


Asn Pro Val Ser Tyr Val Tyr Leu Glu Val Val Ser Lys His Phe Ser 
            100                 105                 110         


Lys Ser Lys Arg Met Pro Ile Thr Tyr Asp Asn Gly Phe Leu Phe Ile 
        115                 120                 125             


His Thr Asp Lys Pro Val Tyr Thr Pro Asp Gln Ser Val Lys Val Arg 
    130                 135                 140                 


Val Tyr Ser Leu Asn Asp Asp Leu Lys Pro Ala Lys Arg Glu Thr Val 
145                 150                 155                 160 


Leu Thr Phe Ile Asp Pro Glu Gly Ser Glu Val Asp Met Val Glu Glu 
                165                 170                 175     


Ile Asp His Ile Gly Ile Ile Ser Phe Pro Asp Phe Lys Ile Pro Ser 
            180                 185                 190         


Asn Pro Arg Tyr Gly Met Trp Thr Ile Lys Ala Lys Tyr Lys Glu Asp 
        195                 200                 205             


Phe Ser Thr Thr Gly Thr Ala Tyr Phe Glu Val Lys Glu Tyr Val Leu 
    210                 215                 220                 


Pro His Phe Ser Val Ser Ile Glu Pro Glu Tyr Asn Phe Ile Gly Tyr 
225                 230                 235                 240 


Lys Asn Phe Lys Asn Phe Glu Ile Thr Ile Lys Ala Arg Tyr Phe Tyr 
                245                 250                 255     


Asn Lys Val Val Thr Glu Ala Asp Val Tyr Ile Thr Phe Gly Ile Arg 
            260                 265                 270         


Glu Asp Leu Lys Asp Asp Gln Lys Glu Met Met Gln Thr Ala Met Gln 
        275                 280                 285             


Asn Thr Met Leu Ile Asn Gly Ile Ala Gln Val Thr Phe Asp Ser Glu 
    290                 295                 300                 


Thr Ala Val Lys Glu Leu Ser Tyr Tyr Ser Leu Glu Asp Leu Asn Asn 
305                 310                 315                 320 


Lys Tyr Leu Tyr Ile Ala Val Thr Val Ile Glu Ser Thr Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Ala Glu Ile Pro Gly Ile Lys Tyr Val Leu Ser Pro Tyr 
            340                 345                 350         


Lys Leu Asn Leu Val Ala Thr Pro Leu Phe Leu Lys Pro Gly Ile Pro 
        355                 360                 365             


Tyr Pro Ile Lys Val Gln Val Lys Asp Ser Leu Asp Gln Leu Val Gly 
    370                 375                 380                 


Gly Val Pro Val Thr Leu Asn Ala Gln Thr Ile Asp Val Asn Gln Glu 
385                 390                 395                 400 


Thr Ser Asp Leu Asp Pro Ser Lys Ser Val Thr Arg Val Asp Asp Gly 
                405                 410                 415     


Val Ala Ser Phe Val Leu Asn Leu Pro Ser Gly Val Thr Val Leu Glu 
            420                 425                 430         


Phe Asn Val Lys Thr Asp Ala Pro Asp Leu Pro Glu Glu Asn Gln Ala 
        435                 440                 445             


Arg Glu Gly Tyr Arg Ala Ile Ala Tyr Ser Ser Leu Ser Gln Ser Tyr 
    450                 455                 460                 


Leu Tyr Ile Asp Trp Thr Asp Asn His Lys Ala Leu Leu Val Gly Glu 
465                 470                 475                 480 


His Leu Asn Ile Ile Val Thr Pro Lys Ser Pro Tyr Ile Asp Lys Ile 
                485                 490                 495     


Thr His Tyr Asn Tyr Leu Ile Leu Ser Lys Gly Lys Ile Ile His Phe 
            500                 505                 510         


Gly Thr Arg Glu Lys Phe Ser Asp Ala Ser Tyr Gln Ser Ile Asn Ile 
        515                 520                 525             


Pro Val Thr Gln Asn Met Val Pro Ser Ser Arg Leu Leu Val Tyr Tyr 
    530                 535                 540                 


Ile Val Thr Gly Glu Gln Thr Ala Glu Leu Val Ser Asp Ser Val Trp 
545                 550                 555                 560 


Leu Asn Ile Glu Glu Lys Cys Gly Asn Gln Leu Gln Val His Leu Ser 
                565                 570                 575     


Pro Asp Ala Asp Ala Tyr Ser Pro Gly Gln Thr Val Ser Leu Asn Met 
            580                 585                 590         


Ala Thr Gly Met Asp Ser Trp Val Ala Leu Ala Ala Val Asp Ser Ala 
        595                 600                 605             


Val Tyr Gly Val Gln Arg Gly Ala Lys Lys Pro Leu Glu Arg Val Phe 
    610                 615                 620                 


Gln Phe Leu Glu Lys Ser Asp Leu Gly Cys Gly Ala Gly Gly Gly Leu 
625                 630                 635                 640 


Asn Asn Ala Asn Val Phe His Leu Ala Gly Leu Thr Phe Leu Thr Asn 
                645                 650                 655     


Ala Asn Ala Asp Asp Ser Gln Glu Asn Asp Glu Pro Cys Lys Glu Ile 
            660                 665                 670         


Leu Arg Pro Arg Arg Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala 
        675                 680                 685             


Lys Tyr Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys 
    690                 695                 700                 


Val Asn Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu 
705                 710                 715                 720 


Gly Pro Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser 
                725                 730                 735     


Gln Leu Arg Ala Asn Ile Ser His Lys Asp Met Gln Leu Gly Arg Leu 
            740                 745                 750         


His Met Lys Thr Leu Leu Pro Val Ser Lys Pro Glu Ile Arg Ser Tyr 
        755                 760                 765             


Phe Pro Glu Ser Trp Leu Trp Glu Val His Leu Val Pro Arg Arg Lys 
    770                 775                 780                 


Gln Leu Gln Phe Ala Leu Pro Asp Ser Leu Thr Thr Trp Glu Ile Gln 
785                 790                 795                 800 


Gly Val Gly Ile Ser Asn Thr Gly Ile Cys Val Ala Asp Thr Val Lys 
                805                 810                 815     


Ala Lys Val Phe Lys Asp Val Phe Leu Glu Met Asn Ile Pro Tyr Ser 
            820                 825                 830         


Val Val Arg Gly Glu Gln Ile Gln Leu Lys Gly Thr Val Tyr Asn Tyr 
        835                 840                 845             


Arg Thr Ser Gly Met Gln Phe Cys Val Lys Met Ser Ala Val Glu Gly 
    850                 855                 860                 


Ile Cys Thr Ser Glu Ser Pro Val Ile Asp His Gln Gly Thr Lys Ser 
865                 870                 875                 880 


Ser Lys Cys Val Arg Gln Lys Val Glu Gly Ser Ser Ser His Leu Val 
                885                 890                 895     


Thr Phe Thr Val Leu Pro Leu Glu Ile Gly Leu His Asn Ile Asn Phe 
            900                 905                 910         


Ser Leu Glu Thr Trp Phe Gly Lys Glu Ile Leu Val Lys Thr Leu Arg 
        915                 920                 925             


Val Val Pro Glu Gly Val Lys Arg Glu Ser Tyr Ser Gly Val Thr Leu 
    930                 935                 940                 


Asp Pro Arg Gly Ile Tyr Gly Thr Ile Ser Arg Arg Lys Glu Phe Pro 
945                 950                 955                 960 


Tyr Arg Ile Pro Leu Asp Leu Val Pro Lys Thr Glu Ile Lys Arg Ile 
                965                 970                 975     


Leu Ser Val Lys Gly Leu Leu Val Gly Glu Ile Leu Ser Ala Val Leu 
            980                 985                 990         


Ser Gln Glu Gly Ile Asn Ile Leu  Thr His Leu Pro Lys  Gly Ser Ala 
        995                 1000                 1005             


Glu Ala  Glu Leu Met Ser Val  Val Pro Val Phe Tyr  Val Phe His 
    1010                 1015                 1020             


Tyr Leu  Glu Thr Gly Asn His  Trp Asn Ile Phe His  Ser Asp Pro 
    1025                 1030                 1035             


Leu Ile  Glu Lys Gln Lys Leu  Lys Lys Lys Leu Lys  Glu Gly Met 
    1040                 1045                 1050             


Leu Ser  Ile Met Ser Tyr Arg  Asn Ala Asp Tyr Ser  Tyr Ser Val 
    1055                 1060                 1065             


Trp Lys  Gly Gly Ser Ala Ser  Thr Trp Leu Thr Ala  Phe Ala Leu 
    1070                 1075                 1080             


Arg Val  Leu Gly Gln Val Asn  Lys Tyr Val Glu Gln  Asn Gln Asn 
    1085                 1090                 1095             


Ser Ile  Cys Asn Ser Leu Leu  Trp Leu Val Glu Asn  Tyr Gln Leu 
    1100                 1105                 1110             


Asp Asn  Gly Ser Phe Lys Glu  Asn Ser Gln Tyr Gln  Pro Ile Lys 
    1115                 1120                 1125             


Leu Gln  Gly Thr Leu Pro Val  Glu Ala Arg Glu Asn  Ser Leu Tyr 
    1130                 1135                 1140             


Leu Thr  Ala Phe Thr Val Ile  Gly Ile Arg Lys Ala  Phe Asp Ile 
    1145                 1150                 1155             


Cys Pro  Leu Val Lys Ile Asp  Thr Ala Leu Ile Lys  Ala Asp Asn 
    1160                 1165                 1170             


Phe Leu  Leu Glu Asn Thr Leu  Pro Ala Gln Ser Thr  Phe Thr Leu 
    1175                 1180                 1185             


Ala Ile  Ser Ala Tyr Ala Leu  Ser Leu Gly Asp Lys  Thr His Pro 
    1190                 1195                 1200             


Gln Phe  Arg Ser Ile Val Ser  Ala Leu Lys Arg Glu  Ala Leu Val 
    1205                 1210                 1215             


Lys Gly  Asn Pro Pro Ile Tyr  Arg Phe Trp Lys Asp  Asn Leu Gln 
    1220                 1225                 1230             


His Lys  Asp Ser Ser Val Pro  Asn Thr Gly Thr Ala  Arg Met Val 
    1235                 1240                 1245             


Glu Thr  Thr Ala Tyr Ala Leu  Leu Thr Ser Leu Asn  Leu Lys Asp 
    1250                 1255                 1260             


Ile Asn  Tyr Val Asn Pro Val  Ile Lys Trp Leu Ser  Glu Glu Gln 
    1265                 1270                 1275             


Arg Tyr  Gly Gly Gly Phe Tyr  Ser Thr Gln Asp Thr  Ile Asn Ala 
    1280                 1285                 1290             


Ile Glu  Gly Leu Thr Glu Tyr  Ser Leu Leu Val Lys  Gln Leu Arg 
    1295                 1300                 1305             


Leu Ser  Met Asp Ile Asp Val  Ser Tyr Lys His Lys  Gly Ala Leu 
    1310                 1315                 1320             


His Asn  Tyr Lys Met Thr Asp  Lys Asn Phe Leu Gly  Arg Pro Val 
    1325                 1330                 1335             


Glu Val  Leu Leu Asn Asp Asp  Leu Ile Val Ser Thr  Gly Phe Gly 
    1340                 1345                 1350             


Ser Gly  Leu Ala Thr Val His  Val Thr Thr Val Val  His Lys Thr 
    1355                 1360                 1365             


Ser Thr  Ser Glu Glu Val Cys  Ser Phe Tyr Leu Lys  Ile Asp Thr 
    1370                 1375                 1380             


Gln Asp  Ile Glu Ala Ser His  Tyr Arg Gly Tyr Gly  Asn Ser Asp 
    1385                 1390                 1395             


Tyr Lys  Arg Ile Val Ala Cys  Ala Ser Tyr Lys Pro  Ser Arg Glu 
    1400                 1405                 1410             


Glu Ser  Ser Ser Gly Ser Ser  His Ala Val Met Asp  Ile Ser Leu 
    1415                 1420                 1425             


Pro Thr  Gly Ile Ser Ala Asn  Glu Glu Asp Leu Lys  Ala Leu Val 
    1430                 1435                 1440             


Glu Gly  Val Asp Gln Leu Phe  Thr Asp Tyr Gln Ile  Lys Asp Gly 
    1445                 1450                 1455             


His Val  Ile Leu Gln Leu Asn  Ser Ile Pro Ser Ser  Asp Phe Leu 
    1460                 1465                 1470             


Cys Val  Arg Phe Arg Ile Phe  Glu Leu Phe Glu Val  Gly Phe Leu 
    1475                 1480                 1485             


Ser Pro  Ala Thr Phe Thr Val  Tyr Glu Tyr His Arg  Pro Asp Lys 
    1490                 1495                 1500             


Gln Cys  Thr Met Phe Tyr Ser  Thr Ser Asn Ile Lys  Ile Gln Lys 
    1505                 1510                 1515             


Val Cys  Glu Gly Ala Ala Cys  Lys Cys Val Glu Ala  Asp Cys Gly 
    1520                 1525                 1530             


Gln Met  Gln Glu Glu Leu Asp  Leu Thr Ile Ser Ala  Glu Thr Arg 
    1535                 1540                 1545             


Lys Gln  Thr Ala Cys Lys Pro  Glu Ile Ala Tyr Ala  Tyr Lys Val 
    1550                 1555                 1560             


Ser Ile  Thr Ser Ile Thr Val  Glu Asn Val Phe Val  Lys Tyr Lys 
    1565                 1570                 1575             


Ala Thr  Leu Leu Asp Ile Tyr  Lys Thr Gly Glu Ala  Val Ala Glu 
    1580                 1585                 1590             


Lys Asp  Ser Glu Ile Thr Phe  Ile Lys Lys Val Thr  Cys Thr Asn 
    1595                 1600                 1605             


Ala Glu  Leu Val Lys Gly Arg  Gln Tyr Leu Ile Met  Gly Lys Glu 
    1610                 1615                 1620             


Ala Leu  Gln Ile Lys Tyr Asn  Phe Ser Phe Arg Tyr  Ile Tyr Pro 
    1625                 1630                 1635             


Leu Asp  Ser Leu Thr Trp Ile  Glu Tyr Trp Pro Arg  Asp Thr Thr 
    1640                 1645                 1650             


Cys Ser  Ser Cys Gln Ala Phe  Leu Ala Asn Leu Asp  Glu Phe Ala 
    1655                 1660                 1665             


Glu Asp  Ile Phe Leu Asn Gly  Cys 
    1670                 1675     


<210>  1431
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5orf22__Homo_sapiens__NP_060826

<400>  1431

Met Ser Asp Ser Ala Gly Gly Arg Ala Gly Leu Arg Arg Tyr Pro Lys 
1               5                   10                  15      


Leu Pro Val Trp Val Val Glu Asp His Gln Glu Val Leu Pro Phe Ile 
            20                  25                  30          


Tyr Arg Ala Ile Gly Ser Lys His Leu Pro Ala Ser Asn Val Ser Phe 
        35                  40                  45              


Leu His Phe Asp Ser His Pro Asp Leu Leu Ile Pro Val Asn Met Pro 
    50                  55                  60                  


Ala Asp Thr Val Phe Asp Lys Glu Thr Leu Phe Gly Glu Leu Ser Ile 
65                  70                  75                  80  


Glu Asn Trp Ile Met Pro Ala Val Tyr Ala Gly His Phe Ser His Val 
                85                  90                  95      


Ile Trp Phe His Pro Thr Trp Ala Gln Gln Ile Arg Glu Gly Arg His 
            100                 105                 110         


His Phe Leu Val Gly Lys Asp Thr Ser Thr Thr Thr Ile Arg Val Thr 
        115                 120                 125             


Ser Thr Asp His Tyr Phe Leu Ser Asp Gly Leu Tyr Val Pro Glu Asp 
    130                 135                 140                 


Gln Leu Glu Asn Gln Lys Pro Leu Gln Leu Asp Val Ile Met Val Lys 
145                 150                 155                 160 


Pro Tyr Lys Leu Cys Asn Asn Gln Glu Glu Asn Asp Ala Val Ser Ser 
                165                 170                 175     


Ala Lys Lys Pro Lys Leu Ala Leu Glu Asp Ser Glu Asn Thr Ala Ser 
            180                 185                 190         


Thr Asn Cys Asp Ser Ser Ser Glu Gly Leu Glu Lys Asp Thr Ala Thr 
        195                 200                 205             


Gln Arg Ser Asp Gln Thr Cys Leu Glu Pro Ser Cys Ser Cys Ser Ser 
    210                 215                 220                 


Glu Asn Gln Glu Cys Gln Thr Ala Ala Ser Thr Gly Glu Ile Leu Glu 
225                 230                 235                 240 


Ile Leu Lys Lys Gly Lys Ala Phe Val Leu Asp Ile Asp Leu Asp Phe 
                245                 250                 255     


Phe Ser Val Lys Asn Pro Phe Lys Glu Met Phe Thr Gln Glu Glu Tyr 
            260                 265                 270         


Lys Ile Leu Gln Glu Leu Tyr Gln Phe Lys Lys Pro Gly Thr Asn Leu 
        275                 280                 285             


Thr Glu Glu Asp Leu Val Asp Ile Val Asp Thr Arg Ile His Gln Leu 
    290                 295                 300                 


Glu Asp Leu Glu Ala Thr Phe Ala Asp Leu Cys Asp Gly Asp Asp Glu 
305                 310                 315                 320 


Glu Thr Val Gln Arg Trp Ala Ser Asn Pro Gly Met Glu Ser Leu Val 
                325                 330                 335     


Pro Leu Val Gln Ser Leu Lys Lys Arg Met Glu Val Pro Asp Tyr Glu 
            340                 345                 350         


Met Val His Gln Ala Gly Leu Thr Cys Asp Tyr Ser Glu Leu Pro His 
        355                 360                 365             


His Ile Ser Thr Glu Gln Glu Ile Glu Cys Leu Ile Gln Ser Val His 
    370                 375                 380                 


Tyr Leu Leu Lys Asn Leu Pro Asn Pro Thr Leu Val Thr Ile Ala Arg 
385                 390                 395                 400 


Ser Ser Leu Asp Asp Tyr Cys Pro Ser Asp Gln Val Asp Thr Ile Gln 
                405                 410                 415     


Glu Lys Val Leu Asn Met Leu Arg Ala Leu Tyr Gly Asn Leu Asp Leu 
            420                 425                 430         


Gln Val Tyr Ala Ala Glu Ser Pro Pro Ser 
        435                 440         


<210>  1432
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5orf30__Homo_sapiens__NP_149988

<400>  1432

Met Glu Val Asp Ile Asn Gly Glu Ser Arg Ser Thr Leu Thr Thr Leu 
1               5                   10                  15      


Pro Phe Pro Gly Ala Glu Ala Asn Ser Pro Gly Lys Ala Glu Ala Glu 
            20                  25                  30          


Lys Pro Arg Cys Ser Ser Thr Pro Cys Ser Pro Met Arg Arg Thr Val 
        35                  40                  45              


Ser Gly Tyr Gln Ile Leu His Met Asp Ser Asn Tyr Leu Val Gly Phe 
    50                  55                  60                  


Thr Thr Gly Glu Glu Leu Leu Lys Leu Ala Gln Lys Cys Thr Gly Gly 
65                  70                  75                  80  


Glu Glu Ser Lys Ala Glu Ala Met Pro Ser Leu Arg Ser Lys Gln Leu 
                85                  90                  95      


Asp Ala Gly Leu Ala Arg Ser Ser Arg Leu Tyr Lys Thr Arg Ser Arg 
            100                 105                 110         


Tyr Tyr Gln Pro Tyr Glu Ile Pro Ala Val Asn Gly Arg Arg Arg Arg 
        115                 120                 125             


Arg Met Pro Ser Ser Gly Asp Lys Cys Thr Lys Ser Leu Pro Tyr Glu 
    130                 135                 140                 


Pro Tyr Lys Ala Leu His Gly Pro Leu Pro Leu Cys Leu Leu Lys Gly 
145                 150                 155                 160 


Lys Arg Ala His Ser Lys Ser Leu Asp Tyr Leu Asn Leu Asp Lys Met 
                165                 170                 175     


Ile Lys Glu Pro Ala Asp Thr Glu Val Leu Gln Tyr Gln Leu Gln His 
            180                 185                 190         


Leu Thr Leu Arg Gly Asp Arg Val Phe Ala Arg Asn Asn Thr 
        195                 200                 205     


<210>  1433
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5orf34__Homo_sapiens__NP_940968

<400>  1433

Met Ala Ala Glu Leu Arg Met Ile Leu Tyr Glu Asp Asp Ser Val Gln 
1               5                   10                  15      


Val Gln Tyr Val Asp Gly Ser Thr Leu Gln Leu Ser Pro Cys Gly Ser 
            20                  25                  30          


Glu Phe Leu Phe Glu Lys Ser Pro Pro Val Ser Ala His Pro Leu Glu 
        35                  40                  45              


Gln Pro Glu Arg Ile Arg Gln Arg Thr His Phe Val Ile Ser Thr Tyr 
    50                  55                  60                  


Arg Glu Gln Leu Gln Arg Ala Leu Asp Phe Arg Asn Ser Ser Ala Thr 
65                  70                  75                  80  


Cys Pro Phe Leu Ser Glu Thr Ile Ile Pro Ser Glu Arg Lys Lys His 
                85                  90                  95      


Ile Phe Ile Asp Ile Thr Glu Val Arg Trp Pro Ser Leu Asp Thr Asp 
            100                 105                 110         


Gly Thr Met Ile Tyr Met Glu Ser Gly Ile Val Lys Ile Thr Ser Leu 
        115                 120                 125             


Asp Gly His Ala Tyr Leu Cys Leu Pro Arg Ser Gln His Glu Phe Thr 
    130                 135                 140                 


Val His Phe Leu Cys Lys Val Ser Gln Lys Ser Asp Ser Ser Ala Val 
145                 150                 155                 160 


Leu Ser Glu Thr Asn Asn Lys Ala Pro Lys Asp Lys Leu Val Glu Lys 
                165                 170                 175     


Thr Gly Lys Ile Cys Ile Arg Gly Asn Leu Pro Gly Gln Arg Leu Lys 
            180                 185                 190         


Asn Lys Glu Asn Glu Phe His Cys Gln Ile Met Lys Ser Lys Glu Thr 
        195                 200                 205             


Leu Lys Lys Met Ser Cys Val Asn Gly Thr Glu Gly Arg Glu Glu Leu 
    210                 215                 220                 


Pro Ser Pro Gly Thr Lys His Thr Cys Val Tyr Thr Trp Val Lys Gln 
225                 230                 235                 240 


Cys Trp Ser Val Ala Ala Cys Pro Glu Glu Trp Lys Tyr Pro Leu Ser 
                245                 250                 255     


Leu Ala Leu His Phe His Asn Lys Ile Ser Asn Met Ser Lys Ile Asp 
            260                 265                 270         


Ala His Ile Thr Gln Ser Arg Phe Leu Thr Ser Asp Ile Ser Glu Glu 
        275                 280                 285             


Arg Gly Lys Val Val Ser Val Leu Pro Arg Ala Leu Ser Leu Ser Cys 
    290                 295                 300                 


Pro Val Pro His Leu His Arg Trp Asn Phe Cys Asp Ser Leu Leu Gln 
305                 310                 315                 320 


Arg Gln Ser Asp Glu Tyr Ser Tyr Pro Glu Leu Val Lys Met Val Trp 
                325                 330                 335     


Tyr Lys Gly Val Thr Tyr Arg Leu Thr His Gln Asn Met Asn Ser Ile 
            340                 345                 350         


Glu Ile Tyr Ser Gly Asp Gly Ser Val Phe Lys Ser Glu Gly Ala Tyr 
        355                 360                 365             


Phe Gly Asn Tyr Phe Thr Tyr Tyr Ser Ile Gln Glu Gly Ser Gly Lys 
    370                 375                 380                 


Arg Glu Glu Lys Thr Tyr Ser Val Asn Asn Leu Pro Pro Asp Arg Pro 
385                 390                 395                 400 


Gly Ser Pro Phe Thr Val Gly Ser Leu Ile Lys Gln Ala Thr Arg Ile 
                405                 410                 415     


Leu Gln His Cys Val Lys Met Arg Leu Ser Leu Ser His Asn Tyr Arg 
            420                 425                 430         


Ile Cys Cys Trp Lys Met Val Pro Gly Ile Asn Asp Ser Asn Ile Leu 
        435                 440                 445             


Pro Leu Val Leu Lys Glu Ser Leu Ile Pro Ser Val Gly Arg Phe Leu 
    450                 455                 460                 


Ala Tyr Ser Asp Asp Lys Val His Ala Ile Phe Leu Asp Gly Ile Thr 
465                 470                 475                 480 


Leu Thr Leu Asn Trp Asn Phe Ser Ser Pro Ile Glu Lys Arg Gln Val 
                485                 490                 495     


Asn Gln Gly Leu Asn Leu Gly Trp Cys Lys Leu Thr Phe Pro Asp Gly 
            500                 505                 510         


Gln Glu Gln Leu Ile Gln Ile Glu His Pro Glu Pro Tyr Glu Arg Tyr 
        515                 520                 525             


Val Thr Thr Val Thr Ser Trp Cys Arg Arg Leu Thr Gln Thr Ser Pro 
    530                 535                 540                 


Arg Glu Met Pro Thr His Ser Ser Ser Ser Val Leu Gln Glu Asn Trp 
545                 550                 555                 560 


Ser Val Ala Ser Glu Leu Glu Lys Ile Gln Lys Phe Asn Leu Leu Leu 
                565                 570                 575     


Glu Asn Ser Gly Ile Leu Asn Gln Ile Ser Asn Lys Lys Asn Glu Gln 
            580                 585                 590         


Gln Ser Phe Asp His Tyr Lys Pro Gly Ser Ser Glu Thr Leu Leu Gly 
        595                 600                 605             


Glu Val Asn Glu Asn Arg Val Ser Ile Ala Leu Lys Lys Thr Ser Glu 
    610                 615                 620                 


Ile Leu His Asp Ile Asp Cys Leu Leu Ser Asn Ser Lys Lys 
625                 630                 635             


<210>  1434
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5orf38__Homo_sapiens__NP_001281266

<400>  1434

Met Val Ala Pro Ala Ala Arg Val Phe Leu Arg Ala Val Arg Ala Ala 
1               5                   10                  15      


Leu Thr Ser Thr Val Pro Asp Leu Leu Cys Leu Leu Ala Arg Gly Ser 
            20                  25                  30          


Pro Arg Gly Leu Ala Ser Gly Arg Leu Pro Leu Ala Val His Ser Ala 
        35                  40                  45              


Gln His Gly Pro Gly Ser Gly Ala Pro Trp Leu Arg Ile Ala Arg Arg 
    50                  55                  60                  


Ala Leu Ser Gln Arg Ile 
65                  70  


<210>  1435
<211>  3197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5orf42__Homo_sapiens__NP_075561

<400>  1435

Met Glu Ile Arg Leu Glu Ile Leu Thr Ser Thr Gly Ile Lys Gln Lys 
1               5                   10                  15      


Lys Pro Trp Pro Arg Val Ser Trp Leu Gly Lys Glu Lys Glu Ala Val 
            20                  25                  30          


Phe Leu Leu Asp Asp Lys Phe Ile Asn Glu Ile Asn Leu Leu Ser Gly 
        35                  40                  45              


Lys Ile Lys Lys Lys Ile Pro Ser Leu Gln Pro Phe Leu Lys Asp Val 
    50                  55                  60                  


Ile Val Leu Thr Thr Ser Ser Asn Asp Ala Trp Leu Ala Gly Val Leu 
65                  70                  75                  80  


Thr Thr Gly Glu Leu Phe Leu Trp Asn Lys Asp Gln Asp Cys Leu Lys 
                85                  90                  95      


Thr Ile Pro Ile Thr Glu Lys Pro Lys Glu Met Ile Lys Ala Thr Val 
            100                 105                 110         


Ala Ser Ser Leu Arg Leu Tyr Leu Tyr Val Ser Gly Asn Gly Lys Arg 
        115                 120                 125             


Ile Val Leu Ile Thr Pro Ser Gly Cys Ile Phe Leu Trp Glu Tyr Leu 
    130                 135                 140                 


Glu Leu Lys Asn Ile Leu Ser Ser Lys Ser Leu Ser Leu Ala Gly Arg 
145                 150                 155                 160 


Trp Ser Gln Val Ile Pro Glu Glu Ala Val Leu Leu Pro Ser Thr Glu 
                165                 170                 175     


Asp Lys Glu Ala Val Val Asn Ala Val Phe Ile Lys Asn Glu Leu Phe 
            180                 185                 190         


Gly Asp Cys Cys Leu Cys Ser Phe Thr Phe Tyr Ser Gly Glu Cys Leu 
        195                 200                 205             


Lys Leu Thr Phe Leu Ala Ile Arg Trp His Glu Asn Val Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Leu Pro Tyr His Val His Trp Ala Gln Gln Asp Cys His 
225                 230                 235                 240 


Leu Cys Ser Leu Ile Pro Lys Cys Glu Ser Val Lys Ser Arg Gly Ala 
                245                 250                 255     


Leu Ile Ser Ala Phe Ser Arg Asp Gly Leu Thr Leu Ala Val Thr Leu 
            260                 265                 270         


Asn Gln Lys Asp Pro Lys Ala Thr Gln Val Leu Phe Ile Asn Thr Leu 
        275                 280                 285             


Asn Phe Val Thr Leu Cys Gly Ser Leu Lys Gly Cys Ser Asn Lys Ser 
    290                 295                 300                 


Pro Val Val Pro Ala Thr Leu Ile Arg Ser Tyr Trp Val Gly Asp Ile 
305                 310                 315                 320 


Ser Trp Thr His Asp Ser Leu Phe Leu Ala Cys Met Leu Lys Arg Gly 
                325                 330                 335     


Ser Leu Val Leu Leu Thr Cys Gln Gly Glu Leu Leu Thr Leu Ile Thr 
            340                 345                 350         


Phe Gly Cys Ser Ile Glu Phe Gly Pro Ala Glu Phe Ile Pro Leu His 
        355                 360                 365             


Pro Leu Ile Thr Tyr Arg Pro Gln Gln Phe Thr Phe Gln Asp Ser Asn 
    370                 375                 380                 


Asn Ser Val Asp Ser Ser Ala Ser Asp Ser Asp Pro Met Arg Gln Arg 
385                 390                 395                 400 


Phe Ser Ile Lys Ala His Ser Arg Leu Pro Tyr Leu Val Ile Ser Asp 
                405                 410                 415     


Gly Tyr Met Val Thr Thr Leu Arg Phe Leu Asp Ser Leu Ser Pro Ser 
            420                 425                 430         


Val His Met Arg Ser Leu Leu Leu Asp Ser Thr Gln Arg Leu Glu Lys 
        435                 440                 445             


Ile Tyr Gln Ser Val Ile Leu Ser Lys Pro Lys Gly Lys Gly Leu Asn 
    450                 455                 460                 


Leu Arg Ser Leu Asn Ser Leu Arg Ser Ser Leu Leu Glu His Gln Gly 
465                 470                 475                 480 


Asn Glu Ser Ser Ala Asp Phe Thr Val Pro Lys Phe Leu Gln Ala Glu 
                485                 490                 495     


Glu Thr Ile Asn Glu Asn Ala Ala Asp Phe Gln Asp Phe Glu Ala Glu 
            500                 505                 510         


Glu Thr Asn Glu Gly Arg His Phe Pro Asp Asn Leu Cys Pro Phe Trp 
        515                 520                 525             


Asn Lys Arg Asp Asp Val Leu Cys Ser Ser Met Lys Glu Gly Arg Leu 
    530                 535                 540                 


Glu Phe Ala Ser Met Phe Asp Thr Ile His Ala Lys Asp Asp Ser Glu 
545                 550                 555                 560 


Glu Thr Asp Arg Thr Ile Thr Glu Leu His Ser Ile Gln Lys Ser Leu 
                565                 570                 575     


Leu Ala Ala Trp Thr Ile Gly Ile Ser Lys Thr Val Thr Glu Lys Asn 
            580                 585                 590         


Leu Met Leu Asn Tyr Ile Val Val Cys Ile Thr His Phe Phe Tyr Ile 
        595                 600                 605             


Leu Gln Phe Ile Lys Cys Pro Phe Pro Lys Leu Asp Leu Val Leu Ser 
    610                 615                 620                 


Lys Ser Ser Arg His Asn Ala Trp Ile Leu Cys Ile Phe Gln Leu Phe 
625                 630                 635                 640 


His Gln Cys Leu Ser Ile His Tyr Trp Asp Ile Arg Tyr Lys Gln Asp 
                645                 650                 655     


Val Gly His Leu Ile Lys Leu Thr Ser Asn Thr Val Lys Leu Leu Leu 
            660                 665                 670         


Thr Gln Gln Gln Lys Gly Gln Leu Phe Ser Glu Lys Leu Leu Ala Cys 
        675                 680                 685             


Phe Tyr Leu Leu Lys Met Val Ala Asp Asn Leu Asn Gly Val Tyr Ile 
    690                 695                 700                 


Leu Gln Pro Glu Val Ile Ser Ala Ser Ala Asp Gly Ser Lys Ile Thr 
705                 710                 715                 720 


Ala Gln Asp Ser Leu Val Val Pro Ile Phe Gln Met Phe Gln Asp Ser 
                725                 730                 735     


Gly Phe Gln Lys Asn Trp Ser Trp Asn Ser Phe Phe Lys Ile His Pro 
            740                 745                 750         


Gln Val Val Asn Pro Val Gln Gln Pro Gly His Arg Leu Leu Ile Leu 
        755                 760                 765             


Trp Arg Ile Leu Tyr Lys Lys Thr Leu Trp Tyr Gln Ala Gln Leu Asn 
    770                 775                 780                 


Arg Arg Val Pro Glu Ala Asp Ser Gln Leu Thr Glu Lys Met Thr His 
785                 790                 795                 800 


Glu Ala Ser Thr Val Lys Ser Leu Leu Cys His Leu Gln Ala Asn Leu 
                805                 810                 815     


Gln Ser Thr Gly Asp Cys Leu Asn Gln Thr Leu Glu Leu Lys Ser Ile 
            820                 825                 830         


Asn Gly Glu Glu Cys Phe Leu Leu Gly Ser Tyr Glu Lys Ser Val Gln 
        835                 840                 845             


Leu Trp Lys Lys Ala Leu Gln Glu Ile Glu Glu Lys Gly Gly Arg Arg 
    850                 855                 860                 


Thr Tyr Phe Leu Gln Ile Arg Tyr Tyr Leu Ser Leu Leu Tyr Cys His 
865                 870                 875                 880 


Leu Tyr Ser Tyr Asn Leu Asn Asp Ala Gln Gly Leu Cys Asp Gln Leu 
                885                 890                 895     


Ala Arg Glu Ile Leu Arg Trp Ser Gln Leu Pro Val Lys Glu Asn Lys 
            900                 905                 910         


Asp Phe Ser Gly Ala Ala Lys Ser His Phe Glu Cys Gly Met Val Gly 
        915                 920                 925             


Gly Val His Pro Glu Ala Ala Val Arg Val Val Gln Ser Met Ala Arg 
    930                 935                 940                 


Phe Met Ala Ala Tyr Phe Thr Asn Gln Gln Leu Cys Ile Leu Pro Pro 
945                 950                 955                 960 


His His Val Asn Val Leu Pro Pro Leu His Ile Lys Thr Glu Gln Ser 
                965                 970                 975     


Phe Arg Leu Ile Pro Leu Gln His Ser Lys Val Ala Ser Val Val Arg 
            980                 985                 990         


Asp Gln Asn Leu Ser Asn Val Trp  Thr Val Glu Tyr Ala  Leu Glu Leu 
        995                 1000                 1005             


Leu Phe  Ile Gly Gly Leu Val  Pro Glu Ala Val Trp  Leu Ala Tyr 
    1010                 1015                 1020             


Lys Leu  Gly Asp Trp Lys Thr  Ser Val Ser Ile Gly  Val Ala Phe 
    1025                 1030                 1035             


Gln Leu  Phe Cys Lys Arg Asp  Ser Asn Phe Met Arg  Ser Lys Lys 
    1040                 1045                 1050             


Lys Ser  Leu Asn Leu Pro Leu  Arg Met Thr Pro Ala  Gln Ile Phe 
    1055                 1060                 1065             


Gln Glu  Lys Leu Gln Cys Val  Leu Gly Gln Pro Ala  Ser Leu Glu 
    1070                 1075                 1080             


Ala Lys  Asn Glu Met Gly Ser  Lys Tyr Lys Gln Phe  Thr Asp Pro 
    1085                 1090                 1095             


Ile Glu  Glu Glu Asp Ala Asn  Leu Leu Phe Gly Ser  Val Gln Glu 
    1100                 1105                 1110             


Val Leu  Lys Ala Ser Val Met  Ala Asp Ala Asp Ile  Leu Ser Glu 
    1115                 1120                 1125             


Thr Phe  Gln Leu Leu Ile Asp  Ser Ala Lys Asp Phe  Ser Lys Arg 
    1130                 1135                 1140             


Leu Trp  Gly Leu Val Pro Phe  Gly Leu Tyr Leu Pro  Ala Pro Pro 
    1145                 1150                 1155             


Leu Tyr  Cys Pro Gln Pro Ala  Ile Leu Ser Glu Glu  Asp Gly Asp 
    1160                 1165                 1170             


Asp Leu  Leu Leu Lys Ala Glu  Lys Asn Asn Arg Gln  Lys Val Ser 
    1175                 1180                 1185             


Gly Ile  Leu Gln Arg Val Leu  Leu Leu Phe Arg Ala  Ala Gln Cys 
    1190                 1195                 1200             


Ser Phe  Pro Val Ala Gln Trp  Tyr Ile Leu Gln Leu  Arg Trp Ala 
    1205                 1210                 1215             


Arg Lys  Val Met Gln Lys Ile  Arg Met Lys Gly Ser  Leu Pro Ser 
    1220                 1225                 1230             


Leu Ser  Pro Phe Pro Gln Ser  Leu Leu Asn Tyr Cys  Lys Gly Gly 
    1235                 1240                 1245             


Ile Ala  Phe Phe Arg Pro Gly  Ala Ala Gly Asp His  Lys Leu Asp 
    1250                 1255                 1260             


Glu Val  Ser Ile Arg Ala Ile  Gly Cys Phe Arg Glu  Leu Cys Ala 
    1265                 1270                 1275             


Leu Cys  Trp Met Leu His Val  Arg Asp Lys Leu Ser  Tyr Ser Cys 
    1280                 1285                 1290             


Arg Gln  Tyr Gln Lys Ala Arg  Glu Asn Val Lys Gly  Glu Lys Asp 
    1295                 1300                 1305             


Leu Glu  Val Glu Phe Asp Ser  Cys Met Ile Glu His  Cys Leu Ser 
    1310                 1315                 1320             


Ala Val  Glu Trp Ala Tyr Arg  Met Leu Pro Phe Ser  Arg Phe Phe 
    1325                 1330                 1335             


Asn Met  Glu Glu Leu Ile Gln  Asp Ile Ile Leu Ser  Leu Ile Gly 
    1340                 1345                 1350             


Glu Leu  Pro Pro Ile Arg Lys  Val Ala Glu Ile Phe  Val Lys Ala 
    1355                 1360                 1365             


Phe Pro  Tyr Pro Glu Asp Val  Arg Val Pro Leu Arg  Asp Lys Tyr 
    1370                 1375                 1380             


His Ser  Leu His Gln Arg Leu  Arg His Cys Val Val  Lys Gly Pro 
    1385                 1390                 1395             


Gln Thr  Glu Glu Met Met Ser  Val Val Met His Ser  Ile Gln Lys 
    1400                 1405                 1410             


Val Arg  Val Lys Ala Leu Lys  Arg Val Gln Arg Asn  Ile Gly Ser 
    1415                 1420                 1425             


Phe Glu  Val Asn Ile Trp Glu  Pro Ile Glu Glu Glu  Lys Pro Asp 
    1430                 1435                 1440             


Glu Ala  Pro Gly Val Asp Arg  Tyr Ser Leu Gly Thr  Ser Leu Ser 
    1445                 1450                 1455             


Arg Ser  Thr Leu Thr Glu Leu  Gly Asp Ser Val Val  His Ser Asp 
    1460                 1465                 1470             


Ala Asp  Thr Phe Ser Glu Ala  Leu Ser Val Glu Glu  Lys Ser Arg 
    1475                 1480                 1485             


Ile Asn  Ile Tyr Gln Arg Asn  Ala Pro Asn His Met  Glu Leu Thr 
    1490                 1495                 1500             


Ser Ile  His Lys Pro Thr Asp  Lys Arg Lys Met Cys  Asn Gln Lys 
    1505                 1510                 1515             


Glu Asn  Pro Thr Lys Lys Glu  Asp His Glu Lys Leu  Ser Gln Asn 
    1520                 1525                 1530             


Thr Leu  Pro Val Ile Gly Val  Trp Glu Phe Glu Arg  Asp Asp Asp 
    1535                 1540                 1545             


Glu Tyr  Ile Lys Phe Leu Asp  Leu Phe Leu Ser Tyr  Ile Leu Glu 
    1550                 1555                 1560             


Arg Asp  Leu Pro Tyr Ser Arg  Asp Ala Asp Ile Pro  Phe Leu Thr 
    1565                 1570                 1575             


Ser Phe  Ser Gly Lys Leu Arg  Glu His Glu Leu Asn  Ser Leu Leu 
    1580                 1585                 1590             


Phe Asp  Val His Thr Thr Leu  Lys Arg His Gln Ser  Lys Thr Lys 
    1595                 1600                 1605             


Ser Gln  Asn Val Phe Arg Ala  Gly Ser Cys Phe Val  Val Ala Pro 
    1610                 1615                 1620             


Glu Ser  Tyr Glu Ser Glu Lys  Ser Ser Ser Leu Asn  Asp Glu Tyr 
    1625                 1630                 1635             


Gly Met  His Leu Glu Asn Gln  Lys Leu Ser Ser Ser  Val Leu Val 
    1640                 1645                 1650             


Asn Gln  Gly Ile Lys Pro Phe  Leu Gln Tyr Pro Ser  Asn Glu Val 
    1655                 1660                 1665             


Asn Lys  Asn Glu Gly Met Ser  Gly Leu Phe Gly Leu  Lys Gln Arg 
    1670                 1675                 1680             


Ser Ile  Tyr Lys Ile Gln Asp  Asp Thr Arg Glu Lys  Cys Leu Ile 
    1685                 1690                 1695             


Gln Arg  Ser Ser Asn His Ile  Phe Trp Thr Pro Lys  Ser Ile Lys 
    1700                 1705                 1710             


Thr Arg  Arg Cys Ile Phe Lys  Ala Ile Gln Cys Asn  Asp Ile Asn 
    1715                 1720                 1725             


Pro Gln  Glu Asp Leu Pro Leu  Ala Leu Asn Thr Phe  Gly Ser Ile 
    1730                 1735                 1740             


Gly Arg  Leu Leu Glu Trp Met  Ile Arg Trp Ser Asn  Arg Arg Leu 
    1745                 1750                 1755             


Leu Cys  Asp Ser Gly Ile Thr  Glu Ser Ser Ser Glu  Tyr Ser Pro 
    1760                 1765                 1770             


Val Ile  Arg Val Lys Thr Ser  Thr Ala Ala Ile Leu  Thr Ser Leu 
    1775                 1780                 1785             


Trp Leu  Leu Glu Gln Pro Tyr  Phe Ala Thr Tyr Lys  Ala Lys Asn 
    1790                 1795                 1800             


Ala Ile  Ile Lys Met Val Glu  Asn Arg Asp Thr Gly  Cys Gln Ile 
    1805                 1810                 1815             


Gly Pro  Asn Ile Glu Arg Glu  Ser Lys Ser Asp Ala  Gly Gly Ser 
    1820                 1825                 1830             


Val Ala  Val Ala Thr Pro Gly  Gly Thr Glu Glu Arg  Asn Gly Gln 
    1835                 1840                 1845             


Asn Lys  Ser Cys Gln Asn Ile  Leu Asn Arg Met Pro  Thr Glu Ala 
    1850                 1855                 1860             


Lys Asn  Pro Asp Ile Lys Glu  Ile Asn Asp Asp Ile  Ile Ser Ile 
    1865                 1870                 1875             


Thr His  Asn Thr Lys Lys Glu  Phe Ile Asp Ile Asp  Glu Asn Leu 
    1880                 1885                 1890             


Leu Glu  Val Glu Ala Phe Thr  Glu Glu Glu Met Asp  Met His Ile 
    1895                 1900                 1905             


Ser Asp  Tyr Glu Glu Asp Ile  Glu Glu Ser Val Gly  Gly Phe Arg 
    1910                 1915                 1920             


Ser Pro  Ser Leu Ala Ile Cys  Met Met Thr Leu Pro  Gln Gln Leu 
    1925                 1930                 1935             


Glu Glu  Glu Phe Thr Glu Glu  Val Gln Cys Gln Arg  Glu Glu Pro 
    1940                 1945                 1950             


Leu Glu  Thr Ile Met Glu Glu  Lys Ser Thr Glu Gln  Lys Gly Met 
    1955                 1960                 1965             


Ile Glu  Ala Phe Ser His Pro  Gly His Thr Thr Pro  Gln Ser Met 
    1970                 1975                 1980             


Gln Val  Asp Thr Ser Ser Glu  Ile Ser Ser Ala Gln  Ile Ser Thr 
    1985                 1990                 1995             


Tyr Lys  Glu Lys Ser Ser Ser  Val Pro Leu Leu Ile  Ser Asn Gly 
    2000                 2005                 2010             


Val Asn  Val Ala Ser Gln Pro  Pro Ala Pro Thr Pro  Gln Lys Thr 
    2015                 2020                 2025             


Gln Arg  Asn Glu Phe Thr Ala  Gln Leu Pro Asp Cys  Ser Glu Ser 
    2030                 2035                 2040             


Val Arg  Gln Met Leu Gln Asp  Glu Met Phe Lys Leu  Val Gln Leu 
    2045                 2050                 2055             


Gln Gln  Ile Asn Phe Met Ser  Leu Met Gln Ile Val  Gly Ser Ser 
    2060                 2065                 2070             


Phe Ala  Asn Leu Pro Asp Thr  Gln Gln Leu Val Gln  Gln Ser Gln 
    2075                 2080                 2085             


Ser Val  His Leu Gly Glu Ser  Gln Glu Ser Asn Leu  Arg Gly Cys 
    2090                 2095                 2100             


Gly Asp  Val Glu Asp Ser Asn  Lys Asn Leu Lys Glu  Arg Phe Phe 
    2105                 2110                 2115             


Ile Lys  Pro Gln Ser Met Gly  Glu Asn Ala Arg Glu  Pro Arg Lys 
    2120                 2125                 2130             


Asn Ser  Pro His Cys His Glu  Gly Thr Ile Pro Ser  Gly Gln Asn 
    2135                 2140                 2145             


Ser Thr  Gly Asn Val Gln Asn  Val Pro His Gly Ser  Ile Pro Leu 
    2150                 2155                 2160             


Cys Gln  Leu Asn Gly Gln Pro  Arg Lys Lys Gly Pro  Ile Pro Ser 
    2165                 2170                 2175             


Ser Gln  Asn Leu Pro Ser Thr  Ser Phe Tyr Pro Ala  Pro Ala Gly 
    2180                 2185                 2190             


Asn Thr  His Leu Tyr Leu Leu  Ser Thr Pro Ser Val  Val Gln Lys 
    2195                 2200                 2205             


Ala Pro  Arg Leu Ile Pro His  Ala Lys Thr Phe Ser  Pro Gly Asp 
    2210                 2215                 2220             


Gly Phe  Pro Leu Leu Gln Phe  Lys Ser Lys Gln Glu  Phe Gln Pro 
    2225                 2230                 2235             


Leu Phe  Leu His Thr Gly Ser  Ile Pro Gln Val Pro  Phe Arg Pro 
    2240                 2245                 2250             


Leu Pro  Gln Pro Arg Glu Ala  Trp Gly Leu Ser Asp  Ser Phe Gln 
    2255                 2260                 2265             


Pro Ala  Leu Pro Gln Arg Ala  Ala Gln Thr Thr Pro  Ala Ser His 
    2270                 2275                 2280             


Leu Asn  Val Ser Gln Tyr Asn  Thr Glu Ala Arg Lys  Lys Glu Val 
    2285                 2290                 2295             


Glu Gln  Lys Thr Trp Ala Glu  Thr Val Ile Thr Glu  Ile Pro Asn 
    2300                 2305                 2310             


His Val  Asn Leu Asp Gln Tyr  Val Gly Gln Glu Asn  Leu Thr Pro 
    2315                 2320                 2325             


Gln Gln  Asp Ser Ser Val Phe  Ile Lys Pro Glu Lys  Leu Phe Asp 
    2330                 2335                 2340             


Val Lys  Pro Gly Thr Leu Glu  Ile Ser Pro His His  Ser Phe Gly 
    2345                 2350                 2355             


Leu Pro  Leu Leu Tyr Leu Pro  Leu Lys Pro Pro Asn  Met Phe Pro 
    2360                 2365                 2370             


Ser Thr  Ser Arg Ala Ser Ile  Thr Val Pro Ser Thr  Pro Ile Gln 
    2375                 2380                 2385             


Pro Ile  Ala Glu Glu Arg Lys  Tyr Pro Arg Leu Ser  Leu Leu His 
    2390                 2395                 2400             


Ser His  Leu Ser Pro Glu Asn  Arg Cys Lys Lys Thr  Gln Leu Ile 
    2405                 2410                 2415             


Pro Leu  Glu Asn Leu Ile Ala  Phe Lys Gln Ser Gln  Gln Lys Leu 
    2420                 2425                 2430             


Thr His  Asn Leu Phe Glu Gln  Gly Asp Ala Gly His  Leu Gln Leu 
    2435                 2440                 2445             


Leu Lys  Val Lys Ile Glu Pro  Pro Glu Val Arg Gln  Gly Lys Asp 
    2450                 2455                 2460             


Ser Lys  Lys Arg Gln Arg Arg  Arg Ala Glu Lys Glu  Leu Gln Glu 
    2465                 2470                 2475             


Lys Arg  Cys Glu Lys Leu Arg  Arg Lys Pro Asn Val  Thr Phe Arg 
    2480                 2485                 2490             


Pro Glu  Asn Ser Ile Ile Asn  Asn Asp Asp Ser Glu  Ile Ile Lys 
    2495                 2500                 2505             


Lys Pro  Lys Glu Gln Gln Glu  His Cys Gly Ser His  Pro Leu Asp 
    2510                 2515                 2520             


Asp Phe  Asp Val Pro Phe Glu  Met Leu Gln Asp Asp  Asn Thr Ser 
    2525                 2530                 2535             


Ala Gly  Leu His Phe Met Ala  Ser Val Lys Lys Lys  Ala Ile Gly 
    2540                 2545                 2550             


Ser Gln  Asp Ala Ser Thr Asn  Thr Asp Pro Glu His  Glu Pro Leu 
    2555                 2560                 2565             


Thr Ala  Pro Gln Leu Leu Val  Pro Asp Val Tyr Leu  Asn Leu Lys 
    2570                 2575                 2580             


Leu Ser  Ser Glu Met Ser Glu  Lys Pro Trp Ser Pro  Ser Ile Pro 
    2585                 2590                 2595             


His Thr  Val Thr Asn Leu Glu  Leu Pro Val Arg Glu  Glu Pro Ser 
    2600                 2605                 2610             


Asn Asp  Asn Val Ile Lys Gln  Gln Ser Asp His Leu  Ala Val Pro 
    2615                 2620                 2625             


Ser Ser  Ala Glu Leu His Tyr  Met Ala Ala Ser Val  Thr Asn Ala 
    2630                 2635                 2640             


Val Pro  Pro His Asn Phe Lys  Ser Gln Gly Leu Pro  Lys Pro Glu 
    2645                 2650                 2655             


Phe Arg  Phe Lys Gly Gln Ser  Thr Lys Ser Asp Ser  Ala Glu Asp 
    2660                 2665                 2670             


Tyr Leu  Leu Trp Lys Arg Leu  Gln Gly Val Ser Ala  Ala Cys Pro 
    2675                 2680                 2685             


Ala Pro  Ser Ser Ala Ala His  Gln Leu Glu His Leu  Ser Ala Lys 
    2690                 2695                 2700             


Leu Gln  Lys Ile Asp Glu Gln  Leu Leu Ala Ile Gln  Asn Ile Ala 
    2705                 2710                 2715             


Glu Asn  Ile Glu Gln Asp Phe  Pro Lys Pro Glu Met  Leu Asp Leu 
    2720                 2725                 2730             


His Cys  Asp Lys Ile Gly Pro  Val Asp His Ile Glu  Phe Ser Ser 
    2735                 2740                 2745             


Gly Pro  Glu Phe Lys Lys Thr  Leu Ala Ser Lys Thr  Ile Ser Ile 
    2750                 2755                 2760             


Ser Glu  Glu Val Arg Phe Leu  Thr His Met Asp Glu  Glu Asp Gln 
    2765                 2770                 2775             


Ser Asp  Lys Lys Glu Thr Ser  Glu Pro Glu Phe Ser  Ile Thr Glu 
    2780                 2785                 2790             


Asn Tyr  Ser Gly Gln Lys Thr  Cys Val Phe Pro Thr  Ala Asp Ser 
    2795                 2800                 2805             


Ala Val  Ser Leu Ser Ser Ser  Ser Asp Gln Asn Thr  Thr Ser Pro 
    2810                 2815                 2820             


Gly Met  Asn Ser Ser Asp Glu  Leu Cys Glu Ser Val  Ser Val His 
    2825                 2830                 2835             


Pro Leu  Gln Met Thr Gly Leu  Thr Asp Ile Ala Asp  Ile Ile Asp 
    2840                 2845                 2850             


Asp Leu  Ile Ile Lys Asp Gly  Val Ser Ser Glu Glu  Leu Gly Leu 
    2855                 2860                 2865             


Thr Glu  Gln Ala Met Gly Thr  Ser Arg Ile Gln His  Tyr Ser Gly 
    2870                 2875                 2880             


Arg His  Ser Gln Arg Thr Asp  Lys Glu Arg Arg Glu  Ile Gln Ala 
    2885                 2890                 2895             


Trp Met  Lys Arg Lys Arg Lys  Glu Arg Met Ala Lys  Tyr Leu Asn 
    2900                 2905                 2910             


Glu Leu  Ala Glu Lys Arg Gly  Gln Glu His Asp Pro  Phe Cys Pro 
    2915                 2920                 2925             


Arg Ser  Asn Pro Leu Tyr Met  Thr Ser Arg Glu Ile  Arg Leu Arg 
    2930                 2935                 2940             


Gln Lys  Met Lys His Glu Lys  Asp Arg Leu Leu Leu  Ser Glu His 
    2945                 2950                 2955             


Tyr Ser  Arg Arg Ile Ser Gln  Ala Tyr Gly Leu Met  Asn Glu Leu 
    2960                 2965                 2970             


Leu Ser  Glu Ser Val Gln Leu  Pro Thr Leu Pro Gln  Lys Pro Leu 
    2975                 2980                 2985             


Pro Asn  Lys Pro Ser Pro Thr  Gln Ser Ser Ser Cys  Gln His Cys 
    2990                 2995                 3000             


Pro Ser  Pro Arg Gly Glu Asn  Gln His Gly His Ser  Phe Leu Ile 
    3005                 3010                 3015             


Asn Arg  Pro Gly Lys Val Lys  Tyr Met Ser Lys Pro  Ser Tyr Ile 
    3020                 3025                 3030             


His Lys  Arg Lys Ser Phe Gly  Gln Pro Gln Gly Ser  Pro Trp Pro 
    3035                 3040                 3045             


His Gly  Thr Ala Thr Phe Thr  Ile Gln Lys Lys Ala  Gly Gly Ala 
    3050                 3055                 3060             


Lys Ala  Ala Val Arg Lys Ala  Thr Gln Ser Pro Val  Thr Phe Gln 
    3065                 3070                 3075             


Lys Gly  Ser Asn Ala Pro Cys  His Ser Leu Gln His  Thr Lys Lys 
    3080                 3085                 3090             


His Gly  Ser Ala Gly Leu Ala  Pro Gln Thr Lys Gln  Val Cys Val 
    3095                 3100                 3105             


Glu Tyr  Glu Arg Glu Glu Thr  Val Val Ser Pro Trp  Thr Ile Pro 
    3110                 3115                 3120             


Ser Glu  Ile His Lys Ile Leu  His Glu Ser His Asn  Ser Leu Leu 
    3125                 3130                 3135             


Gln Asp  Leu Ser Pro Thr Glu  Glu Glu Glu Pro Glu  His Pro Phe 
    3140                 3145                 3150             


Gly Val  Gly Gly Val Asp Ser  Val Ser Glu Ser Thr  Gly Ser Ile 
    3155                 3160                 3165             


Leu Ser  Lys Leu Asp Trp Asn  Ala Ile Glu Asp Met  Val Ala Ser 
    3170                 3175                 3180             


Val Glu  Asp Gln Gly Leu Ser  Val His Trp Ala Leu  Asp Leu 
    3185                 3190                 3195         


<210>  1436
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5orf63__Homo_sapiens__NP_001157950

<400>  1436

Met Leu Trp Phe Gln Gly Asn Ser Met Gln Leu Ala Arg Ser Ser Phe 
1               5                   10                  15      


Gly Leu Phe Leu Arg Asn Cys Ser Ala Ser Lys Thr Thr Leu Pro Val 
            20                  25                  30          


Leu Thr Leu Phe Thr Lys Asp Pro Cys Pro Leu Cys Asp Glu Ala Lys 
        35                  40                  45              


Glu Val Leu Lys Pro Tyr Glu Asn Arg Phe Ile Leu Gln Glu Val Asn 
    50                  55                  60                  


Ile Thr Leu Pro Glu Asn Ser Val Trp Tyr Glu Arg Tyr Lys Phe Asp 
65                  70                  75                  80  


Ile Pro Val Phe His Leu Asn Gly Gln Phe Leu Met Met His Arg Val 
                85                  90                  95      


Asn Thr Ser Lys Leu Glu Lys Gln Leu Leu Lys Leu Glu Gln Gln Ser 
            100                 105                 110         


Thr Gly Gly 
        115 


<210>  1437
<211>  934
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6__Homo_sapiens__NP_000056

<400>  1437

Met Ala Arg Arg Ser Val Leu Tyr Phe Ile Leu Leu Asn Ala Leu Ile 
1               5                   10                  15      


Asn Lys Gly Gln Ala Cys Phe Cys Asp His Tyr Ala Trp Thr Gln Trp 
            20                  25                  30          


Thr Ser Cys Ser Lys Thr Cys Asn Ser Gly Thr Gln Ser Arg His Arg 
        35                  40                  45              


Gln Ile Val Val Asp Lys Tyr Tyr Gln Glu Asn Phe Cys Glu Gln Ile 
    50                  55                  60                  


Cys Ser Lys Gln Glu Thr Arg Glu Cys Asn Trp Gln Arg Cys Pro Ile 
65                  70                  75                  80  


Asn Cys Leu Leu Gly Asp Phe Gly Pro Trp Ser Asp Cys Asp Pro Cys 
                85                  90                  95      


Ile Glu Lys Gln Ser Lys Val Arg Ser Val Leu Arg Pro Ser Gln Phe 
            100                 105                 110         


Gly Gly Gln Pro Cys Thr Ala Pro Leu Val Ala Phe Gln Pro Cys Ile 
        115                 120                 125             


Pro Ser Lys Leu Cys Lys Ile Glu Glu Ala Asp Cys Lys Asn Lys Phe 
    130                 135                 140                 


Arg Cys Asp Ser Gly Arg Cys Ile Ala Arg Lys Leu Glu Cys Asn Gly 
145                 150                 155                 160 


Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg Asp Cys Gly Arg Thr 
                165                 170                 175     


Lys Ala Val Cys Thr Arg Lys Tyr Asn Pro Ile Pro Ser Val Gln Leu 
            180                 185                 190         


Met Gly Asn Gly Phe His Phe Leu Ala Gly Glu Pro Arg Gly Glu Val 
        195                 200                 205             


Leu Asp Asn Ser Phe Thr Gly Gly Ile Cys Lys Thr Val Lys Ser Ser 
    210                 215                 220                 


Arg Thr Ser Asn Pro Tyr Arg Val Pro Ala Asn Leu Glu Asn Val Gly 
225                 230                 235                 240 


Phe Glu Val Gln Thr Ala Glu Asp Asp Leu Lys Thr Asp Phe Tyr Lys 
                245                 250                 255     


Asp Leu Thr Ser Leu Gly His Asn Glu Asn Gln Gln Gly Ser Phe Ser 
            260                 265                 270         


Ser Gln Gly Gly Ser Ser Phe Ser Val Pro Ile Phe Tyr Ser Ser Lys 
        275                 280                 285             


Arg Ser Glu Asn Ile Asn His Asn Ser Ala Phe Lys Gln Ala Ile Gln 
    290                 295                 300                 


Ala Ser His Lys Lys Asp Ser Ser Phe Ile Arg Ile His Lys Val Met 
305                 310                 315                 320 


Lys Val Leu Asn Phe Thr Thr Lys Ala Lys Asp Leu His Leu Ser Asp 
                325                 330                 335     


Val Phe Leu Lys Ala Leu Asn His Leu Pro Leu Glu Tyr Asn Ser Ala 
            340                 345                 350         


Leu Tyr Ser Arg Ile Phe Asp Asp Phe Gly Thr His Tyr Phe Thr Ser 
        355                 360                 365             


Gly Ser Leu Gly Gly Val Tyr Asp Leu Leu Tyr Gln Phe Ser Ser Glu 
    370                 375                 380                 


Glu Leu Lys Asn Ser Gly Leu Thr Glu Glu Glu Ala Lys His Cys Val 
385                 390                 395                 400 


Arg Ile Glu Thr Lys Lys Arg Val Leu Phe Ala Lys Lys Thr Lys Val 
                405                 410                 415     


Glu His Arg Cys Thr Thr Asn Lys Leu Ser Glu Lys His Glu Gly Ser 
            420                 425                 430         


Phe Ile Gln Gly Ala Glu Lys Ser Ile Ser Leu Ile Arg Gly Gly Arg 
        435                 440                 445             


Ser Glu Tyr Gly Ala Ala Leu Ala Trp Glu Lys Gly Ser Ser Gly Leu 
    450                 455                 460                 


Glu Glu Lys Thr Phe Ser Glu Trp Leu Glu Ser Val Lys Glu Asn Pro 
465                 470                 475                 480 


Ala Val Ile Asp Phe Glu Leu Ala Pro Ile Val Asp Leu Val Arg Asn 
                485                 490                 495     


Ile Pro Cys Ala Val Thr Lys Arg Asn Asn Leu Arg Lys Ala Leu Gln 
            500                 505                 510         


Glu Tyr Ala Ala Lys Phe Asp Pro Cys Gln Cys Ala Pro Cys Pro Asn 
        515                 520                 525             


Asn Gly Arg Pro Thr Leu Ser Gly Thr Glu Cys Leu Cys Val Cys Gln 
    530                 535                 540                 


Ser Gly Thr Tyr Gly Glu Asn Cys Glu Lys Gln Ser Pro Asp Tyr Lys 
545                 550                 555                 560 


Ser Asn Ala Val Asp Gly Gln Trp Gly Cys Trp Ser Ser Trp Ser Thr 
                565                 570                 575     


Cys Asp Ala Thr Tyr Lys Arg Ser Arg Thr Arg Glu Cys Asn Asn Pro 
            580                 585                 590         


Ala Pro Gln Arg Gly Gly Lys Arg Cys Glu Gly Glu Lys Arg Gln Glu 
        595                 600                 605             


Glu Asp Cys Thr Phe Ser Ile Met Glu Asn Asn Gly Gln Pro Cys Ile 
    610                 615                 620                 


Asn Asp Asp Glu Glu Met Lys Glu Val Asp Leu Pro Glu Ile Glu Ala 
625                 630                 635                 640 


Asp Ser Gly Cys Pro Gln Pro Val Pro Pro Glu Asn Gly Phe Ile Arg 
                645                 650                 655     


Asn Glu Lys Gln Leu Tyr Leu Val Gly Glu Asp Val Glu Ile Ser Cys 
            660                 665                 670         


Leu Thr Gly Phe Glu Thr Val Gly Tyr Gln Tyr Phe Arg Cys Leu Pro 
        675                 680                 685             


Asp Gly Thr Trp Arg Gln Gly Asp Val Glu Cys Gln Arg Thr Glu Cys 
    690                 695                 700                 


Ile Lys Pro Val Val Gln Glu Val Leu Thr Ile Thr Pro Phe Gln Arg 
705                 710                 715                 720 


Leu Tyr Arg Ile Gly Glu Ser Ile Glu Leu Thr Cys Pro Lys Gly Phe 
                725                 730                 735     


Val Val Ala Gly Pro Ser Arg Tyr Thr Cys Gln Gly Asn Ser Trp Thr 
            740                 745                 750         


Pro Pro Ile Ser Asn Ser Leu Thr Cys Glu Lys Asp Thr Leu Thr Lys 
        755                 760                 765             


Leu Lys Gly His Cys Gln Leu Gly Gln Lys Gln Ser Gly Ser Glu Cys 
    770                 775                 780                 


Ile Cys Met Ser Pro Glu Glu Asp Cys Ser His His Ser Glu Asp Leu 
785                 790                 795                 800 


Cys Val Phe Asp Thr Asp Ser Asn Asp Tyr Phe Thr Ser Pro Ala Cys 
                805                 810                 815     


Lys Phe Leu Ala Glu Lys Cys Leu Asn Asn Gln Gln Leu His Phe Leu 
            820                 825                 830         


His Ile Gly Ser Cys Gln Asp Gly Arg Gln Leu Glu Trp Gly Leu Glu 
        835                 840                 845             


Arg Thr Arg Leu Ser Ser Asn Ser Thr Lys Lys Glu Ser Cys Gly Tyr 
    850                 855                 860                 


Asp Thr Cys Tyr Asp Trp Glu Lys Cys Ser Ala Ser Thr Ser Lys Cys 
865                 870                 875                 880 


Val Cys Leu Leu Pro Pro Gln Cys Phe Lys Gly Gly Asn Gln Leu Tyr 
                885                 890                 895     


Cys Val Lys Met Gly Ser Ser Thr Ser Glu Lys Thr Leu Asn Ile Cys 
            900                 905                 910         


Glu Val Gly Thr Ile Arg Cys Ala Asn Arg Lys Met Glu Ile Leu His 
        915                 920                 925             


Pro Gly Lys Cys Leu Ala 
    930                 


<210>  1438
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6orf106__Homo_sapiens__NP_073595

<400>  1438

Met Glu Gly Met Asp Val Asp Leu Asp Pro Glu Leu Met Gln Lys Phe 
1               5                   10                  15      


Ser Cys Leu Gly Thr Thr Asp Lys Asp Val Leu Ile Ser Glu Phe Gln 
            20                  25                  30          


Arg Leu Leu Gly Phe Gln Leu Asn Pro Ala Gly Cys Ala Phe Phe Leu 
        35                  40                  45              


Asp Met Thr Asn Trp Asn Leu Gln Ala Ala Ile Gly Ala Tyr Tyr Asp 
    50                  55                  60                  


Phe Glu Ser Pro Asn Ile Ser Val Pro Ser Met Ser Phe Val Glu Asp 
65                  70                  75                  80  


Val Thr Ile Gly Glu Gly Glu Ser Ile Pro Pro Asp Thr Gln Phe Val 
                85                  90                  95      


Lys Thr Trp Arg Ile Gln Asn Ser Asp Val Ile Trp Val Ile Leu Ser 
            100                 105                 110         


Val Glu Val Gly Gly Leu Leu Gly Val Thr Gln Gln Leu Ser Ser Phe 
        115                 120                 125             


Glu Thr Glu Phe Asn Thr Gln Pro His Arg Lys Val Glu Gly Asn Phe 
    130                 135                 140                 


Asn Pro Phe Ala Ser Pro Gln Lys Asn Arg Gln Ser Asp Glu Asn Asn 
145                 150                 155                 160 


Leu Lys Asp Pro Gly Gly Ser Glu Phe Asp Ser Ile Ser Lys Asn Thr 
                165                 170                 175     


Trp Ala Pro Ala Pro Asp Thr Trp Ala Pro Ala Pro Asp Gln Thr Glu 
            180                 185                 190         


Gln Asp Gln Asn Arg Leu Ser Gln Asn Ser Val Asn Leu Ser Pro Ser 
        195                 200                 205             


Ser His Ala Asn Asn Leu Ser Val Val Thr Tyr Ser Lys Gly Leu His 
    210                 215                 220                 


Gly Pro Tyr Pro Phe Gly Gln Ser 
225                 230         


<210>  1439
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6orf10__Homo_sapiens__XP_011512542

<400>  1439

Met Thr Val Leu Glu Ile Thr Leu Ala Val Ile Leu Thr Leu Leu Gly 
1               5                   10                  15      


Leu Ala Ile Leu Ala Ile Leu Leu Thr Arg Trp Ala Arg Cys Lys Gln 
            20                  25                  30          


Ser Glu Met Tyr Ile Ser Arg Tyr Ser Ser Glu Gln Ser Ala Arg Leu 
        35                  40                  45              


Leu Asp Tyr Glu Asp Gly Arg Gly Ser Arg His Ala Tyr Ser Thr Gln 
    50                  55                  60                  


Ser Asp Thr Ser Tyr Asp Asn Arg Glu Arg Ser Lys Arg Asp Tyr Thr 
65                  70                  75                  80  


Pro Ser Thr Asn Ser Leu Val Ser Met Ala Ser Lys Phe Ser Leu Gly 
                85                  90                  95      


Gln Thr Glu Leu Ile Leu Leu Leu Met Cys Phe Ile Leu Ala Leu Ser 
            100                 105                 110         


Arg Ser Ser Ile Gly Ser Ile Lys Cys Leu Gln Thr Thr Glu Glu Pro 
        115                 120                 125             


Pro Ser Arg Thr Ala Gly Ala Met Met Gln Phe Thr Ala Pro Ile Pro 
    130                 135                 140                 


Gly Ala Thr Gly Pro Ile Lys Leu Ser Gln Lys Thr Ile Val Gln Thr 
145                 150                 155                 160 


Pro Gly Pro Ile Val Gln Tyr Pro Gly Ser Asn Ala Gly Pro Pro Ser 
                165                 170                 175     


Ala Pro Arg Gly Pro Pro Met Ala Pro Ile Ile Ile Ser Gln Arg Thr 
            180                 185                 190         


Ala Arg Ile Pro Gln Val His Thr Met Asp Ser Ser Gly Lys Ile Thr 
        195                 200                 205             


Leu Thr Pro Val Val Ile Leu Thr Gly Tyr Met Asp Glu Glu Leu Ala 
    210                 215                 220                 


Lys Lys Ser Cys Ser Lys Ile Gln Ile Leu Lys Cys Gly Gly Thr Ala 
225                 230                 235                 240 


Arg Ser Gln Asn Ser Arg Glu Glu Asn Lys Glu Ala Leu Lys Asn Asp 
                245                 250                 255     


Ile Ile Phe Thr Asn Ser Val Glu Ser Leu Lys Ser Ala His Ile Lys 
            260                 265                 270         


Glu Pro Glu Arg Glu Gly Lys Gly Thr Asp Leu Glu Lys Asp Lys Ile 
        275                 280                 285             


Gly Met Glu Val Lys Val Asp Ser Asp Ala Gly Ile Pro Lys Arg Gln 
    290                 295                 300                 


Glu Thr Gln Leu Lys Ile Ser Glu Met Ser Ile Pro Gln Gly Gln Gly 
305                 310                 315                 320 


Ala Gln Ile Lys Lys Ser Val Ser Asp Val Pro Arg Gly Gln Glu Ser 
                325                 330                 335     


Gln Val Lys Lys Ser Glu Ser Gly Val Pro Lys Gly Gln Glu Ala Gln 
            340                 345                 350         


Val Thr Lys Ser Gly Leu Val Val Leu Lys Gly Gln Glu Ala Gln Val 
        355                 360                 365             


Glu Lys Ser Glu Met Gly Val Pro Arg Arg Gln Glu Ser Gln Val Lys 
    370                 375                 380                 


Lys Ser Gln Ser Gly Val Ser Lys Gly Gln Glu Ala Gln Val Lys Lys 
385                 390                 395                 400 


Arg Glu Ser Val Val Leu Lys Gly Gln Glu Ala Gln Val Glu Lys Ser 
                405                 410                 415     


Glu Leu Lys Val Pro Lys Gly Gln Glu Gly Gln Val Glu Lys Thr Glu 
            420                 425                 430         


Ala Asp Val Pro Lys Glu Gln Glu Val Gln Glu Lys Lys Ser Glu Ala 
        435                 440                 445             


Gly Val Leu Lys Gly Pro Glu Ser Gln Val Lys Asn Thr Glu Val Ser 
    450                 455                 460                 


Val Pro Glu Thr Leu Glu Ser Gln Val Lys Lys Ser Glu Ser Gly Val 
465                 470                 475                 480 


Leu Lys Gly Gln Glu Ala Gln Glu Lys Lys Glu Ser Phe Glu Asp Lys 
                485                 490                 495     


Gly Asn Asn Asp Lys Glu Lys Glu Arg Asp Ala Glu Lys Asp Pro Asn 
            500                 505                 510         


Lys Lys Glu Lys Gly Asp Lys Asn Thr Lys Gly Asp Lys Gly Lys Asp 
        515                 520                 525             


Lys Val Lys Gly Lys Arg Glu Ser Glu Ile Asn Gly Glu Lys Ser Lys 
    530                 535                 540                 


Gly Ser Lys Arg Ala Lys Ala Asn Thr Gly Arg Lys Tyr Asn Lys Lys 
545                 550                 555                 560 


Val Glu Glu 
            


<210>  1440
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6orf15__Homo_sapiens__NP_054789

<400>  1440

Met Gln Gly Arg Val Ala Gly Ser Cys Ala Pro Leu Gly Leu Leu Leu 
1               5                   10                  15      


Val Cys Leu His Leu Pro Gly Leu Phe Ala Arg Ser Ile Gly Val Val 
            20                  25                  30          


Glu Glu Lys Val Ser Gln Asn Leu Gly Thr Asn Leu Pro Gln Leu Gly 
        35                  40                  45              


Gln Pro Ser Ser Thr Gly Pro Ser Asn Ser Glu His Pro Gln Pro Ala 
    50                  55                  60                  


Leu Asp Pro Arg Ser Asn Asp Leu Ala Arg Val Pro Leu Lys Leu Ser 
65                  70                  75                  80  


Val Pro Ala Ser Asp Gly Phe Pro Pro Ala Gly Gly Ser Ala Val Gln 
                85                  90                  95      


Arg Trp Pro Pro Ser Trp Gly Leu Pro Ala Met Asp Ser Trp Pro Pro 
            100                 105                 110         


Glu Asp Pro Trp Gln Met Met Ala Ala Ala Ala Glu Asp Arg Leu Gly 
        115                 120                 125             


Glu Ala Leu Pro Glu Glu Leu Ser Tyr Leu Ser Ser Ala Ala Ala Leu 
    130                 135                 140                 


Ala Pro Gly Ser Gly Pro Leu Pro Gly Glu Ser Ser Pro Asp Ala Thr 
145                 150                 155                 160 


Gly Leu Ser Pro Lys Ala Ser Leu Leu His Gln Asp Ser Glu Ser Arg 
                165                 170                 175     


Arg Leu Pro Arg Ser Asn Ser Leu Gly Ala Gly Gly Lys Ile Leu Ser 
            180                 185                 190         


Gln Arg Pro Pro Trp Ser Leu Ile His Arg Val Leu Pro Asp His Pro 
        195                 200                 205             


Trp Gly Thr Leu Asn Pro Ser Val Ser Trp Gly Gly Gly Gly Pro Gly 
    210                 215                 220                 


Thr Gly Trp Gly Thr Arg Pro Met Pro His Pro Glu Gly Ile Trp Gly 
225                 230                 235                 240 


Ile Asn Asn Gln Pro Pro Gly Thr Ser Trp Gly Asn Ile Asn Arg Tyr 
                245                 250                 255     


Pro Gly Gly Ser Trp Gly Asn Ile Asn Arg Tyr Pro Gly Gly Ser Trp 
            260                 265                 270         


Gly Asn Ile Asn Arg Tyr Pro Gly Gly Ser Trp Gly Asn Ile His Leu 
        275                 280                 285             


Tyr Pro Gly Ile Asn Asn Pro Phe Pro Pro Gly Val Leu Arg Pro Pro 
    290                 295                 300                 


Gly Ser Ser Trp Asn Ile Pro Ala Gly Phe Pro Asn Pro Pro Ser Pro 
305                 310                 315                 320 


Arg Leu Gln Trp Gly 
                325 


<210>  1441
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6orf25__Homo_sapiens__NP_079536

<400>  1441

Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln 
1               5                   10                  15      


Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn 
            20                  25                  30          


Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro 
        35                  40                  45              


Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu 
    50                  55                  60                  


Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe 
65                  70                  75                  80  


Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu 
                85                  90                  95      


Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His 
            100                 105                 110         


Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr 
        115                 120                 125             


Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu 
    130                 135                 140                 


Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly 
145                 150                 155                 160 


Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro 
                165                 170                 175     


Leu Pro Arg Phe Ala Leu Ser Pro Pro His Ser Ser Thr Cys Glu Asn 
            180                 185                 190         


Arg Ala Pro Glu Ala Ser Lys Gly Gly Arg Ala Gln Asp Ser Arg Gly 
        195                 200                 205             


Pro Gly Pro Gly Thr Glu Pro Ala Leu Cys Gly Ser Gly Pro Ser Ser 
    210                 215                 220                 


Pro Gln Gln Ala Pro Pro Ala Val His Ser Gly Pro Cys 
225                 230                 235         


<210>  1442
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6orf47__Homo_sapiens__NP_067007

<400>  1442

Met Phe Leu Arg Arg Leu Gly Gly Trp Leu Pro Arg Pro Trp Gly Arg 
1               5                   10                  15      


Arg Lys Pro Met Arg Pro Asp Pro Pro Tyr Pro Glu Pro Arg Arg Val 
            20                  25                  30          


Asp Ser Ser Ser Glu Asn Ser Gly Ser Asp Trp Asp Ser Ala Pro Glu 
        35                  40                  45              


Thr Met Glu Asp Val Gly His Pro Lys Thr Lys Asp Ser Gly Ala Leu 
    50                  55                  60                  


Arg Val Ser Gly Ala Ala Ser Glu Pro Ser Lys Glu Glu Pro Gln Val 
65                  70                  75                  80  


Glu Gln Leu Gly Ser Lys Arg Met Asp Ser Leu Lys Trp Asp Gln Pro 
                85                  90                  95      


Ile Ser Ser Thr Gln Glu Ser Gly Arg Leu Glu Ala Gly Gly Ala Ser 
            100                 105                 110         


Pro Lys Leu Arg Trp Asp His Val Asp Ser Gly Gly Thr Arg Arg Pro 
        115                 120                 125             


Gly Val Ser Pro Glu Gly Gly Leu Ser Val Pro Gly Pro Gly Ala Pro 
    130                 135                 140                 


Leu Glu Lys Pro Gly Arg Arg Glu Lys Leu Leu Gly Trp Leu Arg Gly 
145                 150                 155                 160 


Glu Pro Gly Ala Pro Ser Arg Tyr Leu Gly Gly Pro Glu Glu Cys Leu 
                165                 170                 175     


Gln Ile Ser Thr Asn Leu Thr Leu His Leu Leu Glu Leu Leu Ala Ser 
            180                 185                 190         


Ala Leu Leu Ala Leu Cys Ser Arg Pro Leu Arg Ala Ala Leu Asp Thr 
        195                 200                 205             


Leu Gly Leu Arg Gly Pro Leu Gly Leu Trp Leu His Gly Leu Leu Ser 
    210                 215                 220                 


Phe Leu Ala Ala Leu His Gly Leu His Ala Val Leu Ser Leu Leu Thr 
225                 230                 235                 240 


Ala His Pro Leu His Phe Ala Cys Leu Phe Gly Leu Leu Gln Ala Leu 
                245                 250                 255     


Val Leu Ala Val Ser Leu Arg Glu Pro Asn Gly Asp Glu Ala Ala Thr 
            260                 265                 270         


Asp Trp Glu Ser Glu Gly Leu Glu Arg Glu Gly Glu Glu Gln Arg Gly 
        275                 280                 285             


Asp Pro Gly Lys Gly Leu 
    290                 


<210>  1443
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6orf48__Homo_sapiens__NP_001274413

<400>  1443

Met Glu Arg Ser Phe Val Trp Leu Ser Cys Leu Asp Ser Asp Ser Cys 
1               5                   10                  15      


Asn Leu Thr Phe Arg Leu Gly Glu Val Glu Ser His Ala Cys Ser Pro 
            20                  25                  30          


Ser Leu Leu Trp Asn Leu Leu Thr Gln Tyr Leu Pro Pro Gly Ala Gly 
        35                  40                  45              


His Ile Leu Arg Thr Tyr Asn Phe Pro Val Leu Ser Cys Val Ser Ser 
    50                  55                  60                  


Cys His Leu Ile Gly Gly Lys Met Pro Glu Asn 
65                  70                  75  


<210>  1444
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6orf89__Homo_sapiens__NP_001273564

<400>  1444

Met Asp Leu Ala Ala Asn Glu Ile Ser Ile Tyr Asp Lys Leu Ser Glu 
1               5                   10                  15      


Thr Val Asp Leu Val Arg Gln Thr Gly His Gln Cys Gly Met Ser Glu 
            20                  25                  30          


Lys Ala Ile Glu Lys Phe Ile Arg Gln Leu Leu Glu Lys Asn Glu Pro 
        35                  40                  45              


Gln Arg Pro Pro Pro Gln Tyr Pro Leu Leu Ile Val Val Tyr Lys Val 
    50                  55                  60                  


Leu Ala Thr Leu Gly Leu Ile Leu Leu Thr Ala Tyr Phe Val Ile Gln 
65                  70                  75                  80  


Pro Phe Ser Pro Leu Ala Pro Glu Pro Val Leu Ser Gly Ala His Thr 
                85                  90                  95      


Trp Arg Ser Leu Ile His His Ile Arg Leu Met Ser Leu Pro Ile Ala 
            100                 105                 110         


Lys Lys Tyr Met Ser Glu Asn Lys Gly Val Pro Leu His Gly Gly Asp 
        115                 120                 125             


Glu Asp Arg Pro Phe Pro Asp Phe Asp Pro Trp Trp Thr Asn Asp Cys 
    130                 135                 140                 


Glu Gln Asn Glu Ser Glu Pro Ile Pro Ala Asn Cys Thr Gly Cys Ala 
145                 150                 155                 160 


Gln Lys His Leu Lys Val Met Leu Leu Glu Asp Ala Pro Arg Lys Phe 
                165                 170                 175     


Glu Arg Leu His Pro Leu Val Ile Lys Thr Gly Lys Pro Leu Leu Glu 
            180                 185                 190         


Glu Glu Ile Gln His Phe Leu Cys Gln Tyr Pro Glu Ala Thr Glu Gly 
        195                 200                 205             


Phe Ser Glu Gly Phe Phe Ala Lys Trp Trp Arg Cys Phe Pro Glu Arg 
    210                 215                 220                 


Trp Phe Pro Phe Pro Tyr Pro Trp Arg Arg Pro Leu Asn Arg Ser Gln 
225                 230                 235                 240 


Met Leu Arg Glu Leu Phe Pro Val Phe Thr His Leu Pro Phe Pro Lys 
                245                 250                 255     


Asp Ala Ser Leu Asn Lys Cys Ser Phe Leu His Pro Glu Pro Val Val 
            260                 265                 270         


Gly Ser Lys Met His Lys Met Pro Asp Leu Phe Ile Ile Gly Ser Gly 
        275                 280                 285             


Glu Ala Met Leu Gln Leu Ile Pro Pro Phe Gln Cys Arg Arg His Cys 
    290                 295                 300                 


Gln Ser Val Ala Met Pro Ile Glu Pro Gly Asp Ile Gly Tyr Val Asp 
305                 310                 315                 320 


Thr Thr His Trp Lys Val Tyr Val Ile Ala Arg Gly Val Gln Pro Leu 
                325                 330                 335     


Val Ile Cys Asp Gly Thr Ala Phe Ser Glu Leu 
            340                 345         


<210>  1445
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7__Homo_sapiens__NP_000578

<400>  1445

Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 
1               5                   10                  15      


Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 
            20                  25                  30          


Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 
        35                  40                  45              


Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 
    50                  55                  60                  


Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro 
65                  70                  75                  80  


Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 
                85                  90                  95      


Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 
            100                 105                 110         


Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 
        115                 120                 125             


Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 
    130                 135                 140                 


Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser 
145                 150                 155                 160 


Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 
                165                 170                 175     


Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 
            180                 185                 190         


Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 
        195                 200                 205             


Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 
    210                 215                 220                 


Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn 
225                 230                 235                 240 


Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 
                245                 250                 255     


Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 
            260                 265                 270         


Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 
        275                 280                 285             


Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 
    290                 295                 300                 


Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp 
305                 310                 315                 320 


Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 
                325                 330                 335     


Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 
            340                 345                 350         


Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 
        355                 360                 365             


Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 
    370                 375                 380                 


Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys 
385                 390                 395                 400 


Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 
                405                 410                 415     


Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 
            420                 425                 430         


Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 
        435                 440                 445             


Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 
    450                 455                 460                 


Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr 
465                 470                 475                 480 


Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 
                485                 490                 495     


Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 
            500                 505                 510         


Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 
        515                 520                 525             


Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 
    530                 535                 540                 


Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys 
545                 550                 555                 560 


Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 
                565                 570                 575     


Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly 
            580                 585                 590         


Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 
        595                 600                 605             


Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 
    610                 615                 620                 


His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile 
625                 630                 635                 640 


Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 
                645                 650                 655     


Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 
            660                 665                 670         


Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 
        675                 680                 685             


Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 
    690                 695                 700                 


Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu 
705                 710                 715                 720 


Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 
                725                 730                 735     


Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 
            740                 745                 750         


Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 
        755                 760                 765             


Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 
    770                 775                 780                 


Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu 
785                 790                 795                 800 


Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 
                805                 810                 815     


Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 
            820                 825                 830         


Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 
        835                 840             


<210>  1446
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7orf49__Homo_sapiens__NP_001230683

<400>  1446

Met Asn Glu Ala Glu Ile Val Asp Val Ala Leu Gly Ile Leu Ile Glu 
1               5                   10                  15      


Ser Arg Lys Gln Glu Lys Ala Cys Glu Gln Pro Ala Leu Ala Gly Ala 
            20                  25                  30          


Asp Asn Pro Glu His Ser Pro Pro Cys Ser Val Ser Pro His Thr Ser 
        35                  40                  45              


Ser Gly Ser Ser Ser Glu Glu Glu Asp Ser Gly Lys Gln Ala Leu Ala 
    50                  55                  60                  


Pro Gly Leu Ser Pro Ser Gln Arg Pro Gly Gly Ser Ser Ser Ala Cys 
65                  70                  75                  80  


Ser Arg Ser Pro Glu Glu Glu Glu Glu Glu Asp Val Leu Lys Tyr Val 
                85                  90                  95      


Arg Glu Ile Phe Phe Ser 
            100         


<210>  1447
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7orf57__Homo_sapiens__NP_001254795

<400>  1447

Met Pro Asp Tyr Met Val His Glu Glu Phe Asn Pro Asp Gln Ala Asn 
1               5                   10                  15      


Gly Ser Tyr Ala Ser Arg Arg Gly Pro Phe Asp Phe Asp Met Lys Thr 
            20                  25                  30          


Val Trp Gln Arg Glu Ala Glu Glu Leu Glu Lys Glu Lys Lys Lys Leu 
        35                  40                  45              


Arg Leu Pro Ala Ile Asp Ser Lys Tyr Leu Ser Lys Ala Gly Thr Pro 
    50                  55                  60                  


Leu Gly Pro Lys Asn Pro Ala Gly Ser Arg Leu Ser Phe Pro Pro Val 
65                  70                  75                  80  


Asn Gly Tyr Lys Asp Glu Trp Leu Gln Gln Gln Gln Arg Ala Asp Ser 
                85                  90                  95      


Asp Lys Arg Thr Pro Lys Thr Ser Arg Ala Ser Val Leu Ser Gln Ser 
            100                 105                 110         


Pro Arg Asp Leu Glu Gly Pro Gln Asp Ala Ala Arg Leu Gln Asp Ala 
        115                 120                 125             


Glu Ala Ser Glu Gly Pro Glu Asp Thr Pro Gly Pro Glu Glu Ser Val 
    130                 135                 140                 


Ser Ala Ser Thr Pro Ala Glu Leu Lys 
145                 150             


<210>  1448
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7orf60__Homo_sapiens__NP_689769

<400>  1448

Met Glu Pro Gly Ala Gly Gly Arg Asn Thr Ala Arg Ala Gln Arg Ala 
1               5                   10                  15      


Gly Ser Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu 
            20                  25                  30          


Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg 
        35                  40                  45              


Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His 
    50                  55                  60                  


Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn 
65                  70                  75                  80  


Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile 
                85                  90                  95      


Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys 
            100                 105                 110         


Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys 
        115                 120                 125             


Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Gln Leu Glu Gly His 
    130                 135                 140                 


Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Thr Glu Leu Leu 
145                 150                 155                 160 


Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn 
                165                 170                 175     


Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val 
            180                 185                 190         


Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu 
        195                 200                 205             


Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys 
    210                 215                 220                 


Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val 
225                 230                 235                 240 


Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg 
                245                 250                 255     


Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu 
            260                 265                 270         


Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met 
        275                 280                 285             


Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg 
    290                 295                 300                 


Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys 
305                 310                 315                 320 


Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly 
                325                 330                 335     


Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu Tyr 
            340                 345                 350         


Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln Leu 
        355                 360                 365             


Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp Ser 
    370                 375                 380                 


Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro 
385                 390                 395                 400 


Ile Leu Leu Leu Ser 
                405 


<210>  1449
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7orf62__Homo_sapiens__XP_011514206

<400>  1449

Met Ser Phe Ser Val His Asn Gln Lys Gly Ser Lys Arg Pro Leu Pro 
1               5                   10                  15      


Leu Glu Pro Leu Leu Phe Leu Gln Val Pro Arg Ser Asn Tyr Leu His 
            20                  25                  30          


Phe Gln Glu Glu Lys Gln Arg Leu His Leu Lys Lys Phe Leu Leu Asp 
        35                  40                  45              


Arg Met Phe Leu Val Ala Lys Ile Gln Ala Asn Val Glu Arg Lys Asp 
    50                  55                  60                  


Val Ala Asp Tyr Tyr Glu Gln Met Phe Gln Ser Val Leu Lys His His 
65                  70                  75                  80  


Leu Gly Glu Ala Val Thr Gly Leu Leu Leu Ile Tyr Pro Thr Ser Ile 
                85                  90                  95      


Leu His Ile Leu Glu Ser Ser Ser Asp Thr Leu Tyr Lys Val Leu Leu 
            100                 105                 110         


Asp Tyr Ile Gly His Val Lys Asp Glu Thr Val Phe Phe Ile Gln Gln 
        115                 120                 125             


Met Lys Ile Ile Val Ile Ser His Asn Ile Pro Met Arg Leu Phe Met 
    130                 135                 140                 


Gln Trp His Val Ser Val Ile Lys Val Pro Val Met Tyr Leu Asp Asp 
145                 150                 155                 160 


Val Thr Gln Ser Gln Ser Leu Lys Glu Val Ile Thr Asp Phe Leu Thr 
                165                 170                 175     


Gln Thr His Lys Leu Ser Leu Tyr Leu Cys Gln Thr Met Lys Val Gly 
            180                 185                 190         


Thr Lys Gly Pro Gly Asp Asn Leu His Gln Val Ala Pro Asp Leu Leu 
        195                 200                 205             


Leu Pro Glu Gln Ile Ile Lys Tyr Leu Cys Lys Ser Glu Glu Phe Met 
    210                 215                 220                 


Asp Pro Ala Thr Phe Ile Asn Met Tyr Asn Arg Pro Ile His Ile Thr 
225                 230                 235                 240 


Leu Asp Ser Glu Val Val Trp Pro Ala Pro Ser Arg Phe 
                245                 250             


<210>  1450
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7orf65__Homo_sapiens__NP_001116537

<400>  1450

Met Arg Met Ala Pro Thr Glu Ser Thr Glu Gly Arg Arg Leu Trp Pro 
1               5                   10                  15      


Gly Pro Arg Glu Gly Gly Ser Gly Lys Glu Thr Thr Ser Glu Lys Leu 
            20                  25                  30          


Ser Asn Leu Pro Arg Pro His Ser Tyr Ser Pro Lys Arg Ala Asp Ala 
        35                  40                  45              


Glu Ser Phe Arg Gly Val Pro Ala Ala Phe Lys Lys Cys Arg Glu Val 
    50                  55                  60                  


Phe Arg Ala Cys Trp Gly Ser Arg Glu Leu Leu Phe Leu Phe Lys Ala 
65                  70                  75                  80  


Ile Ser Glu Ala Gly Pro Ala Gln Asn Ser Cys Gly Ile Thr Leu Glu 
                85                  90                  95      


Lys Ala Gly Gly Leu Glu Asp Thr Gly Ser His Trp Leu Ser Trp Ala 
            100                 105                 110         


Arg Cys Lys Val Leu Tyr Ile Asn Gly Phe Thr Asp Pro Trp Lys Asp 
        115                 120                 125             


Ala Gln Ala Trp Ile Leu Ile Val Ser Cys Lys Lys Gly Lys Gly Thr 
    130                 135                 140                 


Pro Glu Arg Glu Gly Arg Asn 
145                 150     


<210>  1451
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7orf69__Homo_sapiens__NP_079307

<400>  1451

Met Gly Phe His Phe Cys Ile Trp Ile Ile Phe Leu Leu Pro Pro Pro 
1               5                   10                  15      


Cys Lys Lys Cys Leu Ser Pro Pro Thr Met Asn Leu Arg Pro Pro Lys 
            20                  25                  30          


Ser Cys Gly Asn Val Phe Tyr Trp Val Leu Val Leu Asn Ser Gly Leu 
        35                  40                  45              


Leu Tyr Lys Phe Cys Gln Thr Ile Lys Cys Arg Ala Asn Trp Arg Pro 
    50                  55                  60                  


Ala Arg Ala Pro Arg Gly Trp Asn Glu Ala Thr Glu Arg His Gln Glu 
65                  70                  75                  80  


Arg Arg Thr Gln Met Glu Thr Glu Met Gly Gly Ile Ser Thr Thr Tyr 
                85                  90                  95      


Trp His Arg Leu Cys Thr Cys Thr Asp Arg Arg Ala Glu Lys Leu Val 
            100                 105                 110         


Met Asp Gly Asn Asn Cys Trp Phe His Lys 
        115                 120         


<210>  1452
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7orf72__Homo_sapiens__NP_001155306

<400>  1452

Met Asp Val Glu Ile Gln Asp Thr Pro Gly Lys Ile Ser Ile Ser Lys 
1               5                   10                  15      


Arg Ser Ile Leu Ser Gly Thr Val Glu Asn Ile Asp Tyr Pro His Tyr 
            20                  25                  30          


Cys Asp Leu Leu Arg Lys Met Asn Met Pro Phe Val Lys Gly Leu Glu 
        35                  40                  45              


Asn Arg His Asn Tyr Gly Arg Phe Glu Lys Lys Cys Asn Pro Ala Phe 
    50                  55                  60                  


Leu Lys Phe His Pro Tyr Pro Pro Ser Val Leu Pro Asp Tyr His Leu 
65                  70                  75                  80  


His Asp Pro Tyr Pro Pro Pro Tyr Gly Pro His Tyr Pro Leu Phe Pro 
                85                  90                  95      


Leu Arg Asp Asp Val Thr Leu Gly Asp Ser Cys Ser Gly Phe Met Ser 
            100                 105                 110         


Pro Gly Gly Asp Ala Asp Leu Asn Pro Gly Ile Gly Arg Thr Ile Pro 
        115                 120                 125             


Thr Leu Val Asp Phe Ser Asp Val Lys Pro Gln His Arg Val Pro Arg 
    130                 135                 140                 


Pro Asp Thr Gly Phe Gln Thr Thr Ile Lys Arg Gln Lys Ile Leu Ser 
145                 150                 155                 160 


Glu Glu Leu Gln Gln Asn Arg Arg Trp Asn Ser Arg Glu Val Pro Asp 
                165                 170                 175     


Ile Ser Ile Arg Ala Arg Leu Gly Gly Trp Thr Ser Pro Leu Lys Val 
            180                 185                 190         


Thr Pro Leu Gln Pro His His Glu Gly Arg Ser Leu Ser His Ile Phe 
        195                 200                 205             


Thr Phe Asp Glu Glu Ala Thr Cys Thr Asp Glu Gly Glu Pro Leu Val 
    210                 215                 220                 


Gln Thr Asn Lys Lys Cys Asn Ala Lys Asp Ser Phe Tyr Lys Ser Ser 
225                 230                 235                 240 


Thr Gln Lys Ala Tyr Glu Asp Val Pro Trp Asp Lys Met Leu Pro Pro 
                245                 250                 255     


Lys Leu Val Pro Glu Glu Thr Thr Leu Glu Lys Ala Ala Asp Pro Ile 
            260                 265                 270         


Ser Gln Cys Phe Thr Leu Lys Arg Tyr Lys Gly Val Pro Ala Ile Thr 
        275                 280                 285             


Gln Met Val Gly Glu Leu Trp Asp Arg Phe Gln Thr Arg Ser Phe Leu 
    290                 295                 300                 


Ala Pro Val Lys Pro Ile Asn Phe Val Ser Ser Ser Ser Arg Ser Lys 
305                 310                 315                 320 


Tyr Ile Pro Leu Tyr Thr Gly His Val Gln Ser Thr Asn Ala Asp Asp 
                325                 330                 335     


Val Asp Asn Pro Leu Gly Asp Ile Ala Ser Leu Ala Lys Gln Arg Tyr 
            340                 345                 350         


Ser Lys Pro Leu Tyr Thr Asn Thr Ser Arg Ala Ala Asn Ile Pro Gly 
        355                 360                 365             


Tyr Thr Gly Lys Val His Phe Thr Ala Thr His Pro Ala Asn Ser Asn 
    370                 375                 380                 


Ile Pro Ser Thr Thr Pro Ser Pro Asp Ser Glu Leu His Arg Val Phe 
385                 390                 395                 400 


Gln Lys Glu Met Ala Val Asp Leu Phe Arg His Gln Ala Pro Leu Ser 
                405                 410                 415     


Arg Leu Val Thr Thr Val Arg Pro Tyr Asn Pro Phe Asn Lys Lys Asp 
            420                 425                 430         


Lys Glu Thr Ile Asp Tyr 
        435             


<210>  1453
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8orf34__Homo_sapiens__NP_001182568

<400>  1453

Met Ser Ser Pro Leu Ala Ser Glu Leu Ser Glu Leu Ala Ala Leu Arg 
1               5                   10                  15      


Pro Gly Phe Arg Leu Ser Ala Pro His Ala Arg Val Ala Pro Arg Ala 
            20                  25                  30          


Ala Thr His Ala Arg Gly Arg Gly Arg Ala Ser His Ala Gly Gln Pro 
        35                  40                  45              


Arg Leu Arg Ser Ser Cys Pro Gly Pro Ser Pro Gly Lys Arg Arg Val 
    50                  55                  60                  


Val Pro Ser Gly Gly Ala Gln Pro Arg Val Leu Pro Ala Leu Ser Ser 
65                  70                  75                  80  


Arg Ser His Leu Phe Pro Met Ala Ser His Pro Gln Thr Arg Ile Gln 
                85                  90                  95      


Ala Tyr Leu Glu Lys Asn Lys Ile Gly Pro Leu Phe Glu Glu Leu Met 
            100                 105                 110         


Thr Lys Leu Ile Thr Glu Thr Pro Asp Gln Pro Ile Pro Phe Leu Ile 
        115                 120                 125             


Asp His Leu Gln Ser Lys Gln Gly Asn Arg Gly Gln Leu Gln Arg Thr 
    130                 135                 140                 


Leu Ser Gly Ser Ala Ala Leu Trp Ala Glu Ser Glu Lys Ser Glu Ser 
145                 150                 155                 160 


Lys Gly Thr Arg Arg Asp Phe Arg Ser Tyr Asp Lys Pro Trp Gln Leu 
                165                 170                 175     


Asn Ala Lys Lys Pro Lys Lys Ser Lys Ser Asp Leu Ala Val Ser Asn 
            180                 185                 190         


Ile Ser Pro Pro Ser Pro Asp Ser Lys Ser Leu Pro Arg Ser Val Glu 
        195                 200                 205             


His Pro Lys Trp Asn Trp Arg Thr Lys Pro Gln Ser Arg Asp Phe Asp 
    210                 215                 220                 


Glu Leu Asn His Ile Leu Gln Glu Ser Lys Lys Leu Gly Lys Ala Leu 
225                 230                 235                 240 


Glu Asn Leu Ser Arg Ser Ile Ala Ile Ser Asp Glu Leu Asp Lys Glu 
                245                 250                 255     


Thr Val Thr Phe Asn Ser Ser Leu Leu Arg Pro Arg Val Ile Gly Glu 
            260                 265                 270         


Trp Ile Gly Arg Glu Glu Asn Asp Ala Asp Pro Leu Ala Ala Glu Met 
        275                 280                 285             


Leu Gln Pro Pro Ile Pro Arg Ser Lys Asn Asp Gln Trp Glu Ser Glu 
    290                 295                 300                 


Asp Ser Gly Ser Ser Pro Ala Gly Ser Leu Lys Met Glu Pro Lys Asn 
305                 310                 315                 320 


Lys Gly Leu Lys Gln Gln Gln Gln Gln His Lys Lys Leu Leu Ala Ala 
                325                 330                 335     


Met Leu Ser Gln Asp Ser Phe Glu Ser Ile His Ser Pro Thr Pro Ser 
            340                 345                 350         


Val Thr Glu Glu Asp Ile Asp Asn Glu Asp Asp Ala Met Glu Leu Leu 
        355                 360                 365             


Gly Asn Phe Lys Asn 
    370             


<210>  1454
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8orf37__Homo_sapiens__NP_808880

<400>  1454

Met Ala Glu Asp Leu Asp Glu Leu Leu Asp Glu Val Glu Ser Lys Phe 
1               5                   10                  15      


Cys Thr Pro Asp Leu Leu Arg Arg Gly Met Val Glu Gln Pro Lys Gly 
            20                  25                  30          


Cys Gly Gly Gly Thr His Ser Ser Asp Arg Asn Gln Ala Lys Ala Lys 
        35                  40                  45              


Glu Thr Leu Arg Ser Thr Glu Thr Phe Lys Lys Glu Asp Asp Leu Asp 
    50                  55                  60                  


Ser Leu Ile Asn Glu Ile Leu Glu Glu Pro Asn Leu Asp Lys Lys Pro 
65                  70                  75                  80  


Ser Lys Leu Lys Ser Lys Ser Ser Gly Asn Thr Ser Val Arg Ala Ser 
                85                  90                  95      


Ile Glu Gly Leu Gly Lys Ser Cys Ser Pro Val Tyr Leu Gly Gly Ser 
            100                 105                 110         


Ser Ile Pro Cys Gly Ile Gly Thr Asn Ile Ser Trp Arg Ala Cys Asp 
        115                 120                 125             


His Leu Arg Cys Ile Ala Cys Asp Phe Leu Val Val Ser Tyr Asp Asp 
    130                 135                 140                 


Tyr Met Trp Asp Lys Ser Cys Asp Tyr Leu Phe Phe Arg Asn Asn Met 
145                 150                 155                 160 


Pro Glu Phe His Lys Leu Lys Ala Lys Leu Ile Lys Lys Lys Gly Thr 
                165                 170                 175     


Arg Ala Tyr Ala Cys Gln Cys Ser Trp Arg Thr Ile Glu Glu Val Thr 
            180                 185                 190         


Asp Leu Gln Thr Asp His Gln Leu Arg Trp Val Cys Gly Lys His 
        195                 200                 205         


<210>  1455
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8orf46__Homo_sapiens__NP_689978

<400>  1455

Met Met His Gln Ile Tyr Ser Cys Ser Asp Glu Asn Ile Glu Val Phe 
1               5                   10                  15      


Thr Thr Val Ile Pro Ser Lys Val Ser Ser Pro Ala Arg Arg Arg Ala 
            20                  25                  30          


Lys Ser Ser Gln His Leu Leu Thr Lys Asn Val Val Ile Glu Ser Asp 
        35                  40                  45              


Leu Tyr Thr His Gln Pro Leu Glu Leu Leu Pro His Arg Gly Asp Arg 
    50                  55                  60                  


Arg Asp Pro Gly Asp Arg Arg Arg Phe Gly Arg Leu Gln Thr Ala Arg 
65                  70                  75                  80  


Pro Pro Thr Ala His Pro Ala Lys Ala Ser Ala Arg Pro Val Gly Ile 
                85                  90                  95      


Ser Glu Pro Lys Thr Ser Asn Leu Cys Gly Asn Arg Ala Tyr Gly Lys 
            100                 105                 110         


Ser Leu Ile Pro Pro Val Pro Arg Ile Ser Val Lys Thr Ser Ala Ser 
        115                 120                 125             


Ala Ser Leu Glu Ala Thr Ala Met Gly Thr Glu Lys Gly Ala Val Leu 
    130                 135                 140                 


Met Arg Gly Ser Arg His Leu Lys Lys Met Thr Glu Glu Tyr Pro Ala 
145                 150                 155                 160 


Leu Pro Gln Gly Ala Glu Ala Ser Leu Pro Leu Thr Gly Ser Ala Ser 
                165                 170                 175     


Cys Gly Val Pro Gly Ile Leu Arg Lys Met Trp Thr Arg His Lys Lys 
            180                 185                 190         


Lys Ser Glu Tyr Val Gly Ala Thr Asn Ser Ala Phe Glu Ala Asp 
        195                 200                 205         


<210>  1456
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8orf48__Homo_sapiens__NP_001007091

<400>  1456

Met Ala Ile Cys Pro Glu Leu Ala Gln Thr Asp Lys Ser Ala Leu Ala 
1               5                   10                  15      


Asn Leu Ser Asp Glu Thr Glu Thr Leu Lys Asn Phe Thr Asp Glu Val 
            20                  25                  30          


Gln Thr Ser Ser Ser Phe Ser Ser Ser Gly Gly Arg Gln Ser Ser Pro 
        35                  40                  45              


Leu Thr Ser Gly Ser Lys Leu Glu Arg Glu Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Glu Gln Gly Asp Thr Gln Ser Glu Leu Leu Asp Tyr Lys Asn Tyr Glu 
65                  70                  75                  80  


Lys Lys Leu Ser Lys Lys Trp Ile Asn Tyr Leu Lys Leu Lys Asp Ser 
                85                  90                  95      


Asn Phe Glu Arg His Gln Pro Asp Thr Lys Leu Pro Thr Glu Ile Thr 
            100                 105                 110         


Arg Val Ser Asp Glu Glu Leu Asn Ala Leu Gln Ser Tyr Cys Thr Met 
        115                 120                 125             


Lys Ile Asn Leu Ile His Arg Arg Gly Asp Ser Lys Lys Lys Thr Ser 
    130                 135                 140                 


Ser Arg His Lys Lys Leu His Leu Gly Leu Asp Val Glu Ala Ser Glu 
145                 150                 155                 160 


Arg Asp Ala Phe Ser Cys Thr Val Pro Asp Glu Leu Leu Asn Arg Ile 
                165                 170                 175     


Tyr Phe Lys Asn Met Arg Thr Thr Pro Lys Gln Glu Ala Ala Ala Lys 
            180                 185                 190         


Gln His Ile Ser Tyr Gln Cys Pro Tyr Cys Asn Arg Lys Arg Ala Glu 
        195                 200                 205             


Leu Ala Leu Ser Ala Phe Leu Lys Gln Lys Lys Thr Leu Leu Glu Ser 
    210                 215                 220                 


Phe Leu Leu Gln Glu Arg Ile Asp Glu His Leu His Thr Lys Asp Phe 
225                 230                 235                 240 


Leu Thr Arg Ile Gly Glu Ala His Gln Asp Phe Pro Arg Leu Ser Asp 
                245                 250                 255     


Asp Pro Arg Ile Ile Trp Lys Arg Leu Thr Glu Lys Ser His Ile Arg 
            260                 265                 270         


Tyr Ser Gly Phe Glu Arg Ser Glu Thr Glu Gln Lys Met Gln Arg Asp 
        275                 280                 285             


Gly Asn Ser Ala Cys His Leu Pro Phe Ser Leu Pro Phe Leu Lys Arg 
    290                 295                 300                 


Leu Thr Leu Ile Lys Pro Glu Leu Val Ile Val Asn Asp Asn Val 
305                 310                 315                 


<210>  1457
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8orf4__Homo_sapiens__NP_064515

<400>  1457

Met Lys Ala Lys Arg Ser His Gln Ala Ile Ile Met Ser Thr Ser Leu 
1               5                   10                  15      


Arg Val Ser Pro Ser Ile His Gly Tyr His Phe Asp Thr Ala Ser Arg 
            20                  25                  30          


Lys Lys Ala Val Gly Asn Ile Phe Glu Asn Thr Asp Gln Glu Ser Leu 
        35                  40                  45              


Glu Arg Leu Phe Arg Asn Ser Gly Asp Lys Lys Ala Glu Glu Arg Ala 
    50                  55                  60                  


Lys Ile Ile Phe Ala Ile Asp Gln Asp Val Glu Glu Lys Thr Arg Ala 
65                  70                  75                  80  


Leu Met Ala Leu Lys Lys Arg Thr Lys Asp Lys Leu Phe Gln Phe Leu 
                85                  90                  95      


Lys Leu Arg Lys Tyr Ser Ile Lys Val His 
            100                 105     


<210>  1458
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8orf86__Homo_sapiens__NP_997295

<400>  1458

Met Arg Pro Leu Gly Lys Gly Leu Leu Pro Ala Glu Glu Leu Ile Arg 
1               5                   10                  15      


Ser Asn Leu Gly Val Gly Arg Ser Leu Arg Asp Cys Leu Ser Gln Ser 
            20                  25                  30          


Gly Lys Leu Ala Glu Glu Leu Gly Ser Lys Arg Leu Lys Pro Ala Lys 
        35                  40                  45              


Phe Gly Thr Glu Gly Lys Glu Arg Val Glu Gln Arg Thr Glu Arg Gln 
    50                  55                  60                  


Arg Thr Gly Ser Ser Lys Glu Pro Arg Met Gln Ile Ile Cys Arg Arg 
65                  70                  75                  80  


Arg Trp Arg Glu Pro Pro Pro Arg Leu Leu Trp Gly Cys Leu Met Pro 
                85                  90                  95      


Arg Ala Gln Pro Leu Leu His Val Thr Ala Tyr Glu Asn Thr Gly His 
            100                 105                 110         


Trp Glu Arg Leu Ala Ser Val Val Ser Ser Lys Thr Gln Gln Pro Thr 
        115                 120                 125             


Val Ile Ser His Ser Ser Ile Ser Ile Thr Phe Ser His Tyr Pro Pro 
    130                 135                 140                 


Ala Thr Leu Asp Ser Phe Leu Val Leu Glu Pro Ile Lys Leu Phe Pro 
145                 150                 155                 160 


Val Ser Ser Leu Arg Ser Pro Leu Cys Leu Asn Cys Gly Ser Cys Arg 
                165                 170                 175     


Glu Ser Ile Arg Ile Ser Gly Glu Leu Ile Gly Asn Ala His Ser Pro 
            180                 185                 190         


Ala Pro Pro Arg Thr Pro Glu Leu Glu Thr Leu Gly Trp Asp Lys Gln 
        195                 200                 205             


Ala Val Leu Ser Gly Ala Gln Val Ile Leu Val Cys Ala Glu Val 
    210                 215                 220             


<210>  1459
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9__Homo_sapiens__NP_001728

<400>  1459

Met Ser Ala Cys Arg Ser Phe Ala Val Ala Ile Cys Ile Leu Glu Ile 
1               5                   10                  15      


Ser Ile Leu Thr Ala Gln Tyr Thr Thr Ser Tyr Asp Pro Glu Leu Thr 
            20                  25                  30          


Glu Ser Ser Gly Ser Ala Ser His Ile Asp Cys Arg Met Ser Pro Trp 
        35                  40                  45              


Ser Glu Trp Ser Gln Cys Asp Pro Cys Leu Arg Gln Met Phe Arg Ser 
    50                  55                  60                  


Arg Ser Ile Glu Val Phe Gly Gln Phe Asn Gly Lys Arg Cys Thr Asp 
65                  70                  75                  80  


Ala Val Gly Asp Arg Arg Gln Cys Val Pro Thr Glu Pro Cys Glu Asp 
                85                  90                  95      


Ala Glu Asp Asp Cys Gly Asn Asp Phe Gln Cys Ser Thr Gly Arg Cys 
            100                 105                 110         


Ile Lys Met Arg Leu Arg Cys Asn Gly Asp Asn Asp Cys Gly Asp Phe 
        115                 120                 125             


Ser Asp Glu Asp Asp Cys Glu Ser Glu Pro Arg Pro Pro Cys Arg Asp 
    130                 135                 140                 


Arg Val Val Glu Glu Ser Glu Leu Ala Arg Thr Ala Gly Tyr Gly Ile 
145                 150                 155                 160 


Asn Ile Leu Gly Met Asp Pro Leu Ser Thr Pro Phe Asp Asn Glu Phe 
                165                 170                 175     


Tyr Asn Gly Leu Cys Asn Arg Asp Arg Asp Gly Asn Thr Leu Thr Tyr 
            180                 185                 190         


Tyr Arg Arg Pro Trp Asn Val Ala Ser Leu Ile Tyr Glu Thr Lys Gly 
        195                 200                 205             


Glu Lys Asn Phe Arg Thr Glu His Tyr Glu Glu Gln Ile Glu Ala Phe 
    210                 215                 220                 


Lys Ser Ile Ile Gln Glu Lys Thr Ser Asn Phe Asn Ala Ala Ile Ser 
225                 230                 235                 240 


Leu Lys Phe Thr Pro Thr Glu Thr Asn Lys Ala Glu Gln Cys Cys Glu 
                245                 250                 255     


Glu Thr Ala Ser Ser Ile Ser Leu His Gly Lys Gly Ser Phe Arg Phe 
            260                 265                 270         


Ser Tyr Ser Lys Asn Glu Thr Tyr Gln Leu Phe Leu Ser Tyr Ser Ser 
        275                 280                 285             


Lys Lys Glu Lys Met Phe Leu His Val Lys Gly Glu Ile His Leu Gly 
    290                 295                 300                 


Arg Phe Val Met Arg Asn Arg Asp Val Val Leu Thr Thr Thr Phe Val 
305                 310                 315                 320 


Asp Asp Ile Lys Ala Leu Pro Thr Thr Tyr Glu Lys Gly Glu Tyr Phe 
                325                 330                 335     


Ala Phe Leu Glu Thr Tyr Gly Thr His Tyr Ser Ser Ser Gly Ser Leu 
            340                 345                 350         


Gly Gly Leu Tyr Glu Leu Ile Tyr Val Leu Asp Lys Ala Ser Met Lys 
        355                 360                 365             


Arg Lys Gly Val Glu Leu Lys Asp Ile Lys Arg Cys Leu Gly Tyr His 
    370                 375                 380                 


Leu Asp Val Ser Leu Ala Phe Ser Glu Ile Ser Val Gly Ala Glu Phe 
385                 390                 395                 400 


Asn Lys Asp Asp Cys Val Lys Arg Gly Glu Gly Arg Ala Val Asn Ile 
                405                 410                 415     


Thr Ser Glu Asn Leu Ile Asp Asp Val Val Ser Leu Ile Arg Gly Gly 
            420                 425                 430         


Thr Arg Lys Tyr Ala Phe Glu Leu Lys Glu Lys Leu Leu Arg Gly Thr 
        435                 440                 445             


Val Ile Asp Val Thr Asp Phe Val Asn Trp Ala Ser Ser Ile Asn Asp 
    450                 455                 460                 


Ala Pro Val Leu Ile Ser Gln Lys Leu Ser Pro Ile Tyr Asn Leu Val 
465                 470                 475                 480 


Pro Val Lys Met Lys Asn Ala His Leu Lys Lys Gln Asn Leu Glu Arg 
                485                 490                 495     


Ala Ile Glu Asp Tyr Ile Asn Glu Phe Ser Val Arg Lys Cys His Thr 
            500                 505                 510         


Cys Gln Asn Gly Gly Thr Val Ile Leu Met Asp Gly Lys Cys Leu Cys 
        515                 520                 525             


Ala Cys Pro Phe Lys Phe Glu Gly Ile Ala Cys Glu Ile Ser Lys Gln 
    530                 535                 540                 


Lys Ile Ser Glu Gly Leu Pro Ala Leu Glu Phe Pro Asn Glu Lys 
545                 550                 555                 


<210>  1460
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf106__Homo_sapiens__NP_001012733

<400>  1460

Met Ala Tyr Val Ala Leu Ser Asp Lys Pro His Leu Ser Gly Glu Val 
1               5                   10                  15      


Gly Glu Glu Ala Cys Ser Ser Trp Asn Pro Pro Leu Phe Ser Pro Arg 
            20                  25                  30          


Pro Leu Pro Arg Leu Trp Pro Leu Pro Gly Thr Pro Phe Leu Pro Ile 
        35                  40                  45              


Arg Ala Leu Pro Phe Ser Ala Ser Ser Ser Gly Lys Ser Ser Leu Val 
    50                  55                  60                  


Pro Ser Pro Ser Ser Ser Ala His Ser Gly Phe Arg Thr Pro Cys Leu 
65                  70                  75                  80  


Gly Pro Asp Cys Leu Leu Cys Thr Gln Gly Cys Glu Leu His Glu Gly 
                85                  90                  95      


Arg Asn His Met Ala Val His Ser Cys Val Ala Arg Ala Trp Pro Gly 
            100                 105                 110         


Asp Pro Gln Glu Val Arg His Leu Asn Pro Leu Leu Cys Asp Pro Gly 
        115                 120                 125             


Ser Gln Val Glu Pro Ser Trp Pro Trp His Pro Gly Leu Glu Gln Ala 
    130                 135                 140                 


Ala Ala Ser Trp Val Gly Asn His Val Ser Pro Ala His Arg Gln Ala 
145                 150                 155                 160 


Leu Arg Gly His Ser Leu Gly Ser Ala Leu Arg Ala Leu Met Pro Gly 
                165                 170                 175     


Gly His Cys Pro Leu Cys Val Pro Cys Lys Arg Gly Cys Asn Leu Arg 
            180                 185                 190         


Gly Gly Arg Gly Lys His Gly Pro Arg Pro Cys Cys Pro Leu Leu Arg 
        195                 200                 205             


Lys Phe Pro Val Leu Pro Val His Pro Trp Pro Phe Pro Cys Ala Val 
    210                 215                 220                 


Trp Asp Ser Gly Trp Ser Cys Arg 
225                 230         


<210>  1461
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf135__Homo_sapiens__NP_001010940

<400>  1461

Met Asp Ser Leu Asp Arg Ser Cys Gln Asp Trp Cys Asp Arg Lys Gln 
1               5                   10                  15      


His Trp Leu Glu Ile Gly Pro Pro Asp Leu Val Glu Arg Lys Gly Ser 
            20                  25                  30          


Leu Thr Leu Arg Ser His His Lys Lys Tyr Ser Lys Pro Val Leu Val 
        35                  40                  45              


Tyr Ser Trp His Arg Asp Arg Glu Ala Phe Pro Lys Gly Tyr Asp Ile 
    50                  55                  60                  


Glu Gly Pro Glu Lys Val Lys Lys Leu Cys Asn Ser Thr Tyr Arg Arg 
65                  70                  75                  80  


Leu Gly Thr Asp Glu Ser Pro Ile Trp Thr Ser Glu Thr His Glu Lys 
                85                  90                  95      


Leu Ser Gln Met Cys Leu Asn Thr Glu Trp Val Glu Met Lys Ser Lys 
            100                 105                 110         


Ala Leu Leu Asn Glu Glu Thr Val Ser Ser Gly Ile Ile Glu Arg Val 
        115                 120                 125             


Thr Gly Leu Pro Ala Thr Gly Phe Gly Ala Val Phe Pro Arg His Pro 
    130                 135                 140                 


Pro Asp Trp Ser Lys Met Cys Ala Leu Thr Thr Tyr Ser Glu Asp Tyr 
145                 150                 155                 160 


Val Pro Pro Tyr Asp Tyr Gln Pro His Ala Tyr Pro Cys Gln Asp Asp 
                165                 170                 175     


Tyr Ser Ile Val His Arg Lys Cys Arg Ser Gln Phe Thr Asp Leu Asn 
            180                 185                 190         


Gly Ser Lys Arg Phe Gly Ile Asn Thr Trp His Asp Glu Ser Gly Ile 
        195                 200                 205             


Tyr Ala Asn Ser Asp Val Lys Gln Lys Leu Tyr Pro Leu Thr Ser Gly 
    210                 215                 220                 


Pro Ile Val Pro Ile 
225                 


<210>  1462
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf152__Homo_sapiens__NP_001013011

<400>  1462

Met Glu Gly Leu Pro Cys Pro Cys Pro Ala Leu Pro His Phe Trp Gln 
1               5                   10                  15      


Leu Arg Ser His Leu Met Ala Glu Gly Ser Arg Thr Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Pro Pro Leu Ser Ile Gln Phe Leu Arg Ala Gln Tyr Glu Gly 
        35                  40                  45              


Leu Lys Arg Gln Gln Arg Thr Gln Ala His Leu Leu Val Leu Pro Lys 
    50                  55                  60                  


Gly Gly Asn Thr Pro Ala Pro Ala Glu Ser Met Val Asn Ala Val Trp 
65                  70                  75                  80  


Ile Asn Lys Glu Arg Arg Ser Ser Leu Ser Leu Glu Glu Ala Asp Ser 
                85                  90                  95      


Glu Val Glu Gly Arg Leu Glu Glu Ala Ala Gln Gly Cys Leu Gln Ala 
            100                 105                 110         


Pro Lys Ser Pro Trp His Thr His Leu Glu Met His Cys Leu Val Gln 
        115                 120                 125             


Thr Ser Pro Gln Asp Thr Ser His Gln Val His His Arg Gly Lys Leu 
    130                 135                 140                 


Val Gly Ser Asp Gln Arg Leu Pro Pro Glu Gly Asp Thr His Leu Phe 
145                 150                 155                 160 


Glu Thr Asn Gln Met Thr Gln Gln Gly Thr Gly Ile Pro Glu Ala Ala 
                165                 170                 175     


Gln Leu Pro Cys Gln Val Gly Asn Thr Gln Thr Lys Ala Val Glu Ser 
            180                 185                 190         


Gly Leu Lys Phe Ser Thr Gln Cys Pro Leu Ser Ile Lys Asn Pro His 
        195                 200                 205             


Arg Ser Gly Lys Pro Ala Tyr Tyr Pro Phe Pro Gln Arg Lys Thr Pro 
    210                 215                 220                 


Arg Ile Ser Gln Ala Ala Arg Asn Leu Gly Leu Tyr Gly Ser Ala 
225                 230                 235                 


<210>  1463
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf156__Homo_sapiens__NP_057565

<400>  1463

Met Arg Gly Leu Glu Glu Ser Gly Pro Arg Pro Thr Ala Thr Pro Cys 
1               5                   10                  15      


Gly Cys Val Lys Pro Ala Leu Glu Thr Gly Asn Leu Leu Thr Glu Pro 
            20                  25                  30          


Val Gly Tyr Leu Glu Ser Cys Phe Ser Ala Lys Asn Gly Thr Pro Arg 
        35                  40                  45              


Gln Pro Ser Ile Cys Ser Tyr Ser Arg Ala Cys Leu Arg Ile Arg Lys 
    50                  55                  60                  


Arg Ile Phe Asn Asn Pro Glu His Ser Leu Met Gly Leu Glu Gln Phe 
65                  70                  75                  80  


Ser His Val Trp Ile Leu Phe Val Phe His Lys Asn Gly His Leu Ser 
                85                  90                  95      


Cys Lys Ala Lys Val Gln Pro Pro Arg Leu Asn Gly Ala Lys Thr Gly 
            100                 105                 110         


Val Phe Ser Thr Arg Ser Pro His Arg Pro Asn Ala Ile Gly Leu Thr 
        115                 120                 125             


Leu Ala Lys Leu Glu Lys Val Glu Gly Gly Ala Ile Tyr Leu Ser Gly 
    130                 135                 140                 


Ile Asp Met Ile His Gly Thr Pro Val Leu Asp Ile Lys Pro Tyr Ile 
145                 150                 155                 160 


Ala Glu Tyr Asp Ser Pro Gln Asn Val Met Glu Pro Leu Ala Asp Phe 
                165                 170                 175     


Asn Leu Gln Asn Asn Gln His Thr Pro Asn Thr Val Ser Gln Ser Asp 
            180                 185                 190         


Ser Lys Thr Asp Ser Cys Asp Gln Arg Gln Leu Ser Gly Cys Asp Glu 
        195                 200                 205             


Pro Gln Pro His His Ser Thr Lys Arg Lys Pro Lys Cys Pro Glu Asp 
    210                 215                 220                 


Arg Thr Ser Glu Glu Asn Tyr Leu Thr His Ser Asp Thr Ala Arg Ile 
225                 230                 235                 240 


Gln Gln Ala Phe Pro Met His Arg Glu Ile Ala Val Asp Phe Gly Leu 
                245                 250                 255     


Glu Ser Arg Arg Asp Gln Ser Ser Ser Val Ala Glu Glu Gln Ile Gly 
            260                 265                 270         


Pro Tyr Cys Pro Glu Lys Ser Phe Ser Glu Lys Gly Thr Asp Lys Lys 
        275                 280                 285             


Leu Glu Arg Val Glu Gly Ala Ala Val Leu Gln Gly Ser Arg Ala Glu 
    290                 295                 300                 


Thr Gln Pro Met Ala Pro His Cys Pro Ala Gly Arg Ala Asp Gly Ala 
305                 310                 315                 320 


Pro Arg Ser Val Val Pro Ala Trp Val Thr Glu Ala Pro Val Ala Thr 
                325                 330                 335     


Leu Glu Val Arg Phe Thr Pro His Ala Glu Met Asp Leu Gly Gln Leu 
            340                 345                 350         


Ser Ser Gln Asp Val Gly Gln Ala Ser Phe Lys Tyr Phe Gln Ser Ala 
        355                 360                 365             


Glu Glu Ala Lys Arg Ala Ile Glu Ala Val Leu Ser Ala Asp Pro Arg 
    370                 375                 380                 


Ser Val Tyr Arg Arg Lys Leu Cys Gln Asp Arg Leu Phe Tyr Phe Thr 
385                 390                 395                 400 


Val Asp Ile Ala His Val Thr Cys Trp Phe Gly Asp Gly Phe Ala Glu 
                405                 410                 415     


Val Leu Arg Ile Lys Pro Ala Ser Glu Pro Val His Met Thr Gly Pro 
            420                 425                 430         


Val Gly Ser Leu Val Ser Leu Gly Ser 
        435                 440     


<210>  1464
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf170__Homo_sapiens__NP_001001709

<400>  1464

Met Trp Ser Arg Arg Gly Leu Gly Val Ser Arg Ala Pro Leu His Leu 
1               5                   10                  15      


Leu Leu Gly Val Trp Gly Pro Ser Gly Arg Thr Gly Gly Gln Arg Lys 
            20                  25                  30          


Gly Ala Ser Leu Ala Arg Pro Gly Arg Gly Gly Leu Ala Ser Cys Ser 
        35                  40                  45              


Val Gly Ala Asn Gly Lys Arg Asp Val Leu Phe Leu Arg Lys Thr Leu 
    50                  55                  60                  


Thr Asn Thr Val Glu Asp Ile Gln Ile Asp Asn Phe Arg Arg Lys Ser 
65                  70                  75                  80  


Asp Leu Gly Val Gly Ser Pro Asp Trp Lys Asn Leu Leu Ile Asp Val 
                85                  90                  95      


Thr Arg Glu Asp His Glu Asn Ser Gln Asn Asn Ser Lys Arg Arg Cys 
            100                 105                 110         


Lys Val Asn Cys Glu Thr Asp Gln Arg 
        115                 120     


<210>  1465
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf171__Homo_sapiens__NP_001269886

<400>  1465

Met Pro Glu Ala Arg Ser Ser Gly Pro Asp Leu Thr Arg Trp Arg Lys 
1               5                   10                  15      


Gln Gln Gln Pro Val Arg Arg Thr Val Ser Gln Val Cys Pro Pro Pro 
            20                  25                  30          


Arg Arg Pro Leu Thr Val Ala Asp Ile Arg Ser Gly Met Glu Asn Glu 
        35                  40                  45              


Arg Leu Gly Val Val Arg Asp Ser Met Phe Gln Asn Pro Leu Ile Val 
    50                  55                  60                  


Lys Ala Glu Leu Gly Lys Pro Arg Glu Arg Ser Tyr Ser Leu Pro Gly 
65                  70                  75                  80  


Ile Asn Phe Asn Tyr Gly Leu Tyr Ile Arg Gly Leu Asp Gly Gly Val 
                85                  90                  95      


Pro Glu Ala Ile Gly Arg Trp Asn Val Phe Lys Gln Gln Pro Thr Cys 
            100                 105                 110         


Pro His Glu Leu Thr Arg Asn Tyr Ile Ala Met Asn Arg Gly Ala Val 
        115                 120                 125             


Lys Ala Gly Leu Val Thr Ala Arg Glu Asn Leu Leu Tyr Arg Gln Leu 
    130                 135                 140                 


Asn Asp Ile Arg Ile Ser Asp Gln Asp Asp Arg Arg Met Lys Lys Glu 
145                 150                 155                 160 


Pro Pro Pro Leu Pro Pro Asn Met Thr Phe Gly Ile Arg Ala Arg Pro 
                165                 170                 175     


Ser Thr Pro Phe Phe Asp Leu Leu Gln His Arg Tyr Leu Gln Leu Trp 
            180                 185                 190         


Val Gln Glu Gln Lys Ala Thr Gln Lys Ala Ile Lys Leu Glu Lys Lys 
        195                 200                 205             


Gln Lys Val Val Leu Gly Lys Leu Tyr Glu Thr Arg Ser Ser Gln Leu 
    210                 215                 220                 


Arg Lys Tyr Lys Pro Pro Val Lys Leu Asp Thr Leu Trp His Met Pro 
225                 230                 235                 240 


His Phe Gln Lys Val Gly Arg His Leu Asp Thr Phe Pro Thr Glu Ala 
                245                 250                 255     


Asp Arg Gln Arg Ala Leu Lys Ala His Arg Glu Glu Cys Ala Val Arg 
            260                 265                 270         


Gln Gly Thr Leu Arg Met Gly Asn Tyr Thr His Pro 
        275                 280                 


<210>  1466
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf3__Homo_sapiens__NP_001180260

<400>  1466

Met Asp Ile Gln Leu Asp Pro Ala Arg Asp Asp Leu Pro Leu Met Ala 
1               5                   10                  15      


Asn Thr Ser His Ile Leu Val Lys His Tyr Val Leu Asp Leu Asp Val 
            20                  25                  30          


Asp Phe Glu Ser Gln Val Ile Glu Gly Thr Ile Val Leu Phe Leu Glu 
        35                  40                  45              


Asp Gly Asn Arg Phe Lys Lys Gln Asn Ser Ser Ile Glu Glu Ala Cys 
    50                  55                  60                  


Gln Ser Glu Ser Asn Lys Ala Cys Lys Phe Gly Met Pro Glu Pro Cys 
65                  70                  75                  80  


His Ile Pro Val Thr Asn Ala Arg Thr Phe Ser Ser Glu Met Glu Tyr 
                85                  90                  95      


Asn Asp Phe Ala Ile Cys Ser Lys Gly Glu Lys Asp Thr Ser Asp Lys 
            100                 105                 110         


Asp Gly Asn His Asp Asn Gln Glu His Ala Ser Gly Ile Ser Ser Ser 
        115                 120                 125             


Lys Tyr Cys Cys Asp Thr Gly Asn His Gly Ser Glu Asp Phe Leu Leu 
    130                 135                 140                 


Val Leu Asp Cys Cys Asp Leu Ser Val Leu Lys Val Glu Glu Val Asp 
145                 150                 155                 160 


Val Ala Ala Val Pro Gly Leu Glu Lys Phe Thr Arg Ser Pro Glu Leu 
                165                 170                 175     


Thr Val Val Ser Glu Glu Phe Arg Asn Gln Ile Val Arg Glu Leu Val 
            180                 185                 190         


Thr Leu Pro Ala Asn Arg Trp Arg Glu Gln Leu Asp Tyr Tyr Ala Arg 
        195                 200                 205             


Cys Ser Gln Ala Pro Gly Cys Gly Glu Leu Leu Phe Asp Thr Asp Thr 
    210                 215                 220                 


Trp Ser Leu Gln Ile Arg Lys Thr Gly Ala Gln Thr Ala Thr Asp Phe 
225                 230                 235                 240 


Pro His Ala Ile Arg Ile Trp Tyr Lys Thr Lys Pro Glu Gly Arg Ser 
                245                 250                 255     


Val Thr Trp Thr Ser Asp Gln Ser Gly Arg Pro Cys Val Tyr Thr Val 
            260                 265                 270         


Gly Ser Pro Ile Asn Asn Arg Ala Leu Phe Pro Cys Gln Glu Pro Pro 
        275                 280                 285             


Val Ala Met Ser Thr Trp Gln Ala Thr Val Arg Ala Ala Ala Ser Phe 
    290                 295                 300                 


Val Val Leu Met Ser Gly Glu Asn Ser Ala Lys Pro Thr Gln Leu Trp 
305                 310                 315                 320 


Glu Glu Cys Ser Ser Trp Tyr Tyr Tyr Val Thr Met Pro Met Pro Ala 
                325                 330                 335     


Ser Thr Phe Thr Ile Ala Val Gly Cys Trp Thr Glu Met Lys Met Glu 
            340                 345                 350         


Thr Trp Ser Ser Asn Asp Leu Ala Thr Glu Arg Pro Phe Ser Pro Ser 
        355                 360                 365             


Glu Ala Asn Phe Arg His Val Gly Val Cys Ser His Met Glu Tyr Pro 
    370                 375                 380                 


Cys Arg Phe Gln Asn Ala Ser Ala Thr Thr Gln Glu Ile Ile Pro His 
385                 390                 395                 400 


Arg Val Phe Ala Pro Val Cys Leu Thr Gly Ala Cys Gln Glu Thr Leu 
                405                 410                 415     


Leu Arg Leu Ile Pro Pro Cys Leu Ser Ala Ala His Ser Val Leu Gly 
            420                 425                 430         


Ala His Pro Phe Ser Arg Leu Asp Val Leu Ile Val Pro Ala Asn Phe 
        435                 440                 445             


Pro Ser Leu Gly Met Ala Ser Pro His Ile Met Phe Leu Ser Gln Ser 
    450                 455                 460                 


Ile Leu Thr Gly Gly Asn His Leu Cys Gly Thr Arg Leu Cys His Glu 
465                 470                 475                 480 


Ile Ala His Ala Trp Phe Gly Leu Ala Ile Gly Ala Arg Asp Trp Thr 
                485                 490                 495     


Glu Glu Trp Leu Ser Glu Gly Phe Ala Thr His Leu Glu Asp Val Phe 
            500                 505                 510         


Trp Ala Thr Ala Gln Gln Leu Ala Pro Tyr Glu Ala Arg Glu Gln Gln 
        515                 520                 525             


Glu Leu Arg Ala Cys Leu Arg Trp Arg Arg Leu Gln Asp Glu Met Gln 
    530                 535                 540                 


Cys Ser Pro Glu Glu Met Gln Val Leu Arg Phe Pro His Val Gly Gly 
545                 550                 555                 560 


Cys Ser Gly Ser Phe Ser 
                565     


<210>  1467
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf43__Homo_sapiens__NP_001265558

<400>  1467

Met Asp Leu Pro Asp Glu Ser Gln Trp Asp Glu Thr Thr Cys Gly Leu 
1               5                   10                  15      


Ala Val Cys Gln His Pro Gln Cys Trp Ala Thr Ile Arg Arg Ile Glu 
            20                  25                  30          


Arg Gly His Pro Arg Ile Leu Gly Ser Ser Cys Lys Thr Pro Leu Asp 
        35                  40                  45              


Ala Glu Asp Lys Leu Pro Val Leu Thr Val Val Asp Ile Leu Asp Ser 
    50                  55                  60                  


Gly Phe Ala Ala His His Leu Pro Glu Cys Thr Phe Thr Lys Ala His 
65                  70                  75                  80  


Ser Leu Leu Ser Gln Ser Ser Lys Phe Tyr Ser Lys Phe His Gly Arg 
                85                  90                  95      


Pro Pro Lys Gly Leu Pro Asp Lys Ser Leu Ile Asn Cys Thr Asn Arg 
            100                 105                 110         


Leu Pro Lys Phe Pro Val Leu Asn Leu Asn Glu Thr Gln Leu Pro Cys 
        115                 120                 125             


Pro Glu Asp Val Arg Asn Met Val Val Leu Trp Ile Pro Glu Glu Thr 
    130                 135                 140                 


Glu Ile His Val Ser Gln His Gly Lys Lys Lys Arg Lys Asn Ser Ala 
145                 150                 155                 160 


Val Lys Ser Lys Ser Phe Leu Gly Leu Ser Gly Asn Gln Ser Ala Gly 
                165                 170                 175     


Thr Arg Val Gly Thr Pro Gly Met Ile Val Pro Pro Pro Thr Pro Val 
            180                 185                 190         


Gln Leu Ser Glu Gln Phe Ser Ser Asp Phe Leu Pro Leu Trp Ala Gln 
        195                 200                 205             


Ser Glu Ala Leu Pro Gln Asp Leu Leu Lys Glu Leu Leu Pro Gly Gly 
    210                 215                 220                 


Lys Gln Thr Met Leu Cys Pro Glu Met Lys Ile Lys Leu Ala Met Met 
225                 230                 235                 240 


Lys Lys Asn Leu Pro Leu Glu Lys Asn Arg Pro Asp Ser Val Ile Ser 
                245                 250                 255     


Ser Lys Met Phe Leu Ser Ile His Arg Leu Thr Leu Glu Arg Pro Ala 
            260                 265                 270         


Leu Arg Tyr Pro Glu Arg Leu Lys Lys Leu His Asn Leu Lys Thr Glu 
        275                 280                 285             


Gly Tyr Arg Lys Gln Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Lys Lys Val Lys Thr Pro Ile Lys Lys Gln Glu Ala Lys Lys Lys Ala 
305                 310                 315                 320 


Lys Ser Asp Pro Gly Ile Gln Ser Thr Ser His Lys His Pro Val Thr 
                325                 330                 335     


Thr Val His Asp Arg Leu Tyr Gly Tyr Arg Thr Leu Pro Gly Gln Asn 
            340                 345                 350         


Ser Asp Met Lys Gln Gln Gln Gln Met Glu Lys Gly Thr Thr Ser Lys 
        355                 360                 365             


Gln Asp Ser Thr Glu Arg Pro Lys Met Asn Tyr Tyr Asp His Ala Asp 
    370                 375                 380                 


Phe His His Ser Val Lys Ser Pro Glu Leu Tyr Glu Thr Glu Pro Thr 
385                 390                 395                 400 


Asn Lys Asp Ile Ser Ala Pro Val Asp Ala Val Pro Glu Ala Gln Ala 
                405                 410                 415     


Ala Arg Gln Lys Lys Ile Ser Phe Asn Phe Ser Glu Ile Met Ala Ser 
            420                 425                 430         


Thr Gly Trp Asn Ser Glu Leu Lys Leu Leu Arg Ile Leu Gln Asp Thr 
        435                 440                 445             


Asp Asp Glu Asp Glu Glu Asp Gln Ser Ser Gly Ala Glu 
    450                 455                 460     


<210>  1468
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf66__Homo_sapiens__NP_689782

<400>  1468

Met Arg His Ser Val Ala Arg Pro Thr Arg Leu Pro Arg Arg Leu Ser 
1               5                   10                  15      


Pro Phe Trp Asp Pro Ala Thr Cys Lys Asn Leu Glu Gly Gly Ala Gly 
            20                  25                  30          


Glu Val Val Arg Gly Arg Asp Pro Arg Arg Leu Arg Thr Ser Arg Ser 
        35                  40                  45              


Thr Glu Ile Leu Gly Glu Asp Leu Ala Gly Pro Ser Ala Gly Ala Ala 
    50                  55                  60                  


Ala Arg Pro Ala Ala Pro Pro Pro Gln Pro Arg Glu Pro Gly Ala Pro 
65                  70                  75                  80  


Gly Leu Arg Arg Ala Pro Pro Arg Thr Arg Met Asp Ser Ser Gly Leu 
                85                  90                  95      


Gly Pro Cys Ser Glu Ala Pro Leu His Thr Ser Ala Gly Leu Ser Gly 
            100                 105                 110         


Arg Asn Leu Arg Ala Ala Gly Gly Val Leu Pro Val Asp Leu Glu Arg 
        115                 120                 125             


Glu Arg Ala Ala Leu Cys Ala Arg Gln Ser Gly His Gly Pro Pro Ala 
    130                 135                 140                 


Val Arg Trp Leu Leu Gly Ser Arg Gly Ala Glu Ser Gly Gly Leu Ala 
145                 150                 155                 160 


Arg Arg Arg Val Ala Ala Glu His Ala Gln Pro Ser Ala Asn Leu Val 
                165                 170                 175     


Cys Arg Ser Ala Leu Glu Thr Ser Ala Phe Pro Pro Ser Lys Pro Lys 
            180                 185                 190         


Ser Pro Arg Gly Arg Val Arg Ala Arg Ser Ser Asp Gly Arg Leu Arg 
        195                 200                 205             


His Pro Ala Trp Arg Ala Gly Ser Gly Gly Arg Gly Gly Arg Gly Pro 
    210                 215                 220                 


Ser Ala Glu Leu Ala Ser Arg Tyr Trp Gly Arg Arg Arg Ala Leu Pro 
225                 230                 235                 240 


Gly Ala Ala Asp Leu Arg Pro Lys Gly Ala Arg Ala Asp Asp Arg Arg 
                245                 250                 255     


Pro Leu Arg Ala Gly Arg Lys Leu His Leu Pro Glu Ala Ala Arg Leu 
            260                 265                 270         


Pro Gly Asn Val Gly Lys Ser Gly Glu Pro His Lys Ala Gly Glu Val 
        275                 280                 285             


Gly Asn His Pro Arg Asp Ser 
    290                 295 


<210>  1469
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf72__Homo_sapiens__NP_060795

<400>  1469

Met Ser Thr Leu Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Lys Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Glu Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Ile Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ser Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Glu Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn Ala Ile 
    210                 215                 220                 


Ser Ser His Leu Gln Thr Cys Gly Cys Ser Val Val Val Gly Ser Ser 
225                 230                 235                 240 


Ala Glu Lys Val Asn Lys Ile Val Arg Thr Leu Cys Leu Phe Leu Thr 
                245                 250                 255     


Pro Ala Glu Arg Lys Cys Ser Arg Leu Cys Glu Ala Glu Ser Ser Phe 
            260                 265                 270         


Lys Tyr Glu Ser Gly Leu Phe Val Gln Gly Leu Leu Lys Asp Ser Thr 
        275                 280                 285             


Gly Ser Phe Val Leu Pro Phe Arg Gln Val Met Tyr Ala Pro Tyr Pro 
    290                 295                 300                 


Thr Thr His Ile Asp Val Asp Val Asn Thr Val Lys Gln Met Pro Pro 
305                 310                 315                 320 


Cys His Glu His Ile Tyr Asn Gln Arg Arg Tyr Met Arg Ser Glu Leu 
                325                 330                 335     


Thr Ala Phe Trp Arg Ala Thr Ser Glu Glu Asp Met Ala Gln Asp Thr 
            340                 345                 350         


Ile Ile Tyr Thr Asp Glu Ser Phe Thr Pro Asp Leu Asn Ile Phe Gln 
        355                 360                 365             


Asp Val Leu His Arg Asp Thr Leu Val Lys Ala Phe Leu Asp Gln Val 
    370                 375                 380                 


Phe Gln Leu Lys Pro Gly Leu Ser Leu Arg Ser Thr Phe Leu Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Val Leu His Arg Lys Ala Leu Thr Leu Ile Lys Tyr Ile 
                405                 410                 415     


Glu Asp Asp Thr Gln Lys Gly Lys Lys Pro Phe Lys Ser Leu Arg Asn 
            420                 425                 430         


Leu Lys Ile Asp Leu Asp Leu Thr Ala Glu Gly Asp Leu Asn Ile Ile 
        435                 440                 445             


Met Ala Leu Ala Glu Lys Ile Lys Pro Gly Leu His Ser Phe Ile Phe 
    450                 455                 460                 


Gly Arg Pro Phe Tyr Thr Ser Val Gln Glu Arg Asp Val Leu Met Thr 
465                 470                 475                 480 


Phe 
    


<210>  1470
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf85__Homo_sapiens__NP_872311

<400>  1470

Met Ser Ser Gln Lys Gly Asn Val Ala Arg Ser Arg Pro Gln Lys His 
1               5                   10                  15      


Gln Asn Thr Phe Ser Phe Lys Asn Asp Lys Phe Asp Lys Ser Val Gln 
            20                  25                  30          


Thr Lys Lys Ile Asn Ala Lys Leu His Asp Gly Val Cys Gln Arg Cys 
        35                  40                  45              


Lys Glu Val Leu Glu Trp Arg Val Lys Tyr Ser Lys Tyr Lys Pro Leu 
    50                  55                  60                  


Ser Lys Pro Lys Lys Cys Val Lys Cys Leu Gln Lys Thr Val Lys Asp 
65                  70                  75                  80  


Ser Tyr His Ile Met Cys Arg Pro Cys Ala Cys Glu Leu Glu Val Cys 
                85                  90                  95      


Ala Lys Cys Gly Lys Lys Glu Asp Ile Val Ile Pro Leu Asn Lys Glu 
            100                 105                 110         


Thr Glu Lys Ile Glu His Thr Glu Asn Asn Leu Ser Ser Asn His Arg 
        115                 120                 125             


Arg Ser Cys Arg Arg Asn Glu Glu Ser Asp Asp Asp Leu Asp Phe Asp 
    130                 135                 140                 


Ile Asp Leu Glu Asp Thr Gly Gly Asp His Gln Met Asn 
145                 150                 155         


<210>  1471
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf91__Homo_sapiens__NP_694590

<400>  1471

Met Ala Cys Glu Pro Gln Val Asp Pro Gly Ala Thr Gly Pro Leu Pro 
1               5                   10                  15      


Pro Ser Ser Pro Gly Trp Ser Ala Leu Pro Gly Gly Ser Pro Pro Gly 
            20                  25                  30          


Trp Gly Gln Glu Leu His Asn Gly Gln Val Leu Thr Val Leu Arg Ile 
        35                  40                  45              


Asp Asn Thr Cys Ala Pro Ile Ser Phe Asp Leu Gly Ala Ala Glu Glu 
    50                  55                  60                  


Gln Leu Gln Thr Trp Gly Ile Gln Val Pro Ala Asp Gln Tyr Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Ser Ala Leu Leu Glu Pro Gln Val Arg Arg Tyr Ile Ile 
                85                  90                  95      


Tyr Asn Ser Arg Pro Met Arg Leu Ala Phe Ala Val Val Phe Tyr Val 
            100                 105                 110         


Val Val Trp Ala Asn Ile Tyr Ser Thr Ser Gln Met Phe Ala Leu Gly 
        115                 120                 125             


Asn His Trp Ala Gly Met Leu Leu Val Thr Leu Ala Ala Val Ser Leu 
    130                 135                 140                 


Thr Leu Thr Leu Val Leu Val Phe Glu Arg His Gln Lys Lys Ala Asn 
145                 150                 155                 160 


Thr Asn Thr Asp Leu Arg Leu Ala Ala Ala Asn Gly Ala Leu Leu Arg 
                165                 170                 175     


His Arg Val Leu Leu Gly Val Thr Asp Thr Val Glu Gly Cys Gln Ser 
            180                 185                 190         


Val Ile Gln Leu Trp Phe Val Tyr Phe Asp Leu Glu Asn Cys Val Gln 
        195                 200                 205             


Phe Leu Ser Asp His Val Gln Glu Met Lys Thr Ser Gln Glu Ser Leu 
    210                 215                 220                 


Leu Arg Ser Arg Leu Ser Gln Leu Cys Val Val Met Glu Thr Gly Val 
225                 230                 235                 240 


Ser Pro Ala Thr Ala Glu Gly Pro Glu Asn Leu Glu Asp Ala Pro Leu 
                245                 250                 255     


Leu Pro Gly Asn Ser Cys Pro Asn Glu Arg Pro Leu Met Gln Thr Glu 
            260                 265                 270         


Leu His Gln Leu Val Pro Glu Ala Glu Pro Glu Glu Met Ala Arg Gln 
        275                 280                 285             


Leu Leu Ala Val Phe Gly Gly Tyr Tyr Ile Arg Leu Leu Val Thr Ser 
    290                 295                 300                 


Gln Leu Pro Gln Ala Met Gly Thr Arg His Thr Asn Ser Pro Arg Ile 
305                 310                 315                 320 


Pro Cys Pro Cys Gln Leu Ile Glu Ala Tyr Ile Leu Gly Thr Gly Cys 
                325                 330                 335     


Cys Pro Phe Leu Ala Arg 
            340         


<210>  1472
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9orf9__Homo_sapiens__NP_061829

<400>  1472

Met Asn Glu Val Lys Glu Ser Leu Arg Ser Ile Glu Gln Lys Tyr Lys 
1               5                   10                  15      


Leu Phe Gln Gln Gln Gln Leu Thr Phe Thr Ala Ala Leu Glu His Cys 
            20                  25                  30          


Arg Glu Asn Ala His Asp Lys Ile Arg Pro Ile Ser Ser Ile Gly Gln 
        35                  40                  45              


Val Gln Ser Tyr Met Glu His Tyr Cys Asn Ser Ser Thr Asp Arg Arg 
    50                  55                  60                  


Val Leu Leu Met Phe Leu Asp Ile Cys Ser Glu Leu Asn Lys Leu Cys 
65                  70                  75                  80  


Gln His Phe Glu Ala Val His Ser Gly Thr Pro Val Thr Asn Asn Leu 
                85                  90                  95      


Leu Glu Lys Cys Lys Thr Leu Val Ser Gln Ser Asn Asp Leu Ser Ser 
            100                 105                 110         


Leu Arg Ala Lys Tyr Pro His Asp Val Val Asn His Leu Ser Cys Asp 
        115                 120                 125             


Glu Ala Arg Asn His Tyr Gly Gly Val Val Ser Leu Ile Pro Leu Ile 
    130                 135                 140                 


Leu Asp Leu Met Lys Glu Trp Ile Ala His Ser Glu Lys Leu Pro Arg 
145                 150                 155                 160 


Lys Val Leu Gln His Gly Thr Thr 
                165             


<210>  1473
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA10__Homo_sapiens__NP_001076003

<400>  1473

Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln Ala Asn Phe Ile 
1               5                   10                  15      


Val Cys Ile Ser Ala Gln Gln Asn Ser Pro Lys Ile His Glu Gly Trp 
            20                  25                  30          


Trp Ala Tyr Lys Glu Val Val Gln Gly Ser Phe Val Pro Val Pro Ser 
        35                  40                  45              


Phe Trp Gly Leu Val Asn Ser Ala Trp Asn Leu Cys Ser Val Gly Lys 
    50                  55                  60                  


Arg Gln Ser Pro Val Asn Ile Glu Thr Ser His Met Ile Phe Asp Pro 
65                  70                  75                  80  


Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly Arg Lys Val Ser Gly 
                85                  90                  95      


Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu Arg Leu Asp Lys Glu 
            100                 105                 110         


His Leu Val Asn Ile Ser Gly Gly Pro Met Thr Tyr Ser His Arg Leu 
        115                 120                 125             


Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp Ser Gln Gly Ser Glu 
    130                 135                 140                 


His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu Val Gln Leu Ile His 
145                 150                 155                 160 


Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu Ala Ala Lys Ser Pro 
                165                 170                 175     


Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys Val Ser Asp Ser Ser 
            180                 185                 190         


Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp Thr Ile Thr Arg Ile 
        195                 200                 205             


Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly Leu Asn Ile Glu Glu 
    210                 215                 220                 


Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr Asp Gly Ser Met Thr 
225                 230                 235                 240 


Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile Ile Met Asn Lys Pro 
                245                 250                 255     


Val Tyr Ile Thr Arg Met Gln Met His Ser Leu Arg Leu Leu Ser Gln 
            260                 265                 270         


Asn Gln Pro Ser Gln Ile Phe Leu Ser Met Ser Asp Asn Phe Arg Pro 
        275                 280                 285             


Val Gln Pro Leu Asn Asn Arg Cys Ile Arg Thr Asn Ile Asn Phe Ser 
    290                 295                 300                 


Leu Gln Gly Lys Asp Cys Pro Asn Asn Arg Ala Gln Lys Leu Gln Tyr 
305                 310                 315                 320 


Arg Val Asn Glu Trp Leu Leu Lys 
                325             


<210>  1474
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA11__Homo_sapiens__NP_001208

<400>  1474

Met Gly Ala Ala Ala Arg Leu Ser Ala Pro Arg Ala Leu Val Leu Trp 
1               5                   10                  15      


Ala Ala Leu Gly Ala Ala Ala His Ile Gly Pro Ala Pro Asp Pro Glu 
            20                  25                  30          


Asp Trp Trp Ser Tyr Lys Asp Asn Leu Gln Gly Asn Phe Val Pro Gly 
        35                  40                  45              


Pro Pro Phe Trp Gly Leu Val Asn Ala Ala Trp Ser Leu Cys Ala Val 
    50                  55                  60                  


Gly Lys Arg Gln Ser Pro Val Asp Val Glu Leu Lys Arg Val Leu Tyr 
65                  70                  75                  80  


Asp Pro Phe Leu Pro Pro Leu Arg Leu Ser Thr Gly Gly Glu Lys Leu 
                85                  90                  95      


Arg Gly Thr Leu Tyr Asn Thr Gly Arg His Val Ser Phe Leu Pro Ala 
            100                 105                 110         


Pro Arg Pro Val Val Asn Val Ser Gly Gly Pro Leu Leu Tyr Ser His 
        115                 120                 125             


Arg Leu Ser Glu Leu Arg Leu Leu Phe Gly Ala Arg Asp Gly Ala Gly 
    130                 135                 140                 


Ser Glu His Gln Ile Asn His Gln Gly Phe Ser Ala Glu Val Gln Leu 
145                 150                 155                 160 


Ile His Phe Asn Gln Glu Leu Tyr Gly Asn Phe Ser Ala Ala Ser Arg 
                165                 170                 175     


Gly Pro Asn Gly Leu Ala Ile Leu Ser Leu Phe Val Asn Val Ala Ser 
            180                 185                 190         


Thr Ser Asn Pro Phe Leu Ser Arg Leu Leu Asn Arg Asp Thr Ile Thr 
        195                 200                 205             


Arg Ile Ser Tyr Lys Asn Asp Ala Tyr Phe Leu Gln Asp Leu Ser Leu 
    210                 215                 220                 


Glu Leu Leu Phe Pro Glu Ser Phe Gly Phe Ile Thr Tyr Gln Gly Ser 
225                 230                 235                 240 


Leu Ser Thr Pro Pro Cys Ser Glu Thr Val Thr Trp Ile Leu Ile Asp 
                245                 250                 255     


Arg Ala Leu Asn Ile Thr Ser Leu Gln Met His Ser Leu Arg Leu Leu 
            260                 265                 270         


Ser Gln Asn Pro Pro Ser Gln Ile Phe Gln Ser Leu Ser Gly Asn Ser 
        275                 280                 285             


Arg Pro Leu Gln Pro Leu Ala His Arg Ala Leu Arg Gly Asn Arg Asp 
    290                 295                 300                 


Pro Arg His Pro Glu Arg Arg Cys Arg Gly Pro Asn Tyr Arg Leu His 
305                 310                 315                 320 


Val Asp Gly Val Pro His Gly Arg 
                325             


<210>  1475
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA12__Homo_sapiens__NP_001209

<400>  1475

Met Pro Arg Arg Ser Leu His Ala Ala Ala Val Leu Leu Leu Val Ile 
1               5                   10                  15      


Leu Lys Glu Gln Pro Ser Ser Pro Ala Pro Val Asn Gly Ser Lys Trp 
            20                  25                  30          


Thr Tyr Phe Gly Pro Asp Gly Glu Asn Ser Trp Ser Lys Lys Tyr Pro 
        35                  40                  45              


Ser Cys Gly Gly Leu Leu Gln Ser Pro Ile Asp Leu His Ser Asp Ile 
    50                  55                  60                  


Leu Gln Tyr Asp Ala Ser Leu Thr Pro Leu Glu Phe Gln Gly Tyr Asn 
65                  70                  75                  80  


Leu Ser Ala Asn Lys Gln Phe Leu Leu Thr Asn Asn Gly His Ser Val 
                85                  90                  95      


Lys Leu Asn Leu Pro Ser Asp Met His Ile Gln Gly Leu Gln Ser Arg 
            100                 105                 110         


Tyr Ser Ala Thr Gln Leu His Leu His Trp Gly Asn Pro Asn Asp Pro 
        115                 120                 125             


His Gly Ser Glu His Thr Val Ser Gly Gln His Phe Ala Ala Glu Leu 
    130                 135                 140                 


His Ile Val His Tyr Asn Ser Asp Leu Tyr Pro Asp Ala Ser Thr Ala 
145                 150                 155                 160 


Ser Asn Lys Ser Glu Gly Leu Ala Val Leu Ala Val Leu Ile Glu Met 
                165                 170                 175     


Gly Ser Phe Asn Pro Ser Tyr Asp Lys Ile Phe Ser His Leu Gln His 
            180                 185                 190         


Val Lys Tyr Lys Gly Gln Glu Ala Phe Val Pro Gly Phe Asn Ile Glu 
        195                 200                 205             


Glu Leu Leu Pro Glu Arg Thr Ala Glu Tyr Tyr Arg Tyr Arg Gly Ser 
    210                 215                 220                 


Leu Thr Thr Pro Pro Cys Asn Pro Thr Val Leu Trp Thr Val Phe Arg 
225                 230                 235                 240 


Asn Pro Val Gln Ile Ser Gln Glu Gln Leu Leu Ala Leu Glu Thr Ala 
                245                 250                 255     


Leu Tyr Cys Thr His Met Asp Asp Pro Ser Pro Arg Glu Met Ile Asn 
            260                 265                 270         


Asn Phe Arg Gln Val Gln Lys Phe Asp Glu Arg Leu Val Tyr Thr Ser 
        275                 280                 285             


Phe Ser Gln Val Gln Val Cys Thr Ala Ala Gly Leu Ser Leu Gly Ile 
    290                 295                 300                 


Ile Leu Ser Leu Ala Leu Ala Gly Ile Leu Gly Ile Cys Ile Val Val 
305                 310                 315                 320 


Val Val Ser Ile Trp Leu Phe Arg Arg Lys Ser Ile Lys Lys Gly Asp 
                325                 330                 335     


Asn Lys Gly Val Ile Tyr Lys Pro Ala Thr Lys Met Glu Thr Glu Ala 
            340                 345                 350         


His Ala 
        


<210>  1476
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA13__Homo_sapiens__NP_940986

<400>  1476

Met Ser Arg Leu Ser Trp Gly Tyr Arg Glu His Asn Gly Pro Ile His 
1               5                   10                  15      


Trp Lys Glu Phe Phe Pro Ile Ala Asp Gly Asp Gln Gln Ser Pro Ile 
            20                  25                  30          


Glu Ile Lys Thr Lys Glu Val Lys Tyr Asp Ser Ser Leu Arg Pro Leu 
        35                  40                  45              


Ser Ile Lys Tyr Asp Pro Ser Ser Ala Lys Ile Ile Ser Asn Ser Gly 
    50                  55                  60                  


His Ser Phe Asn Val Asp Phe Asp Asp Thr Glu Asn Lys Ser Val Leu 
65                  70                  75                  80  


Arg Gly Gly Pro Leu Thr Gly Ser Tyr Arg Leu Arg Gln Val His Leu 
                85                  90                  95      


His Trp Gly Ser Ala Asp Asp His Gly Ser Glu His Ile Val Asp Gly 
            100                 105                 110         


Val Ser Tyr Ala Ala Glu Leu His Val Val His Trp Asn Ser Asp Lys 
        115                 120                 125             


Tyr Pro Ser Phe Val Glu Ala Ala His Glu Pro Asp Gly Leu Ala Val 
    130                 135                 140                 


Leu Gly Val Phe Leu Gln Ile Gly Glu Pro Asn Ser Gln Leu Gln Lys 
145                 150                 155                 160 


Ile Thr Asp Thr Leu Asp Ser Ile Lys Glu Lys Gly Lys Gln Thr Arg 
                165                 170                 175     


Phe Thr Asn Phe Asp Leu Leu Ser Leu Leu Pro Pro Ser Trp Asp Tyr 
            180                 185                 190         


Trp Thr Tyr Pro Gly Ser Leu Thr Val Pro Pro Leu Leu Glu Ser Val 
        195                 200                 205             


Thr Trp Ile Val Leu Lys Gln Pro Ile Asn Ile Ser Ser Gln Gln Leu 
    210                 215                 220                 


Ala Lys Phe Arg Ser Leu Leu Cys Thr Ala Glu Gly Glu Ala Ala Ala 
225                 230                 235                 240 


Phe Leu Val Ser Asn His Arg Pro Pro Gln Pro Leu Lys Gly Arg Lys 
                245                 250                 255     


Val Arg Ala Ser Phe His 
            260         


<210>  1477
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA1__Homo_sapiens__XP_011515886

<400>  1477

Met Ala Ser Pro Asp Trp Gly Tyr Asp Asp Lys Asn Gly Pro Glu Gln 
1               5                   10                  15      


Trp Ser Lys Leu Tyr Pro Ile Ala Asn Gly Asn Asn Gln Ser Pro Val 
            20                  25                  30          


Asp Ile Lys Thr Ser Glu Thr Lys His Asp Thr Ser Leu Lys Pro Ile 
        35                  40                  45              


Ser Val Ser Tyr Asn Pro Ala Thr Ala Lys Glu Ile Ile Asn Val Gly 
    50                  55                  60                  


His Ser Phe His Val Asn Phe Glu Asp Asn Asp Asn Arg Ser Val Leu 
65                  70                  75                  80  


Lys Gly Gly Pro Phe Ser Asp Ser Tyr Arg Leu Phe Gln Phe His Phe 
                85                  90                  95      


His Trp Gly Ser Thr Asn Glu His Gly Ser Glu His Thr Val Asp Gly 
            100                 105                 110         


Val Lys Tyr Ser Ala Glu Leu His Val Ala His Trp Asn Ser Ala Lys 
        115                 120                 125             


Tyr Ser Ser Leu Ala Glu Ala Ala Ser Lys Ala Asp Gly Leu Ala Val 
    130                 135                 140                 


Ile Gly Val Leu Met Lys Val Gly Glu Ala Asn Pro Lys Leu Gln Lys 
145                 150                 155                 160 


Val Leu Asp Ala Leu Gln Ala Ile Lys Thr Lys Gly Lys Arg Ala Pro 
                165                 170                 175     


Phe Thr Asn Phe Asp Pro Ser Thr Leu Leu Pro Ser Ser Leu Asp Phe 
            180                 185                 190         


Trp Thr Tyr Pro Gly Ser Leu Thr His Pro Pro Leu Tyr Glu Ser Val 
        195                 200                 205             


Thr Trp Ile Ile Cys Lys Glu Ser Ile Ser Val Ser Ser Glu Gln Leu 
    210                 215                 220                 


Ala Gln Phe Arg Ser Leu Leu Ser Asn Val Glu Gly Asp Asn Ala Val 
225                 230                 235                 240 


Pro Met Gln His Asn Asn Arg Pro Thr Gln Pro Leu Lys Gly Arg Thr 
                245                 250                 255     


Val Arg Ala Ser Phe 
            260     


<210>  1478
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA2__Homo_sapiens__NP_000058

<400>  1478

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  1479
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA3__Homo_sapiens__NP_005172

<400>  1479

Met Ala Lys Glu Trp Gly Tyr Ala Ser His Asn Gly Pro Asp His Trp 
1               5                   10                  15      


His Glu Leu Phe Pro Asn Ala Lys Gly Glu Asn Gln Ser Pro Val Glu 
            20                  25                  30          


Leu His Thr Lys Asp Ile Arg His Asp Pro Ser Leu Gln Pro Trp Ser 
        35                  40                  45              


Val Ser Tyr Asp Gly Gly Ser Ala Lys Thr Ile Leu Asn Asn Gly Lys 
    50                  55                  60                  


Thr Cys Arg Val Val Phe Asp Asp Thr Tyr Asp Arg Ser Met Leu Arg 
65                  70                  75                  80  


Gly Gly Pro Leu Pro Gly Pro Tyr Arg Leu Arg Gln Phe His Leu His 
                85                  90                  95      


Trp Gly Ser Ser Asp Asp His Gly Ser Glu His Thr Val Asp Gly Val 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Pro Lys Tyr Asn 
        115                 120                 125             


Thr Phe Lys Glu Ala Leu Lys Gln Arg Asp Gly Ile Ala Val Ile Gly 
    130                 135                 140                 


Ile Phe Leu Lys Ile Gly His Glu Asn Gly Glu Phe Gln Ile Phe Leu 
145                 150                 155                 160 


Asp Ala Leu Asp Lys Ile Lys Thr Lys Gly Lys Glu Ala Pro Phe Thr 
                165                 170                 175     


Lys Phe Asp Pro Ser Cys Leu Phe Pro Ala Cys Arg Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Gln Gly Ser Phe Thr Thr Pro Pro Cys Glu Glu Cys Ile Val Trp 
        195                 200                 205             


Leu Leu Leu Lys Glu Pro Met Thr Val Ser Ser Asp Gln Met Ala Lys 
    210                 215                 220                 


Leu Arg Ser Leu Leu Ser Ser Ala Glu Asn Glu Pro Pro Val Pro Leu 
225                 230                 235                 240 


Val Ser Asn Trp Arg Pro Pro Gln Pro Ile Asn Asn Arg Val Val Arg 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  1480
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA4__Homo_sapiens__NP_000708

<400>  1480

Met Arg Met Leu Leu Ala Leu Leu Ala Leu Ser Ala Ala Arg Pro Ser 
1               5                   10                  15      


Ala Ser Ala Glu Ser His Trp Cys Tyr Glu Val Gln Ala Glu Ser Ser 
            20                  25                  30          


Asn Tyr Pro Cys Leu Val Pro Val Lys Trp Gly Gly Asn Cys Gln Lys 
        35                  40                  45              


Asp Arg Gln Ser Pro Ile Asn Ile Val Thr Thr Lys Ala Lys Val Asp 
    50                  55                  60                  


Lys Lys Leu Gly Arg Phe Phe Phe Ser Gly Tyr Asp Lys Lys Gln Thr 
65                  70                  75                  80  


Trp Thr Val Gln Asn Asn Gly His Ser Val Met Met Leu Leu Glu Asn 
                85                  90                  95      


Lys Ala Ser Ile Ser Gly Gly Gly Leu Pro Ala Pro Tyr Gln Ala Lys 
            100                 105                 110         


Gln Leu His Leu His Trp Ser Asp Leu Pro Tyr Lys Gly Ser Glu His 
        115                 120                 125             


Ser Leu Asp Gly Glu His Phe Ala Met Glu Met His Ile Val His Glu 
    130                 135                 140                 


Lys Glu Lys Gly Thr Ser Arg Asn Val Lys Glu Ala Gln Asp Pro Glu 
145                 150                 155                 160 


Asp Glu Ile Ala Val Leu Ala Phe Leu Val Glu Ala Gly Thr Gln Val 
                165                 170                 175     


Asn Glu Gly Phe Gln Pro Leu Val Glu Ala Leu Ser Asn Ile Pro Lys 
            180                 185                 190         


Pro Glu Met Ser Thr Thr Met Ala Glu Ser Ser Leu Leu Asp Leu Leu 
        195                 200                 205             


Pro Lys Glu Glu Lys Leu Arg His Tyr Phe Arg Tyr Leu Gly Ser Leu 
    210                 215                 220                 


Thr Thr Pro Thr Cys Asp Glu Lys Val Val Trp Thr Val Phe Arg Glu 
225                 230                 235                 240 


Pro Ile Gln Leu His Arg Glu Gln Ile Leu Ala Phe Ser Gln Lys Leu 
                245                 250                 255     


Tyr Tyr Asp Lys Glu Gln Thr Val Ser Met Lys Asp Asn Val Arg Pro 
            260                 265                 270         


Leu Gln Gln Leu Gly Gln Arg Thr Val Ile Lys Ser Gly Ala Pro Gly 
        275                 280                 285             


Arg Pro Leu Pro Trp Ala Leu Pro Ala Leu Leu Gly Pro Met Leu Ala 
    290                 295                 300                 


Cys Leu Leu Ala Gly Phe Leu Arg 
305                 310         


<210>  1481
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA5A__Homo_sapiens__NP_001730

<400>  1481

Met Leu Gly Arg Asn Thr Trp Lys Thr Ser Ala Phe Ser Phe Leu Val 
1               5                   10                  15      


Glu Gln Met Trp Ala Pro Leu Trp Ser Arg Ser Met Arg Pro Gly Arg 
            20                  25                  30          


Trp Cys Ser Gln Arg Ser Cys Ala Trp Gln Thr Ser Asn Asn Thr Leu 
        35                  40                  45              


His Pro Leu Trp Thr Val Pro Val Ser Val Pro Gly Gly Thr Arg Gln 
    50                  55                  60                  


Ser Pro Ile Asn Ile Gln Trp Arg Asp Ser Val Tyr Asp Pro Gln Leu 
65                  70                  75                  80  


Lys Pro Leu Arg Val Ser Tyr Glu Ala Ala Ser Cys Leu Tyr Ile Trp 
                85                  90                  95      


Asn Thr Gly Tyr Leu Phe Gln Val Glu Phe Asp Asp Ala Thr Glu Ala 
            100                 105                 110         


Ser Gly Ile Ser Gly Gly Pro Leu Glu Asn His Tyr Arg Leu Lys Gln 
        115                 120                 125             


Phe His Phe His Trp Gly Ala Val Asn Glu Gly Gly Ser Glu His Thr 
    130                 135                 140                 


Val Asp Gly His Ala Tyr Pro Ala Glu Leu His Leu Val His Trp Asn 
145                 150                 155                 160 


Ser Val Lys Tyr Gln Asn Tyr Lys Glu Ala Val Val Gly Glu Asn Gly 
                165                 170                 175     


Leu Ala Val Ile Gly Val Phe Leu Lys Leu Gly Ala His His Gln Thr 
            180                 185                 190         


Leu Gln Arg Leu Val Asp Ile Leu Pro Glu Ile Lys His Lys Asp Ala 
        195                 200                 205             


Arg Ala Ala Met Arg Pro Phe Asp Pro Ser Thr Leu Leu Pro Thr Cys 
    210                 215                 220                 


Trp Asp Tyr Trp Thr Tyr Ala Gly Ser Leu Thr Thr Pro Pro Leu Thr 
225                 230                 235                 240 


Glu Ser Val Thr Trp Ile Ile Gln Lys Glu Pro Val Glu Val Ala Pro 
                245                 250                 255     


Ser Gln Leu Ser Ala Phe Arg Thr Leu Leu Phe Ser Ala Leu Gly Glu 
            260                 265                 270         


Glu Glu Lys Met Met Val Asn Asn Tyr Arg Pro Leu Gln Pro Leu Met 
        275                 280                 285             


Asn Arg Lys Val Trp Ala Ser Phe Gln Ala Thr Asn Glu Gly Thr Arg 
    290                 295                 300                 


Ser 
305 


<210>  1482
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA6__Homo_sapiens__XP_011540385

<400>  1482

Met Cys Ser Thr Met Arg Ala Leu Val Leu Leu Leu Ser Leu Phe Leu 
1               5                   10                  15      


Leu Gly Gly Gln Ala Gln His Val Ser Asp Trp Thr Tyr Ser Glu Gly 
            20                  25                  30          


Ala Leu Asp Glu Ala His Trp Pro Gln His Tyr Pro Ala Cys Gly Gly 
        35                  40                  45              


Gln Arg Gln Ser Pro Ile Asn Leu Gln Arg Thr Lys Val Arg Tyr Asn 
    50                  55                  60                  


Pro Ser Leu Lys Gly Leu Asn Met Thr Gly Tyr Glu Thr Gln Ala Gly 
65                  70                  75                  80  


Glu Phe Pro Met Val Asn Asn Gly His Thr Val Gln Ile Ser Leu Pro 
                85                  90                  95      


Ser Thr Met Arg Met Thr Val Ala Asp Gly Thr Val Tyr Ile Ala Gln 
            100                 105                 110         


Gln Met His Phe His Trp Gly Gly Ala Ser Ser Glu Ile Ser Gly Ser 
        115                 120                 125             


Glu His Thr Val Asp Gly Ile Arg His Val Ile Glu Ile His Ile Val 
    130                 135                 140                 


His Tyr Asn Ser Lys Tyr Lys Ser Tyr Asp Ile Ala Gln Asp Ala Pro 
145                 150                 155                 160 


Asp Gly Leu Ala Val Leu Ala Ala Phe Val Glu Val Lys Asn Tyr Pro 
                165                 170                 175     


Glu Asn Thr Tyr Tyr Ser Asn Phe Ile Ser His Leu Ala Asn Ile Lys 
            180                 185                 190         


Tyr Pro Gly Gln Arg Thr Thr Leu Thr Gly Leu Asp Val Gln Asp Met 
        195                 200                 205             


Leu Pro Arg Asn Leu Gln His Tyr Tyr Thr Tyr His Gly Ser Leu Thr 
    210                 215                 220                 


Thr Pro Pro Cys Thr Glu Asn Val His Trp Phe Val Leu Ala Asp Phe 
225                 230                 235                 240 


Val Lys Leu Ser Arg Thr Gln Val Trp Lys Leu Glu Asn Ser Leu Leu 
                245                 250                 255     


Asp His Arg Asn Lys Thr Ile His Asn Asp Tyr Arg Arg Thr Gln Pro 
            260                 265                 270         


Leu Asn His Arg Val Val Glu Ser Asn Phe Pro Asn Gln Glu Asn Cys 
        275                 280                 285             


Ile Pro Ala Gly Leu Ile 
    290                 


<210>  1483
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CA8__Homo_sapiens__NP_004047

<400>  1483

Met Ala Asp Leu Ser Phe Ile Glu Asp Thr Val Ala Phe Pro Glu Lys 
1               5                   10                  15      


Glu Glu Asp Glu Glu Glu Glu Glu Glu Gly Val Glu Trp Gly Tyr Glu 
            20                  25                  30          


Glu Gly Val Glu Trp Gly Leu Val Phe Pro Asp Ala Asn Gly Glu Tyr 
        35                  40                  45              


Gln Ser Pro Ile Asn Leu Asn Ser Arg Glu Ala Arg Tyr Asp Pro Ser 
    50                  55                  60                  


Leu Leu Asp Val Arg Leu Ser Pro Asn Tyr Val Val Cys Arg Asp Cys 
65                  70                  75                  80  


Glu Val Thr Asn Asp Gly His Thr Ile Gln Val Ile Leu Lys Ser Lys 
                85                  90                  95      


Ser Val Leu Ser Gly Gly Pro Leu Pro Gln Gly His Glu Phe Glu Leu 
            100                 105                 110         


Tyr Glu Val Arg Phe His Trp Gly Arg Glu Asn Gln Arg Gly Ser Glu 
        115                 120                 125             


His Thr Val Asn Phe Lys Ala Phe Pro Met Glu Leu His Leu Ile His 
    130                 135                 140                 


Trp Asn Ser Thr Leu Phe Gly Ser Ile Asp Glu Ala Val Gly Lys Pro 
145                 150                 155                 160 


His Gly Ile Ala Ile Ile Ala Leu Phe Val Gln Ile Gly Lys Glu His 
                165                 170                 175     


Val Gly Leu Lys Ala Val Thr Glu Ile Leu Gln Asp Ile Gln Tyr Lys 
            180                 185                 190         


Gly Lys Ser Lys Thr Ile Pro Cys Phe Asn Pro Asn Thr Leu Leu Pro 
        195                 200                 205             


Asp Pro Leu Leu Arg Asp Tyr Trp Val Tyr Glu Gly Ser Leu Thr Ile 
    210                 215                 220                 


Pro Pro Cys Ser Glu Gly Val Thr Trp Ile Leu Phe Arg Tyr Pro Leu 
225                 230                 235                 240 


Thr Ile Ser Gln Leu Gln Ile Glu Glu Phe Arg Arg Leu Arg Thr His 
                245                 250                 255     


Val Lys Gly Ala Glu Leu Val Glu Gly Cys Asp Gly Ile Leu Gly Asp 
            260                 265                 270         


Asn Phe Arg Pro Thr Gln Pro Leu Ser Asp Arg Val Ile Arg Ala Ala 
        275                 280                 285             


Phe Gln 
    290 


<210>  1484
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAB39__Homo_sapiens__NP_001124322

<400>  1484

Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala Asp Ile Val 
1               5                   10                  15      


Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln Asp Ile Ser 
            20                  25                  30          


Asp Lys Lys Ala Glu Lys Ala Thr Glu Glu Val Ser Lys Asn Leu Val 
        35                  40                  45              


Ala Met Lys Glu Ile Leu Tyr Gly Thr Asn Glu Lys Glu Pro Gln Thr 
    50                  55                  60                  


Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Thr Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys 
                85                  90                  95      


Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Thr 
            100                 105                 110         


Arg Thr Pro Thr Val Glu Tyr Ile Cys Thr Gln Gln Asn Ile Leu Phe 
        115                 120                 125             


Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu Asn Cys Gly 
    130                 135                 140                 


Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile 
145                 150                 155                 160 


Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu Met Ser 
                165                 170                 175     


Thr Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys Asp Leu Leu 
            180                 185                 190         


Thr Arg His Lys Leu Leu Ser Ala Glu Phe Leu Glu Gln His Tyr Asp 
        195                 200                 205             


Arg Phe Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu Asn Tyr Val 
    210                 215                 220                 


Thr Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp Arg 
225                 230                 235                 240 


His Asn Phe Thr Ile Met Thr Lys Tyr Ile Ser Lys Pro Glu Asn Leu 
                245                 250                 255     


Lys Leu Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn Ile Gln Phe 
            260                 265                 270         


Glu Ala Phe His Val Phe Lys Val Phe Val Ala Asn Pro Asn Lys Thr 
        275                 280                 285             


Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile Glu 
    290                 295                 300                 


Phe Leu Ser Lys Phe Gln Asn Asp Arg Thr Glu Asp Glu Gln Phe Asn 
305                 310                 315                 320 


Asp Glu Lys Thr Tyr Leu Val Lys Gln Ile Arg Asp Leu Lys Arg Pro 
                325                 330                 335     


Ala Gln Gln Glu Ala 
            340     


<210>  1485
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAB39L__Homo_sapiens__NP_001274268

<400>  1485

Met Lys Lys Met Pro Leu Phe Ser Lys Ser His Lys Asn Pro Ala Glu 
1               5                   10                  15      


Ile Val Lys Ile Leu Lys Asp Asn Leu Ala Ile Leu Glu Lys Gln Asp 
            20                  25                  30          


Lys Lys Thr Asp Lys Ala Ser Glu Glu Val Ser Lys Ser Leu Gln Ala 
        35                  40                  45              


Met Lys Glu Ile Leu Cys Gly Thr Asn Glu Lys Glu Pro Pro Thr Glu 
    50                  55                  60                  


Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Ser Ser Gly Leu Leu Val 
65                  70                  75                  80  


Thr Leu Ile Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys Asp 
                85                  90                  95      


Val Thr Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Thr Arg 
            100                 105                 110         


Ser Pro Thr Val Glu Tyr Ile Ser Ala His Pro His Ile Leu Phe Met 
        115                 120                 125             


Leu Leu Lys Gly Tyr Glu Ala Pro Gln Ile Ala Leu Arg Cys Gly Ile 
    130                 135                 140                 


Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile Leu 
145                 150                 155                 160 


Phe Ser Asn Gln Phe Arg Asp Phe Phe Lys Tyr Val Glu Leu Ser Thr 
                165                 170                 175     


Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys Asp Leu Leu Thr 
            180                 185                 190         


Arg His Lys Val Leu Val Ala Asp Phe Leu Glu Gln Asn Tyr Asp Thr 
        195                 200                 205             


Ile Phe Glu Asp Tyr Glu Lys Leu Leu Gln Ser Glu Asn Tyr Val Thr 
    210                 215                 220                 


Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Ile Leu Asp Arg His 
225                 230                 235                 240 


Asn Phe Ala Ile Met Thr Lys Tyr Ile Ser Lys Pro Glu Asn Leu Lys 
                245                 250                 255     


Leu Met Met Asn Leu Leu Arg Asp Lys Ser Pro Asn Ile Gln Phe Glu 
            260                 265                 270         


Ala Phe His Val Phe Lys Val Phe Val Ala Ser Pro His Lys Thr Gln 
        275                 280                 285             


Pro Ile Val Glu Ile Leu Leu Lys Asn Gln Pro Lys Leu Ile Glu Phe 
    290                 295                 300                 


Leu Ser Ser Phe Gln Lys Glu Arg Thr Asp Asp Glu Gln Phe Ala Asp 
305                 310                 315                 320 


Glu Lys Asn Tyr Leu Ile Lys Gln Ile Arg Asp Leu Lys Lys Thr Ala 
                325                 330                 335     


Pro 
    


<210>  1486
<211>  2220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CABIN1__Homo_sapiens__NP_036427

<400>  1486

Met Ile Arg Ile Ala Ala Leu Asn Ala Ser Ser Thr Ile Glu Asp Asp 
1               5                   10                  15      


His Glu Gly Ser Phe Lys Ser His Lys Thr Gln Thr Lys Glu Ala Gln 
            20                  25                  30          


Glu Ala Glu Ala Phe Ala Leu Tyr His Lys Ala Leu Asp Leu Gln Lys 
        35                  40                  45              


His Asp Arg Phe Glu Glu Ser Ala Lys Ala Tyr His Glu Leu Leu Glu 
    50                  55                  60                  


Ala Ser Leu Leu Arg Glu Ala Val Ser Ser Gly Asp Glu Lys Glu Gly 
65                  70                  75                  80  


Leu Lys His Pro Gly Leu Ile Leu Lys Tyr Ser Thr Tyr Lys Asn Leu 
                85                  90                  95      


Ala Gln Leu Ala Ala Gln Arg Glu Asp Leu Glu Thr Ala Met Glu Phe 
            100                 105                 110         


Tyr Leu Glu Ala Val Met Leu Asp Ser Thr Asp Val Asn Leu Trp Tyr 
        115                 120                 125             


Lys Ile Gly His Val Ala Leu Arg Leu Ile Arg Ile Pro Leu Ala Arg 
    130                 135                 140                 


His Ala Phe Glu Glu Gly Leu Arg Cys Asn Pro Asp His Trp Pro Cys 
145                 150                 155                 160 


Leu Asp Asn Leu Ile Thr Val Leu Tyr Thr Leu Ser Asp Tyr Thr Thr 
                165                 170                 175     


Cys Leu Tyr Phe Ile Cys Lys Ala Leu Glu Lys Asp Cys Arg Tyr Ser 
            180                 185                 190         


Lys Gly Leu Val Leu Lys Glu Lys Ile Phe Glu Glu Gln Pro Cys Leu 
        195                 200                 205             


Arg Lys Asp Ser Leu Arg Met Phe Leu Lys Cys Asp Met Ser Ile His 
    210                 215                 220                 


Asp Val Ser Val Ser Ala Ala Glu Thr Gln Ala Ile Val Asp Glu Ala 
225                 230                 235                 240 


Leu Gly Leu Arg Lys Lys Arg Gln Ala Leu Ile Val Arg Glu Lys Glu 
                245                 250                 255     


Pro Asp Leu Lys Leu Val Gln Pro Ile Pro Phe Phe Thr Trp Lys Cys 
            260                 265                 270         


Leu Gly Glu Ser Leu Leu Ala Met Tyr Asn His Leu Thr Thr Cys Glu 
        275                 280                 285             


Pro Pro Arg Pro Ser Leu Gly Lys Arg Ile Asp Leu Ser Asp Tyr Gln 
    290                 295                 300                 


Asp Pro Ser Gln Pro Leu Glu Ser Ser Met Val Val Thr Pro Val Asn 
305                 310                 315                 320 


Val Ile Gln Pro Ser Thr Val Ser Thr Asn Pro Ala Val Ala Val Ala 
                325                 330                 335     


Glu Pro Val Val Ser Tyr Thr Ser Val Ala Thr Thr Ser Phe Pro Leu 
            340                 345                 350         


His Ser Pro Gly Leu Leu Glu Thr Gly Ala Pro Val Gly Asp Ile Ser 
        355                 360                 365             


Gly Gly Asp Lys Ser Lys Lys Gly Val Lys Arg Lys Lys Ile Ser Glu 
    370                 375                 380                 


Glu Ser Gly Glu Thr Ala Lys Arg Arg Ser Ala Arg Val Arg Asn Thr 
385                 390                 395                 400 


Lys Cys Lys Lys Glu Glu Lys Val Asp Phe Gln Glu Leu Leu Met Lys 
                405                 410                 415     


Phe Leu Pro Ser Arg Leu Arg Lys Leu Asp Pro Glu Glu Glu Asp Asp 
            420                 425                 430         


Ser Phe Asn Asn Tyr Glu Val Gln Ser Glu Ala Lys Leu Glu Ser Phe 
        435                 440                 445             


Pro Ser Ile Gly Pro Gln Arg Leu Ser Phe Asp Ser Ala Thr Phe Met 
    450                 455                 460                 


Glu Ser Glu Lys Gln Asp Val His Glu Phe Leu Leu Glu Asn Leu Thr 
465                 470                 475                 480 


Asn Gly Gly Ile Leu Glu Leu Met Met Arg Tyr Leu Lys Ala Met Gly 
                485                 490                 495     


His Lys Phe Leu Val Arg Trp Pro Pro Gly Leu Ala Glu Val Val Leu 
            500                 505                 510         


Ser Val Tyr His Ser Trp Arg Arg His Ser Thr Ser Leu Pro Asn Pro 
        515                 520                 525             


Leu Leu Arg Asp Cys Ser Asn Lys His Ile Lys Asp Met Met Leu Met 
    530                 535                 540                 


Ser Leu Ser Cys Met Glu Leu Gln Leu Asp Gln Trp Leu Leu Thr Lys 
545                 550                 555                 560 


Gly Arg Ser Ser Ala Val Ser Pro Arg Asn Cys Pro Ala Gly Met Val 
                565                 570                 575     


Asn Gly Arg Phe Gly Pro Asp Phe Pro Gly Thr His Cys Leu Gly Asp 
            580                 585                 590         


Leu Leu Gln Leu Ser Phe Ala Ser Ser Gln Arg Asp Leu Phe Glu Asp 
        595                 600                 605             


Gly Trp Leu Glu Phe Val Val Arg Val Tyr Trp Leu Lys Ala Arg Phe 
    610                 615                 620                 


Leu Ala Leu Gln Gly Asp Met Glu Gln Ala Leu Glu Asn Tyr Asp Ile 
625                 630                 635                 640 


Cys Thr Glu Met Leu Gln Ser Ser Thr Ala Ile Gln Val Glu Ala Gly 
                645                 650                 655     


Ala Glu Arg Arg Asp Ile Val Ile Arg Leu Pro Asn Leu His Asn Asp 
            660                 665                 670         


Ser Val Val Ser Leu Glu Glu Ile Asp Lys Asn Leu Lys Ser Leu Glu 
        675                 680                 685             


Arg Cys Gln Ser Leu Glu Glu Ile Gln Arg Leu Tyr Glu Ala Gly Asp 
    690                 695                 700                 


Tyr Lys Ala Val Val His Leu Leu Arg Pro Thr Leu Cys Thr Ser Gly 
705                 710                 715                 720 


Phe Asp Arg Ala Lys His Leu Glu Phe Met Thr Ser Ile Pro Glu Arg 
                725                 730                 735     


Pro Ala Gln Leu Leu Leu Leu Gln Asp Ser Leu Leu Arg Leu Lys Asp 
            740                 745                 750         


Tyr Arg Gln Cys Phe Glu Cys Ser Asp Val Ala Leu Asn Glu Ala Val 
        755                 760                 765             


Gln Gln Met Val Asn Ser Gly Glu Ala Ala Ala Lys Glu Glu Trp Val 
    770                 775                 780                 


Ala Thr Val Thr Gln Leu Leu Met Gly Ile Glu Gln Ala Leu Ser Ala 
785                 790                 795                 800 


Asp Ser Ser Gly Ser Ile Leu Lys Val Ser Ser Ser Thr Thr Gly Leu 
                805                 810                 815     


Val Arg Leu Thr Asn Asn Leu Ile Gln Val Ile Asp Cys Ser Met Ala 
            820                 825                 830         


Val Gln Glu Glu Ala Lys Glu Pro His Val Ser Ser Val Leu Pro Trp 
        835                 840                 845             


Ile Ile Leu His Arg Ile Ile Trp Gln Glu Glu Asp Thr Phe His Ser 
    850                 855                 860                 


Leu Cys His Gln Gln Gln Leu Gln Asn Pro Ala Glu Glu Gly Met Ser 
865                 870                 875                 880 


Glu Thr Pro Met Leu Pro Ser Ser Leu Met Leu Leu Asn Thr Ala His 
                885                 890                 895     


Glu Tyr Leu Gly Arg Arg Ser Trp Cys Cys Asn Ser Asp Gly Ala Leu 
            900                 905                 910         


Leu Arg Phe Tyr Val Arg Val Leu Gln Lys Glu Leu Ala Ala Ser Thr 
        915                 920                 925             


Ser Glu Asp Thr His Pro Tyr Lys Glu Glu Leu Glu Thr Ala Leu Glu 
    930                 935                 940                 


Gln Cys Phe Tyr Cys Leu Tyr Ser Phe Pro Ser Lys Lys Ser Lys Ala 
945                 950                 955                 960 


Arg Tyr Leu Glu Glu His Ser Ala Gln Gln Val Asp Leu Ile Trp Glu 
                965                 970                 975     


Asp Ala Leu Phe Met Phe Glu Tyr Phe Lys Pro Lys Thr Leu Pro Glu 
            980                 985                 990         


Phe Asp Ser Tyr Lys Thr Ser Thr  Val Ser Ala Asp Leu  Ala Asn Leu 
        995                 1000                 1005             


Leu Lys  Arg Ile Ala Thr Ile  Val Pro Arg Thr Glu  Arg Pro Ala 
    1010                 1015                 1020             


Leu Ser  Leu Asp Lys Val Ser  Ala Tyr Ile Glu Gly  Thr Ser Thr 
    1025                 1030                 1035             


Glu Val  Pro Cys Leu Pro Glu  Gly Ala Asp Pro Ser  Pro Pro Val 
    1040                 1045                 1050             


Val Asn  Glu Leu Tyr Tyr Leu  Leu Ala Asp Tyr His  Phe Lys Asn 
    1055                 1060                 1065             


Lys Glu  Gln Ser Lys Ala Ile  Lys Phe Tyr Met His  Asp Ile Cys 
    1070                 1075                 1080             


Ile Cys  Pro Asn Arg Phe Asp  Ser Trp Ala Gly Met  Ala Leu Ala 
    1085                 1090                 1095             


Arg Ala  Ser Arg Ile Gln Asp  Lys Leu Asn Ser Asn  Glu Leu Lys 
    1100                 1105                 1110             


Ser Asp  Gly Pro Ile Trp Lys  His Ala Thr Pro Val  Leu Asn Cys 
    1115                 1120                 1125             


Phe Arg  Arg Ala Leu Glu Ile  Asp Ser Ser Asn Leu  Ser Leu Trp 
    1130                 1135                 1140             


Ile Glu  Tyr Gly Thr Met Ser  Tyr Ala Leu His Ser  Phe Ala Ser 
    1145                 1150                 1155             


Arg Gln  Leu Lys Gln Trp Arg  Gly Glu Leu Pro Pro  Glu Leu Val 
    1160                 1165                 1170             


Gln Gln  Met Glu Gly Arg Arg  Asp Ser Met Leu Glu  Thr Ala Lys 
    1175                 1180                 1185             


His Cys  Phe Thr Ser Ala Ala  Arg Cys Glu Gly Asp  Gly Asp Glu 
    1190                 1195                 1200             


Glu Glu  Trp Leu Ile His Tyr  Met Leu Gly Lys Val  Ala Glu Lys 
    1205                 1210                 1215             


Gln Gln  Gln Pro Pro Thr Val  Tyr Leu Leu His Tyr  Arg Gln Ala 
    1220                 1225                 1230             


Gly His  Tyr Leu His Glu Glu  Ala Ala Arg Tyr Pro  Lys Lys Ile 
    1235                 1240                 1245             


His Tyr  His Asn Pro Pro Glu  Leu Ala Met Glu Ala  Leu Glu Val 
    1250                 1255                 1260             


Tyr Phe  Arg Leu His Ala Ser  Ile Leu Lys Leu Leu  Gly Lys Pro 
    1265                 1270                 1275             


Asp Ser  Gly Val Gly Ala Glu  Val Leu Val Asn Phe  Met Lys Glu 
    1280                 1285                 1290             


Ala Ala  Glu Gly Pro Phe Ala  Arg Gly Glu Glu Lys  Asn Thr Pro 
    1295                 1300                 1305             


Lys Ala  Ser Glu Lys Glu Lys  Ala Cys Leu Val Asp  Glu Asp Ser 
    1310                 1315                 1320             


His Ser  Ser Ala Gly Thr Leu  Pro Gly Pro Gly Ala  Ser Leu Pro 
    1325                 1330                 1335             


Ser Ser  Ser Gly Pro Gly Leu  Thr Ser Pro Pro Tyr  Thr Ala Thr 
    1340                 1345                 1350             


Pro Ile  Asp His Asp Tyr Val  Lys Cys Lys Lys Pro  His Gln Gln 
    1355                 1360                 1365             


Ala Thr  Pro Asp Asp Arg Ser  Gln Asp Ser Thr Ala  Val Ala Leu 
    1370                 1375                 1380             


Ser Asp  Ser Ser Ser Thr Gln  Asp Phe Phe Asn Glu  Pro Thr Ser 
    1385                 1390                 1395             


Leu Leu  Glu Gly Ser Arg Lys  Ser Tyr Thr Glu Lys  Arg Leu Pro 
    1400                 1405                 1410             


Ile Leu  Ser Ser Gln Ala Gly  Ala Thr Gly Lys Asp  Leu Gln Gly 
    1415                 1420                 1425             


Ala Thr  Glu Glu Arg Gly Lys  Asn Glu Glu Ser Leu  Glu Ser Thr 
    1430                 1435                 1440             


Glu Gly  Phe Arg Ala Ala Glu  Gln Gly Val Gln Lys  Pro Ala Ala 
    1445                 1450                 1455             


Glu Thr  Pro Ala Ser Ala Cys  Ile Pro Gly Lys Pro  Ser Ala Ser 
    1460                 1465                 1470             


Thr Pro  Thr Leu Trp Asp Gly  Lys Lys Arg Gly Asp  Leu Pro Gly 
    1475                 1480                 1485             


Glu Pro  Val Ala Phe Pro Gln  Gly Leu Pro Ala Gly  Ala Glu Glu 
    1490                 1495                 1500             


Gln Arg  Gln Phe Leu Thr Glu  Gln Cys Ile Ala Ser  Phe Arg Leu 
    1505                 1510                 1515             


Cys Leu  Ser Arg Phe Pro Gln  His Tyr Lys Ser Leu  Tyr Arg Leu 
    1520                 1525                 1530             


Ala Phe  Leu Tyr Thr Tyr Ser  Lys Thr His Arg Asn  Leu Gln Trp 
    1535                 1540                 1545             


Ala Arg  Asp Val Leu Leu Gly  Ser Ser Ile Pro Trp  Gln Gln Leu 
    1550                 1555                 1560             


Gln His  Met Pro Ala Gln Gly  Leu Phe Cys Glu Arg  Asn Lys Thr 
    1565                 1570                 1575             


Asn Phe  Phe Asn Gly Ile Trp  Arg Ile Pro Val Asp  Glu Ile Asp 
    1580                 1585                 1590             


Arg Pro  Gly Ser Phe Ala Trp  His Met Asn Arg Ser  Ile Val Leu 
    1595                 1600                 1605             


Leu Leu  Lys Val Leu Ala Gln  Leu Arg Asp His Ser  Thr Leu Leu 
    1610                 1615                 1620             


Lys Val  Ser Ser Met Leu Gln  Arg Thr Pro Asp Gln  Gly Lys Lys 
    1625                 1630                 1635             


Tyr Leu  Arg Asp Ala Asp Arg  Gln Val Leu Ala Gln  Arg Ala Phe 
    1640                 1645                 1650             


Ile Leu  Thr Val Lys Val Leu  Glu Asp Thr Leu Ser  Glu Leu Ala 
    1655                 1660                 1665             


Glu Gly  Ser Glu Arg Pro Gly  Pro Lys Val Cys Gly  Leu Pro Gly 
    1670                 1675                 1680             


Ala Arg  Met Thr Thr Asp Val  Ser His Lys Ala Ser  Pro Glu Asp 
    1685                 1690                 1695             


Gly Gln  Glu Gly Leu Pro Gln  Pro Lys Lys Pro Pro  Leu Ala Asp 
    1700                 1705                 1710             


Gly Ser  Gly Pro Gly Pro Glu  Pro Gly Gly Lys Val  Gly Leu Leu 
    1715                 1720                 1725             


Asn His  Arg Pro Val Ala Met  Asp Ala Gly Asp Ser  Ala Asp Gln 
    1730                 1735                 1740             


Ser Gly  Glu Arg Lys Asp Lys  Glu Ser Pro Arg Ala  Gly Pro Thr 
    1745                 1750                 1755             


Glu Pro  Met Asp Thr Ser Glu  Ala Thr Val Cys His  Ser Asp Leu 
    1760                 1765                 1770             


Glu Arg  Thr Pro Pro Leu Leu  Pro Gly Arg Pro Ala  Arg Asp Arg 
    1775                 1780                 1785             


Gly Pro  Glu Ser Arg Pro Thr  Glu Leu Ser Leu Glu  Glu Leu Ser 
    1790                 1795                 1800             


Ile Ser  Ala Arg Gln Gln Pro  Thr Pro Leu Thr Pro  Ala Gln Pro 
    1805                 1810                 1815             


Ala Pro  Ala Pro Ala Pro Ala  Thr Thr Thr Gly Thr  Arg Ala Gly 
    1820                 1825                 1830             


Gly His  Pro Glu Glu Pro Leu  Ser Arg Leu Ser Arg  Lys Arg Lys 
    1835                 1840                 1845             


Leu Leu  Glu Asp Thr Glu Ser  Gly Lys Thr Leu Leu  Leu Asp Ala 
    1850                 1855                 1860             


Tyr Arg  Val Trp Gln Gln Gly  Gln Lys Gly Val Ala  Tyr Asp Leu 
    1865                 1870                 1875             


Gly Arg  Val Glu Arg Ile Met  Ser Glu Thr Tyr Met  Leu Ile Lys 
    1880                 1885                 1890             


Gln Val  Asp Glu Glu Ala Ala  Leu Glu Gln Ala Val  Lys Phe Cys 
    1895                 1900                 1905             


Gln Val  His Leu Gly Ala Ala  Ala Gln Arg Gln Ala  Ser Gly Asp 
    1910                 1915                 1920             


Thr Pro  Thr Thr Pro Lys His  Pro Lys Asp Ser Arg  Glu Asn Phe 
    1925                 1930                 1935             


Phe Pro  Val Thr Val Val Pro  Thr Ala Pro Asp Pro  Val Pro Ala 
    1940                 1945                 1950             


Asp Ser  Val Gln Arg Pro Ser  Asp Ala His Thr Lys  Pro Arg Pro 
    1955                 1960                 1965             


Ala Leu  Ala Ala Ala Thr Thr  Ile Ile Thr Cys Pro  Pro Ser Ala 
    1970                 1975                 1980             


Ser Ala  Ser Thr Leu Asp Gln  Ser Lys Asp Pro Gly  Pro Pro Arg 
    1985                 1990                 1995             


Pro His  Arg Pro Glu Ala Thr  Pro Ser Met Ala Ser  Leu Gly Pro 
    2000                 2005                 2010             


Glu Gly  Glu Glu Leu Ala Arg  Val Ala Glu Gly Thr  Ser Phe Pro 
    2015                 2020                 2025             


Pro Gln  Glu Pro Arg His Ser  Pro Gln Val Lys Met  Ala Pro Thr 
    2030                 2035                 2040             


Ser Ser  Pro Ala Glu Pro His  Cys Trp Pro Ala Glu  Ala Ala Leu 
    2045                 2050                 2055             


Gly Thr  Gly Ala Glu Pro Thr  Cys Ser Gln Glu Gly  Lys Leu Arg 
    2060                 2065                 2070             


Pro Glu  Pro Arg Arg Asp Gly  Glu Ala Gln Glu Ala  Ala Ser Glu 
    2075                 2080                 2085             


Thr Gln  Pro Leu Ser Ser Pro  Pro Thr Ala Ala Ser  Ser Lys Ala 
    2090                 2095                 2100             


Pro Ser  Ser Gly Ser Ala Gln  Pro Pro Glu Gly His  Pro Gly Lys 
    2105                 2110                 2115             


Pro Glu  Pro Ser Arg Ala Lys  Ser Arg Pro Leu Pro  Asn Met Pro 
    2120                 2125                 2130             


Lys Leu  Val Ile Pro Ser Ala  Ala Thr Lys Phe Pro  Pro Glu Ile 
    2135                 2140                 2145             


Thr Val  Thr Pro Pro Thr Pro  Thr Leu Leu Ser Pro  Lys Gly Ser 
    2150                 2155                 2160             


Ile Ser  Glu Glu Thr Lys Gln  Lys Leu Lys Ser Ala  Ile Leu Ser 
    2165                 2170                 2175             


Ala Gln  Ser Ala Ala Asn Val  Arg Lys Glu Ser Leu  Cys Gln Pro 
    2180                 2185                 2190             


Ala Leu  Glu Val Leu Glu Thr  Ser Ser Gln Glu Ser  Ser Leu Glu 
    2195                 2200                 2205             


Ser Glu  Thr Asp Glu Asp Asp  Asp Tyr Met Asp Ile  
    2210                 2215                 2220 


<210>  1487
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CABLES1__Homo_sapiens__NP_001094089

<400>  1487

Met Ala Ala Ala Ala Ala Ala Ala Thr Thr Ala Ala Cys Ser Ser Gly 
1               5                   10                  15      


Ser Ala Gly Thr Asp Ala Ala Gly Ala Ser Gly Leu Gln Gln Pro Pro 
            20                  25                  30          


Pro Gln Pro Gln Pro Gln Pro Ala Ala Ala Ala Pro Ala Gln Pro Pro 
        35                  40                  45              


Pro Glu Pro Pro Arg Lys Pro Arg Met Asp Pro Arg Arg Arg Gln Ala 
    50                  55                  60                  


Ala Leu Ser Phe Leu Thr Asn Ile Ser Leu Asp Gly Arg Leu Pro Pro 
65                  70                  75                  80  


Gln Asp Ala Glu Trp Gly Gly Gly Glu Glu Gly Gly Ala Ala Lys Pro 
                85                  90                  95      


Gly Ala Gly Gly Ala Cys Gly Ala Arg Thr Arg Phe Ser Leu Leu Ala 
            100                 105                 110         


Ala Ala Glu Arg Gly Gly Cys Ile Ala Leu Ala Ala Pro Gly Thr Pro 
        115                 120                 125             


Ala Ala Gly Leu Ala Ala Gly Ser Gly Pro Cys Leu Pro Gln Pro Ser 
    130                 135                 140                 


Ser Leu Pro Pro Leu Ile Pro Gly Gly His Ala Thr Val Ser Gly Pro 
145                 150                 155                 160 


Gly Val Ala Arg Gly Phe Ala Ser Pro Leu Gly Ala Gly Arg Ala Ser 
                165                 170                 175     


Gly Glu Gln Trp Gln Pro Pro Arg Pro Ala Pro Leu Ala Ala Cys Ala 
            180                 185                 190         


Gln Leu Gln Leu Leu Asp Gly Ser Gly Ala Ala Gly Gln Glu Glu Leu 
        195                 200                 205             


Glu Glu Asp Asp Ala Phe Ile Ser Val Gln Val Pro Ala Ala Ala Phe 
    210                 215                 220                 


Leu Gly Ser Gly Thr Pro Gly Ser Gly Ser Gly Ser Arg Gly Arg Leu 
225                 230                 235                 240 


Asn Ser Phe Thr Gln Gly Ile Leu Pro Ile Ala Phe Ser Arg Pro Thr 
                245                 250                 255     


Ser Gln Asn Tyr Cys Ser Leu Glu Gln Pro Gly Gln Gly Gly Ser Thr 
            260                 265                 270         


Ser Ala Phe Glu Gln Leu Gln Arg Ser Arg Arg Arg Leu Ile Ser Gln 
        275                 280                 285             


Arg Ser Ser Leu Glu Thr Leu Glu Asp Ile Glu Glu Asn Ala Pro Leu 
    290                 295                 300                 


Arg Arg Cys Arg Thr Leu Ser Gly Ser Pro Arg Pro Lys Asn Phe Lys 
305                 310                 315                 320 


Lys Ile His Phe Ile Lys Asn Met Arg Gln His Asp Thr Arg Asn Gly 
                325                 330                 335     


Arg Ile Val Leu Ile Ser Gly Arg Arg Ser Phe Cys Ser Ile Phe Ser 
            340                 345                 350         


Val Leu Pro Tyr Arg Asp Ser Thr Gln Val Gly Asp Leu Lys Leu Asp 
        355                 360                 365             


Gly Gly Arg Gln Ser Thr Gly Ala Val Ser Leu Lys Glu Ile Ile Gly 
    370                 375                 380                 


Leu Glu Gly Val Glu Leu Gly Ala Asp Gly Lys Thr Val Ser Tyr Thr 
385                 390                 395                 400 


Gln Phe Leu Leu Pro Thr Asn Ala Phe Gly Ala Arg Arg Asn Thr Ile 
                405                 410                 415     


Asp Ser Thr Ser Ser Phe Ser Gln Phe Arg Asn Leu Ser His Arg Ser 
            420                 425                 430         


Leu Ser Ile Gly Arg Ala Ser Gly Thr Gln Gly Ser Leu Asp Thr Gly 
        435                 440                 445             


Ser Asp Leu Gly Asp Phe Met Asp Tyr Asp Pro Asn Leu Leu Asp Asp 
    450                 455                 460                 


Pro Gln Trp Pro Cys Gly Lys His Lys Arg Val Leu Ile Phe Pro Ser 
465                 470                 475                 480 


Tyr Met Thr Thr Val Ile Asp Tyr Val Lys Pro Ser Asp Leu Lys Lys 
                485                 490                 495     


Asp Met Asn Glu Thr Phe Lys Glu Lys Phe Pro His Ile Lys Leu Thr 
            500                 505                 510         


Leu Ser Lys Ile Arg Ser Leu Lys Arg Glu Met Arg Lys Leu Ala Gln 
        515                 520                 525             


Glu Asp Cys Gly Leu Glu Glu Pro Thr Val Ala Met Ala Phe Val Tyr 
    530                 535                 540                 


Phe Glu Lys Leu Ala Leu Lys Gly Lys Leu Asn Lys Gln Asn Arg Lys 
545                 550                 555                 560 


Leu Cys Ala Gly Ala Cys Val Leu Leu Ala Ala Lys Ile Gly Ser Asp 
                565                 570                 575     


Leu Lys Lys His Glu Val Lys His Leu Ile Asp Lys Leu Glu Glu Lys 
            580                 585                 590         


Phe Arg Leu Asn Arg Arg Glu Leu Ile Ala Phe Glu Phe Pro Val Leu 
        595                 600                 605             


Val Ala Leu Glu Phe Ala Leu His Leu Pro Glu His Glu Val Met Pro 
    610                 615                 620                 


His Tyr Arg Arg Leu Val Gln Ser Ser 
625                 630             


<210>  1488
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CABP2__Homo_sapiens__NP_057450

<400>  1488

Met Gly Asn Cys Ala Lys Arg Pro Trp Arg Arg Gly Pro Lys Asp Pro 
1               5                   10                  15      


Leu Gln Trp Leu Gly Ser Pro Pro Arg Gly Ser Cys Pro Ser Pro Ser 
            20                  25                  30          


Ser Ser Pro Lys Glu Gln Gly Asp Pro Ala Pro Gly Val Gln Gly Tyr 
        35                  40                  45              


Ser Val Leu Asn Ser Leu Val Gly Pro Ala Cys Ile Phe Leu Arg Pro 
    50                  55                  60                  


Ser Ile Ala Ala Thr Gln Leu Asp Arg Glu Leu Arg Pro Glu Glu Ile 
65                  70                  75                  80  


Glu Glu Leu Gln Val Ala Phe Gln Glu Phe Asp Arg Asp Arg Asp Gly 
                85                  90                  95      


Tyr Ile Gly Cys Arg Glu Leu Gly Ala Cys Met Arg Thr Leu Gly Tyr 
            100                 105                 110         


Met Pro Thr Glu Met Glu Leu Ile Glu Ile Ser Gln Gln Ile Ser Gly 
        115                 120                 125             


Gly Lys Val Asp Phe Glu Asp Phe Val Glu Leu Met Gly Pro Lys Leu 
    130                 135                 140                 


Leu Ala Glu Thr Ala Asp Met Ile Gly Val Arg Glu Leu Arg Asp Ala 
145                 150                 155                 160 


Phe Arg Glu Phe Asp Thr Asn Gly Asp Gly Arg Ile Ser Val Gly Glu 
                165                 170                 175     


Leu Arg Ala Ala Leu Lys Ala Leu Leu Gly Glu Arg Leu Ser Gln Arg 
            180                 185                 190         


Glu Val Asp Glu Ile Leu Gln Asp Val Asp Leu Asn Gly Asp Gly Leu 
        195                 200                 205             


Val Asp Phe Glu Glu Phe Val Arg Met Met Ser Arg 
    210                 215                 220 


<210>  1489
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CABP4__Homo_sapiens__NP_001287824

<400>  1489

Met Thr Glu Pro Trp Leu Ala Leu Gly Thr Ser Trp Thr Leu Pro Leu 
1               5                   10                  15      


Gln Asp Arg Glu Leu Gly Pro Glu Glu Leu Asp Glu Leu Gln Ala Ala 
            20                  25                  30          


Phe Glu Glu Phe Asp Thr Asp Arg Asp Gly Tyr Ile Ser His Arg Glu 
        35                  40                  45              


Leu Gly Asp Cys Met Arg Thr Leu Gly Tyr Met Pro Thr Glu Met Glu 
    50                  55                  60                  


Leu Leu Glu Val Ser Gln His Ile Lys Met Arg Met Gly Gly Arg Val 
65                  70                  75                  80  


Asp Phe Glu Glu Phe Val Glu Leu Ile Gly Pro Lys Leu Arg Glu Glu 
                85                  90                  95      


Thr Ala His Met Leu Gly Val Arg Glu Leu Arg Ile Ala Phe Arg Glu 
            100                 105                 110         


Phe Asp Arg Asp Arg Asp Gly Arg Ile Thr Val Ala Glu Leu Arg Glu 
        115                 120                 125             


Ala Val Pro Ala Leu Leu Gly Glu Pro Leu Ala Gly Pro Glu Leu Asp 
    130                 135                 140                 


Glu Met Leu Arg Glu Val Asp Leu Asn Gly Asp Gly Thr Val Asp Phe 
145                 150                 155                 160 


Asp Glu Phe Val Met Met Leu Ser Arg His 
                165                 170 


<210>  1490
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CABS1__Homo_sapiens__NP_149113

<400>  1490

Met Ala Glu Asp Gly Leu Pro Lys Ile Tyr Ser His Pro Pro Thr Glu 
1               5                   10                  15      


Ser Ser Lys Thr Pro Thr Ala Ala Thr Ile Phe Phe Gly Ala Asp Asn 
            20                  25                  30          


Ala Ile Pro Lys Ser Glu Thr Thr Ile Thr Ser Glu Gly Asp His Val 
        35                  40                  45              


Thr Ser Val Asn Glu Tyr Met Leu Glu Ser Asp Phe Ser Thr Thr Thr 
    50                  55                  60                  


Asp Asn Lys Leu Thr Ala Lys Lys Glu Lys Leu Lys Ser Glu Asp Asp 
65                  70                  75                  80  


Met Gly Thr Asp Phe Ile Lys Ser Thr Thr His Leu Gln Lys Glu Ile 
                85                  90                  95      


Thr Ser Leu Thr Gly Thr Thr Asn Ser Ile Thr Arg Asp Ser Ile Thr 
            100                 105                 110         


Glu His Phe Met Pro Val Lys Ile Gly Asn Ile Ser Ser Pro Val Thr 
        115                 120                 125             


Thr Val Ser Leu Ile Asp Phe Ser Thr Asp Ile Ala Lys Glu Asp Ile 
    130                 135                 140                 


Leu Leu Ala Thr Ile Asp Thr Gly Asp Ala Glu Ile Ser Ile Thr Ser 
145                 150                 155                 160 


Glu Val Ser Gly Thr Leu Lys Asp Ser Ser Ala Gly Val Ala Asp Ala 
                165                 170                 175     


Pro Ala Phe Pro Arg Lys Lys Asp Glu Ala Asp Met Ser Asn Tyr Asn 
            180                 185                 190         


Ser Ser Ile Lys Ser Asn Val Pro Ala Asp Glu Ala Val Gln Val Thr 
        195                 200                 205             


Asp Ser Thr Ile Pro Glu Ala Glu Ile Pro Pro Ala Pro Glu Glu Ser 
    210                 215                 220                 


Phe Thr Thr Ile Pro Asp Ile Thr Ala Leu Glu Glu Glu Lys Ile Thr 
225                 230                 235                 240 


Glu Ile Asp Leu Ser Val Leu Glu Asp Asp Thr Ser Ala Val Ala Thr 
                245                 250                 255     


Leu Thr Asp Ser Asp Glu Lys Phe Ile Thr Val Phe Glu Leu Thr Thr 
            260                 265                 270         


Ser Ala Glu Lys Asp Lys Asp Lys Arg Glu Asp Thr Leu Leu Thr Asp 
        275                 280                 285             


Glu Glu Thr Thr Glu Gly Ala Ser Ile Trp Met Glu Arg Asp Thr Ala 
    290                 295                 300                 


Asn Glu Ala Glu Thr His Ser Val Leu Leu Thr Ala Val Glu Ser Arg 
305                 310                 315                 320 


Tyr Asp Phe Val Val Pro Ala Ser Ile Ala Thr Asn Leu Val Glu Glu 
                325                 330                 335     


Ser Ser Thr Glu Glu Asp Leu Ser Glu Thr Asp Asn Thr Glu Thr Val 
            340                 345                 350         


Pro Lys Ile Thr Glu Pro Phe Ser Gly Thr Thr Ser Val Leu Asp Thr 
        355                 360                 365             


Pro Asp Tyr Lys Glu Asp Thr Ser Thr Thr Glu Thr Asp Ile Phe Glu 
    370                 375                 380                 


Leu Leu Lys Glu Glu Pro Asp Glu Phe Met Ile 
385                 390                 395 


<210>  1491
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CABYR__Homo_sapiens__NP_036321

<400>  1491

Met Ile Ser Ser Lys Pro Arg Leu Val Val Pro Tyr Gly Leu Lys Thr 
1               5                   10                  15      


Leu Leu Glu Gly Ile Ser Arg Ala Val Leu Lys Thr Asn Pro Ser Asn 
            20                  25                  30          


Ile Asn Gln Phe Ala Ala Ala Tyr Phe Gln Glu Leu Thr Met Tyr Arg 
        35                  40                  45              


Gly Asn Thr Thr Met Asp Ile Lys Asp Leu Val Lys Gln Phe His Gln 
    50                  55                  60                  


Ile Lys Val Glu Lys Trp Ser Glu Gly Thr Thr Pro Gln Lys Lys Leu 
65                  70                  75                  80  


Glu Cys Leu Lys Glu Pro Gly Lys Thr Ser Val Glu Ser Lys Val Pro 
                85                  90                  95      


Thr Gln Met Glu Lys Ser Thr Asp Thr Asp Glu Asp Asn Val Thr Arg 
            100                 105                 110         


Thr Glu Tyr Ser Asp Lys Thr Thr Gln Phe Pro Ser Val Tyr Ala Val 
        115                 120                 125             


Pro Gly Thr Glu Gln Thr Glu Ala Val Gly Gly Leu Ser Ser Lys Pro 
    130                 135                 140                 


Ala Thr Pro Lys Thr Thr Thr Pro Pro Ser Ser Pro Pro Pro Thr Ala 
145                 150                 155                 160 


Val Ser Pro Glu Phe Ala Tyr Val Pro Ala Asp Pro Ala Gln Leu Ala 
                165                 170                 175     


Ala Gln Met Leu Gly Lys Val Ser Ser Ile His Ser Asp Gln Ser Asp 
            180                 185                 190         


Val Leu Met Val Asp Val Ala Thr Ser Met Pro Val Val Ile Lys Glu 
        195                 200                 205             


Val Pro Ser Ser Glu Ala Ala Glu Asp Val Met Val Ala Ala Pro Leu 
    210                 215                 220                 


Val Cys Ser Gly Lys Val Leu Glu Val Gln Val Val Asn Gln Thr Ser 
225                 230                 235                 240 


Val His Val Asp Leu Gly Ser Gln Pro Lys Glu Asn Glu Ala Glu Pro 
                245                 250                 255     


Ser Thr Ala Ser Ser Val Pro Leu Gln Asp Glu Gln Glu Pro Pro Ala 
            260                 265                 270         


Tyr Asp Gln Ala Pro Glu Val Thr Leu Gln Ala Asp Ile Glu Val Met 
        275                 280                 285             


Ser Thr Val His Ile Ser Ser Val Tyr Asn Asp Val Pro Val Thr Glu 
    290                 295                 300                 


Gly Val Val Tyr Ile Glu Gln Leu Pro Glu Gln Ile Val Ile Pro Phe 
305                 310                 315                 320 


Thr Asp Gln Val Ala Cys Leu Lys Glu Asn Glu Gln Ser Lys Glu Asn 
                325                 330                 335     


Glu Gln Ser Pro Arg Val Ser Pro Lys Ser Val Val Glu Lys Thr Thr 
            340                 345                 350         


Ser Gly Met Ser Lys Lys Ser Val Glu Ser Val Lys Leu Ala Gln Leu 
        355                 360                 365             


Glu Glu Asn Ala Lys Tyr Ser Ser Val Tyr Met Glu Ala Glu Ala Thr 
    370                 375                 380                 


Ala Leu Leu Ser Asp Thr Ser Leu Lys Gly Gln Pro Glu Val Pro Ala 
385                 390                 395                 400 


Gln Leu Leu Asp Ala Glu Gly Ala Ile Lys Ile Gly Ser Glu Lys Ser 
                405                 410                 415     


Leu His Leu Glu Val Glu Ile Thr Ser Ile Val Ser Asp Asn Thr Gly 
            420                 425                 430         


Gln Glu Glu Ser Gly Glu Asn Ser Val Pro Gln Glu Met Glu Gly Lys 
        435                 440                 445             


Pro Val Leu Ser Gly Glu Ala Ala Glu Ala Val His Ser Gly Thr Ser 
    450                 455                 460                 


Val Lys Ser Ser Ser Gly Pro Phe Pro Pro Ala Pro Glu Gly Leu Thr 
465                 470                 475                 480 


Ala Pro Glu Ile Glu Pro Glu Gly Glu Ser Thr Ala Glu 
                485                 490             


<210>  1492
<211>  2261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1A__Homo_sapiens__NP_001120693

<400>  1492

Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln 
                725                 730                 735     


Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu 
            740                 745                 750         


Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln 
        755                 760                 765             


Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys 
    770                 775                 780                 


Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro 
785                 790                 795                 800 


Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met 
                805                 810                 815     


Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg 
            820                 825                 830         


Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln 
        835                 840                 845             


Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg 
    850                 855                 860                 


Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala 
865                 870                 875                 880 


Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly 
                885                 890                 895     


Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu 
            900                 905                 910         


Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp 
        915                 920                 925             


Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg 
    930                 935                 940                 


Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg 
945                 950                 955                 960 


Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg 
                965                 970                 975     


Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly 
            980                 985                 990         


Glu Gly Glu Gly Pro Asp Gly Gly  Glu Arg Arg Arg Arg  His Arg His 
        995                 1000                 1005             


Gly Ala  Pro Ala Thr Tyr Glu  Gly Asp Ala Arg Arg  Glu Asp Lys 
    1010                 1015                 1020             


Glu Arg  Arg His Arg Arg Arg  Lys Glu Asn Gln Gly  Ser Gly Val 
    1025                 1030                 1035             


Pro Val  Ser Gly Pro Asn Leu  Ser Thr Thr Arg Pro  Ile Gln Gln 
    1040                 1045                 1050             


Asp Leu  Gly Arg Gln Asp Pro  Pro Leu Ala Glu Asp  Ile Asp Asn 
    1055                 1060                 1065             


Met Lys  Asn Asn Lys Leu Ala  Thr Ala Glu Ser Ala  Ala Pro His 
    1070                 1075                 1080             


Gly Ser  Leu Gly His Ala Gly  Leu Pro Gln Ser Pro  Ala Lys Met 
    1085                 1090                 1095             


Gly Asn  Ser Thr Asp Pro Gly  Pro Met Leu Ala Ile  Pro Ala Met 
    1100                 1105                 1110             


Ala Thr  Asn Pro Gln Asn Ala  Ala Ser Arg Arg Thr  Pro Asn Asn 
    1115                 1120                 1125             


Pro Gly  Asn Pro Ser Asn Pro  Gly Pro Pro Lys Thr  Pro Glu Asn 
    1130                 1135                 1140             


Ser Leu  Ile Val Thr Asn Pro  Ser Gly Thr Gln Thr  Asn Ser Ala 
    1145                 1150                 1155             


Lys Thr  Ala Arg Lys Pro Asp  His Thr Thr Val Asp  Ile Pro Pro 
    1160                 1165                 1170             


Ala Cys  Pro Pro Pro Leu Asn  His Thr Val Val Gln  Val Asn Lys 
    1175                 1180                 1185             


Asn Ala  Asn Pro Asp Pro Leu  Pro Lys Lys Glu Glu  Glu Lys Lys 
    1190                 1195                 1200             


Glu Glu  Glu Glu Asp Asp Arg  Gly Glu Asp Gly Pro  Lys Pro Met 
    1205                 1210                 1215             


Pro Pro  Tyr Ser Ser Met Phe  Ile Leu Ser Thr Thr  Asn Pro Leu 
    1220                 1225                 1230             


Arg Arg  Leu Cys His Tyr Ile  Leu Asn Leu Arg Tyr  Phe Glu Met 
    1235                 1240                 1245             


Cys Ile  Leu Met Val Ile Ala  Met Ser Ser Ile Ala  Leu Ala Ala 
    1250                 1255                 1260             


Glu Asp  Pro Val Gln Pro Asn  Ala Pro Arg Asn Asn  Val Leu Arg 
    1265                 1270                 1275             


Tyr Phe  Asp Tyr Val Phe Thr  Gly Val Phe Thr Phe  Glu Met Val 
    1280                 1285                 1290             


Ile Lys  Met Ile Asp Leu Gly  Leu Val Leu His Gln  Gly Ala Tyr 
    1295                 1300                 1305             


Phe Arg  Asp Leu Trp Asn Ile  Leu Asp Phe Ile Val  Val Ser Gly 
    1310                 1315                 1320             


Ala Leu  Val Ala Phe Ala Phe  Thr Gly Asn Ser Lys  Gly Lys Asp 
    1325                 1330                 1335             


Ile Asn  Thr Ile Lys Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro 
    1340                 1345                 1350             


Leu Lys  Thr Ile Lys Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp 
    1355                 1360                 1365             


Cys Val  Val Asn Ser Leu Lys  Asn Val Phe Asn Ile  Leu Ile Val 
    1370                 1375                 1380             


Tyr Met  Leu Phe Met Phe Ile  Phe Ala Val Val Ala  Val Gln Leu 
    1385                 1390                 1395             


Phe Lys  Gly Lys Phe Phe His  Cys Thr Asp Glu Ser  Lys Glu Phe 
    1400                 1405                 1410             


Glu Lys  Asp Cys Arg Gly Lys  Tyr Leu Leu Tyr Glu  Lys Asn Glu 
    1415                 1420                 1425             


Val Lys  Ala Arg Asp Arg Glu  Trp Lys Lys Tyr Glu  Phe His Tyr 
    1430                 1435                 1440             


Asp Asn  Val Leu Trp Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr 
    1445                 1450                 1455             


Gly Glu  Gly Trp Pro Gln Val  Leu Lys His Ser Val  Asp Ala Thr 
    1460                 1465                 1470             


Phe Glu  Asn Gln Gly Pro Ser  Pro Gly Tyr Arg Met  Glu Met Ser 
    1475                 1480                 1485             


Ile Phe  Tyr Val Val Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val 
    1490                 1495                 1500             


Asn Ile  Phe Val Ala Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly 
    1505                 1510                 1515             


Asp Lys  Met Met Glu Glu Tyr  Ser Leu Glu Lys Asn  Glu Arg Ala 
    1520                 1525                 1530             


Cys Ile  Asp Phe Ala Ile Ser  Ala Lys Pro Leu Thr  Arg His Met 
    1535                 1540                 1545             


Pro Gln  Asn Lys Gln Ser Phe  Gln Tyr Arg Met Trp  Gln Phe Val 
    1550                 1555                 1560             


Val Ser  Pro Pro Phe Glu Tyr  Thr Ile Met Ala Met  Ile Ala Leu 
    1565                 1570                 1575             


Asn Thr  Ile Val Leu Met Met  Lys Phe Tyr Gly Ala  Ser Val Ala 
    1580                 1585                 1590             


Tyr Glu  Asn Ala Leu Arg Val  Phe Asn Ile Val Phe  Thr Ser Leu 
    1595                 1600                 1605             


Phe Ser  Leu Glu Cys Val Leu  Lys Val Met Ala Phe  Gly Ile Leu 
    1610                 1615                 1620             


Asn Tyr  Phe Arg Asp Ala Trp  Asn Ile Phe Asp Phe  Val Thr Val 
    1625                 1630                 1635             


Leu Gly  Ser Ile Thr Asp Ile  Leu Val Thr Glu Phe  Gly Asn Asn 
    1640                 1645                 1650             


Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe Arg Ala  Ala Arg Leu 
    1655                 1660                 1665             


Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile Arg Ile  Leu Leu Trp 
    1670                 1675                 1680             


Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro Tyr Val  Cys Leu Leu 
    1685                 1690                 1695             


Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile Ile Gly  Met Gln Val 
    1700                 1705                 1710             


Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp Glu Asp  Ser Asp Glu 
    1715                 1720                 1725             


Asp Glu  Phe Gln Ile Thr Glu  His Asn Asn Phe Arg  Thr Phe Phe 
    1730                 1735                 1740             


Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala Thr Gly  Glu Ala Trp 
    1745                 1750                 1755             


His Asn  Ile Met Leu Ser Cys  Leu Ser Gly Lys Pro  Cys Asp Lys 
    1760                 1765                 1770             


Asn Ser  Gly Ile Leu Thr Arg  Glu Cys Gly Asn Glu  Phe Ala Tyr 
    1775                 1780                 1785             


Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys Ser Phe  Leu Met Leu 
    1790                 1795                 1800             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Glu  Tyr Leu Thr 
    1805                 1810                 1815             


Arg Asp  Ser Ser Ile Leu Gly  Pro His His Leu Asp  Glu Tyr Val 
    1820                 1825                 1830             


Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala Cys Gly  Arg Ile His 
    1835                 1840                 1845             


Tyr Lys  Asp Met Tyr Ser Leu  Leu Arg Val Ile Ser  Pro Pro Leu 
    1850                 1855                 1860             


Gly Leu  Gly Lys Lys Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1865                 1870                 1875             


Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp Asn Thr  Val His Phe 
    1880                 1885                 1890             


Asn Ser  Thr Leu Met Ala Leu  Ile Arg Thr Ala Leu  Asp Ile Lys 
    1895                 1900                 1905             


Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln Met Asp  Ala Glu Leu 
    1910                 1915                 1920             


Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn Leu Ser  Gln Lys Thr 
    1925                 1930                 1935             


Leu Asp  Leu Leu Val Thr Pro  His Lys Ser Thr Asp  Leu Thr Val 
    1940                 1945                 1950             


Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met Glu Tyr  Tyr Arg Gln 
    1955                 1960                 1965             


Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg Glu Glu  Gln Asp Arg 
    1970                 1975                 1980             


Thr Pro  Leu Met Phe Gln Arg  Met Glu Pro Pro Ser  Pro Thr Gln 
    1985                 1990                 1995             


Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro Ser Thr  Gln Leu Asp 
    2000                 2005                 2010             


Pro Gly  Gly Ala Leu Met Ala  His Glu Ser Gly Leu  Lys Glu Ser 
    2015                 2020                 2025             


Pro Ser  Trp Val Thr Gln Arg  Ala Gln Glu Met Phe  Gln Lys Thr 
    2030                 2035                 2040             


Gly Thr  Trp Ser Pro Glu Gln  Gly Pro Pro Thr Asp  Met Pro Asn 
    2045                 2050                 2055             


Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met Arg Glu  Met Gly Arg 
    2060                 2065                 2070             


Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu Pro Met  Glu Gly Gln 
    2075                 2080                 2085             


Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro Ala Glu  Asn Gln Arg 
    2090                 2095                 2100             


Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu Ser Thr  Ile Ser Asp 
    2105                 2110                 2115             


Thr Ser  Pro Met Lys Arg Ser  Ala Ser Val Leu Gly  Pro Lys Ala 
    2120                 2125                 2130             


Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg Val Pro  Pro Glu Glu 
    2135                 2140                 2145             


Asn Gln  Arg His His Gln Arg  Arg Arg Asp Arg Ser  His Arg Ala 
    2150                 2155                 2160             


Ser Glu  Arg Ser Leu Gly Arg  Tyr Thr Asp Val Asp  Thr Gly Leu 
    2165                 2170                 2175             


Gly Thr  Asp Leu Ser Met Thr  Thr Gln Ser Gly Asp  Leu Pro Ser 
    2180                 2185                 2190             


Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro Lys Asp  Arg Lys His 
    2195                 2200                 2205             


Arg Gln  His His His His His  His His His His His  Pro Pro Pro 
    2210                 2215                 2220             


Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg Pro Asp  His Gly Arg 
    2225                 2230                 2235             


Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg Ser Pro  Ser Glu Gly 
    2240                 2245                 2250             


Arg Glu  His Met Ala His Arg  Gln 
    2255                 2260     


<210>  1493
<211>  2339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1B__Homo_sapiens__NP_000709

<400>  1493

Met Val Arg Phe Gly Asp Glu Leu Gly Gly Arg Tyr Gly Gly Pro Gly 
1               5                   10                  15      


Gly Gly Glu Arg Ala Arg Gly Gly Gly Ala Gly Gly Ala Gly Gly Pro 
            20                  25                  30          


Gly Pro Gly Gly Leu Gln Pro Gly Gln Arg Val Leu Tyr Lys Gln Ser 
        35                  40                  45              


Ile Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro Ile Pro Val 
    50                  55                  60                  


Lys Gln Asn Cys Phe Thr Val Asn Arg Ser Leu Phe Val Phe Ser Glu 
65                  70                  75                  80  


Asp Asn Val Val Arg Lys Tyr Ala Lys Arg Ile Thr Glu Trp Pro Pro 
                85                  90                  95      


Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys Ile Val Leu 
            100                 105                 110         


Ala Leu Glu Gln His Leu Pro Asp Gly Asp Lys Thr Pro Met Ser Glu 
        115                 120                 125             


Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu 
    130                 135                 140                 


Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Val Phe His Lys Gly Ser 
145                 150                 155                 160 


Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val Val Leu Thr 
                165                 170                 175     


Gly Ile Leu Ala Thr Ala Gly Thr Asp Phe Asp Leu Arg Thr Leu Arg 
            180                 185                 190         


Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser 
        195                 200                 205             


Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu 
    210                 215                 220                 


Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile 
225                 230                 235                 240 


Gly Leu Glu Phe Tyr Met Gly Lys Phe His Lys Ala Cys Phe Pro Asn 
                245                 250                 255     


Ser Thr Asp Ala Glu Pro Val Gly Asp Phe Pro Cys Gly Lys Glu Ala 
            260                 265                 270         


Pro Ala Arg Leu Cys Glu Gly Asp Thr Glu Cys Arg Glu Tyr Trp Pro 
        275                 280                 285             


Gly Pro Asn Phe Gly Ile Thr Asn Phe Asp Asn Ile Leu Phe Ala Ile 
    290                 295                 300                 


Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Ile Leu 
305                 310                 315                 320 


Tyr Asn Thr Asn Asp Ala Ala Gly Asn Thr Trp Asn Trp Leu Tyr Phe 
                325                 330                 335     


Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu Asn Leu Val Leu 
            340                 345                 350         


Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn 
        355                 360                 365             


Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu 
    370                 375                 380                 


Leu Asn Gly Tyr Leu Glu Trp Ile Phe Lys Ala Glu Glu Val Met Leu 
385                 390                 395                 400 


Ala Glu Glu Asp Arg Asn Ala Glu Glu Lys Ser Pro Leu Asp Val Leu 
                405                 410                 415     


Lys Arg Ala Ala Thr Lys Lys Ser Arg Asn Asp Leu Ile His Ala Glu 
            420                 425                 430         


Glu Gly Glu Asp Arg Phe Ala Asp Leu Cys Ala Val Gly Ser Pro Phe 
        435                 440                 445             


Ala Arg Ala Ser Leu Lys Ser Gly Lys Thr Glu Ser Ser Ser Tyr Phe 
    450                 455                 460                 


Arg Arg Lys Glu Lys Met Phe Arg Phe Phe Ile Arg Arg Met Val Lys 
465                 470                 475                 480 


Ala Gln Ser Phe Tyr Trp Val Val Leu Cys Val Val Ala Leu Asn Thr 
                485                 490                 495     


Leu Cys Val Ala Met Val His Tyr Asn Gln Pro Arg Arg Leu Thr Thr 
            500                 505                 510         


Thr Leu Tyr Phe Ala Glu Phe Val Phe Leu Gly Leu Phe Leu Thr Glu 
        515                 520                 525             


Met Ser Leu Lys Met Tyr Gly Leu Gly Pro Arg Ser Tyr Phe Arg Ser 
    530                 535                 540                 


Ser Phe Asn Cys Phe Asp Phe Gly Val Ile Val Gly Ser Val Phe Glu 
545                 550                 555                 560 


Val Val Trp Ala Ala Ile Lys Pro Gly Ser Ser Phe Gly Ile Ser Val 
                565                 570                 575     


Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val Thr Lys Tyr Trp 
            580                 585                 590         


Ser Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn Ser Met Lys Ser 
        595                 600                 605             


Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile Val Val Phe Ala 
    610                 615                 620                 


Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn Phe Gln Asp Glu 
625                 630                 635                 640 


Thr Pro Thr Thr Asn Phe Asp Thr Phe Pro Ala Ala Ile Leu Thr Val 
                645                 650                 655     


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr His Gly 
            660                 665                 670         


Ile Glu Ser Gln Gly Gly Val Ser Lys Gly Met Phe Ser Ser Phe Tyr 
        675                 680                 685             


Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe 
    690                 695                 700                 


Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys 
705                 710                 715                 720 


Asp Glu Glu Glu Met Glu Glu Ala Ala Asn Gln Lys Leu Ala Leu Gln 
                725                 730                 735     


Lys Ala Lys Glu Val Ala Glu Val Ser Pro Met Ser Ala Ala Asn Ile 
            740                 745                 750         


Ser Ile Ala Ala Arg Gln Gln Asn Ser Ala Lys Ala Arg Ser Val Trp 
        755                 760                 765             


Glu Gln Arg Ala Ser Gln Leu Arg Leu Gln Asn Leu Arg Ala Ser Cys 
    770                 775                 780                 


Glu Ala Leu Tyr Ser Glu Met Asp Pro Glu Glu Arg Leu Arg Phe Ala 
785                 790                 795                 800 


Thr Thr Arg His Leu Arg Pro Asp Met Lys Thr His Leu Asp Arg Pro 
                805                 810                 815     


Leu Val Val Glu Leu Gly Arg Asp Gly Ala Arg Gly Pro Val Gly Gly 
            820                 825                 830         


Lys Ala Arg Pro Glu Ala Ala Glu Ala Pro Glu Gly Val Asp Pro Pro 
        835                 840                 845             


Arg Arg His His Arg His Arg Asp Lys Asp Lys Thr Pro Ala Ala Gly 
    850                 855                 860                 


Asp Gln Asp Arg Ala Glu Ala Pro Lys Ala Glu Ser Gly Glu Pro Gly 
865                 870                 875                 880 


Ala Arg Glu Glu Arg Pro Arg Pro His Arg Ser His Ser Lys Glu Ala 
                885                 890                 895     


Ala Gly Pro Pro Glu Ala Arg Ser Glu Arg Gly Arg Gly Pro Gly Pro 
            900                 905                 910         


Glu Gly Gly Arg Arg His His Arg Arg Gly Ser Pro Glu Glu Ala Ala 
        915                 920                 925             


Glu Arg Glu Pro Arg Arg His Arg Ala His Arg His Gln Asp Pro Ser 
    930                 935                 940                 


Lys Glu Cys Ala Gly Ala Lys Gly Glu Arg Arg Ala Arg His Arg Gly 
945                 950                 955                 960 


Gly Pro Arg Ala Gly Pro Arg Glu Ala Glu Ser Gly Glu Glu Pro Ala 
                965                 970                 975     


Arg Arg His Arg Ala Arg His Lys Ala Gln Pro Ala His Glu Ala Val 
            980                 985                 990         


Glu Lys Glu Thr Thr Glu Lys Glu  Ala Thr Glu Lys Glu  Ala Glu Ile 
        995                 1000                 1005             


Val Glu  Ala Asp Lys Glu Lys  Glu Leu Arg Asn His  Gln Pro Arg 
    1010                 1015                 1020             


Glu Pro  His Cys Asp Leu Glu  Thr Ser Gly Thr Val  Thr Val Gly 
    1025                 1030                 1035             


Pro Met  His Thr Leu Pro Ser  Thr Cys Leu Gln Lys  Val Glu Glu 
    1040                 1045                 1050             


Gln Pro  Glu Asp Ala Asp Asn  Gln Arg Asn Val Thr  Arg Met Gly 
    1055                 1060                 1065             


Ser Gln  Pro Pro Asp Pro Asn  Thr Ile Val His Ile  Pro Val Met 
    1070                 1075                 1080             


Leu Thr  Gly Pro Leu Gly Glu  Ala Thr Val Val Pro  Ser Gly Asn 
    1085                 1090                 1095             


Val Asp  Leu Glu Ser Gln Ala  Glu Gly Lys Lys Glu  Val Glu Ala 
    1100                 1105                 1110             


Asp Asp  Val Met Arg Ser Gly  Pro Arg Pro Ile Val  Pro Tyr Ser 
    1115                 1120                 1125             


Ser Met  Phe Cys Leu Ser Pro  Thr Asn Leu Leu Arg  Arg Phe Cys 
    1130                 1135                 1140             


His Tyr  Ile Val Thr Met Arg  Tyr Phe Glu Val Val  Ile Leu Val 
    1145                 1150                 1155             


Val Ile  Ala Leu Ser Ser Ile  Ala Leu Ala Ala Glu  Asp Pro Val 
    1160                 1165                 1170             


Arg Thr  Asp Ser Pro Arg Asn  Asn Ala Leu Lys Tyr  Leu Asp Tyr 
    1175                 1180                 1185             


Ile Phe  Thr Gly Val Phe Thr  Phe Glu Met Val Ile  Lys Met Ile 
    1190                 1195                 1200             


Asp Leu  Gly Leu Leu Leu His  Pro Gly Ala Tyr Phe  Arg Asp Leu 
    1205                 1210                 1215             


Trp Asn  Ile Leu Asp Phe Ile  Val Val Ser Gly Ala  Leu Val Ala 
    1220                 1225                 1230             


Phe Ala  Phe Ser Gly Ser Lys  Gly Lys Asp Ile Asn  Thr Ile Lys 
    1235                 1240                 1245             


Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro Leu Lys  Thr Ile Lys 
    1250                 1255                 1260             


Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp Cys Val  Val Asn Ser 
    1265                 1270                 1275             


Leu Lys  Asn Val Leu Asn Ile  Leu Ile Val Tyr Met  Leu Phe Met 
    1280                 1285                 1290             


Phe Ile  Phe Ala Val Ile Ala  Val Gln Leu Phe Lys  Gly Lys Phe 
    1295                 1300                 1305             


Phe Tyr  Cys Thr Asp Glu Ser  Lys Glu Leu Glu Arg  Asp Cys Arg 
    1310                 1315                 1320             


Gly Gln  Tyr Leu Asp Tyr Glu  Lys Glu Glu Val Glu  Ala Gln Pro 
    1325                 1330                 1335             


Arg Gln  Trp Lys Lys Tyr Asp  Phe His Tyr Asp Asn  Val Leu Trp 
    1340                 1345                 1350             


Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr Gly Glu  Gly Trp Pro 
    1355                 1360                 1365             


Met Val  Leu Lys His Ser Val  Asp Ala Thr Tyr Glu  Glu Gln Gly 
    1370                 1375                 1380             


Pro Ser  Pro Gly Tyr Arg Met  Glu Leu Ser Ile Phe  Tyr Val Val 
    1385                 1390                 1395             


Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val Asn Ile  Phe Val Ala 
    1400                 1405                 1410             


Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly Asp Lys  Val Met Ser 
    1415                 1420                 1425             


Glu Cys  Ser Leu Glu Lys Asn  Glu Arg Ala Cys Ile  Asp Phe Ala 
    1430                 1435                 1440             


Ile Ser  Ala Lys Pro Leu Thr  Arg Tyr Met Pro Gln  Asn Arg Gln 
    1445                 1450                 1455             


Ser Phe  Gln Tyr Lys Thr Trp  Thr Phe Val Val Ser  Pro Pro Phe 
    1460                 1465                 1470             


Glu Tyr  Phe Ile Met Ala Met  Ile Ala Leu Asn Thr  Val Val Leu 
    1475                 1480                 1485             


Met Met  Lys Phe Tyr Asp Ala  Pro Tyr Glu Tyr Glu  Leu Met Leu 
    1490                 1495                 1500             


Lys Cys  Leu Asn Ile Val Phe  Thr Ser Met Phe Ser  Met Glu Cys 
    1505                 1510                 1515             


Val Leu  Lys Ile Ile Ala Phe  Gly Val Leu Asn Tyr  Phe Arg Asp 
    1520                 1525                 1530             


Ala Trp  Asn Val Phe Asp Phe  Val Thr Val Leu Gly  Ser Ile Thr 
    1535                 1540                 1545             


Asp Ile  Leu Val Thr Glu Ile  Ala Glu Thr Asn Asn  Phe Ile Asn 
    1550                 1555                 1560             


Leu Ser  Phe Leu Arg Leu Phe  Arg Ala Ala Arg Leu  Ile Lys Leu 
    1565                 1570                 1575             


Leu Arg  Gln Gly Tyr Thr Ile  Arg Ile Leu Leu Trp  Thr Phe Val 
    1580                 1585                 1590             


Gln Ser  Phe Lys Ala Leu Pro  Tyr Val Cys Leu Leu  Ile Ala Met 
    1595                 1600                 1605             


Leu Phe  Phe Ile Tyr Ala Ile  Ile Gly Met Gln Val  Phe Gly Asn 
    1610                 1615                 1620             


Ile Ala  Leu Asp Asp Asp Thr  Ser Ile Asn Arg His  Asn Asn Phe 
    1625                 1630                 1635             


Arg Thr  Phe Leu Gln Ala Leu  Met Leu Leu Phe Arg  Ser Ala Thr 
    1640                 1645                 1650             


Gly Glu  Ala Trp His Glu Ile  Met Leu Ser Cys Leu  Ser Asn Gln 
    1655                 1660                 1665             


Ala Cys  Asp Glu Gln Ala Asn  Ala Thr Glu Cys Gly  Ser Asp Phe 
    1670                 1675                 1680             


Ala Tyr  Phe Tyr Phe Val Ser  Phe Ile Phe Leu Cys  Ser Phe Leu 
    1685                 1690                 1695             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1700                 1705                 1710             


Leu Thr  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1715                 1720                 1725             


Phe Ile  Arg Val Trp Ala Glu  Tyr Asp Pro Ala Ala  Cys Gly Arg 
    1730                 1735                 1740             


Ile Ser  Tyr Asn Asp Met Phe  Glu Met Leu Lys His  Met Ser Pro 
    1745                 1750                 1755             


Pro Leu  Gly Leu Gly Lys Lys  Cys Pro Ala Arg Val  Ala Tyr Lys 
    1760                 1765                 1770             


Arg Leu  Val Arg Met Asn Met  Pro Ile Ser Asn Glu  Asp Met Thr 
    1775                 1780                 1785             


Val His  Phe Thr Ser Thr Leu  Met Ala Leu Ile Arg  Thr Ala Leu 
    1790                 1795                 1800             


Glu Ile  Lys Leu Ala Pro Ala  Gly Thr Lys Gln His  Gln Cys Asp 
    1805                 1810                 1815             


Ala Glu  Leu Arg Lys Glu Ile  Ser Val Val Trp Ala  Asn Leu Pro 
    1820                 1825                 1830             


Gln Lys  Thr Leu Asp Leu Leu  Val Pro Pro His Lys  Pro Asp Glu 
    1835                 1840                 1845             


Met Thr  Val Gly Lys Val Tyr  Ala Ala Leu Met Ile  Phe Asp Phe 
    1850                 1855                 1860             


Tyr Lys  Gln Asn Lys Thr Thr  Arg Asp Gln Met Gln  Gln Ala Pro 
    1865                 1870                 1875             


Gly Gly  Leu Ser Gln Met Gly  Pro Val Ser Leu Phe  His Pro Leu 
    1880                 1885                 1890             


Lys Ala  Thr Leu Glu Gln Thr  Gln Pro Ala Val Leu  Arg Gly Ala 
    1895                 1900                 1905             


Arg Val  Phe Leu Arg Gln Lys  Ser Ser Thr Ser Leu  Ser Asn Gly 
    1910                 1915                 1920             


Gly Ala  Ile Gln Asn Gln Glu  Ser Gly Ile Lys Glu  Ser Val Ser 
    1925                 1930                 1935             


Trp Gly  Thr Gln Arg Thr Gln  Asp Ala Pro His Glu  Ala Arg Pro 
    1940                 1945                 1950             


Pro Leu  Glu Arg Gly His Ser  Thr Glu Ile Pro Val  Gly Arg Ser 
    1955                 1960                 1965             


Gly Ala  Leu Ala Val Asp Val  Gln Met Gln Ser Ile  Thr Arg Arg 
    1970                 1975                 1980             


Gly Pro  Asp Gly Glu Pro Gln  Pro Gly Leu Glu Ser  Gln Gly Arg 
    1985                 1990                 1995             


Ala Ala  Ser Met Pro Arg Leu  Ala Ala Glu Thr Gln  Pro Val Thr 
    2000                 2005                 2010             


Asp Ala  Ser Pro Met Lys Arg  Ser Ile Ser Thr Leu  Ala Gln Arg 
    2015                 2020                 2025             


Pro Arg  Gly Thr His Leu Cys  Ser Thr Thr Pro Asp  Arg Pro Pro 
    2030                 2035                 2040             


Pro Ser  Gln Ala Ser Ser His  His His His His Arg  Cys His Arg 
    2045                 2050                 2055             


Arg Arg  Asp Arg Lys Gln Arg  Ser Leu Glu Lys Gly  Pro Ser Leu 
    2060                 2065                 2070             


Ser Ala  Asp Met Asp Gly Ala  Pro Ser Ser Ala Val  Gly Pro Gly 
    2075                 2080                 2085             


Leu Pro  Pro Gly Glu Gly Pro  Thr Gly Cys Arg Arg  Glu Arg Glu 
    2090                 2095                 2100             


Arg Arg  Gln Glu Arg Gly Arg  Ser Gln Glu Arg Arg  Gln Pro Ser 
    2105                 2110                 2115             


Ser Ser  Ser Ser Glu Lys Gln  Arg Phe Tyr Ser Cys  Asp Arg Phe 
    2120                 2125                 2130             


Gly Gly  Arg Glu Pro Pro Lys  Pro Lys Pro Ser Leu  Ser Ser His 
    2135                 2140                 2145             


Pro Thr  Ser Pro Thr Ala Gly  Gln Glu Pro Gly Pro  His Pro Gln 
    2150                 2155                 2160             


Gly Ser  Gly Ser Val Asn Gly  Ser Pro Leu Leu Ser  Thr Ser Gly 
    2165                 2170                 2175             


Ala Ser  Thr Pro Gly Arg Gly  Gly Arg Arg Gln Leu  Pro Gln Thr 
    2180                 2185                 2190             


Pro Leu  Thr Pro Arg Pro Ser  Ile Thr Tyr Lys Thr  Ala Asn Ser 
    2195                 2200                 2205             


Ser Pro  Ile His Phe Ala Gly  Ala Gln Thr Ser Leu  Pro Ala Phe 
    2210                 2215                 2220             


Ser Pro  Gly Arg Leu Ser Arg  Gly Leu Ser Glu His  Asn Ala Leu 
    2225                 2230                 2235             


Leu Gln  Arg Asp Pro Leu Ser  Gln Pro Leu Ala Pro  Gly Ser Arg 
    2240                 2245                 2250             


Ile Gly  Ser Asp Pro Tyr Leu  Gly Gln Arg Leu Asp  Ser Glu Ala 
    2255                 2260                 2265             


Ser Val  His Ala Leu Pro Glu  Asp Thr Leu Thr Phe  Glu Glu Ala 
    2270                 2275                 2280             


Val Ala  Thr Asn Ser Gly Arg  Ser Ser Arg Thr Ser  Tyr Val Ser 
    2285                 2290                 2295             


Ser Leu  Thr Ser Gln Ser His  Pro Leu Arg Arg Val  Pro Asn Gly 
    2300                 2305                 2310             


Tyr His  Cys Thr Leu Gly Leu  Ser Ser Gly Gly Arg  Ala Arg His 
    2315                 2320                 2325             


Ser Tyr  His His Pro Asp Gln  Asp His Trp Cys 
    2330                 2335                 


<210>  1494
<211>  2138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1C__Homo_sapiens__NP_000710

<400>  1494

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys His Tyr 
    1265                 1270                 1275             


Phe Cys  Asp Ala Trp Asn Thr  Phe Asp Ala Leu Ile  Val Val Gly 
    1280                 1285                 1290             


Ser Ile  Val Asp Ile Ala Ile  Thr Glu Val Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Asn Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Ser Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly Tyr Pro  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Ile Arg 
    1790                 1795                 1800             


Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser Asn Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Ala Ala Met  Ala Gly Gln Glu Glu  Thr Ser Gln 
    1820                 1825                 1830             


Asp Glu  Thr Tyr Glu Val Lys  Met Asn His Asp Thr  Glu Ala Cys 
    1835                 1840                 1845             


Ser Glu  Pro Ser Leu Leu Ser  Thr Glu Met Leu Ser  Tyr Gln Asp 
    1850                 1855                 1860             


Asp Glu  Asn Arg Gln Leu Thr  Leu Pro Glu Glu Asp  Lys Arg Asp 
    1865                 1870                 1875             


Ile Arg  Gln Ser Pro Lys Arg  Gly Phe Leu Arg Ser  Ala Ser Leu 
    1880                 1885                 1890             


Gly Arg  Arg Ala Ser Phe His  Leu Glu Cys Leu Lys  Arg Gln Lys 
    1895                 1900                 1905             


Asp Arg  Gly Gly Asp Ile Ser  Gln Lys Thr Val Leu  Pro Leu His 
    1910                 1915                 1920             


Leu Val  His His Gln Ala Leu  Ala Val Ala Gly Leu  Ser Pro Leu 
    1925                 1930                 1935             


Leu Gln  Arg Ser His Ser Pro  Ala Ser Phe Pro Arg  Pro Phe Ala 
    1940                 1945                 1950             


Thr Pro  Pro Ala Thr Pro Gly  Ser Arg Gly Trp Pro  Pro Gln Pro 
    1955                 1960                 1965             


Val Pro  Thr Leu Arg Leu Glu  Gly Val Glu Ser Ser  Glu Lys Leu 
    1970                 1975                 1980             


Asn Ser  Ser Phe Pro Ser Ile  His Cys Gly Ser Trp  Ala Glu Thr 
    1985                 1990                 1995             


Thr Pro  Gly Gly Gly Gly Ser  Ser Ala Ala Arg Arg  Val Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Met Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Ser Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Pro Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Ala Leu Leu  Pro Phe Val Asn Cys  Arg Asp Ala 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Gly Gly  Glu Glu Asp Ala Gly  Cys Val Arg 
    2105                 2110                 2115             


Ala Arg  Gly Arg Pro Ser Glu  Glu Glu Leu Gln Asp  Ser Arg Val 
    2120                 2125                 2130             


Tyr Val  Ser Ser Leu 
    2135             


<210>  1495
<211>  2181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1D__Homo_sapiens__NP_000711

<400>  1495

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                485                 490                 495     


Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp 
            500                 505                 510         


Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp 
        515                 520                 525             


Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr 
    530                 535                 540                 


Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile 
545                 550                 555                 560 


Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp 
                565                 570                 575     


Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val 
            580                 585                 590         


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
        595                 600                 605             


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu 
    610                 615                 620                 


Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys 
625                 630                 635                 640 


Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu 
                645                 650                 655     


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
        675                 680                 685             


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys 
    690                 695                 700                 


Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln 
705                 710                 715                 720 


Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met 
                725                 730                 735     


Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe 
            740                 745                 750         


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
        755                 760                 765             


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala 
    770                 775                 780                 


Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys 
785                 790                 795                 800 


Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile 
                805                 810                 815     


Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp 
            820                 825                 830         


Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg 
    850                 855                 860                 


Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile 
865                 870                 875                 880 


Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg 
                885                 890                 895     


Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile 
            900                 905                 910         


Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro 
        915                 920                 925             


Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr 
    930                 935                 940                 


Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr 
945                 950                 955                 960 


Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn 
                965                 970                 975     


Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile 
            980                 985                 990         


Gln Ser Ser Ala Ile Ser Val Val  Lys Ile Leu Arg Val  Leu Arg Val 
        995                 1000                 1005             


Leu Arg  Pro Leu Arg Ala Ile  Asn Arg Ala Lys Gly  Leu Lys His 
    1010                 1015                 1020             


Val Val  Gln Cys Val Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile 
    1025                 1030                 1035             


Met Ile  Val Thr Thr Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly 
    1040                 1045                 1050             


Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala 
    1055                 1060                 1065             


Lys Ser  Asn Pro Glu Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys 
    1070                 1075                 1080             


Asp Gly  Asp Val Asp Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln 
    1085                 1090                 1095             


Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu Ser Ala  Met Met Ala 
    1100                 1105                 1110             


Leu Phe  Thr Val Ser Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr 
    1115                 1120                 1125             


Lys Ala  Ile Asp Ser Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn 
    1130                 1135                 1140             


His Arg  Val Glu Ile Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile 
    1145                 1150                 1155             


Val Ala  Phe Phe Met Met Asn  Ile Phe Val Gly Phe  Val Ile Val 
    1160                 1165                 1170             


Thr Phe  Gln Glu Gln Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu 
    1175                 1180                 1185             


Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg 
    1190                 1195                 1200             


Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe 
    1205                 1210                 1215             


Trp Tyr  Val Val Asn Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val 
    1220                 1225                 1230             


Leu Ile  Met Leu Asn Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu 
    1235                 1240                 1245             


Gln Ser  Lys Met Phe Asn Asp  Ala Met Asp Ile Leu  Asn Met Val 
    1250                 1255                 1260             


Phe Thr  Gly Val Phe Thr Val  Glu Met Val Leu Lys  Val Ile Ala 
    1265                 1270                 1275             


Phe Lys  Pro Lys Gly Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp 
    1280                 1285                 1290             


Ser Leu  Ile Val Ile Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu 
    1295                 1300                 1305             


Ala Asp  Pro Thr Glu Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr 
    1310                 1315                 1320             


Pro Gly  Asn Ser Glu Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe 
    1325                 1330                 1335             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1340                 1345                 1350             


Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln 
    1355                 1360                 1365             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile 
    1370                 1375                 1380             


Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly Lys Val  Ala Met Arg 
    1385                 1390                 1395             


Asp Asn  Asn Gln Ile Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro 
    1400                 1405                 1410             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp 
    1415                 1420                 1425             


Gln Glu  Ile Met Leu Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro 
    1430                 1435                 1440             


Glu Ser  Asp Tyr Asn Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn 
    1445                 1450                 1455             


Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe 
    1460                 1465                 1470             


Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile Met Asp  Asn Phe Asp 
    1475                 1480                 1485             


Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly Pro His  His Leu Asp 
    1490                 1495                 1500             


Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly 
    1505                 1510                 1515             


Arg Ile  Lys His Leu Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln 
    1520                 1525                 1530             


Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro His Arg  Val Ala Cys 
    1535                 1540                 1545             


Lys Arg  Leu Val Ala Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr 
    1550                 1555                 1560             


Val Met  Phe Asn Ala Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu 
    1565                 1570                 1575             


Lys Ile  Lys Thr Glu Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Val Ile Lys Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala 
    1640                 1645                 1650             


Lys Asn  Thr Thr Ile Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His 
    1655                 1660                 1665             


Asp Ile  Gly Pro Glu Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln 
    1670                 1675                 1680             


Asp Asp  Glu Pro Glu Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val 
    1685                 1690                 1695             


Phe Lys  Arg Asn Gly Ala Leu  Leu Gly Asn His Val  Asn His Val 
    1700                 1705                 1710             


Asn Ser  Asp Arg Arg Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His 
    1715                 1720                 1725             


Arg Pro  Leu His Val Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp 
    1730                 1735                 1740             


Thr Glu  Lys Pro Leu Phe Pro  Pro Ala Gly Asn Ser  Val Cys His 
    1745                 1750                 1755             


Asn His  His Asn His Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser 
    1760                 1765                 1770             


Thr Asn  Ala Asn Leu Asn Asn  Ala Asn Met Ser Lys  Ala Ala His 
    1775                 1780                 1785             


Gly Lys  Arg Pro Ser Ile Gly  Asn Leu Glu His Val  Ser Glu Asn 
    1790                 1795                 1800             


Gly His  His Ser Ser His Lys  His Asp Arg Glu Pro  Gln Arg Arg 
    1805                 1810                 1815             


Ser Ser  Val Lys Arg Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser 
    1820                 1825                 1830             


Asp Ser  Gly Asp Glu Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro 
    1835                 1840                 1845             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln 
    1850                 1855                 1860             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro 
    1865                 1870                 1875             


Thr Trp  Ser Arg Gln Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly 
    1880                 1885                 1890             


Arg Asn  Ile Asp Ser Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1895                 1900                 1905             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg 
    1910                 1915                 1920             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His 
    1925                 1930                 1935             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1940                 1945                 1950             


Gln Glu  Glu Val Pro Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala 
    1955                 1960                 1965             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1970                 1975                 1980             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr 
    1985                 1990                 1995             


Arg Ser  Trp Ala Thr Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp 
    2000                 2005                 2010             


Thr Pro  Cys Tyr Thr Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala 
    2015                 2020                 2025             


Leu Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2030                 2035                 2040             


Trp Tyr  Thr Asp Glu Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro 
    2045                 2050                 2055             


Ala Ser  Leu Thr Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2060                 2065                 2070             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2075                 2080                 2085             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2090                 2095                 2100             


Thr Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu 
    2105                 2110                 2115             


Met Glu  Ser Ala Ala Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro 
    2120                 2125                 2130             


Arg Ala  Asn Gly Asp Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr 
    2135                 2140                 2145             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2150                 2155                 2160             


Pro Gly  Arg Asp Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2165                 2170                 2175             


Thr Thr  Leu 
    2180     


<210>  1496
<211>  2270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1E__Homo_sapiens__NP_000712

<400>  1496

Met Ala Arg Phe Gly Glu Ala Val Val Ala Arg Pro Gly Ser Gly Asp 
1               5                   10                  15      


Gly Asp Ser Asp Gln Ser Arg Asn Arg Gln Gly Thr Pro Val Pro Ala 
            20                  25                  30          


Ser Gly Gln Ala Ala Ala Tyr Lys Gln Thr Lys Ala Gln Arg Ala Arg 
        35                  40                  45              


Thr Met Ala Leu Tyr Asn Pro Ile Pro Val Arg Gln Asn Cys Phe Thr 
    50                  55                  60                  


Val Asn Arg Ser Leu Phe Ile Phe Gly Glu Asp Asn Ile Val Arg Lys 
65                  70                  75                  80  


Tyr Ala Lys Lys Leu Ile Asp Trp Pro Pro Phe Glu Tyr Met Ile Leu 
                85                  90                  95      


Ala Thr Ile Ile Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu 
            100                 105                 110         


Pro Glu Asp Asp Lys Thr Pro Met Ser Arg Arg Leu Glu Lys Thr Glu 
        115                 120                 125             


Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Val 
    130                 135                 140                 


Ala Leu Gly Phe Ile Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp 
145                 150                 155                 160 


Asn Val Met Asp Phe Ile Val Val Leu Ser Gly Ile Leu Ala Thr Ala 
                165                 170                 175     


Gly Thr His Phe Asn Thr His Val Asp Leu Arg Thr Leu Arg Ala Val 
            180                 185                 190         


Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser Leu Gln 
        195                 200                 205             


Ile Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu Gln Ile 
    210                 215                 220                 


Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile Gly Leu 
225                 230                 235                 240 


Glu Phe Tyr Ser Gly Lys Leu His Arg Ala Cys Phe Met Asn Asn Ser 
                245                 250                 255     


Gly Ile Leu Glu Gly Phe Asp Pro Pro His Pro Cys Gly Val Gln Gly 
            260                 265                 270         


Cys Pro Ala Gly Tyr Glu Cys Lys Asp Trp Ile Gly Pro Asn Asp Gly 
        275                 280                 285             


Ile Thr Gln Phe Asp Asn Ile Leu Phe Ala Val Leu Thr Val Phe Gln 
    290                 295                 300                 


Cys Ile Thr Met Glu Gly Trp Thr Thr Val Leu Tyr Asn Thr Asn Asp 
305                 310                 315                 320 


Ala Leu Gly Ala Thr Trp Asn Trp Leu Tyr Phe Ile Pro Leu Ile Ile 
                325                 330                 335     


Ile Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly 
            340                 345                 350         


Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn Arg Arg Ala Phe Met 
        355                 360                 365             


Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu Leu Asn Gly Tyr Arg 
    370                 375                 380                 


Ala Trp Ile Asp Lys Ala Glu Glu Val Met Leu Ala Glu Glu Asn Lys 
385                 390                 395                 400 


Asn Ala Gly Thr Ser Ala Leu Glu Val Leu Arg Arg Ala Thr Ile Lys 
                405                 410                 415     


Arg Ser Arg Thr Glu Ala Met Thr Arg Asp Ser Ser Asp Glu His Cys 
            420                 425                 430         


Val Asp Ile Ser Ser Val Gly Thr Pro Leu Ala Arg Ala Ser Ile Lys 
        435                 440                 445             


Ser Ala Lys Val Asp Gly Val Ser Tyr Phe Arg His Lys Glu Arg Leu 
    450                 455                 460                 


Leu Arg Ile Ser Ile Arg His Met Val Lys Ser Gln Val Phe Tyr Trp 
465                 470                 475                 480 


Ile Val Leu Ser Leu Val Ala Leu Asn Thr Ala Cys Val Ala Ile Val 
                485                 490                 495     


His His Asn Gln Pro Gln Trp Leu Thr His Leu Leu Tyr Tyr Ala Glu 
            500                 505                 510         


Phe Leu Phe Leu Gly Leu Phe Leu Leu Glu Met Ser Leu Lys Met Tyr 
        515                 520                 525             


Gly Met Gly Pro Arg Leu Tyr Phe His Ser Ser Phe Asn Cys Phe Asp 
    530                 535                 540                 


Phe Gly Val Thr Val Gly Ser Ile Phe Glu Val Val Trp Ala Ile Phe 
545                 550                 555                 560 


Arg Pro Gly Thr Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu 
                565                 570                 575     


Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu 
            580                 585                 590         


Val Val Ser Leu Met Ser Ser Met Lys Ser Ile Ile Ser Leu Leu Phe 
        595                 600                 605             


Leu Leu Phe Leu Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu 
    610                 615                 620                 


Phe Gly Gly Arg Phe Asn Phe Asn Asp Gly Thr Pro Ser Ala Asn Phe 
625                 630                 635                 640 


Asp Thr Phe Pro Ala Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly 
                645                 650                 655     


Glu Asp Trp Asn Glu Val Met Tyr Asn Gly Ile Arg Ser Gln Gly Gly 
            660                 665                 670         


Val Ser Ser Gly Met Trp Ser Ala Ile Tyr Phe Ile Val Leu Thr Leu 
        675                 680                 685             


Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp 
    690                 695                 700                 


Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Phe Asn Gln Lys His Ala Leu Gln Lys Ala Lys Glu Val Ser 
                725                 730                 735     


Pro Met Ser Ala Pro Asn Met Pro Ser Ile Glu Arg Asp Arg Arg Arg 
            740                 745                 750         


Arg His His Met Ser Met Trp Glu Pro Arg Ser Ser His Leu Arg Glu 
        755                 760                 765             


Arg Arg Arg Arg His His Met Ser Val Trp Glu Gln Arg Thr Ser Gln 
    770                 775                 780                 


Leu Arg Lys His Met Gln Met Ser Ser Gln Glu Ala Leu Asn Arg Glu 
785                 790                 795                 800 


Glu Ala Pro Thr Met Asn Pro Leu Asn Pro Leu Asn Pro Leu Ser Ser 
                805                 810                 815     


Leu Asn Pro Leu Asn Ala His Pro Ser Leu Tyr Arg Arg Pro Arg Ala 
            820                 825                 830         


Ile Glu Gly Leu Ala Leu Gly Leu Ala Leu Glu Lys Phe Glu Glu Glu 
        835                 840                 845             


Arg Ile Ser Arg Gly Gly Ser Leu Lys Gly Asp Gly Gly Asp Arg Ser 
    850                 855                 860                 


Ser Ala Leu Asp Asn Gln Arg Thr Pro Leu Ser Leu Gly Gln Arg Glu 
865                 870                 875                 880 


Pro Pro Trp Leu Ala Arg Pro Cys His Gly Asn Cys Asp Pro Thr Gln 
                885                 890                 895     


Gln Glu Ala Gly Gly Gly Glu Ala Val Val Thr Phe Glu Asp Arg Ala 
            900                 905                 910         


Arg His Arg Gln Ser Gln Arg Arg Ser Arg His Arg Arg Val Arg Thr 
        915                 920                 925             


Glu Gly Lys Glu Ser Ser Ser Ala Ser Arg Ser Arg Ser Ala Ser Gln 
    930                 935                 940                 


Glu Arg Ser Leu Asp Glu Ala Met Pro Thr Glu Gly Glu Lys Asp His 
945                 950                 955                 960 


Glu Leu Arg Gly Asn His Gly Ala Lys Glu Pro Thr Ile Gln Glu Glu 
                965                 970                 975     


Arg Ala Gln Asp Leu Arg Arg Thr Asn Ser Leu Met Val Ser Arg Gly 
            980                 985                 990         


Ser Gly Leu Ala Gly Gly Leu Asp  Glu Ala Asp Thr Pro  Leu Val Leu 
        995                 1000                 1005             


Pro His  Pro Glu Leu Glu Val  Gly Lys His Val Val  Leu Thr Glu 
    1010                 1015                 1020             


Gln Glu  Pro Glu Gly Ser Ser  Glu Gln Ala Leu Leu  Gly Asn Val 
    1025                 1030                 1035             


Gln Leu  Asp Met Gly Arg Val  Ile Ser Gln Ser Glu  Pro Asp Leu 
    1040                 1045                 1050             


Ser Cys  Ile Thr Ala Asn Thr  Asp Lys Ala Thr Thr  Glu Ser Thr 
    1055                 1060                 1065             


Ser Val  Thr Val Ala Ile Pro  Asp Val Asp Pro Leu  Val Asp Ser 
    1070                 1075                 1080             


Thr Val  Val His Ile Ser Asn  Lys Thr Asp Gly Glu  Ala Ser Pro 
    1085                 1090                 1095             


Leu Lys  Glu Ala Glu Ile Arg  Glu Asp Glu Glu Glu  Val Glu Lys 
    1100                 1105                 1110             


Lys Lys  Gln Lys Lys Glu Lys  Arg Glu Thr Gly Lys  Ala Met Val 
    1115                 1120                 1125             


Pro His  Ser Ser Met Phe Ile  Phe Ser Thr Thr Asn  Pro Ile Arg 
    1130                 1135                 1140             


Arg Ala  Cys His Tyr Ile Val  Asn Leu Arg Tyr Phe  Glu Met Cys 
    1145                 1150                 1155             


Ile Leu  Leu Val Ile Ala Ala  Ser Ser Ile Ala Leu  Ala Ala Glu 
    1160                 1165                 1170             


Asp Pro  Val Leu Thr Asn Ser  Glu Arg Asn Lys Val  Leu Arg Tyr 
    1175                 1180                 1185             


Phe Asp  Tyr Val Phe Thr Gly  Val Phe Thr Phe Glu  Met Val Ile 
    1190                 1195                 1200             


Lys Met  Ile Asp Gln Gly Leu  Ile Leu Gln Asp Gly  Ser Tyr Phe 
    1205                 1210                 1215             


Arg Asp  Leu Trp Asn Ile Leu  Asp Phe Val Val Val  Val Gly Ala 
    1220                 1225                 1230             


Leu Val  Ala Phe Ala Leu Ala  Asn Ala Leu Gly Thr  Asn Lys Gly 
    1235                 1240                 1245             


Arg Asp  Ile Lys Thr Ile Lys  Ser Leu Arg Val Leu  Arg Val Leu 
    1250                 1255                 1260             


Arg Pro  Leu Lys Thr Ile Lys  Arg Leu Pro Lys Leu  Lys Ala Val 
    1265                 1270                 1275             


Phe Asp  Cys Val Val Thr Ser  Leu Lys Asn Val Phe  Asn Ile Leu 
    1280                 1285                 1290             


Ile Val  Tyr Lys Leu Phe Met  Phe Ile Phe Ala Val  Ile Ala Val 
    1295                 1300                 1305             


Gln Leu  Phe Lys Gly Lys Phe  Phe Tyr Cys Thr Asp  Ser Ser Lys 
    1310                 1315                 1320             


Asp Thr  Glu Lys Glu Cys Ile  Gly Asn Tyr Val Asp  His Glu Lys 
    1325                 1330                 1335             


Asn Lys  Met Glu Val Lys Gly  Arg Glu Trp Lys Arg  His Glu Phe 
    1340                 1345                 1350             


His Tyr  Asp Asn Ile Ile Trp  Ala Leu Leu Thr Leu  Phe Thr Val 
    1355                 1360                 1365             


Ser Thr  Gly Glu Gly Trp Pro  Gln Val Leu Gln His  Ser Val Asp 
    1370                 1375                 1380             


Val Thr  Glu Glu Asp Arg Gly  Pro Ser Arg Ser Asn  Arg Met Glu 
    1385                 1390                 1395             


Met Ser  Ile Phe Tyr Val Val  Tyr Phe Val Val Phe  Pro Phe Phe 
    1400                 1405                 1410             


Phe Val  Asn Ile Phe Val Ala  Leu Ile Ile Ile Thr  Phe Gln Glu 
    1415                 1420                 1425             


Gln Gly  Asp Lys Met Met Glu  Glu Cys Ser Leu Glu  Lys Asn Glu 
    1430                 1435                 1440             


Arg Ala  Cys Ile Asp Phe Ala  Ile Ser Ala Lys Pro  Leu Thr Arg 
    1445                 1450                 1455             


Tyr Met  Pro Gln Asn Arg His  Thr Phe Gln Tyr Arg  Val Trp His 
    1460                 1465                 1470             


Phe Val  Val Ser Pro Ser Phe  Glu Tyr Thr Ile Met  Ala Met Ile 
    1475                 1480                 1485             


Ala Leu  Asn Thr Val Val Leu  Met Met Lys Tyr Tyr  Ser Ala Pro 
    1490                 1495                 1500             


Cys Thr  Tyr Glu Leu Ala Leu  Lys Tyr Leu Asn Ile  Ala Phe Thr 
    1505                 1510                 1515             


Met Val  Phe Ser Leu Glu Cys  Val Leu Lys Val Ile  Ala Phe Gly 
    1520                 1525                 1530             


Phe Leu  Asn Tyr Phe Arg Asp  Thr Trp Asn Ile Phe  Asp Phe Ile 
    1535                 1540                 1545             


Thr Val  Ile Gly Ser Ile Thr  Glu Ile Ile Leu Thr  Asp Ser Lys 
    1550                 1555                 1560             


Leu Val  Asn Thr Ser Gly Phe  Asn Met Ser Phe Leu  Lys Leu Phe 
    1565                 1570                 1575             


Arg Ala  Ala Arg Leu Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile 
    1580                 1585                 1590             


Arg Ile  Leu Leu Trp Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro 
    1595                 1600                 1605             


Tyr Val  Cys Leu Leu Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile 
    1610                 1615                 1620             


Ile Gly  Met Gln Val Phe Gly  Asn Ile Lys Leu Asp  Glu Glu Ser 
    1625                 1630                 1635             


His Ile  Asn Arg His Asn Asn  Phe Arg Ser Phe Phe  Gly Ser Leu 
    1640                 1645                 1650             


Met Leu  Leu Phe Arg Ser Ala  Thr Gly Glu Ala Trp  Gln Glu Ile 
    1655                 1660                 1665             


Met Leu  Ser Cys Leu Gly Glu  Lys Gly Cys Glu Pro  Asp Thr Thr 
    1670                 1675                 1680             


Ala Pro  Ser Gly Gln Asn Glu  Asn Glu Arg Cys Gly  Thr Asp Leu 
    1685                 1690                 1695             


Ala Tyr  Val Tyr Phe Val Ser  Phe Ile Phe Phe Cys  Ser Phe Leu 
    1700                 1705                 1710             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1715                 1720                 1725             


Leu Thr  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1730                 1735                 1740             


Phe Val  Arg Val Trp Ala Glu  Tyr Asp Arg Ala Ala  Cys Gly Arg 
    1745                 1750                 1755             


Ile His  Tyr Thr Glu Met Tyr  Glu Met Leu Thr Leu  Met Ser Pro 
    1760                 1765                 1770             


Pro Leu  Gly Leu Gly Lys Arg  Cys Pro Ser Lys Val  Ala Tyr Lys 
    1775                 1780                 1785             


Arg Leu  Val Leu Met Asn Met  Pro Val Ala Glu Asp  Met Thr Val 
    1790                 1795                 1800             


His Phe  Thr Ser Thr Leu Met  Ala Leu Ile Arg Thr  Ala Leu Asp 
    1805                 1810                 1815             


Ile Lys  Ile Ala Lys Gly Gly  Ala Asp Arg Gln Gln  Leu Asp Ser 
    1820                 1825                 1830             


Glu Leu  Gln Lys Glu Thr Leu  Ala Ile Trp Pro His  Leu Ser Gln 
    1835                 1840                 1845             


Lys Met  Leu Asp Leu Leu Val  Pro Met Pro Lys Ala  Ser Asp Leu 
    1850                 1855                 1860             


Thr Val  Gly Lys Ile Tyr Ala  Ala Met Met Ile Met  Asp Tyr Tyr 
    1865                 1870                 1875             


Lys Gln  Ser Lys Val Lys Lys  Gln Arg Gln Gln Leu  Glu Glu Gln 
    1880                 1885                 1890             


Lys Asn  Ala Pro Met Phe Gln  Arg Met Glu Pro Ser  Ser Leu Pro 
    1895                 1900                 1905             


Gln Glu  Ile Ile Ala Asn Ala  Lys Ala Leu Pro Tyr  Leu Gln Gln 
    1910                 1915                 1920             


Asp Pro  Val Ser Gly Leu Ser  Gly Arg Ser Gly Tyr  Pro Ser Met 
    1925                 1930                 1935             


Ser Pro  Leu Ser Pro Gln Asp  Ile Phe Gln Leu Ala  Cys Met Asp 
    1940                 1945                 1950             


Pro Ala  Asp Asp Gly Gln Phe  Gln Glu Arg Gln Ser  Leu Val Val 
    1955                 1960                 1965             


Thr Asp  Pro Ser Ser Met Arg  Arg Ser Phe Ser Thr  Ile Arg Asp 
    1970                 1975                 1980             


Lys Arg  Ser Asn Ser Ser Trp  Leu Glu Glu Phe Ser  Met Glu Arg 
    1985                 1990                 1995             


Ser Ser  Glu Asn Thr Tyr Lys  Ser Arg Arg Arg Ser  Tyr His Ser 
    2000                 2005                 2010             


Ser Leu  Arg Leu Ser Ala His  Arg Leu Asn Ser Asp  Ser Gly His 
    2015                 2020                 2025             


Lys Ser  Asp Thr His Arg Ser  Gly Gly Arg Glu Arg  Gly Arg Ser 
    2030                 2035                 2040             


Lys Glu  Arg Lys His Leu Leu  Ser Pro Asp Val Ser  Arg Cys Asn 
    2045                 2050                 2055             


Ser Glu  Glu Arg Gly Thr Gln  Ala Asp Trp Glu Ser  Pro Glu Arg 
    2060                 2065                 2070             


Arg Gln  Ser Arg Ser Pro Ser  Glu Gly Arg Ser Gln  Thr Pro Asn 
    2075                 2080                 2085             


Arg Gln  Gly Thr Gly Ser Leu  Ser Glu Ser Ser Ile  Pro Ser Val 
    2090                 2095                 2100             


Ser Asp  Thr Ser Thr Pro Arg  Arg Ser Arg Arg Gln  Leu Pro Pro 
    2105                 2110                 2115             


Val Pro  Pro Lys Pro Arg Pro  Leu Leu Ser Tyr Ser  Ser Leu Ile 
    2120                 2125                 2130             


Arg His  Ala Gly Ser Ile Ser  Pro Pro Ala Asp Gly  Ser Glu Glu 
    2135                 2140                 2145             


Gly Ser  Pro Leu Thr Ser Gln  Ala Leu Glu Ser Asn  Asn Ala Cys 
    2150                 2155                 2160             


Leu Thr  Glu Ser Ser Asn Ser  Pro His Pro Gln Gln  Ser Gln His 
    2165                 2170                 2175             


Ala Ser  Pro Gln Arg Tyr Ile  Ser Glu Pro Tyr Leu  Ala Leu His 
    2180                 2185                 2190             


Glu Asp  Ser His Ala Ser Asp  Cys Gly Glu Glu Glu  Thr Leu Thr 
    2195                 2200                 2205             


Phe Glu  Ala Ala Val Ala Thr  Ser Leu Gly Arg Ser  Asn Thr Ile 
    2210                 2215                 2220             


Gly Ser  Ala Pro Pro Leu Arg  His Ser Trp Gln Met  Pro Asn Gly 
    2225                 2230                 2235             


His Tyr  Arg Arg Arg Arg Arg  Gly Gly Pro Gly Pro  Gly Met Met 
    2240                 2245                 2250             


Cys Gly  Ala Val Asn Asn Leu  Leu Ser Asp Thr Glu  Glu Asp Asp 
    2255                 2260                 2265             


Lys Cys  
    2270 


<210>  1497
<211>  1966
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1F__Homo_sapiens__NP_001243718

<400>  1497

Met Ser Glu Ser Glu Gly Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Thr Leu Asn Gln Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Val Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Pro Gln Leu Ala Glu Leu 
            420                 425                 430         


Thr Asn Arg Arg Arg Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg 
        435                 440                 445             


Ser Thr His Ser Thr Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr 
    450                 455                 460                 


Gly Ser Met Thr Glu Thr Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala 
465                 470                 475                 480 


Leu Ala Ser Cys Thr Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Val 
                485                 490                 495     


Cys Arg Arg Leu Arg Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg 
            500                 505                 510         


Arg Ala Val Lys Ser Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val 
        515                 520                 525             


Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu His His Gly Gln Pro Val 
    530                 535                 540                 


Trp Leu Thr Gln Ile Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu 
545                 550                 555                 560 


Phe Thr Val Glu Met Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala 
                565                 570                 575     


Tyr Val Ser Ser Phe Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly 
            580                 585                 590         


Gly Ile Leu Glu Thr Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu 
        595                 600                 605             


Gly Ile Ser Val Leu Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val 
    610                 615                 620                 


Thr Arg His Trp Ala Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn 
625                 630                 635                 640 


Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile 
                645                 650                 655     


Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn 
            660                 665                 670         


Phe Asp Gln Thr His Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln 
        675                 680                 685             


Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val 
    690                 695                 700                 


Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly 
705                 710                 715                 720 


Met Leu Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr 
                725                 730                 735     


Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser 
            740                 745                 750         


Gly Asp Ala Gly Thr Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu 
        755                 760                 765             


Lys Asp Leu Pro Gln Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys 
    770                 775                 780                 


Glu Glu Glu Glu Gly Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu 
785                 790                 795                 800 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala 
                805                 810                 815     


Gly Gly Val Glu Leu Leu Gln Glu Val Val Pro Lys Glu Lys Val Val 
            820                 825                 830         


Pro Ile Pro Glu Gly Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro 
        835                 840                 845             


Leu Arg Lys Gly Cys His Thr Leu Ile His His His Val Phe Thr Asn 
    850                 855                 860                 


Leu Ile Leu Val Phe Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu 
865                 870                 875                 880 


Asp Pro Ile Arg Ala His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe 
                885                 890                 895     


Asp Tyr Ala Phe Thr Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met 
            900                 905                 910         


Thr Val Phe Gly Ala Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp 
        915                 920                 925             


Phe Asn Met Leu Asp Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe 
    930                 935                 940                 


Gly Ile His Ser Ser Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu 
945                 950                 955                 960 


Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys 
                965                 970                 975     


His Val Val Gln Cys Val Phe Val Ala Ile Arg Thr Ile Gly Asn Ile 
            980                 985                 990         


Met Ile Val Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
        995                 1000                 1005             


Gln Leu  Phe Lys Gly Lys Phe  Tyr Thr Cys Thr Asp  Glu Ala Lys 
    1010                 1015                 1020             


His Thr  Pro Gln Glu Cys Lys  Gly Ser Phe Leu Val  Tyr Pro Asp 
    1025                 1030                 1035             


Gly Asp  Val Ser Arg Pro Leu  Val Arg Glu Arg Leu  Trp Val Asn 
    1040                 1045                 1050             


Ser Asp  Phe Asn Phe Asp Asn  Val Leu Ser Ala Met  Met Ala Leu 
    1055                 1060                 1065             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Ala Leu  Leu Tyr Lys 
    1070                 1075                 1080             


Ala Ile  Asp Ala Tyr Ala Glu  Asp His Gly Pro Ile  Tyr Asn Tyr 
    1085                 1090                 1095             


Arg Val  Glu Ile Ser Val Phe  Phe Ile Val Tyr Ile  Ile Ile Ile 
    1100                 1105                 1110             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Ile Thr 
    1115                 1120                 1125             


Phe Arg  Ala Gln Gly Glu Gln  Glu Tyr Gln Asn Cys  Glu Leu Asp 
    1130                 1135                 1140             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Gln Pro 
    1145                 1150                 1155             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Pro His Gln Tyr  Arg Val Trp 
    1160                 1165                 1170             


Ala Thr  Val Asn Ser Ala Ala  Phe Glu Tyr Leu Met  Phe Leu Leu 
    1175                 1180                 1185             


Ile Leu  Leu Asn Thr Val Ala  Leu Ala Met Gln His  Tyr Glu Gln 
    1190                 1195                 1200             


Thr Ala  Pro Phe Asn Tyr Ala  Met Asp Ile Leu Asn  Met Val Phe 
    1205                 1210                 1215             


Thr Gly  Leu Phe Thr Ile Glu  Met Val Leu Lys Ile  Ile Ala Phe 
    1220                 1225                 1230             


Lys Pro  Lys His Tyr Phe Thr  Asp Ala Trp Asn Thr  Phe Asp Ala 
    1235                 1240                 1245             


Leu Ile  Val Val Gly Ser Ile  Val Asp Ile Ala Val  Thr Glu Val 
    1250                 1255                 1260             


Asn Asn  Gly Gly His Leu Gly  Glu Ser Ser Glu Asp  Ser Ser Arg 
    1265                 1270                 1275             


Ile Ser  Ile Thr Phe Phe Arg  Leu Phe Arg Val Met  Arg Leu Val 
    1280                 1285                 1290             


Lys Leu  Leu Ser Lys Gly Glu  Gly Ile Arg Thr Leu  Leu Trp Thr 
    1295                 1300                 1305             


Phe Ile  Lys Ser Phe Gln Ala  Leu Pro Tyr Val Ala  Leu Leu Ile 
    1310                 1315                 1320             


Ala Met  Ile Phe Phe Ile Tyr  Ala Val Ile Gly Met  Gln Met Phe 
    1325                 1330                 1335             


Gly Lys  Val Ala Leu Gln Asp  Gly Thr Gln Ile Asn  Arg Asn Asn 
    1340                 1345                 1350             


Asn Phe  Gln Thr Phe Pro Gln  Ala Val Leu Leu Leu  Phe Arg Cys 
    1355                 1360                 1365             


Ala Thr  Gly Glu Ala Trp Gln  Glu Ile Met Leu Ala  Ser Leu Pro 
    1370                 1375                 1380             


Gly Asn  Arg Cys Asp Pro Glu  Ser Asp Phe Gly Pro  Gly Glu Glu 
    1385                 1390                 1395             


Phe Thr  Cys Gly Ser Asn Phe  Ala Ile Ala Tyr Phe  Ile Ser Phe 
    1400                 1405                 1410             


Phe Met  Leu Cys Ala Phe Leu  Ile Ile Asn Leu Phe  Val Ala Val 
    1415                 1420                 1425             


Ile Met  Asp Asn Phe Asp Tyr  Leu Thr Arg Asp Trp  Ser Ile Leu 
    1430                 1435                 1440             


Gly Pro  His His Leu Asp Glu  Phe Lys Arg Ile Trp  Ser Glu Tyr 
    1445                 1450                 1455             


Asp Pro  Gly Ala Lys Gly Arg  Ile Lys His Leu Asp  Val Val Ala 
    1460                 1465                 1470             


Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly Phe Gly  Lys Leu Cys 
    1475                 1480                 1485             


Pro His  Arg Val Ala Cys Lys  Arg Leu Val Ala Met  Asn Met Pro 
    1490                 1495                 1500             


Leu Asn  Ser Asp Gly Thr Val  Thr Phe Asn Ala Thr  Leu Phe Ala 
    1505                 1510                 1515             


Leu Val  Arg Thr Ser Leu Lys  Ile Lys Thr Glu Gly  Asn Leu Glu 
    1520                 1525                 1530             


Gln Ala  Asn Gln Glu Leu Arg  Ile Val Ile Lys Lys  Ile Trp Lys 
    1535                 1540                 1545             


Arg Met  Lys Gln Lys Leu Leu  Asp Glu Val Ile Pro  Pro Pro Asp 
    1550                 1555                 1560             


Glu Glu  Glu Val Thr Val Gly  Lys Phe Tyr Ala Thr  Phe Leu Ile 
    1565                 1570                 1575             


Gln Asp  Tyr Phe Arg Lys Phe  Arg Arg Arg Lys Glu  Lys Gly Leu 
    1580                 1585                 1590             


Leu Gly  Asn Asp Ala Ala Pro  Ser Thr Ser Ser Ala  Leu Gln Ala 
    1595                 1600                 1605             


Gly Leu  Arg Ser Leu Gln Asp  Leu Gly Pro Glu Met  Arg Gln Ala 
    1610                 1615                 1620             


Leu Thr  Cys Asp Thr Glu Glu  Glu Glu Glu Glu Gly  Gln Glu Gly 
    1625                 1630                 1635             


Val Glu  Glu Glu Asp Glu Lys  Asp Leu Glu Thr Asn  Lys Ala Thr 
    1640                 1645                 1650             


Met Val  Ser Gln Pro Ser Ala  Arg Arg Gly Ser Gly  Ile Ser Val 
    1655                 1660                 1665             


Ser Leu  Pro Val Gly Asp Arg  Leu Pro Asp Ser Leu  Ser Phe Gly 
    1670                 1675                 1680             


Pro Ser  Asp Asp Asp Arg Gly  Thr Pro Thr Ser Ser  Gln Pro Ser 
    1685                 1690                 1695             


Val Pro  Gln Ala Gly Ser Asn  Thr His Arg Arg Gly  Ser Gly Ala 
    1700                 1705                 1710             


Leu Ile  Phe Thr Ile Pro Glu  Glu Gly Asn Ser Gln  Pro Lys Gly 
    1715                 1720                 1725             


Thr Lys  Gly Gln Asn Lys Gln  Asp Glu Asp Glu Glu  Val Pro Asp 
    1730                 1735                 1740             


Arg Leu  Ser Tyr Leu Asp Glu  Gln Ala Gly Thr Pro  Pro Cys Ser 
    1745                 1750                 1755             


Val Leu  Leu Pro Pro His Arg  Ala Gln Arg Tyr Met  Asp Gly His 
    1760                 1765                 1770             


Leu Val  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Gly Arg 
    1775                 1780                 1785             


Lys Pro  Ser Phe Thr Ile Gln  Cys Leu Gln Arg Gln  Gly Ser Cys 
    1790                 1795                 1800             


Glu Asp  Leu Pro Ile Pro Gly  Thr Tyr His Arg Gly  Arg Asn Ser 
    1805                 1810                 1815             


Gly Pro  Asn Arg Ala Gln Gly  Ser Trp Ala Thr Pro  Pro Gln Arg 
    1820                 1825                 1830             


Gly Arg  Leu Leu Tyr Ala Pro  Leu Leu Leu Val Glu  Glu Gly Ala 
    1835                 1840                 1845             


Ala Gly  Glu Gly Tyr Leu Gly  Arg Ser Ser Gly Pro  Leu Arg Thr 
    1850                 1855                 1860             


Phe Thr  Cys Leu His Val Pro  Gly Thr His Ser Asp  Pro Ser His 
    1865                 1870                 1875             


Gly Lys  Arg Gly Ser Ala Asp  Ser Leu Val Glu Ala  Val Leu Ile 
    1880                 1885                 1890             


Ser Glu  Gly Leu Gly Leu Phe  Ala Arg Asp Pro Arg  Phe Val Ala 
    1895                 1900                 1905             


Leu Ala  Lys Gln Glu Ile Ala  Asp Ala Cys Arg Leu  Thr Leu Asp 
    1910                 1915                 1920             


Glu Met  Asp Asn Ala Ala Ser  Asp Leu Leu Ala Gln  Gly Thr Ser 
    1925                 1930                 1935             


Ser Leu  Tyr Ser Asp Glu Glu  Ser Ile Leu Ser Arg  Phe Asp Glu 
    1940                 1945                 1950             


Glu Asp  Leu Gly Asp Glu Met  Ala Cys Val His Ala  Leu 
    1955                 1960                 1965     


<210>  1498
<211>  2314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1G__Homo_sapiens__NP_001243253

<400>  1498

Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Thr Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Thr Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu Asp Thr Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Thr Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Thr Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Thr Thr Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Thr Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Thr 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln Phe Ser Glu 
385                 390                 395                 400 


Thr Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Thr Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Thr Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Thr Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Thr Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Thr Val Gly Ser Gly Lys Val Tyr Pro Thr 
            580                 585                 590         


Val His Thr Ser Pro Pro Pro Glu Thr Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Thr Leu Thr Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Thr Gln Ser 
625                 630                 635                 640 


Thr Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Thr Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Thr Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Thr Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Thr Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Thr Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Thr Met Asp Asn 
    850                 855                 860                 


Val Ala Thr Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Thr Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Thr Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Thr Ala Ala  Thr Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Thr Ser  Thr Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Thr Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Thr Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Thr Leu Gln Val  Pro Gly Leu His Arg  Thr Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Thr His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Thr Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Thr Leu Ser Asn Tyr  Ile Phe Thr Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Thr Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Thr Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Thr  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Thr Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Thr Arg Asn Ile Thr  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Lys Ala  Gln Cys Lys Pro Tyr  Tyr Ser Asp 
    1565                 1570                 1575             


Tyr Ser  Arg Phe Arg Leu Leu  Val His His Leu Cys  Thr Ser His 
    1580                 1585                 1590             


Tyr Leu  Asp Leu Phe Ile Thr  Gly Val Ile Gly Leu  Asn Val Val 
    1595                 1600                 1605             


Thr Met  Ala Met Glu His Tyr  Gln Gln Pro Gln Ile  Leu Asp Glu 
    1610                 1615                 1620             


Ala Leu  Lys Ile Cys Asn Tyr  Ile Phe Thr Val Ile  Phe Val Leu 
    1625                 1630                 1635             


Glu Ser  Val Phe Lys Leu Val  Ala Phe Gly Phe Arg  Arg Phe Phe 
    1640                 1645                 1650             


Gln Asp  Arg Trp Asn Gln Leu  Asp Leu Ala Ile Val  Leu Leu Ser 
    1655                 1660                 1665             


Ile Met  Gly Ile Thr Leu Glu  Glu Ile Glu Val Asn  Ala Ser Leu 
    1670                 1675                 1680             


Pro Ile  Asn Pro Thr Ile Ile  Arg Ile Met Arg Val  Leu Arg Ile 
    1685                 1690                 1695             


Ala Arg  Val Leu Lys Leu Leu  Lys Met Ala Val Gly  Met Arg Ala 
    1700                 1705                 1710             


Leu Leu  Asp Thr Val Met Gln  Ala Leu Pro Gln Val  Gly Asn Leu 
    1715                 1720                 1725             


Gly Leu  Leu Phe Met Leu Leu  Phe Phe Ile Phe Ala  Ala Leu Gly 
    1730                 1735                 1740             


Val Glu  Leu Phe Gly Asp Leu  Glu Cys Asp Glu Thr  His Pro Cys 
    1745                 1750                 1755             


Glu Gly  Leu Gly Arg His Ala  Thr Phe Arg Asn Phe  Gly Met Ala 
    1760                 1765                 1770             


Phe Leu  Thr Leu Phe Arg Val  Ser Thr Gly Asp Asn  Trp Asn Gly 
    1775                 1780                 1785             


Ile Met  Lys Asp Thr Leu Arg  Asp Cys Asp Gln Glu  Ser Thr Cys 
    1790                 1795                 1800             


Tyr Asn  Thr Val Ile Ser Pro  Ile Tyr Phe Val Ser  Phe Val Leu 
    1805                 1810                 1815             


Thr Ala  Gln Phe Val Leu Val  Asn Val Val Ile Ala  Val Leu Met 
    1820                 1825                 1830             


Lys His  Leu Glu Glu Ser Asn  Lys Glu Ala Lys Glu  Glu Ala Glu 
    1835                 1840                 1845             


Leu Glu  Ala Glu Leu Glu Leu  Glu Met Lys Thr Leu  Ser Pro Gln 
    1850                 1855                 1860             


Pro His  Ser Pro Leu Gly Ser  Pro Phe Leu Trp Pro  Gly Val Glu 
    1865                 1870                 1875             


Gly Pro  Asp Ser Pro Asp Ser  Pro Lys Pro Gly Ala  Leu His Pro 
    1880                 1885                 1890             


Ala Ala  His Ala Arg Ser Ala  Ser His Phe Ser Leu  Glu His Pro 
    1895                 1900                 1905             


Thr Asp  Arg Gln Leu Phe Asp  Thr Ile Ser Leu Leu  Ile Gln Gly 
    1910                 1915                 1920             


Ser Leu  Glu Trp Glu Leu Lys  Leu Met Asp Glu Leu  Ala Gly Pro 
    1925                 1930                 1935             


Gly Gly  Gln Pro Ser Ala Phe  Pro Ser Ala Pro Ser  Leu Gly Gly 
    1940                 1945                 1950             


Ser Asp  Pro Gln Met Gln Pro  His Pro Thr Glu Leu  Pro Gly Pro 
    1955                 1960                 1965             


Asp Leu  Leu Thr Val Arg Lys  Ser Gly Val Ser Arg  Thr His Ser 
    1970                 1975                 1980             


Leu Pro  Asn Asp Ser Tyr Met  Cys Arg His Gly Ser  Thr Ala Glu 
    1985                 1990                 1995             


Gly Pro  Leu Gly His Arg Gly  Trp Gly Leu Pro Lys  Ala Gln Ser 
    2000                 2005                 2010             


Gly Ser  Val Leu Ser Val His  Ser Gln Pro Ala Asp  Thr Ser Tyr 
    2015                 2020                 2025             


Ile Leu  Gln Leu Pro Lys Asp  Ala Pro His Leu Leu  Gln Pro His 
    2030                 2035                 2040             


Ser Ala  Pro Thr Trp Gly Thr  Ile Pro Lys Leu Pro  Pro Pro Gly 
    2045                 2050                 2055             


Arg Ser  Pro Leu Ala Gln Arg  Pro Leu Arg Arg Gln  Ala Ala Ile 
    2060                 2065                 2070             


Arg Thr  Asp Ser Leu Asp Val  Gln Gly Leu Gly Ser  Arg Glu Asp 
    2075                 2080                 2085             


Leu Leu  Ala Glu Val Ser Gly  Pro Ser Pro Pro Leu  Ala Arg Ala 
    2090                 2095                 2100             


Tyr Ser  Phe Trp Gly Gln Ser  Ser Thr Gln Ala Gln  Gln His Ser 
    2105                 2110                 2115             


Arg Ser  His Ser Lys Ile Ser  Lys His Met Thr Pro  Pro Ala Pro 
    2120                 2125                 2130             


Cys Pro  Gly Pro Glu Pro Asn  Trp Gly Lys Gly Pro  Pro Glu Thr 
    2135                 2140                 2145             


Arg Ser  Ser Leu Glu Leu Asp  Thr Glu Leu Ser Trp  Ile Ser Gly 
    2150                 2155                 2160             


Asp Leu  Leu Pro Pro Gly Gly  Gln Glu Glu Pro Pro  Ser Pro Arg 
    2165                 2170                 2175             


Asp Leu  Lys Lys Cys Tyr Ser  Val Glu Ala Gln Ser  Cys Gln Arg 
    2180                 2185                 2190             


Arg Pro  Thr Ser Trp Leu Asp  Glu Gln Arg Arg His  Ser Ile Ala 
    2195                 2200                 2205             


Val Ser  Cys Leu Asp Ser Gly  Ser Gln Pro His Leu  Gly Thr Asp 
    2210                 2215                 2220             


Pro Ser  Asn Leu Gly Gly Gln  Pro Leu Gly Gly Pro  Gly Ser Arg 
    2225                 2230                 2235             


Pro Lys  Lys Lys Leu Ser Pro  Pro Ser Ile Thr Ile  Asp Pro Pro 
    2240                 2245                 2250             


Glu Ser  Gln Gly Pro Arg Thr  Pro Pro Ser Pro Gly  Ile Cys Leu 
    2255                 2260                 2265             


Arg Arg  Arg Ala Pro Ser Ser  Asp Ser Lys Asp Pro  Leu Ala Ser 
    2270                 2275                 2280             


Gly Pro  Pro Asp Ser Met Ala  Ala Ser Pro Ser Pro  Lys Lys Asp 
    2285                 2290                 2295             


Val Leu  Ser Leu Ser Gly Leu  Ser Ser Asp Pro Ala  Asp Leu Asp 
    2300                 2305                 2310             


Pro 
    


<210>  1499
<211>  2347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1H__Homo_sapiens__NP_001005407

<400>  1499

Met Thr Glu Gly Ala Arg Ala Ala Asp Glu Val Arg Val Pro Leu Gly 
1               5                   10                  15      


Ala Pro Pro Pro Gly Pro Ala Ala Leu Val Gly Ala Ser Pro Glu Ser 
            20                  25                  30          


Pro Gly Ala Pro Gly Arg Glu Ala Glu Arg Gly Ser Glu Leu Gly Val 
        35                  40                  45              


Ser Pro Ser Glu Ser Pro Ala Ala Glu Arg Gly Ala Glu Leu Gly Ala 
    50                  55                  60                  


Asp Glu Glu Gln Arg Val Pro Tyr Pro Ala Leu Ala Ala Thr Val Phe 
65                  70                  75                  80  


Phe Cys Leu Gly Gln Thr Thr Arg Pro Arg Ser Trp Cys Leu Arg Leu 
                85                  90                  95      


Val Cys Asn Pro Trp Phe Glu His Val Ser Met Leu Val Ile Met Leu 
            100                 105                 110         


Asn Cys Val Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Val Glu Cys 
        115                 120                 125             


Gly Ser Glu Arg Cys Asn Ile Leu Glu Ala Phe Asp Ala Phe Ile Phe 
    130                 135                 140                 


Ala Phe Phe Ala Val Glu Met Val Ile Lys Met Val Ala Leu Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe 
                165                 170                 175     


Phe Ile Val Val Ala Gly Met Met Glu Tyr Ser Leu Asp Gly His Asn 
            180                 185                 190         


Val Ser Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg Pro Leu Arg 
        195                 200                 205             


Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu 
    210                 215                 220                 


Asp Thr Leu Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val 
225                 230                 235                 240 


Phe Phe Ile Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu 
                245                 250                 255     


Arg Asn Arg Cys Phe Leu Asp Ser Ala Phe Val Arg Asn Asn Asn Leu 
            260                 265                 270         


Thr Phe Leu Arg Pro Tyr Tyr Gln Thr Glu Glu Gly Glu Glu Asn Pro 
        275                 280                 285             


Phe Ile Cys Ser Ser Arg Arg Asp Asn Gly Met Gln Lys Cys Ser His 
    290                 295                 300                 


Ile Pro Gly Arg Arg Glu Leu Arg Met Pro Cys Thr Leu Gly Trp Glu 
305                 310                 315                 320 


Ala Tyr Thr Gln Pro Gln Ala Glu Gly Val Gly Ala Ala Arg Asn Ala 
                325                 330                 335     


Cys Ile Asn Trp Asn Gln Tyr Tyr Asn Val Cys Arg Ser Gly Asp Ser 
            340                 345                 350         


Asn Pro His Asn Gly Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp 
        355                 360                 365             


Ile Ala Ile Phe Gln Val Ile Thr Leu Glu Gly Trp Val Asp Ile Met 
    370                 375                 380                 


Tyr Tyr Val Met Asp Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile 
385                 390                 395                 400 


Leu Leu Ile Ile Val Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val 
                405                 410                 415     


Val Ile Ala Thr Gln Phe Ser Glu Thr Lys Gln Arg Glu Ser Gln Leu 
            420                 425                 430         


Met Arg Glu Gln Arg Ala Arg His Leu Ser Asn Asp Ser Thr Leu Ala 
        435                 440                 445             


Ser Phe Ser Glu Pro Gly Ser Cys Tyr Glu Glu Leu Leu Lys Tyr Val 
    450                 455                 460                 


Gly His Ile Phe Arg Lys Val Lys Arg Arg Ser Leu Arg Leu Tyr Ala 
465                 470                 475                 480 


Arg Trp Gln Ser Arg Trp Arg Lys Lys Val Asp Pro Ser Ala Val Gln 
                485                 490                 495     


Gly Gln Gly Pro Gly His Arg Gln Arg Arg Ala Gly Arg His Thr Ala 
            500                 505                 510         


Ser Val His His Leu Val Tyr His His His His His His His His His 
        515                 520                 525             


Tyr His Phe Ser His Gly Ser Pro Arg Arg Pro Gly Pro Glu Pro Gly 
    530                 535                 540                 


Ala Cys Asp Thr Arg Leu Val Arg Ala Gly Ala Pro Pro Ser Pro Pro 
545                 550                 555                 560 


Ser Pro Gly Arg Gly Pro Pro Asp Ala Glu Ser Val His Ser Ile Tyr 
                565                 570                 575     


His Ala Asp Cys His Ile Glu Gly Pro Gln Glu Arg Ala Arg Val Ala 
            580                 585                 590         


His Ala Ala Ala Thr Ala Ala Ala Ser Leu Arg Leu Ala Thr Gly Leu 
        595                 600                 605             


Gly Thr Met Asn Tyr Pro Thr Ile Leu Pro Ser Gly Val Gly Ser Gly 
    610                 615                 620                 


Lys Gly Ser Thr Ser Pro Gly Pro Lys Gly Lys Trp Ala Gly Gly Pro 
625                 630                 635                 640 


Pro Gly Thr Gly Gly His Gly Pro Leu Ser Leu Asn Ser Pro Asp Pro 
                645                 650                 655     


Tyr Glu Lys Ile Pro His Val Val Gly Glu His Gly Leu Gly Gln Ala 
            660                 665                 670         


Pro Gly His Leu Ser Gly Leu Ser Val Pro Cys Pro Leu Pro Ser Pro 
        675                 680                 685             


Pro Ala Gly Thr Leu Thr Cys Glu Leu Lys Ser Cys Pro Tyr Cys Thr 
    690                 695                 700                 


Arg Ala Leu Glu Asp Pro Glu Gly Glu Leu Ser Gly Ser Glu Ser Gly 
705                 710                 715                 720 


Asp Ser Asp Gly Arg Gly Val Tyr Glu Phe Thr Gln Asp Val Arg His 
                725                 730                 735     


Gly Asp Arg Trp Asp Pro Thr Arg Pro Pro Arg Ala Thr Asp Thr Pro 
            740                 745                 750         


Gly Pro Gly Pro Gly Ser Pro Gln Arg Arg Ala Gln Gln Arg Ala Ala 
        755                 760                 765             


Pro Gly Glu Pro Gly Trp Met Gly Arg Leu Trp Val Thr Phe Ser Gly 
    770                 775                 780                 


Lys Leu Arg Arg Ile Val Asp Ser Lys Tyr Phe Ser Arg Gly Ile Met 
785                 790                 795                 800 


Met Ala Ile Leu Val Asn Thr Leu Ser Met Gly Val Glu Tyr His Glu 
                805                 810                 815     


Gln Pro Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe 
            820                 825                 830         


Thr Ser Met Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Ala Cys Gly 
        835                 840                 845             


Pro Leu Gly Tyr Ile Arg Asn Pro Tyr Asn Ile Phe Asp Gly Ile Ile 
    850                 855                 860                 


Val Val Ile Ser Val Trp Glu Ile Val Gly Gln Ala Asp Gly Gly Leu 
865                 870                 875                 880 


Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu Lys Leu Val Arg 
                885                 890                 895     


Phe Leu Pro Ala Leu Arg Arg Gln Leu Val Val Leu Val Lys Thr Met 
            900                 905                 910         


Asp Asn Val Ala Thr Phe Cys Thr Leu Leu Met Leu Phe Ile Phe Ile 
        915                 920                 925             


Phe Ser Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ser Leu Lys 
    930                 935                 940                 


Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn Phe Asp Ser Leu 
945                 950                 955                 960 


Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp 
                965                 970                 975     


Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Met Thr  Phe Gly Asn Tyr Val  Leu Phe Asn 
        995                 1000                 1005             


Leu Leu  Val Ala Ile Leu Val  Glu Gly Phe Gln Ala  Glu Gly Asp 
    1010                 1015                 1020             


Ala Asn  Arg Ser Asp Thr Asp  Glu Asp Lys Thr Ser  Val His Phe 
    1025                 1030                 1035             


Glu Glu  Asp Phe His Lys Leu  Arg Glu Leu Gln Thr  Thr Glu Leu 
    1040                 1045                 1050             


Lys Met  Cys Ser Leu Ala Val  Thr Pro Asn Gly His  Leu Glu Gly 
    1055                 1060                 1065             


Arg Gly  Ser Leu Ser Pro Pro  Leu Ile Met Cys Thr  Ala Ala Thr 
    1070                 1075                 1080             


Pro Met  Pro Thr Pro Lys Ser  Ser Pro Phe Leu Asp  Ala Ala Pro 
    1085                 1090                 1095             


Ser Leu  Pro Asp Ser Arg Arg  Gly Ser Ser Ser Ser  Gly Asp Pro 
    1100                 1105                 1110             


Pro Leu  Gly Asp Gln Lys Pro  Pro Ala Ser Leu Arg  Ser Ser Pro 
    1115                 1120                 1125             


Cys Ala  Pro Trp Gly Pro Ser  Gly Ala Trp Ser Ser  Arg Arg Ser 
    1130                 1135                 1140             


Ser Trp  Ser Ser Leu Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Gly 
    1145                 1150                 1155             


Gln Cys  Gly Glu Arg Glu Ser  Leu Leu Ser Gly Glu  Gly Lys Gly 
    1160                 1165                 1170             


Ser Thr  Asp Asp Glu Ala Glu  Asp Gly Arg Ala Ala  Pro Gly Pro 
    1175                 1180                 1185             


Arg Ala  Thr Pro Leu Arg Arg  Ala Glu Ser Leu Asp  Pro Arg Pro 
    1190                 1195                 1200             


Leu Arg  Pro Ala Ala Leu Pro  Pro Thr Lys Cys Arg  Asp Arg Asp 
    1205                 1210                 1215             


Gly Gln  Val Val Ala Leu Pro  Ser Asp Phe Phe Leu  Arg Ile Asp 
    1220                 1225                 1230             


Ser His  Arg Glu Asp Ala Ala  Glu Leu Asp Asp Asp  Ser Glu Asp 
    1235                 1240                 1245             


Ser Cys  Cys Leu Arg Leu His  Lys Val Leu Glu Pro  Tyr Lys Pro 
    1250                 1255                 1260             


Gln Trp  Cys Arg Ser Arg Glu  Ala Trp Ala Leu Tyr  Leu Phe Ser 
    1265                 1270                 1275             


Pro Gln  Asn Arg Phe Arg Val  Ser Cys Gln Lys Val  Ile Thr His 
    1280                 1285                 1290             


Lys Met  Phe Asp His Val Val  Leu Val Phe Ile Phe  Leu Asn Cys 
    1295                 1300                 1305             


Val Thr  Ile Ala Leu Glu Arg  Pro Asp Ile Asp Pro  Gly Ser Thr 
    1310                 1315                 1320             


Glu Arg  Val Phe Leu Ser Val  Ser Asn Tyr Ile Phe  Thr Ala Ile 
    1325                 1330                 1335             


Phe Val  Ala Glu Met Met Val  Lys Val Val Ala Leu  Gly Leu Leu 
    1340                 1345                 1350             


Ser Gly  Glu His Ala Tyr Leu  Gln Ser Ser Trp Asn  Leu Leu Asp 
    1355                 1360                 1365             


Gly Leu  Leu Val Leu Val Ser  Leu Val Asp Ile Val  Val Ala Met 
    1370                 1375                 1380             


Ala Ser  Ala Gly Gly Ala Lys  Ile Leu Gly Val Leu  Arg Val Leu 
    1385                 1390                 1395             


Arg Leu  Leu Arg Thr Leu Arg  Pro Leu Arg Val Ile  Ser Arg Ala 
    1400                 1405                 1410             


Pro Gly  Leu Lys Leu Val Val  Glu Thr Leu Ile Ser  Ser Leu Arg 
    1415                 1420                 1425             


Pro Ile  Gly Asn Ile Val Leu  Ile Cys Cys Ala Phe  Phe Ile Ile 
    1430                 1435                 1440             


Phe Gly  Ile Leu Gly Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Tyr 
    1445                 1450                 1455             


Cys Glu  Gly Pro Asp Thr Arg  Asn Ile Ser Thr Lys  Ala Gln Cys 
    1460                 1465                 1470             


Arg Ala  Ala His Tyr Arg Trp  Val Arg Arg Lys Tyr  Asn Phe Asp 
    1475                 1480                 1485             


Asn Leu  Gly Gln Ala Leu Met  Ser Leu Phe Val Leu  Ser Ser Lys 
    1490                 1495                 1500             


Asp Gly  Trp Val Asn Ile Met  Tyr Asp Gly Leu Asp  Ala Val Gly 
    1505                 1510                 1515             


Val Asp  Gln Gln Pro Val Gln  Asn His Asn Pro Trp  Met Leu Leu 
    1520                 1525                 1530             


Tyr Phe  Ile Ser Phe Leu Leu  Ile Val Ser Phe Phe  Val Leu Asn 
    1535                 1540                 1545             


Met Phe  Val Gly Val Val Val  Glu Asn Phe His Lys  Cys Arg Gln 
    1550                 1555                 1560             


His Gln  Glu Ala Glu Glu Ala  Arg Arg Arg Glu Glu  Lys Arg Leu 
    1565                 1570                 1575             


Arg Arg  Leu Glu Arg Arg Arg  Arg Lys Ala Gln Arg  Arg Pro Tyr 
    1580                 1585                 1590             


Tyr Ala  Asp Tyr Ser Pro Thr  Arg Arg Ser Ile His  Ser Leu Cys 
    1595                 1600                 1605             


Thr Ser  His Tyr Leu Asp Leu  Phe Ile Thr Phe Ile  Ile Cys Val 
    1610                 1615                 1620             


Asn Val  Ile Thr Met Ser Met  Glu His Tyr Asn Gln  Pro Lys Ser 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Tyr  Cys Asn Tyr Val Phe  Thr Ile Val 
    1640                 1645                 1650             


Phe Val  Phe Glu Ala Ala Leu  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Lys Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Leu Met Gly Ile  Thr Leu Glu Glu Ile  Glu Met Ser 
    1685                 1690                 1695             


Ala Ala  Leu Pro Ile Asn Pro  Thr Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Thr Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Thr  Val Val Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Tyr Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Arg Leu Glu Cys  Ser Glu Asp 
    1760                 1765                 1770             


Asn Pro  Cys Glu Gly Leu Ser  Arg His Ala Thr Phe  Ser Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Thr Leu  Phe Arg Val Ser Thr  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Thr Leu Arg Glu Cys  Ser Arg Glu 
    1805                 1810                 1815             


Asp Lys  His Cys Leu Ser Tyr  Leu Pro Ala Leu Ser  Pro Val Tyr 
    1820                 1825                 1830             


Phe Val  Thr Phe Val Leu Val  Ala Gln Phe Val Leu  Val Asn Val 
    1835                 1840                 1845             


Val Val  Ala Val Leu Met Lys  His Leu Glu Glu Ser  Asn Lys Glu 
    1850                 1855                 1860             


Ala Arg  Glu Asp Ala Glu Leu  Asp Ala Glu Ile Glu  Leu Glu Met 
    1865                 1870                 1875             


Ala Gln  Gly Pro Gly Ser Ala  Arg Arg Val Asp Ala  Asp Arg Pro 
    1880                 1885                 1890             


Pro Leu  Pro Gln Glu Ser Pro  Gly Ala Arg Asp Ala  Pro Asn Leu 
    1895                 1900                 1905             


Val Ala  Arg Lys Val Ser Val  Ser Arg Met Leu Ser  Leu Pro Asn 
    1910                 1915                 1920             


Asp Ser  Tyr Met Phe Arg Pro  Val Val Pro Ala Ser  Ala Pro His 
    1925                 1930                 1935             


Pro Arg  Pro Leu Gln Glu Val  Glu Met Glu Thr Tyr  Gly Ala Gly 
    1940                 1945                 1950             


Thr Pro  Leu Gly Ser Val Ala  Ser Val His Ser Pro  Pro Ala Glu 
    1955                 1960                 1965             


Ser Cys  Ala Ser Leu Gln Ile  Pro Leu Ala Val Ser  Ser Pro Ala 
    1970                 1975                 1980             


Arg Ser  Gly Glu Pro Leu His  Ala Leu Ser Pro Arg  Gly Thr Ala 
    1985                 1990                 1995             


Arg Ser  Pro Ser Leu Ser Arg  Leu Leu Cys Arg Gln  Glu Ala Val 
    2000                 2005                 2010             


His Thr  Asp Ser Leu Glu Gly  Lys Ile Asp Ser Pro  Arg Asp Thr 
    2015                 2020                 2025             


Leu Asp  Pro Ala Glu Pro Gly  Glu Lys Thr Pro Val  Arg Pro Val 
    2030                 2035                 2040             


Thr Gln  Gly Gly Ser Leu Gln  Ser Pro Pro Arg Ser  Pro Arg Pro 
    2045                 2050                 2055             


Ala Ser  Val Arg Thr Arg Lys  His Thr Phe Gly Gln  Arg Cys Val 
    2060                 2065                 2070             


Ser Ser  Arg Pro Ala Ala Pro  Gly Gly Glu Glu Ala  Glu Ala Ser 
    2075                 2080                 2085             


Asp Pro  Ala Asp Glu Glu Val  Ser His Ile Thr Ser  Ser Ala Cys 
    2090                 2095                 2100             


Pro Trp  Gln Pro Thr Ala Glu  Pro His Gly Pro Glu  Ala Ser Pro 
    2105                 2110                 2115             


Val Ala  Gly Gly Glu Arg Asp  Leu Arg Arg Leu Tyr  Ser Val Asp 
    2120                 2125                 2130             


Ala Gln  Gly Phe Leu Asp Lys  Pro Gly Arg Ala Asp  Glu Gln Trp 
    2135                 2140                 2145             


Arg Pro  Ser Ala Glu Leu Gly  Ser Gly Glu Pro Gly  Glu Ala Lys 
    2150                 2155                 2160             


Ala Trp  Gly Pro Glu Ala Glu  Pro Ala Leu Gly Ala  Arg Arg Lys 
    2165                 2170                 2175             


Lys Lys  Met Ser Pro Pro Cys  Ile Ser Val Glu Pro  Pro Ala Glu 
    2180                 2185                 2190             


Asp Glu  Gly Ser Ala Arg Pro  Ser Ala Ala Glu Gly  Gly Ser Thr 
    2195                 2200                 2205             


Thr Leu  Arg Arg Arg Thr Pro  Ser Cys Glu Ala Thr  Pro His Arg 
    2210                 2215                 2220             


Asp Ser  Leu Glu Pro Thr Glu  Gly Ser Gly Ala Gly  Gly Asp Pro 
    2225                 2230                 2235             


Ala Ala  Lys Gly Glu Arg Trp  Gly Gln Ala Ser Cys  Arg Ala Glu 
    2240                 2245                 2250             


His Leu  Thr Val Pro Ser Phe  Ala Phe Glu Pro Leu  Asp Leu Gly 
    2255                 2260                 2265             


Val Pro  Ser Gly Asp Pro Phe  Leu Asp Gly Ser His  Ser Val Thr 
    2270                 2275                 2280             


Pro Glu  Ser Arg Ala Ser Ser  Ser Gly Ala Ile Val  Pro Leu Glu 
    2285                 2290                 2295             


Pro Pro  Glu Ser Glu Pro Pro  Met Pro Val Gly Asp  Pro Pro Glu 
    2300                 2305                 2310             


Lys Arg  Arg Gly Leu Tyr Leu  Thr Val Pro Gln Cys  Pro Leu Glu 
    2315                 2320                 2325             


Lys Pro  Gly Ser Pro Ser Ala  Thr Pro Ala Pro Gly  Gly Gly Ala 
    2330                 2335                 2340             


Asp Asp  Pro Val 
    2345         


<210>  1500
<211>  2223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1I__Homo_sapiens__NP_066919

<400>  1500

Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Thr Thr Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Thr Thr Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Thr Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Thr Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Thr Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Thr Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Thr Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Thr Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln 
385                 390                 395                 400 


Phe Ser Glu Thr Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Thr Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr His Gly Lys Thr Lys Gly Gln Gly Asp 
                485                 490                 495     


Glu Gly Arg His Leu Gly Ser Arg His Cys Gln Thr Leu His Gly Pro 
            500                 505                 510         


Ala Ser Pro Gly Asn Asp His Ser Gly Arg Glu Leu Cys Pro Gln His 
        515                 520                 525             


Ser Pro Leu Asp Ala Thr Pro His Thr Leu Val Gln Pro Ile Pro Ala 
    530                 535                 540                 


Thr Leu Ala Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp 
545                 550                 555                 560 


Gly Arg Arg Pro Ser Gly Leu Gly Ser Thr Asp Ser Gly Gln Glu Gly 
                565                 570                 575     


Ser Gly Ser Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp 
            580                 585                 590         


Gly Ala Arg Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu 
        595                 600                 605             


Glu Glu Glu Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp 
    610                 615                 620                 


Val Trp Arg Glu Thr Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys 
625                 630                 635                 640 


Tyr Phe Asn Arg Gly Ile Met Met Ala Ile Leu Val Asn Thr Val Ser 
                645                 650                 655     


Met Gly Ile Glu His His Glu Gln Pro Glu Glu Leu Thr Asn Ile Leu 
            660                 665                 670         


Glu Ile Cys Asn Val Val Phe Thr Ser Met Phe Ala Leu Glu Met Ile 
        675                 680                 685             


Leu Lys Leu Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr 
    690                 695                 700                 


Asn Ile Phe Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val 
705                 710                 715                 720 


Gly Gln Ala Asp Gly Gly Leu Ser Val Leu Arg Thr Phe Arg Leu Leu 
                725                 730                 735     


Arg Val Leu Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu 
            740                 745                 750         


Val Val Leu Met Lys Thr Met Asp Asn Val Ala Thr Phe Cys Met Leu 
        755                 760                 765             


Leu Met Leu Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe 
    770                 775                 780                 


Gly Cys Lys Phe Ser Leu Arg Thr Asp Thr Gly Asp Thr Val Pro Asp 
785                 790                 795                 800 


Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala Ile Val Thr Val Phe Gln 
                805                 810                 815     


Ile Leu Thr Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala 
            820                 825                 830         


Ser Thr Ser Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Thr Phe 
        835                 840                 845             


Gly Asn Tyr Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly 
    850                 855                 860                 


Phe Gln Ala Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln 
865                 870                 875                 880 


Ser Ser Ser Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp 
                885                 890                 895     


Ser Ser Gly Asp Pro Lys Leu Cys Pro Ile Pro Met Thr Pro Asn Gly 
            900                 905                 910         


His Leu Asp Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly 
        915                 920                 925             


Ala Ala Gly Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu 
    930                 935                 940                 


Val Ala Leu Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met 
945                 950                 955                 960 


Ser Tyr Asp Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly 
                965                 970                 975     


Pro Trp Gly Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn 
            980                 985                 990         


Ser Leu Lys His Lys Pro Pro Ser  Ala Glu His Glu Ser  Leu Leu Ser 
        995                 1000                 1005             


Ala Glu  Arg Gly Gly Gly Ala  Arg Val Cys Glu Val  Ala Ala Asp 
    1010                 1015                 1020             


Glu Gly  Pro Pro Arg Ala Ala  Pro Leu His Thr Pro  His Ala His 
    1025                 1030                 1035             


His Ile  His His Gly Pro His  Leu Ala His Arg His  Arg His His 
    1040                 1045                 1050             


Arg Arg  Thr Leu Ser Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala 
    1055                 1060                 1065             


Glu Leu  Val Pro Ala Val Gly  Ala His Pro Arg Ala  Ala Trp Arg 
    1070                 1075                 1080             


Ala Ala  Gly Pro Ala Pro Gly  His Glu Asp Cys Asn  Gly Arg Met 
    1085                 1090                 1095             


Pro Ser  Ile Ala Lys Asp Val  Phe Thr Lys Met Gly  Asp Arg Gly 
    1100                 1105                 1110             


Asp Arg  Gly Glu Asp Glu Glu  Glu Ile Asp Tyr Thr  Leu Cys Phe 
    1115                 1120                 1125             


Arg Val  Arg Lys Met Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu 
    1130                 1135                 1140             


Val Arg  Glu Asp Trp Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg 
    1145                 1150                 1155             


Phe Arg  Val Leu Cys Gln Thr  Ile Ile Ala His Lys  Leu Phe Asp 
    1160                 1165                 1170             


Tyr Val  Val Leu Ala Phe Ile  Phe Leu Asn Cys Ile  Thr Ile Ala 
    1175                 1180                 1185             


Leu Glu  Arg Pro Gln Ile Glu  Ala Gly Ser Thr Glu  Arg Ile Phe 
    1190                 1195                 1200             


Leu Thr  Val Ser Asn Tyr Ile  Phe Thr Ala Ile Phe  Val Gly Glu 
    1205                 1210                 1215             


Met Thr  Leu Lys Val Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln 
    1220                 1225                 1230             


Ala Tyr  Leu Arg Ser Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val 
    1235                 1240                 1245             


Phe Val  Ser Ile Ile Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly 
    1250                 1255                 1260             


Gly Ala  Lys Ile Leu Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg 
    1265                 1270                 1275             


Thr Leu  Arg Pro Leu Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys 
    1280                 1285                 1290             


Leu Val  Val Glu Thr Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn 
    1295                 1300                 1305             


Ile Val  Leu Ile Cys Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu 
    1310                 1315                 1320             


Gly Val  Gln Leu Phe Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val 
    1325                 1330                 1335             


Asp Thr  Arg Asn Ile Thr Asn  Arg Ser Asp Cys Met  Ala Ala Asn 
    1340                 1345                 1350             


Tyr Arg  Trp Val His His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln 
    1355                 1360                 1365             


Ala Leu  Met Ser Leu Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val 
    1370                 1375                 1380             


Asn Ile  Met Tyr Asn Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln 
    1385                 1390                 1395             


Pro Val  Thr Asn His Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser 
    1400                 1405                 1410             


Phe Leu  Leu Ile Val Ser Phe  Phe Val Leu Asn Met  Phe Val Gly 
    1415                 1420                 1425             


Val Val  Val Glu Asn Phe His  Lys Cys Arg Gln His  Gln Glu Ala 
    1430                 1435                 1440             


Glu Glu  Ala Arg Arg Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu 
    1445                 1450                 1455             


Lys Lys  Arg Arg Lys Ala Gln  Arg Leu Pro Tyr Tyr  Ala Thr Tyr 
    1460                 1465                 1470             


Cys His  Thr Arg Leu Leu Ile  His Ser Met Cys Thr  Ser His Tyr 
    1475                 1480                 1485             


Leu Asp  Ile Phe Ile Thr Phe  Ile Ile Cys Leu Asn  Val Val Thr 
    1490                 1495                 1500             


Met Ser  Leu Glu His Tyr Asn  Gln Pro Thr Ser Leu  Glu Thr Ala 
    1505                 1510                 1515             


Leu Lys  Tyr Cys Asn Tyr Met  Phe Thr Thr Val Phe  Val Leu Glu 
    1520                 1525                 1530             


Ala Val  Leu Lys Leu Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys 
    1535                 1540                 1545             


Asp Arg  Trp Asn Gln Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val 
    1550                 1555                 1560             


Met Gly  Ile Thr Leu Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro 
    1565                 1570                 1575             


Ile Asn  Pro Thr Ile Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala 
    1580                 1585                 1590             


Arg Val  Leu Lys Leu Leu Lys  Met Ala Thr Gly Met  Arg Ala Leu 
    1595                 1600                 1605             


Leu Asp  Thr Val Val Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly 
    1610                 1615                 1620             


Leu Leu  Phe Met Leu Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val 
    1625                 1630                 1635             


Glu Leu  Phe Gly Lys Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu 
    1640                 1645                 1650             


Gly Met  Ser Arg His Ala Thr  Phe Glu Asn Phe Gly  Met Ala Phe 
    1655                 1660                 1665             


Leu Thr  Leu Phe Gln Val Ser  Thr Gly Asp Asn Trp  Asn Gly Ile 
    1670                 1675                 1680             


Met Lys  Asp Thr Leu Arg Asp  Cys Thr His Asp Glu  Arg Ser Cys 
    1685                 1690                 1695             


Leu Ser  Ser Leu Gln Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe 
    1700                 1705                 1710             


Val Leu  Thr Ala Gln Phe Val  Leu Ile Asn Val Val  Val Ala Val 
    1715                 1720                 1725             


Leu Met  Lys His Leu Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp 
    1730                 1735                 1740             


Ala Glu  Met Asp Ala Glu Leu  Glu Leu Glu Met Ala  His Gly Leu 
    1745                 1750                 1755             


Gly Pro  Gly Pro Arg Leu Pro  Thr Gly Ser Pro Gly  Ala Pro Gly 
    1760                 1765                 1770             


Arg Gly  Pro Gly Gly Ala Gly  Gly Gly Gly Asp Thr  Glu Gly Gly 
    1775                 1780                 1785             


Leu Cys  Arg Arg Cys Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu 
    1790                 1795                 1800             


Asp Ser  Val Ser Leu Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu 
    1805                 1810                 1815             


Thr Ile  Ile Asp Asn Leu Ser  Gly Ser Ile Phe His  His Tyr Ser 
    1820                 1825                 1830             


Ser Pro  Ala Gly Cys Lys Lys  Cys His His Asp Lys  Gln Glu Val 
    1835                 1840                 1845             


Gln Leu  Ala Glu Thr Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser 
    1850                 1855                 1860             


Ser Ser  Ile Leu Leu Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Thr 
    1865                 1870                 1875             


Ala Cys  Pro Pro Gly Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro 
    1880                 1885                 1890             


Pro Glu  Pro Met Arg Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro 
    1895                 1900                 1905             


Leu Ser  Ser Thr Ala Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys 
    1910                 1915                 1920             


Glu Met  Glu Glu Ile Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys 
    1925                 1930                 1935             


His Asp  Ser Ser Gln Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala 
    1940                 1945                 1950             


Ser Ser  Pro Leu Leu Pro Met  Pro Ala Glu Phe Phe  His Pro Ala 
    1955                 1960                 1965             


Val Ser  Ala Ser Gln Lys Gly  Pro Glu Lys Gly Thr  Gly Thr Gly 
    1970                 1975                 1980             


Thr Leu  Pro Lys Ile Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg 
    1985                 1990                 1995             


Ser Pro  Arg Val Asn Cys Thr  Leu Leu Arg Gln Ala  Thr Gly Ser 
    2000                 2005                 2010             


Asp Thr  Ser Leu Asp Ala Ser  Pro Ser Ser Ser Ala  Gly Ser Leu 
    2015                 2020                 2025             


Gln Thr  Thr Leu Glu Asp Ser  Leu Thr Leu Ser Asp  Ser Pro Arg 
    2030                 2035                 2040             


Arg Ala  Leu Gly Pro Pro Ala  Pro Ala Pro Gly Pro  Arg Ala Gly 
    2045                 2050                 2055             


Leu Ser  Pro Ala Ala Arg Arg  Arg Leu Ser Leu Arg  Gly Arg Gly 
    2060                 2065                 2070             


Leu Phe  Ser Leu Arg Gly Leu  Arg Ala His Gln Arg  Ser His Ser 
    2075                 2080                 2085             


Ser Gly  Gly Ser Thr Ser Pro  Gly Cys Thr His His  Asp Ser Met 
    2090                 2095                 2100             


Asp Pro  Ser Asp Glu Glu Gly  Arg Gly Gly Ala Gly  Gly Gly Gly 
    2105                 2110                 2115             


Ala Gly  Ser Glu His Ser Glu  Thr Leu Ser Ser Leu  Ser Leu Thr 
    2120                 2125                 2130             


Ser Leu  Phe Cys Pro Pro Pro  Pro Pro Pro Ala Pro  Gly Leu Thr 
    2135                 2140                 2145             


Pro Ala  Arg Lys Phe Ser Ser  Thr Ser Ser Leu Ala  Ala Pro Gly 
    2150                 2155                 2160             


Arg Pro  His Ala Ala Ala Leu  Ala His Gly Leu Ala  Arg Ser Pro 
    2165                 2170                 2175             


Ser Trp  Ala Ala Asp Arg Ser  Lys Asp Pro Pro Gly  Arg Ala Pro 
    2180                 2185                 2190             


Leu Pro  Met Gly Leu Gly Pro  Leu Ala Pro Pro Pro  Gln Pro Leu 
    2195                 2200                 2205             


Pro Gly  Glu Leu Glu Pro Gly  Asp Ala Ala Ser Lys  Arg Lys Arg 
    2210                 2215                 2220             


<210>  1501
<211>  1873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA1S__Homo_sapiens__NP_000060

<400>  1501

Met Glu Pro Ser Ser Pro Gln Asp Glu Gly Leu Arg Lys Lys Gln Pro 
1               5                   10                  15      


Lys Lys Pro Val Pro Glu Ile Leu Pro Arg Pro Pro Arg Ala Leu Phe 
            20                  25                  30          


Cys Leu Thr Leu Glu Asn Pro Leu Arg Lys Ala Cys Ile Ser Ile Val 
        35                  40                  45              


Glu Trp Lys Pro Phe Glu Thr Ile Ile Leu Leu Thr Ile Phe Ala Asn 
    50                  55                  60                  


Cys Val Ala Leu Ala Val Tyr Leu Pro Met Pro Glu Asp Asp Asn Asn 
65                  70                  75                  80  


Ser Leu Asn Leu Gly Leu Glu Lys Leu Glu Tyr Phe Phe Leu Ile Val 
                85                  90                  95      


Phe Ser Ile Glu Ala Ala Met Lys Ile Ile Ala Tyr Gly Phe Leu Phe 
            100                 105                 110         


His Gln Asp Ala Tyr Leu Arg Ser Gly Trp Asn Val Leu Asp Phe Thr 
        115                 120                 125             


Ile Val Phe Leu Gly Val Phe Thr Val Ile Leu Glu Gln Val Asn Val 
    130                 135                 140                 


Ile Gln Ser His Thr Ala Pro Met Ser Ser Lys Gly Ala Gly Leu Asp 
145                 150                 155                 160 


Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val 
                165                 170                 175     


Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile Phe Lys Ala 
            180                 185                 190         


Met Leu Pro Leu Phe His Ile Ala Leu Leu Val Leu Phe Met Val Ile 
        195                 200                 205             


Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Lys Gly Lys Met His Lys 
    210                 215                 220                 


Thr Cys Tyr Phe Ile Gly Thr Asp Ile Val Ala Thr Val Glu Asn Glu 
225                 230                 235                 240 


Glu Pro Ser Pro Cys Ala Arg Thr Gly Ser Gly Arg Arg Cys Thr Ile 
                245                 250                 255     


Asn Gly Ser Glu Cys Arg Gly Gly Trp Pro Gly Pro Asn His Gly Ile 
            260                 265                 270         


Thr His Phe Asp Asn Phe Gly Phe Ser Met Leu Thr Val Tyr Gln Cys 
        275                 280                 285             


Ile Thr Met Glu Gly Trp Thr Asp Val Leu Tyr Trp Val Asn Asp Ala 
    290                 295                 300                 


Ile Gly Asn Glu Trp Pro Trp Ile Tyr Phe Val Thr Leu Ile Leu Leu 
305                 310                 315                 320 


Gly Ser Phe Phe Ile Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu 
                325                 330                 335     


Phe Thr Lys Glu Arg Glu Lys Ala Lys Ser Arg Gly Thr Phe Gln Lys 
            340                 345                 350         


Leu Arg Glu Lys Gln Gln Leu Asp Glu Asp Leu Arg Gly Tyr Met Ser 
        355                 360                 365             


Trp Ile Thr Gln Gly Glu Val Met Asp Val Glu Asp Phe Arg Glu Gly 
    370                 375                 380                 


Lys Leu Ser Leu Asp Glu Gly Gly Ser Asp Thr Glu Ser Leu Tyr Glu 
385                 390                 395                 400 


Ile Ala Gly Leu Asn Lys Ile Ile Gln Phe Ile Arg His Trp Arg Gln 
                405                 410                 415     


Trp Asn Arg Ile Phe Arg Trp Lys Cys His Asp Ile Val Lys Ser Lys 
            420                 425                 430         


Val Phe Tyr Trp Leu Val Ile Leu Ile Val Ala Leu Asn Thr Leu Ser 
        435                 440                 445             


Ile Ala Ser Glu His His Asn Gln Pro Leu Trp Leu Thr Arg Leu Gln 
    450                 455                 460                 


Asp Ile Ala Asn Arg Val Leu Leu Ser Leu Phe Thr Thr Glu Met Leu 
465                 470                 475                 480 


Met Lys Met Tyr Gly Leu Gly Leu Arg Gln Tyr Phe Met Ser Ile Phe 
                485                 490                 495     


Asn Arg Phe Asp Cys Phe Val Val Cys Ser Gly Ile Leu Glu Ile Leu 
            500                 505                 510         


Leu Val Glu Ser Gly Ala Met Thr Pro Leu Gly Ile Ser Val Leu Arg 
        515                 520                 525             


Cys Ile Arg Leu Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Thr Ser 
    530                 535                 540                 


Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Ile Arg Ser Ile Ala 
545                 550                 555                 560 


Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Val Ile Phe Ala Leu Leu 
                565                 570                 575     


Gly Met Gln Leu Phe Gly Gly Arg Tyr Asp Phe Glu Asp Thr Glu Val 
            580                 585                 590         


Arg Arg Ser Asn Phe Asp Asn Phe Pro Gln Ala Leu Ile Ser Val Phe 
        595                 600                 605             


Gln Val Leu Thr Gly Glu Asp Trp Thr Ser Met Met Tyr Asn Gly Ile 
    610                 615                 620                 


Met Ala Tyr Gly Gly Pro Ser Tyr Pro Gly Met Leu Val Cys Ile Tyr 
625                 630                 635                 640 


Phe Ile Ile Leu Phe Val Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe 
                645                 650                 655     


Leu Ala Ile Ala Val Asp Asn Leu Ala Glu Ala Glu Ser Leu Thr Ser 
            660                 665                 670         


Ala Gln Lys Ala Lys Ala Glu Glu Lys Lys Arg Arg Lys Met Ser Lys 
        675                 680                 685             


Gly Leu Pro Asp Lys Ser Glu Glu Glu Lys Ser Thr Met Ala Lys Lys 
    690                 695                 700                 


Leu Glu Gln Lys Pro Lys Gly Glu Gly Ile Pro Thr Thr Ala Lys Leu 
705                 710                 715                 720 


Lys Ile Asp Glu Phe Glu Ser Asn Val Asn Glu Val Lys Asp Pro Tyr 
                725                 730                 735     


Pro Ser Ala Asp Phe Pro Gly Asp Asp Glu Glu Asp Glu Pro Glu Ile 
            740                 745                 750         


Pro Leu Ser Pro Arg Pro Arg Pro Leu Ala Glu Leu Gln Leu Lys Glu 
        755                 760                 765             


Lys Ala Val Pro Ile Pro Glu Ala Ser Ser Phe Phe Ile Phe Ser Pro 
    770                 775                 780                 


Thr Asn Lys Ile Arg Val Leu Cys His Arg Ile Val Asn Ala Thr Trp 
785                 790                 795                 800 


Phe Thr Asn Phe Ile Leu Leu Phe Ile Leu Leu Ser Ser Ala Ala Leu 
                805                 810                 815     


Ala Ala Glu Asp Pro Ile Arg Ala Asp Ser Met Arg Asn Gln Ile Leu 
            820                 825                 830         


Lys His Phe Asp Ile Gly Phe Thr Ser Val Phe Thr Val Glu Ile Val 
        835                 840                 845             


Leu Lys Met Thr Thr Tyr Gly Ala Phe Leu His Lys Gly Ser Phe Cys 
    850                 855                 860                 


Arg Asn Tyr Phe Asn Met Leu Asp Leu Leu Val Val Ala Val Ser Leu 
865                 870                 875                 880 


Ile Ser Met Gly Leu Glu Ser Ser Ala Ile Ser Val Val Lys Ile Leu 
                885                 890                 895     


Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys 
            900                 905                 910         


Gly Leu Lys His Val Val Gln Cys Met Phe Val Ala Ile Ser Thr Ile 
        915                 920                 925             


Gly Asn Ile Val Leu Val Thr Thr Leu Leu Gln Phe Met Phe Ala Cys 
    930                 935                 940                 


Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Phe Arg Cys Thr Asp Leu 
945                 950                 955                 960 


Ser Lys Met Thr Glu Glu Glu Cys Arg Gly Tyr Tyr Tyr Val Tyr Lys 
                965                 970                 975     


Asp Gly Asp Pro Met Gln Ile Glu Leu Arg His Arg Glu Trp Val His 
            980                 985                 990         


Ser Asp Phe His Phe Asp Asn Val  Leu Ser Ala Met Met  Ser Leu Phe 
        995                 1000                 1005             


Thr Val  Ser Thr Phe Glu Gly  Trp Pro Gln Leu Leu  Tyr Lys Ala 
    1010                 1015                 1020             


Ile Asp  Ser Asn Ala Glu Asp  Val Gly Pro Ile Tyr  Asn Asn Arg 
    1025                 1030                 1035             


Val Glu  Met Ala Ile Phe Phe  Ile Ile Tyr Ile Ile  Leu Ile Ala 
    1040                 1045                 1050             


Phe Phe  Met Met Asn Ile Phe  Val Gly Phe Val Ile  Val Thr Phe 
    1055                 1060                 1065             


Gln Glu  Gln Gly Glu Thr Glu  Tyr Lys Asn Cys Glu  Leu Asp Lys 
    1070                 1075                 1080             


Asn Gln  Arg Gln Cys Val Gln  Tyr Ala Leu Lys Ala  Arg Pro Leu 
    1085                 1090                 1095             


Arg Cys  Tyr Ile Pro Lys Asn  Pro Tyr Gln Tyr Gln  Val Trp Tyr 
    1100                 1105                 1110             


Ile Val  Thr Ser Ser Tyr Phe  Glu Tyr Leu Met Phe  Ala Leu Ile 
    1115                 1120                 1125             


Met Leu  Asn Thr Ile Cys Leu  Gly Met Gln His Tyr  Asn Gln Ser 
    1130                 1135                 1140             


Glu Gln  Met Asn His Ile Ser  Asp Ile Leu Asn Val  Ala Phe Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Glu Met  Ile Leu Lys Leu Met  Ala Phe Lys 
    1160                 1165                 1170             


Ala Arg  Gly Tyr Phe Gly Asp  Pro Trp Asn Val Phe  Asp Phe Leu 
    1175                 1180                 1185             


Ile Val  Ile Gly Ser Ile Ile  Asp Val Ile Leu Ser  Glu Ile Asp 
    1190                 1195                 1200             


Thr Phe  Leu Ala Ser Ser Gly  Gly Leu Tyr Cys Leu  Gly Gly Gly 
    1205                 1210                 1215             


Cys Gly  Asn Val Asp Pro Asp  Glu Ser Ala Arg Ile  Ser Ser Ala 
    1220                 1225                 1230             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Ile Lys  Leu Leu Ser 
    1235                 1240                 1245             


Arg Ala  Glu Gly Val Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1250                 1255                 1260             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe 
    1265                 1270                 1275             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Ile Ala 
    1280                 1285                 1290             


Leu Val  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1295                 1300                 1305             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1310                 1315                 1320             


Ala Trp  Gln Glu Ile Leu Leu  Ala Cys Ser Tyr Gly  Lys Leu Cys 
    1325                 1330                 1335             


Asp Pro  Glu Ser Asp Tyr Ala  Pro Gly Glu Glu Tyr  Thr Cys Gly 
    1340                 1345                 1350             


Thr Asn  Phe Ala Tyr Tyr Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1355                 1360                 1365             


Ala Phe  Leu Val Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1370                 1375                 1380             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1385                 1390                 1395             


Leu Asp  Glu Phe Lys Ala Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala 
    1400                 1405                 1410             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Thr Leu  Leu Arg Arg 
    1415                 1420                 1425             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Phe Cys Pro  His Arg Val 
    1430                 1435                 1440             


Ala Cys  Lys Arg Leu Val Gly  Met Asn Met Pro Leu  Asn Ser Asp 
    1445                 1450                 1455             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1460                 1465                 1470             


Ala Leu  Lys Ile Lys Thr Glu  Gly Asn Phe Glu Gln  Ala Asn Glu 
    1475                 1480                 1485             


Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp Lys Arg  Thr Ser Met 
    1490                 1495                 1500             


Lys Leu  Leu Asp Gln Val Ile  Pro Pro Ile Gly Asp  Asp Glu Val 
    1505                 1510                 1515             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Glu His Phe 
    1520                 1525                 1530             


Arg Lys  Phe Met Lys Arg Gln  Glu Glu Tyr Tyr Gly  Tyr Arg Pro 
    1535                 1540                 1545             


Lys Lys  Asp Ile Val Gln Ile  Gln Ala Gly Leu Arg  Thr Ile Glu 
    1550                 1555                 1560             


Glu Glu  Ala Ala Pro Glu Ile  Cys Arg Thr Val Ser  Gly Asp Leu 
    1565                 1570                 1575             


Ala Ala  Glu Glu Glu Leu Glu  Arg Ala Met Val Glu  Ala Ala Met 
    1580                 1585                 1590             


Glu Glu  Gly Ile Phe Arg Arg  Thr Gly Gly Leu Phe  Gly Gln Val 
    1595                 1600                 1605             


Asp Asn  Phe Leu Glu Arg Thr  Asn Ser Leu Pro Pro  Val Met Ala 
    1610                 1615                 1620             


Asn Gln  Arg Pro Leu Gln Phe  Ala Glu Ile Glu Met  Glu Glu Met 
    1625                 1630                 1635             


Glu Ser  Pro Val Phe Leu Glu  Asp Phe Pro Gln Asp  Pro Arg Thr 
    1640                 1645                 1650             


Asn Pro  Leu Ala Arg Ala Asn  Thr Asn Asn Ala Asn  Ala Asn Val 
    1655                 1660                 1665             


Ala Tyr  Gly Asn Ser Asn His  Ser Asn Ser His Val  Phe Ser Ser 
    1670                 1675                 1680             


Val His  Tyr Glu Arg Glu Phe  Pro Glu Glu Thr Glu  Thr Pro Ala 
    1685                 1690                 1695             


Thr Arg  Gly Arg Ala Leu Gly  Gln Pro Cys Arg Val  Leu Gly Pro 
    1700                 1705                 1710             


His Ser  Lys Pro Cys Val Glu  Met Leu Lys Gly Leu  Leu Thr Gln 
    1715                 1720                 1725             


Arg Ala  Met Pro Arg Gly Gln  Ala Pro Pro Ala Pro  Cys Gln Cys 
    1730                 1735                 1740             


Pro Arg  Val Glu Ser Ser Met  Pro Glu Asp Arg Lys  Ser Ser Thr 
    1745                 1750                 1755             


Pro Gly  Ser Leu His Glu Glu  Thr Pro His Ser Arg  Ser Thr Arg 
    1760                 1765                 1770             


Glu Asn  Thr Ser Arg Cys Ser  Ala Pro Ala Thr Ala  Leu Leu Ile 
    1775                 1780                 1785             


Gln Lys  Ala Leu Val Arg Gly  Gly Leu Gly Thr Leu  Ala Ala Asp 
    1790                 1795                 1800             


Ala Asn  Phe Ile Met Ala Thr  Gly Gln Ala Leu Ala  Asp Ala Cys 
    1805                 1810                 1815             


Gln Met  Glu Pro Glu Glu Val  Glu Ile Met Ala Thr  Glu Leu Leu 
    1820                 1825                 1830             


Lys Gly  Arg Glu Ala Pro Glu  Gly Met Ala Ser Ser  Leu Gly Cys 
    1835                 1840                 1845             


Leu Asn  Leu Gly Ser Ser Leu  Gly Ser Leu Asp Gln  His Gln Gly 
    1850                 1855                 1860             


Ser Gln  Glu Thr Leu Ile Pro  Pro Arg Leu 
    1865                 1870             


<210>  1502
<211>  1091
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA2D1__Homo_sapiens__NP_000713

<400>  1502

Met Ala Ala Gly Cys Leu Leu Ala Leu Thr Leu Thr Leu Phe Gln Ser 
1               5                   10                  15      


Leu Leu Ile Gly Pro Ser Ser Glu Glu Pro Phe Pro Ser Ala Val Thr 
            20                  25                  30          


Ile Lys Ser Trp Val Asp Lys Met Gln Glu Asp Leu Val Thr Leu Ala 
        35                  40                  45              


Lys Thr Ala Ser Gly Val Asn Gln Leu Val Asp Ile Tyr Glu Lys Tyr 
    50                  55                  60                  


Gln Asp Leu Tyr Thr Val Glu Pro Asn Asn Ala Arg Gln Leu Val Glu 
65                  70                  75                  80  


Ile Ala Ala Arg Asp Ile Glu Lys Leu Leu Ser Asn Arg Ser Lys Ala 
                85                  90                  95      


Leu Val Arg Leu Ala Leu Glu Ala Glu Lys Val Gln Ala Ala His Gln 
            100                 105                 110         


Trp Arg Glu Asp Phe Ala Ser Asn Glu Val Val Tyr Tyr Asn Ala Lys 
        115                 120                 125             


Asp Asp Leu Asp Pro Glu Lys Asn Asp Ser Glu Pro Gly Ser Gln Arg 
    130                 135                 140                 


Ile Lys Pro Val Phe Ile Glu Asp Ala Asn Phe Gly Arg Gln Ile Ser 
145                 150                 155                 160 


Tyr Gln His Ala Ala Val His Ile Pro Thr Asp Ile Tyr Glu Gly Ser 
                165                 170                 175     


Thr Ile Val Leu Asn Glu Leu Asn Trp Thr Ser Ala Leu Asp Glu Val 
            180                 185                 190         


Phe Lys Lys Asn Arg Glu Glu Asp Pro Ser Leu Leu Trp Gln Val Phe 
        195                 200                 205             


Gly Ser Ala Thr Gly Leu Ala Arg Tyr Tyr Pro Ala Ser Pro Trp Val 
    210                 215                 220                 


Asp Asn Ser Arg Thr Pro Asn Lys Ile Asp Leu Tyr Asp Val Arg Arg 
225                 230                 235                 240 


Arg Pro Trp Tyr Ile Gln Gly Ala Ala Ser Pro Lys Asp Met Leu Ile 
                245                 250                 255     


Leu Val Asp Val Ser Gly Ser Val Ser Gly Leu Thr Leu Lys Leu Ile 
            260                 265                 270         


Arg Thr Ser Val Ser Glu Met Leu Glu Thr Leu Ser Asp Asp Asp Phe 
        275                 280                 285             


Val Asn Val Ala Ser Phe Asn Ser Asn Ala Gln Asp Val Ser Cys Phe 
    290                 295                 300                 


Gln His Leu Val Gln Ala Asn Val Arg Asn Lys Lys Val Leu Lys Asp 
305                 310                 315                 320 


Ala Val Asn Asn Ile Thr Ala Lys Gly Ile Thr Asp Tyr Lys Lys Gly 
                325                 330                 335     


Phe Ser Phe Ala Phe Glu Gln Leu Leu Asn Tyr Asn Val Ser Arg Ala 
            340                 345                 350         


Asn Cys Asn Lys Ile Ile Met Leu Phe Thr Asp Gly Gly Glu Glu Arg 
        355                 360                 365             


Ala Gln Glu Ile Phe Asn Lys Tyr Asn Lys Asp Lys Lys Val Arg Val 
    370                 375                 380                 


Phe Thr Phe Ser Val Gly Gln His Asn Tyr Asp Arg Gly Pro Ile Gln 
385                 390                 395                 400 


Trp Met Ala Cys Glu Asn Lys Gly Tyr Tyr Tyr Glu Ile Pro Ser Ile 
                405                 410                 415     


Gly Ala Ile Arg Ile Asn Thr Gln Glu Tyr Leu Asp Val Leu Gly Arg 
            420                 425                 430         


Pro Met Val Leu Ala Gly Asp Lys Ala Lys Gln Val Gln Trp Thr Asn 
        435                 440                 445             


Val Tyr Leu Asp Ala Leu Glu Leu Gly Leu Val Ile Thr Gly Thr Leu 
    450                 455                 460                 


Pro Val Phe Asn Ile Thr Gly Gln Phe Glu Asn Lys Thr Asn Leu Lys 
465                 470                 475                 480 


Asn Gln Leu Ile Leu Gly Val Met Gly Val Asp Val Ser Leu Glu Asp 
                485                 490                 495     


Ile Lys Arg Leu Thr Pro Arg Phe Thr Leu Cys Pro Asn Gly Tyr Tyr 
            500                 505                 510         


Phe Ala Ile Asp Pro Asn Gly Tyr Val Leu Leu His Pro Asn Leu Gln 
        515                 520                 525             


Pro Lys Asn Pro Lys Ser Gln Glu Pro Val Thr Leu Asp Phe Leu Asp 
    530                 535                 540                 


Ala Glu Leu Glu Asn Asp Ile Lys Val Glu Ile Arg Asn Lys Met Ile 
545                 550                 555                 560 


Asp Gly Glu Ser Gly Glu Lys Thr Phe Arg Thr Leu Val Lys Ser Gln 
                565                 570                 575     


Asp Glu Arg Tyr Ile Asp Lys Gly Asn Arg Thr Tyr Thr Trp Thr Pro 
            580                 585                 590         


Val Asn Gly Thr Asp Tyr Ser Leu Ala Leu Val Leu Pro Thr Tyr Ser 
        595                 600                 605             


Phe Tyr Tyr Ile Lys Ala Lys Leu Glu Glu Thr Ile Thr Gln Ala Arg 
    610                 615                 620                 


Ser Lys Lys Gly Lys Met Lys Asp Ser Glu Thr Leu Lys Pro Asp Asn 
625                 630                 635                 640 


Phe Glu Glu Ser Gly Tyr Thr Phe Ile Ala Pro Arg Asp Tyr Cys Asn 
                645                 650                 655     


Asp Leu Lys Ile Ser Asp Asn Asn Thr Glu Phe Leu Leu Asn Phe Asn 
            660                 665                 670         


Glu Phe Ile Asp Arg Lys Thr Pro Asn Asn Pro Ser Cys Asn Ala Asp 
        675                 680                 685             


Leu Ile Asn Arg Val Leu Leu Asp Ala Gly Phe Thr Asn Glu Leu Val 
    690                 695                 700                 


Gln Asn Tyr Trp Ser Lys Gln Lys Asn Ile Lys Gly Val Lys Ala Arg 
705                 710                 715                 720 


Phe Val Val Thr Asp Gly Gly Ile Thr Arg Val Tyr Pro Lys Glu Ala 
                725                 730                 735     


Gly Glu Asn Trp Gln Glu Asn Pro Glu Thr Tyr Glu Asp Ser Phe Tyr 
            740                 745                 750         


Lys Arg Ser Leu Asp Asn Asp Asn Tyr Val Phe Thr Ala Pro Tyr Phe 
        755                 760                 765             


Asn Lys Ser Gly Pro Gly Ala Tyr Glu Ser Gly Ile Met Val Ser Lys 
    770                 775                 780                 


Ala Val Glu Ile Tyr Ile Gln Gly Lys Leu Leu Lys Pro Ala Val Val 
785                 790                 795                 800 


Gly Ile Lys Ile Asp Val Asn Ser Trp Ile Glu Asn Phe Thr Lys Thr 
                805                 810                 815     


Ser Ile Arg Asp Pro Cys Ala Gly Pro Val Cys Asp Cys Lys Arg Asn 
            820                 825                 830         


Ser Asp Val Met Asp Cys Val Ile Leu Asp Asp Gly Gly Phe Leu Leu 
        835                 840                 845             


Met Ala Asn His Asp Asp Tyr Thr Asn Gln Ile Gly Arg Phe Phe Gly 
    850                 855                 860                 


Glu Ile Asp Pro Ser Leu Met Arg His Leu Val Asn Ile Ser Val Tyr 
865                 870                 875                 880 


Ala Phe Asn Lys Ser Tyr Asp Tyr Gln Ser Val Cys Glu Pro Gly Ala 
                885                 890                 895     


Ala Pro Lys Gln Gly Ala Gly His Arg Ser Ala Tyr Val Pro Ser Val 
            900                 905                 910         


Ala Asp Ile Leu Gln Ile Gly Trp Trp Ala Thr Ala Ala Ala Trp Ser 
        915                 920                 925             


Ile Leu Gln Gln Phe Leu Leu Ser Leu Thr Phe Pro Arg Leu Leu Glu 
    930                 935                 940                 


Ala Val Glu Met Glu Asp Asp Asp Phe Thr Ala Ser Leu Ser Lys Gln 
945                 950                 955                 960 


Ser Cys Ile Thr Glu Gln Thr Gln Tyr Phe Phe Asp Asn Asp Ser Lys 
                965                 970                 975     


Ser Phe Ser Gly Val Leu Asp Cys Gly Asn Cys Ser Arg Ile Phe His 
            980                 985                 990         


Gly Glu Lys Leu Met Asn Thr Asn  Leu Ile Phe Ile Met  Val Glu Ser 
        995                 1000                 1005             


Lys Gly  Thr Cys Pro Cys Asp  Thr Arg Leu Leu Ile  Gln Ala Glu 
    1010                 1015                 1020             


Gln Thr  Ser Asp Gly Pro Asn  Pro Cys Asp Met Val  Lys Gln Pro 
    1025                 1030                 1035             


Arg Tyr  Arg Lys Gly Pro Asp  Val Cys Phe Asp Asn  Asn Val Leu 
    1040                 1045                 1050             


Glu Asp  Tyr Thr Asp Cys Gly  Gly Val Ser Gly Leu  Asn Pro Ser 
    1055                 1060                 1065             


Leu Trp  Tyr Ile Ile Gly Ile  Gln Phe Leu Leu Leu  Trp Leu Val 
    1070                 1075                 1080             


Ser Gly  Ser Thr His Arg Leu  Leu 
    1085                 1090     


<210>  1503
<211>  1145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA2D2__Homo_sapiens__NP_001005505

<400>  1503

Met Ala Val Pro Ala Arg Thr Cys Gly Ala Ser Arg Pro Gly Pro Ala 
1               5                   10                  15      


Arg Thr Ala Arg Pro Trp Pro Gly Cys Gly Pro His Pro Gly Pro Gly 
            20                  25                  30          


Thr Arg Arg Pro Thr Ser Gly Pro Pro Arg Pro Leu Trp Leu Leu Leu 
        35                  40                  45              


Pro Leu Leu Pro Leu Leu Ala Ala Pro Gly Ala Ser Ala Tyr Ser Phe 
    50                  55                  60                  


Pro Gln Gln His Thr Met Gln His Trp Ala Arg Arg Leu Glu Gln Glu 
65                  70                  75                  80  


Val Asp Gly Val Met Arg Ile Phe Gly Gly Val Gln Gln Leu Arg Glu 
                85                  90                  95      


Ile Tyr Lys Asp Asn Arg Asn Leu Phe Glu Val Gln Glu Asn Glu Pro 
            100                 105                 110         


Gln Lys Leu Val Glu Lys Val Ala Gly Asp Ile Glu Ser Leu Leu Asp 
        115                 120                 125             


Arg Lys Val Gln Ala Leu Lys Arg Leu Ala Asp Ala Ala Glu Asn Phe 
    130                 135                 140                 


Gln Lys Ala His Arg Trp Gln Asp Asn Ile Lys Glu Glu Asp Ile Val 
145                 150                 155                 160 


Tyr Tyr Asp Ala Lys Ala Asp Ala Glu Leu Asp Asp Pro Glu Ser Glu 
                165                 170                 175     


Asp Val Glu Arg Gly Ser Lys Ala Ser Thr Leu Arg Leu Asp Phe Ile 
            180                 185                 190         


Glu Asp Pro Asn Phe Lys Asn Lys Val Asn Tyr Ser Tyr Ala Ala Val 
        195                 200                 205             


Gln Ile Pro Thr Asp Ile Tyr Lys Gly Ser Thr Val Ile Leu Asn Glu 
    210                 215                 220                 


Leu Asn Trp Thr Glu Ala Leu Glu Asn Val Phe Met Glu Asn Arg Arg 
225                 230                 235                 240 


Gln Asp Pro Thr Leu Leu Trp Gln Val Phe Gly Ser Ala Thr Gly Val 
                245                 250                 255     


Thr Arg Tyr Tyr Pro Ala Thr Pro Trp Arg Ala Pro Lys Lys Ile Asp 
            260                 265                 270         


Leu Tyr Asp Val Arg Arg Arg Pro Trp Tyr Ile Gln Gly Ala Ser Ser 
        275                 280                 285             


Pro Lys Asp Met Val Ile Ile Val Asp Val Ser Gly Ser Val Ser Gly 
    290                 295                 300                 


Leu Thr Leu Lys Leu Met Lys Thr Ser Val Cys Glu Met Leu Asp Thr 
305                 310                 315                 320 


Leu Ser Asp Asp Asp Tyr Val Asn Val Ala Ser Phe Asn Glu Lys Ala 
                325                 330                 335     


Gln Pro Val Ser Cys Phe Thr His Leu Val Gln Ala Asn Val Arg Asn 
            340                 345                 350         


Lys Lys Val Phe Lys Glu Ala Val Gln Gly Met Val Ala Lys Gly Thr 
        355                 360                 365             


Thr Gly Tyr Lys Ala Gly Phe Glu Tyr Ala Phe Asp Gln Leu Gln Asn 
    370                 375                 380                 


Ser Asn Ile Thr Arg Ala Asn Cys Asn Lys Met Ile Met Met Phe Thr 
385                 390                 395                 400 


Asp Gly Gly Glu Asp Arg Val Gln Asp Val Phe Glu Lys Tyr Asn Trp 
                405                 410                 415     


Pro Asn Arg Thr Val Arg Val Phe Thr Phe Ser Val Gly Gln His Asn 
            420                 425                 430         


Tyr Asp Val Thr Pro Leu Gln Trp Met Ala Cys Ala Asn Lys Gly Tyr 
        435                 440                 445             


Tyr Phe Glu Ile Pro Ser Ile Gly Ala Ile Arg Ile Asn Thr Gln Glu 
    450                 455                 460                 


Tyr Leu Asp Val Leu Gly Arg Pro Met Val Leu Ala Gly Lys Glu Ala 
465                 470                 475                 480 


Lys Gln Val Gln Trp Thr Asn Val Tyr Glu Asp Ala Leu Gly Leu Gly 
                485                 490                 495     


Leu Val Val Thr Gly Thr Leu Pro Val Phe Asn Leu Thr Gln Asp Gly 
            500                 505                 510         


Pro Gly Glu Lys Lys Asn Gln Leu Ile Leu Gly Val Met Gly Ile Asp 
        515                 520                 525             


Val Ala Leu Asn Asp Ile Lys Arg Leu Thr Pro Asn Tyr Thr Leu Gly 
    530                 535                 540                 


Ala Asn Gly Tyr Val Phe Ala Ile Asp Leu Asn Gly Tyr Val Leu Leu 
545                 550                 555                 560 


His Pro Asn Leu Lys Pro Gln Thr Thr Asn Phe Arg Glu Pro Val Thr 
                565                 570                 575     


Leu Asp Phe Leu Asp Ala Glu Leu Glu Asp Glu Asn Lys Glu Glu Ile 
            580                 585                 590         


Arg Arg Ser Met Ile Asp Gly Asn Lys Gly His Lys Gln Ile Arg Thr 
        595                 600                 605             


Leu Val Lys Ser Leu Asp Glu Arg Tyr Ile Asp Glu Val Thr Arg Asn 
    610                 615                 620                 


Tyr Thr Trp Val Pro Ile Arg Ser Thr Asn Tyr Ser Leu Gly Leu Val 
625                 630                 635                 640 


Leu Pro Pro Tyr Ser Thr Phe Tyr Leu Gln Ala Asn Leu Ser Asp Gln 
                645                 650                 655     


Ile Leu Gln Val Lys Tyr Phe Glu Phe Leu Leu Pro Ser Ser Phe Glu 
            660                 665                 670         


Ser Glu Gly His Val Phe Ile Ala Pro Arg Glu Tyr Cys Lys Asp Leu 
        675                 680                 685             


Asn Ala Ser Asp Asn Asn Thr Glu Phe Leu Lys Asn Phe Ile Glu Leu 
    690                 695                 700                 


Met Glu Lys Val Thr Pro Asp Ser Lys Gln Cys Asn Asn Phe Leu Leu 
705                 710                 715                 720 


His Asn Leu Ile Leu Asp Thr Gly Ile Thr Gln Gln Leu Val Glu Arg 
                725                 730                 735     


Val Trp Arg Asp Gln Asp Leu Asn Thr Tyr Ser Leu Leu Ala Val Phe 
            740                 745                 750         


Ala Ala Thr Asp Gly Gly Ile Thr Arg Val Phe Pro Asn Lys Ala Ala 
        755                 760                 765             


Glu Asp Trp Thr Glu Asn Pro Glu Pro Phe Asn Ala Ser Phe Tyr Arg 
    770                 775                 780                 


Arg Ser Leu Asp Asn His Gly Tyr Val Phe Lys Pro Pro His Gln Asp 
785                 790                 795                 800 


Ala Leu Leu Arg Pro Leu Glu Leu Glu Asn Asp Thr Val Gly Ile Leu 
                805                 810                 815     


Val Ser Thr Ala Val Glu Leu Ser Leu Gly Arg Arg Thr Leu Arg Pro 
            820                 825                 830         


Ala Val Val Gly Val Lys Leu Asp Leu Glu Ala Trp Ala Glu Lys Phe 
        835                 840                 845             


Lys Val Leu Ala Ser Asn Arg Thr His Gln Asp Gln Pro Gln Lys Cys 
    850                 855                 860                 


Gly Pro Asn Ser His Cys Glu Met Asp Cys Glu Val Asn Asn Glu Asp 
865                 870                 875                 880 


Leu Leu Cys Val Leu Ile Asp Asp Gly Gly Phe Leu Val Leu Ser Asn 
                885                 890                 895     


Gln Asn His Gln Trp Asp Gln Val Gly Arg Phe Phe Ser Glu Val Asp 
            900                 905                 910         


Ala Asn Leu Met Leu Ala Leu Tyr Asn Asn Ser Phe Tyr Thr Arg Lys 
        915                 920                 925             


Glu Ser Tyr Asp Tyr Gln Ala Ala Cys Ala Pro Gln Pro Pro Gly Asn 
    930                 935                 940                 


Leu Gly Ala Ala Pro Arg Gly Val Phe Val Pro Thr Val Ala Asp Phe 
945                 950                 955                 960 


Leu Asn Leu Ala Trp Trp Thr Ser Ala Ala Ala Trp Ser Leu Phe Gln 
                965                 970                 975     


Gln Leu Leu Tyr Gly Leu Ile Tyr His Ser Trp Phe Gln Ala Asp Pro 
            980                 985                 990         


Ala Glu Ala Glu Gly Ser Pro Glu  Thr Arg Glu Ser Ser  Cys Val Met 
        995                 1000                 1005             


Lys Gln  Thr Gln Tyr Tyr Phe  Gly Ser Val Asn Ala  Ser Tyr Asn 
    1010                 1015                 1020             


Ala Ile  Ile Asp Cys Gly Asn  Cys Ser Arg Leu Phe  His Ala Gln 
    1025                 1030                 1035             


Arg Leu  Thr Asn Thr Asn Leu  Leu Phe Val Val Ala  Glu Lys Pro 
    1040                 1045                 1050             


Leu Cys  Ser Gln Cys Glu Ala  Gly Arg Leu Leu Gln  Lys Glu Thr 
    1055                 1060                 1065             


His Cys  Pro Ala Asp Gly Pro  Glu Gln Cys Glu Leu  Val Gln Arg 
    1070                 1075                 1080             


Pro Arg  Tyr Arg Arg Gly Pro  His Ile Cys Phe Asp  Tyr Asn Ala 
    1085                 1090                 1095             


Thr Glu  Asp Thr Ser Asp Cys  Gly Arg Gly Ala Ser  Phe Pro Pro 
    1100                 1105                 1110             


Ser Leu  Gly Val Leu Val Ser  Leu Gln Leu Leu Leu  Leu Leu Gly 
    1115                 1120                 1125             


Leu Pro  Pro Arg Pro Gln Pro  Gln Val Leu Val His  Ala Ser Arg 
    1130                 1135                 1140             


Arg Leu  
    1145 


<210>  1504
<211>  1091
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA2D3__Homo_sapiens__NP_060868

<400>  1504

Met Ala Gly Pro Gly Ser Pro Arg Arg Ala Ser Arg Gly Ala Ser Ala 
1               5                   10                  15      


Leu Leu Ala Ala Ala Leu Leu Tyr Ala Ala Leu Gly Asp Val Val Arg 
            20                  25                  30          


Ser Glu Gln Gln Ile Pro Leu Ser Val Val Lys Leu Trp Ala Ser Ala 
        35                  40                  45              


Phe Gly Gly Glu Ile Lys Ser Ile Ala Ala Lys Tyr Ser Gly Ser Gln 
    50                  55                  60                  


Leu Leu Gln Lys Lys Tyr Lys Glu Tyr Glu Lys Asp Val Ala Ile Glu 
65                  70                  75                  80  


Glu Ile Asp Gly Leu Gln Leu Val Lys Lys Leu Ala Lys Asn Met Glu 
                85                  90                  95      


Glu Met Phe His Lys Lys Ser Glu Ala Val Arg Arg Leu Val Glu Ala 
            100                 105                 110         


Ala Glu Glu Ala His Leu Lys His Glu Phe Asp Ala Asp Leu Gln Tyr 
        115                 120                 125             


Glu Tyr Phe Asn Ala Val Leu Ile Asn Glu Arg Asp Lys Asp Gly Asn 
    130                 135                 140                 


Phe Leu Glu Leu Gly Lys Glu Phe Ile Leu Ala Pro Asn Asp His Phe 
145                 150                 155                 160 


Asn Asn Leu Pro Val Asn Ile Ser Leu Ser Asp Val Gln Val Pro Thr 
                165                 170                 175     


Asn Met Tyr Asn Lys Asp Pro Ala Ile Val Asn Gly Val Tyr Trp Ser 
            180                 185                 190         


Glu Ser Leu Asn Lys Val Phe Val Asp Asn Phe Asp Arg Asp Pro Ser 
        195                 200                 205             


Leu Ile Trp Gln Tyr Phe Gly Ser Ala Lys Gly Phe Phe Arg Gln Tyr 
    210                 215                 220                 


Pro Gly Ile Lys Trp Glu Pro Asp Glu Asn Gly Val Ile Ala Phe Asp 
225                 230                 235                 240 


Cys Arg Asn Arg Lys Trp Tyr Ile Gln Ala Ala Thr Ser Pro Lys Asp 
                245                 250                 255     


Val Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly Leu Arg Leu 
            260                 265                 270         


Thr Ile Ala Lys Gln Thr Val Ser Ser Ile Leu Asp Thr Leu Gly Asp 
        275                 280                 285             


Asp Asp Phe Phe Asn Ile Ile Ala Tyr Asn Glu Glu Leu His Tyr Val 
    290                 295                 300                 


Glu Pro Cys Leu Asn Gly Thr Leu Val Gln Ala Asp Arg Thr Asn Lys 
305                 310                 315                 320 


Glu His Phe Arg Glu His Leu Asp Lys Leu Phe Ala Lys Gly Ile Gly 
                325                 330                 335     


Met Leu Asp Ile Ala Leu Asn Glu Ala Phe Asn Ile Leu Ser Asp Phe 
            340                 345                 350         


Asn His Thr Gly Gln Gly Ser Ile Cys Ser Gln Ala Ile Met Leu Ile 
        355                 360                 365             


Thr Asp Gly Ala Val Asp Thr Tyr Asp Thr Ile Phe Ala Lys Tyr Asn 
    370                 375                 380                 


Trp Pro Asp Arg Lys Val Arg Ile Phe Thr Tyr Leu Ile Gly Arg Glu 
385                 390                 395                 400 


Ala Ala Phe Ala Asp Asn Leu Lys Trp Met Ala Cys Ala Asn Lys Gly 
                405                 410                 415     


Phe Phe Thr Gln Ile Ser Thr Leu Ala Asp Val Gln Glu Asn Val Met 
            420                 425                 430         


Glu Tyr Leu His Val Leu Ser Arg Pro Lys Val Ile Asp Gln Glu His 
        435                 440                 445             


Asp Val Val Trp Thr Glu Ala Tyr Ile Asp Ser Thr Leu Pro Gln Ala 
    450                 455                 460                 


Gln Lys Leu Thr Asp Asp Gln Gly Pro Val Leu Met Thr Thr Val Ala 
465                 470                 475                 480 


Met Pro Val Phe Ser Lys Gln Asn Glu Thr Arg Ser Lys Gly Ile Leu 
                485                 490                 495     


Leu Gly Val Val Gly Thr Asp Val Pro Val Lys Glu Leu Leu Lys Thr 
            500                 505                 510         


Ile Pro Lys Tyr Lys Leu Gly Ile His Gly Tyr Ala Phe Ala Ile Thr 
        515                 520                 525             


Asn Asn Gly Tyr Ile Leu Thr His Pro Glu Leu Arg Leu Leu Tyr Glu 
    530                 535                 540                 


Glu Gly Lys Lys Arg Arg Lys Pro Asn Tyr Ser Ser Val Asp Leu Ser 
545                 550                 555                 560 


Glu Val Glu Trp Glu Asp Arg Asp Asp Val Leu Arg Asn Ala Met Val 
                565                 570                 575     


Asn Arg Lys Thr Gly Lys Phe Ser Met Glu Val Lys Lys Thr Val Asp 
            580                 585                 590         


Lys Gly Lys Arg Val Leu Val Met Thr Asn Asp Tyr Tyr Tyr Thr Asp 
        595                 600                 605             


Ile Lys Gly Thr Pro Phe Ser Leu Gly Val Ala Leu Ser Arg Gly His 
    610                 615                 620                 


Gly Lys Tyr Phe Phe Arg Gly Asn Val Thr Ile Glu Glu Gly Leu His 
625                 630                 635                 640 


Asp Leu Glu His Pro Asp Val Ser Leu Ala Asp Glu Trp Ser Tyr Cys 
                645                 650                 655     


Asn Thr Asp Leu His Pro Glu His Arg His Leu Ser Gln Leu Glu Ala 
            660                 665                 670         


Ile Lys Leu Tyr Leu Lys Gly Lys Glu Pro Leu Leu Gln Cys Asp Lys 
        675                 680                 685             


Glu Leu Ile Gln Glu Val Leu Phe Asp Ala Val Val Ser Ala Pro Ile 
    690                 695                 700                 


Glu Ala Tyr Trp Thr Ser Leu Ala Leu Asn Lys Ser Glu Asn Ser Asp 
705                 710                 715                 720 


Lys Gly Val Glu Val Ala Phe Leu Gly Thr Arg Thr Gly Leu Ser Arg 
                725                 730                 735     


Ile Asn Leu Phe Val Gly Ala Glu Gln Leu Thr Asn Gln Asp Phe Leu 
            740                 745                 750         


Lys Ala Gly Asp Lys Glu Asn Ile Phe Asn Ala Asp His Phe Pro Leu 
        755                 760                 765             


Trp Tyr Arg Arg Ala Ala Glu Gln Ile Pro Gly Ser Phe Val Tyr Ser 
    770                 775                 780                 


Ile Pro Phe Ser Thr Gly Pro Val Asn Lys Ser Asn Val Val Thr Ala 
785                 790                 795                 800 


Ser Thr Ser Ile Gln Leu Leu Asp Glu Arg Lys Ser Pro Val Val Ala 
                805                 810                 815     


Ala Val Gly Ile Gln Met Lys Leu Glu Phe Phe Gln Arg Lys Phe Trp 
            820                 825                 830         


Thr Ala Ser Arg Gln Cys Ala Ser Leu Asp Gly Lys Cys Ser Ile Ser 
        835                 840                 845             


Cys Asp Asp Glu Thr Val Asn Cys Tyr Leu Ile Asp Asn Asn Gly Phe 
    850                 855                 860                 


Ile Leu Val Ser Glu Asp Tyr Thr Gln Thr Gly Asp Phe Phe Gly Glu 
865                 870                 875                 880 


Ile Glu Gly Ala Val Met Asn Lys Leu Leu Thr Met Gly Ser Phe Lys 
                885                 890                 895     


Arg Ile Thr Leu Tyr Asp Tyr Gln Ala Met Cys Arg Ala Asn Lys Glu 
            900                 905                 910         


Ser Ser Asp Gly Ala His Gly Leu Leu Asp Pro Tyr Asn Ala Phe Leu 
        915                 920                 925             


Ser Ala Val Lys Trp Ile Met Thr Glu Leu Val Leu Phe Leu Val Glu 
    930                 935                 940                 


Phe Asn Leu Cys Ser Trp Trp His Ser Asp Met Thr Ala Lys Ala Gln 
945                 950                 955                 960 


Lys Leu Lys Gln Thr Leu Glu Pro Cys Asp Thr Glu Tyr Pro Ala Phe 
                965                 970                 975     


Val Ser Glu Arg Thr Ile Lys Glu Thr Thr Gly Asn Ile Ala Cys Glu 
            980                 985                 990         


Asp Cys Ser Lys Ser Phe Val Ile  Gln Gln Ile Pro Ser  Ser Asn Leu 
        995                 1000                 1005             


Phe Met  Val Val Val Asp Ser  Ser Cys Leu Cys Glu  Ser Val Ala 
    1010                 1015                 1020             


Pro Ile  Thr Met Ala Pro Ile  Glu Ile Arg Tyr Asn  Glu Ser Leu 
    1025                 1030                 1035             


Lys Cys  Glu Arg Leu Lys Ala  Gln Lys Ile Arg Arg  Arg Pro Glu 
    1040                 1045                 1050             


Ser Cys  His Gly Phe His Pro  Glu Glu Asn Ala Arg  Glu Cys Gly 
    1055                 1060                 1065             


Gly Ala  Pro Ser Leu Gln Ala  Gln Thr Val Leu Leu  Leu Leu Pro 
    1070                 1075                 1080             


Leu Leu  Leu Met Leu Phe Ser  Arg 
    1085                 1090     


<210>  1505
<211>  1137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNA2D4__Homo_sapiens__NP_758952

<400>  1505

Met Val Cys Gly Cys Ser Ala Leu Leu Pro Leu Pro Asn Pro Arg Pro 
1               5                   10                  15      


Thr Met Pro Ala Thr Pro Asn Phe Leu Ala Asn Pro Ser Ser Ser Ser 
            20                  25                  30          


Arg Trp Ile Pro Leu Gln Pro Met Pro Val Ala Trp Ala Phe Val Gln 
        35                  40                  45              


Lys Thr Ser Ala Leu Leu Trp Leu Leu Leu Leu Gly Thr Ser Leu Ser 
    50                  55                  60                  


Pro Ala Trp Gly Gln Ala Lys Ile Pro Leu Glu Thr Val Lys Leu Trp 
65                  70                  75                  80  


Ala Asp Thr Phe Gly Gly Asp Leu Tyr Asn Thr Val Thr Lys Tyr Ser 
                85                  90                  95      


Gly Ser Leu Leu Leu Gln Lys Lys Tyr Lys Asp Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Ile Glu Glu Val Asp Gly Leu Glu Leu Val Arg Lys Phe Ser Glu 
        115                 120                 125             


Asp Met Glu Asn Met Leu Arg Arg Lys Val Glu Ala Val Gln Asn Leu 
    130                 135                 140                 


Val Glu Ala Ala Glu Glu Ala Asp Leu Asn His Glu Phe Asn Glu Ser 
145                 150                 155                 160 


Leu Val Phe Asp Tyr Tyr Asn Ser Val Leu Ile Asn Glu Arg Asp Glu 
                165                 170                 175     


Lys Gly Asn Phe Val Glu Leu Gly Ala Glu Phe Leu Leu Glu Ser Asn 
            180                 185                 190         


Ala His Phe Ser Asn Leu Pro Val Asn Thr Ser Ile Ser Ser Val Gln 
        195                 200                 205             


Leu Pro Thr Asn Val Tyr Asn Lys Asp Pro Asp Ile Leu Asn Gly Val 
    210                 215                 220                 


Tyr Met Ser Glu Ala Leu Asn Ala Val Phe Val Glu Asn Phe Gln Arg 
225                 230                 235                 240 


Asp Pro Thr Leu Thr Trp Gln Tyr Phe Gly Ser Ala Thr Gly Phe Phe 
                245                 250                 255     


Arg Ile Tyr Pro Gly Ile Lys Trp Thr Pro Asp Glu Asn Gly Val Ile 
            260                 265                 270         


Thr Phe Asp Cys Arg Asn Arg Gly Trp Tyr Ile Gln Ala Ala Thr Ser 
        275                 280                 285             


Pro Lys Asp Ile Val Ile Leu Val Asp Val Ser Gly Ser Met Lys Gly 
    290                 295                 300                 


Leu Arg Met Thr Ile Ala Lys His Thr Ile Thr Thr Ile Leu Asp Thr 
305                 310                 315                 320 


Leu Gly Glu Asn Asp Phe Ile Asn Ile Ile Ala Tyr Asn Asp Tyr Val 
                325                 330                 335     


His Tyr Ile Glu Pro Cys Phe Lys Gly Ile Leu Val Gln Ala Asp Arg 
            340                 345                 350         


Asp Asn Arg Glu His Phe Lys Leu Leu Val Glu Glu Leu Met Val Lys 
        355                 360                 365             


Gly Val Gly Val Val Asp Gln Ala Leu Arg Glu Ala Phe Gln Ile Leu 
    370                 375                 380                 


Lys Gln Phe Gln Glu Ala Lys Gln Gly Ser Leu Cys Asn Gln Ala Ile 
385                 390                 395                 400 


Met Leu Ile Ser Asp Gly Ala Val Glu Asp Tyr Glu Pro Val Phe Glu 
                405                 410                 415     


Lys Tyr Asn Trp Pro Asp Cys Lys Val Arg Val Phe Thr Tyr Leu Ile 
            420                 425                 430         


Gly Arg Glu Val Ser Phe Ala Asp Arg Met Lys Trp Ile Ala Cys Asn 
        435                 440                 445             


Asn Lys Gly Tyr Tyr Thr Gln Ile Ser Thr Leu Ala Asp Thr Gln Glu 
    450                 455                 460                 


Asn Val Met Glu Tyr Leu His Val Leu Ser Arg Pro Met Val Ile Asn 
465                 470                 475                 480 


His Asp His Asp Ile Ile Trp Thr Glu Ala Tyr Met Asp Ser Lys Leu 
                485                 490                 495     


Leu Ser Ser Gln Ala Gln Ser Leu Thr Leu Leu Thr Thr Val Ala Met 
            500                 505                 510         


Pro Val Phe Ser Lys Lys Asn Glu Thr Arg Ser His Gly Ile Leu Leu 
        515                 520                 525             


Gly Val Val Gly Ser Asp Val Ala Leu Arg Glu Leu Met Lys Leu Ala 
    530                 535                 540                 


Pro Arg Tyr Lys Leu Gly Val His Gly Tyr Ala Phe Leu Asn Thr Asn 
545                 550                 555                 560 


Asn Gly Tyr Ile Leu Ser His Pro Asp Leu Arg Pro Leu Tyr Arg Glu 
                565                 570                 575     


Gly Lys Lys Leu Lys Pro Lys Pro Asn Tyr Asn Ser Val Asp Leu Ser 
            580                 585                 590         


Glu Val Glu Trp Glu Asp Gln Ala Glu Ser Leu Arg Thr Ala Met Ile 
        595                 600                 605             


Asn Arg Glu Thr Gly Thr Leu Ser Met Asp Val Lys Val Pro Met Asp 
    610                 615                 620                 


Lys Gly Lys Arg Val Leu Phe Leu Thr Asn Asp Tyr Phe Phe Thr Asp 
625                 630                 635                 640 


Ile Ser Asp Thr Pro Phe Ser Leu Gly Val Val Leu Ser Arg Gly His 
                645                 650                 655     


Gly Glu Tyr Ile Leu Leu Gly Asn Thr Ser Val Glu Glu Gly Leu His 
            660                 665                 670         


Asp Leu Leu His Pro Asp Leu Ala Leu Ala Gly Asp Trp Ile Tyr Cys 
        675                 680                 685             


Ile Thr Asp Ile Asp Pro Asp His Arg Lys Leu Ser Gln Leu Glu Ala 
    690                 695                 700                 


Met Ile Arg Phe Leu Thr Arg Lys Asp Pro Asp Leu Glu Cys Asp Glu 
705                 710                 715                 720 


Glu Leu Val Arg Glu Val Leu Phe Asp Ala Val Val Thr Ala Pro Met 
                725                 730                 735     


Glu Ala Tyr Trp Thr Ala Leu Ala Leu Asn Met Ser Glu Glu Ser Glu 
            740                 745                 750         


His Val Val Asp Met Ala Phe Leu Gly Thr Arg Ala Gly Leu Leu Arg 
        755                 760                 765             


Ser Ser Leu Phe Val Gly Ser Glu Lys Val Ser Asp Arg Lys Phe Leu 
    770                 775                 780                 


Thr Pro Glu Asp Glu Ala Ser Val Phe Thr Leu Asp Arg Phe Pro Leu 
785                 790                 795                 800 


Trp Tyr Arg Gln Ala Ser Glu His Pro Ala Gly Ser Phe Val Phe Asn 
                805                 810                 815     


Leu Arg Trp Ala Glu Gly Pro Glu Ser Ala Gly Glu Pro Met Val Val 
            820                 825                 830         


Thr Ala Ser Thr Ala Val Ala Val Thr Val Asp Lys Arg Thr Ala Ile 
        835                 840                 845             


Ala Ala Ala Ala Gly Val Gln Met Lys Leu Glu Phe Leu Gln Arg Lys 
    850                 855                 860                 


Phe Trp Ala Ala Thr Arg Gln Cys Ser Thr Val Asp Gly Pro Cys Thr 
865                 870                 875                 880 


Gln Ser Cys Glu Asp Ser Asp Leu Asp Cys Phe Val Ile Asp Asn Asn 
                885                 890                 895     


Gly Phe Ile Leu Ile Ser Lys Arg Ser Arg Glu Thr Gly Arg Phe Leu 
            900                 905                 910         


Gly Glu Val Asp Gly Ala Val Leu Thr Gln Leu Leu Ser Met Gly Val 
        915                 920                 925             


Phe Ser Gln Val Thr Met Tyr Asp Tyr Gln Ala Met Cys Lys Pro Ser 
    930                 935                 940                 


Ser His His His Ser Ala Ala Gln Pro Leu Val Ser Pro Ile Ser Ala 
945                 950                 955                 960 


Phe Leu Thr Ala Thr Arg Trp Leu Leu Gln Glu Leu Val Leu Phe Leu 
                965                 970                 975     


Leu Glu Trp Ser Val Trp Gly Ser Trp Tyr Asp Arg Gly Ala Glu Ala 
            980                 985                 990         


Lys Ser Val Phe His His Ser His  Lys His Lys Lys Gln  Asp Pro Leu 
        995                 1000                 1005             


Gln Pro  Cys Asp Thr Glu Tyr  Pro Val Phe Val Tyr  Gln Pro Ala 
    1010                 1015                 1020             


Ile Arg  Glu Ala Asn Gly Ile  Val Glu Cys Gly Pro  Cys Gln Lys 
    1025                 1030                 1035             


Val Phe  Val Val Gln Gln Ile  Pro Asn Ser Asn Leu  Leu Leu Leu 
    1040                 1045                 1050             


Val Thr  Asp Pro Thr Cys Asp  Cys Ser Ile Phe Pro  Pro Val Leu 
    1055                 1060                 1065             


Gln Glu  Ala Thr Glu Val Lys  Tyr Asn Ala Ser Val  Lys Cys Asp 
    1070                 1075                 1080             


Arg Met  Arg Ser Gln Lys Leu  Arg Arg Arg Pro Asp  Ser Cys His 
    1085                 1090                 1095             


Ala Phe  His Pro Glu Glu Asn  Ala Gln Asp Cys Gly  Gly Ala Ser 
    1100                 1105                 1110             


Asp Thr  Ser Ala Ser Pro Pro  Leu Leu Leu Leu Pro  Val Cys Ala 
    1115                 1120                 1125             


Trp Gly  Leu Leu Pro Gln Leu  Leu Arg 
    1130                 1135         


<210>  1506
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNB1__Homo_sapiens__NP_000714

<400>  1506

Met Val Gln Lys Thr Ser Met Ser Arg Gly Pro Tyr Pro Pro Ser Gln 
1               5                   10                  15      


Glu Ile Pro Met Glu Val Phe Asp Pro Ser Pro Gln Gly Lys Tyr Ser 
            20                  25                  30          


Lys Arg Lys Gly Arg Phe Lys Arg Ser Asp Gly Ser Thr Ser Ser Asp 
        35                  40                  45              


Thr Thr Ser Asn Ser Phe Val Arg Gln Gly Ser Ala Glu Ser Tyr Thr 
    50                  55                  60                  


Ser Arg Pro Ser Asp Ser Asp Val Ser Leu Glu Glu Asp Arg Glu Ala 
65                  70                  75                  80  


Leu Arg Lys Glu Ala Glu Arg Gln Ala Leu Ala Gln Leu Glu Lys Ala 
                85                  90                  95      


Lys Thr Lys Pro Val Ala Phe Ala Val Arg Thr Asn Val Gly Tyr Asn 
            100                 105                 110         


Pro Ser Pro Gly Asp Glu Val Pro Val Gln Gly Val Ala Ile Thr Phe 
        115                 120                 125             


Glu Pro Lys Asp Phe Leu His Ile Lys Glu Lys Tyr Asn Asn Asp Trp 
    130                 135                 140                 


Trp Ile Gly Arg Leu Val Lys Glu Gly Cys Glu Val Gly Phe Ile Pro 
145                 150                 155                 160 


Ser Pro Val Lys Leu Asp Ser Leu Arg Leu Leu Gln Glu Gln Lys Leu 
                165                 170                 175     


Arg Gln Asn Arg Leu Gly Ser Ser Lys Ser Gly Asp Asn Ser Ser Ser 
            180                 185                 190         


Ser Leu Gly Asp Val Val Thr Gly Thr Arg Arg Pro Thr Pro Pro Ala 
        195                 200                 205             


Ser Ala Lys Gln Lys Gln Lys Ser Thr Glu His Val Pro Pro Tyr Asp 
    210                 215                 220                 


Val Val Pro Ser Met Arg Pro Ile Ile Leu Val Gly Pro Ser Leu Lys 
225                 230                 235                 240 


Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu 
                245                 250                 255     


Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp 
            260                 265                 270         


Ile Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ile 
        275                 280                 285             


Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser 
    290                 295                 300                 


Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Ala 
305                 310                 315                 320 


Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser 
                325                 330                 335     


Leu Ala Pro Ile Ile Val Tyr Ile Lys Ile Thr Ser Pro Lys Val Leu 
            340                 345                 350         


Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser Gln Ser Lys His Leu Asn 
        355                 360                 365             


Val Gln Ile Ala Ala Ser Glu Lys Leu Ala Gln Cys Pro Pro Glu Met 
    370                 375                 380                 


Phe Asp Ile Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His 
385                 390                 395                 400 


Leu Ala Glu Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser 
                405                 410                 415     


Ser Thr Pro Pro Asn Pro Leu Leu Asn Arg Thr Met Ala Thr Ala Ala 
            420                 425                 430         


Leu Ala Ala Ser Pro Ala Pro Val Ser Asn Leu Gln Gly Pro Tyr Leu 
        435                 440                 445             


Ala Ser Gly Asp Gln Pro Leu Glu Arg Ala Thr Gly Glu His Ala Ser 
    450                 455                 460                 


Met His Glu Tyr Pro Gly Glu Leu Gly Gln Pro Pro Gly Leu Tyr Pro 
465                 470                 475                 480 


Ser Ser His Pro Pro Gly Arg Ala Gly Thr Leu Arg Ala Leu Ser Arg 
                485                 490                 495     


Gln Asp Thr Phe Asp Ala Asp Thr Pro Gly Ser Arg Asn Ser Ala Tyr 
            500                 505                 510         


Thr Glu Leu Gly Asp Ser Cys Val Asp Met Glu Thr Asp Pro Ser Glu 
        515                 520                 525             


Gly Pro Gly Leu Gly Asp Pro Ala Gly Gly Gly Thr Pro Pro Ala Arg 
    530                 535                 540                 


Gln Gly Ser Trp Glu Asp Glu Glu Glu Asp Tyr Glu Glu Glu Leu Thr 
545                 550                 555                 560 


Asp Asn Arg Asn Arg Gly Arg Asn Lys Ala Arg Tyr Cys Ala Glu Gly 
                565                 570                 575     


Gly Gly Pro Val Leu Gly Arg Asn Lys Asn Glu Leu Glu Gly Trp Gly 
            580                 585                 590         


Arg Gly Val Tyr Ile Arg 
        595             


<210>  1507
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNB2__Homo_sapiens__NP_000715

<400>  1507

Met Gln Cys Cys Gly Leu Val His Arg Arg Arg Val Arg Val Ser Tyr 
1               5                   10                  15      


Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ala Val Arg Arg Glu Ala Glu Arg Gln Ala 
        35                  40                  45              


Gln Ala Gln Leu Glu Lys Ala Lys Thr Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Thr Asn Val Ser Tyr Ser Ala Ala His Glu Asp Asp Val Pro Val 
65                  70                  75                  80  


Pro Gly Met Ala Ile Ser Phe Glu Ala Lys Asp Phe Leu His Val Lys 
                85                  90                  95      


Glu Lys Phe Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
            100                 105                 110         


Cys Glu Ile Gly Phe Ile Pro Ser Pro Val Lys Leu Glu Asn Met Arg 
        115                 120                 125             


Leu Gln His Glu Gln Arg Ala Lys Gln Gly Lys Phe Tyr Ser Ser Lys 
    130                 135                 140                 


Ser Gly Gly Asn Ser Ser Ser Ser Leu Gly Asp Ile Val Pro Ser Ser 
145                 150                 155                 160 


Arg Lys Ser Thr Pro Pro Ser Ser Ala Ile Asp Ile Asp Ala Thr Gly 
                165                 170                 175     


Leu Asp Ala Glu Glu Asn Asp Ile Pro Ala Asn His Arg Ser Pro Lys 
            180                 185                 190         


Pro Ser Ala Asn Ser Val Thr Ser Pro His Ser Lys Glu Lys Arg Met 
        195                 200                 205             


Pro Phe Phe Lys Lys Thr Glu His Thr Pro Pro Tyr Asp Val Val Pro 
    210                 215                 220                 


Ser Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu 
225                 230                 235                 240 


Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg 
                245                 250                 255     


Phe Glu Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu 
            260                 265                 270         


Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ala Ile Ile Glu 
        275                 280                 285             


Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu 
    290                 295                 300                 


Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Val Leu Asp Ala 
305                 310                 315                 320 


Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro 
                325                 330                 335     


Ile Ile Val Tyr Val Lys Ile Ser Ser Pro Lys Val Leu Gln Arg Leu 
            340                 345                 350         


Ile Lys Ser Arg Gly Lys Ser Gln Ala Lys His Leu Asn Val Gln Met 
        355                 360                 365             


Val Ala Ala Asp Lys Leu Ala Gln Cys Pro Pro Glu Leu Phe Asp Val 
    370                 375                 380                 


Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Asp 
385                 390                 395                 400 


Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Ser Leu 
                405                 410                 415     


Pro Asn Pro Leu Leu Ser Arg Thr Leu Ala Thr Ser Ser Leu Pro Leu 
            420                 425                 430         


Ser Pro Thr Leu Ala Ser Asn Ser Gln Gly Ser Gln Gly Asp Gln Arg 
        435                 440                 445             


Thr Asp Arg Ser Ala Pro Ile Arg Ser Ala Ser Gln Ala Glu Glu Glu 
    450                 455                 460                 


Pro Ser Val Glu Pro Val Lys Lys Ser Gln His Arg Ser Ser Ser Ser 
465                 470                 475                 480 


Ala Pro His His Asn His Arg Ser Gly Thr Ser Arg Gly Leu Ser Arg 
                485                 490                 495     


Gln Glu Thr Phe Asp Ser Glu Thr Gln Glu Ser Arg Asp Ser Ala Tyr 
            500                 505                 510         


Val Glu Pro Lys Glu Asp Tyr Ser His Asp His Val Asp His Tyr Ala 
        515                 520                 525             


Ser His Arg Asp His Asn His Arg Asp Glu Thr His Gly Ser Ser Asp 
    530                 535                 540                 


His Arg His Arg Glu Ser Arg His Arg Ser Arg Asp Val Asp Arg Glu 
545                 550                 555                 560 


Gln Asp His Asn Glu Cys Asn Lys Gln Arg Ser Arg His Lys Ser Lys 
                565                 570                 575     


Asp Arg Tyr Cys Glu Lys Asp Gly Glu Val Ile Ser Lys Lys Arg Asn 
            580                 585                 590         


Glu Ala Gly Glu Trp Asn Arg Asp Val Tyr Ile Arg Gln 
        595                 600                 605 


<210>  1508
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNB3__Homo_sapiens__NP_000716

<400>  1508

Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Thr Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
65                  70                  75                  80  


Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                85                  90                  95      


Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
            100                 105                 110         


Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg 
        115                 120                 125             


Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu 
    130                 135                 140                 


Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln 
145                 150                 155                 160 


Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser 
                165                 170                 175     


Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
            180                 185                 190         


Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
        195                 200                 205             


Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu Ser Leu Ala 
    210                 215                 220                 


Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile Ile Glu Arg 
225                 230                 235                 240 


Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg 
                245                 250                 255     


Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp 
            260                 265                 270         


Thr Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu Ala Pro Ile 
        275                 280                 285             


Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile 
    290                 295                 300                 


Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val Gln Met Met 
305                 310                 315                 320 


Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile 
                325                 330                 335     


Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr 
            340                 345                 350         


Leu Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro Gly Pro Gly 
        355                 360                 365             


Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu 
    370                 375                 380                 


Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu 
385                 390                 395                 400 


Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Thr Gly 
                405                 410                 415     


Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala 
            420                 425                 430         


Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Thr Ser Gly Leu Pro 
        435                 440                 445             


Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser 
    450                 455                 460                 


Glu His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro 
465                 470                 475                 480 


Lys Asp Ser Tyr 
                


<210>  1509
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNB4__Homo_sapiens__NP_000717

<400>  1509

Met Ser Ser Ser Ser Tyr Ala Lys Asn Gly Thr Ala Asp Gly Pro His 
1               5                   10                  15      


Ser Pro Thr Ser Gln Val Ala Arg Gly Thr Thr Thr Arg Arg Ser Arg 
            20                  25                  30          


Leu Lys Arg Ser Asp Gly Ser Thr Thr Ser Thr Ser Phe Ile Leu Arg 
        35                  40                  45              


Gln Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val 
    50                  55                  60                  


Ser Leu Glu Glu Asp Arg Glu Ala Ile Arg Gln Glu Arg Glu Gln Gln 
65                  70                  75                  80  


Ala Ala Ile Gln Leu Glu Arg Ala Lys Ser Lys Pro Val Ala Phe Ala 
                85                  90                  95      


Val Lys Thr Asn Val Ser Tyr Cys Gly Ala Leu Asp Glu Asp Val Pro 
            100                 105                 110         


Val Pro Ser Thr Ala Ile Ser Phe Asp Ala Lys Asp Phe Leu His Ile 
        115                 120                 125             


Lys Glu Lys Tyr Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu 
    130                 135                 140                 


Gly Cys Glu Ile Gly Phe Ile Pro Ser Pro Leu Arg Leu Glu Asn Ile 
145                 150                 155                 160 


Arg Ile Gln Gln Glu Gln Lys Arg Gly Arg Phe His Gly Gly Lys Ser 
                165                 170                 175     


Ser Gly Asn Ser Ser Ser Ser Leu Gly Glu Met Val Ser Gly Thr Phe 
            180                 185                 190         


Arg Ala Thr Pro Thr Ser Thr Ala Lys Gln Lys Gln Lys Val Thr Glu 
        195                 200                 205             


His Ile Pro Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu 
    210                 215                 220                 


Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys 
225                 230                 235                 240 


Ala Leu Phe Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile 
                245                 250                 255     


Thr Arg Val Thr Ala Asp Ile Ser Leu Ala Lys Arg Ser Val Leu Asn 
            260                 265                 270         


Asn Pro Ser Lys Arg Ala Ile Ile Glu Arg Ser Asn Thr Arg Ser Ser 
        275                 280                 285             


Leu Ala Glu Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Arg 
    290                 295                 300                 


Ser Leu Gln Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala 
305                 310                 315                 320 


Gln Leu Ile Lys Thr Ser Leu Ala Pro Ile Ile Val His Val Lys Val 
                325                 330                 335     


Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Lys Ser Arg Gly Lys Ser 
            340                 345                 350         


Gln Ser Lys His Leu Asn Val Gln Leu Val Ala Ala Asp Lys Leu Ala 
        355                 360                 365             


Gln Cys Pro Pro Glu Met Phe Asp Val Ile Leu Asp Glu Asn Gln Leu 
    370                 375                 380                 


Glu Asp Ala Cys Glu His Leu Gly Glu Tyr Leu Glu Ala Tyr Trp Arg 
385                 390                 395                 400 


Ala Thr His Thr Thr Ser Ser Thr Pro Met Thr Pro Leu Leu Gly Arg 
                405                 410                 415     


Asn Leu Gly Ser Thr Ala Leu Ser Pro Tyr Pro Thr Ala Ile Ser Gly 
            420                 425                 430         


Leu Gln Ser Gln Arg Met Arg His Ser Asn His Ser Thr Glu Asn Ser 
        435                 440                 445             


Pro Ile Glu Arg Arg Ser Leu Met Thr Ser Asp Glu Asn Tyr His Asn 
    450                 455                 460                 


Glu Arg Ala Arg Lys Ser Arg Asn Arg Leu Ser Ser Ser Ser Gln His 
465                 470                 475                 480 


Ser Arg Asp His Tyr Pro Leu Val Glu Glu Asp Tyr Pro Asp Ser Tyr 
                485                 490                 495     


Gln Asp Thr Tyr Lys Pro His Arg Asn Arg Gly Ser Pro Gly Gly Tyr 
            500                 505                 510         


Ser His Asp Ser Arg His Arg Leu 
        515                 520 


<210>  1510
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNG2__Homo_sapiens__NP_006069

<400>  1510

Met Gly Leu Phe Asp Arg Gly Val Gln Met Leu Leu Thr Thr Val Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Thr Ile Ala Val Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Arg Gly Val Cys Lys Thr Lys Ser Val Ser Glu Asn 
        35                  40                  45              


Glu Thr Ser Lys Lys Asn Glu Glu Val Met Thr His Ser Gly Leu Trp 
    50                  55                  60                  


Arg Thr Cys Cys Leu Glu Gly Asn Phe Lys Gly Leu Cys Lys Gln Ile 
65                  70                  75                  80  


Asp His Phe Pro Glu Asp Ala Asp Tyr Glu Ala Asp Thr Ala Glu Tyr 
                85                  90                  95      


Phe Leu Arg Ala Val Arg Ala Ser Ser Ile Phe Pro Ile Leu Ser Val 
            100                 105                 110         


Ile Leu Leu Phe Met Gly Gly Leu Cys Ile Ala Ala Ser Glu Phe Tyr 
        115                 120                 125             


Lys Thr Arg His Asn Ile Ile Leu Ser Ala Gly Ile Phe Phe Val Ser 
    130                 135                 140                 


Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile Ser Ala Asn 
145                 150                 155                 160 


Ala Gly Asp Pro Ser Lys Ser Asp Ser Lys Lys Asn Ser Tyr Ser Tyr 
                165                 170                 175     


Gly Trp Ser Phe Tyr Phe Gly Ala Leu Ser Phe Ile Ile Ala Glu Met 
            180                 185                 190         


Val Gly Val Leu Ala Val His Met Phe Ile Asp Arg His Lys Gln Leu 
        195                 200                 205             


Arg Ala Thr Ala Arg Ala Thr Asp Tyr Leu Gln Ala Ser Ala Ile Thr 
    210                 215                 220                 


Arg Ile Pro Ser Tyr Arg Tyr Arg Tyr Gln Arg Arg Ser Arg Ser Ser 
225                 230                 235                 240 


Ser Arg Ser Thr Glu Pro Ser His Ser Arg Asp Ala Ser Pro Val Gly 
                245                 250                 255     


Ile Lys Gly Phe Asn Thr Leu Pro Ser Thr Glu Ile Ser Met Tyr Thr 
            260                 265                 270         


Leu Ser Arg Asp Pro Leu Lys Ala Ala Thr Thr Pro Thr Ala Thr Tyr 
        275                 280                 285             


Asn Ser Asp Arg Asp Asn Ser Phe Leu Gln Val His Asn Cys Ile Gln 
    290                 295                 300                 


Lys Glu Asn Lys Asp Ser Leu His Ser Asn Thr Ala Asn Arg Arg Thr 
305                 310                 315                 320 


Thr Pro Val 
            


<210>  1511
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNG3__Homo_sapiens__NP_006530

<400>  1511

Met Arg Met Cys Asp Arg Gly Ile Gln Met Leu Ile Thr Thr Val Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Thr Ile Ala Val Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Arg Gly Val Cys Arg Thr Lys Ser Thr Ser Asp Asn 
        35                  40                  45              


Glu Thr Ser Arg Lys Asn Glu Glu Val Met Thr His Ser Gly Leu Trp 
    50                  55                  60                  


Arg Thr Cys Cys Leu Glu Gly Ala Phe Arg Gly Val Cys Lys Lys Ile 
65                  70                  75                  80  


Asp His Phe Pro Glu Asp Ala Asp Tyr Glu Gln Asp Thr Ala Glu Tyr 
                85                  90                  95      


Leu Leu Arg Ala Val Arg Ala Ser Ser Val Phe Pro Ile Leu Ser Val 
            100                 105                 110         


Thr Leu Leu Phe Phe Gly Gly Leu Cys Val Ala Ala Ser Glu Phe His 
        115                 120                 125             


Arg Ser Arg His Asn Val Ile Leu Ser Ala Gly Ile Phe Phe Val Ser 
    130                 135                 140                 


Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile Ser Ala Asn 
145                 150                 155                 160 


Ala Gly Asp Pro Gly Gln Arg Asp Ser Lys Lys Ser Tyr Ser Tyr Gly 
                165                 170                 175     


Trp Ser Phe Tyr Phe Gly Ala Phe Ser Phe Ile Ile Ala Glu Ile Val 
            180                 185                 190         


Gly Val Val Ala Val His Ile Tyr Ile Glu Lys His Gln Gln Leu Arg 
        195                 200                 205             


Ala Lys Ser His Ser Glu Phe Leu Lys Lys Ser Thr Phe Ala Arg Leu 
    210                 215                 220                 


Pro Pro Tyr Arg Tyr Arg Phe Arg Arg Arg Ser Ser Ser Arg Ser Thr 
225                 230                 235                 240 


Glu Pro Arg Ser Arg Asp Leu Ser Pro Ile Ser Lys Gly Phe His Thr 
                245                 250                 255     


Ile Pro Ser Thr Asp Ile Ser Met Phe Thr Leu Ser Arg Asp Pro Ser 
            260                 265                 270         


Lys Ile Thr Met Gly Thr Leu Leu Asn Ser Asp Arg Asp His Ala Phe 
        275                 280                 285             


Leu Gln Phe His Asn Ser Thr Pro Lys Glu Phe Lys Glu Ser Leu His 
    290                 295                 300                 


Asn Asn Pro Ala Asn Arg Arg Thr Thr Pro Val 
305                 310                 315 


<210>  1512
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNG4__Homo_sapiens__NP_055220

<400>  1512

Met Val Arg Cys Asp Arg Gly Leu Gln Met Leu Leu Thr Thr Ala Gly 
1               5                   10                  15      


Ala Phe Ala Ala Phe Ser Leu Met Ala Ile Ala Ile Gly Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Ser Ser Ala His Ile Cys Asn Gly Thr Asn Leu Thr Met 
        35                  40                  45              


Asp Asp Gly Pro Pro Pro Arg Arg Ala Arg Gly Asp Leu Thr His Ser 
    50                  55                  60                  


Gly Leu Trp Arg Val Cys Cys Ile Glu Gly Ile Tyr Lys Gly His Cys 
65                  70                  75                  80  


Phe Arg Ile Asn His Phe Pro Glu Asp Asn Asp Tyr Asp His Asp Ser 
                85                  90                  95      


Ser Glu Tyr Leu Leu Arg Ile Val Arg Ala Ser Ser Val Phe Pro Ile 
            100                 105                 110         


Leu Ser Thr Ile Leu Leu Leu Leu Gly Gly Leu Cys Ile Gly Ala Gly 
        115                 120                 125             


Arg Ile Tyr Ser Arg Lys Asn Asn Ile Val Leu Ser Ala Gly Ile Leu 
    130                 135                 140                 


Phe Val Ala Ala Gly Leu Ser Asn Ile Ile Gly Ile Ile Val Tyr Ile 
145                 150                 155                 160 


Ser Ser Asn Thr Gly Asp Pro Ser Asp Lys Arg Asp Glu Asp Lys Lys 
                165                 170                 175     


Asn His Tyr Asn Tyr Gly Trp Ser Phe Tyr Phe Gly Ala Leu Ser Phe 
            180                 185                 190         


Ile Val Ala Glu Thr Val Gly Val Leu Ala Val Asn Ile Tyr Ile Glu 
        195                 200                 205             


Lys Asn Lys Glu Leu Arg Phe Lys Thr Lys Arg Glu Phe Leu Lys Ala 
    210                 215                 220                 


Ser Ser Ser Ser Pro Tyr Ala Arg Met Pro Ser Tyr Arg Tyr Arg Arg 
225                 230                 235                 240 


Arg Arg Ser Arg Ser Ser Ser Arg Ser Thr Glu Ala Ser Pro Ser Arg 
                245                 250                 255     


Asp Val Ser Pro Met Gly Leu Lys Ile Thr Gly Ala Ile Pro Met Gly 
            260                 265                 270         


Glu Leu Ser Met Tyr Thr Leu Ser Arg Glu Pro Leu Lys Val Thr Thr 
        275                 280                 285             


Ala Ala Ser Tyr Ser Pro Asp Gln Glu Ala Ser Phe Leu Gln Val His 
    290                 295                 300                 


Asp Phe Phe Gln Gln Asp Leu Lys Glu Gly Phe His Val Ser Met Leu 
305                 310                 315                 320 


Asn Arg Arg Thr Thr Pro Val 
                325         


<210>  1513
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNG5__Homo_sapiens__XP_011522915

<400>  1513

Met Ser Ala Cys Gly Arg Lys Ala Leu Thr Leu Leu Ser Ser Val Phe 
1               5                   10                  15      


Ala Val Cys Gly Leu Gly Leu Leu Gly Ile Ala Val Ser Thr Asp Tyr 
            20                  25                  30          


Trp Leu Tyr Leu Glu Glu Gly Val Ile Val Pro Gln Asn Gln Ser Thr 
        35                  40                  45              


Glu Ile Lys Met Ser Leu His Ser Gly Leu Trp Arg Val Cys Phe Leu 
    50                  55                  60                  


Ala Gly Glu Glu Arg Gly Arg Cys Phe Thr Ile Glu Tyr Val Met Pro 
65                  70                  75                  80  


Met Asn Thr Gln Leu Thr Ser Glu Ser Thr Val Asn Val Leu Lys Met 
                85                  90                  95      


Ile Arg Ser Ala Thr Pro Phe Pro Leu Val Ser Leu Phe Phe Met Phe 
            100                 105                 110         


Ile Gly Phe Ile Leu Asn Asn Ile Gly His Ile Arg Pro His Arg Thr 
        115                 120                 125             


Ile Leu Ala Phe Val Ser Gly Ile Phe Phe Ile Leu Ser Gly Leu Ser 
    130                 135                 140                 


Leu Val Val Gly Leu Val Leu Tyr Ile Ser Ser Ile Asn Asp Glu Met 
145                 150                 155                 160 


Leu Asn Arg Thr Lys Asp Ala Glu Thr Tyr Phe Asn Tyr Lys Tyr Gly 
                165                 170                 175     


Trp Ser Phe Ala Phe Ala Ala Ile Ser Phe Leu Leu Thr Glu Ser Ala 
            180                 185                 190         


Gly Val Met Ser Val Tyr Leu Phe Met Lys Arg Tyr Thr Ala Glu Asp 
        195                 200                 205             


Met Tyr Arg Pro His Pro Gly Phe Tyr Arg Pro Arg Leu Ser Asn Cys 
    210                 215                 220                 


Ser Asp Tyr Ser Gly Gln Phe Leu His Pro Asp Ala Trp Val Arg Gly 
225                 230                 235                 240 


Arg Ser Pro Ser Asp Ile Ser Ser Glu Ala Ser Leu Gln Met Asn Ser 
                245                 250                 255     


Asn Tyr Pro Ala Leu Leu Lys Cys Pro Asp Tyr Asp Gln Met Ser Ser 
            260                 265                 270         


Ser Pro Cys 
        275 


<210>  1514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACNG6__Homo_sapiens__NP_114103

<400>  1514

Met Met Trp Ser Asn Phe Phe Leu Gln Glu Glu Asn Arg Arg Arg Gly 
1               5                   10                  15      


Ala Ala Gly Arg Arg Arg Ala His Gly Gln Gly Arg Ser Gly Leu Thr 
            20                  25                  30          


Pro Glu Arg Glu Gly Lys Val Lys Leu Ala Leu Leu Leu Ala Ala Val 
        35                  40                  45              


Gly Ala Thr Leu Ala Val Leu Ser Val Gly Thr Glu Phe Trp Val Glu 
    50                  55                  60                  


Leu Asn Thr Tyr Lys Ala Asn Gly Ser Ala Val Cys Glu Ala Ala His 
65                  70                  75                  80  


Leu Gly Leu Trp Lys Ala Cys Thr Lys Arg Leu Trp Gln Ala Asp Val 
                85                  90                  95      


Pro Val Asp Arg Asp Thr Cys Gly Pro Ala Glu Leu Pro Gly Gly Leu 
            100                 105                 110         


Leu Leu Leu Val Ser Leu Glu Val Phe Arg His Ser Val Arg Ala Leu 
        115                 120                 125             


Leu Gln Arg Val Ser Pro Glu Pro Pro Pro Ala Pro Arg Leu Thr Tyr 
    130                 135                 140                 


Glu Tyr Ser Trp Ser Leu Gly Cys Gly Val Gly Ala Gly Leu Ile Leu 
145                 150                 155                 160 


Leu Leu Gly Ala Gly Cys Phe Leu Leu Leu Thr Leu Pro Ser Trp Pro 
                165                 170                 175     


Trp Gly Ser Leu Cys Pro Lys Arg Gly His Arg Ala Thr 
            180                 185                 


<210>  1515
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACUL1__Homo_sapiens__NP_722517

<400>  1515

Met Glu Glu Ser Met Glu Glu Glu Glu Gly Gly Ser Tyr Glu Ala Met 
1               5                   10                  15      


Met Asp Asp Gln Asn His Asn Asn Trp Glu Ala Ala Val Asp Gly Phe 
            20                  25                  30          


Arg Gln Pro Leu Pro Pro Pro Pro Pro Pro Ser Ser Ile Pro Ala Pro 
        35                  40                  45              


Ala Arg Glu Pro Pro Gly Gly Gln Leu Leu Ala Val Pro Ala Val Ser 
    50                  55                  60                  


Val Asp Arg Lys Gly Pro Lys Glu Gly Leu Pro Met Gly Pro Gln Pro 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Gly Val Ile Met Met Leu Lys Ser Cys Asp Ala 
                85                  90                  95      


Ala Ala Ala Val Ala Lys Ala Ala Pro Ala Pro Thr Ala Ser Ser Thr 
            100                 105                 110         


Ile Asn Ile Asn Thr Ser Thr Ser Lys Phe Leu Met Asn Val Ile Thr 
        115                 120                 125             


Ile Glu Asp Tyr Lys Ser Thr Tyr Trp Pro Lys Leu Asp Gly Ala Ile 
    130                 135                 140                 


Asp Gln Leu Leu Thr Gln Ser Pro Gly Asp Tyr Ile Pro Ile Ser Tyr 
145                 150                 155                 160 


Glu Gln Ile Tyr Ser Cys Val Tyr Lys Cys Val Cys Gln Gln His Ser 
                165                 170                 175     


Glu Gln Met Tyr Ser Asp Leu Ile Lys Lys Ile Thr Asn His Leu Glu 
            180                 185                 190         


Arg Val Ser Lys Glu Leu Gln Ala Ser Pro Pro Asp Leu Tyr Ile Glu 
        195                 200                 205             


Arg Phe Asn Ile Ala Leu Gly Gln Tyr Met Gly Ala Leu Gln Ser Ile 
    210                 215                 220                 


Val Pro Leu Phe Ile Tyr Met Asn Lys Phe Tyr Ile Glu Thr Lys Leu 
225                 230                 235                 240 


Asn Arg Asp Leu Lys Asp Asp Leu Ile Lys Leu Phe Thr Glu His Val 
                245                 250                 255     


Ala Glu Lys His Ile Tyr Ser Leu Met Pro Leu Leu Leu Glu Ala Gln 
            260                 265                 270         


Ser Thr Pro Phe Gln Val Thr Pro Ser Thr Met Ala Asn Ile Val Lys 
        275                 280                 285             


Gly Leu Tyr Thr Leu Arg Pro Glu Trp Val Gln Met Ala Pro Thr Leu 
    290                 295                 300                 


Phe Ser Lys Phe Ile Pro Asn Ile Leu Pro Pro Ala Val Glu Ser Glu 
305                 310                 315                 320 


Leu Ser Glu Tyr Ala Ala Gln Asp Gln Lys Phe Gln Arg Glu Leu Ile 
                325                 330                 335     


Gln Asn Gly Phe Thr Arg Gly Asp Gln Ser Arg Lys Arg Ala Gly Asp 
            340                 345                 350         


Glu Leu Ala Tyr Asn Ser Ser Ser Ala Cys Ala Ser Ser Arg Gly Tyr 
        355                 360                 365             


Arg 
    


<210>  1516
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CACYBP__Homo_sapiens__NP_001007215

<400>  1516

Met Gln Gln Lys Ser Gln Lys Lys Ala Glu Leu Leu Asp Asn Glu Lys 
1               5                   10                  15      


Pro Ala Ala Val Val Ala Pro Ile Thr Thr Gly Tyr Thr Val Lys Ile 
            20                  25                  30          


Ser Asn Tyr Gly Trp Asp Gln Ser Asp Lys Phe Val Lys Ile Tyr Ile 
        35                  40                  45              


Thr Leu Thr Gly Val His Gln Val Pro Thr Glu Asn Val Gln Val His 
    50                  55                  60                  


Phe Thr Glu Arg Ser Phe Asp Leu Leu Val Lys Asn Leu Asn Gly Lys 
65                  70                  75                  80  


Ser Tyr Ser Met Ile Val Asn Asn Leu Leu Lys Pro Ile Ser Val Glu 
                85                  90                  95      


Gly Ser Ser Lys Lys Val Lys Thr Asp Thr Val Leu Ile Leu Cys Arg 
            100                 105                 110         


Lys Lys Val Glu Asn Thr Arg Trp Asp Tyr Leu Thr Gln Val Glu Lys 
        115                 120                 125             


Glu Cys Lys Glu Lys Glu Lys Pro Ser Tyr Asp Thr Glu Thr Asp Pro 
    130                 135                 140                 


Ser Glu Gly Leu Met Asn Val Leu Lys Lys Ile Tyr Glu Asp Gly Asp 
145                 150                 155                 160 


Asp Asp Met Lys Arg Thr Ile Asn Lys Ala Trp Val Glu Ser Arg Glu 
                165                 170                 175     


Lys Gln Ala Lys Gly Asp Thr Glu Phe 
            180                 185 


<210>  1517
<211>  2225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAD__Homo_sapiens__NP_004332

<400>  1517

Met Ala Ala Leu Val Leu Glu Asp Gly Ser Val Leu Arg Gly Gln Pro 
1               5                   10                  15      


Phe Gly Ala Ala Val Ser Thr Ala Gly Glu Val Val Phe Gln Thr Gly 
            20                  25                  30          


Met Val Gly Tyr Pro Glu Ala Leu Thr Asp Pro Ser Tyr Lys Ala Gln 
        35                  40                  45              


Ile Leu Val Leu Thr Tyr Pro Leu Ile Gly Asn Tyr Gly Ile Pro Pro 
    50                  55                  60                  


Asp Glu Met Asp Glu Phe Gly Leu Cys Lys Trp Phe Glu Ser Ser Gly 
65                  70                  75                  80  


Ile His Val Ala Ala Leu Val Val Gly Glu Cys Cys Pro Thr Pro Ser 
                85                  90                  95      


His Trp Ser Ala Thr Arg Thr Leu His Glu Trp Leu Gln Gln His Gly 
            100                 105                 110         


Ile Pro Gly Leu Gln Gly Val Asp Thr Arg Glu Leu Thr Lys Lys Leu 
        115                 120                 125             


Arg Glu Gln Gly Ser Leu Leu Gly Lys Leu Val Gln Asn Gly Thr Glu 
    130                 135                 140                 


Pro Ser Ser Leu Pro Phe Leu Asp Pro Asn Ala Arg Pro Leu Val Pro 
145                 150                 155                 160 


Glu Val Ser Ile Lys Thr Pro Arg Val Phe Asn Thr Gly Gly Ala Pro 
                165                 170                 175     


Arg Ile Leu Ala Leu Asp Cys Gly Leu Lys Tyr Asn Gln Ile Arg Cys 
            180                 185                 190         


Leu Cys Gln Arg Gly Ala Glu Val Thr Val Val Pro Trp Asp His Ala 
        195                 200                 205             


Leu Asp Ser Gln Glu Tyr Glu Gly Leu Phe Leu Ser Asn Gly Pro Gly 
    210                 215                 220                 


Asp Pro Ala Ser Tyr Pro Ser Val Val Ser Thr Leu Ser Arg Val Leu 
225                 230                 235                 240 


Ser Glu Pro Asn Pro Arg Pro Val Phe Gly Ile Cys Leu Gly His Gln 
                245                 250                 255     


Leu Leu Ala Leu Ala Ile Gly Ala Lys Thr Tyr Lys Met Arg Tyr Gly 
            260                 265                 270         


Asn Arg Gly His Asn Gln Pro Cys Leu Leu Val Gly Ser Gly Arg Cys 
        275                 280                 285             


Phe Leu Thr Ser Gln Asn His Gly Phe Ala Val Glu Thr Asp Ser Leu 
    290                 295                 300                 


Pro Ala Asp Trp Ala Pro Leu Phe Thr Asn Ala Asn Asp Gly Ser Asn 
305                 310                 315                 320 


Glu Gly Ile Val His Asn Ser Leu Pro Phe Phe Ser Val Gln Phe His 
                325                 330                 335     


Pro Glu His Gln Ala Gly Pro Ser Asp Met Glu Leu Leu Phe Asp Ile 
            340                 345                 350         


Phe Leu Glu Thr Val Lys Glu Ala Thr Ala Gly Asn Pro Gly Gly Gln 
        355                 360                 365             


Thr Val Arg Glu Arg Leu Thr Glu Arg Leu Cys Pro Pro Gly Ile Pro 
    370                 375                 380                 


Thr Pro Gly Ser Gly Leu Pro Pro Pro Arg Lys Val Leu Ile Leu Gly 
385                 390                 395                 400 


Ser Gly Gly Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly 
                405                 410                 415     


Ser Gln Ala Ile Lys Ala Leu Lys Glu Glu Asn Ile Gln Thr Leu Leu 
            420                 425                 430         


Ile Asn Pro Asn Ile Ala Thr Val Gln Thr Ser Gln Gly Leu Ala Asp 
        435                 440                 445             


Lys Val Tyr Phe Leu Pro Ile Thr Pro His Tyr Val Thr Gln Val Ile 
    450                 455                 460                 


Arg Asn Glu Arg Pro Asp Gly Val Leu Leu Thr Phe Gly Gly Gln Thr 
465                 470                 475                 480 


Ala Leu Asn Cys Gly Val Glu Leu Thr Lys Ala Gly Val Leu Ala Arg 
                485                 490                 495     


Tyr Gly Val Arg Val Leu Gly Thr Pro Val Glu Thr Ile Glu Leu Thr 
            500                 505                 510         


Glu Asp Arg Arg Ala Phe Ala Ala Arg Met Ala Glu Ile Gly Glu His 
        515                 520                 525             


Val Ala Pro Ser Glu Ala Ala Asn Ser Leu Glu Gln Ala Gln Ala Ala 
    530                 535                 540                 


Ala Glu Arg Leu Gly Tyr Pro Val Leu Val Arg Ala Ala Phe Ala Leu 
545                 550                 555                 560 


Gly Gly Leu Gly Ser Gly Phe Ala Ser Asn Arg Glu Glu Leu Ser Ala 
                565                 570                 575     


Leu Val Ala Pro Ala Phe Ala His Thr Ser Gln Val Leu Val Asp Lys 
            580                 585                 590         


Ser Leu Lys Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 
        595                 600                 605             


Tyr Gly Asn Cys Val Thr Val Cys Asn Met Glu Asn Leu Asp Pro Leu 
    610                 615                 620                 


Gly Ile His Thr Gly Glu Ser Ile Val Val Ala Pro Ser Gln Thr Leu 
625                 630                 635                 640 


Asn Asp Arg Glu Tyr Gln Leu Leu Arg Gln Thr Ala Ile Lys Val Thr 
                645                 650                 655     


Gln His Leu Gly Ile Val Gly Glu Cys Asn Val Gln Tyr Ala Leu Asn 
            660                 665                 670         


Pro Glu Ser Glu Gln Tyr Tyr Ile Ile Glu Val Asn Ala Arg Leu Ser 
        675                 680                 685             


Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Tyr 
    690                 695                 700                 


Val Ala Ala Lys Leu Ala Leu Gly Ile Pro Leu Pro Glu Leu Arg Asn 
705                 710                 715                 720 


Ser Val Thr Gly Gly Thr Ala Ala Phe Glu Pro Ser Val Asp Tyr Cys 
                725                 730                 735     


Val Val Lys Ile Pro Arg Trp Asp Leu Ser Lys Phe Leu Arg Val Ser 
            740                 745                 750         


Thr Lys Ile Gly Ser Cys Met Lys Ser Val Gly Glu Val Met Gly Ile 
        755                 760                 765             


Gly Arg Ser Phe Glu Glu Ala Phe Gln Lys Ala Leu Arg Met Val Asp 
    770                 775                 780                 


Glu Asn Cys Val Gly Phe Asp His Thr Val Lys Pro Val Ser Asp Met 
785                 790                 795                 800 


Glu Leu Glu Thr Pro Thr Asp Lys Arg Ile Phe Val Val Ala Ala Ala 
                805                 810                 815     


Leu Trp Ala Gly Tyr Ser Val Asp Arg Leu Tyr Glu Leu Thr Arg Ile 
            820                 825                 830         


Asp Arg Trp Phe Leu His Arg Met Lys Arg Ile Ile Ala His Ala Gln 
        835                 840                 845             


Leu Leu Glu Gln His Arg Gly Gln Pro Leu Pro Pro Asp Leu Leu Gln 
    850                 855                 860                 


Gln Ala Lys Cys Leu Gly Phe Ser Asp Lys Gln Ile Ala Leu Ala Val 
865                 870                 875                 880 


Leu Ser Thr Glu Leu Ala Val Arg Lys Leu Arg Gln Glu Leu Gly Ile 
                885                 890                 895     


Cys Pro Ala Val Lys Gln Ile Asp Thr Val Ala Ala Glu Trp Pro Ala 
            900                 905                 910         


Gln Thr Asn Tyr Leu Tyr Leu Thr Tyr Trp Gly Thr Thr His Asp Leu 
        915                 920                 925             


Thr Phe Arg Thr Pro His Val Leu Val Leu Gly Ser Gly Val Tyr Arg 
    930                 935                 940                 


Ile Gly Ser Ser Val Glu Phe Asp Trp Cys Ala Val Gly Cys Ile Gln 
945                 950                 955                 960 


Gln Leu Arg Lys Met Gly Tyr Lys Thr Ile Met Val Asn Tyr Asn Pro 
                965                 970                 975     


Glu Thr Val Ser Thr Asp Tyr Asp Met Cys Asp Arg Leu Tyr Phe Asp 
            980                 985                 990         


Glu Ile Ser Phe Glu Val Val Met  Asp Ile Tyr Glu Leu  Glu Asn Pro 
        995                 1000                 1005             


Glu Gly  Val Ile Leu Ser Met  Gly Gly Gln Leu Pro  Asn Asn Met 
    1010                 1015                 1020             


Ala Met  Ala Leu His Arg Gln  Gln Cys Arg Val Leu  Gly Thr Ser 
    1025                 1030                 1035             


Pro Glu  Ala Ile Asp Ser Ala  Glu Asn Arg Phe Lys  Phe Ser Arg 
    1040                 1045                 1050             


Leu Leu  Asp Thr Ile Gly Ile  Ser Gln Pro Gln Trp  Arg Glu Leu 
    1055                 1060                 1065             


Ser Asp  Leu Glu Ser Ala Arg  Gln Phe Cys Gln Thr  Val Gly Tyr 
    1070                 1075                 1080             


Pro Cys  Val Val Arg Pro Ser  Tyr Val Leu Ser Gly  Ala Ala Met 
    1085                 1090                 1095             


Asn Val  Ala Tyr Thr Asp Gly  Asp Leu Glu Arg Phe  Leu Ser Ser 
    1100                 1105                 1110             


Ala Ala  Ala Val Ser Lys Glu  His Pro Val Val Ile  Ser Lys Phe 
    1115                 1120                 1125             


Ile Gln  Glu Ala Lys Glu Ile  Asp Val Asp Ala Val  Ala Ser Asp 
    1130                 1135                 1140             


Gly Val  Val Ala Ala Ile Ala  Ile Ser Glu His Val  Glu Asn Ala 
    1145                 1150                 1155             


Gly Val  His Ser Gly Asp Ala  Thr Leu Val Thr Pro  Pro Gln Asp 
    1160                 1165                 1170             


Ile Thr  Ala Lys Thr Leu Glu  Arg Ile Lys Ala Ile  Val His Ala 
    1175                 1180                 1185             


Val Gly  Gln Glu Leu Gln Val  Thr Gly Pro Phe Asn  Leu Gln Leu 
    1190                 1195                 1200             


Ile Ala  Lys Asp Asp Gln Leu  Lys Val Ile Glu Cys  Asn Val Arg 
    1205                 1210                 1215             


Val Ser  Arg Ser Phe Pro Phe  Val Ser Lys Thr Leu  Gly Val Asp 
    1220                 1225                 1230             


Leu Val  Ala Leu Ala Thr Arg  Val Ile Met Gly Glu  Glu Val Glu 
    1235                 1240                 1245             


Pro Val  Gly Leu Met Thr Gly  Ser Gly Val Val Gly  Val Lys Val 
    1250                 1255                 1260             


Pro Gln  Phe Ser Phe Ser Arg  Leu Ala Gly Ala Asp  Val Val Leu 
    1265                 1270                 1275             


Gly Val  Glu Met Thr Ser Thr  Gly Glu Val Ala Gly  Phe Gly Glu 
    1280                 1285                 1290             


Ser Arg  Cys Glu Ala Tyr Leu  Lys Ala Met Leu Ser  Thr Gly Phe 
    1295                 1300                 1305             


Lys Ile  Pro Lys Lys Asn Ile  Leu Leu Thr Ile Gly  Ser Tyr Lys 
    1310                 1315                 1320             


Asn Lys  Ser Glu Leu Leu Pro  Thr Val Arg Leu Leu  Glu Ser Leu 
    1325                 1330                 1335             


Gly Tyr  Ser Leu Tyr Ala Ser  Leu Gly Thr Ala Asp  Phe Tyr Thr 
    1340                 1345                 1350             


Glu His  Gly Val Lys Val Thr  Ala Val Asp Trp His  Phe Glu Glu 
    1355                 1360                 1365             


Ala Val  Asp Gly Glu Cys Pro  Pro Gln Arg Ser Ile  Leu Glu Gln 
    1370                 1375                 1380             


Leu Ala  Glu Lys Asn Phe Glu  Leu Val Ile Asn Leu  Ser Met Arg 
    1385                 1390                 1395             


Gly Ala  Gly Gly Arg Arg Leu  Ser Ser Phe Val Thr  Lys Gly Tyr 
    1400                 1405                 1410             


Arg Thr  Arg Arg Leu Ala Ala  Asp Phe Ser Val Pro  Leu Ile Ile 
    1415                 1420                 1425             


Asp Ile  Lys Cys Thr Lys Leu  Phe Val Glu Ala Leu  Gly Gln Ile 
    1430                 1435                 1440             


Gly Pro  Ala Pro Pro Leu Lys  Val His Val Asp Cys  Met Thr Ser 
    1445                 1450                 1455             


Gln Lys  Leu Val Arg Leu Pro  Gly Leu Ile Asp Val  His Val His 
    1460                 1465                 1470             


Leu Arg  Glu Pro Gly Gly Thr  His Lys Glu Asp Phe  Ala Ser Gly 
    1475                 1480                 1485             


Thr Ala  Ala Ala Leu Ala Gly  Gly Ile Thr Met Val  Cys Ala Met 
    1490                 1495                 1500             


Pro Asn  Thr Arg Pro Pro Ile  Ile Asp Ala Pro Ala  Leu Ala Leu 
    1505                 1510                 1515             


Ala Gln  Lys Leu Ala Glu Ala  Gly Ala Arg Cys Asp  Phe Ala Leu 
    1520                 1525                 1530             


Phe Leu  Gly Ala Ser Ser Glu  Asn Ala Gly Thr Leu  Gly Thr Val 
    1535                 1540                 1545             


Ala Gly  Ser Ala Ala Gly Leu  Lys Leu Tyr Leu Asn  Glu Thr Phe 
    1550                 1555                 1560             


Ser Glu  Leu Arg Leu Asp Ser  Val Val Gln Trp Met  Glu His Phe 
    1565                 1570                 1575             


Glu Thr  Trp Pro Ser His Leu  Pro Ile Val Ala His  Ala Glu Gln 
    1580                 1585                 1590             


Gln Thr  Val Ala Ala Val Leu  Met Val Ala Gln Leu  Thr Gln Arg 
    1595                 1600                 1605             


Ser Val  His Ile Cys His Val  Ala Arg Lys Glu Glu  Ile Leu Leu 
    1610                 1615                 1620             


Ile Lys  Ala Ala Lys Ala Arg  Gly Leu Pro Val Thr  Cys Glu Val 
    1625                 1630                 1635             


Ala Pro  His His Leu Phe Leu  Ser His Asp Asp Leu  Glu Arg Leu 
    1640                 1645                 1650             


Gly Pro  Gly Lys Gly Glu Val  Arg Pro Glu Leu Gly  Ser Arg Gln 
    1655                 1660                 1665             


Asp Val  Glu Ala Leu Trp Glu  Asn Met Ala Val Ile  Asp Cys Phe 
    1670                 1675                 1680             


Ala Ser  Asp His Ala Pro His  Thr Leu Glu Glu Lys  Cys Gly Ser 
    1685                 1690                 1695             


Arg Pro  Pro Pro Gly Phe Pro  Gly Leu Glu Thr Met  Leu Pro Leu 
    1700                 1705                 1710             


Leu Leu  Thr Ala Val Ser Glu  Gly Arg Leu Ser Leu  Asp Asp Leu 
    1715                 1720                 1725             


Leu Gln  Arg Leu His His Asn  Pro Arg Arg Ile Phe  His Leu Pro 
    1730                 1735                 1740             


Pro Gln  Glu Asp Thr Tyr Val  Glu Val Asp Leu Glu  His Glu Trp 
    1745                 1750                 1755             


Thr Ile  Pro Ser His Met Pro  Phe Ser Lys Ala His  Trp Thr Pro 
    1760                 1765                 1770             


Phe Glu  Gly Gln Lys Val Lys  Gly Thr Val Arg Arg  Val Val Leu 
    1775                 1780                 1785             


Arg Gly  Glu Val Ala Tyr Ile  Asp Gly Gln Val Leu  Val Pro Pro 
    1790                 1795                 1800             


Gly Tyr  Gly Gln Asp Val Arg  Lys Trp Pro Gln Gly  Ala Val Pro 
    1805                 1810                 1815             


Gln Leu  Pro Pro Ser Ala Pro  Ala Thr Ser Glu Met  Thr Thr Thr 
    1820                 1825                 1830             


Pro Glu  Arg Pro Arg Arg Gly  Ile Pro Gly Leu Pro  Asp Gly Arg 
    1835                 1840                 1845             


Phe His  Leu Pro Pro Arg Ile  His Arg Ala Ser Asp  Pro Gly Leu 
    1850                 1855                 1860             


Pro Ala  Glu Glu Pro Lys Glu  Lys Ser Ser Arg Lys  Val Ala Glu 
    1865                 1870                 1875             


Pro Glu  Leu Met Gly Thr Pro  Asp Gly Thr Cys Tyr  Pro Pro Pro 
    1880                 1885                 1890             


Pro Val  Pro Arg Gln Ala Ser  Pro Gln Asn Leu Gly  Thr Pro Gly 
    1895                 1900                 1905             


Leu Leu  His Pro Gln Thr Ser  Pro Leu Leu His Ser  Leu Val Gly 
    1910                 1915                 1920             


Gln His  Ile Leu Ser Val Gln  Gln Phe Thr Lys Asp  Gln Met Ser 
    1925                 1930                 1935             


His Leu  Phe Asn Val Ala His  Thr Leu Arg Met Met  Val Gln Lys 
    1940                 1945                 1950             


Glu Arg  Ser Leu Asp Ile Leu  Lys Gly Lys Val Met  Ala Ser Met 
    1955                 1960                 1965             


Phe Tyr  Glu Val Ser Thr Arg  Thr Ser Ser Ser Phe  Ala Ala Ala 
    1970                 1975                 1980             


Met Ala  Arg Leu Gly Gly Ala  Val Leu Ser Phe Ser  Glu Ala Thr 
    1985                 1990                 1995             


Ser Ser  Val Gln Lys Gly Glu  Ser Leu Ala Asp Ser  Val Gln Thr 
    2000                 2005                 2010             


Met Ser  Cys Tyr Ala Asp Val  Val Val Leu Arg His  Pro Gln Pro 
    2015                 2020                 2025             


Gly Ala  Val Glu Leu Ala Ala  Lys His Cys Arg Arg  Pro Val Ile 
    2030                 2035                 2040             


Asn Ala  Gly Asp Gly Val Gly  Glu His Pro Thr Gln  Ala Leu Leu 
    2045                 2050                 2055             


Asp Ile  Phe Thr Ile Arg Glu  Glu Leu Gly Thr Val  Asn Gly Met 
    2060                 2065                 2070             


Thr Ile  Thr Met Val Gly Asp  Leu Lys His Gly Arg  Thr Val His 
    2075                 2080                 2085             


Ser Leu  Ala Cys Leu Leu Thr  Gln Tyr Arg Val Ser  Leu Arg Tyr 
    2090                 2095                 2100             


Val Ala  Pro Pro Ser Leu Arg  Met Pro Pro Thr Val  Arg Ala Phe 
    2105                 2110                 2115             


Val Ala  Ser Arg Gly Thr Lys  Gln Glu Glu Phe Glu  Ser Ile Glu 
    2120                 2125                 2130             


Glu Ala  Leu Pro Asp Thr Asp  Val Leu Tyr Met Thr  Arg Ile Gln 
    2135                 2140                 2145             


Lys Glu  Arg Phe Gly Ser Thr  Gln Glu Tyr Glu Ala  Cys Phe Gly 
    2150                 2155                 2160             


Gln Phe  Ile Leu Thr Pro His  Ile Met Thr Arg Ala  Lys Lys Lys 
    2165                 2170                 2175             


Met Val  Val Met His Pro Met  Pro Arg Val Asn Glu  Ile Ser Val 
    2180                 2185                 2190             


Glu Val  Asp Ser Asp Pro Arg  Ala Ala Tyr Phe Arg  Gln Ala Glu 
    2195                 2200                 2205             


Asn Gly  Met Tyr Ile Arg Met  Ala Leu Leu Ala Thr  Val Leu Gly 
    2210                 2215                 2220             


Arg Phe  
    2225 


<210>  1518
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CADM1__Homo_sapiens__NP_001091987

<400>  1518

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Ser Arg Ala Gly 
                325                 330                 335     


Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val 
            340                 345                 350         


Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly 
        355                 360                 365             


Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys 
    370                 375                 380                 


Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
385                 390                 395                 400 


Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
                405                 410                 


<210>  1519
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CADM2__Homo_sapiens__NP_001161146

<400>  1519

Met Ile Trp Lys Arg Ser Ala Val Leu Arg Phe Tyr Ser Val Cys Gly 
1               5                   10                  15      


Leu Leu Leu Gln Gly Ser Gln Gly Gln Phe Pro Leu Thr Gln Asn Val 
            20                  25                  30          


Thr Val Val Glu Gly Gly Thr Ala Ile Leu Thr Cys Arg Val Asp Gln 
        35                  40                  45              


Asn Asp Asn Thr Ser Leu Gln Trp Ser Asn Pro Ala Gln Gln Thr Leu 
    50                  55                  60                  


Tyr Phe Asp Asp Lys Lys Ala Leu Arg Asp Asn Arg Ile Glu Leu Val 
65                  70                  75                  80  


Arg Ala Ser Trp His Glu Leu Ser Ile Ser Val Ser Asp Val Ser Leu 
                85                  90                  95      


Ser Asp Glu Gly Gln Tyr Thr Cys Ser Leu Phe Thr Met Pro Val Lys 
            100                 105                 110         


Thr Ser Lys Ala Tyr Leu Thr Val Leu Gly Val Pro Glu Lys Pro Gln 
        115                 120                 125             


Ile Ser Gly Phe Ser Ser Pro Val Met Glu Gly Asp Leu Met Gln Leu 
    130                 135                 140                 


Thr Cys Lys Thr Ser Gly Ser Lys Pro Ala Ala Asp Ile Arg Trp Phe 
145                 150                 155                 160 


Lys Asn Asp Lys Glu Ile Lys Asp Val Lys Tyr Leu Lys Glu Glu Asp 
                165                 170                 175     


Ala Asn Arg Lys Thr Phe Thr Val Ser Ser Thr Leu Asp Phe Arg Val 
            180                 185                 190         


Asp Arg Ser Asp Asp Gly Val Ala Val Ile Cys Arg Val Asp His Glu 
        195                 200                 205             


Ser Leu Asn Ala Thr Pro Gln Val Ala Met Gln Val Leu Glu Ile His 
    210                 215                 220                 


Tyr Thr Pro Ser Val Lys Ile Ile Pro Ser Thr Pro Phe Pro Gln Glu 
225                 230                 235                 240 


Gly Gln Pro Leu Ile Leu Thr Cys Glu Ser Lys Gly Lys Pro Leu Pro 
                245                 250                 255     


Glu Pro Val Leu Trp Thr Lys Asp Gly Gly Glu Leu Pro Asp Pro Asp 
            260                 265                 270         


Arg Met Val Val Ser Gly Arg Glu Leu Asn Ile Leu Phe Leu Asn Lys 
        275                 280                 285             


Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Thr Asn Thr Ile Gly Gln 
    290                 295                 300                 


Ser Ser Ala Glu Tyr Val Leu Ile Val His Asp Val Pro Asn Thr Leu 
305                 310                 315                 320 


Leu Pro Thr Thr Ile Ile Pro Ser Leu Thr Thr Ala Thr Val Thr Thr 
                325                 330                 335     


Thr Val Ala Ile Thr Thr Ser Pro Thr Thr Ser Ala Thr Thr Ser Ser 
            340                 345                 350         


Ile Arg Asp Pro Asn Ala Leu Ala Gly Gln Asn Gly Pro Asp His Ala 
        355                 360                 365             


Leu Ile Gly Gly Ile Val Ala Val Val Val Phe Val Thr Leu Cys Ser 
    370                 375                 380                 


Ile Phe Leu Leu Gly Arg Tyr Leu Ala Arg His Lys Gly Thr Tyr Leu 
385                 390                 395                 400 


Thr Asn Glu Ala Lys Gly Ala Glu Asp Ala Pro Asp Ala Asp Thr Ala 
                405                 410                 415     


Ile Ile Asn Ala Glu Gly Ser Gln Val Asn Ala Glu Glu Lys Lys Glu 
            420                 425                 430         


Tyr Phe Ile 
        435 


<210>  1520
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CADM3__Homo_sapiens__NP_001120645

<400>  1520

Met Gly Ala Pro Ala Ala Ser Leu Leu Leu Leu Leu Leu Leu Phe Ala 
1               5                   10                  15      


Cys Cys Trp Ala Pro Gly Gly Ala Asn Leu Ser Gln Asp Asp Ser Gln 
            20                  25                  30          


Pro Trp Thr Ser Asp Glu Thr Val Val Ala Gly Gly Thr Val Val Leu 
        35                  40                  45              


Lys Cys Gln Val Lys Asp His Glu Asp Ser Ser Leu Gln Trp Ser Asn 
    50                  55                  60                  


Pro Ala Gln Gln Thr Leu Tyr Phe Gly Glu Lys Arg Ala Leu Arg Asp 
65                  70                  75                  80  


Asn Arg Ile Gln Leu Val Thr Ser Thr Pro His Glu Leu Ser Ile Ser 
                85                  90                  95      


Ile Ser Asn Val Ala Leu Ala Asp Glu Gly Glu Tyr Thr Cys Ser Ile 
            100                 105                 110         


Phe Thr Met Pro Val Arg Thr Ala Lys Ser Leu Val Thr Val Leu Gly 
        115                 120                 125             


Ile Pro Gln Lys Pro Ile Ile Thr Gly Tyr Lys Ser Ser Leu Arg Glu 
    130                 135                 140                 


Lys Asp Thr Ala Thr Leu Asn Cys Gln Ser Ser Gly Ser Lys Pro Ala 
145                 150                 155                 160 


Ala Arg Leu Thr Trp Arg Lys Gly Asp Gln Glu Leu His Gly Glu Pro 
                165                 170                 175     


Thr Arg Ile Gln Glu Asp Pro Asn Gly Lys Thr Phe Thr Val Ser Ser 
            180                 185                 190         


Ser Val Thr Phe Gln Val Thr Arg Glu Asp Asp Gly Ala Ser Ile Val 
        195                 200                 205             


Cys Ser Val Asn His Glu Ser Leu Lys Gly Ala Asp Arg Ser Thr Ser 
    210                 215                 220                 


Gln Arg Ile Glu Val Leu Tyr Thr Pro Thr Ala Met Ile Arg Pro Asp 
225                 230                 235                 240 


Pro Pro His Pro Arg Glu Gly Gln Lys Leu Leu Leu His Cys Glu Gly 
                245                 250                 255     


Arg Gly Asn Pro Val Pro Gln Gln Tyr Leu Trp Glu Lys Glu Gly Ser 
            260                 265                 270         


Val Pro Pro Leu Lys Met Thr Gln Glu Ser Ala Leu Ile Phe Pro Phe 
        275                 280                 285             


Leu Asn Lys Ser Asp Ser Gly Thr Tyr Gly Cys Thr Ala Thr Ser Asn 
    290                 295                 300                 


Met Gly Ser Tyr Lys Ala Tyr Tyr Thr Leu Asn Val Asn Asp Pro Ser 
305                 310                 315                 320 


Pro Val Pro Ser Ser Ser Ser Thr Tyr His Ala Ile Ile Gly Gly Ile 
                325                 330                 335     


Val Ala Phe Ile Val Phe Leu Leu Leu Ile Met Leu Ile Phe Leu Gly 
            340                 345                 350         


His Tyr Leu Ile Arg His Lys Gly Thr Tyr Leu Thr His Glu Ala Lys 
        355                 360                 365             


Gly Ser Asp Asp Ala Pro Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu 
    370                 375                 380                 


Gly Gly Gln Ser Gly Gly Asp Asp Lys Lys Glu Tyr Phe Ile 
385                 390                 395             


<210>  1521
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CADM4__Homo_sapiens__NP_660339

<400>  1521

Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala 
1               5                   10                  15      


Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val 
            20                  25                  30          


Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln 
        35                  40                  45              


Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu 
    50                  55                  60                  


Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu 
65                  70                  75                  80  


Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu 
                85                  90                  95      


Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His 
            100                 105                 110         


His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val 
        115                 120                 125             


Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser 
    130                 135                 140                 


Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg 
145                 150                 155                 160 


Asp Arg Lys Glu Leu Lys Gly Val Ser Ser Ser Gln Glu Asn Gly Lys 
                165                 170                 175     


Val Trp Ser Val Ala Ser Thr Val Arg Phe Arg Val Asp Arg Lys Asp 
            180                 185                 190         


Asp Gly Gly Ile Ile Ile Cys Glu Ala Gln Asn Gln Ala Leu Pro Ser 
        195                 200                 205             


Gly His Ser Lys Gln Thr Gln Tyr Val Leu Asp Val Gln Tyr Ser Pro 
    210                 215                 220                 


Thr Ala Arg Ile His Ala Ser Gln Ala Val Val Arg Glu Gly Asp Thr 
225                 230                 235                 240 


Leu Val Leu Thr Cys Ala Val Thr Gly Asn Pro Arg Pro Asn Gln Ile 
                245                 250                 255     


Arg Trp Asn Arg Gly Asn Glu Ser Leu Pro Glu Arg Ala Glu Ala Val 
            260                 265                 270         


Gly Glu Thr Leu Thr Leu Pro Gly Leu Val Ser Ala Asp Asn Gly Thr 
        275                 280                 285             


Tyr Thr Cys Glu Ala Ser Asn Lys His Gly His Ala Arg Ala Leu Tyr 
    290                 295                 300                 


Val Leu Val Val Tyr Asp Pro Gly Ala Val Val Glu Ala Gln Thr Ser 
305                 310                 315                 320 


Val Pro Tyr Ala Ile Val Gly Gly Ile Leu Ala Leu Leu Val Phe Leu 
                325                 330                 335     


Ile Ile Cys Val Leu Val Gly Met Val Trp Cys Ser Val Arg Gln Lys 
            340                 345                 350         


Gly Ser Tyr Leu Thr His Glu Ala Ser Gly Leu Asp Glu Gln Gly Glu 
        355                 360                 365             


Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp Gly His Lys Arg Lys Glu 
    370                 375                 380                 


Glu Phe Phe Ile 
385             


<210>  1522
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CADPS2__Homo_sapiens__NP_001009571

<400>  1522

Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Gly Leu Glu 
1               5                   10                  15      


Glu Glu Ser Arg Asp Val Leu Val Ala Ala Gly Ser Ser Gln Arg Ala 
            20                  25                  30          


Pro Pro Ala Pro Thr Arg Glu Gly Arg Arg Asp Ala Pro Gly Arg Ala 
        35                  40                  45              


Gly Gly Gly Gly Ala Ala Arg Ser Val Ser Pro Ser Pro Ser Val Leu 
    50                  55                  60                  


Ser Glu Gly Arg Asp Glu Pro Gln Arg Gln Leu Asp Asp Glu Gln Glu 
65                  70                  75                  80  


Arg Arg Ile Arg Leu Gln Leu Tyr Val Phe Val Val Arg Cys Ile Ala 
                85                  90                  95      


Tyr Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg Gln Gln 
            100                 105                 110         


Lys Leu Asn Lys Gln Gln Leu Gln Leu Leu Lys Glu Arg Phe Gln Ala 
        115                 120                 125             


Phe Leu Asn Gly Glu Thr Gln Ile Val Ala Asp Glu Ala Phe Cys Asn 
    130                 135                 140                 


Ala Val Arg Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg Val Ala 
145                 150                 155                 160 


Arg Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Phe Arg Glu Val 
                165                 170                 175     


Phe Lys Lys Asn Ile Glu Lys Arg Val Arg Ser Leu Pro Glu Ile Asp 
            180                 185                 190         


Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Ile Ala Lys Tyr Asp 
        195                 200                 205             


Ala Ile Tyr Arg Gly Glu Glu Asp Leu Cys Lys Gln Pro Asn Arg Met 
    210                 215                 220                 


Ala Leu Ser Ala Val Ser Glu Leu Ile Leu Ser Lys Glu Gln Leu Tyr 
225                 230                 235                 240 


Glu Met Phe Gln Gln Ile Leu Gly Ile Lys Lys Leu Glu His Gln Leu 
                245                 250                 255     


Leu Tyr Asn Ala Cys Gln Leu Asp Asn Ala Asp Glu Gln Ala Ala Gln 
            260                 265                 270         


Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Leu Ala Asp Lys Met Ala 
        275                 280                 285             


Lys Glu Arg Lys Phe Pro Lys Phe Ile Ala Lys Asp Met Glu Asn Met 
    290                 295                 300                 


Tyr Ile Glu Glu Leu Arg Ser Ser Val Asn Leu Leu Met Ala Asn Leu 
305                 310                 315                 320 


Glu Ser Leu Pro Val Ser Lys Gly Gly Pro Glu Phe Lys Leu Gln Lys 
                325                 330                 335     


Leu Lys Arg Ser Gln Asn Ser Ala Phe Leu Asp Ile Gly Asp Glu Asn 
            340                 345                 350         


Glu Ile Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Thr Leu Glu 
        355                 360                 365             


Ile Val Ile Met Glu Val Gln Gly Leu Lys Ser Val Ala Pro Asn Arg 
    370                 375                 380                 


Ile Val Tyr Cys Thr Met Glu Val Glu Gly Glu Lys Leu Gln Thr Asp 
385                 390                 395                 400 


Gln Ala Glu Ala Ser Arg Pro Gln Trp Gly Thr Gln Gly Asp Phe Thr 
                405                 410                 415     


Thr Thr His Pro Arg Pro Val Val Lys Val Lys Leu Phe Thr Glu Ser 
            420                 425                 430         


Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val Ile Leu 
        435                 440                 445             


Tyr Pro Thr Ser Asn Ser Ser Lys Ser Ala Glu Leu His Arg Met Val 
    450                 455                 460                 


Val Pro Lys Asn Ser Gln Asp Ser Asp Leu Lys Ile Lys Leu Ala Val 
465                 470                 475                 480 


Arg Met Asp Lys Pro Ala His Met Lys His Ser Gly Tyr Leu Tyr Ala 
                485                 490                 495     


Leu Gly Gln Lys Val Trp Lys Arg Trp Lys Lys Arg Tyr Phe Val Leu 
            500                 505                 510         


Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg Glu Lys 
        515                 520                 525             


Lys Ser Glu Pro Gln Glu Leu Met Gln Leu Glu Gly Tyr Thr Val Asp 
    530                 535                 540                 


Tyr Thr Asp Pro His Pro Gly Leu Gln Gly Gly Cys Met Phe Phe Asn 
545                 550                 555                 560 


Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp Glu Gln 
                565                 570                 575     


Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly Gln Ser 
            580                 585                 590         


Tyr Lys Pro Val Pro Ala Ile Gln Thr Gln Lys Leu Asn Pro Lys Gly 
        595                 600                 605             


Gly Thr Leu His Ala Asp Ala Gln Leu Tyr Ala Asp Arg Phe Gln Lys 
    610                 615                 620                 


His Gly Met Asp Glu Phe Ile Ser Ala Asn Pro Cys Lys Leu Asp His 
625                 630                 635                 640 


Ala Phe Leu Phe Arg Ile Leu Gln Arg Gln Thr Leu Asp His Arg Leu 
                645                 650                 655     


Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro Gly Gln Val Phe 
            660                 665                 670         


Val Leu Asp Glu Tyr Cys Ala Arg Tyr Gly Val Arg Gly Cys His Arg 
        675                 680                 685             


His Leu Cys Tyr Leu Ala Glu Leu Met Glu His Ser Glu Asn Gly Ala 
    690                 695                 700                 


Val Ile Asp Pro Thr Leu Leu His Tyr Ser Phe Ala Phe Cys Ala Ser 
705                 710                 715                 720 


His Val His Gly Asn Arg Pro Asp Gly Ile Gly Thr Val Ser Val Glu 
                725                 730                 735     


Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg Leu Ser Ser Leu Leu 
            740                 745                 750         


Glu Asn Gln Ile Ser His Phe Arg Tyr Cys Phe Pro Phe Gly Arg Pro 
        755                 760                 765             


Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu Glu Arg Val Leu Met 
    770                 775                 780                 


Lys Asp Ile Ala Thr Pro Ile Pro Ala Glu Glu Val Lys Lys Val Val 
785                 790                 795                 800 


Arg Lys Cys Leu Glu Lys Ala Ala Leu Ile Asn Tyr Thr Arg Leu Thr 
                805                 810                 815     


Glu Tyr Ala Lys Ile Glu Glu Thr Met Asn Gln Ala Ser Pro Ala Arg 
            820                 825                 830         


Lys Leu Glu Glu Ile Leu His Leu Ala Glu Leu Cys Ile Glu Val Leu 
        835                 840                 845             


Gln Gln Asn Glu Glu His His Ala Glu Ala Phe Ala Trp Trp Pro Asp 
    850                 855                 860                 


Leu Leu Ala Glu His Ala Glu Lys Phe Trp Ala Leu Phe Thr Val Asp 
865                 870                 875                 880 


Met Asp Thr Ala Leu Glu Ala Gln Pro Gln Asp Ser Trp Asp Ser Phe 
                885                 890                 895     


Pro Leu Phe Gln Leu Leu Asn Asn Phe Leu Arg Asn Asp Thr Leu Leu 
            900                 905                 910         


Cys Asn Gly Lys Phe His Lys His Leu Gln Glu Ile Phe Val Pro Leu 
        915                 920                 925             


Val Val Arg Tyr Val Asp Leu Met Glu Ser Ser Ile Ala Gln Ser Ile 
    930                 935                 940                 


His Arg Gly Phe Glu Gln Glu Thr Trp Gln Pro Val Asn Asn Gly Ser 
945                 950                 955                 960 


Ala Thr Ser Glu Asp Leu Phe Trp Lys Leu Asp Ala Leu Gln Met Phe 
                965                 970                 975     


Val Phe Asp Leu His Trp Pro Glu Gln Glu Phe Ala His His Leu Glu 
            980                 985                 990         


Gln Arg Leu Lys Leu Met Ala Ser  Asp Met Leu Glu Ala  Cys Val Lys 
        995                 1000                 1005             


Arg Thr  Arg Thr Ala Phe Glu  Leu Lys Leu Gln Lys  Ala Ser Lys 
    1010                 1015                 1020             


Thr Thr  Asp Leu Arg Ile Pro  Ala Ser Val Cys Thr  Met Phe Asn 
    1025                 1030                 1035             


Val Leu  Val Asp Ala Lys Lys  Gln Ser Thr Lys Leu  Cys Ala Leu 
    1040                 1045                 1050             


Asp Gly  Gly Gln Glu Phe Gly  Ser Gln Trp Gln Gln  Tyr His Ser 
    1055                 1060                 1065             


Lys Ile  Asp Asp Leu Ile Asp  Asn Ser Val Lys Glu  Ile Ile Ser 
    1070                 1075                 1080             


Leu Leu  Val Ser Lys Phe Val  Ser Val Leu Glu Gly  Val Leu Ser 
    1085                 1090                 1095             


Lys Leu  Ser Arg Tyr Asp Glu  Gly Thr Phe Phe Ser  Ser Ile Leu 
    1100                 1105                 1110             


Ser Phe  Thr Val Lys Ala Ala  Ala Lys Tyr Val Asp  Val Pro Lys 
    1115                 1120                 1125             


Pro Gly  Met Asp Leu Ala Asp  Thr Tyr Ile Met Phe  Val Arg Gln 
    1130                 1135                 1140             


Asn Gln  Asp Ile Leu Arg Glu  Lys Val Asn Glu Glu  Met Tyr Ile 
    1145                 1150                 1155             


Glu Lys  Leu Phe Asp Gln Trp  Tyr Ser Ser Ser Met  Lys Val Ile 
    1160                 1165                 1170             


Cys Val  Trp Leu Thr Asp Arg  Leu Asp Leu Gln Leu  His Ile Tyr 
    1175                 1180                 1185             


Gln Leu  Lys Thr Leu Ile Lys  Ile Val Lys Lys Thr  Tyr Arg Asp 
    1190                 1195                 1200             


Phe Arg  Leu Gln Gly Val Leu  Glu Gly Thr Leu Asn  Ser Lys Thr 
    1205                 1210                 1215             


Tyr Asp  Thr Val His Arg Arg  Leu Thr Val Glu Glu  Ala Thr Ala 
    1220                 1225                 1230             


Ser Val  Ser Glu Gly Gly Gly  Leu Gln Gly Ile Thr  Met Lys Asp 
    1235                 1240                 1245             


Ser Asp  Glu Glu Glu Glu Gly  
    1250                 1255 


<210>  1523
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CADPS__Homo_sapiens__NP_003707

<400>  1523

Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Ile Val Glu 
1               5                   10                  15      


Glu Glu Ser Gly Lys Glu Val Leu Gly Ser Ala Pro Ser Gly Ala Arg 
            20                  25                  30          


Leu Ser Pro Ser Arg Thr Ser Glu Gly Ser Ala Gly Ser Ala Gly Leu 
        35                  40                  45              


Gly Gly Gly Gly Ala Gly Ala Gly Ala Gly Val Gly Ala Gly Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Ala Ser Ser Gly Gly Gly Ala Gly Gly Leu Gln Pro 
65                  70                  75                  80  


Ser Ser Arg Ala Gly Gly Gly Arg Pro Ser Ser Pro Ser Pro Ser Val 
                85                  90                  95      


Val Ser Glu Lys Glu Lys Glu Glu Leu Glu Arg Leu Gln Lys Glu Glu 
            100                 105                 110         


Glu Glu Arg Lys Lys Arg Leu Gln Leu Tyr Val Phe Val Met Arg Cys 
        115                 120                 125             


Ile Ala Tyr Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg 
    130                 135                 140                 


Gln Gln Lys Ile Ser Lys Gln Gln Leu Gln Thr Val Lys Asp Arg Phe 
145                 150                 155                 160 


Gln Ala Phe Leu Asn Gly Glu Thr Gln Ile Met Ala Asp Glu Ala Phe 
                165                 170                 175     


Met Asn Ala Val Gln Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg 
            180                 185                 190         


Val Ala Arg Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Ser Arg 
        195                 200                 205             


Glu Val Phe Lys Lys His Ile Glu Lys Arg Val Arg Ser Leu Pro Glu 
    210                 215                 220                 


Ile Asp Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Met Ala Lys 
225                 230                 235                 240 


Phe Asp Ala Ile Tyr Arg Gly Glu Glu Asp Pro Arg Lys Gln Gln Ala 
                245                 250                 255     


Arg Met Thr Ala Ser Ala Ala Ser Glu Leu Ile Leu Ser Lys Glu Gln 
            260                 265                 270         


Leu Tyr Glu Met Phe Gln Asn Ile Leu Gly Ile Lys Lys Phe Glu His 
        275                 280                 285             


Gln Leu Leu Tyr Asn Ala Cys Gln Leu Asp Asn Pro Asp Glu Gln Ala 
    290                 295                 300                 


Ala Gln Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Met Ala Asp Gln 
305                 310                 315                 320 


Ile Ala Arg Glu Arg Lys Phe Pro Lys Phe Val Ser Lys Glu Met Glu 
                325                 330                 335     


Asn Met Tyr Ile Glu Glu Leu Lys Ser Ser Val Asn Leu Leu Met Ala 
            340                 345                 350         


Asn Leu Glu Ser Met Pro Val Ser Lys Gly Gly Glu Phe Lys Leu Gln 
        355                 360                 365             


Lys Leu Lys Arg Ser His Asn Ala Ser Ile Ile Asp Met Gly Glu Glu 
    370                 375                 380                 


Ser Glu Asn Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Ser Leu 
385                 390                 395                 400 


Glu Val Val Ile Met Glu Val Gln Gly Leu Lys Ser Leu Ala Pro Asn 
                405                 410                 415     


Arg Ile Val Tyr Cys Thr Met Glu Val Glu Gly Gly Glu Lys Leu Gln 
            420                 425                 430         


Thr Asp Gln Ala Glu Ala Ser Lys Pro Thr Trp Gly Thr Gln Gly Asp 
        435                 440                 445             


Phe Ser Thr Thr His Ala Leu Pro Ala Val Lys Val Lys Leu Phe Thr 
    450                 455                 460                 


Glu Ser Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val 
465                 470                 475                 480 


Ile Leu His Pro Thr Pro Asn Ser Pro Lys Gln Ser Glu Trp His Lys 
                485                 490                 495     


Met Thr Val Ser Lys Asn Cys Pro Asp Gln Asp Leu Lys Ile Lys Leu 
            500                 505                 510         


Ala Val Arg Met Asp Lys Pro Gln Asn Met Lys His Ser Gly Tyr Leu 
        515                 520                 525             


Trp Ala Ile Gly Lys Asn Val Trp Lys Arg Trp Lys Lys Arg Phe Phe 
    530                 535                 540                 


Val Leu Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg 
545                 550                 555                 560 


Glu Lys Lys Ala Glu Pro Gln Glu Leu Leu Gln Leu Asp Gly Tyr Thr 
                565                 570                 575     


Val Asp Tyr Thr Asp Pro Gln Pro Gly Leu Glu Gly Gly Arg Ala Phe 
            580                 585                 590         


Phe Asn Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp 
        595                 600                 605             


Glu Gln Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly 
    610                 615                 620                 


Gln Ser His Lys Pro Val Pro Pro Thr Gln Val Gln Lys Leu Asn Ala 
625                 630                 635                 640 


Lys Gly Gly Asn Val Pro Gln Leu Asp Ala Pro Ile Ser Gln Phe Tyr 
                645                 650                 655     


Ala Asp Arg Ala Gln Lys His Gly Met Asp Glu Phe Ile Ser Ser Asn 
            660                 665                 670         


Pro Cys Asn Phe Asp His Ala Ser Leu Phe Glu Met Val Gln Arg Leu 
        675                 680                 685             


Thr Leu Asp His Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe 
    690                 695                 700                 


Ser Pro Gly Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Asn Gly 
705                 710                 715                 720 


Val Arg Gly Cys His Arg His Leu Cys Tyr Leu Arg Asp Leu Leu Glu 
                725                 730                 735     


Arg Ala Glu Asn Gly Ala Met Ile Asp Pro Thr Leu Leu His Tyr Ser 
            740                 745                 750         


Phe Ala Phe Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile 
        755                 760                 765             


Gly Thr Val Thr Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu 
    770                 775                 780                 


Arg Leu Arg Val Leu Leu Glu Asn Gln Ile Thr His Phe Arg Tyr Cys 
785                 790                 795                 800 


Phe Pro Phe Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu 
                805                 810                 815     


Leu Glu Arg Val Leu Met Lys Asp Ile Val Thr Pro Val Pro Gln Glu 
            820                 825                 830         


Glu Val Lys Thr Val Ile Arg Lys Cys Leu Glu Gln Ala Ala Leu Val 
        835                 840                 845             


Asn Tyr Ser Arg Leu Ser Glu Tyr Ala Lys Ile Glu Glu Asn Gln Lys 
    850                 855                 860                 


Asp Ala Glu Asn Val Gly Arg Leu Ile Thr Pro Ala Lys Lys Leu Glu 
865                 870                 875                 880 


Asp Thr Ile Arg Leu Ala Glu Leu Val Ile Glu Val Leu Gln Gln Asn 
                885                 890                 895     


Glu Glu His His Ala Glu Pro His Val Asp Lys Gly Glu Ala Phe Ala 
            900                 905                 910         


Trp Trp Ser Asp Leu Met Val Glu His Ala Glu Thr Phe Leu Ser Leu 
        915                 920                 925             


Phe Ala Val Asp Met Asp Ala Ala Leu Glu Val Gln Pro Pro Asp Thr 
    930                 935                 940                 


Trp Asp Ser Phe Pro Leu Phe Gln Leu Leu Asn Asp Phe Leu Arg Thr 
945                 950                 955                 960 


Asp Tyr Asn Leu Cys Asn Gly Lys Phe His Lys His Leu Gln Asp Leu 
                965                 970                 975     


Phe Ala Pro Leu Val Val Arg Tyr Val Asp Leu Met Glu Ser Ser Ile 
            980                 985                 990         


Ala Gln Ser Ile His Arg Gly Phe  Glu Arg Glu Ser Trp  Glu Pro Val 
        995                 1000                 1005             


Lys Ser  Leu Thr Ser Asn Leu  Pro Asn Val Asn Leu  Pro Asn Val 
    1010                 1015                 1020             


Asn Leu  Pro Lys Val Pro Asn  Leu Pro Val Asn Ile  Pro Leu Gly 
    1025                 1030                 1035             


Ile Pro  Gln Met Pro Thr Phe  Ser Ala Pro Ser Trp  Met Ala Ala 
    1040                 1045                 1050             


Ile Tyr  Asp Ala Asp Asn Gly  Ser Gly Thr Ser Glu  Asp Leu Phe 
    1055                 1060                 1065             


Trp Lys  Leu Asp Ala Leu Gln  Thr Phe Ile Arg Asp  Leu His Trp 
    1070                 1075                 1080             


Pro Glu  Glu Glu Phe Gly Lys  His Leu Glu Gln Arg  Leu Lys Leu 
    1085                 1090                 1095             


Met Ala  Ser Asp Met Ile Glu  Ser Cys Val Lys Arg  Thr Arg Ile 
    1100                 1105                 1110             


Ala Phe  Glu Val Lys Leu Gln  Lys Thr Ser Arg Ser  Thr Asp Phe 
    1115                 1120                 1125             


Arg Val  Pro Gln Ser Ile Cys  Thr Met Phe Asn Val  Met Val Asp 
    1130                 1135                 1140             


Ala Lys  Ala Gln Ser Thr Lys  Leu Cys Ser Met Glu  Met Gly Gln 
    1145                 1150                 1155             


Glu His  Gln Tyr His Ser Lys  Ile Asp Glu Leu Ile  Glu Glu Thr 
    1160                 1165                 1170             


Val Lys  Glu Met Ile Thr Leu  Leu Val Ala Lys Phe  Val Thr Ile 
    1175                 1180                 1185             


Leu Glu  Gly Val Leu Ala Lys  Leu Ser Arg Tyr Asp  Glu Gly Thr 
    1190                 1195                 1200             


Leu Phe  Ser Ser Phe Leu Ser  Phe Thr Val Lys Ala  Ala Ser Lys 
    1205                 1210                 1215             


Tyr Val  Asp Val Pro Lys Pro  Gly Met Asp Val Ala  Asp Ala Tyr 
    1220                 1225                 1230             


Val Thr  Phe Val Arg His Ser  Gln Asp Val Leu Arg  Asp Lys Val 
    1235                 1240                 1245             


Asn Glu  Glu Met Tyr Ile Glu  Arg Leu Phe Asp Gln  Trp Tyr Asn 
    1250                 1255                 1260             


Ser Ser  Met Asn Val Ile Cys  Thr Trp Leu Thr Asp  Arg Met Asp 
    1265                 1270                 1275             


Leu Gln  Leu His Ile Tyr Gln  Leu Lys Thr Leu Ile  Arg Met Val 
    1280                 1285                 1290             


Lys Lys  Thr Tyr Arg Asp Phe  Arg Leu Gln Gly Val  Leu Asp Ser 
    1295                 1300                 1305             


Thr Leu  Asn Ser Lys Thr Tyr  Glu Thr Ile Arg Asn  Arg Leu Thr 
    1310                 1315                 1320             


Val Glu  Glu Ala Thr Ala Ser  Val Ser Glu Gly Gly  Gly Leu Gln 
    1325                 1330                 1335             


Gly Ile  Ser Met Lys Asp Ser  Asp Glu Glu Asp Glu  Glu Asp Asp 
    1340                 1345                 1350             


<210>  1524
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAGE1__Homo_sapiens__NP_001164163

<400>  1524

Met Asn Lys Asp Tyr Gln Lys Phe Trp Ser Ser Pro Ser Asp Pro Val 
1               5                   10                  15      


His Phe Glu Val Asp Thr Ser His Glu Lys Val Glu Ser Met Ser Glu 
            20                  25                  30          


Ser Asp Thr Met Asn Val Ser Asn Leu Ser Gln Gly Val Met Leu Ser 
        35                  40                  45              


His Ser Pro Ile Cys Met Glu Thr Thr Gly Thr Thr Cys Asp Leu Pro 
    50                  55                  60                  


Gln Asn Glu Ile Lys Asn Phe Glu Arg Glu Asn Glu Tyr Glu Ser Thr 
65                  70                  75                  80  


Leu Cys Glu Asp Ala Tyr Gly Thr Leu Asp Asn Leu Leu Asn Asp Asn 
                85                  90                  95      


Asn Ile Glu Asn Tyr Ser Thr Asn Ala Leu Ile Gln Pro Val Asp Thr 
            100                 105                 110         


Ile Ser Ile Ser Ser Leu Arg Gln Phe Glu Thr Val Cys Lys Phe His 
        115                 120                 125             


Trp Val Glu Ala Phe Asp Asp Glu Met Thr Glu Lys Pro Glu Phe Gln 
    130                 135                 140                 


Ser Gln Val Tyr Asn Tyr Ala Lys Asp Asn Asn Ile Lys Gln Asp Ser 
145                 150                 155                 160 


Phe Lys Glu Glu Asn Pro Met Glu Thr Ser Val Ser Ala Asn Thr Asp 
                165                 170                 175     


Gln Leu Gly Asn Glu Tyr Phe Arg Gln Pro Pro Pro Arg Ser Pro Pro 
            180                 185                 190         


Leu Ile His Cys Ser Gly Glu Met Leu Lys Phe Thr Glu Lys Ser Leu 
        195                 200                 205             


Ala Lys Ser Ile Ala Lys Glu Ser Ala Leu Asn Pro Ser Gln Pro Pro 
    210                 215                 220                 


Ser Phe Leu Cys Lys Thr Ala Val Pro Ser Lys Glu Ile Gln Asn Tyr 
225                 230                 235                 240 


Gly Glu Ile Pro Glu Met Ser Val Ser Tyr Glu Lys Glu Val Thr Ala 
                245                 250                 255     


Glu Gly Val Glu Arg Pro Glu Ile Val Ser Thr Trp Ser Ser Ala Gly 
            260                 265                 270         


Ile Ser Trp Arg Ser Glu Ala Cys Arg Glu Asn Cys Glu Met Pro Asp 
        275                 280                 285             


Trp Glu Gln Ser Ala Glu Ser Leu Gln Pro Val Gln Glu Asp Met Ala 
    290                 295                 300                 


Leu Asn Glu Val Leu Gln Lys Leu Lys His Thr Asn Arg Lys Gln Glu 
305                 310                 315                 320 


Val Arg Ile Gln Glu Leu Gln Cys Ser Asn Leu Tyr Leu Glu Lys Arg 
                325                 330                 335     


Val Lys Glu Leu Gln Met Lys Ile Thr Lys Gln Gln Val Phe Ile Asp 
            340                 345                 350         


Val Ile Asn Lys Leu Lys Glu Asn Val Glu Glu Leu Ile Glu Asp Lys 
        355                 360                 365             


Tyr Lys Ile Ile Leu Glu Lys Asn Asp Thr Lys Lys Thr Leu Gln Asn 
    370                 375                 380                 


Leu Glu Glu Val Leu Ala Asn Thr Gln Lys His Leu Gln Glu Ser Arg 
385                 390                 395                 400 


Asn Asp Lys Glu Met Leu Gln Leu Gln Phe Lys Lys Ile Lys Ala Asn 
                405                 410                 415     


Tyr Val Cys Leu Gln Glu Arg Tyr Met Thr Glu Met Gln Gln Lys Asn 
            420                 425                 430         


Lys Ser Val Ser Gln Tyr Leu Glu Met Asp Lys Thr Leu Ser Lys Lys 
        435                 440                 445             


Glu Glu Glu Val Glu Arg Leu Gln Gln Leu Lys Lys Glu Leu Glu Lys 
    450                 455                 460                 


Ala Thr Ala Ser Ala Leu Asp Leu Leu Lys Arg Glu Lys Glu Ala Gln 
465                 470                 475                 480 


Glu Gln Glu Phe Leu Ser Leu Gln Glu Glu Phe Gln Lys Leu Glu Lys 
                485                 490                 495     


Glu Asn Leu Glu Glu Arg Gln Lys Leu Lys Ser Arg Leu Glu Lys Leu 
            500                 505                 510         


Leu Thr Gln Val Arg Asn Leu Gln Phe Met Ser Glu Asn Glu Arg Thr 
        515                 520                 525             


Lys Asn Ile Lys Leu Gln Gln Gln Ile Asn Glu Val Lys Asn Glu Asn 
    530                 535                 540                 


Ala Lys Leu Lys Gln Gln Val Ala Arg Ser Glu Glu Gln Asn Tyr Val 
545                 550                 555                 560 


Pro Lys Phe Glu Thr Ala Gln Leu Lys Asp Gln Leu Glu Glu Val Leu 
                565                 570                 575     


Lys Ser Asp Ile Thr Lys Asp Thr Lys Thr Thr His Ser Asn Leu Leu 
            580                 585                 590         


Pro Asp Cys Ser Pro Cys Glu Glu Arg Leu Asn Pro Ala Asp Ile Lys 
        595                 600                 605             


Arg Ala Ser Gln Leu Ala Ser Lys Met His Ser Leu Leu Ala Leu Met 
    610                 615                 620                 


Val Gly Leu Leu Thr Cys Gln Asp Ile Ile Asn Ser Asp Ala Glu His 
625                 630                 635                 640 


Phe Lys Glu Ser Glu Lys Val Ser Asp Ile Met Leu Gln Lys Leu Lys 
                645                 650                 655     


Ser Leu His Leu Lys Lys Lys Thr Leu Asp Lys Glu Leu Leu Lys His 
            660                 665                 670         


Lys Asp Arg Ile Thr Thr Phe Arg Glu Leu Ile Ala Lys Glu Lys Ala 
        675                 680                 685             


Phe Gln Asp His Ala Ile Lys Val Ile Asp Cys Asp Ser Asp Glu Ala 
    690                 695                 700                 


Lys Ser Ile Arg Asp Val Pro Thr Leu Leu Gly Ala Lys Leu Asp Lys 
705                 710                 715                 720 


Tyr His Ser Leu Asn Glu Glu Leu Asp Phe Leu Ile Thr Lys Leu Gly 
                725                 730                 735     


His Leu Leu Glu Ser Lys Glu Asn His Cys Asn Arg Leu Ile Glu Glu 
            740                 745                 750         


Asn Asp Lys Tyr Gln Arg His Leu Gly Asn Leu Ile Lys Lys Val Thr 
        755                 760                 765             


Ser Tyr Glu Glu Ile Ile Glu Cys Ala Asp Gln Arg Leu Ala Ile Ser 
    770                 775                 780                 


His Ser Gln Ile Ala His Leu Glu Glu Arg Asn Lys His Leu Glu Asp 
785                 790                 795                 800 


Leu Ile Arg Lys Pro Arg Glu Lys Ala Arg Lys Pro Arg Ser Lys Ser 
                805                 810                 815     


Leu Glu Asn His Pro Lys Ser Met Thr Met Met Pro Ala Leu Phe Lys 
            820                 825                 830         


Glu Asn Arg Asn Asp Leu Asp 
        835                 


<210>  1525
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALB1__Homo_sapiens__NP_004920

<400>  1525

Met Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe 
1               5                   10                  15      


Phe Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu 
            20                  25                  30          


Gly Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Gln Gln Ala Arg Lys 
        35                  40                  45              


Lys Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln 
    50                  55                  60                  


Tyr Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His 
65                  70                  75                  80  


Val Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln 
                85                  90                  95      


Leu Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr 
            100                 105                 110         


Asp His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys 
        115                 120                 125             


Asp Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala 
    130                 135                 140                 


Glu Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly 
145                 150                 155                 160 


Lys Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn 
                165                 170                 175     


Phe Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn 
            180                 185                 190         


Lys Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu 
        195                 200                 205             


Asn Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln 
    210                 215                 220                 


Asp Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala 
225                 230                 235                 240 


Leu Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu 
                245                 250                 255     


Cys Ala Gly Asp Asn 
            260     


<210>  1526
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALB2__Homo_sapiens__NP_001731

<400>  1526

Met Ala Gly Pro Gln Gln Gln Pro Pro Tyr Leu His Leu Ala Glu Leu 
1               5                   10                  15      


Thr Ala Ser Gln Phe Leu Glu Ile Trp Lys His Phe Asp Ala Asp Gly 
            20                  25                  30          


Asn Gly Tyr Ile Glu Gly Lys Glu Leu Glu Asn Phe Phe Gln Glu Leu 
        35                  40                  45              


Glu Lys Ala Arg Lys Gly Ser Gly Met Met Ser Lys Ser Asp Asn Phe 
    50                  55                  60                  


Gly Glu Lys Met Lys Glu Phe Met Gln Lys Tyr Asp Lys Asn Ser Asp 
65                  70                  75                  80  


Gly Lys Ile Glu Met Ala Glu Leu Ala Gln Ile Leu Pro Thr Glu Glu 
                85                  90                  95      


Asn Phe Leu Leu Cys Phe Arg Gln His Val Gly Ser Ser Ala Glu Phe 
            100                 105                 110         


Met Glu Ala Trp Arg Lys Tyr Asp Thr Asp Arg Ser Gly Tyr Ile Glu 
        115                 120                 125             


Ala Asn Glu Leu Lys Gly Phe Leu Ser Asp Leu Leu Lys Lys Ala Asn 
    130                 135                 140                 


Arg Pro Tyr Asp Glu Pro Lys Leu Gln Glu Tyr Thr Gln Thr Ile Leu 
145                 150                 155                 160 


Arg Met Phe Asp Leu Asn Gly Asp Gly Lys Leu Gly Leu Ser Glu Met 
                165                 170                 175     


Ser Arg Leu Leu Pro Val Gln Glu Asn Phe Leu Leu Lys Phe Gln Gly 
            180                 185                 190         


Met Lys Leu Thr Ser Glu Glu Phe Asn Ala Ile Phe Thr Phe Tyr Asp 
        195                 200                 205             


Lys Asp Arg Ser Gly Tyr Ile Asp Glu His Glu Leu Asp Ala Leu Leu 
    210                 215                 220                 


Lys Asp Leu Tyr Glu Lys Asn Lys Lys Glu Met Asn Ile Gln Gln Leu 
225                 230                 235                 240 


Thr Asn Tyr Arg Lys Ser Val Met Ser Leu Ala Glu Ala Gly Lys Leu 
                245                 250                 255     


Tyr Arg Lys Asp Leu Glu Ile Val Leu Cys Ser Glu Pro Pro Met 
            260                 265                 270     


<210>  1527
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALCA__Homo_sapiens__NP_001029125

<400>  1527

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Arg Ile Ile Ala Gln 
65                  70                  75                  80  


Lys Arg Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly 
                85                  90                  95      


Leu Leu Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr 
            100                 105                 110         


Asn Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125             


<210>  1528
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALCB__Homo_sapiens__NP_000719

<400>  1528

Met Gly Phe Arg Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Tyr Gln Ala Gly Ser Leu Gln Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Asp Pro Ala Thr Leu Ser Lys Glu Asp Ala Arg Leu 
        35                  40                  45              


Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser Glu 
    50                  55                  60                  


Leu Lys Gln Glu Gln Glu Thr Gln Gly Ser Ser Ser Ala Ala Gln Lys 
65                  70                  75                  80  


Arg Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu 
                85                  90                  95      


Leu Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn 
            100                 105                 110         


Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125         


<210>  1529
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALCOCO1__Homo_sapiens__NP_001137154

<400>  1529

Met Glu Glu Ser Pro Leu Ser Arg Ala Pro Ser Arg Gly Gly Val Asn 
1               5                   10                  15      


Phe Leu Asn Val Ala Arg Thr Tyr Ile Pro Asn Thr Lys Val Glu Cys 
            20                  25                  30          


His Tyr Thr Leu Pro Pro Gly Thr Met Pro Ser Ala Ser Asp Trp Ile 
        35                  40                  45              


Gly Ile Phe Lys Val Glu Ala Ala Cys Val Arg Asp Tyr His Thr Phe 
    50                  55                  60                  


Val Trp Ser Ser Val Pro Glu Ser Thr Thr Asp Gly Ser Pro Ile His 
65                  70                  75                  80  


Thr Ser Val Gln Phe Gln Glu Pro Arg Pro Met Asp Glu Leu Val Thr 
                85                  90                  95      


Leu Glu Glu Ala Asp Gly Gly Ser Asp Ile Leu Leu Val Val Pro Lys 
            100                 105                 110         


Ala Thr Val Leu Gln Asn Gln Leu Asp Glu Ser Gln Gln Glu Arg Asn 
        115                 120                 125             


Asp Leu Met Gln Leu Lys Leu Gln Leu Glu Gly Gln Val Thr Glu Leu 
    130                 135                 140                 


Arg Ser Arg Val Gln Glu Leu Glu Arg Ala Leu Ala Thr Ala Arg Gln 
145                 150                 155                 160 


Glu His Thr Glu Leu Met Glu Gln Tyr Lys Gly Ile Ser Arg Ser His 
                165                 170                 175     


Gly Glu Ile Thr Glu Glu Arg Asp Ile Leu Ser Arg Gln Gln Gly Asp 
            180                 185                 190         


His Val Ala Arg Ile Leu Glu Leu Glu Asp Asp Ile Gln Thr Ile Ser 
        195                 200                 205             


Glu Lys Val Leu Thr Lys Glu Val Glu Leu Asp Arg Leu Arg Asp Thr 
    210                 215                 220                 


Val Lys Ala Leu Thr Arg Glu Gln Glu Lys Leu Leu Gly Gln Leu Lys 
225                 230                 235                 240 


Glu Val Gln Ala Asp Lys Glu Gln Ser Glu Ala Glu Leu Glu Pro Leu 
                245                 250                 255     


Lys Glu Gln Leu Arg Gly Ala Gln Glu Leu Ala Ala Ser Ser Gln Gln 
            260                 265                 270         


Lys Ala Thr Leu Leu Gly Glu Glu Leu Ala Ser Ala Ala Ala Ala Arg 
        275                 280                 285             


Asp Arg Thr Ile Ala Glu Leu His Arg Ser Arg Leu Glu Val Ala Glu 
    290                 295                 300                 


Val Asn Gly Arg Leu Ala Glu Leu Gly Leu His Leu Lys Glu Glu Lys 
305                 310                 315                 320 


Cys Gln Trp Ser Lys Glu Arg Ala Gly Leu Leu Gln Ser Val Glu Ala 
                325                 330                 335     


Glu Lys Asp Lys Ile Leu Lys Leu Ser Ala Glu Ile Leu Arg Leu Glu 
            340                 345                 350         


Lys Ala Val Gln Glu Glu Arg Thr Gln Asn Gln Val Phe Lys Thr Glu 
        355                 360                 365             


Leu Ala Arg Glu Lys Asp Ser Ser Leu Val Gln Leu Ser Glu Ser Lys 
    370                 375                 380                 


Arg Glu Leu Thr Glu Leu Arg Ser Ala Leu Arg Val Leu Gln Lys Glu 
385                 390                 395                 400 


Lys Glu Gln Leu Gln Glu Glu Lys Gln Glu Leu Leu Glu Tyr Met Arg 
                405                 410                 415     


Lys Leu Glu Ala Arg Leu Glu Lys Val Ala Asp Glu Lys Trp Asn Glu 
            420                 425                 430         


Asp Ala Thr Thr Glu Asp Glu Glu Ala Ala Val Gly Leu Ser Cys Pro 
        435                 440                 445             


Ala Ala Leu Thr Asp Ser Glu Asp Glu Ser Pro Glu Asp Met Arg Leu 
    450                 455                 460                 


Pro Pro Tyr Gly Leu Cys Glu Arg Gly Asp Pro Gly Ser Ser Pro Ala 
465                 470                 475                 480 


Gly Pro Arg Glu Ala Ser Pro Leu Val Val Ile Ser Gln Pro Ala Pro 
                485                 490                 495     


Ile Ser Pro His Leu Ser Gly Pro Ala Glu Asp Ser Ser Ser Asp Ser 
            500                 505                 510         


Glu Ala Glu Asp Glu Lys Ser Val Leu Met Ala Ala Val Gln Ser Gly 
        515                 520                 525             


Gly Glu Glu Ala Asn Leu Leu Leu Pro Glu Leu Gly Ser Ala Phe Tyr 
    530                 535                 540                 


Asp Met Ala Ser Gly Phe Thr Val Gly Thr Leu Ser Glu Thr Ser Thr 
545                 550                 555                 560 


Gly Gly Pro Ala Thr Pro Thr Trp Lys Glu Cys Pro Ile Cys Lys Glu 
                565                 570                 575     


Arg Phe Pro Ala Glu Ser Asp Lys Asp Ala Leu Glu Asp His Met Asp 
            580                 585                 590         


Gly His Phe Phe Phe Ser Thr Gln Asp Pro Phe Thr Phe Glu 
        595                 600                 605     


<210>  1530
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALCOCO2__Homo_sapiens__NP_001248319

<400>  1530

Met Glu Glu Thr Ile Lys Asp Pro Pro Thr Ser Ala Val Leu Leu Asp 
1               5                   10                  15      


His Cys His Phe Ser Gln Val Ile Phe Asn Ser Val Glu Lys Phe Tyr 
            20                  25                  30          


Ile Pro Gly Gly Asp Val Thr Cys His Tyr Thr Phe Thr Gln His Phe 
        35                  40                  45              


Ile Pro Arg Arg Lys Asp Trp Ile Gly Ile Phe Arg Ala Phe Lys Cys 
    50                  55                  60                  


Phe Gln Asp Lys Leu Glu Gln Glu Leu Leu Lys Trp Arg Ser Gln Gly 
65                  70                  75                  80  


Gln Lys Leu Gln Val Gly Trp Lys Thr Thr Arg Glu Tyr Tyr Thr Phe 
                85                  90                  95      


Met Trp Val Thr Leu Pro Ile Asp Leu Asn Asn Lys Ser Ala Lys Gln 
            100                 105                 110         


Gln Glu Val Gln Phe Lys Ala Tyr Tyr Leu Pro Lys Asp Asp Glu Tyr 
        115                 120                 125             


Tyr Gln Phe Cys Tyr Val Asp Glu Asp Gly Val Val Arg Gly Ala Ser 
    130                 135                 140                 


Ile Pro Phe Gln Phe Arg Pro Glu Asn Glu Glu Asp Ile Leu Val Val 
145                 150                 155                 160 


Thr Thr Gln Gly Glu Val Glu Glu Ile Glu Gln His Asn Lys Glu Leu 
                165                 170                 175     


Cys Lys Glu Asn Gln Glu Leu Lys Asp Ser Cys Ile Ser Leu Gln Lys 
            180                 185                 190         


Gln Asn Ser Asp Met Gln Ala Glu Leu Gln Lys Lys Gln Glu Glu Leu 
        195                 200                 205             


Glu Thr Leu Gln Ser Ile Asn Lys Lys Leu Glu Leu Lys Val Lys Glu 
    210                 215                 220                 


Gln Lys Asp Tyr Trp Glu Thr Glu Leu Leu Gln Leu Lys Glu Gln Asn 
225                 230                 235                 240 


Gln Lys Met Ser Ser Glu Asn Glu Lys Met Gly Ile Arg Val Asp Gln 
                245                 250                 255     


Leu Gln Ala Gln Leu Ser Thr Gln Glu Lys Glu Met Glu Lys Leu Val 
            260                 265                 270         


Gln Gly Asp Gln Asp Lys Thr Glu Gln Leu Glu Gln Leu Lys Lys Glu 
        275                 280                 285             


Asn Asp His Leu Phe Leu Ser Leu Thr Glu Gln Arg Lys Asp Gln Lys 
    290                 295                 300                 


Lys Leu Glu Gln Thr Val Glu Gln Met Lys Gln Asn Glu Thr Thr Ala 
305                 310                 315                 320 


Met Lys Lys Gln Gln Glu Leu Met Asp Glu Asn Phe Asp Leu Ser Lys 
                325                 330                 335     


Arg Leu Ser Glu Asn Glu Ile Ile Cys Asn Ala Leu Gln Arg Gln Lys 
            340                 345                 350         


Glu Arg Leu Glu Gly Glu Asn Asp Leu Leu Lys Arg Glu Asn Ser Arg 
        355                 360                 365             


Leu Leu Ser Tyr Met Gly Leu Asp Phe Asn Ser Leu Pro Tyr Gln Val 
    370                 375                 380                 


Pro Thr Ser Asp Glu Gly Gly Ala Arg Gln Asn Pro Gly Leu Ala Tyr 
385                 390                 395                 400 


Gly Asn Pro Tyr Ser Gly Ile Gln Glu Ser Ser Ser Pro Ser Pro Leu 
                405                 410                 415     


Ser Ile Lys Lys Cys Pro Ile Cys Lys Ala Asp Asp Ile Cys Asp His 
            420                 425                 430         


Thr Leu Glu Gln Gln Gln Met Gln Pro Leu Cys Phe Asn Cys Pro Ile 
        435                 440                 445             


Cys Asp Lys Ile Phe Pro Ala Thr Glu Lys Gln Ile Phe Glu Asp His 
    450                 455                 460                 


Val Phe Cys His Ser Leu 
465                 470 


<210>  1531
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALCR__Homo_sapiens__NP_001158209

<400>  1531

Met Gln Phe Ser Gly Glu Lys Ile Ser Gly Gln Arg Asp Leu Gln Lys 
1               5                   10                  15      


Ser Lys Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu 
            20                  25                  30          


Leu Leu Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr 
        35                  40                  45              


Tyr Pro Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys 
    50                  55                  60                  


Lys Met Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu 
65                  70                  75                  80  


Pro Ala Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly 
                85                  90                  95      


Trp Leu Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe 
            100                 105                 110         


Cys Pro Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys 
        115                 120                 125             


Tyr Cys Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg 
    130                 135                 140                 


Thr Trp Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu 
145                 150                 155                 160 


Lys Asn Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu 
                165                 170                 175     


Ser Ile Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg 
            180                 185                 190         


Lys Leu Thr Thr Ile Phe Pro Leu Asn Trp Lys Tyr Arg Lys Ala Leu 
        195                 200                 205             


Ser Leu Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr 
    210                 215                 220                 


Tyr Ile Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val 
225                 230                 235                 240 


Pro Asn Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu 
                245                 250                 255     


His Phe Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu 
            260                 265                 270         


Cys Glu Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr 
        275                 280                 285             


Glu Lys Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro 
    290                 295                 300                 


Leu Val Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn 
305                 310                 315                 320 


Asp Asn Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His 
                325                 330                 335     


Gly Pro Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn 
            340                 345                 350         


Ile Val Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu 
        355                 360                 365             


Ser His Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro 
    370                 375                 380                 


Leu Leu Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys 
385                 390                 395                 400 


Met Leu Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe 
                405                 410                 415     


Gln Gly Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val 
            420                 425                 430         


Gln Thr Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn 
        435                 440                 445             


Gln Arg Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu 
465                 470                 475                 480 


Leu Arg Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile 
                485                 490                 495     


Ile Pro Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
            500                 505             


<210>  1532
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALCRL__Homo_sapiens__NP_005786

<400>  1532

Met Glu Lys Lys Cys Thr Leu Tyr Phe Leu Val Leu Leu Pro Phe Phe 
1               5                   10                  15      


Met Ile Leu Val Thr Ala Glu Leu Glu Glu Ser Pro Glu Asp Ser Ile 
            20                  25                  30          


Gln Leu Gly Val Thr Arg Asn Lys Ile Met Thr Ala Gln Tyr Glu Cys 
        35                  40                  45              


Tyr Gln Lys Ile Met Gln Asp Pro Ile Gln Gln Ala Glu Gly Val Tyr 
    50                  55                  60                  


Cys Asn Arg Thr Trp Asp Gly Trp Leu Cys Trp Asn Asp Val Ala Ala 
65                  70                  75                  80  


Gly Thr Glu Ser Met Gln Leu Cys Pro Asp Tyr Phe Gln Asp Phe Asp 
                85                  90                  95      


Pro Ser Glu Lys Val Thr Lys Ile Cys Asp Gln Asp Gly Asn Trp Phe 
            100                 105                 110         


Arg His Pro Ala Ser Asn Arg Thr Trp Thr Asn Tyr Thr Gln Cys Asn 
        115                 120                 125             


Val Asn Thr His Glu Lys Val Lys Thr Ala Leu Asn Leu Phe Tyr Leu 
    130                 135                 140                 


Thr Ile Ile Gly His Gly Leu Ser Ile Ala Ser Leu Leu Ile Ser Leu 
145                 150                 155                 160 


Gly Ile Phe Phe Tyr Phe Lys Ser Leu Ser Cys Gln Arg Ile Thr Leu 
                165                 170                 175     


His Lys Asn Leu Phe Phe Ser Phe Val Cys Asn Ser Val Val Thr Ile 
            180                 185                 190         


Ile His Leu Thr Ala Val Ala Asn Asn Gln Ala Leu Val Ala Thr Asn 
        195                 200                 205             


Pro Val Ser Cys Lys Val Ser Gln Phe Ile His Leu Tyr Leu Met Gly 
    210                 215                 220                 


Cys Asn Tyr Phe Trp Met Leu Cys Glu Gly Ile Tyr Leu His Thr Leu 
225                 230                 235                 240 


Ile Val Val Ala Val Phe Ala Glu Lys Gln His Leu Met Trp Tyr Tyr 
                245                 250                 255     


Phe Leu Gly Trp Gly Phe Pro Leu Ile Pro Ala Cys Ile His Ala Ile 
            260                 265                 270         


Ala Arg Ser Leu Tyr Tyr Asn Asp Asn Cys Trp Ile Ser Ser Asp Thr 
        275                 280                 285             


His Leu Leu Tyr Ile Ile His Gly Pro Ile Cys Ala Ala Leu Leu Val 
    290                 295                 300                 


Asn Leu Phe Phe Leu Leu Asn Ile Val Arg Val Leu Ile Thr Lys Leu 
305                 310                 315                 320 


Lys Val Thr His Gln Ala Glu Ser Asn Leu Tyr Met Lys Ala Val Arg 
                325                 330                 335     


Ala Thr Leu Ile Leu Val Pro Leu Leu Gly Ile Glu Phe Val Leu Ile 
            340                 345                 350         


Pro Trp Arg Pro Glu Gly Lys Ile Ala Glu Glu Val Tyr Asp Tyr Ile 
        355                 360                 365             


Met His Ile Leu Met His Phe Gln Gly Leu Leu Val Ser Thr Ile Phe 
    370                 375                 380                 


Cys Phe Phe Asn Gly Glu Val Gln Ala Ile Leu Arg Arg Asn Trp Asn 
385                 390                 395                 400 


Gln Tyr Lys Ile Gln Phe Gly Asn Ser Phe Ser Asn Ser Glu Ala Leu 
                405                 410                 415     


Arg Ser Ala Ser Tyr Thr Val Ser Thr Ile Ser Asp Gly Pro Gly Tyr 
            420                 425                 430         


Ser His Asp Cys Pro Ser Glu His Leu Asn Gly Lys Ser Ile His Asp 
        435                 440                 445             


Ile Glu Asn Val Leu Leu Lys Pro Glu Asn Leu Tyr Asn 
    450                 455                 460     


<210>  1533
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALD1__Homo_sapiens__NP_004333

<400>  1533

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Ile 
        195                 200                 205             


Lys Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys 
    210                 215                 220                 


Ser Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn 
225                 230                 235                 240 


Gly Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser 
                245                 250                 255     


Arg Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala 
            260                 265                 270         


Pro Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg 
        275                 280                 285             


Gly Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln 
    290                 295                 300                 


Glu Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg 
305                 310                 315                 320 


Arg Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala 
                325                 330                 335     


Asp Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu 
            340                 345                 350         


Ile Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro 
        355                 360                 365             


Glu Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro 
    370                 375                 380                 


Lys Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys 
385                 390                 395                 400 


Ser Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile 
                405                 410                 415     


Val Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu 
            420                 425                 430         


Gly Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro 
        435                 440                 445             


Val Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly 
    450                 455                 460                 


Asn Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr 
465                 470                 475                 480 


Ala Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr 
                485                 490                 495     


Lys Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu 
            500                 505                 510         


Arg Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser 
        515                 520                 525             


Val Asp Lys Val Thr Ser Pro Thr Lys Val 
    530                 535             


<210>  1534
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALHM1__Homo_sapiens__NP_001001412

<400>  1534

Met Met Asp Lys Phe Arg Met Ile Phe Gln Phe Leu Gln Ser Asn Gln 
1               5                   10                  15      


Glu Ser Phe Met Asn Gly Ile Cys Gly Ile Met Ala Leu Ala Ser Ala 
            20                  25                  30          


Gln Met Tyr Ser Ala Phe Asp Phe Asn Cys Pro Cys Leu Pro Gly Tyr 
        35                  40                  45              


Asn Ala Ala Tyr Ser Ala Gly Ile Leu Leu Ala Pro Pro Leu Val Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Val Met Asn Asn Asn Val Ser Met Leu Ala Glu 
65                  70                  75                  80  


Glu Trp Lys Arg Pro Leu Gly Arg Arg Ala Lys Asp Pro Ala Val Leu 
                85                  90                  95      


Arg Tyr Met Phe Cys Ser Met Ala Gln Arg Ala Leu Ile Ala Pro Val 
            100                 105                 110         


Val Trp Val Ala Val Thr Leu Leu Asp Gly Lys Cys Phe Leu Cys Ala 
        115                 120                 125             


Phe Cys Thr Ala Val Pro Val Ser Ala Leu Gly Asn Gly Ser Leu Ala 
    130                 135                 140                 


Pro Gly Leu Pro Ala Pro Glu Leu Ala Arg Leu Leu Ala Arg Val Pro 
145                 150                 155                 160 


Cys Pro Glu Ile Tyr Asp Gly Asp Trp Leu Leu Ala Arg Glu Val Ala 
                165                 170                 175     


Val Arg Tyr Leu Arg Cys Ile Ser Gln Ala Leu Gly Trp Ser Phe Val 
            180                 185                 190         


Leu Leu Thr Thr Leu Leu Ala Phe Val Val Arg Ser Val Arg Pro Cys 
        195                 200                 205             


Phe Thr Gln Ala Ala Phe Leu Lys Ser Lys Tyr Trp Ser His Tyr Ile 
    210                 215                 220                 


Asp Ile Glu Arg Lys Leu Phe Asp Glu Thr Cys Thr Glu His Ala Lys 
225                 230                 235                 240 


Ala Phe Ala Lys Val Cys Ile Gln Gln Phe Phe Glu Ala Met Asn His 
                245                 250                 255     


Asp Leu Glu Leu Gly His Thr His Gly Thr Leu Ala Thr Ala Pro Ala 
            260                 265                 270         


Ser Ala Ala Ala Pro Thr Thr Pro Asp Gly Ala Glu Glu Glu Arg Glu 
        275                 280                 285             


Lys Leu Arg Gly Ile Thr Asp Gln Gly Thr Met Asn Arg Leu Leu Thr 
    290                 295                 300                 


Ser Trp His Lys Cys Lys Pro Pro Leu Arg Leu Gly Gln Glu Glu Pro 
305                 310                 315                 320 


Pro Leu Met Gly Asn Gly Trp Ala Gly Gly Gly Pro Arg Pro Pro Arg 
                325                 330                 335     


Lys Glu Val Ala Thr Tyr Phe Ser Lys Val 
            340                 345     


<210>  1535
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALHM2__Homo_sapiens__XP_006717946

<400>  1535

Met Ala Ala Leu Ile Ala Glu Asn Phe Arg Phe Leu Ser Leu Phe Phe 
1               5                   10                  15      


Lys Ser Lys Asp Val Met Ile Phe Asn Gly Leu Val Ala Leu Gly Thr 
            20                  25                  30          


Val Gly Ser Gln Glu Leu Phe Ser Val Val Ala Phe His Cys Pro Cys 
        35                  40                  45              


Ser Pro Ala Arg Asn Tyr Leu Tyr Gly Leu Ala Ala Ile Gly Val Pro 
    50                  55                  60                  


Ala Leu Val Leu Phe Ile Ile Gly Ile Ile Leu Asn Asn His Thr Trp 
65                  70                  75                  80  


Asn Leu Val Ala Glu Cys Gln His Arg Arg Thr Lys Asn Cys Ser Ala 
                85                  90                  95      


Ala Pro Thr Phe Leu Leu Leu Ser Ser Ile Leu Gly Arg Ala Ala Val 
            100                 105                 110         


Ala Pro Val Thr Trp Ser Val Ile Ser Leu Leu Arg Gly Glu Ala Tyr 
        115                 120                 125             


Val Cys Ala Leu Ser Glu Phe Val Asp Pro Ser Ser Leu Thr Ala Arg 
    130                 135                 140                 


Glu Glu His Phe Pro Ser Ala His Ala Thr Glu Ile Leu Ala Arg Phe 
145                 150                 155                 160 


Pro Cys Lys Glu Asn Pro Asp Asn Leu Ser Asp Phe Arg Glu Glu Val 
                165                 170                 175     


Ser Arg Arg Leu Arg Tyr Glu Ser Gln Leu Phe Gly Trp Leu Leu Ile 
            180                 185                 190         


Gly Val Val Ala Ile Leu Val Phe Leu Thr Lys Cys Leu Lys His Tyr 
        195                 200                 205             


Cys Ser Pro Leu Ser Tyr Arg Gln Glu Ala Tyr Trp Ala Gln Tyr Arg 
    210                 215                 220                 


Ala Asn Glu Asp Gln Leu Phe Gln Arg Thr Ala Glu Val His Ser Arg 
225                 230                 235                 240 


Val Leu Ala Ala Asn Asn Val Arg Arg Phe Phe Gly Phe Val Ala Leu 
                245                 250                 255     


Asn Lys Asp Asp Glu Glu Leu Ile Ala Asn Phe Pro Val Glu Gly Thr 
            260                 265                 270         


Gln Pro Arg Pro Gln Trp Asn Ala Ile Thr Gly Val Tyr Leu Tyr Arg 
        275                 280                 285             


Glu Asn Gln Gly Leu Pro Leu Tyr Ser Arg Leu His Lys Trp Ala Gln 
    290                 295                 300                 


Gly Leu Ala Gly Asn Gly Ala Ala Pro Asp Asn Val Glu Met Ala Leu 
305                 310                 315                 320 


Leu Pro Ser 
            


<210>  1536
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALHM3__Homo_sapiens__NP_001123214

<400>  1536

Met Asp Lys Phe Arg Met Leu Phe Gln His Phe Gln Ser Ser Ser Glu 
1               5                   10                  15      


Ser Val Met Asn Gly Ile Cys Leu Leu Leu Ala Ala Val Thr Val Lys 
            20                  25                  30          


Leu Tyr Ser Ser Phe Asp Phe Asn Cys Pro Cys Leu Val His Tyr Asn 
        35                  40                  45              


Ala Leu Tyr Gly Leu Gly Leu Leu Leu Thr Pro Pro Leu Ala Leu Phe 
    50                  55                  60                  


Leu Cys Gly Leu Leu Ala Asn Arg Gln Ser Val Val Met Val Glu Glu 
65                  70                  75                  80  


Trp Arg Arg Pro Ala Gly His Arg Arg Lys Asp Pro Gly Ile Ile Arg 
                85                  90                  95      


Tyr Met Cys Ser Ser Val Leu Gln Arg Ala Leu Ala Ala Pro Leu Val 
            100                 105                 110         


Trp Ile Leu Leu Ala Leu Leu Asp Gly Lys Cys Phe Val Cys Ala Phe 
        115                 120                 125             


Ser Ser Ser Val Asp Pro Glu Lys Phe Leu Asp Phe Ala Asn Met Thr 
    130                 135                 140                 


Pro Ser Gln Val Gln Leu Phe Leu Ala Lys Val Pro Cys Lys Glu Asp 
145                 150                 155                 160 


Glu Leu Val Arg Asp Ser Pro Ala Arg Lys Ala Val Ser Arg Tyr Leu 
                165                 170                 175     


Arg Cys Leu Ser Gln Ala Ile Gly Trp Ser Val Thr Leu Leu Leu Ile 
            180                 185                 190         


Ile Ala Ala Phe Leu Ala Arg Cys Leu Arg Pro Cys Phe Asp Gln Thr 
        195                 200                 205             


Val Phe Leu Gln Arg Arg Tyr Trp Ser Asn Tyr Val Asp Leu Glu Gln 
    210                 215                 220                 


Lys Leu Phe Asp Glu Thr Cys Cys Glu His Ala Arg Asp Phe Ala His 
225                 230                 235                 240 


Arg Cys Val Leu His Phe Phe Ala Ser Met Arg Ser Glu Leu Gln Ala 
                245                 250                 255     


Arg Gly Leu Arg Arg Gly Asn Ala Gly Arg Arg Leu Glu Leu Pro Ala 
            260                 265                 270         


Val Pro Glu Pro Pro Glu Gly Leu Asp Ser Gly Ser Gly Lys Ala His 
        275                 280                 285             


Leu Arg Ala Ile Ser Ser Arg Glu Gln Val Asp Arg Leu Leu Ser Thr 
    290                 295                 300                 


Trp Tyr Ser Ser Lys Pro Pro Leu Asp Leu Ala Ala Ser Pro Gly Leu 
305                 310                 315                 320 


Cys Gly Gly Gly Leu Ser His Arg Ala Pro Thr Leu Ala Leu Gly Thr 
                325                 330                 335     


Arg Leu Ser Gln His Thr Asp Val 
            340                 


<210>  1537
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALM2__Homo_sapiens__NP_001734

<400>  1537

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys 
145                 


<210>  1538
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALML3__Homo_sapiens__NP_005176

<400>  1538

Met Ala Asp Gln Leu Thr Glu Glu Gln Val Thr Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Arg Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Arg Asp Met Met Ser Glu Ile Asp Arg Asp Gly Asn Gly Thr Val 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Gly Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Asn Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Phe Val Ser Ala Ala Glu Leu Arg His Val Met Thr Arg 
            100                 105                 110         


Leu Gly Glu Lys Leu Ser Asp Glu Glu Val Asp Glu Met Ile Arg Ala 
        115                 120                 125             


Ala Asp Thr Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Arg 
    130                 135                 140                 


Val Leu Val Ser Lys 
145                 


<210>  1539
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALML5__Homo_sapiens__NP_059118

<400>  1539

Met Ala Gly Glu Leu Thr Pro Glu Glu Glu Ala Gln Tyr Lys Lys Ala 
1               5                   10                  15      


Phe Ser Ala Val Asp Thr Asp Gly Asn Gly Thr Ile Asn Ala Gln Glu 
            20                  25                  30          


Leu Gly Ala Ala Leu Lys Ala Thr Gly Lys Asn Leu Ser Glu Ala Gln 
        35                  40                  45              


Leu Arg Lys Leu Ile Ser Glu Val Asp Ser Asp Gly Asp Gly Glu Ile 
    50                  55                  60                  


Ser Phe Gln Glu Phe Leu Thr Ala Ala Lys Lys Ala Arg Ala Gly Leu 
65                  70                  75                  80  


Glu Asp Leu Gln Val Ala Phe Arg Ala Phe Asp Gln Asp Gly Asp Gly 
                85                  90                  95      


His Ile Thr Val Asp Glu Leu Arg Arg Ala Met Ala Gly Leu Gly Gln 
            100                 105                 110         


Pro Leu Pro Gln Glu Glu Leu Asp Ala Met Ile Arg Glu Ala Asp Val 
        115                 120                 125             


Asp Gln Asp Gly Arg Val Asn Tyr Glu Glu Phe Ala Arg Met Leu Ala 
    130                 135                 140                 


Gln Glu 
145     


<210>  1540
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALN1__Homo_sapiens__NP_001017440

<400>  1540

Met Pro Phe His His Val Thr Ala Gly Leu Leu Tyr Lys Gly Asn Tyr 
1               5                   10                  15      


Leu Asn Arg Ser Leu Ser Ala Gly Ser Asp Ser Glu Gln Leu Ala Asn 
            20                  25                  30          


Ile Ser Val Glu Glu Leu Asp Glu Ile Arg Glu Ala Phe Arg Val Leu 
        35                  40                  45              


Asp Arg Asp Gly Asn Gly Phe Ile Ser Lys Gln Glu Leu Gly Met Ala 
    50                  55                  60                  


Met Arg Ser Leu Gly Tyr Met Pro Ser Glu Val Glu Leu Ala Ile Ile 
65                  70                  75                  80  


Met Gln Arg Leu Asp Met Asp Gly Asp Gly Gln Val Asp Phe Asp Glu 
                85                  90                  95      


Phe Met Thr Ile Leu Gly Pro Lys Leu Val Ser Ser Glu Gly Arg Asp 
            100                 105                 110         


Gly Phe Leu Gly Asn Thr Ile Asp Ser Ile Phe Trp Gln Phe Asp Met 
        115                 120                 125             


Gln Arg Ile Thr Leu Glu Glu Leu Lys His Ile Leu Tyr His Ala Phe 
    130                 135                 140                 


Arg Asp His Leu Thr Met Lys Asp Ile Glu Asn Ile Ile Ile Asn Glu 
145                 150                 155                 160 


Glu Glu Ser Leu Asn Glu Thr Ser Gly Asn Cys Gln Thr Glu Phe Glu 
                165                 170                 175     


Gly Val His Ser Gln Lys Gln Asn Arg Gln Thr Cys Val Arg Lys Ser 
            180                 185                 190         


Leu Ile Cys Ala Phe Ala Met Ala Phe Ile Ile Ser Val Met Leu Ile 
        195                 200                 205             


Ala Ala Asn Gln Ile Leu Arg Ser Gly Met Glu 
    210                 215                 


<210>  1541
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALR3__Homo_sapiens__NP_659483

<400>  1541

Met Ala Arg Ala Leu Val Gln Leu Trp Ala Ile Cys Met Leu Arg Val 
1               5                   10                  15      


Ala Leu Ala Thr Val Tyr Phe Gln Glu Glu Phe Leu Asp Gly Glu His 
            20                  25                  30          


Trp Arg Asn Arg Trp Leu Gln Ser Thr Asn Asp Ser Arg Phe Gly His 
        35                  40                  45              


Phe Arg Leu Ser Ser Gly Lys Phe Tyr Gly His Lys Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Thr Gln Asn Gly Arg Phe Tyr Ala Ile Ser Ala Arg 
65                  70                  75                  80  


Phe Lys Pro Phe Ser Asn Lys Gly Lys Thr Leu Val Ile Gln Tyr Thr 
                85                  90                  95      


Val Lys His Glu Gln Lys Met Asp Cys Gly Gly Gly Tyr Ile Lys Val 
            100                 105                 110         


Phe Pro Ala Asp Ile Asp Gln Lys Asn Leu Asn Gly Lys Ser Gln Tyr 
        115                 120                 125             


Tyr Ile Met Phe Gly Pro Asp Ile Cys Gly Phe Asp Ile Lys Lys Val 
    130                 135                 140                 


His Val Ile Leu His Phe Lys Asn Lys Tyr His Glu Asn Lys Lys Leu 
145                 150                 155                 160 


Ile Arg Cys Lys Val Asp Gly Phe Thr His Leu Tyr Thr Leu Ile Leu 
                165                 170                 175     


Arg Pro Asp Leu Ser Tyr Asp Val Lys Ile Asp Gly Gln Ser Ile Glu 
            180                 185                 190         


Ser Gly Ser Ile Glu Tyr Asp Trp Asn Leu Thr Ser Leu Lys Lys Glu 
        195                 200                 205             


Thr Ser Pro Ala Glu Ser Lys Asp Trp Glu Gln Thr Lys Asp Asn Lys 
    210                 215                 220                 


Ala Gln Asp Trp Glu Lys His Phe Leu Asp Ala Ser Thr Ser Lys Gln 
225                 230                 235                 240 


Ser Asp Trp Asn Gly Asp Leu Asp Gly Asp Trp Pro Ala Pro Met Leu 
                245                 250                 255     


Gln Lys Pro Pro Tyr Gln Asp Gly Leu Lys Pro Glu Gly Ile His Lys 
            260                 265                 270         


Asp Val Trp Leu His Arg Lys Met Lys Asn Thr Asp Tyr Leu Thr Gln 
        275                 280                 285             


Tyr Asp Leu Ser Glu Phe Glu Asn Ile Gly Ala Ile Gly Leu Glu Leu 
    290                 295                 300                 


Trp Gln Val Arg Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asp 
305                 310                 315                 320 


Asp Glu Glu Tyr Ala Asp Asn Phe Gly Lys Ala Thr Trp Gly Glu Thr 
                325                 330                 335     


Lys Gly Pro Glu Arg Glu Met Asp Ala Ile Gln Ala Lys Glu Glu Met 
            340                 345                 350         


Lys Lys Ala Arg Glu Glu Glu Glu Glu Glu Leu Leu Ser Gly Lys Ile 
        355                 360                 365             


Asn Arg His Glu His Tyr Phe Asn Gln Phe His Arg Arg Asn Glu Leu 
    370                 375                 380                 


<210>  1542
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALR__Homo_sapiens__NP_004334

<400>  1542

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  1543
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALU__Homo_sapiens__NP_001124146

<400>  1543

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
1               5                   10                  15      


Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
            20                  25                  30          


Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp 
        35                  40                  45              


His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu 
    50                  55                  60                  


Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Met Ile Val Asp Lys Ile 
65                  70                  75                  80  


Asp Ala Asp Lys Asp Gly Phe Val Thr Glu Gly Glu Leu Lys Ser Trp 
                85                  90                  95      


Ile Lys His Ala Gln Lys Lys Tyr Ile Tyr Asp Asn Val Glu Asn Gln 
            100                 105                 110         


Trp Gln Glu Phe Asp Met Asn Gln Asp Gly Leu Ile Ser Trp Asp Glu 
        115                 120                 125             


Tyr Arg Asn Val Thr Tyr Gly Thr Tyr Leu Asp Asp Pro Asp Pro Asp 
    130                 135                 140                 


Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe 
145                 150                 155                 160 


Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                165                 170                 175     


Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
            180                 185                 190         


Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Phe Ile 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Thr 
    210                 215                 220                 


Asp Glu Pro Glu Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe 
225                 230                 235                 240 


Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp 
                245                 250                 255     


Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His 
            260                 265                 270         


Leu Val Tyr Glu Ser Asp Gln Asn Lys Asp Gly Lys Leu Thr Lys Glu 
        275                 280                 285             


Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp 
    290                 295                 300                 


Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe 
305                 310                 315 


<210>  1544
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CALY__Homo_sapiens__NP_056537

<400>  1544

Met Val Lys Leu Gly Cys Ser Phe Ser Gly Lys Pro Gly Lys Asp Pro 
1               5                   10                  15      


Gly Asp Gln Asp Gly Ala Ala Met Asp Ser Val Pro Leu Ile Ser Pro 
            20                  25                  30          


Leu Asp Ile Ser Gln Leu Gln Pro Pro Leu Pro Asp Gln Val Val Ile 
        35                  40                  45              


Lys Thr Gln Thr Glu Tyr Gln Leu Ser Ser Pro Asp Gln Gln Asn Phe 
    50                  55                  60                  


Pro Asp Leu Glu Gly Gln Arg Leu Asn Cys Ser His Pro Glu Glu Gly 
65                  70                  75                  80  


Arg Arg Leu Pro Thr Ala Arg Met Ile Ala Phe Ala Met Ala Leu Leu 
                85                  90                  95      


Gly Cys Val Leu Ile Met Tyr Lys Ala Ile Trp Tyr Asp Gln Phe Thr 
            100                 105                 110         


Cys Pro Asp Gly Phe Leu Leu Arg His Lys Ile Cys Thr Pro Leu Thr 
        115                 120                 125             


Leu Glu Met Tyr Tyr Thr Glu Met Asp Pro Glu Arg His Arg Ser Ile 
    130                 135                 140                 


Leu Ala Ala Ile Gly Ala Tyr Pro Leu Ser Arg Lys His Gly Thr Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Trp Gly Asp Gly Tyr Arg Ala Ala Lys Glu Glu Arg 
                165                 170                 175     


Lys Gly Pro Thr Gln Ala Gly Ala Ala Ala Ala Ala Thr Glu Pro Pro 
            180                 185                 190         


Gly Lys Pro Ser Ala Lys Ala Glu Lys Glu Ala Ala Arg Lys Ala Ala 
        195                 200                 205             


Gly Ser Ala Ala Pro Pro Pro Ala Gln 
    210                 215         


<210>  1545
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK1D__Homo_sapiens__NP_065130

<400>  1545

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210>  1546
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK1G__Homo_sapiens__NP_065172

<400>  1546

Met Gly Arg Lys Glu Glu Asp Asp Cys Ser Ser Trp Lys Lys Gln Thr 
1               5                   10                  15      


Thr Asn Ile Arg Lys Thr Phe Ile Phe Met Glu Val Leu Gly Ser Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Phe Leu Val Lys Gln Arg Leu Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Leu Lys Cys Ile Lys Lys Ser Pro Ala Phe Arg Asp Ser Ser 
    50                  55                  60                  


Leu Glu Asn Glu Ile Ala Val Leu Lys Lys Ile Lys His Glu Asn Ile 
65                  70                  75                  80  


Val Thr Leu Glu Asp Ile Tyr Glu Ser Thr Thr His Tyr Tyr Leu Val 
                85                  90                  95      


Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Leu Glu Arg 
            100                 105                 110         


Gly Val Tyr Thr Glu Lys Asp Ala Ser Leu Val Ile Gln Gln Val Leu 
        115                 120                 125             


Ser Ala Val Lys Tyr Leu His Glu Asn Gly Ile Val His Arg Asp Leu 
    130                 135                 140                 


Lys Pro Glu Asn Leu Leu Tyr Leu Thr Pro Glu Glu Asn Ser Lys Ile 
145                 150                 155                 160 


Met Ile Thr Asp Phe Gly Leu Ser Lys Met Glu Gln Asn Gly Ile Met 
                165                 170                 175     


Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala 
            180                 185                 190         


Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile 
        195                 200                 205             


Thr Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Glu Glu Thr Glu 
    210                 215                 220                 


Ser Lys Leu Phe Glu Lys Ile Lys Glu Gly Tyr Tyr Glu Phe Glu Ser 
225                 230                 235                 240 


Pro Phe Trp Asp Asp Ile Ser Glu Ser Ala Lys Asp Phe Ile Cys His 
                245                 250                 255     


Leu Leu Glu Lys Asp Pro Asn Glu Arg Tyr Thr Cys Glu Lys Ala Leu 
            260                 265                 270         


Ser His Pro Trp Ile Asp Gly Asn Thr Ala Leu His Arg Asp Ile Tyr 
        275                 280                 285             


Pro Ser Val Ser Leu Gln Ile Gln Lys Asn Phe Ala Lys Ser Lys Trp 
    290                 295                 300                 


Arg Gln Ala Phe Asn Ala Ala Ala Val Val His His Met Arg Lys Leu 
305                 310                 315                 320 


His Met Asn Leu His Ser Pro Gly Val Arg Pro Glu Val Glu Asn Arg 
                325                 330                 335     


Pro Pro Glu Thr Gln Ala Ser Glu Thr Ser Arg Pro Ser Ser Pro Glu 
            340                 345                 350         


Ile Thr Ile Thr Glu Ala Pro Val Leu Asp His Ser Val Ala Leu Pro 
        355                 360                 365             


Ala Leu Thr Gln Leu Pro Cys Gln His Gly Arg Arg Pro Thr Ala Pro 
    370                 375                 380                 


Gly Gly Arg Ser Leu Asn Cys Leu Val Asn Gly Ser Leu His Ile Ser 
385                 390                 395                 400 


Ser Ser Leu Val Pro Met His Gln Gly Ser Leu Ala Ala Gly Pro Cys 
                405                 410                 415     


Gly Cys Cys Ser Ser Cys Leu Asn Ile Gly Ser Lys Gly Lys Ser Ser 
            420                 425                 430         


Tyr Cys Ser Glu Pro Thr Leu Leu Lys Lys Ala Asn Lys Lys Gln Asn 
        435                 440                 445             


Phe Lys Ser Glu Val Met Val Pro Val Lys Ala Ser Gly Ser Ser His 
    450                 455                 460                 


Cys Arg Ala Gly Gln Thr Gly Val Cys Leu Ile Met 
465                 470                 475     


<210>  1547
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK1__Homo_sapiens__NP_003647

<400>  1547

Met Leu Gly Ala Val Glu Gly Pro Arg Trp Lys Gln Ala Glu Asp Ile 
1               5                   10                  15      


Arg Asp Ile Tyr Asp Phe Arg Asp Val Leu Gly Thr Gly Ala Phe Ser 
            20                  25                  30          


Glu Val Ile Leu Ala Glu Asp Lys Arg Thr Gln Lys Leu Val Ala Ile 
        35                  40                  45              


Lys Cys Ile Ala Lys Glu Ala Leu Glu Gly Lys Glu Gly Ser Met Glu 
    50                  55                  60                  


Asn Glu Ile Ala Val Leu His Lys Ile Lys His Pro Asn Ile Val Ala 
65                  70                  75                  80  


Leu Asp Asp Ile Tyr Glu Ser Gly Gly His Leu Tyr Leu Ile Met Gln 
                85                  90                  95      


Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu Lys Gly Phe 
            100                 105                 110         


Tyr Thr Glu Arg Asp Ala Ser Arg Leu Ile Phe Gln Val Leu Asp Ala 
        115                 120                 125             


Val Lys Tyr Leu His Asp Leu Gly Ile Val His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu Asn Leu Leu Tyr Tyr Ser Leu Asp Glu Asp Ser Lys Ile Met Ile 
145                 150                 155                 160 


Ser Asp Phe Gly Leu Ser Lys Met Glu Asp Pro Gly Ser Val Leu Ser 
                165                 170                 175     


Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val Leu Ala Gln 
            180                 185                 190         


Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly Val Ile Ala 
        195                 200                 205             


Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu Asn Asp Ala 
    210                 215                 220                 


Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe Asp Ser Pro 
225                 230                 235                 240 


Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile Arg His Leu 
                245                 250                 255     


Met Glu Lys Asp Pro Glu Lys Arg Phe Thr Cys Glu Gln Ala Leu Gln 
            260                 265                 270         


His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asp Lys Asn Ile His Gln 
        275                 280                 285             


Ser Val Ser Glu Gln Ile Lys Lys Asn Phe Ala Lys Ser Lys Trp Lys 
    290                 295                 300                 


Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg Lys Leu Gln 
305                 310                 315                 320 


Leu Gly Thr Ser Gln Glu Gly Gln Gly Gln Thr Ala Ser His Gly Glu 
                325                 330                 335     


Leu Leu Thr Pro Val Ala Gly Gly Pro Ala Ala Gly Cys Cys Cys Arg 
            340                 345                 350         


Asp Cys Cys Val Glu Pro Gly Thr Glu Leu Ser Pro Thr Leu Pro His 
        355                 360                 365             


Gln Leu 
    370 


<210>  1548
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK2A__Homo_sapiens__NP_057065

<400>  1548

Met Ala Thr Ile Thr Cys Thr Arg Phe Thr Glu Glu Tyr Gln Leu Phe 
1               5                   10                  15      


Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val Lys 
            20                  25                  30          


Val Leu Ala Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys Lys 
        35                  40                  45              


Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile Cys 
    50                  55                  60                  


Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile Ser 
65                  70                  75                  80  


Glu Glu Gly His His Tyr Leu Ile Phe Asp Leu Val Thr Gly Gly Glu 
                85                  90                  95      


Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp Ala 
            100                 105                 110         


Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His Gln 
        115                 120                 125             


Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu Ala 
    130                 135                 140                 


Ser Lys Leu Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu Ala 
145                 150                 155                 160 


Ile Glu Val Glu Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly Thr 
                165                 170                 175     


Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly Lys 
            180                 185                 190         


Pro Val Asp Leu Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu Val 
        195                 200                 205             


Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln Gln 
    210                 215                 220                 


Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr Val 
225                 230                 235                 240 


Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn Pro 
                245                 250                 255     


Ser Lys Arg Ile Thr Ala Ala Glu Ala Leu Lys His Pro Trp Ile Ser 
            260                 265                 270         


His Arg Ser Thr Val Ala Ser Cys Met His Arg Gln Glu Thr Val Asp 
        275                 280                 285             


Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu 
    290                 295                 300                 


Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Gly Gly Lys Ser Gly Gly 
305                 310                 315                 320 


Asn Lys Lys Ser Asp Gly Val Lys Lys Arg Lys Ser Ser Ser Ser Val 
                325                 330                 335     


Gln Leu Met Glu Ser Ser Glu Ser Thr Asn Thr Thr Ile Glu Asp Glu 
            340                 345                 350         


Asp Thr Lys Val Arg Lys Gln Glu Ile Ile Lys Val Thr Glu Gln Leu 
        355                 360                 365             


Ile Glu Ala Ile Ser Asn Gly Asp Phe Glu Ser Tyr Thr Lys Met Cys 
    370                 375                 380                 


Asp Pro Gly Met Thr Ala Phe Glu Pro Glu Ala Leu Gly Asn Leu Val 
385                 390                 395                 400 


Glu Gly Leu Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Trp Ser Arg 
                405                 410                 415     


Asn Ser Lys Pro Val His Thr Thr Ile Leu Asn Pro His Ile His Leu 
            420                 425                 430         


Met Gly Asp Glu Ser Ala Cys Ile Ala Tyr Ile Arg Ile Thr Gln Tyr 
        435                 440                 445             


Leu Asp Ala Gly Gly Ile Pro Arg Thr Ala Gln Ser Glu Glu Thr Arg 
    450                 455                 460                 


Val Trp His Arg Arg Asp Gly Lys Trp Gln Ile Val His Phe His Arg 
465                 470                 475                 480 


Ser Gly Ala Pro Ser Val Leu Pro His 
                485                 


<210>  1549
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK2B__Homo_sapiens__NP_001211

<400>  1549

Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His 
        115                 120                 125             


Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr 
305                 310                 315                 320 


Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly 
                325                 330                 335     


Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val 
            340                 345                 350         


Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro 
        355                 360                 365             


Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile 
    370                 375                 380                 


His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr 
385                 390                 395                 400 


Thr Ile Glu Asp Glu Asp Ala Lys Ala Pro Arg Val Pro Asp Ile Leu 
                405                 410                 415     


Ser Ser Val Arg Arg Gly Ser Gly Ala Pro Glu Ala Glu Gly Pro Leu 
            420                 425                 430         


Pro Cys Pro Ser Pro Ala Pro Phe Ser Pro Leu Pro Ala Pro Ser Pro 
        435                 440                 445             


Arg Ile Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro 
    450                 455                 460                 


Glu Ala Glu Gly Pro Leu Ser Ala Gly Pro Pro Pro Cys Leu Ser Pro 
465                 470                 475                 480 


Ala Leu Leu Gly Pro Leu Ser Ser Pro Ser Pro Arg Ile Ser Asp Ile 
                485                 490                 495     


Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu Ala Glu Gly Pro 
            500                 505                 510         


Ser Pro Val Gly Pro Pro Pro Cys Pro Ser Pro Thr Ile Pro Gly Pro 
        515                 520                 525             


Leu Pro Thr Pro Ser Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln 
    530                 535                 540                 


Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile 
545                 550                 555                 560 


Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu 
                565                 570                 575     


Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala 
            580                 585                 590         


Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His 
        595                 600                 605             


Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln 
    610                 615                 620                 


Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr 
625                 630                 635                 640 


Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His 
                645                 650                 655     


Cys Ser Gly Ala Pro Val Ala Pro Leu Gln 
            660                 665     


<210>  1550
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK2D__Homo_sapiens__NP_001212

<400>  1550

Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met 
            20                  25                  30          


Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His 
        115                 120                 125             


Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr 
                325                 330                 335     


Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys 
            340                 345                 350         


Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala 
        355                 360                 365             


Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala 
    370                 375                 380                 


Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu 
385                 390                 395                 400 


Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn 
                405                 410                 415     


Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile 
            420                 425                 430         


Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln 
        435                 440                 445             


Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn 
    450                 455                 460                 


Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro 
465                 470                 475                 480 


Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp 
                485                 490                 495     


Gln Asn Ile 
            


<210>  1551
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK2G__Homo_sapiens__NP_001213

<400>  1551

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Ala Ala Lys Ser Leu 
305                 310                 315                 320 


Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Glu Pro Gln Thr Thr Val 
                325                 330                 335     


Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
            340                 345                 350         


Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
        355                 360                 365             


Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
    370                 375                 380                 


Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
385                 390                 395                 400 


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
                405                 410                 415     


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
            420                 425                 430         


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
        435                 440                 445             


Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
    450                 455                 460                 


Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
465                 470                 475                 480 


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
                485                 490                 495 


<210>  1552
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMK4__Homo_sapiens__NP_001735

<400>  1552

Met Leu Lys Val Thr Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15      


Val Thr Ala Ser Ala Ala Pro Gly Thr Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30          


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45              


Glu Ser Glu Leu Gly Arg Gly Ala Thr Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60                  


Gln Lys Gly Thr Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Thr 
65                  70                  75                  80  


Val Asp Lys Lys Ile Val Arg Thr Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95      


Ser His Pro Asn Ile Ile Lys Leu Lys Glu Ile Phe Glu Thr Pro Thr 
            100                 105                 110         


Glu Ile Ser Leu Val Leu Glu Leu Val Thr Gly Gly Glu Leu Phe Asp 
        115                 120                 125             


Arg Ile Val Glu Lys Gly Tyr Tyr Ser Glu Arg Asp Ala Ala Asp Ala 
    130                 135                 140                 


Val Lys Gln Ile Leu Glu Ala Val Ala Tyr Leu His Glu Asn Gly Ile 
145                 150                 155                 160 


Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Tyr Ala Thr Pro Ala 
                165                 170                 175     


Pro Asp Ala Pro Leu Lys Ile Ala Asp Phe Gly Leu Ser Lys Ile Val 
            180                 185                 190         


Glu His Gln Val Leu Met Lys Thr Val Cys Gly Thr Pro Gly Tyr Cys 
        195                 200                 205             


Ala Pro Glu Ile Leu Arg Gly Cys Ala Tyr Gly Pro Glu Val Asp Met 
    210                 215                 220                 


Trp Ser Val Gly Ile Ile Thr Tyr Ile Leu Leu Cys Gly Phe Glu Pro 
225                 230                 235                 240 


Phe Tyr Asp Glu Arg Gly Asp Gln Phe Met Phe Arg Arg Ile Leu Asn 
                245                 250                 255     


Cys Glu Tyr Tyr Phe Ile Ser Pro Trp Trp Asp Glu Val Ser Leu Asn 
            260                 265                 270         


Ala Lys Asp Leu Val Arg Lys Leu Ile Val Leu Asp Pro Lys Lys Arg 
        275                 280                 285             


Leu Thr Thr Phe Gln Ala Leu Gln His Pro Trp Val Thr Gly Lys Ala 
    290                 295                 300                 


Ala Asn Phe Val His Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe 
305                 310                 315                 320 


Asn Ala Arg Arg Lys Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser 
                325                 330                 335     


Ser Arg Leu Gly Ser Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser 
            340                 345                 350         


His Lys Ala Ser Arg Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp 
        355                 360                 365             


Met Lys Ala Ile Pro Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln 
    370                 375                 380                 


Ala Ala Val Lys Gly Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu 
385                 390                 395                 400 


Glu Lys Val Lys Gly Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met 
                405                 410                 415     


Val Pro Lys Ala Val Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu 
            420                 425                 430         


Glu Glu Gly Leu Ala Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala 
        435                 440                 445             


Ala Pro Arg Glu Gly Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro 
    450                 455                 460                 


Gln Gln Asp Val Ile Leu Pro Glu Tyr 
465                 470             


<210>  1553
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMKK1__Homo_sapiens__NP_757343

<400>  1553

Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210>  1554
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMKK2__Homo_sapiens__NP_001257414

<400>  1554

Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly His Arg 
    530                 535                 540                 


Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu Val Arg Gly Ser Pro 
545                 550                 555                 560 


Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly Ser Pro Ala Arg Met 
                565                 570                 575     


His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585             


<210>  1555
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMKMT__Homo_sapiens__NP_079042

<400>  1555

Met Glu Ser Arg Val Ala Asp Ala Gly Thr Gly Glu Thr Ala Arg Ala 
1               5                   10                  15      


Ala Gly Gly Ser Pro Ala Val Gly Cys Thr Thr Arg Gly Pro Val Val 
            20                  25                  30          


Ser Ala Pro Leu Gly Ala Ala Arg Trp Lys Leu Leu Arg Gln Val Leu 
        35                  40                  45              


Lys Gln Lys His Leu Asp Asp Cys Leu Arg His Val Ser Val Arg Arg 
    50                  55                  60                  


Phe Glu Ser Phe Asn Leu Phe Ser Val Thr Glu Gly Lys Glu Arg Glu 
65                  70                  75                  80  


Thr Glu Glu Glu Val Gly Ala Trp Val Gln Tyr Thr Ser Ile Phe Cys 
                85                  90                  95      


Pro Glu Tyr Ser Ile Ser Leu Arg His Asn Ser Gly Ser Leu Asn Val 
            100                 105                 110         


Glu Asp Val Leu Thr Ser Phe Asp Asn Thr Gly Asn Val Cys Ile Trp 
        115                 120                 125             


Pro Ser Glu Glu Val Leu Ala Tyr Tyr Cys Leu Lys His Asn Asn Ile 
    130                 135                 140                 


Phe Arg Ala Leu Ala Val Cys Glu Leu Gly Gly Gly Met Thr Cys Leu 
145                 150                 155                 160 


Ala Gly Leu Met Val Ala Ile Ser Ala Asp Val Lys Glu Val Leu Leu 
                165                 170                 175     


Thr Asp Gly Asn Glu Lys Ala Ile Arg Asn Val Gln Asp Ile Ile Thr 
            180                 185                 190         


Arg Asn Gln Lys Ala Gly Val Phe Lys Thr Gln Lys Ile Ser Ser Cys 
        195                 200                 205             


Val Leu Arg Trp Asp Asn Glu Thr Asp Val Ser Gln Leu Glu Gly His 
    210                 215                 220                 


Phe Asp Ile Val Met Cys Ala Asp Cys Leu Phe Leu Asp Gln Tyr Arg 
225                 230                 235                 240 


Ala Ser Leu Val Asp Ala Ile Lys Arg Leu Leu Gln Pro Arg Gly Lys 
                245                 250                 255     


Ala Met Val Phe Ala Pro Arg Arg Gly Asn Thr Leu Asn Gln Phe Cys 
            260                 265                 270         


Asn Leu Ala Glu Lys Ala Gly Phe Cys Ile Gln Arg His Glu Asn Tyr 
        275                 280                 285             


Asp Glu His Ile Ser Asn Phe His Ser Lys Leu Lys Lys Glu Asn Pro 
    290                 295                 300                 


Asp Ile Tyr Glu Glu Asn Leu His Tyr Pro Leu Leu Leu Ile Leu Thr 
305                 310                 315                 320 


Lys His Gly 
            


<210>  1556
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMLG__Homo_sapiens__NP_001736

<400>  1556

Met Glu Ser Met Ala Val Ala Thr Asp Gly Gly Glu Arg Pro Gly Val 
1               5                   10                  15      


Pro Ala Gly Ser Gly Leu Ser Ala Ser Gln Arg Arg Ala Glu Leu Arg 
            20                  25                  30          


Arg Arg Lys Leu Leu Met Asn Ser Glu Gln Arg Ile Asn Arg Ile Met 
        35                  40                  45              


Gly Phe His Arg Pro Gly Ser Gly Ala Glu Glu Glu Ser Gln Thr Lys 
    50                  55                  60                  


Ser Lys Gln Gln Asp Ser Asp Lys Leu Asn Ser Leu Ser Val Pro Ser 
65                  70                  75                  80  


Val Ser Lys Arg Val Val Leu Gly Asp Ser Val Ser Thr Gly Thr Thr 
                85                  90                  95      


Asp Gln Gln Gly Gly Val Ala Glu Val Lys Gly Thr Gln Leu Gly Asp 
            100                 105                 110         


Lys Leu Asp Ser Phe Ile Lys Pro Pro Glu Cys Ser Ser Asp Val Asn 
        115                 120                 125             


Leu Glu Leu Arg Gln Arg Asn Arg Gly Asp Leu Thr Ala Asp Ser Val 
    130                 135                 140                 


Gln Arg Gly Ser Arg His Gly Leu Glu Gln Tyr Leu Ser Arg Phe Glu 
145                 150                 155                 160 


Glu Ala Met Lys Leu Arg Lys Gln Leu Ile Ser Glu Lys Pro Ser Gln 
                165                 170                 175     


Glu Asp Gly Asn Thr Thr Glu Glu Phe Asp Ser Phe Arg Ile Phe Arg 
            180                 185                 190         


Leu Val Gly Cys Ala Leu Leu Ala Leu Gly Val Arg Ala Phe Val Cys 
        195                 200                 205             


Lys Tyr Leu Ser Ile Phe Ala Pro Phe Leu Thr Leu Gln Leu Ala Tyr 
    210                 215                 220                 


Met Gly Leu Tyr Lys Tyr Phe Pro Lys Ser Glu Lys Lys Ile Lys Thr 
225                 230                 235                 240 


Thr Val Leu Thr Ala Ala Leu Leu Leu Ser Gly Ile Pro Ala Glu Val 
                245                 250                 255     


Ile Asn Arg Ser Met Asp Thr Tyr Ser Lys Met Gly Glu Val Phe Thr 
            260                 265                 270         


Asp Leu Cys Val Tyr Phe Phe Thr Phe Ile Phe Cys His Glu Leu Leu 
        275                 280                 285             


Asp Tyr Trp Gly Ser Glu Val Pro 
    290                 295     


<210>  1557
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMP__Homo_sapiens__NP_004336

<400>  1557

Met Gly Thr Met Lys Thr Gln Arg Asp Gly His Ser Leu Gly Arg Trp 
1               5                   10                  15      


Ser Leu Val Leu Leu Leu Leu Gly Leu Val Met Pro Leu Ala Ile Ile 
            20                  25                  30          


Ala Gln Val Leu Ser Tyr Lys Glu Ala Val Leu Arg Ala Ile Asp Gly 
        35                  40                  45              


Ile Asn Gln Arg Ser Ser Asp Ala Asn Leu Tyr Arg Leu Leu Asp Leu 
    50                  55                  60                  


Asp Pro Arg Pro Thr Met Asp Gly Asp Pro Asp Thr Pro Lys Pro Val 
65                  70                  75                  80  


Ser Phe Thr Val Lys Glu Thr Val Cys Pro Arg Thr Thr Gln Gln Ser 
                85                  90                  95      


Pro Glu Asp Cys Asp Phe Lys Lys Asp Gly Leu Val Lys Arg Cys Met 
            100                 105                 110         


Gly Thr Val Thr Leu Asn Gln Ala Arg Gly Ser Phe Asp Ile Ser Cys 
        115                 120                 125             


Asp Lys Asp Asn Lys Arg Phe Ala Leu Leu Gly Asp Phe Phe Arg Lys 
    130                 135                 140                 


Ser Lys Glu Lys Ile Gly Lys Glu Phe Lys Arg Ile Val Gln Arg Ile 
145                 150                 155                 160 


Lys Asp Phe Leu Arg Asn Leu Val Pro Arg Thr Glu Ser 
                165                 170             


<210>  1558
<211>  1602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMSAP1__Homo_sapiens__NP_056262

<400>  1558

Met Val Asp Ala Ser Gly Arg Ala Ala Ala Glu Gly Trp Arg Lys Met 
1               5                   10                  15      


Glu Ala Pro Pro Asp Gly Ala Ala Asp Leu Val Pro Leu Asp Arg Tyr 
            20                  25                  30          


Asp Ala Ala Arg Ala Lys Ile Ala Ala Asn Leu Gln Trp Ile Cys Ala 
        35                  40                  45              


Lys Ala Tyr Gly Arg Asp Asn Ile Pro Glu Asp Leu Arg Asp Pro Phe 
    50                  55                  60                  


Tyr Val Asp Gln Tyr Glu Gln Glu His Ile Lys Pro Pro Val Ile Lys 
65                  70                  75                  80  


Leu Leu Leu Ser Ser Glu Leu Tyr Cys Arg Val Cys Ser Leu Ile Leu 
                85                  90                  95      


Lys Gly Asp Gln Val Ala Ala Leu Gln Gly His Gln Ser Val Ile Gln 
            100                 105                 110         


Ala Leu Ser Arg Lys Gly Ile Tyr Val Met Glu Ser Asp Asp Thr Pro 
        115                 120                 125             


Val Thr Glu Ser Asp Leu Ser Arg Ala Pro Ile Lys Met Ser Ala His 
    130                 135                 140                 


Met Ala Met Val Asp Ala Leu Met Met Ala Tyr Thr Val Glu Met Ile 
145                 150                 155                 160 


Ser Ile Glu Lys Val Val Ala Ser Val Lys Arg Phe Ser Thr Phe Ser 
                165                 170                 175     


Ala Ser Lys Glu Leu Pro Tyr Asp Leu Glu Asp Ala Met Val Phe Trp 
            180                 185                 190         


Ile Asn Lys Val Asn Leu Lys Met Arg Glu Ile Thr Glu Lys Glu Val 
        195                 200                 205             


Lys Leu Lys Gln Gln Leu Leu Glu Ser Pro Ala His Gln Lys Val Arg 
    210                 215                 220                 


Tyr Arg Arg Glu His Leu Ser Ala Arg Gln Ser Pro Tyr Phe Pro Leu 
225                 230                 235                 240 


Leu Glu Asp Leu Met Arg Asp Gly Ser Asp Gly Ala Ala Leu Leu Ala 
                245                 250                 255     


Val Ile His Tyr Tyr Cys Pro Glu Gln Met Lys Leu Asp Asp Ile Cys 
            260                 265                 270         


Leu Lys Glu Val Thr Ser Met Ala Asp Ser Leu Tyr Asn Ile Arg Leu 
        275                 280                 285             


Leu Arg Glu Phe Ser Asn Glu Tyr Leu Asn Lys Cys Phe Tyr Leu Thr 
    290                 295                 300                 


Leu Glu Asp Met Leu Tyr Ala Pro Leu Val Leu Lys Pro Asn Val Met 
305                 310                 315                 320 


Val Phe Ile Ala Glu Leu Phe Trp Trp Phe Glu Asn Val Lys Pro Asp 
                325                 330                 335     


Phe Val Gln Pro Arg Asp Val Gln Glu Leu Lys Asp Ala Lys Thr Val 
            340                 345                 350         


Leu His Gln Lys Ser Ser Arg Pro Pro Val Pro Ile Ser Asn Ala Thr 
        355                 360                 365             


Lys Arg Ser Phe Leu Gly Ser Pro Ala Ala Gly Thr Leu Ala Glu Leu 
    370                 375                 380                 


Gln Pro Pro Val Gln Leu Pro Ala Glu Gly Cys His Arg His Tyr Leu 
385                 390                 395                 400 


His Pro Glu Glu Pro Glu Tyr Leu Gly Lys Gly Thr Ala Ala Phe Ser 
                405                 410                 415     


Pro Ser His Pro Leu Leu Pro Leu Arg Gln Lys Gln Gln Lys Ser Ile 
            420                 425                 430         


Gln Gly Glu Asp Ile Pro Asp Gln Arg His Arg Ser Asn Ser Leu Thr 
        435                 440                 445             


Arg Val Asp Gly Gln Pro Arg Gly Ala Ala Ile Ala Trp Pro Glu Lys 
    450                 455                 460                 


Lys Thr Arg Pro Ala Ser Gln Pro Thr Pro Phe Ala Leu His His Ala 
465                 470                 475                 480 


Ala Ser Cys Glu Val Asp Pro Ser Ser Gly Asp Ser Ile Ser Leu Ala 
                485                 490                 495     


Arg Ser Ile Ser Lys Asp Ser Leu Ala Ser Asn Ile Val Asn Leu Thr 
            500                 505                 510         


Pro Gln Asn Gln Pro His Pro Thr Ala Thr Lys Ser His Gly Lys Ser 
        515                 520                 525             


Leu Leu Ser Asn Val Ser Ile Glu Asp Glu Glu Glu Glu Leu Val Ala 
    530                 535                 540                 


Ile Val Arg Ala Asp Val Val Pro Gln Gln Ala Asp Pro Glu Phe Pro 
545                 550                 555                 560 


Arg Ala Ser Pro Arg Ala Leu Gly Leu Thr Ala Asn Ala Arg Ser Pro 
                565                 570                 575     


Gln Gly Gln Leu Asp Thr Ser Glu Ser Lys Pro Asp Ser Phe Phe Leu 
            580                 585                 590         


Glu Pro Leu Met Pro Ala Val Leu Lys Pro Ala Lys Glu Lys Gln Val 
        595                 600                 605             


Ile Thr Lys Glu Asp Glu Arg Gly Glu Gly Arg Pro Arg Ser Ile Val 
    610                 615                 620                 


Ser Arg Arg Pro Ser Glu Gly Pro Gln Pro Leu Val Arg Arg Lys Met 
625                 630                 635                 640 


Thr Gly Ser Arg Asp Leu Asn Arg Thr Phe Thr Pro Ile Pro Cys Ser 
                645                 650                 655     


Glu Phe Pro Met Gly Ile Asp Pro Thr Glu Thr Gly Pro Leu Ser Val 
            660                 665                 670         


Glu Thr Ala Gly Glu Val Cys Gly Gly Pro Leu Ala Leu Gly Gly Phe 
        675                 680                 685             


Asp Pro Phe Pro Gln Gly Pro Ser Thr Asp Gly Phe Phe Leu His Val 
    690                 695                 700                 


Gly Arg Ala Asp Glu Asp Thr Glu Gly Arg Leu Tyr Val Ser Cys Ser 
705                 710                 715                 720 


Lys Ser Pro Asn Ser His Asp Ser Glu Pro Trp Thr Leu Leu Arg Gln 
                725                 730                 735     


Asp Ser Asp Ser Asp Val Val Asp Ile Glu Glu Ala Glu His Asp Phe 
            740                 745                 750         


Met Gly Glu Ala His Pro Val Val Phe Ser Arg Tyr Ile Gly Glu Glu 
        755                 760                 765             


Glu Ser Ala Lys Leu Gln Glu Asp Met Lys Val Lys Glu His Glu Asp 
    770                 775                 780                 


Lys Asp Asp Ala Ser Gly Arg Ser Ser Pro Cys Leu Ser Thr Ala Ser 
785                 790                 795                 800 


Gln Met Ser Ser Val Ser Met Ala Ser Gly Ser Val Lys Met Thr Ser 
                805                 810                 815     


Phe Ala Glu Arg Lys Leu Gln Arg Leu Asn Ser Cys Glu Thr Lys Ser 
            820                 825                 830         


Ser Thr Ser Ser Ser Gln Lys Thr Thr Pro Asp Ala Ser Glu Ser Cys 
        835                 840                 845             


Pro Ala Pro Leu Thr Thr Trp Arg Gln Lys Arg Glu Gln Ser Pro Ser 
    850                 855                 860                 


Gln His Gly Lys Asp Pro Ala Ser Leu Leu Ala Ser Glu Leu Val Gln 
865                 870                 875                 880 


Leu His Met Gln Leu Glu Glu Lys Arg Arg Ala Ile Glu Ala Gln Lys 
                885                 890                 895     


Lys Lys Met Glu Ala Leu Ser Ala Arg Gln Arg Leu Lys Leu Gly Lys 
            900                 905                 910         


Ala Ala Phe Leu His Val Val Lys Lys Gly Lys Ala Glu Ala Ala Pro 
        915                 920                 925             


Pro Leu Arg Pro Glu His Phe Ala Lys Glu Tyr Ser Gln His Asn Gly 
    930                 935                 940                 


Glu Asp Cys Gly Asp Ala Val Ser Lys Thr Glu Asp Phe Leu Val Lys 
945                 950                 955                 960 


Glu Glu Gln Arg Glu Glu Leu Leu His Glu Pro Gln Asp Val Asp Lys 
                965                 970                 975     


Glu Ser Leu Ala Phe Ala Gln Gln His Lys Ala Lys Asp Pro Val Ala 
            980                 985                 990         


Leu His Glu Leu Glu Arg Asn Lys  Val Ile Ser Ala Ala  Leu Leu Glu 
        995                 1000                 1005             


Asp Thr  Val Gly Glu Val Val  Asp Val Asn Glu Cys  Asp Leu Ser 
    1010                 1015                 1020             


Ile Glu  Lys Leu Asn Glu Thr  Ile Ser Thr Leu Gln  Gln Ala Ile 
    1025                 1030                 1035             


Leu Lys  Ile Ser Gln Gln Gln  Glu Gln Leu Leu Met  Lys Ser Pro 
    1040                 1045                 1050             


Thr Val  Pro Val Pro Gly Ser  Lys Asn Asn Ser Gln  Asp His Lys 
    1055                 1060                 1065             


Val Lys  Ala Pro Val His Phe  Val Glu Pro Leu Ser  Pro Thr Gly 
    1070                 1075                 1080             


Val Ala  Gly His Arg Lys Ala  Pro Arg Leu Gly Gln  Gly Arg Asn 
    1085                 1090                 1095             


Ser Arg  Ser Gly Arg Pro Ala  Glu Leu Lys Val Pro  Lys Asp Arg 
    1100                 1105                 1110             


Pro Gln  Gly Ser Ser Arg Ser  Lys Thr Pro Thr Pro  Ser Val Glu 
    1115                 1120                 1125             


Thr Leu  Pro His Leu Arg Pro  Phe Pro Ala Ser Ser  His Pro Arg 
    1130                 1135                 1140             


Thr Pro  Thr Asp Pro Gly Leu  Asp Ser Ala Leu Glu  Pro Ser Gly 
    1145                 1150                 1155             


Asp Pro  His Gly Lys Cys Leu  Phe Asp Ser Tyr Arg  Leu His Asp 
    1160                 1165                 1170             


Glu Ser  Asn Gln Arg Thr Leu  Thr Leu Ser Ser Ser  Lys Asp Ala 
    1175                 1180                 1185             


Asn Ile  Leu Ser Glu Gln Met  Ser Leu Lys Glu Val  Leu Asp Ala 
    1190                 1195                 1200             


Ser Val  Lys Glu Val Gly Ser  Ser Ser Ser Asp Val  Ser Gly Lys 
    1205                 1210                 1215             


Glu Ser  Val Pro Val Glu Glu  Pro Leu Arg Ser Arg  Ala Ser Leu 
    1220                 1225                 1230             


Ile Glu  Val Asp Leu Ser Asp  Leu Lys Ala Pro Asp  Glu Asp Gly 
    1235                 1240                 1245             


Glu Leu  Val Ser Leu Asp Gly  Ser Ala Asp Leu Val  Ser Glu Gly 
    1250                 1255                 1260             


Asp Gln  Lys Pro Gly Val Gly  Phe Phe Phe Lys Asp  Glu Gln Lys 
    1265                 1270                 1275             


Ala Glu  Asp Glu Leu Ala Lys  Lys Arg Ala Ala Phe  Leu Leu Lys 
    1280                 1285                 1290             


Gln Gln  Arg Lys Ala Glu Glu  Ala Arg Val Arg Lys  Gln Gln Leu 
    1295                 1300                 1305             


Glu Ala  Glu Val Glu Leu Lys  Arg Asp Glu Ala Arg  Arg Lys Ala 
    1310                 1315                 1320             


Glu Glu  Asp Arg Val Arg Lys  Glu Glu Glu Lys Ala  Arg Arg Glu 
    1325                 1330                 1335             


Leu Ile  Lys Gln Glu Tyr Leu  Arg Arg Lys Gln Gln  Gln Ile Leu 
    1340                 1345                 1350             


Glu Glu  Gln Gly Leu Gly Lys  Pro Lys Ser Lys Pro  Lys Lys Pro 
    1355                 1360                 1365             


Arg Pro  Lys Ser Val His Arg  Glu Glu Ser Cys Ser  Asp Ser Gly 
    1370                 1375                 1380             


Thr Lys  Cys Ser Ser Thr Pro  Asp Asn Leu Ser Arg  Thr Gln Ser 
    1385                 1390                 1395             


Gly Ser  Ser Leu Ser Leu Ala  Ser Ala Ala Thr Thr  Glu Pro Glu 
    1400                 1405                 1410             


Ser Val  His Ser Gly Gly Thr  Pro Ser Gln Arg Val  Glu Ser Met 
    1415                 1420                 1425             


Glu Ala  Leu Pro Ile Leu Ser  Arg Asn Pro Ser Arg  Ser Thr Asp 
    1430                 1435                 1440             


Arg Asp  Trp Glu Thr Ala Ser  Ala Ala Ser Ser Leu  Ala Ser Val 
    1445                 1450                 1455             


Ala Glu  Tyr Thr Gly Pro Lys  Leu Phe Lys Glu Pro  Ser Ser Lys 
    1460                 1465                 1470             


Ser Asn  Lys Pro Ile Ile His  Asn Ala Ile Ser His  Cys Cys Leu 
    1475                 1480                 1485             


Ala Gly  Lys Val Asn Glu Pro  His Lys Asn Ser Ile  Leu Glu Glu 
    1490                 1495                 1500             


Leu Glu  Lys Cys Asp Ala Asn  His Tyr Ile Ile Leu  Phe Arg Asp 
    1505                 1510                 1515             


Ala Gly  Cys Gln Phe Arg Ala  Leu Tyr Cys Tyr Tyr  Pro Asp Thr 
    1520                 1525                 1530             


Glu Glu  Ile Tyr Lys Leu Thr  Gly Thr Gly Pro Lys  Asn Ile Thr 
    1535                 1540                 1545             


Lys Lys  Met Ile Asp Lys Leu  Tyr Lys Tyr Ser Ser  Asp Arg Lys 
    1550                 1555                 1560             


Gln Phe  Asn Leu Ile Pro Ala  Lys Thr Met Ser Val  Ser Val Asp 
    1565                 1570                 1575             


Ala Leu  Thr Ile His Asn His  Leu Trp Gln Pro Lys  Arg Pro Ala 
    1580                 1585                 1590             


Val Pro  Lys Lys Ala Gln Thr  Arg Lys 
    1595                 1600         


<210>  1559
<211>  1489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMSAP2__Homo_sapiens__NP_001284636

<400>  1559

Met Gly Asp Ala Ala Asp Pro Arg Glu Met Arg Lys Thr Phe Ile Val 
1               5                   10                  15      


Pro Ala Ile Lys Pro Phe Asp His Tyr Asp Phe Ser Arg Ala Lys Ile 
            20                  25                  30          


Ala Cys Asn Leu Ala Trp Leu Val Ala Lys Ala Phe Gly Thr Glu Asn 
        35                  40                  45              


Val Pro Glu Glu Leu Gln Glu Pro Phe Tyr Thr Asp Gln Tyr Asp Gln 
    50                  55                  60                  


Glu His Ile Lys Pro Pro Val Val Asn Leu Leu Leu Ser Ala Glu Leu 
65                  70                  75                  80  


Tyr Cys Arg Ala Gly Ser Leu Ile Leu Lys Ser Asp Ala Ala Lys Pro 
                85                  90                  95      


Leu Leu Gly His Asp Ala Val Ile Gln Ala Leu Ala Gln Lys Gly Leu 
            100                 105                 110         


Tyr Val Thr Asp Gln Glu Lys Leu Val Thr Glu Arg Asp Leu His Lys 
        115                 120                 125             


Lys Pro Ile Gln Met Ser Ala His Leu Ala Met Ile Asp Thr Leu Met 
    130                 135                 140                 


Met Ala Tyr Thr Val Glu Met Val Ser Ile Glu Lys Val Ile Ala Cys 
145                 150                 155                 160 


Ala Gln Gln Tyr Ser Ala Phe Phe Gln Ala Thr Asp Leu Pro Tyr Asp 
                165                 170                 175     


Ile Glu Asp Ala Val Met Tyr Trp Ile Asn Lys Val Asn Glu His Leu 
            180                 185                 190         


Lys Asp Ile Met Glu Gln Glu Gln Lys Leu Lys Glu His His Thr Val 
        195                 200                 205             


Glu Ala Pro Gly Gly Gln Lys Ser Pro Ser Lys Trp Phe Trp Lys Leu 
    210                 215                 220                 


Val Pro Ala Arg Tyr Arg Lys Glu Gln Thr Leu Leu Lys Gln Leu Pro 
225                 230                 235                 240 


Cys Ile Pro Leu Val Glu Asn Leu Leu Lys Asp Gly Thr Asp Gly Cys 
                245                 250                 255     


Ala Leu Ala Ala Leu Ile His Phe Tyr Cys Pro Asp Val Val Arg Leu 
            260                 265                 270         


Glu Asp Ile Cys Leu Lys Glu Thr Met Ser Leu Ala Asp Ser Leu Tyr 
        275                 280                 285             


Asn Leu Gln Leu Ile Gln Glu Phe Cys Gln Glu Tyr Leu Asn Gln Cys 
    290                 295                 300                 


Cys His Phe Thr Leu Glu Asp Met Leu Tyr Ala Ala Ser Ser Ile Lys 
305                 310                 315                 320 


Ser Asn Tyr Leu Val Phe Met Ala Glu Leu Phe Trp Trp Phe Glu Val 
                325                 330                 335     


Val Lys Pro Ser Phe Val Gln Pro Arg Val Val Arg Pro Gln Gly Ala 
            340                 345                 350         


Glu Pro Val Lys Asp Met Pro Ser Ile Pro Val Leu Asn Ala Ala Lys 
        355                 360                 365             


Arg Asn Val Leu Asp Ser Ser Ser Asp Phe Pro Ser Ser Gly Glu Gly 
    370                 375                 380                 


Ala Thr Phe Thr Gln Ser His His His Leu Pro Ser Arg Tyr Ser Arg 
385                 390                 395                 400 


Pro Gln Ala His Ser Ser Ala Ser Gly Gly Ile Arg Arg Ser Ser Ser 
                405                 410                 415     


Met Ser Tyr Val Asp Gly Phe Ile Gly Thr Trp Pro Lys Glu Lys Arg 
            420                 425                 430         


Ser Ser Val His Gly Val Ser Phe Asp Ile Ser Phe Asp Lys Glu Asp 
        435                 440                 445             


Ser Val Gln Arg Ser Thr Pro Asn Arg Gly Ile Thr Arg Ser Ile Ser 
    450                 455                 460                 


Asn Glu Gly Leu Thr Leu Asn Asn Ser His Val Ser Lys His Ile Arg 
465                 470                 475                 480 


Lys Asn Leu Ser Phe Lys Pro Ile Asn Gly Glu Glu Glu Ala Glu Ser 
                485                 490                 495     


Ile Glu Glu Glu Leu Asn Ile Asp Ser His Ser Asp Leu Lys Ser Cys 
            500                 505                 510         


Val Pro Leu Asn Thr Asn Glu Leu Asn Ser Asn Glu Asn Ile His Tyr 
        515                 520                 525             


Lys Leu Pro Asn Gly Ala Leu Gln Asn Arg Ile Leu Leu Asp Glu Phe 
    530                 535                 540                 


Gly Asn Gln Ile Glu Thr Pro Ser Ile Glu Glu Ala Leu Gln Ile Ile 
545                 550                 555                 560 


His Asp Thr Glu Lys Ser Pro His Thr Pro Gln Pro Asp Gln Ile Ala 
                565                 570                 575     


Asn Gly Phe Phe Leu His Ser Gln Glu Met Ser Ile Leu Asn Ser Asn 
            580                 585                 590         


Ile Lys Leu Asn Gln Ser Ser Pro Asp Asn Val Thr Asp Thr Lys Gly 
        595                 600                 605             


Ala Leu Ser Pro Ile Thr Asp Asn Thr Glu Val Asp Thr Gly Ile His 
    610                 615                 620                 


Val Pro Ser Glu Asp Ile Pro Glu Thr Met Asp Glu Asp Ser Ser Leu 
625                 630                 635                 640 


Arg Asp Tyr Thr Val Ser Leu Asp Ser Asp Met Asp Asp Ala Ser Lys 
                645                 650                 655     


Phe Leu Gln Asp Tyr Asp Ile Arg Thr Gly Asn Thr Arg Glu Ala Leu 
            660                 665                 670         


Ser Pro Cys Pro Ser Thr Val Ser Thr Lys Ser Gln Pro Gly Ser Ser 
        675                 680                 685             


Ala Ser Ser Ser Ser Gly Val Lys Met Thr Ser Phe Ala Glu Gln Lys 
    690                 695                 700                 


Phe Arg Lys Leu Asn His Thr Asp Gly Lys Ser Ser Gly Ser Ser Ser 
705                 710                 715                 720 


Gln Lys Thr Thr Pro Glu Gly Ser Glu Leu Asn Ile Pro His Val Val 
                725                 730                 735     


Ala Trp Ala Gln Ile Pro Glu Glu Thr Gly Leu Pro Gln Gly Arg Asp 
            740                 745                 750         


Thr Thr Gln Leu Leu Ala Ser Glu Met Val His Leu Arg Met Lys Leu 
        755                 760                 765             


Glu Glu Lys Arg Arg Ala Ile Glu Ala Gln Lys Lys Lys Met Glu Ala 
    770                 775                 780                 


Ala Phe Thr Lys Gln Arg Gln Lys Met Gly Arg Thr Ala Phe Leu Thr 
785                 790                 795                 800 


Val Val Lys Lys Lys Gly Asp Gly Ile Ser Pro Leu Arg Glu Glu Ala 
                805                 810                 815     


Ala Gly Ala Glu Asp Glu Lys Val Tyr Thr Asp Arg Ala Lys Glu Lys 
            820                 825                 830         


Glu Ser Gln Lys Thr Asp Gly Gln Arg Ser Lys Ser Leu Ala Asp Ile 
        835                 840                 845             


Lys Glu Ser Met Glu Asn Pro Gln Ala Lys Trp Leu Lys Ser Pro Thr 
    850                 855                 860                 


Thr Pro Ile Asp Pro Glu Lys Gln Trp Asn Leu Ala Ser Pro Ser Glu 
865                 870                 875                 880 


Glu Thr Leu Asn Glu Gly Glu Ile Leu Glu Tyr Thr Lys Ser Ile Glu 
                885                 890                 895     


Lys Leu Asn Ser Ser Leu His Phe Leu Gln Gln Glu Met Gln Arg Leu 
            900                 905                 910         


Ser Leu Gln Gln Glu Met Leu Met Gln Met Arg Glu Gln Gln Ser Trp 
        915                 920                 925             


Val Ile Ser Pro Pro Gln Pro Ser Pro Gln Lys Gln Ile Arg Asp Phe 
    930                 935                 940                 


Lys Pro Ser Lys Gln Ala Gly Leu Ser Ser Ala Ile Ala Pro Phe Ser 
945                 950                 955                 960 


Ser Asp Ser Pro Arg Pro Thr His Pro Ser Pro Gln Ser Ser Asn Arg 
                965                 970                 975     


Lys Ser Ala Ser Phe Ser Val Lys Ser Gln Arg Thr Pro Arg Pro Asn 
            980                 985                 990         


Glu Leu Lys Ile Thr Pro Leu Asn  Arg Thr Leu Thr Pro  Pro Arg Ser 
        995                 1000                 1005             


Val Asp  Ser Leu Pro Arg Leu  Arg Arg Phe Ser Pro  Ser Gln Val 
    1010                 1015                 1020             


Pro Ile  Gln Thr Arg Ser Phe  Val Cys Phe Gly Asp  Asp Gly Glu 
    1025                 1030                 1035             


Pro Gln  Leu Lys Glu Ser Lys  Pro Lys Glu Glu Val  Lys Lys Glu 
    1040                 1045                 1050             


Glu Leu  Glu Ser Lys Gly Thr  Leu Glu Gln Arg Gly  His Asn Pro 
    1055                 1060                 1065             


Glu Glu  Lys Glu Ile Lys Pro  Phe Glu Ser Thr Val  Ser Glu Val 
    1070                 1075                 1080             


Leu Ser  Leu Pro Val Thr Glu  Thr Val Cys Leu Thr  Pro Asn Glu 
    1085                 1090                 1095             


Asp Gln  Leu Asn Gln Pro Thr  Glu Pro Pro Pro Lys  Pro Val Phe 
    1100                 1105                 1110             


Pro Pro  Thr Ala Pro Lys Asn  Val Asn Leu Ile Glu  Val Ser Leu 
    1115                 1120                 1125             


Ser Asp  Leu Lys Pro Pro Glu  Lys Ala Asp Val Pro  Val Glu Lys 
    1130                 1135                 1140             


Tyr Asp  Gly Glu Ser Asp Lys  Glu Gln Phe Asp Asp  Asp Gln Lys 
    1145                 1150                 1155             


Val Cys  Cys Gly Phe Phe Phe  Lys Asp Asp Gln Lys  Ala Glu Asn 
    1160                 1165                 1170             


Asp Met  Ala Met Lys Arg Ala  Ala Leu Leu Glu Lys  Arg Leu Arg 
    1175                 1180                 1185             


Arg Glu  Lys Glu Thr Gln Leu  Arg Lys Gln Gln Leu  Glu Ala Glu 
    1190                 1195                 1200             


Met Glu  His Lys Lys Glu Glu  Thr Arg Arg Lys Thr  Glu Glu Glu 
    1205                 1210                 1215             


Arg Gln  Lys Lys Glu Asp Glu  Arg Ala Arg Arg Glu  Phe Ile Arg 
    1220                 1225                 1230             


Gln Glu  Tyr Met Arg Arg Lys  Gln Leu Lys Leu Met  Glu Asp Met 
    1235                 1240                 1245             


Asp Thr  Val Ile Lys Pro Arg  Pro Gln Val Val Lys  Gln Lys Lys 
    1250                 1255                 1260             


Gln Arg  Pro Lys Ser Ile His  Arg Asp His Ile Glu  Ser Pro Lys 
    1265                 1270                 1275             


Thr Pro  Ile Lys Gly Pro Pro  Val Ser Ser Leu Ser  Leu Ala Ser 
    1280                 1285                 1290             


Leu Asn  Thr Gly Asp Asn Glu  Ser Val His Ser Gly  Lys Arg Thr 
    1295                 1300                 1305             


Pro Arg  Ser Glu Ser Val Glu  Gly Phe Leu Ser Pro  Ser Arg Cys 
    1310                 1315                 1320             


Gly Ser  Arg Asn Gly Glu Lys  Asp Trp Glu Asn Ala  Ser Thr Thr 
    1325                 1330                 1335             


Ser Ser  Val Ala Ser Gly Thr  Glu Tyr Thr Gly Pro  Lys Leu Tyr 
    1340                 1345                 1350             


Lys Glu  Pro Ser Ala Lys Ser  Asn Lys His Ile Ile  Gln Asn Ala 
    1355                 1360                 1365             


Leu Ala  His Cys Cys Leu Ala  Gly Lys Val Asn Glu  Gly Gln Lys 
    1370                 1375                 1380             


Lys Lys  Ile Leu Glu Glu Met  Glu Lys Ser Asp Ala  Asn Asn Phe 
    1385                 1390                 1395             


Leu Ile  Leu Phe Arg Asp Ser  Gly Cys Gln Phe Arg  Ser Leu Tyr 
    1400                 1405                 1410             


Thr Tyr  Cys Pro Glu Thr Glu  Glu Ile Asn Lys Leu  Thr Gly Ile 
    1415                 1420                 1425             


Gly Pro  Lys Ser Ile Thr Lys  Lys Met Ile Glu Gly  Leu Tyr Lys 
    1430                 1435                 1440             


Tyr Asn  Ser Asp Arg Lys Gln  Phe Ser His Ile Pro  Ala Lys Thr 
    1445                 1450                 1455             


Leu Ser  Ala Ser Val Asp Ala  Ile Thr Ile His Ser  His Leu Trp 
    1460                 1465                 1470             


Gln Thr  Lys Arg Pro Val Thr  Pro Lys Lys Leu Leu  Pro Thr Lys 
    1475                 1480                 1485             


Ala 
    


<210>  1560
<211>  1673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAMTA1__Homo_sapiens__XP_011539388

<400>  1560

Met Trp Arg Ala Glu Gly Lys Trp Leu Pro Lys Thr Ser Arg Lys Ser 
1               5                   10                  15      


Val Ser Gln Ser Val Phe Cys Gly Thr Ser Thr Tyr Cys Val Leu Asn 
            20                  25                  30          


Thr Val Pro Pro Ile Glu Asp Asp His Gly Asn Ser Asn Ser Ser His 
        35                  40                  45              


Val Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Lys Cys 
    50                  55                  60                  


Ser Ser Leu Pro Lys Glu Arg His Arg Trp Asn Thr Asn Glu Glu Ile 
65                  70                  75                  80  


Ala Ala Tyr Leu Ile Thr Phe Glu Lys His Glu Glu Trp Leu Thr Thr 
                85                  90                  95      


Ser Pro Lys Thr Arg Pro Gln Asn Gly Ser Met Ile Leu Tyr Asn Arg 
            100                 105                 110         


Lys Lys Val Lys Tyr Arg Lys Asp Gly Tyr Cys Trp Lys Lys Arg Lys 
        115                 120                 125             


Asp Gly Lys Thr Thr Arg Glu Asp His Met Lys Leu Lys Val Gln Gly 
    130                 135                 140                 


Val Glu Cys Leu Tyr Gly Cys Tyr Val His Ser Ser Ile Ile Pro Thr 
145                 150                 155                 160 


Phe His Arg Arg Cys Tyr Trp Leu Leu Gln Asn Pro Asp Ile Val Leu 
                165                 170                 175     


Val His Tyr Leu Asn Val Pro Ala Ile Glu Asp Cys Gly Lys Pro Cys 
            180                 185                 190         


Gly Pro Ile Leu Cys Ser Ile Asn Thr Asp Lys Lys Glu Trp Ala Lys 
        195                 200                 205             


Trp Thr Lys Glu Glu Leu Ile Gly Gln Leu Lys Pro Met Phe His Gly 
    210                 215                 220                 


Ile Lys Trp Thr Cys Ser Asn Gly Asn Ser Ser Ser Gly Phe Ser Val 
225                 230                 235                 240 


Glu Gln Leu Val Gln Gln Ile Leu Asp Ser His Gln Thr Lys Pro Gln 
                245                 250                 255     


Pro Arg Thr His Asn Cys Leu Cys Thr Gly Ser Leu Gly Ala Gly Gly 
            260                 265                 270         


Ser Val His His Lys Cys Asn Ser Ala Lys His Arg Ile Ile Ser Pro 
        275                 280                 285             


Lys Val Glu Pro Arg Thr Gly Gly Tyr Gly Ser His Ser Glu Val Gln 
    290                 295                 300                 


His Asn Asp Val Ser Glu Gly Lys His Glu His Ser His Ser Lys Gly 
305                 310                 315                 320 


Ser Ser Arg Glu Lys Arg Asn Gly Lys Val Ala Lys Pro Val Leu Leu 
                325                 330                 335     


His Gln Ser Ser Thr Glu Val Ser Ser Thr Asn Gln Val Glu Val Pro 
            340                 345                 350         


Asp Thr Thr Gln Ser Ser Pro Val Ser Ile Ser Ser Gly Leu Asn Ser 
        355                 360                 365             


Asp Pro Asp Met Val Asp Ser Pro Val Val Thr Gly Val Ser Gly Met 
    370                 375                 380                 


Ala Val Ala Ser Val Met Gly Ser Leu Ser Gln Ser Ala Thr Val Phe 
385                 390                 395                 400 


Met Ser Glu Val Thr Asn Glu Ala Val Tyr Thr Met Ser Pro Thr Ala 
                405                 410                 415     


Gly Pro Asn His His Leu Leu Ser Pro Asp Ala Ser Gln Gly Leu Val 
            420                 425                 430         


Leu Ala Val Ser Ser Asp Gly His Lys Phe Ala Phe Pro Thr Thr Gly 
        435                 440                 445             


Ser Ser Glu Ser Leu Ser Met Leu Pro Thr Asn Val Ser Glu Glu Leu 
    450                 455                 460                 


Val Leu Ser Thr Thr Leu Asp Gly Gly Arg Lys Ile Pro Glu Thr Thr 
465                 470                 475                 480 


Met Asn Phe Asp Pro Asp Cys Phe Leu Asn Asn Pro Lys Gln Gly Gln 
                485                 490                 495     


Thr Tyr Gly Gly Gly Gly Leu Lys Ala Glu Met Val Ser Ser Asn Ile 
            500                 505                 510         


Arg His Ser Pro Pro Gly Glu Arg Ser Phe Ser Phe Thr Thr Val Leu 
        515                 520                 525             


Thr Lys Glu Ile Lys Thr Glu Asp Thr Ser Phe Glu Gln Gln Met Ala 
    530                 535                 540                 


Lys Glu Ala Tyr Ser Ser Ser Ala Ala Ala Val Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Thr Leu Thr Ala Gly Ser Ser Leu Leu Pro Ser Gly Gly Gly Leu Ser 
                565                 570                 575     


Pro Ser Thr Thr Leu Glu Gln Met Asp Phe Ser Ala Ile Asp Ser Asn 
            580                 585                 590         


Lys Asp Tyr Thr Ser Ser Phe Ser Gln Thr Gly His Ser Pro His Ile 
        595                 600                 605             


His Gln Thr Pro Ser Pro Ser Phe Phe Leu Gln Asp Ala Ser Lys Pro 
    610                 615                 620                 


Leu Pro Val Glu Gln Asn Thr His Ser Ser Leu Ser Asp Ser Gly Gly 
625                 630                 635                 640 


Thr Phe Val Met Pro Thr Val Lys Thr Glu Ala Ser Ser Gln Thr Ser 
                645                 650                 655     


Ser Cys Ser Gly His Val Glu Thr Arg Ile Glu Ser Thr Ser Ser Leu 
            660                 665                 670         


His Leu Met Gln Phe Gln Ala Asn Phe Gln Ala Met Thr Ala Glu Gly 
        675                 680                 685             


Glu Val Thr Met Glu Thr Ser Gln Ala Ala Glu Gly Ser Glu Val Leu 
    690                 695                 700                 


Leu Lys Ser Gly Glu Leu Gln Ala Cys Ser Ser Glu His Tyr Leu Gln 
705                 710                 715                 720 


Pro Glu Thr Asn Gly Val Ile Arg Ser Ala Gly Gly Val Pro Ile Leu 
                725                 730                 735     


Pro Gly Asn Val Val Gln Gly Leu Tyr Pro Val Ala Gln Pro Ser Leu 
            740                 745                 750         


Gly Asn Ala Ser Asn Met Glu Leu Ser Leu Asp His Phe Asp Ile Ser 
        755                 760                 765             


Phe Ser Asn Gln Phe Ser Asp Leu Ile Asn Asp Phe Ile Ser Val Glu 
    770                 775                 780                 


Gly Gly Ser Ser Thr Ile Tyr Gly His Gln Leu Val Ser Gly Asp Ser 
785                 790                 795                 800 


Thr Ala Leu Ser Gln Ser Glu Asp Gly Ala Arg Ala Pro Phe Thr Gln 
                805                 810                 815     


Ala Glu Met Cys Leu Pro Cys Cys Ser Pro Gln Gln Gly Ser Leu Gln 
            820                 825                 830         


Leu Ser Ser Ser Glu Gly Gly Ala Ser Thr Met Ala Tyr Met His Val 
        835                 840                 845             


Ala Glu Val Val Ser Ala Ala Ser Ala Gln Gly Thr Leu Gly Met Leu 
    850                 855                 860                 


Gln Gln Ser Gly Arg Val Phe Met Val Thr Asp Tyr Ser Pro Glu Trp 
865                 870                 875                 880 


Ser Tyr Pro Glu Gly Gly Val Lys Val Leu Ile Thr Gly Pro Trp Gln 
                885                 890                 895     


Glu Ala Ser Asn Asn Tyr Ser Cys Leu Phe Asp Gln Ile Ser Val Pro 
            900                 905                 910         


Ala Ser Leu Ile Gln Pro Gly Val Leu Arg Cys Tyr Cys Pro Ala His 
        915                 920                 925             


Asp Thr Gly Leu Val Thr Leu Gln Val Ala Phe Asn Asn Gln Ile Ile 
    930                 935                 940                 


Ser Asn Ser Val Val Phe Glu Tyr Lys Ala Arg Ala Leu Pro Thr Leu 
945                 950                 955                 960 


Pro Ser Ser Gln His Asp Trp Leu Ser Leu Asp Asp Asn Gln Phe Arg 
                965                 970                 975     


Met Ser Ile Leu Glu Arg Leu Glu Gln Met Glu Arg Arg Met Ala Glu 
            980                 985                 990         


Met Thr Gly Ser Gln Gln His Lys  Gln Ala Ser Gly Gly  Gly Ser Ser 
        995                 1000                 1005             


Gly Gly  Gly Ser Gly Ser Gly  Asn Gly Gly Ser Gln  Ala Gln Cys 
    1010                 1015                 1020             


Ala Ser  Gly Thr Gly Ala Leu  Gly Ser Cys Phe Glu  Ser Arg Val 
    1025                 1030                 1035             


Val Val  Val Cys Glu Lys Met  Met Ser Arg Ala Cys  Trp Ala Lys 
    1040                 1045                 1050             


Ser Lys  His Leu Ile His Ser  Lys Thr Phe Arg Gly  Met Thr Leu 
    1055                 1060                 1065             


Leu His  Leu Ala Ala Ala Gln  Gly Tyr Ala Thr Leu  Ile Gln Thr 
    1070                 1075                 1080             


Leu Ile  Lys Trp Arg Thr Lys  His Ala Asp Ser Ile  Asp Leu Glu 
    1085                 1090                 1095             


Leu Glu  Val Asp Pro Leu Asn  Val Asp His Phe Ser  Cys Thr Pro 
    1100                 1105                 1110             


Leu Met  Trp Ala Cys Ala Leu  Gly His Leu Glu Ala  Ala Val Val 
    1115                 1120                 1125             


Leu Tyr  Lys Trp Asp Arg Arg  Ala Ile Ser Ile Pro  Asp Ser Leu 
    1130                 1135                 1140             


Gly Arg  Leu Pro Leu Gly Ile  Ala Arg Ser Arg Gly  His Val Lys 
    1145                 1150                 1155             


Leu Ala  Glu Cys Leu Glu His  Leu Gln Arg Asp Glu  Gln Ala Gln 
    1160                 1165                 1170             


Leu Gly  Gln Asn Pro Arg Ile  His Cys Pro Ala Ser  Glu Glu Pro 
    1175                 1180                 1185             


Ser Thr  Glu Ser Trp Met Ala  Gln Trp His Ser Glu  Ala Ile Ser 
    1190                 1195                 1200             


Ser Pro  Glu Ile Pro Lys Gly  Val Thr Val Ile Ala  Ser Thr Asn 
    1205                 1210                 1215             


Pro Glu  Leu Arg Arg Pro Arg  Ser Glu Pro Ser Asn  Tyr Tyr Ser 
    1220                 1225                 1230             


Ser Glu  Ser His Lys Asp Tyr  Pro Ala Pro Lys Lys  His Lys Leu 
    1235                 1240                 1245             


Asn Pro  Glu Tyr Phe Gln Thr  Arg Gln Glu Lys Leu  Leu Pro Thr 
    1250                 1255                 1260             


Ala Leu  Ser Leu Glu Glu Pro  Asn Ile Arg Lys Gln  Ser Pro Ser 
    1265                 1270                 1275             


Ser Lys  Gln Ser Val Pro Glu  Thr Leu Ser Pro Ser  Glu Gly Val 
    1280                 1285                 1290             


Arg Asp  Phe Ser Arg Glu Leu  Ser Pro Pro Thr Pro  Glu Thr Ala 
    1295                 1300                 1305             


Ala Phe  Gln Ala Ser Gly Ser  Gln Pro Val Gly Lys  Trp Asn Ser 
    1310                 1315                 1320             


Lys Asp  Leu Tyr Ile Gly Val  Ser Thr Val Gln Val  Thr Gly Asn 
    1325                 1330                 1335             


Pro Lys  Gly Thr Ser Val Gly  Lys Glu Ala Ala Pro  Ser Gln Val 
    1340                 1345                 1350             


Arg Pro  Arg Glu Pro Met Ser  Val Leu Met Met Ala  Asn Arg Glu 
    1355                 1360                 1365             


Val Val  Asn Thr Glu Leu Gly  Ser Tyr Arg Asp Ser  Ala Glu Asn 
    1370                 1375                 1380             


Glu Glu  Cys Gly Gln Pro Met  Asp Asp Ile Gln Val  Asn Met Met 
    1385                 1390                 1395             


Thr Leu  Ala Glu His Ile Ile  Glu Ala Thr Pro Asp  Arg Ile Lys 
    1400                 1405                 1410             


Gln Glu  Asn Phe Val Pro Met  Glu Ser Ser Gly Leu  Glu Arg Thr 
    1415                 1420                 1425             


Asp Pro  Ala Thr Ile Ser Ser  Thr Met Ser Trp Leu  Ala Ser Tyr 
    1430                 1435                 1440             


Leu Ala  Asp Ala Asp Cys Leu  Pro Ser Ala Ala Gln  Ile Arg Ser 
    1445                 1450                 1455             


Ala Tyr  Asn Glu Pro Leu Thr  Pro Ser Ser Asn Thr  Ser Leu Ser 
    1460                 1465                 1470             


Pro Val  Gly Ser Pro Val Ser  Glu Ile Ala Phe Glu  Lys Pro Asn 
    1475                 1480                 1485             


Leu Pro  Ser Ala Ala Asp Trp  Ser Glu Phe Leu Ser  Ala Ser Thr 
    1490                 1495                 1500             


Ser Glu  Lys Val Glu Asn Glu  Phe Ala Gln Leu Thr  Leu Ser Asp 
    1505                 1510                 1515             


His Glu  Gln Arg Glu Leu Tyr  Glu Ala Ala Arg Leu  Val Gln Thr 
    1520                 1525                 1530             


Ala Phe  Arg Lys Tyr Lys Gly  Arg Pro Leu Arg Glu  Gln Gln Glu 
    1535                 1540                 1545             


Val Ala  Ala Ala Val Ile Gln  Arg Cys Tyr Arg Lys  Tyr Lys Gln 
    1550                 1555                 1560             


Tyr Ala  Leu Tyr Lys Lys Met  Thr Gln Ala Ala Ile  Leu Ile Gln 
    1565                 1570                 1575             


Ser Lys  Phe Arg Ser Tyr Tyr  Glu Gln Lys Lys Phe  Gln Gln Ser 
    1580                 1585                 1590             


Arg Arg  Ala Ala Val Leu Ile  Gln Lys Tyr Tyr Arg  Ser Tyr Lys 
    1595                 1600                 1605             


Lys Cys  Gly Lys Arg Arg Gln  Ala Arg Arg Thr Ala  Val Ile Val 
    1610                 1615                 1620             


Gln Gln  Lys Leu Arg Ser Ser  Leu Leu Thr Lys Lys  Gln Asp Gln 
    1625                 1630                 1635             


Ala Ala  Arg Lys Ile Met Arg  Phe Leu Arg Arg Cys  Arg His Arg 
    1640                 1645                 1650             


Val Lys  Glu Leu Lys Lys Ala  Lys Glu Leu Glu Asp  Ile Gln Gln 
    1655                 1660                 1665             


His Pro  Leu Ala Met 
    1670             


<210>  1561
<211>  1230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAND1__Homo_sapiens__NP_060918

<400>  1561

Met Ala Ser Ala Ser Tyr His Ile Ser Asn Leu Leu Glu Lys Met Thr 
1               5                   10                  15      


Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Asn Asp Leu Met Thr 
            20                  25                  30          


Glu Leu Gln Lys Asp Ser Ile Lys Leu Asp Asp Asp Ser Glu Arg Lys 
        35                  40                  45              


Val Val Lys Met Ile Leu Lys Leu Leu Glu Asp Lys Asn Gly Glu Val 
    50                  55                  60                  


Gln Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Ser Lys Val Lys 
65                  70                  75                  80  


Glu Tyr Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn Met Leu 
                85                  90                  95      


Ser Asp Lys Glu Gln Leu Arg Asp Ile Ser Ser Ile Gly Leu Lys Thr 
            100                 105                 110         


Val Ile Gly Glu Leu Pro Pro Ala Ser Ser Gly Ser Ala Leu Ala Ala 
        115                 120                 125             


Asn Val Cys Lys Lys Ile Thr Gly Arg Leu Thr Ser Ala Ile Ala Lys 
    130                 135                 140                 


Gln Glu Asp Val Ser Val Gln Leu Glu Ala Leu Asp Ile Met Ala Asp 
145                 150                 155                 160 


Met Leu Ser Arg Gln Gly Gly Leu Leu Val Asn Phe His Pro Ser Ile 
                165                 170                 175     


Leu Thr Cys Leu Leu Pro Gln Leu Thr Ser Pro Arg Leu Ala Val Arg 
            180                 185                 190         


Lys Arg Thr Ile Ile Ala Leu Gly His Leu Val Met Ser Cys Gly Asn 
        195                 200                 205             


Ile Val Phe Val Asp Leu Ile Glu His Leu Leu Ser Glu Leu Ser Lys 
    210                 215                 220                 


Asn Asp Ser Met Ser Thr Thr Arg Thr Tyr Ile Gln Cys Ile Ala Ala 
225                 230                 235                 240 


Ile Ser Arg Gln Ala Gly His Arg Ile Gly Glu Tyr Leu Glu Lys Ile 
                245                 250                 255     


Ile Pro Leu Val Val Lys Phe Cys Asn Val Asp Asp Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr Cys Ile Gln Ala Phe Glu Ser Phe Val Arg Arg Cys Pro Lys 
        275                 280                 285             


Glu Val Tyr Pro His Val Ser Thr Ile Ile Asn Ile Cys Leu Lys Tyr 
    290                 295                 300                 


Leu Thr Tyr Asp Pro Asn Tyr Asn Tyr Asp Asp Glu Asp Glu Asp Glu 
305                 310                 315                 320 


Asn Ala Met Asp Ala Asp Gly Gly Asp Asp Asp Asp Gln Gly Ser Asp 
                325                 330                 335     


Asp Glu Tyr Ser Asp Asp Asp Asp Met Ser Trp Lys Val Arg Arg Ala 
            340                 345                 350         


Ala Ala Lys Cys Leu Asp Ala Val Val Ser Thr Arg His Glu Met Leu 
        355                 360                 365             


Pro Glu Phe Tyr Lys Thr Val Ser Pro Ala Leu Ile Ser Arg Phe Lys 
    370                 375                 380                 


Glu Arg Glu Glu Asn Val Lys Ala Asp Val Phe His Ala Tyr Leu Ser 
385                 390                 395                 400 


Leu Leu Lys Gln Thr Arg Pro Val Gln Ser Trp Leu Cys Asp Pro Asp 
                405                 410                 415     


Ala Met Glu Gln Gly Glu Thr Pro Leu Thr Met Leu Gln Ser Gln Val 
            420                 425                 430         


Pro Asn Ile Val Lys Ala Leu His Lys Gln Met Lys Glu Lys Ser Val 
        435                 440                 445             


Lys Thr Arg Gln Cys Cys Phe Asn Met Leu Thr Glu Leu Val Asn Val 
    450                 455                 460                 


Leu Pro Gly Ala Leu Thr Gln His Ile Pro Val Leu Val Pro Gly Ile 
465                 470                 475                 480 


Ile Phe Ser Leu Asn Asp Lys Ser Ser Ser Ser Asn Leu Lys Ile Asp 
                485                 490                 495     


Ala Leu Ser Cys Leu Tyr Val Ile Leu Cys Asn His Ser Pro Gln Val 
            500                 505                 510         


Phe His Pro His Val Gln Ala Leu Val Pro Pro Val Val Ala Cys Val 
        515                 520                 525             


Gly Asp Pro Phe Tyr Lys Ile Thr Ser Glu Ala Leu Leu Val Thr Gln 
    530                 535                 540                 


Gln Leu Val Lys Val Ile Arg Pro Leu Asp Gln Pro Ser Ser Phe Asp 
545                 550                 555                 560 


Ala Thr Pro Tyr Ile Lys Asp Leu Phe Thr Cys Thr Ile Lys Arg Leu 
                565                 570                 575     


Lys Ala Ala Asp Ile Asp Gln Glu Val Lys Glu Arg Ala Ile Ser Cys 
            580                 585                 590         


Met Gly Gln Ile Ile Cys Asn Leu Gly Asp Asn Leu Gly Ser Asp Leu 
        595                 600                 605             


Pro Asn Thr Leu Gln Ile Phe Leu Glu Arg Leu Lys Asn Glu Ile Thr 
    610                 615                 620                 


Arg Leu Thr Thr Val Lys Ala Leu Thr Leu Ile Ala Gly Ser Pro Leu 
625                 630                 635                 640 


Lys Ile Asp Leu Arg Pro Val Leu Gly Glu Gly Val Pro Ile Leu Ala 
                645                 650                 655     


Ser Phe Leu Arg Lys Asn Gln Arg Ala Leu Lys Leu Gly Thr Leu Ser 
            660                 665                 670         


Ala Leu Asp Ile Leu Ile Lys Asn Tyr Ser Asp Ser Leu Thr Ala Ala 
        675                 680                 685             


Met Ile Asp Ala Val Leu Asp Glu Leu Pro Pro Leu Ile Ser Glu Ser 
    690                 695                 700                 


Asp Met His Val Ser Gln Met Ala Ile Ser Phe Leu Thr Thr Leu Ala 
705                 710                 715                 720 


Lys Val Tyr Pro Ser Ser Leu Ser Lys Ile Ser Gly Ser Ile Leu Asn 
                725                 730                 735     


Glu Leu Ile Gly Leu Val Arg Ser Pro Leu Leu Gln Gly Gly Ala Leu 
            740                 745                 750         


Ser Ala Met Leu Asp Phe Phe Gln Ala Leu Val Val Thr Gly Thr Asn 
        755                 760                 765             


Asn Leu Gly Tyr Met Asp Leu Leu Arg Met Leu Thr Gly Pro Val Tyr 
    770                 775                 780                 


Ser Gln Ser Thr Ala Leu Thr His Lys Gln Ser Tyr Tyr Ser Ile Ala 
785                 790                 795                 800 


Lys Cys Val Ala Ala Leu Thr Arg Ala Cys Pro Lys Glu Gly Pro Ala 
                805                 810                 815     


Val Val Gly Gln Phe Ile Gln Asp Val Lys Asn Ser Arg Ser Thr Asp 
            820                 825                 830         


Ser Ile Arg Leu Leu Ala Leu Leu Ser Leu Gly Glu Val Gly His His 
        835                 840                 845             


Ile Asp Leu Ser Gly Gln Leu Glu Leu Lys Ser Val Ile Leu Glu Ala 
    850                 855                 860                 


Phe Ser Ser Pro Ser Glu Glu Val Lys Ser Ala Ala Ser Tyr Ala Leu 
865                 870                 875                 880 


Gly Ser Ile Ser Val Gly Asn Leu Pro Glu Tyr Leu Pro Phe Val Leu 
                885                 890                 895     


Gln Glu Ile Thr Ser Gln Pro Lys Arg Gln Tyr Leu Leu Leu His Ser 
            900                 905                 910         


Leu Lys Glu Ile Ile Ser Ser Ala Ser Val Val Gly Leu Lys Pro Tyr 
        915                 920                 925             


Val Glu Asn Ile Trp Ala Leu Leu Leu Lys His Cys Glu Cys Ala Glu 
    930                 935                 940                 


Glu Gly Thr Arg Asn Val Val Ala Glu Cys Leu Gly Lys Leu Thr Leu 
945                 950                 955                 960 


Ile Asp Pro Glu Thr Leu Leu Pro Arg Leu Lys Gly Tyr Leu Ile Ser 
                965                 970                 975     


Gly Ser Ser Tyr Ala Arg Ser Ser Val Val Thr Ala Val Lys Phe Thr 
            980                 985                 990         


Ile Ser Asp His Pro Gln Pro Ile  Asp Pro Leu Leu Lys  Asn Cys Ile 
        995                 1000                 1005             


Gly Asp  Phe Leu Lys Thr Leu  Glu Asp Pro Asp Leu  Asn Val Arg 
    1010                 1015                 1020             


Arg Val  Ala Leu Val Thr Phe  Asn Ser Ala Ala His  Asn Lys Pro 
    1025                 1030                 1035             


Ser Leu  Ile Arg Asp Leu Leu  Asp Thr Val Leu Pro  His Leu Tyr 
    1040                 1045                 1050             


Asn Glu  Thr Lys Val Arg Lys  Glu Leu Ile Arg Glu  Val Glu Met 
    1055                 1060                 1065             


Gly Pro  Phe Lys His Thr Val  Asp Asp Gly Leu Asp  Ile Arg Lys 
    1070                 1075                 1080             


Ala Ala  Phe Glu Cys Met Tyr  Thr Leu Leu Asp Ser  Cys Leu Asp 
    1085                 1090                 1095             


Arg Leu  Asp Ile Phe Glu Phe  Leu Asn His Val Glu  Asp Gly Leu 
    1100                 1105                 1110             


Lys Asp  His Tyr Asp Ile Lys  Met Leu Thr Phe Leu  Met Leu Val 
    1115                 1120                 1125             


Arg Leu  Ser Thr Leu Cys Pro  Ser Ala Val Leu Gln  Arg Leu Asp 
    1130                 1135                 1140             


Arg Leu  Val Glu Pro Leu Arg  Ala Thr Cys Thr Thr  Lys Val Lys 
    1145                 1150                 1155             


Ala Asn  Ser Val Lys Gln Glu  Phe Glu Lys Gln Asp  Glu Leu Lys 
    1160                 1165                 1170             


Arg Ser  Ala Met Arg Ala Val  Ala Ala Leu Leu Thr  Ile Pro Glu 
    1175                 1180                 1185             


Ala Glu  Lys Ser Pro Leu Met  Ser Glu Phe Gln Ser  Gln Ile Ser 
    1190                 1195                 1200             


Ser Asn  Pro Glu Leu Ala Ala  Ile Phe Glu Ser Ile  Gln Lys Asp 
    1205                 1210                 1215             


Ser Ser  Ser Thr Asn Leu Glu  Ser Met Asp Thr Ser  
    1220                 1225                 1230 


<210>  1562
<211>  1236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAND2__Homo_sapiens__NP_001155971

<400>  1562

Met Ser Thr Ala Ala Phe His Ile Ser Ser Leu Leu Glu Lys Met Thr 
1               5                   10                  15      


Ser Ser Asp Lys Asp Phe Arg Phe Met Ala Thr Ser Asp Leu Met Ser 
            20                  25                  30          


Glu Leu Gln Lys Asp Ser Ile Gln Leu Asp Glu Asp Ser Glu Arg Lys 
        35                  40                  45              


Val Val Lys Met Leu Leu Arg Leu Leu Glu Asp Lys Asn Gly Glu Val 
    50                  55                  60                  


Gln Asn Leu Ala Val Lys Cys Leu Gly Pro Leu Val Val Lys Val Lys 
65                  70                  75                  80  


Glu Tyr Gln Val Glu Thr Ile Val Asp Thr Leu Cys Thr Asn Met Arg 
                85                  90                  95      


Ser Asp Lys Glu Gln Leu Arg Asp Ile Ala Gly Ile Gly Leu Lys Thr 
            100                 105                 110         


Val Leu Ser Glu Leu Pro Pro Ala Ala Thr Gly Ser Gly Leu Ala Thr 
        115                 120                 125             


Asn Val Cys Arg Lys Ile Thr Gly Gln Leu Thr Ser Ala Ile Ala Gln 
    130                 135                 140                 


Gln Glu Asp Val Ala Val Gln Leu Glu Ala Leu Asp Ile Leu Ser Asp 
145                 150                 155                 160 


Met Leu Ser Arg Leu Gly Val Pro Leu Gly Ala Phe His Ala Ser Leu 
                165                 170                 175     


Leu His Cys Leu Leu Pro Gln Leu Ser Ser Pro Arg Leu Ala Val Arg 
            180                 185                 190         


Lys Arg Ala Val Gly Ala Leu Gly His Leu Ala Ala Ala Cys Ser Thr 
        195                 200                 205             


Asp Leu Phe Val Glu Leu Ala Asp His Leu Leu Asp Arg Leu Pro Gly 
    210                 215                 220                 


Pro Arg Val Pro Thr Ser Pro Thr Ala Ile Arg Thr Leu Ile Gln Cys 
225                 230                 235                 240 


Leu Gly Ser Val Gly Arg Gln Ala Gly His Arg Leu Gly Ala His Leu 
                245                 250                 255     


Asp Arg Leu Val Pro Leu Val Glu Asp Phe Cys Asn Leu Asp Asp Asp 
            260                 265                 270         


Glu Leu Arg Glu Ser Cys Leu Gln Ala Phe Glu Ala Phe Leu Arg Lys 
        275                 280                 285             


Cys Pro Lys Glu Met Gly Pro His Val Pro Asn Val Thr Ser Leu Cys 
    290                 295                 300                 


Leu Gln Tyr Ile Lys His Asp Pro Asn Tyr Asn Tyr Asp Ser Asp Glu 
305                 310                 315                 320 


Asp Glu Glu Gln Met Glu Thr Glu Asp Ser Glu Phe Ser Glu Gln Glu 
                325                 330                 335     


Ser Glu Asp Glu Tyr Ser Asp Asp Asp Asp Met Ser Trp Lys Val Arg 
            340                 345                 350         


Arg Ala Ala Ala Lys Cys Ile Ala Ala Leu Ile Ser Ser Arg Pro Asp 
        355                 360                 365             


Leu Leu Pro Asp Phe His Cys Thr Leu Ala Pro Val Leu Ile Arg Arg 
    370                 375                 380                 


Phe Lys Glu Arg Glu Glu Asn Val Lys Ala Asp Val Phe Thr Ala Tyr 
385                 390                 395                 400 


Ile Val Leu Leu Arg Gln Thr Gln Pro Pro Lys Gly Trp Leu Glu Ala 
                405                 410                 415     


Met Glu Glu Pro Thr Gln Thr Gly Ser Asn Leu His Met Leu Arg Gly 
            420                 425                 430         


Gln Val Pro Leu Val Val Lys Ala Leu Gln Arg Gln Leu Lys Asp Arg 
        435                 440                 445             


Ser Val Arg Ala Arg Gln Gly Cys Phe Ser Leu Leu Thr Glu Leu Ala 
    450                 455                 460                 


Gly Val Leu Pro Gly Ser Leu Ala Glu His Met Pro Val Leu Val Ser 
465                 470                 475                 480 


Gly Ile Ile Phe Ser Leu Ala Asp Arg Ser Ser Ser Ser Thr Ile Arg 
                485                 490                 495     


Met Asp Ala Leu Ala Phe Leu Gln Gly Leu Leu Gly Thr Glu Pro Ala 
            500                 505                 510         


Glu Ala Phe His Pro His Leu Pro Ile Leu Leu Pro Pro Val Met Ala 
        515                 520                 525             


Cys Val Ala Asp Ser Phe Tyr Lys Ile Ala Ala Glu Ala Leu Val Val 
    530                 535                 540                 


Leu Gln Glu Leu Val Arg Ala Leu Trp Pro Leu His Arg Pro Arg Met 
545                 550                 555                 560 


Leu Asp Pro Glu Pro Tyr Val Gly Glu Met Ser Ala Val Thr Leu Ala 
                565                 570                 575     


Arg Leu Arg Ala Thr Asp Leu Asp Gln Glu Val Lys Glu Arg Ala Ile 
            580                 585                 590         


Ser Cys Met Gly His Leu Val Gly His Leu Gly Asp Arg Leu Gly Asp 
        595                 600                 605             


Asp Leu Glu Pro Thr Leu Leu Leu Leu Leu Asp Arg Leu Arg Asn Glu 
    610                 615                 620                 


Ile Thr Arg Leu Pro Ala Ile Lys Ala Leu Thr Leu Val Ala Val Ser 
625                 630                 635                 640 


Pro Leu Gln Leu Asp Leu Gln Pro Ile Leu Ala Glu Ala Leu His Ile 
                645                 650                 655     


Leu Ala Ser Phe Leu Arg Lys Asn Gln Arg Ala Leu Arg Leu Ala Thr 
            660                 665                 670         


Leu Ala Ala Leu Asp Ala Leu Ala Gln Ser Gln Gly Leu Ser Leu Pro 
        675                 680                 685             


Pro Ser Ala Val Gln Ala Val Leu Ala Glu Leu Pro Ala Leu Val Asn 
    690                 695                 700                 


Glu Ser Asp Met His Val Ala Gln Leu Ala Val Asp Phe Leu Ala Thr 
705                 710                 715                 720 


Val Thr Gln Ala Gln Pro Ala Ser Leu Val Glu Val Ser Gly Pro Val 
                725                 730                 735     


Leu Ser Glu Leu Leu Arg Leu Leu Arg Ser Pro Leu Leu Pro Ala Gly 
            740                 745                 750         


Val Leu Ala Ala Ala Glu Gly Phe Leu Gln Ala Leu Val Gly Thr Arg 
        755                 760                 765             


Pro Pro Cys Val Asp Tyr Ala Lys Leu Ile Ser Leu Leu Thr Ala Pro 
    770                 775                 780                 


Val Tyr Glu Gln Ala Val Asp Gly Gly Pro Gly Leu His Lys Gln Val 
785                 790                 795                 800 


Phe His Ser Leu Ala Arg Cys Val Ala Ala Leu Ser Ala Ala Cys Pro 
                805                 810                 815     


Gln Glu Ala Ala Ser Thr Ala Ser Arg Leu Val Cys Asp Ala Arg Ser 
            820                 825                 830         


Pro His Ser Ser Thr Gly Val Lys Val Leu Ala Phe Leu Ser Leu Ala 
        835                 840                 845             


Glu Val Gly Gln Val Ala Gly Pro Gly His Gln Arg Glu Leu Lys Ala 
    850                 855                 860                 


Val Leu Leu Glu Ala Leu Gly Ser Pro Ser Glu Asp Val Arg Ala Ala 
865                 870                 875                 880 


Ala Ser Tyr Ala Leu Gly Arg Val Gly Ala Gly Ser Leu Pro Asp Phe 
                885                 890                 895     


Leu Pro Phe Leu Leu Glu Gln Ile Glu Ala Glu Pro Arg Arg Gln Tyr 
            900                 905                 910         


Leu Leu Leu His Ser Leu Arg Glu Ala Leu Gly Ala Ala Gln Pro Asp 
        915                 920                 925             


Ser Leu Lys Pro Tyr Ala Glu Asp Ile Trp Ala Leu Leu Phe Gln Arg 
    930                 935                 940                 


Cys Glu Gly Ala Glu Glu Gly Thr Arg Gly Val Val Ala Glu Cys Ile 
945                 950                 955                 960 


Gly Lys Leu Val Leu Val Asn Pro Ser Phe Leu Leu Pro Arg Leu Arg 
                965                 970                 975     


Lys Gln Leu Ala Ala Gly Arg Pro His Thr Arg Ser Thr Val Ile Thr 
            980                 985                 990         


Ala Val Lys Phe Leu Ile Ser Asp  Gln Pro His Pro Ile  Asp Pro Leu 
        995                 1000                 1005             


Leu Lys  Ser Phe Ile Gly Glu  Phe Met Glu Ser Leu  Gln Asp Pro 
    1010                 1015                 1020             


Asp Leu  Asn Val Arg Arg Ala  Thr Leu Ala Phe Phe  Asn Ser Ala 
    1025                 1030                 1035             


Val His  Asn Lys Pro Ser Leu  Val Arg Asp Leu Leu  Asp Asp Ile 
    1040                 1045                 1050             


Leu Pro  Leu Leu Tyr Gln Glu  Thr Lys Ile Arg Arg  Asp Leu Ile 
    1055                 1060                 1065             


Arg Glu  Val Glu Met Gly Pro  Phe Lys His Thr Val  Asp Asp Gly 
    1070                 1075                 1080             


Leu Asp  Val Arg Lys Ala Ala  Phe Glu Cys Met Tyr  Ser Leu Leu 
    1085                 1090                 1095             


Glu Ser  Cys Leu Gly Gln Leu  Asp Ile Cys Glu Phe  Leu Asn His 
    1100                 1105                 1110             


Val Glu  Asp Gly Leu Lys Asp  His Tyr Asp Ile Arg  Met Leu Thr 
    1115                 1120                 1125             


Phe Ile  Met Val Ala Arg Leu  Ala Thr Leu Cys Pro  Ala Pro Val 
    1130                 1135                 1140             


Leu Gln  Arg Val Asp Arg Leu  Ile Glu Pro Leu Arg  Ala Thr Cys 
    1145                 1150                 1155             


Thr Ala  Lys Val Lys Ala Gly  Ser Val Lys Gln Glu  Phe Glu Lys 
    1160                 1165                 1170             


Gln Asp  Glu Leu Lys Arg Ser  Ala Met Arg Ala Val  Ala Ala Leu 
    1175                 1180                 1185             


Leu Thr  Ile Pro Glu Val Gly  Lys Ser Pro Ile Met  Ala Asp Phe 
    1190                 1195                 1200             


Ser Ser  Gln Ile Arg Ser Asn  Pro Glu Leu Ala Ala  Leu Phe Glu 
    1205                 1210                 1215             


Ser Ile  Gln Lys Asp Ser Ala  Ser Ala Pro Ser Thr  Asp Ser Met 
    1220                 1225                 1230             


Glu Leu  Ser 
    1235     


<210>  1563
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CANT1__Homo_sapiens__XP_005257079

<400>  1563

Met Pro Val Gln Leu Ser Glu His Pro Glu Trp Asn Glu Ser Met His 
1               5                   10                  15      


Ser Leu Arg Ile Ser Val Gly Gly Leu Pro Val Leu Ala Ser Met Thr 
            20                  25                  30          


Lys Ala Ala Asp Pro Arg Phe Arg Pro Arg Trp Lys Val Ile Leu Thr 
        35                  40                  45              


Phe Phe Val Gly Ala Ala Ile Leu Trp Leu Leu Cys Ser His Arg Pro 
    50                  55                  60                  


Ala Pro Gly Arg Pro Pro Thr His Asn Ala His Asn Trp Arg Leu Gly 
65                  70                  75                  80  


Gln Ala Pro Ala Asn Trp Tyr Asn Asp Thr Tyr Pro Leu Ser Pro Pro 
                85                  90                  95      


Gln Arg Thr Pro Ala Gly Ile Arg Tyr Arg Ile Ala Val Ile Ala Asp 
            100                 105                 110         


Leu Asp Thr Glu Ser Arg Ala Gln Glu Glu Asn Thr Trp Phe Ser Tyr 
        115                 120                 125             


Leu Lys Lys Gly Tyr Leu Thr Leu Ser Asp Ser Gly Asp Lys Val Ala 
    130                 135                 140                 


Val Glu Trp Asp Lys Asp His Gly Val Leu Glu Ser His Leu Ala Glu 
145                 150                 155                 160 


Lys Gly Arg Gly Met Glu Leu Ser Asp Leu Ile Val Phe Asn Gly Lys 
                165                 170                 175     


Leu Tyr Ser Val Asp Asp Arg Thr Gly Val Val Tyr Gln Ile Glu Gly 
            180                 185                 190         


Ser Lys Ala Val Pro Trp Val Ile Leu Ser Asp Gly Asp Gly Thr Val 
        195                 200                 205             


Glu Lys Gly Phe Lys Ala Glu Trp Leu Ala Val Lys Asp Glu Arg Leu 
    210                 215                 220                 


Tyr Val Gly Gly Leu Gly Lys Glu Trp Thr Thr Thr Thr Gly Asp Val 
225                 230                 235                 240 


Val Asn Glu Asn Pro Glu Trp Val Lys Val Val Gly Tyr Lys Gly Ser 
                245                 250                 255     


Val Asp His Glu Asn Trp Val Ser Asn Tyr Asn Ala Leu Arg Ala Ala 
            260                 265                 270         


Ala Gly Ile Gln Pro Pro Gly Tyr Leu Ile His Glu Ser Ala Cys Trp 
        275                 280                 285             


Ser Asp Thr Leu Gln Arg Trp Phe Phe Leu Pro Arg Arg Ala Ser Gln 
    290                 295                 300                 


Glu Arg Tyr Ser Glu Lys Asp Asp Glu Arg Lys Gly Ala Asn Leu Leu 
305                 310                 315                 320 


Leu Ser Ala Ser Pro Asp Phe Gly Asp Ile Ala Val Ser His Val Gly 
                325                 330                 335     


Ala Val Val Pro Thr His Gly Phe Ser Ser Phe Lys Phe Ile Pro Asn 
            340                 345                 350         


Thr Asp Asp Gln Ile Ile Val Ala Leu Lys Ser Glu Glu Asp Ser Gly 
        355                 360                 365             


Arg Val Ala Ser Tyr Ile Met Ala Phe Thr Leu Asp Gly Arg Phe Leu 
    370                 375                 380                 


Leu Pro Glu Thr Lys Ile Gly Ser Val Lys Tyr Glu Gly Ile Glu Phe 
385                 390                 395                 400 


Ile 
    


<210>  1564
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CANX__Homo_sapiens__XP_011532966

<400>  1564

Met Tyr Gln Lys Glu Asn Thr Gln Trp Leu Arg Asn Leu Ala Val Thr 
1               5                   10                  15      


Ala Pro Ile Leu Glu Ala Ser Asn Pro Val Gly Glu Gly Gln Gly Val 
            20                  25                  30          


Lys Ser Arg Lys Ala Pro Glu Ser Ser Ser Lys Cys Ile Ser Phe His 
        35                  40                  45              


Thr Gly Gly Leu Glu Ile Met Glu Gly Lys Trp Leu Leu Cys Met Leu 
    50                  55                  60                  


Leu Val Leu Gly Thr Ala Ile Val Glu Ala His Asp Gly His Asp Asp 
65                  70                  75                  80  


Asp Val Ile Asp Ile Glu Asp Asp Leu Asp Asp Val Ile Glu Glu Val 
                85                  90                  95      


Glu Asp Ser Lys Pro Asp Thr Thr Ala Pro Pro Ser Ser Pro Lys Val 
            100                 105                 110         


Thr Tyr Lys Ala Pro Val Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser 
        115                 120                 125             


Phe Asp Arg Gly Thr Leu Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys 
    130                 135                 140                 


Asp Asp Thr Asp Asp Glu Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val 
145                 150                 155                 160 


Glu Glu Met Lys Glu Ser Lys Leu Pro Gly Asp Lys Gly Leu Val Leu 
                165                 170                 175     


Met Ser Arg Ala Lys His His Ala Ile Ser Ala Lys Leu Asn Lys Pro 
            180                 185                 190         


Phe Leu Phe Asp Thr Lys Pro Leu Ile Val Gln Tyr Glu Val Asn Phe 
        195                 200                 205             


Gln Asn Gly Ile Glu Cys Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys 
    210                 215                 220                 


Thr Pro Glu Leu Asn Leu Asp Gln Phe His Asp Lys Thr Pro Tyr Thr 
225                 230                 235                 240 


Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His Phe 
                245                 250                 255     


Ile Phe Arg His Lys Asn Pro Lys Thr Gly Ile Tyr Glu Glu Lys His 
            260                 265                 270         


Ala Lys Arg Pro Asp Ala Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys 
        275                 280                 285             


Thr His Leu Tyr Thr Leu Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile 
    290                 295                 300                 


Leu Val Asp Gln Ser Val Val Asn Ser Gly Asn Leu Leu Asn Asp Met 
305                 310                 315                 320 


Thr Pro Pro Val Asn Pro Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg 
                325                 330                 335     


Lys Pro Glu Asp Trp Asp Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala 
            340                 345                 350         


Val Lys Pro Asp Asp Trp Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp 
        355                 360                 365             


Glu Glu Ala Thr Lys Pro Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr 
    370                 375                 380                 


Val Pro Asp Pro Asp Ala Glu Lys Pro Glu Asp Trp Asp Glu Asp Met 
385                 390                 395                 400 


Asp Gly Glu Trp Glu Ala Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser 
                405                 410                 415     


Ala Pro Gly Cys Gly Val Trp Gln Arg Pro Val Ile Asp Asn Pro Asn 
            420                 425                 430         


Tyr Lys Gly Lys Trp Lys Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln 
        435                 440                 445             


Gly Ile Trp Lys Pro Arg Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp 
    450                 455                 460                 


Leu Glu Pro Phe Arg Met Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu 
465                 470                 475                 480 


Trp Ser Met Thr Ser Asp Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala 
                485                 490                 495     


Asp Arg Arg Ile Val Asp Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys 
            500                 505                 510         


Lys Ala Ala Asp Gly Ala Ala Glu Pro Gly Val Val Gly Gln Met Ile 
        515                 520                 525             


Glu Ala Ala Glu Glu Arg Pro Trp Leu Trp Val Val Tyr Ile Leu Thr 
    530                 535                 540                 


Val Ala Leu Pro Val Phe Leu Val Ile Leu Phe Cys Cys Ser Gly Lys 
545                 550                 555                 560 


Lys Gln Thr Ser Gly Met Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro 
                565                 570                 575     


Asp Val Lys Glu Glu Glu Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly 
            580                 585                 590         


Asp Glu Glu Glu Glu Gly Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser 
        595                 600                 605             


Asp Ala Glu Glu Asp Gly Gly Thr Val Ser Gln Glu Glu Glu Asp Arg 
    610                 615                 620                 


Lys Pro Lys Ala Glu Glu Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn 
625                 630                 635                 640 


Arg Lys Pro Arg Arg Glu 
                645     


<210>  1565
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAP1__Homo_sapiens__XP_011538812

<400>  1565

Met Ala Asp Met Gln Asn Leu Val Glu Arg Leu Glu Arg Ala Val Gly 
1               5                   10                  15      


Arg Leu Glu Ala Val Ser His Thr Ser Asp Met His Arg Gly Tyr Ala 
            20                  25                  30          


Asp Ser Pro Ser Lys Ala Gly Ala Ala Pro Tyr Val Gln Ala Phe Asp 
        35                  40                  45              


Ser Leu Leu Ala Gly Pro Val Ala Glu Tyr Leu Lys Ile Ser Lys Glu 
    50                  55                  60                  


Ile Gly Gly Asp Val Gln Lys His Ala Glu Met Val His Thr Gly Leu 
65                  70                  75                  80  


Lys Leu Glu Arg Ala Leu Leu Val Thr Ala Ser Gln Cys Gln Gln Pro 
                85                  90                  95      


Ala Glu Asn Lys Leu Ser Asp Leu Leu Ala Pro Ile Ser Glu Gln Ile 
            100                 105                 110         


Lys Glu Val Ile Thr Phe Arg Glu Lys Asn Arg Gly Ser Lys Leu Phe 
        115                 120                 125             


Asn His Leu Ser Ala Val Ser Glu Ser Ile Gln Ala Leu Gly Trp Val 
    130                 135                 140                 


Ala Met Ala Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn Asp Ala 
145                 150                 155                 160 


Ala Met Phe Tyr Thr Asn Arg Val Leu Lys Glu Tyr Lys Asp Val Asp 
                165                 170                 175     


Lys Lys His Val Asp Trp Val Lys Ala Tyr Leu Ser Ile Trp Thr Glu 
            180                 185                 190         


Leu Gln Ala Tyr Ile Lys Glu Phe His Thr Thr Gly Leu Ala Trp Ser 
        195                 200                 205             


Lys Thr Gly Pro Val Ala Lys Glu Leu Ser Gly Leu Pro Ser Gly Pro 
    210                 215                 220                 


Ser Ala Gly Ser Cys Pro Pro Pro Pro Pro Pro Cys Pro Pro Pro Pro 
225                 230                 235                 240 


Pro Val Ser Thr Ile Ser Cys Ser Tyr Glu Ser Ala Ser Arg Ser Ser 
                245                 250                 255     


Leu Phe Ala Gln Ile Asn Gln Gly Glu Ser Ile Thr His Ala Leu Lys 
            260                 265                 270         


His Val Ser Asp Asp Met Lys Thr His Lys Asn Pro Ala Leu Lys Ala 
        275                 280                 285             


Gln Ser Gly Pro Val Arg Ser Gly Pro Lys Pro Phe Ser Ala Pro Lys 
    290                 295                 300                 


Pro Gln Thr Ser Pro Ser Pro Lys Arg Ala Thr Lys Lys Glu Pro Ala 
305                 310                 315                 320 


Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Asn Gln Glu Asn 
                325                 330                 335     


Val Ser Asn Leu Val Ile Glu Asp Thr Glu Leu Lys Gln Val Ala Tyr 
            340                 345                 350         


Ile Tyr Lys Cys Val Asn Thr Thr Leu Gln Ile Lys Gly Lys Ile Asn 
        355                 360                 365             


Ser Ile Thr Val Asp Asn Cys Lys Lys Leu Gly Leu Val Phe Asp Asp 
    370                 375                 380                 


Val Val Gly Ile Val Glu Ile Ile Asn Ser Lys Asp Val Lys Val Gln 
385                 390                 395                 400 


Val Met Gly Lys Val Pro Thr Ile Ser Ile Asn Lys Thr Asp Gly Cys 
                405                 410                 415     


His Ala Tyr Leu Ser Lys Asn Ser Leu Asp Cys Glu Ile Val Ser Ala 
            420                 425                 430         


Lys Ser Ser Glu Met Asn Val Leu Ile Pro Thr Glu Gly Gly Asp Phe 
        435                 440                 445             


Asn Glu Phe Pro Val Pro Glu Gln Phe Lys Thr Leu Trp Asn Gly Gln 
    450                 455                 460                 


Lys Leu Val Thr Thr Val Thr Glu Ile Ala Gly 
465                 470                 475 


<210>  1566
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAP2__Homo_sapiens__NP_006357

<400>  1566

Met Ala Asn Met Gln Gly Leu Val Glu Arg Leu Glu Arg Ala Val Ser 
1               5                   10                  15      


Arg Leu Glu Ser Leu Ser Ala Glu Ser His Arg Pro Pro Gly Asn Cys 
            20                  25                  30          


Gly Glu Val Asn Gly Val Ile Ala Gly Val Ala Pro Ser Val Glu Ala 
        35                  40                  45              


Phe Asp Lys Leu Met Asp Ser Met Val Ala Glu Phe Leu Lys Asn Ser 
    50                  55                  60                  


Arg Ile Leu Ala Gly Asp Val Glu Thr His Ala Glu Met Val His Ser 
65                  70                  75                  80  


Ala Phe Gln Ala Gln Arg Ala Phe Leu Leu Met Ala Ser Gln Tyr Gln 
                85                  90                  95      


Gln Pro His Glu Asn Asp Val Ala Ala Leu Leu Lys Pro Ile Ser Glu 
            100                 105                 110         


Lys Ile Gln Glu Ile Gln Thr Phe Arg Glu Arg Asn Arg Gly Ser Asn 
        115                 120                 125             


Met Phe Asn His Leu Ser Ala Val Ser Glu Ser Ile Pro Ala Leu Gly 
    130                 135                 140                 


Trp Ile Ala Val Ser Pro Lys Pro Gly Pro Tyr Val Lys Glu Met Asn 
145                 150                 155                 160 


Asp Ala Ala Thr Phe Tyr Thr Asn Arg Val Leu Lys Asp Tyr Lys His 
                165                 170                 175     


Ser Asp Leu Arg His Val Asp Trp Val Lys Ser Tyr Leu Asn Ile Trp 
            180                 185                 190         


Ser Glu Leu Gln Ala Tyr Ile Lys Glu His His Thr Thr Gly Leu Thr 
        195                 200                 205             


Trp Ser Lys Thr Gly Pro Val Ala Ser Thr Val Ser Ala Phe Ser Val 
    210                 215                 220                 


Leu Ser Ser Gly Pro Gly Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro 
225                 230                 235                 240 


Pro Gly Pro Pro Pro Leu Phe Glu Asn Glu Gly Lys Lys Glu Glu Ser 
                245                 250                 255     


Ser Pro Ser Arg Ser Ala Leu Phe Ala Gln Leu Asn Gln Gly Glu Ala 
            260                 265                 270         


Ile Thr Lys Gly Leu Arg His Val Thr Asp Asp Gln Lys Thr Tyr Lys 
        275                 280                 285             


Asn Pro Ser Leu Arg Ala Gln Gly Gly Gln Thr Gln Ser Pro Thr Lys 
    290                 295                 300                 


Ser His Thr Pro Ser Pro Thr Ser Pro Lys Ser Tyr Pro Ser Gln Lys 
305                 310                 315                 320 


His Ala Pro Val Leu Glu Leu Glu Gly Lys Lys Trp Arg Val Glu Tyr 
                325                 330                 335     


Gln Glu Asp Arg Asn Asp Leu Val Ile Ser Glu Thr Glu Leu Lys Gln 
            340                 345                 350         


Val Ala Tyr Ile Phe Lys Cys Glu Lys Ser Thr Ile Gln Ile Lys Gly 
        355                 360                 365             


Lys Val Asn Ser Ile Ile Ile Asp Asn Cys Lys Lys Leu Gly Leu Val 
    370                 375                 380                 


Phe Asp Asn Val Val Gly Ile Val Glu Val Ile Asn Ser Gln Asp Ile 
385                 390                 395                 400 


Gln Ile Gln Val Met Gly Arg Val Pro Thr Ile Ser Ile Asn Lys Thr 
                405                 410                 415     


Glu Gly Cys His Ile Tyr Leu Ser Glu Asp Ala Leu Asp Cys Glu Ile 
            420                 425                 430         


Val Ser Ala Lys Ser Ser Glu Met Asn Ile Leu Ile Pro Gln Asp Gly 
        435                 440                 445             


Asp Tyr Arg Glu Phe Pro Ile Pro Glu Gln Phe Lys Thr Ala Trp Asp 
    450                 455                 460                 


Gly Ser Lys Leu Ile Thr Glu Pro Ala Glu Ile Met Ala 
465                 470                 475         


<210>  1567
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPG__Homo_sapiens__NP_001243069

<400>  1567

Met Tyr Thr Ala Ile Pro Gln Ser Gly Ser Pro Phe Pro Gly Ser Val 
1               5                   10                  15      


Gln Asp Pro Gly Leu His Val Trp Arg Val Glu Lys Leu Lys Pro Val 
            20                  25                  30          


Pro Val Ala Gln Glu Asn Gln Gly Val Phe Phe Ser Gly Asp Ser Tyr 
        35                  40                  45              


Leu Val Leu His Asn Gly Pro Glu Glu Val Ser His Leu His Leu Trp 
    50                  55                  60                  


Ile Gly Gln Gln Ser Ser Arg Asp Glu Gln Gly Ala Cys Ala Val Leu 
65                  70                  75                  80  


Ala Val His Leu Asn Thr Leu Leu Gly Glu Arg Pro Val Gln His Arg 
                85                  90                  95      


Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro Arg 
            100                 105                 110         


Gly Leu Lys Tyr Gln Glu Gly Gly Val Glu Ser Ala Phe His Lys Thr 
        115                 120                 125             


Ser Thr Gly Ala Pro Ala Ala Ile Lys Lys Leu Tyr Gln Val Lys Gly 
    130                 135                 140                 


Lys Lys Asn Ile Arg Ala Thr Glu Arg Ala Leu Asn Trp Asp Ser Phe 
145                 150                 155                 160 


Asn Thr Gly Asp Cys Phe Ile Leu Asp Leu Gly Gln Asn Ile Phe Ala 
                165                 170                 175     


Trp Cys Gly Gly Lys Ser Asn Ile Leu Glu Arg Asn Lys Ala Arg Asp 
            180                 185                 190         


Leu Ala Leu Ala Ile Arg Asp Ser Glu Arg Gln Gly Lys Ala Gln Val 
        195                 200                 205             


Leu Gly Pro Lys Pro Ala Leu Lys Glu Gly Asn Pro Glu Glu Asp Leu 
    210                 215                 220                 


Thr Ala Asp Lys Ala Asn Ala Gln Ala Ala Ala Leu Tyr Lys Val Ser 
225                 230                 235                 240 


Asp Ala Thr Gly Gln Met Asn Leu Thr Lys Val Ala Asp Ser Ser Pro 
                245                 250                 255     


Phe Ala Leu Glu Leu Leu Ile Ser Asp Asp Cys Phe Val Leu Asp Asn 
            260                 265                 270         


Gly Leu Cys Gly Lys Ile Tyr Ile Trp Lys Gly Arg Lys Ala Asn Glu 
        275                 280                 285             


Lys Glu Arg Gln Ala Ala Leu Gln Val Ala Glu Gly Phe Ile Ser Arg 
    290                 295                 300                 


Met Gln Tyr Ala Pro Asn Thr Gln Val Glu Ile Leu Pro Gln Gly His 
305                 310                 315                 320 


Glu Ser Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Lys 
                325                 330             


<210>  1568
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN10__Homo_sapiens__NP_075571

<400>  1568

Met Arg Ala Gly Arg Gly Ala Thr Pro Ala Arg Glu Leu Phe Arg Asp 
1               5                   10                  15      


Ala Ala Phe Pro Ala Ala Asp Ser Ser Leu Phe Cys Asp Leu Ser Thr 
            20                  25                  30          


Pro Leu Ala Gln Phe Arg Glu Asp Ile Thr Trp Arg Arg Pro Gln Glu 
        35                  40                  45              


Ile Cys Ala Thr Pro Arg Leu Phe Pro Asp Asp Pro Arg Glu Gly Gln 
    50                  55                  60                  


Val Lys Gln Gly Leu Leu Gly Asp Cys Trp Phe Leu Cys Ala Cys Ala 
65                  70                  75                  80  


Ala Leu Gln Lys Ser Arg His Leu Leu Asp Gln Val Ile Pro Pro Gly 
                85                  90                  95      


Gln Pro Ser Trp Ala Asp Gln Glu Tyr Arg Gly Ser Phe Thr Cys Arg 
            100                 105                 110         


Ile Trp Gln Phe Gly Arg Trp Val Glu Val Thr Thr Asp Asp Arg Leu 
        115                 120                 125             


Pro Cys Leu Ala Gly Arg Leu Cys Phe Ser Arg Cys Gln Arg Glu Asp 
    130                 135                 140                 


Val Phe Trp Leu Pro Leu Leu Glu Lys Val Tyr Ala Lys Val His Gly 
145                 150                 155                 160 


Ser Tyr Glu His Leu Trp Ala Gly Gln Val Ala Asp Ala Leu Val Asp 
                165                 170                 175     


Leu Thr Gly Gly Leu Ala Glu Arg Trp Asn Leu Lys Gly Val Ala Gly 
            180                 185                 190         


Ser Gly Gly Gln Gln Asp Arg Pro Gly Arg Trp Glu His Arg Thr Cys 
        195                 200                 205             


Arg Gln Leu Leu His Leu Lys Asp Gln Cys Leu Ile Ser Cys Cys Val 
    210                 215                 220                 


Leu Ser Pro Arg Ala Gly Ala Arg Glu Leu Gly Glu Phe His Ala Phe 
225                 230                 235                 240 


Ile Val Ser Asp Leu Arg Glu Leu Gln Gly Gln Ala Gly Gln Cys Ile 
                245                 250                 255     


Leu Leu Leu Arg Ile Gln Asn Pro Trp Gly Arg Arg Cys Trp Gln Gly 
            260                 265                 270         


Leu Trp Arg Glu Gly Gly Glu Gly Trp Ser Gln Val Asp Ala Ala Val 
        275                 280                 285             


Ala Ser Glu Leu Leu Ser Gln Leu Gln Glu Gly Glu Phe Trp Val Glu 
    290                 295                 300                 


Glu Glu Glu Phe Leu Arg Glu Phe Asp Glu Leu Thr Val Gly Tyr Pro 
305                 310                 315                 320 


Val Thr Glu Ala Gly His Leu Gln Ser Leu Tyr Thr Glu Arg Leu Leu 
                325                 330                 335     


Cys His Thr Arg Ala Leu Pro Gly Ala Trp Val Lys Gly Gln Ser Ala 
            340                 345                 350         


Gly Gly Cys Arg Asn Asn Ser Gly Phe Pro Ser Asn Pro Lys Phe Trp 
        355                 360                 365             


Leu Arg Val Ser Glu Pro Ser Glu Val Tyr Ile Ala Val Leu Gln Arg 
    370                 375                 380                 


Ser Arg Leu His Ala Ala Asp Trp Ala Gly Arg Ala Arg Ala Leu Val 
385                 390                 395                 400 


Gly Asp Ser His Thr Ser Trp Ser Pro Ala Ser Ile Pro Gly Lys His 
                405                 410                 415     


Tyr Gln Ala Val Gly Leu His Leu Trp Lys Val Glu Lys Arg Arg Val 
            420                 425                 430         


Asn Leu Pro Arg Val Leu Ser Met Pro Pro Val Ala Gly Thr Ala Cys 
        435                 440                 445             


His Ala Tyr Asp Arg Glu Val His Leu Arg Cys Glu Leu Ser Pro Gly 
    450                 455                 460                 


Tyr Tyr Leu Ala Val Pro Ser Thr Phe Leu Lys Asp Ala Pro Gly Glu 
465                 470                 475                 480 


Phe Leu Leu Arg Val Phe Ser Thr Gly Arg Val Ser Leu Ser Ala Ile 
                485                 490                 495     


Arg Ala Val Ala Lys Asn Thr Thr Pro Gly Ala Ala Leu Pro Ala Gly 
            500                 505                 510         


Glu Trp Gly Thr Val Gln Leu Arg Gly Ser Trp Arg Val Gly Gln Thr 
        515                 520                 525             


Ala Gly Gly Ser Arg Asn Phe Ala Ser Tyr Pro Thr Asn Pro Cys Phe 
    530                 535                 540                 


Pro Phe Ser Val Pro Glu Gly Pro Gly Pro Arg Cys Val Arg Ile Thr 
545                 550                 555                 560 


Leu His Gln His Cys Arg Pro Ser Asp Thr Glu Phe His Pro Ile Gly 
                565                 570                 575     


Phe His Ile Phe Gln Val Pro Glu Gly Gly Arg Ser Gln Asp Ala Pro 
            580                 585                 590         


Pro Leu Leu Leu Gln Glu Pro Leu Leu Ser Cys Val Pro His Arg Tyr 
        595                 600                 605             


Ala Gln Glu Val Ser Arg Leu Cys Leu Leu Pro Ala Gly Thr Tyr Lys 
    610                 615                 620                 


Val Val Pro Ser Thr Tyr Leu Pro Asp Thr Glu Gly Ala Phe Thr Val 
625                 630                 635                 640 


Thr Ile Ala Thr Arg Ile Asp Arg Pro Ser Ile His Ser Gln Glu Met 
                645                 650                 655     


Leu Gly Gln Phe Leu Gln Glu Val Ser Val Met Ala Val Met Lys Thr 
            660                 665                 670         


<210>  1569
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN13__Homo_sapiens__NP_653176

<400>  1569

Met Ala Tyr Tyr Gln Glu Pro Ser Val Glu Thr Ser Ile Ile Lys Phe 
1               5                   10                  15      


Lys Asp Gln Asp Phe Thr Thr Leu Arg Asp His Cys Leu Ser Met Gly 
            20                  25                  30          


Arg Thr Phe Lys Asp Glu Thr Phe Pro Ala Ala Asp Ser Ser Ile Gly 
        35                  40                  45              


Gln Lys Leu Leu Gln Glu Lys Arg Leu Ser Asn Val Ile Trp Lys Arg 
    50                  55                  60                  


Pro Gln Asp Leu Pro Gly Gly Pro Pro His Phe Ile Leu Asp Asp Ile 
65                  70                  75                  80  


Ser Arg Phe Asp Ile Gln Gln Gly Gly Ala Ala Asp Cys Trp Phe Leu 
                85                  90                  95      


Ala Ala Leu Gly Ser Leu Thr Gln Asn Pro Gln Tyr Arg Gln Lys Ile 
            100                 105                 110         


Leu Met Val Gln Ser Phe Ser His Gln Tyr Ala Gly Ile Phe Arg Phe 
        115                 120                 125             


Arg Phe Trp Gln Cys Gly Gln Trp Val Glu Val Val Ile Asp Asp Arg 
    130                 135                 140                 


Leu Pro Val Gln Gly Asp Lys Cys Leu Phe Val Arg Pro Arg His Gln 
145                 150                 155                 160 


Asn Gln Glu Phe Trp Pro Cys Leu Leu Glu Lys Ala Tyr Ala Lys Leu 
                165                 170                 175     


Leu Gly Ser Tyr Ser Asp Leu His Tyr Gly Phe Leu Glu Asp Ala Leu 
            180                 185                 190         


Val Asp Leu Thr Gly Gly Val Ile Thr Asn Ile His Leu His Ser Ser 
        195                 200                 205             


Pro Val Asp Leu Val Lys Ala Val Lys Thr Ala Thr Lys Ala Gly Ser 
    210                 215                 220                 


Leu Ile Thr Cys Ala Thr Pro Ser Gly Pro Thr Asp Thr Ala Gln Ala 
225                 230                 235                 240 


Met Glu Asn Gly Leu Val Ser Leu His Ala Tyr Thr Val Thr Gly Ala 
                245                 250                 255     


Glu Gln Ile Gln Tyr Arg Arg Gly Trp Glu Glu Ile Ile Ser Leu Trp 
            260                 265                 270         


Asn Pro Trp Gly Trp Gly Glu Ala Glu Trp Arg Gly Arg Trp Ser Asp 
        275                 280                 285             


Gly Ser Gln Glu Trp Glu Glu Thr Cys Asp Pro Arg Lys Ser Gln Leu 
    290                 295                 300                 


His Lys Lys Arg Glu Asp Gly Glu Phe Trp Met Ser Cys Gln Asp Phe 
305                 310                 315                 320 


Gln Gln Lys Phe Ile Ala Met Phe Ile Cys Ser Glu Ile Pro Ile Thr 
                325                 330                 335     


Leu Asp His Gly Asn Thr Leu His Glu Gly Trp Ser Gln Ile Met Phe 
            340                 345                 350         


Arg Lys Gln Val Ile Leu Gly Asn Thr Ala Gly Gly Pro Arg Asn Asp 
        355                 360                 365             


Ala Gln Phe Asn Phe Ser Val Gln Glu Pro Met Glu Gly Thr Asn Val 
    370                 375                 380                 


Val Val Cys Val Thr Val Ala Val Thr Pro Ser Asn Leu Lys Ala Glu 
385                 390                 395                 400 


Asp Ala Lys Phe Pro Leu Asp Phe Gln Val Ile Leu Ala Gly Ser Gln 
                405                 410                 415     


Arg Phe Arg Glu Lys Phe Pro Pro Val Phe Phe Ser Ser Phe Arg Asn 
            420                 425                 430         


Thr Val Gln Ser Ser Asn Asn Lys Phe Arg Arg Asn Phe Thr Met Thr 
        435                 440                 445             


Tyr His Leu Ser Pro Gly Asn Tyr Val Val Val Ala Gln Thr Arg Arg 
    450                 455                 460                 


Lys Ser Ala Glu Phe Leu Leu Arg Ile Phe Leu Lys Met Pro Asp Ser 
465                 470                 475                 480 


Asp Arg His Leu Ser Ser His Phe Asn Leu Arg Met Lys Gly Ser Pro 
                485                 490                 495     


Ser Glu His Gly Ser Gln Gln Ser Ile Phe Asn Arg Tyr Ala Gln Gln 
            500                 505                 510         


Arg Leu Asp Ile Asp Ala Thr Gln Leu Gln Gly Leu Leu Asn Gln Glu 
        515                 520                 525             


Leu Leu Thr Gly Pro Pro Gly Asp Met Phe Ser Leu Asp Glu Cys Arg 
    530                 535                 540                 


Ser Leu Val Ala Leu Met Glu Leu Lys Val Asn Gly Arg Leu Asp Gln 
545                 550                 555                 560 


Glu Glu Phe Ala Arg Leu Trp Lys Arg Leu Val His Tyr Gln His Val 
                565                 570                 575     


Phe Gln Lys Val Gln Thr Ser Pro Gly Val Leu Leu Ser Ser Asp Leu 
            580                 585                 590         


Trp Lys Ala Ile Glu Asn Thr Asp Phe Leu Arg Gly Ile Phe Ile Ser 
        595                 600                 605             


Arg Glu Leu Leu His Leu Val Thr Leu Arg Tyr Ser Asp Ser Val Gly 
    610                 615                 620                 


Arg Val Ser Phe Pro Ser Leu Val Cys Phe Leu Met Arg Leu Glu Ala 
625                 630                 635                 640 


Met Ala Lys Thr Phe Arg Asn Leu Ser Lys Asp Gly Lys Gly Leu Tyr 
                645                 650                 655     


Leu Thr Glu Met Glu Trp Met Ser Leu Val Met Tyr Asn 
            660                 665                 


<210>  1570
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN14__Homo_sapiens__NP_001138594

<400>  1570

Met Ser Leu Trp Pro Pro Phe Arg Cys Arg Trp Lys Leu Ala Pro Arg 
1               5                   10                  15      


Tyr Ser Arg Arg Ala Ser Pro Gln Gln Pro Gln Gln Asp Phe Glu Ala 
            20                  25                  30          


Leu Leu Ala Glu Cys Leu Arg Asn Gly Cys Leu Phe Glu Asp Thr Ser 
        35                  40                  45              


Phe Pro Ala Thr Leu Ser Ser Ile Gly Ser Gly Ser Leu Leu Gln Lys 
    50                  55                  60                  


Leu Pro Pro Arg Leu Gln Trp Lys Arg Pro Pro Glu Leu His Ser Asn 
65                  70                  75                  80  


Pro Gln Phe Tyr Phe Ala Lys Ala Lys Arg Leu Asp Leu Cys Gln Gly 
                85                  90                  95      


Ile Val Gly Asp Cys Trp Phe Leu Ala Ala Leu Gln Ala Leu Ala Leu 
            100                 105                 110         


His Gln Asp Ile Leu Ser Arg Val Val Pro Leu Asn Gln Ser Phe Thr 
        115                 120                 125             


Glu Lys Tyr Ala Gly Ile Phe Arg Phe Trp Phe Trp His Tyr Gly Asn 
    130                 135                 140                 


Trp Val Pro Val Val Ile Asp Asp Arg Leu Pro Val Asn Glu Ala Gly 
145                 150                 155                 160 


Gln Leu Val Phe Val Ser Ser Thr Tyr Lys Asn Leu Phe Trp Gly Ala 
                165                 170                 175     


Leu Leu Glu Lys Ala Tyr Ala Lys Leu Ser Gly Ser Tyr Glu Asp Leu 
            180                 185                 190         


Gln Ser Gly Gln Val Ser Glu Ala Leu Val Asp Phe Thr Gly Gly Val 
        195                 200                 205             


Thr Met Thr Ile Asn Leu Ala Glu Ala His Gly Asn Leu Trp Asp Ile 
    210                 215                 220                 


Leu Ile Glu Ala Thr Tyr Asn Arg Thr Leu Ile Gly Cys Gln Thr His 
225                 230                 235                 240 


Ser Gly Glu Lys Ile Leu Glu Asn Gly Leu Val Glu Gly His Ala Tyr 
                245                 250                 255     


Thr Leu Thr Gly Ile Arg Lys Val Thr Cys Lys His Arg Pro Glu Tyr 
            260                 265                 270         


Leu Val Lys Leu Arg Asn Pro Trp Gly Lys Val Glu Trp Lys Gly Asp 
        275                 280                 285             


Trp Ser Asp Ser Ser Ser Lys Trp Glu Leu Leu Ser Pro Lys Glu Lys 
    290                 295                 300                 


Ile Leu Leu Leu Arg Lys Asp Asn Asp Gly Glu Phe Trp Met Thr Leu 
305                 310                 315                 320 


Gln Asp Phe Lys Thr His Phe Val Leu Leu Val Ile Cys Lys Leu Thr 
                325                 330                 335     


Pro Gly Leu Leu Ser Gln Glu Ala Ala Gln Lys Trp Thr Tyr Thr Met 
            340                 345                 350         


Arg Glu Gly Arg Trp Glu Lys Arg Ser Thr Ala Gly Gly Gln Arg Gln 
        355                 360                 365             


Leu Leu Gln Asp Thr Phe Trp Lys Asn Pro Gln Phe Leu Leu Ser Val 
    370                 375                 380                 


Trp Arg Pro Glu Glu Gly Arg Arg Ser Leu Arg Pro Cys Ser Val Leu 
385                 390                 395                 400 


Val Ser Leu Leu Gln Lys Pro Arg His Arg Cys Arg Lys Arg Lys Pro 
                405                 410                 415     


Leu Leu Ala Ile Gly Phe Tyr Leu Tyr Arg Met Asn Lys Tyr His Asp 
            420                 425                 430         


Asp Gln Arg Arg Leu Pro Pro Glu Phe Phe Gln Arg Asn Thr Pro Leu 
        435                 440                 445             


Ser Gln Pro Asp Arg Phe Leu Lys Glu Lys Glu Val Ser Gln Glu Leu 
    450                 455                 460                 


Cys Leu Glu Pro Gly Thr Tyr Leu Ile Val Pro Cys Ile Leu Glu Ala 
465                 470                 475                 480 


His Gln Lys Ser Glu Phe Val Leu Arg Val Phe Ser Arg Lys His Ile 
                485                 490                 495     


Phe Tyr Glu Ile Gly Ser Asn Ser Gly Val Val Phe Ser Lys Glu Ile 
            500                 505                 510         


Glu Asp Gln Asn Glu Arg Gln Asp Glu Phe Phe Thr Lys Phe Phe Glu 
        515                 520                 525             


Lys His Pro Glu Ile Asn Ala Val Gln Leu Gln Asn Leu Leu Asn Gln 
    530                 535                 540                 


Met Thr Trp Ser Ser Leu Gly Ser Arg Gln Pro Phe Phe Ser Leu Glu 
545                 550                 555                 560 


Ala Cys Gln Gly Ile Leu Ala Leu Leu Asp Leu Asn Ala Ser Gly Thr 
                565                 570                 575     


Met Ser Ile Gln Glu Phe Arg Asp Leu Trp Lys Gln Leu Lys Leu Ser 
            580                 585                 590         


Gln Lys Val Phe His Lys Gln Asp Arg Gly Ser Gly Tyr Leu Asn Trp 
        595                 600                 605             


Glu Gln Leu His Ala Ala Met Arg Glu Ala Gly Ile Met Leu Ser Asp 
    610                 615                 620                 


Asp Val Cys Gln Leu Met Leu Ile Arg Tyr Gly Gly Pro Arg Leu Gln 
625                 630                 635                 640 


Met Asp Phe Val Ser Phe Ile His Leu Met Leu Arg Val Glu Asn Met 
                645                 650                 655     


Glu Asp Val Phe Gln Asn Leu Thr Gln Asp Gly Lys Gly Ile Tyr Leu 
            660                 665                 670         


Gln Lys Pro Glu Trp Met Met Met Ala Leu Tyr Ser 
        675                 680                 


<210>  1571
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN1__Homo_sapiens__XP_011543594

<400>  1571

Met Ser Glu Glu Ile Ile Thr Pro Val Tyr Cys Thr Gly Val Ser Ala 
1               5                   10                  15      


Gln Val Gln Lys Gln Arg Ala Arg Glu Leu Gly Leu Gly Arg His Glu 
            20                  25                  30          


Asn Ala Ile Lys Tyr Leu Gly Gln Asp Tyr Glu Gln Leu Arg Val Arg 
        35                  40                  45              


Cys Leu Gln Ser Gly Thr Leu Phe Arg Asp Glu Ala Phe Pro Pro Val 
    50                  55                  60                  


Pro Gln Ser Leu Gly Tyr Lys Asp Leu Gly Pro Asn Ser Ser Lys Thr 
65                  70                  75                  80  


Tyr Gly Ile Lys Trp Lys Arg Pro Thr Glu Leu Leu Ser Asn Pro Gln 
                85                  90                  95      


Phe Ile Val Asp Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Ala Leu 
            100                 105                 110         


Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Asp 
        115                 120                 125             


Thr Leu Leu His Arg Val Val Pro His Gly Gln Ser Phe Gln Asn Gly 
    130                 135                 140                 


Tyr Ala Gly Ile Phe His Phe Gln Leu Trp Gln Phe Gly Glu Trp Val 
145                 150                 155                 160 


Asp Val Val Val Asp Asp Leu Leu Pro Ile Lys Asp Gly Lys Leu Val 
                165                 170                 175     


Phe Val His Ser Ala Glu Gly Asn Glu Phe Trp Ser Ala Leu Leu Glu 
            180                 185                 190         


Lys Ala Tyr Ala Lys Val Asn Gly Ser Tyr Glu Ala Leu Ser Gly Gly 
        195                 200                 205             


Ser Thr Ser Glu Gly Phe Glu Asp Phe Thr Gly Gly Val Thr Glu Trp 
    210                 215                 220                 


Tyr Glu Leu Arg Lys Ala Pro Ser Asp Leu Tyr Gln Ile Ile Leu Lys 
225                 230                 235                 240 


Ala Leu Glu Arg Gly Ser Leu Leu Gly Cys Ser Ile Asp Ile Ser Ser 
                245                 250                 255     


Val Leu Asp Met Glu Ala Ile Thr Phe Lys Lys Leu Val Lys Gly His 
            260                 265                 270         


Ala Tyr Ser Val Thr Gly Ala Lys Gln Val Asn Tyr Arg Gly Gln Val 
        275                 280                 285             


Val Ser Leu Ile Arg Met Arg Asn Pro Trp Gly Glu Val Glu Trp Thr 
    290                 295                 300                 


Gly Ala Trp Ser Asp Ser Ser Ser Glu Trp Asn Asn Val Asp Pro Tyr 
305                 310                 315                 320 


Glu Arg Asp Gln Leu Arg Val Lys Met Glu Asp Gly Glu Phe Trp Met 
                325                 330                 335     


Ser Phe Arg Asp Phe Met Arg Glu Phe Thr Arg Leu Glu Ile Cys Asn 
            340                 345                 350         


Leu Thr Pro Asp Ala Leu Lys Ser Arg Thr Ile Arg Lys Trp Asn Thr 
        355                 360                 365             


Thr Leu Tyr Glu Gly Thr Trp Arg Arg Gly Ser Thr Ala Gly Gly Cys 
    370                 375                 380                 


Arg Asn Tyr Pro Ala Thr Phe Trp Val Asn Pro Gln Phe Lys Ile Arg 
385                 390                 395                 400 


Leu Asp Glu Thr Asp Asp Pro Asp Asp Tyr Gly Asp Arg Glu Ser Gly 
                405                 410                 415     


Cys Ser Phe Val Leu Ala Leu Met Gln Lys His Arg Arg Arg Glu Arg 
            420                 425                 430         


Arg Phe Gly Arg Asp Met Glu Thr Ile Gly Phe Ala Val Tyr Glu Val 
        435                 440                 445             


Pro Pro Glu Leu Val Gly Gln Pro Ala Val His Leu Lys Arg Asp Phe 
    450                 455                 460                 


Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln Phe Ile Asn Leu 
465                 470                 475                 480 


Arg Glu Val Ser Thr Arg Phe Arg Leu Pro Pro Gly Glu Tyr Val Val 
                485                 490                 495     


Val Pro Ser Thr Phe Glu Pro Asn Lys Glu Gly Asp Phe Val Leu Arg 
            500                 505                 510         


Phe Phe Ser Glu Lys Ser Ala Gly Thr Val Glu Leu Asp Asp Gln Ile 
        515                 520                 525             


Gln Ala Asn Leu Pro Asp Glu Gln Val Leu Ser Glu Glu Glu Ile Asp 
    530                 535                 540                 


Glu Asn Phe Lys Ala Leu Phe Arg Gln Leu Ala Gly Glu Asp Met Glu 
545                 550                 555                 560 


Ile Ser Val Lys Glu Leu Arg Thr Ile Leu Asn Arg Ile Ile Ser Lys 
                565                 570                 575     


His Lys Asp Leu Arg Thr Lys Gly Phe Ser Leu Glu Ser Cys Arg Ser 
            580                 585                 590         


Met Val Asn Leu Met Asp Arg Asp Gly Asn Gly Lys Leu Gly Leu Val 
        595                 600                 605             


Glu Phe Asn Ile Leu Trp Asn Arg Ile Arg Asn Tyr Leu Ser Ile Phe 
    610                 615                 620                 


Arg Lys Phe Asp Leu Asp Lys Ser Gly Ser Met Ser Ala Tyr Glu Met 
625                 630                 635                 640 


Arg Met Ala Ile Glu Ser Ala Gly Phe Lys Leu Asn Lys Lys Leu Tyr 
                645                 650                 655     


Glu Leu Ile Ile Thr Arg Tyr Ser Glu Pro Asp Leu Ala Val Asp Phe 
            660                 665                 670         


Asp Asn Phe Val Cys Cys Leu Val Arg Leu Glu Thr Met Phe Arg Phe 
        675                 680                 685             


Phe Lys Thr Leu Asp Thr Asp Leu Asp Gly Val Val Thr Phe Asp Leu 
    690                 695                 700                 


Phe Lys Trp Leu Gln Leu Thr Met Phe Ala 
705                 710                 


<210>  1572
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN2__Homo_sapiens__NP_001139540

<400>  1572

Met Glu Ile Cys Ala Asp Pro Gln Phe Ile Ile Gly Gly Ala Thr Arg 
1               5                   10                  15      


Thr Asp Ile Cys Gln Gly Ala Leu Gly Asp Cys Trp Leu Leu Ala Ala 
            20                  25                  30          


Ile Ala Ser Leu Thr Leu Asn Glu Glu Ile Leu Ala Arg Val Val Pro 
        35                  40                  45              


Leu Asn Gln Ser Phe Gln Glu Asn Tyr Ala Gly Ile Phe His Phe Gln 
    50                  55                  60                  


Phe Trp Gln Tyr Gly Glu Trp Val Glu Val Val Val Asp Asp Arg Leu 
65                  70                  75                  80  


Pro Thr Lys Asp Gly Glu Leu Leu Phe Val His Ser Ala Glu Gly Ser 
                85                  90                  95      


Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala Tyr Ala Lys Ile Asn Gly 
            100                 105                 110         


Cys Tyr Glu Ala Leu Ser Gly Gly Ala Thr Thr Glu Gly Phe Glu Asp 
        115                 120                 125             


Phe Thr Gly Gly Ile Ala Glu Trp Tyr Glu Leu Lys Lys Pro Pro Pro 
    130                 135                 140                 


Asn Leu Phe Lys Ile Ile Gln Lys Ala Leu Gln Lys Gly Ser Leu Leu 
145                 150                 155                 160 


Gly Cys Ser Ile Asp Ile Thr Ser Ala Ala Asp Ser Glu Ala Ile Thr 
                165                 170                 175     


Phe Gln Lys Leu Val Lys Gly His Ala Tyr Ser Val Thr Gly Ala Glu 
            180                 185                 190         


Glu Val Glu Ser Asn Gly Ser Leu Gln Lys Leu Ile Arg Ile Arg Asn 
        195                 200                 205             


Pro Trp Gly Glu Val Glu Trp Thr Gly Arg Trp Asn Asp Asn Cys Pro 
    210                 215                 220                 


Ser Trp Asn Thr Ile Asp Pro Glu Glu Arg Glu Arg Leu Thr Arg Arg 
225                 230                 235                 240 


His Glu Asp Gly Glu Phe Trp Met Ser Phe Ser Asp Phe Leu Arg His 
                245                 250                 255     


Tyr Ser Arg Leu Glu Ile Cys Asn Leu Thr Pro Asp Thr Leu Thr Ser 
            260                 265                 270         


Asp Thr Tyr Lys Lys Trp Lys Leu Thr Lys Met Asp Gly Asn Trp Arg 
        275                 280                 285             


Arg Gly Ser Thr Ala Gly Gly Cys Arg Asn Tyr Pro Asn Thr Phe Trp 
    290                 295                 300                 


Met Asn Pro Gln Tyr Leu Ile Lys Leu Glu Glu Glu Asp Glu Asp Glu 
305                 310                 315                 320 


Glu Asp Gly Glu Ser Gly Cys Thr Phe Leu Val Gly Leu Ile Gln Lys 
                325                 330                 335     


His Arg Arg Arg Gln Arg Lys Met Gly Glu Asp Met His Thr Ile Gly 
            340                 345                 350         


Phe Gly Ile Tyr Glu Val Pro Glu Glu Leu Ser Gly Gln Thr Asn Ile 
        355                 360                 365             


His Leu Ser Lys Asn Phe Phe Leu Thr Asn Arg Ala Arg Glu Arg Ser 
    370                 375                 380                 


Asp Thr Phe Ile Asn Leu Arg Glu Val Leu Asn Arg Phe Lys Leu Pro 
385                 390                 395                 400 


Pro Gly Glu Tyr Ile Leu Val Pro Ser Thr Phe Glu Pro Asn Lys Asp 
                405                 410                 415     


Gly Asp Phe Cys Ile Arg Val Phe Ser Glu Lys Lys Ala Asp Tyr Gln 
            420                 425                 430         


Ala Val Asp Asp Glu Ile Glu Ala Asn Leu Glu Glu Phe Asp Ile Ser 
        435                 440                 445             


Glu Asp Asp Ile Asp Asp Gly Phe Arg Arg Leu Phe Ala Gln Leu Ala 
    450                 455                 460                 


Gly Glu Asp Ala Glu Ile Ser Ala Phe Glu Leu Gln Thr Ile Leu Arg 
465                 470                 475                 480 


Arg Val Leu Ala Lys Arg Gln Asp Ile Lys Ser Asp Gly Phe Ser Ile 
                485                 490                 495     


Glu Thr Cys Lys Ile Met Val Asp Met Leu Asp Ser Asp Gly Ser Gly 
            500                 505                 510         


Lys Leu Gly Leu Lys Glu Phe Tyr Ile Leu Trp Thr Lys Ile Gln Lys 
        515                 520                 525             


Tyr Gln Lys Ile Tyr Arg Glu Ile Asp Val Asp Arg Ser Gly Thr Met 
    530                 535                 540                 


Asn Ser Tyr Glu Met Arg Lys Ala Leu Glu Glu Ala Gly Phe Lys Met 
545                 550                 555                 560 


Pro Cys Gln Leu His Gln Val Ile Val Ala Arg Phe Ala Asp Asp Gln 
                565                 570                 575     


Leu Ile Ile Asp Phe Asp Asn Phe Val Arg Cys Leu Val Arg Leu Glu 
            580                 585                 590         


Thr Leu Phe Lys Ile Phe Lys Gln Leu Asp Pro Glu Asn Thr Gly Thr 
        595                 600                 605             


Ile Glu Leu Asp Leu Ile Ser Trp Leu Cys Phe Ser Val Leu 
    610                 615                 620         


<210>  1573
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN3__Homo_sapiens__NP_000061

<400>  1573

Met Pro Thr Val Ile Ser Ala Ser Val Ala Pro Arg Thr Ala Ala Glu 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Thr 
            20                  25                  30          


Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              


Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Thr Phe Glu Gln Leu 
    50                  55                  60                  


His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  


Pro Pro Asp Glu Thr Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      


Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         


Ile Asp Gly Ala Asn Arg Thr Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             


Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Thr Leu Asn Gln His Leu 
    130                 135                 140                 


Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 


Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     


Val Ile Asp Asp Cys Leu Pro Thr Tyr Asn Asn Gln Leu Val Phe Thr 
            180                 185                 190         


Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             


Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Thr 
    210                 215                 220                 


Thr Glu Ala Met Glu Asp Phe Thr Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 


Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     


Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Thr Asn Met 
            260                 265                 270         


Thr Tyr Gly Thr Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
        275                 280                 285             


Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Gln Asp Ser Asp Leu 
    290                 295                 300                 


Asp Pro Arg Gly Ser Asp Glu Arg Pro Thr Arg Thr Ile Ile Pro Val 
305                 310                 315                 320 


Gln Tyr Glu Thr Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
                325                 330                 335     


Ser Val Thr Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
        355                 360                 365             


Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
    370                 375                 380                 


Ala Arg Leu Gln His Gln Val Thr Glu Asp Gly Glu Phe Trp Met Ser 
385                 390                 395                 400 


Tyr Glu Asp Phe Ile Tyr His Phe Thr Lys Leu Glu Ile Cys Asn Leu 
                405                 410                 415     


Thr Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Thr Trp Thr Val Ser 
            420                 425                 430         


Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
        435                 440                 445             


Asn Phe Pro Asp Thr Phe Trp Thr Asn Pro Gln Tyr Arg Leu Lys Leu 
    450                 455                 460                 


Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
465                 470                 475                 480 


Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                485                 490                 495     


Ala Ser Leu Phe Thr Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
            500                 505                 510         


Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
        515                 520                 525             


Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
    530                 535                 540                 


Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
545                 550                 555                 560 


Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                565                 570                 575     


Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Thr Ile Ser Val Asp Arg 
            580                 585                 590         


Pro Val Lys Lys Lys Lys Thr Lys Pro Ile Ile Phe Val Ser Asp Arg 
        595                 600                 605             


Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
    610                 615                 620                 


Lys Gly Lys Thr Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
625                 630                 635                 640 


Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
                645                 650                 655     


Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
            660                 665                 670         


Leu Lys Lys Val Leu Asn Thr Val Val Asn Lys His Lys Asp Leu Lys 
        675                 680                 685             


Thr His Gly Phe Thr Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
    690                 695                 700                 


Asp Thr Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
705                 710                 715                 720 


Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Thr 
                725                 730                 735     


Asp Gln Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
            740                 745                 750         


Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Thr Met 
        755                 760                 765             


Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
    770                 775                 780                 


Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
785                 790                 795                 800 


Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
                805                 810                 815     


Leu Thr Met Tyr Ala 
            820     


<210>  1574
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN5__Homo_sapiens__NP_004046

<400>  1574

Met Phe Ser Cys Val Lys Pro Tyr Glu Asp Gln Asn Tyr Ser Ala Leu 
1               5                   10                  15      


Arg Arg Asp Cys Arg Arg Arg Lys Val Leu Phe Glu Asp Pro Leu Phe 
            20                  25                  30          


Pro Ala Thr Asp Asp Ser Leu Tyr Tyr Lys Gly Thr Pro Gly Pro Ala 
        35                  40                  45              


Val Arg Trp Lys Arg Pro Lys Gly Ile Cys Glu Asp Pro Arg Leu Phe 
    50                  55                  60                  


Val Asp Gly Ile Ser Ser His Asp Leu His Gln Gly Gln Val Gly Asn 
65                  70                  75                  80  


Cys Trp Phe Val Ala Ala Cys Ser Ser Leu Ala Ser Arg Glu Ser Leu 
                85                  90                  95      


Trp Gln Lys Val Ile Pro Asp Trp Lys Glu Gln Glu Trp Asp Pro Glu 
            100                 105                 110         


Lys Pro Asn Ala Tyr Ala Gly Ile Phe His Phe His Phe Trp Arg Phe 
        115                 120                 125             


Gly Glu Trp Val Asp Val Val Ile Asp Asp Arg Leu Pro Thr Val Asn 
    130                 135                 140                 


Asn Gln Leu Ile Tyr Cys His Ser Asn Ser Arg Asn Glu Phe Trp Cys 
145                 150                 155                 160 


Ala Leu Val Glu Lys Ala Tyr Ala Lys Leu Ala Gly Cys Tyr Gln Ala 
                165                 170                 175     


Leu Asp Gly Gly Asn Thr Ala Asp Ala Leu Val Asp Phe Thr Gly Gly 
            180                 185                 190         


Val Ser Glu Pro Ile Asp Leu Thr Glu Gly Asp Phe Ala Asn Asp Glu 
        195                 200                 205             


Thr Lys Arg Asn Gln Leu Phe Glu Arg Met Leu Lys Val His Ser Arg 
    210                 215                 220                 


Gly Gly Leu Ile Ser Ala Ser Ile Lys Ala Val Thr Ala Ala Asp Met 
225                 230                 235                 240 


Glu Ala Arg Leu Ala Cys Gly Leu Val Lys Gly His Ala Tyr Ala Val 
                245                 250                 255     


Thr Asp Val Arg Lys Val Arg Leu Gly His Gly Leu Leu Ala Phe Phe 
            260                 265                 270         


Lys Ser Glu Lys Leu Asp Met Ile Arg Leu Arg Asn Pro Trp Gly Glu 
        275                 280                 285             


Arg Glu Trp Asn Gly Pro Trp Ser Asp Thr Ser Glu Glu Trp Gln Lys 
    290                 295                 300                 


Val Ser Lys Ser Glu Arg Glu Lys Met Gly Val Thr Val Gln Asp Asp 
305                 310                 315                 320 


Gly Glu Phe Trp Met Thr Phe Glu Asp Val Cys Arg Tyr Phe Thr Asp 
                325                 330                 335     


Ile Ile Lys Cys Arg Val Ile Asn Thr Ser His Leu Ser Ile His Lys 
            340                 345                 350         


Thr Trp Glu Glu Ala Arg Leu His Gly Ala Trp Thr Leu His Glu Asp 
        355                 360                 365             


Pro Arg Gln Asn Arg Gly Gly Gly Cys Ile Asn His Lys Asp Thr Phe 
    370                 375                 380                 


Phe Gln Asn Pro Gln Tyr Ile Phe Glu Val Lys Lys Pro Glu Asp Glu 
385                 390                 395                 400 


Val Leu Ile Cys Ile Gln Gln Arg Pro Lys Arg Ser Thr Arg Arg Glu 
                405                 410                 415     


Gly Lys Gly Glu Asn Leu Ala Ile Gly Phe Asp Ile Tyr Lys Val Glu 
            420                 425                 430         


Glu Asn Arg Gln Tyr Arg Met His Ser Leu Gln His Lys Ala Ala Ser 
        435                 440                 445             


Ser Ile Tyr Ile Asn Ser Arg Ser Val Phe Leu Arg Thr Asp Gln Pro 
    450                 455                 460                 


Glu Gly Arg Tyr Val Ile Ile Pro Thr Thr Phe Glu Pro Gly His Thr 
465                 470                 475                 480 


Gly Glu Phe Leu Leu Arg Val Phe Thr Asp Val Pro Ser Asn Cys Arg 
                485                 490                 495     


Glu Leu Arg Leu Asp Glu Pro Pro His Thr Cys Trp Ser Ser Leu Cys 
            500                 505                 510         


Gly Tyr Pro Gln Leu Val Thr Gln Val His Val Leu Gly Ala Ala Gly 
        515                 520                 525             


Leu Lys Asp Ser Pro Thr Gly Ala Asn Ser Tyr Val Ile Ile Lys Cys 
    530                 535                 540                 


Glu Gly Asp Lys Val Arg Ser Ala Val Gln Lys Gly Thr Ser Thr Pro 
545                 550                 555                 560 


Glu Tyr Asn Val Lys Gly Ile Phe Tyr Arg Lys Lys Leu Ser Gln Pro 
                565                 570                 575     


Ile Thr Val Gln Val Trp Asn His Arg Val Leu Lys Asp Glu Phe Leu 
            580                 585                 590         


Gly Gln Val His Leu Lys Ala Asp Pro Asp Asn Leu Gln Ala Leu His 
        595                 600                 605             


Thr Leu His Leu Arg Asp Arg Asn Ser Arg Gln Pro Ser Asn Leu Pro 
    610                 615                 620                 


Gly Thr Val Ala Val His Ile Leu Ser Ser Thr Ser Leu Met Ala Val 
625                 630                 635                 640 


<210>  1575
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN6__Homo_sapiens__NP_055104

<400>  1575

Met Gly Pro Pro Leu Lys Leu Phe Lys Asn Gln Lys Tyr Gln Glu Leu 
1               5                   10                  15      


Lys Gln Glu Cys Ile Lys Asp Ser Arg Leu Phe Cys Asp Pro Thr Phe 
            20                  25                  30          


Leu Pro Glu Asn Asp Ser Leu Phe Tyr Asn Arg Leu Leu Pro Gly Lys 
        35                  40                  45              


Val Val Trp Lys Arg Pro Gln Asp Ile Cys Asp Asp Pro His Leu Ile 
    50                  55                  60                  


Val Gly Asn Ile Ser Asn His Gln Leu Thr Gln Gly Arg Leu Gly His 
65                  70                  75                  80  


Lys Pro Met Val Ser Ala Phe Ser Cys Leu Ala Val Gln Glu Ser His 
                85                  90                  95      


Trp Thr Lys Thr Ile Pro Asn His Lys Glu Gln Glu Trp Asp Pro Gln 
            100                 105                 110         


Lys Thr Glu Lys Tyr Ala Gly Ile Phe His Phe Arg Phe Trp His Phe 
        115                 120                 125             


Gly Glu Trp Thr Glu Val Val Ile Asp Asp Leu Leu Pro Thr Ile Asn 
    130                 135                 140                 


Gly Asp Leu Val Phe Ser Phe Ser Thr Ser Met Asn Glu Phe Trp Asn 
145                 150                 155                 160 


Ala Leu Leu Glu Lys Ala Tyr Ala Lys Leu Leu Gly Cys Tyr Glu Ala 
                165                 170                 175     


Leu Asp Gly Leu Thr Ile Thr Asp Ile Ile Val Asp Phe Thr Gly Thr 
            180                 185                 190         


Leu Ala Glu Thr Val Asp Met Gln Lys Gly Arg Tyr Thr Glu Leu Val 
        195                 200                 205             


Glu Glu Lys Tyr Lys Leu Phe Gly Glu Leu Tyr Lys Thr Phe Thr Lys 
    210                 215                 220                 


Gly Gly Leu Ile Cys Cys Ser Ile Glu Ser Pro Asn Gln Glu Glu Gln 
225                 230                 235                 240 


Glu Val Glu Thr Asp Trp Gly Leu Leu Lys Gly His Thr Tyr Thr Met 
                245                 250                 255     


Thr Asp Ile Arg Lys Ile Arg Leu Gly Glu Arg Leu Val Glu Val Phe 
            260                 265                 270         


Ser Ala Glu Lys Val Tyr Met Val Arg Leu Arg Asn Pro Leu Gly Arg 
        275                 280                 285             


Gln Glu Trp Ser Gly Pro Trp Ser Glu Ile Ser Glu Glu Trp Gln Gln 
    290                 295                 300                 


Leu Thr Ala Ser Asp Arg Lys Asn Leu Gly Leu Val Met Ser Asp Asp 
305                 310                 315                 320 


Gly Glu Phe Trp Met Ser Leu Glu Asp Phe Cys Arg Asn Phe His Lys 
                325                 330                 335     


Leu Asn Val Cys Arg Asn Val Asn Asn Pro Ile Phe Gly Arg Lys Glu 
            340                 345                 350         


Leu Glu Ser Val Leu Gly Cys Trp Thr Val Asp Asp Asp Pro Leu Met 
        355                 360                 365             


Asn Arg Ser Gly Gly Cys Tyr Asn Asn Arg Asp Thr Phe Leu Gln Asn 
    370                 375                 380                 


Pro Gln Tyr Ile Phe Thr Val Pro Glu Asp Gly His Lys Val Ile Met 
385                 390                 395                 400 


Ser Leu Gln Gln Lys Asp Leu Arg Thr Tyr Arg Arg Met Gly Arg Pro 
                405                 410                 415     


Asp Asn Tyr Ile Ile Gly Phe Glu Leu Phe Lys Val Glu Met Asn Arg 
            420                 425                 430         


Lys Phe Arg Leu His His Leu Tyr Ile Gln Glu Arg Ala Gly Thr Ser 
        435                 440                 445             


Thr Tyr Ile Asp Thr Arg Thr Val Phe Leu Ser Lys Tyr Leu Lys Lys 
    450                 455                 460                 


Gly Asn Tyr Val Leu Val Pro Thr Met Phe Gln His Gly Arg Thr Ser 
465                 470                 475                 480 


Glu Phe Leu Leu Arg Ile Phe Ser Glu Val Pro Val Gln Leu Arg Glu 
                485                 490                 495     


Leu Thr Leu Asp Met Pro Lys Met Ser Cys Trp Asn Leu Ala Arg Gly 
            500                 505                 510         


Tyr Pro Lys Val Val Thr Gln Ile Thr Val His Ser Ala Glu Asp Leu 
        515                 520                 525             


Glu Lys Lys Tyr Ala Asn Glu Thr Val Asn Pro Tyr Leu Val Ile Lys 
    530                 535                 540                 


Cys Gly Lys Glu Glu Val Arg Ser Pro Val Gln Lys Asn Thr Val His 
545                 550                 555                 560 


Ala Ile Phe Asp Thr Gln Ala Ile Phe Tyr Arg Arg Thr Thr Asp Ile 
                565                 570                 575     


Pro Ile Ile Val Gln Val Trp Asn Ser Arg Lys Phe Cys Asp Gln Phe 
            580                 585                 590         


Leu Gly Gln Val Thr Leu Asp Ala Asp Pro Ser Asp Cys Arg Asp Leu 
        595                 600                 605             


Lys Ser Leu Tyr Leu Arg Lys Lys Gly Gly Pro Thr Ala Lys Val Lys 
    610                 615                 620                 


Gln Gly His Ile Ser Phe Lys Val Ile Ser Ser Asp Asp Leu Thr Glu 
625                 630                 635                 640 


Leu 
    


<210>  1576
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN7__Homo_sapiens__NP_055111

<400>  1576

Met Asp Ala Thr Ala Leu Glu Arg Asp Ala Val Gln Phe Ala Arg Leu 
1               5                   10                  15      


Ala Val Gln Arg Asp His Glu Gly Arg Tyr Ser Glu Ala Val Phe Tyr 
            20                  25                  30          


Tyr Lys Glu Ala Ala Gln Ala Leu Ile Tyr Ala Glu Met Ala Gly Ser 
        35                  40                  45              


Ser Leu Glu Asn Ile Gln Glu Lys Ile Thr Glu Tyr Leu Glu Arg Val 
    50                  55                  60                  


Gln Ala Leu His Ser Ala Val Gln Ser Lys Ser Ala Asp Pro Leu Lys 
65                  70                  75                  80  


Ser Lys His Gln Leu Asp Leu Glu Arg Ala His Phe Leu Val Thr Gln 
                85                  90                  95      


Ala Phe Asp Glu Asp Glu Lys Glu Asn Val Glu Asp Ala Ile Glu Leu 
            100                 105                 110         


Tyr Thr Glu Ala Val Asp Leu Cys Leu Lys Thr Ser Tyr Glu Thr Ala 
        115                 120                 125             


Asp Lys Val Leu Gln Asn Lys Leu Lys Gln Leu Ala Arg Gln Ala Leu 
    130                 135                 140                 


Asp Arg Ala Glu Ala Leu Ser Glu Pro Leu Thr Lys Pro Val Gly Lys 
145                 150                 155                 160 


Ile Ser Ser Thr Ser Val Lys Pro Lys Pro Pro Pro Val Arg Ala His 
                165                 170                 175     


Phe Pro Leu Gly Ala Asn Pro Phe Leu Glu Arg Pro Gln Ser Phe Ile 
            180                 185                 190         


Ser Pro Gln Ser Cys Asp Ala Gln Gly Gln Arg Tyr Thr Ala Glu Glu 
        195                 200                 205             


Ile Glu Val Leu Arg Thr Thr Ser Lys Ile Asn Gly Ile Glu Tyr Val 
    210                 215                 220                 


Pro Phe Met Asn Val Asp Leu Arg Glu Arg Phe Ala Tyr Pro Met Pro 
225                 230                 235                 240 


Phe Cys Asp Arg Trp Gly Lys Leu Pro Leu Ser Pro Lys Gln Lys Thr 
                245                 250                 255     


Thr Phe Ser Lys Trp Val Arg Pro Glu Asp Leu Thr Asn Asn Pro Thr 
            260                 265                 270         


Met Ile Tyr Thr Val Ser Ser Phe Ser Ile Lys Gln Thr Ile Val Ser 
        275                 280                 285             


Asp Cys Ser Phe Val Ala Ser Leu Ala Ile Ser Ala Ala Tyr Glu Arg 
    290                 295                 300                 


Arg Phe Asn Lys Lys Leu Ile Thr Gly Ile Ile Tyr Pro Gln Asn Lys 
305                 310                 315                 320 


Asp Gly Glu Pro Glu Tyr Asn Pro Cys Gly Lys Tyr Met Val Lys Leu 
                325                 330                 335     


His Leu Asn Gly Val Pro Arg Lys Val Ile Ile Asp Asp Gln Leu Pro 
            340                 345                 350         


Val Asp His Lys Gly Glu Leu Leu Cys Ser Tyr Ser Asn Asn Lys Ser 
        355                 360                 365             


Glu Leu Trp Val Ser Leu Ile Glu Lys Ala Tyr Met Lys Val Met Gly 
    370                 375                 380                 


Gly Tyr Asp Phe Pro Gly Ser Asn Ser Asn Ile Asp Leu His Ala Leu 
385                 390                 395                 400 


Thr Gly Trp Ile Pro Glu Arg Ile Ala Met His Ser Asp Ser Gln Thr 
                405                 410                 415     


Phe Ser Lys Asp Asn Ser Phe Arg Met Leu Tyr Gln Arg Phe His Lys 
            420                 425                 430         


Gly Asp Val Leu Ile Thr Ala Ser Thr Gly Met Met Thr Glu Ala Glu 
        435                 440                 445             


Gly Glu Lys Trp Gly Leu Val Pro Thr His Ala Tyr Ala Val Leu Asp 
    450                 455                 460                 


Ile Arg Glu Phe Lys Gly Leu Arg Phe Ile Gln Leu Lys Asn Pro Trp 
465                 470                 475                 480 


Ser His Leu Arg Trp Lys Gly Arg Tyr Ser Glu Asn Asp Val Lys Asn 
                485                 490                 495     


Trp Thr Pro Glu Leu Gln Lys Tyr Leu Asn Phe Asp Pro Arg Thr Ala 
            500                 505                 510         


Gln Lys Ile Asp Asn Gly Ile Phe Trp Ile Ser Trp Asp Asp Leu Cys 
        515                 520                 525             


Gln Tyr Tyr Asp Val Ile Tyr Leu Ser Trp Asn Pro Gly Leu Phe Lys 
    530                 535                 540                 


Glu Ser Thr Cys Ile His Ser Thr Trp Asp Ala Lys Gln Gly Pro Val 
545                 550                 555                 560 


Lys Asp Ala Tyr Ser Leu Ala Asn Asn Pro Gln Tyr Lys Leu Glu Val 
                565                 570                 575     


Gln Cys Pro Gln Gly Gly Ala Ala Val Trp Val Leu Leu Ser Arg His 
            580                 585                 590         


Ile Thr Asp Lys Asp Asp Phe Ala Asn Asn Arg Glu Phe Ile Thr Met 
        595                 600                 605             


Val Val Tyr Lys Thr Asp Gly Lys Lys Val Tyr Tyr Pro Ala Asp Pro 
    610                 615                 620                 


Pro Pro Tyr Ile Asp Gly Ile Arg Ile Asn Ser Pro His Tyr Leu Thr 
625                 630                 635                 640 


Lys Ile Lys Leu Thr Thr Pro Gly Thr His Thr Phe Thr Leu Val Val 
                645                 650                 655     


Ser Gln Tyr Glu Lys Gln Asn Thr Ile His Tyr Thr Val Arg Val Tyr 
            660                 665                 670         


Ser Ala Cys Ser Phe Thr Phe Ser Lys Ile Pro Ser Pro Tyr Thr Leu 
        675                 680                 685             


Ser Lys Arg Ile Asn Gly Lys Trp Ser Gly Gln Ser Ala Gly Gly Cys 
    690                 695                 700                 


Gly Asn Phe Gln Glu Thr His Lys Asn Asn Pro Ile Tyr Gln Phe His 
705                 710                 715                 720 


Ile Glu Lys Thr Gly Pro Leu Leu Ile Glu Leu Arg Gly Pro Arg Gln 
                725                 730                 735     


Tyr Ser Val Gly Phe Glu Val Val Thr Val Ser Thr Leu Gly Asp Pro 
            740                 745                 750         


Gly Pro His Gly Phe Leu Arg Lys Ser Ser Gly Asp Tyr Arg Cys Gly 
        755                 760                 765             


Phe Cys Tyr Leu Glu Leu Glu Asn Ile Pro Ser Gly Ile Phe Asn Ile 
    770                 775                 780                 


Ile Pro Ser Thr Phe Leu Pro Lys Gln Glu Gly Pro Phe Phe Leu Asp 
785                 790                 795                 800 


Phe Asn Ser Ile Ile Pro Ile Lys Ile Thr Gln Leu Gln 
                805                 810             


<210>  1577
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPN9__Homo_sapiens__NP_006606

<400>  1577

Met Pro Tyr Leu Tyr Arg Ala Pro Gly Pro Gln Ala His Pro Val Pro 
1               5                   10                  15      


Lys Asp Ala Arg Ile Thr His Ser Ser Gly Gln Ser Phe Glu Gln Met 
            20                  25                  30          


Arg Gln Glu Cys Leu Gln Arg Gly Thr Leu Phe Glu Asp Ala Asp Phe 
        35                  40                  45              


Pro Ala Ser Asn Ser Ser Leu Phe Tyr Ser Glu Arg Pro Gln Ile Pro 
    50                  55                  60                  


Phe Val Trp Lys Arg Pro Gly Glu Ile Val Lys Asn Pro Glu Phe Ile 
65                  70                  75                  80  


Leu Gly Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Glu Leu Gly Asp 
                85                  90                  95      


Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Gln Lys Ala 
            100                 105                 110         


Leu Ala Arg Val Ile Pro Gln Asp Gln Ser Phe Gly Pro Gly Tyr Ala 
        115                 120                 125             


Gly Ile Phe His Phe Gln Phe Trp Gln His Ser Glu Trp Leu Asp Val 
    130                 135                 140                 


Val Ile Asp Asp Arg Leu Pro Thr Phe Arg Asp Arg Leu Val Phe Leu 
145                 150                 155                 160 


His Ser Ala Asp His Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
                165                 170                 175     


Tyr Ala Lys Leu Asn Gly Ser Tyr Glu Ala Leu Lys Gly Gly Ser Ala 
            180                 185                 190         


Ile Glu Ala Met Glu Asp Phe Thr Gly Gly Val Ala Glu Thr Phe Gln 
        195                 200                 205             


Thr Lys Glu Ala Pro Glu Asn Phe Tyr Glu Ile Leu Glu Lys Ala Leu 
    210                 215                 220                 


Lys Arg Gly Ser Leu Leu Gly Cys Phe Ile Asp Thr Arg Ser Ala Ala 
225                 230                 235                 240 


Glu Ser Glu Ala Arg Thr Pro Phe Gly Leu Ile Lys Gly His Ala Tyr 
                245                 250                 255     


Ser Val Thr Gly Ile Asp Gln Val Ser Phe Arg Gly Gln Arg Ile Glu 
            260                 265                 270         


Leu Ile Arg Ile Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
        275                 280                 285             


Trp Ser Asp Ser Ser Pro Glu Trp Arg Ser Val Gly Pro Ala Glu Gln 
    290                 295                 300                 


Lys Arg Leu Cys His Thr Ala Leu Asp Asp Gly Glu Phe Trp Met Ala 
305                 310                 315                 320 


Phe Lys Asp Phe Lys Ala His Phe Asp Lys Val Glu Ile Cys Asn Leu 
                325                 330                 335     


Thr Pro Asp Ala Leu Glu Glu Asp Ala Ile His Lys Trp Glu Val Thr 
            340                 345                 350         


Val His Gln Gly Ser Trp Val Arg Gly Ser Thr Ala Gly Gly Cys Arg 
        355                 360                 365             


Asn Phe Leu Asp Thr Phe Trp Thr Asn Pro Gln Ile Lys Leu Ser Leu 
    370                 375                 380                 


Thr Glu Lys Asp Glu Gly Gln Glu Glu Cys Ser Phe Leu Val Ala Leu 
385                 390                 395                 400 


Met Gln Lys Asp Arg Arg Lys Leu Lys Arg Phe Gly Ala Asn Val Leu 
                405                 410                 415     


Thr Ile Gly Tyr Ala Ile Tyr Glu Cys Pro Asp Lys Asp Glu His Leu 
            420                 425                 430         


Asn Lys Asp Phe Phe Arg Tyr His Ala Ser Arg Ala Arg Ser Lys Thr 
        435                 440                 445             


Phe Ile Asn Leu Arg Glu Val Ser Asp Arg Phe Lys Leu Pro Pro Gly 
    450                 455                 460                 


Glu Tyr Ile Leu Ile Pro Ser Thr Phe Glu Pro His Gln Glu Ala Asp 
465                 470                 475                 480 


Phe Cys Leu Arg Ile Phe Ser Glu Lys Lys Ala Ile Thr Arg Asp Met 
                485                 490                 495     


Asp Gly Asn Val Asp Ile Asp Leu Pro Glu Pro Pro Lys Pro Thr Pro 
            500                 505                 510         


Pro Asp Gln Glu Thr Glu Glu Glu Gln Arg Phe Arg Ala Leu Phe Glu 
        515                 520                 525             


Gln Val Ala Gly Glu Asp Met Glu Val Thr Ala Glu Glu Leu Glu Tyr 
    530                 535                 540                 


Val Leu Asn Ala Val Leu Gln Lys Lys Lys Asp Ile Lys Phe Lys Lys 
545                 550                 555                 560 


Leu Ser Leu Ile Ser Cys Lys Asn Ile Ile Ser Leu Met Asp Thr Ser 
                565                 570                 575     


Gly Asn Gly Lys Leu Glu Phe Asp Glu Phe Lys Val Phe Trp Asp Lys 
            580                 585                 590         


Leu Lys Gln Trp Ile Asn Leu Phe Leu Arg Phe Asp Ala Asp Lys Ser 
        595                 600                 605             


Gly Thr Met Ser Thr Tyr Glu Leu Arg Thr Ala Leu Lys Ala Ala Gly 
    610                 615                 620                 


Phe Gln Leu Ser Ser His Leu Leu Gln Leu Ile Val Leu Arg Tyr Ala 
625                 630                 635                 640 


Asp Glu Glu Leu Gln Leu Asp Phe Asp Asp Phe Leu Asn Cys Leu Val 
                645                 650                 655     


Arg Leu Glu Asn Ala Ser Arg Val Phe Gln Ala Leu Ser Thr Lys Asn 
            660                 665                 670         


Lys Glu Phe Ile His Leu Asn Ile Asn Glu Phe Ile His Leu Thr Met 
        675                 680                 685             


Asn Ile 
    690 


<210>  1578
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPNS1__Homo_sapiens__NP_001289561

<400>  1578

Met Phe Leu Val Asn Ser Phe Leu Lys Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Leu Gly Gly Gly Leu Gly Asn Val Leu Gly Gly Leu 
            20                  25                  30          


Ile Ser Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Thr Ala Met Arg Ile Leu Gly Gly 
    50                  55                  60                  


Val Ile Ser Ala Ile Ser Glu Ala Ala Ala Gln Tyr Asn Pro Glu Pro 
65                  70                  75                  80  


Pro Pro Pro Arg Thr His Tyr Ser Asn Ile Glu Ala Asn Glu Ser Glu 
                85                  90                  95      


Glu Val Arg Gln Phe Arg Arg Leu Phe Ala Gln Leu Ala Gly Asp Asp 
            100                 105                 110         


Met Glu Val Ser Ala Thr Glu Leu Met Asn Ile Leu Asn Lys Val Val 
        115                 120                 125             


Thr Arg His Pro Asp Leu Lys Thr Asp Gly Phe Gly Ile Asp Thr Cys 
    130                 135                 140                 


Arg Ser Met Val Ala Val Met Asp Ser Asp Thr Thr Gly Lys Leu Gly 
145                 150                 155                 160 


Phe Glu Glu Phe Lys Tyr Leu Trp Asn Asn Ile Lys Arg Trp Gln Ala 
                165                 170                 175     


Ile Tyr Lys Gln Phe Asp Thr Asp Arg Ser Gly Thr Ile Cys Ser Ser 
            180                 185                 190         


Glu Leu Pro Gly Ala Phe Glu Ala Ala Gly Phe His Leu Asn Glu His 
        195                 200                 205             


Leu Tyr Asn Met Ile Ile Arg Arg Tyr Ser Asp Glu Ser Gly Asn Met 
    210                 215                 220                 


Asp Phe Asp Asn Phe Ile Ser Cys Leu Val Arg Leu Asp Ala Met Phe 
225                 230                 235                 240 


Arg Ala Phe Lys Ser Leu Asp Lys Asp Gly Thr Gly Gln Ile Gln Val 
                245                 250                 255     


Asn Ile Gln Glu Trp Leu Gln Leu Thr Met Tyr Ser 
            260                 265             


<210>  1579
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPRIN1__Homo_sapiens__NP_005889

<400>  1579

Met Pro Ser Ala Thr Ser His Ser Gly Ser Gly Ser Lys Ser Ser Gly 
1               5                   10                  15      


Pro Pro Pro Pro Ser Gly Ser Ser Gly Ser Glu Ala Ala Ala Gly Ala 
            20                  25                  30          


Gly Ala Ala Ala Pro Ala Ser Gln His Pro Ala Thr Gly Thr Gly Ala 
        35                  40                  45              


Val Gln Thr Glu Ala Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys 
    50                  55                  60                  


Leu Arg Asn Leu Glu Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu 
65                  70                  75                  80  


Arg Met Asn Lys Gly Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val 
                85                  90                  95      


Ser Lys Tyr Gln Glu Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu 
            100                 105                 110         


Gln Arg Ser Phe Met Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys 
        115                 120                 125             


Lys Thr Ala Arg Arg Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys 
    130                 135                 140                 


Arg Leu Lys Thr Val Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly 
145                 150                 155                 160 


Asp Asp Glu Val Arg Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro 
                165                 170                 175     


Ile Leu Ser Glu Glu Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu 
            180                 185                 190         


Val Asp Pro Glu Arg Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu 
        195                 200                 205             


His Ala Ser Ile His Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro 
    210                 215                 220                 


Val Cys Gly Thr Thr Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val 
225                 230                 235                 240 


Phe Gln Ser Asn Tyr Phe Asp Ser Thr His Asn His Gln Asn Gly Leu 
                245                 250                 255     


Cys Glu Glu Glu Glu Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val 
            260                 265                 270         


Pro Glu Ala Glu Pro Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu 
        275                 280                 285             


Val Glu Ser Thr Glu Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln 
    290                 295                 300                 


Phe Thr Ser Gly Glu Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr 
305                 310                 315                 320 


Val Glu Val Val Asn Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro 
                325                 330                 335     


Ser Val Pro Glu Pro His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro 
            340                 345                 350         


Leu Val Arg Arg Gln Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly 
        355                 360                 365             


Pro Tyr Asn Phe Ile Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr 
    370                 375                 380                 


Leu Asp Pro Ala Ile Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn 
385                 390                 395                 400 


Met Asp Met Pro Gln Leu Val Cys Pro Pro Val His Ser Glu Ser Arg 
                405                 410                 415     


Leu Ala Gln Pro Asn Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val 
            420                 425                 430         


Pro Leu Val Ser Ser Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu 
        435                 440                 445             


Tyr Gln Pro Ser His Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile 
    450                 455                 460                 


Asp Gln Ile Gln Ala Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala 
465                 470                 475                 480 


Ser Ser Ser Leu Pro Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly 
                485                 490                 495     


Thr Ser Lys Pro Leu His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro 
            500                 505                 510         


Phe Gln Ser Met Gln Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro 
        515                 520                 525             


Val Asn Glu Pro Glu Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser 
    530                 535                 540                 


Tyr Asn Gln Ser Phe Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu 
545                 550                 555                 560 


Leu Gln Gln Glu Gln Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser 
                565                 570                 575     


Pro Asp Gln Ser His Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln 
            580                 585                 590         


Gln Asn Thr Gly Phe Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg 
        595                 600                 605             


Gly Val Ser Arg Gly Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly 
    610                 615                 620                 


Tyr Arg Gly Pro Ala Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg 
625                 630                 635                 640 


Pro Ser Phe Ser Asn Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe 
                645                 650                 655     


Ser Ala Pro Arg Asp Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln 
            660                 665                 670         


Asn Phe Lys Arg Gly Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg 
        675                 680                 685             


Gly Arg Gly Gly Pro Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn 
    690                 695                 700                 


Thr Gln Gln Val Asn 
705                 


<210>  1580
<211>  1127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPRIN2__Homo_sapiens__NP_001002259

<400>  1580

Met Glu Val Gln Val Ser Gln Ala Ser Leu Gly Phe Glu Leu Thr Ser 
1               5                   10                  15      


Val Glu Lys Ser Leu Arg Glu Trp Ser Arg Leu Ser Arg Glu Val Ile 
            20                  25                  30          


Ala Trp Leu Cys Pro Ser Ser Pro Asn Phe Ile Leu Asn Phe Pro Pro 
        35                  40                  45              


Pro Pro Ser Ala Ser Ser Val Ser Met Val Gln Leu Phe Ser Ser Pro 
    50                  55                  60                  


Phe Gly Tyr Gln Ser Pro Ser Gly His Ser Glu Glu Glu Arg Glu Gly 
65                  70                  75                  80  


Asn Met Lys Ser Ala Lys Pro Gln Val Asn His Ser Gln His Gly Glu 
                85                  90                  95      


Ser Gln Arg Ala Leu Ser Pro Leu Gln Ser Thr Leu Ser Ser Ala Ala 
            100                 105                 110         


Ser Pro Ser Gln Ala Tyr Glu Thr Tyr Ile Glu Asn Gly Leu Ile Cys 
        115                 120                 125             


Leu Lys His Lys Ile Arg Asn Ile Glu Lys Lys Lys Leu Lys Leu Glu 
    130                 135                 140                 


Asp Tyr Lys Asp Arg Leu Lys Ser Gly Glu His Leu Asn Pro Asp Gln 
145                 150                 155                 160 


Leu Glu Ala Val Glu Lys Tyr Glu Glu Val Leu His Asn Leu Glu Phe 
                165                 170                 175     


Ala Lys Glu Leu Gln Lys Thr Phe Ser Gly Leu Ser Leu Asp Leu Leu 
            180                 185                 190         


Lys Ala Gln Lys Lys Ala Gln Arg Arg Glu His Met Leu Lys Leu Glu 
        195                 200                 205             


Ala Glu Lys Lys Lys Leu Arg Thr Ile Leu Gln Val Gln Tyr Val Leu 
    210                 215                 220                 


Gln Asn Leu Thr Gln Glu His Val Gln Lys Asp Phe Lys Gly Gly Leu 
225                 230                 235                 240 


Asn Gly Ala Val Tyr Leu Pro Ser Lys Glu Leu Asp Tyr Leu Ile Lys 
                245                 250                 255     


Phe Ser Lys Leu Thr Cys Pro Glu Arg Asn Glu Ser Leu Ser Val Glu 
            260                 265                 270         


Asp Gln Met Glu Gln Ser Ser Leu Tyr Phe Trp Asp Leu Leu Glu Gly 
        275                 280                 285             


Ser Glu Lys Ala Val Val Gly Thr Thr Tyr Lys His Leu Lys Asp Leu 
    290                 295                 300                 


Leu Ser Lys Leu Leu Asn Ser Gly Tyr Phe Glu Ser Ile Pro Val Pro 
305                 310                 315                 320 


Lys Asn Ala Lys Glu Lys Glu Val Pro Leu Glu Glu Glu Met Leu Ile 
                325                 330                 335     


Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu 
            340                 345                 350         


Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu 
        355                 360                 365             


Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln 
    370                 375                 380                 


Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu 
385                 390                 395                 400 


Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys 
                405                 410                 415     


Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val 
            420                 425                 430         


Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys 
        435                 440                 445             


Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys 
    450                 455                 460                 


Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys 
465                 470                 475                 480 


Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu 
                485                 490                 495     


Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro 
            500                 505                 510         


Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser 
        515                 520                 525             


Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr 
    530                 535                 540                 


Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr 
545                 550                 555                 560 


Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser 
                565                 570                 575     


Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro 
            580                 585                 590         


Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser Ser Ser Thr 
        595                 600                 605             


Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met 
    610                 615                 620                 


Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp 
625                 630                 635                 640 


Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala 
                645                 650                 655     


Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln 
            660                 665                 670         


Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Thr Ser Ser Pro Val Thr 
        675                 680                 685             


Cys Ser Ser Asn Ala Cys Leu Val Thr Thr Asp Gln Ala Ser Ser Gly 
    690                 695                 700                 


Ser Glu Thr Glu Phe Met Thr Ser Glu Thr Pro Glu Ala Ala Ile Pro 
705                 710                 715                 720 


Pro Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala 
                725                 730                 735     


Lys Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser 
            740                 745                 750         


Val Thr Ile Asn Thr Ala Pro Phe Gln Ala Met Gln Thr Val Phe Asn 
        755                 760                 765             


Val Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser 
    770                 775                 780                 


Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln 
785                 790                 795                 800 


Thr Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Thr Val 
                805                 810                 815     


His Ser Gln Glu Thr Ala Ala Asn Tyr His Pro Asp Gly Thr Ile Gln 
            820                 825                 830         


Val Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Thr Asn Val Phe 
        835                 840                 845             


Pro Arg Pro Thr Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg Gly 
    850                 855                 860                 


Cys Thr Arg Gly Gly Arg Leu Ile Thr Asn Ser Tyr Arg Ser Pro Gly 
865                 870                 875                 880 


Gly Tyr Lys Gly Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile Ser Asn 
                885                 890                 895     


Gly Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala 
            900                 905                 910         


Pro Tyr Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg Gly Gly 
        915                 920                 925             


Thr Ser Gly Gly Pro Arg Ala Asn Ser Arg Ala Gly Trp Ser Asp Ser 
    930                 935                 940                 


Ser Gln Val Ser Ser Pro Glu Arg Asp Asn Glu Thr Phe Asn Ser Gly 
945                 950                 955                 960 


Asp Ser Gly Gln Gly Asp Ser Arg Ser Met Thr Pro Val Asp Val Pro 
                965                 970                 975     


Val Thr Asn Pro Ala Ala Thr Ile Leu Pro Val His Val Tyr Pro Leu 
            980                 985                 990         


Pro Gln Gln Met Arg Val Ala Phe  Ser Ala Ala Arg Thr  Ser Asn Leu 
        995                 1000                 1005             


Ala Pro  Gly Thr Leu Asp Gln  Pro Ile Val Phe Asp  Leu Leu Leu 
    1010                 1015                 1020             


Asn Asn  Leu Gly Glu Thr Phe  Asp Leu Gln Leu Gly  Arg Phe Asn 
    1025                 1030                 1035             


Cys Pro  Val Asn Gly Thr Tyr  Val Phe Ile Phe His  Met Leu Lys 
    1040                 1045                 1050             


Leu Ala  Val Asn Val Pro Leu  Tyr Val Asn Leu Met  Lys Asn Glu 
    1055                 1060                 1065             


Glu Val  Leu Val Ser Ala Tyr  Ala Asn Asp Gly Ala  Pro Asp His 
    1070                 1075                 1080             


Glu Thr  Ala Ser Asn His Ala  Ile Leu Gln Leu Phe  Gln Gly Asp 
    1085                 1090                 1095             


Gln Ile  Trp Leu Arg Leu His  Arg Gly Ala Ile Tyr  Gly Ser Ser 
    1100                 1105                 1110             


Trp Lys  Tyr Ser Thr Phe Ser  Gly Tyr Leu Leu Tyr  Gln Asp 
    1115                 1120                 1125         


<210>  1581
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPS2__Homo_sapiens__NP_001273476

<400>  1581

Met Ile Asn Thr Gly Thr Gln Met Asp Leu Glu Val Lys Gly Val Ala 
1               5                   10                  15      


Ala Thr Ser Arg Ser Gln Ile Gln Pro Phe Phe Gly Arg Lys Lys Pro 
            20                  25                  30          


Leu Gln Gln Arg Trp Thr Ser Glu Ser Trp Thr Asn Gln Asn Ser Cys 
        35                  40                  45              


Pro Pro Val Val Pro Arg Leu Asp Leu Gly Ser Leu Val Asp Ser Asp 
    50                  55                  60                  


Asp Glu Asp Gln Asn Ile Ile Pro Glu Asn Leu Pro Ala Pro Thr Asp 
65                  70                  75                  80  


Lys Cys Lys Leu Lys Tyr Gln Gln Cys Lys Thr Glu Ile Lys Glu Gly 
                85                  90                  95      


Tyr Lys Gln Tyr Ser Gln Arg Asn Ala Glu Asn Thr Lys Ser Asn Val 
            100                 105                 110         


Thr His Lys Gln Ser Pro Arg Asn Lys Ile Asp Glu Lys Cys Val Gln 
        115                 120                 125             


Asp Glu Glu Ala Asn Thr Asp Asp Leu Thr Thr Leu Asp Arg Lys Ala 
    130                 135                 140                 


Ile Leu Gln Gln Gly Tyr Ala Asp Asn Ser Cys Asp Lys Gln Gln Arg 
145                 150                 155                 160 


Ala Arg Lys Leu Asp Ala Glu Ile Val Ala Ala Glu Lys Lys Lys Gln 
                165                 170                 175     


Ile Val Ala Glu Gln Val Met Ile Asp His Leu Ser Arg Ala Val Ile 
            180                 185                 190         


Ser Asp Pro Glu Gln Asn Leu Ala Ile Glu Gln Lys Glu Ser Asp His 
        195                 200                 205             


Ile Leu Pro Asp Ser Lys Met Thr Pro Leu Arg Phe Arg Lys Arg Thr 
    210                 215                 220                 


Leu His Glu Thr Lys Ile Arg Thr His Ser Thr Leu Thr Glu Asn Val 
225                 230                 235                 240 


Leu Ser His Lys Leu Gln Phe Asp Gly Arg Ile Val Ser Arg Thr Asn 
                245                 250                 255     


Val Leu Pro Phe Ile Gln Lys Ser Ile Tyr Ser His Gln Cys Gly Arg 
            260                 265                 270         


Arg Lys Gly Lys Gln Tyr Arg Leu Gly Asp Phe Tyr Val Gly Ala Thr 
        275                 280                 285             


Leu Thr Phe Leu Ser Ser Asp His Leu Ser Leu Pro Glu Ser Ile Lys 
    290                 295                 300                 


Glu Asn Thr Leu Leu Lys Leu Arg Ile Thr Asn Ile Asp Gln Ile Ala 
305                 310                 315                 320 


Leu Asp Ser Leu Lys Thr Ala Ser Met Glu Gln Glu Asp Asp Ile Ile 
                325                 330                 335     


Ile Gln Glu Thr Asn Asp Arg Leu Val Phe Lys Ala Ile Gln Asp Val 
            340                 345                 350         


Leu Lys Glu Lys Leu His Lys Arg Gly Val Arg Ile Leu Thr Gly Leu 
        355                 360                 365             


Gly Lys Tyr Phe Gln Gln Leu Asp Lys Glu Gly Asn Gly Leu Leu Asp 
    370                 375                 380                 


Lys Ala Asp Phe Lys Gln Ala Leu Lys Val Phe His Leu Glu Val Ser 
385                 390                 395                 400 


Glu Lys Asp Phe Glu Ser Ala Trp Leu Ile Leu Asn Asp Asn Gly Asn 
                405                 410                 415     


Gly Lys Val Asp Tyr Gly Glu Phe Lys Arg Gly Ile Ile Gly Glu Met 
            420                 425                 430         


Asn Glu Tyr Arg Lys Ser Tyr Val Arg Lys Ala Phe Met Lys Leu Asp 
        435                 440                 445             


Phe Asn Lys Ser Gly Ser Val Pro Ile Ile Asn Ile Arg Lys Cys Tyr 
    450                 455                 460                 


Cys Ala Lys Lys His Ser Gln Val Ile Ser Gly 
465                 470                 475 


<210>  1582
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPS__Homo_sapiens__NP_004049

<400>  1582

Met Gln Cys His Arg Asp Leu Ala Leu Ser Gln Ala Leu Trp Gly Trp 
1               5                   10                  15      


Gln Leu Ser Lys Gln Ser Gly Trp Ala His Pro Ser Leu Pro His Ser 
            20                  25                  30          


Pro Leu Pro Ser Thr Val His Ser Cys Ser Trp Ala Pro Pro His Leu 
        35                  40                  45              


Gln Arg His Leu Pro Leu Ala Thr Val Ser Pro Gly Thr Thr Gln Leu 
    50                  55                  60                  


Thr Gln Gly Pro Ala Gly Arg Thr Leu Gly Gln Thr Gln Ala Ser Cys 
65                  70                  75                  80  


Pro Glu Pro Arg Pro Ser Met Asp Ala Val Asp Ala Thr Met Glu Lys 
                85                  90                  95      


Leu Arg Ala Gln Cys Leu Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu 
            100                 105                 110         


Ala Arg Phe Phe Arg Gln Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp 
        115                 120                 125             


Ala Asp Glu Phe Arg Gln Gly Leu Ala Lys Leu Gly Leu Val Leu Asp 
    130                 135                 140                 


Gln Ala Glu Ala Glu Gly Val Cys Arg Lys Trp Asp Arg Asn Gly Ser 
145                 150                 155                 160 


Gly Thr Leu Asp Leu Glu Glu Phe Leu Arg Ala Leu Arg Pro Pro Met 
                165                 170                 175     


Ser Gln Ala Arg Glu Ala Val Ile Ala Ala Ala Phe Ala Lys Leu Asp 
            180                 185                 190         


Arg Ser Gly Asp Gly Val Val Thr Val Asp Asp Leu Arg Gly Val Tyr 
        195                 200                 205             


Ser Gly Arg Ala His Pro Lys Val Arg Ser Gly Glu Trp Thr Glu Asp 
    210                 215                 220                 


Glu Val Leu Arg Arg Phe Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp 
225                 230                 235                 240 


Gly Gln Val Thr Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser 
                245                 250                 255     


Ala Ser Met Asn Thr Asp Glu Glu Phe Val Ala Met Met Thr Ser Ala 
            260                 265                 270         


Trp Gln Leu 
        275 


<210>  1583
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPSL__Homo_sapiens__NP_001036090

<400>  1583

Met Ala Gly Thr Ala Arg His Asp Arg Glu Met Ala Ile Gln Ala Lys 
1               5                   10                  15      


Lys Lys Leu Thr Thr Ala Thr Asp Pro Ile Glu Arg Leu Arg Leu Gln 
            20                  25                  30          


Cys Leu Ala Arg Gly Ser Ala Gly Ile Lys Gly Leu Gly Arg Val Phe 
        35                  40                  45              


Arg Ile Met Asp Asp Asp Asn Asn Arg Thr Leu Asp Phe Lys Glu Phe 
    50                  55                  60                  


Met Lys Gly Leu Asn Asp Tyr Ala Val Val Met Glu Lys Glu Glu Val 
65                  70                  75                  80  


Glu Glu Leu Phe Arg Arg Phe Asp Lys Asp Gly Asn Gly Thr Ile Asp 
                85                  90                  95      


Phe Asn Glu Phe Leu Leu Thr Leu Arg Pro Pro Met Ser Arg Ala Arg 
            100                 105                 110         


Lys Glu Val Ile Met Gln Ala Phe Arg Lys Leu Asp Lys Thr Gly Asp 
        115                 120                 125             


Gly Val Ile Thr Ile Glu Asp Leu Arg Glu Val Tyr Asn Ala Lys His 
    130                 135                 140                 


His Pro Lys Tyr Gln Asn Gly Glu Trp Ser Glu Glu Gln Val Phe Arg 
145                 150                 155                 160 


Lys Phe Leu Asp Asn Phe Asp Ser Pro Tyr Asp Lys Asp Gly Leu Val 
                165                 170                 175     


Thr Pro Glu Glu Phe Met Asn Tyr Tyr Ala Gly Val Ser Ala Ser Ile 
            180                 185                 190         


Asp Thr Asp Val Tyr Phe Ile Ile Met Met Arg Thr Ala Trp Lys Leu 
        195                 200                 205             


<210>  1584
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPZA2__Homo_sapiens__NP_006127

<400>  1584

Met Ala Asp Leu Glu Glu Gln Leu Ser Asp Glu Glu Lys Val Arg Ile 
1               5                   10                  15      


Ala Ala Lys Phe Ile Ile His Ala Pro Pro Gly Glu Phe Asn Glu Val 
            20                  25                  30          


Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu 
        35                  40                  45              


Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Leu Asp Gln Phe Thr Pro 
    50                  55                  60                  


Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly 
65                  70                  75                  80  


Asp Leu Gly Asn Gly Lys Phe Leu Asp Pro Lys Asn Arg Ile Cys Phe 
                85                  90                  95      


Lys Phe Asp His Leu Arg Lys Glu Ala Thr Asp Pro Arg Pro Cys Glu 
            100                 105                 110         


Val Glu Asn Ala Val Glu Ser Trp Arg Thr Ser Val Glu Thr Ala Leu 
        115                 120                 125             


Arg Ala Tyr Val Lys Glu His Tyr Pro Asn Gly Val Cys Thr Val Tyr 
    130                 135                 140                 


Gly Lys Lys Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser 
145                 150                 155                 160 


His Gln Phe Gln Ala Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu 
                165                 170                 175     


Trp Lys Phe Thr Ile Thr Pro Ser Thr Thr Gln Val Val Gly Ile Leu 
            180                 185                 190         


Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser 
        195                 200                 205             


His Lys Asp Ile Gln Asp Ser Leu Thr Val Ser Asn Glu Val Gln Thr 
    210                 215                 220                 


Ala Lys Glu Phe Ile Lys Ile Val Glu Ala Ala Glu Asn Glu Tyr Gln 
225                 230                 235                 240 


Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys 
                245                 250                 255     


Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn 
            260                 265                 270         


Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala 
        275                 280                 285     


<210>  1585
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAPZA3__Homo_sapiens__NP_201585

<400>  1585

Met Thr Leu Ser Val Leu Ser Arg Lys Asp Lys Glu Arg Val Ile Arg 
1               5                   10                  15      


Arg Leu Leu Leu Gln Ala Pro Pro Gly Glu Phe Val Asn Ala Phe Asp 
            20                  25                  30          


Asp Leu Cys Leu Leu Ile Arg Asp Glu Lys Leu Met His His Gln Gly 
        35                  40                  45              


Glu Cys Ala Gly His Gln His Cys Gln Lys Tyr Ser Val Pro Leu Cys 
    50                  55                  60                  


Ile Asp Gly Asn Pro Val Leu Leu Ser His His Asn Val Met Gly Asp 
65                  70                  75                  80  


Tyr Arg Phe Phe Asp His Gln Ser Lys Leu Ser Phe Lys Tyr Asp Leu 
                85                  90                  95      


Leu Gln Asn Gln Leu Lys Asp Ile Gln Ser His Gly Ile Ile Gln Asn 
            100                 105                 110         


Glu Ala Glu Tyr Leu Arg Val Val Leu Leu Cys Ala Leu Lys Leu Tyr 
        115                 120                 125             


Val Asn Asp His Tyr Pro Lys Gly Asn Cys Asn Met Leu Arg Lys Thr 
    130                 135                 140                 


Val Lys Ser Lys Glu Tyr Leu Ile Ala Cys Ile Glu Asp His Asn Tyr 
145                 150                 155                 160 


Glu Thr Gly Glu Cys Trp Asn Gly Leu Trp Lys Ser Lys Trp Ile Phe 
                165                 170                 175     


Gln Val Asn Pro Phe Leu Thr Gln Val Thr Gly Arg Ile Phe Val Gln 
            180                 185                 190         


Ala His Phe Phe Arg Cys Val Asn Leu His Ile Glu Ile Ser Lys Asp 
        195                 200                 205             


Leu Lys Glu Ser Leu Glu Ile Val Asn Gln Ala Gln Leu Ala Leu Ser 
    210                 215                 220                 


Phe Ala Arg Leu Val Glu Glu Gln Glu Asn Lys Phe Gln Ala Ala Val 
225                 230                 235                 240 


Leu Glu Glu Leu Gln Glu Leu Ser Asn Glu Ala Leu Arg Lys Ile Leu 
                245                 250                 255     


Arg Arg Asp Leu Pro Val Thr Arg Thr Leu Ile Asp Trp His Arg Ile 
            260                 265                 270         


Leu Ser Asp Leu Asn Leu Val Met Tyr Pro Lys Leu Gly Tyr Val Ile 
        275                 280                 285             


Tyr Ser Arg Ser Val Leu Cys Asn Trp Ile Ile 
    290                 295                 


<210>  1586
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARD10__Homo_sapiens__NP_055365

<400>  1586

Met Pro Gly Arg Ala Glu Ala Gly Glu Ala Glu Glu Glu Ala Gly Ala 
1               5                   10                  15      


Gly Ser Gly Ser Glu Ala Glu Glu Asp Ala Leu Trp Glu Arg Ile Glu 
            20                  25                  30          


Gly Val Arg His Arg Leu Ala Arg Ala Leu Asn Pro Ala Lys Leu Thr 
        35                  40                  45              


Pro Tyr Leu Arg Gln Cys Arg Val Ile Asp Glu Gln Asp Glu Glu Glu 
    50                  55                  60                  


Val Leu Ser Thr Tyr Arg Phe Pro Cys Arg Val Asn Arg Thr Gly Arg 
65                  70                  75                  80  


Leu Met Asp Ile Leu Arg Cys Arg Gly Lys Arg Gly Tyr Glu Ala Phe 
                85                  90                  95      


Leu Glu Ala Leu Glu Phe Tyr Tyr Pro Glu His Phe Thr Leu Leu Thr 
            100                 105                 110         


Gly Gln Glu Pro Ala Gln Arg Cys Ser Met Ile Leu Asp Glu Glu Gly 
        115                 120                 125             


Pro Glu Gly Leu Thr Gln Phe Leu Met Thr Glu Val Arg Arg Leu Arg 
    130                 135                 140                 


Glu Ala Arg Lys Ser Gln Leu Gln Arg Glu Gln Gln Leu Gln Ala Arg 
145                 150                 155                 160 


Gly Arg Val Leu Glu Glu Glu Arg Ala Gly Leu Glu Gln Arg Leu Arg 
                165                 170                 175     


Asp Gln Gln Gln Ala Gln Glu Arg Cys Gln Arg Leu Arg Glu Asp Trp 
            180                 185                 190         


Glu Ala Gly Ser Leu Glu Leu Leu Arg Leu Lys Asp Glu Asn Tyr Met 
        195                 200                 205             


Ile Ala Met Arg Leu Ala Gln Leu Ser Glu Glu Lys Asn Ser Ala Val 
    210                 215                 220                 


Leu Arg Ser Arg Asp Leu Gln Leu Ala Val Asp Gln Leu Lys Leu Lys 
225                 230                 235                 240 


Val Ser Arg Leu Glu Glu Glu Cys Ala Leu Leu Arg Arg Ala Arg Gly 
                245                 250                 255     


Pro Pro Pro Gly Ala Glu Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys 
            260                 265                 270         


Glu Pro Asp Asn Val Asp Leu Val Ser Glu Leu Arg Ala Glu Asn Gln 
        275                 280                 285             


Arg Leu Thr Ala Ser Leu Arg Glu Leu Gln Glu Gly Leu Gln Gln Glu 
    290                 295                 300                 


Ala Ser Arg Pro Gly Ala Pro Gly Ser Glu Arg Ile Leu Leu Asp Ile 
305                 310                 315                 320 


Leu Glu His Asp Trp Arg Glu Ala Gln Asp Ser Arg Gln Glu Leu Cys 
                325                 330                 335     


Gln Lys Leu His Ala Val Gln Gly Glu Leu Gln Trp Ala Glu Glu Leu 
            340                 345                 350         


Arg Asp Gln Tyr Leu Gln Glu Met Glu Asp Leu Arg Leu Lys His Arg 
        355                 360                 365             


Thr Leu Gln Lys Asp Cys Asp Leu Tyr Lys His Arg Met Ala Thr Val 
    370                 375                 380                 


Leu Ala Gln Leu Glu Glu Ile Glu Lys Glu Arg Asp Gln Ala Ile Gln 
385                 390                 395                 400 


Ser Arg Asp Arg Ile Gln Leu Gln Tyr Ser Gln Ser Leu Ile Glu Lys 
                405                 410                 415     


Asp Gln Tyr Arg Lys Gln Val Arg Gly Leu Glu Ala Glu Arg Asp Glu 
            420                 425                 430         


Leu Leu Thr Thr Leu Thr Ser Leu Glu Gly Thr Lys Ala Leu Leu Glu 
        435                 440                 445             


Val Gln Leu Gln Arg Ala Gln Gly Gly Thr Cys Leu Lys Ala Cys Ala 
    450                 455                 460                 


Ser Ser His Ser Leu Cys Ser Asn Leu Ser Ser Thr Trp Ser Leu Ser 
465                 470                 475                 480 


Glu Phe Pro Ser Pro Leu Gly Gly Pro Glu Ala Thr Gly Glu Ala Ala 
                485                 490                 495     


Val Met Gly Gly Pro Glu Pro His Asn Ser Glu Glu Ala Thr Asp Ser 
            500                 505                 510         


Glu Lys Glu Ile Asn Arg Leu Ser Ile Leu Pro Phe Pro Pro Ser Ala 
        515                 520                 525             


Gly Ser Ile Leu Arg Arg Gln Arg Glu Glu Asp Pro Ala Pro Pro Lys 
    530                 535                 540                 


Arg Ser Phe Ser Ser Met Ser Asp Ile Thr Gly Ser Val Thr Leu Lys 
545                 550                 555                 560 


Pro Trp Ser Pro Gly Leu Ser Ser Ser Ser Ser Ser Asp Ser Val Trp 
                565                 570                 575     


Pro Leu Gly Lys Pro Glu Gly Leu Leu Ala Arg Gly Cys Gly Leu Asp 
            580                 585                 590         


Phe Leu Asn Arg Ser Leu Ala Ile Arg Val Ser Gly Arg Ser Pro Pro 
        595                 600                 605             


Gly Gly Pro Glu Pro Gln Asp Lys Gly Pro Asp Gly Leu Ser Phe Tyr 
    610                 615                 620                 


Gly Asp Arg Trp Ser Gly Ala Val Val Arg Arg Val Leu Ser Gly Pro 
625                 630                 635                 640 


Gly Ser Ala Arg Met Glu Pro Arg Glu Gln Arg Val Glu Ala Ala Gly 
                645                 650                 655     


Leu Glu Gly Ala Cys Leu Glu Ala Glu Ala Gln Gln Arg Thr Leu Leu 
            660                 665                 670         


Trp Asn Gln Gly Ser Thr Leu Pro Ser Leu Met Asp Ser Lys Ala Cys 
        675                 680                 685             


Gln Ser Phe His Glu Ala Leu Glu Ala Trp Ala Lys Gly Pro Gly Ala 
    690                 695                 700                 


Glu Pro Phe Tyr Ile Arg Ala Asn Leu Thr Leu Pro Glu Arg Ala Asp 
705                 710                 715                 720 


Pro His Ala Leu Cys Val Lys Ala Gln Glu Ile Leu Arg Leu Val Asp 
                725                 730                 735     


Ser Ala Tyr Lys Arg Arg Gln Glu Trp Phe Cys Thr Arg Val Asp Pro 
            740                 745                 750         


Leu Thr Leu Arg Asp Leu Asp Arg Gly Thr Val Pro Asn Tyr Gln Arg 
        755                 760                 765             


Ala Gln Gln Leu Leu Glu Val Gln Glu Lys Cys Leu Pro Ser Ser Arg 
    770                 775                 780                 


His Arg Gly Pro Arg Ser Asn Leu Lys Lys Arg Ala Leu Asp Gln Leu 
785                 790                 795                 800 


Arg Leu Val Arg Pro Lys Pro Val Gly Ala Pro Ala Gly Asp Ser Pro 
                805                 810                 815     


Asp Gln Leu Leu Leu Glu Pro Cys Ala Glu Pro Glu Arg Ser Leu Arg 
            820                 825                 830         


Pro Tyr Ser Leu Val Arg Pro Leu Leu Val Ser Ala Leu Arg Pro Val 
        835                 840                 845             


Val Leu Leu Pro Glu Cys Leu Ala Pro Arg Leu Ile Arg Asn Leu Leu 
    850                 855                 860                 


Asp Leu Pro Ser Ser Arg Leu Asp Phe Gln Val Cys Pro Ala Glu Ser 
865                 870                 875                 880 


Leu Ser Gly Glu Glu Leu Cys Pro Ser Ser Ala Pro Gly Ala Pro Lys 
                885                 890                 895     


Ala Gln Pro Ala Thr Pro Gly Leu Gly Ser Arg Ile Arg Ala Ile Gln 
            900                 905                 910         


Glu Ser Val Gly Lys Lys His Cys Leu Leu Glu Leu Gly Ala Arg Gly 
        915                 920                 925             


Val Arg Glu Leu Val Gln Asn Glu Ile Tyr Pro Ile Val Ile His Val 
    930                 935                 940                 


Glu Val Thr Glu Lys Asn Val Arg Glu Val Arg Gly Leu Leu Gly Arg 
945                 950                 955                 960 


Pro Gly Trp Arg Asp Ser Glu Leu Leu Arg Gln Cys Arg Gly Ser Glu 
                965                 970                 975     


Gln Val Leu Trp Gly Leu Pro Cys Ser Trp Val Gln Val Pro Ala His 
            980                 985                 990         


Glu Trp Gly His Ala Glu Glu Leu  Ala Lys Val Val Arg  Gly Arg Ile 
        995                 1000                 1005             


Leu Gln  Glu Gln Ala Arg Leu  Val Trp Val Glu Cys  Gly Ser Ser 
    1010                 1015                 1020             


Arg Gly  Cys Pro Ser Ser Ser  Glu Ala 
    1025                 1030         


<210>  1587
<211>  1154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARD11__Homo_sapiens__NP_115791

<400>  1587

Met Pro Gly Gly Gly Pro Glu Met Asp Asp Tyr Met Glu Thr Leu Lys 
1               5                   10                  15      


Asp Glu Glu Asp Ala Leu Trp Glu Asn Val Glu Cys Asn Arg His Met 
            20                  25                  30          


Leu Ser Arg Tyr Ile Asn Pro Ala Lys Leu Thr Pro Tyr Leu Arg Gln 
        35                  40                  45              


Cys Lys Val Ile Asp Glu Gln Asp Glu Asp Glu Val Leu Asn Ala Pro 
    50                  55                  60                  


Met Leu Pro Ser Lys Ile Asn Arg Ala Gly Arg Leu Leu Asp Ile Leu 
65                  70                  75                  80  


His Thr Lys Gly Gln Arg Gly Tyr Val Val Phe Leu Glu Ser Leu Glu 
                85                  90                  95      


Phe Tyr Tyr Pro Glu Leu Tyr Lys Leu Val Thr Gly Lys Glu Pro Thr 
            100                 105                 110         


Arg Arg Phe Ser Thr Ile Val Val Glu Glu Gly His Glu Gly Leu Thr 
        115                 120                 125             


His Phe Leu Met Asn Glu Val Ile Lys Leu Gln Gln Gln Met Lys Ala 
    130                 135                 140                 


Lys Asp Leu Gln Arg Cys Glu Leu Leu Ala Arg Leu Arg Gln Leu Glu 
145                 150                 155                 160 


Asp Glu Lys Lys Gln Met Thr Leu Thr Arg Val Glu Leu Leu Thr Phe 
                165                 170                 175     


Gln Glu Arg Tyr Tyr Lys Met Lys Glu Glu Arg Asp Ser Tyr Asn Asp 
            180                 185                 190         


Glu Leu Val Lys Val Lys Asp Asp Asn Tyr Asn Leu Ala Met Arg Tyr 
        195                 200                 205             


Ala Gln Leu Ser Glu Glu Lys Asn Met Ala Val Met Arg Ser Arg Asp 
    210                 215                 220                 


Leu Gln Leu Glu Ile Asp Gln Leu Lys His Arg Leu Asn Lys Met Glu 
225                 230                 235                 240 


Glu Glu Cys Lys Leu Glu Arg Asn Gln Ser Leu Lys Leu Lys Asn Asp 
                245                 250                 255     


Ile Glu Asn Arg Pro Lys Lys Glu Gln Val Leu Glu Leu Glu Arg Glu 
            260                 265                 270         


Asn Glu Met Leu Lys Thr Lys Asn Gln Glu Leu Gln Ser Ile Ile Gln 
        275                 280                 285             


Ala Gly Lys Arg Ser Leu Pro Asp Ser Asp Lys Ala Ile Leu Asp Ile 
    290                 295                 300                 


Leu Glu His Asp Arg Lys Glu Ala Leu Glu Asp Arg Gln Glu Leu Val 
305                 310                 315                 320 


Asn Arg Ile Tyr Asn Leu Gln Glu Glu Ala Arg Gln Ala Glu Glu Leu 
                325                 330                 335     


Arg Asp Lys Tyr Leu Glu Glu Lys Glu Asp Leu Glu Leu Lys Cys Ser 
            340                 345                 350         


Thr Leu Gly Lys Asp Cys Glu Met Tyr Lys His Arg Met Asn Thr Val 
        355                 360                 365             


Met Leu Gln Leu Glu Glu Val Glu Arg Glu Arg Asp Gln Ala Phe His 
    370                 375                 380                 


Ser Arg Asp Glu Ala Gln Thr Gln Tyr Ser Gln Cys Leu Ile Glu Lys 
385                 390                 395                 400 


Asp Lys Tyr Arg Lys Gln Ile Arg Glu Leu Glu Glu Lys Asn Asp Glu 
                405                 410                 415     


Met Arg Ile Glu Met Val Arg Arg Glu Ala Cys Ile Val Asn Leu Glu 
            420                 425                 430         


Ser Lys Leu Arg Arg Leu Ser Lys Asp Ser Asn Asn Leu Asp Gln Ser 
        435                 440                 445             


Leu Pro Arg Asn Leu Pro Val Thr Ile Ile Ser Gln Asp Phe Gly Asp 
    450                 455                 460                 


Ala Ser Pro Arg Thr Asn Gly Gln Glu Ala Asp Asp Ser Ser Thr Ser 
465                 470                 475                 480 


Glu Glu Ser Pro Glu Asp Ser Lys Tyr Phe Leu Pro Tyr His Pro Pro 
                485                 490                 495     


Gln Arg Arg Met Asn Leu Lys Gly Ile Gln Leu Gln Arg Ala Lys Ser 
            500                 505                 510         


Pro Ile Ser Leu Lys Arg Thr Ser Asp Phe Gln Ala Lys Gly His Glu 
        515                 520                 525             


Glu Glu Gly Thr Asp Ala Ser Pro Ser Ser Cys Gly Ser Leu Pro Ile 
    530                 535                 540                 


Thr Asn Ser Phe Thr Lys Met Gln Pro Pro Arg Ser Arg Ser Ser Ile 
545                 550                 555                 560 


Met Ser Ile Thr Ala Glu Pro Pro Gly Asn Asp Ser Ile Val Arg Arg 
                565                 570                 575     


Tyr Lys Glu Asp Ala Pro His Arg Ser Thr Val Glu Glu Asp Asn Asp 
            580                 585                 590         


Ser Gly Gly Phe Asp Ala Leu Asp Leu Asp Asp Asp Ser His Glu Arg 
        595                 600                 605             


Tyr Ser Phe Gly Pro Ser Ser Ile His Ser Ser Ser Ser Ser His Gln 
    610                 615                 620                 


Ser Glu Gly Leu Asp Ala Tyr Asp Leu Glu Gln Val Asn Leu Met Phe 
625                 630                 635                 640 


Arg Lys Phe Ser Leu Glu Arg Pro Phe Arg Pro Ser Val Thr Ser Val 
                645                 650                 655     


Gly His Val Arg Gly Pro Gly Pro Ser Val Gln His Thr Thr Leu Asn 
            660                 665                 670         


Gly Asp Ser Leu Thr Ser Gln Leu Thr Leu Leu Gly Gly Asn Ala Arg 
        675                 680                 685             


Gly Ser Phe Val His Ser Val Lys Pro Gly Ser Leu Ala Glu Lys Ala 
    690                 695                 700                 


Gly Leu Arg Glu Gly His Gln Leu Leu Leu Leu Glu Gly Cys Ile Arg 
705                 710                 715                 720 


Gly Glu Arg Gln Ser Val Pro Leu Asp Thr Cys Thr Lys Glu Glu Ala 
                725                 730                 735     


His Trp Thr Ile Gln Arg Cys Ser Gly Pro Val Thr Leu His Tyr Lys 
            740                 745                 750         


Val Asn His Glu Gly Tyr Arg Lys Leu Val Lys Asp Met Glu Asp Gly 
        755                 760                 765             


Leu Ile Thr Ser Gly Asp Ser Phe Tyr Ile Arg Leu Asn Leu Asn Ile 
    770                 775                 780                 


Ser Ser Gln Leu Asp Ala Cys Thr Met Ser Leu Lys Cys Asp Asp Val 
785                 790                 795                 800 


Val His Val Arg Asp Thr Met Tyr Gln Asp Arg His Glu Trp Leu Cys 
                805                 810                 815     


Ala Arg Val Asp Pro Phe Thr Asp His Asp Leu Asp Met Gly Thr Ile 
            820                 825                 830         


Pro Ser Tyr Ser Arg Ala Gln Gln Leu Leu Leu Val Lys Leu Gln Arg 
        835                 840                 845             


Leu Met His Arg Gly Ser Arg Glu Glu Val Asp Gly Thr His His Thr 
    850                 855                 860                 


Leu Arg Ala Leu Arg Asn Thr Leu Gln Pro Glu Glu Ala Leu Ser Thr 
865                 870                 875                 880 


Ser Asp Pro Arg Val Ser Pro Arg Leu Ser Arg Ala Ser Phe Leu Phe 
                885                 890                 895     


Gly Gln Leu Leu Gln Phe Val Ser Arg Ser Glu Asn Lys Tyr Lys Arg 
            900                 905                 910         


Met Asn Ser Asn Glu Arg Val Arg Ile Ile Ser Gly Ser Pro Leu Gly 
        915                 920                 925             


Ser Leu Ala Arg Ser Ser Leu Asp Ala Thr Lys Leu Leu Thr Glu Lys 
    930                 935                 940                 


Gln Glu Glu Leu Asp Pro Glu Ser Glu Leu Gly Lys Asn Leu Ser Leu 
945                 950                 955                 960 


Ile Pro Tyr Ser Leu Val Arg Ala Phe Tyr Cys Glu Arg Arg Arg Pro 
                965                 970                 975     


Val Leu Phe Thr Pro Thr Val Leu Ala Lys Thr Leu Val Gln Arg Leu 
            980                 985                 990         


Leu Asn Ser Gly Gly Ala Met Glu  Phe Thr Ile Cys Lys  Ser Asp Ile 
        995                 1000                 1005             


Val Thr  Arg Asp Glu Phe Leu  Arg Arg Gln Lys Thr  Glu Thr Ile 
    1010                 1015                 1020             


Ile Tyr  Ser Arg Glu Lys Asn  Pro Asn Ala Phe Glu  Cys Ile Ala 
    1025                 1030                 1035             


Pro Ala  Asn Ile Glu Ala Val  Ala Ala Lys Asn Lys  His Cys Leu 
    1040                 1045                 1050             


Leu Glu  Ala Gly Ile Gly Cys  Thr Arg Asp Leu Ile  Lys Ser Asn 
    1055                 1060                 1065             


Ile Tyr  Pro Ile Val Leu Phe  Ile Arg Val Cys Glu  Lys Asn Ile 
    1070                 1075                 1080             


Lys Arg  Phe Arg Lys Leu Leu  Pro Arg Pro Glu Thr  Glu Glu Glu 
    1085                 1090                 1095             


Phe Leu  Arg Val Cys Arg Leu  Lys Glu Lys Glu Leu  Glu Ala Leu 
    1100                 1105                 1110             


Pro Cys  Leu Tyr Ala Thr Val  Glu Pro Asp Met Trp  Gly Ser Val 
    1115                 1120                 1125             


Glu Glu  Leu Leu Arg Val Val  Lys Asp Lys Ile Gly  Glu Glu Gln 
    1130                 1135                 1140             


Arg Lys  Thr Ile Trp Val Asp  Glu Asp Gln Leu 
    1145                 1150                 


<210>  1588
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARD14__Homo_sapiens__NP_001244899

<400>  1588

Met Gly Glu Leu Cys Arg Arg Asp Ser Ala Leu Thr Ala Leu Asp Glu 
1               5                   10                  15      


Glu Thr Leu Trp Glu Met Met Glu Ser His Arg His Arg Ile Val Arg 
            20                  25                  30          


Cys Ile Cys Pro Ser Arg Leu Thr Pro Tyr Leu Arg Gln Ala Lys Val 
        35                  40                  45              


Leu Cys Gln Leu Asp Glu Glu Glu Val Leu His Ser Pro Arg Leu Thr 
    50                  55                  60                  


Asn Ser Ala Met Arg Ala Gly His Leu Leu Asp Leu Leu Lys Thr Arg 
65                  70                  75                  80  


Gly Lys Asn Gly Ala Ile Ala Phe Leu Glu Ser Leu Lys Phe His Asn 
                85                  90                  95      


Pro Asp Val Tyr Thr Leu Val Thr Gly Leu Gln Pro Asp Val Asp Phe 
            100                 105                 110         


Ser Asn Phe Ser Gly Leu Met Glu Thr Ser Lys Leu Thr Glu Cys Leu 
        115                 120                 125             


Ala Gly Ala Ile Gly Ser Leu Gln Glu Glu Leu Asn Gln Glu Lys Gly 
    130                 135                 140                 


Gln Lys Glu Val Leu Leu Arg Arg Cys Gln Gln Leu Gln Glu His Leu 
145                 150                 155                 160 


Gly Leu Ala Glu Thr Arg Ala Glu Gly Leu His Gln Leu Glu Ala Asp 
                165                 170                 175     


His Ser Arg Met Lys Arg Glu Val Ser Ala His Phe His Glu Val Leu 
            180                 185                 190         


Arg Leu Lys Asp Glu Met Leu Ser Leu Ser Leu His Tyr Ser Asn Ala 
        195                 200                 205             


Leu Gln Glu Lys Glu Leu Ala Ala Ser Arg Cys Arg Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Tyr Leu Leu Lys Gln Glu Leu Gln Arg Ala Asn Met Val Ser 
225                 230                 235                 240 


Ser Cys Glu Leu Glu Leu Gln Glu Gln Ser Leu Arg Thr Ala Ser Asp 
                245                 250                 255     


Gln Glu Ser Gly Asp Glu Glu Leu Asn Arg Leu Lys Glu Glu Asn Glu 
            260                 265                 270         


Lys Leu Arg Ser Leu Thr Phe Ser Leu Ala Glu Lys Asp Ile Leu Glu 
        275                 280                 285             


Gln Ser Leu Asp Glu Ala Arg Gly Ser Arg Gln Glu Leu Val Glu Arg 
    290                 295                 300                 


Ile His Ser Leu Arg Glu Arg Ala Val Ala Ala Glu Arg Gln Arg Glu 
305                 310                 315                 320 


Gln Tyr Trp Glu Glu Lys Glu Gln Thr Leu Leu Gln Phe Gln Lys Ser 
                325                 330                 335     


Lys Met Ala Cys Gln Leu Tyr Arg Glu Lys Val Asn Ala Leu Gln Ala 
            340                 345                 350         


Gln Val Cys Glu Leu Gln Lys Glu Arg Asp Gln Ala Tyr Ser Ala Arg 
        355                 360                 365             


Asp Ser Ala Gln Arg Glu Ile Ser Gln Ser Leu Val Glu Lys Asp Ser 
    370                 375                 380                 


Leu Arg Arg Gln Val Phe Glu Leu Thr Asp Gln Val Cys Glu Leu Arg 
385                 390                 395                 400 


Thr Gln Leu Arg Gln Leu Gln Ala Glu Pro Pro Gly Val Leu Lys Gln 
                405                 410                 415     


Glu Ala Arg Thr Arg Glu Pro Cys Pro Arg Glu Lys Gln Arg Leu Val 
            420                 425                 430         


Arg Met His Ala Ile Cys Pro Arg Asp Asp Ser Asp Cys Ser Leu Val 
        435                 440                 445             


Ser Ser Thr Glu Ser Gln Leu Leu Ser Asp Leu Ser Ala Thr Ser Ser 
    450                 455                 460                 


Arg Glu Leu Val Asp Ser Phe Arg Ser Ser Ser Pro Ala Pro Pro Ser 
465                 470                 475                 480 


Gln Gln Ser Leu Tyr Lys Arg Val Ala Glu Asp Phe Gly Glu Glu Pro 
                485                 490                 495     


Trp Ser Phe Ser Ser Cys Leu Glu Ile Pro Glu Gly Asp Pro Gly Ala 
            500                 505                 510         


Leu Pro Gly Ala Lys Ala Gly Asp Pro His Leu Asp Tyr Glu Leu Leu 
        515                 520                 525             


Asp Thr Ala Asp Leu Pro Gln Leu Glu Ser Ser Leu Gln Pro Val Ser 
    530                 535                 540                 


Pro Gly Arg Leu Asp Val Ser Glu Ser Gly Val Leu Met Arg Arg Arg 
545                 550                 555                 560 


Pro Ala Arg Arg Ile Leu Ser Gln Val Thr Met Leu Ala Phe Gln Gly 
                565                 570                 575     


Asp Ala Leu Leu Glu Gln Ile Ser Val Ile Gly Gly Asn Leu Thr Gly 
            580                 585                 590         


Ile Phe Ile His Arg Val Thr Pro Gly Ser Ala Ala Asp Gln Met Ala 
        595                 600                 605             


Leu Arg Pro Gly Thr Gln Ile Val Met Val Asp Tyr Glu Ala Ser Glu 
    610                 615                 620                 


Pro Leu Phe Lys Ala Val Leu Glu Asp Thr Thr Leu Glu Glu Ala Val 
625                 630                 635                 640 


Gly Leu Leu Arg Arg Val Asp Gly Phe Cys Cys Leu Ser Val Lys Val 
                645                 650                 655     


Asn Thr Asp Gly Tyr Lys Arg Leu Leu Gln Asp Leu Glu Ala Lys Val 
            660                 665                 670         


Ala Thr Ser Gly Asp Ser Phe Tyr Ile Arg Val Asn Leu Ala Met Glu 
        675                 680                 685             


Gly Arg Ala Lys Gly Glu Leu Gln Val His Cys Asn Glu Val Leu His 
    690                 695                 700                 


Val Thr Asp Thr Met Phe Gln Gly Cys Gly Cys Trp His Ala His Arg 
705                 710                 715                 720 


Val Asn Ser Tyr Thr Met Lys Asp Thr Ala Ala His Gly Thr Ile Pro 
                725                 730                 735     


Asn Tyr Ser Arg 
            740 


<210>  1589
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARD16__Homo_sapiens__NP_001017534

<400>  1589

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile His Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Gln Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Glu Thr Leu Gly Leu Ser Ala Ala Leu Gln Ala Val 
                85                  90                  95      


Gln Asp Asn Pro Ala Met Pro Thr Cys Ser Ser Pro Glu Gly Arg Ile 
            100                 105                 110         


Lys Leu Cys Phe Leu Glu Asp Ala Gln Arg Ile Trp Lys Gln Lys Leu 
        115                 120                 125             


Gln Arg Cys His Val Gln Asn Thr Ile Ile Lys Trp Ser Glu Arg Tyr 
    130                 135                 140                 


Thr Ser Gly Ser Phe Glu Met Gln Trp Leu Phe Leu Arg Thr Asn Phe 
145                 150                 155                 160 


Ile Glu Arg Phe Trp Arg Asn Ile Leu Leu Leu Pro Leu His Lys Gly 
                165                 170                 175     


Ser Leu Tyr Pro Arg Ile Pro Gly Leu Gly Lys Glu Leu Gln Thr Gly 
            180                 185                 190         


Thr His Lys Leu Ser 
        195         


<210>  1590
<211>  1037
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARD6__Homo_sapiens__NP_115976

<400>  1590

Met Ala Thr Glu Ser Thr Pro Ser Glu Ile Ile Glu Arg Glu Arg Lys 
1               5                   10                  15      


Lys Leu Leu Glu Ile Leu Gln His Asp Pro Asp Ser Ile Leu Asp Thr 
            20                  25                  30          


Leu Thr Ser Arg Arg Leu Ile Ser Glu Glu Glu Tyr Glu Thr Leu Glu 
        35                  40                  45              


Asn Val Thr Asp Leu Leu Lys Lys Ser Arg Lys Leu Leu Ile Leu Val 
    50                  55                  60                  


Gln Lys Lys Gly Glu Ala Thr Cys Gln His Phe Leu Lys Cys Leu Phe 
65                  70                  75                  80  


Ser Thr Phe Pro Gln Ser Ala Ala Ile Cys Gly Leu Arg His Glu Val 
                85                  90                  95      


Leu Lys His Glu Asn Thr Val Pro Pro Gln Ser Met Gly Ala Ser Ser 
            100                 105                 110         


Asn Ser Glu Asp Ala Phe Ser Pro Gly Ile Lys Gln Pro Glu Ala Pro 
        115                 120                 125             


Glu Ile Thr Val Phe Phe Ser Glu Lys Glu His Leu Asp Leu Glu Thr 
    130                 135                 140                 


Ser Glu Phe Phe Arg Asp Lys Lys Thr Ser Tyr Arg Glu Thr Ala Leu 
145                 150                 155                 160 


Ser Ala Arg Lys Asn Glu Lys Glu Tyr Asp Thr Pro Glu Val Thr Leu 
                165                 170                 175     


Ser Tyr Ser Val Glu Lys Val Gly Cys Glu Val Pro Ala Thr Ile Thr 
            180                 185                 190         


Tyr Ile Lys Asp Gly Gln Arg Tyr Glu Glu Leu Asp Asp Ser Leu Tyr 
        195                 200                 205             


Leu Gly Lys Glu Glu Tyr Leu Gly Ser Val Asp Thr Pro Glu Asp Ala 
    210                 215                 220                 


Glu Ala Thr Val Glu Glu Glu Val Tyr Asp Asp Pro Glu His Val Gly 
225                 230                 235                 240 


Tyr Asp Gly Glu Glu Asp Phe Glu Asn Ser Glu Thr Thr Glu Phe Ser 
                245                 250                 255     


Gly Glu Glu Pro Ser Tyr Glu Gly Ser Glu Thr Ser Leu Ser Leu Glu 
            260                 265                 270         


Glu Glu Gln Glu Lys Ser Ile Glu Glu Arg Lys Lys Val Phe Lys Asp 
        275                 280                 285             


Val Leu Leu Cys Leu Asn Met Asp Arg Ser Arg Lys Val Leu Pro Asp 
    290                 295                 300                 


Phe Val Lys Gln Phe Ser Leu Asp Arg Gly Cys Lys Trp Thr Pro Glu 
305                 310                 315                 320 


Ser Pro Gly Asp Leu Ala Trp Asn Phe Leu Met Lys Val Gln Ala Arg 
                325                 330                 335     


Asp Val Thr Ala Arg Asp Ser Ile Leu Ser His Lys Val Leu Asp Glu 
            340                 345                 350         


Asp Ser Lys Glu Asp Leu Leu Ala Gly Val Glu Asn Leu Glu Ile Arg 
        355                 360                 365             


Asp Ile Gln Thr Ile Asn Pro Leu Asp Val Leu Cys Ala Thr Met Leu 
    370                 375                 380                 


Cys Ser Asp Ser Ser Leu Gln Arg Gln Val Met Ser Asn Met Tyr Gln 
385                 390                 395                 400 


Cys Gln Phe Ala Leu Pro Leu Leu Leu Pro Asp Ala Glu Asn Asn Lys 
                405                 410                 415     


Ser Ile Leu Met Leu Gly Ala Met Lys Asp Ile Val Lys Lys Gln Ser 
            420                 425                 430         


Thr Gln Phe Ser Gly Gly Pro Thr Glu Asp Thr Glu Lys Phe Leu Thr 
        435                 440                 445             


Leu Met Lys Met Pro Val Ile Ser Phe Val Arg Leu Gly Tyr Cys Ser 
    450                 455                 460                 


Phe Ser Lys Ser Arg Ile Leu Asn Thr Leu Leu Ser Pro Ala Gln Leu 
465                 470                 475                 480 


Lys Leu His Lys Ile Phe Leu His Gln Asp Leu Pro Leu Leu Val Leu 
                485                 490                 495     


Pro Arg Gln Ile Ser Asp Gly Leu Val Glu Ile Thr Trp Cys Phe Pro 
            500                 505                 510         


Asp Ser Asp Asp Arg Lys Glu Asn Pro Phe Phe Gln Lys Pro Val Ala 
        515                 520                 525             


Leu Ala Asn Leu Arg Gly Asn Leu Glu Ser Phe Trp Thr Gln Phe Gly 
    530                 535                 540                 


Phe Leu Met Glu Val Ser Ser Ala Val Phe Phe Phe Thr Asp Cys Leu 
545                 550                 555                 560 


Gly Glu Lys Glu Trp Asp Leu Leu Met Phe Leu Gly Glu Ala Ala Ile 
                565                 570                 575     


Glu Arg Cys Tyr Phe Val Leu Ser Ser Gln Ala Arg Glu Ser Glu Glu 
            580                 585                 590         


Ala Gln Ile Phe Gln Arg Ile Leu Asn Leu Lys Pro Ala Gln Leu Leu 
        595                 600                 605             


Phe Trp Glu Arg Gly Asp Ala Gly Asp Arg Arg Lys Asn Met Glu Gly 
    610                 615                 620                 


Leu Gln Ala Ala Leu Gln Glu Val Met Phe Ser Ser Cys Leu Arg Cys 
625                 630                 635                 640 


Val Ser Val Glu Asp Met Ala Ala Leu Ala Arg Glu Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Glu Asp Phe Glu Asn Thr Gln Arg Ile Gln Val Ser Ser Gly 
            660                 665                 670         


Glu Asn Met Ala Gly Thr Ala Glu Gly Glu Gly Gln Gln Arg His Ser 
        675                 680                 685             


Gln Leu Lys Ser Ser Ser Lys Ser Gln Ala Leu Met Pro Ile Gln Glu 
    690                 695                 700                 


Pro Gly Thr Gln Cys Glu Leu Ser Gln Asn Leu Gln Asn Leu Tyr Gly 
705                 710                 715                 720 


Thr Pro Val Phe Arg Pro Val Leu Glu Asn Ser Trp Leu Phe Pro Thr 
                725                 730                 735     


Arg Ile Gly Gly Asn Phe Asn His Val Ser Leu Lys Ala Ser Trp Val 
            740                 745                 750         


Met Gly Arg Pro Phe Gly Ser Glu Gln Arg Pro Lys Trp Phe His Pro 
        755                 760                 765             


Leu Pro Phe Gln Asn Ala Gly Ala Gln Gly Arg Gly Lys Ser Phe Gly 
    770                 775                 780                 


Ile Gln Ser Phe His Pro Gln Ile Phe Tyr Ser Gly Glu Arg Phe Met 
785                 790                 795                 800 


Lys Phe Ser Arg Val Ala Arg Gly Cys His Ser Asn Gly Thr Phe Gly 
                805                 810                 815     


Arg Leu Pro Arg Pro Ile Cys Gln His Val Gln Ala Cys Pro Glu Arg 
            820                 825                 830         


Pro Gln Met Met Gly Thr Leu Glu Arg Ser Arg Ala Val Ala Ser Lys 
        835                 840                 845             


Ile Gly His Ser Tyr Ser Leu Asp Ser Gln Pro Ala Arg Ala Val Gly 
    850                 855                 860                 


Lys Pro Trp Pro Gln Gln Ala Cys Thr Arg Val Thr Glu Leu Thr Glu 
865                 870                 875                 880 


Ala Thr Gly Lys Leu Ile Arg Thr Ser His Ile Gly Lys Pro His Pro 
                885                 890                 895     


Gln Ser Phe Gln Pro Ala Ala Ala Thr Gln Lys Leu Arg Pro Ala Ser 
            900                 905                 910         


Gln Gln Gly Val Gln Met Lys Thr Gln Gly Gly Ala Ser Asn Pro Ala 
        915                 920                 925             


Leu Gln Ile Gly Ser His Pro Met Cys Lys Ser Ser Gln Phe Lys Ser 
    930                 935                 940                 


Asp Gln Ser Asn Pro Ser Thr Val Lys His Ser Gln Pro Lys Pro Phe 
945                 950                 955                 960 


His Ser Val Pro Ser Gln Pro Lys Ser Ser Gln Thr Lys Ser Cys Gln 
                965                 970                 975     


Ser Gln Pro Ser Gln Thr Lys Pro Ser Pro Cys Lys Ser Thr Gln Pro 
            980                 985                 990         


Lys Pro Ser Gln Pro Trp Pro Pro  Gln Ser Lys Pro Ser  Gln Pro Arg 
        995                 1000                 1005             


Pro Pro  Gln Pro Lys Ser Ser  Ser Thr Asn Pro Ser  Gln Ala Lys 
    1010                 1015                 1020             


Ala His  His Ser Lys Ala Gly  Gln Lys Arg Gly Gly  Lys His 
    1025                 1030                 1035         


<210>  1591
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARD8__Homo_sapiens__NP_001171829

<400>  1591

Met Glu Lys Lys Glu Cys Pro Glu Lys Ser Ser Ser Ser Glu Glu Glu 
1               5                   10                  15      


Leu Pro Arg Arg Asp Ser Gly Ser Ser Arg Asn Ile Asp Ala Ser Lys 
            20                  25                  30          


Leu Ile Arg Leu Gln Gly Ser Arg Lys Leu Leu Val Asp Asn Ser Ile 
        35                  40                  45              


Arg Glu Leu Gln Tyr Thr Lys Thr Gly Ile Phe Phe Gln Ala Glu Ala 
    50                  55                  60                  


Cys Val Thr Asn Asp Thr Val Tyr Arg Glu Leu Pro Cys Val Ser Glu 
65                  70                  75                  80  


Thr Leu Cys Asp Ile Ser His Phe Phe Gln Glu Asp Asp Glu Thr Glu 
                85                  90                  95      


Ala Glu Pro Leu Leu Phe Arg Ala Val Pro Glu Cys Gln Leu Ser Gly 
            100                 105                 110         


Gly Asp Ile Pro Ser Val Ser Glu Glu Gln Glu Ser Ser Glu Gly Gln 
        115                 120                 125             


Asp Ser Gly Asp Ile Cys Ser Glu Glu Asn Gln Ile Val Ser Ser Tyr 
    130                 135                 140                 


Ala Ser Lys Val Cys Phe Glu Ile Glu Glu Asp Tyr Lys Asn Arg Gln 
145                 150                 155                 160 


Phe Leu Gly Pro Glu Gly Asn Val Asp Val Glu Leu Ile Asp Lys Ser 
                165                 170                 175     


Thr Asn Arg Tyr Ser Val Trp Phe Pro Thr Ala Gly Trp Tyr Leu Trp 
            180                 185                 190         


Ser Ala Thr Gly Leu Gly Phe Leu Val Arg Asp Glu Val Thr Val Thr 
        195                 200                 205             


Ile Ala Phe Gly Ser Trp Ser Gln His Leu Ala Leu Asp Leu Gln His 
    210                 215                 220                 


His Glu Gln Trp Leu Val Gly Gly Pro Leu Phe Asp Val Thr Ala Glu 
225                 230                 235                 240 


Pro Glu Glu Ala Val Ala Glu Ile His Leu Pro His Phe Ile Ser Leu 
                245                 250                 255     


Gln Ala Gly Glu Val Asp Val Ser Trp Phe Leu Val Ala His Phe Lys 
            260                 265                 270         


Asn Glu Gly Met Val Leu Glu His Pro Ala Arg Val Glu Pro Phe Tyr 
        275                 280                 285             


Ala Val Leu Glu Ser Pro Ser Phe Ser Leu Met Gly Ile Leu Leu Arg 
    290                 295                 300                 


Ile Ala Ser Gly Thr Arg Leu Ser Ile Pro Ile Thr Ser Asn Thr Leu 
305                 310                 315                 320 


Ile Tyr Tyr His Pro His Pro Glu Asp Ile Lys Phe His Leu Tyr Leu 
                325                 330                 335     


Val Pro Ser Asp Ala Leu Leu Thr Lys Ala Ile Asp Asp Glu Glu Asp 
            340                 345                 350         


Arg Phe His Gly Val Arg Leu Gln Thr Ser Pro Pro Met Glu Pro Leu 
        355                 360                 365             


Asn Phe Gly Ser Ser Tyr Ile Val Ser Asn Ser Ala Asn Leu Lys Val 
    370                 375                 380                 


Met Pro Lys Glu Leu Lys Leu Ser Tyr Arg Ser Pro Gly Glu Ile Gln 
385                 390                 395                 400 


His Phe Ser Lys Phe Tyr Ala Gly Gln Met Lys Glu Pro Ile Gln Leu 
                405                 410                 415     


Glu Ile Thr Glu Lys Arg His Gly Thr Leu Val Trp Asp Thr Glu Val 
            420                 425                 430         


Lys Pro Val Asp Leu Gln Leu Val Ala Ala Ser Ala Pro Pro Pro Phe 
        435                 440                 445             


Ser Gly Ala Ala Phe Val Lys Glu Asn His Arg Gln Leu Gln Ala Arg 
    450                 455                 460                 


Met Gly Asp Leu Lys Gly Val Leu Asp Asp Leu Gln Asp Asn Glu Val 
465                 470                 475                 480 


Leu Thr Glu Asn Glu Lys Glu Leu Val Glu Gln Glu Lys Thr Arg Gln 
                485                 490                 495     


Ser Lys Asn Glu Ala Leu Leu Ser Met Val Glu Lys Lys Gly Asp Leu 
            500                 505                 510         


Ala Leu Asp Val Leu Phe Arg Ser Ile Ser Glu Arg Asp Pro Tyr Leu 
        515                 520                 525             


Val Ser Tyr Leu Arg Gln Gln Asn Leu 
    530                 535         


<210>  1592
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARD9__Homo_sapiens__NP_434700

<400>  1592

Met Ser Asp Tyr Glu Asn Asp Asp Glu Cys Trp Ser Val Leu Glu Gly 
1               5                   10                  15      


Phe Arg Val Thr Leu Thr Ser Val Ile Asp Pro Ser Arg Ile Thr Pro 
            20                  25                  30          


Tyr Leu Arg Gln Cys Lys Val Leu Asn Pro Asp Asp Glu Glu Gln Val 
        35                  40                  45              


Leu Ser Asp Pro Asn Leu Val Ile Arg Lys Arg Lys Val Gly Val Leu 
    50                  55                  60                  


Leu Asp Ile Leu Gln Arg Thr Gly His Lys Gly Tyr Val Ala Phe Leu 
65                  70                  75                  80  


Glu Ser Leu Glu Leu Tyr Tyr Pro Gln Leu Tyr Lys Lys Val Thr Gly 
                85                  90                  95      


Lys Glu Pro Ala Arg Val Phe Ser Met Ile Ile Asp Ala Ser Gly Glu 
            100                 105                 110         


Ser Gly Leu Thr Gln Leu Leu Met Thr Glu Val Met Lys Leu Gln Lys 
        115                 120                 125             


Lys Val Gln Asp Leu Thr Ala Leu Leu Ser Ser Lys Asp Asp Phe Ile 
    130                 135                 140                 


Lys Glu Leu Arg Val Lys Asp Ser Leu Leu Arg Lys His Gln Glu Arg 
145                 150                 155                 160 


Val Gln Arg Leu Lys Glu Glu Cys Glu Ala Gly Ser Arg Glu Leu Lys 
                165                 170                 175     


Arg Cys Lys Glu Glu Asn Tyr Asp Leu Ala Met Arg Leu Ala His Gln 
            180                 185                 190         


Ser Glu Glu Lys Gly Ala Ala Leu Met Arg Asn Arg Asp Leu Gln Leu 
        195                 200                 205             


Glu Ile Asp Gln Leu Lys His Ser Leu Met Lys Ala Glu Asp Asp Cys 
    210                 215                 220                 


Lys Val Glu Arg Lys His Thr Leu Lys Leu Arg His Ala Met Glu Gln 
225                 230                 235                 240 


Arg Pro Ser Gln Glu Leu Leu Trp Glu Leu Gln Gln Glu Lys Ala Leu 
                245                 250                 255     


Leu Gln Ala Arg Val Gln Glu Leu Glu Ala Ser Val Gln Glu Gly Lys 
            260                 265                 270         


Leu Asp Arg Ser Ser Pro Tyr Ile Gln Val Leu Glu Glu Asp Trp Arg 
        275                 280                 285             


Gln Ala Leu Arg Asp His Gln Glu Gln Ala Asn Thr Ile Phe Ser Leu 
    290                 295                 300                 


Arg Lys Asp Leu Arg Gln Gly Glu Ala Arg Arg Leu Arg Cys Met Glu 
305                 310                 315                 320 


Glu Lys Glu Met Phe Glu Leu Gln Cys Leu Ala Leu Arg Lys Asp Ser 
                325                 330                 335     


Lys Met Tyr Lys Asp Arg Ile Glu Ala Ile Leu Leu Gln Met Glu Glu 
            340                 345                 350         


Val Ala Ile Glu Arg Asp Gln Ala Ile Ala Thr Arg Glu Glu Leu His 
        355                 360                 365             


Ala Gln His Ala Arg Gly Leu Gln Glu Lys Asp Ala Leu Arg Lys Gln 
    370                 375                 380                 


Val Arg Glu Leu Gly Glu Lys Ala Asp Glu Leu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Gln Cys Glu Ala Gln Leu Leu Ala Val Glu Gly Arg Leu Arg Arg Gln 
                405                 410                 415     


Gln Leu Glu Thr Leu Val Leu Ser Ser Asp Leu Glu Asp Gly Ser Pro 
            420                 425                 430         


Arg Arg Ser Gln Glu Leu Ser Leu Pro Gln Asp Leu Glu Asp Thr Gln 
        435                 440                 445             


Leu Ser Asp Lys Gly Cys Leu Ala Gly Gly Gly Ser Pro Lys Gln Pro 
    450                 455                 460                 


Phe Ala Ala Leu His Gln Glu Gln Val Leu Arg Asn Pro His Asp Ala 
465                 470                 475                 480 


Gly Leu Ser Ser Gly Glu Pro Pro Glu Lys Glu Arg Arg Arg Leu Lys 
                485                 490                 495     


Glu Ser Phe Glu Asn Tyr Arg Arg Lys Arg Ala Leu Arg Lys Met Gln 
            500                 505                 510         


Lys Gly Trp Arg Gln Gly Glu Glu Asp Arg Glu Asn Thr Thr Gly Ser 
        515                 520                 525             


Asp Asn Thr Asp Thr Glu Gly Ser 
    530                 535     


<210>  1593
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARF__Homo_sapiens__NP_001098056

<400>  1593

Met Glu Gln Ser Asn Asp Ser Leu Arg Val Asn His Asn Asp Gly Glu 
1               5                   10                  15      


Glu Ser Lys Thr Ser Ala Gln Val Phe Glu His Leu Ile Cys Met Asp 
            20                  25                  30          


Ser Arg Asp Ser Ser Phe Gly Gln Asn Asp Ser Pro Thr Val Leu Pro 
        35                  40                  45              


Ile Thr Thr Arg Glu Ala Asn Asn Ser Leu Ile Ser Gln Asn Ile Pro 
    50                  55                  60                  


Gly Pro Leu Thr Gln Thr Gln Thr Leu Ser Ala Glu Gln Phe His Leu 
65                  70                  75                  80  


Val Asp Gln Asn Gly Gln Ala Ile Gln Tyr Glu Leu Gln Ser Leu Gly 
                85                  90                  95      


Glu Ser Asn Ala Gln Met Met Ile Val Ala Ser Pro Thr Glu Asn Gly 
            100                 105                 110         


Gln Val Leu Arg Val Ile Pro Pro Thr Gln Thr Gly Met Ala Gln Val 
        115                 120                 125             


Ile Ile Pro Gln Gly Gln Leu Val Asp Val Asn Ser Pro Arg Asp Val 
    130                 135                 140                 


Pro Glu Glu Lys Pro Ser Asn Arg Asn Leu Pro Thr Val Arg Val Asp 
145                 150                 155                 160 


Thr Leu Ala Asp Asn Thr Ser Asn Tyr Ile Leu His Pro Gln Thr Ser 
                165                 170                 175     


Phe Pro Leu Pro Lys Lys Ser Val Thr Gly Met Leu Glu Glu Pro Leu 
            180                 185                 190         


Leu Gly Pro Leu Gln Pro Leu Ser Ser Asn Thr Pro Ile Trp Ala Cys 
        195                 200                 205             


Arg Leu Arg Ser Cys Glu Lys Ile Gly Asp Ser Tyr Arg Gly Tyr Cys 
    210                 215                 220                 


Val Ser Glu Thr Glu Leu Glu Ser Val Leu Thr Phe His Lys Gln Gln 
225                 230                 235                 240 


Thr Gln Ser Val Trp Gly Thr Arg Gln Ser Pro Ser Pro Ala Lys Pro 
                245                 250                 255     


Ala Thr Arg Leu Met Trp Lys Ser Gln Tyr Val Pro Tyr Asp Gly Ile 
            260                 265                 270         


Pro Phe Val Asn Ala Gly Ser Arg Ala Val Val Met Glu Cys Gln Tyr 
        275                 280                 285             


Gly Pro Arg Arg Lys Gly Phe Gln Leu Lys Lys Val Ser Glu Gln Glu 
    290                 295                 300                 


Ser Arg Ser Cys Gln Leu Tyr Lys Ala Thr Cys Pro Ala Arg Ile Tyr 
305                 310                 315                 320 


Ile Lys Lys Val Gln Lys Phe Pro Glu Tyr Arg Val Pro Thr Asp Pro 
                325                 330                 335     


Lys Ile Asp Lys Lys Ile Ile Arg Met Glu Gln Glu Lys Ala Phe Asn 
            340                 345                 350         


Met Leu Lys Lys Asn Leu Val Asp Ala Gly Gly Val Leu Arg Trp Tyr 
        355                 360                 365             


Val Gln Leu Pro Thr Gln Gln Ala His Gln Tyr His Glu Leu Glu Thr 
    370                 375                 380                 


Pro Cys Leu Thr Leu Ser Pro Ser Pro Phe Pro Val Ser Ser Leu Glu 
385                 390                 395                 400 


Glu Glu Glu Thr Ala Val Arg Asp Glu Asn Cys Ala Leu Pro Ser Arg 
                405                 410                 415     


Leu His Pro Gln Val Ala His Lys Ile Gln Glu Leu Val Ser Gln Gly 
            420                 425                 430         


Ile Glu Gln Val Tyr Ala Val Arg Lys Gln Leu Arg Lys Phe Val Glu 
        435                 440                 445             


Arg Glu Leu Phe Lys Pro Asp Glu Val Pro Glu Arg His Asn Leu Ser 
    450                 455                 460                 


Phe Phe Pro Thr Val Asn Asp Ile Lys Asn His Ile His Glu Val Gln 
465                 470                 475                 480 


Lys Ser Leu Arg Asn Gly Asp Thr Val Tyr Asn Ser Glu Ile Ile Pro 
                485                 490                 495     


Ala Thr Leu Gln Trp Thr Thr Asp Ser Gly Asn Ile Leu Lys Glu Thr 
            500                 505                 510         


Met Thr Val Thr Phe Ala Glu Gly Asn Ser Pro Gly Glu Ser Ile Thr 
        515                 520                 525             


Thr Lys Val Glu Thr Asn Gln Thr Arg Gly Ser Leu Ser Pro Glu Pro 
    530                 535                 540                 


Thr His Leu Leu Ser Ser Leu Ser Ser Phe Gln Pro Lys Ile Phe Thr 
545                 550                 555                 560 


Gln Leu Gln Gly Leu Gln Leu Gln Pro Arg Tyr Thr Ser Pro Asp Glu 
                565                 570                 575     


Ser Pro Ala Val Val Ser Val Asn Asn Gln Pro Ser Ser Ser Pro Ser 
            580                 585                 590         


Gly Leu Leu Asp Thr Ile Gly Ser Ala Val Met Asn Asn Asn Ser Leu 
        595                 600                 605             


Leu Leu Gly Gln Ser His Ser Leu Gln Arg Asp Thr Cys Leu Thr Gln 
    610                 615                 620                 


Asn Asn Ser Thr Ala Ser Thr Met Gly Asn Leu Pro Glu Pro Asp Gln 
625                 630                 635                 640 


Asn Leu Val Ala Met Asp Glu Leu Val Glu Val Gly Asp Val Glu Asp 
                645                 650                 655     


Thr Gly Asn Leu Glu Gly Thr Val His Arg Ile Leu Leu Gly Asp Val 
            660                 665                 670         


Gln Thr Ile Pro Ile Gln Ile Ile Asp Asn His Ser Ala Leu Ile Glu 
        675                 680                 685             


Glu Asn Pro Glu Ser Thr Ile Ser Val Ser Gln Val Lys Gln Glu Pro 
    690                 695                 700                 


Lys Glu Pro Ala Leu Ser Met Glu Ala Lys Lys Thr Val Asp Tyr Lys 
705                 710                 715                 720 


Lys Leu Ser Ala Thr 
                725 


<210>  1594
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARKD__Homo_sapiens__NP_001229810

<400>  1594

Met Val Thr Arg Ala Gly Ala Gly Thr Ala Val Ala Gly Ala Val Val 
1               5                   10                  15      


Val Ala Leu Leu Ser Ala Ala Leu Ala Leu Tyr Gly Pro Pro Leu Asp 
            20                  25                  30          


Ala Val Leu Glu Arg Ala Phe Ser Leu Arg Lys Ala His Ser Ile Lys 
        35                  40                  45              


Asp Met Glu Asn Thr Leu Gln Leu Val Arg Asn Ile Ile Pro Pro Leu 
    50                  55                  60                  


Ser Ser Thr Lys His Lys Gly Gln Asp Gly Arg Ile Gly Val Val Gly 
65                  70                  75                  80  


Gly Cys Gln Glu Tyr Thr Gly Ala Pro Tyr Phe Ala Ala Ile Ser Ala 
                85                  90                  95      


Leu Lys Val Gly Ala Asp Leu Ser His Val Phe Cys Ala Ser Ala Ala 
            100                 105                 110         


Ala Pro Val Ile Lys Ala Tyr Ser Pro Glu Leu Ile Val His Pro Val 
        115                 120                 125             


Leu Asp Ser Pro Asn Ala Val His Glu Val Glu Lys Trp Leu Pro Arg 
    130                 135                 140                 


Leu His Ala Leu Val Val Gly Pro Gly Leu Gly Arg Asp Asp Ala Leu 
145                 150                 155                 160 


Leu Arg Asn Val Gln Gly Ile Leu Glu Val Ser Lys Ala Arg Asp Ile 
                165                 170                 175     


Pro Val Val Ile Asp Ala Asp Gly Leu Trp Leu Val Ala Gln Gln Pro 
            180                 185                 190         


Ala Leu Ile His Gly Tyr Arg Lys Ala Val Leu Thr Pro Asn His Val 
        195                 200                 205             


Glu Phe Ser Arg Leu Tyr Asp Ala Val Leu Arg Gly Pro Met Asp Ser 
    210                 215                 220                 


Asp Asp Ser His Gly Ser Val Leu Arg Leu Ser Gln Ala Leu Gly Asn 
225                 230                 235                 240 


Val Thr Val Val Gln Lys Gly Glu Arg Asp Ile Leu Ser Asn Gly Gln 
                245                 250                 255     


Gln Val Leu Val Cys Ser Gln Glu Gly Ser Ser Arg Arg Cys Gly Gly 
            260                 265                 270         


Gln Gly Asp Leu Leu Ser Gly Ser Leu Gly Val Leu Val His Trp Ala 
        275                 280                 285             


Leu Leu Ala Gly Pro Gln Lys Thr Asn Gly Ser Ser Pro Leu Leu Val 
    290                 295                 300                 


Ala Ala Phe Gly Ala Cys Ser Leu Thr Arg Gln Cys Asn His Gln Ala 
305                 310                 315                 320 


Phe Gln Lys His Gly Arg Ser Thr Thr Thr Ser Asp Met Ile Ala Glu 
                325                 330                 335     


Val Gly Ala Ala Phe Ser Lys Leu Phe Glu Thr 
            340                 345         


<210>  1595
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARM1__Homo_sapiens__NP_954592

<400>  1595

Met Ala Ala Ala Ala Ala Ala Val Gly Pro Gly Ala Gly Gly Ala Gly 
1               5                   10                  15      


Ser Ala Val Pro Gly Gly Ala Gly Pro Cys Ala Thr Val Ser Val Phe 
            20                  25                  30          


Pro Gly Ala Arg Leu Leu Thr Ile Gly Asp Ala Asn Gly Glu Ile Gln 
        35                  40                  45              


Arg His Ala Glu Gln Gln Ala Leu Arg Leu Glu Val Arg Ala Gly Pro 
    50                  55                  60                  


Asp Ser Ala Gly Ile Ala Leu Tyr Ser His Glu Asp Val Cys Val Phe 
65                  70                  75                  80  


Lys Cys Ser Val Ser Arg Glu Thr Glu Cys Ser Arg Val Gly Lys Gln 
                85                  90                  95      


Ser Phe Ile Ile Thr Leu Gly Cys Asn Ser Val Leu Ile Gln Phe Ala 
            100                 105                 110         


Thr Pro Asn Asp Phe Cys Ser Phe Tyr Asn Ile Leu Lys Thr Cys Arg 
        115                 120                 125             


Gly His Thr Leu Glu Arg Ser Val Phe Ser Glu Arg Thr Glu Glu Ser 
    130                 135                 140                 


Ser Ala Val Gln Tyr Phe Gln Phe Tyr Gly Tyr Leu Ser Gln Gln Gln 
145                 150                 155                 160 


Asn Met Met Gln Asp Tyr Val Arg Thr Gly Thr Tyr Gln Arg Ala Ile 
                165                 170                 175     


Leu Gln Asn His Thr Asp Phe Lys Asp Lys Ile Val Leu Asp Val Gly 
            180                 185                 190         


Cys Gly Ser Gly Ile Leu Ser Phe Phe Ala Ala Gln Ala Gly Ala Arg 
        195                 200                 205             


Lys Ile Tyr Ala Val Glu Ala Ser Thr Met Ala Gln His Ala Glu Val 
    210                 215                 220                 


Leu Val Lys Ser Asn Asn Leu Thr Asp Arg Ile Val Val Ile Pro Gly 
225                 230                 235                 240 


Lys Val Glu Glu Val Ser Leu Pro Glu Gln Val Asp Ile Ile Ile Ser 
                245                 250                 255     


Glu Pro Met Gly Tyr Met Leu Phe Asn Glu Arg Met Leu Glu Ser Tyr 
            260                 265                 270         


Leu His Ala Lys Lys Tyr Leu Lys Pro Ser Gly Asn Met Phe Pro Thr 
        275                 280                 285             


Ile Gly Asp Val His Leu Ala Pro Phe Thr Asp Glu Gln Leu Tyr Met 
    290                 295                 300                 


Glu Gln Phe Thr Lys Ala Asn Phe Trp Tyr Gln Pro Ser Phe His Gly 
305                 310                 315                 320 


Val Asp Leu Ser Ala Leu Arg Gly Ala Ala Val Asp Glu Tyr Phe Arg 
                325                 330                 335     


Gln Pro Val Val Asp Thr Phe Asp Ile Arg Ile Leu Met Ala Lys Ser 
            340                 345                 350         


Val Lys Tyr Thr Val Asn Phe Leu Glu Ala Lys Glu Gly Asp Leu His 
        355                 360                 365             


Arg Ile Glu Ile Pro Phe Lys Phe His Met Leu His Ser Gly Leu Val 
    370                 375                 380                 


His Gly Leu Ala Phe Trp Phe Asp Val Ala Phe Ile Gly Ser Ile Met 
385                 390                 395                 400 


Thr Val Trp Leu Ser Thr Ala Pro Thr Glu Pro Leu Thr His Trp Tyr 
                405                 410                 415     


Gln Val Arg Cys Leu Phe Gln Ser Pro Leu Phe Ala Lys Ala Gly Asp 
            420                 425                 430         


Thr Leu Ser Gly Thr Cys Leu Leu Ile Ala Asn Lys Arg Gln Ser Tyr 
        435                 440                 445             


Asp Ile Ser Ile Val Ala Gln Val Asp Gln Thr Gly Ser Lys Ser Ser 
    450                 455                 460                 


Asn Leu Leu Asp Leu Lys Asn Pro Phe Phe Arg Tyr Thr Gly Thr Thr 
465                 470                 475                 480 


Pro Ser Pro Pro Pro Gly Ser His Tyr Thr Ser Pro Ser Glu Asn Met 
                485                 490                 495     


Trp Asn Thr Gly Ser Thr Tyr Asn Leu Ser Ser Gly Met Ala Val Ala 
            500                 505                 510         


Gly Met Pro Thr Ala Tyr Asp Leu Ser Ser Val Ile Ala Ser Gly Ser 
        515                 520                 525             


Ser Val Gly His Asn Asn Leu Ile Pro Leu Ala Asn Thr Gly Ile Val 
    530                 535                 540                 


Asn His Thr His Ser Arg Met Gly Ser Ile Met Ser Thr Gly Ile Val 
545                 550                 555                 560 


Gln Gly Ser Ser Gly Ala Gln Gly Ser Gly Gly Gly Ser Thr Ser Ala 
                565                 570                 575     


His Tyr Ala Val Asn Ser Gln Phe Thr Met Gly Gly Pro Ala Ile Ser 
            580                 585                 590         


Met Ala Ser Pro Met Ser Ile Pro Thr Asn Thr Met His Tyr Gly Ser 
        595                 600                 605             


<210>  1596
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARS__Homo_sapiens__NP_001014437

<400>  1596

Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu 
1               5                   10                  15      


Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu 
            20                  25                  30          


Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val 
        35                  40                  45              


Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe 
    50                  55                  60                  


His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro 
65                  70                  75                  80  


Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg 
                85                  90                  95      


Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu 
            100                 105                 110         


His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln 
        115                 120                 125             


Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp 
    130                 135                 140                 


Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu 
145                 150                 155                 160 


Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met 
                165                 170                 175     


Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn 
            180                 185                 190         


His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu 
        195                 200                 205             


Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn 
    210                 215                 220                 


Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His 
225                 230                 235                 240 


Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg 
                245                 250                 255     


Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu 
            260                 265                 270         


Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp 
        275                 280                 285             


Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly 
    290                 295                 300                 


Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val 
305                 310                 315                 320 


Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln 
                325                 330                 335     


Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr 
            340                 345                 350         


Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys 
        355                 360                 365             


Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu 
    370                 375                 380                 


Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro 
385                 390                 395                 400 


Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp 
                405                 410                 415     


Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser 
            420                 425                 430         


Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly 
        435                 440                 445             


Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser 
    450                 455                 460                 


Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr 
465                 470                 475                 480 


Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn 
                485                 490                 495     


Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu 
            500                 505                 510         


Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser 
        515                 520                 525             


Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu 
    530                 535                 540                 


Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr 
545                 550                 555                 560 


Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn 
                565                 570                 575     


Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val 
            580                 585                 590         


Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys 
        595                 600                 605             


Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln 
    610                 615                 620                 


Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile 
625                 630                 635                 640 


Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly 
                645                 650                 655     


Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln 
            660                 665                 670         


Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln 
        675                 680                 685             


Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile 
    690                 695                 700                 


Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr 
705                 710                 715                 720 


Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu 
                725                 730                 735     


Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala 
            740                 745                 750         


Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile 
        755                 760                 765             


Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe 
    770                 775                 780                 


Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser 
785                 790                 795                 800 


Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys 
                805                 810                 815     


Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln 
            820                 825                 830     


<210>  1597
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CARTPT__Homo_sapiens__NP_004282

<400>  1597

Met Glu Ser Ser Arg Val Arg Leu Leu Pro Leu Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Met Leu Pro Leu Leu Gly Thr Arg Ala Gln Glu Asp Ala Glu 
            20                  25                  30          


Leu Gln Pro Arg Ala Leu Asp Ile Tyr Ser Ala Val Asp Asp Ala Ser 
        35                  40                  45              


His Glu Lys Glu Leu Ile Glu Ala Leu Gln Glu Val Leu Lys Lys Leu 
    50                  55                  60                  


Lys Ser Lys Arg Val Pro Ile Tyr Glu Lys Lys Tyr Gly Gln Val Pro 
65                  70                  75                  80  


Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg Lys Gly Ala Arg Ile 
                85                  90                  95      


Gly Lys Leu Cys Asp Cys Pro Arg Gly Thr Ser Cys Asn Ser Phe Leu 
            100                 105                 110         


Leu Lys Cys Leu 
        115     


<210>  1598
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASC1__Homo_sapiens__NP_001076441

<400>  1598

Met Arg Gln Thr Gly Gly Gly Ala Thr Thr Asp Ser Ala Ser Pro Val 
1               5                   10                  15      


Leu Asn Asn Val Ile Lys Ser Gln Ser Tyr Phe Thr Ala Lys Arg Val 
            20                  25                  30          


Gly Leu Gly Asn Asn Ser Tyr Leu Gly Val Gly Arg Pro Ser Ser Gln 
        35                  40                  45              


Gln Trp Leu Ser Leu Pro Gly Pro Gly Gly Gln Gly Pro Lys Ala Lys 
    50                  55                  60                  


Lys Ser Gly Ser Lys Lys Lys Lys Val Thr Lys Ala Glu Arg Leu Lys 
65                  70                  75                  80  


Leu Leu Gln Glu Glu Glu Glu Arg Arg Leu Lys Glu Glu Glu Glu Ala 
                85                  90                  95      


Arg Leu Lys Tyr Glu Lys Glu Glu Met Glu Arg Leu Glu Ile Gln Arg 
            100                 105                 110         


Ile Glu Lys Glu Lys Trp His Arg Leu Glu Ala Lys Asp Leu Glu Arg 
        115                 120                 125             


Arg Asn Glu Glu Leu Glu Glu Leu Tyr Leu Leu Glu Arg Cys Phe Pro 
    130                 135                 140                 


Glu Ala Glu Lys Leu Lys Gln Glu Thr Lys Leu Leu Ser Gln Trp Lys 
145                 150                 155                 160 


His Tyr Ile Gln Cys Asp Gly Ser Pro Asp Pro Ser Val Ala Gln Glu 
                165                 170                 175     


Met Asn Thr Phe Ile Ser Leu Trp Lys Glu Lys Thr Asn Glu Thr Phe 
            180                 185                 190         


Glu Glu Val Ile Glu Lys Ser Lys Val Val Leu Asn Leu Ile Glu Lys 
        195                 200                 205             


Leu Lys Phe Ile Leu Leu Glu Thr Pro Pro Cys Asp Leu Gln Asp Lys 
    210                 215                 220                 


Asn Ile Ile Gln Tyr Gln Glu Ser Ile Leu Gln Leu Gln Glu Leu Leu 
225                 230                 235                 240 


His Leu Lys Phe Gly Val Ala Thr Glu Ile Leu Leu Lys Gln Ala Ser 
                245                 250                 255     


Thr Leu Ala Asp Leu Asp Ser Gly Asn Met Glu Lys Val Ile Lys Asp 
            260                 265                 270         


Glu Asn Val Thr Leu Tyr Val Trp Ala Asn Leu Lys Lys Asn Pro Arg 
        275                 280                 285             


His Arg Ser Val Arg Phe Ser Glu Thr Gln Ile Gly Phe Glu Ile Pro 
    290                 295                 300                 


Arg Ile Leu Ala Thr Ser Asp Ile Ala Val Arg Leu Leu His Thr His 
305                 310                 315                 320 


Tyr Asp His Val Ser Ala Leu His Pro Val Ser Thr Pro Ser Lys Glu 
                325                 330                 335     


Tyr Thr Ser Ala Val Thr Glu Leu Val Lys Asp Asp Val Lys Asn Val 
            340                 345                 350         


Glu Lys Ala Ile Ser Lys Glu Val Glu Glu Glu Ser Lys Gln Gln Glu 
        355                 360                 365             


Arg Gly Ser His Leu Ile Gln Glu Glu Glu Ile Lys Val Glu Glu Glu 
    370                 375                 380                 


Gln Gly Asp Ile Glu Val Lys Met Ser Ser Ala Glu Glu Glu Ser Glu 
385                 390                 395                 400 


Ala Ile Lys Cys Glu Arg Glu Met Lys Val Leu Ser Glu Thr Val Ser 
                405                 410                 415     


Ala Ala Gln Leu Leu Leu Val Glu Asn Ser Ser Glu Lys Pro Asp Phe 
            420                 425                 430         


Phe Glu Asp Asn Val Val Asp Leu Cys Gln Phe Thr Thr Leu Gly Gly 
        435                 440                 445             


Val Tyr His Leu Asp Ile Leu Glu Leu Pro Pro Gln Cys Lys Pro Val 
    450                 455                 460                 


Lys Gly Trp Met Ile Val Glu Ile Leu Lys Glu Gly Leu Gln Lys Tyr 
465                 470                 475                 480 


Thr Tyr Pro Pro Glu Thr Thr Glu Glu Phe Glu Thr Glu Asn Ala Phe 
                485                 490                 495     


Pro Pro Ile Glu Val Thr Leu Glu Val His Glu Asn Val Ile Phe Phe 
            500                 505                 510         


Glu Asp Pro Val Val Val Arg Trp Asp Ala Glu Gly Lys His Trp Arg 
        515                 520                 525             


Thr Asp Gly Ile Ser Asn Val Ser Tyr Lys Pro Lys Glu Arg Leu Val 
    530                 535                 540                 


Thr Phe Ser Leu Asp Thr Phe Gly Pro Val Thr Leu Ile Gln Asp Ala 
545                 550                 555                 560 


His Ile Asn Met Pro Tyr Gln Ser Trp Glu Leu Arg Pro Leu Asp Val 
                565                 570                 575     


Asn Lys Val Leu Leu Thr Val Thr Thr Val Phe Thr Glu Ile Gln Ile 
            580                 585                 590         


Gln Ile Lys Glu Asn Leu Cys Met Leu Ser Ser Ile Lys Leu Lys Asp 
        595                 600                 605             


Lys Lys His Ile Ser Ile Leu Glu Gly Thr Trp Met Thr Pro Ile Pro 
    610                 615                 620                 


Phe Ile Ile Ala Leu Lys Glu Ala Gly Leu Asn Ile Phe Pro Thr Arg 
625                 630                 635                 640 


His Ser His Phe Tyr Val Ile Ile Asn Asn Lys Val Pro Leu Val Glu 
                645                 650                 655     


Val Lys Ala Tyr Arg Gln Met Ala Leu Leu Ser Ser Ala Phe Ala Phe 
            660                 665                 670         


Gly Trp Ser Lys Trp Asn Leu Leu Cys Asn Ser Thr Lys Val Val Phe 
        675                 680                 685             


Lys Trp 
    690 


<210>  1599
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASC3__Homo_sapiens__XP_005257220

<400>  1599

Met Ala Asp Arg Arg Arg Gln Arg Ala Ser Gln Asp Thr Glu Asp Glu 
1               5                   10                  15      


Glu Ser Gly Ala Ser Gly Ser Asp Ser Gly Gly Ser Pro Leu Arg Gly 
            20                  25                  30          


Gly Gly Ser Cys Ser Gly Ser Ala Gly Gly Gly Gly Ser Gly Ser Leu 
        35                  40                  45              


Pro Ser Gln Arg Gly Gly Arg Thr Gly Ala Leu His Leu Arg Arg Val 
    50                  55                  60                  


Glu Ser Gly Gly Ala Lys Ser Ala Glu Glu Ser Glu Cys Glu Ser Glu 
65                  70                  75                  80  


Asp Gly Ile Glu Gly Asp Ala Val Leu Ser Asp Tyr Glu Ser Ala Glu 
                85                  90                  95      


Asp Ser Glu Gly Glu Glu Gly Glu Tyr Ser Glu Glu Glu Asn Ser Lys 
            100                 105                 110         


Val Glu Leu Lys Ser Glu Ala Asn Asp Ala Val Asn Ser Ser Thr Lys 
        115                 120                 125             


Glu Glu Lys Gly Glu Glu Lys Pro Asp Thr Lys Ser Thr Val Thr Gly 
    130                 135                 140                 


Glu Arg Gln Ser Gly Asp Gly Gln Glu Ser Thr Glu Pro Val Glu Asn 
145                 150                 155                 160 


Lys Val Gly Lys Lys Gly Pro Lys His Leu Asp Asp Asp Glu Asp Arg 
                165                 170                 175     


Lys Asn Pro Ala Tyr Ile Pro Arg Lys Gly Leu Phe Phe Glu His Asp 
            180                 185                 190         


Leu Arg Gly Gln Thr Gln Glu Glu Glu Val Arg Pro Lys Gly Arg Gln 
        195                 200                 205             


Arg Lys Leu Trp Lys Asp Glu Gly Arg Trp Glu His Asp Lys Phe Arg 
    210                 215                 220                 


Glu Asp Glu Gln Ala Pro Lys Ser Arg Gln Glu Leu Ile Ala Leu Tyr 
225                 230                 235                 240 


Gly Tyr Asp Ile Arg Ser Ala His Asn Pro Asp Asp Ile Lys Pro Arg 
                245                 250                 255     


Arg Ile Arg Lys Pro Arg Tyr Gly Ser Pro Pro Gln Arg Asp Pro Asn 
            260                 265                 270         


Trp Asn Gly Glu Arg Leu Asn Lys Ser His Arg His Gln Gly Leu Gly 
        275                 280                 285             


Gly Thr Leu Pro Pro Arg Thr Phe Ile Asn Arg Asn Ala Ala Gly Thr 
    290                 295                 300                 


Gly Arg Met Ser Ala Pro Arg Asn Tyr Ser Arg Ser Gly Gly Phe Lys 
305                 310                 315                 320 


Glu Gly Arg Ala Gly Phe Arg Pro Val Glu Ala Gly Gly Gln His Gly 
                325                 330                 335     


Gly Arg Ser Gly Glu Thr Val Lys His Glu Ile Ser Tyr Arg Ser Arg 
            340                 345                 350         


Arg Leu Glu Gln Thr Ser Val Arg Asp Pro Ser Pro Glu Ala Asp Ala 
        355                 360                 365             


Pro Val Leu Gly Ser Pro Glu Lys Glu Glu Ala Ala Ser Glu Pro Pro 
    370                 375                 380                 


Ala Ala Ala Pro Asp Ala Ala Pro Pro Pro Pro Asp Arg Pro Ile Glu 
385                 390                 395                 400 


Lys Lys Ser Tyr Ser Arg Ala Arg Arg Thr Arg Thr Lys Val Gly Asp 
                405                 410                 415     


Ala Val Lys Leu Ala Glu Glu Val Pro Pro Pro Pro Glu Gly Leu Ile 
            420                 425                 430         


Pro Ala Pro Pro Val Pro Glu Thr Thr Pro Thr Pro Pro Thr Lys Thr 
        435                 440                 445             


Gly Thr Trp Glu Ala Pro Val Asp Ser Ser Thr Ser Gly Leu Glu Gln 
    450                 455                 460                 


Asp Val Ala Gln Leu Asn Ile Ala Glu Gln Asn Trp Ser Pro Gly Gln 
465                 470                 475                 480 


Pro Ser Phe Leu Gln Pro Arg Glu Leu Arg Gly Met Pro Asn His Ile 
                485                 490                 495     


His Met Gly Ala Gly Pro Pro Pro Gln Phe Asn Arg Met Glu Glu Met 
            500                 505                 510         


Gly Val Gln Gly Gly Arg Ala Lys Arg Tyr Ser Ser Gln Arg Gln Arg 
        515                 520                 525             


Pro Val Pro Glu Pro Pro Ala Pro Pro Val His Ile Ser Ile Met Glu 
    530                 535                 540                 


Gly His Tyr Tyr Asp Pro Leu Gln Phe Gln Gly Pro Ile Tyr Thr His 
545                 550                 555                 560 


Gly Asp Ser Pro Ala Pro Leu Pro Pro Gln Gly Met Leu Val Gln Pro 
                565                 570                 575     


Gly Met Asn Leu Pro His Pro Gly Leu His Pro His Gln Thr Pro Ala 
            580                 585                 590         


Pro Leu Pro Asn Pro Gly Leu Tyr Pro Pro Pro Val Ser Met Ser Pro 
        595                 600                 605             


Gly Gln Pro Pro Pro Gln Gln Leu Leu Ala Pro Thr Tyr Phe Ser Ala 
    610                 615                 620                 


Pro Gly Val Met Asn Phe Gly Asn Pro Ser Tyr Pro Tyr Ala Pro Gly 
625                 630                 635                 640 


Ala Leu Pro Pro Pro Pro Pro Pro His Leu Tyr Pro Asn Thr Gln Ala 
                645                 650                 655     


Pro Ser Gln Val Tyr Gly Gly Val Thr Tyr Tyr Asn Pro Ala Gln Gln 
            660                 665                 670         


Gln Val Gln Pro Lys Pro Ser Pro Pro Arg Arg Thr Pro Gln Pro Val 
        675                 680                 685             


Thr Ile Lys Pro Pro Pro Pro Glu Val Val Ser Arg Gly Ser Ser 
    690                 695                 700             


<210>  1600
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASC4__Homo_sapiens__NP_612432

<400>  1600

Met Val Gly Phe Gly Ala Asn Arg Arg Ala Gly Arg Leu Pro Ser Leu 
1               5                   10                  15      


Val Leu Val Val Leu Leu Val Val Ile Val Val Leu Ala Phe Asn Tyr 
            20                  25                  30          


Trp Ser Ile Ser Ser Arg His Val Leu Leu Gln Glu Glu Val Ala Glu 
        35                  40                  45              


Leu Gln Gly Gln Val Gln Arg Thr Glu Val Ala Arg Gly Arg Leu Glu 
    50                  55                  60                  


Lys Arg Asn Ser Asp Leu Leu Leu Leu Val Asp Thr His Lys Lys Gln 
65                  70                  75                  80  


Ile Asp Gln Lys Glu Ala Asp Tyr Gly Arg Leu Ser Ser Arg Leu Gln 
                85                  90                  95      


Ala Arg Glu Gly Leu Gly Lys Arg Cys Glu Asp Asp Lys Val Lys Leu 
            100                 105                 110         


Gln Asn Asn Ile Ser Tyr Gln Met Ala Asp Ile His His Leu Lys Glu 
        115                 120                 125             


Gln Leu Ala Glu Leu Arg Gln Glu Phe Leu Arg Gln Glu Asp Gln Leu 
    130                 135                 140                 


Gln Asp Tyr Arg Lys Asn Asn Thr Tyr Leu Val Lys Arg Leu Glu Tyr 
145                 150                 155                 160 


Glu Ser Phe Gln Cys Gly Gln Gln Met Lys Glu Leu Arg Ala Gln His 
                165                 170                 175     


Glu Glu Asn Ile Lys Lys Leu Ala Asp Gln Phe Leu Glu Glu Gln Lys 
            180                 185                 190         


Gln Glu Thr Gln Lys Ile Gln Ser Asn Asp Gly Lys Glu Leu Asp Ile 
        195                 200                 205             


Asn Asn Gln Val Val Pro Lys Asn Ile Pro Lys Val Ala Glu Asn Val 
    210                 215                 220                 


Ala Asp Lys Asn Glu Glu Pro Ser Ser Asn His Ile Pro His Gly Lys 
225                 230                 235                 240 


Glu Gln Ile Lys Arg Gly Gly Asp Ala Gly Met Pro Gly Ile Glu Glu 
                245                 250                 255     


Asn Asp Leu Ala Lys Val Asp Asp Leu Pro Pro Ala Leu Arg Lys Pro 
            260                 265                 270         


Pro Ile Ser Val Ser Gln His Glu Ser His Gln Ala Ile Ser His Leu 
        275                 280                 285             


Pro Thr Gly Gln Pro Leu Ser Pro Asn Met Pro Pro Asp Ser His Ile 
    290                 295                 300                 


Asn His Asn Gly Asn Pro Gly Thr Ser Lys Gln Asn Pro Ser Ser Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Ile Pro Gly Ser Asn Leu Asp Ser Glu Pro Arg Ile 
                325                 330                 335     


Gln Thr Asp Ile Leu Lys Gln Ala Thr Lys Asp Arg Val Ser Asp Phe 
            340                 345                 350         


His Lys Leu Lys Gln Ser Arg Phe Phe Asp Glu Asn Glu Ser Pro Val 
        355                 360                 365             


Asp Pro Gln His Gly Ser Lys Leu Ala Asp Tyr Asn Gly Asp Asp Gly 
    370                 375                 380                 


Asn Val Gly Glu Tyr Glu Ala Asp Lys Gln Ala Glu Leu Ala Tyr Asn 
385                 390                 395                 400 


Glu Glu Glu Asp Gly Asp Gly Gly Glu Glu Asp Val Gln Asp Asp Glu 
                405                 410                 415     


Glu Arg Glu Leu Gln Met Asp Pro Ala Asp Tyr Gly Lys Gln His Phe 
            420                 425                 430         


Asn Asp Val Leu 
        435     


<210>  1601
<211>  2316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASC5__Homo_sapiens__NP_653091

<400>  1601

Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu 
1               5                   10                  15      


Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser 
            20                  25                  30          


Pro Leu Gln Asp Leu Arg Gly Gly Asn Glu Arg Val Gln Glu Ser Asn 
        35                  40                  45              


Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr 
    50                  55                  60                  


Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser 
65                  70                  75                  80  


Glu Met Glu Glu Thr Glu Thr Gly Glu Asn Leu Leu Leu Ile Gln Asn 
                85                  90                  95      


Lys Lys Leu Glu Asp Asn Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu 
            100                 105                 110         


Leu Ser Ala Pro Ile His Thr Gln Met Gln Gln Lys Glu Phe Ser Ile 
        115                 120                 125             


Ile Glu His Thr Arg Glu Arg Lys His Ala Asn Asp Gln Thr Val Ile 
    130                 135                 140                 


Phe Ser Asp Glu Asn Gln Met Asp Leu Thr Ser Ser His Thr Val Met 
145                 150                 155                 160 


Ile Thr Lys Gly Leu Leu Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys 
                165                 170                 175     


Ile Asp Thr Thr Ser Phe Leu Ala Asn Leu Lys Leu His Thr Glu Asp 
            180                 185                 190         


Ser Arg Met Lys Lys Glu Val Asn Phe Ser Val Asp Gln Asn Thr Ser 
        195                 200                 205             


Ser Glu Asn Lys Ile Asp Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr 
    210                 215                 220                 


Gly Lys Cys Ser Ala Phe Pro Asp Val Pro Asp Lys Glu Asn Phe Glu 
225                 230                 235                 240 


Ile Pro Ile Tyr Ser Lys Glu Pro Asn Ser Ala Ser Ser Thr His Gln 
                245                 250                 255     


Met His Val Ser Leu Lys Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg 
            260                 265                 270         


Leu Phe Arg Glu Lys Asp Asp Gly Met Asn Phe Thr Gln Cys His Thr 
        275                 280                 285             


Ala Asn Ile Gln Thr Leu Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg 
    290                 295                 300                 


Glu Ser Lys Gly Asn Asp Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp 
305                 310                 315                 320 


Leu Thr Phe Asn His Thr Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe 
                325                 330                 335     


Ser Glu Ile Glu Asn Gln Thr Gln Asn Ala Met Asp Val Thr Thr Gly 
            340                 345                 350         


Tyr Gly Thr Lys Ala Ser Gly Asn Lys Thr Val Phe Lys Ser Lys Gln 
        355                 360                 365             


Asn Thr Ala Phe Gln Asp Leu Ser Ile Asn Ser Ala Asp Lys Ile His 
    370                 375                 380                 


Ile Thr Arg Ser His Ile Met Gly Ala Glu Thr His Ile Val Ser Gln 
385                 390                 395                 400 


Thr Cys Asn Gln Asp Ala Arg Ile Leu Ala Met Thr Pro Glu Ser Ile 
                405                 410                 415     


Tyr Ser Asn Pro Ser Ile Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser 
            420                 425                 430         


Cys Asn Asp Ala Met Glu Met Thr Lys Cys Leu Ser Asn Met Arg Glu 
        435                 440                 445             


Glu Lys Asn Leu Leu Lys His Asp Ser Asn Tyr Ala Lys Met Tyr Cys 
    450                 455                 460                 


Asn Pro Asp Ala Met Ser Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly 
465                 470                 475                 480 


Glu Glu Asn Met Asp Ile Thr Lys Ser His Thr Val Ala Ile Asp Asn 
                485                 490                 495     


Gln Ile Phe Lys Gln Asp Gln Ser Asn Val Gln Ile Ala Ala Ala Pro 
            500                 505                 510         


Thr Pro Glu Lys Glu Met Met Leu Gln Asn Leu Met Thr Thr Ser Glu 
        515                 520                 525             


Asp Gly Lys Met Asn Val Asn Cys Asn Ser Val Pro His Val Ser Lys 
    530                 535                 540                 


Glu Arg Ile Gln Gln Ser Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr 
545                 550                 555                 560 


Asp Arg Lys Thr Glu Leu Leu Ser Gly Glu Asn Met Asp Leu Thr Glu 
                565                 570                 575     


Ser His Thr Ser Asn Leu Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn 
            580                 585                 590         


Leu Ala Pro Glu Ser Thr Ser Glu Ser His Ser Gln Ser Lys Ser Ser 
        595                 600                 605             


Ser Asp Glu Cys Glu Glu Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln 
    610                 615                 620                 


Arg Ser Asp Ile Ile Ala Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys 
625                 630                 635                 640 


Asp Lys Asp Trp Val Leu Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser 
                645                 650                 655     


Pro Gln Ser Ala Asp Cys Asn Gln Glu Ile Ala Thr Ser His Asn Ile 
            660                 665                 670         


Val Tyr Cys Gly Gly Val Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr 
        675                 680                 685             


Val Ser Trp Glu Gln Ser Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser 
    690                 695                 700                 


Ser Gly Gln Phe Ser Met Lys Asn His Asp Thr Ala Ile Ser Ser His 
705                 710                 715                 720 


Thr Val Lys Ser Val Leu Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu 
                725                 730                 735     


Arg Lys Ser Leu Ser Asn Pro Thr Pro Asp Tyr Cys His Asp Lys Met 
            740                 745                 750         


Ile Ile Cys Ser Glu Glu Glu Gln Asn Met Asp Leu Thr Lys Ser His 
        755                 760                 765             


Thr Val Val Ile Gly Phe Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys 
    770                 775                 780                 


Thr Asn Leu Glu His Thr Thr Gly Gln Leu Thr Thr Met Asn Arg Gln 
785                 790                 795                 800 


Ile Ala Val Lys Val Glu Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser 
                805                 810                 815     


Gly Val Leu Lys Ser Asn Cys Ile Met Asp Val Leu Glu Asp Glu Ser 
            820                 825                 830         


Val Gln Lys Pro Lys Phe Pro Lys Glu Lys Gln Asn Val Lys Ile Trp 
        835                 840                 845             


Gly Arg Lys Ser Val Gly Gly Pro Lys Ile Asp Lys Thr Ile Val Phe 
    850                 855                 860                 


Ser Glu Asp Asp Lys Asn Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile 
865                 870                 875                 880 


Glu Ile Asn His Arg Pro Leu Leu Glu Lys Arg Asp Cys His Leu Val 
                885                 890                 895     


Pro Leu Ala Gly Thr Ser Glu Thr Ile Leu Tyr Thr Cys Arg Gln Asp 
            900                 905                 910         


Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu Glu Cys Lys Thr 
        915                 920                 925             


Val Ser Pro Asp Glu Ile Thr Thr Arg Pro Met Asp Lys Thr Val Val 
    930                 935                 940                 


Phe Val Asp Asn His Val Glu Leu Glu Met Thr Glu Ser His Thr Val 
945                 950                 955                 960 


Phe Ile Asp Tyr Gln Glu Lys Glu Arg Thr Asp Arg Pro Asn Phe Glu 
                965                 970                 975     


Leu Ser Gln Arg Lys Ser Leu Gly Thr Pro Thr Val Ile Cys Thr Pro 
            980                 985                 990         


Thr Glu Glu Ser Val Phe Phe Pro  Gly Asn Gly Glu Ser  Asp Arg Leu 
        995                 1000                 1005             


Val Ala  Asn Asp Ser Gln Leu  Thr Pro Leu Glu Glu  Trp Ser Asn 
    1010                 1015                 1020             


Asn Arg  Gly Pro Val Glu Val  Ala Asp Asn Met Glu  Leu Ser Lys 
    1025                 1030                 1035             


Ser Ala  Thr Cys Lys Asn Ile  Lys Asp Val Gln Ser  Pro Gly Phe 
    1040                 1045                 1050             


Leu Asn  Glu Pro Leu Ser Ser  Lys Ser Gln Arg Arg  Lys Ser Leu 
    1055                 1060                 1065             


Lys Leu  Lys Asn Asp Lys Thr  Ile Val Phe Ser Glu  Asn His Lys 
    1070                 1075                 1080             


Asn Asp  Met Asp Ile Thr Gln  Ser Cys Met Val Glu  Ile Asp Asn 
    1085                 1090                 1095             


Glu Ser  Ala Leu Glu Asp Lys  Glu Asp Phe His Leu  Ala Gly Ala 
    1100                 1105                 1110             


Ser Lys  Thr Ile Leu Tyr Ser  Cys Gly Gln Asp Asp  Met Glu Ile 
    1115                 1120                 1125             


Thr Arg  Ser His Thr Thr Ala  Leu Glu Cys Lys Thr  Leu Leu Pro 
    1130                 1135                 1140             


Asn Glu  Ile Ala Ile Arg Pro  Met Asp Lys Thr Val  Leu Phe Thr 
    1145                 1150                 1155             


Asp Asn  Tyr Ser Asp Leu Glu  Val Thr Asp Ser His  Thr Val Phe 
    1160                 1165                 1170             


Ile Asp  Cys Gln Ala Thr Glu  Lys Ile Leu Glu Glu  Asn Pro Lys 
    1175                 1180                 1185             


Phe Gly  Ile Gly Lys Gly Lys  Asn Leu Gly Val Ser  Phe Pro Lys 
    1190                 1195                 1200             


Asp Asn  Ser Cys Val Gln Glu  Ile Ala Glu Lys Gln  Ala Leu Ala 
    1205                 1210                 1215             


Val Gly  Asn Lys Ile Val Leu  His Thr Glu Gln Lys  Gln Gln Leu 
    1220                 1225                 1230             


Phe Ala  Ala Thr Asn Arg Thr  Thr Asn Glu Ile Ile  Lys Phe His 
    1235                 1240                 1245             


Ser Ala  Ala Met Asp Glu Lys  Val Ile Gly Lys Val  Val Asp Gln 
    1250                 1255                 1260             


Ala Cys  Thr Leu Glu Lys Ala  Gln Val Glu Ser Cys  Gln Leu Asn 
    1265                 1270                 1275             


Asn Arg  Asp Arg Arg Asn Val  Asp Phe Thr Ser Ser  His Ala Thr 
    1280                 1285                 1290             


Ala Val  Cys Gly Ser Ser Asp  Asn Tyr Ser Cys Leu  Pro Asn Val 
    1295                 1300                 1305             


Ile Ser  Cys Thr Asp Asn Leu  Glu Gly Ser Ala Met  Leu Leu Cys 
    1310                 1315                 1320             


Asp Lys  Asp Glu Glu Lys Ala  Asn Tyr Cys Pro Val  Gln Asn Asp 
    1325                 1330                 1335             


Leu Ala  Tyr Ala Asn Asp Phe  Ala Ser Glu Tyr Tyr  Leu Glu Ser 
    1340                 1345                 1350             


Glu Gly  Gln Pro Leu Ser Ala  Pro Cys Pro Leu Leu  Glu Lys Glu 
    1355                 1360                 1365             


Glu Val  Ile Gln Thr Ser Thr  Lys Gly Gln Leu Asp  Cys Val Ile 
    1370                 1375                 1380             


Thr Leu  His Lys Asp Gln Asp  Leu Ile Lys Asp Pro  Arg Asn Leu 
    1385                 1390                 1395             


Leu Ala  Asn Gln Thr Leu Val  Tyr Ser Gln Asp Leu  Gly Glu Met 
    1400                 1405                 1410             


Thr Lys  Leu Asn Ser Lys Arg  Val Ser Phe Lys Leu  Pro Lys Asp 
    1415                 1420                 1425             


Gln Met  Lys Val Tyr Val Asp  Asp Ile Tyr Val Ile  Pro Gln Pro 
    1430                 1435                 1440             


His Phe  Ser Thr Asp Gln Pro  Pro Leu Pro Lys Lys  Gly Gln Ser 
    1445                 1450                 1455             


Ser Ile  Asn Lys Glu Glu Val  Ile Leu Ser Lys Ala  Gly Asn Lys 
    1460                 1465                 1470             


Ser Leu  Asn Ile Ile Glu Asn  Ser Ser Ala Pro Ile  Cys Glu Asn 
    1475                 1480                 1485             


Lys Pro  Lys Ile Leu Asn Ser  Glu Glu Trp Phe Ala  Ala Ala Cys 
    1490                 1495                 1500             


Lys Lys  Glu Leu Lys Glu Asn  Ile Gln Thr Thr Asn  Tyr Asn Thr 
    1505                 1510                 1515             


Ala Leu  Asp Phe His Ser Asn  Ser Asp Val Thr Lys  Gln Val Ile 
    1520                 1525                 1530             


Gln Thr  His Val Asn Ala Gly  Glu Ala Pro Asp Pro  Val Ile Thr 
    1535                 1540                 1545             


Ser Asn  Val Pro Cys Phe His  Ser Ile Lys Pro Asn  Leu Asn Asn 
    1550                 1555                 1560             


Leu Asn  Gly Lys Thr Gly Glu  Phe Leu Ala Phe Gln  Thr Val His 
    1565                 1570                 1575             


Leu Pro  Pro Leu Pro Glu Gln  Leu Leu Glu Leu Gly  Asn Lys Ala 
    1580                 1585                 1590             


His Asn  Asp Met His Ile Val  Gln Ala Thr Glu Ile  His Asn Ile 
    1595                 1600                 1605             


Asn Ile  Ile Ser Ser Asn Ala  Lys Asp Ser Arg Asp  Glu Glu Asn 
    1610                 1615                 1620             


Lys Lys  Ser His Asn Gly Ala  Glu Thr Thr Ser Leu  Pro Pro Lys 
    1625                 1630                 1635             


Thr Val  Phe Lys Asp Lys Val  Arg Arg Cys Ser Leu  Gly Ile Phe 
    1640                 1645                 1650             


Leu Pro  Arg Leu Pro Asn Lys  Arg Asn Cys Ser Val  Thr Gly Ile 
    1655                 1660                 1665             


Asp Asp  Leu Glu Gln Ile Pro  Ala Asp Thr Thr Asp  Ile Asn His 
    1670                 1675                 1680             


Leu Glu  Thr Gln Pro Val Ser  Ser Lys Asp Ser Gly  Ile Gly Ser 
    1685                 1690                 1695             


Val Ala  Gly Lys Leu Asn Leu  Ser Pro Ser Gln Tyr  Ile Asn Glu 
    1700                 1705                 1710             


Glu Asn  Leu Pro Val Tyr Pro  Asp Glu Ile Asn Ser  Ser Asp Ser 
    1715                 1720                 1725             


Ile Asn  Ile Glu Thr Glu Glu  Lys Ala Leu Ile Glu  Thr Tyr Gln 
    1730                 1735                 1740             


Lys Glu  Ile Ser Pro Tyr Glu  Asn Lys Met Gly Lys  Thr Cys Asn 
    1745                 1750                 1755             


Ser Gln  Lys Arg Thr Trp Val  Gln Glu Glu Glu Asp  Ile His Lys 
    1760                 1765                 1770             


Glu Lys  Lys Ile Arg Lys Asn  Glu Ile Lys Phe Ser  Asp Thr Thr 
    1775                 1780                 1785             


Gln Asp  Arg Glu Ile Phe Asp  His His Thr Glu Glu  Asp Ile Asp 
    1790                 1795                 1800             


Lys Ser  Ala Asn Ser Val Leu  Ile Lys Asn Leu Ser  Arg Thr Pro 
    1805                 1810                 1815             


Ser Ser  Cys Ser Ser Ser Leu  Asp Ser Ile Lys Ala  Asp Gly Thr 
    1820                 1825                 1830             


Ser Leu  Asp Phe Ser Thr Tyr  Arg Ser Ser Gln Met  Glu Ser Gln 
    1835                 1840                 1845             


Phe Leu  Arg Asp Thr Ile Cys  Glu Glu Ser Leu Arg  Glu Lys Leu 
    1850                 1855                 1860             


Gln Asp  Gly Arg Ile Thr Ile  Arg Glu Phe Phe Ile  Leu Leu Gln 
    1865                 1870                 1875             


Val His  Ile Leu Ile Gln Lys  Pro Arg Gln Ser Asn  Leu Pro Gly 
    1880                 1885                 1890             


Asn Phe  Thr Val Asn Thr Pro  Pro Thr Pro Glu Asp  Leu Met Leu 
    1895                 1900                 1905             


Ser Gln  Tyr Val Tyr Arg Pro  Lys Ile Gln Ile Tyr  Arg Glu Asp 
    1910                 1915                 1920             


Cys Glu  Ala Arg Arg Gln Lys  Ile Glu Glu Leu Lys  Leu Ser Ala 
    1925                 1930                 1935             


Ser Asn  Gln Asp Lys Leu Leu  Val Asp Ile Asn Lys  Asn Leu Trp 
    1940                 1945                 1950             


Glu Lys  Met Arg His Cys Ser  Asp Lys Glu Leu Lys  Ala Phe Gly 
    1955                 1960                 1965             


Ile Tyr  Leu Asn Lys Ile Lys  Ser Cys Phe Thr Lys  Met Thr Lys 
    1970                 1975                 1980             


Val Phe  Thr His Gln Gly Lys  Val Ala Leu Tyr Gly  Lys Leu Val 
    1985                 1990                 1995             


Gln Ser  Ala Gln Asn Glu Arg  Glu Lys Leu Gln Ile  Lys Ile Asp 
    2000                 2005                 2010             


Glu Met  Asp Lys Ile Leu Lys  Lys Ile Asp Asn Cys  Leu Thr Glu 
    2015                 2020                 2025             


Met Glu  Thr Glu Thr Lys Asn  Leu Glu Asp Glu Glu  Lys Asn Asn 
    2030                 2035                 2040             


Pro Val  Glu Glu Trp Asp Ser  Glu Met Arg Ala Ala  Glu Lys Glu 
    2045                 2050                 2055             


Leu Glu  Gln Leu Lys Thr Glu  Glu Glu Glu Leu Gln  Arg Asn Leu 
    2060                 2065                 2070             


Leu Glu  Leu Glu Val Gln Lys  Glu Gln Thr Leu Ala  Gln Ile Asp 
    2075                 2080                 2085             


Phe Met  Gln Lys Gln Arg Asn  Arg Thr Glu Glu Leu  Leu Asp Gln 
    2090                 2095                 2100             


Leu Ser  Leu Ser Glu Trp Asp  Val Val Glu Trp Ser  Asp Asp Gln 
    2105                 2110                 2115             


Ala Val  Phe Thr Phe Val Tyr  Asp Thr Ile Gln Leu  Thr Ile Thr 
    2120                 2125                 2130             


Phe Glu  Glu Ser Val Val Gly  Phe Pro Phe Leu Asp  Lys Arg Tyr 
    2135                 2140                 2145             


Arg Lys  Ile Val Asp Val Asn  Phe Gln Ser Leu Leu  Asp Glu Asp 
    2150                 2155                 2160             


Gln Ala  Pro Pro Ser Ser Leu  Leu Val His Lys Leu  Ile Phe Gln 
    2165                 2170                 2175             


Tyr Val  Glu Glu Lys Glu Ser  Trp Lys Lys Thr Cys  Thr Thr Gln 
    2180                 2185                 2190             


His Gln  Leu Pro Lys Met Leu  Glu Glu Phe Ser Leu  Val Val His 
    2195                 2200                 2205             


His Cys  Arg Leu Leu Gly Glu  Glu Ile Glu Tyr Leu  Lys Arg Trp 
    2210                 2215                 2220             


Gly Pro  Asn Tyr Asn Leu Met  Asn Ile Asp Ile Asn  Asn Asn Glu 
    2225                 2230                 2235             


Leu Arg  Leu Leu Phe Ser Ser  Ser Ala Ala Phe Ala  Lys Phe Glu 
    2240                 2245                 2250             


Ile Thr  Leu Phe Leu Ser Ala  Tyr Tyr Pro Ser Val  Pro Leu Pro 
    2255                 2260                 2265             


Ser Thr  Ile Gln Asn His Val  Gly Asn Thr Ser Gln  Asp Asp Ile 
    2270                 2275                 2280             


Ala Thr  Ile Leu Ser Lys Val  Pro Leu Glu Asn Asn  Tyr Leu Lys 
    2285                 2290                 2295             


Asn Val  Val Lys Gln Ile Tyr  Gln Asp Leu Phe Gln  Asp Cys His 
    2300                 2305                 2310             


Phe Tyr  His 
    2315     


<210>  1602
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASD1__Homo_sapiens__NP_075051

<400>  1602

Met Ala Ala Leu Ala Tyr Asn Leu Gly Lys Arg Glu Ile Asn His Tyr 
1               5                   10                  15      


Phe Ser Val Arg Ser Ala Lys Val Leu Ala Leu Val Ala Val Leu Leu 
            20                  25                  30          


Leu Ala Ala Cys His Leu Ala Ser Arg Arg Tyr Arg Gly Asn Asp Ser 
        35                  40                  45              


Cys Glu Tyr Leu Leu Ser Ser Gly Arg Phe Leu Gly Glu Lys Val Trp 
    50                  55                  60                  


Gln Pro His Ser Cys Met Met His Lys Tyr Lys Ile Ser Glu Ala Lys 
65                  70                  75                  80  


Asn Cys Leu Val Asp Lys His Ile Ala Phe Ile Gly Asp Ser Arg Ile 
                85                  90                  95      


Arg Gln Leu Phe Tyr Ser Phe Val Lys Ile Ile Asn Pro Gln Phe Lys 
            100                 105                 110         


Glu Glu Gly Asn Lys His Glu Asn Ile Pro Phe Glu Asp Lys Thr Ala 
        115                 120                 125             


Ser Val Lys Val Asp Phe Leu Trp His Pro Glu Val Asn Gly Ser Met 
    130                 135                 140                 


Lys Gln Cys Ile Lys Val Trp Thr Glu Asp Ser Ile Ala Lys Pro His 
145                 150                 155                 160 


Val Ile Val Ala Gly Ala Ala Thr Trp Ser Ile Lys Ile His Asn Gly 
                165                 170                 175     


Ser Ser Glu Ala Leu Ser Gln Tyr Lys Met Asn Ile Thr Ser Ile Ala 
            180                 185                 190         


Pro Leu Leu Glu Lys Leu Ala Lys Thr Ser Asp Val Tyr Trp Val Leu 
        195                 200                 205             


Gln Asp Pro Val Tyr Glu Asp Leu Leu Ser Glu Asn Arg Lys Met Ile 
    210                 215                 220                 


Thr Asn Glu Lys Ile Asp Ala Tyr Asn Glu Ala Ala Val Ser Ile Leu 
225                 230                 235                 240 


Asn Ser Ser Thr Arg Asn Ser Lys Ser Asn Val Lys Met Phe Ser Val 
                245                 250                 255     


Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser Leu Asp Gly Leu 
            260                 265                 270         


His Leu Pro Glu Ser Ser Arg Glu Thr Thr Ala Met Ile Leu Met Asn 
        275                 280                 285             


Val Tyr Cys Asn Lys Ile Leu Lys Pro Val Asp Gly Ser Cys Cys Gln 
    290                 295                 300                 


Pro Arg Pro Pro Val Thr Leu Ile Gln Lys Leu Ala Ala Cys Phe Phe 
305                 310                 315                 320 


Thr Leu Ser Ile Ile Gly Tyr Leu Ile Phe Tyr Ile Ile His Arg Asn 
                325                 330                 335     


Ala His Arg Lys Asn Lys Pro Cys Thr Asp Leu Glu Ser Gly Glu Glu 
            340                 345                 350         


Lys Lys Asn Ile Ile Asn Thr Pro Val Ser Ser Leu Glu Ile Leu Leu 
        355                 360                 365             


Gln Ser Phe Cys Lys Leu Gly Leu Ile Met Ala Tyr Phe Tyr Met Cys 
    370                 375                 380                 


Asp Arg Ala Asn Leu Phe Met Lys Glu Asn Lys Phe Tyr Thr His Ser 
385                 390                 395                 400 


Ser Phe Phe Ile Pro Ile Ile Tyr Ile Leu Val Leu Gly Val Phe Tyr 
                405                 410                 415     


Asn Glu Asn Thr Lys Glu Thr Lys Val Leu Asn Arg Glu Gln Thr Asp 
            420                 425                 430         


Glu Trp Lys Gly Trp Met Gln Leu Val Ile Leu Ile Tyr His Ile Ser 
        435                 440                 445             


Gly Ala Ser Thr Phe Leu Pro Val Tyr Met His Ile Arg Val Leu Val 
    450                 455                 460                 


Ala Ala Tyr Leu Phe Gln Thr Gly Tyr Gly His Phe Ser Tyr Phe Trp 
465                 470                 475                 480 


Ile Lys Gly Asp Phe Gly Ile Tyr Arg Val Cys Gln Val Leu Phe Arg 
                485                 490                 495     


Leu Asn Phe Leu Val Val Val Leu Cys Ile Val Met Asp Arg Pro Tyr 
            500                 505                 510         


Gln Phe Tyr Tyr Phe Val Pro Leu Val Thr Val Trp Phe Met Val Ile 
        515                 520                 525             


Tyr Val Thr Leu Ala Leu Trp Pro Gln Ile Ile Gln Lys Lys Ala Asn 
    530                 535                 540                 


Gly Asn Cys Phe Trp His Phe Gly Leu Leu Leu Lys Leu Gly Phe Leu 
545                 550                 555                 560 


Leu Leu Phe Ile Cys Phe Leu Ala Tyr Ser Gln Gly Ala Phe Glu Lys 
                565                 570                 575     


Ile Phe Ser Leu Trp Pro Leu Ser Lys Cys Phe Glu Leu Lys Gly Asn 
            580                 585                 590         


Val Tyr Glu Trp Trp Phe Arg Trp Arg Leu Asp Arg Tyr Val Val Phe 
        595                 600                 605             


His Gly Met Leu Phe Ala Phe Ile Tyr Leu Ala Leu Gln Lys Arg Gln 
    610                 615                 620                 


Ile Leu Ser Glu Gly Lys Gly Glu Pro Leu Phe Ser Asn Lys Ile Ser 
625                 630                 635                 640 


Asn Phe Leu Leu Phe Ile Ser Val Val Ser Phe Leu Thr Tyr Ser Ile 
                645                 650                 655     


Trp Ala Ser Ser Cys Lys Asn Lys Ala Glu Cys Asn Glu Leu His Pro 
            660                 665                 670         


Ser Val Ser Val Val Gln Ile Leu Ala Phe Ile Leu Ile Arg Asn Ile 
        675                 680                 685             


Pro Gly Tyr Ala Arg Ser Val Tyr Ser Ser Phe Phe Ala Trp Phe Gly 
    690                 695                 700                 


Lys Ile Ser Leu Glu Leu Phe Ile Cys Gln Tyr His Ile Trp Leu Ala 
705                 710                 715                 720 


Ala Asp Thr Arg Gly Ile Leu Val Leu Ile Pro Gly Asn Pro Met Leu 
                725                 730                 735     


Asn Ile Ile Val Ser Thr Phe Ile Phe Val Cys Val Ala His Glu Ile 
            740                 745                 750         


Ser Gln Ile Thr Asn Asp Leu Ala Gln Ile Ile Ile Pro Lys Asp Asn 
        755                 760                 765             


Ser Ser Leu Leu Lys Arg Leu Ala Cys Ile Ala Ala Phe Phe Cys Gly 
    770                 775                 780                 


Leu Leu Ile Leu Ser Ser Ile Gln Asp Lys Ser Lys His 
785                 790                 795         


<210>  1603
<211>  898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASK__Homo_sapiens__NP_001119526

<400>  1603

Met Ala Asp Asp Asp Val Leu Phe Glu Asp Val Tyr Glu Leu Cys Glu 
1               5                   10                  15      


Val Ile Gly Lys Gly Pro Phe Ser Val Val Arg Arg Cys Ile Asn Arg 
            20                  25                  30          


Glu Thr Gly Gln Gln Phe Ala Val Lys Ile Val Asp Val Ala Lys Phe 
        35                  40                  45              


Thr Ser Ser Pro Gly Leu Ser Thr Glu Asp Leu Lys Arg Glu Ala Ser 
    50                  55                  60                  


Ile Cys His Met Leu Lys His Pro His Ile Val Glu Leu Leu Glu Thr 
65                  70                  75                  80  


Tyr Ser Ser Asp Gly Met Leu Tyr Met Val Phe Glu Phe Met Asp Gly 
                85                  90                  95      


Ala Asp Leu Cys Phe Glu Ile Val Lys Arg Ala Asp Ala Gly Phe Val 
            100                 105                 110         


Tyr Ser Glu Ala Val Ala Ser His Tyr Met Arg Gln Ile Leu Glu Ala 
        115                 120                 125             


Leu Arg Tyr Cys His Asp Asn Asn Ile Ile His Arg Asp Val Lys Pro 
    130                 135                 140                 


His Cys Val Leu Leu Ala Ser Lys Glu Asn Ser Ala Pro Val Lys Leu 
145                 150                 155                 160 


Gly Gly Phe Gly Val Ala Ile Gln Leu Gly Glu Ser Gly Leu Val Ala 
                165                 170                 175     


Gly Gly Arg Val Gly Thr Pro His Phe Met Ala Pro Glu Val Val Lys 
            180                 185                 190         


Arg Glu Pro Tyr Gly Lys Pro Val Asp Val Trp Gly Cys Gly Val Ile 
        195                 200                 205             


Leu Phe Ile Leu Leu Ser Gly Cys Leu Pro Phe Tyr Gly Thr Lys Glu 
    210                 215                 220                 


Arg Leu Phe Glu Gly Ile Ile Lys Gly Lys Tyr Lys Met Asn Pro Arg 
225                 230                 235                 240 


Gln Trp Ser His Ile Ser Glu Ser Ala Lys Asp Leu Val Arg Arg Met 
                245                 250                 255     


Leu Met Leu Asp Pro Ala Glu Arg Ile Thr Val Tyr Glu Ala Leu Asn 
            260                 265                 270         


His Pro Trp Leu Lys Glu Arg Asp Arg Tyr Ala Tyr Lys Ile His Leu 
        275                 280                 285             


Pro Glu Thr Val Glu Gln Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu 
    290                 295                 300                 


Lys Gly Ala Val Leu Ala Ala Val Ser Ser His Lys Phe Asn Ser Phe 
305                 310                 315                 320 


Tyr Gly Asp Pro Pro Glu Glu Leu Pro Asp Phe Ser Glu Asp Pro Thr 
                325                 330                 335     


Ser Ser Gly Leu Leu Ala Ala Glu Arg Ala Val Ser Gln Val Leu Asp 
            340                 345                 350         


Ser Leu Glu Glu Ile His Ala Leu Thr Asp Cys Ser Glu Lys Asp Leu 
        355                 360                 365             


Asp Phe Leu His Ser Val Phe Gln Asp Gln His Leu His Thr Leu Leu 
    370                 375                 380                 


Asp Leu Tyr Asp Lys Ile Asn Thr Lys Ser Ser Pro Gln Ile Arg Asn 
385                 390                 395                 400 


Pro Pro Ser Asp Ala Val Gln Arg Ala Lys Glu Val Leu Glu Glu Ile 
                405                 410                 415     


Ser Cys Tyr Pro Glu Asn Asn Asp Ala Lys Glu Leu Lys Arg Ile Leu 
            420                 425                 430         


Thr Gln Pro His Phe Met Ala Leu Leu Gln Thr His Asp Val Val Ala 
        435                 440                 445             


His Glu Val Tyr Ser Asp Glu Ala Leu Arg Val Thr Pro Pro Pro Thr 
    450                 455                 460                 


Ser Pro Tyr Leu Asn Gly Asp Ser Pro Glu Ser Ala Asn Gly Asp Met 
465                 470                 475                 480 


Asp Met Glu Asn Val Thr Arg Val Arg Leu Val Gln Phe Gln Lys Asn 
                485                 490                 495     


Thr Asp Glu Pro Met Gly Ile Thr Leu Lys Met Asn Glu Leu Asn His 
            500                 505                 510         


Cys Ile Val Ala Arg Ile Met His Gly Gly Met Ile His Arg Gln Gly 
        515                 520                 525             


Thr Leu His Val Gly Asp Glu Ile Arg Glu Ile Asn Gly Ile Ser Val 
    530                 535                 540                 


Ala Asn Gln Thr Val Glu Gln Leu Gln Lys Met Leu Arg Glu Met Arg 
545                 550                 555                 560 


Gly Ser Ile Thr Phe Lys Ile Val Pro Ser Tyr Arg Thr Gln Ser Ser 
                565                 570                 575     


Ser Cys Glu Asp Leu Pro Ser Thr Thr Gln Pro Lys Gly Arg Gln Ile 
            580                 585                 590         


Tyr Val Arg Ala Gln Phe Glu Tyr Asp Pro Ala Lys Asp Asp Leu Ile 
        595                 600                 605             


Pro Cys Lys Glu Ala Gly Ile Arg Phe Arg Val Gly Asp Ile Ile Gln 
    610                 615                 620                 


Ile Ile Ser Lys Asp Asp His Asn Trp Trp Gln Gly Lys Leu Glu Asn 
625                 630                 635                 640 


Ser Lys Asn Gly Thr Ala Gly Leu Ile Pro Ser Pro Glu Leu Gln Glu 
                645                 650                 655     


Trp Arg Val Ala Cys Ile Ala Met Glu Lys Thr Lys Gln Glu Gln Gln 
            660                 665                 670         


Ala Ser Cys Thr Trp Phe Gly Lys Lys Lys Lys Gln Tyr Lys Asp Lys 
        675                 680                 685             


Tyr Leu Ala Lys His Asn Ala Asp Leu Val Thr Tyr Glu Glu Val Val 
    690                 695                 700                 


Lys Leu Pro Ala Phe Lys Arg Lys Thr Leu Val Leu Leu Gly Ala His 
705                 710                 715                 720 


Gly Val Gly Arg Arg His Ile Lys Asn Thr Leu Ile Thr Lys His Pro 
                725                 730                 735     


Asp Arg Phe Ala Tyr Pro Ile Pro His Thr Thr Arg Pro Pro Lys Lys 
            740                 745                 750         


Asp Glu Glu Asn Gly Lys Asn Tyr Tyr Phe Val Ser His Asp Gln Met 
        755                 760                 765             


Met Gln Asp Ile Ser Asn Asn Glu Tyr Leu Glu Tyr Gly Ser His Glu 
    770                 775                 780                 


Asp Ala Met Tyr Gly Thr Lys Leu Glu Thr Ile Arg Lys Ile His Glu 
785                 790                 795                 800 


Gln Gly Leu Ile Ala Ile Leu Asp Val Glu Pro Gln Ala Leu Lys Val 
                805                 810                 815     


Leu Arg Thr Ala Glu Phe Ala Pro Phe Val Val Phe Ile Ala Ala Pro 
            820                 825                 830         


Thr Ile Thr Pro Gly Leu Asn Glu Asp Glu Ser Leu Gln Arg Leu Gln 
        835                 840                 845             


Lys Glu Ser Asp Ile Leu Gln Arg Thr Tyr Ala His Tyr Phe Asp Leu 
    850                 855                 860                 


Thr Ile Ile Asn Asn Glu Ile Asp Glu Thr Ile Arg His Leu Glu Glu 
865                 870                 875                 880 


Ala Val Glu Leu Val Cys Thr Ala Pro Gln Trp Val Pro Val Ser Trp 
                885                 890                 895     


Val Tyr 
        


<210>  1604
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP10__Homo_sapiens__NP_001193453

<400>  1604

Met Lys Ser Gln Gly Gln His Trp Tyr Ser Ser Ser Asp Lys Asn Cys 
1               5                   10                  15      


Lys Val Ser Phe Arg Glu Lys Leu Leu Ile Ile Asp Ser Asn Leu Gly 
            20                  25                  30          


Val Gln Asp Val Glu Asn Leu Lys Phe Leu Cys Ile Gly Leu Val Pro 
        35                  40                  45              


Asn Lys Lys Leu Glu Lys Ser Ser Ser Ala Ser Asp Val Phe Glu His 
    50                  55                  60                  


Leu Leu Ala Glu Asp Leu Leu Ser Glu Glu Asp Pro Phe Phe Leu Ala 
65                  70                  75                  80  


Glu Leu Leu Tyr Ile Ile Arg Gln Lys Lys Leu Leu Gln His Leu Asn 
                85                  90                  95      


Cys Thr Lys Glu Glu Val Glu Arg Leu Leu Pro Thr Arg Gln Arg Val 
            100                 105                 110         


Ser Leu Phe Arg Asn Leu Leu Tyr Glu Leu Ser Glu Gly Ile Asp Ser 
        115                 120                 125             


Glu Asn Leu Lys Asp Met Ile Phe Leu Leu Lys Asp Ser Leu Pro Lys 
    130                 135                 140                 


Thr Glu Met Thr Ser Leu Ser Phe Leu Ala Phe Leu Glu Lys Gln Gly 
145                 150                 155                 160 


Lys Ile Asp Glu Asp Asn Leu Thr Cys Leu Glu Asp Leu Cys Lys Thr 
                165                 170                 175     


Val Val Pro Lys Leu Leu Arg Asn Ile Glu Lys Tyr Lys Arg Glu Lys 
            180                 185                 190         


Ala Ile Gln Ile Val Thr Pro Pro Val Asp Lys Glu Ala Glu Ser Tyr 
        195                 200                 205             


Gln Gly Glu Glu Glu Leu Val Ser Gln Thr Asp Val Lys Thr Phe Leu 
    210                 215                 220                 


Glu Ala Leu Pro Gln Glu Ser Trp Gln Asn Lys His Ala Gly Ser Asn 
225                 230                 235                 240 


Glu Ile Leu Ser His Val Phe Gln Trp Leu Gly Phe Thr Val His Ile 
                245                 250                 255     


His Asn Asn Val Thr Lys Val Glu Met Glu Met Val Leu Gln Lys Gln 
            260                 265                 270         


Lys Cys Asn Pro Ala His Ala Asp Gly Asp Cys Phe Val Phe Cys Ile 
        275                 280                 285             


Leu Thr His Gly Arg Phe Gly Ala Val Tyr Ser Ser Asp Glu Ala Leu 
    290                 295                 300                 


Ile Pro Ile Arg Glu Ile Met Ser His Phe Thr Ala Leu Gln Cys Pro 
305                 310                 315                 320 


Arg Leu Ala Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gln Gly 
                325                 330                 335     


Glu Glu Ile Gln Pro Ser Val Ser Ile Glu Ala Asp Ala Leu Asn Pro 
            340                 345                 350         


Glu Gln Ala Pro Thr Ser Leu Gln Asp Ser Ile Pro Ala Glu Ala Asp 
        355                 360                 365             


Phe Leu Leu Gly Leu Ala Thr Val Pro Gly Tyr Val Ser Phe Arg His 
    370                 375                 380                 


Val Glu Glu Gly Ser Trp Tyr Ile Gln Ser Leu Cys Asn His Leu Lys 
385                 390                 395                 400 


Lys Leu Val Pro Arg His Glu Asp Ile Leu Ser Ile Leu Thr Ala Val 
                405                 410                 415     


Asn Asp Asp Val Ser Arg Arg Val Asp Lys Gln Gly Thr Lys Lys Gln 
            420                 425                 430         


Met Pro Gln Pro Ala Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Val 
        435                 440                 445             


Pro Leu Asp Ala Leu Ser Leu 
    450                 455 


<210>  1605
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP14__Homo_sapiens__NP_036246

<400>  1605

Met Ser Asn Pro Arg Ser Leu Glu Glu Glu Lys Tyr Asp Met Ser Gly 
1               5                   10                  15      


Ala Arg Leu Ala Leu Ile Leu Cys Val Thr Lys Ala Arg Glu Gly Ser 
            20                  25                  30          


Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe Arg Gln Leu Arg Phe 
        35                  40                  45              


Glu Ser Thr Met Lys Arg Asp Pro Thr Ala Glu Gln Phe Gln Glu Glu 
    50                  55                  60                  


Leu Glu Lys Phe Gln Gln Ala Ile Asp Ser Arg Glu Asp Pro Val Ser 
65                  70                  75                  80  


Cys Ala Phe Val Val Leu Met Ala His Gly Arg Glu Gly Phe Leu Lys 
                85                  90                  95      


Gly Glu Asp Gly Glu Met Val Lys Leu Glu Asn Leu Phe Glu Ala Leu 
            100                 105                 110         


Asn Asn Lys Asn Cys Gln Ala Leu Arg Ala Lys Pro Lys Val Tyr Ile 
        115                 120                 125             


Ile Gln Ala Cys Arg Gly Glu Gln Arg Asp Pro Gly Glu Thr Val Gly 
    130                 135                 140                 


Gly Asp Glu Ile Val Met Val Ile Lys Asp Ser Pro Gln Thr Ile Pro 
145                 150                 155                 160 


Thr Tyr Thr Asp Ala Leu His Val Tyr Ser Thr Val Glu Gly Tyr Ile 
                165                 170                 175     


Ala Tyr Arg His Asp Gln Lys Gly Ser Cys Phe Ile Gln Thr Leu Val 
            180                 185                 190         


Asp Val Phe Thr Lys Arg Lys Gly His Ile Leu Glu Leu Leu Thr Glu 
        195                 200                 205             


Val Thr Arg Arg Met Ala Glu Ala Glu Leu Val Gln Glu Gly Lys Ala 
    210                 215                 220                 


Arg Lys Thr Asn Pro Glu Ile Gln Ser Thr Leu Arg Lys Arg Leu Tyr 
225                 230                 235                 240 


Leu Gln 
        


<210>  1606
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP1__Homo_sapiens__NP_001244048

<400>  1606

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Ala Pro Gln Ala Val 
                85                  90                  95      


Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val 
            100                 105                 110         


Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser 
        115                 120                 125             


Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala 
    130                 135                 140                 


Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly 
145                 150                 155                 160 


Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly 
                165                 170                 175     


Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr 
            180                 185                 190         


Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser 
        195                 200                 205             


Thr Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly 
    210                 215                 220                 


Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile 
225                 230                 235                 240 


Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro 
                245                 250                 255     


Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val 
            260                 265                 270         


Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Thr 
        275                 280                 285             


Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys 
    290                 295                 300                 


Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val Ser Trp Arg 
305                 310                 315                 320 


His Pro Thr Met Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met 
                325                 330                 335     


Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Val 
            340                 345                 350         


Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala Gln Met Pro Thr Thr 
        355                 360                 365             


Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu Phe Pro Gly His 
    370                 375                 380             


<210>  1607
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP2__Homo_sapiens__NP_001215

<400>  1607

Met His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu 
1               5                   10                  15      


Ala Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys 
            20                  25                  30          


Asp Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly 
        35                  40                  45              


Ser Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly 
    50                  55                  60                  


Pro Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln 
65                  70                  75                  80  


Gly His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His 
                85                  90                  95      


Val Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro 
            100                 105                 110         


Val Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp 
        115                 120                 125             


Thr Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln 
    130                 135                 140                 


Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala 
145                 150                 155                 160 


Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn 
                165                 170                 175     


Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp 
            180                 185                 190         


Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp 
        195                 200                 205             


Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu 
    210                 215                 220                 


Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile 
225                 230                 235                 240 


Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp 
                245                 250                 255     


Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala 
            260                 265                 270         


Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala 
        275                 280                 285             


Cys Arg Gly Gly Ala Ile Gly Ser Leu Gly His Leu Leu Leu Phe Thr 
    290                 295                 300                 


Ala Ala Thr Ala Ser Leu Ala Leu 
305                 310         


<210>  1608
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP3__Homo_sapiens__XP_011530603

<400>  1608

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  1609
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP4__Homo_sapiens__NP_001216

<400>  1609

Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Glu Ser 
1               5                   10                  15      


Leu Gly Lys Asp Phe Leu Thr Gly Val Leu Asp Asn Leu Val Glu Gln 
            20                  25                  30          


Asn Val Leu Asn Trp Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Ala 
        35                  40                  45              


Lys Thr Glu Asp Lys Val Arg Val Met Ala Asp Ser Met Gln Glu Lys 
    50                  55                  60                  


Gln Arg Met Ala Gly Gln Met Leu Leu Gln Thr Phe Phe Asn Ile Asp 
65                  70                  75                  80  


Gln Ile Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro 
                85                  90                  95      


Pro Glu Ser Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro His Glu 
            100                 105                 110         


Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile 
        115                 120                 125             


Lys Glu Arg Asn Asn Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr 
    130                 135                 140                 


Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe Asp Ile Thr 
145                 150                 155                 160 


Gly Met Lys Glu Leu Leu Glu Gly Leu Asp Tyr Ser Val Asp Val Glu 
                165                 170                 175     


Glu Asn Leu Thr Ala Arg Asp Met Glu Ser Ala Leu Arg Ala Phe Ala 
            180                 185                 190         


Thr Arg Pro Glu His Lys Ser Ser Asp Ser Thr Phe Leu Val Leu Met 
        195                 200                 205             


Ser His Gly Ile Leu Glu Gly Ile Cys Gly Thr Val His Asp Glu Lys 
    210                 215                 220                 


Lys Pro Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn 
225                 230                 235                 240 


Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln 
                245                 250                 255     


Ala Cys Arg Gly Ala Asn Arg Gly Glu Leu Trp Val Arg Asp Ser Pro 
            260                 265                 270         


Ala Ser Leu Glu Val Ala Ser Ser Gln Ser Ser Glu Asn Leu Glu Glu 
        275                 280                 285             


Asp Ala Val Tyr Lys Thr His Val Glu Lys Asp Phe Ile Ala Phe Cys 
    290                 295                 300                 


Ser Ser Thr Pro His Asn Val Ser Trp Arg Asp Ser Thr Met Gly Ser 
305                 310                 315                 320 


Ile Phe Ile Thr Gln Leu Ile Thr Cys Phe Gln Lys Tyr Ser Trp Cys 
                325                 330                 335     


Cys His Leu Glu Glu Val Phe Arg Lys Val Gln Gln Ser Phe Glu Thr 
            340                 345                 350         


Pro Arg Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Leu Ser Met Thr 
        355                 360                 365             


Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    370                 375         


<210>  1610
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP5__Homo_sapiens__NP_001129581

<400>  1610

Met Ala Glu Asp Asn His Lys Lys Lys Thr Val Lys Met Leu Glu Tyr 
1               5                   10                  15      


Leu Gly Lys Asp Val Leu His Gly Val Phe Asn Tyr Leu Ala Lys His 
            20                  25                  30          


Asp Val Leu Thr Leu Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Thr 
        35                  40                  45              


Lys Ile Glu Asp Lys Ala Leu Ile Leu Val Asp Ser Leu Arg Lys Asn 
    50                  55                  60                  


Arg Val Ala His Gln Met Phe Thr Gln Thr Leu Leu Asn Met Asp Gln 
65                  70                  75                  80  


Lys Ile Thr Ser Val Lys Pro Leu Leu Gln Ile Glu Ala Gly Pro Pro 
                85                  90                  95      


Glu Ser Ala Glu Ser Thr Asn Ile Leu Lys Leu Cys Pro Arg Glu Glu 
            100                 105                 110         


Phe Leu Arg Leu Cys Lys Lys Asn His Asp Glu Ile Tyr Pro Ile Lys 
        115                 120                 125             


Lys Arg Glu Asp Arg Arg Arg Leu Ala Leu Ile Ile Cys Asn Thr Lys 
    130                 135                 140                 


Phe Asp His Leu Pro Ala Arg Asn Gly Ala His Tyr Asp Ile Val Gly 
145                 150                 155                 160 


Met Lys Arg Leu Leu Gln Gly Leu Gly Tyr Thr Val Val Asp Glu Lys 
                165                 170                 175     


Asn Leu Thr Ala Arg Asp Met Glu Ser Val Leu Arg Ala Phe Ala Ala 
            180                 185                 190         


Arg Pro Glu His Lys Ser Ser Asp Ser Thr Phe Leu Val Leu Met Ser 
        195                 200                 205             


His Gly Ile Leu Glu Gly Ile Cys Gly Thr Ala His Lys Lys Lys Lys 
    210                 215                 220                 


Pro Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn Arg 
225                 230                 235                 240 


Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln Ala 
                245                 250                 255     


Cys Arg Gly Glu Lys His Gly Glu Leu Trp Val Arg Asp Ser Pro Ala 
            260                 265                 270         


Ser Leu Ala Leu Ile Ser Ser Gln Ser Ser Glu Asn Leu Glu Ala Asp 
        275                 280                 285             


Ser Val Cys Lys Ile His Glu Glu Lys Asp Phe Ile Ala Phe Cys Ser 
    290                 295                 300                 


Ser Thr Pro His Asn Val Ser Trp Arg Asp Arg Thr Arg Gly Ser Ile 
305                 310                 315                 320 


Phe Ile Thr Glu Leu Ile Thr Cys Phe Gln Lys Tyr Ser Cys Cys Cys 
                325                 330                 335     


His Leu Met Glu Ile Phe Arg Lys Val Gln Lys Ser Phe Glu Val Pro 
            340                 345                 350         


Gln Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Ala Thr Leu Thr Arg 
        355                 360                 365             


Asp Phe Tyr Leu Phe Pro Gly Asn 
    370                 375     


<210>  1611
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP6__Homo_sapiens__NP_001217

<400>  1611

Met Ser Ser Ala Ser Gly Leu Arg Arg Gly His Pro Ala Gly Gly Glu 
1               5                   10                  15      


Glu Asn Met Thr Glu Thr Asp Ala Phe Tyr Lys Arg Glu Met Phe Asp 
            20                  25                  30          


Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg Arg Gly Ile Ala Leu 
        35                  40                  45              


Ile Phe Asn His Glu Arg Phe Phe Trp His Leu Thr Leu Pro Glu Arg 
    50                  55                  60                  


Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr Arg Arg Phe Ser Asp 
65                  70                  75                  80  


Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu Lys Ala Glu Glu Leu 
                85                  90                  95      


Leu Leu Lys Ile His Glu Val Ser Thr Val Ser His Ala Asp Ala Asp 
            100                 105                 110         


Cys Phe Val Cys Val Phe Leu Ser His Gly Glu Gly Asn His Ile Tyr 
        115                 120                 125             


Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu Thr Gly Leu Phe Lys 
    130                 135                 140                 


Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro Lys Ile Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Asn Gln His Asp Val Pro Val Ile Pro Leu Asp 
                165                 170                 175     


Val Val Asp Asn Gln Thr Glu Lys Leu Asp Thr Asn Ile Thr Glu Val 
            180                 185                 190         


Asp Ala Ala Ser Val Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met 
        195                 200                 205             


Cys Tyr Ser Val Ala Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn 
    210                 215                 220                 


Gly Ser Trp Tyr Ile Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly 
225                 230                 235                 240 


Ser Ser Leu Glu Phe Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val 
                245                 250                 255     


Ser Gln Arg Arg Val Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys 
            260                 265                 270         


Lys Gln Val Pro Cys Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe 
        275                 280                 285             


Phe Pro Lys Ser Asn 
    290             


<210>  1612
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP7__Homo_sapiens__NP_001218

<400>  1612

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  1613
<211>  1982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP8AP2__Homo_sapiens__NP_001131140

<400>  1613

Met Ala Ala Asp Asp Asp Asn Gly Asp Gly Thr Ser Leu Phe Asp Val 
1               5                   10                  15      


Phe Ser Ala Ser Pro Leu Lys Asn Asn Asp Glu Gly Ser Leu Asp Ile 
            20                  25                  30          


Tyr Ala Gly Leu Asp Ser Ala Val Ser Asp Ser Ala Ser Lys Ser Cys 
        35                  40                  45              


Val Pro Ser Arg Asn Cys Leu Asp Leu Tyr Glu Glu Ile Leu Thr Glu 
    50                  55                  60                  


Glu Gly Thr Ala Lys Glu Ala Thr Tyr Asn Asp Leu Gln Val Glu Tyr 
65                  70                  75                  80  


Gly Lys Cys Gln Leu Gln Met Lys Glu Leu Met Lys Lys Phe Lys Glu 
                85                  90                  95      


Ile Gln Thr Gln Asn Phe Ser Leu Ile Asn Glu Asn Gln Ser Leu Lys 
            100                 105                 110         


Lys Asn Ile Ser Ala Leu Ile Lys Thr Ala Arg Val Glu Ile Asn Arg 
        115                 120                 125             


Lys Asp Glu Glu Ile Ser Asn Leu His Gln Arg Leu Ser Glu Phe Pro 
    130                 135                 140                 


His Phe Arg Asn Asn His Lys Thr Ala Arg Thr Phe Asp Thr Val Lys 
145                 150                 155                 160 


Thr Lys Asp Leu Lys Ser Arg Ser Pro His Leu Asp Asp Cys Ser Lys 
                165                 170                 175     


Thr Asp His Arg Ala Lys Ser Asp Val Ser Lys Asp Val His His Ser 
            180                 185                 190         


Thr Ser Leu Pro Asn Leu Glu Lys Glu Gly Lys Pro His Ser Asp Lys 
        195                 200                 205             


Arg Ser Thr Ser His Leu Pro Thr Ser Val Glu Lys His Cys Thr Asn 
    210                 215                 220                 


Gly Val Trp Ser Arg Ser His Tyr Gln Val Gly Glu Gly Ser Ser Asn 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Gly Arg Lys Asp Ile Arg His Ser Gln Phe Asn 
                245                 250                 255     


Arg Gly Thr Glu Arg Val Arg Lys Asp Leu Ser Thr Gly Cys Gly Asp 
            260                 265                 270         


Gly Glu Pro Arg Ile Leu Glu Ala Ser Gln Arg Leu Gln Gly His Pro 
        275                 280                 285             


Glu Lys Tyr Gly Lys Gly Glu Pro Lys Thr Glu Ser Lys Ser Ser Lys 
    290                 295                 300                 


Phe Lys Ser Asn Ser Asp Ser Asp Tyr Lys Gly Glu Arg Ile Asn Ser 
305                 310                 315                 320 


Ser Trp Glu Lys Glu Thr Pro Gly Glu Arg Ser His Ser Arg Val Asp 
                325                 330                 335     


Ser Gln Ser Asp Lys Lys Leu Glu Arg Gln Ser Glu Arg Ser Gln Asn 
            340                 345                 350         


Ile Asn Arg Lys Glu Val Lys Ser Gln Asp Lys Glu Glu Arg Lys Val 
        355                 360                 365             


Asp Gln Lys Pro Lys Ser Val Val Lys Asp Gln Asp His Trp Arg Arg 
    370                 375                 380                 


Ser Glu Arg Ala Ser Leu Pro His Ser Lys Asn Glu Ile Thr Phe Ser 
385                 390                 395                 400 


His Asn Ser Ser Lys Tyr His Leu Glu Glu Arg Arg Gly Trp Glu Asp 
                405                 410                 415     


Cys Lys Arg Asp Lys Ser Val Asn Ser His Ser Phe Gln Asp Gly Arg 
            420                 425                 430         


Cys Pro Ser Ser Leu Ser Asn Ser Arg Thr His Lys Asn Ile Asp Ser 
        435                 440                 445             


Lys Glu Val Asp Ala Met His Gln Trp Glu Asn Thr Pro Leu Lys Ala 
    450                 455                 460                 


Glu Arg His Arg Thr Glu Asp Lys Arg Lys Arg Glu Gln Glu Ser Lys 
465                 470                 475                 480 


Glu Glu Asn Arg His Ile Arg Asn Glu Lys Arg Val Pro Thr Glu His 
                485                 490                 495     


Leu Gln Lys Thr Asn Lys Glu Thr Lys Lys Thr Thr Thr Asp Leu Lys 
            500                 505                 510         


Lys Gln Asn Glu Pro Lys Thr Asp Lys Gly Glu Val Leu Asp Asn Gly 
        515                 520                 525             


Val Ser Glu Gly Ala Asp Asn Lys Glu Leu Ala Met Lys Ala Glu Ser 
    530                 535                 540                 


Gly Pro Asn Glu Thr Lys Asn Lys Asp Leu Lys Leu Ser Phe Met Lys 
545                 550                 555                 560 


Lys Leu Asn Leu Thr Leu Ser Pro Ala Lys Lys Gln Pro Val Ser Gln 
                565                 570                 575     


Asp Asn Gln His Lys Ile Thr Asp Ile Pro Lys Ser Ser Gly Val Cys 
            580                 585                 590         


Asp Ser Glu Ser Ser Met Gln Val Lys Thr Val Ala Tyr Val Pro Ser 
        595                 600                 605             


Ile Ser Glu His Ile Leu Gly Glu Ala Ala Val Ser Glu His Thr Met 
    610                 615                 620                 


Gly Glu Thr Lys Ser Thr Leu Leu Glu Pro Lys Val Ala Leu Leu Ala 
625                 630                 635                 640 


Val Thr Glu Pro Arg Ile Gly Ile Ser Glu Thr Asn Lys Glu Asp Glu 
                645                 650                 655     


Asn Ser Leu Leu Val Arg Ser Val Asp Asn Thr Met His Cys Glu Glu 
            660                 665                 670         


Pro Ile Cys Gly Thr Glu Thr Ser Phe Pro Ser Pro Met Glu Ile Gln 
        675                 680                 685             


Gln Thr Glu Ser Leu Phe Pro Ser Thr Gly Met Lys Gln Thr Ile Asn 
    690                 695                 700                 


Asn Gly Arg Ala Ala Ala Pro Val Val Met Asp Val Leu Gln Thr Asp 
705                 710                 715                 720 


Val Ser Gln Asn Phe Gly Leu Glu Leu Asp Thr Lys Arg Asn Asp Asn 
                725                 730                 735     


Ser Asp Tyr Cys Gly Ile Ser Glu Gly Met Glu Met Lys Val Ala Leu 
            740                 745                 750         


Ser Thr Thr Val Ser Glu Thr Thr Glu Ser Ile Leu Gln Pro Ser Ile 
        755                 760                 765             


Glu Glu Ala Asp Ile Leu Pro Ile Met Leu Ser Glu Asp Asn Asn Pro 
    770                 775                 780                 


Lys Phe Glu Pro Ser Val Ile Val Thr Pro Leu Val Glu Ser Lys Ser 
785                 790                 795                 800 


Cys His Leu Glu Pro Cys Leu Pro Lys Glu Thr Leu Asp Ser Ser Leu 
                805                 810                 815     


Gln Gln Thr Glu Leu Met Asp His Arg Met Ala Thr Gly Glu Thr Asn 
            820                 825                 830         


Ser Val Tyr His Asp Asp Asp Asn Ser Val Leu Ser Ile Asp Leu Asn 
        835                 840                 845             


His Leu Arg Pro Ile Pro Glu Ala Ile Ser Pro Leu Asn Ser Pro Val 
    850                 855                 860                 


Arg Pro Val Ala Lys Val Leu Arg Asn Glu Ser Pro Pro Gln Val Pro 
865                 870                 875                 880 


Val Tyr Asn Asn Ser His Lys Asp Val Phe Leu Pro Asn Ser Ala His 
                885                 890                 895     


Ser Thr Ser Lys Ser Gln Ser Asp Leu Asn Lys Glu Asn Gln Lys Pro 
            900                 905                 910         


Ile Tyr Lys Ser Asp Lys Cys Thr Glu Ala Asp Thr Cys Lys Asn Ser 
        915                 920                 925             


Pro Leu Asp Glu Leu Glu Glu Gly Glu Ile Arg Ser Asp Ser Glu Thr 
    930                 935                 940                 


Ser Lys Pro Gln Glu Ser Phe Glu Lys Asn Ser Lys Arg Arg Val Ser 
945                 950                 955                 960 


Ala Asp Val Arg Lys Ser Lys Thr Ile Pro Arg Arg Gly Lys Ser Thr 
                965                 970                 975     


Val Cys Leu Asp Lys Asp Ser Arg Lys Thr His Val Arg Ile His Gln 
            980                 985                 990         


Thr Asn Asn Lys Trp Asn Lys Arg  Pro Asp Lys Ser Ser  Arg Ser Ser 
        995                 1000                 1005             


Lys Thr  Glu Lys Lys Asp Lys  Val Met Ser Thr Ser  Ser Leu Glu 
    1010                 1015                 1020             


Lys Ile  Val Pro Ile Ile Ala  Val Pro Ser Ser Glu  Gln Glu Ile 
    1025                 1030                 1035             


Met His  Met Leu Arg Met Ile  Arg Lys His Val Arg  Lys Asn Tyr 
    1040                 1045                 1050             


Met Lys  Phe Lys Ala Lys Phe  Ser Leu Ile Gln Phe  His Arg Ile 
    1055                 1060                 1065             


Ile Glu  Ser Ala Ile Leu Ser  Phe Thr Ser Leu Ile  Lys His Leu 
    1070                 1075                 1080             


Asn Leu  His Lys Ile Ser Lys  Ser Val Thr Thr Leu  Gln Lys Asn 
    1085                 1090                 1095             


Leu Cys  Asp Ile Ile Glu Ser  Lys Leu Lys Gln Val  Lys Lys Asn 
    1100                 1105                 1110             


Gly Ile  Val Asp Arg Leu Phe  Glu Gln Gln Leu Pro  Asp Met Lys 
    1115                 1120                 1125             


Lys Lys  Leu Trp Lys Phe Val  Asp Asp Gln Leu Asp  Tyr Leu Phe 
    1130                 1135                 1140             


Ala Lys  Leu Lys Lys Ile Leu  Val Cys Asp Ser Lys  Ser Phe Gly 
    1145                 1150                 1155             


Arg Asp  Ser Asp Glu Gly Lys  Leu Glu Lys Thr Ser  Lys Gln Asn 
    1160                 1165                 1170             


Ala Gln  Tyr Ser Asn Ser Gln  Lys Arg Ser Val Asp  Asn Ser Asn 
    1175                 1180                 1185             


Arg Glu  Leu Leu Lys Glu Lys  Leu Ser Lys Ser Glu  Asp Pro Val 
    1190                 1195                 1200             


His Tyr  Lys Ser Leu Val Gly  Cys Lys Lys Ser Glu  Glu Asn Tyr 
    1205                 1210                 1215             


Gln Asp  Gln Asn Asn Ser Ser  Ile Asn Thr Val Lys  His Asp Ile 
    1220                 1225                 1230             


Lys Lys  Asn Phe Asn Ile Cys  Phe Asp Asn Ile Lys  Asn Ser Gln 
    1235                 1240                 1245             


Ser Glu  Glu Arg Ser Leu Glu  Val His Cys Pro Ser  Thr Pro Lys 
    1250                 1255                 1260             


Ser Glu  Lys Asn Glu Gly Ser  Ser Ile Glu Asp Ala  Gln Thr Ser 
    1265                 1270                 1275             


Gln His  Ala Thr Leu Lys Pro  Glu Arg Ser Phe Glu  Ile Leu Thr 
    1280                 1285                 1290             


Glu Gln  Gln Ala Ser Ser Leu  Thr Phe Asn Leu Val  Ser Asp Ala 
    1295                 1300                 1305             


Gln Met  Gly Glu Ile Phe Lys  Ser Leu Leu Gln Gly  Ser Asp Leu 
    1310                 1315                 1320             


Leu Asp  Ser Ser Val Asn Cys  Thr Glu Lys Ser Glu  Trp Glu Leu 
    1325                 1330                 1335             


Lys Thr  Pro Glu Lys Gln Leu  Leu Glu Thr Leu Lys  Cys Glu Ser 
    1340                 1345                 1350             


Ile Pro  Ala Cys Thr Thr Glu  Glu Leu Val Ser Gly  Val Ala Ser 
    1355                 1360                 1365             


Pro Cys  Pro Lys Met Ile Ser  Asp Asp Asn Trp Ser  Leu Leu Ser 
    1370                 1375                 1380             


Ser Glu  Lys Gly Pro Ser Leu  Ser Ser Gly Leu Ser  Leu Pro Val 
    1385                 1390                 1395             


His Pro  Asp Val Leu Asp Glu  Ser Cys Met Phe Glu  Val Ser Thr 
    1400                 1405                 1410             


Asn Leu  Pro Leu Ser Lys Asp  Asn Val Cys Ser Val  Glu Lys Ser 
    1415                 1420                 1425             


Lys Pro  Cys Val Ser Ser Ile  Leu Leu Glu Asp Leu  Ala Val Ser 
    1430                 1435                 1440             


Leu Thr  Val Pro Ser Pro Leu  Lys Ser Asp Gly His  Leu Ser Phe 
    1445                 1450                 1455             


Leu Lys  Pro Asp Met Ser Ser  Ser Ser Thr Pro Glu  Glu Val Ile 
    1460                 1465                 1470             


Ser Ala  His Phe Ser Glu Asp  Ala Leu Leu Glu Glu  Glu Asp Ala 
    1475                 1480                 1485             


Ser Glu  Gln Asp Ile His Leu  Ala Leu Glu Ser Asp  Asn Ser Ser 
    1490                 1495                 1500             


Ser Lys  Ser Ser Cys Ser Ser  Ser Trp Thr Ser Arg  Ser Val Ala 
    1505                 1510                 1515             


Pro Gly  Phe Gln Tyr His Pro  Asn Leu Pro Met His  Ala Val Ile 
    1520                 1525                 1530             


Met Glu  Lys Ser Asn Asp His  Phe Ile Val Lys Ile  Arg Arg Ala 
    1535                 1540                 1545             


Thr Pro  Ser Thr Ser Ser Gly  Leu Lys Gln Ser Met  Met Pro Asp 
    1550                 1555                 1560             


Glu Leu  Leu Thr Ser Leu Pro  Arg His Gly Lys Glu  Ala Asp Glu 
    1565                 1570                 1575             


Gly Pro  Glu Lys Glu Tyr Ile  Ser Cys Gln Asn Thr  Val Phe Lys 
    1580                 1585                 1590             


Ser Val  Glu Glu Leu Glu Asn  Ser Asn Lys Asn Val  Asp Gly Ser 
    1595                 1600                 1605             


Lys Ser  Thr His Glu Glu Gln  Ser Ser Met Ile Gln  Thr Gln Val 
    1610                 1615                 1620             


Pro Asp  Ile Tyr Glu Phe Leu  Lys Asp Ala Ser Asp  Lys Met Gly 
    1625                 1630                 1635             


His Ser  Asp Glu Val Ala Asp  Glu Cys Phe Lys Leu  His Gln Val 
    1640                 1645                 1650             


Trp Glu  Thr Lys Val Pro Glu  Ser Ile Glu Glu Leu  Pro Ser Met 
    1655                 1660                 1665             


Glu Glu  Ile Ser His Ser Val  Gly Glu His Leu Pro  Asn Thr Tyr 
    1670                 1675                 1680             


Val Asp  Leu Thr Lys Asp Pro  Val Thr Glu Thr Lys  Asn Leu Gly 
    1685                 1690                 1695             


Glu Phe  Ile Glu Val Thr Val  Leu His Ile Asp Gln  Leu Gly Cys 
    1700                 1705                 1710             


Ser Gly  Gly Asn Leu Asn Gln  Ser Ala Gln Ile Leu  Asp Asn Ser 
    1715                 1720                 1725             


Leu Gln  Ala Asp Thr Val Gly  Ala Phe Ile Asp Leu  Thr Gln Asp 
    1730                 1735                 1740             


Ala Ser  Ser Glu Ala Lys Ser  Glu Gly Asn His Pro  Ala Leu Ala 
    1745                 1750                 1755             


Val Glu  Asp Leu Gly Cys Gly  Val Ile Gln Val Asp  Glu Asp Asn 
    1760                 1765                 1770             


Cys Lys  Glu Glu Lys Ala Gln  Val Ala Asn Arg Pro  Leu Lys Cys 
    1775                 1780                 1785             


Ile Val  Glu Glu Thr Tyr Ile  Asp Leu Thr Thr Glu  Ser Pro Ser 
    1790                 1795                 1800             


Ser Cys  Glu Val Lys Lys Asp  Glu Leu Lys Ser Glu  Pro Gly Ser 
    1805                 1810                 1815             


Asn Cys  Asp Asn Ser Glu Leu  Pro Gly Thr Leu His  Asn Ser His 
    1820                 1825                 1830             


Lys Lys  Arg Arg Asn Ile Ser  Asp Leu Asn His Pro  His Lys Lys 
    1835                 1840                 1845             


Gln Arg  Lys Glu Thr Asp Leu  Thr Asn Lys Glu Lys  Thr Lys Lys 
    1850                 1855                 1860             


Pro Thr  Gln Asp Ser Cys Glu  Asn Thr Glu Ala His  Gln Lys Lys 
    1865                 1870                 1875             


Ala Ser  Lys Lys Lys Ala Pro  Pro Val Thr Lys Asp  Pro Ser Ser 
    1880                 1885                 1890             


Leu Lys  Ala Thr Pro Gly Ile  Lys Asp Ser Ser Ala  Ala Leu Ala 
    1895                 1900                 1905             


Thr Ser  Thr Ser Leu Ser Ala  Lys Asn Val Ile Lys  Lys Lys Gly 
    1910                 1915                 1920             


Glu Ile  Ile Ile Leu Trp Thr  Arg Asn Asp Asp Arg  Glu Ile Leu 
    1925                 1930                 1935             


Leu Glu  Cys Gln Lys Arg Gly  Pro Ser Phe Lys Thr  Phe Ala Tyr 
    1940                 1945                 1950             


Leu Ala  Ala Lys Leu Asp Lys  Asn Pro Asn Gln Val  Ser Glu Arg 
    1955                 1960                 1965             


Phe Gln  Gln Leu Met Lys Leu  Phe Glu Lys Ser Lys  Cys Arg 
    1970                 1975                 1980         


<210>  1614
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP8__Homo_sapiens__NP_001073594

<400>  1614

Met Glu Gly Gly Arg Arg Ala Arg Val Val Ile Glu Ser Lys Arg Asn 
1               5                   10                  15      


Phe Phe Leu Gly Ala Phe Pro Thr Pro Phe Pro Ala Glu His Val Glu 
            20                  25                  30          


Leu Gly Arg Leu Gly Asp Ser Glu Thr Ala Met Val Pro Gly Lys Gly 
        35                  40                  45              


Gly Ala Asp Tyr Ile Leu Leu Pro Phe Lys Lys Met Asp Phe Ser Arg 
    50                  55                  60                  


Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser Glu Asp Leu Ala Ser 
65                  70                  75                  80  


Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln Arg Lys Gln Glu Pro 
                85                  90                  95      


Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu Gln Glu Lys Arg Met 
            100                 105                 110         


Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu Leu Leu Phe Arg Ile 
        115                 120                 125             


Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn Thr Arg Lys Glu Glu 
    130                 135                 140                 


Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala Gln Ile Ser Ala Tyr 
145                 150                 155                 160 


Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val Ser Arg Ser Glu Leu 
                165                 170                 175     


Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile Ser Lys Cys Lys Leu 
            180                 185                 190         


Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg 
        195                 200                 205             


Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala 
    210                 215                 220                 


Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe 
225                 230                 235                 240 


Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser Pro Asp Glu Phe Ser 
                245                 250                 255     


Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile Ser Asp Ser Pro Arg 
            260                 265                 270         


Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys Val Tyr Gln Met Lys 
        275                 280                 285             


Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala 
    290                 295                 300                 


Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn 
305                 310                 315                 320 


Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr Thr Phe Glu Glu Leu 
                325                 330                 335     


His Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile Tyr 
            340                 345                 350         


Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys 
        355                 360                 365             


Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly 
    370                 375                 380                 


Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe Thr 
385                 390                 395                 400 


Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile 
                405                 410                 415     


Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Thr 
            420                 425                 430         


Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro Gln 
        435                 440                 445             


Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala Thr 
    450                 455                 460                 


Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp Tyr 
465                 470                 475                 480 


Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly Asp 
                485                 490                 495     


Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn Lys 
            500                 505                 510         


Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe Thr 
        515                 520                 525             


Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    530                 535             


<210>  1615
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASP9__Homo_sapiens__XP_011540572

<400>  1615

Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 
1               5                   10                  15      


Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 
            20                  25                  30          


Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 
        35                  40                  45              


Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 
    50                  55                  60                  


Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 
65                  70                  75                  80  


Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 
                85                  90                  95      


Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 
            100                 105                 110         


Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 
        115                 120                 125             


Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 
    130                 135                 140                 


Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 
145                 150                 155                 160 


Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 
                165                 170                 175     


Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 
            180                 185                 190         


Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 
        195                 200                 205             


Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 
    210                 215                 220                 


Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 
225                 230                 235                 240 


Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 
                245                 250                 255     


Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 
            260                 265                 270         


Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 
        275                 280                 285             


Gly Gly Cys Gln Ala Asp Pro Ala Pro Ser His Ser Arg Leu Arg Pro 
    290                 295                 300                 


Pro Cys Cys Ala Val Ser Arg His Ser Gln Thr Pro Gly Ala Asp Ser 
305                 310                 315                 320 


Gly Val Ser Thr Lys Lys Thr Thr Arg Ser Asn Glu Pro Gln Asn Leu 
                325                 330                 335     


Glu Lys Asn Met Ala Val Thr Asp Gln Arg Gly Pro Pro Leu Glu Ala 
            340                 345                 350         


Gly Gly Leu Arg Glu Lys Gln Trp Asp Ser 
        355                 360         


<210>  1616
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASQ1__Homo_sapiens__NP_001222

<400>  1616

Met Ser Ala Thr Asp Arg Met Gly Pro Arg Ala Val Pro Gly Leu Arg 
1               5                   10                  15      


Leu Ala Leu Leu Leu Leu Leu Val Leu Gly Thr Pro Lys Ser Gly Val 
            20                  25                  30          


Gln Gly Gln Glu Gly Leu Asp Phe Pro Glu Tyr Asp Gly Val Asp Arg 
        35                  40                  45              


Val Ile Asn Val Asn Ala Lys Asn Tyr Lys Asn Val Phe Lys Lys Tyr 
    50                  55                  60                  


Glu Val Leu Ala Leu Leu Tyr His Glu Pro Pro Glu Asp Asp Lys Ala 
65                  70                  75                  80  


Ser Gln Arg Gln Phe Glu Met Glu Glu Leu Ile Leu Glu Leu Ala Ala 
                85                  90                  95      


Gln Val Leu Glu Asp Lys Gly Val Gly Phe Gly Leu Val Asp Ser Glu 
            100                 105                 110         


Lys Asp Ala Ala Val Ala Lys Lys Leu Gly Leu Thr Glu Val Asp Ser 
        115                 120                 125             


Met Tyr Val Phe Lys Gly Asp Glu Val Ile Glu Tyr Asp Gly Glu Phe 
    130                 135                 140                 


Ser Ala Asp Thr Ile Val Glu Phe Leu Leu Asp Val Leu Glu Asp Pro 
145                 150                 155                 160 


Val Glu Leu Ile Glu Gly Glu Arg Glu Leu Gln Ala Phe Glu Asn Ile 
                165                 170                 175     


Glu Asp Glu Ile Lys Leu Ile Gly Tyr Phe Lys Ser Lys Asp Ser Glu 
            180                 185                 190         


His Tyr Lys Ala Phe Glu Asp Ala Ala Glu Glu Phe His Pro Tyr Ile 
        195                 200                 205             


Pro Phe Phe Ala Thr Phe Asp Ser Lys Val Ala Lys Lys Leu Thr Leu 
    210                 215                 220                 


Lys Leu Asn Glu Ile Asp Phe Tyr Glu Ala Phe Met Glu Glu Pro Val 
225                 230                 235                 240 


Thr Ile Pro Asp Lys Pro Asn Ser Glu Glu Glu Ile Val Asn Phe Val 
                245                 250                 255     


Glu Glu His Arg Arg Ser Thr Leu Arg Lys Leu Lys Pro Glu Ser Met 
            260                 265                 270         


Tyr Glu Thr Trp Glu Asp Asp Met Asp Gly Ile His Ile Val Ala Phe 
        275                 280                 285             


Ala Glu Glu Ala Asp Pro Asp Gly Phe Glu Phe Leu Glu Thr Leu Lys 
    290                 295                 300                 


Ala Val Ala Gln Asp Asn Thr Glu Asn Pro Asp Leu Ser Ile Ile Trp 
305                 310                 315                 320 


Ile Asp Pro Asp Asp Phe Pro Leu Leu Val Pro Tyr Trp Glu Lys Thr 
                325                 330                 335     


Phe Asp Ile Asp Leu Ser Ala Pro Gln Ile Gly Val Val Asn Val Thr 
            340                 345                 350         


Asp Ala Asp Ser Val Trp Met Glu Met Asp Asp Glu Glu Asp Leu Pro 
        355                 360                 365             


Ser Ala Glu Glu Leu Glu Asp Trp Leu Glu Asp Val Leu Glu Gly Glu 
    370                 375                 380                 


Ile Asn Thr Glu Asp Asp Asp Asp Asp Asp Asp Asp 
385                 390                 395     


<210>  1617
<211>  1088
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASR__Homo_sapiens__NP_001171536

<400>  1617

Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His 
1               5                   10                  15      


Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          


Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              


Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  


Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  


Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg 
                85                  90                  95      


Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         


Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             


Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 


Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 


Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     


Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         


Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             


Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 


Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 


Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                245                 250                 255     


Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             


Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 


Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 


Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                325                 330                 335     


Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         


Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             


Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
    370                 375                 380                 


Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 


Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile 
                405                 410                 415     


Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         


Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             


Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 


Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 


Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     


Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         


Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             


Leu Trp Ser Gly Phe Ser Arg Glu Pro Leu Thr Phe Val Leu Ser Val 
    530                 535                 540                 


Leu Gln Val Pro Phe Ser Asn Cys Ser Arg Asp Cys Leu Ala Gly Thr 
545                 550                 555                 560 


Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr Cys Cys Phe Glu Cys Val 
                565                 570                 575     


Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu Thr Asp Ala Ser Ala Cys 
            580                 585                 590         


Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn Glu Asn His Thr Ser Cys 
        595                 600                 605             


Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp Thr Glu Pro Phe Gly Ile 
    610                 615                 620                 


Ala Leu Thr Leu Phe Ala Val Leu Gly Ile Phe Leu Thr Ala Phe Val 
625                 630                 635                 640 


Leu Gly Val Phe Ile Lys Phe Arg Asn Thr Pro Ile Val Lys Ala Thr 
                645                 650                 655     


Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe Ser Leu Leu Cys Cys Phe 
            660                 665                 670         


Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro Gln Asp Trp Thr Cys Arg 
        675                 680                 685             


Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe Val Leu Cys Ile Ser Cys 
    690                 695                 700                 


Ile Leu Val Lys Thr Asn Arg Val Leu Leu Val Phe Glu Ala Lys Ile 
705                 710                 715                 720 


Pro Thr Ser Phe His Arg Lys Trp Trp Gly Leu Asn Leu Gln Phe Leu 
                725                 730                 735     


Leu Val Phe Leu Cys Thr Phe Met Gln Ile Val Ile Cys Val Ile Trp 
            740                 745                 750         


Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg Asn Gln Glu Leu Glu Asp 
        755                 760                 765             


Glu Ile Ile Phe Ile Thr Cys His Glu Gly Ser Leu Met Ala Leu Gly 
    770                 775                 780                 


Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala Ala Ile Cys Phe Phe Phe 
785                 790                 795                 800 


Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn Phe Asn Glu Ala Lys Phe 
                805                 810                 815     


Ile Thr Phe Ser Met Leu Ile Phe Phe Ile Val Trp Ile Ser Phe Ile 
            820                 825                 830         


Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe Val Ser Ala Val Glu Val 
        835                 840                 845             


Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu Leu Ala Cys Ile Phe Phe 
    850                 855                 860                 


Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro Ser Arg Asn Thr Ile Glu 
865                 870                 875                 880 


Glu Val Arg Cys Ser Thr Ala Ala His Ala Phe Lys Val Ala Ala Arg 
                885                 890                 895     


Ala Thr Leu Arg Arg Ser Asn Val Ser Arg Lys Arg Ser Ser Ser Leu 
            900                 905                 910         


Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser Ser Ile Ser Ser Lys Ser 
        915                 920                 925             


Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu Arg Gln Lys Gln Gln Gln 
    930                 935                 940                 


Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln Gln Gln Pro Leu Thr Leu 
945                 950                 955                 960 


Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro Arg Cys Lys Gln Lys Val 
                965                 970                 975     


Ile Phe Gly Ser Gly Thr Val Thr Phe Ser Leu Ser Phe Asp Glu Pro 
            980                 985                 990         


Gln Lys Asn Ala Met Ala His Arg  Asn Ser Thr His Gln  Asn Ser Leu 
        995                 1000                 1005             


Glu Ala  Gln Lys Ser Ser Asp  Thr Leu Thr Arg His  Gln Pro Leu 
    1010                 1015                 1020             


Leu Pro  Leu Gln Cys Gly Glu  Thr Asp Leu Asp Leu  Thr Val Gln 
    1025                 1030                 1035             


Glu Thr  Gly Leu Gln Gly Pro  Val Gly Gly Asp Gln  Arg Pro Glu 
    1040                 1045                 1050             


Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala Leu Val  Val Ser Ser 
    1055                 1060                 1065             


Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly Ser Thr  Val Thr Glu 
    1070                 1075                 1080             


Asn Val  Val Asn Ser 
    1085             


<210>  1618
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASS4__Homo_sapiens__NP_001157587

<400>  1618

Met Lys Gly Thr Gly Ile Met Asp Cys Ala Pro Lys Ala Leu Leu Ala 
1               5                   10                  15      


Arg Ala Leu Tyr Asp Asn Cys Pro Asp Cys Ser Asp Glu Leu Ala Phe 
            20                  25                  30          


Ser Arg Gly Asp Ile Leu Thr Ile Leu Glu Gln His Val Pro Glu Ser 
        35                  40                  45              


Glu Gly Trp Trp Lys Cys Leu Leu His Gly Arg Gln Gly Leu Ala Pro 
    50                  55                  60                  


Ala Asn Arg Leu Gln Ile Leu Thr Glu Val Ala Ala Asp Arg Pro Cys 
65                  70                  75                  80  


Pro Pro Phe Leu Arg Gly Leu Glu Glu Ala Pro Ala Ser Ser Glu Glu 
                85                  90                  95      


Thr Tyr Gln Val Pro Thr Leu Pro Arg Pro Pro Thr Pro Gly Pro Val 
            100                 105                 110         


Tyr Glu Gln Met Arg Ser Trp Ala Glu Gly Pro Gln Pro Pro Thr Ala 
        115                 120                 125             


Gln Val Tyr Glu Phe Pro Asp Pro Pro Thr Ser Ala Arg Ile Ile Cys 
    130                 135                 140                 


Glu Lys Thr Leu Ser Phe Pro Lys Gln Ala Ile Leu Thr Leu Pro Arg 
145                 150                 155                 160 


Pro Val Arg Ala Ser Leu Pro Thr Leu Pro Ser Gln Val Tyr Asp Val 
                165                 170                 175     


Pro Thr Gln His Arg Gly Pro Val Val Leu Lys Glu Pro Glu Lys Gln 
            180                 185                 190         


Gln Leu Tyr Asp Ile Pro Ala Ser Pro Lys Lys Ala Gly Leu His Pro 
        195                 200                 205             


Pro Asp Ser Gln Ala Ser Asn Pro Gly Pro Leu Ile Pro Gln Pro Ser 
    210                 215                 220                 


Ser Gln Gln Thr Pro Glu Arg Lys Pro Arg Leu Ser Glu His Cys Arg 
225                 230                 235                 240 


Leu Tyr Phe Gly Ala Leu Phe Lys Ala Ile Ser Ala Phe His Gly Ser 
                245                 250                 255     


Leu Ser Ser Ser Gln Pro Ala Glu Ile Ile Thr Gln Ser Lys Leu Val 
            260                 265                 270         


Ile Met Val Gly Gln Lys Leu Val Asp Thr Leu Cys Met Glu Thr Gln 
        275                 280                 285             


Glu Arg Asp Val Arg Asn Glu Ile Leu Arg Gly Ser Ser His Leu Cys 
    290                 295                 300                 


Ser Leu Leu Lys Asp Val Ala Leu Ala Thr Lys Asn Ala Val Leu Thr 
305                 310                 315                 320 


Tyr Pro Ser Pro Ala Ala Leu Gly His Leu Gln Ala Glu Ala Glu Lys 
                325                 330                 335     


Leu Glu Gln His Thr Arg Gln Phe Arg Gly Thr Leu Gly 
            340                 345                 


<210>  1619
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAST__Homo_sapiens__NP_001035905

<400>  1619

Met Ser Gln Pro Gly Gln Lys Pro Ala Ala Ser Pro Arg Pro Arg Arg 
1               5                   10                  15      


Ala Ala Ala Ala Arg Arg Thr His Glu His Val Ser Glu Lys Thr Ser 
            20                  25                  30          


Glu Ser Pro Ser Lys Pro Gly Glu Lys Lys Gly Ser Asp Glu Lys Lys 
        35                  40                  45              


Ala Ala Ser Leu Gly Ser Ser Gln Ser Ser Arg Thr Tyr Ala Gly Gly 
    50                  55                  60                  


Thr Ala Ser Ala Thr Lys Val Ser Ala Ser Ser Gly Ala Thr Ser Lys 
65                  70                  75                  80  


Ser Ser Ser Met Asn Pro Thr Glu Thr Lys Ala Val Lys Thr Glu Pro 
                85                  90                  95      


Glu Lys Lys Ser Gln Ser Thr Lys Pro Lys Ser Leu Pro Lys Gln Ala 
            100                 105                 110         


Ser Asp Thr Gly Ser Asn Asp Ala His Asn Lys Lys Ala Val Ser Arg 
        115                 120                 125             


Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser Thr Glu Pro Lys Thr Lys 
    130                 135                 140                 


Pro Gln Asp Met Ile Ser Ala Gly Gly Glu Ser Val Ala Gly Ile Thr 
145                 150                 155                 160 


Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys Lys Glu Lys Lys Ser Leu 
                165                 170                 175     


Thr Pro Ala Val Pro Val Glu Ser Lys Pro Asp Lys Pro Ser Gly Lys 
            180                 185                 190         


Ser Gly Met Asp Ala Ala Leu Asp Asp Leu Ile Asp Thr Leu Gly Gly 
        195                 200                 205             


Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr Tyr Thr Gly Pro Glu Val 
    210                 215                 220                 


Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu Glu Leu Gly Lys Arg Glu 
225                 230                 235                 240 


Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu Leu Ala Lys Lys Glu Gly 
                245                 250                 255     


Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys Pro Ile Gly Pro Asp Asp 
            260                 265                 270         


Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr Cys Gly Ser Pro Thr Ala 
        275                 280                 285             


Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser Thr Glu Val Leu Lys Ala 
    290                 295                 300                 


Gln Ser Ala Gly Thr Val Arg Ser Ala Ala Pro Pro Gln Glu Lys Lys 
305                 310                 315                 320 


Arg Lys Val Glu Lys Asp Thr Met Ser Asp Gln Ala Leu Glu Ala Leu 
                325                 330                 335     


Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu Pro Glu Leu Asp Leu Arg 
            340                 345                 350         


Ser Ile Lys Glu Val Asp Glu Ala Lys Ala Lys Glu Glu Lys Leu Glu 
        355                 360                 365             


Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro Ser Glu Tyr Arg Leu Lys 
    370                 375                 380                 


Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu Pro Glu Glu 
385                 390                 395                 400 


Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu Ile Asp Glu Leu Ser Glu 
                405                 410                 415     


Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys Pro Ser Lys Pro Thr Glu 
            420                 425                 430         


Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro Ala Pro Val Ser Glu Ala 
        435                 440                 445             


Val Cys Arg Thr Ser Met Cys Ser Ile Gln Ser Ala Pro Pro Glu Pro 
    450                 455                 460                 


Ala Thr Leu Lys Gly Thr Val Pro Asp Asp Ala Val Glu Ala Leu Ala 
465                 470                 475                 480 


Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro Glu Asp Gly Lys Pro Val 
                485                 490                 495     


Met Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp Arg Glu Lys Leu 
            500                 505                 510         


Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu Glu Glu Val 
        515                 520                 525             


Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ser Lys Glu Gln 
    530                 535                 540                 


Leu Pro Pro Met Ser Glu Asp Phe Leu Leu Asp Ala Leu Ser Glu Asp 
545                 550                 555                 560 


Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu Lys Phe Glu Asp Ala Lys 
                565                 570                 575     


Leu Ala Ala Ala Ile Ser Glu Val Val Ser Gln Thr Pro Ala Ser Thr 
            580                 585                 590         


Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr Ser Gln Ser Asp Lys Asp 
        595                 600                 605             


Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp Ser Leu Gly Gln Arg Gln 
    610                 615                 620                 


Pro Asp Pro Asp Glu Asn Lys Pro Met Glu Asp Lys Val Lys Glu Lys 
625                 630                 635                 640 


Ala Lys Ala Glu His Arg Asp Lys Leu Gly Glu Arg Asp Asp Thr Ile 
                645                 650                 655     


Pro Pro Glu Tyr Arg His Leu Leu Asp Asp Asn Gly Gln Asp Lys Pro 
            660                 665                 670         


Val Lys Pro Pro Thr Lys Lys Ser Glu Asp Ser Lys Lys Pro Ala Asp 
        675                 680                 685             


Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly Asp Leu Asp Ser Cys Pro 
    690                 695                 700                 


Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala Lys Asp Lys Cys Lys Lys 
705                 710                 715                 720 


Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn Gly Gly Lys Ala Lys Asp 
                725                 730                 735     


Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys Pro Lys Asp Asp 
            740                 745                 750 


<210>  1620
<211>  1190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CASZ1__Homo_sapiens__XP_011539937

<400>  1620

Met Lys Val Asp Tyr Leu Ser Glu Phe Gly Phe Arg Leu Ser Asp Tyr 
1               5                   10                  15      


Glu Phe Gly Thr Lys Glu Lys Arg Met Asp Leu Gly Thr Ala Glu Gly 
            20                  25                  30          


Thr Arg Cys Thr Asp Pro Pro Ala Gly Lys Pro Ala Met Ala Pro Lys 
        35                  40                  45              


Arg Lys Gly Gly Leu Lys Leu Asn Ala Ile Cys Ala Lys Leu Ser Arg 
    50                  55                  60                  


Gln Val Val Val Glu Lys Arg Ala Asp Ala Gly Ser His Thr Glu Gly 
65                  70                  75                  80  


Ser Pro Ser Gln Pro Arg Asp Gln Glu Arg Ser Gly Pro Glu Ser Gly 
                85                  90                  95      


Ala Ala Arg Ala Pro Arg Ser Glu Glu Asp Lys Arg Arg Ala Val Ile 
            100                 105                 110         


Glu Lys Trp Val Asn Gly Glu Tyr Ser Glu Glu Pro Ala Pro Thr Pro 
        115                 120                 125             


Val Leu Gly Arg Ile Ala Arg Glu Gly Leu Glu Leu Pro Pro Glu Gly 
    130                 135                 140                 


Val Tyr Met Val Gln Pro Gln Gly Cys Ser Asp Glu Glu Asp His Ala 
145                 150                 155                 160 


Glu Glu Pro Ser Lys Asp Gly Gly Ala Leu Glu Glu Lys Asp Ser Asp 
                165                 170                 175     


Gly Ala Ala Ser Lys Glu Asp Ser Gly Pro Ser Thr Arg Gln Ala Ser 
            180                 185                 190         


Gly Glu Ala Ser Ser Leu Arg Asp Tyr Ala Ala Ser Thr Met Thr Glu 
        195                 200                 205             


Phe Leu Gly Met Phe Gly Tyr Asp Asp Gln Asn Thr Arg Asp Glu Leu 
    210                 215                 220                 


Ala Arg Lys Ile Ser Phe Glu Lys Leu His Ala Gly Ser Thr Pro Glu 
225                 230                 235                 240 


Ala Ala Thr Ser Ser Met Leu Pro Thr Ser Glu Asp Thr Leu Ser Lys 
                245                 250                 255     


Arg Ala Arg Phe Ser Lys Tyr Glu Glu Tyr Ile Arg Lys Leu Lys Ala 
            260                 265                 270         


Gly Glu Gln Leu Ser Trp Pro Ala Pro Ser Thr Lys Thr Glu Glu Arg 
        275                 280                 285             


Val Gly Lys Glu Val Val Gly Thr Leu Pro Gly Leu Arg Leu Pro Ser 
    290                 295                 300                 


Ser Thr Ala His Leu Glu Thr Lys Ala Thr Ile Leu Pro Leu Pro Ser 
305                 310                 315                 320 


His Ser Ser Val Gln Met Gln Asn Leu Val Ala Arg Ala Ser Lys Tyr 
                325                 330                 335     


Asp Phe Phe Ile Gln Lys Leu Lys Thr Gly Glu Asn Leu Arg Pro Gln 
            340                 345                 350         


Asn Gly Ser Thr Tyr Lys Lys Pro Ser Lys Tyr Asp Leu Glu Asn Val 
        355                 360                 365             


Lys Tyr Leu His Leu Phe Lys Pro Gly Glu Gly Ser Pro Asp Met Gly 
    370                 375                 380                 


Gly Ala Ile Ala Phe Lys Thr Gly Lys Val Gly Arg Pro Ser Lys Tyr 
385                 390                 395                 400 


Asp Val Arg Gly Ile Gln Lys Pro Gly Pro Ala Lys Val Pro Pro Thr 
                405                 410                 415     


Pro Ser Leu Ala Pro Ala Pro Leu Ala Ser Val Pro Ser Ala Pro Ser 
            420                 425                 430         


Ala Pro Gly Pro Gly Pro Glu Pro Pro Ala Ser Leu Ser Phe Asn Thr 
        435                 440                 445             


Pro Glu Tyr Leu Lys Ser Thr Phe Ser Lys Thr Asp Ser Ile Thr Thr 
    450                 455                 460                 


Gly Thr Val Ser Thr Val Lys Asn Gly Leu Pro Thr Asp Lys Pro Ala 
465                 470                 475                 480 


Val Thr Glu Asp Val Asn Ile Tyr Gln Lys Tyr Ile Ala Arg Phe Ser 
                485                 490                 495     


Gly Ser Gln His Cys Gly His Ile His Cys Ala Tyr Gln Tyr Arg Glu 
            500                 505                 510         


His Tyr His Cys Leu Asp Pro Glu Cys Asn Tyr Gln Arg Phe Thr Ser 
        515                 520                 525             


Lys Gln Asp Val Ile Arg His Tyr Asn Met His Lys Lys Arg Asp Asn 
    530                 535                 540                 


Ser Leu Gln His Gly Phe Met Arg Phe Ser Pro Leu Asp Asp Cys Ser 
545                 550                 555                 560 


Val Tyr Tyr His Gly Cys His Leu Asn Gly Lys Ser Thr His Tyr His 
                565                 570                 575     


Cys Met Gln Val Gly Cys Asn Lys Val Tyr Thr Ser Thr Ser Asp Val 
            580                 585                 590         


Met Thr His Glu Asn Phe His Lys Lys Asn Thr Gln Leu Ile Asn Asp 
        595                 600                 605             


Gly Phe Gln Arg Phe Arg Ala Thr Glu Asp Cys Gly Thr Ala Asp Cys 
    610                 615                 620                 


Gln Phe Tyr Gly Gln Lys Thr Thr His Phe His Cys Arg Arg Pro Gly 
625                 630                 635                 640 


Cys Thr Phe Thr Phe Lys Asn Lys Cys Asp Ile Glu Lys His Lys Ser 
                645                 650                 655     


Tyr His Ile Lys Asp Asp Ala Tyr Ala Lys Asp Gly Phe Lys Lys Phe 
            660                 665                 670         


Tyr Lys Tyr Glu Glu Cys Lys Tyr Glu Gly Cys Val Tyr Ser Lys Ala 
        675                 680                 685             


Thr Asn His Phe His Cys Ile Arg Ala Gly Cys Gly Phe Thr Phe Thr 
    690                 695                 700                 


Ser Thr Ser Gln Met Thr Ser His Lys Arg Lys His Glu Arg Arg His 
705                 710                 715                 720 


Ile Arg Ser Ser Gly Ala Leu Gly Leu Pro Pro Ser Leu Leu Gly Ala 
                725                 730                 735     


Lys Asp Thr Glu His Glu Glu Ser Ser Asn Asp Asp Leu Val Asp Phe 
            740                 745                 750         


Ser Ala Leu Ser Ser Lys Asn Ser Ser Leu Ser Ala Ser Pro Thr Ser 
        755                 760                 765             


Gln Gln Ser Ser Ala Ser Leu Ala Ala Ala Thr Ala Ala Thr Glu Ala 
    770                 775                 780                 


Gly Pro Ser Ala Thr Lys Pro Pro Asn Ser Lys Ile Ser Gly Leu Leu 
785                 790                 795                 800 


Pro Gln Gly Leu Pro Gly Ser Ile Pro Leu Ala Leu Ala Leu Ser Asn 
                805                 810                 815     


Ser Gly Leu Pro Thr Pro Thr Pro Tyr Phe Pro Ile Leu Ala Gly Arg 
            820                 825                 830         


Gly Ser Thr Ser Leu Pro Val Gly Thr Pro Ser Leu Leu Gly Ala Val 
        835                 840                 845             


Ser Ser Gly Ser Ala Ala Ser Ala Thr Pro Asp Thr Pro Thr Leu Val 
    850                 855                 860                 


Ala Ser Gly Ala Gly Asp Ser Ala Pro Val Ala Ala Ala Ser Val Pro 
865                 870                 875                 880 


Ala Pro Pro Ala Ser Ile Met Glu Arg Ile Ser Ala Ser Lys Gly Leu 
                885                 890                 895     


Ile Ser Pro Met Met Ala Arg Leu Ala Ala Ala Ala Leu Lys Pro Ser 
            900                 905                 910         


Ala Thr Phe Asp Pro Gly Ser Gly Gln Gln Val Thr Pro Ala Arg Phe 
        915                 920                 925             


Pro Pro Ala Gln Val Lys Pro Glu Pro Gly Glu Ser Thr Gly Ala Pro 
    930                 935                 940                 


Gly Pro His Glu Ala Ser Gln Asp Arg Ser Leu Asp Leu Thr Val Lys 
945                 950                 955                 960 


Glu Pro Ser Asn Glu Ser Asn Gly His Ala Val Pro Ala Asn Ser Ser 
                965                 970                 975     


Leu Leu Ser Ser Leu Met Asn Lys Met Ser Gln Gly Asn Pro Gly Leu 
            980                 985                 990         


Gly Ser Leu Leu Asn Ile Lys Ala  Glu Ala Glu Gly Ser  Pro Ala Ala 
        995                 1000                 1005             


Glu Pro  Ser Pro Phe Leu Gly  Lys Ala Val Lys Ala  Leu Val Gln 
    1010                 1015                 1020             


Glu Lys  Leu Ala Glu Pro Trp  Lys Val Tyr Leu Arg  Arg Phe Gly 
    1025                 1030                 1035             


Thr Lys  Asp Phe Cys Asp Gly  Gln Cys Asp Phe Leu  His Lys Ala 
    1040                 1045                 1050             


His Phe  His Cys Val Val Glu  Glu Cys Gly Ala Leu  Phe Ser Thr 
    1055                 1060                 1065             


Leu Asp  Gly Ala Ile Lys His  Ala Asn Phe His Phe  Arg Thr Glu 
    1070                 1075                 1080             


Gly Gly  Ala Ala Lys Gly Asn  Thr Glu Ala Ala Phe  Pro Ala Ser 
    1085                 1090                 1095             


Ala Ala  Glu Thr Lys Pro Pro  Met Ala Pro Ser Ser  Pro Pro Val 
    1100                 1105                 1110             


Pro Pro  Val Thr Thr Ala Thr  Val Ser Ser Leu Glu  Gly Pro Ala 
    1115                 1120                 1125             


Pro Ser  Pro Ala Ser Val Pro  Ser Thr Pro Thr Leu  Leu Ala Trp 
    1130                 1135                 1140             


Lys Gln  Leu Ala Ser Thr Ile  Pro Gln Met Pro Gln  Ile Pro Ala 
    1145                 1150                 1155             


Ser Val  Pro His Leu Pro Ala  Ser Pro Leu Ala Thr  Thr Ser Leu 
    1160                 1165                 1170             


Glu Asn  Ala Lys Pro Gln Val  Lys Pro Gly Phe Leu  Gln Phe Gln 
    1175                 1180                 1185             


Glu Lys  
    1190 


<210>  1621
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAT__Homo_sapiens__NP_001743

<400>  1621

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210>  1622
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CATSPER1__Homo_sapiens__NP_444282

<400>  1622

Met Asp Gln Asn Ser Val Pro Glu Lys Ala Gln Asn Glu Ala Asp Thr 
1               5                   10                  15      


Asn Asn Ala Asp Arg Phe Phe Arg Ser His Ser Ser Pro Pro His His 
            20                  25                  30          


Arg Pro Gly His Ser Arg Ala Leu His His Tyr Glu Leu His His His 
        35                  40                  45              


Gly Val Pro His Gln Arg Gly Glu Ser His His Pro Pro Glu Phe Gln 
    50                  55                  60                  


Asp Phe His Asp Gln Ala Leu Ser Ser His Val His Gln Ser His His 
65                  70                  75                  80  


His Ser Glu Ala Arg Asn His Gly Arg Ala His Gly Pro Thr Gly Phe 
                85                  90                  95      


Gly Leu Ala Pro Ser Gln Gly Ala Val Pro Ser His Arg Ser Tyr Gly 
            100                 105                 110         


Glu Asp Tyr His Asp Glu Leu Gln Arg Asp Gly Arg Arg His His Asp 
        115                 120                 125             


Gly Ser Gln Tyr Gly Gly Phe His Gln Gln Ser Asp Ser His Tyr His 
    130                 135                 140                 


Arg Gly Ser His His Gly Arg Pro Gln Tyr Leu Gly Glu Asn Leu Ser 
145                 150                 155                 160 


His Tyr Ser Ser Gly Val Pro His His Gly Glu Ala Ser His His Gly 
                165                 170                 175     


Gly Ser Tyr Leu Pro His Gly Pro Asn Pro Tyr Ser Glu Ser Phe His 
            180                 185                 190         


His Ser Glu Ala Ser His Leu Ser Gly Leu Gln His Asp Glu Ser Gln 
        195                 200                 205             


His His Gln Val Pro His Arg Gly Trp Pro His His His Gln Val His 
    210                 215                 220                 


His His Gly Arg Ser Arg His His Glu Ala His Gln His Gly Lys Ser 
225                 230                 235                 240 


Pro His His Gly Glu Thr Ile Ser Pro His Ser Ser Val Gly Ser Tyr 
                245                 250                 255     


Gln Arg Gly Ile Ser Asp Tyr His Ser Glu Tyr His Gln Gly Asp His 
            260                 265                 270         


His Pro Ser Glu Tyr His His Gly Asp His Pro His His Thr Gln His 
        275                 280                 285             


His Tyr His Gln Thr His Arg His Arg Asp Tyr His Gln His Gln Asp 
    290                 295                 300                 


His His Gly Ala Tyr His Ser Ser Tyr Leu His Gly Asp Tyr Val Gln 
305                 310                 315                 320 


Ser Thr Ser Gln Leu Ser Ile Pro His Thr Ser Arg Ser Leu Ile His 
                325                 330                 335     


Asp Ala Pro Gly Pro Ala Ala Ser Arg Thr Gly Val Phe Pro Tyr His 
            340                 345                 350         


Val Ala His Pro Arg Gly Ser Ala His Ser Met Thr Arg Ser Ser Ser 
        355                 360                 365             


Thr Ile Arg Ser Arg Val Thr Gln Met Ser Lys Lys Val His Thr Gln 
    370                 375                 380                 


Asp Ile Ser Thr Lys His Ser Glu Asp Trp Gly Lys Glu Glu Gly Gln 
385                 390                 395                 400 


Phe Gln Lys Arg Lys Thr Gly Arg Leu Gln Arg Thr Arg Lys Lys Gly 
                405                 410                 415     


His Ser Thr Asn Leu Phe Gln Trp Leu Trp Glu Lys Leu Thr Phe Leu 
            420                 425                 430         


Ile Gln Gly Phe Arg Glu Met Ile Arg Asn Leu Thr Gln Ser Leu Ala 
        435                 440                 445             


Phe Glu Thr Phe Ile Phe Phe Val Val Cys Leu Asn Thr Val Met Leu 
    450                 455                 460                 


Val Ala Gln Thr Phe Ala Glu Val Glu Ile Arg Gly Glu Trp Tyr Phe 
465                 470                 475                 480 


Met Ala Leu Asp Ser Ile Phe Phe Cys Ile Tyr Val Val Glu Ala Leu 
                485                 490                 495     


Leu Lys Ile Ile Ala Leu Gly Leu Ser Tyr Phe Phe Asp Phe Trp Asn 
            500                 505                 510         


Asn Leu Asp Phe Phe Ile Met Ala Met Ala Val Leu Asp Phe Leu Leu 
        515                 520                 525             


Met Gln Thr His Ser Phe Ala Ile Tyr His Gln Ser Leu Phe Arg Ile 
    530                 535                 540                 


Leu Lys Val Phe Lys Ser Leu Arg Ala Leu Arg Ala Ile Arg Val Leu 
545                 550                 555                 560 


Arg Arg Leu Ser Phe Leu Thr Ser Val Gln Glu Val Thr Gly Thr Leu 
                565                 570                 575     


Gly Gln Ser Leu Pro Ser Ile Ala Ala Ile Leu Ile Leu Met Phe Thr 
            580                 585                 590         


Cys Leu Phe Leu Phe Ser Ala Val Leu Arg Ala Leu Phe Arg Lys Ser 
        595                 600                 605             


Asp Pro Lys Arg Phe Gln Asn Ile Phe Thr Thr Ile Phe Thr Leu Phe 
    610                 615                 620                 


Thr Leu Leu Thr Leu Asp Asp Trp Ser Leu Ile Tyr Met Asp Ser Arg 
625                 630                 635                 640 


Ala Gln Gly Ala Trp Tyr Ile Ile Pro Ile Leu Val Ile Tyr Ile Ile 
                645                 650                 655     


Ile Gln Tyr Phe Ile Phe Leu Asn Leu Val Ile Thr Val Leu Val Asp 
            660                 665                 670         


Ser Phe Gln Thr Ala Leu Phe Lys Gly Leu Glu Lys Ala Lys Gln Glu 
        675                 680                 685             


Arg Ala Ala Arg Ile Gln Glu Lys Leu Leu Glu Asp Ser Leu Thr Glu 
    690                 695                 700                 


Leu Arg Ala Ala Glu Pro Lys Glu Val Ala Ser Glu Gly Thr Met Leu 
705                 710                 715                 720 


Lys Arg Leu Ile Glu Lys Lys Phe Gly Thr Met Thr Glu Lys Gln Gln 
                725                 730                 735     


Glu Leu Leu Phe His Tyr Leu Gln Leu Val Ala Ser Val Glu Gln Glu 
            740                 745                 750         


Gln Gln Lys Phe Arg Ser Gln Ala Ala Val Ile Asp Glu Ile Val Asp 
        755                 760                 765             


Thr Thr Phe Glu Ala Gly Glu Glu Asp Phe Arg Asn 
    770                 775                 780 


<210>  1623
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CATSPER2__Homo_sapiens__NP_001269238

<400>  1623

Met Ala Ala Tyr Gln Gln Glu Glu Gln Met Gln Leu Pro Arg Ala Asp 
1               5                   10                  15      


Ala Ile Arg Ser Arg Leu Ile Asp Thr Phe Ser Leu Ile Glu His Leu 
            20                  25                  30          


Gln Gly Leu Ser Gln Ala Val Pro Arg His Thr Ile Arg Glu Leu Leu 
        35                  40                  45              


Asp Pro Ser Arg Gln Lys Lys Leu Val Leu Gly Asp Gln His Gln Leu 
    50                  55                  60                  


Val Arg Phe Ser Ile Lys Pro Gln Arg Ile Glu Gln Ile Ser His Ala 
65                  70                  75                  80  


Gln Arg Leu Leu Ser Arg Leu His Val Arg Cys Ser Gln Arg Pro Pro 
                85                  90                  95      


Leu Ser Leu Trp Ala Gly Trp Val Leu Glu Cys Pro Leu Phe Lys Asn 
            100                 105                 110         


Phe Ile Ile Phe Leu Val Phe Leu Asn Thr Ile Ile Leu Met Val Glu 
        115                 120                 125             


Ile Glu Leu Leu Glu Ser Thr Asn Thr Lys Leu Trp Pro Leu Lys Leu 
    130                 135                 140                 


Thr Leu Glu Val Ala Ala Trp Phe Ile Leu Leu Ile Phe Ile Leu Glu 
145                 150                 155                 160 


Ile Leu Leu Lys Trp Leu Ser Asn Phe Ser Val Phe Trp Lys Ser Ala 
                165                 170                 175     


Trp Asn Val Phe Asp Phe Val Val Thr Met Leu Ser Leu Leu Pro Glu 
            180                 185                 190         


Val Val Val Leu Val Gly Val Thr Gly Gln Ser Val Trp Leu Gln Leu 
        195                 200                 205             


Leu Arg Ile Cys Arg Val Leu Arg Ser Leu Lys Leu Leu Ala Gln Phe 
    210                 215                 220                 


Arg Gln Ile Gln Ile Ile Ile Leu Val Leu Val Arg Ala Leu Lys Ser 
225                 230                 235                 240 


Met Thr Phe Leu Leu Met Leu Leu Leu Ile Phe Phe Tyr Ile Phe Ala 
                245                 250                 255     


Val Thr Gly Val Tyr Val Phe Ser Glu Tyr Thr Arg Ser Pro Arg Gln 
            260                 265                 270         


Asp Leu Glu Tyr His Val Phe Phe Ser Asp Leu Pro Asn Ser Leu Val 
        275                 280                 285             


Thr Val Phe Ile Leu Phe Thr Leu Asp His Trp Tyr Ala Leu Leu Gln 
    290                 295                 300                 


Asp Val Trp Lys Val Pro Glu Val Ser Arg Ile Phe Ser Ser Ile Tyr 
305                 310                 315                 320 


Phe Ile Leu Trp Leu Leu Leu Gly Ser Ile Ile Phe Arg Ser Ile Ile 
                325                 330                 335     


Val Ala Met Met Val Thr Asn Phe Gln Asn Ile Arg Lys Glu Leu Asn 
            340                 345                 350         


Glu Glu Met Ala Arg Arg Glu Val Gln Leu Lys Ala Asp Met Phe Lys 
        355                 360                 365             


Arg Gln Ile Ile Gln Arg Arg Lys Asn Met Ser His Glu Ala Leu Thr 
    370                 375                 380                 


Ser Ser His Ser Lys Ile Glu Asp Arg Gly Ala Ser Gln Gln Arg Glu 
385                 390                 395                 400 


Ser Leu Asp Leu Ser Glu Val Ser Glu Val Glu Ser Asn Tyr Gly Ala 
                405                 410                 415     


Thr Glu Glu Asp Leu Ile Thr Ser Ala Ser Lys Thr Glu Glu Thr Leu 
            420                 425                 430         


Ser Lys Lys Arg Glu Tyr Gln Ser Ser Ser Cys Val Ser Ser Thr Ser 
        435                 440                 445             


Ser Ser Tyr Ser Ser Ser Ser Glu Ser Arg Phe Ser Glu Ser Ile Gly 
    450                 455                 460                 


Arg Leu Asp Trp Glu Thr Leu Val His Glu Asn Leu Pro Gly Leu Met 
465                 470                 475                 480 


Glu Met Asp Gln Asp Asp Arg Val Trp Pro Arg Asp Ser Leu Phe Arg 
                485                 490                 495     


Tyr Phe Glu Leu Leu Glu Lys Leu Gln Tyr Asn Leu Glu Glu Arg Lys 
            500                 505                 510         


Lys Leu Gln Glu Phe Ala Val Gln Ala Leu Met Asn Leu Glu Asp Lys 
        515                 520                 525             


<210>  1624
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAV1__Homo_sapiens__NP_001166366

<400>  1624

Met Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys 
1               5                   10                  15      


Glu Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val 
            20                  25                  30          


Val Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His 
        35                  40                  45              


Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr 
    50                  55                  60                  


Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met 
65                  70                  75                  80  


Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile 
                85                  90                  95      


Trp Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys 
            100                 105                 110         


Ile Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu 
        115                 120                 125             


Phe Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln 
    130                 135                 140                 


Lys Glu Ile 
145         


<210>  1625
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAV2__Homo_sapiens__NP_001224

<400>  1625

Met Gly Leu Glu Thr Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Thr Thr His 
    50                  55                  60                  


Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 
65                  70                  75                  80  


Lys Tyr Val Met Tyr Lys Phe Leu Thr Val Phe Leu Ala Ile Pro Leu 
                85                  90                  95      


Ala Phe Ile Ala Gly Ile Leu Phe Ala Thr Leu Ser Cys Leu His Ile 
            100                 105                 110         


Trp Ile Leu Met Pro Phe Val Lys Thr Cys Leu Met Val Leu Pro Ser 
        115                 120                 125             


Val Gln Thr Ile Trp Lys Ser Val Thr Asp Val Ile Ile Ala Pro Leu 
    130                 135                 140                 


Cys Thr Ser Val Gly Arg Cys Phe Ser Ser Val Ser Leu Gln Leu Ser 
145                 150                 155                 160 


Gln Asp 
        


<210>  1626
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAV3__Homo_sapiens__NP_001225

<400>  1626

Met Met Ala Glu Glu His Thr Asp Leu Glu Ala Gln Ile Val Lys Asp 
1               5                   10                  15      


Ile His Cys Lys Glu Ile Asp Leu Val Asn Arg Asp Pro Lys Asn Ile 
            20                  25                  30          


Asn Glu Asp Ile Val Lys Val Asp Phe Glu Asp Val Ile Ala Glu Pro 
        35                  40                  45              


Val Gly Thr Tyr Ser Phe Asp Gly Val Trp Lys Val Ser Tyr Thr Thr 
    50                  55                  60                  


Phe Thr Val Ser Lys Tyr Trp Cys Tyr Arg Leu Leu Ser Thr Leu Leu 
65                  70                  75                  80  


Gly Val Pro Leu Ala Leu Leu Trp Gly Phe Leu Phe Ala Cys Ile Ser 
                85                  90                  95      


Phe Cys His Ile Trp Ala Val Val Pro Cys Ile Lys Ser Tyr Leu Ile 
            100                 105                 110         


Glu Ile Gln Cys Ile Ser His Ile Tyr Ser Leu Cys Ile Arg Thr Phe 
        115                 120                 125             


Cys Asn Pro Leu Phe Ala Ala Leu Gly Gln Val Cys Ser Ser Ile Lys 
    130                 135                 140                 


Val Val Leu Arg Lys Glu Val 
145                 150     


<210>  1627
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBFA2T2__Homo_sapiens__NP_001028171

<400>  1627

Met Val Gly Val Pro Gly Ala Ala Ala Phe Gln Leu Gly Pro Glu Lys 
1               5                   10                  15      


Arg Val Pro Ala Met Pro Gly Ser Pro Val Glu Val Lys Ile Gln Ser 
            20                  25                  30          


Arg Ser Ser Pro Pro Thr Met Pro Pro Leu Pro Pro Ile Asn Pro Gly 
        35                  40                  45              


Gly Pro Arg Pro Val Ser Phe Thr Pro Thr Ala Leu Ser Asn Gly Ile 
    50                  55                  60                  


Asn His Ser Pro Pro Thr Leu Asn Gly Ala Pro Ser Pro Pro Gln Arg 
65                  70                  75                  80  


Phe Ser Asn Gly Pro Ala Ser Ser Thr Ser Ser Ala Leu Thr Asn Gln 
                85                  90                  95      


Gln Leu Pro Ala Thr Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg 
            100                 105                 110         


Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile 
        115                 120                 125             


Gly Glu Lys Val Arg Thr Leu Val Leu Ala Leu Val Asn Ser Thr Val 
    130                 135                 140                 


Thr Ile Glu Glu Phe His Cys Lys Leu Gln Glu Ala Thr Asn Phe Pro 
145                 150                 155                 160 


Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu 
                165                 170                 175     


Gln Arg Glu Leu Leu His Cys Ala Arg Ala Ala Lys Gln Thr Pro Ser 
            180                 185                 190         


Gln Tyr Leu Ala Gln His Glu His Leu Leu Leu Asn Thr Ser Ile Ala 
        195                 200                 205             


Ser Pro Ala Asp Ser Ser Glu Leu Leu Met Glu Val His Gly Asn Gly 
    210                 215                 220                 


Lys Arg Pro Ser Pro Glu Arg Arg Glu Glu Asn Ser Phe Asp Arg Asp 
225                 230                 235                 240 


Thr Ile Ala Pro Glu Pro Pro Ala Lys Arg Val Cys Thr Ile Ser Pro 
                245                 250                 255     


Ala Pro Arg His Ser Pro Ala Leu Thr Val Pro Leu Met Asn Pro Gly 
            260                 265                 270         


Gly Gln Phe His Pro Thr Pro Pro Pro Leu Gln His Tyr Thr Leu Glu 
        275                 280                 285             


Asp Ile Ala Thr Ser His Leu Tyr Arg Glu Pro Asn Lys Met Leu Glu 
    290                 295                 300                 


His Arg Glu Val Arg Asp Arg His His Ser Leu Gly Leu Asn Gly Gly 
305                 310                 315                 320 


Tyr Gln Asp Glu Leu Val Asp His Arg Leu Thr Glu Arg Glu Trp Ala 
                325                 330                 335     


Asp Glu Trp Lys His Leu Asp His Ala Leu Asn Cys Ile Met Glu Met 
            340                 345                 350         


Val Glu Lys Thr Arg Arg Ser Met Ala Val Leu Arg Arg Cys Gln Glu 
        355                 360                 365             


Ser Asp Arg Glu Glu Leu Asn Tyr Trp Lys Arg Arg Tyr Asn Glu Asn 
    370                 375                 380                 


Thr Glu Leu Arg Lys Thr Gly Thr Glu Leu Val Ser Arg Gln His Ser 
385                 390                 395                 400 


Pro Gly Ser Ala Asp Ser Leu Ser Asn Asp Ser Gln Arg Glu Phe Asn 
                405                 410                 415     


Ser Arg Pro Gly Thr Gly Tyr Val Pro Val Glu Phe Trp Lys Lys Thr 
            420                 425                 430         


Glu Glu Ala Val Asn Lys Val Lys Ile Gln Ala Met Ser Glu Val Gln 
        435                 440                 445             


Lys Ala Val Ala Glu Ala Glu Gln Lys Ala Phe Glu Val Ile Ala Thr 
    450                 455                 460                 


Glu Arg Ala Arg Met Glu Gln Thr Ile Ala Asp Val Lys Arg Gln Ala 
465                 470                 475                 480 


Ala Glu Asp Ala Phe Leu Val Ile Asn Glu Gln Glu Glu Ser Thr Glu 
                485                 490                 495     


Asn Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys 
            500                 505                 510         


Asn Ile Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp Glu 
        515                 520                 525             


Arg His His Arg Leu Cys Gly Gln Asn Leu His Gly Gln Ser Pro His 
    530                 535                 540                 


Gly Gln Gly Arg Pro Leu Leu Pro Val Gly Arg Gly Ser Ser Ala Arg 
545                 550                 555                 560 


Ser Ala Asp Cys Ser Val Pro Ser Pro Ala Leu Asp Lys Thr Ser Ala 
                565                 570                 575     


Thr Thr Ser Arg Ser Ser Thr Pro Ala Ser Val Thr Ala Ile Asp Thr 
            580                 585                 590         


Asn Gly Leu 
        595 


<210>  1628
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBFA2T3__Homo_sapiens__NP_005178

<400>  1628

Met Pro Ala Ser Arg Leu Arg Asp Arg Ala Ala Ser Ser Ala Ser Gly 
1               5                   10                  15      


Ser Thr Cys Gly Ser Met Ser Gln Thr His Pro Val Leu Glu Ser Gly 
            20                  25                  30          


Leu Leu Ala Ser Ala Gly Cys Ser Ala Pro Arg Gly Pro Arg Lys Gly 
        35                  40                  45              


Gly Pro Ala Pro Val Asp Arg Lys Ala Lys Ala Ser Ala Met Pro Asp 
    50                  55                  60                  


Ser Pro Ala Glu Val Lys Thr Gln Pro Arg Ser Thr Pro Pro Ser Met 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Thr Arg Pro Pro Ser 
                85                  90                  95      


Phe Thr Pro His Thr His Arg Glu Asp Gly Pro Ala Thr Leu Pro His 
            100                 105                 110         


Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met Val Cys Leu Leu Met 
        115                 120                 125             


Asn Gly Ser Ser His Ser Pro Thr Ala Ile Asn Gly Ala Pro Cys Thr 
    130                 135                 140                 


Pro Asn Gly Phe Ser Asn Gly Pro Ala Thr Ser Ser Thr Ala Ser Leu 
145                 150                 155                 160 


Ser Thr Gln His Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys 
                165                 170                 175     


Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Ser Asp Ile Ser 
            180                 185                 190         


Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn 
        195                 200                 205             


Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr 
    210                 215                 220                 


Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu 
225                 230                 235                 240 


Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln 
                245                 250                 255     


Thr Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala 
            260                 265                 270         


Ser Ala Ser Ser Pro Ile Asp Ser Ser Glu Leu Leu Leu Glu Val Asn 
        275                 280                 285             


Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly Ser 
    290                 295                 300                 


Asp Arg Asp Pro Leu His Pro Glu His Leu Ser Lys Arg Pro Cys Thr 
305                 310                 315                 320 


Leu Asn Pro Ala Gln Arg Tyr Ser Pro Ser Asn Gly Pro Pro Gln Pro 
                325                 330                 335     


Thr Pro Pro Pro His Tyr Arg Leu Glu Asp Ile Ala Met Ala His His 
            340                 345                 350         


Phe Arg Asp Ala Tyr Arg His Pro Asp Pro Arg Glu Leu Arg Glu Arg 
        355                 360                 365             


His Arg Pro Leu Val Val Pro Gly Ser Arg Gln Glu Glu Val Ile Asp 
    370                 375                 380                 


His Lys Leu Thr Glu Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asn 
385                 390                 395                 400 


Asn Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys Thr Arg Arg Ser 
                405                 410                 415     


Leu Thr Val Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn 
            420                 425                 430         


His Trp Ala Arg Arg Tyr Ser Asp Ala Glu Asp Thr Lys Lys Gly Pro 
        435                 440                 445             


Ala Pro Ala Ala Ala Arg Pro Arg Ser Ser Ser Ala Gly Pro Glu Gly 
    450                 455                 460                 


Pro Gln Leu Asp Val Pro Arg Glu Phe Leu Pro Arg Thr Leu Thr Gly 
465                 470                 475                 480 


Tyr Val Pro Glu Asp Ile Trp Arg Lys Ala Glu Glu Ala Val Asn Glu 
                485                 490                 495     


Val Lys Arg Gln Ala Met Ser Glu Leu Gln Lys Ala Val Ser Asp Ala 
            500                 505                 510         


Glu Arg Lys Ala His Glu Leu Ile Thr Thr Glu Arg Ala Lys Met Glu 
        515                 520                 525             


Arg Ala Leu Ala Glu Ala Lys Arg Gln Ala Ser Glu Asp Ala Leu Thr 
    530                 535                 540                 


Val Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly 
545                 550                 555                 560 


Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Ala Ala Arg Tyr Cys 
                565                 570                 575     


Gly Ser Phe Cys Gln His Arg Asp Trp Glu Lys His His His Val Cys 
            580                 585                 590         


Gly Gln Ser Leu Gln Gly Pro Thr Ala Val Val Ala Asp Pro Val Pro 
        595                 600                 605             


Gly Pro Pro Glu Ala Ala His Ser Leu Gly Pro Ser Leu Pro Val Gly 
    610                 615                 620                 


Ala Ala Ser Pro Ser Glu Ala Gly Ser Ala Gly Pro Ser Arg Pro Gly 
625                 630                 635                 640 


Ser Pro Ser Pro Pro Gly Pro Leu Asp Thr Val Pro Arg 
                645                 650             


<210>  1629
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBFB__Homo_sapiens__NP_001746

<400>  1629

Met Pro Arg Val Val Pro Asp Gln Arg Ser Lys Phe Glu Asn Glu Glu 
1               5                   10                  15      


Phe Phe Arg Lys Leu Ser Arg Glu Cys Glu Ile Lys Tyr Thr Gly Phe 
            20                  25                  30          


Arg Asp Arg Pro His Glu Glu Arg Gln Ala Arg Phe Gln Asn Ala Cys 
        35                  40                  45              


Arg Asp Gly Arg Ser Glu Ile Ala Phe Val Ala Thr Gly Thr Asn Leu 
    50                  55                  60                  


Ser Leu Gln Phe Phe Pro Ala Ser Trp Gln Gly Glu Gln Arg Gln Thr 
65                  70                  75                  80  


Pro Ser Arg Glu Tyr Val Asp Leu Glu Arg Glu Ala Gly Lys Val Tyr 
                85                  90                  95      


Leu Lys Ala Pro Met Ile Leu Asn Gly Val Cys Val Ile Trp Lys Gly 
            100                 105                 110         


Trp Ile Asp Leu Gln Arg Leu Asp Gly Met Gly Cys Leu Glu Phe Asp 
        115                 120                 125             


Glu Glu Arg Ala Gln Gln Glu Asp Ala Leu Ala Gln Gln Ala Phe Glu 
    130                 135                 140                 


Glu Ala Arg Arg Arg Thr Arg Glu Phe Glu Asp Arg Asp Arg Ser His 
145                 150                 155                 160 


Arg Glu Glu Met Glu Val Arg Val Ser Gln Leu Leu Ala Val Thr Gly 
                165                 170                 175     


Lys Lys Thr Thr Arg Pro 
            180         


<210>  1630
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBLB__Homo_sapiens__NP_733762

<400>  1630

Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys 
        35                  40                  45              


Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His 
            340                 345                 350         


Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val 
        755                 760                 765             


Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro 
    770                 775                 780                 


Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser 
785                 790                 795                 800 


Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala 
                805                 810                 815     


Leu Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu 
            820                 825                 830         


Ile Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly 
        835                 840                 845             


Gln Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser 
    850                 855                 860                 


Gly Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val 
865                 870                 875                 880 


Lys Thr Asn Arg Thr Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser 
                885                 890                 895     


Asp Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg 
            900                 905                 910         


Thr Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala 
        915                 920                 925             


Leu Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr 
    930                 935                 940                 


Ala Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val 
945                 950                 955                 960 


Glu Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val 
                965                 970                 975     


Ser Pro Arg Leu Asn Leu 
            980         


<210>  1631
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBL__Homo_sapiens__NP_005179

<400>  1631

Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg 
                85                  90                  95      


Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln 
        115                 120                 125             


Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu 
            340                 345                 350         


Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr 
625                 630                 635                 640 


Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu 
    850                 855                 860                 


Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile 
865                 870                 875                 880 


Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val 
                885                 890                 895     


Ser Ile Ser Ser Pro Ala His Val Ala Thr 
            900                 905     


<210>  1632
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBLL1__Homo_sapiens__NP_001271220

<400>  1632

Met Asp His Thr Asp Asn Glu Leu Gln Gly Thr Asn Ser Ser Gly Ser 
1               5                   10                  15      


Leu Gly Gly Leu Asp Val Arg Arg Arg Ile Pro Ile Lys Leu Ile Ser 
            20                  25                  30          


Lys Gln Ala Asn Lys Ala Lys Pro Ala Pro Arg Thr Gln Arg Thr Ile 
        35                  40                  45              


Asn Arg Met Pro Ala Lys Ala Pro Pro Gly Asp Glu Gly Phe Asp Tyr 
    50                  55                  60                  


Asn Glu Glu Glu Arg Tyr Asp Cys Lys Gly Gly Glu Leu Phe Ala Asn 
65                  70                  75                  80  


Gln Arg Arg Phe Pro Gly His Leu Phe Trp Asp Phe Gln Ile Asn Ile 
                85                  90                  95      


Leu Gly Glu Lys Asp Asp Thr Pro Val His Phe Cys Asp Lys Cys Gly 
            100                 105                 110         


Leu Pro Ile Lys Ile Tyr Gly Arg Met Ile Pro Cys Lys His Val Phe 
        115                 120                 125             


Cys Tyr Asp Cys Ala Ile Leu His Glu Lys Lys Gly Asp Lys Met Cys 
    130                 135                 140                 


Pro Gly Cys Ser Asp Pro Val Gln Arg Ile Glu Gln Cys Thr Arg Gly 
145                 150                 155                 160 


Ser Leu Phe Met Cys Ser Ile Val Gln Gly Cys Lys Arg Thr Tyr Leu 
                165                 170                 175     


Ser Gln Arg Asp Leu Gln Ala His Ile Asn His Arg His Met Arg Ala 
            180                 185                 190         


Gly Lys Pro Val Thr Arg Ala Ser Leu Glu Asn Val His Pro Pro Ile 
        195                 200                 205             


Ala Pro Pro Pro Thr Glu Ile Pro Glu Arg Phe Ile Met Pro Pro Asp 
    210                 215                 220                 


Lys His His Met Ser His Ile Pro Pro Lys Gln His Ile Met Met Pro 
225                 230                 235                 240 


Pro Pro Pro Leu Gln His Val Pro His Glu His Tyr Asn Gln Pro His 
                245                 250                 255     


Glu Asp Ile Arg Ala Pro Pro Ala Glu Leu Ser Met Ala Pro Pro Pro 
            260                 265                 270         


Pro Arg Ser Val Ser Gln Glu Thr Phe Arg Ile Ser Thr Arg Lys His 
        275                 280                 285             


Ser Asn Leu Ile Thr Val Pro Ile Gln Asp Asp Ser Asn Ser Gly Ala 
    290                 295                 300                 


Arg Glu Pro Pro Pro Pro Ala Pro Ala Pro Ala His His His Pro Glu 
305                 310                 315                 320 


Tyr Gln Gly Gln Pro Val Val Ser His Pro His His Ile Met Pro Pro 
                325                 330                 335     


Gln Gln His Tyr Ala Pro Pro Pro Pro Pro Pro Pro Pro Ile Ser His 
            340                 345                 350         


Pro Met Pro His Pro Pro Gln Ala Ala Gly Thr Pro His Leu Val Tyr 
        355                 360                 365             


Ser Gln Ala Pro Pro Pro Pro Met Thr Ser Ala Pro Pro Pro Ile Thr 
    370                 375                 380                 


Pro Pro Pro Gly His Ile Ile Ala Gln Met Pro Pro Tyr Met Asn His 
385                 390                 395                 400 


Pro Pro Pro Gly Pro Pro Pro Pro Gln His Gly Gly Pro Pro Val Thr 
                405                 410                 415     


Ala Pro Pro Pro His His Tyr Asn Pro Asn Ser Leu Pro Gln Phe Thr 
            420                 425                 430         


Glu Asp Gln Gly Thr Leu Ser Pro Pro Phe Thr Gln Pro Gly Gly Met 
        435                 440                 445             


Ser Pro Gly Ile Trp Pro Ala Pro Arg Gly Pro Pro Pro Pro Pro Arg 
    450                 455                 460                 


Leu Gln Gly Pro Pro Ser Gln Thr Pro Leu Pro Gly Pro His His Pro 
465                 470                 475                 480 


Asp Gln Thr Arg Tyr Arg Pro Tyr Tyr Gln 
                485                 490 


<210>  1633
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBLN1__Homo_sapiens__NP_004343

<400>  1633

Met Leu Gly Val Leu Glu Leu Leu Leu Leu Gly Ala Ala Trp Leu Ala 
1               5                   10                  15      


Gly Pro Ala Arg Gly Gln Asn Glu Thr Glu Pro Ile Val Leu Glu Gly 
            20                  25                  30          


Lys Cys Leu Val Val Cys Asp Ser Asn Pro Thr Ser Asp Pro Thr Gly 
        35                  40                  45              


Thr Ala Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe 
    50                  55                  60                  


Ser Ala Ile Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg 
65                  70                  75                  80  


Thr Met Ile Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn Asn 
                85                  90                  95      


Phe Asp Ser Glu Arg Ser Thr Phe Ile Ala Pro Arg Lys Gly Ile Tyr 
            100                 105                 110         


Ser Phe Asn Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln 
        115                 120                 125             


Val Ser Leu Met Leu Asn Gly Trp Pro Val Ile Ser Ala Phe Ala Gly 
    130                 135                 140                 


Asp Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Ile Gln 
145                 150                 155                 160 


Met Glu Lys Gly Asp Arg Ala Tyr Leu Lys Leu Glu Arg Gly Asn Leu 
                165                 170                 175     


Met Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro 
            180                 185                 190         


Leu 
    


<210>  1634
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBLN2__Homo_sapiens__XP_011524128

<400>  1634

Met Gln Ala Pro Gly Arg Gly Pro Leu Gly Leu Arg Leu Met Met Pro 
1               5                   10                  15      


Gly Arg Arg Gly Ala Leu Arg Glu Pro Gly Gly Cys Gly Ser Cys Leu 
            20                  25                  30          


Gly Val Ala Leu Ala Leu Leu Leu Leu Leu Leu Pro Ala Cys Cys Pro 
        35                  40                  45              


Val Arg Ala Gln Asn Asp Thr Glu Pro Ile Val Leu Glu Gly Lys Cys 
    50                  55                  60                  


Leu Val Val Cys Asp Ser Ser Pro Ser Ala Asp Gly Ala Val Thr Ser 
65                  70                  75                  80  


Ser Leu Gly Ile Ser Val Arg Ser Gly Ser Ala Lys Val Ala Phe Ser 
                85                  90                  95      


Ala Thr Arg Ser Thr Asn His Glu Pro Ser Glu Met Ser Asn Arg Thr 
            100                 105                 110         


Met Thr Ile Tyr Phe Asp Gln Val Leu Val Asn Ile Gly Asn His Phe 
        115                 120                 125             


Asp Leu Ala Ser Ser Ile Phe Val Ala Pro Arg Lys Gly Ile Tyr Ser 
    130                 135                 140                 


Phe Ser Phe His Val Val Lys Val Tyr Asn Arg Gln Thr Ile Gln Val 
145                 150                 155                 160 


Ser Leu Met Gln Asn Gly Tyr Pro Val Ile Ser Ala Phe Ala Gly Asp 
                165                 170                 175     


Gln Asp Val Thr Arg Glu Ala Ala Ser Asn Gly Val Leu Leu Leu Met 
            180                 185                 190         


Glu Arg Glu Asp Lys Val His Leu Lys Leu Glu Arg Gly Asn Leu Met 
        195                 200                 205             


Gly Gly Trp Lys Tyr Ser Thr Phe Ser Gly Phe Leu Val Phe Pro Leu 
    210                 215                 220                 


<210>  1635
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBLN4__Homo_sapiens__NP_542184

<400>  1635

Met Gly Ser Gly Arg Arg Ala Leu Ser Ala Val Pro Ala Val Leu Leu 
1               5                   10                  15      


Val Leu Thr Leu Pro Gly Leu Pro Val Trp Ala Gln Asn Asp Thr Glu 
            20                  25                  30          


Pro Ile Val Leu Glu Gly Lys Cys Leu Val Val Cys Asp Ser Asn Pro 
        35                  40                  45              


Ala Thr Asp Ser Lys Gly Ser Ser Ser Ser Pro Leu Gly Ile Ser Val 
    50                  55                  60                  


Arg Ala Ala Asn Ser Lys Val Ala Phe Ser Ala Val Arg Ser Thr Asn 
65                  70                  75                  80  


His Glu Pro Ser Glu Met Ser Asn Lys Thr Arg Ile Ile Tyr Phe Asp 
                85                  90                  95      


Gln Ile Leu Val Asn Val Gly Asn Phe Phe Thr Leu Glu Ser Val Phe 
            100                 105                 110         


Val Ala Pro Arg Lys Gly Ile Tyr Ser Phe Ser Phe His Val Ile Lys 
        115                 120                 125             


Val Tyr Gln Ser Gln Thr Ile Gln Val Asn Leu Met Leu Asn Gly Lys 
    130                 135                 140                 


Pro Val Ile Ser Ala Phe Ala Gly Asp Lys Asp Val Thr Arg Glu Ala 
145                 150                 155                 160 


Ala Thr Asn Gly Val Leu Leu Tyr Leu Asp Lys Glu Asp Lys Val Tyr 
                165                 170                 175     


Leu Lys Leu Glu Lys Gly Asn Leu Val Gly Gly Trp Gln Tyr Ser Thr 
            180                 185                 190         


Phe Ser Gly Phe Leu Val Phe Pro Leu 
        195                 200     


<210>  1636
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBR1__Homo_sapiens__NP_001748

<400>  1636

Met Ser Ser Gly Ile His Val Ala Leu Val Thr Gly Gly Asn Lys Gly 
1               5                   10                  15      


Ile Gly Leu Ala Ile Val Arg Asp Leu Cys Arg Leu Phe Ser Gly Asp 
            20                  25                  30          


Val Val Leu Thr Ala Arg Asp Val Thr Arg Gly Gln Ala Ala Val Gln 
        35                  40                  45              


Gln Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile 
    50                  55                  60                  


Asp Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu 
65                  70                  75                  80  


Tyr Gly Gly Leu Asp Val Leu Val Asn Asn Ala Gly Ile Ala Phe Lys 
                85                  90                  95      


Val Ala Asp Pro Thr Pro Phe His Ile Gln Ala Glu Val Thr Met Lys 
            100                 105                 110         


Thr Asn Phe Phe Gly Thr Arg Asp Val Cys Thr Glu Leu Leu Pro Leu 
        115                 120                 125             


Ile Lys Pro Gln Gly Arg Val Val Asn Val Ser Ser Ile Met Ser Val 
    130                 135                 140                 


Arg Ala Leu Lys Ser Cys Ser Pro Glu Leu Gln Gln Lys Phe Arg Ser 
145                 150                 155                 160 


Glu Thr Ile Thr Glu Glu Glu Leu Val Gly Leu Met Asn Lys Phe Val 
                165                 170                 175     


Glu Asp Thr Lys Lys Gly Val His Gln Lys Glu Gly Trp Pro Ser Ser 
            180                 185                 190         


Ala Tyr Gly Val Thr Lys Ile Gly Val Thr Val Leu Ser Arg Ile His 
        195                 200                 205             


Ala Arg Lys Leu Ser Glu Gln Arg Lys Gly Asp Lys Ile Leu Leu Asn 
    210                 215                 220                 


Ala Cys Cys Pro Gly Trp Val Arg Thr Asp Met Ala Gly Pro Lys Ala 
225                 230                 235                 240 


Thr Lys Ser Pro Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu 
                245                 250                 255     


Leu Pro Pro Asp Ala Glu Gly Pro His Gly Gln Phe Val Ser Glu Lys 
            260                 265                 270         


Arg Val Glu Gln Trp 
        275         


<210>  1637
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBR3__Homo_sapiens__NP_001227

<400>  1637

Met Ser Ser Cys Ser Arg Val Ala Leu Val Thr Gly Ala Asn Arg Gly 
1               5                   10                  15      


Ile Gly Leu Ala Ile Ala Arg Glu Leu Cys Arg Gln Phe Ser Gly Asp 
            20                  25                  30          


Val Val Leu Thr Ala Arg Asp Val Ala Arg Gly Gln Ala Ala Val Gln 
        35                  40                  45              


Gln Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile 
    50                  55                  60                  


Asp Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu 
65                  70                  75                  80  


Tyr Gly Gly Leu Asn Val Leu Val Asn Asn Ala Ala Val Ala Phe Lys 
                85                  90                  95      


Ser Asp Asp Pro Met Pro Phe Asp Ile Lys Ala Glu Met Thr Leu Lys 
            100                 105                 110         


Thr Asn Phe Phe Ala Thr Arg Asn Met Cys Asn Glu Leu Leu Pro Ile 
        115                 120                 125             


Met Lys Pro His Gly Arg Val Val Asn Ile Ser Ser Leu Gln Cys Leu 
    130                 135                 140                 


Arg Ala Phe Glu Asn Cys Ser Glu Asp Leu Gln Glu Arg Phe His Ser 
145                 150                 155                 160 


Glu Thr Leu Thr Glu Gly Asp Leu Val Asp Leu Met Lys Lys Phe Val 
                165                 170                 175     


Glu Asp Thr Lys Asn Glu Val His Glu Arg Glu Gly Trp Pro Asn Ser 
            180                 185                 190         


Pro Tyr Gly Val Ser Lys Leu Gly Val Thr Val Leu Ser Arg Ile Leu 
        195                 200                 205             


Ala Arg Arg Leu Asp Glu Lys Arg Lys Ala Asp Arg Ile Leu Val Asn 
    210                 215                 220                 


Ala Cys Cys Pro Gly Pro Val Lys Thr Asp Met Asp Gly Lys Asp Ser 
225                 230                 235                 240 


Ile Arg Thr Val Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu 
                245                 250                 255     


Leu Pro Pro Asp Ala Thr Glu Pro Gln Gly Gln Leu Val His Asp Lys 
            260                 265                 270         


Val Val Gln Asn Trp 
        275         


<210>  1638
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBR4__Homo_sapiens__NP_116172

<400>  1638

Met Asp Lys Val Cys Ala Val Phe Gly Gly Ser Arg Gly Ile Gly Arg 
1               5                   10                  15      


Ala Val Ala Gln Leu Met Ala Arg Lys Gly Tyr Arg Leu Ala Val Ile 
            20                  25                  30          


Ala Arg Asn Leu Glu Gly Ala Lys Ala Ala Ala Gly Asp Leu Gly Gly 
        35                  40                  45              


Asp His Leu Ala Phe Ser Cys Asp Val Ala Lys Glu His Asp Val Gln 
    50                  55                  60                  


Asn Thr Phe Glu Glu Leu Glu Lys His Leu Gly Arg Val Asn Phe Leu 
65                  70                  75                  80  


Val Asn Ala Ala Gly Ile Asn Arg Asp Gly Leu Leu Val Arg Thr Lys 
                85                  90                  95      


Thr Glu Asp Met Val Ser Gln Leu His Thr Asn Leu Leu Gly Ser Met 
            100                 105                 110         


Leu Thr Cys Lys Ala Ala Met Arg Thr Met Ile Gln Gln Gln Gly Gly 
        115                 120                 125             


Ser Ile Val Asn Val Gly Ser Ile Val Gly Leu Lys Gly Asn Ser Gly 
    130                 135                 140                 


Gln Ser Val Tyr Ser Ala Ser Lys Gly Gly Leu Val Gly Phe Ser Arg 
145                 150                 155                 160 


Ala Leu Ala Lys Glu Val Ala Arg Lys Lys Ile Arg Val Asn Val Val 
                165                 170                 175     


Ala Pro Gly Phe Val His Thr Asp Met Thr Lys Asp Leu Lys Glu Glu 
            180                 185                 190         


His Leu Lys Lys Asn Ile Pro Leu Gly Arg Phe Gly Glu Thr Ile Glu 
        195                 200                 205             


Val Ala His Ala Val Val Phe Leu Leu Glu Ser Pro Tyr Ile Thr Gly 
    210                 215                 220                 


His Val Leu Val Val Asp Gly Gly Leu Gln Leu Ile Leu 
225                 230                 235         


<210>  1639
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBS__Homo_sapiens__XP_011528084

<400>  1639

Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Cys Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg Val Gln Glu 
                405                 410                 415     


Leu Gly Leu Ser Ala Pro Leu Thr Val Leu Pro Thr Ile Thr Cys Gly 
            420                 425                 430         


His Thr Ile Glu Ile Leu Arg Glu Lys Gly Phe Asp Gln Ala Pro Val 
        435                 440                 445             


Val Asp Glu Ala Gly Val Ile Leu Gly Met Val Thr Leu Gly Asn Met 
    450                 455                 460                 


Leu Ser Ser Leu Leu Ala Gly Lys Val Gln Pro Ser Asp Gln Val Gly 
465                 470                 475                 480 


Lys Val Ile Tyr Lys Gln Phe Lys Gln Ile Arg Leu Thr Asp Thr Leu 
                485                 490                 495     


Gly Arg Leu Ser His Ile Leu Glu Met Asp His Phe Ala Leu Val Val 
            500                 505                 510         


His Glu Gln Ile Gln Ser Gln Asp Gln Ala Trp Ala Gly Val Val Gly 
        515                 520                 525             


Gly Pro Ala Asp His Ser Thr Gly Lys Ser Ser Gln Arg Gln Met Val 
    530                 535                 540                 


Phe Gly Val Val Thr Ala Ile Asp Leu Leu Asn Phe Val Ala Ala Gln 
545                 550                 555                 560 


Glu Arg Asp Gln Lys 
                565 


<210>  1640
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX1__Homo_sapiens__NP_006798

<400>  1640

Met Gly Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val 
            20                  25                  30          


Lys Gly Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu 
        35                  40                  45              


Asp Asn Thr Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile 
    50                  55                  60                  


Ala Glu Phe Leu Gln Ser Gln Lys Thr Ala His Glu Thr Asp Lys Ser 
65                  70                  75                  80  


Glu Gly Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu 
                85                  90                  95      


Glu Ser Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly 
            100                 105                 110         


Phe Ala Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Thr Asp Ser 
        115                 120                 125             


Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asn Ser Asp Glu Ala 
    130                 135                 140                 


Asp Leu Val Pro Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Val Val 
145                 150                 155                 160 


Ile Ser Phe Tyr Glu Glu Arg Leu Thr Trp His Ser Tyr Pro Ser Glu 
                165                 170                 175     


Asp Asp Asp Lys Lys Asp Asp Lys Asn 
            180                 185 


<210>  1641
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX2__Homo_sapiens__NP_005180

<400>  1641

Met Glu Glu Leu Ser Ser Val Gly Glu Gln Val Phe Ala Ala Glu Cys 
1               5                   10                  15      


Ile Leu Ser Lys Arg Leu Arg Lys Gly Lys Leu Glu Tyr Leu Val Lys 
            20                  25                  30          


Trp Arg Gly Trp Ser Ser Lys His Asn Ser Trp Glu Pro Glu Glu Asn 
        35                  40                  45              


Ile Leu Asp Pro Arg Leu Leu Leu Ala Phe Gln Lys Lys Glu His Glu 
    50                  55                  60                  


Lys Glu Val Gln Asn Arg Lys Arg Gly Lys Arg Pro Arg Gly Arg Pro 
65                  70                  75                  80  


Arg Lys Leu Thr Ala Met Ser Ser Cys Ser Arg Arg Ser Lys Leu Lys 
                85                  90                  95      


Glu Pro Asp Ala Pro Ser Lys Ser Lys Ser Ser Ser Ser Ser Ser Ser 
            100                 105                 110         


Ser Thr Ser Ser Ser Ser Ser Ser Asp Glu Glu Asp Asp Ser Asp Leu 
        115                 120                 125             


Asp Ala Lys Arg Gly Pro Arg Gly Arg Glu Thr His Pro Val Pro Gln 
    130                 135                 140                 


Lys Lys Ala Gln Ile Leu Val Ala Lys Pro Glu Leu Lys Asp Pro Ile 
145                 150                 155                 160 


Arg Lys Lys Arg Gly Arg Lys Pro Leu Pro Pro Glu Gln Lys Ala Thr 
                165                 170                 175     


Arg Arg Pro Val Ser Leu Ala Lys Val Leu Lys Thr Ala Arg Lys Asp 
            180                 185                 190         


Leu Gly Ala Pro Ala Ser Lys Leu Pro Pro Pro Leu Ser Ala Pro Val 
        195                 200                 205             


Ala Gly Leu Ala Ala Leu Lys Ala His Ala Lys Glu Ala Cys Gly Gly 
    210                 215                 220                 


Pro Ser Ala Met Ala Thr Pro Glu Asn Leu Ala Ser Leu Met Lys Gly 
225                 230                 235                 240 


Met Ala Ser Ser Pro Gly Arg Gly Gly Ile Ser Trp Gln Ser Ser Ile 
                245                 250                 255     


Val His Tyr Met Asn Arg Met Thr Gln Ser Gln Ala Gln Ala Ala Ser 
            260                 265                 270         


Arg Leu Ala Leu Lys Ala Gln Ala Thr Asn Lys Cys Gly Leu Gly Leu 
        275                 280                 285             


Asp Leu Lys Val Arg Thr Gln Lys Gly Glu Leu Gly Met Ser Pro Pro 
    290                 295                 300                 


Gly Ser Lys Ile Pro Lys Ala Pro Ser Gly Gly Ala Val Glu Gln Lys 
305                 310                 315                 320 


Val Gly Asn Thr Gly Gly Pro Pro His Thr His Gly Ala Ser Arg Val 
                325                 330                 335     


Pro Ala Gly Cys Pro Gly Pro Gln Pro Ala Pro Thr Gln Glu Leu Ser 
            340                 345                 350         


Leu Gln Val Leu Asp Leu Gln Ser Val Lys Asn Gly Met Pro Gly Val 
        355                 360                 365             


Gly Leu Leu Ala Arg His Ala Thr Ala Thr Lys Gly Val Pro Ala Thr 
    370                 375                 380                 


Asn Pro Ala Pro Gly Lys Gly Thr Gly Ser Gly Leu Ile Gly Ala Ser 
385                 390                 395                 400 


Gly Ala Thr Met Pro Thr Asp Thr Ser Lys Ser Glu Lys Leu Ala Ser 
                405                 410                 415     


Arg Ala Val Ala Pro Pro Thr Pro Ala Ser Lys Arg Asp Cys Val Lys 
            420                 425                 430         


Gly Ser Ala Thr Pro Ser Gly Gln Glu Ser Arg Thr Ala Pro Gly Glu 
        435                 440                 445             


Ala Arg Lys Ala Ala Thr Leu Pro Glu Met Ser Ala Gly Glu Glu Ser 
    450                 455                 460                 


Ser Ser Ser Asp Ser Asp Pro Asp Ser Ala Ser Pro Pro Ser Thr Gly 
465                 470                 475                 480 


Gln Asn Pro Ser Val Ser Val Gln Thr Ser Gln Asp Trp Lys Pro Thr 
                485                 490                 495     


Arg Ser Leu Ile Glu His Val Phe Val Thr Asp Val Thr Ala Asn Leu 
            500                 505                 510         


Ile Thr Val Thr Val Lys Glu Ser Pro Thr Ser Val Gly Phe Phe Asn 
        515                 520                 525             


Leu Arg His Tyr 
    530         


<210>  1642
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX3__Homo_sapiens__NP_009207

<400>  1642

Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210>  1643
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX4__Homo_sapiens__NP_003646

<400>  1643

Met Glu Leu Pro Ala Val Gly Glu His Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Glu Lys Lys Arg Ile Arg Lys Gly Arg Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Arg Gly Trp Ser Pro Lys Tyr Asn Thr Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Arg Glu Arg Gln Glu 
    50                  55                  60                  


Gln Leu Met Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Pro Leu Val 
65                  70                  75                  80  


Val Gln Val Pro Thr Phe Ala Arg Arg Ser Asn Val Leu Thr Gly Leu 
                85                  90                  95      


Gln Asp Ser Ser Thr Asp Asn Arg Ala Lys Leu Asp Leu Gly Ala Gln 
            100                 105                 110         


Gly Lys Gly Gln Gly His Gln Tyr Glu Leu Asn Ser Lys Lys His His 
        115                 120                 125             


Gln Tyr Gln Pro His Ser Lys Glu Arg Ala Gly Lys Pro Pro Pro Pro 
    130                 135                 140                 


Gly Lys Ser Gly Lys Tyr Tyr Tyr Gln Leu Asn Ser Lys Lys His His 
145                 150                 155                 160 


Pro Tyr Gln Pro Asp Pro Lys Met Tyr Asp Leu Gln Tyr Gln Gly Gly 
                165                 170                 175     


His Lys Glu Ala Pro Ser Pro Thr Cys Pro Asp Leu Gly Ala Lys Ser 
            180                 185                 190         


His Pro Pro Asp Lys Trp Ala Gln Gly Ala Gly Ala Lys Gly Tyr Leu 
        195                 200                 205             


Gly Ala Val Lys Pro Leu Ala Gly Ala Ala Gly Ala Pro Gly Lys Gly 
    210                 215                 220                 


Ser Glu Lys Gly Pro Pro Asn Gly Met Met Pro Ala Pro Lys Glu Ala 
225                 230                 235                 240 


Val Thr Gly Asn Gly Ile Gly Gly Lys Met Lys Ile Val Lys Asn Lys 
                245                 250                 255     


Asn Lys Asn Gly Arg Ile Val Ile Val Met Ser Lys Tyr Met Glu Asn 
            260                 265                 270         


Gly Met Gln Ala Val Lys Ile Lys Ser Gly Glu Val Ala Glu Gly Glu 
        275                 280                 285             


Ala Arg Ser Pro Ser His Lys Lys Arg Ala Ala Asp Glu Arg His Pro 
    290                 295                 300                 


Pro Ala Asp Arg Thr Phe Lys Lys Ala Ala Gly Ala Glu Glu Lys Lys 
305                 310                 315                 320 


Val Glu Ala Pro Pro Lys Arg Arg Glu Glu Glu Val Ser Gly Val Ser 
                325                 330                 335     


Asp Pro Gln Pro Gln Asp Ala Gly Ser Arg Lys Leu Ser Pro Thr Lys 
            340                 345                 350         


Glu Ala Phe Gly Glu Gln Pro Leu Gln Leu Thr Thr Lys Pro Asp Leu 
        355                 360                 365             


Leu Ala Trp Asp Pro Ala Arg Asn Thr His Pro Pro Ser His His Pro 
    370                 375                 380                 


His Pro His Pro His His His His His His His His His His His His 
385                 390                 395                 400 


Ala Val Gly Leu Asn Leu Ser His Val Arg Lys Arg Cys Leu Ser Glu 
                405                 410                 415     


Thr His Gly Glu Arg Glu Pro Cys Lys Lys Arg Leu Thr Ala Arg Ser 
            420                 425                 430         


Ile Ser Thr Pro Thr Cys Leu Gly Gly Ser Pro Ala Ala Glu Arg Pro 
        435                 440                 445             


Ala Asp Leu Pro Pro Ala Ala Ala Leu Pro Gln Pro Glu Val Ile Leu 
    450                 455                 460                 


Leu Asp Ser Asp Leu Asp Glu Pro Ile Asp Leu Arg Cys Val Lys Thr 
465                 470                 475                 480 


Arg Ser Glu Ala Gly Glu Pro Pro Ser Ser Leu Gln Val Lys Pro Glu 
                485                 490                 495     


Thr Pro Ala Ser Ala Ala Val Ala Val Ala Ala Ala Ala Ala Pro Thr 
            500                 505                 510         


Thr Thr Ala Glu Lys Pro Pro Ala Glu Ala Gln Asp Glu Pro Ala Glu 
        515                 520                 525             


Ser Leu Ser Glu Phe Lys Pro Phe Phe Gly Asn Ile Ile Ile Thr Asp 
    530                 535                 540                 


Val Thr Ala Asn Cys Leu Thr Val Thr Phe Lys Glu Tyr Val Thr Val 
545                 550                 555                 560 


<210>  1644
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX5__Homo_sapiens__NP_001120793

<400>  1644

Met Gly Lys Lys Thr Lys Arg Thr Ala Asp Ser Ser Ser Ser Glu Asp 
1               5                   10                  15      


Glu Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys 
            20                  25                  30          


Gly Gln Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Glu Glu His 
        35                  40                  45              


Asn Thr Trp Glu Pro Glu Lys Asn Leu Asp Cys Pro Glu Leu Ile Ser 
    50                  55                  60                  


Glu Phe Met Lys Lys Tyr Lys Lys Met Lys Glu Gly Glu Asn Asn Lys 
65                  70                  75                  80  


Pro Arg Glu Lys Ser Glu Ser Asn Lys Arg Lys Ser Asn Phe Ser Asn 
                85                  90                  95      


Ser Ala Asp Asp Ile Lys Ser Lys Lys Lys Arg Glu Gln Ser Asn Asp 
            100                 105                 110         


Ile Ala Arg Gly Phe Glu Arg Gly Leu Glu Pro Glu Lys Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Cys Gly Asp Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Thr Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Val Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ala 
                165                 170                 175     


Tyr Pro Glu Asp Ala Glu Asn Lys Glu Lys Glu Thr Ala Lys Ser 
            180                 185                 190     


<210>  1645
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX6__Homo_sapiens__NP_001290423

<400>  1645

Met Glu Leu Ser Ala Val Gly Glu Arg Val Phe Ala Ala Glu Ser Ile 
1               5                   10                  15      


Ile Lys Arg Arg Ile Arg Lys Gly Arg Ile Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Ala Ile Lys Tyr Ser Thr Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Ser Arg Leu Ile Ala Ala Phe Glu Gln Lys Glu Arg Glu Arg 
    50                  55                  60                  


Glu Leu Tyr Gly Pro Lys Lys Arg Gly Pro Lys Pro Lys Thr Phe Leu 
65                  70                  75                  80  


Leu Lys Pro Ser Ala Ser Ala Ser Ser Pro Lys Leu His Ser Ser Ala 
                85                  90                  95      


Ala Val His Arg Leu Lys Lys Asp Ile Arg Arg Cys His Arg Met Ser 
            100                 105                 110         


Arg Arg Pro Leu Pro Arg Pro Asp Pro Gln Gly Gly Ser Pro Gly Leu 
        115                 120                 125             


Arg Pro Pro Ile Ser Pro Phe Ser Glu Thr Val Arg Ile Ile Asn Arg 
    130                 135                 140                 


Lys Val Lys Pro Arg Glu Pro Lys Arg Asn Arg Ile Ile Leu Asn Leu 
145                 150                 155                 160 


Lys Val Ile Asp Lys Gly Ala Gly Gly Gly Gly Ala Gly Gln Gly Ala 
                165                 170                 175     


Gly Ala Leu Ala Arg Pro Lys Val Pro Ser Arg Asn Arg Val Ile Gly 
            180                 185                 190         


Lys Ser Lys Lys Phe Ser Glu Ser Val Leu Arg Thr Gln Ile Arg His 
        195                 200                 205             


Met Lys Phe Gly Ala Phe Ala Leu Tyr Lys Pro Pro Pro Ala Pro Leu 
    210                 215                 220                 


Val Ala Pro Ser Pro Gly Lys Ala Glu Ala Ser Ala Pro Gly Pro Gly 
225                 230                 235                 240 


Leu Leu Leu Ala Ala Pro Ala Ala Pro Tyr Asp Ala Arg Ser Ser Gly 
                245                 250                 255     


Ser Ser Gly Cys Pro Ser Pro Thr Pro Gln Ser Ser Asp Pro Asp Asp 
            260                 265                 270         


Thr Pro Pro Lys Leu Leu Pro Glu Thr Val Ser Pro Ser Ala Pro Ser 
        275                 280                 285             


Trp Arg Glu Pro Glu Val Leu Asp Leu Ser Leu Pro Pro Glu Ser Ala 
    290                 295                 300                 


Ala Thr Ser Lys Arg Ala Pro Pro Glu Val Thr Ala Ala Ala Gly Pro 
305                 310                 315                 320 


Ala Pro Pro Thr Ala Pro Glu Pro Ala Gly Ala Ser Ser Glu Pro Glu 
                325                 330                 335     


Ala Gly Asp Trp Arg Pro Glu Met Ser Pro Cys Ser Asn Val Val Val 
            340                 345                 350         


Thr Asp Val Thr Ser Asn Leu Leu Thr Val Thr Ile Lys Glu Phe Cys 
        355                 360                 365             


Asn Pro Glu Asp Phe Glu Lys Val Ala Ala Gly Val Ala Gly Ala Ala 
    370                 375                 380                 


Gly Gly Gly Gly Ser Ile Gly Ala Ser Lys 
385                 390                 


<210>  1646
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX7__Homo_sapiens__NP_783640

<400>  1646

Met Glu Leu Ser Ala Ile Gly Glu Gln Val Phe Ala Val Glu Ser Ile 
1               5                   10                  15      


Arg Lys Lys Arg Val Arg Lys Gly Lys Val Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Pro Pro Lys Tyr Ser Thr Trp Glu Pro Glu Glu His Ile 
        35                  40                  45              


Leu Asp Pro Arg Leu Val Met Ala Tyr Glu Glu Lys Glu Glu Arg Asp 
    50                  55                  60                  


Arg Ala Ser Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Arg Leu Leu 
65                  70                  75                  80  


Leu Gln Arg Leu Tyr Ser Met Asp Leu Arg Ser Ser His Lys Ala Lys 
                85                  90                  95      


Gly Lys Glu Lys Leu Cys Phe Ser Leu Thr Cys Pro Leu Gly Ser Gly 
            100                 105                 110         


Ser Pro Glu Gly Val Val Lys Ala Gly Ala Pro Glu Leu Val Asp Lys 
        115                 120                 125             


Gly Pro Leu Val Pro Thr Leu Pro Phe Pro Leu Arg Lys Pro Arg Lys 
    130                 135                 140                 


Ala His Lys Tyr Leu Arg Leu Ser Arg Lys Lys Phe Pro Pro Arg Gly 
145                 150                 155                 160 


Pro Asn Leu Glu Ser His Ser His Arg Arg Glu Leu Phe Leu Gln Glu 
                165                 170                 175     


Pro Pro Ala Pro Asp Val Leu Gln Ala Ala Gly Glu Trp Glu Pro Ala 
            180                 185                 190         


Ala Gln Pro Pro Glu Glu Glu Ala Asp Ala Asp Leu Ala Glu Gly Pro 
        195                 200                 205             


Pro Pro Trp Thr Pro Ala Leu Pro Ser Ser Glu Val Thr Val Thr Asp 
    210                 215                 220                 


Ile Thr Ala Asn Ser Ile Thr Val Thr Phe Arg Glu Ala Gln Ala Ala 
225                 230                 235                 240 


Glu Gly Phe Phe Arg Asp Arg Ser Gly Lys Phe 
                245                 250     


<210>  1647
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBX8__Homo_sapiens__NP_065700

<400>  1647

Met Glu Leu Ser Ala Val Gly Glu Arg Val Phe Ala Ala Glu Ala Leu 
1               5                   10                  15      


Leu Lys Arg Arg Ile Arg Lys Gly Arg Met Glu Tyr Leu Val Lys Trp 
            20                  25                  30          


Lys Gly Trp Ser Gln Lys Tyr Ser Thr Trp Glu Pro Glu Glu Asn Ile 
        35                  40                  45              


Leu Asp Ala Arg Leu Leu Ala Ala Phe Glu Glu Arg Glu Arg Glu Met 
    50                  55                  60                  


Glu Leu Tyr Gly Pro Lys Lys Arg Gly Pro Lys Pro Lys Thr Phe Leu 
65                  70                  75                  80  


Leu Lys Ala Gln Ala Lys Ala Lys Ala Lys Thr Tyr Glu Phe Arg Ser 
                85                  90                  95      


Asp Ser Ala Arg Gly Ile Arg Ile Pro Tyr Pro Gly Arg Ser Pro Gln 
            100                 105                 110         


Asp Leu Ala Ser Thr Ser Arg Ala Arg Glu Gly Leu Arg Asn Met Gly 
        115                 120                 125             


Leu Ser Pro Pro Ala Ser Ser Thr Ser Thr Ser Ser Thr Cys Arg Ala 
    130                 135                 140                 


Glu Ala Pro Arg Asp Arg Asp Arg Asp Arg Asp Arg Asp Arg Glu Arg 
145                 150                 155                 160 


Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 
                165                 170                 175     


Glu Arg Glu Arg Gly Thr Ser Arg Val Asp Asp Lys Pro Ser Ser Pro 
            180                 185                 190         


Gly Asp Ser Ser Lys Lys Arg Gly Pro Lys Pro Arg Lys Glu Leu Pro 
        195                 200                 205             


Asp Pro Ser Gln Arg Pro Leu Gly Glu Pro Ser Ala Gly Leu Gly Glu 
    210                 215                 220                 


Tyr Leu Lys Gly Arg Lys Leu Asp Asp Thr Pro Ser Gly Ala Gly Lys 
225                 230                 235                 240 


Phe Pro Ala Gly His Ser Val Ile Gln Leu Ala Arg Arg Gln Asp Ser 
                245                 250                 255     


Asp Leu Val Gln Cys Gly Val Thr Ser Pro Ser Ser Ala Glu Ala Thr 
            260                 265                 270         


Gly Lys Leu Ala Val Asp Thr Phe Pro Ala Arg Val Ile Lys His Arg 
        275                 280                 285             


Ala Ala Phe Leu Glu Ala Lys Gly Gln Gly Ala Leu Asp Pro Asn Gly 
    290                 295                 300                 


Thr Arg Val Arg His Gly Ser Gly Pro Pro Ser Ser Gly Gly Gly Leu 
305                 310                 315                 320 


Tyr Arg Asp Met Gly Ala Gln Gly Gly Arg Pro Ser Leu Ile Ala Arg 
                325                 330                 335     


Ile Pro Val Ala Arg Ile Leu Gly Asp Pro Glu Glu Glu Ser Trp Ser 
            340                 345                 350         


Pro Ser Leu Thr Asn Leu Glu Lys Val Val Val Thr Asp Val Thr Ser 
        355                 360                 365             


Asn Phe Leu Thr Val Thr Ile Lys Glu Ser Asn Thr Asp Gln Gly Phe 
    370                 375                 380                 


Phe Lys Glu Lys Arg 
385                 


<210>  1648
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBY1__Homo_sapiens__NP_001002880

<400>  1648

Met Asp Lys Cys Gln Lys His Asp Val Glu Cys Glu Lys Pro Asp Ala 
1               5                   10                  15      


Asn Glu Asp Ser Leu Cys Asn Ser Val His Val Gln Trp Pro Gly Glu 
            20                  25                  30          


Gly Ser Thr Gly Phe Ala Phe Ile Arg Pro Lys Met Pro Phe Phe Gly 
        35                  40                  45              


Asn Thr Phe Ser Pro Lys Lys Thr Pro Pro Arg Lys Ser Ala Ser Leu 
    50                  55                  60                  


Ser Asn Leu His Ser Leu Asp Arg Ser Thr Arg Glu Val Glu Leu Gly 
65                  70                  75                  80  


Leu Glu Tyr Gly Ser Pro Thr Met Asn Leu Ala Gly Gln Ser Leu Lys 
                85                  90                  95      


Phe Glu Asn Gly Gln Trp Ile Ala Glu Thr Gly Val Ser Gly Gly Val 
            100                 105                 110         


Asp Arg Arg Glu Val Gln Arg Leu Arg Arg Arg Asn Gln Gln Leu Glu 
        115                 120                 125             


Glu Glu Asn Asn Leu Leu Arg Leu Lys Val Asp Ile Leu Leu Asp Met 
    130                 135                 140                 


Leu Ser Glu Ser Thr Ala Glu Ser His Leu Met Glu Lys Glu Leu Asp 
145                 150                 155                 160 


Glu Leu Arg Ile Ser Arg Lys Arg Lys 
                165                 


<210>  1649
<211>  951
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC2D1A__Homo_sapiens__NP_060191

<400>  1649

Met His Lys Arg Lys Gly Pro Pro Gly Pro Pro Gly Arg Gly Ala Ala 
1               5                   10                  15      


Ala Ala Arg Gln Leu Gly Leu Leu Val Asp Leu Ser Pro Asp Gly Leu 
            20                  25                  30          


Met Ile Pro Glu Asp Gly Ala Asn Asp Glu Glu Leu Glu Ala Glu Phe 
        35                  40                  45              


Leu Ala Leu Val Gly Gly Gln Pro Pro Ala Leu Glu Lys Leu Lys Gly 
    50                  55                  60                  


Lys Gly Pro Leu Pro Met Glu Ala Ile Glu Lys Met Ala Ser Leu Cys 
65                  70                  75                  80  


Met Arg Asp Pro Asp Glu Asp Glu Glu Glu Gly Thr Asp Glu Asp Asp 
                85                  90                  95      


Leu Glu Ala Asp Asp Asp Leu Leu Ala Glu Leu Asn Glu Val Leu Gly 
            100                 105                 110         


Glu Glu Gln Lys Ala Ser Glu Thr Pro Pro Pro Val Ala Gln Pro Lys 
        115                 120                 125             


Pro Glu Ala Pro His Pro Gly Leu Glu Thr Thr Leu Gln Glu Arg Leu 
    130                 135                 140                 


Ala Leu Tyr Gln Thr Ala Ile Glu Ser Ala Arg Gln Ala Gly Asp Ser 
145                 150                 155                 160 


Ala Lys Met Arg Arg Tyr Asp Arg Gly Leu Lys Thr Leu Glu Asn Leu 
                165                 170                 175     


Leu Ala Ser Ile Arg Lys Gly Asn Ala Ile Asp Glu Ala Asp Ile Pro 
            180                 185                 190         


Pro Pro Val Ala Ile Gly Lys Gly Pro Ala Ser Thr Pro Thr Tyr Ser 
        195                 200                 205             


Pro Ala Pro Thr Gln Pro Ala Pro Arg Ile Ala Ser Ala Pro Glu Pro 
    210                 215                 220                 


Arg Val Thr Leu Glu Gly Pro Ser Ala Thr Ala Pro Ala Ser Ser Pro 
225                 230                 235                 240 


Gly Leu Ala Lys Pro Gln Met Pro Pro Gly Pro Cys Ser Pro Gly Pro 
                245                 250                 255     


Leu Ala Gln Leu Gln Ser Arg Gln Arg Asp Tyr Lys Leu Ala Ala Leu 
            260                 265                 270         


His Ala Lys Gln Gln Gly Asp Thr Thr Ala Ala Ala Arg His Phe Arg 
        275                 280                 285             


Val Ala Lys Ser Phe Asp Ala Val Leu Glu Ala Leu Ser Arg Gly Glu 
    290                 295                 300                 


Pro Val Asp Leu Ser Cys Leu Pro Pro Pro Pro Asp Gln Leu Pro Pro 
305                 310                 315                 320 


Asp Pro Pro Ser Pro Pro Ser Gln Pro Pro Thr Pro Ala Thr Ala Pro 
                325                 330                 335     


Ser Thr Thr Glu Val Pro Pro Pro Pro Arg Thr Leu Leu Glu Ala Leu 
            340                 345                 350         


Glu Gln Arg Met Glu Arg Tyr Gln Val Ala Ala Ala Gln Ala Lys Ser 
        355                 360                 365             


Lys Gly Asp Gln Arg Lys Ala Arg Met His Glu Arg Ile Val Lys Gln 
    370                 375                 380                 


Tyr Gln Asp Ala Ile Arg Ala His Lys Ala Gly Arg Ala Val Asp Val 
385                 390                 395                 400 


Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile Gln Gly Leu Glu 
                405                 410                 415     


Ala Thr Lys Pro Thr Gln Gln Ser Leu Val Gly Val Leu Glu Thr Ala 
            420                 425                 430         


Met Lys Leu Ala Asn Gln Asp Glu Gly Pro Glu Asp Glu Glu Asp Glu 
        435                 440                 445             


Val Pro Lys Lys Gln Asn Ser Pro Val Ala Pro Thr Ala Gln Pro Lys 
    450                 455                 460                 


Ala Pro Pro Ser Arg Thr Pro Gln Ser Gly Ser Ala Pro Thr Ala Lys 
465                 470                 475                 480 


Ala Pro Pro Lys Ala Thr Ser Thr Arg Ala Gln Gln Gln Leu Ala Phe 
                485                 490                 495     


Leu Glu Gly Arg Lys Lys Gln Leu Leu Gln Ala Ala Leu Arg Ala Lys 
            500                 505                 510         


Gln Lys Asn Asp Val Glu Gly Ala Lys Met His Leu Arg Gln Ala Lys 
        515                 520                 525             


Gly Leu Glu Pro Met Leu Glu Ala Ser Arg Asn Gly Leu Pro Val Asp 
    530                 535                 540                 


Ile Thr Lys Val Pro Pro Ala Pro Val Asn Lys Asp Asp Phe Ala Leu 
545                 550                 555                 560 


Val Gln Arg Pro Gly Pro Gly Leu Ser Gln Glu Ala Ala Arg Arg Tyr 
                565                 570                 575     


Gly Glu Leu Thr Lys Leu Ile Arg Gln Gln His Glu Met Cys Leu Asn 
            580                 585                 590         


His Ser Asn Gln Phe Thr Gln Leu Gly Asn Ile Thr Glu Thr Thr Lys 
        595                 600                 605             


Phe Glu Lys Leu Ala Glu Asp Cys Lys Arg Ser Met Asp Ile Leu Lys 
    610                 615                 620                 


Gln Ala Phe Val Arg Gly Leu Pro Thr Pro Thr Ala Arg Phe Glu Gln 
625                 630                 635                 640 


Arg Thr Phe Ser Val Ile Lys Ile Phe Pro Asp Leu Ser Ser Asn Asp 
                645                 650                 655     


Met Leu Leu Phe Ile Val Lys Gly Ile Asn Leu Pro Thr Pro Pro Gly 
            660                 665                 670         


Leu Ser Pro Gly Asp Leu Asp Val Phe Val Arg Phe Asp Phe Pro Tyr 
        675                 680                 685             


Pro Asn Val Glu Glu Ala Gln Lys Asp Lys Thr Ser Val Ile Lys Asn 
    690                 695                 700                 


Thr Asp Ser Pro Glu Phe Lys Glu Gln Phe Lys Leu Cys Ile Asn Arg 
705                 710                 715                 720 


Ser His Arg Gly Phe Arg Arg Ala Ile Gln Thr Lys Gly Ile Lys Phe 
                725                 730                 735     


Glu Val Val His Lys Gly Gly Leu Phe Lys Thr Asp Arg Val Leu Gly 
            740                 745                 750         


Thr Ala Gln Leu Lys Leu Asp Ala Leu Glu Ile Ala Cys Glu Val Arg 
        755                 760                 765             


Glu Ile Leu Glu Val Leu Asp Gly Arg Arg Pro Thr Gly Gly Arg Leu 
    770                 775                 780                 


Glu Val Met Val Arg Ile Arg Glu Pro Leu Thr Ala Gln Gln Leu Glu 
785                 790                 795                 800 


Thr Thr Thr Glu Arg Trp Leu Val Ile Asp Pro Val Pro Ala Ala Val 
                805                 810                 815     


Pro Thr Gln Val Ala Gly Pro Lys Gly Lys Ala Pro Pro Val Pro Ala 
            820                 825                 830         


Pro Ala Arg Glu Ser Gly Asn Arg Ser Ala Arg Pro Leu His Ser Leu 
        835                 840                 845             


Ser Val Leu Ala Phe Asp Gln Glu Arg Leu Glu Arg Lys Ile Leu Ala 
    850                 855                 860                 


Leu Arg Gln Ala Arg Arg Pro Val Pro Pro Glu Val Ala Gln Gln Tyr 
865                 870                 875                 880 


Gln Asp Ile Met Gln Arg Ser Gln Trp Gln Arg Ala Gln Leu Glu Gln 
                885                 890                 895     


Gly Gly Val Gly Ile Arg Arg Glu Tyr Ala Ala Gln Leu Glu Arg Gln 
            900                 905                 910         


Leu Gln Phe Tyr Thr Glu Ala Ala Arg Arg Leu Gly Asn Asp Gly Ser 
        915                 920                 925             


Arg Asp Ala Ala Lys Glu Ala Leu Tyr Arg Arg Asn Leu Val Glu Ser 
    930                 935                 940                 


Glu Leu Gln Arg Leu Arg Arg 
945                 950     


<210>  1650
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC2D1B__Homo_sapiens__XP_011539232

<400>  1650

Met Met Pro Gly Pro Arg Pro Arg Lys Gly Pro Gln Ala Arg Gly Gln 
1               5                   10                  15      


Gly Val Ala Ala Ala Lys Gln Met Gly Leu Phe Met Glu Phe Gly Pro 
            20                  25                  30          


Glu Asp Met Leu Leu Gly Met Asp Glu Ala Glu Asp Asp Glu Asp Leu 
        35                  40                  45              


Glu Ala Glu Leu Leu Ala Leu Thr Gly Glu Ala Gln Thr Thr Gly Lys 
    50                  55                  60                  


Lys Pro Ala Pro Lys Gly Gln Ala Pro Leu Pro Met Ala His Ile Glu 
65                  70                  75                  80  


Lys Leu Ala Ala Asp Cys Met Arg Asp Val Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Glu Gly Leu Glu Glu Asp Ala Glu Leu Leu Thr Glu Leu Gln Glu Val 
            100                 105                 110         


Leu Gly Val Asp Glu Glu Thr Glu Pro Leu Asp Gly Asp Glu Val Ala 
        115                 120                 125             


Asp Pro Gly Gly Ser Glu Glu Glu Asn Gly Leu Glu Asp Thr Glu Pro 
    130                 135                 140                 


Pro Val Gln Thr Ala Val Leu Thr Ala Ser Ala Pro Ala Ala Gln Ala 
145                 150                 155                 160 


Gly Ala Ser Gln Gly Leu His Ala Leu Leu Glu Glu Arg Ile His Asn 
                165                 170                 175     


Tyr Arg Glu Ala Ala Ala Ser Ala Lys Glu Ala Gly Glu Ala Ala Lys 
            180                 185                 190         


Ala Arg Arg Cys Glu Arg Gly Leu Lys Thr Leu Glu Ser Gln Leu Ala 
        195                 200                 205             


Ser Val Arg Arg Gly Arg Lys Ile Asn Glu Asp Glu Ile Pro Pro Pro 
    210                 215                 220                 


Val Ala Leu Gly Lys Arg Pro Leu Ala Pro Gln Glu Pro Ala Asn Arg 
225                 230                 235                 240 


Ser Pro Glu Thr Asp Pro Pro Ala Pro Pro Ala Leu Glu Ser Asp Asn 
                245                 250                 255     


Pro Ser Gln Pro Glu Thr Ser Leu Pro Gly Ile Ser Ala Gln Pro Val 
            260                 265                 270         


Ser Asp Leu Asp Pro Asp Pro Arg Ala Leu Leu Ser Ser Arg Gln Arg 
        275                 280                 285             


Glu Tyr Lys Val Ala Ala Leu Ser Ala Lys Arg Ala Gly Glu Leu Asp 
    290                 295                 300                 


Arg Ala Arg Glu Leu Met Arg Ile Gly Lys Arg Phe Gly Ala Val Leu 
305                 310                 315                 320 


Glu Ala Leu Glu Lys Gly Gln Pro Val Asp Leu Ser Ala Met Pro Pro 
                325                 330                 335     


Ala Pro Glu Asp Leu Lys Pro Gln Gln Ala Ser Gln Ala Pro Thr Ala 
            340                 345                 350         


Pro Ser Val Ile Pro Pro Ala Val Glu Arg Val Gln Pro Val Met Ala 
        355                 360                 365             


Pro Asp Val Pro Ala Thr Pro Val Ala Pro Thr Glu Ser Gln Thr Val 
    370                 375                 380                 


Leu Asp Ala Leu Gln Gln Arg Leu Asn Lys Tyr Arg Glu Ala Gly Ile 
385                 390                 395                 400 


Gln Ala Arg Ser Gly Gly Asp Glu Arg Lys Ala Arg Met His Glu Arg 
                405                 410                 415     


Ile Ala Lys Gln Tyr Gln Asp Ala Ile Arg Ala His Arg Ala Gly Arg 
            420                 425                 430         


Lys Val Asn Phe Ala Glu Leu Pro Val Pro Pro Gly Phe Pro Pro Ile 
        435                 440                 445             


Pro Gly Leu Glu Ser Thr Met Gly Val Glu Glu Asp Ala Val Ala Ala 
    450                 455                 460                 


Thr Leu Ala Ala Ala Glu Lys Leu Ala Ser Ala Glu Asp Ser Ala Pro 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Asp Glu Pro Pro Gly His Leu Gln Gly Glu Pro 
                485                 490                 495     


Pro Ala Gln Ala Pro Val Ala Lys Lys Pro Ala Arg Pro Thr Val Pro 
            500                 505                 510         


Ser Ser Gln Arg Leu Pro Glu Pro Arg Ala Ser Ser Ser Lys Glu Ser 
        515                 520                 525             


Pro Ser Pro Ser Val Arg Glu Gln Leu Ala Leu Leu Glu Ala Arg Lys 
    530                 535                 540                 


Leu Gln Tyr Gln Arg Ala Ala Leu Gln Ala Lys Arg Ser Gln Asp Leu 
545                 550                 555                 560 


Glu Gln Ala Lys Ala Tyr Leu Arg Val Ala Lys Trp Leu Glu Ala Gln 
                565                 570                 575     


Ile Ile Gln Ala Arg Ser Gly Arg Pro Val Asp Leu Ser Lys Gly Pro 
            580                 585                 590         


Cys Asp Leu Gly Arg Cys Leu Arg Pro 
        595                 600     


<210>  1651
<211>  1620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC2D2A__Homo_sapiens__NP_001073991

<400>  1651

Met Asn Pro Arg Glu Glu Lys Val Lys Ile Ile Thr Glu Glu Phe Ile 
1               5                   10                  15      


Glu Asn Asp Glu Asp Ala Asp Met Gly Arg Gln Asn Lys Asn Ser Lys 
            20                  25                  30          


Val Arg Arg Gln Pro Arg Lys Lys Gln Pro Pro Thr Ala Val Pro Lys 
        35                  40                  45              


Glu Met Val Ser Glu Lys Ser His Leu Gly Asn Pro Gln Glu Pro Val 
    50                  55                  60                  


Gln Glu Glu Pro Lys Thr Arg Leu Leu Ser Met Thr Val Arg Arg Gly 
65                  70                  75                  80  


Pro Arg Ser Leu Pro Pro Ile Pro Ser Thr Ser Arg Thr Gly Phe Ala 
                85                  90                  95      


Glu Phe Ser Met Arg Gly Arg Met Arg Glu Lys Leu Gln Ala Ala Arg 
            100                 105                 110         


Ser Lys Ala Glu Ser Ala Leu Leu Gln Glu Ile Pro Thr Pro Arg Pro 
        115                 120                 125             


Arg Arg Leu Arg Ser Pro Ser Lys Lys Glu Leu Glu Thr Glu Phe Gly 
    130                 135                 140                 


Thr Glu Pro Gly Lys Glu Val Glu Arg Thr Gln Gln Glu Val Asp Ser 
145                 150                 155                 160 


Gln Ser Tyr Ser Arg Val Lys Phe His Asp Ser Ala Arg Lys Ile Lys 
                165                 170                 175     


Pro Lys Pro Gln Val Pro Pro Gly Phe Pro Ser Ala Glu Glu Ala Tyr 
            180                 185                 190         


Asn Phe Phe Thr Phe Asn Phe Asp Pro Glu Pro Glu Gly Ser Glu Glu 
        195                 200                 205             


Lys Pro Lys Ala Arg His Arg Ala Gly Thr Asn Gln Glu Glu Glu Glu 
    210                 215                 220                 


Gly Glu Glu Glu Glu Pro Pro Ala Gln Gly Gly Gly Lys Glu Met Asp 
225                 230                 235                 240 


Glu Glu Glu Leu Leu Asn Gly Asp Asp Ala Glu Asp Phe Leu Leu Gly 
                245                 250                 255     


Leu Asp His Val Ala Asp Asp Phe Val Ala Val Arg Pro Ala Asp Tyr 
            260                 265                 270         


Glu Ser Ile His Asp Arg Leu Gln Met Glu Arg Glu Met Leu Phe Ile 
        275                 280                 285             


Pro Ser Arg Gln Thr Val Pro Thr Tyr Lys Lys Leu Pro Glu Asn Val 
    290                 295                 300                 


Gln Pro Arg Phe Leu Glu Asp Glu Gly Leu Tyr Thr Gly Val Arg Pro 
305                 310                 315                 320 


Glu Val Ala Arg Thr Asn Gln Asn Ile Met Glu Asn Arg Leu Leu Met 
                325                 330                 335     


Gln Asp Pro Glu Arg Arg Trp Phe Gly Asp Asp Gly Arg Ile Leu Ala 
            340                 345                 350         


Leu Pro Asn Pro Ile Lys Pro Phe Pro Ser Arg Pro Pro Val Leu Thr 
        355                 360                 365             


Gln Glu Gln Ser Ile Lys Ala Glu Leu Glu Thr Leu Tyr Lys Lys Ala 
    370                 375                 380                 


Val Lys Tyr Val His Ser Ser Gln His Val Ile Arg Ser Gly Asp Pro 
385                 390                 395                 400 


Pro Gly Asn Phe Gln Leu Asp Ile Asp Ile Ser Gly Leu Ile Phe Thr 
                405                 410                 415     


His His Pro Cys Phe Ser Arg Glu His Val Leu Ala Ala Lys Leu Ala 
            420                 425                 430         


Gln Leu Tyr Asp Gln Tyr Leu Ala Arg His Gln Arg Asn Lys Ala Lys 
        435                 440                 445             


Phe Leu Thr Asp Lys Leu Gln Ala Leu Arg Asn Ala Val Gln Thr Gly 
    450                 455                 460                 


Leu Asp Pro Glu Lys Pro His Gln Ser Leu Asp Thr Ile Gln Lys Thr 
465                 470                 475                 480 


Ile Asn Glu Tyr Lys Ser Glu Ile Arg Gln Thr Arg Lys Phe Arg Asp 
                485                 490                 495     


Ala Glu Gln Glu Lys Asp Arg Thr Leu Leu Lys Thr Ile Ile Lys Val 
            500                 505                 510         


Trp Lys Glu Met Lys Ser Leu Arg Glu Phe Gln Arg Phe Thr Asn Thr 
        515                 520                 525             


Pro Leu Lys Leu Val Leu Arg Lys Glu Lys Ala Asp Gln Lys Ala Asp 
    530                 535                 540                 


Glu Glu Ala Tyr Glu Ala Glu Ile Gln Ala Glu Ile Ser Glu Leu Leu 
545                 550                 555                 560 


Glu Glu His Thr Glu Glu Tyr Ala Gln Lys Met Glu Glu Tyr Arg Thr 
                565                 570                 575     


Ser Leu Gln Gln Trp Lys Ala Trp Arg Lys Val Gln Arg Ala Lys Lys 
            580                 585                 590         


Lys Lys Arg Lys Gln Ala Ala Glu Glu His Pro Gly Asp Glu Ile Ala 
        595                 600                 605             


Glu Pro Tyr Pro Glu Glu Asp Leu Val Lys Pro Ser Pro Pro Glu Pro 
    610                 615                 620                 


Thr Asp Arg Ala Val Ile Glu Gln Glu Val Arg Glu Arg Ala Ala Gln 
625                 630                 635                 640 


Ser Arg Arg Arg Pro Trp Glu Pro Thr Leu Val Pro Glu Leu Ser Leu 
                645                 650                 655     


Ala Gly Ser Val Thr Pro Asn Asp Gln Cys Pro Arg Ala Glu Val Ser 
            660                 665                 670         


Arg Arg Glu Asp Val Lys Lys Arg Ser Val Tyr Leu Lys Val Leu Phe 
        675                 680                 685             


Asn Asn Lys Glu Val Ser Arg Thr Val Ser Arg Pro Leu Gly Ala Asp 
    690                 695                 700                 


Phe Arg Val His Phe Gly Gln Ile Phe Asn Leu Gln Ile Val Asn Trp 
705                 710                 715                 720 


Pro Glu Ser Leu Thr Leu Gln Val Tyr Glu Thr Val Gly His Ser Ser 
                725                 730                 735     


Pro Thr Leu Leu Ala Glu Val Phe Leu Pro Ile Pro Glu Thr Thr Val 
            740                 745                 750         


Val Thr Gly Arg Ala Pro Thr Glu Glu Val Glu Phe Ser Ser Asn Gln 
        755                 760                 765             


His Val Thr Leu Asp His Glu Gly Val Gly Ser Gly Val Pro Phe Ser 
    770                 775                 780                 


Phe Glu Ala Asp Gly Ser Asn Gln Leu Thr Leu Met Thr Ser Gly Lys 
785                 790                 795                 800 


Val Ser His Ser Val Ala Trp Ala Ile Gly Glu Asn Gly Ile Pro Leu 
                805                 810                 815     


Ile Pro Pro Leu Ser Gln Gln Asn Ile Gly Phe Arg Ser Ala Leu Lys 
            820                 825                 830         


Lys Ala Asp Ala Ile Ser Ser Ile Gly Thr Ser Gly Leu Thr Asp Met 
        835                 840                 845             


Lys Lys Leu Ala Lys Trp Ala Ala Glu Ser Lys Leu Asp Pro Asn Asp 
    850                 855                 860                 


Pro Asn Asn Ala Pro Leu Met Gln Leu Ile Ser Val Ala Thr Ser Gly 
865                 870                 875                 880 


Glu Ser Tyr Val Pro Asp Phe Phe Arg Leu Glu Gln Leu Gln Gln Glu 
                885                 890                 895     


Phe Asn Phe Val Ser Asp Gln Glu Leu Asn Arg Ser Lys Arg Phe Arg 
            900                 905                 910         


Leu Leu His Leu Arg Ser Gln Glu Val Pro Glu Phe Arg Asn Tyr Lys 
        915                 920                 925             


Gln Val Pro Val Tyr Asp Arg Glu Ile Met Glu Lys Val Phe Gln Asp 
    930                 935                 940                 


Tyr Glu Lys Arg Leu Arg Asp Arg Asn Val Ile Glu Thr Lys Glu His 
945                 950                 955                 960 


Ile Asp Thr His Arg Ala Ile Val Ala Lys Tyr Leu Gln Gln Val Arg 
                965                 970                 975     


Glu Ser Val Ile Asn Arg Phe Leu Ile Ala Lys Gln Tyr Phe Leu Leu 
            980                 985                 990         


Ala Asp Met Ile Val Glu Glu Glu  Val Pro Asn Ile Ser  Ile Leu Gly 
        995                 1000                 1005             


Leu Ser  Leu Phe Lys Leu Ala  Glu Gln Lys Arg Pro  Leu Arg Pro 
    1010                 1015                 1020             


Arg Arg  Lys Gly Arg Lys Lys  Val Thr Ala Gln Asn  Leu Ser Asp 
    1025                 1030                 1035             


Gly Asp  Ile Lys Leu Leu Val  Asn Ile Val Arg Ala  Tyr Asp Ile 
    1040                 1045                 1050             


Pro Val  Arg Lys Pro Ala Val  Ser Lys Phe Gln Gln  Pro Ser Arg 
    1055                 1060                 1065             


Ser Ser  Arg Met Phe Ser Glu  Lys His Ala Ala Ser  Pro Ser Thr 
    1070                 1075                 1080             


Tyr Ser  Pro Thr His Asn Ala  Asp Tyr Pro Leu Gly  Gln Val Leu 
    1085                 1090                 1095             


Val Arg  Pro Phe Val Glu Val  Ser Phe Gln Arg Thr  Val Cys His 
    1100                 1105                 1110             


Thr Thr  Thr Ala Glu Gly Pro  Asn Pro Ser Trp Asn  Glu Glu Leu 
    1115                 1120                 1125             


Glu Leu  Pro Phe Arg Ala Pro  Asn Gly Asp Tyr Ser  Thr Ala Ser 
    1130                 1135                 1140             


Leu Gln  Ser Val Lys Asp Val  Val Phe Ile Asn Ile  Phe Asp Glu 
    1145                 1150                 1155             


Val Leu  His Asp Val Leu Glu  Asp Asp Arg Glu Arg  Gly Ser Gly 
    1160                 1165                 1170             


Ile His  Thr Arg Ile Glu Arg  His Trp Leu Gly Cys  Val Lys Met 
    1175                 1180                 1185             


Pro Phe  Ser Thr Ile Tyr Phe  Gln Ala Arg Ile Asp  Gly Thr Phe 
    1190                 1195                 1200             


Lys Ile  Asp Ile Pro Pro Val  Leu Leu Gly Tyr Ser  Lys Glu Arg 
    1205                 1210                 1215             


Asn Met  Ile Leu Glu Arg Gly  Phe Asp Ser Val Arg  Ser Leu Ser 
    1220                 1225                 1230             


Glu Gly  Ser Tyr Ile Thr Leu  Phe Ile Thr Ile Glu  Pro Gln Leu 
    1235                 1240                 1245             


Val Pro  Gly Glu Ser Ile Arg  Glu Lys Phe Glu Ser  Gln Glu Asp 
    1250                 1255                 1260             


Glu Lys  Leu Leu Gln Ala Thr  Glu Lys Phe Gln Ala  Glu Cys Ala 
    1265                 1270                 1275             


Leu Lys  Phe Pro Asn Arg Gln  Cys Leu Thr Thr Val  Ile Asp Ile 
    1280                 1285                 1290             


Ser Gly  Lys Thr Val Phe Ile  Thr Arg Tyr Leu Lys  Pro Leu Asn 
    1295                 1300                 1305             


Pro Pro  Gln Glu Leu Leu Asn  Val Tyr Pro Asn Asn  Leu Gln Ala 
    1310                 1315                 1320             


Thr Ala  Glu Leu Val Ala Arg  Tyr Val Ser Leu Ile  Pro Phe Leu 
    1325                 1330                 1335             


Pro Asp  Thr Val Ser Phe Gly  Gly Ile Cys Asp Leu  Trp Ser Thr 
    1340                 1345                 1350             


Ser Asp  Gln Phe Leu Asp Leu  Leu Ala Gly Asp Glu  Glu Glu His 
    1355                 1360                 1365             


Ala Val  Leu Leu Cys Asn Tyr  Phe Leu Ser Leu Gly  Lys Lys Ala 
    1370                 1375                 1380             


Trp Leu  Leu Met Gly Asn Ala  Ile Pro Glu Gly Pro  Thr Ala Tyr 
    1385                 1390                 1395             


Val Leu  Thr Trp Glu Gln Gly  Arg Tyr Leu Ile Trp  Asn Pro Cys 
    1400                 1405                 1410             


Ser Gly  His Phe Tyr Gly Gln  Phe Asp Thr Phe Cys  Pro Leu Lys 
    1415                 1420                 1425             


Asn Val  Gly Cys Leu Ile Gly  Pro Asp Asn Ile Trp  Phe Asn Ile 
    1430                 1435                 1440             


Gln Arg  Tyr Glu Ser Pro Leu  Arg Ile Asn Phe Asp  Val Thr Arg 
    1445                 1450                 1455             


Pro Lys  Leu Trp Lys Ser Phe  Phe Ser Arg Ser Leu  Pro Tyr Pro 
    1460                 1465                 1470             


Gly Leu  Ser Ser Val Gln Pro  Glu Glu Leu Ile Tyr  Gln Arg Ser 
    1475                 1480                 1485             


Asp Lys  Ala Ala Ala Ala Glu  Leu Gln Asp Arg Ile  Glu Lys Ile 
    1490                 1495                 1500             


Leu Lys  Glu Lys Ile Met Asp  Trp Arg Pro Arg His  Leu Thr Arg 
    1505                 1510                 1515             


Trp Asn  Arg Tyr Cys Thr Ser  Thr Leu Arg His Phe  Leu Pro Leu 
    1520                 1525                 1530             


Leu Glu  Lys Ser Gln Gly Glu  Asp Val Glu Asp Asp  His Arg Ala 
    1535                 1540                 1545             


Glu Leu  Leu Lys Gln Leu Gly  Asp Tyr Arg Phe Ser  Gly Phe Pro 
    1550                 1555                 1560             


Leu His  Met Pro Tyr Ser Glu  Val Lys Pro Leu Ile  Asp Ala Val 
    1565                 1570                 1575             


Tyr Ser  Thr Gly Val His Asn  Ile Asp Val Pro Asn  Val Glu Phe 
    1580                 1585                 1590             


Ala Leu  Ala Val Tyr Ile His  Pro Tyr Pro Lys Asn  Val Leu Ser 
    1595                 1600                 1605             


Val Trp  Ile Tyr Val Ala Ser  Leu Ile Arg Asn Arg  
    1610                 1615                 1620 


<210>  1652
<211>  1135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCAR1__Homo_sapiens__NP_001269889

<400>  1652

Met Ala Gln Phe Gly Gly Gln Lys Asn Pro Pro Trp Ala Thr Gln Phe 
1               5                   10                  15      


Thr Ala Thr Ala Val Ser Gln Pro Ala Ala Leu Gly Val Gln Gln Pro 
            20                  25                  30          


Ser Leu Leu Gly Ala Ser Pro Thr Ile Tyr Thr Gln Gln Thr Ala Leu 
        35                  40                  45              


Ala Ala Ala Gly Leu Thr Thr Gln Thr Pro Ala Asn Tyr Gln Leu Thr 
    50                  55                  60                  


Gln Thr Ala Ala Leu Gln Gln Gln Ala Ala Ala Ala Ala Ala Ala Leu 
65                  70                  75                  80  


Gln Gln Leu Gln Gln Pro Gln Gln Thr Leu Leu Thr Gln Pro Ala Val 
                85                  90                  95      


Ala Leu Pro Thr Ser Leu Ser Leu Ser Thr Pro Gln Pro Thr Ala Gln 
            100                 105                 110         


Ile Thr Val Ser Tyr Pro Thr Pro Arg Ser Ser Gln Gln Gln Thr Gln 
        115                 120                 125             


Pro Gln Lys Gln Arg Val Phe Thr Gly Val Val Thr Lys Leu His Asp 
    130                 135                 140                 


Thr Phe Gly Phe Val Asp Glu Asp Val Phe Phe Gln Leu Ser Ala Val 
145                 150                 155                 160 


Lys Gly Lys Thr Pro Gln Val Gly Asp Arg Val Leu Val Glu Ala Thr 
                165                 170                 175     


Tyr Asn Pro Asn Met Pro Phe Lys Trp Asn Ala Gln Arg Ile Gln Thr 
            180                 185                 190         


Leu Pro Asn Gln Asn Gln Ser Gln Thr Gln Pro Leu Leu Lys Thr Pro 
        195                 200                 205             


Pro Ala Val Leu Gln Pro Ile Ala Pro Gln Thr Thr Phe Gly Val Gln 
    210                 215                 220                 


Thr Gln Pro Gln Pro Gln Ser Leu Leu Gln Ala Gln Ile Ser Ala Ala 
225                 230                 235                 240 


Ser Ile Thr Pro Leu Leu Gln Thr Gln Pro Gln Pro Leu Leu Gln Gln 
                245                 250                 255     


Pro Gln Gln Lys Ala Gly Leu Leu Gln Pro Pro Val Arg Ile Val Ser 
            260                 265                 270         


Gln Pro Gln Pro Ala Arg Arg Leu Asp Pro Pro Ser Arg Phe Ser Gly 
        275                 280                 285             


Arg Asn Asp Arg Gly Asp Gln Val Pro Asn Arg Lys Asp Asp Arg Ser 
    290                 295                 300                 


Arg Glu Arg Glu Arg Glu Arg Arg Arg Ser Arg Glu Arg Ser Pro Gln 
305                 310                 315                 320 


Arg Lys Arg Ser Arg Glu Arg Ser Pro Arg Arg Glu Arg Glu Arg Ser 
                325                 330                 335     


Pro Arg Arg Val Arg Arg Val Val Pro Arg Tyr Thr Val Gln Phe Ser 
            340                 345                 350         


Lys Phe Ser Leu Asp Cys Pro Ser Cys Asp Met Met Glu Leu Arg Arg 
        355                 360                 365             


Arg Tyr Gln Asn Leu Tyr Ile Pro Ser Asp Phe Phe Asp Ala Gln Phe 
    370                 375                 380                 


Thr Trp Val Asp Ala Phe Pro Leu Ser Arg Pro Phe Gln Leu Gly Asn 
385                 390                 395                 400 


Tyr Cys Asn Phe Tyr Val Met His Arg Glu Val Glu Ser Leu Glu Lys 
                405                 410                 415     


Asn Met Ala Ile Leu Asp Pro Pro Asp Ala Asp His Leu Tyr Ser Ala 
            420                 425                 430         


Lys Val Met Leu Met Ala Ser Pro Ser Met Glu Asp Leu Tyr His Lys 
        435                 440                 445             


Ser Cys Ala Leu Ala Glu Asp Pro Gln Glu Leu Arg Asp Gly Phe Gln 
    450                 455                 460                 


His Pro Ala Arg Leu Val Lys Phe Leu Val Gly Met Lys Gly Lys Asp 
465                 470                 475                 480 


Glu Ala Met Ala Ile Gly Gly His Trp Ser Pro Ser Leu Asp Gly Pro 
                485                 490                 495     


Asp Pro Glu Lys Asp Pro Ser Val Leu Ile Lys Thr Ala Ile Arg Cys 
            500                 505                 510         


Cys Lys Ala Leu Thr Gly Ile Asp Leu Ser Val Cys Thr Gln Trp Tyr 
        515                 520                 525             


Arg Phe Ala Glu Ile Arg Tyr His Arg Pro Glu Glu Thr His Lys Gly 
    530                 535                 540                 


Arg Thr Val Pro Ala His Val Glu Thr Val Val Leu Phe Phe Pro Asp 
545                 550                 555                 560 


Val Trp His Cys Leu Pro Thr Arg Ser Glu Trp Glu Thr Leu Ser Arg 
                565                 570                 575     


Gly Tyr Lys Gln Gln Leu Val Glu Lys Leu Gln Gly Glu Arg Lys Glu 
            580                 585                 590         


Ala Asp Gly Glu Gln Asp Glu Glu Glu Lys Asp Asp Gly Glu Ala Lys 
        595                 600                 605             


Glu Ile Ser Thr Pro Thr His Trp Ser Lys Leu Asp Pro Lys Thr Met 
    610                 615                 620                 


Lys Val Asn Asp Leu Arg Lys Glu Leu Glu Ser Arg Ala Leu Ser Ser 
625                 630                 635                 640 


Lys Gly Leu Lys Ser Gln Leu Ile Ala Arg Leu Thr Lys Gln Leu Lys 
                645                 650                 655     


Val Glu Glu Gln Lys Glu Glu Gln Lys Glu Leu Glu Lys Ser Glu Lys 
            660                 665                 670         


Glu Glu Asp Glu Asp Asp Asp Arg Lys Ser Glu Asp Asp Lys Glu Glu 
        675                 680                 685             


Glu Glu Arg Lys Arg Gln Glu Glu Ile Glu Arg Gln Arg Arg Glu Arg 
    690                 695                 700                 


Arg Tyr Ile Leu Pro Asp Glu Pro Ala Ile Ile Val His Pro Asn Trp 
705                 710                 715                 720 


Ala Ala Lys Ser Gly Lys Phe Asp Cys Ser Ile Met Ser Leu Ser Val 
                725                 730                 735     


Leu Leu Asp Tyr Arg Leu Glu Asp Asn Lys Glu His Ser Phe Glu Val 
            740                 745                 750         


Ser Leu Phe Ala Glu Leu Phe Asn Glu Met Leu Gln Arg Asp Phe Gly 
        755                 760                 765             


Val Arg Ile Tyr Lys Ser Leu Leu Ser Leu Pro Glu Lys Glu Asp Lys 
    770                 775                 780                 


Lys Glu Lys Asp Lys Lys Ser Lys Lys Asp Glu Arg Lys Asp Lys Lys 
785                 790                 795                 800 


Glu Glu Arg Asp Asp Glu Thr Asp Glu Pro Lys Pro Lys Arg Arg Lys 
                805                 810                 815     


Ser Gly Asp Asp Lys Asp Lys Lys Glu Asp Arg Asp Glu Arg Lys Lys 
            820                 825                 830         


Glu Asp Lys Arg Lys Asp Asp Ser Lys Asp Asp Asp Glu Thr Glu Glu 
        835                 840                 845             


Asp Asn Asn Gln Asp Glu Tyr Asp Pro Met Glu Ala Glu Glu Ala Glu 
    850                 855                 860                 


Asp Glu Glu Asp Asp Arg Asp Glu Glu Glu Met Thr Lys Arg Asp Asp 
865                 870                 875                 880 


Lys Arg Asp Ile Asn Arg Tyr Cys Lys Glu Arg Pro Ser Lys Asp Lys 
                885                 890                 895     


Glu Lys Glu Lys Thr Gln Met Ile Thr Ile Asn Arg Asp Leu Leu Met 
            900                 905                 910         


Ala Phe Val Tyr Phe Asp Gln Ser His Cys Gly Tyr Leu Leu Glu Lys 
        915                 920                 925             


Asp Leu Glu Glu Ile Leu Tyr Thr Leu Gly Leu His Leu Ser Arg Ala 
    930                 935                 940                 


Gln Val Lys Lys Leu Leu Asn Lys Val Val Leu Arg Glu Ser Cys Phe 
945                 950                 955                 960 


Tyr Arg Lys Leu Thr Asp Thr Ser Lys Asp Glu Glu Asn His Glu Glu 
                965                 970                 975     


Ser Glu Ser Leu Gln Glu Asp Met Leu Gly Asn Arg Leu Leu Leu Pro 
            980                 985                 990         


Thr Pro Thr Val Lys Gln Glu Ser  Lys Asp Val Glu Glu  Asn Val Gly 
        995                 1000                 1005             


Leu Ile  Val Tyr Asn Gly Ala  Met Val Asp Val Gly  Ser Leu Leu 
    1010                 1015                 1020             


Gln Lys  Leu Glu Lys Ser Glu  Lys Val Arg Ala Glu  Val Glu Gln 
    1025                 1030                 1035             


Lys Leu  Gln Leu Leu Glu Glu  Lys Thr Asp Glu Asp  Glu Lys Thr 
    1040                 1045                 1050             


Ile Leu  Asn Leu Glu Asn Ser  Asn Lys Ser Leu Ser  Gly Glu Leu 
    1055                 1060                 1065             


Arg Glu  Val Lys Lys Asp Leu  Ser Gln Leu Gln Glu  Asn Leu Lys 
    1070                 1075                 1080             


Ile Ser  Glu Asn Met Asn Leu  Gln Phe Glu Asn Gln  Met Asn Lys 
    1085                 1090                 1095             


Thr Ile  Arg Asn Leu Ser Thr  Val Met Asp Glu Ile  His Thr Val 
    1100                 1105                 1110             


Leu Lys  Lys Asp Asn Val Lys  Asn Glu Asp Lys Asp  Gln Lys Ser 
    1115                 1120                 1125             


Lys Glu  Asn Gly Ala Ser Val  
    1130                 1135 


<210>  1653
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCAR2__Homo_sapiens__NP_066997

<400>  1653

Met Ser Gln Phe Lys Arg Gln Arg Ile Asn Pro Leu Pro Gly Gly Arg 
1               5                   10                  15      


Asn Phe Ser Gly Thr Ala Ser Thr Ser Leu Leu Gly Pro Pro Pro Gly 
            20                  25                  30          


Leu Leu Thr Pro Pro Val Ala Thr Glu Leu Ser Gln Asn Ala Arg His 
        35                  40                  45              


Leu Gln Gly Gly Glu Lys Gln Arg Val Phe Thr Gly Ile Val Thr Ser 
    50                  55                  60                  


Leu His Asp Tyr Phe Gly Val Val Asp Glu Glu Val Phe Phe Gln Leu 
65                  70                  75                  80  


Ser Val Val Lys Gly Arg Leu Pro Gln Leu Gly Glu Lys Val Leu Val 
                85                  90                  95      


Lys Ala Ala Tyr Asn Pro Gly Gln Ala Val Pro Trp Asn Ala Val Lys 
            100                 105                 110         


Val Gln Thr Leu Ser Asn Gln Pro Leu Leu Lys Ser Pro Ala Pro Pro 
        115                 120                 125             


Leu Leu His Val Ala Ala Leu Gly Gln Lys Gln Gly Ile Leu Gly Ala 
    130                 135                 140                 


Gln Pro Gln Leu Ile Phe Gln Pro His Arg Ile Pro Pro Leu Phe Pro 
145                 150                 155                 160 


Gln Lys Pro Leu Ser Leu Phe Gln Thr Ser His Thr Leu His Leu Ser 
                165                 170                 175     


His Leu Asn Arg Phe Pro Ala Arg Gly Pro His Gly Arg Leu Asp Gln 
            180                 185                 190         


Gly Arg Ser Asp Asp Tyr Asp Ser Lys Lys Arg Lys Gln Arg Ala Gly 
        195                 200                 205             


Gly Glu Pro Trp Gly Ala Lys Lys Pro Arg His Asp Leu Pro Pro Tyr 
    210                 215                 220                 


Arg Val His Leu Thr Pro Tyr Thr Val Asp Ser Pro Ile Cys Asp Phe 
225                 230                 235                 240 


Leu Glu Leu Gln Arg Arg Tyr Arg Ser Leu Leu Val Pro Ser Asp Phe 
                245                 250                 255     


Leu Ser Val His Leu Ser Trp Leu Ser Ala Phe Pro Leu Ser Gln Pro 
            260                 265                 270         


Phe Ser Leu His His Pro Ser Arg Ile Gln Val Ser Ser Glu Lys Glu 
        275                 280                 285             


Ala Ala Pro Asp Ala Gly Ala Glu Pro Ile Thr Ala Asp Ser Asp Pro 
    290                 295                 300                 


Ala Tyr Ser Ser Lys Val Leu Leu Leu Ser Ser Pro Gly Leu Glu Glu 
305                 310                 315                 320 


Leu Tyr Arg Cys Cys Met Leu Phe Val Asp Asp Met Ala Glu Pro Arg 
                325                 330                 335     


Glu Thr Pro Glu His Pro Leu Lys Gln Ile Lys Phe Leu Leu Gly Arg 
            340                 345                 350         


Lys Glu Glu Glu Ala Val Leu Val Gly Gly Glu Trp Ser Pro Ser Leu 
        355                 360                 365             


Asp Gly Leu Asp Pro Gln Ala Asp Pro Gln Val Leu Val Arg Thr Ala 
    370                 375                 380                 


Ile Arg Cys Ala Gln Ala Gln Thr Gly Ile Asp Leu Ser Gly Cys Thr 
385                 390                 395                 400 


Lys Trp Trp Arg Phe Ala Glu Phe Gln Tyr Leu Gln Pro Gly Pro Pro 
                405                 410                 415     


Arg Arg Leu Gln Thr Val Val Val Tyr Leu Pro Asp Val Trp Thr Ile 
            420                 425                 430         


Met Pro Thr Leu Glu Glu Trp Glu Ala Leu Cys Gln Gln Lys Ala Ala 
        435                 440                 445             


Glu Ala Ala Pro Pro Thr Gln Glu Ala Gln Gly Glu Thr Glu Pro Thr 
    450                 455                 460                 


Glu Gln Ala Pro Asp Ala Leu Glu Gln Ala Ala Asp Thr Ser Arg Arg 
465                 470                 475                 480 


Asn Ala Glu Thr Pro Glu Ala Thr Thr Gln Gln Glu Thr Asp Thr Asp 
                485                 490                 495     


Leu Pro Glu Ala Pro Pro Pro Pro Leu Glu Pro Ala Val Ile Ala Arg 
            500                 505                 510         


Pro Gly Cys Val Asn Leu Ser Leu His Gly Ile Val Glu Asp Arg Arg 
        515                 520                 525             


Pro Lys Glu Arg Ile Ser Phe Glu Val Met Val Leu Ala Glu Leu Phe 
    530                 535                 540                 


Leu Glu Met Leu Gln Arg Asp Phe Gly Tyr Arg Val Tyr Lys Met Leu 
545                 550                 555                 560 


Leu Ser Leu Pro Glu Lys Val Val Ser Pro Pro Glu Pro Glu Lys Glu 
                565                 570                 575     


Glu Ala Ala Lys Glu Glu Ala Thr Lys Glu Glu Glu Ala Ile Lys Glu 
            580                 585                 590         


Glu Val Val Lys Glu Pro Lys Asp Glu Ala Gln Asn Glu Gly Pro Ala 
        595                 600                 605             


Thr Glu Ser Glu Ala Pro Leu Lys Glu Asp Gly Leu Leu Pro Lys Pro 
    610                 615                 620                 


Leu Ser Ser Gly Gly Glu Glu Glu Glu Lys Pro Arg Gly Glu Ala Ser 
625                 630                 635                 640 


Glu Asp Leu Cys Glu Met Ala Leu Asp Pro Glu Leu Leu Leu Leu Arg 
                645                 650                 655     


Asp Asp Gly Glu Glu Glu Phe Ala Gly Ala Lys Leu Glu Asp Ser Glu 
            660                 665                 670         


Val Arg Ser Val Ala Ser Asn Gln Ser Glu Met Glu Phe Ser Ser Leu 
        675                 680                 685             


Gln Asp Met Pro Lys Glu Leu Asp Pro Ser Ala Val Leu Pro Leu Asp 
    690                 695                 700                 


Cys Leu Leu Ala Phe Val Phe Phe Asp Ala Asn Trp Cys Gly Tyr Leu 
705                 710                 715                 720 


His Arg Arg Asp Leu Glu Arg Ile Leu Leu Thr Leu Gly Ile Arg Leu 
                725                 730                 735     


Ser Ala Glu Gln Ala Lys Gln Leu Val Ser Arg Val Val Thr Gln Asn 
            740                 745                 750         


Ile Cys Gln Tyr Arg Ser Leu Gln Tyr Ser Arg Gln Glu Gly Leu Asp 
        755                 760                 765             


Gly Gly Leu Pro Glu Glu Val Leu Phe Gly Asn Leu Asp Leu Leu Pro 
    770                 775                 780                 


Pro Pro Gly Lys Ser Thr Lys Pro Gly Ala Ala Pro Thr Glu His Lys 
785                 790                 795                 800 


Ala Leu Val Ser His Asn Gly Ser Leu Ile Asn Val Gly Ser Leu Leu 
                805                 810                 815     


Gln Arg Ala Glu Gln Gln Asp Ser Gly Arg Leu Tyr Leu Glu Asn Lys 
            820                 825                 830         


Ile His Thr Leu Glu Leu Lys Leu Glu Glu Ser His Asn Arg Phe Ser 
        835                 840                 845             


Ala Thr Glu Val Thr Asn Lys Thr Leu Ala Ala Glu Met Gln Glu Leu 
    850                 855                 860                 


Arg Val Arg Leu Ala Glu Ala Glu Glu Thr Ala Arg Thr Ala Glu Arg 
865                 870                 875                 880 


Gln Lys Ser Gln Leu Gln Arg Leu Leu Gln Glu Leu Arg Arg Arg Leu 
                885                 890                 895     


Thr Pro Leu Gln Leu Glu Ile Gln Arg Val Val Glu Lys Ala Asp Ser 
            900                 905                 910         


Trp Val Glu Lys Glu Glu Pro Ala Pro Ser Asn 
        915                 920             


<210>  1654
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCBE1__Homo_sapiens__NP_597716

<400>  1654

Met Val Pro Pro Pro Pro Ser Arg Gly Gly Ala Ala Arg Gly Gln Leu 
1               5                   10                  15      


Gly Arg Ser Leu Gly Pro Leu Leu Leu Leu Leu Ala Leu Gly His Thr 
            20                  25                  30          


Trp Thr Tyr Arg Glu Glu Pro Glu Asp Gly Asp Arg Glu Ile Cys Ser 
        35                  40                  45              


Glu Ser Lys Ile Ala Thr Thr Lys Tyr Pro Cys Leu Lys Ser Ser Gly 
    50                  55                  60                  


Glu Leu Thr Thr Cys Tyr Arg Lys Lys Cys Cys Lys Gly Tyr Lys Phe 
65                  70                  75                  80  


Val Leu Gly Gln Cys Ile Pro Glu Asp Tyr Asp Val Cys Ala Glu Ala 
                85                  90                  95      


Pro Cys Glu Gln Gln Cys Thr Asp Asn Phe Gly Arg Val Leu Cys Thr 
            100                 105                 110         


Cys Tyr Pro Gly Tyr Arg Tyr Asp Arg Glu Arg His Arg Lys Arg Glu 
        115                 120                 125             


Lys Pro Tyr Cys Leu Asp Ile Asp Glu Cys Ala Ser Ser Asn Gly Thr 
    130                 135                 140                 


Leu Cys Ala His Ile Cys Ile Asn Thr Leu Gly Ser Tyr Arg Cys Glu 
145                 150                 155                 160 


Cys Arg Glu Gly Tyr Ile Arg Glu Asp Asp Gly Lys Thr Cys Thr Arg 
                165                 170                 175     


Gly Asp Lys Tyr Pro Asn Asp Thr Gly His Glu Lys Ser Glu Asn Met 
            180                 185                 190         


Val Lys Ala Gly Thr Cys Cys Ala Thr Cys Lys Glu Phe Tyr Gln Met 
        195                 200                 205             


Lys Gln Thr Val Leu Gln Leu Lys Gln Lys Ile Ala Leu Leu Pro Asn 
    210                 215                 220                 


Asn Ala Ala Asp Leu Gly Lys Tyr Ile Thr Gly Asp Lys Val Leu Ala 
225                 230                 235                 240 


Ser Asn Thr Tyr Leu Pro Gly Pro Pro Gly Leu Pro Gly Gly Gln Gly 
                245                 250                 255     


Pro Pro Gly Ser Pro Gly Pro Lys Gly Ser Pro Gly Phe Pro Gly Met 
            260                 265                 270         


Pro Gly Pro Pro Gly Gln Pro Gly Pro Arg Gly Ser Met Gly Pro Met 
        275                 280                 285             


Gly Pro Ser Pro Asp Leu Ser His Ile Lys Gln Gly Arg Arg Gly Pro 
    290                 295                 300                 


Val Gly Pro Pro Gly Ala Pro Gly Arg Asp Gly Ser Lys Gly Glu Arg 
305                 310                 315                 320 


Gly Ala Pro Gly Pro Arg Gly Ser Pro Gly Pro Pro Gly Ser Phe Asp 
                325                 330                 335     


Phe Leu Leu Leu Met Leu Ala Asp Ile Arg Asn Asp Ile Thr Glu Leu 
            340                 345                 350         


Gln Glu Lys Val Phe Gly His Arg Thr His Ser Ser Ala Glu Glu Phe 
        355                 360                 365             


Pro Leu Pro Gln Glu Phe Pro Ser Tyr Pro Glu Ala Met Asp Leu Gly 
    370                 375                 380                 


Ser Gly Asp Asp His Pro Arg Arg Thr Glu Thr Arg Asp Leu Arg Ala 
385                 390                 395                 400 


Pro Arg Asp Phe Tyr Pro 
                405     


<210>  1655
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCBL1__Homo_sapiens__NP_001116144

<400>  1655

Met Ala Lys Gln Leu Gln Ala Arg Arg Leu Asp Gly Ile Asp Tyr Asn 
1               5                   10                  15      


Pro Trp Val Glu Phe Val Lys Leu Ala Ser Glu His Asp Val Val Asn 
            20                  25                  30          


Leu Gly Gln Gly Phe Pro Asp Phe Pro Pro Pro Asp Phe Ala Val Glu 
        35                  40                  45              


Ala Phe Gln His Ala Val Ser Gly Asp Phe Met Leu Asn Gln Tyr Thr 
    50                  55                  60                  


Lys Thr Phe Val Ile Ile Ile Glu Pro Phe Phe Asp Cys Tyr Glu Pro 
65                  70                  75                  80  


Met Thr Met Met Ala Gly Gly Arg Pro Val Phe Val Ser Leu Lys Pro 
                85                  90                  95      


Gly Pro Ile Gln Asn Gly Glu Leu Gly Ser Ser Ser Asn Trp Gln Leu 
            100                 105                 110         


Asp Pro Met Glu Leu Ala Gly Lys Phe Thr Ser Arg Thr Lys Ala Leu 
        115                 120                 125             


Val Leu Asn Thr Pro Asn Asn Pro Leu Gly Lys Val Phe Ser Arg Glu 
    130                 135                 140                 


Glu Leu Glu Leu Val Ala Ser Leu Cys Gln Gln His Asp Val Val Cys 
145                 150                 155                 160 


Ile Thr Asp Glu Val Tyr Gln Trp Met Val Tyr Asp Gly His Gln His 
                165                 170                 175     


Ile Ser Ile Ala Ser Leu Pro Gly Met Trp Glu Arg Thr Leu Thr Ile 
            180                 185                 190         


Gly Ser Ala Gly Lys Thr Phe Ser Ala Thr Gly Trp Lys Val Gly Trp 
        195                 200                 205             


Val Leu Gly Pro Asp His Ile Met Lys His Leu Arg Thr Val His Gln 
    210                 215                 220                 


Asn Ser Val Phe His Cys Pro Thr Gln Ser Gln Ala Ala Val Ala Glu 
225                 230                 235                 240 


Ser Phe Glu Arg Glu Gln Leu Leu Phe Arg Gln Pro Ser Ser Tyr Phe 
                245                 250                 255     


Val Gln Phe Pro Gln Ala Met Gln Arg Cys Arg Asp His Met Ile Arg 
            260                 265                 270         


Ser Leu Gln Ser Val Gly Leu Lys Pro Ile Ile Pro Gln Gly Ser Tyr 
        275                 280                 285             


Phe Leu Ile Thr Asp Ile Ser Asp Phe Lys Arg Lys Met Pro Asp Leu 
    290                 295                 300                 


Pro Gly Ala Val Asp Glu Pro Tyr Asp Arg Arg Phe Val Lys Trp Met 
305                 310                 315                 320 


Ile Lys Asn Lys Gly Leu Val Ala Ile Pro Val Ser Ile Phe Tyr Ser 
                325                 330                 335     


Val Pro His Gln Lys His Phe Asp His Tyr Ile Arg Phe Cys Phe Val 
            340                 345                 350         


Lys Asp Glu Ala Thr Leu Gln Ala Met Asp Glu Lys Leu Arg Lys Trp 
        355                 360                 365             


Lys Val Glu Leu 
    370         


<210>  1656
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC101__Homo_sapiens__NP_612423

<400>  1656

Met Ala Leu Val Ser Ala Asp Ser Arg Ile Ala Glu Leu Leu Thr Glu 
1               5                   10                  15      


Leu His Gln Leu Ile Lys Gln Thr Gln Glu Glu Arg Ser Arg Ser Glu 
            20                  25                  30          


His Asn Leu Val Asn Ile Gln Lys Thr His Glu Arg Met Gln Thr Glu 
        35                  40                  45              


Asn Lys Ile Ser Pro Tyr Tyr Arg Thr Lys Leu Arg Gly Leu Tyr Thr 
    50                  55                  60                  


Thr Ala Lys Ala Asp Ala Glu Ala Glu Cys Asn Ile Leu Arg Lys Ala 
65                  70                  75                  80  


Leu Asp Lys Ile Ala Glu Ile Lys Ser Leu Leu Glu Glu Arg Arg Ile 
                85                  90                  95      


Ala Ala Lys Ile Ala Gly Leu Tyr Asn Asp Ser Glu Pro Pro Arg Lys 
            100                 105                 110         


Thr Met Arg Arg Gly Val Leu Met Thr Leu Leu Gln Gln Ser Ala Met 
        115                 120                 125             


Thr Leu Pro Leu Trp Ile Gly Lys Pro Gly Asp Lys Pro Pro Pro Leu 
    130                 135                 140                 


Cys Gly Ala Ile Pro Ala Ser Gly Asp Tyr Val Ala Arg Pro Gly Asp 
145                 150                 155                 160 


Lys Val Ala Ala Arg Val Lys Ala Val Asp Gly Asp Glu Gln Trp Ile 
                165                 170                 175     


Leu Ala Glu Val Val Ser Tyr Ser His Ala Thr Asn Lys Tyr Glu Val 
            180                 185                 190         


Asp Asp Ile Asp Glu Glu Gly Lys Glu Arg His Thr Leu Ser Arg Arg 
        195                 200                 205             


Arg Val Ile Pro Leu Pro Gln Trp Lys Ala Asn Pro Glu Thr Asp Pro 
    210                 215                 220                 


Glu Ala Leu Phe Gln Lys Glu Gln Leu Val Leu Ala Leu Tyr Pro Gln 
225                 230                 235                 240 


Thr Thr Cys Phe Tyr Arg Ala Leu Ile His Ala Pro Pro Gln Arg Pro 
                245                 250                 255     


Gln Asp Asp Tyr Ser Val Leu Phe Glu Asp Thr Ser Tyr Ala Asp Gly 
            260                 265                 270         


Tyr Ser Pro Pro Leu Asn Val Ala Gln Arg Tyr Val Val Ala Cys Lys 
        275                 280                 285             


Glu Pro Lys Lys Lys 
    290             


<210>  1657
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC102B__Homo_sapiens__NP_001087198

<400>  1657

Met Asn Leu Asp Ser Ile His Arg Leu Ile Glu Glu Thr Gln Ile Phe 
1               5                   10                  15      


Gln Met Gln Gln Ser Ser Ile Lys Ser Arg Gly Asp Met Val Ala Pro 
            20                  25                  30          


Ala Ser Pro Pro Arg Asp Thr Cys Asn Thr Cys Phe Pro Leu His Gly 
        35                  40                  45              


Leu Gln Ser His Ala Ala His Asn Phe Cys Ala His Ser Tyr Asn Thr 
    50                  55                  60                  


Asn Lys Trp Asp Ile Cys Glu Glu Leu Arg Leu Arg Glu Leu Glu Glu 
65                  70                  75                  80  


Val Lys Ala Arg Ala Ala Gln Met Glu Lys Thr Met Arg Trp Trp Ser 
                85                  90                  95      


Asp Cys Thr Ala Asn Trp Arg Glu Lys Trp Ser Lys Val Arg Ala Glu 
            100                 105                 110         


Arg Asn Ser Ala Arg Glu Glu Gly Arg Gln Leu Arg Ile Lys Leu Glu 
        115                 120                 125             


Met Ala Met Lys Glu Leu Ser Thr Leu Lys Lys Lys Gln Ser Leu Pro 
    130                 135                 140                 


Pro Gln Lys Glu Ala Leu Glu Ala Asn Val Thr Gln Asp Leu Lys Leu 
145                 150                 155                 160 


Pro Gly Phe Val Glu Glu Ser Cys Glu His Thr Asp Gln Phe Gln Leu 
                165                 170                 175     


Ser Ser Gln Met His Glu Ser Ile Arg Glu Tyr Leu Val Lys Arg Gln 
            180                 185                 190         


Phe Ser Thr Lys Glu Asp Thr Asn Asn Lys Glu Gln Gly Val Val Ile 
        195                 200                 205             


Asp Ser Leu Lys Leu Ser Glu Glu Met Lys Pro Asn Leu Asp Gly Val 
    210                 215                 220                 


Asp Leu Phe Asn Asn Gly Gly Ser Gly Asn Gly Glu Thr Lys Thr Gly 
225                 230                 235                 240 


Leu Arg Leu Lys Ala Ile Asn Leu Pro Leu Glu Asn Glu Val Thr Glu 
                245                 250                 255     


Ile Ser Ala Leu Gln Val His Leu Asp Glu Phe Gln Lys Ile Leu Trp 
            260                 265                 270         


Lys Glu Arg Glu Met Arg Thr Ala Leu Glu Lys Glu Ile Glu Arg Leu 
        275                 280                 285             


Glu Ser Ala Leu Ser Leu Trp Lys Trp Lys Tyr Glu Glu Leu Lys Glu 
    290                 295                 300                 


Ser Lys Pro Lys Asn Val Lys Glu Phe Asp Ile Leu Leu Gly Gln His 
305                 310                 315                 320 


Asn Asp Glu Met Gln Glu Leu Ser Gly Asn Ile Lys Glu Glu Ser Lys 
                325                 330                 335     


Ser Gln Asn Ser Lys Asp Arg Val Ile Cys Glu Leu Arg Ala Glu Leu 
            340                 345                 350         


Glu Arg Leu Gln Ala Glu Asn Thr Ser Glu Trp Asp Lys Arg Glu Ile 
        355                 360                 365             


Leu Glu Arg Glu Lys Gln Gly Leu Glu Arg Glu Asn Arg Arg Leu Lys 
    370                 375                 380                 


Ile Gln Val Lys Glu Met Glu Glu Leu Leu Asp Lys Lys Asn Arg Leu 
385                 390                 395                 400 


Ser Ala Asn Ser Gln Ser Pro Asp Phe Lys Met Ser Gln Ile Asp Leu 
                405                 410                 415     


Gln Glu Lys Asn Gln Glu Leu Leu Asn Leu Gln His Ala Tyr Tyr Lys 
            420                 425                 430         


Leu Asn Arg Gln Tyr Gln Ala Asn Ile Ala Glu Leu Thr His Ala Asn 
        435                 440                 445             


Asn Arg Val Asp Gln Asn Glu Ala Glu Val Lys Lys Leu Arg Leu Arg 
    450                 455                 460                 


Val Glu Glu Leu Lys Gln Gly Leu Asn Gln Lys Glu Asp Glu Leu Asp 
465                 470                 475                 480 


Asp Ser Leu Asn Gln Ile Arg Lys Leu Gln Arg Ser Leu Asp Glu Glu 
                485                 490                 495     


Lys Glu Arg Asn Glu Asn Leu Glu Thr Glu Leu Arg His Leu Gln Asn 
            500                 505                 510         


Trp 
    


<210>  1658
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC103__Homo_sapiens__NP_001245326

<400>  1658

Met Glu Arg Asn Asp Ile Ile Asn Phe Lys Ala Leu Glu Lys Glu Leu 
1               5                   10                  15      


Gln Ala Ala Leu Thr Ala Asp Glu Lys Tyr Lys Arg Glu Asn Ala Ala 
            20                  25                  30          


Lys Leu Arg Ala Val Glu Gln Arg Val Ala Ser Tyr Glu Glu Phe Arg 
        35                  40                  45              


Gly Ile Val Leu Ala Ser His Leu Lys Pro Leu Glu Arg Lys Asp Lys 
    50                  55                  60                  


Met Gly Gly Lys Arg Thr Val Pro Trp Asn Cys His Thr Ile Gln Gly 
65                  70                  75                  80  


Arg Thr Phe Gln Asp Val Ala Thr Glu Ile Ser Pro Asn Ser Trp Lys 
                85                  90                  95      


Ser Ser 
        


<210>  1659
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC105__Homo_sapiens__NP_775753

<400>  1659

Met Arg Val Leu Val Pro Pro Ala Glu Arg Ser Gln Asp Thr Arg Val 
1               5                   10                  15      


Gly Ala Pro Ala Trp Arg Glu Ala Ala Gln Ala Met Ala Arg Thr Ala 
            20                  25                  30          


His Ile Leu Thr Asp Arg Cys Gly Gln Glu Ala Val Thr Met Trp Gln 
        35                  40                  45              


Pro Lys Asp Ser Val Leu Asp Pro Asn Val Ala His His Leu Gly Arg 
    50                  55                  60                  


Ala Ala Tyr Ile Gln Pro Trp Arg Phe Arg Val Glu Met Ile Lys Gly 
65                  70                  75                  80  


Gly Gly Thr Leu Glu Lys Pro Pro Pro Gly Glu Gly Val Thr Leu Trp 
                85                  90                  95      


Lys Gly Lys Met Lys Pro Pro Ala Trp Tyr Ala Arg Leu Pro Leu Pro 
            100                 105                 110         


Leu His Arg Lys Ala Arg Ala Leu Gln Thr Thr Glu Val Val His Ala 
        115                 120                 125             


His Ala Arg Gly Ala Arg Leu Thr Ala Ala Arg Leu Gly Arg Ala Gln 
    130                 135                 140                 


His Gln Ile Asn Gly Arg Val Arg Gln Leu Leu Arg Gln Arg Glu Val 
145                 150                 155                 160 


Thr Asp His Arg Leu Ser Glu Val Arg Lys Gly Leu Leu Ile Asn Gln 
                165                 170                 175     


Gln Ser Val Lys Leu Arg Gly Tyr Arg Pro Lys Ser Glu Lys Val Pro 
            180                 185                 190         


Asp Lys Ala Asp Ser Met Leu Thr Trp Glu Lys Glu Glu Leu Lys Ser 
        195                 200                 205             


Met Lys Arg Lys Met Glu Arg Asp Met Glu Lys Ser Glu Val Leu Leu 
    210                 215                 220                 


Lys Thr Leu Ala Ser Cys Arg Asp Thr Leu Asn Phe Cys Phe Lys Glu 
225                 230                 235                 240 


Arg Leu Gln Ala Val Asp Leu Met Asn Gln Pro Leu Asp Lys Val Leu 
                245                 250                 255     


Glu Gln Ala Arg Arg His Ser Trp Val Asn Leu Ser Arg Ala Pro Thr 
            260                 265                 270         


Pro Arg Thr Gln Gly Gln Lys Thr Pro Pro Pro Asp Pro Val Gly Thr 
        275                 280                 285             


Tyr Asn Pro Ala Cys Ala Leu Ala Leu Asn Glu Ala Lys Arg Leu Leu 
    290                 295                 300                 


Val Glu Ser Lys Asp Thr Leu Val Glu Met Ala Lys Asn Glu Val Asp 
305                 310                 315                 320 


Val Arg Glu Gln Gln Leu Gln Ile Ser Asp Arg Val Cys Ala Ser Leu 
                325                 330                 335     


Ala Gln Lys Ala Ser Glu Thr Leu Glu Leu Lys Glu Arg Leu Asn Met 
            340                 345                 350         


Thr Leu Gly Leu Met Arg Gly Thr Ile Leu Arg Cys Thr Lys Tyr Asn 
        355                 360                 365             


Gln Glu Leu Tyr Thr Thr His Gly Leu Ile Lys Gly Pro Leu Ser Lys 
    370                 375                 380                 


Val His Leu Glu Thr Ala Glu Lys Leu Asp Arg Pro Leu Val Arg Met 
385                 390                 395                 400 


Tyr Gln Arg His Val Gly Thr Gln Leu Pro Glu Ala Ala Arg Leu Ala 
                405                 410                 415     


Gln Gly Thr Asp Lys Leu Gln Cys His Ile Thr Tyr Leu Glu Lys Asn 
            420                 425                 430         


Leu Asp Glu Leu Leu Ala Thr His Lys Asn Leu Ser Trp Gly Leu Asn 
        435                 440                 445             


Cys Lys Asn Ile Gly His Glu Val Asp Gly Asn Val Val Arg Leu Arg 
    450                 455                 460                 


Leu Arg Gln Arg Gln Pro His Val Cys Tyr Glu Gln Ala Gln Arg Leu 
465                 470                 475                 480 


Val Lys Asp Trp Asp Pro Arg Thr Pro Pro Pro Arg Ser Lys Ser Ser 
                485                 490                 495     


Ala Asp Pro 
            


<210>  1660
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC108__Homo_sapiens__NP_001265224

<400>  1660

Met Glu Thr Ala Ile Trp Arg Arg Ser Tyr Ile Ser Leu Ile Ser Ser 
1               5                   10                  15      


Glu Arg Pro Val His Asn Trp Arg Gly Lys Ser Val Gln Lys Lys Gln 
            20                  25                  30          


Ala Glu Ser Lys Ser Gln Ile Lys Leu His Thr Gln Ser Ala Pro Phe 
        35                  40                  45              


Gly Leu Cys Pro Lys Asp Met Met Leu Thr Gln Ala Pro Ser Ser Val 
    50                  55                  60                  


Val Arg Ser Arg Asn Ser Arg Asn His Thr Val Asn Ser Gly Gly Ser 
65                  70                  75                  80  


Cys Leu Ser Ala Ser Thr Val Ala Ile Pro Ala Ile Asn Asp Ser Ser 
                85                  90                  95      


Ala Ala Met Ser Ala Cys Ser Thr Ile Ser Ala Gln Pro Ala Ser Ser 
            100                 105                 110         


Met Asp Thr Gln Met His Ser Pro Lys Lys Gln Glu Arg Val Asn Lys 
        115                 120                 125             


Arg Val Ile Trp Gly Ile Glu Val Ala Glu Glu Leu His Trp Lys Gly 
    130                 135                 140                 


Trp Glu Leu Gly Lys Glu Thr Thr Arg Asn Leu Val Leu Lys Asn Arg 
145                 150                 155                 160 


Ser Leu Lys Leu Gln Lys Met Lys Tyr Arg Pro Pro Lys Thr Lys Phe 
                165                 170                 175     


Phe Phe Thr Val Ile Pro Gln Pro Ile Phe Leu Ser Pro Gly Ile Thr 
            180                 185                 190         


Leu Thr Leu Pro Ile Val Phe Arg Pro Leu Glu Ala Lys Glu Tyr Met 
        195                 200                 205             


Asp Gln Leu Trp Phe Glu Lys Ala Glu Gly Met Phe Cys Val Gly Leu 
    210                 215                 220                 


Arg Ala Thr Leu Pro Cys His Arg Leu Ile Cys Arg Pro Pro Ser Leu 
225                 230                 235                 240 


Gln Leu Pro Met Cys Ala Val Gly Asp Thr Thr Glu Ala Phe Phe Cys 
                245                 250                 255     


Leu Asp Asn Val Gly Asp Leu Pro Thr Phe Phe Thr Trp Glu Phe Ser 
            260                 265                 270         


Ser Pro Phe Gln Met Leu Pro Ala Thr Gly Leu Leu Glu Pro Gly Gln 
        275                 280                 285             


Ala Ser Gln Ile Lys Val Thr Phe Gln Pro Leu Thr Ala Val Ile Tyr 
    290                 295                 300                 


Glu Val Gln Ala Thr Cys Trp Tyr Gly Ala Gly Ser Arg Gln Arg Ser 
305                 310                 315                 320 


Ser Ile Gln Leu Gln Ala Val Ala Lys Cys Ala Gln Leu Leu Val Ser 
                325                 330                 335     


Ile Lys His Lys Cys Pro Glu Asp Gln Asp Ala Glu Gly Phe Gln Lys 
            340                 345                 350         


Leu Leu Tyr Phe Gly Ser Val Ala Val Gly Cys Thr Ser Glu Arg Gln 
        355                 360                 365             


Ile Arg Leu His Asn Pro Ser Ala Val Asn Ala Pro Phe Arg Ile Glu 
    370                 375                 380                 


Ile Ser Pro Asp Glu Leu Ala Glu Asp Gln Ala Phe Ser Cys Pro Thr 
385                 390                 395                 400 


Ala His Gly Ile Val Leu Pro Gly Glu Lys Lys Cys Val Ser Val Phe 
                405                 410                 415     


Phe His Pro Lys Thr Leu Asp Thr Arg Thr Val Asp Tyr Cys Ser Ile 
            420                 425                 430         


Met Pro Ser Gly Cys Ala Ser Lys Thr Leu Leu Lys Val Val Gly Phe 
        435                 440                 445             


Cys Arg Gly Pro Ala Val Ser Leu Gln His Tyr Cys Val Asn Phe Ser 
    450                 455                 460                 


Trp Val Asn Leu Gly Glu Arg Ser Glu Gln Pro Leu Trp Ile Glu Asn 
465                 470                 475                 480 


Gln Ser Asp Cys Thr Ala His Phe Gln Phe Ala Ile Asp Cys Leu Glu 
                485                 490                 495     


Ser Val Phe Thr Ile Arg Pro Ala Phe Gly Thr Leu Val Gly Lys Ala 
            500                 505                 510         


Arg Met Thr Leu His Cys Ala Phe Gln Pro Thr His Pro Ile Ile Cys 
        515                 520                 525             


Phe Arg Arg Val Ala Cys Leu Ile His His Gln Asp Pro Leu Phe Leu 
    530                 535                 540                 


Asp Leu Met Gly Thr Cys His Ser Asp Ser Thr Lys Pro Ala Ile Leu 
545                 550                 555                 560 


Lys Pro Gln His Leu Thr Trp Tyr Arg Thr His Leu Ala Arg Gly Leu 
                565                 570                 575     


Thr Leu Tyr Pro Pro Asp Ile Leu Asp Ala Met Leu Lys Glu Lys Lys 
            580                 585                 590         


Leu Ala Gln Asp Gln Asn Gly Ala Leu Met Ile Pro Ile Gln Asp Leu 
        595                 600                 605             


Glu Asp Met Pro Ala Pro Gln Tyr Pro Tyr Ile Pro Pro Met Thr Glu 
    610                 615                 620                 


Phe Phe Phe Asp Gly Thr Ser Asp Ile Thr Ile Phe Pro Pro Pro Ile 
625                 630                 635                 640 


Ser Val Glu Pro Val Glu Val Asp Phe Gly Ala Cys Pro Gly Pro Glu 
                645                 650                 655     


Ala Pro Asn Pro Val Pro Leu Cys Leu Met Asn His Thr Lys Gly Lys 
            660                 665                 670         


Ile Met Val Val Trp Thr Arg Arg Ser Asp Cys Pro Phe Trp Val Thr 
        675                 680                 685             


Pro Glu Ser Cys Asp Val Pro Pro Leu Lys Ser Met Ala Met Arg Leu 
    690                 695                 700                 


His Phe Gln Pro Pro His Pro Asn Cys Leu Tyr Thr Val Glu Leu Glu 
705                 710                 715                 720 


Ala Phe Ala Ile Tyr Lys Val Cys Ala Arg Asn Glu Arg Glu Glu Cys 
                725                 730                 735     


Gly Val Ser Ala Arg Ser Leu Ser Gly Leu Val Gly Trp Gln Glu Val 
            740                 745                 750         


Thr Glu Gly Ser Phe Arg Leu His Pro Leu Arg Ala Arg Leu Ser Leu 
        755                 760                 765             


Gly Trp Thr Val Thr Pro Met Ser Leu Ser Pro Pro Lys Leu Leu Ala 
    770                 775                 780                 


<210>  1661
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC114__Homo_sapiens__NP_653178

<400>  1661

Met Glu Gly Glu Arg Arg Ala Tyr Ser Lys Glu Val His Gln Arg Ile 
1               5                   10                  15      


Asn Lys Gln Leu Glu Glu Ile Arg Arg Leu Glu Glu Val Arg Gly Asp 
            20                  25                  30          


Leu Gln Val Gln Ile Ser Ala Ala Gln Asn Gln Val Lys Arg Leu Arg 
        35                  40                  45              


Asp Ser Gln Arg Leu Glu Asn Met Asp Arg Leu Leu Lys Gly Arg Ala 
    50                  55                  60                  


Gln Val Gln Ala Glu Ile Glu Glu Leu Gln Glu Gln Thr Arg Ala Leu 
65                  70                  75                  80  


Asp Lys Gln Ile Gln Glu Trp Glu Thr Arg Ile Phe Thr His Ser Lys 
                85                  90                  95      


Asn Val Arg Ser Pro Gly Phe Ile Leu Asp Gln Lys Val Lys Ile Arg 
            100                 105                 110         


Arg Arg Ile Arg Ile Leu Glu Asn Gln Leu Asp Arg Val Thr Cys His 
        115                 120                 125             


Phe Asp Asn Gln Leu Val Arg Asn Ala Ala Leu Arg Glu Glu Leu Asp 
    130                 135                 140                 


Leu Leu Arg Ile Asp Arg Asn Arg Tyr Leu Asn Val Asp Arg Lys Leu 
145                 150                 155                 160 


Lys Lys Glu Ile His His Leu His His Leu Val Ser Thr Leu Ile Leu 
                165                 170                 175     


Ser Ser Thr Ser Ala Tyr Ala Val Arg Glu Glu Ala Lys Ala Lys Met 
            180                 185                 190         


Gly Leu Leu Arg Glu Arg Ala Glu Lys Glu Glu Ala Gln Ser Glu Met 
        195                 200                 205             


Glu Ala Gln Val Leu Gln Arg Gln Ile Leu His Leu Glu Gln Leu His 
    210                 215                 220                 


His Phe Leu Lys Leu Lys Asn Asn Asp Arg Gln Pro Asp Pro Asp Val 
225                 230                 235                 240 


Leu Glu Lys Arg Glu Lys Gln Ala Gly Glu Val Ala Glu Gly Val Trp 
                245                 250                 255     


Lys Thr Ser Gln Glu Arg Leu Val Leu Cys Tyr Glu Asp Ala Leu Asn 
            260                 265                 270         


Lys Leu Ser Gln Leu Met Gly Glu Ser Asp Pro Asp Leu Leu Val Gln 
        275                 280                 285             


Lys Tyr Leu Glu Ile Glu Glu Arg Asn Phe Ala Glu Phe Asn Phe Ile 
    290                 295                 300                 


Asn Glu Gln Asn Leu Glu Leu Glu His Val Gln Glu Glu Ile Lys Glu 
305                 310                 315                 320 


Met Gln Glu Ala Leu Val Ser Ala Arg Ala Ser Lys Asp Asp Gln His 
                325                 330                 335     


Leu Leu Gln Glu Gln Gln Gln Lys Val Leu Gln Gln Arg Met Asp Lys 
            340                 345                 350         


Val His Ser Glu Ala Glu Arg Leu Glu Ala Arg Phe Gln Asp Val Arg 
        355                 360                 365             


Gly Gln Leu Glu Lys Leu Lys Ala Asp Ile Gln Leu Leu Phe Thr Lys 
    370                 375                 380                 


Ala His Cys Asp Ser Ser Met Ile Asp Asp Leu Leu Gly Val Lys Thr 
385                 390                 395                 400 


Ser Met Gly Asp Arg Asp Met Gly Leu Phe Leu Ser Leu Ile Glu Lys 
                405                 410                 415     


Arg Leu Val Glu Leu Leu Thr Val Gln Ala Phe Leu His Ala Gln Ser 
            420                 425                 430         


Phe Thr Ser Leu Ala Asp Ala Ala Leu Leu Val Leu Gly Gln Ser Leu 
        435                 440                 445             


Glu Asp Leu Pro Lys Lys Met Ala Pro Leu Gln Pro Pro Asp Thr Leu 
    450                 455                 460                 


Glu Asp Pro Pro Gly Phe Glu Ala Ser Asp Asp Tyr Pro Met Ser Arg 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Gln Val Glu Lys Leu Val Glu Leu Gln Glu Gln 
                485                 490                 495     


Ala Glu Ala Gln Arg Gln Lys Asp Leu Ala Ala Ala Ala Ala Lys Leu 
            500                 505                 510         


Asp Gly Thr Leu Ser Val Asp Leu Ala Ser Thr Gln Arg Ala Gly Ser 
        515                 520                 525             


Ser Thr Val Leu Val Pro Thr Arg His Pro His Ala Ile Pro Gly Ser 
    530                 535                 540                 


Ile Leu Ser His Lys Thr Ser Arg Asp Arg Gly Ser Leu Gly His Val 
545                 550                 555                 560 


Thr Phe Gly Gly Leu Ser Ser Ser Thr Gly His Leu Pro Ser His Ile 
                565                 570                 575     


Thr His Gly Asp Pro Asn Thr Gly His Val Thr Phe Gly Ser Thr Ser 
            580                 585                 590         


Ala Ser Ser Gly Gly His Val Thr Phe Arg Pro Val Ser Ala Ser Ser 
        595                 600                 605             


Tyr Leu Gly Ser Thr Gly Tyr Val Gly Ser Ser Arg Gly Gly Glu Asn 
    610                 615                 620                 


Thr Glu Gly Gly Val Glu Ser Gly Gly Thr Ala Ser Asp Ser Ser Gly 
625                 630                 635                 640 


Gly Leu Gly Ser Ser Arg Asp His Val Ser Ser Thr Gly Pro Ala Ser 
                645                 650                 655     


Ser Thr Gly Pro Gly Ser Ser Thr Ser Lys Asp Ser Arg Gly 
            660                 665                 670 


<210>  1662
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC115__Homo_sapiens__NP_115733

<400>  1662

Met Ala Ala Leu Asp Leu Arg Ala Glu Leu Asp Ser Leu Val Leu Gln 
1               5                   10                  15      


Leu Leu Gly Asp Leu Glu Glu Leu Glu Gly Lys Arg Thr Val Leu Asn 
            20                  25                  30          


Ala Arg Val Glu Glu Gly Trp Leu Ser Leu Ala Lys Ala Arg Tyr Ala 
        35                  40                  45              


Met Gly Ala Lys Ser Val Gly Pro Leu Gln Tyr Ala Ser His Met Glu 
    50                  55                  60                  


Pro Gln Val Cys Leu His Ala Ser Glu Ala Gln Glu Gly Leu Gln Lys 
65                  70                  75                  80  


Phe Lys Val Val Arg Ala Gly Val His Ala Pro Glu Glu Val Gly Pro 
                85                  90                  95      


Arg Glu Ala Gly Leu Arg Arg Arg Lys Gly Pro Thr Lys Thr Pro Glu 
            100                 105                 110         


Pro Glu Ser Ser Glu Ala Pro Gln Asp Pro Leu Asn Trp Phe Gly Ile 
        115                 120                 125             


Leu Val Pro His Ser Leu Arg Gln Ala Gln Ala Ser Phe Arg Asp Gly 
    130                 135                 140                 


Leu Gln Leu Ala Ala Asp Ile Ala Ser Leu Gln Asn Arg Ile Asp Trp 
145                 150                 155                 160 


Gly Arg Ser Gln Leu Arg Gly Leu Gln Glu Lys Leu Lys Gln Leu Glu 
                165                 170                 175     


Pro Gly Ala Ala 
            180 


<210>  1663
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC121__Homo_sapiens__NP_001136155

<400>  1663

Met Gly Ser Arg Gly Gln Gly Ser His Ser Lys Lys Thr Arg Ser Met 
1               5                   10                  15      


Pro Val Ile Leu Ser Pro Gln Arg Thr Gly Ser Gly Ala Thr Gly Gly 
            20                  25                  30          


Pro Ala Ala Arg Ala Tyr Ser Val Ala Glu Ala Val Lys Gln Phe Arg 
        35                  40                  45              


Ala Gly Pro Ala Gly Thr Gly Ala Gly Cys Ser Leu Gln Gly Cys Trp 
    50                  55                  60                  


Ala Ala Pro Arg Pro Phe Glu His Arg Thr Asn Lys Leu Arg Glu Leu 
65                  70                  75                  80  


Ser Thr Leu Ala His Cys Ser Arg Glu Leu Gln Thr Gln Val Pro Asp 
                85                  90                  95      


Ala Ser Ala His Ser Leu Ala Val Thr Leu Ser Glu Leu His Ser Cys 
            100                 105                 110         


Arg Asp Leu Gln Asp Glu Cys Leu Asp Ser Arg Phe Ala Glu Gly Pro 
        115                 120                 125             


Arg Arg Leu Leu Pro Pro Tyr His Ser Leu Ile Asn Asn Phe Val Lys 
    130                 135                 140                 


Pro Glu Lys Leu Thr Lys Val Glu Thr Arg Leu Lys Glu Lys Ile Val 
145                 150                 155                 160 


Ala Glu Met Thr Asp Leu Asn Lys His Ile Lys Gln Ala Gln Thr Gln 
                165                 170                 175     


Arg Lys Gln Leu Leu Glu Glu Ser Arg Glu Leu His Arg Glu Lys Leu 
            180                 185                 190         


Leu Val Gln Ala Glu Asn Arg Phe Phe Leu Glu Tyr Leu Thr Asn Lys 
        195                 200                 205             


Thr Glu Glu Tyr Thr Glu Gln Pro Glu Lys Val Trp Asn Ser Tyr Leu 
    210                 215                 220                 


Gln Lys Ser Gly Glu Ile Glu Arg Arg Arg Gln Glu Ser Ala Ser Arg 
225                 230                 235                 240 


Tyr Ala Glu Gln Ile Ser Val Leu Lys Thr Ala Leu Leu Gln Lys Glu 
                245                 250                 255     


Asn Ile Gln Ser Ser Leu Lys Arg Lys Leu Gln Ala Met Arg Asp Ile 
            260                 265                 270         


Ala Ile Leu Lys Glu Lys Gln Glu Lys Glu Ile Gln Thr Leu Gln Glu 
        275                 280                 285             


Glu Thr Lys Lys Val Gln Ala Glu Thr Ala Ser Lys Thr Arg Glu Val 
    290                 295                 300                 


Gln Ala Gln Leu Leu Gln Glu Lys Arg Leu Leu Glu Lys Gln Leu Ser 
305                 310                 315                 320 


Glu Pro Asp Arg Arg Leu Leu Gly Lys Arg Lys Arg Arg Glu Leu Asn 
                325                 330                 335     


Met Lys Ala Gln Ala Leu Lys Leu Ala Ala Lys Arg Phe Ile Phe Glu 
            340                 345                 350         


Tyr Ser Cys Gly Ile Asn Arg Glu Asn Gln Gln Phe Lys Lys Glu Leu 
        355                 360                 365             


Leu Gln Leu Ile Glu Gln Ala Gln Lys Leu Thr Ala Thr Gln Ser His 
    370                 375                 380                 


Leu Glu Asn Arg Lys Gln Gln Leu Gln Gln Glu Gln Trp Tyr Leu Glu 
385                 390                 395                 400 


Ser Leu Ile Gln Ala Arg Gln Arg Leu Gln Gly Ser His Asn Gln Cys 
                405                 410                 415     


Leu Asn Arg Gln Asp Val Pro Lys Thr Thr Pro Ser Leu Pro Gln Gly 
            420                 425                 430         


Thr Lys Ser Arg Ile Asn Pro Lys 
        435                 440 


<210>  1664
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC122__Homo_sapiens__NP_659411

<400>  1664

Met Ser Asp Asn Lys Glu Arg Lys Ser Gln Gly Phe Pro Lys Glu Asp 
1               5                   10                  15      


Asn Gln Asp Thr Ser Ser Leu Ala Asp Ala Val Glu Lys Val Ala Lys 
            20                  25                  30          


Gln Gln Gln Ser Gln Ala Ser Glu Ile Glu Lys Asn Lys Lys Val Leu 
        35                  40                  45              


Phe Asn Leu Lys Asn Glu Leu His Glu Leu Glu Lys Glu Ile Ala Ala 
    50                  55                  60                  


Ile Ser Ala Glu Thr Lys Glu Thr Glu Arg Gln Ile Tyr Gln Gln Asp 
65                  70                  75                  80  


Ser Ala Ile Glu Asn Thr Lys Leu His Cys Asp Ser Leu Glu Thr Gln 
                85                  90                  95      


Ile Lys Ser Leu His Ser Glu Asn Val Lys Leu Lys Phe Asp Ile Glu 
            100                 105                 110         


Thr Ala Gln Glu Asp Phe Glu Glu His Met Ile Lys Tyr Asn Ala Tyr 
        115                 120                 125             


Tyr Ala Lys Ile Lys Ala His Lys Asn Ser Leu Gly Glu Val Glu Ser 
    130                 135                 140                 


Lys Trp Ser Phe Met Thr Glu Leu His Glu Lys Arg Asp Phe Val Lys 
145                 150                 155                 160 


Lys Leu Lys Thr Met Lys Glu Glu Leu Met Gln Asp Leu Gln Asn Pro 
                165                 170                 175     


Gly Gly Asn Arg Ile Thr Gln Val Gln Glu Asp Ile Thr Asn Leu Lys 
            180                 185                 190         


Asp Lys Ile Ile Thr Val Lys Glu Ser Ile Ile Glu Lys Thr Cys Phe 
        195                 200                 205             


Leu Glu Glu Glu Lys Lys Thr His Glu Lys Leu Arg Lys Glu Ile Glu 
    210                 215                 220                 


Val Gln His Lys Arg Tyr Asp Ala Ile Leu Lys Arg Leu His Cys Gln 
225                 230                 235                 240 


Val Asn Lys Leu Gln Ser Asn Arg Arg Gln Trp Gln Trp Asn Ile Gln 
                245                 250                 255     


Gln Leu Glu Lys Thr Ala Ala Glu Leu Arg Lys Cys Ile Gly Met Gln 
            260                 265                 270         


Glu 
    


<210>  1665
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC129__Homo_sapiens__NP_001244896

<400>  1665

Met Ser Val Ser Leu Gln Asn Tyr Ser Pro Met Met Ala Gln Lys Ser 
1               5                   10                  15      


Gln Gly Ser Asp Asn Leu Gln Glu Gly Gln Glu Lys Ser Lys Arg Glu 
            20                  25                  30          


Ile Leu Lys Cys Thr Lys Ser Ala Trp Ala Pro Leu Asp Glu Trp Leu 
        35                  40                  45              


Pro Pro Asp Pro Glu Glu Glu Ser Gln Ser Leu Thr Ile Pro Met Leu 
    50                  55                  60                  


Glu Asp Ser Lys Gln Glu Ser Ile Gln Gln Trp Leu Asp Ser Gly Phe 
65                  70                  75                  80  


Phe Val Ser Ala Asn Glu Asn Phe Gln Gln Val Ile Asp Arg Thr Val 
                85                  90                  95      


Ser Leu Tyr Glu Gln Gly Met Val Gln Met Thr Val Lys Asp Tyr Met 
            100                 105                 110         


Arg Ser Leu His Gln Phe Ser Glu Thr Pro Ile Leu Ser Arg Gly Thr 
        115                 120                 125             


Ser Phe Asn Ser Cys Tyr Ser Thr Ala Ser Val Pro Gln Ser Ile Pro 
    130                 135                 140                 


Glu Trp Leu Glu Phe Trp Glu Ile Asp Pro Val Glu Ile Leu Leu Asp 
145                 150                 155                 160 


Leu Gly Phe Gly Ala Asp Glu Pro Asp Ile Cys Met Gln Ile Pro Ala 
                165                 170                 175     


Arg Phe Leu Gly Cys Gly Ser Ala Ala Arg Gly Ile Asn Ile Arg Val 
            180                 185                 190         


Phe Leu Glu Ala Gln Lys Gln Arg Met Asp Ile Glu Asn Pro Asn Leu 
        195                 200                 205             


Tyr Gly Arg Phe Arg Gln Leu Glu Ile Leu Asp His Val Thr Asn Ala 
    210                 215                 220                 


Phe Ser Ser Leu Leu Ser Asp Val Ser Ile Leu Pro Asn Arg Ala Glu 
225                 230                 235                 240 


Glu Lys Ala Gly Gly Glu Ser Val Gln Arg Thr Ser Val Ser Ala Ala 
                245                 250                 255     


Lys Glu His Arg Arg Arg Met Gly Lys Leu Leu Arg Arg Ala Ser Lys 
            260                 265                 270         


Gln Asn Ile Arg Arg Asp Cys Asn Pro Glu Val Ser Glu Ser Phe Lys 
        275                 280                 285             


Val Lys Asp Glu Val Phe Val Pro Phe Thr Lys Pro Trp Asp Cys Gly 
    290                 295                 300                 


Ala Glu Leu Ala Ala Thr Ser Ile Asn His Lys Gln Asn His Leu Ser 
305                 310                 315                 320 


Leu Ser Val Glu His Gln Ser Leu Gln Ala Cys Asp Asp Leu Leu Pro 
                325                 330                 335     


Tyr Pro Pro His Gly Leu Leu Ser Lys Gln Trp Pro Cys Ser Ser Met 
            340                 345                 350         


Pro Ala Lys Gln Ala Pro Pro Ser Cys Val Ser Glu Gly Ser Val Lys 
        355                 360                 365             


Gly Arg Thr Gln Lys Glu Asn Leu Phe Gln Thr Asn Lys Leu Lys Ser 
    370                 375                 380                 


Leu Ser His Leu Ala Gly Lys Gly Pro Asp Ser Phe Glu Met Glu Glu 
385                 390                 395                 400 


Val Gln Ser Phe Glu Glu Glu Thr Gly Asn Pro Leu Asp Met Thr Ser 
                405                 410                 415     


Gly Thr Val Gly Ala Arg Val Asp Arg Ala Asn Ser Cys Gln Ser Asp 
            420                 425                 430         


Ser Ser Gly Phe Leu Glu Glu Pro Leu Glu Pro Leu Pro Leu Gln Met 
        435                 440                 445             


Pro Ser Leu Pro Asn Ser Gln Ser Pro Ala Glu Asn Gly Gly Arg Lys 
    450                 455                 460                 


Pro Arg Asp Gln Ser His Ser Leu Val Ser Ser Gln Asp Cys Gln Leu 
465                 470                 475                 480 


Glu Ser Asp Gly Pro Asp Ser Lys Ser Arg Ala Ser Met Ser Phe Ser 
                485                 490                 495     


Ser Gln Glu Ala Asn Ala Leu Glu Gln Arg Ala Ser Val Ser Val Met 
            500                 505                 510         


Glu Glu Glu Phe Leu Leu Glu Ala Met Glu Gly Pro Pro Glu Leu Tyr 
        515                 520                 525             


Ile Pro Asp Met Ala Cys Ala Lys Thr Thr Thr Arg Gly Glu Cys Pro 
    530                 535                 540                 


Arg Lys Asp Ser His Leu Trp Gln Leu Leu Pro Met Pro His Ala Glu 
545                 550                 555                 560 


Tyr Glu Val Thr Arg Pro Thr Ala Thr Ser Lys Tyr Asp His Pro Leu 
                565                 570                 575     


Gly Phe Met Val Thr His Val Thr Glu Met Gln Asp Ser Phe Val Arg 
            580                 585                 590         


Pro Glu Gly Ala Gly Lys Val Gln Ser His His Asn Glu Ser Gln Arg 
        595                 600                 605             


Ser Pro Gly Asn Asp His Thr Gln Asp Lys Phe Leu His Val Asp Ser 
    610                 615                 620                 


Glu Ala Pro Arg Glu Glu Glu Ser Ser Gly Phe Cys Pro His Thr Asn 
625                 630                 635                 640 


His Ser Leu Leu Val Pro Glu Ser Ser Ser Gln Cys Ile Pro Lys His 
                645                 650                 655     


Ser Glu Ile Thr Pro Tyr Ala Thr Asp Leu Ala Gln Thr Ser Glu Lys 
            660                 665                 670         


Leu Ile Pro His Leu His Lys Leu Pro Gly Asp Pro Ala Gln Val Lys 
        675                 680                 685             


Ser Arg Ser Gly Thr Leu Gly Gln Ile Leu Pro Gly Thr Glu Ala Glu 
    690                 695                 700                 


Met Glu Asn Leu Pro Leu Asn Thr Gly Ser Ser Arg Ser Val Met Thr 
705                 710                 715                 720 


Gln Met Ser Ser Ser Leu Val Ser Ala Ala Gln Arg Ala Val Ala Leu 
                725                 730                 735     


Gly Thr Gly Pro Arg Gly Thr Ser Leu Glu Cys Thr Val Cys Asp Pro 
            740                 745                 750         


Val Thr Ala Thr Glu Thr Arg Leu Gly Thr Lys Ala Arg Gln Leu Asn 
        755                 760                 765             


Asp Ala Ser Ile Gln Thr Ser Ala Leu Ser Asn Lys Thr Leu Thr His 
    770                 775                 780                 


Gly Pro Gln Pro Leu Thr Lys Ser Val Ser Leu Asp Ser Gly Phe Ser 
785                 790                 795                 800 


Ser Ile Cys Pro Met Gly Thr Cys His Ala Ile Pro Ala His Cys Cys 
                805                 810                 815     


Ile Cys Cys His His His Pro His Cys His Gly Glu Arg Gln Ser Pro 
            820                 825                 830         


Gly Pro Glu Pro Ser Val Cys Arg His Cys Leu Cys Ser Leu Thr Gly 
        835                 840                 845             


His Gln Glu Ala Gln Phe Met Thr Thr Leu Lys Ala Leu Gln Asp Thr 
    850                 855                 860                 


Thr Val Arg Glu Leu Cys Ser Cys Thr Val His Glu Met Glu Ala Met 
865                 870                 875                 880 


Lys Thr Ile Cys Gln Ser Phe Arg Glu Tyr Leu Glu Glu Ile Glu Gln 
                885                 890                 895     


His Leu Met Gly Gln Gln Ala Leu Phe Ser Arg Asp Met Ser Glu Glu 
            900                 905                 910         


Glu Arg Glu Glu Ala Glu Gln Leu Gln Thr Leu Arg Glu Ala Leu Arg 
        915                 920                 925             


Gln Gln Val Ala Glu Leu Glu Phe Gln Leu Gly Asp Arg Ala Gln Gln 
    930                 935                 940                 


Ile Arg Glu Gly Ile Leu Leu Gln Leu Glu Val Leu Thr Ala Glu Pro 
945                 950                 955                 960 


Pro Glu His Tyr Ser Asn Leu His Gln Tyr Asn Trp Ile Glu Glu Ser 
                965                 970                 975     


Asn Gly Gln Thr Ser Cys Ser Lys Ile His Pro Gly Met Ala Pro Arg 
            980                 985                 990         


Thr Val Phe Pro Pro Asp Asp Gly  Gln Glu Ala Pro Cys  Ser Gly Gly 
        995                 1000                 1005             


Thr Gln  Leu Ala Ala Phe Thr  Pro Pro Thr Leu Glu  Asn Ser Thr 
    1010                 1015                 1020             


Arg Met  Ser Pro Ser Ser Ser  Ala Trp Ala Lys Leu  Gly Pro Thr 
    1025                 1030                 1035             


Pro Leu  Ser Asn Cys Pro Val  Gly Glu Lys Asp Ala  Asp Val Phe 
    1040                 1045                 1050             


Leu 
    


<210>  1666
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC130__Homo_sapiens__NP_110445

<400>  1666

Met Gly Glu Arg Lys Gly Val Asn Lys Tyr Tyr Pro Pro Asp Phe Asn 
1               5                   10                  15      


Pro Glu Lys His Gly Ser Leu Asn Arg Tyr His Asn Ser His Pro Leu 
            20                  25                  30          


Arg Glu Arg Ala Arg Lys Leu Ser Gln Gly Ile Leu Ile Ile Arg Phe 
        35                  40                  45              


Glu Met Pro Tyr Asn Ile Trp Cys Asp Gly Cys Lys Asn His Ile Gly 
    50                  55                  60                  


Met Gly Val Arg Tyr Asn Ala Glu Lys Lys Lys Val Gly Asn Tyr Tyr 
65                  70                  75                  80  


Thr Thr Pro Ile Tyr Arg Phe Arg Met Lys Cys His Leu Cys Val Asn 
                85                  90                  95      


Tyr Ile Glu Met Gln Thr Asp Pro Ala Asn Cys Asp Tyr Val Ile Val 
            100                 105                 110         


Ser Gly Ala Gln Arg Lys Glu Glu Arg Trp Asp Met Ala Asp Asn Glu 
        115                 120                 125             


Gln Val Leu Thr Thr Glu His Glu Lys Lys Gln Lys Leu Glu Thr Asp 
    130                 135                 140                 


Ala Met Phe Arg Leu Glu His Gly Glu Ala Asp Arg Ser Thr Leu Lys 
145                 150                 155                 160 


Lys Ala Leu Pro Thr Leu Ser His Ile Gln Glu Ala Gln Ser Ala Trp 
                165                 170                 175     


Lys Asp Asp Phe Ala Leu Asn Ser Met Leu Arg Arg Arg Phe Arg Glu 
            180                 185                 190         


Lys Lys Lys Ala Ile Gln Glu Glu Glu Glu Arg Asp Gln Ala Leu Gln 
        195                 200                 205             


Ala Lys Ala Ser Leu Thr Ile Pro Leu Val Pro Glu Thr Glu Asp Asp 
    210                 215                 220                 


Arg Lys Leu Ala Ala Leu Leu Lys Phe His Thr Leu Asp Ser Tyr Glu 
225                 230                 235                 240 


Asp Lys Gln Lys Leu Lys Arg Thr Glu Ile Ile Ser Arg Ser Trp Phe 
                245                 250                 255     


Pro Ser Ala Pro Gly Ser Ala Ser Ser Ser Lys Val Ser Gly Val Leu 
            260                 265                 270         


Lys Lys Leu Ala Gln Ser Arg Arg Thr Ala Leu Ala Thr Ser Pro Ile 
        275                 280                 285             


Thr Val Gly Asp Leu Gly Ile Val Arg Arg Arg Ser Arg Asp Val Pro 
    290                 295                 300                 


Glu Ser Pro Gln His Ala Ala Asp Thr Pro Lys Ser Gly Glu Pro Arg 
305                 310                 315                 320 


Val Pro Glu Glu Ala Ala Gln Asp Arg Pro Met Ser Pro Gly Asp Cys 
                325                 330                 335     


Pro Pro Glu Thr Thr Glu Thr Pro Lys Cys Ser Ser Pro Arg Gly Gln 
            340                 345                 350         


Glu Gly Ser Arg Gln Asp Lys Pro Leu Ser Pro Ala Gly Ser Ser Gln 
        355                 360                 365             


Glu Ala Ala Asp Thr Pro Asp Thr Arg His Pro Cys Ser Leu Gly Ser 
    370                 375                 380                 


Ser Leu Val Ala Asp Tyr Ser Asp Ser Glu Ser Glu 
385                 390                 395     


<210>  1667
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC134__Homo_sapiens__NP_001291726

<400>  1667

Met Asp Leu Leu Gln Phe Leu Ala Phe Leu Phe Val Leu Leu Leu Ser 
1               5                   10                  15      


Gly Met Gly Ala Thr Gly Thr Leu Arg Thr Ser Leu Asp Pro Ser Leu 
            20                  25                  30          


Glu Ile Tyr Lys Lys Met Phe Glu Val Lys Arg Arg Glu Gln Leu Leu 
        35                  40                  45              


Ala Leu Lys Asn Leu Ala Gln Leu Asn Asp Ile His Gln Gln Tyr Lys 
    50                  55                  60                  


Ile Leu Asp Val Met Leu Lys Gly Leu Phe Lys Phe Ile Pro Ser Thr 
65                  70                  75                  80  


Asp Pro Phe Gln Lys Ala Leu Arg Glu Glu Glu Lys Arg Arg Lys Lys 
                85                  90                  95      


Glu Glu Lys Arg Lys Glu Ile Arg Lys Gly Pro Arg Ile Ser Arg Ser 
            100                 105                 110         


Gln Ser Glu Leu 
        115     


<210>  1668
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC136__Homo_sapiens__NP_001188301

<400>  1668

Met Glu Ala Gly Ala Gly Ala Gly Ala Gly Ala Ala Gly Trp Ser Cys 
1               5                   10                  15      


Pro Gly Pro Gly Pro Thr Val Thr Thr Leu Gly Ser Tyr Glu Ala Ser 
            20                  25                  30          


Glu Gly Cys Glu Arg Lys Lys Gly Gln Arg Trp Gly Ser Leu Glu Arg 
        35                  40                  45              


Arg Gly Met Gln Ala Met Glu Gly Glu Val Leu Leu Pro Ala Leu Tyr 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Gln Val Gln Lys Gly Gly Ser Val Gly Ser Leu Ser Val Asn 
                85                  90                  95      


Lys His Arg Gly Leu Ser Leu Thr Glu Thr Glu Leu Glu Glu Leu Arg 
            100                 105                 110         


Ala Gln Val Leu Gln Leu Val Ala Glu Leu Glu Glu Thr Arg Glu Leu 
        115                 120                 125             


Ala Gly Gln His Glu Asp Asp Ser Leu Glu Leu Gln Gly Leu Leu Glu 
    130                 135                 140                 


Asp Glu Arg Leu Ala Ser Ala Gln Gln Ala Glu Val Phe Thr Lys Gln 
145                 150                 155                 160 


Ile Gln Gln Leu Gln Gly Glu Leu Arg Ser Leu Arg Glu Glu Ile Ser 
                165                 170                 175     


Leu Leu Glu His Glu Lys Glu Ser Glu Leu Lys Glu Ile Glu Gln Glu 
            180                 185                 190         


Leu His Leu Ala Gln Ala Glu Ile Gln Ser Leu Arg Gln Ala Ala Glu 
        195                 200                 205             


Asp Ser Ala Thr Glu His Glu Ser Asp Ile Ala Ser Leu Gln Glu Asp 
    210                 215                 220                 


Leu Cys Arg Met Gln Asn Glu Leu Glu Asp Met Glu Arg Ile Arg Gly 
225                 230                 235                 240 


Asp Tyr Glu Met Glu Ile Ala Ser Leu Arg Ala Glu Met Glu Met Lys 
                245                 250                 255     


Ser Ser Glu Pro Ser Glu Glu Leu Gln Glu Leu Arg Glu Arg Tyr His 
            260                 265                 270         


Phe Leu Asn Glu Glu Tyr Arg Ala Leu Gln Glu Ser Asn Ser Ser Leu 
        275                 280                 285             


Thr Gly Gln Leu Ala Asp Leu Glu Ser Glu Arg Thr Gln Arg Ala Thr 
    290                 295                 300                 


Glu Arg Trp Leu Gln Ser Gln Thr Leu Ser Met Thr Ser Ala Glu Ser 
305                 310                 315                 320 


Gln Thr Ser Glu Met Asp Phe Leu Glu Pro Asp Pro Glu Met Gln Leu 
                325                 330                 335     


Leu Arg Gln Gln Leu Arg Asp Ala Glu Glu Gln Met His Gly Met Lys 
            340                 345                 350         


Asn Lys Cys Gln Glu Leu Cys Cys Glu Leu Glu Glu Leu Gln His His 
        355                 360                 365             


Arg Gln Val Ser Glu Glu Glu Gln Arg Arg Leu Gln Arg Glu Leu Lys 
    370                 375                 380                 


Cys Ala Gln Asn Glu Val Leu Arg Phe Gln Thr Ser His Ser Val Thr 
385                 390                 395                 400 


Gln Ser Ser Pro Thr Pro Asn Pro Pro Ile Phe Ser Leu Pro Leu Val 
                405                 410                 415     


Gly Leu Val Val Ile Ser Ala Leu Leu Trp Cys Trp Trp Ala Glu Thr 
            420                 425                 430         


Ser Ser 
        


<210>  1669
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC140__Homo_sapiens__NP_694583

<400>  1669

Met Gly Asp Glu Cys Ser Asn Pro Asp Leu Leu Ala Glu Pro Gly Ser 
1               5                   10                  15      


Ser Pro Pro Trp Asp His Gly Asn Gln Arg Gln Glu Ala Ala Asn Glu 
            20                  25                  30          


Ser Asn Thr Arg Val Pro Arg Val Leu Lys Ala His Leu Gly Pro Glu 
        35                  40                  45              


Thr Ala Gln Pro Thr Lys Arg Ser Lys Arg Asn Arg Trp Arg Arg Gln 
    50                  55                  60                  


Ser Cys Gln Gly Pro Ser Pro Ala Arg Ser Gly Gln Phe Leu Gly Ser 
65                  70                  75                  80  


Ala Asp Leu Gly Leu Gln Arg Gly Val Leu Lys Ser Ala Ala Arg Thr 
                85                  90                  95      


Cys Leu Ser Glu Ile Ser Asn Ser Thr Arg Ala Ser Pro Glu Ser Ala 
            100                 105                 110         


Gln Ser Thr Asp Pro Gly Arg Ala Ala Arg Pro Arg Thr Arg Thr Leu 
        115                 120                 125             


Pro Thr Pro His Ser Phe Lys Ile Gly Glu Glu Ala Glu Glu Met Lys 
    130                 135                 140                 


Lys Lys Lys Glu Arg Lys Arg Arg Lys Glu Arg Lys Lys Glu Arg Asn 
145                 150                 155                 160 


Phe Lys Lys 
            


<210>  1670
<211>  1530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC141__Homo_sapiens__NP_775919

<400>  1670

Met Ser Ser Gln Gly Ser Pro Ser Val Ala Leu Ser Thr Thr Thr Val 
1               5                   10                  15      


Ser Ser Val Ala Val Gln Ala Gly Asp Ser Lys Ile Val Ile Ala Val 
            20                  25                  30          


Ile Lys Cys Gly Lys Trp Val Gln Leu Gln Leu Ala Glu Ser Gln Pro 
        35                  40                  45              


Asn Leu Leu Glu Ile Gly Ser Ser Gln Asp Glu Thr Lys Lys Leu Leu 
    50                  55                  60                  


His Asp His Glu Leu Leu Leu Ala Lys Leu Lys Ala Leu Glu Asp Arg 
65                  70                  75                  80  


Val Trp Glu Leu Leu Gln Glu Ala Asp Lys Thr Ala Glu Glu Asn Lys 
                85                  90                  95      


Asp Gln Ser Gln Val Tyr Asp Ala Met Ala Glu Thr Leu Gly Glu Ala 
            100                 105                 110         


Trp Ala Ala Leu Val Ser Met Leu Glu Arg Arg Thr Glu Leu Leu Arg 
        115                 120                 125             


Leu Thr Ser Glu Phe Phe Glu Asn Ala Leu Glu Phe Ala Ile Lys Ile 
    130                 135                 140                 


Asp Gln Ala Glu Asp Phe Leu Gln Asn Thr His Glu Phe Glu Ser Ala 
145                 150                 155                 160 


Glu Ser Leu Lys Ser Leu Leu Gln Leu His Glu His His Thr Lys Glu 
                165                 170                 175     


Leu Leu Glu Arg Ser Leu Ala Leu Leu Asn Lys Ser Gln Gln Leu Thr 
            180                 185                 190         


Asp Phe Ile Glu Lys Phe Lys Cys Glu Gly Pro Asn Val Asn Pro Glu 
        195                 200                 205             


Leu Thr Gln Gly Ala His Ser Ser Cys Leu Lys Val Asp Arg Leu Leu 
    210                 215                 220                 


Glu Leu Leu Gln Asp Arg Arg Arg Gln Leu Asp Lys Tyr Leu Lys Gln 
225                 230                 235                 240 


Gln Trp Gln Glu Leu Ser Gln Val Leu Gln Ile Cys Gln Trp Asp Gln 
                245                 250                 255     


Gln Glu Asn Gln Val Thr Cys Trp Phe Gln Lys Thr Ile Arg Asn Leu 
            260                 265                 270         


Gln Glu Gln Ser Leu Gly Ser Ser Leu Ser Asp Asn Glu Asp Arg Ile 
        275                 280                 285             


His Lys Gln Glu Glu Leu Ile Ile Lys Ala Lys Glu Trp Asn Ser Ala 
    290                 295                 300                 


Val Glu Lys Leu Lys Ser Glu Ala Leu Arg Ile Leu Leu Ser Lys Asp 
305                 310                 315                 320 


Tyr Val Glu Lys Glu His Leu Gln Leu Ser His Gln Lys Leu Ser Gln 
                325                 330                 335     


Leu Gln Glu Glu Phe Gly Gln Leu Met Val Glu Arg Asn Thr Trp Leu 
            340                 345                 350         


Lys Lys Ala Asn Glu Phe Phe Asn Ser Ala Asn Lys Ala Phe Asp Val 
        355                 360                 365             


Leu Gly Arg Val Glu Ala Tyr Leu Lys Leu Leu Lys Ser Glu Gly Leu 
    370                 375                 380                 


Ser Leu Ala Val Leu Ala Val Arg His Glu Glu Leu His Arg Lys Ile 
385                 390                 395                 400 


Lys Asp Cys Thr Thr Asp Ala Leu Gln Lys Gly Gln Thr Leu Ile Ser 
                405                 410                 415     


Gln Val Asp Ser Cys Ser Ser Gln Val Ser Gly Ile His Glu Met Met 
            420                 425                 430         


Gly Cys Ile Lys Arg Arg Val Asp His Leu Thr Glu Gln Cys Ser Ala 
        435                 440                 445             


His Lys Glu Tyr Ala Leu Lys Lys Gln Gln Leu Thr Ala Ser Val Glu 
    450                 455                 460                 


Gly Tyr Leu Arg Lys Val Glu Met Ser Ile Gln Lys Ile Ser Pro Val 
465                 470                 475                 480 


Leu Ser Asn Ala Met Asp Val Gly Ser Thr Arg Ser Glu Ser Glu Lys 
                485                 490                 495     


Ile Leu Asn Lys Tyr Leu Glu Leu Asp Ile Gln Ala Lys Glu Thr Ser 
            500                 505                 510         


His Glu Leu Glu Ala Ala Ala Lys Thr Met Met Glu Lys Asn Glu Phe 
        515                 520                 525             


Val Ser Asp Glu Met Val Ser Leu Ser Ser Lys Ala Arg Trp Leu Ala 
    530                 535                 540                 


Glu Glu Leu Asn Leu Phe Gly Gln Ser Ile Asp Tyr Arg Ser Gln Val 
545                 550                 555                 560 


Leu Gln Thr Tyr Val Ala Phe Leu Lys Ser Ser Glu Glu Val Glu Met 
                565                 570                 575     


Gln Phe Gln Ser Leu Lys Glu Phe Tyr Glu Thr Glu Ile Pro Gln Lys 
            580                 585                 590         


Glu Gln Asp Asp Ala Lys Ala Lys His Cys Ser Asp Ser Ala Glu Lys 
        595                 600                 605             


Gln Trp Gln Leu Phe Leu Lys Lys Ser Phe Ile Thr Gln Asp Leu Gly 
    610                 615                 620                 


Leu Glu Phe Leu Asn Leu Ile Asn Met Ala Lys Glu Asn Glu Ile Leu 
625                 630                 635                 640 


Asp Val Lys Asn Glu Val Tyr Leu Met Lys Asn Thr Met Glu Asn Gln 
                645                 650                 655     


Lys Ala Glu Arg Glu Glu Leu Ser Leu Leu Arg Leu Ala Trp Gln Leu 
            660                 665                 670         


Lys Ala Thr Glu Ser Lys Pro Gly Lys Gln Gln Trp Ala Ala Phe Lys 
        675                 680                 685             


Glu Gln Leu Lys Lys Thr Ser His Asn Leu Lys Leu Leu Gln Glu Ala 
    690                 695                 700                 


Leu Met Pro Val Ser Ala Leu Asp Leu Gly Gly Ser Leu Gln Phe Ile 
705                 710                 715                 720 


Leu Asp Leu Arg Gln Lys Trp Asn Asp Met Lys Pro Gln Phe Gln Gln 
                725                 730                 735     


Leu Asn Asp Glu Val Gln Tyr Ile Met Lys Glu Ser Glu Glu Leu Thr 
            740                 745                 750         


Gly Arg Gly Ala Pro Val Lys Glu Lys Ser Gln Gln Leu Lys Asp Leu 
        755                 760                 765             


Ile His Phe His Gln Lys Gln Lys Glu Arg Ile Gln Asp Tyr Glu Asp 
    770                 775                 780                 


Ile Leu Tyr Lys Val Val Gln Phe His Gln Val Lys Glu Glu Leu Gly 
785                 790                 795                 800 


Arg Leu Ile Lys Ser Arg Glu Leu Glu Phe Val Glu Gln Pro Lys Glu 
                805                 810                 815     


Leu Gly Asp Ala His Asp Val Gln Ile His Leu Arg Cys Ser Gln Glu 
            820                 825                 830         


Lys Gln Ala Arg Val Asp His Leu His Arg Leu Ala Leu Ser Leu Gly 
        835                 840                 845             


Val Asp Ile Ile Ser Ser Val Gln Arg Pro His Cys Ser Asn Val Ser 
    850                 855                 860                 


Ala Lys Asn Leu Gln Gln Gln Leu Glu Leu Leu Glu Glu Asp Ser Met 
865                 870                 875                 880 


Lys Trp Arg Ala Lys Ala Glu Glu Tyr Gly Arg Thr Leu Ser Arg Ser 
                885                 890                 895     


Val Glu Tyr Cys Ala Met Arg Asp Glu Ile Asn Glu Leu Lys Asp Ser 
            900                 905                 910         


Phe Lys Asp Ile Lys Lys Lys Phe Asn Asn Leu Lys Phe Asn Tyr Thr 
        915                 920                 925             


Lys Lys Asn Glu Lys Ser Arg Asn Leu Lys Ala Leu Lys Tyr Gln Ile 
    930                 935                 940                 


Gln Gln Val Asp Met Tyr Ala Glu Lys Met Gln Ala Leu Lys Arg Lys 
945                 950                 955                 960 


Met Glu Lys Val Ser Asn Lys Thr Ser Asp Ser Phe Leu Asn Tyr Pro 
                965                 970                 975     


Ser Asp Lys Val Asn Val Leu Leu Glu Val Met Lys Asp Leu Gln Lys 
            980                 985                 990         


His Val Asp Asp Phe Asp Lys Val  Val Thr Asp Tyr Lys  Lys Asn Leu 
        995                 1000                 1005             


Asp Leu  Thr Glu His Phe Gln  Glu Val Ile Glu Glu  Cys His Phe 
    1010                 1015                 1020             


Trp Tyr  Glu Asp Ala Ser Ala  Thr Val Val Arg Val  Gly Lys Tyr 
    1025                 1030                 1035             


Ser Thr  Glu Cys Lys Thr Lys  Glu Ala Val Lys Ile  Leu His Gln 
    1040                 1045                 1050             


Gln Phe  Asn Lys Phe Ile Ala  Pro Ser Val Pro Gln  Gln Glu Glu 
    1055                 1060                 1065             


Arg Ile  Gln Glu Ala Thr Asp  Leu Ala Gln His Leu  Tyr Gly Leu 
    1070                 1075                 1080             


Glu Glu  Gly Gln Lys Tyr Ile  Glu Lys Ile Val Thr  Lys His Lys 
    1085                 1090                 1095             


Glu Val  Leu Glu Ser Val Thr  Glu Leu Cys Glu Ser  Leu Thr Glu 
    1100                 1105                 1110             


Leu Glu  Glu Lys Leu Lys Gln  Gly Asp Val Leu Lys  Met Asn Pro 
    1115                 1120                 1125             


Asn Leu  Glu Asp Phe His Tyr  Asp Tyr Ile Asp Leu  Leu Lys Glu 
    1130                 1135                 1140             


Pro Ala  Lys Asn Lys Gln Thr  Ile Phe Asn Glu Glu  Arg Asn Lys 
    1145                 1150                 1155             


Gly Gln  Val Gln Val Ala Asp  Leu Leu Gly Ile Asn  Gly Thr Gly 
    1160                 1165                 1170             


Glu Glu  Arg Leu Pro Gln Asp  Leu Lys Val Ser Thr  Asp Lys Glu 
    1175                 1180                 1185             


Gly Gly  Val Gln Asp Leu Leu  Leu Pro Glu Asp Met  Leu Ser Gly 
    1190                 1195                 1200             


Glu Glu  Tyr Glu Cys Val Ser  Pro Asp Asp Ile Ser  Leu Pro Pro 
    1205                 1210                 1215             


Leu Pro  Gly Ser Pro Glu Ser  Pro Leu Ala Pro Ser  Asp Met Glu 
    1220                 1225                 1230             


Val Glu  Glu Pro Val Ser Ser  Ser Leu Ser Leu His  Ile Ser Ser 
    1235                 1240                 1245             


Tyr Gly  Val Gln Ala Gly Thr  Ser Ser Pro Gly Asp  Ala Gln Glu 
    1250                 1255                 1260             


Ser Val  Leu Pro Pro Pro Val  Ala Phe Ala Asp Ala  Cys Asn Asp 
    1265                 1270                 1275             


Lys Arg  Glu Thr Phe Ser Ser  His Phe Glu Arg Pro  Tyr Leu Gln 
    1280                 1285                 1290             


Phe Lys  Ala Glu Pro Pro Leu  Thr Ser Arg Gly Phe  Val Glu Lys 
    1295                 1300                 1305             


Ser Thr  Ala Leu His Arg Ile  Ser Ala Glu His Pro  Glu Ser Met 
    1310                 1315                 1320             


Met Ser  Glu Val His Glu Arg  Ala Leu Gln Gln His  Pro Gln Ala 
    1325                 1330                 1335             


Gln Gly  Gly Leu Leu Glu Thr  Arg Glu Lys Met His  Ala Asp Asn 
    1340                 1345                 1350             


Asn Phe  Thr Lys Thr Gln Asp  Arg Leu His Ala Ser  Ser Asp Ala 
    1355                 1360                 1365             


Phe Ser  Gly Leu Arg Phe Gln  Ser Gly Thr Ser Arg  Gly Tyr Gln 
    1370                 1375                 1380             


Arg Gln  Met Val Pro Arg Glu  Glu Ile Lys Ser Thr  Ser Ala Lys 
    1385                 1390                 1395             


Ser Ser  Val Val Ser Leu Ala  Asp Gln Ala Pro Asn  Phe Ser Arg 
    1400                 1405                 1410             


Leu Leu  Ser Asn Val Thr Val  Met Glu Gly Ser Pro  Val Thr Leu 
    1415                 1420                 1425             


Glu Val  Glu Val Thr Gly Phe  Pro Glu Pro Thr Leu  Thr Trp Tyr 
    1430                 1435                 1440             


Lys Lys  Gly Gln Lys Leu Ser  Ala Asp Gly His Leu  Gln Val Leu 
    1445                 1450                 1455             


His Lys  Glu Thr Arg His Ser  Val Phe Ile Pro Lys  Val Cys Lys 
    1460                 1465                 1470             


Ala Asp  Ala Gly Leu Tyr Val  Ala Arg Ala Gln Asn  Ser Ser Gly 
    1475                 1480                 1485             


Ala Leu  Ser Ser Asn Val Ile  Leu His Val Thr Gly  Asn Cys Arg 
    1490                 1495                 1500             


Leu Pro  Ile Thr Arg Val Asn  Trp Ile Thr Leu Cys  Val Val Tyr 
    1505                 1510                 1515             


Val Ser  Val Ser Leu Met Tyr  Trp Leu Leu Thr Gln  
    1520                 1525                 1530 


<210>  1671
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC148__Homo_sapiens__NP_001288613

<400>  1671

Met Lys Arg Thr Leu Glu Met Asn Val Phe Val Thr Leu Gln Ile Leu 
1               5                   10                  15      


Val Asp Phe Val Lys Lys Gln Leu Lys Thr Val Phe Glu Arg Leu Arg 
            20                  25                  30          


Leu Glu Gln Gln Arg Ile Glu Asn Asp Leu Ser Asp Trp Ser Ile Lys 
        35                  40                  45              


Ile Leu Asp His Ser Leu Glu Glu Lys Thr Asn Pro Leu Ser Glu Leu 
    50                  55                  60                  


Pro Ile Glu Leu Glu Ser Leu Glu Cys Pro Tyr Pro Asp Leu Lys Ser 
65                  70                  75                  80  


Ser Ile Leu Ser Glu Phe Tyr Lys Phe Thr Gln Lys Tyr Gln Lys Lys 
                85                  90                  95      


Leu Gln Asp Phe Asn Leu Gln Leu Glu Asp Ile Tyr Arg Asn Cys Gln 
            100                 105                 110         


Leu Ser Glu Glu Asp His Trp Ile Tyr Gln Ala Ile Leu Asp Gln Tyr 
        115                 120                 125             


Pro Gly Asp Leu Phe Gly Arg Arg Thr Leu Tyr Leu Asp Met Leu Gln 
    130                 135                 140                 


Arg Tyr Phe Pro His Lys Ser Arg His Asp Leu Val Glu His Glu Lys 
145                 150                 155                 160 


Tyr Cys Asp Gln Tyr Arg Phe Ala Ile Glu Gln Gln Asn Ile Leu Ile 
                165                 170                 175     


Ser Asn Trp Asn Lys Asn Lys Lys Asp Phe Ile Gln Lys Ala Val Leu 
            180                 185                 190         


Thr Leu Thr Glu Ala Cys Ala Thr His Glu Met Glu Ser Met Leu Ala 
        195                 200                 205             


Lys Asp Lys Lys Lys Gln Gln Glu Leu Cys Ala Asp Leu Lys Ala Lys 
    210                 215                 220                 


Val Arg Gln Trp Arg Ala His Gln Glu Glu Val Ala Arg Leu Glu Met 
225                 230                 235                 240 


Glu Ile Ser Ala Arg Arg Arg Glu Lys Glu Glu Glu Lys Glu Lys Leu 
                245                 250                 255     


Trp Lys Lys Lys Glu Leu Leu Gln Arg Ala Glu Lys Lys Lys Lys Ile 
            260                 265                 270         


Lys Lys Tyr Trp Ala Lys Lys Lys Gln Lys Trp Gln Glu Met Glu Met 
        275                 280                 285             


Arg Asp Leu Gln Arg Leu Glu Glu Leu Lys Lys Leu Ile Ala Glu Gln 
    290                 295                 300                 


Ser Leu Lys Asp Arg Glu Arg Val Lys Tyr Arg Gln Glu Leu Leu Glu 
305                 310                 315                 320 


Arg Arg Leu Met Glu Lys Lys Glu Val Ala Leu Gln Glu Ala His Glu 
                325                 330                 335     


Asp Lys Glu Arg Ala Arg Arg Leu Glu Ala Leu Arg Lys Gln Val Ala 
            340                 345                 350         


Val Val Ala Gln Phe Asp Pro Val Arg Met Met Ser Asp Thr Met Ala 
        355                 360                 365             


Ser Lys Ala Arg Met Gly Ile Glu Ile Glu Glu Glu Phe Ile Leu Gln 
    370                 375                 380                 


Lys Pro Leu Phe Thr Leu Asn Thr Tyr Asn Glu Gln Gln Ile Ile Ser 
385                 390                 395                 400 


Asp Pro Arg Leu Arg Phe Glu Leu Ala Leu Arg Glu Ala Gly Leu His 
                405                 410                 415     


Arg Thr Leu Tyr Ala Lys Glu Ile Leu Pro Lys Ile Ser Pro Gln Lys 
            420                 425                 430         


Pro Pro Arg Lys Asp Met Glu Ser Thr Val Phe Lys Ile 
        435                 440                 445 


<210>  1672
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC151__Homo_sapiens__NP_001289382

<400>  1672

Met His Pro Pro Val Ala Pro Cys Lys Lys Leu Arg Cys Pro Pro Thr 
1               5                   10                  15      


Arg Ser Phe Thr Pro Thr Arg Gly Arg Ser Lys Glu Gly Asp Arg Lys 
            20                  25                  30          


Ala Phe Phe Glu Ser Ser Gln Trp Asn Ile Lys Lys Asn Gln Glu Thr 
        35                  40                  45              


Ile Ser Gln Leu Arg Lys Glu Thr Lys Ala Leu Glu Leu Lys Leu Leu 
    50                  55                  60                  


Asp Leu Leu Lys Gly Asp Glu Lys Val Val Gln Ala Val Ile Arg Glu 
65                  70                  75                  80  


Trp Lys Trp Glu Lys Pro Tyr Leu Lys Asn Arg Thr Gly Gln Ala Leu 
                85                  90                  95      


Glu His Leu Asp His Arg Leu Arg Glu Lys Val Lys Gln Gln Asn Ala 
            100                 105                 110         


Leu Arg His Gln Val Val Leu Arg Gln Arg Arg Leu Glu Glu Leu Gln 
        115                 120                 125             


Leu Gln His Ser Leu Arg Leu Leu Glu Met Ala Glu Ala Gln Asn Arg 
    130                 135                 140                 


His Thr Glu Val Ala Lys Thr Met Arg Asn Leu Glu Asn Arg Leu Glu 
145                 150                 155                 160 


Lys Ala Gln Met Lys Ala Gln Glu Ala Glu His Ile Thr Ser Val Tyr 
                165                 170                 175     


Leu Gln Leu Lys Ala Tyr Leu Met Asp Glu Ser Leu Asn Leu Glu Asn 
            180                 185                 190         


Arg Leu Asp Ser Met Glu Ala Glu Val Val Arg Thr Lys His Glu Leu 
        195                 200                 205             


Glu Ala Leu His Val Val Asn Gln Glu Ala Leu Asn Ala Arg Asp Ile 
    210                 215                 220                 


Ala Lys Asn Gln Leu Gln Tyr Leu Glu Glu Thr Leu Val Arg Glu Arg 
225                 230                 235                 240 


Lys Lys Arg Glu Arg Tyr Ile Ser Glu Cys Lys Lys Arg Ala Glu Glu 
                245                 250                 255     


Lys Lys Leu Glu Asn Glu Arg Met Glu Arg Lys Thr His Arg Glu His 
            260                 265                 270         


Leu Leu Leu Gln Ser Asp Asp Thr Ile Gln Asp Ser Leu His Ala Lys 
        275                 280                 285             


Glu Glu Glu Leu Arg Gln Arg Trp Ser Met Tyr Gln Met Glu Val Ile 
    290                 295                 300                 


Phe Gly Lys Val Lys Asp Ala Thr Gly Thr Asp Glu Thr His Ser Leu 
305                 310                 315                 320 


Val Arg Arg Phe Leu Ala Gln Gly Asp Thr Phe Ala Gln Leu Glu Thr 
                325                 330                 335     


Leu Lys Ser Glu Asn Glu Gln Thr Leu Val Arg Leu Lys Gln Glu Lys 
            340                 345                 350         


Gln Gln Leu Gln Arg Glu Leu Glu Asp Leu Lys Tyr Ser Gly Glu Ala 
        355                 360                 365             


Thr Leu Val Ser Gln Gln Lys Leu Gln Ala Glu Ala Gln Glu Arg Leu 
    370                 375                 380                 


Lys Lys Glu Glu Arg Arg His Ala Glu Ala Lys Asp Gln Leu Glu Arg 
385                 390                 395                 400 


Ala Leu Arg Ala Met Gln Val Ala Lys Asp Ser Leu Glu His Leu Ala 
                405                 410                 415     


Ser Lys Leu Ile His Ile Thr Val Glu Asp Gly Arg Phe Ala Gly Lys 
            420                 425                 430         


Glu Leu Asp Pro Gln Ala Asp Asn Tyr Val Pro Asn Leu Leu Gly Leu 
        435                 440                 445             


Val Glu Glu Lys Leu Leu Lys Leu Gln Ala Gln Leu Gln Gly His Asp 
    450                 455                 460                 


Val Gln Glu Met Leu Cys His Ile Ala Asn Arg Glu Phe Leu Ala Ser 
465                 470                 475                 480 


Leu Glu Gly Arg Leu Pro Glu Tyr Asn Thr Arg Ile Ala Leu Pro Leu 
                485                 490                 495     


Ala Thr Ser Lys Asp Lys Phe Phe Asp Glu Glu Ser Glu Glu Glu Asp 
            500                 505                 510         


Asn Glu Val Val Thr Arg Ala Ser Leu Lys Ile Arg Ser Gln Lys Leu 
        515                 520                 525             


Ile Glu Ser His Lys Lys His Arg Arg Ser Arg Arg Ser 
    530                 535                 540     


<210>  1673
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC167__Homo_sapiens__NP_612502

<400>  1673

Met Thr Lys Lys Lys Arg Glu Asn Leu Gly Val Ala Leu Glu Ile Asp 
1               5                   10                  15      


Gly Leu Glu Glu Lys Leu Ser Gln Cys Arg Arg Asp Leu Glu Ala Val 
            20                  25                  30          


Asn Ser Arg Leu His Ser Arg Glu Leu Ser Pro Glu Ala Arg Arg Ser 
        35                  40                  45              


Leu Glu Lys Glu Lys Asn Ser Leu Met Asn Lys Ala Ser Asn Tyr Glu 
    50                  55                  60                  


Lys Glu Leu Lys Phe Leu Arg Gln Glu Asn Arg Lys Asn Met Leu Leu 
65                  70                  75                  80  


Ser Val Ala Ile Phe Ile Leu Leu Thr Leu Val Tyr Ala Tyr Trp Thr 
                85                  90                  95      


Met 
    


<210>  1674
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC169-SOHLH2__Homo_sapiens__NP_001185839

<400>  1674

Met Glu Thr Leu Gln Glu Ser Leu Asn Thr Leu Leu Lys Gln Leu Glu 
1               5                   10                  15      


Glu Glu Lys Lys Thr Leu Glu Ser Gln Val Lys Tyr Tyr Ala Leu Lys 
            20                  25                  30          


Leu Glu Gln Glu Ser Lys Ala Tyr Gln Lys Ile Asn Asn Glu Arg Arg 
        35                  40                  45              


Thr Tyr Leu Ala Glu Met Ser Gln Gly Ser Gly Leu His Gln Val Ser 
    50                  55                  60                  


Lys Arg Gln Gln Val Asp Gln Leu Pro Arg Met Gln Glu Asn Leu Val 
65                  70                  75                  80  


Lys Thr Leu Leu Leu Lys Glu Glu Leu Asp Pro Leu Lys Ala Lys Ile 
                85                  90                  95      


Asp Ile Leu Leu Val Gly Asp Val Thr Val Gly Tyr Leu Ala Asp Thr 
            100                 105                 110         


Val Gln Lys Leu Phe Ala Asn Ile Ala Glu Val Thr Ile Thr Ile Ser 
        115                 120                 125             


Asp Thr Lys Glu Ala Ala Ala Leu Leu Asp Asp Cys Ile Phe Asn Met 
    130                 135                 140                 


Val Leu Leu Lys Val Pro Ser Ser Leu Ser Ala Glu Glu Leu Glu Ala 
145                 150                 155                 160 


Ile Lys Leu Ile Arg Phe Gly Lys Lys Lys Asn Thr His Ser Leu Phe 
                165                 170                 175     


Val Phe Ile Ile Pro Glu Asn Phe Lys Gly Cys Ile Ser Gly His Gly 
            180                 185                 190         


Met Asp Ile Ala Leu Thr Glu Pro Leu Thr Met Glu Lys Met Ser Asn 
        195                 200                 205             


Val Val Lys Tyr Trp Thr Thr Cys Pro Ser Asn Thr Val Lys Thr Glu 
    210                 215                 220                 


Asn Ala Thr Gly Pro Glu Glu Leu Gly Leu Pro Leu Gln Arg Ser Tyr 
225                 230                 235                 240 


Ser Glu His Leu Gly Tyr Phe Pro Thr Asp Leu Phe Ala Cys Ser Glu 
                245                 250                 255     


Ser Leu Arg Asn Gly Asn Gly Leu Glu Leu Asn Ala Ser Leu Ser Glu 
            260                 265                 270         


Phe Glu Lys Asn Lys Lys Ile Ser Leu Leu His Ser Ser Lys Glu Lys 
        275                 280                 285             


Leu Arg Arg Glu Arg Ile Lys Tyr Cys Cys Glu Gln Leu Arg Thr Leu 
    290                 295                 300                 


Leu Pro Tyr Val Lys Gly Arg Lys Asn Asp Ala Ala Ser Val Leu Glu 
305                 310                 315                 320 


Ala Thr Val Asp Tyr Val Lys Tyr Ile Arg Glu Lys Ile Ser Pro Ala 
                325                 330                 335     


Val Met Ala Gln Ile Thr Glu Ala Leu Gln Ser Asn Met Arg Phe Cys 
            340                 345                 350         


Lys Lys Gln Gln Thr Pro Ile Glu Leu Ser Leu Pro Gly Thr Val Met 
        355                 360                 365             


Ala Gln Arg Glu Asn Ser Val Met Ser Thr Tyr Ser Pro Glu Arg Gly 
    370                 375                 380                 


Leu Gln Phe Leu Thr Asn Thr Cys Trp Asn Gly Cys Ser Thr Pro Asp 
385                 390                 395                 400 


Ala Glu Ser Ser Leu Asp Glu Ala Val Arg Val Pro Ser Ser Ser Ala 
                405                 410                 415     


Ser Glu Asn Ala Ile Gly Asp Pro Tyr Lys Thr His Ile Ser Ser Ala 
            420                 425                 430         


Ala Leu Ser Leu Asn Ser Leu His Thr Val Arg Tyr Tyr Ser Lys Val 
        435                 440                 445             


Thr Pro Ser Tyr Asp Ala Thr Ala Val Thr Asn Gln Asn Ile Ser Ile 
    450                 455                 460                 


His Leu Pro Ser Ala Met Pro Pro Val Ser Lys Leu Leu Pro Arg His 
465                 470                 475                 480 


Cys Thr Ser Gly Leu Gly Gln Thr Cys Thr Thr His Pro Asn Cys Leu 
                485                 490                 495     


Gln Gln Phe Trp Ala Tyr 
            500         


<210>  1675
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC170__Homo_sapiens__NP_079335

<400>  1675

Met Ser Leu Asp Cys Thr Ser His Ile Ala Leu Gly Ala Ala Ser Pro 
1               5                   10                  15      


Ala Pro Glu Glu Thr Tyr Asp His Leu Ser Glu Val Pro Val Thr Arg 
            20                  25                  30          


Glu Gln Leu Asn His Tyr Arg Asn Val Ala Gln Asn Ala Arg Ser Glu 
        35                  40                  45              


Leu Ala Ala Thr Leu Val Lys Phe Glu Cys Ala Gln Ser Glu Leu Gln 
    50                  55                  60                  


Asp Leu Arg Ser Lys Met Leu Ser Lys Glu Val Ser Cys Gln Glu Leu 
65                  70                  75                  80  


Lys Ala Glu Met Glu Ser Tyr Lys Glu Asn Asn Ala Arg Lys Ser Ser 
                85                  90                  95      


Leu Leu Thr Ser Leu Arg Asp Arg Val Gln Glu Leu Glu Glu Glu Ser 
            100                 105                 110         


Ala Ala Leu Ser Thr Ser Lys Ile Arg Thr Glu Ile Thr Ala His Ala 
        115                 120                 125             


Ala Ile Lys Glu Asn Gln Glu Leu Lys Lys Lys Val Val Glu Leu Asn 
    130                 135                 140                 


Glu Lys Leu Gln Lys Cys Ser Lys Glu Asn Glu Glu Asn Lys Lys Gln 
145                 150                 155                 160 


Val Ser Lys Asn Cys Arg Lys His Glu Glu Phe Leu Thr Gln Leu Arg 
                165                 170                 175     


Asp Cys Leu Asp Pro Asp Glu Arg Asn Asp Lys Ala Ser Asp Glu Asp 
            180                 185                 190         


Leu Ile Leu Lys Leu Arg Asp Leu Arg Lys Glu Asn Glu Phe Val Lys 
        195                 200                 205             


Gly Gln Ile Val Ile Leu Glu Glu Thr Ile Asn Val His Glu Met Glu 
    210                 215                 220                 


Ala Lys Ala Ser Arg Glu Thr Ile Met Arg Leu Ala Ser Glu Val Asn 
225                 230                 235                 240 


Arg Glu Gln Lys Lys Ala Ala Ser Cys Thr Glu Glu Lys Glu Lys Leu 
                245                 250                 255     


Asn Gln Asp Leu Leu Ser Ala Val Glu Ala Lys Glu Ala Leu Glu Arg 
            260                 265                 270         


Glu Val Lys Ile Phe Gln Glu Arg Leu Leu Ala Gly Gln Gln Val Trp 
        275                 280                 285             


Asp Ala Ser Lys Gln Glu Val Ser Leu Leu Lys Lys Ser Ser Ser Glu 
    290                 295                 300                 


Leu Glu Lys Ser Leu Lys Ala Ser Gln Asp Ala Val Thr Thr Ser Gln 
305                 310                 315                 320 


Ser Gln Tyr Phe Ser Phe Arg Glu Lys Ile Ala Ala Leu Leu Arg Gly 
                325                 330                 335     


Arg Leu Ser Met Thr Gly Ser Thr Glu Asp Thr Ile Leu Glu Lys Ile 
            340                 345                 350         


Arg Glu Met Asp Ser Arg Glu Glu Ser Arg Asp Arg Met Val Ser Gln 
        355                 360                 365             


Leu Glu Ala Gln Ile Ser Glu Leu Val Glu Gln Leu Gly Lys Glu Ser 
    370                 375                 380                 


Gly Phe His Gln Lys Ala Leu Gln Arg Ala Gln Lys Ala Glu Asn Met 
385                 390                 395                 400 


Leu Glu Thr Leu Gln Gly Gln Leu Thr His Leu Glu Ala Glu Leu Val 
                405                 410                 415     


Ser Gly Gly Val Leu Arg Asp Asn Leu Asn Phe Glu Lys Gln Lys Tyr 
            420                 425                 430         


Leu Lys Phe Leu Asp Gln Leu Ser Gln Lys Met Lys Leu Asp Gln Met 
        435                 440                 445             


Ala Ala Glu Leu Gly Phe Asp Met Arg Leu Asp Val Val Leu Ala Arg 
    450                 455                 460                 


Thr Glu Gln Leu Val Arg Leu Glu Ser Asn Ala Val Ile Glu Asn Lys 
465                 470                 475                 480 


Thr Ile Ala His Asn Leu Gln Arg Lys Leu Lys Thr Gln Lys Glu Arg 
                485                 490                 495     


Leu Glu Ser Lys Glu Leu His Met Ser Leu Leu Arg Gln Lys Ile Ala 
            500                 505                 510         


Gln Leu Glu Glu Glu Lys Gln Ala Arg Thr Ala Leu Val Val Glu Arg 
        515                 520                 525             


Asp Asn Ala His Leu Thr Ile Arg Asn Leu Gln Lys Lys Val Glu Arg 
    530                 535                 540                 


Leu Gln Lys Glu Leu Asn Thr Cys Arg Asp Leu His Thr Glu Leu Lys 
545                 550                 555                 560 


Ala Lys Leu Ala Asp Thr Asn Glu Leu Lys Ile Lys Thr Leu Glu Gln 
                565                 570                 575     


Thr Lys Ala Ile Glu Asp Leu Asn Lys Ser Arg Asp Gln Leu Glu Lys 
            580                 585                 590         


Met Lys Glu Lys Ala Glu Lys Lys Leu Met Ser Val Lys Ser Glu Leu 
        595                 600                 605             


Asp Thr Thr Glu His Glu Ala Lys Glu Asn Lys Glu Arg Ala Arg Asn 
    610                 615                 620                 


Met Ile Glu Val Val Thr Ser Glu Met Lys Thr Leu Lys Lys Ser Leu 
625                 630                 635                 640 


Glu Glu Ala Glu Lys Arg Glu Lys Gln Leu Ala Asp Phe Arg Glu Val 
                645                 650                 655     


Val Ser Gln Met Leu Gly Leu Asn Val Thr Ser Leu Ala Leu Pro Asp 
            660                 665                 670         


Tyr Glu Ile Ile Lys Cys Leu Glu Arg Leu Val His Ser His Gln His 
        675                 680                 685             


His Phe Val Thr Cys Ala Cys Leu Lys Asp Val Thr Thr Gly Gln Glu 
    690                 695                 700                 


Arg His Pro Gln Gly His Leu Gln Leu Leu His 
705                 710                 715 


<210>  1676
<211>  1326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC171__Homo_sapiens__NP_775821

<400>  1676

Met Asn Leu Asn Thr Ser Ser Asn Thr Gly Asp Thr Gln Arg Leu Lys 
1               5                   10                  15      


Ile Ala Ser Leu Asp Val Lys Gln Ile Leu Lys Asn Glu Thr Glu Leu 
            20                  25                  30          


Asp Ile Thr Asp Asn Leu Arg Lys Lys Leu His Trp Ala Lys Lys Glu 
        35                  40                  45              


Lys Leu Glu Ile Thr Thr Lys His Asn Ala Glu Leu Ala Ser Tyr Glu 
    50                  55                  60                  


Ser Gln Ile Ala Lys Leu Arg Ser Glu Val Glu Lys Gly Glu Ala Leu 
65                  70                  75                  80  


Arg Gln Ser Leu Glu Tyr Asp Leu Ala Val Ala Arg Lys Glu Ala Gly 
                85                  90                  95      


Leu Gly Arg Arg Ala Ala Glu Glu Arg Leu Ala Glu Ala His Arg Ile 
            100                 105                 110         


Gln Glu Lys Leu Cys Ala Gln Asn Ser Glu Leu Gln Ala Lys Thr Asn 
        115                 120                 125             


Glu Thr Glu Lys Ala Phe Gln Thr Ser Gln Gln Lys Trp Lys Glu Glu 
    130                 135                 140                 


Cys Arg Arg Phe Glu His Asp Leu Glu Glu Arg Asp Asn Met Ile Gln 
145                 150                 155                 160 


Asn Cys Asn Arg Glu Tyr Asp Leu Leu Met Lys Glu Lys Ser Arg Leu 
                165                 170                 175     


Glu Lys Thr Leu Gln Glu Ala Leu Glu Lys His Gln Arg Glu Lys Asn 
            180                 185                 190         


Glu Met Glu Ser His Ile Arg Glu Thr Ala Leu Glu Glu Phe Arg Leu 
        195                 200                 205             


Gln Glu Glu Gln Trp Glu Ala Glu Arg Arg Glu Leu Gln Phe Ile Val 
    210                 215                 220                 


Gln Glu Gln Asp Thr Ala Val Gln Asn Met His Lys Lys Val Glu Lys 
225                 230                 235                 240 


Leu Glu Thr Glu His Met Asp Cys Ser Asp Leu Leu Arg Arg Gln Thr 
                245                 250                 255     


Ser Glu Leu Glu Phe Ser Thr Gln Arg Glu Glu Arg Leu Arg Lys Glu 
            260                 265                 270         


Phe Glu Ala Thr Thr Leu Arg Val Arg Lys Leu Glu Glu Asn Ile Glu 
        275                 280                 285             


Ala Glu Arg Ala Ala His Leu Glu Ser Lys Phe Asn Ser Glu Ile Ile 
    290                 295                 300                 


Gln Leu Arg Ile Arg Asp Leu Glu Gly Ala Leu Gln Val Glu Lys Ala 
305                 310                 315                 320 


Ser Gln Ala Glu Ala Val Ala Asp Leu Glu Ile Ile Lys Asn Glu Phe 
                325                 330                 335     


Lys Glu Val Glu Ser Ala Tyr Glu Arg Glu Lys His Asn Ala Gln Glu 
            340                 345                 350         


Ser Phe Ala Lys Leu Asn Leu Leu Glu Lys Glu Tyr Phe Ser Lys Asn 
        355                 360                 365             


Lys Lys Leu Asn Glu Asp Ile Glu Glu Gln Lys Lys Val Ile Ile Asp 
    370                 375                 380                 


Leu Ser Lys Arg Leu Gln Tyr Asn Glu Lys Ser Cys Ser Glu Leu Gln 
385                 390                 395                 400 


Glu Glu Leu Val Met Ala Lys Lys His Gln Ala Phe Leu Val Glu Thr 
                405                 410                 415     


Cys Glu Asn Asn Val Lys Glu Leu Glu Ser Ile Leu Asp Ser Phe Thr 
            420                 425                 430         


Val Ser Gly Gln Trp Thr Ser Gly Ile His Lys Asp Lys Asp Lys Pro 
        435                 440                 445             


Pro Ser Phe Ser Val Val Leu Glu Arg Leu Arg Arg Thr Leu Thr Asp 
    450                 455                 460                 


Tyr Gln Asn Lys Leu Glu Asp Ala Ser Asn Glu Glu Lys Ala Cys Asn 
465                 470                 475                 480 


Glu Leu Asp Ser Thr Lys Gln Lys Ile Asp Ser His Thr Lys Asn Ile 
                485                 490                 495     


Lys Glu Leu Gln Asp Lys Leu Ala Asp Val Asn Lys Glu Leu Ser His 
            500                 505                 510         


Leu His Thr Lys Cys Ala Asp Arg Glu Ala Leu Ile Ser Thr Leu Lys 
        515                 520                 525             


Val Glu Leu Gln Asn Val Leu His Cys Trp Glu Lys Glu Lys Ala Gln 
    530                 535                 540                 


Ala Ala Gln Ser Glu Ser Glu Leu Gln Lys Leu Ser Gln Ala Phe His 
545                 550                 555                 560 


Lys Asp Ala Glu Glu Lys Leu Thr Phe Leu His Thr Leu Tyr Gln His 
                565                 570                 575     


Leu Val Ala Gly Cys Val Leu Ile Lys Gln Pro Glu Gly Met Leu Asp 
            580                 585                 590         


Lys Phe Ser Trp Ser Glu Leu Cys Ala Val Leu Gln Glu Asn Val Asp 
        595                 600                 605             


Ala Leu Ile Ala Asp Leu Asn Arg Ala Asn Glu Lys Ile Arg His Leu 
    610                 615                 620                 


Glu Tyr Ile Cys Lys Asn Lys Ser Asp Thr Met Arg Glu Leu Gln Gln 
625                 630                 635                 640 


Thr Gln Glu Asp Thr Phe Thr Lys Val Ala Glu Gln Ile Lys Ala Gln 
                645                 650                 655     


Glu Ser Cys Trp His Arg Gln Lys Lys Glu Leu Glu Leu Gln Tyr Ser 
            660                 665                 670         


Glu Leu Phe Leu Glu Val Gln Lys Arg Ala Gln Lys Phe Gln Glu Ile 
        675                 680                 685             


Ala Glu Lys Asn Met Glu Lys Leu Asn His Ile Glu Lys Ser His Glu 
    690                 695                 700                 


Gln Leu Val Leu Glu Asn Ser His Phe Lys Lys Leu Leu Ser Gln Thr 
705                 710                 715                 720 


Gln Arg Glu Gln Met Ser Leu Leu Ala Ala Cys Ala Leu Met Ala Gly 
                725                 730                 735     


Ala Leu Tyr Pro Leu Tyr Ser Arg Ser Cys Ala Leu Ser Thr Gln Arg 
            740                 745                 750         


Asp Phe Leu Gln Glu Gln Val Asn Thr Phe Glu Leu Phe Lys Leu Glu 
        755                 760                 765             


Ile Arg Thr Leu Ala Gln Ala Leu Ser Thr Val Glu Glu Lys Lys Gln 
    770                 775                 780                 


Glu Glu Ala Lys Met Lys Lys Lys Thr Phe Lys Gly Leu Ile Arg Ile 
785                 790                 795                 800 


Phe Arg Lys Gly Val Ile Ala Val Leu Ala Ala Asn Arg Leu Lys Ile 
                805                 810                 815     


Leu Gly Gln Ser Cys Ala Ser Leu Phe Thr Trp Met Glu Ser Phe Lys 
            820                 825                 830         


Glu Gly Ile Gly Met Leu Val Cys Thr Gly Glu Pro Gln Asp Lys His 
        835                 840                 845             


Lys Phe Pro Lys His Gln Lys Glu Gln Leu Arg Cys Leu Gln Ala Leu 
    850                 855                 860                 


Ser Trp Leu Thr Ser Ser Asp Leu Leu Ala Ala Ile Ile Ser Ser Met 
865                 870                 875                 880 


Ala Glu Leu Gln Asp Val Ile Gly Lys Ala Asp Pro Asn Ser Arg Ile 
                885                 890                 895     


Cys Gly His Leu Leu Ile Gly Ala Ala Lys Asn Ser Phe Ala Lys Leu 
            900                 905                 910         


Met Asp Lys Ile Ser Leu Val Met Glu Cys Ile Pro Leu His Ser Ser 
        915                 920                 925             


Arg Ser Ile Thr Tyr Val Glu Lys Asp Ser Leu Val Gln Arg Leu Ala 
    930                 935                 940                 


His Gly Leu His Lys Val Asn Thr Leu Ala Leu Lys Tyr Gly Leu Arg 
945                 950                 955                 960 


Gly His Val Pro Ile Thr Lys Ser Thr Ala Ser Leu Gln Lys Gln Ile 
                965                 970                 975     


Leu Gly Phe Thr Gln Arg Leu His Ala Ala Glu Val Glu Arg Arg Ser 
            980                 985                 990         


Leu Arg Leu Glu Val Thr Glu Phe  Lys Arg Ser Val Asn  Glu Met Lys 
        995                 1000                 1005             


Lys Glu  Leu Asp Lys Ala Gln  Gly Leu Gln Met Gln  Leu Asn Glu 
    1010                 1015                 1020             


Phe Lys  Gln Ser Lys Leu Ile  Thr His Glu Lys Phe  Glu Ser Ala 
    1025                 1030                 1035             


Cys Glu  Glu Leu Asn Asn Ala  Leu Leu Arg Glu Glu  Gln Ala Gln 
    1040                 1045                 1050             


Met Leu  Leu Asn Glu Gln Ala  Gln Gln Leu Gln Glu  Leu Asn Tyr 
    1055                 1060                 1065             


Lys Leu  Glu Leu His Ser Ser  Glu Glu Ala Asp Lys  Asn Gln Thr 
    1070                 1075                 1080             


Leu Gly  Glu Ala Val Lys Ser  Leu Ser Glu Ala Lys  Met Glu Leu 
    1085                 1090                 1095             


Arg Arg  Lys Asp Gln Ser Leu  Arg Gln Leu Asn Arg  His Leu Thr 
    1100                 1105                 1110             


Gln Leu  Glu Gln Asp Lys Arg  Arg Leu Glu Glu Asn  Ile His Asp 
    1115                 1120                 1125             


Ala Glu  Ser Ala Leu Arg Met  Ala Ala Lys Asp Lys  Glu Cys Val 
    1130                 1135                 1140             


Ala Asn  His Met Arg Ala Val  Glu Asn Thr Leu His  Lys Val Arg 
    1145                 1150                 1155             


Asp Gln  Ile Ser Leu Ser Trp  Ser Ala Ala Ser Arg  Asn Asp Phe 
    1160                 1165                 1170             


Thr Leu  Gln Leu Pro Lys Leu  His Leu Glu Thr Phe  Ala Met Glu 
    1175                 1180                 1185             


Gly Leu  Lys Gly Gly Pro Glu  Val Val Ala Cys Gln  Ala Met Ile 
    1190                 1195                 1200             


Lys Ser  Phe Met Asp Val Tyr  Gln Leu Ala Ser Thr  Arg Ile Met 
    1205                 1210                 1215             


Thr Leu  Glu Lys Glu Met Thr  Ser His Arg Ser His  Ile Ala Ala 
    1220                 1225                 1230             


Leu Lys  Ser Glu Leu His Thr  Ala Cys Leu Arg Glu  Asn Ala Ser 
    1235                 1240                 1245             


Leu Gln  Ser Ile Gly Ser Arg  Asp His Ser Asn Leu  Ser Ile Pro 
    1250                 1255                 1260             


Ser Arg  Ala Pro Leu Pro Ala  Asp Thr Thr Gly Ile  Gly Asp Phe 
    1265                 1270                 1275             


Leu Pro  Leu Lys Ala Glu Leu  Asp Thr Thr Tyr Thr  Phe Leu Lys 
    1280                 1285                 1290             


Glu Thr  Phe Ile Asn Thr Val  Pro His Ala Leu Thr  Ser Ser His 
    1295                 1300                 1305             


Ser Ser  Pro Val Thr Met Ser  Ala Asn Ala Asn Arg  Pro Thr Gln 
    1310                 1315                 1320             


Ile Gly  Leu 
    1325     


<210>  1677
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC175__Homo_sapiens__NP_001157871

<400>  1677

Met Ala Leu Ser Pro Trp Thr Pro Gly Leu Gly Ala Gly Glu Lys Leu 
1               5                   10                  15      


Val Gln Ala Ala Ala Val Ser Thr Gly Pro Ser Leu Glu Leu Cys Thr 
            20                  25                  30          


Leu Pro Ser Thr Leu Gly Ser Ser Val Ala Val Glu Ala Leu Glu Gln 
        35                  40                  45              


Leu Phe Val Val Glu Gln Ser Leu Gln Ser Asp Tyr Phe Lys Cys Asn 
    50                  55                  60                  


Glu Glu Ala Lys Ile Phe Leu Lys Asp Ile Ala Val Ala Val Lys Lys 
65                  70                  75                  80  


Leu Glu Glu Met Arg Lys Ala Thr Ile Asp Leu Leu Glu Ile Glu Ser 
                85                  90                  95      


Met Glu Leu Asn Lys Leu Tyr Tyr Leu Leu Glu Thr Leu Pro Asn Ser 
            100                 105                 110         


Ile Lys Arg Glu Leu Glu Glu Cys Val Arg Asp Ala Arg Arg Leu Asn 
        115                 120                 125             


Leu Phe Glu Ile Asn Thr Ile Lys Met Arg Ile Thr Arg Thr Glu Asn 
    130                 135                 140                 


Glu Ile Glu Leu Leu Lys Lys Lys Ile Thr Asp Leu Thr Lys Tyr Asn 
145                 150                 155                 160 


Glu Ala Leu Gly Glu Lys Gln Glu Glu Leu Ala Arg Lys His Ala Arg 
                165                 170                 175     


Phe Val Leu Ser Leu Asn Gln Thr Met Glu Lys Lys Ala Thr Thr Thr 
            180                 185                 190         


Val Tyr Ile Asn Glu Thr Tyr Thr Lys Ile Asn Leu Lys Arg Glu Asp 
        195                 200                 205             


Ile Ala Leu Gln Lys Lys Cys Ile Gln Glu Ala Glu Glu Leu Met Glu 
    210                 215                 220                 


Lys Glu Arg Ala Glu Tyr Leu Ile Arg Lys Gln Glu Leu Thr Ala Gln 
225                 230                 235                 240 


Ile Asn Glu Phe Glu Asn Thr Arg Glu Val Lys Arg Met Glu Thr Tyr 
                245                 250                 255     


Gln Lys Lys Lys Glu Leu Asp Lys Leu Gln Thr Lys Met Ser Lys Ile 
            260                 265                 270         


Lys Glu Thr Val Thr Val Ser Ala Ala Val Leu Ser Asp His Asn Leu 
        275                 280                 285             


Glu Ile Ala Arg Leu His Glu Ser Ile Arg Tyr Trp Glu Gln Glu Val 
    290                 295                 300                 


Ser Glu Leu Lys Lys Asp Leu Ala Ile Leu Glu Ala Lys Leu Cys Phe 
305                 310                 315                 320 


Phe Thr Asp Asn Lys Glu Lys Leu Asp Asp Ile Ser Asn Asp Glu Lys 
                325                 330                 335     


Asn Glu Phe Leu Asn Lys Ile Lys Gln Leu Val Glu Thr Leu His Ala 
            340                 345                 350         


Ala Arg Met Glu Tyr Lys Asp Leu Arg Glu Lys Met Lys Thr Leu Ala 
        355                 360                 365             


Arg Gln Tyr Lys Ile Val Leu Ser Glu Glu Glu Lys Ala Phe Leu Gln 
    370                 375                 380                 


Lys Gln Lys Ile His Asp Glu Asn Gln Lys Gln Leu Thr Phe Ile Ser 
385                 390                 395                 400 


Gln Lys Glu Tyr Phe Leu Ser Gln Lys Arg Val Asp Ile Lys Asn Met 
                405                 410                 415     


Glu Glu Gly Leu Ile Thr Leu Gln Glu Leu Gln Gln Ala Thr Lys Thr 
            420                 425                 430         


Val Tyr Gln Gln Gln Ile Lys Ile Leu Ser Ala Asn Leu Glu Arg Glu 
        435                 440                 445             


Ser Gln Arg Cys Val Ile Thr Gln Trp Lys Met Ala Cys Leu Arg Lys 
    450                 455                 460                 


Lys His Ala Arg Trp Thr Ala Lys Ile Lys Ala Glu Ile Gln Ala Ile 
465                 470                 475                 480 


Thr Glu Lys Ile Gln Asn Ala Glu Val Arg Arg Ile Glu Leu Leu Asn 
                485                 490                 495     


Glu Thr Ser Phe Arg Gln Gln Glu Ile Ser Gly Phe Val Ala Gln Ile 
            500                 505                 510         


Glu Lys Leu Thr Thr Glu Leu Lys Glu Glu Glu Lys Ala Phe Val Asn 
        515                 520                 525             


Lys Glu Lys Met Leu Met Lys Glu Leu Ser Lys Tyr Glu Glu Ile Phe 
    530                 535                 540                 


Val Lys Glu Thr Gln Ile Asn Lys Glu Lys Glu Glu Glu Leu Val Glu 
545                 550                 555                 560 


Tyr Leu Pro Gln Leu Gln Val Ala Glu Gln Glu Tyr Lys Glu Lys Arg 
                565                 570                 575     


Arg Lys Leu Glu Glu Leu Ser Asn Ile Ile Thr Ala Gln Arg Gln Glu 
            580                 585                 590         


Glu Asp Leu Leu Asn Asn His Ile Phe Leu Phe Thr Arg Asp Phe Ser 
        595                 600                 605             


Arg Tyr Ile Ser Asn Met Glu Asp Val Lys Gln Glu Leu Gln Gln Leu 
    610                 615                 620                 


Arg Asp Gln Glu Ser Lys Lys Asn Lys Asp His Phe Glu Thr Leu Lys 
625                 630                 635                 640 


Asn Leu Glu Asn Gly Phe Tyr Ile Asn Asp Gln Lys Ala Asp Leu Leu 
                645                 650                 655     


Leu Leu Glu Asn Lys Lys Leu Lys Glu Tyr Ile Leu Tyr Leu Lys Asn 
            660                 665                 670         


Asn Ile Glu Lys Tyr Arg Glu Gly Gln Glu Ala Leu Met His Thr Ser 
        675                 680                 685             


Ser Asp Leu Ser Arg Gln Leu Ile Ala Gln Glu Ala Gln Tyr Lys Asp 
    690                 695                 700                 


Leu Trp Ala Glu Phe Gln Thr Thr Val Lys Ile Leu Val Asp Asn Gly 
705                 710                 715                 720 


Glu Glu Thr Leu Gln Asp Ile Asn Asn Leu Thr Asp Lys Leu Arg Glu 
                725                 730                 735     


Arg Asp Glu Lys Met Gln His Val Ser Thr Trp Leu Arg Gly Ser Leu 
            740                 745                 750         


Glu Gly Leu Arg Leu Leu Val Glu Gln Glu Ser Pro Met Asp Leu Leu 
        755                 760                 765             


Lys Lys Lys Lys His Ile Arg Thr Arg Val His Phe Pro Val Val Lys 
    770                 775                 780                 


Cys Thr Glu Lys Asn Thr Leu Thr Lys 
785                 790             


<210>  1678
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC176__Homo_sapiens__NP_079333

<400>  1678

Met Pro Ser Lys Gly Lys Asp Lys Lys Lys Gly Lys Ser Lys Gly Lys 
1               5                   10                  15      


Asp Thr Lys Lys Leu Ile Lys Thr Asp Glu Ser Val Val Asp Arg Ala 
            20                  25                  30          


Lys Ala Asn Ala Ser Leu Trp Glu Ala Arg Leu Glu Val Thr Glu Leu 
        35                  40                  45              


Ser Arg Ile Lys Tyr Arg Asp Thr Ser Arg Ile Leu Ala Lys Ser Asn 
    50                  55                  60                  


Glu Asp Leu Lys Lys Lys Gln Cys Lys Met Glu Lys Asp Ile Met Ser 
65                  70                  75                  80  


Val Leu Ser Tyr Leu Lys Lys Gln Asp Gln Glu Lys Asp Asn Met Ile 
                85                  90                  95      


Glu Lys Leu Lys Gln Gln Leu Asn Glu Thr Lys Glu Lys Ala Gln Glu 
            100                 105                 110         


Glu Lys Asp Lys Leu Glu Gln Lys Tyr Thr Arg Gln Ile Asn Glu Leu 
        115                 120                 125             


Glu Gly Gln Phe His Gln Lys Ala Lys Glu Ile Gly Met Ile His Thr 
    130                 135                 140                 


Glu Leu Lys Ala Val Arg Gln Phe Gln Lys Arg Lys Ile Gln Val Glu 
145                 150                 155                 160 


Arg Glu Leu Asp Asp Leu Lys Glu Asn Leu Arg Asn Thr Glu Arg Ile 
                165                 170                 175     


His Gln Glu Thr Leu Arg Arg Leu Glu Ser Arg Phe Phe Glu Glu Lys 
            180                 185                 190         


His Arg Leu Glu Gln Glu Ala Glu Lys Lys Ile Ile Met Leu Ala Glu 
        195                 200                 205             


Arg Ala His His Glu Ala Ile Val Gln Leu Asn Asp Ala Gly Arg Asn 
    210                 215                 220                 


Val Phe Lys Glu Asn Asp Tyr Leu Gln Lys Ala Leu Ala Tyr His Leu 
225                 230                 235                 240 


Lys Glu Thr Asp Ala Leu Gln Lys Asn Ser Gln Lys Leu Gln Glu Ser 
                245                 250                 255     


His Thr Leu Leu Leu His Gln Lys Glu Ile Asn Asp Leu Leu Val Lys 
            260                 265                 270         


Glu Lys Ile Met Gln Leu Val Gln Gln Arg Ser Gln Ile Gln Thr Leu 
        275                 280                 285             


Gln Lys Lys Val Val Asn Leu Glu Thr Ala Leu Ser Tyr Met Thr Lys 
    290                 295                 300                 


Glu Phe Glu Ser Glu Val Leu Lys Leu Gln Gln His Ala Met Ile Glu 
305                 310                 315                 320 


Asn Gln Ala Gly Gln Val Glu Ile Asp Lys Leu Gln His Leu Leu Gln 
                325                 330                 335     


Met Lys Asp Arg Glu Met Asn Arg Val Lys Lys Leu Ala Lys Asn Ile 
            340                 345                 350         


Leu Asp Glu Arg Thr Glu Val Glu Arg Phe Phe Leu Asp Ala Leu His 
        355                 360                 365             


Gln Val Lys Gln Gln Ile Leu Ile Ser Arg Lys His Tyr Lys Gln Ile 
    370                 375                 380                 


Ala Gln Ala Ala Phe Asn Leu Lys Met Arg Ala Ala Cys Thr Gly Arg 
385                 390                 395                 400 


Thr Glu Tyr Pro Lys Ile Arg Thr Phe Asp Gly Arg Glu His Ser Thr 
                405                 410                 415     


Asn Ser Val Asn Gln Asp Leu Leu Glu Ala Glu Lys Trp Thr His Ile 
            420                 425                 430         


Glu Gly Asn Val Asp Ile Gly Asp Leu Thr Trp Glu Gln Lys Glu Lys 
        435                 440                 445             


Val Leu Arg Leu Leu Phe Ala Lys Met Asn Gly Cys Pro Ser Arg Lys 
    450                 455                 460                 


Tyr Asn Gln Ser Ser Arg Pro Pro Val Pro Asp Tyr Val Val Ser Asp 
465                 470                 475                 480 


Ser Gly Glu Thr Lys Glu Phe Gly Asp Glu Ser Lys Leu Gln Asp Lys 
                485                 490                 495     


Ile Phe Ile Thr Gln Gln Ile Ala Ile Ser Asp Ser Ser Gly Glu Val 
            500                 505                 510         


Val Leu Pro Thr Ile Pro Lys Glu Pro Gln Glu Ser Asp Thr Gly Thr 
        515                 520                 525             


Phe 
    


<210>  1679
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC178__Homo_sapiens__NP_001098998

<400>  1679

Met Thr Glu Asn Lys Thr Val Ser Ser Ser Ser Thr Arg Asp Asp Gln 
1               5                   10                  15      


Thr Asn Ile Gly Leu Thr Cys Gln Glu Val Lys Ala Leu Arg Glu Lys 
            20                  25                  30          


Ala Trp Ser Arg Thr Asn Glu Gly Asn Ala Met Ser Gln Ser Leu Val 
        35                  40                  45              


Leu Tyr Gly Ala Ser Lys Glu Asn Ser Glu Gly Phe His Glu Ser Lys 
    50                  55                  60                  


Met Thr Asn Thr Glu Gly Val Asn Lys Gly Ile Tyr Phe Ser Tyr Pro 
65                  70                  75                  80  


Cys Arg Arg His Ser Cys Ala Val Val Asn Ile Pro Ala Pro Cys Val 
                85                  90                  95      


Asn Lys Met Ile Ser His Ile Gln Asp Val Glu Ser Lys Ile Gln Glu 
            100                 105                 110         


His Leu Lys Arg Phe Glu Thr Ser Phe Glu Glu Trp Ser Arg Thr Ser 
        115                 120                 125             


Ser Thr Lys Asp Leu Lys Glu Asp Trp Ser Val Thr Thr Pro Val Lys 
    130                 135                 140                 


Glu Val Lys Pro Gly Glu Lys Arg Asp Glu Lys Cys Pro Glu Leu Lys 
145                 150                 155                 160 


Gln Glu Met Glu Thr Leu Leu Ser Glu Ala Ile Arg Leu Ile Lys Ser 
                165                 170                 175     


Leu Glu Thr Asp Arg Ala Asp Ala Glu Glu Ala Leu Lys Gln Gln Arg 
            180                 185                 190         


Ser Arg Lys Asn Met Ile Asn Met Lys Ile Asp Ser Trp Ser Val Trp 
        195                 200                 205             


Lys Leu Gln Glu Leu Pro Leu Ala Val Gln Lys Glu His Glu Ala Tyr 
    210                 215                 220                 


Leu Ser Asp Val Ile Glu Leu Gln Trp His Leu Glu Asp Lys Ala Asn 
225                 230                 235                 240 


Gln Leu Gln His Phe Glu Lys Gln Lys Thr Glu Leu Glu Glu Ala Asn 
                245                 250                 255     


Ala Lys Ile Gln Ala Asp Ile Asp Tyr Met Asn Glu His Gly Pro Leu 
            260                 265                 270         


Leu Asp Ser Lys Gln Asn Gln Glu Leu Gln Asp Leu Lys Asn His Tyr 
        275                 280                 285             


Lys Lys Lys Met Glu Val Met Asp Leu His Arg Lys Val Asn Glu Glu 
    290                 295                 300                 


Leu Glu Glu Ala Leu Glu Ala Cys Glu Asn Ala Arg Leu Lys Ala Gln 
305                 310                 315                 320 


Gln Ile Lys Glu Glu Ile Asp Lys Asp Ile Tyr Gln Asp Glu Lys Thr 
                325                 330                 335     


Ile Glu Ala Tyr Lys Arg Glu Ile Tyr Gln Leu Asn Ser Leu Phe Asp 
            340                 345                 350         


His Tyr Ser Ser Ser Val Ile Asn Val Asn Thr Asn Ile Glu Glu Lys 
        355                 360                 365             


Glu Glu Glu Val Thr Glu Ala Ile Arg Glu Thr Lys Ser Ser Lys Asn 
    370                 375                 380                 


Glu Leu His Ser Leu Ser Lys Met Leu Glu Asp Leu Arg Arg Val Tyr 
385                 390                 395                 400 


Asp Gln Leu Thr Trp Lys Gln Lys Ser His Glu Asn Gln Tyr Leu Glu 
                405                 410                 415     


Ala Val Asn Asp Phe Tyr Ala Ala Lys Lys Thr Trp Asp Ile Glu Leu 
            420                 425                 430         


Ser Asp Val Ala Lys Asp Phe Ser Ala Ile Ser Leu Ala Cys Thr Lys 
        435                 440                 445             


Leu Thr Glu Asp Asn Lys Lys Leu Glu Ile Asp Ile Asn Lys Ile Thr 
    450                 455                 460                 


Val Lys Thr Asn Glu Ser Ile Arg Lys Lys Ser Lys Tyr Glu Ser Glu 
465                 470                 475                 480 


Ile Lys Tyr Leu Thr Ile Met Lys Leu Lys Asn Asp Lys His Leu Lys 
                485                 490                 495     


Asn Ile Tyr Lys Glu Ala Tyr Arg Ile Gly Thr Leu Phe His Leu Thr 
            500                 505                 510         


Lys His Lys Thr Asp Glu Met Glu Asp Lys Ile Ala Glu Val Arg Arg 
        515                 520                 525             


Lys Phe Lys Gly Arg Glu Glu Phe Leu Lys Lys Leu Thr Gln Gly Glu 
    530                 535                 540                 


Val Ala Ala Gly Met Val Leu Gln Lys Lys Leu Tyr Ser Ile Tyr Glu 
545                 550                 555                 560 


Val Gln Ala Leu Glu Arg Lys Glu Leu Ile Lys Asn Arg Ala Ile Cys 
                565                 570                 575     


Ala Met Ser Leu Ala Glu Leu Gln Glu Pro Leu Leu Gln Leu Glu Asp 
            580                 585                 590         


Glu Ala Glu Arg Ile Arg Ser Leu Asp Lys Glu His Ser Val Met Leu 
        595                 600                 605             


Asn Asn Ile Ile Asp Gln Lys Asp Leu Ile Arg Arg Lys Val Gly Lys 
    610                 615                 620                 


Val Lys Lys Lys Leu Arg Lys Lys Gly Lys Lys Thr Leu Asp Ala Leu 
625                 630                 635                 640 


Ile Glu Thr Glu Ser Lys Arg Ser Ala Ile Phe Lys Asp Leu Glu Ala 
                645                 650                 655     


Thr Lys Ser Lys Thr Met Ile Phe Tyr Ala Lys Ile Asn Glu Leu Asn 
            660                 665                 670         


Glu Glu Leu Lys Ala Lys Glu Glu Glu Lys Lys Ser Phe Asp Gln Thr 
        675                 680                 685             


Leu Glu Ile Leu Lys Asn Lys Phe Ile Thr Met Arg Phe Lys Arg Glu 
    690                 695                 700                 


His Ala Gln Thr Val Phe Asp His Tyr Met Gln Glu Lys Lys Asp Cys 
705                 710                 715                 720 


Glu Glu Arg Ile Phe Glu Glu Asp Gln Arg Phe Arg Val Leu Leu Ala 
                725                 730                 735     


Val Arg Gln Lys Thr Leu Gln Asp Thr Gln Lys Ile Ile Ala Asp Ser 
            740                 745                 750         


Leu Glu Glu Asn Leu Arg Leu Ala Gln Glu Tyr Gln Gln Leu Gln Ile 
        755                 760                 765             


Thr Phe Leu Lys Glu Lys Asp Asn Tyr Phe Asn Ile Tyr Asp Lys Gln 
    770                 775                 780                 


Leu Ser Leu Asp Thr Ser Ile Arg Asp Lys Lys Gln Leu Cys Gln Leu 
785                 790                 795                 800 


Gln Arg Arg Met His Thr Leu Trp Gln Glu His Phe Lys Leu Val Val 
                805                 810                 815     


Leu Phe Ser Gln Met Arg Leu Ala Asn Phe Gln Thr Asp Ser Gln Glu 
            820                 825                 830         


Ser Ile Gln Lys Ile Leu Ala Val Gln Glu Glu Ser Ser Asn Leu Met 
        835                 840                 845             


Gln His Ile Leu Gly Phe Phe Gln Thr Leu Thr Asp Gly Thr Cys Glu 
    850                 855                 860                 


Asn Asp Gly 
865         


<210>  1680
<211>  1701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC180__Homo_sapiens__NP_065944

<400>  1680

Met Arg Gly Gly Glu Asn Arg Pro Pro Ala Arg Val Gln Ser Ser Ser 
1               5                   10                  15      


Glu Glu Leu Glu Leu Arg His Gln Ser Leu Asp Ala Phe Pro Gly Arg 
            20                  25                  30          


Arg Leu Pro Gly Arg Gly Ile Gln Pro Ala Ala Lys Met Ser Ser Val 
        35                  40                  45              


Gly Lys Val Thr Gln Val Pro Asn Gly Lys Ala Tyr Gln Gln Ile Phe 
    50                  55                  60                  


Gln Ala Glu Val Gln Leu Val His Ser Leu Ala Ala Thr Arg Lys Arg 
65                  70                  75                  80  


Ala Ala Glu Arg Ser Val Thr Leu Lys Ser Gly Arg Ile Pro Met Met 
                85                  90                  95      


Lys Lys Val Glu Thr Pro Glu Gly Glu Val Met Ser Pro Arg Gln Gln 
            100                 105                 110         


Lys Trp Met His Ser Leu Pro Asn Asp Trp Ile Met Glu Asn Pro Val 
        115                 120                 125             


Leu His Arg Glu Lys Glu Arg Ala Lys Arg Glu Lys Ala Arg Glu Ser 
    130                 135                 140                 


Glu Asn Thr Ile Ala Ala Arg Glu Val Arg Gly Leu Met Asp Thr Ile 
145                 150                 155                 160 


Val Pro Glu Lys Ile Ser Thr Ser Thr Phe Gln Arg Gln Ala Glu His 
                165                 170                 175     


Lys Arg Lys Ser Tyr Glu Ser Ala Leu Ala Ser Phe Gln Glu Glu Ile 
            180                 185                 190         


Ala Gln Val Gly Lys Glu Met Glu Pro Leu Ile Val Asp Thr Gly Gly 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Thr Glu Ser Asp Glu Glu Met Asn Arg Leu 
    210                 215                 220                 


Phe Leu Lys Val Glu Asn Asp Thr Asn Leu Glu Asp Tyr Thr Ile Gln 
225                 230                 235                 240 


Ala Leu Leu Glu Leu Trp Asp Lys Val Ala Gly Arg Leu Leu Leu Arg 
                245                 250                 255     


Lys Gln Glu Ile Lys Glu Leu Asp Glu Ala Leu His Ser Leu Glu Phe 
            260                 265                 270         


Ser Arg Thr Asp Lys Leu Lys Ser Val Leu Lys Lys Tyr Ala Glu Val 
        275                 280                 285             


Ile Glu Lys Thr Ser Tyr Leu Met Arg Pro Glu Val Tyr Arg Leu Ile 
    290                 295                 300                 


Asn Glu Glu Ala Met Val Met Asn Tyr Ala Leu Leu Gly Asn Arg Lys 
305                 310                 315                 320 


Ala Leu Ala Gln Leu Phe Val Asn Leu Met Glu Ser Thr Leu Gln Gln 
                325                 330                 335     


Glu Leu Asp Ser Arg His Arg Trp Gln Gly Leu Val Asp Thr Trp Lys 
            340                 345                 350         


Ala Leu Lys Lys Glu Ala Leu Leu Gln Ser Phe Ser Glu Phe Met Ala 
        355                 360                 365             


Ser Glu Ser Ile His Thr Pro Pro Ala Val Thr Lys Glu Leu Glu Val 
    370                 375                 380                 


Met Leu Lys Thr Gln Asn Val Leu Gln Gln Arg Arg Leu Lys His Leu 
385                 390                 395                 400 


Cys Thr Ile Cys Asp Leu Leu Pro Pro Ser Tyr Ser Lys Thr Gln Leu 
                405                 410                 415     


Thr Glu Trp His Ser Ser Leu Asn Ser Leu Asn Lys Glu Leu Asp Thr 
            420                 425                 430         


Tyr His Val Asp Cys Met Met Arg Ile Arg Leu Leu Tyr Glu Lys Thr 
        435                 440                 445             


Trp Gln Glu Cys Leu Met His Val Gln Asn Cys Lys Lys Gln Leu Leu 
    450                 455                 460                 


Asp Trp Lys Ala Phe Thr Glu Glu Glu Ala Glu Thr Leu Val Asn Gln 
465                 470                 475                 480 


Phe Phe Phe Gln Met Val Gly Ala Leu Gln Gly Lys Val Glu Glu Asp 
                485                 490                 495     


Leu Glu Leu Leu Asp Lys Ser Phe Glu Thr Leu Ala Asp Gln Thr Glu 
            500                 505                 510         


Trp Gln Ser Ser His Leu Phe Lys Tyr Phe Gln Glu Val Val Gln Leu 
        515                 520                 525             


Trp Glu Ala His Gln Ser Glu Leu Leu Val Gln Glu Leu Glu Leu Glu 
    530                 535                 540                 


Lys Arg Met Glu Gln His Arg Gln Lys His Ser Leu Glu Ser Gln Val 
545                 550                 555                 560 


Gln Glu Ala His Leu Asp Arg Leu Leu Asp Gln Leu Arg Gln Gln Ser 
                565                 570                 575     


Asp Lys Glu Thr Leu Ala Phe His Leu Glu Lys Val Lys Asp Tyr Leu 
            580                 585                 590         


Lys Asn Met Lys Ser Arg Tyr Glu Cys Phe His Thr Leu Leu Thr Lys 
        595                 600                 605             


Glu Val Met Glu Tyr Pro Ala Ile Met Leu Lys Glu Leu Asn Ser Tyr 
    610                 615                 620                 


Ser Ser Ala Leu Ser Gln Tyr Phe Phe Val Arg Glu Ile Phe Glu Gln 
625                 630                 635                 640 


Asn Leu Ala Gly Glu Val Ile Phe Lys Phe Arg Gln Pro Glu Ala His 
                645                 650                 655     


Glu Lys Pro Ser Gln Lys Arg Val Lys Lys Leu Arg Lys Lys Gln Gly 
            660                 665                 670         


Ser Lys Glu Asp Met Thr Arg Ser Glu Glu Ser Ile Ser Ser Gly Thr 
        675                 680                 685             


Ser Thr Ala Arg Ser Val Glu Glu Val Glu Glu Glu Asn Asp Gln Glu 
    690                 695                 700                 


Met Glu Ser Phe Ile Thr Glu Glu Val Leu Gly Gln Gln Lys Lys Ser 
705                 710                 715                 720 


Pro Leu His Ala Lys Met Asp Glu Ser Lys Glu Gly Ser Ile Gln Gly 
                725                 730                 735     


Leu Glu Glu Met Gln Val Glu Arg Glu Gly Ser Leu Asn Pro Ser Leu 
            740                 745                 750         


Asn Glu Glu Asn Val Lys Gly Gln Gly Glu Lys Lys Glu Glu Ser Glu 
        755                 760                 765             


Glu Glu Asp Glu Lys Glu Glu Glu Glu Glu Glu Glu Lys Leu Glu Glu 
    770                 775                 780                 


Glu Lys Glu Glu Lys Glu Ala Gln Glu Glu Gln Glu Ser Leu Ser Val 
785                 790                 795                 800 


Gly Glu Glu Glu Asp Lys Glu Glu Gly Leu Glu Glu Ile Tyr Tyr Glu 
                805                 810                 815     


Asp Met Glu Ser Phe Thr Ile Ser Ser Gly Asn Thr Tyr Phe Val Phe 
            820                 825                 830         


Val Pro Leu Glu Glu Glu His Cys Arg Lys Ser His Ser Thr Phe Ser 
        835                 840                 845             


Ala Met Phe Ile Asn Asp Thr Ser Ser Ala Lys Phe Ile Glu Gln Val 
    850                 855                 860                 


Thr Ile Pro Ser Arg Leu Ile Leu Glu Ile Lys Lys Gln Leu Arg Ala 
865                 870                 875                 880 


Gly Phe Phe Glu His Leu Glu Lys Trp Phe Asp Gln Cys Ser Leu Asn 
                885                 890                 895     


Thr Arg Val Thr Val Ala Thr Lys Ile Asn Glu Leu Asp Ser Glu Leu 
            900                 905                 910         


Glu Leu His Leu His Leu His Gln Pro Arg Ala Gln Gln Ile Glu Lys 
        915                 920                 925             


Asp Ile His Asn Val Arg Ala Ala Glu Leu Leu Leu His Gln Glu Gln 
    930                 935                 940                 


Leu Asp Ser His Cys Ala Gly Val Thr Glu Thr Leu Lys Lys Lys Arg 
945                 950                 955                 960 


Leu Met Phe Cys Gln Phe Gln Glu Glu Gln Asn Val Arg Ser Lys Asn 
                965                 970                 975     


Phe Arg Leu Lys Ile Tyr Asp Met Glu His Ile Phe Leu Asn Ala Thr 
            980                 985                 990         


Arg Ser Gln Lys Leu Val Thr Leu  Ser Asn Thr Leu His  Gln Glu Leu 
        995                 1000                 1005             


Leu Ser  Tyr Val Asp Val Thr  Gln Val Ser Leu Arg  Ser Phe Arg 
    1010                 1015                 1020             


Gln Tyr  Leu Glu Glu Ser Leu  Gly Lys Leu Arg Tyr  Ser Asn Ile 
    1025                 1030                 1035             


Glu Phe  Ile Lys His Cys Arg  Leu Phe Ser Glu Gly  Gly Asn Phe 
    1040                 1045                 1050             


Ser Pro  Lys Glu Ile Asn Ser  Leu Cys Ser Arg Leu  Glu Lys Glu 
    1055                 1060                 1065             


Ala Ala  Arg Ile Glu Leu Val  Glu Ser Val Ile Met  Leu Asn Met 
    1070                 1075                 1080             


Glu Lys  Leu Glu Asn Glu Tyr  Leu Asp Gln Ala Asn  Asp Val Ile 
    1085                 1090                 1095             


Asn Lys  Phe Glu Ser Lys Phe  His Asn Leu Ser Val  Asp Leu Ile 
    1100                 1105                 1110             


Phe Ile  Glu Lys Ile Gln Arg  Leu Leu Thr Asn Leu  Gln Val Lys 
    1115                 1120                 1125             


Ile Lys  Cys Gln Val Ala Lys  Ser Asn Ser Gln Thr  Asn Gly Leu 
    1130                 1135                 1140             


Asn Phe  Ser Leu Gln Gln Leu  Gln Asn Lys Ile Lys  Thr Cys Gln 
    1145                 1150                 1155             


Glu Ser  Arg Gly Glu Lys Thr  Thr Val Thr Thr Glu  Glu Leu Leu 
    1160                 1165                 1170             


Ser Phe  Val Gln Thr Trp Lys  Glu Lys Leu Ser Gln  Arg Ile Gln 
    1175                 1180                 1185             


Tyr Leu  Asn Cys Ser Leu Asp  Arg Val Ser Met Thr  Glu Leu Val 
    1190                 1195                 1200             


Phe Thr  Asn Thr Ile Leu Lys  Asp Gln Glu Glu Asp  Ser Asp Ile 
    1205                 1210                 1215             


Leu Thr  Ser Ser Glu Ala Leu  Glu Glu Glu Ala Lys  Leu Asp Val 
    1220                 1225                 1230             


Val Thr  Pro Glu Ser Phe Thr  Gln Leu Ser Arg Val  Gly Lys Pro 
    1235                 1240                 1245             


Leu Ile  Glu Asp Pro Ala Val  Asp Val Ile Arg Lys  Leu Leu Gln 
    1250                 1255                 1260             


Leu Pro  Asn Thr Lys Trp Pro  Thr His His Cys Asp  Lys Asp Pro 
    1265                 1270                 1275             


Ser Gln  Thr Gly Arg Gly Ala  Trp Ala Cys Gly Ser  Arg Gly Ser 
    1280                 1285                 1290             


Ser Glu  Ala Gly Ala Gly Gly  Ala Val Cys Ser Pro  Pro Val Leu 
    1295                 1300                 1305             


Cys Ser  Cys Pro Gly Pro Ser  Ser Pro Lys Gly Phe  Lys Arg His 
    1310                 1315                 1320             


Arg Cys  Gln Pro Glu Asn Ser  Gly Lys Lys Ala Val  Pro Ser Ala 
    1325                 1330                 1335             


Ser Ala  Thr Ser Ala Gly Ser  Phe Thr Pro His Pro  Lys Pro Asn 
    1340                 1345                 1350             


Lys Met  Glu Arg Lys Tyr Arg  Val Leu Gly Asp Lys  Pro Pro Pro 
    1355                 1360                 1365             


Ala Ala  Glu Asp Phe Lys Gly  Ile Ile Leu Thr Leu  Leu Trp Glu 
    1370                 1375                 1380             


Ser Ser  Glu Asn Leu Leu Thr  Val Ala Glu Glu Phe  Tyr Arg Lys 
    1385                 1390                 1395             


Glu Lys  Arg Pro Val Thr Arg  Pro Asp Cys Met Cys  Asp Thr Phe 
    1400                 1405                 1410             


Asp Gln  Cys Ala Glu Asn Ile  Ser Lys Lys Ile Leu  Glu Tyr Gln 
    1415                 1420                 1425             


Ser Gln  Ala Asn Lys Tyr His  Asn Ser Cys Leu Ile  Glu Leu Arg 
    1430                 1435                 1440             


Ile Gln  Ile Arg Arg Phe Glu  Glu Leu Leu Pro Gln  Val Cys Trp 
    1445                 1450                 1455             


Leu Val  Met Glu Asn Phe Lys  Glu His His Trp Lys  Lys Phe Phe 
    1460                 1465                 1470             


Thr Ser  Val Lys Glu Ile Arg  Gly Gln Phe Glu Glu  Gln Gln Lys 
    1475                 1480                 1485             


Arg Leu  Glu Lys Arg Lys Asp  Lys Asn Ala Gln Lys  Leu His Leu 
    1490                 1495                 1500             


Asn Leu  Gly His Pro Val His  Phe Gln Glu Met Glu  Ser Leu His 
    1505                 1510                 1515             


Leu Ser  Glu Glu Glu Arg Gln  Glu Glu Leu Asp Ser  Met Ile Arg 
    1520                 1525                 1530             


Met Asn  Lys Glu Lys Leu Glu  Glu Cys Thr Arg Arg  Asn Gly Gln 
    1535                 1540                 1545             


Val Phe  Ile Thr Asn Leu Ala  Thr Phe Thr Glu Lys  Phe Leu Leu 
    1550                 1555                 1560             


Gln Leu  Asp Glu Val Val Thr  Ile Asp Asp Val Gln  Val Ala Arg 
    1565                 1570                 1575             


Met Glu  Pro Pro Lys Gln Lys  Leu Ser Met Leu Ile  Arg Arg Lys 
    1580                 1585                 1590             


Leu Ala  Gly Leu Ser Leu Lys  Glu Glu Ser Glu Lys  Pro Leu Ile 
    1595                 1600                 1605             


Glu Arg  Gly Ser Arg Lys Trp  Pro Gly Ile Lys Pro  Thr Glu Val 
    1610                 1615                 1620             


Thr Ile  Gln Asn Lys Ile Leu  Leu Gln Pro Thr Ser  Ser Ile Ser 
    1625                 1630                 1635             


Thr Thr  Lys Thr Thr Leu Gly  His Leu Ala Ala Val  Glu Ala Arg 
    1640                 1645                 1650             


Asp Ala  Val Tyr Leu Lys Tyr  Leu Ala Ser Phe Glu  Glu Glu Leu 
    1655                 1660                 1665             


Lys Arg  Ile Gln Asp Asp Cys  Thr Ser Gln Ile Lys  Glu Ala Gln 
    1670                 1675                 1680             


Arg Trp  Lys Asp Ser Trp Lys  Gln Ser Leu His Thr  Ile Gln Gly 
    1685                 1690                 1695             


Leu Tyr  Val 
    1700     


<210>  1681
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC181__Homo_sapiens__NP_067002

<400>  1681

Met Asn Glu Asn Lys Asp Thr Asp Ser Lys Lys Ser Glu Glu Tyr Glu 
1               5                   10                  15      


Asp Asp Phe Glu Lys Asp Leu Glu Trp Leu Ile Asn Glu Asn Glu Lys 
            20                  25                  30          


Ser Asp Ala Ser Ile Ile Glu Met Ala Cys Glu Lys Glu Glu Asn Ile 
        35                  40                  45              


Asn Gln Asp Leu Lys Glu Asn Glu Thr Val Met Glu His Thr Lys Arg 
    50                  55                  60                  


His Ser Asp Pro Asp Lys Ser Leu Gln Asp Glu Val Ser Pro Arg Arg 
65                  70                  75                  80  


Asn Asp Ile Ile Ser Val Pro Gly Ile Gln Pro Leu Asp Pro Ile Ser 
                85                  90                  95      


Asp Ser Asp Ser Glu Asn Ser Phe Gln Glu Ser Lys Leu Glu Ser Gln 
            100                 105                 110         


Lys Asp Leu Glu Glu Glu Glu Asp Glu Glu Val Arg Arg Tyr Ile Met 
        115                 120                 125             


Glu Lys Ile Val Gln Ala Asn Lys Leu Leu Gln Asn Gln Glu Pro Val 
    130                 135                 140                 


Asn Asp Lys Arg Glu Arg Lys Leu Lys Phe Lys Asp Gln Leu Val Asp 
145                 150                 155                 160 


Leu Glu Val Pro Pro Leu Glu Asp Thr Thr Thr Phe Lys Asn Tyr Phe 
                165                 170                 175     


Glu Asn Glu Arg Asn Met Phe Gly Lys Leu Ser Gln Leu Cys Ile Ser 
            180                 185                 190         


Asn Asp Phe Gly Gln Glu Asp Val Leu Leu Ser Leu Thr Asn Gly Ser 
        195                 200                 205             


Cys Glu Glu Asn Lys Asp Arg Thr Ile Leu Val Glu Arg Asp Gly Lys 
    210                 215                 220                 


Phe Glu Leu Leu Asn Leu Gln Asp Ile Ala Ser Gln Gly Phe Leu Pro 
225                 230                 235                 240 


Pro Ile Asn Asn Ala Asn Ser Thr Glu Asn Asp Pro Gln Gln Leu Leu 
                245                 250                 255     


Pro Arg Ser Ser Asn Ser Ser Val Ser Gly Thr Lys Lys Glu Asp Ser 
            260                 265                 270         


Thr Ala Lys Ile His Ala Val Thr His Ser Ser Thr Gly Glu Pro Leu 
        275                 280                 285             


Ala Tyr Ile Ala Gln Pro Pro Leu Asn Arg Lys Thr Cys Pro Ser Ser 
    290                 295                 300                 


Ala Val Asn Ser Asp Arg Ser Lys Gly Asn Gly Lys Ser Asn His Arg 
305                 310                 315                 320 


Thr Gln Ser Ala His Ile Ser Pro Val Thr Ser Thr Tyr Cys Leu Ser 
                325                 330                 335     


Pro Arg Gln Lys Glu Leu Gln Lys Gln Leu Glu Glu Lys Arg Glu Lys 
            340                 345                 350         


Leu Lys Arg Glu Glu Glu Arg Arg Lys Ile Glu Glu Glu Lys Glu Lys 
        355                 360                 365             


Lys Arg Glu Asn Asp Ile Val Phe Lys Ala Trp Leu Gln Lys Lys Arg 
    370                 375                 380                 


Glu Gln Val Leu Glu Met Arg Arg Ile Gln Arg Ala Lys Glu Ile Glu 
385                 390                 395                 400 


Asp Met Asn Ser Arg Glu Asn Arg Asp Pro Gln Gln Ala Phe Arg Leu 
                405                 410                 415     


Trp Leu Lys Lys Lys His Glu Glu Gln Met Lys Glu Arg Gln Thr Glu 
            420                 425                 430         


Glu Leu Arg Lys Gln Glu Glu Cys Leu Phe Phe Leu Lys Gly Thr Glu 
        435                 440                 445             


Gly Arg Glu Arg Ala Phe Lys Gln Trp Leu Arg Arg Lys Arg Met Glu 
    450                 455                 460                 


Lys Met Ala Glu Gln Gln Ala Val Arg Glu Arg Thr Arg Gln Leu Arg 
465                 470                 475                 480 


Leu Glu Ala Lys Arg Ser Lys Gln Leu Gln His His Leu Tyr Met Ser 
                485                 490                 495     


Glu Ala Lys Pro Phe Arg Phe Thr Asp His Tyr Asn 
            500                 505             


<210>  1682
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC185__Homo_sapiens__NP_689823

<400>  1682

Met Ala Gly Phe Ser His Phe Ser Gln Pro Pro Tyr Arg Asp Leu Trp 
1               5                   10                  15      


Glu Pro Pro Arg Pro Gly Gly Glu Arg Glu Ser Thr Gln Arg Leu Gly 
            20                  25                  30          


Gly Gln Arg Ser Gly Ala Asp Ser Thr Ala Cys Ser Arg Ala Gly Thr 
        35                  40                  45              


Pro Gly Ala Glu Ser Glu Ala Gly Ala Cys Trp Leu His Pro His Cys 
    50                  55                  60                  


Ser Phe Thr Pro Arg Pro Arg Arg Arg Gly Cys Ser Asp Ser Leu Arg 
65                  70                  75                  80  


Gly Ser Arg Ser Leu Ser Asp Val Ala Arg Arg Pro Leu Glu Arg Ser 
                85                  90                  95      


Arg Lys His Arg Pro Arg Ser Arg Arg Leu Glu Asp Ala Trp Gly Glu 
            100                 105                 110         


Thr Gly Thr Lys Pro Arg Pro Ala Trp Gln Pro Gln Thr Gln Leu Pro 
        115                 120                 125             


Pro Gln Arg Pro Gln Pro Cys Pro His Tyr Pro Leu Ala Gln Gly Asp 
    130                 135                 140                 


Ser Pro Pro Pro Cys Pro Gly Gly Ala Gly Thr Pro Leu Ser Gly Thr 
145                 150                 155                 160 


Phe Arg Val Glu Lys Ala Gln Gly Gly Asp Gln Trp Ala Val Pro Leu 
                165                 170                 175     


Gly Arg His Leu Gly Arg Trp Ser Pro Ser Ser Val Pro Ser Glu Arg 
            180                 185                 190         


Ser Ser Val Pro Ser Gln Lys Phe Lys Arg His Ser Ala Cys Val Cys 
        195                 200                 205             


Ala Gln Lys Arg Asp Ser Ser Asp Gln Val Glu Ser Leu Ala Ser Arg 
    210                 215                 220                 


Asp Ser Gln Pro Leu Ala Ser Ser Lys Glu Met Arg Ser Pro His Thr 
225                 230                 235                 240 


Gln Val Leu Lys Ser Lys Leu Glu Glu Val Val Val Ser Ser Gln Asp 
                245                 250                 255     


Gln Gln Ile Val Ala Leu Val Leu Thr Arg Leu Lys Lys Ala Gln Arg 
            260                 265                 270         


Ile Arg Glu Leu Gln Gln Gln Ala Ala Lys Ala Trp Glu Glu Leu Lys 
        275                 280                 285             


Arg Ser Asp Gln Lys Val Gln Met Thr Leu Glu Arg Glu Arg Arg Leu 
    290                 295                 300                 


Leu Leu Arg Gln Ser Gln Glu Gln Trp Gln Glu Lys Glu Gln Arg Lys 
305                 310                 315                 320 


Thr Leu Gln Ser Pro Glu Gln Arg Gly Leu Arg Arg Asp Ser Gln Arg 
                325                 330                 335     


Lys Asn Val Pro Pro Gly Glu Ser Arg Trp Lys Glu Gln Pro Glu Asp 
            340                 345                 350         


Gln Glu Ser Pro Arg Gln Glu Lys Leu Glu Lys Ala Arg Ala Gln Ala 
        355                 360                 365             


Glu His Arg Lys Gln Cys Gln Val Arg Arg Leu Arg Glu Gln Glu Lys 
    370                 375                 380                 


Met Leu Arg Asn Leu Arg Glu Gln His Ser Leu Gln Leu Gln Arg Arg 
385                 390                 395                 400 


Leu Val Glu Ala Cys Arg Lys Arg His Leu His Ala Val Glu Gly Gln 
                405                 410                 415     


Lys Lys Val Gln Asp Thr Asn Leu Ser Ser Leu Ile Asn Tyr Gln Ala 
            420                 425                 430         


Arg Lys Val Leu Met Asp Cys Gln Ala Lys Ala Glu Glu Leu Leu Arg 
        435                 440                 445             


Gln Leu Ser Leu Glu Gln Ser Phe Gln Arg Ser Gln Glu Ile His Gln 
    450                 455                 460                 


Gly Leu Arg Lys Glu Arg Gln Arg Glu Leu Arg Glu Lys Ala Gln Lys 
465                 470                 475                 480 


Glu Glu Glu Gln Leu Gln Gln Ala Arg Trp Arg Ala Gly Glu Ser Glu 
                485                 490                 495     


Glu Gln Arg Lys Met Arg Lys Arg Ile Leu Val Glu Leu Ala Asp Glu 
            500                 505                 510         


Lys Ile Arg Gln Ala Arg Ser His Val His Lys Thr Thr Arg Asp Lys 
        515                 520                 525             


Val Gln His Leu Arg Glu Leu Asn His Leu Arg Glu Lys Asn His His 
    530                 535                 540                 


Ile Leu Lys Leu Lys Ala Glu Lys Glu Glu Lys Cys His Ile Glu Gly 
545                 550                 555                 560 


Ile Lys Glu Ala Ile Lys Lys Lys Glu Gln Arg Val Gln His Ile Ser 
                565                 570                 575     


Gln Gly Lys Asp Pro Asn Phe Gln Glu Phe Gln Lys Leu Pro Gln Ala 
            580                 585                 590         


Ser Arg Arg Glu Glu Arg Ala Pro Pro Asn Ser Ser Leu Asp Gln Met 
        595                 600                 605             


Val Leu Glu Ala Gln Leu Arg Ala Cys Gln Gln Asn Arg Gly Tyr 
    610                 615                 620             


<210>  1683
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC22__Homo_sapiens__NP_054727

<400>  1683

Met Glu Glu Ala Asp Arg Ile Leu Ile His Ser Leu Arg Gln Ala Gly 
1               5                   10                  15      


Thr Ala Val Pro Pro Asp Val Gln Thr Leu Arg Ala Phe Thr Thr Glu 
            20                  25                  30          


Leu Val Val Glu Ala Val Val Arg Cys Leu Arg Val Ile Asn Pro Ala 
        35                  40                  45              


Val Gly Ser Gly Leu Ser Pro Leu Leu Pro Leu Ala Met Ser Ala Arg 
    50                  55                  60                  


Phe Arg Leu Ala Met Ser Leu Ala Gln Ala Cys Met Asp Leu Gly Tyr 
65                  70                  75                  80  


Pro Leu Glu Leu Gly Tyr Gln Asn Phe Leu Tyr Pro Ser Glu Pro Asp 
                85                  90                  95      


Leu Arg Asp Leu Leu Leu Phe Leu Ala Glu Arg Leu Pro Thr Asp Ala 
            100                 105                 110         


Ser Glu Asp Ala Asp Gln Pro Ala Gly Asp Ser Ala Ile Leu Leu Arg 
        115                 120                 125             


Ala Ile Gly Ser Gln Ile Arg Asp Gln Leu Ala Leu Pro Trp Val Pro 
    130                 135                 140                 


Pro His Leu Arg Thr Pro Lys Leu Gln His Leu Gln Gly Ser Ala Leu 
145                 150                 155                 160 


Gln Lys Pro Phe His Ala Ser Arg Leu Val Val Pro Glu Leu Ser Ser 
                165                 170                 175     


Arg Gly Glu Pro Arg Glu Phe Gln Ala Ser Pro Leu Leu Leu Pro Val 
            180                 185                 190         


Pro Thr Gln Val Pro Gln Pro Val Gly Arg Val Ala Ser Leu Leu Glu 
        195                 200                 205             


His His Ala Leu Gln Leu Cys Gln Gln Thr Gly Arg Asp Arg Pro Gly 
    210                 215                 220                 


Asp Glu Asp Trp Val His Arg Thr Ser Arg Leu Pro Pro Gln Glu Asp 
225                 230                 235                 240 


Thr Arg Ala Gln Arg Gln Arg Leu Gln Lys Gln Leu Thr Glu His Leu 
                245                 250                 255     


Arg Gln Ser Trp Gly Leu Leu Gly Ala Pro Ile Gln Ala Arg Asp Leu 
            260                 265                 270         


Gly Glu Leu Leu Gln Ala Trp Gly Ala Gly Ala Lys Thr Gly Ala Pro 
        275                 280                 285             


Lys Gly Ser Arg Phe Thr His Ser Glu Lys Phe Thr Phe His Leu Glu 
    290                 295                 300                 


Pro Gln Ala Gln Ala Thr Gln Val Ser Asp Val Pro Ala Thr Ser Arg 
305                 310                 315                 320 


Arg Pro Glu Gln Val Thr Trp Ala Ala Gln Glu Gln Glu Leu Glu Ser 
                325                 330                 335     


Leu Arg Glu Gln Leu Glu Gly Val Asn Arg Ser Ile Glu Glu Val Glu 
            340                 345                 350         


Ala Asp Met Lys Thr Leu Gly Val Ser Phe Val Gln Ala Glu Ser Glu 
        355                 360                 365             


Cys Arg His Ser Lys Leu Ser Thr Ala Glu Arg Glu Gln Ala Leu Arg 
    370                 375                 380                 


Leu Lys Ser Arg Ala Val Glu Leu Leu Pro Asp Gly Thr Ala Asn Leu 
385                 390                 395                 400 


Ala Lys Leu Gln Leu Val Val Glu Asn Ser Ala Gln Arg Val Ile His 
                405                 410                 415     


Leu Ala Gly Gln Trp Glu Lys His Arg Val Pro Leu Leu Ala Glu Tyr 
            420                 425                 430         


Arg His Leu Arg Lys Leu Gln Asp Cys Arg Glu Leu Glu Ser Ser Arg 
        435                 440                 445             


Arg Leu Ala Glu Ile Gln Glu Leu His Gln Ser Val Arg Ala Ala Ala 
    450                 455                 460                 


Glu Glu Ala Arg Arg Lys Glu Glu Val Tyr Lys Gln Leu Met Ser Glu 
465                 470                 475                 480 


Leu Glu Thr Leu Pro Arg Asp Val Ser Arg Leu Ala Tyr Thr Gln Arg 
                485                 490                 495     


Ile Leu Glu Ile Val Gly Asn Ile Arg Lys Gln Lys Glu Glu Ile Thr 
            500                 505                 510         


Lys Ile Leu Ser Asp Thr Lys Glu Leu Gln Lys Glu Ile Asn Ser Leu 
        515                 520                 525             


Ser Gly Lys Leu Asp Arg Thr Phe Ala Val Thr Asp Glu Leu Val Phe 
    530                 535                 540                 


Lys Asp Ala Lys Lys Asp Asp Ala Val Arg Lys Ala Tyr Lys Tyr Leu 
545                 550                 555                 560 


Ala Ala Leu His Glu Asn Cys Ser Gln Leu Ile Gln Thr Ile Glu Asp 
                565                 570                 575     


Thr Gly Thr Ile Met Arg Glu Val Arg Asp Leu Glu Glu Gln Ile Glu 
            580                 585                 590         


Thr Glu Leu Gly Lys Lys Thr Leu Ser Asn Leu Glu Lys Ile Arg Glu 
        595                 600                 605             


Asp Tyr Arg Ala Leu Arg Gln Glu Asn Ala Gly Leu Leu Gly Arg Val 
    610                 615                 620                 


Arg Glu Ala 
625         


<210>  1684
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC28A__Homo_sapiens__NP_056254

<400>  1684

Met Pro Arg Ala Glu Pro Arg Ala Thr Leu Gly Glu Gln Glu Lys Ala 
1               5                   10                  15      


Gly Leu Pro Leu Gly Ala Trp Arg Leu Tyr Leu Leu Arg His Phe Arg 
            20                  25                  30          


Lys Gln Thr Glu Leu Arg Arg Ser Gly Ser Arg Asp Val Thr Gly Ala 
        35                  40                  45              


Leu Leu Val Ala Ala Ala Val Ala Ser Glu Ala Val Gly Ser Leu Arg 
    50                  55                  60                  


Val Ala Glu Gly Gly Pro Asn Thr Leu Leu Leu Gln Val Leu Arg Ser 
65                  70                  75                  80  


Trp Pro Trp Cys Asn Lys Glu Leu Lys Thr Met Glu Glu Arg Lys Val 
                85                  90                  95      


Lys Arg Arg Ser Pro Lys Ser Phe Ser Ala His Cys Thr Gln Val Val 
            100                 105                 110         


Asn Ala Lys Lys Asn Ala Ile Pro Val Ser Lys Ser Thr Gly Phe Ser 
        115                 120                 125             


Asn Pro Ala Ser Gln Ser Thr Ser Gln Arg Pro Lys Leu Lys Arg Val 
    130                 135                 140                 


Met Lys Glu Lys Thr Lys Pro Gln Gly Gly Glu Gly Lys Gly Ala Gln 
145                 150                 155                 160 


Ser Thr Pro Ile Gln His Ser Phe Leu Thr Asp Val Ser Asp Val Gln 
                165                 170                 175     


Glu Met Glu Arg Gly Leu Leu Ser Leu Leu Asn Asp Phe His Ser Gly 
            180                 185                 190         


Lys Leu Gln Ala Phe Gly Asn Glu Cys Ser Ile Glu Gln Met Glu His 
        195                 200                 205             


Val Arg Gly Met Gln Glu Lys Leu Ala Arg Leu Asn Leu Glu Leu Tyr 
    210                 215                 220                 


Gly Glu Leu Glu Glu Leu Pro Glu Asp Lys Arg Lys Thr Ala Ser Asp 
225                 230                 235                 240 


Ser Asn Leu Asp Arg Leu Leu Ser Asp Leu Glu Glu Leu Asn Ser Ser 
                245                 250                 255     


Ile Gln Lys Leu His Leu Ala Asp Ala Gln Asp Val Pro Asn Thr Ser 
            260                 265                 270         


Ala Ser 
        


<210>  1685
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC39__Homo_sapiens__NP_852091

<400>  1685

Met Ser Ser Glu Phe Leu Ala Glu Leu His Trp Glu Asp Gly Phe Ala 
1               5                   10                  15      


Ile Pro Val Ala Asn Glu Glu Asn Lys Leu Leu Glu Asp Gln Leu Ser 
            20                  25                  30          


Lys Leu Lys Asp Glu Arg Ala Ser Leu Gln Asp Glu Leu Arg Glu Tyr 
        35                  40                  45              


Glu Glu Arg Ile Asn Ser Met Thr Ser His Phe Lys Asn Val Lys Gln 
    50                  55                  60                  


Glu Leu Ser Ile Thr Gln Ser Leu Cys Lys Ala Arg Glu Arg Glu Thr 
65                  70                  75                  80  


Glu Ser Glu Glu His Phe Lys Ala Ile Ala Gln Arg Glu Leu Gly Arg 
                85                  90                  95      


Val Lys Asp Glu Ile Gln Arg Leu Glu Asn Glu Met Ala Ser Ile Leu 
            100                 105                 110         


Glu Lys Lys Ser Asp Lys Glu Asn Gly Ile Phe Lys Ala Thr Gln Lys 
        115                 120                 125             


Leu Asp Gly Leu Lys Cys Gln Met Asn Trp Asp Gln Gln Ala Leu Glu 
    130                 135                 140                 


Ala Trp Leu Glu Glu Ser Ala His Lys Asp Ser Asp Ala Leu Thr Leu 
145                 150                 155                 160 


Gln Lys Tyr Ala Gln Gln Asp Asp Asn Lys Ile Arg Ala Leu Thr Leu 
                165                 170                 175     


Gln Leu Glu Arg Leu Thr Leu Glu Cys Asn Gln Lys Arg Lys Ile Leu 
            180                 185                 190         


Asp Asn Glu Leu Thr Glu Thr Ile Ser Ala Gln Leu Glu Leu Asp Lys 
        195                 200                 205             


Ala Ala Gln Asp Phe Arg Lys Ile His Asn Glu Arg Gln Glu Leu Ile 
    210                 215                 220                 


Lys Gln Trp Glu Asn Thr Ile Glu Gln Met Gln Lys Arg Asp Gly Asp 
225                 230                 235                 240 


Ile Asp Asn Cys Ala Leu Glu Leu Ala Arg Ile Lys Gln Glu Thr Arg 
                245                 250                 255     


Glu Lys Glu Asn Leu Val Lys Glu Lys Ile Lys Phe Leu Glu Ser Glu 
            260                 265                 270         


Ile Gly Asn Asn Thr Glu Phe Glu Lys Arg Ile Ser Val Ala Asp Arg 
        275                 280                 285             


Lys Leu Leu Lys Cys Arg Thr Ala Tyr Gln Asp His Glu Thr Ser Arg 
    290                 295                 300                 


Ile Gln Leu Lys Gly Glu Leu Asp Ser Leu Lys Ala Thr Val Asn Arg 
305                 310                 315                 320 


Thr Ser Ser Asp Leu Glu Ala Leu Arg Lys Asn Ile Ser Lys Ile Lys 
                325                 330                 335     


Lys Asp Ile His Glu Glu Thr Ala Arg Leu Gln Lys Thr Lys Asn His 
            340                 345                 350         


Asn Glu Ile Ile Gln Thr Lys Leu Lys Glu Ile Thr Glu Lys Thr Met 
        355                 360                 365             


Ser Val Glu Glu Lys Ala Thr Asn Leu Glu Asp Met Leu Lys Glu Glu 
    370                 375                 380                 


Glu Lys Asp Val Lys Glu Val Asp Val Gln Leu Asn Leu Ile Lys Gly 
385                 390                 395                 400 


Val Leu Phe Lys Lys Ala Gln Glu Leu Gln Thr Glu Thr Met Lys Glu 
                405                 410                 415     


Lys Ala Val Leu Ser Glu Ile Glu Gly Thr Arg Ser Ser Leu Lys His 
            420                 425                 430         


Leu Asn His Gln Leu Gln Lys Leu Asp Phe Glu Thr Leu Lys Gln Gln 
        435                 440                 445             


Glu Ile Met Tyr Ser Gln Asp Phe His Ile Gln Gln Val Glu Arg Arg 
    450                 455                 460                 


Met Ser Arg Leu Lys Gly Glu Ile Asn Ser Glu Glu Lys Gln Ala Leu 
465                 470                 475                 480 


Glu Ala Lys Ile Val Glu Leu Arg Lys Ser Leu Glu Glu Lys Lys Ser 
                485                 490                 495     


Thr Cys Gly Leu Leu Glu Thr Gln Ile Lys Lys Leu His Asn Asp Leu 
            500                 505                 510         


Tyr Phe Ile Lys Lys Ala His Ser Lys Asn Ser Asp Glu Lys Gln Ser 
        515                 520                 525             


Leu Met Thr Lys Ile Asn Glu Leu Asn Leu Phe Ile Asp Arg Ser Glu 
    530                 535                 540                 


Lys Glu Leu Asp Lys Ala Lys Gly Phe Lys Gln Asp Leu Met Ile Glu 
545                 550                 555                 560 


Asp Asn Leu Leu Lys Leu Glu Val Lys Arg Thr Arg Glu Met Leu His 
                565                 570                 575     


Ser Lys Ala Glu Glu Val Leu Ser Leu Glu Lys Arg Lys Gln Gln Leu 
            580                 585                 590         


Tyr Thr Ala Met Glu Glu Arg Thr Glu Glu Ile Lys Val His Lys Thr 
        595                 600                 605             


Met Leu Ala Ser Gln Ile Arg Tyr Val Asp Gln Glu Arg Glu Asn Ile 
    610                 615                 620                 


Ser Thr Glu Phe Arg Glu Arg Leu Ser Lys Ile Glu Lys Leu Lys Asn 
625                 630                 635                 640 


Arg Tyr Glu Ile Leu Thr Val Val Met Leu Pro Pro Glu Gly Glu Glu 
                645                 650                 655     


Glu Lys Thr Gln Ala Tyr Tyr Val Ile Lys Ala Ala Gln Glu Lys Glu 
            660                 665                 670         


Glu Leu Gln Arg Glu Gly Asp Cys Leu Asp Ala Lys Ile Asn Lys Ala 
        675                 680                 685             


Glu Lys Glu Ile Tyr Ala Leu Glu Asn Thr Leu Gln Val Leu Asn Ser 
    690                 695                 700                 


Cys Asn Asn Asn Tyr Lys Gln Ser Phe Lys Lys Val Thr Pro Ser Ser 
705                 710                 715                 720 


Asp Glu Tyr Glu Leu Lys Ile Gln Leu Glu Glu Gln Lys Arg Ala Val 
                725                 730                 735     


Asp Glu Lys Tyr Arg Tyr Lys Gln Arg Gln Ile Arg Glu Leu Gln Glu 
            740                 745                 750         


Asp Ile Gln Ser Met Glu Asn Thr Leu Asp Val Ile Glu His Leu Ala 
        755                 760                 765             


Asn Asn Val Lys Glu Lys Leu Ser Glu Lys Gln Ala Tyr Ser Phe Gln 
    770                 775                 780                 


Leu Ser Lys Glu Thr Glu Glu Gln Lys Pro Lys Leu Glu Arg Val Thr 
785                 790                 795                 800 


Lys Gln Cys Ala Lys Leu Thr Lys Glu Ile Arg Leu Leu Lys Asp Thr 
                805                 810                 815     


Lys Asp Glu Thr Met Glu Glu Gln Asp Ile Lys Leu Arg Glu Met Lys 
            820                 825                 830         


Gln Phe His Lys Val Ile Asp Glu Met Leu Val Asp Ile Ile Glu Glu 
        835                 840                 845             


Asn Thr Glu Ile Arg Ile Ile Leu Gln Thr Tyr Phe Gln Gln Ser Gly 
    850                 855                 860                 


Leu Glu Leu Pro Thr Ala Ser Thr Lys Gly Ser Arg Gln Ser Ser Arg 
865                 870                 875                 880 


Ser Pro Ser His Thr Ser Leu Ser Ala Arg Ser Ser Arg Ser Thr Ser 
                885                 890                 895     


Thr Ser Thr Ser Gln Ser Ser Ile Lys Val Leu Glu Leu Lys Phe Pro 
            900                 905                 910         


Ala Ser Ser Ser Leu Val Gly Ser Pro Ser Arg Pro Ser Ser Ala Ser 
        915                 920                 925             


Ser Ser Ser Ser Asn Val Lys Ser Lys Lys Ser Ser Lys 
    930                 935                 940     


<210>  1686
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC3__Homo_sapiens__NP_001269587

<400>  1686

Met Asp Glu Asn Tyr Asn Leu Leu Pro His Gly Val Asn Phe Gln Asp 
1               5                   10                  15      


Ala Ile Phe Pro Asp Thr Gln Glu Asn Arg Arg Met Phe Ser Ser Leu 
            20                  25                  30          


Phe Gln Phe Ser Asn Cys Ser Gln Gly Gln Gln Leu Ala Thr Phe Ser 
        35                  40                  45              


Ser Asp Trp Glu Ile Gln Glu Asp Ser Arg Leu Met Cys Ser Ser Val 
    50                  55                  60                  


Gln Lys Ala Leu Phe Glu Glu Glu Asp His Val Lys Lys Leu Gln Gln 
65                  70                  75                  80  


Lys Val Ala Thr Leu Glu Lys Arg Asn Arg Gln Leu Arg Glu Arg Val 
                85                  90                  95      


Lys Lys Val Lys Arg Ser Leu Arg Gln Ala Arg Lys Lys Gly Arg His 
            100                 105                 110         


Leu Glu Leu Ala Asn Gln Lys Leu Ser Glu Lys Leu Ala Ala Gly Ala 
        115                 120                 125             


Leu Pro His Ile Asn Ala Arg Gly Pro Val Arg Pro Pro Tyr Leu Arg 
    130                 135                 140                 


Gly 
145 


<210>  1687
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC40__Homo_sapiens__NP_001230271

<400>  1687

Met Ala Glu Pro Gly Gly Ala Ala Gly Arg Ser His Pro Glu Asp Gly 
1               5                   10                  15      


Ser Ala Ser Glu Gly Glu Lys Glu Gly Asn Asn Glu Ser His Met Val 
            20                  25                  30          


Ser Pro Pro Glu Lys Asp Asp Gly Gln Lys Gly Glu Glu Ala Val Gly 
        35                  40                  45              


Ser Thr Glu His Pro Glu Glu Val Thr Thr Gln Ala Glu Ala Ala Ile 
    50                  55                  60                  


Glu Glu Gly Glu Val Glu Thr Glu Gly Glu Ala Ala Val Glu Gly Glu 
65                  70                  75                  80  


Glu Glu Ala Val Ser Tyr Gly Asp Ala Glu Ser Glu Glu Glu Tyr Tyr 
                85                  90                  95      


Tyr Thr Glu Thr Ser Ser Pro Glu Gly Gln Ile Ser Ala Ala Asp Thr 
            100                 105                 110         


Thr Tyr Pro Tyr Phe Ser Pro Pro Gln Glu Leu Pro Gly Glu Glu Ala 
        115                 120                 125             


Tyr Asp Ser Val Ser Gly Glu Ala Gly Leu Gln Gly Phe Gln Gln Glu 
    130                 135                 140                 


Ala Thr Gly Pro Pro Glu Ser Arg Glu Arg Arg Val Thr Ser Pro Glu 
145                 150                 155                 160 


Pro Ser His Gly Val Leu Gly Pro Ser Glu Gln Met Gly Gln Val Thr 
                165                 170                 175     


Ser Gly Pro Ala Val Gly Arg Leu Thr Gly Ser Thr Glu Glu Pro Gln 
            180                 185                 190         


Gly Gln Val Leu Pro Met Gly Val Gln His Arg Phe Arg Leu Ser His 
        195                 200                 205             


Gly Ser Asp Ile Glu Ser Ser Asp Leu Glu Glu Phe Val Ser Gln Glu 
    210                 215                 220                 


Pro Val Ile Pro Pro Gly Val Pro Asp Ala His Pro Arg Glu Gly Asp 
225                 230                 235                 240 


Leu Pro Val Phe Gln Asp Gln Ile Gln Gln Pro Ser Thr Glu Glu Gly 
                245                 250                 255     


Ala Met Ala Glu Arg Val Glu Ser Glu Gly Ser Asp Glu Glu Ala Glu 
            260                 265                 270         


Asp Glu Gly Ser Gln Leu Val Val Leu Asp Pro Asp His Pro Leu Met 
        275                 280                 285             


Val Arg Phe Gln Ala Ala Leu Lys Asn Tyr Leu Asn Arg Gln Ile Glu 
    290                 295                 300                 


Lys Leu Lys Leu Asp Leu Gln Glu Leu Val Val Ala Thr Lys Gln Ser 
305                 310                 315                 320 


Arg Ala Gln Arg Gln Glu Leu Gly Val Asn Leu Tyr Glu Val Gln Gln 
                325                 330                 335     


His Leu Val His Leu Gln Lys Leu Leu Glu Lys Ser His Asp Arg His 
            340                 345                 350         


Ala Met Ala Ser Ser Glu Arg Arg Gln Lys Glu Glu Glu Leu Gln Ala 
        355                 360                 365             


Ala Arg Ala Leu Tyr Thr Lys Thr Cys Ala Ala Ala Asn Glu Glu Arg 
    370                 375                 380                 


Lys Lys Leu Ala Ala Leu Gln Thr Glu Met Glu Asn Leu Ala Leu His 
385                 390                 395                 400 


Leu Phe Tyr Met Gln Asn Ile Asp Gln Asp Met Arg Asp Asp Ile Arg 
                405                 410                 415     


Val Met Thr Gln Val Val Lys Lys Ala Glu Thr Glu Arg Ile Arg Ala 
            420                 425                 430         


Glu Ile Glu Lys Lys Lys Gln Asp Leu Tyr Val Asp Gln Leu Thr Thr 
        435                 440                 445             


Arg Ala Gln Gln Leu Glu Glu Asp Ile Ala Leu Phe Glu Ala Gln Tyr 
    450                 455                 460                 


Leu Ala Gln Ala Glu Asp Thr Arg Ile Leu Arg Lys Ala Val Ser Glu 
465                 470                 475                 480 


Ala Cys Thr Glu Ile Asp Ala Ile Ser Val Glu Lys Arg Arg Ile Met 
                485                 490                 495     


Gln Gln Trp Ala Ser Ser Leu Val Gly Met Lys His Arg Asp Glu Ala 
            500                 505                 510         


His Arg Ala Val Leu Glu Ala Leu Arg Gly Cys Gln His Gln Ala Lys 
        515                 520                 525             


Ser Thr Asp Gly Glu Ile Glu Ala Tyr Lys Lys Ser Ile Met Lys Glu 
    530                 535                 540                 


Glu Glu Lys Asn Glu Lys Leu Ala Ser Ile Leu Asn Arg Thr Glu Thr 
545                 550                 555                 560 


Glu Ala Thr Leu Leu Gln Lys Leu Thr Thr Gln Cys Leu Thr Lys Gln 
                565                 570                 575     


Val Ala Leu Gln Ser Gln Phe Asn Thr Tyr Arg Leu Thr Leu Gln Asp 
            580                 585                 590         


Thr Glu Asp Ala Leu Ser Gln Asp Gln Leu Glu Gln Met Ile Leu Thr 
        595                 600                 605             


Glu Glu Leu Gln Ala Ile Arg Gln Ala Ile Gln Gly Glu Leu Glu Leu 
    610                 615                 620                 


Arg Arg Lys Thr Asp Ala Ala Ile Arg Glu Lys Leu Gln Glu His Met 
625                 630                 635                 640 


Thr Ser Asn Lys Thr Thr Lys Tyr Phe Asn Gln Leu Ile Leu Arg Leu 
                645                 650                 655     


Gln Lys Glu Lys Thr Asn Met Met Thr His Leu Ser Lys Ile Asn Gly 
            660                 665                 670         


Asp Ile Ala Gln Thr Thr Leu Asp Ile Thr His Thr Ser Ser Arg Leu 
        675                 680                 685             


Asp Ala His Gln Lys Thr Leu Val Glu Leu Asp Gln Asp Val Lys Lys 
    690                 695                 700                 


Val Asn Glu Leu Ile Thr Asn Ser Gln Ser Glu Ile Ser Arg Arg Thr 
705                 710                 715                 720 


Ile Leu Ile Glu Arg Lys Gln Gly Leu Ile Asn Phe Leu Asn Lys Gln 
                725                 730                 735     


Leu Glu Arg Met Val Ser Glu Leu Gly Gly Glu Glu Val Gly Pro Leu 
            740                 745                 750         


Glu Leu Glu Ile Lys Arg Leu Ser Lys Leu Ile Asp Glu His Asp Gly 
        755                 760                 765             


Lys Ala Val Gln Ala Gln Val Thr Trp Leu Arg Leu Gln Gln Glu Met 
    770                 775                 780                 


Val Lys Val Thr Gln Glu Gln Glu Glu Gln Leu Ala Ser Leu Asp Ala 
785                 790                 795                 800 


Ser Lys Lys Glu Leu His Ile Met Glu Gln Lys Lys Leu Arg Val Glu 
                805                 810                 815     


Ser Lys Ile Glu Gln Glu Lys Lys Glu Gln Lys Glu Ile Glu His His 
            820                 825                 830         


Met Lys Asp Leu Asp Asn Asp Leu Lys Lys Leu Asn Met Leu Met Asn 
        835                 840                 845             


Lys Asn Arg Cys Ser Ser Glu Glu Leu Glu Gln Asn Asn Arg Val Thr 
    850                 855                 860                 


Glu Asn Glu Phe Val Arg Ser Leu Lys Ala Ser Glu Arg Glu Thr Ile 
865                 870                 875                 880 


Lys Met Gln Asp Lys Leu Asn Gln Leu Ser Glu Glu Lys Ala Thr Leu 
                885                 890                 895     


Leu Asn Gln Leu Val Glu Ala Glu His Gln Ile Met Leu Trp Glu Lys 
            900                 905                 910         


Lys Ile Gln Leu Ala Lys Glu Met Arg Ser Ser Val Asp Ser Glu Ile 
        915                 920                 925             


Gly Gln Thr Glu Ile Arg Ala Met Lys Gly Glu Ile His Arg Met Lys 
    930                 935                 940                 


Lys Tyr Cys Arg Thr Thr Gln Asp Ala His Arg His Val His Glu Gln 
945                 950                 955                 960 


His Gly Thr His Ala Gly Thr Cys Thr Lys Asn Thr Gly Arg Ala Gln 
                965                 970                 975     


Ala Arg Ala Arg Thr Thr Arg Asp Ala Arg Gly His Val His Glu Gln 
            980                 985                 990         


His Gly Thr Arg Ala Gly Thr Cys  Thr Asn Asn Thr Gly  Arg Ala Gln 
        995                 1000                 1005             


Ala Arg  Ala Arg Thr Arg Asp  Ala Arg Arg His Val  His Glu His 
    1010                 1015                 1020             


Arg Thr  His Thr Ala Arg Ala  
    1025                 1030 


<210>  1688
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC42B__Homo_sapiens__NP_001138344

<400>  1688

Met Ala Val Pro Trp Glu Glu Tyr Phe Arg Leu Ala Leu Gln Glu Lys 
1               5                   10                  15      


Leu Ser Thr Lys Leu Pro Glu Gln Ala Glu Asp His Val Pro Pro Val 
            20                  25                  30          


Leu Arg Leu Leu Glu Lys Arg Gln Glu Leu Val Asp Ala Asp Gln Ala 
        35                  40                  45              


Leu Gln Ala Gln Lys Glu Val Phe Arg Thr Lys Thr Ala Ala Leu Lys 
    50                  55                  60                  


Gln Arg Trp Glu Gln Leu Glu Gln Lys Glu Arg Glu Leu Lys Gly Ser 
65                  70                  75                  80  


Phe Ile Arg Phe Asp Lys Phe Leu Gln Asp Ser Glu Ala Arg Arg Asn 
                85                  90                  95      


Arg Ala Leu Arg Arg Ala Ala Glu Glu Arg His Gln Ala Gly Arg Arg 
            100                 105                 110         


Glu Val Glu Ala Leu Arg Leu Trp Thr Gln Leu Gln Glu Leu Arg Arg 
        115                 120                 125             


Glu His Ala Arg Leu Gln Arg Arg Leu Lys Arg Leu Glu Pro Cys Ala 
    130                 135                 140                 


Arg Leu Leu Glu Gln Ala Leu Glu Leu Leu Pro Gly Phe Gln Glu Val 
145                 150                 155                 160 


Pro Glu Leu Val Ala Arg Phe Asp Gly Leu Ala Glu Thr Gln Ala Ala 
                165                 170                 175     


Leu Arg Leu Arg Glu Arg Glu Gln Leu Ala Glu Leu Glu Ala Ala Arg 
            180                 185                 190         


Ala Arg Leu Gln Gln Leu Arg Asp Ala Trp Pro Asp Glu Val Leu Ala 
        195                 200                 205             


Gln Gly Gln Arg Arg Ala Gln Leu Gln Glu Arg Leu Glu Ala Ala Arg 
    210                 215                 220                 


Glu Arg Thr Leu Gln Trp Glu Ser Lys Trp Ile Gln Ile Gln Asn Thr 
225                 230                 235                 240 


Ala Ala Glu Lys Thr Leu Leu Leu Gly Arg Ser Arg Met Ala Val Leu 
                245                 250                 255     


Asn Leu Phe Gln Leu Val Cys Gln His Gln Gly Gln Pro Pro Thr Leu 
            260                 265                 270         


Asp Ile Glu Asp Thr Glu Gly Gln Leu Glu His Val Lys Leu Phe Met 
        275                 280                 285             


Gln Asp Leu Ser Ala Met Leu Ala Gly Leu Gly Gln Ala Glu Pro Ala 
    290                 295                 300                 


Ala Pro Ala Ser 
305             


<210>  1689
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC42__Homo_sapiens__NP_001151733

<400>  1689

Met Ser Leu Gly Ile Met Glu Glu Glu Asp Leu Ala Glu Tyr Phe Arg 
1               5                   10                  15      


Leu Gln Tyr Gly Glu Arg Leu Leu Gln Met Leu Gln Lys Leu Pro Asn 
            20                  25                  30          


Val Glu Gly Ala Ser Glu Ser Pro Ser Ile Trp Leu Leu Glu Lys Lys 
        35                  40                  45              


Lys Glu Thr Glu Ile Met His Gln Thr Met Val Gln Lys Lys Lys Met 
    50                  55                  60                  


Phe Gln Arg Arg Met Glu Thr Leu Asn Leu Arg Trp Glu Glu Leu Gly 
65                  70                  75                  80  


Val Lys Glu Ala Gln Leu Lys Ala His Ile Gln Lys Ser Glu Gln Phe 
                85                  90                  95      


Ile Gln Glu Asn Asp Gln Lys Arg Ile Arg Ala Met Lys Lys Ala Asn 
            100                 105                 110         


Lys Glu Arg Glu Leu Lys Cys Gln His Met Gln Glu Leu Thr Lys Arg 
        115                 120                 125             


Lys Gln Glu Met Val Ala Leu Arg Leu Glu His Gln Arg Leu Ser Ala 
    130                 135                 140                 


Lys Leu Lys Asp Tyr Tyr Ile Phe Asn Lys Tyr Leu Glu Lys Val Val 
145                 150                 155                 160 


Glu Asn Ser Glu Glu Ser Arg Trp Ala His Ile Gln Asn Thr Ala Ala 
                165                 170                 175     


Lys Lys Thr Leu Leu Leu Gly Thr Ile Lys Met Ala Thr Leu Asn Leu 
            180                 185                 190         


Phe Gln Ile Val Ser Lys His Leu Lys Glu Val Thr Glu Val Ala Leu 
        195                 200                 205             


Glu Asp Thr His Lys Gln Leu Asp Met Ile Gln Gln Phe Ile Gln Asp 
    210                 215                 220                 


Arg Ser Asp Ile Trp Ala Glu Val Lys Lys Lys Glu Gln Gln Arg Val 
225                 230                 235                 240 


Arg Ile 
        


<210>  1690
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC50__Homo_sapiens__NP_777568

<400>  1690

Met Ala Glu Val Ser Ile Asp Gln Ser Lys Leu Pro Gly Val Lys Glu 
1               5                   10                  15      


Val Cys Arg Asp Phe Ala Val Leu Glu Asp His Thr Leu Ala His Ser 
            20                  25                  30          


Leu Gln Glu Gln Glu Ile Glu His His Leu Ala Ser Asn Val Gln Arg 
        35                  40                  45              


Asn Arg Leu Val Gln His Asp Leu Gln Val Ala Lys Gln Leu Gln Glu 
    50                  55                  60                  


Glu Asp Leu Lys Ala Gln Ala Gln Leu Gln Lys Arg Tyr Lys Asp Leu 
65                  70                  75                  80  


Glu Gln Gln Asp Cys Glu Ile Ala Gln Glu Ile Gln Glu Lys Leu Ala 
                85                  90                  95      


Ile Glu Ala Glu Arg Arg Arg Ile Gln Glu Lys Lys Asp Glu Asp Ile 
            100                 105                 110         


Ala Arg Leu Leu Gln Glu Lys Glu Leu Gln Glu Glu Lys Lys Arg Lys 
        115                 120                 125             


Lys His Phe Pro Glu Phe Pro Ala Thr Arg Ala Tyr Ala Asp Ser Tyr 
    130                 135                 140                 


Tyr Tyr Glu Asp Gly Gly Met Lys Pro Arg Val Met Lys Glu Ala Val 
145                 150                 155                 160 


Ser Thr Pro Ser Arg Met Ala His Arg Asp Gln Glu Trp Tyr Asp Ala 
                165                 170                 175     


Glu Ile Ala Arg Lys Leu Gln Glu Glu Glu Leu Leu Ala Thr Gln Val 
            180                 185                 190         


Asp Met Arg Ala Ala Gln Val Ala Gln Asp Glu Glu Ile Ala Arg Leu 
        195                 200                 205             


Leu Met Ala Glu Glu Lys Lys Ala Tyr Lys Lys Ala Lys Glu Arg Glu 
    210                 215                 220                 


Lys Ser Ser Leu Asp Lys Arg Lys Gln Asp Pro Glu Trp Lys Pro Lys 
225                 230                 235                 240 


Thr Ala Lys Ala Ala Asn Ser Lys Ser Lys Glu Ser Asp Glu Pro His 
                245                 250                 255     


His Ser Lys Asn Glu Arg Pro Ala Arg Pro Pro Pro Pro Ile Met Thr 
            260                 265                 270         


Asp Gly Glu Asp Ala Asp Tyr Thr His Phe Thr Asn Gln Gln Ser Ser 
        275                 280                 285             


Thr Arg His Phe Ser Lys Ser Glu Ser Ser His Lys Gly Phe His Tyr 
    290                 295                 300                 


Lys His 
305     


<210>  1691
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC54__Homo_sapiens__NP_115989

<400>  1691

Met Tyr Thr Leu His Thr Lys Arg Val Lys Ala Ala Ala Arg Gln Met 
1               5                   10                  15      


Trp Thr Ser Asn Leu Ser Lys Val Arg Gln Ser Leu Lys Asn Val Tyr 
            20                  25                  30          


His Lys Cys Lys Ile Arg His Gln Asp Ser Thr Gly Tyr Pro Thr Val 
        35                  40                  45              


Thr Ser Asp Asp Cys Asn Gln Asp Asp Asp Ser Tyr Asp Gly Lys Met 
    50                  55                  60                  


Asn Leu Pro Val Val Leu Gln Asp Val Lys Thr Ala Gln Val Glu Leu 
65                  70                  75                  80  


Phe Ser Gln Met Thr Asp Ile Val His Met Ile Pro Lys Val Gln Glu 
                85                  90                  95      


Lys Thr Asp Leu Tyr Gln Lys Gln Met Glu Val Leu Glu Thr Arg Met 
            100                 105                 110         


Asn Val Asn Glu Asp Lys Gln Cys Thr Thr Thr Lys Asp Ile Leu Ser 
        115                 120                 125             


Met Lys Glu Asp Ile Lys Ala Leu Lys Lys Lys Val Thr Glu Leu Glu 
    130                 135                 140                 


Ile Gln Asn Ser Cys Ser Thr Ile His Cys Leu Glu Ile Leu Glu Gly 
145                 150                 155                 160 


Glu Arg Gly Lys Glu Ile Thr Glu Leu Leu Tyr Lys Leu Ile Gln Pro 
                165                 170                 175     


Ala Thr Leu Lys Asn Thr Leu Ala Ser Thr Asp Met Glu Ile Ser Ser 
            180                 185                 190         


Ala Glu Pro Glu Lys Val Pro Ser Tyr Pro Lys Ser Thr Asp His Leu 
        195                 200                 205             


Glu Lys Lys Thr Ile Ser Pro Gln Met Lys Thr Leu Lys Lys Arg Asn 
    210                 215                 220                 


His Gln Asn Ala Ser Arg Ser Phe Glu Lys Ala Lys Pro Asn Ile Tyr 
225                 230                 235                 240 


Ile Tyr Pro Asp Phe Ser Thr Trp Ile Lys Leu Thr Phe Val His Gly 
                245                 250                 255     


Gly Lys Trp Thr Phe Phe Leu Ser Ala Thr Lys Leu Glu Glu Phe Ile 
            260                 265                 270         


Gln Trp Leu Leu Ser Arg Pro Thr Ile Leu Pro Glu Glu Pro Gln Val 
        275                 280                 285             


Ile Thr Gln Arg Tyr Cys Pro Phe Thr Gly Pro Ile Leu Ser Leu Thr 
    290                 295                 300                 


Thr Ile Cys Leu Ser Ile Phe Asn Asn Ile Tyr Gly Phe Ile Cys Ser 
305                 310                 315                 320 


Leu Lys Glu Glu Val Thr Arg Leu 
                325             


<210>  1692
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC60__Homo_sapiens__NP_848594

<400>  1692

Met Thr Lys Val Pro Ala Thr Lys Lys Leu Gln Ser Ser Pro Asn Ser 
1               5                   10                  15      


Gly Ala Val Arg Pro Phe Tyr Ala Ser Glu Asn Leu Arg Gln Val Pro 
            20                  25                  30          


Asp Lys Pro Met Lys Ser Ile Lys Tyr Met Asp Lys Glu Ile Ile Asn 
        35                  40                  45              


Leu Lys Lys Asp Leu Ile Arg Ser Arg Phe Leu Ile Gln Ser Val Lys 
    50                  55                  60                  


Ile Gly Arg Gly Tyr Phe Ala Ile Leu Arg Glu Glu Thr Ala Lys Lys 
65                  70                  75                  80  


Lys Lys Gln Gln Gln Leu Gln Lys Leu Lys Glu Glu Glu Arg Asn Lys 
                85                  90                  95      


Phe Gln Pro Ala Glu Lys Ile Ser Glu Ile His Tyr Gly Asp Thr Leu 
            100                 105                 110         


Leu Ser Thr Tyr Asp Asp Glu Lys Leu Lys Thr Leu Gly Ala Arg Val 
        115                 120                 125             


Thr Arg Arg Pro Phe Thr Pro Ile His Ser Cys Ile Ile Ser Pro Ser 
    130                 135                 140                 


Leu Thr Glu Ala His Val Glu Pro Leu Phe Arg Gln Leu Cys Ala Leu 
145                 150                 155                 160 


His Trp Leu Leu Glu Ala Leu Thr Ile Asp His Thr His His Thr Met 
                165                 170                 175     


Lys Pro Val Ile Thr Cys Trp Asn Pro Lys Asp Pro Gly Gly Ser Lys 
            180                 185                 190         


Ser Thr Ile Lys Lys Ile Asn Lys Asp Lys Ser Met Gly Gln Lys Trp 
        195                 200                 205             


Glu His Phe Ile Thr Ala Pro Lys Thr Lys Lys Phe Lys Ile Pro Thr 
    210                 215                 220                 


Met Arg Val Thr Asn Arg Lys Pro Ser Arg Arg Gly Ser Thr Leu Ser 
225                 230                 235                 240 


Leu Ser Arg Ala Ser Gly Gly Ser Ser Pro Gln Ser Ser Met Ile Ser 
                245                 250                 255     


Val Asn Pro Gly Ser Asp Glu Pro Pro Ser Val Asn Thr Gln Val Thr 
            260                 265                 270         


Ser Ser Lys Asp Ile Glu Asp Asn Glu Ser Ser Ser Thr Lys Pro Asp 
        275                 280                 285             


Glu Glu Pro Leu Tyr Met Asn Leu Gln Lys Leu Leu Glu Met Val Arg 
    290                 295                 300                 


Glu Asp Ala Arg Arg Thr Val Thr Ile Glu Asn Gly Met Gln Arg Lys 
305                 310                 315                 320 


Ala Pro Ser Ile Leu Ser Val Leu Lys Gln Asn Lys Ser Asn Ser Ala 
                325                 330                 335     


Tyr Lys Glu Met Gln Thr Thr Leu Lys Ser Ser Glu Arg Ser Ser Ser 
            340                 345                 350         


Thr Ser Ala Glu Ser His Ile Gln Pro Val Gln Lys Lys Ser Lys Asn 
        355                 360                 365             


Arg Thr Asn Cys Asp Ile Asn Ile His Tyr Lys Ser Gly Val Cys Asn 
    370                 375                 380                 


Thr Met Arg Ala Lys Phe Tyr Ser Val Ala Gln Glu Ala Gly Phe Cys 
385                 390                 395                 400 


Leu Gln Asp Lys Met Glu Ile Leu Met Lys Arg Gln Glu Glu Arg Gly 
                405                 410                 415     


Ile Gln Lys Phe Arg Ala Phe Val Leu Val Ser Asn Phe Gln Lys Asp 
            420                 425                 430         


Ile Ala Lys Met Arg His His Ile Ser Val Val Lys Gly Asp Ala Glu 
        435                 440                 445             


Glu Ile Ala Asp His Trp Tyr Phe Asp Leu Leu Ser Lys Leu Pro Glu 
    450                 455                 460                 


Asp Leu Lys Asn Phe Arg Pro Ala Lys Lys Ile Leu Val Lys Leu Gln 
465                 470                 475                 480 


Lys Phe Gly Glu Asn Leu Asp Leu Arg Ile Arg Pro His Val Leu Leu 
                485                 490                 495     


Lys Val Leu Gln Asp Leu Arg Ile Trp Glu Leu Cys Ser Pro Asp Ile 
            500                 505                 510         


Ala Val Ala Ile Glu Phe Val Arg Glu His Ile Ile His Met Pro Gln 
        515                 520                 525             


Glu Asp Tyr Ile Ser Trp Leu Gln Ser Arg Ile Asn Ile Pro Ile Gly 
    530                 535                 540                 


Pro Tyr Ser Ala Leu Arg 
545                 550 


<210>  1693
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC62__Homo_sapiens__NP_958843

<400>  1693

Met Asn Pro Pro Ala Ala Phe Leu Ala Gly Arg Gln Asn Ile Gly Ser 
1               5                   10                  15      


Glu Val Glu Ile Ser Thr Ile Glu Lys Gln Arg Lys Glu Leu Gln Leu 
            20                  25                  30          


Leu Ile Gly Glu Leu Lys Asp Arg Asp Lys Glu Leu Asn Asp Met Val 
        35                  40                  45              


Ala Val His Gln Gln Gln Leu Leu Ser Trp Glu Glu Asp Arg Gln Lys 
    50                  55                  60                  


Val Leu Thr Leu Glu Glu Arg Cys Ser Lys Leu Glu Gly Glu Leu His 
65                  70                  75                  80  


Lys Arg Thr Glu Ile Ile Arg Ser Leu Thr Lys Lys Val Lys Ala Leu 
                85                  90                  95      


Glu Ser Asn Gln Met Glu Cys Gln Thr Ala Leu Gln Lys Thr Gln Leu 
            100                 105                 110         


Gln Leu Gln Glu Met Ala Gln Lys Ala Thr His Ser Ser Leu Leu Ser 
        115                 120                 125             


Glu Asp Leu Glu Ala Arg Asn Glu Thr Leu Ser Asn Thr Leu Val Glu 
    130                 135                 140                 


Leu Ser Ala Gln Val Gly Gln Leu Gln Ala Arg Glu Gln Ala Leu Thr 
145                 150                 155                 160 


Thr Met Ile Lys Leu Lys Asp Lys Asp Ile Ile Glu Ala Val Asn His 
                165                 170                 175     


Ile Ala Asp Cys Ser Gly Lys Phe Lys Met Leu Glu His Ala Leu Arg 
            180                 185                 190         


Asp Ala Lys Met Ala Glu Thr Cys Ile Val Lys Glu Lys Gln Asp Tyr 
        195                 200                 205             


Lys Gln Lys Leu Lys Ala Leu Lys Ile Glu Val Asn Lys Leu Lys Glu 
    210                 215                 220                 


Asp Leu Asn Glu Lys Thr Thr Glu Asn Asn Glu Gln Arg Glu Glu Ile 
225                 230                 235                 240 


Ile Arg Leu Lys Gln Glu Lys Ser Cys Leu His Asp Glu Leu Leu Phe 
                245                 250                 255     


Thr Val Glu Arg Glu Lys Arg Lys Asp Glu Leu Leu Asn Ile Ala Lys 
            260                 265                 270         


Ser Lys Gln Glu Arg Thr Asn Ser Glu Leu His Asn Leu Arg Gln Ile 
        275                 280                 285             


Tyr Val Lys Gln Gln Ser Asp Leu Gln Phe Leu Asn Phe Asn Val Glu 
    290                 295                 300                 


Asn Ser Gln Glu Leu Ile Gln Met Tyr Asp Ser Lys Met Glu Glu Ser 
305                 310                 315                 320 


Lys Ala Leu Asp Ser Ser Arg Asp Met Cys Leu Ser Asp Leu Glu Asn 
                325                 330                 335     


Asn His Pro Lys Val Asp Ile Lys Arg Glu Lys Asn Gln Lys Ser Leu 
            340                 345                 350         


Phe Lys Asp Gln Lys Phe Glu Ala Met Leu Val Gln Gln Asn Arg Ser 
        355                 360                 365             


Asp Lys Ser Ser Cys Asp Glu Cys Lys Glu Lys Lys Gln Gln Ile Asp 
    370                 375                 380                 


Thr Val Phe Gly Glu Lys Ser Val Ile Thr Leu Ser Ser Ile Phe Thr 
385                 390                 395                 400 


Lys Asp Leu Val Glu Lys His Asn Leu Pro Trp Ser Leu Gly Gly Lys 
                405                 410                 415     


Thr Gln Ile Glu Pro Glu Asn Lys Ile Thr Leu Cys Lys Ile His Thr 
            420                 425                 430         


Lys Ser Pro Lys Cys His Gly Thr Gly Val Gln Asn Glu Gly Lys Gln 
        435                 440                 445             


Pro Ser Glu Thr Pro Thr Leu Ser Asp Glu Lys Gln Trp His Asp Val 
    450                 455                 460                 


Ser Val Tyr Leu Gly Leu Thr Asn Cys Pro Ser Ser Lys His Pro Glu 
465                 470                 475                 480 


Lys Leu Asp Val Glu Cys Gln Asp Gln Met Glu Arg Ser Glu Ile Ser 
                485                 490                 495     


Cys Cys Gln Lys Asn Glu Ala Cys Leu Gly Glu Ser Gly Met Cys Asp 
            500                 505                 510         


Ser Lys Cys Cys His Pro Ser Asn Phe Ile Ile Glu Ala Pro Gly His 
        515                 520                 525             


Met Ser Asp Val Glu Trp Met Ser Ile Phe Lys Pro Ser Lys Met Gln 
    530                 535                 540                 


Arg Ile Val Arg Leu Lys Ser Gly Cys Thr Cys Ser Glu Ser Ile Cys 
545                 550                 555                 560 


Gly Thr Gln His Asp Ser Pro Ala Ser Glu Leu Ile Ala Ile Gln Asp 
                565                 570                 575     


Ser His Ser Leu Gly Ser Ser Lys Ser Ala Leu Arg Glu Asp Glu Thr 
            580                 585                 590         


Glu Ser Ser Ser Asn Lys Lys Asn Ser Pro Thr Ser Leu Leu Ile Tyr 
        595                 600                 605             


Lys Asp Ala Pro Ala Phe Asn Glu Lys Ala Ser Ile Val Leu Pro Ser 
    610                 615                 620                 


Gln Asp Asp Phe Ser Pro Thr Ser Lys Leu Gln Arg Leu Leu Ala Glu 
625                 630                 635                 640 


Ser Arg Gln Met Val Thr Asp Leu Glu Leu Ser Thr Leu Leu Pro Ile 
                645                 650                 655     


Ser His Glu Asn Leu Thr Gly Ser Ala Thr Asn Lys Ser Glu Val Pro 
            660                 665                 670         


Glu Glu Ser Ala Gln Lys Asn Thr Phe Val Ser Tyr 
        675                 680                 


<210>  1694
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC63__Homo_sapiens__XP_011536303

<400>  1694

Met Ser Val Leu Lys Lys Asn Arg Arg Lys Asp Ser Asp Thr Pro Gln 
1               5                   10                  15      


Glu Pro Ser Glu Lys Ala Lys Glu Gln Gln Ala Glu Ala Glu Leu Arg 
            20                  25                  30          


Lys Leu Arg Gln Gln Phe Arg Lys Met Val Glu Ser Arg Lys Ser Phe 
        35                  40                  45              


Lys Phe Arg Asn Gln Gln Lys Ile Ala Ser Gln Tyr Lys Glu Ile Lys 
    50                  55                  60                  


Thr Leu Lys Thr Glu Gln Asp Glu Ile Thr Leu Leu Leu Ser Leu Met 
65                  70                  75                  80  


Lys Ser Ser Arg Asn Met Asn Arg Ser Glu Lys Asn Tyr Met Glu Leu 
                85                  90                  95      


Arg Leu Leu Leu Gln Thr Lys Glu Asp Tyr Glu Ala Leu Ile Lys Ser 
            100                 105                 110         


Leu Lys Val Leu Leu Ala Glu Leu Asp Glu Lys Ile Leu Gln Met Glu 
        115                 120                 125             


Lys Lys Ile Ala Asn Gln Lys Gln Ile Phe Ala Lys Met Gln Glu Ala 
    130                 135                 140                 


Asn Asn Pro Arg Lys Leu Gln Lys Gln Ile His Ile Leu Glu Thr Arg 
145                 150                 155                 160 


Leu Asn Leu Val Thr Val His Phe Asp Lys Met Leu Thr Thr Asn Ala 
                165                 170                 175     


Lys Leu Arg Lys Glu Ile Glu Asp Leu Arg Phe Glu Lys Ala Ala Tyr 
            180                 185                 190         


Asp Asn Val Tyr Gln Gln Leu Gln His Cys Leu Leu Met Glu Lys Lys 
        195                 200                 205             


Thr Met Asn Leu Ala Ile Glu Gln Ser Ser Gln Ala Tyr Glu Gln Arg 
    210                 215                 220                 


Val Glu Ala Met Ala Arg Met Ala Ala Met Lys Asp Arg Gln Lys Lys 
225                 230                 235                 240 


Asp Thr Ser Gln Tyr Asn Leu Glu Ile Arg Glu Leu Glu Arg Leu Tyr 
                245                 250                 255     


Ala His Glu Ser Lys Leu Lys Ser Phe Leu Leu Val Lys Leu Asn Asp 
            260                 265                 270         


Arg Asn Glu Phe Glu Glu Gln Ala Lys Arg Glu Glu Ala Leu Lys Ala 
        275                 280                 285             


Lys Lys His Val Lys Lys Asn Arg Gly Glu Ser Phe Glu Ser Tyr Glu 
    290                 295                 300                 


Val Ala His Leu Arg Leu Leu Lys Leu Ala Glu Ser Gly Asn Leu Asn 
305                 310                 315                 320 


Gln Leu Ile Glu Asp Phe Leu Ala Lys Glu Glu Lys Asn Phe Ala Arg 
                325                 330                 335     


Phe Thr Tyr Val Thr Glu Leu Asn Asn Asp Met Glu Met Met His Lys 
            340                 345                 350         


Arg Thr Gln Arg Ile Gln Asp Glu Ile Ile Leu Leu Arg Ser Gln Gln 
        355                 360                 365             


Lys Leu Ser His Asp Asp Asn His Ser Val Leu Arg Gln Leu Glu Asp 
    370                 375                 380                 


Lys Leu Arg Lys Thr Thr Glu Glu Ala Asp Met Tyr Glu Ser Lys Tyr 
385                 390                 395                 400 


Gly Glu Val Ser Lys Thr Leu Asp Leu Leu Lys Asn Ser Val Glu Lys 
                405                 410                 415     


Leu Phe Lys Lys Ile Asn Cys Asp Ala Thr Lys Ile Leu Val Gln Leu 
            420                 425                 430         


Gly Glu Thr Gly Lys Val Thr Asp Ile Asn Leu Pro Gln Tyr Phe Ala 
        435                 440                 445             


Ile Ile Glu Lys Lys Thr Asn Asp Leu Leu Leu Leu Glu Thr Tyr Arg 
    450                 455                 460                 


Arg Ile Leu Glu Val Glu Gly Ala Glu Ala Glu Ile Pro Pro Pro Phe 
465                 470                 475                 480 


Ile Asn Pro Phe Trp Gly Gly Ser Ala Leu Leu Lys Pro Pro Glu Pro 
                485                 490                 495     


Ile Lys Val Ile Pro Pro Val Leu Gly Ala Asp Pro Phe Ser Asp Arg 
            500                 505                 510         


Leu Asp Asp Val Glu Gln Pro Leu Asp His Ser Ser Leu Arg Gln Leu 
        515                 520                 525             


Val Leu Asp Asn Tyr Ile Leu Lys Glu Asn Arg Ser Lys Glu Val Arg 
    530                 535                 540                 


Gly Asp Ser Leu Pro Glu Lys Val Asp Asp Phe Arg Ser Arg Lys Lys 
545                 550                 555                 560 


Val Thr Met 
            


<210>  1695
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC65__Homo_sapiens__NP_149115

<400>  1695

Met Pro Lys Lys Glu Lys Met Ala Lys Thr Pro Leu Ser Asp Glu Lys 
1               5                   10                  15      


Gln Leu Leu Leu Phe Gln Gln Lys Leu Leu Ala Glu Glu Glu Met Ala 
            20                  25                  30          


Lys Lys Lys Glu Arg Leu Leu Ser Gln Phe Leu Lys Asp Lys Leu Ala 
        35                  40                  45              


Lys Glu Glu His Asn Ser Ala Leu Asn Leu Asn Lys Ile Asn Thr Gln 
    50                  55                  60                  


Trp Arg Thr Val Leu Arg Glu Val Lys Thr Arg Glu Leu His Lys Asp 
65                  70                  75                  80  


Ile Glu Ile Leu Ser Gln Thr Phe Glu Arg Val Val Asp Cys Lys Asp 
                85                  90                  95      


Asn Val Ile Lys Ser Leu Ala Lys Asp Leu Ser Glu Ala Glu Glu Gln 
            100                 105                 110         


Tyr Ala His Ala Leu Arg Ser His Leu His Asn Val Asp Gln Leu Leu 
        115                 120                 125             


Ala Leu Gln Arg His Arg Leu Ser Leu Leu Glu Glu Ser Tyr Asn Met 
    130                 135                 140                 


Glu Leu Glu Ala Leu Thr Lys Glu Phe Glu Thr Glu Arg Lys Thr Ile 
145                 150                 155                 160 


Ile Asp Gln His Glu Lys Glu Ile His Tyr Leu Gln Asp Ile Phe Met 
                165                 170                 175     


Ala Met Glu Gln Asn Tyr Ile Asp Ser Glu Tyr Glu Ser Lys Leu Glu 
            180                 185                 190         


Phe Gln Ser Met Trp Asn Asp Leu Lys Asn Met Asn Leu Glu Glu Lys 
        195                 200                 205             


His Phe Leu Arg Leu His Leu Glu Asn Arg Val Glu Asp Leu Trp Arg 
    210                 215                 220                 


Lys Phe Gln Asp Val Leu Lys Asn Tyr Thr Asp Ala Thr Glu Asp Arg 
225                 230                 235                 240 


Lys Ala Ala Phe Glu Thr Leu Gln Val Lys Asp Glu Lys Ser Ser Lys 
                245                 250                 255     


Glu Ile Glu Val Gln Met Lys Lys Ile Gln Lys Leu Gln Asp Ala Ile 
            260                 265                 270         


Thr Ile Ser Lys Gly Lys Ile Met Ile His Ser Arg Glu Ser Glu Asp 
        275                 280                 285             


Glu Asn Arg Tyr Ile Arg Asn Asp Lys Glu Leu Val Leu Val Gln Leu 
    290                 295                 300                 


Arg Lys Leu Lys Ala Gln Arg Thr Gln Ala Arg Ala Ala Ser Gln Lys 
305                 310                 315                 320 


Asn Leu Val Arg Leu Thr Leu Glu Ser Asn Ala Thr Leu Lys Ala Leu 
                325                 330                 335     


Arg Lys Ile Val Asp Lys Gly Glu Lys Ile Leu Lys Leu Ala Glu Ile 
            340                 345                 350         


Cys Arg Lys Phe Glu Thr Glu Glu Glu Lys Val Leu Pro Phe Tyr Ser 
        355                 360                 365             


Ser Val Leu Thr Pro Lys Glu Gln Glu Gly Ile Gln Lys Asn Asn Leu 
    370                 375                 380                 


Glu Glu Leu Thr Glu Glu Leu Thr Lys Val Met Val Asp Tyr Ile Gly 
385                 390                 395                 400 


Met Glu Asn Phe Trp Lys Arg Tyr Asn Lys Val Lys Leu Glu Gln Leu 
                405                 410                 415     


Ser Leu Gln His Arg Arg Ala Gln Leu Leu Asp Ile Asn Gly Lys Leu 
            420                 425                 430         


Arg Glu Met Leu Lys Gln Tyr Leu Asp Gly Ile Ser Val Ser Asp Glu 
        435                 440                 445             


Val Leu Ser Gln Leu Asn Pro Leu Phe Ile Val Asn Tyr Gln Ser Asn 
    450                 455                 460                 


Leu Leu Gln Pro Leu Ser Ile Arg Ile Ala His Pro Gly Asp Lys Gln 
465                 470                 475                 480 


His Pro Thr Thr 
                


<210>  1696
<211>  914
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC66__Homo_sapiens__NP_001012524

<400>  1696

Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr Lys Thr 
1               5                   10                  15      


Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser Glu Lys 
            20                  25                  30          


Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala Lys Gly 
        35                  40                  45              


Glu Lys Asn Gly Met Thr Phe Ser Ser Thr Lys Asp Leu Cys Lys Gln 
    50                  55                  60                  


Cys Ile Asp Lys Asp Cys Leu His Ile Gln Lys Glu Ile Ser Pro Ala 
65                  70                  75                  80  


Thr Pro Asn Met Gln Lys Thr Arg Asn Thr Val Asn Thr Ser Leu Val 
                85                  90                  95      


Gly Lys Gln Lys Pro His Lys Lys His Ile Thr Ala Glu Asn Met Lys 
            100                 105                 110         


Ser Ser Leu Val Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile Leu Met 
        115                 120                 125             


Thr Val Asn Gln Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn Gly Lys 
    130                 135                 140                 


Glu Ala Lys Ser Gln Tyr Ser Leu Tyr Leu Asn Ser Ile Ser Asn Gln 
145                 150                 155                 160 


Pro Lys Asp Glu Asn Ile Met Gly Leu Phe Lys Lys Thr Glu Met Val 
                165                 170                 175     


Ser Ser Val Pro Ala Glu Asn Lys Ser Val Leu Asn Glu His Gln Glu 
            180                 185                 190         


Thr Ser Lys Gln Cys Glu Gln Lys Ile Ala Ile Glu Asn Glu Trp Lys 
        195                 200                 205             


Pro Ala Asp Ile Phe Ser Thr Leu Gly Glu Arg Glu Cys Asp Arg Ser 
    210                 215                 220                 


Ser Leu Glu Ala Lys Lys Ala Gln Trp Arg Lys Glu Leu Asp Glu Gln 
225                 230                 235                 240 


Val Ala Leu Lys Lys Lys Glu Lys Glu Val Ser Glu Lys Trp Asn Asp 
                245                 250                 255     


Pro Trp Lys Lys Ser Glu Ser Asp Lys Ile Ile Trp Glu Lys His Gln 
            260                 265                 270         


Ile Leu Asp Gln Ser Arg Glu Thr Val Leu Leu Glu His Pro Phe Ser 
        275                 280                 285             


Ala Val Lys Gln Glu Leu Gln Arg Lys Trp Ile Glu Glu Leu Asn Lys 
    290                 295                 300                 


Gln Ile Glu Asp Asp Arg Gln Arg Lys Ile Glu Glu Lys Ile Ile Tyr 
305                 310                 315                 320 


Ser Lys Gly Glu Glu His Asp Arg Trp Ala Met His Phe Asp Ser Leu 
                325                 330                 335     


Lys Ser Tyr Pro Gly Ser Gln Ser Gln Leu Phe Ser Gln Ser Thr His 
            340                 345                 350         


Lys Gln Pro Glu Tyr Phe Cys Val Ser Pro Asp Thr Gln Glu Leu Ala 
        355                 360                 365             


Asp Val Ser Ser Val Cys Thr Pro Thr Thr Gly Ser Gln Val Glu Pro 
    370                 375                 380                 


Ser Glu Glu Glu His Ile Ala Lys Pro Ile Lys Asp Val Val Met Ala 
385                 390                 395                 400 


Asn Ser Lys Lys Thr Asn Phe Leu Arg Ser Met Thr Ala Leu Leu Asp 
                405                 410                 415     


Pro Ala Gln Ile Glu Glu Arg Asp Arg Arg Arg Gln Lys Gln Leu Glu 
            420                 425                 430         


His Gln Lys Ala Ile Thr Ala Gln Val Glu Glu Lys Arg Arg Lys Lys 
        435                 440                 445             


Gln Leu Glu Glu Glu Gln Arg Lys Lys Glu Glu Gln Glu Glu Glu Leu 
    450                 455                 460                 


Arg Leu Ala Gln Glu Arg Glu Glu Met Gln Lys Gln Tyr Glu Glu Asp 
465                 470                 475                 480 


Ile Leu Lys Gln Lys Gln Lys Glu Glu Ile Met Thr Leu Lys Thr Asn 
                485                 490                 495     


Glu Leu Phe Gln Thr Met Gln Arg Ala Gln Glu Leu Ala Gln Arg Leu 
            500                 505                 510         


Lys Gln Glu Gln Arg Ile Arg Glu Leu Ala Gln Lys Gly His Asp Thr 
        515                 520                 525             


Ser Arg Leu Ile Lys Asn Leu Gly Val Asp Thr Ile Gln Met Glu Tyr 
    530                 535                 540                 


Asn Ala Ser Asn Ile Ser Asn Ser Arg His Asp Ser Asp Glu Ile Ser 
545                 550                 555                 560 


Gly Lys Met Asn Thr Tyr Met Asn Ser Thr Thr Ser Lys Lys Asp Thr 
                565                 570                 575     


Gly Val Gln Thr Asp Asp Leu Asn Ile Gly Ile Phe Thr Asn Ala Glu 
            580                 585                 590         


Ser His Cys Gly Ser Leu Met Glu Arg Asp Ile Thr Asn Cys Ser Ser 
        595                 600                 605             


Pro Glu Ile Ser Ala Glu Leu Ile Gly Gln Phe Ser Thr Lys Lys Asn 
    610                 615                 620                 


Lys Gln Glu Leu Thr Gln Asp Lys Gly Ala Ser Leu Glu Lys Glu Asn 
625                 630                 635                 640 


Asn Arg Cys Asn Asp Gln Cys Asn Gln Phe Thr Arg Ile Glu Lys Gln 
                645                 650                 655     


Thr Lys His Met Lys Lys Tyr Pro Lys Arg Pro Asp Trp Asn Ile Asn 
            660                 665                 670         


Lys Pro Pro Lys Arg Tyr Ile Pro Ala Ser Glu Lys Tyr Pro Lys Gln 
        675                 680                 685             


Leu Gln Lys Gln Arg Glu Glu Lys Lys Val Arg Arg Gln Met Glu Leu 
    690                 695                 700                 


Leu His Leu Val Glu Lys Asn Asn Pro Gly His Leu Ser Gln Asn Arg 
705                 710                 715                 720 


Gly Ile Ser Pro Glu Ile Phe His Ser Ser His Gln Glu Thr Glu Ser 
                725                 730                 735     


Lys Leu Arg Trp His Leu Val Lys Lys Glu Glu Glu Pro Leu Asn Ile 
            740                 745                 750         


His Ser Phe Ser Lys Glu Arg Ser Pro Ser Ser Pro Val Pro Val Val 
        755                 760                 765             


Lys Asn Arg Thr Gln Gln Thr Gln Asn Thr Leu His Leu Pro Leu Lys 
    770                 775                 780                 


Asn Ser Ser Tyr Glu Arg Glu Asn Leu Ile Ser Gly Ser Asn Gln Thr 
785                 790                 795                 800 


Glu Leu Ser Ser Gly Ile Ser Glu Ser Ser His Phe Ile Pro Tyr Val 
                805                 810                 815     


Arg Thr Asn Glu Ile Tyr Tyr Leu Asp Pro Asp Ala Pro Leu Ser Gly 
            820                 825                 830         


Pro Ser Thr Gln Asp Pro Gln Tyr Gln Asn Ser Gln Asp Cys Gly Gln 
        835                 840                 845             


Lys Arg Gln Leu Phe Asp Ser Asp Cys Val Arg Asp Pro Leu Leu Asn 
    850                 855                 860                 


Pro Asn Met Val Lys Asn Arg Asp Arg Gln Gln Ala Ile Leu Lys Gly 
865                 870                 875                 880 


Leu Ser Glu Leu Arg Gln Gly Leu Leu Gln Lys Gln Lys Glu Leu Glu 
                885                 890                 895     


Ser Ser Leu Leu Pro Leu Ala Glu Asn Gln Glu Glu Ser Phe Gly Ser 
            900                 905                 910         


Ser Phe 
        


<210>  1697
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC67__Homo_sapiens__NP_857596

<400>  1697

Met Glu Asn Gln Ala His Asn Thr Met Gly Thr Ser Pro Cys Glu Ala 
1               5                   10                  15      


Glu Leu Gln Glu Leu Met Glu Gln Ile Asp Ile Met Val Ser Asn Lys 
            20                  25                  30          


Lys Met Asp Trp Glu Arg Lys Met Arg Ala Leu Glu Thr Arg Leu Asp 
        35                  40                  45              


Leu Arg Asp Gln Glu Leu Ala Asn Ala Gln Thr Cys Leu Asp Gln Lys 
    50                  55                  60                  


Gly Gln Glu Val Gly Leu Leu Arg Gln Lys Leu Asp Ser Leu Glu Lys 
65                  70                  75                  80  


Cys Asn Leu Ala Met Thr Gln Asn Tyr Glu Gly Gln Leu Gln Ser Leu 
                85                  90                  95      


Lys Ala Gln Phe Ser Lys Leu Thr Asn Asn Phe Glu Lys Leu Arg Leu 
            100                 105                 110         


His Gln Met Lys Gln Asn Lys Val Pro Arg Lys Glu Leu Pro His Leu 
        115                 120                 125             


Lys Glu Glu Ile Pro Phe Glu Leu Ser Asn Leu Asn Gln Lys Leu Glu 
    130                 135                 140                 


Glu Phe Arg Ala Lys Ser Arg Glu Trp Asp Lys Gln Glu Ile Leu Tyr 
145                 150                 155                 160 


Gln Thr His Leu Ile Ser Leu Asp Ala Gln Gln Lys Leu Leu Ser Glu 
                165                 170                 175     


Lys Cys Asn Gln Phe Gln Lys Gln Ala Gln Ser Tyr Gln Thr Gln Leu 
            180                 185                 190         


Asn Gly Lys Lys Gln Cys Leu Glu Asp Ser Ser Ser Glu Ile Pro Arg 
        195                 200                 205             


Leu Ile Cys Asp Pro Asp Pro Asn Cys Glu Ile Asn Glu Arg Asp Glu 
    210                 215                 220                 


Phe Ile Ile Glu Lys Leu Lys Ser Ala Val Asn Glu Ile Ala Leu Ser 
225                 230                 235                 240 


Arg Asn Lys Leu Gln Asp Glu Asn Gln Lys Leu Leu Gln Glu Leu Lys 
                245                 250                 255     


Met Tyr Gln Arg Gln Cys Gln Ala Met Glu Ala Gly Leu Ser Glu Val 
            260                 265                 270         


Lys Ser Glu Leu Gln Ser Arg Asp Asp Leu Leu Arg Ile Ile Glu Met 
        275                 280                 285             


Glu Arg Leu Gln Leu His Arg Glu Leu Leu Lys Ile Gly Glu Cys Gln 
    290                 295                 300                 


Asn Ala Gln Gly Asn Lys Thr Arg Leu Glu Ser Ser Tyr Leu Pro Ser 
305                 310                 315                 320 


Ile Lys Glu Pro Glu Arg Lys Ile Lys Glu Leu Phe Ser Val Met Gln 
                325                 330                 335     


Asp Gln Pro Asn His Glu Lys Glu Leu Asn Lys Ile Arg Ser Gln Leu 
            340                 345                 350         


Gln Gln Val Glu Glu Tyr His Asn Ser Glu Gln Glu Arg Met Arg Asn 
        355                 360                 365             


Glu Ile Ser Asp Leu Thr Glu Glu Leu His Gln Lys Glu Ile Thr Ile 
    370                 375                 380                 


Ala Thr Val Thr Lys Lys Ala Ala Leu Leu Glu Lys Gln Leu Lys Met 
385                 390                 395                 400 


Glu Leu Glu Ile Lys Glu Lys Met Leu Ala Lys Gln Lys Val Ser Asp 
                405                 410                 415     


Met Lys Tyr Lys Ala Val Arg Thr Glu Asn Thr His Leu Lys Gly Met 
            420                 425                 430         


Met Gly Asp Leu Asp Pro Gly Glu Tyr Met Ser Met Asp Phe Thr Asn 
        435                 440                 445             


Arg Glu Gln Ser Arg His Thr Ser Ile Asn Lys Leu Gln Tyr Glu Asn 
    450                 455                 460                 


Glu Arg Leu Arg Asn Asp Leu Ala Lys Leu His Val Asn Gly Lys Ser 
465                 470                 475                 480 


Thr Trp Thr Asn Gln Asn Thr Tyr Glu Glu Thr Gly Arg Tyr Ala Tyr 
                485                 490                 495     


Gln Ser Gln Ile Lys Val Glu Gln Asn Glu Glu Arg Leu Ser His Asp 
            500                 505                 510         


Cys Glu Pro Asn Arg Ser Thr Met Pro Pro Leu Pro Pro Ser Thr Phe 
        515                 520                 525             


Gln Ala Lys Glu Met Thr Ser Pro Leu Val Ser Asp Asp Asp Val Phe 
    530                 535                 540                 


Pro Leu Ser Pro Pro Asp Met Ser Phe Pro Ala Ser Leu Ala Ala Gln 
545                 550                 555                 560 


His Phe Leu Leu Glu Glu Glu Lys Arg Ala Lys Glu Leu Glu Lys Leu 
                565                 570                 575     


Leu Asn Thr His Ile Asp Glu Leu Gln Arg His Thr Glu Phe Thr Leu 
            580                 585                 590         


Asn Lys Tyr Ser Lys Leu Lys Gln Asn Arg His Ile 
        595                 600                 


<210>  1698
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC68__Homo_sapiens__NP_001137301

<400>  1698

Met Thr Thr Val Thr Val Thr Thr Glu Ile Pro Pro Arg Asp Lys Met 
1               5                   10                  15      


Glu Asp Asn Ser Ala Leu Tyr Glu Ser Thr Ser Ala His Ile Ile Glu 
            20                  25                  30          


Glu Thr Glu Tyr Val Lys Lys Ile Arg Thr Thr Leu Gln Lys Ile Arg 
        35                  40                  45              


Thr Gln Met Phe Lys Asp Glu Ile Arg His Asp Ser Thr Asn His Lys 
    50                  55                  60                  


Leu Asp Ala Lys His Cys Gly Asn Leu Gln Gln Gly Ser Asp Ser Glu 
65                  70                  75                  80  


Met Asp Pro Ser Cys Cys Ser Leu Asp Leu Leu Met Lys Lys Ile Lys 
                85                  90                  95      


Gly Lys Asp Leu Gln Leu Leu Glu Met Asn Lys Glu Asn Glu Val Leu 
            100                 105                 110         


Lys Ile Lys Leu Gln Ala Ser Arg Glu Ala Gly Ala Ala Ala Leu Arg 
        115                 120                 125             


Asn Val Ala Gln Arg Leu Phe Glu Asn Tyr Gln Thr Gln Ser Glu Glu 
    130                 135                 140                 


Val Arg Lys Lys Gln Glu Asp Ser Lys Gln Leu Leu Gln Val Asn Lys 
145                 150                 155                 160 


Leu Glu Lys Glu Gln Lys Leu Lys Gln His Val Glu Asn Leu Asn Gln 
                165                 170                 175     


Val Ala Glu Lys Leu Glu Glu Lys His Ser Gln Ile Thr Glu Leu Glu 
            180                 185                 190         


Asn Leu Val Gln Arg Met Glu Lys Glu Lys Arg Thr Leu Leu Glu Arg 
        195                 200                 205             


Lys Leu Ser Leu Glu Asn Lys Leu Leu Gln Leu Lys Ser Ser Ala Thr 
    210                 215                 220                 


Tyr Gly Lys Ser Cys Gln Asp Leu Gln Arg Glu Ile Ser Ile Leu Gln 
225                 230                 235                 240 


Glu Gln Ile Ser His Leu Gln Phe Val Ile His Ser Gln His Gln Asn 
                245                 250                 255     


Leu Arg Ser Val Ile Gln Glu Met Glu Gly Leu Lys Asn Asn Leu Lys 
            260                 265                 270         


Glu Gln Asp Lys Arg Ile Glu Asn Leu Arg Glu Lys Val Asn Ile Leu 
        275                 280                 285             


Glu Ala Gln Asn Lys Glu Leu Lys Thr Gln Val Ala Leu Ser Ser Glu 
    290                 295                 300                 


Thr Pro Arg Thr Lys Val Ser Lys Ala Val Ser Thr Ser Glu Leu Lys 
305                 310                 315                 320 


Thr Glu Gly Val Ser Pro Tyr Leu Met Leu Ile Arg Leu Arg Lys 
                325                 330                 335 


<210>  1699
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC6__Homo_sapiens__NP_005427

<400>  1699

Met Ala Asp Ser Ala Ser Glu Ser Asp Thr Asp Gly Ala Gly Gly Asn 
1               5                   10                  15      


Ser Ser Ser Ser Ala Ala Met Gln Ser Ser Cys Ser Ser Thr Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Ser Gly Gly 
        35                  40                  45              


Ile Val Ile Ser Pro Phe Arg Leu Glu Glu Leu Thr Asn Arg Leu Ala 
    50                  55                  60                  


Ser Leu Gln Gln Glu Asn Lys Val Leu Lys Ile Glu Leu Glu Thr Tyr 
65                  70                  75                  80  


Lys Leu Lys Cys Lys Ala Leu Gln Glu Glu Asn Arg Asp Leu Arg Lys 
                85                  90                  95      


Ala Ser Val Thr Ile Gln Ala Arg Ala Glu Gln Glu Glu Glu Phe Ile 
            100                 105                 110         


Ser Asn Thr Leu Phe Lys Lys Ile Gln Ala Leu Gln Lys Glu Lys Glu 
        115                 120                 125             


Thr Leu Ala Val Asn Tyr Glu Lys Glu Glu Glu Phe Leu Thr Asn Glu 
    130                 135                 140                 


Leu Ser Arg Lys Leu Met Gln Leu Gln His Glu Lys Ala Glu Leu Glu 
145                 150                 155                 160 


Gln His Leu Glu Gln Glu Gln Glu Phe Gln Val Asn Lys Leu Met Lys 
                165                 170                 175     


Lys Ile Lys Lys Leu Glu Asn Asp Thr Ile Ser Lys Gln Leu Thr Leu 
            180                 185                 190         


Glu Gln Leu Arg Arg Glu Lys Ile Asp Leu Glu Asn Thr Leu Glu Gln 
        195                 200                 205             


Glu Gln Glu Ala Leu Val Asn Arg Leu Trp Lys Arg Met Asp Lys Leu 
    210                 215                 220                 


Glu Ala Glu Lys Arg Ile Leu Gln Glu Lys Leu Asp Gln Pro Val Ser 
225                 230                 235                 240 


Ala Pro Pro Ser Pro Arg Asp Ile Ser Met Glu Ile Asp Ser Pro Glu 
                245                 250                 255     


Asn Met Met Arg His Ile Arg Phe Leu Lys Asn Glu Val Glu Arg Leu 
            260                 265                 270         


Lys Lys Gln Leu Arg Ala Ala Gln Leu Gln His Ser Glu Lys Met Ala 
        275                 280                 285             


Gln Tyr Leu Glu Glu Glu Arg His Met Arg Glu Glu Asn Leu Arg Leu 
    290                 295                 300                 


Gln Arg Lys Leu Gln Arg Glu Met Glu Arg Arg Glu Ala Leu Cys Arg 
305                 310                 315                 320 


Gln Leu Ser Glu Ser Glu Ser Ser Leu Glu Met Asp Asp Glu Arg Tyr 
                325                 330                 335     


Phe Asn Glu Met Ser Ala Gln Gly Leu Arg Pro Arg Thr Val Ser Ser 
            340                 345                 350         


Pro Ile Pro Tyr Thr Pro Ser Pro Ser Ser Ser Arg Pro Ile Ser Pro 
        355                 360                 365             


Gly Leu Ser Tyr Ala Ser His Thr Val Gly Phe Thr Pro Pro Thr Ser 
    370                 375                 380                 


Leu Thr Arg Ala Gly Met Ser Tyr Tyr Asn Ser Pro Gly Leu His Val 
385                 390                 395                 400 


Gln His Met Gly Thr Ser His Gly Ile Thr Arg Pro Ser Pro Arg Arg 
                405                 410                 415     


Ser Asn Ser Pro Asp Lys Phe Lys Arg Pro Thr Pro Pro Pro Ser Pro 
            420                 425                 430         


Asn Thr Gln Thr Pro Val Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        435                 440                 445             


Met Gln Pro Thr Val Pro Ser Ala Ala Thr Ser Gln Pro Thr Pro Ser 
    450                 455                 460                 


Gln His Ser Ala His Pro Ser Ser Gln Pro 
465                 470                 


<210>  1700
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC78__Homo_sapiens__NP_001026907

<400>  1700

Met Glu His Ala Ala Thr Thr Gly Pro Arg Pro Gly Pro Pro Ser Arg 
1               5                   10                  15      


Arg Val Glu Asn Val Val Leu Arg Ala Lys Asp Trp Leu Pro Gly Ala 
            20                  25                  30          


Pro Gly Gly Thr Ala Val Trp Ala Thr Ser Leu Glu Ala Glu Val Pro 
        35                  40                  45              


Pro Asp Leu Ala Leu Asn Lys Glu Gln Gln Leu Gln Ile Ser Lys Glu 
    50                  55                  60                  


Leu Val Asp Ile Gln Ile Thr Thr His His Leu His Glu Gln His Glu 
65                  70                  75                  80  


Ala Glu Ile Phe Gln Leu Lys Ser Glu Ile Leu Arg Leu Glu Ser Arg 
                85                  90                  95      


Val Leu Glu Leu Glu Leu Arg Gly Asp Gly Thr Ser Gln Gly Cys Ala 
            100                 105                 110         


Val Pro Val Glu Ser Asp Pro Arg His Pro Arg Ala Ala Ala Gln Glu 
        115                 120                 125             


Leu Arg His Lys Ala Gln Val Pro Gly His Ser Asp Asp His Arg Phe 
    130                 135                 140                 


Gln Val Gln Pro Lys Asn Thr Met Asn Pro Glu Asn Glu Gln His Arg 
145                 150                 155                 160 


Leu Gly Ser Gly Leu Gln Gly Glu Val Lys Trp Ala Leu Glu His Gln 
                165                 170                 175     


Glu Ala Arg Gln Gln Ala Leu Val Thr Arg Val Ala Thr Leu Gly Arg 
            180                 185                 190         


Gln Leu Gln Gly Ala Arg Glu Glu Ala Arg Ala Ala Gly Gln Arg Leu 
        195                 200                 205             


Ala Thr Gln Ala Val Val Leu Cys Ser Cys Gln Gly Gln Leu Arg Gln 
    210                 215                 220                 


Ala Glu Ala Glu Asn Ala Arg Leu Gln Leu Gln Leu Lys Lys Leu Lys 
225                 230                 235                 240 


Asp Glu Tyr Val Leu Arg Leu Gln His Cys Ala Trp Gln Ala Val Glu 
                245                 250                 255     


His Ala Asp Gly Ala Gly Gln Ala Pro Ala Thr Thr Ala Leu Arg Thr 
            260                 265                 270         


Phe Leu Glu Ala Thr Leu Glu Asp Ile Arg Ala Ala His Arg Ser Arg 
        275                 280                 285             


Glu Gln Gln Leu Ala Arg Ala Ala Arg Ser Tyr His Lys Arg Leu Val 
    290                 295                 300                 


Asp Leu Ser Arg Arg His Glu Glu Leu Leu Val Ala Tyr Arg Ala Pro 
305                 310                 315                 320 


Gly Asn Pro Gln Ala Ile Phe Asp Ile Ala Ser Leu Asp Leu Glu Pro 
                325                 330                 335     


Leu Pro Val Pro Leu Val Thr Asp Phe Ser His Arg Glu Asp Gln His 
            340                 345                 350         


Gly Gly Pro Gly Ala Leu Leu Ser Ser Pro Lys Lys Arg Pro Gly Gly 
        355                 360                 365             


Ala Ser Gln Gly Gly Thr Ser Glu Pro Gln Gly Leu Asp Ala Ala Ser 
    370                 375                 380                 


Trp Ala Gln Ile His Gln Lys Leu Arg Asp Phe Ser Arg Ser Thr Gln 
385                 390                 395                 400 


Ser Trp Asn Gly Ser Gly His Ser Cys Trp Ser Gly Pro Arg Trp Leu 
                405                 410                 415     


Lys Ser Asn Phe Leu Ser Tyr Arg Ser Thr Trp Thr Ser Thr Trp Ala 
            420                 425                 430         


Gly Thr Ser Thr Lys Ser 
        435             


<210>  1701
<211>  950
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC80__Homo_sapiens__NP_955805

<400>  1701

Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 
1               5                   10                  15      


Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 
            20                  25                  30          


His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 
        35                  40                  45              


Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 
    50                  55                  60                  


Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 
65                  70                  75                  80  


Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 
                85                  90                  95      


Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 
            100                 105                 110         


Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 
        115                 120                 125             


Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 
    130                 135                 140                 


Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 
145                 150                 155                 160 


Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 
                165                 170                 175     


Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 
            180                 185                 190         


Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 
        195                 200                 205             


Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 
    210                 215                 220                 


Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 
225                 230                 235                 240 


Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 
                245                 250                 255     


Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 
            260                 265                 270         


Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 
        275                 280                 285             


Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 
    290                 295                 300                 


Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 
305                 310                 315                 320 


Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 
                325                 330                 335     


Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 
            340                 345                 350         


Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 
        355                 360                 365             


Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 
    370                 375                 380                 


Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 
                405                 410                 415     


Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 
            420                 425                 430         


Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 
        435                 440                 445             


Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 
    450                 455                 460                 


Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 
465                 470                 475                 480 


Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 
                485                 490                 495     


Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 
            500                 505                 510         


Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 
        515                 520                 525             


Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 
    530                 535                 540                 


Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 
545                 550                 555                 560 


Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 
                565                 570                 575     


Lys Gln Glu Lys Glu Lys Ser Lys Lys Lys Lys Gly Gly Lys Thr Glu 
            580                 585                 590         


Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 
        595                 600                 605             


Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 
    610                 615                 620                 


Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 
625                 630                 635                 640 


Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 
                645                 650                 655     


Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 
            660                 665                 670         


Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 
        675                 680                 685             


Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 
    690                 695                 700                 


Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 
705                 710                 715                 720 


Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 
                725                 730                 735     


Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 
            740                 745                 750         


Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 
        755                 760                 765             


Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 
    770                 775                 780                 


Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 
785                 790                 795                 800 


Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 
                805                 810                 815     


Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 
            820                 825                 830         


Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 
        835                 840                 845             


Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 
    850                 855                 860                 


Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 
865                 870                 875                 880 


Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 
                885                 890                 895     


Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 
            900                 905                 910         


Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 
        915                 920                 925             


Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 
    930                 935                 940                 


His His Gly Tyr Pro Tyr 
945                 950 


<210>  1702
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC83__Homo_sapiens__NP_001273088

<400>  1702

Met Glu Asn Ser Gly Lys Ala Asn Lys Lys Asp Thr His Asp Gly Pro 
1               5                   10                  15      


Pro Lys Glu Ile Lys Leu Pro Thr Ser Glu Ala Leu Leu Asp Tyr Gln 
            20                  25                  30          


Cys Gln Ile Lys Glu Asp Ala Val Glu Gln Phe Met Phe Gln Ile Lys 
        35                  40                  45              


Thr Leu Arg Lys Lys Asn Gln Lys Tyr His Glu Arg Asn Ser Arg Leu 
    50                  55                  60                  


Lys Glu Glu Gln Ile Trp His Ile Arg His Leu Leu Lys Glu Leu Ser 
65                  70                  75                  80  


Glu Glu Lys Ala Glu Gly Leu Pro Val Val Thr Arg Glu Asp Val Glu 
                85                  90                  95      


Glu Ala Met Lys Glu Lys Trp Lys Phe Glu Arg Asp Gln Glu Lys Asn 
            100                 105                 110         


Leu Arg Asp Met Arg Met Gln Ile Ser Asn Ala Glu Lys Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Ser Glu Lys Glu Tyr Trp Glu Glu Tyr Lys Asn Val Gly 
    130                 135                 140                 


Ser Glu Arg His Ala Lys Leu Ile Thr Ser Leu Gln Asn Asp Ile Asn 
145                 150                 155                 160 


Thr Val Lys Glu Asn Ala Glu Lys Met Ser Glu His Tyr Lys Ile Thr 
                165                 170                 175     


Leu Glu Asp Thr Arg Lys Lys Ile Ile Lys Glu Thr Leu Leu Gln Leu 
            180                 185                 190         


Asp Gln Lys Lys Glu Trp Ala Thr Gln Asn Ala Val Lys Leu Ile Asp 
        195                 200                 205             


Lys Gly Ser Tyr Leu Glu Ile Trp Glu Asn Asp Trp Leu Lys Lys Glu 
    210                 215                 220                 


Val Ala Ile His Arg Lys Glu Val Glu Glu Leu Lys Asn Ala Ile His 
225                 230                 235                 240 


Glu Leu Glu Ala Glu Asn Leu Val Leu Ile Asp Gln Leu Ser Asn Cys 
                245                 250                 255     


Arg Leu Val Asp Leu Lys Ile Pro Arg Arg Leu Tyr Leu Thr Gln Ala 
            260                 265                 270         


Ala Gly Leu Glu Val Pro Pro Glu Glu Met Ser Leu Glu Leu Pro Glu 
        275                 280                 285             


Thr His Ile Glu Glu Lys Ser Glu Leu Gln Pro Thr Glu Val Glu Ser 
    290                 295                 300                 


Arg Asp Leu Met Ser Ser Ser Asp Glu Ser Thr Ile Leu His Leu Ser 
305                 310                 315                 320 


His Glu Asn Ser Ile Glu Asp Leu Gln Tyr Val Lys Ile Asp Lys Glu 
                325                 330                 335     


Glu Asn Ser Gly Thr Glu Phe Gly Asp Thr Asp Met Lys Tyr Leu Leu 
            340                 345                 350         


Tyr Glu Asp Glu Lys Asp Phe Lys Asp Tyr Val Asn Leu Gly Pro Leu 
        355                 360                 365             


Gly Val Lys Leu Met Ser Val Glu Ser Lys Lys Met Pro Ile His Phe 
    370                 375                 380                 


Gln Glu Lys Glu Ile Pro Val Lys Leu Tyr Lys Asp Val Arg Ser Pro 
385                 390                 395                 400 


Glu Ser His Ile Thr Tyr Lys Met Met Lys Ser Phe Leu 
                405                 410             


<210>  1703
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC85A__Homo_sapiens__NP_001073902

<400>  1703

Met Ser Lys Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Glu 
1               5                   10                  15      


Ser Cys Ser Pro Ala Pro Ala Gly Ser Ser Ala Ala Pro Pro Ala Pro 
            20                  25                  30          


Val Glu Asp Leu Ser Lys Val Ser Asp Glu Glu Leu Leu Gln Trp Ser 
        35                  40                  45              


Lys Glu Glu Leu Ile Arg Ser Leu Arg Arg Ala Glu Ala Glu Lys Val 
    50                  55                  60                  


Ser Ala Met Leu Asp His Ser Asn Leu Ile Arg Glu Val Asn Arg Arg 
65                  70                  75                  80  


Leu Gln Leu His Leu Gly Glu Ile Arg Gly Leu Lys Asp Ile Asn Gln 
                85                  90                  95      


Lys Leu Gln Glu Asp Asn Gln Glu Leu Arg Asp Leu Cys Cys Phe Leu 
            100                 105                 110         


Asp Asp Asp Arg Gln Lys Gly Lys Arg Val Ser Arg Glu Trp Gln Arg 
        115                 120                 125             


Leu Gly Arg Tyr Thr Ala Gly Val Met His Lys Glu Val Ala Leu Tyr 
    130                 135                 140                 


Leu Gln Lys Leu Lys Asp Leu Glu Val Lys Gln Glu Glu Val Val Lys 
145                 150                 155                 160 


Glu Asn Met Glu Leu Lys Glu Leu Cys Val Leu Leu Asp Glu Glu Lys 
                165                 170                 175     


Gly Ala Gly Cys Ala Gly Ser Arg Cys Ser Ile Asp Ser Gln Ala Ser 
            180                 185                 190         


Leu Cys Gln Leu Thr Ala Ser Thr Ala Pro Tyr Val Arg Asp Val Gly 
        195                 200                 205             


Asp Gly Ser Ser Thr Ser Ser Thr Gly Ser Thr Asp Ser Pro Asp His 
    210                 215                 220                 


His Lys His His Ala Ser Ser Gly Ser Pro Glu His Leu Gln Lys Pro 
225                 230                 235                 240 


Arg Ser Glu Gly Ser Pro Glu His Ser Lys His Arg Ser Ala Ser Pro 
                245                 250                 255     


Glu His Pro Gln Lys Pro Arg Ala Cys Gly Thr Pro Asp Arg Pro Lys 
            260                 265                 270         


Ala Leu Lys Gly Pro Ser Pro Glu His His Lys Pro Leu Cys Lys Gly 
        275                 280                 285             


Ser Pro Glu Gln Gln Arg His Pro His Pro Gly Ser Ser Pro Glu Thr 
    290                 295                 300                 


Leu Pro Lys His Val Leu Ser Gly Ser Pro Glu His Phe Gln Lys His 
305                 310                 315                 320 


Arg Ser Gly Ser Ser Pro Glu His Ala Arg His Ser Gly Gly Ser Pro 
                325                 330                 335     


Glu His Leu Gln Lys His Ala Leu Gly Gly Ser Leu Glu His Leu Pro 
            340                 345                 350         


Arg Ala Arg Gly Thr Ser Pro Glu His Leu Lys Gln His Tyr Gly Gly 
        355                 360                 365             


Ser Pro Asp His Lys His Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Thr Leu Arg Arg Gln Ala Gln Glu Asp 
385                 390                 395                 400 


Gly Ser Pro His His Arg Asn Val Tyr Ser Gly Met Asn Glu Ser Thr 
                405                 410                 415     


Leu Ser Tyr Val Arg Gln Leu Glu Ala Arg Val Arg Gln Leu Glu Glu 
            420                 425                 430         


Glu Asn Arg Met Leu Pro Gln Ala Ser Gln Asn Arg Arg Gln Pro Pro 
        435                 440                 445             


Thr Arg Asn Ser Ser Asn Met Glu Lys Gly Trp Gly Ser Arg Ala Arg 
    450                 455                 460                 


Arg Val Leu Gln Trp Trp Gln Gly Cys Arg Gly Ile Gly Arg Cys Leu 
465                 470                 475                 480 


Pro Thr Leu Pro Gly Ser Phe Arg Leu Ser Ser Gly Ala Asp Gly Ser 
                485                 490                 495     


Asn Ser Ser Pro Asn Ser Ala Ala Ser Phe Ser Gly His Ala Thr Pro 
            500                 505                 510         


Ser Gln Gln Pro Glu Pro Val Val His Ser Leu Lys Val Val Trp Arg 
        515                 520                 525             


Lys Leu Gly Asp Ala Ala Gly Ser Cys Pro Gly Ile Arg Gln His Leu 
    530                 535                 540                 


Ser Gly Asn Gln Tyr Lys Gly Pro Met 
545                 550             


<210>  1704
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC86__Homo_sapiens__NP_077003

<400>  1704

Met Asp Thr Pro Leu Arg Arg Ser Arg Arg Leu Gly Gly Leu Arg Pro 
1               5                   10                  15      


Glu Ser Pro Glu Ser Leu Thr Ser Val Ser Arg Thr Arg Arg Ala Leu 
            20                  25                  30          


Val Glu Phe Glu Ser Asn Pro Glu Glu Thr Arg Glu Pro Gly Ser Pro 
        35                  40                  45              


Pro Ser Val Gln Arg Ala Gly Leu Gly Ser Pro Glu Arg Pro Pro Lys 
    50                  55                  60                  


Thr Ser Pro Gly Ser Pro Arg Leu Gln Gln Gly Ala Gly Leu Glu Ser 
65                  70                  75                  80  


Pro Gln Gly Gln Pro Glu Pro Gly Ala Ala Ser Pro Gln Arg Gln Gln 
                85                  90                  95      


Asp Leu His Leu Glu Ser Pro Gln Arg Gln Pro Glu Tyr Ser Pro Glu 
            100                 105                 110         


Ser Pro Arg Cys Gln Pro Lys Pro Ser Glu Glu Ala Pro Lys Cys Ser 
        115                 120                 125             


Gln Asp Gln Gly Val Leu Ala Ser Glu Leu Ala Gln Asn Lys Glu Glu 
    130                 135                 140                 


Leu Thr Pro Gly Ala Pro Gln His Gln Leu Pro Pro Val Pro Gly Ser 
145                 150                 155                 160 


Pro Glu Pro Tyr Pro Gly Gln Gln Ala Pro Gly Pro Glu Pro Ser Gln 
                165                 170                 175     


Pro Leu Leu Glu Leu Thr Pro Arg Ala Pro Gly Ser Pro Arg Gly Gln 
            180                 185                 190         


His Glu Pro Ser Lys Pro Pro Pro Ala Gly Glu Thr Val Thr Gly Gly 
        195                 200                 205             


Phe Gly Ala Lys Lys Arg Lys Gly Ser Ser Ser Gln Ala Pro Ala Ser 
    210                 215                 220                 


Lys Lys Leu Asn Lys Glu Glu Leu Pro Val Ile Pro Lys Gly Lys Pro 
225                 230                 235                 240 


Lys Ser Gly Arg Val Trp Lys Asp Arg Ser Lys Lys Arg Phe Ser Gln 
                245                 250                 255     


Met Leu Gln Asp Lys Pro Leu Arg Thr Ser Trp Gln Arg Lys Met Lys 
            260                 265                 270         


Glu Arg Gln Glu Arg Lys Leu Ala Lys Asp Phe Ala Arg His Leu Glu 
        275                 280                 285             


Glu Glu Lys Glu Arg Arg Arg Gln Glu Lys Lys Gln Arg Arg Ala Glu 
    290                 295                 300                 


Asn Leu Lys Arg Arg Leu Glu Asn Glu Arg Lys Ala Glu Val Val Gln 
305                 310                 315                 320 


Val Ile Arg Asn Pro Ala Lys Leu Lys Arg Ala Lys Lys Lys Gln Leu 
                325                 330                 335     


Arg Ser Ile Glu Lys Arg Asp Thr Leu Ala Leu Leu Gln Lys Gln Pro 
            340                 345                 350         


Pro Gln Gln Pro Ala Ala Lys Ile 
        355                 360 


<210>  1705
<211>  1870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC88A__Homo_sapiens__NP_001129069

<400>  1705

Met Glu Asn Glu Ile Phe Thr Pro Leu Leu Glu Gln Phe Met Thr Ser 
1               5                   10                  15      


Pro Leu Val Thr Trp Val Lys Thr Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Thr Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Thr Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Thr Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Thr Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Thr Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Thr Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Thr Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Thr Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Thr Lys Thr Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Thr Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Thr Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Thr Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Thr Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Thr Lys Thr Val Glu Glu Leu Arg 
465                 470                 475                 480 


Thr Thr Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Thr Ile Glu Thr 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Thr Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Thr Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Thr Asn Leu Lys Ile Thr Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Thr Leu Asp Ser Phe Lys Asn Leu Thr Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Thr Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Thr Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Thr Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Thr Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Thr Thr Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Thr Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Thr Ile Asp Ile Lys Thr Leu Val Thr Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Thr Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Thr His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Thr Asp Asp Arg Tyr Lys Leu Leu Glu Ser Lys Leu 
945                 950                 955                 960 


Glu Ser Thr Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile Ala 
                965                 970                 975     


Ala Leu Glu Ala Arg Leu Glu Glu Ser Thr Asn Tyr Asn Gln Gln Leu 
            980                 985                 990         


Arg Gln Glu Leu Lys Thr Val Lys  Lys Asn Tyr Glu Ala  Leu Lys Gln 
        995                 1000                 1005             


Arg Gln  Asp Glu Glu Arg Met  Val Gln Ser Ser Pro  Pro Ile Ser 
    1010                 1015                 1020             


Gly Glu  Asp Asn Lys Trp Glu  Arg Glu Ser Gln Glu  Thr Thr Arg 
    1025                 1030                 1035             


Glu Leu  Leu Lys Val Lys Asp  Arg Leu Ile Glu Val  Glu Arg Asn 
    1040                 1045                 1050             


Asn Ala  Thr Leu Gln Ala Glu  Lys Gln Ala Leu Lys  Thr Gln Leu 
    1055                 1060                 1065             


Lys Gln  Leu Glu Thr Gln Asn  Asn Asn Leu Gln Ala  Gln Ile Leu 
    1070                 1075                 1080             


Ala Leu  Gln Arg Gln Thr Val  Ser Leu Gln Glu Gln  Asn Thr Thr 
    1085                 1090                 1095             


Leu Gln  Thr Gln Asn Ala Lys  Leu Gln Val Glu Asn  Ser Thr Leu 
    1100                 1105                 1110             


Asn Ser  Gln Ser Thr Ser Leu  Met Asn Gln Asn Ala  Gln Leu Leu 
    1115                 1120                 1125             


Ile Gln  Gln Ser Ser Leu Glu  Asn Glu Asn Glu Ser  Val Ile Lys 
    1130                 1135                 1140             


Glu Arg  Glu Asp Leu Lys Ser  Leu Tyr Asp Ser Leu  Ile Lys Asp 
    1145                 1150                 1155             


His Glu  Lys Leu Glu Leu Leu  His Glu Arg Gln Ala  Ser Glu Tyr 
    1160                 1165                 1170             


Glu Ser  Leu Ile Ser Lys His  Gly Thr Leu Lys Ser  Ala His Lys 
    1175                 1180                 1185             


Asn Leu  Glu Val Glu His Arg  Asp Leu Glu Asp Arg  Tyr Asn Gln 
    1190                 1195                 1200             


Leu Leu  Lys Gln Lys Gly Gln  Leu Glu Asp Leu Glu  Lys Met Leu 
    1205                 1210                 1215             


Lys Val  Glu Gln Glu Lys Met  Leu Leu Glu Asn Lys  Asn His Glu 
    1220                 1225                 1230             


Thr Val  Ala Ala Glu Tyr Lys  Lys Leu Cys Gly Glu  Asn Asp Arg 
    1235                 1240                 1245             


Leu Asn  His Thr Tyr Ser Gln  Leu Leu Lys Glu Thr  Glu Val Leu 
    1250                 1255                 1260             


Gln Thr  Asp His Lys Asn Leu  Lys Ser Leu Leu Asn  Asn Ser Lys 
    1265                 1270                 1275             


Leu Glu  Gln Thr Arg Leu Glu  Ala Glu Phe Ser Lys  Leu Lys Glu 
    1280                 1285                 1290             


Gln Tyr  Gln Gln Leu Asp Ile  Thr Ser Thr Lys Leu  Asn Asn Gln 
    1295                 1300                 1305             


Cys Glu  Leu Leu Ser Gln Leu  Lys Gly Asn Leu Glu  Glu Glu Asn 
    1310                 1315                 1320             


Arg His  Leu Leu Asp Gln Ile  Gln Thr Leu Met Leu  Gln Asn Arg 
    1325                 1330                 1335             


Thr Leu  Leu Glu Gln Asn Met  Glu Ser Lys Asp Leu  Phe His Val 
    1340                 1345                 1350             


Glu Gln  Arg Gln Tyr Ile Asp  Lys Leu Asn Glu Leu  Arg Arg Gln 
    1355                 1360                 1365             


Lys Glu  Lys Leu Glu Glu Lys  Ile Met Asp Gln Tyr  Lys Phe Tyr 
    1370                 1375                 1380             


Asp Pro  Ser Pro Pro Arg Arg  Arg Gly Asn Trp Ile  Thr Leu Lys 
    1385                 1390                 1395             


Met Arg  Lys Leu Ile Lys Ser  Lys Lys Asp Ile Asn  Arg Glu Arg 
    1400                 1405                 1410             


Gln Lys  Ser Leu Thr Leu Thr  Pro Thr Arg Ser Asp  Ser Ser Glu 
    1415                 1420                 1425             


Gly Phe  Leu Gln Leu Pro His  Gln Asp Ser Gln Asp  Ser Ser Ser 
    1430                 1435                 1440             


Val Gly  Ser Asn Ser Leu Glu  Asp Gly Gln Thr Leu  Gly Thr Lys 
    1445                 1450                 1455             


Lys Ser  Ser Met Val Ala Leu  Lys Arg Leu Pro Phe  Leu Arg Asn 
    1460                 1465                 1470             


Arg Pro  Lys Asp Lys Asp Lys  Met Lys Ala Cys Tyr  Arg Arg Ser 
    1475                 1480                 1485             


Met Ser  Met Asn Asp Leu Val  Gln Ser Met Val Leu  Ala Gly Gln 
    1490                 1495                 1500             


Trp Thr  Gly Ser Thr Glu Asn  Leu Glu Val Pro Asp  Asp Ile Ser 
    1505                 1510                 1515             


Thr Gly  Lys Arg Arg Lys Glu  Leu Gly Ala Met Ala  Phe Ser Thr 
    1520                 1525                 1530             


Thr Ala  Ile Asn Phe Ser Thr  Val Asn Ser Ser Ala  Gly Phe Arg 
    1535                 1540                 1545             


Ser Lys  Gln Leu Val Asn Asn  Lys Asp Thr Thr Ser  Phe Glu Asp 
    1550                 1555                 1560             


Ile Ser  Pro Gln Gly Val Ser  Asp Asp Ser Ser Thr  Gly Ser Arg 
    1565                 1570                 1575             


Val His  Ala Ser Arg Pro Ala  Ser Leu Asp Ser Gly  Arg Thr Ser 
    1580                 1585                 1590             


Thr Ser  Asn Ser Asn Asn Asn  Ala Ser Leu His Glu  Val Lys Ala 
    1595                 1600                 1605             


Gly Ala  Val Asn Asn Gln Ser  Arg Pro Gln Ser His  Ser Ser Gly 
    1610                 1615                 1620             


Glu Phe  Ser Leu Leu His Asp  His Glu Ala Trp Ser  Ser Ser Gly 
    1625                 1630                 1635             


Ser Ser  Pro Ile Gln Tyr Leu  Lys Arg Gln Thr Arg  Ser Ser Pro 
    1640                 1645                 1650             


Val Leu  Gln His Lys Ile Ser  Glu Thr Leu Glu Ser  Arg His His 
    1655                 1660                 1665             


Lys Ile  Lys Thr Gly Ser Pro  Gly Ser Glu Val Val  Thr Leu Gln 
    1670                 1675                 1680             


Gln Phe  Leu Glu Glu Ser Asn  Lys Leu Thr Ser Val  Gln Ile Lys 
    1685                 1690                 1695             


Ser Ser  Ser Gln Glu Asn Leu  Leu Asp Glu Val Met  Lys Ser Leu 
    1700                 1705                 1710             


Ser Val  Ser Ser Asp Phe Leu  Gly Lys Asp Lys Pro  Val Ser Cys 
    1715                 1720                 1725             


Gly Leu  Ala Arg Ser Val Ser  Gly Lys Thr Pro Gly  Asp Phe Tyr 
    1730                 1735                 1740             


Asp Arg  Arg Thr Thr Lys Pro  Glu Phe Leu Arg Pro  Gly Pro Arg 
    1745                 1750                 1755             


Lys Thr  Glu Asp Thr Tyr Phe  Ile Ser Ser Ala Gly  Lys Pro Thr 
    1760                 1765                 1770             


Pro Gly  Thr Gln Gly Lys Ile  Lys Leu Val Lys Glu  Ser Ser Leu 
    1775                 1780                 1785             


Ser Arg  Gln Ser Lys Asp Ser  Asn Pro Tyr Ala Thr  Leu Pro Arg 
    1790                 1795                 1800             


Ala Ser  Ser Val Ile Ser Thr  Ala Glu Gly Thr Thr  Arg Arg Thr 
    1805                 1810                 1815             


Ser Ile  His Asp Phe Leu Thr  Lys Asp Ser Arg Leu  Pro Ile Ser 
    1820                 1825                 1830             


Val Asp  Ser Pro Pro Ala Ala  Ala Asp Ser Asn Thr  Thr Ala Ala 
    1835                 1840                 1845             


Ser Asn  Val Asp Lys Val Gln  Glu Ser Arg Asn Ser  Lys Ser Arg 
    1850                 1855                 1860             


Ser Arg  Glu Gln Gln Ser Ser  
    1865                 1870 


<210>  1706
<211>  2028
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC88C__Homo_sapiens__NP_001073883

<400>  1706

Met Asp Val Thr Val Ser Glu Leu Leu Glu Leu Phe Leu Gln Ser Pro 
1               5                   10                  15      


Leu Val Thr Trp Val Lys Thr Phe Gly Pro Phe Gly Ser Gly Ser Gln 
            20                  25                  30          


Asp Asn Leu Thr Met Tyr Met Asp Leu Val Asp Gly Ile Phe Leu Asn 
        35                  40                  45              


Gln Ile Met Leu Gln Ile Asp Pro Arg Pro Thr Asn Gln Arg Ile Asn 
    50                  55                  60                  


Lys His Val Asn Asn Asp Val Asn Leu Arg Ile Gln Asn Leu Thr Ile 
65                  70                  75                  80  


Leu Val Arg Asn Ile Lys Thr Tyr Tyr Gln Glu Val Leu Gln Gln Leu 
                85                  90                  95      


Ile Val Met Asn Leu Pro Asn Val Leu Met Ile Gly Arg Asp Pro Leu 
            100                 105                 110         


Ser Gly Lys Ser Met Glu Glu Ile Lys Lys Val Leu Leu Leu Val Leu 
        115                 120                 125             


Gly Cys Ala Val Gln Cys Glu Arg Lys Glu Glu Phe Ile Glu Arg Ile 
    130                 135                 140                 


Lys Gln Leu Asp Ile Glu Thr Gln Ala Gly Ile Val Ala His Ile Gln 
145                 150                 155                 160 


Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Leu Glu 
                165                 170                 175     


Leu Pro Asp Val Ala Pro Glu Glu Leu Glu Ala Leu Ser Arg Ser Met 
            180                 185                 190         


Val Leu His Leu Arg Arg Leu Ile Asp Gln Arg Asp Glu Cys Thr Glu 
        195                 200                 205             


Leu Ile Val Asp Leu Thr Gln Glu Arg Asp Tyr Leu Gln Ala Gln His 
    210                 215                 220                 


Pro Pro Ser Pro Ile Lys Ser Ser Ser Ala Asp Ser Thr Pro Ser Pro 
225                 230                 235                 240 


Thr Ser Ser Leu Ser Ser Glu Asp Lys Gln His Leu Ala Val Glu Leu 
                245                 250                 255     


Ala Asp Thr Lys Ala Arg Leu Arg Arg Val Arg Gln Glu Leu Glu Asp 
            260                 265                 270         


Lys Thr Glu Gln Leu Val Asp Thr Arg His Glu Val Asp Gln Leu Val 
        275                 280                 285             


Leu Glu Leu Gln Lys Val Lys Gln Glu Asn Ile Gln Leu Ala Ala Asp 
    290                 295                 300                 


Ala Arg Ser Ala Arg Ala Tyr Arg Asp Glu Leu Asp Ser Leu Arg Glu 
305                 310                 315                 320 


Lys Ala Asn Arg Val Glu Arg Leu Glu Leu Glu Leu Thr Arg Cys Lys 
                325                 330                 335     


Glu Lys Leu His Asp Val Asp Phe Tyr Lys Ala Arg Met Glu Glu Leu 
            340                 345                 350         


Arg Glu Asp Asn Ile Ile Leu Ile Glu Thr Lys Ala Met Leu Glu Glu 
        355                 360                 365             


Gln Leu Thr Ala Ala Arg Ala Arg Gly Asp Lys Val His Glu Leu Glu 
    370                 375                 380                 


Lys Glu Asn Leu Gln Leu Lys Ser Lys Leu His Asp Leu Glu Leu Asp 
385                 390                 395                 400 


Arg Asp Thr Asp Lys Lys Arg Ile Glu Glu Leu Leu Glu Glu Asn Met 
                405                 410                 415     


Val Leu Glu Ile Ala Gln Lys Gln Ser Met Asn Glu Ser Ala His Leu 
            420                 425                 430         


Gly Trp Glu Leu Glu Gln Leu Ser Lys Asn Ala Asp Leu Ser Asp Ala 
        435                 440                 445             


Ser Arg Lys Ser Phe Val Phe Glu Leu Asn Glu Cys Ala Ser Ser Arg 
    450                 455                 460                 


Ile Leu Lys Leu Glu Lys Glu Asn Gln Ser Leu Gln Ser Thr Ile Gln 
465                 470                 475                 480 


Gly Leu Arg Asp Ala Ser Leu Val Leu Glu Glu Ser Gly Leu Lys Cys 
                485                 490                 495     


Gly Glu Leu Glu Lys Glu Asn His Gln Leu Ser Lys Lys Ile Glu Lys 
            500                 505                 510         


Leu Gln Thr Gln Leu Glu Arg Glu Lys Gln Ser Asn Gln Asp Leu Glu 
        515                 520                 525             


Thr Leu Ser Glu Glu Leu Ile Arg Glu Lys Glu Gln Leu Gln Ser Asp 
    530                 535                 540                 


Met Glu Thr Leu Lys Ala Asp Lys Ala Arg Gln Ile Lys Asp Leu Glu 
545                 550                 555                 560 


Gln Glu Lys Asp His Leu Asn Arg Ala Met Trp Ser Leu Arg Glu Arg 
                565                 570                 575     


Ser Gln Val Ser Ser Glu Ala Arg Met Lys Asp Val Glu Lys Glu Asn 
            580                 585                 590         


Lys Ala Leu His Gln Thr Val Thr Glu Ala Asn Gly Lys Leu Ser Gln 
        595                 600                 605             


Leu Glu Phe Glu Lys Arg Gln Leu His Arg Asp Leu Glu Gln Ala Lys 
    610                 615                 620                 


Glu Lys Gly Glu Arg Ala Glu Lys Leu Glu Arg Glu Leu Gln Arg Leu 
625                 630                 635                 640 


Gln Glu Glu Asn Gly Arg Leu Ala Arg Lys Val Thr Ser Leu Glu Thr 
                645                 650                 655     


Ala Thr Glu Lys Val Glu Ala Leu Glu His Glu Ser Gln Gly Leu Gln 
            660                 665                 670         


Leu Glu Asn Arg Thr Leu Arg Lys Ser Leu Asp Thr Leu Gln Asn Val 
        675                 680                 685             


Ser Leu Gln Leu Glu Gly Leu Glu Arg Asp Asn Lys Gln Leu Asp Ala 
    690                 695                 700                 


Glu Asn Leu Glu Leu Arg Arg Leu Val Glu Thr Met Arg Phe Thr Ser 
705                 710                 715                 720 


Thr Lys Leu Ala Gln Met Glu Arg Glu Asn Gln Gln Leu Glu Arg Glu 
                725                 730                 735     


Lys Glu Glu Leu Arg Lys Asn Val Asp Leu Leu Lys Ala Leu Gly Lys 
            740                 745                 750         


Lys Ser Glu Arg Leu Glu Leu Ser Tyr Gln Ser Val Ser Ala Glu Asn 
        755                 760                 765             


Leu Arg Leu Gln Gln Ser Leu Glu Ser Ser Ser His Lys Thr Gln Thr 
    770                 775                 780                 


Leu Glu Ser Glu Leu Gly Glu Leu Glu Ala Glu Arg Gln Ala Leu Arg 
785                 790                 795                 800 


Arg Asp Leu Glu Ala Leu Arg Leu Ala Asn Ala Gln Leu Glu Gly Ala 
                805                 810                 815     


Glu Lys Asp Arg Lys Ala Leu Glu Gln Glu Val Ala Gln Leu Glu Lys 
            820                 825                 830         


Asp Lys Lys Leu Leu Glu Lys Glu Ala Lys Arg Leu Trp Gln Gln Val 
        835                 840                 845             


Glu Leu Lys Asp Ala Val Leu Asp Asp Ser Thr Ala Lys Leu Ser Ala 
    850                 855                 860                 


Val Glu Lys Glu Ser Arg Ala Leu Asp Lys Glu Leu Ala Arg Cys Arg 
865                 870                 875                 880 


Asp Ala Ala Gly Lys Leu Lys Glu Leu Glu Lys Asp Asn Arg Asp Leu 
                885                 890                 895     


Thr Lys Gln Val Thr Val His Ala Arg Thr Leu Thr Thr Leu Arg Glu 
            900                 905                 910         


Asp Leu Val Leu Glu Lys Leu Lys Ser Gln Gln Leu Ser Ser Glu Leu 
        915                 920                 925             


Asp Lys Leu Ser Gln Glu Leu Glu Lys Val Gly Leu Asn Arg Glu Leu 
    930                 935                 940                 


Leu Leu Gln Glu Asp Asp Ser Gly Ser Asp Thr Lys Tyr Lys Ile Leu 
945                 950                 955                 960 


Glu Gly Arg Asn Glu Ser Ala Leu Lys Thr Thr Leu Ala Met Lys Glu 
                965                 970                 975     


Glu Lys Ile Val Leu Leu Glu Ala Gln Met Glu Glu Lys Ala Ser Leu 
            980                 985                 990         


Asn Arg Gln Leu Glu Ser Glu Leu  Gln Met Leu Lys Lys  Glu Cys Glu 
        995                 1000                 1005             


Thr Leu  Arg Gln Asn Gln Gly  Glu Gly Gln His Leu  Gln Asn Ser 
    1010                 1015                 1020             


Phe Lys  His Pro Ala Gly Lys  Thr Ala Ala Ser His  Gln Gly Lys 
    1025                 1030                 1035             


Glu Ala  Trp Gly Pro Gly His  Lys Glu Ala Thr Met  Glu Leu Leu 
    1040                 1045                 1050             


Arg Val  Lys Asp Arg Ala Ile  Glu Leu Glu Arg Asn  Asn Ala Ala 
    1055                 1060                 1065             


Leu Gln  Ala Glu Lys Gln Leu  Leu Lys Glu Gln Leu  Gln His Leu 
    1070                 1075                 1080             


Glu Thr  Gln Asn Val Thr Phe  Ser Ser Gln Ile Leu  Thr Leu Gln 
    1085                 1090                 1095             


Lys Gln  Ser Ala Phe Leu Gln  Glu His Asn Thr Thr  Leu Gln Thr 
    1100                 1105                 1110             


Gln Thr  Ala Lys Leu Gln Val  Glu Asn Ser Thr Leu  Ser Ser Gln 
    1115                 1120                 1125             


Ser Ala  Ala Leu Thr Ala Gln  Tyr Thr Leu Leu Gln  Asn His His 
    1130                 1135                 1140             


Thr Ala  Lys Glu Thr Glu Asn  Glu Ser Leu Gln Arg  Gln Gln Glu 
    1145                 1150                 1155             


Gln Leu  Thr Ala Ala Tyr Glu  Ala Leu Leu Gln Asp  His Glu His 
    1160                 1165                 1170             


Leu Gly  Thr Leu His Glu Arg  Gln Ser Ala Glu Tyr  Glu Ala Leu 
    1175                 1180                 1185             


Ile Arg  Gln His Ser Cys Leu  Lys Thr Leu His Arg  Asn Leu Glu 
    1190                 1195                 1200             


Leu Glu  His Lys Glu Leu Gly  Glu Arg His Gly Asp  Met Leu Lys 
    1205                 1210                 1215             


Arg Lys  Ala Glu Leu Glu Glu  Arg Glu Lys Val Leu  Thr Thr Glu 
    1220                 1225                 1230             


Arg Glu  Ala Leu Gln Gln Glu  Gln Arg Thr Asn Ala  Leu Ala Met 
    1235                 1240                 1245             


Gly Glu  Asn Gln Arg Leu Arg  Gly Glu Leu Asp Arg  Val Asn Phe 
    1250                 1255                 1260             


Leu His  His Gln Leu Lys Gly  Glu Tyr Glu Glu Leu  His Ala His 
    1265                 1270                 1275             


Thr Lys  Glu Leu Lys Thr Ser  Leu Asn Asn Ala Gln  Leu Glu Leu 
    1280                 1285                 1290             


Asn Arg  Trp Gln Ala Arg Phe  Asp Glu Leu Lys Glu  Gln His Gln 
    1295                 1300                 1305             


Thr Met  Asp Ile Ser Leu Thr  Lys Leu Asp Asn His  Cys Glu Leu 
    1310                 1315                 1320             


Leu Ser  Arg Leu Lys Gly Asn  Leu Glu Glu Glu Asn  His His Leu 
    1325                 1330                 1335             


Leu Ser  Gln Ile Gln Leu Leu  Ser Gln Gln Asn Gln  Met Leu Leu 
    1340                 1345                 1350             


Glu Gln  Asn Met Glu Asn Lys  Glu Gln Tyr His Glu  Glu Gln Lys 
    1355                 1360                 1365             


Gln Tyr  Ile Asp Lys Leu Asn  Ala Leu Arg Arg His  Lys Glu Lys 
    1370                 1375                 1380             


Leu Glu  Glu Lys Ile Met Asp  Gln Tyr Lys Phe Tyr  Asp Pro Pro 
    1385                 1390                 1395             


Pro Lys  Lys Lys Asn His Trp  Ile Gly Ala Lys Ala  Leu Val Lys 
    1400                 1405                 1410             


Leu Ile  Lys Pro Lys Lys Glu  Gly Ser Arg Glu Arg  Leu Lys Ser 
    1415                 1420                 1425             


Thr Val  Asp Ser Pro Pro Trp  Gln Leu Glu Ser Ser  Asp Pro Ala 
    1430                 1435                 1440             


Ser Pro  Ala Ala Ser Gln Pro  Leu Arg Ser Gln Ala  Glu Asn Pro 
    1445                 1450                 1455             


Asp Thr  Pro Ala Leu Gly Ser  Asn Cys Ala Glu Glu  Arg Asp Ala 
    1460                 1465                 1470             


His Asn  Gly Ser Val Gly Lys  Gly Pro Gly Asp Leu  Lys Pro Lys 
    1475                 1480                 1485             


Arg Gly  Ser Pro His Arg Gly  Ser Leu Asp Arg Thr  Asp Ala Ser 
    1490                 1495                 1500             


Thr Asp  Leu Ala Met Arg Ser  Trp Pro Ser Glu Leu  Gly Ser Arg 
    1505                 1510                 1515             


Thr Cys  Ser Thr Ser Ala Thr  Thr Thr Ala Pro Ser  Asn Ser Thr 
    1520                 1525                 1530             


Pro Ile  Ala Arg His Pro Gly  Arg Thr Lys Gly Tyr  Asn Ser Asp 
    1535                 1540                 1545             


Asp Asn  Leu Cys Glu Pro Ser  Leu Glu Phe Glu Val  Pro Asn His 
    1550                 1555                 1560             


Arg Gln  Tyr Val Ser Arg Pro  Ser Ser Leu Glu Ser  Ser Arg Asn 
    1565                 1570                 1575             


Thr Ser  Ser Asn Ser Ser Pro  Leu Asn Leu Lys Gly  Ser Ser Glu 
    1580                 1585                 1590             


Gln Leu  His Gly Arg Ser Glu  Ser Phe Ser Ser Glu  Asp Leu Ile 
    1595                 1600                 1605             


Pro Ser  Arg Asp Leu Ala Thr  Leu Pro Arg Glu Ala  Ser Thr Pro 
    1610                 1615                 1620             


Gly Arg  Asn Ala Leu Gly Arg  His Glu Tyr Pro Leu  Pro Arg Asn 
    1625                 1630                 1635             


Gly Pro  Leu Pro Gln Glu Gly  Ala Gln Lys Arg Gly  Thr Ala Pro 
    1640                 1645                 1650             


Pro Tyr  Val Gly Val Arg Pro  Cys Ser Ala Ser Pro  Ser Ser Glu 
    1655                 1660                 1665             


Met Val  Thr Leu Glu Glu Phe  Leu Glu Glu Ser Asn  Arg Ser Ser 
    1670                 1675                 1680             


Pro Thr  His Asp Thr Pro Ser  Cys Arg Asp Asp Leu  Leu Ser Asp 
    1685                 1690                 1695             


Tyr Phe  Arg Lys Ala Ser Asp  Pro Pro Ala Ile Gly  Gly Gln Pro 
    1700                 1705                 1710             


Gly Pro  Pro Ala Lys Lys Glu  Gly Ala Lys Met Pro  Thr Asn Phe 
    1715                 1720                 1725             


Val Ala  Pro Thr Val Lys Met  Ala Ala Pro Thr Ser  Glu Gly Arg 
    1730                 1735                 1740             


Pro Leu  Lys Pro Gly Gln Tyr  Val Lys Pro Asn Phe  Arg Leu Thr 
    1745                 1750                 1755             


Glu Ala  Glu Ala Pro Pro Ser  Val Ala Pro Arg Gln  Ala Gln Pro 
    1760                 1765                 1770             


Pro Gln  Ser Leu Ser Leu Gly  Arg Pro Arg Gln Ala  Pro Val Pro 
    1775                 1780                 1785             


Pro Ala  Ser His Ala Pro Ala  Ser Arg Ser Ala Ser  Leu Ser Arg 
    1790                 1795                 1800             


Ala Phe  Ser Leu Ala Ser Ala  Asp Leu Leu Arg Ala  Ser Gly Pro 
    1805                 1810                 1815             


Glu Ala  Cys Lys Gln Glu Ser  Pro Gln Lys Leu Gly  Ala Pro Glu 
    1820                 1825                 1830             


Ala Leu  Gly Gly Arg Glu Thr  Gly Ser His Thr Leu  Gln Ser Pro 
    1835                 1840                 1845             


Ala Pro  Pro Ser Ser His Ser  Leu Ala Arg Glu Arg  Thr Pro Leu 
    1850                 1855                 1860             


Val Gly  Lys Ala Gly Ser Ser  Cys Gln Gly Pro Gly  Pro Arg Ser 
    1865                 1870                 1875             


Arg Pro  Leu Asp Thr Arg Arg  Phe Ser Leu Ala Pro  Pro Lys Glu 
    1880                 1885                 1890             


Glu Arg  Leu Ala Pro Leu His  Gln Ser Ala Thr Ala  Pro Ala Ile 
    1895                 1900                 1905             


Ala Thr  Ala Gly Ala Gly Ala  Ala Ala Ala Gly Ser  Gly Ser Asn 
    1910                 1915                 1920             


Ser Gln  Leu Leu His Phe Ser  Pro Ala Ala Ala Pro  Ala Ala Arg 
    1925                 1930                 1935             


Thr Lys  Pro Lys Ala Pro Pro  Arg Ser Gly Glu Val  Ala Thr Ile 
    1940                 1945                 1950             


Thr Pro  Val Arg Ala Gly Leu  Ser Leu Ser Glu Gly  Asp Gly Val 
    1955                 1960                 1965             


Pro Gly  Gln Gly Cys Ser Glu  Gly Leu Pro Ala Lys  Ser Pro Gly 
    1970                 1975                 1980             


Arg Ser  Pro Asp Leu Ala Pro  His Leu Gly Arg Ala  Leu Glu Asp 
    1985                 1990                 1995             


Cys Ser  Arg Gly Ser Val Ser  Lys Ser Ser Pro Ala  Ser Pro Glu 
    2000                 2005                 2010             


Pro Gly  Gly Asp Pro Gln Thr  Val Trp Tyr Glu Tyr  Gly Cys Val 
    2015                 2020                 2025             


<210>  1707
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC8__Homo_sapiens__NP_114429

<400>  1707

Met Leu Gln Ile Gly Glu Asp Val Asp Tyr Leu Leu Ile Pro Arg Glu 
1               5                   10                  15      


Val Arg Leu Ala Gly Gly Val Trp Arg Val Ile Ser Lys Pro Ala Thr 
            20                  25                  30          


Lys Glu Ala Glu Phe Arg Glu Arg Leu Thr Gln Phe Leu Glu Glu Glu 
        35                  40                  45              


Gly Arg Thr Leu Glu Asp Val Ala Arg Ile Met Glu Lys Ser Thr Pro 
    50                  55                  60                  


His Pro Pro Gln Pro Pro Lys Lys Pro Lys Glu Pro Arg Val Arg Arg 
65                  70                  75                  80  


Arg Val Gln Gln Met Val Thr Pro Pro Pro Arg Leu Val Val Gly Thr 
                85                  90                  95      


Tyr Asp Ser Ser Asn Ala Ser Asp Ser Glu Phe Ser Asp Phe Glu Thr 
            100                 105                 110         


Ser Arg Asp Lys Ser Arg Gln Gly Pro Arg Arg Gly Lys Lys Val Arg 
        115                 120                 125             


Lys Met Pro Val Ser Tyr Leu Gly Ser Lys Phe Leu Gly Ser Asp Leu 
    130                 135                 140                 


Glu Ser Glu Asp Asp Glu Glu Leu Val Glu Ala Phe Leu Arg Arg Gln 
145                 150                 155                 160 


Glu Lys Gln Pro Ser Ala Pro Pro Ala Arg Arg Arg Val Asn Leu Pro 
                165                 170                 175     


Val Pro Met Phe Glu Asp Asn Leu Gly Pro Gln Leu Ser Lys Ala Asp 
            180                 185                 190         


Arg Trp Arg Glu Tyr Val Ser Gln Val Ser Trp Gly Lys Leu Lys Arg 
        195                 200                 205             


Arg Val Lys Gly Trp Ala Pro Arg Ala Gly Pro Gly Val Gly Glu Ala 
    210                 215                 220                 


Arg Leu Ala Ser Thr Ala Val Glu Ser Ala Gly Val Ser Ser Ala Pro 
225                 230                 235                 240 


Glu Gly Thr Ser Pro Gly Asp Arg Leu Gly Asn Ala Gly Asp Val Cys 
                245                 250                 255     


Val Pro Gln Ala Ser Pro Arg Arg Trp Arg Pro Lys Ile Asn Trp Ala 
            260                 265                 270         


Ser Phe Arg Arg Arg Arg Lys Glu Gln Thr Ala Pro Thr Gly Gln Gly 
        275                 280                 285             


Ala Asp Ile Glu Ala Asp Gln Gly Gly Glu Ala Ala Asp Ser Gln Arg 
    290                 295                 300                 


Glu Glu Ala Ile Ala Asp Gln Arg Glu Gly Ala Ala Gly Asn Gln Arg 
305                 310                 315                 320 


Ala Gly Ala Pro Ala Asp Gln Gly Ala Glu Ala Ala Asp Asn Gln Arg 
                325                 330                 335     


Glu Glu Ala Ala Asp Asn Gln Arg Ala Gly Ala Pro Ala Glu Glu Gly 
            340                 345                 350         


Ala Glu Ala Ala Asp Asn Gln Arg Glu Glu Ala Ala Asp Asn Gln Arg 
        355                 360                 365             


Ala Glu Ala Pro Ala Asp Gln Arg Ser Gln Gly Thr Asp Asn His Arg 
    370                 375                 380                 


Glu Glu Ala Ala Asp Asn Gln Arg Ala Glu Ala Pro Ala Asp Gln Gly 
385                 390                 395                 400 


Ser Glu Val Thr Asp Asn Gln Arg Glu Glu Ala Val His Asp Gln Arg 
                405                 410                 415     


Glu Arg Ala Pro Ala Val Gln Gly Ala Asp Asn Gln Arg Ala Gln Ala 
            420                 425                 430         


Arg Ala Gly Gln Arg Ala Glu Ala Ala His Asn Gln Arg Ala Gly Ala 
        435                 440                 445             


Pro Gly Ile Gln Glu Ala Glu Val Ser Ala Ala Gln Gly Thr Thr Gly 
    450                 455                 460                 


Thr Ala Pro Gly Ala Arg Ala Arg Lys Gln Val Lys Thr Val Arg Phe 
465                 470                 475                 480 


Gln Thr Pro Gly Arg Phe Ser Trp Phe Cys Lys Arg Arg Arg Ala Phe 
                485                 490                 495     


Trp His Thr Pro Arg Leu Pro Thr Leu Pro Lys Arg Val Pro Arg Ala 
            500                 505                 510         


Gly Glu Ala Arg Asn Leu Arg Val Leu Arg Ala Glu Ala Arg Ala Glu 
        515                 520                 525             


Ala Glu Gln Gly Glu Gln Glu Asp Gln Leu 
    530                 535             


<210>  1708
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC91__Homo_sapiens__NP_060788

<400>  1708

Met Asp Asp Asp Asp Phe Gly Gly Phe Glu Ala Ala Glu Thr Phe Asp 
1               5                   10                  15      


Gly Gly Ser Gly Glu Thr Gln Thr Thr Ser Pro Ala Ile Pro Trp Ala 
            20                  25                  30          


Ala Phe Pro Ala Val Ser Gly Val His Leu Ser Pro Ser Ser Pro Glu 
        35                  40                  45              


Ile Val Leu Asp Arg Asp His Ser Ser Ser Ile Gly Cys Leu Ser Ser 
    50                  55                  60                  


Asp Ala Ile Ile Ser Ser Pro Glu Asn Thr His Ala Ala Asn Ser Ile 
65                  70                  75                  80  


Val Ser Gln Thr Ile Pro Lys Ala Gln Ile Gln Gln Ser Thr His Thr 
                85                  90                  95      


His Leu Asp Ile Ser Leu Phe Pro Leu Gly Leu Thr Asp Glu Lys Ser 
            100                 105                 110         


Asn Gly Thr Ile Ala Leu Val Asp Asp Ser Glu Asp Pro Gly Ala Asn 
        115                 120                 125             


Val Ser Asn Ile Gln Leu Gln Gln Lys Ile Ser Ser Leu Glu Ile Lys 
    130                 135                 140                 


Leu Lys Val Ser Glu Glu Glu Lys Gln Arg Ile Lys Gln Asp Val Glu 
145                 150                 155                 160 


Ser Leu Met Glu Lys His Asn Val Leu Glu Lys Gly Phe Leu Lys Glu 
                165                 170                 175     


Lys Glu Gln Glu Ala Ile Ser Phe Gln Asp Arg Tyr Lys Glu Leu Gln 
            180                 185                 190         


Glu Lys His Lys Gln Glu Leu Glu Asp Met Arg Lys Ala Gly His Glu 
        195                 200                 205             


Ala Leu Ser Ile Ile Val Asp Glu Tyr Lys Ala Leu Leu Gln Ser Ser 
    210                 215                 220                 


Val Lys Gln Gln Val Glu Ala Ile Glu Lys Gln Tyr Ile Ser Ala Ile 
225                 230                 235                 240 


Glu Lys Gln Ala His Lys Cys Glu Glu Leu Leu Asn Ala Gln His Gln 
                245                 250                 255     


Arg Leu Leu Glu Met Leu Asp Thr Glu Lys Glu Leu Leu Lys Glu Lys 
            260                 265                 270         


Ile Lys Glu Ala Leu Ile Gln Gln Ser Gln Glu Gln Lys Glu Ile Leu 
        275                 280                 285             


Glu Lys Cys Leu Glu Glu Glu Arg Gln Arg Asn Lys Glu Ala Leu Val 
    290                 295                 300                 


Ser Ala Ala Lys Leu Glu Lys Glu Ala Val Lys Asp Ala Val Leu Lys 
305                 310                 315                 320 


Val Val Glu Glu Glu Arg Lys Asn Leu Glu Lys Ala His Ala Glu Glu 
                325                 330                 335     


Arg Glu Leu Trp Lys Thr Glu His Ala Lys Asp Gln Glu Lys Val Ser 
            340                 345                 350         


Gln Glu Ile Gln Lys Ala Ile Gln Glu Gln Arg Lys Ile Ser Gln Glu 
        355                 360                 365             


Thr Val Lys Ala Ala Ile Ile Glu Glu Gln Lys Arg Ser Glu Lys Ala 
    370                 375                 380                 


Val Glu Glu Ala Val Lys Arg Thr Arg Asp Glu Leu Ile Glu Tyr Ile 
385                 390                 395                 400 


Lys Glu Gln Lys Arg Leu Asp Gln Val Ile Arg Gln Arg Ser Leu Ser 
                405                 410                 415     


Ser Leu Glu Leu Phe Leu Ser Cys Ala Gln Lys Gln Leu Ser Ala Leu 
            420                 425                 430         


Ile Ala Thr Glu Pro Val Asp Ile Glu 
        435                 440     


<210>  1709
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC94__Homo_sapiens__NP_060544

<400>  1709

Met Ser Glu Arg Lys Val Leu Asn Lys Tyr Tyr Pro Pro Asp Phe Asp 
1               5                   10                  15      


Pro Ser Lys Ile Pro Lys Leu Lys Leu Pro Lys Asp Arg Gln Tyr Val 
            20                  25                  30          


Val Arg Leu Met Ala Pro Phe Asn Met Arg Cys Lys Thr Cys Gly Glu 
        35                  40                  45              


Tyr Ile Tyr Lys Gly Lys Lys Phe Asn Ala Arg Lys Glu Thr Val Gln 
    50                  55                  60                  


Asn Glu Val Tyr Leu Gly Leu Pro Ile Phe Arg Phe Tyr Ile Lys Cys 
65                  70                  75                  80  


Thr Arg Cys Leu Ala Glu Ile Thr Phe Lys Thr Asp Pro Glu Asn Thr 
                85                  90                  95      


Asp Tyr Thr Met Glu His Gly Ala Thr Arg Asn Phe Gln Ala Glu Lys 
            100                 105                 110         


Leu Leu Glu Glu Glu Glu Lys Arg Val Gln Lys Glu Arg Glu Asp Glu 
        115                 120                 125             


Glu Leu Asn Asn Pro Met Lys Val Leu Glu Asn Arg Thr Lys Asp Ser 
    130                 135                 140                 


Lys Leu Glu Met Glu Val Leu Glu Asn Leu Gln Glu Leu Lys Asp Leu 
145                 150                 155                 160 


Asn Gln Arg Gln Ala His Val Asp Phe Glu Ala Met Leu Arg Gln His 
                165                 170                 175     


Arg Leu Ser Glu Glu Glu Arg Arg Arg Gln Gln Gln Glu Glu Asp Glu 
            180                 185                 190         


Gln Glu Thr Ala Ala Leu Leu Glu Glu Ala Arg Lys Arg Arg Leu Leu 
        195                 200                 205             


Glu Asp Ser Asp Ser Glu Asp Glu Ala Ala Pro Ser Pro Leu Gln Pro 
    210                 215                 220                 


Ala Leu Arg Pro Asn Pro Thr Ala Ile Leu Asp Glu Ala Pro Lys Pro 
225                 230                 235                 240 


Lys Arg Lys Val Glu Val Trp Glu Gln Ser Val Gly Ser Leu Gly Ser 
                245                 250                 255     


Arg Pro Pro Leu Ser Arg Leu Val Val Val Lys Lys Ala Lys Ala Asp 
            260                 265                 270         


Pro Asp Cys Ser Asn Gly Gln Pro Gln Ala Ala Pro Thr Pro Gly Ala 
        275                 280                 285             


Pro Gln Asn Arg Lys Glu Ala Asn Pro Thr Pro Leu Thr Pro Gly Ala 
    290                 295                 300                 


Ser Ser Leu Ser Gln Leu Gly Ala Tyr Leu Asp Ser Asp Asp Ser Asn 
305                 310                 315                 320 


Gly Ser Asn 
            


<210>  1710
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCDC97__Homo_sapiens__NP_443080

<400>  1710

Met Glu Ala Val Ala Thr Ala Thr Ala Ala Lys Glu Pro Asp Lys Gly 
1               5                   10                  15      


Cys Ile Glu Pro Gly Pro Gly His Trp Gly Glu Leu Ser Arg Thr Pro 
            20                  25                  30          


Val Pro Ser Lys Pro Gln Asp Lys Val Glu Ala Ala Glu Ala Thr Pro 
        35                  40                  45              


Val Ala Leu Asp Ser Asp Thr Ser Gly Ala Glu Asn Ala Ala Val Ser 
    50                  55                  60                  


Ala Met Leu His Ala Val Ala Ala Ser Arg Leu Pro Val Cys Ser Gln 
65                  70                  75                  80  


Gln Gln Gly Glu Pro Asp Leu Thr Glu His Glu Lys Val Ala Ile Leu 
                85                  90                  95      


Ala Gln Leu Tyr His Glu Lys Pro Leu Val Phe Leu Glu Arg Phe Arg 
            100                 105                 110         


Thr Gly Leu Arg Glu Glu His Leu Ala Cys Phe Gly His Val Arg Gly 
        115                 120                 125             


Asp His Arg Ala Asp Phe Tyr Cys Ala Glu Val Ala Arg Gln Gly Thr 
    130                 135                 140                 


Ala Arg Pro Arg Thr Leu Arg Thr Arg Leu Arg Asn Arg Arg Tyr Ala 
145                 150                 155                 160 


Ala Leu Arg Glu Leu Ile Gln Gly Gly Glu Tyr Phe Ser Asp Glu Gln 
                165                 170                 175     


Met Arg Phe Arg Ala Pro Leu Leu Tyr Glu Gln Tyr Ile Gly Gln Tyr 
            180                 185                 190         


Leu Thr Gln Glu Glu Leu Ser Ala Arg Thr Pro Thr His Gln Pro Pro 
        195                 200                 205             


Lys Pro Gly Ser Pro Gly Arg Pro Ala Cys Pro Leu Ser Asn Leu Leu 
    210                 215                 220                 


Leu Gln Ser Tyr Glu Glu Arg Glu Leu Gln Gln Arg Leu Leu Gln Gln 
225                 230                 235                 240 


Gln Glu Glu Glu Glu Ala Cys Leu Glu Glu Glu Glu Glu Glu Glu Asp 
                245                 250                 255     


Ser Asp Glu Glu Asp Gln Arg Ser Gly Lys Asp Ser Glu Ala Trp Val 
            260                 265                 270         


Pro Asp Ser Glu Glu Arg Leu Ile Leu Arg Glu Glu Phe Thr Ser Arg 
        275                 280                 285             


Met His Gln Arg Phe Leu Asp Gly Lys Asp Gly Asp Phe Asp Tyr Ser 
    290                 295                 300                 


Thr Val Asp Asp Asn Pro Asp Phe Asp Asn Leu Asp Ile Val Ala Arg 
305                 310                 315                 320 


Asp Glu Glu Glu Arg Tyr Phe Asp Glu Glu Glu Pro Glu Asp Ala Pro 
                325                 330                 335     


Ser Pro Glu Leu Asp Gly Asp 
            340             


<210>  1711
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCHCR1__Homo_sapiens__NP_001099033

<400>  1711

Met Trp Pro His Ser Ala Gly Ala Arg Pro Trp Ala Ser Thr Leu Thr 
1               5                   10                  15      


Gly Lys Asp Pro Arg Val Met Ala Cys Trp Cys Leu Asp Gly Leu Pro 
            20                  25                  30          


Ser Gly Leu Ala Glu Pro Trp Arg Glu Leu Trp Arg Trp Arg Ser Arg 
        35                  40                  45              


Pro Leu His Cys Val Pro Pro Phe Ser Pro Leu Ala Arg Ser Ser Arg 
    50                  55                  60                  


Asp His Arg Asn Leu Arg Arg Arg Gly Asn Ile Asp Gly Trp Arg Gln 
65                  70                  75                  80  


Asn Leu Glu Pro Ser Asn Asn Val Glu Met Phe Pro Pro Ser Gly His 
                85                  90                  95      


Gln Asp Val Ser Glu Arg Arg Leu Asp Thr Gln Arg Pro Gln Val Thr 
            100                 105                 110         


Met Trp Glu Arg Asp Val Ser Ser Asp Arg Gln Glu Pro Gly Arg Arg 
        115                 120                 125             


Gly Arg Ser Trp Gly Leu Glu Gly Ser Gln Ala Leu Ser Gln Gln Ala 
    130                 135                 140                 


Glu Val Ile Val Arg Gln Leu Gln Glu Leu Arg Arg Leu Glu Glu Glu 
145                 150                 155                 160 


Val Arg Leu Leu Arg Glu Thr Ser Leu Gln Gln Lys Met Arg Leu Glu 
                165                 170                 175     


Ala Gln Ala Met Glu Leu Glu Ala Leu Ala Arg Ala Glu Lys Ala Gly 
            180                 185                 190         


Arg Ala Glu Ala Glu Gly Leu Arg Ala Ala Leu Ala Gly Ala Glu Val 
        195                 200                 205             


Val Arg Lys Asn Leu Glu Glu Gly Ser Gln Arg Glu Leu Glu Glu Val 
    210                 215                 220                 


Gln Arg Leu His Gln Glu Gln Leu Ser Ser Leu Thr Gln Ala His Glu 
225                 230                 235                 240 


Glu Ala Leu Ser Ser Leu Thr Ser Lys Ala Glu Gly Leu Glu Lys Ser 
                245                 250                 255     


Leu Ser Ser Leu Glu Thr Arg Arg Ala Gly Glu Ala Lys Glu Leu Ala 
            260                 265                 270         


Glu Ala Gln Arg Glu Ala Glu Leu Leu Arg Lys Gln Leu Ser Lys Thr 
        275                 280                 285             


Gln Glu Asp Leu Glu Ala Gln Val Thr Leu Val Glu Asn Leu Arg Lys 
    290                 295                 300                 


Tyr Val Gly Glu Gln Val Pro Ser Glu Val His Ser Gln Thr Trp Glu 
305                 310                 315                 320 


Leu Glu Arg Gln Lys Leu Leu Glu Thr Met Gln His Leu Gln Glu Asp 
                325                 330                 335     


Arg Asp Ser Leu His Ala Thr Ala Glu Leu Leu Gln Val Arg Val Gln 
            340                 345                 350         


Ser Leu Thr His Ile Leu Ala Leu Gln Glu Glu Glu Leu Thr Arg Lys 
        355                 360                 365             


Val Gln Pro Ser Asp Ser Leu Glu Pro Glu Phe Thr Arg Lys Cys Gln 
    370                 375                 380                 


Ser Leu Leu Asn Arg Trp Arg Glu Lys Val Phe Ala Leu Met Val Gln 
385                 390                 395                 400 


Leu Lys Ala Gln Glu Leu Glu His Ser Asp Ser Val Lys Gln Leu Lys 
                405                 410                 415     


Gly Gln Val Ala Ser Leu Gln Glu Lys Val Thr Ser Gln Ser Gln Glu 
            420                 425                 430         


Gln Ala Ile Leu Gln Arg Ser Leu Gln Asp Lys Ala Ala Glu Val Glu 
        435                 440                 445             


Val Glu Arg Met Gly Ala Lys Gly Leu Gln Leu Glu Leu Ser Arg Ala 
    450                 455                 460                 


Gln Glu Ala Arg Arg Arg Trp Gln Gln Gln Thr Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Gln Leu Arg Leu Val Val Asn Ala Val Ser Ser Ser Gln Ile Trp Leu 
                485                 490                 495     


Glu Thr Thr Met Ala Lys Val Glu Gly Ala Ala Ala Gln Leu Pro Ser 
            500                 505                 510         


Leu Asn Asn Arg Leu Ser Tyr Ala Val Arg Lys Val His Thr Ile Arg 
        515                 520                 525             


Gly Leu Ile Ala Arg Lys Leu Ala Leu Ala Gln Leu Arg Gln Glu Ser 
    530                 535                 540                 


Cys Pro Leu Pro Pro Pro Val Thr Asp Val Ser Leu Glu Leu Gln Gln 
545                 550                 555                 560 


Leu Arg Glu Glu Arg Asn Arg Leu Asp Ala Glu Leu Gln Leu Ser Ala 
                565                 570                 575     


Arg Leu Ile Gln Gln Glu Val Gly Arg Ala Arg Glu Gln Gly Glu Ala 
            580                 585                 590         


Glu Arg Gln Gln Leu Ser Lys Val Ala Gln Gln Leu Glu Gln Glu Leu 
        595                 600                 605             


Gln Gln Thr Gln Glu Ser Leu Ala Ser Leu Gly Leu Gln Leu Glu Val 
    610                 615                 620                 


Ala Arg Gln Gly Gln Gln Glu Ser Thr Glu Glu Ala Ala Ser Leu Arg 
625                 630                 635                 640 


Gln Glu Leu Thr Gln Gln Gln Glu Leu Tyr Gly Gln Ala Leu Gln Glu 
                645                 650                 655     


Lys Val Ala Glu Val Glu Thr Arg Leu Arg Glu Gln Leu Ser Asp Thr 
            660                 665                 670         


Glu Arg Arg Leu Asn Glu Ala Arg Arg Glu His Ala Lys Ala Val Val 
        675                 680                 685             


Ser Leu Arg Gln Ile Gln Arg Arg Ala Ala Gln Glu Lys Glu Arg Ser 
    690                 695                 700                 


Gln Glu Leu Arg Arg Leu Gln Glu Glu Ala Arg Lys Glu Glu Gly Gln 
705                 710                 715                 720 


Arg Leu Ala Arg Arg Leu Gln Glu Leu Glu Arg Asp Lys Asn Leu Met 
                725                 730                 735     


Leu Ala Thr Leu Gln Gln Glu Gly Leu Leu Ser Arg Tyr Lys Gln Gln 
            740                 745                 750         


Arg Leu Leu Thr Val Leu Pro Ser Leu Leu Asp Lys Lys Lys Ser Val 
        755                 760                 765             


Val Ser Ser Pro Arg Pro Pro Glu Cys Ser Ala Ser Ala Pro Val Ala 
    770                 775                 780                 


Ala Ala Val Pro Thr Arg Glu Ser Ile Lys Gly Ser Leu Ser Val Leu 
785                 790                 795                 800 


Leu Asp Asp Leu Gln Asp Leu Ser Glu Ala Ile Ser Lys Glu Glu Ala 
                805                 810                 815     


Val Cys Gln Gly Asp Asn Leu Asp Arg Cys Ser Ser Ser Asn Pro Gln 
            820                 825                 830         


Met Ser Ser 
        835 


<210>  1712
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCKAR__Homo_sapiens__NP_000721

<400>  1712

Met Asp Val Val Asp Ser Leu Leu Val Asn Gly Ser Asn Ile Thr Pro 
1               5                   10                  15      


Pro Cys Glu Leu Gly Leu Glu Asn Glu Thr Leu Phe Cys Leu Asp Gln 
            20                  25                  30          


Pro Arg Pro Ser Lys Glu Trp Gln Pro Ala Val Gln Ile Leu Leu Tyr 
        35                  40                  45              


Ser Leu Ile Phe Leu Leu Ser Val Leu Gly Asn Thr Leu Val Ile Thr 
    50                  55                  60                  


Val Leu Ile Arg Asn Lys Arg Met Arg Thr Val Thr Asn Ile Phe Leu 
65                  70                  75                  80  


Leu Ser Leu Ala Val Ser Asp Leu Met Leu Cys Leu Phe Cys Met Pro 
                85                  90                  95      


Phe Asn Leu Ile Pro Asn Leu Leu Lys Asp Phe Ile Phe Gly Ser Ala 
            100                 105                 110         


Val Cys Lys Thr Thr Thr Tyr Phe Met Gly Thr Ser Val Ser Val Ser 
        115                 120                 125             


Thr Phe Asn Leu Val Ala Ile Ser Leu Glu Arg Tyr Gly Ala Ile Cys 
    130                 135                 140                 


Lys Pro Leu Gln Ser Arg Val Trp Gln Thr Lys Ser His Ala Leu Lys 
145                 150                 155                 160 


Val Ile Ala Ala Thr Trp Cys Leu Ser Phe Thr Ile Met Thr Pro Tyr 
                165                 170                 175     


Pro Ile Tyr Ser Asn Leu Val Pro Phe Thr Lys Asn Asn Asn Gln Thr 
            180                 185                 190         


Ala Asn Met Cys Arg Phe Leu Leu Pro Asn Asp Val Met Gln Gln Ser 
        195                 200                 205             


Trp His Thr Phe Leu Leu Leu Ile Leu Phe Leu Ile Pro Gly Ile Val 
    210                 215                 220                 


Met Met Val Ala Tyr Gly Leu Ile Ser Leu Glu Leu Tyr Gln Gly Ile 
225                 230                 235                 240 


Lys Phe Glu Ala Ser Gln Lys Lys Ser Ala Lys Glu Arg Lys Pro Ser 
                245                 250                 255     


Thr Thr Ser Ser Gly Lys Tyr Glu Asp Ser Asp Gly Cys Tyr Leu Gln 
            260                 265                 270         


Lys Thr Arg Pro Pro Arg Lys Leu Glu Leu Arg Gln Leu Ser Thr Gly 
        275                 280                 285             


Ser Ser Ser Arg Ala Asn Arg Ile Arg Ser Asn Ser Ser Ala Ala Asn 
    290                 295                 300                 


Leu Met Ala Lys Lys Arg Val Ile Arg Met Leu Ile Val Ile Val Val 
305                 310                 315                 320 


Leu Phe Phe Leu Cys Trp Met Pro Ile Phe Ser Ala Asn Ala Trp Arg 
                325                 330                 335     


Ala Tyr Asp Thr Ala Ser Ala Glu Arg Arg Leu Ser Gly Thr Pro Ile 
            340                 345                 350         


Ser Phe Ile Leu Leu Leu Ser Tyr Thr Ser Ser Cys Val Asn Pro Ile 
        355                 360                 365             


Ile Tyr Cys Phe Met Asn Lys Arg Phe Arg Leu Gly Phe Met Ala Thr 
    370                 375                 380                 


Phe Pro Cys Cys Pro Asn Pro Gly Pro Pro Gly Ala Arg Gly Glu Val 
385                 390                 395                 400 


Gly Glu Glu Glu Glu Gly Gly Thr Thr Gly Ala Ser Leu Ser Arg Phe 
                405                 410                 415     


Ser Tyr Ser His Met Ser Ala Ser Val Pro Pro Gln 
            420                 425             


<210>  1713
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCKBR__Homo_sapiens__NP_795344

<400>  1713

Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Thr Gly Pro Gly 
1               5                   10                  15      


Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 
            20                  25                  30          


Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 
        35                  40                  45              


Thr Arg Glu Leu Glu Leu Ala Ile Arg Ile Thr Leu Tyr Ala Val Ile 
    50                  55                  60                  


Phe Leu Met Ser Val Gly Gly Asn Met Leu Ile Ile Val Val Leu Gly 
65                  70                  75                  80  


Leu Ser Arg Arg Leu Arg Thr Val Thr Asn Ala Phe Leu Leu Ser Leu 
                85                  90                  95      


Ala Val Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Thr Leu 
            100                 105                 110         


Leu Pro Asn Leu Met Gly Thr Phe Ile Phe Gly Thr Val Ile Cys Lys 
        115                 120                 125             


Ala Val Ser Tyr Leu Met Gly Val Ser Val Ser Val Ser Thr Leu Ser 
    130                 135                 140                 


Leu Val Ala Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys Arg Pro Leu 
145                 150                 155                 160 


Gln Ala Arg Val Trp Gln Thr Arg Ser His Ala Ala Arg Val Ile Val 
                165                 170                 175     


Ala Thr Trp Leu Leu Ser Gly Leu Leu Met Val Pro Tyr Pro Val Tyr 
            180                 185                 190         


Thr Val Val Gln Pro Val Gly Pro Arg Val Leu Gln Cys Val His Arg 
        195                 200                 205             


Trp Pro Ser Ala Arg Val Arg Gln Thr Trp Ser Val Leu Leu Leu Leu 
    210                 215                 220                 


Leu Leu Phe Phe Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu 
225                 230                 235                 240 


Ile Ser Arg Glu Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp 
                245                 250                 255     


Ser Asp Ser Gln Ser Arg Val Arg Asn Gln Gly Gly Leu Pro Gly Ala 
            260                 265                 270         


Val His Gln Asn Gly Arg Cys Arg Pro Glu Thr Gly Ala Val Gly Glu 
        275                 280                 285             


Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro Arg Ser Arg Pro Ala Leu 
    290                 295                 300                 


Glu Leu Thr Ala Leu Thr Ala Pro Gly Pro Gly Ser Gly Ser Arg Pro 
305                 310                 315                 320 


Thr Gln Ala Lys Leu Leu Ala Lys Lys Arg Val Val Arg Met Leu Leu 
                325                 330                 335     


Val Ile Val Val Leu Phe Phe Leu Cys Trp Leu Pro Val Tyr Ser Ala 
            340                 345                 350         


Asn Thr Trp Arg Ala Phe Asp Gly Pro Gly Ala His Arg Ala Leu Ser 
        355                 360                 365             


Gly Ala Pro Ile Ser Phe Ile His Leu Leu Ser Tyr Ala Ser Ala Cys 
    370                 375                 380                 


Val Asn Pro Leu Val Tyr Cys Phe Met His Arg Arg Phe Arg Gln Ala 
385                 390                 395                 400 


Cys Leu Glu Thr Cys Ala Arg Cys Cys Pro Arg Pro Pro Arg Ala Arg 
                405                 410                 415     


Pro Arg Ala Leu Pro Asp Glu Asp Pro Pro Thr Pro Ser Ile Ala Ser 
            420                 425                 430         


Leu Ser Arg Leu Ser Tyr Thr Thr Ile Ser Thr Leu Gly Pro Gly 
        435                 440                 445         


<210>  1714
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCK__Homo_sapiens__NP_000720

<400>  1714

Met Asn Ser Gly Val Cys Leu Cys Val Leu Met Ala Val Leu Ala Ala 
1               5                   10                  15      


Gly Ala Leu Thr Gln Pro Val Pro Pro Ala Asp Pro Ala Gly Ser Gly 
            20                  25                  30          


Leu Gln Arg Ala Glu Glu Ala Pro Arg Arg Gln Leu Arg Val Ser Gln 
        35                  40                  45              


Arg Thr Asp Gly Glu Ser Arg Ala His Leu Gly Ala Leu Leu Ala Arg 
    50                  55                  60                  


Tyr Ile Gln Gln Ala Arg Lys Ala Pro Ser Gly Arg Met Ser Ile Val 
65                  70                  75                  80  


Lys Asn Leu Gln Asn Leu Asp Pro Ser His Arg Ile Ser Asp Arg Asp 
                85                  90                  95      


Tyr Met Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Glu Tyr Glu 
            100                 105                 110         


Tyr Pro Ser 
        115 


<210>  1715
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL11__Homo_sapiens__NP_002977

<400>  1715

Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Thr Thr Cys 
            20                  25                  30          


Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 
        35                  40                  45              


Tyr Arg Arg Ile Thr Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 
    50                  55                  60                  


Lys Thr Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 
65                  70                  75                  80  


Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Thr Pro Lys 
                85                  90                  95      


Pro 
    


<210>  1716
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL13__Homo_sapiens__NP_005399

<400>  1716

Met Lys Val Ser Ala Val Leu Leu Cys Leu Leu Leu Met Thr Ala Ala 
1               5                   10                  15      


Phe Asn Pro Gln Gly Leu Ala Gln Pro Asp Ala Leu Asn Val Pro Ser 
            20                  25                  30          


Thr Cys Cys Phe Thr Phe Ser Ser Lys Lys Ile Ser Leu Gln Arg Leu 
        35                  40                  45              


Lys Ser Tyr Val Ile Thr Thr Ser Arg Cys Pro Gln Lys Ala Val Ile 
    50                  55                  60                  


Phe Arg Thr Lys Leu Gly Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys 
65                  70                  75                  80  


Trp Val Gln Asn Tyr Met Lys His Leu Gly Arg Lys Ala His Thr Leu 
                85                  90                  95      


Lys Thr 
        


<210>  1717
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL14__Homo_sapiens__NP_116738

<400>  1717

Met Lys Ile Ser Val Ala Ala Ile Pro Phe Phe Leu Leu Ile Thr Ile 
1               5                   10                  15      


Ala Leu Gly Thr Lys Thr Glu Ser Ser Ser Gln Thr Gly Gly Lys Pro 
            20                  25                  30          


Lys Val Val Lys Ile Gln Leu Lys Leu Val Gly Gly Pro Tyr His Pro 
        35                  40                  45              


Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys Ile Pro Arg Gln Arg 
    50                  55                  60                  


Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys Ser Lys Pro Gly Ile 
65                  70                  75                  80  


Val Phe Ile Thr Lys Arg Gly His Ser Val Cys Thr Asn Pro Ser Asp 
                85                  90                  95      


Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys Glu Asn 
            100                 105                 


<210>  1718
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL15__Homo_sapiens__NP_116741

<400>  1718

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Ala Val 
1               5                   10                  15      


Leu Gly Ser Gln Ala Gln Phe Thr Asn Asp Ala Glu Thr Glu Leu Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Val Leu Asn Ser Phe His 
        35                  40                  45              


Phe Ala Ala Asp Cys Cys Thr Ser Tyr Ile Ser Gln Ser Ile Pro Cys 
    50                  55                  60                  


Ser Leu Met Lys Ser Tyr Phe Glu Thr Ser Ser Glu Cys Ser Lys Pro 
65                  70                  75                  80  


Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Gln Val Cys Ala Lys Pro 
                85                  90                  95      


Ser Gly Pro Gly Val Gln Asp Cys Met Lys Lys Leu Lys Pro Tyr Ser 
            100                 105                 110         


Ile 
    


<210>  1719
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL16__Homo_sapiens__XP_005258077

<400>  1719

Met Lys Val Ser Glu Ala Ala Leu Ser Leu Leu Val Leu Ile Leu Ile 
1               5                   10                  15      


Ile Thr Ser Ala Ser Arg Ser Gln Pro Lys Val Pro Glu Trp Val Asn 
            20                  25                  30          


Thr Pro Ser Thr Cys Cys Leu Lys Tyr Tyr Glu Lys Val Leu Pro Arg 
        35                  40                  45              


Arg Leu Val Val Gly Tyr Arg Lys Ala Leu Asn Cys His Leu Pro Ala 
    50                  55                  60                  


Ile Ile Phe Val Thr Lys Arg Asn Arg Glu Val Cys Thr Asn Pro Asn 
65                  70                  75                  80  


Asp Asp Trp Val Gln Glu Tyr Ile Lys Asp Pro Asn Leu Pro Leu Leu 
                85                  90                  95      


Pro Thr Arg Asn Leu Ser Thr Val Lys Ile Ile Thr Ala Lys Asn Gly 
            100                 105                 110         


Gln Pro Gln Leu Leu Asn Ser Gln 
        115                 120 


<210>  1720
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL17__Homo_sapiens__NP_002978

<400>  1720

Met Ala Pro Leu Lys Met Leu Ala Leu Val Thr Leu Leu Leu Gly Ala 
1               5                   10                  15      


Ser Leu Gln His Ile His Ala Ala Arg Gly Thr Asn Val Gly Arg Glu 
            20                  25                  30          


Cys Cys Leu Glu Tyr Phe Lys Gly Ala Ile Pro Leu Arg Lys Leu Lys 
        35                  40                  45              


Thr Trp Tyr Gln Thr Ser Glu Asp Cys Ser Arg Asp Ala Ile Val Phe 
    50                  55                  60                  


Val Thr Val Gln Gly Arg Ala Ile Cys Ser Asp Pro Asn Asn Lys Arg 
65                  70                  75                  80  


Val Lys Asn Ala Val Lys Tyr Leu Gln Ser Leu Glu Arg Ser 
                85                  90                  


<210>  1721
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL18__Homo_sapiens__NP_002979

<400>  1721

Met Lys Gly Leu Ala Ala Ala Leu Leu Val Leu Val Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Ser Cys Ala Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu 
            20                  25                  30          


Val Tyr Thr Ser Trp Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser 
        35                  40                  45              


Glu Thr Ser Pro Gln Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys 
    50                  55                  60                  


Arg Gly Arg Gln Ile Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys 
65                  70                  75                  80  


Tyr Ile Ser Asp Leu Lys Leu Asn Ala 
                85                  


<210>  1722
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL19__Homo_sapiens__NP_006265

<400>  1722

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  1723
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL1__Homo_sapiens__NP_002972

<400>  1723

Met Gln Ile Ile Thr Thr Ala Leu Val Cys Leu Leu Leu Ala Gly Met 
1               5                   10                  15      


Trp Pro Glu Asp Val Asp Ser Lys Ser Met Gln Val Pro Phe Ser Arg 
            20                  25                  30          


Cys Cys Phe Ser Phe Ala Glu Gln Glu Ile Pro Leu Arg Ala Ile Leu 
        35                  40                  45              


Cys Tyr Arg Asn Thr Ser Ser Ile Cys Ser Asn Glu Gly Leu Ile Phe 
    50                  55                  60                  


Lys Leu Lys Arg Gly Lys Glu Ala Cys Ala Leu Asp Thr Val Gly Trp 
65                  70                  75                  80  


Val Gln Arg His Arg Lys Met Leu Arg His Cys Pro Ser Lys Arg Lys 
                85                  90                  95      


<210>  1724
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL20__Homo_sapiens__NP_001123518

<400>  1724

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95  


<210>  1725
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL21__Homo_sapiens__NP_002980

<400>  1725

Met Ala Gln Ser Leu Ala Leu Ser Leu Leu Ile Leu Val Leu Ala Phe 
1               5                   10                  15      


Gly Ile Pro Arg Thr Gln Gly Ser Asp Gly Gly Ala Gln Asp Cys Cys 
            20                  25                  30          


Leu Lys Tyr Ser Gln Arg Lys Ile Pro Ala Lys Val Val Arg Ser Tyr 
        35                  40                  45              


Arg Lys Gln Glu Pro Ser Leu Gly Cys Ser Ile Pro Ala Ile Leu Phe 
    50                  55                  60                  


Leu Pro Arg Lys Arg Ser Gln Ala Glu Leu Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Leu Trp Val Gln Gln Leu Met Gln His Leu Asp Lys Thr Pro Ser Pro 
                85                  90                  95      


Gln Lys Pro Ala Gln Gly Cys Arg Lys Asp Arg Gly Ala Ser Lys Thr 
            100                 105                 110         


Gly Lys Lys Gly Lys Gly Ser Lys Gly Cys Lys Arg Thr Glu Arg Ser 
        115                 120                 125             


Gln Thr Pro Lys Gly Pro 
    130                 


<210>  1726
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL22__Homo_sapiens__NP_002981

<400>  1726

Met Asp Arg Leu Gln Thr Ala Leu Leu Val Val Leu Val Leu Leu Ala 
1               5                   10                  15      


Val Ala Leu Gln Ala Thr Glu Ala Gly Pro Tyr Gly Ala Asn Met Glu 
            20                  25                  30          


Asp Ser Val Cys Cys Arg Asp Tyr Val Arg Tyr Arg Leu Pro Leu Arg 
        35                  40                  45              


Val Val Lys His Phe Tyr Trp Thr Ser Asp Ser Cys Pro Arg Pro Gly 
    50                  55                  60                  


Val Val Leu Leu Thr Phe Arg Asp Lys Glu Ile Cys Ala Asp Pro Arg 
65                  70                  75                  80  


Val Pro Trp Val Lys Met Ile Leu Asn Lys Leu Ser Gln 
                85                  90              


<210>  1727
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL23__Homo_sapiens__NP_005055

<400>  1727

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala Arg Val Thr Lys Asp Ala Glu Thr Glu Phe Met 
            20                  25                  30          


Met Ser Lys Leu Pro Leu Glu Asn Pro Val Leu Leu Asp Met Leu Trp 
        35                  40                  45              


Arg Arg Lys Ile Gly Pro Gln Met Thr Leu Ser His Ala Ala Gly Phe 
    50                  55                  60                  


His Ala Thr Ser Ala Asp Cys Cys Ile Ser Tyr Thr Pro Arg Ser Ile 
65                  70                  75                  80  


Pro Cys Ser Leu Leu Glu Ser Tyr Phe Glu Thr Asn Ser Glu Cys Ser 
                85                  90                  95      


Lys Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Arg Phe Cys Ala 
            100                 105                 110         


Asn Pro Ser Asp Lys Gln Val Gln Val Cys Met Arg Met Leu Lys Leu 
        115                 120                 125             


Asp Thr Arg Ile Lys Thr Arg Lys Asn 
    130                 135         


<210>  1728
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL24__Homo_sapiens__XP_011514762

<400>  1728

Met Ala Gly Leu Met Thr Ile Val Thr Ser Leu Leu Phe Leu Gly Val 
1               5                   10                  15      


Cys Ala His His Ile Ile Pro Thr Gly Ser Val Val Ile Pro Ser Pro 
            20                  25                  30          


Cys Cys Met Phe Phe Val Ser Lys Arg Ile Pro Glu Asn Arg Val Val 
        35                  40                  45              


Ser Tyr Gln Leu Ser Ser Arg Ser Thr Cys Leu Lys Ala Gly Val Ile 
    50                  55                  60                  


Phe Thr Thr Lys Lys Gly Gln Gln Phe Cys Gly Asp Pro Lys Gln Glu 
65                  70                  75                  80  


Trp Val Gln Arg Tyr Met Lys Asn Leu Asp Ala Lys Gln Lys Lys Ala 
                85                  90                  95      


Ser Pro Arg Ala Arg Ala Val Ala Val Lys Gly Pro Val Gln Arg Tyr 
            100                 105                 110         


Pro Gly Asn Gln Thr Thr Cys 
        115                 


<210>  1729
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL25__Homo_sapiens__NP_001188288

<400>  1729

Met Asn Leu Trp Leu Leu Ala Cys Leu Val Ala Gly Phe Leu Gly Ala 
1               5                   10                  15      


Trp Ala Pro Ala Val His Thr Gln Gly Val Phe Glu Asp Cys Cys Leu 
            20                  25                  30          


Ala Tyr His Tyr Pro Ile Gly Trp Ala Val Leu Arg Arg Ala Trp Thr 
        35                  40                  45              


Tyr Arg Ile Gln Glu Val Ser Gly Ser Cys Asn Leu Pro Ala Ala Ile 
    50                  55                  60                  


Phe Tyr Leu Pro Lys Arg His Arg Lys Val Cys Gly Asn Pro Lys Ser 
65                  70                  75                  80  


Arg Glu Val Gln Arg Ala Met Lys Leu Leu Asp Ala Arg Asn Lys Val 
                85                  90                  95      


Phe Ala Lys Leu His His Asn Thr Gln Thr Phe Gln Gly Pro His Ala 
            100                 105                 110         


Val Lys Lys Leu Ser Ser Gly Asn Ser Lys Leu Ser Ser Ser Lys Phe 
        115                 120                 125             


Ser Asn Pro Ile Ser Ser Ser Lys Arg Asn Val Ser Leu Leu Ile Ser 
    130                 135                 140                 


Ala Asn Ser Gly Leu 
145                 


<210>  1730
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL26__Homo_sapiens__NP_006063

<400>  1730

Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Thr Thr Lys Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu 
                85                  90                  


<210>  1731
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL27__Homo_sapiens__NP_006655

<400>  1731

Met Lys Gly Pro Pro Thr Phe Cys Ser Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Ser Pro Asp Pro Thr Ala Ala Phe Leu Leu Pro Pro Ser Thr Ala 
            20                  25                  30          


Cys Cys Thr Gln Leu Tyr Arg Lys Pro Leu Ser Asp Lys Leu Leu Arg 
        35                  40                  45              


Lys Val Ile Gln Val Glu Leu Gln Glu Ala Asp Gly Asp Cys His Leu 
    50                  55                  60                  


Gln Ala Phe Val Leu His Leu Ala Gln Arg Ser Ile Cys Ile His Pro 
65                  70                  75                  80  


Gln Asn Pro Ser Leu Ser Gln Trp Phe Glu His Gln Glu Arg Lys Leu 
                85                  90                  95      


His Gly Thr Leu Pro Lys Leu Asn Phe Gly Met Leu Arg Lys Met Gly 
            100                 105                 110         


<210>  1732
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL28__Homo_sapiens__NP_001288802

<400>  1732

Met Gln Gln Arg Gly Leu Ala Ile Val Ala Leu Ala Val Cys Ala Ala 
1               5                   10                  15      


Leu His Ala Ser Glu Ala Ile Leu Pro Ile Ala Ser Ser Cys Cys Thr 
            20                  25                  30          


Glu Val Ser His His Ile Ser Arg Arg Leu Leu Glu Arg Val Asn Met 
        35                  40                  45              


Cys Arg Ile Gln Arg Ala Asp Gly Asp Cys Asp Leu Ala Ala Val Ile 
    50                  55                  60                  


Leu His Val Lys Arg Arg Arg Ile Cys Val Ser Pro His Asn His Thr 
65                  70                  75                  80  


Val Lys Gln Trp Met Lys Val Gln Ala Ala Lys Lys Asn Gly Lys Gly 
                85                  90                  95      


Asn Val Cys His Arg Lys Lys His His Gly Lys Arg Asn Ser Asn Arg 
            100                 105                 110         


Ala His Gln Gly Lys His Glu Thr Tyr Gly His Lys Thr Pro Tyr 
        115                 120                 125         


<210>  1733
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL2__Homo_sapiens__NP_002973

<400>  1733

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210>  1734
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL3__Homo_sapiens__NP_002974

<400>  1734

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210>  1735
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL3L3__Homo_sapiens__NP_001001437

<400>  1735

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  1736
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL4__Homo_sapiens__NP_002975

<400>  1736

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  1737
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL4L1__Homo_sapiens__NP_996890

<400>  1737

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  1738
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL4L2__Homo_sapiens__NP_001278397

<400>  1738

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Val Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Leu Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Gly Lys Gln Val Cys Ala Asp Pro Ser Glu Ser Trp Val Gln Glu Tyr 
65                  70                  75                  80  


Val Tyr Asp Leu Glu Leu Asn 
                85          


<210>  1739
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL5__Homo_sapiens__NP_001265665

<400>  1739

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val His 
    50                  55                  60                  


Arg Ser Arg Met Pro Lys Arg Glu Gly Gln Gln Val Trp Gln Asp Phe 
65                  70                  75                  80  


Leu Tyr Asp Ser Arg Leu Asn Lys Gly Lys Leu Cys His Pro Lys Glu 
                85                  90                  95      


Pro Pro Ser Val Cys Gln Pro Arg Glu Glu Met Gly Ser Gly Val His 
            100                 105                 110         


Gln Leu Phe Gly Asp Glu Leu Gly Trp Arg Val Leu Glu Pro Glu Leu 
        115                 120                 125             


Thr Gln Ile Cys Leu Phe Leu Leu Ala Leu Val Leu Ala Trp Glu Ala 
    130                 135                 140                 


Ser Pro His Tyr Pro Thr Pro Pro Ala Pro 
145                 150                 


<210>  1740
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL7__Homo_sapiens__NP_006264

<400>  1740

Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr 
            20                  25                  30          


Thr Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr 
                85                  90                  95      


Pro Lys Leu 
            


<210>  1741
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCL8__Homo_sapiens__NP_005614

<400>  1741

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Met Ala Ala Thr 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Asp Ser Val Ser Ile Pro Ile 
            20                  25                  30          


Thr Cys Cys Phe Asn Val Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Thr Arg Ile Thr Asn Ile Gln Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Arg Gly Lys Glu Val Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Arg Trp Val Arg Asp Ser Met Lys His Leu Asp Gln Ile Phe Gln Asn 
                85                  90                  95      


Leu Lys Pro 
            


<210>  1742
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCM2__Homo_sapiens__NP_001025006

<400>  1742

Met His Ser Ser Cys Arg Gln Arg Arg Asn Gln Asn Leu Ser Lys Glu 
1               5                   10                  15      


Ile Pro Gln Thr Glu Phe His Thr Gly Tyr Ser Met Glu Asn Glu Pro 
            20                  25                  30          


Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser 
        35                  40                  45              


Arg Asp Lys Lys Ala His Glu Lys Val Thr Glu Arg Arg Pro Leu His 
    50                  55                  60                  


Thr Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser 
                85                  90                  95      


Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe 
            100                 105                 110         


Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr Gln 
        115                 120                 125             


Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala 
    130                 135                 140                 


Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile 
145                 150                 155                 160 


Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val Leu 
                165                 170                 175     


Lys Thr Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala 
            180                 185                 190         


Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val 
        195                 200                 205             


Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys 
    210                 215                 220                 


Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val 
225                 230                 235                 240 


Val Tyr Thr Glu Ser Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp 
                245                 250                 255     


Gly Ala Ser Thr Pro Thr His His Leu Ser Leu His Ser Asp Asp Ser 
            260                 265                 270         


Ser Thr Lys Val Asp Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr 
        275                 280                 285             


Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His Ser 
    290                 295                 300                 


Lys Thr Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu Leu 
305                 310                 315                 320 


Gln Asp Tyr Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile 
                325                 330                 335     


Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile 
            340                 345                 350         


His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys 
        355                 360                 365             


Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln 
    370                 375                 380                 


His Phe Glu Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly 
385                 390                 395                 400 


Ile Ile Thr Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr 
                405                 410                 415     


Ser Ser Ser Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp 
            420                 425                 430         


Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp 
        435                 440                 445             


Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser 
    450                 455                 460                 


Ala 
465 


<210>  1743
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNA1__Homo_sapiens__NP_001104515

<400>  1743

Met Glu Thr Gly Phe Pro Ala Ile Met Tyr Pro Gly Ser Phe Ile Gly 
1               5                   10                  15      


Gly Trp Gly Glu Glu Tyr Leu Ser Trp Glu Gly Pro Gly Leu Pro Asp 
            20                  25                  30          


Phe Val Phe Gln Gln Pro Val Glu Ser Glu Ala Met His Cys Ser Asn 
        35                  40                  45              


Pro Lys Ser Gly Val Val Leu Ala Thr Val Ala Arg Gly Pro Asp Ala 
    50                  55                  60                  


Cys Gln Ile Leu Thr Arg Ala Pro Leu Gly Gln Asp Pro Pro Gln Arg 
65                  70                  75                  80  


Thr Val Leu Gly Leu Leu Thr Ala Asn Gly Gln Tyr Arg Arg Thr Cys 
                85                  90                  95      


Gly Gln Gly Ile Thr Arg Ile Arg Cys Tyr Ser Gly Ser Glu Asn Ala 
            100                 105                 110         


Phe Pro Pro Ala Gly Lys Lys Ala Leu Pro Asp Cys Gly Val Gln Glu 
        115                 120                 125             


Pro Pro Lys Gln Gly Phe Asp Ile Tyr Met Asp Glu Leu Glu Gln Gly 
    130                 135                 140                 


Asp Arg Asp Ser Cys Ser Val Arg Glu Gly Met Ala Phe Glu Asp Val 
145                 150                 155                 160 


Tyr Glu Val Asp Thr Gly Thr Leu Lys Ser Asp Leu His Phe Leu Leu 
                165                 170                 175     


Asp Phe Asn Thr Val Ser Pro Met Leu Val Asp Ser Ser Leu Leu Ser 
            180                 185                 190         


Gln Ser Glu Asp Ile Ser Ser Leu Gly Thr Asp Val Ile Asn Val Thr 
        195                 200                 205             


Glu Tyr Ala Glu Glu Ile Tyr Gln Tyr Leu Arg Glu Ala Glu Ile Arg 
    210                 215                 220                 


His Arg Pro Lys Ala His Tyr Met Lys Lys Gln Pro Asp Ile Thr Glu 
225                 230                 235                 240 


Gly Met Arg Thr Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 
                245                 250                 255     


Tyr Lys Leu Arg Ala Glu Thr Leu Tyr Leu Ala Val Asn Phe Leu Asp 
            260                 265                 270         


Arg Phe Leu Ser Cys Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 
        275                 280                 285             


Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Tyr Glu Glu Ile Tyr Pro 
    290                 295                 300                 


Pro Glu Val Asp Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys 
305                 310                 315                 320 


Arg Gln Leu Leu Lys Met Glu His Leu Leu Leu Lys Val Leu Ala Phe 
                325                 330                 335     


Asp Leu Thr Val Pro Thr Thr Asn Gln Phe Leu Leu Gln Tyr Leu Arg 
            340                 345                 350         


Arg Gln Gly Val Cys Val Arg Thr Glu Asn Leu Ala Lys Tyr Val Ala 
        355                 360                 365             


Glu Leu Ser Leu Leu Glu Ala Asp Pro Phe Leu Lys Tyr Leu Pro Ser 
    370                 375                 380                 


Leu Ile Ala Ala Ala Ala Phe Cys Leu Ala Asn Tyr Thr Val Asn Lys 
385                 390                 395                 400 


His Phe Trp Pro Glu Thr Leu Ala Ala Phe Thr Gly Tyr Ser Leu Ser 
                405                 410                 415     


Glu Ile Val Pro Cys Leu Ser Glu Leu His Lys Ala Tyr Leu Asp Ile 
            420                 425                 430         


Pro His Arg Pro Gln Gln Ala Ile Arg Glu Lys Tyr Lys Ala Ser Lys 
        435                 440                 445             


Tyr Leu Cys Val Ser Leu Met Glu Pro Pro Ala Val Leu Leu Leu Gln 
    450                 455                 460                 


<210>  1744
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNA2__Homo_sapiens__NP_001228

<400>  1744

Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly Ser 
1               5                   10                  15      


Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu Asn 
            20                  25                  30          


Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr Arg Ala 
        35                  40                  45              


Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 
    50                  55                  60                  


Gln Arg Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 
65                  70                  75                  80  


Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 
                85                  90                  95      


Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 
            100                 105                 110         


Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 
        115                 120                 125             


Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 
    130                 135                 140                 


Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp Met 
145                 150                 155                 160 


Ser Ile Val Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val Pro 
                165                 170                 175     


Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val Lys 
            180                 185                 190         


Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr Asn 
        195                 200                 205             


Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 
    210                 215                 220                 


Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile Asp 
225                 230                 235                 240 


Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 
                245                 250                 255     


Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 
            260                 265                 270         


Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys 
        275                 280                 285             


Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Thr Phe 
    290                 295                 300                 


Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe Leu 
305                 310                 315                 320 


His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 
                325                 330                 335     


Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 
            340                 345                 350         


Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val Thr 
        355                 360                 365             


Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr Leu 
    370                 375                 380                 


Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu Lys 
385                 390                 395                 400 


Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn Ser 
                405                 410                 415     


Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr Leu Asn Leu 
            420                 425                 430         


<210>  1745
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNB1__Homo_sapiens__NP_114172

<400>  1745

Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala 
            20                  25                  30          


Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr 
    210                 215                 220                 


Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr 
        355                 360                 365             


Leu Ser Tyr Thr Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala 
    370                 375                 380                 


Lys Asn Val Val Met Val Asn Gln Gly Leu Thr Lys His Met Thr Val 
385                 390                 395                 400 


Lys Asn Lys Tyr Ala Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro 
                405                 410                 415     


Gln Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys 
            420                 425                 430         


Val 
    


<210>  1746
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNB2__Homo_sapiens__NP_004692

<400>  1746

Met Ala Leu Leu Arg Arg Pro Thr Val Ser Ser Asp Leu Glu Asn Ile 
1               5                   10                  15      


Asp Thr Gly Val Asn Ser Lys Val Lys Ser His Val Thr Ile Arg Arg 
            20                  25                  30          


Thr Val Leu Glu Glu Ile Gly Asn Arg Val Thr Thr Arg Ala Ala Gln 
        35                  40                  45              


Val Ala Lys Lys Ala Gln Asn Thr Lys Val Pro Val Gln Pro Thr Lys 
    50                  55                  60                  


Thr Thr Asn Val Asn Lys Gln Leu Lys Pro Thr Ala Ser Val Lys Pro 
65                  70                  75                  80  


Val Gln Met Glu Lys Leu Ala Pro Lys Gly Pro Ser Pro Thr Pro Glu 
                85                  90                  95      


Asp Val Ser Met Lys Glu Glu Asn Leu Cys Gln Ala Phe Ser Asp Ala 
            100                 105                 110         


Leu Leu Cys Lys Ile Glu Asp Ile Asp Asn Glu Asp Trp Glu Asn Pro 
        115                 120                 125             


Gln Leu Cys Ser Asp Tyr Val Lys Asp Ile Tyr Gln Tyr Leu Arg Gln 
    130                 135                 140                 


Leu Glu Val Leu Gln Ser Ile Asn Pro His Phe Leu Asp Gly Arg Asp 
145                 150                 155                 160 


Ile Asn Gly Arg Met Arg Ala Ile Leu Val Asp Trp Leu Val Gln Val 
                165                 170                 175     


His Ser Lys Phe Arg Leu Leu Gln Glu Thr Leu Tyr Met Cys Val Gly 
            180                 185                 190         


Ile Met Asp Arg Phe Leu Gln Val Gln Pro Val Ser Arg Lys Lys Leu 
        195                 200                 205             


Gln Leu Val Gly Ile Thr Ala Leu Leu Leu Ala Ser Lys Tyr Glu Glu 
    210                 215                 220                 


Met Phe Ser Pro Asn Ile Glu Asp Phe Val Tyr Ile Thr Asp Asn Ala 
225                 230                 235                 240 


Tyr Thr Ser Ser Gln Ile Arg Glu Met Glu Thr Leu Ile Leu Lys Glu 
                245                 250                 255     


Leu Lys Phe Glu Leu Gly Arg Pro Leu Pro Leu His Phe Leu Arg Arg 
            260                 265                 270         


Ala Ser Lys Ala Gly Glu Val Asp Val Glu Gln His Thr Leu Ala Lys 
        275                 280                 285             


Tyr Leu Met Glu Leu Thr Leu Ile Asp Tyr Asp Met Val His Tyr His 
    290                 295                 300                 


Pro Ser Lys Val Ala Ala Ala Ala Ser Cys Leu Ser Gln Lys Val Leu 
305                 310                 315                 320 


Gly Gln Gly Lys Trp Asn Leu Lys Gln Gln Tyr Tyr Thr Gly Tyr Thr 
                325                 330                 335     


Glu Asn Glu Val Leu Glu Val Met Gln His Met Ala Lys Asn Val Val 
            340                 345                 350         


Lys Val Asn Glu Asn Leu Thr Lys Phe Ile Ala Ile Lys Asn Lys Tyr 
        355                 360                 365             


Ala Ser Ser Lys Leu Leu Lys Ile Ser Met Ile Pro Gln Leu Asn Ser 
    370                 375                 380                 


Lys Ala Val Lys Asp Leu Ala Ser Pro Leu Ile Gly Arg Ser 
385                 390                 395             


<210>  1747
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNB3__Homo_sapiens__NP_391990

<400>  1747

Met Leu Leu Pro Leu Pro Pro Gln Ser Ser Lys Pro Val Pro Lys Lys 
1               5                   10                  15      


Ser Gln Ser Ser Lys Ile Val Pro Ser His His Asp Pro Ser Glu Lys 
            20                  25                  30          


Thr Gly Glu Asn Cys Gln Thr Lys Ile Ser Pro Ser Ser Leu Gln Glu 
        35                  40                  45              


Ser Pro Ser Ser Leu Gln Gly Ala Leu Lys Lys Arg Ser Ala Phe Glu 
    50                  55                  60                  


Asp Leu Thr Asn Val Ser Phe Glu Met Thr His Glu Thr Leu Tyr Leu 
65                  70                  75                  80  


Ala Val Lys Leu Val Asp Leu Tyr Leu Met Lys Ala Val Cys Lys Lys 
                85                  90                  95      


Asp Lys Leu Gln Leu Leu Gly Ala Thr Ala Phe Met Ile Ala Ala Lys 
            100                 105                 110         


Phe Glu Glu His Asn Ser Pro Arg Val Asp Asp Phe Val Tyr Ile Cys 
        115                 120                 125             


Asp Asp Asn Tyr Gln Arg Ser Glu Val Leu Ser Met Glu Ile Asn Ile 
    130                 135                 140                 


Leu Asn Val Leu Lys Cys Asp Ile Asn Ile Pro Ile Ala Tyr His Phe 
145                 150                 155                 160 


Leu Arg Arg Tyr Ala Arg Cys Ile His Thr Asn Met Lys Thr Leu Thr 
                165                 170                 175     


Leu Ser Arg Tyr Ile Cys Glu Met Thr Leu Gln Glu Tyr His Tyr Val 
            180                 185                 190         


Gln Glu Lys Ala Ser Lys Leu Ala Ala Ala Ser Leu Leu Leu Ala Leu 
        195                 200                 205             


Tyr Met Lys Lys Leu Gly Tyr Trp Val Pro Phe Leu Glu His Tyr Ser 
    210                 215                 220                 


Gly Tyr Ser Ile Ser Glu Leu His Pro Leu Val Arg Gln Leu Asn Lys 
225                 230                 235                 240 


Leu Leu Thr Phe Ser Ser Tyr Asp Ser Leu Lys Ala Val Tyr Tyr Lys 
                245                 250                 255     


Tyr Ser His Pro Val Phe Phe Glu Val Ala Lys Ile Pro Ala Leu Asp 
            260                 265                 270         


Met Leu Lys Leu Glu Glu Ile Leu Asn Cys Asp Cys Glu Ala Gln Gly 
        275                 280                 285             


Leu Val Leu 
    290     


<210>  1748
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNC__Homo_sapiens__NP_001013417

<400>  1748

Met Ala Pro Thr Cys Val Phe Leu Ala Ser Lys Val Glu Glu Phe Gly 
1               5                   10                  15      


Val Val Ser Asn Thr Arg Leu Ile Ala Ala Ala Thr Ser Val Leu Lys 
            20                  25                  30          


Thr Arg Phe Ser Tyr Ala Phe Pro Lys Glu Phe Pro Tyr Arg Met Asn 
        35                  40                  45              


His Ile Leu Glu Cys Glu Phe Tyr Leu Leu Glu Leu Met Asp Cys Cys 
    50                  55                  60                  


Leu Ile Val Tyr His Pro Tyr Arg Pro Leu Leu Gln Tyr Val Gln Asp 
65                  70                  75                  80  


Met Gly Gln Glu Asp Met Leu Leu Pro Leu Ala Trp Arg Ile Val Asn 
                85                  90                  95      


Asp Thr Tyr Arg Thr Asp Leu Cys Leu Leu Tyr Pro Pro Phe Met Ile 
            100                 105                 110         


Ala Leu Ala Cys Leu His Val Ala Cys Val Val Gln Gln Lys Asp Ala 
        115                 120                 125             


Arg Gln Trp Phe Ala Glu Leu Ser Val Asp Met Glu Lys Ile Leu Glu 
    130                 135                 140                 


Ile Ile Arg Val Ile Leu Lys Leu Tyr Glu Gln Trp Lys Asn Phe Asp 
145                 150                 155                 160 


Glu Arg Lys Glu Met Ala Thr Ile Leu Ser Lys Met Pro Lys Pro Lys 
                165                 170                 175     


Pro Pro Pro Asn Ser Glu Gly Glu Gln Gly Pro Asn Gly Ser Gln Asn 
            180                 185                 190         


Ser Ser Tyr Ser Gln Ser 
        195             


<210>  1749
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCND1__Homo_sapiens__NP_444284

<400>  1749

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  1750
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCND2__Homo_sapiens__NP_001750

<400>  1750

Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg 
1               5                   10                  15      


Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr 
            20                  25                  30          


Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln 
        35                  40                  45              


Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu 
    50                  55                  60                  


Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala 
65                  70                  75                  80  


Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser 
                85                  90                  95      


His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu 
            100                 105                 110         


Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp 
        115                 120                 125             


Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu 
    130                 135                 140                 


Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile 
145                 150                 155                 160 


Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu 
                165                 170                 175     


Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe 
            180                 185                 190         


Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly 
        195                 200                 205             


Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr 
    210                 215                 220                 


Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val 
225                 230                 235                 240 


Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn 
                245                 250                 255     


Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu 
            260                 265                 270         


Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp 
        275                 280                 285             


Leu 
    


<210>  1751
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCND3__Homo_sapiens__NP_001129489

<400>  1751

Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys Ala 
1               5                   10                  15      


Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys Leu 
            20                  25                  30          


Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr Asp 
        35                  40                  45              


His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val Leu 
    50                  55                  60                  


Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe Leu 
65                  70                  75                  80  


Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala Leu 
                85                  90                  95      


Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp Tyr 
            100                 105                 110         


Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile Gly 
        115                 120                 125             


Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu Leu 
    130                 135                 140                 


Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu Arg 
145                 150                 155                 160 


Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg Glu 
                165                 170                 175     


Ala Ser Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly Ser 
            180                 185                 190         


Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr Ala 
        195                 200                 205             


Ile His Leu 
    210     


<210>  1752
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNDBP1__Homo_sapiens__NP_036274

<400>  1752

Met Ala Ser Ala Thr Ala Pro Ala Ala Ala Val Pro Thr Leu Ala Ser 
1               5                   10                  15      


Pro Leu Glu Gln Leu Arg His Leu Ala Glu Glu Leu Arg Leu Leu Leu 
            20                  25                  30          


Pro Arg Val Arg Val Gly Glu Ala Gln Glu Thr Thr Glu Glu Phe Asn 
        35                  40                  45              


Arg Glu Met Phe Trp Arg Arg Leu Asn Glu Ala Ala Val Thr Val Ser 
    50                  55                  60                  


Arg Glu Ala Thr Thr Leu Thr Ile Val Phe Ser Gln Leu Pro Leu Pro 
65                  70                  75                  80  


Ser Pro Gln Glu Thr Gln Lys Phe Cys Glu Gln Val His Ala Ala Ile 
                85                  90                  95      


Lys Ala Phe Ile Ala Val Tyr Tyr Leu Leu Pro Lys Asp Gln Gly Ile 
            100                 105                 110         


Thr Leu Arg Lys Leu Val Arg Gly Ala Thr Leu Asp Ile Val Asp Gly 
        115                 120                 125             


Met Ala Gln Leu Met Glu Val Leu Ser Val Thr Pro Thr Gln Ser Pro 
    130                 135                 140                 


Glu Asn Asn Asp Leu Ile Ser Tyr Asn Ser Val Trp Val Ala Cys Gln 
145                 150                 155                 160 


Gln Met Pro Gln Ile Pro Arg Asp Asn Lys Ala Ala Ala Leu Leu Met 
                165                 170                 175     


Leu Thr Lys Asn Val Asp Phe Val Lys Asp Ala His Glu Glu Met Glu 
            180                 185                 190         


Gln Ala Val Glu Glu Cys Asp Pro Tyr Ser Gly Leu Leu Asn Asp Thr 
        195                 200                 205             


Glu Glu Asn Asn Ser Asp Asn His Asn His Glu Asp Asp Val Leu Gly 
    210                 215                 220                 


Phe Pro Ser Asn Gln Asp Leu Tyr Trp Ser Glu Asp Asp Gln Glu Leu 
225                 230                 235                 240 


Ile Ile Pro Cys Leu Ala Leu Val Arg Ala Ser Lys Ala Cys Leu Lys 
                245                 250                 255     


Lys Ile Arg Met Leu Val Ala Glu Asn Gly Lys Lys Asp Gln Val Ala 
            260                 265                 270         


Gln Leu Asp Asp Ile Val Asp Ile Ser Asp Glu Ile Ser Pro Ser Val 
        275                 280                 285             


Asp Asp Leu Ala Leu Ser Ile Tyr Pro Pro Met Cys His Leu Thr Val 
    290                 295                 300                 


Arg Ile Asn Ser Ala Lys Leu Val Ser Val Leu Lys Lys Ala Leu Glu 
305                 310                 315                 320 


Ile Thr Lys Ala Ser His Val Thr Pro Gln Pro Glu Asp Ser Trp Ile 
                325                 330                 335     


Pro Leu Leu Ile Asn Ala Ile Asp His Cys Met Asn Arg Ile Lys Glu 
            340                 345                 350         


Leu Thr Gln Ser Glu Leu Glu Leu 
        355                 360 


<210>  1753
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNE1__Homo_sapiens__NP_001229

<400>  1753

Met Pro Arg Glu Arg Arg Glu Arg Asp Ala Lys Glu Arg Asp Thr Met 
1               5                   10                  15      


Lys Glu Asp Gly Gly Ala Glu Phe Ser Ala Arg Ser Arg Lys Arg Lys 
            20                  25                  30          


Ala Asn Val Thr Val Phe Leu Gln Asp Pro Asp Glu Glu Met Ala Lys 
        35                  40                  45              


Ile Asp Arg Thr Ala Arg Asp Gln Cys Gly Ser Gln Pro Trp Asp Asn 
    50                  55                  60                  


Asn Ala Val Cys Ala Asp Pro Cys Ser Leu Ile Pro Thr Pro Asp Lys 
65                  70                  75                  80  


Glu Asp Asp Asp Arg Val Tyr Pro Asn Ser Thr Cys Lys Pro Arg Ile 
                85                  90                  95      


Ile Ala Pro Ser Arg Gly Ser Pro Leu Pro Val Leu Ser Trp Ala Asn 
            100                 105                 110         


Arg Glu Glu Val Trp Lys Ile Met Leu Asn Lys Glu Lys Thr Tyr Leu 
        115                 120                 125             


Arg Asp Gln His Phe Leu Glu Gln His Pro Leu Leu Gln Pro Lys Met 
    130                 135                 140                 


Arg Ala Ile Leu Leu Asp Trp Leu Met Glu Val Cys Glu Val Tyr Lys 
145                 150                 155                 160 


Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Tyr 
                165                 170                 175     


Met Ala Thr Gln Glu Asn Val Val Lys Thr Leu Leu Gln Leu Ile Gly 
            180                 185                 190         


Ile Ser Ser Leu Phe Ile Ala Ala Lys Leu Glu Glu Ile Tyr Pro Pro 
        195                 200                 205             


Lys Leu His Gln Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Gly Asp 
    210                 215                 220                 


Glu Ile Leu Thr Met Glu Leu Met Ile Met Lys Ala Leu Lys Trp Arg 
225                 230                 235                 240 


Leu Ser Pro Leu Thr Ile Val Ser Trp Leu Asn Val Tyr Met Gln Val 
                245                 250                 255     


Ala Tyr Leu Asn Asp Leu His Glu Val Leu Leu Pro Gln Tyr Pro Gln 
            260                 265                 270         


Gln Ile Phe Ile Gln Ile Ala Glu Leu Leu Asp Leu Cys Val Leu Asp 
        275                 280                 285             


Val Asp Cys Leu Glu Phe Pro Tyr Gly Ile Leu Ala Ala Ser Ala Leu 
    290                 295                 300                 


Tyr His Phe Ser Ser Ser Glu Leu Met Gln Lys Val Ser Gly Tyr Gln 
305                 310                 315                 320 


Trp Cys Asp Ile Glu Asn Cys Val Lys Trp Met Val Pro Phe Ala Met 
                325                 330                 335     


Val Ile Arg Glu Thr Gly Ser Ser Lys Leu Lys His Phe Arg Gly Val 
            340                 345                 350         


Ala Asp Glu Asp Ala His Asn Ile Gln Thr His Arg Asp Ser Leu Asp 
        355                 360                 365             


Leu Leu Asp Lys Ala Arg Ala Lys Lys Ala Met Leu Ser Glu Gln Asn 
    370                 375                 380                 


Arg Ala Ser Pro Leu Pro Ser Gly Leu Leu Thr Pro Pro Gln Ser Gly 
385                 390                 395                 400 


Lys Lys Gln Ser Ser Gly Pro Glu Met Ala 
                405                 410 


<210>  1754
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNE2__Homo_sapiens__NP_477097

<400>  1754

Met Ser Arg Arg Ser Ser Arg Leu Gln Ala Lys Gln Gln Pro Gln Pro 
1               5                   10                  15      


Ser Gln Thr Glu Ser Pro Gln Glu Ala Gln Ile Ile Gln Ala Lys Lys 
            20                  25                  30          


Arg Lys Thr Thr Gln Asp Val Lys Lys Arg Arg Glu Glu Val Thr Lys 
        35                  40                  45              


Lys His Gln Tyr Glu Ile Arg Asn Cys Trp Pro Pro Val Leu Ser Gly 
    50                  55                  60                  


Gly Ile Ser Pro Cys Ile Ile Ile Glu Thr Pro His Lys Glu Ile Gly 
65                  70                  75                  80  


Thr Ser Asp Phe Ser Arg Phe Thr Asn Tyr Arg Phe Lys Asn Leu Phe 
                85                  90                  95      


Ile Asn Pro Ser Pro Leu Pro Asp Leu Ser Trp Gly Cys Ser Lys Glu 
            100                 105                 110         


Val Trp Leu Asn Met Leu Lys Lys Glu Ser Arg Tyr Val His Asp Lys 
        115                 120                 125             


His Phe Glu Val Leu His Ser Asp Leu Glu Pro Gln Met Arg Ser Ile 
    130                 135                 140                 


Leu Leu Asp Trp Leu Leu Glu Val Cys Glu Val Tyr Thr Leu His Arg 
145                 150                 155                 160 


Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Phe Met Leu Thr 
                165                 170                 175     


Gln Lys Asp Ile Asn Lys Asn Met Leu Gln Leu Ile Gly Ile Thr Ser 
            180                 185                 190         


Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr Ala Pro Lys Leu Gln 
        195                 200                 205             


Glu Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Glu Glu Asp Ile Leu 
    210                 215                 220                 


Arg Met Glu Leu Ile Ile Leu Lys Ala Leu Lys Trp Glu Leu Cys Pro 
225                 230                 235                 240 


Val Thr Ile Ile Ser Trp Leu Asn Leu Phe Leu Gln Val Asp Ala Leu 
                245                 250                 255     


Lys Asp Ala Pro Lys Val Leu Leu Pro Gln Tyr Ser Gln Glu Thr Phe 
            260                 265                 270         


Ile Gln Ile Ala Gln Leu Leu Asp Leu Cys Ile Leu Ala Ile Asp Ser 
        275                 280                 285             


Leu Glu Phe Gln Tyr Arg Ile Leu Thr Ala Ala Ala Leu Cys His Phe 
    290                 295                 300                 


Thr Ser Ile Glu Val Val Lys Lys Ala Ser Gly Leu Glu Trp Asp Ser 
305                 310                 315                 320 


Ile Ser Glu Cys Val Asp Trp Met Val Pro Phe Val Asn Val Val Lys 
                325                 330                 335     


Ser Thr Ser Pro Val Lys Leu Lys Thr Phe Lys Lys Ile Pro Met Glu 
            340                 345                 350         


Asp Arg His Asn Ile Gln Thr His Thr Asn Tyr Leu Ala Met Leu Glu 
        355                 360                 365             


Glu Val Asn Tyr Ile Asn Thr Phe Arg Lys Gly Gly Gln Leu Ser Pro 
    370                 375                 380                 


Val Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser Thr Glu Lys Pro 
385                 390                 395                 400 


Pro Gly Lys His 
                


<210>  1755
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNF__Homo_sapiens__NP_001752

<400>  1755

Met Gly Ser Gly Gly Val Val His Cys Arg Cys Ala Lys Cys Phe Cys 
1               5                   10                  15      


Tyr Pro Thr Lys Arg Arg Ile Arg Arg Arg Pro Arg Asn Leu Thr Ile 
            20                  25                  30          


Leu Ser Leu Pro Glu Asp Val Leu Phe His Ile Leu Lys Trp Leu Ser 
        35                  40                  45              


Val Glu Asp Ile Leu Ala Val Arg Ala Val His Ser Gln Leu Lys Asp 
    50                  55                  60                  


Leu Val Asp Asn His Ala Ser Val Trp Ala Cys Ala Ser Phe Gln Glu 
65                  70                  75                  80  


Leu Trp Pro Ser Pro Gly Asn Leu Lys Leu Phe Glu Arg Ala Ala Glu 
                85                  90                  95      


Lys Gly Asn Phe Glu Ala Ala Val Lys Leu Gly Ile Ala Tyr Leu Tyr 
            100                 105                 110         


Asn Glu Gly Leu Ser Val Ser Asp Glu Ala Arg Ala Glu Val Asn Gly 
        115                 120                 125             


Leu Lys Ala Ser Arg Phe Phe Ser Leu Ala Glu Arg Leu Asn Val Gly 
    130                 135                 140                 


Ala Ala Pro Phe Ile Trp Leu Phe Ile Arg Pro Pro Trp Ser Val Ser 
145                 150                 155                 160 


Gly Ser Cys Cys Lys Ala Val Val His Glu Ser Leu Arg Ala Glu Cys 
                165                 170                 175     


Gln Leu Gln Arg Thr His Lys Ala Ser Ile Leu His Cys Leu Gly Arg 
            180                 185                 190         


Val Leu Ser Leu Phe Glu Asp Glu Glu Lys Gln Gln Gln Ala His Asp 
        195                 200                 205             


Leu Phe Glu Glu Ala Ala His Gln Gly Cys Leu Thr Ser Ser Tyr Leu 
    210                 215                 220                 


Leu Trp Glu Ser Asp Arg Arg Thr Asp Val Ser Asp Pro Gly Arg Cys 
225                 230                 235                 240 


Leu His Ser Phe Arg Lys Leu Arg Asp Tyr Ala Ala Lys Gly Cys Trp 
                245                 250                 255     


Glu Ala Gln Leu Ser Leu Ala Lys Ala Cys Ala Asn Ala Asn Gln Leu 
            260                 265                 270         


Gly Leu Glu Val Arg Ala Ser Ser Glu Ile Val Cys Gln Leu Phe Gln 
        275                 280                 285             


Ala Ser Gln Ala Val Ser Lys Gln Gln Val Phe Ser Val Gln Lys Gly 
    290                 295                 300                 


Leu Asn Asp Thr Met Arg Tyr Ile Leu Ile Asp Trp Leu Val Glu Val 
305                 310                 315                 320 


Ala Thr Met Lys Asp Phe Thr Ser Leu Cys Leu His Leu Thr Val Glu 
                325                 330                 335     


Cys Val Asp Arg Tyr Leu Arg Arg Arg Leu Val Pro Arg Tyr Arg Leu 
            340                 345                 350         


Gln Leu Leu Gly Ile Ala Cys Met Val Ile Cys Thr Arg Phe Ile Ser 
        355                 360                 365             


Lys Glu Ile Leu Thr Ile Arg Glu Ala Val Trp Leu Thr Asp Asn Thr 
    370                 375                 380                 


Tyr Lys Tyr Glu Asp Leu Val Arg Met Met Gly Glu Ile Val Ser Ala 
385                 390                 395                 400 


Leu Glu Gly Lys Ile Arg Val Pro Thr Val Val Asp Tyr Lys Glu Val 
                405                 410                 415     


Leu Leu Thr Leu Val Pro Val Glu Leu Arg Thr Gln His Leu Cys Ser 
            420                 425                 430         


Phe Leu Cys Glu Leu Ser Leu Leu His Thr Ser Leu Ser Ala Tyr Ala 
        435                 440                 445             


Pro Ala Arg Leu Ala Ala Ala Ala Leu Leu Leu Ala Arg Leu Thr His 
    450                 455                 460                 


Gly Gln Thr Gln Pro Trp Thr Thr Gln Leu Trp Asp Leu Thr Gly Phe 
465                 470                 475                 480 


Ser Tyr Glu Asp Leu Ile Pro Cys Val Leu Ser Leu His Lys Lys Cys 
                485                 490                 495     


Phe His Asp Asp Ala Pro Lys Asp Tyr Arg Gln Val Ser Leu Thr Ala 
            500                 505                 510         


Val Lys Gln Arg Phe Glu Asp Lys Arg Tyr Gly Glu Ile Ser Gln Glu 
        515                 520                 525             


Glu Val Leu Ser Tyr Ser Gln Leu Cys Ala Ala Leu Gly Val Thr Gln 
    530                 535                 540                 


Asp Ser Pro Asp Pro Pro Thr Phe Leu Ser Thr Gly Glu Ile His Ala 
545                 550                 555                 560 


Phe Leu Ser Ser Pro Ser Gly Arg Arg Thr Lys Arg Lys Arg Glu Asn 
                565                 570                 575     


Ser Leu Gln Glu Asp Arg Gly Ser Phe Val Thr Thr Pro Thr Ala Glu 
            580                 585                 590         


Leu Ser Ser Gln Glu Glu Thr Leu Leu Gly Ser Phe Leu Asp Trp Ser 
        595                 600                 605             


Leu Asp Cys Cys Ser Gly Tyr Glu Gly Asp Gln Glu Ser Glu Gly Glu 
    610                 615                 620                 


Lys Glu Gly Asp Val Thr Ala Pro Ser Gly Ile Leu Asp Val Thr Val 
625                 630                 635                 640 


Val Tyr Leu Asn Pro Glu Gln His Cys Cys Gln Glu Ser Ser Asp Glu 
                645                 650                 655     


Glu Ala Cys Pro Glu Asp Lys Gly Pro Gln Asp Pro Gln Ala Leu Ala 
            660                 665                 670         


Leu Asp Thr Gln Ile Pro Ala Thr Pro Gly Pro Lys Pro Leu Val Arg 
        675                 680                 685             


Thr Ser Arg Glu Pro Gly Lys Asp Val Thr Thr Ser Gly Tyr Ser Ser 
    690                 695                 700                 


Val Ser Thr Ala Ser Pro Thr Ser Ser Val Asp Gly Gly Leu Gly Ala 
705                 710                 715                 720 


Leu Pro Gln Pro Thr Ser Val Leu Ser Leu Asp Ser Asp Ser His Thr 
                725                 730                 735     


Gln Pro Cys His His Gln Ala Arg Lys Ser Cys Leu Gln Cys Arg Pro 
            740                 745                 750         


Pro Ser Pro Pro Glu Ser Ser Val Pro Gln Gln Gln Val Lys Arg Ile 
        755                 760                 765             


Asn Leu Cys Ile His Ser Glu Glu Glu Asp Met Asn Leu Gly Leu Val 
    770                 775                 780                 


Arg Leu 
785     


<210>  1756
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNG1__Homo_sapiens__NP_954854

<400>  1756

Met Ile Glu Val Leu Thr Thr Thr Asp Ser Gln Lys Leu Leu His Gln 
1               5                   10                  15      


Leu Asn Ala Leu Leu Glu Gln Glu Ser Arg Cys Gln Pro Lys Val Cys 
            20                  25                  30          


Gly Leu Arg Leu Ile Glu Ser Ala His Asp Asn Gly Leu Arg Met Thr 
        35                  40                  45              


Ala Arg Leu Arg Asp Phe Glu Val Lys Asp Leu Leu Ser Leu Thr Gln 
    50                  55                  60                  


Phe Phe Gly Phe Asp Thr Glu Thr Phe Ser Leu Ala Val Asn Leu Leu 
65                  70                  75                  80  


Asp Arg Phe Leu Ser Lys Met Lys Val Gln Pro Lys His Leu Gly Cys 
                85                  90                  95      


Val Gly Leu Ser Cys Phe Tyr Leu Ala Val Lys Ser Ile Glu Glu Glu 
            100                 105                 110         


Arg Asn Val Pro Leu Ala Thr Asp Leu Ile Arg Ile Ser Gln Tyr Arg 
        115                 120                 125             


Phe Thr Val Ser Asp Leu Met Arg Met Glu Lys Ile Val Leu Glu Lys 
    130                 135                 140                 


Val Cys Trp Lys Val Lys Ala Thr Thr Ala Phe Gln Phe Leu Gln Leu 
145                 150                 155                 160 


Tyr Tyr Ser Leu Leu Gln Glu Asn Leu Pro Leu Glu Arg Arg Asn Ser 
                165                 170                 175     


Ile Asn Phe Glu Arg Leu Glu Ala Gln Leu Lys Ala Cys His Cys Arg 
            180                 185                 190         


Ile Ile Phe Ser Lys Ala Lys Pro Ser Val Leu Ala Leu Ser Ile Ile 
        195                 200                 205             


Ala Leu Glu Ile Gln Ala Gln Lys Cys Val Glu Leu Thr Glu Gly Ile 
    210                 215                 220                 


Glu Cys Leu Gln Lys His Ser Lys Ile Asn Gly Arg Asp Leu Thr Phe 
225                 230                 235                 240 


Trp Gln Glu Leu Val Ser Lys Cys Leu Thr Glu Tyr Ser Ser Asn Lys 
                245                 250                 255     


Cys Ser Lys Pro Asn Val Gln Lys Leu Lys Trp Ile Val Ser Gly Arg 
            260                 265                 270         


Thr Ala Arg Gln Leu Lys His Ser Tyr Tyr Arg Ile Thr His Leu Pro 
        275                 280                 285             


Thr Ile Pro Glu Met Val Pro 
    290                 295 


<210>  1757
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNG2__Homo_sapiens__XP_011530701

<400>  1757

Met Lys Asp Leu Gly Ala Glu His Leu Ala Gly His Glu Gly Val Gln 
1               5                   10                  15      


Leu Leu Gly Leu Leu Asn Val Tyr Leu Glu Gln Glu Glu Arg Phe Gln 
            20                  25                  30          


Pro Arg Glu Lys Gly Leu Ser Leu Ile Glu Ala Thr Pro Glu Asn Asp 
        35                  40                  45              


Asn Thr Leu Cys Pro Gly Leu Arg Asn Ala Lys Val Glu Asp Leu Arg 
    50                  55                  60                  


Ser Leu Ala Asn Phe Phe Gly Ser Cys Thr Glu Thr Phe Val Leu Ala 
65                  70                  75                  80  


Val Asn Ile Leu Asp Arg Phe Leu Ala Leu Met Lys Val Lys Pro Lys 
                85                  90                  95      


His Leu Ser Cys Ile Gly Val Cys Ser Phe Leu Leu Ala Ala Arg Ile 
            100                 105                 110         


Val Glu Glu Asp Cys Asn Ile Pro Ser Thr His Asp Val Ile Arg Ile 
        115                 120                 125             


Ser Gln Cys Lys Cys Thr Ala Ser Asp Ile Lys Arg Met Glu Lys Ile 
    130                 135                 140                 


Ile Ser Glu Lys Leu His Tyr Glu Leu Glu Ala Thr Thr Ala Leu Asn 
145                 150                 155                 160 


Phe Leu His Leu Tyr His Thr Ile Ile Leu Cys His Thr Ser Glu Arg 
                165                 170                 175     


Lys Glu Ile Leu Ser Leu Asp Lys Leu Glu Ala Gln Leu Lys Ala Cys 
            180                 185                 190         


Asn Cys Arg Leu Ile Phe Ser Lys Ala Lys Pro Ser Val Leu Ala Leu 
        195                 200                 205             


Cys Leu Leu Asn Leu Glu Val Glu Thr Leu Lys Ser Val Glu Leu Leu 
    210                 215                 220                 


Glu Ile Leu Leu Leu Val Lys Lys His Ser Lys Ile Asn Asp Thr Glu 
225                 230                 235                 240 


Phe Phe Tyr Trp Arg Glu Leu Val Ser Lys Cys Leu Ala Glu Tyr Ser 
                245                 250                 255     


Ser Pro Glu Cys Cys Lys Pro Asp Leu Lys Lys Leu Val Trp Ile Val 
            260                 265                 270         


Ser Arg Arg Thr Ala Gln Asn Leu His Asn Ser Tyr Tyr Ser Val Pro 
        275                 280                 285             


Glu Leu Pro Thr Ile Pro Glu Gly Gly Cys Phe Asp Glu Ser Glu Ser 
    290                 295                 300                 


Glu Asp Ser Cys Glu Asp Met Ser Cys Gly Glu Glu Ser Leu Ser Ser 
305                 310                 315                 320 


Ser Pro Pro Ser Asp Gln Glu Cys Thr Phe Phe Phe Asn Phe Lys Val 
                325                 330                 335     


Ala Gln Thr Leu Cys Phe Pro Ser 
            340                 


<210>  1758
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNH__Homo_sapiens__NP_001186118

<400>  1758

Met Thr Leu Cys Lys Tyr Tyr Glu Lys Arg Leu Leu Glu Phe Cys Ser 
1               5                   10                  15      


Val Phe Lys Pro Ala Met Pro Arg Ser Val Val Gly Thr Ala Cys Met 
            20                  25                  30          


Tyr Phe Lys Arg Phe Tyr Leu Asn Asn Ser Val Met Glu Tyr His Pro 
        35                  40                  45              


Arg Ile Ile Met Leu Thr Cys Ala Phe Leu Ala Cys Lys Val Asp Glu 
    50                  55                  60                  


Phe Asn Val Ser Ser Pro Gln Phe Val Gly Asn Leu Arg Glu Ser Pro 
65                  70                  75                  80  


Leu Gly Gln Glu Lys Ala Leu Glu Gln Ile Leu Glu Tyr Glu Leu Leu 
                85                  90                  95      


Leu Ile Gln Gln Leu Asn Phe His Leu Ile Val His Asn Pro Tyr Arg 
            100                 105                 110         


Pro Phe Glu Gly Phe Leu Ile Asp Leu Lys Thr Arg Tyr Pro Ile Leu 
        115                 120                 125             


Glu Asn Pro Glu Ile Leu Arg Lys Thr Ala Asp Asp Phe Leu Asn Arg 
    130                 135                 140                 


Ile Ala Leu Thr Asp Ala Tyr Leu Leu Tyr Thr Pro Ser Gln Ile Ala 
145                 150                 155                 160 


Leu Thr Ala Ile Leu Ser Ser Ala Ser Arg Ala Gly Ile Thr Met Glu 
                165                 170                 175     


Ser Tyr Leu Ser Glu Ser Leu Met Leu Lys Glu Asn Arg Thr Cys Leu 
            180                 185                 190         


Ser Gln Leu Leu Asp Ile Met Lys Ser Met Arg Asn Leu Val Lys Lys 
        195                 200                 205             


Tyr Glu Pro Pro Arg Ser Glu Glu Val Ala Val Leu Lys Gln Lys Leu 
    210                 215                 220                 


Glu Arg Cys His Ser Ala Glu Leu Ala Leu Asn Val Ile Thr Lys Lys 
225                 230                 235                 240 


Arg Lys Gly Tyr Glu Asp Asp Asp Tyr Val Ser Lys Lys Ser Lys His 
                245                 250                 255     


Glu Glu Glu Glu Trp Thr Asp Asp Asp Leu Val Glu Ser Leu 
            260                 265                 270 


<210>  1759
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNI__Homo_sapiens__NP_006826

<400>  1759

Met Lys Phe Pro Gly Pro Leu Glu Asn Gln Arg Leu Ser Phe Leu Leu 
1               5                   10                  15      


Glu Lys Ala Ile Thr Arg Glu Ala Gln Met Trp Lys Val Asn Val Arg 
            20                  25                  30          


Lys Met Pro Ser Asn Gln Asn Val Ser Pro Ser Gln Arg Asp Glu Val 
        35                  40                  45              


Ile Gln Trp Leu Ala Lys Leu Lys Tyr Gln Phe Asn Leu Tyr Pro Glu 
    50                  55                  60                  


Thr Phe Ala Leu Ala Ser Ser Leu Leu Asp Arg Phe Leu Ala Thr Val 
65                  70                  75                  80  


Lys Ala His Pro Lys Tyr Leu Ser Cys Ile Ala Ile Ser Cys Phe Phe 
                85                  90                  95      


Leu Ala Ala Lys Thr Val Glu Glu Asp Glu Arg Ile Pro Val Leu Lys 
            100                 105                 110         


Val Leu Ala Arg Asp Ser Phe Cys Gly Cys Ser Ser Ser Glu Ile Leu 
        115                 120                 125             


Arg Met Glu Arg Ile Ile Leu Asp Lys Leu Asn Trp Asp Leu His Thr 
    130                 135                 140                 


Ala Thr Pro Leu Asp Phe Leu His Ile Phe His Ala Ile Ala Val Ser 
145                 150                 155                 160 


Thr Arg Pro Gln Leu Leu Phe Ser Leu Pro Lys Leu Ser Pro Ser Gln 
                165                 170                 175     


His Leu Ala Val Leu Thr Lys Gln Leu Leu His Cys Met Ala Cys Asn 
            180                 185                 190         


Gln Leu Leu Gln Phe Arg Gly Ser Met Leu Ala Leu Ala Met Val Ser 
        195                 200                 205             


Leu Glu Met Glu Lys Leu Ile Pro Asp Trp Leu Ser Leu Thr Ile Glu 
    210                 215                 220                 


Leu Leu Gln Lys Ala Gln Met Asp Ser Ser Gln Leu Ile His Cys Arg 
225                 230                 235                 240 


Glu Leu Val Ala His His Leu Ser Thr Leu Gln Ser Ser Leu Pro Leu 
                245                 250                 255     


Asn Ser Val Tyr Val Tyr Arg Pro Leu Lys His Thr Leu Val Thr Cys 
            260                 265                 270         


Asp Lys Gly Val Phe Arg Leu His Pro Ser Ser Val Pro Gly Pro Asp 
        275                 280                 285             


Phe Ser Lys Asp Asn Ser Lys Pro Glu Val Pro Val Arg Gly Thr Ala 
    290                 295                 300                 


Ala Phe Tyr His His Leu Pro Ala Ala Ser Gly Cys Lys Gln Thr Ser 
305                 310                 315                 320 


Thr Lys Arg Lys Val Glu Glu Met Glu Val Asp Asp Phe Tyr Asp Gly 
                325                 330                 335     


Ile Lys Arg Leu Tyr Asn Glu Asp Asn Val Ser Glu Asn Val Gly Ser 
            340                 345                 350         


Val Cys Gly Thr Asp Leu Ser Arg Gln Glu Gly His Ala Ser Pro Cys 
        355                 360                 365             


Pro Pro Leu Gln Pro Val Ser Val Met 
    370                 375         


<210>  1760
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNJ__Homo_sapiens__NP_001127847

<400>  1760

Met Glu Leu Glu Gly Gln Trp Trp Arg Gly Gln Leu Ala Ala Asp Ile 
1               5                   10                  15      


His Gln Ala Leu Arg Tyr Lys Glu Leu Lys Leu Pro Ser Tyr Lys Gly 
            20                  25                  30          


Gln Ser Pro Gln Leu Ser Leu Arg Arg Tyr Phe Ala Asp Leu Ile Ala 
        35                  40                  45              


Ile Val Ser Asn Arg Phe Thr Leu Cys Pro Ser Ala Arg His Leu Ala 
    50                  55                  60                  


Val Tyr Leu Leu Asp Leu Phe Met Asp Arg Tyr Asp Ile Ser Ile Gln 
65                  70                  75                  80  


Gln Leu His Leu Val Ala Leu Ser Cys Leu Leu Leu Ala Ser Lys Phe 
                85                  90                  95      


Glu Glu Lys Glu Asp Ser Val Pro Lys Leu Glu Gln Leu Asn Ser Leu 
            100                 105                 110         


Gly Cys Met Thr Asn Met Asn Leu Val Leu Thr Lys Gln Asn Leu Leu 
        115                 120                 125             


His Met Glu Leu Leu Leu Leu Glu Thr Phe Gln Trp Asn Leu Cys Leu 
    130                 135                 140                 


Pro Thr Ala Ala His Phe Ile Glu Tyr Tyr Leu Ser Glu Ala Val His 
145                 150                 155                 160 


Glu Thr Asp Leu His Asp Gly Trp Pro Met Ile Cys Leu Glu Lys Thr 
                165                 170                 175     


Lys Leu Tyr Met Ala Lys Tyr Ala Asp Tyr Phe Leu Glu Val Ser Leu 
            180                 185                 190         


Gln Asp Tyr Ala Phe Leu Asn Tyr Ala Pro Ser Leu Val Ala Ala Ala 
        195                 200                 205             


Cys Val Ala Ser Ser Arg Ile Ile Leu Arg Leu Ser Pro Thr Trp Pro 
    210                 215                 220                 


Thr Arg Leu His Arg Leu Thr Ala Tyr Ser Trp Asp Phe Leu Val Gln 
225                 230                 235                 240 


Cys Ile Glu Arg Leu Leu Ile Ala His Asp Asn Asp Val Lys Glu Ala 
                245                 250                 255     


Asn Lys Gln Arg Gly Gln Ala Gly Pro Gln Ser Ala Gln Leu Ser Val 
            260                 265                 270         


Phe Gln Thr Ala Ser Gln Pro Ser Arg Pro Val His Phe Gln Gln Pro 
        275                 280                 285             


Gln Tyr Leu His Gln Thr His Gln Thr Ser Leu Gln Tyr Arg His Pro 
    290                 295                 300                 


Thr Ser Glu Gln Pro Ser Cys Gln Gln Ile Val Ser Thr Thr His Thr 
305                 310                 315                 320 


Ser Ser Tyr Thr Leu Gln Thr Cys Pro Ala Gly Phe Gln Thr Ser Val 
                325                 330                 335     


Gln Gly Leu Gly His Met Gln Thr Gly Val Gly Met Ser Leu Ala Ile 
            340                 345                 350         


Pro Val Glu Val Lys Pro Cys Leu Ser Val Ser Tyr Asn Arg Ser Tyr 
        355                 360                 365             


Gln Ile Asn Glu His Tyr Pro Cys Ile Thr Pro Cys Phe Glu Arg 
    370                 375                 380             


<210>  1761
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNJL__Homo_sapiens__NP_078841

<400>  1761

Met Met Asp Glu Pro Trp Trp Glu Gly Arg Val Ala Ser Asp Val His 
1               5                   10                  15      


Cys Thr Leu Arg Glu Lys Glu Leu Lys Leu Pro Thr Phe Arg Ala His 
            20                  25                  30          


Ser Pro Leu Leu Lys Ser Arg Arg Phe Phe Val Asp Ile Leu Thr Leu 
        35                  40                  45              


Leu Ser Ser His Cys Gln Leu Cys Pro Ala Ala Arg His Leu Ala Val 
    50                  55                  60                  


Tyr Leu Leu Asp His Phe Met Asp Arg Tyr Asn Val Thr Thr Ser Lys 
65                  70                  75                  80  


Gln Leu Tyr Thr Val Ala Val Ser Cys Leu Leu Leu Ala Asn Gly Val 
                85                  90                  95      


Ser Leu Leu Ser Pro Arg Leu Lys Cys Ser Gly Met Ile Ser Ala His 
            100                 105                 110         


Cys Asn Leu His Leu Pro Gly Ser Ser Asn Ser Pro Ala Ser Ala Pro 
        115                 120                 125             


His Pro Pro Pro Thr Pro Pro Gln Val Ala Glu Thr Thr Gly Lys Phe 
    130                 135                 140                 


Glu Asp Arg Glu Asp His Val Pro Lys Leu Glu Gln Ile Asn Ser Thr 
145                 150                 155                 160 


Arg Ile Leu Ser Ser Gln Asn Phe Thr Leu Thr Lys Lys Glu Leu Leu 
                165                 170                 175     


Ser Thr Glu Leu Leu Leu Leu Glu Ala Phe Ser Trp Asn Leu Cys Leu 
            180                 185                 190         


Pro Thr Pro Ala His Phe Leu Asp Tyr Tyr Leu Leu Ala Ser Val Ser 
        195                 200                 205             


Gln Lys Asp His His Cys His Thr Trp Pro Thr Thr Cys Pro Arg Lys 
    210                 215                 220                 


Thr Lys Glu Cys Leu Lys Glu Tyr Ala His Tyr Phe Leu Glu Val Thr 
225                 230                 235                 240 


Leu Gln Asp His Ile Phe Tyr Lys Phe Gln Pro Ser Val Val Ala Ala 
                245                 250                 255     


Ala Cys Val Gly Ala Ser Arg Ile Cys Leu Gln Leu Ser Pro Tyr Trp 
            260                 265                 270         


Thr Arg Asp Leu Gln Arg Ile Ser Ser Tyr Ser Leu Glu His Leu Ser 
        275                 280                 285             


Thr Cys Ile Glu Ile Leu Leu Val Val Tyr Asp Asn Val Leu Lys Asp 
    290                 295                 300                 


Ala Val Ala Val Lys Ser Gln Ala Leu Ala Met Val Pro Gly Thr Pro 
305                 310                 315                 320 


Pro Thr Pro Thr Gln Val Leu Phe Gln Pro Pro Ala Tyr Pro Ala Leu 
                325                 330                 335     


Gly Gln Pro Ala Thr Thr Leu Ala Gln Phe Gln Thr Pro Val Gln Asp 
            340                 345                 350         


Leu Cys Leu Ala Tyr Arg Asp Ser Leu Gln Ala His Arg Ser Gly Ser 
        355                 360                 365             


Leu Leu Ser Gly Ser Thr Gly Ser Ser Leu His Thr Pro Tyr Gln Pro 
    370                 375                 380                 


Leu Gln Pro Leu Asp Met Cys Pro Val Pro Val Pro Ala Ser Leu Ser 
385                 390                 395                 400 


Met His Met Ala Ile Ala Ala Glu Pro Arg His Cys Leu Ala Thr Thr 
                405                 410                 415     


Tyr Gly Ser Ser Tyr Phe Ser Gly Ser His Met Phe Pro Thr Gly Cys 
            420                 425                 430         


Phe Asp Arg 
        435 


<210>  1762
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNK__Homo_sapiens__XP_011535577

<400>  1762

Met Lys Glu Asn Lys Glu Asn Ser Ser Pro Ser Val Thr Ser Ala Asn 
1               5                   10                  15      


Leu Asp His Thr Lys Pro Cys Trp Tyr Trp Asp Lys Lys Asp Leu Ala 
            20                  25                  30          


His Thr Pro Ser Gln Leu Glu Gly Leu Asp Pro Ala Thr Glu Ala Arg 
        35                  40                  45              


Tyr Arg Arg Glu Gly Ala Arg Phe Ile Phe Asp Val Gly Thr Arg Leu 
    50                  55                  60                  


Gly Leu His Tyr Asp Thr Leu Ala Thr Gly Ile Ile Tyr Phe His Arg 
65                  70                  75                  80  


Phe Tyr Met Phe His Ser Phe Lys Gln Phe Pro Arg Tyr Val Thr Gly 
                85                  90                  95      


Ala Cys Cys Leu Phe Leu Ala Gly Lys Val Glu Glu Thr Pro Lys Lys 
            100                 105                 110         


Cys Lys Asp Ile Ile Lys Thr Ala Arg Ser Leu Leu Asn Asp Val Gln 
        115                 120                 125             


Phe Gly Gln Phe Gly Asp Asp Pro Lys Glu Glu Val Met Val Leu Glu 
    130                 135                 140                 


Arg Ile Leu Leu Gln Thr Ile Lys Phe Asp Leu Gln Val Glu His Pro 
145                 150                 155                 160 


Tyr Gln Phe Leu Leu Lys Tyr Ala Lys Gln Leu Lys Gly Asp Lys Asn 
                165                 170                 175     


Lys Ile Gln Lys Leu Val Gln Met Ala Trp Thr Phe Val Asn Asp Ser 
            180                 185                 190         


Leu Cys Thr Thr Leu Ser Leu Gln Trp Glu Pro Glu Ile Ile Ala Val 
        195                 200                 205             


Ala Val Met Tyr Leu Ala Gly Arg Leu Cys Lys Phe Glu Ile Gln Glu 
    210                 215                 220                 


Trp Thr Ser Lys Pro Met Tyr Arg Arg Trp Trp Glu Gln Phe Val Gln 
225                 230                 235                 240 


Asp Val Pro Val Asp Val Leu Glu Asp Ile Cys His Gln Ile Leu Asp 
                245                 250                 255     


Leu Tyr Ser Gln Gly Lys Gln Gln Met Pro His His Thr Pro His Gln 
            260                 265                 270         


Leu Gln Gln Pro Pro Ser Leu Gln Pro Thr Pro Gln Val Pro Gln Val 
        275                 280                 285             


Gln Gln Ser Gln Pro Ser Gln Ser Ser Glu Pro Ser Gln Pro Gln Gln 
    290                 295                 300                 


Lys Asp Pro Gln Gln Pro Ala Gln Gln Gln Gln Pro Ala Gln Gln Pro 
305                 310                 315                 320 


Lys Lys Pro Ser Pro Gln Pro Ser Ser Pro Arg Gln Val Lys Arg Ala 
                325                 330                 335     


Val Val Val Ser Pro Lys Glu Glu Asn Lys Ala Ala Glu Pro Pro Pro 
            340                 345                 350         


Pro Lys Ile Pro Lys Ile Glu Thr Thr His Pro Pro Leu Pro Pro Ala 
        355                 360                 365             


His Pro Pro Pro Asp Arg Lys Pro Pro Leu Ala Ala Ala Leu Gly Glu 
    370                 375                 380                 


Ala Glu Pro Pro Gly Pro Val Asp Ala Thr Asp Leu Pro Lys Val Gln 
385                 390                 395                 400 


Ile Pro Pro Pro Ala His Pro Ala Pro Val His Gln Pro Pro Pro Leu 
                405                 410                 415     


Pro His Arg Pro Pro Pro Pro Pro Pro Ser Ser Tyr Met Thr Gly Met 
            420                 425                 430         


Ser Thr Thr Ser Ser Tyr Met Ser Gly Glu Gly Tyr Gln Ser Leu Gln 
        435                 440                 445             


Ser Met Met Lys Thr Glu Gly Pro Ser Tyr Gly Ala Leu Pro Pro Ala 
    450                 455                 460                 


Tyr Gly Pro Pro Ala His Leu Pro Tyr His Pro His Val Tyr Pro Pro 
465                 470                 475                 480 


Asn Pro Pro Pro Pro Pro Val Pro Pro Pro Pro Ala Ser Phe Pro Pro 
                485                 490                 495     


Pro Ala Ile Pro Pro Pro Thr Pro Gly Tyr Pro Pro Pro Pro Pro Thr 
            500                 505                 510         


Tyr Asn Pro Asn Phe Pro Pro Pro Pro Pro Arg Leu Pro Pro Thr His 
        515                 520                 525             


Ala Val Pro Pro His Pro Pro Pro Gly Leu Gly Leu Pro Pro Ala Ser 
    530                 535                 540                 


Tyr Pro Pro Pro Ala Val Pro Pro Gly Gly Gln Pro Pro Val Pro Pro 
545                 550                 555                 560 


Pro Ile Pro Pro Pro Gly Met Pro Pro Val Gly Gly Leu Gly Arg Ala 
                565                 570                 575     


Ala Trp Met Arg 
            580 


<210>  1763
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNL1__Homo_sapiens__NP_064703

<400>  1763

Met Ala Ser Gly Pro His Ser Thr Ala Thr Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ser Ala Ala Pro Ser Ala Gly Gly Ser Ser Ser Gly Thr Thr Thr Thr 
            20                  25                  30          


Thr Thr Thr Thr Thr Gly Gly Ile Leu Ile Gly Asp Arg Leu Tyr Ser 
        35                  40                  45              


Glu Val Ser Leu Thr Ile Asp His Ser Leu Ile Pro Glu Glu Arg Leu 
    50                  55                  60                  


Ser Pro Thr Pro Ser Met Gln Asp Gly Leu Asp Leu Pro Ser Glu Thr 
65                  70                  75                  80  


Asp Leu Arg Ile Leu Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu 
                85                  90                  95      


Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe His 
            100                 105                 110         


Arg Phe Phe Tyr Ser Lys Ser Phe Val Lys His Ser Phe Glu Ile Val 
        115                 120                 125             


Ala Met Ala Cys Ile Asn Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg 
    130                 135                 140                 


Arg Ile Arg Asp Val Ile Asn Val Phe His His Leu Arg Gln Leu Arg 
145                 150                 155                 160 


Gly Lys Arg Thr Pro Ser Pro Leu Ile Leu Asp Gln Asn Tyr Ile Asn 
                165                 170                 175     


Thr Lys Asn Gln Val Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu 
            180                 185                 190         


Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr 
        195                 200                 205             


Leu Gln Val Leu Glu Cys Glu Arg Asn Gln Thr Leu Val Gln Thr Ala 
    210                 215                 220                 


Trp Asn Tyr Met Asn Asp Ser Leu Arg Thr Asn Val Phe Val Arg Phe 
225                 230                 235                 240 


Gln Pro Glu Thr Ile Ala Cys Ala Cys Ile Tyr Leu Ala Ala Arg Ala 
                245                 250                 255     


Leu Gln Ile Pro Leu Pro Thr Arg Pro His Trp Phe Leu Leu Phe Gly 
            260                 265                 270         


Thr Thr Glu Glu Glu Ile Gln Glu Ile Cys Ile Glu Thr Leu Arg Leu 
        275                 280                 285             


Tyr Thr Arg Lys Lys Pro Asn Tyr Glu Leu Leu Glu Lys Glu Val Glu 
    290                 295                 300                 


Lys Arg Lys Val Ala Leu Gln Glu Ala Lys Leu Lys Ala Lys Gly Leu 
305                 310                 315                 320 


Asn Pro Asp Gly Thr Pro Ala Leu Ser Thr Leu Gly Gly Phe Ser Pro 
                325                 330                 335     


Ala Ser Lys Pro Ser Ser Pro Arg Glu Val Lys Ala Glu Glu Lys Ser 
            340                 345                 350         


Pro Ile Ser Ile Asn Val Lys Thr Val Lys Lys Glu Pro Glu Asp Arg 
        355                 360                 365             


Gln Gln Ala Ser Lys Ser Pro Tyr Asn Gly Val Arg Lys Asp Ser Lys 
    370                 375                 380                 


Arg Ser Arg Asn Ser Arg Ser Ala Ser Arg Ser Arg Ser Arg Thr Arg 
385                 390                 395                 400 


Ser Arg Ser Arg Ser His Thr Pro Arg Arg His Tyr Asn Asn Arg Arg 
                405                 410                 415     


Ser Arg Ser Gly Thr Tyr Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser 
            420                 425                 430         


His Ser Glu Ser Pro Arg Arg His His Asn His Gly Ser Pro His Leu 
        435                 440                 445             


Lys Ala Lys His Thr Arg Asp Asp Leu Lys Ser Ser Asn Arg His Gly 
    450                 455                 460                 


His Lys Arg Lys Lys Ser Arg Ser Arg Ser Gln Ser Lys Ser Arg Asp 
465                 470                 475                 480 


His Ser Asp Ala Ala Lys Lys His Arg His Glu Arg Gly His His Arg 
                485                 490                 495     


Asp Arg Arg Glu Arg Ser Arg Ser Phe Glu Arg Ser His Lys Ser Lys 
            500                 505                 510         


His His Gly Gly Ser Arg Ser Gly His Gly Arg His Arg Arg 
        515                 520                 525     


<210>  1764
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNL2__Homo_sapiens__XP_011540521

<400>  1764

Met Gly Gln Leu Ala Ala Ala Leu Met Ser Pro Arg Arg Gly Leu Pro 
1               5                   10                  15      


Leu Gly Ala Glu Ser Pro Ser Ala Arg Cys Ser His Ala Ser Asn Leu 
            20                  25                  30          


His Pro Arg Gly Phe Ser Leu Phe Gln Val Asp Ser Phe Lys Glu Ala 
        35                  40                  45              


Ala Ala Arg Ser Ala Glu Lys Gly Pro Ala Ala Ser Ala Leu Glu Glu 
    50                  55                  60                  


Glu Glu Glu Glu Pro Lys Arg Met Ala Cys Leu Pro Ala Ala Thr Pro 
65                  70                  75                  80  


Ala Leu Cys Ser Ala Ser Ser Phe Glu Asn Tyr Met Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Asp Val Phe Val Arg Phe Gln Pro Glu Ser Ile Ala Cys Ala 
            100                 105                 110         


Cys Ile Tyr Leu Ala Ala Arg Thr Leu Glu Ile Pro Leu Pro Asn Arg 
        115                 120                 125             


Pro His Trp Phe Leu Leu Phe Gly Ala Thr Glu Glu Glu Ile Gln Glu 
    130                 135                 140                 


Ile Cys Leu Lys Ile Leu Gln Leu Tyr Ala Arg Lys Lys Val Asp Leu 
145                 150                 155                 160 


Thr His Leu Glu Gly Glu Val Glu Lys Arg Lys His Ala Ile Glu Glu 
                165                 170                 175     


Ala Lys Ala Gln Ala Arg Gly Leu Leu Pro Gly Gly Thr Gln Val Leu 
            180                 185                 190         


Asp Gly Thr Ser Gly Phe Ser Pro Ala Pro Lys Leu Val Glu Ser Pro 
        195                 200                 205             


Lys Glu Gly Lys Gly Ser Lys Pro Ser Pro Leu Ser Val Lys Asn Thr 
    210                 215                 220                 


Lys Arg Arg Leu Glu Gly Ala Lys Lys Ala Lys Ala Asp Ser Pro Val 
225                 230                 235                 240 


Asn Gly Leu Pro Lys Gly Arg Glu Ser Arg Ser Arg Ser Arg Ser Arg 
                245                 250                 255     


Glu Gln Ser Tyr Ser Arg Ser Pro Ser Arg Ser Ala Ser Pro Lys Arg 
            260                 265                 270         


Arg Lys Ser Asp Ser Gly Ser Thr Ser Gly Gly Ser Lys Ser Gln Ser 
        275                 280                 285             


Arg Ser Arg Ser Arg Ser Asp Ser Pro Pro Arg Gln Ala Pro Arg Ser 
    290                 295                 300                 


Ala Pro Tyr Lys Gly Ser Glu Ile Arg Gly Ser Arg Lys Ser Lys Asp 
305                 310                 315                 320 


Cys Lys Tyr Pro Gln Lys Pro His Lys Ser Arg Ser Arg Ser Ser Ser 
                325                 330                 335     


Arg Ser Arg Ser Arg Ser Arg Glu Arg Ala Asp Asn Pro Gly Lys Tyr 
            340                 345                 350         


Lys Lys Lys Ser His Tyr Tyr Arg Asp Gln Arg Arg Glu Arg Ser Arg 
        355                 360                 365             


Ser Tyr Glu Arg Thr Gly Arg Arg Tyr Glu Arg Asp His Pro Gly His 
    370                 375                 380                 


Ser Arg His Arg Arg 
385                 


<210>  1765
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNO__Homo_sapiens__NP_066970

<400>  1765

Met Val Thr Pro Cys Pro Thr Ser Pro Ser Ser Pro Ala Ala Arg Ala 
1               5                   10                  15      


Gly Arg Arg Asp Asn Asp Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Arg Leu Arg Arg Lys Gln Pro Leu His Pro Leu Asn Pro 
        35                  40                  45              


Cys Pro Leu Pro Gly Asp Ser Gly Ile Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Gly Ser Asp Gly Ala Glu Ser Pro Ser Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Ser Pro Leu Pro Gly Pro Ala Gln Pro Val Ala Gln Leu Asp Leu Gln 
                85                  90                  95      


Thr Phe Arg Asp Tyr Gly Gln Ser Cys Tyr Ala Phe Arg Lys Ala Gln 
            100                 105                 110         


Glu Ser His Phe His Pro Arg Glu Ala Leu Ala Arg Gln Pro Gln Val 
        115                 120                 125             


Thr Ala Glu Ser Arg Cys Lys Leu Leu Ser Trp Leu Ile Pro Val His 
    130                 135                 140                 


Arg Gln Phe Gly Leu Ser Phe Glu Ser Leu Cys Leu Thr Val Asn Thr 
145                 150                 155                 160 


Leu Asp Arg Phe Leu Thr Thr Thr Pro Val Ala Ala Asp Cys Phe Gln 
                165                 170                 175     


Leu Leu Gly Val Thr Ser Leu Leu Ile Ala Cys Lys Gln Val Glu Val 
            180                 185                 190         


His Pro Pro Arg Val Lys Gln Leu Leu Ala Leu Cys Cys Gly Ala Phe 
        195                 200                 205             


Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His Lys Leu 
    210                 215                 220                 


His Phe Thr Leu Gly Ala Pro Thr Ile Ser Phe Phe Leu Glu His Phe 
225                 230                 235                 240 


Thr His Ala Arg Val Glu Ala Gly Gln Ala Glu Ala Ser Glu Ala Leu 
                245                 250                 255     


Glu Ala Gln Ala Leu Ala Arg Gly Val Ala Glu Leu Ser Leu Ala Asp 
            260                 265                 270         


Tyr Ala Phe Thr Ser Tyr Ser Pro Ser Leu Leu Ala Ile Cys Cys Leu 
        275                 280                 285             


Ala Leu Ala Asp Arg Met Leu Arg Val Ser Arg Pro Val Asp Leu Arg 
    290                 295                 300                 


Leu Gly Asp His Pro Glu Ala Ala Leu Glu Asp Cys Met Gly Lys Leu 
305                 310                 315                 320 


Gln Leu Leu Val Ala Ile Asn Ser Thr Ser Leu Thr His Met Leu Pro 
                325                 330                 335     


Val Gln Ile Cys Glu Lys Cys Ser Leu Pro Pro Ser Ser Lys 
            340                 345                 350 


<210>  1766
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNT1__Homo_sapiens__NP_001231

<400>  1766

Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg 
1               5                   10                  15      


Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp 
            20                  25                  30          


Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met 
        35                  40                  45              


Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val 
    50                  55                  60                  


Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly 
65                  70                  75                  80  


Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu 
                85                  90                  95      


Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu 
            100                 105                 110         


His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln 
        115                 120                 125             


Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu 
    130                 135                 140                 


Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys 
145                 150                 155                 160 


Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe 
                165                 170                 175     


Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr 
            180                 185                 190         


Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser 
        195                 200                 205             


Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr 
    210                 215                 220                 


Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu 
225                 230                 235                 240 


Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp 
                245                 250                 255     


Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg 
            260                 265                 270         


Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser 
        275                 280                 285             


Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr 
    290                 295                 300                 


Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser 
305                 310                 315                 320 


Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser 
                325                 330                 335     


Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser 
            340                 345                 350         


Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly 
        355                 360                 365             


Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser 
    370                 375                 380                 


Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu 
385                 390                 395                 400 


Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser 
                405                 410                 415     


Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His 
            420                 425                 430         


Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu 
        435                 440                 445             


Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile 
    450                 455                 460                 


Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile 
465                 470                 475                 480 


Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val 
                485                 490                 495     


Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr 
            500                 505                 510         


His Pro Ser Asn His His His His His Asn His His Ser His Lys His 
        515                 520                 525             


Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp 
    530                 535                 540                 


Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser 
545                 550                 555                 560 


Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro 
                565                 570                 575     


Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala 
            580                 585                 590         


Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro 
        595                 600                 605             


Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser 
    610                 615                 620                 


Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp 
625                 630                 635                 640 


Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp 
                645                 650                 655     


Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly 
            660                 665                 670         


Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser 
        675                 680                 685             


Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn 
    690                 695                 700                 


Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro 
705                 710                 715                 720 


Leu Pro Pro Leu Pro Lys 
                725     


<210>  1767
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCNY__Homo_sapiens__NP_001269781

<400>  1767

Met Gly Asn Thr Thr Ser Cys Cys Val Ser Ser Ser Pro Lys Leu Arg 
1               5                   10                  15      


Arg Asn Ala His Ser Arg Leu Glu Ser Tyr Arg Pro Asp Thr Asp Leu 
            20                  25                  30          


Ser Arg Glu Asp Thr Gly Cys Asn Leu Gln His Ile Ser Asp Arg Glu 
        35                  40                  45              


Asn Ile Asp Val Arg Glu Lys Arg Lys Ser Leu Phe Ile Asn His His 
    50                  55                  60                  


Pro Pro Gly Gln Ile Ala Arg Lys Tyr Ser Ser Cys Ser Thr Ile Phe 
65                  70                  75                  80  


Leu Asp Asp Ser Thr Val Ser Gln Pro Asn Leu Lys Tyr Thr Ile Lys 
                85                  90                  95      


Cys Val Ala Leu Ala Ile Tyr Tyr His Ile Lys Asn Arg Asp Pro Asp 
            100                 105                 110         


Gly Arg Met Leu Leu Asp Ile Phe Asp Glu Asn Leu His Pro Leu Ser 
        115                 120                 125             


Lys Ser Glu Val Pro Pro Asp Tyr Asp Lys His Asn Pro Glu Gln Lys 
    130                 135                 140                 


Gln Ile Tyr Arg Phe Val Arg Thr Leu Phe Ser Ala Ala Gln Leu Thr 
145                 150                 155                 160 


Ala Glu Cys Ala Ile Val Thr Leu Val Tyr Leu Glu Arg Leu Leu Thr 
                165                 170                 175     


Tyr Ala Glu Ile Asp Ile Cys Pro Ala Asn Trp Lys Arg Ile Val Leu 
            180                 185                 190         


Gly Ala Ile Leu Leu Ala Ser Lys Val Trp Asp Asp Gln Ala Val Trp 
        195                 200                 205             


Asn Val Asp Tyr Cys Gln Ile Leu Lys Asp Ile Thr Val Glu Asp Met 
    210                 215                 220                 


Asn Glu Leu Glu Arg Gln Phe Leu Glu Leu Leu Gln Phe Asn Ile Asn 
225                 230                 235                 240 


Val Pro Ser Ser Val Tyr Ala Lys Tyr Tyr Phe Asp Leu Arg Ser Leu 
                245                 250                 255     


Ala Glu Ala Asn Asn Leu Ser Phe Pro Leu Glu Pro Leu Ser Arg Glu 
            260                 265                 270         


Arg Ala His Lys Leu Glu Ala Ile Ser Arg Leu Cys Glu Asp Lys Tyr 
        275                 280                 285             


Lys Asp Leu Arg Arg Ser Ala Arg Lys Arg Ser Ala Ser Ala Asp Asn 
    290                 295                 300                 


Leu Thr Leu Pro Arg Trp Ser Pro Ala Ile Ile Ser 
305                 310                 315     


<210>  1768
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCP110__Homo_sapiens__NP_055526

<400>  1768

Met Glu Glu Tyr Glu Lys Phe Cys Glu Lys Ser Leu Ala Arg Ile Gln 
1               5                   10                  15      


Glu Ala Ser Leu Ser Thr Glu Ser Phe Leu Pro Ala Gln Ser Glu Ser 
            20                  25                  30          


Ile Ser Leu Ile Arg Phe His Gly Val Ala Ile Leu Ser Pro Leu Leu 
        35                  40                  45              


Asn Ile Glu Lys Arg Lys Glu Met Gln Gln Glu Lys Gln Lys Ala Leu 
    50                  55                  60                  


Asp Val Glu Ala Arg Lys Gln Val Asn Arg Lys Lys Ala Leu Leu Thr 
65                  70                  75                  80  


Arg Val Gln Glu Ile Leu Asp Asn Val Gln Val Arg Lys Ala Pro Asn 
                85                  90                  95      


Ala Ser Asp Phe Asp Gln Trp Glu Met Glu Thr Val Tyr Ser Asn Ser 
            100                 105                 110         


Glu Val Arg Asn Leu Asn Val Pro Ala Thr Phe Pro Asn Ser Phe Pro 
        115                 120                 125             


Ser His Thr Glu His Ser Thr Ala Ala Lys Leu Asp Lys Ile Ala Gly 
    130                 135                 140                 


Ile Leu Pro Leu Asp Asn Glu Asp Gln Cys Lys Thr Asp Gly Ile Asp 
145                 150                 155                 160 


Leu Ala Arg Asp Ser Glu Gly Phe Asn Ser Pro Lys Gln Cys Asp Ser 
                165                 170                 175     


Ser Asn Ile Ser His Val Glu Asn Glu Ala Phe Pro Lys Thr Ser Ser 
            180                 185                 190         


Ala Thr Pro Gln Glu Thr Leu Ile Ser Asp Gly Pro Phe Ser Val Asn 
        195                 200                 205             


Glu Gln Gln Asp Leu Pro Leu Leu Ala Glu Val Ile Pro Asp Pro Tyr 
    210                 215                 220                 


Val Met Ser Leu Gln Asn Leu Met Lys Lys Ser Lys Glu Tyr Ile Glu 
225                 230                 235                 240 


Arg Glu Gln Ser Arg Arg Ser Leu Arg Gly Ser Met Asn Arg Ile Val 
                245                 250                 255     


Asn Glu Ser His Leu Asp Lys Glu His Asp Ala Val Glu Val Ala Asp 
            260                 265                 270         


Cys Val Lys Glu Lys Gly Gln Leu Thr Gly Lys His Cys Val Ser Val 
        275                 280                 285             


Ile Pro Asp Lys Pro Ser Leu Asn Lys Ser Asn Val Leu Leu Gln Gly 
    290                 295                 300                 


Ala Ser Thr Gln Ala Ser Ser Met Ser Met Pro Val Leu Ala Ser Phe 
305                 310                 315                 320 


Ser Lys Val Asp Ile Pro Ile Arg Thr Gly His Pro Thr Val Leu Glu 
                325                 330                 335     


Ser Asn Ser Asp Phe Lys Val Ile Pro Thr Phe Val Thr Glu Asn Asn 
            340                 345                 350         


Val Ile Lys Ser Leu Thr Gly Ser Tyr Ala Lys Leu Pro Ser Pro Glu 
        355                 360                 365             


Pro Ser Met Ser Pro Lys Met His Arg Arg Arg Ser Arg Thr Ser Ser 
    370                 375                 380                 


Ala Cys His Ile Leu Ile Asn Asn Pro Ile Asn Ala Cys Glu Leu Ser 
385                 390                 395                 400 


Pro Lys Gly Lys Glu Gln Ala Met Asp Leu Ile Ile Gln Asp Thr Asp 
                405                 410                 415     


Glu Asn Thr Asn Val Pro Glu Ile Met Pro Lys Leu Pro Thr Asp Leu 
            420                 425                 430         


Ala Gly Val Cys Ser Ser Lys Val Tyr Val Gly Lys Asn Thr Ser Glu 
        435                 440                 445             


Val Lys Glu Asp Val Val Leu Gly Lys Ser Asn Gln Val Cys Gln Ser 
    450                 455                 460                 


Ser Gly Asn His Leu Glu Asn Lys Val Thr His Gly Leu Val Thr Val 
465                 470                 475                 480 


Glu Gly Gln Leu Thr Ser Asp Glu Arg Gly Ala His Ile Met Asn Ser 
                485                 490                 495     


Thr Cys Ala Ala Met Pro Lys Leu His Glu Pro Tyr Ala Ser Ser Gln 
            500                 505                 510         


Cys Ile Ala Ser Pro Asn Phe Gly Thr Val Ser Gly Leu Lys Pro Ala 
        515                 520                 525             


Ser Met Leu Glu Lys Asn Cys Ser Leu Gln Thr Glu Leu Asn Lys Ser 
    530                 535                 540                 


Tyr Asp Val Lys Asn Pro Ser Pro Leu Leu Met Gln Asn Gln Asn Thr 
545                 550                 555                 560 


Arg Gln Gln Met Asp Thr Pro Met Val Ser Cys Gly Asn Glu Gln Phe 
                565                 570                 575     


Leu Asp Asn Ser Phe Glu Lys Val Lys Arg Arg Leu Asp Leu Asp Ile 
            580                 585                 590         


Asp Gly Leu Gln Lys Glu Asn Cys Pro Tyr Val Ile Thr Ser Gly Ile 
        595                 600                 605             


Thr Glu Gln Glu Arg Gln His Leu Pro Glu Lys Arg Tyr Pro Lys Gly 
    610                 615                 620                 


Ser Gly Phe Val Asn Lys Asn Lys Met Leu Gly Thr Ser Ser Lys Glu 
625                 630                 635                 640 


Ser Glu Glu Leu Leu Lys Ser Lys Met Leu Ala Phe Glu Glu Met Arg 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln His Ala Gln Gln Leu Ser Leu Leu Ile Ala 
            660                 665                 670         


Glu Gln Glu Arg Glu Gln Glu Arg Leu Gln Lys Glu Ile Glu Glu Gln 
        675                 680                 685             


Glu Lys Met Leu Lys Glu Lys Lys Ala Met Thr Ala Glu Ala Ser Glu 
    690                 695                 700                 


Leu Asp Ile Asn Asn Ala Val Glu Leu Glu Trp Arg Lys Ile Ser Asp 
705                 710                 715                 720 


Ser Ser Leu Leu Glu Thr Met Leu Ser Gln Ala Asp Ser Leu His Thr 
                725                 730                 735     


Ser Asn Ser Asn Ser Ser Gly Phe Thr Asn Ser Ala Met Gln Tyr Ser 
            740                 745                 750         


Phe Val Ser Ala Asn Glu Ala Pro Phe Tyr Leu Trp Gly Ser Ser Thr 
        755                 760                 765             


Ser Gly Leu Thr Lys Leu Ser Val Thr Arg Pro Phe Gly Arg Ala Lys 
    770                 775                 780                 


Thr Arg Trp Ser Gln Val Phe Ser Leu Glu Ile Gln Ala Lys Phe Asn 
785                 790                 795                 800 


Lys Ile Thr Ala Val Ala Lys Gly Phe Leu Thr Arg Arg Leu Met Gln 
                805                 810                 815     


Thr Asp Lys Leu Lys Gln Leu Arg Gln Thr Val Lys Asp Thr Met Glu 
            820                 825                 830         


Phe Ile Arg Ser Phe Gln Ser Glu Ala Pro Leu Lys Arg Gly Ile Val 
        835                 840                 845             


Ser Ala Gln Asp Ala Ser Leu Gln Glu Arg Val Leu Ala Gln Leu Arg 
    850                 855                 860                 


Ala Ala Leu Tyr Gly Ile His Asp Ile Phe Phe Val Met Asp Ala Ala 
865                 870                 875                 880 


Glu Arg Met Ser Ile Leu His His Asp Arg Glu Val Arg Lys Glu Lys 
                885                 890                 895     


Met Leu Arg Gln Met Asp Lys Met Lys Ser Pro Arg Val Ala Leu Ser 
            900                 905                 910         


Ala Ala Thr Gln Lys Ser Leu Asp Arg Lys Lys Tyr Met Lys Ala Ala 
        915                 920                 925             


Glu Met Gly Met Pro Asn Lys Lys Phe Leu Val Lys Gln Asn Pro Ser 
    930                 935                 940                 


Glu Thr Arg Val Leu Gln Pro Asn Gln Gly Gln Asn Ala Pro Val His 
945                 950                 955                 960 


Arg Leu Leu Ser Arg Gln Gly Ser Ile Cys Arg Lys Asn Pro Lys Lys 
                965                 970                 975     


Ala Ala Lys Cys Cys Asp Asn Leu Arg Arg Gln His Ser Leu Gly 
            980                 985                 990     


<210>  1769
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR10__Homo_sapiens__NP_057686

<400>  1769

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  1770
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR1__Homo_sapiens__NP_001286

<400>  1770

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  1771
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR2__Homo_sapiens__NP_001116513

<400>  1771

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  1772
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3__Homo_sapiens__NP_001158152

<400>  1772

Met Pro Phe Gly Ile Arg Met Leu Leu Arg Ala His Lys Pro Gly Arg 
1               5                   10                  15      


Ser Glu Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr 
            20                  25                  30          


Ser Tyr Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg 
        35                  40                  45              


Ala Leu Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr 
    50                  55                  60                  


Val Gly Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr 
65                  70                  75                  80  


Arg Arg Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile 
                85                  90                  95      


Ser Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val 
            100                 105                 110         


Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser 
        115                 120                 125             


Gly Phe Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu 
    130                 135                 140                 


Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu 
145                 150                 155                 160 


Arg Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp 
                165                 170                 175     


Gly Leu Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr 
            180                 185                 190         


Glu Glu Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp 
        195                 200                 205             


Thr Val Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe 
    210                 215                 220                 


Cys Leu Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile 
225                 230                 235                 240 


Ile Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile 
                245                 250                 255     


Arg Leu Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro 
            260                 265                 270         


Tyr Asn Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly 
        275                 280                 285             


Asn Asp Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr 
    290                 295                 300                 


Glu Val Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala 
305                 310                 315                 320 


Phe Val Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg 
                325                 330                 335     


His Leu Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu 
            340                 345                 350         


Lys Leu Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu 
        355                 360                 365             


Leu Ser Ile Val Phe 
    370             


<210>  1773
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR4__Homo_sapiens__NP_005499

<400>  1773

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  1774
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5__Homo_sapiens__NP_000570

<400>  1774

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  1775
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR6__Homo_sapiens__NP_004358

<400>  1775

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  1776
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR7__Homo_sapiens__NP_001829

<400>  1776

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  1777
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR8__Homo_sapiens__NP_005192

<400>  1777

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  1778
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR9__Homo_sapiens__NP_001243298

<400>  1778

Met Ala Asp Asp Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr 
1               5                   10                  15      


Val Asn Phe Asn Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg 
            20                  25                  30          


Gln Phe Ala Ser His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile 
        35                  40                  45              


Val Gly Ala Leu Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys 
    50                  55                  60                  


Thr Arg Val Lys Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile 
65                  70                  75                  80  


Ala Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala 
                85                  90                  95      


Ala Asp Gln Trp Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser 
            100                 105                 110         


Met Tyr Lys Met Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile 
        115                 120                 125             


Ser Val Asp Arg Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr 
    130                 135                 140                 


Trp Arg Glu Lys Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile 
145                 150                 155                 160 


Trp Val Leu Ala Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln 
                165                 170                 175     


Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser 
            180                 185                 190         


Asp Glu Ser Thr Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile 
        195                 200                 205             


Leu Gly Phe Phe Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile 
    210                 215                 220                 


Ile Ile His Thr Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala 
225                 230                 235                 240 


Leu Lys Val Thr Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe 
                245                 250                 255     


Pro Tyr Asn Cys Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met 
            260                 265                 270         


Phe Ile Ser Asn Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln 
        275                 280                 285             


Val Thr Gln Thr Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu 
    290                 295                 300                 


Tyr Val Phe Val Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu 
305                 310                 315                 320 


Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg 
                325                 330                 335     


Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser 
            340                 345                 350         


Gly Ala Leu Ser Leu 
        355         


<210>  1779
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCRL2__Homo_sapiens__NP_001124382

<400>  1779

Met Ile Tyr Thr Arg Phe Leu Lys Gly Ser Leu Lys Met Ala Asn Tyr 
1               5                   10                  15      


Thr Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile Glu Gly Glu Leu 
            20                  25                  30          


Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp Ala Gln Ala Leu 
        35                  40                  45              


Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val Phe Val Ile Gly 
    50                  55                  60                  


Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val Lys Tyr Lys Gly 
65                  70                  75                  80  


Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu Ala Val Ser Asn 
                85                  90                  95      


Leu Cys Phe Leu Leu Thr Leu Pro Phe Trp Ala His Ala Gly Gly Asp 
            100                 105                 110         


Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val Gly Leu Tyr Ser 
        115                 120                 125             


Glu Thr Phe Phe Asn Cys Leu Leu Thr Val Gln Arg Tyr Leu Val Phe 
    130                 135                 140                 


Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg Val Pro Cys Gly 
145                 150                 155                 160 


Ile Ile Thr Ser Val Leu Ala Trp Val Thr Ala Ile Leu Ala Thr Leu 
                165                 170                 175     


Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp Gln Lys Tyr Lys 
            180                 185                 190         


Cys Ala Phe Ser Arg Thr Pro Phe Leu Pro Ala Asp Glu Thr Phe Trp 
        195                 200                 205             


Lys His Phe Leu Thr Leu Lys Met Asn Ile Ser Val Leu Val Leu Pro 
    210                 215                 220                 


Leu Phe Ile Phe Thr Phe Leu Tyr Val Gln Met Arg Lys Thr Leu Arg 
225                 230                 235                 240 


Phe Arg Glu Gln Arg Tyr Ser Leu Phe Lys Leu Val Phe Ala Ile Met 
                245                 250                 255     


Val Val Phe Leu Leu Met Trp Ala Pro Tyr Asn Ile Ala Phe Phe Leu 
            260                 265                 270         


Ser Thr Phe Lys Glu His Phe Ser Leu Ser Asp Cys Lys Ser Ser Tyr 
        275                 280                 285             


Asn Leu Asp Lys Ser Val His Ile Thr Lys Leu Ile Ala Thr Thr His 
    290                 295                 300                 


Cys Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Asp Gly Thr Phe Ser 
305                 310                 315                 320 


Lys Tyr Leu Cys Arg Cys Phe His Leu Arg Ser Asn Thr Pro Leu Gln 
                325                 330                 335     


Pro Arg Gly Gln Ser Ala Gln Gly Thr Ser Arg Glu Glu Pro Asp His 
            340                 345                 350         


Ser Thr Glu Val 
        355     


<210>  1780
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCRN4L__Homo_sapiens__NP_036250

<400>  1780

Met Phe His Ser Pro Arg Arg Leu Cys Ser Ala Leu Leu Gln Arg Asp 
1               5                   10                  15      


Ala Pro Gly Leu Arg Arg Leu Pro Ala Pro Gly Leu Arg Arg Pro Leu 
            20                  25                  30          


Ser Pro Pro Ala Ala Val Pro Arg Pro Ala Ser Pro Arg Leu Leu Ala 
        35                  40                  45              


Ala Ala Ser Ala Ala Ser Gly Ala Ala Arg Ser Cys Ser Arg Thr Val 
    50                  55                  60                  


Cys Ser Met Gly Thr Gly Thr Ser Arg Leu Tyr Ser Ala Leu Ala Lys 
65                  70                  75                  80  


Thr Leu Asn Ser Ser Ala Ala Ser Gln His Pro Glu Tyr Leu Val Ser 
                85                  90                  95      


Pro Asp Pro Glu His Leu Glu Pro Ile Asp Pro Lys Glu Leu Leu Glu 
            100                 105                 110         


Glu Cys Arg Ala Val Leu His Thr Arg Pro Pro Arg Phe Gln Arg Asp 
        115                 120                 125             


Phe Val Asp Leu Arg Thr Asp Cys Pro Ser Thr His Pro Pro Ile Arg 
    130                 135                 140                 


Val Met Gln Trp Asn Ile Leu Ala Gln Ala Leu Gly Glu Gly Lys Asp 
145                 150                 155                 160 


Asn Phe Val Gln Cys Pro Val Glu Ala Leu Lys Trp Glu Glu Arg Lys 
                165                 170                 175     


Cys Leu Ile Leu Glu Glu Ile Leu Ala Tyr Gln Pro Asp Ile Leu Cys 
            180                 185                 190         


Leu Gln Glu Val Asp His Tyr Phe Asp Thr Phe Gln Pro Leu Leu Ser 
        195                 200                 205             


Arg Leu Gly Tyr Gln Gly Thr Phe Phe Pro Lys Pro Trp Ser Pro Cys 
    210                 215                 220                 


Leu Asp Val Glu His Asn Asn Gly Pro Asp Gly Cys Ala Leu Phe Phe 
225                 230                 235                 240 


Leu Gln Asn Arg Phe Lys Leu Val Asn Ser Ala Asn Ile Arg Leu Thr 
                245                 250                 255     


Ala Met Thr Leu Lys Thr Asn Gln Val Ala Ile Ala Gln Thr Leu Glu 
            260                 265                 270         


Cys Lys Glu Ser Gly Arg Gln Phe Cys Ile Ala Val Thr His Leu Lys 
        275                 280                 285             


Ala Arg Thr Gly Trp Glu Arg Phe Arg Ser Ala Gln Gly Cys Asp Leu 
    290                 295                 300                 


Leu Gln Asn Leu Gln Asn Ile Thr Gln Gly Ala Lys Ile Pro Leu Ile 
305                 310                 315                 320 


Val Cys Gly Asp Phe Asn Ala Glu Pro Thr Glu Glu Val Tyr Lys His 
                325                 330                 335     


Phe Ala Ser Ser Ser Leu Asn Leu Asn Ser Ala Tyr Lys Leu Leu Ser 
            340                 345                 350         


Ala Asp Gly Gln Ser Glu Pro Pro Tyr Thr Thr Trp Lys Ile Arg Thr 
        355                 360                 365             


Ser Gly Glu Cys Arg His Thr Leu Asp Tyr Ile Trp Tyr Ser Lys His 
    370                 375                 380                 


Ala Leu Asn Val Arg Ser Ala Leu Asp Leu Leu Thr Glu Glu Gln Ile 
385                 390                 395                 400 


Gly Pro Asn Arg Leu Pro Ser Phe Asn Tyr Pro Ser Asp His Leu Ser 
                405                 410                 415     


Leu Val Cys Asp Phe Ser Phe Thr Glu Glu Ser Asp Gly Leu Ser 
            420                 425                 430     


<210>  1781
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCSER1__Homo_sapiens__NP_001138537

<400>  1781

Met Gly Asp Ser Gly Ser Arg Arg Ser Thr Leu Val Ser Arg Leu Pro 
1               5                   10                  15      


Ile Phe Arg Arg Ser Ile Asn Arg Arg His Asp Ser Leu Pro Ser Ser 
            20                  25                  30          


Pro Ser Ser Ser Asn Thr Val Gly Val His Ser Ser Ser Pro Ser Ser 
        35                  40                  45              


Thr Asn Ser Ser Ser Gly Ser Thr Gly Lys Arg Arg Ser Ile Phe Arg 
    50                  55                  60                  


Thr Pro Ser Ile Ser Phe His His Lys Lys Gly Ser Glu Pro Lys Gln 
65                  70                  75                  80  


Glu Pro Thr Asn Gln Asn Leu Ser Ile Ser Asn Gly Ala Gln Pro Gly 
                85                  90                  95      


His Ser Asn Met Gln Lys Leu Ser Leu Glu Glu His Ile Lys Thr Arg 
            100                 105                 110         


Gly Arg His Ser Val Gly Phe Ser Ser Ser Arg Asn Lys Lys Ile Thr 
        115                 120                 125             


Arg Ser Leu Thr Glu Asp Phe Glu Arg Glu Lys Glu His Ser Thr Asn 
    130                 135                 140                 


Lys Asn Val Phe Ile Asn Cys Leu Ser Ser Gly Lys Ser Glu Gly Asp 
145                 150                 155                 160 


Asp Ser Gly Phe Thr Glu Asp Gln Thr Arg Arg Ser Val Lys Gln Ser 
                165                 170                 175     


Thr Arg Lys Leu Leu Pro Lys Ser Phe Ser Ser His Tyr Lys Phe Ser 
            180                 185                 190         


Lys Pro Val Leu Gln Ser Gln Ser Ile Ser Leu Val Gln Gln Ser Glu 
        195                 200                 205             


Phe Ser Leu Glu Val Thr Gln Tyr Gln Glu Arg Glu Pro Val Leu Val 
    210                 215                 220                 


Arg Ala Ser Pro Ser Cys Ser Val Asp Val Thr Glu Arg Ala Gly Ser 
225                 230                 235                 240 


Ser Leu Gln Ser Pro Leu Leu Ser Ala Asp Leu Thr Thr Ala Gln Thr 
                245                 250                 255     


Pro Ser Glu Phe Leu Ala Leu Thr Glu Asp Ser Val Ser Glu Met Asp 
            260                 265                 270         


Ala Phe Ser Lys Ser Gly Ser Met Ala Ser His Cys Asp Asn Phe Gly 
        275                 280                 285             


His Asn Asp Ser Thr Ser Gln Met Ser Leu Asn Ser Ala Ala Val Thr 
    290                 295                 300                 


Lys Thr Thr Thr Glu Leu Thr Gly Thr Val Pro Cys Ala Ile Met Ser 
305                 310                 315                 320 


Pro Gly Lys Tyr Arg Leu Glu Gly Gln Cys Ser Thr Glu Ser Asn Ser 
                325                 330                 335     


Leu Pro Glu Thr Ser Ala Ala Asn Gln Lys Glu Val Leu Leu Gln Ile 
            340                 345                 350         


Ala Glu Leu Pro Ala Thr Ser Val Ser His Ser Glu Ser Asn Leu Pro 
        355                 360                 365             


Ala Asp Ser Glu Arg Glu Glu Asn Ile Gly Leu Gln Asn Gly Glu Thr 
    370                 375                 380                 


Met Leu Gly Thr Asn Ser Pro Arg Lys Leu Gly Phe Tyr Glu Gln His 
385                 390                 395                 400 


Lys Ala Ile Ala Glu His Val Lys Gly Ile His Pro Ile Ser Asp Ser 
                405                 410                 415     


Lys Ile Ile Pro Thr Ser Gly Asp His His Ile Phe Asn Lys Thr Ser 
            420                 425                 430         


His Gly Tyr Glu Ala Asn Pro Ala Lys Val Leu Ala Ser Ser Leu Ser 
        435                 440                 445             


Pro Phe Arg Glu Gly Arg Phe Ile Glu Arg Arg Leu Arg Ser Ser Ser 
    450                 455                 460                 


Glu Gly Thr Ala Gly Ser Ser Arg Met Ile Leu Lys Pro Lys Asp Gly 
465                 470                 475                 480 


Asn Ile Glu Glu Val Asn Ser Leu Arg Lys Gln Arg Ala Gly Ser Ser 
                485                 490                 495     


Ser Ser Lys Met Asn Ser Leu Asp Val Leu Asn Asn Leu Gly Ser Cys 
            500                 505                 510         


Glu Leu Asp Glu Asp Asp Leu Met Leu Asp Leu Glu Phe Leu Glu Glu 
        515                 520                 525             


Gln Ser Leu His Pro Ser Val Cys Arg Glu Asp Ser Tyr His Ser Val 
    530                 535                 540                 


Val Ser Cys Ala Ala Val Val Leu Thr Pro Met Glu Pro Met Ile Glu 
545                 550                 555                 560 


Met Lys Lys Arg Glu Glu Pro Glu Phe Pro Glu Pro Ser Lys Gln Asn 
                565                 570                 575     


Leu Ser Leu Lys Leu Thr Lys Asp Val Asp Gln Glu Ala Arg Cys Ser 
            580                 585                 590         


His Ile Ser Arg Met Pro Asn Ser Pro Ser Ala Asp Trp Pro Leu Gln 
        595                 600                 605             


Gly Val Glu Glu Asn Gly Gly Ile Asp Ser Leu Pro Phe Arg Leu Met 
    610                 615                 620                 


Leu Gln Asp Cys Thr Ala Val Lys Thr Leu Leu Leu Lys Met Lys Arg 
625                 630                 635                 640 


Val Leu Gln Glu Ser Ala Asp Met Ser Pro Ala Ser Ser Thr Thr Ser 
                645                 650                 655     


Leu Pro Val Ser Pro Leu Thr Glu Glu Pro Val Pro Phe Lys Asp Ile 
            660                 665                 670         


Met Lys Asp Glu Cys Ser Met Leu Lys Leu Gln Leu Lys Glu Lys Asp 
        675                 680                 685             


Glu Leu Ile Ser Gln Leu Gln Glu Glu Leu Gly Lys Val Arg His Leu 
    690                 695                 700                 


Gln Lys Ala Phe Ala Ser Arg Val Asp Lys Ser Thr Gln Thr Glu Leu 
705                 710                 715                 720 


Leu Cys Tyr Asp Gly Leu Asn Leu Lys Arg Leu Glu Thr Val Gln Gly 
                725                 730                 735     


Gly Arg Glu Ala Thr Tyr Arg Asn Arg Ile Val Ser Gln Asn Leu Ser 
            740                 745                 750         


Thr Arg Asp Arg Lys Ala Ile His Thr Pro Thr Glu Asp Arg Phe Arg 
        755                 760                 765             


Tyr Ser Ala Ala Asp Gln Thr Ser Pro Tyr Lys Asn Lys Thr Cys Gln 
    770                 775                 780                 


Leu Pro Ser Leu Cys Leu Ser Asn Phe Leu Lys Asp Lys Glu Leu Ala 
785                 790                 795                 800 


Glu Val Ile Lys His Ser Arg Gly Thr Tyr Glu Thr Leu Thr Ser Asp 
                805                 810                 815     


Val Thr Gln Asn Leu Arg Ala Thr Val Gly Gln Ser Ser Leu Lys Pro 
            820                 825                 830         


Thr Ala Lys Thr Glu Gly Leu Ser Thr Phe Leu Glu Lys Pro Lys Asp 
        835                 840                 845             


Gln Val Ala Thr Ala Arg Gln His Ser Thr Phe Thr Gly Arg Phe Gly 
    850                 855                 860                 


Gln Pro Pro Arg Gly Pro Ile Ser Leu His Met Tyr Ser Arg Lys Asn 
865                 870                 875                 880 


Val Phe Leu His His Asn Leu His Ser Thr Glu Leu Gln Thr Leu Gly 
                885                 890                 895     


Gln Gln Asp Gly 
            900 


<210>  1782
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCS__Homo_sapiens__NP_005116

<400>  1782

Met Ala Ser Asp Ser Gly Asn Gln Gly Thr Leu Cys Thr Leu Glu Phe 
1               5                   10                  15      


Ala Val Gln Met Thr Cys Gln Ser Cys Val Asp Ala Val Arg Lys Ser 
            20                  25                  30          


Leu Gln Gly Val Ala Gly Val Gln Asp Val Glu Val His Leu Glu Asp 
        35                  40                  45              


Gln Met Val Leu Val His Thr Thr Leu Pro Ser Gln Glu Val Gln Ala 
    50                  55                  60                  


Leu Leu Glu Gly Thr Gly Arg Gln Ala Val Leu Lys Gly Met Gly Ser 
65                  70                  75                  80  


Gly Gln Leu Gln Asn Leu Gly Ala Ala Val Ala Ile Leu Gly Gly Pro 
                85                  90                  95      


Gly Thr Val Gln Gly Val Val Arg Phe Leu Gln Leu Thr Pro Glu Arg 
            100                 105                 110         


Cys Leu Ile Glu Gly Thr Ile Asp Gly Leu Glu Pro Gly Leu His Gly 
        115                 120                 125             


Leu His Val His Gln Tyr Gly Asp Leu Thr Asn Asn Cys Asn Ser Cys 
    130                 135                 140                 


Gly Asn His Phe Asn Pro Asp Gly Ala Ser His Gly Gly Pro Gln Asp 
145                 150                 155                 160 


Ser Asp Arg His Arg Gly Asp Leu Gly Asn Val Arg Ala Asp Ala Asp 
                165                 170                 175     


Gly Arg Ala Ile Phe Arg Met Glu Asp Glu Gln Leu Lys Val Trp Asp 
            180                 185                 190         


Val Ile Gly Arg Ser Leu Ile Ile Asp Glu Gly Glu Asp Asp Leu Gly 
        195                 200                 205             


Arg Gly Gly His Pro Leu Ser Lys Ile Thr Gly Asn Ser Gly Glu Arg 
    210                 215                 220                 


Leu Ala Cys Gly Ile Ile Ala Arg Ser Ala Gly Leu Phe Gln Asn Pro 
225                 230                 235                 240 


Lys Gln Ile Cys Ser Cys Asp Gly Leu Thr Ile Trp Glu Glu Arg Gly 
                245                 250                 255     


Arg Pro Ile Ala Gly Lys Gly Arg Lys Glu Ser Ala Gln Pro Pro Ala 
            260                 265                 270         


His Leu 
        


<210>  1783
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCT2__Homo_sapiens__NP_006422

<400>  1783

Met Ala Ser Leu Ser Leu Ala Pro Val Asn Ile Phe Lys Ala Gly Ala 
1               5                   10                  15      


Asp Glu Glu Arg Ala Glu Thr Ala Arg Leu Thr Ser Phe Ile Gly Ala 
            20                  25                  30          


Ile Ala Ile Gly Asp Leu Val Lys Ser Thr Leu Gly Pro Lys Gly Met 
        35                  40                  45              


Asp Lys Ile Leu Leu Ser Ser Gly Arg Asp Ala Ser Leu Met Val Thr 
    50                  55                  60                  


Asn Asp Gly Ala Thr Ile Leu Lys Asn Ile Gly Val Asp Asn Pro Ala 
65                  70                  75                  80  


Ala Lys Val Leu Val Asp Met Ser Arg Val Gln Asp Asp Glu Val Gly 
                85                  90                  95      


Asp Gly Thr Thr Ser Val Thr Val Leu Ala Ala Glu Leu Leu Arg Glu 
            100                 105                 110         


Ala Glu Ser Leu Ile Ala Lys Lys Ile His Pro Gln Thr Ile Ile Ala 
        115                 120                 125             


Gly Trp Arg Glu Ala Thr Lys Ala Ala Arg Glu Ala Leu Leu Ser Ser 
    130                 135                 140                 


Ala Val Asp His Gly Ser Asp Glu Val Lys Phe Arg Gln Asp Leu Met 
145                 150                 155                 160 


Asn Ile Ala Gly Thr Thr Leu Ser Ser Lys Leu Leu Thr His His Lys 
                165                 170                 175     


Asp His Phe Thr Lys Leu Ala Val Glu Ala Val Leu Arg Leu Lys Gly 
            180                 185                 190         


Ser Gly Asn Leu Glu Ala Ile His Ile Ile Lys Lys Leu Gly Gly Ser 
        195                 200                 205             


Leu Ala Asp Ser Tyr Leu Asp Glu Gly Phe Leu Leu Asp Lys Lys Ile 
    210                 215                 220                 


Gly Val Asn Gln Pro Lys Arg Ile Glu Asn Ala Lys Ile Leu Ile Ala 
225                 230                 235                 240 


Asn Thr Gly Met Asp Thr Asp Lys Ile Lys Ile Phe Gly Ser Arg Val 
                245                 250                 255     


Arg Val Asp Ser Thr Ala Lys Val Ala Glu Ile Glu His Ala Glu Lys 
            260                 265                 270         


Glu Lys Met Lys Glu Lys Val Glu Arg Ile Leu Lys His Gly Ile Asn 
        275                 280                 285             


Cys Phe Ile Asn Arg Gln Leu Ile Tyr Asn Tyr Pro Glu Gln Leu Phe 
    290                 295                 300                 


Gly Ala Ala Gly Val Met Ala Ile Glu His Ala Asp Phe Ala Gly Val 
305                 310                 315                 320 


Glu Arg Leu Ala Leu Val Thr Gly Gly Glu Ile Ala Ser Thr Phe Asp 
                325                 330                 335     


His Pro Glu Leu Val Lys Leu Gly Ser Cys Lys Leu Ile Glu Glu Val 
            340                 345                 350         


Met Ile Gly Glu Asp Lys Leu Ile His Phe Ser Gly Val Ala Leu Gly 
        355                 360                 365             


Glu Ala Cys Thr Ile Val Leu Arg Gly Ala Thr Gln Gln Ile Leu Asp 
    370                 375                 380                 


Glu Ala Glu Arg Ser Leu His Asp Ala Leu Cys Val Leu Ala Gln Thr 
385                 390                 395                 400 


Val Lys Asp Ser Arg Thr Val Tyr Gly Gly Gly Cys Ser Glu Met Leu 
                405                 410                 415     


Met Ala His Ala Val Thr Gln Leu Ala Asn Arg Thr Pro Gly Lys Glu 
            420                 425                 430         


Ala Val Ala Met Glu Ser Tyr Ala Lys Ala Leu Arg Met Leu Pro Thr 
        435                 440                 445             


Ile Ile Ala Asp Asn Ala Gly Tyr Asp Ser Ala Asp Leu Val Ala Gln 
    450                 455                 460                 


Leu Arg Ala Ala His Ser Glu Gly Asn Thr Thr Ala Gly Leu Asp Met 
465                 470                 475                 480 


Arg Glu Gly Thr Ile Gly Asp Met Ala Ile Leu Gly Ile Thr Glu Ser 
                485                 490                 495     


Phe Gln Val Lys Arg Gln Val Leu Leu Ser Ala Ala Glu Ala Ala Glu 
            500                 505                 510         


Val Ile Leu Arg Val Asp Asn Ile Ile Lys Ala Ala Pro Arg Lys Arg 
        515                 520                 525             


Val Pro Asp His His Pro Cys 
    530                 535 


<210>  1784
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCT3__Homo_sapiens__NP_001008800

<400>  1784

Met Met Gly His Arg Pro Val Leu Val Leu Ser Gln Asn Thr Lys Arg 
1               5                   10                  15      


Glu Ser Gly Arg Lys Val Gln Ser Gly Asn Ile Asn Ala Ala Lys Ile 
            20                  25                  30          


Gln Val Gln His Pro Ala Ala Lys Ser Met Ile Glu Ile Ser Arg Thr 
        35                  40                  45              


Gln Asp Glu Glu Val Gly Asp Gly Thr Thr Ser Val Ile Ile Leu Ala 
    50                  55                  60                  


Gly Glu Met Leu Ser Val Ala Glu His Phe Leu Glu Gln Gln Met His 
65                  70                  75                  80  


Pro Thr Val Val Ile Ser Ala Tyr Arg Lys Ala Leu Asp Asp Met Ile 
                85                  90                  95      


Ser Thr Leu Lys Lys Ile Ser Ile Pro Val Asp Ile Ser Asp Ser Asp 
            100                 105                 110         


Met Met Leu Asn Ile Ile Asn Ser Ser Ile Thr Thr Lys Ala Ile Ser 
        115                 120                 125             


Arg Trp Ser Ser Leu Ala Cys Asn Ile Ala Leu Asp Ala Val Lys Met 
    130                 135                 140                 


Val Gln Phe Glu Glu Asn Gly Arg Lys Glu Ile Asp Ile Lys Lys Tyr 
145                 150                 155                 160 


Ala Arg Val Glu Lys Ile Pro Gly Gly Ile Ile Glu Asp Ser Cys Val 
                165                 170                 175     


Leu Arg Gly Val Met Ile Asn Lys Asp Val Thr His Pro Arg Met Arg 
            180                 185                 190         


Arg Tyr Ile Lys Asn Pro Arg Ile Val Leu Leu Asp Ser Ser Leu Glu 
        195                 200                 205             


Tyr Lys Lys Gly Glu Ser Gln Thr Asp Ile Glu Ile Thr Arg Glu Glu 
    210                 215                 220                 


Asp Phe Thr Arg Ile Leu Gln Met Glu Glu Glu Tyr Ile Gln Gln Leu 
225                 230                 235                 240 


Cys Glu Asp Ile Ile Gln Leu Lys Pro Asp Val Val Ile Thr Glu Lys 
                245                 250                 255     


Gly Ile Ser Asp Leu Ala Gln His Tyr Leu Met Arg Ala Asn Ile Thr 
            260                 265                 270         


Ala Ile Arg Arg Val Arg Lys Thr Asp Asn Asn Arg Ile Ala Arg Ala 
        275                 280                 285             


Cys Gly Ala Arg Ile Val Ser Arg Pro Glu Glu Leu Arg Glu Asp Asp 
    290                 295                 300                 


Val Gly Thr Gly Ala Gly Leu Leu Glu Ile Lys Lys Ile Gly Asp Glu 
305                 310                 315                 320 


Tyr Phe Thr Phe Ile Thr Asp Cys Lys Asp Pro Lys Ala Cys Thr Ile 
                325                 330                 335     


Leu Leu Arg Gly Ala Ser Lys Glu Ile Leu Ser Glu Val Glu Arg Asn 
            340                 345                 350         


Leu Gln Asp Ala Met Gln Val Cys Arg Asn Val Leu Leu Asp Pro Gln 
        355                 360                 365             


Leu Val Pro Gly Gly Gly Ala Ser Glu Met Ala Val Ala His Ala Leu 
    370                 375                 380                 


Thr Glu Lys Ser Lys Ala Met Thr Gly Val Glu Gln Trp Pro Tyr Arg 
385                 390                 395                 400 


Ala Val Ala Gln Ala Leu Glu Val Ile Pro Arg Thr Leu Ile Gln Asn 
                405                 410                 415     


Cys Gly Ala Ser Thr Ile Arg Leu Leu Thr Ser Leu Arg Ala Lys His 
            420                 425                 430         


Thr Gln Glu Asn Cys Glu Thr Trp Gly Val Asn Gly Glu Thr Gly Thr 
        435                 440                 445             


Leu Val Asp Met Lys Glu Leu Gly Ile Trp Glu Pro Leu Ala Val Lys 
    450                 455                 460                 


Leu Gln Thr Tyr Lys Thr Ala Val Glu Thr Ala Val Leu Leu Leu Arg 
465                 470                 475                 480 


Ile Asp Asp Ile Val Ser Gly His Lys Lys Lys Gly Asp Asp Gln Ser 
                485                 490                 495     


Arg Gln Gly Gly Ala Pro Asp Ala Gly Gln Glu 
            500                 505         


<210>  1785
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCT4__Homo_sapiens__NP_001243650

<400>  1785

Met Pro Glu Asn Val Ala Pro Arg Ser Gly Ala Thr Ala Gly Ala Ala 
1               5                   10                  15      


Gly Gly Arg Gly Lys Gly Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln 
            20                  25                  30          


Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile 
        35                  40                  45              


Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Leu Val Glu Leu 
    50                  55                  60                  


Ser Lys Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val 
65                  70                  75                  80  


Ile Ile Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys 
                85                  90                  95      


Gly Ile His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu 
            100                 105                 110         


Lys Gly Ile Glu Ile Leu Thr Asp Met Ser Arg Pro Val Glu Leu Ser 
        115                 120                 125             


Asp Arg Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys 
    130                 135                 140                 


Val Val Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala 
145                 150                 155                 160 


Val Met Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg 
                165                 170                 175     


Asp Ile Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu 
            180                 185                 190         


Leu Val Glu Gly Leu Val Leu Thr Gln Lys Val Ser Asn Ser Gly Ile 
        195                 200                 205             


Thr Arg Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser 
    210                 215                 220                 


Ala Pro Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala 
225                 230                 235                 240 


Gln Met Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu 
                245                 250                 255     


Val Lys Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys 
            260                 265                 270         


Ser Ile Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn 
        275                 280                 285             


Lys Met Lys Ile Met Val Ile Lys Asp Ile Glu Arg Glu Asp Ile Glu 
    290                 295                 300                 


Phe Ile Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln 
305                 310                 315                 320 


Phe Thr Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Asn 
                325                 330                 335     


Leu Asn Gly Ser Gly Lys Leu Leu Lys Ile Thr Gly Cys Ala Ser Pro 
            340                 345                 350         


Gly Lys Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile 
        355                 360                 365             


Glu Glu Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys 
    370                 375                 380                 


Leu Val Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile 
385                 390                 395                 400 


Glu Leu Ala Leu Arg Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met 
                405                 410                 415     


Glu Ser Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro 
            420                 425                 430         


Ser Thr Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr 
        435                 440                 445             


Glu Leu Arg Asn Arg His Ala Gln Gly Glu Lys Thr Ala Gly Ile Asn 
    450                 455                 460                 


Val Arg Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Leu Val Val Gln 
465                 470                 475                 480 


Pro Leu Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val 
                485                 490                 495     


Arg Ser Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg 
            500                 505                 


<210>  1786
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCT5__Homo_sapiens__NP_036205

<400>  1786

Met Ala Ser Met Gly Thr Leu Ala Phe Asp Glu Tyr Gly Arg Pro Phe 
1               5                   10                  15      


Leu Ile Ile Lys Asp Gln Asp Arg Lys Ser Arg Leu Met Gly Leu Glu 
            20                  25                  30          


Ala Leu Lys Ser His Ile Met Ala Ala Lys Ala Val Ala Asn Thr Met 
        35                  40                  45              


Arg Thr Ser Leu Gly Pro Asn Gly Leu Asp Lys Met Met Val Asp Lys 
    50                  55                  60                  


Asp Gly Asp Val Thr Val Thr Asn Asp Gly Ala Thr Ile Leu Ser Met 
65                  70                  75                  80  


Met Asp Val Asp His Gln Ile Ala Lys Leu Met Val Glu Leu Ser Lys 
                85                  90                  95      


Ser Gln Asp Asp Glu Ile Gly Asp Gly Thr Thr Gly Val Val Val Leu 
            100                 105                 110         


Ala Gly Ala Leu Leu Glu Glu Ala Glu Gln Leu Leu Asp Arg Gly Ile 
        115                 120                 125             


His Pro Ile Arg Ile Ala Asp Gly Tyr Glu Gln Ala Ala Arg Val Ala 
    130                 135                 140                 


Ile Glu His Leu Asp Lys Ile Ser Asp Ser Val Leu Val Asp Ile Lys 
145                 150                 155                 160 


Asp Thr Glu Pro Leu Ile Gln Thr Ala Lys Thr Thr Leu Gly Ser Lys 
                165                 170                 175     


Val Val Asn Ser Cys His Arg Gln Met Ala Glu Ile Ala Val Asn Ala 
            180                 185                 190         


Val Leu Thr Val Ala Asp Met Glu Arg Arg Asp Val Asp Phe Glu Leu 
        195                 200                 205             


Ile Lys Val Glu Gly Lys Val Gly Gly Arg Leu Glu Asp Thr Lys Leu 
    210                 215                 220                 


Ile Lys Gly Val Ile Val Asp Lys Asp Phe Ser His Pro Gln Met Pro 
225                 230                 235                 240 


Lys Lys Val Glu Asp Ala Lys Ile Ala Ile Leu Thr Cys Pro Phe Glu 
                245                 250                 255     


Pro Pro Lys Pro Lys Thr Lys His Lys Leu Asp Val Thr Ser Val Glu 
            260                 265                 270         


Asp Tyr Lys Ala Leu Gln Lys Tyr Glu Lys Glu Lys Phe Glu Glu Met 
        275                 280                 285             


Ile Gln Gln Ile Lys Glu Thr Gly Ala Asn Leu Ala Ile Cys Gln Trp 
    290                 295                 300                 


Gly Phe Asp Asp Glu Ala Asn His Leu Leu Leu Gln Asn Asn Leu Pro 
305                 310                 315                 320 


Ala Val Arg Trp Val Gly Gly Pro Glu Ile Glu Leu Ile Ala Ile Ala 
                325                 330                 335     


Thr Gly Gly Arg Ile Val Pro Arg Phe Ser Glu Leu Thr Ala Glu Lys 
            340                 345                 350         


Leu Gly Phe Ala Gly Leu Val Gln Glu Ile Ser Phe Gly Thr Thr Lys 
        355                 360                 365             


Asp Lys Met Leu Val Ile Glu Gln Cys Lys Asn Ser Arg Ala Val Thr 
    370                 375                 380                 


Ile Phe Ile Arg Gly Gly Asn Lys Met Ile Ile Glu Glu Ala Lys Arg 
385                 390                 395                 400 


Ser Leu His Asp Ala Leu Cys Val Ile Arg Asn Leu Ile Arg Asp Asn 
                405                 410                 415     


Arg Val Val Tyr Gly Gly Gly Ala Ala Glu Ile Ser Cys Ala Leu Ala 
            420                 425                 430         


Val Ser Gln Glu Ala Asp Lys Cys Pro Thr Leu Glu Gln Tyr Ala Met 
        435                 440                 445             


Arg Ala Phe Ala Asp Ala Leu Glu Val Ile Pro Met Ala Leu Ser Glu 
    450                 455                 460                 


Asn Ser Gly Met Asn Pro Ile Gln Thr Met Thr Glu Val Arg Ala Arg 
465                 470                 475                 480 


Gln Val Lys Glu Met Asn Pro Ala Leu Gly Ile Asp Cys Leu His Lys 
                485                 490                 495     


Gly Thr Asn Asp Met Lys Gln Gln His Val Ile Glu Thr Leu Ile Gly 
            500                 505                 510         


Lys Lys Gln Gln Ile Ser Leu Ala Thr Gln Met Val Arg Met Ile Leu 
        515                 520                 525             


Lys Ile Asp Asp Ile Arg Lys Pro Gly Glu Ser Glu Glu 
    530                 535                 540     


<210>  1787
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCT6A__Homo_sapiens__NP_001009186

<400>  1787

Met Ala Ala Val Lys Thr Leu Asn Pro Lys Ala Glu Val Ala Arg Ala 
1               5                   10                  15      


Gln Ala Ala Leu Ala Val Asn Ile Ser Ala Ala Arg Gly Leu Gln Asp 
            20                  25                  30          


Val Leu Arg Thr Asn Leu Gly Pro Lys Gly Thr Met Lys Met Leu Val 
        35                  40                  45              


Ser Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu Leu 
    50                  55                  60                  


His Glu Met Gly Leu His Pro Arg Ile Ile Thr Glu Gly Phe Glu Ala 
65                  70                  75                  80  


Ala Lys Glu Lys Ala Leu Gln Phe Leu Glu Glu Val Lys Val Ser Arg 
                85                  90                  95      


Glu Met Asp Arg Glu Thr Leu Ile Asp Val Ala Arg Thr Ser Leu Arg 
            100                 105                 110         


Thr Lys Val His Ala Glu Leu Ala Asp Val Leu Thr Glu Ala Val Val 
        115                 120                 125             


Asp Ser Ile Leu Ala Ile Lys Lys Gln Asp Glu Pro Ile Asp Leu Phe 
    130                 135                 140                 


Met Ile Glu Ile Met Glu Met Lys His Lys Ser Glu Thr Asp Thr Ser 
145                 150                 155                 160 


Leu Ile Arg Gly Leu Val Leu Asp His Gly Ala Arg His Pro Asp Met 
                165                 170                 175     


Lys Lys Arg Val Glu Asp Ala Tyr Ile Leu Thr Cys Asn Val Ser Leu 
            180                 185                 190         


Glu Tyr Glu Lys Thr Glu Val Asn Ser Gly Phe Phe Tyr Lys Ser Ala 
        195                 200                 205             


Glu Glu Arg Glu Lys Leu Val Lys Ala Glu Arg Lys Phe Ile Glu Asp 
    210                 215                 220                 


Arg Val Lys Lys Ile Ile Glu Leu Lys Arg Lys Val Cys Gly Asp Ser 
225                 230                 235                 240 


Asp Lys Gly Phe Val Val Ile Asn Gln Lys Gly Ile Asp Pro Phe Ser 
                245                 250                 255     


Leu Asp Ala Leu Ser Lys Glu Gly Ile Val Ala Leu Arg Arg Ala Lys 
            260                 265                 270         


Arg Arg Asn Met Glu Arg Leu Thr Leu Ala Cys Gly Gly Val Ala Leu 
        275                 280                 285             


Asn Ser Phe Asp Asp Leu Ser Pro Asp Cys Leu Gly His Ala Gly Leu 
    290                 295                 300                 


Val Tyr Glu Tyr Thr Leu Gly Glu Glu Lys Phe Thr Phe Ile Glu Lys 
305                 310                 315                 320 


Cys Asn Asn Pro Arg Ser Val Thr Leu Leu Ile Lys Gly Pro Asn Lys 
                325                 330                 335     


His Thr Leu Thr Gln Ile Lys Asp Ala Val Arg Asp Gly Leu Arg Ala 
            340                 345                 350         


Val Lys Asn Ala Ile Asp Asp Gly Cys Val Val Pro Gly Ala Gly Ala 
        355                 360                 365             


Val Glu Val Ala Met Ala Glu Ala Leu Ile Lys His Lys Pro Ser Val 
    370                 375                 380                 


Lys Gly Arg Ala Gln Leu Gly Val Gln Ala Phe Ala Asp Ala Leu Leu 
385                 390                 395                 400 


Ile Ile Pro Lys Val Leu Ala Gln Asn Ser Gly Phe Asp Leu Gln Glu 
                405                 410                 415     


Thr Leu Val Lys Ile Gln Ala Glu His Ser Glu Ser Gly Gln Leu Val 
            420                 425                 430         


Gly Val Asp Leu Asn Thr Gly Glu Pro Met Val Ala Ala Glu Val Gly 
        435                 440                 445             


Val Trp Asp Asn Tyr Cys Val Lys Lys Gln Leu Leu His Ser Cys Thr 
    450                 455                 460                 


Val Ile Ala Thr Asn Ile Leu Leu Val Asp Glu Ile Met Arg Ala Gly 
465                 470                 475                 480 


Met Ser Ser Leu Lys Gly 
                485     


<210>  1788
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCT6B__Homo_sapiens__NP_001180458

<400>  1788

Met Ala Ala Ile Lys Ala Val Asn Ser Lys Ala Glu Val Ala Arg Ala 
1               5                   10                  15      


Arg Ala Ala Leu Ala Val Asn Ile Cys Ala Ala Arg Gly Leu Gln Asp 
            20                  25                  30          


Val Leu Arg Thr Asn Leu Gly Pro Lys Gly Thr Met Lys Met Leu Val 
        35                  40                  45              


Ser Gly Ala Gly Asp Ile Lys Leu Thr Lys Asp Gly Asn Val Leu Leu 
    50                  55                  60                  


Asp Glu Met Gln Ile Gln His Pro Thr Ala Ser Leu Ile Ala Lys Val 
65                  70                  75                  80  


Ala Thr Ala Gln Asp Asp Val Thr Gly Asp Gly Thr Thr Ser Asn Val 
                85                  90                  95      


Leu Ile Ile Gly Glu Leu Leu Lys Gln Ala Asp Leu Tyr Ile Ser Glu 
            100                 105                 110         


Gly Leu His Pro Arg Ile Ile Ala Glu Gly Phe Glu Ala Ala Lys Ile 
        115                 120                 125             


Lys Ala Leu Glu Val Leu Glu Glu Val Lys Val Thr Lys Glu Met Lys 
    130                 135                 140                 


Arg Lys Ile Leu Leu Asp Val Ala Arg Thr Ser Leu Gln Thr Lys Val 
145                 150                 155                 160 


His Ala Glu Leu Ala Asp Val Leu Thr Glu Val Val Val Asp Ser Val 
                165                 170                 175     


Leu Ala Val Arg Arg Pro Gly Tyr Pro Ile Asp Leu Phe Met Val Glu 
            180                 185                 190         


Ile Met Glu Met Lys His Lys Leu Gly Thr Asp Thr Lys Glu Val Asn 
        195                 200                 205             


Ser Gly Phe Phe Tyr Lys Thr Ala Glu Glu Lys Glu Lys Leu Val Lys 
    210                 215                 220                 


Ala Glu Arg Lys Phe Ile Glu Asp Arg Val Gln Lys Ile Ile Asp Leu 
225                 230                 235                 240 


Lys Asp Lys Val Cys Ala Gln Ser Asn Lys Gly Phe Val Val Ile Asn 
                245                 250                 255     


Gln Lys Gly Ile Asp Pro Phe Ser Leu Asp Ser Leu Ala Lys His Gly 
            260                 265                 270         


Ile Val Ala Leu Arg Arg Ala Lys Arg Arg Asn Met Glu Arg Leu Ser 
        275                 280                 285             


Leu Ala Cys Gly Gly Met Ala Val Asn Ser Phe Glu Asp Leu Thr Val 
    290                 295                 300                 


Asp Cys Leu Gly His Ala Gly Leu Val Tyr Glu Tyr Thr Leu Gly Glu 
305                 310                 315                 320 


Glu Lys Phe Thr Phe Ile Glu Glu Cys Val Asn Pro Cys Ser Val Thr 
                325                 330                 335     


Leu Leu Val Lys Gly Pro Asn Lys His Thr Leu Thr Gln Val Lys Asp 
            340                 345                 350         


Ala Ile Arg Asp Gly Leu Arg Ala Ile Lys Asn Ala Ile Glu Asp Gly 
        355                 360                 365             


Cys Met Val Pro Gly Ala Gly Ala Ile Glu Val Ala Met Ala Glu Ala 
    370                 375                 380                 


Leu Val Thr Tyr Lys Asn Ser Ile Lys Gly Arg Ala Arg Leu Gly Val 
385                 390                 395                 400 


Gln Ala Phe Ala Asp Ala Leu Leu Ile Ile Pro Lys Val Leu Ala Gln 
                405                 410                 415     


Asn Ala Gly Tyr Asp Pro Gln Glu Thr Leu Val Lys Val Gln Ala Glu 
            420                 425                 430         


His Val Glu Ser Lys Gln Leu Val Gly Val Asp Leu Asn Thr Gly Glu 
        435                 440                 445             


Pro Met Val Ala Ala Asp Ala Gly Val Trp Asp Asn Tyr Cys Val Lys 
    450                 455                 460                 


Lys Gln Leu Leu His Ser Cys Thr Val Ile Ala Thr Asn Ile Leu Leu 
465                 470                 475                 480 


Val Asp Glu Ile Met Arg Ala Gly Met Ser Ser Leu Lys 
                485                 490             


<210>  1789
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCT7__Homo_sapiens__NP_001009570

<400>  1789

Met Met Asp Ser Gln Leu Val Ala Gly Val Ala Phe Lys Lys Thr Phe 
1               5                   10                  15      


Ser Tyr Ala Gly Phe Glu Met Gln Pro Lys Lys Tyr His Asn Pro Lys 
            20                  25                  30          


Ile Ala Leu Leu Asn Val Glu Leu Glu Leu Lys Ala Glu Lys Asp Asn 
        35                  40                  45              


Ala Glu Ile Arg Val His Thr Val Glu Asp Tyr Gln Ala Ile Val Asp 
    50                  55                  60                  


Ala Glu Trp Asn Ile Leu Tyr Asp Lys Leu Glu Lys Ile His His Ser 
65                  70                  75                  80  


Gly Ala Lys Val Val Leu Ser Lys Leu Pro Ile Gly Asp Val Ala Thr 
                85                  90                  95      


Gln Tyr Phe Ala Asp Arg Asp Met Phe Cys Ala Gly Arg Val Pro Glu 
            100                 105                 110         


Glu Asp Leu Lys Arg Thr Met Met Ala Cys Gly Gly Ser Ile Gln Thr 
        115                 120                 125             


Ser Val Asn Ala Leu Ser Ala Asp Val Leu Gly Arg Cys Gln Val Phe 
    130                 135                 140                 


Glu Glu Thr Gln Ile Gly Gly Glu Arg Tyr Asn Phe Phe Thr Gly Cys 
145                 150                 155                 160 


Pro Lys Ala Lys Thr Cys Thr Phe Ile Leu Arg Gly Gly Ala Glu Gln 
                165                 170                 175     


Phe Met Glu Glu Thr Glu Arg Ser Leu His Asp Ala Ile Met Ile Val 
            180                 185                 190         


Arg Arg Ala Ile Lys Asn Asp Ser Val Val Ala Gly Gly Gly Ala Ile 
        195                 200                 205             


Glu Met Glu Leu Ser Lys Tyr Leu Arg Asp Tyr Ser Arg Thr Ile Pro 
    210                 215                 220                 


Gly Lys Gln Gln Leu Leu Ile Gly Ala Tyr Ala Lys Ala Leu Glu Ile 
225                 230                 235                 240 


Ile Pro Arg Gln Leu Cys Asp Asn Ala Gly Phe Asp Ala Thr Asn Ile 
                245                 250                 255     


Leu Asn Lys Leu Arg Ala Arg His Ala Gln Gly Gly Thr Trp Tyr Gly 
            260                 265                 270         


Val Asp Ile Asn Asn Glu Asp Ile Ala Asp Asn Phe Glu Ala Phe Val 
        275                 280                 285             


Trp Glu Pro Ala Met Val Arg Ile Asn Ala Leu Thr Ala Ala Ser Glu 
    290                 295                 300                 


Ala Ala Cys Leu Ile Val Ser Val Asp Glu Thr Ile Lys Asn Pro Arg 
305                 310                 315                 320 


Ser Thr Val Asp Ala Pro Thr Ala Ala Gly Arg Gly Arg Gly Arg Gly 
                325                 330                 335     


Arg Pro His 
            


<210>  1790
<211>  1428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD109__Homo_sapiens__NP_001153059

<400>  1790

Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Thr Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Thr Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Thr Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Thr Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Thr Leu Thr Leu Pro Ser Leu Pro Leu Asn 
                85                  90                  95      


Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Thr Gly Arg Thr Gln Asp 
            100                 105                 110         


Glu Ile Leu Phe Ser Asn Ser Thr Arg Leu Ser Phe Glu Thr Lys Arg 
        115                 120                 125             


Ile Ser Val Phe Ile Gln Thr Asp Lys Ala Leu Tyr Lys Pro Lys Gln 
    130                 135                 140                 


Glu Val Lys Phe Arg Ile Val Thr Leu Phe Ser Asp Phe Lys Pro Tyr 
145                 150                 155                 160 


Lys Thr Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile 
                165                 170                 175     


Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Thr 
            180                 185                 190         


Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val 
        195                 200                 205             


Gln Val Asn Asp Gln Thr Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Thr Leu Gln Thr Pro Leu Tyr Cys Ser 
225                 230                 235                 240 


Met Asn Ser Lys His Leu Asn Gly Thr Ile Thr Ala Lys Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Lys Gly Asp Val Thr Leu Thr Phe Leu Pro Leu Ser 
            260                 265                 270         


Phe Trp Gly Lys Lys Lys Asn Ile Thr Lys Thr Phe Lys Ile Asn Gly 
        275                 280                 285             


Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp 
    290                 295                 300                 


Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro 
305                 310                 315                 320 


Val Glu Ile Leu Thr Thr Val Thr Glu Ser Val Thr Gly Ile Ser Arg 
                325                 330                 335     


Asn Val Ser Thr Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu 
            340                 345                 350         


Phe Phe Asp Tyr Thr Thr Val Leu Lys Pro Ser Leu Asn Phe Thr Ala 
        355                 360                 365             


Thr Val Lys Val Thr Arg Ala Asp Gly Asn Gln Leu Thr Leu Glu Glu 
    370                 375                 380                 


Arg Arg Asn Asn Val Val Ile Thr Val Thr Gln Arg Asn Tyr Thr Glu 
385                 390                 395                 400 


Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln 
                405                 410                 415     


Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys Ile Glu Phe 
            420                 425                 430         


Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu 
        435                 440                 445             


Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser 
    450                 455                 460                 


Lys Thr Tyr Ile Gln Leu Lys Thr Arg Asp Glu Asn Ile Lys Val Gly 
465                 470                 475                 480 


Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu 
                485                 490                 495     


Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln 
            500                 505                 510         


Asn Ser Thr Met Phe Ser Leu Thr Pro Glu Asn Ser Trp Thr Pro Lys 
        515                 520                 525             


Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser 
    530                 535                 540                 


Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys 
545                 550                 555                 560 


Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu 
                565                 570                 575     


Arg Ile Ser Val Thr Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val 
            580                 585                 590         


Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Thr Met Glu 
        595                 600                 605             


Asn Val Val His Glu Leu Glu Leu Tyr Asn Thr Gly Tyr Tyr Leu Gly 
    610                 615                 620                 


Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val 
625                 630                 635                 640 


Leu Thr Asp Ala Asn Leu Thr Lys Asp Tyr Ile Asp Gly Val Tyr Asp 
                645                 650                 655     


Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile 
            660                 665                 670         


Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys 
        675                 680                 685             


His Phe Pro Glu Thr Trp Ile Trp Leu Asp Thr Asn Met Gly Tyr Arg 
    690                 695                 700                 


Ile Tyr Gln Glu Phe Glu Val Thr Val Pro Asp Ser Ile Thr Ser Trp 
705                 710                 715                 720 


Val Ala Thr Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Thr 
                725                 730                 735     


Thr Thr Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu 
            740                 745                 750         


Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile 
        755                 760                 765             


Thr Ile Phe Asn Tyr Leu Lys Asp Ala Thr Glu Val Lys Val Ile Ile 
    770                 775                 780                 


Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Thr Ser Asn Glu Ile Asn 
785                 790                 795                 800 


Ala Thr Gly His Gln Gln Thr Leu Leu Val Pro Ser Glu Asp Gly Ala 
                805                 810                 815     


Thr Val Leu Phe Pro Ile Arg Pro Thr His Leu Gly Glu Ile Pro Ile 
            820                 825                 830         


Thr Val Thr Ala Leu Ser Pro Thr Ala Ser Asp Ala Val Thr Gln Met 
        835                 840                 845             


Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile 
    850                 855                 860                 


Leu Leu Asp Leu Thr Asp Asn Arg Leu Gln Ser Thr Leu Lys Thr Leu 
865                 870                 875                 880 


Ser Phe Ser Phe Pro Pro Asn Thr Val Thr Gly Ser Glu Arg Val Gln 
                885                 890                 895     


Ile Thr Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala 
            900                 905                 910         


Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn 
        915                 920                 925             


Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Thr Lys Lys Lys Gln 
    930                 935                 940                 


Leu Thr Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly 
945                 950                 955                 960 


Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala 
                965                 970                 975     


Phe Gly Asn Tyr Asp Pro Ser Gly Ser Thr Trp Leu Ser Ala Phe Val 
            980                 985                 990         


Leu Arg Cys Phe Leu Glu Ala Asp  Pro Tyr Ile Asp Ile  Asp Gln Asn 
        995                 1000                 1005             


Val Leu  His Arg Thr Tyr Thr  Trp Leu Lys Gly His  Gln Lys Ser 
    1010                 1015                 1020             


Asn Gly  Glu Phe Trp Asp Pro  Gly Arg Val Ile His  Ser Glu Leu 
    1025                 1030                 1035             


Gln Gly  Gly Asn Lys Ser Pro  Val Thr Leu Thr Ala  Tyr Ile Val 
    1040                 1045                 1050             


Thr Ser  Leu Leu Gly Tyr Arg  Lys Tyr Gln Pro Asn  Ile Asp Val 
    1055                 1060                 1065             


Gln Glu  Ser Ile His Phe Leu  Glu Ser Glu Phe Ser  Arg Gly Ile 
    1070                 1075                 1080             


Ser Asp  Asn Tyr Thr Leu Ala  Leu Ile Thr Tyr Ala  Leu Ser Ser 
    1085                 1090                 1095             


Val Gly  Ser Pro Lys Ala Lys  Glu Ala Leu Asn Met  Leu Thr Trp 
    1100                 1105                 1110             


Arg Ala  Glu Gln Glu Gly Gly  Met Gln Phe Trp Val  Ser Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Ser Asp Ser Trp  Gln Pro Arg Ser Leu  Asp Ile Glu 
    1130                 1135                 1140             


Val Ala  Ala Tyr Ala Leu Leu  Ser His Phe Leu Gln  Phe Gln Thr 
    1145                 1150                 1155             


Ser Glu  Gly Ile Pro Ile Met  Arg Trp Leu Ser Arg  Gln Arg Asn 
    1160                 1165                 1170             


Ser Leu  Gly Gly Phe Ala Ser  Thr Gln Asp Thr Thr  Val Ala Leu 
    1175                 1180                 1185             


Lys Ala  Leu Ser Glu Phe Ala  Ala Leu Met Asn Thr  Glu Arg Thr 
    1190                 1195                 1200             


Asn Ile  Gln Val Thr Val Thr  Gly Pro Ser Ser Pro  Ser Pro Leu 
    1205                 1210                 1215             


Ala Val  Val Gln Pro Thr Ala  Val Asn Ile Ser Ala  Asn Gly Phe 
    1220                 1225                 1230             


Gly Phe  Ala Ile Cys Gln Leu  Asn Val Val Tyr Asn  Val Lys Ala 
    1235                 1240                 1245             


Ser Gly  Ser Ser Arg Arg Arg  Arg Ser Ile Gln Asn  Gln Glu Ala 
    1250                 1255                 1260             


Phe Asp  Leu Asp Val Ala Val  Lys Glu Asn Lys Asp  Asp Leu Asn 
    1265                 1270                 1275             


His Val  Asp Leu Asn Val Cys  Thr Ser Phe Ser Gly  Pro Gly Arg 
    1280                 1285                 1290             


Ser Gly  Met Ala Leu Met Glu  Val Asn Leu Leu Ser  Gly Phe Met 
    1295                 1300                 1305             


Val Pro  Ser Glu Ala Ile Ser  Leu Ser Glu Thr Val  Lys Lys Val 
    1310                 1315                 1320             


Glu Tyr  Asp His Gly Lys Leu  Asn Leu Tyr Leu Asp  Ser Val Asn 
    1325                 1330                 1335             


Glu Thr  Gln Phe Cys Val Asn  Ile Pro Ala Val Arg  Asn Phe Lys 
    1340                 1345                 1350             


Val Ser  Asn Thr Gln Asp Ala  Ser Val Ser Ile Val  Asp Tyr Tyr 
    1355                 1360                 1365             


Glu Pro  Arg Arg Gln Ala Val  Arg Ser Tyr Asn Ser  Glu Val Lys 
    1370                 1375                 1380             


Leu Ser  Ser Cys Asp Leu Cys  Ser Asp Val Gln Gly  Cys Arg Pro 
    1385                 1390                 1395             


Cys Glu  Asp Gly Ala Ser Gly  Ser His His His Ser  Ser Val Ile 
    1400                 1405                 1410             


Phe Ile  Phe Cys Phe Lys Leu  Leu Tyr Phe Met Glu  Leu Trp Leu 
    1415                 1420                 1425             


<210>  1791
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD14__Homo_sapiens__NP_001167576

<400>  1791

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  1792
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD151__Homo_sapiens__NP_001034579

<400>  1792

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  1793
<211>  1156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD163__Homo_sapiens__NP_004235

<400>  1793

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  1794
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD163L1__Homo_sapiens__NP_777601

<400>  1794

Met Met Leu Pro Gln Asn Ser Trp His Ile Asp Phe Gly Arg Cys Cys 
1               5                   10                  15      


Cys His Gln Asn Leu Phe Ser Ala Val Val Thr Cys Ile Leu Leu Leu 
            20                  25                  30          


Asn Ser Cys Phe Leu Ile Ser Ser Phe Asn Gly Thr Asp Leu Glu Leu 
        35                  40                  45              


Arg Leu Val Asn Gly Asp Gly Pro Cys Ser Gly Thr Val Glu Val Lys 
    50                  55                  60                  


Phe Gln Gly Gln Trp Gly Thr Val Cys Asp Asp Gly Trp Asn Thr Thr 
65                  70                  75                  80  


Ala Ser Thr Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Phe Ala 
                85                  90                  95      


Met Phe Arg Phe Gly Gln Ala Val Thr Arg His Gly Lys Ile Trp Leu 
            100                 105                 110         


Asp Asp Val Ser Cys Tyr Gly Asn Glu Ser Ala Leu Trp Glu Cys Gln 
        115                 120                 125             


His Arg Glu Trp Gly Ser His Asn Cys Tyr His Gly Glu Asp Val Gly 
    130                 135                 140                 


Val Asn Cys Tyr Gly Glu Ala Asn Leu Gly Leu Arg Leu Val Asp Gly 
145                 150                 155                 160 


Asn Asn Ser Cys Ser Gly Arg Val Glu Val Lys Phe Gln Glu Arg Trp 
                165                 170                 175     


Gly Thr Ile Cys Asp Asp Gly Trp Asn Leu Asn Thr Ala Ala Val Val 
            180                 185                 190         


Cys Arg Gln Leu Gly Cys Pro Ser Ser Phe Ile Ser Ser Gly Val Val 
        195                 200                 205             


Asn Ser Pro Ala Val Leu Arg Pro Ile Trp Leu Asp Asp Ile Leu Cys 
    210                 215                 220                 


Gln Gly Asn Glu Leu Ala Leu Trp Asn Cys Arg His Arg Gly Trp Gly 
225                 230                 235                 240 


Asn His Asp Cys Ser His Asn Glu Asp Val Thr Leu Thr Cys Tyr Asp 
                245                 250                 255     


Ser Ser Asp Leu Glu Leu Arg Leu Val Gly Gly Thr Asn Arg Cys Met 
            260                 265                 270         


Gly Arg Val Glu Leu Lys Ile Gln Gly Arg Trp Gly Thr Val Cys His 
        275                 280                 285             


His Lys Trp Asn Asn Ala Ala Ala Asp Val Val Cys Lys Gln Leu Gly 
    290                 295                 300                 


Cys Gly Thr Ala Leu His Phe Ala Gly Leu Pro His Leu Gln Ser Gly 
305                 310                 315                 320 


Ser Asp Val Val Trp Leu Asp Gly Val Ser Cys Ser Gly Asn Glu Ser 
                325                 330                 335     


Phe Leu Trp Asp Cys Arg His Ser Gly Thr Val Asn Phe Asp Cys Leu 
            340                 345                 350         


His Gln Asn Asp Val Ser Val Ile Cys Ser Asp Gly Ala Asp Leu Glu 
        355                 360                 365             


Leu Arg Leu Ala Asp Gly Ser Asn Asn Cys Ser Gly Arg Val Glu Val 
    370                 375                 380                 


Arg Ile His Glu Gln Trp Trp Thr Ile Cys Asp Gln Asn Trp Lys Asn 
385                 390                 395                 400 


Glu Gln Ala Leu Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Val 
                405                 410                 415     


Phe Gly Ser Arg Arg Ala Lys Pro Ser Asn Glu Ala Arg Asp Ile Trp 
            420                 425                 430         


Ile Asn Ser Ile Ser Cys Thr Gly Asn Glu Ser Ala Leu Trp Asp Cys 
        435                 440                 445             


Thr Tyr Asp Gly Lys Ala Lys Arg Thr Cys Phe Arg Arg Ser Asp Ala 
    450                 455                 460                 


Gly Val Ile Cys Ser Asp Lys Ala Asp Leu Asp Leu Arg Leu Val Gly 
465                 470                 475                 480 


Ala His Ser Pro Cys Tyr Gly Arg Leu Glu Val Lys Tyr Gln Gly Glu 
                485                 490                 495     


Trp Gly Thr Val Cys His Asp Arg Trp Ser Thr Arg Asn Ala Ala Val 
            500                 505                 510         


Val Cys Lys Gln Leu Gly Cys Gly Lys Pro Met His Val Phe Gly Met 
        515                 520                 525             


Thr Tyr Phe Lys Glu Ala Ser Gly Pro Ile Trp Leu Asp Asp Val Ser 
    530                 535                 540                 


Cys Ile Gly Asn Glu Ser Asn Ile Trp Asp Cys Glu His Ser Gly Trp 
545                 550                 555                 560 


Gly Lys His Asn Cys Val His Arg Glu Asp Val Ile Val Thr Cys Ser 
                565                 570                 575     


Gly Asp Ala Thr Trp Gly Leu Arg Leu Val Gly Gly Ser Asn Arg Cys 
            580                 585                 590         


Ser Gly Arg Leu Glu Val Tyr Phe Gln Gly Arg Trp Gly Thr Val Cys 
        595                 600                 605             


Asp Asp Gly Trp Asn Ser Lys Ala Ala Ala Val Val Cys Ser Gln Leu 
    610                 615                 620                 


Asp Cys Pro Ser Ser Ile Ile Gly Met Gly Leu Gly Asn Ala Ser Thr 
625                 630                 635                 640 


Gly Tyr Gly Lys Ile Trp Leu Asp Asp Val Ser Cys Asp Gly Asp Glu 
                645                 650                 655     


Ser Asp Leu Trp Ser Cys Arg Asn Ser Gly Trp Gly Asn Asn Asp Cys 
            660                 665                 670         


Ser His Ser Glu Asp Val Gly Val Ile Cys Ser Asp Ala Ser Asp Met 
        675                 680                 685             


Glu Leu Arg Leu Val Gly Gly Ser Ser Arg Cys Ala Gly Lys Val Glu 
    690                 695                 700                 


Val Asn Val Gln Gly Ala Val Gly Ile Leu Cys Ala Asn Gly Trp Gly 
705                 710                 715                 720 


Met Asn Ile Ala Glu Val Val Cys Arg Gln Leu Glu Cys Gly Ser Ala 
                725                 730                 735     


Ile Arg Val Ser Arg Glu Pro His Phe Thr Glu Arg Thr Leu His Ile 
            740                 745                 750         


Leu Met Ser Asn Ser Gly Cys Thr Gly Gly Glu Ala Ser Leu Trp Asp 
        755                 760                 765             


Cys Ile Arg Trp Glu Trp Lys Gln Thr Ala Cys His Leu Asn Met Glu 
    770                 775                 780                 


Ala Ser Leu Ile Cys Ser Ala His Arg Gln Pro Arg Leu Val Gly Ala 
785                 790                 795                 800 


Asp Met Pro Cys Ser Gly Arg Val Glu Val Lys His Ala Asp Thr Trp 
                805                 810                 815     


Arg Ser Val Cys Asp Ser Asp Phe Ser Leu His Ala Ala Asn Val Leu 
            820                 825                 830         


Cys Arg Glu Leu Asn Cys Gly Asp Ala Ile Ser Leu Ser Val Gly Asp 
        835                 840                 845             


His Phe Gly Lys Gly Asn Gly Leu Thr Trp Ala Glu Lys Phe Gln Cys 
    850                 855                 860                 


Glu Gly Ser Glu Thr His Leu Ala Leu Cys Pro Ile Val Gln His Pro 
865                 870                 875                 880 


Glu Asp Thr Cys Ile His Ser Arg Glu Val Gly Val Val Cys Ser Arg 
                885                 890                 895     


Tyr Thr Asp Val Arg Leu Val Asn Gly Lys Ser Gln Cys Asp Gly Gln 
            900                 905                 910         


Val Glu Ile Asn Val Leu Gly His Trp Gly Ser Leu Cys Asp Thr His 
        915                 920                 925             


Trp Asp Pro Glu Asp Ala Arg Val Leu Cys Arg Gln Leu Ser Cys Gly 
    930                 935                 940                 


Thr Ala Leu Ser Thr Thr Gly Gly Lys Tyr Ile Gly Glu Arg Ser Val 
945                 950                 955                 960 


Arg Val Trp Gly His Arg Phe His Cys Leu Gly Asn Glu Ser Leu Leu 
                965                 970                 975     


Asp Asn Cys Gln Met Thr Val Leu Gly Ala Pro Pro Cys Ile His Gly 
            980                 985                 990         


Asn Thr Val Ser Val Ile Cys Thr  Gly Ser Leu Thr Gln  Pro Leu Phe 
        995                 1000                 1005             


Pro Cys  Leu Ala Asn Val Ser  Asp Pro Tyr Leu Ser  Ala Val Pro 
    1010                 1015                 1020             


Glu Gly  Ser Ala Leu Ile Cys  Leu Glu Asp Lys Arg  Leu Arg Leu 
    1025                 1030                 1035             


Val Asp  Gly Asp Ser Arg Cys  Ala Gly Arg Val Glu  Ile Tyr His 
    1040                 1045                 1050             


Asp Gly  Phe Trp Gly Thr Ile  Cys Asp Asp Gly Trp  Asp Leu Ser 
    1055                 1060                 1065             


Asp Ala  His Val Val Cys Gln  Lys Leu Gly Cys Gly  Val Ala Phe 
    1070                 1075                 1080             


Asn Ala  Thr Val Ser Ala His  Phe Gly Glu Gly Ser  Gly Pro Ile 
    1085                 1090                 1095             


Trp Leu  Asp Asp Leu Asn Cys  Thr Gly Met Glu Ser  His Leu Trp 
    1100                 1105                 1110             


Gln Cys  Pro Ser Arg Gly Trp  Gly Gln His Asp Cys  Arg His Lys 
    1115                 1120                 1125             


Glu Asp  Ala Gly Val Ile Cys  Ser Glu Phe Thr Ala  Leu Arg Leu 
    1130                 1135                 1140             


Tyr Ser  Glu Thr Glu Thr Glu  Ser Cys Ala Gly Arg  Leu Glu Val 
    1145                 1150                 1155             


Phe Tyr  Asn Gly Thr Trp Gly  Ser Val Gly Arg Arg  Asn Ile Thr 
    1160                 1165                 1170             


Thr Ala  Ile Ala Gly Ile Val  Cys Arg Gln Leu Gly  Cys Gly Glu 
    1175                 1180                 1185             


Asn Gly  Val Val Ser Leu Ala  Pro Leu Ser Lys Thr  Gly Ser Gly 
    1190                 1195                 1200             


Phe Met  Trp Val Asp Asp Ile  Gln Cys Pro Lys Thr  His Ile Ser 
    1205                 1210                 1215             


Ile Trp  Gln Cys Leu Ser Ala  Pro Trp Glu Arg Arg  Ile Ser Ser 
    1220                 1225                 1230             


Pro Ala  Glu Glu Thr Trp Ile  Thr Cys Glu Asp Arg  Ile Arg Val 
    1235                 1240                 1245             


Arg Gly  Gly Asp Thr Glu Cys  Ser Gly Arg Val Glu  Ile Trp His 
    1250                 1255                 1260             


Ala Gly  Ser Trp Gly Thr Val  Cys Asp Asp Ser Trp  Asp Leu Ala 
    1265                 1270                 1275             


Glu Ala  Glu Val Val Cys Gln  Gln Leu Gly Cys Gly  Ser Ala Leu 
    1280                 1285                 1290             


Ala Ala  Leu Arg Asp Ala Ser  Phe Gly Gln Gly Thr  Gly Thr Ile 
    1295                 1300                 1305             


Trp Leu  Asp Asp Met Arg Cys  Lys Gly Asn Glu Ser  Phe Leu Trp 
    1310                 1315                 1320             


Asp Cys  His Ala Lys Pro Trp  Gly Gln Ser Asp Cys  Gly His Lys 
    1325                 1330                 1335             


Glu Asp  Ala Gly Val Arg Cys  Ser Gly Gln Ser Leu  Lys Ser Leu 
    1340                 1345                 1350             


Asn Ala  Ser Ser Gly His Leu  Ala Leu Ile Leu Ser  Ser Ile Phe 
    1355                 1360                 1365             


Gly Leu  Leu Leu Leu Val Leu  Phe Ile Leu Phe Leu  Thr Trp Cys 
    1370                 1375                 1380             


Arg Val  Gln Lys Gln Lys His  Leu Pro Leu Arg Val  Ser Thr Arg 
    1385                 1390                 1395             


Arg Arg  Gly Ser Leu Glu Glu  Asn Leu Phe His Glu  Met Glu Thr 
    1400                 1405                 1410             


Cys Leu  Lys Arg Glu Asp Pro  His Gly Thr Arg Thr  Ser Asp Asp 
    1415                 1420                 1425             


Thr Pro  Asn His Gly Cys Glu  Asp Ala Ser Asp Thr  Ser Leu Leu 
    1430                 1435                 1440             


Gly Val  Leu Pro Ala Ser Glu  Ala Thr Lys 
    1445                 1450             


<210>  1795
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD164__Homo_sapiens__NP_001135873

<400>  1795

Met Ser Arg Leu Ser Arg Ser Leu Leu Trp Ala Ala Thr Cys Leu Gly 
1               5                   10                  15      


Val Leu Cys Val Leu Ser Ala Asp Lys Asn Thr Thr Gln His Pro Asn 
            20                  25                  30          


Val Thr Thr Leu Ala Pro Ile Ser Asn Val Thr Ser Ala Pro Val Thr 
        35                  40                  45              


Ser Leu Pro Leu Val Thr Thr Pro Ala Pro Glu Thr Cys Glu Gly Arg 
    50                  55                  60                  


Asn Ser Cys Val Ser Cys Phe Asn Val Ser Val Val Asn Thr Thr Cys 
65                  70                  75                  80  


Phe Trp Ile Glu Cys Lys Asp Glu Ser Tyr Cys Ser His Asn Ser Thr 
                85                  90                  95      


Val Ser Asp Cys Gln Val Gly Asn Thr Thr Asp Phe Cys Ser Ala Lys 
            100                 105                 110         


Pro Thr Val Gln Pro Ser Pro Ser Thr Thr Ser Lys Thr Val Thr Thr 
        115                 120                 125             


Ser Gly Thr Thr Asn Asn Thr Val Thr Pro Thr Ser Gln Pro Val Arg 
    130                 135                 140                 


Lys Ser Thr Phe Asp Ala Ala Ser Phe Ile Gly Gly Ile Val Leu Val 
145                 150                 155                 160 


Leu Gly Val Gln Ala Val Ile Phe Phe Leu Tyr Lys Phe Cys Lys Ser 
                165                 170                 175     


Lys Glu Arg Asn Tyr His Thr Leu 
            180                 


<210>  1796
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD177__Homo_sapiens__NP_065139

<400>  1796

Met Ser Ala Val Leu Leu Leu Ala Leu Leu Gly Phe Ile Leu Pro Leu 
1               5                   10                  15      


Pro Gly Val Gln Ala Leu Leu Cys Gln Phe Gly Thr Val Gln His Val 
            20                  25                  30          


Trp Lys Val Ser Asp Leu Pro Arg Gln Trp Thr Pro Lys Asn Thr Ser 
        35                  40                  45              


Cys Asp Ser Gly Leu Gly Cys Gln Asp Thr Leu Met Leu Ile Glu Ser 
    50                  55                  60                  


Gly Pro Gln Val Ser Leu Val Leu Ser Lys Gly Cys Thr Glu Ala Lys 
65                  70                  75                  80  


Asp Gln Glu Pro Arg Val Thr Glu His Arg Met Gly Pro Gly Leu Ser 
                85                  90                  95      


Leu Ile Ser Tyr Thr Phe Val Cys Arg Gln Glu Asp Phe Cys Asn Asn 
            100                 105                 110         


Leu Val Asn Ser Leu Pro Leu Trp Ala Pro Gln Pro Pro Ala Asp Pro 
        115                 120                 125             


Gly Ser Leu Arg Cys Pro Val Cys Leu Ser Met Glu Gly Cys Leu Glu 
    130                 135                 140                 


Gly Thr Thr Glu Glu Ile Cys Pro Lys Gly Thr Thr His Cys Tyr Asp 
145                 150                 155                 160 


Gly Leu Leu Arg Leu Arg Gly Gly Gly Ile Phe Ser Asn Leu Arg Val 
                165                 170                 175     


Gln Gly Cys Met Pro Gln Pro Val Cys Asn Leu Leu Asn Gly Thr Gln 
            180                 185                 190         


Glu Ile Gly Pro Val Gly Met Thr Glu Asn Cys Asp Met Lys Asp Phe 
        195                 200                 205             


Leu Thr Cys His Arg Gly Thr Thr Ile Met Thr His Gly Asn Leu Ala 
    210                 215                 220                 


Gln Glu Pro Thr Asp Trp Thr Thr Ser Asn Thr Glu Met Cys Glu Val 
225                 230                 235                 240 


Gly Gln Val Cys Gln Glu Thr Leu Leu Leu Leu Asp Val Gly Leu Thr 
                245                 250                 255     


Ser Thr Leu Val Gly Thr Lys Gly Cys Ser Thr Val Gly Ala Gln Asn 
            260                 265                 270         


Ser Gln Lys Thr Thr Ile His Ser Ala Pro Pro Gly Val Leu Val Ala 
        275                 280                 285             


Ser Tyr Thr His Phe Cys Ser Ser Asp Leu Cys Asn Ser Ala Ser Ser 
    290                 295                 300                 


Ser Ser Val Leu Leu Asn Ser Leu Pro Pro Gln Ala Ala Pro Val Pro 
305                 310                 315                 320 


Gly Asp Arg Gln Cys Pro Thr Cys Val Gln Pro Leu Gly Thr Cys Ser 
                325                 330                 335     


Ser Gly Ser Pro Arg Met Thr Cys Pro Arg Gly Ala Thr His Cys Tyr 
            340                 345                 350         


Asp Gly Tyr Ile His Leu Ser Gly Gly Gly Leu Ser Thr Lys Met Ser 
        355                 360                 365             


Ile Gln Gly Cys Val Ala Gln Pro Ser Ser Phe Leu Leu Asn His Thr 
    370                 375                 380                 


Arg Gln Ile Gly Ile Phe Ser Ala Arg Glu Lys Arg Asp Val Gln Pro 
385                 390                 395                 400 


Pro Ala Ser Gln His Glu Gly Gly Gly Ala Glu Gly Leu Glu Ser Leu 
                405                 410                 415     


Thr Trp Gly Val Gly Leu Ala Leu Ala Pro Ala Leu Trp Trp Gly Val 
            420                 425                 430         


Val Cys Pro Ser Cys 
        435         


<210>  1797
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD180__Homo_sapiens__NP_005573

<400>  1797

Met Ala Phe Asp Val Ser Cys Phe Phe Trp Val Val Leu Phe Ser Ala 
1               5                   10                  15      


Gly Cys Lys Val Ile Thr Ser Trp Asp Gln Met Cys Ile Glu Lys Glu 
            20                  25                  30          


Ala Asn Lys Thr Tyr Asn Cys Glu Asn Leu Gly Leu Ser Glu Ile Pro 
        35                  40                  45              


Asp Thr Leu Pro Asn Thr Thr Glu Phe Leu Glu Phe Ser Phe Asn Phe 
    50                  55                  60                  


Leu Pro Thr Ile His Asn Arg Thr Phe Ser Arg Leu Met Asn Leu Thr 
65                  70                  75                  80  


Phe Leu Asp Leu Thr Arg Cys Gln Ile Asn Trp Ile His Glu Asp Thr 
                85                  90                  95      


Phe Gln Ser His His Gln Leu Ser Thr Leu Val Leu Thr Gly Asn Pro 
            100                 105                 110         


Leu Ile Phe Met Ala Glu Thr Ser Leu Asn Gly Pro Lys Ser Leu Lys 
        115                 120                 125             


His Leu Phe Leu Ile Gln Thr Gly Ile Ser Asn Leu Glu Phe Ile Pro 
    130                 135                 140                 


Val His Asn Leu Glu Asn Leu Glu Ser Leu Tyr Leu Gly Ser Asn His 
145                 150                 155                 160 


Ile Ser Ser Ile Lys Phe Pro Lys Asp Phe Pro Ala Arg Asn Leu Lys 
                165                 170                 175     


Val Leu Asp Phe Gln Asn Asn Ala Ile His Tyr Ile Ser Arg Glu Asp 
            180                 185                 190         


Met Arg Ser Leu Glu Gln Ala Ile Asn Leu Ser Leu Asn Phe Asn Gly 
        195                 200                 205             


Asn Asn Val Lys Gly Ile Glu Leu Gly Ala Phe Asp Ser Thr Ile Phe 
    210                 215                 220                 


Gln Ser Leu Asn Phe Gly Gly Thr Pro Asn Leu Ser Val Ile Phe Asn 
225                 230                 235                 240 


Gly Leu Gln Asn Ser Thr Thr Gln Ser Leu Trp Leu Gly Thr Phe Glu 
                245                 250                 255     


Asp Ile Asp Asp Glu Asp Ile Ser Ser Ala Met Leu Lys Gly Leu Cys 
            260                 265                 270         


Glu Met Ser Val Glu Ser Leu Asn Leu Gln Glu His Arg Phe Ser Asp 
        275                 280                 285             


Ile Ser Ser Thr Thr Phe Gln Cys Phe Thr Gln Leu Gln Glu Leu Asp 
    290                 295                 300                 


Leu Thr Ala Thr His Leu Lys Gly Leu Pro Ser Gly Met Lys Gly Leu 
305                 310                 315                 320 


Asn Leu Leu Lys Lys Leu Val Leu Ser Val Asn His Phe Asp Gln Leu 
                325                 330                 335     


Cys Gln Ile Ser Ala Ala Asn Phe Pro Ser Leu Thr His Leu Tyr Ile 
            340                 345                 350         


Arg Gly Asn Val Lys Lys Leu His Leu Gly Val Gly Cys Leu Glu Lys 
        355                 360                 365             


Leu Gly Asn Leu Gln Thr Leu Asp Leu Ser His Asn Asp Ile Glu Ala 
    370                 375                 380                 


Ser Asp Cys Cys Ser Leu Gln Leu Lys Asn Leu Ser His Leu Gln Thr 
385                 390                 395                 400 


Leu Asn Leu Ser His Asn Glu Pro Leu Gly Leu Gln Ser Gln Ala Phe 
                405                 410                 415     


Lys Glu Cys Pro Gln Leu Glu Leu Leu Asp Leu Ala Phe Thr Arg Leu 
            420                 425                 430         


His Ile Asn Ala Pro Gln Ser Pro Phe Gln Asn Leu His Phe Leu Gln 
        435                 440                 445             


Val Leu Asn Leu Thr Tyr Cys Phe Leu Asp Thr Ser Asn Gln His Leu 
    450                 455                 460                 


Leu Ala Gly Leu Pro Val Leu Arg His Leu Asn Leu Lys Gly Asn His 
465                 470                 475                 480 


Phe Gln Asp Gly Thr Ile Thr Lys Thr Asn Leu Leu Gln Thr Val Gly 
                485                 490                 495     


Ser Leu Glu Val Leu Ile Leu Ser Ser Cys Gly Leu Leu Ser Ile Asp 
            500                 505                 510         


Gln Gln Ala Phe His Ser Leu Gly Lys Met Ser His Val Asp Leu Ser 
        515                 520                 525             


His Asn Ser Leu Thr Cys Asp Ser Ile Asp Ser Leu Ser His Leu Lys 
    530                 535                 540                 


Gly Ile Tyr Leu Asn Leu Ala Ala Asn Ser Ile Asn Ile Ile Ser Pro 
545                 550                 555                 560 


Arg Leu Leu Pro Ile Leu Ser Gln Gln Ser Thr Ile Asn Leu Ser His 
                565                 570                 575     


Asn Pro Leu Asp Cys Thr Cys Ser Asn Ile His Phe Leu Thr Trp Tyr 
            580                 585                 590         


Lys Glu Asn Leu His Lys Leu Glu Gly Ser Glu Glu Thr Thr Cys Ala 
        595                 600                 605             


Asn Pro Pro Ser Leu Arg Gly Val Lys Leu Ser Asp Val Lys Leu Ser 
    610                 615                 620                 


Cys Gly Ile Thr Ala Ile Gly Ile Phe Phe Leu Ile Val Phe Leu Leu 
625                 630                 635                 640 


Leu Leu Ala Ile Leu Leu Phe Phe Ala Val Lys Tyr Leu Leu Arg Trp 
                645                 650                 655     


Lys Tyr Gln His Ile 
            660     


<210>  1798
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19__Homo_sapiens__NP_001171569

<400>  1798

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Ala 
                485                 490                 495     


Gly Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro 
            500                 505                 510         


Gln Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp 
        515                 520                 525             


Ala Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala 
    530                 535                 540                 


Trp Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555         


<210>  1799
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD1A__Homo_sapiens__NP_001754

<400>  1799

Met Leu Phe Leu Leu Leu Pro Leu Leu Ala Val Leu Pro Gly Asp Gly 
1               5                   10                  15      


Asn Ala Asp Gly Leu Lys Glu Pro Leu Ser Phe His Val Thr Trp Ile 
            20                  25                  30          


Ala Ser Phe Tyr Asn His Ser Trp Lys Gln Asn Leu Val Ser Gly Trp 
        35                  40                  45              


Leu Ser Asp Leu Gln Thr His Thr Trp Asp Ser Asn Ser Ser Thr Ile 
    50                  55                  60                  


Val Phe Leu Cys Pro Trp Ser Arg Gly Asn Phe Ser Asn Glu Glu Trp 
65                  70                  75                  80  


Lys Glu Leu Glu Thr Leu Phe Arg Ile Arg Thr Ile Arg Ser Phe Glu 
                85                  90                  95      


Gly Ile Arg Arg Tyr Ala His Glu Leu Gln Phe Glu Tyr Pro Phe Glu 
            100                 105                 110         


Ile Gln Val Thr Gly Gly Cys Glu Leu His Ser Gly Lys Val Ser Gly 
        115                 120                 125             


Ser Phe Leu Gln Leu Ala Tyr Gln Gly Ser Asp Phe Val Ser Phe Gln 
    130                 135                 140                 


Asn Asn Ser Trp Leu Pro Tyr Pro Val Ala Gly Asn Met Ala Lys His 
145                 150                 155                 160 


Phe Cys Lys Val Leu Asn Gln Asn Gln His Glu Asn Asp Ile Thr His 
                165                 170                 175     


Asn Leu Leu Ser Asp Thr Cys Pro Arg Phe Ile Leu Gly Leu Leu Asp 
            180                 185                 190         


Ala Gly Lys Ala His Leu Gln Arg Gln Val Lys Pro Glu Ala Trp Leu 
        195                 200                 205             


Ser His Gly Pro Ser Pro Gly Pro Gly His Leu Gln Leu Val Cys His 
    210                 215                 220                 


Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg Gly 
225                 230                 235                 240 


Glu Gln Glu Gln Gln Gly Thr Gln Arg Gly Asp Ile Leu Pro Ser Ala 
                245                 250                 255     


Asp Gly Thr Trp Tyr Leu Arg Ala Thr Leu Glu Val Ala Ala Gly Glu 
            260                 265                 270         


Ala Ala Asp Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly Gln 
        275                 280                 285             


Asp Ile Val Leu Tyr Trp Glu His His Ser Ser Val Gly Phe Ile Ile 
    290                 295                 300                 


Leu Ala Val Ile Val Pro Leu Leu Leu Leu Ile Gly Leu Ala Leu Trp 
305                 310                 315                 320 


Phe Arg Lys Arg Cys Phe Cys 
                325         


<210>  1800
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD1B__Homo_sapiens__NP_001755

<400>  1800

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser Glu His Ala Phe Gln Gly Pro Thr Ser Phe His Val Ile Gln 
            20                  25                  30          


Thr Ser Ser Phe Thr Asn Ser Thr Trp Ala Gln Thr Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Asp Leu Gln Ile His Gly Trp Asp Ser Asp Ser Gly Thr 
    50                  55                  60                  


Ala Ile Phe Leu Lys Pro Trp Ser Lys Gly Asn Phe Ser Asp Lys Glu 
65                  70                  75                  80  


Val Ala Glu Leu Glu Glu Ile Phe Arg Val Tyr Ile Phe Gly Phe Ala 
                85                  90                  95      


Arg Glu Val Gln Asp Phe Ala Gly Asp Phe Gln Met Lys Tyr Pro Phe 
            100                 105                 110         


Glu Ile Gln Gly Ile Ala Gly Cys Glu Leu His Ser Gly Gly Ala Ile 
        115                 120                 125             


Val Ser Phe Leu Arg Gly Ala Leu Gly Gly Leu Asp Phe Leu Ser Val 
    130                 135                 140                 


Lys Asn Ala Ser Cys Val Pro Ser Pro Glu Gly Gly Ser Arg Ala Gln 
145                 150                 155                 160 


Lys Phe Cys Ala Leu Ile Ile Gln Tyr Gln Gly Ile Met Glu Thr Val 
                165                 170                 175     


Arg Ile Leu Leu Tyr Glu Thr Cys Pro Arg Tyr Leu Leu Gly Val Leu 
            180                 185                 190         


Asn Ala Gly Lys Ala Asp Leu Gln Arg Gln Val Lys Pro Glu Ala Trp 
        195                 200                 205             


Leu Ser Ser Gly Pro Ser Pro Gly Pro Gly Arg Leu Gln Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Met Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Leu Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asn Trp Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Ala Asp Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Ile Leu Tyr Trp Arg Asn Pro Thr Ser Ile Gly Ser Ile 
    290                 295                 300                 


Val Leu Ala Ile Ile Val Pro Ser Leu Leu Leu Leu Leu Cys Leu Ala 
305                 310                 315                 320 


Leu Trp Tyr Met Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
                325                 330             


<210>  1801
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD1C__Homo_sapiens__NP_001756

<400>  1801

Met Leu Phe Leu Gln Phe Leu Leu Leu Ala Leu Leu Leu Pro Gly Gly 
1               5                   10                  15      


Asp Asn Ala Asp Ala Ser Gln Glu His Val Ser Phe His Val Ile Gln 
            20                  25                  30          


Ile Phe Ser Phe Val Asn Gln Ser Trp Ala Arg Gly Gln Gly Ser Gly 
        35                  40                  45              


Trp Leu Asp Glu Leu Gln Thr His Gly Trp Asp Ser Glu Ser Gly Thr 
    50                  55                  60                  


Ile Ile Phe Leu His Asn Trp Ser Lys Gly Asn Phe Ser Asn Glu Glu 
65                  70                  75                  80  


Leu Ser Asp Leu Glu Leu Leu Phe Arg Phe Tyr Leu Phe Gly Leu Thr 
                85                  90                  95      


Arg Glu Ile Gln Asp His Ala Ser Gln Asp Tyr Ser Lys Tyr Pro Phe 
            100                 105                 110         


Glu Val Gln Val Lys Ala Gly Cys Glu Leu His Ser Gly Lys Ser Pro 
        115                 120                 125             


Glu Gly Phe Phe Gln Val Ala Phe Asn Gly Leu Asp Leu Leu Ser Phe 
    130                 135                 140                 


Gln Asn Thr Thr Trp Val Pro Ser Pro Gly Cys Gly Ser Leu Ala Gln 
145                 150                 155                 160 


Ser Val Cys His Leu Leu Asn His Gln Tyr Glu Gly Val Thr Glu Thr 
                165                 170                 175     


Val Tyr Asn Leu Ile Arg Ser Thr Cys Pro Arg Phe Leu Leu Gly Leu 
            180                 185                 190         


Leu Asp Ala Gly Lys Met Tyr Val His Arg Gln Val Arg Pro Glu Ala 
        195                 200                 205             


Trp Leu Ser Ser Arg Pro Ser Leu Gly Ser Gly Gln Leu Leu Leu Val 
    210                 215                 220                 


Cys His Ala Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Thr Trp Met 
225                 230                 235                 240 


Arg Asn Glu Gln Glu Gln Leu Gly Thr Lys His Gly Asp Ile Leu Pro 
                245                 250                 255     


Asn Ala Asp Gly Thr Trp Tyr Leu Gln Val Ile Leu Glu Val Ala Ser 
            260                 265                 270         


Glu Glu Pro Ala Gly Leu Ser Cys Arg Val Arg His Ser Ser Leu Gly 
        275                 280                 285             


Gly Gln Asp Ile Ile Leu Tyr Trp Gly His His Phe Ser Met Asn Trp 
    290                 295                 300                 


Ile Ala Leu Val Val Ile Val Pro Leu Val Ile Leu Ile Val Leu Val 
305                 310                 315                 320 


Leu Trp Phe Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
                325                 330             


<210>  1802
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD1D__Homo_sapiens__NP_001757

<400>  1802

Met Gly Cys Leu Leu Phe Leu Leu Leu Trp Ala Leu Leu Gln Ala Trp 
1               5                   10                  15      


Gly Ser Ala Glu Val Pro Gln Arg Leu Phe Pro Leu Arg Cys Leu Gln 
            20                  25                  30          


Ile Ser Ser Phe Ala Asn Ser Ser Trp Thr Arg Thr Asp Gly Leu Ala 
        35                  40                  45              


Trp Leu Gly Glu Leu Gln Thr His Ser Trp Ser Asn Asp Ser Asp Thr 
    50                  55                  60                  


Val Arg Ser Leu Lys Pro Trp Ser Gln Gly Thr Phe Ser Asp Gln Gln 
65                  70                  75                  80  


Trp Glu Thr Leu Gln His Ile Phe Arg Val Tyr Arg Ser Ser Phe Thr 
                85                  90                  95      


Arg Asp Val Lys Glu Phe Ala Lys Met Leu Arg Leu Ser Tyr Pro Leu 
            100                 105                 110         


Glu Leu Gln Val Ser Ala Gly Cys Glu Val His Pro Gly Asn Ala Ser 
        115                 120                 125             


Asn Asn Phe Phe His Val Ala Phe Gln Gly Lys Asp Ile Leu Ser Phe 
    130                 135                 140                 


Gln Gly Thr Ser Trp Glu Pro Thr Gln Glu Ala Pro Leu Trp Val Asn 
145                 150                 155                 160 


Leu Ala Ile Gln Val Leu Asn Gln Asp Lys Trp Thr Arg Glu Thr Val 
                165                 170                 175     


Gln Trp Leu Leu Asn Gly Thr Cys Pro Gln Phe Val Ser Gly Leu Leu 
            180                 185                 190         


Glu Ser Gly Lys Ser Glu Leu Lys Lys Gln Val Lys Pro Lys Ala Trp 
        195                 200                 205             


Leu Ser Arg Gly Pro Ser Pro Gly Pro Gly Arg Leu Leu Leu Val Cys 
    210                 215                 220                 


His Val Ser Gly Phe Tyr Pro Lys Pro Val Trp Val Lys Trp Met Arg 
225                 230                 235                 240 


Gly Glu Gln Glu Gln Gln Gly Thr Gln Pro Gly Asp Ile Leu Pro Asn 
                245                 250                 255     


Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr Leu Asp Val Val Ala Gly 
            260                 265                 270         


Glu Ala Ala Gly Leu Ser Cys Arg Val Lys His Ser Ser Leu Glu Gly 
        275                 280                 285             


Gln Asp Ile Val Leu Tyr Trp Gly Gly Ser Tyr Thr Ser Met Gly Leu 
    290                 295                 300                 


Ile Ala Leu Ala Val Leu Ala Cys Leu Leu Phe Leu Leu Ile Val Gly 
305                 310                 315                 320 


Phe Thr Ser Arg Phe Lys Arg Gln Thr Ser Tyr Gln Gly Val Leu 
                325                 330                 335 


<210>  1803
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD1E__Homo_sapiens__NP_001036048

<400>  1803

Met Leu Leu Leu Phe Leu Leu Phe Glu Gly Leu Cys Cys Pro Gly Glu 
1               5                   10                  15      


Asn Thr Ala Ala Pro Gln Ala Leu Gln Ser Tyr His Leu Ala Ala Glu 
            20                  25                  30          


Glu Gln Leu Ser Phe Arg Met Leu Gln Thr Ser Ser Phe Ala Asn His 
        35                  40                  45              


Ser Trp Ala His Ser Glu Gly Ser Gly Trp Leu Gly Asp Leu Gln Thr 
    50                  55                  60                  


His Gly Trp Asp Thr Val Leu Gly Thr Ile Arg Phe Leu Lys Pro Trp 
65                  70                  75                  80  


Ser His Gly Asn Phe Ser Lys Gln Glu Leu Lys Asn Leu Gln Ser Leu 
                85                  90                  95      


Phe Gln Leu Tyr Phe His Ser Phe Ile Gln Ile Val Gln Ala Ser Ala 
            100                 105                 110         


Gly Gln Phe Gln Leu Glu Tyr Pro Phe Glu Ile Gln Ile Leu Ala Gly 
        115                 120                 125             


Cys Arg Met Asn Ala Pro Gln Ile Phe Leu Asn Met Ala Tyr Gln Gly 
    130                 135                 140                 


Ser Asp Phe Leu Ser Phe Gln Gly Ile Ser Trp Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ile Arg Ala Gln Asn Ile Cys Lys Val Leu Asn Arg Tyr Leu 
                165                 170                 175     


Asp Ile Lys Glu Ile Leu Gln Ser Leu Leu Gly His Thr Cys Pro Arg 
            180                 185                 190         


Phe Leu Ala Gly Leu Met Glu Ala Gly Glu Ser Glu Leu Lys Arg Lys 
        195                 200                 205             


Val Lys Pro Glu Ala Trp Leu Ser Cys Gly Pro Ser Pro Gly Pro Gly 
    210                 215                 220                 


Arg Leu Gln Leu Val Cys His Val Ser Gly Phe Tyr Pro Lys Pro Val 
225                 230                 235                 240 


Trp Val Met Trp Met Arg Gly Glu Gln Glu Gln Arg Gly Thr Gln Arg 
                245                 250                 255     


Gly Asp Val Leu Pro Asn Ala Asp Glu Thr Trp Tyr Leu Arg Ala Thr 
            260                 265                 270         


Leu Asp Val Ala Ala Gly Glu Ala Ala Gly Leu Ser Cys Arg Val Lys 
        275                 280                 285             


His Ser Ser Leu Gly Gly His Asp Leu Ile Ile His Trp Gly Gly Tyr 
    290                 295                 300                 


Ser Ile Phe Leu Ile Leu Ile Cys Leu Thr Val Ile Val Thr Leu Val 
305                 310                 315                 320 


Ile Leu Val Val Val Asp Ser Arg Leu Lys Lys Gln Ser Pro Val Phe 
                325                 330                 335     


Leu Met Gly Ala Asn Thr Gln Asp Thr Lys Asn Ser Arg His Gln Phe 
            340                 345                 350         


Cys Leu Ala Gln Val Ser Trp Ile Lys Asn Arg Val Leu Lys Lys Trp 
        355                 360                 365             


Lys Thr Arg Leu Asn Gln Leu Trp 
    370                 375     


<210>  1804
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD200__Homo_sapiens__NP_001004196

<400>  1804

Met Glu Arg Leu Thr Leu Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr 
1               5                   10                  15      


Ala Thr Leu Leu Gly Lys Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg 
            20                  25                  30          


Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala 
        35                  40                  45              


Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu 
    50                  55                  60                  


Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn 
65                  70                  75                  80  


Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser 
                85                  90                  95      


Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln 
            100                 105                 110         


Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn 
        115                 120                 125             


Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr 
    130                 135                 140                 


Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala 
145                 150                 155                 160 


Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe 
                165                 170                 175     


Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala 
            180                 185                 190         


Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr 
        195                 200                 205             


Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu 
    210                 215                 220                 


His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln 
225                 230                 235                 240 


Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys 
                245                 250                 255     


Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val 
            260                 265                 270         


Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg 
        275                 280                 285             


Asn Gln Asp Arg Glu Pro 
    290                 


<210>  1805
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD200R1__Homo_sapiens__NP_620161

<400>  1805

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Glu Ala Glu Gly Ala Ala Gln Pro Asn Asn 
            20                  25                  30          


Ser Leu Met Leu Gln Thr Ser Lys Glu Asn His Ala Leu Ala Ser Ser 
        35                  40                  45              


Ser Leu Cys Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val 
    50                  55                  60                  


Leu Ala Glu Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala 
65                  70                  75                  80  


Val Leu Cys Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr 
                85                  90                  95      


Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys 
            100                 105                 110         


Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile 
        115                 120                 125             


Thr Trp Val Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr 
    130                 135                 140                 


Val Ala Ile Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro 
145                 150                 155                 160 


Asp Gly Asn Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro 
                165                 170                 175     


Glu Val Thr Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala 
            180                 185                 190         


Val Ala Gly Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp 
        195                 200                 205             


Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys 
    210                 215                 220                 


Ser Thr Cys His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His 
225                 230                 235                 240 


Val Ser His Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro 
                245                 250                 255     


Val Pro Gly Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile 
            260                 265                 270         


Leu Thr Ile Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys 
        275                 280                 285             


Val Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro 
    290                 295                 300                 


Val Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys 
305                 310                 315                 320 


Asn Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala 
                325                 330                 335     


Leu Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
            340                 345             


<210>  1806
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD207__Homo_sapiens__NP_056532

<400>  1806

Met Thr Val Glu Lys Glu Ala Pro Asp Ala His Phe Thr Val Asp Lys 
1               5                   10                  15      


Gln Asn Ile Ser Leu Trp Pro Arg Glu Pro Pro Pro Lys Ser Gly Pro 
            20                  25                  30          


Ser Leu Val Pro Gly Lys Thr Pro Thr Val Arg Ala Ala Leu Ile Cys 
        35                  40                  45              


Leu Thr Leu Val Leu Val Ala Ser Val Leu Leu Gln Ala Val Leu Tyr 
    50                  55                  60                  


Pro Arg Phe Met Gly Thr Ile Ser Asp Val Lys Thr Asn Val Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Arg Val Asp Asn Ile Ser Thr Leu Asp Ser Glu Ile Lys 
                85                  90                  95      


Lys Asn Ser Asp Gly Met Glu Ala Ala Gly Val Gln Ile Gln Met Val 
            100                 105                 110         


Asn Glu Ser Leu Gly Tyr Val Arg Ser Gln Phe Leu Lys Leu Lys Thr 
        115                 120                 125             


Ser Val Glu Lys Ala Asn Ala Gln Ile Gln Ile Leu Thr Arg Ser Trp 
    130                 135                 140                 


Glu Glu Val Ser Thr Leu Asn Ala Gln Ile Pro Glu Leu Lys Ser Asp 
145                 150                 155                 160 


Leu Glu Lys Ala Ser Ala Leu Asn Thr Lys Ile Arg Ala Leu Gln Gly 
                165                 170                 175     


Ser Leu Glu Asn Met Ser Lys Leu Leu Lys Arg Gln Asn Asp Ile Leu 
            180                 185                 190         


Gln Val Val Ser Gln Gly Trp Lys Tyr Phe Lys Gly Asn Phe Tyr Tyr 
        195                 200                 205             


Phe Ser Leu Ile Pro Lys Thr Trp Tyr Ser Ala Glu Gln Phe Cys Val 
    210                 215                 220                 


Ser Arg Asn Ser His Leu Thr Ser Val Thr Ser Glu Ser Glu Gln Glu 
225                 230                 235                 240 


Phe Leu Tyr Lys Thr Ala Gly Gly Leu Ile Tyr Trp Ile Gly Leu Thr 
                245                 250                 255     


Lys Ala Gly Met Glu Gly Asp Trp Ser Trp Val Asp Asp Thr Pro Phe 
            260                 265                 270         


Asn Lys Val Gln Ser Val Arg Phe Trp Ile Pro Gly Glu Pro Asn Asn 
        275                 280                 285             


Ala Gly Asn Asn Glu His Cys Gly Asn Ile Lys Ala Pro Ser Leu Gln 
    290                 295                 300                 


Ala Trp Asn Asp Ala Pro Cys Asp Lys Thr Phe Leu Phe Ile Cys Lys 
305                 310                 315                 320 


Arg Pro Tyr Val Pro Ser Glu Pro 
                325             


<210>  1807
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD209__Homo_sapiens__NP_001138365

<400>  1807

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Val 
1               5                   10                  15      


Ser Lys Val Pro Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala 
            20                  25                  30          


Ile Tyr Gln Asn Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser 
        35                  40                  45              


Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys 
    50                  55                  60                  


Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr 
65                  70                  75                  80  


Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys 
                85                  90                  95      


Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Trp Leu Lys Ala Ala 
            100                 105                 110         


Val Glu Arg Leu Cys His Pro Cys Pro Trp Glu Trp Thr Phe Phe Gln 
        115                 120                 125             


Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp Ser 
    130                 135                 140                 


Ile Thr Ala Cys Lys Glu Val Gly Ala Gln Leu Val Val Ile Lys Ser 
145                 150                 155                 160 


Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Ser Ser Arg Ser Asn Arg 
                165                 170                 175     


Phe Thr Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp Gln 
            180                 185                 190         


Trp Val Asp Gly Ser Pro Leu Leu Pro Ser Phe Lys Gln Tyr Trp Asn 
        195                 200                 205             


Arg Gly Glu Pro Asn Asn Val Gly Glu Glu Asp Cys Ala Glu Phe Ser 
    210                 215                 220                 


Gly Asn Gly Trp Asn Asp Asp Lys Cys Asn Leu Ala Lys Phe Trp Ile 
225                 230                 235                 240 


Cys Lys Lys Ser Ala Ala Ser Cys Ser Arg Asp Glu Glu Gln Phe Leu 
                245                 250                 255     


Ser Pro Ala Pro Ala Thr Pro Asn Pro Pro Pro Ala 
            260                 265             


<210>  1808
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD226__Homo_sapiens__NP_001290547

<400>  1808

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  1809
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD22__Homo_sapiens__NP_001172028

<400>  1809

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Pro Pro Lys Lys Val Thr Thr 
                325                 330                 335     


Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu 
            340                 345                 350         


Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp 
        355                 360                 365             


Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile 
    370                 375                 380                 


Gln Asn Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn 
385                 390                 395                 400 


Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala 
                405                 410                 415     


Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
            420                 425                 430         


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
        435                 440                 445             


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
    450                 455                 460                 


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
465                 470                 475                 480 


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
                485                 490                 495     


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
            500                 505                 510         


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 
        515                 520                 525             


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
    530                 535                 540                 


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
545                 550                 555                 560 


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
                565                 570                 575     


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
            580                 585                 590         


Pro Glu Thr Ile Gly Arg Arg Val Ala Val Gly Leu Gly Ser Cys Leu 
        595                 600                 605             


Ala Ile Leu Ile Leu Ala Ile Cys Gly Leu Lys Leu Gln Arg Arg Trp 
    610                 615                 620                 


Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln Glu Asn Ser Ser Gly Gln 
625                 630                 635                 640 


Ser Phe Phe Val Arg Asn Lys Lys Val Arg Arg Ala Pro Leu Ser Glu 
                645                 650                 655     


Gly Pro His Ser Leu Gly Cys Tyr Asn Pro Met Met Glu Asp Gly Ile 
            660                 665                 670         


Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met Asn Ile Pro Arg Thr Gly 
        675                 680                 685             


Asp Ala Glu Ser Ser Glu Met Gln Arg Pro Pro Pro Asp Cys Asp Asp 
    690                 695                 700                 


Thr Val Thr Tyr Ser Ala Leu His Lys Arg Gln Val Gly Asp Tyr Glu 
705                 710                 715                 720 


Asn Val Ile Pro Asp Phe Pro Glu Asp Glu Gly Ile His Tyr Ser Glu 
                725                 730                 735     


Leu Ile Gln Phe Gly Val Gly Glu Arg Pro Gln Ala Gln Glu Asn Val 
            740                 745                 750         


Asp Tyr Val Ile Leu Lys His 
        755                 


<210>  1810
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD244__Homo_sapiens__NP_001160135

<400>  1810

Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Glu Ser 
        115                 120                 125             


Leu Leu Pro Asp Lys Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys 
    130                 135                 140                 


Ile Leu Asp Arg Gly Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser 
145                 150                 155                 160 


Arg Asp Gly Asn Val Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile 
                165                 170                 175     


Gln Thr Ala Gly Asn Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn 
            180                 185                 190         


Gly Thr His Thr Tyr Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu 
        195                 200                 205             


Ser His Thr Leu Asn Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu 
    210                 215                 220                 


Phe Arg Phe Trp Pro Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys 
                245                 250                 255     


Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu 
            260                 265                 270         


Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr 
        275                 280                 285             


Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser 
    290                 295                 300                 


Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile 
305                 310                 315                 320 


Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser 
                325                 330                 335     


Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala 
            340                 345                 350         


Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val 
        355                 360                 365             


Tyr Ser 
    370 


<210>  1811
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD247__Homo_sapiens__NP_000725

<400>  1811

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  1812
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD248__Homo_sapiens__NP_065137

<400>  1812

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  1813
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD24__Homo_sapiens__XP_011533677

<400>  1813

Met Arg Thr Arg Asp Ala Pro Val Ser Ser Leu Arg Leu Ala Asp Thr 
1               5                   10                  15      


Arg Arg Ser Gln Asn Lys Ala Arg Ala Ser Gly Arg Ala Arg Pro Arg 
            20                  25                  30          


Gly Arg Ala Arg Arg Ser Leu Arg Thr Arg Thr Pro Pro Ala Arg Ser 
        35                  40                  45              


Ala Asp Gln Pro Gly Arg Val Arg Ala Arg Arg Arg Pro Gly Pro Val 
    50                  55                  60                  


Gly Gln Gly Leu Ala Gly Ser Pro Arg Ser Pro Pro Cys Leu Arg Pro 
65                  70                  75                  80  


Pro Gly Ala Ser Gly Ser Pro Ser Thr Gln His Pro Ala Arg Arg Ala 
                85                  90                  95      


Ala His Arg Arg Arg Gly His Gly Gln Ser Asn Gly Gly Gln Ala Arg 
            100                 105                 110         


Ala Gly Ala Ala Ala Ala Gly Thr Ala Pro Thr His Ala Val Arg Cys 
        115                 120                 125             


Ala Pro Glu Pro Ser Ser Ile Leu 
    130                 135     


<210>  1814
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD274__Homo_sapiens__NP_001254635

<400>  1814

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
            20                  25                  30          


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
        35                  40                  45              


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
    50                  55                  60                  


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
65                  70                  75                  80  


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
                85                  90                  95      


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
            100                 105                 110         


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
        115                 120                 125             


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
    130                 135                 140                 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
145                 150                 155                 160 


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
                165                 170                 175     


<210>  1815
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD276__Homo_sapiens__NP_079516

<400>  1815

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His 
    290                 295                 300                 


Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  1816
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27__Homo_sapiens__NP_001233

<400>  1816

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  1817
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28__Homo_sapiens__NP_001230007

<400>  1817

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  1818
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2AP__Homo_sapiens__NP_036252

<400>  1818

Met Val Asp Tyr Ile Val Glu Tyr Asp Tyr Asp Ala Val His Asp Asp 
1               5                   10                  15      


Glu Leu Thr Ile Arg Val Gly Glu Ile Ile Arg Asn Val Lys Lys Leu 
            20                  25                  30          


Gln Glu Glu Gly Trp Leu Glu Gly Glu Leu Asn Gly Arg Arg Gly Met 
        35                  40                  45              


Phe Pro Asp Asn Phe Val Lys Glu Ile Lys Arg Glu Thr Glu Phe Lys 
    50                  55                  60                  


Asp Asp Ser Leu Pro Ile Lys Arg Glu Arg His Gly Asn Val Ala Ser 
65                  70                  75                  80  


Leu Val Gln Arg Ile Ser Thr Tyr Gly Leu Pro Ala Gly Gly Ile Gln 
                85                  90                  95      


Pro His Pro Gln Thr Lys Asn Ile Lys Lys Lys Thr Lys Lys Arg Gln 
            100                 105                 110         


Cys Lys Val Leu Phe Glu Tyr Ile Pro Gln Asn Glu Asp Glu Leu Glu 
        115                 120                 125             


Leu Lys Val Gly Asp Ile Ile Asp Ile Asn Glu Glu Val Glu Glu Gly 
    130                 135                 140                 


Trp Trp Ser Gly Thr Leu Asn Asn Lys Leu Gly Leu Phe Pro Ser Asn 
145                 150                 155                 160 


Phe Val Lys Glu Leu Glu Val Thr Asp Asp Gly Glu Thr His Glu Ala 
                165                 170                 175     


Gln Asp Asp Ser Glu Thr Val Leu Ala Gly Pro Thr Ser Pro Ile Pro 
            180                 185                 190         


Ser Leu Gly Asn Val Ser Glu Thr Ala Ser Gly Ser Val Thr Gln Pro 
        195                 200                 205             


Lys Lys Ile Arg Gly Ile Gly Phe Gly Asp Ile Phe Lys Glu Gly Ser 
    210                 215                 220                 


Val Lys Leu Arg Thr Arg Thr Ser Ser Ser Glu Thr Glu Glu Lys Lys 
225                 230                 235                 240 


Pro Glu Lys Pro Leu Ile Leu Gln Ser Leu Gly Pro Lys Thr Gln Ser 
                245                 250                 255     


Val Glu Ile Thr Lys Thr Asp Thr Glu Gly Lys Ile Lys Ala Lys Glu 
            260                 265                 270         


Tyr Cys Arg Thr Leu Phe Ala Tyr Glu Gly Thr Asn Glu Asp Glu Leu 
        275                 280                 285             


Thr Phe Lys Glu Gly Glu Ile Ile His Leu Ile Ser Lys Glu Thr Gly 
    290                 295                 300                 


Glu Ala Gly Trp Trp Arg Gly Glu Leu Asn Gly Lys Glu Gly Val Phe 
305                 310                 315                 320 


Pro Asp Asn Phe Ala Val Gln Ile Asn Glu Leu Asp Lys Asp Phe Pro 
                325                 330                 335     


Lys Pro Lys Lys Pro Pro Pro Pro Ala Lys Ala Pro Ala Pro Lys Pro 
            340                 345                 350         


Glu Leu Ile Ala Ala Glu Lys Lys Tyr Phe Ser Leu Lys Pro Glu Glu 
        355                 360                 365             


Lys Asp Glu Lys Ser Thr Leu Glu Gln Lys Pro Ser Lys Pro Ala Ala 
    370                 375                 380                 


Pro Gln Val Pro Pro Lys Lys Pro Thr Pro Pro Thr Lys Ala Ser Asn 
385                 390                 395                 400 


Leu Leu Arg Ser Ser Gly Thr Val Tyr Pro Lys Arg Pro Glu Lys Pro 
                405                 410                 415     


Val Pro Pro Pro Pro Pro Ile Ala Lys Ile Asn Gly Glu Val Ser Ser 
            420                 425                 430         


Ile Ser Ser Lys Phe Glu Thr Glu Pro Val Ser Lys Leu Lys Leu Asp 
        435                 440                 445             


Ser Glu Gln Leu Pro Leu Arg Pro Lys Ser Val Asp Phe Asp Ser Leu 
    450                 455                 460                 


Thr Val Arg Thr Ser Lys Glu Thr Asp Val Val Asn Phe Asp Asp Ile 
465                 470                 475                 480 


Ala Ser Ser Glu Asn Leu Leu His Leu Thr Ala Asn Arg Pro Lys Met 
                485                 490                 495     


Pro Gly Arg Arg Leu Pro Gly Arg Phe Asn Gly Gly His Ser Pro Thr 
            500                 505                 510         


His Ser Pro Glu Lys Ile Leu Lys Leu Pro Lys Glu Glu Asp Ser Ala 
        515                 520                 525             


Asn Leu Lys Pro Ser Glu Leu Lys Lys Asp Thr Cys Tyr Ser Pro Lys 
    530                 535                 540                 


Pro Ser Val Tyr Leu Ser Thr Pro Ser Ser Ala Ser Lys Ala Asn Thr 
545                 550                 555                 560 


Thr Ala Phe Leu Thr Pro Leu Glu Ile Lys Ala Lys Val Glu Thr Asp 
                565                 570                 575     


Asp Val Lys Lys Asn Ser Leu Asp Glu Leu Arg Ala Gln Ile Ile Glu 
            580                 585                 590         


Leu Leu Cys Ile Val Glu Ala Leu Lys Lys Asp His Gly Lys Glu Leu 
        595                 600                 605             


Glu Lys Leu Arg Lys Asp Leu Glu Glu Glu Lys Thr Met Arg Ser Asn 
    610                 615                 620                 


Leu Glu Met Glu Ile Glu Lys Leu Lys Lys Ala Val Leu Ser Ser 
625                 630                 635                 


<210>  1819
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD300A__Homo_sapiens__NP_001243770

<400>  1819

Met Trp Leu Pro Trp Ala Leu Leu Leu Leu Trp Val Pro Ala Ser Thr 
1               5                   10                  15      


Ser Met Thr Pro Ala Ser Ile Thr Ala Ala Lys Thr Ser Thr Ile Thr 
            20                  25                  30          


Thr Ala Phe Pro Pro Val Ser Ser Thr Thr Leu Phe Ala Val Gly Ala 
        35                  40                  45              


Thr His Ser Ala Ser Ile Gln Glu Glu Thr Glu Glu Val Val Asn Ser 
    50                  55                  60                  


Gln Leu Pro Leu Leu Leu Ser Leu Leu Ala Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Val Gly Ala Ser Leu Leu Ala Trp Arg Met Phe Gln Lys Trp Ile Lys 
                85                  90                  95      


Ala Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Thr 
            100                 105                 110         


Gln Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu 
        115                 120                 125             


Gln Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Thr 
    130                 135                 140                 


Val Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp 
145                 150                 155                 160 


Ser Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro 
                165                 170                 175     


Asp Ser Asp Tyr Ser Val Ile Arg Lys Thr 
            180                 185     


<210>  1820
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD300C__Homo_sapiens__NP_006669

<400>  1820

Met Thr Ala Arg Ala Trp Ala Ser Trp Arg Ser Ser Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Val Pro Gly Tyr Phe Pro Leu Ser His Pro Met Thr Val Ala 
            20                  25                  30          


Gly Pro Val Gly Gly Ser Leu Ser Val Gln Cys Arg Tyr Glu Lys Glu 
        35                  40                  45              


His Arg Thr Leu Asn Lys Phe Trp Cys Arg Pro Pro Gln Ile Leu Arg 
    50                  55                  60                  


Cys Asp Lys Ile Val Glu Thr Lys Gly Ser Ala Gly Lys Arg Asn Gly 
65                  70                  75                  80  


Arg Val Ser Ile Arg Asp Ser Pro Ala Asn Leu Ser Phe Thr Val Thr 
                85                  90                  95      


Leu Glu Asn Leu Thr Glu Glu Asp Ala Gly Thr Tyr Trp Cys Gly Val 
            100                 105                 110         


Asp Thr Pro Trp Leu Arg Asp Phe His Asp Pro Ile Val Glu Val Glu 
        115                 120                 125             


Val Ser Val Phe Pro Ala Gly Thr Thr Thr Ala Ser Ser Pro Gln Ser 
    130                 135                 140                 


Ser Met Gly Thr Ser Gly Pro Pro Thr Lys Leu Pro Val His Thr Trp 
145                 150                 155                 160 


Pro Ser Val Thr Arg Lys Asp Ser Pro Glu Pro Ser Pro His Pro Gly 
                165                 170                 175     


Ser Leu Phe Ser Asn Val Arg Phe Leu Leu Leu Val Leu Leu Glu Leu 
            180                 185                 190         


Pro Leu Leu Leu Ser Met Leu Gly Ala Val Leu Trp Val Asn Arg Pro 
        195                 200                 205             


Gln Arg Ser Ser Arg Ser Arg Gln Asn Trp Pro Lys Gly Glu Asn Gln 
    210                 215                 220                 


<210>  1821
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD300LF__Homo_sapiens__NP_001276011

<400>  1821

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Ser Ser Arg Asp Val Pro Arg Ala Gly 
145                 150                 155                 160 


Thr Ala Ala Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp Pro Ala 
                165                 170                 175     


Ala Gly Arg Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe Leu Cys 
            180                 185                 190         


Pro Gly 
        


<210>  1822
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD302__Homo_sapiens__NP_001185692

<400>  1822

Met Leu Arg Ala Ala Leu Pro Ala Leu Leu Leu Pro Leu Leu Gly Leu 
1               5                   10                  15      


Ala Ala Ala Ala Val Ala Asp Cys Pro Ser Ser Thr Trp Ile Gln Phe 
            20                  25                  30          


Gln Asp Ser Cys Tyr Ile Phe Leu Gln Glu Ala Ile Lys Val Glu Ser 
        35                  40                  45              


Ile Glu Asp Val Arg Asn Gln Cys Thr Asp His Gly Ala Asp Met Ile 
    50                  55                  60                  


Ser Ile His Asn Glu Glu Glu Asn Ala Phe Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Lys Gln Trp Lys Gly Pro Asp Asp Ile Leu Leu Gly Met Phe Tyr Asp 
                85                  90                  95      


Thr Asp Val Pro Tyr Lys Arg Lys Tyr Leu Ser Asp Asn His Ile Leu 
            100                 105                 110         


Ile Ser Ala Leu Val Ile Ala Ser Thr Val Ile Leu Thr Val Leu Gly 
        115                 120                 125             


Ala Ile Ile Trp Phe Leu Tyr Lys Lys His Ser Asp Ser Arg Phe Thr 
    130                 135                 140                 


Thr Val Phe Ser Thr Ala Pro Gln Ser Pro Tyr Asn Glu Asp Cys Val 
145                 150                 155                 160 


Leu Val Val Gly Glu Glu Asn Glu Tyr Pro Val Gln Phe Asp 
                165                 170                 


<210>  1823
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD320__Homo_sapiens__NP_001159367

<400>  1823

Met Ser Gly Gly Trp Met Ala Gln Val Gly Ala Trp Arg Thr Gly Ala 
1               5                   10                  15      


Leu Gly Leu Ala Leu Leu Leu Leu Leu Gly Leu Gly Leu Gly Leu Glu 
            20                  25                  30          


Ala Ala Ala Ser Pro Leu Ser Thr Pro Thr Ser Ala Gln Ala Ala Gly 
        35                  40                  45              


Ile Glu Pro Cys Thr Gln Lys Gly Gln Cys Pro Pro Pro Pro Gly Leu 
    50                  55                  60                  


Pro Cys Pro Cys Thr Gly Val Ser Asp Cys Ser Gly Gly Thr Asp Lys 
65                  70                  75                  80  


Lys Leu Arg Asn Cys Ser Arg Leu Ala Cys Leu Ala Gly Glu Leu Arg 
                85                  90                  95      


Cys Thr Leu Ser Asp Asp Cys Ile Pro Leu Thr Trp Arg Cys Asp Gly 
            100                 105                 110         


His Pro Asp Cys Pro Asp Ser Ser Asp Glu Leu Gly Cys Gly Thr Asn 
        115                 120                 125             


Glu Ile Leu Pro Glu Gly Asp Ala Thr Thr Met Gly Pro Pro Val Thr 
    130                 135                 140                 


Leu Glu Ser Val Thr Ser Leu Arg Asn Ala Thr Thr Met Gly Pro Pro 
145                 150                 155                 160 


Val Thr Leu Glu Ser Val Pro Ser Val Gly Asn Ala Thr Ser Ser Ser 
                165                 170                 175     


Ala Gly Asp Gln Ser Gly Ser Pro Thr Ala Tyr Gly Val Ile Ala Ala 
            180                 185                 190         


Ala Ala Val Leu Ser Ala Ser Leu Val Thr Ala Thr Leu Leu Leu Leu 
        195                 200                 205             


Ser Trp Leu Arg Ala Gln Glu Arg Leu Arg Pro Leu Gly Leu Leu Val 
    210                 215                 220                 


Ala Met Lys Glu Ser Leu Leu Leu Ser Glu Gln Lys Thr Ser Leu Pro 
225                 230                 235                 240 


<210>  1824
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33__Homo_sapiens__NP_001076087

<400>  1824

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro 
            180                 185                 190         


Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         


<210>  1825
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD34__Homo_sapiens__NP_001020280

<400>  1825

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  1826
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD36__Homo_sapiens__NP_001001547

<400>  1826

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  1827
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD37__Homo_sapiens__NP_001765

<400>  1827

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210>  1828
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38__Homo_sapiens__NP_001766

<400>  1828

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  1829
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D__Homo_sapiens__NP_000723

<400>  1829

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  1830
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3EAP__Homo_sapiens__NP_036231

<400>  1830

Met Glu Glu Pro Gln Ala Gly Asp Ala Ala Arg Phe Ser Cys Pro Pro 
1               5                   10                  15      


Asn Phe Thr Ala Lys Pro Pro Ala Ser Glu Ser Pro Arg Phe Ser Leu 
            20                  25                  30          


Glu Ala Leu Thr Gly Pro Asp Thr Glu Leu Trp Leu Ile Gln Ala Pro 
        35                  40                  45              


Ala Asp Phe Ala Pro Glu Cys Phe Asn Gly Arg His Val Pro Leu Ser 
    50                  55                  60                  


Gly Ser Gln Ile Val Lys Gly Lys Leu Ala Gly Lys Arg His Arg Tyr 
65                  70                  75                  80  


Arg Val Leu Ser Ser Cys Pro Gln Ala Gly Glu Ala Thr Leu Leu Ala 
                85                  90                  95      


Pro Ser Thr Glu Ala Gly Gly Gly Leu Thr Cys Ala Ser Ala Pro Gln 
            100                 105                 110         


Gly Thr Leu Arg Ile Leu Glu Gly Pro Gln Gln Ser Leu Ser Gly Ser 
        115                 120                 125             


Pro Leu Gln Pro Ile Pro Ala Ser Pro Pro Pro Gln Ile Pro Pro Gly 
    130                 135                 140                 


Leu Arg Pro Arg Phe Cys Ala Phe Gly Gly Asn Pro Pro Val Thr Gly 
145                 150                 155                 160 


Pro Arg Ser Ala Leu Ala Pro Asn Leu Leu Thr Ser Gly Lys Lys Lys 
                165                 170                 175     


Lys Glu Met Gln Val Thr Glu Ala Pro Val Thr Gln Glu Ala Val Asn 
            180                 185                 190         


Gly His Gly Ala Leu Glu Val Asp Met Ala Leu Gly Ser Pro Glu Met 
        195                 200                 205             


Asp Val Arg Lys Lys Lys Lys Lys Lys Asn Gln Gln Leu Lys Glu Pro 
    210                 215                 220                 


Glu Ala Ala Gly Pro Val Gly Thr Glu Pro Thr Val Glu Thr Leu Glu 
225                 230                 235                 240 


Pro Leu Gly Val Leu Phe Pro Ser Thr Thr Lys Lys Arg Lys Lys Pro 
                245                 250                 255     


Lys Gly Lys Glu Thr Phe Glu Pro Glu Asp Lys Thr Val Lys Gln Glu 
            260                 265                 270         


Gln Ile Asn Thr Glu Pro Leu Glu Asp Thr Val Leu Ser Pro Thr Lys 
        275                 280                 285             


Lys Arg Lys Arg Gln Lys Gly Thr Glu Gly Met Glu Pro Glu Glu Gly 
    290                 295                 300                 


Val Thr Val Glu Ser Gln Pro Gln Val Lys Val Glu Pro Leu Glu Glu 
305                 310                 315                 320 


Ala Ile Pro Leu Pro Pro Thr Lys Lys Arg Lys Lys Glu Lys Gly Gln 
                325                 330                 335     


Met Ala Met Met Glu Pro Gly Thr Glu Ala Met Glu Pro Val Glu Pro 
            340                 345                 350         


Glu Met Lys Pro Leu Glu Ser Pro Gly Gly Thr Met Ala Pro Gln Gln 
        355                 360                 365             


Pro Glu Gly Ala Lys Pro Gln Ala Gln Ala Ala Leu Ala Ala Pro Lys 
    370                 375                 380                 


Lys Lys Thr Lys Lys Glu Lys Gln Gln Asp Ala Thr Val Glu Pro Glu 
385                 390                 395                 400 


Thr Glu Val Val Gly Pro Glu Leu Pro Asp Asp Leu Glu Pro Gln Ala 
                405                 410                 415     


Ala Pro Thr Ser Thr Lys Lys Lys Lys Lys Lys Lys Glu Arg Gly His 
            420                 425                 430         


Thr Val Thr Glu Pro Ile Gln Pro Leu Glu Pro Glu Leu Pro Gly Glu 
        435                 440                 445             


Gly Gln Pro Glu Ala Arg Ala Thr Pro Gly Ser Thr Lys Lys Arg Lys 
    450                 455                 460                 


Lys Gln Ser Gln Glu Ser Arg Met Pro Glu Thr Val Pro Gln Glu Glu 
465                 470                 475                 480 


Met Pro Gly Pro Pro Leu Asn Ser Glu Ser Gly Glu Glu Ala Pro Thr 
                485                 490                 495     


Gly Arg Asp Lys Lys Arg Lys Gln Gln Gln Gln Gln Pro Val 
            500                 505                 510 


<210>  1831
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E__Homo_sapiens__NP_000724

<400>  1831

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  1832
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G__Homo_sapiens__NP_000064

<400>  1832

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  1833
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40__Homo_sapiens__NP_001241

<400>  1833

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  1834
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40LG__Homo_sapiens__NP_000065

<400>  1834

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  1835
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD44__Homo_sapiens__NP_000601

<400>  1835

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  1836
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD46__Homo_sapiens__NP_002380

<400>  1836

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  1837
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47__Homo_sapiens__NP_001768

<400>  1837

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  1838
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD48__Homo_sapiens__NP_001769

<400>  1838

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210>  1839
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4__Homo_sapiens__NP_000607

<400>  1839

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  1840
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD55__Homo_sapiens__NP_000565

<400>  1840

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  1841
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD59__Homo_sapiens__NP_001120695

<400>  1841

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  1842
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5__Homo_sapiens__NP_055022

<400>  1842

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg 
    130                 135                 140                 


Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys 
            180                 185                 190         


Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro 
    210                 215                 220                 


Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln 
225                 230                 235                 240 


Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro 
                245                 250                 255     


Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr 
        275                 280                 285             


Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr 
                325                 330                 335     


Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu 
            340                 345                 350         


Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln 
        355                 360                 365             


Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile 
    370                 375                 380                 


Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu 
385                 390                 395                 400 


Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln 
                405                 410                 415     


Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn 
            420                 425                 430         


His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His 
        435                 440                 445             


Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala 
    450                 455                 460                 


Tyr Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp 
465                 470                 475                 480 


Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                485                 490                 495 


<210>  1843
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD5L__Homo_sapiens__NP_005885

<400>  1843

Met Ala Leu Leu Phe Ser Leu Ile Leu Ala Ile Cys Thr Arg Pro Gly 
1               5                   10                  15      


Phe Leu Ala Ser Pro Ser Gly Val Arg Leu Val Gly Gly Leu His Arg 
            20                  25                  30          


Cys Glu Gly Arg Val Glu Val Glu Gln Lys Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asp Gly Trp Asp Ile Lys Asp Val Ala Val Leu Cys Arg Glu 
    50                  55                  60                  


Leu Gly Cys Gly Ala Ala Ser Gly Thr Pro Ser Gly Ile Leu Tyr Glu 
65                  70                  75                  80  


Pro Pro Ala Glu Lys Glu Gln Lys Val Leu Ile Gln Ser Val Ser Cys 
                85                  90                  95      


Thr Gly Thr Glu Asp Thr Leu Ala Gln Cys Glu Gln Glu Glu Val Tyr 
            100                 105                 110         


Asp Cys Ser His Asp Glu Asp Ala Gly Ala Ser Cys Glu Asn Pro Glu 
        115                 120                 125             


Ser Ser Phe Ser Pro Val Pro Glu Gly Val Arg Leu Ala Asp Gly Pro 
    130                 135                 140                 


Gly His Cys Lys Gly Arg Val Glu Val Lys His Gln Asn Gln Trp Tyr 
145                 150                 155                 160 


Thr Val Cys Gln Thr Gly Trp Ser Leu Arg Ala Ala Lys Val Val Cys 
                165                 170                 175     


Arg Gln Leu Gly Cys Gly Arg Ala Val Leu Thr Gln Lys Arg Cys Asn 
            180                 185                 190         


Lys His Ala Tyr Gly Arg Lys Pro Ile Trp Leu Ser Gln Met Ser Cys 
        195                 200                 205             


Ser Gly Arg Glu Ala Thr Leu Gln Asp Cys Pro Ser Gly Pro Trp Gly 
    210                 215                 220                 


Lys Asn Thr Cys Asn His Asp Glu Asp Thr Trp Val Glu Cys Glu Asp 
225                 230                 235                 240 


Pro Phe Asp Leu Arg Leu Val Gly Gly Asp Asn Leu Cys Ser Gly Arg 
                245                 250                 255     


Leu Glu Val Leu His Lys Gly Val Trp Gly Ser Val Cys Asp Asp Asn 
            260                 265                 270         


Trp Gly Glu Lys Glu Asp Gln Val Val Cys Lys Gln Leu Gly Cys Gly 
        275                 280                 285             


Lys Ser Leu Ser Pro Ser Phe Arg Asp Arg Lys Cys Tyr Gly Pro Gly 
    290                 295                 300                 


Val Gly Arg Ile Trp Leu Asp Asn Val Arg Cys Ser Gly Glu Glu Gln 
305                 310                 315                 320 


Ser Leu Glu Gln Cys Gln His Arg Phe Trp Gly Phe His Asp Cys Thr 
                325                 330                 335     


His Gln Glu Asp Val Ala Val Ile Cys Ser Gly 
            340                 345         


<210>  1844
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD63__Homo_sapiens__NP_001244321

<400>  1844

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Gly Ala Thr Pro Gly Ser Leu Leu Pro Val 
            20                  25                  30          


Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly 
        35                  40                  45              


Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu Met Ile Thr Phe Ala 
    50                  55                  60                  


Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val Ala Ala Ala Ile Ala 
65                  70                  75                  80  


Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe 
                85                  90                  95      


Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile 
            100                 105                 110         


Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr 
        115                 120                 125             


Thr Asp Trp Glu Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp 
    130                 135                 140                 


Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu 
145                 150                 155                 160 


Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu 
                165                 170                 175     


Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe 
            180                 185                 190         


Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile 
        195                 200                 205             


Arg Ser Gly Tyr Glu Val Met 
    210                 215 


<210>  1845
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD68__Homo_sapiens__NP_001035148

<400>  1845

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Glu Ser Thr Gly Thr Thr Ser His Arg Thr Thr Lys Ser His Lys Thr 
            20                  25                  30          


Thr Thr His Arg Thr Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr 
        35                  40                  45              


Thr Ala Thr His Asn Pro Thr Thr Thr Ser His Gly Asn Val Thr Val 
    50                  55                  60                  


His Pro Thr Ser Asn Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala 
65                  70                  75                  80  


Thr His Ser Pro Ala Thr Thr Ser His Gly Asn Ala Thr Val His Pro 
                85                  90                  95      


Thr Ser Asn Ser Thr Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His 
            100                 105                 110         


Pro Glu Pro Pro Pro Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu 
        115                 120                 125             


Thr Ile Gly Asp Tyr Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His 
    130                 135                 140                 


Leu Gln Ala Gln Ile Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly 
145                 150                 155                 160 


Gly Glu Ala Trp Gly Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val 
                165                 170                 175     


Gln Gly Ser Cys Glu Gly Ala His Pro His Leu Leu Leu Ser Phe Pro 
            180                 185                 190         


Tyr Gly His Leu Ser Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val 
        195                 200                 205             


Val Tyr Leu Ser Tyr Met Ala Val Glu Tyr Asn Val Ser Phe Pro His 
    210                 215                 220                 


Ala Ala Gln Trp Thr Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu 
225                 230                 235                 240 


Gln Ala Pro Leu Gly Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile 
                245                 250                 255     


Leu Ser Pro Ala Val His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala 
            260                 265                 270         


Ala Gln Leu Pro His Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro 
        275                 280                 285             


Ser Asp Arg Ser Ile Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu 
    290                 295                 300                 


Gly Leu Leu Ala Leu Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg 
305                 310                 315                 320 


Pro Ser Ala Tyr Gln Ala Leu 
                325         


<210>  1846
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD69__Homo_sapiens__NP_001772

<400>  1846

Met Ser Ser Glu Asn Cys Phe Val Ala Glu Asn Ser Ser Leu His Pro 
1               5                   10                  15      


Glu Ser Gly Gln Glu Asn Asp Ala Thr Ser Pro His Phe Ser Thr Arg 
            20                  25                  30          


His Glu Gly Ser Phe Gln Val Pro Val Leu Cys Ala Val Met Asn Val 
        35                  40                  45              


Val Phe Ile Thr Ile Leu Ile Ile Ala Leu Ile Ala Leu Ser Val Gly 
    50                  55                  60                  


Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Ser Asp Ser 
65                  70                  75                  80  


His Val Ser Ser Cys Ser Glu Asp Trp Val Gly Tyr Gln Arg Lys Cys 
                85                  90                  95      


Tyr Phe Ile Ser Thr Val Lys Arg Ser Trp Thr Ser Ala Gln Asn Ala 
            100                 105                 110         


Cys Ser Glu His Gly Ala Thr Leu Ala Val Ile Asp Ser Glu Lys Asp 
        115                 120                 125             


Met Asn Phe Leu Lys Arg Tyr Ala Gly Arg Glu Glu His Trp Val Gly 
    130                 135                 140                 


Leu Lys Lys Glu Pro Gly His Pro Trp Lys Trp Ser Asn Gly Lys Glu 
145                 150                 155                 160 


Phe Asn Asn Trp Phe Asn Val Thr Gly Ser Asp Lys Cys Val Phe Leu 
                165                 170                 175     


Lys Asn Thr Glu Val Ser Ser Met Glu Cys Glu Lys Asn Leu Tyr Trp 
            180                 185                 190         


Ile Cys Asn Lys Pro Tyr Lys 
        195                 


<210>  1847
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD6__Homo_sapiens__NP_001241679

<400>  1847

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe 
            420                 425                 430         


Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser 
        435                 440                 445             


Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro 
    450                 455                 460                 


Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp 
465                 470                 475                 480 


Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly 
                485                 490                 495     


Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His 
            500                 505                 510         


Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser 
        515                 520                 525             


Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro 
    530                 535                 540                 


Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg 
545                 550                 555                 560 


Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln 
                565                 570                 575     


Pro Ala Phe Ser Gly Ser Pro Ser Pro Gln Pro Asp Ser Thr Asp Asn 
            580                 585                 590         


Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
        595                 600     


<210>  1848
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD72__Homo_sapiens__NP_001773

<400>  1848

Met Ala Glu Ala Ile Thr Tyr Ala Asp Leu Arg Phe Val Lys Ala Pro 
1               5                   10                  15      


Leu Lys Lys Ser Ile Ser Ser Arg Leu Gly Gln Asp Pro Gly Ala Asp 
            20                  25                  30          


Asp Asp Gly Glu Ile Thr Tyr Glu Asn Val Gln Val Pro Ala Val Leu 
        35                  40                  45              


Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 
    50                  55                  60                  


Val Lys Ser Glu Gln Pro Thr Ala Ser Trp Arg Ala Val Thr Ser Pro 
65                  70                  75                  80  


Ala Val Gly Arg Ile Leu Pro Cys Arg Thr Thr Cys Leu Arg Tyr Leu 
                85                  90                  95      


Leu Leu Gly Leu Leu Leu Thr Cys Leu Leu Leu Gly Val Thr Ala Ile 
            100                 105                 110         


Cys Leu Gly Val Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr 
        115                 120                 125             


Asn Arg Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg 
    130                 135                 140                 


Leu Lys Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser 
145                 150                 155                 160 


Arg Arg Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg 
                165                 170                 175     


Ala His Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg 
            180                 185                 190         


Gln Lys Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala 
        195                 200                 205             


Leu Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe 
    210                 215                 220                 


Thr Cys Gly Ser Ala Asp Thr Cys Cys Pro Ser Gly Trp Ile Met His 
225                 230                 235                 240 


Gln Lys Ser Cys Phe Tyr Ile Ser Leu Thr Ser Lys Asn Trp Gln Glu 
                245                 250                 255     


Ser Gln Lys Gln Cys Glu Thr Leu Ser Ser Lys Leu Ala Thr Phe Ser 
            260                 265                 270         


Glu Ile Tyr Pro Gln Ser His Ser Tyr Tyr Phe Leu Asn Ser Leu Leu 
        275                 280                 285             


Pro Asn Gly Gly Ser Gly Asn Ser Tyr Trp Thr Gly Leu Ser Ser Asn 
    290                 295                 300                 


Lys Asp Trp Lys Leu Thr Asp Asp Thr Gln Arg Thr Arg Thr Tyr Ala 
305                 310                 315                 320 


Gln Ser Ser Lys Cys Asn Lys Val His Lys Thr Trp Ser Trp Trp Thr 
                325                 330                 335     


Leu Glu Ser Glu Ser Cys Arg Ser Ser Leu Pro Tyr Ile Cys Glu Met 
            340                 345                 350         


Thr Ala Phe Arg Phe Pro Asp 
        355                 


<210>  1849
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD74__Homo_sapiens__NP_001020329

<400>  1849

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Ser His Trp Asn Trp Arg Thr Arg Leu Leu Gly Trp Val 
145                 150                 155                 160 


<210>  1850
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD79A__Homo_sapiens__NP_001774

<400>  1850

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  1851
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD79B__Homo_sapiens__NP_000617

<400>  1851

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu 
        195                 200                 205             


Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210>  1852
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD7__Homo_sapiens__NP_006128

<400>  1852

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu 
        195                 200                 205             


Cys Ser Trp Arg Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp 
    210                 215                 220                 


Met Ser His Ser Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
225                 230                 235                 240 


<210>  1853
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80__Homo_sapiens__NP_005182

<400>  1853

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  1854
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81__Homo_sapiens__NP_004347

<400>  1854

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  1855
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD82__Homo_sapiens__NP_001020015

<400>  1855

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Leu Lys Gln Glu Met Gly Gly Ile Val 
                85                  90                  95      


Thr Glu Leu Ile Arg Asp Tyr Asn Ser Ser Arg Glu Asp Ser Leu Gln 
            100                 105                 110         


Asp Ala Trp Asp Tyr Val Gln Ala Gln Val Lys Cys Cys Gly Trp Val 
        115                 120                 125             


Ser Phe Tyr Asn Trp Thr Asp Asn Ala Glu Leu Met Asn Arg Pro Glu 
    130                 135                 140                 


Val Thr Tyr Pro Cys Ser Cys Glu Val Lys Gly Glu Glu Asp Asn Ser 
145                 150                 155                 160 


Leu Ser Val Arg Lys Gly Phe Cys Glu Ala Pro Gly Asn Arg Thr Gln 
                165                 170                 175     


Ser Gly Asn His Pro Glu Asp Trp Pro Val Tyr Gln Glu Gly Cys Met 
            180                 185                 190         


Glu Lys Val Gln Ala Trp Leu Gln Glu Asn Leu Gly Ile Ile Leu Gly 
        195                 200                 205             


Val Gly Val Gly Val Ala Ile Ile Glu Leu Leu Gly Met Val Leu Ser 
    210                 215                 220                 


Ile Cys Leu Cys Arg His Val His Ser Glu Asp Tyr Ser Lys Val Pro 
225                 230                 235                 240 


Lys Tyr 
        


<210>  1856
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD83__Homo_sapiens__NP_004224

<400>  1856

Met Ser Arg Gly Leu Gln Leu Leu Leu Leu Ser Cys Ala Tyr Ser Leu 
1               5                   10                  15      


Ala Pro Ala Thr Pro Glu Val Lys Val Ala Cys Ser Glu Asp Val Asp 
            20                  25                  30          


Leu Pro Cys Thr Ala Pro Trp Asp Pro Gln Val Pro Tyr Thr Val Ser 
        35                  40                  45              


Trp Val Lys Leu Leu Glu Gly Gly Glu Glu Arg Met Glu Thr Pro Gln 
    50                  55                  60                  


Glu Asp His Leu Arg Gly Gln His Tyr His Gln Lys Gly Gln Asn Gly 
65                  70                  75                  80  


Ser Phe Asp Ala Pro Asn Glu Arg Pro Tyr Ser Leu Lys Ile Arg Asn 
                85                  90                  95      


Thr Thr Ser Cys Asn Ser Gly Thr Tyr Arg Cys Thr Leu Gln Asp Pro 
            100                 105                 110         


Asp Gly Gln Arg Asn Leu Ser Gly Lys Val Ile Leu Arg Val Thr Gly 
        115                 120                 125             


Cys Pro Ala Gln Arg Lys Glu Glu Thr Phe Lys Lys Tyr Arg Ala Glu 
    130                 135                 140                 


Ile Val Leu Leu Leu Ala Leu Val Ile Phe Tyr Leu Thr Leu Ile Ile 
145                 150                 155                 160 


Phe Thr Cys Lys Phe Ala Arg Leu Gln Ser Ile Phe Pro Asp Phe Ser 
                165                 170                 175     


Lys Ala Gly Met Glu Arg Ala Phe Leu Pro Val Thr Ser Pro Asn Lys 
            180                 185                 190         


His Leu Gly Leu Val Thr Pro His Lys Thr Glu Leu Val 
        195                 200                 205 


<210>  1857
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD84__Homo_sapiens__NP_001171808

<400>  1857

Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 
1               5                   10                  15      


Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 
        35                  40                  45              


Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 
    50                  55                  60                  


Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 
65                  70                  75                  80  


Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 
                85                  90                  95      


Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 
            100                 105                 110         


Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 
        115                 120                 125             


Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 
    130                 135                 140                 


Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 
145                 150                 155                 160 


Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 
                165                 170                 175     


Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 
            180                 185                 190         


Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 
        195                 200                 205             


Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 
    210                 215                 220                 


Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
225                 230                 235                 240 


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile 
                245                 250                 255     


Phe Pro Glu Gly Ser Cys Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala 
            260                 265                 270         


Ala Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr 
        275                 280                 285             


Gln Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val 
    290                 295                 300                 


Leu Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln 
305                 310                 315                 320 


Phe Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro 
                325                 330                 335     


Gly Thr Ser Ser Tyr Glu Ile Val Ile 
            340                 345 


<210>  1858
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86__Homo_sapiens__NP_001193853

<400>  1858

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
            20                  25                  30          


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
        35                  40                  45              


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
    50                  55                  60                  


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
65                  70                  75                  80  


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
                85                  90                  95      


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
            100                 105                 110         


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
        115                 120                 125             


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
    130                 135                 140                 


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
145                 150                 155                 160 


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
                165                 170                 175     


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
            180                 185                 190         


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
        195                 200                 205             


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    210                 215         


<210>  1859
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8A__Homo_sapiens__NP_001759

<400>  1859

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  1860
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8B__Homo_sapiens__NP_001171571

<400>  1860

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Leu Lys Gly Lys Val Tyr Gln Glu Pro Leu Ser 
                165                 170                 175     


Pro Asn Ala Cys Met Asp Thr Thr Ala Ile Leu Gln Pro His Arg Ser 
            180                 185                 190         


Cys Leu Thr His Gly Ser 
        195             


<210>  1861
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD93__Homo_sapiens__NP_036204

<400>  1861

Met Ala Thr Ser Met Gly Leu Leu Leu Leu Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Gln Pro Gly Ala Gly Thr Gly Ala Asp Thr Glu Ala Val Val Cys Val 
            20                  25                  30          


Gly Thr Ala Cys Tyr Thr Ala His Ser Gly Lys Leu Ser Ala Ala Glu 
        35                  40                  45              


Ala Gln Asn His Cys Asn Gln Asn Gly Gly Asn Leu Ala Thr Val Lys 
    50                  55                  60                  


Ser Lys Glu Glu Ala Gln His Val Gln Arg Val Leu Ala Gln Leu Leu 
65                  70                  75                  80  


Arg Arg Glu Ala Ala Leu Thr Ala Arg Met Ser Lys Phe Trp Ile Gly 
                85                  90                  95      


Leu Gln Arg Glu Lys Gly Lys Cys Leu Asp Pro Ser Leu Pro Leu Lys 
            100                 105                 110         


Gly Phe Ser Trp Val Gly Gly Gly Glu Asp Thr Pro Tyr Ser Asn Trp 
        115                 120                 125             


His Lys Glu Leu Arg Asn Ser Cys Ile Ser Lys Arg Cys Val Ser Leu 
    130                 135                 140                 


Leu Leu Asp Leu Ser Gln Pro Leu Leu Pro Ser Arg Leu Pro Lys Trp 
145                 150                 155                 160 


Ser Glu Gly Pro Cys Gly Ser Pro Gly Ser Pro Gly Ser Asn Ile Glu 
                165                 170                 175     


Gly Phe Val Cys Lys Phe Ser Phe Lys Gly Met Cys Arg Pro Leu Ala 
            180                 185                 190         


Leu Gly Gly Pro Gly Gln Val Thr Tyr Thr Thr Pro Phe Gln Thr Thr 
        195                 200                 205             


Ser Ser Ser Leu Glu Ala Val Pro Phe Ala Ser Ala Ala Asn Val Ala 
    210                 215                 220                 


Cys Gly Glu Gly Asp Lys Asp Glu Thr Gln Ser His Tyr Phe Leu Cys 
225                 230                 235                 240 


Lys Glu Lys Ala Pro Asp Val Phe Asp Trp Gly Ser Ser Gly Pro Leu 
                245                 250                 255     


Cys Val Ser Pro Lys Tyr Gly Cys Asn Phe Asn Asn Gly Gly Cys His 
            260                 265                 270         


Gln Asp Cys Phe Glu Gly Gly Asp Gly Ser Phe Leu Cys Gly Cys Arg 
        275                 280                 285             


Pro Gly Phe Arg Leu Leu Asp Asp Leu Val Thr Cys Ala Ser Arg Asn 
    290                 295                 300                 


Pro Cys Ser Ser Ser Pro Cys Arg Gly Gly Ala Thr Cys Val Leu Gly 
305                 310                 315                 320 


Pro His Gly Lys Asn Tyr Thr Cys Arg Cys Pro Gln Gly Tyr Gln Leu 
                325                 330                 335     


Asp Ser Ser Gln Leu Asp Cys Val Asp Val Asp Glu Cys Gln Asp Ser 
            340                 345                 350         


Pro Cys Ala Gln Glu Cys Val Asn Thr Pro Gly Gly Phe Arg Cys Glu 
        355                 360                 365             


Cys Trp Val Gly Tyr Glu Pro Gly Gly Pro Gly Glu Gly Ala Cys Gln 
    370                 375                 380                 


Asp Val Asp Glu Cys Ala Leu Gly Arg Ser Pro Cys Ala Gln Gly Cys 
385                 390                 395                 400 


Thr Asn Thr Asp Gly Ser Phe His Cys Ser Cys Glu Glu Gly Tyr Val 
                405                 410                 415     


Leu Ala Gly Glu Asp Gly Thr Gln Cys Gln Asp Val Asp Glu Cys Val 
            420                 425                 430         


Gly Pro Gly Gly Pro Leu Cys Asp Ser Leu Cys Phe Asn Thr Gln Gly 
        435                 440                 445             


Ser Phe His Cys Gly Cys Leu Pro Gly Trp Val Leu Ala Pro Asn Gly 
    450                 455                 460                 


Val Ser Cys Thr Met Gly Pro Val Ser Leu Gly Pro Pro Ser Gly Pro 
465                 470                 475                 480 


Pro Asp Glu Glu Asp Lys Gly Glu Lys Glu Gly Ser Thr Val Pro Arg 
                485                 490                 495     


Ala Ala Thr Ala Ser Pro Thr Arg Gly Pro Glu Gly Thr Pro Lys Ala 
            500                 505                 510         


Thr Pro Thr Thr Ser Arg Pro Ser Leu Ser Ser Asp Ala Pro Ile Thr 
        515                 520                 525             


Ser Ala Pro Leu Lys Met Leu Ala Pro Ser Gly Ser Pro Gly Val Trp 
    530                 535                 540                 


Arg Glu Pro Ser Ile His His Ala Thr Ala Ala Ser Gly Pro Gln Glu 
545                 550                 555                 560 


Pro Ala Gly Gly Asp Ser Ser Val Ala Thr Gln Asn Asn Asp Gly Thr 
                565                 570                 575     


Asp Gly Gln Lys Leu Leu Leu Phe Tyr Ile Leu Gly Thr Val Val Ala 
            580                 585                 590         


Ile Leu Leu Leu Leu Ala Leu Ala Leu Gly Leu Leu Val Tyr Arg Lys 
        595                 600                 605             


Arg Arg Ala Lys Arg Glu Glu Lys Lys Glu Lys Lys Pro Gln Asn Ala 
    610                 615                 620                 


Ala Asp Ser Tyr Ser Trp Val Pro Glu Arg Ala Glu Ser Arg Ala Met 
625                 630                 635                 640 


Glu Asn Gln Tyr Ser Pro Thr Pro Gly Thr Asp Cys 
                645                 650         


<210>  1862
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD96__Homo_sapiens__NP_005807

<400>  1862

Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
            180                 185                 190         


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
        195                 200                 205             


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
    210                 215                 220                 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
225                 230                 235                 240 


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
                245                 250                 255     


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
            260                 265                 270         


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
        275                 280                 285             


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
    290                 295                 300                 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
305                 310                 315                 320 


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
                325                 330                 335     


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
            340                 345                 350         


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
        355                 360                 365             


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
    370                 375                 380                 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
385                 390                 395                 400 


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
                405                 410                 415     


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
            420                 425                 430         


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
        435                 440                 445             


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
    450                 455                 460                 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
465                 470                 475                 480 


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
                485                 490                 495     


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
            500                 505                 510         


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
        515                 520                 525             


Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro Pro 
    530                 535                 540                 


Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro Asn Glu Ser Asp 
545                 550                 555                 560 


Leu Pro Tyr His Glu Met Glu Thr Leu 
                565                 


<210>  1863
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD99__Homo_sapiens__NP_001116370

<400>  1863

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
        35                  40                  45              


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
    50                  55                  60                  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
                85                  90                  95      


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
            100                 105                 110         


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
        115                 120                 125             


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
    130                 135                 140                 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
145                 150                 155                 160 


Ala Val Gln Arg Thr Leu Leu Glu Lys 
                165                 


<210>  1864
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD9__Homo_sapiens__NP_001760

<400>  1864

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210>  1865
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDADC1__Homo_sapiens__NP_001180407

<400>  1865

Met Lys Glu Ala Gly Gln Met Gln Asn Leu Glu Ser Ala Arg Ala Gly 
1               5                   10                  15      


Arg Ser Val Ser Thr Gln Thr Gly Ser Met Thr Gly Gln Ile Pro Arg 
            20                  25                  30          


Leu Ser Lys Val Asn Leu Phe Thr Leu Leu Ser Leu Trp Met Glu Leu 
        35                  40                  45              


Phe Pro Ala Glu Ala Gln Arg Gln Lys Ser Gln Lys Asn Glu Glu Gly 
    50                  55                  60                  


Lys His Gly Pro Leu Gly Asp Asn Glu Glu Arg Thr Arg Val Ser Thr 
65                  70                  75                  80  


Asp Lys Arg Gln Val Lys Arg Thr Gly Leu Val Val Val Lys Asn Met 
                85                  90                  95      


Lys Ile Val Gly Leu His Cys Ser Ser Glu Asp Leu His Ala Gly Gln 
            100                 105                 110         


Ile Ala Leu Ile Lys His Gly Ser Arg Leu Lys Asn Cys Asp Leu Tyr 
        115                 120                 125             


Phe Ser Arg Lys Pro Cys Ser Ala Cys Leu Lys Met Ile Val Asn Ala 
    130                 135                 140                 


Gly Val Asn Arg Ile Ser Tyr Trp Pro Ala Asp Pro Glu Ile Ser Leu 
145                 150                 155                 160 


Leu Thr Glu Ala Ser Ser Ser Glu Asp Ala Lys Leu Asp Ala Lys Ala 
                165                 170                 175     


Val Glu Arg Leu Lys Ser Asn Ser Arg Ala His Val Cys Val Leu Leu 
            180                 185                 190         


Gln Pro Leu Val Cys Tyr Met Val Gln Phe Val Glu Glu Thr Ser Tyr 
        195                 200                 205             


Lys Cys Asp Phe Ile Gln Lys Ile Thr Lys Thr Leu Pro Asp Ala Asn 
    210                 215                 220                 


Thr Asp Phe Tyr Tyr Glu Cys Lys Gln Glu Arg Ile Lys Glu Tyr Glu 
225                 230                 235                 240 


Met Leu Phe Leu Val Ser Asn Glu Glu Met His Lys Gln Ile Leu Met 
                245                 250                 255     


Thr Ile Gly Leu Glu Asn Leu Cys Glu Asn Pro Tyr Phe Ser Asn Leu 
            260                 265                 270         


Arg Gln Asn Met Lys Asp Leu Ile Leu Leu Leu Ala Thr Val Ala Ser 
        275                 280                 285             


Ser Val Pro Asn Phe Lys His Phe Gly Phe Tyr Arg Ser Asn Pro Glu 
    290                 295                 300                 


Gln Ile Asn Glu Ile His Asn Gln Ser Leu Pro Gln Glu Ile Ala Arg 
305                 310                 315                 320 


His Cys Met Val Gln Ala Arg Leu Leu Ala Tyr Arg Thr Glu Asp His 
                325                 330                 335     


Lys Thr Gly Val Gly Ala Val Ile Trp Ala Glu Gly Lys Ser Arg Ser 
            340                 345                 350         


Cys Asp Gly Thr Gly Ala Met Tyr Phe Val Gly Cys Gly Tyr Asn Ala 
        355                 360                 365             


Phe Pro Val Gly Ser Glu Tyr Ala Asp Phe Pro His Met Asp Asp Lys 
    370                 375                 380                 


Gln Lys Asp Arg Glu Ile Arg Lys Phe Arg Tyr Ile Ile His Ala Glu 
385                 390                 395                 400 


Gln Asn Ala Leu Thr Phe Arg Cys Gln Glu Ile Lys Pro Glu Glu Arg 
                405                 410                 415     


Ser Met Ile Phe Val Thr Lys Cys Pro Cys Asp Glu Cys Val Pro Leu 
            420                 425                 430         


Ile Lys Gly Ala Gly Ile Lys Gln Ile Tyr Ala Gly Asp Val Asp Val 
        435                 440                 445             


Gly Lys Lys Lys Ala Asp Ile Ser Tyr Met Arg Phe Gly Glu Leu Glu 
    450                 455                 460                 


Gly Val Ser Lys Phe Thr Trp Gln Leu Asn Pro Ser Gly Ala Tyr Gly 
465                 470                 475                 480 


Leu Glu Gln Asn Glu Pro Glu Arg Arg Glu Ser 
                485                 490     


<210>  1866
<211>  1227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDAN1__Homo_sapiens__NP_612486

<400>  1866

Met Ala Ala Val Leu Glu Ser Leu Leu Arg Glu Glu Val Ser Val Ala 
1               5                   10                  15      


Ala Val Val Arg Trp Ile Ala Arg Ser Thr Gln Gly Ser Glu Asp Asn 
            20                  25                  30          


Ala Gly Glu Ala Ala Ala Leu Ser Ser Leu Arg Ala Leu Arg Lys Glu 
        35                  40                  45              


Phe Val Pro Phe Leu Leu Asn Phe Leu Arg Glu Gln Ser Ser Arg Val 
    50                  55                  60                  


Leu Pro Gln Gly Pro Pro Thr Pro Ala Lys Thr Pro Gly Ala Ser Ala 
65                  70                  75                  80  


Ala Leu Pro Gly Arg Pro Gly Gly Pro Pro Arg Gly Ser Arg Gly Ala 
                85                  90                  95      


Arg Ser Gln Leu Phe Pro Pro Thr Glu Ala Gln Ser Thr Ala Ala Glu 
            100                 105                 110         


Ala Pro Leu Ala Arg Arg Gly Gly Arg Arg Arg Gly Pro Gly Pro Ala 
        115                 120                 125             


Arg Glu Arg Gly Gly Arg Gly Leu Glu Glu Gly Val Ser Gly Glu Ser 
    130                 135                 140                 


Leu Pro Gly Ala Gly Gly Arg Arg Leu Arg Gly Ser Gly Ser Pro Ser 
145                 150                 155                 160 


Arg Pro Ser Leu Thr Leu Ser Asp Pro Pro Asn Leu Ser Asn Leu Glu 
                165                 170                 175     


Glu Phe Pro Pro Val Gly Ser Val Pro Pro Gly Pro Thr Gly Thr Lys 
            180                 185                 190         


Pro Ser Arg Arg Ile Asn Pro Thr Pro Val Ser Glu Glu Arg Ser Leu 
        195                 200                 205             


Ser Lys Pro Lys Thr Cys Phe Thr Ser Pro Pro Ile Ser Cys Val Pro 
    210                 215                 220                 


Ser Ser Gln Pro Ser Ala Leu Asp Thr Ser Pro Trp Gly Leu Gly Leu 
225                 230                 235                 240 


Pro Pro Gly Cys Arg Ser Leu Gln Glu Glu Arg Glu Met Leu Arg Lys 
                245                 250                 255     


Glu Arg Ser Lys Gln Leu Gln Gln Ser Pro Thr Pro Thr Cys Pro Thr 
            260                 265                 270         


Pro Glu Leu Gly Ser Pro Leu Pro Ser Arg Thr Gly Ser Leu Thr Asp 
        275                 280                 285             


Glu Pro Ala Asp Pro Ala Arg Val Ser Ser Arg Gln Arg Leu Glu Leu 
    290                 295                 300                 


Val Ala Leu Val Tyr Ser Ser Cys Ile Ala Glu Asn Leu Val Pro Asn 
305                 310                 315                 320 


Leu Phe Leu Glu Leu Phe Phe Val Phe Gln Leu Leu Thr Ala Arg Arg 
                325                 330                 335     


Met Val Thr Ala Lys Asp Ser Asp Pro Glu Leu Ser Pro Ala Val Leu 
            340                 345                 350         


Asp Ser Leu Glu Ser Pro Leu Phe Gln Ser Ile His Asp Cys Val Phe 
        355                 360                 365             


Phe Ala Val Gln Val Leu Glu Cys His Phe Gln Val Leu Ser Asn Leu 
    370                 375                 380                 


Asp Lys Gly Thr Leu Lys Leu Leu Ala Glu Asn Glu Arg Leu Leu Cys 
385                 390                 395                 400 


Phe Ser Pro Ala Leu Gln Gly Arg Leu Arg Ala Ala Tyr Glu Gly Ser 
                405                 410                 415     


Val Ala Lys Val Ser Leu Val Met Pro Pro Ser Thr Gln Ala Val Ser 
            420                 425                 430         


Phe Gln Pro Glu Thr Asp Asn Arg Ala Asn Phe Ser Ser Asp Arg Ala 
        435                 440                 445             


Phe His Thr Phe Lys Lys Gln Arg Asp Val Phe Tyr Glu Val Leu Arg 
    450                 455                 460                 


Glu Trp Glu Asp His His Glu Glu Pro Gly Trp Asp Phe Glu Lys Gly 
465                 470                 475                 480 


Leu Gly Ser Arg Ile Arg Ala Met Met Gly Gln Leu Ser Ala Ala Cys 
                485                 490                 495     


Ser His Ser His Phe Val Arg Leu Phe Gln Lys Gln Leu Leu Gln Met 
            500                 505                 510         


Cys Gln Ser Pro Gly Gly Ala Gly Gly Thr Val Leu Gly Glu Ala Pro 
        515                 520                 525             


Asp Val Leu Ser Met Leu Gly Ala Asp Lys Leu Gly Arg Leu Trp Arg 
    530                 535                 540                 


Leu Gln Glu Arg Leu Met Ala Pro Gln Ser Ser Gly Gly Pro Cys Pro 
545                 550                 555                 560 


Pro Pro Thr Phe Pro Gly Cys Gln Gly Phe Phe Arg Asp Phe Ile Leu 
                565                 570                 575     


Ser Ala Ser Ser Phe Gln Phe Asn Gln His Leu Met Asp Ser Leu Ser 
            580                 585                 590         


Leu Lys Ile Gln Glu Leu Asn Gly Leu Ala Leu Pro Gln His Glu Pro 
        595                 600                 605             


Asn Asp Glu Asp Gly Glu Ser Asp Val Asp Trp Gln Gly Glu Arg Lys 
    610                 615                 620                 


Gln Phe Ala Val Val Leu Leu Ser Leu Arg Leu Leu Ala Lys Phe Leu 
625                 630                 635                 640 


Gly Phe Val Ala Phe Leu Pro Tyr Arg Gly Pro Glu Pro Pro Pro Thr 
                645                 650                 655     


Gly Glu Leu Gln Asp Ser Ile Leu Ala Leu Arg Ser Gln Val Pro Pro 
            660                 665                 670         


Val Leu Asp Val Arg Thr Leu Leu Gln Arg Gly Leu Gln Ala Arg Arg 
        675                 680                 685             


Ala Val Leu Thr Val Pro Trp Leu Val Glu Phe Leu Ser Phe Ala Asp 
    690                 695                 700                 


His Val Val Pro Leu Leu Glu Tyr Tyr Arg Asp Ile Phe Thr Leu Leu 
705                 710                 715                 720 


Leu Arg Leu His Arg Ser Leu Val Leu Ser Gln Glu Ser Glu Gly Lys 
                725                 730                 735     


Met Cys Phe Leu Asn Lys Leu Leu Leu Leu Ala Val Leu Gly Trp Leu 
            740                 745                 750         


Phe Gln Ile Pro Thr Val Pro Glu Asp Leu Phe Phe Leu Glu Glu Gly 
        755                 760                 765             


Pro Ser Tyr Ala Phe Glu Val Asp Thr Val Ala Pro Glu His Gly Leu 
    770                 775                 780                 


Asp Asn Ala Pro Val Val Asp Gln Gln Leu Leu Tyr Thr Cys Cys Pro 
785                 790                 795                 800 


Tyr Ile Gly Glu Leu Arg Lys Leu Leu Ala Ser Trp Val Ser Gly Ser 
                805                 810                 815     


Ser Gly Arg Ser Gly Gly Phe Met Arg Lys Ile Thr Pro Thr Thr Thr 
            820                 825                 830         


Thr Ser Leu Gly Ala Gln Pro Ser Gln Thr Ser Gln Gly Leu Gln Ala 
        835                 840                 845             


Gln Leu Ala Gln Ala Phe Phe His Asn Gln Pro Pro Ser Leu Arg Arg 
    850                 855                 860                 


Thr Val Glu Phe Val Ala Glu Arg Ile Gly Ser Asn Cys Val Lys His 
865                 870                 875                 880 


Ile Lys Ala Thr Leu Val Ala Asp Leu Val Arg Gln Ala Glu Ser Leu 
                885                 890                 895     


Leu Gln Glu Gln Leu Val Thr Gln Gly Glu Glu Gly Gly Asp Pro Ala 
            900                 905                 910         


Gln Leu Leu Glu Ile Leu Cys Ser Gln Leu Cys Pro His Gly Ala Gln 
        915                 920                 925             


Ala Leu Ala Leu Gly Arg Glu Phe Cys Gln Arg Lys Ser Pro Gly Ala 
    930                 935                 940                 


Val Arg Ala Leu Leu Pro Glu Glu Thr Pro Ala Ala Val Leu Ser Ser 
945                 950                 955                 960 


Ala Glu Asn Ile Ala Val Gly Leu Ala Thr Glu Lys Ala Cys Ala Trp 
                965                 970                 975     


Leu Ser Ala Asn Ile Thr Ala Leu Ile Arg Arg Glu Val Lys Ala Ala 
            980                 985                 990         


Val Ser Arg Thr Leu Arg Ala Gln  Gly Pro Glu Pro Ala  Ala Arg Gly 
        995                 1000                 1005             


Glu Arg  Arg Gly Cys Ser Arg  Ala Cys Glu His His  Ala Pro Leu 
    1010                 1015                 1020             


Pro Ser  His Leu Ile Ser Glu  Ile Lys Asp Val Leu  Ser Leu Ala 
    1025                 1030                 1035             


Val Gly  Pro Arg Asp Pro Asp  Glu Gly Val Ser Pro  Glu His Leu 
    1040                 1045                 1050             


Glu Gln  Leu Leu Gly Gln Leu  Gly Gln Thr Leu Arg  Cys Arg Gln 
    1055                 1060                 1065             


Phe Leu  Cys Pro Pro Ala Glu  Gln His Leu Ala Lys  Cys Ser Val 
    1070                 1075                 1080             


Glu Leu  Ala Ser Leu Leu Val  Ala Asp Gln Ile Pro  Ile Leu Gly 
    1085                 1090                 1095             


Pro Pro  Ala Gln Tyr Arg Leu  Glu Arg Gly Gln Ala  Arg Arg Leu 
    1100                 1105                 1110             


Leu His  Met Leu Leu Ser Leu  Trp Lys Glu Asp Phe  Gln Gly Pro 
    1115                 1120                 1125             


Val Pro  Leu Gln Leu Leu Leu  Ser Pro Arg Asn Val  Gly Leu Leu 
    1130                 1135                 1140             


Ala Asp  Thr Arg Pro Arg Glu  Trp Asp Leu Leu Leu  Phe Leu Leu 
    1145                 1150                 1155             


Arg Glu  Leu Val Glu Lys Gly  Leu Met Gly Arg Met  Glu Ile Glu 
    1160                 1165                 1170             


Ala Cys  Leu Gly Ser Leu His  Gln Ala Gln Trp Pro  Gly Asp Phe 
    1175                 1180                 1185             


Ala Glu  Glu Leu Ala Thr Leu  Ser Asn Leu Phe Leu  Ala Glu Pro 
    1190                 1195                 1200             


His Leu  Pro Glu Pro Gln Leu  Arg Ala Cys Glu Leu  Val Gln Pro 
    1205                 1210                 1215             


Asn Arg  Gly Thr Val Leu Ala  Gln Ser 
    1220                 1225         


<210>  1867
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC123__Homo_sapiens__NP_006014

<400>  1867

Met Lys Lys Glu His Val Leu His Cys Gln Phe Ser Ala Trp Tyr Pro 
1               5                   10                  15      


Phe Phe Arg Gly Val Thr Ile Lys Ser Val Ile Leu Pro Leu Pro Gln 
            20                  25                  30          


Asn Val Lys Asp Tyr Leu Leu Asp Asp Gly Thr Leu Val Val Ser Gly 
        35                  40                  45              


Arg Asp Asp Pro Pro Thr His Ser Gln Pro Asp Ser Asp Asp Glu Ala 
    50                  55                  60                  


Glu Glu Ile Gln Trp Ser Asp Asp Glu Asn Thr Ala Thr Leu Thr Ala 
65                  70                  75                  80  


Pro Glu Phe Pro Glu Phe Ala Thr Lys Val Gln Glu Ala Ile Asn Ser 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Pro Lys Leu Asn Trp Ser Ala Pro Arg Asp 
            100                 105                 110         


Ala Tyr Trp Ile Ala Met Asn Ser Ser Leu Lys Cys Lys Thr Leu Ser 
        115                 120                 125             


Asp Ile Phe Leu Leu Phe Lys Ser Ser Asp Phe Ile Thr Arg Asp Phe 
    130                 135                 140                 


Thr Gln Pro Phe Ile His Cys Thr Asp Asp Ser Pro Asp Pro Cys Ile 
145                 150                 155                 160 


Glu Tyr Glu Leu Val Leu Arg Lys Trp Cys Glu Leu Ile Pro Gly Ala 
                165                 170                 175     


Glu Phe Arg Cys Phe Val Lys Glu Asn Lys Leu Ile Gly Ile Ser Gln 
            180                 185                 190         


Arg Asp Tyr Thr Gln Tyr Tyr Asp His Ile Ser Lys Gln Lys Glu Glu 
        195                 200                 205             


Ile Arg Arg Cys Ile Gln Asp Phe Phe Lys Lys His Ile Gln Tyr Lys 
    210                 215                 220                 


Phe Leu Asp Glu Asp Phe Val Phe Asp Ile Tyr Arg Asp Ser Arg Gly 
225                 230                 235                 240 


Lys Val Trp Leu Ile Asp Phe Asn Pro Phe Gly Glu Val Thr Asp Ser 
                245                 250                 255     


Leu Leu Phe Thr Trp Glu Glu Leu Ile Ser Glu Asn Asn Leu Asn Gly 
            260                 265                 270         


Asp Phe Ser Glu Val Asp Ala Gln Glu Gln Asp Ser Pro Ala Phe Arg 
        275                 280                 285             


Cys Thr Asn Ser Glu Val Thr Val Gln Pro Ser Pro Tyr Leu Ser Tyr 
    290                 295                 300                 


Arg Leu Pro Lys Asp Phe Val Asp Leu Ser Thr Gly Glu Asp Ala His 
305                 310                 315                 320 


Lys Leu Ile Asp Phe Leu Lys Leu Lys Arg Asn Gln Gln Glu Asp Asp 
                325                 330                 335     


<210>  1868
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC14A__Homo_sapiens__XP_011540643

<400>  1868

Met Asp Phe Pro Leu Gly Gln Cys Arg Leu Val Cys Ser Ser Leu Tyr 
1               5                   10                  15      


Met Trp Leu Ala Lys Arg Glu Asp Gly Ala Ala Ile Leu Asn Met Pro 
            20                  25                  30          


Ser Pro Ser Phe Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val 
        35                  40                  45              


Tyr Arg Tyr Cys Cys Lys Leu Asn Lys Lys Leu Lys Ser Tyr Ser Leu 
    50                  55                  60                  


Ser Arg Lys Lys Ile Val His Tyr Thr Cys Phe Asp Gln Arg Lys Arg 
65                  70                  75                  80  


Ala Asn Ala Ala Phe Leu Ile Gly Ala Tyr Ala Val Ile Tyr Leu Lys 
                85                  90                  95      


Lys Thr Pro Glu Glu Ala Tyr Arg Ala Leu Leu Ser Gly Ser Asn Pro 
            100                 105                 110         


Pro Tyr Leu Pro Phe Arg Asp Ala Ser Phe Gly Asn Cys Thr Tyr Asn 
        115                 120                 125             


Leu Thr Ile Leu Asp Cys Leu Gln Gly Ile Arg Lys Gly Leu Gln His 
    130                 135                 140                 


Gly Phe Phe Asp Phe Glu Thr Phe Asp Val Asp Glu Tyr Glu His Tyr 
145                 150                 155                 160 


Glu Arg Val Glu Asn Gly Asp Phe Asn Trp Ile Val Pro Gly Lys Phe 
                165                 170                 175     


Leu Ala Phe Ser Gly Pro His Pro Lys Ser Lys Ile Glu Asn Gly Tyr 
            180                 185                 190         


Pro Leu His Ala Pro Glu Ala Tyr Phe Pro Tyr Phe Lys Lys His Asn 
        195                 200                 205             


Val Thr Ala Val Val Arg Leu Asn Lys Lys Ile Tyr Glu Ala Lys Arg 
    210                 215                 220                 


Phe Thr Asp Ala Gly Phe Glu His Tyr Asp Leu Phe Phe Ile Asp Gly 
225                 230                 235                 240 


Ser Thr Pro Ser Asp Asn Ile Val Arg Arg Phe Leu Asn Ile Cys Glu 
                245                 250                 255     


Asn Thr Glu Gly Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg 
            260                 265                 270         


Thr Gly Thr Leu Ile Ala Cys Tyr Val Met Lys His Tyr Arg Phe Thr 
        275                 280                 285             


His Ala Glu Ile Ile Ala Trp Ile Arg Ile Cys Arg Pro Gly Ser Ile 
    290                 295                 300                 


Ile Gly Pro Gln Gln His Phe Leu Glu Glu Lys Gln Ala Ser Leu Trp 
305                 310                 315                 320 


Val Gln Gly Asp Ile Phe Arg Ser Lys Leu Lys Asn Arg Pro Ser Ser 
                325                 330                 335     


Glu Gly Ser Ile Asn Lys Ile Leu Ser Gly Leu Asp Asp Met Ser Ile 
            340                 345                 350         


Gly Gly Asn Leu Ser Lys Thr Gln Asn Met Glu Arg Phe Gly Glu Asp 
        355                 360                 365             


Asn Leu Glu Asp Asp Asp Val Glu Met Lys Asn Gly Ile Thr Gln Gly 
    370                 375                 380                 


Asp Lys Leu Arg Ala Leu Lys Ser Gln Arg Gln Pro Arg Thr Ser Pro 
385                 390                 395                 400 


Ser Cys Ala Phe Arg Ser Asp Asp Thr Lys Gly His Pro Arg Ala Val 
                405                 410                 415     


Ser Gln Pro Phe Arg Leu Ser Ser Ser Leu Gln Gly Ser Ala Val Thr 
            420                 425                 430         


Leu Lys Thr Ser Lys Met Ala Leu Ser Pro Ser Ala Thr Ala Lys Arg 
        435                 440                 445             


Ile Asn Arg Thr Ser Leu Ser Ser Gly Ala Thr Val Arg Ser Phe Ser 
    450                 455                 460                 


Ile Asn Ser Arg Leu Ala Ser Ser Leu Gly Asn Leu Asn Ala Ala Thr 
465                 470                 475                 480 


Asp Asp Pro Glu Asn Lys Lys Thr Ser Ser Ser Ser Lys Ala Gly Phe 
                485                 490                 495     


Thr Ala Ser Pro Phe Thr Asn Leu Leu Asn Gly Ser Ser Gln Pro Thr 
            500                 505                 510         


Thr Arg Asn Tyr Pro Glu Leu Asn Asn Asn Gln Tyr Asn Arg Ser Ser 
        515                 520                 525             


Asn Ser Asn Gly Gly Asn Leu Asn Ser Pro Pro Gly Pro His Ser Ala 
    530                 535                 540                 


Lys Thr Glu Glu His Thr Thr Ile Leu Arg Pro Ser Tyr Thr Gly Leu 
545                 550                 555                 560 


Ser Ser Ser Ser Ala Arg Phe Leu Ser Arg Ser Ile Pro Val Ser Ala 
                565                 570                 575     


Gln Thr Pro Pro Pro Gly Pro Gln Asn Pro Glu Cys Asn Phe Cys Ala 
            580                 585                 590         


Leu Pro Ser Gln Pro Arg Leu Pro Pro Lys Lys Phe Asn Ser Ala Lys 
        595                 600                 605             


Glu Ala Phe 
    610     


<210>  1869
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC14B__Homo_sapiens__NP_001070649

<400>  1869

Met Ser Arg Glu Gly Ala Gly Ala Ala Leu Val Ala Glu Val Ile Lys 
1               5                   10                  15      


Asp Arg Leu Cys Phe Ala Ile Leu Tyr Ser Arg Pro Lys Ser Ala Ser 
            20                  25                  30          


Asn Val His Tyr Phe Ser Ile Asp Asn Glu Leu Glu Tyr Glu Asn Phe 
        35                  40                  45              


Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr Cys 
    50                  55                  60                  


Cys Lys Ile Asn Lys Lys Leu Lys Ser Ile Thr Met Leu Arg Lys Lys 
65                  70                  75                  80  


Ile Val His Phe Thr Gly Ser Asp Gln Arg Lys Gln Ala Asn Ala Ala 
                85                  90                  95      


Phe Leu Val Gly Cys Tyr Met Val Ile Tyr Leu Gly Arg Thr Pro Glu 
            100                 105                 110         


Glu Ala Tyr Arg Ile Leu Ile Phe Gly Glu Thr Ser Tyr Ile Pro Phe 
        115                 120                 125             


Arg Asp Ala Ala Tyr Gly Ser Cys Asn Phe Tyr Ile Thr Leu Leu Asp 
    130                 135                 140                 


Cys Phe His Ala Val Lys Lys Ala Met Gln Tyr Gly Phe Leu Asn Phe 
145                 150                 155                 160 


Asn Ser Phe Asn Leu Asp Glu Tyr Glu His Tyr Glu Lys Ala Glu Asn 
                165                 170                 175     


Gly Asp Leu Asn Trp Ile Ile Pro Asp Arg Phe Ile Ala Phe Cys Gly 
            180                 185                 190         


Pro His Ser Arg Ala Arg Leu Glu Ser Gly Tyr His Gln His Ser Pro 
        195                 200                 205             


Glu Thr Tyr Ile Gln Tyr Phe Lys Asn His Asn Val Thr Thr Ile Ile 
    210                 215                 220                 


Arg Leu Asn Lys Arg Met Tyr Asp Ala Lys Arg Phe Thr Asp Ala Gly 
225                 230                 235                 240 


Phe Asp His His Asp Leu Phe Phe Ala Asp Gly Ser Thr Pro Thr Asp 
                245                 250                 255     


Ala Ile Val Lys Glu Phe Leu Asp Ile Cys Glu Asn Ala Glu Gly Ala 
            260                 265                 270         


Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu Ile 
        275                 280                 285             


Ala Cys Tyr Ile Met Lys His Tyr Arg Met Thr Ala Ala Glu Thr Ile 
    290                 295                 300                 


Ala Trp Val Arg Ile Cys Arg Pro Gly Ser Val Ile Gly Pro Gln Gln 
305                 310                 315                 320 


Gln Phe Leu Val Met Lys Gln Thr Asn Leu Trp Leu Glu Gly Asp Tyr 
                325                 330                 335     


Phe Arg Gln Lys Leu Lys Gly Gln Glu Asn Gly Gln His Arg Ala Ala 
            340                 345                 350         


Phe Ser Lys Leu Leu Ser Gly Val Asp Asp Ile Ser Ile Asn Gly Val 
        355                 360                 365             


Glu Asn Gln Asp Gln Gln Glu Pro Glu Pro Tyr Ser Asp Asp Asp Glu 
    370                 375                 380                 


Ile Asn Gly Val Thr Gln Gly Asp Arg Leu Arg Ala Leu Lys Ser Arg 
385                 390                 395                 400 


Arg Gln Ser Lys Thr Asn Ala Ile Pro Leu Thr Val Ile Leu Gln Ser 
                405                 410                 415     


Ser Val Gln Ser Cys Lys Thr Ser Glu Pro Asn Ile Ser Gly Ser Ala 
            420                 425                 430         


Gly Ile Thr Lys Arg Thr Thr Arg Ser Ala Ser Arg Lys Ser Ser Val 
        435                 440                 445             


Lys Ser Leu Ser Ile Ser Arg Thr Lys Thr Val Leu Arg 
    450                 455                 460     


<210>  1870
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC16__Homo_sapiens__NP_003894

<400>  1870

Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His 
        355                 360                 365             


Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser 
    370                 375                 380                 


Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu 
385                 390                 395                 400 


Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly 
                405                 410                 415     


Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile 
            420                 425                 430         


Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu 
        435                 440                 445             


Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala 
    450                 455                 460                 


Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser 
465                 470                 475                 480 


Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu 
                485                 490                 495     


Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp 
            500                 505                 510         


Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly 
        515                 520                 525             


Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys 
    530                 535                 540                 


Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser 
545                 550                 555                 560 


Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu 
                565                 570                 575     


Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser 
            580                 585                 590         


Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp 
        595                 600                 605             


Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
    610                 615                 620 


<210>  1871
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC20B__Homo_sapiens__NP_001139206

<400>  1871

Met Glu Trp Lys Leu Glu Arg Thr Ala Pro Arg Arg Val Arg Thr Glu 
1               5                   10                  15      


Glu Glu Met Leu Trp Glu Ser Ile Met Arg Val Leu Ser Lys Asp Leu 
            20                  25                  30          


Lys Gln Lys Arg Ser Gln Asp Ser Ala Asn Val Leu Asp Ser Val Asn 
        35                  40                  45              


Ala Thr Tyr Ser Asp Phe Lys Ser Asn Phe Ala Lys Arg Leu Ser Ala 
    50                  55                  60                  


Glu Val Pro Val Ala Ser Ser Pro Ile Thr Thr Arg Trp Gln Gln Ser 
65                  70                  75                  80  


Gln Thr Arg Ala Leu Ser Ser Asp Ser Phe Gly Glu Glu Gln Ser Thr 
                85                  90                  95      


Thr Tyr Leu Pro Glu Ala Ser Gly Ser Val Leu Lys Thr Pro Pro Glu 
            100                 105                 110         


Lys Glu Thr Leu Thr Leu Gly Ser Arg Lys Glu Gln Leu Lys Thr Pro 
        115                 120                 125             


Ser Lys Gly Ile Ser Glu Thr Ser Asn Ser Ala Leu His Phe Cys Lys 
    130                 135                 140                 


Ala Pro His Ala Met Asp Arg Asp Trp Lys Glu Ser Val Ala Ser Lys 
145                 150                 155                 160 


Gly Gln Lys Cys Leu Lys Gln Leu Phe Val Thr Gln Asn Val Val Gln 
                165                 170                 175     


Gln Ala Asn Gly Lys Met Gln Leu Cys Glu Gln Ser Glu Cys Val Trp 
            180                 185                 190         


Lys Gly Cys Lys Asp Gly Val Arg Asp Glu Ser Phe His Leu Lys Ser 
        195                 200                 205             


Ser Gly Asp Ile Asn Asp Ser Ile Leu Gln Pro Glu Val Lys Ile His 
    210                 215                 220                 


Ile Thr Gly Leu Arg Asn Asp Tyr Tyr Leu Asn Ile Leu Asp Trp Ser 
225                 230                 235                 240 


Phe Gln Asn Leu Val Ala Ile Ala Leu Gly Ser Ala Val Tyr Ile Trp 
                245                 250                 255     


Asn Gly Glu Asn His Asn Gly Ile Glu Asn Ile Asp Leu Ser Leu Thr 
            260                 265                 270         


Cys Asn Tyr Ile Ser Ser Val Ser Trp Ile Lys Glu Gly Thr Cys Leu 
        275                 280                 285             


Ala Val Gly Thr Ser Glu Gly Glu Val Gln Leu Trp Asp Val Val Thr 
    290                 295                 300                 


Lys Lys Arg Leu Arg Asn Met Leu Gly His Leu Ser Val Val Gly Ala 
305                 310                 315                 320 


Leu Ser Trp Asn His Phe Ile Leu Ser Ser Gly Ser Arg Leu Gly Arg 
                325                 330                 335     


Val Tyr His His Asp Val Arg Val Ala Gln His His Val Gly Thr Leu 
            340                 345                 350         


Arg His Lys Gln Ala Val Cys Ala Leu Lys Trp Ser Pro Asp Gly Arg 
        355                 360                 365             


Leu Leu Ser Ser Gly Cys Ser Asp Gly Leu Leu Thr Ile Trp Pro His 
    370                 375                 380                 


Asp Pro Gly Ala Ser Ala Gln Gly Gln Pro Leu Lys Val Ile Thr Gln 
385                 390                 395                 400 


Ser Thr Ala Val Lys Ile Cys Ser Leu Ile Trp Leu Pro Lys Thr Lys 
                405                 410                 415     


Glu Ile Ala Thr Gly Gln Gly Thr Pro Lys Asn Asp Val Thr Val Trp 
            420                 425                 430         


Thr Cys Pro Thr Val Ser Arg Ser Gly Gly Phe Phe Gly His Arg Gly 
        435                 440                 445             


Arg Val Leu His Leu Ser Leu Ser Pro Asp Gln Thr Arg Val Phe Ser 
    450                 455                 460                 


Ala Ala Ala Asp Gly Thr Ala Ser Val Trp Asn Cys Tyr 
465                 470                 475         


<210>  1872
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC23__Homo_sapiens__NP_004652

<400>  1872

Met Ala Ala Ser Thr Ser Met Val Pro Val Ala Val Thr Ala Ala Val 
1               5                   10                  15      


Ala Pro Val Leu Ser Ile Asn Ser Asp Phe Ser Asp Leu Arg Glu Ile 
            20                  25                  30          


Lys Lys Gln Leu Leu Leu Ile Ala Gly Leu Thr Arg Glu Arg Gly Leu 
        35                  40                  45              


Leu His Ser Ser Lys Trp Ser Ala Glu Leu Ala Phe Ser Leu Pro Ala 
    50                  55                  60                  


Leu Pro Leu Ala Glu Leu Gln Pro Pro Pro Pro Ile Thr Glu Glu Asp 
65                  70                  75                  80  


Ala Gln Asp Met Asp Ala Tyr Thr Leu Ala Lys Ala Tyr Phe Asp Val 
                85                  90                  95      


Lys Glu Tyr Asp Arg Ala Ala His Phe Leu His Gly Cys Asn Ser Lys 
            100                 105                 110         


Lys Ala Tyr Phe Leu Tyr Met Tyr Ser Arg Tyr Leu Ser Gly Glu Lys 
        115                 120                 125             


Lys Lys Asp Asp Glu Thr Val Asp Ser Leu Gly Pro Leu Glu Lys Gly 
    130                 135                 140                 


Gln Val Lys Asn Glu Ala Leu Arg Glu Leu Arg Val Glu Leu Ser Lys 
145                 150                 155                 160 


Lys His Gln Ala Arg Glu Leu Asp Gly Phe Gly Leu Tyr Leu Tyr Gly 
                165                 170                 175     


Val Val Leu Arg Lys Leu Asp Leu Val Lys Glu Ala Ile Asp Val Phe 
            180                 185                 190         


Val Glu Ala Thr His Val Leu Pro Leu His Trp Gly Ala Trp Leu Glu 
        195                 200                 205             


Leu Cys Asn Leu Ile Thr Asp Lys Glu Met Leu Lys Phe Leu Ser Leu 
    210                 215                 220                 


Pro Asp Thr Trp Met Lys Glu Phe Phe Leu Ala His Ile Tyr Thr Glu 
225                 230                 235                 240 


Leu Gln Leu Ile Glu Glu Ala Leu Gln Lys Tyr Gln Asn Leu Ile Asp 
                245                 250                 255     


Val Gly Phe Ser Lys Ser Ser Tyr Ile Val Ser Gln Ile Ala Val Ala 
            260                 265                 270         


Tyr His Asn Ile Arg Asp Ile Asp Lys Ala Leu Ser Ile Phe Asn Glu 
        275                 280                 285             


Leu Arg Lys Gln Asp Pro Tyr Arg Ile Glu Asn Met Asp Thr Phe Ser 
    290                 295                 300                 


Asn Leu Leu Tyr Val Arg Ser Met Lys Ser Glu Leu Ser Tyr Leu Ala 
305                 310                 315                 320 


His Asn Leu Cys Glu Ile Asp Lys Tyr Arg Val Glu Thr Cys Cys Val 
                325                 330                 335     


Ile Gly Asn Tyr Tyr Ser Leu Arg Ser Gln His Glu Lys Ala Ala Leu 
            340                 345                 350         


Tyr Phe Gln Arg Ala Leu Lys Leu Asn Pro Arg Tyr Leu Gly Ala Trp 
        355                 360                 365             


Thr Leu Met Gly His Glu Tyr Met Glu Met Lys Asn Thr Ser Ala Ala 
    370                 375                 380                 


Ile Gln Ala Tyr Arg His Ala Ile Glu Val Asn Lys Arg Asp Tyr Arg 
385                 390                 395                 400 


Ala Trp Tyr Gly Leu Gly Gln Thr Tyr Glu Ile Leu Lys Met Pro Phe 
                405                 410                 415     


Tyr Cys Leu Tyr Tyr Tyr Arg Arg Ala His Gln Leu Arg Pro Asn Asp 
            420                 425                 430         


Ser Arg Met Leu Val Ala Leu Gly Glu Cys Tyr Glu Lys Leu Asn Gln 
        435                 440                 445             


Leu Val Glu Ala Lys Lys Cys Tyr Trp Arg Ala Tyr Ala Val Gly Asp 
    450                 455                 460                 


Val Glu Lys Met Ala Leu Val Lys Leu Ala Lys Leu His Glu Gln Leu 
465                 470                 475                 480 


Thr Glu Ser Glu Gln Ala Ala Gln Cys Tyr Ile Lys Tyr Ile Gln Asp 
                485                 490                 495     


Ile Tyr Ser Cys Gly Glu Ile Val Glu His Leu Glu Glu Ser Thr Ala 
            500                 505                 510         


Phe Arg Tyr Leu Ala Gln Tyr Tyr Phe Lys Cys Lys Leu Trp Asp Glu 
        515                 520                 525             


Ala Ser Thr Cys Ala Gln Lys Cys Cys Ala Phe Asn Asp Thr Arg Glu 
    530                 535                 540                 


Glu Gly Lys Ala Leu Leu Arg Gln Ile Leu Gln Leu Arg Asn Gln Gly 
545                 550                 555                 560 


Glu Thr Pro Thr Thr Glu Val Pro Ala Pro Phe Phe Leu Pro Ala Ser 
                565                 570                 575     


Leu Ser Ala Asn Asn Thr Pro Thr Arg Arg Val Ser Pro Leu Asn Leu 
            580                 585                 590         


Ser Ser Val Thr Pro 
        595         


<210>  1873
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC25A__Homo_sapiens__NP_001780

<400>  1873

Met Glu Leu Gly Pro Glu Pro Pro His Arg Arg Arg Leu Leu Phe Ala 
1               5                   10                  15      


Cys Ser Pro Pro Pro Ala Ser Gln Pro Val Val Lys Ala Leu Phe Gly 
            20                  25                  30          


Ala Ser Ala Ala Gly Gly Leu Ser Pro Val Thr Asn Leu Thr Val Thr 
        35                  40                  45              


Met Asp Gln Leu Gln Gly Leu Gly Ser Asp Tyr Glu Gln Pro Leu Glu 
    50                  55                  60                  


Val Lys Asn Asn Ser Asn Leu Gln Arg Met Gly Ser Ser Glu Ser Thr 
65                  70                  75                  80  


Asp Ser Gly Phe Cys Leu Asp Ser Pro Gly Pro Leu Asp Ser Lys Glu 
                85                  90                  95      


Asn Leu Glu Asn Pro Met Arg Arg Ile His Ser Leu Pro Gln Lys Leu 
            100                 105                 110         


Leu Gly Cys Ser Pro Ala Leu Lys Arg Ser His Ser Asp Ser Leu Asp 
        115                 120                 125             


His Asp Ile Phe Gln Leu Ile Asp Pro Asp Glu Asn Lys Glu Asn Glu 
    130                 135                 140                 


Ala Phe Glu Phe Lys Lys Pro Val Arg Pro Val Ser Arg Gly Cys Leu 
145                 150                 155                 160 


His Ser His Gly Leu Gln Glu Gly Lys Asp Leu Phe Thr Gln Arg Gln 
                165                 170                 175     


Asn Ser Ala Pro Ala Arg Met Leu Ser Ser Asn Glu Arg Asp Ser Ser 
            180                 185                 190         


Glu Pro Gly Asn Phe Ile Pro Leu Phe Thr Pro Gln Ser Pro Val Thr 
        195                 200                 205             


Ala Thr Leu Ser Asp Glu Asp Asp Gly Phe Val Asp Leu Leu Asp Gly 
    210                 215                 220                 


Glu Asn Leu Lys Asn Glu Glu Glu Thr Pro Ser Cys Met Ala Ser Leu 
225                 230                 235                 240 


Trp Thr Ala Pro Leu Val Met Arg Thr Thr Asn Leu Asp Asn Arg Cys 
                245                 250                 255     


Lys Leu Phe Asp Ser Pro Ser Leu Cys Ser Ser Ser Thr Arg Ser Val 
            260                 265                 270         


Leu Lys Arg Pro Glu Arg Ser Gln Glu Glu Ser Pro Pro Gly Ser Thr 
        275                 280                 285             


Lys Arg Arg Lys Ser Met Ser Gly Ala Ser Pro Lys Glu Ser Thr Asn 
    290                 295                 300                 


Pro Glu Lys Ala His Glu Thr Leu His Gln Ser Leu Ser Leu Ala Ser 
305                 310                 315                 320 


Ser Pro Lys Gly Thr Ile Glu Asn Ile Leu Asp Asn Asp Pro Arg Asp 
                325                 330                 335     


Leu Ile Gly Asp Phe Ser Lys Gly Tyr Leu Phe His Thr Val Ala Gly 
            340                 345                 350         


Lys His Gln Asp Leu Lys Tyr Ile Ser Pro Glu Ile Met Ala Ser Val 
        355                 360                 365             


Leu Asn Gly Lys Phe Ala Asn Leu Ile Lys Glu Phe Val Ile Ile Asp 
    370                 375                 380                 


Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly Gly His Ile Lys Gly Ala Val 
385                 390                 395                 400 


Asn Leu His Met Glu Glu Glu Val Glu Asp Phe Leu Leu Lys Lys Pro 
                405                 410                 415     


Ile Val Pro Thr Asp Gly Lys Arg Val Ile Val Val Phe His Cys Glu 
            420                 425                 430         


Phe Ser Ser Glu Arg Gly Pro Arg Met Cys Arg Tyr Val Arg Glu Arg 
        435                 440                 445             


Asp Arg Leu Gly Asn Glu Tyr Pro Lys Leu His Tyr Pro Glu Leu Tyr 
    450                 455                 460                 


Val Leu Lys Gly Gly Tyr Lys Glu Phe Phe Met Lys Cys Gln Ser Tyr 
465                 470                 475                 480 


Cys Glu Pro Pro Ser Tyr Arg Pro Met His His Glu Asp Phe Lys Glu 
                485                 490                 495     


Asp Leu Lys Lys Phe Arg Thr Lys Ser Arg Thr Trp Ala Gly Glu Lys 
            500                 505                 510         


Ser Lys Arg Glu Met Tyr Ser Arg Leu Lys Lys Leu 
        515                 520                 


<210>  1874
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC25B__Homo_sapiens__NP_001274445

<400>  1874

Met His Ser Glu Thr Pro Lys Ser Gln Val Gly Thr Leu Leu Phe Arg 
1               5                   10                  15      


Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala Ser Glu 
            20                  25                  30          


Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly Leu Cys 
        35                  40                  45              


Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln Thr Phe 
    50                  55                  60                  


Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu Gln Phe 
65                  70                  75                  80  


Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly His Ser 
                85                  90                  95      


Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly Arg Arg 
            100                 105                 110         


Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu Asp Lys 
        115                 120                 125             


Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro 
    130                 135                 140                 


Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe 
145                 150                 155                 160 


Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp 
                165                 170                 175     


Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe 
            180                 185                 190         


Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val 
        195                 200                 205             


Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro Pro Gly 
    210                 215                 220                 


Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu Lys Glu 
225                 230                 235                 240 


Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe Arg 
                245                 250                 255     


Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg Leu 
            260                 265                 270         


Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg Arg 
        275                 280                 285             


Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro Lys Ala 
    290                 295                 300                 


Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu Asn Leu 
305                 310                 315                 320 


Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys Ala Phe 
                325                 330                 335     


Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr Ile Ser 
            340                 345                 350         


Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn Ile Val 
        355                 360                 365             


Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly 
    370                 375                 380                 


Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp Ala Glu 
385                 390                 395                 400 


Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp Lys Arg 
                405                 410                 415     


Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg 
            420                 425                 430         


Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp Tyr Pro 
        435                 440                 445             


Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr Lys Glu 
    450                 455                 460                 


Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr Arg Pro 
465                 470                 475                 480 


Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg Leu Lys 
                485                 490                 495     


Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys Ser Arg 
            500                 505                 510         


Leu Gln Asp Gln 
        515     


<210>  1875
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC25C__Homo_sapiens__NP_001274511

<400>  1875

Met Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Thr 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Thr Pro Lys Arg Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp Leu Asp Glu Thr 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Ser Pro Ala Gln Leu Leu Cys 
        115                 120                 125             


Ser Thr Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met 
    130                 135                 140                 


Cys Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 
145                 150                 155                 160 


Ser Glu Met Lys Tyr Leu Gly Ser Pro Ile Thr Thr Val Pro Lys Leu 
                165                 170                 175     


Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Ser Asp 
            180                 185                 190         


Glu Leu Met Glu Phe Ser Leu Lys Asp Gln Glu Ala Lys Val Ser Arg 
        195                 200                 205             


Ser Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn Leu Asn Arg Pro 
    210                 215                 220                 


Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Thr Ile Pro Asp Lys 
225                 230                 235                 240 


Val Lys Lys Lys Tyr Phe Ser Gly Gln Gly Lys Leu Arg Lys Gly Leu 
                245                 250                 255     


Cys Leu Lys Lys Thr Val Ser Leu Cys Asp Ile Thr Ile Thr Gln Met 
            260                 265                 270         


Leu Glu Glu Asp Ser Asn Gln Gly His Leu Ile Gly Asp Phe Ser Lys 
        275                 280                 285             


Val Cys Ala Leu Pro Thr Val Ser Gly Lys His Gln Asp Leu Lys Tyr 
    290                 295                 300                 


Val Asn Pro Glu Thr Val Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly 
305                 310                 315                 320 


Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro Tyr Glu Tyr 
                325                 330                 335     


Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu Tyr Ser Gln Glu Glu 
            340                 345                 350         


Leu Phe Asn Phe Phe Leu Lys Lys Pro Ile Val Pro Leu Asp Thr Gln 
        355                 360                 365             


Lys Arg Ile Ile Ile Val Phe His Cys Glu Phe Ser Ser Glu Arg Gly 
    370                 375                 380                 


Pro Arg Met Cys Arg Cys Leu Arg Glu Glu Asp Arg Ser Leu Asn Gln 
385                 390                 395                 400 


Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr 
                405                 410                 415     


Arg Asp Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr 
            420                 425                 430         


Cys Pro Met His His Gln Asp His Lys Thr Glu Leu Leu Arg Cys Arg 
        435                 440                 445             


Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg Glu Gln Ile 
    450                 455                 460                 


Ala Leu Leu Val Lys Asp Met Ser Pro 
465                 470             


<210>  1876
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC27__Homo_sapiens__NP_001107563

<400>  1876

Met Thr Val Leu Gln Glu Pro Val Gln Ala Ala Ile Trp Gln Ala Leu 
1               5                   10                  15      


Asn His Tyr Ala Tyr Arg Asp Ala Val Phe Leu Ala Glu Arg Leu Tyr 
            20                  25                  30          


Ala Glu Val His Ser Glu Glu Ala Leu Phe Leu Leu Ala Thr Cys Tyr 
        35                  40                  45              


Tyr Arg Ser Gly Lys Ala Tyr Lys Ala Tyr Arg Leu Leu Lys Gly His 
    50                  55                  60                  


Ser Cys Thr Thr Pro Gln Cys Lys Tyr Leu Leu Ala Lys Cys Cys Val 
65                  70                  75                  80  


Asp Leu Ser Lys Leu Ala Glu Gly Glu Gln Ile Leu Ser Gly Gly Val 
                85                  90                  95      


Phe Asn Lys Gln Lys Ser His Asp Asp Ile Val Thr Glu Phe Gly Asp 
            100                 105                 110         


Ser Ala Cys Phe Thr Leu Ser Leu Leu Gly His Val Tyr Cys Lys Thr 
        115                 120                 125             


Asp Arg Leu Ala Lys Gly Ser Glu Cys Tyr Gln Lys Ser Leu Ser Leu 
    130                 135                 140                 


Asn Pro Phe Leu Trp Ser Pro Phe Glu Ser Leu Cys Glu Ile Gly Glu 
145                 150                 155                 160 


Lys Pro Asp Pro Asp Gln Thr Phe Lys Phe Thr Ser Leu Gln Asn Phe 
                165                 170                 175     


Ser Asn Cys Leu Pro Asn Ser Cys Thr Thr Gln Val Pro Asn His Ser 
            180                 185                 190         


Leu Ser His Arg Gln Pro Glu Thr Val Leu Thr Glu Thr Pro Gln Asp 
        195                 200                 205             


Thr Ile Glu Leu Asn Arg Leu Asn Leu Glu Ser Ser Asn Ser Lys Tyr 
    210                 215                 220                 


Ser Leu Asn Thr Asp Ser Ser Val Ser Tyr Ile Asp Ser Ala Val Ile 
225                 230                 235                 240 


Ser Pro Asp Thr Val Pro Leu Gly Thr Gly Thr Ser Ile Leu Ser Lys 
                245                 250                 255     


Gln Val Gln Asn Lys Pro Lys Thr Gly Arg Ser Leu Leu Gly Gly Pro 
            260                 265                 270         


Ala Ala Leu Ser Pro Leu Thr Pro Ser Phe Gly Ile Leu Pro Leu Glu 
        275                 280                 285             


Thr Pro Ser Pro Gly Asp Gly Ser Tyr Leu Gln Asn Tyr Thr Asn Thr 
    290                 295                 300                 


Pro Pro Val Ile Asp Val Pro Ser Thr Gly Ala Pro Ser Lys Lys Thr 
305                 310                 315                 320 


Phe Arg Val Leu Gln Ser Val Ala Arg Ile Gly Gln Thr Gly Thr Lys 
                325                 330                 335     


Ser Val Phe Ser Gln Ser Gly Asn Ser Arg Glu Val Thr Pro Ile Leu 
            340                 345                 350         


Ala Gln Thr Gln Ser Ser Gly Pro Gln Thr Ser Thr Thr Pro Gln Val 
        355                 360                 365             


Leu Ser Pro Thr Ile Thr Ser Pro Pro Asn Ala Leu Pro Arg Arg Ser 
    370                 375                 380                 


Ser Arg Leu Phe Thr Ser Asp Ser Ser Thr Thr Lys Glu Asn Ser Lys 
385                 390                 395                 400 


Lys Leu Lys Met Lys Phe Pro Pro Lys Ile Pro Asn Arg Lys Thr Lys 
                405                 410                 415     


Ser Lys Thr Asn Lys Gly Gly Ile Thr Gln Pro Asn Ile Asn Asp Ser 
            420                 425                 430         


Leu Glu Ile Thr Lys Leu Asp Ser Ser Ile Ile Ser Glu Gly Lys Ile 
        435                 440                 445             


Ser Thr Ile Thr Pro Gln Ile Gln Ala Phe Asn Leu Gln Lys Ala Ala 
    450                 455                 460                 


Ala Glu Gly Leu Met Ser Leu Leu Arg Glu Met Gly Lys Gly Tyr Leu 
465                 470                 475                 480 


Ala Leu Cys Ser Tyr Asn Cys Lys Glu Ala Ile Asn Ile Leu Ser His 
                485                 490                 495     


Leu Pro Ser His His Tyr Asn Thr Gly Trp Val Leu Cys Gln Ile Gly 
            500                 505                 510         


Arg Ala Tyr Phe Glu Leu Ser Glu Tyr Met Gln Ala Glu Arg Ile Phe 
        515                 520                 525             


Ser Glu Val Arg Arg Ile Glu Asn Tyr Arg Val Glu Gly Met Glu Ile 
    530                 535                 540                 


Tyr Ser Thr Thr Leu Trp His Leu Gln Lys Asp Val Ala Leu Ser Val 
545                 550                 555                 560 


Leu Ser Lys Asp Leu Thr Asp Met Asp Lys Asn Ser Pro Glu Ala Trp 
                565                 570                 575     


Cys Ala Ala Gly Asn Cys Phe Ser Leu Gln Arg Glu His Asp Ile Ala 
            580                 585                 590         


Ile Lys Phe Phe Gln Arg Ala Ile Gln Val Asp Pro Asn Tyr Ala Tyr 
        595                 600                 605             


Ala Tyr Thr Leu Leu Gly His Glu Phe Val Leu Thr Glu Glu Leu Asp 
    610                 615                 620                 


Lys Ala Leu Ala Cys Phe Arg Asn Ala Ile Arg Val Asn Pro Arg His 
625                 630                 635                 640 


Tyr Asn Ala Trp Tyr Gly Leu Gly Met Ile Tyr Tyr Lys Gln Glu Lys 
                645                 650                 655     


Phe Ser Leu Ala Glu Met His Phe Gln Lys Ala Leu Asp Ile Asn Pro 
            660                 665                 670         


Gln Ser Ser Val Leu Leu Cys His Ile Gly Val Val Gln His Ala Leu 
        675                 680                 685             


Lys Lys Ser Glu Lys Ala Leu Asp Thr Leu Asn Lys Ala Ile Val Ile 
    690                 695                 700                 


Asp Pro Lys Asn Pro Leu Cys Lys Phe His Arg Ala Ser Val Leu Phe 
705                 710                 715                 720 


Ala Asn Glu Lys Tyr Lys Ser Ala Leu Gln Glu Leu Glu Glu Leu Lys 
                725                 730                 735     


Gln Ile Val Pro Lys Glu Ser Leu Val Tyr Phe Leu Ile Gly Lys Val 
            740                 745                 750         


Tyr Lys Lys Leu Gly Gln Thr His Leu Ala Leu Met Asn Phe Ser Trp 
        755                 760                 765             


Ala Met Asp Leu Asp Pro Lys Gly Ala Asn Asn Gln Ile Lys Glu Ala 
    770                 775                 780                 


Ile Asp Lys Arg Tyr Leu Pro Asp Asp Glu Glu Pro Ile Thr Gln Glu 
785                 790                 795                 800 


Glu Gln Ile Met Gly Thr Asp Glu Ser Gln Glu Ser Ser Met Thr Asp 
                805                 810                 815     


Ala Asp Asp Thr Gln Leu His Ala Ala Glu Ser Asp Glu Phe 
            820                 825                 830 


<210>  1877
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC34__Homo_sapiens__NP_004350

<400>  1877

Met Ala Arg Pro Leu Val Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu 
1               5                   10                  15      


Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Val Thr Leu 
            20                  25                  30          


Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 
        35                  40                  45              


Pro Asn Thr Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe 
    50                  55                  60                  


Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Thr Lys 
65                  70                  75                  80  


Met Trp His Pro Asn Ile Tyr Glu Thr Gly Asp Val Cys Ile Ser Ile 
                85                  90                  95      


Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 
            100                 105                 110         


Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu Ser Val Ile 
        115                 120                 125             


Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn Val Asp Ala 
    130                 135                 140                 


Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu 
145                 150                 155                 160 


Tyr Thr Asp Ile Ile Arg Lys Gln Val Leu Gly Thr Lys Val Asp Ala 
                165                 170                 175     


Glu Arg Asp Gly Val Lys Val Pro Thr Thr Leu Ala Glu Tyr Cys Val 
            180                 185                 190         


Lys Thr Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp 
        195                 200                 205             


Asp Tyr Tyr Glu Asp Gly Glu Val Glu Glu Glu Ala Asp Ser Cys Phe 
    210                 215                 220                 


Gly Asp Asp Glu Asp Asp Ser Gly Thr Glu Glu Ser 
225                 230                 235     


<210>  1878
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC37__Homo_sapiens__NP_008996

<400>  1878

Met Val Asp Tyr Ser Val Trp Asp His Ile Glu Val Ser Asp Asp Glu 
1               5                   10                  15      


Asp Glu Thr His Pro Asn Ile Asp Thr Ala Ser Leu Phe Arg Trp Arg 
            20                  25                  30          


His Gln Ala Arg Val Glu Arg Met Glu Gln Phe Gln Lys Glu Lys Glu 
        35                  40                  45              


Glu Leu Asp Arg Gly Cys Arg Glu Cys Lys Arg Lys Val Ala Glu Cys 
    50                  55                  60                  


Gln Arg Lys Leu Lys Glu Leu Glu Val Ala Glu Gly Gly Lys Ala Glu 
65                  70                  75                  80  


Leu Glu Arg Leu Gln Ala Glu Ala Gln Gln Leu Arg Lys Glu Glu Arg 
                85                  90                  95      


Ser Trp Glu Gln Lys Leu Glu Glu Met Arg Lys Lys Glu Lys Ser Met 
            100                 105                 110         


Pro Trp Asn Val Asp Thr Leu Ser Lys Asp Gly Phe Ser Lys Ser Met 
        115                 120                 125             


Val Asn Thr Lys Pro Glu Lys Thr Glu Glu Asp Ser Glu Glu Val Arg 
    130                 135                 140                 


Glu Gln Lys His Lys Thr Phe Val Glu Lys Tyr Glu Lys Gln Ile Lys 
145                 150                 155                 160 


His Phe Gly Met Leu Arg Arg Trp Asp Asp Ser Gln Lys Tyr Leu Ser 
                165                 170                 175     


Asp Asn Val His Leu Val Cys Glu Glu Thr Ala Asn Tyr Leu Val Ile 
            180                 185                 190         


Trp Cys Ile Asp Leu Glu Val Glu Glu Lys Cys Ala Leu Met Glu Gln 
        195                 200                 205             


Val Ala His Gln Thr Ile Val Met Gln Phe Ile Leu Glu Leu Ala Lys 
    210                 215                 220                 


Ser Leu Lys Val Asp Pro Arg Ala Cys Phe Arg Gln Phe Phe Thr Lys 
225                 230                 235                 240 


Ile Lys Thr Ala Asp Arg Gln Tyr Met Glu Gly Phe Asn Asp Glu Leu 
                245                 250                 255     


Glu Ala Phe Lys Glu Arg Val Arg Gly Arg Ala Lys Leu Arg Ile Glu 
            260                 265                 270         


Lys Ala Met Lys Glu Tyr Glu Glu Glu Glu Arg Lys Lys Arg Leu Gly 
        275                 280                 285             


Pro Gly Gly Leu Asp Pro Val Glu Val Tyr Glu Ser Leu Pro Glu Glu 
    290                 295                 300                 


Leu Gln Lys Cys Phe Asp Val Lys Asp Val Gln Met Leu Gln Asp Ala 
305                 310                 315                 320 


Ile Ser Lys Met Asp Pro Thr Asp Ala Lys Tyr His Met Gln Arg Cys 
                325                 330                 335     


Ile Asp Ser Gly Leu Trp Val Pro Asn Ser Lys Ala Ser Glu Ala Lys 
            340                 345                 350         


Glu Gly Glu Glu Ala Gly Pro Gly Asp Pro Leu Leu Glu Ala Val Pro 
        355                 360                 365             


Lys Thr Gly Asp Glu Lys Asp Val Ser Val 
    370                 375             


<210>  1879
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC37L1__Homo_sapiens__NP_060383

<400>  1879

Met Glu Gln Pro Trp Pro Pro Pro Gly Pro Trp Ser Leu Pro Arg Ala 
1               5                   10                  15      


Glu Gly Glu Ala Glu Glu Glu Ser Asp Phe Asp Val Phe Pro Ser Ser 
            20                  25                  30          


Pro Arg Cys Pro Gln Leu Pro Gly Gly Gly Ala Gln Met Tyr Ser His 
        35                  40                  45              


Gly Ile Glu Leu Ala Cys Gln Lys Gln Lys Glu Phe Val Lys Ser Ser 
    50                  55                  60                  


Val Ala Cys Lys Trp Asn Leu Ala Glu Ala Gln Gln Lys Leu Gly Ser 
65                  70                  75                  80  


Leu Ala Leu His Asn Ser Glu Ser Leu Asp Gln Glu His Ala Lys Ala 
                85                  90                  95      


Gln Thr Ala Val Ser Glu Leu Arg Gln Arg Glu Glu Glu Trp Arg Gln 
            100                 105                 110         


Lys Glu Glu Ala Leu Val Gln Arg Glu Lys Met Cys Leu Trp Ser Thr 
        115                 120                 125             


Asp Ala Ile Ser Lys Asp Val Phe Asn Lys Ser Phe Ile Asn Gln Asp 
    130                 135                 140                 


Lys Arg Lys Asp Thr Glu Asp Glu Asp Lys Ser Glu Ser Phe Met Gln 
145                 150                 155                 160 


Lys Tyr Glu Gln Lys Ile Arg His Phe Gly Met Leu Ser Arg Trp Asp 
                165                 170                 175     


Asp Ser Gln Arg Phe Leu Ser Asp His Pro Tyr Leu Val Cys Glu Glu 
            180                 185                 190         


Thr Ala Lys Tyr Leu Ile Leu Trp Cys Phe His Leu Glu Ala Glu Lys 
        195                 200                 205             


Lys Gly Ala Leu Met Glu Gln Ile Ala His Gln Ala Val Val Met Gln 
    210                 215                 220                 


Phe Ile Met Glu Met Ala Lys Asn Cys Asn Val Asp Pro Arg Gly Cys 
225                 230                 235                 240 


Phe Arg Leu Phe Phe Gln Lys Ala Lys Ala Glu Glu Glu Gly Tyr Phe 
                245                 250                 255     


Glu Ala Phe Lys Asn Glu Leu Glu Ala Phe Lys Ser Arg Val Arg Leu 
            260                 265                 270         


Tyr Ser Gln Ser Gln Ser Phe Gln Pro Met Thr Val Gln Asn His Val 
        275                 280                 285             


Pro His Ser Gly Val Gly Ser Ile Gly Leu Leu Glu Ser Leu Pro Gln 
    290                 295                 300                 


Asn Pro Asp Tyr Leu Gln Tyr Ser Ile Ser Thr Ala Leu Cys Ser Leu 
305                 310                 315                 320 


Asn Ser Val Val His Lys Glu Asp Asp Glu Pro Lys Met Met Asp Thr 
                325                 330                 335     


Val 
    


<210>  1880
<211>  1719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC42BPA__Homo_sapiens__NP_003598

<400>  1880

Met Ser Gly Glu Val Arg Leu Arg Gln Leu Glu Gln Phe Ile Leu Asp 
1               5                   10                  15      


Gly Pro Ala Gln Thr Asn Gly Gln Cys Phe Ser Val Glu Thr Leu Leu 
            20                  25                  30          


Asp Ile Leu Ile Cys Leu Tyr Asp Glu Cys Asn Asn Ser Pro Leu Arg 
        35                  40                  45              


Arg Glu Lys Asn Ile Leu Glu Tyr Leu Glu Trp Ala Lys Pro Phe Thr 
    50                  55                  60                  


Ser Lys Val Lys Gln Met Arg Leu His Arg Glu Asp Phe Glu Ile Leu 
65                  70                  75                  80  


Lys Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Leu 
                85                  90                  95      


Lys Asn Ala Asp Lys Val Phe Ala Met Lys Ile Leu Asn Lys Trp Glu 
            100                 105                 110         


Met Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val 
        115                 120                 125             


Leu Val Asn Gly Asp Asn Lys Trp Ile Thr Thr Leu His Tyr Ala Phe 
    130                 135                 140                 


Gln Asp Asp Asn Asn Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly 
145                 150                 155                 160 


Asp Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Arg Leu Pro Glu Asp 
                165                 170                 175     


Met Ala Arg Phe Tyr Leu Ala Glu Met Val Ile Ala Ile Asp Ser Val 
            180                 185                 190         


His Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Ile Leu 
        195                 200                 205             


Met Asp Met Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu 
    210                 215                 220                 


Lys Leu Met Glu Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr 
225                 230                 235                 240 


Pro Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Lys 
                245                 250                 255     


Gly Arg Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met 
            260                 265                 270         


Tyr Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val 
        275                 280                 285             


Glu Thr Tyr Gly Lys Ile Met Asn His Lys Glu Arg Phe Gln Phe Pro 
    290                 295                 300                 


Ala Gln Val Thr Asp Val Ser Glu Asn Ala Lys Asp Leu Ile Arg Arg 
305                 310                 315                 320 


Leu Ile Cys Ser Arg Glu His Arg Leu Gly Gln Asn Gly Ile Glu Asp 
                325                 330                 335     


Phe Lys Lys His Pro Phe Phe Ser Gly Ile Asp Trp Asp Asn Ile Arg 
            340                 345                 350         


Asn Cys Glu Ala Pro Tyr Ile Pro Glu Val Ser Ser Pro Thr Asp Thr 
        355                 360                 365             


Ser Asn Phe Asp Val Asp Asp Asp Cys Leu Lys Asn Ser Glu Thr Met 
    370                 375                 380                 


Pro Pro Pro Thr His Thr Ala Phe Ser Gly His His Leu Pro Phe Val 
385                 390                 395                 400 


Gly Phe Thr Tyr Thr Ser Ser Cys Val Leu Ser Asp Arg Ser Cys Leu 
                405                 410                 415     


Arg Val Thr Ala Gly Pro Thr Ser Leu Asp Leu Asp Val Asn Val Gln 
            420                 425                 430         


Arg Thr Leu Asp Asn Asn Leu Ala Thr Glu Ala Tyr Glu Arg Arg Ile 
        435                 440                 445             


Lys Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu 
    450                 455                 460                 


Ser Thr Gln Thr Val Gln Ala Leu Gln Tyr Ser Thr Val Asp Gly Pro 
465                 470                 475                 480 


Leu Thr Ala Ser Lys Asp Leu Glu Ile Lys Asn Leu Lys Glu Glu Ile 
                485                 490                 495     


Glu Lys Leu Arg Lys Gln Val Thr Glu Ser Ser His Leu Glu Gln Gln 
            500                 505                 510         


Leu Glu Glu Ala Asn Ala Val Arg Gln Glu Leu Asp Asp Ala Phe Arg 
        515                 520                 525             


Gln Ile Lys Ala Tyr Glu Lys Gln Ile Lys Thr Leu Gln Gln Glu Arg 
    530                 535                 540                 


Glu Asp Leu Asn Lys Glu Leu Val Gln Ala Ser Glu Arg Leu Lys Asn 
545                 550                 555                 560 


Gln Ser Lys Glu Leu Lys Asp Ala His Cys Gln Arg Lys Leu Ala Met 
                565                 570                 575     


Gln Glu Phe Met Glu Ile Asn Glu Arg Leu Thr Glu Leu His Thr Gln 
            580                 585                 590         


Lys Gln Lys Leu Ala Arg His Val Arg Asp Lys Glu Glu Glu Val Asp 
        595                 600                 605             


Leu Val Met Gln Lys Val Glu Ser Leu Arg Gln Glu Leu Arg Arg Thr 
    610                 615                 620                 


Glu Arg Ala Lys Lys Glu Leu Glu Val His Thr Glu Ala Leu Ala Ala 
625                 630                 635                 640 


Glu Ala Ser Lys Asp Arg Lys Leu Arg Glu Gln Ser Glu His Tyr Ser 
                645                 650                 655     


Lys Gln Leu Glu Asn Glu Leu Glu Gly Leu Lys Gln Lys Gln Ile Ser 
            660                 665                 670         


Tyr Ser Pro Gly Val Cys Ser Ile Glu His Gln Gln Glu Ile Thr Lys 
        675                 680                 685             


Leu Lys Thr Asp Leu Glu Lys Lys Ser Ile Phe Tyr Glu Glu Glu Leu 
    690                 695                 700                 


Ser Lys Arg Glu Gly Ile His Ala Asn Glu Ile Lys Asn Leu Lys Lys 
705                 710                 715                 720 


Glu Leu His Asp Ser Glu Gly Gln Gln Leu Ala Leu Asn Lys Glu Ile 
                725                 730                 735     


Met Ile Leu Lys Asp Lys Leu Glu Lys Thr Arg Arg Glu Ser Gln Ser 
            740                 745                 750         


Glu Arg Glu Glu Phe Glu Ser Glu Phe Lys Gln Gln Tyr Glu Arg Glu 
        755                 760                 765             


Lys Val Leu Leu Thr Glu Glu Asn Lys Lys Leu Thr Ser Glu Leu Asp 
    770                 775                 780                 


Lys Leu Thr Thr Leu Tyr Glu Asn Leu Ser Ile His Asn Gln Gln Leu 
785                 790                 795                 800 


Glu Glu Glu Val Lys Asp Leu Ala Asp Lys Lys Glu Ser Val Ala His 
                805                 810                 815     


Trp Glu Ala Gln Ile Thr Glu Ile Ile Gln Trp Val Ser Asp Glu Lys 
            820                 825                 830         


Asp Ala Arg Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu 
        835                 840                 845             


Leu Glu Ala Leu Arg Asn Ser Ser Leu Gly Thr Arg Ala Thr Asp Met 
    850                 855                 860                 


Pro Trp Lys Met Arg Arg Phe Ala Lys Leu Asp Met Ser Ala Arg Leu 
865                 870                 875                 880 


Glu Leu Gln Ser Ala Leu Asp Ala Glu Ile Arg Ala Lys Gln Ala Ile 
                885                 890                 895     


Gln Glu Glu Leu Asn Lys Val Lys Ala Ser Asn Ile Ile Thr Glu Cys 
            900                 905                 910         


Lys Leu Lys Asp Ser Glu Lys Lys Asn Leu Glu Leu Leu Ser Glu Ile 
        915                 920                 925             


Glu Gln Leu Ile Lys Asp Thr Glu Glu Leu Arg Ser Glu Lys Gly Ile 
    930                 935                 940                 


Glu His Gln Asp Ser Gln His Ser Phe Leu Ala Phe Leu Asn Thr Pro 
945                 950                 955                 960 


Thr Asp Ala Leu Asp Gln Phe Glu Thr Val Asp Ser Thr Pro Leu Ser 
                965                 970                 975     


Val His Thr Pro Thr Leu Arg Lys Lys Gly Cys Pro Gly Ser Thr Gly 
            980                 985                 990         


Phe Pro Pro Lys Arg Lys Thr His  Gln Phe Phe Val Lys  Ser Phe Thr 
        995                 1000                 1005             


Thr Pro  Thr Lys Cys His Gln  Cys Thr Ser Leu Met  Val Gly Leu 
    1010                 1015                 1020             


Ile Arg  Gln Gly Cys Ser Cys  Glu Val Cys Gly Phe  Ser Cys His 
    1025                 1030                 1035             


Ile Thr  Cys Val Asn Lys Ala  Pro Thr Thr Cys Pro  Val Pro Pro 
    1040                 1045                 1050             


Glu Gln  Thr Lys Gly Pro Leu  Gly Ile Asp Pro Gln  Lys Gly Ile 
    1055                 1060                 1065             


Gly Thr  Ala Tyr Glu Gly His  Val Arg Ile Pro Lys  Pro Ala Gly 
    1070                 1075                 1080             


Val Lys  Lys Gly Trp Gln Arg  Ala Leu Ala Ile Val  Cys Asp Phe 
    1085                 1090                 1095             


Lys Leu  Phe Leu Tyr Asp Ile  Ala Glu Gly Lys Ala  Ser Gln Pro 
    1100                 1105                 1110             


Ser Val  Val Ile Ser Gln Val  Ile Asp Met Arg Asp  Glu Glu Phe 
    1115                 1120                 1125             


Ser Val  Ser Ser Val Leu Ala  Ser Asp Val Ile His  Ala Ser Arg 
    1130                 1135                 1140             


Lys Asp  Ile Pro Cys Ile Phe  Arg Val Thr Ala Ser  Gln Leu Ser 
    1145                 1150                 1155             


Ala Ser  Asn Asn Lys Cys Ser  Ile Leu Met Leu Ala  Asp Thr Glu 
    1160                 1165                 1170             


Asn Glu  Lys Asn Lys Trp Val  Gly Val Leu Ser Glu  Leu His Lys 
    1175                 1180                 1185             


Ile Leu  Lys Lys Asn Lys Phe  Arg Asp Arg Ser Val  Tyr Val Pro 
    1190                 1195                 1200             


Lys Glu  Ala Tyr Asp Ser Thr  Leu Pro Leu Ile Lys  Thr Thr Gln 
    1205                 1210                 1215             


Ala Ala  Ala Ile Ile Asp His  Glu Arg Ile Ala Leu  Gly Asn Glu 
    1220                 1225                 1230             


Glu Gly  Leu Phe Val Val His  Val Thr Lys Asp Glu  Ile Ile Arg 
    1235                 1240                 1245             


Val Gly  Asp Asn Lys Lys Ile  His Gln Ile Glu Leu  Ile Pro Asn 
    1250                 1255                 1260             


Asp Gln  Leu Val Ala Val Ile  Ser Gly Arg Asn Arg  His Val Arg 
    1265                 1270                 1275             


Leu Phe  Pro Met Ser Ala Leu  Asp Gly Arg Glu Thr  Asp Phe Tyr 
    1280                 1285                 1290             


Lys Leu  Ser Glu Thr Lys Gly  Cys Gln Thr Val Thr  Ser Gly Lys 
    1295                 1300                 1305             


Val Arg  His Gly Ala Leu Thr  Cys Leu Cys Val Ala  Met Lys Arg 
    1310                 1315                 1320             


Gln Val  Leu Cys Tyr Glu Leu  Phe Gln Ser Lys Thr  Arg His Arg 
    1325                 1330                 1335             


Lys Phe  Lys Glu Ile Gln Val  Pro Tyr Asn Val Gln  Trp Met Ala 
    1340                 1345                 1350             


Ile Phe  Ser Glu Gln Leu Cys  Val Gly Phe Gln Ser  Gly Phe Leu 
    1355                 1360                 1365             


Arg Tyr  Pro Leu Asn Gly Glu  Gly Asn Pro Tyr Ser  Met Leu His 
    1370                 1375                 1380             


Ser Asn  Asp His Thr Leu Ser  Phe Ile Ala His Gln  Pro Met Asp 
    1385                 1390                 1395             


Ala Ile  Cys Ala Val Glu Ile  Ser Ser Lys Glu Tyr  Leu Leu Cys 
    1400                 1405                 1410             


Phe Asn  Ser Ile Gly Ile Tyr  Thr Asp Cys Gln Gly  Arg Arg Ser 
    1415                 1420                 1425             


Arg Gln  Gln Glu Leu Met Trp  Pro Ala Asn Pro Ser  Ser Cys Cys 
    1430                 1435                 1440             


Tyr Asn  Ala Pro Tyr Leu Ser  Val Tyr Ser Glu Asn  Ala Val Asp 
    1445                 1450                 1455             


Ile Phe  Asp Val Asn Ser Met  Glu Trp Ile Gln Thr  Leu Pro Leu 
    1460                 1465                 1470             


Lys Lys  Val Arg Pro Leu Asn  Asn Glu Gly Ser Leu  Asn Leu Leu 
    1475                 1480                 1485             


Gly Leu  Glu Thr Ile Arg Leu  Ile Tyr Phe Lys Asn  Lys Met Ala 
    1490                 1495                 1500             


Glu Gly  Asp Glu Leu Val Val  Pro Glu Thr Ser Asp  Asn Ser Arg 
    1505                 1510                 1515             


Lys Gln  Met Val Arg Asn Ile  Asn Asn Lys Arg Arg  Tyr Ser Phe 
    1520                 1525                 1530             


Arg Val  Pro Glu Glu Glu Arg  Met Gln Gln Arg Arg  Glu Met Leu 
    1535                 1540                 1545             


Arg Asp  Pro Glu Met Arg Asn  Lys Leu Ile Ser Asn  Pro Thr Asn 
    1550                 1555                 1560             


Phe Asn  His Ile Ala His Met  Gly Pro Gly Asp Gly  Ile Gln Ile 
    1565                 1570                 1575             


Leu Lys  Asp Leu Pro Met Asn  Pro Arg Pro Gln Glu  Ser Arg Thr 
    1580                 1585                 1590             


Val Phe  Ser Gly Ser Val Ser  Ile Pro Ser Ile Thr  Lys Ser Arg 
    1595                 1600                 1605             


Pro Glu  Pro Gly Arg Ser Met  Ser Ala Ser Ser Gly  Leu Ser Ala 
    1610                 1615                 1620             


Arg Ser  Ser Ala Gln Asn Gly  Ser Ala Leu Lys Arg  Glu Phe Ser 
    1625                 1630                 1635             


Gly Gly  Ser Tyr Ser Ala Lys  Arg Gln Pro Met Pro  Ser Pro Ser 
    1640                 1645                 1650             


Glu Gly  Ser Leu Ser Ser Gly  Gly Met Asp Gln Gly  Ser Asp Ala 
    1655                 1660                 1665             


Pro Ala  Arg Asp Phe Asp Gly  Glu Asp Ser Asp Ser  Pro Arg His 
    1670                 1675                 1680             


Ser Thr  Ala Ser Asn Ser Ser  Asn Leu Ser Ser Pro  Pro Ser Pro 
    1685                 1690                 1695             


Ala Ser  Pro Arg Lys Thr Lys  Ser Leu Ser Leu Glu  Ser Thr Asp 
    1700                 1705                 1710             


Arg Gly  Ser Trp Asp Pro 
    1715                 


<210>  1881
<211>  1711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC42BPB__Homo_sapiens__NP_006026

<400>  1881

Met Ser Ala Lys Val Arg Leu Lys Lys Leu Glu Gln Leu Leu Leu Asp 
1               5                   10                  15      


Gly Pro Trp Arg Asn Glu Ser Ala Leu Ser Val Glu Thr Leu Leu Asp 
            20                  25                  30          


Val Leu Val Cys Leu Tyr Thr Glu Cys Ser His Ser Ala Leu Arg Arg 
        35                  40                  45              


Asp Lys Tyr Val Ala Glu Phe Leu Glu Trp Ala Lys Pro Phe Thr Gln 
    50                  55                  60                  


Leu Val Lys Glu Met Gln Leu His Arg Glu Asp Phe Glu Ile Ile Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Ala Val Val Lys Met Lys 
                85                  90                  95      


Asn Thr Glu Arg Ile Tyr Ala Met Lys Ile Leu Asn Lys Trp Glu Met 
            100                 105                 110         


Leu Lys Arg Ala Glu Thr Ala Cys Phe Arg Glu Glu Arg Asp Val Leu 
        115                 120                 125             


Val Asn Gly Asp Cys Gln Trp Ile Thr Ala Leu His Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Glu Asn His Leu Tyr Leu Val Met Asp Tyr Tyr Val Gly Gly Asp 
145                 150                 155                 160 


Leu Leu Thr Leu Leu Ser Lys Phe Glu Asp Lys Leu Pro Glu Asp Met 
                165                 170                 175     


Ala Arg Phe Tyr Ile Gly Glu Met Val Leu Ala Ile Asp Ser Ile His 
            180                 185                 190         


Gln Leu His Tyr Val His Arg Asp Ile Lys Pro Asp Asn Val Leu Leu 
        195                 200                 205             


Asp Val Asn Gly His Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Lys 
    210                 215                 220                 


Met Asn Asp Asp Gly Thr Val Gln Ser Ser Val Ala Val Gly Thr Pro 
225                 230                 235                 240 


Asp Tyr Ile Ser Pro Glu Ile Leu Gln Ala Met Glu Asp Gly Met Gly 
                245                 250                 255     


Lys Tyr Gly Pro Glu Cys Asp Trp Trp Ser Leu Gly Val Cys Met Tyr 
            260                 265                 270         


Glu Met Leu Tyr Gly Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val Glu 
        275                 280                 285             


Thr Tyr Gly Lys Ile Met Asn His Glu Glu Arg Phe Gln Phe Pro Ser 
    290                 295                 300                 


His Val Thr Asp Val Ser Glu Glu Ala Lys Asp Leu Ile Gln Arg Leu 
305                 310                 315                 320 


Ile Cys Ser Arg Glu Arg Arg Leu Gly Gln Asn Gly Ile Glu Asp Phe 
                325                 330                 335     


Lys Lys His Ala Phe Phe Glu Gly Leu Asn Trp Glu Asn Ile Arg Asn 
            340                 345                 350         


Leu Glu Ala Pro Tyr Ile Pro Asp Val Ser Ser Pro Ser Asp Thr Ser 
        355                 360                 365             


Asn Phe Asp Val Asp Asp Asp Val Leu Arg Asn Thr Glu Ile Leu Pro 
    370                 375                 380                 


Pro Gly Ser His Thr Gly Phe Ser Gly Leu His Leu Pro Phe Ile Gly 
385                 390                 395                 400 


Phe Thr Phe Thr Thr Glu Ser Cys Phe Ser Asp Arg Gly Ser Leu Lys 
                405                 410                 415     


Ser Ile Met Gln Ser Asn Thr Leu Thr Lys Asp Glu Asp Val Gln Arg 
            420                 425                 430         


Asp Leu Glu His Ser Leu Gln Met Glu Ala Tyr Glu Arg Arg Ile Arg 
        435                 440                 445             


Arg Leu Glu Gln Glu Lys Leu Glu Leu Ser Arg Lys Leu Gln Glu Ser 
    450                 455                 460                 


Thr Gln Thr Val Gln Ser Leu His Gly Ser Ser Arg Ala Leu Ser Asn 
465                 470                 475                 480 


Ser Asn Arg Asp Lys Glu Ile Lys Lys Leu Asn Glu Glu Ile Glu Arg 
                485                 490                 495     


Leu Lys Asn Lys Ile Ala Asp Ser Asn Arg Leu Glu Arg Gln Leu Glu 
            500                 505                 510         


Asp Thr Val Ala Leu Arg Gln Glu Arg Glu Asp Ser Thr Gln Arg Leu 
        515                 520                 525             


Arg Gly Leu Glu Lys Gln His Arg Val Val Arg Gln Glu Lys Glu Glu 
    530                 535                 540                 


Leu His Lys Gln Leu Val Glu Ala Ser Glu Arg Leu Lys Ser Gln Ala 
545                 550                 555                 560 


Lys Glu Leu Lys Asp Ala His Gln Gln Arg Lys Leu Ala Leu Gln Glu 
                565                 570                 575     


Phe Ser Glu Leu Asn Glu Arg Met Ala Glu Leu Arg Ala Gln Lys Gln 
            580                 585                 590         


Lys Val Ser Arg Gln Leu Arg Asp Lys Glu Glu Glu Met Glu Val Ala 
        595                 600                 605             


Thr Gln Lys Val Asp Ala Met Arg Gln Glu Met Arg Arg Ala Glu Lys 
    610                 615                 620                 


Leu Arg Lys Glu Leu Glu Ala Gln Leu Asp Asp Ala Val Ala Glu Ala 
625                 630                 635                 640 


Ser Lys Glu Arg Lys Leu Arg Glu His Ser Glu Asn Phe Cys Lys Gln 
                645                 650                 655     


Met Glu Ser Glu Leu Glu Ala Leu Lys Val Lys Gln Gly Gly Arg Gly 
            660                 665                 670         


Ala Gly Ala Thr Leu Glu His Gln Gln Glu Ile Ser Lys Ile Lys Ser 
        675                 680                 685             


Glu Leu Glu Lys Lys Val Leu Phe Tyr Glu Glu Glu Leu Val Arg Arg 
    690                 695                 700                 


Glu Ala Ser His Val Leu Glu Val Lys Asn Val Lys Lys Glu Val His 
705                 710                 715                 720 


Asp Ser Glu Ser His Gln Leu Ala Leu Gln Lys Glu Ile Leu Met Leu 
                725                 730                 735     


Lys Asp Lys Leu Glu Lys Ser Lys Arg Glu Arg His Asn Glu Met Glu 
            740                 745                 750         


Glu Ala Val Gly Thr Ile Lys Asp Lys Tyr Glu Arg Glu Arg Ala Met 
        755                 760                 765             


Leu Phe Asp Glu Asn Lys Lys Leu Thr Ala Glu Asn Glu Lys Leu Cys 
    770                 775                 780                 


Ser Phe Val Asp Lys Leu Thr Ala Gln Asn Arg Gln Leu Glu Asp Glu 
785                 790                 795                 800 


Leu Gln Asp Leu Ala Ala Lys Lys Glu Ser Val Ala His Trp Glu Ala 
                805                 810                 815     


Gln Ile Ala Glu Ile Ile Gln Trp Val Ser Asp Glu Lys Asp Ala Arg 
            820                 825                 830         


Gly Tyr Leu Gln Ala Leu Ala Ser Lys Met Thr Glu Glu Leu Glu Ala 
        835                 840                 845             


Leu Arg Ser Ser Ser Leu Gly Ser Arg Thr Leu Asp Pro Leu Trp Lys 
    850                 855                 860                 


Val Arg Arg Ser Gln Lys Leu Asp Met Ser Ala Arg Leu Glu Leu Gln 
865                 870                 875                 880 


Ser Ala Leu Glu Ala Glu Ile Arg Ala Lys Gln Leu Val Gln Glu Glu 
                885                 890                 895     


Leu Arg Lys Val Lys Asp Ala Asn Leu Thr Leu Glu Ser Lys Leu Lys 
            900                 905                 910         


Asp Ser Glu Ala Lys Asn Arg Glu Leu Leu Glu Glu Met Glu Ile Leu 
        915                 920                 925             


Lys Lys Lys Met Glu Glu Lys Phe Arg Ala Asp Thr Gly Leu Lys Leu 
    930                 935                 940                 


Pro Asp Phe Gln Asp Ser Ile Phe Glu Tyr Phe Asn Thr Ala Pro Leu 
945                 950                 955                 960 


Ala His Asp Leu Thr Phe Arg Thr Ser Ser Ala Ser Glu Gln Glu Thr 
                965                 970                 975     


Gln Ala Pro Lys Pro Glu Ala Ser Pro Ser Met Ser Val Ala Ala Ser 
            980                 985                 990         


Glu Gln Gln Glu Asp Met Ala Arg  Pro Pro Gln Arg Pro  Ser Ala Val 
        995                 1000                 1005             


Pro Leu  Pro Thr Thr Gln Ala  Leu Ala Leu Ala Gly  Pro Lys Pro 
    1010                 1015                 1020             


Lys Ala  His Gln Phe Ser Ile  Lys Ser Phe Ser Ser  Pro Thr Gln 
    1025                 1030                 1035             


Cys Ser  His Cys Thr Ser Leu  Met Val Gly Leu Ile  Arg Gln Gly 
    1040                 1045                 1050             


Tyr Ala  Cys Glu Val Cys Ser  Phe Ala Cys His Val  Ser Cys Lys 
    1055                 1060                 1065             


Asp Gly  Ala Pro Gln Val Cys  Pro Ile Pro Pro Glu  Gln Ser Lys 
    1070                 1075                 1080             


Arg Pro  Leu Gly Val Asp Val  Gln Arg Gly Ile Gly  Thr Ala Tyr 
    1085                 1090                 1095             


Lys Gly  His Val Lys Val Pro  Lys Pro Thr Gly Val  Lys Lys Gly 
    1100                 1105                 1110             


Trp Gln  Arg Ala Tyr Ala Val  Val Cys Asp Cys Lys  Leu Phe Leu 
    1115                 1120                 1125             


Tyr Asp  Leu Pro Glu Gly Lys  Ser Thr Gln Pro Gly  Val Ile Ala 
    1130                 1135                 1140             


Ser Gln  Val Leu Asp Leu Arg  Asp Asp Glu Phe Ser  Val Ser Ser 
    1145                 1150                 1155             


Val Leu  Ala Ser Asp Val Ile  His Ala Thr Arg Arg  Asp Ile Pro 
    1160                 1165                 1170             


Cys Ile  Phe Arg Val Thr Ala  Ser Leu Leu Gly Ala  Pro Ser Lys 
    1175                 1180                 1185             


Thr Ser  Ser Leu Leu Ile Leu  Thr Glu Asn Glu Asn  Glu Lys Arg 
    1190                 1195                 1200             


Lys Trp  Val Gly Ile Leu Glu  Gly Leu Gln Ser Ile  Leu His Lys 
    1205                 1210                 1215             


Asn Arg  Leu Arg Asn Gln Val  Val His Val Pro Leu  Glu Ala Tyr 
    1220                 1225                 1230             


Asp Ser  Ser Leu Pro Leu Ile  Lys Ala Ile Leu Thr  Ala Ala Ile 
    1235                 1240                 1245             


Val Asp  Ala Asp Arg Ile Ala  Val Gly Leu Glu Glu  Gly Leu Tyr 
    1250                 1255                 1260             


Val Ile  Glu Val Thr Arg Asp  Val Ile Val Arg Ala  Ala Asp Cys 
    1265                 1270                 1275             


Lys Lys  Val His Gln Ile Glu  Leu Ala Pro Arg Glu  Lys Ile Val 
    1280                 1285                 1290             


Ile Leu  Leu Cys Gly Arg Asn  His His Val His Leu  Tyr Pro Trp 
    1295                 1300                 1305             


Ser Ser  Leu Asp Gly Ala Glu  Gly Ser Phe Asp Ile  Lys Leu Pro 
    1310                 1315                 1320             


Glu Thr  Lys Gly Cys Gln Leu  Met Ala Thr Ala Thr  Leu Lys Arg 
    1325                 1330                 1335             


Asn Ser  Gly Thr Cys Leu Phe  Val Ala Val Lys Arg  Leu Ile Leu 
    1340                 1345                 1350             


Cys Tyr  Glu Ile Gln Arg Thr  Lys Pro Phe His Arg  Lys Phe Asn 
    1355                 1360                 1365             


Glu Ile  Val Ala Pro Gly Ser  Val Gln Cys Leu Ala  Val Leu Arg 
    1370                 1375                 1380             


Asp Arg  Leu Cys Val Gly Tyr  Pro Ser Gly Phe Cys  Leu Leu Ser 
    1385                 1390                 1395             


Ile Gln  Gly Asp Gly Gln Pro  Leu Asn Leu Val Asn  Pro Asn Asp 
    1400                 1405                 1410             


Pro Ser  Leu Ala Phe Leu Ser  Gln Gln Ser Phe Asp  Ala Leu Cys 
    1415                 1420                 1425             


Ala Val  Glu Leu Glu Ser Glu  Glu Tyr Leu Leu Cys  Phe Ser His 
    1430                 1435                 1440             


Met Gly  Leu Tyr Val Asp Pro  Gln Gly Arg Arg Ala  Arg Ala Gln 
    1445                 1450                 1455             


Glu Leu  Met Trp Pro Ala Ala  Pro Val Ala Cys Ser  Cys Ser Pro 
    1460                 1465                 1470             


Thr His  Val Thr Val Tyr Ser  Glu Tyr Gly Val Asp  Val Phe Asp 
    1475                 1480                 1485             


Val Arg  Thr Met Glu Trp Val  Gln Thr Ile Gly Leu  Arg Arg Ile 
    1490                 1495                 1500             


Arg Pro  Leu Asn Ser Glu Gly  Thr Leu Asn Leu Leu  Asn Cys Glu 
    1505                 1510                 1515             


Pro Pro  Arg Leu Ile Tyr Phe  Lys Ser Lys Phe Ser  Gly Ala Val 
    1520                 1525                 1530             


Leu Asn  Val Pro Asp Thr Ser  Asp Asn Ser Lys Lys  Gln Met Leu 
    1535                 1540                 1545             


Arg Thr  Arg Ser Lys Arg Arg  Phe Val Phe Lys Val  Pro Glu Glu 
    1550                 1555                 1560             


Glu Arg  Leu Gln Gln Arg Arg  Glu Met Leu Arg Asp  Pro Glu Leu 
    1565                 1570                 1575             


Arg Ser  Lys Met Ile Ser Asn  Pro Thr Asn Phe Asn  His Val Ala 
    1580                 1585                 1590             


His Met  Gly Pro Gly Asp Gly  Met Gln Val Leu Met  Asp Leu Pro 
    1595                 1600                 1605             


Leu Ser  Ala Val Pro Pro Ser  Gln Glu Glu Arg Pro  Gly Pro Ala 
    1610                 1615                 1620             


Pro Thr  Asn Leu Ala Arg Gln  Pro Pro Ser Arg Asn  Lys Pro Tyr 
    1625                 1630                 1635             


Ile Ser  Trp Pro Ser Ser Gly  Gly Ser Glu Pro Ser  Val Thr Val 
    1640                 1645                 1650             


Pro Leu  Arg Ser Met Ser Asp  Pro Asp Gln Asp Phe  Asp Lys Glu 
    1655                 1660                 1665             


Pro Asp  Ser Asp Ser Thr Lys  His Ser Thr Pro Ser  Asn Ser Ser 
    1670                 1675                 1680             


Asn Pro  Ser Gly Pro Pro Ser  Pro Asn Ser Pro His  Arg Ser Gln 
    1685                 1690                 1695             


Leu Pro  Leu Glu Gly Leu Glu  Gln Pro Ala Cys Asp  Thr 
    1700                 1705                 1710     


<210>  1882
<211>  1551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC42BPG__Homo_sapiens__NP_059995

<400>  1882

Met Glu Arg Arg Leu Arg Ala Leu Glu Gln Leu Ala Arg Gly Glu Ala 
1               5                   10                  15      


Gly Gly Cys Pro Gly Leu Asp Gly Leu Leu Asp Leu Leu Leu Ala Leu 
            20                  25                  30          


His His Glu Leu Ser Ser Gly Pro Leu Arg Arg Glu Arg Ser Val Ala 
        35                  40                  45              


Gln Phe Leu Ser Trp Ala Ser Pro Phe Val Ser Lys Val Lys Glu Leu 
    50                  55                  60                  


Arg Leu Gln Arg Asp Asp Phe Glu Ile Leu Lys Val Ile Gly Arg Gly 
65                  70                  75                  80  


Ala Phe Gly Glu Val Thr Val Val Arg Gln Arg Asp Thr Gly Gln Ile 
                85                  90                  95      


Phe Ala Met Lys Met Leu His Lys Trp Glu Met Leu Lys Arg Ala Glu 
            100                 105                 110         


Thr Ala Cys Phe Arg Glu Glu Arg Asp Val Leu Val Lys Gly Asp Ser 
        115                 120                 125             


Arg Trp Val Thr Thr Leu His Tyr Ala Phe Gln Asp Glu Glu Tyr Leu 
    130                 135                 140                 


Tyr Leu Val Met Asp Tyr Tyr Ala Gly Gly Asp Leu Leu Thr Leu Leu 
145                 150                 155                 160 


Ser Arg Phe Glu Asp Arg Leu Pro Pro Glu Leu Ala Gln Phe Tyr Leu 
                165                 170                 175     


Ala Glu Met Val Leu Ala Ile His Ser Leu His Gln Leu Gly Tyr Val 
            180                 185                 190         


His Arg Asp Val Lys Pro Asp Asn Val Leu Leu Asp Val Asn Gly His 
        195                 200                 205             


Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Arg Leu Asn Thr Asn Gly 
    210                 215                 220                 


Met Val Asp Ser Ser Val Ala Val Gly Thr Pro Asp Tyr Ile Ser Pro 
225                 230                 235                 240 


Glu Ile Leu Gln Ala Met Glu Glu Gly Lys Gly His Tyr Gly Pro Gln 
                245                 250                 255     


Cys Asp Trp Trp Ser Leu Gly Val Cys Ala Tyr Glu Leu Leu Phe Gly 
            260                 265                 270         


Glu Thr Pro Phe Tyr Ala Glu Ser Leu Val Glu Thr Tyr Gly Lys Ile 
        275                 280                 285             


Met Asn His Glu Asp His Leu Gln Phe Pro Pro Asp Val Pro Asp Val 
    290                 295                 300                 


Pro Ala Ser Ala Gln Asp Leu Ile Arg Gln Leu Leu Cys Arg Gln Glu 
305                 310                 315                 320 


Glu Arg Leu Gly Arg Gly Gly Leu Asp Asp Phe Arg Asn His Pro Phe 
                325                 330                 335     


Phe Glu Gly Val Asp Trp Glu Arg Leu Ala Ser Ser Thr Ala Pro Tyr 
            340                 345                 350         


Ile Pro Glu Leu Arg Gly Pro Met Asp Thr Ser Asn Phe Asp Val Asp 
        355                 360                 365             


Asp Asp Thr Leu Asn His Pro Gly Thr Leu Pro Pro Pro Ser His Gly 
    370                 375                 380                 


Ala Phe Ser Gly His His Leu Pro Phe Val Gly Phe Thr Tyr Thr Ser 
385                 390                 395                 400 


Gly Ser His Ser Pro Glu Ser Ser Ser Glu Ala Trp Ala Ala Leu Glu 
                405                 410                 415     


Arg Lys Leu Gln Cys Leu Glu Gln Glu Lys Val Glu Leu Ser Arg Lys 
            420                 425                 430         


His Gln Glu Ala Leu His Ala Pro Thr Asp His Arg Glu Leu Glu Gln 
        435                 440                 445             


Leu Arg Lys Glu Val Gln Thr Leu Arg Asp Arg Leu Pro Glu Met Leu 
    450                 455                 460                 


Arg Asp Lys Ala Ser Leu Ser Gln Thr Asp Gly Pro Pro Ala Gly Ser 
465                 470                 475                 480 


Pro Gly Gln Asp Ser Asp Leu Arg Gln Glu Leu Asp Arg Leu His Arg 
                485                 490                 495     


Glu Leu Ala Glu Gly Arg Ala Gly Leu Gln Ala Gln Glu Gln Glu Leu 
            500                 505                 510         


Cys Arg Ala Gln Gly Gln Gln Glu Glu Leu Leu Gln Arg Leu Gln Glu 
        515                 520                 525             


Ala Gln Glu Arg Glu Ala Ala Thr Ala Ser Gln Thr Arg Ala Leu Ser 
    530                 535                 540                 


Ser Gln Leu Glu Glu Ala Arg Ala Ala Gln Arg Glu Leu Glu Ala Gln 
545                 550                 555                 560 


Val Ser Ser Leu Ser Arg Gln Val Thr Gln Leu Gln Gly Gln Trp Glu 
                565                 570                 575     


Gln Arg Leu Glu Glu Ser Ser Gln Ala Lys Thr Ile His Thr Ala Ser 
            580                 585                 590         


Glu Thr Asn Gly Met Gly Pro Pro Glu Gly Gly Pro Gln Glu Ala Gln 
        595                 600                 605             


Leu Arg Lys Glu Val Ala Ala Leu Arg Glu Gln Leu Glu Gln Ala His 
    610                 615                 620                 


Ser His Arg Pro Ser Gly Lys Glu Glu Ala Leu Cys Gln Leu Gln Glu 
625                 630                 635                 640 


Glu Asn Arg Arg Leu Ser Arg Glu Gln Glu Arg Leu Glu Ala Glu Leu 
                645                 650                 655     


Ala Gln Glu Gln Glu Ser Lys Gln Arg Leu Glu Gly Glu Arg Arg Glu 
            660                 665                 670         


Thr Glu Ser Asn Trp Glu Ala Gln Leu Ala Asp Ile Leu Ser Trp Val 
        675                 680                 685             


Asn Asp Glu Lys Val Ser Arg Gly Tyr Leu Gln Ala Leu Ala Thr Lys 
    690                 695                 700                 


Met Ala Glu Glu Leu Glu Ser Leu Arg Asn Val Gly Thr Gln Thr Leu 
705                 710                 715                 720 


Pro Ala Arg Pro Leu Asp His Gln Trp Lys Ala Arg Arg Leu Gln Lys 
                725                 730                 735     


Met Glu Ala Ser Ala Arg Leu Glu Leu Gln Ser Ala Leu Glu Ala Glu 
            740                 745                 750         


Ile Arg Ala Lys Gln Gly Leu Gln Glu Arg Leu Thr Gln Val Gln Glu 
        755                 760                 765             


Ala Gln Leu Gln Ala Glu Arg Arg Leu Gln Glu Ala Glu Lys Gln Ser 
    770                 775                 780                 


Gln Ala Leu Gln Gln Glu Leu Ala Met Leu Arg Glu Glu Leu Arg Ala 
785                 790                 795                 800 


Arg Gly Pro Val Asp Thr Lys Pro Ser Asn Ser Leu Ile Pro Phe Leu 
                805                 810                 815     


Ser Phe Arg Ser Ser Glu Lys Asp Ser Ala Lys Asp Pro Gly Ile Ser 
            820                 825                 830         


Gly Glu Ala Thr Arg His Gly Gly Glu Pro Asp Leu Arg Pro Glu Gly 
        835                 840                 845             


Arg Arg Ser Leu Arg Met Gly Ala Val Phe Pro Arg Ala Pro Thr Ala 
    850                 855                 860                 


Asn Thr Ala Ser Thr Glu Gly Leu Pro Ala Lys Pro Gly Ser His Thr 
865                 870                 875                 880 


Leu Arg Pro Arg Ser Phe Pro Ser Pro Thr Lys Cys Leu Arg Cys Thr 
                885                 890                 895     


Ser Leu Met Leu Gly Leu Gly Arg Gln Gly Leu Gly Cys Asp Ala Cys 
            900                 905                 910         


Gly Tyr Phe Cys His Thr Thr Cys Ala Pro Gln Ala Pro Pro Cys Pro 
        915                 920                 925             


Val Pro Pro Asp Leu Leu Arg Thr Ala Leu Gly Val His Pro Glu Thr 
    930                 935                 940                 


Gly Thr Gly Thr Ala Tyr Glu Gly Phe Leu Ser Val Pro Arg Pro Ser 
945                 950                 955                 960 


Gly Val Arg Arg Gly Trp Gln Arg Val Phe Ala Ala Leu Ser Asp Ser 
                965                 970                 975     


Arg Leu Leu Leu Phe Asp Ala Pro Asp Leu Arg Leu Ser Pro Pro Ser 
            980                 985                 990         


Gly Ala Leu Leu Gln Val Leu Asp  Leu Arg Asp Pro Gln  Phe Ser Ala 
        995                 1000                 1005             


Thr Pro  Val Leu Ala Ser Asp  Val Ile His Ala Gln  Ser Arg Asp 
    1010                 1015                 1020             


Leu Pro  Arg Ile Phe Arg Val  Thr Thr Ser Gln Leu  Ala Val Pro 
    1025                 1030                 1035             


Pro Thr  Thr Cys Thr Val Leu  Leu Leu Ala Glu Ser  Glu Gly Glu 
    1040                 1045                 1050             


Arg Glu  Arg Trp Leu Gln Val  Leu Gly Glu Leu Gln  Arg Leu Leu 
    1055                 1060                 1065             


Leu Asp  Ala Arg Pro Arg Pro  Arg Pro Val Tyr Thr  Leu Lys Glu 
    1070                 1075                 1080             


Ala Tyr  Asp Asn Gly Leu Pro  Leu Leu Pro His Thr  Leu Cys Ala 
    1085                 1090                 1095             


Ala Ile  Leu Asp Gln Asp Arg  Leu Ala Leu Gly Thr  Glu Glu Gly 
    1100                 1105                 1110             


Leu Phe  Val Ile His Leu Arg  Ser Asn Asp Ile Phe  Gln Val Gly 
    1115                 1120                 1125             


Glu Cys  Arg Arg Val Gln Gln  Leu Thr Leu Ser Pro  Ser Ala Gly 
    1130                 1135                 1140             


Leu Leu  Val Val Leu Cys Gly  Arg Gly Pro Ser Val  Arg Leu Phe 
    1145                 1150                 1155             


Ala Leu  Ala Glu Leu Glu Asn  Ile Glu Val Ala Gly  Ala Lys Ile 
    1160                 1165                 1170             


Pro Glu  Ser Arg Gly Cys Gln  Val Leu Ala Ala Gly  Ser Ile Leu 
    1175                 1180                 1185             


Gln Ala  Arg Thr Pro Val Leu  Cys Val Ala Val Lys  Arg Gln Val 
    1190                 1195                 1200             


Leu Cys  Tyr Gln Leu Gly Pro  Gly Pro Gly Pro Trp  Gln Arg Arg 
    1205                 1210                 1215             


Ile Arg  Glu Leu Gln Ala Pro  Ala Thr Val Gln Ser  Leu Gly Leu 
    1220                 1225                 1230             


Leu Gly  Asp Arg Leu Cys Val  Gly Ala Ala Gly Gly  Phe Ala Leu 
    1235                 1240                 1245             


Tyr Pro  Leu Leu Asn Glu Ala  Ala Pro Leu Ala Leu  Gly Ala Gly 
    1250                 1255                 1260             


Leu Val  Pro Glu Glu Leu Pro  Pro Ser Arg Gly Gly  Leu Gly Glu 
    1265                 1270                 1275             


Ala Leu  Gly Ala Val Glu Leu  Ser Leu Ser Glu Phe  Leu Leu Leu 
    1280                 1285                 1290             


Phe Thr  Thr Ala Gly Ile Tyr  Val Asp Gly Ala Gly  Arg Lys Ser 
    1295                 1300                 1305             


Arg Gly  His Glu Leu Leu Trp  Pro Ala Ala Pro Met  Gly Trp Gly 
    1310                 1315                 1320             


Tyr Ala  Ala Pro Tyr Leu Thr  Val Phe Ser Glu Asn  Ser Ile Asp 
    1325                 1330                 1335             


Val Phe  Asp Val Arg Arg Ala  Glu Trp Val Gln Thr  Val Pro Leu 
    1340                 1345                 1350             


Lys Lys  Val Arg Pro Leu Asn  Pro Glu Gly Ser Leu  Phe Leu Tyr 
    1355                 1360                 1365             


Gly Thr  Glu Lys Val Arg Leu  Thr Tyr Leu Arg Asn  Gln Leu Ala 
    1370                 1375                 1380             


Glu Lys  Asp Glu Phe Asp Ile  Pro Asp Leu Thr Asp  Asn Ser Arg 
    1385                 1390                 1395             


Arg Gln  Leu Phe Arg Thr Lys  Ser Lys Arg Arg Phe  Phe Phe Arg 
    1400                 1405                 1410             


Val Ser  Glu Glu Gln Gln Lys  Gln Gln Arg Arg Glu  Met Leu Lys 
    1415                 1420                 1425             


Asp Pro  Phe Val Arg Ser Lys  Leu Ile Ser Pro Pro  Thr Asn Phe 
    1430                 1435                 1440             


Asn His  Leu Val His Val Gly  Pro Ala Asn Gly Arg  Pro Gly Ala 
    1445                 1450                 1455             


Arg Asp  Lys Ser Pro Ala Pro  Glu Glu Lys Gly Arg  Val Ala Arg 
    1460                 1465                 1470             


Gly Ser  Gly Pro Gln Arg Pro  His Ser Phe Ser Glu  Ala Leu Arg 
    1475                 1480                 1485             


Arg Pro  Ala Ser Met Gly Ser  Glu Gly Leu Gly Gly  Asp Ala Asp 
    1490                 1495                 1500             


Pro Met  Lys Arg Lys Pro Trp  Thr Ser Leu Ser Ser  Glu Ser Val 
    1505                 1510                 1515             


Ser Cys  Pro Gln Gly Ser Leu  Ser Pro Ala Thr Ser  Leu Met Gln 
    1520                 1525                 1530             


Val Ser  Glu Arg Pro Arg Ser  Leu Pro Leu Ser Pro  Glu Leu Glu 
    1535                 1540                 1545             


Ser Ser  Pro 
    1550     


<210>  1883
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC42EP1__Homo_sapiens__NP_689449

<400>  1883

Met Pro Gly Pro Gln Gly Gly Arg Gly Ala Ala Thr Met Ser Leu Gly 
1               5                   10                  15      


Lys Leu Ser Pro Val Gly Trp Val Ser Ser Ser Gln Gly Lys Arg Arg 
            20                  25                  30          


Leu Thr Ala Asp Met Ile Ser His Pro Leu Gly Asp Phe Arg His Thr 
        35                  40                  45              


Met His Val Gly Arg Gly Gly Asp Val Phe Gly Asp Thr Ser Phe Leu 
    50                  55                  60                  


Ser Asn His Gly Gly Ser Ser Gly Ser Thr His Arg Ser Pro Arg Ser 
65                  70                  75                  80  


Phe Leu Ala Lys Lys Leu Gln Leu Val Arg Arg Val Gly Ala Pro Pro 
                85                  90                  95      


Arg Arg Met Ala Ser Pro Pro Ala Pro Ser Pro Ala Pro Pro Ala Ile 
            100                 105                 110         


Ser Pro Ile Ile Lys Asn Ala Ile Ser Leu Pro Gln Leu Asn Gln Ala 
        115                 120                 125             


Ala Tyr Asp Ser Leu Val Val Gly Lys Leu Ser Phe Asp Ser Ser Pro 
    130                 135                 140                 


Thr Ser Ser Thr Asp Gly His Ser Ser Tyr Gly Leu Asp Ser Gly Phe 
145                 150                 155                 160 


Cys Thr Ile Ser Arg Leu Pro Arg Ser Glu Lys Pro His Asp Arg Asp 
                165                 170                 175     


Arg Asp Gly Ser Phe Pro Ser Glu Pro Gly Leu Arg Arg Ser Asp Ser 
            180                 185                 190         


Leu Leu Ser Phe Arg Leu Asp Leu Asp Leu Gly Pro Ser Leu Leu Ser 
        195                 200                 205             


Glu Leu Leu Gly Val Met Ser Leu Pro Glu Ala Pro Ala Ala Glu Thr 
    210                 215                 220                 


Pro Ala Pro Ala Ala Asn Pro Pro Ala Pro Thr Ala Asn Pro Thr Gly 
225                 230                 235                 240 


Pro Ala Ala Asn Pro Pro Ala Thr Thr Ala Asn Pro Pro Ala Pro Ala 
                245                 250                 255     


Ala Asn Pro Ser Ala Pro Ala Ala Thr Pro Thr Gly Pro Ala Ala Asn 
            260                 265                 270         


Pro Pro Ala Pro Ala Ala Ser Ser Thr Pro His Gly His Cys Pro Asn 
        275                 280                 285             


Gly Val Thr Ala Gly Leu Gly Pro Val Ala Glu Val Lys Ser Ser Pro 
    290                 295                 300                 


Val Gly Gly Gly Pro Arg Gly Pro Ala Gly Pro Ala Leu Gly Arg His 
305                 310                 315                 320 


Trp Gly Ala Gly Trp Asp Gly Gly His His Tyr Pro Glu Met Asp Ala 
                325                 330                 335     


Arg Gln Glu Arg Val Glu Val Leu Pro Gln Ala Arg Ala Ser Trp Glu 
            340                 345                 350         


Ser Leu Asp Glu Glu Trp Arg Ala Pro Gln Ala Gly Ser Arg Thr Pro 
        355                 360                 365             


Val Pro Ser Thr Val Gln Ala Asn Thr Phe Glu Phe Ala Asp Ala Glu 
    370                 375                 380                 


Glu Asp Asp Glu Val Lys Val 
385                 390     


<210>  1884
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC42EP3__Homo_sapiens__NP_006440

<400>  1884

Met Pro Ala Lys Thr Pro Ile Tyr Leu Lys Ala Ala Asn Asn Lys Lys 
1               5                   10                  15      


Gly Lys Lys Phe Lys Leu Arg Asp Ile Leu Ser Pro Asp Met Ile Ser 
            20                  25                  30          


Pro Pro Leu Gly Asp Phe Arg His Thr Ile His Ile Gly Lys Glu Gly 
        35                  40                  45              


Gln His Asp Val Phe Gly Asp Ile Ser Phe Leu Gln Gly Asn Tyr Glu 
    50                  55                  60                  


Leu Leu Pro Gly Asn Gln Glu Lys Ala His Leu Gly Gln Phe Pro Gly 
65                  70                  75                  80  


His Asn Glu Phe Phe Arg Ala Asn Ser Thr Ser Asp Ser Val Phe Thr 
                85                  90                  95      


Glu Thr Pro Ser Pro Val Leu Lys Asn Ala Ile Ser Leu Pro Thr Ile 
            100                 105                 110         


Gly Gly Ser Gln Ala Leu Met Leu Pro Leu Leu Ser Pro Val Thr Phe 
        115                 120                 125             


Asn Ser Lys Gln Glu Ser Phe Gly Pro Ala Lys Leu Pro Arg Leu Ser 
    130                 135                 140                 


Cys Glu Pro Val Met Glu Glu Lys Ala Gln Glu Lys Ser Ser Leu Leu 
145                 150                 155                 160 


Glu Asn Gly Thr Val His Gln Gly Asp Thr Ser Trp Gly Ser Ser Gly 
                165                 170                 175     


Ser Ala Ser Gln Ser Ser Gln Gly Arg Asp Ser His Ser Ser Ser Leu 
            180                 185                 190         


Ser Glu Gln Tyr Pro Asp Trp Pro Ala Glu Asp Met Phe Asp His Pro 
        195                 200                 205             


Thr Pro Cys Glu Leu Ile Lys Gly Lys Thr Lys Ser Glu Glu Ser Leu 
    210                 215                 220                 


Ser Asp Leu Thr Gly Ser Leu Leu Ser Leu Gln Leu Asp Leu Gly Pro 
225                 230                 235                 240 


Ser Leu Leu Asp Glu Val Leu Asn Val Met Asp Lys Asn Lys 
                245                 250                 


<210>  1885
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC42SE2__Homo_sapiens__NP_001033791

<400>  1885

Met Ser Glu Phe Trp Leu Cys Phe Asn Cys Cys Ile Ala Glu Gln Pro 
1               5                   10                  15      


Gln Pro Lys Arg Arg Arg Arg Ile Asp Arg Ser Met Ile Gly Glu Pro 
            20                  25                  30          


Thr Asn Phe Val His Thr Ala His Val Gly Ser Gly Asp Leu Phe Ser 
        35                  40                  45              


Gly Met Asn Ser Val Ser Ser Ile Gln Asn Gln Met Gln Ser Lys Gly 
    50                  55                  60                  


Gly Tyr Gly Gly Gly Met Pro Ala Asn Val Gln Met Gln Leu Val Asp 
65                  70                  75                  80  


Thr Lys Ala Gly 
                


<210>  1886
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC45__Homo_sapiens__XP_005261342

<400>  1886

Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Ser Gly Ser Gly Ser Glu Pro Val Ala Ala Ala Leu 
            180                 185                 190         


Glu Lys Ser Ser Arg Leu Phe Ala Gly Pro Met Ser Asp Arg Thr Ala 
        195                 200                 205             


Pro Arg Ser Pro Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
    210                 215                 220                 


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
225                 230                 235                 240 


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
                245                 250                 255     


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
            260                 265                 270         


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
        275                 280                 285             


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
    290                 295                 300                 


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
305                 310                 315                 320 


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
                325                 330                 335     


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
            340                 345                 350         


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
        355                 360                 365             


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
    370                 375                 380                 


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
385                 390                 395                 400 


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
                405                 410                 415     


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
            420                 425                 430         


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
        435                 440                 445             


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
    450                 455                 460                 


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
465                 470                 475                 480 


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
                485                 490                 495     


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
            500                 505                 510         


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
        515                 520                 525             


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
    530                 535                 540                 


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
545                 550                 555                 560 


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
                565                 570                 575     


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
            580                 585                 590         


Leu Ile Ser Leu Leu Ser 
        595             


<210>  1887
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC5L__Homo_sapiens__NP_001244

<400>  1887

Met Pro Arg Ile Met Ile Lys Gly Gly Val Trp Arg Asn Thr Glu Asp 
1               5                   10                  15      


Glu Ile Leu Lys Ala Ala Val Met Lys Tyr Gly Lys Asn Gln Trp Ser 
            20                  25                  30          


Arg Ile Ala Ser Leu Leu His Arg Lys Ser Ala Lys Gln Cys Lys Ala 
        35                  40                  45              


Arg Trp Tyr Glu Trp Leu Asp Pro Ser Ile Lys Lys Thr Glu Trp Ser 
    50                  55                  60                  


Arg Glu Glu Glu Glu Lys Leu Leu His Leu Ala Lys Leu Met Pro Thr 
65                  70                  75                  80  


Gln Trp Arg Thr Ile Ala Pro Ile Ile Gly Arg Thr Ala Ala Gln Cys 
                85                  90                  95      


Leu Glu His Tyr Glu Phe Leu Leu Asp Lys Ala Ala Gln Arg Asp Asn 
            100                 105                 110         


Glu Glu Glu Thr Thr Asp Asp Pro Arg Lys Leu Lys Pro Gly Glu Ile 
        115                 120                 125             


Asp Pro Asn Pro Glu Thr Lys Pro Ala Arg Pro Asp Pro Ile Asp Met 
    130                 135                 140                 


Asp Glu Asp Glu Leu Glu Met Leu Ser Glu Ala Arg Ala Arg Leu Ala 
145                 150                 155                 160 


Asn Thr Gln Gly Lys Lys Ala Lys Arg Lys Ala Arg Glu Lys Gln Leu 
                165                 170                 175     


Glu Glu Ala Arg Arg Leu Ala Ala Leu Gln Lys Arg Arg Glu Leu Arg 
            180                 185                 190         


Ala Ala Gly Ile Glu Ile Gln Lys Lys Arg Lys Arg Lys Arg Gly Val 
        195                 200                 205             


Asp Tyr Asn Ala Glu Ile Pro Phe Glu Lys Lys Pro Ala Leu Gly Phe 
    210                 215                 220                 


Tyr Asp Thr Ser Glu Glu Asn Tyr Gln Ala Leu Asp Ala Asp Phe Arg 
225                 230                 235                 240 


Lys Leu Arg Gln Gln Asp Leu Asp Gly Glu Leu Arg Ser Glu Lys Glu 
                245                 250                 255     


Gly Arg Asp Arg Lys Lys Asp Lys Gln His Leu Lys Arg Lys Lys Glu 
            260                 265                 270         


Ser Asp Leu Pro Ser Ala Ile Leu Gln Thr Ser Gly Val Ser Glu Phe 
        275                 280                 285             


Thr Lys Lys Arg Ser Lys Leu Val Leu Pro Ala Pro Gln Ile Ser Asp 
    290                 295                 300                 


Ala Glu Leu Gln Glu Val Val Lys Val Gly Gln Ala Ser Glu Ile Ala 
305                 310                 315                 320 


Arg Gln Thr Ala Glu Glu Ser Gly Ile Thr Asn Ser Ala Ser Ser Thr 
                325                 330                 335     


Leu Leu Ser Glu Tyr Asn Val Thr Asn Asn Ser Val Ala Leu Arg Thr 
            340                 345                 350         


Pro Arg Thr Pro Ala Ser Gln Asp Arg Ile Leu Gln Glu Ala Gln Asn 
        355                 360                 365             


Leu Met Ala Leu Thr Asn Val Asp Thr Pro Leu Lys Gly Gly Leu Asn 
    370                 375                 380                 


Thr Pro Leu His Glu Ser Asp Phe Ser Gly Val Thr Pro Gln Arg Gln 
385                 390                 395                 400 


Val Val Gln Thr Pro Asn Thr Val Leu Ser Thr Pro Phe Arg Thr Pro 
                405                 410                 415     


Ser Asn Gly Ala Glu Gly Leu Thr Pro Arg Ser Gly Thr Thr Pro Lys 
            420                 425                 430         


Pro Val Ile Asn Ser Thr Pro Gly Arg Thr Pro Leu Arg Asp Lys Leu 
        435                 440                 445             


Asn Ile Asn Pro Glu Asp Gly Met Ala Asp Tyr Ser Asp Pro Ser Tyr 
    450                 455                 460                 


Val Lys Gln Met Glu Arg Glu Ser Arg Glu His Leu Arg Leu Gly Leu 
465                 470                 475                 480 


Leu Gly Leu Pro Ala Pro Lys Asn Asp Phe Glu Ile Val Leu Pro Glu 
                485                 490                 495     


Asn Ala Glu Lys Glu Leu Glu Glu Arg Glu Ile Asp Asp Thr Tyr Ile 
            500                 505                 510         


Glu Asp Ala Ala Asp Val Asp Ala Arg Lys Gln Ala Ile Arg Asp Ala 
        515                 520                 525             


Glu Arg Val Lys Glu Met Lys Arg Met His Lys Ala Val Gln Lys Asp 
    530                 535                 540                 


Leu Pro Arg Pro Ser Glu Val Asn Glu Thr Ile Leu Arg Pro Leu Asn 
545                 550                 555                 560 


Val Glu Pro Pro Leu Thr Asp Leu Gln Lys Ser Glu Glu Leu Ile Lys 
                565                 570                 575     


Lys Glu Met Ile Thr Met Leu His Tyr Asp Leu Leu His His Pro Tyr 
            580                 585                 590         


Glu Pro Ser Gly Asn Lys Lys Gly Lys Thr Val Gly Phe Gly Thr Asn 
        595                 600                 605             


Asn Ser Glu His Ile Thr Tyr Leu Glu His Asn Pro Tyr Glu Lys Phe 
    610                 615                 620                 


Ser Lys Glu Glu Leu Lys Lys Ala Gln Asp Val Leu Val Gln Glu Met 
625                 630                 635                 640 


Glu Val Val Lys Gln Gly Met Ser His Gly Glu Leu Ser Ser Glu Ala 
                645                 650                 655     


Tyr Asn Gln Val Trp Glu Glu Cys Tyr Ser Gln Val Leu Tyr Leu Pro 
            660                 665                 670         


Gly Gln Ser Arg Tyr Thr Arg Ala Asn Leu Ala Ser Lys Lys Asp Arg 
        675                 680                 685             


Ile Glu Ser Leu Glu Lys Arg Leu Glu Ile Asn Arg Gly His Met Thr 
    690                 695                 700                 


Thr Glu Ala Lys Arg Ala Ala Lys Met Glu Lys Lys Met Lys Ile Leu 
705                 710                 715                 720 


Leu Gly Gly Tyr Gln Ser Arg Ala Met Gly Leu Met Lys Gln Leu Asn 
                725                 730                 735     


Asp Leu Trp Asp Gln Ile Glu Gln Ala His Leu Glu Leu Arg Thr Phe 
            740                 745                 750         


Glu Glu Leu Lys Lys His Glu Asp Ser Ala Ile Pro Arg Arg Leu Glu 
        755                 760                 765             


Cys Leu Lys Glu Asp Val Gln Arg Gln Gln Glu Arg Glu Lys Glu Leu 
    770                 775                 780                 


Gln His Arg Tyr Ala Asp Leu Leu Leu Glu Lys Glu Thr Leu Lys Ser 
785                 790                 795                 800 


Lys Phe 
        


<210>  1888
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC6__Homo_sapiens__NP_001245

<400>  1888

Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys 
1               5                   10                  15      


Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala 
            20                  25                  30          


Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val 
        35                  40                  45              


Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu 
    50                  55                  60                  


Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys 
65                  70                  75                  80  


Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu 
                85                  90                  95      


Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu 
            100                 105                 110         


Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln 
        115                 120                 125             


Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser 
    130                 135                 140                 


Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala 
145                 150                 155                 160 


Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu 
                165                 170                 175     


Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly 
            180                 185                 190         


Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys 
        195                 200                 205             


Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys 
    210                 215                 220                 


Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln 
225                 230                 235                 240 


Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser 
                245                 250                 255     


Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr 
            260                 265                 270         


Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln 
        275                 280                 285             


Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro 
    290                 295                 300                 


Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu 
305                 310                 315                 320 


Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys 
                325                 330                 335     


Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val 
            340                 345                 350         


Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu 
        355                 360                 365             


Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser 
    370                 375                 380                 


Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile 
385                 390                 395                 400 


Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu 
                405                 410                 415     


Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile 
            420                 425                 430         


His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu 
        435                 440                 445             


Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu 
    450                 455                 460                 


Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val 
465                 470                 475                 480 


Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln 
                485                 490                 495     


Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu 
            500                 505                 510         


Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg 
        515                 520                 525             


Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala 
    530                 535                 540                 


Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro 
545                 550                 555                 560 


<210>  1889
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC73__Homo_sapiens__NP_078805

<400>  1889

Met Ala Asp Val Leu Ser Val Leu Arg Gln Tyr Asn Ile Gln Lys Lys 
1               5                   10                  15      


Glu Ile Val Val Lys Gly Asp Glu Val Ile Phe Gly Glu Phe Ser Trp 
            20                  25                  30          


Pro Lys Asn Val Lys Thr Asn Tyr Val Val Trp Gly Thr Gly Lys Glu 
        35                  40                  45              


Gly Gln Pro Arg Glu Tyr Tyr Thr Leu Asp Ser Ile Leu Phe Leu Leu 
    50                  55                  60                  


Asn Asn Val His Leu Ser His Pro Val Tyr Val Arg Arg Ala Ala Thr 
65                  70                  75                  80  


Glu Asn Ile Pro Val Val Arg Arg Pro Asp Arg Lys Asp Leu Leu Gly 
                85                  90                  95      


Tyr Leu Asn Gly Glu Ala Ser Thr Ser Ala Ser Ile Asp Arg Ser Ala 
            100                 105                 110         


Pro Leu Glu Ile Gly Leu Gln Arg Ser Thr Gln Val Lys Arg Ala Ala 
        115                 120                 125             


Asp Glu Val Leu Ala Glu Ala Lys Lys Pro Arg Ile Glu Asp Glu Glu 
    130                 135                 140                 


Cys Val Arg Leu Asp Lys Glu Arg Leu Ala Ala Arg Leu Glu Gly His 
145                 150                 155                 160 


Lys Glu Gly Ile Val Gln Thr Glu Gln Ile Arg Ser Leu Ser Glu Ala 
                165                 170                 175     


Met Ser Val Glu Lys Ile Ala Ala Ile Lys Ala Lys Ile Met Ala Lys 
            180                 185                 190         


Lys Arg Ser Thr Ile Lys Thr Asp Leu Asp Asp Asp Ile Thr Ala Leu 
        195                 200                 205             


Lys Gln Arg Ser Phe Val Asp Ala Glu Val Asp Val Thr Arg Asp Ile 
    210                 215                 220                 


Val Ser Arg Glu Arg Val Trp Arg Thr Arg Thr Thr Ile Leu Gln Ser 
225                 230                 235                 240 


Thr Gly Lys Asn Phe Ser Lys Asn Ile Phe Ala Ile Leu Gln Ser Val 
                245                 250                 255     


Lys Ala Arg Glu Glu Gly Arg Ala Pro Glu Gln Arg Pro Ala Pro Asn 
            260                 265                 270         


Ala Ala Pro Val Asp Pro Thr Leu Arg Thr Lys Gln Pro Ile Pro Ala 
        275                 280                 285             


Ala Tyr Asn Arg Tyr Asp Gln Glu Arg Phe Lys Gly Lys Glu Glu Thr 
    290                 295                 300                 


Glu Gly Phe Lys Ile Asp Thr Met Gly Thr Tyr His Gly Met Thr Leu 
305                 310                 315                 320 


Lys Ser Val Thr Glu Gly Ala Ser Ala Arg Lys Thr Gln Thr Pro Ala 
                325                 330                 335     


Ala Gln Pro Val Pro Arg Pro Val Ser Gln Ala Arg Pro Pro Pro Asn 
            340                 345                 350         


Gln Lys Lys Gly Ser Arg Thr Pro Ile Ile Ile Ile Pro Ala Ala Thr 
        355                 360                 365             


Thr Ser Leu Ile Thr Met Leu Asn Ala Lys Asp Leu Leu Gln Asp Leu 
    370                 375                 380                 


Lys Phe Val Pro Ser Asp Glu Lys Lys Lys Gln Gly Cys Gln Arg Glu 
385                 390                 395                 400 


Asn Glu Thr Leu Ile Gln Arg Arg Lys Asp Gln Met Gln Pro Gly Gly 
                405                 410                 415     


Thr Ala Ile Ser Val Thr Val Pro Tyr Arg Val Val Asp Gln Pro Leu 
            420                 425                 430         


Lys Leu Met Pro Gln Asp Trp Asp Arg Val Val Ala Val Phe Val Gln 
        435                 440                 445             


Gly Pro Ala Trp Gln Phe Lys Gly Trp Pro Trp Leu Leu Pro Asp Gly 
    450                 455                 460                 


Ser Pro Val Asp Ile Phe Ala Lys Ile Lys Ala Phe His Leu Lys Tyr 
465                 470                 475                 480 


Asp Glu Val Arg Leu Asp Pro Asn Val Gln Lys Trp Asp Val Thr Val 
                485                 490                 495     


Leu Glu Leu Ser Tyr His Lys Arg His Leu Asp Arg Pro Val Phe Leu 
            500                 505                 510         


Arg Phe Trp Glu Thr Leu Asp Arg Tyr Met Val Lys His Lys Ser His 
        515                 520                 525             


Leu Arg Phe 
    530     


<210>  1890
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC7__Homo_sapiens__XP_011540528

<400>  1890

Met Glu Ala Ser Leu Gly Ile Gln Met Asp Glu Pro Met Ala Phe Ser 
1               5                   10                  15      


Pro Gln Arg Asp Arg Phe Gln Ala Glu Gly Ser Leu Lys Lys Asn Glu 
            20                  25                  30          


Gln Asn Phe Lys Leu Ala Gly Val Lys Lys Asp Ile Glu Lys Leu Tyr 
        35                  40                  45              


Glu Ala Val Pro Gln Leu Ser Asn Val Phe Lys Ile Glu Asp Lys Ile 
    50                  55                  60                  


Gly Glu Gly Thr Phe Ser Ser Val Tyr Leu Ala Thr Ala Gln Leu Gln 
65                  70                  75                  80  


Val Gly Pro Glu Glu Lys Ile Ala Leu Lys His Leu Ile Pro Thr Ser 
                85                  90                  95      


His Pro Ile Arg Ile Ala Ala Glu Leu Gln Cys Leu Thr Val Ala Gly 
            100                 105                 110         


Gly Gln Asp Asn Val Met Gly Val Lys Tyr Cys Phe Arg Lys Asn Asp 
        115                 120                 125             


His Val Val Ile Ala Met Pro Tyr Leu Glu His Glu Ser Phe Leu Asp 
    130                 135                 140                 


Ile Leu Asn Ser Leu Ser Phe Gln Glu Val Arg Glu Tyr Met Leu Asn 
145                 150                 155                 160 


Leu Phe Lys Ala Leu Lys Arg Ile His Gln Phe Gly Ile Val His Arg 
                165                 170                 175     


Asp Val Lys Pro Ser Asn Phe Leu Tyr Asn Arg Arg Leu Lys Lys Tyr 
            180                 185                 190         


Ala Leu Val Asp Phe Gly Leu Ala Gln Gly Thr His Asp Thr Lys Ile 
        195                 200                 205             


Glu Leu Leu Lys Phe Val Gln Ser Glu Ala Gln Gln Glu Arg Cys Ser 
    210                 215                 220                 


Gln Asn Lys Ser His Ile Ile Thr Gly Asn Lys Ile Pro Leu Ser Gly 
225                 230                 235                 240 


Pro Val Pro Lys Glu Leu Asp Gln Gln Ser Thr Thr Lys Ala Ser Val 
                245                 250                 255     


Lys Arg Pro Tyr Thr Asn Ala Gln Ile Gln Ile Lys Gln Gly Lys Asp 
            260                 265                 270         


Gly Lys Glu Gly Ser Val Gly Leu Ser Val Gln Arg Ser Val Phe Gly 
        275                 280                 285             


Glu Arg Asn Phe Asn Ile His Ser Ser Ile Ser His Glu Ser Pro Ala 
    290                 295                 300                 


Val Lys Leu Met Lys Gln Ser Lys Thr Val Asp Val Leu Ser Arg Lys 
305                 310                 315                 320 


Leu Ala Thr Lys Lys Lys Ala Ile Ser Thr Lys Val Met Asn Ser Ala 
                325                 330                 335     


Val Met Arg Lys Thr Ala Ser Ser Cys Pro Ala Ser Leu Thr Cys Asp 
            340                 345                 350         


Cys Tyr Ala Thr Asp Lys Val Cys Ser Ile Cys Leu Ser Arg Arg Gln 
        355                 360                 365             


Gln Val Ala Pro Arg Ala Gly Thr Pro Gly Phe Arg Ala Pro Glu Val 
    370                 375                 380                 


Leu Thr Lys Cys Pro Asn Gln Thr Thr Ala Ile Asp Met Trp Ser Ala 
385                 390                 395                 400 


Gly Val Ile Phe Leu Ser Leu Leu Ser Gly Arg Tyr Pro Phe Tyr Lys 
                405                 410                 415     


Ala Ser Asp Asp Leu Thr Ala Leu Ala Gln Ile Met Thr Ile Arg Gly 
            420                 425                 430         


Ser Arg Glu Thr Ile Gln Ala Ala Lys Thr Phe Gly Lys Ser Ile Leu 
        435                 440                 445             


Cys Ser Lys Glu Val Pro Ala Gln Asp Leu Arg Lys Leu Cys Glu Arg 
    450                 455                 460                 


Leu Arg Gly Met Asp Ser Ser Thr Pro Lys Leu Thr Ser Asp Ile Gln 
465                 470                 475                 480 


Gly His Ala Ser His Gln Pro Ala Ile Ser Glu Lys Thr Asp His Lys 
                485                 490                 495     


Ala Ser Cys Leu Val Gln Thr Pro Pro Gly Gln Tyr Ser Gly Asn Ser 
            500                 505                 510         


Phe Lys Lys Gly Asp Ser Asn Ser Cys Glu His Cys Phe Asp Glu Tyr 
        515                 520                 525             


Asn Thr Asn Leu Glu Gly Trp Asn Glu Val Pro Asp Glu Ala Tyr Asp 
    530                 535                 540                 


Leu Leu Asp Lys Leu Leu Asp Leu Asn Pro Ala Ser Arg Ile Thr Ala 
545                 550                 555                 560 


Glu Glu Ala Leu Leu His Pro Phe Phe Lys Asp Met Ser Leu 
                565                 570                 


<210>  1891
<211>  1023
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDCA2__Homo_sapiens__NP_689775

<400>  1891

Met Asp Ala Asn Ser Lys Asp Lys Pro Pro Glu Thr Lys Glu Ser Ala 
1               5                   10                  15      


Met Asn Asn Ala Gly Asn Ala Ser Phe Ile Leu Gly Thr Gly Lys Ile 
            20                  25                  30          


Val Thr Pro Gln Lys His Ala Glu Leu Pro Pro Asn Pro Cys Thr Pro 
        35                  40                  45              


Asp Thr Phe Lys Ser Pro Leu Asn Phe Ser Thr Val Thr Val Glu Gln 
    50                  55                  60                  


Leu Gly Ile Thr Pro Glu Ser Phe Val Arg Asn Ser Ala Gly Lys Ser 
65                  70                  75                  80  


Ser Ser Tyr Leu Lys Lys Cys Arg Arg Arg Ser Ala Val Gly Ala Arg 
                85                  90                  95      


Gly Ser Pro Glu Thr Asn His Leu Ile Arg Phe Ile Ala Arg Gln Gln 
            100                 105                 110         


Asn Ile Lys Asn Ala Arg Lys Ser Pro Leu Ala Gln Asp Ser Pro Ser 
        115                 120                 125             


Gln Gly Ser Pro Ala Leu Tyr Arg Asn Val Asn Thr Leu Arg Glu Arg 
    130                 135                 140                 


Ile Ser Ala Phe Gln Ser Ala Phe His Ser Ile Lys Glu Asn Glu Lys 
145                 150                 155                 160 


Met Thr Gly Cys Leu Glu Phe Ser Glu Ala Gly Lys Glu Ser Glu Met 
                165                 170                 175     


Thr Asp Leu Thr Arg Lys Glu Gly Leu Ser Ala Cys Gln Gln Ser Gly 
            180                 185                 190         


Phe Pro Ala Val Leu Ser Ser Lys Arg Arg Arg Ile Ser Tyr Gln Arg 
        195                 200                 205             


Asp Ser Asp Glu Asn Leu Thr Asp Ala Glu Gly Lys Val Ile Gly Leu 
    210                 215                 220                 


Gln Ile Phe Asn Ile Asp Thr Asp Arg Ala Cys Ala Val Glu Thr Ser 
225                 230                 235                 240 


Val Asp Leu Ser Glu Ile Ser Ser Lys Leu Gly Ser Thr Gln Ser Gly 
                245                 250                 255     


Phe Leu Val Glu Glu Ser Leu Pro Leu Ser Glu Leu Thr Glu Thr Ser 
            260                 265                 270         


Asn Ala Leu Lys Val Ala Asp Cys Val Val Gly Lys Gly Ser Ser Asp 
        275                 280                 285             


Ala Val Ser Pro Asp Thr Phe Thr Ala Glu Val Ser Ser Asp Ala Val 
    290                 295                 300                 


Pro Asp Val Arg Ser Pro Ala Thr Pro Ala Cys Arg Arg Asp Leu Pro 
305                 310                 315                 320 


Thr Pro Lys Thr Phe Val Leu Arg Ser Val Leu Lys Lys Pro Ser Val 
                325                 330                 335     


Lys Met Cys Leu Glu Ser Leu Gln Glu His Cys Asn Asn Leu Tyr Asp 
            340                 345                 350         


Asp Asp Gly Thr His Pro Ser Leu Ile Ser Asn Leu Pro Asn Cys Cys 
        355                 360                 365             


Lys Glu Lys Glu Ala Glu Asp Glu Glu Asn Phe Glu Ala Pro Ala Phe 
    370                 375                 380                 


Leu Asn Met Arg Lys Arg Lys Arg Val Thr Phe Gly Glu Asp Leu Ser 
385                 390                 395                 400 


Pro Glu Val Phe Asp Glu Ser Leu Pro Ala Asn Thr Pro Leu Arg Lys 
                405                 410                 415     


Gly Gly Thr Pro Val Cys Lys Lys Asp Phe Ser Gly Leu Ser Ser Leu 
            420                 425                 430         


Leu Leu Glu Gln Ser Pro Val Pro Glu Pro Leu Pro Gln Pro Asp Phe 
        435                 440                 445             


Asp Asp Lys Gly Glu Asn Leu Glu Asn Ile Glu Pro Leu Gln Val Ser 
    450                 455                 460                 


Phe Ala Val Leu Ser Ser Pro Asn Lys Ser Ser Ile Ser Glu Thr Leu 
465                 470                 475                 480 


Ser Gly Thr Asp Thr Phe Ser Ser Ser Asn Asn His Glu Lys Ile Ser 
                485                 490                 495     


Ser Pro Lys Val Gly Arg Ile Thr Arg Thr Ser Asn Arg Arg Asn Gln 
            500                 505                 510         


Leu Val Ser Val Val Glu Glu Ser Val Cys Asn Leu Leu Asn Thr Glu 
        515                 520                 525             


Val Gln Pro Cys Lys Glu Lys Lys Ile Asn Arg Arg Lys Ser Gln Glu 
    530                 535                 540                 


Thr Lys Cys Thr Lys Arg Ala Leu Pro Lys Lys Ser Gln Val Leu Lys 
545                 550                 555                 560 


Ser Cys Arg Lys Lys Lys Gly Lys Gly Lys Lys Ser Val Gln Lys Ser 
                565                 570                 575     


Leu Tyr Gly Glu Arg Asp Ile Ala Ser Lys Lys Pro Leu Leu Ser Pro 
            580                 585                 590         


Ile Pro Glu Leu Pro Glu Val Pro Glu Met Thr Pro Ser Ile Pro Ser 
        595                 600                 605             


Ile Arg Arg Leu Gly Ser Gly Tyr Phe Ser Ser Asn Gly Lys Leu Glu 
    610                 615                 620                 


Glu Val Lys Thr Pro Lys Asn Pro Val Lys Arg Lys Asp Leu Leu Arg 
625                 630                 635                 640 


His Asp Pro Asp Leu His Met His Gln Gly Tyr Asp Lys Tyr Asp Val 
                645                 650                 655     


Ser Glu Phe Cys Ser Tyr Ile Lys Ser Ser Ser Ser Leu Gly Asn Ala 
            660                 665                 670         


Thr Ser Asp Glu Asp Pro Asn Thr Asn Ile Met Asn Ile Asn Glu Asn 
        675                 680                 685             


Lys Asn Ile Pro Lys Ala Lys Asn Lys Ser Glu Ser Glu Asn Glu Pro 
    690                 695                 700                 


Lys Ala Gly Thr Asp Ser Pro Val Ser Cys Ala Ser Val Thr Glu Glu 
705                 710                 715                 720 


Arg Val Ala Ser Asp Ser Pro Lys Pro Ala Leu Thr Leu Gln Gln Gly 
                725                 730                 735     


Gln Glu Phe Ser Ala Gly Gly Gln Asn Ala Glu Asn Leu Cys Gln Phe 
            740                 745                 750         


Phe Lys Ile Ser Pro Asp Leu Asn Ile Lys Cys Glu Arg Lys Asp Asp 
        755                 760                 765             


Phe Leu Gly Ala Ala Glu Gly Lys Leu Gln Cys Asn Arg Leu Met Pro 
    770                 775                 780                 


Asn Ser Gln Lys Asp Cys His Cys Leu Gly Asp Val Leu Ile Glu Asn 
785                 790                 795                 800 


Thr Lys Glu Ser Lys Ser Gln Ser Glu Asp Leu Gly Arg Lys Pro Met 
                805                 810                 815     


Glu Ser Ser Ser Val Val Ser Cys Arg Asp Arg Lys Asp Arg Arg Arg 
            820                 825                 830         


Ser Met Cys Tyr Ser Asp Gly Arg Ser Leu His Leu Glu Lys Asn Gly 
        835                 840                 845             


Asn His Thr Pro Ser Ser Ser Val Gly Ser Ser Val Glu Ile Ser Leu 
    850                 855                 860                 


Glu Asn Ser Glu Leu Phe Lys Asp Leu Ser Asp Ala Ile Glu Gln Thr 
865                 870                 875                 880 


Phe Gln Arg Arg Asn Ser Glu Thr Lys Val Arg Arg Ser Thr Arg Leu 
                885                 890                 895     


Gln Lys Asp Leu Glu Asn Glu Gly Leu Val Trp Ile Ser Leu Pro Leu 
            900                 905                 910         


Pro Ser Thr Ser Gln Lys Ala Lys Arg Arg Thr Ile Cys Thr Phe Asp 
        915                 920                 925             


Ser Ser Gly Phe Glu Ser Met Ser Pro Ile Lys Glu Thr Val Ser Ser 
    930                 935                 940                 


Arg Gln Lys Pro Gln Met Ala Pro Pro Val Ser Asp Pro Glu Asn Ser 
945                 950                 955                 960 


Gln Gly Pro Ala Ala Gly Ser Ser Asp Glu Pro Gly Lys Arg Arg Lys 
                965                 970                 975     


Ser Phe Cys Ile Ser Thr Leu Ala Asn Thr Lys Ala Thr Ser Gln Phe 
            980                 985                 990         


Lys Gly Tyr Arg Arg Arg Ser Ser  Leu Asn Gly Lys Gly  Glu Ser Ser 
        995                 1000                 1005             


Leu Thr  Ala Leu Glu Arg Ile  Glu His Asn Gly Glu  Arg Lys Gln 
    1010                 1015                 1020             


<210>  1892
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDCA3__Homo_sapiens__NP_112589

<400>  1892

Met Gly Ser Ala Lys Ser Val Pro Val Thr Pro Ala Arg Pro Pro Pro 
1               5                   10                  15      


His Asn Lys His Leu Ala Arg Val Ala Asp Pro Arg Ser Pro Ser Ala 
            20                  25                  30          


Gly Ile Leu Arg Thr Pro Ile Gln Val Glu Ser Ser Pro Gln Pro Gly 
        35                  40                  45              


Leu Pro Ala Gly Glu Gln Leu Glu Gly Leu Lys His Ala Gln Asp Ser 
    50                  55                  60                  


Asp Pro Arg Ser Pro Thr Leu Gly Ile Ala Arg Thr Pro Met Lys Thr 
65                  70                  75                  80  


Ser Ser Gly Asp Pro Pro Ser Pro Leu Val Lys Gln Leu Ser Glu Val 
                85                  90                  95      


Phe Glu Thr Glu Asp Ser Lys Ser Asn Leu Pro Pro Glu Pro Val Leu 
            100                 105                 110         


Pro Pro Glu Ala Pro Leu Ser Ser Glu Leu Asp Leu Pro Leu Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Glu Glu Gln Met Pro Pro Trp Asn Gln Thr Glu Phe 
    130                 135                 140                 


Pro Ser Lys Gln Val Phe Ser Lys Glu Glu Ala Arg Gln Pro Thr Glu 
145                 150                 155                 160 


Thr Pro Val Ala Ser Gln Ser Ser Asp Lys Pro Ser Arg Asp Pro Glu 
                165                 170                 175     


Thr Pro Arg Ser Ser Gly Ser Met Arg Asn Arg Trp Lys Pro Asn Ser 
            180                 185                 190         


Ser Lys Val Leu Gly Arg Ser Pro Leu Thr Ile Leu Gln Asp Asp Asn 
        195                 200                 205             


Ser Pro Gly Thr Leu Thr Leu Arg Gln Gly Lys Arg Pro Ser Pro Leu 
    210                 215                 220                 


Ser Glu Asn Val Ser Glu Leu Lys Glu Gly Ala Ile Leu Gly Thr Gly 
225                 230                 235                 240 


Arg Leu Leu Lys Thr Gly Gly Arg Ala Trp Glu Gln Gly Gln Asp His 
                245                 250                 255     


Asp Lys Glu Asn Gln His Phe Pro Leu Val Glu Ser 
            260                 265             


<210>  1893
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDCA5__Homo_sapiens__NP_542399

<400>  1893

Met Ser Gly Arg Arg Thr Arg Ser Gly Gly Ala Ala Gln Arg Ser Gly 
1               5                   10                  15      


Pro Arg Ala Pro Ser Pro Thr Lys Pro Leu Arg Arg Ser Gln Arg Lys 
            20                  25                  30          


Ser Gly Ser Glu Leu Pro Ser Ile Leu Pro Glu Ile Trp Pro Lys Thr 
        35                  40                  45              


Pro Ser Ala Ala Ala Val Arg Lys Pro Ile Val Leu Lys Arg Ile Val 
    50                  55                  60                  


Ala His Ala Val Glu Val Pro Ala Val Gln Ser Pro Arg Arg Ser Pro 
65                  70                  75                  80  


Arg Ile Ser Phe Phe Leu Glu Lys Glu Asn Glu Pro Pro Gly Arg Glu 
                85                  90                  95      


Leu Thr Lys Glu Asp Leu Phe Lys Thr His Ser Val Pro Ala Thr Pro 
            100                 105                 110         


Thr Ser Thr Pro Val Pro Asn Pro Glu Ala Glu Ser Ser Ser Lys Glu 
        115                 120                 125             


Gly Glu Leu Asp Ala Arg Asp Leu Glu Met Ser Lys Lys Val Arg Arg 
    130                 135                 140                 


Ser Tyr Ser Arg Leu Glu Thr Leu Gly Ser Ala Ser Thr Ser Thr Pro 
145                 150                 155                 160 


Gly Arg Arg Ser Cys Phe Gly Phe Glu Gly Leu Leu Gly Ala Glu Asp 
                165                 170                 175     


Leu Ser Gly Val Ser Pro Val Val Cys Ser Lys Leu Thr Glu Val Pro 
            180                 185                 190         


Arg Val Cys Ala Lys Pro Trp Ala Pro Asp Met Thr Leu Pro Gly Ile 
        195                 200                 205             


Ser Pro Pro Pro Glu Lys Gln Lys Arg Lys Lys Lys Lys Met Pro Glu 
    210                 215                 220                 


Ile Leu Lys Thr Glu Leu Asp Glu Trp Ala Ala Ala Met Asn Ala Glu 
225                 230                 235                 240 


Phe Glu Ala Ala Glu Gln Phe Asp Leu Leu Val Glu 
                245                 250         


<210>  1894
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDCA7__Homo_sapiens__NP_114148

<400>  1894

Met Asp Ala Arg Arg Val Pro Gln Lys Asp Leu Arg Val Lys Lys Asn 
1               5                   10                  15      


Leu Lys Lys Phe Arg Tyr Val Lys Leu Ile Ser Met Glu Thr Ser Ser 
            20                  25                  30          


Ser Ser Asp Asp Ser Cys Asp Ser Phe Ala Ser Asp Asn Phe Ala Asn 
        35                  40                  45              


Thr Lys Pro Lys Phe Arg Ser Asp Ile Ser Glu Glu Leu Ala Asn Val 
    50                  55                  60                  


Phe Tyr Glu Asp Ser Asp Asn Glu Ser Phe Cys Gly Phe Ser Glu Ser 
65                  70                  75                  80  


Glu Val Gln Asp Val Leu Asp His Cys Gly Phe Leu Gln Lys Pro Arg 
                85                  90                  95      


Pro Asp Val Thr Asn Glu Leu Ala Gly Ile Phe His Ala Asp Ser Asp 
            100                 105                 110         


Asp Glu Ser Phe Cys Gly Phe Ser Glu Ser Glu Ile Gln Asp Gly Met 
        115                 120                 125             


Arg Leu Gln Ser Val Arg Glu Gly Cys Arg Thr Arg Ser Gln Cys Arg 
    130                 135                 140                 


His Ser Gly Pro Leu Arg Val Ala Met Lys Phe Pro Ala Arg Ser Thr 
145                 150                 155                 160 


Arg Gly Ala Thr Asn Lys Lys Ala Glu Ser Arg Gln Pro Ser Glu Asn 
                165                 170                 175     


Ser Val Thr Asp Ser Asn Ser Asp Ser Glu Asp Glu Ser Gly Met Asn 
            180                 185                 190         


Phe Leu Glu Lys Arg Ala Leu Asn Ile Lys Gln Asn Lys Ala Met Leu 
        195                 200                 205             


Ala Lys Leu Met Ser Glu Leu Glu Ser Phe Pro Gly Ser Phe Arg Gly 
    210                 215                 220                 


Arg His Pro Leu Pro Gly Ser Asp Ser Gln Ser Arg Arg Pro Arg Arg 
225                 230                 235                 240 


Arg Thr Phe Pro Gly Val Ala Ser Arg Arg Asn Pro Glu Arg Arg Ala 
                245                 250                 255     


Arg Pro Leu Thr Arg Ser Arg Ser Arg Ile Leu Gly Ser Leu Asp Ala 
            260                 265                 270         


Leu Pro Met Glu Glu Glu Glu Glu Glu Asp Lys Tyr Met Leu Val Arg 
        275                 280                 285             


Lys Arg Lys Thr Val Asp Gly Tyr Met Asn Glu Asp Asp Leu Pro Arg 
    290                 295                 300                 


Ser Arg Arg Ser Arg Ser Ser Val Thr Leu Pro His Ile Ile Arg Pro 
305                 310                 315                 320 


Val Glu Glu Ile Thr Glu Glu Glu Leu Glu Asn Val Cys Ser Asn Ser 
                325                 330                 335     


Arg Glu Lys Ile Tyr Asn Arg Ser Leu Gly Ser Thr Cys His Gln Cys 
            340                 345                 350         


Arg Gln Lys Thr Ile Asp Thr Lys Thr Asn Cys Arg Asn Pro Asp Cys 
        355                 360                 365             


Trp Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu Arg Asn Arg Tyr 
    370                 375                 380                 


Gly Glu Glu Val Arg Asp Ala Leu Leu Asp Pro Asn Trp His Cys Pro 
385                 390                 395                 400 


Pro Cys Arg Gly Ile Cys Asn Cys Ser Phe Cys Arg Gln Arg Asp Gly 
                405                 410                 415     


Arg Cys Ala Thr Gly Val Leu Val Tyr Leu Ala Lys Tyr His Gly Phe 
            420                 425                 430         


Gly Asn Val His Ala Tyr Leu Lys Ser Leu Lys Gln Glu Phe Glu Met 
        435                 440                 445             


Gln Ala 
    450 


<210>  1895
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDCA7L__Homo_sapiens__NP_001120842

<400>  1895

Met Glu Thr Leu Ser Ser Glu Glu Ser Cys Asp Ser Phe Asp Ser Leu 
1               5                   10                  15      


Glu Ser Gly Lys Gln Gln Asp Val Arg Phe His Ser Lys Tyr Phe Thr 
            20                  25                  30          


Glu Glu Leu Arg Arg Ile Phe Ile Glu Asp Thr Asp Ser Glu Thr Glu 
        35                  40                  45              


Asp Phe Ala Gly Phe Thr Gln Ser Asp Leu Asn Gly Lys Thr Asn Pro 
    50                  55                  60                  


Glu Val Met Val Val Glu Ser Asp Leu Ser Asp Asp Gly Lys Ala Ser 
65                  70                  75                  80  


Leu Val Ser Glu Glu Glu Glu Asp Glu Glu Glu Asp Lys Ala Thr Pro 
                85                  90                  95      


Arg Arg Ser Arg Ser Arg Arg Ser Ser Ile Gly Leu Arg Val Ala Phe 
            100                 105                 110         


Gln Phe Pro Thr Lys Lys Leu Ala Asn Lys Pro Asp Lys Asn Ser Ser 
        115                 120                 125             


Ser Glu Gln Leu Phe Ser Ser Ala Arg Leu Gln Asn Glu Lys Lys Thr 
    130                 135                 140                 


Ile Leu Glu Arg Lys Lys Asp Cys Arg Gln Val Ile Gln Arg Glu Asp 
145                 150                 155                 160 


Ser Thr Ser Glu Ser Glu Asp Asp Ser Arg Asp Glu Ser Gln Glu Ser 
                165                 170                 175     


Ser Asp Ala Leu Leu Lys Arg Thr Met Asn Ile Lys Glu Asn Lys Ala 
            180                 185                 190         


Met Leu Ala Gln Leu Leu Ala Glu Leu Asn Ser Met Pro Asp Phe Phe 
        195                 200                 205             


Pro Val Arg Thr Pro Thr Ser Ala Ser Arg Lys Lys Thr Val Arg Arg 
    210                 215                 220                 


Ala Phe Ser Glu Gly Gln Ile Thr Arg Arg Met Asn Pro Thr Arg Ser 
225                 230                 235                 240 


Ala Arg Pro Pro Glu Lys Phe Ala Leu Glu Asn Phe Thr Val Ser Ala 
                245                 250                 255     


Ala Lys Phe Ala Glu Glu Phe Tyr Ser Phe Arg Arg Arg Lys Thr Ile 
            260                 265                 270         


Gly Gly Lys Cys Arg Glu Tyr Arg Arg Arg His Arg Ile Ser Ser Phe 
        275                 280                 285             


Arg Pro Val Glu Asp Ile Thr Glu Glu Asp Leu Glu Asn Val Ala Ile 
    290                 295                 300                 


Thr Val Arg Asp Lys Ile Tyr Asp Lys Val Leu Gly Asn Thr Cys His 
305                 310                 315                 320 


Gln Cys Arg Gln Lys Thr Ile Asp Thr Lys Thr Val Cys Arg Asn Gln 
                325                 330                 335     


Gly Cys Cys Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu Arg Asn 
            340                 345                 350         


Arg Tyr Gly Glu Asp Val Arg Ser Ala Leu Leu Asp Pro Asp Trp Val 
        355                 360                 365             


Cys Pro Pro Cys Arg Gly Ile Cys Asn Cys Ser Tyr Cys Arg Lys Arg 
    370                 375                 380                 


Asp Gly Arg Cys Ala Thr Gly Ile Leu Ile His Leu Ala Lys Phe Tyr 
385                 390                 395                 400 


Gly Tyr Asp Asn Val Lys Glu Tyr Leu Glu Ser Leu Gln Lys Glu Leu 
                405                 410                 415     


Val Glu Asp Asn 
            420 


<210>  1896
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDCP1__Homo_sapiens__NP_073753

<400>  1896

Met Ala Gly Leu Asn Cys Gly Val Ser Ile Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Arg Leu Pro Arg Gly Ala Glu Ala Phe Glu Ile 
            20                  25                  30          


Ala Leu Pro Arg Glu Ser Asn Ile Thr Val Leu Ile Lys Leu Gly Thr 
        35                  40                  45              


Pro Thr Leu Leu Ala Lys Pro Cys Tyr Ile Val Ile Ser Lys Arg His 
    50                  55                  60                  


Ile Thr Met Leu Ser Ile Lys Ser Gly Glu Arg Ile Val Phe Thr Phe 
65                  70                  75                  80  


Ser Cys Gln Ser Pro Glu Asn His Phe Val Ile Glu Ile Gln Lys Asn 
                85                  90                  95      


Ile Asp Cys Met Ser Gly Pro Cys Pro Phe Gly Glu Val Gln Leu Gln 
            100                 105                 110         


Pro Ser Thr Ser Leu Leu Pro Thr Leu Asn Arg Thr Phe Ile Trp Asp 
        115                 120                 125             


Val Lys Ala His Lys Ser Ile Gly Leu Glu Leu Gln Phe Ser Ile Pro 
    130                 135                 140                 


Arg Leu Arg Gln Ile Gly Pro Gly Glu Ser Cys Pro Asp Gly Val Thr 
145                 150                 155                 160 


His Ser Ile Ser Gly Arg Ile Asp Ala Thr Val Val Arg Ile Gly Thr 
                165                 170                 175     


Phe Cys Ser Asn Gly Thr Val Ser Arg Ile Lys Met Gln Glu Gly Val 
            180                 185                 190         


Lys Met Ala Leu His Leu Pro Trp Phe His Pro Arg Asn Val Ser Gly 
        195                 200                 205             


Phe Ser Ile Ala Asn Arg Ser Ser Ile Lys Arg Leu Cys Ile Ile Glu 
    210                 215                 220                 


Ser Val Phe Glu Gly Glu Gly Ser Ala Thr Leu Met Ser Ala Asn Tyr 
225                 230                 235                 240 


Pro Glu Gly Phe Pro Glu Asp Glu Leu Met Thr Trp Gln Phe Val Val 
                245                 250                 255     


Pro Ala His Leu Arg Ala Ser Val Ser Phe Leu Asn Phe Asn Leu Ser 
            260                 265                 270         


Asn Cys Glu Arg Lys Glu Glu Arg Val Glu Tyr Tyr Ile Pro Gly Ser 
        275                 280                 285             


Thr Thr Asn Pro Glu Val Phe Lys Leu Glu Asp Lys Gln Pro Gly Asn 
    290                 295                 300                 


Met Ala Gly Asn Phe Asn Leu Ser Leu Gln Gly Cys Asp Gln Asp Ala 
305                 310                 315                 320 


Gln Ser Pro Gly Ile Leu Arg Leu Gln Phe Gln Val Leu Val Gln His 
                325                 330                 335     


Pro Gln Asn Glu Ser Asn Lys Ile Tyr Val Val Asp Leu Ser Asn Glu 
            340                 345                 350         


Arg Ala Met Ser Leu Thr Ile Glu Pro Arg Pro Val Lys Gln Ser Arg 
        355                 360                 365             


Lys Phe Val Pro Gly Cys Phe Val Cys Leu Glu Ser Arg Thr Cys Ser 
    370                 375                 380                 


Ser Asn Leu Thr Leu Thr Ser Gly Ser Lys His Lys Ile Ser Phe Leu 
385                 390                 395                 400 


Cys Asp Asp Leu Thr Arg Leu Trp Met Asn Val Glu Lys Thr Ile Ser 
                405                 410                 415     


Cys Thr Asp His Arg Tyr Cys Gln Arg Lys Ser Tyr Ser Leu Gln Val 
            420                 425                 430         


Pro Ser Asp Ile Leu His Leu Pro Val Glu Leu His Asp Phe Ser Trp 
        435                 440                 445             


Lys Leu Leu Val Pro Lys Asp Arg Leu Ser Leu Val Leu Val Pro Ala 
    450                 455                 460                 


Gln Lys Leu Gln Gln His Thr His Glu Lys Pro Cys Asn Thr Ser Phe 
465                 470                 475                 480 


Ser Tyr Leu Val Ala Ser Ala Ile Pro Ser Gln Asp Leu Tyr Phe Gly 
                485                 490                 495     


Ser Phe Cys Pro Gly Gly Ser Ile Lys Gln Ile Gln Val Lys Gln Asn 
            500                 505                 510         


Ile Ser Val Thr Leu Arg Thr Phe Ala Pro Ser Phe Gln Gln Glu Ala 
        515                 520                 525             


Ser Arg Gln Gly Leu Thr Val Ser Phe Ile Pro Tyr Phe Lys Glu Glu 
    530                 535                 540                 


Gly Val Phe Thr Val Thr Pro Asp Thr Lys Ser Lys Val Tyr Leu Arg 
545                 550                 555                 560 


Thr Pro Asn Trp Asp Arg Gly Leu Pro Ser Leu Thr Ser Val Ser Trp 
                565                 570                 575     


Asn Ile Ser Val Pro Arg Asp Gln Val Ala Cys Leu Thr Phe Phe Lys 
            580                 585                 590         


Glu Arg Ser Gly Val Val Cys Gln Thr Gly Arg Ala Phe Met Ile Ile 
        595                 600                 605             


Gln Glu Gln Arg Thr Arg Ala Glu Glu Ile Phe Ser Leu Asp Glu Asp 
    610                 615                 620                 


Val Leu Pro Lys Pro Ser Phe His His His Ser Phe Trp Val Asn Ile 
625                 630                 635                 640 


Ser Asn Cys Ser Pro Thr Ser Gly Lys Gln Leu Asp Leu Leu Phe Ser 
                645                 650                 655     


Val Thr Leu Thr Pro Arg Thr Val Asp Leu Thr Val Ile Leu Ile Ala 
            660                 665                 670         


Ala Val Gly Gly Gly Val Leu Leu Leu Ser Ala Leu Gly Leu Ile Ile 
        675                 680                 685             


Cys Cys Val Lys Lys Lys Lys Lys Lys Thr Asn Lys Gly Pro Ala Val 
    690                 695                 700                 


Gly Ile Tyr Asn Asp Asn Ile Asn Thr Glu Met Pro Arg Gln Pro Lys 
705                 710                 715                 720 


Lys Phe Gln Lys Gly Arg Lys Asp Asn Asp Ser His Val Tyr Ala Val 
                725                 730                 735     


Ile Glu Asp Thr Met Val Tyr Gly His Leu Leu Gln Asp Ser Ser Gly 
            740                 745                 750         


Ser Phe Leu Gln Pro Glu Val Asp Thr Tyr Arg Pro Phe Gln Gly Thr 
        755                 760                 765             


Met Gly Val Cys Pro Pro Ser Pro Pro Thr Ile Cys Ser Arg Ala Pro 
    770                 775                 780                 


Thr Ala Lys Leu Ala Thr Glu Glu Pro Pro Pro Arg Ser Pro Pro Glu 
785                 790                 795                 800 


Ser Glu Ser Glu Pro Tyr Thr Phe Ser His Pro Asn Asn Gly Asp Val 
                805                 810                 815     


Ser Ser Lys Asp Thr Asp Ile Pro Leu Leu Asn Thr Gln Glu Pro Met 
            820                 825                 830         


Glu Pro Ala Glu 
        835     


<210>  1897
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH10__Homo_sapiens__NP_006718

<400>  1897

Met Thr Ile His Gln Phe Leu Leu Leu Phe Leu Phe Trp Val Cys Leu 
1               5                   10                  15      


Pro His Phe Cys Ser Pro Glu Ile Met Phe Arg Arg Thr Pro Val Pro 
            20                  25                  30          


Gln Gln Arg Ile Leu Ser Ser Arg Val Pro Arg Ser Asp Gly Lys Ile 
        35                  40                  45              


Leu His Arg Gln Lys Arg Gly Trp Met Trp Asn Gln Phe Phe Leu Leu 
    50                  55                  60                  


Glu Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser 
65                  70                  75                  80  


Asp Gln Asp Lys Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp 
                85                  90                  95      


Gly Ala Gly Thr Leu Phe Ile Ile Asp Glu Lys Thr Gly Asp Ile His 
            100                 105                 110         


Ala Thr Arg Arg Ile Asp Arg Glu Glu Lys Ala Phe Tyr Thr Leu Arg 
        115                 120                 125             


Ala Gln Ala Ile Asn Arg Arg Thr Leu Arg Pro Val Glu Pro Glu Ser 
    130                 135                 140                 


Glu Phe Val Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Thr Phe 
145                 150                 155                 160 


Pro Glu Glu Ile Tyr Thr Ala Ser Val Pro Glu Met Ser Val Val Gly 
                165                 170                 175     


Thr Ser Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Ser Tyr 
            180                 185                 190         


Gly Asn Ser Ala Arg Val Ile Tyr Ser Ile Leu Gln Gly Gln Pro Tyr 
        195                 200                 205             


Phe Ser Val Glu Pro Glu Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn 
    210                 215                 220                 


Met Asn Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys 
225                 230                 235                 240 


Asp Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn 
                245                 250                 255     


Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Asn 
            260                 265                 270         


Thr Ile His Leu Arg Val Leu Glu Ser Ser Pro Val Gly Thr Ala Ile 
        275                 280                 285             


Gly Ser Val Lys Ala Thr Asp Ala Asp Thr Gly Lys Asn Ala Glu Val 
    290                 295                 300                 


Glu Tyr Arg Ile Ile Asp Gly Asp Gly Thr Asp Met Phe Asp Ile Val 
305                 310                 315                 320 


Thr Glu Lys Asp Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Pro Leu 
                325                 330                 335     


Asp Tyr Glu Ser Arg Arg Leu Tyr Thr Leu Lys Val Glu Ala Glu Asn 
            340                 345                 350         


Thr His Val Asp Pro Arg Phe Tyr Tyr Leu Gly Pro Phe Lys Asp Thr 
        355                 360                 365             


Thr Ile Val Lys Ile Ser Ile Glu Asp Val Asp Glu Pro Pro Val Phe 
    370                 375                 380                 


Ser Arg Ser Ser Tyr Leu Phe Glu Val His Glu Asp Ile Glu Val Gly 
385                 390                 395                 400 


Thr Ile Ile Gly Thr Val Met Ala Arg Asp Pro Asp Ser Ile Ser Ser 
                405                 410                 415     


Pro Ile Arg Phe Ser Leu Asp Arg His Thr Asp Leu Asp Arg Ile Phe 
            420                 425                 430         


Asn Ile His Ser Gly Asn Gly Ser Leu Tyr Thr Ser Lys Pro Leu Asp 
        435                 440                 445             


Arg Glu Leu Ser Gln Trp His Asn Leu Thr Val Ile Ala Ala Glu Ile 
    450                 455                 460                 


Asn Asn Pro Lys Glu Thr Thr Arg Val Ala Val Phe Val Arg Ile Leu 
465                 470                 475                 480 


Asp Val Asn Asp Asn Ala Pro Gln Phe Ala Val Phe Tyr Asp Thr Phe 
                485                 490                 495     


Val Cys Glu Asn Ala Arg Pro Gly Gln Leu Ile Gln Thr Ile Ser Ala 
            500                 505                 510         


Val Asp Lys Asp Asp Pro Leu Gly Gly Gln Lys Phe Phe Phe Ser Leu 
        515                 520                 525             


Ala Ala Val Asn Pro Asn Phe Thr Val Gln Asp Asn Glu Asp Asn Thr 
    530                 535                 540                 


Ala Arg Ile Leu Thr Arg Lys Asn Gly Phe Asn Arg His Glu Ile Ser 
545                 550                 555                 560 


Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro Ile Gln 
                565                 570                 575     


Ser Ser Thr Gly Thr Leu Thr Ile Arg Val Cys Ala Cys Asp Ser Gln 
            580                 585                 590         


Gly Asn Met Gln Ser Cys Ser Ala Glu Ala Leu Leu Leu Pro Ala Gly 
        595                 600                 605             


Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu 
    610                 615                 620                 


Leu Val Ile Val Val Leu Phe Ala Ala Leu Lys Arg Gln Arg Lys Lys 
625                 630                 635                 640 


Glu Pro Leu Ile Leu Ser Lys Glu Asp Ile Arg Asp Asn Ile Val Ser 
                645                 650                 655     


Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe Asp Ile 
            660                 665                 670         


Gly Thr Leu Arg Asn Pro Ala Ala Ile Glu Glu Lys Lys Leu Arg Arg 
        675                 680                 685             


Asp Ile Ile Pro Glu Thr Leu Phe Ile Pro Arg Arg Thr Pro Thr Ala 
    690                 695                 700                 


Pro Asp Asn Thr Asp Val Arg Asp Phe Ile Asn Glu Arg Leu Lys Glu 
705                 710                 715                 720 


His Asp Leu Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Ala Thr Tyr 
                725                 730                 735     


Ala Tyr Glu Gly Asn Asp Ser Ile Ala Glu Ser Leu Ser Ser Leu Glu 
            740                 745                 750         


Ser Gly Thr Thr Glu Gly Asp Gln Asn Tyr Asp Tyr Leu Arg Glu Trp 
        755                 760                 765             


Gly Pro Arg Phe Asn Lys Leu Ala Glu Met Tyr Gly Gly Gly Glu Ser 
    770                 775                 780                 


Asp Lys Asp Ser 
785             


<210>  1898
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH11__Homo_sapiens__NP_001788

<400>  1898

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu 
625                 630                 635                 640 


Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Val 
                645                 650                 655     


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
            660                 665                 670         


Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn 
        675                 680                 685             


Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr Met Pro 
    690                 695                 700                 


Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe 
705                 710                 715                 720 


Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala Pro Pro 
                725                 730                 735     


Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala 
            740                 745                 750         


Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp Leu Asp 
        755                 760                 765             


Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp 
    770                 775                 780                 


Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
785                 790                 795     


<210>  1899
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH13__Homo_sapiens__NP_001207417

<400>  1899

Met Lys Thr Pro Pro Gly Ala Ser Ser Arg Thr Lys Cys Ser Arg Glu 
1               5                   10                  15      


Leu Arg Ser Phe Cys Ala Phe Ser Cys Pro Arg Ala Lys Gln Pro Thr 
            20                  25                  30          


Cys Thr Ala Trp Phe Pro Gln Gln Glu His Pro Ser Glu Asn Gly Pro 
        35                  40                  45              


Gln Met Pro Gly Arg Asp Pro Pro Ala Ala Ser Thr Met Gln Val Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln Gln 
65                  70                  75                  80  


Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln Ser 
                85                  90                  95      


Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu Arg 
            100                 105                 110         


Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly Leu 
        115                 120                 125             


Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val His 
    130                 135                 140                 


Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val Gly 
145                 150                 155                 160 


Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala Arg 
                165                 170                 175     


Thr Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro Ile 
            180                 185                 190         


Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly Lys 
        195                 200                 205             


Val Val Asp Ser Asp Arg Pro Glu Arg Ser Lys Phe Arg Leu Thr Gly 
    210                 215                 220                 


Lys Gly Val Asp Gln Glu Pro Lys Gly Ile Phe Arg Ile Asn Glu Asn 
225                 230                 235                 240 


Thr Gly Ser Val Ser Val Thr Arg Thr Leu Asp Arg Glu Val Ile Ala 
                245                 250                 255     


Val Tyr Gln Leu Phe Val Glu Thr Thr Asp Val Asn Gly Lys Thr Leu 
            260                 265                 270         


Glu Gly Pro Val Pro Leu Glu Val Ile Val Ile Asp Gln Asn Asp Asn 
        275                 280                 285             


Arg Pro Ile Phe Arg Glu Gly Pro Tyr Ile Gly His Val Met Glu Gly 
    290                 295                 300                 


Ser Pro Thr Gly Thr Thr Val Met Arg Met Thr Ala Phe Asp Ala Asp 
305                 310                 315                 320 


Asp Pro Ala Thr Asp Asn Ala Leu Leu Arg Tyr Asn Ile Arg Gln Gln 
                325                 330                 335     


Thr Pro Asp Lys Pro Ser Pro Asn Met Phe Tyr Ile Asp Pro Glu Lys 
            340                 345                 350         


Gly Asp Ile Val Thr Val Val Ser Pro Ala Leu Leu Asp Arg Glu Thr 
        355                 360                 365             


Leu Glu Asn Pro Lys Tyr Glu Leu Ile Ile Glu Ala Gln Asp Met Ala 
    370                 375                 380                 


Gly Leu Asp Val Gly Leu Thr Gly Thr Ala Thr Ala Thr Ile Met Ile 
385                 390                 395                 400 


Asp Asp Lys Asn Asp His Ser Pro Lys Phe Thr Lys Lys Glu Phe Gln 
                405                 410                 415     


Ala Thr Val Glu Glu Gly Ala Val Gly Val Ile Val Asn Leu Thr Val 
            420                 425                 430         


Glu Asp Lys Asp Asp Pro Thr Thr Gly Ala Trp Arg Ala Ala Tyr Thr 
        435                 440                 445             


Ile Ile Asn Gly Asn Pro Gly Gln Ser Phe Glu Ile His Thr Asn Pro 
    450                 455                 460                 


Gln Thr Asn Glu Gly Met Leu Ser Val Val Lys Pro Leu Asp Tyr Glu 
465                 470                 475                 480 


Ile Ser Ala Phe His Thr Leu Leu Ile Lys Val Glu Asn Glu Asp Pro 
                485                 490                 495     


Leu Val Pro Asp Val Ser Tyr Gly Pro Ser Ser Thr Ala Thr Val His 
            500                 505                 510         


Ile Thr Val Leu Asp Val Asn Glu Gly Pro Val Phe Tyr Pro Asp Pro 
        515                 520                 525             


Met Met Val Thr Arg Gln Glu Asp Leu Ser Val Gly Ser Val Leu Leu 
    530                 535                 540                 


Thr Val Asn Ala Thr Asp Pro Asp Ser Leu Gln His Gln Thr Ile Arg 
545                 550                 555                 560 


Tyr Ser Val Tyr Lys Asp Pro Ala Gly Trp Leu Asn Ile Asn Pro Ile 
                565                 570                 575     


Asn Gly Thr Val Asp Thr Thr Ala Val Leu Asp Arg Glu Ser Pro Phe 
            580                 585                 590         


Val Asp Asn Ser Val Tyr Thr Ala Leu Phe Leu Ala Ile Asp Ser Gly 
        595                 600                 605             


Asn Pro Pro Ala Thr Gly Thr Gly Thr Leu Leu Ile Thr Leu Glu Asp 
    610                 615                 620                 


Val Asn Asp Asn Ala Pro Phe Ile Tyr Pro Thr Val Ala Glu Val Cys 
625                 630                 635                 640 


Asp Asp Ala Lys Asn Leu Ser Val Val Ile Leu Gly Ala Ser Asp Lys 
                645                 650                 655     


Asp Leu His Pro Asn Thr Asp Pro Phe Lys Phe Glu Ile His Lys Gln 
            660                 665                 670         


Ala Val Pro Asp Lys Val Trp Lys Ile Ser Lys Ile Asn Asn Thr His 
        675                 680                 685             


Ala Leu Val Ser Leu Leu Gln Asn Leu Asn Lys Ala Asn Tyr Asn Leu 
    690                 695                 700                 


Pro Ile Met Val Thr Asp Ser Gly Lys Pro Pro Met Thr Asn Ile Thr 
705                 710                 715                 720 


Asp Leu Arg Val Gln Val Cys Ser Cys Arg Asn Ser Lys Val Asp Cys 
                725                 730                 735     


Asn Ala Ala Gly Ala Leu Arg Phe Ser Leu Pro Ser Val Leu Leu Leu 
            740                 745                 750         


Ser Leu Phe Ser Leu Ala Cys Leu 
        755                 760 


<210>  1900
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH15__Homo_sapiens__NP_004924

<400>  1900

Met Asp Ala Ala Phe Leu Leu Val Leu Gly Leu Leu Ala Gln Ser Leu 
1               5                   10                  15      


Cys Leu Ser Leu Gly Val Pro Gly Trp Arg Arg Pro Thr Thr Leu Tyr 
            20                  25                  30          


Pro Trp Arg Arg Ala Pro Ala Leu Ser Arg Val Arg Arg Ala Trp Val 
        35                  40                  45              


Ile Pro Pro Ile Ser Val Ser Glu Asn His Lys Arg Leu Pro Tyr Pro 
    50                  55                  60                  


Leu Val Gln Ile Lys Ser Asp Lys Gln Gln Leu Gly Ser Val Ile Tyr 
65                  70                  75                  80  


Ser Ile Gln Gly Pro Gly Val Asp Glu Glu Pro Arg Gly Val Phe Ser 
                85                  90                  95      


Ile Asp Lys Phe Thr Gly Lys Val Phe Leu Asn Ala Met Leu Asp Arg 
            100                 105                 110         


Glu Lys Thr Asp Arg Phe Arg Leu Arg Ala Phe Ala Leu Asp Leu Gly 
        115                 120                 125             


Gly Ser Thr Leu Glu Asp Pro Thr Asp Leu Glu Ile Val Val Val Asp 
    130                 135                 140                 


Gln Asn Asp Asn Arg Pro Ala Phe Leu Gln Glu Ala Phe Thr Gly Arg 
145                 150                 155                 160 


Val Leu Glu Gly Ala Val Pro Gly Thr Tyr Val Thr Arg Ala Glu Ala 
                165                 170                 175     


Thr Asp Ala Asp Asp Pro Glu Thr Asp Asn Ala Ala Leu Arg Phe Ser 
            180                 185                 190         


Ile Leu Gln Gln Gly Ser Pro Glu Leu Phe Ser Ile Asp Glu Leu Thr 
        195                 200                 205             


Gly Glu Ile Arg Thr Val Gln Val Gly Leu Asp Arg Glu Val Val Ala 
    210                 215                 220                 


Val Tyr Asn Leu Thr Leu Gln Val Ala Asp Met Ser Gly Asp Gly Leu 
225                 230                 235                 240 


Thr Ala Thr Ala Ser Ala Ile Ile Thr Leu Asp Asp Ile Asn Asp Asn 
                245                 250                 255     


Ala Pro Glu Phe Thr Arg Asp Glu Phe Phe Met Glu Ala Ile Glu Ala 
            260                 265                 270         


Val Ser Gly Val Asp Val Gly Arg Leu Glu Val Glu Asp Arg Asp Leu 
        275                 280                 285             


Pro Gly Ser Pro Asn Trp Val Ala Arg Phe Thr Ile Leu Glu Gly Asp 
    290                 295                 300                 


Pro Asp Gly Gln Phe Thr Ile Arg Thr Asp Pro Lys Thr Asn Glu Gly 
305                 310                 315                 320 


Val Leu Ser Ile Val Lys Ala Leu Asp Tyr Glu Ser Cys Glu His Tyr 
                325                 330                 335     


Glu Leu Lys Val Ser Val Gln Asn Glu Ala Pro Leu Gln Ala Ala Ala 
            340                 345                 350         


Leu Arg Ala Glu Arg Gly Gln Ala Lys Val Arg Val His Val Gln Asp 
        355                 360                 365             


Thr Asn Glu Pro Pro Val Phe Gln Glu Asn Pro Leu Arg Thr Ser Leu 
    370                 375                 380                 


Ala Glu Gly Ala Pro Pro Gly Thr Leu Val Ala Thr Phe Ser Ala Arg 
385                 390                 395                 400 


Asp Pro Asp Thr Glu Gln Leu Gln Arg Leu Ser Tyr Ser Lys Asp Tyr 
                405                 410                 415     


Asp Pro Glu Asp Trp Leu Gln Val Asp Ala Ala Thr Gly Arg Ile Gln 
            420                 425                 430         


Thr Gln His Val Leu Ser Pro Ala Ser Pro Phe Leu Lys Gly Gly Trp 
        435                 440                 445             


Tyr Arg Ala Ile Val Leu Ala Gln Asp Asp Ala Ser Gln Pro Arg Thr 
    450                 455                 460                 


Ala Thr Gly Thr Leu Ser Ile Glu Ile Leu Glu Val Asn Asp His Ala 
465                 470                 475                 480 


Pro Val Leu Ala Pro Pro Pro Pro Gly Ser Leu Cys Ser Glu Pro His 
                485                 490                 495     


Gln Gly Pro Gly Leu Leu Leu Gly Ala Thr Asp Glu Asp Leu Pro Pro 
            500                 505                 510         


His Gly Ala Pro Phe His Phe Gln Leu Ser Pro Arg Leu Pro Glu Leu 
        515                 520                 525             


Gly Arg Asn Trp Ser Leu Ser Gln Val Asn Val Ser His Ala Arg Leu 
    530                 535                 540                 


Arg Pro Arg His Gln Val Pro Glu Gly Leu His Arg Leu Ser Leu Leu 
545                 550                 555                 560 


Leu Arg Asp Ser Gly Gln Pro Pro Gln Gln Arg Glu Gln Pro Leu Asn 
                565                 570                 575     


Val Thr Val Cys Arg Cys Gly Lys Asp Gly Val Cys Leu Pro Gly Ala 
            580                 585                 590         


Ala Ala Leu Leu Ala Gly Gly Thr Gly Leu Ser Leu Gly Ala Leu Val 
        595                 600                 605             


Ile Val Leu Ala Ser Ala Leu Leu Leu Leu Val Leu Val Leu Leu Val 
    610                 615                 620                 


Ala Leu Arg Ala Arg Phe Trp Lys Gln Ser Arg Gly Lys Gly Leu Leu 
625                 630                 635                 640 


His Gly Pro Gln Asp Asp Leu Arg Asp Asn Val Leu Asn Tyr Asp Glu 
                645                 650                 655     


Gln Gly Gly Gly Glu Glu Asp Gln Asp Ala Tyr Asp Ile Ser Gln Leu 
            660                 665                 670         


Arg His Pro Thr Ala Leu Ser Leu Pro Leu Gly Pro Pro Pro Leu Arg 
        675                 680                 685             


Arg Asp Ala Pro Gln Gly Arg Leu His Pro Gln Pro Pro Arg Val Leu 
    690                 695                 700                 


Pro Thr Ser Pro Leu Asp Ile Ala Asp Phe Ile Asn Asp Gly Leu Glu 
705                 710                 715                 720 


Ala Ala Asp Ser Asp Pro Ser Val Pro Pro Tyr Asp Thr Ala Leu Ile 
                725                 730                 735     


Tyr Asp Tyr Glu Gly Asp Gly Ser Val Ala Gly Thr Leu Ser Ser Ile 
            740                 745                 750         


Leu Ser Ser Gln Gly Asp Glu Asp Gln Asp Tyr Asp Tyr Leu Arg Asp 
        755                 760                 765             


Trp Gly Pro Arg Phe Ala Arg Leu Ala Asp Met Tyr Gly His Pro Cys 
    770                 775                 780                 


Gly Leu Glu Tyr Gly Ala Arg Trp Asp His Gln Ala Arg Glu Gly Leu 
785                 790                 795                 800 


Ser Pro Gly Ala Leu Leu Pro Arg His Arg Gly Arg Thr Ala 
                805                 810                 


<210>  1901
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH16__Homo_sapiens__NP_001191673

<400>  1901

Met Val Pro Ala Trp Leu Trp Leu Leu Cys Val Ser Val Pro Gln Ala 
1               5                   10                  15      


Leu Pro Lys Ala Gln Pro Ala Glu Leu Ser Val Glu Val Pro Glu Asn 
            20                  25                  30          


Tyr Gly Gly Asn Phe Pro Leu Tyr Leu Thr Lys Leu Pro Leu Pro Arg 
        35                  40                  45              


Glu Gly Ala Glu Gly Gln Ile Val Leu Ser Gly Asp Ser Gly Lys Ala 
    50                  55                  60                  


Thr Glu Gly Pro Phe Ala Met Asp Pro Asp Ser Gly Phe Leu Leu Val 
65                  70                  75                  80  


Thr Arg Ala Leu Asp Arg Glu Glu Gln Ala Glu Tyr Gln Leu Gln Val 
                85                  90                  95      


Thr Leu Glu Met Gln Asp Gly His Val Leu Trp Gly Pro Gln Pro Val 
            100                 105                 110         


Leu Val His Val Lys Asp Glu Asn Asp Gln Val Pro His Phe Ser Gln 
        115                 120                 125             


Ala Ile Tyr Arg Ala Arg Leu Ser Arg Gly Thr Arg Pro Gly Ile Pro 
    130                 135                 140                 


Phe Leu Phe Leu Glu Ala Ser Asp Arg Asp Glu Pro Gly Thr Ala Asn 
145                 150                 155                 160 


Ser Asp Leu Arg Phe His Ile Leu Ser Gln Ala Pro Ala Gln Pro Ser 
                165                 170                 175     


Pro Asp Met Phe Gln Leu Glu Pro Arg Leu Gly Ala Leu Ala Leu Ser 
            180                 185                 190         


Pro Lys Gly Ser Thr Ser Leu Asp His Ala Leu Glu Arg Thr Tyr Gln 
        195                 200                 205             


Leu Leu Val Gln Val Lys Asp Met Gly Asp Gln Ala Ser Gly His Gln 
    210                 215                 220                 


Ala Thr Ala Thr Val Glu Val Ser Ile Ile Glu Ser Thr Trp Val Ser 
225                 230                 235                 240 


Leu Glu Pro Ile His Leu Ala Glu Asn Leu Lys Val Leu Tyr Pro His 
                245                 250                 255     


His Met Ala Gln Val His Trp Ser Gly Gly Asp Val His Tyr His Leu 
            260                 265                 270         


Glu Ser His Pro Pro Gly Pro Phe Glu Val Asn Ala Glu Gly Asn Leu 
        275                 280                 285             


Tyr Val Thr Arg Glu Leu Asp Arg Glu Ala Gln Ala Glu Tyr Leu Leu 
    290                 295                 300                 


Gln Val Arg Ala Gln Asn Ser His Gly Glu Asp Tyr Ala Ala Pro Leu 
305                 310                 315                 320 


Glu Leu His Val Leu Val Met Asp Glu Asn Asp Asn Val Pro Ile Cys 
                325                 330                 335     


Pro Pro Arg Asp Pro Thr Val Ser Ile Pro Glu Leu Ser Pro Pro Gly 
            340                 345                 350         


Thr Glu Val Thr Arg Leu Ser Ala Glu Asp Ala Asp Ala Pro Gly Ser 
        355                 360                 365             


Pro Asn Ser His Val Val Tyr Gln Leu Leu Ser Pro Glu Pro Glu Asp 
    370                 375                 380                 


Gly Val Glu Gly Arg Ala Phe Gln Val Asp Pro Thr Ser Gly Ser Val 
385                 390                 395                 400 


Thr Leu Gly Val Leu Pro Leu Arg Ala Gly Gln Asn Ile Leu Leu Leu 
                405                 410                 415     


Val Leu Ala Met Asp Leu Ala Gly Ala Glu Gly Gly Phe Ser Ser Thr 
            420                 425                 430         


Cys Glu Val Glu Val Ala Val Thr Asp Ile Asn Asp His Ala Pro Glu 
        435                 440                 445             


Phe Ile Thr Ser Gln Ile Gly Pro Ile Ser Leu Pro Glu Asp Val Glu 
    450                 455                 460                 


Pro Gly Thr Leu Val Ala Met Leu Thr Ala Ile Asp Ala Asp Leu Glu 
465                 470                 475                 480 


Pro Ala Phe Arg Leu Met Asp Phe Ala Ile Glu Arg Gly Asp Thr Glu 
                485                 490                 495     


Gly Thr Phe Gly Leu Asp Trp Glu Pro Asp Ser Gly His Val Arg Leu 
            500                 505                 510         


Arg Leu Cys Lys Asn Leu Ser Tyr Glu Ala Ala Pro Ser His Glu Val 
        515                 520                 525             


Val Val Val Val Gln Ser Val Ala Lys Leu Val Gly Pro Gly Pro Gly 
    530                 535                 540                 


Pro Gly Ala Thr Ala Thr Val Thr Val Leu Val Glu Arg Val Met Pro 
545                 550                 555                 560 


Pro Pro Lys Leu Asp Gln Glu Ser Tyr Glu Ala Ser Val Pro Ile Ser 
                565                 570                 575     


Ala Pro Ala Gly Ser Phe Leu Leu Thr Ile Gln Pro Ser Asp Pro Ile 
            580                 585                 590         


Ser Arg Thr Leu Arg Phe Ser Leu Val Asn Asp Ser Glu Gly Trp Leu 
        595                 600                 605             


Cys Ile Glu Lys Phe Ser Gly Glu Val His Thr Ala Gln Ser Leu Gln 
    610                 615                 620                 


Gly Ala Gln Pro Gly Asp Thr Tyr Thr Val Leu Val Glu Ala Gln Asp 
625                 630                 635                 640 


Thr Ala Leu Thr Leu Ala Pro Val Pro Ser Gln Tyr Leu Cys Thr Pro 
                645                 650                 655     


Arg Gln Asp His Gly Leu Ile Val Ser Gly Pro Ser Lys Asp Pro Asp 
            660                 665                 670         


Leu Ala Ser Gly His Gly Pro Tyr Ser Phe Thr Leu Gly Pro Asn Pro 
        675                 680                 685             


Thr Val Gln Arg Asp Trp Arg Leu Gln Thr Leu Asn Gly Ser His Ala 
    690                 695                 700                 


Tyr Leu Thr Leu Ala Leu His Trp Val Glu Pro Arg Glu His Ile Ile 
705                 710                 715                 720 


Pro Val Val Val Ser His Asn Ala Gln Met Trp Gln Leu Leu Val Arg 
                725                 730                 735     


Val Ile Val Cys Arg Cys Asn Val Glu Gly Gln Cys Met Arg Lys Val 
            740                 745                 750         


Gly Arg Met Lys Gly Met Pro Thr Lys Leu Ser Ala Val Gly Ile Leu 
        755                 760                 765             


Val Gly Thr Leu Val Ala Ile Gly Ile Phe Leu Ile Leu Ile Phe Thr 
    770                 775                 780                 


His Trp Thr Met Ser Arg Lys Lys Asp Pro Asp Gln Pro Ala Asp Ser 
785                 790                 795                 800 


Val Pro Leu Lys Ala Thr Val 
                805         


<210>  1902
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH17__Homo_sapiens__NP_001138135

<400>  1902

Met Ile Leu Gln Ala His Leu His Ser Leu Cys Leu Leu Met Leu Tyr 
1               5                   10                  15      


Leu Ala Thr Gly Tyr Gly Gln Glu Gly Lys Phe Ser Gly Pro Leu Lys 
            20                  25                  30          


Pro Met Thr Phe Ser Ile Tyr Glu Gly Gln Glu Pro Ser Gln Ile Ile 
        35                  40                  45              


Phe Gln Phe Lys Ala Asn Pro Pro Ala Val Thr Phe Glu Leu Thr Gly 
    50                  55                  60                  


Glu Thr Asp Asn Ile Phe Val Ile Glu Arg Glu Gly Leu Leu Tyr Tyr 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Arg Glu Thr Arg Ser Thr His Asn Leu Gln Val 
                85                  90                  95      


Ala Ala Leu Asp Ala Asn Gly Ile Ile Val Glu Gly Pro Val Pro Ile 
            100                 105                 110         


Thr Ile Lys Val Lys Asp Ile Asn Asp Asn Arg Pro Thr Phe Leu Gln 
        115                 120                 125             


Ser Lys Tyr Glu Gly Ser Val Arg Gln Asn Ser Arg Pro Gly Lys Pro 
    130                 135                 140                 


Phe Leu Tyr Val Asn Ala Thr Asp Leu Asp Asp Pro Ala Thr Pro Asn 
145                 150                 155                 160 


Gly Gln Leu Tyr Tyr Gln Ile Val Ile Gln Leu Pro Met Ile Asn Asn 
                165                 170                 175     


Val Met Tyr Phe Gln Ile Asn Asn Lys Thr Gly Ala Ile Ser Leu Thr 
            180                 185                 190         


Arg Glu Gly Ser Gln Glu Leu Asn Pro Ala Lys Asn Pro Ser Tyr Asn 
        195                 200                 205             


Leu Val Ile Ser Val Lys Asp Met Gly Gly Gln Ser Glu Asn Ser Phe 
    210                 215                 220                 


Ser Asp Thr Thr Ser Val Asp Ile Ile Val Thr Glu Asn Ile Trp Lys 
225                 230                 235                 240 


Ala Pro Lys Pro Val Glu Met Val Glu Asn Ser Thr Asp Pro His Pro 
                245                 250                 255     


Ile Lys Ile Thr Gln Val Arg Trp Asn Asp Pro Gly Ala Gln Tyr Ser 
            260                 265                 270         


Leu Val Asp Lys Glu Lys Leu Pro Arg Phe Pro Phe Ser Ile Asp Gln 
        275                 280                 285             


Glu Gly Asp Ile Tyr Val Thr Gln Pro Leu Asp Arg Glu Glu Lys Asp 
    290                 295                 300                 


Ala Tyr Val Phe Tyr Ala Val Ala Lys Asp Glu Tyr Gly Lys Pro Leu 
305                 310                 315                 320 


Ser Tyr Pro Leu Glu Ile His Val Lys Val Lys Asp Ile Asn Asp Asn 
                325                 330                 335     


Pro Pro Thr Cys Pro Ser Pro Val Thr Val Phe Glu Val Gln Glu Asn 
            340                 345                 350         


Glu Arg Leu Gly Asn Ser Ile Gly Thr Leu Thr Ala His Asp Arg Asp 
        355                 360                 365             


Glu Glu Asn Thr Ala Asn Ser Phe Leu Asn Tyr Arg Ile Val Glu Gln 
    370                 375                 380                 


Thr Pro Lys Leu Pro Met Asp Gly Leu Phe Leu Ile Gln Thr Tyr Ala 
385                 390                 395                 400 


Gly Met Leu Gln Leu Ala Lys Gln Ser Leu Lys Lys Gln Asp Thr Pro 
                405                 410                 415     


Gln Tyr Asn Leu Thr Ile Glu Val Ser Asp Lys Asp Phe Lys Thr Leu 
            420                 425                 430         


Cys Phe Val Gln Ile Asn Val Ile Asp Ile Asn Asp Gln Ile Pro Ile 
        435                 440                 445             


Phe Glu Lys Ser Asp Tyr Gly Asn Leu Thr Leu Ala Glu Asp Thr Asn 
    450                 455                 460                 


Ile Gly Ser Thr Ile Leu Thr Ile Gln Ala Thr Asp Ala Asp Glu Pro 
465                 470                 475                 480 


Phe Thr Gly Ser Ser Lys Ile Leu Tyr His Ile Ile Lys Gly Asp Ser 
                485                 490                 495     


Glu Gly Arg Leu Gly Val Asp Thr Asp Pro His Thr Asn Thr Gly Tyr 
            500                 505                 510         


Val Ile Ile Lys Lys Pro Leu Asp Phe Glu Thr Ala Ala Val Ser Asn 
        515                 520                 525             


Ile Val Phe Lys Ala Glu Asn Pro Glu Pro Leu Val Phe Gly Val Lys 
    530                 535                 540                 


Tyr Asn Ala Ser Ser Phe Ala Lys Phe Thr Leu Ile Val Thr Asp Val 
545                 550                 555                 560 


Asn Glu Ala Pro Gln Phe Ser Gln His Val Phe Gln Ala Lys Val Ser 
                565                 570                 575     


Glu Asp Val Ala Ile Gly Thr Lys Val Gly Asn Val Thr Ala Lys Asp 
            580                 585                 590         


Pro Glu Gly Leu Asp Ile Ser Tyr Ser Leu Arg Gly Asp Thr Arg Gly 
        595                 600                 605             


Trp Leu Lys Ile Asp His Val Thr Gly Glu Ile Phe Ser Val Ala Pro 
    610                 615                 620                 


Leu Asp Arg Glu Ala Gly Ser Pro Tyr Arg Val Gln Val Val Ala Thr 
625                 630                 635                 640 


Glu Val Gly Gly Ser Ser Leu Ser Ser Val Ser Glu Phe His Leu Ile 
                645                 650                 655     


Leu Met Asp Val Asn Asp Asn Pro Pro Arg Leu Ala Lys Asp Tyr Thr 
            660                 665                 670         


Gly Leu Phe Phe Cys His Pro Leu Ser Ala Pro Gly Ser Leu Ile Phe 
        675                 680                 685             


Glu Ala Thr Asp Asp Asp Gln His Leu Phe Arg Gly Pro His Phe Thr 
    690                 695                 700                 


Phe Ser Leu Gly Ser Gly Ser Leu Gln Asn Asp Trp Glu Val Ser Lys 
705                 710                 715                 720 


Ile Asn Gly Thr His Ala Arg Leu Ser Thr Arg His Thr Glu Phe Glu 
                725                 730                 735     


Glu Arg Glu Tyr Val Val Leu Ile Arg Ile Asn Asp Gly Gly Arg Pro 
            740                 745                 750         


Pro Leu Glu Gly Ile Val Ser Leu Pro Val Thr Phe Cys Ser Cys Val 
        755                 760                 765             


Glu Gly Ser Cys Phe Arg Pro Ala Gly His Gln Thr Gly Ile Pro Thr 
    770                 775                 780                 


Val Gly Met Ala Val Gly Ile Leu Leu Thr Thr Leu Leu Val Ile Gly 
785                 790                 795                 800 


Ile Ile Leu Ala Val Val Phe Ile Arg Ile Lys Lys Asp Lys Gly Lys 
                805                 810                 815     


Asp Asn Val Glu Ser Ala Gln Ala Ser Glu Val Lys Pro Leu Arg Ser 
            820                 825                 830         


<210>  1903
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH18__Homo_sapiens__NP_001161139

<400>  1903

Met Lys Ile Thr Ser Thr Ser Cys Ile Cys Pro Val Leu Val Cys Leu 
1               5                   10                  15      


Cys Phe Val Gln Arg Cys Tyr Gly Thr Ala His His Ser Ser Ile Lys 
            20                  25                  30          


Val Met Arg Asn Gln Thr Lys His Ile Glu Gly Glu Thr Glu Val His 
        35                  40                  45              


His Arg Pro Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu Glu 
    50                  55                  60                  


Glu His Met Gly Pro Asp Pro Gln Tyr Val Gly Lys Leu His Ser Asn 
65                  70                  75                  80  


Ser Asp Lys Gly Asp Gly Ser Val Lys Tyr Ile Leu Thr Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Ile Ile Asp Asp Thr Thr Gly Asp Ile His Ser 
            100                 105                 110         


Thr Lys Ser Leu Asp Arg Glu Gln Lys Thr His Tyr Val Leu His Ala 
        115                 120                 125             


Gln Ala Ile Asp Arg Arg Thr Asn Lys Pro Leu Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Ala Pro Lys Phe Thr 
145                 150                 155                 160 


Asp Gly Pro Tyr Ile Val Thr Val Pro Glu Met Ser Asp Met Gly Thr 
                165                 170                 175     


Ser Val Leu Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu His Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Arg Glu His Tyr Ser Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Ala Gly Gln Val Gly Gly Leu Ser Gly Ser Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Lys His 
            260                 265                 270         


Tyr Gln Leu Tyr Val Pro Glu Ser Ala Gln Val Gly Ser Ala Val Gly 
        275                 280                 285             


Lys Ile Lys Ala Asn Asp Ala Asp Thr Gly Ser Asn Ala Asp Met Thr 
    290                 295                 300                 


Tyr Ser Ile Ile Asn Gly Asp Gly Met Gly Ile Phe Ser Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Glu Thr Arg Glu Gly Ile Leu Ser Leu Lys Lys Pro Leu Asn 
                325                 330                 335     


Tyr Glu Lys Lys Lys Ser Tyr Thr Leu Asn Ile Glu Gly Ala Asn Thr 
            340                 345                 350         


His Leu Asp Phe Arg Phe Ser His Leu Gly Pro Phe Lys Asp Ala Thr 
        355                 360                 365             


Met Leu Lys Ile Ile Val Gly Asp Val Asp Glu Pro Pro Leu Phe Ser 
    370                 375                 380                 


Met Pro Ser Tyr Leu Met Glu Val Tyr Glu Asn Ala Lys Ile Gly Thr 
385                 390                 395                 400 


Val Val Gly Thr Val Leu Ala Gln Asp Pro Asp Ser Thr Asn Ser Leu 
                405                 410                 415     


Val Arg Tyr Phe Ile Asn Tyr Asn Val Glu Asp Asp Arg Phe Phe Asn 
            420                 425                 430         


Ile Asp Ala Asn Thr Gly Thr Ile Arg Thr Thr Lys Val Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Pro Trp Tyr Asn Ile Thr Val Thr Ala Ser Glu Ile Asp 
    450                 455                 460                 


Asn Pro Asp Leu Leu Ser His Val Thr Val Gly Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Pro Pro Glu Leu Ala Arg Glu Tyr Asp Ile Ile Val 
                485                 490                 495     


Cys Glu Asn Ser Lys Pro Gly Gln Val Ile His Thr Ile Ser Ala Thr 
            500                 505                 510         


Asp Lys Asp Asp Phe Ala Asn Gly Pro Arg Phe Asn Phe Phe Leu Asp 
        515                 520                 525             


Glu Arg Leu Pro Val Asn Pro Asn Phe Thr Leu Lys Asp Asn Glu Ala 
    530                 535                 540                 


Ala Ala Pro Ser Pro Ser Gly Phe Val His Ala Arg Glu Met Gly Val 
545                 550                 555                 560 


Cys Gly Pro Ala Met Gln Lys Pro Ser Cys Pro Arg Leu Val 
                565                 570                 


<210>  1904
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH19__Homo_sapiens__NP_001257957

<400>  1904

Met Asn Cys Tyr Leu Leu Leu Arg Phe Met Leu Gly Ile Pro Leu Leu 
1               5                   10                  15      


Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln Thr Lys Lys Val Lys 
            20                  25                  30          


Gln Pro Val Arg Ser His Leu Arg Val Lys Arg Gly Trp Val Trp Asn 
        35                  40                  45              


Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr Ser His His Ile Gly 
    50                  55                  60                  


Gln Leu Arg Ser Asp Leu Asp Asn Gly Asn Asn Ser Phe Gln Tyr Lys 
65                  70                  75                  80  


Leu Leu Gly Ala Gly Ala Gly Ser Thr Phe Ile Ile Asp Glu Arg Thr 
                85                  90                  95      


Gly Asp Ile Tyr Ala Ile Gln Lys Leu Asp Arg Glu Glu Arg Ser Leu 
            100                 105                 110         


Tyr Ile Leu Arg Ala Gln Val Ile Asp Ile Ala Thr Gly Arg Ala Val 
        115                 120                 125             


Glu Pro Glu Ser Glu Phe Val Ile Lys Val Ser Asp Ile Asn Asp Asn 
    130                 135                 140                 


Glu Pro Lys Phe Leu Asp Glu Pro Tyr Glu Ala Ile Val Pro Glu Met 
145                 150                 155                 160 


Ser Pro Glu Gly Thr Leu Val Ile Gln Val Thr Ala Ser Asp Ala Asp 
                165                 170                 175     


Asp Pro Ser Ser Gly Asn Asn Ala Arg Leu Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Gly Gln Pro Tyr Phe Ser Val Glu Pro Thr Thr Gly Val Ile Arg Ile 
        195                 200                 205             


Ser Ser Lys Met Asp Arg Glu Leu Gln Asp Glu Tyr Trp Val Ile Ile 
    210                 215                 220                 


Gln Ala Lys Asp Met Ile Gly Gln Pro Gly Ala Leu Ser Gly Thr Thr 
225                 230                 235                 240 


Ser Val Leu Ile Lys Leu Ser Asp Val Asn Asp Asn Lys Pro Ile Phe 
                245                 250                 255     


Lys Glu Ser Leu Tyr Arg Leu Thr Val Ser Glu Ser Ala Pro Thr Gly 
            260                 265                 270         


Thr Ser Ile Gly Thr Ile Met Ala Tyr Asp Asn Asp Ile Gly Glu Asn 
        275                 280                 285             


Ala Glu Met Asp Tyr Ser Ile Glu Glu Asp Asp Ser Gln Thr Phe Asp 
    290                 295                 300                 


Ile Ile Thr Asn His Glu Thr Gln Glu Gly Ile Val Ile Leu Lys Lys 
305                 310                 315                 320 


Lys Val Asp Phe Glu His Gln Asn His Tyr Gly Ile Arg Ala Lys Val 
                325                 330                 335     


Lys Asn His His Val Pro Glu Gln Leu Met Lys Tyr His Thr Glu Ala 
            340                 345                 350         


Ser Thr Thr Phe Ile Lys Ile Gln Val Glu Asp Val Asp Glu Pro Pro 
        355                 360                 365             


Leu Phe Leu Leu Pro Tyr Tyr Val Phe Glu Val Phe Glu Glu Thr Pro 
    370                 375                 380                 


Gln Gly Ser Phe Val Gly Val Val Ser Ala Thr Asp Pro Asp Asn Arg 
385                 390                 395                 400 


Lys Ser Pro Ile Arg Tyr Ser Ile Thr Arg Ser Lys Val Phe Asn Ile 
                405                 410                 415     


Asn Asp Asn Gly Thr Ile Thr Thr Ser Asn Ser Leu Asp Arg Glu Ile 
            420                 425                 430         


Ser Ala Trp Tyr Asn Leu Ser Ile Thr Ala Thr Glu Lys Tyr Asn Ile 
        435                 440                 445             


Glu Gln Ile Ser Ser Ile Pro Leu Tyr Val Gln Val Leu Asn Ile Asn 
    450                 455                 460                 


Asp His Ala Pro Glu Phe Ser Gln Tyr Tyr Glu Thr Tyr Val Cys Glu 
465                 470                 475                 480 


Asn Ala Gly Ser Gly Gln Gly Leu Phe Phe 
                485                 490 


<210>  1905
<211>  882
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH1__Homo_sapiens__NP_004351

<400>  1905

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  1906
<211>  801
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH20__Homo_sapiens__XP_005266739

<400>  1906

Met Trp Thr Ser Gly Arg Met Ser Asn Ala Lys Asn Trp Leu Gly Leu 
1               5                   10                  15      


Gly Met Ser Leu Tyr Phe Trp Gly Leu Met Asp Leu Thr Thr Thr Val 
            20                  25                  30          


Leu Ser Asp Thr Pro Thr Pro Gln Gly Glu Leu Glu Ala Leu Leu Ser 
        35                  40                  45              


Asp Lys Pro Gln Ser His Gln Arg Thr Lys Arg Ser Trp Val Trp Asn 
    50                  55                  60                  


Gln Phe Phe Val Leu Glu Glu Tyr Thr Gly Thr Asp Pro Leu Tyr Val 
65                  70                  75                  80  


Gly Lys Leu His Ser Asp Met Asp Arg Gly Asp Gly Ser Ile Lys Tyr 
                85                  90                  95      


Ile Leu Ser Gly Glu Gly Ala Gly Ile Val Phe Thr Ile Asp Asp Thr 
            100                 105                 110         


Thr Gly Asp Ile His Ala Ile Gln Arg Leu Asp Arg Glu Glu Arg Ala 
        115                 120                 125             


Gln Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Arg Thr Gly Arg Pro 
    130                 135                 140                 


Met Glu Pro Glu Ser Glu Phe Ile Ile Lys Ile Gln Asp Ile Asn Asp 
145                 150                 155                 160 


Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu 
                165                 170                 175     


Met Ser Pro Val Gly Thr Ser Val Ile Gln Val Thr Ala Thr Asp Ala 
            180                 185                 190         


Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu 
        195                 200                 205             


Gln Gly Gln Pro Tyr Phe Ser Val Asp Ser Lys Thr Gly Val Ile Arg 
    210                 215                 220                 


Thr Ala Leu Met Asn Met Asp Arg Glu Ala Lys Glu Tyr Tyr Glu Val 
225                 230                 235                 240 


Ile Ile Gln Ala Lys Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly 
                245                 250                 255     


Thr Thr Thr Val Asn Ile Thr Leu Ser Asp Val Asn Asp Asn Pro Pro 
            260                 265                 270         


Arg Phe Pro Gln Lys His Tyr Gln Met Ser Val Leu Glu Ser Ala Pro 
        275                 280                 285             


Ile Ser Ser Thr Val Gly Arg Val Phe Ala Lys Asp Leu Asp Glu Gly 
    290                 295                 300                 


Ile Asn Ala Glu Met Lys Tyr Thr Ile Val Asp Gly Asp Gly Ala Asp 
305                 310                 315                 320 


Ala Phe Asp Ile Ser Thr Asp Pro Asn Phe Gln Val Gly Ile Ile Thr 
                325                 330                 335     


Val Lys Lys Pro Leu Ser Phe Glu Ser Lys Lys Ser Tyr Thr Leu Lys 
            340                 345                 350         


Val Glu Gly Ala Asn Pro His Leu Glu Met Arg Phe Leu Asn Leu Gly 
        355                 360                 365             


Pro Phe Gln Asp Thr Thr Thr Val His Ile Ser Val Glu Asp Val Asp 
    370                 375                 380                 


Glu Pro Pro Val Phe Glu Pro Gly Phe Tyr Phe Val Glu Val Pro Glu 
385                 390                 395                 400 


Asp Val Ala Ile Gly Thr Thr Ile Gln Ile Ile Ser Ala Lys Asp Pro 
                405                 410                 415     


Asp Val Thr Asn Asn Ser Ile Arg Tyr Ser Ile Asp Arg Ser Ser Asp 
            420                 425                 430         


Pro Gly Arg Phe Phe Tyr Val Asp Ile Thr Thr Gly Ala Leu Met Thr 
        435                 440                 445             


Ala Arg Pro Leu Asp Arg Glu Glu Phe Ser Trp His Asn Ile Thr Val 
    450                 455                 460                 


Leu Ala Met Glu Met Asn Asn Pro Ser Gln Val Gly Ser Val Pro Val 
465                 470                 475                 480 


Thr Ile Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Arg 
                485                 490                 495     


Phe Tyr Glu Ala Phe Val Cys Glu Asn Ala Lys Ala Gly Gln Leu Ile 
            500                 505                 510         


Gln Thr Val Ser Ala Val Asp Gln Asp Asp Pro Arg Asn Gly Gln His 
        515                 520                 525             


Phe Tyr Tyr Ser Leu Ala Pro Glu Ala Ala Asn Asn Pro Asn Phe Thr 
    530                 535                 540                 


Ile Arg Asp Asn Gln Asp Asn Thr Ala Arg Ile Leu Thr Arg Arg Ser 
545                 550                 555                 560 


Gly Phe Arg Gln Gln Glu Gln Ser Val Phe His Leu Pro Ile Leu Ile 
                565                 570                 575     


Ala Asp Ser Gly Gln Pro Val Leu Ser Ser Thr Gly Thr Leu Thr Ile 
            580                 585                 590         


Gln Val Cys Ser Cys Asp Asp Asp Gly His Val Met Ser Cys Ser Pro 
        595                 600                 605             


Glu Ala Tyr Met Leu Pro Val Ser Leu Ser Arg Gly Ala Leu Ile Ala 
    610                 615                 620                 


Ile Leu Ala Cys Ile Phe Val Leu Leu Val Leu Val Leu Leu Ile Leu 
625                 630                 635                 640 


Ser Met Arg Arg His Arg Lys Gln Pro Tyr Ile Ile Asp Asp Glu Glu 
                645                 650                 655     


Asn Ile His Glu Asn Ile Val Arg Tyr Asp Asp Glu Gly Gly Gly Glu 
            660                 665                 670         


Glu Asp Thr Glu Ala Phe Asp Ile Ala Ala Met Trp Asn Pro Arg Glu 
        675                 680                 685             


Ala Gln Ala Gly Ala Ala Pro Lys Thr Arg Gln Asp Met Leu Pro Glu 
    690                 695                 700                 


Ile Glu Ser Leu Ser Arg Tyr Val Pro Gln Thr Cys Ala Val Asn Ser 
705                 710                 715                 720 


Thr Val His Ser Tyr Val Leu Ala Lys Leu Tyr Glu Ala Asp Met Asp 
                725                 730                 735     


Leu Trp Ala Pro Pro Phe Asp Ser Leu Gln Thr Tyr Met Phe Glu Gly 
            740                 745                 750         


Asp Gly Ser Val Ala Gly Ser Leu Ser Ser Leu Gln Ser Ala Thr Ser 
        755                 760                 765             


Asp Ser Glu Gln Ser Phe Asp Phe Leu Thr Asp Trp Gly Pro Arg Phe 
    770                 775                 780                 


Arg Lys Leu Ala Glu Leu Tyr Gly Ala Ser Glu Gly Pro Ala Pro Leu 
785                 790                 795                 800 


Trp 
    


<210>  1907
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH22__Homo_sapiens__XP_011527296

<400>  1907

Met Arg Pro Arg Pro Glu Gly Arg Gly Leu Arg Ala Gly Val Ala Leu 
1               5                   10                  15      


Ser Pro Ala Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Pro Thr Leu 
            20                  25                  30          


Leu Gly Arg Leu Trp Ala Ala Gly Thr Pro Ser Pro Ser Ala Pro Gly 
        35                  40                  45              


Ala Arg Gln Asp Gly Ala Leu Gly Ala Gly Arg Val Lys Arg Gly Trp 
    50                  55                  60                  


Val Trp Asn Gln Phe Phe Val Val Glu Glu Tyr Thr Gly Thr Glu Pro 
65                  70                  75                  80  


Leu Tyr Val Gly Lys Ile His Ser Asp Ser Asp Glu Gly Asp Gly Ala 
                85                  90                  95      


Ile Lys Tyr Thr Ile Ser Gly Glu Gly Ala Gly Thr Ile Phe Leu Ile 
            100                 105                 110         


Asp Glu Leu Thr Gly Asp Ile His Ala Met Glu Arg Leu Asp Arg Glu 
        115                 120                 125             


Gln Lys Thr Phe Tyr Thr Leu Arg Ala Gln Ala Arg Asp Arg Ala Thr 
    130                 135                 140                 


Asn Arg Leu Leu Glu Pro Glu Ser Glu Phe Ile Ile Lys Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Ser Glu Pro Arg Phe Leu His Gly Pro Tyr Ile Gly Ser 
                165                 170                 175     


Val Ala Glu Leu Ser Pro Thr Gly Thr Ser Val Met Gln Val Met Ala 
            180                 185                 190         


Ser Asp Ala Asp Asp Pro Thr Tyr Gly Ser Ser Ala Arg Leu Val Tyr 
        195                 200                 205             


Ser Val Leu Asp Gly Glu His His Phe Thr Val Asp Pro Lys Thr Gly 
    210                 215                 220                 


Val Ile Arg Thr Ala Val Pro Asp Leu Asp Arg Glu Ser Gln Glu Arg 
225                 230                 235                 240 


Tyr Glu Val Val Ile Gln Ala Thr Asp Met Ala Gly Gln Leu Gly Gly 
                245                 250                 255     


Leu Ser Gly Ser Thr Thr Val Thr Ile Val Val Thr Asp Val Asn Asp 
            260                 265                 270         


Asn Pro Pro Arg Phe Pro Gln Lys Met Tyr Gln Phe Ser Ile Gln Glu 
        275                 280                 285             


Ser Ala Pro Ile Gly Thr Ala Val Gly Arg Val Lys Ala Glu Asp Ser 
    290                 295                 300                 


Asp Val Gly Glu Asn Thr Asp Met Thr Tyr His Leu Lys Asp Glu Ser 
305                 310                 315                 320 


Ser Ser Gly Gly Asp Val Phe Lys Val Thr Thr Asp Ser Asp Thr Gln 
                325                 330                 335     


Glu Ala Ile Ile Val Val Gln Lys Arg Leu Asp Phe Glu Ser Gln Pro 
            340                 345                 350         


Val His Thr Val Ile Leu Glu Ala Leu Asn Lys Phe Val Asp Pro Arg 
        355                 360                 365             


Phe Ala Asp Leu Gly Thr Phe Arg Asp Gln Ala Ile Val Arg Val Ala 
    370                 375                 380                 


Val Thr Asp Val Asp Glu Pro Pro Glu Phe Arg Pro Pro Ser Gly Leu 
385                 390                 395                 400 


Leu Glu Val Gln Glu Asp Ala Gln Val Gly Ser Leu Val Gly Val Val 
                405                 410                 415     


Thr Ala Arg Asp Pro Asp Ala Ala Asn Arg Pro Val Arg Tyr Ala Ile 
            420                 425                 430         


Asp Arg Glu Ser Asp Leu Asp Gln Ile Phe Asp Ile Asp Ala Asp Thr 
        435                 440                 445             


Gly Ala Ile Val Thr Gly Lys Gly Leu Asp Arg Glu Thr Ala Gly Trp 
    450                 455                 460                 


His Asn Ile Thr Val Leu Ala Met Glu Ala Asp Asn His Ala Gln Leu 
465                 470                 475                 480 


Ser Arg Ala Ser Leu Arg Ile Arg Ile Leu Asp Val Asn Asp Asn Pro 
                485                 490                 495     


Pro Glu Leu Ala Thr Pro Tyr Glu Ala Ala Val Cys Glu Asp Ala Lys 
            500                 505                 510         


Pro Gly Gln Leu Ile Gln Thr Ile Ser Val Val Asp Arg Asp Glu Pro 
        515                 520                 525             


Gln Gly Gly His Arg Phe Tyr Phe Arg Leu Val Pro Glu Ala Pro Ser 
    530                 535                 540                 


Asn Pro His Phe Ser Leu Leu Asp Ile Gln Asp Asn Thr Ala Ala Val 
545                 550                 555                 560 


His Thr Gln His Val Gly Phe Asn Arg Gln Glu Gln Asp Val Phe Phe 
                565                 570                 575     


Leu Pro Ile Leu Val Val Asp Ser Gly Pro Pro Thr Leu Ser Ser Thr 
            580                 585                 590         


Gly Thr Leu Thr Ile Arg Ile Cys Gly Cys Asp Ser Ser Gly Thr Ile 
        595                 600                 605             


Gln Ser Cys Asn Thr Thr Ala Phe Val Met Ala Ala Ser Leu Ser Pro 
    610                 615                 620                 


Gly Ala Leu Ile Ala Leu Leu Val Cys Val Leu Ile Leu Val Val Leu 
625                 630                 635                 640 


Val Leu Leu Ile Leu Thr Leu Arg Arg His His Lys Ser His Leu Ser 
                645                 650                 655     


Ser Asp Glu Asp Glu Asp Met Arg Asp Asn Val Ile Lys Tyr Asn Asp 
            660                 665                 670         


Glu Gly Gly Gly Glu Gln Asp Thr Glu Ala Tyr Asp Met Ser Ala Leu 
        675                 680                 685             


Arg Ser Leu Tyr Asp Phe Gly Glu Leu Lys Gly Gly Asp Gly Gly Gly 
    690                 695                 700                 


Ser Ala Gly Gly Gly Ala Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser 
705                 710                 715                 720 


Pro Pro Gln Ala His Leu Pro Ser Glu Arg His Ser Leu Pro Gln Gly 
                725                 730                 735     


Pro Pro Ser Pro Glu Pro Asp Phe Ser Val Phe Arg Asp Phe Ile Ser 
            740                 745                 750         


Arg Lys Val Ala Leu Ala Asp Gly Asp Leu Ser Val Pro Pro Tyr Asp 
        755                 760                 765             


Ala Phe Gln Thr Tyr Ala Phe Glu Gly Ala Asp Ser Pro Ala Ala Ser 
    770                 775                 780                 


Leu Ser Ser Leu His Ser Gly Ser Ser Gly Ser Glu Gln Asp Phe Ala 
785                 790                 795                 800 


Tyr Leu Ser Ser Trp Gly Pro Arg Phe Arg Pro Leu Ala Ala Leu Tyr 
                805                 810                 815     


Ala Gly His Arg Gly Asp Asp Glu Ala Gln Ala Ser 
            820                 825             


<210>  1908
<211>  1381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH23__Homo_sapiens__NP_001165401

<400>  1908

Met Gly Arg His Val Ala Thr Ser Cys His Val Ala Trp Leu Leu Val 
1               5                   10                  15      


Leu Ile Ser Gly Cys Trp Gly Gln Val Asn Arg Leu Pro Phe Phe Thr 
            20                  25                  30          


Asn His Phe Phe Asp Thr Tyr Leu Leu Ile Ser Glu Asp Thr Pro Val 
        35                  40                  45              


Gly Ser Ser Val Thr Gln Leu Leu Ala Gln Asp Met Asp Asn Asp Pro 
    50                  55                  60                  


Leu Val Phe Gly Val Ser Gly Glu Glu Ala Ser Arg Phe Phe Ala Val 
65                  70                  75                  80  


Glu Pro Asp Thr Gly Val Val Trp Leu Arg Gln Pro Leu Asp Arg Glu 
                85                  90                  95      


Thr Lys Ser Glu Phe Thr Val Glu Phe Ser Val Ser Asp His Gln Gly 
            100                 105                 110         


Val Ile Thr Arg Lys Val Asn Ile Gln Val Gly Asp Val Asn Asp Asn 
        115                 120                 125             


Ala Pro Thr Phe His Asn Gln Pro Tyr Ser Val Arg Ile Pro Glu Asn 
    130                 135                 140                 


Thr Pro Val Gly Thr Pro Ile Phe Ile Val Asn Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Leu Gly Ala Gly Gly Ser Val Leu Tyr Ser Phe Gln Pro Pro Ser Gln 
                165                 170                 175     


Phe Phe Ala Ile Asp Ser Ala Arg Gly Ile Val Thr Val Ile Arg Glu 
            180                 185                 190         


Leu Asp Tyr Glu Thr Thr Gln Ala Tyr Gln Leu Thr Val Asn Ala Thr 
        195                 200                 205             


Asp Gln Asp Lys Thr Arg Pro Leu Ser Thr Leu Ala Asn Leu Ala Ile 
    210                 215                 220                 


Ile Ile Thr Asp Val Gln Asp Met Asp Pro Ile Phe Ile Asn Leu Pro 
225                 230                 235                 240 


Tyr Ser Thr Asn Ile Tyr Glu His Ser Pro Pro Gly Thr Thr Val Arg 
                245                 250                 255     


Ile Ile Thr Ala Ile Asp Gln Asp Lys Gly Arg Pro Arg Gly Ile Gly 
            260                 265                 270         


Tyr Thr Ile Val Ser Gly Asn Thr Asn Ser Ile Phe Ala Leu Asp Tyr 
        275                 280                 285             


Ile Ser Gly Val Leu Thr Leu Asn Gly Leu Leu Asp Arg Glu Asn Pro 
    290                 295                 300                 


Leu Tyr Ser His Gly Phe Ile Leu Thr Val Lys Gly Thr Glu Leu Asn 
305                 310                 315                 320 


Asp Asp Arg Thr Pro Ser Asp Ala Thr Val Thr Thr Thr Phe Asn Ile 
                325                 330                 335     


Leu Val Ile Asp Ile Asn Asp Asn Ala Pro Glu Phe Asn Ser Ser Glu 
            340                 345                 350         


Tyr Ser Val Ala Ile Thr Glu Leu Ala Gln Val Gly Phe Ala Leu Pro 
        355                 360                 365             


Leu Phe Ile Gln Val Val Asp Lys Asp Glu Asn Leu Gly Leu Asn Ser 
    370                 375                 380                 


Met Phe Glu Val Tyr Leu Val Gly Asn Asn Ser His His Phe Ile Ile 
385                 390                 395                 400 


Ser Pro Thr Ser Val Gln Gly Lys Ala Asp Ile Arg Ile Arg Val Ala 
                405                 410                 415     


Ile Pro Leu Asp Tyr Glu Thr Val Asp Arg Tyr Asp Phe Asp Leu Phe 
            420                 425                 430         


Ala Asn Glu Ser Val Pro Asp His Val Gly Tyr Ala Lys Val Lys Ile 
        435                 440                 445             


Thr Leu Ile Asn Glu Asn Asp Asn Arg Pro Ile Phe Ser Gln Pro Leu 
    450                 455                 460                 


Tyr Asn Ile Ser Leu Tyr Glu Asn Val Thr Val Gly Thr Ser Val Leu 
465                 470                 475                 480 


Thr Val Leu Ala Thr Asp Asn Asp Ala Gly Thr Phe Gly Glu Val Ser 
                485                 490                 495     


Tyr Phe Phe Ser Asp Asp Pro Asp Arg Phe Ser Leu Asp Lys Asp Thr 
            500                 505                 510         


Gly Leu Ile Met Leu Ile Ala Arg Leu Asp Tyr Glu Leu Ile Gln Arg 
        515                 520                 525             


Phe Thr Leu Thr Ile Ile Ala Arg Asp Gly Gly Gly Glu Glu Thr Thr 
    530                 535                 540                 


Gly Arg Val Arg Ile Asn Val Leu Asp Val Asn Asp Asn Val Pro Thr 
545                 550                 555                 560 


Phe Gln Lys Asp Ala Tyr Val Gly Ala Leu Arg Glu Asn Glu Pro Ser 
                565                 570                 575     


Val Thr Gln Leu Val Arg Leu Arg Ala Thr Asp Glu Asp Ser Pro Pro 
            580                 585                 590         


Asn Asn Gln Ile Thr Tyr Ser Ile Val Ser Ala Ser Ala Phe Gly Ser 
        595                 600                 605             


Tyr Phe Asp Ile Ser Leu Tyr Glu Gly Tyr Gly Val Ile Ser Val Ser 
    610                 615                 620                 


Arg Pro Leu Asp Tyr Glu Gln Ile Ser Asn Gly Leu Ile Tyr Leu Thr 
625                 630                 635                 640 


Val Met Ala Met Asp Ala Gly Asn Pro Pro Leu Asn Ser Thr Val Pro 
                645                 650                 655     


Val Thr Ile Glu Val Phe Asp Glu Asn Asp Asn Pro Pro Thr Phe Ser 
            660                 665                 670         


Lys Pro Ala Tyr Phe Val Ser Val Val Glu Asn Ile Met Ala Gly Ala 
        675                 680                 685             


Thr Val Leu Phe Leu Asn Ala Thr Asp Leu Asp Arg Ser Arg Glu Tyr 
    690                 695                 700                 


Gly Gln Glu Ser Ile Ile Tyr Ser Leu Glu Gly Ser Thr Gln Phe Arg 
705                 710                 715                 720 


Ile Asn Ala Arg Ser Gly Glu Ile Thr Thr Thr Ser Leu Leu Asp Arg 
                725                 730                 735     


Glu Thr Lys Ser Glu Tyr Ile Leu Ile Val Arg Ala Val Asp Gly Gly 
            740                 745                 750         


Val Gly His Asn Gln Lys Thr Gly Ile Ala Thr Val Asn Ile Thr Leu 
        755                 760                 765             


Leu Asp Ile Asn Asp Asn His Pro Thr Trp Lys Asp Ala Pro Tyr Tyr 
    770                 775                 780                 


Ile Asn Leu Val Glu Met Thr Pro Pro Asp Ser Asp Val Thr Thr Val 
785                 790                 795                 800 


Val Ala Val Asp Pro Asp Leu Gly Glu Asn Gly Thr Leu Val Tyr Ser 
                805                 810                 815     


Ile Gln Pro Pro Asn Lys Phe Tyr Ser Leu Asn Ser Thr Thr Gly Lys 
            820                 825                 830         


Ile Arg Thr Thr His Ala Met Leu Asp Arg Glu Asn Pro Asp Pro His 
        835                 840                 845             


Glu Ala Glu Leu Met Arg Lys Ile Val Val Ser Val Thr Asp Cys Gly 
    850                 855                 860                 


Arg Pro Pro Leu Lys Ala Thr Ser Ser Ala Thr Val Phe Val Asn Leu 
865                 870                 875                 880 


Leu Asp Leu Asn Asp Asn Asp Pro Thr Phe Gln Asn Leu Pro Phe Val 
                885                 890                 895     


Ala Glu Val Leu Glu Gly Ile Pro Ala Gly Val Ser Ile Tyr Gln Val 
            900                 905                 910         


Val Ala Ile Asp Leu Asp Glu Gly Leu Asn Gly Leu Val Ser Tyr Arg 
        915                 920                 925             


Met Pro Val Gly Met Pro Arg Met Asp Phe Leu Ile Asn Ser Ser Ser 
    930                 935                 940                 


Gly Val Val Val Thr Thr Thr Glu Leu Asp Arg Glu Arg Ile Ala Glu 
945                 950                 955                 960 


Tyr Gln Leu Arg Val Val Ala Ser Asp Ala Gly Thr Pro Thr Lys Ser 
                965                 970                 975     


Ser Thr Ser Thr Leu Thr Ile His Val Leu Asp Val Asn Asp Glu Thr 
            980                 985                 990         


Pro Thr Phe Phe Pro Ala Val Tyr  Asn Val Ser Val Ser  Glu Asp Val 
        995                 1000                 1005             


Pro Arg  Glu Phe Arg Val Val  Trp Leu Asn Cys Thr  Asp Asn Asp 
    1010                 1015                 1020             


Val Gly  Leu Asn Ala Glu Leu  Ser Tyr Phe Ile Thr  Gly Gly Asn 
    1025                 1030                 1035             


Val Asp  Gly Lys Phe Ser Val  Gly Tyr Arg Asp Ala  Val Val Arg 
    1040                 1045                 1050             


Thr Val  Val Gly Leu Asp Arg  Glu Thr Thr Ala Ala  Tyr Met Leu 
    1055                 1060                 1065             


Ile Leu  Glu Ala Ile Asp Asn  Gly Pro Val Gly Lys  Arg His Thr 
    1070                 1075                 1080             


Gly Thr  Ala Thr Val Phe Val  Thr Val Leu Asp Val  Asn Asp Asn 
    1085                 1090                 1095             


Arg Pro  Ile Phe Leu Gln Ser  Ser Tyr Glu Ala Ser  Val Pro Glu 
    1100                 1105                 1110             


Asp Ile  Pro Glu Gly His Ser  Ile Leu Gln Leu Lys  Ala Thr Asp 
    1115                 1120                 1125             


Ala Asp  Glu Gly Glu Phe Gly  Arg Val Trp Tyr Arg  Ile Leu His 
    1130                 1135                 1140             


Gly Asn  His Gly Asn Asn Phe  Arg Ile His Val Ser  Asn Gly Leu 
    1145                 1150                 1155             


Leu Met  Arg Gly Pro Arg Pro  Leu Asp Arg Glu Arg  Asn Ser Ser 
    1160                 1165                 1170             


His Val  Leu Ile Val Glu Ala  Tyr Asn His Asp Leu  Gly Pro Met 
    1175                 1180                 1185             


Arg Ser  Ser Val Arg Val Ile  Val Tyr Val Glu Asp  Ile Asn Asp 
    1190                 1195                 1200             


Glu Ala  Pro Val Phe Thr Gln  Gln Gln Tyr Ser Arg  Leu Gly Leu 
    1205                 1210                 1215             


Arg Glu  Thr Ala Gly Ile Gly  Thr Ser Val Ile Val  Val Gln Ala 
    1220                 1225                 1230             


Thr Asp  Arg Asp Ser Gly Asp  Gly Gly Leu Val Asn  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Ser  Gly Ala Glu Gly Lys  Phe Glu Ile Asp Glu  Ser Thr Gly 
    1250                 1255                 1260             


Leu Ile  Ile Thr Val Asn Tyr  Leu Asp Tyr Glu Thr  Lys Thr Ser 
    1265                 1270                 1275             


Tyr Met  Met Asn Val Ser Ala  Thr Asp Gln Ala Pro  Pro Phe Asn 
    1280                 1285                 1290             


Gln Gly  Phe Cys Ser Val Tyr  Ile Thr Leu Leu Asn  Glu Leu Asp 
    1295                 1300                 1305             


Glu Ala  Val Gln Phe Ser Asn  Ala Ser Tyr Glu Ala  Ala Ile Leu 
    1310                 1315                 1320             


Glu Asn  Leu Ala Leu Gly Thr  Glu Ile Val Arg Val  Gln Ala Tyr 
    1325                 1330                 1335             


Ser Ile  Asp Asn Leu Asn Gln  Ile Thr Tyr Arg Phe  Asn Ala Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Gln Ala Lys Ala  Leu Phe Lys Ile Asp  Ala Ile Thr 
    1355                 1360                 1365             


Val Arg  Gly Trp Gly Gln Gly  Ala Pro Phe Leu Pro  Ile 
    1370                 1375                 1380     


<210>  1909
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH26__Homo_sapiens__NP_068582

<400>  1909

Met Lys Pro Leu Ile Trp Thr Trp Ser Asp Val Glu Gly Gln Arg Pro 
1               5                   10                  15      


Ala Leu Leu Ile Cys Thr Ala Ala Ala Gly Pro Thr Gln Gly Val Lys 
            20                  25                  30          


Asp Leu Glu Glu Val Pro Pro Ser Ala Ala Ser Gln Ser Ala Gln Ala 
        35                  40                  45              


Arg Cys Ala Leu Gly Ser Trp Gly Tyr Gly Lys Pro Phe Glu Pro Arg 
    50                  55                  60                  


Ser Val Lys Asn Ile His Ser Thr Pro Ala Tyr Pro Asp Ala Thr Met 
65                  70                  75                  80  


His Arg Gln Leu Leu Ala Pro Val Glu Gly Arg Met Ala Glu Thr Leu 
                85                  90                  95      


Asn Gln Lys Leu His Val Ala Asn Val Leu Glu Asp Asp Pro Gly Tyr 
            100                 105                 110         


Leu Pro His Val Tyr Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro Ser 
        115                 120                 125             


Leu Ser Ser Leu Ala Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu Leu 
    130                 135                 140                 


Asp Ser Leu Gly Ser Lys Ala Thr Pro Phe Glu Glu Ile Tyr Ser Glu 
145                 150                 155                 160 


Ser Gly Val Pro Ser 
                165 


<210>  1910
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH2__Homo_sapiens__NP_001783

<400>  1910

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      


Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          


Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
        35                  40                  45              


Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  


Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  


Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
            100                 105                 110         


Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
        115                 120                 125             


Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
    130                 135                 140                 


Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 


Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     


Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         


Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
        195                 200                 205             


Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 


Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     


Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         


Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
        275                 280                 285             


Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 


Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
305                 310                 315                 320 


Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                325                 330                 335     


Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
            340                 345                 350         


Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
        355                 360                 365             


Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
    370                 375                 380                 


Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
385                 390                 395                 400 


Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                405                 410                 415     


Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
            420                 425                 430         


Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
        435                 440                 445             


Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
    450                 455                 460                 


Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 


Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     


Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         


Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             


Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 


Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
545                 550                 555                 560 


Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                565                 570                 575     


Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
            580                 585                 590         


Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             


Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
    610                 615                 620                 


Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 


Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                645                 650                 655     


Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         


Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
        675                 680                 685             


Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 


Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 


Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     


Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         


Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             


Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 


Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
785                 790                 795                 800 


Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     


Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         


Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
        835                 840                 845             


Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 


Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 


Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     


Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     


<210>  1911
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH3__Homo_sapiens__NP_001784

<400>  1911

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Thr Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Thr Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Thr Ile Ile Pro Thr Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Asn Leu Lys Ala Ala Asn Thr Asp 
        755                 760                 765             


Pro Thr Ala Pro Pro Tyr Asp Thr Leu Leu Val Phe Asp Tyr Glu Gly 
    770                 775                 780                 


Ser Gly Ser Asp Ala Ala Ser Leu Ser Ser Leu Thr Ser Ser Ala Ser 
785                 790                 795                 800 


Asp Gln Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Ser Arg Phe 
                805                 810                 815     


Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
            820                 825                 


<210>  1912
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH4__Homo_sapiens__NP_001239267

<400>  1912

Met Asn Gly Ser Cys Asp Phe Ile Leu Ser Ala Ser Phe Leu Pro Cys 
1               5                   10                  15      


Phe Lys Glu Val Lys Phe Ser Ser Cys Val Gly Thr Lys Gly Thr Gln 
            20                  25                  30          


Tyr Glu Thr Asn Ser Met Asp Phe Lys Val Gly Ala Asp Gly Thr Val 
        35                  40                  45              


Phe Ala Thr Arg Glu Leu Gln Val Pro Ser Glu Gln Val Ala Phe Thr 
    50                  55                  60                  


Val Thr Ala Trp Asp Ser Gln Thr Ala Glu Lys Trp Asp Ala Val Val 
65                  70                  75                  80  


Arg Leu Leu Val Ala Gln Thr Ser Ser Pro His Ser Gly His Lys Pro 
                85                  90                  95      


Gln Lys Gly Lys Lys Val Val Ala Leu Asp Pro Ser Pro Pro Pro Lys 
            100                 105                 110         


Asp Thr Leu Leu Pro Trp Pro Gln His Gln Asn Ala Asn Gly Leu Arg 
        115                 120                 125             


Arg Arg Lys Arg Asp Trp Val Ile Pro Pro Ile Asn Val Pro Glu Asn 
    130                 135                 140                 


Ser Arg Gly Pro Phe Pro Gln Gln Leu Val Arg Ile Arg Ser Asp Lys 
145                 150                 155                 160 


Asp Asn Asp Ile Pro Ile Arg Tyr Ser Ile Thr Gly Val Gly Ala Asp 
                165                 170                 175     


Gln Pro Pro Met Glu Val Phe Ser Ile Asp Ser Met Ser Gly Arg Met 
            180                 185                 190         


Tyr Val Thr Arg Pro Met Asp Arg Glu Glu His Ala Ser Tyr His Leu 
        195                 200                 205             


Arg Ala His Ala Val Asp Met Asn Gly Asn Lys Val Glu Asn Pro Ile 
    210                 215                 220                 


Asp Leu Tyr Ile Tyr Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe 
225                 230                 235                 240 


Ile Asn Gln Val Tyr Asn Gly Ser Val Asp Glu Gly Ser Lys Pro Gly 
                245                 250                 255     


Thr Tyr Val Met Thr Val Thr Ala Asn Asp Ala Asp Asp Ser Thr Thr 
            260                 265                 270         


Ala Asn Gly Met Val Arg Tyr Arg Ile Val Thr Gln Thr Pro Gln Ser 
        275                 280                 285             


Pro Ser Gln Asn Met Phe Thr Ile Asn Ser Glu Thr Gly Asp Ile Val 
    290                 295                 300                 


Thr Val Ala Ala Gly Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Val 
305                 310                 315                 320 


Ile Val Gln Ala Thr Asp Met Glu Gly Asn Leu Asn Tyr Gly Leu Ser 
                325                 330                 335     


Asn Thr Ala Thr Ala Ile Ile Thr Val Thr Asp Val Asn Asp Asn Pro 
            340                 345                 350         


Pro Glu Phe Thr Ala Ser Thr Phe Ala Gly Glu Val Pro Glu Asn Arg 
        355                 360                 365             


Val Glu Thr Val Val Ala Asn Leu Thr Val Met Asp Arg Asp Gln Pro 
    370                 375                 380                 


His Ser Pro Asn Trp Asn Ala Val Tyr Arg Ile Ile Ser Gly Asp Pro 
385                 390                 395                 400 


Ser Gly His Phe Ser Val Arg Thr Asp Pro Val Thr Asn Glu Gly Met 
                405                 410                 415     


Val Thr Val Val Lys Ala Val Asp Tyr Glu Leu Asn Arg Ala Phe Met 
            420                 425                 430         


Leu Thr Val Met Val Ser Asn Gln Ala Pro Leu Ala Ser Gly Ile Gln 
        435                 440                 445             


Met Ser Phe Gln Ser Thr Ala Gly Val Thr Ile Ser Ile Met Asp Ile 
    450                 455                 460                 


Asn Glu Ala Pro Tyr Phe Pro Ser Asn His Lys Leu Ile Arg Leu Glu 
465                 470                 475                 480 


Glu Gly Val Pro Pro Gly Thr Val Leu Thr Thr Phe Ser Ala Val Asp 
                485                 490                 495     


Pro Asp Arg Phe Met Gln Gln Ala Val Arg Tyr Ser Lys Leu Ser Asp 
            500                 505                 510         


Pro Ala Ser Trp Leu His Ile Asn Ala Thr Asn Gly Gln Ile Thr Thr 
        515                 520                 525             


Ala Ala Val Leu Asp Arg Glu Ser Leu Tyr Thr Lys Asn Asn Val Tyr 
    530                 535                 540                 


Glu Ala Thr Phe Leu Ala Ala Asp Asn Gly Ile Pro Pro Ala Ser Gly 
545                 550                 555                 560 


Thr Gly Thr Leu Gln Ile Tyr Leu Ile Asp Ile Asn Asp Asn Ala Pro 
                565                 570                 575     


Glu Leu Leu Pro Lys Glu Ala Gln Ile Cys Glu Lys Pro Asn Leu Asn 
            580                 585                 590         


Ala Ile Asn Ile Thr Ala Ala Asp Ala Asp Val Asp Pro Asn Ile Gly 
        595                 600                 605             


Pro Tyr Val Phe Glu Leu Pro Phe Val Pro Ala Ala Val Arg Lys Asn 
    610                 615                 620                 


Trp Thr Ile Thr Arg Leu Asn Gly Asp Tyr Ala Gln Leu Ser Leu Arg 
625                 630                 635                 640 


Ile Leu Tyr Leu Glu Ala Gly Met Tyr Asp Val Pro Ile Ile Val Thr 
                645                 650                 655     


Asp Ser Gly Asn Pro Pro Leu Ser Asn Thr Ser Ile Ile Lys Val Lys 
            660                 665                 670         


Val Cys Pro Cys Asp Asp Asn Gly Asp Cys Thr Thr Ile Gly Ala Val 
        675                 680                 685             


Ala Ala Ala Gly Leu Gly Thr Gly Ala Ile Val Ala Ile Leu Ile Cys 
    690                 695                 700                 


Ile Leu Ile Leu Leu Thr Met Val Leu Leu Phe Val Met Trp Met Lys 
705                 710                 715                 720 


Arg Arg Glu Lys Glu Arg His Thr Lys Gln Leu Leu Ile Asp Pro Glu 
                725                 730                 735     


Asp Asp Val Arg Asp Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly 
            740                 745                 750         


Glu Glu Asp Gln Asp Tyr Asp Leu Ser Gln Leu Gln Gln Pro Glu Ala 
        755                 760                 765             


Met Gly His Val Pro Ser Lys Ala Pro Gly Val Arg Arg Val Asp Glu 
    770                 775                 780                 


Arg Pro Val Gly Ala Glu Pro Gln Tyr Pro Ile Arg Pro Met Val Pro 
785                 790                 795                 800 


His Pro Gly Asp Ile Gly Asp Phe Ile Asn Glu Gly Leu Arg Ala Ala 
                805                 810                 815     


Asp Asn Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp 
            820                 825                 830         


Tyr Glu Gly Ser Gly Ser Thr Ala Gly Ser Val Ser Ser Leu Asn Ser 
        835                 840                 845             


Ser Ser Ser Gly Asp Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro 
    850                 855                 860                 


Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Glu Asp 
865                 870                 875                 


<210>  1913
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH5__Homo_sapiens__NP_001786

<400>  1913

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Ile Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 
        515                 520                 525             


Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


<210>  1914
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH6__Homo_sapiens__XP_011512223

<400>  1914

Met Arg Thr Tyr Arg Tyr Phe Leu Leu Leu Phe Trp Val Gly Gln Pro 
1               5                   10                  15      


Tyr Pro Thr Leu Ser Thr Pro Leu Ser Lys Arg Thr Ser Gly Phe Pro 
            20                  25                  30          


Ala Lys Lys Arg Ala Leu Glu Leu Ser Gly Asn Ser Lys Asn Glu Leu 
        35                  40                  45              


Asn Arg Ser Lys Arg Ser Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser Asp 
65                  70                  75                  80  


Gln Asp Arg Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp Gly 
                85                  90                  95      


Ala Gly Asp Leu Phe Ile Ile Asn Glu Asn Thr Gly Asp Ile Gln Ala 
            100                 105                 110         


Thr Lys Arg Leu Asp Arg Glu Glu Lys Pro Val Tyr Ile Leu Arg Ala 
        115                 120                 125             


Gln Ala Ile Asn Arg Arg Thr Gly Arg Pro Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Ile Phe Thr 
145                 150                 155                 160 


Lys Glu Val Tyr Thr Ala Thr Val Pro Glu Met Ser Asp Val Gly Thr 
                165                 170                 175     


Phe Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ser Glu Thr Gly Ile Ile Lys Thr Ala Leu Leu Asn Met 
    210                 215                 220                 


Asp Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Lys Thr Pro Glu Ser Ser Pro Pro Gly Thr Pro Ile Gly 
        275                 280                 285             


Arg Ile Lys Ala Ser Asp Ala Asp Val Gly Glu Asn Ala Glu Ile Glu 
    290                 295                 300                 


Tyr Ser Ile Thr Asp Gly Glu Gly Leu Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Gln Glu Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Leu Leu Asp 
                325                 330                 335     


Phe Glu Lys Lys Lys Val Tyr Thr Leu Lys Val Glu Ala Ser Asn Pro 
            340                 345                 350         


Tyr Val Glu Pro Arg Phe Leu Tyr Leu Gly Pro Phe Lys Asp Ser Ala 
        355                 360                 365             


Thr Val Arg Ile Val Val Glu Asp Val Asp Glu Pro Pro Val Phe Ser 
    370                 375                 380                 


Lys Leu Ala Tyr Ile Leu Gln Ile Arg Glu Asp Ala Gln Ile Asn Thr 
385                 390                 395                 400 


Thr Ile Gly Ser Val Thr Ala Gln Asp Pro Asp Ala Ala Arg Asn Pro 
                405                 410                 415     


Val Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Asn 
            420                 425                 430         


Ile Asp Ser Gly Asn Gly Ser Ile Phe Thr Ser Lys Leu Leu Asp Arg 
        435                 440                 445             


Glu Thr Leu Leu Trp His Asn Ile Thr Val Ile Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser Arg Val Pro Leu Tyr Ile Lys Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Glu Phe Ala Glu Phe Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Lys Ala Lys Ala Asp Gln Leu Ile Gln Thr Leu His Ala Val 
            500                 505                 510         


Asp Lys Asp Asp Pro Tyr Ser Gly His Gln Phe Ser Phe Ser Leu Ala 
        515                 520                 525             


Pro Glu Ala Ala Ser Gly Ser Asn Phe Thr Ile Gln Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Leu Thr Arg Lys Asn Gly Tyr Asn Arg His Glu 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro 
                565                 570                 575     


Val Gln Ser Ser Thr Gly Thr Val Thr Val Arg Val Cys Ala Cys Asp 
            580                 585                 590         


His His Gly Asn Met Gln Ser Cys His Ala Glu Ala Leu Ile His Pro 
        595                 600                 605             


Thr Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Ile Val 
    610                 615                 620                 


Ile Leu Leu Val Thr Val Val Leu Phe Ala Ala Leu Arg Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Glu Asp Ile Arg Asp Asn Ile 
                645                 650                 655     


Val Ser Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Thr Leu Arg Asn Pro Glu Ala Ile Glu Asp Asn Lys Leu 
        675                 680                 685             


Arg Arg Asp Ile Val Pro Glu Ala Leu Phe Leu Pro Arg Arg Thr Pro 
    690                 695                 700                 


Thr Ala Arg Asp Asn Thr Asp Val Arg Asp Phe Ile Asn Gln Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Thr Gly Ser Val Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Val Thr Thr Asp Ala Asp Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Val 
    770                 775                 780                 


Asp Ser Asp Lys Asp Ser 
785                 790 


<210>  1915
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH7__Homo_sapiens__NP_387450

<400>  1915

Met Lys Leu Gly Lys Val Glu Phe Cys His Phe Leu Gln Leu Ile Ala 
1               5                   10                  15      


Leu Phe Leu Cys Phe Ser Gly Met Ser Gln Ala Glu Leu Ser Arg Ser 
            20                  25                  30          


Arg Ser Lys Pro Tyr Phe Gln Ser Gly Arg Ser Arg Thr Lys Arg Ser 
        35                  40                  45              


Trp Val Trp Asn Gln Phe Phe Val Leu Glu Glu Tyr Met Gly Ser Asp 
    50                  55                  60                  


Pro Leu Tyr Val Gly Lys Leu His Ser Asp Val Asp Lys Gly Asp Gly 
65                  70                  75                  80  


Ser Ile Lys Tyr Ile Leu Ser Gly Glu Gly Ala Ser Ser Ile Phe Ile 
                85                  90                  95      


Ile Asp Glu Asn Thr Gly Asp Ile His Ala Thr Lys Arg Leu Asp Arg 
            100                 105                 110         


Glu Glu Gln Ala Tyr Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Leu 
        115                 120                 125             


Thr Asn Lys Pro Val Glu Pro Glu Ser Glu Phe Val Ile Lys Ile Gln 
    130                 135                 140                 


Asp Ile Asn Asp Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Thr Ala 
145                 150                 155                 160 


Gly Val Pro Glu Met Ser Pro Val Gly Thr Ser Val Val Gln Val Thr 
                165                 170                 175     


Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val 
            180                 185                 190         


Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe Ser Val Glu Pro Lys Thr 
        195                 200                 205             


Gly Val Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Asp 
    210                 215                 220                 


Gln Tyr Leu Leu Val Ile Gln Ala Lys Asp Met Val Gly Gln Asn Gly 
225                 230                 235                 240 


Gly Leu Ser Gly Thr Thr Ser Val Thr Val Thr Leu Thr Asp Val Asn 
                245                 250                 255     


Asp Asn Pro Pro Arg Phe Pro Arg Arg Ser Tyr Gln Tyr Asn Val Pro 
            260                 265                 270         


Glu Ser Leu Pro Val Ala Ser Val Val Ala Arg Ile Lys Ala Ala Asp 
        275                 280                 285             


Ala Asp Ile Gly Ala Asn Ala Glu Met Glu Tyr Lys Ile Val Asp Gly 
    290                 295                 300                 


Asp Gly Leu Gly Ile Phe Lys Ile Ser Val Asp Lys Glu Thr Gln Glu 
305                 310                 315                 320 


Gly Ile Ile Thr Ile Gln Lys Glu Leu Asp Phe Glu Ala Lys Thr Ser 
                325                 330                 335     


Tyr Thr Leu Arg Ile Glu Ala Ala Asn Lys Asp Ala Asp Pro Arg Phe 
            340                 345                 350         


Leu Ser Leu Gly Pro Phe Ser Asp Thr Thr Thr Val Lys Ile Ile Val 
        355                 360                 365             


Glu Asp Val Asp Glu Pro Pro Val Phe Ser Ser Pro Leu Tyr Pro Met 
    370                 375                 380                 


Glu Val Ser Glu Ala Thr Gln Val Gly Asn Ile Ile Gly Thr Val Ala 
385                 390                 395                 400 


Ala His Asp Pro Asp Ser Ser Asn Ser Pro Val Arg Tyr Ser Ile Asp 
                405                 410                 415     


Arg Asn Thr Asp Leu Glu Arg Tyr Phe Asn Ile Asp Ala Asn Ser Gly 
            420                 425                 430         


Val Ile Thr Thr Ala Lys Ser Leu Asp Arg Glu Thr Asn Ala Ile His 
        435                 440                 445             


Asn Ile Thr Val Leu Ala Met Glu Ser Gln Asn Pro Ser Gln Val Gly 
    450                 455                 460                 


Arg Gly Tyr Val Ala Ile Thr Ile Leu Asp Ile Asn Asp Asn Ala Pro 
465                 470                 475                 480 


Glu Phe Ala Met Asp Tyr Glu Thr Thr Val Cys Glu Asn Ala Gln Pro 
                485                 490                 495     


Gly Gln Val Ile Gln Lys Ile Ser Ala Val Asp Lys Asp Glu Pro Ser 
            500                 505                 510         


Asn Gly His Gln Phe Tyr Phe Ser Leu Thr Thr Asp Ala Thr Asn Asn 
        515                 520                 525             


His Asn Phe Ser Leu Lys Asp Asn Lys Asp Asn Thr Ala Ser Ile Leu 
    530                 535                 540                 


Thr Arg Arg Asn Gly Phe Arg Arg Gln Glu Gln Ser Val Tyr Tyr Leu 
545                 550                 555                 560 


Pro Ile Phe Ile Val Asp Ser Gly Ser Pro Ser Leu Ser Ser Thr Asn 
                565                 570                 575     


Thr Leu Thr Ile Arg Val Cys Asp Cys Asp Ala Asp Gly Val Ala Gln 
            580                 585                 590         


Thr Cys Asn Ala Glu Ala Tyr Val Leu Pro Ala Gly Leu Ser Thr Gly 
        595                 600                 605             


Ala Leu Ile Ala Ile Leu Ala Cys Val Leu Thr Leu Leu Val Leu Ile 
    610                 615                 620                 


Leu Leu Ile Val Thr Met Arg Arg Arg Lys Lys Glu Pro Leu Ile Phe 
625                 630                 635                 640 


Asp Glu Glu Arg Asp Ile Arg Glu Asn Ile Val Arg Tyr Asp Asp Glu 
                645                 650                 655     


Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Met Ala Ala Leu Arg 
            660                 665                 670         


Asn Leu Asn Val Ile Arg Asp Thr Lys Thr Arg Arg Asp Val Thr Pro 
        675                 680                 685             


Glu Ile Gln Phe Leu Ser Arg Pro Ala Phe Lys Ser Ile Pro Asp Asn 
    690                 695                 700                 


Val Ile Phe Arg Glu Phe Ile Trp Glu Arg Leu Lys Glu Ala Asp Val 
705                 710                 715                 720 


Asp Pro Gly Ala Pro Pro Tyr Asp Ser Leu Gln Thr Tyr Ala Phe Glu 
                725                 730                 735     


Gly Asn Gly Ser Val Ala Glu Ser Leu Ser Ser Leu Asp Ser Ile Ser 
            740                 745                 750         


Ser Asn Ser Asp Gln Asn Tyr Asp Tyr Leu Ser Asp Trp Gly Pro Arg 
        755                 760                 765             


Phe Lys Arg Leu Ala Asp Met Tyr Gly Thr Gly Gln Glu Ser Leu Tyr 
    770                 775                 780                 


Ser 
785 


<210>  1916
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH8__Homo_sapiens__NP_001787

<400>  1916

Met Pro Glu Arg Leu Ala Glu Met Leu Leu Asp Leu Trp Thr Pro Leu 
1               5                   10                  15      


Ile Ile Leu Trp Ile Thr Leu Pro Pro Cys Ile Tyr Met Ala Pro Met 
            20                  25                  30          


Asn Gln Ser Gln Val Leu Met Ser Gly Ser Pro Leu Glu Leu Asn Ser 
        35                  40                  45              


Leu Gly Glu Glu Gln Arg Ile Leu Asn Arg Ser Lys Arg Gly Trp Val 
    50                  55                  60                  


Trp Asn Gln Met Phe Val Leu Glu Glu Phe Ser Gly Pro Glu Pro Ile 
65                  70                  75                  80  


Leu Val Gly Arg Leu His Thr Asp Leu Asp Pro Gly Ser Lys Lys Ile 
                85                  90                  95      


Lys Tyr Ile Leu Ser Gly Asp Gly Ala Gly Thr Ile Phe Gln Ile Asn 
            100                 105                 110         


Asp Val Thr Gly Asp Ile His Ala Ile Lys Arg Leu Asp Arg Glu Glu 
        115                 120                 125             


Lys Ala Glu Tyr Thr Leu Thr Ala Gln Ala Val Asp Trp Glu Thr Ser 
    130                 135                 140                 


Lys Pro Leu Glu Pro Pro Ser Glu Phe Ile Ile Lys Val Gln Asp Ile 
145                 150                 155                 160 


Asn Asp Asn Ala Pro Glu Phe Leu Asn Gly Pro Tyr His Ala Thr Val 
                165                 170                 175     


Pro Glu Met Ser Ile Leu Gly Thr Ser Val Thr Asn Val Thr Ala Thr 
            180                 185                 190         


Asp Ala Asp Asp Pro Val Tyr Gly Asn Ser Ala Lys Leu Val Tyr Ser 
        195                 200                 205             


Ile Leu Glu Gly Gln Pro Tyr Phe Ser Ile Glu Pro Glu Thr Ala Ile 
    210                 215                 220                 


Ile Lys Thr Ala Leu Pro Asn Met Asp Arg Glu Ala Lys Glu Glu Tyr 
225                 230                 235                 240 


Leu Val Val Ile Gln Ala Lys Asp Met Gly Gly His Ser Gly Gly Leu 
                245                 250                 255     


Ser Gly Thr Thr Thr Leu Thr Val Thr Leu Thr Asp Val Asn Asp Asn 
            260                 265                 270         


Pro Pro Lys Phe Ala Gln Ser Leu Tyr His Phe Ser Val Pro Glu Asp 
        275                 280                 285             


Val Val Leu Gly Thr Ala Ile Gly Arg Val Lys Ala Asn Asp Gln Asp 
    290                 295                 300                 


Ile Gly Glu Asn Ala Gln Ser Ser Tyr Asp Ile Ile Asp Gly Asp Gly 
305                 310                 315                 320 


Thr Ala Leu Phe Glu Ile Thr Ser Asp Ala Gln Ala Gln Asp Gly Ile 
                325                 330                 335     


Ile Arg Leu Arg Lys Pro Leu Asp Phe Glu Thr Lys Lys Ser Tyr Thr 
            340                 345                 350         


Leu Lys Val Glu Ala Ala Asn Val His Ile Asp Pro Arg Phe Ser Gly 
        355                 360                 365             


Arg Gly Pro Phe Lys Asp Thr Ala Thr Val Lys Ile Val Val Glu Asp 
    370                 375                 380                 


Ala Asp Glu Pro Pro Val Phe Ser Ser Pro Thr Tyr Leu Leu Glu Val 
385                 390                 395                 400 


His Glu Asn Ala Ala Leu Asn Ser Val Ile Gly Gln Val Thr Ala Arg 
                405                 410                 415     


Asp Pro Asp Ile Thr Ser Ser Pro Ile Arg Phe Ser Ile Asp Arg His 
            420                 425                 430         


Thr Asp Leu Glu Arg Gln Phe Asn Ile Asn Ala Asp Asp Gly Lys Ile 
        435                 440                 445             


Thr Leu Ala Thr Pro Leu Asp Arg Glu Leu Ser Val Trp His Asn Ile 
    450                 455                 460                 


Thr Ile Ile Ala Thr Glu Ile Arg Asn His Ser Gln Ile Ser Arg Val 
465                 470                 475                 480 


Pro Val Ala Ile Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe 
                485                 490                 495     


Ala Ser Glu Tyr Glu Ala Phe Leu Cys Glu Asn Gly Lys Pro Gly Gln 
            500                 505                 510         


Val Ile Gln Thr Val Ser Ala Met Asp Lys Asp Asp Pro Lys Asn Gly 
        515                 520                 525             


His Tyr Phe Leu Tyr Ser Leu Leu Pro Glu Met Val Asn Asn Pro Asn 
    530                 535                 540                 


Phe Thr Ile Lys Lys Asn Glu Asp Asn Ser Leu Ser Ile Leu Ala Lys 
545                 550                 555                 560 


His Asn Gly Phe Asn Arg Gln Lys Gln Glu Val Tyr Leu Leu Pro Ile 
                565                 570                 575     


Ile Ile Ser Asp Ser Gly Asn Pro Pro Leu Ser Ser Thr Ser Thr Leu 
            580                 585                 590         


Thr Ile Arg Val Cys Gly Cys Ser Asn Asp Gly Val Val Gln Ser Cys 
        595                 600                 605             


Asn Val Glu Ala Tyr Val Leu Pro Ile Gly Leu Ser Met Gly Ala Leu 
    610                 615                 620                 


Ile Ala Ile Leu Ala Cys Ile Ile Leu Leu Leu Val Ile Val Val Leu 
625                 630                 635                 640 


Phe Val Thr Leu Arg Arg His Lys Asn Glu Pro Leu Ile Ile Lys Asp 
                645                 650                 655     


Asp Glu Asp Val Arg Glu Asn Ile Ile Arg Tyr Asp Asp Glu Gly Gly 
            660                 665                 670         


Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro 
        675                 680                 685             


Asp Gly Ile Asn Gly Phe Leu Pro Arg Lys Asp Ile Lys Pro Asp Leu 
    690                 695                 700                 


Gln Phe Met Pro Arg Gln Gly Leu Ala Pro Val Pro Asn Gly Val Asp 
705                 710                 715                 720 


Val Asp Glu Phe Ile Asn Val Arg Leu His Glu Ala Asp Asn Asp Pro 
                725                 730                 735     


Thr Ala Pro Pro Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg 
            740                 745                 750         


Gly Ser Val Ala Gly Ser Leu Ser Ser Leu Glu Ser Thr Thr Ser Asp 
        755                 760                 765             


Ser Asp Gln Asn Phe Asp Tyr Leu Ser Asp Trp Gly Pro Arg Phe Lys 
    770                 775                 780                 


Arg Leu Gly Glu Leu Tyr Ser Val Gly Glu Ser Asp Lys Glu Thr 
785                 790                 795                 


<210>  1917
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDH9__Homo_sapiens__XP_011512224

<400>  1917

Met Arg Thr Tyr His Tyr Ile Pro Leu Phe Ile Trp Thr Tyr Met Phe 
1               5                   10                  15      


His Thr Val Asp Thr Ile Leu Leu Gln Glu Lys Pro Asn Ser Tyr Leu 
            20                  25                  30          


Ser Ser Lys Lys Ile Ala Gly Leu Thr Lys Asp Asp Gly Lys Met Leu 
        35                  40                  45              


Arg Arg Thr Lys Arg Gly Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Thr Asp Thr Gln Tyr Val Gly Lys Leu His Thr Asp 
65                  70                  75                  80  


Gln Asp Lys Gly Asp Gly Asn Leu Lys Tyr Ile Leu Thr Gly Asp Gly 
                85                  90                  95      


Ala Gly Ser Leu Phe Val Ile Asp Glu Asn Thr Gly Asp Ile His Ala 
            100                 105                 110         


Ala Lys Lys Leu Asp Arg Glu Glu Lys Ser Leu Tyr Ile Leu Arg Ala 
        115                 120                 125             


Lys Ala Ile Asp Arg Lys Thr Gly Arg Gln Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Lys Phe Thr 
145                 150                 155                 160 


Lys Asp Leu Tyr Thr Ala Ser Val Pro Glu Met Ser Gly Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Thr Asp Ala Asp Asp Ala Asn Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Asp Pro Glu Ser Gly Ile Ile Lys Thr Ala Leu Pro Asp Met 
    210                 215                 220                 


Ser Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asn Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Asn Ser Pro Glu Ser Val Pro Leu Gly Thr His Leu Gly 
        275                 280                 285             


Arg Ile Lys Ala Asn Asp Pro Asp Val Gly Glu Asn Ala Glu Met Glu 
    290                 295                 300                 


Tyr Ser Ile Ala Glu Gly Asp Gly Ala Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Lys Asp Thr Gln Glu Gly Ile Ile Thr Val Lys Gln Asn Leu Asp 
                325                 330                 335     


Phe Glu Asn Gln Met Leu Tyr Thr Leu Arg Val Asp Ala Ser Asn Thr 
            340                 345                 350         


His Pro Asp Pro Arg Phe Leu His Leu Gly Pro Phe Lys Asp Thr Ala 
        355                 360                 365             


Val Val Lys Ile Ser Val Glu Asp Ile Asp Glu Pro Pro Val Phe Thr 
    370                 375                 380                 


Lys Val Ser Tyr Leu Ile Glu Val Asp Glu Asp Val Lys Glu Gly Ser 
385                 390                 395                 400 


Ile Ile Gly Gln Val Thr Ala Tyr Asp Pro Asp Ala Arg Asn Asn Leu 
                405                 410                 415     


Ile Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Gly 
            420                 425                 430         


Ile His Ser Glu Asn Gly Ser Ile Phe Thr Leu Lys Ala Leu Asp Arg 
        435                 440                 445             


Glu Ser Ser Pro Trp His Asn Ile Thr Val Thr Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser His Ile Pro Val Phe Ile Arg Ile Leu Asp 
465                 470                 475                 480 


Ile Asn Asp His Ala Pro Glu Phe Ala Met Tyr Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Asn Ala Lys Pro Gly Gln Leu Ile Gln Thr Val Ser Val Met 
            500                 505                 510         


Asp Lys Asp Asp Pro Pro Arg Gly His Lys Phe Phe Phe Glu Pro Val 
        515                 520                 525             


Pro Glu Phe Thr Leu Asn Pro Asn Phe Thr Ile Val Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Met Thr Arg Lys Asp Gly Tyr Ser Arg Asn Lys 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Ile Leu Ile Phe Asp Asn Asp Tyr Pro 
                565                 570                 575     


Ile Gln Ser Ser Thr Gly Thr Leu Thr Ile Arg Val Cys Ala Cys Asp 
            580                 585                 590         


Asn Gln Gly Asn Met Gln Ser Cys Thr Ala Glu Ala Leu Ile Leu Ser 
        595                 600                 605             


Ala Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Val Leu 
    610                 615                 620                 


Ile Leu Leu Ile Leu Val Val Leu Phe Ala Ala Leu Lys Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Asp Asp Val Arg Asp Asn Ile 
                645                 650                 655     


Val Thr Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Thr Leu Arg Asn Pro Glu Ala Arg Glu Asp Ser Lys Leu 
        675                 680                 685             


Arg Arg Asp Val Met Pro Glu Thr Ile Phe Gln Ile Arg Arg Thr Val 
    690                 695                 700                 


Pro Leu Trp Glu Asn Ile Asp Val Gln Asp Phe Ile His Arg Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Ala Asp Pro Ser Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Asn Asp Ser Ile Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Leu Thr Ala Asp Cys Asn Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Asp 
    770                 775                 780                 


Asp Ser Asp Arg Asp 
785                 


<210>  1918
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDHR1__Homo_sapiens__NP_001165442

<400>  1918

Met Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu 
1               5                   10                  15      


Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val 
            20                  25                  30          


Gly Ser Thr Asn Gly Asn Met Ala Leu Phe Ser Leu Pro Glu Asp Thr 
        35                  40                  45              


Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly 
    50                  55                  60                  


Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val 
65                  70                  75                  80  


Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu 
                85                  90                  95      


Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp 
            100                 105                 110         


Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala 
        115                 120                 125             


Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val 
    130                 135                 140                 


Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val 
145                 150                 155                 160 


Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn 
                165                 170                 175     


Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu 
            180                 185                 190         


Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile 
        195                 200                 205             


Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val 
    210                 215                 220                 


Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln 
225                 230                 235                 240 


Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr 
                245                 250                 255     


Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp 
            260                 265                 270         


Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly 
        275                 280                 285             


Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile 
    290                 295                 300                 


Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val 
305                 310                 315                 320 


Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr 
                325                 330                 335     


Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr 
            340                 345                 350         


Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn 
        355                 360                 365             


Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val 
    370                 375                 380                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln Leu Val 
385                 390                 395                 400 


Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu 
                405                 410                 415     


Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu 
            420                 425                 430         


Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val Glu Val Asn Thr 
        435                 440                 445             


Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp 
    450                 455                 460                 


Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg 
465                 470                 475                 480 


Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Ala 
                485                 490                 495     


Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr 
            500                 505                 510         


Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile 
        515                 520                 525             


Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr 
    530                 535                 540                 


Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala 
545                 550                 555                 560 


Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe 
                565                 570                 575     


Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys 
            580                 585                 590         


Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp 
        595                 600                 605             


Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser 
    610                 615                 620                 


His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala 
625                 630                 635                 640 


Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val 
                645                 650                 655     


Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu 
            660                 665                 670         


Lys Ile Asp Ile Thr Asp Ala Glu Val Arg Arg Leu Arg Tyr Met Lys 
        675                 680                 685             


Asn Ser Asn Phe Pro Gly Thr Thr Lys Ser Val Arg Lys Pro Lys Phe 
    690                 695                 700                 


Lys Pro Lys Lys Pro His Ser Ser Gln Gly Leu Phe Leu His Pro His 
705                 710                 715                 720 


Cys Glu Ile Ala Leu Phe Asn Leu Ser Asn Val Asn Leu Tyr Ser Arg 
                725                 730                 735     


Val Phe Gln Gly Ala Ala Gln Ala Ser 
            740                 745 


<210>  1919
<211>  1310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDHR2__Homo_sapiens__NP_001165447

<400>  1919

Met Ala Gln Leu Trp Leu Ser Cys Phe Leu Leu Pro Ala Leu Val Val 
1               5                   10                  15      


Ser Val Ala Ala Asn Val Ala Pro Lys Phe Leu Ala Asn Met Thr Ser 
            20                  25                  30          


Val Ile Leu Pro Glu Asp Leu Pro Val Gly Ala Gln Ala Phe Trp Leu 
        35                  40                  45              


Val Ala Glu Asp Gln Asp Asn Asp Pro Leu Thr Tyr Gly Met Ser Gly 
    50                  55                  60                  


Pro Asn Ala Tyr Phe Phe Ala Val Thr Pro Lys Thr Gly Glu Val Lys 
65                  70                  75                  80  


Leu Ala Ser Ala Leu Asp Tyr Glu Thr Leu Tyr Thr Phe Lys Val Thr 
                85                  90                  95      


Ile Ser Val Ser Asp Pro Tyr Ile Gln Val Gln Arg Glu Met Leu Val 
            100                 105                 110         


Ile Val Glu Asp Arg Asn Asp Asn Ala Pro Val Phe Gln Asn Thr Ala 
        115                 120                 125             


Phe Ser Thr Ser Ile Asn Glu Thr Leu Pro Val Gly Ser Val Val Phe 
    130                 135                 140                 


Ser Val Leu Ala Val Asp Lys Asp Met Gly Ser Ala Gly Met Val Val 
145                 150                 155                 160 


Tyr Ser Ile Glu Lys Val Ile Pro Ser Thr Gly Asp Ser Glu His Leu 
                165                 170                 175     


Phe Arg Ile Leu Ala Asn Gly Ser Ile Val Leu Asn Gly Ser Leu Ser 
            180                 185                 190         


Tyr Asn Asn Lys Ser Ala Phe Tyr Gln Leu Glu Leu Lys Ala Cys Asp 
        195                 200                 205             


Leu Gly Gly Met Tyr His Asn Thr Phe Thr Ile Gln Cys Ser Leu Pro 
    210                 215                 220                 


Val Phe Leu Ser Ile Ser Val Val Asp Gln Pro Asp Leu Asp Pro Gln 
225                 230                 235                 240 


Phe Val Arg Glu Phe Tyr Ser Ala Ser Val Ala Glu Asp Ala Ala Lys 
                245                 250                 255     


Gly Thr Ser Val Leu Thr Val Glu Ala Val Asp Gly Asp Lys Gly Ile 
            260                 265                 270         


Asn Asp Pro Val Ile Tyr Ser Ile Ser Tyr Ser Thr Arg Pro Gly Trp 
        275                 280                 285             


Phe Asp Ile Gly Ala Asp Gly Val Ile Arg Val Asn Gly Ser Leu Asp 
    290                 295                 300                 


Arg Glu Gln Leu Leu Glu Ala Asp Glu Glu Val Gln Leu Gln Val Thr 
305                 310                 315                 320 


Ala Thr Glu Thr His Leu Asn Ile Tyr Gly Gln Glu Ala Lys Val Ser 
                325                 330                 335     


Ile Trp Val Thr Val Arg Val Met Asp Val Asn Asp His Lys Pro Glu 
            340                 345                 350         


Phe Tyr Asn Cys Ser Leu Pro Ala Cys Thr Phe Thr Pro Glu Glu Ala 
        355                 360                 365             


Gln Val Asn Phe Thr Gly Tyr Val Asp Glu His Ala Ser Pro Arg Ile 
    370                 375                 380                 


Pro Ile Asp Asp Leu Thr Met Val Val Tyr Asp Pro Asp Lys Gly Ser 
385                 390                 395                 400 


Asn Gly Thr Phe Leu Leu Ser Leu Gly Gly Pro Asp Ala Glu Ala Phe 
                405                 410                 415     


Ser Val Ser Pro Glu Arg Ala Val Gly Ser Ala Ser Val Gln Val Leu 
            420                 425                 430         


Val Arg Val Ser Ala Leu Val Asp Tyr Glu Arg Gln Thr Ala Met Ala 
        435                 440                 445             


Val Gln Val Val Ala Thr Asp Ser Val Ser Gln Asn Phe Ser Val Ala 
    450                 455                 460                 


Met Val Thr Ile His Leu Arg Asp Ile Asn Asp His Arg Pro Thr Phe 
465                 470                 475                 480 


Pro Gln Ser Leu Tyr Val Leu Thr Val Pro Glu His Ser Ala Thr Gly 
                485                 490                 495     


Ser Val Val Thr Asp Ser Ile His Ala Thr Asp Pro Asp Thr Gly Ala 
            500                 505                 510         


Trp Gly Gln Ile Thr Tyr Ser Leu Leu Pro Gly Asn Gly Ala Asp Leu 
        515                 520                 525             


Phe Gln Val Asp Pro Val Ser Gly Thr Val Thr Val Arg Asn Gly Glu 
    530                 535                 540                 


Leu Leu Asp Arg Glu Ser Gln Ala Val Tyr Tyr Leu Thr Leu Gln Ala 
545                 550                 555                 560 


Thr Asp Gly Gly Asn Leu Ser Ser Ser Thr Thr Leu Gln Ile His Leu 
                565                 570                 575     


Leu Asp Ile Asn Asp Asn Ala Pro Val Val Ser Gly Ser Tyr Asn Ile 
            580                 585                 590         


Phe Val Gln Glu Glu Glu Gly Asn Val Ser Val Thr Ile Gln Ala His 
        595                 600                 605             


Asp Asn Asp Glu Pro Gly Thr Asn Asn Ser Arg Leu Leu Phe Asn Leu 
    610                 615                 620                 


Leu Pro Gly Pro Tyr Ser His Asn Phe Ser Leu Asp Pro Asp Thr Gly 
625                 630                 635                 640 


Leu Leu Arg Asn Leu Gly Pro Leu Asp Arg Glu Ala Ile Asp Pro Ala 
                645                 650                 655     


Leu Glu Gly Arg Ile Val Leu Thr Val Leu Val Ser Asp Cys Gly Glu 
            660                 665                 670         


Pro Val Leu Gly Thr Lys Val Asn Val Thr Ile Thr Val Glu Asp Ile 
        675                 680                 685             


Asn Asp Asn Leu Pro Ile Phe Asn Gln Ser Ser Tyr Asn Phe Thr Val 
    690                 695                 700                 


Lys Glu Glu Asp Pro Gly Val Leu Val Gly Val Val Lys Ala Trp Asp 
705                 710                 715                 720 


Ala Asp Gln Thr Glu Ala Asn Asn Arg Ile Ser Phe Ser Leu Ser Gly 
                725                 730                 735     


Ser Gly Ala Asn Tyr Phe Met Ile Arg Gly Leu Val Leu Gly Ala Gly 
            740                 745                 750         


Trp Ala Glu Gly Tyr Leu Arg Leu Pro Pro Asp Val Ser Leu Asp Tyr 
        755                 760                 765             


Glu Thr Gln Pro Val Phe Asn Leu Thr Val Ser Ala Glu Asn Pro Asp 
    770                 775                 780                 


Pro Gln Gly Gly Glu Thr Ile Val Asp Val Cys Val Asn Val Lys Asp 
785                 790                 795                 800 


Val Asn Asp Asn Pro Pro Thr Leu Asp Val Ala Ser Leu Arg Gly Ile 
                805                 810                 815     


Arg Val Ala Glu Asn Gly Ser Gln His Gly Gln Val Ala Val Val Val 
            820                 825                 830         


Ala Ser Asp Val Asp Thr Ser Ala Gln Leu Glu Ile Gln Leu Val Asn 
        835                 840                 845             


Ile Leu Cys Thr Lys Ala Gly Val Asp Val Gly Ser Leu Cys Trp Gly 
    850                 855                 860                 


Trp Phe Ser Val Ala Ala Asn Gly Ser Val Tyr Ile Asn Gln Ser Lys 
865                 870                 875                 880 


Ala Ile Asp Tyr Glu Ala Cys Asp Leu Val Thr Leu Val Val Arg Ala 
                885                 890                 895     


Cys Asp Leu Ala Thr Asp Pro Gly Phe Gln Ala Tyr Ser Asn Asn Gly 
            900                 905                 910         


Ser Leu Leu Ile Thr Ile Glu Asp Val Asn Asp Asn Ala Pro Tyr Phe 
        915                 920                 925             


Leu Pro Glu Asn Lys Thr Phe Val Ile Ile Pro Glu Leu Val Leu Pro 
    930                 935                 940                 


Asn Arg Glu Val Ala Ser Val Arg Ala Arg Asp Asp Asp Ser Gly Asn 
945                 950                 955                 960 


Asn Gly Val Ile Leu Phe Ser Ile Leu Arg Val Asp Phe Ile Ser Lys 
                965                 970                 975     


Asp Gly Ala Thr Ile Pro Phe Gln Gly Val Phe Ser Ile Phe Thr Ser 
            980                 985                 990         


Ser Glu Ala Asp Val Phe Ala Gly  Ser Ile Gln Pro Val  Thr Ser Leu 
        995                 1000                 1005             


Asp Ser  Thr Leu Gln Gly Thr  Tyr Gln Val Thr Val  Gln Ala Arg 
    1010                 1015                 1020             


Asp Arg  Pro Ser Leu Gly Pro  Phe Leu Glu Ala Thr  Thr Thr Leu 
    1025                 1030                 1035             


Asn Leu  Phe Thr Val Asp Gln  Ser Tyr Arg Ser Arg  Leu Gln Phe 
    1040                 1045                 1050             


Ser Thr  Pro Lys Glu Glu Val  Gly Ala Asn Arg Gln  Ala Ile Asn 
    1055                 1060                 1065             


Ala Ala  Leu Thr Gln Ala Thr  Arg Thr Thr Val Tyr  Ile Val Asp 
    1070                 1075                 1080             


Ile Gln  Asp Ile Asp Ser Ala  Ala Arg Ala Arg Pro  His Ser Tyr 
    1085                 1090                 1095             


Leu Asp  Ala Tyr Phe Val Phe  Pro Asn Gly Ser Ala  Leu Thr Leu 
    1100                 1105                 1110             


Asp Glu  Leu Ser Val Met Ile  Arg Asn Asp Gln Asp  Ser Leu Thr 
    1115                 1120                 1125             


Gln Leu  Leu Gln Leu Gly Leu  Val Val Leu Gly Ser  Gln Glu Ser 
    1130                 1135                 1140             


Gln Glu  Ser Asp Leu Ser Lys  Gln Leu Ile Ser Val  Ile Ile Gly 
    1145                 1150                 1155             


Leu Gly  Val Ala Leu Leu Leu  Val Leu Val Ile Met  Thr Met Ala 
    1160                 1165                 1170             


Phe Val  Cys Val Arg Lys Ser  Tyr Asn Arg Lys Leu  Gln Ala Met 
    1175                 1180                 1185             


Lys Ala  Ala Lys Glu Ala Arg  Lys Thr Ala Ala Gly  Val Met Pro 
    1190                 1195                 1200             


Ser Ala  Pro Ala Ile Pro Gly  Thr Asn Met Tyr Asn  Thr Glu Arg 
    1205                 1210                 1215             


Ala Asn  Pro Met Leu Asn Leu  Pro Asn Lys Asp Leu  Gly Leu Glu 
    1220                 1225                 1230             


Tyr Leu  Ser Pro Ser Asn Asp  Leu Asp Ser Val Ser  Val Asn Ser 
    1235                 1240                 1245             


Leu Asp  Asp Asn Ser Val Asp  Val Asp Lys Asn Ser  Gln Glu Ile 
    1250                 1255                 1260             


Lys Glu  His Arg Pro Pro His  Thr Pro Pro Glu Pro  Asp Pro Glu 
    1265                 1270                 1275             


Pro Leu  Ser Val Val Leu Leu  Gly Arg Gln Ala Gly  Ala Ser Gly 
    1280                 1285                 1290             


Gln Leu  Glu Gly Pro Ser Tyr  Thr Asn Ala Gly Leu  Asp Thr Thr 
    1295                 1300                 1305             


Asp Leu  
    1310 


<210>  1920
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDHR3__Homo_sapiens__NP_689963

<400>  1920

Met Gln Glu Ala Ile Ile Leu Leu Ala Leu Leu Gly Ala Met Ser Gly 
1               5                   10                  15      


Gly Glu Ala Leu His Leu Ile Leu Leu Pro Ala Thr Gly Asn Val Ala 
            20                  25                  30          


Glu Asn Ser Pro Pro Gly Thr Ser Val His Lys Phe Ser Val Lys Leu 
        35                  40                  45              


Ser Ala Ser Leu Ser Pro Val Ile Pro Gly Phe Pro Gln Ile Val Asn 
    50                  55                  60                  


Ser Asn Pro Leu Thr Glu Ala Phe Arg Val Asn Trp Leu Ser Gly Thr 
65                  70                  75                  80  


Tyr Phe Glu Val Val Thr Thr Gly Met Glu Gln Leu Asp Phe Glu Thr 
                85                  90                  95      


Gly Pro Asn Ile Phe Asp Leu Gln Ile Tyr Val Lys Asp Glu Val Gly 
            100                 105                 110         


Val Thr Asp Leu Gln Val Leu Thr Val Gln Val Thr Asp Val Asn Glu 
        115                 120                 125             


Pro Pro Gln Phe Gln Gly Asn Leu Ala Glu Gly Leu His Leu Tyr Ile 
    130                 135                 140                 


Val Glu Arg Ala Asn Pro Gly Phe Ile Tyr Gln Val Glu Ala Phe Asp 
145                 150                 155                 160 


Pro Glu Asp Thr Ser Arg Asn Ile Pro Leu Ser Tyr Phe Leu Ile Ser 
                165                 170                 175     


Pro Pro Lys Ser Phe Arg Met Ser Ala Asn Gly Thr Leu Phe Ser Thr 
            180                 185                 190         


Thr Glu Leu Asp Phe Glu Ala Gly His Arg Ser Phe His Leu Ile Val 
        195                 200                 205             


Glu Val Arg Asp Ser Gly Gly Leu Lys Ala Ser Thr Glu Leu Gln Val 
    210                 215                 220                 


Asn Ile Val Asn Leu Asn Asp Glu Val Pro Arg Phe Thr Ser Pro Thr 
225                 230                 235                 240 


Arg Val Tyr Thr Val Leu Glu Glu Leu Ser Pro Gly Thr Ile Val Ala 
                245                 250                 255     


Asn Ile Thr Ala Glu Asp Pro Asp Asp Glu Gly Phe Pro Ser His Leu 
            260                 265                 270         


Leu Tyr Ser Ile Thr Thr Val Ser Lys Tyr Phe Met Ile Asn Gln Leu 
        275                 280                 285             


Thr Gly Thr Ile Gln Val Ala Gln Arg Ile Asp Arg Asp Ala Gly Glu 
    290                 295                 300                 


Leu Arg Gln Asn Pro Thr Ile Ser Leu Glu Val Leu Val Lys Asp Arg 
305                 310                 315                 320 


Pro Tyr Gly Gly Gln Glu Asn Arg Ile Gln Ile Thr Phe Ile Val Glu 
                325                 330                 335     


Asp Val Asn Asp Asn Pro Ala Thr Cys Gln Lys Phe Thr Phe Ser Ile 
            340                 345                 350         


Met Val Pro Glu Arg Thr Ala Lys Gly Thr Leu Leu Leu Asp Leu Asn 
        355                 360                 365             


Lys Phe Cys Phe Asp Asp Asp Ser Glu Ala Pro Asn Asn Arg Phe Asn 
    370                 375                 380                 


Phe Thr Met Pro Ser Gly Val Gly Ser Gly Ser Arg Phe Leu Gln Asp 
385                 390                 395                 400 


Pro Ala Gly Ser Gly Lys Ile Val Leu Ile Gly Asp Leu Asp Tyr Glu 
                405                 410                 415     


Asn Pro Ser Asn Leu Ala Ala Gly Asn Lys Tyr Thr Val Ile Ile Gln 
            420                 425                 430         


Val Gln Asp Val Ala Pro Pro Tyr Tyr Lys Asn Asn Val Tyr Val Tyr 
        435                 440                 445             


Ile Leu Thr Ser Pro Glu Asn Glu Phe Pro Leu Ile Phe Asp Arg Pro 
    450                 455                 460                 


Ser Tyr Val Phe Asp Val Ser Glu Arg Arg Pro Ala Arg Thr Arg Val 
465                 470                 475                 480 


Gly Gln Val Arg Ala Thr Asp Lys Asp Leu Pro Gln Ser Ser Leu Leu 
                485                 490                 495     


Tyr Ser Ile Ser Thr Gly Gly Ala Ser Leu Gln Tyr Pro Asn Val Phe 
            500                 505                 510         


Trp Ile Asn Pro Lys Thr Gly Glu Leu Gln Leu Val Thr Lys Val Asp 
        515                 520                 525             


Cys Glu Thr Thr Pro Ile Tyr Ile Leu Arg Ile Gln Ala Thr Asn Asn 
    530                 535                 540                 


Glu Asp Thr Ser Ser Val Thr Val Thr Val Asn Ile Leu Glu Glu Asn 
545                 550                 555                 560 


Asp Glu Lys Pro Ile Cys Thr Pro Asn Ser Tyr Phe Leu Ala Leu Pro 
                565                 570                 575     


Val Asp Leu Lys Val Gly Thr Asn Ile Gln Asn Phe Lys Leu Thr Cys 
            580                 585                 590         


Thr Asp Leu Asp Ser Ser Pro Arg Ser Phe Arg Tyr Ser Ile Gly Pro 
        595                 600                 605             


Gly Asn Val Asn Asn His Phe Thr Phe Ser Pro Asn Ala Gly Ser Asn 
    610                 615                 620                 


Val Thr Arg Leu Leu Leu Thr Ser Arg Phe Asp Tyr Ala Gly Gly Phe 
625                 630                 635                 640 


Asp Lys Ile Trp Asp Tyr Lys Leu Leu Val Tyr Val Thr Asp Asp Asn 
                645                 650                 655     


Leu Met Ser Asp Arg Lys Lys Ala Glu Ala Leu Val Glu Thr Gly Thr 
            660                 665                 670         


Val Thr Leu Ser Ile Lys Val Ile Pro His Pro Thr Thr Ile Ile Thr 
        675                 680                 685             


Thr Thr Pro Arg Pro Arg Val Thr Tyr Gln Val Leu Arg Lys Asn Val 
    690                 695                 700                 


Tyr Ser Pro Ser Ala Trp Tyr Val Pro Phe Val Ile Thr Leu Gly Ser 
705                 710                 715                 720 


Ile Leu Leu Leu Gly Leu Leu Val Tyr Leu Val Val Leu Leu Ala Lys 
                725                 730                 735     


Ala Ile His Arg His Cys Pro Cys Lys Thr Gly Lys Asn Lys Glu Pro 
            740                 745                 750         


Leu Thr Lys Lys Gly Glu Thr Lys Thr Ala Glu Arg Asp Val Val Val 
        755                 760                 765             


Glu Thr Ile Gln Met Asn Thr Ile Phe Asp Gly Glu Ala Ile Asp Pro 
    770                 775                 780                 


Val Thr Gly Glu Thr Tyr Glu Phe Asn Ser Lys Thr Gly Ala Arg Lys 
785                 790                 795                 800 


Trp Lys Asp Pro Leu Thr Gln Met Pro Lys Trp Lys Glu Ser Ser His 
                805                 810                 815     


Gln Gly Ala Ala Pro Arg Arg Val Thr Ala Gly Glu Gly Met Gly Ser 
            820                 825                 830         


Leu Arg Ser Ala Asn Trp Glu Glu Asp Glu Leu Ser Gly Lys Ala Trp 
        835                 840                 845             


Ala Glu Asp Ala Gly Leu Gly Ser Arg Asn Glu Gly Gly Lys Leu Gly 
    850                 855                 860                 


Asn Pro Lys Asn Arg Asn Pro Ala Phe Met Asn Arg Ala Tyr Pro Lys 
865                 870                 875                 880 


Pro His Pro Gly Lys 
                885 


<210>  1921
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDHR5__Homo_sapiens__NP_001165439

<400>  1921

Met Gly Ser Trp Ala Leu Leu Trp Pro Pro Leu Leu Phe Thr Gly Leu 
1               5                   10                  15      


Leu Val Arg Pro Pro Gly Thr Met Ala Gln Ala Gln Tyr Cys Ser Val 
            20                  25                  30          


Asn Lys Asp Ile Phe Glu Val Glu Glu Asn Thr Asn Val Thr Glu Pro 
        35                  40                  45              


Leu Val Asp Ile His Val Pro Glu Gly Gln Glu Val Thr Leu Gly Ala 
    50                  55                  60                  


Leu Ser Thr Pro Phe Ala Phe Arg Ile Gln Gly Asn Gln Leu Phe Leu 
65                  70                  75                  80  


Asn Val Thr Pro Asp Tyr Glu Glu Lys Ser Leu Leu Glu Ala Gln Leu 
                85                  90                  95      


Leu Cys Gln Ser Gly Gly Thr Leu Val Thr Gln Leu Arg Val Phe Val 
            100                 105                 110         


Ser Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Phe Lys Thr 
        115                 120                 125             


Lys Glu Ile Arg Val Glu Glu Asp Thr Lys Val Asn Ser Thr Val Ile 
    130                 135                 140                 


Pro Glu Thr Gln Leu Gln Ala Glu Asp Arg Asp Lys Asp Asp Ile Leu 
145                 150                 155                 160 


Phe Tyr Thr Leu Gln Glu Met Thr Ala Gly Ala Ser Asp Tyr Phe Ser 
                165                 170                 175     


Leu Val Ser Val Asn Arg Pro Ala Leu Arg Leu Asp Arg Pro Leu Asp 
            180                 185                 190         


Phe Tyr Glu Arg Pro Asn Met Thr Phe Trp Leu Leu Val Arg Asp Thr 
        195                 200                 205             


Pro Gly Glu Asn Val Glu Pro Ser His Thr Ala Thr Ala Thr Leu Val 
    210                 215                 220                 


Leu Asn Val Val Pro Ala Asp Leu Arg Pro Pro Trp Phe Leu Pro Cys 
225                 230                 235                 240 


Thr Phe Ser Asp Gly Tyr Val Cys Ile Gln Ala Gln Tyr His Gly Ala 
                245                 250                 255     


Val Pro Thr Gly His Ile Leu Pro Ser Pro Leu Val Leu Arg Pro Gly 
            260                 265                 270         


Pro Ile Tyr Ala Glu Asp Gly Asp Arg Gly Ile Asn Gln Pro Ile Ile 
        275                 280                 285             


Tyr Ser Ile Phe Arg Gly Asn Val Asn Gly Thr Phe Ile Ile His Pro 
    290                 295                 300                 


Asp Ser Gly Asn Leu Thr Val Ala Arg Ser Val Pro Ser Pro Met Thr 
305                 310                 315                 320 


Phe Leu Leu Leu Val Lys Gly Gln Gln Ala Asp Leu Ala Arg Tyr Ser 
                325                 330                 335     


Val Thr Gln Val Thr Val Glu Ala Val Ala Ala Ala Gly Ser Pro Pro 
            340                 345                 350         


Arg Phe Pro Gln Arg Leu Tyr Arg Gly Thr Val Ala Arg Gly Ala Gly 
        355                 360                 365             


Ala Gly Val Val Val Lys Asp Ala Ala Ala Pro Ser Gln Pro Leu Arg 
    370                 375                 380                 


Ile Gln Ala Gln Asp Pro Glu Phe Ser Asp Leu Asn Ser Ala Ile Thr 
385                 390                 395                 400 


Tyr Arg Ile Thr Asn His Ser His Phe Arg Met Glu Gly Glu Val Val 
                405                 410                 415     


Leu Thr Thr Thr Thr Leu Ala Gln Ala Gly Ala Phe Tyr Ala Glu Val 
            420                 425                 430         


Glu Ala His Asn Thr Val Thr Ser Gly Thr Ala Thr Thr Val Ile Glu 
        435                 440                 445             


Ile Gln Val Ser Glu Gln Glu Pro Pro Ser Thr Glu Ala Gly Gly Thr 
    450                 455                 460                 


Thr Gly Pro Trp Thr Ser Thr Thr Ser Glu Val Pro Arg Pro Pro Glu 
465                 470                 475                 480 


Pro Ser Gln Gly Pro Ser Thr Thr Ser Ser Gly Gly Gly Thr Gly Pro 
                485                 490                 495     


His Pro Pro Ser Gly Thr Thr Leu Arg Pro Pro Thr Ser Ser Thr Pro 
            500                 505                 510         


Gly Gly Pro Pro Gly Ala Glu Asn Ser Thr Ser His Gln Pro Ala Thr 
        515                 520                 525             


Pro Gly Gly Asp Thr Ala Gln Thr Pro Lys Pro Gly Thr Ser Gln Pro 
    530                 535                 540                 


Met Pro Pro Gly Val Gly Thr Ser Thr Ser His Gln Pro Ala Thr Pro 
545                 550                 555                 560 


Ser Gly Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr Ser Gln Pro Met 
                565                 570                 575     


Pro Pro Ser Met Gly Thr Ser Thr Ser His Gln Pro Ala Thr Pro Gly 
            580                 585                 590         


Gly Gly Thr Ala Gln Thr Pro Glu Ala Gly Thr Ser Gln Pro Met Pro 
        595                 600                 605             


Pro Gly Met Gly Thr Ser Thr Ser His Gln Pro Thr Thr Pro Gly Gly 
    610                 615                 620                 


Gly Thr Ala Gln Thr Pro Glu Pro Gly Thr Ser Gln Pro Met Pro Leu 
625                 630                 635                 640 


Ser Lys Ser Thr Pro Ser Ser Gly Gly Gly Pro Ser Glu Asp Lys Arg 
                645                 650                 655     


Phe Ser Val Val Asp Met Ala Ala Leu Gly Gly Val Leu Gly Ala Leu 
            660                 665                 670         


Leu Leu Leu Ala Leu Leu Gly Leu Ala Val Leu Val His Lys His Tyr 
        675                 680                 685             


Gly Pro Arg Leu Lys Cys Cys Ser Gly Lys Ala Pro Glu Pro Gln Pro 
    690                 695                 700                 


Gln Gly Phe Asp Asn Gln Ala Phe Leu Pro Asp His Lys Ala Asn Trp 
705                 710                 715                 720 


Ala Pro Val Pro Ser Pro Thr His Asp Pro Lys Pro Ala Glu Ala Pro 
                725                 730                 735     


Met Pro Ala Glu Pro Ala Pro Pro Gly Pro Ala Ser Pro Gly Gly Ala 
            740                 745                 750         


Pro Glu Pro Pro Ala Ala Ala Arg Ala Gly Gly Ser Pro Thr Ala Val 
        755                 760                 765             


Arg Ser Ile Leu Thr Lys Glu Arg Arg Pro Glu Gly Gly Tyr Lys Ala 
    770                 775                 780                 


Val Trp Phe Gly Glu Asp Ile Gly Thr Glu Ala Asp Val Val Val Leu 
785                 790                 795                 800 


Asn Ala Pro Thr Leu Asp Val Asp Gly Ala Ser Asp Ser Gly Ser Gly 
                805                 810                 815     


Asp Glu Gly Glu Gly Ala Gly Arg Gly Gly Gly Pro Tyr Asp Ala Pro 
            820                 825                 830         


Gly Gly Asp Asp Ser Tyr Ile 
        835                 


<210>  1922
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDIPT__Homo_sapiens__NP_006310

<400>  1922

Met Pro Asp Glu Asn Ile Phe Leu Phe Val Pro Asn Leu Ile Gly Tyr 
1               5                   10                  15      


Ala Arg Ile Val Phe Ala Ile Ile Ser Phe Tyr Phe Met Pro Cys Cys 
            20                  25                  30          


Pro Leu Thr Ala Ser Ser Phe Tyr Leu Leu Ser Gly Leu Leu Asp Ala 
        35                  40                  45              


Phe Asp Gly His Ala Ala Arg Ala Leu Asn Gln Gly Thr Arg Phe Gly 
    50                  55                  60                  


Ala Met Leu Asp Met Leu Thr Asp Arg Cys Ser Thr Met Cys Leu Leu 
65                  70                  75                  80  


Val Asn Leu Ala Leu Leu Tyr Pro Gly Ala Thr Leu Phe Phe Gln Ile 
                85                  90                  95      


Ser Met Ser Leu Asp Val Ala Ser His Trp Leu His Leu His Ser Ser 
            100                 105                 110         


Val Val Arg Gly Ser Glu Ser His Lys Met Ile Asp Leu Ser Gly Asn 
        115                 120                 125             


Pro Val Leu Arg Ile Tyr Tyr Thr Ser Arg Pro Ala Leu Phe Thr Leu 
    130                 135                 140                 


Cys Ala Gly Asn Glu Leu Phe Tyr Cys Leu Leu Tyr Leu Phe His Phe 
145                 150                 155                 160 


Ser Glu Gly Pro Leu Val Gly Ser Val Gly Leu Phe Arg Met Gly Leu 
                165                 170                 175     


Trp Val Thr Ala Pro Ile Ala Leu Leu Lys Ser Leu Ile Ser Val Ile 
            180                 185                 190         


His Leu Ile Thr Ala Ala Arg Asn Met Ala Ala Leu Asp Ala Ala Asp 
        195                 200                 205             


Arg Ala Lys Lys Lys 
    210             


<210>  1923
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK10__Homo_sapiens__NP_443713

<400>  1923

Met Asp Lys Glu Lys Asp Gly Ile Pro Ile Ser Ser Leu Arg Glu Ile 
1               5                   10                  15      


Thr Leu Leu Leu Arg Leu Arg His Pro Asn Ile Val Glu Leu Lys Glu 
            20                  25                  30          


Val Val Val Gly Asn His Leu Glu Ser Ile Phe Leu Val Met Gly Tyr 
        35                  40                  45              


Cys Glu Gln Asp Leu Ala Ser Leu Leu Glu Asn Met Pro Thr Pro Phe 
    50                  55                  60                  


Ser Glu Ala Gln Val Lys Cys Ile Val Leu Gln Val Leu Arg Gly Leu 
65                  70                  75                  80  


Gln Tyr Leu His Arg Asn Phe Ile Ile His Arg Asp Leu Lys Val Ser 
                85                  90                  95      


Asn Leu Leu Met Thr Asp Lys Gly Cys Val Lys Thr Ala Asp Phe Gly 
            100                 105                 110         


Leu Ala Arg Ala Tyr Gly Val Pro Val Lys Pro Met Thr Pro Lys Val 
        115                 120                 125             


Val Thr Leu Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly Thr Thr Thr 
    130                 135                 140                 


Gln Thr Thr Ser Ile Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu 
145                 150                 155                 160 


Leu Leu Ala His Arg Pro Leu Leu Pro Gly Thr Ser Glu Ile His Gln 
                165                 170                 175     


Ile Asp Leu Ile Val Gln Leu Leu Gly Thr Pro Ser Glu Asn Ile Trp 
            180                 185                 190         


Pro Gly Phe Ser Lys Leu Pro Leu Val Gly Gln Tyr Ser Leu Arg Lys 
        195                 200                 205             


Gln Pro Tyr Asn Asn Leu Lys His Lys Phe Pro Trp Leu Ser Glu Ala 
    210                 215                 220                 


Gly Leu Arg Leu Leu His Phe Leu Phe Met Tyr Asp Pro Lys Lys Arg 
225                 230                 235                 240 


Ala Thr Ala Gly Asp Cys Leu Glu Ser Ser Tyr Phe Lys Glu Lys Pro 
                245                 250                 255     


Leu Arg Leu Pro Ile Ser Gly Val Cys Glu Gly Cys Arg Glu Pro Gly 
            260                 265                 270         


<210>  1924
<211>  795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK11B__Homo_sapiens__NP_001778

<400>  1924

Met Gly Asp Glu Lys Asp Ser Trp Lys Val Lys Thr Leu Asp Glu Ile 
1               5                   10                  15      


Leu Gln Glu Lys Lys Arg Arg Lys Glu Gln Glu Glu Lys Ala Glu Ile 
            20                  25                  30          


Lys Arg Leu Lys Asn Ser Asp Asp Arg Asp Ser Lys Arg Asp Ser Leu 
        35                  40                  45              


Glu Glu Gly Glu Leu Arg Asp His Arg Met Glu Ile Thr Ile Arg Asn 
    50                  55                  60                  


Ser Pro Tyr Arg Arg Glu Asp Ser Met Glu Asp Arg Gly Glu Glu Asp 
65                  70                  75                  80  


Asp Ser Leu Ala Ile Lys Pro Pro Gln Gln Met Ser Arg Lys Glu Lys 
                85                  90                  95      


Ala His His Arg Lys Asp Glu Lys Arg Lys Glu Lys Arg Arg His Arg 
            100                 105                 110         


Ser His Ser Ala Glu Gly Gly Lys His Ala Arg Val Lys Glu Lys Glu 
        115                 120                 125             


Arg Glu His Glu Arg Arg Lys Arg His Arg Glu Glu Gln Asp Lys Ala 
    130                 135                 140                 


Arg Arg Glu Trp Glu Arg Gln Lys Arg Arg Glu Met Ala Arg Glu His 
145                 150                 155                 160 


Ser Arg Arg Glu Arg Asp Arg Leu Glu Gln Leu Glu Arg Lys Arg Glu 
                165                 170                 175     


Arg Glu Arg Lys Met Arg Glu Gln Gln Lys Glu Gln Arg Glu Gln Lys 
            180                 185                 190         


Glu Arg Glu Arg Arg Ala Glu Glu Arg Arg Lys Glu Arg Glu Ala Arg 
        195                 200                 205             


Arg Glu Val Ser Ala His His Arg Thr Met Arg Glu Asp Tyr Ser Asp 
    210                 215                 220                 


Lys Val Lys Ala Ser His Trp Ser Arg Ser Pro Pro Arg Pro Pro Arg 
225                 230                 235                 240 


Glu Arg Phe Glu Leu Gly Asp Gly Arg Lys Pro Gly Glu Ala Arg Pro 
                245                 250                 255     


Ala Pro Ala Gln Lys Pro Ala Gln Leu Lys Glu Glu Lys Met Glu Glu 
            260                 265                 270         


Arg Asp Leu Leu Ser Asp Leu Gln Asp Ile Ser Asp Ser Glu Arg Lys 
        275                 280                 285             


Thr Ser Ser Ala Glu Ser Ser Ser Ala Glu Ser Gly Ser Gly Ser Glu 
    290                 295                 300                 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ser Thr Ser 
305                 310                 315                 320 


Glu Glu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                325                 330                 335     


Thr Gly Ser Asn Ser Glu Glu Ala Ser Glu Gln Ser Ala Glu Glu Val 
            340                 345                 350         


Ser Glu Glu Glu Met Ser Glu Asp Glu Glu Arg Glu Asn Glu Asn His 
        355                 360                 365             


Leu Leu Val Val Pro Glu Ser Arg Phe Asp Arg Asp Ser Gly Glu Ser 
    370                 375                 380                 


Glu Glu Ala Glu Glu Glu Val Gly Glu Gly Thr Pro Gln Ser Ser Ala 
385                 390                 395                 400 


Leu Thr Glu Gly Asp Tyr Val Pro Asp Ser Pro Ala Leu Ser Pro Ile 
                405                 410                 415     


Glu Leu Lys Gln Glu Leu Pro Lys Tyr Leu Pro Ala Leu Gln Gly Cys 
            420                 425                 430         


Arg Ser Val Glu Glu Phe Gln Cys Leu Asn Arg Ile Glu Glu Gly Thr 
        435                 440                 445             


Tyr Gly Val Val Tyr Arg Ala Lys Asp Lys Lys Thr Asp Glu Ile Val 
    450                 455                 460                 


Ala Leu Lys Arg Leu Lys Met Glu Lys Glu Lys Glu Gly Phe Pro Ile 
465                 470                 475                 480 


Thr Ser Leu Arg Glu Ile Asn Thr Ile Leu Lys Ala Gln His Pro Asn 
                485                 490                 495     


Ile Val Thr Val Arg Glu Ile Val Val Gly Ser Asn Met Asp Lys Ile 
            500                 505                 510         


Tyr Ile Val Met Asn Tyr Val Glu His Asp Leu Lys Ser Leu Met Glu 
        515                 520                 525             


Thr Met Lys Gln Pro Phe Leu Pro Gly Glu Val Lys Thr Leu Met Ile 
    530                 535                 540                 


Gln Leu Leu Arg Gly Val Lys His Leu His Asp Asn Trp Ile Leu His 
545                 550                 555                 560 


Arg Asp Leu Lys Thr Ser Asn Leu Leu Leu Ser His Ala Gly Ile Leu 
                565                 570                 575     


Lys Val Gly Asp Phe Gly Leu Ala Arg Glu Tyr Gly Ser Pro Leu Lys 
            580                 585                 590         


Ala Tyr Thr Pro Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Leu 
        595                 600                 605             


Leu Leu Gly Ala Lys Glu Tyr Ser Thr Ala Val Asp Met Trp Ser Val 
    610                 615                 620                 


Gly Cys Ile Phe Gly Glu Leu Leu Thr Gln Lys Pro Leu Phe Pro Gly 
625                 630                 635                 640 


Lys Ser Glu Ile Asp Gln Ile Asn Lys Val Phe Lys Asp Leu Gly Thr 
                645                 650                 655     


Pro Ser Glu Lys Ile Trp Pro Gly Tyr Ser Glu Leu Pro Ala Val Lys 
            660                 665                 670         


Lys Met Thr Phe Ser Glu His Pro Tyr Asn Asn Leu Arg Lys Arg Phe 
        675                 680                 685             


Gly Ala Leu Leu Ser Asp Gln Gly Phe Asp Leu Met Asn Lys Phe Leu 
    690                 695                 700                 


Thr Tyr Phe Pro Gly Arg Arg Ile Ser Ala Glu Asp Gly Leu Lys His 
705                 710                 715                 720 


Glu Tyr Phe Arg Glu Thr Pro Leu Pro Ile Asp Pro Ser Met Phe Pro 
                725                 730                 735     


Thr Trp Pro Ala Lys Ser Glu Gln Gln Arg Val Lys Arg Gly Thr Ser 
            740                 745                 750         


Pro Arg Pro Pro Glu Gly Gly Leu Gly Tyr Ser Gln Leu Gly Asp Asp 
        755                 760                 765             


Asp Leu Lys Glu Thr Gly Phe His Leu Thr Thr Thr Asn Gln Gly Ala 
    770                 775                 780                 


Ser Ala Ala Gly Pro Gly Phe Ser Leu Lys Phe 
785                 790                 795 


<210>  1925
<211>  1481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK12__Homo_sapiens__NP_055898

<400>  1925

Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly 
1               5                   10                  15      


Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser 
            20                  25                  30          


Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys 
        35                  40                  45              


His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly 
    50                  55                  60                  


Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser 
65                  70                  75                  80  


Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn 
                85                  90                  95      


Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg 
            100                 105                 110         


His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr 
        115                 120                 125             


Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys 
    130                 135                 140                 


Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp 
145                 150                 155                 160 


Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser 
                165                 170                 175     


Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser 
            180                 185                 190         


Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys 
        195                 200                 205             


Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His 
    210                 215                 220                 


Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala 
225                 230                 235                 240 


Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser 
                245                 250                 255     


Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg 
            260                 265                 270         


Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser 
        275                 280                 285             


Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro 
    290                 295                 300                 


Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser 
305                 310                 315                 320 


Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe 
                325                 330                 335     


Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser 
            340                 345                 350         


Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser 
        355                 360                 365             


His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile 
    370                 375                 380                 


Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser 
385                 390                 395                 400 


Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp 
                405                 410                 415     


Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn 
            420                 425                 430         


Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro 
        435                 440                 445             


Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn 
    450                 455                 460                 


Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys 
465                 470                 475                 480 


Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys 
                485                 490                 495     


Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile 
            500                 505                 510         


Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro 
        515                 520                 525             


Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro 
    530                 535                 540                 


Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu 
545                 550                 555                 560 


Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val 
                565                 570                 575     


Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr 
            580                 585                 590         


Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser 
        595                 600                 605             


Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr 
    610                 615                 620                 


Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Asp Asp 
625                 630                 635                 640 


Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys 
                645                 650                 655     


Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro 
            660                 665                 670         


Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro 
        675                 680                 685             


Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile 
    690                 695                 700                 


Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly 
705                 710                 715                 720 


Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly 
                725                 730                 735     


Thr Tyr Gly Gln Val Tyr Lys Ala Lys Asp Lys Asp Thr Gly Glu Leu 
            740                 745                 750         


Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro 
        755                 760                 765             


Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg 
    770                 775                 780                 


Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu 
785                 790                 795                 800 


Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met 
                805                 810                 815     


Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser 
            820                 825                 830         


Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu 
        835                 840                 845             


Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn 
    850                 855                 860                 


Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu 
865                 870                 875                 880 


Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val 
                885                 890                 895     


Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg 
            900                 905                 910         


Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu 
        915                 920                 925             


Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln 
    930                 935                 940                 


Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp 
945                 950                 955                 960 


Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys 
                965                 970                 975     


Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala 
            980                 985                 990         


Ala Leu Asp Leu Leu Asp His Met  Leu Thr Leu Asp Pro  Ser Lys Arg 
        995                 1000                 1005             


Cys Thr  Ala Glu Gln Thr Leu  Gln Ser Asp Phe Leu  Lys Asp Val 
    1010                 1015                 1020             


Glu Leu  Ser Lys Met Ala Pro  Pro Asp Leu Pro His  Trp Gln Asp 
    1025                 1030                 1035             


Cys His  Glu Leu Trp Ser Lys  Lys Arg Arg Arg Gln  Arg Gln Ser 
    1040                 1045                 1050             


Gly Val  Val Val Glu Glu Pro  Pro Pro Ser Lys Thr  Ser Arg Lys 
    1055                 1060                 1065             


Glu Thr  Thr Ser Gly Thr Ser  Thr Glu Pro Val Lys  Asn Ser Ser 
    1070                 1075                 1080             


Pro Ala  Pro Pro Gln Pro Ala  Pro Gly Lys Val Glu  Ser Gly Ala 
    1085                 1090                 1095             


Gly Asp  Ala Ile Gly Leu Ala  Asp Ile Thr Gln Gln  Leu Asn Gln 
    1100                 1105                 1110             


Ser Glu  Leu Ala Val Leu Leu  Asn Leu Leu Gln Ser  Gln Thr Asp 
    1115                 1120                 1125             


Leu Ser  Ile Pro Gln Met Ala  Gln Leu Leu Asn Ile  His Ser Asn 
    1130                 1135                 1140             


Pro Glu  Met Gln Gln Gln Leu  Glu Ala Leu Asn Gln  Ser Ile Ser 
    1145                 1150                 1155             


Ala Leu  Thr Glu Ala Thr Ser  Gln Gln Gln Asp Ser  Glu Thr Met 
    1160                 1165                 1170             


Ala Pro  Glu Glu Ser Leu Lys  Glu Ala Pro Ser Ala  Pro Val Ile 
    1175                 1180                 1185             


Leu Pro  Ser Ala Glu Gln Thr  Thr Leu Glu Ala Ser  Ser Thr Pro 
    1190                 1195                 1200             


Ala Asp  Met Gln Asn Ile Leu  Ala Val Leu Leu Ser  Gln Leu Met 
    1205                 1210                 1215             


Lys Thr  Gln Glu Pro Ala Gly  Ser Leu Glu Glu Asn  Asn Ser Asp 
    1220                 1225                 1230             


Lys Asn  Ser Gly Pro Gln Gly  Pro Arg Arg Thr Pro  Thr Met Pro 
    1235                 1240                 1245             


Gln Glu  Glu Ala Ala Glu Lys  Arg Pro Pro Glu Pro  Pro Gly Pro 
    1250                 1255                 1260             


Pro Pro  Pro Pro Pro Pro Pro  Pro Leu Val Glu Gly  Asp Leu Ser 
    1265                 1270                 1275             


Ser Ala  Pro Gln Glu Leu Asn  Pro Ala Val Thr Ala  Ala Leu Leu 
    1280                 1285                 1290             


Gln Leu  Leu Ser Gln Pro Glu  Ala Glu Pro Pro Gly  His Leu Pro 
    1295                 1300                 1305             


His Glu  His Gln Ala Leu Arg  Pro Met Glu Tyr Ser  Thr Arg Pro 
    1310                 1315                 1320             


Arg Pro  Asn Arg Thr Tyr Gly  Asn Thr Asp Gly Pro  Glu Thr Gly 
    1325                 1330                 1335             


Phe Ser  Ala Ile Asp Thr Asp  Glu Arg Asn Ser Gly  Pro Ala Leu 
    1340                 1345                 1350             


Thr Glu  Ser Leu Val Gln Thr  Leu Val Lys Asn Arg  Thr Phe Ser 
    1355                 1360                 1365             


Gly Ser  Leu Ser His Leu Gly  Glu Ser Ser Ser Tyr  Gln Gly Thr 
    1370                 1375                 1380             


Gly Ser  Val Gln Phe Pro Gly  Asp Gln Asp Leu Arg  Phe Ala Arg 
    1385                 1390                 1395             


Val Pro  Leu Ala Leu His Pro  Val Val Gly Gln Pro  Phe Leu Lys 
    1400                 1405                 1410             


Ala Glu  Gly Ser Ser Asn Ser  Val Val His Ala Glu  Thr Lys Leu 
    1415                 1420                 1425             


Gln Asn  Tyr Gly Glu Leu Gly  Pro Gly Thr Thr Gly  Ala Ser Ser 
    1430                 1435                 1440             


Ser Gly  Ala Gly Leu His Trp  Gly Gly Pro Thr Gln  Ser Ser Ala 
    1445                 1450                 1455             


Tyr Gly  Lys Leu Tyr Arg Gly  Pro Thr Arg Val Pro  Pro Arg Gly 
    1460                 1465                 1470             


Gly Arg  Gly Arg Gly Val Pro  Tyr 
    1475                 1480     


<210>  1926
<211>  1512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK13__Homo_sapiens__NP_003709

<400>  1926

Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser 
1               5                   10                  15      


Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu 
            20                  25                  30          


Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu 
        35                  40                  45              


Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro 
    50                  55                  60                  


Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys 
65                  70                  75                  80  


Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys 
                85                  90                  95      


Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly 
            100                 105                 110         


Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln 
        115                 120                 125             


Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val 
    130                 135                 140                 


Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly 
145                 150                 155                 160 


Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu 
            180                 185                 190         


Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg 
        195                 200                 205             


Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly 
    210                 215                 220                 


Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu 
225                 230                 235                 240 


Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Ser Gly Gly 
                245                 250                 255     


Arg Arg Lys Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Ser Arg Lys 
            260                 265                 270         


Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu 
        275                 280                 285             


Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys 
    290                 295                 300                 


Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly 
305                 310                 315                 320 


Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg 
                325                 330                 335     


Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser 
            340                 345                 350         


Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro 
        355                 360                 365             


Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro 
    370                 375                 380                 


Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser 
385                 390                 395                 400 


Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser 
                405                 410                 415     


Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg 
            420                 425                 430         


Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser 
        435                 440                 445             


Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala 
    450                 455                 460                 


Ala Arg Ala Ala Glu Ala Ala Lys Ala Ala Glu Ala Thr Lys Ala Ala 
465                 470                 475                 480 


Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr 
                485                 490                 495     


Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val 
            500                 505                 510         


Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser 
        515                 520                 525             


Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln 
    530                 535                 540                 


Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys 
545                 550                 555                 560 


Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu 
                565                 570                 575     


Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly 
            580                 585                 590         


Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro 
        595                 600                 605             


Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser 
    610                 615                 620                 


Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys 
625                 630                 635                 640 


Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro 
                645                 650                 655     


Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr 
            660                 665                 670         


Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly 
        675                 680                 685             


Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys 
    690                 695                 700                 


Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr 
705                 710                 715                 720 


Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val 
                725                 730                 735     


Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu 
            740                 745                 750         


Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys 
        755                 760                 765             


Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys 
    770                 775                 780                 


Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly 
785                 790                 795                 800 


Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser 
                805                 810                 815     


Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn 
            820                 825                 830         


Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg 
        835                 840                 845             


Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser 
    850                 855                 860                 


Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg 
865                 870                 875                 880 


Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp 
                885                 890                 895     


Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro 
            900                 905                 910         


Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg 
        915                 920                 925             


Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu 
    930                 935                 940                 


Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu 
945                 950                 955                 960 


Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp 
                965                 970                 975     


Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala 
            980                 985                 990         


Leu Gln Cys Glu Phe Leu Arg Asp  Val Glu Pro Ser Lys  Met Pro Pro 
        995                 1000                 1005             


Pro Asp  Leu Pro Leu Trp Gln  Asp Cys His Glu Leu  Trp Ser Lys 
    1010                 1015                 1020             


Lys Arg  Arg Arg Gln Lys Gln  Met Gly Met Thr Asp  Asp Val Ser 
    1025                 1030                 1035             


Thr Ile  Lys Ala Pro Arg Lys  Asp Leu Ser Leu Gly  Leu Asp Asp 
    1040                 1045                 1050             


Ser Arg  Thr Asn Thr Pro Gln  Gly Val Leu Pro Ser  Ser Gln Leu 
    1055                 1060                 1065             


Lys Ser  Gln Gly Ser Ser Asn  Val Ala Pro Val Lys  Thr Gly Pro 
    1070                 1075                 1080             


Gly Gln  His Leu Asn His Ser  Glu Leu Ala Ile Leu  Leu Asn Leu 
    1085                 1090                 1095             


Leu Gln  Ser Lys Thr Ser Val  Asn Met Ala Asp Phe  Val Gln Val 
    1100                 1105                 1110             


Leu Asn  Ile Lys Val Asn Ser  Glu Thr Gln Gln Gln  Leu Asn Lys 
    1115                 1120                 1125             


Ile Asn  Leu Pro Ala Gly Ile  Leu Ala Thr Gly Glu  Lys Gln Thr 
    1130                 1135                 1140             


Asp Pro  Ser Thr Pro Gln Gln  Glu Ser Ser Lys Pro  Leu Gly Gly 
    1145                 1150                 1155             


Ile Gln  Pro Ser Ser Gln Thr  Ile Gln Pro Lys Val  Glu Thr Asp 
    1160                 1165                 1170             


Ala Ala  Gln Ala Ala Val Gln  Ser Ala Phe Ala Val  Leu Leu Thr 
    1175                 1180                 1185             


Gln Leu  Ile Lys Ala Gln Gln  Ser Lys Gln Lys Asp  Val Leu Leu 
    1190                 1195                 1200             


Glu Glu  Arg Glu Asn Gly Ser  Gly His Glu Ala Ser  Leu Gln Leu 
    1205                 1210                 1215             


Arg Pro  Pro Pro Glu Pro Ser  Thr Pro Val Ser Gly  Gln Asp Asp 
    1220                 1225                 1230             


Leu Ile  Gln His Gln Asp Met  Arg Ile Leu Glu Leu  Thr Pro Glu 
    1235                 1240                 1245             


Pro Asp  Arg Pro Arg Ile Leu  Pro Pro Asp Gln Arg  Pro Pro Glu 
    1250                 1255                 1260             


Pro Pro  Glu Pro Pro Pro Val  Thr Glu Glu Asp Leu  Asp Tyr Arg 
    1265                 1270                 1275             


Thr Glu  Asn Gln His Val Pro  Thr Thr Ser Ser Ser  Leu Thr Asp 
    1280                 1285                 1290             


Pro His  Ala Gly Val Lys Ala  Ala Leu Leu Gln Leu  Leu Ala Gln 
    1295                 1300                 1305             


His Gln  Pro Gln Asp Asp Pro  Lys Arg Glu Gly Gly  Ile Asp Tyr 
    1310                 1315                 1320             


Gln Ala  Gly Asp Thr Tyr Val  Ser Thr Ser Asp Tyr  Lys Asp Asn 
    1325                 1330                 1335             


Phe Gly  Ser Ser Ser Phe Ser  Ser Ala Pro Tyr Val  Ser Asn Asp 
    1340                 1345                 1350             


Gly Leu  Gly Ser Ser Ser Ala  Pro Pro Leu Glu Arg  Arg Ser Phe 
    1355                 1360                 1365             


Ile Gly  Asn Ser Asp Ile Gln  Ser Leu Asp Asn Tyr  Ser Thr Ala 
    1370                 1375                 1380             


Ser Ser  His Ser Gly Gly Pro  Pro Gln Pro Ser Ala  Phe Ser Glu 
    1385                 1390                 1395             


Ser Phe  Pro Ser Ser Val Ala  Gly Tyr Gly Asp Ile  Tyr Leu Asn 
    1400                 1405                 1410             


Ala Gly  Pro Met Leu Phe Ser  Gly Asp Lys Asp His  Arg Phe Glu 
    1415                 1420                 1425             


Tyr Ser  His Gly Pro Ile Ala  Val Leu Ala Asn Ser  Ser Asp Pro 
    1430                 1435                 1440             


Ser Thr  Gly Pro Glu Ser Thr  His Pro Leu Pro Ala  Lys Met His 
    1445                 1450                 1455             


Asn Tyr  Asn Tyr Gly Gly Asn  Leu Gln Glu Asn Pro  Ser Gly Pro 
    1460                 1465                 1470             


Ser Leu  Met His Gly Gln Thr  Trp Thr Ser Pro Ala  Gln Gly Pro 
    1475                 1480                 1485             


Gly Tyr  Ser Gln Gly Tyr Arg  Gly His Ile Ser Thr  Ser Thr Gly 
    1490                 1495                 1500             


Arg Gly  Arg Gly Arg Gly Leu  Pro Tyr 
    1505                 1510         


<210>  1927
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK14__Homo_sapiens__NP_001274064

<400>  1927

Met Cys Asp Leu Ile Glu Pro Gln Pro Ala Glu Lys Ile Gly Lys Met 
1               5                   10                  15      


Lys Lys Leu Arg Arg Thr Leu Ser Glu Ser Phe Ser Arg Ile Ala Leu 
            20                  25                  30          


Lys Lys Asp Asp Thr Thr Phe Asp Glu Ile Cys Val Thr Lys Met Ser 
        35                  40                  45              


Thr Arg Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu Asp Thr 
    50                  55                  60                  


Ile Pro Glu Asp Lys Lys Val Arg Val Gln Arg Thr Gln Ser Thr Phe 
65                  70                  75                  80  


Asp Pro Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His Ser Glu 
                85                  90                  95      


Asn Asn Ala Cys Ile Asn Phe Lys Thr Ser Ser Thr Gly Lys Glu Ser 
            100                 105                 110         


Pro Lys Val Arg Arg His Ser Ser Pro Ser Ser Pro Thr Ser Pro Lys 
        115                 120                 125             


Phe Gly Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly Glu Gly 
    130                 135                 140                 


Ser Tyr Ala Thr Val Tyr Lys Gly Lys Ser Lys Val Asn Gly Lys Leu 
145                 150                 155                 160 


Val Ala Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Thr Pro Phe 
                165                 170                 175     


Thr Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn 
            180                 185                 190         


Ile Val Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Leu 
        195                 200                 205             


Val Phe Glu Tyr Val His Thr Asp Leu Cys Gln Tyr Met Asp Lys His 
    210                 215                 220                 


Pro Gly Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu 
225                 230                 235                 240 


Leu Arg Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp 
                245                 250                 255     


Leu Lys Pro Gln Asn Leu Leu Ile Ser Asp Thr Gly Glu Leu Lys Leu 
            260                 265                 270         


Ala Asp Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His Thr Tyr 
        275                 280                 285             


Ser Asn Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu 
    290                 295                 300                 


Gly Ser Thr Glu Tyr Ser Thr Cys Leu Asp Met Trp Gly Val Gly Cys 
305                 310                 315                 320 


Ile Phe Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly Met Lys 
                325                 330                 335     


Asp Ile Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly Thr Pro 
            340                 345                 350         


Asn Glu Asp Thr Trp Pro Gly Val His Ser Leu Pro His Phe Lys Pro 
        355                 360                 365             


Glu Arg Phe Thr Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala Trp Asn 
    370                 375                 380                 


Lys Leu Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys Leu Leu 
385                 390                 395                 400 


Gln Cys Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu Ser His 
                405                 410                 415     


Glu Tyr Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Thr Asp Met 
            420                 425                 430         


Ser Ser Ile Phe Thr Val Pro Asn Val Arg Leu Gln Pro Glu Ala Gly 
        435                 440                 445             


Glu Ser Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys Ser Leu 
    450                 455                 460                 


Ser Asn Ser Lys His 
465                 


<210>  1928
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK15__Homo_sapiens__NP_001248364

<400>  1928

Met Gly Gln Glu Leu Cys Ala Lys Thr Val Gln Pro Gly Cys Ser Cys 
1               5                   10                  15      


Tyr His Cys Ser Glu Gly Gly Glu Ala His Ser Cys Arg Arg Ser Gln 
            20                  25                  30          


Pro Glu Thr Thr Glu Ala Ala Phe Lys Leu Thr Asp Leu Lys Glu Ala 
        35                  40                  45              


Ser Cys Ser Met Thr Ser Phe His Pro Arg Gly Leu Gln Ala Ala Arg 
    50                  55                  60                  


Ala Gln Lys Phe Lys Ser Lys Arg Pro Arg Ser Asn Ser Asp Cys Phe 
65                  70                  75                  80  


Gln Glu Glu Asp Leu Arg Gln Gly Phe Gln Trp Arg Lys Ser Leu Pro 
                85                  90                  95      


Phe Gly Ala Ala Ser Ser Tyr Leu Asn Leu Glu Lys Leu Gly Glu Gly 
            100                 105                 110         


Ser Tyr Ala Thr Val Tyr Lys Gly Ile Ser Arg Ile Asn Gly Gln Leu 
        115                 120                 125             


Val Ala Leu Lys Val Ile Ser Met Asn Ala Glu Glu Gly Val Pro Phe 
    130                 135                 140                 


Thr Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn 
145                 150                 155                 160 


Ile Val Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Phe 
                165                 170                 175     


Val Phe Glu Tyr Met His Thr Asp Leu Ala Gln Tyr Met Ser Gln His 
            180                 185                 190         


Pro Gly Gly Leu His Pro His Asn Val Arg Leu Phe Met Phe Gln Leu 
        195                 200                 205             


Leu Arg Gly Leu Ala Tyr Ile His His Gln His Val Leu His Arg Asp 
    210                 215                 220                 


Leu Lys Pro Gln Asn Leu Leu Ile Ser His Leu Gly Glu Leu Lys Leu 
225                 230                 235                 240 


Ala Asp Phe Gly Leu Ala Arg Ala Lys Ser Ile Pro Ser Gln Thr Tyr 
                245                 250                 255     


Ser Ser Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Ala Leu Leu 
            260                 265                 270         


Gly Ala Thr Glu Tyr Ser Ser Glu Leu Asp Ile Trp Gly Ala Gly Cys 
        275                 280                 285             


Ile Phe Ile Glu Met Phe Gln Gly Gln Pro Leu Phe Pro Gly Val Ser 
    290                 295                 300                 


Asn Ile Leu Glu Gln Leu Glu Lys Ile Trp Glu Val Leu Gly Val Pro 
305                 310                 315                 320 


Thr Glu Asp Thr Trp Pro Gly Val Ser Lys Leu Pro Asn Tyr Asn Pro 
                325                 330                 335     


Glu Trp Phe Pro Leu Pro Thr Pro Arg Ser Leu His Val Val Trp Asn 
            340                 345                 350         


Arg Leu Gly Arg Val Pro Glu Ala Glu Asp Leu Ala Ser Gln Met Leu 
        355                 360                 365             


Lys Gly Phe Pro Arg Asp Arg Val Ser Ala Gln Glu Ala Leu Val His 
    370                 375                 380                 


Asp Tyr Phe Ser Ala Leu Pro Ser Gln Leu Tyr Gln Leu Pro Asp Val 
385                 390                 395                 400 


Ser Gly Val Arg Leu Lys Pro Glu Met Cys Asp Leu Leu Ala Ser Tyr 
                405                 410                 415     


Gln Lys Gly His His Pro Ala Gln Phe Ser Lys Cys Trp 
            420                 425                 


<210>  1929
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK16__Homo_sapiens__NP_001163931

<400>  1929

Met Pro Leu Tyr Gly Arg Ala Arg Asp His Val Thr His Pro Ser Ile 
1               5                   10                  15      


Leu Gly Thr Arg Pro Gly Arg Pro Met Ala Gly Pro Ile Thr Ala Ala 
            20                  25                  30          


Val Pro Glu Lys Ile Cys Asn Gly Ala Phe Cys Ser Cys Ser Gly Ala 
        35                  40                  45              


Phe Pro Leu Asp Pro Asn Asn Pro Ser Leu Gly Pro Leu Pro Ser Ile 
    50                  55                  60                  


Ser His Leu Asn Leu Arg Thr Gln Ile Ala Met Asp Arg Met Lys Lys 
65                  70                  75                  80  


Ile Lys Arg Gln Leu Ser Met Thr Leu Arg Gly Gly Arg Gly Ile Asp 
                85                  90                  95      


Lys Thr Asn Gly Ala Pro Glu Gln Ile Gly Leu Asp Glu Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Asp Pro Gly Glu Ala Pro Thr Arg Ala Ala Pro Gly 
        115                 120                 125             


Glu Leu Arg Ser Ala Arg Gly Pro Leu Ser Ser Ala Pro Glu Ile Val 
    130                 135                 140                 


His Glu Asp Leu Lys Met Gly Ser Asp Gly Glu Ser Asp Gln Ala Ser 
145                 150                 155                 160 


Ala Thr Ser Ser Asp Glu Val Gln Ser Pro Val Arg Val Arg Met Arg 
                165                 170                 175     


Asn His Pro Pro Arg Lys Ile Ser Thr Glu Asp Ile Asn Lys Arg Leu 
            180                 185                 190         


Ser Leu Pro Ala Asp Ile Arg Leu Pro Glu Gly Tyr Leu Glu Lys Leu 
        195                 200                 205             


Thr Leu Asn Ser Pro Ile Phe Asp Lys Pro Leu Ser Arg Arg Leu Arg 
    210                 215                 220                 


Arg Val Ser Leu Ser Glu Ile Gly Phe Gly Lys Leu Glu Thr Tyr Ile 
225                 230                 235                 240 


Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val Tyr Lys Gly 
                245                 250                 255     


Lys Ser Lys Leu Thr Asp Asn Leu Val Ala Leu Lys Glu Ile Arg Leu 
            260                 265                 270         


Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu Val Ser Leu 
        275                 280                 285             


Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His Asp Ile Ile 
    290                 295                 300                 


His Thr Glu Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu Asp Lys Asp 
305                 310                 315                 320 


Leu Lys Gln Tyr Leu Asp Asp Cys Gly Asn Ile Ile Asn Met His Asn 
                325                 330                 335     


Val Lys Leu Phe Leu Phe Gln Leu Leu Arg Gly Leu Ala Tyr Cys His 
            340                 345                 350         


Arg Gln Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu Ile 
        355                 360                 365             


Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala 
    370                 375                 380                 


Lys Ser Ile Pro Thr Lys Thr Tyr Ser Asn Glu Val Val Thr Leu Trp 
385                 390                 395                 400 


Tyr Arg Pro Pro Asp Ile Leu Leu Gly Ser Thr Asp Tyr Ser Thr Gln 
                405                 410                 415     


Ile Asp Met Trp Gly Val Gly Cys Ile Phe Tyr Glu Met Ala Thr Gly 
            420                 425                 430         


Arg Pro Leu Phe Pro Gly Ser Thr Val Glu Glu Gln Leu His Phe Ile 
        435                 440                 445             


Phe Arg Ile Leu Gly Thr Pro Thr Glu Glu Thr Trp Pro Gly Ile Leu 
    450                 455                 460                 


Ser Asn Glu Glu Phe Lys Thr Tyr Asn Tyr Pro Lys Tyr Arg Ala Glu 
465                 470                 475                 480 


Ala Leu Leu Ser His Ala Pro Arg Leu Asp Ser Asp Gly Ala Asp Leu 
                485                 490                 495     


Leu Thr Lys Leu Leu Gln Phe Glu Gly Arg Asn Arg Ile Ser Ala Glu 
            500                 505                 510         


Asp Ala Met Lys His Pro Phe Phe Leu Ser Leu Gly Glu Arg Ile His 
        515                 520                 525             


Lys Leu Pro Asp Thr Thr Ser Ile Phe Ala Leu Lys Glu Ile Gln Leu 
    530                 535                 540                 


Gln Lys Glu Ala Ser Leu Arg Ser Ser Ser Met Pro Asp Ser Gly Arg 
545                 550                 555                 560 


Pro Ala Phe Arg Val Val Asp Thr Glu Phe 
                565                 570 


<210>  1930
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK17__Homo_sapiens__NP_002586

<400>  1930

Met Lys Lys Phe Lys Arg Arg Leu Ser Leu Thr Leu Arg Gly Ser Gln 
1               5                   10                  15      


Thr Ile Asp Glu Ser Leu Ser Glu Leu Ala Glu Gln Met Thr Ile Glu 
            20                  25                  30          


Glu Asn Ser Ser Lys Asp Asn Glu Pro Ile Val Lys Asn Gly Arg Pro 
        35                  40                  45              


Pro Thr Ser His Ser Met His Ser Phe Leu His Gln Tyr Thr Gly Ser 
    50                  55                  60                  


Phe Lys Lys Pro Pro Leu Arg Arg Pro His Ser Val Ile Gly Gly Ser 
65                  70                  75                  80  


Leu Gly Ser Phe Met Ala Met Pro Arg Asn Gly Ser Arg Leu Asp Ile 
                85                  90                  95      


Val His Glu Asn Leu Lys Met Gly Ser Asp Gly Glu Ser Asp Gln Ala 
            100                 105                 110         


Ser Gly Thr Ser Ser Asp Glu Val Gln Ser Pro Thr Gly Val Cys Leu 
        115                 120                 125             


Arg Asn Arg Ile His Arg Arg Ile Ser Met Glu Asp Leu Asn Lys Arg 
    130                 135                 140                 


Leu Ser Leu Pro Ala Asp Ile Arg Ile Pro Asp Gly Tyr Leu Glu Lys 
145                 150                 155                 160 


Leu Gln Ile Asn Ser Pro Pro Phe Asp Gln Pro Met Ser Arg Arg Ser 
                165                 170                 175     


Arg Arg Ala Ser Leu Ser Glu Ile Gly Phe Gly Lys Met Glu Thr Tyr 
            180                 185                 190         


Ile Lys Leu Glu Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val Tyr Lys 
        195                 200                 205             


Gly Arg Ser Lys Leu Thr Glu Asn Leu Val Ala Leu Lys Glu Ile Arg 
    210                 215                 220                 


Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu Val Ser 
225                 230                 235                 240 


Leu Leu Lys Asp Leu Lys His Ala Asn Ile Val Thr Leu His Asp Ile 
                245                 250                 255     


Val His Thr Asp Lys Ser Leu Thr Leu Val Phe Glu Tyr Leu Asp Lys 
            260                 265                 270         


Asp Leu Lys Gln Tyr Met Asp Asp Cys Gly Asn Ile Met Ser Met His 
        275                 280                 285             


Asn Val Lys Leu Phe Leu Tyr Gln Ile Leu Arg Gly Leu Ala Tyr Cys 
    290                 295                 300                 


His Arg Arg Lys Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu 
305                 310                 315                 320 


Ile Asn Glu Lys Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg 
                325                 330                 335     


Ala Lys Ser Val Pro Thr Lys Thr Tyr Ser Asn Glu Val Val Thr Leu 
            340                 345                 350         


Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser Ser Glu Tyr Ser Thr 
        355                 360                 365             


Gln Ile Asp Met Trp Gly Val Gly Cys Ile Phe Phe Glu Met Ala Ser 
    370                 375                 380                 


Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Glu Asp Glu Leu His Leu 
385                 390                 395                 400 


Ile Phe Arg Leu Leu Gly Thr Pro Ser Gln Glu Thr Trp Pro Gly Ile 
                405                 410                 415     


Ser Ser Asn Glu Glu Phe Lys Asn Tyr Asn Phe Pro Lys Tyr Lys Pro 
            420                 425                 430         


Gln Pro Leu Ile Asn His Ala Pro Arg Leu Asp Ser Glu Gly Ile Glu 
        435                 440                 445             


Leu Ile Thr Lys Phe Leu Gln Tyr Glu Ser Lys Lys Arg Val Ser Ala 
    450                 455                 460                 


Glu Glu Ala Met Lys His Val Tyr Phe Arg Ser Leu Gly Pro Arg Ile 
465                 470                 475                 480 


His Ala Leu Pro Glu Ser Val Ser Ile Phe Ser Leu Lys Glu Ile Gln 
                485                 490                 495     


Leu Gln Lys Asp Pro Gly Phe Arg Asn Ser Ser Tyr Pro Glu Thr Gly 
            500                 505                 510         


His Gly Lys Asn Arg Arg Gln Ser Met Leu Phe 
        515                 520             


<210>  1931
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK18__Homo_sapiens__NP_002587

<400>  1931

Met Ile Met Asn Lys Met Lys Asn Phe Lys Arg Arg Phe Ser Leu Ser 
1               5                   10                  15      


Val Pro Arg Thr Glu Thr Ile Glu Glu Ser Leu Ala Glu Phe Thr Glu 
            20                  25                  30          


Gln Phe Asn Gln Leu His Asn Arg Arg Asn Glu Asn Leu Gln Leu Gly 
        35                  40                  45              


Pro Leu Gly Arg Asp Pro Pro Gln Glu Cys Ser Thr Phe Ser Pro Thr 
    50                  55                  60                  


Asp Ser Gly Glu Glu Pro Gly Gln Leu Ser Pro Gly Val Gln Phe Gln 
65                  70                  75                  80  


Arg Arg Gln Asn Gln Arg Arg Phe Ser Met Glu Asp Val Ser Lys Arg 
                85                  90                  95      


Leu Ser Leu Pro Met Asp Ile Arg Leu Pro Gln Glu Phe Leu Gln Lys 
            100                 105                 110         


Leu Gln Met Glu Ser Pro Asp Leu Pro Lys Pro Leu Ser Arg Met Ser 
        115                 120                 125             


Arg Arg Ala Ser Leu Ser Asp Ile Gly Phe Gly Lys Leu Glu Thr Tyr 
    130                 135                 140                 


Val Lys Leu Asp Lys Leu Gly Glu Gly Thr Tyr Ala Thr Val Phe Lys 
145                 150                 155                 160 


Gly Arg Ser Lys Leu Thr Glu Asn Leu Val Ala Leu Lys Glu Ile Arg 
                165                 170                 175     


Leu Glu His Glu Glu Gly Ala Pro Cys Thr Ala Ile Arg Glu Val Ser 
            180                 185                 190         


Leu Leu Lys Asn Leu Lys His Ala Asn Ile Val Thr Leu His Asp Leu 
        195                 200                 205             


Ile His Thr Asp Arg Ser Leu Thr Leu Val Phe Glu Tyr Leu Asp Ser 
    210                 215                 220                 


Asp Leu Lys Gln Tyr Leu Asp His Cys Gly Asn Leu Met Ser Met His 
225                 230                 235                 240 


Asn Val Lys Ile Phe Met Phe Gln Leu Leu Arg Gly Leu Ala Tyr Cys 
                245                 250                 255     


His His Arg Lys Ile Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu 
            260                 265                 270         


Ile Asn Glu Arg Gly Glu Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg 
        275                 280                 285             


Ala Lys Ser Val Pro Thr Lys Thr Tyr Ser Asn Glu Val Val Thr Leu 
    290                 295                 300                 


Trp Tyr Arg Pro Pro Asp Val Leu Leu Gly Ser Thr Glu Tyr Ser Thr 
305                 310                 315                 320 


Pro Ile Asp Met Trp Gly Val Gly Cys Ile His Tyr Glu Met Ala Thr 
                325                 330                 335     


Gly Arg Pro Leu Phe Pro Gly Ser Thr Val Lys Glu Glu Leu His Leu 
            340                 345                 350         


Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu Glu Thr Trp Pro Gly Val 
        355                 360                 365             


Thr Ala Phe Ser Glu Phe Arg Thr Tyr Ser Phe Pro Cys Tyr Leu Pro 
    370                 375                 380                 


Gln Pro Leu Ile Asn His Ala Pro Arg Leu Asp Thr Asp Gly Ile His 
385                 390                 395                 400 


Leu Leu Ser Ser Leu Leu Leu Tyr Glu Ser Lys Ser Arg Met Ser Ala 
                405                 410                 415     


Glu Ala Ala Leu Ser His Ser Tyr Phe Arg Ser Leu Gly Glu Arg Val 
            420                 425                 430         


His Gln Leu Glu Asp Thr Ala Ser Ile Phe Ser Leu Lys Glu Ile Gln 
        435                 440                 445             


Leu Gln Lys Asp Pro Gly Tyr Arg Gly Leu Ala Phe Gln Gln Pro Gly 
    450                 455                 460                 


Arg Gly Lys Asn Arg Arg Gln Ser Ile Phe 
465                 470                 


<210>  1932
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK19__Homo_sapiens__NP_001287892

<400>  1932

Met Ser Ala Cys Arg Glu Ile Ala Leu Leu Arg Glu Leu Lys His Pro 
1               5                   10                  15      


Asn Val Ile Ala Leu Gln Lys Val Phe Leu Ser His Ser Asp Arg Lys 
            20                  25                  30          


Val Trp Leu Leu Phe Asp Tyr Ala Glu His Asp Leu Trp His Ile Ile 
        35                  40                  45              


Lys Phe His Arg Ala Ser Lys Ala Asn Lys Lys Pro Met Gln Leu Pro 
    50                  55                  60                  


Arg Ser Met Val Lys Ser Leu Leu Tyr Gln Ile Leu Asp Gly Ile His 
65                  70                  75                  80  


Tyr Leu His Ala Asn Trp Val Leu His Arg Asp Leu Lys Pro Ala Asn 
                85                  90                  95      


Ile Leu Val Met Gly Glu Gly Pro Glu Arg Gly Arg Val Lys Ile Ala 
            100                 105                 110         


Asp Met Gly Phe Ala Arg Leu Phe Asn Ser Pro Leu Lys Pro Leu Ala 
        115                 120                 125             


Asp Leu Asp Pro Val Val Val Thr Phe Trp Tyr Arg Ala Pro Glu Leu 
    130                 135                 140                 


Leu Leu Gly Ala Arg His Tyr Thr Lys Ala Ile Asp Ile Trp Ala Ile 
145                 150                 155                 160 


Gly Cys Ile Phe Ala Glu Leu Leu Thr Ser Glu Pro Ile Phe His Cys 
                165                 170                 175     


Arg Gln Glu Asp Ile Lys Thr Ser Asn Pro Phe His His Asp Gln Leu 
            180                 185                 190         


Asp Arg Ile Phe Ser Val Met Gly Phe Pro Ala Asp Lys Asp Trp Glu 
        195                 200                 205             


Asp Ile Arg Lys Met Pro Glu Tyr Pro Thr Leu Gln Lys Asp Phe Arg 
    210                 215                 220                 


Arg Thr Thr Tyr Ala Asn Ser Ser Leu Ile Lys Tyr Met Glu Lys His 
225                 230                 235                 240 


Lys Val Lys Pro Asp Ser Lys Val Phe Leu Leu Leu Gln Lys Leu Leu 
                245                 250                 255     


Thr Met Asp Pro Thr Lys Arg Ile Thr Ser Glu Gln Ala Leu Gln Asp 
            260                 265                 270         


Pro Tyr Phe Gln Glu Asp Pro Leu Pro Thr Leu Asp Val Phe Ala Gly 
        275                 280                 285             


Cys Gln Ile Pro Tyr Pro Lys Arg Glu Phe Leu Asn Glu Asp Asp Pro 
    290                 295                 300                 


Glu Glu Lys Gly Asp Lys Asn Gln Gln Gln Gln Gln Asn Gln His Gln 
305                 310                 315                 320 


Gln Pro Thr Ala Pro Pro Gln Gln Ala Ala Ala Pro Pro Gln Ala Pro 
                325                 330                 335     


Pro Pro Gln Gln Asn Ser Thr Gln Thr Asn Gly Thr Ala Gly Gly Ala 
            340                 345                 350         


Gly Ala Gly Val Gly Gly Thr Gly Ala Gly Leu Gln His Ser Gln Asp 
        355                 360                 365             


Ser Ser Leu Asn Gln Val Pro Pro Asn Lys Lys Pro Arg Leu Gly Pro 
    370                 375                 380                 


Ser Gly Ala Asn Ser Gly Gly Pro Val Met Pro Ser Asp Tyr Gln His 
385                 390                 395                 400 


Ser Ser Ser Arg Leu Asn Tyr Gln Ser Ser Val Gln Gly Ser Ser Gln 
                405                 410                 415     


Ser Gln Ser Thr Leu Gly Tyr Ser Ser Ser Ser Gln Gln Ser Ser Gln 
            420                 425                 430         


Tyr His Pro Ser His Gln Ala His Arg Tyr 
        435                 440         


<210>  1933
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK1__Homo_sapiens__NP_203698

<400>  1933

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Val Val Thr Leu Trp Tyr 
            100                 105                 110         


Arg Ser Pro Glu Val Leu Leu Gly Ser Ala Arg Tyr Ser Thr Pro Val 
        115                 120                 125             


Asp Ile Trp Ser Ile Gly Thr Ile Phe Ala Glu Leu Ala Thr Lys Lys 
    130                 135                 140                 


Pro Leu Phe His Gly Asp Ser Glu Ile Asp Gln Leu Phe Arg Ile Phe 
145                 150                 155                 160 


Arg Ala Leu Gly Thr Pro Asn Asn Glu Val Trp Pro Glu Val Glu Ser 
                165                 170                 175     


Leu Gln Asp Tyr Lys Asn Thr Phe Pro Lys Trp Lys Pro Gly Ser Leu 
            180                 185                 190         


Ala Ser His Val Lys Asn Leu Asp Glu Asn Gly Leu Asp Leu Leu Ser 
        195                 200                 205             


Lys Met Leu Ile Tyr Asp Pro Ala Lys Arg Ile Ser Gly Lys Met Ala 
    210                 215                 220                 


Leu Asn His Pro Tyr Phe Asn Asp Leu Asp Asn Gln Ile Lys Lys Met 
225                 230                 235                 240 


<210>  1934
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK20__Homo_sapiens__NP_001034892

<400>  1934

Met Asp Gln Tyr Cys Ile Leu Gly Arg Ile Gly Glu Gly Ala His Gly 
1               5                   10                  15      


Ile Val Phe Lys Ala Lys His Val Glu Thr Gly Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Lys Val Ala Leu Arg Arg Leu Glu Asp Gly Phe Pro Asn Gln Ala 
        35                  40                  45              


Leu Arg Glu Ile Lys Ala Leu Gln Glu Met Glu Asp Asn Gln Tyr Val 
    50                  55                  60                  


Val Gln Leu Lys Ala Val Phe Pro His Gly Gly Gly Phe Val Leu Ala 
65                  70                  75                  80  


Phe Glu Phe Met Leu Ser Asp Leu Ala Glu Val Val Arg His Ala Gln 
                85                  90                  95      


Arg Pro Leu Ala Gln Ala Gln Val Lys Ser Tyr Leu Gln Met Leu Leu 
            100                 105                 110         


Lys Gly Val Ala Phe Cys His Ala Asn Asn Ile Val His Arg Asp Leu 
        115                 120                 125             


Lys Pro Ala Asn Leu Leu Ile Ser Ala Ser Gly Gln Leu Lys Ile Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Val Phe Ser Pro Asp Gly Ser Arg Leu Tyr 
145                 150                 155                 160 


Thr His Gln Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Tyr 
                165                 170                 175     


Gly Ala Arg Gln Tyr Asp Gln Gly Val Asp Leu Trp Ser Val Gly Cys 
            180                 185                 190         


Ile Met Gly Glu Leu Leu Asn Gly Ser Pro Leu Phe Pro Gly Lys Asn 
        195                 200                 205             


Asp Ile Glu Gln Leu Cys Tyr Val Leu Arg Ile Leu Gly Thr Pro Asn 
    210                 215                 220                 


Pro Gln Val Trp Pro Glu Leu Thr Glu Leu Pro Asp Tyr Asn Lys Ile 
225                 230                 235                 240 


Ser Phe Lys Glu Gln Val Pro Met Pro Leu Glu Glu Val Leu Pro Asp 
                245                 250                 255     


Val Ser Pro Gln Ala Leu Asp Leu Leu Gly Gln Phe Leu Leu Tyr Pro 
            260                 265                 270         


Pro His Gln Arg Ile Ala Ala Ser Lys Ala Leu Leu His Gln Tyr Phe 
        275                 280                 285             


Phe Thr Ala Pro Leu Pro Ala His Pro Ser Glu Leu Pro Ile Pro Gln 
    290                 295                 300                 


Arg Leu Gly Gly Pro Ala Pro Lys Ala His Pro Gly Pro Pro His Ile 
305                 310                 315                 320 


His Asp Phe His Val Asp Arg Pro Leu Glu Glu Ser Leu Leu Asn Pro 
                325                 330                 335     


Glu Leu Ile Arg Pro Phe Ile Leu Glu Gly 
            340                 345     


<210>  1935
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK2AP1__Homo_sapiens__NP_004633

<400>  1935

Met Ser Tyr Lys Pro Asn Leu Ala Ala His Met Pro Ala Ala Ala Leu 
1               5                   10                  15      


Asn Ala Ala Gly Ser Val His Ser Pro Ser Thr Ser Met Ala Thr Ser 
            20                  25                  30          


Ser Gln Tyr Arg Gln Leu Leu Ser Asp Tyr Gly Pro Pro Ser Leu Gly 
        35                  40                  45              


Tyr Thr Gln Gly Thr Gly Asn Ser Gln Val Pro Gln Ser Lys Tyr Ala 
    50                  55                  60                  


Glu Leu Leu Ala Ile Ile Glu Glu Leu Gly Lys Glu Ile Arg Pro Thr 
65                  70                  75                  80  


Tyr Ala Gly Ser Lys Ser Ala Met Glu Arg Leu Lys Arg Gly Ile Ile 
                85                  90                  95      


His Ala Arg Gly Leu Val Arg Glu Cys Leu Ala Glu Thr Glu Arg Asn 
            100                 105                 110         


Ala Arg Ser 
        115 


<210>  1936
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK2AP2__Homo_sapiens__NP_005842

<400>  1936

Met Ser Tyr Lys Pro Ile Ala Pro Ala Pro Ser Ser Thr Pro Gly Ser 
1               5                   10                  15      


Ser Thr Pro Gly Pro Gly Thr Pro Val Pro Thr Gly Ser Val Pro Ser 
            20                  25                  30          


Pro Ser Gly Ser Val Pro Gly Ala Gly Ala Pro Phe Arg Pro Leu Phe 
        35                  40                  45              


Asn Asp Phe Gly Pro Pro Ser Met Gly Tyr Val Gln Ala Met Lys Pro 
    50                  55                  60                  


Pro Gly Ala Gln Gly Ser Gln Ser Thr Tyr Thr Asp Leu Leu Ser Val 
65                  70                  75                  80  


Ile Glu Glu Met Gly Lys Glu Ile Arg Pro Thr Tyr Ala Gly Ser Lys 
                85                  90                  95      


Ser Ala Met Glu Arg Leu Lys Arg Gly Ile Ile His Ala Arg Ala Leu 
            100                 105                 110         


Val Arg Glu Cys Leu Ala Glu Thr Glu Arg Asn Ala Arg Thr 
        115                 120                 125     


<210>  1937
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK2__Homo_sapiens__NP_001789

<400>  1937

Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Thr Glu Thr Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 
    50                  55                  60                  


Lys Leu Leu Asp Val Ile His Thr Glu Asn Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 
                85                  90                  95      


Thr Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Thr Glu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Thr Tyr Thr 
145                 150                 155                 160 


His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Cys Lys Tyr Tyr Ser Thr Ala Val Asp Ile Trp Ser Leu Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Thr Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Thr Leu Gly Thr Pro Asp Glu 
    210                 215                 220                 


Val Val Trp Pro Gly Val Thr Ser Met Pro Asp Tyr Lys Pro Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp 
                245                 250                 255     


Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn 
            260                 265                 270         


Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp 
        275                 280                 285             


Val Thr Lys Pro Val Pro His Leu Arg Leu 
    290                 295             


<210>  1938
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK3__Homo_sapiens__NP_001249

<400>  1938

Met Asp Met Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Lys Asn Arg Glu Thr Gly Gln Leu Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Leu Glu Met Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Lys His Pro Asn Ile Val 
    50                  55                  60                  


Arg Leu Leu Asp Val Val His Asn Glu Arg Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Gln Asp Leu Lys Lys Tyr Met Asp Ser Thr Pro Gly 
                85                  90                  95      


Ser Glu Leu Pro Leu His Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Val Ser Phe Cys His Ser His Arg Val Ile His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Glu Leu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Leu Arg Thr Tyr Thr 
145                 150                 155                 160 


His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Ser Lys Phe Tyr Thr Thr Ala Val Asp Ile Trp Ser Ile Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Thr Arg Lys Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Met Leu Gly Thr Pro Ser Glu 
    210                 215                 220                 


Asp Thr Trp Pro Gly Val Thr Gln Leu Pro Asp Tyr Lys Gly Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Thr Arg Lys Gly Leu Glu Glu Ile Val Pro Asn Leu Glu 
                245                 250                 255     


Pro Glu Gly Arg Asp Leu Leu Met Gln Leu Leu Gln Tyr Asp Pro Ser 
            260                 265                 270         


Gln Arg Ile Thr Ala Lys Thr Ala Leu Ala His Pro Tyr Phe Ser Ser 
        275                 280                 285             


Pro Glu Pro Ser Pro Ala Ala Arg Gln Tyr Val Leu Gln Arg Phe Arg 
    290                 295                 300                 


His 
305 


<210>  1939
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK4__Homo_sapiens__NP_000066

<400>  1939

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  1940
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK5__Homo_sapiens__NP_001157882

<400>  1940

Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Asn Gly Glu Leu Lys Leu Ala Asp 
            100                 105                 110         


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
        115                 120                 125             


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
    130                 135                 140                 


Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
145                 150                 155                 160 


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
                165                 170                 175     


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu 
            180                 185                 190         


Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
        195                 200                 205             


Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn 
    210                 215                 220                 


Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
225                 230                 235                 240 


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
                245                 250                 255     


Phe Cys Pro Pro 
            260 


<210>  1941
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK5R1__Homo_sapiens__XP_011523740

<400>  1941

Met Gly Thr Val Leu Ser Leu Ser Pro Ser Tyr Arg Lys Ala Thr Leu 
1               5                   10                  15      


Phe Glu Asp Gly Ala Ala Thr Val Gly His Tyr Thr Ala Val Gln Asn 
            20                  25                  30          


Ser Lys Asn Ala Lys Asp Lys Asn Leu Lys Arg His Ser Ile Ile Ser 
        35                  40                  45              


Val Leu Pro Trp Lys Arg Ile Val Ala Val Ser Ala Lys Lys Lys Asn 
    50                  55                  60                  


Ser Lys Lys Val Gln Pro Asn Ser Ser Tyr Gln Asn Asn Ile Thr His 
65                  70                  75                  80  


Leu Asn Asn Glu Asn Leu Lys Lys Ser Leu Ser Cys Ala Asn Leu Ser 
                85                  90                  95      


Thr Phe Ala Gln Pro Pro Pro Ala Gln Pro Pro Ala Pro Pro Ala Ser 
            100                 105                 110         


Gln Leu Ser Gly Ser Gln Thr Gly Gly Ser Ser Ser Val Lys Lys Ala 
        115                 120                 125             


Pro His Pro Ala Val Thr Ser Ala Gly Thr Pro Lys Arg Val Ile Val 
    130                 135                 140                 


Gln Ala Ser Thr Ser Glu Leu Leu Arg Cys Leu Gly Glu Phe Leu Cys 
145                 150                 155                 160 


Arg Arg Cys Tyr Arg Leu Lys His Leu Ser Pro Thr Asp Pro Val Leu 
                165                 170                 175     


Trp Leu Arg Ser Val Asp Arg Ser Leu Leu Leu Gln Gly Trp Gln Asp 
            180                 185                 190         


Gln Gly Phe Ile Thr Pro Ala Asn Val Val Phe Leu Tyr Met Leu Cys 
        195                 200                 205             


Arg Asp Val Ile Ser Ser Glu Val Gly Ser Asp His Glu Leu Gln Ala 
    210                 215                 220                 


Val Leu Leu Thr Cys Leu Tyr Leu Ser Tyr Ser Tyr Met Gly Asn Glu 
225                 230                 235                 240 


Ile Ser Tyr Pro Leu Lys Pro Phe Leu Val Glu Ser Cys Lys Glu Ala 
                245                 250                 255     


Phe Trp Asp Arg Cys Leu Ser Val Ile Asn Leu Met Ser Ser Lys Met 
            260                 265                 270         


Leu Gln Ile Asn Ala Asp Pro His Tyr Phe Thr Gln Val Phe Ser Asp 
        275                 280                 285             


Leu Lys Asn Glu Ser Gly Gln Glu Asp Lys Lys Arg Leu Leu Leu Gly 
    290                 295                 300                 


Leu Asp Arg 
305         


<210>  1942
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK5R2__Homo_sapiens__NP_003927

<400>  1942

Met Gly Thr Val Leu Ser Leu Ser Pro Ala Ser Ser Ala Lys Gly Arg 
1               5                   10                  15      


Arg Pro Gly Gly Leu Pro Glu Glu Lys Lys Lys Ala Pro Pro Ala Gly 
            20                  25                  30          


Asp Glu Ala Leu Gly Gly Tyr Gly Ala Pro Pro Val Gly Lys Gly Gly 
        35                  40                  45              


Lys Gly Glu Ser Arg Leu Lys Arg Pro Ser Val Leu Ile Ser Ala Leu 
    50                  55                  60                  


Thr Trp Lys Arg Leu Val Ala Ala Ser Ala Lys Lys Lys Lys Gly Ser 
65                  70                  75                  80  


Lys Lys Val Thr Pro Lys Pro Ala Ser Thr Gly Pro Asp Pro Leu Val 
                85                  90                  95      


Gln Gln Arg Asn Arg Glu Asn Leu Leu Arg Lys Gly Arg Asp Pro Pro 
            100                 105                 110         


Asp Gly Gly Gly Thr Ala Lys Pro Leu Ala Val Pro Val Pro Thr Val 
        115                 120                 125             


Pro Ala Ala Ala Ala Thr Cys Glu Pro Pro Ser Gly Gly Ser Ala Ala 
    130                 135                 140                 


Ala Gln Pro Pro Gly Ser Gly Gly Gly Lys Pro Pro Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Ala Pro Gln Val Ala Pro Pro Val Pro Gly Gly Ser Pro Arg Arg 
                165                 170                 175     


Val Ile Val Gln Ala Ser Thr Gly Glu Leu Leu Arg Cys Leu Gly Asp 
            180                 185                 190         


Phe Val Cys Arg Arg Cys Tyr Arg Leu Lys Glu Leu Ser Pro Gly Glu 
        195                 200                 205             


Leu Val Gly Trp Phe Arg Gly Val Asp Arg Ser Leu Leu Leu Gln Gly 
    210                 215                 220                 


Trp Gln Asp Gln Ala Phe Ile Thr Pro Ala Asn Leu Val Phe Val Tyr 
225                 230                 235                 240 


Leu Leu Cys Arg Glu Ser Leu Arg Gly Asp Glu Leu Ala Ser Ala Ala 
                245                 250                 255     


Glu Leu Gln Ala Ala Phe Leu Thr Cys Leu Tyr Leu Ala Tyr Ser Tyr 
            260                 265                 270         


Met Gly Asn Glu Ile Ser Tyr Pro Leu Lys Pro Phe Leu Val Glu Pro 
        275                 280                 285             


Asp Lys Glu Arg Phe Trp Gln Arg Cys Leu Arg Leu Ile Gln Arg Leu 
    290                 295                 300                 


Ser Pro Gln Met Leu Arg Leu Asn Ala Asp Pro His Phe Phe Thr Gln 
305                 310                 315                 320 


Val Phe Gln Asp Leu Lys Asn Glu Gly Glu Ala Ala Ala Ser Gly Gly 
                325                 330                 335     


Gly Pro Pro Ser Gly Gly Ala Pro Ala Ala Ser Ser Ala Ala Arg Asp 
            340                 345                 350         


Ser Cys Ala Ala Gly Thr Lys His Trp Thr Met Asn Leu Asp Arg 
        355                 360                 365         


<210>  1943
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK5RAP1__Homo_sapiens__NP_001265096

<400>  1943

Met His Pro Leu Gln Cys Val Leu Gln Val Gln Arg Ser Leu Gly Trp 
1               5                   10                  15      


Gly Pro Leu Ala Ser Val Ser Trp Leu Ser Leu Arg Met Cys Arg Ala 
            20                  25                  30          


His Ser Ser Leu Ser Ser Thr Met Cys Pro Ser Pro Glu Arg Gln Glu 
        35                  40                  45              


Asp Gly Ala Arg Lys Asp Phe Ser Ser Arg Leu Ala Ala Gly Pro Thr 
    50                  55                  60                  


Phe Gln His Phe Leu Lys Ser Ala Ser Ala Pro Gln Glu Lys Leu Ser 
65                  70                  75                  80  


Ser Glu Val Glu Asp Pro Pro Pro Tyr Leu Met Met Asp Glu Leu Leu 
                85                  90                  95      


Gly Arg Gln Arg Lys Val Tyr Leu Glu Thr Tyr Gly Cys Gln Met Asn 
            100                 105                 110         


Val Asn Asp Thr Glu Ile Ala Trp Ser Ile Leu Gln Lys Ser Gly Tyr 
        115                 120                 125             


Leu Arg Thr Ser Asn Leu Gln Glu Ala Asp Val Ile Leu Leu Val Thr 
    130                 135                 140                 


Cys Ser Ile Arg Glu Lys Ala Glu Gln Thr Ile Trp Asn Arg Leu His 
145                 150                 155                 160 


Gln Leu Lys Ala Leu Lys Thr Arg Arg Pro Arg Ser Arg Val Pro Leu 
                165                 170                 175     


Arg Ile Gly Ile Leu Gly Cys Met Ala Glu Arg Leu Lys Glu Glu Ile 
            180                 185                 190         


Leu Asn Arg Glu Lys Met Val Asp Ile Leu Ala Gly Pro Asp Ala Tyr 
        195                 200                 205             


Arg Asp Leu Pro Arg Leu Leu Ala Val Ala Glu Ser Gly Gln Gln Ala 
    210                 215                 220                 


Ala Asn Val Leu Leu Ser Leu Asp Glu Thr Tyr Ala Asp Val Met Pro 
225                 230                 235                 240 


Val Gln Thr Ser Ala Ser Ala Thr Ser Ala Phe Val Ser Ile Met Arg 
                245                 250                 255     


Gly Cys Asp Asn Met Cys Ser Tyr Cys Ile Val Pro Phe Thr Arg Gly 
            260                 265                 270         


Arg Glu Arg Ser Arg Pro Ile Ala Ser Ile Leu Glu Glu Val Lys Lys 
        275                 280                 285             


Leu Ser Glu Gln Gly Leu Lys Glu Val Thr Leu Leu Gly Gln Asn Val 
    290                 295                 300                 


Asn Ser Phe Arg Asp Asn Ser Glu Val Gln Phe Asn Ser Ala Val Pro 
305                 310                 315                 320 


Thr Asn Leu Ser Arg Gly Phe Thr Thr Asn Tyr Lys Thr Lys Gln Gly 
                325                 330                 335     


Gly Leu Arg Phe Ala His Leu Leu Asp Gln Val Ser Arg Val Asp Pro 
            340                 345                 350         


Glu Met Arg Ile Arg Phe Thr Ser Pro His Pro Lys Asp Phe Pro Asp 
        355                 360                 365             


Glu Val Leu Gln Leu Ile His Glu Arg Asp Asn Ile Cys Lys Gln Ile 
    370                 375                 380                 


His Leu Pro Ala Gln Ser Gly Ser Ser Arg Val Leu Glu Ala Met Arg 
385                 390                 395                 400 


Arg Gly Tyr Ser Arg Glu Ala Tyr Val Glu Leu Val His His Ile Arg 
                405                 410                 415     


Glu Ser Ile Pro Gly Val Ser Leu Ser Ser Asp Phe Ile Ala Gly Phe 
            420                 425                 430         


Cys Gly Glu Thr Glu Glu Asp His Val Gln Thr Val Ser Leu Leu Arg 
        435                 440                 445             


Glu Val Gln Tyr Asn Met Gly Phe Leu Phe Ala Tyr Ser Met Arg Gln 
    450                 455                 460                 


Thr Arg Ala Tyr His Arg Leu Lys Asp Asp Val Pro Glu Glu Val Lys 
465                 470                 475                 480 


Leu Arg Arg Leu Glu Glu Leu Ile Thr Ile Phe Arg Glu Glu Ala Thr 
                485                 490                 495     


Lys Ala Asn Gln Thr Ser Val Gly Cys Thr Gln Leu Val Leu Val Glu 
            500                 505                 510         


Gly Leu Ser Lys Arg Ser Ala Thr Asp Leu Cys Gly Arg Asn Asp Gly 
        515                 520                 525             


Asn Leu Lys Val Ile Phe Pro Asp Ala Glu Met Glu Asp Val Asn Asn 
    530                 535                 540                 


Pro Gly Leu Arg Val Arg Ala Gln Pro Gly Asp Tyr Val Leu Val Lys 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Ser Gln Thr Leu Arg Gly His Val Leu Cys Arg 
                565                 570                 575     


Thr Thr Leu Arg Asp Ser Ser Ala Tyr Cys 
            580                 585     


<210>  1944
<211>  1814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK5RAP2__Homo_sapiens__NP_001011649

<400>  1944

Met Met Asp Leu Val Leu Glu Glu Asp Val Thr Val Pro Gly Thr Leu 
1               5                   10                  15      


Ser Gly Cys Ser Gly Leu Val Pro Ser Val Pro Asp Asp Leu Asp Gly 
            20                  25                  30          


Ile Asn Pro Asn Ala Gly Leu Gly Asn Gly Leu Leu Pro Asn Val Ser 
        35                  40                  45              


Glu Glu Thr Val Ser Pro Thr Arg Ala Arg Asn Met Lys Asp Phe Glu 
    50                  55                  60                  


Asn Gln Ile Thr Glu Leu Lys Lys Glu Asn Phe Asn Leu Lys Leu Arg 
65                  70                  75                  80  


Ile Tyr Phe Leu Glu Glu Arg Met Gln Gln Glu Phe His Gly Pro Thr 
                85                  90                  95      


Glu His Ile Tyr Lys Thr Asn Ile Glu Leu Lys Val Glu Val Glu Ser 
            100                 105                 110         


Leu Lys Arg Glu Leu Gln Glu Arg Glu Gln Leu Leu Ile Lys Ala Ser 
        115                 120                 125             


Lys Ala Val Glu Ser Leu Ala Glu Ala Gly Gly Ser Glu Ile Gln Arg 
    130                 135                 140                 


Val Lys Glu Asp Ala Arg Lys Lys Val Gln Gln Val Glu Asp Leu Leu 
145                 150                 155                 160 


Thr Lys Arg Ile Leu Leu Leu Glu Lys Asp Val Thr Ala Ala Gln Ala 
                165                 170                 175     


Glu Leu Glu Lys Ala Phe Ala Gly Thr Glu Thr Glu Lys Ala Leu Arg 
            180                 185                 190         


Leu Arg Leu Glu Ser Lys Leu Ser Glu Met Lys Lys Met His Glu Gly 
        195                 200                 205             


Asp Leu Ala Met Ala Leu Val Leu Asp Glu Lys Asp Arg Leu Ile Glu 
    210                 215                 220                 


Glu Leu Lys Leu Ser Leu Lys Ser Lys Glu Ala Leu Ile Gln Cys Leu 
225                 230                 235                 240 


Lys Glu Glu Lys Ser Gln Met Ala Cys Pro Asp Glu Asn Val Ser Ser 
                245                 250                 255     


Gly Glu Leu Arg Gly Leu Cys Ala Ala Pro Arg Glu Glu Lys Glu Arg 
            260                 265                 270         


Glu Thr Glu Ala Ala Gln Met Glu His Gln Lys Glu Arg Asn Ser Phe 
        275                 280                 285             


Glu Glu Arg Ile Gln Ala Leu Glu Glu Asp Leu Arg Glu Lys Glu Arg 
    290                 295                 300                 


Glu Ile Ala Thr Glu Lys Lys Asn Ser Leu Lys Arg Asp Lys Ala Ile 
305                 310                 315                 320 


Gln Gly Leu Thr Met Ala Leu Lys Ser Lys Glu Lys Lys Val Glu Glu 
                325                 330                 335     


Leu Asn Ser Glu Ile Glu Lys Leu Ser Ala Ala Phe Ala Lys Ala Arg 
            340                 345                 350         


Glu Ala Leu Gln Lys Ala Gln Thr Gln Glu Phe Gln Gly Ser Glu Asp 
        355                 360                 365             


Tyr Glu Thr Ala Leu Ser Gly Lys Glu Ala Leu Ser Ala Ala Leu Arg 
    370                 375                 380                 


Ser Gln Asn Leu Thr Lys Ser Thr Glu Asn His Arg Leu Arg Arg Ser 
385                 390                 395                 400 


Ile Lys Lys Ile Thr Gln Glu Leu Ser Asp Leu Gln Gln Glu Arg Glu 
                405                 410                 415     


Arg Leu Glu Lys Asp Leu Glu Glu Ala His Arg Glu Lys Ser Lys Gly 
            420                 425                 430         


Asp Cys Thr Ile Arg Asp Leu Arg Asn Glu Val Glu Lys Leu Arg Asn 
        435                 440                 445             


Glu Val Asn Glu Arg Glu Lys Ala Met Glu Asn Arg Tyr Lys Ser Leu 
    450                 455                 460                 


Leu Ser Glu Ser Asn Lys Lys Leu His Asn Gln Glu Gln Val Ile Lys 
465                 470                 475                 480 


His Leu Thr Glu Ser Thr Asn Gln Lys Asp Val Leu Leu Gln Lys Phe 
                485                 490                 495     


Asn Glu Lys Asp Leu Glu Val Ile Gln Gln Asn Cys Tyr Leu Met Ala 
            500                 505                 510         


Ala Glu Asp Leu Glu Leu Arg Ser Glu Gly Leu Ile Thr Glu Lys Cys 
        515                 520                 525             


Ser Ser Gln Gln Pro Pro Gly Ser Lys Thr Ile Phe Ser Lys Glu Lys 
    530                 535                 540                 


Lys Gln Ser Ser Asp Tyr Glu Glu Leu Ile Gln Val Leu Lys Lys Glu 
545                 550                 555                 560 


Gln Asp Ile Tyr Thr His Leu Val Lys Ser Leu Gln Glu Ser Asp Ser 
                565                 570                 575     


Ile Asn Asn Leu Gln Ala Glu Leu Asn Lys Ile Phe Ala Leu Arg Lys 
            580                 585                 590         


Gln Leu Glu Gln Asp Val Leu Ser Tyr Gln Asn Leu Arg Lys Thr Leu 
        595                 600                 605             


Glu Glu Gln Ile Ser Glu Ile Arg Arg Arg Glu Glu Glu Ser Phe Ser 
    610                 615                 620                 


Leu Tyr Ser Asp Gln Thr Ser Tyr Leu Ser Ile Cys Leu Glu Glu Asn 
625                 630                 635                 640 


Asn Arg Phe Gln Val Glu His Phe Ser Gln Glu Glu Leu Lys Lys Lys 
                645                 650                 655     


Val Ser Asp Leu Ile Gln Leu Val Lys Glu Leu Tyr Thr Asp Asn Gln 
            660                 665                 670         


His Leu Lys Lys Thr Ile Phe Asp Leu Ser Cys Met Gly Phe Gln Gly 
        675                 680                 685             


Asn Gly Phe Pro Asp Arg Leu Ala Ser Thr Glu Gln Thr Glu Leu Leu 
    690                 695                 700                 


Ala Ser Lys Glu Asp Glu Asp Thr Ile Lys Ile Gly Glu Asp Asp Glu 
705                 710                 715                 720 


Ile Asn Phe Leu Ser Asp Gln His Leu Gln Gln Ser Asn Glu Ile Met 
                725                 730                 735     


Lys Asp Leu Ser Lys Gly Gly Cys Lys Asn Gly Tyr Leu Arg His Thr 
            740                 745                 750         


Glu Ser Lys Ile Ser Asp Cys Asp Gly Ala His Ala Pro Gly Cys Leu 
        755                 760                 765             


Glu Glu Gly Ala Phe Ile Asn Leu Leu Ala Pro Leu Phe Asn Glu Lys 
    770                 775                 780                 


Ala Thr Leu Leu Leu Glu Ser Arg Pro Asp Leu Leu Lys Val Val Arg 
785                 790                 795                 800 


Glu Leu Leu Leu Gly Gln Leu Phe Leu Thr Glu Gln Glu Val Ser Gly 
                805                 810                 815     


Glu His Leu Asp Gly Lys Thr Glu Lys Thr Pro Lys Gln Lys Gly Glu 
            820                 825                 830         


Leu Val His Phe Val Gln Thr Asn Ser Phe Ser Lys Pro His Asp Glu 
        835                 840                 845             


Leu Lys Leu Ser Cys Glu Ala Gln Leu Val Lys Ala Gly Glu Val Pro 
    850                 855                 860                 


Lys Val Gly Leu Lys Asp Ala Ser Val Gln Thr Val Ala Thr Glu Gly 
865                 870                 875                 880 


Asp Leu Leu Arg Phe Lys His Glu Ala Thr Arg Glu Ala Trp Glu Glu 
                885                 890                 895     


Lys Pro Ile Asn Thr Ala Leu Ser Ala Glu His Arg Pro Glu Asn Leu 
            900                 905                 910         


His Gly Val Pro Gly Trp Gln Ala Ala Leu Leu Ser Leu Pro Gly Ile 
        915                 920                 925             


Thr Asn Arg Glu Ala Lys Lys Ser Arg Leu Pro Ile Leu Ile Lys Pro 
    930                 935                 940                 


Ser Arg Ser Leu Gly Asn Met Tyr Arg Leu Pro Ala Thr Gln Glu Val 
945                 950                 955                 960 


Val Thr Gln Leu Gln Ser Gln Ile Leu Glu Leu Gln Gly Glu Leu Lys 
                965                 970                 975     


Glu Phe Lys Thr Cys Asn Lys Gln Leu His Gln Lys Leu Ile Leu Ala 
            980                 985                 990         


Glu Ala Val Met Glu Gly Arg Pro  Thr Pro Asp Lys Thr  Leu Leu Asn 
        995                 1000                 1005             


Ala Gln  Pro Pro Val Gly Ala  Ala Tyr Gln Asp Ser  Pro Gly Glu 
    1010                 1015                 1020             


Gln Lys  Gly Ile Lys Thr Thr  Ser Ser Val Trp Arg  Asp Lys Glu 
    1025                 1030                 1035             


Met Asp  Ser Asp Gln Gln Arg  Ser Tyr Glu Ile Asp  Ser Glu Ile 
    1040                 1045                 1050             


Cys Pro  Pro Asp Asp Leu Ala  Ser Leu Pro Ser Cys  Lys Glu Asn 
    1055                 1060                 1065             


Pro Glu  Asp Val Leu Ser Pro  Thr Ser Val Ala Thr  Tyr Leu Ser 
    1070                 1075                 1080             


Ser Lys  Ser Gln Pro Ser Ala  Lys Val Ser Val Met  Gly Thr Asp 
    1085                 1090                 1095             


Gln Ser  Glu Ser Ile Asn Thr  Ser Asn Glu Thr Glu  Tyr Leu Lys 
    1100                 1105                 1110             


Gln Lys  Ile His Asp Leu Glu  Thr Glu Leu Glu Gly  Tyr Gln Asn 
    1115                 1120                 1125             


Phe Ile  Phe Gln Leu Gln Lys  His Ser Gln Cys Ser  Glu Ala Ile 
    1130                 1135                 1140             


Ile Thr  Val Leu Cys Gly Thr  Glu Gly Ala Gln Asp  Gly Leu Ser 
    1145                 1150                 1155             


Lys Pro  Lys Asn Gly Ser Asp  Gly Glu Glu Met Thr  Phe Ser Ser 
    1160                 1165                 1170             


Leu His  Gln Val Arg Tyr Val  Lys His Val Lys Ile  Leu Gly Pro 
    1175                 1180                 1185             


Leu Ala  Pro Glu Met Ile Asp  Ser Arg Val Leu Glu  Asn Leu Lys 
    1190                 1195                 1200             


Gln Gln  Leu Glu Glu Gln Glu  Tyr Lys Leu Gln Lys  Glu Gln Asn 
    1205                 1210                 1215             


Leu Asn  Met Gln Leu Phe Ser  Glu Ile His Asn Leu  Gln Asn Lys 
    1220                 1225                 1230             


Phe Arg  Asp Leu Ser Pro Pro  Arg Tyr Asp Ser Leu  Val Gln Ser 
    1235                 1240                 1245             


Gln Ala  Arg Glu Leu Ser Leu  Gln Arg Gln Gln Ile  Lys Asp Gly 
    1250                 1255                 1260             


His Gly  Ile Cys Val Ile Ser  Arg Gln His Met Asn  Thr Met Ile 
    1265                 1270                 1275             


Lys Ala  Phe Glu Glu Leu Leu  Gln Ala Ser Asp Val  Asp Tyr Cys 
    1280                 1285                 1290             


Val Ala  Glu Gly Phe Gln Glu  Gln Leu Asn Gln Cys  Ala Glu Leu 
    1295                 1300                 1305             


Leu Glu  Lys Leu Glu Lys Leu  Phe Leu Asn Gly Lys  Ser Val Gly 
    1310                 1315                 1320             


Val Glu  Met Asn Thr Gln Asn  Glu Leu Met Glu Arg  Ile Glu Glu 
    1325                 1330                 1335             


Asp Asn  Leu Thr Tyr Gln His  Leu Leu Pro Glu Ser  Pro Glu Pro 
    1340                 1345                 1350             


Ser Ala  Ser His Ala Leu Ser  Asp Tyr Glu Thr Ser  Glu Lys Ser 
    1355                 1360                 1365             


Phe Phe  Ser Arg Asp Gln Lys  Gln Asp Asn Glu Thr  Glu Lys Thr 
    1370                 1375                 1380             


Ser Val  Met Val Asn Ser Phe  Ser Gln Asp Leu Leu  Met Glu His 
    1385                 1390                 1395             


Ile Gln  Glu Ile Arg Thr Leu  Arg Lys Arg Leu Glu  Glu Ser Ile 
    1400                 1405                 1410             


Lys Thr  Asn Glu Lys Leu Arg  Lys Gln Leu Glu Arg  Gln Gly Ser 
    1415                 1420                 1425             


Glu Phe  Val Gln Gly Ser Thr  Ser Ile Phe Ala Ser  Gly Ser Glu 
    1430                 1435                 1440             


Leu His  Ser Ser Leu Thr Ser  Glu Ile His Phe Leu  Arg Lys Gln 
    1445                 1450                 1455             


Asn Gln  Ala Leu Asn Ala Met  Leu Ile Lys Gly Ser  Arg Asp Lys 
    1460                 1465                 1470             


Gln Lys  Glu Asn Asp Lys Leu  Arg Glu Ser Leu Ser  Arg Lys Thr 
    1475                 1480                 1485             


Val Ser  Leu Glu His Leu Gln  Arg Glu Tyr Ala Ser  Val Lys Glu 
    1490                 1495                 1500             


Glu Asn  Glu Arg Leu Gln Lys  Glu Gly Ser Glu Lys  Glu Arg His 
    1505                 1510                 1515             


Asn Gln  Gln Leu Ile Gln Glu  Val Arg Cys Ser Gly  Gln Glu Leu 
    1520                 1525                 1530             


Ser Arg  Val Gln Glu Glu Val  Lys Leu Arg Gln Gln  Leu Leu Ser 
    1535                 1540                 1545             


Gln Asn  Asp Lys Leu Leu Gln  Ser Leu Arg Val Glu  Leu Lys Ala 
    1550                 1555                 1560             


Tyr Glu  Lys Leu Asp Glu Glu  His Arg Arg Leu Arg  Asp Gly Asp 
    1565                 1570                 1575             


Lys Tyr  Pro Met Glu Ser Asp  Asn Ser Phe Asp Leu  Phe Asp Ser 
    1580                 1585                 1590             


Ser Gln  Ala Val Thr Pro Lys  Ser Val Ser Glu Thr  Pro Pro Leu 
    1595                 1600                 1605             


Ser Gly  Asn Asp Thr Asp Ser  Leu Ser Cys Asp Ser  Gly Ser Ser 
    1610                 1615                 1620             


Ala Thr  Ser Thr Pro Cys Val  Ser Arg Leu Val Thr  Gly His His 
    1625                 1630                 1635             


Leu Trp  Ala Ser Lys Asn Gly  Arg His Val Leu Gly  Leu Ile Glu 
    1640                 1645                 1650             


Asp Tyr  Glu Ala Leu Leu Lys  Gln Ile Ser Gln Gly  Gln Arg Leu 
    1655                 1660                 1665             


Leu Ala  Glu Met Asp Ile Gln  Thr Gln Glu Ala Pro  Ser Ser Thr 
    1670                 1675                 1680             


Ser Gln  Glu Leu Gly Thr Lys  Gly Pro His Pro Ala  Pro Leu Ser 
    1685                 1690                 1695             


Lys Phe  Val Ser Ser Val Ser  Thr Ala Lys Leu Thr  Leu Glu Glu 
    1700                 1705                 1710             


Ala Tyr  Arg Arg Leu Lys Leu  Leu Trp Arg Val Ser  Leu Pro Glu 
    1715                 1720                 1725             


Asp Gly  Gln Cys Pro Leu His  Cys Glu Gln Ile Gly  Glu Met Lys 
    1730                 1735                 1740             


Ala Glu  Val Thr Lys Leu His  Lys Lys Leu Phe Glu  Gln Glu Lys 
    1745                 1750                 1755             


Lys Leu  Gln Asn Thr Met Lys  Leu Leu Gln Leu Ser  Lys Arg Gln 
    1760                 1765                 1770             


Glu Lys  Val Ile Phe Asp Gln  Leu Val Val Thr His  Lys Ile Leu 
    1775                 1780                 1785             


Arg Lys  Ala Arg Gly Asn Leu  Glu Leu Arg Pro Gly  Gly Ala His 
    1790                 1795                 1800             


Pro Gly  Thr Cys Ser Pro Ser  Arg Pro Gly Ser 
    1805                 1810                 


<210>  1945
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK5RAP3__Homo_sapiens__NP_788276

<400>  1945

Met Glu Asp His Gln His Val Pro Ile Asp Ile Gln Thr Ser Lys Leu 
1               5                   10                  15      


Leu Asp Trp Leu Val Asp Arg Arg His Cys Ser Leu Lys Trp Gln Ser 
            20                  25                  30          


Leu Val Leu Thr Ile Arg Glu Lys Ile Asn Ala Ala Ile Gln Asp Met 
        35                  40                  45              


Pro Glu Ser Glu Glu Ile Ala Gln Leu Leu Ser Gly Ser Tyr Ile His 
    50                  55                  60                  


Tyr Phe His Cys Leu Arg Ile Leu Asp Leu Leu Lys Gly Thr Glu Ala 
65                  70                  75                  80  


Ser Thr Lys Asn Ile Phe Gly Arg Tyr Ser Ser Gln Arg Met Lys Asp 
                85                  90                  95      


Trp Gln Glu Ile Ile Ala Leu Tyr Glu Lys Asp Asn Thr Tyr Leu Val 
            100                 105                 110         


Glu Leu Ser Ser Leu Leu Val Arg Asn Val Asn Tyr Glu Ile Pro Ser 
        115                 120                 125             


Leu Lys Lys Gln Ile Ala Lys Cys Gln Gln Leu Gln Gln Glu Tyr Ser 
    130                 135                 140                 


Arg Lys Glu Glu Glu Cys Gln Ala Gly Ala Ala Glu Met Arg Glu Gln 
145                 150                 155                 160 


Phe Tyr His Ser Cys Lys Gln Tyr Gly Ile Thr Gly Glu Asn Val Arg 
                165                 170                 175     


Gly Glu Leu Leu Ala Leu Val Lys Asp Leu Pro Ser Gln Leu Ala Glu 
            180                 185                 190         


Ile Gly Ala Ala Ala Gln Gln Ser Leu Gly Glu Ala Ile Asp Val Tyr 
        195                 200                 205             


Gln Ala Ser Val Gly Phe Val Cys Glu Ser Pro Thr Glu Gln Val Leu 
    210                 215                 220                 


Pro Met Leu Arg Phe Val Gln Lys Arg Gly Asn Ser Thr Val Tyr Glu 
225                 230                 235                 240 


Trp Arg Thr Gly Thr Glu Pro Ser Val Val Glu Arg Pro His Leu Glu 
                245                 250                 255     


Glu Leu Pro Glu Gln Val Ala Glu Asp Ala Ile Asp Trp Gly Asp Phe 
            260                 265                 270         


Gly Val Glu Ala Val Ser Glu Gly Thr Asp Ser Gly Ile Ser Ala Glu 
        275                 280                 285             


Ala Ala Gly Ile Asp Trp Gly Ile Phe Pro Glu Ser Asp Ser Lys Asp 
    290                 295                 300                 


Pro Gly Gly Asp Gly Ile Asp Trp Gly Asp Asp Ala Val Ala Leu Gln 
305                 310                 315                 320 


Ile Thr Val Leu Glu Ala Gly Thr Gln Ala Pro Glu Gly Val Ala Arg 
                325                 330                 335     


Gly Pro Asp Ala Leu Thr Leu Leu Glu Tyr Thr Glu Thr Arg Asn Gln 
            340                 345                 350         


Phe Leu Asp Glu Leu Met Glu Leu Glu Ile Phe Leu Ala Gln Arg Ala 
        355                 360                 365             


Val Glu Leu Ser Glu Glu Ala Asp Val Leu Ser Val Ser Gln Phe Gln 
    370                 375                 380                 


Leu Ala Pro Ala Ile Leu Gln Gly Gln Thr Lys Glu Lys Met Val Thr 
385                 390                 395                 400 


Met Val Ser Val Leu Glu Asp Leu Ile Gly Lys Leu Thr Ser Leu Gln 
                405                 410                 415     


Leu Gln His Leu Phe Met Ile Leu Ala Ser Pro Arg Tyr Val Asp Arg 
            420                 425                 430         


Val Thr Glu Phe Leu Gln Gln Lys Leu Lys Gln Ser Gln Leu Leu Ala 
        435                 440                 445             


Leu Lys Lys Glu Leu Met Val Gln Lys Gln Gln Glu Ala Leu Glu Glu 
    450                 455                 460                 


Gln Ala Ala Leu Glu Pro Lys Leu Asp Leu Leu Leu Glu Lys Thr Lys 
465                 470                 475                 480 


Glu Leu Gln Lys Leu Ile Glu Ala Asp Ile Ser Lys Arg Tyr Ser Gly 
                485                 490                 495     


Arg Pro Val Asn Leu Met Gly Thr Ser Leu 
            500                 505     


<210>  1946
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK6__Homo_sapiens__XP_006715898

<400>  1946

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  1947
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK7__Homo_sapiens__NP_001790

<400>  1947

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  1948
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK8__Homo_sapiens__NP_001251

<400>  1948

Met Asp Tyr Asp Phe Lys Val Lys Leu Ser Ser Glu Arg Glu Arg Val 
1               5                   10                  15      


Glu Asp Leu Phe Glu Tyr Glu Gly Cys Lys Val Gly Arg Gly Thr Tyr 
            20                  25                  30          


Gly His Val Tyr Lys Ala Lys Arg Lys Asp Gly Lys Asp Asp Lys Asp 
        35                  40                  45              


Tyr Ala Leu Lys Gln Ile Glu Gly Thr Gly Ile Ser Met Ser Ala Cys 
    50                  55                  60                  


Arg Glu Ile Ala Leu Leu Arg Glu Leu Lys His Pro Asn Val Ile Ser 
65                  70                  75                  80  


Leu Gln Lys Val Phe Leu Ser His Ala Asp Arg Lys Val Trp Leu Leu 
                85                  90                  95      


Phe Asp Tyr Ala Glu His Asp Leu Trp His Ile Ile Lys Phe His Arg 
            100                 105                 110         


Ala Ser Lys Ala Asn Lys Lys Pro Val Gln Leu Pro Arg Gly Met Val 
        115                 120                 125             


Lys Ser Leu Leu Tyr Gln Ile Leu Asp Gly Ile His Tyr Leu His Ala 
    130                 135                 140                 


Asn Trp Val Leu His Arg Asp Leu Lys Pro Ala Asn Ile Leu Val Met 
145                 150                 155                 160 


Gly Glu Gly Pro Glu Arg Gly Arg Val Lys Ile Ala Asp Met Gly Phe 
                165                 170                 175     


Ala Arg Leu Phe Asn Ser Pro Leu Lys Pro Leu Ala Asp Leu Asp Pro 
            180                 185                 190         


Val Val Val Thr Phe Trp Tyr Arg Ala Pro Glu Leu Leu Leu Gly Ala 
        195                 200                 205             


Arg His Tyr Thr Lys Ala Ile Asp Ile Trp Ala Ile Gly Cys Ile Phe 
    210                 215                 220                 


Ala Glu Leu Leu Thr Ser Glu Pro Ile Phe His Cys Arg Gln Glu Asp 
225                 230                 235                 240 


Ile Lys Thr Ser Asn Pro Tyr His His Asp Gln Leu Asp Arg Ile Phe 
                245                 250                 255     


Asn Val Met Gly Phe Pro Ala Asp Lys Asp Trp Glu Asp Ile Lys Lys 
            260                 265                 270         


Met Pro Glu His Ser Thr Leu Met Lys Asp Phe Arg Arg Asn Thr Tyr 
        275                 280                 285             


Thr Asn Cys Ser Leu Ile Lys Tyr Met Glu Lys His Lys Val Lys Pro 
    290                 295                 300                 


Asp Ser Lys Ala Phe His Leu Leu Gln Lys Leu Leu Thr Met Asp Pro 
305                 310                 315                 320 


Ile Lys Arg Ile Thr Ser Glu Gln Ala Met Gln Asp Pro Tyr Phe Leu 
                325                 330                 335     


Glu Asp Pro Leu Pro Thr Ser Asp Val Phe Ala Gly Cys Gln Ile Pro 
            340                 345                 350         


Tyr Pro Lys Arg Glu Phe Leu Thr Glu Glu Glu Pro Asp Asp Lys Gly 
        355                 360                 365             


Asp Lys Lys Asn Gln Gln Gln Gln Gln Gly Asn Asn His Thr Asn Gly 
    370                 375                 380                 


Thr Gly His Pro Gly Asn Gln Asp Ser Ser His Thr Gln Gly Pro Pro 
385                 390                 395                 400 


Leu Lys Lys Val Arg Val Val Pro Pro Thr Thr Thr Ser Gly Gly Leu 
                405                 410                 415     


Ile Met Thr Ser Asp Tyr Gln Arg Ser Asn Pro His Ala Ala Tyr Pro 
            420                 425                 430         


Asn Pro Gly Pro Ser Thr Ser Gln Pro Gln Ser Ser Met Gly Tyr Ser 
        435                 440                 445             


Ala Thr Ser Gln Gln Pro Pro Gln Tyr Ser His Gln Thr His Arg Tyr 
    450                 455                 460                 


<210>  1949
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDK9__Homo_sapiens__NP_001252

<400>  1949

Met Ala Lys Gln Tyr Asp Ser Val Glu Cys Pro Phe Cys Asp Glu Val 
1               5                   10                  15      


Ser Lys Tyr Glu Lys Leu Ala Lys Ile Gly Gln Gly Thr Phe Gly Glu 
            20                  25                  30          


Val Phe Lys Ala Arg His Arg Lys Thr Gly Gln Lys Val Ala Leu Lys 
        35                  40                  45              


Lys Val Leu Met Glu Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Leu 
    50                  55                  60                  


Arg Glu Ile Lys Ile Leu Gln Leu Leu Lys His Glu Asn Val Val Asn 
65                  70                  75                  80  


Leu Ile Glu Ile Cys Arg Thr Lys Ala Ser Pro Tyr Asn Arg Cys Lys 
                85                  90                  95      


Gly Ser Ile Tyr Leu Val Phe Asp Phe Cys Glu His Asp Leu Ala Gly 
            100                 105                 110         


Leu Leu Ser Asn Val Leu Val Lys Phe Thr Leu Ser Glu Ile Lys Arg 
        115                 120                 125             


Val Met Gln Met Leu Leu Asn Gly Leu Tyr Tyr Ile His Arg Asn Lys 
    130                 135                 140                 


Ile Leu His Arg Asp Met Lys Ala Ala Asn Val Leu Ile Thr Arg Asp 
145                 150                 155                 160 


Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Phe Ser Leu 
                165                 170                 175     


Ala Lys Asn Ser Gln Pro Asn Arg Tyr Thr Asn Arg Val Val Thr Leu 
            180                 185                 190         


Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Arg Asp Tyr Gly Pro 
        195                 200                 205             


Pro Ile Asp Leu Trp Gly Ala Gly Cys Ile Met Ala Glu Met Trp Thr 
    210                 215                 220                 


Arg Ser Pro Ile Met Gln Gly Asn Thr Glu Gln His Gln Leu Ala Leu 
225                 230                 235                 240 


Ile Ser Gln Leu Cys Gly Ser Ile Thr Pro Glu Val Trp Pro Asn Val 
                245                 250                 255     


Asp Asn Tyr Glu Leu Tyr Glu Lys Leu Glu Leu Val Lys Gly Gln Lys 
            260                 265                 270         


Arg Lys Val Lys Asp Arg Leu Lys Ala Tyr Val Arg Asp Pro Tyr Ala 
        275                 280                 285             


Leu Asp Leu Ile Asp Lys Leu Leu Val Leu Asp Pro Ala Gln Arg Ile 
    290                 295                 300                 


Asp Ser Asp Asp Ala Leu Asn His Asp Phe Phe Trp Ser Asp Pro Met 
305                 310                 315                 320 


Pro Ser Asp Leu Lys Gly Met Leu Ser Thr His Leu Thr Ser Met Phe 
                325                 330                 335     


Glu Tyr Leu Ala Pro Pro Arg Arg Lys Gly Ser Gln Ile Thr Gln Gln 
            340                 345                 350         


Ser Thr Asn Gln Ser Arg Asn Pro Ala Thr Thr Asn Gln Thr Glu Phe 
        355                 360                 365             


Glu Arg Val Phe 
    370         


<210>  1950
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKAL1__Homo_sapiens__NP_060244

<400>  1950

Met Pro Ser Ala Ser Cys Asp Thr Leu Leu Asp Asp Ile Glu Asp Ile 
1               5                   10                  15      


Val Ser Gln Glu Asp Ser Lys Pro Gln Asp Arg His Phe Val Arg Lys 
            20                  25                  30          


Asp Val Val Pro Lys Val Arg Arg Arg Asn Thr Gln Lys Tyr Leu Gln 
        35                  40                  45              


Glu Glu Glu Asn Ser Pro Pro Ser Asp Ser Thr Ile Pro Gly Ile Gln 
    50                  55                  60                  


Lys Ile Trp Ile Arg Thr Trp Gly Cys Ser His Asn Asn Ser Asp Gly 
65                  70                  75                  80  


Glu Tyr Met Ala Gly Gln Leu Ala Ala Tyr Gly Tyr Lys Ile Thr Glu 
                85                  90                  95      


Asn Ala Ser Asp Ala Asp Leu Trp Leu Leu Asn Ser Cys Thr Val Lys 
            100                 105                 110         


Asn Pro Ala Glu Asp His Phe Arg Asn Ser Ile Lys Lys Ala Gln Glu 
        115                 120                 125             


Glu Asn Lys Lys Ile Val Leu Ala Gly Cys Val Pro Gln Ala Gln Pro 
    130                 135                 140                 


Arg Gln Asp Tyr Leu Lys Gly Leu Ser Ile Ile Gly Val Gln Gln Ile 
145                 150                 155                 160 


Asp Arg Val Val Glu Val Val Glu Glu Thr Ile Lys Gly His Ser Val 
                165                 170                 175     


Arg Leu Leu Gly Gln Lys Lys Asp Asn Gly Arg Arg Leu Gly Gly Ala 
            180                 185                 190         


Arg Leu Asp Leu Pro Lys Ile Arg Lys Asn Pro Leu Ile Glu Ile Ile 
        195                 200                 205             


Ser Ile Asn Thr Gly Cys Leu Asn Ala Cys Thr Tyr Cys Lys Thr Lys 
    210                 215                 220                 


His Ala Arg Gly Asn Leu Ala Ser Tyr Pro Ile Asp Glu Leu Val Asp 
225                 230                 235                 240 


Arg Ala Lys Gln Ser Phe Gln Glu Gly Val Cys Glu Ile Trp Leu Thr 
                245                 250                 255     


Ser Glu Asp Thr Gly Ala Tyr Gly Arg Asp Ile Gly Thr Asn Leu Pro 
            260                 265                 270         


Thr Leu Leu Trp Lys Leu Val Glu Val Ile Pro Glu Gly Ala Met Leu 
        275                 280                 285             


Arg Leu Gly Met Thr Asn Pro Pro Tyr Ile Leu Glu His Leu Glu Glu 
    290                 295                 300                 


Met Ala Lys Ile Leu Asn His Pro Arg Val Tyr Ala Phe Leu His Ile 
305                 310                 315                 320 


Pro Val Gln Ser Ala Ser Asp Ser Val Leu Met Glu Met Lys Arg Glu 
                325                 330                 335     


Tyr Cys Val Ala Asp Phe Lys Arg Val Val Asp Phe Leu Lys Glu Lys 
            340                 345                 350         


Val Pro Gly Ile Thr Ile Ala Thr Asp Ile Ile Cys Gly Phe Pro Gly 
        355                 360                 365             


Glu Thr Asp Gln Asp Phe Gln Glu Thr Val Lys Leu Val Glu Glu Tyr 
    370                 375                 380                 


Lys Phe Pro Ser Leu Phe Ile Asn Gln Phe Tyr Pro Arg Pro Gly Thr 
385                 390                 395                 400 


Pro Ala Ala Lys Met Glu Gln Val Pro Ala Gln Val Lys Lys Gln Arg 
                405                 410                 415     


Thr Lys Asp Leu Ser Arg Val Phe His Ser Tyr Ser Pro Tyr Asp His 
            420                 425                 430         


Lys Ile Gly Glu Arg Gln Gln Val Leu Val Thr Glu Glu Ser Phe Asp 
        435                 440                 445             


Ser Lys Phe Tyr Val Ala His Asn Gln Phe Tyr Glu Gln Val Leu Val 
    450                 455                 460                 


Pro Lys Asn Pro Ala Phe Met Gly Lys Met Val Glu Val Asp Ile Tyr 
465                 470                 475                 480 


Glu Ser Gly Lys His Phe Met Lys Gly Gln Pro Val Ser Asp Ala Lys 
                485                 490                 495     


Val Tyr Thr Pro Ser Ile Ser Lys Pro Leu Ala Lys Gly Glu Val Ser 
            500                 505                 510         


Gly Leu Thr Lys Asp Phe Arg Asn Gly Leu Gly Asn Gln Leu Ser Ser 
        515                 520                 525             


Gly Ser His Thr Ser Ala Ala Ser Gln Cys Asp Ser Ala Ser Ser Arg 
    530                 535                 540                 


Met Val Leu Pro Met Pro Arg Leu His Gln Asp Cys Ala Leu Arg Met 
545                 550                 555                 560 


Ser Val Gly Leu Ala Leu Leu Gly Leu Leu Phe Ala Phe Phe Val Lys 
                565                 570                 575     


Val Tyr Asn 
            


<210>  1951
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL1__Homo_sapiens__NP_004187

<400>  1951

Met Met Glu Lys Tyr Glu Lys Ile Gly Lys Ile Gly Glu Gly Ser Tyr 
1               5                   10                  15      


Gly Val Val Phe Lys Cys Arg Asn Arg Asp Thr Gly Gln Ile Val Ala 
            20                  25                  30          


Ile Lys Lys Phe Leu Glu Ser Glu Asp Asp Pro Val Ile Lys Lys Ile 
        35                  40                  45              


Ala Leu Arg Glu Ile Arg Met Leu Lys Gln Leu Lys His Pro Asn Leu 
    50                  55                  60                  


Val Asn Leu Leu Glu Val Phe Arg Arg Lys Arg Arg Leu His Leu Val 
65                  70                  75                  80  


Phe Glu Tyr Cys Asp His Thr Val Leu His Glu Leu Asp Arg Tyr Gln 
                85                  90                  95      


Arg Gly Val Pro Glu His Leu Val Lys Ser Ile Thr Trp Gln Thr Leu 
            100                 105                 110         


Gln Ala Val Asn Phe Cys His Lys His Asn Cys Ile His Arg Asp Val 
        115                 120                 125             


Lys Pro Glu Asn Ile Leu Ile Thr Lys His Ser Val Ile Lys Leu Cys 
    130                 135                 140                 


Asp Phe Gly Phe Ala Arg Leu Leu Thr Gly Pro Ser Asp Tyr Tyr Thr 
145                 150                 155                 160 


Asp Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu Val Gly 
                165                 170                 175     


Asp Thr Gln Tyr Gly Pro Pro Val Asp Val Trp Ala Ile Gly Cys Val 
            180                 185                 190         


Phe Ala Glu Leu Leu Ser Gly Val Pro Leu Trp Pro Gly Lys Ser Asp 
        195                 200                 205             


Val Asp Gln Leu Tyr Leu Ile Arg Lys Thr Leu Gly Asp Leu Ile Pro 
    210                 215                 220                 


Arg His Gln Gln Val Phe Ser Thr Asn Gln Tyr Phe Ser Gly Val Lys 
225                 230                 235                 240 


Ile Pro Asp Pro Glu Asp Met Glu Pro Leu Glu Leu Lys Phe Pro Asn 
                245                 250                 255     


Ile Ser Tyr Pro Ala Leu Gly Leu Leu Lys Gly Cys Leu His Met Asp 
            260                 265                 270         


Pro Thr Gln Arg Leu Thr Cys Glu Gln Leu Leu His His Pro Tyr Phe 
        275                 280                 285             


Glu Asn Ile Arg Glu Ile Glu Asp Leu Ala Lys Glu His Asn Lys Pro 
    290                 295                 300                 


Thr Arg Lys Thr Leu Arg Lys Ser Arg Lys His His Cys Phe Thr Glu 
305                 310                 315                 320 


Thr Ser Lys Leu Gln Tyr Leu Pro Gln Leu Thr Gly Ser Ser Ile Leu 
                325                 330                 335     


Pro Ala Leu Asp Asn Lys Lys Tyr Tyr Cys Asp Thr Lys Lys Leu Asn 
            340                 345                 350         


Tyr Arg Phe Pro Asn Ile 
        355             


<210>  1952
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL2__Homo_sapiens__NP_003939

<400>  1952

Met Glu Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Met Val Met Lys Cys Arg Asn Lys Asp Thr Gly Arg Ile Val Ala Ile 
            20                  25                  30          


Lys Lys Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala 
        35                  40                  45              


Met Arg Glu Ile Lys Leu Leu Lys Gln Leu Arg His Glu Asn Leu Val 
    50                  55                  60                  


Asn Leu Leu Glu Val Cys Lys Lys Lys Lys Arg Trp Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Val Asp His Thr Ile Leu Asp Asp Leu Glu Leu Phe Pro Asn 
                85                  90                  95      


Gly Leu Asp Tyr Gln Val Val Gln Lys Tyr Leu Phe Gln Ile Ile Asn 
            100                 105                 110         


Gly Ile Gly Phe Cys His Ser His Asn Ile Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Val Ser Gln Ser Gly Val Val Lys Leu Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Glu Val Tyr Thr Asp 
145                 150                 155                 160 


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp 
                165                 170                 175     


Val Lys Tyr Gly Lys Ala Val Asp Val Trp Ala Ile Gly Cys Leu Val 
            180                 185                 190         


Thr Glu Met Phe Met Gly Glu Pro Leu Phe Pro Gly Asp Ser Asp Ile 
        195                 200                 205             


Asp Gln Leu Tyr His Ile Met Met Cys Leu Gly Asn Leu Ile Pro Arg 
    210                 215                 220                 


His Gln Glu Leu Phe Asn Lys Asn Pro Val Phe Ala Gly Val Arg Leu 
225                 230                 235                 240 


Pro Glu Ile Lys Glu Arg Glu Pro Leu Glu Arg Arg Tyr Pro Lys Leu 
                245                 250                 255     


Ser Glu Val Val Ile Asp Leu Ala Lys Lys Cys Leu His Ile Asp Pro 
            260                 265                 270         


Asp Lys Arg Pro Phe Cys Ala Glu Leu Leu His His Asp Phe Phe Gln 
        275                 280                 285             


Met Asp Gly Phe Ala Glu Arg Phe Ser Gln Glu Leu Gln Leu Lys Val 
    290                 295                 300                 


Gln Lys Asp Ala Arg Asn Val Ser Leu Ser Lys Lys Ser Gln Asn Arg 
305                 310                 315                 320 


Lys Lys Glu Lys Glu Lys Asp Asp Ser Leu Val Glu Glu Arg Lys Thr 
                325                 330                 335     


Leu Val Val Gln Asp Thr Asn Ala Asp Pro Lys Ile Lys Asp Tyr Lys 
            340                 345                 350         


Leu Phe Lys Ile Lys Gly Ser Lys Ile Asp Gly Glu Lys Ala Glu Lys 
        355                 360                 365             


Gly Asn Arg Ala Ser Asn Ala Ser Cys Leu His Asp Ser Arg Thr Ser 
    370                 375                 380                 


His Asn Lys Ile Val Pro Ser Thr Ser Leu Lys Asp Cys Ser Asn Val 
385                 390                 395                 400 


Ser Val Asp His Thr Arg Asn Pro Ser Val Ala Ile Pro Pro Leu Thr 
                405                 410                 415     


His Asn Leu Ser Ala Val Ala Pro Ser Ile Asn Ser Gly Met Gly Thr 
            420                 425                 430         


Glu Thr Ile Pro Ile Gln Gly Tyr Arg Val Asp Glu Lys Thr Lys Lys 
        435                 440                 445             


Cys Ser Ile Pro Phe Val Lys Pro Asn Arg His Ser Pro Ser Gly Ile 
    450                 455                 460                 


Tyr Asn Ile Asn Val Thr Thr Leu Val Ser Gly Pro Pro Leu Ser Asp 
465                 470                 475                 480 


Asp Ser Gly Ala Asp Leu Pro Gln Met Glu His Gln His 
                485                 490             


<210>  1953
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL3__Homo_sapiens__NP_001107047

<400>  1953

Met Glu Met Tyr Glu Thr Leu Gly Lys Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Thr Val Met Lys Cys Lys His Lys Asn Thr Gly Gln Ile Val Ala Ile 
            20                  25                  30          


Lys Ile Phe Tyr Glu Arg Pro Glu Gln Ser Val Asn Lys Ile Ala Met 
        35                  40                  45              


Arg Glu Ile Lys Phe Leu Lys Gln Phe His His Glu Asn Leu Val Asn 
    50                  55                  60                  


Leu Ile Glu Val Phe Arg Gln Lys Lys Lys Ile His Leu Val Phe Glu 
65                  70                  75                  80  


Phe Ile Asp His Thr Val Leu Asp Glu Leu Gln His Tyr Cys His Gly 
                85                  90                  95      


Leu Glu Ser Lys Arg Leu Arg Lys Tyr Leu Phe Gln Ile Leu Arg Ala 
            100                 105                 110         


Ile Asp Tyr Leu His Ser Asn Asn Ile Ile His Arg Asp Ile Lys Pro 
        115                 120                 125             


Glu Asn Ile Leu Val Ser Gln Ser Gly Ile Thr Lys Leu Cys Asp Phe 
    130                 135                 140                 


Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Asp Ile Tyr Thr Asp Tyr 
145                 150                 155                 160 


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Val Leu Lys Asp Thr 
                165                 170                 175     


Ser Tyr Gly Lys Pro Val Asp Ile Trp Ala Leu Gly Cys Met Ile Ile 
            180                 185                 190         


Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser Asp Leu Asp 
        195                 200                 205             


Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser Pro His Leu 
    210                 215                 220                 


Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val Val Leu Pro 
225                 230                 235                 240 


Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro Lys Leu Asn 
                245                 250                 255     


Gly Leu Leu Ala Asp Ile Val His Ala Cys Leu Gln Ile Asp Pro Ala 
            260                 265                 270         


Asp Arg Ile Ser Ser Ser Asp Leu Leu His His Glu Tyr Phe Thr Arg 
        275                 280                 285             


Asp Gly Phe Ile Glu Lys Phe Met Pro Glu Leu Lys Ala Lys Leu Leu 
    290                 295                 300                 


Gln Glu Ala Lys Val Asn Ser Leu Ile Lys Pro Lys Glu Ser Ser Lys 
305                 310                 315                 320 


Glu Asn Glu Leu Arg Lys Asp Glu Arg Lys Thr Val Tyr Thr Asn Thr 
                325                 330                 335     


Leu Leu Ser Ser Ser Val Leu Gly Lys Glu Ile Glu Lys Glu Lys Lys 
            340                 345                 350         


Pro Lys Glu Ile Lys Val Arg Val Ile Lys Val Lys Gly Gly Arg Gly 
        355                 360                 365             


Asp Ile Ser Glu Pro Lys Lys Lys Glu Tyr Glu Gly Gly Leu Gly Gln 
    370                 375                 380                 


Gln Asp Ala Asn Glu Asn Val His Pro Met Ser Pro Asp Thr Lys Leu 
385                 390                 395                 400 


Val Thr Ile Glu Pro Pro Asn Pro Ile Asn Pro Ser Thr Asn Cys Asn 
                405                 410                 415     


Gly Leu Lys Glu Asn Pro His Cys Gly Gly Ser Val Thr Met Pro Pro 
            420                 425                 430         


Ile Asn Leu Thr Asn Ser Asn Leu Met Ala Ala Asn Leu Ser Ser Asn 
        435                 440                 445             


Leu Phe His Pro Ser Val Arg Leu Thr Glu Arg Ala Lys Lys Arg Arg 
    450                 455                 460                 


Thr Ser Ser Gln Ser Ile Gly Gln Val Met Pro Asn Ser Arg Gln Glu 
465                 470                 475                 480 


Asp Pro Gly Pro Ile Gln Ser Gln Met Glu Lys Gly Ile Phe Asn Glu 
                485                 490                 495     


Arg Thr Gly His Ser Asp Gln Met Ala Asn Glu Asn Lys Arg Lys Leu 
            500                 505                 510         


Asn Phe Ser Arg Ser Asp Arg Lys Glu Phe His Phe Pro Glu Leu Pro 
        515                 520                 525             


Val Thr Ile Gln Ser Lys Asp Thr Lys Gly Met Glu Val Lys Gln Ile 
    530                 535                 540                 


Lys Met Leu Lys Arg Glu Ser Lys Lys Thr Glu Ser Ser Lys Ile Pro 
545                 550                 555                 560 


Thr Leu Leu Asn Val Asp Gln Asn Gln Glu Lys Gln Glu Gly Gly Asp 
                565                 570                 575     


Gly His Cys Glu Gly Lys Asn Leu Lys Arg Asn Arg Phe Phe Phe Trp 
            580                 585                 590         


<210>  1954
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL4__Homo_sapiens__NP_001009565

<400>  1954

Met Glu Lys Tyr Glu Lys Leu Ala Lys Thr Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Val Val Phe Lys Cys Arg Asn Lys Thr Ser Gly Gln Val Val Ala Val 
            20                  25                  30          


Lys Lys Phe Val Glu Ser Glu Asp Asp Pro Val Val Lys Lys Ile Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Met Leu Lys Gln Leu Lys His Pro Asn Leu Val 
    50                  55                  60                  


Asn Leu Ile Glu Val Phe Arg Arg Lys Arg Lys Met His Leu Val Phe 
65                  70                  75                  80  


Glu Tyr Cys Asp His Thr Leu Leu Asn Glu Leu Glu Arg Asn Pro Asn 
                85                  90                  95      


Gly Val Ala Asp Gly Val Ile Lys Ser Val Leu Trp Gln Thr Leu Gln 
            100                 105                 110         


Ala Leu Asn Phe Cys His Ile His Asn Cys Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Ile Thr Lys Gln Gly Ile Ile Lys Ile Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Gln Ile Leu Ile Pro Gly Asp Ala Tyr Thr Asp Tyr 
145                 150                 155                 160 


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp Thr 
                165                 170                 175     


Gln Tyr Gly Ser Ser Val Asp Ile Trp Ala Ile Gly Cys Val Phe Ala 
            180                 185                 190         


Glu Leu Leu Thr Gly Gln Pro Leu Trp Pro Gly Lys Ser Asp Val Asp 
        195                 200                 205             


Gln Leu Tyr Leu Ile Ile Arg Thr Leu Gly Lys Leu Ile Pro Arg His 
    210                 215                 220                 


Gln Ser Ile Phe Lys Ser Asn Gly Phe Phe His Gly Ile Ser Ile Pro 
225                 230                 235                 240 


Glu Pro Glu Asp Met Glu Thr Leu Glu Glu Lys Phe Ser Asp Val His 
                245                 250                 255     


Pro Val Ala Leu Asn Phe Met Lys Gly Cys Leu Lys Met Asn Pro Asp 
            260                 265                 270         


Asp Arg Leu Thr Cys Ser Gln Leu Leu Glu Ser Ser Tyr Phe Asp Ser 
        275                 280                 285             


Phe Gln Glu Ala Gln Ile Lys Arg Lys Ala Arg Asn Glu Gly Arg Asn 
    290                 295                 300                 


Arg Arg Arg Gln Gln Val Leu Pro Leu Lys Ser 
305                 310                 315 


<210>  1955
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL5__Homo_sapiens__NP_001032420

<400>  1955

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg Arg 
            900                 905                 910         


Gln Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg Thr 
        915                 920                 925             


Thr Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys Pro 
    930                 935                 940                 


His Thr Pro Cys Val Pro Asn Arg Ala Leu His Arg Pro Ile Ser Ser 
945                 950                 955                 960 


Pro Ala Pro Tyr Pro Val Leu Gln Val Arg Gly Thr Ser Met Cys Pro 
                965                 970                 975     


Thr Leu Gln Val Arg Gly Thr Asp Ala Phe Ser Cys Pro Thr Gln Gln 
            980                 985                 990         


Ser Gly Phe Ser Phe Phe Val Arg  His Val Met Arg Glu  Ala Leu Ile 
        995                 1000                 1005             


His Arg  Ala Gln Val Asn Gln  Ala Ala Leu Leu Thr  Tyr His Glu 
    1010                 1015                 1020             


Asn Ala  Ala Leu Thr Gly Lys  
    1025                 1030 


<210>  1956
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN1A__Homo_sapiens__NP_000380

<400>  1956

Met Ser Glu Pro Ala Gly Asp Val Arg Gln Asn Pro Cys Gly Ser Lys 
1               5                   10                  15      


Ala Cys Arg Arg Leu Phe Gly Pro Val Asp Ser Glu Gln Leu Ser Arg 
            20                  25                  30          


Asp Cys Asp Ala Leu Met Ala Gly Cys Ile Gln Glu Ala Arg Glu Arg 
        35                  40                  45              


Trp Asn Phe Asp Phe Val Thr Glu Thr Pro Leu Glu Gly Asp Phe Ala 
    50                  55                  60                  


Trp Glu Arg Val Arg Gly Leu Gly Leu Pro Lys Leu Tyr Leu Pro Thr 
65                  70                  75                  80  


Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly Gly Arg Arg Pro Gly 
                85                  90                  95      


Thr Ser Pro Ala Leu Leu Gln Gly Thr Ala Glu Glu Asp His Val Asp 
            100                 105                 110         


Leu Ser Leu Ser Cys Thr Leu Val Pro Arg Ser Gly Glu Gln Ala Glu 
        115                 120                 125             


Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly Arg Lys Arg Arg Gln 
    130                 135                 140                 


Thr Ser Met Thr Asp Phe Tyr His Ser Lys Arg Arg Leu Ile Phe Ser 
145                 150                 155                 160 


Lys Arg Lys Pro 
                


<210>  1957
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN1B__Homo_sapiens__NP_004055

<400>  1957

Met Ser Asn Val Arg Val Ser Asn Gly Ser Pro Ser Leu Glu Arg Met 
1               5                   10                  15      


Asp Ala Arg Gln Ala Glu His Pro Lys Pro Ser Ala Cys Arg Asn Leu 
            20                  25                  30          


Phe Gly Pro Val Asp His Glu Glu Leu Thr Arg Asp Leu Glu Lys His 
        35                  40                  45              


Cys Arg Asp Met Glu Glu Ala Ser Gln Arg Lys Trp Asn Phe Asp Phe 
    50                  55                  60                  


Gln Asn His Lys Pro Leu Glu Gly Lys Tyr Glu Trp Gln Glu Val Glu 
65                  70                  75                  80  


Lys Gly Ser Leu Pro Glu Phe Tyr Tyr Arg Pro Pro Arg Pro Pro Lys 
                85                  90                  95      


Gly Ala Cys Lys Val Pro Ala Gln Glu Ser Gln Asp Val Ser Gly Ser 
            100                 105                 110         


Arg Pro Ala Ala Pro Leu Ile Gly Ala Pro Ala Asn Ser Glu Asp Thr 
        115                 120                 125             


His Leu Val Asp Pro Lys Thr Asp Pro Ser Asp Ser Gln Thr Gly Leu 
    130                 135                 140                 


Ala Glu Gln Cys Ala Gly Ile Arg Lys Arg Pro Ala Thr Asp Asp Ser 
145                 150                 155                 160 


Ser Thr Gln Asn Lys Arg Ala Asn Arg Thr Glu Glu Asn Val Ser Asp 
                165                 170                 175     


Gly Ser Pro Asn Ala Gly Ser Val Glu Gln Thr Pro Lys Lys Pro Gly 
            180                 185                 190         


Leu Arg Arg Arg Gln Thr 
        195             


<210>  1958
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN1C__Homo_sapiens__NP_000067

<400>  1958

Met Ser Asp Ala Ser Leu Arg Ser Thr Ser Thr Met Glu Arg Leu Val 
1               5                   10                  15      


Ala Arg Gly Thr Phe Pro Val Leu Val Arg Thr Ser Ala Cys Arg Ser 
            20                  25                  30          


Leu Phe Gly Pro Val Asp His Glu Glu Leu Ser Arg Glu Leu Gln Ala 
        35                  40                  45              


Arg Leu Ala Glu Leu Asn Ala Glu Asp Gln Asn Arg Trp Asp Tyr Asp 
    50                  55                  60                  


Phe Gln Gln Asp Met Pro Leu Arg Gly Pro Gly Arg Leu Gln Trp Thr 
65                  70                  75                  80  


Glu Val Asp Ser Asp Ser Val Pro Ala Phe Tyr Arg Glu Thr Val Gln 
                85                  90                  95      


Val Gly Arg Cys Arg Leu Leu Leu Ala Pro Arg Pro Val Ala Val Ala 
            100                 105                 110         


Val Ala Val Ser Pro Pro Leu Glu Pro Ala Ala Glu Ser Leu Asp Gly 
        115                 120                 125             


Leu Glu Glu Ala Pro Glu Gln Leu Pro Ser Val Pro Val Pro Ala Pro 
    130                 135                 140                 


Ala Ser Thr Pro Pro Pro Val Pro Val Leu Ala Pro Ala Pro Ala Pro 
145                 150                 155                 160 


Ala Pro Ala Pro Val Ala Ala Pro Val Ala Ala Pro Val Ala Val Ala 
                165                 170                 175     


Val Leu Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            180                 185                 190         


Ala Pro Val Ala Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
        195                 200                 205             


Ala Pro Ala Pro Ala Pro Ala Pro Asp Ala Ala Pro Gln Glu Ser Ala 
    210                 215                 220                 


Glu Gln Gly Ala Asn Gln Gly Gln Arg Gly Gln Glu Pro Leu Ala Asp 
225                 230                 235                 240 


Gln Leu His Ser Gly Ile Ser Gly Arg Pro Ala Ala Gly Thr Ala Ala 
                245                 250                 255     


Ala Ser Ala Asn Gly Ala Ala Ile Lys Lys Leu Ser Gly Pro Leu Ile 
            260                 265                 270         


Ser Asp Phe Phe Ala Lys Arg Lys Arg Ser Ala Pro Glu Lys Ser Ser 
        275                 280                 285             


Gly Asp Val Pro Ala Pro Cys Pro Ser Pro Ser Ala Ala Pro Gly Val 
    290                 295                 300                 


Gly Ser Val Glu Gln Thr Pro Arg Lys Arg Leu Arg 
305                 310                 315     


<210>  1959
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN2A__Homo_sapiens__NP_000068

<400>  1959

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210>  1960
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN2AIP__Homo_sapiens__NP_060102

<400>  1960

Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Thr Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Thr Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Thr Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Thr Asp Ala 
            100                 105                 110         


Pro Thr Tyr Thr Thr Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 
        115                 120                 125             


Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 
    130                 135                 140                 


Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 
145                 150                 155                 160 


Thr Ser Ala Lys Thr Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 
                165                 170                 175     


Thr Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 
            180                 185                 190         


Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Thr Ser Asp Gly Asp Arg 
        195                 200                 205             


Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Thr Thr 
    210                 215                 220                 


Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 
225                 230                 235                 240 


Ser Ala Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met 
                245                 250                 255     


Thr Gln Ser Thr Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser 
            260                 265                 270         


Ala Leu Glu Gly Ser Ser Ala Ser Ala Ser Gln Ser Ser Ser Glu Ile 
        275                 280                 285             


Glu Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro 
    290                 295                 300                 


Leu Leu Ser Ser Lys Pro Ser Ser Glu Thr Ala Ser Ser Gly Leu Thr 
305                 310                 315                 320 


Ser Lys Thr Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn 
                325                 330                 335     


Ser Ser Ser Ser Gly Thr Ser Leu Leu Thr Pro Lys Ser Ser Ser Ser 
            340                 345                 350         


Thr Asn Thr Ser Leu Leu Thr Ser Lys Ser Thr Ser Gln Val Ala Ala 
        355                 360                 365             


Ser Leu Leu Ala Ser Lys Ser Ser Ser Gln Thr Ser Gly Ser Leu Val 
    370                 375                 380                 


Ser Lys Ser Thr Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser 
385                 390                 395                 400 


Ser Ser Gln Thr Ser Thr Ser Gln Leu Pro Ser Lys Ser Thr Ser Gln 
                405                 410                 415     


Ser Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Thr Asn Glu Asp 
            420                 425                 430         


Val Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Thr Val Ala 
        435                 440                 445             


Trp Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly 
    450                 455                 460                 


Glu Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Thr Leu Asp Val 
465                 470                 475                 480 


Phe Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser 
                485                 490                 495     


Ser Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu 
            500                 505                 510         


Gly Thr Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser 
        515                 520                 525             


Arg Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile 
    530                 535                 540                 


Cys Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu 
545                 550                 555                 560 


Asp Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro 
                565                 570                 575     


Gln Glu Leu Leu 
            580 


<210>  1961
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN2B__Homo_sapiens__NP_004927

<400>  1961

Met Arg Glu Glu Asn Lys Gly Met Pro Ser Gly Gly Gly Ser Asp Glu 
1               5                   10                  15      


Gly Leu Ala Ser Ala Ala Ala Arg Gly Leu Val Glu Lys Val Arg Gln 
            20                  25                  30          


Leu Leu Glu Ala Gly Ala Asp Pro Asn Gly Val Asn Arg Phe Gly Arg 
        35                  40                  45              


Arg Ala Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu 
    50                  55                  60                  


Leu Leu Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu 
65                  70                  75                  80  


Thr Arg Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu 
                85                  90                  95      


Val Val Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp 
            100                 105                 110         


Gly Arg Leu Pro Val Asp Leu Ala Glu Glu Arg Gly His Arg Asp Val 
        115                 120                 125             


Ala Gly Tyr Leu Arg Thr Ala Thr Gly Asp 
    130                 135             


<210>  1962
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN2C__Homo_sapiens__NP_001253

<400>  1962

Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly 
1               5                   10                  15      


Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn 
            20                  25                  30          


Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly 
        35                  40                  45              


Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp 
    50                  55                  60                  


Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala 
65                  70                  75                  80  


Gly Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val 
                85                  90                  95      


Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys 
            100                 105                 110         


Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser 
        115                 120                 125             


Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala 
    130                 135                 140                 


Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Asn Leu Gln 
                165             


<210>  1963
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN2D__Homo_sapiens__NP_001791

<400>  1963

Met Leu Leu Glu Glu Val Arg Ala Gly Asp Arg Leu Ser Gly Ala Ala 
1               5                   10                  15      


Ala Arg Gly Asp Val Gln Glu Val Arg Arg Leu Leu His Arg Glu Leu 
            20                  25                  30          


Val His Pro Asp Ala Leu Asn Arg Phe Gly Lys Thr Ala Leu Gln Val 
        35                  40                  45              


Met Met Phe Gly Ser Thr Ala Ile Ala Leu Glu Leu Leu Lys Gln Gly 
    50                  55                  60                  


Ala Ser Pro Asn Val Gln Asp Thr Ser Gly Thr Ser Pro Val His Asp 
65                  70                  75                  80  


Ala Ala Arg Thr Gly Phe Leu Asp Thr Leu Lys Val Leu Val Glu His 
                85                  90                  95      


Gly Ala Asp Val Asn Val Pro Asp Gly Thr Gly Ala Leu Pro Ile His 
            100                 105                 110         


Leu Ala Val Gln Glu Gly His Thr Ala Val Val Ser Phe Leu Ala Ala 
        115                 120                 125             


Glu Ser Asp Leu His Arg Arg Asp Ala Arg Gly Leu Thr Pro Leu Glu 
    130                 135                 140                 


Leu Ala Leu Gln Arg Gly Ala Gln Asp Leu Val Asp Ile Leu Gln Gly 
145                 150                 155                 160 


His Met Val Ala Pro Leu 
                165     


<210>  1964
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKN3__Homo_sapiens__NP_001124323

<400>  1964

Met Lys Pro Pro Ser Ser Ile Gln Thr Ser Cys Lys Phe Lys Asp Val 
1               5                   10                  15      


Arg Arg Asn Val Gln Lys Asp Thr Glu Glu Leu Lys Ser Cys Gly Ile 
            20                  25                  30          


Gln Asp Ile Phe Val Phe Cys Thr Arg Gly Glu Leu Ser Lys Tyr Arg 
        35                  40                  45              


Val Pro Asn Leu Leu Asp Leu Tyr Gln Gln Cys Gly Ile Ile Thr His 
    50                  55                  60                  


His His Pro Ile Ala Asp Gly Gly Thr Pro Asp Ile Ala Ser Cys Cys 
65                  70                  75                  80  


Glu Ile Met Glu Glu Leu Thr Thr Cys Leu Lys Asn Tyr Arg Lys Thr 
                85                  90                  95      


Leu Ile His Cys Tyr Gly Gly Leu Gly Arg Ser Cys Leu Val Ala Ala 
            100                 105                 110         


Cys Leu Leu Leu Tyr Leu Ser Asp Thr Ile Ser Pro Glu Gln Ala Ile 
        115                 120                 125             


Asp Ser Leu Arg Asp Leu Arg Gly Ser Gly Ala Ile Gln Thr Ile Lys 
    130                 135                 140                 


Gln Tyr Asn Tyr Leu His Glu Phe Arg Asp Lys Leu Ala Ala His Leu 
145                 150                 155                 160 


Ser Ser Arg Asp Ser Gln Ser Arg Ser Val Ser Arg 
                165                 170         


<210>  1965
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDNF__Homo_sapiens__NP_001025125

<400>  1965

Met Trp Cys Ala Ser Pro Val Ala Val Val Ala Phe Cys Ala Gly Leu 
1               5                   10                  15      


Leu Val Ser His Pro Val Leu Thr Gln Gly Gln Glu Ala Gly Gly Arg 
            20                  25                  30          


Pro Gly Ala Asp Cys Glu Val Cys Lys Glu Phe Leu Asn Arg Phe Tyr 
        35                  40                  45              


Lys Ser Leu Ile Asp Arg Gly Val Asn Phe Ser Leu Asp Thr Ile Glu 
    50                  55                  60                  


Lys Glu Leu Ile Ser Phe Cys Leu Asp Thr Lys Gly Lys Glu Asn Arg 
65                  70                  75                  80  


Leu Cys Tyr Tyr Leu Gly Ala Thr Lys Asp Ala Ala Thr Lys Ile Leu 
                85                  90                  95      


Ser Glu Val Thr Arg Pro Met Ser Val His Met Pro Ala Met Lys Ile 
            100                 105                 110         


Cys Glu Lys Leu Lys Lys Leu Asp Ser Gln Ile Cys Glu Leu Lys Tyr 
        115                 120                 125             


Glu Lys Thr Leu Asp Leu Ala Ser Val Asp Leu Arg Lys Met Arg Val 
    130                 135                 140                 


Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys Arg Ala 
145                 150                 155                 160 


Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Gln Glu Leu Ala Pro 
                165                 170                 175     


Lys Tyr Ala Ala Thr His Pro Lys Thr Glu Leu 
            180                 185         


<210>  1966
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDO1__Homo_sapiens__NP_001792

<400>  1966

Met Glu Gln Thr Glu Val Leu Lys Pro Arg Thr Leu Ala Asp Leu Ile 
1               5                   10                  15      


Arg Ile Leu His Gln Leu Phe Ala Gly Asp Glu Val Asn Val Glu Glu 
            20                  25                  30          


Val Gln Ala Ile Met Glu Ala Tyr Glu Ser Asp Pro Thr Glu Trp Ala 
        35                  40                  45              


Met Tyr Ala Lys Phe Asp Gln Tyr Arg Tyr Thr Arg Asn Leu Val Asp 
    50                  55                  60                  


Gln Gly Asn Gly Lys Phe Asn Leu Met Ile Leu Cys Trp Gly Glu Gly 
65                  70                  75                  80  


His Gly Ser Ser Ile His Asp His Thr Asn Ser His Cys Phe Leu Lys 
                85                  90                  95      


Met Leu Gln Gly Asn Leu Lys Glu Thr Leu Phe Ala Trp Pro Asp Lys 
            100                 105                 110         


Lys Ser Asn Glu Met Val Lys Lys Ser Glu Arg Val Leu Arg Glu Asn 
        115                 120                 125             


Gln Cys Ala Tyr Ile Asn Asp Ser Ile Gly Leu His Arg Val Glu Asn 
    130                 135                 140                 


Ile Ser His Thr Glu Pro Ala Val Ser Leu His Leu Tyr Ser Pro Pro 
145                 150                 155                 160 


Phe Asp Thr Cys His Ala Phe Asp Gln Arg Thr Gly His Lys Asn Lys 
                165                 170                 175     


Val Thr Met Thr Phe His Ser Lys Phe Gly Ile Arg Thr Pro Asn Ala 
            180                 185                 190         


Thr Ser Gly Ser Leu Glu Asn Asn 
        195                 200 


<210>  1967
<211>  1287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDON__Homo_sapiens__XP_011541167

<400>  1967

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Thr 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Thr Lys His Val 
        115                 120                 125             


Ile Thr Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Thr Glu Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu 
                165                 170                 175     


Gln Ile Leu Asn Val Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala 
            180                 185                 190         


Ala Tyr Asn Pro Val Thr His Gln Leu Lys Val Glu Pro Ile Gly Arg 
        195                 200                 205             


Lys Leu Leu Val Ser Arg Pro Ser Ser Asp Asp Val His Ile Leu His 
    210                 215                 220                 


Pro Thr His Ser Gln Ala Leu Ala Val Leu Ser Arg Ser Pro Val Thr 
225                 230                 235                 240 


Leu Glu Cys Val Val Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu 
                245                 250                 255     


Lys Asp Gly Gln Asp Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr 
            260                 265                 270         


Ser His Leu Ala Thr Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr 
        275                 280                 285             


Ser Cys Met Ala Gly Asn Lys Ser Gly Asp Val Lys Tyr Val Thr Tyr 
    290                 295                 300                 


Met Val Asn Val Leu Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp 
305                 310                 315                 320 


Gln Ile Val Ser Leu Gly Ala Thr Val His Phe Thr Cys Asp Val His 
                325                 330                 335     


Gly Asn Pro Ala Pro Asn Cys Thr Trp Phe His Asn Ala Gln Pro Ile 
            340                 345                 350         


His Pro Ser Ala Arg His Leu Thr Ala Gly Asn Gly Leu Lys Ile Ser 
        355                 360                 365             


Gly Val Thr Val Glu Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn 
    370                 375                 380                 


Gly Ile Gly Phe Met His Ser Thr Gly Arg Leu Glu Ile Glu Asn Asp 
385                 390                 395                 400 


Gly Gly Phe Lys Pro Val Ile Ile Thr Ala Pro Val Ser Ala Lys Val 
                405                 410                 415     


Ala Asp Gly Asp Phe Val Thr Leu Ser Cys Asn Ala Ser Gly Leu Pro 
            420                 425                 430         


Val Pro Val Ile Arg Trp Tyr Asp Ser His Gly Leu Ile Thr Ser His 
        435                 440                 445             


Pro Ser Gln Val Leu Arg Ser Lys Ser Arg Lys Ser Gln Leu Ser Arg 
    450                 455                 460                 


Pro Glu Gly Leu Asn Leu Glu Pro Val Tyr Phe Val Leu Ser Gln Ala 
465                 470                 475                 480 


Gly Ala Ser Ser Leu His Ile Gln Ala Val Thr Gln Glu His Ala Gly 
                485                 490                 495     


Lys Tyr Ile Cys Glu Ala Ala Asn Glu His Gly Thr Thr Gln Ala Glu 
            500                 505                 510         


Ala Ser Leu Met Val Val Pro Phe Glu Thr Asn Thr Lys Ala Glu Thr 
        515                 520                 525             


Val Thr Leu Pro Asp Ala Ala Gln Asn Asp Asp Arg Ser Lys Arg Asp 
    530                 535                 540                 


Gly Ser Glu Thr Gly Leu Leu Ser Ser Phe Pro Val Lys Val His Pro 
545                 550                 555                 560 


Ser Ala Val Glu Ser Ala Pro Glu Lys Asn Ala Ser Gly Ile Ser Val 
                565                 570                 575     


Pro Asp Ala Pro Ile Ile Leu Ser Pro Pro Gln Thr His Thr Pro Asp 
            580                 585                 590         


Thr Tyr Asn Leu Val Trp Arg Ala Gly Lys Asp Gly Gly Leu Pro Ile 
        595                 600                 605             


Asn Ala Tyr Phe Val Lys Tyr Arg Lys Leu Asp Asp Gly Val Gly Met 
    610                 615                 620                 


Leu Gly Ser Trp His Thr Val Arg Val Pro Gly Ser Glu Asn Glu Leu 
625                 630                 635                 640 


His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met Val 
                645                 650                 655     


Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Thr Phe Arg 
            660                 665                 670         


Thr Ser Lys Glu Lys Thr Ala Ser Ser Lys Asn Thr Gln Ala Ser Ser 
        675                 680                 685             


Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala Asn 
    690                 695                 700                 


Asn Asn Phe Gly Val Val Leu Thr Asp Ser Ser Arg His Ser Gly Val 
705                 710                 715                 720 


Pro Glu Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser 
                725                 730                 735     


Val Tyr Val Thr Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile Thr 
            740                 745                 750         


Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Thr Ser Asn Trp Leu Val 
        755                 760                 765             


Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg Ser 
    770                 775                 780                 


Leu Glu Pro Gly Ser Thr Tyr Lys Phe Arg Val Ile Ala Ile Asn His 
785                 790                 795                 800 


Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val Val 
                805                 810                 815     


Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Thr Gly Pro His Ile 
            820                 825                 830         


Ala Tyr Thr Glu Ala Val Ser Asp Thr Gln Ile Met Leu Lys Trp Thr 
        835                 840                 845             


Tyr Ile Pro Ser Ser Asn Asn Asn Thr Pro Ile Gln Gly Phe Tyr Ile 
    850                 855                 860                 


Tyr Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg Asp 
865                 870                 875                 880 


Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln Pro 
                885                 890                 895     


Glu Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu 
            900                 905                 910         


Ser Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Val Lys Arg Val 
        915                 920                 925             


Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Thr Pro Pro Asn 
    930                 935                 940                 


Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Thr Ser Pro Ala Arg 
945                 950                 955                 960 


Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val Met 
                965                 970                 975     


Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn Arg 
            980                 985                 990         


Gln Gln Asn Thr Ile Gln Lys Tyr  Asp Pro Pro Gly Tyr  Leu Tyr Gln 
        995                 1000                 1005             


Gly Ser  Asp Met Asn Gly Gln  Met Val Asp Tyr Thr  Thr Leu Ser 
    1010                 1015                 1020             


Gly Ala  Ser Gln Ile Asn Gly  Asn Val His Gly Gly  Phe Leu Thr 
    1025                 1030                 1035             


Asn Gly  Gly Leu Ser Ser Gly  Tyr Ser His Leu His  His Lys Val 
    1040                 1045                 1050             


Pro Asn  Ala Val Asn Gly Ile  Val Asn Gly Ser Leu  Asn Gly Gly 
    1055                 1060                 1065             


Leu Tyr  Ser Gly His Ser Asn  Ser Leu Thr Arg Thr  His Val Asp 
    1070                 1075                 1080             


Phe Glu  His Pro His His Leu  Val Asn Gly Gly Gly  Met Tyr Thr 
    1085                 1090                 1095             


Ala Val  Pro Gln Ile Asp Pro  Leu Glu Cys Val Asn  Cys Arg Asn 
    1100                 1105                 1110             


Cys Arg  Asn Asn Asn Arg Cys  Phe Thr Lys Thr Asn  Ser Thr Phe 
    1115                 1120                 1125             


Ser Ser  Ser Pro Pro Pro Val  Val Pro Val Val Ala  Pro Tyr Pro 
    1130                 1135                 1140             


Gln Asp  Gly Leu Glu Met Lys  Pro Leu Ser His Val  Lys Val Pro 
    1145                 1150                 1155             


Val Cys  Leu Thr Ser Ala Val  Pro Asp Cys Gly Gln  Leu Pro Glu 
    1160                 1165                 1170             


Glu Ser  Val Lys Asp Asn Val  Glu Pro Val Pro Thr  Gln Arg Thr 
    1175                 1180                 1185             


Cys Cys  Gln Asp Ile Val Asn  Asp Val Ser Ser Asp  Gly Ser Glu 
    1190                 1195                 1200             


Asp Pro  Ala Glu Phe Ser Arg  Gly Gln Glu Gly Met  Ile Asn Leu 
    1205                 1210                 1215             


Arg Ile  Pro Asp His Leu Gln  Leu Ala Lys Ser Cys  Val Trp Glu 
    1220                 1225                 1230             


Gly Asp  Ser Cys Ala His Ser  Glu Thr Glu Ile Asn  Ile Val Ser 
    1235                 1240                 1245             


Trp Asn  Ala Leu Ile Leu Pro  Pro Val Pro Glu Gly  Cys Ala Glu 
    1250                 1255                 1260             


Lys Thr  Met Trp Ser Pro Pro  Gly Ile Pro Leu Asp  Ser Pro Thr 
    1265                 1270                 1275             


Glu Val  Leu Gln Gln Pro Arg  Glu Thr 
    1280                 1285         


<210>  1968
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1__Homo_sapiens__NP_004056

<400>  1968

Met Ala Trp Leu Glu Asp Val Asp Phe Leu Glu Asp Val Pro Leu Leu 
1               5                   10                  15      


Glu Asp Ile Pro Leu Leu Glu Asp Val Pro Leu Leu Glu Asp Val Pro 
            20                  25                  30          


Leu Leu Glu Asp Thr Ser Arg Leu Glu Asp Ile Asn Leu Met Glu Asp 
        35                  40                  45              


Met Ala Leu Leu Glu Asp Val Asp Leu Leu Glu Asp Thr Asp Phe Leu 
    50                  55                  60                  


Glu Asp Leu Asp Phe Ser Glu Ala Met Asp Leu Arg Glu Asp Lys Asp 
65                  70                  75                  80  


Phe Leu Glu Asp Met Asp Ser Leu Glu Asp Met Ala Leu Leu Glu Asp 
                85                  90                  95      


Val Asp Leu Leu Glu Asp Thr Asp Phe Leu Glu Asp Pro Asp Phe Leu 
            100                 105                 110         


Glu Ala Ile Asp Leu Arg Glu Asp Lys Asp Phe Leu Glu Asp Met Asp 
        115                 120                 125             


Ser Leu Glu Asp Leu Glu Ala Ile Gly Arg Cys Gly Phe Ser Gly Arg 
    130                 135                 140                 


His Gly Phe Phe Gly Arg Arg Arg Phe Ser Gly Arg Pro Lys Leu Ser 
145                 150                 155                 160 


Gly Arg Leu Gly Leu Leu Gly Arg Arg Gly Phe Ser Gly Arg Leu Gly 
                165                 170                 175     


Gly Tyr Trp Lys Thr Trp Ile Phe Trp Lys Thr Trp Ile Phe Trp Lys 
            180                 185                 190         


Thr Trp Ile Phe Arg Lys Thr Tyr Ile Gly Trp Lys Thr Trp Ile Phe 
        195                 200                 205             


Ser Gly Arg Cys Gly Leu Thr Gly Arg Pro Gly Phe Gly Gly Arg Arg 
    210                 215                 220                 


Arg Phe Phe Trp Lys Thr Leu Thr Asp Trp Lys Thr Trp Ile Ser Phe 
225                 230                 235                 240 


Trp Lys Thr Leu Ile Asp Trp Lys Thr Trp Ile Ser Phe Trp Lys Thr 
                245                 250                 255     


Leu Ile Asp Trp Lys Ile 
            260         


<210>  1969
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2__Homo_sapiens__NP_001793

<400>  1969

Met Leu Ala Glu Asn Leu Val Glu Glu Phe Glu Met Lys Glu Asp Glu 
1               5                   10                  15      


Pro Trp Tyr Asp His Gln Asp Leu Gln Gln Asp Leu Gln Leu Ala Ala 
            20                  25                  30          


Glu Leu Gly Lys Thr Leu Leu Asp Arg Asn Thr Glu Leu Glu Asp Ser 
        35                  40                  45              


Val Gln Gln Met Tyr Thr Thr Asn Gln Glu Gln Leu Gln Glu Ile Glu 
    50                  55                  60                  


Tyr Leu Thr Lys Gln Val Glu Leu Leu Arg Gln Met Asn Glu Gln His 
65                  70                  75                  80  


Ala Lys Val Tyr Glu Gln Leu Asp Val Thr Ala Arg Glu Leu Glu Glu 
                85                  90                  95      


Thr Asn Gln Lys Leu Val Ala Asp Ser Lys Ala Ser Gln Gln Lys Ile 
            100                 105                 110         


Leu Ser Leu Thr Glu Thr Ile Glu Cys Leu Gln Thr Asn Ile Asp His 
        115                 120                 125             


Leu Gln Ser Gln Val Glu Glu Leu Lys Ser Ser Gly Gln Gly Arg Arg 
    130                 135                 140                 


Ser Pro Gly Lys Cys Asp Gln Glu Lys Pro Ala Pro Ser Phe Ala Cys 
145                 150                 155                 160 


Leu Lys Glu Leu Tyr Asp Leu Arg Gln His Phe Val Tyr Asp His Val 
                165                 170                 175     


Phe Ala Glu Lys Ile Thr Ser Leu Gln Gly Gln Pro Ser Pro Asp Glu 
            180                 185                 190         


Glu Glu Asn Glu His Leu Lys Lys Thr Val Thr Met Leu Gln Ala Gln 
        195                 200                 205             


Leu Ser Leu Glu Arg Gln Lys Arg Val Thr Met Glu Glu Glu Tyr Gly 
    210                 215                 220                 


Leu Val Leu Lys Glu Asn Ser Glu Leu Glu Gln Gln Leu Gly Ala Thr 
225                 230                 235                 240 


Gly Ala Tyr Arg Ala Arg Ala Leu Glu Leu Glu Ala Glu Val Ala Glu 
                245                 250                 255     


Met Arg Gln Met Leu Gln Ser Glu His Pro Phe Val Asn Gly Val Glu 
            260                 265                 270         


Lys Leu Val Pro Asp Ser Leu Tyr Val Pro Phe Lys Glu Pro Ser Gln 
        275                 280                 285             


Ser Leu Leu Glu Glu Met Phe Leu Thr Val Pro Glu Ser His Arg Lys 
    290                 295                 300                 


Pro Leu Lys Arg Ser Ser Ser Glu Thr Ile Leu Ser Ser Leu Ala Gly 
305                 310                 315                 320 


Ser Asp Ile Val Lys Gly His Glu Glu Thr Cys Ile Arg Arg Ala Lys 
                325                 330                 335     


Ala Val Lys Gln Arg Gly Ile Ser Leu Leu His Glu Val Asp Thr Gln 
            340                 345                 350         


Tyr Ser Ala Leu Lys Val Lys Tyr Glu Glu Leu Leu Lys Lys Cys Gln 
        355                 360                 365             


Glu Glu Gln Asp Ser Leu Ser His Lys Ala Val Gln Thr Ser Arg Ala 
    370                 375                 380                 


Ala Ala Lys Asp Leu Thr Gly Val Asn Ala Gln Ser Glu Pro Val Ala 
385                 390                 395                 400 


Ser Gly Trp Glu Leu Ala Ser Val Asn Pro Glu Pro Val Ser Ser Pro 
                405                 410                 415     


Thr Thr Pro Pro Glu Tyr Lys Ala Leu Phe Lys Glu Ile Phe Ser Cys 
            420                 425                 430         


Ile Lys Lys Thr Lys Gln Glu Ile Asp Glu Gln Arg Thr Lys Tyr Arg 
        435                 440                 445             


Ser Leu Ser Ser His Ser 
    450                 


<210>  1970
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDS2__Homo_sapiens__NP_003809

<400>  1970

Met Thr Glu Leu Arg Gln Arg Val Ala His Glu Pro Val Ala Pro Pro 
1               5                   10                  15      


Glu Asp Lys Glu Ser Glu Ser Glu Ala Lys Val Asp Gly Glu Thr Ala 
            20                  25                  30          


Ser Asp Ser Glu Ser Arg Ala Glu Ser Ala Pro Leu Pro Val Ser Ala 
        35                  40                  45              


Asp Asp Thr Pro Glu Val Leu Asn Arg Ala Leu Ser Asn Leu Ser Ser 
    50                  55                  60                  


Arg Trp Lys Asn Trp Trp Val Arg Gly Ile Leu Thr Leu Ala Met Ile 
65                  70                  75                  80  


Ala Phe Phe Phe Ile Ile Ile Tyr Leu Gly Pro Met Val Leu Met Ile 
                85                  90                  95      


Ile Val Met Cys Val Gln Ile Lys Cys Phe His Glu Ile Ile Thr Ile 
            100                 105                 110         


Gly Tyr Asn Val Tyr His Ser Tyr Asp Leu Pro Trp Phe Arg Thr Leu 
        115                 120                 125             


Ser Trp Tyr Phe Leu Leu Cys Val Asn Tyr Phe Phe Tyr Gly Glu Thr 
    130                 135                 140                 


Val Thr Asp Tyr Phe Phe Thr Leu Val Gln Arg Glu Glu Pro Leu Arg 
145                 150                 155                 160 


Ile Leu Ser Lys Tyr His Arg Phe Ile Ser Phe Thr Leu Tyr Leu Ile 
                165                 170                 175     


Gly Phe Cys Met Phe Val Leu Ser Leu Val Lys Lys His Tyr Arg Leu 
            180                 185                 190         


Gln Phe Tyr Met Phe Gly Trp Thr His Val Thr Leu Leu Ile Val Val 
        195                 200                 205             


Thr Gln Ser His Leu Val Ile His Asn Leu Phe Glu Gly Met Ile Trp 
    210                 215                 220                 


Phe Ile Val Pro Ile Ser Cys Val Ile Cys Asn Asp Ile Met Ala Tyr 
225                 230                 235                 240 


Met Phe Gly Phe Phe Phe Gly Arg Thr Pro Leu Ile Lys Leu Ser Pro 
                245                 250                 255     


Lys Lys Thr Trp Glu Gly Phe Ile Gly Gly Phe Phe Ala Thr Val Val 
            260                 265                 270         


Phe Gly Leu Leu Leu Ser Tyr Val Met Ser Gly Tyr Arg Cys Phe Val 
        275                 280                 285             


Cys Pro Val Glu Tyr Asn Asn Asp Thr Asn Ser Phe Thr Val Asp Cys 
    290                 295                 300                 


Glu Pro Ser Asp Leu Phe Arg Leu Gln Glu Tyr Asn Ile Pro Gly Val 
305                 310                 315                 320 


Ile Gln Ser Val Ile Gly Trp Lys Thr Val Arg Met Tyr Pro Phe Gln 
                325                 330                 335     


Ile His Ser Ile Ala Leu Ser Thr Phe Ala Ser Leu Ile Gly Pro Phe 
            340                 345                 350         


Gly Gly Phe Phe Ala Ser Gly Phe Lys Arg Ala Phe Lys Ile Lys Asp 
        355                 360                 365             


Phe Ala Asn Thr Ile Pro Gly His Gly Gly Ile Met Asp Arg Phe Asp 
    370                 375                 380                 


Cys Gln Tyr Leu Met Ala Thr Phe Val Asn Val Tyr Ile Ala Ser Phe 
385                 390                 395                 400 


Ile Arg Gly Pro Asn Pro Ser Lys Leu Ile Gln Gln Phe Leu Thr Leu 
                405                 410                 415     


Arg Pro Asp Gln Gln Leu His Ile Phe Asn Thr Leu Arg Ser His Leu 
            420                 425                 430         


Ile Asp Lys Gly Met Leu Thr Ser Thr Thr Glu Asp Glu 
        435                 440                 445 


<210>  1971
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDT1__Homo_sapiens__NP_112190

<400>  1971

Met Glu Gln Arg Arg Val Thr Asp Phe Phe Ala Arg Arg Arg Pro Gly 
1               5                   10                  15      


Pro Pro Arg Ile Ala Pro Pro Lys Leu Ala Cys Arg Thr Pro Ser Pro 
            20                  25                  30          


Ala Arg Pro Ala Leu Arg Ala Pro Ala Ser Ala Thr Ser Gly Ser Arg 
        35                  40                  45              


Lys Arg Ala Arg Pro Pro Ala Ala Pro Gly Arg Asp Gln Ala Arg Pro 
    50                  55                  60                  


Pro Ala Arg Arg Arg Leu Arg Leu Ser Val Asp Glu Val Ser Ser Pro 
65                  70                  75                  80  


Ser Thr Pro Glu Ala Pro Asp Ile Pro Ala Cys Pro Ser Pro Gly Gln 
                85                  90                  95      


Lys Ile Lys Lys Ser Thr Pro Ala Ala Gly Gln Pro Pro His Leu Thr 
            100                 105                 110         


Ser Ala Gln Asp Gln Asp Thr Ile Ser Glu Leu Ala Ser Cys Leu Gln 
        115                 120                 125             


Arg Ala Arg Glu Leu Gly Ala Arg Val Arg Ala Leu Lys Ala Ser Ala 
    130                 135                 140                 


Gln Asp Ala Gly Glu Ser Cys Thr Pro Glu Ala Glu Gly Arg Pro Glu 
145                 150                 155                 160 


Glu Pro Cys Gly Glu Lys Ala Pro Ala Tyr Gln Arg Phe His Ala Leu 
                165                 170                 175     


Ala Gln Pro Gly Leu Pro Gly Leu Val Leu Pro Tyr Lys Tyr Gln Val 
            180                 185                 190         


Leu Ala Glu Met Phe Arg Ser Met Asp Thr Ile Val Gly Met Leu His 
        195                 200                 205             


Asn Arg Ser Glu Thr Pro Thr Phe Ala Lys Val Gln Arg Gly Val Gln 
    210                 215                 220                 


Asp Met Met Arg Arg Arg Phe Glu Glu Cys Asn Val Gly Gln Ile Lys 
225                 230                 235                 240 


Thr Val Tyr Pro Ala Ser Tyr Arg Phe Arg Gln Glu Arg Ser Val Pro 
                245                 250                 255     


Thr Phe Lys Asp Gly Thr Arg Arg Ser Asp Tyr Gln Leu Thr Ile Glu 
            260                 265                 270         


Pro Leu Leu Glu Gln Glu Ala Asp Gly Ala Ala Pro Gln Leu Thr Ala 
        275                 280                 285             


Ser Arg Leu Leu Gln Arg Arg Gln Ile Phe Ser Gln Lys Leu Val Glu 
    290                 295                 300                 


His Val Lys Glu His His Lys Ala Phe Leu Ala Ser Leu Ser Pro Ala 
305                 310                 315                 320 


Met Val Val Pro Glu Asp Gln Leu Thr Arg Trp His Pro Arg Phe Asn 
                325                 330                 335     


Val Asp Glu Val Pro Asp Ile Glu Pro Ala Ala Leu Pro Gln Pro Pro 
            340                 345                 350         


Ala Thr Glu Lys Leu Thr Thr Ala Gln Glu Val Leu Ala Arg Ala Arg 
        355                 360                 365             


Asn Leu Ile Ser Pro Arg Met Glu Lys Ala Leu Ser Gln Leu Ala Leu 
    370                 375                 380                 


Arg Ser Ala Ala Pro Ser Ser Pro Gly Ser Pro Arg Pro Ala Leu Pro 
385                 390                 395                 400 


Ala Thr Pro Pro Ala Thr Pro Pro Ala Ala Ser Pro Ser Ala Leu Lys 
                405                 410                 415     


Gly Val Ser Gln Asp Leu Leu Glu Arg Ile Arg Ala Lys Glu Ala Gln 
            420                 425                 430         


Lys Gln Leu Ala Gln Met Thr Arg Cys Pro Glu Gln Glu Gln Arg Leu 
        435                 440                 445             


Gln Arg Leu Glu Arg Leu Pro Glu Leu Ala Arg Val Leu Arg Ser Val 
    450                 455                 460                 


Phe Val Ser Glu Arg Lys Pro Ala Leu Ser Met Glu Val Ala Cys Ala 
465                 470                 475                 480 


Arg Met Val Gly Ser Cys Cys Thr Ile Met Ser Pro Gly Glu Met Glu 
                485                 490                 495     


Lys His Leu Leu Leu Leu Ser Glu Leu Leu Pro Asp Trp Leu Ser Leu 
            500                 505                 510         


His Arg Ile Arg Thr Asp Thr Tyr Val Lys Leu Asp Lys Ala Ala Asp 
        515                 520                 525             


Leu Ala His Ile Thr Ala Arg Leu Ala His Gln Thr Arg Ala Glu Glu 
    530                 535                 540                 


Gly Leu 
545     


<210>  1972
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDV3__Homo_sapiens__NP_001127894

<400>  1972

Met Ala Glu Thr Glu Glu Arg Ser Leu Asp Asn Phe Phe Ala Lys Arg 
1               5                   10                  15      


Asp Lys Lys Lys Lys Lys Glu Arg Ser Asn Arg Ala Ala Ser Ala Ala 
            20                  25                  30          


Gly Ala Ala Gly Ser Ala Gly Gly Ser Ser Gly Ala Ala Gly Ala Ala 
        35                  40                  45              


Gly Gly Gly Ala Gly Ala Gly Thr Arg Pro Gly Asp Gly Gly Thr Ala 
    50                  55                  60                  


Ser Ala Gly Ala Ala Gly Pro Gly Ala Ala Thr Lys Ala Val Thr Lys 
65                  70                  75                  80  


Asp Glu Asp Glu Trp Lys Glu Leu Glu Gln Lys Glu Val Asp Tyr Ser 
                85                  90                  95      


Gly Leu Arg Val Gln Ala Met Gln Ile Ser Ser Glu Lys Glu Glu Asp 
            100                 105                 110         


Asp Asn Glu Lys Arg Gln Asp Pro Gly Asp Asn Trp Glu Glu Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Met Glu Lys Ser Ser Gly Pro Trp Asn Lys Thr 
    130                 135                 140                 


Ala Pro Val Gln Ala Pro Pro Ala Pro Val Ile Val Thr Glu Thr Pro 
145                 150                 155                 160 


Glu Pro Ala Met Thr Ser Gly Val Tyr Arg Pro Pro Gly Ala Arg Leu 
                165                 170                 175     


Thr Thr Thr Arg Lys Thr Pro Gln Gly Pro Pro Glu Ile Tyr Ser Asp 
            180                 185                 190         


Thr Gln Phe Pro Ser Leu Gln Ser Thr Ala Lys His Val Glu Ser Arg 
        195                 200                 205             


Asn Arg Tyr Leu Lys 
    210             


<210>  1973
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDX1__Homo_sapiens__NP_001795

<400>  1973

Met Tyr Val Gly Tyr Val Leu Asp Lys Asp Ser Pro Val Tyr Pro Gly 
1               5                   10                  15      


Pro Ala Arg Pro Ala Ser Leu Gly Leu Gly Pro Gln Ala Tyr Gly Pro 
            20                  25                  30          


Pro Ala Pro Pro Pro Ala Pro Pro Gln Tyr Pro Asp Phe Ser Ser Tyr 
        35                  40                  45              


Ser His Val Glu Pro Ala Pro Ala Pro Pro Thr Ala Trp Gly Ala Pro 
    50                  55                  60                  


Phe Pro Ala Pro Lys Asp Asp Trp Ala Ala Ala Tyr Gly Pro Gly Pro 
65                  70                  75                  80  


Ala Ala Pro Ala Ala Ser Pro Ala Ser Leu Ala Phe Gly Pro Pro Pro 
                85                  90                  95      


Asp Phe Ser Pro Val Pro Ala Pro Pro Gly Pro Gly Pro Gly Leu Leu 
            100                 105                 110         


Ala Gln Pro Leu Gly Gly Pro Gly Thr Pro Ser Ser Pro Gly Ala Gln 
        115                 120                 125             


Arg Pro Thr Pro Tyr Glu Trp Met Arg Arg Ser Val Ala Ala Gly Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Lys Thr Arg Thr Lys Asp Lys Tyr Arg Val Val 
145                 150                 155                 160 


Tyr Thr Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
                165                 170                 175     


Arg Tyr Ile Thr Ile Arg Arg Lys Ser Glu Leu Ala Ala Asn Leu Gly 
            180                 185                 190         


Leu Thr Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
        195                 200                 205             


Glu Arg Lys Val Asn Lys Lys Lys Gln Gln Gln Gln Gln Pro Pro Gln 
    210                 215                 220                 


Pro Pro Met Ala His Asp Ile Thr Ala Thr Pro Ala Gly Pro Ser Leu 
225                 230                 235                 240 


Gly Gly Leu Cys Pro Ser Asn Thr Ser Leu Leu Ala Thr Ser Ser Pro 
                245                 250                 255     


Met Pro Val Lys Glu Glu Phe Leu Pro 
            260                 265 


<210>  1974
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDX2__Homo_sapiens__NP_001256

<400>  1974

Met Tyr Val Ser Tyr Leu Leu Asp Lys Asp Val Ser Met Tyr Pro Ser 
1               5                   10                  15      


Ser Val Arg His Ser Gly Gly Leu Asn Leu Ala Pro Gln Asn Phe Val 
            20                  25                  30          


Ser Pro Pro Gln Tyr Pro Asp Tyr Gly Gly Tyr His Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Asn Leu Asp Ser Ala Gln Ser Pro Gly Pro Ser 
    50                  55                  60                  


Trp Pro Ala Ala Tyr Gly Ala Pro Leu Arg Glu Asp Trp Asn Gly Tyr 
65                  70                  75                  80  


Ala Pro Gly Gly Ala Ala Ala Ala Ala Asn Ala Val Ala His Gly Leu 
                85                  90                  95      


Asn Gly Gly Ser Pro Ala Ala Ala Met Gly Tyr Ser Ser Pro Ala Asp 
            100                 105                 110         


Tyr His Pro His His His Pro His His His Pro His His Pro Ala Ala 
        115                 120                 125             


Ala Pro Ser Cys Ala Ser Gly Leu Leu Gln Thr Leu Asn Pro Gly Pro 
    130                 135                 140                 


Pro Gly Pro Ala Ala Thr Ala Ala Ala Glu Gln Leu Ser Pro Gly Gly 
145                 150                 155                 160 


Gln Arg Arg Asn Leu Cys Glu Trp Met Arg Lys Pro Ala Gln Gln Ser 
                165                 170                 175     


Leu Gly Ser Gln Val Lys Thr Arg Thr Lys Asp Lys Tyr Arg Val Val 
            180                 185                 190         


Tyr Thr Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
        195                 200                 205             


Arg Tyr Ile Thr Ile Arg Arg Lys Ala Glu Leu Ala Ala Thr Leu Gly 
    210                 215                 220                 


Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
225                 230                 235                 240 


Glu Arg Lys Ile Asn Lys Lys Lys Leu Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Pro Pro Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Pro Gln Pro 
            260                 265                 270         


Gly Pro Leu Arg Ser Val Pro Glu Pro Leu Ser Pro Val Ser Ser Leu 
        275                 280                 285             


Gln Ala Ser Val Ser Gly Ser Val Pro Gly Val Leu Gly Pro Thr Gly 
    290                 295                 300                 


Gly Val Leu Asn Pro Thr Val Thr Gln 
305                 310             


<210>  1975
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDX4__Homo_sapiens__NP_005184

<400>  1975

Met Tyr Gly Ser Cys Leu Leu Glu Lys Glu Ala Gly Met Tyr Pro Gly 
1               5                   10                  15      


Thr Leu Met Ser Pro Gly Gly Asp Gly Thr Ala Gly Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Gly Gly Ser Pro Met Pro Ala Ser Asn Phe Ala Ala Ala Pro 
        35                  40                  45              


Ala Phe Ser His Tyr Met Gly Tyr Pro His Met Pro Ser Met Asp Pro 
    50                  55                  60                  


His Trp Pro Ser Leu Gly Val Trp Gly Ser Pro Tyr Ser Pro Pro Arg 
65                  70                  75                  80  


Glu Asp Trp Ser Val Tyr Pro Gly Pro Ser Ser Thr Met Gly Thr Val 
                85                  90                  95      


Pro Val Asn Asp Val Thr Ser Ser Pro Ala Ala Phe Cys Ser Thr Asp 
            100                 105                 110         


Tyr Ser Asn Leu Gly Pro Val Gly Gly Gly Thr Ser Gly Ser Ser Leu 
        115                 120                 125             


Pro Gly Gln Ala Gly Gly Ser Leu Val Pro Thr Asp Ala Gly Ala Ala 
    130                 135                 140                 


Lys Ala Ser Ser Pro Ser Arg Ser Arg His Ser Pro Tyr Ala Trp Met 
145                 150                 155                 160 


Arg Lys Thr Val Gln Val Thr Gly Lys Thr Arg Thr Lys Glu Lys Tyr 
                165                 170                 175     


Arg Val Val Tyr Thr Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe 
            180                 185                 190         


His Cys Asn Arg Tyr Ile Thr Ile Gln Arg Lys Ser Glu Leu Ala Val 
        195                 200                 205             


Asn Leu Gly Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg 
    210                 215                 220                 


Arg Ala Lys Glu Arg Lys Met Ile Lys Lys Lys Ile Ser Gln Phe Glu 
225                 230                 235                 240 


Asn Ser Gly Gly Ser Val Gln Ser Asp Ser Asp Ser Ile Ser Pro Gly 
                245                 250                 255     


Glu Leu Pro Asn Thr Phe Phe Thr Thr Pro Ser Ala Val Arg Gly Phe 
            260                 265                 270         


Gln Pro Ile Glu Ile Gln Gln Val Ile Val Ser Glu 
        275                 280                 


<210>  1976
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDY1B__Homo_sapiens__NP_001003894

<400>  1976

Met Ala Ser Gln Glu Phe Glu Val Glu Ala Ile Val Asp Lys Arg Gln 
1               5                   10                  15      


Asp Lys Asn Gly Asn Thr Gln Tyr Leu Val Arg Trp Lys Gly Tyr Asp 
            20                  25                  30          


Lys Gln Asp Asp Thr Trp Glu Pro Glu Gln His Leu Met Asn Cys Glu 
        35                  40                  45              


Lys Cys Val His Asp Phe Asn Arg Arg Gln Thr Glu Lys Gln Lys Lys 
    50                  55                  60                  


Leu Thr Trp Thr Thr Thr Ser Arg Ile Phe Ser Asn Asn Ala Arg Arg 
65                  70                  75                  80  


Arg Thr Ser Arg Ser Thr Lys Ala Asn Tyr Ser Lys Asn Ser Pro Lys 
                85                  90                  95      


Thr Pro Val Thr Asp Lys His His Arg Ser Lys Asn Arg Lys Leu Phe 
            100                 105                 110         


Ala Ala Ser Lys Asn Val Arg Arg Lys Ala Ala Ser Ile Leu Ser Asp 
        115                 120                 125             


Thr Lys Asn Met Glu Ile Ile Asn Ser Thr Ile Glu Thr Leu Ala Pro 
    130                 135                 140                 


Asp Ser Pro Phe Asp His Lys Thr Val Ser Gly Phe Gln Lys Leu Glu 
145                 150                 155                 160 


Lys Leu Asp Pro Ile Ala Ala Asp Gln Gln Asp Thr Val Val Phe Lys 
                165                 170                 175     


Val Thr Glu Gly Lys Leu Leu Arg Asp Pro Leu Ser Arg Pro Gly Ala 
            180                 185                 190         


Glu Gln Thr Gly Ile Gln Asn Lys Thr Gln Ile His Pro Leu Met Ser 
        195                 200                 205             


Gln Met Ser Gly Ser Val Thr Ala Ser Met Ala Thr Gly Ser Ala Thr 
    210                 215                 220                 


Arg Lys Gly Ile Val Val Leu Ile Asp Pro Leu Ala Ala Asn Gly Thr 
225                 230                 235                 240 


Thr Asp Met His Thr Ser Val Pro Arg Val Lys Gly Gly Gln Arg Asn 
                245                 250                 255     


Ile Thr Asp Asp Ser Arg Asp Gln Pro Phe Ile Lys Lys Met His Phe 
            260                 265                 270         


Thr Ile Arg Leu Thr Glu Ser Ala Ser Thr Tyr Arg Asp Ile Val Val 
        275                 280                 285             


Lys Lys Glu Asp Gly Phe Thr Gln Ile Val Leu Ser Thr Arg Ser Thr 
    290                 295                 300                 


Glu Lys Asn Ala Leu Asn Thr Glu Val Ile Lys Glu Ile Val Asn Ala 
305                 310                 315                 320 


Leu Asn Ser Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Phe Ser Ala 
                325                 330                 335     


Ala Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Gly Tyr Phe Val Lys 
            340                 345                 350         


His Leu Arg Asn Asn Arg Asn Thr Ala Ser Leu Glu Met Val Asp Thr 
        355                 360                 365             


Ile Lys Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile Val 
    370                 375                 380                 


Val Ser Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu Pro 
385                 390                 395                 400 


Leu Cys Asp Leu Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr Pro 
                405                 410                 415     


Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Ser Ile Thr Phe 
            420                 425                 430         


Pro Lys Met Met Gly Lys Ala Ser Ala Asn Glu Met Leu Ile Ala Gly 
        435                 440                 445             


Arg Lys Leu Thr Ala Arg Glu Ala Cys Ala Lys Gly Leu Val Ser Gln 
    450                 455                 460                 


Val Phe Leu Thr Gly Thr Phe Thr Gln Glu Val Met Ile Gln Ile Lys 
465                 470                 475                 480 


Glu Leu Ala Ser Tyr Asn Pro Ile Val Leu Glu Glu Cys Lys Ala Leu 
                485                 490                 495     


Val Arg Cys Asn Ile Lys Leu Glu Leu Glu Gln Ala Asn Glu Arg Glu 
            500                 505                 510         


Cys Glu Val Leu Arg Lys Ile Trp Ser Ser Ala Gln Gly Ile Glu Ser 
        515                 520                 525             


Met Leu Lys Tyr Val Glu Asn Lys Ile Asp Glu Phe 
    530                 535                 540 


<210>  1977
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDY2B__Homo_sapiens__NP_001001722

<400>  1977

Met Ala Ser Gln Glu Phe Glu Val Glu Ala Ile Val Asp Lys Arg Gln 
1               5                   10                  15      


Asp Lys Asn Gly Asn Thr Gln Tyr Leu Val Arg Trp Lys Gly Tyr Asp 
            20                  25                  30          


Lys Gln Asp Asp Thr Trp Glu Pro Glu Gln His Leu Met Asn Cys Glu 
        35                  40                  45              


Lys Cys Val His Asp Phe Asn Arg Arg Gln Thr Glu Lys Gln Lys Lys 
    50                  55                  60                  


Leu Thr Trp Thr Thr Thr Ser Arg Ile Phe Ser Asn Asn Ala Arg Arg 
65                  70                  75                  80  


Arg Thr Ser Arg Ser Thr Lys Ala Asn Tyr Ser Lys Asn Ser Pro Lys 
                85                  90                  95      


Thr Pro Val Thr Asp Lys His His Arg Ser Lys Asn Cys Lys Leu Phe 
            100                 105                 110         


Ala Ala Ser Lys Asn Val Arg Arg Lys Ala Ala Ser Thr Leu Ser Asp 
        115                 120                 125             


Thr Lys Asn Met Glu Ile Ile Asn Ser Thr Ile Glu Thr Leu Ala Pro 
    130                 135                 140                 


Asp Ser Pro Phe Asp His Lys Lys Thr Val Ser Gly Phe Gln Lys Leu 
145                 150                 155                 160 


Glu Lys Leu Asp Pro Ile Ala Ala Asp Gln Gln Asp Thr Val Val Phe 
                165                 170                 175     


Lys Val Thr Glu Gly Lys Leu Leu Arg Asp Pro Leu Ser His Pro Gly 
            180                 185                 190         


Ala Glu Gln Thr Gly Ile Gln Asn Lys Thr Gln Met His Pro Leu Met 
        195                 200                 205             


Ser Gln Met Ser Gly Ser Val Thr Ala Ser Met Ala Thr Gly Ser Ala 
    210                 215                 220                 


Thr Arg Lys Gly Ile Val Val Leu Ile Asp Pro Leu Ala Ala Asn Gly 
225                 230                 235                 240 


Thr Thr Asp Met His Thr Ser Val Pro Arg Val Lys Gly Gly Gln Arg 
                245                 250                 255     


Asn Ile Thr Asp Asp Ser Arg Gly Gln Pro Phe Ile Lys Lys Met His 
            260                 265                 270         


Phe Thr Ile Arg Leu Thr Glu Ser Ala Ile Thr Tyr Arg Asp Ile Val 
        275                 280                 285             


Val Lys Lys Glu Asp Gly Phe Thr Gln Ile Val Leu Ser Thr Arg Ser 
    290                 295                 300                 


Thr Glu Lys Asn Ala Leu Asn Thr Glu Val Ile Lys Glu Met Val Asn 
305                 310                 315                 320 


Ala Leu Asn Ser Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Phe Ser 
                325                 330                 335     


Ala Ala Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Gly Tyr Phe Val 
            340                 345                 350         


Arg His Leu Arg Asn Asp Arg Asn Thr Ala Ser Leu Glu Met Val Asp 
        355                 360                 365             


Thr Ile Lys Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile 
    370                 375                 380                 


Val Val Ser Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu 
385                 390                 395                 400 


Pro Leu Cys Asp Leu Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr 
                405                 410                 415     


Pro Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Ser Ile Thr 
            420                 425                 430         


Phe Pro Lys Met Met Gly Lys Ala Ser Ala Asn Glu Met Leu Ile Ala 
        435                 440                 445             


Gly Arg Lys Leu Thr Ala Arg Glu Ala Cys Ala Lys Gly Leu Val Ser 
    450                 455                 460                 


Gln Val Phe Leu Thr Gly Thr Phe Thr Gln Glu Val Met Ile Gln Ile 
465                 470                 475                 480 


Lys Glu Leu Ala Ser Tyr Asn Ala Ile Val Leu Glu Glu Cys Lys Ala 
                485                 490                 495     


Leu Val Arg Cys Asn Ile Lys Leu Glu Leu Glu Gln Ala Asn Glu Arg 
            500                 505                 510         


Glu Cys Glu Val Leu Arg Lys Ile Trp Ser Ser Ala Gln Gly Ile Glu 
        515                 520                 525             


Ser Met Leu Lys Tyr Val Glu Asn Lys Ile Asp Glu Phe 
    530                 535                 540     


<210>  1978
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDYL2__Homo_sapiens__NP_689555

<400>  1978

Met Ala Ser Gly Asp Leu Tyr Glu Val Glu Arg Ile Val Asp Lys Arg 
1               5                   10                  15      


Lys Asn Lys Lys Gly Lys Trp Glu Tyr Leu Ile Arg Trp Lys Gly Tyr 
            20                  25                  30          


Gly Ser Thr Glu Asp Thr Trp Glu Pro Glu His His Leu Leu His Cys 
        35                  40                  45              


Glu Glu Phe Ile Asp Glu Phe Asn Gly Leu His Met Ser Lys Asp Lys 
    50                  55                  60                  


Arg Ile Lys Ser Gly Lys Gln Ser Ser Thr Ser Lys Leu Leu Arg Asp 
65                  70                  75                  80  


Ser Arg Gly Pro Ser Val Glu Lys Leu Ser His Arg Pro Ser Asp Pro 
                85                  90                  95      


Gly Lys Ser Lys Gly Thr Ser His Lys Arg Lys Arg Ile Asn Pro Pro 
            100                 105                 110         


Leu Ala Lys Pro Lys Lys Gly Tyr Ser Gly Lys Pro Ser Ser Gly Gly 
        115                 120                 125             


Asp Arg Ala Thr Lys Thr Val Ser Tyr Arg Thr Thr Pro Ser Gly Leu 
    130                 135                 140                 


Gln Ile Met Pro Leu Lys Lys Ser Gln Asn Gly Met Glu Asn Gly Asp 
145                 150                 155                 160 


Ala Gly Ser Glu Lys Asp Glu Arg His Phe Gly Asn Gly Ser His Gln 
                165                 170                 175     


Pro Gly Leu Asp Leu Asn Asp His Val Gly Glu Gln Asp Met Gly Glu 
            180                 185                 190         


Cys Asp Val Asn His Ala Thr Leu Ala Glu Asn Gly Leu Gly Ser Ala 
        195                 200                 205             


Leu Thr Asn Gly Gly Leu Asn Leu His Ser Pro Val Lys Arg Lys Leu 
    210                 215                 220                 


Glu Ala Glu Lys Asp Tyr Val Phe Asp Lys Arg Leu Arg Tyr Ser Val 
225                 230                 235                 240 


Arg Gln Asn Glu Ser Asn Cys Arg Phe Arg Asp Ile Val Val Arg Lys 
                245                 250                 255     


Glu Glu Gly Phe Thr His Ile Leu Leu Ser Ser Gln Thr Ser Asp Asn 
            260                 265                 270         


Asn Ala Leu Thr Pro Glu Ile Met Lys Glu Val Arg Arg Ala Leu Cys 
        275                 280                 285             


Asn Ala Ala Thr Asp Asp Ser Lys Leu Leu Leu Leu Ser Ala Val Gly 
    290                 295                 300                 


Ser Val Phe Cys Ser Gly Leu Asp Tyr Ser Tyr Leu Ile Gly Arg Leu 
305                 310                 315                 320 


Ser Ser Asp Arg Arg Lys Glu Ser Thr Arg Ile Ala Glu Ala Ile Arg 
                325                 330                 335     


Asp Phe Val Lys Ala Phe Ile Gln Phe Lys Lys Pro Ile Val Val Ala 
            340                 345                 350         


Ile Asn Gly Pro Ala Leu Gly Leu Gly Ala Ser Ile Leu Pro Leu Cys 
        355                 360                 365             


Asp Ile Val Trp Ala Ser Glu Lys Ala Trp Phe Gln Thr Pro Tyr Ala 
    370                 375                 380                 


Thr Ile Arg Leu Thr Pro Ala Gly Cys Ser Ser Tyr Thr Phe Pro Gln 
385                 390                 395                 400 


Ile Leu Gly Val Ala Leu Ala Asn Glu Met Leu Phe Cys Gly Arg Lys 
                405                 410                 415     


Leu Thr Ala Gln Glu Ala Cys Ser Arg Gly Leu Val Ser Gln Val Phe 
            420                 425                 430         


Trp Pro Thr Thr Phe Ser Gln Glu Val Met Leu Arg Val Lys Glu Met 
        435                 440                 445             


Ala Ser Cys Ser Ala Val Val Leu Glu Glu Ser Lys Cys Leu Val Arg 
    450                 455                 460                 


Ser Phe Leu Lys Ser Val Leu Glu Asp Val Asn Glu Lys Glu Cys Leu 
465                 470                 475                 480 


Met Leu Lys Gln Leu Trp Ser Ser Ser Lys Gly Leu Asp Ser Leu Phe 
                485                 490                 495     


Ser Tyr Leu Gln Asp Lys Ile Tyr Glu Val 
            500                 505     


<210>  1979
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDYL__Homo_sapiens__NP_001137442

<400>  1979

Met Asp Leu Ala Lys Ser Gly Ile Lys Ile Leu Val Pro Lys Ser Pro 
1               5                   10                  15      


Val Lys Ser Arg Thr Ala Val Asp Gly Phe Gln Ser Glu Ser Pro Glu 
            20                  25                  30          


Lys Leu Asp Pro Val Glu Gln Gly Gln Glu Asp Thr Val Ala Pro Glu 
        35                  40                  45              


Val Ala Ala Glu Lys Pro Val Gly Ala Leu Leu Gly Pro Gly Ala Glu 
    50                  55                  60                  


Arg Ala Arg Met Gly Ser Arg Pro Arg Ile His Pro Leu Val Pro Gln 
65                  70                  75                  80  


Val Pro Gly Pro Val Thr Ala Ala Met Ala Thr Gly Leu Ala Val Asn 
                85                  90                  95      


Gly Lys Gly Thr Ser Pro Phe Met Asp Ala Leu Thr Ala Asn Gly Thr 
            100                 105                 110         


Thr Asn Ile Gln Thr Ser Val Thr Gly Val Thr Ala Ser Lys Arg Lys 
        115                 120                 125             


Phe Ile Asp Asp Arg Arg Asp Gln Pro Phe Asp Lys Arg Leu Arg Phe 
    130                 135                 140                 


Ser Val Arg Gln Thr Glu Ser Ala Tyr Arg Tyr Arg Asp Ile Val Val 
145                 150                 155                 160 


Arg Lys Gln Asp Gly Phe Thr His Ile Leu Leu Ser Thr Lys Ser Ser 
                165                 170                 175     


Glu Asn Asn Ser Leu Asn Pro Glu Val Met Arg Glu Val Gln Ser Ala 
            180                 185                 190         


Leu Ser Thr Ala Ala Ala Asp Asp Ser Lys Leu Val Leu Leu Ser Ala 
        195                 200                 205             


Val Gly Ser Val Phe Cys Cys Gly Leu Asp Phe Ile Tyr Phe Ile Arg 
    210                 215                 220                 


Arg Leu Thr Asp Asp Arg Lys Arg Glu Ser Thr Lys Met Ala Glu Ala 
225                 230                 235                 240 


Ile Arg Asn Phe Val Asn Thr Phe Ile Gln Phe Lys Lys Pro Ile Ile 
                245                 250                 255     


Val Ala Val Asn Gly Pro Ala Ile Gly Leu Gly Ala Ser Ile Leu Pro 
            260                 265                 270         


Leu Cys Asp Val Val Trp Ala Asn Glu Lys Ala Trp Phe Gln Thr Pro 
        275                 280                 285             


Tyr Thr Thr Phe Gly Gln Ser Pro Asp Gly Cys Ser Thr Val Met Phe 
    290                 295                 300                 


Pro Lys Ile Met Gly Gly Ala Ser Ala Asn Glu Met Leu Leu Ser Gly 
305                 310                 315                 320 


Arg Lys Leu Thr Ala Gln Glu Ala Cys Gly Lys Gly Leu Val Ser Gln 
                325                 330                 335     


Val Phe Trp Pro Gly Thr Phe Thr Gln Glu Val Met Val Arg Ile Lys 
            340                 345                 350         


Glu Leu Ala Ser Cys Asn Pro Val Val Leu Glu Glu Ser Lys Ala Leu 
        355                 360                 365             


Val Arg Cys Asn Met Lys Met Glu Leu Glu Gln Ala Asn Glu Arg Glu 
    370                 375                 380                 


Cys Glu Val Leu Lys Lys Ile Trp Gly Ser Ala Gln Gly Met Asp Ser 
385                 390                 395                 400 


Met Leu Lys Tyr Leu Gln Arg Lys Ile Asp Glu Phe 
                405                 410         


<210>  1980
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM16__Homo_sapiens__NP_001034302

<400>  1980

Met Ala Leu Thr Gly Tyr Ser Trp Leu Leu Leu Ser Ala Thr Phe Leu 
1               5                   10                  15      


Asn Val Gly Ala Glu Ile Ser Ile Thr Leu Glu Pro Ala Gln Pro Ser 
            20                  25                  30          


Glu Gly Asp Asn Val Thr Leu Val Val His Gly Leu Ser Gly Glu Leu 
        35                  40                  45              


Leu Ala Tyr Ser Trp Tyr Ala Gly Pro Thr Leu Ser Val Ser Tyr Leu 
    50                  55                  60                  


Val Ala Ser Tyr Ile Val Ser Thr Gly Asp Glu Thr Pro Gly Pro Ala 
65                  70                  75                  80  


His Thr Gly Arg Glu Ala Val Arg Pro Asp Gly Ser Leu Asp Ile Gln 
                85                  90                  95      


Gly Ile Leu Pro Arg His Ser Gly Thr Tyr Ile Leu Gln Thr Phe Asn 
            100                 105                 110         


Arg Gln Leu Gln Thr Glu Val Gly Tyr Gly His Val Gln Val His Glu 
        115                 120                 125             


Ile Leu Ala Gln Pro Thr Val Leu Ala Asn Ser Thr Ala Leu Val Glu 
    130                 135                 140                 


Arg Arg Asp Thr Leu Arg Leu Met Cys Ser Ser Pro Ser Pro Thr Ala 
145                 150                 155                 160 


Glu Val Arg Trp Phe Phe Asn Gly Gly Ala Leu Pro Val Ala Leu Arg 
                165                 170                 175     


Leu Gly Leu Ser Pro Asp Gly Arg Val Leu Ala Arg His Gly Ile Arg 
            180                 185                 190         


Arg Glu Glu Ala Gly Ala Tyr Gln Cys Glu Val Trp Asn Pro Val Ser 
        195                 200                 205             


Val Ser Arg Ser Glu Pro Ile Asn Leu Thr Val Tyr Phe Gly Pro Glu 
    210                 215                 220                 


Arg Val Ala Ile Leu Gln Asp Ser Thr Thr Arg Thr Gly Cys Thr Ile 
225                 230                 235                 240 


Lys Val Asp Phe Asn Thr Ser Leu Thr Leu Trp Cys Val Ser Arg Ser 
                245                 250                 255     


Cys Pro Glu Pro Glu Tyr Val Trp Thr Phe Asn Gly Gln Ala Leu Lys 
            260                 265                 270         


Asn Gly Gln Asp His Leu Asn Ile Ser Ser Met Thr Ala Ala Gln Glu 
        275                 280                 285             


Gly Thr Tyr Thr Cys Ile Ala Lys Asn Thr Lys Thr Leu Leu Ser Gly 
    290                 295                 300                 


Ser Ala Ser Val Val Val Lys Leu Ser Ala Ala Ala Val Ala Thr Met 
305                 310                 315                 320 


Ile Val Pro Val Pro Thr Lys Pro Thr Glu Gly Gln Asp Val Thr Leu 
                325                 330                 335     


Thr Val Gln Gly Tyr Pro Lys Asp Leu Leu Val Tyr Ala Trp Tyr Arg 
            340                 345                 350         


Gly Pro Ala Ser Glu Pro Asn Arg Leu Leu Ser Gln Leu Pro Ser Gly 
        355                 360                 365             


Thr Trp Ile Ala Gly Pro Ala His Thr Gly Arg Glu Val Gly Phe Pro 
    370                 375                 380                 


Asn Cys Ser Leu Leu Val Gln Lys Leu Asn Leu Thr Asp Thr Gly Arg 
385                 390                 395                 400 


Tyr Thr Leu Lys Thr Val Thr Val Gln Gly Lys Thr Glu Thr Leu Glu 
                405                 410                 415     


Val Glu Leu Gln Val Ala Pro Leu Gly 
            420                 425 


<210>  1981
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM19__Homo_sapiens__NP_001121365

<400>  1981

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val Pro Asp Thr Phe Gln Asp Phe Asn 
    50                  55                  60                  


Trp Tyr Leu Gly Glu Glu Thr Tyr Gly Gly Thr Arg Leu Phe Thr Tyr 
65                  70                  75                  80  


Ile Pro Gly Ile Gln Arg Pro Gln Arg Asp Gly Ser Ala Met Gly Gln 
                85                  90                  95      


Arg Asp Ile Val Gly Phe Pro Asn Gly Ser Met Leu Leu Arg Arg Ala 
            100                 105                 110         


Gln Pro Thr Asp Ser Gly Thr Tyr Gln Val Ala Ile Thr Ile Asn Ser 
        115                 120                 125             


Glu Trp Thr Met Lys Ala Lys Thr Glu Val Gln Val Ala Glu Lys Asn 
    130                 135                 140                 


Lys Glu Leu Pro Ser Thr His Leu Pro Thr Asn Ala Gly Ile Leu Ala 
145                 150                 155                 160 


Ala Thr Ile Ile Gly Ser Leu Ala Ala Gly Ala Leu Leu Ile Ser Cys 
                165                 170                 175     


Ile Ala Tyr Leu Leu Val Thr Arg Asn Trp Arg Gly Gln Ser His Arg 
            180                 185                 190         


Leu Pro Ala Pro Arg Gly Gln Gly Ser Leu Ser Ile Leu Cys Ser Ala 
        195                 200                 205             


Val Ser Pro Val Pro Ser Val Thr Pro Ser Thr Trp Met Ala Thr Thr 
    210                 215                 220                 


Glu Lys Pro Glu Leu Gly Pro Ala His Asp Ala Gly Asp Asn Asn Ile 
225                 230                 235                 240 


Tyr Glu Val Met Pro Ser Pro Val Leu Leu Val Ser Pro Ile Ser Asp 
                245                 250                 255     


Thr Arg Ser Ile Asn Pro Ala Arg Pro Leu Pro Thr Pro Pro His Leu 
            260                 265                 270         


Gln Ala Glu Pro Glu Asn His Gln Tyr Gln Asp Leu Leu Asn Pro Asp 
        275                 280                 285             


Pro Ala Pro Tyr Cys Gln Leu Val Pro Thr Ser 
    290                 295                 


<210>  1982
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM1__Homo_sapiens__NP_001020083

<400>  1982

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 


<210>  1983
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM21__Homo_sapiens__XP_006725457

<400>  1983

Met Gly Pro Pro Ser Ala Cys Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Ala Pro Thr 
            20                  25                  30          


Thr Ala Trp Leu Phe Ile Ala Ser Ala Pro Phe Glu Val Ala Glu Gly 
        35                  40                  45              


Glu Asn Val His Leu Ser Val Val Tyr Leu Pro Glu Asn Leu Tyr Ser 
    50                  55                  60                  


Tyr Gly Trp Tyr Lys Gly Lys Thr Val Glu Pro Asn Gln Leu Ile Ala 
65                  70                  75                  80  


Ala Tyr Val Ile Asp Thr His Val Arg Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Ser Pro Ser Gly Asp Leu His Phe Gln Asn Val 
            100                 105                 110         


Thr Leu Glu Asp Thr Gly Tyr Tyr Asn Leu Gln Val Thr Tyr Arg Asn 
        115                 120                 125             


Ser Gln Ile Glu Gln Ala Ser His His Leu Arg Val Tyr Glu Ser Val 
    130                 135                 140                 


Ala Gln Pro Ser Ile Gln Ala Ser Ser Thr Thr Val Thr Glu Lys Gly 
145                 150                 155                 160 


Ser Val Val Leu Thr Cys His Thr Asn Asn Thr Gly Thr Ser Phe Gln 
                165                 170                 175     


Trp Ile Phe Asn Asn Gln Arg Leu Gln Val Thr Lys Arg Met Lys Leu 
            180                 185                 190         


Ser Trp Phe Asn His Val Leu Thr Ile Asp Pro Ile Arg Gln Glu Asp 
        195                 200                 205             


Ala Gly Glu Tyr Gln Cys Glu Val Ser Asn Pro Val Ser Ser Asn Arg 
    210                 215                 220                 


Ser Asp Pro Leu Lys Leu Thr Val Lys Ser Asp Asp Asn Thr Leu Gly 
225                 230                 235                 240 


Ile Leu Ile Gly Val Leu Val Gly Ser Leu Leu Val Ala Ala Leu Val 
                245                 250                 255     


Cys Phe Leu Leu Leu Arg Lys Thr Gly Arg Ala Ser Asp Gln Ser Asp 
            260                 265                 270         


Phe Arg Glu Gln Gln Pro Pro Ala Ser Thr Pro Gly His Gly Pro Ser 
        275                 280                 285             


Asp Ser Ser Ile Ser 
    290             


<210>  1984
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM3__Homo_sapiens__NP_001264092

<400>  1984

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 
    130                 135                 140                 


Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ala Lys Thr Gly Arg Pro Trp Ser Leu Pro Gln Leu Cys Leu Leu Asp 
            180                 185                 190         


Val Pro Ser Leu His Cys Pro Gly Pro Pro Thr Gln Pro Gln Asp Ser 
        195                 200                 205             


Ser Phe His Leu 
    210         


<210>  1985
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM4__Homo_sapiens__NP_001808

<400>  1985

Met Gly Pro Pro Ser Ala Ala Pro Arg Gly Gly His Arg Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Ile Thr Ala Ser Leu Leu Thr Phe Trp His Pro Pro Thr 
            20                  25                  30          


Thr Val Gln Phe Thr Ile Glu Ala Leu Pro Ser Ser Ala Ala Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Ala Cys Asn Ile Ser Glu Thr Ile Gln Ala 
    50                  55                  60                  


Tyr Tyr Trp His Lys Gly Lys Thr Ala Glu Gly Ser Pro Leu Ile Ala 
65                  70                  75                  80  


Gly Tyr Ile Thr Asp Ile Gln Ala Asn Ile Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Val Tyr Pro Asn Gly Ser Leu Leu Phe Gln Asn Ile 
            100                 105                 110         


Thr Leu Glu Asp Ala Gly Ser Tyr Thr Leu Arg Thr Ile Asn Ala Ser 
        115                 120                 125             


Tyr Asp Ser Asp Gln Ala Thr Gly Gln Leu His Val His Gln Asn Asn 
    130                 135                 140                 


Val Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ser Arg Thr Gly Arg Ala Ser Ile Gln Arg Asp Leu Arg Glu Gln Pro 
            180                 185                 190         


Pro Pro Ala Ser Thr Pro Gly His Gly Pro Ser His Arg Ser Thr Phe 
        195                 200                 205             


Ser Ala Pro Leu Pro Ser Pro Arg Thr Ala Thr Pro Ile Tyr Glu Glu 
    210                 215                 220                 


Leu Leu Tyr Ser Asp Ala Asn Ile Tyr Cys Gln Ile Asp His Lys Ala 
225                 230                 235                 240 


Asp Val Val Ser 
                


<210>  1986
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM5__Homo_sapiens__NP_001278413

<400>  1986

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  1987
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM6__Homo_sapiens__NP_002474

<400>  1987

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  1988
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM7__Homo_sapiens__NP_001278414

<400>  1988

Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn 
            20                  25                  30          


Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His 
                85                  90                  95      


Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn 
            100                 105                 110         


Val Thr His Asn Asp Ala Gly Ile Tyr Thr Leu His Val Ile Lys Glu 
        115                 120                 125             


Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu 
    130                 135                 140                 


Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn 
145                 150                 155                 160 


Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr 
                165                 170                 175     


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu 
            180                 185                 190         


Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys 
        195                 200                 205             


Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala 
    210                 215                 220                 


Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln 
225                 230                 235                 240 


Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile 
                245                 250                 255     


Gly Val Leu Ala Gly Met Ala Leu Ile 
            260                 265 


<210>  1989
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM8__Homo_sapiens__NP_001807

<400>  1989

Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val 
            100                 105                 110         


Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn 
        115                 120                 125             


Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser 
    290                 295                 300                 


Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp 
305                 310                 315                 320 


Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val 
                325                 330                 335     


Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile 
            340                 345                 


<210>  1990
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEBPA__Homo_sapiens__NP_001274353

<400>  1990

Met Arg Gly Arg Gly Arg Ala Gly Ser Pro Gly Gly Arg Arg Arg Arg 
1               5                   10                  15      


Pro Ala Gln Ala Gly Gly Arg Arg Gly Ser Pro Cys Arg Glu Asn Ser 
            20                  25                  30          


Asn Ser Pro Met Glu Ser Ala Asp Phe Tyr Glu Ala Glu Pro Arg Pro 
        35                  40                  45              


Pro Met Ser Ser His Leu Gln Ser Pro Pro His Ala Pro Ser Ser Ala 
    50                  55                  60                  


Ala Phe Gly Phe Pro Arg Gly Ala Gly Pro Ala Gln Pro Pro Ala Pro 
65                  70                  75                  80  


Pro Ala Ala Pro Glu Pro Leu Gly Gly Ile Cys Glu His Glu Thr Ser 
                85                  90                  95      


Ile Asp Ile Ser Ala Tyr Ile Asp Pro Ala Ala Phe Asn Asp Glu Phe 
            100                 105                 110         


Leu Ala Asp Leu Phe Gln His Ser Arg Gln Gln Glu Lys Ala Lys Ala 
        115                 120                 125             


Ala Val Gly Pro Thr Gly Gly Gly Gly Gly Gly Asp Phe Asp Tyr Pro 
    130                 135                 140                 


Gly Ala Pro Ala Gly Pro Gly Gly Ala Val Met Pro Gly Gly Ala His 
145                 150                 155                 160 


Gly Pro Pro Pro Gly Tyr Gly Cys Ala Ala Ala Gly Tyr Leu Asp Gly 
                165                 170                 175     


Arg Leu Glu Pro Leu Tyr Glu Arg Val Gly Ala Pro Ala Leu Arg Pro 
            180                 185                 190         


Leu Val Ile Lys Gln Glu Pro Arg Glu Glu Asp Glu Ala Lys Gln Leu 
        195                 200                 205             


Ala Leu Ala Gly Leu Phe Pro Tyr Gln Pro Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 


Ser His Pro His Pro His Pro Pro Pro Ala His Leu Ala Ala Pro His 
225                 230                 235                 240 


Leu Gln Phe Gln Ile Ala His Cys Gly Gln Thr Thr Met His Leu Gln 
                245                 250                 255     


Pro Gly His Pro Thr Pro Pro Pro Thr Pro Val Pro Ser Pro His Pro 
            260                 265                 270         


Ala Pro Ala Leu Gly Ala Ala Gly Leu Pro Gly Pro Gly Ser Ala Leu 
        275                 280                 285             


Lys Gly Leu Gly Ala Ala His Pro Asp Leu Arg Ala Ser Gly Gly Ser 
    290                 295                 300                 


Gly Ala Gly Lys Ala Lys Lys Ser Val Asp Lys Asn Ser Asn Glu Tyr 
305                 310                 315                 320 


Arg Val Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp 
                325                 330                 335     


Lys Ala Lys Gln Arg Asn Val Glu Thr Gln Gln Lys Val Leu Glu Leu 
            340                 345                 350         


Thr Ser Asp Asn Asp Arg Leu Arg Lys Arg Val Glu Gln Leu Ser Arg 
        355                 360                 365             


Glu Leu Asp Thr Leu Arg Gly Ile Phe Arg Gln Leu Pro Glu Ser Ser 
    370                 375                 380                 


Leu Val Lys Ala Met Gly Asn Cys Ala 
385                 390             


<210>  1991
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEBPB__Homo_sapiens__NP_005185

<400>  1991

Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Ala Arg Pro Gly Pro Arg Pro Pro Ala Gly Glu Leu Gly 
    50                  55                  60                  


Ser Ile Gly Asp His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
65                  70                  75                  80  


Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Ala Thr Ala Thr Asp Thr 
                85                  90                  95      


Phe Glu Ala Ala Pro Pro Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly 
            100                 105                 110         


Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
        115                 120                 125             


Lys Asn Cys Lys Lys Pro Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
    130                 135                 140                 


Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
145                 150                 155                 160 


His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                165                 170                 175     


Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
            180                 185                 190         


Pro Gly Gly Gly Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg 
        195                 200                 205             


Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu 
    210                 215                 220                 


Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala Asp 
225                 230                 235                 240 


Ala Lys Ala Pro Pro Thr Ala Cys Tyr Ala Gly Ala Ala Pro Ala Pro 
                245                 250                 255     


Ser Gln Val Lys Ser Lys Ala Lys Lys Thr Val Asp Lys His Ser Asp 
            260                 265                 270         


Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        275                 280                 285             


Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
    290                 295                 300                 


Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
305                 310                 315                 320 


Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
                325                 330                 335     


Pro Leu Leu Ala Ser Ser Gly His Cys 
            340                 345 


<210>  1992
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEBPD__Homo_sapiens__NP_005186

<400>  1992

Met Ser Ala Ala Leu Phe Ser Leu Asp Gly Pro Ala Arg Gly Ala Pro 
1               5                   10                  15      


Trp Pro Ala Glu Pro Ala Pro Phe Tyr Glu Pro Gly Arg Ala Gly Lys 
            20                  25                  30          


Pro Gly Arg Gly Ala Glu Pro Gly Ala Leu Gly Glu Pro Gly Ala Ala 
        35                  40                  45              


Ala Pro Ala Met Tyr Asp Asp Glu Ser Ala Ile Asp Phe Ser Ala Tyr 
    50                  55                  60                  


Ile Asp Ser Met Ala Ala Val Pro Thr Leu Glu Leu Cys His Asp Glu 
65                  70                  75                  80  


Leu Phe Ala Asp Leu Phe Asn Ser Asn His Lys Ala Gly Gly Ala Gly 
                85                  90                  95      


Pro Leu Glu Leu Leu Pro Gly Gly Pro Ala Arg Pro Leu Gly Pro Gly 
            100                 105                 110         


Pro Ala Ala Pro Arg Leu Leu Lys Arg Glu Pro Asp Trp Gly Asp Gly 
        115                 120                 125             


Asp Ala Pro Gly Ser Leu Leu Pro Ala Gln Val Ala Ala Cys Ala Gln 
    130                 135                 140                 


Thr Val Val Ser Leu Ala Ala Ala Gly Gln Pro Thr Pro Pro Thr Ser 
145                 150                 155                 160 


Pro Glu Pro Pro Arg Ser Ser Pro Arg Gln Thr Pro Ala Pro Gly Pro 
                165                 170                 175     


Ala Arg Glu Lys Ser Ala Gly Lys Arg Gly Pro Asp Arg Gly Ser Pro 
            180                 185                 190         


Glu Tyr Arg Gln Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        195                 200                 205             


Arg Asp Lys Ala Lys Arg Arg Asn Gln Glu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Glu Leu Ser Ala Glu Asn Glu Lys Leu His Gln Arg Val Glu Gln Leu 
225                 230                 235                 240 


Thr Arg Asp Leu Ala Gly Leu Arg Gln Phe Phe Lys Gln Leu Pro Ser 
                245                 250                 255     


Pro Pro Phe Leu Pro Ala Ala Gly Thr Ala Asp Cys Arg 
            260                 265                 


<210>  1993
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEBPE__Homo_sapiens__NP_001796

<400>  1993

Met Ser His Gly Thr Tyr Tyr Glu Cys Glu Pro Arg Gly Gly Gln Gln 
1               5                   10                  15      


Pro Leu Glu Phe Ser Gly Gly Arg Ala Gly Pro Gly Glu Leu Gly Asp 
            20                  25                  30          


Met Cys Glu His Glu Ala Ser Ile Asp Leu Ser Ala Tyr Ile Glu Ser 
        35                  40                  45              


Gly Glu Glu Gln Leu Leu Ser Asp Leu Phe Ala Val Lys Pro Ala Pro 
    50                  55                  60                  


Glu Ala Arg Gly Leu Lys Gly Pro Gly Thr Pro Ala Phe Pro His Tyr 
65                  70                  75                  80  


Leu Pro Pro Asp Pro Arg Pro Phe Ala Tyr Pro Pro His Thr Phe Gly 
                85                  90                  95      


Pro Asp Arg Lys Ala Leu Gly Pro Gly Ile Tyr Ser Ser Pro Gly Ser 
            100                 105                 110         


Tyr Asp Pro Arg Ala Val Ala Val Lys Glu Glu Pro Arg Gly Pro Glu 
        115                 120                 125             


Gly Ser Arg Ala Ala Ser Arg Gly Ser Tyr Asn Pro Leu Gln Tyr Gln 
    130                 135                 140                 


Val Ala His Cys Gly Gln Thr Ala Met His Leu Pro Pro Thr Leu Ala 
145                 150                 155                 160 


Ala Pro Gly Gln Pro Leu Arg Val Leu Lys Ala Pro Leu Ala Thr Ala 
                165                 170                 175     


Ala Pro Pro Cys Ser Pro Leu Leu Lys Ala Pro Ser Pro Ala Gly Pro 
            180                 185                 190         


Leu His Lys Gly Lys Lys Ala Val Asn Lys Asp Ser Leu Glu Tyr Arg 
        195                 200                 205             


Leu Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg Asp Lys 
    210                 215                 220                 


Ala Lys Arg Arg Ile Leu Glu Thr Gln Gln Lys Val Leu Glu Tyr Met 
225                 230                 235                 240 


Ala Glu Asn Glu Arg Leu Arg Ser Arg Val Glu Gln Leu Thr Gln Glu 
                245                 250                 255     


Leu Asp Thr Leu Arg Asn Leu Phe Arg Gln Ile Pro Glu Ala Ala Asn 
            260                 265                 270         


Leu Ile Lys Gly Val Gly Gly Cys Ser 
        275                 280     


<210>  1994
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEBPG__Homo_sapiens__NP_001239225

<400>  1994

Met Ser Lys Ile Ser Gln Gln Asn Ser Thr Pro Gly Val Asn Gly Ile 
1               5                   10                  15      


Ser Val Ile His Thr Gln Ala His Ala Ser Gly Leu Gln Gln Val Pro 
            20                  25                  30          


Gln Leu Val Pro Ala Gly Pro Gly Gly Gly Gly Lys Ala Val Ala Pro 
        35                  40                  45              


Ser Lys Gln Ser Lys Lys Ser Ser Pro Met Asp Arg Asn Ser Asp Glu 
    50                  55                  60                  


Tyr Arg Gln Arg Arg Glu Arg Asn Asn Met Ala Val Lys Lys Ser Arg 
65                  70                  75                  80  


Leu Lys Ser Lys Gln Lys Ala Gln Asp Thr Leu Gln Arg Val Asn Gln 
                85                  90                  95      


Leu Lys Glu Glu Asn Glu Arg Leu Glu Ala Lys Ile Lys Leu Leu Thr 
            100                 105                 110         


Lys Glu Leu Ser Val Leu Lys Asp Leu Phe Leu Glu His Ala His Asn 
        115                 120                 125             


Leu Ala Asp Asn Val Gln Ser Ile Ser Thr Glu Asn Thr Thr Ala Asp 
    130                 135                 140                 


Gly Asp Asn Ala Gly Gln 
145                 150 


<210>  1995
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEBPZ__Homo_sapiens__NP_005751

<400>  1995

Met Ala Ala Val Lys Glu Pro Leu Glu Phe His Ala Lys Arg Pro Trp 
1               5                   10                  15      


Arg Pro Glu Glu Ala Val Glu Asp Pro Asp Glu Glu Asp Glu Asp Asn 
            20                  25                  30          


Thr Ser Glu Ala Glu Asn Gly Phe Ser Leu Glu Glu Val Leu Arg Leu 
        35                  40                  45              


Gly Gly Thr Lys Gln Asp Tyr Leu Met Leu Ala Thr Leu Asp Glu Asn 
    50                  55                  60                  


Glu Glu Val Ile Asp Gly Gly Lys Lys Gly Ala Ile Asp Asp Leu Gln 
65                  70                  75                  80  


Gln Gly Glu Leu Glu Ala Phe Ile Gln Asn Leu Asn Leu Ala Lys Tyr 
                85                  90                  95      


Thr Lys Ala Ser Leu Val Glu Glu Asp Glu Pro Ala Glu Lys Glu Asn 
            100                 105                 110         


Ser Ser Lys Lys Glu Val Lys Ile Pro Lys Ile Asn Asn Lys Asn Thr 
        115                 120                 125             


Ala Glu Ser Gln Arg Thr Ser Val Asn Lys Val Lys Asn Lys Asn Arg 
    130                 135                 140                 


Pro Glu Pro His Ser Asp Glu Asn Gly Ser Thr Thr Pro Lys Val Lys 
145                 150                 155                 160 


Lys Asp Lys Gln Asn Ile Phe Glu Phe Phe Glu Arg Gln Thr Leu Leu 
                165                 170                 175     


Leu Arg Pro Gly Gly Lys Trp Tyr Asp Leu Glu Tyr Ser Asn Glu Tyr 
            180                 185                 190         


Ser Leu Lys Pro Gln Pro Gln Asp Val Val Ser Lys Tyr Lys Thr Leu 
        195                 200                 205             


Ala Gln Lys Leu Tyr Gln His Glu Ile Asn Leu Phe Lys Ser Lys Thr 
    210                 215                 220                 


Asn Ser Gln Lys Gly Ala Ser Ser Thr Trp Met Lys Ala Ile Val Ser 
225                 230                 235                 240 


Ser Gly Thr Leu Gly Asp Arg Met Ala Ala Met Ile Leu Leu Ile Gln 
                245                 250                 255     


Asp Asp Ala Val His Thr Leu Gln Phe Val Glu Thr Leu Val Asn Leu 
            260                 265                 270         


Val Lys Lys Lys Gly Ser Lys Gln Gln Cys Leu Met Ala Leu Asp Thr 
        275                 280                 285             


Phe Lys Glu Leu Leu Ile Thr Asp Leu Leu Pro Asp Asn Arg Lys Leu 
    290                 295                 300                 


Arg Ile Phe Ser Gln Arg Pro Phe Asp Lys Leu Glu Gln Leu Ser Ser 
305                 310                 315                 320 


Gly Asn Lys Asp Ser Arg Asp Arg Arg Leu Ile Leu Trp Tyr Phe Glu 
                325                 330                 335     


His Gln Leu Lys His Leu Val Ala Glu Phe Val Gln Val Leu Glu Thr 
            340                 345                 350         


Leu Ser His Asp Thr Leu Val Thr Thr Lys Thr Arg Ala Leu Thr Val 
        355                 360                 365             


Ala His Glu Leu Leu Cys Asn Lys Pro Glu Glu Glu Lys Ala Leu Leu 
    370                 375                 380                 


Val Gln Val Val Asn Lys Leu Gly Asp Pro Gln Asn Arg Ile Ala Thr 
385                 390                 395                 400 


Lys Ala Ser His Leu Leu Glu Thr Leu Leu Cys Lys His Pro Asn Met 
                405                 410                 415     


Lys Gly Val Val Ser Gly Glu Val Glu Arg Leu Leu Phe Arg Ser Asn 
            420                 425                 430         


Ile Ser Ser Lys Ala Gln Tyr Tyr Ala Ile Cys Phe Leu Asn Gln Met 
        435                 440                 445             


Ala Leu Ser His Glu Glu Ser Glu Leu Ala Asn Lys Leu Ile Thr Val 
    450                 455                 460                 


Tyr Phe Cys Phe Phe Arg Thr Cys Val Lys Lys Lys Asp Val Glu Ser 
465                 470                 475                 480 


Lys Met Leu Ser Ala Leu Leu Thr Gly Val Asn Arg Ala Tyr Pro Tyr 
                485                 490                 495     


Ser Gln Thr Gly Asp Asp Lys Val Arg Glu Gln Ile Asp Thr Leu Phe 
            500                 505                 510         


Lys Val Leu His Ile Val Asn Phe Asn Thr Ser Val Gln Ala Leu Met 
        515                 520                 525             


Leu Leu Phe Gln Val Met Asn Ser Gln Gln Thr Ile Ser Asp Arg Tyr 
    530                 535                 540                 


Tyr Thr Ala Leu Tyr Arg Lys Met Leu Asp Pro Gly Leu Met Thr Cys 
545                 550                 555                 560 


Ser Lys Gln Ala Met Phe Leu Asn Leu Val Tyr Lys Ser Leu Lys Ala 
                565                 570                 575     


Asp Ile Val Leu Arg Arg Val Lys Ala Phe Val Lys Arg Leu Leu Gln 
            580                 585                 590         


Val Thr Cys Gln Gln Met Pro Pro Phe Ile Cys Gly Ala Leu Tyr Leu 
        595                 600                 605             


Val Ser Glu Ile Leu Lys Ala Lys Pro Gly Leu Arg Ser Gln Leu Asp 
    610                 615                 620                 


Asp His Pro Glu Ser Asp Asp Glu Glu Asn Phe Ile Asp Ala Asn Asp 
625                 630                 635                 640 


Asp Glu Asp Met Glu Lys Phe Thr Asp Ala Asp Lys Glu Thr Glu Ile 
                645                 650                 655     


Val Lys Lys Leu Glu Thr Glu Glu Thr Val Pro Glu Thr Asp Val Glu 
            660                 665                 670         


Thr Lys Lys Pro Glu Val Ala Ser Trp Val His Phe Asp Asn Leu Lys 
        675                 680                 685             


Gly Gly Lys Gln Leu Asn Lys Tyr Asp Pro Phe Ser Arg Asn Pro Leu 
    690                 695                 700                 


Phe Cys Gly Ala Glu Asn Thr Ser Leu Trp Glu Leu Lys Lys Leu Ser 
705                 710                 715                 720 


Val His Phe His Pro Ser Val Ala Leu Phe Ala Lys Thr Ile Leu Gln 
                725                 730                 735     


Gly Asn Tyr Ile Gln Tyr Ser Gly Asp Pro Leu Gln Asp Phe Thr Leu 
            740                 745                 750         


Met Arg Phe Leu Asp Arg Phe Val Tyr Arg Asn Pro Lys Pro His Lys 
        755                 760                 765             


Gly Lys Glu Asn Thr Asp Ser Val Val Met Gln Pro Lys Arg Lys His 
    770                 775                 780                 


Phe Ile Lys Asp Ile Arg His Leu Pro Val Asn Ser Lys Glu Phe Leu 
785                 790                 795                 800 


Ala Lys Glu Glu Ser Gln Ile Pro Val Asp Glu Val Phe Phe His Arg 
                805                 810                 815     


Tyr Tyr Lys Lys Val Ala Val Lys Glu Lys Gln Lys Arg Asp Ala Asp 
            820                 825                 830         


Glu Glu Ser Ile Glu Asp Val Asp Asp Glu Glu Phe Glu Glu Leu Ile 
        835                 840                 845             


Asp Thr Phe Glu Asp Asp Asn Cys Phe Ser Ser Gly Lys Asp Asp Met 
    850                 855                 860                 


Asp Phe Ala Gly Asn Val Lys Lys Arg Thr Lys Gly Ala Lys Asp Asn 
865                 870                 875                 880 


Thr Leu Asp Glu Asp Ser Glu Gly Ser Asp Asp Glu Leu Gly Asn Leu 
                885                 890                 895     


Asp Asp Asp Glu Val Ser Leu Gly Ser Met Asp Asp Glu Glu Phe Ala 
            900                 905                 910         


Glu Val Asp Glu Asp Gly Gly Thr Phe Met Asp Val Leu Asp Asp Glu 
        915                 920                 925             


Ser Glu Ser Val Pro Glu Leu Glu Val His Ser Lys Val Ser Thr Lys 
    930                 935                 940                 


Lys Ser Lys Arg Lys Gly Thr Asp Asp Phe Asp Phe Ala Gly Ser Phe 
945                 950                 955                 960 


Gln Gly Pro Arg Lys Lys Lys Arg Asn Leu Asn Asp Ser Ser Leu Phe 
                965                 970                 975     


Val Ser Ala Glu Glu Phe Gly His Leu Leu Asp Glu Asn Met Gly Ser 
            980                 985                 990         


Lys Phe Asp Asn Ile Gly Met Asn  Ala Met Ala Asn Lys  Asp Asn Ala 
        995                 1000                 1005             


Ser Leu  Lys Gln Leu Arg Trp  Glu Ala Glu Arg Asp  Asp Trp Leu 
    1010                 1015                 1020             


His Asn  Arg Asp Ala Lys Ser  Ile Ile Lys Lys Lys  Lys His Phe 
    1025                 1030                 1035             


Lys Lys  Lys Arg Ile Lys Thr  Thr Gln Lys Thr Lys  Lys Gln Arg 
    1040                 1045                 1050             


Lys 
    


<210>  1996
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CECR1__Homo_sapiens__NP_803124

<400>  1996

Met Asp Ser Leu Glu Trp Asn Trp Ala Leu Val Tyr Glu Leu Ser Gly 
1               5                   10                  15      


Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val Ala 
            20                  25                  30          


Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile Ile 
        35                  40                  45              


Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser Ile 
    50                  55                  60                  


Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala Gly 
65                  70                  75                  80  


Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp Tyr 
                85                  90                  95      


Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro Tyr 
            100                 105                 110         


Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp Arg 
        115                 120                 125             


Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His Gly 
    130                 135                 140                 


Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys Lys 
145                 150                 155                 160 


Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys Leu 
                165                 170                 175     


Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr Gly 
            180                 185                 190         


His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala Lys 
        195                 200                 205             


Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly Met 
    210                 215                 220                 


Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile Lys 
225                 230                 235                 240 


Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile Trp 
                245                 250                 255     


Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            260                 265                 270 


<210>  1997
<211>  1464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CECR2__Homo_sapiens__NP_001276976

<400>  1997

Met Cys Pro Glu Glu Gly Gly Ala Ala Gly Leu Gly Glu Leu Arg Ser 
1               5                   10                  15      


Trp Trp Glu Val Pro Ala Ile Ala His Phe Cys Ser Leu Phe Arg Thr 
            20                  25                  30          


Ala Phe Arg Leu Pro Asp Phe Glu Ile Glu Glu Leu Glu Ala Ala Leu 
        35                  40                  45              


His Arg Asp Asp Val Glu Phe Ile Ser Asp Leu Ile Ala Cys Leu Leu 
    50                  55                  60                  


Gln Gly Cys Tyr Gln Arg Arg Asp Ile Thr Pro Gln Thr Phe His Ser 
65                  70                  75                  80  


Tyr Leu Glu Asp Ile Ile Asn Tyr Arg Trp Glu Leu Glu Glu Gly Lys 
                85                  90                  95      


Pro Asn Pro Leu Arg Glu Ala Ser Phe Gln Asp Leu Pro Leu Arg Thr 
            100                 105                 110         


Arg Val Glu Ile Leu His Arg Leu Cys Asp Tyr Arg Leu Asp Ala Asp 
        115                 120                 125             


Asp Val Phe Asp Leu Leu Lys Gly Leu Asp Ala Asp Ser Leu Arg Val 
    130                 135                 140                 


Glu Pro Leu Gly Glu Asp Asn Ser Gly Ala Leu Tyr Trp Tyr Phe Tyr 
145                 150                 155                 160 


Gly Thr Arg Met Tyr Lys Glu Asp Pro Val Gln Gly Lys Ser Asn Gly 
                165                 170                 175     


Glu Leu Ser Leu Ser Arg Glu Ser Glu Gly Gln Lys Asn Val Ser Ser 
            180                 185                 190         


Ile Pro Gly Lys Thr Gly Lys Arg Arg Gly Arg Pro Pro Lys Arg Lys 
        195                 200                 205             


Lys Leu Gln Glu Glu Ile Leu Leu Ser Glu Lys Gln Glu Glu Asn Ser 
    210                 215                 220                 


Leu Ala Ser Glu Pro Gln Thr Arg His Gly Ser Gln Gly Pro Gly Gln 
225                 230                 235                 240 


Gly Thr Trp Trp Leu Leu Cys Gln Thr Glu Glu Glu Trp Arg Gln Val 
                245                 250                 255     


Thr Glu Ser Phe Arg Glu Arg Thr Ser Leu Arg Glu Arg Gln Leu Tyr 
            260                 265                 270         


Lys Leu Leu Ser Glu Asp Phe Leu Pro Glu Ile Cys Asn Met Ile Ala 
        275                 280                 285             


Gln Lys Gly Lys Arg Pro Gln Arg Thr Lys Ala Glu Leu His Pro Arg 
    290                 295                 300                 


Trp Met Ser Asp His Leu Ser Ile Lys Pro Val Lys Gln Glu Glu Thr 
305                 310                 315                 320 


Pro Val Leu Thr Arg Ile Glu Lys Gln Lys Arg Lys Glu Glu Glu Glu 
                325                 330                 335     


Glu Arg Gln Ile Leu Leu Ala Val Gln Lys Lys Glu Gln Glu Gln Met 
            340                 345                 350         


Leu Lys Glu Glu Arg Lys Arg Glu Leu Glu Glu Lys Val Lys Ala Val 
        355                 360                 365             


Glu Asp Arg Ala Lys Arg Arg Lys Leu Arg Glu Glu Arg Ala Trp Leu 
    370                 375                 380                 


Leu Ala Gln Gly Lys Glu Leu Pro Pro Glu Leu Ser His Leu Asp Pro 
385                 390                 395                 400 


Asn Ser Pro Met Arg Glu Glu Lys Lys Thr Lys Asp Leu Phe Glu Leu 
                405                 410                 415     


Asp Asp Asp Phe Thr Ala Met Tyr Lys Val Leu Asp Val Val Lys Ala 
            420                 425                 430         


His Lys Asp Ser Trp Pro Phe Leu Glu Pro Val Asp Glu Ser Tyr Ala 
        435                 440                 445             


Pro Asn Tyr Tyr Gln Ile Ile Lys Ala Pro Met Asp Ile Ser Ser Met 
    450                 455                 460                 


Glu Lys Lys Leu Asn Gly Gly Leu Tyr Cys Thr Lys Glu Glu Phe Val 
465                 470                 475                 480 


Asn Asp Met Lys Thr Met Phe Arg Asn Cys Arg Lys Tyr Asn Gly Glu 
                485                 490                 495     


Ser Ser Glu Tyr Thr Lys Met Ser Asp Asn Leu Glu Arg Cys Phe His 
            500                 505                 510         


Arg Ala Met Met Lys His Phe Pro Gly Glu Asp Gly Asp Thr Asp Glu 
        515                 520                 525             


Glu Phe Trp Ile Arg Glu Asp Glu Lys Arg Glu Lys Arg Arg Ser Arg 
    530                 535                 540                 


Ala Gly Arg Ser Gly Gly Ser His Val Trp Thr Arg Ser Arg Asp Pro 
545                 550                 555                 560 


Glu Gly Ser Ser Arg Lys Gln Gln Pro Met Glu Asn Gly Gly Lys Ser 
                565                 570                 575     


Leu Pro Pro Thr Arg Arg Ala Pro Ser Ser Gly Asp Asp Gln Ser Ser 
            580                 585                 590         


Ser Ser Thr Gln Pro Pro Arg Glu Val Gly Thr Ser Asn Gly Arg Gly 
        595                 600                 605             


Phe Ser His Pro Leu His Cys Gly Gly Thr Pro Ser Gln Ala Pro Phe 
    610                 615                 620                 


Leu Asn Gln Met Arg Pro Ala Val Pro Gly Thr Phe Gly Pro Leu Arg 
625                 630                 635                 640 


Gly Ser Asp Pro Ala Thr Leu Tyr Gly Ser Ser Gly Val Pro Glu Pro 
                645                 650                 655     


His Pro Gly Glu Pro Val Gln Gln Arg Gln Pro Phe Thr Met Gln Pro 
            660                 665                 670         


Pro Val Gly Ile Asn Ser Leu Arg Gly Pro Arg Leu Gly Thr Pro Glu 
        675                 680                 685             


Glu Lys Gln Met Cys Gly Gly Leu Thr His Leu Ser Asn Met Gly Pro 
    690                 695                 700                 


His Pro Gly Ser Leu Gln Leu Gly Gln Ile Ser Gly Pro Ser Gln Asp 
705                 710                 715                 720 


Gly Ser Met Tyr Ala Pro Ala Gln Phe Gln Pro Gly Phe Ile Pro Pro 
                725                 730                 735     


Arg His Gly Gly Ala Pro Ala Arg Pro Pro Asp Phe Pro Glu Ser Ser 
            740                 745                 750         


Glu Ile Pro Pro Ser His Met Tyr Arg Ser Tyr Lys Tyr Leu Asn Arg 
        755                 760                 765             


Val His Ser Ala Val Trp Asn Gly Asn His Gly Ala Thr Asn Gln Gly 
    770                 775                 780                 


Pro Leu Gly Pro Asp Glu Lys Pro His Leu Gly Pro Gly Pro Ser His 
785                 790                 795                 800 


Gln Pro Arg Thr Leu Gly His Val Met Asp Ser Arg Val Met Arg Pro 
                805                 810                 815     


Pro Val Pro Pro Asn Gln Trp Thr Glu Gln Ser Gly Phe Leu Pro His 
            820                 825                 830         


Gly Val Pro Ser Ser Gly Tyr Met Arg Pro Pro Cys Lys Ser Ala Gly 
        835                 840                 845             


His Arg Leu Gln Pro Pro Pro Val Pro Ala Pro Ser Ser Leu Phe Gly 
    850                 855                 860                 


Ala Pro Ala Gln Ala Leu Arg Gly Val Gln Gly Gly Asp Ser Met Met 
865                 870                 875                 880 


Asp Ser Pro Glu Met Ile Ala Met Gln Gln Leu Ser Ser Arg Val Cys 
                885                 890                 895     


Pro Pro Gly Val Pro Tyr His Pro His Gln Pro Ala His Pro Arg Leu 
            900                 905                 910         


Pro Gly Pro Phe Pro Gln Val Ala His Pro Met Ser Val Thr Val Ser 
        915                 920                 925             


Ala Pro Lys Pro Ala Leu Gly Asn Pro Gly Arg Ala Pro Glu Asn Ser 
    930                 935                 940                 


Glu Ala Gln Glu Pro Glu Asn Asp Gln Ala Glu Pro Leu Pro Gly Leu 
945                 950                 955                 960 


Glu Glu Lys Pro Pro Gly Val Gly Thr Ser Glu Gly Val Tyr Leu Thr 
                965                 970                 975     


Gln Leu Pro His Pro Thr Pro Pro Leu Gln Thr Asp Cys Thr Arg Gln 
            980                 985                 990         


Ser Ser Pro Gln Glu Arg Glu Thr  Val Gly Pro Glu Leu  Lys Ser Ser 
        995                 1000                 1005             


Ser Ser  Glu Ser Ala Asp Asn  Cys Lys Ala Met Lys  Gly Lys Asn 
    1010                 1015                 1020             


Pro Trp  Pro Ser Asp Ser Ser  Tyr Pro Gly Pro Ala  Ala Gln Gly 
    1025                 1030                 1035             


Cys Val  Arg Asp Leu Ser Thr  Val Ala Asp Arg Gly  Ala Leu Ser 
    1040                 1045                 1050             


Glu Asn  Gly Val Ile Gly Glu  Ala Ser Pro Cys Gly  Ser Glu Gly 
    1055                 1060                 1065             


Lys Gly  Leu Gly Ser Ser Gly  Ser Glu Lys Leu Leu  Cys Pro Arg 
    1070                 1075                 1080             


Gly Arg  Thr Leu Gln Glu Thr  Met Pro Cys Thr Gly  Gln Asn Ala 
    1085                 1090                 1095             


Ala Thr  Pro Pro Ser Thr Asp  Pro Gly Leu Thr Gly  Gly Thr Val 
    1100                 1105                 1110             


Ser Gln  Phe Pro Pro Leu Tyr  Met Pro Gly Leu Glu  Tyr Pro Asn 
    1115                 1120                 1125             


Ser Ala  Ala His Tyr His Ile  Ser Pro Gly Leu Gln  Gly Val Gly 
    1130                 1135                 1140             


Pro Val  Met Gly Gly Lys Ser  Pro Ala Ser His Pro  Gln His Phe 
    1145                 1150                 1155             


Pro Pro  Arg Gly Phe Gln Ser  Asn His Pro His Ser  Gly Gly Phe 
    1160                 1165                 1170             


Pro Arg  Tyr Arg Pro Pro Gln  Gly Met Arg Tyr Ser  Tyr His Pro 
    1175                 1180                 1185             


Pro Pro  Gln Pro Ser Tyr His  His Tyr Gln Arg Thr  Pro Tyr Tyr 
    1190                 1195                 1200             


Ala Cys  Pro Gln Ser Phe Ser  Asp Trp Gln Arg Pro  Leu His Pro 
    1205                 1210                 1215             


Gln Gly  Ser Pro Ser Gly Pro  Pro Ala Ser Gln Pro  Pro Pro Pro 
    1220                 1225                 1230             


Arg Ser  Leu Phe Ser Asp Lys  Asn Ala Met Ala Ser  Leu Gln Gly 
    1235                 1240                 1245             


Cys Glu  Thr Leu Asn Ala Ala  Leu Thr Ser Pro Thr  Arg Met Asp 
    1250                 1255                 1260             


Ala Val  Ala Ala Lys Val Pro  Asn Asp Gly Gln Asn  Pro Gly Pro 
    1265                 1270                 1275             


Glu Glu  Glu Lys Leu Asp Glu  Ser Met Glu Arg Pro  Glu Ser Pro 
    1280                 1285                 1290             


Lys Glu  Phe Leu Asp Leu Asp  Asn His Asn Ala Ala  Thr Lys Arg 
    1295                 1300                 1305             


Gln Ser  Ser Leu Ser Ala Ser  Glu Tyr Leu Tyr Gly  Thr Pro Pro 
    1310                 1315                 1320             


Pro Leu  Ser Ser Gly Met Gly  Phe Gly Ser Ser Ala  Phe Pro Pro 
    1325                 1330                 1335             


His Ser  Val Met Leu Gln Thr  Gly Pro Pro Tyr Thr  Pro Gln Arg 
    1340                 1345                 1350             


Pro Ala  Ser His Phe Gln Pro  Arg Ala Tyr Ser Ser  Pro Val Ala 
    1355                 1360                 1365             


Ala Leu  Pro Pro His His Pro  Gly Ala Thr Gln Pro  Asn Gly Leu 
    1370                 1375                 1380             


Ser Gln  Glu Gly Pro Ile Tyr  Arg Cys Gln Glu Glu  Gly Leu Gly 
    1385                 1390                 1395             


His Phe  Gln Ala Val Met Met  Glu Gln Ile Gly Thr  Arg Ser Gly 
    1400                 1405                 1410             


Ile Arg  Gly Pro Phe Gln Glu  Met Tyr Arg Pro Ser  Gly Met Gln 
    1415                 1420                 1425             


Met His  Pro Val Gln Ser Gln  Ala Ser Phe Pro Lys  Thr Pro Thr 
    1430                 1435                 1440             


Ala Ala  Thr Ser Gln Glu Glu  Val Pro Pro His Lys  Pro Pro Thr 
    1445                 1450                 1455             


Leu Pro  Leu Asp Gln Ser 
    1460                 


<210>  1998
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELA1__Homo_sapiens__NP_001962

<400>  1998

Met Leu Val Leu Tyr Gly His Ser Thr Gln Asp Leu Pro Glu Thr Asn 
1               5                   10                  15      


Ala Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser 
            20                  25                  30          


Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys 
        35                  40                  45              


Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys 
    50                  55                  60                  


Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu 
65                  70                  75                  80  


Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val 
                85                  90                  95      


Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile 
            100                 105                 110         


Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln 
        115                 120                 125             


Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro 
    130                 135                 140                 


Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala 
145                 150                 155                 160 


Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 
                165                 170                 175     


Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys 
            180                 185                 190         


Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly 
        195                 200                 205             


Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr 
    210                 215                 220                 


Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val 
225                 230                 235                 240 


Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala 
                245                 250                 255     


Ser Asn 
        


<210>  1999
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELA3B__Homo_sapiens__XP_011539434

<400>  1999

Met Met Leu Arg Leu Leu Ser Ser Leu Leu Leu Val Ala Val Ala Ser 
1               5                   10                  15      


Gly Tyr Gly Pro Pro Ser Ser Arg Pro Ser Ser Arg Val Val Asn Gly 
            20                  25                  30          


Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr 
        35                  40                  45              


Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly Ser Leu Ile Ala 
    50                  55                  60                  


Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser Ser Ser Arg Thr 
65                  70                  75                  80  


Tyr Gln Val Val Leu Gly Glu Tyr Asp Arg Ala Val Lys Glu Gly Pro 
                85                  90                  95      


Glu Gln Val Ile Pro Ile Asn Ser Gly Asp Leu Phe Val His Pro Leu 
            100                 105                 110         


Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile Ala Leu Ile Lys 
        115                 120                 125             


Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln Leu Ala Ser Leu 
    130                 135                 140                 


Pro Pro Ala Gly Asp Ile Leu Pro Asn Glu Thr Pro Cys Tyr Ile Thr 
145                 150                 155                 160 


Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro Asp Lys Leu Gln 
                165                 170                 175     


Glu Ala Leu Leu Pro Val Val Asp Tyr Glu His Cys Ser Arg Trp Asn 
            180                 185                 190         


Trp Trp Gly Ser Ser Val Lys Lys Thr Met Val Cys Ala Gly Gly Asp 
        195                 200                 205             


Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Pro 
    210                 215                 220                 


Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr Ser Phe Val Ser 
225                 230                 235                 240 


Ala Phe Gly Cys Asn Thr Arg Arg Lys Pro Thr Val Phe Thr Arg Val 
                245                 250                 255     


Ser Ala Phe Ile Asp Trp Ile Glu Glu Gly Leu Cys Arg Met Glu Thr 
            260                 265                 270         


Thr Leu Ala Cys Leu Pro Gly Ser Gln Lys Leu Gln Gly Asn Lys Ala 
        275                 280                 285             


Pro Glu Ser Arg Thr 
    290             


<210>  2000
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELF1__Homo_sapiens__NP_001166110

<400>  2000

Met Ala Ala Phe Lys Leu Asp Phe Leu Pro Glu Met Met Val Asp His 
1               5                   10                  15      


Cys Ser Leu Asn Ser Ser Pro Val Ser Lys Lys Met Asn Gly Thr Leu 
            20                  25                  30          


Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile Lys Met Phe Val Gly 
        35                  40                  45              


Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu Arg Glu Leu Phe Glu 
    50                  55                  60                  


Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu Arg Asp Arg Ser Gln 
65                  70                  75                  80  


Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val Thr Phe Tyr Thr Arg 
                85                  90                  95      


Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His Asn Met Lys Val Leu 
            100                 105                 110         


Pro Gly Met His His Pro Ile Gln Met Lys Pro Ala Asp Ser Glu Lys 
        115                 120                 125             


Asn Asn Val Glu Asp Arg Lys Leu Phe Ile Gly Met Ile Ser Lys Lys 
    130                 135                 140                 


Cys Thr Glu Asn Asp Ile Arg Val Met Phe Ser Ser Phe Gly Gln Ile 
145                 150                 155                 160 


Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp Gly Leu Ser Arg Gly Cys 
                165                 170                 175     


Ala Phe Val Thr Phe Thr Thr Arg Ala Met Ala Gln Thr Ala Ile Lys 
            180                 185                 190         


Ala Met His Gln Ala Gln Thr Met Glu Gly Cys Ser Ser Pro Met Val 
        195                 200                 205             


Val Lys Phe Ala Asp Thr Gln Lys Asp Lys Glu Gln Lys Arg Met Ala 
    210                 215                 220                 


Gln Gln Leu Gln Gln Gln Met Gln Gln Ile Ser Ala Ala Ser Val Trp 
225                 230                 235                 240 


Gly Asn Leu Ala Gly Leu Asn Thr Leu Gly Pro Gln Tyr Leu Ala Leu 
                245                 250                 255     


Tyr Leu Gln Leu Leu Gln Gln Thr Ala Ser Ser Gly Asn Leu Asn Thr 
            260                 265                 270         


Leu Ser Ser Leu His Pro Met Gly Gly Leu Asn Ala Met Gln Leu Gln 
        275                 280                 285             


Asn Leu Ala Ala Leu Ala Ala Ala Ala Ser Ala Ala Gln Asn Thr Pro 
    290                 295                 300                 


Ser Gly Thr Asn Ala Leu Thr Thr Ser Ser Ser Pro Leu Ser Val Leu 
305                 310                 315                 320 


Thr Ser Ser Gly Ser Ser Pro Ser Ser Ser Ser Ser Asn Ser Val Asn 
                325                 330                 335     


Pro Ile Ala Ser Leu Gly Ala Leu Gln Thr Leu Ala Gly Ala Thr Ala 
            340                 345                 350         


Gly Leu Asn Val Gly Ser Leu Ala Gly Met Ala Ala Leu Asn Gly Gly 
        355                 360                 365             


Leu Gly Ser Ser Gly Leu Ser Asn Gly Thr Gly Ser Thr Met Glu Ala 
    370                 375                 380                 


Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu 
385                 390                 395                 400 


Pro Thr Leu Tyr Asn Gln Asn Leu Leu Thr Gln Gln Ser Ile Gly Ala 
                405                 410                 415     


Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr 
            420                 425                 430         


His Leu Pro Gln Glu Phe Gly Asp Gln Asp Leu Leu Gln Met Phe Met 
        435                 440                 445             


Pro Phe Gly Asn Val Val Ser Ala Lys Val Phe Ile Asp Lys Gln Thr 
    450                 455                 460                 


Asn Leu Ser Lys Cys Phe Gly Phe Val Ser Tyr Asp Asn Pro Val Ser 
465                 470                 475                 480 


Ala Gln Ala Ala Ile Gln Ser Met Asn Gly Phe Gln Ile Gly Met Lys 
                485                 490                 495     


Arg Leu Lys Val Gln Leu Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
            500                 505                 510         


<210>  2001
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELF2__Homo_sapiens__NP_001020247

<400>  2001

Met Asn Gly Ala Leu Asp His Ser Asp Gln Pro Asp Pro Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Ile Pro Arg Ser Trp Ser Glu Lys Glu Leu 
            20                  25                  30          


Lys Glu Leu Phe Glu Pro Tyr Gly Ala Val Tyr Gln Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Ile Lys Thr Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Ser Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Val Ser Lys Lys Cys Asn Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Pro Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Ser Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Asn Ala Ile Lys Ala Met His Gln Ser Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Ile Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Arg Arg Leu Gln Gln Gln Leu Ala Gln Gln Met Gln Gln Leu 
        195                 200                 205             


Asn Thr Ala Thr Trp Gly Asn Leu Thr Gly Leu Gly Gly Leu Thr Pro 
    210                 215                 220                 


Gln Tyr Leu Ala Leu Leu Gln Gln Ala Thr Ser Ser Ser Asn Leu Gly 
225                 230                 235                 240 


Ala Phe Ser Gly Ile Gln Gln Met Ala Gly Met Asn Ala Leu Gln Leu 
                245                 250                 255     


Gln Asn Leu Ala Thr Leu Ala Ala Ala Ala Ala Ala Ala Gln Thr Ser 
            260                 265                 270         


Ala Thr Ser Thr Asn Ala Asn Pro Leu Ser Thr Thr Ser Ser Ala Leu 
        275                 280                 285             


Gly Ala Leu Thr Ser Pro Val Ala Ala Ser Thr Pro Asn Ser Thr Ala 
    290                 295                 300                 


Gly Ala Ala Met Asn Ser Leu Thr Ser Leu Gly Thr Leu Gln Gly Leu 
305                 310                 315                 320 


Ala Gly Ala Thr Val Gly Leu Asn Asn Ile Asn Ala Leu Ala Val Ala 
                325                 330                 335     


Gln Met Leu Ser Gly Met Ala Ala Leu Asn Gly Gly Leu Gly Ala Thr 
            340                 345                 350         


Gly Leu Thr Asn Gly Thr Ala Gly Thr Met Asp Ala Leu Thr Gln Ala 
        355                 360                 365             


Tyr Ser Gly Ile Gln Gln Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr 
    370                 375                 380                 


Ser Gln Ser Leu Leu Gln Gln Gln Ser Ala Ala Gly Ser Gln Lys Glu 
385                 390                 395                 400 


Gly Pro Glu Gly Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe 
                405                 410                 415     


Gly Asp Gln Asp Ile Leu Gln Met Phe Met Pro Phe Gly Asn Val Ile 
            420                 425                 430         


Ser Ala Lys Val Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe 
        435                 440                 445             


Gly Phe Val Ser Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln 
    450                 455                 460                 


Ala Met Asn Gly Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu 
465                 470                 475                 480 


Lys Arg Ser Lys Asn Asp Ser Lys Pro Tyr 
                485                 490 


<210>  2002
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELF4__Homo_sapiens__NP_001020258

<400>  2002

Met Tyr Ile Lys Met Ala Thr Leu Ala Asn Gly Gln Ala Asp Asn Ala 
1               5                   10                  15      


Ser Leu Ser Thr Asn Gly Leu Gly Ser Ser Pro Gly Ser Ala Gly His 
            20                  25                  30          


Met Asn Gly Leu Ser His Ser Pro Gly Asn Pro Ser Thr Ile Pro Met 
        35                  40                  45              


Lys Asp His Asp Ala Ile Lys Leu Phe Ile Gly Gln Ile Pro Arg Asn 
    50                  55                  60                  


Leu Asp Glu Lys Asp Leu Lys Pro Leu Phe Glu Glu Phe Gly Lys Ile 
65                  70                  75                  80  


Tyr Glu Leu Thr Val Leu Lys Asp Arg Phe Thr Gly Met His Lys Gly 
                85                  90                  95      


Cys Ala Phe Leu Thr Tyr Cys Glu Arg Glu Ser Ala Leu Lys Ala Gln 
            100                 105                 110         


Ser Ala Leu His Glu Gln Lys Thr Leu Pro Gly Met Asn Arg Pro Ile 
        115                 120                 125             


Gln Val Lys Pro Ala Asp Ser Glu Ser Arg Gly Gly Ser Ser Cys Leu 
    130                 135                 140                 


Arg Gln Pro Pro Ser Gln Asp Arg Lys Leu Phe Val Gly Met Leu Asn 
145                 150                 155                 160 


Lys Gln Gln Ser Glu Asp Asp Val Arg Arg Leu Phe Glu Ala Phe Gly 
                165                 170                 175     


Asn Ile Glu Glu Cys Thr Ile Leu Arg Gly Pro Asp Gly Asn Ser Lys 
            180                 185                 190         


Gly Cys Ala Phe Val Lys Tyr Ser Ser His Ala Glu Ala Gln Ala Ala 
        195                 200                 205             


Ile Asn Ala Leu His Gly Ser Gln Thr Met Pro Gly Ala Ser Ser Ser 
    210                 215                 220                 


Leu Val Val Lys Phe Ala Asp Thr Asp Lys Glu Arg Thr Met Arg Arg 
225                 230                 235                 240 


Met Gln Gln Met Ala Gly Gln Met Gly Met Phe Asn Pro Met Ala Ile 
                245                 250                 255     


Pro Phe Gly Ala Tyr Gly Ala Tyr Ala Gln Ala Met Gln Gln Gln Ala 
            260                 265                 270         


Ala Leu Met Ala Ser Val Ala Gln Gly Gly Tyr Leu Asn Pro Met Ala 
        275                 280                 285             


Ala Phe Ala Ala Ala Gln Met Gln Gln Met Ala Ala Leu Asn Met Asn 
    290                 295                 300                 


Gly Leu Ala Ala Ala Pro Met Thr Pro Thr Ser Gly Gly Ser Thr Pro 
305                 310                 315                 320 


Pro Gly Ile Thr Ala Pro Ala Val Pro Ser Ile Pro Ser Pro Ile Gly 
                325                 330                 335     


Val Asn Gly Phe Thr Gly Leu Pro Pro Gln Ala Asn Gly Gln Pro Ala 
            340                 345                 350         


Ala Glu Ala Val Phe Ala Asn Gly Ile His Pro Tyr Pro Ala Gln Ser 
        355                 360                 365             


Pro Thr Ala Ala Asp Pro Leu Gln Gln Ala Tyr Ala Gly Val Gln Gln 
    370                 375                 380                 


Tyr Ala Gly Pro Ala Ala Tyr Pro Ala Ala Tyr Gly Gln Ile Ser Gln 
385                 390                 395                 400 


Ala Phe Pro Gln Pro Pro Pro Met Ile Pro Gln Gln Gln Arg Glu Gly 
                405                 410                 415     


Pro Glu Gly Cys Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly 
            420                 425                 430         


Asp Ala Glu Leu Met Gln Met Phe Leu Pro Phe Gly Phe Val Ser Phe 
        435                 440                 445             


Asp Asn Pro Ala Ser Ala Gln Thr Ala Ile Gln Ala Met Asn Gly Phe 
    450                 455                 460                 


Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Pro Lys Asp 
465                 470                 475                 480 


Ala Asn Arg Pro Tyr 
                485 


<210>  2003
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELF5__Homo_sapiens__NP_001166144

<400>  2003

Met Ala Arg Leu Thr Glu Ser Glu Ala Arg Arg Gln Gln Gln Gln Leu 
1               5                   10                  15      


Leu Gln Pro Arg Pro Ser Pro Val Gly Ser Ser Gly Pro Glu Pro Pro 
            20                  25                  30          


Gly Gly Gln Pro Asp Gly Met Lys Asp Leu Asp Ala Ile Lys Leu Phe 
        35                  40                  45              


Val Gly Gln Ile Pro Arg His Leu Asp Glu Lys Asp Leu Lys Pro Leu 
    50                  55                  60                  


Phe Glu Gln Phe Gly Arg Ile Tyr Glu Leu Thr Val Leu Lys Asp Pro 
65                  70                  75                  80  


Tyr Thr Gly Met His Lys Gly Cys Ala Phe Leu Thr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Ser Ala Ile Lys Ala Gln Thr Ala Leu His Glu Gln Lys Thr Leu 
            100                 105                 110         


Pro Gly Met Ala Arg Pro Ile Gln Val Lys Pro Ala Asp Ser Glu Ser 
        115                 120                 125             


Arg Gly Gly Arg Asp Arg Lys Leu Phe Val Gly Met Leu Asn Lys Gln 
    130                 135                 140                 


Gln Ser Glu Glu Asp Val Leu Arg Leu Phe Gln Pro Phe Gly Val Ile 
145                 150                 155                 160 


Asp Glu Cys Thr Val Leu Arg Gly Pro Asp Gly Ser Ser Lys Gly Cys 
                165                 170                 175     


Ala Phe Val Lys Phe Ser Ser His Thr Glu Ala Gln Ala Ala Ile His 
            180                 185                 190         


Ala Leu His Gly Ser Gln Thr Met Pro Gly Ala Ser Ser Ser Leu Val 
        195                 200                 205             


Val Lys Phe Ala Asp Thr Asp Lys Glu Arg Thr Leu Arg Arg Met Gln 
    210                 215                 220                 


Gln Met Val Gly Gln Leu Gly Ile Leu Thr Pro Ser Leu Thr Leu Pro 
225                 230                 235                 240 


Phe Ser Pro Tyr Ser Ala Tyr Ala Gln Ala Leu Met Gln Gln Gln Thr 
                245                 250                 255     


Thr Val Leu Ser Thr Ser Gly Ser Tyr Leu Ser Pro Gly Val Ala Phe 
            260                 265                 270         


Ser Pro Cys His Ile Gln Gln Ile Gly Ala Val Ser Leu Asn Gly Leu 
        275                 280                 285             


Pro Ala Thr Pro Ile Ala Pro Ala Ser Gly Val Val Pro Phe Pro Gly 
    290                 295                 300                 


Gly His Pro Ala Leu Glu Thr Val Tyr Ala Asn Gly Leu Val Pro Tyr 
305                 310                 315                 320 


Pro Ala Gln Ser Pro Thr Val Ala Glu Thr Leu His Pro Ala Phe Ser 
                325                 330                 335     


Gly Val Gln Gln Tyr Thr Ala Met Tyr Pro Thr Ala Ala Ile Thr Pro 
            340                 345                 350         


Ile Ala His Ser Val Pro Gln Pro Pro Pro Leu Leu Gln Gln Gln Gln 
        355                 360                 365             


Arg Glu Gly Val Trp Arg His Gly Ala Asp Ala Asp Val Pro Thr Leu 
    370                 375                 380                 


Arg Gln Tyr His Phe Leu Gln Gly Val Tyr Gly Ser Ser Tyr Gln Pro 
385                 390                 395                 400 


Glu Gln Val Phe Arg Leu Arg Glu Leu 
                405                 


<210>  2004
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELF6__Homo_sapiens__NP_001166155

<400>  2004

Met Ala Ala Ala Pro Gly Gly Ser Ala Gln Pro Ala Gly Pro Gly Pro 
1               5                   10                  15      


Arg Leu Gly Phe Ser Thr Ala Asp Ser Gly Val Gly Met Ser Gly Leu 
            20                  25                  30          


Asn Pro Gly Pro Ala Val Pro Met Lys Asp His Asp Ala Ile Lys Leu 
        35                  40                  45              


Phe Val Gly Gln Ile Pro Arg Gly Leu Asp Glu Gln Asp Leu Lys Pro 
    50                  55                  60                  


Leu Phe Glu Glu Phe Gly Arg Ile Tyr Glu Leu Thr Val Leu Lys Asp 
65                  70                  75                  80  


Arg Leu Thr Gly Leu His Lys Gly Cys Ala Phe Leu Thr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Ala Leu Lys Ala Gln Ser Ala Leu His Glu Gln Lys Thr 
            100                 105                 110         


Leu Pro Gly Met Asn Arg Pro Ile Gln Val Lys Pro Ala Ala Ser Glu 
        115                 120                 125             


Gly Arg Gly Glu Asp Arg Lys Leu Phe Val Gly Met Leu Gly Lys Gln 
    130                 135                 140                 


Gln Gly Glu Glu Asp Val Arg Arg Leu Phe Gln Pro Phe Gly His Ile 
145                 150                 155                 160 


Glu Glu Cys Thr Val Leu Arg Ser Pro Asp Gly Thr Ser Lys Gly Cys 
                165                 170                 175     


Ala Phe Val Lys Phe Gly Ser Gln Gly Glu Ala Gln Ala Ala Ile Arg 
            180                 185                 190         


Gly Leu His Gly Ser Arg Thr Met Ala Gly Ala Ser Ser Ser Leu Val 
        195                 200                 205             


Val Lys Leu Ala Asp Thr Asp Arg Glu Arg Ala Leu Arg Arg Met Gln 
    210                 215                 220                 


Gln Met Ala Gly His Leu Gly Ala Phe His Pro Ala Pro Leu Pro Leu 
225                 230                 235                 240 


Gly Ala Cys Gly Ala Tyr Thr Thr Ala Ile Leu Gln His Gln Ala Ala 
                245                 250                 255     


Leu Leu Ala Ala Ala Gln Gly Pro Gly Leu Gly Pro Val Ala Ala Val 
            260                 265                 270         


Ala Ala Gln Met Gln His Val Ala Ala Phe Ser Leu Val Ala Ala Pro 
        275                 280                 285             


Leu Leu Pro Ala Ala Ala Ala Asn Ser Pro Pro Gly Ser Gly Pro Gly 
    290                 295                 300                 


Thr Leu Pro Gly Leu Pro Ala Pro Ile Gly Val Asn Gly Phe Gly Pro 
305                 310                 315                 320 


Leu Thr Pro Gln Thr Asn Gly Gln Pro Gly Ser Asp Thr Leu Tyr Asn 
                325                 330                 335     


Asn Gly Leu Ser Pro Tyr Pro Ala Gln Ser Pro Gly Val Ala Asp Pro 
            340                 345                 350         


Leu Gln Gln Ala Tyr Ala Gly Met His His Tyr Ala Gly Pro Glu Gly 
        355                 360                 365             


Cys Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Ala Glu 
    370                 375                 380                 


Leu Ile Gln Thr Phe Leu Pro Phe Gly Ala Val Val Ser Ala Lys Val 
385                 390                 395                 400 


Phe Val Asp Arg Ala Thr Asn Gln Ser Lys Cys Phe Gly Phe Val Ser 
                405                 410                 415     


Phe Asp Asn Pro Thr Ser Ala Gln Thr Ala Ile Gln Ala Met Asn Gly 
            420                 425                 430         


Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Pro Lys 
        435                 440                 445             


Asp Ala Asn Arg Pro Tyr 
    450                 


<210>  2005
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEL__Homo_sapiens__NP_001798

<400>  2005

Met Leu Thr Met Gly Arg Leu Gln Leu Val Val Leu Gly Leu Thr Cys 
1               5                   10                  15      


Cys Trp Ala Val Ala Ser Ala Ala Lys Leu Gly Ala Val Tyr Thr Glu 
            20                  25                  30          


Gly Gly Phe Val Glu Gly Val Asn Lys Lys Leu Gly Leu Leu Gly Asp 
        35                  40                  45              


Ser Val Asp Ile Phe Lys Gly Ile Pro Phe Ala Ala Pro Thr Lys Ala 
    50                  55                  60                  


Leu Glu Asn Pro Gln Pro His Pro Gly Trp Gln Gly Thr Leu Lys Ala 
65                  70                  75                  80  


Lys Asn Phe Lys Lys Arg Cys Leu Gln Ala Thr Ile Thr Gln Asp Ser 
                85                  90                  95      


Thr Tyr Gly Asp Glu Asp Cys Leu Tyr Leu Asn Ile Trp Val Pro Gln 
            100                 105                 110         


Gly Arg Lys Gln Val Ser Arg Asp Leu Pro Val Met Ile Trp Ile Tyr 
        115                 120                 125             


Gly Gly Ala Phe Leu Met Gly Ser Gly His Gly Ala Asn Phe Leu Asn 
    130                 135                 140                 


Asn Tyr Leu Tyr Asp Gly Glu Glu Ile Ala Thr Arg Gly Asn Val Ile 
145                 150                 155                 160 


Val Val Thr Phe Asn Tyr Arg Val Gly Pro Leu Gly Phe Leu Ser Thr 
                165                 170                 175     


Gly Asp Ala Asn Leu Pro Gly Asn Tyr Gly Leu Arg Asp Gln His Met 
            180                 185                 190         


Ala Ile Ala Trp Val Lys Arg Asn Ile Ala Ala Phe Gly Gly Asp Pro 
        195                 200                 205             


Asn Asn Ile Thr Leu Phe Gly Glu Ser Ala Gly Gly Ala Ser Val Ser 
    210                 215                 220                 


Leu Gln Thr Leu Ser Pro Tyr Asn Lys Gly Leu Ile Arg Arg Ala Ile 
225                 230                 235                 240 


Ser Gln Ser Gly Val Ala Leu Ser Pro Trp Val Ile Gln Lys Asn Pro 
                245                 250                 255     


Leu Phe Trp Ala Lys Lys Val Ala Glu Lys Val Gly Cys Pro Val Gly 
            260                 265                 270         


Asp Ala Ala Arg Met Ala Gln Cys Leu Lys Val Thr Asp Pro Arg Ala 
        275                 280                 285             


Leu Thr Leu Ala Tyr Lys Val Pro Leu Ala Gly Leu Glu Tyr Pro Met 
    290                 295                 300                 


Leu His Tyr Val Gly Phe Val Pro Val Ile Asp Gly Asp Phe Ile Pro 
305                 310                 315                 320 


Ala Asp Pro Ile Asn Leu Tyr Ala Asn Ala Ala Asp Ile Asp Tyr Ile 
                325                 330                 335     


Ala Gly Thr Asn Asn Met Asp Gly His Ile Phe Ala Ser Ile Asp Met 
            340                 345                 350         


Pro Ala Ile Asn Lys Gly Asn Lys Lys Val Thr Glu Glu Asp Phe Tyr 
        355                 360                 365             


Lys Leu Val Ser Glu Phe Thr Ile Thr Lys Gly Leu Arg Gly Ala Lys 
    370                 375                 380                 


Thr Thr Phe Asp Val Tyr Thr Glu Ser Trp Ala Gln Asp Pro Ser Gln 
385                 390                 395                 400 


Glu Asn Lys Lys Lys Thr Val Val Asp Phe Glu Thr Asp Val Leu Phe 
                405                 410                 415     


Leu Val Pro Thr Glu Ile Ala Leu Ala Gln His Arg Ala Asn Ala Lys 
            420                 425                 430         


Ser Ala Lys Thr Tyr Ala Tyr Leu Phe Ser His Pro Ser Arg Met Pro 
        435                 440                 445             


Val Tyr Pro Lys Trp Val Gly Ala Asp His Ala Asp Asp Ile Gln Tyr 
    450                 455                 460                 


Val Phe Gly Lys Pro Phe Ala Thr Pro Thr Gly Tyr Arg Pro Gln Asp 
465                 470                 475                 480 


Arg Thr Val Ser Lys Ala Met Ile Ala Tyr Trp Thr Asn Phe Ala Lys 
                485                 490                 495     


Thr Gly Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu 
            500                 505                 510         


Pro Tyr Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met 
        515                 520                 525             


Gly Ser Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr 
    530                 535                 540                 


Trp Thr Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala 
545                 550                 555                 560 


Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro 
                565                 570                 575     


Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly 
            580                 585                 590         


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
        595                 600                 605             


Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser 
    610                 615                 620                 


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
625                 630                 635                 640 


Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp 
                645                 650                 655     


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro 
            660                 665                 670         


Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly 
        675                 680                 685             


Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro 
    690                 695                 700                 


Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr 
705                 710                 715                 720 


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala 
                725                 730                 735     


Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln Met Pro Ala 
            740                 745                 750         


Val Ile Arg Phe 
        755     


<210>  2006
<211>  3014
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELSR1__Homo_sapiens__NP_055061

<400>  2006

Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Thr 
    1430                 1435                 1440             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Thr  Ile Ser Leu Thr Phe  Ala Thr Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Thr Thr  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Thr Gln  Thr Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Thr Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Thr Ser Gly Gly  Pro Thr Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Thr  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Thr  Met Thr Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Thr Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Thr Pro  Thr Asn Val Ala Thr  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Thr Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Thr Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Thr Cys  Asp Met Ala Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Thr Thr  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Thr  Thr Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Thr Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Thr Gln His Thr  Gly Thr Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Thr Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Thr Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Thr Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Thr Gly  Ala Arg Val Pro Arg  Phe Asp Thr 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Thr Thr Pro Gln Thr  Thr Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Thr Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Thr Pro 
    2360                 2365                 2370             


Met Val  Ser Thr Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Thr Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Thr Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Thr His  Val Ala Cys Gln Cys  Ser His Thr 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Thr Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Thr  Phe Ala Trp Thr Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Thr Val 
    2615                 2620                 2625             


Thr Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Thr Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2720                 2725                 2730             


Leu Thr  Arg Ser Leu Asn Cys  Asn Thr Thr Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Thr Asp Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Thr Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Thr Tyr  Pro Pro Pro Leu Thr  Leu Thr Glu 
    2930                 2935                 2940             


Gln Thr  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Thr Ser Ser Arg  Thr Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Thr Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Thr Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210>  2007
<211>  3312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CELSR3__Homo_sapiens__NP_001398

<400>  2007

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  2008
<211>  1361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEMIP__Homo_sapiens__NP_001280227

<400>  2008

Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     


<210>  2009
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEMP1__Homo_sapiens__NP_001041677

<400>  2009

Met Gly Thr Ser Ser Thr Asp Ser Gln Gln Ala Gly His Arg Arg Cys 
1               5                   10                  15      


Ser Thr Ser Asn Thr Ser Ala Glu Asn Leu Thr Cys Leu Ser Leu Pro 
            20                  25                  30          


Gly Ser Pro Gly Lys Thr Ala Pro Leu Pro Gly Pro Ala Gln Ala Gly 
        35                  40                  45              


Ala Gly Gln Pro Leu Pro Lys Gly Cys Ala Ala Val Lys Ala Glu Val 
    50                  55                  60                  


Gly Ile Pro Ala Pro His Thr Ser Gln Glu Val Arg Ile His Ile Arg 
65                  70                  75                  80  


Arg Leu Leu Ser Trp Ala Ala Pro Gly Ala Cys Gly Leu Arg Ser Thr 
                85                  90                  95      


Pro Cys Ala Leu Pro Gln Ala Leu Pro Gln Ala Arg Pro Cys Pro Gly 
            100                 105                 110         


Arg Trp Phe Phe Pro Gly Cys Ser Leu Pro Thr Gly Gly Ala Gln Thr 
        115                 120                 125             


Ile Leu Ser Leu Trp Thr Trp Arg His Phe Leu Asn Trp Ala Leu Gln 
    130                 135                 140                 


Gln Arg Glu Glu Asn Ser Gly Arg Ala Arg Arg Val Pro Pro Val Pro 
145                 150                 155                 160 


Arg Thr Ala Pro Val Ser Lys Gly Glu Gly Ser His Pro Pro Gln Asn 
                165                 170                 175     


Ser Asn Gly Glu Lys Val Lys Thr Ile Thr Pro Asp Val Gly Leu His 
            180                 185                 190         


Gln Ser Leu Thr Ser Asp Pro Thr Val Ala Val Leu Arg Ala Lys Arg 
        195                 200                 205             


Ala Pro Glu Ala His Pro Pro Arg Ser Cys Ser Gly Ser Leu Thr Ala 
    210                 215                 220                 


Arg Val Cys His Met Gly Val Cys Gln Gly Gln Gly Asp Thr Glu Asp 
225                 230                 235                 240 


Gly Arg Met Thr Leu Met Gly 
                245         


<210>  2010
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEND1__Homo_sapiens__NP_057648

<400>  2010

Met Glu Ser Arg Gly Lys Ser Ala Ser Ser Pro Lys Pro Asp Thr Lys 
1               5                   10                  15      


Val Pro Gln Val Thr Thr Glu Ala Lys Val Pro Pro Ala Ala Asp Gly 
            20                  25                  30          


Lys Ala Pro Leu Thr Lys Pro Ser Lys Lys Glu Ala Pro Ala Glu Lys 
        35                  40                  45              


Gln Gln Pro Pro Ala Ala Pro Thr Thr Ala Pro Ala Lys Lys Thr Ser 
    50                  55                  60                  


Ala Lys Ala Asp Pro Ala Leu Leu Asn Asn His Ser Asn Leu Lys Pro 
65                  70                  75                  80  


Ala Pro Thr Val Pro Ser Ser Pro Asp Ala Thr Pro Glu Pro Lys Gly 
                85                  90                  95      


Pro Gly Asp Gly Ala Glu Glu Asp Glu Ala Ala Ser Gly Gly Pro Gly 
            100                 105                 110         


Gly Arg Gly Pro Trp Ser Cys Glu Asn Phe Asn Pro Leu Leu Val Ala 
        115                 120                 125             


Gly Gly Val Ala Val Ala Ala Ile Ala Leu Ile Leu Gly Val Ala Phe 
    130                 135                 140                 


Leu Val Arg Lys Lys 
145                 


<210>  2011
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPA__Homo_sapiens__NP_001035891

<400>  2011

Met Gly Pro Arg Arg Arg Ser Arg Lys Pro Glu Ala Pro Arg Arg Arg 
1               5                   10                  15      


Ser Pro Ser Pro Thr Pro Thr Pro Gly Pro Ser Arg Arg Gly Pro Ser 
            20                  25                  30          


Leu Gly Ala Ser Ser His Gln His Ser Arg Arg Arg Gln Gly Trp Leu 
        35                  40                  45              


Lys Glu Ile Arg Lys Leu Gln Lys Ser Thr His Leu Leu Ile Arg Lys 
    50                  55                  60                  


Leu Pro Phe Ser Arg Leu Ala Ala Glu Ala Phe Leu Val His Leu Phe 
65                  70                  75                  80  


Glu Asp Ala Tyr Leu Leu Thr Leu His Ala Gly Arg Val Thr Leu Phe 
                85                  90                  95      


Pro Lys Asp Val Gln Leu Ala Arg Arg Ile Arg Gly Leu Glu Glu Gly 
            100                 105                 110         


Leu Gly 
        


<210>  2012
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPB__Homo_sapiens__NP_001801

<400>  2012

Met Gly Pro Lys Arg Arg Gln Leu Thr Phe Arg Glu Lys Ser Arg Ile 
1               5                   10                  15      


Ile Gln Glu Val Glu Glu Asn Pro Asp Leu Arg Lys Gly Glu Ile Ala 
            20                  25                  30          


Arg Arg Phe Asn Ile Pro Pro Ser Thr Leu Ser Thr Ile Leu Lys Asn 
        35                  40                  45              


Lys Arg Ala Ile Leu Ala Ser Glu Arg Lys Tyr Gly Val Ala Ser Thr 
    50                  55                  60                  


Cys Arg Lys Thr Asn Lys Leu Ser Pro Tyr Asp Lys Leu Glu Gly Leu 
65                  70                  75                  80  


Leu Ile Ala Trp Phe Gln Gln Ile Arg Ala Ala Gly Leu Pro Val Lys 
                85                  90                  95      


Gly Ile Ile Leu Lys Glu Lys Ala Leu Arg Ile Ala Glu Glu Leu Gly 
            100                 105                 110         


Met Asp Asp Phe Thr Ala Ser Asn Gly Trp Leu Asp Arg Phe Arg Arg 
        115                 120                 125             


Arg His Gly Val Val Ser Cys Ser Gly Val Ala Arg Ala Arg Ala Arg 
    130                 135                 140                 


Asn Ala Ala Pro Arg Thr Pro Ala Ala Pro Ala Ser Pro Ala Ala Val 
145                 150                 155                 160 


Pro Ser Glu Gly Ser Gly Gly Ser Thr Thr Gly Trp Arg Ala Arg Glu 
                165                 170                 175     


Glu Gln Pro Pro Ser Val Ala Glu Gly Tyr Ala Ser Gln Asp Val Phe 
            180                 185                 190         


Ser Ala Thr Glu Thr Ser Leu Trp Tyr Asp Phe Leu Pro Asp Gln Ala 
        195                 200                 205             


Ala Gly Leu Cys Gly Gly Asp Gly Arg Pro Arg Gln Ala Thr Gln Arg 
    210                 215                 220                 


Leu Ser Val Leu Leu Cys Ala Asn Ala Asp Gly Ser Glu Lys Leu Pro 
225                 230                 235                 240 


Pro Leu Val Ala Gly Lys Ser Ala Lys Pro Arg Ala Gly Gln Ala Gly 
                245                 250                 255     


Leu Pro Cys Asp Tyr Thr Ala Asn Ser Lys Gly Gly Val Thr Thr Gln 
            260                 265                 270         


Ala Leu Ala Lys Tyr Leu Lys Ala Leu Asp Thr Arg Met Ala Ala Glu 
        275                 280                 285             


Ser Arg Arg Val Leu Leu Leu Ala Gly Arg Leu Ala Ala Gln Ser Leu 
    290                 295                 300                 


Asp Thr Ser Gly Leu Arg His Val Gln Leu Ala Phe Phe Pro Pro Gly 
305                 310                 315                 320 


Thr Val His Pro Leu Glu Arg Gly Val Val Gln Gln Val Lys Gly His 
                325                 330                 335     


Tyr Arg Gln Ala Met Leu Leu Lys Ala Met Ala Ala Leu Glu Gly Gln 
            340                 345                 350         


Asp Pro Ser Gly Leu Gln Leu Gly Leu Thr Glu Ala Leu His Phe Val 
        355                 360                 365             


Ala Ala Ala Trp Gln Ala Val Glu Pro Ser Asp Ile Ala Ala Cys Phe 
    370                 375                 380                 


Arg Glu Ala Gly Phe Gly Gly Gly Pro Asn Ala Thr Ile Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Ser Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Glu Gly Glu Glu Leu Gly Glu Glu Glu Glu Val 
        435                 440                 445             


Glu Glu Glu Gly Asp Val Asp Ser Asp Glu Glu Glu Glu Glu Asp Glu 
    450                 455                 460                 


Glu Ser Ser Ser Glu Gly Leu Glu Ala Glu Asp Trp Ala Gln Gly Val 
465                 470                 475                 480 


Val Glu Ala Gly Gly Ser Phe Gly Ala Tyr Gly Ala Gln Glu Glu Ala 
                485                 490                 495     


Gln Cys Pro Thr Leu His Phe Leu Glu Gly Gly Glu Asp Ser Asp Ser 
            500                 505                 510         


Asp Ser Glu Glu Glu Asp Asp Glu Glu Glu Asp Asp Glu Asp Glu Asp 
        515                 520                 525             


Asp Asp Asp Asp Glu Glu Asp Gly Asp Glu Val Pro Val Pro Ser Phe 
    530                 535                 540                 


Gly Glu Ala Met Ala Tyr Phe Ala Met Val Lys Arg Tyr Leu Thr Ser 
545                 550                 555                 560 


Phe Pro Ile Asp Asp Arg Val Gln Ser His Ile Leu His Leu Glu His 
                565                 570                 575     


Asp Leu Val His Val Thr Arg Lys Asn His Ala Arg Gln Ala Gly Val 
            580                 585                 590         


Arg Gly Leu Gly His Gln Ser 
        595                 


<210>  2013
<211>  943
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPC__Homo_sapiens__NP_001803

<400>  2013

Met Ala Ala Ser Gly Leu Asp His Leu Lys Asn Gly Tyr Arg Arg Arg 
1               5                   10                  15      


Phe Cys Arg Pro Ser Arg Ala Arg Asp Ile Asn Thr Glu Gln Gly Gln 
            20                  25                  30          


Asn Val Leu Glu Ile Leu Gln Asp Cys Phe Glu Glu Lys Ser Leu Ala 
        35                  40                  45              


Asn Asp Phe Ser Thr Asn Ser Thr Lys Ser Val Pro Asn Ser Thr Arg 
    50                  55                  60                  


Lys Ile Lys Asp Thr Cys Ile Gln Ser Pro Ser Lys Glu Cys Gln Lys 
65                  70                  75                  80  


Ser His Pro Lys Ser Val Pro Val Ser Ser Lys Lys Lys Glu Ala Ser 
                85                  90                  95      


Leu Gln Phe Val Val Glu Pro Ser Glu Ala Thr Asn Arg Ser Val Gln 
            100                 105                 110         


Ala His Glu Val His Gln Lys Ile Leu Ala Thr Asp Val Ser Ser Lys 
        115                 120                 125             


Asn Thr Pro Asp Ser Lys Lys Ile Ser Ser Arg Asn Ile Asn Asp His 
    130                 135                 140                 


His Ser Glu Ala Asp Glu Glu Phe Tyr Leu Ser Val Gly Ser Pro Ser 
145                 150                 155                 160 


Val Leu Leu Asp Ala Lys Thr Ser Val Ser Gln Asn Val Ile Pro Ser 
                165                 170                 175     


Ser Ala Gln Lys Arg Glu Thr Tyr Thr Phe Glu Asn Ser Val Asn Met 
            180                 185                 190         


Leu Pro Ser Ser Thr Glu Val Ser Val Lys Thr Lys Lys Arg Leu Asn 
        195                 200                 205             


Phe Asp Asp Lys Val Met Leu Lys Lys Ile Glu Ile Asp Asn Lys Val 
    210                 215                 220                 


Ser Asp Glu Glu Asp Lys Thr Ser Glu Gly Gln Glu Arg Lys Pro Ser 
225                 230                 235                 240 


Gly Ser Ser Gln Asn Arg Ile Arg Asp Ser Glu Tyr Glu Ile Gln Arg 
                245                 250                 255     


Gln Ala Lys Lys Ser Phe Ser Thr Leu Phe Leu Glu Thr Val Lys Arg 
            260                 265                 270         


Lys Ser Glu Ser Ser Pro Ile Val Arg His Ala Ala Thr Ala Pro Pro 
        275                 280                 285             


His Ser Cys Pro Pro Asp Asp Thr Lys Leu Ile Glu Asp Glu Phe Ile 
    290                 295                 300                 


Ile Asp Glu Ser Asp Gln Ser Phe Ala Ser Arg Ser Trp Ile Thr Ile 
305                 310                 315                 320 


Pro Arg Lys Ala Gly Ser Leu Lys Gln Arg Thr Ile Ser Pro Ala Glu 
                325                 330                 335     


Ser Thr Ala Leu Leu Gln Gly Arg Lys Ser Arg Glu Lys His His Asn 
            340                 345                 350         


Ile Leu Pro Lys Thr Leu Ala Asn Asp Lys His Ser His Lys Pro His 
        355                 360                 365             


Pro Val Glu Thr Ser Gln Pro Ser Asp Lys Thr Val Leu Asp Thr Ser 
    370                 375                 380                 


Tyr Ala Leu Ile Gly Glu Thr Val Asn Asn Tyr Arg Ser Thr Lys Tyr 
385                 390                 395                 400 


Glu Met Tyr Ser Lys Asn Ala Glu Lys Pro Ser Arg Ser Lys Arg Thr 
                405                 410                 415     


Ile Lys Gln Lys Gln Arg Arg Lys Phe Met Ala Lys Pro Ala Glu Glu 
            420                 425                 430         


Gln Leu Asp Val Gly Gln Ser Lys Asp Glu Asn Ile His Thr Ser His 
        435                 440                 445             


Ile Thr Gln Asp Glu Phe Gln Arg Asn Ser Asp Arg Asn Met Glu Glu 
    450                 455                 460                 


His Glu Glu Met Gly Asn Asp Cys Val Ser Lys Lys Gln Met Pro Pro 
465                 470                 475                 480 


Val Gly Ser Lys Lys Ser Ser Thr Arg Lys Asp Lys Glu Glu Ser Lys 
                485                 490                 495     


Lys Lys Arg Phe Ser Ser Glu Ser Lys Asn Lys Leu Val Pro Glu Glu 
            500                 505                 510         


Val Thr Ser Thr Val Thr Lys Ser Arg Arg Ile Ser Arg Arg Pro Ser 
        515                 520                 525             


Asp Trp Trp Val Val Lys Ser Glu Glu Ser Pro Val Tyr Ser Asn Ser 
    530                 535                 540                 


Ser Val Arg Asn Glu Leu Pro Met His His Asn Ser Ser Arg Lys Ser 
545                 550                 555                 560 


Thr Lys Lys Thr Asn Gln Ser Ser Lys Asn Ile Arg Lys Lys Thr Ile 
                565                 570                 575     


Pro Leu Lys Arg Gln Lys Thr Ala Thr Lys Gly Asn Gln Arg Val Gln 
            580                 585                 590         


Lys Phe Leu Asn Ala Glu Gly Ser Gly Gly Ile Val Gly His Asp Glu 
        595                 600                 605             


Ile Ser Arg Cys Ser Leu Ser Glu Pro Leu Glu Ser Asp Glu Ala Asp 
    610                 615                 620                 


Leu Ala Lys Lys Lys Asn Leu Asp Cys Ser Arg Ser Thr Arg Ser Ser 
625                 630                 635                 640 


Lys Asn Glu Asp Asn Ile Met Thr Ala Gln Asn Val Pro Leu Lys Pro 
                645                 650                 655     


Gln Thr Ser Gly Tyr Thr Cys Asn Ile Pro Thr Glu Ser Asn Leu Asp 
            660                 665                 670         


Ser Gly Glu His Lys Thr Ser Val Leu Glu Glu Ser Gly Pro Ser Arg 
        675                 680                 685             


Leu Asn Asn Asn Tyr Leu Met Ser Gly Lys Asn Asp Val Asp Asp Glu 
    690                 695                 700                 


Glu Val His Gly Ser Ser Asp Asp Ser Lys Gln Ser Lys Val Ile Pro 
705                 710                 715                 720 


Lys Asn Arg Ile His His Lys Leu Val Leu Pro Ser Asn Thr Pro Asn 
                725                 730                 735     


Val Arg Arg Thr Lys Arg Thr Arg Leu Lys Pro Leu Glu Tyr Trp Arg 
            740                 745                 750         


Gly Glu Arg Ile Asp Tyr Gln Gly Arg Pro Ser Gly Gly Phe Val Ile 
        755                 760                 765             


Ser Gly Val Leu Ser Pro Asp Thr Ile Ser Ser Lys Arg Lys Ala Lys 
    770                 775                 780                 


Glu Asn Ile Gly Lys Val Asn Lys Lys Ser Asn Lys Lys Arg Ile Cys 
785                 790                 795                 800 


Leu Asp Asn Asp Glu Arg Lys Thr Asn Leu Met Val Asn Leu Gly Ile 
                805                 810                 815     


Pro Leu Gly Asp Pro Leu Gln Pro Thr Arg Val Lys Asp Pro Glu Thr 
            820                 825                 830         


Arg Glu Ile Ile Leu Met Asp Leu Val Arg Pro Gln Asp Thr Tyr Gln 
        835                 840                 845             


Phe Phe Val Lys His Gly Glu Leu Lys Val Tyr Lys Thr Leu Asp Thr 
    850                 855                 860                 


Pro Phe Phe Ser Thr Gly Lys Leu Ile Leu Gly Pro Gln Glu Glu Lys 
865                 870                 875                 880 


Gly Lys Gln His Val Gly Gln Asp Ile Leu Val Phe Tyr Val Asn Phe 
                885                 890                 895     


Gly Asp Leu Leu Cys Thr Leu His Glu Thr Pro Tyr Ile Leu Ser Thr 
            900                 905                 910         


Gly Asp Ser Phe Tyr Val Pro Ser Gly Asn Tyr Tyr Asn Ile Lys Asn 
        915                 920                 925             


Leu Arg Asn Glu Glu Ser Val Leu Leu Phe Thr Gln Ile Lys Arg 
    930                 935                 940             


<210>  2014
<211>  2580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPE__Homo_sapiens__NP_001273663

<400>  2014

Met Ala Glu Glu Gly Ala Val Ala Val Cys Val Arg Val Arg Pro Leu 
1               5                   10                  15      


Asn Ser Arg Glu Glu Ser Leu Gly Glu Thr Ala Gln Val Tyr Trp Lys 
            20                  25                  30          


Thr Asp Asn Asn Val Ile Tyr Gln Val Asp Gly Ser Lys Ser Phe Asn 
        35                  40                  45              


Phe Asp Arg Val Phe His Gly Asn Glu Thr Thr Lys Asn Val Tyr Glu 
    50                  55                  60                  


Glu Ile Ala Ala Pro Ile Ile Asp Ser Ala Ile Gln Gly Tyr Asn Gly 
65                  70                  75                  80  


Thr Ile Phe Ala Tyr Gly Gln Thr Ala Ser Gly Lys Thr Tyr Thr Met 
                85                  90                  95      


Met Gly Ser Glu Asp His Leu Gly Val Ile Pro Arg Ala Ile His Asp 
            100                 105                 110         


Ile Phe Gln Lys Ile Lys Lys Phe Pro Asp Arg Glu Phe Leu Leu Arg 
        115                 120                 125             


Val Ser Tyr Met Glu Ile Tyr Asn Glu Thr Ile Thr Asp Leu Leu Cys 
    130                 135                 140                 


Gly Thr Gln Lys Met Lys Pro Leu Ile Ile Arg Glu Asp Val Asn Arg 
145                 150                 155                 160 


Asn Val Tyr Val Ala Asp Leu Thr Glu Glu Val Val Tyr Thr Ser Glu 
                165                 170                 175     


Met Ala Leu Lys Trp Ile Thr Lys Gly Glu Lys Ser Arg His Tyr Gly 
            180                 185                 190         


Glu Thr Lys Met Asn Gln Arg Ser Ser Arg Ser His Thr Ile Phe Arg 
        195                 200                 205             


Met Ile Leu Glu Ser Arg Glu Lys Gly Glu Pro Ser Asn Cys Glu Gly 
    210                 215                 220                 


Ser Val Lys Val Ser His Leu Asn Leu Val Asp Leu Ala Gly Ser Glu 
225                 230                 235                 240 


Arg Ala Ala Gln Thr Gly Ala Ala Gly Val Arg Leu Lys Glu Gly Cys 
                245                 250                 255     


Asn Ile Asn Arg Ser Leu Phe Ile Leu Gly Gln Val Ile Lys Lys Leu 
            260                 265                 270         


Ser Asp Gly Gln Val Gly Gly Phe Ile Asn Tyr Arg Asp Ser Lys Leu 
        275                 280                 285             


Thr Arg Ile Leu Gln Asn Ser Leu Gly Gly Asn Ala Lys Thr Arg Ile 
    290                 295                 300                 


Ile Cys Thr Ile Thr Pro Val Ser Phe Asp Glu Thr Leu Thr Ala Leu 
305                 310                 315                 320 


Gln Phe Ala Ser Thr Ala Lys Tyr Met Lys Asn Thr Pro Tyr Val Asn 
                325                 330                 335     


Glu Val Ser Thr Asp Glu Ala Leu Leu Lys Arg Tyr Arg Lys Glu Ile 
            340                 345                 350         


Met Asp Leu Lys Lys Gln Leu Glu Glu Val Ser Leu Glu Thr Arg Ala 
        355                 360                 365             


Gln Ala Met Glu Lys Asp Gln Leu Ala Gln Leu Leu Glu Glu Lys Asp 
    370                 375                 380                 


Leu Leu Gln Lys Val Gln Asn Glu Lys Ile Glu Asn Leu Thr Arg Met 
385                 390                 395                 400 


Leu Val Thr Ser Ser Ser Leu Thr Leu Gln Gln Glu Leu Lys Ala Lys 
                405                 410                 415     


Arg Lys Arg Arg Val Thr Trp Cys Leu Gly Lys Ile Asn Lys Met Lys 
            420                 425                 430         


Asn Ser Asn Tyr Ala Asp Gln Phe Asn Ile Pro Thr Asn Ile Thr Thr 
        435                 440                 445             


Lys Thr His Lys Leu Ser Ile Asn Leu Leu Arg Glu Ile Asp Glu Ser 
    450                 455                 460                 


Val Cys Ser Glu Ser Asp Val Phe Ser Asn Thr Leu Asp Thr Leu Ser 
465                 470                 475                 480 


Glu Ile Glu Trp Asn Pro Ala Thr Lys Leu Leu Asn Gln Glu Asn Ile 
                485                 490                 495     


Glu Ser Glu Leu Asn Ser Leu Arg Ala Asp Tyr Asp Asn Leu Val Leu 
            500                 505                 510         


Asp Tyr Glu Gln Leu Arg Thr Glu Lys Glu Glu Met Glu Leu Lys Leu 
        515                 520                 525             


Lys Glu Lys Asn Asp Leu Asp Glu Phe Glu Ala Leu Glu Arg Lys Thr 
    530                 535                 540                 


Lys Lys Asp Gln Glu Asn Glu Leu Ser Ser Lys Val Glu Leu Leu Arg 
545                 550                 555                 560 


Glu Lys Glu Asp Gln Ile Lys Lys Leu Gln Glu Tyr Ile Asp Ser Gln 
                565                 570                 575     


Lys Leu Glu Asn Ile Lys Met Asp Leu Ser Tyr Ser Leu Glu Ser Ile 
            580                 585                 590         


Glu Asp Pro Lys Gln Met Lys Gln Thr Leu Phe Asp Ala Glu Thr Val 
        595                 600                 605             


Ala Leu Asp Ala Lys Arg Glu Ser Ala Phe Leu Arg Ser Glu Asn Leu 
    610                 615                 620                 


Glu Leu Lys Glu Lys Met Lys Glu Leu Ala Thr Thr Tyr Lys Gln Met 
625                 630                 635                 640 


Glu Asn Asp Ile Gln Leu Tyr Gln Ser Gln Leu Glu Ala Lys Lys Lys 
                645                 650                 655     


Met Gln Val Asp Leu Glu Lys Glu Leu Gln Ser Ala Phe Asn Glu Ile 
            660                 665                 670         


Thr Lys Leu Thr Ser Leu Ile Asp Gly Lys Val Pro Lys Asp Leu Leu 
        675                 680                 685             


Cys Asn Leu Glu Leu Glu Gly Lys Ile Thr Asp Leu Gln Lys Glu Leu 
    690                 695                 700                 


Asn Lys Glu Val Glu Glu Asn Glu Ala Leu Arg Glu Glu Val Ile Leu 
705                 710                 715                 720 


Leu Ser Glu Leu Lys Ser Leu Pro Ser Glu Val Glu Arg Leu Arg Lys 
                725                 730                 735     


Glu Ile Gln Asp Lys Ser Glu Glu Leu His Ile Ile Thr Ser Glu Lys 
            740                 745                 750         


Asp Lys Leu Phe Ser Glu Val Val His Lys Glu Ser Arg Val Gln Gly 
        755                 760                 765             


Leu Leu Glu Glu Ile Gly Lys Thr Lys Asp Asp Leu Ala Thr Thr Gln 
    770                 775                 780                 


Ser Asn Tyr Lys Ser Thr Asp Gln Glu Phe Gln Asn Phe Lys Thr Leu 
785                 790                 795                 800 


His Met Asp Phe Glu Gln Lys Tyr Lys Met Val Leu Glu Glu Asn Glu 
                805                 810                 815     


Arg Met Asn Gln Glu Ile Val Asn Leu Ser Lys Glu Ala Gln Lys Phe 
            820                 825                 830         


Asp Ser Ser Leu Gly Ala Leu Lys Thr Glu Leu Ser Tyr Lys Thr Gln 
        835                 840                 845             


Glu Leu Gln Glu Lys Thr Arg Glu Val Gln Glu Arg Leu Asn Glu Met 
    850                 855                 860                 


Glu Gln Leu Lys Glu Gln Leu Glu Asn Arg Asp Ser Thr Leu Gln Thr 
865                 870                 875                 880 


Val Glu Arg Glu Lys Thr Leu Ile Thr Glu Lys Leu Gln Gln Thr Leu 
                885                 890                 895     


Glu Glu Val Lys Thr Leu Thr Gln Glu Lys Asp Asp Leu Lys Gln Leu 
            900                 905                 910         


Gln Glu Ser Leu Gln Ile Glu Arg Asp Gln Leu Lys Ser Asp Ile His 
        915                 920                 925             


Asp Thr Val Asn Met Asn Ile Asp Thr Gln Glu Gln Leu Arg Asn Ala 
    930                 935                 940                 


Leu Glu Ser Leu Lys Gln His Gln Glu Thr Ile Asn Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Ile Ser Glu Glu Val Ser Arg Asn Leu His Met Glu Glu Asn Thr 
                965                 970                 975     


Gly Glu Thr Lys Asp Glu Phe Gln Gln Lys Met Val Gly Ile Asp Lys 
            980                 985                 990         


Lys Gln Asp Leu Glu Ala Lys Asn  Thr Gln Thr Leu Thr  Ala Asp Val 
        995                 1000                 1005             


Lys Asp  Asn Glu Ile Ile Glu  Gln Gln Arg Lys Ile  Phe Ser Leu 
    1010                 1015                 1020             


Ile Gln  Glu Lys Asn Glu Leu  Gln Gln Met Leu Glu  Ser Val Ile 
    1025                 1030                 1035             


Ala Glu  Lys Glu Gln Leu Lys  Thr Asp Leu Lys Glu  Asn Ile Glu 
    1040                 1045                 1050             


Met Thr  Ile Glu Asn Gln Glu  Glu Leu Arg Leu Leu  Gly Asp Glu 
    1055                 1060                 1065             


Leu Lys  Lys Gln Gln Glu Ile  Val Ala Gln Glu Lys  Asn His Ala 
    1070                 1075                 1080             


Ile Lys  Lys Glu Gly Glu Leu  Ser Arg Thr Cys Asp  Arg Leu Ala 
    1085                 1090                 1095             


Glu Val  Glu Glu Lys Leu Lys  Glu Lys Ser Gln Gln  Leu Gln Glu 
    1100                 1105                 1110             


Lys Gln  Gln Gln Leu Leu Asn  Val Gln Glu Glu Met  Ser Glu Met 
    1115                 1120                 1125             


Gln Lys  Lys Ile Asn Glu Ile  Glu Asn Leu Lys Asn  Glu Leu Lys 
    1130                 1135                 1140             


Asn Lys  Glu Leu Thr Leu Glu  His Met Glu Thr Glu  Arg Leu Glu 
    1145                 1150                 1155             


Leu Ala  Gln Lys Leu Asn Glu  Asn Tyr Glu Glu Val  Lys Ser Ile 
    1160                 1165                 1170             


Thr Lys  Glu Arg Lys Val Leu  Lys Glu Leu Gln Lys  Ser Phe Glu 
    1175                 1180                 1185             


Thr Glu  Arg Asp His Leu Arg  Gly Tyr Ile Arg Glu  Ile Glu Ala 
    1190                 1195                 1200             


Thr Gly  Leu Gln Thr Lys Glu  Glu Leu Lys Ile Ala  His Ile His 
    1205                 1210                 1215             


Leu Lys  Glu His Gln Glu Thr  Ile Asp Glu Leu Arg  Arg Ser Val 
    1220                 1225                 1230             


Ser Glu  Lys Thr Ala Gln Ile  Ile Asn Thr Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Ser His  Thr Lys Leu Gln Glu  Glu Ile Pro Val Leu  His Glu Glu 
    1250                 1255                 1260             


Gln Glu  Leu Leu Pro Asn Val  Lys Glu Val Ser Glu  Thr Gln Glu 
    1265                 1270                 1275             


Thr Met  Asn Glu Leu Glu Leu  Leu Thr Glu Gln Ser  Thr Thr Lys 
    1280                 1285                 1290             


Asp Ser  Thr Thr Leu Ala Arg  Ile Glu Met Glu Arg  Leu Arg Leu 
    1295                 1300                 1305             


Asn Glu  Lys Phe Gln Glu Ser  Gln Glu Glu Ile Lys  Ser Leu Thr 
    1310                 1315                 1320             


Lys Glu  Arg Asp Asn Leu Lys  Thr Ile Lys Glu Ala  Leu Glu Val 
    1325                 1330                 1335             


Lys His  Asp Gln Leu Lys Glu  His Ile Arg Glu Thr  Leu Ala Lys 
    1340                 1345                 1350             


Ile Gln  Glu Ser Gln Ser Lys  Gln Glu Gln Ser Leu  Asn Met Lys 
    1355                 1360                 1365             


Glu Lys  Asp Asn Glu Thr Thr  Lys Ile Val Ser Glu  Met Glu Gln 
    1370                 1375                 1380             


Phe Lys  Pro Lys Asp Ser Ala  Leu Leu Arg Ile Glu  Ile Glu Met 
    1385                 1390                 1395             


Leu Gly  Leu Ser Lys Arg Leu  Gln Glu Ser His Asp  Glu Met Lys 
    1400                 1405                 1410             


Ser Val  Ala Lys Glu Lys Asp  Asp Leu Gln Arg Leu  Gln Glu Val 
    1415                 1420                 1425             


Leu Gln  Ser Glu Ser Asp Gln  Leu Lys Glu Asn Ile  Lys Glu Ile 
    1430                 1435                 1440             


Val Ala  Lys His Leu Glu Thr  Glu Glu Glu Leu Lys  Val Ala His 
    1445                 1450                 1455             


Cys Cys  Leu Lys Glu Gln Glu  Glu Thr Ile Asn Glu  Leu Arg Val 
    1460                 1465                 1470             


Asn Leu  Ser Glu Lys Glu Thr  Glu Ile Ser Thr Ile  Gln Lys Gln 
    1475                 1480                 1485             


Leu Glu  Ala Ile Asn Asp Lys  Leu Gln Asn Lys Ile  Gln Glu Ile 
    1490                 1495                 1500             


Tyr Glu  Lys Glu Glu Gln Phe  Asn Ile Lys Gln Ile  Ser Glu Val 
    1505                 1510                 1515             


Gln Glu  Lys Val Asn Glu Leu  Lys Gln Phe Lys Glu  His Arg Lys 
    1520                 1525                 1530             


Ala Lys  Asp Ser Ala Leu Gln  Ser Ile Glu Ser Lys  Met Leu Glu 
    1535                 1540                 1545             


Leu Thr  Asn Arg Leu Gln Glu  Ser Gln Glu Glu Ile  Gln Ile Met 
    1550                 1555                 1560             


Ile Lys  Glu Lys Glu Glu Met  Lys Arg Val Gln Glu  Ala Leu Gln 
    1565                 1570                 1575             


Ile Glu  Arg Asp Gln Leu Lys  Glu Asn Thr Lys Glu  Ile Val Ala 
    1580                 1585                 1590             


Lys Met  Lys Glu Ser Gln Glu  Lys Glu Tyr Gln Phe  Leu Lys Met 
    1595                 1600                 1605             


Thr Ala  Val Asn Glu Thr Gln  Glu Lys Met Cys Glu  Ile Glu His 
    1610                 1615                 1620             


Leu Lys  Glu Gln Phe Glu Thr  Gln Lys Leu Asn Leu  Glu Asn Ile 
    1625                 1630                 1635             


Glu Thr  Glu Asn Ile Arg Leu  Thr Gln Ile Leu His  Glu Asn Leu 
    1640                 1645                 1650             


Glu Glu  Met Arg Ser Val Thr  Lys Glu Arg Asp Asp  Leu Arg Ser 
    1655                 1660                 1665             


Val Glu  Glu Thr Leu Lys Val  Glu Arg Asp Gln Leu  Lys Glu Asn 
    1670                 1675                 1680             


Leu Arg  Glu Thr Ile Thr Arg  Asp Leu Glu Lys Gln  Glu Glu Leu 
    1685                 1690                 1695             


Lys Ile  Val His Met His Leu  Lys Glu His Gln Glu  Thr Ile Asp 
    1700                 1705                 1710             


Lys Leu  Arg Gly Ile Val Ser  Glu Lys Thr Asn Glu  Ile Ser Asn 
    1715                 1720                 1725             


Met Gln  Lys Asp Leu Glu His  Ser Asn Asp Ala Leu  Lys Ala Gln 
    1730                 1735                 1740             


Asp Leu  Lys Ile Gln Glu Glu  Leu Arg Ile Ala His  Met His Leu 
    1745                 1750                 1755             


Lys Glu  Gln Gln Glu Thr Ile  Asp Lys Leu Arg Gly  Ile Val Ser 
    1760                 1765                 1770             


Glu Lys  Thr Asp Lys Leu Ser  Asn Met Gln Lys Asp  Leu Glu Asn 
    1775                 1780                 1785             


Ser Asn  Ala Lys Leu Gln Glu  Lys Ile Gln Glu Leu  Lys Ala Asn 
    1790                 1795                 1800             


Glu His  Gln Leu Ile Thr Leu  Lys Lys Asp Val Asn  Glu Thr Gln 
    1805                 1810                 1815             


Lys Lys  Val Ser Glu Met Glu  Gln Leu Lys Lys Gln  Ile Lys Asp 
    1820                 1825                 1830             


Gln Ser  Leu Thr Leu Ser Lys  Leu Glu Ile Glu Asn  Leu Asn Leu 
    1835                 1840                 1845             


Ala Gln  Lys Leu His Glu Asn  Leu Glu Glu Met Lys  Ser Val Met 
    1850                 1855                 1860             


Lys Glu  Arg Asp Asn Leu Arg  Arg Val Glu Glu Thr  Leu Lys Leu 
    1865                 1870                 1875             


Glu Arg  Asp Gln Leu Lys Glu  Ser Leu Gln Glu Thr  Lys Ala Arg 
    1880                 1885                 1890             


Asp Leu  Glu Ile Gln Gln Glu  Leu Lys Thr Ala Arg  Met Leu Ser 
    1895                 1900                 1905             


Lys Glu  His Lys Glu Thr Val  Asp Lys Leu Arg Glu  Lys Ile Ser 
    1910                 1915                 1920             


Glu Lys  Thr Ile Gln Ile Ser  Asp Ile Gln Lys Asp  Leu Asp Lys 
    1925                 1930                 1935             


Ser Lys  Asp Glu Leu Gln Lys  Lys Gln Asp Arg Gln  Asn His Gln 
    1940                 1945                 1950             


Val Lys  Pro Glu Lys Arg Leu  Leu Ser Asp Gly Gln  Gln His Leu 
    1955                 1960                 1965             


Thr Glu  Ser Leu Arg Glu Lys  Cys Ser Arg Ile Lys  Glu Leu Leu 
    1970                 1975                 1980             


Lys Arg  Tyr Ser Glu Met Asp  Asp His Tyr Glu Cys  Leu Asn Arg 
    1985                 1990                 1995             


Leu Ser  Leu Asp Leu Glu Lys  Glu Ile Glu Phe Gln  Lys Glu Leu 
    2000                 2005                 2010             


Ser Met  Arg Val Lys Ala Asn  Leu Ser Leu Pro Tyr  Leu Gln Thr 
    2015                 2020                 2025             


Lys His  Ile Glu Lys Leu Phe  Thr Ala Asn Gln Arg  Cys Ser Met 
    2030                 2035                 2040             


Glu Phe  His Arg Ile Met Lys  Lys Leu Lys Tyr Val  Leu Ser Tyr 
    2045                 2050                 2055             


Val Thr  Lys Ile Lys Glu Glu  Gln His Glu Ser Ile  Asn Lys Phe 
    2060                 2065                 2070             


Glu Met  Asp Phe Ile Asp Glu  Val Glu Lys Gln Lys  Glu Leu Leu 
    2075                 2080                 2085             


Ile Lys  Ile Gln His Leu Gln  Gln Asp Cys Asp Val  Pro Ser Arg 
    2090                 2095                 2100             


Glu Leu  Arg Asp Leu Lys Leu  Asn Gln Asn Met Asp  Leu His Ile 
    2105                 2110                 2115             


Glu Glu  Ile Leu Lys Asp Phe  Ser Glu Ser Glu Phe  Pro Ser Ile 
    2120                 2125                 2130             


Lys Thr  Glu Phe Gln Gln Val  Leu Ser Asn Arg Lys  Glu Met Thr 
    2135                 2140                 2145             


Gln Phe  Leu Glu Glu Trp Leu  Asn Thr Arg Phe Asp  Ile Glu Lys 
    2150                 2155                 2160             


Leu Lys  Asn Gly Ile Gln Lys  Glu Asn Asp Arg Ile  Cys Gln Val 
    2165                 2170                 2175             


Asn Asn  Phe Phe Asn Asn Arg  Ile Ile Ala Ile Met  Asn Glu Ser 
    2180                 2185                 2190             


Thr Glu  Phe Glu Glu Arg Ser  Ala Thr Ile Ser Lys  Glu Trp Glu 
    2195                 2200                 2205             


Gln Asp  Leu Lys Ser Leu Lys  Glu Lys Asn Glu Lys  Leu Phe Lys 
    2210                 2215                 2220             


Asn Tyr  Gln Thr Leu Lys Thr  Ser Leu Ala Ser Gly  Ala Gln Val 
    2225                 2230                 2235             


Asn Pro  Thr Thr Gln Asp Asn  Lys Asn Pro His Val  Thr Ser Arg 
    2240                 2245                 2250             


Ala Thr  Gln Leu Thr Thr Glu  Lys Ile Arg Glu Leu  Glu Asn Ser 
    2255                 2260                 2265             


Leu His  Glu Ala Lys Glu Ser  Ala Met His Lys Glu  Ser Lys Ile 
    2270                 2275                 2280             


Ile Lys  Met Gln Lys Glu Leu  Glu Val Thr Asn Asp  Ile Ile Ala 
    2285                 2290                 2295             


Lys Leu  Gln Ala Lys Val His  Glu Ser Asn Lys Cys  Leu Glu Lys 
    2300                 2305                 2310             


Thr Lys  Glu Thr Ile Gln Val  Leu Gln Asp Lys Val  Ala Leu Gly 
    2315                 2320                 2325             


Ala Lys  Pro Tyr Lys Glu Glu  Ile Glu Asp Leu Lys  Met Lys Leu 
    2330                 2335                 2340             


Val Lys  Ile Asp Leu Glu Lys  Met Lys Asn Ala Lys  Glu Phe Glu 
    2345                 2350                 2355             


Lys Glu  Ile Ser Ala Thr Lys  Ala Thr Val Glu Tyr  Gln Lys Glu 
    2360                 2365                 2370             


Val Ile  Arg Leu Leu Arg Glu  Asn Leu Arg Arg Ser  Gln Gln Ala 
    2375                 2380                 2385             


Gln Asp  Thr Ser Val Ile Ser  Glu His Thr Asp Pro  Gln Pro Ser 
    2390                 2395                 2400             


Asn Lys  Pro Leu Thr Cys Gly  Gly Gly Ser Gly Ile  Val Gln Asn 
    2405                 2410                 2415             


Thr Lys  Ala Leu Ile Leu Lys  Ser Glu His Ile Arg  Leu Glu Lys 
    2420                 2425                 2430             


Glu Ile  Ser Lys Leu Lys Gln  Gln Asn Glu Gln Leu  Ile Lys Gln 
    2435                 2440                 2445             


Lys Asn  Glu Leu Leu Ser Asn  Asn Gln His Leu Ser  Asn Glu Val 
    2450                 2455                 2460             


Lys Thr  Trp Lys Glu Arg Thr  Leu Lys Arg Glu Ala  His Lys Gln 
    2465                 2470                 2475             


Val Thr  Cys Glu Asn Ser Pro  Lys Ser Pro Lys Val  Thr Gly Thr 
    2480                 2485                 2490             


Ala Ser  Lys Lys Lys Gln Ile  Thr Pro Ser Gln Cys  Lys Glu Arg 
    2495                 2500                 2505             


Asn Leu  Gln Asp Pro Val Pro  Lys Glu Ser Pro Lys  Ser Cys Phe 
    2510                 2515                 2520             


Phe Asp  Ser Arg Ser Lys Ser  Leu Pro Ser Pro His  Pro Val Arg 
    2525                 2530                 2535             


Tyr Phe  Asp Asn Ser Ser Leu  Gly Leu Cys Pro Glu  Val Gln Asn 
    2540                 2545                 2550             


Ala Gly  Ala Glu Ser Val Asp  Ser Gln Pro Gly Pro  Trp His Ala 
    2555                 2560                 2565             


Ser Ser  Gly Lys Asp Val Pro  Glu Cys Lys Thr Gln  
    2570                 2575                 2580 


<210>  2015
<211>  3114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPF__Homo_sapiens__NP_057427

<400>  2015

Met Ser Trp Ala Leu Glu Glu Trp Lys Glu Gly Leu Pro Thr Arg Ala 
1               5                   10                  15      


Leu Gln Lys Ile Gln Glu Leu Glu Gly Gln Leu Asp Lys Leu Lys Lys 
            20                  25                  30          


Glu Lys Gln Gln Arg Gln Phe Gln Leu Asp Ser Leu Glu Ala Ala Leu 
        35                  40                  45              


Gln Lys Gln Lys Gln Lys Val Glu Asn Glu Lys Thr Glu Gly Thr Asn 
    50                  55                  60                  


Leu Lys Arg Glu Asn Gln Arg Leu Met Glu Ile Cys Glu Ser Leu Glu 
65                  70                  75                  80  


Lys Thr Lys Gln Lys Ile Ser His Glu Leu Gln Val Lys Glu Ser Gln 
                85                  90                  95      


Val Asn Phe Gln Glu Gly Gln Leu Asn Ser Gly Lys Lys Gln Ile Glu 
            100                 105                 110         


Lys Leu Glu Gln Glu Leu Lys Arg Cys Lys Ser Glu Leu Glu Arg Ser 
        115                 120                 125             


Gln Gln Ala Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Asn Thr 
    130                 135                 140                 


Pro Gln Lys Ile Phe Thr Thr Pro Leu Thr Pro Ser Gln Tyr Tyr Ser 
145                 150                 155                 160 


Gly Ser Lys Tyr Glu Asp Leu Lys Glu Lys Tyr Asn Lys Glu Val Glu 
                165                 170                 175     


Glu Arg Lys Arg Leu Glu Ala Glu Val Lys Ala Leu Gln Ala Lys Lys 
            180                 185                 190         


Ala Ser Gln Thr Leu Pro Gln Ala Thr Met Asn His Arg Asp Ile Ala 
        195                 200                 205             


Arg His Gln Ala Ser Ser Ser Val Phe Ser Trp Gln Gln Glu Lys Thr 
    210                 215                 220                 


Pro Ser His Leu Ser Ser Asn Ser Gln Arg Thr Pro Ile Arg Arg Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Tyr Phe Ser Gly Glu Gln Glu Val Thr Pro Ser Arg 
                245                 250                 255     


Ser Thr Leu Gln Ile Gly Lys Arg Asp Ala Asn Ser Ser Phe Phe Asp 
            260                 265                 270         


Asn Ser Ser Ser Pro His Leu Leu Asp Gln Leu Lys Ala Gln Asn Gln 
        275                 280                 285             


Glu Leu Arg Asn Lys Ile Asn Glu Leu Glu Leu Arg Leu Gln Gly His 
    290                 295                 300                 


Glu Lys Glu Met Lys Gly Gln Val Asn Lys Phe Gln Glu Leu Gln Leu 
305                 310                 315                 320 


Gln Leu Glu Lys Ala Lys Val Glu Leu Ile Glu Lys Glu Lys Val Leu 
                325                 330                 335     


Asn Lys Cys Arg Asp Glu Leu Val Arg Thr Thr Ala Gln Tyr Asp Gln 
            340                 345                 350         


Ala Ser Thr Lys Tyr Thr Ala Leu Glu Gln Lys Leu Lys Lys Leu Thr 
        355                 360                 365             


Glu Asp Leu Ser Cys Gln Arg Gln Asn Ala Glu Ser Ala Arg Cys Ser 
    370                 375                 380                 


Leu Glu Gln Lys Ile Lys Glu Lys Glu Lys Glu Phe Gln Glu Glu Leu 
385                 390                 395                 400 


Ser Arg Gln Gln Arg Ser Phe Gln Thr Leu Asp Gln Glu Cys Ile Gln 
                405                 410                 415     


Met Lys Ala Arg Leu Thr Gln Glu Leu Gln Gln Ala Lys Asn Met His 
            420                 425                 430         


Asn Val Leu Gln Ala Glu Leu Asp Lys Leu Thr Ser Val Lys Gln Gln 
        435                 440                 445             


Leu Glu Asn Asn Leu Glu Glu Phe Lys Gln Lys Leu Cys Arg Ala Glu 
    450                 455                 460                 


Gln Ala Phe Gln Ala Ser Gln Ile Lys Glu Asn Glu Leu Arg Arg Ser 
465                 470                 475                 480 


Met Glu Glu Met Lys Lys Glu Asn Asn Leu Leu Lys Ser His Ser Glu 
                485                 490                 495     


Gln Lys Ala Arg Glu Val Cys His Leu Glu Ala Glu Leu Lys Asn Ile 
            500                 505                 510         


Lys Gln Cys Leu Asn Gln Ser Gln Asn Phe Ala Glu Glu Met Lys Ala 
        515                 520                 525             


Lys Asn Thr Ser Gln Glu Thr Met Leu Arg Asp Leu Gln Glu Lys Ile 
    530                 535                 540                 


Asn Gln Gln Glu Asn Ser Leu Thr Leu Glu Lys Leu Lys Leu Ala Val 
545                 550                 555                 560 


Ala Asp Leu Glu Lys Gln Arg Asp Cys Ser Gln Asp Leu Leu Lys Lys 
                565                 570                 575     


Arg Glu His His Ile Glu Gln Leu Asn Asp Lys Leu Ser Lys Thr Glu 
            580                 585                 590         


Lys Glu Ser Lys Ala Leu Leu Ser Ala Leu Glu Leu Lys Lys Lys Glu 
        595                 600                 605             


Tyr Glu Glu Leu Lys Glu Glu Lys Thr Leu Phe Ser Cys Trp Lys Ser 
    610                 615                 620                 


Glu Asn Glu Lys Leu Leu Thr Gln Met Glu Ser Glu Lys Glu Asn Leu 
625                 630                 635                 640 


Gln Ser Lys Ile Asn His Leu Glu Thr Cys Leu Lys Thr Gln Gln Ile 
                645                 650                 655     


Lys Ser His Glu Tyr Asn Glu Arg Val Arg Thr Leu Glu Met Asp Arg 
            660                 665                 670         


Glu Asn Leu Ser Val Glu Ile Arg Asn Leu His Asn Val Leu Asp Ser 
        675                 680                 685             


Lys Ser Val Glu Val Glu Thr Gln Lys Leu Ala Tyr Met Glu Leu Gln 
    690                 695                 700                 


Gln Lys Ala Glu Phe Ser Asp Gln Lys His Gln Lys Glu Ile Glu Asn 
705                 710                 715                 720 


Met Cys Leu Lys Thr Ser Gln Leu Thr Gly Gln Val Glu Asp Leu Glu 
                725                 730                 735     


His Lys Leu Gln Leu Leu Ser Asn Glu Ile Met Asp Lys Asp Arg Cys 
            740                 745                 750         


Tyr Gln Asp Leu His Ala Glu Tyr Glu Ser Leu Arg Asp Leu Leu Lys 
        755                 760                 765             


Ser Lys Asp Ala Ser Leu Val Thr Asn Glu Asp His Gln Arg Ser Leu 
    770                 775                 780                 


Leu Ala Phe Asp Gln Gln Pro Ala Met His His Ser Phe Ala Asn Ile 
785                 790                 795                 800 


Ile Gly Glu Gln Gly Ser Met Pro Ser Glu Arg Ser Glu Cys Arg Leu 
                805                 810                 815     


Glu Ala Asp Gln Ser Pro Lys Asn Ser Ala Ile Leu Gln Asn Arg Val 
            820                 825                 830         


Asp Ser Leu Glu Phe Ser Leu Glu Ser Gln Lys Gln Met Asn Ser Asp 
        835                 840                 845             


Leu Gln Lys Gln Cys Glu Glu Leu Val Gln Ile Lys Gly Glu Ile Glu 
    850                 855                 860                 


Glu Asn Leu Met Lys Ala Glu Gln Met His Gln Ser Phe Val Ala Glu 
865                 870                 875                 880 


Thr Ser Gln Arg Ile Ser Lys Leu Gln Glu Asp Thr Ser Ala His Gln 
                885                 890                 895     


Asn Val Val Ala Glu Thr Leu Ser Ala Leu Glu Asn Lys Glu Lys Glu 
            900                 905                 910         


Leu Gln Leu Leu Asn Asp Lys Val Glu Thr Glu Gln Ala Glu Ile Gln 
        915                 920                 925             


Glu Leu Lys Lys Ser Asn His Leu Leu Glu Asp Ser Leu Lys Glu Leu 
    930                 935                 940                 


Gln Leu Leu Ser Glu Thr Leu Ser Leu Glu Lys Lys Glu Met Ser Ser 
945                 950                 955                 960 


Ile Ile Ser Leu Asn Lys Arg Glu Ile Glu Glu Leu Thr Gln Glu Asn 
                965                 970                 975     


Gly Thr Leu Lys Glu Ile Asn Ala Ser Leu Asn Gln Glu Lys Met Asn 
            980                 985                 990         


Leu Ile Gln Lys Ser Glu Ser Phe  Ala Asn Tyr Ile Asp  Glu Arg Glu 
        995                 1000                 1005             


Lys Ser  Ile Ser Glu Leu Ser  Asp Gln Tyr Lys Gln  Glu Lys Leu 
    1010                 1015                 1020             


Ile Leu  Leu Gln Arg Cys Glu  Glu Thr Gly Asn Ala  Tyr Glu Asp 
    1025                 1030                 1035             


Leu Ser  Gln Lys Tyr Lys Ala  Ala Gln Glu Lys Asn  Ser Lys Leu 
    1040                 1045                 1050             


Glu Cys  Leu Leu Asn Glu Cys  Thr Ser Leu Cys Glu  Asn Arg Lys 
    1055                 1060                 1065             


Asn Glu  Leu Glu Gln Leu Lys  Glu Ala Phe Ala Lys  Glu His Gln 
    1070                 1075                 1080             


Glu Phe  Leu Thr Lys Leu Ala  Phe Ala Glu Glu Arg  Asn Gln Asn 
    1085                 1090                 1095             


Leu Met  Leu Glu Leu Glu Thr  Val Gln Gln Ala Leu  Arg Ser Glu 
    1100                 1105                 1110             


Met Thr  Asp Asn Gln Asn Asn  Ser Lys Ser Glu Ala  Gly Gly Leu 
    1115                 1120                 1125             


Lys Gln  Glu Ile Met Thr Leu  Lys Glu Glu Gln Asn  Lys Met Gln 
    1130                 1135                 1140             


Lys Glu  Val Asn Asp Leu Leu  Gln Glu Asn Glu Gln  Leu Met Lys 
    1145                 1150                 1155             


Val Met  Lys Thr Lys His Glu  Cys Gln Asn Leu Glu  Ser Glu Pro 
    1160                 1165                 1170             


Ile Arg  Asn Ser Val Lys Glu  Arg Glu Ser Glu Arg  Asn Gln Cys 
    1175                 1180                 1185             


Asn Phe  Lys Pro Gln Met Asp  Leu Glu Val Lys Glu  Ile Ser Leu 
    1190                 1195                 1200             


Asp Ser  Tyr Asn Ala Gln Leu  Val Gln Leu Glu Ala  Met Leu Arg 
    1205                 1210                 1215             


Asn Lys  Glu Leu Lys Leu Gln  Glu Ser Glu Lys Glu  Lys Glu Cys 
    1220                 1225                 1230             


Leu Gln  His Glu Leu Gln Thr  Ile Arg Gly Asp Leu  Glu Thr Ser 
    1235                 1240                 1245             


Asn Leu  Gln Asp Met Gln Ser  Gln Glu Ile Ser Gly  Leu Lys Asp 
    1250                 1255                 1260             


Cys Glu  Ile Asp Ala Glu Glu  Lys Tyr Ile Ser Gly  Pro His Glu 
    1265                 1270                 1275             


Leu Ser  Thr Ser Gln Asn Asp  Asn Ala His Leu Gln  Cys Ser Leu 
    1280                 1285                 1290             


Gln Thr  Thr Met Asn Lys Leu  Asn Glu Leu Glu Lys  Ile Cys Glu 
    1295                 1300                 1305             


Ile Leu  Gln Ala Glu Lys Tyr  Glu Leu Val Thr Glu  Leu Asn Asp 
    1310                 1315                 1320             


Ser Arg  Ser Glu Cys Ile Thr  Ala Thr Arg Lys Met  Ala Glu Glu 
    1325                 1330                 1335             


Val Gly  Lys Leu Leu Asn Glu  Val Lys Ile Leu Asn  Asp Asp Ser 
    1340                 1345                 1350             


Gly Leu  Leu His Gly Glu Leu  Val Glu Asp Ile Pro  Gly Gly Glu 
    1355                 1360                 1365             


Phe Gly  Glu Gln Pro Asn Glu  Gln His Pro Val Ser  Leu Ala Pro 
    1370                 1375                 1380             


Leu Asp  Glu Ser Asn Ser Tyr  Glu His Leu Thr Leu  Ser Asp Lys 
    1385                 1390                 1395             


Glu Val  Gln Met His Phe Ala  Glu Leu Gln Glu Lys  Phe Leu Ser 
    1400                 1405                 1410             


Leu Gln  Ser Glu His Lys Ile  Leu His Asp Gln His  Cys Gln Met 
    1415                 1420                 1425             


Ser Ser  Lys Met Ser Glu Leu  Gln Thr Tyr Val Asp  Ser Leu Lys 
    1430                 1435                 1440             


Ala Glu  Asn Leu Val Leu Ser  Thr Asn Leu Arg Asn  Phe Gln Gly 
    1445                 1450                 1455             


Asp Leu  Val Lys Glu Met Gln  Leu Gly Leu Glu Glu  Gly Leu Val 
    1460                 1465                 1470             


Pro Ser  Leu Ser Ser Ser Cys  Val Pro Asp Ser Ser  Ser Leu Ser 
    1475                 1480                 1485             


Ser Leu  Gly Asp Ser Ser Phe  Tyr Arg Ala Leu Leu  Glu Gln Thr 
    1490                 1495                 1500             


Gly Asp  Met Ser Leu Leu Ser  Asn Leu Glu Gly Ala  Val Ser Ala 
    1505                 1510                 1515             


Asn Gln  Cys Ser Val Asp Glu  Val Phe Cys Ser Ser  Leu Gln Glu 
    1520                 1525                 1530             


Glu Asn  Leu Thr Arg Lys Glu  Thr Pro Ser Ala Pro  Ala Lys Gly 
    1535                 1540                 1545             


Val Glu  Glu Leu Glu Ser Leu  Cys Glu Val Tyr Arg  Gln Ser Leu 
    1550                 1555                 1560             


Glu Lys  Leu Glu Glu Lys Met  Glu Ser Gln Gly Ile  Met Lys Asn 
    1565                 1570                 1575             


Lys Glu  Ile Gln Glu Leu Glu  Gln Leu Leu Ser Ser  Glu Arg Gln 
    1580                 1585                 1590             


Glu Leu  Asp Cys Leu Arg Lys  Gln Tyr Leu Ser Glu  Asn Glu Gln 
    1595                 1600                 1605             


Trp Gln  Gln Lys Leu Thr Ser  Val Thr Leu Glu Met  Glu Ser Lys 
    1610                 1615                 1620             


Leu Ala  Ala Glu Lys Lys Gln  Thr Glu Gln Leu Ser  Leu Glu Leu 
    1625                 1630                 1635             


Glu Val  Ala Arg Leu Gln Leu  Gln Gly Leu Asp Leu  Ser Ser Arg 
    1640                 1645                 1650             


Ser Leu  Leu Gly Ile Asp Thr  Glu Asp Ala Ile Gln  Gly Arg Asn 
    1655                 1660                 1665             


Glu Ser  Cys Asp Ile Ser Lys  Glu His Thr Ser Glu  Thr Thr Glu 
    1670                 1675                 1680             


Arg Thr  Pro Lys His Asp Val  His Gln Ile Cys Asp  Lys Asp Ala 
    1685                 1690                 1695             


Gln Gln  Asp Leu Asn Leu Asp  Ile Glu Lys Ile Thr  Glu Thr Gly 
    1700                 1705                 1710             


Ala Val  Lys Pro Thr Gly Glu  Cys Ser Gly Glu Gln  Ser Pro Asp 
    1715                 1720                 1725             


Thr Asn  Tyr Glu Pro Pro Gly  Glu Asp Lys Thr Gln  Gly Ser Ser 
    1730                 1735                 1740             


Glu Cys  Ile Ser Glu Leu Ser  Phe Ser Gly Pro Asn  Ala Leu Val 
    1745                 1750                 1755             


Pro Met  Asp Phe Leu Gly Asn  Gln Glu Asp Ile His  Asn Leu Gln 
    1760                 1765                 1770             


Leu Arg  Val Lys Glu Thr Ser  Asn Glu Asn Leu Arg  Leu Leu His 
    1775                 1780                 1785             


Val Ile  Glu Asp Arg Asp Arg  Lys Val Glu Ser Leu  Leu Asn Glu 
    1790                 1795                 1800             


Met Lys  Glu Leu Asp Ser Lys  Leu His Leu Gln Glu  Val Gln Leu 
    1805                 1810                 1815             


Met Thr  Lys Ile Glu Ala Cys  Ile Glu Leu Glu Lys  Ile Val Gly 
    1820                 1825                 1830             


Glu Leu  Lys Lys Glu Asn Ser  Asp Leu Ser Glu Lys  Leu Glu Tyr 
    1835                 1840                 1845             


Phe Ser  Cys Asp His Gln Glu  Leu Leu Gln Arg Val  Glu Thr Ser 
    1850                 1855                 1860             


Glu Gly  Leu Asn Ser Asp Leu  Glu Met His Ala Asp  Lys Ser Ser 
    1865                 1870                 1875             


Arg Glu  Asp Ile Gly Asp Asn  Val Ala Lys Val Asn  Asp Ser Trp 
    1880                 1885                 1890             


Lys Glu  Arg Phe Leu Asp Val  Glu Asn Glu Leu Ser  Arg Ile Arg 
    1895                 1900                 1905             


Ser Glu  Lys Ala Ser Ile Glu  His Glu Ala Leu Tyr  Leu Glu Ala 
    1910                 1915                 1920             


Asp Leu  Glu Val Val Gln Thr  Glu Lys Leu Cys Leu  Glu Lys Asp 
    1925                 1930                 1935             


Asn Glu  Asn Lys Gln Lys Val  Ile Val Cys Leu Glu  Glu Glu Leu 
    1940                 1945                 1950             


Ser Val  Val Thr Ser Glu Arg  Asn Gln Leu Arg Gly  Glu Leu Asp 
    1955                 1960                 1965             


Thr Met  Ser Lys Lys Thr Thr  Ala Leu Asp Gln Leu  Ser Glu Lys 
    1970                 1975                 1980             


Met Lys  Glu Lys Thr Gln Glu  Leu Glu Ser His Gln  Ser Glu Cys 
    1985                 1990                 1995             


Leu His  Cys Ile Gln Val Ala  Glu Ala Glu Val Lys  Glu Lys Thr 
    2000                 2005                 2010             


Glu Leu  Leu Gln Thr Leu Ser  Ser Asp Val Ser Glu  Leu Leu Lys 
    2015                 2020                 2025             


Asp Lys  Thr His Leu Gln Glu  Lys Leu Gln Ser Leu  Glu Lys Asp 
    2030                 2035                 2040             


Ser Gln  Ala Leu Ser Leu Thr  Lys Cys Glu Leu Glu  Asn Gln Ile 
    2045                 2050                 2055             


Ala Gln  Leu Asn Lys Glu Lys  Glu Leu Leu Val Lys  Glu Ser Glu 
    2060                 2065                 2070             


Ser Leu  Gln Ala Arg Leu Ser  Glu Ser Asp Tyr Glu  Lys Leu Asn 
    2075                 2080                 2085             


Val Ser  Lys Ala Leu Glu Ala  Ala Leu Val Glu Lys  Gly Glu Phe 
    2090                 2095                 2100             


Ala Leu  Arg Leu Ser Ser Thr  Gln Glu Glu Val His  Gln Leu Arg 
    2105                 2110                 2115             


Arg Gly  Ile Glu Lys Leu Arg  Val Arg Ile Glu Ala  Asp Glu Lys 
    2120                 2125                 2130             


Lys Gln  Leu His Ile Ala Glu  Lys Leu Lys Glu Arg  Glu Arg Glu 
    2135                 2140                 2145             


Asn Asp  Ser Leu Lys Asp Lys  Val Glu Asn Leu Glu  Arg Glu Leu 
    2150                 2155                 2160             


Gln Met  Ser Glu Glu Asn Gln  Glu Leu Val Ile Leu  Asp Ala Glu 
    2165                 2170                 2175             


Asn Ser  Lys Ala Glu Val Glu  Thr Leu Lys Thr Gln  Ile Glu Glu 
    2180                 2185                 2190             


Met Ala  Arg Ser Leu Lys Val  Phe Glu Leu Asp Leu  Val Thr Leu 
    2195                 2200                 2205             


Arg Ser  Glu Lys Glu Asn Leu  Thr Lys Gln Ile Gln  Glu Lys Gln 
    2210                 2215                 2220             


Gly Gln  Leu Ser Glu Leu Asp  Lys Leu Leu Ser Ser  Phe Lys Ser 
    2225                 2230                 2235             


Leu Leu  Glu Glu Lys Glu Gln  Ala Glu Ile Gln Ile  Lys Glu Glu 
    2240                 2245                 2250             


Ser Lys  Thr Ala Val Glu Met  Leu Gln Asn Gln Leu  Lys Glu Leu 
    2255                 2260                 2265             


Asn Glu  Ala Val Ala Ala Leu  Cys Gly Asp Gln Glu  Ile Met Lys 
    2270                 2275                 2280             


Ala Thr  Glu Gln Ser Leu Asp  Pro Pro Ile Glu Glu  Glu His Gln 
    2285                 2290                 2295             


Leu Arg  Asn Ser Ile Glu Lys  Leu Arg Ala Arg Leu  Glu Ala Asp 
    2300                 2305                 2310             


Glu Lys  Lys Gln Leu Cys Val  Leu Gln Gln Leu Lys  Glu Ser Glu 
    2315                 2320                 2325             


His His  Ala Asp Leu Leu Lys  Gly Arg Val Glu Asn  Leu Glu Arg 
    2330                 2335                 2340             


Glu Leu  Glu Ile Ala Arg Thr  Asn Gln Glu His Ala  Ala Leu Glu 
    2345                 2350                 2355             


Ala Glu  Asn Ser Lys Gly Glu  Val Glu Thr Leu Lys  Ala Lys Ile 
    2360                 2365                 2370             


Glu Gly  Met Thr Gln Ser Leu  Arg Gly Leu Glu Leu  Asp Val Val 
    2375                 2380                 2385             


Thr Ile  Arg Ser Glu Lys Glu  Asn Leu Thr Asn Glu  Leu Gln Lys 
    2390                 2395                 2400             


Glu Gln  Glu Arg Ile Ser Glu  Leu Glu Ile Ile Asn  Ser Ser Phe 
    2405                 2410                 2415             


Glu Asn  Ile Leu Gln Glu Lys  Glu Gln Glu Lys Val  Gln Met Lys 
    2420                 2425                 2430             


Glu Lys  Ser Ser Thr Ala Met  Glu Met Leu Gln Thr  Gln Leu Lys 
    2435                 2440                 2445             


Glu Leu  Asn Glu Arg Val Ala  Ala Leu His Asn Asp  Gln Glu Ala 
    2450                 2455                 2460             


Cys Lys  Ala Lys Glu Gln Asn  Leu Ser Ser Gln Val  Glu Cys Leu 
    2465                 2470                 2475             


Glu Leu  Glu Lys Ala Gln Leu  Leu Gln Gly Leu Asp  Glu Ala Lys 
    2480                 2485                 2490             


Asn Asn  Tyr Ile Val Leu Gln  Ser Ser Val Asn Gly  Leu Ile Gln 
    2495                 2500                 2505             


Glu Val  Glu Asp Gly Lys Gln  Lys Leu Glu Lys Lys  Asp Glu Glu 
    2510                 2515                 2520             


Ile Ser  Arg Leu Lys Asn Gln  Ile Gln Asp Gln Glu  Gln Leu Val 
    2525                 2530                 2535             


Ser Lys  Leu Ser Gln Val Glu  Gly Glu His Gln Leu  Trp Lys Glu 
    2540                 2545                 2550             


Gln Asn  Leu Glu Leu Arg Asn  Leu Thr Val Glu Leu  Glu Gln Lys 
    2555                 2560                 2565             


Ile Gln  Val Leu Gln Ser Lys  Asn Ala Ser Leu Gln  Asp Thr Leu 
    2570                 2575                 2580             


Glu Val  Leu Gln Ser Ser Tyr  Lys Asn Leu Glu Asn  Glu Leu Glu 
    2585                 2590                 2595             


Leu Thr  Lys Met Asp Lys Met  Ser Phe Val Glu Lys  Val Asn Lys 
    2600                 2605                 2610             


Met Thr  Ala Lys Glu Thr Glu  Leu Gln Arg Glu Met  His Glu Met 
    2615                 2620                 2625             


Ala Gln  Lys Thr Ala Glu Leu  Gln Glu Glu Leu Ser  Gly Glu Lys 
    2630                 2635                 2640             


Asn Arg  Leu Ala Gly Glu Leu  Gln Leu Leu Leu Glu  Glu Ile Lys 
    2645                 2650                 2655             


Ser Ser  Lys Asp Gln Leu Lys  Glu Leu Thr Leu Glu  Asn Ser Glu 
    2660                 2665                 2670             


Leu Lys  Lys Ser Leu Asp Cys  Met His Lys Asp Gln  Val Glu Lys 
    2675                 2680                 2685             


Glu Gly  Lys Val Arg Glu Glu  Ile Ala Glu Tyr Gln  Leu Arg Leu 
    2690                 2695                 2700             


His Glu  Ala Glu Lys Lys His  Gln Ala Leu Leu Leu  Asp Thr Asn 
    2705                 2710                 2715             


Lys Gln  Tyr Glu Val Glu Ile  Gln Thr Tyr Arg Glu  Lys Leu Thr 
    2720                 2725                 2730             


Ser Lys  Glu Glu Cys Leu Ser  Ser Gln Lys Leu Glu  Ile Asp Leu 
    2735                 2740                 2745             


Leu Lys  Ser Ser Lys Glu Glu  Leu Asn Asn Ser Leu  Lys Ala Thr 
    2750                 2755                 2760             


Thr Gln  Ile Leu Glu Glu Leu  Lys Lys Thr Lys Met  Asp Asn Leu 
    2765                 2770                 2775             


Lys Tyr  Val Asn Gln Leu Lys  Lys Glu Asn Glu Arg  Ala Gln Gly 
    2780                 2785                 2790             


Lys Met  Lys Leu Leu Ile Lys  Ser Cys Lys Gln Leu  Glu Glu Glu 
    2795                 2800                 2805             


Lys Glu  Ile Leu Gln Lys Glu  Leu Ser Gln Leu Gln  Ala Ala Gln 
    2810                 2815                 2820             


Glu Lys  Gln Lys Thr Gly Thr  Val Met Asp Thr Lys  Val Asp Glu 
    2825                 2830                 2835             


Leu Thr  Thr Glu Ile Lys Glu  Leu Lys Glu Thr Leu  Glu Glu Lys 
    2840                 2845                 2850             


Thr Lys  Glu Ala Asp Glu Tyr  Leu Asp Lys Tyr Cys  Ser Leu Leu 
    2855                 2860                 2865             


Ile Ser  His Glu Lys Leu Glu  Lys Ala Lys Glu Met  Leu Glu Thr 
    2870                 2875                 2880             


Gln Val  Ala His Leu Cys Ser  Gln Gln Ser Lys Gln  Asp Ser Arg 
    2885                 2890                 2895             


Gly Ser  Pro Leu Leu Gly Pro  Val Val Pro Gly Pro  Ser Pro Ile 
    2900                 2905                 2910             


Pro Ser  Val Thr Glu Lys Arg  Leu Ser Ser Gly Gln  Asn Lys Ala 
    2915                 2920                 2925             


Ser Gly  Lys Arg Gln Arg Ser  Ser Gly Ile Trp Glu  Asn Gly Arg 
    2930                 2935                 2940             


Gly Pro  Thr Pro Ala Thr Pro  Glu Ser Phe Ser Lys  Lys Ser Lys 
    2945                 2950                 2955             


Lys Ala  Val Met Ser Gly Ile  His Pro Ala Glu Asp  Thr Glu Gly 
    2960                 2965                 2970             


Thr Glu  Phe Glu Pro Glu Gly  Leu Pro Glu Val Val  Lys Lys Gly 
    2975                 2980                 2985             


Phe Ala  Asp Ile Pro Thr Gly  Lys Thr Ser Pro Tyr  Ile Leu Arg 
    2990                 2995                 3000             


Arg Thr  Thr Met Ala Thr Arg  Thr Ser Pro Arg Leu  Ala Ala Gln 
    3005                 3010                 3015             


Lys Leu  Ala Leu Ser Pro Leu  Ser Leu Gly Lys Glu  Asn Leu Ala 
    3020                 3025                 3030             


Glu Ser  Ser Lys Pro Thr Ala  Gly Gly Ser Arg Ser  Gln Lys Val 
    3035                 3040                 3045             


Lys Val  Ala Gln Arg Ser Pro  Val Asp Ser Gly Thr  Ile Leu Arg 
    3050                 3055                 3060             


Glu Pro  Thr Thr Lys Ser Val  Pro Val Asn Asn Leu  Pro Glu Arg 
    3065                 3070                 3075             


Ser Pro  Thr Asp Ser Pro Arg  Glu Gly Leu Arg Val  Lys Arg Gly 
    3080                 3085                 3090             


Arg Leu  Val Pro Ser Pro Lys  Ala Gly Leu Glu Ser  Asn Gly Ser 
    3095                 3100                 3105             


Glu Asn  Cys Lys Val Gln 
    3110                 


<210>  2016
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPH__Homo_sapiens__NP_075060

<400>  2016

Met Glu Glu Gln Pro Gln Met Gln Asp Ala Asp Glu Pro Ala Asp Ser 
1               5                   10                  15      


Gly Gly Glu Gly Arg Ala Gly Gly Pro Pro Gln Val Ala Gly Ala Gln 
            20                  25                  30          


Ala Ala Cys Ser Glu Asp Arg Met Thr Leu Leu Leu Arg Leu Arg Ala 
        35                  40                  45              


Gln Thr Lys Gln Gln Leu Leu Glu Tyr Lys Ser Met Val Asp Ala Ser 
    50                  55                  60                  


Glu Glu Lys Thr Pro Glu Gln Ile Met Gln Glu Lys Gln Ile Glu Ala 
65                  70                  75                  80  


Lys Ile Glu Asp Leu Glu Asn Glu Ile Glu Glu Val Lys Val Ala Phe 
                85                  90                  95      


Glu Ile Lys Lys Leu Ala Leu Asp Arg Met Arg Leu Ser Thr Ala Leu 
            100                 105                 110         


Lys Lys Asn Leu Glu Lys Ile Ser Arg Gln Ser Ser Val Leu Met Asp 
        115                 120                 125             


Asn Met Lys His Leu Leu Glu Leu Asn Lys Leu Ile Met Lys Ser Gln 
    130                 135                 140                 


Gln Glu Ser Trp Asp Leu Glu Glu Lys Leu Leu Asp Ile Arg Lys Lys 
145                 150                 155                 160 


Arg Leu Gln Leu Lys Gln Ala Ser Glu Ser Lys Leu Leu Glu Ile Gln 
                165                 170                 175     


Thr Glu Lys Asn Lys Gln Lys Ile Asp Leu Asp Ser Met Glu Asn Ser 
            180                 185                 190         


Glu Arg Ile Lys Ile Ile Arg Gln Asn Leu Gln Met Glu Ile Lys Ile 
        195                 200                 205             


Thr Thr Val Ile Gln His Val Phe Gln Asn Leu Ile Leu Gly Ser Lys 
    210                 215                 220                 


Val Asn Trp Ala Glu Asp Pro Ala Leu Lys Glu Ile Val Leu Gln Leu 
225                 230                 235                 240 


Glu Lys Asn Val Asp Met Met 
                245         


<210>  2017
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPJ__Homo_sapiens__NP_060921

<400>  2017

Met Phe Leu Met Pro Thr Ser Ser Glu Leu Asn Ser Gly Gln Asn Phe 
1               5                   10                  15      


Leu Thr Gln Trp Met Thr Asn Pro Ser Arg Ala Gly Val Ile Leu Asn 
            20                  25                  30          


Arg Gly Phe Pro Ile Leu Glu Ala Asp Lys Glu Lys Arg Ala Ala Val 
        35                  40                  45              


Asp Ile Ser Thr Ser Phe Pro Ile Lys Gly Thr His Phe Ser Asp Ser 
    50                  55                  60                  


Phe Ser Phe Ile Asn Glu Glu Asp Ser Leu Leu Glu Glu Gln Lys Leu 
65                  70                  75                  80  


Glu Ser Asn Asn Pro Tyr Lys Pro Gln Ser Asp Lys Ser Glu Thr His 
                85                  90                  95      


Thr Ala Phe Pro Cys Ile Lys Lys Gly Pro Gln Val Ala Ala Cys His 
            100                 105                 110         


Ser Ala Pro Gly His Gln Glu Glu Asn Lys Asn Asp Phe Ile Pro Asp 
        115                 120                 125             


Leu Ala Ser Glu Phe Lys Glu Gly Ala Tyr Lys Asp Pro Leu Phe Lys 
    130                 135                 140                 


Lys Leu Glu Gln Leu Lys Glu Val Gln Gln Lys Lys Gln Glu Gln Leu 
145                 150                 155                 160 


Lys Arg Gln Gln Leu Glu Gln Leu Gln Arg Leu Met Glu Glu Gln Glu 
                165                 170                 175     


Lys Leu Leu Thr Met Val Ser Gly Gln Cys Thr Leu Pro Gly Leu Ser 
            180                 185                 190         


Leu Leu Pro Asp Asp Gln Ser Gln Lys His Arg Ser Pro Gly Asn Thr 
        195                 200                 205             


Thr Thr Gly Glu Arg Ala Thr Cys Cys Phe Pro Ser Tyr Val Tyr Pro 
    210                 215                 220                 


Asp Pro Thr Gln Glu Glu Thr Tyr Pro Ser Asn Ile Leu Ser His Glu 
225                 230                 235                 240 


Gln Ser Asn Phe Cys Arg Thr Ala His Gly Asp Phe Val Leu Thr Ser 
                245                 250                 255     


Lys Arg Ala Ser Pro Asn Leu Phe Ser Glu Ala Gln Tyr Gln Glu Ala 
            260                 265                 270         


Pro Val Glu Lys Asn Asn Leu Lys Glu Glu Asn Arg Asn His Pro Thr 
        275                 280                 285             


Gly Glu Ser Ile Leu Cys Trp Glu Lys Val Thr Glu Gln Ile Gln Glu 
    290                 295                 300                 


Ala Asn Asp Lys Asn Leu Gln Lys His Asp Asp Ser Ser Glu Val Ala 
305                 310                 315                 320 


Asn Ile Glu Glu Arg Pro Ile Lys Ala Ala Ile Gly Glu Arg Lys Gln 
                325                 330                 335     


Thr Phe Glu Asp Tyr Leu Glu Glu Gln Ile Gln Leu Glu Glu Gln Glu 
            340                 345                 350         


Leu Lys Gln Lys Gln Leu Lys Glu Ala Glu Gly Pro Leu Pro Ile Lys 
        355                 360                 365             


Ala Lys Pro Lys Gln Pro Phe Leu Lys Arg Gly Glu Gly Leu Ala Arg 
    370                 375                 380                 


Phe Thr Asn Ala Lys Ser Lys Phe Gln Lys Gly Lys Glu Ser Lys Leu 
385                 390                 395                 400 


Val Thr Asn Gln Ser Thr Ser Glu Asp Gln Pro Leu Phe Lys Met Asp 
                405                 410                 415     


Arg Gln Gln Leu Gln Arg Lys Thr Ala Leu Lys Asn Lys Glu Leu Cys 
            420                 425                 430         


Ala Asp Asn Pro Ile Leu Lys Lys Asp Ser Lys Ala Arg Thr Lys Ser 
        435                 440                 445             


Gly Ser Val Thr Leu Ser Gln Lys Pro Lys Met Leu Lys Cys Ser Asn 
    450                 455                 460                 


Arg Lys Ser Leu Ser Pro Ser Gly Leu Lys Ile Gln Thr Gly Lys Lys 
465                 470                 475                 480 


Cys Asp Gly Gln Phe Arg Asp Gln Ile Lys Phe Glu Asn Lys Val Thr 
                485                 490                 495     


Ser Asn Asn Lys Glu Asn Val Thr Glu Cys Pro Lys Pro Cys Asp Thr 
            500                 505                 510         


Gly Cys Thr Gly Trp Asn Lys Thr Gln Gly Lys Asp Arg Leu Pro Leu 
        515                 520                 525             


Ser Thr Gly Pro Ala Ser Arg Leu Ala Ala Lys Ser Pro Ile Arg Glu 
    530                 535                 540                 


Thr Met Lys Glu Ser Glu Ser Ser Leu Asp Val Ser Leu Gln Lys Lys 
545                 550                 555                 560 


Leu Glu Thr Trp Glu Arg Glu Lys Glu Lys Glu Asn Leu Glu Leu Asp 
                565                 570                 575     


Glu Phe Leu Phe Leu Glu Gln Ala Ala Asp Glu Ile Ser Phe Ser Ser 
            580                 585                 590         


Asn Ser Ser Phe Val Leu Lys Ile Leu Glu Arg Asp Gln Gln Ile Cys 
        595                 600                 605             


Lys Gly His Arg Met Ser Ser Thr Pro Val Lys Ala Val Pro Gln Lys 
    610                 615                 620                 


Thr Asn Pro Ala Asp Pro Ile Ser His Cys Asn Arg Ser Glu Asp Leu 
625                 630                 635                 640 


Asp His Thr Ala Arg Glu Lys Glu Ser Glu Cys Glu Val Ala Pro Lys 
                645                 650                 655     


Gln Leu His Ser Leu Ser Ser Ala Asp Glu Leu Arg Glu Gln Pro Cys 
            660                 665                 670         


Lys Ile Arg Lys Ala Val Gln Lys Ser Thr Ser Glu Asn Gln Thr Glu 
        675                 680                 685             


Trp Asn Ala Arg Asp Asp Glu Gly Val Pro Asn Ser Asp Ser Ser Thr 
    690                 695                 700                 


Asp Ser Glu Glu Gln Leu Asp Val Thr Ile Lys Pro Ser Thr Glu Asp 
705                 710                 715                 720 


Arg Glu Arg Gly Ile Ser Ser Arg Glu Asp Ser Pro Gln Val Cys Asp 
                725                 730                 735     


Asp Lys Gly Pro Phe Lys Asp Thr Arg Thr Gln Glu Asp Lys Arg Arg 
            740                 745                 750         


Asp Val Asp Leu Asp Leu Ser Asp Lys Asp Tyr Ser Ser Asp Glu Ser 
        755                 760                 765             


Ile Met Glu Ser Ile Lys His Lys Val Ser Glu Pro Ser Arg Ser Ser 
    770                 775                 780                 


Ser Leu Ser Leu Ser Lys Met Asp Phe Asp Asp Glu Arg Thr Trp Thr 
785                 790                 795                 800 


Asp Leu Glu Glu Asn Leu Cys Asn His Asp Val Val Leu Gly Asn Glu 
                805                 810                 815     


Ser Thr Tyr Gly Thr Pro Gln Thr Cys Tyr Pro Asn Asn Glu Ile Gly 
            820                 825                 830         


Ile Leu Asp Lys Thr Ile Lys Arg Lys Ile Ala Pro Val Lys Arg Gly 
        835                 840                 845             


Glu Asp Leu Ser Lys Ser Arg Arg Ser Arg Ser Pro Pro Thr Ser Glu 
    850                 855                 860                 


Leu Met Met Lys Phe Phe Pro Ser Leu Lys Pro Lys Pro Lys Ser Asp 
865                 870                 875                 880 


Ser His Leu Gly Asn Glu Leu Lys Leu Asn Ile Ser Gln Asp Gln Pro 
                885                 890                 895     


Pro Gly Asp Asn Ala Arg Ser Gln Val Leu Arg Glu Lys Ile Ile Glu 
            900                 905                 910         


Leu Glu Thr Glu Ile Glu Lys Phe Lys Ala Glu Asn Ala Ser Leu Ala 
        915                 920                 925             


Lys Leu Arg Ile Glu Arg Glu Ser Ala Leu Glu Lys Leu Arg Lys Glu 
    930                 935                 940                 


Ile Ala Asp Phe Glu Gln Gln Lys Ala Lys Glu Leu Ala Arg Ile Glu 
945                 950                 955                 960 


Glu Phe Lys Lys Glu Glu Met Arg Lys Leu Gln Lys Glu Arg Lys Val 
                965                 970                 975     


Phe Glu Lys Tyr Thr Thr Ala Ala Arg Thr Phe Pro Asp Lys Lys Glu 
            980                 985                 990         


Arg Glu Glu Ile Gln Thr Leu Lys  Gln Gln Ile Ala Asp  Leu Arg Glu 
        995                 1000                 1005             


Asp Leu  Lys Arg Lys Glu Thr  Lys Trp Ser Ser Thr  His Ser Arg 
    1010                 1015                 1020             


Leu Arg  Ser Gln Ile Gln Met  Leu Val Arg Glu Asn  Thr Asp Leu 
    1025                 1030                 1035             


Arg Glu  Glu Ile Lys Val Met  Glu Arg Phe Arg Leu  Asp Ala Trp 
    1040                 1045                 1050             


Lys Arg  Ala Glu Ala Ile Glu  Ser Ser Leu Glu Val  Glu Lys Lys 
    1055                 1060                 1065             


Asp Lys  Leu Ala Asn Thr Ser  Val Arg Phe Gln Asn  Ser Gln Ile 
    1070                 1075                 1080             


Ser Ser  Gly Thr Gln Val Glu  Lys Tyr Lys Lys Asn  Tyr Leu Pro 
    1085                 1090                 1095             


Met Gln  Gly Asn Pro Pro Arg  Arg Ser Lys Ser Ala  Pro Pro Arg 
    1100                 1105                 1110             


Asp Leu  Gly Asn Leu Asp Lys  Gly Gln Ala Ala Ser  Pro Arg Glu 
    1115                 1120                 1125             


Pro Leu  Glu Pro Leu Asn Phe  Pro Asp Pro Glu Tyr  Lys Glu Glu 
    1130                 1135                 1140             


Glu Glu  Asp Gln Asp Ile Gln  Gly Glu Ile Ser His  Pro Asp Gly 
    1145                 1150                 1155             


Lys Val  Glu Lys Val Tyr Lys  Asn Gly Cys Arg Val  Ile Leu Phe 
    1160                 1165                 1170             


Pro Asn  Gly Thr Arg Lys Glu  Val Ser Ala Asp Gly  Lys Thr Ile 
    1175                 1180                 1185             


Thr Val  Thr Phe Phe Asn Gly  Asp Val Lys Gln Val  Met Pro Asp 
    1190                 1195                 1200             


Gln Arg  Val Ile Tyr Tyr Tyr  Ala Ala Ala Gln Thr  Thr His Thr 
    1205                 1210                 1215             


Thr Tyr  Pro Glu Gly Leu Glu  Val Leu His Phe Ser  Ser Gly Gln 
    1220                 1225                 1230             


Ile Glu  Lys His Tyr Pro Asp  Gly Arg Lys Glu Ile  Thr Phe Pro 
    1235                 1240                 1245             


Asp Gln  Thr Val Lys Asn Leu  Phe Pro Asp Gly Gln  Glu Glu Ser 
    1250                 1255                 1260             


Ile Phe  Pro Asp Gly Thr Ile  Val Arg Val Gln Arg  Asp Gly Asn 
    1265                 1270                 1275             


Lys Leu  Ile Glu Phe Asn Asn  Gly Gln Arg Glu Leu  His Thr Ala 
    1280                 1285                 1290             


Gln Phe  Lys Arg Arg Glu Tyr  Pro Asp Gly Thr Val  Lys Thr Val 
    1295                 1300                 1305             


Tyr Ala  Asn Gly His Gln Glu  Thr Lys Tyr Arg Ser  Gly Arg Ile 
    1310                 1315                 1320             


Arg Val  Lys Asp Lys Glu Gly  Asn Val Leu Met Asp  Thr Glu Leu 
    1325                 1330                 1335             


<210>  2018
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPK__Homo_sapiens__NP_001253967

<400>  2018

Met Asn Gln Glu Asp Leu Asp Pro Asp Ser Thr Thr Asp Val Gly Asp 
1               5                   10                  15      


Val Thr Asn Thr Glu Glu Glu Leu Ile Arg Glu Cys Glu Glu Met Trp 
            20                  25                  30          


Lys Asp Met Glu Glu Cys Gln Asn Lys Leu Ser Leu Ile Gly Thr Glu 
        35                  40                  45              


Thr Leu Thr Asp Ser Asn Ala Gln Leu Ser Leu Leu Ile Met Gln Val 
    50                  55                  60                  


Lys Cys Leu Thr Ala Glu Leu Ser Gln Trp Gln Lys Lys Thr Pro Glu 
65                  70                  75                  80  


Thr Ile Pro Leu Thr Glu Asp Val Leu Ile Thr Leu Gly Lys Glu Glu 
                85                  90                  95      


Phe Gln Lys Leu Arg Gln Asp Leu Glu Met Val Leu Ser Thr Lys Glu 
            100                 105                 110         


Ser Lys Asn Glu Lys Leu Lys Glu Asp Leu Glu Arg Glu Gln Arg Trp 
        115                 120                 125             


Leu Asp Glu Gln Gln Gln Ile Met Glu Ser Leu Asn Val Leu His Ser 
    130                 135                 140                 


Glu Leu Lys Asn Lys Val Glu Thr Phe Ser Glu Ser Arg Ile Phe Asn 
145                 150                 155                 160 


Glu Leu Lys Thr Lys Met Leu Asn Ile Lys Glu Tyr Lys Glu Lys Leu 
                165                 170                 175     


Leu Ser Thr Leu Gly Glu Phe Leu Glu Asp His Phe Pro Leu Pro Asp 
            180                 185                 190         


Arg Ser Val Lys Lys Lys Lys Lys Asn Ile Gln Glu Ser Ser Val Asn 
        195                 200                 205             


Leu Ile Thr Leu His Glu Met Leu Glu Ile Leu Ile Asn Arg Leu Phe 
    210                 215                 220                 


Asp Val Pro His Asp Pro Tyr Val Lys Ile Ser Asp Ser Phe Trp Pro 
225                 230                 235                 240 


Pro Tyr Val Glu Leu Leu Leu Arg Asn Gly Ile Ala Leu Arg His Pro 
                245                 250                 255     


Glu Asp Pro Thr Arg Ile Arg Leu Glu Ala Phe His Gln 
            260                 265                 


<210>  2019
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPN__Homo_sapiens__NP_001094095

<400>  2019

Met Asp Glu Thr Val Ala Glu Phe Ile Lys Arg Thr Ile Leu Lys Ile 
1               5                   10                  15      


Pro Met Asn Glu Leu Thr Thr Ile Leu Lys Ala Trp Asp Phe Leu Ser 
            20                  25                  30          


Glu Asn Gln Leu Gln Thr Val Asn Phe Arg Gln Arg Lys Glu Ser Val 
        35                  40                  45              


Val Gln His Leu Ile His Leu Cys Glu Glu Lys Arg Ala Ser Ile Ser 
    50                  55                  60                  


Asp Ala Ala Leu Leu Asp Ile Ile Tyr Met Gln Phe His Gln His Gln 
65                  70                  75                  80  


Lys Val Trp Glu Val Phe Gln Met Ser Lys Gly Pro Gly Glu Asp Val 
                85                  90                  95      


Asp Leu Phe Asp Met Lys Gln Phe Lys Asn Ser Phe Lys Lys Ile Leu 
            100                 105                 110         


Gln Arg Ala Leu Lys Asn Val Thr Val Ser Phe Arg Glu Thr Glu Glu 
        115                 120                 125             


Asn Ala Val Trp Ile Arg Ile Ala Trp Gly Thr Gln Tyr Thr Lys Pro 
    130                 135                 140                 


Asn Gln Tyr Lys Pro Thr Tyr Val Val Tyr Tyr Ser Gln Thr Pro Tyr 
145                 150                 155                 160 


Ala Phe Thr Ser Ser Ser Met Leu Arg Arg Asn Thr Pro Leu Leu Gly 
                165                 170                 175     


Gln Ala Leu Thr Ile Ala Ser Lys His His Gln Ile Val Lys Met Asp 
            180                 185                 190         


Leu Arg Ser Arg Tyr Leu Asp Ser Leu Lys Ala Ile Val Phe Lys Gln 
        195                 200                 205             


Tyr Asn Gln Thr Phe Glu Thr His Asn Ser Thr Thr Pro Leu Gln Glu 
    210                 215                 220                 


Arg Ser Leu Gly Leu Asp Ile Asn Met Asp Ser Arg Ile Ile His Glu 
225                 230                 235                 240 


Asn Ile Val Glu Lys Glu Arg Val Gln Arg Ile Thr Gln Glu Thr Phe 
                245                 250                 255     


Gly Asp Tyr Pro Gln Pro Gln Leu Glu Phe Ala Gln Tyr Lys Leu Glu 
            260                 265                 270         


Thr Lys Phe Lys Ser Gly Leu Asn Gly Ser Ile Leu Ala Glu Arg Glu 
        275                 280                 285             


Glu Pro Leu Arg Cys Leu Ile Lys Phe Ser Ser Pro His Leu Leu Glu 
    290                 295                 300                 


Ala Leu Lys Ser Leu Ala Pro Ala Ala Leu Val Cys Arg Ile Gln Lys 
305                 310                 315                 320 


Leu Leu Cys Tyr Ser Gly Ser His Ser Gln Gly Thr Gln Asp Pro Ser 
                325                 330                 335     


Ser Trp Gln Lys Asp Leu Tyr Leu Leu Phe Val Pro Leu Tyr Pro Arg 
            340                 345                 350         


Cys 
    


<210>  2020
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPO__Homo_sapiens__NP_001186732

<400>  2020

Met Ala Gly Ile Leu Ala Ser Gly Leu Gly Val Leu Ala His Leu Glu 
1               5                   10                  15      


Arg Leu Glu Thr Gln Val Ser Arg Ser Arg Lys Gln Ser Glu Glu Leu 
            20                  25                  30          


Gln Ser Val Gln Ala Gln Glu Gly Ala Leu Gly Thr Lys Ile His Lys 
        35                  40                  45              


Leu Arg Arg Leu Arg Asp Glu Leu Arg Ala Val Val Arg His Arg Arg 
    50                  55                  60                  


Ala Ser Val Lys Ala Cys Ile Ala Asn Val Glu Pro Asn Gln Thr Val 
65                  70                  75                  80  


Glu Ile Asn Glu Gln Glu Ala Leu Glu Glu Lys Leu Glu Asn Val Lys 
                85                  90                  95      


Ala Ile Leu Gln Ala Tyr His Phe Thr Gly Leu Ser Gly Lys Leu Thr 
            100                 105                 110         


Ser Arg Gly Val Cys Val Cys Ile Ser Thr Ala Phe Glu Gly Asn Leu 
        115                 120                 125             


Leu Asp Ser Tyr Phe Val Asp Leu Val Ile Gln Lys Pro Leu Arg Ile 
    130                 135                 140                 


His His His Ser Val Pro Val Phe Ile Pro Leu Glu Glu Ile Ala Ala 
145                 150                 155                 160 


Lys Tyr Leu Gln Thr Asn Ile Gln His Phe Leu Phe Ser Leu Cys Glu 
                165                 170                 175     


Tyr Leu Asn Ala Tyr Ser Gly Arg Lys Tyr Gln Ala Asp Arg Leu Gln 
            180                 185                 190         


Ser Asp Phe Ala Ala Leu Leu Thr Gly Pro Leu Gln Arg Asn Pro Leu 
        195                 200                 205             


Cys Asn Leu Leu Ser Phe Thr Tyr Lys Leu Asp Pro Gly Gly Gln Ser 
    210                 215                 220                 


Phe Pro Phe Cys Ala Arg Leu Leu Tyr Lys Asp Leu Thr Ala Thr Leu 
225                 230                 235                 240 


Pro Thr Asp Val Thr Val Thr Cys Gln Gly Val Glu Val Leu Ser Thr 
                245                 250                 255     


Ser Trp Glu Glu Gln Arg Ala Ser His Glu Thr Leu Phe Cys Thr Lys 
            260                 265                 270         


Pro Leu His Gln Val Phe Ala Ser Phe Thr Arg Lys Gly Glu Lys Leu 
        275                 280                 285             


Asp Met Ser Leu Val Ser 
    290                 


<210>  2021
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPQ__Homo_sapiens__NP_060602

<400>  2021

Met Ser Gly Lys Ala Asn Ala Ser Lys Lys Asn Ala Gln Gln Leu Lys 
1               5                   10                  15      


Arg Asn Pro Lys Arg Lys Lys Asp Asn Glu Glu Val Val Leu Ser Glu 
            20                  25                  30          


Asn Lys Val Arg Asn Thr Val Lys Lys Asn Lys Asn His Leu Lys Asp 
        35                  40                  45              


Leu Ser Ser Glu Gly Gln Thr Lys His Thr Asn Leu Lys His Gly Lys 
    50                  55                  60                  


Thr Ala Ala Ser Lys Arg Lys Thr Trp Gln Pro Leu Ser Lys Ser Thr 
65                  70                  75                  80  


Arg Asp His Leu Gln Thr Met Met Glu Ser Val Ile Met Thr Ile Leu 
                85                  90                  95      


Ser Asn Ser Ile Lys Glu Lys Glu Glu Ile Gln Tyr His Leu Asn Phe 
            100                 105                 110         


Leu Lys Lys Arg Leu Leu Gln Gln Cys Glu Thr Leu Lys Val Pro Pro 
        115                 120                 125             


Lys Lys Met Glu Asp Leu Thr Asn Val Ser Ser Leu Leu Asn Met Glu 
    130                 135                 140                 


Arg Ala Arg Asp Lys Ala Asn Glu Glu Gly Leu Ala Leu Leu Gln Glu 
145                 150                 155                 160 


Glu Ile Asp Lys Met Val Glu Thr Thr Glu Leu Met Thr Gly Asn Ile 
                165                 170                 175     


Gln Ser Leu Lys Asn Lys Ile Gln Ile Leu Ala Ser Glu Val Glu Glu 
            180                 185                 190         


Glu Glu Glu Arg Val Lys Gln Met His Gln Ile Asn Ser Ser Gly Val 
        195                 200                 205             


Leu Ser Leu Pro Glu Leu Ser Gln Lys Thr Leu Lys Ala Pro Thr Leu 
    210                 215                 220                 


Gln Lys Glu Ile Leu Ala Leu Ile Pro Asn Gln Asn Ala Leu Leu Lys 
225                 230                 235                 240 


Asp Leu Asp Ile Leu His Asn Ser Ser Gln Met Lys Ser Met Ser Thr 
                245                 250                 255     


Phe Ile Glu Glu Ala Tyr Lys Lys Leu Asp Ala Ser 
            260                 265             


<210>  2022
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPU__Homo_sapiens__NP_078905

<400>  2022

Met Ala Pro Arg Gly Arg Arg Arg Pro Arg Pro His Arg Ser Glu Gly 
1               5                   10                  15      


Ala Arg Arg Ser Lys Asn Thr Leu Glu Arg Thr His Ser Met Lys Asp 
            20                  25                  30          


Lys Ala Gly Gln Lys Cys Lys Pro Ile Asp Val Phe Asp Phe Pro Asp 
        35                  40                  45              


Asn Ser Asp Val Ser Ser Ile Gly Arg Leu Gly Glu Asn Glu Lys Asp 
    50                  55                  60                  


Glu Glu Thr Tyr Glu Thr Phe Asp Pro Pro Leu His Ser Thr Ala Ile 
65                  70                  75                  80  


Tyr Ala Asp Glu Glu Glu Phe Ser Lys His Cys Gly Leu Ser Leu Ser 
                85                  90                  95      


Ser Thr Pro Pro Gly Lys Glu Ala Lys Arg Ser Ser Asp Thr Ser Gly 
            100                 105                 110         


Asn Glu Ala Ser Glu Ile Glu Ser Val Lys Ile Ser Ala Lys Lys Pro 
        115                 120                 125             


Gly Arg Lys Leu Arg Pro Ile Ser Asp Asp Ser Glu Ser Ile Glu Glu 
    130                 135                 140                 


Ser Asp Thr Arg Arg Lys Val Lys Ser Ala Glu Lys Ile Ser Thr Gln 
145                 150                 155                 160 


Arg His Glu Val Ile Arg Thr Thr Ala Ser Ser Glu Leu Ser Glu Lys 
                165                 170                 175     


Pro Ala Glu Ser Val Thr Ser Lys Lys Thr Gly Pro Leu Ser Ala Gln 
            180                 185                 190         


Pro Ser Val Glu Lys Glu Asn Leu Ala Ile Glu Ser Gln Ser Lys Thr 
        195                 200                 205             


Gln Lys Lys Gly Lys Ile Ser His Asp Lys Arg Lys Lys Ser Arg Ser 
    210                 215                 220                 


Lys Ala Ile Gly Ser Asp Thr Ser Asp Ile Val His Ile Trp Cys Pro 
225                 230                 235                 240 


Glu Gly Met Lys Thr Ser Asp Ile Lys Glu Leu Asn Ile Val Leu Pro 
                245                 250                 255     


Glu Phe Glu Lys Thr His Leu Glu His Gln Gln Arg Ile Glu Ser Lys 
            260                 265                 270         


Val Cys Lys Ala Ala Ile Ala Thr Phe Tyr Val Asn Val Lys Glu Gln 
        275                 280                 285             


Phe Ile Lys Met Leu Lys Glu Ser Gln Met Leu Thr Asn Leu Lys Arg 
    290                 295                 300                 


Lys Asn Ala Lys Met Ile Ser Asp Ile Glu Lys Lys Arg Gln Arg Met 
305                 310                 315                 320 


Ile Glu Val Gln Asp Glu Leu Leu Arg Leu Glu Pro Gln Leu Lys Gln 
                325                 330                 335     


Leu Gln Thr Lys Tyr Asp Glu Leu Lys Glu Arg Lys Ser Ser Leu Arg 
            340                 345                 350         


Asn Ala Ala Tyr Phe Leu Ser Asn Leu Lys Gln Leu Tyr Gln Asp Tyr 
        355                 360                 365             


Ser Asp Val Gln Ala Gln Glu Pro Asn Val Lys Glu Thr Tyr Asp Ser 
    370                 375                 380                 


Ser Ser Leu Pro Ala Leu Leu Phe Lys Ala Arg Thr Leu Leu Gly Ala 
385                 390                 395                 400 


Glu Ser His Leu Arg Asn Ile Asn His Gln Leu Glu Lys Leu Leu Asp 
                405                 410                 415     


Gln Gly 
        


<210>  2023
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPV__Homo_sapiens__NP_859067

<400>  2023

Met Arg Arg Ser Arg Ser Ser Ala Ala Ala Lys Leu Arg Gly Gln Lys 
1               5                   10                  15      


Arg Ser Gly Ala Ser Ala Ala Pro Ala Ala Ser Ala Ala Ala Ala Leu 
            20                  25                  30          


Ala Pro Ser Ala Thr Arg Thr Arg Arg Ser Ala Ser Gln Ala Gly Ser 
        35                  40                  45              


Lys Ser Gln Ala Val Glu Lys Pro Pro Ser Glu Lys Pro Arg Leu Arg 
    50                  55                  60                  


Arg Ser Ser Pro Arg Ala Gln Glu Glu Gly Pro Gly Glu Pro Pro Pro 
65                  70                  75                  80  


Pro Glu Leu Ala Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro Thr Pro 
                85                  90                  95      


Ala Thr Pro Thr Ser Ser Ala Ser Asn Leu Asp Leu Gly Glu Gln Arg 
            100                 105                 110         


Glu Arg Trp Glu Thr Phe Gln Lys Arg Gln Lys Leu Thr Ser Glu Gly 
        115                 120                 125             


Ala Ala Lys Leu Leu Leu Asp Thr Phe Glu Tyr Gln Gly Leu Val Lys 
    130                 135                 140                 


His Thr Gly Gly Cys His Cys Gly Ala Val Arg Phe Glu Val Trp Ala 
145                 150                 155                 160 


Ser Ala Asp Leu His Ile Phe Asp Cys Asn Cys Ser Ile Cys Lys Lys 
                165                 170                 175     


Lys Gln Asn Arg His Phe Ile Val Pro Ala Ser Arg Phe Lys Leu Leu 
            180                 185                 190         


Lys Gly Ala Glu His Ile Thr Thr Tyr Thr Phe Asn Thr His Lys Ala 
        195                 200                 205             


Gln His Thr Phe Cys Lys Arg Cys Gly Val Gln Ser Phe Tyr Thr Pro 
    210                 215                 220                 


Arg Ser Asn Pro Gly Gly Phe Gly Ile Ala Pro His Cys Leu Asp Glu 
225                 230                 235                 240 


Gly Thr Val Arg Ser Met Val Thr Glu Glu Phe Asn Gly Ser Asp Trp 
                245                 250                 255     


Glu Lys Ala Met Lys Glu His Lys Thr Ile Lys Asn Met Ser Lys Glu 
            260                 265                 270         


<210>  2024
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CENPW__Homo_sapiens__NP_001012525

<400>  2024

Met Ala Leu Ser Thr Ile Val Ser Gln Arg Lys Gln Ile Lys Arg Lys 
1               5                   10                  15      


Ala Pro Arg Gly Phe Leu Lys Arg Val Phe Lys Arg Lys Lys Pro Gln 
            20                  25                  30          


Leu Arg Leu Glu Lys Ser Gly Asp Leu Leu Val His Leu Asn Cys Leu 
        35                  40                  45              


Leu Phe Val His Arg Leu Ala Glu Glu Ser Arg Thr Asn Ala Cys Ala 
    50                  55                  60                  


Ser Lys Cys Arg Val Ile Asn Lys Glu His Val Leu Ala Ala Ala Lys 
65                  70                  75                  80  


Val Ile Leu Lys Lys Ser Arg Gly 
                85              


<210>  2025
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP112__Homo_sapiens__NP_001032402

<400>  2025

Met Trp Ala Ser Leu Ser Leu Asp His Pro Ser Ala Lys Glu Asn Gln 
1               5                   10                  15      


Ala Leu Arg Leu Ile Glu Met Arg Glu Glu Asn Gly Asn Val Pro Lys 
            20                  25                  30          


Thr Glu Gln Ala Gly Ser Leu Lys Pro Leu Arg Asp Thr Gly Lys Ser 
        35                  40                  45              


Asn Leu Lys Glu Lys Lys Ala Asn Ser Lys Leu Lys Gln Ile Glu Lys 
    50                  55                  60                  


Glu Tyr Thr Gln Lys Leu Ala Lys Ser Ser Gln Ile Ile Ala Glu Leu 
65                  70                  75                  80  


Gln Thr Thr Ile Ser Ser Leu Lys Glu Glu Asn Ser Gln Gln Gln Leu 
                85                  90                  95      


Ala Ala Glu Arg Arg Leu Gln Asp Val Arg Gln Lys Phe Glu Asp Glu 
            100                 105                 110         


Lys Lys Gln Leu Ile Arg Asp Asn Asp Gln Ala Ile Lys Val Leu Gln 
        115                 120                 125             


Asp Glu Leu Glu Asn Arg Ser Asn Gln Val Arg Cys Ala Glu Lys Lys 
    130                 135                 140                 


Leu Gln His Lys Glu Leu Glu Ser Gln Glu Gln Ile Thr Tyr Ile Arg 
145                 150                 155                 160 


Gln Glu Tyr Glu Thr Lys Leu Lys Gly Leu Met Pro Ala Ser Leu Arg 
                165                 170                 175     


Gln Glu Leu Glu Asp Thr Ile Ser Ser Leu Lys Ser Gln Val Asn Phe 
            180                 185                 190         


Leu Gln Lys Arg Ala Ser Ile Leu Gln Glu Glu Leu Thr Thr Tyr Gln 
        195                 200                 205             


Gly Arg Arg 
    210     


<210>  2026
<211>  960
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP120__Homo_sapiens__NP_001159698

<400>  2026

Met Leu Val Val Glu Ala Lys Phe Asp Gly Glu Gln Leu Ala Thr Asp 
1               5                   10                  15      


Pro Val Asp His Thr Asp Gln Pro Glu Phe Ala Thr Glu Leu Ala Trp 
            20                  25                  30          


Glu Ile Asp Arg Lys Ala Leu His Gln His Arg Leu Gln Arg Thr Pro 
        35                  40                  45              


Ile Lys Leu Gln Cys Phe Ala Leu Asp Pro Val Thr Ser Ala Lys Glu 
    50                  55                  60                  


Thr Ile Gly Tyr Ile Val Leu Asp Leu Arg Thr Ala Gln Glu Thr Lys 
65                  70                  75                  80  


Gln Ala Pro Lys Trp Tyr Gln Leu Leu Ser Asn Lys Tyr Thr Lys Phe 
                85                  90                  95      


Lys Ser Glu Ile Gln Ile Ser Ile Ala Leu Glu Thr Asp Thr Lys Pro 
            100                 105                 110         


Pro Val Asp Ser Phe Lys Ala Lys Gly Ala Pro Pro Arg Asp Gly Lys 
        115                 120                 125             


Val Pro Ala Ile Leu Ala Gly Leu Asp Pro Arg Asp Ile Val Ala Val 
    130                 135                 140                 


Leu Asn Glu Glu Gly Gly Tyr His Gln Ile Gly Pro Ala Glu Tyr Cys 
145                 150                 155                 160 


Thr Asp Ser Phe Ile Met Ser Val Thr Ile Ala Phe Ala Thr Gln Leu 
                165                 170                 175     


Glu Gln Leu Ile Pro Cys Thr Met Lys Leu Pro Glu Arg Gln Pro Glu 
            180                 185                 190         


Phe Phe Phe Tyr Tyr Ser Leu Leu Gly Asn Asp Val Thr Asn Glu Pro 
        195                 200                 205             


Phe Asn Asp Leu Ile Asn Pro Asn Phe Glu Pro Glu Arg Ala Ser Val 
    210                 215                 220                 


Arg Ile Arg Ser Ser Val Glu Ile Leu Arg Val Tyr Leu Ala Leu Gln 
225                 230                 235                 240 


Ser Lys Leu Gln Ile His Leu Cys Cys Gly Asp Gln Ser Leu Gly Ser 
                245                 250                 255     


Thr Glu Ile Pro Leu Thr Gly Leu Leu Lys Lys Gly Ser Thr Glu Ile 
            260                 265                 270         


Asn Gln His Pro Val Thr Val Glu Gly Ala Phe Thr Leu Asp Pro Pro 
        275                 280                 285             


Asn Arg Ala Lys Gln Lys Leu Ala Pro Ile Pro Val Glu Leu Ala Pro 
    290                 295                 300                 


Thr Val Gly Val Ser Val Ala Leu Gln Arg Glu Gly Ile Asp Ser Gln 
305                 310                 315                 320 


Ser Leu Ile Glu Leu Lys Thr Gln Asn Glu His Glu Pro Glu His Ser 
                325                 330                 335     


Lys Lys Lys Val Leu Thr Pro Ile Lys Glu Lys Thr Leu Thr Gly Pro 
            340                 345                 350         


Lys Ser Pro Thr Val Ser Pro Val Pro Ser His Asn Gln Ser Pro Pro 
        355                 360                 365             


Thr Lys Asp Asp Ala Thr Glu Ser Glu Val Glu Ser Leu Gln Tyr Asp 
    370                 375                 380                 


Lys Asp Thr Lys Pro Asn Pro Lys Ala Ser Ser Ser Val Pro Ala Ser 
385                 390                 395                 400 


Leu Ala Gln Leu Val Thr Thr Ser Asn Ala Ser Glu Val Ala Ser Gly 
                405                 410                 415     


Gln Lys Ile Ala Val Pro Ala Thr Ser His His Phe Cys Phe Ser Ile 
            420                 425                 430         


Asp Leu Arg Ser Ile His Ala Leu Glu Ile Gly Phe Pro Ile Asn Cys 
        435                 440                 445             


Ile Leu Arg Tyr Ser Tyr Pro Phe Phe Gly Ser Ala Ala Pro Ile Met 
    450                 455                 460                 


Thr Asn Pro Pro Val Glu Val Arg Lys Asn Met Glu Val Phe Leu Pro 
465                 470                 475                 480 


Gln Ser Tyr Cys Ala Phe Asp Phe Ala Thr Met Pro His Gln Leu Gln 
                485                 490                 495     


Asp Thr Phe Leu Arg Ile Pro Leu Leu Val Glu Leu Trp His Lys Asp 
            500                 505                 510         


Lys Met Ser Lys Asp Leu Leu Leu Gly Ile Ala Arg Ile Gln Leu Ser 
        515                 520                 525             


Asn Ile Leu Ser Ser Glu Lys Thr Arg Phe Leu Gly Ser Asn Gly Glu 
    530                 535                 540                 


Gln Cys Trp Arg Gln Thr Tyr Ser Glu Ser Val Pro Val Ile Ala Ala 
545                 550                 555                 560 


Gln Gly Ser Asn Asn Arg Ile Ala Asp Leu Ser Tyr Thr Val Thr Leu 
                565                 570                 575     


Glu Asp Tyr Gly Leu Val Lys Met Arg Glu Ile Phe Ile Ser Asp Ser 
            580                 585                 590         


Ser Gln Gly Val Ser Ala Val Gln Gln Lys Pro Ser Ser Leu Pro Pro 
        595                 600                 605             


Ala Pro Cys Pro Ser Glu Ile Gln Thr Glu Pro Arg Glu Thr Leu Glu 
    610                 615                 620                 


Tyr Lys Ala Ala Leu Glu Leu Glu Met Trp Lys Glu Met Gln Glu Asp 
625                 630                 635                 640 


Ile Phe Glu Asn Gln Leu Lys Gln Lys Glu Leu Ala His Met Gln Ala 
                645                 650                 655     


Leu Ala Glu Glu Trp Lys Lys Arg Asp Arg Glu Arg Glu Ser Leu Val 
            660                 665                 670         


Lys Lys Lys Val Ala Glu Tyr Thr Ile Leu Glu Gly Lys Leu Gln Lys 
        675                 680                 685             


Thr Leu Ile Asp Leu Glu Lys Arg Glu Gln Gln Leu Ala Ser Val Glu 
    690                 695                 700                 


Ser Glu Leu Gln Arg Glu Lys Lys Glu Leu Gln Ser Glu Arg Gln Arg 
705                 710                 715                 720 


Asn Leu Gln Glu Leu Gln Asp Ser Ile Arg Arg Ala Lys Glu Asp Cys 
                725                 730                 735     


Ile His Gln Val Glu Leu Glu Arg Leu Lys Ile Lys Gln Leu Glu Glu 
            740                 745                 750         


Asp Lys His Arg Leu Gln Gln Gln Leu Asn Asp Ala Glu Asn Lys Tyr 
        755                 760                 765             


Lys Ile Leu Glu Lys Glu Phe Gln Gln Phe Lys Asp Gln Gln Asn Asn 
    770                 775                 780                 


Lys Pro Glu Ile Arg Leu Gln Ser Glu Ile Asn Leu Leu Thr Leu Glu 
785                 790                 795                 800 


Lys Val Glu Leu Glu Arg Lys Leu Glu Ser Ala Thr Lys Ser Lys Leu 
                805                 810                 815     


His Tyr Lys Gln Gln Trp Gly Arg Ala Leu Lys Glu Leu Ala Arg Leu 
            820                 825                 830         


Lys Gln Arg Glu Gln Glu Ser Gln Met Ala Arg Leu Lys Lys Gln Gln 
        835                 840                 845             


Glu Glu Leu Glu Gln Met Arg Leu Arg Tyr Leu Ala Ala Glu Glu Lys 
    850                 855                 860                 


Asp Thr Val Lys Thr Glu Arg Gln Glu Leu Leu Asp Ile Arg Asn Glu 
865                 870                 875                 880 


Leu Asn Arg Leu Arg Gln Gln Glu Gln Lys Gln Tyr Gln Asp Ser Thr 
                885                 890                 895     


Glu Ile Ala Ser Gly Lys Lys Asp Gly Pro His Gly Ser Val Leu Glu 
            900                 905                 910         


Glu Gly Leu Asp Asp Tyr Leu Thr Arg Leu Ile Glu Glu Arg Asp Thr 
        915                 920                 925             


Leu Met Arg Thr Gly Val Tyr Asn His Glu Asp Arg Ile Ile Ser Glu 
    930                 935                 940                 


Leu Asp Arg Gln Ile Arg Glu Ile Leu Ala Lys Ser Asn Ala Ser Asn 
945                 950                 955                 960 


<210>  2027
<211>  1094
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP128__Homo_sapiens__XP_006720119

<400>  2027

Met Ala Glu Ser Ser Ser Glu Ser Asp His Phe Arg Cys Arg Asp Arg 
1               5                   10                  15      


Leu Ser Pro Trp Ala Ala Arg Ser Thr His Arg Gly Thr Arg Ser Leu 
            20                  25                  30          


Pro Thr Val Glu Val Thr Glu Lys Val Asn Thr Ile Thr Ser Thr Leu 
        35                  40                  45              


Gln Asp Thr Ser Arg Asn Leu Arg Gln Val Asp Gln Met Leu Gly Arg 
    50                  55                  60                  


Tyr Arg Glu Tyr Ser Asn Gly Gln Ala Gly Ala Ile Glu His Leu Lys 
65                  70                  75                  80  


Glu Ser Leu Glu Gln Ser Ile Asp Gln Leu Arg Ser Gln Arg Leu Leu 
                85                  90                  95      


Arg Asn Ser Gly Gly Arg Ser Ile Ser Val Thr Ser Leu Ser Ala Ser 
            100                 105                 110         


Asp Leu Asp Gly Gly Thr Gly Ser Glu Leu His His Phe Pro Pro Thr 
        115                 120                 125             


Ser Pro Leu Lys Asp Tyr Gly Asp Pro Gln Gly Ile Lys Arg Met Arg 
    130                 135                 140                 


Ser Arg Thr Gly Val Arg Phe Val Gln Glu Thr Asp Asp Met Thr Gln 
145                 150                 155                 160 


Leu His Gly Phe His Gln Ser Leu Arg Asp Leu Ser Ser Glu Gln Ile 
                165                 170                 175     


Arg Leu Gly Asp Asp Phe Asn Arg Glu Leu Ser Arg Arg Ser Arg Ser 
            180                 185                 190         


Asp Ala Glu Thr Lys Arg Ala Leu Glu Glu Leu Thr Glu Lys Leu Asn 
        195                 200                 205             


Glu Ala Gln Lys Gln Glu Val Val Ser Asp Arg Val Glu Arg Arg Leu 
    210                 215                 220                 


Gln Glu Leu Glu Arg Glu Met Arg Thr Glu Arg Glu Leu Val Glu Arg 
225                 230                 235                 240 


Arg Gln Asp Gln Leu Gly Leu Met Ser Leu Gln Leu Gln Glu Ala Leu 
                245                 250                 255     


Lys Lys Gln Glu Ala Lys Ala Asp Glu His Glu Gly Ala Ile Lys Asn 
            260                 265                 270         


Lys Leu Arg Gln Thr Glu Thr Glu Lys Asn Gln Leu Glu Gln Glu Leu 
        275                 280                 285             


Glu Leu Ser Arg Arg Leu Leu Asn Gln Ser Glu Gly Ser Arg Glu Thr 
    290                 295                 300                 


Leu Leu His Gln Val Glu Glu Leu Arg Thr Gln Leu Thr Lys Ala Glu 
305                 310                 315                 320 


Gly Asp Arg Lys Gly Leu Gln His Gln Val Ser Gln Ile Ser Lys Gln 
                325                 330                 335     


Gln Ser Asn Tyr Gln Asp Glu Gln Gly Glu Asp Trp Arg Phe Arg Arg 
            340                 345                 350         


Gly Val Glu Arg Glu Lys Gln Asp Leu Glu Lys Gln Met Ser Asp Leu 
        355                 360                 365             


Arg Val Gln Leu Asn Phe Ser Ala Met Ala Ser Glu Leu Glu Glu Val 
    370                 375                 380                 


Lys Arg Cys Met Glu Arg Lys Asp Lys Glu Lys Ala His Leu Ala Ser 
385                 390                 395                 400 


Gln Val Glu Asn Leu Thr Arg Glu Leu Glu Asn Gly Glu Lys Gln Gln 
                405                 410                 415     


Leu Gln Met Leu Asp Arg Leu Lys Glu Ile Gln Asn His Phe Asp Thr 
            420                 425                 430         


Cys Glu Ala Glu Arg Lys His Ala Asp Leu Gln Ile Ser Glu Leu Thr 
        435                 440                 445             


Arg His Ala Glu Asp Ala Thr Lys Gln Ala Glu Arg Tyr Leu Ser Glu 
    450                 455                 460                 


Leu Gln Gln Ser Glu Ala Leu Lys Glu Glu Ala Glu Lys Arg Arg Glu 
465                 470                 475                 480 


Asp Leu Lys Leu Lys Ala Gln Glu Ser Ile Arg Gln Trp Lys Leu Lys 
                485                 490                 495     


His Lys Lys Leu Glu Arg Ala Leu Glu Lys Gln Ser Glu Thr Val Asp 
            500                 505                 510         


Glu Leu Thr Gly Lys Asn Asn Gln Ile Leu Lys Glu Lys Asp Glu Leu 
        515                 520                 525             


Lys Thr Gln Leu Tyr Ala Ala Leu Gln Gln Ile Glu Asn Leu Arg Lys 
    530                 535                 540                 


Glu Leu Asn Asp Val Leu Thr Lys Arg Ala Leu Gln Glu Glu Glu Leu 
545                 550                 555                 560 


His Ser Lys Glu Glu Lys Leu Arg Asp Ile Lys Ser His Gln Ala Asp 
                565                 570                 575     


Leu Glu Leu Glu Val Lys Asn Ser Leu Asp Thr Ile His Arg Leu Glu 
            580                 585                 590         


Ser Glu Leu Lys Lys Gln Ser Lys Ile Gln Ser Gln Met Lys Val Glu 
        595                 600                 605             


Lys Ala His Leu Glu Glu Glu Ile Ala Glu Leu Lys Lys Ser Gln Ala 
    610                 615                 620                 


Gln Asp Lys Ala Lys Leu Leu Glu Met Gln Glu Ser Ile Lys Asp Leu 
625                 630                 635                 640 


Ser Ala Ile Arg Ala Asp Leu Ala Asn Lys Leu Ala Glu Glu Glu Arg 
                645                 650                 655     


Ala Lys Lys Ala Val Leu Lys Asp Leu Ser Asp Leu Thr Ala Gln Ala 
            660                 665                 670         


Lys Ser Arg Asp Glu Glu Thr Ala Thr Ile Ile Thr Gln Leu Lys Leu 
        675                 680                 685             


Glu Arg Asp Val His Gln Arg Glu Leu Lys Asp Leu Thr Ser Ser Leu 
    690                 695                 700                 


Gln Ser Val Lys Thr Lys His Glu Gln Asn Ile Gln Glu Leu Met Lys 
705                 710                 715                 720 


His Phe Lys Lys Glu Lys Ser Glu Ala Glu Asn His Ile Arg Thr Leu 
                725                 730                 735     


Lys Ala Glu Ser Leu Glu Glu Lys Asn Met Ala Lys Ile His Arg Gly 
            740                 745                 750         


Gln Leu Glu Lys Leu Lys Ser Gln Cys Asp Arg Leu Thr Glu Glu Leu 
        755                 760                 765             


Thr Gln Asn Glu Asn Glu Asn Lys Lys Leu Lys Leu Lys Tyr Gln Cys 
    770                 775                 780                 


Leu Lys Asp Gln Leu Glu Glu Arg Glu Lys His Ile Ser Ile Glu Glu 
785                 790                 795                 800 


Glu His Leu Arg Arg Met Glu Glu Ala Arg Leu Gln Leu Lys Asp Gln 
                805                 810                 815     


Leu Leu Cys Leu Glu Thr Glu Gln Glu Ser Ile Leu Gly Val Ile Gly 
            820                 825                 830         


Lys Glu Ile Asp Ala Ala Cys Lys Thr Phe Ser Lys Asp Ser Val Glu 
        835                 840                 845             


Lys Leu Lys Val Phe Ser Ser Gly Pro Asp Ile His Tyr Asp Pro His 
    850                 855                 860                 


Arg Trp Leu Ala Glu Ser Lys Thr Lys Leu Gln Trp Leu Cys Glu Glu 
865                 870                 875                 880 


Leu Lys Glu Arg Glu Asn Arg Glu Lys Asn Leu Arg His Gln Leu Met 
                885                 890                 895     


Leu Cys Arg Gln Gln Leu Arg Asn Leu Thr Glu Asn Lys Glu Ser Glu 
            900                 905                 910         


Leu Gln Cys Leu Phe Gln Gln Ile Glu Arg Gln Glu Gln Leu Leu Asp 
        915                 920                 925             


Glu Ile His Arg Glu Lys Arg Asp Leu Leu Glu Glu Thr Gln Arg Lys 
    930                 935                 940                 


Asp Glu Glu Met Gly Ser Leu Gln Asp Arg Val Ile Ala Leu Glu Thr 
945                 950                 955                 960 


Ser Thr Gln Val Ala Leu Asp His Leu Glu Ser Val Pro Glu Lys Leu 
                965                 970                 975     


Ser Leu Leu Glu Asp Phe Lys Asp Phe Arg Asp Ser Cys Ser Ser Ser 
            980                 985                 990         


Glu Arg Thr Asp Gly Arg Tyr Ser  Lys Tyr Arg Val Arg  Arg Asn Ser 
        995                 1000                 1005             


Leu Gln  His His Gln Asp Asp  Thr Lys Tyr Arg Thr  Lys Ser Phe 
    1010                 1015                 1020             


Lys Gly  Asp Arg Thr Phe Leu  Glu Gly Ser His Thr  Arg Gly Leu 
    1025                 1030                 1035             


Asp His  Ser Ser Ser Trp Gln  Asp His Ser Arg Phe  Leu Ser Ser 
    1040                 1045                 1050             


Pro Arg  Phe Ser Tyr Val Asn  Ser Phe Thr Lys Arg  Thr Val Ala 
    1055                 1060                 1065             


Pro Asp  Ser Ala Ser Asn Lys  Glu Asp Ala Thr Met  Asn Gly Thr 
    1070                 1075                 1080             


Ser Ser  Gln Pro Lys Lys Glu  Glu Tyr Gly Ser 
    1085                 1090                 


<210>  2028
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP131__Homo_sapiens__NP_001009811

<400>  2028

Met Lys Gly Thr Arg Ala Ile Gly Ser Val Pro Glu Arg Ser Pro Ala 
1               5                   10                  15      


Gly Val Asp Leu Ser Leu Thr Gly Leu Pro Pro Pro Val Ser Arg Arg 
            20                  25                  30          


Pro Gly Ser Ala Ala Thr Thr Lys Pro Ile Val Arg Ser Val Ser Val 
        35                  40                  45              


Val Thr Gly Ser Glu Gln Lys Arg Lys Val Leu Glu Ala Thr Gly Pro 
    50                  55                  60                  


Gly Gly Ser Gln Ala Ile Asn Asn Leu Arg Arg Ser Asn Ser Thr Thr 
65                  70                  75                  80  


Gln Val Ser Gln Pro Arg Ser Gly Ser Pro Arg Pro Thr Glu Pro Thr 
                85                  90                  95      


Asp Phe Leu Met Leu Phe Glu Gly Ser Pro Ser Gly Lys Lys Arg Pro 
            100                 105                 110         


Ala Ser Leu Ser Thr Ala Pro Ser Glu Lys Gly Ala Thr Trp Asn Val 
        115                 120                 125             


Leu Asp Asp Gln Pro Arg Gly Phe Thr Leu Pro Ser Asn Ala Arg Ser 
    130                 135                 140                 


Ser Ser Ala Leu Asp Ser Pro Ala Gly Pro Arg Arg Lys Glu Cys Thr 
145                 150                 155                 160 


Val Ala Leu Ala Pro Asn Phe Thr Ala Asn Asn Arg Ser Asn Lys Gly 
                165                 170                 175     


Ala Val Gly Asn Cys Val Thr Thr Met Val His Asn Arg Tyr Thr Pro 
            180                 185                 190         


Ser Glu Arg Ala Pro Pro Leu Lys Ser Ser Asn Gln Thr Ala Pro Ser 
        195                 200                 205             


Leu Asn Asn Ile Ile Lys Ala Ala Thr Cys Glu Gly Ser Glu Ser Ser 
    210                 215                 220                 


Gly Phe Gly Lys Leu Pro Lys Asn Val Ser Ser Ala Thr His Ser Ala 
225                 230                 235                 240 


Arg Asn Asn Thr Gly Gly Ser Thr Gly Leu Pro Arg Arg Lys Glu Val 
                245                 250                 255     


Thr Glu Glu Glu Ala Glu Arg Phe Ile His Gln Val Asn Gln Ala Thr 
            260                 265                 270         


Val Thr Ile Gln Arg Trp Tyr Arg His Gln Val Gln Arg Arg Gly Ala 
        275                 280                 285             


Gly Ala Ala Arg Leu Glu His Leu Leu Gln Ala Lys Arg Glu Glu Gln 
    290                 295                 300                 


Arg Gln Arg Ser Gly Glu Gly Thr Leu Leu Asp Leu His Gln Gln Lys 
305                 310                 315                 320 


Glu Ala Ala Arg Arg Lys Ala Arg Glu Glu Lys Ala Arg Gln Ala Arg 
                325                 330                 335     


Arg Ala Ala Ile Gln Glu Leu Gln Gln Lys Arg Ala Leu Arg Ala Gln 
            340                 345                 350         


Lys Ala Ser Thr Ala Glu Arg Gly Pro Pro Glu Asn Pro Arg Glu Thr 
        355                 360                 365             


Arg Val Pro Gly Met Arg Gln Pro Ala Gln Glu Leu Ser Pro Thr Pro 
    370                 375                 380                 


Gly Gly Thr Ala His Gln Ala Leu Lys Ala Asn Asn Thr Gly Gly Gly 
385                 390                 395                 400 


Leu Pro Ala Ala Gly Pro Gly Asp Arg Cys Leu Pro Thr Ser Asp Ser 
                405                 410                 415     


Ser Pro Glu Pro Gln Gln Pro Pro Glu Asp Arg Thr Gln Asp Val Leu 
            420                 425                 430         


Ala Gln Asp Ala Ala Gly Asp Asn Leu Glu Met Met Ala Pro Ser Arg 
        435                 440                 445             


Gly Ser Ala Lys Ser Arg Gly Pro Leu Glu Glu Leu Leu His Thr Leu 
    450                 455                 460                 


Gln Leu Leu Glu Lys Glu Pro Asp Val Leu Pro Arg Pro Arg Thr His 
465                 470                 475                 480 


His Arg Gly Arg Tyr Ala Trp Ala Ser Glu Glu Asp Asp Ala Ser Ser 
                485                 490                 495     


Leu Thr Ala Asp Asn Leu Glu Lys Phe Gly Lys Leu Ser Ala Phe Pro 
            500                 505                 510         


Glu Pro Pro Glu Asp Gly Thr Leu Leu Ser Glu Ala Lys Leu Gln Ser 
        515                 520                 525             


Ile Met Ser Phe Leu Asp Glu Met Glu Lys Ser Gly Gln Asp Gln Leu 
    530                 535                 540                 


Asp Ser Gln Gln Glu Gly Trp Val Pro Glu Ala Gly Pro Gly Pro Leu 
545                 550                 555                 560 


Glu Leu Gly Ser Glu Val Ser Thr Ser Val Met Arg Leu Lys Leu Glu 
                565                 570                 575     


Val Glu Glu Lys Lys Gln Ala Met Leu Leu Leu Gln Arg Ala Leu Ala 
            580                 585                 590         


Gln Gln Arg Asp Leu Thr Ala Arg Arg Val Lys Glu Thr Glu Lys Ala 
        595                 600                 605             


Leu Ser Arg Gln Leu Gln Arg Gln Arg Glu His Tyr Glu Ala Thr Ile 
    610                 615                 620                 


Gln Arg His Leu Ala Phe Ile Asp Gln Leu Ile Glu Asp Lys Lys Val 
625                 630                 635                 640 


Leu Ser Glu Lys Cys Glu Ala Val Val Ala Glu Leu Lys Gln Glu Asp 
                645                 650                 655     


Gln Arg Cys Thr Glu Arg Val Ala Gln Ala Gln Ala Gln His Glu Leu 
            660                 665                 670         


Glu Ile Lys Lys Leu Lys Glu Leu Met Ser Ala Thr Glu Lys Ala Arg 
        675                 680                 685             


Arg Glu Lys Trp Ile Ser Glu Lys Thr Lys Lys Ile Lys Glu Val Thr 
    690                 695                 700                 


Val Arg Gly Leu Glu Pro Glu Ile Gln Lys Leu Ile Ala Arg His Lys 
705                 710                 715                 720 


Gln Glu Val Arg Arg Leu Lys Ser Leu His Glu Ala Glu Leu Leu Gln 
                725                 730                 735     


Ser Asp Glu Arg Ala Ser Gln Arg Cys Leu Arg Gln Ala Glu Glu Leu 
            740                 745                 750         


Arg Glu Gln Leu Glu Arg Glu Lys Glu Ala Leu Gly Gln Gln Glu Arg 
        755                 760                 765             


Glu Arg Ala Arg Gln Arg Gln Arg Ala Glu Leu Glu Glu Leu Arg Gln 
    770                 775                 780                 


Gln Leu Glu Glu Ser Ser Ser Ala Leu Thr Arg Ala Leu Arg Ala Glu 
785                 790                 795                 800 


Phe Glu Lys Gly Arg Glu Glu Gln Glu Arg Arg His Gln Met Glu Leu 
                805                 810                 815     


Asn Thr Leu Lys Gln Gln Leu Glu Leu Glu Arg Gln Ala Trp Glu Ala 
            820                 825                 830         


Gly Arg Thr Arg Lys Glu Glu Ala Trp Leu Leu Asn Arg Glu Gln Glu 
        835                 840                 845             


Leu Arg Glu Glu Ile Arg Lys Gly Arg Asp Lys Glu Ile Glu Leu Val 
    850                 855                 860                 


Ile His Arg Leu Glu Ala Asp Met Ala Leu Ala Lys Glu Glu Ser Glu 
865                 870                 875                 880 


Lys Ala Ala Glu Ser Arg Ile Lys Arg Leu Arg Asp Lys Tyr Glu Ala 
                885                 890                 895     


Glu Leu Ser Glu Leu Glu Gln Ser Glu Arg Lys Leu Gln Glu Arg Cys 
            900                 905                 910         


Ser Glu Leu Lys Gly Gln Leu Gly Glu Ala Glu Gly Glu Asn Leu Arg 
        915                 920                 925             


Leu Gln Gly Leu Val Arg Gln Lys Glu Arg Ala Leu Glu Asp Ala Gln 
    930                 935                 940                 


Ala Val Asn Glu Gln Leu Ser Ser Glu Arg Ser Asn Leu Ala Gln Val 
945                 950                 955                 960 


Ile Arg Gln Glu Phe Glu Asp Arg Leu Ala Ala Ser Glu Glu Glu Thr 
                965                 970                 975     


Arg Gln Ala Lys Ala Glu Leu Ala Thr Leu Gln Ala Arg Gln Gln Leu 
            980                 985                 990         


Glu Leu Glu Glu Val His Arg Arg  Val Lys Thr Ala Leu  Ala Arg Lys 
        995                 1000                 1005             


Glu Glu  Ala Val Ser Ser Leu  Arg Thr Gln His Glu  Ala Ala Val 
    1010                 1015                 1020             


Lys Arg  Ala Asp His Leu Glu  Glu Leu Leu Glu Gln  His Arg Arg 
    1025                 1030                 1035             


Pro Thr  Pro Ser Thr Lys 
    1040                 


<210>  2029
<211>  1140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP135__Homo_sapiens__NP_079285

<400>  2029

Met Thr Thr Ala Val Glu Arg Lys Tyr Ile Asn Ile Arg Lys Arg Leu 
1               5                   10                  15      


Asp Gln Leu Gly Tyr Arg Gln Thr Leu Thr Val Glu Cys Leu Pro Leu 
            20                  25                  30          


Val Glu Lys Leu Phe Ser Asp Leu Val His Thr Thr Glu Ser Leu Arg 
        35                  40                  45              


Gln Ser Lys Leu Ser Ala Val Lys Ala Glu Lys Glu Ser Ala Asn Phe 
    50                  55                  60                  


Asp Phe Val Leu Glu Pro Tyr Lys Leu Glu Asn Ala Arg Leu Ser Arg 
65                  70                  75                  80  


Glu Asn Asn Glu Leu Tyr Leu Glu Leu Met Lys Leu Arg Glu His Ser 
                85                  90                  95      


Asp Gln His Val Lys Glu Leu Lys Thr Ser Leu Lys Lys Cys Ala Arg 
            100                 105                 110         


Glu Thr Ala Asp Leu Lys Phe Leu Asn Asn Gln Tyr Ala His Lys Leu 
        115                 120                 125             


Lys Leu Leu Glu Lys Glu Ser Lys Ala Lys Asn Glu Arg Ile Gln Gln 
    130                 135                 140                 


Leu Gln Glu Lys Asn Leu His Ala Val Val Gln Thr Pro Gly Gly Lys 
145                 150                 155                 160 


Lys Arg Ser Ile Ala Phe Arg Arg Gln Arg Met Gln Ile Asp Glu Pro 
                165                 170                 175     


Val Pro Pro Ser Glu Val Ser Ser Tyr Pro Val Pro Gln Pro Asp Asp 
            180                 185                 190         


Pro Tyr Ile Ala Asp Leu Leu Gln Val Ala Asp Asn Arg Ile Gln Glu 
        195                 200                 205             


Leu Gln Gln Glu Val His Gln Leu Gln Glu Lys Leu Ala Met Met Glu 
    210                 215                 220                 


Ser Gly Val Arg Asp Tyr Ser Lys Gln Ile Glu Leu Arg Glu Arg Glu 
225                 230                 235                 240 


Ile Glu Arg Leu Ser Val Ala Leu Asp Gly Gly Arg Ser Pro Asp Val 
                245                 250                 255     


Leu Ser Leu Glu Ser Arg Asn Lys Thr Asn Glu Lys Leu Ile Ala His 
            260                 265                 270         


Leu Asn Ile Gln Val Asp Phe Leu Gln Gln Ala Asn Lys Asp Leu Glu 
        275                 280                 285             


Lys Arg Ile Arg Glu Leu Met Glu Thr Lys Glu Thr Val Thr Ser Glu 
    290                 295                 300                 


Val Val Asn Leu Ser Asn Lys Asn Glu Lys Leu Cys Gln Glu Leu Thr 
305                 310                 315                 320 


Glu Ile Asp Gln Leu Ala Gln Gln Leu Glu Arg His Lys Glu Glu Val 
                325                 330                 335     


Leu Glu Thr Ala Asp Lys Glu Leu Gly Glu Ala Lys Lys Glu Ile Lys 
            340                 345                 350         


Arg Lys Leu Ser Glu Met Gln Asp Leu Glu Glu Thr Met Ala Lys Leu 
        355                 360                 365             


Gln Leu Glu Leu Asn Leu Cys Gln Lys Glu Lys Glu Arg Leu Ser Asp 
    370                 375                 380                 


Glu Leu Leu Val Lys Ser Asp Leu Glu Thr Val Val His Gln Leu Glu 
385                 390                 395                 400 


Gln Glu Lys Gln Arg Leu Ser Lys Lys Val Glu Ser Phe Ala Val Thr 
                405                 410                 415     


Glu Arg Gln Leu Thr Leu Glu Val Glu Arg Met Arg Leu Glu His Gly 
            420                 425                 430         


Ile Lys Arg Arg Asp Arg Ser Pro Ser Arg Leu Asp Thr Phe Leu Lys 
        435                 440                 445             


Gly Ile Glu Glu Glu Arg Asp Tyr Tyr Lys Lys Glu Leu Glu Arg Leu 
    450                 455                 460                 


Gln His Ile Ile Gln Arg Arg Ser Cys Ser Thr Ser Tyr Ser Ala Arg 
465                 470                 475                 480 


Glu Lys Ser Ser Ile Phe Arg Thr Pro Glu Lys Gly Asp Tyr Asn Ser 
                485                 490                 495     


Glu Ile His Gln Ile Thr Arg Glu Arg Asp Glu Leu Gln Arg Met Leu 
            500                 505                 510         


Glu Arg Phe Glu Lys Tyr Met Glu Asp Ile Gln Ser Asn Val Lys Leu 
        515                 520                 525             


Leu Thr Ala Glu Arg Asp Lys Leu Ser Val Leu Tyr Asn Glu Ala Gln 
    530                 535                 540                 


Glu Glu Leu Ser Ala Leu Arg Lys Glu Ser Thr Gln Thr Thr Ala Pro 
545                 550                 555                 560 


His Asn Ile Val Ser Leu Met Glu Lys Glu Lys Glu Leu Ala Leu Ser 
                565                 570                 575     


Asp Leu Arg Arg Ile Met Ala Glu Lys Glu Ala Leu Arg Glu Lys Leu 
            580                 585                 590         


Glu His Ile Glu Glu Val Ser Leu Phe Gly Lys Ser Glu Leu Glu Lys 
        595                 600                 605             


Thr Ile Glu His Leu Thr Cys Val Asn His Gln Leu Glu Ser Glu Lys 
    610                 615                 620                 


Tyr Glu Leu Lys Ser Lys Val Leu Ile Met Lys Glu Thr Ile Glu Ser 
625                 630                 635                 640 


Leu Glu Asn Lys Leu Lys Val Gln Ala Gln Lys Phe Ser His Val Ala 
                645                 650                 655     


Gly Asp Ser Ser His Gln Lys Thr Glu Val Asn Ser Leu Arg Ile Val 
            660                 665                 670         


Asn Glu Gln Leu Gln Arg Ser Val Asp Asp Tyr Gln His Arg Leu Ser 
        675                 680                 685             


Ile Lys Arg Gly Glu Leu Glu Ser Ala Gln Ala Gln Ile Lys Ile Leu 
    690                 695                 700                 


Glu Glu Lys Ile Asp Glu Leu Asn Leu Lys Met Thr Ser Gln Asp Glu 
705                 710                 715                 720 


Glu Ala His Val Met Lys Lys Thr Ile Gly Val Ile Asp Lys Glu Lys 
                725                 730                 735     


Asp Phe Leu Gln Glu Thr Val Asp Glu Lys Thr Glu Lys Ile Ala Asn 
            740                 745                 750         


Leu Gln Glu Asn Leu Ala Asn Lys Glu Lys Ala Val Ala Gln Met Lys 
        755                 760                 765             


Ile Met Ile Ser Glu Cys Glu Ser Ser Val Asn Gln Leu Lys Glu Thr 
    770                 775                 780                 


Leu Val Asn Arg Asp Arg Glu Ile Asn Ser Leu Arg Arg Gln Leu Asp 
785                 790                 795                 800 


Ala Ala His Lys Glu Leu Asp Glu Val Gly Arg Ser Arg Glu Ile Ala 
                805                 810                 815     


Phe Lys Glu Asn Arg Arg Leu Gln Asp Asp Leu Ala Thr Met Ala Arg 
            820                 825                 830         


Glu Asn Gln Glu Ile Ser Leu Glu Leu Glu Ala Ala Val Gln Glu Lys 
        835                 840                 845             


Glu Glu Met Lys Ser Arg Val His Lys Tyr Ile Thr Glu Val Ser Arg 
    850                 855                 860                 


Trp Glu Ser Leu Met Ala Ala Lys Glu Lys Glu Asn Gln Asp Leu Leu 
865                 870                 875                 880 


Asp Arg Phe Gln Met Leu His Asn Arg Ala Glu Asp Trp Glu Val Lys 
                885                 890                 895     


Ala His Gln Ala Glu Gly Glu Ser Ser Ser Val Arg Leu Glu Leu Leu 
            900                 905                 910         


Ser Ile Asp Thr Glu Arg Arg His Leu Arg Glu Arg Val Glu Leu Leu 
        915                 920                 925             


Glu Lys Glu Ile Gln Glu His Ile Asn Ala His His Ala Tyr Glu Ser 
    930                 935                 940                 


Gln Ile Ser Ser Met Ala Lys Ala Met Ser Arg Leu Glu Glu Glu Leu 
945                 950                 955                 960 


Arg His Gln Glu Asp Glu Lys Ala Thr Val Leu Asn Asp Leu Ser Ser 
                965                 970                 975     


Leu Arg Glu Leu Cys Ile Lys Leu Asp Ser Gly Lys Asp Ile Met Thr 
            980                 985                 990         


Gln Gln Leu Asn Ser Lys Asn Leu  Glu Phe Glu Arg Val  Val Val Glu 
        995                 1000                 1005             


Leu Glu  Asn Val Lys Ser Glu  Ser Asp Leu Leu Lys  Lys Gln Leu 
    1010                 1015                 1020             


Ser Asn  Glu Arg His Thr Val  Lys Asn Leu Glu Ser  Leu Leu Ala 
    1025                 1030                 1035             


Thr Asn  Arg Asp Lys Glu Phe  His Ser His Leu Thr  Ser His Glu 
    1040                 1045                 1050             


Lys Asp  Thr Glu Ile Gln Leu  Leu Lys Glu Lys Leu  Thr Leu Ser 
    1055                 1060                 1065             


Glu Ser  Lys Leu Thr Ser Gln  Ser Arg Glu Asn Thr  Met Leu Arg 
    1070                 1075                 1080             


Ala Lys  Val Ala Gln Leu Gln  Thr Asp Tyr Asp Ala  Leu Lys Arg 
    1085                 1090                 1095             


Gln Ile  Ser Thr Glu Arg Tyr  Glu Arg Glu Arg Ala  Ile Gln Glu 
    1100                 1105                 1110             


Met Arg  Arg His Gly Leu Ala  Thr Pro Pro Leu Ser  Ser Thr Leu 
    1115                 1120                 1125             


Arg Ser  Pro Ser His Ser Pro  Glu His Arg Asn Val  
    1130                 1135                 1140 


<210>  2030
<211>  1654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP152__Homo_sapiens__NP_055800

<400>  2030

Met Ser Leu Asp Phe Gly Ser Val Ala Leu Pro Val Gln Asn Glu Asp 
1               5                   10                  15      


Glu Glu Tyr Asp Glu Glu Asp Tyr Glu Arg Glu Lys Glu Leu Gln Gln 
            20                  25                  30          


Leu Leu Thr Asp Leu Pro His Asp Met Leu Asp Asp Asp Leu Ser Ser 
        35                  40                  45              


Pro Glu Leu Gln Tyr Ser Asp Cys Ser Glu Asp Gly Thr Asp Gly Gln 
    50                  55                  60                  


Pro His His Pro Glu Gln Leu Glu Met Ser Trp Asn Glu Gln Met Leu 
65                  70                  75                  80  


Pro Lys Ser Gln Ser Val Asn Gly Tyr Asn Glu Ile Gln Ser Leu Tyr 
                85                  90                  95      


Ala Gly Glu Lys Cys Gly Asn Val Trp Glu Glu Asn Arg Ser Lys Thr 
            100                 105                 110         


Glu Asp Arg His Pro Val Tyr His Pro Glu Glu Gly Gly Asp Glu Gly 
        115                 120                 125             


Gly Ser Gly Tyr Ser Pro Pro Ser Lys Cys Glu Gln Thr Asp Leu Tyr 
    130                 135                 140                 


His Leu Pro Glu Asn Phe Arg Pro Tyr Thr Asn Gly Gln Lys Gln Glu 
145                 150                 155                 160 


Phe Asn Asn Gln Ala Thr Asn Val Ile Lys Phe Ser Asp Pro Gln Trp 
                165                 170                 175     


Asn His Phe Gln Gly Pro Ser Cys Gln Gly Leu Glu Pro Tyr Asn Lys 
            180                 185                 190         


Val Thr Tyr Lys Pro Tyr Gln Ser Ser Ala Gln Asn Asn Gly Ser Pro 
        195                 200                 205             


Ala Gln Glu Ile Thr Gly Ser Asp Thr Phe Glu Gly Leu Gln Gln Gln 
    210                 215                 220                 


Phe Leu Gly Ala Asn Glu Asn Ser Ala Glu Asn Met Gln Ile Ile Gln 
225                 230                 235                 240 


Leu Gln Val Leu Asn Lys Ala Lys Glu Arg Gln Leu Glu Asn Leu Ile 
                245                 250                 255     


Glu Lys Leu Asn Glu Ser Glu Arg Gln Ile Arg Tyr Leu Asn His Gln 
            260                 265                 270         


Leu Val Ile Ile Lys Asp Glu Lys Asp Gly Leu Thr Leu Ser Leu Arg 
        275                 280                 285             


Glu Ser Gln Lys Leu Phe Gln Asn Gly Lys Glu Arg Glu Ile Gln Leu 
    290                 295                 300                 


Glu Ala Gln Ile Lys Ala Leu Glu Thr Gln Ile Gln Ala Leu Lys Val 
305                 310                 315                 320 


Asn Glu Glu Gln Met Ile Lys Lys Ser Arg Thr Thr Glu Met Ala Leu 
                325                 330                 335     


Glu Ser Leu Lys Gln Gln Leu Val Asp Leu His His Ser Glu Ser Leu 
            340                 345                 350         


Gln Arg Ala Arg Glu Gln His Glu Ser Ile Val Met Gly Leu Thr Lys 
        355                 360                 365             


Lys Tyr Glu Glu Gln Val Leu Ser Leu Gln Lys Asn Leu Asp Ala Thr 
    370                 375                 380                 


Val Thr Ala Leu Lys Glu Gln Glu Asp Ile Cys Ser Arg Leu Lys Asp 
385                 390                 395                 400 


His Val Lys Gln Leu Glu Arg Asn Gln Glu Ala Ile Lys Leu Glu Lys 
                405                 410                 415     


Thr Glu Ile Ile Asn Lys Leu Thr Arg Ser Leu Glu Glu Ser Gln Lys 
            420                 425                 430         


Gln Cys Ala His Leu Leu Gln Ser Gly Ser Val Gln Glu Val Ala Gln 
        435                 440                 445             


Leu Gln Phe Gln Leu Gln Gln Ala Gln Lys Ala His Ala Met Ser Ala 
    450                 455                 460                 


Asn Met Asn Lys Ala Leu Gln Glu Glu Leu Thr Glu Leu Lys Asp Glu 
465                 470                 475                 480 


Ile Ser Leu Tyr Glu Ser Ala Ala Lys Leu Gly Ile His Pro Ser Asp 
                485                 490                 495     


Ser Glu Gly Glu Leu Asn Ile Glu Leu Thr Glu Ser Tyr Val Asp Leu 
            500                 505                 510         


Gly Ile Lys Lys Val Asn Trp Lys Lys Ser Lys Val Thr Ser Ile Val 
        515                 520                 525             


Gln Glu Glu Asp Pro Asn Glu Glu Leu Ser Lys Asp Glu Phe Ile Leu 
    530                 535                 540                 


Lys Leu Lys Ala Glu Val Gln Arg Leu Leu Gly Ser Asn Ser Met Lys 
545                 550                 555                 560 


Arg His Leu Val Ser Gln Leu Gln Asn Asp Leu Lys Asp Cys His Lys 
                565                 570                 575     


Lys Ile Glu Asp Leu His Gln Val Lys Lys Asp Glu Lys Ser Ile Glu 
            580                 585                 590         


Val Glu Thr Lys Thr Asp Thr Ser Glu Lys Pro Lys Asn Gln Leu Trp 
        595                 600                 605             


Pro Glu Ser Ser Thr Ser Asp Val Val Arg Asp Asp Ile Leu Leu Leu 
    610                 615                 620                 


Lys Asn Glu Ile Gln Val Leu Gln Gln Gln Asn Gln Glu Leu Lys Glu 
625                 630                 635                 640 


Thr Glu Gly Lys Leu Arg Asn Thr Asn Gln Asp Leu Cys Asn Gln Met 
                645                 650                 655     


Arg Gln Met Val Gln Asp Phe Asp His Asp Lys Gln Glu Ala Val Asp 
            660                 665                 670         


Arg Cys Glu Arg Thr Tyr Gln Gln His His Glu Ala Met Lys Thr Gln 
        675                 680                 685             


Ile Arg Glu Ser Leu Leu Ala Lys His Ala Leu Glu Lys Gln Gln Leu 
    690                 695                 700                 


Phe Glu Ala Tyr Glu Arg Thr His Leu Gln Leu Arg Ser Glu Leu Asp 
705                 710                 715                 720 


Lys Leu Asn Lys Glu Val Thr Ala Val Gln Glu Cys Tyr Leu Glu Val 
                725                 730                 735     


Cys Arg Glu Lys Asp Asn Leu Glu Leu Thr Leu Arg Lys Thr Thr Glu 
            740                 745                 750         


Lys Glu Gln Gln Thr Gln Glu Lys Ile Lys Glu Lys Leu Ile Gln Gln 
        755                 760                 765             


Leu Glu Lys Glu Trp Gln Ser Lys Leu Asp Gln Thr Ile Lys Ala Met 
    770                 775                 780                 


Lys Lys Lys Thr Leu Asp Cys Gly Ser Gln Thr Asp Gln Val Thr Thr 
785                 790                 795                 800 


Ser Asp Val Ile Ser Lys Lys Glu Met Ala Ile Met Ile Glu Glu Gln 
                805                 810                 815     


Lys Cys Thr Ile Gln Gln Asn Leu Glu Gln Glu Lys Asp Ile Ala Ile 
            820                 825                 830         


Lys Gly Ala Met Lys Lys Leu Glu Ile Glu Leu Glu Leu Lys His Cys 
        835                 840                 845             


Glu Asn Ile Thr Lys Gln Val Glu Ile Ala Val Gln Asn Ala His Gln 
    850                 855                 860                 


Arg Trp Leu Gly Glu Leu Pro Glu Leu Ala Glu Tyr Gln Ala Leu Val 
865                 870                 875                 880 


Lys Ala Glu Gln Lys Lys Trp Glu Glu Gln His Glu Val Ser Val Asn 
                885                 890                 895     


Lys Arg Ile Ser Phe Ala Val Ser Glu Ala Lys Glu Lys Trp Lys Ser 
            900                 905                 910         


Glu Leu Glu Asn Met Arg Lys Asn Ile Leu Pro Gly Lys Glu Leu Glu 
        915                 920                 925             


Glu Lys Ile His Ser Leu Gln Lys Glu Leu Glu Leu Lys Asn Glu Glu 
    930                 935                 940                 


Val Pro Val Val Ile Arg Ala Glu Leu Ala Lys Ala Arg Ser Glu Trp 
945                 950                 955                 960 


Asn Lys Glu Lys Gln Glu Glu Ile His Arg Ile Gln Glu Gln Asn Glu 
                965                 970                 975     


Gln Asp Tyr Arg Gln Phe Leu Asp Asp His Arg Asn Lys Ile Asn Glu 
            980                 985                 990         


Val Leu Ala Ala Ala Lys Glu Asp  Phe Met Lys Gln Lys  Thr Glu Leu 
        995                 1000                 1005             


Leu Leu  Gln Lys Glu Thr Glu  Leu Gln Thr Cys Leu  Asp Gln Ser 
    1010                 1015                 1020             


Arg Arg  Glu Trp Thr Met Gln  Glu Ala Lys Arg Ile  Gln Leu Glu 
    1025                 1030                 1035             


Ile Tyr  Gln Tyr Glu Glu Asp  Ile Leu Thr Val Leu  Gly Val Leu 
    1040                 1045                 1050             


Leu Ser  Asp Thr Gln Lys Glu  His Ile Ser Asp Ser  Glu Asp Lys 
    1055                 1060                 1065             


Gln Leu  Leu Glu Ile Met Ser  Thr Cys Ser Ser Lys  Trp Met Ser 
    1070                 1075                 1080             


Val Gln  Tyr Phe Glu Lys Leu  Lys Gly Cys Ile Gln  Lys Ala Phe 
    1085                 1090                 1095             


Gln Asp  Thr Leu Pro Leu Leu  Val Glu Asn Ala Asp  Pro Glu Trp 
    1100                 1105                 1110             


Lys Lys  Arg Asn Met Ala Glu  Leu Ser Lys Asp Ser  Ala Ser Gln 
    1115                 1120                 1125             


Gly Thr  Gly Gln Gly Asp Pro  Gly Pro Ala Ala Gly  His His Ala 
    1130                 1135                 1140             


Gln Pro  Leu Ala Leu Gln Ala  Thr Glu Ala Glu Ala  Glu Glu Asn 
    1145                 1150                 1155             


Asn Lys  Val Val Glu Glu Leu  Ile Glu Glu Asn Asn  Asp Met Lys 
    1160                 1165                 1170             


Asn Lys  Leu Glu Glu Leu Gln  Thr Leu Cys Lys Thr  Pro Pro Arg 
    1175                 1180                 1185             


Ser Leu  Ser Ala Gly Ala Ile  Glu Asn Ala Cys Leu  Pro Cys Ser 
    1190                 1195                 1200             


Gly Gly  Ala Leu Glu Glu Leu  Arg Gly Gln Tyr Ile  Lys Ala Val 
    1205                 1210                 1215             


Lys Lys  Ile Lys Cys Asp Met  Leu Arg Tyr Ile Gln  Glu Ser Lys 
    1220                 1225                 1230             


Glu Arg  Ala Ala Glu Met Val  Lys Ala Glu Val Leu  Arg Glu Arg 
    1235                 1240                 1245             


Gln Glu  Thr Ala Arg Lys Met  Arg Lys Tyr Tyr Leu  Ile Cys Leu 
    1250                 1255                 1260             


Gln Gln  Ile Leu Gln Asp Asp  Gly Lys Glu Gly Ala  Glu Lys Lys 
    1265                 1270                 1275             


Ile Met  Asn Ala Ala Ser Lys  Leu Ala Thr Met Ala  Lys Leu Leu 
    1280                 1285                 1290             


Glu Thr  Pro Ile Ser Ser Lys  Ser Gln Ser Lys Thr  Thr Gln Ser 
    1295                 1300                 1305             


Ala Leu  Pro Leu Thr Ser Glu  Met Leu Ile Ala Val  Lys Lys Ser 
    1310                 1315                 1320             


Lys Arg  Asn Asp Val Asn Gln  Lys Ile Pro Cys Cys  Ile Glu Ser 
    1325                 1330                 1335             


Lys Ser  Asn Ser Val Asn Thr  Ile Thr Arg Thr Leu  Cys Glu Gln 
    1340                 1345                 1350             


Ala Pro  Lys Arg Arg Ala Ala  Cys Asn Leu Gln Arg  Leu Leu Glu 
    1355                 1360                 1365             


Asn Ser  Glu His Gln Ser Ile  Lys His Val Gly Ser  Lys Glu Thr 
    1370                 1375                 1380             


His Leu  Glu Phe Gln Phe Gly  Asp Gly Ser Cys Lys  His Leu Asn 
    1385                 1390                 1395             


Ser Leu  Pro Arg Asn Val Ser  Pro Glu Phe Val Pro  Cys Glu Gly 
    1400                 1405                 1410             


Glu Gly  Gly Phe Gly Leu His  Lys Lys Lys Asp Leu  Leu Ser Asp 
    1415                 1420                 1425             


Asn Gly  Ser Glu Ser Leu Pro  His Ser Ala Ala Tyr  Pro Phe Leu 
    1430                 1435                 1440             


Gly Thr  Leu Gly Asn Lys Pro  Ser Pro Arg Cys Thr  Pro Gly Pro 
    1445                 1450                 1455             


Ser Glu  Ser Gly Cys Met His  Ile Thr Phe Arg Asp  Ser Asn Glu 
    1460                 1465                 1470             


Arg Leu  Gly Leu Lys Val Tyr  Lys Cys Asn Pro Leu  Met Glu Ser 
    1475                 1480                 1485             


Glu Asn  Ala Ala Ser Glu Lys  Ser Gln Gly Leu Asp  Val Gln Glu 
    1490                 1495                 1500             


Pro Pro  Val Lys Asp Gly Gly  Asp Leu Ser Asp Cys  Leu Gly Trp 
    1505                 1510                 1515             


Pro Ser  Ser Ser Ala Thr Leu  Ser Phe Asp Ser Arg  Glu Ala Ser 
    1520                 1525                 1530             


Phe Val  His Gly Arg Pro Gln  Gly Thr Leu Glu Ile  Pro Ser Glu 
    1535                 1540                 1545             


Ser Val  Lys Ser Lys Gln Phe  Ser Pro Ser Gly Tyr  Leu Ser Asp 
    1550                 1555                 1560             


Thr Glu  Glu Ser Asn Met Ile  Cys Gln Thr Met Lys  Cys Gln Arg 
    1565                 1570                 1575             


Tyr Gln  Thr Pro Tyr Leu Ser  Glu Glu Thr Thr Tyr  Leu Glu Pro 
    1580                 1585                 1590             


Gly Lys  Ile Ser Val Asn Cys  Gly His Pro Ser Arg  His Lys Ala 
    1595                 1600                 1605             


Asp Arg  Leu Lys Ser Asp Phe  Lys Lys Leu Ser Ser  Thr Leu Pro 
    1610                 1615                 1620             


Ser Ser  Val Cys Gln Gln Pro  Ser Arg Lys Leu Ile  Val Pro Leu 
    1625                 1630                 1635             


Ser Ser  Gln Gln Asp Ser Gly  Phe Asp Ser Pro Phe  Val Asn Leu 
    1640                 1645                 1650             


Asp 
    


<210>  2031
<211>  1403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP162__Homo_sapiens__NP_055710

<400>  2031

Met Ala Asn Cys Ser Gln Glu Glu Leu Asp Glu Glu Phe Glu Gln Phe 
1               5                   10                  15      


Met Lys Glu Leu Ser Asp Asp Ser Phe Glu Asn Ser Asp Lys Thr Ala 
            20                  25                  30          


Arg Gln Ser Lys Lys Glu Met Lys Lys Lys Asp Thr Val Pro Trp Trp 
        35                  40                  45              


Ile Thr Glu Asp Asp Phe Lys Asp Asp Gly Leu Leu Gly Thr Asn Val 
    50                  55                  60                  


Ser Tyr Leu Lys Thr Lys Lys Thr Ser Gln Pro Val Met Glu Ile Glu 
65                  70                  75                  80  


Glu Glu Ser Ala Glu Lys Ile Gln Phe Leu Lys Ser Ser Gly Thr Ser 
                85                  90                  95      


Leu Leu Ser Thr Asp Ser Leu Glu Thr Asn Glu Leu Val Val Ser Glu 
            100                 105                 110         


Leu Asn His Ser Ser Leu Gly Val Gly Leu Asp Thr Leu Glu Glu Gln 
        115                 120                 125             


Glu Glu Lys Glu Gln Phe Phe Ala Arg Leu Glu Lys Gly Leu Thr Ser 
    130                 135                 140                 


Ser Ile Asp Tyr Ser Arg Leu Asn Lys Glu Leu Asp Ser Asn Asp Ser 
145                 150                 155                 160 


Thr His Phe Lys Ala Leu His Ser Asn Gln Ala Asn Ala Glu Leu Thr 
                165                 170                 175     


Asp Asp Glu His Glu Asn Glu Ser Lys His Glu Glu Leu Ala Glu Asn 
            180                 185                 190         


Tyr Ser Asp Asp Phe Glu Asp Glu Tyr Val Gly Ala Pro Leu Thr Thr 
        195                 200                 205             


Lys Asp Glu Glu Met Pro Ser Lys Glu Asn Ser Lys Ser Glu Lys Ile 
    210                 215                 220                 


Ser Val Pro Lys Gln Glu Glu Glu Lys Thr Gly Met Leu Ala Asn Val 
225                 230                 235                 240 


Val Leu Leu Asp Ser Leu Asp Ser Val Ala Glu Val Asn Leu Asp Glu 
                245                 250                 255     


Gln Asp Lys Ile Thr Pro Lys Pro Arg Cys Leu Pro Glu Met Thr Glu 
            260                 265                 270         


Asn Glu Met Thr Gly Thr Gly Val Ser Tyr Gly Gln Ser Ser Ser Asp 
        275                 280                 285             


Val Glu Ala Leu His Gln Ala Tyr Cys His Ile Ala His Ser Leu Gly 
    290                 295                 300                 


Asp Glu Asp Lys Gln Lys Ile Glu Ser Asn Thr Val Glu Asp Ile Lys 
305                 310                 315                 320 


Ser Ser Val Lys Gly His Pro Gln Glu Asn Glu Glu Asn Ser Lys Asn 
                325                 330                 335     


Ile Ser Thr Met Glu Ser Asp Leu Pro Thr Val Glu Glu Leu Met Lys 
            340                 345                 350         


Pro Ile Arg Ile Asp Ser Phe Gly Ile Ser Gly Phe Asp Leu Gln Pro 
        355                 360                 365             


Val Ser Ser Glu Lys Val Ala Glu Arg Lys Glu Thr Glu Phe Phe Ser 
    370                 375                 380                 


Ser Leu Pro Leu Lys Met Asn Pro Asn Ile Leu Ser Gln Asp Ser Gln 
385                 390                 395                 400 


His Val Asn Leu Phe Phe Asp Lys Asn Asp Glu Asn Val Ile Leu Gln 
                405                 410                 415     


Lys Thr Thr Asn Glu Ser Met Glu Asn Ser Cys Pro Gln Val Thr Glu 
            420                 425                 430         


Val Thr Ala Thr Glu Glu His Val Asp Lys Met Tyr Leu Asn Ile Leu 
        435                 440                 445             


Arg Lys Lys Ile Thr Val Asn Ser Ser Ser Leu Ser Gln Asp Asp Lys 
    450                 455                 460                 


Ile Asn Lys Thr Tyr Arg Ser Gln Leu Ser Ser Glu Glu Glu Gly Ala 
465                 470                 475                 480 


Val Met Gly Lys Gln Val Pro Tyr Lys Lys Ala Arg Ser Ala Pro Pro 
                485                 490                 495     


Leu Leu Lys Arg Lys Pro Gln Ser Gly Leu Tyr Ala Ser Val Arg Ser 
            500                 505                 510         


Ser Gly Tyr Gly Lys Pro Ser Ser Pro Leu Lys Met Phe Ser Thr Leu 
        515                 520                 525             


Glu Lys Lys Thr Ser Glu Asp Ile Ile Lys Ser Lys Asn Leu Arg Ser 
    530                 535                 540                 


Ile Ser Thr Ser Asn Gln Pro Arg Lys Lys Glu Ile Leu Ser Gly Thr 
545                 550                 555                 560 


Lys Leu Ile Lys Pro Ala Ala Leu Asp Lys Pro Ala His Lys Thr Glu 
                565                 570                 575     


Ser Cys Leu Ser Thr Arg Lys Lys Ser Glu Asn Pro Thr Glu Thr Asp 
            580                 585                 590         


Ser Cys Ile Gln Phe Gln Thr Asp Ser Leu Gly Tyr Cys Gly Glu Asn 
        595                 600                 605             


Lys Glu Lys Lys Leu Leu Met Phe Lys Arg Val Gln Glu Ala Glu Asp 
    610                 615                 620                 


Lys Trp Arg Gly Ala Gln Ala Leu Ile Glu Gln Ile Lys Ala Thr Phe 
625                 630                 635                 640 


Ser Glu Lys Glu Lys Glu Leu Glu Asn Lys Leu Glu Glu Leu Lys Lys 
                645                 650                 655     


Gln Gln Glu Lys Glu Leu Phe Lys Leu Asn Gln Asp Asn Tyr Ile Leu 
            660                 665                 670         


Gln Ala Lys Leu Ser Ser Phe Glu Glu Thr Asn Lys Lys Gln Arg Trp 
        675                 680                 685             


Leu His Phe Gly Glu Ala Ala Asp Pro Val Thr Gly Glu Lys Leu Lys 
    690                 695                 700                 


Gln Ile Gln Lys Glu Ile Gln Glu Gln Glu Thr Leu Leu Gln Gly Tyr 
705                 710                 715                 720 


Gln Gln Glu Asn Glu Arg Leu Tyr Asn Gln Val Lys Asp Leu Gln Glu 
                725                 730                 735     


Gln Asn Lys Lys Asn Glu Glu Arg Met Phe Lys Glu Asn Gln Ser Leu 
            740                 745                 750         


Phe Ser Glu Val Ala Ser Leu Lys Glu Gln Met His Lys Ser Arg Phe 
        755                 760                 765             


Leu Ser Gln Val Val Glu Asp Ser Glu Pro Thr Arg Asn Gln Asn Phe 
    770                 775                 780                 


Thr Asp Leu Leu Ala Glu Leu Arg Met Ala Gln Lys Glu Lys Asp Ser 
785                 790                 795                 800 


Leu Leu Glu Asp Ile Lys Arg Leu Lys Gln Asp Lys Gln Ala Leu Glu 
                805                 810                 815     


Val Asp Phe Glu Lys Met Lys Lys Glu Arg Asp Gln Ala Lys Asp Gln 
            820                 825                 830         


Ile Ala Tyr Val Thr Gly Glu Lys Leu Tyr Glu Ile Lys Ile Leu Glu 
        835                 840                 845             


Glu Thr His Lys Gln Glu Ile Ser Arg Leu Gln Lys Arg Leu Gln Trp 
    850                 855                 860                 


Tyr Ala Glu Asn Gln Glu Leu Leu Asp Lys Asp Ala Leu Arg Leu Arg 
865                 870                 875                 880 


Glu Ala Asn Glu Glu Ile Glu Lys Leu Lys Leu Glu Ile Glu Lys Leu 
                885                 890                 895     


Lys Ala Glu Ser Gly Asn Pro Ser Ile Arg Gln Lys Ile Arg Leu Lys 
            900                 905                 910         


Asp Lys Ala Ala Asp Ala Lys Lys Ile Gln Asp Leu Glu Arg Gln Val 
        915                 920                 925             


Lys Glu Met Glu Gly Ile Leu Lys Arg Arg Tyr Pro Asn Ser Leu Pro 
    930                 935                 940                 


Ala Leu Ile Leu Ala Ala Ser Ala Ala Gly Asp Thr Val Asp Lys Asn 
945                 950                 955                 960 


Thr Val Glu Phe Met Glu Lys Arg Ile Lys Lys Leu Glu Ala Asp Leu 
                965                 970                 975     


Glu Gly Lys Asp Glu Asp Ala Lys Lys Ser Leu Arg Thr Met Glu Gln 
            980                 985                 990         


Gln Phe Gln Lys Met Lys Ile Gln  Tyr Glu Gln Arg Leu  Glu Gln Gln 
        995                 1000                 1005             


Glu Gln  Leu Leu Ala Cys Lys  Leu Asn Gln His Asp  Ser Pro Arg 
    1010                 1015                 1020             


Ile Lys  Ala Leu Glu Lys Glu  Leu Asp Asp Ile Lys  Glu Ala His 
    1025                 1030                 1035             


Gln Ile  Thr Val Arg Asn Leu  Glu Ala Glu Ile Asp  Val Leu Lys 
    1040                 1045                 1050             


His Gln  Asn Ala Glu Leu Asp  Val Lys Lys Asn Asp  Lys Asp Asp 
    1055                 1060                 1065             


Glu Asp  Phe Gln Ser Ile Glu  Phe Gln Val Glu Gln  Ala His Ala 
    1070                 1075                 1080             


Lys Ala  Lys Leu Val Arg Leu  Asn Glu Glu Leu Ala  Ala Lys Lys 
    1085                 1090                 1095             


Arg Glu  Ile Gln Asp Leu Ser  Lys Thr Val Glu Arg  Leu Gln Lys 
    1100                 1105                 1110             


Asp Arg  Arg Met Met Leu Ser  Asn Gln Asn Ser Lys  Gly Arg Glu 
    1115                 1120                 1125             


Glu Met  Ser Ala Lys Arg Ala  Lys Lys Asp Val Leu  His Ser Ser 
    1130                 1135                 1140             


Lys Gly  Asn Ala Asn Ser Phe  Pro Gly Thr Leu Asp  Ser Lys Leu 
    1145                 1150                 1155             


Tyr Gln  Pro His Thr Phe Thr  Asp Ser His Val Ser  Glu Val Leu 
    1160                 1165                 1170             


Gln Glu  Asn Tyr Arg Leu Lys  Asn Glu Leu Glu Gly  Leu Ile Ser 
    1175                 1180                 1185             


Glu Lys  Asn Glu Leu Lys Met  Lys Ser Glu Ala Val  Met Asn Gln 
    1190                 1195                 1200             


Phe Glu  Asn Ser Met Arg Arg  Val Lys Glu Asp Thr  Ala Ala His 
    1205                 1210                 1215             


Ile Ala  Ser Leu Lys Ala Ser  His Gln Arg Glu Ile  Glu Lys Leu 
    1220                 1225                 1230             


Leu Cys  Gln Asn Ala Val Glu  Asn Ser Ser Ser Lys  Val Ala Glu 
    1235                 1240                 1245             


Leu Asn  Arg Lys Ile Ala Thr  Gln Glu Val Leu Ile  Arg His Phe 
    1250                 1255                 1260             


Gln Ser  Gln Val Asn Glu Leu  Gln Ser Lys Gln Glu  Ser Leu Val 
    1265                 1270                 1275             


Val Ser  Glu Val Arg Glu Glu  Ile Leu Gln Lys Glu  Ile Thr Lys 
    1280                 1285                 1290             


Leu Leu  Glu Glu Leu Arg Glu  Ala Lys Glu Asn His  Thr Pro Glu 
    1295                 1300                 1305             


Met Lys  His Phe Val Gly Leu  Glu Lys Lys Ile Lys  Gln Met Glu 
    1310                 1315                 1320             


Met Arg  His Ala Gln Arg Glu  Gln Glu Leu Gln Gln  Ile Ile Gln 
    1325                 1330                 1335             


Gln Thr  His Gln Val Val Glu  Thr Glu Gln Asn Lys  Glu Val Glu 
    1340                 1345                 1350             


Lys Trp  Lys Arg Leu Ala Gln  Leu Lys Asn Arg Glu  Leu Glu Lys 
    1355                 1360                 1365             


Phe Arg  Thr Glu Leu Asp Ser  Ile Leu Asp Val Leu  Arg Glu Leu 
    1370                 1375                 1380             


His Arg  Gln Gly Val Val Val  Pro Val Ala Phe Ala  Asp Glu Met 
    1385                 1390                 1395             


Asn Ala  Pro Glu Tyr 
    1400             


<210>  2032
<211>  1455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP164__Homo_sapiens__NP_001258862

<400>  2032

Met Ala Gly Arg Pro Leu Arg Ile Gly Asp Gln Leu Val Leu Glu Glu 
1               5                   10                  15      


Asp Tyr Asp Glu Thr Tyr Ile Pro Ser Glu Gln Glu Ile Leu Glu Phe 
            20                  25                  30          


Ala Arg Glu Ile Gly Ile Asp Pro Ile Lys Glu Pro Glu Leu Met Trp 
        35                  40                  45              


Leu Ala Arg Glu Gly Ile Val Ala Pro Leu Pro Gly Glu Trp Lys Pro 
    50                  55                  60                  


Cys Gln Asp Ile Thr Gly Asp Ile Tyr Tyr Phe Asn Phe Ala Asn Gly 
65                  70                  75                  80  


Gln Ser Met Trp Asp His Pro Cys Asp Glu His Tyr Arg Ser Leu Val 
                85                  90                  95      


Ile Gln Glu Arg Ala Lys Leu Ser Thr Ser Gly Ala Ile Lys Lys Lys 
            100                 105                 110         


Lys Lys Lys Lys Glu Lys Lys Asp Lys Lys Asp Arg Asp Pro Pro Lys 
        115                 120                 125             


Ser Ser Leu Ala Leu Gly Ser Ser Leu Ala Pro Val His Val Pro Leu 
    130                 135                 140                 


Gly Gly Leu Ala Pro Leu Arg Gly Leu Val Asp Thr Pro Pro Ser Ala 
145                 150                 155                 160 


Leu Arg Gly Ser Gln Ser Val Ser Leu Gly Ser Ser Val Glu Ser Gly 
                165                 170                 175     


Arg Gln Leu Gly Glu Leu Met Leu Pro Ser Gln Gly Leu Lys Thr Ser 
            180                 185                 190         


Ala Tyr Thr Lys Gly Leu Leu Gly Ser Ile Tyr Glu Asp Lys Thr Ala 
        195                 200                 205             


Leu Ser Leu Leu Gly Leu Gly Glu Glu Thr Asn Glu Glu Asp Glu Glu 
    210                 215                 220                 


Glu Ser Asp Asn Gln Ser Val His Ser Ser Ser Glu Pro Leu Arg Asn 
225                 230                 235                 240 


Leu His Leu Asp Ile Gly Ala Leu Gly Gly Asp Phe Glu Tyr Glu Glu 
                245                 250                 255     


Ser Leu Arg Thr Ser Gln Pro Glu Glu Lys Lys Asp Val Ser Leu Asp 
            260                 265                 270         


Ser Asp Ala Ala Gly Pro Pro Thr Pro Cys Lys Pro Ser Ser Pro Gly 
        275                 280                 285             


Ala Asp Ser Ser Leu Ser Ser Ala Val Gly Lys Gly Arg Gln Gly Ser 
    290                 295                 300                 


Gly Ala Arg Pro Gly Leu Pro Glu Lys Glu Glu Asn Glu Lys Ser Glu 
305                 310                 315                 320 


Pro Lys Ile Cys Arg Asn Leu Val Thr Pro Lys Ala Asp Pro Thr Gly 
                325                 330                 335     


Ser Glu Pro Ala Lys Ala Ser Glu Lys Glu Ala Pro Glu Asp Thr Val 
            340                 345                 350         


Asp Ala Gly Glu Glu Gly Ser Arg Arg Glu Glu Ala Ala Lys Glu Pro 
        355                 360                 365             


Lys Lys Lys Ala Ser Ala Leu Glu Glu Gly Ser Ser Asp Ala Ser Gln 
    370                 375                 380                 


Glu Leu Glu Ile Ser Glu His Met Lys Glu Pro Gln Leu Ser Asp Ser 
385                 390                 395                 400 


Ile Ala Ser Asp Pro Lys Ser Phe His Gly Leu Asp Phe Gly Phe Arg 
                405                 410                 415     


Ser Arg Ile Ser Glu His Leu Leu Asp Val Asp Val Leu Ser Pro Val 
            420                 425                 430         


Leu Gly Gly Ala Cys Arg Gln Ala Gln Gln Pro Leu Gly Ile Glu Asp 
        435                 440                 445             


Lys Asp Asp Ser Gln Ser Ser Gln Asp Glu Leu Gln Ser Lys Gln Ser 
    450                 455                 460                 


Lys Gly Leu Glu Glu Arg Tyr His Arg Leu Ser Pro Pro Leu Pro His 
465                 470                 475                 480 


Glu Glu Arg Ala Gln Ser Pro Pro Arg Ser Leu Ala Thr Glu Glu Glu 
                485                 490                 495     


Pro Pro Gln Gly Pro Glu Gly Gln Pro Glu Trp Lys Glu Ala Glu Glu 
            500                 505                 510         


Leu Gly Glu Asp Ser Ala Ala Ser Leu Ser Leu Gln Leu Ser Leu Gln 
        515                 520                 525             


Arg Glu Gln Ala Pro Ser Pro Pro Ala Ala Cys Glu Lys Gly Lys Glu 
    530                 535                 540                 


Gln His Ser Gln Ala Glu Glu Leu Gly Pro Gly Gln Glu Glu Ala Glu 
545                 550                 555                 560 


Asp Pro Glu Glu Lys Val Ala Val Ser Pro Thr Pro Pro Val Ser Pro 
                565                 570                 575     


Glu Val Arg Ser Thr Glu Pro Val Ala Pro Pro Glu Gln Leu Ser Glu 
            580                 585                 590         


Ala Ala Leu Lys Ala Met Glu Glu Ala Val Ala Gln Val Leu Glu Gln 
        595                 600                 605             


Asp Gln Arg His Leu Leu Glu Ser Lys Gln Glu Lys Met Gln Gln Leu 
    610                 615                 620                 


Arg Glu Lys Leu Cys Gln Glu Glu Glu Glu Glu Ile Leu Arg Leu His 
625                 630                 635                 640 


Gln Gln Lys Glu Gln Ser Leu Ser Ser Leu Arg Glu Arg Leu Gln Lys 
                645                 650                 655     


Ala Ile Glu Glu Glu Glu Ala Arg Met Arg Glu Glu Glu Ser Gln Arg 
            660                 665                 670         


Leu Ser Trp Leu Arg Ala Gln Val Gln Ser Ser Thr Gln Ala Asp Glu 
        675                 680                 685             


Asp Gln Ile Arg Ala Glu Gln Glu Ala Ser Leu Gln Lys Leu Arg Glu 
    690                 695                 700                 


Glu Leu Glu Ser Gln Gln Lys Ala Glu Arg Ala Ser Leu Glu Gln Lys 
705                 710                 715                 720 


Asn Arg Gln Met Leu Glu Gln Leu Lys Glu Glu Ile Glu Ala Ser Glu 
                725                 730                 735     


Lys Ser Glu Gln Ala Ala Leu Asn Ala Ala Lys Glu Lys Ala Leu Gln 
            740                 745                 750         


Gln Leu Arg Glu Gln Leu Glu Gly Glu Arg Lys Glu Ala Val Ala Thr 
        755                 760                 765             


Leu Glu Lys Glu His Ser Ala Glu Leu Glu Arg Leu Cys Ser Ser Leu 
    770                 775                 780                 


Glu Ala Lys His Arg Glu Val Val Ser Ser Leu Gln Lys Lys Ile Gln 
785                 790                 795                 800 


Glu Ala Gln Gln Lys Glu Glu Ala Gln Leu Gln Lys Cys Leu Gly Gln 
                805                 810                 815     


Val Glu His Arg Val His Gln Lys Ser Tyr His Val Ala Gly Tyr Glu 
            820                 825                 830         


His Glu Leu Ser Ser Leu Leu Arg Glu Lys Arg Gln Glu Val Glu Gly 
        835                 840                 845             


Glu His Glu Arg Arg Leu Asp Lys Met Lys Glu Glu His Gln Gln Val 
    850                 855                 860                 


Met Ala Lys Ala Arg Glu Gln Tyr Glu Ala Glu Glu Arg Lys Gln Arg 
865                 870                 875                 880 


Ala Glu Leu Leu Gly His Leu Thr Gly Glu Leu Glu Arg Leu Gln Arg 
                885                 890                 895     


Ala His Glu Arg Glu Leu Glu Thr Val Arg Gln Glu Gln His Lys Arg 
            900                 905                 910         


Leu Glu Asp Leu Arg Arg Arg His Arg Glu Gln Glu Arg Lys Leu Gln 
        915                 920                 925             


Asp Leu Glu Leu Asp Leu Glu Thr Arg Ala Lys Asp Val Lys Ala Arg 
    930                 935                 940                 


Leu Ala Leu Leu Glu Val Gln Glu Glu Thr Ala Arg Arg Glu Lys Gln 
945                 950                 955                 960 


Gln Leu Leu Asp Val Gln Arg Gln Val Ala Leu Lys Ser Glu Glu Ala 
                965                 970                 975     


Thr Ala Thr His Gln Gln Leu Glu Glu Ala Gln Lys Glu His Thr His 
            980                 985                 990         


Leu Leu Gln Ser Asn Gln Gln Leu  Arg Glu Ile Leu Asp  Glu Leu Gln 
        995                 1000                 1005             


Ala Arg  Lys Leu Lys Leu Glu  Ser Gln Val Asp Leu  Leu Gln Ala 
    1010                 1015                 1020             


Gln Ser  Gln Gln Leu Gln Lys  His Phe Ser Ser Leu  Glu Ala Glu 
    1025                 1030                 1035             


Ala Gln  Lys Lys Gln His Leu  Leu Arg Glu Val Thr  Val Glu Glu 
    1040                 1045                 1050             


Asn Asn  Ala Ser Pro His Phe  Glu Pro Asp Leu His  Ile Glu Asp 
    1055                 1060                 1065             


Leu Arg  Lys Ser Leu Gly Thr  Asn Gln Thr Lys Glu  Val Ser Ser 
    1070                 1075                 1080             


Ser Leu  Ser Gln Ser Lys Glu  Asp Leu Tyr Leu Asp  Ser Leu Ser 
    1085                 1090                 1095             


Ser His  Asn Val Trp His Leu  Leu Ser Ala Glu Gly  Val Ala Leu 
    1100                 1105                 1110             


Arg Ser  Ala Lys Glu Phe Leu  Val Gln Gln Thr Arg  Ser Met Arg 
    1115                 1120                 1125             


Arg Arg  Gln Thr Ala Leu Lys  Ala Ala Gln Gln His  Trp Arg His 
    1130                 1135                 1140             


Glu Leu  Ala Ser Ala Gln Glu  Val Ala Lys Asp Pro  Pro Gly Ile 
    1145                 1150                 1155             


Lys Ala  Leu Glu Asp Met Arg  Lys Asn Leu Glu Lys  Glu Thr Arg 
    1160                 1165                 1170             


His Leu  Asp Glu Met Lys Ser  Ala Met Arg Lys Gly  His Asn Leu 
    1175                 1180                 1185             


Leu Lys  Lys Lys Glu Glu Lys  Leu Asn Gln Leu Glu  Ser Ser Leu 
    1190                 1195                 1200             


Trp Glu  Glu Ala Ser Asp Glu  Gly Thr Leu Gly Gly  Ser Pro Thr 
    1205                 1210                 1215             


Lys Lys  Ala Val Thr Phe Asp  Leu Ser Asp Met Asp  Ser Leu Ser 
    1220                 1225                 1230             


Ser Glu  Ser Ser Glu Ser Phe  Ser Pro Pro His Leu  Asp Ser Thr 
    1235                 1240                 1245             


Pro Ser  Leu Thr Ser Arg Lys  Ile His Gly Leu Ser  His Ser Leu 
    1250                 1255                 1260             


Arg Gln  Ile Ser Ser Gln Leu  Ser Ser Val Leu Ser  Ile Leu Asp 
    1265                 1270                 1275             


Ser Leu  Asn Pro Gln Ser Pro  Pro Pro Leu Leu Ala  Ser Met Pro 
    1280                 1285                 1290             


Ala Gln  Leu Pro Pro Arg Asp  Pro Lys Ser Thr Pro  Thr Pro Thr 
    1295                 1300                 1305             


Tyr Tyr  Gly Ser Leu Ala Arg  Phe Ser Ala Leu Ser  Ser Ala Thr 
    1310                 1315                 1320             


Pro Thr  Ser Thr Gln Trp Ala  Trp Asp Ser Gly Gln  Gly Pro Arg 
    1325                 1330                 1335             


Leu Pro  Ser Ser Val Ala Gln  Thr Val Asp Asp Phe  Leu Leu Glu 
    1340                 1345                 1350             


Lys Trp  Arg Lys Tyr Phe Pro  Ser Gly Ile Pro Leu  Leu Ser Asn 
    1355                 1360                 1365             


Ser Pro  Thr Pro Leu Glu Ser  Arg Leu Gly Tyr Met  Ser Ala Ser 
    1370                 1375                 1380             


Glu Gln  Leu Arg Leu Leu Gln  His Ser His Ser Gln  Val Pro Glu 
    1385                 1390                 1395             


Ala Gly  Ser Thr Thr Phe Gln  Gly Ile Ile Glu Ala  Asn Arg Arg 
    1400                 1405                 1410             


Trp Leu  Glu Arg Val Lys Asn  Asp Pro Arg Leu Pro  Leu Phe Ser 
    1415                 1420                 1425             


Ser Thr  Pro Lys Pro Lys Ala  Thr Leu Ser Leu Leu  Gln Leu Gly 
    1430                 1435                 1440             


Leu Asp  Glu His Asn Arg Val  Lys Val Tyr Arg Phe  
    1445                 1450                 1455 


<210>  2033
<211>  1486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP170__Homo_sapiens__NP_001035863

<400>  2033

Met Ser Leu Thr Ser Trp Phe Leu Val Ser Ser Gly Gly Thr Arg His 
1               5                   10                  15      


Arg Leu Pro Arg Glu Met Ile Phe Val Gly Arg Asp Asp Cys Glu Leu 
            20                  25                  30          


Met Leu Gln Ser Arg Ser Val Asp Lys Gln His Ala Val Ile Asn Tyr 
        35                  40                  45              


Asp Ala Ser Thr Asp Glu His Leu Val Lys Asp Leu Gly Ser Leu Asn 
    50                  55                  60                  


Gly Thr Phe Val Asn Asp Val Arg Ile Pro Glu Gln Thr Tyr Ile Thr 
65                  70                  75                  80  


Leu Lys Leu Glu Asp Lys Leu Arg Phe Gly Tyr Asp Thr Asn Leu Phe 
                85                  90                  95      


Thr Val Val Gln Gly Glu Met Arg Val Pro Glu Glu Ala Leu Lys His 
            100                 105                 110         


Glu Lys Phe Thr Ile Gln Leu Gln Leu Ser Gln Lys Ser Ser Glu Ser 
        115                 120                 125             


Glu Leu Ser Lys Ser Ala Ser Ala Lys Ser Ile Asp Ser Lys Val Ala 
    130                 135                 140                 


Asp Ala Ala Thr Glu Val Gln His Lys Thr Thr Glu Ala Leu Lys Ser 
145                 150                 155                 160 


Glu Glu Lys Ala Met Asp Ile Ser Ala Met Pro Arg Gly Thr Pro Leu 
                165                 170                 175     


Tyr Gly Gln Pro Ser Trp Trp Gly Asp Asp Glu Val Asp Glu Lys Arg 
            180                 185                 190         


Ala Phe Lys Thr Asn Gly Lys Pro Glu Glu Lys Asn His Glu Ala Gly 
        195                 200                 205             


Thr Ser Gly Cys Gly Ile Asp Ala Lys Gln Val Glu Glu Gln Ser Ala 
    210                 215                 220                 


Ala Ala Asn Glu Glu Val Leu Phe Pro Phe Cys Arg Glu Pro Ser Tyr 
225                 230                 235                 240 


Phe Glu Ile Pro Thr Lys Glu Phe Gln Gln Pro Ser Gln Ile Thr Glu 
                245                 250                 255     


Ser Thr Ile His Glu Ile Pro Thr Lys Asp Thr Pro Ser Ser His Ile 
            260                 265                 270         


Thr Gly Ala Gly His Ala Ser Phe Thr Ile Glu Phe Asp Asp Ser Thr 
        275                 280                 285             


Pro Gly Lys Val Thr Ile Arg Asp His Val Thr Lys Phe Thr Ser Asp 
    290                 295                 300                 


Gln Arg His Lys Ser Lys Lys Ser Ser Pro Gly Thr Gln Asp Leu Leu 
305                 310                 315                 320 


Gly Ile Gln Thr Gly Met Met Ala Pro Glu Asn Lys Val Ala Asp Trp 
                325                 330                 335     


Leu Ala Gln Asn Asn Pro Pro Gln Met Leu Trp Glu Arg Thr Glu Glu 
            340                 345                 350         


Asp Ser Lys Ser Ile Lys Ser Asp Val Pro Val Tyr Leu Lys Arg Leu 
        355                 360                 365             


Lys Gly Asn Lys His Asp Asp Gly Thr Gln Ser Asp Ser Glu Asn Ala 
    370                 375                 380                 


Gly Ala His Arg Arg Cys Ser Lys Arg Ala Thr Leu Glu Glu His Leu 
385                 390                 395                 400 


Arg Arg His His Ser Glu His Lys Lys Leu Gln Lys Val Gln Ala Thr 
                405                 410                 415     


Glu Lys His Gln Asp Gln Ala Val Val Phe Gly Val Asp Asp Asn Gln 
            420                 425                 430         


Asp Tyr Asn Arg Pro Val Ile Asn Glu Lys His Lys Asp Leu Ile Lys 
        435                 440                 445             


Asp Trp Ala Leu Ser Ser Ala Ala Ala Val Met Glu Glu Arg Lys Pro 
    450                 455                 460                 


Leu Thr Thr Ser Gly Phe His His Ser Glu Glu Gly Thr Ser Ser Ser 
465                 470                 475                 480 


Gly Ser Lys Arg Trp Val Ser Gln Trp Ala Ser Leu Ala Ala Asn His 
                485                 490                 495     


Thr Arg His Asp Gln Glu Glu Arg Ile Met Glu Phe Ser Ala Pro Leu 
            500                 505                 510         


Pro Leu Glu Asn Glu Thr Glu Ile Ser Glu Ser Gly Met Thr Val Arg 
        515                 520                 525             


Ser Thr Gly Ser Ala Thr Ser Leu Ala Ser Gln Gly Glu Arg Arg Arg 
    530                 535                 540                 


Arg Thr Leu Pro Gln Leu Pro Asn Glu Glu Lys Ser Leu Glu Ser His 
545                 550                 555                 560 


Arg Ala Lys Val Val Thr Gln Arg Ser Glu Ile Gly Glu Lys Gln Asp 
                565                 570                 575     


Thr Glu Leu Gln Glu Lys Glu Thr Pro Thr Gln Val Tyr Gln Lys Asp 
            580                 585                 590         


Lys Gln Asp Ala Asp Arg Pro Leu Ser Lys Met Asn Arg Ala Val Asn 
        595                 600                 605             


Gly Glu Thr Leu Lys Thr Gly Gly Asp Asn Lys Thr Leu Leu His Leu 
    610                 615                 620                 


Gly Ser Ser Ala Pro Gly Lys Glu Lys Ser Glu Thr Asp Lys Glu Thr 
625                 630                 635                 640 


Ser Leu Val Lys Gln Thr Leu Ala Lys Leu Gln Gln Gln Glu Gln Arg 
                645                 650                 655     


Glu Glu Ala Gln Trp Thr Pro Thr Lys Leu Ser Ser Lys Asn Val Ser 
            660                 665                 670         


Gly Gln Thr Asp Lys Cys Arg Glu Glu Thr Phe Lys Gln Glu Ser Gln 
        675                 680                 685             


Pro Pro Glu Lys Asn Ser Gly His Ser Thr Ser Lys Gly Asp Arg Val 
    690                 695                 700                 


Ala Gln Ser Glu Ser Lys Arg Arg Lys Ala Glu Glu Ile Leu Lys Ser 
705                 710                 715                 720 


Gln Thr Pro Lys Gly Gly Asp Lys Lys Glu Ser Ser Lys Ser Leu Val 
                725                 730                 735     


Arg Gln Gly Ser Phe Thr Ile Glu Lys Pro Ser Pro Asn Ile Pro Ile 
            740                 745                 750         


Glu Leu Ile Pro His Ile Asn Lys Gln Thr Ser Ser Thr Pro Ser Ser 
        755                 760                 765             


Leu Ala Leu Thr Ser Ala Ser Arg Ile Arg Glu Arg Ser Glu Ser Leu 
    770                 775                 780                 


Asp Pro Asp Ser Ser Met Asp Thr Thr Leu Ile Leu Lys Asp Thr Glu 
785                 790                 795                 800 


Ala Val Met Ala Phe Leu Glu Ala Lys Leu Arg Glu Asp Asn Lys Thr 
                805                 810                 815     


Asp Glu Gly Pro Asp Thr Pro Ser Tyr Asn Arg Asp Asn Ser Ile Ser 
            820                 825                 830         


Pro Glu Ser Asp Val Asp Thr Ala Ser Thr Ile Ser Leu Val Thr Gly 
        835                 840                 845             


Glu Thr Glu Arg Lys Ser Thr Gln Lys Arg Lys Ser Phe Thr Ser Leu 
    850                 855                 860                 


Tyr Lys Asp Arg Cys Ser Thr Gly Ser Pro Ser Lys Asp Val Thr Lys 
865                 870                 875                 880 


Ser Ser Ser Ser Gly Ala Arg Glu Lys Met Glu Lys Lys Thr Lys Ser 
                885                 890                 895     


Arg Ser Thr Asp Val Gly Ser Arg Ala Asp Gly Arg Lys Phe Val Gln 
            900                 905                 910         


Ser Ser Gly Arg Ile Arg Gln Pro Ser Val Asp Leu Thr Asp Asp Asp 
        915                 920                 925             


Gln Thr Ser Ser Val Pro His Ser Ala Ile Ser Asp Ile Met Ser Ser 
    930                 935                 940                 


Asp Gln Glu Thr Tyr Ser Cys Lys Pro His Gly Arg Thr Pro Leu Thr 
945                 950                 955                 960 


Ser Ala Asp Glu His Val His Ser Lys Leu Glu Gly Ser Lys Val Thr 
                965                 970                 975     


Lys Ser Lys Thr Ser Pro Val Val Ser Gly Ser Ser Ser Lys Ser Thr 
            980                 985                 990         


Thr Leu Pro Arg Pro Arg Pro Thr  Arg Thr Ser Leu Leu  Arg Arg Ala 
        995                 1000                 1005             


Arg Leu  Gly Glu Ala Ser Asp  Ser Glu Leu Ala Asp  Ala Asp Lys 
    1010                 1015                 1020             


Ala Ser  Val Ala Ser Glu Val  Ser Thr Thr Ser Ser  Thr Ser Lys 
    1025                 1030                 1035             


Pro Pro  Thr Gly Arg Arg Asn  Ile Ser Arg Ile Asp  Leu Leu Ala 
    1040                 1045                 1050             


Gln Pro  Arg Arg Thr Arg Leu  Gly Ser Leu Ser Ala  Arg Ser Asp 
    1055                 1060                 1065             


Ser Glu  Ala Thr Ile Ser Arg  Ser Ser Ala Ser Ser  Arg Thr Ala 
    1070                 1075                 1080             


Glu Ala  Ile Ile Arg Ser Gly  Ala Arg Leu Val Pro  Ser Asp Lys 
    1085                 1090                 1095             


Phe Ser  Pro Arg Ile Arg Ala  Asn Ser Ile Ser Arg  Leu Ser Asp 
    1100                 1105                 1110             


Ser Lys  Val Lys Ser Met Thr  Ser Ala His Gly Ser  Ala Ser Val 
    1115                 1120                 1125             


Asn Ser  Arg Trp Arg Arg Phe  Pro Thr Asp Tyr Ala  Ser Thr Ser 
    1130                 1135                 1140             


Glu Asp  Glu Phe Gly Ser Asn  Arg Asn Ser Pro Lys  His Thr Arg 
    1145                 1150                 1155             


Leu Arg  Thr Ser Pro Ala Leu  Lys Thr Thr Arg Leu  Gln Ser Ala 
    1160                 1165                 1170             


Gly Ser  Ala Met Pro Thr Ser  Ser Ser Phe Lys His  Arg Ile Lys 
    1175                 1180                 1185             


Glu Gln  Glu Asp Tyr Ile Arg  Asp Trp Thr Ala His  Arg Glu Glu 
    1190                 1195                 1200             


Ile Ala  Arg Ile Ser Gln Asp  Leu Ala Leu Ile Ala  Arg Glu Ile 
    1205                 1210                 1215             


Asn Asp  Val Ala Gly Glu Ile  Asp Ser Val Thr Ser  Ser Gly Thr 
    1220                 1225                 1230             


Ala Pro  Ser Thr Thr Val Ser  Thr Ala Ala Thr Thr  Pro Gly Ser 
    1235                 1240                 1245             


Ala Ile  Asp Thr Arg Glu Glu  Leu Val Asp Arg Val  Phe Asp Glu 
    1250                 1255                 1260             


Ser Leu  Asn Phe Arg Lys Ile  Pro Pro Leu Val His  Ser Lys Thr 
    1265                 1270                 1275             


Pro Glu  Gly Asn Asn Gly Arg  Ser Gly Asp Pro Arg  Pro Gln Ala 
    1280                 1285                 1290             


Ala Glu  Pro Pro Asp His Leu  Thr Ile Thr Arg Arg  Arg Thr Trp 
    1295                 1300                 1305             


Ser Arg  Asp Glu Val Met Gly  Asp Asn Leu Leu Leu  Ser Ser Val 
    1310                 1315                 1320             


Phe Gln  Phe Ser Lys Lys Ile  Arg Gln Ser Ile Asp  Lys Thr Ala 
    1325                 1330                 1335             


Gly Lys  Ile Arg Ile Leu Phe  Lys Asp Lys Asp Arg  Asn Trp Asp 
    1340                 1345                 1350             


Asp Ile  Glu Ser Lys Leu Arg  Ala Glu Ser Glu Val  Pro Ile Val 
    1355                 1360                 1365             


Lys Thr  Ser Ser Met Glu Ile  Ser Ser Ile Leu Gln  Glu Leu Lys 
    1370                 1375                 1380             


Arg Val  Glu Lys Gln Leu Gln  Ala Ile Asn Ala Met  Ile Asp Pro 
    1385                 1390                 1395             


Asp Gly  Thr Leu Glu Ala Leu  Asn Asn Met Gly Phe  Pro Ser Ala 
    1400                 1405                 1410             


Met Leu  Pro Ser Pro Pro Lys  Gln Lys Ser Ser Pro  Val Asn Asn 
    1415                 1420                 1425             


His His  Ser Pro Gly Gln Thr  Pro Thr Leu Gly Gln  Pro Glu Ala 
    1430                 1435                 1440             


Arg Ala  Leu His Pro Ala Ala  Val Ser Ala Ala Ala  Glu Phe Glu 
    1445                 1450                 1455             


Asn Ala  Glu Ser Glu Ala Asp  Phe Ser Ile His Phe  Asn Arg Phe 
    1460                 1465                 1470             


Asn Pro  Asp Gly Glu Glu Glu  Asp Val Thr Val Gln  Glu 
    1475                 1480                 1485     


<210>  2034
<211>  2537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP192__Homo_sapiens__NP_115518

<400>  2034

Met Glu Asp Phe Arg Gly Ile Ala Glu Glu Ser Phe Pro Ser Phe Leu 
1               5                   10                  15      


Thr Asn Ser Leu Phe Gly Asn Ser Gly Ile Leu Glu Asn Val Thr Leu 
            20                  25                  30          


Ser Ser Asn Leu Gly Leu Pro Val Ala Val Ser Thr Leu Ala Arg Asp 
        35                  40                  45              


Arg Ser Ser Thr Asp Asn Arg Tyr Pro Asp Ile Gln Ala Ser Tyr Leu 
    50                  55                  60                  


Val Glu Gly Arg Phe Ser Val Pro Ser Gly Ser Ser Pro Gly Ser Gln 
65                  70                  75                  80  


Ser Asp Ala Glu Pro Arg Glu Arg Leu Gln Leu Ser Phe Gln Asp Asp 
                85                  90                  95      


Asp Ser Ile Ser Arg Lys Lys Ser Tyr Val Glu Ser Gln Arg Leu Ser 
            100                 105                 110         


Asn Ala Leu Ser Lys Gln Ser Ala Leu Gln Met Glu Thr Ala Gly Pro 
        115                 120                 125             


Glu Glu Glu Pro Ala Gly Ala Thr Glu Ser Leu Gln Gly Gln Asp Leu 
    130                 135                 140                 


Phe Asn Arg Ala Ser Pro Leu Glu Gln Ala Gln Asp Ser Pro Ile Asp 
145                 150                 155                 160 


Phe His Leu Gln Ser Trp Met Asn Asn Lys Glu Pro Lys Ile Val Val 
                165                 170                 175     


Leu Asp Ala Gly Lys His Phe Glu Asp Lys Thr Leu Lys Ser Asp Leu 
            180                 185                 190         


Ser His Thr Ser Leu Leu Glu Asn Glu Lys Leu Ile Leu Pro Thr Ser 
        195                 200                 205             


Leu Glu Asp Ser Ser Asp Asp Asp Ile Asp Asp Glu Met Phe Tyr Asp 
    210                 215                 220                 


Asp His Leu Glu Ala Tyr Phe Glu Gln Leu Ala Ile Pro Gly Met Ile 
225                 230                 235                 240 


Tyr Glu Asp Leu Glu Gly Pro Glu Pro Pro Glu Lys Gly Phe Lys Leu 
                245                 250                 255     


Pro Thr Asn Gly Leu Arg Gln Ala Asn Glu Asn Gly Ser Leu Asn Cys 
            260                 265                 270         


Lys Phe Gln Ser Glu Asn Asn Ser Ser Leu Ile Ser Leu Asp Ser His 
        275                 280                 285             


Ser Ser Glu Thr Thr His Lys Glu Ser Glu Glu Ser Gln Val Ile Cys 
    290                 295                 300                 


Leu Pro Gly Thr Ser Asn Ser Ile Gly Thr Gly Asp Ser Arg Arg Tyr 
305                 310                 315                 320 


Thr Asp Gly Met Leu Pro Phe Ser Ser Gly Thr Trp Gly Thr Glu Lys 
                325                 330                 335     


Glu Ile Glu Asn Leu Lys Gly Ile Val Pro Asp Leu Asn Ser Glu Cys 
            340                 345                 350         


Ala Ser Lys Asp Val Leu Val Lys Thr Leu Arg Ala Ile Asp Val Lys 
        355                 360                 365             


Leu Asn Ser Asp Asn Phe His Asp Ala Asn Ala Asn Arg Gly Gly Phe 
    370                 375                 380                 


Asp Leu Thr Asp Pro Val Lys Gln Gly Ala Glu Cys Pro His Gln Asn 
385                 390                 395                 400 


Lys Thr Val Leu His Met Asp Gly Cys Leu Asp Thr Glu Thr Pro Thr 
                405                 410                 415     


Val Ser Ile Gln Glu Asn Val Asp Val Ala Ser Leu Lys Pro Ile Ser 
            420                 425                 430         


Asp Ser Gly Ile Asn Phe Thr Asp Ala Ile Trp Ser Pro Thr Cys Glu 
        435                 440                 445             


Arg Arg Thr Cys Glu Cys His Glu Ser Ile Glu Lys Asn Lys Asp Lys 
    450                 455                 460                 


Thr Asp Leu Pro Gln Ser Val Val Tyr Gln Asn Glu Glu Gly Arg Trp 
465                 470                 475                 480 


Val Thr Asp Leu Ala Tyr Tyr Thr Ser Phe Asn Ser Lys Gln Asn Leu 
                485                 490                 495     


Asn Val Ser Leu Ser Asp Glu Met Asn Glu Asp Phe Arg Ser Gly Ser 
            500                 505                 510         


Glu Ala Phe Asp Leu Ile Ala Gln Asp Glu Glu Glu Phe Asn Lys Glu 
        515                 520                 525             


His Gln Phe Ile Gln Glu Glu Asn Ile Asp Ala His Asn Thr Ser Val 
    530                 535                 540                 


Ala Leu Gly Asp Thr Ser Trp Gly Ala Thr Ile Asn Tyr Ser Leu Leu 
545                 550                 555                 560 


Arg Lys Ser Arg Ser Thr Ser Asp Leu Asp Lys Asp Asp Ala Ser Tyr 
                565                 570                 575     


Leu Arg Leu Ser Leu Gly Glu Phe Phe Ala Gln Arg Ser Glu Ala Leu 
            580                 585                 590         


Gly Cys Leu Gly Gly Gly Asn Asn Val Lys Arg Pro Ser Phe Gly Tyr 
        595                 600                 605             


Phe Ile Arg Ser Pro Glu Lys Arg Glu Pro Ile Ala Leu Ile Arg Lys 
    610                 615                 620                 


Ser Asp Val Ser Arg Gly Asn Leu Glu Lys Glu Met Ala His Leu Asn 
625                 630                 635                 640 


His Asp Leu Tyr Ser Gly Asp Leu Asn Glu Gln Ser Gln Ala Gln Leu 
                645                 650                 655     


Ser Glu Gly Ser Ile Thr Leu Gln Val Glu Ala Val Glu Ser Thr Ser 
            660                 665                 670         


Gln Val Asp Glu Asn Asp Val Thr Leu Thr Ala Asp Lys Gly Lys Thr 
        675                 680                 685             


Glu Asp Thr Phe Phe Met Ser Asn Lys Pro Gln Arg Tyr Lys Asp Lys 
    690                 695                 700                 


Leu Pro Asp Ser Gly Asp Ser Met Leu Arg Ile Ser Thr Ile Ala Ser 
705                 710                 715                 720 


Ala Ile Ala Glu Ala Ser Val Asn Thr Asp Pro Ser Gln Leu Ala Ala 
                725                 730                 735     


Met Ile Lys Ala Leu Ser Asn Lys Thr Arg Asp Lys Thr Phe Gln Glu 
            740                 745                 750         


Asp Glu Lys Gln Lys Asp Tyr Ser His Val Arg His Phe Leu Pro Asn 
        755                 760                 765             


Asp Leu Glu Lys Ser Asn Gly Ser Asn Ala Leu Asp Met Glu Lys Tyr 
    770                 775                 780                 


Leu Lys Lys Thr Glu Val Ser Arg Tyr Glu Ser Ala Leu Glu Asn Phe 
785                 790                 795                 800 


Ser Arg Ala Ser Met Ser Asp Thr Trp Asp Leu Ser Leu Pro Lys Glu 
                805                 810                 815     


Gln Thr Thr Gln Asp Ile His Pro Val Asp Leu Ser Ala Thr Ser Val 
            820                 825                 830         


Ser Val Arg Ala Pro Glu Glu Asn Thr Ala Ala Ile Val Tyr Val Glu 
        835                 840                 845             


Asn Gly Glu Ser Glu Asn Gln Glu Ser Phe Arg Thr Ile Asn Ser Ser 
    850                 855                 860                 


Asn Ser Val Thr Asn Arg Glu Asn Asn Ser Ala Val Val Asp Val Lys 
865                 870                 875                 880 


Thr Cys Ser Ile Asp Asn Lys Leu Gln Asp Val Gly Asn Asp Glu Lys 
                885                 890                 895     


Ala Thr Ser Ile Ser Thr Pro Ser Asp Ser Tyr Ser Ser Val Arg Asn 
            900                 905                 910         


Pro Arg Ile Thr Ser Leu Cys Leu Leu Lys Asp Cys Glu Glu Ile Arg 
        915                 920                 925             


Asp Asn Arg Glu Asn Gln Arg Gln Asn Glu Cys Val Ser Glu Ile Ser 
    930                 935                 940                 


Asn Ser Glu Lys His Val Thr Phe Glu Asn His Arg Ile Val Ser Pro 
945                 950                 955                 960 


Lys Asn Ser Asp Leu Lys Asn Thr Ser Pro Glu His Gly Gly Arg Gly 
                965                 970                 975     


Ser Glu Asp Glu Gln Glu Ser Phe Arg Pro Ser Thr Ser Pro Leu Ser 
            980                 985                 990         


His Ser Ser Pro Ser Glu Ile Ser  Gly Thr Ser Ser Ser  Gly Cys Ala 
        995                 1000                 1005             


Leu Glu  Ser Phe Gly Ser Ala  Ala Gln Gln Gln Gln  Pro Pro Cys 
    1010                 1015                 1020             


Glu Gln  Glu Leu Ser Pro Leu  Val Cys Ser Pro Ala  Gly Val Ser 
    1025                 1030                 1035             


Arg Leu  Thr Tyr Val Ser Glu  Pro Glu Ser Ser Tyr  Pro Thr Thr 
    1040                 1045                 1050             


Ala Thr  Asp Asp Ala Leu Glu  Asp Arg Lys Ser Asp  Ile Thr Ser 
    1055                 1060                 1065             


Glu Leu  Ser Thr Thr Ile Ile  Gln Gly Ser Pro Ala  Ala Leu Glu 
    1070                 1075                 1080             


Glu Arg  Ala Met Glu Lys Leu  Arg Glu Lys Val Pro  Phe Gln Asn 
    1085                 1090                 1095             


Arg Gly  Lys Gly Thr Leu Ser  Ser Ile Ile Gln Asn  Asn Ser Asp 
    1100                 1105                 1110             


Thr Arg  Lys Ala Thr Glu Thr  Thr Ser Leu Ser Ser  Lys Pro Glu 
    1115                 1120                 1125             


Tyr Val  Lys Pro Asp Phe Arg  Trp Ser Lys Asp Pro  Ser Ser Lys 
    1130                 1135                 1140             


Ser Gly  Asn Leu Leu Glu Thr  Ser Glu Val Gly Trp  Thr Ser Asn 
    1145                 1150                 1155             


Pro Glu  Glu Leu Asp Pro Ile  Arg Leu Ala Leu Leu  Gly Lys Ser 
    1160                 1165                 1170             


Gly Leu  Ser Cys Gln Val Gly  Ser Ala Thr Ser His  Pro Val Ser 
    1175                 1180                 1185             


Cys Gln  Glu Pro Ile Asp Glu  Asp Gln Arg Ile Ser  Pro Lys Asp 
    1190                 1195                 1200             


Lys Ser  Thr Ala Gly Arg Glu  Phe Ser Gly Gln Val  Ser His Gln 
    1205                 1210                 1215             


Thr Thr  Ser Glu Asn Gln Cys  Thr Pro Ile Pro Ser  Ser Thr Val 
    1220                 1225                 1230             


His Ser  Ser Val Ala Asp Met  Gln Asn Met Pro Ala  Ala Val His 
    1235                 1240                 1245             


Ala Leu  Leu Thr Gln Pro Ser  Leu Ser Ala Ala Pro  Phe Ala Gln 
    1250                 1255                 1260             


Arg Tyr  Leu Gly Thr Leu Pro  Ser Thr Gly Ser Thr  Thr Leu Pro 
    1265                 1270                 1275             


Gln Cys  His Ala Gly Asn Ala  Thr Val Cys Gly Phe  Ser Gly Gly 
    1280                 1285                 1290             


Leu Pro  Tyr Pro Ala Val Ala  Gly Glu Pro Val Gln  Asn Ser Val 
    1295                 1300                 1305             


Ala Val  Gly Ile Cys Leu Gly  Ser Asn Ile Gly Ser  Gly Trp Met 
    1310                 1315                 1320             


Gly Thr  Ser Ser Leu Cys Asn  Pro Tyr Ser Asn Thr  Leu Asn Gln 
    1325                 1330                 1335             


Asn Leu  Leu Ser Thr Thr Lys  Pro Phe Pro Val Pro  Ser Val Gly 
    1340                 1345                 1350             


Thr Asn  Cys Gly Ile Glu Pro  Trp Asp Ser Gly Val  Thr Ser Gly 
    1355                 1360                 1365             


Leu Gly  Ser Val Arg Val Pro  Glu Glu Leu Lys Leu  Pro His Ala 
    1370                 1375                 1380             


Cys Cys  Val Gly Ile Ala Ser  Gln Thr Leu Leu Ser  Val Leu Asn 
    1385                 1390                 1395             


Pro Thr  Asp Arg Trp Leu Gln  Val Ser Ile Gly Val  Leu Ser Ile 
    1400                 1405                 1410             


Ser Val  Asn Gly Glu Lys Val  Asp Leu Ser Thr Tyr  Arg Cys Leu 
    1415                 1420                 1425             


Val Phe  Lys Asn Lys Ala Ile  Ile Arg Pro His Ala  Thr Glu Glu 
    1430                 1435                 1440             


Ile Lys  Val Leu Phe Ile Pro  Ser Ser Pro Gly Val  Phe Arg Cys 
    1445                 1450                 1455             


Thr Phe  Ser Val Ala Ser Trp  Pro Cys Ser Thr Asp  Ala Glu Thr 
    1460                 1465                 1470             


Ile Val  Gln Ala Glu Ala Leu  Ala Ser Thr Val Thr  Leu Thr Ala 
    1475                 1480                 1485             


Ile Ala  Glu Ser Pro Val Ile  Glu Val Glu Thr Glu  Lys Lys Asp 
    1490                 1495                 1500             


Val Leu  Asp Phe Gly Asp Leu  Thr Tyr Gly Gly Trp  Lys Ala Leu 
    1505                 1510                 1515             


Pro Leu  Lys Leu Ile Asn Arg  Thr His Ala Thr Val  Pro Ile Arg 
    1520                 1525                 1530             


Leu Ile  Ile Asn Ala Asn Ala  Val Ala Trp Arg Cys  Phe Thr Phe 
    1535                 1540                 1545             


Ser Lys  Glu Ser Val Arg Ala  Pro Val Glu Val Ala  Pro Cys Ala 
    1550                 1555                 1560             


Asp Val  Val Thr Arg Leu Ala  Gly Pro Ser Val Val  Asn His Met 
    1565                 1570                 1575             


Met Pro  Ala Ser Tyr Asp Gly  Gln Asp Pro Glu Phe  Leu Met Ile 
    1580                 1585                 1590             


Trp Val  Leu Phe His Ser Pro  Lys Lys Gln Ile Ser  Ser Ser Asp 
    1595                 1600                 1605             


Ile Leu  Asp Ser Ala Glu Glu  Phe Ser Ala Lys Val  Asp Ile Glu 
    1610                 1615                 1620             


Val Asp  Ser Pro Asn Pro Thr  Pro Val Leu Arg Ser  Val Ser Leu 
    1625                 1630                 1635             


Arg Ala  Arg Ala Gly Ile Ala  Arg Ile His Ala Pro  Arg Asp Leu 
    1640                 1645                 1650             


Gln Thr  Met His Phe Leu Ala  Lys Val Ala Ser Ser  Arg Lys Gln 
    1655                 1660                 1665             


His Leu  Pro Leu Lys Asn Ala  Gly Asn Ile Glu Val  Tyr Leu Asp 
    1670                 1675                 1680             


Ile Lys  Val Pro Glu Gln Gly  Ser His Phe Ser Val  Asp Pro Lys 
    1685                 1690                 1695             


Asn Leu  Leu Leu Lys Pro Gly  Glu Glu His Glu Val  Ile Val Ser 
    1700                 1705                 1710             


Phe Thr  Pro Lys Asp Pro Glu  Ala Cys Glu Glu Arg  Ile Leu Lys 
    1715                 1720                 1725             


Ile Phe  Val Gln Pro Phe Gly  Pro Gln Tyr Glu Val  Val Leu Lys 
    1730                 1735                 1740             


Gly Glu  Val Ile Ser Ser Gly  Ser Lys Pro Leu Ser  Pro Gly Pro 
    1745                 1750                 1755             


Cys Leu  Asp Ile Pro Ser Ile  Leu Ser Asn Lys Gln  Phe Leu Ala 
    1760                 1765                 1770             


Trp Gly  Gly Val Pro Leu Gly  Arg Thr Gln Leu Gln  Lys Leu Ala 
    1775                 1780                 1785             


Leu Arg  Asn Asn Ser Ala Ser  Thr Thr Gln His Leu  Arg Leu Leu 
    1790                 1795                 1800             


Ile Arg  Gly Gln Asp Gln Asp  Cys Phe Gln Leu Gln  Asn Thr Phe 
    1805                 1810                 1815             


Gly Ser  Glu Gln Arg Leu Thr  Ser Asn Cys Glu Ile  Arg Ile His 
    1820                 1825                 1830             


Pro Lys  Glu Asp Ile Phe Ile  Ser Val Leu Phe Ala  Pro Thr Arg 
    1835                 1840                 1845             


Leu Ser  Cys Met Leu Ala Arg  Leu Glu Ile Lys Gln  Leu Gly Asn 
    1850                 1855                 1860             


Arg Ser  Gln Pro Gly Ile Lys  Phe Thr Ile Pro Leu  Ser Gly Tyr 
    1865                 1870                 1875             


Gly Gly  Thr Ser Asn Leu Ile  Leu Glu Gly Val Lys  Lys Leu Ser 
    1880                 1885                 1890             


Asp Ser  Tyr Met Val Thr Val  Asn Gly Leu Val Pro  Gly Lys Glu 
    1895                 1900                 1905             


Ser Lys  Ile Val Phe Ser Val  Arg Asn Thr Gly Ser  Arg Ala Ala 
    1910                 1915                 1920             


Phe Val  Lys Ala Val Gly Phe  Lys Asp Ser Gln Lys  Lys Val Leu 
    1925                 1930                 1935             


Leu Asp  Pro Lys Val Leu Arg  Ile Phe Pro Asp Lys  Phe Val Leu 
    1940                 1945                 1950             


Lys Glu  Arg Thr Gln Glu Asn  Val Thr Leu Ile Tyr  Asn Pro Ser 
    1955                 1960                 1965             


Asp Arg  Gly Ile Asn Asn Lys  Thr Ala Thr Glu Leu  Ser Thr Val 
    1970                 1975                 1980             


Tyr Leu  Phe Gly Gly Asp Glu  Ile Ser Arg Gln Gln  Tyr Arg Arg 
    1985                 1990                 1995             


Ala Leu  Leu His Lys Pro Glu  Met Ile Lys Gln Ile  Leu Pro Glu 
    2000                 2005                 2010             


His Ser  Val Leu Gln Asn Ile  Asn Phe Val Glu Ala  Phe Gln Asp 
    2015                 2020                 2025             


Glu Leu  Leu Val Thr Glu Val  Tyr Asp Leu Pro Gln  Arg Pro Asn 
    2030                 2035                 2040             


Asp Val  Gln Leu Phe Tyr Gly  Ser Met Cys Lys Ile  Ile Leu Ser 
    2045                 2050                 2055             


Val Ile  Gly Glu Phe Arg Asp  Cys Ile Ser Ser Arg  Glu Phe Leu 
    2060                 2065                 2070             


Gln Pro  Ser Ser Lys Ala Ser  Leu Glu Ser Thr Ser  Asp Leu Gly 
    2075                 2080                 2085             


Ala Ser  Gly Lys His Gly Gly  Asn Val Ser Leu Asp  Val Leu Pro 
    2090                 2095                 2100             


Val Lys  Gly Pro Gln Gly Ser  Pro Leu Leu Ser Arg  Ala Ala Arg 
    2105                 2110                 2115             


Pro Pro  Leu Asp Gln Leu Ala  Ser Glu Glu Pro Trp  Thr Val Leu 
    2120                 2125                 2130             


Pro Glu  His Leu Ile Leu Val  Ala Pro Ser Pro Cys  Asp Met Ala 
    2135                 2140                 2145             


Lys Thr  Gly Arg Phe Gln Ile  Val Asn Asn Ser Val  Arg Leu Leu 
    2150                 2155                 2160             


Arg Phe  Glu Leu Cys Trp Pro  Ala His Cys Leu Thr  Val Thr Pro 
    2165                 2170                 2175             


Gln His  Gly Cys Val Ala Pro  Glu Ser Lys Leu Gln  Ile Leu Val 
    2180                 2185                 2190             


Ser Pro  Asn Ser Ser Leu Ser  Thr Lys Gln Ser Met  Phe Pro Trp 
    2195                 2200                 2205             


Ser Gly  Leu Ile Tyr Ile His  Cys Asp Asp Gly Gln  Lys Lys Ile 
    2210                 2215                 2220             


Val Lys  Val Gln Ile Arg Glu  Asp Leu Thr Gln Val  Glu Leu Leu 
    2225                 2230                 2235             


Thr Arg  Leu Thr Ser Lys Pro  Phe Gly Ile Leu Ser  Pro Val Ser 
    2240                 2245                 2250             


Glu Pro  Ser Val Ser His Leu  Val Lys Pro Met Thr  Lys Pro Pro 
    2255                 2260                 2265             


Ser Thr  Lys Val Glu Ile Arg  Asn Lys Ser Ile Thr  Phe Pro Thr 
    2270                 2275                 2280             


Thr Glu  Pro Gly Glu Thr Ser  Glu Ser Cys Leu Glu  Leu Glu Asn 
    2285                 2290                 2295             


His Gly  Thr Thr Asp Val Lys  Trp His Leu Ser Ser  Leu Ala Pro 
    2300                 2305                 2310             


Pro Tyr  Val Lys Gly Val Asp  Glu Ser Gly Asp Val  Phe Arg Ala 
    2315                 2320                 2325             


Thr Tyr  Ala Ala Phe Arg Cys  Ser Pro Ile Ser Gly  Leu Leu Glu 
    2330                 2335                 2340             


Ser His  Gly Ile Gln Lys Val  Ser Ile Thr Phe Leu  Pro Arg Gly 
    2345                 2350                 2355             


Arg Gly  Asp Tyr Ala Gln Phe  Trp Asp Val Glu Cys  His Pro Leu 
    2360                 2365                 2370             


Lys Glu  Pro His Met Lys His  Thr Leu Arg Phe Gln  Leu Ser Gly 
    2375                 2380                 2385             


Gln Ser  Ile Glu Ala Glu Asn  Glu Pro Glu Asn Ala  Cys Leu Ser 
    2390                 2395                 2400             


Thr Asp  Ser Leu Ile Lys Ile  Asp His Leu Val Lys  Pro Arg Arg 
    2405                 2410                 2415             


Gln Ala  Val Ser Glu Ala Ser  Ala Arg Ile Pro Glu  Gln Leu Asp 
    2420                 2425                 2430             


Val Thr  Ala Arg Gly Val Tyr  Ala Pro Glu Asp Val  Tyr Arg Phe 
    2435                 2440                 2445             


Arg Pro  Thr Ser Val Gly Glu  Ser Arg Thr Leu Lys  Val Asn Leu 
    2450                 2455                 2460             


Arg Asn  Asn Ser Phe Ile Thr  His Ser Leu Lys Phe  Leu Ser Pro 
    2465                 2470                 2475             


Arg Glu  Pro Phe Tyr Val Lys  His Ser Lys Tyr Ser  Leu Arg Ala 
    2480                 2485                 2490             


Gln His  Tyr Ile Asn Met Pro  Val Gln Phe Lys Pro  Lys Ser Ala 
    2495                 2500                 2505             


Gly Lys  Phe Glu Ala Leu Leu  Val Ile Gln Thr Asp  Glu Gly Lys 
    2510                 2515                 2520             


Ser Ile  Ala Ile Arg Leu Ile  Gly Glu Ala Leu Gly  Lys Asn 
    2525                 2530                 2535         


<210>  2035
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP19__Homo_sapiens__NP_116287

<400>  2035

Met Tyr Met Gly Met Met Cys Thr Ala Lys Lys Cys Gly Ile Arg Phe 
1               5                   10                  15      


Gln Pro Pro Ala Ile Ile Leu Ile Tyr Glu Ser Glu Ile Lys Gly Lys 
            20                  25                  30          


Ile Arg Gln Arg Ile Met Pro Val Arg Asn Phe Ser Lys Phe Ser Asp 
        35                  40                  45              


Cys Thr Arg Ala Ala Glu Gln Leu Lys Asn Asn Pro Arg His Lys Ser 
    50                  55                  60                  


Tyr Leu Glu Gln Val Ser Leu Arg Gln Leu Glu Lys Leu Phe Ser Phe 
65                  70                  75                  80  


Leu Arg Gly Tyr Leu Ser Gly Gln Ser Leu Ala Glu Thr Met Glu Gln 
                85                  90                  95      


Ile Gln Arg Glu Thr Thr Ile Asp Pro Glu Glu Asp Leu Asn Lys Leu 
            100                 105                 110         


Asp Asp Lys Glu Leu Ala Lys Arg Lys Ser Ile Met Asp Glu Leu Phe 
        115                 120                 125             


Glu Lys Asn Gln Lys Lys Lys Asp Asp Pro Asn Phe Val Tyr Asp Ile 
    130                 135                 140                 


Glu Val Glu Phe Pro Gln Asp Asp Gln Leu Gln Ser Cys Gly Trp Asp 
145                 150                 155                 160 


Thr Glu Ser Ala Asp Glu Phe 
                165         


<210>  2036
<211>  2442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP250__Homo_sapiens__NP_009117

<400>  2036

Met Glu Thr Arg Ser Pro Gly Leu Asn Asn Met Lys Pro Gln Ser Leu 
1               5                   10                  15      


Gln Leu Val Leu Glu Glu Gln Val Leu Ala Leu Gln Gln Gln Met Ala 
            20                  25                  30          


Glu Asn Gln Ala Ala Ser Trp Arg Lys Leu Lys Asn Ser Gln Glu Ala 
        35                  40                  45              


Gln Gln Arg Gln Ala Thr Leu Val Arg Lys Leu Gln Ala Lys Val Leu 
    50                  55                  60                  


Gln Tyr Arg Ser Trp Cys Gln Glu Leu Glu Lys Arg Leu Glu Ala Thr 
65                  70                  75                  80  


Gly Gly Pro Ile Pro Gln Arg Trp Glu Asn Val Glu Glu Pro Asn Leu 
                85                  90                  95      


Asp Glu Leu Leu Val Arg Leu Glu Glu Glu Gln Gln Arg Cys Glu Ser 
            100                 105                 110         


Leu Ala Glu Val Asn Thr Gln Leu Arg Leu His Met Glu Lys Ala Asp 
        115                 120                 125             


Val Val Asn Lys Ala Leu Arg Glu Asp Val Glu Lys Leu Thr Val Asp 
    130                 135                 140                 


Trp Ser Arg Ala Arg Asp Glu Leu Met Arg Lys Glu Ser Gln Trp Gln 
145                 150                 155                 160 


Met Glu Gln Glu Phe Phe Lys Gly Tyr Leu Lys Gly Glu His Gly Arg 
                165                 170                 175     


Leu Leu Ser Leu Trp Arg Glu Val Val Thr Phe Arg Arg His Phe Leu 
            180                 185                 190         


Glu Met Lys Ser Ala Thr Asp Arg Asp Leu Met Glu Leu Lys Ala Glu 
        195                 200                 205             


His Val Arg Leu Ser Gly Ser Leu Leu Thr Cys Cys Leu Arg Leu Thr 
    210                 215                 220                 


Val Gly Ala Gln Ser Arg Glu Pro Asn Gly Ser Gly Arg Met Asp Gly 
225                 230                 235                 240 


Arg Glu Pro Ala Gln Leu Leu Leu Leu Leu Ala Lys Thr Gln Glu Leu 
                245                 250                 255     


Glu Lys Glu Ala His Glu Arg Ser Gln Glu Leu Ile Gln Leu Lys Ser 
            260                 265                 270         


Gln Gly Asp Leu Glu Lys Ala Glu Leu Gln Asp Arg Val Thr Glu Leu 
        275                 280                 285             


Ser Ala Leu Leu Thr Gln Ser Gln Lys Gln Asn Glu Asp Tyr Glu Lys 
    290                 295                 300                 


Met Ile Lys Ala Leu Arg Glu Thr Val Glu Ile Leu Glu Thr Asn His 
305                 310                 315                 320 


Thr Glu Leu Met Glu His Glu Ala Ser Leu Ser Arg Asn Ala Gln Glu 
                325                 330                 335     


Glu Lys Leu Ser Leu Gln Gln Val Ile Lys Asp Ile Thr Gln Val Met 
            340                 345                 350         


Val Glu Glu Gly Asp Asn Ile Ala Gln Gly Ser Gly His Glu Asn Ser 
        355                 360                 365             


Leu Glu Leu Asp Ser Ser Ile Phe Ser Gln Phe Asp Tyr Gln Asp Ala 
    370                 375                 380                 


Asp Lys Ala Leu Thr Leu Val Arg Ser Val Leu Thr Arg Arg Arg Gln 
385                 390                 395                 400 


Ala Val Gln Asp Leu Arg Gln Gln Leu Ala Gly Cys Gln Glu Ala Val 
                405                 410                 415     


Asn Leu Leu Gln Gln Gln His Asp Gln Trp Glu Glu Glu Gly Lys Ala 
            420                 425                 430         


Leu Arg Gln Arg Leu Gln Lys Leu Thr Gly Glu Arg Asp Thr Leu Ala 
        435                 440                 445             


Gly Gln Thr Val Asp Leu Gln Gly Glu Val Asp Ser Leu Ser Lys Glu 
    450                 455                 460                 


Arg Glu Leu Leu Gln Lys Ala Arg Glu Glu Leu Arg Gln Gln Leu Glu 
465                 470                 475                 480 


Val Leu Glu Gln Glu Ala Trp Arg Leu Arg Arg Val Asn Val Glu Leu 
                485                 490                 495     


Gln Leu Gln Gly Asp Ser Ala Gln Gly Gln Lys Glu Glu Gln Gln Glu 
            500                 505                 510         


Glu Leu His Leu Ala Val Arg Glu Arg Glu Arg Leu Gln Glu Met Leu 
        515                 520                 525             


Met Gly Leu Glu Ala Lys Gln Ser Glu Ser Leu Ser Glu Leu Ile Thr 
    530                 535                 540                 


Leu Arg Glu Ala Leu Glu Ser Ser His Leu Glu Gly Glu Leu Leu Arg 
545                 550                 555                 560 


Gln Glu Gln Thr Glu Val Thr Ala Ala Leu Ala Arg Ala Glu Gln Ser 
                565                 570                 575     


Ile Ala Glu Leu Ser Ser Ser Glu Asn Thr Leu Lys Thr Glu Val Ala 
            580                 585                 590         


Asp Leu Arg Ala Ala Ala Val Lys Leu Ser Ala Leu Asn Glu Ala Leu 
        595                 600                 605             


Ala Leu Asp Lys Val Gly Leu Asn Gln Gln Leu Leu Gln Leu Glu Glu 
    610                 615                 620                 


Glu Asn Gln Ser Val Cys Ser Arg Met Glu Ala Ala Glu Gln Ala Arg 
625                 630                 635                 640 


Asn Ala Leu Gln Val Asp Leu Ala Glu Ala Glu Lys Arg Arg Glu Ala 
                645                 650                 655     


Leu Trp Glu Lys Asn Thr His Leu Glu Ala Gln Leu Gln Lys Ala Glu 
            660                 665                 670         


Glu Ala Gly Ala Glu Leu Gln Ala Asp Leu Arg Asp Ile Gln Glu Glu 
        675                 680                 685             


Lys Glu Glu Ile Gln Lys Lys Leu Ser Glu Ser Arg His Gln Gln Glu 
    690                 695                 700                 


Ala Ala Thr Thr Gln Leu Glu Gln Leu His Gln Glu Ala Lys Arg Gln 
705                 710                 715                 720 


Glu Glu Val Leu Ala Arg Ala Val Gln Glu Lys Glu Ala Leu Val Arg 
                725                 730                 735     


Glu Lys Ala Ala Leu Glu Val Arg Leu Gln Ala Val Glu Arg Asp Arg 
            740                 745                 750         


Gln Asp Leu Ala Glu Gln Leu Gln Gly Leu Ser Ser Ala Lys Glu Leu 
        755                 760                 765             


Leu Glu Ser Ser Leu Phe Glu Ala Gln Gln Gln Asn Ser Val Ile Glu 
    770                 775                 780                 


Val Thr Lys Gly Gln Leu Glu Val Gln Ile Gln Thr Val Thr Gln Ala 
785                 790                 795                 800 


Lys Glu Val Ile Gln Gly Glu Val Arg Cys Leu Lys Leu Glu Leu Asp 
                805                 810                 815     


Thr Glu Arg Ser Gln Ala Glu Gln Glu Arg Asp Ala Ala Ala Arg Gln 
            820                 825                 830         


Leu Ala Gln Ala Glu Gln Glu Gly Lys Thr Ala Leu Glu Gln Gln Lys 
        835                 840                 845             


Ala Ala His Glu Lys Glu Val Asn Gln Leu Arg Glu Lys Trp Glu Lys 
    850                 855                 860                 


Glu Arg Ser Trp His Gln Gln Glu Leu Ala Lys Ala Leu Glu Ser Leu 
865                 870                 875                 880 


Glu Arg Glu Lys Met Glu Leu Glu Met Arg Leu Lys Glu Gln Gln Thr 
                885                 890                 895     


Glu Met Glu Ala Ile Gln Ala Gln Arg Glu Glu Glu Arg Thr Gln Ala 
            900                 905                 910         


Glu Ser Ala Leu Cys Gln Met Gln Leu Glu Thr Glu Lys Glu Arg Val 
        915                 920                 925             


Ser Leu Leu Glu Thr Leu Leu Gln Thr Gln Lys Glu Leu Ala Asp Ala 
    930                 935                 940                 


Ser Gln Gln Leu Glu Arg Leu Arg Gln Asp Met Lys Val Gln Lys Leu 
945                 950                 955                 960 


Lys Glu Gln Glu Thr Thr Gly Ile Leu Gln Thr Gln Leu Gln Glu Ala 
                965                 970                 975     


Gln Arg Glu Leu Lys Glu Ala Ala Arg Gln His Arg Asp Asp Leu Ala 
            980                 985                 990         


Ala Leu Gln Glu Glu Ser Ser Ser  Leu Leu Gln Asp Lys  Met Asp Leu 
        995                 1000                 1005             


Gln Lys  Gln Val Glu Asp Leu  Lys Ser Gln Leu Val  Ala Gln Asp 
    1010                 1015                 1020             


Asp Ser  Gln Arg Leu Val Glu  Gln Glu Val Gln Glu  Lys Leu Arg 
    1025                 1030                 1035             


Glu Thr  Gln Glu Tyr Asn Arg  Ile Gln Lys Glu Leu  Glu Arg Glu 
    1040                 1045                 1050             


Lys Ala  Ser Leu Thr Leu Ser  Leu Met Glu Lys Glu  Gln Arg Leu 
    1055                 1060                 1065             


Leu Val  Leu Gln Glu Ala Asp  Ser Ile Arg Gln Gln  Glu Leu Ser 
    1070                 1075                 1080             


Ala Leu  Arg Gln Asp Met Gln  Glu Ala Gln Gly Glu  Gln Lys Glu 
    1085                 1090                 1095             


Leu Ser  Ala Gln Met Glu Leu  Leu Arg Gln Glu Val  Lys Glu Lys 
    1100                 1105                 1110             


Glu Ala  Asp Phe Leu Ala Gln  Glu Ala Gln Leu Leu  Glu Glu Leu 
    1115                 1120                 1125             


Glu Ala  Ser His Ile Thr Glu  Gln Gln Leu Arg Ala  Ser Leu Trp 
    1130                 1135                 1140             


Ala Gln  Glu Ala Lys Ala Ala  Gln Leu Gln Leu Arg  Leu Arg Ser 
    1145                 1150                 1155             


Thr Glu  Ser Gln Leu Glu Ala  Leu Ala Ala Glu Gln  Gln Pro Gly 
    1160                 1165                 1170             


Asn Gln  Ala Gln Ala Gln Ala  Gln Leu Ala Ser Leu  Tyr Ser Ala 
    1175                 1180                 1185             


Leu Gln  Gln Ala Leu Gly Ser  Val Cys Glu Ser Arg  Pro Glu Leu 
    1190                 1195                 1200             


Ser Gly  Gly Gly Asp Ser Ala  Pro Ser Val Trp Gly  Leu Glu Pro 
    1205                 1210                 1215             


Asp Gln  Asn Gly Ala Arg Ser  Leu Phe Lys Arg Gly  Pro Leu Leu 
    1220                 1225                 1230             


Thr Ala  Leu Ser Ala Glu Ala  Val Ala Ser Ala Leu  His Lys Leu 
    1235                 1240                 1245             


His Gln  Asp Leu Trp Lys Thr  Gln Gln Thr Arg Asp  Val Leu Arg 
    1250                 1255                 1260             


Asp Gln  Val Gln Lys Leu Glu  Glu Arg Leu Thr Asp  Thr Glu Ala 
    1265                 1270                 1275             


Glu Lys  Ser Gln Val His Thr  Glu Leu Gln Asp Leu  Gln Arg Gln 
    1280                 1285                 1290             


Leu Ser  Gln Asn Gln Glu Glu  Lys Ser Lys Trp Glu  Gly Lys Gln 
    1295                 1300                 1305             


Asn Ser  Leu Glu Ser Glu Leu  Met Glu Leu His Glu  Thr Met Ala 
    1310                 1315                 1320             


Ser Leu  Gln Ser Arg Leu Arg  Arg Ala Glu Leu Gln  Arg Met Glu 
    1325                 1330                 1335             


Ala Gln  Gly Glu Arg Glu Leu  Leu Gln Ala Ala Lys  Glu Asn Leu 
    1340                 1345                 1350             


Thr Ala  Gln Val Glu His Leu  Gln Ala Ala Val Val  Glu Ala Arg 
    1355                 1360                 1365             


Ala Gln  Ala Ser Ala Ala Gly  Ile Leu Glu Glu Asp  Leu Arg Thr 
    1370                 1375                 1380             


Ala Arg  Ser Ala Leu Lys Leu  Lys Asn Glu Glu Val  Glu Ser Glu 
    1385                 1390                 1395             


Arg Glu  Arg Ala Gln Ala Leu  Gln Glu Gln Gly Glu  Leu Lys Val 
    1400                 1405                 1410             


Ala Gln  Gly Lys Ala Leu Gln  Glu Asn Leu Ala Leu  Leu Thr Gln 
    1415                 1420                 1425             


Thr Leu  Ala Glu Arg Glu Glu  Glu Val Glu Thr Leu  Arg Gly Gln 
    1430                 1435                 1440             


Ile Gln  Glu Leu Glu Lys Gln  Arg Glu Met Gln Lys  Ala Ala Leu 
    1445                 1450                 1455             


Glu Leu  Leu Ser Leu Asp Leu  Lys Lys Arg Asn Gln  Glu Val Asp 
    1460                 1465                 1470             


Leu Gln  Gln Glu Gln Ile Gln  Glu Leu Glu Lys Cys  Arg Ser Val 
    1475                 1480                 1485             


Leu Glu  His Leu Pro Met Ala  Val Gln Glu Arg Glu  Gln Lys Leu 
    1490                 1495                 1500             


Thr Val  Gln Arg Glu Gln Ile  Arg Glu Leu Glu Lys  Asp Arg Glu 
    1505                 1510                 1515             


Thr Gln  Arg Asn Val Leu Glu  His Gln Leu Leu Glu  Leu Glu Lys 
    1520                 1525                 1530             


Lys Asp  Gln Met Ile Glu Ser  Gln Arg Gly Gln Val  Gln Asp Leu 
    1535                 1540                 1545             


Lys Lys  Gln Leu Val Thr Leu  Glu Cys Leu Ala Leu  Glu Leu Glu 
    1550                 1555                 1560             


Glu Asn  His His Lys Met Glu  Cys Gln Gln Lys Leu  Ile Lys Glu 
    1565                 1570                 1575             


Leu Glu  Gly Gln Arg Glu Thr  Gln Arg Val Ala Leu  Thr His Leu 
    1580                 1585                 1590             


Thr Leu  Asp Leu Glu Glu Arg  Ser Gln Glu Leu Gln  Ala Gln Ser 
    1595                 1600                 1605             


Ser Gln  Ile His Asp Leu Glu  Ser His Ser Thr Val  Leu Ala Arg 
    1610                 1615                 1620             


Glu Leu  Gln Glu Arg Asp Gln  Glu Val Lys Ser Gln  Arg Glu Gln 
    1625                 1630                 1635             


Ile Glu  Glu Leu Gln Arg Gln  Lys Glu His Leu Thr  Gln Asp Leu 
    1640                 1645                 1650             


Glu Arg  Arg Asp Gln Glu Leu  Met Leu Gln Lys Glu  Arg Ile Gln 
    1655                 1660                 1665             


Val Leu  Glu Asp Gln Arg Thr  Arg Gln Thr Lys Ile  Leu Glu Glu 
    1670                 1675                 1680             


Asp Leu  Glu Gln Ile Lys Leu  Ser Leu Arg Glu Arg  Gly Arg Glu 
    1685                 1690                 1695             


Leu Thr  Thr Gln Arg Gln Leu  Met Gln Glu Arg Ala  Glu Glu Gly 
    1700                 1705                 1710             


Lys Gly  Pro Ser Lys Ala Gln  Arg Gly Ser Leu Glu  His Met Lys 
    1715                 1720                 1725             


Leu Ile  Leu Arg Asp Lys Glu  Lys Glu Val Glu Cys  Gln Gln Glu 
    1730                 1735                 1740             


His Ile  His Glu Leu Gln Glu  Leu Lys Asp Gln Leu  Glu Gln Gln 
    1745                 1750                 1755             


Leu Gln  Gly Leu His Arg Lys  Val Gly Glu Thr Ser  Leu Leu Leu 
    1760                 1765                 1770             


Ser Gln  Arg Glu Gln Glu Ile  Val Val Leu Gln Gln  Gln Leu Gln 
    1775                 1780                 1785             


Glu Ala  Arg Glu Gln Gly Glu  Leu Lys Glu Gln Ser  Leu Gln Ser 
    1790                 1795                 1800             


Gln Leu  Asp Glu Ala Gln Arg  Ala Leu Ala Gln Arg  Asp Gln Glu 
    1805                 1810                 1815             


Leu Glu  Ala Leu Gln Gln Glu  Gln Gln Gln Ala Gln  Gly Gln Glu 
    1820                 1825                 1830             


Glu Arg  Val Lys Glu Lys Ala  Asp Ala Leu Gln Gly  Ala Leu Glu 
    1835                 1840                 1845             


Gln Ala  His Met Thr Leu Lys  Glu Arg His Gly Glu  Leu Gln Asp 
    1850                 1855                 1860             


His Lys  Glu Gln Ala Arg Arg  Leu Glu Glu Glu Leu  Ala Val Glu 
    1865                 1870                 1875             


Gly Arg  Arg Val Gln Ala Leu  Glu Glu Val Leu Gly  Asp Leu Arg 
    1880                 1885                 1890             


Ala Glu  Ser Arg Glu Gln Glu  Lys Ala Leu Leu Ala  Leu Gln Gln 
    1895                 1900                 1905             


Gln Cys  Ala Glu Gln Ala Gln  Glu His Glu Val Glu  Thr Arg Ala 
    1910                 1915                 1920             


Leu Gln  Asp Ser Trp Leu Gln  Ala Gln Ala Val Leu  Lys Glu Arg 
    1925                 1930                 1935             


Asp Gln  Glu Leu Glu Ala Leu  Arg Ala Glu Ser Gln  Ser Ser Arg 
    1940                 1945                 1950             


His Gln  Glu Glu Ala Ala Arg  Ala Arg Ala Glu Ala  Leu Gln Glu 
    1955                 1960                 1965             


Ala Leu  Gly Lys Ala His Ala  Ala Leu Gln Gly Lys  Glu Gln His 
    1970                 1975                 1980             


Leu Leu  Glu Gln Ala Glu Leu  Ser Arg Ser Leu Glu  Ala Ser Thr 
    1985                 1990                 1995             


Ala Thr  Leu Gln Ala Ser Leu  Asp Ala Cys Gln Ala  His Ser Arg 
    2000                 2005                 2010             


Gln Leu  Glu Glu Ala Leu Arg  Ile Gln Glu Gly Glu  Ile Gln Asp 
    2015                 2020                 2025             


Gln Asp  Leu Arg Tyr Gln Glu  Asp Val Gln Gln Leu  Gln Gln Ala 
    2030                 2035                 2040             


Leu Ala  Gln Arg Asp Glu Glu  Leu Arg His Gln Gln  Glu Arg Glu 
    2045                 2050                 2055             


Gln Leu  Leu Glu Lys Ser Leu  Ala Gln Arg Val Gln  Glu Asn Met 
    2060                 2065                 2070             


Ile Gln  Glu Lys Gln Asn Leu  Gly Gln Glu Arg Glu  Glu Glu Glu 
    2075                 2080                 2085             


Ile Arg  Gly Leu His Gln Ser  Val Arg Glu Leu Gln  Leu Thr Leu 
    2090                 2095                 2100             


Ala Gln  Lys Glu Gln Glu Ile  Leu Glu Leu Arg Glu  Thr Gln Gln 
    2105                 2110                 2115             


Arg Asn  Asn Leu Glu Ala Leu  Pro His Ser His Lys  Thr Ser Pro 
    2120                 2125                 2130             


Met Glu  Glu Gln Ser Leu Lys  Leu Asp Ser Leu Glu  Pro Arg Leu 
    2135                 2140                 2145             


Gln Arg  Glu Leu Glu Arg Leu  Gln Ala Ala Leu Arg  Gln Thr Glu 
    2150                 2155                 2160             


Ala Arg  Glu Ile Glu Trp Arg  Glu Lys Ala Gln Asp  Leu Ala Leu 
    2165                 2170                 2175             


Ser Leu  Ala Gln Thr Lys Ala  Ser Val Ser Ser Leu  Gln Glu Val 
    2180                 2185                 2190             


Ala Met  Phe Leu Gln Ala Ser  Val Leu Glu Arg Asp  Ser Glu Gln 
    2195                 2200                 2205             


Gln Arg  Leu Gln Asp Glu Leu  Glu Leu Thr Arg Arg  Ala Leu Glu 
    2210                 2215                 2220             


Lys Glu  Arg Leu His Ser Pro  Gly Ala Thr Ser Thr  Ala Glu Leu 
    2225                 2230                 2235             


Gly Ser  Arg Gly Glu Gln Gly  Val Gln Leu Gly Glu  Val Ser Gly 
    2240                 2245                 2250             


Val Glu  Ala Glu Pro Ser Pro  Asp Gly Met Glu Lys  Gln Ser Trp 
    2255                 2260                 2265             


Arg Gln  Arg Leu Glu His Leu  Gln Gln Ala Val Ala  Arg Leu Glu 
    2270                 2275                 2280             


Ile Asp  Arg Ser Arg Leu Gln  Arg His Asn Val Gln  Leu Arg Ser 
    2285                 2290                 2295             


Thr Leu  Glu Gln Val Glu Arg  Glu Arg Arg Lys Leu  Lys Arg Glu 
    2300                 2305                 2310             


Ala Met  Arg Ala Ala Gln Ala  Gly Ser Leu Glu Ile  Ser Lys Ala 
    2315                 2320                 2325             


Thr Ala  Ser Ser Pro Thr Gln  Gln Asp Gly Arg Gly  Gln Lys Asn 
    2330                 2335                 2340             


Ser Asp  Ala Lys Cys Val Ala  Glu Leu Gln Lys Glu  Val Val Leu 
    2345                 2350                 2355             


Leu Gln  Ala Gln Leu Thr Leu  Glu Arg Lys Gln Lys  Gln Asp Tyr 
    2360                 2365                 2370             


Ile Thr  Arg Ser Ala Gln Thr  Ser Arg Glu Leu Ala  Gly Leu His 
    2375                 2380                 2385             


His Ser  Leu Ser His Ser Leu  Leu Ala Val Ala Gln  Ala Pro Glu 
    2390                 2395                 2400             


Ala Thr  Val Leu Glu Ala Glu  Thr Arg Arg Leu Asp  Glu Ser Leu 
    2405                 2410                 2415             


Thr Gln  Ser Leu Thr Ser Pro  Gly Pro Val Leu Leu  His Pro Ser 
    2420                 2425                 2430             


Pro Ser  Thr Thr Gln Ala Ala  Ser Arg 
    2435                 2440         


<210>  2037
<211>  2479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP290__Homo_sapiens__NP_079390

<400>  2037

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  2038
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP41__Homo_sapiens__NP_001244087

<400>  2038

Met Ser Leu Arg Arg His Ile Gly Asn Pro Glu Tyr Leu Met Lys Arg 
1               5                   10                  15      


Ile Pro Gln Asn Pro Arg Tyr Gln His Ile Lys Ser Arg Leu Asp Thr 
            20                  25                  30          


Gly Asn Ser Met Thr Lys Tyr Thr Glu Lys Leu Glu Glu Ile Lys Lys 
        35                  40                  45              


Asn Tyr Arg Tyr Lys Lys Asp Glu Leu Phe Lys Arg Leu Lys Val Thr 
    50                  55                  60                  


Thr Phe Ala Gln Leu Ile Ile Gln Val Ala Ser Leu Ser Asp Gln Thr 
65                  70                  75                  80  


Leu Glu Val Thr Ala Glu Glu Ile Gln Arg Leu Glu Asp Asn Asp Ser 
                85                  90                  95      


Ala Ala Ser Asp Pro Asp Ala Glu Thr Thr Ala Arg Thr Asn Gly Lys 
            100                 105                 110         


Gly Asn Pro Gly Glu Gln Ser Pro Ser Pro Glu Gln Phe Ile Asn Asn 
        115                 120                 125             


Ala Gly Ala Gly Asp Ser Ser Arg Ser Thr Leu Gln Ser Val Ile Ser 
    130                 135                 140                 


Gly Val Gly Glu Leu Asp Leu Asp Lys Gly Pro Val Lys Lys Ala Glu 
145                 150                 155                 160 


Pro His Thr Lys Asp Lys Pro Tyr Pro Asp Cys Pro Phe Leu Leu Leu 
                165                 170                 175     


Asp Val Arg Asp Arg Asp Ser Tyr Gln Gln Cys His Ile Val Gly Ala 
            180                 185                 190         


Tyr Ser Tyr Pro Ile Ala Thr Leu Ser Arg Thr Met Asn Pro Tyr Ser 
        195                 200                 205             


Asn Asp Ile Leu Glu Tyr Lys Asn Ala His Gly Lys Ile Ile Ile Leu 
    210                 215                 220                 


Tyr Asp Asp Asp Glu Arg Leu Ala Ser Gln Ala Ala Thr Thr Met Cys 
225                 230                 235                 240 


Glu Arg Gly Phe Glu Asn Leu Phe Met Leu Ser Gly Gly Arg Leu Asn 
                245                 250                 255     


Gln Ala Asn Ser Ser Gly Arg Glu Ser Lys Val Pro Gly Ala Arg Ser 
            260                 265                 270         


Ala Gln Asn Leu Pro Gly Gly Gly Pro Ala Ser His Ser Asn Pro Arg 
        275                 280                 285             


Ser Leu Ser Ser Gly His Leu Gln Gly Lys Pro Trp Lys 
    290                 295                 300     


<210>  2039
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP55__Homo_sapiens__NP_001120654

<400>  2039

Met Ser Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser 
1               5                   10                  15      


Lys Pro Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly 
            20                  25                  30          


Glu Ile Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys 
        35                  40                  45              


Gly Lys Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg 
    50                  55                  60                  


Val Leu Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys 
65                  70                  75                  80  


Asp Lys Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser 
                85                  90                  95      


Thr Thr Ala Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu 
            100                 105                 110         


Arg Arg Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu 
        115                 120                 125             


Lys Gln Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser 
    130                 135                 140                 


Lys Thr Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe 
145                 150                 155                 160 


Asn Ser Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp 
                165                 170                 175     


Ala Leu Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu 
            180                 185                 190         


Val Tyr Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys 
        195                 200                 205             


Thr Glu Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu 
    210                 215                 220                 


Ser Glu Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu 
225                 230                 235                 240 


Leu Ala Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr 
                245                 250                 255     


Gln Leu Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr 
            260                 265                 270         


Gln Lys Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg 
        275                 280                 285             


Ala Asp Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile 
    290                 295                 300                 


Gln Lys Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu 
305                 310                 315                 320 


Glu Lys Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr 
                325                 330                 335     


Thr Ser Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu 
            340                 345                 350         


Glu Gln Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu 
        355                 360                 365             


Asp Arg Gln His Val Gln His Gln Leu His Val Ile Leu Lys Glu Leu 
    370                 375                 380                 


Arg Lys Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu 
385                 390                 395                 400 


His Glu Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr 
                405                 410                 415     


Glu Asn Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala 
            420                 425                 430         


Leu Asn Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro 
        435                 440                 445             


Ala Thr Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys 
    450                 455                 460                 


<210>  2040
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP57__Homo_sapiens__NP_001230705

<400>  2040

Met Leu Thr Arg Ile Asp Asn Ser Phe Ala Glu Pro Ser Arg Ser Asn 
1               5                   10                  15      


Gly Ser Met Val Arg His Ser Ser Ser Pro Tyr Val Val Tyr Pro Ser 
            20                  25                  30          


Asp Lys Pro Phe Leu Asn Ser Asp Leu Arg Arg Ser Pro Ser Lys Pro 
        35                  40                  45              


Thr Leu Ala Tyr Pro Glu Ser Asn Ser Arg Ala Ile Phe Ser Ala Leu 
    50                  55                  60                  


Lys Asn Leu Gln Asp Lys Ile Arg Arg Leu Glu Leu Glu Arg Ile Gln 
65                  70                  75                  80  


Ala Glu Glu Ser Val Lys Thr Leu Ser Arg Glu Thr Ile Glu Tyr Lys 
                85                  90                  95      


Lys Val Leu Asp Glu Gln Ile Gln Glu Arg Glu Asn Ser Lys Asn Glu 
            100                 105                 110         


Glu Ser Lys His Asn Gln Glu Leu Thr Ser Gln Leu Leu Ala Ala Glu 
        115                 120                 125             


Asn Lys Cys Asn Leu Leu Glu Lys Gln Leu Glu Tyr Met Arg Asn Met 
    130                 135                 140                 


Ile Lys His Ala Glu Met Glu Arg Thr Ser Val Leu Glu Lys Gln Val 
145                 150                 155                 160 


Ser Leu Glu Arg Glu Arg Gln His Asp Gln Thr His Val Gln Ser Gln 
                165                 170                 175     


Leu Glu Lys Leu Asp Leu Leu Glu Gln Glu Tyr Asn Lys Leu Thr Thr 
            180                 185                 190         


Met Gln Ala Leu Ala Glu Lys Lys Met Gln Glu Leu Glu Ala Lys Leu 
        195                 200                 205             


His Glu Glu Glu Gln Glu Arg Lys Arg Met Gln Ala Lys Ala Ala Glu 
    210                 215                 220                 


Leu Gln Thr Gly Leu Glu Thr Asn Arg Leu Ile Phe Glu Asp Lys Ala 
225                 230                 235                 240 


Thr Pro Cys Val Pro Asn Ala Arg Arg Ile Lys Lys Lys Lys Ser Lys 
                245                 250                 255     


Pro Pro Glu Lys Lys Ser Ser Arg Asn Tyr Phe Gly Ala Gln Pro His 
            260                 265                 270         


Tyr Arg Leu Cys Leu Gly Asp Met Pro Phe Val Ala Gly Lys Ser Thr 
        275                 280                 285             


Ser Pro Ser His Ala Val Val Ala Asn Val Gln Leu Val Leu His Leu 
    290                 295                 300                 


Met Lys Gln His Ser Lys Ala Leu Cys Asn Asp Arg Val Ile Asn Ser 
305                 310                 315                 320 


Ile Pro Leu Ala Lys Gln Val Ser Ser Arg Gly Gly Lys Ser Lys Lys 
                325                 330                 335     


Leu Ser Val Thr Pro Pro Ser Ser Asn Gly Ile Asn Glu Glu Leu Ser 
            340                 345                 350         


Glu Val Leu Gln Thr Leu Gln Asp Glu Phe Gly Gln Met Ser Phe Asp 
        355                 360                 365             


His Gln Gln Leu Ala Lys Leu Ile Gln Glu Ser Pro Thr Val Glu Leu 
    370                 375                 380                 


Lys Asp Lys Leu Glu Cys Glu Leu Glu Ala Leu Val Gly Arg Met Glu 
385                 390                 395                 400 


Ala Lys Ala Asn Gln Ile Thr Lys Val Arg Lys Tyr Gln Ala Gln Leu 
                405                 410                 415     


Glu Lys Gln Lys Leu Glu Lys Gln Lys Lys Glu Leu Lys Ala Thr Lys 
            420                 425                 430         


Lys Thr Leu Asp Glu Glu Arg Asn Ser Ser Ser Arg Ser Gly Ile Thr 
        435                 440                 445             


Gly Thr Thr Asn Lys Lys Asp Phe Met Lys Leu Arg Pro Gly Glu Lys 
    450                 455                 460                 


Arg Arg Lys Asn Leu Gln Leu Leu Lys Asp Met Gln Ser Ile Gln Asn 
465                 470                 475                 480 


Ser Leu Gln Ser Ser Ser Leu Cys Trp Asp Tyr 
                485                 490     


<210>  2041
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP63__Homo_sapiens__NP_001035842

<400>  2041

Met Glu Ala Leu Leu Glu Gly Ile Gln Asn Arg Gly His Gly Gly Gly 
1               5                   10                  15      


Phe Leu Thr Ser Cys Glu Ala Glu Leu Gln Glu Leu Met Lys Gln Ile 
            20                  25                  30          


Asp Ile Met Val Ala His Lys Lys Ser Glu Trp Glu Gly Arg Thr His 
        35                  40                  45              


Ala Leu Glu Thr Cys Leu Lys Ile Arg Glu Gln Glu Leu Lys Ser Leu 
    50                  55                  60                  


Arg Ser Gln Leu Asp Val Thr His Lys Glu Val Gly Met Leu His Gln 
65                  70                  75                  80  


Gln Val Glu Glu His Glu Lys Ile Lys Gln Glu Met Thr Met Glu Tyr 
                85                  90                  95      


Lys Gln Glu Leu Lys Lys Leu His Glu Glu Leu Cys Ile Leu Lys Arg 
            100                 105                 110         


Ser Tyr Glu Lys Leu Gln Lys Lys Gln Met Arg Glu Phe Arg Gly Asn 
        115                 120                 125             


Thr Lys Asn His Arg Glu Asp Arg Ser Glu Ile Glu Arg Leu Thr Ala 
    130                 135                 140                 


Lys Ile Glu Glu Phe Arg Gln Lys Ser Leu Asp Trp Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Ile Tyr Gln Gln Gln Val Ser Ser Leu Glu Ala Gln Arg Lys Ala 
                165                 170                 175     


Leu Ala Glu Gln Ser Glu Ile Ile Gln Ala Gln Leu Val Asn Arg Lys 
            180                 185                 190         


Gln Lys Leu Glu Ser Val Glu Leu Ser Ser Gln Ser Glu Ile Gln His 
        195                 200                 205             


Leu Ser Ser Lys Leu Glu Arg Ala Asn Asp Thr Ile Cys Ala Asn Glu 
    210                 215                 220                 


Leu Glu Ile Glu Arg Leu Thr Met Arg Val Asn Asp Leu Val Gly Thr 
225                 230                 235                 240 


Ser Met Thr Val Leu Gln Glu Gln Gln Gln Lys Glu Glu Lys Leu Arg 
                245                 250                 255     


Glu Ser Glu Lys Leu Leu Glu Ala Leu Gln Glu Glu Lys Arg Glu Leu 
            260                 265                 270         


Lys Ala Ala Leu Gln Ser Gln Glu Asn Leu Ile His Glu Ala Arg Ile 
        275                 280                 285             


Gln Lys Glu Lys Leu Gln Glu Lys Val Lys Ala Thr Asn Thr Gln His 
    290                 295                 300                 


Ala Val Glu Ala Ile Ser Leu Glu Ser Val Ser Ala Thr Cys Lys Gln 
305                 310                 315                 320 


Leu Ser Gln Glu Leu Met Glu Lys Tyr Glu Glu Leu Lys Arg Met Glu 
                325                 330                 335     


Ala His Asn Asn Glu Tyr Lys Ala Glu Ile Lys Lys Leu Lys Glu Gln 
            340                 345                 350         


Ile Leu Gln Gly Glu Gln Ser Tyr Ser Ser Ala Leu Glu Gly Met Lys 
        355                 360                 365             


Met Glu Ile Ser His Leu Thr Gln Glu Leu His Gln Arg Asp Ile Thr 
    370                 375                 380                 


Ile Ala Ser Thr Lys Gly Ser Ser Ser Asp Met Glu Lys Arg Leu Arg 
385                 390                 395                 400 


Ala Glu Met Gln Lys Ala Glu Asp Lys Ala Val Glu His Lys Glu Ile 
                405                 410                 415     


Leu Asp Gln Leu Glu Ser Leu Lys Leu Glu Asn Arg His Leu Ser Glu 
            420                 425                 430         


Met Val Met Lys Leu Glu Leu Gly Leu His Glu Cys Ser Leu Pro Val 
        435                 440                 445             


Ser Pro Leu Gly Ser Ile Ala Thr Arg Phe Leu Glu Glu Glu Glu Leu 
    450                 455                 460                 


Arg Ser His His Ile Leu Glu Arg Leu Asp Ala His Ile Glu Glu Leu 
465                 470                 475                 480 


Lys Arg Glu Ser Glu Lys Thr Val Arg Gln Phe Thr Ala Leu Lys 
                485                 490                 495 


<210>  2042
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP68__Homo_sapiens__NP_055962

<400>  2042

Met Ala Leu Gly Glu Glu Lys Ala Glu Ala Glu Ala Ser Glu Asp Thr 
1               5                   10                  15      


Lys Ala Gln Ser Tyr Gly Arg Gly Ser Cys Arg Glu Arg Glu Leu Asp 
            20                  25                  30          


Ile Pro Gly Pro Met Ser Gly Glu Gln Pro Pro Arg Leu Glu Ala Glu 
        35                  40                  45              


Gly Gly Leu Ile Ser Pro Val Trp Gly Ala Glu Gly Ile Pro Ala Pro 
    50                  55                  60                  


Thr Cys Trp Ile Gly Thr Asp Pro Gly Gly Pro Ser Arg Ala His Gln 
65                  70                  75                  80  


Pro Gln Ala Ser Asp Ala Asn Arg Glu Pro Val Ala Glu Arg Ser Glu 
                85                  90                  95      


Pro Ala Leu Ser Gly Leu Pro Pro Ala Thr Met Gly Ser Gly Asp Leu 
            100                 105                 110         


Leu Leu Ser Gly Glu Ser Gln Val Glu Lys Thr Lys Leu Ser Ser Ser 
        115                 120                 125             


Glu Glu Phe Pro Gln Thr Leu Ser Leu Pro Arg Thr Thr Thr Ile Cys 
    130                 135                 140                 


Ser Gly His Asp Ala Asp Thr Glu Asp Asp Pro Ser Leu Ala Asp Leu 
145                 150                 155                 160 


Pro Gln Ala Leu Asp Leu Ser Gln Gln Pro His Ser Ser Gly Leu Ser 
                165                 170                 175     


Cys Leu Ser Gln Trp Lys Ser Val Leu Ser Pro Gly Ser Ala Ala Gln 
            180                 185                 190         


Pro Ser Ser Cys Ser Ile Ser Ala Ser Ser Thr Gly Ser Ser Leu Gln 
        195                 200                 205             


Gly His Gln Glu Arg Ala Glu Pro Arg Gly Gly Ser Leu Ala Lys Val 
    210                 215                 220                 


Ser Ser Ser Leu Glu Pro Val Val Pro Gln Glu Pro Ser Ser Val Val 
225                 230                 235                 240 


Gly Leu Gly Pro Arg Pro Gln Trp Ser Pro Gln Pro Val Phe Ser Gly 
                245                 250                 255     


Gly Asp Ala Ser Gly Leu Gly Arg Arg Arg Leu Ser Phe Gln Ala Glu 
            260                 265                 270         


Tyr Trp Ala Cys Val Leu Pro Asp Ser Leu Pro Pro Ser Pro Asp Arg 
        275                 280                 285             


His Ser Pro Leu Trp Asn Pro Asn Lys Glu Tyr Glu Asp Leu Leu Asp 
    290                 295                 300                 


Tyr Thr Tyr Pro Leu Arg Pro Gly Pro Gln Leu Pro Lys His Leu Asp 
305                 310                 315                 320 


Ser Arg Val Pro Ala Asp Pro Val Leu Gln Asp Ser Gly Val Asp Leu 
                325                 330                 335     


Asp Ser Phe Ser Val Ser Pro Ala Ser Thr Leu Lys Ser Pro Thr Asn 
            340                 345                 350         


Val Ser Pro Asn Cys Pro Pro Ala Glu Ala Thr Ala Leu Pro Phe Ser 
        355                 360                 365             


Gly Pro Arg Glu Pro Ser Leu Lys Gln Trp Pro Ser Arg Val Pro Gln 
    370                 375                 380                 


Lys Gln Gly Gly Met Gly Leu Ala Ser Trp Ser Gln Leu Ala Ser Thr 
385                 390                 395                 400 


Pro Arg Ala Pro Gly Ser Arg Asp Ala Arg Trp Glu Arg Arg Glu Pro 
                405                 410                 415     


Ala Leu Arg Gly Ala Lys Asp Arg Leu Thr Ile Gly Lys His Leu Asp 
            420                 425                 430         


Met Gly Ser Pro Gln Leu Arg Thr Arg Asp Arg Gly Trp Pro Ser Pro 
        435                 440                 445             


Arg Pro Glu Arg Glu Lys Arg Thr Ser Gln Ser Ala Arg Arg Pro Thr 
    450                 455                 460                 


Cys Thr Glu Ser Arg Trp Lys Ser Glu Glu Glu Val Glu Ser Asp Asp 
465                 470                 475                 480 


Glu Tyr Leu Ala Leu Pro Ala Arg Leu Thr Gln Val Ser Ser Leu Val 
                485                 490                 495     


Ser Tyr Leu Gly Ser Ile Ser Thr Leu Val Thr Leu Pro Thr Gly Asp 
            500                 505                 510         


Ile Lys Gly Gln Ser Pro Leu Glu Val Ser Asp Ser Asp Gly Pro Ala 
        515                 520                 525             


Ser Phe Pro Ser Ser Ser Ser Gln Ser Gln Leu Pro Pro Gly Ala Ala 
    530                 535                 540                 


Leu Gln Gly Ser Gly Asp Pro Glu Gly Gln Asn Pro Cys Phe Leu Arg 
545                 550                 555                 560 


Ser Phe Val Arg Ala His Asp Ser Ala Gly Glu Gly Ser Leu Gly Ser 
                565                 570                 575     


Ser Gln Ala Leu Gly Val Ser Ser Gly Leu Leu Lys Thr Arg Pro Ser 
            580                 585                 590         


Leu Pro Ala Arg Leu Asp Arg Trp Pro Phe Ser Asp Pro Asp Val Glu 
        595                 600                 605             


Gly Gln Leu Pro Arg Lys Gly Gly Glu Gln Gly Lys Glu Ser Leu Val 
    610                 615                 620                 


Gln Cys Val Lys Thr Phe Cys Cys Gln Leu Glu Glu Leu Ile Cys Trp 
625                 630                 635                 640 


Leu Tyr Asn Val Ala Asp Val Thr Asp His Gly Thr Ala Ala Arg Ser 
                645                 650                 655     


Asn Leu Thr Ser Leu Lys Ser Ser Leu Gln Leu Tyr Arg Gln Phe Lys 
            660                 665                 670         


Lys Asp Ile Asp Glu His Gln Ser Leu Thr Glu Ser Val Leu Gln Lys 
        675                 680                 685             


Gly Glu Ile Leu Leu Gln Cys Leu Leu Glu Asn Thr Pro Val Leu Glu 
    690                 695                 700                 


Asp Val Leu Gly Arg Ile Ala Lys Gln Ser Gly Glu Leu Glu Ser His 
705                 710                 715                 720 


Ala Asp Arg Leu Tyr Asp Ser Ile Leu Ala Ser Leu Asp Met Leu Ala 
                725                 730                 735     


Gly Cys Thr Leu Ile Pro Asp Lys Lys Pro Met Ala Ala Met Glu His 
            740                 745                 750         


Pro Cys Glu Gly Val 
        755         


<210>  2043
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP72__Homo_sapiens__NP_060610

<400>  2043

Met Ala Arg Ala Gly Pro Arg Leu Val Leu Ser Glu Glu Ala Val Arg 
1               5                   10                  15      


Ala Lys Ser Gly Leu Gly Pro His Arg Asp Leu Ala Glu Leu Gln Ser 
            20                  25                  30          


Leu Ser Ile Pro Gly Thr Tyr Gln Glu Lys Ile Thr His Leu Gly His 
        35                  40                  45              


Ser Leu Met Ser Leu Thr Gly Leu Lys Ser Leu Asp Leu Ser Arg Asn 
    50                  55                  60                  


Ser Leu Val Ser Leu Glu Gly Ile Gln Tyr Leu Thr Ala Leu Glu Ser 
65                  70                  75                  80  


Leu Asn Leu Tyr Tyr Asn Cys Ile Ser Ser Leu Ala Glu Val Phe Arg 
                85                  90                  95      


Leu His Ala Leu Thr Glu Leu Val Asp Val Asp Phe Arg Leu Asn Pro 
            100                 105                 110         


Val Val Lys Val Glu Pro Asp Tyr Arg Leu Phe Val Val His Leu Leu 
        115                 120                 125             


Pro Lys Leu Gln Gln Leu Asp Asp Arg Pro Val Arg Ala Ser Glu Arg 
    130                 135                 140                 


Lys Ala Ser Arg Leu His Phe Ala Ser Glu Asp Ser Leu Asp Ser Lys 
145                 150                 155                 160 


Glu Ser Val Pro Ala Ser Leu Lys Glu Gly Arg Pro His His Pro Arg 
                165                 170                 175     


Ala Lys Cys Thr Glu Ala Leu Ala Lys Gln Ser Leu Val Met Asp Ala 
            180                 185                 190         


Asp Asp Glu Ala Val Leu Asn Leu Ile Ala Glu Cys Glu Trp Asp Leu 
        195                 200                 205             


Gly Arg Pro Pro Gly Ser Thr Ser Phe Ser Gln Lys Gly Arg Glu Ala 
    210                 215                 220                 


Asp Ser Arg Gly Ser Gln Glu Ser Arg His Leu Leu Ser Pro Gln Leu 
225                 230                 235                 240 


Val Gln Tyr Gln Cys Gly Asp Ser Gly Lys Gln Gly Arg Glu Thr Arg 
                245                 250                 255     


Arg Ser Ser Cys Arg Gly Cys Cys Leu Glu Lys Met Pro Trp Ser Gln 
            260                 265                 270         


Leu Cys Gly Glu Leu Pro Pro Leu Tyr Gly Ala Glu Pro Glu Ala Ser 
        275                 280                 285             


Arg Ala Pro Arg Pro His Thr Tyr Phe Thr Pro His Pro Asp Ser Met 
    290                 295                 300                 


Asp Thr Glu Asp Ser Ala Ser Ser Gln Lys Leu Asp Leu Ser Gly Glu 
305                 310                 315                 320 


Met Val Pro Gly Pro Leu Pro Ala Pro Gly Lys Cys Arg Lys Arg Arg 
                325                 330                 335     


Met Pro Val Gly Arg Phe Gln Thr Phe Ser Asp Gln Glu Gly Leu Gly 
            340                 345                 350         


Cys Pro Glu Arg Thr His Gly Ser Ser Val Pro Lys Glu Ser Leu Ser 
        355                 360                 365             


Arg Gln Asp Ser Ser Glu Ser Arg Asn Gly Arg Thr Leu Ser Gln Pro 
    370                 375                 380                 


Glu Ala Ser Glu Thr Glu Glu Gln Arg Ser Arg Gly Val Thr Asp Thr 
385                 390                 395                 400 


Arg Glu Pro Ser Pro Gly Ser His Ser Ala Leu Pro Gly Lys Lys Thr 
                405                 410                 415     


Ala Leu Gln Ala Ala Leu Leu Glu Thr Leu Leu Asp Leu Val Asp Arg 
            420                 425                 430         


Ser Trp Gly Gly Cys Arg Ser Leu His Ser Asn Glu Ala Phe Leu Ala 
        435                 440                 445             


Gln Ala Arg His Ile Leu Ser Ser Val Glu Glu Phe Thr Ala Ala Gln 
    450                 455                 460                 


Asp Ser Ser Ala Met Val Gly Glu Asp Val Gly Ser Leu Ala Leu Glu 
465                 470                 475                 480 


Ser Lys Ser Leu Gln Ser Arg Leu Ala Glu Gln Gln Gln Gln His Ala 
                485                 490                 495     


Arg Glu Met Ser Glu Val Thr Ala Glu Leu His His Thr His Lys Glu 
            500                 505                 510         


Leu Asp Asp Leu Arg Gln His Leu Asp Lys Ser Leu Glu Glu Asn Ser 
        515                 520                 525             


Arg Leu Lys Ser Leu Leu Leu Ser Met Lys Lys Glu Val Lys Ser Ala 
    530                 535                 540                 


Asp Thr Ala Ala Thr Leu Asn Leu Gln Ile Ala Gly Leu Gln Thr Ser 
545                 550                 555                 560 


Val Lys Arg Leu Cys Gly Glu Ile Val Glu Leu Lys Gln His Leu Glu 
                565                 570                 575     


His Tyr Asp Lys Ile Gln Glu Leu Thr Gln Met Leu Gln Glu Ser His 
            580                 585                 590         


Ser Ser Leu Val Ser Thr Asn Glu His Leu Leu Gln Glu Leu Ser Gln 
        595                 600                 605             


Val Arg Ala Gln His Arg Ala Glu Val Glu Gln Met His Trp Ser Tyr 
    610                 615                 620                 


Gln Glu Leu Lys Lys Thr Met Ala Leu Phe Pro His Ser Ser Ala Ser 
625                 630                 635                 640 


His Gly Gly Cys Gln Ala Cys 
                645         


<210>  2044
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP76__Homo_sapiens__NP_001258918

<400>  2044

Met Ser Leu Pro Pro Glu Lys Ala Ser Glu Leu Lys Gln Leu Ile His 
1               5                   10                  15      


Gln Gln Leu Ser Lys Met Asp Val His Gly Arg Ile Arg Glu Ile Leu 
            20                  25                  30          


Ala Glu Thr Ile Arg Glu Glu Leu Ala Pro Asp Gln Gln His Leu Ser 
        35                  40                  45              


Thr Glu Asp Leu Ile Lys Ala Leu Arg Arg Arg Gly Ile Ile Asp Asp 
    50                  55                  60                  


Val Met Lys Glu Leu Asn Phe Val Thr Asp Ser Val Glu Gln Glu Leu 
65                  70                  75                  80  


Pro Ser Ser Pro Lys Gln Pro Ile Cys Phe Asp Arg Gln Ser Thr Leu 
                85                  90                  95      


Lys Lys Ser Asp Gly Thr Arg Met Ala Asp Ser Thr Thr Met Leu Ser 
            100                 105                 110         


Ile Ser Asp Pro Ile His Met Val Leu Ile Lys Thr Asp Ile Phe Gly 
        115                 120                 125             


Glu Thr Thr Leu Val Ala Ser Tyr Phe Leu Glu Trp Arg Ser Val Leu 
    130                 135                 140                 


Gly Ser Glu Asn Gly Val Thr Ser Leu Thr Val Glu Leu Met Gly Val 
145                 150                 155                 160 


Gly Thr Glu Ser Lys Val Ser Val Gly Ile Leu Asn Ile Lys Leu Glu 
                165                 170                 175     


Met Tyr Pro Pro Leu Asn Gln Thr Leu Ser Gln Glu Val Val Asn Thr 
            180                 185                 190         


Gln Leu Ala Leu Glu Arg Gln Lys Thr Ala Glu Lys Glu Arg Leu Phe 
        195                 200                 205             


Leu Val Tyr Ala Lys Gln Trp Trp Arg Glu Tyr Leu Gln Ile Arg Pro 
    210                 215                 220                 


Ser His Asn Ser Arg Leu Val Lys Ile Phe Ala Gln Asp Glu Asn Gly 
225                 230                 235                 240 


Ile Asn Arg Pro Val Cys Ser Tyr Val Lys Pro Leu Arg Ala Gly Arg 
                245                 250                 255     


Leu Leu Asp Thr Pro Arg Gln Ala Ala Arg Phe Val Asn Val Leu Gly 
            260                 265                 270         


Tyr Glu Arg Ala Pro Val Ile Gly Gly Gly Gly Lys Gln Glu Gln Trp 
        275                 280                 285             


Cys Thr Leu Leu Ala Phe Leu Cys Arg Asn Lys Gly Asp Cys Glu Asp 
    290                 295                 300                 


His Ala Asn Leu Leu Cys Ser Leu Leu Leu Gly Tyr Gly Leu Glu Ala 
305                 310                 315                 320 


Phe Val Cys Val Gly Thr Lys Ala Lys Gly Val Pro His Ala Trp Val 
                325                 330                 335     


Met Thr Cys Gly Thr Asp Gly Ala Ile Thr Phe Trp Glu Ser Leu Thr 
            340                 345                 350         


Gly His Arg Tyr Ile His Lys Pro Thr Asn Pro Asp Glu Pro Pro Val 
        355                 360                 365             


Ala Glu Gln Pro Lys Pro Leu Tyr Pro Tyr Arg Thr Ile Gly Cys Val 
    370                 375                 380                 


Phe Asn His Gln Met Phe Leu Gly Asn Cys Gln Pro Ser Asp Ala Val 
385                 390                 395                 400 


Glu Thr Cys Val Phe Asp Leu Asn Asp Glu Ser Lys Trp Lys Pro Met 
                405                 410                 415     


Ser Glu Glu Ala Ile Lys Ser Val Cys Ala Pro Gly Ala Thr Thr Ser 
            420                 425                 430         


Leu Pro Pro Phe Pro Pro Leu Cys Ala Ser Thr Ile Asp Ala Ser Val 
        435                 440                 445             


Thr Ser Asn Glu Ile Glu Met Gln Leu Arg Leu Leu Val Ser Glu His 
    450                 455                 460                 


Arg Lys Asp Leu Gly Leu Thr Thr Val Trp Glu Asp Gln Leu Ser Tyr 
465                 470                 475                 480 


Leu Leu Ser Pro Ala Leu Ala Ser Tyr Glu Phe Glu Arg Thr Thr Ser 
                485                 490                 495     


Ile Ser Ala Gly Asn Glu Glu Phe Gln Asp Ala Ile Arg Arg Ala Val 
            500                 505                 510         


Pro Asp Gly His Thr Phe Lys Gly Phe Pro Ile His Phe Val Tyr Arg 
        515                 520                 525             


Asn Ala Arg Arg Ala Phe Ala Thr Cys Leu Arg Ser Pro Phe Cys Glu 
    530                 535                 540                 


Glu Ile Ile Cys Cys Arg Gly Asp Gln Val Arg Leu Ala Val Arg Val 
545                 550                 555                 560 


Arg Val Phe Thr Tyr Pro Glu Ser Ala Cys Ala Val Trp Ile Met Phe 
                565                 570                 575     


Ala Cys Lys Tyr Arg Ser Val Leu 
            580                 


<210>  2045
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP83__Homo_sapiens__NP_057206

<400>  2045

Met Val Val Ser Thr Phe Thr Asp Met Asp Thr Phe Pro Asn Asn Phe 
1               5                   10                  15      


Pro Pro Gly Gly Asp Ser Gly Leu Thr Gly Ser Gln Ser Glu Phe Gln 
            20                  25                  30          


Lys Met Leu Ile Asp Glu Arg Leu Arg Cys Glu His His Lys Ala Asn 
        35                  40                  45              


Tyr Gln Thr Leu Lys Ala Glu His Thr Arg Leu Gln Asn Glu His Val 
    50                  55                  60                  


Lys Leu Gln Asn Glu Leu Lys His Leu Phe Asn Glu Lys Gln Thr Gln 
65                  70                  75                  80  


Gln Glu Lys Leu Gln Leu Leu Leu Glu Glu Leu Arg Gly Glu Leu Val 
                85                  90                  95      


Glu Lys Thr Lys Asp Leu Glu Glu Met Lys Leu Gln Ile Leu Thr Pro 
            100                 105                 110         


Gln Lys Leu Glu Leu Leu Arg Ala Gln Ile Gln Gln Glu Leu Glu Thr 
        115                 120                 125             


Pro Met Arg Glu Arg Phe Arg Asn Leu Asp Glu Glu Val Glu Lys Tyr 
    130                 135                 140                 


Arg Ala Val Tyr Asn Lys Leu Arg Tyr Glu His Thr Phe Leu Lys Ser 
145                 150                 155                 160 


Glu Phe Glu His Gln Lys Glu Glu Tyr Ala Arg Ile Leu Asp Glu Gly 
                165                 170                 175     


Lys Ile Lys Tyr Glu Ser Glu Ile Ala Arg Leu Glu Glu Asp Lys Glu 
            180                 185                 190         


Glu Leu Arg Asn Gln Leu Leu Asn Val Asp Leu Thr Lys Asp Ser Lys 
        195                 200                 205             


Arg Val Glu Gln Leu Ala Arg Glu Lys Val Tyr Leu Cys Gln Lys Leu 
    210                 215                 220                 


Lys Gly Leu Glu Ala Glu Val Ala Glu Leu Lys Ala Glu Lys Glu Asn 
225                 230                 235                 240 


Ser Glu Ala Gln Val Glu Asn Ala Gln Arg Ile Gln Val Arg Gln Leu 
                245                 250                 255     


Ala Glu Met Gln Ala Thr Val Arg Ser Leu Glu Ala Glu Lys Gln Ser 
            260                 265                 270         


Ala Asn Leu Arg Ala Glu Arg Leu Glu Lys Glu Leu Gln Ser Ser Ser 
        275                 280                 285             


Glu Gln Asn Thr Phe Leu Ile Asn Lys Leu His Lys Ala Glu Arg Glu 
    290                 295                 300                 


Ile Asn Thr Leu Ser Ser Lys Val Lys Glu Leu Lys His Ser Asn Lys 
305                 310                 315                 320 


Leu Glu Ile Thr Asp Ile Lys Leu Glu Thr Ala Arg Ala Lys Ser Glu 
                325                 330                 335     


Leu Glu Arg Glu Arg Asn Lys Ile Gln Ser Glu Leu Asp Gly Leu Gln 
            340                 345                 350         


Ser Asp Asn Glu Ile Leu Lys Ala Ala Val Glu His His Lys Val Leu 
        355                 360                 365             


Leu Val Glu Lys Asp Arg Glu Leu Ile Arg Lys Val Gln Ala Ala Lys 
    370                 375                 380                 


Glu Glu Gly Tyr Gln Lys Leu Val Val Leu Gln Asp Glu Lys Leu Glu 
385                 390                 395                 400 


Leu Glu Asn Arg Leu Ala Asp Leu Glu Lys Met Lys Val Glu His Asp 
                405                 410                 415     


Val Trp Arg Gln Ser Glu Lys Asp Gln Tyr Glu Glu Lys Leu Arg Ala 
            420                 425                 430         


Ser Gln Met Ala Glu Glu Ile Thr Arg Lys Glu Leu Gln Ser Val Arg 
        435                 440                 445             


Leu Lys Leu Gln Gln Gln Ile Val Thr Ile Glu Asn Ala Glu Lys Glu 
    450                 455                 460                 


Lys Asn Glu Asn Ser Asp Leu Lys Gln Gln Ile Ser Ser Leu Gln Ile 
465                 470                 475                 480 


Gln Val Thr Ser Leu Ala Gln Ser Glu Asn Asp Leu Leu Asn Ser Asn 
                485                 490                 495     


Gln Met Leu Lys Glu Met Val Glu Arg Leu Lys Gln Glu Cys Arg Asn 
            500                 505                 510         


Phe Arg Ser Gln Ala Glu Lys Ala Gln Leu Glu Ala Glu Lys Thr Leu 
        515                 520                 525             


Glu Glu Lys Gln Ile Gln Trp Leu Glu Glu Lys His Lys Leu His Glu 
    530                 535                 540                 


Arg Ile Thr Asp Arg Glu Glu Lys Tyr Asn Gln Ala Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Ala Ala Ile Ala Gln Lys Lys Arg Lys Ser Leu His Glu Asn 
                565                 570                 575     


Lys Leu Lys Arg Leu Gln Glu Lys Val Glu Val Leu Glu Ala Lys Lys 
            580                 585                 590         


Glu Glu Leu Glu Thr Glu Asn Gln Val Leu Asn Arg Gln Asn Val Pro 
        595                 600                 605             


Phe Glu Asp Tyr Thr Arg Leu Gln Lys Arg Leu Lys Asp Ile Gln Arg 
    610                 615                 620                 


Arg His Asn Glu Phe Arg Ser Leu Ile Leu Val Pro Asn Met Pro Pro 
625                 630                 635                 640 


Thr Ala Ser Ile Asn Pro Val Ser Phe Gln Ser Ser Ala Met Val Pro 
                645                 650                 655     


Ser Met Glu Leu Pro Phe Pro Pro His Met Gln Glu Glu Gln His Gln 
            660                 665                 670         


Arg Glu Leu Ser Leu Leu Arg Lys Arg Leu Glu Glu Leu Glu Thr Thr 
        675                 680                 685             


Gln Arg Lys Gln Leu Glu Glu Leu Gly Ser Ser Gly Glu 
    690                 695                 700     


<210>  2046
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP85L__Homo_sapiens__NP_001035940

<400>  2046

Met Trp Gly Arg Phe Leu Ala Pro Glu Ala Ser Gly Arg Asp Ser Pro 
1               5                   10                  15      


Gly Gly Ala Arg Ser Phe Pro Ala Gly Pro Asp Tyr Ser Ser Ala Trp 
            20                  25                  30          


Leu Pro Ala Asn Glu Ser Leu Trp Gln Ala Thr Thr Val Pro Ser Asn 
        35                  40                  45              


His Arg Asn Asn His Ile Arg Arg His Ser Ile Ala Ser Asp Ser Gly 
    50                  55                  60                  


Asp Thr Gly Ile Gly Thr Ser Cys Ser Asp Ser Val Glu Asp His Ser 
65                  70                  75                  80  


Thr Ser Ser Gly Thr Leu Ser Phe Lys Pro Ser Gln Ser Leu Ile Thr 
                85                  90                  95      


Leu Pro Thr Ala His Val Met Pro Ser Asn Ser Ser Ala Ser Ile Ser 
            100                 105                 110         


Lys Leu Arg Glu Ser Leu Thr Pro Asp Gly Ser Lys Trp Ser Thr Ser 
        115                 120                 125             


Leu Met Gln Thr Leu Gly Asn His Ser Arg Gly Glu Gln Asp Ser Ser 
    130                 135                 140                 


Leu Asp Met Lys Asp Phe Arg Pro Leu Arg Lys Trp Ser Ser Leu Ser 
145                 150                 155                 160 


Lys Leu Thr Ala Pro Asp Asn Cys Gly Gln Gly Gly Thr Val Cys Arg 
                165                 170                 175     


Glu Glu Ser Arg Asn Gly Leu Glu Lys Ile Gly Lys Ala Lys Ala Leu 
            180                 185                 190         


Thr Ser Gln Leu Arg Thr Ile Gly Pro Ser Cys Leu His Asp Ser Met 
        195                 200                 205             


Glu Met Leu Arg Leu Glu Asp Lys Glu Ile Asn Lys Lys Arg Ser Ser 
    210                 215                 220                 


Thr Leu Asp Cys Lys Tyr Lys Phe Glu Ser Cys Ser Lys Glu Asp Phe 
225                 230                 235                 240 


Arg Ala Ser Ser Ser Thr Leu Arg Arg Gln Pro Val Asp Met Thr Tyr 
                245                 250                 255     


Ser Ala Leu Pro Glu Ser Lys Pro Ile Met Thr Ser Ser Glu Ala Phe 
            260                 265                 270         


Glu Pro Pro Lys Tyr Leu Met Leu Gly Gln Gln Ala Val Gly Gly Val 
        275                 280                 285             


Pro Ile Gln Pro Ser Val Arg Thr Gln Met Trp Leu Thr Glu Gln Leu 
    290                 295                 300                 


Arg Thr Asn Pro Leu Glu Gly Arg Asn Thr Glu Asp Ser Tyr Ser Leu 
305                 310                 315                 320 


Ala Pro Trp Gln Gln Gln Gln Ile Glu Asp Phe Arg Gln Gly Ser Glu 
                325                 330                 335     


Thr Pro Met Gln Val Leu Thr Gly Ser Ser Arg Gln Ser Tyr Ser Pro 
            340                 345                 350         


Gly Tyr Gln Asp Phe Ser Lys Trp Glu Ser Met Leu Lys Ile Lys Glu 
        355                 360                 365             


Gly Leu Leu Arg Gln Lys Glu Ile Val Ile Asp Arg Gln Lys Gln Gln 
    370                 375                 380                 


Ile Thr His Leu His Glu Arg Ile Arg Asp Asn Glu Leu Arg Ala Gln 
385                 390                 395                 400 


His Ala Met Leu Gly His Tyr Val Asn Cys Glu Asp Ser Tyr Val Ala 
                405                 410                 415     


Ser Leu Gln Pro Gln Tyr Glu Asn Thr Ser Leu Gln Thr Pro Phe Ser 
            420                 425                 430         


Glu Glu Ser Val Ser His Ser Gln Gln Gly Glu Phe Glu Gln Lys Leu 
        435                 440                 445             


Ala Ser Thr Glu Lys Glu Val Leu Gln Leu Asn Glu Phe Leu Lys Gln 
    450                 455                 460                 


Arg Leu Ser Leu Phe Ser Glu Glu Lys Lys Lys Leu Glu Glu Lys Leu 
465                 470                 475                 480 


Lys Thr Arg Asp Arg Tyr Ile Ser Ser Leu Lys Lys Lys Cys Gln Lys 
                485                 490                 495     


Glu Ser Glu Gln Asn Lys Glu Lys Gln Arg Arg Ile Glu Thr Leu Glu 
            500                 505                 510         


Lys Tyr Leu Ala Asp Leu Pro Thr Leu Asp Asp Val Gln Ser Gln Ser 
        515                 520                 525             


Leu Gln Leu Gln Ile Leu Glu Glu Lys Asn Lys Asn Leu Gln Glu Ala 
    530                 535                 540                 


Leu Ile Asp Thr Glu Lys Lys Leu Glu Glu Ile Lys Lys Gln Cys Gln 
545                 550                 555                 560 


Asp Lys Glu Thr Gln Leu Ile Cys Gln Lys Lys Lys Glu Lys Glu Leu 
                565                 570                 575     


Val Thr Thr Val Gln Ser Leu Gln Gln Lys Val Glu Arg Cys Leu Glu 
            580                 585                 590         


Asp Gly Ile Arg Leu Pro Met Leu Asp Ala Lys Gln Leu Gln Asn Glu 
        595                 600                 605             


Asn Asp Asn Leu Arg Gln Gln Asn Glu Thr Ala Ser Lys Ile Ile Asp 
    610                 615                 620                 


Ser Gln Gln Asp Glu Ile Asp Arg Met Ile Leu Glu Ile Gln Ser Met 
625                 630                 635                 640 


Gln Gly Lys Leu Ser Lys Glu Lys Leu Thr Thr Gln Lys Met Met Glu 
                645                 650                 655     


Glu Leu Glu Lys Lys Glu Arg Asn Val Gln Arg Leu Thr Lys Ala Leu 
            660                 665                 670         


Leu Glu Asn Gln Arg Gln Thr Asp Glu Thr Cys Ser Leu Leu Asp Gln 
        675                 680                 685             


Gly Gln Glu Pro Asp Gln Ser Arg Gln Gln Thr Val Leu Ser Lys Arg 
    690                 695                 700                 


Pro Leu Phe Asp Leu Thr Val Ile Asp Gln Leu Phe Lys Glu Met Ser 
705                 710                 715                 720 


Cys Cys Leu Phe Asp Leu Lys Ala Leu Cys Ser Ile Leu Asn Gln Arg 
                725                 730                 735     


Ala Gln Gly Lys Glu Pro Asn Leu Ser Leu Leu Leu Gly Ile Arg Ser 
            740                 745                 750         


Met Asn Cys Ser Ala Glu Glu Thr Glu Asn Asp His Ser Thr Glu Thr 
        755                 760                 765             


Leu Thr Lys Lys Leu Ser Asp Val Cys Gln Leu Arg Arg Asp Ile Asp 
    770                 775                 780                 


Glu Leu Arg Thr Thr Ile Ser Asp Arg Tyr Ala Gln Asp Met Gly Asp 
785                 790                 795                 800 


Asn Cys Ile Thr Gln 
                805 


<210>  2047
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEP89__Homo_sapiens__NP_116205

<400>  2047

Met Leu Leu Gly Phe Arg Arg Gly Arg Arg Ser His Phe Lys His Ile 
1               5                   10                  15      


Ile His Gly Leu Leu Pro Ala Ala Ser Val Ala Pro Lys Ala Ala Val 
            20                  25                  30          


Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser Pro Glu Arg Pro 
        35                  40                  45              


Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr Leu Thr Gly Arg 
    50                  55                  60                  


Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg Ser Glu Ser Asp 
65                  70                  75                  80  


Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro Tyr Ala Thr Thr 
                85                  90                  95      


Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu Met Gly Arg Arg 
            100                 105                 110         


Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly Asp Glu Glu Asp 
        115                 120                 125             


Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu Gly Asp Val Ser 
    130                 135                 140                 


Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu Tyr Ala Val Pro 
145                 150                 155                 160 


His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn Ser Glu Asp Asp 
                165                 170                 175     


Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser Pro Pro Ala Pro 
            180                 185                 190         


Gln Arg Thr Gln Gln Lys Asp Gly Lys His Pro Val Leu Asn Leu Lys 
        195                 200                 205             


Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro Ser Pro Asp Ile 
    210                 215                 220                 


Thr Gly Arg Ala Arg Gln Arg Tyr Thr Glu Ile Thr Arg Glu Lys Phe 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Glu Asn Met Asp Leu Asn Asn Met Asn Gln Ser 
                245                 250                 255     


Leu Thr Leu Glu Leu Asn Thr Met Lys Gln Ala Met Lys Glu Leu Gln 
            260                 265                 270         


Leu Lys Leu Lys Gly Met Glu Lys Glu Lys Arg Lys Leu Lys Glu Ala 
        275                 280                 285             


Glu Lys Ala Ser Ser Gln Glu Val Ala Ala Pro Glu Leu Leu Tyr Leu 
    290                 295                 300                 


Arg Lys Gln Ala Gln Glu Leu Val Asp Glu Asn Asp Gly Leu Lys Met 
305                 310                 315                 320 


Thr Val His Arg Leu Asn Val Glu Leu Ser Arg Tyr Gln Thr Lys Phe 
                325                 330                 335     


Arg His Leu Ser Lys Glu Glu Ser Leu Asn Ile Glu Gly Leu Pro Ser 
            340                 345                 350         


Lys Gly Pro Ile Pro Pro Trp Leu Leu Asp Ile Lys Tyr Leu Ser Pro 
        355                 360                 365             


Leu Leu Leu Ala Tyr Glu Asp Met Met Lys Glu Lys Asp Glu Leu Asn 
    370                 375                 380                 


Ala Thr Leu Lys Glu Glu Met Arg Met Phe Arg Met Arg Val Gln Glu 
385                 390                 395                 400 


Val Val Lys Glu Asn Glu Glu Leu His Gln Glu Leu Asn Lys Ser Ser 
                405                 410                 415     


Ala Val Thr Ser Glu Glu Trp Arg Gln Leu Gln Thr Gln Ala Lys Leu 
            420                 425                 430         


Val Leu Glu Glu Asn Lys Leu Leu Leu Glu Gln Leu Glu Ile Gln Gln 
        435                 440                 445             


Arg Lys Ala Lys Asp Ser His Gln Glu Arg Leu Gln Glu Val Ser Lys 
    450                 455                 460                 


Leu Thr Lys Gln Leu Met Leu Leu Glu Ala Lys Thr His Gly Gln Glu 
465                 470                 475                 480 


Lys Glu Leu Ala Glu Asn Arg Glu Gln Leu Glu Ile Leu Arg Ala Lys 
                485                 490                 495     


Cys Gln Glu Leu Lys Thr His Ser Asp Gly Lys Ile Ala Val Glu Val 
            500                 505                 510         


His Lys Ser Ile Val Asn Glu Leu Lys Ser Gln Leu Gln Lys Glu Glu 
        515                 520                 525             


Glu Lys Glu Arg Ala Glu Met Glu Glu Leu Met Glu Lys Leu Thr Val 
    530                 535                 540                 


Leu Gln Ala Gln Lys Lys Ser Leu Leu Leu Glu Lys Asn Ser Leu Thr 
545                 550                 555                 560 


Glu Gln Asn Lys Ala Leu Glu Ala Glu Leu Glu Arg Ala Gln Lys Ile 
                565                 570                 575     


Asn Arg Lys Ser Gln Lys Lys Ile Glu Val Leu Lys Lys Gln Val Glu 
            580                 585                 590         


Lys Ala Met Gly Asn Glu Met Ser Ala His Gln Tyr Leu Ala Asn Leu 
        595                 600                 605             


Val Gly Leu Ala Glu Asn Ile Thr Gln Glu Arg Asp Ser Leu Met Cys 
    610                 615                 620                 


Leu Ala Lys Cys Leu Glu Ser Glu Lys Asp Gly Val Leu Asn Lys Val 
625                 630                 635                 640 


Ile Lys Ser Asn Ile Arg Leu Gly Lys Leu Glu Glu Lys Val Lys Gly 
                645                 650                 655     


Tyr Lys Lys Gln Ala Ala Leu Lys Leu Gly Asp Ile Ser His Arg Leu 
            660                 665                 670         


Leu Glu Gln Gln Glu Asp Phe Ala Gly Lys Thr Ala Gln Tyr Arg Gln 
        675                 680                 685             


Glu Met Arg His Leu His Gln Val Leu Lys Asp Lys Gln Glu Val Leu 
    690                 695                 700                 


Asp Gln Ala Leu Gln Gln Asn Arg Glu Met Glu Gly Glu Leu Glu Val 
705                 710                 715                 720 


Ile Trp Glu Ser Thr Phe Arg Glu Asn Arg Arg Ile Arg Glu Leu Leu 
                725                 730                 735     


Gln Asp Thr Leu Thr Arg Thr Gly Val Gln Asp Asn Pro Arg Ala Leu 
            740                 745                 750         


Val Ala Pro Ser Leu Asn Gly Val Ser Gln Ala Asp Leu Leu Asp Gly 
        755                 760                 765             


Cys Asp Val Cys Ser Tyr Asp Leu Lys Ser His Ala Pro Thr Cys 
    770                 775                 780             


<210>  2048
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CER1__Homo_sapiens__NP_005445

<400>  2048

Met His Leu Leu Leu Phe Gln Leu Leu Val Leu Leu Pro Leu Gly Lys 
1               5                   10                  15      


Thr Thr Arg His Gln Asp Gly Arg Gln Asn Gln Ser Ser Leu Ser Pro 
            20                  25                  30          


Val Leu Leu Pro Arg Asn Gln Arg Glu Leu Pro Thr Gly Asn His Glu 
        35                  40                  45              


Glu Ala Glu Glu Lys Pro Asp Leu Phe Val Ala Val Pro His Leu Val 
    50                  55                  60                  


Ala Thr Ser Pro Ala Gly Glu Gly Gln Arg Gln Arg Glu Lys Met Leu 
65                  70                  75                  80  


Ser Arg Phe Gly Arg Phe Trp Lys Lys Pro Glu Arg Glu Met His Pro 
                85                  90                  95      


Ser Arg Asp Ser Asp Ser Glu Pro Phe Pro Pro Gly Thr Gln Ser Leu 
            100                 105                 110         


Ile Gln Pro Ile Asp Gly Met Lys Met Glu Lys Ser Pro Leu Arg Glu 
        115                 120                 125             


Glu Ala Lys Lys Phe Trp His His Phe Met Phe Arg Lys Thr Pro Ala 
    130                 135                 140                 


Ser Gln Gly Val Ile Leu Pro Ile Lys Ser His Glu Val His Trp Glu 
145                 150                 155                 160 


Thr Cys Arg Thr Val Pro Phe Ser Gln Thr Ile Thr His Glu Gly Cys 
                165                 170                 175     


Glu Lys Val Val Val Gln Asn Asn Leu Cys Phe Gly Lys Cys Gly Ser 
            180                 185                 190         


Val His Phe Pro Gly Ala Ala Gln His Ser His Thr Ser Cys Ser His 
        195                 200                 205             


Cys Leu Pro Ala Lys Phe Thr Thr Met His Leu Pro Leu Asn Cys Thr 
    210                 215                 220                 


Glu Leu Ser Ser Val Ile Lys Val Val Met Leu Val Glu Glu Cys Gln 
225                 230                 235                 240 


Cys Lys Val Lys Thr Glu His Glu Asp Gly His Ile Leu His Ala Gly 
                245                 250                 255     


Ser Gln Asp Ser Phe Ile Pro Gly Val Ser Ala 
            260                 265         


<210>  2049
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CERK__Homo_sapiens__NP_073603

<400>  2049

Met Gly Ala Thr Gly Ala Ala Glu Pro Leu Gln Ser Val Leu Trp Val 
1               5                   10                  15      


Lys Gln Gln Arg Cys Ala Val Ser Leu Glu Pro Ala Arg Ala Leu Leu 
            20                  25                  30          


Arg Trp Trp Arg Ser Pro Gly Pro Gly Ala Gly Ala Pro Gly Ala Asp 
        35                  40                  45              


Ala Cys Ser Val Pro Val Ser Glu Ile Ile Ala Val Glu Glu Thr Asp 
    50                  55                  60                  


Val His Gly Lys His Gln Gly Ser Gly Lys Trp Gln Lys Met Glu Lys 
65                  70                  75                  80  


Pro Tyr Ala Phe Thr Val His Cys Val Lys Arg Ala Arg Arg His Arg 
                85                  90                  95      


Trp Lys Trp Ala Gln Val Thr Phe Trp Cys Pro Glu Glu Gln Leu Cys 
            100                 105                 110         


His Leu Trp Leu Gln Thr Leu Arg Glu Met Leu Glu Lys Leu Thr Ser 
        115                 120                 125             


Arg Pro Lys His Leu Leu Val Phe Ile Asn Pro Phe Gly Gly Lys Gly 
    130                 135                 140                 


Gln Gly Lys Arg Ile Tyr Glu Arg Lys Val Ala Pro Leu Phe Thr Leu 
145                 150                 155                 160 


Ala Ser Ile Thr Thr Asp Ile Ile Val Thr Glu His Ala Asn Gln Ala 
                165                 170                 175     


Lys Glu Thr Leu Tyr Glu Ile Asn Ile Asp Lys Tyr Asp Gly Ile Val 
            180                 185                 190         


Cys Val Gly Gly Asp Gly Met Phe Ser Glu Val Leu His Gly Leu Ile 
        195                 200                 205             


Gly Arg Thr Gln Arg Ser Ala Gly Val Asp Gln Asn His Pro Arg Ala 
    210                 215                 220                 


Val Leu Val Pro Ser Ser Leu Arg Ile Gly Ile Ile Pro Ala Gly Ser 
225                 230                 235                 240 


Thr Asp Cys Val Cys Tyr Ser Thr Val Gly Thr Ser Asp Ala Glu Thr 
                245                 250                 255     


Ser Ala Leu His Ile Val Val Gly Asp Ser Leu Ala Met Asp Val Ser 
            260                 265                 270         


Ser Val His His Asn Ser Thr Leu Leu Arg Tyr Ser Val Ser Leu Leu 
        275                 280                 285             


Gly Tyr Gly Phe Tyr Gly Asp Ile Ile Lys Asp Ser Glu Lys Lys Arg 
    290                 295                 300                 


Trp Leu Gly Leu Ala Arg Tyr Asp Phe Ser Gly Leu Lys Thr Phe Leu 
305                 310                 315                 320 


Ser His His Cys Tyr Glu Gly Thr Val Ser Phe Leu Pro Ala Gln His 
                325                 330                 335     


Thr Val Gly Ser Pro Arg Asp Arg Lys Pro Cys Arg Ala Gly Cys Phe 
            340                 345                 350         


Val Cys Arg Gln Ser Lys Gln Gln Leu Glu Glu Glu Gln Lys Lys Ala 
        355                 360                 365             


Leu Tyr Gly Leu Glu Ala Ala Glu Asp Val Glu Glu Trp Gln Val Val 
    370                 375                 380                 


Cys Gly Lys Phe Leu Ala Ile Asn Ala Thr Asn Met Ser Cys Ala Cys 
385                 390                 395                 400 


Arg Arg Ser Pro Arg Gly Leu Ser Pro Ala Ala His Leu Gly Asp Gly 
                405                 410                 415     


Ser Ser Asp Leu Ile Leu Ile Arg Lys Cys Ser Arg Phe Asn Phe Leu 
            420                 425                 430         


Arg Phe Leu Ile Arg His Thr Asn Gln Gln Asp Gln Phe Asp Phe Thr 
        435                 440                 445             


Phe Val Glu Val Tyr Arg Val Lys Lys Phe Gln Phe Thr Ser Lys His 
    450                 455                 460                 


Met Glu Asp Glu Asp Ser Asp Leu Lys Glu Gly Gly Lys Lys Arg Phe 
465                 470                 475                 480 


Gly His Ile Cys Ser Ser His Pro Ser Cys Cys Cys Thr Val Ser Asn 
                485                 490                 495     


Ser Ser Trp Asn Cys Asp Gly Glu Val Leu His Ser Pro Ala Ile Glu 
            500                 505                 510         


Val Arg Val His Cys Gln Leu Val Arg Leu Phe Ala Arg Gly Ile Glu 
        515                 520                 525             


Glu Asn Pro Lys Pro Asp Ser His Ser 
    530                 535         


<210>  2050
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CERKL__Homo_sapiens__NP_001025482

<400>  2050

Met Pro Trp Arg Arg Arg Arg Asn Arg Val Ser Ala Leu Glu Gly Gly 
1               5                   10                  15      


Arg Glu Glu Glu Ala Pro Pro Glu Ala Ala Ala Val Pro Pro Ala Leu 
            20                  25                  30          


Leu Thr Ser Pro Gln Gln Thr Glu Ala Ala Ala Glu Arg Ile Leu Leu 
        35                  40                  45              


Arg Gly Ile Phe Glu Ile Gly Arg Asp Ser Cys Asp Val Val Leu Ser 
    50                  55                  60                  


Glu Arg Ala Leu Arg Trp Arg Pro Ile Gln Pro Glu Arg Pro Ala Gly 
65                  70                  75                  80  


Asp Ser Lys Tyr Asp Leu Leu Cys Lys Glu Glu Phe Ile Glu Leu Lys 
                85                  90                  95      


Asp Ile Phe Ser Val Lys Leu Lys Arg Arg Cys Ser Val Lys Gln Gln 
            100                 105                 110         


Arg Ser Gly Thr Leu Leu Gly Ile Thr Leu Phe Ile Cys Leu Lys Lys 
        115                 120                 125             


Glu Gln Asn Lys Leu Lys Asn Ser Thr Leu Asp Leu Ile Asn Leu Ser 
    130                 135                 140                 


Glu Asp His Cys Asp Ile Trp Phe Arg Gln Phe Lys Lys Ile Leu Ala 
145                 150                 155                 160 


Gly Phe Pro Asn Arg Pro Lys Ser Leu Lys Ile Leu Leu Asn Pro Gln 
                165                 170                 175     


Ser His Lys Lys Glu Ala Thr Gln Val Tyr Tyr Glu Lys Val Glu Pro 
            180                 185                 190         


Leu Leu Lys Leu Ala Gly Ile Lys Thr Asp Val Thr Ile Met Glu Tyr 
        195                 200                 205             


Glu Gly His Ala Leu Ser Leu Leu Lys Glu Cys Glu Leu Gln Gly Phe 
    210                 215                 220                 


Asp Gly Gly His Arg Lys Pro Leu Phe Ala Ile His Trp Ser Val Gln 
225                 230                 235                 240 


Arg Leu Phe Thr Gly Met Gln Thr Leu Glu Pro Ser Val Val Cys Val 
                245                 250                 255     


Gly Gly Asp Gly Ser Ala Ser Glu Val Ala His Ala Leu Leu Leu Arg 
            260                 265                 270         


Ala Gln Lys Asn Ala Gly Met Glu Thr Asp Arg Ile Leu Thr Pro Val 
        275                 280                 285             


Arg Ala Gln Leu Pro Leu Gly Leu Ile Pro Ala Gly Ser Thr Asn Val 
    290                 295                 300                 


Leu Ala His Ser Leu His Gly Val Pro His Val Ile Thr Ala Thr Leu 
305                 310                 315                 320 


His Ile Ile Met Gly His Val Gln Leu Val Asp Val Cys Thr Phe Ser 
                325                 330                 335     


Thr Ala Gly Lys Leu Leu Arg Phe Gly Phe Ser Ala Met Phe Gly Phe 
            340                 345                 350         


Gly Gly Arg Thr Leu Ala Leu Ala Glu Lys Tyr Arg Trp Met Ser Pro 
        355                 360                 365             


Asn Gln Arg Arg Asp Phe Ala Val Val Lys Ala Leu Ala Lys Leu Lys 
    370                 375                 380                 


Ala Glu Asp Cys Glu Ile Ser Phe Leu Pro Phe Asn Ser Ser Asp Asp 
385                 390                 395                 400 


Val Gln Glu Arg Arg Ala Gln Gly Ser Pro Lys Ser Asp Cys Asn Asp 
                405                 410                 415     


Gln Trp Gln Met Ile Gln Gly Gln Phe Leu Asn Val Ser Ile Met Ala 
            420                 425                 430         


Ile Pro Cys Leu Cys Ser Val Ala Pro Arg Gly Leu Ala Pro Asn Thr 
        435                 440                 445             


Arg Leu Asn Asn Gly Ser Met Ala Leu Ile Ile Ala Arg Asn Thr Ser 
    450                 455                 460                 


Arg Pro Glu Phe Ile Lys His Leu Lys Arg Tyr Ala Ser Val Lys Asn 
465                 470                 475                 480 


Gln Phe Asn Phe Pro Phe Val Glu Thr Tyr Thr Val Glu Glu Val Lys 
                485                 490                 495     


Val His Pro Arg Asn Asn Thr Gly Gly Tyr Asn Pro Glu Glu Glu Glu 
            500                 505                 510         


Asp Glu Thr Ala Ser Glu Asn Cys Phe Pro Trp Asn Val Asp Gly Asp 
        515                 520                 525             


Leu Met Glu Val Ala Ser Glu Val His Ile Arg Leu His Pro Arg Leu 
    530                 535                 540                 


Ile Ser Leu Tyr Gly Gly Ser Met Glu Glu Met Ile Pro Lys 
545                 550                 555             


<210>  2051
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CERS1__Homo_sapiens__NP_001277194

<400>  2051

Met Pro Glu Ser Ala Trp Lys Phe Leu Phe Tyr Leu Gly Ser Trp Ser 
1               5                   10                  15      


Tyr Ser Ala Tyr Leu Leu Phe Gly Thr Asp Tyr Pro Phe Phe His Asp 
            20                  25                  30          


Pro Pro Ser Val Phe Tyr Asp Trp Thr Pro Gly Met Ala Val Pro Arg 
        35                  40                  45              


Asp Ile Ala Ala Ala Tyr Leu Leu Gln Gly Ser Phe Tyr Gly His Ser 
    50                  55                  60                  


Ile Tyr Ala Thr Leu Tyr Met Asp Thr Trp Arg Lys Asp Ser Val Val 
65                  70                  75                  80  


Met Leu Leu His His Val Val Thr Leu Ile Leu Ile Val Ser Ser Tyr 
                85                  90                  95      


Ala Phe Arg Tyr His Asn Val Gly Ile Leu Val Leu Phe Leu His Asp 
            100                 105                 110         


Ile Ser Asp Val Gln Leu Glu Phe Thr Lys Leu Asn Ile Tyr Phe Lys 
        115                 120                 125             


Ser Arg Gly Gly Ser Tyr His Arg Leu His Ala Leu Ala Ala Asp Leu 
    130                 135                 140                 


Gly Cys Leu Ser Phe Gly Phe Ser Trp Phe Trp Phe Arg Leu Tyr Trp 
145                 150                 155                 160 


Phe Pro Leu Lys Val Leu Tyr Ala Thr Ser His Cys Ser Leu Arg Thr 
                165                 170                 175     


Val Pro Asp Ile Pro Phe Tyr Phe Phe Phe Asn Ala Leu Leu Leu Leu 
            180                 185                 190         


Leu Thr Leu Met Asn Leu Tyr Trp Phe Leu Tyr Ile Val Ala Phe Ala 
        195                 200                 205             


Ala Lys Val Leu Thr Gly Gln Val His Glu Leu Lys Asp Leu Arg Glu 
    210                 215                 220                 


Tyr Asp Thr Ala Glu Ala Gln Ser Leu Lys Pro Ser Lys Ala Glu 
225                 230                 235                 


<210>  2052
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CERS2__Homo_sapiens__XP_011507753

<400>  2052

Met Val Pro Leu Ala Leu His Phe Pro Gly Glu Val Gly Leu Gln Glu 
1               5                   10                  15      


Thr Ala Val Arg Met Leu Gln Thr Leu Tyr Asp Tyr Phe Trp Trp Glu 
            20                  25                  30          


Arg Leu Trp Leu Pro Val Asn Leu Thr Trp Ala Asp Leu Glu Asp Arg 
        35                  40                  45              


Asp Gly Arg Val Tyr Ala Lys Ala Ser Asp Leu Tyr Ile Thr Leu Pro 
    50                  55                  60                  


Leu Ala Leu Leu Phe Leu Ile Val Arg Tyr Phe Phe Glu Leu Tyr Val 
65                  70                  75                  80  


Ala Thr Pro Leu Ala Ala Leu Leu Asn Ile Lys Glu Lys Thr Arg Leu 
                85                  90                  95      


Arg Ala Pro Pro Asn Ala Thr Leu Glu His Phe Tyr Leu Thr Ser Gly 
            100                 105                 110         


Lys Gln Pro Lys Gln Val Glu Val Glu Leu Leu Ser Arg Gln Ser Gly 
        115                 120                 125             


Leu Ser Gly Arg Gln Val Glu Arg Trp Phe Arg Arg Arg Arg Asn Gln 
    130                 135                 140                 


Asp Arg Pro Ser Leu Leu Lys Lys Phe Arg Glu Ala Ser Trp Arg Phe 
145                 150                 155                 160 


Thr Phe Tyr Leu Ile Ala Phe Ile Ala Gly Met Ala Val Ile Val Asp 
                165                 170                 175     


Lys Pro Trp Phe Tyr Asp Met Lys Lys Val Trp Glu Gly Tyr Pro Ile 
            180                 185                 190         


Gln Ser Thr Ile Pro Ser Gln Tyr Trp Tyr Tyr Met Ile Glu Leu Ser 
        195                 200                 205             


Phe Tyr Trp Ser Leu Leu Phe Ser Ile Ala Ser Asp Val Lys Arg Lys 
    210                 215                 220                 


Asp Phe Lys Glu Gln Ile Ile His His Val Ala Thr Ile Ile Leu Ile 
225                 230                 235                 240 


Ser Phe Ser Trp Phe Ala Asn Tyr Ile Arg Ala Gly Thr Leu Ile Met 
                245                 250                 255     


Ala Leu His Asp Ser Ser Asp Tyr Leu Leu Glu Ser Ala Lys Met Phe 
            260                 265                 270         


Asn Tyr Ala Gly Trp Lys Asn Thr Cys Asn Asn Ile Phe Ile Val Phe 
        275                 280                 285             


Ala Ile Val Phe Ile Ile Thr Arg Leu Val Ile Leu Pro Phe Trp Ile 
    290                 295                 300                 


Leu His Cys Thr Leu Val Tyr Pro Leu Glu Leu Tyr Pro Ala Phe Phe 
305                 310                 315                 320 


Gly Tyr Tyr Phe Phe Asn Ser Met Met Gly Val Leu Gln Leu Leu His 
                325                 330                 335     


Ile Phe Trp Ala Tyr Leu Ile Leu Arg Met Ala His Lys Phe Ile Thr 
            340                 345                 350         


Gly Lys Leu Val Glu Asp Glu Arg Ser Asp Arg Glu Glu Thr Glu Ser 
        355                 360                 365             


Ser Glu Gly Glu Glu Ala Ala Ala Gly Gly Gly Ala Lys Ser Arg Pro 
    370                 375                 380                 


Leu Ala Asn Gly His Pro Ile Leu Asn Asn Asn His Arg Lys Asn Asp 
385                 390                 395                 400 


<210>  2053
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CERS3__Homo_sapiens__NP_001277270

<400>  2053

Met Leu His Thr Thr Ala Arg Arg Ala Ala Arg Met Phe Trp Thr Phe 
1               5                   10                  15      


Lys Glu Trp Phe Trp Leu Glu Arg Phe Trp Leu Pro Pro Thr Ile Lys 
            20                  25                  30          


Trp Ser Asp Leu Glu Asp His Asp Gly Leu Val Phe Val Lys Pro Ser 
        35                  40                  45              


His Leu Tyr Val Thr Ile Pro Tyr Ala Phe Leu Leu Leu Ile Ile Arg 
    50                  55                  60                  


Arg Val Phe Glu Lys Phe Val Ala Ser Pro Leu Ala Lys Ser Phe Gly 
65                  70                  75                  80  


Ile Lys Glu Thr Val Arg Lys Val Thr Pro Asn Thr Val Leu Glu Asn 
                85                  90                  95      


Phe Phe Lys His Ser Thr Arg Gln Pro Leu Gln Thr Asp Ile Tyr Gly 
            100                 105                 110         


Leu Ala Lys Lys Cys Asn Leu Thr Glu Arg Gln Val Glu Arg Trp Phe 
        115                 120                 125             


Arg Ser Arg Arg Asn Gln Glu Arg Pro Ser Arg Leu Lys Lys Phe Gln 
    130                 135                 140                 


Glu Ala Cys Trp Arg Phe Ala Phe Tyr Leu Met Ile Thr Val Ala Gly 
145                 150                 155                 160 


Ile Ala Phe Leu Tyr Asp Lys Pro Trp Leu Tyr Asp Leu Trp Glu Val 
                165                 170                 175     


Trp Asn Gly Tyr Pro Lys Gln Pro Leu Leu Pro Ser Gln Tyr Trp Tyr 
            180                 185                 190         


Tyr Ile Leu Glu Met Ser Phe Tyr Trp Ser Leu Leu Phe Arg Leu Gly 
        195                 200                 205             


Phe Asp Val Lys Arg Lys Asp Phe Leu Ala His Ile Ile His His Leu 
    210                 215                 220                 


Ala Ala Ile Ser Leu Met Ser Phe Ser Trp Cys Ala Asn Tyr Ile Arg 
225                 230                 235                 240 


Ser Gly Thr Leu Val Met Ile Val His Asp Val Ala Asp Ile Trp Leu 
                245                 250                 255     


Glu Ser Ala Lys Met Phe Ser Tyr Ala Gly Trp Thr Gln Thr Cys Asn 
            260                 265                 270         


Thr Leu Phe Phe Ile Phe Ser Thr Ile Phe Phe Ile Ser Arg Leu Ile 
        275                 280                 285             


Val Phe Pro Phe Trp Ile Leu Tyr Cys Thr Leu Ile Leu Pro Met Tyr 
    290                 295                 300                 


His Leu Glu Pro Phe Phe Ser Tyr Ile Phe Leu Asn Leu Gln Leu Met 
305                 310                 315                 320 


Ile Leu Gln Val Leu His Leu Tyr Trp Gly Tyr Tyr Ile Leu Lys Met 
                325                 330                 335     


Leu Asn Arg Cys Ile Phe Met Lys Ser Ile Gln Asp Val Arg Ser Asp 
            340                 345                 350         


Asp Glu Asp Tyr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Thr 
        355                 360                 365             


Lys Gly Lys Glu Met Asp Cys Leu Lys Asn Gly Leu Arg Ala Glu Arg 
    370                 375                 380                 


His Leu Ile Pro Asn Gly Gln His Gly His 
385                 390                 


<210>  2054
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CERS4__Homo_sapiens__NP_078828

<400>  2054

Met Leu Ser Ser Phe Asn Glu Trp Phe Trp Gln Asp Arg Phe Trp Leu 
1               5                   10                  15      


Pro Pro Asn Val Thr Trp Thr Glu Leu Glu Asp Arg Asp Gly Arg Val 
            20                  25                  30          


Tyr Pro His Pro Gln Asp Leu Leu Ala Ala Leu Pro Leu Ala Leu Val 
        35                  40                  45              


Leu Leu Ala Met Arg Leu Ala Phe Glu Arg Phe Ile Gly Leu Pro Leu 
    50                  55                  60                  


Ser Arg Trp Leu Gly Val Arg Asp Gln Thr Arg Arg Gln Val Lys Pro 
65                  70                  75                  80  


Asn Ala Thr Leu Glu Lys His Phe Leu Thr Glu Gly His Arg Pro Lys 
                85                  90                  95      


Glu Pro Gln Leu Ser Leu Leu Ala Ala Gln Cys Gly Leu Thr Leu Gln 
            100                 105                 110         


Gln Thr Gln Arg Trp Phe Arg Arg Arg Arg Asn Gln Asp Arg Pro Gln 
        115                 120                 125             


Leu Thr Lys Lys Phe Cys Glu Ala Ser Trp Arg Phe Leu Phe Tyr Leu 
    130                 135                 140                 


Ser Ser Phe Val Gly Gly Leu Ser Val Leu Tyr His Glu Ser Trp Leu 
145                 150                 155                 160 


Trp Ala Pro Val Met Cys Trp Asp Arg Tyr Pro Asn Gln Thr Leu Lys 
                165                 170                 175     


Pro Ser Leu Tyr Trp Trp Tyr Leu Leu Glu Leu Gly Phe Tyr Leu Ser 
            180                 185                 190         


Leu Leu Ile Arg Leu Pro Phe Asp Val Lys Arg Lys Asp Phe Lys Glu 
        195                 200                 205             


Gln Val Ile His His Phe Val Ala Val Ile Leu Met Thr Phe Ser Tyr 
    210                 215                 220                 


Ser Ala Asn Leu Leu Arg Ile Gly Ser Leu Val Leu Leu Leu His Asp 
225                 230                 235                 240 


Ser Ser Asp Tyr Leu Leu Glu Ala Cys Lys Met Val Asn Tyr Met Gln 
                245                 250                 255     


Tyr Gln Gln Val Cys Asp Ala Leu Phe Leu Ile Phe Ser Phe Val Phe 
            260                 265                 270         


Phe Tyr Thr Arg Leu Val Leu Phe Pro Thr Gln Ile Leu Tyr Thr Thr 
        275                 280                 285             


Tyr Tyr Glu Ser Ile Ser Asn Arg Gly Pro Phe Phe Gly Tyr Tyr Phe 
    290                 295                 300                 


Phe Asn Gly Leu Leu Met Leu Leu Gln Leu Leu His Val Phe Trp Ser 
305                 310                 315                 320 


Cys Leu Ile Leu Arg Met Leu Tyr Ser Phe Met Lys Lys Gly Gln Met 
                325                 330                 335     


Glu Lys Asp Ile Arg Ser Asp Val Glu Glu Ser Asp Ser Ser Glu Glu 
            340                 345                 350         


Ala Ala Ala Ala Gln Glu Pro Leu Gln Leu Lys Asn Gly Ala Ala Gly 
        355                 360                 365             


Gly Pro Arg Pro Ala Pro Thr Asp Gly Pro Arg Ser Arg Val Ala Gly 
    370                 375                 380                 


Arg Leu Thr Asn Arg His Thr Thr Ala Thr 
385                 390                 


<210>  2055
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CERS6__Homo_sapiens__NP_001243055

<400>  2055

Met Ala Gly Ile Leu Ala Trp Phe Trp Asn Glu Arg Phe Trp Leu Pro 
1               5                   10                  15      


His Asn Val Thr Trp Ala Asp Leu Lys Asn Thr Glu Glu Ala Thr Phe 
            20                  25                  30          


Pro Gln Ala Glu Asp Leu Tyr Leu Ala Phe Pro Leu Ala Phe Cys Ile 
        35                  40                  45              


Phe Met Val Arg Leu Ile Phe Glu Arg Phe Val Ala Lys Pro Cys Ala 
    50                  55                  60                  


Ile Ala Leu Asn Ile Gln Ala Asn Gly Pro Gln Ile Ala Pro Pro Asn 
65                  70                  75                  80  


Ala Ile Leu Glu Lys Val Phe Thr Ala Ile Thr Lys His Pro Asp Glu 
                85                  90                  95      


Lys Arg Leu Glu Gly Leu Ser Lys Gln Leu Asp Trp Asp Val Arg Ser 
            100                 105                 110         


Ile Gln Arg Trp Phe Arg Gln Arg Arg Asn Gln Glu Lys Pro Ser Thr 
        115                 120                 125             


Leu Thr Arg Phe Cys Glu Ser Met Trp Arg Phe Ser Phe Tyr Leu Tyr 
    130                 135                 140                 


Val Phe Thr Tyr Gly Val Arg Phe Leu Lys Lys Thr Pro Trp Leu Trp 
145                 150                 155                 160 


Asn Thr Arg His Cys Trp Tyr Asn Tyr Pro Tyr Gln Pro Leu Thr Thr 
                165                 170                 175     


Asp Leu His Tyr Tyr Tyr Ile Leu Glu Leu Ser Phe Tyr Trp Ser Leu 
            180                 185                 190         


Met Phe Ser Gln Phe Thr Asp Ile Lys Arg Lys Asp Phe Gly Ile Met 
        195                 200                 205             


Phe Leu His His Leu Val Ser Ile Phe Leu Ile Thr Phe Ser Tyr Val 
    210                 215                 220                 


Asn Asn Met Ala Arg Val Gly Thr Leu Val Leu Cys Leu His Asp Ser 
225                 230                 235                 240 


Ala Asp Ala Leu Leu Glu Ala Ala Lys Met Ala Asn Tyr Ala Lys Phe 
                245                 250                 255     


Gln Lys Met Cys Asp Leu Leu Phe Val Met Phe Ala Val Val Phe Ile 
            260                 265                 270         


Thr Thr Arg Leu Gly Ile Phe Pro Leu Trp Val Leu Asn Thr Thr Leu 
        275                 280                 285             


Phe Glu Ser Trp Glu Ile Val Gly Pro Tyr Pro Ser Trp Trp Val Phe 
    290                 295                 300                 


Asn Leu Leu Leu Leu Leu Val Gln Gly Leu Asn Cys Phe Trp Ser Tyr 
305                 310                 315                 320 


Leu Ile Val Lys Ile Ala Cys Lys Ala Val Ser Arg Gly Lys Ala Gly 
                325                 330                 335     


Lys Trp Asn Pro Leu His Val Ser Lys Asp Asp Arg Ser Asp Ile Glu 
            340                 345                 350         


Ser Ser Ser Asp Glu Glu Asp Ser Glu Pro Pro Gly Lys Asn Pro His 
        355                 360                 365             


Thr Ala Thr Thr Thr Asn Gly Thr Ser Gly Thr Asn Gly Tyr Leu Leu 
    370                 375                 380                 


Thr Gly Ser Cys Ser Met Asp Asp 
385                 390         


<210>  2056
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CES1__Homo_sapiens__NP_001020365

<400>  2056

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala 
            260                 265                 270         


Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg Gln 
        275                 280                 285             


Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe Leu 
    290                 295                 300                 


Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly 
305                 310                 315                 320 


Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln 
                325                 330                 335     


Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys 
            340                 345                 350         


Gln Glu Phe Gly Trp Leu Ile Pro Met Gln Leu Met Ser Tyr Pro Leu 
        355                 360                 365             


Ser Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp Lys 
    370                 375                 380                 


Ser Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr 
385                 390                 395                 400 


Glu Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp Leu 
                405                 410                 415     


Phe Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val Ile 
            420                 425                 430         


Val Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu 
        435                 440                 445             


Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr Val 
    450                 455                 460                 


Ile Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro Phe 
465                 470                 475                 480 


Leu Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val 
                485                 490                 495     


Met Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu 
            500                 505                 510         


Gly Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln 
        515                 520                 525             


Ile Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val 
    530                 535                 540                 


Ala Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro 
545                 550                 555                 560 


Gln Thr Glu His Ile Glu Leu 
                565         


<210>  2057
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CES2__Homo_sapiens__NP_003860

<400>  2057

Met Thr Ala Gln Ser Arg Ser Pro Thr Thr Pro Thr Phe Pro Gly Pro 
1               5                   10                  15      


Ser Gln Arg Thr Pro Leu Thr Pro Cys Pro Val Gln Thr Pro Arg Leu 
            20                  25                  30          


Gly Lys Ala Leu Ile His Cys Trp Thr Asp Pro Gly Gln Pro Leu Gly 
        35                  40                  45              


Glu Gln Gln Arg Val Arg Arg Gln Arg Thr Glu Thr Ser Glu Pro Thr 
    50                  55                  60                  


Met Arg Leu His Arg Leu Arg Ala Arg Leu Ser Ala Val Ala Cys Gly 
65                  70                  75                  80  


Leu Leu Leu Leu Leu Val Arg Gly Gln Gly Gln Asp Ser Ala Ser Pro 
                85                  90                  95      


Ile Arg Thr Thr His Thr Gly Gln Val Leu Gly Ser Leu Val His Val 
            100                 105                 110         


Lys Gly Ala Asn Ala Gly Val Gln Thr Phe Leu Gly Ile Pro Phe Ala 
        115                 120                 125             


Lys Pro Pro Leu Gly Pro Leu Arg Phe Ala Pro Pro Glu Pro Pro Glu 
    130                 135                 140                 


Ser Trp Ser Gly Val Arg Asp Gly Thr Thr His Pro Ala Met Cys Leu 
145                 150                 155                 160 


Gln Asp Leu Thr Ala Val Glu Ser Glu Phe Leu Ser Gln Phe Asn Met 
                165                 170                 175     


Thr Phe Pro Ser Asp Ser Met Ser Glu Asp Cys Leu Tyr Leu Ser Ile 
            180                 185                 190         


Tyr Thr Pro Ala His Ser His Glu Gly Ser Asn Leu Pro Val Met Val 
        195                 200                 205             


Trp Ile His Gly Gly Ala Leu Val Phe Gly Met Ala Ser Leu Tyr Asp 
    210                 215                 220                 


Gly Ser Met Leu Ala Ala Leu Glu Asn Val Val Val Val Ile Ile Gln 
225                 230                 235                 240 


Tyr Arg Leu Gly Val Leu Gly Phe Phe Ser Thr Gly Asp Lys His Ala 
                245                 250                 255     


Thr Gly Asn Trp Gly Tyr Leu Asp Gln Val Ala Ala Leu Arg Trp Val 
            260                 265                 270         


Gln Gln Asn Ile Ala His Phe Gly Gly Asn Pro Asp Arg Val Thr Ile 
        275                 280                 285             


Phe Gly Glu Ser Ala Gly Gly Thr Ser Val Ser Ser Leu Val Val Ser 
    290                 295                 300                 


Pro Ile Ser Gln Gly Leu Phe His Gly Ala Ile Met Glu Ser Gly Val 
305                 310                 315                 320 


Ala Leu Leu Pro Gly Leu Ile Ala Ser Ser Ala Asp Val Ile Ser Thr 
                325                 330                 335     


Val Val Ala Asn Leu Ser Ala Cys Asp Gln Val Asp Ser Glu Ala Leu 
            340                 345                 350         


Val Gly Cys Leu Arg Gly Lys Ser Lys Glu Glu Ile Leu Ala Ile Asn 
        355                 360                 365             


Lys Pro Phe Lys Met Ile Pro Gly Val Val Asp Gly Val Phe Leu Pro 
    370                 375                 380                 


Arg His Pro Gln Glu Leu Leu Ala Ser Ala Asp Phe Gln Pro Val Pro 
385                 390                 395                 400 


Ser Ile Val Gly Val Asn Asn Asn Glu Phe Gly Trp Leu Ile Pro Lys 
                405                 410                 415     


Val Met Arg Ile Tyr Asp Thr Gln Lys Glu Met Asp Arg Glu Ala Ser 
            420                 425                 430         


Gln Ala Ala Leu Gln Lys Met Leu Thr Leu Leu Met Leu Pro Pro Thr 
        435                 440                 445             


Phe Gly Asp Leu Leu Arg Glu Glu Tyr Ile Gly Asp Asn Gly Asp Pro 
    450                 455                 460                 


Gln Thr Leu Gln Ala Gln Phe Gln Glu Met Met Ala Asp Ser Met Phe 
465                 470                 475                 480 


Val Ile Pro Ala Leu Gln Val Ala His Phe Gln Cys Ser Arg Ala Pro 
                485                 490                 495     


Val Tyr Phe Tyr Glu Phe Gln His Gln Pro Ser Trp Leu Lys Asn Ile 
            500                 505                 510         


Arg Pro Pro His Met Lys Ala Asp His Gly Asp Glu Leu Pro Phe Val 
        515                 520                 525             


Phe Arg Ser Phe Phe Gly Gly Asn Tyr Ile Lys Phe Thr Glu Glu Glu 
    530                 535                 540                 


Glu Gln Leu Ser Arg Lys Met Met Lys Tyr Trp Ala Asn Phe Ala Arg 
545                 550                 555                 560 


Asn Gly Asn Pro Asn Gly Glu Gly Leu Pro His Trp Pro Leu Phe Asp 
                565                 570                 575     


Gln Glu Glu Gln Tyr Leu Gln Leu Asn Leu Gln Pro Ala Val Gly Arg 
            580                 585                 590         


Ala Leu Lys Ala His Arg Leu Gln Phe Trp Lys Lys Ala Leu Pro Gln 
        595                 600                 605             


Lys Ile Gln Glu Leu Glu Glu Pro Glu Glu Arg His Thr Glu Leu 
    610                 615                 620             


<210>  2058
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CES3__Homo_sapiens__NP_001172105

<400>  2058

Met Glu Gln Met Ser Arg Glu Asp Met Leu Ala Ile Ser Thr Pro Val 
1               5                   10                  15      


Leu Thr Ser Leu Asp Val Pro Pro Glu Met Met Pro Thr Val Ile Asp 
            20                  25                  30          


Glu Tyr Leu Gly Ser Asn Ser Asp Ala Gln Ala Lys Cys Gln Ala Phe 
        35                  40                  45              


Gln Glu Phe Met Gly Asp Val Phe Ile Asn Val Pro Thr Val Ser Phe 
    50                  55                  60                  


Ser Arg Tyr Leu Arg Asp Ser Gly Ser Pro Val Phe Phe Tyr Glu Phe 
65                  70                  75                  80  


Gln His Arg Pro Ser Ser Phe Ala Lys Ile Lys Pro Ala Trp Val Lys 
                85                  90                  95      


Ala Asp His Gly Ala Glu Gly Ala Phe Val Phe Gly Gly Pro Phe Leu 
            100                 105                 110         


Met Asp Glu Ser Ser Arg Leu Ala Phe Pro Glu Ala Thr Glu Glu Glu 
        115                 120                 125             


Lys Gln Leu Ser Leu Thr Met Met Ala Gln Trp Thr His Phe Ala Arg 
    130                 135                 140                 


Thr Gly Asp Pro Asn Ser Lys Ala Leu Pro Pro Trp Pro Gln Phe Asn 
145                 150                 155                 160 


Gln Ala Glu Gln Tyr Leu Glu Ile Asn Pro Val Pro Arg Ala Gly Gln 
                165                 170                 175     


Lys Phe Arg Glu Ala Trp Met Gln Phe Trp Ser Glu Thr Leu Pro Ser 
            180                 185                 190         


Lys Ile Gln Gln Trp His Gln Lys Gln Lys Asn Arg Lys Ala Gln Glu 
        195                 200                 205             


Asp Leu 
    210 


<210>  2059
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CETN1__Homo_sapiens__NP_004057

<400>  2059

Met Ala Ser Gly Phe Lys Lys Pro Ser Ala Ala Ser Thr Gly Gln Lys 
1               5                   10                  15      


Arg Lys Val Ala Pro Lys Pro Glu Leu Thr Glu Asp Gln Lys Gln Glu 
            20                  25                  30          


Val Arg Glu Ala Phe Asp Leu Phe Asp Val Asp Gly Ser Gly Thr Ile 
        35                  40                  45              


Asp Ala Lys Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Glu Pro 
    50                  55                  60                  


Arg Lys Glu Glu Met Lys Lys Met Ile Ser Glu Val Asp Arg Glu Gly 
65                  70                  75                  80  


Thr Gly Lys Ile Ser Phe Asn Asp Phe Leu Ala Val Met Thr Gln Lys 
                85                  90                  95      


Met Ser Glu Lys Asp Thr Lys Glu Glu Ile Leu Lys Ala Phe Arg Leu 
            100                 105                 110         


Phe Asp Asp Asp Glu Thr Gly Lys Ile Ser Phe Lys Asn Leu Lys Arg 
        115                 120                 125             


Val Ala Asn Glu Leu Gly Glu Asn Leu Thr Asp Glu Glu Leu Gln Glu 
    130                 135                 140                 


Met Ile Asp Glu Ala Asp Arg Asp Gly Asp Gly Glu Val Asn Glu Glu 
145                 150                 155                 160 


Glu Phe Leu Arg Ile Met Lys Lys Thr Ser Leu Tyr 
                165                 170         


<210>  2060
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CETN2__Homo_sapiens__NP_004335

<400>  2060

Met Ala Ser Asn Phe Lys Lys Ala Asn Met Ala Ser Ser Ser Gln Arg 
1               5                   10                  15      


Lys Arg Met Ser Pro Lys Pro Glu Leu Thr Glu Glu Gln Lys Gln Glu 
            20                  25                  30          


Ile Arg Glu Ala Phe Asp Leu Phe Asp Ala Asp Gly Thr Gly Thr Ile 
        35                  40                  45              


Asp Val Lys Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Glu Pro 
    50                  55                  60                  


Lys Lys Glu Glu Ile Lys Lys Met Ile Ser Glu Ile Asp Lys Glu Gly 
65                  70                  75                  80  


Thr Gly Lys Met Asn Phe Gly Asp Phe Leu Thr Val Met Thr Gln Lys 
                85                  90                  95      


Met Ser Glu Lys Asp Thr Lys Glu Glu Ile Leu Lys Ala Phe Lys Leu 
            100                 105                 110         


Phe Asp Asp Asp Glu Thr Gly Lys Ile Ser Phe Lys Asn Leu Lys Arg 
        115                 120                 125             


Val Ala Lys Glu Leu Gly Glu Asn Leu Thr Asp Glu Glu Leu Gln Glu 
    130                 135                 140                 


Met Ile Asp Glu Ala Asp Arg Asp Gly Asp Gly Glu Val Ser Glu Gln 
145                 150                 155                 160 


Glu Phe Leu Arg Ile Met Lys Lys Thr Ser Leu Tyr 
                165                 170         


<210>  2061
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CETN3__Homo_sapiens__NP_004356

<400>  2061

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15      


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30          


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45              


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60                  


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80  


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95      


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110         


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125             


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140                 


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu Phe Ile 
145                 150                 155                 160 


Ala Ile Met Thr Gly Asp Ile 
                165         


<210>  2062
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CETP__Homo_sapiens__NP_000069

<400>  2062

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile 
            20                  25                  30          


Thr Lys Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile 
        35                  40                  45              


Gln Thr Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys 
    50                  55                  60                  


Ala Met Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln 
65                  70                  75                  80  


Ile Ser His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala 
                85                  90                  95      


Lys Ser Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly 
            100                 105                 110         


Thr Leu Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln 
        115                 120                 125             


Ser Ile Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr 
    130                 135                 140                 


Gln Leu Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys 
145                 150                 155                 160 


Tyr Leu Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu 
                165                 170                 175     


Pro Gly Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu 
            180                 185                 190         


Lys Leu Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser 
        195                 200                 205             


Asn Ile Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser 
    210                 215                 220                 


Asp Gly Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile 
225                 230                 235                 240 


Thr Ala Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys 
                245                 250                 255     


Asn Val Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu 
            260                 265                 270         


Gly Asp Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His 
        275                 280                 285             


Ser Leu Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu 
    290                 295                 300                 


Met Gly Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr 
305                 310                 315                 320 


Asn Gln Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala 
                325                 330                 335     


Gln Val Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn 
            340                 345                 350         


Lys Gly Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro 
        355                 360                 365             


Arg Pro Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile 
    370                 375                 380                 


Val Thr Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser 
385                 390                 395                 400 


Leu Leu Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu 
                405                 410                 415     


Ser Ser Ser Glu Ser Val Gln Ser Phe Leu Gln Ser Met Ile Thr Ala 
            420                 425                 430         


Val Gly Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala 
        435                 440                 445             


Leu Met Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu 
    450                 455                 460                 


Ile Ile Thr Arg Asp Gly Phe Leu Leu Leu Gln Met Asp Phe Gly Phe 
465                 470                 475                 480 


Pro Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu Ser 
                485                 490             


<210>  2063
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP126__Homo_sapiens__NP_001013647

<400>  2063

Met Ala Thr Asn Tyr Ser Ala Asn Gln Tyr Glu Lys Ala Phe Ser Ser 
1               5                   10                  15      


Lys Tyr Leu Gln Asn Trp Ser Pro Thr Lys Pro Thr Lys Glu Ser Ile 
            20                  25                  30          


Ser Ser His Glu Gly Tyr Thr Gln Ile Ile Ala Asn Asp Arg Gly His 
        35                  40                  45              


Leu Leu Pro Ser Val Pro Arg Ser Lys Ala Asn Pro Trp Gly Ser Phe 
    50                  55                  60                  


Met Gly Thr Trp Gln Met Pro Leu Lys Ile Pro Pro Ala Arg Val Thr 
65                  70                  75                  80  


Leu Thr Ser Arg Thr Thr Ala Gly Ala Ala Ser Leu Thr Lys Trp Ile 
                85                  90                  95      


Gln Lys Asn Pro Asp Leu Leu Lys Ala Ser Asn Gly Leu Cys Pro Glu 
            100                 105                 110         


Ile Leu Gly Lys Pro His Asp Pro Asp Ser Gln Lys Lys Leu Arg Lys 
        115                 120                 125             


Lys Ser Ile Thr Lys Thr Val Gln Gln Ala Arg Ser Pro Thr Ile Ile 
    130                 135                 140                 


Pro Ser Ser Pro Ala Ala Asn Leu Asn Ser Pro Asp Glu Leu Gln Ser 
145                 150                 155                 160 


Ser His Pro Ser Ala Gly His Thr Pro Gly Pro Gln Arg Pro Ala Lys 
                165                 170                 175     


Ser 
    


<210>  2064
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP36__Homo_sapiens__NP_001269690

<400>  2064

Met Ala Ala Glu Glu Glu Asp Glu Val Glu Trp Val Val Glu Ser Ile 
1               5                   10                  15      


Ala Gly Phe Leu Arg Gly Pro Asp Trp Ser Ile Pro Ile Leu Asp Phe 
            20                  25                  30          


Val Glu Gln Lys Cys Glu Val Asn Cys Lys Gly Gly His Val Ile Thr 
        35                  40                  45              


Pro Gly Ser Pro Glu Pro Val Ile Leu Val Ala Cys Val Pro Leu Val 
    50                  55                  60                  


Phe Asp Asp Glu Glu Glu Ser Lys Leu Thr Tyr Thr Glu Ile His Gln 
65                  70                  75                  80  


Glu Tyr Lys Glu Leu Val Glu Lys Leu Leu Glu Gly Tyr Leu Lys Glu 
                85                  90                  95      


Ile Gly Ile Asn Glu Asp Gln Phe Gln Glu Ala Cys Thr Ser Pro Leu 
            100                 105                 110         


Ala Lys Thr His Thr Ser Gln Ala Ile Leu Gln Pro Val Leu Ala Ala 
        115                 120                 125             


Glu Asp Phe Thr Ile Phe Lys Ala Met Met Val Gln Lys Asn Ile Glu 
    130                 135                 140                 


Met Gln Leu Gln Ala Ile Arg Ile Ile Gln Glu Arg Asn Gly Val Leu 
145                 150                 155                 160 


Pro Asp Cys Leu Thr Asp Gly Ser Asp Val Val Ser Asp Leu Glu His 
                165                 170                 175     


Glu Glu Met Lys Ile Leu Arg Glu Val Leu Arg Lys Ser Lys Glu Glu 
            180                 185                 190         


Tyr Asp Gln Glu Glu Glu Arg Lys Arg Lys Lys Gln Leu Ser Glu Ala 
        195                 200                 205             


Lys Thr Glu Glu Pro Thr Val His Ser Ser Glu Ala Ala Ile Met Asn 
    210                 215                 220                 


Asn Ser Gln Gly Asp Gly Glu His Phe Ala His Pro Pro Ser Glu Val 
225                 230                 235                 240 


Lys Met His Phe Ala Asn Gln Ser Ile Glu Pro Leu Gly Arg Lys Val 
                245                 250                 255     


Glu Arg Ser Glu Thr Ser Ser Leu Pro Gln Lys Asp Leu Lys Ile Pro 
            260                 265                 270         


Gly Leu Glu His Ala Ser Ile Glu Gly Pro Ile Ala Asn Leu Ser Val 
        275                 280                 285             


Leu Gly Thr Glu Glu Leu Arg Gln Arg Glu His Tyr Leu Lys Gln Lys 
    290                 295                 300                 


Arg Asp Lys Leu Met Ser Met Arg Lys Asp Met Arg Thr Lys Gln Ile 
305                 310                 315                 320 


Gln Asn Met Glu Gln Lys Gly Lys Pro Thr Gly Glu Val Glu Glu Met 
                325                 330                 335     


Thr Glu Lys Pro Glu Met Thr Ala Glu Glu Lys Gln Thr Leu Leu Lys 
            340                 345                 350         


Arg Arg Leu Leu Ala Glu Lys Leu Lys Glu Glu Val Ile Asn Lys 
        355                 360                 365         


<210>  2065
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP44__Homo_sapiens__NP_060808

<400>  2065

Met Lys Glu Pro Asp Asp Gln Asp Thr Asp Gly Glu Lys Ser Val Thr 
1               5                   10                  15      


Ser Lys Ser Asp Gly Lys Lys Ser Leu Arg Ser Ser Lys Ser Glu Ser 
            20                  25                  30          


Arg Ser Pro Val Gln Glu Asp Asn Thr Phe Leu Glu Asp Asp Thr Asp 
        35                  40                  45              


Glu Thr Phe Thr Lys Gly Glu Gly Ser Tyr Leu Glu Glu Asp Ser Asp 
    50                  55                  60                  


Glu Glu Arg Leu Glu Gly Ser Leu Ser Ser Phe Gln Tyr Gly Asp Leu 
65                  70                  75                  80  


Gln Ser Thr Thr Val Pro Gln Gln Thr Pro Ala Pro Ala Val Glu Glu 
                85                  90                  95      


Ala Glu Glu Glu Val Lys Lys Lys Ile Ser Glu Ser Phe Phe Tyr Asp 
            100                 105                 110         


Tyr Met Glu Leu Ala Ser Met Pro Phe Val Thr Leu Asp Ser Asn Ile 
        115                 120                 125             


Pro Leu Asp Leu Leu Thr Leu Val His Ser Phe Gly Tyr Asp Cys Arg 
    130                 135                 140                 


Lys Arg Ala Asn Leu Gln Leu Leu Asp Asp Ser Ile Ala Ile Tyr Ile 
145                 150                 155                 160 


Ala Gly Asn Gln Leu Ile Phe Leu Asn Leu Lys Thr Lys Glu Gln Ile 
                165                 170                 175     


Tyr Leu Arg Ser Ser Ser Gly Glu Gly Ile Gly Val Ile Gly Val His 
            180                 185                 190         


Pro His Lys Thr Tyr Phe Thr Val Ala Glu Lys Gly Ser Phe Pro Asp 
        195                 200                 205             


Ile Ile Ile Tyr Glu Tyr Pro Ser Leu Arg Pro Tyr Arg Val Leu Arg 
    210                 215                 220                 


Asp Gly Thr Glu Lys Gly Tyr Ala Tyr Val Asp Phe Asn Tyr Ser Gly 
225                 230                 235                 240 


Asn Leu Leu Ala Ser Val Gly Ser Asn Pro Asp Tyr Thr Leu Thr Ile 
                245                 250                 255     


Trp Asn Trp Lys Glu Glu Gln Pro Ile Leu Arg Thr Lys Ala Phe Ser 
            260                 265                 270         


Gln Glu Val Phe Lys Val Thr Phe Asn Pro Asp Lys Glu Glu Gln Leu 
        275                 280                 285             


Thr Thr Ser Gly Ser Gly His Ile Lys Phe Trp Glu Met Ala Phe Thr 
    290                 295                 300                 


Phe Thr Gly Leu Lys Leu Gln Gly Ser Leu Gly Arg Phe Gly Lys Thr 
305                 310                 315                 320 


Ile Thr Thr Asp Ile Glu Gly Tyr Met Glu Leu Pro Asp Gly Lys Val 
                325                 330                 335     


Leu Ser Gly Ser Glu Trp Gly Asn Met Leu Leu Trp Glu Gly Gly Leu 
            340                 345                 350         


Ile Lys Val Glu Leu Cys Arg Gly Thr Ser Lys Ser Cys His Asn Gly 
        355                 360                 365             


Pro Ile Asn Gln Ile Met Leu Tyr Glu Gly Glu Val Ile Thr Val Gly 
    370                 375                 380                 


Ser Asp Gly Tyr Val Arg Ile Trp Asp Phe Glu Thr Ile Asp Thr Ala 
385                 390                 395                 400 


Asp Val Ile Asp Glu Thr Gly Leu Leu Glu Ile Glu Pro Ile Asn Glu 
                405                 410                 415     


Leu Gln Val Asp Lys Asn Val Asn Leu Phe Ser Met Ile Lys Met Asn 
            420                 425                 430         


Glu Thr Gly Asn Asn Phe Trp Leu Ala Gln Asp Ala Asn Gly Ala Ile 
        435                 440                 445             


Trp Lys Leu Asp Leu Ser Phe Ser Asn Ile Thr Gln Asp Pro Glu Cys 
    450                 455                 460                 


Leu Phe Ser Phe His Ser Gly Ala Ile Glu Ala Val Ala Val Ser Pro 
465                 470                 475                 480 


Leu Thr Tyr Leu Met Ala Thr Thr Ala Leu Asp Cys Ser Val Arg Ile 
                485                 490                 495     


Tyr Asp Phe Ala Ser Lys Thr Pro Leu Ala Gln Met Lys Phe Lys Gln 
            500                 505                 510         


Gly Gly Thr Ala Leu Val Trp Val Pro Arg Met Val Asn Phe Thr Gly 
        515                 520                 525             


Ala Gln Ile Ile Val Gly Phe Glu Asp Gly Val Val Arg Ile Leu Glu 
    530                 535                 540                 


Leu Tyr Asp Pro Lys Gly Leu Thr Ile Phe Ala Gly Arg Lys Lys Ile 
545                 550                 555                 560 


Leu Asp Ala Asp Ile Gln Leu Lys Gln Val Phe Lys Pro His Thr Ala 
                565                 570                 575     


Cys Val Thr Ala Leu Ala Tyr Glu Arg Asp Gly Glu Ile Leu Ala Thr 
            580                 585                 590         


Gly Ser Lys Asp Gln Thr Val Phe Phe Phe Glu Val Glu Arg Asp Tyr 
        595                 600                 605             


Lys Pro Ile Gly Tyr Ile Asn Thr Pro Gly Pro Val Cys Gln Leu Met 
    610                 615                 620                 


Trp Ser Pro Met Ser His Pro Glu Ser Thr Leu Leu Ile Ile Cys Glu 
625                 630                 635                 640 


Asn Gly Tyr Ile Leu Glu Ala Pro Leu Pro Thr Ile Lys Gln Glu Glu 
                645                 650                 655     


Asp Asp His Asp Val Val Ser Tyr Glu Ile Lys Asp Met Cys Ile Lys 
            660                 665                 670         


Cys Phe His Phe Ser Ser Val Lys Ser Lys Ile Leu Arg Leu Ile Glu 
        675                 680                 685             


Ile Glu Lys Arg Glu Arg Gln Arg Glu Leu Lys Glu Lys Ile Arg Glu 
    690                 695                 700                 


Glu Arg Arg Asn Lys Leu Ala Ala Glu Met Gly Glu Asp Gly Glu Lys 
705                 710                 715                 720 


Glu Phe Gln Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu 
                725                 730                 735     


Glu Pro Leu Pro Glu Ile Phe Ile Pro Ser Thr Pro Ser Pro Ile Leu 
            740                 745                 750         


Cys Gly Phe Tyr Ser Glu Pro Gly Lys Phe Trp Val Ser Leu Gly Gly 
        755                 760                 765             


Tyr Asp Ser Gly Phe Leu Tyr His Cys Glu Phe Pro Pro Cys Asp Glu 
    770                 775                 780                 


Ser Ser Asp Phe Lys Glu Gln Lys Asp Glu Pro Ile Asp Val Arg Tyr 
785                 790                 795                 800 


Leu Ala Asp Thr Glu Asp Asn Pro Ile Gln Thr Ile Thr Phe Asn Ile 
                805                 810                 815     


Asn Lys Val Met Met Phe Cys Gly Met Lys Asn Gly Ala Ile Arg Val 
            820                 825                 830         


Tyr Val Leu Asn Gln Asn Asp Pro Ser Leu Thr Ser Leu Val Asp Tyr 
        835                 840                 845             


Trp His Phe Asn Met His Asp Asn Asn Tyr Gly Cys Ile Lys Ser Ile 
    850                 855                 860                 


Ala Asn Ser Phe Asp Asp Arg Phe Leu Val Thr Ala Gly Ala Asp Gly 
865                 870                 875                 880 


Asn Ile Phe Val Phe Asn Ile Phe Ser Glu Phe Met Leu Arg Lys Asp 
                885                 890                 895     


Met Lys Ala Lys Val Pro Ser Pro Arg Phe Gly Ile Glu Thr Glu Pro 
            900                 905                 910         


Ile Pro Glu Asp Ile Glu Asp Pro Lys Ala Tyr Ser Ile Glu Asn Ala 
        915                 920                 925             


Arg Arg Lys Arg Glu His Asp Lys Leu Met Lys Glu Val Gly Glu Ile 
    930                 935                 940                 


Lys Ala Arg Lys Arg Glu Gln Ile Lys Ala Leu Arg Ser Glu Phe Cys 
945                 950                 955                 960 


Asn Leu Leu Glu Met Asn Glu Lys Leu Pro Lys His Met Gln Phe Lys 
                965                 970                 975     


Arg Thr Val Ser Leu Ile 
            980         


<210>  2066
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP52__Homo_sapiens__NP_001074025

<400>  2066

Met Asp Asn Lys Ile Ser Pro Glu Ala Gln Val Ala Glu Leu Glu Leu 
1               5                   10                  15      


Asp Ala Val Ile Gly Phe Asn Asp Ile Ile Leu Trp Asp Tyr Lys Asn 
            20                  25                  30          


Arg Glu Leu Leu Ala Arg Leu Ser Leu His Lys Gly Lys Ile Glu Ala 
        35                  40                  45              


Leu Ala Phe Ser Pro Asn Asp Leu Tyr Leu Val Ser Leu Gly Gly Pro 
    50                  55                  60                  


Asp Asp Gly Ser Val Val Val Trp Ser Ile Ala Lys Arg Asp Ala Ile 
65                  70                  75                  80  


Cys Gly Ser Pro Ala Ala Gly Leu Asn Val Gly Asn Ala Thr Asn Val 
                85                  90                  95      


Ile Phe Ser Arg Cys Arg Asp Glu Met Phe Met Thr Ala Gly Asn Gly 
            100                 105                 110         


Thr Ile Arg Val Trp Glu Leu Asp Leu Pro Asn Arg Lys Ile Trp Pro 
        115                 120                 125             


Thr Glu Cys Gln Thr Gly Gln Leu Lys Arg Ile Val Met Ser Ile Gly 
    130                 135                 140                 


Val Asp Asp Asp Asp Ser Phe Phe Tyr Leu Gly Thr Thr Thr Gly Asp 
145                 150                 155                 160 


Ile Leu Lys Met Asn Pro Arg Thr Lys Leu Leu Thr Asp Val Gly Pro 
                165                 170                 175     


Ala Lys Asp Lys Phe Ser Leu Gly Val Ser Ala Ile Arg Cys Leu Lys 
            180                 185                 190         


Met Gly Gly Leu Leu Val Gly Ser Gly Ala Gly Leu Leu Val Phe Cys 
        195                 200                 205             


Lys Ser Pro Gly Tyr Lys Pro Ile Lys Lys Ile Gln Leu Gln Gly Gly 
    210                 215                 220                 


Ile Thr Ser Ile Thr Leu Arg Gly Glu Gly His Gln Phe Leu Val Gly 
225                 230                 235                 240 


Thr Glu Glu Ser His Ile Tyr Arg Val Ser Phe Thr Asp Phe Lys Glu 
                245                 250                 255     


Thr Leu Ile Ala Thr Cys His Phe Asp Ala Val Glu Asp Ile Val Phe 
            260                 265                 270         


Pro Phe Gly Thr Ala Glu Leu Phe Ala Thr Cys Ala Lys Lys Asp Ile 
        275                 280                 285             


Arg Val Trp His Thr Ser Ser Asn Arg Glu Leu Leu Arg Ile Thr Val 
    290                 295                 300                 


Pro Asn Met Thr Cys His Gly Ile Asp Phe Met Arg Asp Gly Lys Ser 
305                 310                 315                 320 


Ile Ile Ser Ala Trp Asn Asp Gly Lys Ile Arg Ala Phe Ala Pro Glu 
                325                 330                 335     


Thr Gly Arg Leu Met Tyr Val Ile Asn Asn Ala His Arg Ile Gly Val 
            340                 345                 350         


Thr Ala Ile Ala Thr Thr Ser Asp Cys Lys Arg Val Ile Ser Gly Gly 
        355                 360                 365             


Gly Glu Gly Glu Val Arg Val Trp Gln Ile Gly Cys Gln Thr Gln Lys 
    370                 375                 380                 


Leu Glu Glu Ala Leu Lys Glu His Lys Ser Ser Val Ser Cys Ile Arg 
385                 390                 395                 400 


Val Lys Arg Asn Asn Glu Glu Cys Val Thr Ala Ser Thr Asp Gly Thr 
                405                 410                 415     


Cys Ile Ile Trp Asp Leu Val Arg Leu Arg Arg Asn Gln Met Ile Leu 
            420                 425                 430         


Ala Asn Thr Leu Phe Gln Cys Val Cys Tyr His Pro Glu Glu Phe Gln 
        435                 440                 445             


Ile Ile Thr Ser Gly Thr Asp Arg Lys Ile Ala Tyr Trp Glu Val Phe 
    450                 455                 460                 


Asp Gly Thr Val Ile Arg Glu Leu Glu Gly Ser Leu Ser Gly Ser Ile 
465                 470                 475                 480 


Asn Gly Met Asp Ile Thr Gln Glu Gly Val His Phe Val Thr Gly Gly 
                485                 490                 495     


Asn Asp His Leu Val Lys Val Trp Asp Tyr Asn Glu Gly Glu Val Thr 
            500                 505                 510         


His Val Gly Val Gly His Ser Gly Asn Ile Thr Arg Ile Arg Ile Ser 
        515                 520                 525             


Pro Gly Asn Gln Tyr Ile Val Ser Val Ser Ala Asp Gly Ala Ile Leu 
    530                 535                 540                 


Arg Trp Lys Tyr Pro Tyr Thr Ser 
545                 550         


<210>  2067
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP53__Homo_sapiens__NP_659457

<400>  2067

Met Tyr Ser Gln Arg Phe Gly Thr Val Gln Arg Glu Val Lys Gly Pro 
1               5                   10                  15      


Thr Pro Lys Val Val Ile Val Arg Ser Lys Pro Pro Lys Gly Gln Gly 
            20                  25                  30          


Ala Glu His His Leu Glu Arg Ile Arg Arg Ser His Gln Lys His Asn 
        35                  40                  45              


Ala Ile Leu Ala Ser Ile Lys Ser Ser Glu Arg Asp Arg Leu Lys Ala 
    50                  55                  60                  


Glu Trp Asp Gln His Asn Asp Cys Lys Ile Leu Asp Ser Leu Val Arg 
65                  70                  75                  80  


Ala Arg Ile Lys Asp Ala Val Gln Gly Phe Ile Ile Asn Ile Glu Glu 
                85                  90                  95      


Arg Arg Asn Lys Leu Arg Glu Leu Leu Ala Leu Glu Glu Asn Glu Tyr 
            100                 105                 110         


Phe Thr Glu Met Gln Leu Lys Lys Glu Thr Ile Glu Glu Lys Lys Asp 
        115                 120                 125             


Arg Met Arg Glu Lys Thr Lys Leu Leu Lys Glu Lys Asn Glu Lys Glu 
    130                 135                 140                 


Arg Gln Asp Phe Val Ala Glu Lys Leu Asp Gln Gln Phe Arg Glu Arg 
145                 150                 155                 160 


Cys Glu Glu Leu Arg Val Glu Leu Leu Ser Ile His Gln Lys Lys Val 
                165                 170                 175     


Cys Glu Glu Arg Lys Ala Gln Ile Ala Phe Asn Glu Glu Leu Ser Arg 
            180                 185                 190         


Gln Lys Leu Val Glu Glu Gln Met Phe Ser Lys Leu Trp Glu Glu Asp 
        195                 200                 205             


Arg Leu Ala Lys Glu Lys Arg Glu Ala Gln Glu Ala Arg Arg Gln Lys 
    210                 215                 220                 


Glu Leu Met Glu Asn Thr Arg Leu Gly Leu Asn Ala Gln Ile Thr Ser 
225                 230                 235                 240 


Ile Lys Ala Gln Arg Gln Ala Thr Gln Leu Leu Lys Glu Glu Glu Ala 
                245                 250                 255     


Arg Leu Val Glu Ser Asn Asn Ala Gln Ile Lys His Glu Asn Glu Gln 
            260                 265                 270         


Asp Met Leu Lys Lys Gln Lys Ala Lys Gln Glu Thr Arg Thr Ile Leu 
        275                 280                 285             


Gln Lys Ala Leu Gln Glu Arg Ile Glu His Ile Gln Gln Glu Tyr Arg 
    290                 295                 300                 


Asp Glu Gln Asp Leu Asn Met Lys Leu Val Gln Arg Ala Leu Gln Asp 
305                 310                 315                 320 


Leu Gln Glu Glu Ala Asp Lys Lys Lys Gln Lys Arg Glu Asp Met Ile 
                325                 330                 335     


Arg Glu Gln Lys Ile Tyr His Lys Tyr Leu Ala Gln Arg Arg Glu Glu 
            340                 345                 350         


Glu Lys Ala Gln Glu Lys Glu Phe Asp Arg Ile Leu Glu Glu Asp Lys 
        355                 360                 365             


Ala Lys Lys Leu Ala Glu Lys Asp Lys Glu Leu Arg Leu Glu Lys Glu 
    370                 375                 380                 


Ala Arg Arg Gln Leu Val Asp Glu Val Met Cys Thr Arg Lys Leu Gln 
385                 390                 395                 400 


Val Gln Glu Lys Leu Gln Arg Glu Ala Lys Glu Gln Glu Glu Arg Ala 
                405                 410                 415     


Met Glu Gln Lys His Ile Asn Glu Ser Leu Lys Glu Leu Asn Cys Glu 
            420                 425                 430         


Glu Lys Glu Asn Phe Ala Arg Arg Gln Arg Leu Ala Gln Glu Tyr Arg 
        435                 440                 445             


Lys Gln Leu Gln Met Gln Ile Ala Tyr Gln Gln Gln Ser Gln Glu Ala 
    450                 455                 460                 


Glu Lys Glu Glu Lys Arg Arg Glu Phe Glu Ala Gly Val Ala Ala Asn 
465                 470                 475                 480 


Lys Met Cys Leu Asp Lys Val Gln Glu Val Leu Ser Thr His Gln Val 
                485                 490                 495     


Leu Pro Gln Asn Ile His Pro Met Arg Lys Ala Cys Pro Ser Lys Leu 
            500                 505                 510         


Pro Pro 
        


<210>  2068
<211>  1121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP57__Homo_sapiens__XP_011539101

<400>  2068

Met Ser Ala Val Val Ala Gln Thr Leu His Val Phe Gly Leu Arg Ser 
1               5                   10                  15      


His Val Ala Asn Asn Ile Phe Tyr Phe Asp Glu Gln Ile Ile Ile Phe 
            20                  25                  30          


Pro Ser Gly Asn His Cys Val Lys Tyr Asn Val Asp Gln Lys Trp Gln 
        35                  40                  45              


Lys Phe Ile Pro Gly Ser Glu Lys Ser Gln Gly Met Leu Ala Leu Ser 
    50                  55                  60                  


Ile Ser Pro Asn Arg Arg Tyr Leu Ala Ile Ser Glu Thr Val Gln Glu 
65                  70                  75                  80  


Lys Pro Ala Ile Thr Ile Tyr Glu Leu Ser Ser Ile Pro Cys Arg Lys 
                85                  90                  95      


Arg Lys Val Leu Asn Asn Phe Asp Phe Gln Val Gln Lys Phe Ile Ser 
            100                 105                 110         


Met Ala Phe Ser Pro Asp Ser Lys Tyr Leu Leu Ala Gln Thr Ser Pro 
        115                 120                 125             


Pro Glu Ser Asn Leu Val Tyr Trp Leu Trp Glu Lys Gln Lys Val Met 
    130                 135                 140                 


Ala Ile Val Arg Ile Asp Thr Gln Asn Asn Pro Val Tyr Gln Val Ser 
145                 150                 155                 160 


Phe Ser Pro Gln Asp Asn Thr Gln Val Cys Val Thr Gly Asn Gly Met 
                165                 170                 175     


Phe Lys Leu Leu Arg Phe Ala Glu Gly Thr Leu Lys Gln Thr Ser Phe 
            180                 185                 190         


Gln Arg Gly Glu Pro Gln Asn Tyr Leu Ala His Thr Trp Val Ala Asp 
        195                 200                 205             


Asp Lys Ile Val Val Gly Thr Asp Thr Gly Lys Leu Phe Leu Phe Glu 
    210                 215                 220                 


Ser Gly Asp Gln Arg Trp Glu Thr Ser Ile Met Val Lys Glu Pro Thr 
225                 230                 235                 240 


Asn Gly Ser Lys Ser Leu Asp Val Ile Gln Glu Ser Glu Ser Leu Ile 
                245                 250                 255     


Glu Phe Pro Pro Val Ser Ser Pro Leu Pro Ser Tyr Glu Gln Met Val 
            260                 265                 270         


Ala Ala Ser Ser His Ser Gln Met Ser Met Pro Gln Val Phe Ala Ile 
        275                 280                 285             


Ala Ala Tyr Ser Lys Gly Phe Ala Cys Ser Ala Gly Pro Gly Arg Val 
    290                 295                 300                 


Leu Leu Phe Glu Lys Met Glu Glu Lys Asp Phe Tyr Arg Glu Ser Arg 
305                 310                 315                 320 


Glu Ile Arg Ile Pro Val Asp Pro Gln Ser Asn Asp Pro Ser Gln Ser 
                325                 330                 335     


Asp Lys Gln Asp Val Leu Cys Leu Cys Phe Ser Pro Ser Glu Glu Thr 
            340                 345                 350         


Leu Val Ala Ser Thr Ser Lys Asn Gln Leu Tyr Ser Ile Thr Met Ser 
        355                 360                 365             


Leu Thr Glu Ile Ser Lys Gly Glu Pro Ala His Phe Glu Tyr Leu Met 
    370                 375                 380                 


Tyr Pro Leu His Ser Ala Pro Ile Thr Gly Leu Ala Thr Cys Ile Arg 
385                 390                 395                 400 


Lys Pro Leu Ile Ala Thr Cys Ser Leu Asp Arg Ser Ile Arg Leu Trp 
                405                 410                 415     


Asn Tyr Glu Thr Asn Thr Leu Glu Leu Phe Lys Glu Tyr Gln Glu Glu 
            420                 425                 430         


Ala Tyr Ser Ile Ser Leu His Pro Ser Gly His Phe Ile Val Val Gly 
        435                 440                 445             


Phe Ala Asp Lys Leu Arg Leu Met Asn Leu Leu Ile Asp Asp Ile Arg 
    450                 455                 460                 


Ser Phe Lys Glu Tyr Ser Val Arg Gly Cys Gly Glu Cys Ser Phe Ser 
465                 470                 475                 480 


Asn Gly Gly His Leu Phe Ala Ala Val Asn Gly Asn Val Ile His Val 
                485                 490                 495     


Tyr Thr Thr Thr Ser Leu Glu Asn Ile Ser Ser Leu Lys Gly His Thr 
            500                 505                 510         


Gly Lys Met Leu Leu Thr Phe Asp Asp Gln Phe Leu Leu Thr Ala Ala 
        515                 520                 525             


Glu Asp Gly Cys Leu Phe Thr Trp Lys Val Phe Asp Lys Asp Gly Arg 
    530                 535                 540                 


Gly Ile Lys Arg Glu Arg Glu Val Gly Phe Ala Glu Glu Val Leu Val 
545                 550                 555                 560 


Thr Lys Thr Asp Met Glu Glu Lys Ala Gln Val Met Leu Glu Leu Lys 
                565                 570                 575     


Thr Arg Val Glu Glu Leu Lys Met Glu Asn Glu Tyr Gln Leu Arg Leu 
            580                 585                 590         


Lys Asp Met Asn Tyr Ser Glu Lys Ile Lys Glu Leu Thr Asp Lys Phe 
        595                 600                 605             


Ile Gln Glu Met Glu Ser Leu Lys Thr Lys Asn Gln Val Leu Arg Thr 
    610                 615                 620                 


Glu Lys Glu Lys Gln Asp Val Tyr His His Glu His Ile Glu Asp Leu 
625                 630                 635                 640 


Leu Asp Lys Gln Ser Arg Glu Leu Gln Asp Met Glu Cys Cys Asn Asn 
                645                 650                 655     


Gln Lys Leu Leu Leu Glu Tyr Glu Lys Tyr Gln Glu Leu Gln Leu Lys 
            660                 665                 670         


Ser Gln Arg Met Gln Glu Glu Tyr Glu Lys Gln Leu Arg Asp Asn Asp 
        675                 680                 685             


Glu Thr Lys Ser Gln Ala Leu Glu Glu Leu Thr Glu Phe Tyr Glu Ala 
    690                 695                 700                 


Lys Leu Gln Glu Lys Thr Thr Leu Leu Glu Glu Ala Gln Glu Asp Val 
705                 710                 715                 720 


Arg Gln Gln Leu Arg Glu Phe Glu Glu Thr Lys Lys Gln Ile Glu Glu 
                725                 730                 735     


Asp Glu Asp Arg Glu Ile Gln Asp Ile Lys Thr Lys Tyr Glu Lys Lys 
            740                 745                 750         


Leu Arg Asp Glu Lys Glu Ser Asn Leu Arg Leu Lys Gly Glu Thr Gly 
        755                 760                 765             


Ile Met Arg Lys Lys Phe Ser Ser Leu Gln Lys Glu Ile Glu Glu Arg 
    770                 775                 780                 


Thr Asn Asp Ile Glu Thr Leu Lys Gly Glu Gln Met Lys Leu Gln Gly 
785                 790                 795                 800 


Val Ile Lys Ser Leu Glu Lys Asp Ile Gln Gly Leu Lys Arg Glu Ile 
                805                 810                 815     


Gln Glu Arg Asp Glu Thr Ile Gln Asp Lys Glu Lys Arg Ile Tyr Asp 
            820                 825                 830         


Leu Lys Lys Lys Asn Gln Glu Leu Gly Lys Phe Lys Phe Val Leu Asp 
        835                 840                 845             


Tyr Lys Ile Lys Glu Leu Lys Lys Gln Ile Glu Pro Arg Glu Asn Glu 
    850                 855                 860                 


Ile Arg Val Met Lys Glu Gln Ile Gln Glu Met Glu Ala Glu Leu Glu 
865                 870                 875                 880 


Asn Phe His Lys Gln Asn Thr Gln Leu Glu Leu Asn Ile Thr Glu Leu 
                885                 890                 895     


Trp Gln Lys Leu Arg Ala Thr Asp Gln Glu Met Arg Arg Glu Arg Gln 
            900                 905                 910         


Lys Glu Arg Asp Leu Glu Ala Leu Val Lys Arg Phe Lys Thr Asp Leu 
        915                 920                 925             


His Asn Cys Val Ala Tyr Ile Gln Glu Pro Arg Leu Leu Lys Glu Lys 
    930                 935                 940                 


Val Arg Gly Leu Phe Glu Lys Tyr Val Gln Arg Ala Asp Met Val Glu 
945                 950                 955                 960 


Ile Ala Gly Leu Asn Thr Asp Leu Gln Gln Glu Tyr Thr Arg Gln Arg 
                965                 970                 975     


Glu His Leu Glu Arg Asn Leu Ala Thr Leu Lys Lys Lys Val Val Lys 
            980                 985                 990         


Glu Gly Glu Leu His Arg Thr Asp  Tyr Val Arg Ile Met  Gln Glu Asn 
        995                 1000                 1005             


Val Ser  Leu Ile Lys Glu Ile  Asn Glu Leu Arg Arg  Glu Leu Lys 
    1010                 1015                 1020             


Phe Thr  Arg Ser Gln Val Tyr  Asp Leu Glu Ala Ala  Leu Lys Leu 
    1025                 1030                 1035             


Thr Lys  Lys Val Arg Pro Gln  Glu Val Ser Glu Thr  Glu Pro Ser 
    1040                 1045                 1050             


Arg Asp  Met Leu Ser Thr Ala  Pro Thr Ala Arg Leu  Asn Glu Gln 
    1055                 1060                 1065             


Glu Glu  Thr Gly Arg Ile Ile  Glu Met Gln Arg Leu  Glu Ile Gln 
    1070                 1075                 1080             


Arg Leu  Arg Asp Gln Ile Gln  Glu Gln Glu Gln Val  Thr Gly Phe 
    1085                 1090                 1095             


His Thr  Leu Ala Gly Val Arg  Leu Pro Ser Leu Ser  Asn Ser Glu 
    1100                 1105                 1110             


Val Asp  Leu Glu Val Lys Thr  Asn 
    1115                 1120     


<210>  2069
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP58__Homo_sapiens__NP_001008723

<400>  2069

Met Ala Glu Glu Lys Gly Gly Lys Gln Val Leu Glu Glu Ser Ala Phe 
1               5                   10                  15      


Glu Glu Met Glu Arg Asp Phe Gln Gly Val Leu His Glu Leu Ser Gly 
            20                  25                  30          


Asp Lys Ser Leu Glu Lys Phe Arg Ile Glu Tyr Glu Arg Leu His Ala 
        35                  40                  45              


Val Met Lys Lys Ser Tyr Asp Asn Glu Lys Arg Leu Met Ala Lys Cys 
    50                  55                  60                  


Arg Glu Leu Asn Ala Glu Ile Val Val Asn Ser Ala Lys Val Ala Thr 
65                  70                  75                  80  


Ala Leu Lys Leu Ser Gln Asp Asp Gln Thr Thr Ile Ala Ser Leu Lys 
                85                  90                  95      


Lys Glu Ile Glu Lys Ala Trp Lys Met Val Asp Ser Ala Tyr Asp Lys 
            100                 105                 110         


Glu Gln Lys Ala Lys Glu Thr Ile Leu Ala Leu Lys Glu Glu Ile Val 
        115                 120                 125             


Asn Leu Thr Lys Leu Val Glu Gln Gly Ser Gly Leu Ser Met Asp Gln 
    130                 135                 140                 


His Ser Asn Ile Arg Asp Leu Leu Arg Phe Lys Glu Glu Val Thr Lys 
145                 150                 155                 160 


Glu Arg Asp Gln Leu Leu Ser Glu Val Val Lys Leu Arg Glu Ser Leu 
                165                 170                 175     


Ala Gln Thr Thr Glu Gln Gln Gln Glu Thr Glu Arg Ser Lys Glu Glu 
            180                 185                 190         


Ala Glu His Ala Ile Ser Gln Phe Gln Gln Glu Ile Gln Gln Arg Gln 
        195                 200                 205             


Asn Glu Ala Ser Arg Glu Phe Arg Lys Lys Glu Lys Leu Glu Lys Glu 
    210                 215                 220                 


Leu Lys Gln Ile Gln Ala Asp Met Asp Ser Arg Gln Thr Glu Ile Lys 
225                 230                 235                 240 


Ala Leu Gln Gln Tyr Val Gln Lys Ser Lys Glu Glu Leu Gln Lys Leu 
                245                 250                 255     


Glu Gln Gln Leu Lys Glu Gln Lys Ile Leu Asn Glu Arg Ala Ala Lys 
            260                 265                 270         


Glu Leu Glu Gln Phe Gln Met Arg Asn Ala Lys Leu Gln Gln Glu Asn 
        275                 280                 285             


Glu Gln His Ser Leu Val Cys Glu Gln Leu Ser Gln Glu Asn Gln Gln 
    290                 295                 300                 


Lys Ala Leu Glu Leu Lys Ala Lys Glu Glu Glu Val His Gln Met Arg 
305                 310                 315                 320 


Leu Asp Ile Gly Lys Leu Asn Lys Ile Arg Glu Gln Ile His Lys Lys 
                325                 330                 335     


Leu His His Thr Glu Asp Gln Lys Ala Glu Val Glu Gln His Lys Glu 
            340                 345                 350         


Thr Leu Lys Asn Gln Ile Val Gly Leu Glu Arg Glu Val Glu Ala Ser 
        355                 360                 365             


Lys Lys Gln Ala Glu Leu Asp Arg Lys Ala Met Asp Glu Leu Leu Arg 
    370                 375                 380                 


Glu Arg Asp Ile Leu Asn Lys Asn Met Leu Lys Ala Val Asn Ala Thr 
385                 390                 395                 400 


Gln Lys Gln Thr Asp Leu Val Lys Leu His Glu Gln Ala Lys Arg Asn 
                405                 410                 415     


Leu Glu Gly Glu Ile Gln Asn Tyr Lys Asp Glu Ala Gln Lys Gln Arg 
            420                 425                 430         


Lys Ile Ile Phe His Leu Glu Lys Glu Arg Asp Arg Tyr Ile Asn Gln 
        435                 440                 445             


Ala Ser Asp Leu Thr Gln Lys Val Leu Met Asn Met Glu Asp Ile Lys 
    450                 455                 460                 


Val Arg Glu Thr Gln Ile Phe Asp Tyr Arg Lys Lys Ile Ala Glu Ser 
465                 470                 475                 480 


Glu Ile Lys Leu Lys Gln Gln Gln Asn Leu Tyr Glu Ala Val Arg Ser 
                485                 490                 495     


Asp Arg Asn Leu Tyr Ser Lys Asn Leu Val Glu Ala Gln Asp Glu Ile 
            500                 505                 510         


Thr Asp Met Lys Arg Lys Leu Lys Ile Met Ile His Gln Val Asp Glu 
        515                 520                 525             


Leu Lys Glu Asp Ile Ser Ala Lys Glu Ser Ala Leu Val Lys Leu His 
    530                 535                 540                 


Leu Glu Gln Gln Arg Ile Glu Lys Glu Lys Glu Thr Leu Lys Ala Glu 
545                 550                 555                 560 


Leu Gln Lys Leu Arg Gln Gln Ala Leu Glu Thr Lys His Phe Ile Glu 
                565                 570                 575     


Lys Gln Glu Ala Glu Glu Arg Lys Leu Leu Arg Ile Ile Ala Glu Ala 
            580                 585                 590         


Asp Gly Glu Arg Leu Arg Gln Lys Lys Glu Leu Asp Gln Val Ile Ser 
        595                 600                 605             


Glu Arg Asp Ile Leu Gly Ser Gln Leu Val Arg Arg Asn Asp Glu Leu 
    610                 615                 620                 


Ala Leu Leu Tyr Glu Lys Ile Lys Ile Gln Gln Ser Val Leu Asn Lys 
625                 630                 635                 640 


Gly Glu Ser Gln Tyr Asn Gln Arg Leu Glu Asp Met Arg Ile Leu Arg 
                645                 650                 655     


Leu Glu Ile Lys Lys Leu Arg Arg Glu Lys Gly Ile Leu Ala Arg Ser 
            660                 665                 670         


Met Ala Asn Val Glu Glu Leu Arg Gln Glu Phe Phe His Met Gln Arg 
        675                 680                 685             


Glu Leu Leu Lys Glu Arg Thr Arg Cys Arg Ala Leu Glu Glu Glu Leu 
    690                 695                 700                 


Glu Asn Pro Leu Asn Val His Arg Trp Arg Lys Leu Glu Ala Ser Asp 
705                 710                 715                 720 


Pro Asn Ala Tyr Glu Leu Ile Gln Lys Ile His Thr Leu Gln Lys Arg 
                725                 730                 735     


Leu Ile Ser Lys Thr Glu Glu Val Val Glu Lys Glu Leu Leu Leu Gln 
            740                 745                 750         


Glu Lys Glu Lys Leu Tyr Met Glu Leu Lys His Val Leu Ala Arg Gln 
        755                 760                 765             


Pro Gly Pro Glu Ala Ala Glu Gln Leu Lys Leu Tyr Arg Arg Thr Leu 
    770                 775                 780                 


His Asp Lys Lys Gln Gln Leu Lys Val Leu Ser Ser Glu Leu Asn Met 
785                 790                 795                 800 


Tyr Glu Val Gln Ser Lys Glu Tyr Lys Tyr Glu Val Glu Lys Leu Thr 
                805                 810                 815     


Asn Glu Leu Gln Asn Leu Lys Lys Lys Tyr Leu Ala Gln Lys Arg Lys 
            820                 825                 830         


Glu Gln Leu Gln Lys Asn Lys Asp Thr Ala Pro Met Asp Asn Thr Phe 
        835                 840                 845             


Leu Met Val Lys Pro Asn Gly Pro Gly Phe Thr Gly Gly Gly Phe Pro 
    850                 855                 860                 


Leu Arg Ser Thr Lys Met Thr Phe 
865                 870         


<210>  2070
<211>  1237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP61__Homo_sapiens__NP_056400

<400>  2070

Met Ser Val Leu Thr Ser Pro Arg Gly Lys Val Glu Val Val His Cys 
1               5                   10                  15      


Arg Arg Thr Glu Ser Gln Asp Val Tyr Cys Ile Lys Ser Leu Ile Arg 
            20                  25                  30          


Lys Phe Thr Cys Lys Leu Phe Gly Lys Leu Asn Ile Ile Tyr Leu Leu 
        35                  40                  45              


Glu Lys Ala Asn Leu Ala Val Thr Leu Cys Asn Asp Lys Glu Glu Ile 
    50                  55                  60                  


Met Ala Gln Ala Thr Phe Leu Asp Tyr Pro Asn Trp Asn Val Ala Lys 
65                  70                  75                  80  


Gln Asp Asp Trp Val Ser Val Phe Arg Glu Leu Asp Ser Asp Ile Pro 
                85                  90                  95      


Cys Thr Pro Leu Asn Thr Leu Phe Met His Leu Phe Val Ala Val Asp 
            100                 105                 110         


Glu Tyr Ser Val Gly Cys Cys Lys Glu Ile Leu Arg Thr Val Tyr Lys 
        115                 120                 125             


Ala Val Pro Glu Leu His Phe Ile Phe Leu Ile Val Pro Ser Tyr Met 
    130                 135                 140                 


Ser Leu Gly Ser Thr Leu Ile Thr Val Phe Asp Gln Val Gly Asn Ile 
145                 150                 155                 160 


Pro Cys Leu Thr Tyr Glu Glu Asp Phe Ala Val His Ile Cys His Arg 
                165                 170                 175     


His Ser His Tyr Pro Gln Leu His Val Arg Lys Ala Arg Val Glu Asp 
            180                 185                 190         


His Asp Asp Leu Met Pro Ile Phe Met Arg Tyr Asp Thr Ile Leu Lys 
        195                 200                 205             


Glu Thr Tyr Gly Glu Tyr Phe Leu Ala Glu Leu Ile Glu Ala Gln Asp 
    210                 215                 220                 


Glu Glu Asn His Ala Val Val Cys Glu Val Glu Gly Thr Ala Val Gly 
225                 230                 235                 240 


Phe Met Ser Val Cys Ser Arg Val Asn Met Gln Leu Leu His Glu Cys 
                245                 250                 255     


Phe Asp Leu Gly Pro Phe His Gly Leu Cys Phe Pro His Pro Asp Asp 
            260                 265                 270         


Val Leu Glu Ser Pro Gln Asp Leu Ser Val Arg Arg Ser Gln Asp Ala 
        275                 280                 285             


Glu Leu Arg Ser Ser Ser Gln Gly Ser Gln Lys Ile Val Glu Glu Leu 
    290                 295                 300                 


Gln Glu Pro Val Ser Pro Asp Thr Met Glu Asn Ile Gln Gly Asn Ile 
305                 310                 315                 320 


Ala Arg Glu Ala Ala Ser Glu Glu Ala Leu Thr Ala Val Gln Ser Gly 
                325                 330                 335     


Asn Val Ser Glu Pro Glu Asp Ile Glu Lys Leu Ser Asp Ile Ser Thr 
            340                 345                 350         


Gly Tyr Ala Gln Tyr His His Val Ser Ser Arg Ser Leu Ala Ser Leu 
        355                 360                 365             


Val Leu Pro Glu Glu Pro Val His Phe Arg Pro Ile Tyr Arg Gly Ala 
    370                 375                 380                 


Ser Ala Ala Phe Cys Ile Gln Leu Phe Cys Ile Asp Glu Lys Tyr Glu 
385                 390                 395                 400 


Ala Arg Ser Leu Asp Phe Met Asn Phe Val Phe Ser Leu Phe Ser Asp 
                405                 410                 415     


Lys Asn Phe Cys Val Ile Ser Leu Pro His Leu Thr Pro Glu Phe Phe 
            420                 425                 430         


Leu Ile Gln Asn Phe Val Lys Met Val Pro Phe Asn Thr Cys Thr Leu 
        435                 440                 445             


Glu Gln Asp Leu Tyr Val Phe His Arg Ala Gly Leu Leu Lys Ser Ile 
    450                 455                 460                 


Asn Ile Arg Phe Ala Thr Leu Leu Asp Thr Pro Gly Val Glu Asn Leu 
465                 470                 475                 480 


Val Ser Thr Leu Met Leu Asn Lys Ser Ile Leu Glu Asp Leu Asp Arg 
                485                 490                 495     


Tyr Asn Lys Ala Arg Lys Asp Pro Asp Gly Thr Leu Leu Gln Ala Phe 
            500                 505                 510         


Val Ala Glu Val Ala Glu Gln Ile Val Gly Ile Ala Val Ile Arg Asn 
        515                 520                 525             


Glu Met Asp Ile Glu Tyr Ile Arg Ser His Tyr Asn Ile Glu Asp Phe 
    530                 535                 540                 


Ile Tyr Phe Ser His His Gln Arg Glu Glu His Gly His Met His His 
545                 550                 555                 560 


Phe Ala Leu Asn Pro Ile Phe Arg His Tyr Thr Lys Phe Phe Leu Lys 
                565                 570                 575     


Glu Ile Leu Arg Leu Gly Phe Lys Ser Cys Leu Tyr Tyr Arg Val Tyr 
            580                 585                 590         


Pro Lys Ser Arg Glu Gly Lys Phe Gln Asn Pro Tyr Ala His Ser Leu 
        595                 600                 605             


Thr Ser Ala Leu His Tyr Leu Val Pro Val Arg Pro Arg Arg Gln Ile 
    610                 615                 620                 


Val Tyr Pro Leu Glu Lys Leu Gly Ile Asn Ala Pro Ser Lys Ala Val 
625                 630                 635                 640 


Ser Lys Asp Pro Met Ser Tyr Ala Leu Asn His Thr Asn Arg Lys Leu 
                645                 650                 655     


Thr Leu Glu Pro Lys Ile Thr Val Asn Ala Lys Ile Ile Val Val Gly 
            660                 665                 670         


Ala Ser Ser Val Gly Ile Ser Phe Leu Glu Thr Leu Val Phe Cys Ser 
        675                 680                 685             


His Met Lys Phe Asn Asn Leu Thr Leu Ile Ser Thr His Gly Leu Pro 
    690                 695                 700                 


Gly Lys Lys Leu Leu Asp Thr Glu Gln Arg Lys Phe Leu Ala Ser Asp 
705                 710                 715                 720 


His Cys Phe Asn Asp Lys Asp Tyr Ala Leu Met Ser Leu Cys Ser Trp 
                725                 730                 735     


Val Asn Val Val Val Gly Arg Met Thr Gly Ile Asp Arg Ala Ala Lys 
            740                 745                 750         


His Val Val Leu Ser Thr Asp Glu Ile Val Pro Tyr Asp His Leu Ile 
        755                 760                 765             


Leu Cys Thr Gly Gln Gln Tyr Gln Val Pro Cys Pro Thr Glu Ala Asp 
    770                 775                 780                 


Ile Ser Gln His Leu Thr Asn Arg Glu Val Pro Asn Ser Ser Gln Arg 
785                 790                 795                 800 


Arg Tyr Thr Gly Lys Val Pro Cys Asn His Phe Thr Leu Asn Glu Glu 
                805                 810                 815     


Glu Asp Cys Phe Lys Ala Leu Ile Trp Ile Arg Asn Asn Ser Ile Thr 
            820                 825                 830         


Thr Glu Gly Asn Ile Ile Val Tyr Gly Asn Thr Ile Asp Thr Tyr Thr 
        835                 840                 845             


Thr Val Glu Thr Leu Leu Asn Leu Gly Val Ser Gly Ser Arg Ile His 
    850                 855                 860                 


Leu Val Gln Pro Pro Pro Ala Ser Thr Ile Thr Cys Ile Asn Asn Tyr 
865                 870                 875                 880 


Ser Val Glu Ser Ala Val Ala Asp Ala Leu Gly Ala Ala Gly Val Thr 
                885                 890                 895     


Met Tyr Arg Asp Ala Ile Leu Ala Gln Trp Asn Asp Gly Leu His Pro 
            900                 905                 910         


Asp Pro Ile Tyr Ser Ala Ser Phe Thr Thr Pro Thr Lys Pro Phe Arg 
        915                 920                 925             


Leu Gln Cys Ser Met Phe Phe Ser Phe Cys Glu Lys Asn Val Asp Tyr 
    930                 935                 940                 


Glu Thr Phe Lys Ala Leu Asn Asp Ala Cys Leu Val Tyr Asp Ser Arg 
945                 950                 955                 960 


Leu Val Ile Asp Thr Asn Phe His Thr Asn Asp Ile Ala Ile Arg Ala 
                965                 970                 975     


Ala Gly Ser Leu Thr Lys Phe Ser Asn Arg Tyr Tyr Ser Asn Glu Trp 
            980                 985                 990         


Thr His Ser Asn Phe Ser Ser Lys  Glu Ile Gly Phe Gln  Leu Ala Ala 
        995                 1000                 1005             


Ala Met  Leu His Leu Phe Asp  Pro Thr Leu Glu Pro  Val Thr Glu 
    1010                 1015                 1020             


Pro Pro  Ala Asn Leu Asp Arg  Leu Ile Pro Met Tyr  Lys Gly Ala 
    1025                 1030                 1035             


Lys Ile  Gln Gly Gly Ile Leu  Pro Gly Ser Tyr His  Tyr Leu His 
    1040                 1045                 1050             


Ile Ala  Lys Pro Ala Ile Pro  Thr Pro Leu Glu Val  Gln Met Ala 
    1055                 1060                 1065             


Gln Pro  Asn Tyr Gly Leu Glu  Leu Val Thr Gly Ser  Ala Lys Asn 
    1070                 1075                 1080             


Gly Thr  Tyr Phe Arg Ile His  Ile Asn Lys Tyr Lys  Met Val Glu 
    1085                 1090                 1095             


Thr Ile  Thr Cys Leu Ser Arg  Glu Pro Phe Pro Ala  Ser Asn Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Gly Gln His  Glu Gln Leu Leu Asn  Asn Leu Cys 
    1115                 1120                 1125             


Ala Arg  Tyr Asp Glu Asn Leu  Ile Thr Asp Leu Tyr  Ser Tyr Phe 
    1130                 1135                 1140             


Thr Glu  Pro Trp Cys Leu Ala  Leu Phe His Asp Arg  Phe Ile Asp 
    1145                 1150                 1155             


Leu Arg  Lys Glu Leu Arg Gln  Ile Leu Ala Ser Lys  Glu Glu Glu 
    1160                 1165                 1170             


Asp Leu  Pro Ser Ile Glu Gln  Leu Ala His Gln Ile  Glu Asp Glu 
    1175                 1180                 1185             


Glu Ile  Asn Pro Thr Glu Lys  Pro Arg Gln Tyr Leu  Lys Arg Val 
    1190                 1195                 1200             


Phe Glu  Glu Ser Ile Tyr Lys  Thr Leu Val Glu Arg  Ser Thr Leu 
    1205                 1210                 1215             


Asp Tyr  Leu His Tyr Asn Arg  Tyr His Leu Pro Met  Tyr Ala Trp 
    1220                 1225                 1230             


Pro Gly  Ile Val 
    1235         


<210>  2071
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP69__Homo_sapiens__NP_001034795

<400>  2071

Met Trp Thr Glu Glu Ala Gly Ala Thr Ala Glu Ala Gln Glu Ser Gly 
1               5                   10                  15      


Ile Arg Asn Lys Ser Ser Ser Ser Ser Gln Ile Pro Val Val Gly Val 
            20                  25                  30          


Val Thr Glu Asp Asp Glu Ala Gln Asp Val Phe Lys Pro Met Asp Leu 
        35                  40                  45              


Asn Arg Val Ile Lys Leu Leu Glu Glu Thr Asp Lys Asp Gly Leu Glu 
    50                  55                  60                  


Glu Lys Gln Leu Lys Phe Val Lys Lys Leu Val Gln Cys Tyr Gln Asn 
65                  70                  75                  80  


Gly Leu Pro Leu Arg Asp Leu Ala Gln Ile Phe Lys Ile Leu Asn Leu 
                85                  90                  95      


Cys Ser Gly Lys Ile Lys Asn Gln Pro Arg Phe Ile Glu Ser Ala Tyr 
            100                 105                 110         


Asp Ile Ile Lys Leu Cys Gly Leu Pro Phe Leu Lys Lys Lys Val Ser 
        115                 120                 125             


Asp Glu Ile Thr Tyr Ala Glu Asp Thr Ala Asn Ser Ile Ala Leu Leu 
    130                 135                 140                 


Gly Asp Leu Met Lys Ile Pro Ser Ser Glu Leu Arg Ile Gln Ile Cys 
145                 150                 155                 160 


Lys Cys Ile Val Asp Phe Tyr His Ala Glu Pro Pro Lys Lys His Ile 
                165                 170                 175     


Pro Gly Tyr Gln Gln Ala Ser Ser Ser Tyr Lys Ile Gln Met Ala Glu 
            180                 185                 190         


Val Gly Gly Leu Ala Lys Thr Met Val Gln Ser Met Thr Leu Leu Glu 
        195                 200                 205             


Asn Gln Leu Val Glu Lys Leu Trp Val Leu Lys Val Leu Gln His Leu 
    210                 215                 220                 


Ser Thr Ser Glu Val Asn Cys Thr Ile Met Met Lys Ala Gln Ala Ala 
225                 230                 235                 240 


Ser Gly Ile Cys Thr His Leu Asn Asp Pro Asp Pro Ser Gly Gln Leu 
                245                 250                 255     


Leu Phe Arg Ser Ser Glu Ile Leu Trp Asn Leu Leu Glu Lys Ser Ser 
            260                 265                 270         


Lys Glu Glu Val Ile Gln Gln Leu Ser Asn Leu Glu Cys Leu Leu Ala 
        275                 280                 285             


Leu Lys Glu Val Phe Lys Asn Leu Phe Met Arg Gly Phe Ser His Tyr 
    290                 295                 300                 


Asp Arg Gln Leu Arg Asn Asp Ile Leu Val Ile Thr Thr Ile Ile Ala 
305                 310                 315                 320 


Gln Asn Pro Glu Ala Pro Met Ile Glu Cys Gly Phe Thr Lys Asp Leu 
                325                 330                 335     


Ile Leu Phe Ala Thr Phe Asn Glu Val Lys Ser Gln Asn Leu Leu Val 
            340                 345                 350         


Lys Gly Leu Lys Leu Ser Asn Ser Tyr Glu Asp Phe Glu Leu Lys Lys 
        355                 360                 365             


Leu Leu Phe Asn Val Ile Val Ile Leu Cys Lys Asp Leu Pro Thr Val 
    370                 375                 380                 


Gln Leu Leu Ile Asp Gly Lys Val Ile Leu Ala Leu Phe Thr Tyr Val 
385                 390                 395                 400 


Lys Lys Pro Glu Lys Gln Lys Ile Ile Asp Trp Ser Ala Ala Gln His 
                405                 410                 415     


Glu Glu Leu Gln Leu His Ala Ile Ala Thr Leu Ser Ser Val Ala Pro 
            420                 425                 430         


Leu Leu Ile Glu Glu Tyr Met Ser Cys Gln Gly Asn Ala Arg Val Leu 
        435                 440                 445             


Ala Phe Leu Glu Trp Cys Glu Ser Glu Asp Pro Phe Phe Ser His Gly 
    450                 455                 460                 


Asn Ser Phe His Gly Thr Gly Gly Arg Gly Asn Lys Phe Ala Gln Met 
465                 470                 475                 480 


Arg Tyr Ser Leu Arg Leu Leu Arg Ala Val Val Tyr Leu Glu Asp Glu 
                485                 490                 495     


Thr Val Asn Lys Asp Leu Cys Glu Lys Gly Thr Ile Gln Gln Met Ile 
            500                 505                 510         


Gly Ile Phe Lys Asn Ile Ile Ser Lys Pro Asn Glu Lys Glu Glu Ala 
        515                 520                 525             


Ile Val Leu Glu Ile Gln Ser Asp Ile Leu Leu Ile Leu Ser Gly Leu 
    530                 535                 540                 


Cys Glu Asn His Ile Gln Arg Lys Glu Ile Phe Gly Thr Glu Gly Val 
545                 550                 555                 560 


Asp Ile Val Leu His Val Met Lys Thr Asp Pro Arg Lys Leu Gln Ser 
                565                 570                 575     


Gly Leu Gly Tyr Asn Val Leu Leu Phe Ser Thr Leu Asp Ser Ile Trp 
            580                 585                 590         


Cys Cys Ile Leu Gly Cys Tyr Pro Ser Glu Asp Tyr Phe Leu Glu Lys 
        595                 600                 605             


Glu Gly Ile Phe Leu Leu Leu Asp Leu Leu Ala Leu Asn Gln Lys Lys 
    610                 615                 620                 


Phe Cys Asn Leu Ile Leu Gly Ile Met Val Glu Phe Cys Asp Asn Pro 
625                 630                 635                 640 


Lys Thr Ala Ala His Val Asn Ala Trp Gln Gly Lys Lys Asp Gln Thr 
                645                 650                 655     


Ala Ala Ser Leu Leu Ile Lys Leu Trp Arg Lys Glu Glu Lys Glu Leu 
            660                 665                 670         


Gly Val Lys Arg Asp Lys Asn Gly Lys Ile Ile Asp Thr Lys Lys Pro 
        675                 680                 685             


Leu Phe Thr Ser Phe Gln Glu Glu Gln Lys Ile Ile Pro Leu Pro Ala 
    690                 695                 700                 


Asn Cys Pro Ser Ile Ala Val Met Asp Val Ser Glu Asn Ile Arg Ala 
705                 710                 715                 720 


Lys Ile Tyr Ala Ile Leu Gly Lys Leu Asp Phe Glu Asn Leu Pro Gly 
                725                 730                 735     


Leu Ser Ala Glu Asp Phe Val Thr Leu Cys Ile Ile His Arg Tyr Leu 
            740                 745                 750         


Asp Phe Lys Ile Gly Glu Ile Trp Asn Glu Ile Tyr Glu Glu Ile Lys 
        755                 760                 765             


Leu Glu Lys Leu Arg Pro Val Thr Thr Asp Lys Lys Ala Leu Glu Ala 
    770                 775                 780                 


Ile Thr Thr Ala Ser Glu Asn Ile Gly Lys Met Val Ala Ser Leu Gln 
785                 790                 795                 800 


Ser Asp Ile Ile Glu Ser Gln Ala Cys Gln Asp Met Gln Asn Glu Gln 
                805                 810                 815     


Lys Val Tyr Ala Lys Ile Gln Ala Thr His Lys Gln Arg Glu Leu Ala 
            820                 825                 830         


Asn Lys Ser Trp Glu Asp Phe Leu Ala Arg Thr Ser Asn Ala Lys Thr 
        835                 840                 845             


Leu Lys Lys Ala Lys Ser Leu Gln Glu Lys Ala Ile Glu Ala Ser Arg 
    850                 855                 860                 


Tyr His Lys Arg Pro Gln Asn Ala Ile Phe His Gln Thr His Ile Lys 
865                 870                 875                 880 


Gly Leu Asn Thr Thr Val Pro Ser Gly Gly Val Val Thr Val Glu Ser 
                885                 890                 895     


Thr Pro Ala Arg Leu Val Gly Gly Pro Leu Val Asp Thr Asp Ile Ala 
            900                 905                 910         


Leu Lys Lys Leu Pro Ile Arg Gly Gly Ala Leu Gln Arg Val Lys Ala 
        915                 920                 925             


Val Lys Ile Val Asp Ala Pro Lys Lys Ser Ile Pro Thr 
    930                 935                 940     


<210>  2072
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFAP97__Homo_sapiens__NP_001278962

<400>  2072

Met Asp Gln Phe Gly Asp Ile Leu Glu Gly Glu Val Asp His Ser Phe 
1               5                   10                  15      


Phe Asp Ser Asp Phe Glu Glu Gly Lys Lys Cys Glu Thr Asn Ser Val 
            20                  25                  30          


Phe Asp Lys Gln Asn Asp Asp Pro Lys Glu Arg Ile Asp Lys Asp Thr 
        35                  40                  45              


Lys Asn Val Asn Ser Asn Thr Gly Met Gln Thr Thr Glu Asn Tyr Leu 
    50                  55                  60                  


Thr Glu Lys Gly Asn Glu Arg Asn Val Lys Phe Pro Pro Glu His Pro 
65                  70                  75                  80  


Val Glu Asn Asp Val Thr Gln Thr Val Ser Ser Phe Ser Leu Pro Ala 
                85                  90                  95      


Ser Ser Arg Ser Lys Lys Leu Cys Asp Val Thr Thr Gly Leu Lys Ile 
            100                 105                 110         


His Val Ser Ile Pro Asn Arg Ile Pro Lys Ile Val Lys Glu Gly Glu 
        115                 120                 125             


Asp Asp Tyr Tyr Thr Asp Gly Glu Glu Ser Ser Asp Asp Gly Lys Lys 
    130                 135                 140                 


Tyr His Val Lys Ser Lys Ser Ala Lys Pro Ser Thr Asn Val Lys Lys 
145                 150                 155                 160 


Ser Ile Arg Lys Lys Tyr Cys Lys Val Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Leu Ser Ser Ser Ser Ser Gly Ser Gly Thr Asp Cys Leu Asp Ala Gly 
            180                 185                 190         


Ser Asp Ser His Leu Ser Asp Ser Ser Pro Ser Ser Lys Ser Ser Lys 
        195                 200                 205             


Lys His Val Ser Gly Ile Thr Leu Leu Ser Pro Lys His Lys Tyr Lys 
    210                 215                 220                 


Ser Gly Ile Lys Ser Thr Glu Thr Gln Pro Ser Ser Thr Thr Pro Lys 
225                 230                 235                 240 


Cys Gly His Tyr Pro Glu Glu Ser Glu Asp Thr Val Thr Asp Val Ser 
                245                 250                 255     


Pro Leu Ser Thr Pro Asp Ile Ser Pro Leu Gln Ser Phe Glu Leu Gly 
            260                 265                 270         


Ile Ala Asn Asp Gln Lys Val Lys Ile Lys Lys Gln Glu Asn Val Ser 
        275                 280                 285             


Gln Glu Ile Tyr Glu Asp Val Glu Asp Leu Lys Asn Asn Ser Lys Tyr 
    290                 295                 300                 


Leu Lys Ala Ala Lys Lys Gly Lys Glu Lys His Glu Pro Asp Val Ser 
305                 310                 315                 320 


Ser Lys Ser Ser Ser Val Leu Asp Ser Ser Leu Asp His Arg His Lys 
                325                 330                 335     


Gln Lys Val Leu His Asp Thr Met Asp Leu Asn His Leu Leu Lys Ala 
            340                 345                 350         


Phe Leu Gln Leu Asp Lys Lys Gly Pro Gln Lys His His Phe Asp Gln 
        355                 360                 365             


Pro Ser Val Ala Pro Gly Lys Asn Tyr Ser Phe Thr Arg Glu Glu Val 
    370                 375                 380                 


Arg Gln Ile Asp Arg Glu Asn Gln Arg Leu Leu Lys Glu Leu Ser Arg 
385                 390                 395                 400 


Gln Ala Glu Lys Pro Gly Ser Lys Ser Thr Ile Pro Arg Ser Ala Asp 
                405                 410                 415     


His Pro Pro Lys Leu Tyr His Ser Ala Leu Asn Arg Gln Lys Glu Gln 
            420                 425                 430         


Gln Arg Ile Glu Arg Glu Asn Leu Thr Ile Ser Leu Cys His Pro Gly 
        435                 440                 445             


Trp Ser Ala Val Thr 
    450             


<210>  2073
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFB__Homo_sapiens__NP_001701

<400>  2073

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


<210>  2074
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFC1B__Homo_sapiens__NP_001072998

<400>  2074

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Trp Ala Phe 
65                  70                  75                  80  


Gly Glu Gly Ala Ser Ala Arg Pro Arg Cys Cys Arg Asn Gly Gly Thr 
                85                  90                  95      


Cys Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg 
            100                 105                 110         


Tyr Cys Glu His Asp Gln Arg Arg Ser Glu Cys Gly Ala Leu Glu His 
        115                 120                 125             


Gly Ala Trp Thr Leu Arg Ala Cys His Leu Cys Arg Cys Ile Phe Gly 
    130                 135                 140                 


Ala Leu His Cys Leu Pro Leu Gln Thr Pro Asp Arg Cys Asp Pro Lys 
145                 150                 155                 160 


Asp Phe Leu Ala Ser His Ala His Gly Pro Ser Ala Gly Gly Ala Pro 
                165                 170                 175     


Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu His Arg Leu Leu Arg 
            180                 185                 190         


Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val Pro Ser Val Leu Gln 
        195                 200                 205             


Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu Gly His Arg Leu 
    210                 215                 220             


<210>  2075
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFC1__Homo_sapiens__NP_115934

<400>  2075

Met Thr Trp Arg His His Val Arg Leu Leu Phe Thr Val Ser Leu Ala 
1               5                   10                  15      


Leu Gln Ile Ile Asn Leu Gly Asn Ser Tyr Gln Arg Glu Lys His Asn 
            20                  25                  30          


Gly Gly Arg Glu Glu Val Thr Lys Val Ala Thr Gln Lys His Arg Gln 
        35                  40                  45              


Ser Pro Leu Asn Trp Thr Ser Ser His Phe Gly Glu Val Thr Gly Ser 
    50                  55                  60                  


Ala Glu Gly Trp Gly Pro Glu Glu Pro Leu Pro Tyr Ser Arg Ala Phe 
65                  70                  75                  80  


Gly Glu Gly Ala Ser Ala Arg Pro Arg Cys Cys Arg Asn Gly Gly Thr 
                85                  90                  95      


Cys Val Leu Gly Ser Phe Cys Val Cys Pro Ala His Phe Thr Gly Arg 
            100                 105                 110         


Tyr Cys Glu His Asp Gln Arg Arg Ser Glu Cys Gly Ala Leu Glu His 
        115                 120                 125             


Gly Ala Trp Thr Leu Arg Ala Cys His Leu Cys Arg Cys Ile Phe Gly 
    130                 135                 140                 


Ala Leu His Cys Leu Pro Leu Gln Thr Pro Asp Arg Cys Asp Pro Lys 
145                 150                 155                 160 


Asp Phe Leu Ala Ser His Ala His Gly Pro Ser Ala Gly Gly Ala Pro 
                165                 170                 175     


Ser Leu Leu Leu Leu Leu Pro Cys Ala Leu Leu His Arg Leu Leu Arg 
            180                 185                 190         


Pro Asp Ala Pro Ala His Pro Arg Ser Leu Val Pro Ser Val Leu Gln 
        195                 200                 205             


Arg Glu Arg Arg Pro Cys Gly Arg Pro Gly Leu Gly His Arg Leu 
    210                 215                 220             


<210>  2076
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFD__Homo_sapiens__NP_001919

<400>  2076

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250             


<210>  2077
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFDP1__Homo_sapiens__NP_006315

<400>  2077

Met Glu Glu Phe Asp Ser Glu Asp Phe Ser Thr Ser Glu Glu Asp Glu 
1               5                   10                  15      


Asp Tyr Val Pro Ser Gly Gly Glu Tyr Ser Glu Asp Asp Val Asn Glu 
            20                  25                  30          


Leu Val Lys Glu Asp Glu Val Asp Gly Glu Glu Gln Thr Gln Lys Thr 
        35                  40                  45              


Gln Gly Lys Lys Arg Lys Ala Gln Ser Ile Pro Ala Arg Lys Arg Arg 
    50                  55                  60                  


Gln Gly Gly Leu Ser Leu Glu Glu Glu Glu Glu Glu Asp Ala Asn Ser 
65                  70                  75                  80  


Glu Ser Glu Gly Ser Ser Ser Glu Glu Glu Asp Asp Ala Ala Glu Gln 
                85                  90                  95      


Glu Lys Gly Ile Gly Ser Glu Asp Ala Arg Lys Lys Lys Glu Asp Glu 
            100                 105                 110         


Leu Trp Ala Ser Phe Leu Asn Asp Val Gly Pro Lys Ser Lys Val Pro 
        115                 120                 125             


Pro Ser Thr Gln Val Lys Lys Gly Glu Glu Thr Glu Glu Thr Ser Ser 
    130                 135                 140                 


Ser Lys Leu Leu Val Lys Ala Glu Glu Leu Glu Lys Pro Lys Glu Thr 
145                 150                 155                 160 


Glu Lys Val Lys Ile Thr Lys Val Phe Asp Phe Ala Gly Glu Glu Val 
                165                 170                 175     


Arg Val Thr Lys Glu Val Asp Ala Thr Ser Lys Glu Ala Lys Ser Phe 
            180                 185                 190         


Phe Lys Gln Asn Glu Lys Glu Lys Pro Gln Ala Asn Val Pro Ser Ala 
        195                 200                 205             


Leu Pro Ser Leu Pro Ala Gly Ser Gly Leu Lys Arg Ser Ser Gly Met 
    210                 215                 220                 


Ser Ser Leu Leu Gly Lys Ile Gly Ala Lys Lys Gln Lys Met Ser Thr 
225                 230                 235                 240 


Leu Glu Lys Ser Lys Leu Asp Trp Glu Ser Phe Lys Glu Glu Glu Gly 
                245                 250                 255     


Ile Gly Glu Glu Leu Ala Ile His Asn Arg Gly Lys Glu Gly Tyr Ile 
            260                 265                 270         


Glu Arg Lys Ala Phe Leu Asp Arg Val Asp His Arg Gln Phe Glu Ile 
        275                 280                 285             


Glu Arg Asp Leu Arg Leu Ser Lys Met Lys Pro 
    290                 295                 


<210>  2078
<211>  1231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH__Homo_sapiens__NP_000177

<400>  2078

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  2079
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHR1__Homo_sapiens__NP_002104

<400>  2079

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  2080
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHR2__Homo_sapiens__NP_005657

<400>  2080

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
    130                 135                 140                 


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
        195                 200                 205             


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
    210                 215                 220                 


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
225                 230                 235                 240 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
                245                 250                 255     


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys 
            260                 265                 270 


<210>  2081
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHR3__Homo_sapiens__NP_001160096

<400>  2081

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys 
            180                 185                 190         


Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile 
        195                 200                 205             


Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg 
    210                 215                 220                 


Ser Asp Arg Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met 
225                 230                 235                 240 


Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala 
                245                 250                 255     


Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
            260                 265                 


<210>  2082
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHR4__Homo_sapiens__NP_001188480

<400>  2082

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly Gly 
            20                  25                  30          


Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala Gly 
        35                  40                  45              


Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu Asn 
                85                  90                  95      


Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu Thr 
            100                 105                 110         


Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser Ser 
        115                 120                 125             


Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile Cys 
    130                 135                 140                 


Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys Ser 
145                 150                 155                 160 


Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys Tyr 
                165                 170                 175     


Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val Cys 
            180                 185                 190         


Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser Glu 
        195                 200                 205             


Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu Phe 
            260                 265                 270         


Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg Pro 
        275                 280                 285             


Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln 
    290                 295                 300                 


Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr 
305                 310                 315                 320 


Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser Lys 
                325                 330                 335     


Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile 
            340                 345                 350         


Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala 
        355                 360                 365             


Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly 
    370                 375                 380                 


Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val Phe 
385                 390                 395                 400 


Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His Asp 
                405                 410                 415     


Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn 
            420                 425                 430         


Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe Pro 
        435                 440                 445             


Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser 
    450                 455                 460                 


Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser 
465                 470                 475                 480 


Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn 
                485                 490                 495     


Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile 
            500                 505                 510         


His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Gln 
        515                 520                 525             


Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr 
    530                 535                 540                 


Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu 
545                 550                 555                 560 


Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys 
                565                 570                 575     


Glu 
    


<210>  2083
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFHR5__Homo_sapiens__NP_110414

<400>  2083

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe 
            20                  25                  30          


Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys 
    130                 135                 140                 


Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro 
145                 150                 155                 160 


Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg 
                165                 170                 175     


Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe 
            180                 185                 190         


Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys 
        195                 200                 205             


Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys 
    210                 215                 220                 


Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn 
225                 230                 235                 240 


Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp 
                245                 250                 255     


Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile 
            260                 265                 270         


Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln 
        275                 280                 285             


His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile 
    290                 295                 300                 


Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro 
305                 310                 315                 320 


Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val 
                325                 330                 335     


Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn 
            340                 345                 350         


Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser 
        355                 360                 365             


Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys 
    370                 375                 380                 


Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn 
385                 390                 395                 400 


Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu 
                405                 410                 415     


Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys 
            420                 425                 430         


Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr 
        435                 440                 445             


Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser 
465                 470                 475                 480 


Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln 
                485                 490                 495     


Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu 
            500                 505                 510         


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys 
        515                 520                 525             


Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro 
    530                 535                 540                 


His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu 
545                 550                 555                 560 


Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
                565                 


<210>  2084
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFI__Homo_sapiens__NP_000195

<400>  2084

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Ala Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  2085
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFL1__Homo_sapiens__NP_005498

<400>  2085

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210>  2086
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFL2__Homo_sapiens__NP_068733

<400>  2086

Met Ala Ser Gly Val Thr Val Asn Asp Glu Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Gln Glu Glu Ile Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Asp Asp Lys Arg Gln Ile Ile 
        35                  40                  45              


Val Glu Glu Ala Lys Gln Ile Leu Val Gly Asp Ile Gly Asp Thr Val 
    50                  55                  60                  


Glu Asp Pro Tyr Thr Ser Phe Val Lys Leu Leu Pro Leu Asn Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe 
        115                 120                 125             


Thr Gly Ile Lys His Glu Trp Gln Val Asn Gly Leu Asp Asp Ile Lys 
    130                 135                 140                 


Asp Arg Ser Thr Leu Gly Glu Lys Leu Gly Gly Asn Val Val Val Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210>  2087
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFLAR__Homo_sapiens__NP_001120656

<400>  2087

Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Met Ile Thr Pro Tyr Ala 
        195                 200                 205             


His Cys Pro Asp Leu Lys Ile Leu Gly Asn Cys Ser Met 
    210                 215                 220     


<210>  2088
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFP__Homo_sapiens__NP_002612

<400>  2088

Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys 
            20                  25                  30          


Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly 
        35                  40                  45              


Gly Gly Val Ser Val Glu Asp Cys Cys Leu Asn Thr Ala Phe Ala Tyr 
    50                  55                  60                  


Gln Lys Arg Ser Gly Gly Leu Cys Gln Pro Cys Arg Ser Pro Arg Trp 
65                  70                  75                  80  


Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly 
                85                  90                  95      


Ser Gln Leu Arg Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser 
            100                 105                 110         


Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu 
        115                 120                 125             


Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro 
    130                 135                 140                 


Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg 
145                 150                 155                 160 


Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly 
                165                 170                 175     


Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr 
            180                 185                 190         


His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser 
        195                 200                 205             


Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys 
    210                 215                 220                 


Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly 
225                 230                 235                 240 


Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val 
                245                 250                 255     


Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr 
            260                 265                 270         


Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val 
        275                 280                 285             


Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His 
    290                 295                 300                 


Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser 
305                 310                 315                 320 


Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser 
                325                 330                 335     


Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly 
            340                 345                 350         


Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg 
        355                 360                 365             


His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu 
    370                 375                 380                 


Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr 
385                 390                 395                 400 


Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro 
                405                 410                 415     


Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp 
            420                 425                 430         


Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val 
        435                 440                 445             


Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro 
    450                 455                 460                 


Glu Glu Glu Glu Leu 
465                 


<210>  2089
<211>  1480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFTR__Homo_sapiens__NP_000483

<400>  2089

Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


<210>  2090
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGA__Homo_sapiens__NP_000726

<400>  2090

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210>  2091
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGB1__Homo_sapiens__NP_203695

<400>  2091

Met Ser Lys Arg Leu Leu Leu Leu Leu Leu Leu Ser Met Gly Gly Thr 
1               5                   10                  15      


Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala 
            20                  25                  30          


Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn 
        35                  40                  45              


Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val Leu Gln 
    50                  55                  60                  


Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg Asp Val 
65                  70                  75                  80  


Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asn Pro 
                85                  90                  95      


Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg 
            100                 105                 110         


Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys 
        115                 120                 125             


Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro 
    130                 135                 140                 


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
145                 150                 155 


<210>  2092
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGB2__Homo_sapiens__NP_203696

<400>  2092

Met Ser Lys Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly Gly Thr 
1               5                   10                  15      


Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala 
            20                  25                  30          


Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr Val Asn 
        35                  40                  45              


Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val Leu Gln 
    50                  55                  60                  


Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg Asp Val 
65                  70                  75                  80  


Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val Asn Pro 
                85                  90                  95      


Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg 
            100                 105                 110         


Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu Thr Cys 
        115                 120                 125             


Asp Asp Pro Arg Phe Gln Ala Ser Ser Ser Ser Lys Ala Pro Pro Pro 
    130                 135                 140                 


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile 
145                 150                 155                 160 


Leu Pro Gln 
            


<210>  2093
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGB5__Homo_sapiens__NP_149032

<400>  2093

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2094
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGB7__Homo_sapiens__XP_011525821

<400>  2094

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Arg Glu Met Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Ala Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  2095
<211>  1203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGN__Homo_sapiens__XP_005245422

<400>  2095

Met Glu Gln Ala Pro Asn Met Ala Glu Pro Arg Gly Pro Val Asp His 
1               5                   10                  15      


Gly Val Gln Ile Arg Phe Ile Thr Glu Pro Val Ser Gly Ala Glu Met 
            20                  25                  30          


Gly Thr Leu Arg Arg Gly Gly Arg Arg Pro Ala Lys Asp Ala Arg Ala 
        35                  40                  45              


Ser Thr Tyr Gly Val Ala Val Arg Val Gln Gly Ile Ala Gly Gln Pro 
    50                  55                  60                  


Phe Val Val Leu Asn Ser Gly Glu Lys Gly Gly Asp Ser Phe Gly Val 
65                  70                  75                  80  


Gln Ile Lys Gly Ala Asn Asp Gln Gly Ala Ser Gly Ala Leu Ser Ser 
                85                  90                  95      


Asp Leu Glu Leu Pro Glu Asn Pro Tyr Ser Gln Val Lys Gly Phe Pro 
            100                 105                 110         


Ala Pro Ser Gln Ser Ser Thr Ser Asp Glu Glu Pro Gly Ala Tyr Trp 
        115                 120                 125             


Asn Gly Lys Leu Leu Arg Ser His Ser Gln Ala Ser Leu Ala Gly Pro 
    130                 135                 140                 


Gly Pro Val Asp Pro Ser Asn Arg Ser Asn Ser Met Leu Glu Leu Ala 
145                 150                 155                 160 


Pro Lys Val Ala Ser Pro Gly Ser Thr Ile Asp Thr Ala Pro Leu Ser 
                165                 170                 175     


Ser Val Asp Ser Leu Ile Asn Lys Phe Asp Ser Gln Leu Gly Gly Gln 
            180                 185                 190         


Ala Arg Gly Arg Thr Gly Arg Arg Thr Arg Met Leu Pro Pro Glu Gln 
        195                 200                 205             


Arg Lys Arg Ser Lys Ser Leu Asp Ser Arg Leu Pro Arg Asp Thr Phe 
    210                 215                 220                 


Glu Glu Arg Glu Arg Gln Ser Thr Asn His Trp Thr Ser Ser Thr Lys 
225                 230                 235                 240 


Tyr Asp Asn His Val Gly Thr Ser Lys Gln Pro Ala Gln Ser Gln Asn 
                245                 250                 255     


Leu Ser Pro Leu Ser Gly Phe Ser Arg Ser Arg Gln Thr Gln Asp Trp 
            260                 265                 270         


Val Leu Gln Ser Phe Glu Glu Pro Arg Arg Ser Ala Gln Asp Pro Thr 
        275                 280                 285             


Met Leu Gln Phe Lys Ser Thr Pro Asp Leu Leu Arg Asp Gln Gln Glu 
    290                 295                 300                 


Ala Ala Pro Pro Gly Ser Val Asp His Met Lys Ala Thr Ile Tyr Gly 
305                 310                 315                 320 


Ile Leu Arg Glu Gly Ser Ser Glu Ser Glu Thr Ser Val Arg Arg Lys 
                325                 330                 335     


Val Ser Leu Val Leu Glu Lys Met Gln Pro Leu Val Met Val Ser Ser 
            340                 345                 350         


Gly Ser Thr Lys Ala Val Ala Gly Gln Gly Glu Leu Thr Arg Lys Val 
        355                 360                 365             


Glu Glu Leu Gln Arg Lys Leu Asp Glu Glu Val Lys Lys Arg Gln Lys 
    370                 375                 380                 


Leu Glu Pro Ser Gln Val Gly Leu Glu Arg Gln Leu Glu Glu Lys Thr 
385                 390                 395                 400 


Glu Glu Cys Ser Arg Leu Gln Glu Leu Leu Glu Arg Arg Lys Gly Glu 
                405                 410                 415     


Ala Gln Gln Ser Asn Lys Glu Leu Gln Asn Met Lys Arg Leu Leu Asp 
            420                 425                 430         


Gln Gly Glu Asp Leu Arg His Gly Leu Glu Thr Gln Val Met Glu Leu 
        435                 440                 445             


Gln Asn Lys Leu Lys His Val Gln Gly Pro Glu Pro Ala Lys Glu Val 
    450                 455                 460                 


Leu Leu Lys Asp Leu Leu Glu Thr Arg Glu Leu Leu Glu Glu Val Leu 
465                 470                 475                 480 


Glu Gly Lys Gln Arg Val Glu Glu Gln Leu Arg Leu Arg Glu Arg Glu 
                485                 490                 495     


Leu Thr Ala Leu Lys Gly Ala Leu Lys Glu Glu Val Ala Ser Arg Asp 
            500                 505                 510         


Gln Glu Val Glu His Val Arg Gln Gln Tyr Gln Arg Asp Thr Glu Gln 
        515                 520                 525             


Leu Arg Arg Ser Met Gln Asp Ala Thr Gln Asp His Ala Val Leu Glu 
    530                 535                 540                 


Ala Glu Arg Gln Lys Met Ser Ala Leu Val Arg Gly Leu Gln Arg Glu 
545                 550                 555                 560 


Leu Glu Glu Thr Ser Glu Glu Thr Gly His Trp Gln Ser Met Phe Gln 
                565                 570                 575     


Lys Asn Lys Glu Asp Leu Arg Ala Thr Lys Gln Glu Leu Leu Gln Leu 
            580                 585                 590         


Arg Met Glu Lys Glu Glu Met Glu Glu Glu Leu Gly Glu Lys Ile Glu 
        595                 600                 605             


Val Leu Gln Arg Glu Leu Glu Gln Ala Arg Ala Ser Ala Gly Asp Thr 
    610                 615                 620                 


Arg Gln Val Glu Val Leu Lys Lys Glu Leu Leu Arg Thr Gln Glu Glu 
625                 630                 635                 640 


Leu Lys Glu Leu Gln Ala Glu Arg Gln Ser Gln Glu Val Ala Gly Arg 
                645                 650                 655     


His Arg Asp Arg Glu Leu Glu Lys Gln Leu Ala Val Leu Arg Val Glu 
            660                 665                 670         


Ala Asp Arg Gly Arg Glu Leu Glu Glu Gln Asn Leu Gln Leu Gln Lys 
        675                 680                 685             


Thr Leu Gln Gln Leu Arg Gln Asp Cys Glu Glu Ala Ser Lys Ala Lys 
    690                 695                 700                 


Met Val Ala Glu Ala Glu Ala Thr Val Leu Gly Gln Arg Arg Ala Ala 
705                 710                 715                 720 


Val Glu Thr Thr Leu Arg Glu Thr Gln Glu Glu Asn Asp Glu Phe Arg 
                725                 730                 735     


Arg Arg Ile Leu Gly Leu Glu Gln Gln Leu Lys Glu Thr Arg Gly Leu 
            740                 745                 750         


Val Asp Gly Gly Glu Ala Val Glu Ala Arg Leu Arg Asp Lys Leu Gln 
        755                 760                 765             


Arg Leu Glu Ala Glu Lys Gln Gln Leu Glu Glu Ala Leu Asn Ala Ser 
    770                 775                 780                 


Gln Glu Glu Glu Gly Ser Leu Ala Ala Ala Lys Arg Ala Leu Glu Ala 
785                 790                 795                 800 


Arg Leu Glu Glu Ala Gln Arg Gly Leu Ala Arg Leu Gly Gln Glu Gln 
                805                 810                 815     


Gln Thr Leu Asn Arg Ala Leu Glu Glu Glu Gly Lys Gln Arg Glu Val 
            820                 825                 830         


Leu Arg Arg Gly Lys Ala Glu Leu Glu Glu Gln Lys Arg Leu Leu Asp 
        835                 840                 845             


Arg Thr Val Asp Arg Leu Asn Lys Glu Leu Glu Lys Ile Gly Glu Asp 
    850                 855                 860                 


Ser Lys Gln Ala Leu Gln Gln Leu Gln Ala Gln Leu Glu Asp Tyr Lys 
865                 870                 875                 880 


Glu Lys Ala Arg Arg Glu Val Ala Asp Ala Gln Arg Gln Ala Lys Asp 
                885                 890                 895     


Trp Ala Ser Glu Ala Glu Lys Thr Ser Gly Gly Leu Ser Arg Leu Gln 
            900                 905                 910         


Asp Glu Ile Gln Arg Leu Arg Gln Ala Leu Gln Ala Ser Gln Ala Glu 
        915                 920                 925             


Arg Asp Thr Ala Arg Leu Asp Lys Glu Leu Leu Ala Gln Arg Leu Gln 
    930                 935                 940                 


Gly Leu Glu Gln Glu Ala Glu Asn Lys Lys Arg Ser Gln Asp Asp Arg 
945                 950                 955                 960 


Ala Arg Gln Leu Lys Gly Leu Glu Glu Lys Val Ser Arg Leu Glu Thr 
                965                 970                 975     


Glu Leu Asp Glu Glu Lys Asn Thr Val Glu Leu Leu Thr Asp Arg Val 
            980                 985                 990         


Asn Arg Gly Arg Asp Gln Val Asp  Gln Leu Arg Thr Glu  Leu Met Gln 
        995                 1000                 1005             


Glu Arg  Ser Ala Arg Gln Asp  Leu Glu Cys Asp Lys  Ile Ser Leu 
    1010                 1015                 1020             


Glu Arg  Gln Asn Lys Asp Leu  Lys Thr Arg Leu Ala  Ser Ser Glu 
    1025                 1030                 1035             


Gly Phe  Gln Lys Pro Ser Ala  Ser Leu Ser Gln Leu  Glu Ser Gln 
    1040                 1045                 1050             


Asn Gln  Leu Leu Gln Glu Arg  Leu Gln Ala Glu Glu  Arg Glu Lys 
    1055                 1060                 1065             


Thr Val  Leu Gln Ser Thr Asn  Arg Lys Leu Glu Arg  Lys Val Lys 
    1070                 1075                 1080             


Glu Leu  Ser Ile Gln Ile Glu  Asp Glu Arg Gln His  Val Asn Asp 
    1085                 1090                 1095             


Gln Lys  Asp Gln Leu Ser Leu  Arg Val Lys Ala Leu  Lys Arg Gln 
    1100                 1105                 1110             


Val Asp  Glu Ala Glu Glu Glu  Ile Glu Arg Leu Asp  Gly Leu Arg 
    1115                 1120                 1125             


Lys Lys  Ala Gln Arg Glu Val  Glu Glu Gln His Glu  Val Asn Glu 
    1130                 1135                 1140             


Gln Leu  Gln Ala Arg Ile Lys  Ser Leu Glu Lys Asp  Ser Trp Arg 
    1145                 1150                 1155             


Lys Ala  Ser Arg Ser Ala Ala  Glu Ser Ala Leu Lys  Asn Glu Gly 
    1160                 1165                 1170             


Leu Ser  Ser Asp Glu Glu Phe  Asp Ser Val Tyr Asp  Pro Ser Ser 
    1175                 1180                 1185             


Ile Ala  Ser Leu Leu Thr Glu  Ser Asn Leu Gln Thr  Ser Ser Cys 
    1190                 1195                 1200             


<210>  2096
<211>  1302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGNL1__Homo_sapiens__NP_116255

<400>  2096

Met Glu Leu Tyr Phe Gly Glu Tyr Gln His Val Gln Gln Glu Tyr Gly 
1               5                   10                  15      


Val His Leu Arg Leu Ala Ser Asp Asp Thr Gln Lys Ser Arg Ser Ser 
            20                  25                  30          


Gln Asn Ser Lys Ala Gly Ser Tyr Gly Val Ser Ile Arg Val Gln Gly 
        35                  40                  45              


Ile Asp Gly His Pro Tyr Ile Val Leu Asn Asn Thr Glu Arg Cys Leu 
    50                  55                  60                  


Ala Gly Thr Ser Phe Ser Glu Asn Gly Pro Pro Phe Pro Pro Pro Val 
65                  70                  75                  80  


Ile Asn Asn Leu Pro Leu His Ser Ser Asn Gly Ser Val Pro Lys Glu 
                85                  90                  95      


Asn Ser Glu Glu Leu Gln Leu Pro Glu Asn Pro Tyr Ala Gln Pro Ser 
            100                 105                 110         


Pro Ile Arg Asn Leu Lys Gln Pro Leu Leu His Glu Gly Lys Asn Gly 
        115                 120                 125             


Val Leu Asp Arg Lys Asp Gly Ser Val Lys Pro Ser His Leu Leu Asn 
    130                 135                 140                 


Phe Gln Arg His Pro Glu Leu Leu Gln Pro Tyr Asp Pro Glu Lys Asn 
145                 150                 155                 160 


Glu Leu Asn Leu Gln Asn His Gln Pro Ser Glu Ser Asn Trp Leu Lys 
                165                 170                 175     


Thr Leu Thr Glu Glu Gly Ile Asn Asn Lys Lys Pro Trp Thr Cys Phe 
            180                 185                 190         


Pro Lys Pro Ser Asn Ser Gln Pro Thr Ser Pro Ser Leu Glu Asp Pro 
        195                 200                 205             


Ala Lys Ser Gly Val Thr Ala Ile Arg Leu Cys Ser Ser Val Val Ile 
    210                 215                 220                 


Glu Asp Pro Lys Lys Gln Thr Ser Val Cys Val Asn Val Gln Ser Cys 
225                 230                 235                 240 


Thr Lys Glu Arg Val Gly Glu Glu Ala Leu Phe Thr Ser Gly Arg Pro 
                245                 250                 255     


Leu Thr Ala His Ser Pro His Ala His Pro Glu Thr Lys Lys Thr Arg 
            260                 265                 270         


Pro Asp Val Leu Pro Phe Arg Arg Gln Asp Ser Ala Gly Pro Val Leu 
        275                 280                 285             


Asp Gly Ala Arg Ser Arg Arg Ser Ser Ser Ser Ser Thr Thr Pro Thr 
    290                 295                 300                 


Ser Ala Asn Ser Leu Tyr Arg Phe Leu Leu Asp Asp Gln Glu Cys Ala 
305                 310                 315                 320 


Ile His Ala Asp Asn Val Asn Arg His Glu Asn Arg Arg Tyr Ile Pro 
                325                 330                 335     


Phe Leu Pro Gly Thr Gly Arg Asp Ile Asp Thr Gly Ser Ile Pro Gly 
            340                 345                 350         


Val Asp Gln Leu Ile Glu Lys Phe Asp Gln Lys Pro Gly Leu Gln Arg 
        355                 360                 365             


Arg Gly Arg Ser Gly Lys Arg Asn Arg Ile Asn Thr Asp Asp Arg Lys 
    370                 375                 380                 


Arg Ser Arg Ser Val Asp Ser Ala Phe Pro Phe Gly Leu Gln Gly Asn 
385                 390                 395                 400 


Ser Glu Tyr Leu Ile Glu Phe Ser Arg Asn Leu Gly Lys Ser Ser Glu 
                405                 410                 415     


His Leu Leu Arg Pro Ser Gln Val Cys Pro Gln Arg Pro Leu Ser Gln 
            420                 425                 430         


Glu Arg Arg Gly Lys Gln Ser Val Gly Arg Thr Phe Ala Lys Leu Gln 
        435                 440                 445             


Gly Ala Ala His Gly Ala Ser Cys Ala His Ser Arg Pro Pro Gln Pro 
    450                 455                 460                 


Asn Ile Asp Gly Lys Val Leu Glu Thr Glu Gly Ser Gln Glu Ser Thr 
465                 470                 475                 480 


Val Ile Arg Ala Pro Ser Leu Gly Ala Gln Ser Lys Lys Glu Glu Glu 
                485                 490                 495     


Val Lys Thr Ala Thr Ala Thr Leu Met Leu Gln Asn Arg Ala Thr Ala 
            500                 505                 510         


Thr Ser Pro Asp Ser Gly Ala Lys Lys Ile Ser Val Lys Thr Phe Pro 
        515                 520                 525             


Ser Ala Ser Asn Thr Gln Ala Thr Pro Asp Leu Leu Lys Gly Gln Gln 
    530                 535                 540                 


Glu Leu Thr Gln Gln Thr Asn Glu Glu Thr Ala Lys Gln Ile Leu Tyr 
545                 550                 555                 560 


Asn Tyr Leu Lys Glu Gly Ser Thr Asp Asn Asp Asp Ala Thr Lys Arg 
                565                 570                 575     


Lys Val Asn Leu Val Phe Glu Lys Ile Gln Thr Leu Lys Ser Arg Ala 
            580                 585                 590         


Ala Gly Ser Ala Gln Gly Asn Asn Gln Ala Cys Asn Ser Thr Ser Glu 
        595                 600                 605             


Val Lys Asp Leu Leu Glu Gln Lys Ser Lys Leu Thr Ile Glu Val Ala 
    610                 615                 620                 


Glu Leu Gln Arg Gln Leu Gln Leu Glu Val Lys Asn Gln Gln Asn Ile 
625                 630                 635                 640 


Lys Glu Glu Arg Glu Arg Met Arg Ala Asn Leu Glu Glu Leu Arg Ser 
                645                 650                 655     


Gln His Asn Glu Lys Val Glu Glu Asn Ser Thr Leu Gln Gln Arg Leu 
            660                 665                 670         


Glu Glu Ser Glu Gly Glu Leu Arg Lys Asn Leu Glu Glu Leu Phe Gln 
        675                 680                 685             


Val Lys Met Glu Arg Glu Gln His Gln Thr Glu Ile Arg Asp Leu Gln 
    690                 695                 700                 


Asp Gln Leu Ser Glu Met His Asp Glu Leu Asp Ser Ala Lys Arg Ser 
705                 710                 715                 720 


Glu Asp Arg Glu Lys Gly Ala Leu Ile Glu Glu Leu Leu Gln Ala Lys 
                725                 730                 735     


Gln Asp Leu Gln Asp Leu Leu Ile Ala Lys Glu Glu Gln Glu Asp Leu 
            740                 745                 750         


Leu Arg Lys Arg Glu Arg Glu Leu Thr Ala Leu Lys Gly Ala Leu Lys 
        755                 760                 765             


Glu Glu Val Ser Ser His Asp Gln Glu Met Asp Lys Leu Lys Glu Gln 
    770                 775                 780                 


Tyr Asp Ala Glu Leu Gln Ala Leu Arg Glu Ser Val Glu Glu Ala Thr 
785                 790                 795                 800 


Lys Asn Val Glu Val Leu Ala Ser Arg Ser Asn Thr Ser Glu Gln Asp 
                805                 810                 815     


Gln Ala Gly Thr Glu Met Arg Val Lys Leu Leu Gln Glu Glu Asn Glu 
            820                 825                 830         


Lys Leu Gln Gly Arg Ser Glu Glu Leu Glu Arg Arg Val Ala Gln Leu 
        835                 840                 845             


Gln Arg Gln Ile Glu Asp Leu Lys Gly Asp Glu Ala Lys Ala Lys Glu 
    850                 855                 860                 


Thr Leu Lys Lys Tyr Glu Gly Glu Ile Arg Gln Leu Glu Glu Ala Leu 
865                 870                 875                 880 


Val His Ala Arg Lys Glu Glu Lys Glu Ala Val Ser Ala Arg Arg Ala 
                885                 890                 895     


Leu Glu Asn Glu Leu Glu Ala Ala Gln Gly Asn Leu Ser Gln Thr Thr 
            900                 905                 910         


Gln Glu Gln Lys Gln Leu Ser Glu Lys Leu Lys Glu Glu Ser Glu Gln 
        915                 920                 925             


Lys Glu Gln Leu Arg Arg Leu Lys Asn Glu Met Glu Asn Glu Arg Trp 
    930                 935                 940                 


His Leu Gly Lys Thr Ile Glu Lys Leu Gln Lys Glu Met Ala Asp Ile 
945                 950                 955                 960 


Val Glu Ala Ser Arg Thr Ser Thr Leu Glu Leu Gln Asn Gln Leu Asp 
                965                 970                 975     


Glu Tyr Lys Glu Lys Asn Arg Arg Glu Leu Ala Glu Met Gln Arg Gln 
            980                 985                 990         


Leu Lys Glu Lys Thr Leu Glu Ala  Glu Lys Ser Arg Leu  Thr Ala Met 
        995                 1000                 1005             


Lys Met  Gln Asp Glu Met Arg  Leu Met Glu Glu Glu  Leu Arg Asp 
    1010                 1015                 1020             


Tyr Gln  Arg Ala Gln Asp Glu  Ala Leu Thr Lys Arg  Gln Leu Leu 
    1025                 1030                 1035             


Glu Gln  Thr Leu Lys Asp Leu  Glu Tyr Glu Leu Glu  Ala Lys Ser 
    1040                 1045                 1050             


His Leu  Lys Asp Asp Arg Ser  Arg Leu Val Lys Gln  Met Glu Asp 
    1055                 1060                 1065             


Lys Val  Ser Gln Leu Glu Met  Glu Leu Glu Glu Glu  Arg Asn Asn 
    1070                 1075                 1080             


Ser Asp  Leu Leu Ser Glu Arg  Ile Ser Arg Ser Arg  Glu Gln Met 
    1085                 1090                 1095             


Glu Gln  Leu Arg Asn Glu Leu  Leu Gln Glu Arg Ala  Ala Arg Gln 
    1100                 1105                 1110             


Asp Leu  Glu Cys Asp Lys Ile  Ser Leu Glu Arg Gln  Asn Lys Asp 
    1115                 1120                 1125             


Leu Lys  Ser Arg Ile Ile His  Leu Glu Gly Ser Tyr  Arg Ser Ser 
    1130                 1135                 1140             


Lys Glu  Gly Leu Val Val Gln  Met Glu Ala Arg Ile  Ala Glu Leu 
    1145                 1150                 1155             


Glu Asp  Arg Leu Glu Ser Glu  Glu Arg Asp Arg Ala  Asn Leu Gln 
    1160                 1165                 1170             


Leu Ser  Asn Arg Arg Leu Glu  Arg Lys Val Lys Glu  Leu Val Met 
    1175                 1180                 1185             


Gln Val  Asp Asp Glu His Leu  Ser Leu Thr Asp Gln  Lys Asp Gln 
    1190                 1195                 1200             


Leu Ser  Leu Arg Leu Lys Ala  Met Lys Arg Gln Val  Glu Glu Ala 
    1205                 1210                 1215             


Glu Glu  Glu Ile Asp Arg Leu  Glu Ser Ser Lys Lys  Lys Leu Gln 
    1220                 1225                 1230             


Arg Glu  Leu Glu Glu Gln Met  Asp Met Asn Glu His  Leu Gln Gly 
    1235                 1240                 1245             


Gln Leu  Asn Ser Met Lys Lys  Asp Leu Arg Leu Lys  Lys Leu Pro 
    1250                 1255                 1260             


Ser Lys  Val Leu Asp Asp Met  Asp Asp Asp Asp Asp  Leu Ser Thr 
    1265                 1270                 1275             


Asp Gly  Gly Ser Leu Tyr Glu  Ala Pro Val Ser Tyr  Thr Phe Ser 
    1280                 1285                 1290             


Lys Asp  Ser Thr Val Ala Ser  Gln Ile 
    1295                 1300         


<210>  2097
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGRRF1__Homo_sapiens__NP_006559

<400>  2097

Met Ala Ala Val Phe Leu Val Thr Leu Tyr Glu Tyr Ser Pro Leu Phe 
1               5                   10                  15      


Tyr Ile Ala Val Val Phe Thr Cys Phe Ile Val Thr Thr Gly Leu Val 
            20                  25                  30          


Leu Gly Trp Phe Gly Trp Asp Val Pro Val Ile Leu Arg Asn Ser Glu 
        35                  40                  45              


Glu Thr Gln Phe Ser Thr Arg Val Phe Lys Lys Gln Met Arg Gln Val 
    50                  55                  60                  


Lys Asn Pro Phe Gly Leu Glu Ile Thr Asn Pro Ser Ser Ala Ser Ile 
65                  70                  75                  80  


Thr Thr Gly Ile Thr Leu Thr Thr Asp Cys Leu Glu Asp Ser Leu Leu 
                85                  90                  95      


Thr Cys Tyr Trp Gly Cys Ser Val Gln Lys Leu Tyr Glu Ala Leu Gln 
            100                 105                 110         


Lys His Val Tyr Cys Phe Arg Ile Ser Thr Pro Gln Ala Leu Glu Asp 
        115                 120                 125             


Ala Leu Tyr Ser Glu Tyr Leu Tyr Gln Glu Gln Tyr Phe Ile Lys Lys 
    130                 135                 140                 


Asp Ser Lys Glu Glu Ile Tyr Cys Gln Leu Pro Arg Asp Thr Lys Ile 
145                 150                 155                 160 


Glu Asp Phe Gly Thr Val Pro Arg Ser Arg Tyr Pro Leu Val Ala Leu 
                165                 170                 175     


Leu Thr Leu Ala Asp Glu Asp Asp Arg Glu Ile Tyr Asp Ile Ile Ser 
            180                 185                 190         


Met Val Ser Val Ile His Ile Pro Asp Arg Thr Tyr Lys Leu Ser Cys 
        195                 200                 205             


Arg Ile Leu Tyr Gln Tyr Leu Leu Leu Ala Gln Gly Gln Phe His Asp 
    210                 215                 220                 


Leu Lys Gln Leu Phe Met Ser Ala Asn Asn Asn Phe Thr Pro Ser Asn 
225                 230                 235                 240 


Asn Ser Ser Ser Glu Glu Lys Asn Thr Asp Arg Ser Leu Leu Glu Lys 
                245                 250                 255     


Val Gly Leu Ser Glu Ser Glu Val Glu Pro Ser Glu Glu Asn Ser Lys 
            260                 265                 270         


Asp Cys Val Val Cys Gln Asn Gly Thr Val Asn Trp Val Leu Leu Pro 
        275                 280                 285             


Cys Arg His Thr Cys Leu Cys Asp Gly Cys Val Lys Tyr Phe Gln Gln 
    290                 295                 300                 


Cys Pro Met Cys Arg Gln Phe Val Gln Glu Ser Phe Ala Leu Cys Ser 
305                 310                 315                 320 


Gln Lys Glu Gln Asp Lys Asp Lys Pro Lys Thr Leu 
                325                 330         


<210>  2098
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH25H__Homo_sapiens__NP_003947

<400>  2098

Met Ser Cys His Asn Cys Ser Asp Pro Gln Val Leu Cys Ser Ser Gly 
1               5                   10                  15      


Gln Leu Phe Leu Gln Pro Leu Trp Asp His Leu Arg Ser Trp Glu Ala 
            20                  25                  30          


Leu Leu Gln Ser Pro Phe Phe Pro Val Ile Phe Ser Ile Thr Thr Tyr 
        35                  40                  45              


Val Gly Phe Cys Leu Pro Phe Val Val Leu Asp Ile Leu Cys Ser Trp 
    50                  55                  60                  


Val Pro Ala Leu Arg Arg Tyr Lys Ile His Pro Asp Phe Ser Pro Ser 
65                  70                  75                  80  


Ala Gln Gln Leu Leu Pro Cys Leu Gly Gln Thr Leu Tyr Gln His Val 
                85                  90                  95      


Met Phe Val Phe Pro Val Thr Leu Leu His Trp Ala Arg Ser Pro Ala 
            100                 105                 110         


Leu Leu Pro His Glu Ala Pro Glu Leu Leu Leu Leu Leu His His Ile 
        115                 120                 125             


Leu Phe Cys Leu Leu Leu Phe Asp Met Glu Phe Phe Val Trp His Leu 
    130                 135                 140                 


Leu His His Lys Val Pro Trp Leu Tyr Arg Thr Phe His Lys Val His 
145                 150                 155                 160 


His Gln Asn Ser Ser Ser Phe Ala Leu Ala Thr Gln Tyr Met Ser Val 
                165                 170                 175     


Trp Glu Leu Phe Ser Leu Gly Phe Phe Asp Met Met Asn Val Thr Leu 
            180                 185                 190         


Leu Gly Cys His Pro Leu Thr Thr Leu Thr Phe His Val Val Asn Ile 
        195                 200                 205             


Trp Leu Ser Val Glu Asp His Ser Gly Tyr Asn Phe Pro Trp Ser Thr 
    210                 215                 220                 


His Arg Leu Val Pro Phe Gly Trp Tyr Gly Gly Val Val His His Asp 
225                 230                 235                 240 


Leu His His Ser His Phe Asn Cys Asn Phe Ala Pro Tyr Phe Thr His 
                245                 250                 255     


Trp Asp Lys Ile Leu Gly Thr Leu Arg Thr Ala Ser Val Pro Ala Arg 
            260                 265                 270         


<210>  2099
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAC1__Homo_sapiens__NP_001136248

<400>  2099

Met Gly Gly Ala Gln Leu Glu Leu Pro Ser Gly Ala Arg Pro Gly Val 
1               5                   10                  15      


Cys Val Arg Arg Ser Phe Arg Ala His Ala Gly Asp Gln Pro Arg Arg 
            20                  25                  30          


Pro Pro Gly Pro Ile Pro Val Pro Gly Thr Met Lys Gln Glu Ser Ala 
        35                  40                  45              


Ala Pro Asn Thr Pro Pro Thr Ser Gln Ser Pro Thr Pro Ser Ala Gln 
    50                  55                  60                  


Phe Pro Arg Asn Asp Gly Asp Pro Gln Ala Leu Trp Ile Phe Gly Tyr 
65                  70                  75                  80  


Gly Ser Leu Val Trp Arg Pro Asp Phe Ala Tyr Ser Asp Ser Arg Val 
                85                  90                  95      


Gly Phe Val Arg Gly Tyr Ser Arg Arg Phe Trp Gln Gly Asp Thr Phe 
            100                 105                 110         


His Arg Gly Ser Asp Lys Met Pro Gly Arg Val Val Thr Leu Leu Glu 
        115                 120                 125             


Asp His Glu Gly Cys Thr Trp Gly Val Ala Tyr Gln Val Gln Gly Glu 
    130                 135                 140                 


Gln Asn Pro Gly Tyr Leu Gly Pro Ala Pro Glu Glu Ala Ile Ala Thr 
145                 150                 155                 160 


Gln Ile Leu Ala Cys Arg Gly Phe Ser Gly His Asn Leu Glu Tyr Leu 
                165                 170                 175     


Leu Arg Leu Ala Asp Phe Met Gln Leu Cys Gly Pro Gln Ala Gln Asp 
            180                 185                 190         


Glu His Leu Ala Ala Ile Val Asp Ala Val Gly Thr Met Leu Pro Cys 
        195                 200                 205             


Phe Cys Pro Thr Glu Gln Ala Leu Ala Leu Val 
    210                 215                 


<210>  2100
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAD__Homo_sapiens__XP_011522516

<400>  2100

Met His Gly Ser Arg Leu Gly Glu Arg Pro Arg Pro Leu Pro Arg Gly 
1               5                   10                  15      


Gly Arg Gly Arg Ile Ser Gly Arg Glu Arg Val Lys Pro Ser Gly Leu 
            20                  25                  30          


Asp Ala Pro Arg Arg Ser Trp Leu Gly Cys Arg Leu Arg Ser Gly Pro 
        35                  40                  45              


Pro Tyr Lys Glu Gly Gly Arg Pro Glu Arg Leu Gly Leu Ala Ala Ala 
    50                  55                  60                  


Arg Ala Pro Pro Pro Leu Leu Pro Pro Ala Pro Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Met Val Arg Pro Met Leu Leu Leu Ser Leu Gly Leu Leu Ala Gly 
                85                  90                  95      


Leu Leu Pro Ala Leu Ala Ala Cys Pro Gln Asn Cys His Cys His Ser 
            100                 105                 110         


Asp Leu Gln His Val Ile Cys Asp Lys Val Gly Leu Gln Lys Ile Pro 
        115                 120                 125             


Lys Val Ser Glu Lys Thr Lys Leu Leu Asn Leu Gln Arg Asn Asn Phe 
    130                 135                 140                 


Pro Val Leu Ala Ala Asn Ser Phe Arg Ala Met Pro Asn Leu Val Ser 
145                 150                 155                 160 


Leu His Leu Gln His Cys Gln Ile Arg Glu Val Ala Ala Gly Ala Phe 
                165                 170                 175     


Arg Gly Leu Lys Gln Leu Ile Tyr Leu Tyr Leu Ser His Asn Asp Ile 
            180                 185                 190         


Arg Val Leu Arg Ala Gly Ala Phe Asp Asp Leu Thr Glu Leu Thr Tyr 
        195                 200                 205             


Leu Tyr Leu Asp His Asn Lys Val Thr Glu Leu Pro Arg Gly Leu Leu 
    210                 215                 220                 


Ser Pro Leu Val Asn Leu Phe Ile Leu Gln Leu Asn Asn Asn Lys Ile 
225                 230                 235                 240 


Arg Glu Leu Arg Ala Gly Ala Phe Gln Gly Ala Lys Asp Leu Arg Trp 
                245                 250                 255     


Leu Tyr Leu Ser Glu Asn Ala Leu Ser Ser Leu Gln Pro Gly Ala Leu 
            260                 265                 270         


Asp Asp Val Glu Asn Leu Ala Lys Phe His Val Asp Arg Asn Gln Leu 
        275                 280                 285             


Ser Ser Tyr Pro Ser Ala Ala Leu Ser Lys Leu Arg Val Val Glu Glu 
    290                 295                 300                 


Leu Lys Leu Ser His Asn Pro Leu Lys Ser Ile Pro Asp Asn Ala Phe 
305                 310                 315                 320 


Gln Ser Phe Gly Arg Tyr Leu Glu Thr Leu Trp Leu Asp Asn Thr Asn 
                325                 330                 335     


Leu Glu Lys Phe Ser Asp Gly Ala Phe Leu Gly Val Thr Thr Leu Lys 
            340                 345                 350         


His Val His Leu Glu Asn Asn Arg Leu Asn Gln Leu Pro Ser Asn Phe 
        355                 360                 365             


Pro Phe Asp Ser Leu Glu Thr Leu Ala Leu Thr Asn Asn Pro Trp Lys 
    370                 375                 380                 


Cys Thr Cys Gln Leu Arg Gly Leu Arg Arg Trp Leu Glu Ala Lys Ala 
385                 390                 395                 400 


Ser Arg Pro Asp Ala Thr Cys Ala Ser Pro Ala Lys Phe Lys Gly Gln 
                405                 410                 415     


His Ile Arg Asp Thr Asp Ala Phe Arg Ser Cys Lys Phe Pro Thr Lys 
            420                 425                 430         


Arg Ser Lys Lys Ala Gly Arg His 
        435                 440 


<210>  2101
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAF1A__Homo_sapiens__NP_005474

<400>  2101

Met Leu Glu Glu Leu Glu Cys Gly Ala Pro Gly Ala Arg Gly Ala Ala 
1               5                   10                  15      


Thr Ala Met Asp Cys Lys Asp Arg Pro Ala Phe Pro Val Lys Lys Leu 
            20                  25                  30          


Ile Gln Ala Arg Leu Pro Phe Lys Arg Leu Asn Leu Val Pro Lys Gly 
        35                  40                  45              


Lys Ala Asp Asp Met Ser Asp Asp Gln Gly Thr Ser Val Gln Ser Lys 
    50                  55                  60                  


Ser Pro Asp Leu Glu Ala Ser Leu Asp Thr Leu Glu Asn Asn Cys His 
65                  70                  75                  80  


Val Gly Ser Asp Ile Asp Phe Arg Pro Lys Leu Val Asn Gly Lys Gly 
                85                  90                  95      


Pro Leu Asp Asn Phe Leu Arg Asn Arg Ile Glu Thr Ser Ile Gly Gln 
            100                 105                 110         


Ser Thr Val Ile Ile Asp Leu Thr Glu Asp Ser Asn Glu Gln Pro Asp 
        115                 120                 125             


Ser Leu Val Asp His Asn Lys Leu Asn Ser Glu Ala Ser Pro Ser Arg 
    130                 135                 140                 


Glu Ala Ile Asn Gly Gln Arg Glu Asp Thr Gly Asp Gln Gln Gly Leu 
145                 150                 155                 160 


Leu Lys Ala Ile Gln Asn Asp Lys Leu Ala Phe Pro Gly Glu Thr Leu 
                165                 170                 175     


Ser Asp Ile Pro Cys Lys Thr Glu Glu Glu Gly Val Gly Cys Gly Gly 
            180                 185                 190         


Ala Gly Arg Arg Gly Asp Ser Gln Glu Cys Ser Pro Arg Ser Cys Pro 
        195                 200                 205             


Glu Leu Thr Ser Gly Pro Arg Met Cys Pro Arg Lys Glu Gln Asp Ser 
    210                 215                 220                 


Trp Ser Glu Ala Gly Gly Ile Leu Phe Lys Gly Lys Val Pro Met Val 
225                 230                 235                 240 


Val Leu Gln Asp Ile Leu Ala Val Arg Pro Pro Gln Ile Lys Ser Leu 
                245                 250                 255     


Pro Ala Thr Pro Gln Gly Lys Asn Met Thr Pro Glu Ser Glu Val Leu 
            260                 265                 270         


Glu Ser Phe Pro Glu Glu Asp Ser Val Leu Ser His Ser Ser Leu Ser 
        275                 280                 285             


Ser Pro Ser Ser Thr Ser Ser Pro Glu Gly Pro Pro Ala Pro Pro Lys 
    290                 295                 300                 


Gln His Ser Ser Thr Ser Pro Phe Pro Thr Ser Thr Pro Leu Arg Arg 
305                 310                 315                 320 


Ile Thr Lys Lys Phe Val Lys Gly Ser Thr Glu Lys Asn Lys Leu Arg 
                325                 330                 335     


Leu Gln Arg Asp Gln Glu Arg Leu Gly Lys Gln Leu Lys Leu Arg Ala 
            340                 345                 350         


Glu Arg Glu Glu Lys Glu Lys Leu Lys Glu Glu Ala Lys Arg Ala Lys 
        355                 360                 365             


Glu Glu Ala Lys Lys Lys Lys Glu Glu Glu Lys Glu Leu Lys Glu Lys 
    370                 375                 380                 


Glu Arg Arg Glu Lys Arg Glu Lys Asp Glu Lys Glu Lys Ala Glu Lys 
385                 390                 395                 400 


Gln Arg Leu Lys Glu Glu Arg Arg Lys Glu Arg Gln Glu Ala Leu Glu 
                405                 410                 415     


Ala Lys Leu Glu Glu Lys Arg Lys Lys Glu Glu Glu Lys Arg Leu Arg 
            420                 425                 430         


Glu Glu Glu Lys Arg Ile Lys Ala Glu Lys Ala Glu Ile Thr Arg Phe 
        435                 440                 445             


Phe Gln Lys Pro Lys Thr Pro Gln Ala Pro Lys Thr Leu Ala Gly Ser 
    450                 455                 460                 


Cys Gly Lys Phe Ala Pro Phe Glu Ile Lys Glu His Met Val Leu Ala 
465                 470                 475                 480 


Pro Arg Arg Arg Thr Ala Phe His Pro Asp Leu Cys Ser Gln Leu Asp 
                485                 490                 495     


Gln Leu Leu Gln Gln Gln Ser Gly Glu Phe Ser Phe Leu Lys Asp Leu 
            500                 505                 510         


Lys Gly Arg Gln Pro Leu Arg Ser Gly Pro Thr His Val Ser Thr Arg 
        515                 520                 525             


Asn Ala Asp Ile Phe Asn Ser Asp Val Val Ile Val Glu Arg Gly Lys 
    530                 535                 540                 


Gly Asp Gly Val Pro Glu Arg Arg Lys Phe Gly Arg Met Lys Leu Leu 
545                 550                 555                 560 


Gln Phe Cys Glu Asn His Arg Pro Ala Tyr Trp Gly Thr Trp Asn Lys 
                565                 570                 575     


Lys Thr Ala Leu Ile Arg Ala Arg Asp Pro Trp Ala Gln Asp Thr Lys 
            580                 585                 590         


Leu Leu Asp Tyr Glu Val Asp Ser Asp Glu Glu Trp Glu Glu Glu Glu 
        595                 600                 605             


Pro Gly Glu Ser Leu Ser His Ser Glu Gly Asp Asp Asp Asp Asp Met 
    610                 615                 620                 


Gly Glu Asp Glu Asp Glu Asp Asp Gly Phe Phe Val Pro His Gly Tyr 
625                 630                 635                 640 


Leu Ser Glu Asp Glu Gly Val Thr Glu Glu Cys Ala Asp Pro Glu Asn 
                645                 650                 655     


His Lys Val Arg Gln Lys Leu Lys Ala Lys Glu Trp Asp Glu Phe Leu 
            660                 665                 670         


Ala Lys Gly Lys Arg Phe Arg Val Leu Gln Pro Val Lys Ile Gly Cys 
        675                 680                 685             


Val Trp Ala Ala Asp Arg Asp Cys Ala Gly Asp Asp Leu Lys Val Leu 
    690                 695                 700                 


Gln Gln Phe Ala Ala Cys Phe Leu Glu Thr Leu Pro Ala Gln Glu Glu 
705                 710                 715                 720 


Gln Thr Pro Lys Ala Ser Lys Arg Glu Arg Arg Asp Glu Gln Ile Leu 
                725                 730                 735     


Ala Gln Leu Leu Pro Leu Leu His Gly Asn Val Asn Gly Ser Lys Val 
            740                 745                 750         


Ile Ile Arg Glu Phe Gln Glu His Cys Arg Arg Gly Leu Leu Ser Asn 
        755                 760                 765             


His Thr Gly Ser Pro Arg Ser Pro Ser Thr Thr Tyr Leu His Thr Pro 
    770                 775                 780                 


Thr Pro Ser Glu Asp Ala Ala Ile Pro Ser Lys Ser Arg Leu Lys Arg 
785                 790                 795                 800 


Leu Ile Ser Glu Asn Ser Val Tyr Glu Lys Arg Pro Asp Phe Arg Met 
                805                 810                 815     


Cys Trp Tyr Val His Pro Gln Val Leu Gln Ser Phe Gln Gln Glu His 
            820                 825                 830         


Leu Pro Val Pro Cys Gln Trp Ser Tyr Val Thr Ser Val Pro Ser Ala 
        835                 840                 845             


Pro Lys Glu Asp Ser Gly Ser Val Pro Ser Thr Gly Pro Ser Gln Gly 
    850                 855                 860                 


Thr Pro Ile Ser Leu Lys Arg Lys Ser Ala Gly Ser Met Cys Ile Thr 
865                 870                 875                 880 


Gln Phe Met Lys Lys Arg Arg His Asp Gly Gln Ile Gly Ala Glu Asp 
                885                 890                 895     


Met Asp Gly Phe Gln Ala Asp Thr Glu Glu Glu Glu Glu Glu Glu Gly 
            900                 905                 910         


Asp Cys Met Ile Val Asp Val Pro Asp Ala Ala Glu Val Gln Ala Pro 
        915                 920                 925             


Cys Gly Ala Ala Ser Gly Ala Gly Gly Gly Val Gly Val Asp Thr Gly 
    930                 935                 940                 


Lys Ala Thr Leu Thr Ala Ser Pro Leu Gly Ala Ser 
945                 950                 955     


<210>  2102
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAF1B__Homo_sapiens__NP_005432

<400>  2102

Met Lys Val Ile Thr Cys Glu Ile Ala Trp His Asn Lys Glu Pro Val 
1               5                   10                  15      


Tyr Ser Leu Asp Phe Gln His Gly Thr Ala Gly Arg Ile His Arg Leu 
            20                  25                  30          


Ala Ser Ala Gly Val Asp Thr Asn Val Arg Ile Trp Lys Val Glu Lys 
        35                  40                  45              


Gly Pro Asp Gly Lys Ala Ile Val Glu Phe Leu Ser Asn Leu Ala Arg 
    50                  55                  60                  


His Thr Lys Ala Val Asn Val Val Arg Phe Ser Pro Thr Gly Glu Ile 
65                  70                  75                  80  


Leu Ala Ser Gly Gly Asp Asp Ala Val Ile Leu Leu Trp Lys Val Asn 
                85                  90                  95      


Asp Asn Lys Glu Pro Glu Gln Ile Ala Phe Gln Asp Glu Asp Glu Ala 
            100                 105                 110         


Gln Leu Asn Lys Glu Asn Trp Thr Val Val Lys Thr Leu Arg Gly His 
        115                 120                 125             


Leu Glu Asp Val Tyr Asp Ile Cys Trp Ala Thr Asp Gly Asn Leu Met 
    130                 135                 140                 


Ala Ser Ala Ser Val Asp Asn Thr Ala Ile Ile Trp Asp Val Ser Lys 
145                 150                 155                 160 


Gly Gln Lys Ile Ser Ile Phe Asn Glu His Lys Ser Tyr Val Gln Gly 
                165                 170                 175     


Val Thr Trp Asp Pro Leu Gly Gln Tyr Val Ala Thr Leu Ser Cys Asp 
            180                 185                 190         


Arg Val Leu Arg Val Tyr Ser Ile Gln Lys Lys Arg Val Ala Phe Asn 
        195                 200                 205             


Val Ser Lys Met Leu Ser Gly Ile Gly Ala Glu Gly Glu Ala Arg Ser 
    210                 215                 220                 


Tyr Arg Met Phe His Asp Asp Ser Met Lys Ser Phe Phe Arg Arg Leu 
225                 230                 235                 240 


Ser Phe Thr Pro Asp Gly Ser Leu Leu Leu Thr Pro Ala Gly Cys Val 
                245                 250                 255     


Glu Ser Gly Glu Asn Val Met Asn Thr Thr Tyr Val Phe Ser Arg Lys 
            260                 265                 270         


Asn Leu Lys Arg Pro Ile Ala His Leu Pro Cys Pro Gly Lys Ala Thr 
        275                 280                 285             


Leu Ala Val Arg Cys Cys Pro Val Tyr Phe Glu Leu Arg Pro Val Val 
    290                 295                 300                 


Glu Thr Gly Val Glu Leu Met Ser Leu Pro Tyr Arg Leu Val Phe Ala 
305                 310                 315                 320 


Val Ala Ser Glu Asp Ser Val Leu Leu Tyr Asp Thr Gln Gln Ser Phe 
                325                 330                 335     


Pro Phe Gly Tyr Val Ser Asn Ile His Tyr His Thr Leu Ser Asp Ile 
            340                 345                 350         


Ser Trp Ser Ser Asp Gly Ala Phe Leu Ala Ile Ser Ser Thr Asp Gly 
        355                 360                 365             


Tyr Cys Ser Phe Val Thr Phe Glu Lys Asp Glu Leu Gly Ile Pro Leu 
    370                 375                 380                 


Lys Glu Lys Pro Val Leu Asn Met Arg Thr Pro Asp Thr Ala Lys Lys 
385                 390                 395                 400 


Thr Lys Ser Gln Thr His Arg Gly Ser Ser Pro Gly Pro Arg Pro Val 
                405                 410                 415     


Glu Gly Thr Pro Ala Ser Arg Thr Gln Asp Pro Ser Ser Pro Gly Thr 
            420                 425                 430         


Thr Pro Pro Gln Ala Arg Gln Ala Pro Ala Pro Thr Val Ile Arg Asp 
        435                 440                 445             


Pro Pro Ser Ile Thr Pro Ala Val Lys Ser Pro Leu Pro Gly Pro Ser 
    450                 455                 460                 


Glu Glu Lys Thr Leu Gln Pro Ser Ser Gln Asn Thr Lys Ala His Pro 
465                 470                 475                 480 


Ser Arg Arg Val Thr Leu Asn Thr Leu Gln Ala Trp Ser Lys Thr Thr 
                485                 490                 495     


Pro Arg Arg Ile Asn Leu Thr Pro Leu Lys Thr Asp Thr Pro Pro Ser 
            500                 505                 510         


Ser Val Pro Thr Ser Val Ile Ser Thr Pro Ser Thr Glu Glu Ile Gln 
        515                 520                 525             


Ser Glu Thr Pro Gly Asp Ala Gln Gly Ser Pro Pro Glu Leu Lys Arg 
    530                 535                 540                 


Pro Arg Leu Asp Glu Asn Lys Gly Gly Thr Glu Ser Leu Asp Pro 
545                 550                 555                 


<210>  2103
<211>  812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAMP1__Homo_sapiens__NP_001157617

<400>  2103

Met Glu Ala Phe Gln Glu Leu Arg Lys Pro Ser Ala Arg Leu Glu Cys 
1               5                   10                  15      


Asp His Cys Ser Phe Arg Gly Thr Asp Tyr Glu Asn Val Gln Ile His 
            20                  25                  30          


Met Gly Thr Ile His Pro Glu Phe Cys Asp Glu Met Asp Ala Gly Gly 
        35                  40                  45              


Leu Gly Lys Met Ile Phe Tyr Gln Lys Ser Ala Lys Leu Phe His Cys 
    50                  55                  60                  


His Lys Cys Phe Phe Thr Ser Lys Met Tyr Ser Asn Val Tyr Tyr His 
65                  70                  75                  80  


Ile Thr Ser Lys His Ala Ser Pro Asp Lys Trp Asn Asp Lys Pro Lys 
                85                  90                  95      


Asn Gln Leu Asn Lys Glu Thr Asp Pro Val Lys Ser Pro Pro Leu Pro 
            100                 105                 110         


Glu His Gln Lys Ile Pro Cys Asn Ser Ala Glu Pro Lys Ser Ile Pro 
        115                 120                 125             


Ala Leu Ser Met Glu Thr Gln Lys Leu Gly Ser Val Leu Ser Pro Glu 
    130                 135                 140                 


Ser Pro Lys Pro Thr Pro Leu Thr Pro Leu Glu Pro Gln Lys Pro Gly 
145                 150                 155                 160 


Ser Val Val Ser Pro Glu Leu Gln Thr Pro Leu Pro Ser Pro Glu Pro 
                165                 170                 175     


Ser Lys Pro Ala Ser Val Ser Ser Pro Glu Pro Pro Lys Ser Val Pro 
            180                 185                 190         


Val Cys Glu Ser Gln Lys Leu Ala Pro Val Pro Ser Pro Glu Pro Gln 
        195                 200                 205             


Lys Pro Ala Pro Val Ser Pro Glu Ser Val Lys Ala Thr Leu Ser Asn 
    210                 215                 220                 


Pro Lys Pro Gln Lys Gln Ser His Phe Pro Glu Thr Leu Gly Pro Pro 
225                 230                 235                 240 


Ser Ala Ser Ser Pro Glu Ser Pro Val Leu Ala Ala Ser Pro Glu Pro 
                245                 250                 255     


Trp Gly Pro Ser Pro Ala Ala Ser Pro Glu Ser Arg Lys Ser Ala Arg 
            260                 265                 270         


Thr Thr Ser Pro Glu Pro Arg Lys Pro Ser Pro Ser Glu Ser Pro Glu 
        275                 280                 285             


Pro Trp Lys Pro Phe Pro Ala Val Ser Pro Glu Pro Arg Arg Pro Ala 
    290                 295                 300                 


Pro Ala Val Ser Pro Gly Ser Trp Lys Pro Gly Pro Pro Gly Ser Pro 
305                 310                 315                 320 


Arg Pro Trp Lys Ser Asn Pro Ser Ala Ser Ser Gly Pro Trp Lys Pro 
                325                 330                 335     


Ala Lys Pro Ala Pro Ser Val Ser Pro Gly Pro Trp Lys Pro Ile Pro 
            340                 345                 350         


Ser Val Ser Pro Gly Pro Trp Lys Pro Thr Pro Ser Val Ser Ser Ala 
        355                 360                 365             


Ser Trp Lys Ser Ser Ser Val Ser Pro Ser Ser Trp Lys Ser Pro Pro 
    370                 375                 380                 


Ala Ser Pro Glu Ser Trp Lys Ser Gly Pro Pro Glu Leu Arg Lys Thr 
385                 390                 395                 400 


Ala Pro Thr Leu Ser Pro Glu His Trp Lys Ala Val Pro Pro Val Ser 
                405                 410                 415     


Pro Glu Leu Arg Lys Pro Gly Pro Pro Leu Ser Pro Glu Ile Arg Ser 
            420                 425                 430         


Pro Ala Gly Ser Pro Glu Leu Arg Lys Pro Ser Gly Ser Pro Asp Leu 
        435                 440                 445             


Trp Lys Leu Ser Pro Asp Gln Arg Lys Thr Ser Pro Ala Ser Leu Asp 
    450                 455                 460                 


Phe Pro Glu Ser Gln Lys Ser Ser Arg Gly Gly Ser Pro Asp Leu Trp 
465                 470                 475                 480 


Lys Ser Ser Phe Phe Ile Glu Pro Gln Lys Pro Val Phe Pro Glu Thr 
                485                 490                 495     


Arg Lys Pro Gly Pro Ser Gly Pro Ser Glu Ser Pro Lys Ala Ala Ser 
            500                 505                 510         


Asp Ile Trp Lys Pro Val Leu Ser Ile Asp Thr Glu Pro Arg Lys Pro 
        515                 520                 525             


Ala Leu Phe Pro Glu Pro Ala Lys Thr Ala Pro Pro Ala Ser Pro Glu 
    530                 535                 540                 


Ala Arg Lys Arg Ala Leu Phe Pro Glu Pro Arg Lys His Ala Leu Phe 
545                 550                 555                 560 


Pro Glu Leu Pro Lys Ser Ala Leu Phe Ser Glu Ser Gln Lys Ala Val 
                565                 570                 575     


Glu Leu Gly Asp Glu Leu Gln Ile Asp Ala Ile Asp Asp Gln Lys Cys 
            580                 585                 590         


Asp Ile Leu Val Gln Glu Glu Leu Leu Ala Ser Pro Lys Lys Leu Leu 
        595                 600                 605             


Glu Asp Thr Leu Phe Pro Ser Ser Lys Lys Leu Lys Lys Asp Asn Gln 
    610                 615                 620                 


Glu Ser Ser Asp Ala Glu Leu Ser Ser Ser Glu Tyr Ile Lys Thr Asp 
625                 630                 635                 640 


Leu Asp Ala Met Asp Ile Lys Gly Gln Glu Ser Ser Ser Asp Gln Glu 
                645                 650                 655     


Gln Val Asp Val Glu Ser Ile Asp Phe Ser Lys Glu Asn Lys Met Asp 
            660                 665                 670         


Met Thr Ser Pro Glu Gln Ser Arg Asn Val Leu Gln Phe Thr Glu Glu 
        675                 680                 685             


Lys Glu Ala Phe Ile Ser Glu Glu Glu Ile Ala Lys Tyr Met Lys Arg 
    690                 695                 700                 


Gly Lys Gly Lys Tyr Tyr Cys Lys Ile Cys Cys Cys Arg Ala Met Lys 
705                 710                 715                 720 


Lys Gly Ala Val Leu His His Leu Val Asn Lys His Asn Val His Ser 
                725                 730                 735     


Pro Tyr Lys Cys Thr Ile Cys Gly Lys Ala Phe Leu Leu Glu Ser Leu 
            740                 745                 750         


Leu Lys Asn His Val Ala Ala His Gly Gln Ser Leu Leu Lys Cys Pro 
        755                 760                 765             


Arg Cys Asn Phe Glu Ser Asn Phe Pro Arg Gly Phe Lys Lys His Leu 
    770                 775                 780                 


Thr His Cys Gln Ser Arg His Asn Glu Glu Ala Asn Lys Lys Leu Met 
785                 790                 795                 800 


Glu Ala Leu Glu Pro Pro Leu Glu Glu Gln Gln Ile 
                805                 810         


<210>  2104
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAT__Homo_sapiens__NP_001136401

<400>  2104

Met Ala Ala Lys Thr Pro Ser Ser Glu Glu Ser Gly Leu Pro Lys Leu 
1               5                   10                  15      


Pro Val Pro Pro Leu Gln Gln Thr Leu Ala Thr Tyr Leu Gln Cys Met 
            20                  25                  30          


Arg His Leu Val Ser Glu Glu Gln Phe Arg Lys Ser Gln Ala Ile Val 
        35                  40                  45              


Gln Gln Phe Gly Ala Pro Gly Gly Leu Gly Glu Thr Leu Gln Gln Lys 
    50                  55                  60                  


Leu Leu Glu Arg Gln Glu Lys Thr Ala Asn Trp Val Ser Glu Tyr Trp 
65                  70                  75                  80  


Leu Asn Asp Met Tyr Leu Asn Asn Arg Leu Ala Leu Pro Val Asn Ser 
                85                  90                  95      


Ser Pro Ala Val Ile Phe Ala Arg Gln His Phe Pro Gly Thr Asp Asp 
            100                 105                 110         


Gln Leu Arg Phe Ala Ala Ser Leu Ile Ser Gly Val Leu Ser Tyr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ser His Ser Ile Pro Thr Asp Cys Ala Lys Gly Gln 
    130                 135                 140                 


Leu Ser Gly Gln Pro Leu Cys Met Lys Gln Tyr Tyr Gly Leu Phe Ser 
145                 150                 155                 160 


Ser Tyr Arg Leu Pro Gly His Thr Gln Asp Thr Leu Val Ala Gln Asn 
                165                 170                 175     


Ser Ser Ile Met Pro Glu Pro Glu His Val Ile Val Ala Cys Cys Asn 
            180                 185                 190         


Gln Phe Phe Val Leu Asp Val Val Ile Asn Phe Arg Arg Leu Ser Glu 
        195                 200                 205             


Gly Asp Leu Phe Thr Gln Leu Arg Lys Ile Val Lys Met Ala Ser Asn 
    210                 215                 220                 


Glu Asp Glu Arg Leu Pro Pro Ile Gly Leu Leu Thr Ser Asp Gly Arg 
225                 230                 235                 240 


Ser Glu Trp Ala Glu Ala Arg Thr Val Leu Val Lys Asp Ser Thr Asn 
                245                 250                 255     


Arg Asp Ser Leu Asp Met Ile Glu Arg Cys Ile Cys Leu Val Cys Leu 
            260                 265                 270         


Asp Ala Pro Gly Gly Val Glu Leu Ser Asp Thr His Arg Ala Leu Gln 
        275                 280                 285             


Leu Leu His Gly Gly Gly Tyr Ser Lys Asn Gly Ala Asn Arg Trp Tyr 
    290                 295                 300                 


Asp Lys Ser Leu Gln Phe Val Val Gly Arg Asp Gly Thr Cys Gly Val 
305                 310                 315                 320 


Val Cys Glu His Ser Pro Phe Asp Gly Ile Val Leu Val Gln Cys Thr 
                325                 330                 335     


Glu His Leu Leu Lys His Met Thr Gln Ser Ser Arg Lys Leu Ile Arg 
            340                 345                 350         


Ala Asp Ser Val Ser Glu Leu Pro Ala Pro Arg Arg Leu Arg Trp Lys 
        355                 360                 365             


Cys Ser Pro Glu Ile Gln Gly His Leu Ala Ser Ser Ala Glu Lys Leu 
    370                 375                 380                 


Gln Arg Ile Val Lys Asn Leu Asp Phe Ile Val Tyr Lys Phe Asp Asn 
385                 390                 395                 400 


Tyr Gly Lys Thr Phe Ile Lys Lys Gln Lys Cys Ser Pro Asp Ala Phe 
                405                 410                 415     


Ile Gln Val Ala Leu Gln Leu Ala Phe Tyr Arg Leu His Arg Arg Leu 
            420                 425                 430         


Val Pro Thr Tyr Glu Ser Ala Ser Ile Arg Arg Phe Gln Glu Gly Arg 
        435                 440                 445             


Val Asp Asn Ile Arg Ser Ala Thr Pro Glu Ala Leu Ala Phe Val Arg 
    450                 455                 460                 


Ala Val Thr Asp His Lys Ala Ala Val Pro Ala Ser Glu Lys Leu Leu 
465                 470                 475                 480 


Leu Leu Lys Asp Ala Ile Arg Ala Gln Thr Ala Tyr Thr Val Met Ala 
                485                 490                 495     


Ile Thr Gly Met Ala Ile Asp Asn His Leu Leu Ala Leu Arg Glu Leu 
            500                 505                 510         


Ala Arg Ala Met Cys Lys Glu Leu Pro Glu Met Phe Met Asp Glu Thr 
        515                 520                 525             


Tyr Leu Met Ser Asn Arg Phe Val Leu Ser Thr Ser Gln Val Pro Thr 
    530                 535                 540                 


Thr Thr Glu Met Phe Cys Cys Tyr Gly Pro Val Val Pro Asn Gly Tyr 
545                 550                 555                 560 


Gly Ala Cys Tyr Asn Pro Gln Pro Glu Thr Ile Leu Phe Cys Ile Ser 
                565                 570                 575     


Ser Phe His Ser Cys Lys Glu Thr Ser Ser Ser Lys Phe Ala Lys Ala 
            580                 585                 590         


Val Glu Glu Ser Leu Ile Asp Met Arg Asp Leu Cys Ser Leu Leu Pro 
        595                 600                 605             


Pro Thr Glu Ser Lys Pro Leu Ala Thr Lys Glu Lys Ala Thr Arg Pro 
    610                 615                 620                 


Ser Gln Gly His Gln Pro 
625                 630 


<210>  2105
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHCHD10__Homo_sapiens__NP_998885

<400>  2105

Met Pro Arg Gly Ser Arg Ser Ala Ala Ser Arg Pro Ala Ser Arg Pro 
1               5                   10                  15      


Ala Ala Pro Ser Ala His Pro Pro Ala His Pro Pro Pro Ser Ala Ala 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ser Gly Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Val 
    50                  55                  60                  


Met Gly Ser Ala Leu Thr Gly Ala Phe Ser Gly Gly Ser Ser Glu Pro 
65                  70                  75                  80  


Ser Gln Pro Ala Val Gln Gln Ala Pro Thr Pro Ala Ala Pro Gln Pro 
                85                  90                  95      


Leu Gln Met Gly Pro Cys Ala Tyr Glu Ile Arg Gln Phe Leu Asp Cys 
            100                 105                 110         


Ser Thr Thr Gln Ser Asp Leu Ser Leu Cys Glu Gly Phe Ser Glu Ala 
        115                 120                 125             


Leu Lys Gln Cys Lys Tyr Tyr His Gly Leu Ser Ser Leu Pro 
    130                 135                 140         


<210>  2106
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHCHD1__Homo_sapiens__NP_976043

<400>  2106

Met Ala Thr Pro Ser Leu Arg Gly Arg Leu Ala Arg Phe Gly Asn Pro 
1               5                   10                  15      


Arg Lys Pro Val Leu Lys Pro Asn Lys Pro Leu Ile Leu Ala Asn Arg 
            20                  25                  30          


Val Gly Glu Arg Arg Arg Glu Lys Gly Glu Ala Thr Cys Ile Thr Glu 
        35                  40                  45              


Met Ser Val Met Met Ala Cys Trp Lys Gln Asn Glu Phe Arg Asp Asp 
    50                  55                  60                  


Ala Cys Arg Lys Glu Ile Gln Gly Phe Leu Asp Cys Ala Ala Arg Ala 
65                  70                  75                  80  


Gln Glu Ala Arg Lys Met Arg Ser Ile Gln Glu Thr Leu Gly Glu Ser 
                85                  90                  95      


Gly Ser Leu Leu Pro Asn Lys Leu Asn Lys Leu Leu Gln Arg Phe Pro 
            100                 105                 110         


Asn Lys Pro Tyr Leu Ser 
        115             


<210>  2107
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHCHD3__Homo_sapiens__NP_060282

<400>  2107

Met Gly Gly Thr Thr Ser Thr Arg Arg Val Thr Phe Glu Ala Asp Glu 
1               5                   10                  15      


Asn Glu Asn Ile Thr Val Val Lys Gly Ile Arg Leu Ser Glu Asn Val 
            20                  25                  30          


Ile Asp Arg Met Lys Glu Ser Ser Pro Ser Gly Ser Lys Ser Gln Arg 
        35                  40                  45              


Tyr Ser Gly Ala Tyr Gly Ala Ser Val Ser Asp Glu Glu Leu Lys Arg 
    50                  55                  60                  


Arg Val Ala Glu Glu Leu Ala Leu Glu Gln Ala Lys Lys Glu Ser Glu 
65                  70                  75                  80  


Asp Gln Lys Arg Leu Lys Gln Ala Lys Glu Leu Asp Arg Glu Arg Ala 
                85                  90                  95      


Ala Ala Asn Glu Gln Leu Thr Arg Ala Ile Leu Arg Glu Arg Ile Cys 
            100                 105                 110         


Ser Glu Glu Glu Arg Ala Lys Ala Lys His Leu Ala Arg Gln Leu Glu 
        115                 120                 125             


Glu Lys Asp Arg Val Leu Lys Lys Gln Asp Ala Phe Tyr Lys Glu Gln 
    130                 135                 140                 


Leu Ala Arg Leu Glu Glu Arg Ser Ser Glu Phe Tyr Arg Val Thr Thr 
145                 150                 155                 160 


Glu Gln Tyr Gln Lys Ala Ala Glu Glu Val Glu Ala Lys Phe Lys Arg 
                165                 170                 175     


Tyr Glu Ser His Pro Val Cys Ala Asp Leu Gln Ala Lys Ile Leu Gln 
            180                 185                 190         


Cys Tyr Arg Glu Asn Thr His Gln Thr Leu Lys Cys Ser Ala Leu Ala 
        195                 200                 205             


Thr Gln Tyr Met His Cys Val Asn His Ala Lys Gln Ser Met Leu Glu 
    210                 215                 220                 


Lys Gly Gly 
225         


<210>  2108
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHCHD5__Homo_sapiens__NP_115685

<400>  2108

Met Gln Ala Ala Leu Glu Val Thr Ala Arg Tyr Cys Gly Arg Glu Leu 
1               5                   10                  15      


Glu Gln Tyr Gly Gln Cys Val Ala Ala Lys Pro Glu Ser Trp Gln Arg 
            20                  25                  30          


Asp Cys His Tyr Leu Lys Met Ser Ile Ala Gln Cys Thr Ser Ser His 
        35                  40                  45              


Pro Ile Ile Arg Gln Ile Arg Gln Ala Cys Ala Gln Pro Phe Glu Ala 
    50                  55                  60                  


Phe Glu Glu Cys Leu Arg Gln Asn Glu Ala Ala Val Gly Asn Cys Ala 
65                  70                  75                  80  


Glu His Met Arg Arg Phe Leu Gln Cys Ala Glu Gln Val Gln Pro Pro 
                85                  90                  95      


Arg Ser Pro Ala Thr Val Glu Ala Gln Pro Leu Pro Ala Ser 
            100                 105                 110 


<210>  2109
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHCHD6__Homo_sapiens__NP_115719

<400>  2109

Met Gly Ser Thr Glu Ser Ser Glu Gly Arg Arg Val Ser Phe Gly Val 
1               5                   10                  15      


Asp Glu Glu Glu Arg Val Arg Val Leu Gln Gly Val Arg Leu Ser Glu 
            20                  25                  30          


Asn Val Val Asn Arg Met Lys Glu Pro Ser Ser Pro Pro Pro Ala Pro 
        35                  40                  45              


Thr Ser Ser Thr Phe Gly Leu Gln Asp Gly Asn Leu Arg Ala Pro His 
    50                  55                  60                  


Lys Glu Ser Thr Leu Pro Arg Ser Gly Ser Ser Gly Gly Gln Gln Pro 
65                  70                  75                  80  


Ser Gly Met Lys Glu Gly Val Lys Arg Tyr Glu Gln Glu His Ala Ala 
                85                  90                  95      


Ile Gln Asp Lys Leu Phe Gln Val Ala Lys Arg Glu Arg Glu Ala Ala 
            100                 105                 110         


Thr Lys His Ser Lys Ala Ser Leu Pro Thr Gly Glu Gly Ser Ile Ser 
        115                 120                 125             


His Glu Glu Gln Lys Ser Val Arg Leu Ala Arg Glu Leu Glu Ser Arg 
    130                 135                 140                 


Glu Ala Glu Leu Arg Arg Arg Asp Thr Phe Tyr Lys Glu Gln Leu Glu 
145                 150                 155                 160 


Arg Ile Glu Arg Lys Asn Ala Glu Met Tyr Lys Leu Ser Ser Glu Gln 
                165                 170                 175     


Phe His Glu Ala Ala Ser Lys Met Glu Ser Thr Ile Lys Pro Arg Arg 
            180                 185                 190         


Val Glu Pro Val Cys Ser Gly Leu Gln Ala Gln Ile Leu His Cys Tyr 
        195                 200                 205             


Arg Asp Arg Pro His Glu Val Leu Leu Cys Ser Asp Leu Val Lys Ala 
    210                 215                 220                 


Tyr Gln Arg Cys Val Ser Ala Ala His Lys Gly 
225                 230                 235 


<210>  2110
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHCHD7__Homo_sapiens__NP_001011668

<400>  2110

Met Lys Cys Glu Glu Thr His Ala Pro Asn Ser Asn Trp Val Tyr Val 
1               5                   10                  15      


Met Leu Pro Ser Lys Lys Thr Val Arg Met Pro Ser Val Thr Gln Arg 
            20                  25                  30          


Leu Arg Asp Pro Asp Ile Asn Pro Cys Leu Ser Glu Ser Asp Ala Ser 
        35                  40                  45              


Thr Arg Cys Leu Asp Glu Asn Asn Tyr Asp Arg Glu Arg Cys Ser Thr 
    50                  55                  60                  


Tyr Phe Leu Arg Tyr Lys Asn Cys Arg Arg Phe Trp Asn Ser Ile Val 
65                  70                  75                  80  


Met Gln Arg Arg Lys Asn Gly Val Lys Pro Phe Met Pro Thr Ala Ala 
                85                  90                  95      


Glu Arg Asp Glu Ile Leu Arg Ala Val Gly Asn Met Pro Tyr 
            100                 105                 110 


<210>  2111
<211>  1798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHD1__Homo_sapiens__XP_005271923

<400>  2111

Met Asn Gly His Ser Asp Glu Glu Ser Val Arg Asn Ser Ser Gly Glu 
1               5                   10                  15      


Ser Ser Gln Ser Asp Asp Asp Ser Gly Ser Ala Ser Gly Ser Gly Ser 
            20                  25                  30          


Gly Ser Ser Ser Gly Ser Ser Ser Asp Gly Ser Ser Ser Gln Ser Gly 
        35                  40                  45              


Ser Ser Asp Ser Asp Ser Gly Ser Glu Ser Gly Ser Gln Ser Glu Ser 
    50                  55                  60                  


Glu Ser Asp Thr Ser Arg Glu Asn Lys Val Gln Ala Lys Pro Pro Lys 
65                  70                  75                  80  


Val Asp Gly Ala Glu Phe Trp Lys Ser Ser Pro Ser Ile Leu Ala Val 
                85                  90                  95      


Gln Arg Ser Ala Ile Leu Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln His Gln Ala Ser Ser Asn Ser Gly Ser Glu Glu Asp Ser Ser Ser 
        115                 120                 125             


Ser Glu Asp Ser Asp Asp Ser Ser Ser Glu Val Lys Arg Lys Lys His 
    130                 135                 140                 


Lys Asp Glu Asp Trp Gln Met Ser Gly Ser Gly Ser Pro Ser Gln Ser 
145                 150                 155                 160 


Gly Ser Asp Ser Glu Ser Glu Glu Glu Arg Glu Lys Ser Ser Cys Asp 
                165                 170                 175     


Glu Thr Glu Ser Asp Tyr Glu Pro Lys Asn Lys Val Lys Ser Arg Lys 
            180                 185                 190         


Pro Gln Asn Arg Ser Lys Ser Lys Asn Gly Lys Lys Ile Leu Gly Gln 
        195                 200                 205             


Lys Lys Arg Gln Ile Asp Ser Ser Glu Glu Asp Asp Asp Glu Glu Asp 
    210                 215                 220                 


Tyr Asp Asn Asp Lys Arg Ser Ser Arg Arg Gln Ala Thr Val Asn Val 
225                 230                 235                 240 


Ser Tyr Lys Glu Asp Glu Glu Met Lys Thr Asp Ser Asp Asp Leu Leu 
                245                 250                 255     


Glu Val Cys Gly Glu Asp Val Pro Gln Pro Glu Glu Glu Glu Phe Glu 
            260                 265                 270         


Thr Ile Glu Arg Phe Met Asp Cys Arg Ile Gly Arg Lys Gly Ala Thr 
        275                 280                 285             


Gly Ala Thr Thr Thr Ile Tyr Ala Val Glu Ala Asp Gly Asp Pro Asn 
    290                 295                 300                 


Ala Gly Phe Glu Lys Asn Lys Glu Pro Gly Glu Ile Gln Tyr Leu Ile 
305                 310                 315                 320 


Lys Trp Lys Gly Trp Ser His Ile His Asn Thr Trp Glu Thr Glu Glu 
                325                 330                 335     


Thr Leu Lys Gln Gln Asn Val Arg Gly Met Lys Lys Leu Asp Asn Tyr 
            340                 345                 350         


Lys Lys Lys Asp Gln Glu Thr Lys Arg Trp Leu Lys Asn Ala Ser Pro 
        355                 360                 365             


Glu Asp Val Glu Tyr Tyr Asn Cys Gln Gln Glu Leu Thr Asp Asp Leu 
    370                 375                 380                 


His Lys Gln Tyr Gln Ile Val Glu Arg Ile Ile Ala His Ser Asn Gln 
385                 390                 395                 400 


Lys Ser Ala Ala Gly Tyr Pro Asp Tyr Tyr Cys Lys Trp Gln Gly Leu 
                405                 410                 415     


Pro Tyr Ser Glu Cys Ser Trp Glu Asp Gly Ala Leu Ile Ser Lys Lys 
            420                 425                 430         


Phe Gln Ala Cys Ile Asp Glu Tyr Phe Ser Arg Asn Gln Ser Lys Thr 
        435                 440                 445             


Thr Pro Phe Lys Asp Cys Lys Val Leu Lys Gln Arg Pro Arg Phe Val 
    450                 455                 460                 


Ala Leu Lys Lys Gln Pro Ser Tyr Ile Gly Gly His Glu Gly Leu Glu 
465                 470                 475                 480 


Leu Arg Asp Tyr Gln Leu Asn Gly Leu Asn Trp Leu Ala His Ser Trp 
                485                 490                 495     


Cys Lys Gly Asn Ser Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys 
            500                 505                 510         


Thr Ile Gln Thr Ile Ser Phe Leu Asn Tyr Leu Phe His Glu His Gln 
        515                 520                 525             


Leu Tyr Gly Pro Phe Leu Leu Val Val Pro Leu Ser Thr Leu Thr Ser 
    530                 535                 540                 


Trp Gln Arg Glu Ile Gln Thr Trp Ala Ser Gln Met Asn Ala Val Val 
545                 550                 555                 560 


Tyr Leu Gly Asp Ile Asn Ser Arg Asn Met Ile Arg Thr His Glu Trp 
                565                 570                 575     


Thr His His Gln Thr Lys Arg Leu Lys Phe Asn Ile Leu Leu Thr Thr 
            580                 585                 590         


Tyr Glu Ile Leu Leu Lys Asp Lys Ala Phe Leu Gly Gly Leu Asn Trp 
        595                 600                 605             


Ala Phe Ile Gly Val Asp Glu Ala His Arg Leu Lys Asn Asp Asp Ser 
    610                 615                 620                 


Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His Arg Leu Leu 
625                 630                 635                 640 


Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu Trp Ser Leu 
                645                 650                 655     


Leu His Phe Ile Met Pro Glu Lys Phe Ser Ser Trp Glu Asp Phe Glu 
            660                 665                 670         


Glu Glu His Gly Lys Gly Arg Glu Tyr Gly Tyr Ala Ser Leu His Lys 
        675                 680                 685             


Glu Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp Val Glu Lys 
    690                 695                 700                 


Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Met Glu Met Ser Ala 
705                 710                 715                 720 


Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn Tyr Lys Ala 
                725                 730                 735     


Leu Ser Lys Gly Ser Lys Gly Ser Thr Ser Gly Phe Leu Asn Ile Met 
            740                 745                 750         


Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile Lys Pro Pro 
        755                 760                 765             


Asp Asn Asn Glu Phe Tyr Asn Lys Gln Glu Ala Leu Gln His Leu Ile 
    770                 775                 780                 


Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu Ile Arg Leu 
785                 790                 795                 800 


Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met Val Arg Met 
                805                 810                 815     


Leu Asp Ile Leu Ala Glu Tyr Leu Lys Tyr Arg Gln Phe Pro Phe Gln 
            820                 825                 830         


Arg Leu Asp Gly Ser Ile Lys Gly Glu Leu Arg Lys Gln Ala Leu Asp 
        835                 840                 845             


His Phe Asn Ala Glu Gly Ser Glu Asp Phe Cys Phe Leu Leu Ser Thr 
    850                 855                 860                 


Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Thr Val Val 
865                 870                 875                 880 


Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala 
                885                 890                 895     


Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr Arg Leu 
            900                 905                 910         


Val Thr Lys Gly Ser Val Glu Glu Asp Ile Leu Glu Arg Ala Lys Lys 
        915                 920                 925             


Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp Thr Thr Gly 
    930                 935                 940                 


Lys Thr Val Leu His Thr Gly Ser Ala Pro Ser Ser Ser Thr Pro Phe 
945                 950                 955                 960 


Asn Lys Glu Glu Leu Ser Ala Ile Leu Lys Phe Gly Ala Glu Glu Leu 
                965                 970                 975     


Phe Lys Glu Pro Glu Gly Glu Glu Gln Glu Pro Gln Glu Met Asp Ile 
            980                 985                 990         


Asp Glu Ile Leu Lys Arg Ala Glu  Thr His Glu Asn Glu  Pro Gly Pro 
        995                 1000                 1005             


Leu Thr  Val Gly Asp Glu Leu  Leu Ser Gln Phe Lys  Val Ala Asn 
    1010                 1015                 1020             


Phe Ser  Asn Met Asp Glu Asp  Asp Ile Glu Leu Glu  Pro Glu Arg 
    1025                 1030                 1035             


Asn Ser  Lys Asn Trp Glu Glu  Ile Ile Pro Glu Asp  Gln Arg Arg 
    1040                 1045                 1050             


Arg Leu  Glu Glu Glu Glu Arg  Gln Lys Glu Leu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Met Leu  Pro Arg Met Arg Asn  Cys Ala Lys Gln Ile  Ser Phe Asn 
    1070                 1075                 1080             


Gly Ser  Glu Gly Arg Arg Ser  Arg Ser Arg Arg Tyr  Ser Gly Ser 
    1085                 1090                 1095             


Asp Ser  Asp Ser Ile Ser Glu  Gly Lys Arg Pro Lys  Lys Arg Gly 
    1100                 1105                 1110             


Arg Pro  Arg Thr Ile Pro Arg  Glu Asn Ile Lys Gly  Phe Ser Asp 
    1115                 1120                 1125             


Ala Glu  Ile Arg Arg Phe Ile  Lys Ser Tyr Lys Lys  Phe Gly Gly 
    1130                 1135                 1140             


Pro Leu  Glu Arg Leu Asp Ala  Ile Ala Arg Asp Ala  Glu Leu Val 
    1145                 1150                 1155             


Asp Lys  Ser Glu Thr Asp Leu  Arg Arg Leu Gly Glu  Leu Val His 
    1160                 1165                 1170             


Asn Gly  Cys Ile Lys Ala Leu  Lys Asp Ser Ser Ser  Gly Thr Glu 
    1175                 1180                 1185             


Arg Thr  Gly Gly Arg Leu Gly  Lys Val Lys Gly Pro  Thr Phe Arg 
    1190                 1195                 1200             


Ile Ser  Gly Val Gln Val Asn  Ala Lys Leu Val Ile  Ser His Glu 
    1205                 1210                 1215             


Glu Glu  Leu Ile Pro Leu His  Lys Ser Ile Pro Ser  Asp Pro Glu 
    1220                 1225                 1230             


Glu Arg  Lys Gln Tyr Thr Ile  Pro Cys His Thr Lys  Ala Ala His 
    1235                 1240                 1245             


Phe Asp  Ile Asp Trp Gly Lys  Glu Asp Asp Ser Asn  Leu Leu Ile 
    1250                 1255                 1260             


Gly Ile  Tyr Glu Tyr Gly Tyr  Gly Ser Trp Glu Met  Ile Lys Met 
    1265                 1270                 1275             


Asp Pro  Asp Leu Ser Leu Thr  His Lys Ile Leu Pro  Asp Asp Pro 
    1280                 1285                 1290             


Asp Lys  Lys Pro Gln Ala Lys  Gln Leu Gln Thr Arg  Ala Asp Tyr 
    1295                 1300                 1305             


Leu Ile  Lys Leu Leu Ser Arg  Asp Leu Ala Lys Lys  Glu Ala Leu 
    1310                 1315                 1320             


Ser Gly  Ala Gly Ser Ser Lys  Arg Arg Lys Ala Arg  Ala Lys Lys 
    1325                 1330                 1335             


Asn Lys  Ala Met Lys Ser Ile  Lys Val Lys Glu Glu  Ile Lys Ser 
    1340                 1345                 1350             


Asp Ser  Ser Pro Leu Pro Ser  Glu Lys Ser Asp Glu  Asp Asp Asp 
    1355                 1360                 1365             


Lys Asp  Glu Ile Ser Ser Val  Lys His Pro Asn Lys  Lys Ile Lys 
    1370                 1375                 1380             


Thr Glu  Arg Asp Ser Glu Glu  Lys Pro Glu Pro Asp  Val Tyr Ile 
    1385                 1390                 1395             


Lys Lys  Glu Pro Glu Glu Lys  Arg Glu Ala Lys Glu  Lys Glu Asn 
    1400                 1405                 1410             


Lys Lys  Glu Leu Lys Arg Glu  Ile Lys Glu Lys Glu  Asp Lys Lys 
    1415                 1420                 1425             


Asp Ile  Lys Glu Lys Asp Phe  Lys Glu Lys Arg Glu  Asn Lys Val 
    1430                 1435                 1440             


Lys Glu  Ala Ile Gln Lys Glu  Lys Asp Ile Lys Glu  Glu Lys Leu 
    1445                 1450                 1455             


Ser Glu  Ser Lys Ser Asp Gly  Arg Glu Arg Ser Lys  Lys Ser Ser 
    1460                 1465                 1470             


Val Ser  Asp Ala Pro Val His  Ile Thr Ala Ser Gly  Glu Pro Val 
    1475                 1480                 1485             


Pro Ile  Ser Glu Glu Ser Glu  Glu Leu Asp Gln Lys  Thr Phe Ser 
    1490                 1495                 1500             


Ile Cys  Lys Glu Arg Met Arg  Pro Val Lys Ala Ala  Leu Lys Gln 
    1505                 1510                 1515             


Leu Asp  Arg Pro Glu Lys Gly  Leu Ser Glu Arg Glu  Gln Leu Glu 
    1520                 1525                 1530             


His Thr  Arg Gln Cys Leu Ile  Lys Ile Gly Asp His  Ile Thr Glu 
    1535                 1540                 1545             


Cys Leu  Lys Glu Tyr Thr Asn  Pro Glu Gln Ile Lys  Gln Trp Arg 
    1550                 1555                 1560             


Lys Asn  Leu Trp Ile Phe Val  Ser Lys Phe Thr Glu  Phe Asp Ala 
    1565                 1570                 1575             


Arg Lys  Leu His Lys Leu Tyr  Lys His Ala Ile Lys  Lys Arg Gln 
    1580                 1585                 1590             


Glu Ser  Gln Gln Asn Ser Asp  Gln Asn Ser Asn Leu  Asn Pro His 
    1595                 1600                 1605             


Val Ile  Arg Asn Pro Asp Val  Glu Arg Leu Lys Glu  Asn Thr Asn 
    1610                 1615                 1620             


His Asp  Asp Ser Ser Arg Asp  Ser Tyr Ser Ser Asp  Arg His Leu 
    1625                 1630                 1635             


Thr Gln  Tyr His Asp His His  Lys Asp Arg His Gln  Gly Asp Ser 
    1640                 1645                 1650             


Tyr Lys  Lys Ser Asp Ser Arg  Lys Arg Pro Tyr Ser  Ser Phe Ser 
    1655                 1660                 1665             


Asn Gly  Lys Asp His Arg Asp  Trp Asp His Tyr Lys  Gln Asp Ser 
    1670                 1675                 1680             


Arg Tyr  Tyr Ser Asp Arg Glu  Lys His Arg Lys Leu  Asp Asp His 
    1685                 1690                 1695             


Arg Ser  Arg Asp His Arg Ser  Asn Leu Glu Gly Ser  Leu Lys Asp 
    1700                 1705                 1710             


Arg Ser  His Ser Asp His Arg  Ser His Ser Asp His  Arg Leu His 
    1715                 1720                 1725             


Ser Asp  His Arg Ser Ser Ser  Glu Tyr Thr His His  Lys Ser Ser 
    1730                 1735                 1740             


Arg Asp  Tyr Arg Tyr His Ser  Asp Trp Gln Met Asp  His Arg Ala 
    1745                 1750                 1755             


Ser Ser  Ser Gly Pro Arg Ser  Pro Leu Asp Gln Arg  Ser Pro Tyr 
    1760                 1765                 1770             


Gly Ser  Arg Ser Pro Phe Glu  His Ser Val Glu His  Lys Ser Thr 
    1775                 1780                 1785             


Pro Glu  His Thr Trp Ser Ser  Arg Lys Thr 
    1790                 1795             


<210>  2112
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHD2__Homo_sapiens__NP_001036037

<400>  2112

Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp 
            20                  25                  30          


Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly 
        35                  40                  45              


His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser 
    50                  55                  60                  


Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val 
                85                  90                  95      


Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser 
            100                 105                 110         


Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala 
        115                 120                 125             


Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln 
    130                 135                 140                 


Leu Lys Lys Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln 
145                 150                 155                 160 


Glu Gln Gly Thr Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys 
                165                 170                 175     


Ala Arg Arg Pro Val Pro Arg Arg Thr Val Pro Lys Pro Arg Val Lys 
            180                 185                 190         


Lys Gln Pro Lys Thr Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser 
        195                 200                 205             


Asp Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Thr Arg Arg 
    210                 215                 220                 


Arg Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Thr 
225                 230                 235                 240 


Asp Ser Asp Asp Leu Ile Glu Met Thr Gly Glu Gly Val Asp Glu Gln 
                245                 250                 255     


Gln Asp Asn Ser Glu Thr Ile Glu Lys Val Leu Asp Ser Arg Leu Gly 
            260                 265                 270         


Lys Lys Gly Ala Thr Gly Ala Ser Thr Thr Val Tyr Ala Ile Glu Ala 
        275                 280                 285             


Asn Gly Asp Pro Ser Gly Asp Phe Asp Thr Glu Lys Asp Glu Gly Glu 
    290                 295                 300                 


Ile Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Thr 
305                 310                 315                 320 


Trp Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys 
                325                 330                 335     


Lys Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu 
            340                 345                 350         


Gly Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu 
        355                 360                 365             


Leu Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile 
    370                 375                 380                 


Ala Val Lys Thr Ser Lys Ser Thr Leu Gly Gln Thr Asp Phe Pro Ala 
385                 390                 395                 400 


His Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys 
                405                 410                 415     


Trp Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu 
            420                 425                 430         


Ile Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn 
        435                 440                 445             


Asn Ser Lys Thr Ile Pro Thr Arg Glu Cys Lys Ala Leu Lys Gln Arg 
    450                 455                 460                 


Pro Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu 
465                 470                 475                 480 


Asn Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala 
                485                 490                 495     


His Ser Trp Cys Lys 
            500     


<210>  2113
<211>  2059
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHD3__Homo_sapiens__NP_001005271

<400>  2113

Met Ala Ser Pro Leu Arg Asp Glu Glu Glu Glu Glu Glu Glu Met Val 
1               5                   10                  15      


Val Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Asp Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Val Glu Ala Ala Asp Glu Asp Asp Glu Glu Asp Asp Asp 
        35                  40                  45              


Glu Gly Val Leu Gly Arg Gly Pro Gly His Asp Arg Gly Arg Asp Arg 
    50                  55                  60                  


His Ser Pro Pro Gly Cys His Leu Phe Pro Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Asp Lys Asp Asp 
                85                  90                  95      


Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys Lys Arg Lys Arg Gly 
            100                 105                 110         


Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys Pro Arg Lys Arg Lys 
        115                 120                 125             


Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu Arg Asp Glu Tyr Arg 
    130                 135                 140                 


Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly Thr Gly Pro Gly Arg 
145                 150                 155                 160 


Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu Lys Lys Thr Lys Arg 
                165                 170                 175     


Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys Gln Val Glu Gln Lys 
            180                 185                 190         


Ser Ser Ala Thr Leu Leu Leu Thr Trp Gly Leu Glu Asp Val Glu His 
        195                 200                 205             


Val Phe Ser Glu Glu Asp Tyr His Thr Leu Thr Asn Tyr Lys Ala Phe 
    210                 215                 220                 


Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys Asn Pro Lys Ile Pro 
225                 230                 235                 240 


Met Ser Lys Met Met Thr Ile Leu Gly Ala Lys Trp Arg Glu Phe Ser 
                245                 250                 255     


Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala Val Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val Ser Ala Ala Val Ser 
        275                 280                 285             


Ser Ala Thr Pro Ile Ala Pro Ser Gly Pro Pro Ala Leu Pro Pro Pro 
    290                 295                 300                 


Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg Arg Ala Lys Thr Lys 
305                 310                 315                 320 


Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser Lys Ser Pro Arg Val 
                325                 330                 335     


Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys Met Ala Pro Leu Lys 
            340                 345                 350         


Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys Lys Gly Gly Ser Tyr 
        355                 360                 365             


Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu Ala Glu Glu Ser Asp 
    370                 375                 380                 


Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly Arg Pro Asp Gly Pro 
385                 390                 395                 400 


Val Arg Thr Lys Lys Leu Lys Arg Gly Arg Pro Gly Arg Lys Lys Lys 
                405                 410                 415     


Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu Glu Glu Val Asp Gly 
            420                 425                 430         


Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly 
        435                 440                 445             


Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala Tyr His Leu Val Cys 
    450                 455                 460                 


Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly Lys Trp Ser Cys Pro 
465                 470                 475                 480 


His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala Lys Glu Glu Glu Glu 
                485                 490                 495     


Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu Lys Glu Glu Glu Asp 
            500                 505                 510         


Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu 
        515                 520                 525             


Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile His Cys Leu Asn Pro 
    530                 535                 540                 


Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr 
545                 550                 555                 560 


Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile Leu His Trp Arg Trp 
                565                 570                 575     


Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln Gln Ala Asp Gly Asn 
            580                 585                 590         


Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly Arg Ser Glu Arg Glu 
        595                 600                 605             


Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp His Cys Ser Trp Ala 
    610                 615                 620                 


Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val Met Tyr Arg Asn Tyr 
625                 630                 635                 640 


Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro Leu Asp Tyr Gly Ser 
                645                 650                 655     


Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys Val Lys Asp Pro His 
            660                 665                 670         


Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe Gly Ile Lys Pro Glu 
        675                 680                 685             


Trp Met Thr Val His Arg Ile Ile Asn His Ser Val Asp Lys Lys Gly 
    690                 695                 700                 


Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu Pro Tyr Asp Gln Ser 
705                 710                 715                 720 


Thr Trp Glu Glu Asp Glu Met Asn Ile Pro Glu Tyr Glu Glu His Lys 
                725                 730                 735     


Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met Gly Glu Asp Pro Ala 
            740                 745                 750         


Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu Leu Gln Gly Asp Gly 
        755                 760                 765             


Pro Pro Ser Ser Pro Thr Asn Asp Pro Thr Val Lys Tyr Glu Thr Gln 
    770                 775                 780                 


Pro Arg Phe Ile Thr Ala Thr Gly Gly Thr Leu His Met Tyr Gln Leu 
785                 790                 795                 800 


Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp Thr 
                805                 810                 815     


Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Thr Ile Val 
            820                 825                 830         


Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Thr Lys Gly Pro Phe Leu 
        835                 840                 845             


Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe Gln 
    850                 855                 860                 


Met Trp Ala Pro Lys Phe Tyr Val Val Thr Tyr Thr Gly Asp Lys Asp 
865                 870                 875                 880 


Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn Ala 
                885                 890                 895     


Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys Arg Glu Ala Gln Val 
            900                 905                 910         


Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp Gln 
        915                 920                 925             


Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu Val Val Asp Glu Ala 
    930                 935                 940                 


His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn Gly 
945                 950                 955                 960 


Tyr Lys Ile Asp His Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln Asn 
                965                 970                 975     


Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Thr Pro Glu Arg 
            980                 985                 990         


Phe Asn Asn Leu Glu Gly Phe Leu  Glu Glu Phe Ala Asp  Ile Ser Lys 
        995                 1000                 1005             


Glu Asp  Gln Ile Lys Lys Leu  His Asp Leu Leu Gly  Pro His Met 
    1010                 1015                 1020             


Leu Arg  Arg Leu Lys Ala Asp  Val Phe Lys Asn Met  Pro Ala Lys 
    1025                 1030                 1035             


Thr Glu  Leu Ile Val Arg Val  Glu Leu Ser Pro Met  Gln Lys Lys 
    1040                 1045                 1050             


Tyr Tyr  Lys Tyr Ile Leu Thr  Arg Asn Phe Glu Ala  Leu Asn Ser 
    1055                 1060                 1065             


Arg Gly  Gly Gly Asn Gln Val  Ser Leu Leu Asn Ile  Met Met Asp 
    1070                 1075                 1080             


Leu Lys  Lys Cys Cys Asn His  Pro Tyr Leu Phe Pro  Val Ala Ala 
    1085                 1090                 1095             


Met Glu  Ser Pro Lys Leu Pro  Ser Gly Ala Tyr Glu  Gly Gly Ala 
    1100                 1105                 1110             


Leu Ile  Lys Ser Ser Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu 
    1115                 1120                 1125             


Arg Lys  Leu Lys Glu Gln Gly  His Arg Val Leu Ile  Phe Ser Gln 
    1130                 1135                 1140             


Met Thr  Lys Met Leu Asp Leu  Leu Glu Asp Phe Leu  Asp Tyr Glu 
    1145                 1150                 1155             


Gly Tyr  Lys Tyr Glu Arg Ile  Asp Gly Gly Ile Thr  Gly Ala Leu 
    1160                 1165                 1170             


Arg Gln  Glu Ala Ile Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln 
    1175                 1180                 1185             


Phe Cys  Phe Leu Leu Ser Thr  Arg Ala Gly Gly Leu  Gly Ile Asn 
    1190                 1195                 1200             


Leu Ala  Thr Ala Asp Thr Val  Ile Ile Phe Asp Ser  Asp Trp Asn 
    1205                 1210                 1215             


Pro His  Asn Asp Ile Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly 
    1220                 1225                 1230             


Gln Ala  Asn Lys Val Met Ile  Tyr Arg Phe Val Thr  Arg Ala Ser 
    1235                 1240                 1245             


Val Glu  Glu Arg Ile Thr Gln  Val Ala Lys Arg Lys  Met Met Leu 
    1250                 1255                 1260             


Thr His  Leu Val Val Arg Pro  Gly Leu Gly Ser Lys  Ala Gly Ser 
    1265                 1270                 1275             


Met Ser  Lys Gln Glu Leu Asp  Asp Ile Leu Lys Phe  Gly Thr Glu 
    1280                 1285                 1290             


Glu Leu  Phe Lys Asp Glu Asn  Glu Gly Glu Asn Lys  Glu Glu Asp 
    1295                 1300                 1305             


Ser Ser  Val Ile His Tyr Asp  Asn Glu Ala Ile Ala  Arg Leu Leu 
    1310                 1315                 1320             


Asp Arg  Asn Gln Asp Ala Thr  Glu Asp Thr Asp Val  Gln Asn Met 
    1325                 1330                 1335             


Asn Glu  Tyr Leu Ser Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg 
    1340                 1345                 1350             


Glu Glu  Asp Lys Ile Glu Glu  Ile Glu Arg Glu Ile  Ile Lys Gln 
    1355                 1360                 1365             


Glu Glu  Asn Val Asp Pro Asp  Tyr Trp Glu Lys Leu  Leu Arg His 
    1370                 1375                 1380             


His Tyr  Glu Gln Gln Gln Glu  Asp Leu Ala Arg Asn  Leu Gly Lys 
    1385                 1390                 1395             


Gly Lys  Arg Val Arg Lys Gln  Val Asn Tyr Asn Asp  Ala Ala Gln 
    1400                 1405                 1410             


Glu Asp  Gln Asp Asn Gln Ser  Glu Tyr Ser Val Gly  Ser Glu Glu 
    1415                 1420                 1425             


Glu Asp  Glu Asp Phe Asp Glu  Arg Pro Glu Gly Arg  Arg Gln Ser 
    1430                 1435                 1440             


Lys Arg  Gln Leu Arg Asn Glu  Lys Asp Lys Pro Leu  Pro Pro Leu 
    1445                 1450                 1455             


Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val Leu Gly  Phe Asn Thr 
    1460                 1465                 1470             


Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Val Met Arg  Trp Gly Met 
    1475                 1480                 1485             


Pro Pro  Gln Asp Ala Phe Thr  Thr Gln Trp Leu Val  Arg Asp Leu 
    1490                 1495                 1500             


Arg Gly  Lys Thr Glu Lys Glu  Phe Lys Ala Tyr Val  Ser Leu Phe 
    1505                 1510                 1515             


Met Arg  His Leu Cys Glu Pro  Gly Ala Asp Gly Ser  Glu Thr Phe 
    1520                 1525                 1530             


Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser Arg Gln  Gln Val Leu 
    1535                 1540                 1545             


Thr Arg  Ile Gly Val Met Ser  Leu Val Lys Lys Lys  Val Gln Glu 
    1550                 1555                 1560             


Phe Glu  His Ile Asn Gly Arg  Trp Ser Met Pro Glu  Leu Met Pro 
    1565                 1570                 1575             


Asp Pro  Ser Ala Asp Ser Lys  Arg Ser Ser Arg Ala  Ser Ser Pro 
    1580                 1585                 1590             


Thr Lys  Thr Ser Pro Thr Thr  Pro Glu Ala Ser Ala  Thr Asn Ser 
    1595                 1600                 1605             


Pro Cys  Thr Ser Lys Pro Ala  Thr Pro Ala Pro Ser  Glu Lys Gly 
    1610                 1615                 1620             


Glu Gly  Ile Arg Thr Pro Leu  Glu Lys Glu Glu Ala  Glu Asn Gln 
    1625                 1630                 1635             


Glu Glu  Lys Pro Glu Lys Asn  Ser Arg Ile Gly Glu  Lys Met Glu 
    1640                 1645                 1650             


Thr Glu  Ala Asp Ala Pro Ser  Pro Ala Pro Ser Leu  Gly Glu Arg 
    1655                 1660                 1665             


Leu Glu  Pro Arg Lys Ile Pro  Leu Glu Asp Glu Val  Pro Gly Val 
    1670                 1675                 1680             


Pro Gly  Glu Met Glu Pro Glu  Pro Gly Tyr Arg Gly  Asp Arg Glu 
    1685                 1690                 1695             


Lys Ser  Ala Thr Glu Ser Thr  Pro Gly Glu Arg Gly  Glu Glu Lys 
    1700                 1705                 1710             


Pro Leu  Asp Gly Gln Glu His  Arg Glu Arg Pro Glu  Gly Glu Thr 
    1715                 1720                 1725             


Gly Asp  Leu Gly Lys Arg Glu  Asp Val Lys Gly Asp  Arg Glu Leu 
    1730                 1735                 1740             


Arg Pro  Gly Pro Arg Asp Glu  Pro Arg Ser Asn Gly  Arg Arg Glu 
    1745                 1750                 1755             


Glu Lys  Thr Glu Lys Pro Arg  Phe Met Phe Asn Ile  Ala Asp Gly 
    1760                 1765                 1770             


Gly Phe  Thr Glu Leu His Thr  Leu Trp Gln Asn Glu  Glu Arg Ala 
    1775                 1780                 1785             


Ala Ile  Ser Ser Gly Lys Leu  Asn Glu Ile Trp His  Arg Arg His 
    1790                 1795                 1800             


Asp Tyr  Trp Leu Leu Ala Gly  Ile Val Leu His Gly  Tyr Ala Arg 
    1805                 1810                 1815             


Trp Gln  Asp Ile Gln Asn Asp  Ala Gln Phe Ala Ile  Ile Asn Glu 
    1820                 1825                 1830             


Pro Phe  Lys Thr Glu Ala Asn  Lys Gly Asn Phe Leu  Glu Met Lys 
    1835                 1840                 1845             


Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu Leu Glu  Gln Ala Leu 
    1850                 1855                 1860             


Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala Tyr Leu  Asn Leu Ser 
    1865                 1870                 1875             


Gln Glu  Pro Ala His Pro Ala  Met Ala Leu His Ala  Arg Phe Ala 
    1880                 1885                 1890             


Glu Ala  Glu Cys Leu Ala Glu  Ser His Gln His Leu  Ser Lys Glu 
    1895                 1900                 1905             


Ser Leu  Ala Gly Asn Lys Pro  Ala Asn Ala Val Leu  His Lys Val 
    1910                 1915                 1920             


Leu Asn  Gln Leu Glu Glu Leu  Leu Ser Asp Met Lys  Ala Asp Val 
    1925                 1930                 1935             


Thr Arg  Leu Pro Ala Thr Leu  Ser Arg Ile Pro Pro  Ile Ala Ala 
    1940                 1945                 1950             


Arg Leu  Gln Met Ser Glu Arg  Ser Ile Leu Ser Arg  Leu Ala Ser 
    1955                 1960                 1965             


Lys Gly  Thr Glu Pro His Pro  Thr Pro Ala Tyr Pro  Pro Gly Pro 
    1970                 1975                 1980             


Tyr Ala  Thr Pro Pro Gly Tyr  Gly Ala Ala Phe Ser  Ala Ala Pro 
    1985                 1990                 1995             


Val Gly  Ala Leu Ala Ala Ala  Gly Ala Asn Tyr Ser  Gln Met Pro 
    2000                 2005                 2010             


Ala Gly  Ser Phe Ile Thr Ala  Ala Thr Asn Gly Pro  Pro Val Leu 
    2015                 2020                 2025             


Val Lys  Lys Glu Lys Glu Met  Val Gly Ala Leu Val  Ser Asp Gly 
    2030                 2035                 2040             


Leu Asp  Arg Lys Glu Pro Arg  Ala Gly Glu Val Ile  Cys Ile Asp 
    2045                 2050                 2055             


Asp 
    


<210>  2114
<211>  1905
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHD4__Homo_sapiens__NP_001284482

<400>  2114

Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Thr Glu Thr 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Leu Gly Asp Ser Ser Gly 
65                  70                  75                  80  


Glu Gly Pro Glu Phe Val Glu Glu Glu Glu Glu Val Ala Leu Arg Ser 
                85                  90                  95      


Asp Ser Glu Gly Ser Asp Tyr Thr Pro Gly Lys Lys Lys Lys Lys Lys 
            100                 105                 110         


Leu Gly Pro Lys Lys Glu Lys Lys Ser Lys Ser Lys Arg Lys Glu Glu 
        115                 120                 125             


Glu Glu Glu Glu Asp Asp Asp Asp Asp Ser Lys Glu Pro Lys Ser Ser 
    130                 135                 140                 


Ala Gln Leu Leu Glu Asp Trp Gly Met Glu Asp Ile Asp His Val Phe 
145                 150                 155                 160 


Ser Glu Glu Asp Tyr Arg Thr Leu Thr Asn Tyr Lys Ala Phe Ser Gln 
                165                 170                 175     


Phe Val Arg Pro Leu Ile Ala Ala Lys Asn Pro Lys Ile Ala Val Ser 
            180                 185                 190         


Lys Met Met Met Val Leu Gly Ala Lys Trp Arg Glu Phe Ser Thr Asn 
        195                 200                 205             


Asn Pro Phe Lys Gly Ser Ser Gly Ala Ser Val Ala Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Val Ala Val Val Glu Ser Met Val Thr Ala Thr Glu Val Ala 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Val Glu Val Pro Ile Arg Lys Ala Lys Thr Lys 
                245                 250                 255     


Glu Gly Lys Gly Pro Asn Ala Arg Arg Lys Pro Lys Gly Ser Pro Arg 
            260                 265                 270         


Val Pro Asp Ala Lys Lys Pro Lys Pro Lys Lys Val Ala Pro Leu Lys 
        275                 280                 285             


Ile Lys Leu Gly Gly Phe Gly Ser Lys Arg Lys Arg Ser Ser Ser Glu 
    290                 295                 300                 


Asp Asp Asp Leu Asp Val Glu Ser Asp Phe Asp Asp Ala Ser Ile Asn 
305                 310                 315                 320 


Ser Tyr Ser Val Ser Asp Gly Ser Thr Ser Arg Ser Ser Arg Ser Arg 
                325                 330                 335     


Lys Lys Leu Arg Thr Thr Lys Lys Lys Lys Lys Gly Glu Glu Glu Val 
            340                 345                 350         


Thr Ala Val Asp Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val 
        355                 360                 365             


Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala 
    370                 375                 380                 


Tyr His Met Val Cys Leu Asp Pro Asp Met Glu Lys Ala Pro Glu Gly 
385                 390                 395                 400 


Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Ala 
                405                 410                 415     


Lys Glu Asp Asn Ser Glu Gly Glu Glu Ile Leu Glu Glu Val Gly Gly 
            420                 425                 430         


Asp Leu Glu Glu Glu Asp Asp His His Met Glu Phe Cys Arg Val Cys 
        435                 440                 445             


Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp Thr Cys Pro Ser Ser Tyr 
    450                 455                 460                 


His Ile His Cys Leu Asn Pro Pro Leu Pro Glu Ile Pro Asn Gly Glu 
465                 470                 475                 480 


Trp Leu Cys Pro Arg Cys Thr Cys Pro Ala Leu Lys Gly Lys Val Gln 
                485                 490                 495     


Lys Ile Leu Ile Trp Lys Trp Gly Gln Pro Pro Ser Pro Thr Pro Val 
            500                 505                 510         


Pro Arg Pro Pro Asp Ala Asp Pro Asn Thr Pro Ser Pro Lys Pro Leu 
        515                 520                 525             


Glu Gly Arg Pro Glu Arg Gln Phe Phe Val Lys Trp Gln Gly Met Ser 
    530                 535                 540                 


Tyr Trp His Cys Ser Trp Val Ser Glu Leu Gln Leu Glu Leu His Cys 
545                 550                 555                 560 


Gln Val Met Phe Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro 
                565                 570                 575     


Pro Ser Gly Asp Phe Gly Gly Asp Glu Glu Lys Ser Arg Lys Arg Lys 
            580                 585                 590         


Asn Lys Asp Pro Lys Phe Ala Glu Met Glu Glu Arg Phe Tyr Arg Tyr 
        595                 600                 605             


Gly Ile Lys Pro Glu Trp Met Met Ile His Arg Ile Leu Asn His Ser 
    610                 615                 620                 


Val Asp Lys Lys Gly His Val His Tyr Leu Ile Lys Trp Arg Asp Leu 
625                 630                 635                 640 


Pro Tyr Asp Gln Ala Ser Trp Glu Ser Glu Asp Val Glu Ile Gln Asp 
                645                 650                 655     


Tyr Asp Leu Phe Lys Gln Ser Tyr Trp Asn His Arg Glu Leu Met Arg 
            660                 665                 670         


Gly Glu Glu Gly Arg Pro Gly Lys Lys Leu Lys Lys Val Lys Leu Arg 
        675                 680                 685             


Lys Leu Glu Arg Pro Pro Glu Thr Pro Thr Val Asp Pro Thr Val Lys 
    690                 695                 700                 


Tyr Glu Arg Gln Pro Glu Tyr Leu Asp Ala Thr Gly Gly Thr Leu His 
705                 710                 715                 720 


Pro Tyr Gln Met Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln 
                725                 730                 735     


Gly Thr Asp Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val 
            740                 745                 750         


Gln Thr Ala Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys 
        755                 760                 765             


Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp Glu 
    770                 775                 780                 


Arg Glu Phe Glu Met Trp Ala Pro Asp Met Tyr Val Val Thr Tyr Val 
785                 790                 795                 800 


Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser Phe 
                805                 810                 815     


Glu Asp Asn Ala Ile Arg Gly Gly Lys Lys Ala Ser Arg Met Lys Lys 
            820                 825                 830         


Glu Ala Ser Val Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu Ile 
        835                 840                 845             


Thr Ile Asp Met Ala Ile Leu Gly Ser Ile Asp Trp Ala Cys Leu Ile 
    850                 855                 860                 


Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg 
865                 870                 875                 880 


Val Leu Asn Gly Tyr Ser Leu Gln His Lys Leu Leu Leu Thr Gly Thr 
                885                 890                 895     


Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu 
            900                 905                 910         


Thr Pro Glu Arg Phe His Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala 
        915                 920                 925             


Asp Ile Ala Lys Glu Asp Gln Ile Lys Lys Leu His Asp Met Leu Gly 
    930                 935                 940                 


Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro 
945                 950                 955                 960 


Ser Lys Thr Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln Lys 
                965                 970                 975     


Lys Tyr Tyr Lys Tyr Ile Leu Thr Arg Asn Phe Glu Ala Leu Asn Ala 
            980                 985                 990         


Arg Gly Gly Gly Asn Gln Val Ser  Leu Leu Asn Val Val  Met Asp Leu 
        995                 1000                 1005             


Lys Lys  Cys Cys Asn His Pro  Tyr Leu Phe Pro Val  Ala Ala Met 
    1010                 1015                 1020             


Glu Ala  Pro Lys Met Pro Asn  Gly Met Tyr Asp Gly  Ser Ala Leu 
    1025                 1030                 1035             


Ile Arg  Ala Ser Gly Lys Leu  Leu Leu Leu Gln Lys  Met Leu Lys 
    1040                 1045                 1050             


Asn Leu  Lys Glu Gly Gly His  Arg Val Leu Ile Phe  Ser Gln Met 
    1055                 1060                 1065             


Thr Lys  Met Leu Asp Leu Leu  Glu Asp Phe Leu Glu  His Glu Gly 
    1070                 1075                 1080             


Tyr Lys  Tyr Glu Arg Ile Asp  Gly Gly Ile Thr Gly  Asn Met Arg 
    1085                 1090                 1095             


Gln Glu  Ala Ile Asp Arg Phe  Asn Ala Pro Gly Ala  Gln Gln Phe 
    1100                 1105                 1110             


Cys Phe  Leu Leu Ser Thr Arg  Ala Gly Gly Leu Gly  Ile Asn Leu 
    1115                 1120                 1125             


Ala Thr  Ala Asp Thr Val Ile  Ile Tyr Asp Ser Asp  Trp Asn Pro 
    1130                 1135                 1140             


His Asn  Asp Ile Gln Ala Phe  Ser Arg Ala His Arg  Ile Gly Gln 
    1145                 1150                 1155             


Asn Lys  Lys Val Met Ile Tyr  Arg Phe Val Thr Arg  Ala Ser Val 
    1160                 1165                 1170             


Glu Glu  Arg Ile Thr Gln Val  Ala Lys Lys Lys Met  Met Leu Thr 
    1175                 1180                 1185             


His Leu  Val Val Arg Pro Gly  Leu Gly Ser Lys Thr  Gly Ser Met 
    1190                 1195                 1200             


Ser Lys  Gln Glu Leu Asp Asp  Ile Leu Lys Phe Gly  Thr Glu Glu 
    1205                 1210                 1215             


Leu Phe  Lys Asp Glu Ala Thr  Asp Gly Gly Gly Asp  Asn Lys Glu 
    1220                 1225                 1230             


Gly Glu  Asp Ser Ser Val Ile  His Tyr Asp Asp Lys  Ala Ile Glu 
    1235                 1240                 1245             


Arg Leu  Leu Asp Arg Asn Gln  Asp Glu Thr Glu Asp  Thr Glu Leu 
    1250                 1255                 1260             


Gln Gly  Met Asn Glu Tyr Leu  Ser Ser Phe Lys Val  Ala Gln Tyr 
    1265                 1270                 1275             


Val Val  Arg Glu Glu Glu Met  Gly Glu Glu Glu Glu  Val Glu Arg 
    1280                 1285                 1290             


Glu Ile  Ile Lys Gln Glu Glu  Ser Val Asp Pro Asp  Tyr Trp Glu 
    1295                 1300                 1305             


Lys Leu  Leu Arg His His Tyr  Glu Gln Gln Gln Glu  Asp Leu Ala 
    1310                 1315                 1320             


Arg Asn  Leu Gly Lys Gly Lys  Arg Ile Arg Lys Gln  Val Asn Tyr 
    1325                 1330                 1335             


Asn Asp  Gly Ser Gln Glu Asp  Arg Asp Trp Gln Asp  Asp Gln Ser 
    1340                 1345                 1350             


Asp Asn  Gln Ser Asp Tyr Ser  Val Ala Ser Glu Glu  Gly Asp Glu 
    1355                 1360                 1365             


Asp Phe  Asp Glu Arg Ser Glu  Ala Pro Arg Arg Pro  Ser Arg Lys 
    1370                 1375                 1380             


Gly Leu  Arg Asn Asp Lys Asp  Lys Pro Leu Pro Pro  Leu Leu Ala 
    1385                 1390                 1395             


Arg Val  Gly Gly Asn Ile Glu  Val Leu Gly Phe Asn  Ala Arg Gln 
    1400                 1405                 1410             


Arg Lys  Ala Phe Leu Asn Ala  Ile Met Arg Tyr Gly  Met Pro Pro 
    1415                 1420                 1425             


Gln Asp  Ala Phe Thr Thr Gln  Trp Leu Val Arg Asp  Leu Arg Gly 
    1430                 1435                 1440             


Lys Ser  Glu Lys Glu Phe Lys  Ala Tyr Val Ser Leu  Phe Met Arg 
    1445                 1450                 1455             


His Leu  Cys Glu Pro Gly Ala  Asp Gly Ala Glu Thr  Phe Ala Asp 
    1460                 1465                 1470             


Gly Val  Pro Arg Glu Gly Leu  Ser Arg Gln His Val  Leu Thr Arg 
    1475                 1480                 1485             


Ile Gly  Val Met Ser Leu Ile  Arg Lys Lys Val Gln  Glu Phe Glu 
    1490                 1495                 1500             


His Val  Asn Gly Arg Trp Ser  Met Pro Glu Leu Ala  Glu Val Glu 
    1505                 1510                 1515             


Glu Asn  Lys Lys Met Ser Gln  Pro Gly Ser Pro Ser  Pro Lys Thr 
    1520                 1525                 1530             


Pro Thr  Pro Ser Thr Pro Gly  Asp Thr Gln Pro Asn  Thr Pro Ala 
    1535                 1540                 1545             


Pro Val  Pro Pro Ala Glu Asp  Gly Ile Lys Ile Glu  Glu Asn Ser 
    1550                 1555                 1560             


Leu Lys  Glu Glu Glu Ser Ile  Glu Gly Glu Lys Glu  Val Lys Ser 
    1565                 1570                 1575             


Thr Ala  Pro Glu Thr Ala Ile  Glu Cys Thr Gln Ala  Pro Ala Pro 
    1580                 1585                 1590             


Ala Ser  Glu Asp Glu Lys Val  Val Val Glu Pro Pro  Glu Gly Glu 
    1595                 1600                 1605             


Glu Lys  Val Glu Lys Ala Glu  Val Lys Glu Arg Thr  Glu Glu Pro 
    1610                 1615                 1620             


Met Glu  Thr Glu Pro Lys Gly  Ala Ala Asp Val Glu  Lys Val Glu 
    1625                 1630                 1635             


Glu Lys  Ser Ala Ile Asp Leu  Thr Pro Ile Val Val  Glu Asp Lys 
    1640                 1645                 1650             


Glu Glu  Lys Lys Glu Glu Glu  Glu Lys Lys Glu Val  Met Leu Gln 
    1655                 1660                 1665             


Asn Gly  Glu Thr Pro Lys Asp  Leu Asn Asp Glu Lys  Gln Lys Lys 
    1670                 1675                 1680             


Asn Ile  Lys Gln Arg Phe Met  Phe Asn Ile Ala Asp  Gly Gly Phe 
    1685                 1690                 1695             


Thr Glu  Leu His Ser Leu Trp  Gln Asn Glu Glu Arg  Ala Ala Thr 
    1700                 1705                 1710             


Val Thr  Lys Lys Thr Tyr Glu  Ile Trp His Arg Arg  His Asp Tyr 
    1715                 1720                 1725             


Trp Leu  Leu Ala Gly Ile Ile  Asn His Gly Tyr Ala  Arg Trp Gln 
    1730                 1735                 1740             


Asp Ile  Gln Asn Asp Pro Arg  Tyr Ala Ile Leu Asn  Glu Pro Phe 
    1745                 1750                 1755             


Lys Gly  Glu Met Asn Arg Gly  Asn Phe Leu Glu Ile  Lys Asn Lys 
    1760                 1765                 1770             


Phe Leu  Ala Arg Arg Phe Lys  Leu Leu Glu Gln Ala  Leu Val Ile 
    1775                 1780                 1785             


Glu Glu  Gln Leu Arg Arg Ala  Ala Tyr Leu Asn Met  Ser Glu Asp 
    1790                 1795                 1800             


Pro Ser  His Pro Ser Met Ala  Leu Asn Thr Arg Phe  Ala Glu Val 
    1805                 1810                 1815             


Glu Cys  Leu Ala Glu Ser His  Gln His Leu Ser Lys  Glu Ser Met 
    1820                 1825                 1830             


Ala Gly  Asn Lys Pro Ala Asn  Ala Val Leu His Lys  Val Leu Lys 
    1835                 1840                 1845             


Gln Leu  Glu Glu Leu Leu Ser  Asp Met Lys Ala Asp  Val Thr Arg 
    1850                 1855                 1860             


Leu Pro  Ala Thr Ile Ala Arg  Ile Pro Pro Val Ala  Val Arg Leu 
    1865                 1870                 1875             


Gln Met  Ser Glu Arg Asn Ile  Leu Ser Arg Leu Ala  Asn Arg Ala 
    1880                 1885                 1890             


Pro Glu  Pro Thr Pro Gln Gln  Val Ala Gln Gln Gln  
    1895                 1900                 1905 


<210>  2115
<211>  2715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHD6__Homo_sapiens__NP_115597

<400>  2115

Met Lys Met Lys Ile Gln Lys Lys Glu Lys Gln Leu Ser Asn Leu Lys 
1               5                   10                  15      


Val Leu Asn His Ser Pro Met Ser Asp Ala Ser Val Asn Phe Asp Tyr 
            20                  25                  30          


Lys Ser Pro Ser Pro Phe Asp Cys Ser Thr Asp Gln Glu Glu Lys Ile 
        35                  40                  45              


Glu Asp Val Ala Ser His Cys Leu Pro Gln Lys Asp Leu Tyr Thr Ala 
    50                  55                  60                  


Glu Glu Glu Ala Ala Thr Leu Phe Pro Arg Lys Met Thr Ser His Asn 
65                  70                  75                  80  


Gly Met Glu Asp Ser Gly Gly Gly Gly Thr Gly Val Lys Lys Lys Arg 
                85                  90                  95      


Lys Lys Lys Glu Pro Gly Asp Gln Glu Gly Ala Ala Lys Gly Ser Lys 
            100                 105                 110         


Asp Arg Glu Pro Lys Pro Lys Arg Lys Arg Glu Pro Lys Glu Pro Lys 
        115                 120                 125             


Glu Pro Arg Lys Ala Lys Glu Pro Lys Lys Ala Lys Glu His Lys Glu 
    130                 135                 140                 


Pro Lys Gln Lys Asp Gly Ala Lys Lys Ala Arg Lys Pro Arg Glu Ala 
145                 150                 155                 160 


Ser Gly Thr Lys Glu Ala Lys Glu Lys Arg Ser Cys Thr Asp Ser Ala 
                165                 170                 175     


Ala Arg Thr Lys Ser Arg Lys Ala Ser Lys Glu Gln Gly Pro Thr Pro 
            180                 185                 190         


Val Glu Lys Lys Lys Lys Gly Lys Arg Lys Ser Glu Thr Thr Val Glu 
        195                 200                 205             


Ser Leu Glu Leu Asp Gln Gly Leu Thr Asn Pro Ser Leu Arg Ser Pro 
    210                 215                 220                 


Glu Glu Ser Thr Glu Ser Thr Asp Ser Gln Lys Arg Arg Ser Gly Arg 
225                 230                 235                 240 


Gln Val Lys Arg Arg Lys Tyr Asn Glu Asp Leu Asp Phe Lys Val Val 
                245                 250                 255     


Asp Asp Asp Gly Glu Thr Ile Ala Val Leu Gly Ala Gly Arg Thr Ser 
            260                 265                 270         


Ala Leu Ser Ala Ser Thr Leu Ala Trp Gln Ala Glu Glu Pro Pro Glu 
        275                 280                 285             


Asp Asp Ala Asn Ile Ile Glu Lys Ile Leu Ala Ser Lys Thr Val Gln 
    290                 295                 300                 


Glu Val His Pro Gly Glu Pro Pro Phe Asp Leu Glu Leu Phe Tyr Val 
305                 310                 315                 320 


Lys Tyr Arg Asn Phe Ser Tyr Leu His Cys Lys Trp Ala Thr Met Glu 
                325                 330                 335     


Glu Leu Glu Lys Asp Pro Arg Ile Ala Gln Lys Ile Lys Arg Phe Arg 
            340                 345                 350         


Asn Lys Gln Ala Gln Met Lys His Ile Phe Thr Glu Pro Asp Glu Asp 
        355                 360                 365             


Leu Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Glu Val Ala 
    370                 375                 380                 


His Thr Lys Asp Ala Glu Thr Gly Glu Glu Val Thr His Tyr Leu Val 
385                 390                 395                 400 


Lys Trp Cys Ser Leu Pro Tyr Glu Glu Ser Thr Trp Glu Leu Glu Glu 
                405                 410                 415     


Asp Val Asp Pro Ala Lys Val Lys Glu Phe Glu Ser Leu Gln Val Leu 
            420                 425                 430         


Pro Glu Ile Lys His Val Glu Arg Pro Ala Ser Asp Ser Trp Gln Lys 
        435                 440                 445             


Leu Glu Lys Ser Arg Glu Tyr Lys Asn Ser Asn Gln Leu Arg Glu Tyr 
    450                 455                 460                 


Gln Leu Glu Gly Met Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Lys 
465                 470                 475                 480 


Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ser 
                485                 490                 495     


Ile Thr Phe Leu Ser Glu Ile Phe Leu Arg Gly Ile His Gly Pro Phe 
            500                 505                 510         


Leu Ile Ile Ala Pro Leu Ser Thr Ile Thr Asn Trp Glu Arg Glu Phe 
        515                 520                 525             


Arg Thr Trp Thr Glu Met Asn Ala Ile Val Tyr His Gly Ser Gln Ile 
    530                 535                 540                 


Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Val Tyr Arg Asp Ala Gln 
545                 550                 555                 560 


Gly Asn Pro Leu Ser Gly Val Phe Lys Phe His Val Val Ile Thr Thr 
                565                 570                 575     


Phe Glu Met Ile Leu Ala Asp Cys Pro Glu Leu Lys Lys Ile His Trp 
            580                 585                 590         


Ser Cys Val Ile Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn Cys 
        595                 600                 605             


Lys Leu Leu Glu Gly Leu Lys Leu Met Ala Leu Glu His Lys Val Leu 
    610                 615                 620                 


Leu Thr Gly Thr Pro Leu Gln Asn Ser Val Glu Glu Leu Phe Ser Leu 
625                 630                 635                 640 


Leu Asn Phe Leu Glu Pro Ser Gln Phe Pro Ser Glu Thr Ala Phe Leu 
                645                 650                 655     


Glu Glu Phe Gly Asp Leu Lys Thr Glu Glu Gln Val Lys Lys Leu Gln 
            660                 665                 670         


Ser Ile Leu Lys Pro Met Met Leu Arg Arg Leu Lys Asp Asp Val Glu 
        675                 680                 685             


Lys Asn Leu Ala Pro Lys Gln Glu Thr Ile Ile Glu Val Glu Leu Thr 
    690                 695                 700                 


Asn Ile Gln Lys Lys Tyr Tyr Arg Ala Ile Leu Glu Lys Asn Phe Ser 
705                 710                 715                 720 


Phe Leu Thr Lys Gly Ala Asn Gln His Asn Met Pro Asn Leu Ile Asn 
                725                 730                 735     


Thr Met Met Glu Leu Arg Lys Cys Cys Asn His Pro Tyr Leu Ile Asn 
            740                 745                 750         


Gly Ala Glu Glu Lys Ile Leu Glu Asp Phe Arg Lys Thr His Ser Pro 
        755                 760                 765             


Asp Ala Pro Asp Phe Gln Leu Gln Ala Met Ile Gln Ala Ala Gly Lys 
    770                 775                 780                 


Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Leu Ile Ala Gly Gly His 
785                 790                 795                 800 


Lys Val Leu Ile Phe Ser Gln Met Val Arg Cys Leu Asp Ile Leu Glu 
                805                 810                 815     


Asp Tyr Leu Ile Gln Arg Arg Tyr Thr Tyr Glu Arg Ile Asp Gly Arg 
            820                 825                 830         


Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp Arg Phe Cys Lys Pro 
        835                 840                 845             


Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Thr Arg Ala Gly Gly Leu 
    850                 855                 860                 


Gly Ile Asn Leu Thr Ala Ala Asp Thr Cys Ile Ile Phe Asp Ser Asp 
865                 870                 875                 880 


Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala Arg Cys His Arg Ile 
                885                 890                 895     


Gly Gln Ser Lys Ala Val Lys Val Tyr Arg Leu Ile Thr Arg Asn Ser 
            900                 905                 910         


Tyr Glu Arg Glu Met Phe Asp Lys Ala Ser Leu Lys Leu Gly Leu Asp 
        915                 920                 925             


Lys Ala Val Leu Gln Asp Ile Asn Arg Lys Gly Gly Thr Asn Gly Val 
    930                 935                 940                 


Gln Gln Leu Ser Lys Met Glu Val Glu Asp Leu Leu Arg Lys Gly Ala 
945                 950                 955                 960 


Tyr Gly Ala Leu Met Asp Glu Glu Asp Glu Gly Ser Lys Phe Cys Glu 
                965                 970                 975     


Glu Asp Ile Asp Gln Ile Leu Gln Arg Arg Thr His Thr Ile Thr Ile 
            980                 985                 990         


Gln Ser Glu Gly Lys Gly Ser Thr  Phe Ala Lys Ala Ser  Phe Val Ala 
        995                 1000                 1005             


Ser Gly  Asn Arg Thr Asp Ile  Ser Leu Asp Asp Pro  Asn Phe Trp 
    1010                 1015                 1020             


Gln Lys  Trp Ala Lys Ile Ala  Glu Leu Asp Thr Glu  Ala Lys Asn 
    1025                 1030                 1035             


Glu Lys  Glu Ser Leu Val Ile  Asp Arg Pro Arg Val  Arg Lys Gln 
    1040                 1045                 1050             


Thr Lys  His Tyr Asn Ser Phe  Glu Glu Asp Glu Leu  Met Glu Phe 
    1055                 1060                 1065             


Ser Glu  Leu Asp Ser Asp Ser  Asp Glu Arg Pro Thr  Arg Ser Arg 
    1070                 1075                 1080             


Arg Leu  Asn Asp Lys Ala Arg  Arg Tyr Leu Arg Ala  Glu Cys Phe 
    1085                 1090                 1095             


Arg Val  Glu Lys Asn Leu Leu  Ile Phe Gly Trp Gly  Arg Trp Lys 
    1100                 1105                 1110             


Asp Ile  Leu Thr His Gly Arg  Phe Lys Trp His Leu  Asn Glu Lys 
    1115                 1120                 1125             


Asp Met  Glu Met Ile Cys Arg  Ala Leu Leu Val Tyr  Cys Val Lys 
    1130                 1135                 1140             


His Tyr  Lys Gly Asp Glu Lys  Ile Lys Ser Phe Ile  Trp Glu Leu 
    1145                 1150                 1155             


Ile Thr  Pro Thr Lys Asp Gly  Gln Ala Gln Thr Leu  Gln Asn His 
    1160                 1165                 1170             


Ser Gly  Leu Ser Ala Pro Val  Pro Arg Gly Arg Lys  Gly Lys Lys 
    1175                 1180                 1185             


Thr Lys  Asn Gln Leu Leu Ile  Pro Glu Leu Lys Asp  Ala Asp Trp 
    1190                 1195                 1200             


Leu Ala  Thr Cys Asn Pro Glu  Val Val Leu His Asp  Asp Gly Tyr 
    1205                 1210                 1215             


Lys Lys  His Leu Lys Gln His  Cys Asn Lys Val Leu  Leu Arg Val 
    1220                 1225                 1230             


Arg Met  Leu Tyr Tyr Leu Lys  Ala Glu Ile Leu Gly  Glu Ala Ala 
    1235                 1240                 1245             


Glu Lys  Ala Phe Glu Gly Ser  Pro Ala Arg Glu Leu  Asp Val Pro 
    1250                 1255                 1260             


Leu Pro  Asp Ile Asp Tyr Met  Glu Ile Pro Val Asp  Trp Trp Asp 
    1265                 1270                 1275             


Ala Glu  Ala Asp Lys Ser Leu  Leu Ile Gly Val Phe  Lys His Gly 
    1280                 1285                 1290             


Tyr Glu  Arg Tyr Asn Ala Met  Arg Ala Asp Pro Ala  Leu Cys Phe 
    1295                 1300                 1305             


Leu Glu  Lys Val Gly Met Pro  Asp Glu Lys Ser Leu  Ser Ala Glu 
    1310                 1315                 1320             


Gln Gly  Val Thr Asp Gly Thr  Ser Asp Ile Pro Glu  Arg Gly Asn 
    1325                 1330                 1335             


Thr Asp  Lys Glu Asp Asn Ala  Glu Asp Lys Val Asp  Gly Leu Gln 
    1340                 1345                 1350             


Lys Gln  Thr Glu Ser Ser Ser  Asp Gly Gly Asp Gly  Val Phe Ser 
    1355                 1360                 1365             


Glu Lys  Lys Asp Asp Ser Arg  Ala Ala Gln Asp Gly  Ser Asp Pro 
    1370                 1375                 1380             


Asp Lys  Ser Pro Trp Pro Val  Ser Ser Ala Leu Thr  Ala Arg Leu 
    1385                 1390                 1395             


Arg Arg  Leu Val Thr Val Tyr  Gln Arg Cys Asn Arg  Lys Glu Leu 
    1400                 1405                 1410             


Cys Arg  Pro Glu Ile Leu Gly  Pro Gly Asn Gln Gly  Tyr Trp Val 
    1415                 1420                 1425             


Gln Glu  Glu Met Phe Arg Arg  Thr Ser Glu Met Asp  Leu Ile Asn 
    1430                 1435                 1440             


Lys Glu  Ala Gln Lys Arg Trp  Thr Arg Arg Glu Gln  Ala Asp Phe 
    1445                 1450                 1455             


Tyr Arg  Thr Val Ser Ser Phe  Gly Val Val Tyr Asp  Gln Glu Lys 
    1460                 1465                 1470             


Lys Thr  Phe Asp Trp Thr Gln  Phe Arg Ile Ile Ser  Arg Leu Asp 
    1475                 1480                 1485             


Lys Lys  Ser Asp Glu Ser Leu  Glu Gln Tyr Phe Tyr  Ser Phe Val 
    1490                 1495                 1500             


Ala Met  Cys Arg Asn Val Cys  Arg Leu Pro Thr Trp  Lys Asp Gly 
    1505                 1510                 1515             


Gly Pro  Pro Asp Thr Thr Ile  Tyr Val Glu Pro Ile  Thr Glu Glu 
    1520                 1525                 1530             


Arg Ala  Ala Arg Thr Leu Tyr  Arg Ile Glu Leu Leu  Arg Lys Val 
    1535                 1540                 1545             


Arg Glu  Gln Val Leu Lys Cys  Pro Gln Leu His Glu  Arg Leu Gln 
    1550                 1555                 1560             


Leu Cys  Arg Pro Ser Leu Tyr  Leu Pro Val Trp Trp  Glu Cys Gly 
    1565                 1570                 1575             


Lys His  Asp Arg Asp Leu Leu  Ile Gly Thr Ala Lys  His Gly Leu 
    1580                 1585                 1590             


Asn Arg  Thr Asp Cys Tyr Ile  Met Asn Asp Pro Gln  Leu Ser Phe 
    1595                 1600                 1605             


Leu Asp  Ala Tyr Arg Asn Tyr  Ala Gln His Lys Arg  Ser Gly Thr 
    1610                 1615                 1620             


Gln Ala  Pro Gly Asn Leu Cys  Cys Leu Tyr Gln Thr  Asn Ser Lys 
    1625                 1630                 1635             


Leu Tyr  Glu Ser Leu Thr Tyr  Ser Gln Met Ser Arg  Thr Ser Glu 
    1640                 1645                 1650             


Ser Leu  Glu Asn Glu Pro Glu  Asn Leu Val Arg Val  Glu Ser Arg 
    1655                 1660                 1665             


Asp Asp  His Leu Ser Leu Pro  Asp Val Thr Cys Glu  Asn Phe Ile 
    1670                 1675                 1680             


Ser Lys  Val Gln Asp Val Ile  Ser Ile Asn His Asp  Glu Ser Leu 
    1685                 1690                 1695             


Leu Pro  Glu Ser Leu Glu Ser  Met Met Tyr Gly Lys  Lys Val Leu 
    1700                 1705                 1710             


Ser Gln  Glu Pro Ser Ser Phe  Gln Glu Ser Pro Ser  Thr Asn Thr 
    1715                 1720                 1725             


Glu Ser  Arg Lys Asp Val Ile  Thr Ile Ser Ile Ser  Lys Asp Gly 
    1730                 1735                 1740             


Asn Cys  Gln Ser Gly Gly Pro  Glu Ala Glu Ile Ala  Ser Gly Pro 
    1745                 1750                 1755             


Thr Phe  Met Gly Ser Leu Glu  Ala Gly Gly Val Ala  Gln Ala Asn 
    1760                 1765                 1770             


Ile Lys  Asn Gly Lys His Leu  Leu Met Ser Ile Ser  Lys Glu Gly 
    1775                 1780                 1785             


Glu Leu  Cys Cys Ser Glu Ala  Gly Gln Arg Pro Glu  Asn Ile Gly 
    1790                 1795                 1800             


Gln Leu  Glu Ala Lys Cys Leu  Ala Ser Pro Ser Leu  Asn Pro Gly 
    1805                 1810                 1815             


Asn Glu  Ser Gly Phe Val Asp  Met Cys Ser Leu Ser  Val Cys Asp 
    1820                 1825                 1830             


Ser Lys  Arg Asn Leu Ser Ser  Asp Gln Gln Leu Ile  Asp Leu Leu 
    1835                 1840                 1845             


Glu Asn  Lys Ser Leu Glu Ser  Lys Leu Ile Leu Ser  Gln Asn His 
    1850                 1855                 1860             


Ser Asp  Glu Glu Glu Glu Glu  Glu Glu Asn Glu Glu  Glu Asn Leu 
    1865                 1870                 1875             


Ala Met  Ala Val Gly Met Gly  Glu Arg Pro Glu Val  Leu His Leu 
    1880                 1885                 1890             


Thr Glu  Pro Thr Thr Asn Ile  Ser Arg Glu Lys Asn  Gln Gly Phe 
    1895                 1900                 1905             


Gln Asp  Glu Thr Lys Lys Gly  Ser Leu Glu Val Ala  Asn Gln Thr 
    1910                 1915                 1920             


Pro Gly  Leu Gln Arg Ala Phe  Pro Ala Pro Ala Ala  Cys Gln Cys 
    1925                 1930                 1935             


His Cys  Lys His Met Glu Arg  Trp Met His Gly Leu  Glu Asn Asp 
    1940                 1945                 1950             


Glu Phe  Glu Ile Glu Lys Pro  Lys Ala Tyr Ile Pro  Asp Leu Phe 
    1955                 1960                 1965             


Lys Ser  Lys Thr Asn Thr Ile  Ala Met Glu Gly Glu  Pro Thr Ala 
    1970                 1975                 1980             


Ile Pro  Ser Gln Pro Phe Lys  Val Lys His Glu Leu  Leu Lys Glu 
    1985                 1990                 1995             


Pro Trp  Lys Glu Ser Ala Glu  Gly Gln Asn Val Phe  Pro Thr Tyr 
    2000                 2005                 2010             


Pro Leu  Glu Gly Ser Glu Leu  Lys Ser Glu Asp Met  Asp Phe Glu 
    2015                 2020                 2025             


Asn Lys  Asp Asp Tyr Asp Arg  Asp Gly Asn Cys His  Ser Gln Asp 
    2030                 2035                 2040             


Tyr Pro  Gly Lys Tyr Ser Glu  Glu Glu Ser Lys Ser  Ser Thr Ser 
    2045                 2050                 2055             


Gly Ile  Thr Gly Asp Ile Gly  Asp Glu Leu Gln Glu  Ala Arg Ala 
    2060                 2065                 2070             


Pro Thr  Ile Ala Gln Leu Leu  Gln Glu Lys Thr Leu  Tyr Ser Phe 
    2075                 2080                 2085             


Ser Glu  Trp Pro Lys Asp Arg  Val Ile Ile Asn Arg  Leu Asp Asn 
    2090                 2095                 2100             


Ile Cys  His Val Val Leu Lys  Gly Lys Trp Pro Ser  Ser Gln Gln 
    2105                 2110                 2115             


Tyr Glu  Pro Ser Gly Thr Leu  Pro Thr Pro Val Leu  Thr Ser Ser 
    2120                 2125                 2130             


Ala Gly  Ser Arg Thr Ser Leu  Ser Glu Pro Glu Ala  Ala Glu His 
    2135                 2140                 2145             


Ser Phe  Ser Asn Gly Ala Ala  Leu Ala Ala Gln Ile  His Lys Glu 
    2150                 2155                 2160             


Ser Phe  Leu Ala Pro Val Phe  Thr Lys Asp Glu Gln  Lys His Arg 
    2165                 2170                 2175             


Arg Pro  Tyr Glu Phe Glu Val  Glu Arg Asp Ala Lys  Ala Arg Gly 
    2180                 2185                 2190             


Leu Glu  Gln Phe Ser Ala Thr  His Gly His Thr Pro  Ile Ile Leu 
    2195                 2200                 2205             


Asn Gly  Trp His Gly Glu Ser  Ala Met Asp Leu Ser  Cys Ser Ser 
    2210                 2215                 2220             


Glu Gly  Ser Pro Gly Ala Thr  Ser Pro Phe Pro Val  Ser Ala Ser 
    2225                 2230                 2235             


Thr Pro  Lys Ile Gly Ala Ile  Ser Ser Leu Gln Gly  Ala Leu Gly 
    2240                 2245                 2250             


Met Asp  Leu Ser Gly Ile Leu  Gln Ala Gly Leu Ile  His Pro Val 
    2255                 2260                 2265             


Thr Gly  Gln Ile Val Asn Gly  Ser Leu Arg Arg Asp  Asp Ala Ala 
    2270                 2275                 2280             


Thr Arg  Arg Arg Arg Gly Arg  Arg Lys His Val Glu  Gly Gly Met 
    2285                 2290                 2295             


Asp Leu  Ile Phe Leu Lys Glu  Gln Thr Leu Gln Ala  Gly Ile Leu 
    2300                 2305                 2310             


Glu Val  His Glu Asp Pro Gly  Gln Ala Thr Leu Ser  Thr Thr His 
    2315                 2320                 2325             


Pro Glu  Gly Pro Gly Pro Ala  Thr Ser Ala Pro Glu  Pro Ala Thr 
    2330                 2335                 2340             


Ala Ala  Ser Ser Gln Ala Glu  Lys Ser Ile Pro Ser  Lys Ser Leu 
    2345                 2350                 2355             


Leu Asp  Trp Leu Arg Gln Gln  Ala Asp Tyr Ser Leu  Glu Val Pro 
    2360                 2365                 2370             


Gly Phe  Gly Ala Asn Phe Ser  Asp Lys Pro Lys Gln  Arg Arg Pro 
    2375                 2380                 2385             


Arg Cys  Lys Glu Pro Gly Lys  Leu Asp Val Ser Ser  Leu Ser Gly 
    2390                 2395                 2400             


Glu Glu  Arg Val Pro Ala Ile  Pro Lys Glu Pro Gly  Leu Arg Gly 
    2405                 2410                 2415             


Phe Leu  Pro Glu Asn Lys Phe  Asn His Thr Leu Ala  Glu Pro Ile 
    2420                 2425                 2430             


Leu Arg  Asp Thr Gly Pro Arg  Arg Arg Gly Arg Arg  Pro Arg Ser 
    2435                 2440                 2445             


Glu Leu  Leu Lys Ala Pro Ser  Ile Val Ala Asp Ser  Pro Ser Gly 
    2450                 2455                 2460             


Met Gly  Pro Leu Phe Met Asn  Gly Leu Ile Ala Gly  Met Asp Leu 
    2465                 2470                 2475             


Val Gly  Leu Gln Asn Met Arg  Asn Met Pro Gly Ile  Pro Leu Thr 
    2480                 2485                 2490             


Gly Leu  Val Gly Phe Pro Ala  Gly Phe Ala Thr Met  Pro Thr Gly 
    2495                 2500                 2505             


Glu Glu  Val Lys Ser Thr Leu  Ser Met Leu Pro Met  Met Leu Pro 
    2510                 2515                 2520             


Gly Met  Ala Ala Val Pro Gln  Met Phe Gly Val Gly  Gly Leu Leu 
    2525                 2530                 2535             


Ser Pro  Pro Met Ala Thr Thr  Cys Thr Ser Thr Ala  Pro Ala Ser 
    2540                 2545                 2550             


Leu Ser  Ser Thr Thr Lys Ser  Gly Thr Ala Val Thr  Glu Lys Thr 
    2555                 2560                 2565             


Ala Glu  Asp Lys Pro Ser Ser  His Asp Val Lys Thr  Asp Thr Leu 
    2570                 2575                 2580             


Ala Glu  Asp Lys Pro Gly Pro  Gly Pro Phe Ser Asp  Gln Ser Glu 
    2585                 2590                 2595             


Pro Ala  Ile Thr Thr Ser Ser  Pro Val Ala Phe Asn  Pro Phe Leu 
    2600                 2605                 2610             


Ile Pro  Gly Val Ser Pro Gly  Leu Ile Tyr Pro Ser  Met Phe Leu 
    2615                 2620                 2625             


Ser Pro  Gly Met Gly Met Ala  Leu Pro Ala Met Gln  Gln Ala Arg 
    2630                 2635                 2640             


His Ser  Glu Ile Val Gly Leu  Glu Ser Gln Lys Arg  Lys Lys Lys 
    2645                 2650                 2655             


Lys Thr  Lys Gly Asp Asn Pro  Asn Ser His Pro Glu  Pro Ala Pro 
    2660                 2665                 2670             


Ser Cys  Glu Arg Glu Pro Ser  Gly Asp Glu Asn Cys  Ala Glu Pro 
    2675                 2680                 2685             


Ser Ala  Pro Leu Pro Ala Glu  Arg Glu His Gly Ala  Gln Ala Gly 
    2690                 2695                 2700             


Glu Gly  Ala Leu Lys Asp Ser  Asn Asn Asp Thr Asn  
    2705                 2710                 2715 


<210>  2116
<211>  2997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHD7__Homo_sapiens__NP_060250

<400>  2116

Met Ala Asp Pro Gly Met Met Ser Leu Phe Gly Glu Asp Gly Asn Ile 
1               5                   10                  15      


Phe Ser Glu Gly Leu Glu Gly Leu Gly Glu Cys Gly Tyr Pro Glu Asn 
            20                  25                  30          


Pro Val Asn Pro Met Gly Gln Gln Met Pro Ile Asp Gln Gly Phe Ala 
        35                  40                  45              


Ser Leu Gln Pro Ser Leu His His Pro Ser Thr Asn Gln Asn Gln Thr 
    50                  55                  60                  


Lys Leu Thr His Phe Asp His Tyr Asn Gln Tyr Glu Gln Gln Lys Met 
65                  70                  75                  80  


His Leu Met Asp Gln Pro Asn Arg Met Met Ser Asn Thr Pro Gly Asn 
                85                  90                  95      


Gly Leu Ala Ser Pro His Ser Gln Tyr His Thr Pro Pro Val Pro Gln 
            100                 105                 110         


Val Pro His Gly Gly Ser Gly Gly Gly Gln Met Gly Val Tyr Pro Gly 
        115                 120                 125             


Met Gln Asn Glu Arg His Gly Gln Ser Phe Val Asp Ser Ser Ser Met 
    130                 135                 140                 


Trp Gly Pro Arg Ala Val Gln Val Pro Asp Gln Ile Arg Ala Pro Tyr 
145                 150                 155                 160 


Gln Gln Gln Gln Pro Gln Pro Gln Pro Pro Gln Pro Ala Pro Ser Gly 
                165                 170                 175     


Pro Pro Ala Gln Gly His Pro Gln His Met Gln Gln Met Gly Ser Tyr 
            180                 185                 190         


Met Ala Arg Gly Asp Phe Ser Met Gln Gln His Gly Gln Pro Gln Gln 
        195                 200                 205             


Arg Met Ser Gln Phe Ser Gln Gly Gln Glu Gly Leu Asn Gln Gly Asn 
    210                 215                 220                 


Pro Phe Ile Ala Thr Ser Gly Pro Gly His Leu Ser His Val Pro Gln 
225                 230                 235                 240 


Gln Ser Pro Ser Met Ala Pro Ser Leu Arg His Ser Val Gln Gln Phe 
                245                 250                 255     


His His His Pro Ser Thr Ala Leu His Gly Glu Ser Val Ala His Ser 
            260                 265                 270         


Pro Arg Phe Ser Pro Asn Pro Pro Gln Gln Gly Ala Val Arg Pro Gln 
        275                 280                 285             


Thr Leu Asn Phe Ser Ser Arg Ser Gln Thr Val Pro Ser Pro Thr Ile 
    290                 295                 300                 


Asn Asn Ser Gly Gln Tyr Ser Arg Tyr Pro Tyr Ser Asn Leu Asn Gln 
305                 310                 315                 320 


Gly Leu Val Asn Asn Thr Gly Met Asn Gln Asn Leu Gly Leu Thr Asn 
                325                 330                 335     


Asn Thr Pro Met Asn Gln Ser Val Pro Arg Tyr Pro Asn Ala Val Gly 
            340                 345                 350         


Phe Pro Ser Asn Ser Gly Gln Gly Leu Met His Gln Gln Pro Ile His 
        355                 360                 365             


Pro Ser Gly Ser Leu Asn Gln Met Asn Thr Gln Thr Met His Pro Ser 
    370                 375                 380                 


Gln Pro Gln Gly Thr Tyr Ala Ser Pro Pro Pro Met Ser Pro Met Lys 
385                 390                 395                 400 


Ala Met Ser Asn Pro Ala Gly Thr Pro Pro Pro Gln Val Arg Pro Gly 
                405                 410                 415     


Ser Ala Gly Ile Pro Met Glu Val Gly Ser Tyr Pro Asn Met Pro His 
            420                 425                 430         


Pro Gln Pro Ser His Gln Pro Pro Gly Ala Met Gly Ile Gly Gln Arg 
        435                 440                 445             


Asn Met Gly Pro Arg Asn Met Gln Gln Ser Arg Pro Phe Ile Gly Met 
    450                 455                 460                 


Ser Ser Ala Pro Arg Glu Leu Thr Gly His Met Arg Pro Asn Gly Cys 
465                 470                 475                 480 


Pro Gly Val Gly Leu Gly Asp Pro Gln Ala Ile Gln Glu Arg Leu Ile 
                485                 490                 495     


Pro Gly Gln Gln His Pro Gly Gln Gln Pro Ser Phe Gln Gln Leu Pro 
            500                 505                 510         


Thr Cys Pro Pro Leu Gln Pro His Pro Gly Leu His His Gln Ser Ser 
        515                 520                 525             


Pro Pro His Pro His His Gln Pro Trp Ala Gln Leu His Pro Ser Pro 
    530                 535                 540                 


Gln Asn Thr Pro Gln Lys Val Pro Val His Gln His Ser Pro Ser Glu 
545                 550                 555                 560 


Pro Phe Leu Glu Lys Pro Val Pro Asp Met Thr Gln Val Ser Gly Pro 
                565                 570                 575     


Asn Ala Gln Leu Val Lys Ser Asp Asp Tyr Leu Pro Ser Ile Glu Gln 
            580                 585                 590         


Gln Pro Gln Gln Lys Lys Lys Lys Lys Lys Asn Asn His Ile Val Ala 
        595                 600                 605             


Glu Asp Pro Ser Lys Gly Phe Gly Lys Asp Asp Phe Pro Gly Gly Val 
    610                 615                 620                 


Asp Asn Gln Glu Leu Asn Arg Asn Ser Leu Asp Gly Ser Gln Glu Glu 
625                 630                 635                 640 


Lys Lys Lys Lys Lys Arg Ser Lys Ala Lys Lys Asp Pro Lys Glu Pro 
                645                 650                 655     


Lys Glu Pro Lys Glu Lys Lys Glu Pro Lys Glu Pro Lys Thr Pro Lys 
            660                 665                 670         


Ala Pro Lys Ile Pro Lys Glu Pro Lys Glu Lys Lys Ala Lys Thr Ala 
        675                 680                 685             


Thr Pro Lys Pro Lys Ser Ser Lys Lys Ser Ser Asn Lys Lys Pro Asp 
    690                 695                 700                 


Ser Glu Ala Ser Ala Leu Lys Lys Lys Val Asn Lys Gly Lys Thr Glu 
705                 710                 715                 720 


Gly Ser Glu Asn Ser Asp Leu Asp Lys Thr Pro Pro Pro Ser Pro Pro 
                725                 730                 735     


Pro Glu Glu Asp Glu Asp Pro Gly Val Gln Lys Arg Arg Ser Ser Arg 
            740                 745                 750         


Gln Val Lys Arg Lys Arg Tyr Thr Glu Asp Leu Glu Phe Lys Ile Ser 
        755                 760                 765             


Asp Glu Glu Ala Asp Asp Ala Asp Ala Ala Gly Arg Asp Ser Pro Ser 
    770                 775                 780                 


Asn Thr Ser Gln Ser Glu Gln Gln Glu Ser Val Asp Ala Glu Gly Pro 
785                 790                 795                 800 


Val Val Glu Lys Ile Met Ser Ser Arg Ser Val Lys Lys Gln Lys Glu 
                805                 810                 815     


Ser Gly Glu Glu Val Glu Ile Glu Glu Phe Tyr Val Lys Tyr Lys Asn 
            820                 825                 830         


Phe Ser Tyr Leu His Cys Gln Trp Ala Ser Ile Glu Asp Leu Glu Lys 
        835                 840                 845             


Asp Lys Arg Ile Gln Gln Lys Ile Lys Arg Phe Lys Ala Lys Gln Gly 
    850                 855                 860                 


Gln Asn Lys Phe Leu Ser Glu Ile Glu Asp Glu Leu Phe Asn Pro Asp 
865                 870                 875                 880 


Tyr Val Glu Val Asp Arg Ile Met Asp Phe Ala Arg Ser Thr Asp Asp 
                885                 890                 895     


Arg Gly Glu Pro Val Thr His Tyr Leu Val Lys Trp Cys Ser Leu Pro 
            900                 905                 910         


Tyr Glu Asp Ser Thr Trp Glu Arg Arg Gln Asp Ile Asp Gln Ala Lys 
        915                 920                 925             


Ile Glu Glu Phe Glu Lys Leu Met Ser Arg Glu Pro Glu Thr Glu Arg 
    930                 935                 940                 


Val Glu Arg Pro Pro Ala Asp Asp Trp Lys Lys Ser Glu Ser Ser Arg 
945                 950                 955                 960 


Glu Tyr Lys Asn Asn Asn Lys Leu Arg Glu Tyr Gln Leu Glu Gly Val 
                965                 970                 975     


Asn Trp Leu Leu Phe Asn Trp Tyr Asn Met Arg Asn Cys Ile Leu Ala 
            980                 985                 990         


Asp Glu Met Gly Leu Gly Lys Thr  Ile Gln Ser Ile Thr  Phe Leu Tyr 
        995                 1000                 1005             


Glu Ile  Tyr Leu Lys Gly Ile  His Gly Pro Phe Leu  Val Ile Ala 
    1010                 1015                 1020             


Pro Leu  Ser Thr Ile Pro Asn  Trp Glu Arg Glu Phe  Arg Thr Trp 
    1025                 1030                 1035             


Thr Glu  Leu Asn Val Val Val  Tyr His Gly Ser Gln  Ala Ser Arg 
    1040                 1045                 1050             


Arg Thr  Ile Gln Leu Tyr Glu  Met Tyr Phe Lys Asp  Pro Gln Gly 
    1055                 1060                 1065             


Arg Val  Ile Lys Gly Ser Tyr  Lys Phe His Ala Ile  Ile Thr Thr 
    1070                 1075                 1080             


Phe Glu  Met Ile Leu Thr Asp  Cys Pro Glu Leu Arg  Asn Ile Pro 
    1085                 1090                 1095             


Trp Arg  Cys Val Val Ile Asp  Glu Ala His Arg Leu  Lys Asn Arg 
    1100                 1105                 1110             


Asn Cys  Lys Leu Leu Glu Gly  Leu Lys Met Met Asp  Leu Glu His 
    1115                 1120                 1125             


Lys Val  Leu Leu Thr Gly Thr  Pro Leu Gln Asn Thr  Val Glu Glu 
    1130                 1135                 1140             


Leu Phe  Ser Leu Leu His Phe  Leu Glu Pro Ser Arg  Phe Pro Ser 
    1145                 1150                 1155             


Glu Thr  Thr Phe Met Gln Glu  Phe Gly Asp Leu Lys  Thr Glu Glu 
    1160                 1165                 1170             


Gln Val  Gln Lys Leu Gln Ala  Ile Leu Lys Pro Met  Met Leu Arg 
    1175                 1180                 1185             


Arg Leu  Lys Glu Asp Val Glu  Lys Asn Leu Ala Pro  Lys Glu Glu 
    1190                 1195                 1200             


Thr Ile  Ile Glu Val Glu Leu  Thr Asn Ile Gln Lys  Lys Tyr Tyr 
    1205                 1210                 1215             


Arg Ala  Ile Leu Glu Lys Asn  Phe Thr Phe Leu Ser  Lys Gly Gly 
    1220                 1225                 1230             


Gly Gln  Ala Asn Val Pro Asn  Leu Leu Asn Thr Met  Met Glu Leu 
    1235                 1240                 1245             


Arg Lys  Cys Cys Asn His Pro  Tyr Leu Ile Asn Gly  Ala Glu Glu 
    1250                 1255                 1260             


Lys Ile  Leu Glu Glu Phe Lys  Glu Thr His Asn Ala  Glu Ser Pro 
    1265                 1270                 1275             


Asp Phe  Gln Leu Gln Ala Met  Ile Gln Ala Ala Gly  Lys Leu Val 
    1280                 1285                 1290             


Leu Ile  Asp Lys Leu Leu Pro  Lys Leu Lys Ala Gly  Gly His Arg 
    1295                 1300                 1305             


Val Leu  Ile Phe Ser Gln Met  Val Arg Cys Leu Asp  Ile Leu Glu 
    1310                 1315                 1320             


Asp Tyr  Leu Ile Gln Arg Arg  Tyr Pro Tyr Glu Arg  Ile Asp Gly 
    1325                 1330                 1335             


Arg Val  Arg Gly Asn Leu Arg  Gln Ala Ala Ile Asp  Arg Phe Ser 
    1340                 1345                 1350             


Lys Pro  Asp Ser Asp Arg Phe  Val Phe Leu Leu Cys  Thr Arg Ala 
    1355                 1360                 1365             


Gly Gly  Leu Gly Ile Asn Leu  Thr Ala Ala Asp Thr  Cys Ile Ile 
    1370                 1375                 1380             


Phe Asp  Ser Asp Trp Asn Pro  Gln Asn Asp Leu Gln  Ala Gln Ala 
    1385                 1390                 1395             


Arg Cys  His Arg Ile Gly Gln  Ser Lys Ser Val Lys  Ile Tyr Arg 
    1400                 1405                 1410             


Leu Ile  Thr Arg Asn Ser Tyr  Glu Arg Glu Met Phe  Asp Lys Ala 
    1415                 1420                 1425             


Ser Leu  Lys Leu Gly Leu Asp  Lys Ala Val Leu Gln  Ser Met Ser 
    1430                 1435                 1440             


Gly Arg  Glu Asn Ala Thr Asn  Gly Val Gln Gln Leu  Ser Lys Lys 
    1445                 1450                 1455             


Glu Ile  Glu Asp Leu Leu Arg  Lys Gly Ala Tyr Gly  Ala Leu Met 
    1460                 1465                 1470             


Asp Glu  Glu Asp Glu Gly Ser  Lys Phe Cys Glu Glu  Asp Ile Asp 
    1475                 1480                 1485             


Gln Ile  Leu Leu Arg Arg Thr  His Thr Ile Thr Ile  Glu Ser Glu 
    1490                 1495                 1500             


Gly Lys  Gly Ser Thr Phe Ala  Lys Ala Ser Phe Val  Ala Ser Gly 
    1505                 1510                 1515             


Asn Arg  Thr Asp Ile Ser Leu  Asp Asp Pro Asn Phe  Trp Gln Lys 
    1520                 1525                 1530             


Trp Ala  Lys Lys Ala Glu Leu  Asp Ile Asp Ala Leu  Asn Gly Arg 
    1535                 1540                 1545             


Asn Asn  Leu Val Ile Asp Thr  Pro Arg Val Arg Lys  Gln Thr Arg 
    1550                 1555                 1560             


Leu Tyr  Ser Ala Val Lys Glu  Asp Glu Leu Met Glu  Phe Ser Asp 
    1565                 1570                 1575             


Leu Glu  Ser Asp Ser Glu Glu  Lys Pro Cys Ala Lys  Pro Arg Arg 
    1580                 1585                 1590             


Pro Gln  Asp Lys Ser Gln Gly  Tyr Ala Arg Ser Glu  Cys Phe Arg 
    1595                 1600                 1605             


Val Glu  Lys Asn Leu Leu Val  Tyr Gly Trp Gly Arg  Trp Thr Asp 
    1610                 1615                 1620             


Ile Leu  Ser His Gly Arg Tyr  Lys Arg Gln Leu Thr  Glu Gln Asp 
    1625                 1630                 1635             


Val Glu  Thr Ile Cys Arg Thr  Ile Leu Val Tyr Cys  Leu Asn His 
    1640                 1645                 1650             


Tyr Lys  Gly Asp Glu Asn Ile  Lys Ser Phe Ile Trp  Asp Leu Ile 
    1655                 1660                 1665             


Thr Pro  Thr Ala Asp Gly Gln  Thr Arg Ala Leu Val  Asn His Ser 
    1670                 1675                 1680             


Gly Leu  Ser Ala Pro Val Pro  Arg Gly Arg Lys Gly  Lys Lys Val 
    1685                 1690                 1695             


Lys Ala  Gln Ser Thr Gln Pro  Val Val Gln Asp Ala  Asp Trp Leu 
    1700                 1705                 1710             


Ala Ser  Cys Asn Pro Asp Ala  Leu Phe Gln Glu Asp  Ser Tyr Lys 
    1715                 1720                 1725             


Lys His  Leu Lys His His Cys  Asn Lys Val Leu Leu  Arg Val Arg 
    1730                 1735                 1740             


Met Leu  Tyr Tyr Leu Arg Gln  Glu Val Ile Gly Asp  Gln Ala Asp 
    1745                 1750                 1755             


Lys Ile  Leu Glu Gly Ala Asp  Ser Ser Glu Ala Asp  Val Trp Ile 
    1760                 1765                 1770             


Pro Glu  Pro Phe His Ala Glu  Val Pro Ala Asp Trp  Trp Asp Lys 
    1775                 1780                 1785             


Glu Ala  Asp Lys Ser Leu Leu  Ile Gly Val Phe Lys  His Gly Tyr 
    1790                 1795                 1800             


Glu Lys  Tyr Asn Ser Met Arg  Ala Asp Pro Ala Leu  Cys Phe Leu 
    1805                 1810                 1815             


Glu Arg  Val Gly Met Pro Asp  Ala Lys Ala Ile Ala  Ala Glu Gln 
    1820                 1825                 1830             


Arg Gly  Thr Asp Met Leu Ala  Asp Gly Gly Asp Gly  Gly Glu Phe 
    1835                 1840                 1845             


Asp Arg  Glu Asp Glu Asp Pro  Glu Tyr Lys Pro Thr  Arg Thr Pro 
    1850                 1855                 1860             


Phe Lys  Asp Glu Ile Asp Glu  Phe Ala Asn Ser Pro  Ser Glu Asp 
    1865                 1870                 1875             


Lys Glu  Glu Ser Met Glu Ile  His Ala Thr Gly Lys  His Ser Glu 
    1880                 1885                 1890             


Ser Asn  Ala Glu Leu Gly Gln  Leu Tyr Trp Pro Asn  Thr Ser Thr 
    1895                 1900                 1905             


Leu Thr  Thr Arg Leu Arg Arg  Leu Ile Thr Ala Tyr  Gln Arg Ser 
    1910                 1915                 1920             


Tyr Lys  Arg Gln Gln Met Arg  Gln Glu Ala Leu Met  Lys Thr Asp 
    1925                 1930                 1935             


Arg Arg  Arg Arg Arg Pro Arg  Glu Glu Val Arg Ala  Leu Glu Ala 
    1940                 1945                 1950             


Glu Arg  Glu Ala Ile Ile Ser  Glu Lys Arg Gln Lys  Trp Thr Arg 
    1955                 1960                 1965             


Arg Glu  Glu Ala Asp Phe Tyr  Arg Val Val Ser Thr  Phe Gly Val 
    1970                 1975                 1980             


Ile Phe  Asp Pro Val Lys Gln  Gln Phe Asp Trp Asn  Gln Phe Arg 
    1985                 1990                 1995             


Ala Phe  Ala Arg Leu Asp Lys  Lys Ser Asp Glu Ser  Leu Glu Lys 
    2000                 2005                 2010             


Tyr Phe  Ser Cys Phe Val Ala  Met Cys Arg Arg Val  Cys Arg Met 
    2015                 2020                 2025             


Pro Val  Lys Pro Asp Asp Glu  Pro Pro Asp Leu Ser  Ser Ile Ile 
    2030                 2035                 2040             


Glu Pro  Ile Thr Glu Glu Arg  Ala Ser Arg Thr Leu  Tyr Arg Ile 
    2045                 2050                 2055             


Glu Leu  Leu Arg Lys Ile Arg  Glu Gln Val Leu His  His Pro Gln 
    2060                 2065                 2070             


Leu Gly  Glu Arg Leu Lys Leu  Cys Gln Pro Ser Leu  Asp Leu Pro 
    2075                 2080                 2085             


Glu Trp  Trp Glu Cys Gly Arg  His Asp Arg Asp Leu  Leu Val Gly 
    2090                 2095                 2100             


Ala Ala  Lys His Gly Val Ser  Arg Thr Asp Tyr His  Ile Leu Asn 
    2105                 2110                 2115             


Asp Pro  Glu Leu Ser Phe Leu  Asp Ala His Lys Asn  Phe Ala Gln 
    2120                 2125                 2130             


Asn Arg  Gly Ala Gly Asn Thr  Ser Ser Leu Asn Pro  Leu Ala Val 
    2135                 2140                 2145             


Gly Phe  Val Gln Thr Pro Pro  Val Ile Ser Ser Ala  His Ile Gln 
    2150                 2155                 2160             


Asp Glu  Arg Val Leu Glu Gln  Ala Glu Gly Lys Val  Glu Glu Pro 
    2165                 2170                 2175             


Glu Asn  Pro Ala Ala Lys Glu  Lys Cys Glu Gly Lys  Glu Glu Glu 
    2180                 2185                 2190             


Glu Glu  Thr Asp Gly Ser Gly  Lys Glu Ser Lys Gln  Glu Cys Glu 
    2195                 2200                 2205             


Ala Glu  Ala Ser Ser Val Lys  Asn Glu Leu Lys Gly  Val Glu Val 
    2210                 2215                 2220             


Gly Ala  Asp Thr Gly Ser Lys  Ser Ile Ser Glu Lys  Gly Ser Glu 
    2225                 2230                 2235             


Glu Asp  Glu Glu Glu Lys Leu  Glu Asp Asp Asp Lys  Ser Glu Glu 
    2240                 2245                 2250             


Ser Ser  Gln Pro Glu Ala Gly  Ala Val Ser Arg Gly  Lys Asn Phe 
    2255                 2260                 2265             


Asp Glu  Glu Ser Asn Ala Ser  Met Ser Thr Ala Arg  Asp Glu Thr 
    2270                 2275                 2280             


Arg Asp  Gly Phe Tyr Met Glu  Asp Gly Asp Pro Ser  Val Ala Gln 
    2285                 2290                 2295             


Leu Leu  His Glu Arg Thr Phe  Ala Phe Ser Phe Trp  Pro Lys Asp 
    2300                 2305                 2310             


Arg Val  Met Ile Asn Arg Leu  Asp Asn Ile Cys Glu  Ala Val Leu 
    2315                 2320                 2325             


Lys Gly  Lys Trp Pro Val Asn  Arg Arg Gln Met Phe  Asp Phe Gln 
    2330                 2335                 2340             


Gly Leu  Ile Pro Gly Tyr Thr  Pro Thr Thr Val Asp  Ser Pro Leu 
    2345                 2350                 2355             


Gln Lys  Arg Ser Phe Ala Glu  Leu Ser Met Val Gly  Gln Ala Ser 
    2360                 2365                 2370             


Ile Ser  Gly Ser Glu Asp Ile  Thr Thr Ser Pro Gln  Leu Ser Lys 
    2375                 2380                 2385             


Glu Asp  Ala Leu Asn Leu Ser  Val Pro Arg Gln Arg  Arg Arg Arg 
    2390                 2395                 2400             


Arg Arg  Lys Ile Glu Ile Glu  Ala Glu Arg Ala Ala  Lys Arg Arg 
    2405                 2410                 2415             


Asn Leu  Met Glu Met Val Ala  Gln Leu Arg Glu Ser  Gln Val Val 
    2420                 2425                 2430             


Ser Glu  Asn Gly Gln Glu Lys  Val Val Asp Leu Ser  Lys Ala Ser 
    2435                 2440                 2445             


Arg Glu  Ala Thr Ser Ser Thr  Ser Asn Phe Ser Ser  Leu Ser Ser 
    2450                 2455                 2460             


Lys Phe  Ile Leu Pro Asn Val  Ser Thr Pro Val Ser  Asp Ala Phe 
    2465                 2470                 2475             


Lys Thr  Gln Met Glu Leu Leu  Gln Ala Gly Leu Ser  Arg Thr Pro 
    2480                 2485                 2490             


Thr Arg  His Leu Leu Asn Gly  Ser Leu Val Asp Gly  Glu Pro Pro 
    2495                 2500                 2505             


Met Lys  Arg Arg Arg Gly Arg  Arg Lys Asn Val Glu  Gly Leu Asp 
    2510                 2515                 2520             


Leu Leu  Phe Met Ser His Lys  Arg Thr Ser Leu Ser  Ala Glu Asp 
    2525                 2530                 2535             


Ala Glu  Val Thr Lys Ala Phe  Glu Glu Asp Ile Glu  Thr Pro Pro 
    2540                 2545                 2550             


Thr Arg  Asn Ile Pro Ser Pro  Gly Gln Leu Asp Pro  Asp Thr Arg 
    2555                 2560                 2565             


Ile Pro  Val Ile Asn Leu Glu  Asp Gly Thr Arg Leu  Val Gly Glu 
    2570                 2575                 2580             


Asp Ala  Pro Lys Asn Lys Asp  Leu Val Glu Trp Leu  Lys Leu His 
    2585                 2590                 2595             


Pro Thr  Tyr Thr Val Asp Met  Pro Ser Tyr Val Pro  Lys Asn Ala 
    2600                 2605                 2610             


Asp Val  Leu Phe Ser Ser Phe  Gln Lys Pro Lys Gln  Lys Arg His 
    2615                 2620                 2625             


Arg Cys  Arg Asn Pro Asn Lys  Leu Asp Ile Asn Thr  Leu Thr Gly 
    2630                 2635                 2640             


Glu Glu  Arg Val Pro Val Val  Asn Lys Arg Asn Gly  Lys Lys Met 
    2645                 2650                 2655             


Gly Gly  Ala Met Ala Pro Pro  Met Lys Asp Leu Pro  Arg Trp Leu 
    2660                 2665                 2670             


Glu Glu  Asn Pro Glu Phe Ala  Val Ala Pro Asp Trp  Thr Asp Ile 
    2675                 2680                 2685             


Val Lys  Gln Ser Gly Phe Val  Pro Glu Ser Met Phe  Asp Arg Leu 
    2690                 2695                 2700             


Leu Thr  Gly Pro Val Val Arg  Gly Glu Gly Ala Ser  Arg Arg Gly 
    2705                 2710                 2715             


Arg Arg  Pro Lys Ser Glu Ile  Ala Arg Ala Ala Ala  Ala Ala Ala 
    2720                 2725                 2730             


Ala Val  Ala Ser Thr Ser Gly  Ile Asn Pro Leu Leu  Val Asn Ser 
    2735                 2740                 2745             


Leu Phe  Ala Gly Met Asp Leu  Thr Ser Leu Gln Asn  Leu Gln Asn 
    2750                 2755                 2760             


Leu Gln  Ser Leu Gln Leu Ala  Gly Leu Met Gly Phe  Pro Pro Gly 
    2765                 2770                 2775             


Leu Ala  Thr Ala Ala Thr Ala  Gly Gly Asp Ala Lys  Asn Pro Ala 
    2780                 2785                 2790             


Ala Val  Leu Pro Leu Met Leu  Pro Gly Met Ala Gly  Leu Pro Asn 
    2795                 2800                 2805             


Val Phe  Gly Leu Gly Gly Leu  Leu Asn Asn Pro Leu  Ser Ala Ala 
    2810                 2815                 2820             


Thr Gly  Asn Thr Thr Thr Ala  Ser Ser Gln Gly Glu  Pro Glu Asp 
    2825                 2830                 2835             


Ser Thr  Ser Lys Gly Glu Glu  Lys Gly Asn Glu Asn  Glu Asp Glu 
    2840                 2845                 2850             


Asn Lys  Asp Ser Glu Lys Ser  Thr Asp Ala Val Ser  Ala Ala Asp 
    2855                 2860                 2865             


Ser Ala  Asn Gly Ser Val Gly  Ala Ala Thr Ala Pro  Ala Gly Leu 
    2870                 2875                 2880             


Pro Ser  Asn Pro Leu Ala Phe  Asn Pro Phe Leu Leu  Ser Thr Met 
    2885                 2890                 2895             


Ala Pro  Gly Leu Phe Tyr Pro  Ser Met Phe Leu Pro  Pro Gly Leu 
    2900                 2905                 2910             


Gly Gly  Leu Thr Leu Pro Gly  Phe Pro Ala Leu Ala  Gly Leu Gln 
    2915                 2920                 2925             


Asn Ala  Val Gly Ser Ser Glu  Glu Lys Ala Ala Asp  Lys Ala Glu 
    2930                 2935                 2940             


Gly Gly  Pro Phe Lys Asp Gly  Glu Thr Leu Glu Gly  Ser Asp Ala 
    2945                 2950                 2955             


Glu Glu  Ser Leu Asp Lys Thr  Ala Glu Ser Ser Leu  Leu Glu Asp 
    2960                 2965                 2970             


Glu Ile  Ala Gln Gly Glu Glu  Leu Asp Ser Leu Asp  Gly Gly Asp 
    2975                 2980                 2985             


Glu Ile  Glu Asn Asn Glu Asn  Asp Glu 
    2990                 2995         


<210>  2117
<211>  2581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHD8__Homo_sapiens__NP_001164100

<400>  2117

Met Ala Asp Pro Ile Met Asp Leu Phe Asp Asp Pro Asn Leu Phe Gly 
1               5                   10                  15      


Leu Asp Ser Leu Thr Asp Asp Ser Phe Asn Gln Val Thr Gln Asp Pro 
            20                  25                  30          


Ile Glu Glu Ala Leu Gly Leu Pro Ser Ser Leu Asp Ser Leu Asp Gln 
        35                  40                  45              


Met Asn Gln Asp Gly Gly Gly Gly Asp Val Gly Asn Ser Ser Ala Ser 
    50                  55                  60                  


Glu Leu Val Pro Pro Pro Glu Glu Thr Ala Pro Thr Glu Leu Ser Lys 
65                  70                  75                  80  


Glu Ser Thr Ala Pro Ala Pro Glu Ser Ile Thr Leu His Asp Tyr Thr 
                85                  90                  95      


Thr Gln Pro Ala Ser Gln Glu Gln Pro Ala Gln Pro Val Leu Gln Thr 
            100                 105                 110         


Ser Thr Pro Thr Ser Gly Leu Leu Gln Val Ser Lys Ser Gln Glu Ile 
        115                 120                 125             


Leu Ser Gln Gly Asn Pro Phe Met Gly Val Ser Ala Thr Ala Val Ser 
    130                 135                 140                 


Ser Ser Ser Ala Gly Gly Gln Pro Pro Gln Ser Ala Pro Lys Ile Val 
145                 150                 155                 160 


Ile Leu Lys Ala Pro Pro Ser Ser Ser Val Thr Gly Ala His Val Ala 
                165                 170                 175     


Gln Ile Gln Ala Gln Gly Ile Thr Ser Thr Ala Gln Pro Leu Val Ala 
            180                 185                 190         


Gly Thr Ala Asn Gly Gly Lys Val Thr Phe Thr Lys Val Leu Thr Gly 
        195                 200                 205             


Thr Pro Leu Arg Pro Gly Val Ser Ile Val Ser Gly Asn Thr Val Leu 
    210                 215                 220                 


Ala Ala Lys Val Pro Gly Asn Gln Ala Ala Val Gln Arg Ile Val Gln 
225                 230                 235                 240 


Pro Ser Arg Pro Val Lys Gln Leu Val Leu Gln Pro Val Lys Gly Ser 
                245                 250                 255     


Ala Pro Ala Gly Asn Pro Gly Ala Thr Gly Pro Pro Leu Lys Pro Ala 
            260                 265                 270         


Val Thr Leu Thr Ser Thr Pro Thr Gln Gly Glu Ser Lys Arg Ile Thr 
        275                 280                 285             


Leu Val Leu Gln Gln Pro Gln Ser Gly Gly Pro Gln Gly His Arg His 
    290                 295                 300                 


Val Val Leu Gly Ser Leu Pro Gly Lys Ile Val Leu Gln Gly Asn Gln 
305                 310                 315                 320 


Leu Ala Ala Leu Thr Gln Ala Lys Asn Ala Gln Gly Gln Pro Ala Lys 
                325                 330                 335     


Val Val Thr Ile Gln Leu Gln Val Gln Gln Pro Gln Gln Lys Ile Gln 
            340                 345                 350         


Ile Val Pro Gln Pro Pro Ser Ser Gln Pro Gln Pro Gln Gln Pro Pro 
        355                 360                 365             


Ser Thr Gln Pro Val Thr Leu Ser Ser Val Gln Gln Ala Gln Ile Met 
    370                 375                 380                 


Gly Pro Gly Gln Ser Pro Gly Gln Arg Leu Ser Val Pro Val Lys Val 
385                 390                 395                 400 


Val Leu Gln Pro Gln Ala Gly Ser Ser Gln Gly Ala Ser Ser Gly Leu 
                405                 410                 415     


Ser Val Val Lys Val Leu Ser Ala Ser Glu Val Ala Ala Leu Ser Ser 
            420                 425                 430         


Pro Ala Ser Ser Ala Pro His Ser Gly Gly Lys Thr Gly Met Glu Glu 
        435                 440                 445             


Asn Arg Arg Leu Glu His Gln Lys Lys Gln Glu Lys Ala Asn Arg Ile 
    450                 455                 460                 


Val Ala Glu Ala Ile Ala Arg Ala Arg Ala Arg Gly Glu Gln Asn Ile 
465                 470                 475                 480 


Pro Arg Val Leu Asn Glu Asp Glu Leu Pro Ser Val Arg Pro Glu Glu 
                485                 490                 495     


Glu Gly Glu Lys Lys Arg Arg Lys Lys Ser Ala Gly Glu Arg Leu Lys 
            500                 505                 510         


Glu Glu Lys Pro Lys Lys Ser Lys Thr Ser Gly Ala Ser Lys Thr Lys 
        515                 520                 525             


Gly Lys Ser Lys Leu Asn Thr Ile Thr Pro Val Val Gly Lys Lys Arg 
    530                 535                 540                 


Lys Arg Asn Thr Ser Ser Asp Asn Ser Asp Val Glu Val Met Pro Ala 
545                 550                 555                 560 


Gln Ser Pro Arg Glu Asp Glu Glu Ser Ser Ile Gln Lys Arg Arg Ser 
                565                 570                 575     


Asn Arg Gln Val Lys Arg Lys Lys Tyr Thr Glu Asp Leu Asp Ile Lys 
            580                 585                 590         


Ile Thr Asp Asp Glu Glu Glu Glu Glu Val Asp Val Thr Gly Pro Ile 
        595                 600                 605             


Lys Pro Glu Pro Ile Leu Pro Glu Pro Val Gln Glu Pro Asp Gly Glu 
    610                 615                 620                 


Thr Leu Pro Ser Met Gln Phe Phe Val Glu Asn Pro Ser Glu Glu Asp 
625                 630                 635                 640 


Ala Ala Ile Val Asp Lys Val Leu Ser Met Arg Ile Val Lys Lys Glu 
                645                 650                 655     


Leu Pro Ser Gly Gln Tyr Thr Glu Ala Glu Glu Phe Phe Val Lys Tyr 
            660                 665                 670         


Lys Asn Tyr Ser Tyr Leu His Cys Glu Trp Ala Thr Ile Ser Gln Leu 
        675                 680                 685             


Glu Lys Asp Lys Arg Ile His Gln Lys Leu Lys Arg Phe Lys Thr Lys 
    690                 695                 700                 


Met Ala Gln Met Arg His Phe Phe His Glu Asp Glu Glu Pro Phe Asn 
705                 710                 715                 720 


Pro Asp Tyr Val Glu Val Asp Arg Ile Leu Asp Glu Ser His Ser Ile 
                725                 730                 735     


Asp Lys Asp Asn Gly Glu Pro Val Ile Tyr Tyr Leu Val Lys Trp Cys 
            740                 745                 750         


Ser Leu Pro Tyr Glu Asp Ser Thr Trp Glu Leu Lys Glu Asp Val Asp 
        755                 760                 765             


Glu Gly Lys Ile Arg Glu Phe Lys Arg Ile Gln Ser Arg His Pro Glu 
    770                 775                 780                 


Leu Lys Arg Val Asn Arg Pro Gln Ala Ser Ala Trp Lys Lys Leu Glu 
785                 790                 795                 800 


Leu Ser His Glu Tyr Lys Asn Arg Asn Gln Leu Arg Glu Tyr Gln Leu 
                805                 810                 815     


Glu Gly Val Asn Trp Leu Leu Phe Asn Trp Tyr Asn Arg Gln Asn Cys 
            820                 825                 830         


Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ser Ile Ala 
        835                 840                 845             


Phe Leu Gln Glu Val Tyr Asn Val Gly Ile His Gly Pro Phe Leu Val 
    850                 855                 860                 


Ile Ala Pro Leu Ser Thr Ile Thr Asn Trp Glu Arg Glu Phe Asn Thr 
865                 870                 875                 880 


Trp Thr Glu Met Asn Thr Ile Val Tyr His Gly Ser Leu Ala Ser Arg 
                885                 890                 895     


Gln Met Ile Gln Gln Tyr Glu Met Tyr Cys Lys Asp Ser Arg Gly Arg 
            900                 905                 910         


Leu Ile Pro Gly Ala Tyr Lys Phe Asp Ala Leu Ile Thr Thr Phe Glu 
        915                 920                 925             


Met Ile Leu Ser Asp Cys Pro Glu Leu Arg Glu Ile Glu Trp Arg Cys 
    930                 935                 940                 


Val Ile Ile Asp Glu Ala His Arg Leu Lys Asn Arg Asn Cys Lys Leu 
945                 950                 955                 960 


Leu Asp Ser Leu Lys His Met Asp Leu Glu His Lys Val Leu Leu Thr 
                965                 970                 975     


Gly Thr Pro Leu Gln Asn Thr Val Glu Glu Leu Phe Ser Leu Leu His 
            980                 985                 990         


Phe Leu Glu Pro Ser Gln Phe Pro  Ser Glu Ser Glu Phe  Leu Lys Asp 
        995                 1000                 1005             


Phe Gly  Asp Leu Lys Thr Glu  Glu Gln Val Gln Lys  Leu Gln Ala 
    1010                 1015                 1020             


Ile Leu  Lys Pro Met Met Leu  Arg Arg Leu Lys Glu  Asp Val Glu 
    1025                 1030                 1035             


Lys Asn  Leu Ala Pro Lys Gln  Glu Thr Ile Ile Glu  Val Glu Leu 
    1040                 1045                 1050             


Thr Asn  Ile Gln Lys Lys Tyr  Tyr Arg Ala Ile Leu  Glu Lys Asn 
    1055                 1060                 1065             


Phe Ser  Phe Leu Ser Lys Gly  Ala Gly His Thr Asn  Met Pro Asn 
    1070                 1075                 1080             


Leu Leu  Asn Thr Met Met Glu  Leu Arg Lys Cys Cys  Asn His Pro 
    1085                 1090                 1095             


Tyr Leu  Ile Asn Gly Ala Glu  Glu Lys Ile Leu Thr  Glu Phe Arg 
    1100                 1105                 1110             


Glu Ala  Cys His Ile Ile Pro  His Asp Phe His Leu  Gln Ala Met 
    1115                 1120                 1125             


Val Arg  Ser Ala Gly Lys Leu  Val Leu Ile Asp Lys  Leu Leu Pro 
    1130                 1135                 1140             


Lys Leu  Lys Ala Gly Gly His  Lys Val Leu Ile Phe  Ser Gln Met 
    1145                 1150                 1155             


Val Arg  Cys Leu Asp Ile Leu  Glu Asp Tyr Leu Ile  Gln Arg Arg 
    1160                 1165                 1170             


Tyr Leu  Tyr Glu Arg Ile Asp  Gly Arg Val Arg Gly  Asn Leu Arg 
    1175                 1180                 1185             


Gln Ala  Ala Ile Asp Arg Phe  Ser Lys Pro Asp Ser  Asp Arg Phe 
    1190                 1195                 1200             


Val Phe  Leu Leu Cys Thr Arg  Ala Gly Gly Leu Gly  Ile Asn Leu 
    1205                 1210                 1215             


Thr Ala  Ala Asp Thr Cys Ile  Ile Phe Asp Ser Asp  Trp Asn Pro 
    1220                 1225                 1230             


Gln Asn  Asp Leu Gln Ala Gln  Ala Arg Cys His Arg  Ile Gly Gln 
    1235                 1240                 1245             


Ser Lys  Ala Val Lys Val Tyr  Arg Leu Ile Thr Arg  Asn Ser Tyr 
    1250                 1255                 1260             


Glu Arg  Glu Met Phe Asp Lys  Ala Ser Leu Lys Leu  Gly Leu Asp 
    1265                 1270                 1275             


Lys Ala  Val Leu Gln Ser Met  Ser Gly Arg Asp Gly  Asn Ile Thr 
    1280                 1285                 1290             


Gly Ile  Gln Gln Phe Ser Lys  Lys Glu Ile Glu Asp  Leu Leu Arg 
    1295                 1300                 1305             


Lys Gly  Ala Tyr Ala Ala Ile  Met Glu Glu Asp Asp  Glu Gly Ser 
    1310                 1315                 1320             


Lys Phe  Cys Glu Glu Asp Ile  Asp Gln Ile Leu Leu  Arg Arg Thr 
    1325                 1330                 1335             


Thr Thr  Ile Thr Ile Glu Ser  Glu Gly Lys Gly Ser  Thr Phe Ala 
    1340                 1345                 1350             


Lys Ala  Ser Phe Val Ala Ser  Glu Asn Arg Thr Asp  Ile Ser Leu 
    1355                 1360                 1365             


Asp Asp  Pro Asn Phe Trp Gln  Lys Trp Ala Lys Lys  Ala Asp Leu 
    1370                 1375                 1380             


Asp Met  Asp Leu Leu Asn Ser  Lys Asn Asn Leu Val  Ile Asp Thr 
    1385                 1390                 1395             


Pro Arg  Val Arg Lys Gln Thr  Arg His Phe Ser Thr  Leu Lys Asp 
    1400                 1405                 1410             


Asp Asp  Leu Val Glu Phe Ser  Asp Leu Glu Ser Glu  Asp Asp Glu 
    1415                 1420                 1425             


Arg Pro  Arg Ser Arg Arg His  Asp Arg His His Ala  Tyr Gly Arg 
    1430                 1435                 1440             


Thr Asp  Cys Phe Arg Val Glu  Lys His Leu Leu Val  Tyr Gly Trp 
    1445                 1450                 1455             


Gly Arg  Trp Arg Asp Ile Leu  Ser His Gly Arg Phe  Lys Arg Arg 
    1460                 1465                 1470             


Met Thr  Glu Arg Asp Val Glu  Thr Ile Cys Arg Ala  Ile Leu Val 
    1475                 1480                 1485             


Tyr Cys  Leu Leu His Tyr Arg  Gly Asp Glu Asn Ile  Lys Gly Phe 
    1490                 1495                 1500             


Ile Trp  Asp Leu Ile Ser Pro  Ala Glu Asn Gly Lys  Thr Lys Glu 
    1505                 1510                 1515             


Leu Gln  Asn His Ser Gly Leu  Ser Ile Pro Val Pro  Arg Gly Arg 
    1520                 1525                 1530             


Lys Gly  Lys Lys Val Lys Ser  Gln Ser Thr Phe Asp  Ile His Lys 
    1535                 1540                 1545             


Ala Asp  Trp Ile Arg Lys Tyr  Asn Pro Asp Thr Leu  Phe Gln Asp 
    1550                 1555                 1560             


Glu Ser  Tyr Lys Lys His Leu  Lys His Gln Cys Asn  Lys Val Leu 
    1565                 1570                 1575             


Leu Arg  Val Arg Met Leu Tyr  Tyr Leu Arg Gln Glu  Val Ile Gly 
    1580                 1585                 1590             


Asp Gln  Ala Glu Lys Val Leu  Gly Gly Ala Ile Ala  Ser Glu Ile 
    1595                 1600                 1605             


Asp Ile  Trp Phe Pro Val Val  Asp Gln Leu Glu Val  Pro Thr Thr 
    1610                 1615                 1620             


Trp Trp  Asp Ser Glu Ala Asp  Lys Ser Leu Leu Ile  Gly Val Phe 
    1625                 1630                 1635             


Lys His  Gly Tyr Glu Lys Tyr  Asn Thr Met Arg Ala  Asp Pro Ala 
    1640                 1645                 1650             


Leu Cys  Phe Leu Glu Lys Ala  Gly Arg Pro Asp Asp  Lys Ala Ile 
    1655                 1660                 1665             


Ala Ala  Glu His Arg Val Leu  Asp Asn Phe Ser Asp  Ile Val Glu 
    1670                 1675                 1680             


Gly Val  Asp Phe Asp Lys Asp  Cys Glu Asp Pro Glu  Tyr Lys Pro 
    1685                 1690                 1695             


Leu Gln  Gly Pro Pro Lys Asp  Gln Asp Asp Glu Gly  Asp Pro Leu 
    1700                 1705                 1710             


Met Met  Met Asp Glu Glu Ile  Ser Val Ile Asp Gly  Asp Glu Ala 
    1715                 1720                 1725             


Gln Val  Thr Gln Gln Pro Gly  His Leu Phe Trp Pro  Pro Gly Ser 
    1730                 1735                 1740             


Ala Leu  Thr Ala Arg Leu Arg  Arg Leu Val Thr Ala  Tyr Gln Arg 
    1745                 1750                 1755             


Ser Tyr  Lys Arg Glu Gln Met  Lys Ile Glu Ala Ala  Glu Arg Gly 
    1760                 1765                 1770             


Asp Arg  Arg Arg Arg Arg Cys  Glu Ala Ala Phe Lys  Leu Lys Glu 
    1775                 1780                 1785             


Ile Ala  Arg Arg Glu Lys Gln  Gln Arg Trp Thr Arg  Arg Glu Gln 
    1790                 1795                 1800             


Thr Asp  Phe Tyr Arg Val Val  Ser Thr Phe Gly Val  Glu Tyr Asp 
    1805                 1810                 1815             


Pro Asp  Thr Met Gln Phe His  Trp Asp Arg Phe Arg  Thr Phe Ala 
    1820                 1825                 1830             


Arg Leu  Asp Lys Lys Thr Asp  Glu Ser Leu Thr Lys  Tyr Phe His 
    1835                 1840                 1845             


Gly Phe  Val Ala Met Cys Arg  Gln Val Cys Arg Leu  Pro Pro Ala 
    1850                 1855                 1860             


Ala Gly  Asp Glu Pro Pro Asp  Pro Asn Leu Phe Ile  Glu Pro Ile 
    1865                 1870                 1875             


Thr Glu  Glu Arg Ala Ser Arg  Thr Leu Tyr Arg Ile  Glu Leu Leu 
    1880                 1885                 1890             


Arg Arg  Leu Arg Glu Gln Val  Leu Cys His Pro Leu  Leu Glu Asp 
    1895                 1900                 1905             


Arg Leu  Ala Leu Cys Gln Pro  Pro Gly Pro Glu Leu  Pro Lys Trp 
    1910                 1915                 1920             


Trp Glu  Pro Val Arg His Asp  Gly Glu Leu Leu Arg  Gly Ala Ala 
    1925                 1930                 1935             


Arg His  Gly Val Ser Gln Thr  Asp Cys Asn Ile Met  Gln Asp Pro 
    1940                 1945                 1950             


Asp Phe  Ser Phe Leu Ala Ala  Arg Met Asn Tyr Met  Gln Asn His 
    1955                 1960                 1965             


Gln Ala  Gly Ala Pro Ala Pro  Ser Leu Ser Arg Cys  Ser Thr Pro 
    1970                 1975                 1980             


Leu Leu  His Gln Gln Tyr Thr  Ser Arg Thr Ala Ser  Pro Leu Pro 
    1985                 1990                 1995             


Leu Arg  Pro Asp Ala Pro Val  Glu Lys Ser Pro Glu  Glu Thr Ala 
    2000                 2005                 2010             


Thr Gln  Val Pro Ser Leu Glu  Ser Leu Thr Leu Lys  Leu Glu His 
    2015                 2020                 2025             


Glu Val  Val Ala Arg Ser Arg  Pro Thr Pro Gln Asp  Tyr Glu Met 
    2030                 2035                 2040             


Arg Val  Ser Pro Ser Asp Thr  Thr Pro Leu Val Ser  Arg Ser Val 
    2045                 2050                 2055             


Pro Pro  Val Lys Leu Glu Asp  Glu Asp Asp Ser Asp  Ser Glu Leu 
    2060                 2065                 2070             


Asp Leu  Ser Lys Leu Ser Pro  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2075                 2080                 2085             


Ser Ser  Ser Ser Ser Ser Thr  Asp Glu Ser Glu Asp  Glu Lys Glu 
    2090                 2095                 2100             


Glu Lys  Leu Thr Asp Gln Ser  Arg Ser Lys Leu Tyr  Asp Glu Glu 
    2105                 2110                 2115             


Ser Leu  Leu Ser Leu Thr Met  Ser Gln Asp Gly Phe  Pro Asn Glu 
    2120                 2125                 2130             


Asp Gly  Glu Gln Met Thr Pro  Glu Leu Leu Leu Leu  Gln Glu Arg 
    2135                 2140                 2145             


Gln Arg  Ala Ser Glu Trp Pro  Lys Asp Arg Val Leu  Ile Asn Arg 
    2150                 2155                 2160             


Ile Asp  Leu Val Cys Gln Ala  Val Leu Ser Gly Lys  Trp Pro Ser 
    2165                 2170                 2175             


Ser Arg  Arg Ser Gln Glu Met  Val Thr Gly Gly Ile  Leu Gly Pro 
    2180                 2185                 2190             


Gly Asn  His Leu Leu Asp Ser  Pro Ser Leu Thr Pro  Gly Glu Tyr 
    2195                 2200                 2205             


Gly Asp  Ser Pro Val Pro Thr  Pro Arg Ser Ser Ser  Ala Ala Ser 
    2210                 2215                 2220             


Met Ala  Glu Glu Glu Ala Ser  Ala Val Ser Thr Ala  Ala Ala Gln 
    2225                 2230                 2235             


Phe Thr  Lys Leu Arg Arg Gly  Met Asp Glu Lys Glu  Phe Thr Val 
    2240                 2245                 2250             


Gln Ile  Lys Asp Glu Glu Gly  Leu Lys Leu Thr Phe  Gln Lys His 
    2255                 2260                 2265             


Lys Leu  Met Ala Asn Gly Val  Met Gly Asp Gly His  Pro Leu Phe 
    2270                 2275                 2280             


His Lys  Lys Lys Gly Asn Arg  Lys Lys Leu Val Glu  Leu Glu Val 
    2285                 2290                 2295             


Glu Cys  Met Glu Glu Pro Asn  His Leu Asp Val Asp  Leu Glu Thr 
    2300                 2305                 2310             


Arg Ile  Pro Val Ile Asn Lys  Val Asp Gly Thr Leu  Leu Val Gly 
    2315                 2320                 2325             


Glu Asp  Ala Pro Arg Arg Ala  Glu Leu Glu Met Trp  Leu Gln Gly 
    2330                 2335                 2340             


His Pro  Glu Phe Ala Val Asp  Pro Arg Phe Leu Ala  Tyr Met Glu 
    2345                 2350                 2355             


Asp Arg  Arg Lys Gln Lys Trp  Gln Arg Cys Lys Lys  Asn Asn Lys 
    2360                 2365                 2370             


Ala Glu  Leu Asn Cys Leu Gly  Met Glu Pro Val Gln  Thr Ala Asn 
    2375                 2380                 2385             


Ser Arg  Asn Gly Lys Lys Gly  His His Thr Glu Thr  Val Phe Asn 
    2390                 2395                 2400             


Arg Val  Leu Pro Gly Pro Ile  Ala Pro Glu Ser Ser  Lys Lys Arg 
    2405                 2410                 2415             


Ala Arg  Arg Met Arg Pro Asp  Leu Ser Lys Met Met  Ala Leu Met 
    2420                 2425                 2430             


Gln Gly  Gly Ser Thr Gly Ser  Leu Ser Leu His Asn  Thr Phe Gln 
    2435                 2440                 2445             


His Ser  Ser Ser Gly Leu Gln  Ser Val Ser Ser Leu  Gly His Ser 
    2450                 2455                 2460             


Ser Ala  Thr Ser Ala Ser Leu  Pro Phe Met Pro Phe  Val Met Gly 
    2465                 2470                 2475             


Gly Ala  Pro Ser Ser Pro His  Val Asp Ser Ser Thr  Met Leu His 
    2480                 2485                 2490             


His His  His His His Pro His  Pro His His His His  His His His 
    2495                 2500                 2505             


Pro Gly  Leu Arg Ala Pro Gly  Tyr Pro Ser Ser Pro  Val Thr Thr 
    2510                 2515                 2520             


Ala Ser  Gly Thr Thr Leu Arg  Leu Pro Pro Leu Gln  Pro Glu Glu 
    2525                 2530                 2535             


Asp Asp  Asp Glu Asp Glu Glu  Asp Asp Asp Asp Leu  Ser Gln Gly 
    2540                 2545                 2550             


Tyr Asp  Ser Ser Glu Arg Asp  Phe Ser Leu Ile Asp  Asp Pro Met 
    2555                 2560                 2565             


Met Pro  Ala Asn Ser Asp Ser  Ser Glu Asp Ala Asp  Asp 
    2570                 2575                 2580     


<210>  2118
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHDH__Homo_sapiens__NP_060867

<400>  2118

Met Trp Cys Leu Leu Arg Gly Leu Gly Arg Pro Gly Ala Leu Ala Arg 
1               5                   10                  15      


Gly Ala Leu Gly Gln Gln Gln Ser Leu Gly Ala Arg Ala Leu Ala Ser 
            20                  25                  30          


Ala Gly Ser Glu Ser Arg Asp Glu Tyr Ser Tyr Val Val Val Gly Ala 
        35                  40                  45              


Gly Ser Ala Gly Cys Val Leu Ala Gly Arg Leu Thr Glu Asp Pro Ala 
    50                  55                  60                  


Glu Arg Val Leu Leu Leu Glu Ala Gly Pro Lys Asp Val Leu Ala Gly 
65                  70                  75                  80  


Ser Lys Arg Leu Ser Trp Lys Ile His Met Pro Ala Ala Leu Val Ala 
                85                  90                  95      


Asn Leu Cys Asp Asp Arg Tyr Asn Trp Cys Tyr His Thr Glu Val Gln 
            100                 105                 110         


Arg Gly Leu Asp Gly Arg Val Leu Tyr Trp Pro Arg Gly Arg Val Trp 
        115                 120                 125             


Gly Gly Ser Ser Ser Leu Asn Ala Met Val Tyr Val Arg Gly His Ala 
    130                 135                 140                 


Glu Asp Tyr Glu Arg Trp Gln Arg Gln Gly Ala Arg Gly Trp Asp Tyr 
145                 150                 155                 160 


Ala His Cys Leu Pro Tyr Phe Arg Lys Ala Gln Gly His Glu Leu Gly 
                165                 170                 175     


Ala Ser Arg Tyr Arg Gly Ala Asp Gly Pro Leu Arg Val Ser Arg Gly 
            180                 185                 190         


Lys Thr Asn His Pro Leu His Cys Ala Phe Leu Glu Ala Thr Gln Gln 
        195                 200                 205             


Ala Gly Tyr Pro Leu Thr Glu Asp Met Asn Gly Phe Gln Gln Glu Gly 
    210                 215                 220                 


Phe Gly Trp Met Asp Met Thr Ile His Glu Gly Lys Arg Trp Ser Ala 
225                 230                 235                 240 


Ala Cys Ala Tyr Leu His Pro Ala Leu Ser Arg Thr Asn Leu Lys Ala 
                245                 250                 255     


Glu Ala Glu Thr Leu Val Ser Arg Val Leu Phe Glu Gly Thr Arg Ala 
            260                 265                 270         


Val Gly Val Glu Tyr Val Lys Asn Gly Gln Ser His Arg Ala Tyr Ala 
        275                 280                 285             


Ser Lys Glu Val Ile Leu Ser Gly Gly Ala Ile Asn Ser Pro Gln Leu 
    290                 295                 300                 


Leu Met Leu Ser Gly Ile Gly Asn Ala Asp Asp Leu Lys Lys Leu Gly 
305                 310                 315                 320 


Ile Pro Val Val Cys His Leu Pro Gly Val Gly Gln Asn Leu Gln Asp 
                325                 330                 335     


His Leu Glu Ile Tyr Ile Gln Gln Ala Cys Thr Arg Pro Ile Thr Leu 
            340                 345                 350         


His Ser Ala Gln Lys Pro Leu Arg Lys Val Cys Ile Gly Leu Glu Trp 
        355                 360                 365             


Leu Trp Lys Phe Thr Gly Glu Gly Ala Thr Ala His Leu Glu Thr Gly 
    370                 375                 380                 


Gly Phe Ile Arg Ser Gln Pro Gly Val Pro His Pro Asp Ile Gln Phe 
385                 390                 395                 400 


His Phe Leu Pro Ser Gln Val Ile Asp His Gly Arg Val Pro Thr Gln 
                405                 410                 415     


Gln Glu Ala Tyr Gln Val His Val Gly Pro Met Arg Gly Thr Ser Val 
            420                 425                 430         


Gly Trp Leu Lys Leu Arg Ser Ala Asn Pro Gln Asp His Pro Val Ile 
        435                 440                 445             


Gln Pro Asn Tyr Leu Ser Thr Glu Thr Asp Ile Glu Asp Phe Arg Leu 
    450                 455                 460                 


Cys Val Lys Leu Thr Arg Glu Ile Phe Ala Gln Glu Ala Leu Ala Pro 
465                 470                 475                 480 


Phe Arg Gly Lys Glu Leu Gln Pro Gly Ser His Ile Gln Ser Asp Lys 
                485                 490                 495     


Glu Ile Asp Ala Phe Val Arg Ala Lys Ala Asp Ser Ala Tyr His Pro 
            500                 505                 510         


Ser Cys Thr Cys Lys Met Gly Gln Pro Ser Asp Pro Thr Ala Val Val 
        515                 520                 525             


Asp Pro Gln Thr Arg Val Leu Gly Val Glu Asn Leu Arg Val Val Asp 
    530                 535                 540                 


Ala Ser Ile Met Pro Ser Met Val Ser Gly Asn Leu Asn Ala Pro Thr 
545                 550                 555                 560 


Ile Met Ile Ala Glu Lys Ala Ala Asp Ile Ile Lys Gly Gln Pro Ala 
                565                 570                 575     


Leu Trp Asp Lys Asp Val Pro Val Tyr Lys Pro Arg Thr Leu Ala Thr 
            580                 585                 590         


Gln Arg 
        


<210>  2119
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHEK1__Homo_sapiens__NP_001231775

<400>  2119

Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Thr Leu Gly 
1               5                   10                  15      


Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Thr Glu 
            20                  25                  30          


Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys 
        35                  40                  45              


Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His 
    50                  55                  60                  


Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln 
65                  70                  75                  80  


Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile 
                85                  90                  95      


Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His 
            100                 105                 110         


Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Thr His 
        115                 120                 125             


Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu 
    130                 135                 140                 


Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn Asn Arg 
145                 150                 155                 160 


Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val Ala Pro 
                165                 170                 175     


Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp 
            180                 185                 190         


Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu Pro Trp 
        195                 200                 205             


Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala 
225                 230                 235                 240 


Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Thr Ile 
                245                 250                 255     


Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly 
            260                 265                 270         


Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser Pro Ser 
        275                 280                 285             


Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn 
    290                 295                 300                 


Ser Ala Ser Ser Glu Glu Asn Val Lys Tyr Ser Ser Ser Gln Pro Glu 
305                 310                 315                 320 


Pro Arg Thr Gly Leu Ser Leu Trp Asp Thr Ser Pro Ser Tyr Ile Asp 
                325                 330                 335     


Lys Leu Val Gln Gly Ile Ser Phe Ser Gln Pro Thr Cys Pro Asp His 
            340                 345                 350         


Met Leu Leu Asn Ser Gln Leu Leu Gly Thr Pro Gly Ser Ser Gln Asn 
        355                 360                 365             


Pro Trp Gln Arg Leu Val Lys Arg Met Thr Arg Phe Phe Thr Lys Leu 
    370                 375                 380                 


Asp Ala Asp Lys Ser Tyr Gln Cys Leu Lys Glu Thr Cys Glu Lys Leu 
385                 390                 395                 400 


Gly Tyr Gln Trp Lys Lys Ser Cys Met Asn Gln Gly Asp Gly Leu Glu 
                405                 410                 415     


Phe Lys Arg His Phe Leu Lys Ile Lys Gly Lys Leu Ile Asp Ile Val 
            420                 425                 430         


Ser Ser Gln Lys Ile Trp Leu Pro Ala Thr 
        435                 440         


<210>  2120
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHEK2__Homo_sapiens__NP_001244316

<400>  2120

Met Ser Lys Thr Leu Gly Ser Gly Ala Cys Gly Glu Val Lys Leu Ala 
1               5                   10                  15      


Phe Glu Arg Lys Thr Cys Lys Lys Val Ala Ile Lys Ile Ile Ser Lys 
            20                  25                  30          


Arg Lys Phe Ala Ile Gly Ser Ala Arg Glu Ala Asp Pro Ala Leu Asn 
        35                  40                  45              


Val Glu Thr Glu Ile Glu Ile Leu Lys Lys Leu Asn His Pro Cys Ile 
    50                  55                  60                  


Ile Lys Ile Lys Asn Phe Phe Asp Ala Glu Asp Tyr Tyr Ile Val Leu 
65                  70                  75                  80  


Glu Leu Met Glu Gly Gly Glu Leu Phe Asp Lys Val Val Gly Asn Lys 
                85                  90                  95      


Arg Leu Lys Glu Ala Thr Cys Lys Leu Tyr Phe Tyr Gln Met Leu Leu 
            100                 105                 110         


Ala Val Gln Tyr Leu His Glu Asn Gly Ile Ile His Arg Asp Leu Lys 
        115                 120                 125             


Pro Glu Asn Val Leu Leu Ser Ser Gln Glu Glu Asp Cys Leu Ile Lys 
    130                 135                 140                 


Ile Thr Asp Phe Gly His Ser Lys Ile Leu Gly Glu Thr Ser Leu Met 
145                 150                 155                 160 


Arg Thr Leu Cys Gly Thr Pro Thr Tyr Leu Ala Pro Glu Val Leu Val 
                165                 170                 175     


Ser Val Gly Thr Ala Gly Tyr Asn Arg Ala Val Asp Cys Trp Ser Leu 
            180                 185                 190         


Gly Val Ile Leu Phe Ile Cys Leu Ser Gly Tyr Pro Pro Phe Ser Glu 
        195                 200                 205             


His Arg Thr Gln Val Ser Leu Lys Asp Gln Ile Thr Ser Gly Lys Tyr 
    210                 215                 220                 


Asn Phe Ile Pro Glu Val Trp Ala Glu Val Ser Glu Lys Ala Leu Asp 
225                 230                 235                 240 


Leu Val Lys Lys Leu Leu Val Val Asp Pro Lys Ala Arg Phe Thr Thr 
                245                 250                 255     


Glu Glu Ala Leu Arg His Pro Trp Leu Gln Asp Glu Asp Met Lys Arg 
            260                 265                 270         


Lys Phe Gln Asp Leu Leu Ser Glu Glu Asn Glu Ser Thr Ala Leu Pro 
        275                 280                 285             


Gln Val Leu Ala Gln Pro Ser Thr Ser Arg Lys Arg Pro Arg Glu Gly 
    290                 295                 300                 


Glu Ala Glu Gly Ala Glu Thr Thr Lys Arg Pro Ala Val Cys Ala Ala 
305                 310                 315                 320 


Val Leu 
        


<210>  2121
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHERP__Homo_sapiens__NP_006378

<400>  2121

Met Glu Met Pro Leu Pro Pro Asp Asp Gln Glu Leu Arg Asn Val Ile 
1               5                   10                  15      


Asp Lys Leu Ala Gln Phe Val Ala Arg Asn Gly Pro Glu Phe Glu Lys 
            20                  25                  30          


Met Thr Met Glu Lys Gln Lys Asp Asn Pro Lys Phe Ser Phe Leu Phe 
        35                  40                  45              


Gly Gly Glu Phe Tyr Ser Tyr Tyr Lys Cys Lys Leu Ala Leu Glu Gln 
    50                  55                  60                  


Gln Gln Leu Ile Cys Lys Gln Gln Thr Pro Glu Leu Glu Pro Ala Ala 
65                  70                  75                  80  


Thr Met Pro Pro Leu Pro Gln Pro Pro Leu Ala Pro Ala Ala Pro Ile 
                85                  90                  95      


Pro Pro Ala Gln Gly Ala Pro Ser Met Asp Glu Leu Ile Gln Gln Ser 
            100                 105                 110         


Gln Trp Asn Leu Gln Gln Gln Glu Gln His Leu Leu Ala Leu Arg Gln 
        115                 120                 125             


Glu Gln Val Thr Ala Ala Val Ala His Ala Val Glu Gln Gln Met Gln 
    130                 135                 140                 


Lys Leu Leu Glu Glu Thr Gln Leu Asp Met Asn Glu Phe Asp Asn Leu 
145                 150                 155                 160 


Leu Gln Pro Ile Ile Asp Thr Cys Thr Lys Asp Ala Ile Ser Ala Gly 
                165                 170                 175     


Lys Asn Trp Met Phe Ser Asn Ala Lys Ser Pro Pro His Cys Glu Leu 
            180                 185                 190         


Met Ala Gly His Leu Arg Asn Arg Ile Thr Ala Asp Gly Ala His Phe 
        195                 200                 205             


Glu Leu Arg Leu His Leu Ile Tyr Leu Ile Asn Asp Val Leu His His 
    210                 215                 220                 


Cys Gln Arg Lys Gln Ala Arg Glu Leu Leu Ala Ala Leu Gln Lys Val 
225                 230                 235                 240 


Val Val Pro Ile Tyr Cys Thr Ser Phe Leu Ala Val Glu Glu Asp Lys 
                245                 250                 255     


Gln Gln Lys Ile Ala Arg Leu Leu Gln Leu Trp Glu Lys Asn Gly Tyr 
            260                 265                 270         


Phe Asp Asp Ser Ile Ile Gln Gln Leu Gln Ser Pro Ala Leu Gly Leu 
        275                 280                 285             


Gly Gln Tyr Gln Ala Thr Leu Ile Asn Glu Tyr Ser Ser Val Val Gln 
    290                 295                 300                 


Pro Val Gln Leu Ala Phe Gln Gln Gln Ile Gln Thr Leu Lys Thr Gln 
305                 310                 315                 320 


His Glu Glu Phe Val Thr Ser Leu Ala Gln Gln Gln Gln Gln Gln Gln 
                325                 330                 335     


Gln Gln Gln Gln Gln Leu Gln Met Pro Gln Met Glu Ala Glu Val Lys 
            340                 345                 350         


Ala Thr Pro Pro Pro Pro Ala Pro Pro Pro Ala Pro Ala Pro Ala Pro 
        355                 360                 365             


Ala Ile Pro Pro Thr Thr Gln Pro Asp Asp Ser Lys Pro Pro Ile Gln 
    370                 375                 380                 


Met Pro Gly Ser Ser Glu Tyr Glu Ala Pro Gly Gly Val Gln Asp Pro 
385                 390                 395                 400 


Ala Ala Ala Gly Pro Arg Gly Pro Gly Pro His Asp Gln Ile Pro Pro 
                405                 410                 415     


Asn Lys Pro Pro Trp Phe Asp Gln Pro His Pro Val Ala Pro Trp Gly 
            420                 425                 430         


Gln Gln Gln Pro Pro Glu Gln Pro Pro Tyr Pro His His Gln Gly Gly 
        435                 440                 445             


Pro Pro His Cys Pro Pro Trp Asn Asn Ser His Glu Gly Met Trp Gly 
    450                 455                 460                 


Glu Gln Arg Gly Asp Pro Gly Trp Asn Gly Gln Arg Asp Ala Pro Trp 
465                 470                 475                 480 


Asn Asn Gln Pro Asp Ala Ala Trp Asn Ser Gln Phe Glu Gly Pro Trp 
                485                 490                 495     


Asn Ser Gln His Glu Gln Pro Pro Trp Gly Gly Gly Gln Arg Glu Pro 
            500                 505                 510         


Pro Phe Arg Met Gln Arg Pro Pro His Phe Arg Gly Pro Phe Pro Pro 
        515                 520                 525             


His Gln Gln His Pro Gln Phe Asn Gln Pro Pro His Pro His Asn Phe 
    530                 535                 540                 


Asn Arg Phe Pro Pro Arg Phe Met Gln Asp Asp Phe Pro Pro Arg His 
545                 550                 555                 560 


Pro Phe Glu Arg Pro Pro Tyr Pro His Arg Phe Asp Tyr Pro Gln Gly 
                565                 570                 575     


Asp Phe Pro Ala Glu Met Gly Pro Pro His His His Pro Gly His Arg 
            580                 585                 590         


Met Pro His Pro Gly Ile Asn Glu His Pro Pro Trp Ala Gly Pro Gln 
        595                 600                 605             


His Pro Asp Phe Gly Pro Pro Pro His Gly Phe Asn Gly Gln Pro Pro 
    610                 615                 620                 


His Met Arg Arg Gln Gly Pro Pro His Ile Asn His Asp Asp Pro Ser 
625                 630                 635                 640 


Leu Val Pro Asn Val Pro Tyr Phe Asp Leu Pro Ala Gly Leu Met Ala 
                645                 650                 655     


Pro Leu Val Lys Leu Glu Asp His Glu Tyr Lys Pro Leu Asp Pro Lys 
            660                 665                 670         


Asp Ile Arg Leu Pro Pro Pro Met Pro Pro Ser Glu Arg Leu Leu Ala 
        675                 680                 685             


Ala Val Glu Ala Phe Tyr Ser Pro Pro Ser His Asp Arg Pro Arg Asn 
    690                 695                 700                 


Ser Glu Gly Trp Glu Gln Asn Gly Leu Tyr Glu Phe Phe Arg Ala Lys 
705                 710                 715                 720 


Met Arg Ala Arg Arg Arg Lys Gly Gln Glu Lys Arg Asn Ser Gly Pro 
                725                 730                 735     


Ser Arg Ser Arg Ser Arg Ser Lys Ser Arg Gly Arg Ser Ser Ser Arg 
            740                 745                 750         


Ser Asn Ser Arg Ser Ser Lys Ser Ser Gly Ser Tyr Ser Arg Ser Arg 
        755                 760                 765             


Ser Arg Ser Cys Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Ser Arg 
    770                 775                 780                 


Ser Arg Ser Arg Ser Ser Arg Ser Arg Ser Arg Ser Gln Ser Arg Ser 
785                 790                 795                 800 


Arg Ser Lys Ser Tyr Ser Pro Gly Arg Arg Arg Arg Ser Arg Ser Arg 
                805                 810                 815     


Ser Pro Thr Pro Pro Ser Ser Ala Gly Leu Gly Ser Asn Ser Ala Pro 
            820                 825                 830         


Pro Ile Pro Asp Ser Arg Leu Gly Glu Glu Asn Lys Gly His Gln Met 
        835                 840                 845             


Leu Val Lys Met Gly Trp Ser Gly Ser Gly Gly Leu Gly Ala Lys Glu 
    850                 855                 860                 


Gln Gly Ile Gln Asp Pro Ile Lys Gly Gly Asp Val Arg Asp Lys Trp 
865                 870                 875                 880 


Asp Gln Tyr Lys Gly Val Gly Val Ala Leu Asp Asp Pro Tyr Glu Asn 
                885                 890                 895     


Tyr Arg Arg Asn Lys Ser Tyr Ser Phe Ile Ala Arg Met Lys Ala Arg 
            900                 905                 910         


Asp Glu Cys Lys 
        915     


<210>  2122
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHFR__Homo_sapiens__NP_001154816

<400>  2122

Met Glu Arg Pro Glu Glu Gly Lys Gln Ser Pro Pro Pro Gln Pro Trp 
1               5                   10                  15      


Gly Arg Leu Leu Arg Leu Gly Ala Glu Glu Gly Glu Pro His Val Leu 
            20                  25                  30          


Leu Arg Lys Arg Glu Trp Thr Ile Gly Arg Arg Arg Gly Cys Asp Leu 
        35                  40                  45              


Ser Phe Pro Ser Asn Lys Leu Val Ser Gly Asp His Cys Arg Ile Val 
    50                  55                  60                  


Val Asp Glu Lys Ser Gly Gln Val Thr Leu Glu Asp Thr Ser Thr Ser 
65                  70                  75                  80  


Gly Thr Val Ile Asn Lys Leu Lys Val Val Lys Lys Gln Thr Cys Pro 
                85                  90                  95      


Leu Gln Thr Gly Asp Val Ile Tyr Leu Val Tyr Arg Lys Asn Glu Pro 
            100                 105                 110         


Glu His Asn Val Ala Tyr Leu Tyr Glu Ser Leu Ser Glu Lys Gln Gly 
        115                 120                 125             


Met Thr Gln Glu Ser Phe Glu Ala Asn Lys Glu Asn Val Phe His Gly 
    130                 135                 140                 


Thr Lys Asp Thr Ser Gly Ala Gly Ala Gly Arg Gly Ala Asp Pro Arg 
145                 150                 155                 160 


Val Pro Pro Ser Ser Pro Ala Thr Gln Val Cys Phe Glu Glu Pro Gln 
                165                 170                 175     


Pro Ser Thr Ser Thr Ser Asp Leu Phe Pro Thr Ala Ser Ala Ser Ser 
            180                 185                 190         


Thr Glu Pro Ser Pro Ala Gly Arg Glu Arg Ser Ser Ser Cys Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ile Ser Pro Lys Gly Ser Gly Pro Ser Val Ala Ser 
    210                 215                 220                 


Asp Glu Val Ser Ser Phe Ala Ser Ala Leu Pro Asp Arg Lys Thr Ala 
225                 230                 235                 240 


Ser Phe Ser Ser Leu Glu Pro Gln Asp Gln Glu Asp Leu Glu Pro Val 
                245                 250                 255     


Lys Lys Lys Met Arg Gly Asp Gly Asp Leu Asp Leu Asn Gly Gln Leu 
            260                 265                 270         


Leu Val Ala Gln Pro Arg Arg Asn Ala Gln Thr Val His Glu Asp Val 
        275                 280                 285             


Arg Ala Ala Ala Gly Lys Pro Asp Lys Met Glu Glu Thr Leu Thr Cys 
    290                 295                 300                 


Ile Ile Cys Gln Asp Leu Leu His Asp Cys Val Ser Leu Gln Pro Cys 
305                 310                 315                 320 


Met His Thr Phe Cys Ala Ala Cys Tyr Ser Gly Trp Met Glu Arg Ser 
                325                 330                 335     


Ser Leu Cys Pro Thr Cys Arg Cys Pro Val Glu Arg Ile Cys Lys Asn 
            340                 345                 350         


His Ile Leu Asn Asn Leu Val Glu Ala Tyr Leu Ile Gln His Pro Asp 
        355                 360                 365             


Lys Ser Arg Ser Glu Glu Asp Val Gln Ser Met Asp Ala Arg Asn Lys 
    370                 375                 380                 


Ile Thr Gln Asp Met Leu Gln Pro Lys Val Arg Arg Ser Phe Ser Asp 
385                 390                 395                 400 


Glu Glu Gly Ser Ser Glu Asp Leu Leu Glu Leu Ser Asp Val Asp Ser 
                405                 410                 415     


Glu Ser Ser Asp Ile Ser Gln Pro Tyr Val Val Cys Arg Gln Cys Pro 
            420                 425                 430         


Glu Tyr Arg Arg Gln Ala Ala Gln Pro Pro His Cys Pro Ala Pro Glu 
        435                 440                 445             


Gly Glu Pro Gly Ala Pro Gln Ala Leu Gly Asp Ala Pro Ser Thr Ser 
    450                 455                 460                 


Val Ser Leu Thr Thr Ala Val Gln Asp Tyr Val Cys Pro Leu Gln Gly 
465                 470                 475                 480 


Ser His Ala Leu Cys Thr Cys Cys Phe Gln Pro Met Pro Asp Arg Arg 
                485                 490                 495     


Ala Glu Arg Glu Gln Asp Pro Arg Val Ala Pro Gln Gln Cys Ala Val 
            500                 505                 510         


Cys Leu Gln Pro Phe Cys His Leu Tyr Trp Gly Cys Thr Arg Thr Gly 
        515                 520                 525             


Cys Tyr Gly Cys Leu Ala Pro Phe Cys Glu Leu Asn Leu Gly Asp Lys 
    530                 535                 540                 


Cys Leu Asp Gly Val Leu Asn Asn Asn Ser Tyr Glu Ser Asp Ile Leu 
545                 550                 555                 560 


Lys Asn Tyr Leu Ala Thr Arg Gly Leu Thr Trp Lys Asn Met Leu Thr 
                565                 570                 575     


Glu Ser Leu Val Ala Leu Gln Arg Gly Val Phe Leu Leu Ser Asp Tyr 
            580                 585                 590         


Arg Val Thr Gly Asp Thr Val Leu Cys Tyr Cys Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Arg Glu Leu Thr Tyr Gln Tyr Arg Gln Asn Ile Pro Ala Ser Glu 
    610                 615                 620                 


Leu Pro Val Ala Val Thr Ser Arg Pro Asp Cys Tyr Trp Gly Arg Asn 
625                 630                 635                 640 


Cys Arg Thr Gln Val Lys Ala His His Ala Met Lys Phe Asn His Ile 
                645                 650                 655     


Cys Glu Gln Thr Arg Phe Lys Asn 
            660                 


<210>  2123
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHGA__Homo_sapiens__NP_001288619

<400>  2123

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Gly Arg Ser Glu Ala Leu Ala Val Asp Gly 
        115                 120                 125             


Ala Gly Lys Pro Gly Ala Glu Glu Ala Gln Asp Pro Glu Gly Lys Gly 
    130                 135                 140                 


Glu Gln Glu His Ser Gln Gln Lys Glu Glu Glu Glu Glu Met Ala Val 
145                 150                 155                 160 


Val Pro Gln Gly Leu Phe Arg Gly Gly Lys Ser Gly Glu Leu Glu Gln 
                165                 170                 175     


Glu Glu Glu Arg Leu Ser Lys Glu Trp Glu Asp Ser Lys Arg Trp Ser 
            180                 185                 190         


Lys Met Asp Gln Leu Ala Lys Glu Leu Thr Ala Glu Lys Arg Leu Glu 
        195                 200                 205             


Gly Gln Glu Glu Glu Glu Asp Asn Arg Asp Ser Ser Met Lys Leu Ser 
    210                 215                 220                 


Phe Arg Ala Arg Ala Tyr Gly Phe Arg Gly Pro Gly Pro Gln Leu Arg 
225                 230                 235                 240 


Arg Gly Trp Arg Pro Ser Ser Arg Glu Asp Ser Leu Glu Ala Gly Leu 
                245                 250                 255     


Pro Leu Gln Val Arg Gly Tyr Pro Glu Glu Lys Lys Glu Glu Glu Gly 
            260                 265                 270         


Ser Ala Asn Arg Arg Pro Glu Asp Gln Glu Leu Glu Ser Leu Ser Ala 
        275                 280                 285             


Ile Glu Ala Glu Leu Glu Lys Val Ala His Gln Leu Gln Ala Leu Arg 
    290                 295                 300                 


Arg Gly 
305     


<210>  2124
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHGB__Homo_sapiens__NP_001810

<400>  2124

Met Gln Pro Thr Leu Leu Leu Ser Leu Leu Gly Ala Val Gly Leu Ala 
1               5                   10                  15      


Ala Val Asn Ser Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met 
            20                  25                  30          


Val Thr Arg Cys Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser 
        35                  40                  45              


Ser Ala Pro Pro Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser 
    50                  55                  60                  


Arg Lys Asp Val Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys 
65                  70                  75                  80  


Phe Glu Val Arg Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His 
                85                  90                  95      


Glu Ser Ser Ser Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile 
            100                 105                 110         


Gln Gly Pro Thr Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly 
        115                 120                 125             


His Ser Arg Glu Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser 
    130                 135                 140                 


Asp Ser Gln Val Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Glu Asp Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly 
                165                 170                 175     


Glu Arg Gly Glu Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly 
            180                 185                 190         


Glu Thr Gln Asn Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile 
        195                 200                 205             


Lys Lys Glu Glu Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His 
    210                 215                 220                 


Ser Gln Glu Lys Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly 
225                 230                 235                 240 


Glu Glu Thr Gly Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln 
                245                 250                 255     


Pro Arg Ser Gln Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser 
            260                 265                 270         


Glu Val Asp Lys Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser 
        275                 280                 285             


Arg Pro Asp Arg Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys 
    290                 295                 300                 


Gly His Pro Gln Glu Glu Ser Glu Glu Ser Asn Val Ser Met Ala Ser 
305                 310                 315                 320 


Leu Gly Glu Lys Arg Asp His His Ser Thr His Tyr Arg Ala Ser Glu 
                325                 330                 335     


Glu Glu Pro Glu Tyr Gly Glu Glu Ile Lys Gly Tyr Pro Gly Val Gln 
            340                 345                 350         


Ala Pro Glu Asp Leu Glu Trp Glu Arg Tyr Arg Gly Arg Gly Ser Glu 
        355                 360                 365             


Glu Tyr Arg Ala Pro Arg Pro Gln Ser Glu Glu Ser Trp Asp Glu Glu 
    370                 375                 380                 


Asp Lys Arg Asn Tyr Pro Ser Leu Glu Leu Asp Lys Met Ala His Gly 
385                 390                 395                 400 


Tyr Gly Glu Glu Ser Glu Glu Glu Arg Gly Leu Glu Pro Gly Lys Gly 
                405                 410                 415     


Arg His His Arg Gly Arg Gly Gly Glu Pro Arg Ala Tyr Phe Met Ser 
            420                 425                 430         


Asp Thr Arg Glu Glu Lys Arg Phe Leu Gly Glu Gly His His Arg Val 
        435                 440                 445             


Gln Glu Asn Gln Met Asp Lys Ala Arg Arg His Pro Gln Gly Ala Trp 
    450                 455                 460                 


Lys Glu Leu Asp Arg Asn Tyr Leu Asn Tyr Gly Glu Glu Gly Ala Pro 
465                 470                 475                 480 


Gly Lys Trp Gln Gln Gln Gly Asp Leu Gln Asp Thr Lys Glu Asn Arg 
                485                 490                 495     


Glu Glu Ala Arg Phe Gln Asp Lys Gln Tyr Ser Ser His His Thr Ala 
            500                 505                 510         


Glu Lys Arg Lys Arg Leu Gly Glu Leu Phe Asn Pro Tyr Tyr Asp Pro 
        515                 520                 525             


Leu Gln Trp Lys Ser Ser His Phe Glu Arg Arg Asp Asn Met Asn Asp 
    530                 535                 540                 


Asn Phe Leu Glu Gly Glu Glu Glu Asn Glu Leu Thr Leu Asn Glu Lys 
545                 550                 555                 560 


Asn Phe Phe Pro Glu Tyr Asn Tyr Asp Trp Trp Glu Lys Lys Pro Phe 
                565                 570                 575     


Ser Glu Asp Val Asn Trp Gly Tyr Glu Lys Arg Asn Leu Ala Arg Val 
            580                 585                 590         


Pro Lys Leu Asp Leu Lys Arg Gln Tyr Asp Arg Val Ala Gln Leu Asp 
        595                 600                 605             


Gln Leu Leu His Tyr Arg Lys Lys Ser Ala Glu Phe Pro Asp Phe Tyr 
    610                 615                 620                 


Asp Ser Glu Glu Pro Val Ser Thr His Gln Glu Ala Glu Asn Glu Lys 
625                 630                 635                 640 


Asp Arg Ala Asp Gln Thr Val Leu Thr Glu Asp Glu Lys Lys Glu Leu 
                645                 650                 655     


Glu Asn Leu Ala Ala Met Asp Leu Glu Leu Gln Lys Ile Ala Glu Lys 
            660                 665                 670         


Phe Ser Gln Arg Gly 
        675         


<210>  2125
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHI3L1__Homo_sapiens__XP_011507410

<400>  2125

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Ala Asp Phe Gly Pro Arg Phe 
            100                 105                 110         


Ser Lys Ile Ala Ser Asn Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser 
        115                 120                 125             


Val Pro Pro Phe Leu Arg Thr His Gly Phe Asp Gly Leu Asp Leu Ala 
    130                 135                 140                 


Trp Leu Tyr Pro Gly Arg Arg Asp Lys Gln His Phe Thr Thr Leu Ile 
145                 150                 155                 160 


Lys Glu Met Lys Ala Glu Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys 
                165                 170                 175     


Gln Leu Leu Leu Ser Ala Ala Leu Ser Ala Gly Lys Val Thr Ile Asp 
            180                 185                 190         


Ser Ser Tyr Asp Ile Ala Lys Ile Ser Gln His Leu Asp Phe Ile Ser 
        195                 200                 205             


Ile Met Thr Tyr Asp Phe His Gly Ala Trp Arg Gly Thr Thr Gly His 
    210                 215                 220                 


His Ser Pro Leu Phe Arg Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe 
225                 230                 235                 240 


Ser Asn Thr Ile Cys Asp Phe Leu Arg Gly Ala Thr Val His Arg Ile 
                245                 250                 255     


Leu Gly Gln Gln Val Pro Tyr Ala Thr Lys Gly Asn Gln Trp Val Gly 
            260                 265                 270         


Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys Val Gln Tyr Leu Lys Asp 
        275                 280                 285             


Arg Gln Leu Ala Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe 
    290                 295                 300                 


Gln Gly Ser Phe Cys Gly Gln Asp Leu Arg Phe Pro Leu Thr Asn Ala 
305                 310                 315                 320 


Ile Lys Asp Ala Leu Ala Ala Thr 
                325             


<210>  2126
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIC1__Homo_sapiens__NP_001034929

<400>  2126

Met Ser Ile Leu Leu Pro Asn Met Ala Glu Phe Asp Thr Ile Ser Glu 
1               5                   10                  15      


Leu Glu Glu Glu Glu Glu Glu Glu Ala Ala Thr Ser Ser Ser Ser Pro 
            20                  25                  30          


Ser Ser Ser Ser Ser Val Ser Gly Pro Asp Asp Asp Glu Glu Asp Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    50                  55                  60                  


Glu Glu Glu Glu Ala Pro Pro Pro Pro Arg Val Val Ser Glu Glu His 
65                  70                  75                  80  


Leu Arg Arg Tyr Ala Pro Asp Pro Val Leu Val Arg Gly Ala Gly His 
                85                  90                  95      


Ile Thr Val Phe Gly Leu Ser Asn Lys Phe Asp Thr Glu Phe Pro Ser 
            100                 105                 110         


Val Leu Thr Gly Lys Val Ala Pro Glu Glu Phe Lys Thr Ser Ile Gly 
        115                 120                 125             


Arg Val Asn Ala Cys Leu Lys Lys Ala Leu Pro Val Asn Val Lys Trp 
    130                 135                 140                 


Leu Leu Cys Gly Cys Leu Cys Cys Cys Cys Thr Leu Gly Cys Ser Leu 
145                 150                 155                 160 


Trp Pro Val Ile Cys Leu Asn Lys Arg Thr Arg Arg Ser Ile Gln Lys 
                165                 170                 175     


Leu Ile Glu Trp Glu Asn Asn Arg Leu Tyr His Lys Leu Ala Leu His 
            180                 185                 190         


Trp Lys Leu Thr Lys Arg Lys Cys Glu Thr Ser Asn Met Met Glu Tyr 
        195                 200                 205             


Val Ile Leu Ile Glu Phe Leu Pro Lys Tyr Pro Ile Phe Arg Pro Asp 
    210                 215                 220                 


<210>  2127
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIC2__Homo_sapiens__NP_036242

<400>  2127

Met Ala Asp Phe Asp Glu Ile Tyr Glu Glu Glu Glu Asp Glu Glu Arg 
1               5                   10                  15      


Ala Leu Glu Glu Gln Leu Leu Lys Tyr Ser Pro Asp Pro Val Val Val 
            20                  25                  30          


Arg Gly Ser Gly His Val Thr Val Phe Gly Leu Ser Asn Lys Phe Glu 
        35                  40                  45              


Ser Glu Phe Pro Ser Ser Leu Thr Gly Lys Val Ala Pro Glu Glu Phe 
    50                  55                  60                  


Lys Ala Ser Ile Asn Arg Val Asn Ser Cys Leu Lys Lys Asn Leu Pro 
65                  70                  75                  80  


Val Asn Val Arg Trp Leu Leu Cys Gly Cys Leu Cys Cys Cys Cys Thr 
                85                  90                  95      


Leu Gly Cys Ser Met Trp Pro Val Ile Cys Leu Ser Lys Arg Thr Arg 
            100                 105                 110         


Arg Ser Ile Glu Lys Leu Leu Glu Trp Glu Asn Asn Arg Leu Tyr His 
        115                 120                 125             


Lys Leu Cys Leu His Trp Arg Leu Ser Lys Arg Lys Cys Glu Thr Asn 
    130                 135                 140                 


Asn Met Met Glu Tyr Val Ile Leu Ile Glu Phe Leu Pro Lys Thr Pro 
145                 150                 155                 160 


Ile Phe Arg Pro Asp 
                165 


<210>  2128
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIT1__Homo_sapiens__NP_001243054

<400>  2128

Met Val Arg Ser Val Ala Trp Ala Gly Phe Met Val Leu Leu Met Ile 
1               5                   10                  15      


Pro Trp Gly Ser Ala Ala Lys Leu Val Cys Tyr Phe Thr Asn Trp Ala 
            20                  25                  30          


Gln Tyr Arg Gln Gly Glu Ala Arg Phe Leu Pro Lys Asp Leu Asp Pro 
        35                  40                  45              


Ser Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Thr Asn His 
    50                  55                  60                  


Gln Leu Ser Thr Thr Glu Trp Asn Asp Glu Thr Leu Tyr Gln Glu Phe 
65                  70                  75                  80  


Asn Gly Leu Lys Lys Met Phe Thr Asp Met Val Ala Thr Ala Asn Asn 
                85                  90                  95      


Arg Gln Thr Phe Val Asn Ser Ala Ile Arg Phe Leu Arg Lys Tyr Ser 
            100                 105                 110         


Phe Asp Gly Leu Asp Leu Asp Trp Glu Tyr Pro Gly Ser Gln Gly Ser 
        115                 120                 125             


Pro Ala Val Asp Lys Glu Arg Phe Thr Thr Leu Val Gln Asp Leu Ala 
    130                 135                 140                 


Asn Ala Phe Gln Gln Glu Ala Gln Thr Ser Gly Lys Glu Arg Leu Leu 
145                 150                 155                 160 


Leu Ser Ala Ala Val Pro Ala Gly Gln Thr Tyr Val Asp Ala Gly Tyr 
                165                 170                 175     


Glu Val Asp Lys Ile Ala Gln Asn Leu Asp Phe Val Asn Leu Met Ala 
            180                 185                 190         


Tyr Asp Phe His Gly Ser Trp Glu Lys Val Thr Gly His Asn Ser Pro 
        195                 200                 205             


Leu Tyr Lys Arg Gln Glu Glu Ser Gly Ala Ala Ala Ser Leu Asn Val 
    210                 215                 220                 


Asp Ala Ala Val Gln Gln Trp Leu Gln Lys Gly Thr Pro Ala Ser Lys 
225                 230                 235                 240 


Leu Ile Leu Gly Met Pro Thr Tyr Gly Arg Ser Phe Thr Leu Ala Ser 
                245                 250                 255     


Ser Ser Asp Thr Arg Val Gly Ala Pro Ala Thr Gly Ser Gly Thr Pro 
            260                 265                 270         


Gly Pro Phe Thr Lys Glu Gly Gly Met Leu Ala Tyr Tyr Glu Val Cys 
        275                 280                 285             


Ser Trp Lys Gly Ala Thr Lys Gln Arg Ile Gln Asp Gln Lys Val Pro 
    290                 295                 300                 


Tyr Ile Phe Arg Asp Asn Gln Trp Val Gly Phe Asp Asp Val Glu Ser 
305                 310                 315                 320 


Phe Lys Thr Lys Val Ser Tyr Leu Lys Gln Lys Gly Leu Gly Gly Ala 
                325                 330                 335     


Met Val Trp Ala Leu Asp Leu Asp Asp Phe Ala Gly Phe Ser Cys Asn 
            340                 345                 350         


Gln Gly Arg Tyr Pro Leu Ile Gln Thr Leu Arg Gln Glu Leu Ser Leu 
        355                 360                 365             


Pro Tyr Leu Pro Ser Gly Thr Pro Glu Leu Glu Val Pro Lys Pro Gly 
    370                 375                 380                 


Gln Pro Ser Glu Pro Glu His Gly Pro Ser Pro Gly Gln Asp Thr Phe 
385                 390                 395                 400 


Cys Gln Gly Lys Ala Asp Gly Leu Tyr Pro Asn Pro Arg Glu Arg Ser 
                405                 410                 415     


Ser Phe Tyr Ser Cys Ala Ala Gly Arg Leu Phe Gln Gln Ser Cys Pro 
            420                 425                 430         


Thr Gly Leu Val Phe Ser Asn Ser Cys Lys Cys Cys Thr Trp Asn 
        435                 440                 445         


<210>  2129
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHKA__Homo_sapiens__NP_997634

<400>  2129

Met Lys Thr Lys Phe Cys Thr Gly Gly Glu Ala Glu Pro Ser Pro Leu 
1               5                   10                  15      


Gly Leu Leu Leu Ser Cys Gly Ser Gly Ser Ala Ala Pro Ala Pro Gly 
            20                  25                  30          


Val Gly Gln Gln Arg Asp Ala Ala Ser Asp Leu Glu Ser Lys Gln Leu 
        35                  40                  45              


Gly Gly Gln Gln Pro Pro Leu Ala Leu Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Leu Pro Leu Pro Leu Pro Gln Pro Pro Pro Pro Gln Pro Pro Ala Asp 
65                  70                  75                  80  


Glu Gln Pro Glu Pro Arg Thr Arg Arg Arg Ala Tyr Leu Trp Cys Lys 
                85                  90                  95      


Glu Phe Leu Pro Gly Ala Trp Arg Gly Leu Arg Glu Asp Glu Phe His 
            100                 105                 110         


Ile Ser Val Ile Arg Gly Gly Leu Ser Asn Met Leu Phe Gln Cys Ser 
        115                 120                 125             


Leu Pro Asp Thr Thr Ala Thr Leu Gly Asp Glu Pro Arg Lys Val Leu 
    130                 135                 140                 


Leu Arg Leu Tyr Gly Ala Ile Leu Gln Met Gly Ala Glu Ala Met Val 
145                 150                 155                 160 


Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu Arg Ser Leu Gly Pro 
                165                 170                 175     


Lys Leu Tyr Gly Ile Phe Pro Gln Gly Arg Leu Glu Gln Phe Ile Pro 
            180                 185                 190         


Ser Arg Arg Leu Asp Thr Glu Glu Leu Ser Leu Pro Asp Ile Ser Ala 
        195                 200                 205             


Glu Ile Ala Glu Lys Met Ala Thr Phe His Gly Met Lys Met Pro Phe 
    210                 215                 220                 


Asn Lys Glu Pro Lys Trp Leu Phe Gly Thr Met Glu Lys Tyr Leu Lys 
225                 230                 235                 240 


Glu Val Leu Arg Ile Lys Phe Thr Glu Glu Ser Arg Ile Lys Lys Leu 
                245                 250                 255     


His Lys Leu Leu Ser Tyr Asn Leu Pro Leu Glu Leu Glu Asn Leu Arg 
            260                 265                 270         


Ser Leu Leu Glu Ser Thr Pro Ser Pro Val Val Phe Cys His Asn Asp 
        275                 280                 285             


Cys Gln Glu Gly Asn Ile Leu Leu Leu Glu Gly Arg Glu Asn Ser Glu 
    290                 295                 300                 


Lys Gln Lys Leu Met Leu Ile Asp Phe Glu Tyr Ser Ser Tyr Asn Tyr 
305                 310                 315                 320 


Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Met Tyr Asp Tyr 
                325                 330                 335     


Ser Tyr Glu Lys Tyr Pro Phe Phe Arg Ala Asn Ile Arg Lys Tyr Pro 
            340                 345                 350         


Thr Lys Lys Gln Gln Leu His Phe Ile Ser Ser Tyr Leu Pro Ala Phe 
        355                 360                 365             


Gln Asn Asp Phe Glu Asn Leu Ser Thr Glu Glu Lys Ser Ile Ile Lys 
    370                 375                 380                 


Glu Glu Met Leu Leu Glu Val Asn Arg Phe Ala Leu Ala Ser His Phe 
385                 390                 395                 400 


Leu Trp Gly Leu Trp Ser Ile Val Gln Ala Lys Ile Ser Ser Ile Glu 
                405                 410                 415     


Phe Gly Tyr Met Asp Tyr Ala Gln Ala Arg Phe Asp Ala Tyr Phe His 
            420                 425                 430         


Gln Lys Arg Lys Leu Gly Val 
        435                 


<210>  2130
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHKB__Homo_sapiens__NP_005189

<400>  2130

Met Ala Ala Glu Ala Thr Ala Val Ala Gly Ser Gly Ala Val Gly Gly 
1               5                   10                  15      


Cys Leu Ala Lys Asp Gly Leu Gln Gln Ser Lys Cys Pro Asp Thr Thr 
            20                  25                  30          


Pro Lys Arg Arg Arg Ala Ser Ser Leu Ser Arg Asp Ala Glu Arg Arg 
        35                  40                  45              


Ala Tyr Gln Trp Cys Arg Glu Tyr Leu Gly Gly Ala Trp Arg Arg Val 
    50                  55                  60                  


Gln Pro Glu Glu Leu Arg Val Tyr Pro Val Ser Gly Gly Leu Ser Asn 
65                  70                  75                  80  


Leu Leu Phe Arg Cys Ser Leu Pro Asp His Leu Pro Ser Val Gly Glu 
                85                  90                  95      


Glu Pro Arg Glu Val Leu Leu Arg Leu Tyr Gly Ala Ile Leu Gln Gly 
            100                 105                 110         


Val Asp Ser Leu Val Leu Glu Ser Val Met Phe Ala Ile Leu Ala Glu 
        115                 120                 125             


Arg Ser Leu Gly Pro Gln Leu Tyr Gly Val Phe Pro Glu Gly Arg Leu 
    130                 135                 140                 


Glu Gln Tyr Ile Pro Ser Arg Pro Leu Lys Thr Gln Glu Leu Arg Glu 
145                 150                 155                 160 


Pro Val Leu Ser Ala Ala Ile Ala Thr Lys Met Ala Gln Phe His Gly 
                165                 170                 175     


Met Glu Met Pro Phe Thr Lys Glu Pro His Trp Leu Phe Gly Thr Met 
            180                 185                 190         


Glu Arg Tyr Leu Lys Gln Ile Gln Asp Leu Pro Pro Thr Gly Leu Pro 
        195                 200                 205             


Glu Met Asn Leu Leu Glu Met Tyr Ser Leu Lys Asp Glu Met Gly Asn 
    210                 215                 220                 


Leu Arg Lys Leu Leu Glu Ser Thr Pro Ser Pro Val Val Phe Cys His 
225                 230                 235                 240 


Asn Asp Ile Gln Glu Gly Asn Ile Leu Leu Leu Ser Glu Pro Glu Asn 
                245                 250                 255     


Ala Asp Ser Leu Met Leu Val Asp Phe Glu Tyr Ser Ser Tyr Asn Tyr 
            260                 265                 270         


Arg Gly Phe Asp Ile Gly Asn His Phe Cys Glu Trp Val Tyr Asp Tyr 
        275                 280                 285             


Thr His Glu Glu Trp Pro Phe Tyr Lys Ala Arg Pro Thr Asp Tyr Pro 
    290                 295                 300                 


Thr Gln Glu Gln Gln Leu His Phe Ile Arg His Tyr Leu Ala Glu Ala 
305                 310                 315                 320 


Lys Lys Gly Glu Thr Leu Ser Gln Glu Glu Gln Arg Lys Leu Glu Glu 
                325                 330                 335     


Asp Leu Leu Val Glu Val Ser Arg Tyr Ala Leu Ala Ser His Phe Phe 
            340                 345                 350         


Trp Gly Leu Trp Ser Ile Leu Gln Ala Ser Met Ser Thr Ile Glu Phe 
        355                 360                 365             


Gly Tyr Leu Asp Tyr Ala Gln Ser Arg Phe Gln Phe Tyr Phe Gln Gln 
    370                 375                 380                 


Lys Gly Gln Leu Thr Ser Val His Ser Ser Ser 
385                 390                 395 


<210>  2131
<211>  1171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHL1__Homo_sapiens__NP_001240317

<400>  2131

Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe 
1               5                   10                  15      


Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln 
            20                  25                  30          


Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro 
        35                  40                  45              


Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu 
    50                  55                  60                  


Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp 
65                  70                  75                  80  


His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn 
                85                  90                  95      


Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser 
            100                 105                 110         


Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro 
        115                 120                 125             


Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu 
    130                 135                 140                 


Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro 
145                 150                 155                 160 


Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln 
                165                 170                 175     


Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn 
            180                 185                 190         


Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe 
        195                 200                 205             


Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val 
    210                 215                 220                 


Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Thr Glu Ile Gly 
225                 230                 235                 240 


Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro 
                245                 250                 255     


Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu 
            260                 265                 270         


Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val 
        275                 280                 285             


Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Thr Lys 
    290                 295                 300                 


Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp 
305                 310                 315                 320 


Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr 
                325                 330                 335     


His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys 
            340                 345                 350         


Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys 
        355                 360                 365             


Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly 
    370                 375                 380                 


Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg 
385                 390                 395                 400 


Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln 
                405                 410                 415     


Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile 
            420                 425                 430         


Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn 
        435                 440                 445             


Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe 
    450                 455                 460                 


Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys 
465                 470                 475                 480 


Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln 
                485                 490                 495     


Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val 
            500                 505                 510         


Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg 
        515                 520                 525             


Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys 
    530                 535                 540                 


Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu 
545                 550                 555                 560 


Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu 
                565                 570                 575     


Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu 
            580                 585                 590         


Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser 
        595                 600                 605             


Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val 
    610                 615                 620                 


Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln 
625                 630                 635                 640 


Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser 
                645                 650                 655     


Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro 
            660                 665                 670         


Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val 
        675                 680                 685             


Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala 
    690                 695                 700                 


Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His 
705                 710                 715                 720 


Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val 
                725                 730                 735     


Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys 
            740                 745                 750         


Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys 
        755                 760                 765             


Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His 
    770                 775                 780                 


Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys 
785                 790                 795                 800 


Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val 
                805                 810                 815     


Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His 
            820                 825                 830         


Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr 
        835                 840                 845             


Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn 
    850                 855                 860                 


Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu 
865                 870                 875                 880 


Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro 
                885                 890                 895     


Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn 
            900                 905                 910         


Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro 
        915                 920                 925             


Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp 
    930                 935                 940                 


Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly 
945                 950                 955                 960 


Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr 
                965                 970                 975     


Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro 
            980                 985                 990         


Ser Trp His Leu Ser Asn Leu Asn  Ala Thr Thr Lys Tyr  Lys Phe Tyr 
        995                 1000                 1005             


Leu Arg  Ala Cys Thr Ser Gln  Gly Cys Gly Lys Pro  Ile Thr Glu 
    1010                 1015                 1020             


Glu Ser  Ser Thr Leu Gly Glu  Gly Lys Tyr Ala Gly  Leu Tyr Asp 
    1025                 1030                 1035             


Asp Ile  Ser Thr Gln Gly Trp  Phe Ile Gly Leu Met  Cys Ala Ile 
    1040                 1045                 1050             


Ala Leu  Leu Thr Leu Leu Leu  Leu Thr Val Cys Phe  Val Lys Arg 
    1055                 1060                 1065             


Asn Arg  Gly Gly Lys Tyr Ser  Val Lys Glu Lys Glu  Asp Leu His 
    1070                 1075                 1080             


Pro Asp  Pro Glu Ile Gln Ser  Val Lys Asp Glu Thr  Phe Gly Glu 
    1085                 1090                 1095             


Tyr Ser  Asp Ser Asp Glu Lys  Pro Leu Lys Gly Ser  Leu Arg Ser 
    1100                 1105                 1110             


Leu Asn  Arg Asp Met Gln Pro  Thr Glu Ser Ala Asp  Ser Leu Val 
    1115                 1120                 1125             


Glu Tyr  Gly Glu Gly Asp His  Gly Leu Phe Ser Glu  Asp Gly Ser 
    1130                 1135                 1140             


Phe Ile  Gly Ala Tyr Ala Gly  Ser Lys Glu Lys Gly  Ser Val Glu 
    1145                 1150                 1155             


Ser Asn  Gly Ser Ser Thr Ala  Thr Phe Pro Leu Arg  Ala 
    1160                 1165                 1170     


<210>  2132
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHM__Homo_sapiens__NP_000381

<400>  2132

Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala 
        115                 120                 125             


Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr 
                485                 490                 495     


Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser 
            500                 505                 510         


Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys 
625                 630                 635                 640 


Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210>  2133
<211>  656
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHML__Homo_sapiens__NP_001812

<400>  2133

Met Ala Asp Asn Leu Pro Thr Glu Phe Asp Val Val Ile Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln 
            20                  25                  30          


Arg Val Leu His Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln 
    50                  55                  60                  


Asn Asn Asp Ile Gly Glu Glu Ser Thr Val Val Trp Gln Asp Leu Ile 
65                  70                  75                  80  


His Glu Thr Glu Glu Ala Ile Thr Leu Arg Lys Lys Asp Glu Thr Ile 
                85                  90                  95      


Gln His Thr Glu Ala Phe Cys Tyr Ala Ser Gln Asp Met Glu Asp Asn 
            100                 105                 110         


Val Glu Glu Ile Gly Ala Leu Gln Lys Asn Pro Ser Leu Gly Val Ser 
        115                 120                 125             


Asn Thr Phe Thr Glu Val Leu Asp Ser Ala Leu Pro Glu Glu Ser Gln 
    130                 135                 140                 


Leu Ser Tyr Phe Asn Ser Asp Glu Met Pro Ala Lys His Thr Gln Lys 
145                 150                 155                 160 


Ser Asp Thr Glu Ile Ser Leu Glu Val Thr Asp Val Glu Glu Ser Val 
                165                 170                 175     


Glu Lys Glu Lys Tyr Cys Gly Asp Lys Thr Cys Met His Thr Val Ser 
            180                 185                 190         


Asp Lys Asp Gly Asp Lys Asp Glu Ser Lys Ser Thr Val Glu Asp Lys 
        195                 200                 205             


Ala Asp Glu Pro Ile Arg Asn Arg Ile Thr Tyr Ser Gln Ile Val Lys 
    210                 215                 220                 


Glu Gly Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser 
225                 230                 235                 240 


Gln Gly Leu Leu Ile Asp Leu Leu Ile Lys Ser Asp Val Ser Arg Tyr 
                245                 250                 255     


Val Glu Phe Lys Asn Val Thr Arg Ile Leu Ala Phe Arg Glu Gly Lys 
            260                 265                 270         


Val Glu Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Glu 
        275                 280                 285             


Leu Thr Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys 
    290                 295                 300                 


Leu Glu Tyr Glu Gln His Pro Asp Glu Tyr Gln Ala Phe Arg Gln Cys 
305                 310                 315                 320 


Ser Phe Ser Glu Tyr Leu Lys Thr Lys Lys Leu Thr Pro Asn Leu Gln 
                325                 330                 335     


His Phe Val Leu His Ser Ile Ala Met Thr Ser Glu Ser Ser Cys Thr 
            340                 345                 350         


Thr Ile Asp Gly Leu Asn Ala Thr Lys Asn Phe Leu Gln Cys Leu Gly 
        355                 360                 365             


Arg Phe Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu 
    370                 375                 380                 


Ile Pro Gln Gly Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr 
385                 390                 395                 400 


Cys Leu Arg His Lys Val Gln Cys Phe Val Val Asp Lys Glu Ser Gly 
                405                 410                 415     


Arg Cys Lys Ala Ile Ile Asp His Phe Gly Gln Arg Ile Asn Ala Lys 
            420                 425                 430         


Tyr Phe Ile Val Glu Asp Ser Tyr Leu Ser Glu Glu Thr Cys Ser Asn 
        435                 440                 445             


Val Gln Tyr Lys Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Gln Ser 
    450                 455                 460                 


Ile Leu Lys Thr Asp Leu Asp Gln Gln Thr Ser Ile Leu Ile Val Pro 
465                 470                 475                 480 


Pro Ala Glu Pro Gly Ala Cys Ala Val Arg Val Thr Glu Leu Cys Ser 
                485                 490                 495     


Ser Thr Met Thr Cys Met Lys Asp Thr Tyr Leu Val His Leu Thr Cys 
            500                 505                 510         


Ser Ser Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Lys Lys 
        515                 520                 525             


Leu Phe Thr Pro Tyr Thr Glu Thr Glu Ile Asn Glu Glu Glu Leu Thr 
    530                 535                 540                 


Lys Pro Arg Leu Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser 
545                 550                 555                 560 


Gly Ile Ser Arg Ser Ser Tyr Asn Gly Leu Pro Ser Asn Val Tyr Val 
                565                 570                 575     


Cys Ser Gly Pro Asp Cys Gly Leu Gly Asn Glu His Ala Val Lys Gln 
            580                 585                 590         


Ala Glu Thr Leu Phe Gln Glu Ile Phe Pro Thr Glu Glu Phe Cys Pro 
        595                 600                 605             


Pro Pro Pro Asn Pro Glu Asp Ile Ile Phe Asp Gly Asp Asp Lys Gln 
    610                 615                 620                 


Pro Glu Ala Pro Gly Thr Asn Asn Val Val Met Ala Lys Leu Glu Ser 
625                 630                 635                 640 


Ser Glu Glu Ser Lys Asn Leu Glu Ser Pro Glu Lys His Leu Gln Asn 
                645                 650                 655     


<210>  2134
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP1A__Homo_sapiens__NP_001076783

<400>  2134

Met Asp Val His Gly Glu Ala Ala Gly Glu Ala Gly Gln Glu Gly Gly 
1               5                   10                  15      


Glu Gly Leu Gln Gly Gly Ala Gly Gln Ser Glu Glu Gly Pro Ser Ala 
            20                  25                  30          


Glu Lys Cys Arg Val Cys Pro Cys Val Cys Arg Glu Arg His Pro Gln 
        35                  40                  45              


Glu Glu Arg Arg Cys Glu Leu Ala Ser Asp Gly Val Pro Arg Arg Arg 
    50                  55                  60                  


Ser Gly Leu Gln Gly Ala Asp Ser Cys Asp Tyr Glu Gly Gly Asp Gln 
65                  70                  75                  80  


Glu Tyr Gly Pro Gly Asp Gln Ser Pro Gly Gln Gly Pro Glu His His 
                85                  90                  95      


Gly Pro Ala Glu Gly Leu Leu Ser Asp Gly Gln Val Arg Ala Ala Gly 
            100                 105                 110         


Ala Glu Pro Gly Arg Pro Tyr Ile Gly Asp Gly Gly Leu His Glu Leu 
        115                 120                 125             


Gly His His Pro Asp His Ala Ala Gly Ala Gly Gly Gln Pro His His 
    130                 135                 140                 


Ala Asp Arg Arg Gly Glu Trp Pro Gly Gly Ala Gly Pro Ala Gln Pro 
145                 150                 155                 160 


Ala Ala Arg Gly Arg Leu Cys Arg Gly Arg Glu Leu Cys Ala Gln Pro 
                165                 170                 175     


Gly Gly Pro Ala Val Thr Glu Val Gly Arg Leu Glu Glu Leu Ala Val 
            180                 185                 190         


Pro Arg Arg Cys Ala Pro Pro Leu Pro Arg Asp Val Leu Glu Gly Ser 
        195                 200                 205             


Cys Pro Leu Pro Thr Ala Ser Cys Leu Cys Ala Asp Pro Ala Gly Leu 
    210                 215                 220                 


Arg Pro Ala Ala Thr Leu Arg Leu Ser Pro Ala Arg Pro Ala Trp Pro 
225                 230                 235                 240 


<210>  2135
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP1B__Homo_sapiens__NP_065145

<400>  2135

Met Ser Asn Met Glu Lys His Leu Phe Asn Leu Lys Phe Ala Ala Lys 
1               5                   10                  15      


Glu Leu Ser Arg Ser Ala Lys Lys Cys Asp Lys Glu Glu Lys Ala Glu 
            20                  25                  30          


Lys Ala Lys Ile Lys Lys Ala Ile Gln Lys Gly Asn Met Glu Val Ala 
        35                  40                  45              


Arg Ile His Ala Glu Asn Ala Ile Arg Gln Lys Asn Gln Ala Val Asn 
    50                  55                  60                  


Phe Leu Arg Met Ser Ala Arg Val Asp Ala Val Ala Ala Arg Val Gln 
65                  70                  75                  80  


Thr Ala Val Thr Met Gly Lys Val Thr Lys Ser Met Ala Gly Val Val 
                85                  90                  95      


Lys Ser Met Asp Ala Thr Leu Lys Thr Met Asn Leu Glu Lys Ile Ser 
            100                 105                 110         


Ala Leu Met Asp Lys Phe Glu His Gln Phe Glu Thr Leu Asp Val Gln 
        115                 120                 125             


Thr Gln Gln Met Glu Asp Thr Met Ser Ser Thr Thr Thr Leu Thr Thr 
    130                 135                 140                 


Pro Gln Asn Gln Val Asp Met Leu Leu Gln Glu Met Ala Asp Glu Ala 
145                 150                 155                 160 


Gly Leu Asp Leu Asn Met Glu Leu Pro Gln Gly Gln Thr Gly Ser Val 
                165                 170                 175     


Gly Thr Ser Val Ala Ser Ala Glu Gln Asp Glu Leu Ser Gln Arg Leu 
            180                 185                 190         


Ala Arg Leu Arg Asp Gln Val 
        195                 


<210>  2136
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP2B__Homo_sapiens__NP_001231573

<400>  2136

Met Glu Leu Glu Ile Lys Lys Met Ala Lys Ile Gly Asn Lys Glu Ala 
1               5                   10                  15      


Cys Lys Val Leu Ala Lys Gln Leu Val His Leu Arg Lys Gln Lys Thr 
            20                  25                  30          


Arg Thr Phe Ala Val Ser Ser Lys Val Thr Ser Met Ser Thr Gln Thr 
        35                  40                  45              


Lys Val Met Asn Ser Gln Met Lys Met Ala Gly Ala Met Ser Thr Thr 
    50                  55                  60                  


Ala Lys Thr Met Gln Ala Val Asn Lys Lys Met Asp Pro Gln Lys Thr 
65                  70                  75                  80  


Leu Gln Thr Met Gln Asn Phe Gln Lys Glu Asn Met Lys Met Glu Met 
                85                  90                  95      


Thr Glu Glu Met Ile Asn Asp Thr Leu Asp Asp Ile Phe Asp Gly Ser 
            100                 105                 110         


Asp Asp Glu Glu Glu Ser Gln Asp Ile Val Asn Gln Val Leu Asp Glu 
        115                 120                 125             


Ile Gly Ile Glu Ile Ser Gly Lys Met Ala Lys Ala Pro Ser Ala Ala 
    130                 135                 140                 


Arg Ser Leu Pro Ser Ala Ser Thr Ser Lys Ala Thr Ile Ser Asp Glu 
145                 150                 155                 160 


Glu Ile Glu Arg Gln Leu Lys Ala Leu Gly Val Asp 
                165                 170         


<210>  2137
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP3__Homo_sapiens__NP_001005753

<400>  2137

Met Ile Arg Ser Arg Lys Ala Val Ser Lys Leu Tyr Ala Ser Lys Ala 
1               5                   10                  15      


His Met Asn Ser Val Leu Met Gly Met Lys Asn Gln Leu Ala Val Leu 
            20                  25                  30          


Arg Val Ala Gly Ser Leu Gln Lys Ser Thr Glu Val Met Lys Ala Met 
        35                  40                  45              


Gln Ser Leu Val Lys Ile Pro Glu Ile Gln Ala Thr Met Arg Glu Leu 
    50                  55                  60                  


Ser Lys Glu Met Met Lys Ala Gly Ile Ile Glu Glu Met Leu Glu Asp 
65                  70                  75                  80  


Thr Phe Glu Ser Met Asp Asp Gln Glu Glu Met Glu Glu Glu Ala Glu 
                85                  90                  95      


Met Glu Ile Asp Arg Ile Leu Phe Glu Ile Thr Ala Gly Ala Leu Gly 
            100                 105                 110         


Lys Ala Pro Ser Lys Val Thr Asp Ala Leu Pro Glu Pro Glu Pro Pro 
        115                 120                 125             


Gly Ala Met Ala Ala Ser Glu Asp Glu Glu Glu Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ala Met Gln Ser Arg Leu Ala Thr Leu Arg Ser 
145                 150                 155     


<210>  2138
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP4A__Homo_sapiens__NP_054888

<400>  2138

Met Ser Arg Arg Arg Pro Glu Asp Gly Leu Gly Lys Ala Gly Pro Cys 
1               5                   10                  15      


Val Met Arg His His Pro Pro Arg Ser Lys Ala Glu Val Trp Arg Thr 
            20                  25                  30          


Leu Arg Gly Gly Gly Gly Arg Gly Glu Leu Ala Met Ser Gly Leu Gly 
        35                  40                  45              


Arg Leu Phe Gly Lys Gly Lys Lys Glu Lys Gly Pro Thr Pro Glu Glu 
    50                  55                  60                  


Ala Ile Gln Lys Leu Lys Glu Thr Glu Lys Ile Leu Ile Lys Lys Gln 
65                  70                  75                  80  


Glu Phe Leu Glu Gln Lys Ile Gln Gln Glu Leu Gln Thr Ala Lys Lys 
                85                  90                  95      


Tyr Gly Thr Lys Asn Lys Arg Ala Ala Leu Gln Ala Leu Arg Arg Lys 
            100                 105                 110         


Lys Arg Phe Glu Gln Gln Leu Ala Gln Thr Asp Gly Thr Leu Ser Thr 
        115                 120                 125             


Leu Glu Phe Gln Arg Glu Ala Ile Glu Asn Ala Thr Thr Asn Ala Glu 
    130                 135                 140                 


Val Leu Arg Thr Met Glu Leu Ala Ala Gln Ser Met Lys Lys Ala Tyr 
145                 150                 155                 160 


Gln Asp Met Asp Ile Asp Lys Val Asp Glu Leu Met Thr Asp Ile Thr 
                165                 170                 175     


Glu Gln Gln Glu Val Ala Gln Gln Ile Ser Asp Ala Ile Ser Arg Pro 
            180                 185                 190         


Met Gly Phe Gly Asp Asp Val Asp Glu Asp Glu Leu Leu Glu Glu Leu 
        195                 200                 205             


Glu Glu Leu Glu Gln Glu Glu Leu Ala Gln Glu Leu Leu Asn Val Gly 
    210                 215                 220                 


Asp Lys Glu Glu Glu Pro Ser Val Lys Leu Pro Ser Val Pro Ser Thr 
225                 230                 235                 240 


His Leu Pro Ala Gly Pro Ala Pro Lys Val Asp Glu Asp Glu Glu Ala 
                245                 250                 255     


Leu Lys Gln Leu Ala Glu Trp Val Ser 
            260                 265 


<210>  2139
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP4B__Homo_sapiens__NP_789782

<400>  2139

Met Ser Val Phe Gly Lys Leu Phe Gly Ala Gly Gly Gly Lys Ala Gly 
1               5                   10                  15      


Lys Gly Gly Pro Thr Pro Gln Glu Ala Ile Gln Arg Leu Arg Asp Thr 
            20                  25                  30          


Glu Glu Met Leu Ser Lys Lys Gln Glu Phe Leu Glu Lys Lys Ile Glu 
        35                  40                  45              


Gln Glu Leu Thr Ala Ala Lys Lys His Gly Thr Lys Asn Lys Arg Ala 
    50                  55                  60                  


Ala Leu Gln Ala Leu Lys Arg Lys Lys Arg Tyr Glu Lys Gln Leu Ala 
65                  70                  75                  80  


Gln Ile Asp Gly Thr Leu Ser Thr Ile Glu Phe Gln Arg Glu Ala Leu 
                85                  90                  95      


Glu Asn Ala Asn Thr Asn Thr Glu Val Leu Lys Asn Met Gly Tyr Ala 
            100                 105                 110         


Ala Lys Ala Met Lys Ala Ala His Asp Asn Met Asp Ile Asp Lys Val 
        115                 120                 125             


Asp Glu Leu Met Gln Asp Ile Ala Asp Gln Gln Glu Leu Ala Glu Glu 
    130                 135                 140                 


Ile Ser Thr Ala Ile Ser Lys Pro Val Gly Phe Gly Glu Glu Phe Asp 
145                 150                 155                 160 


Glu Asp Glu Leu Met Ala Glu Leu Glu Glu Leu Glu Gln Glu Glu Leu 
                165                 170                 175     


Asp Lys Asn Leu Leu Glu Ile Ser Gly Pro Glu Thr Val Pro Leu Pro 
            180                 185                 190         


Asn Val Pro Ser Ile Ala Leu Pro Ser Lys Pro Ala Lys Lys Lys Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Met Lys Glu Leu Glu Asn Trp Ala Gly Ser Met 
    210                 215                 220                 


<210>  2140
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP4C__Homo_sapiens__NP_689497

<400>  2140

Met Ser Lys Leu Gly Lys Phe Phe Lys Gly Gly Gly Ser Ser Lys Ser 
1               5                   10                  15      


Arg Ala Ala Pro Ser Pro Gln Glu Ala Leu Val Arg Leu Arg Glu Thr 
            20                  25                  30          


Glu Glu Met Leu Gly Lys Lys Gln Glu Tyr Leu Glu Asn Arg Ile Gln 
        35                  40                  45              


Arg Glu Ile Ala Leu Ala Lys Lys His Gly Thr Gln Asn Lys Arg Ala 
    50                  55                  60                  


Ala Leu Gln Ala Leu Lys Arg Lys Lys Arg Phe Glu Lys Gln Leu Thr 
65                  70                  75                  80  


Gln Ile Asp Gly Thr Leu Ser Thr Ile Glu Phe Gln Arg Glu Ala Leu 
                85                  90                  95      


Glu Asn Ser His Thr Asn Thr Glu Val Leu Arg Asn Met Gly Phe Ala 
            100                 105                 110         


Ala Lys Ala Met Lys Ser Val His Glu Asn Met Asp Leu Asn Lys Ile 
        115                 120                 125             


Asp Asp Leu Met Gln Glu Ile Thr Glu Gln Gln Asp Ile Ala Gln Glu 
    130                 135                 140                 


Ile Ser Glu Ala Phe Ser Gln Arg Val Gly Phe Gly Asp Asp Phe Asp 
145                 150                 155                 160 


Glu Asp Glu Leu Met Ala Glu Leu Glu Glu Leu Glu Gln Glu Glu Leu 
                165                 170                 175     


Asn Lys Lys Met Thr Asn Ile Arg Leu Pro Asn Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Pro Ala Gln Pro Asn Arg Lys Pro Gly Met Ser Ser Thr Ala Arg 
        195                 200                 205             


Arg Ser Arg Ala Ala Ser Ser Gln Arg Ala Glu Glu Glu Asp Asp Asp 
    210                 215                 220                 


Ile Lys Gln Leu Ala Ala Trp Ala Thr 
225                 230             


<210>  2141
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHMP5__Homo_sapiens__NP_001182465

<400>  2141

Met Asn Arg Leu Phe Gly Lys Ala Lys Pro Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Thr Asp Cys Ile Gly Thr Val Asp Ser Arg Ala Glu Ser Ile Asp 
            20                  25                  30          


Lys Lys Ile Ser Arg Leu Asp Ala Glu Leu Val Lys Tyr Lys Asp Gln 
        35                  40                  45              


Ile Lys Lys Met Arg Glu Gly Pro Ala Lys Asn Met Val Lys Gln Lys 
    50                  55                  60                  


Ala Leu Arg Val Leu Lys Gln Lys Arg Met Tyr Glu Gln Gln Arg Asp 
65                  70                  75                  80  


Asn Leu Ala Gln Gln Ser Phe Asn Met Glu Gln Ala Asn Tyr Thr Ile 
                85                  90                  95      


Gln Ser Leu Lys Asp Thr Lys Thr Thr Val Asp Ala Met Lys Leu Gly 
            100                 105                 110         


Val Lys Glu Met Lys Lys Ala Tyr Lys Gln Val Lys Ile Asp Gln Ile 
        115                 120                 125             


Glu Asp Leu Gln Asp Gln Leu Glu Asp Met Met Glu Asp Ala Asn Glu 
    130                 135                 140                 


Ile Gln Glu Ala Leu Ser Arg Ser Tyr Gly Thr Pro Glu Leu Asp Glu 
145                 150                 155                 160 


Asp Asp Leu Glu Ala Gly Trp Ser Ser Gly Gly 
                165                 170     


<210>  2142
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHN1__Homo_sapiens__NP_001020372

<400>  2142

Met Ala Leu Thr Leu Phe Asp Thr Asp Glu Tyr Arg Pro Pro Val Trp 
1               5                   10                  15      


Lys Ser Tyr Leu Tyr Gln Leu Gln Gln Glu Ala Pro His Pro Arg Arg 
            20                  25                  30          


Ile Thr Cys Thr Cys Glu Val Glu Asn Arg Pro Lys Tyr Tyr Gly Arg 
        35                  40                  45              


Glu Phe His Gly Met Ile Ser Arg Glu Ala Ala Asp Gln Leu Leu Ile 
    50                  55                  60                  


Val Ala Glu Gly Ser Tyr Leu Ile Arg Glu Ser Gln Arg Gln Pro Gly 
65                  70                  75                  80  


Thr Tyr Thr Leu Ala Leu Arg Phe Gly Ser Gln Thr Arg Asn Phe Arg 
                85                  90                  95      


Leu Tyr Tyr Asp Gly Lys His Phe Val Gly Glu Lys Arg Phe Glu Ser 
            100                 105                 110         


Ile His Asp Leu Val Thr Asp Gly Leu Ile Thr Leu Tyr Ile Glu Thr 
        115                 120                 125             


Lys Ala Ala Glu Tyr Ile Ala Lys Met Thr Ile Asn Pro Ile Tyr Glu 
    130                 135                 140                 


His Val Gly Tyr Thr Thr Leu Asn Arg Glu Pro Ala Tyr Lys Lys His 
145                 150                 155                 160 


Met Pro Val Leu Lys Glu Thr His Asp Glu Arg Asp Ser Thr Gly Gln 
                165                 170                 175     


Asp Gly Val Ser Glu Lys Arg Val His Thr Phe Arg Gly Pro His Trp 
            180                 185                 190         


Cys Glu Tyr Cys Ala Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val 
        195                 200                 205             


Lys Cys Ala Asp Cys Gly Leu Asn Val His Lys Gln Cys Ser Lys Met 
    210                 215                 220                 


Val Pro Asn Asp Cys Lys Pro Asp Leu Lys His Val Lys Lys Val Tyr 
225                 230                 235                 240 


Ser Cys Asp Leu Thr Thr Leu Val Lys Ala His Thr Thr Lys Arg Pro 
                245                 250                 255     


Met Val Val Asp Met Cys Ile Arg Glu Ile Glu Ser Arg Gly Leu Asn 
            260                 265                 270         


Ser Glu Gly Leu Tyr Arg Val Ser Gly Phe Ser Asp Leu Ile Glu Asp 
        275                 280                 285             


Val Lys Met Ala Phe Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Val 
    290                 295                 300                 


Asn Met Tyr Glu Asp Ile Asn Ile Ile Thr Gly Ala Leu Lys Leu Tyr 
305                 310                 315                 320 


Phe Arg Asp Leu Pro Ile Pro Leu Ile Thr Tyr Asp Ala Tyr Pro Lys 
                325                 330                 335     


Phe Ile Glu Ser Ala Lys Ile Met Asp Pro Asp Glu Gln Leu Glu Thr 
            340                 345                 350         


Leu His Glu Ala Leu Lys Leu Leu Pro Pro Ala His Cys Glu Thr Leu 
        355                 360                 365             


Arg Tyr Leu Met Ala His Leu Lys Arg Val Thr Leu His Glu Lys Glu 
    370                 375                 380                 


Asn Leu Met Asn Ala Glu Asn Leu Gly Ile Val Phe Gly Pro Thr Leu 
385                 390                 395                 400 


Met Arg Ser Pro Glu Leu Asp Ala Met Ala Ala Leu Asn Asp Ile Arg 
                405                 410                 415     


Tyr Gln Arg Leu Val Val Glu Leu Leu Ile Lys Asn Glu Asp Ile Leu 
            420                 425                 430         


Phe 
    


<210>  2143
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHN2__Homo_sapiens__NP_001035025

<400>  2143

Met Phe Ser Glu Glu Leu Trp Leu Glu Asn Glu Lys Lys Cys Ala Val 
1               5                   10                  15      


Val Arg Lys Ser Lys Gln Gly Arg Lys Arg Gln Glu Leu Leu Ala Val 
            20                  25                  30          


Ala Phe Gly Val Lys Val Gly Val Lys Gly Gly Phe Leu Trp Pro Pro 
        35                  40                  45              


Leu Lys Leu Phe Ala Cys Ser Gln Ile Ser Ser Leu Val Arg Arg Ala 
    50                  55                  60                  


Ala Leu Thr His Asn Asp Asn His Phe Asn Tyr Glu Lys Thr His Asn 
65                  70                  75                  80  


Phe Lys Val His Thr Phe Arg Gly Pro His Trp Cys Glu Tyr Cys Ala 
                85                  90                  95      


Asn Phe Met Trp Gly Leu Ile Ala Gln Gly Val Arg Cys Ser Asp Cys 
            100                 105                 110         


Gly Leu Asn Val His Lys Gln Cys Ser Lys His Val Pro Asn Asp Cys 
        115                 120                 125             


Gln Pro Asp Leu Lys Arg Ile Lys Lys Val Tyr Cys Cys Asp Leu Thr 
    130                 135                 140                 


Thr Leu Val Lys Ala His Asn Thr Gln Arg Pro Met Val Val Asp Ile 
145                 150                 155                 160 


Cys Ile Arg Glu Ile Glu Ala Arg Gly Leu Lys Ser Glu Gly Leu Tyr 
                165                 170                 175     


Arg Val Ser Gly Phe Thr Glu His Ile Glu Asp Val Lys Met Ala Phe 
            180                 185                 190         


Asp Arg Asp Gly Glu Lys Ala Asp Ile Ser Ala Asn Val Tyr Pro Asp 
        195                 200                 205             


Ile Asn Ile Ile Thr Gly Ala Leu Lys Leu Tyr Phe Arg Asp Leu Pro 
    210                 215                 220                 


Ile Pro Val Ile Thr Tyr Asp Thr Tyr Ser Lys Phe Ile Asp Ala Ala 
225                 230                 235                 240 


Lys Ile Ser Asn Ala Asp Glu Arg Leu Glu Ala Val His Glu Val Leu 
                245                 250                 255     


Met Leu Leu Pro Pro Ala His Tyr Glu Thr Leu Arg Tyr Leu Met Ile 
            260                 265                 270         


His Leu Lys Lys Val Thr Met Asn Glu Lys Asp Asn Phe Met Asn Ala 
        275                 280                 285             


Glu Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Met Arg Pro Pro Glu 
    290                 295                 300                 


Asp Ser Thr Leu Thr Thr Leu His Asp Met Arg Tyr Gln Lys Leu Ile 
305                 310                 315                 320 


Val Gln Ile Leu Ile Glu Asn Glu Asp Val Leu Phe 
                325                 330         


<210>  2144
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHODL__Homo_sapiens__NP_001191103

<400>  2144

Met Thr Ala Gly Ser Ala His Ser Gln Lys Val Cys Phe Ala Asp Phe 
1               5                   10                  15      


Lys His Pro Cys Tyr Lys Met Ala Tyr Phe His Glu Leu Ser Ser Arg 
            20                  25                  30          


Val Ser Phe Gln Glu Ala Arg Leu Ala Cys Glu Ser Glu Gly Gly Val 
        35                  40                  45              


Leu Leu Ser Leu Glu Asn Glu Ala Glu Gln Lys Leu Ile Glu Ser Met 
    50                  55                  60                  


Leu Gln Asn Leu Thr Lys Pro Gly Thr Gly Ile Ser Asp Gly Asp Phe 
65                  70                  75                  80  


Trp Ile Gly Leu Trp Arg Asn Gly Asp Gly Gln Thr Ser Gly Ala Cys 
                85                  90                  95      


Pro Asp Leu Tyr Gln Trp Ser Asp Gly Ser Asn Ser Gln Tyr Arg Asn 
            100                 105                 110         


Trp Tyr Thr Asp Glu Pro Ser Cys Gly Ser Glu Lys Cys Val Val Met 
        115                 120                 125             


Tyr His Gln Pro Thr Ala Asn Pro Gly Leu Gly Gly Pro Tyr Leu Tyr 
    130                 135                 140                 


Gln Trp Asn Asp Asp Arg Cys Asn Met Lys His Asn Tyr Ile Cys Lys 
145                 150                 155                 160 


Tyr Glu Pro Glu Ile Asn Pro Thr Ala Pro Val Glu Lys Pro Tyr Leu 
                165                 170                 175     


Thr Asn Gln Pro Gly Asp Thr His Gln Asn Val Val Val Thr Glu Ala 
            180                 185                 190         


Gly Ile Ile Pro Asn Leu Ile Tyr Val Val Ile Pro Thr Ile Pro Leu 
        195                 200                 205             


Leu Leu Leu Ile Leu Val Ala Phe Gly Thr Cys Cys Phe Gln Met Leu 
    210                 215                 220                 


His Lys Ser Lys Gly Arg Thr Lys Thr Ser Pro Asn Gln Ser Thr Leu 
225                 230                 235                 240 


Trp Ile Ser Lys Ser Thr Arg Lys Glu Ser Gly Met Glu Val 
                245                 250                 


<210>  2145
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHORDC1__Homo_sapiens__NP_001137545

<400>  2145

Met Ala Leu Leu Cys Tyr Asn Arg Gly Cys Gly Gln Arg Phe Asp Pro 
1               5                   10                  15      


Glu Thr Asn Ser Asp Asp Ala Cys Thr Tyr His Pro Gly Val Pro Val 
            20                  25                  30          


Phe His Asp Ala Leu Lys Gly Cys Thr Lys Gly Arg His Asn Ser Glu 
        35                  40                  45              


Lys Pro Pro Glu Pro Val Lys Pro Glu Val Lys Thr Thr Glu Lys Lys 
    50                  55                  60                  


Glu Leu Cys Glu Leu Lys Pro Lys Phe Gln Glu His Ile Ile Gln Ala 
65                  70                  75                  80  


Pro Lys Pro Val Glu Ala Ile Lys Arg Pro Ser Pro Asp Glu Pro Met 
                85                  90                  95      


Thr Asn Leu Glu Leu Lys Ile Ser Ala Ser Leu Lys Gln Ala Leu Asp 
            100                 105                 110         


Lys Leu Lys Leu Ser Ser Gly Asn Glu Glu Asn Lys Lys Glu Glu Asp 
        115                 120                 125             


Asn Asp Glu Ile Lys Ile Gly Thr Ser Cys Lys Asn Gly Gly Cys Ser 
    130                 135                 140                 


Lys Thr Tyr Gln Gly Leu Glu Ser Leu Glu Glu Val Cys Val Tyr His 
145                 150                 155                 160 


Ser Gly Val Pro Ile Phe His Glu Gly Met Lys Tyr Trp Ser Cys Cys 
                165                 170                 175     


Arg Arg Lys Thr Ser Asp Phe Asn Thr Phe Leu Ala Gln Glu Gly Cys 
            180                 185                 190         


Thr Lys Gly Lys His Met Trp Thr Lys Lys Asp Ala Gly Lys Lys Val 
        195                 200                 205             


Val Pro Cys Arg His Asp Trp His Gln Thr Gly Gly Glu Val Thr Ile 
    210                 215                 220                 


Ser Val Tyr Ala Lys Asn Ser Leu Pro Glu Leu Ser Arg Val Glu Ala 
225                 230                 235                 240 


Asn Ser Thr Leu Leu Asn Val His Ile Val Phe Glu Gly Glu Lys Glu 
                245                 250                 255     


Phe Asp Gln Asn Val Lys Leu Trp Gly Val Ile Asp Val Lys Arg Ser 
            260                 265                 270         


Tyr Val Thr Met Thr Ala Thr Lys Ile Glu Ile Thr Met Arg Lys Ala 
        275                 280                 285             


Glu Pro Met Gln Trp Ala Ser Leu Glu Leu Pro Ala Ala Lys Lys Gln 
    290                 295                 300                 


Glu Lys Gln Lys Asp Ala Thr Thr Asp 
305                 310             


<210>  2146
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHP1__Homo_sapiens__NP_009167

<400>  2146

Met Gly Ser Arg Ala Ser Thr Leu Leu Arg Asp Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Lys Lys Glu Thr Gly Phe Ser His Ser Gln Ile Thr Arg Leu Tyr 
            20                  25                  30          


Ser Arg Phe Thr Ser Leu Asp Lys Gly Glu Asn Gly Thr Leu Ser Arg 
        35                  40                  45              


Glu Asp Phe Gln Arg Ile Pro Glu Leu Ala Ile Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Asn Ala Phe Phe Pro Glu Gly Glu Asp Gln Val Asn Phe 
65                  70                  75                  80  


Arg Gly Phe Met Arg Thr Leu Ala His Phe Arg Pro Ile Glu Asp Asn 
                85                  90                  95      


Glu Lys Ser Lys Asp Val Asn Gly Pro Glu Pro Leu Asn Ser Arg Ser 
            100                 105                 110         


Asn Lys Leu His Phe Ala Phe Arg Leu Tyr Asp Leu Asp Lys Asp Glu 
        115                 120                 125             


Lys Ile Ser Arg Asp Glu Leu Leu Gln Val Leu Arg Met Met Val Gly 
    130                 135                 140                 


Val Asn Ile Ser Asp Glu Gln Leu Gly Ser Ile Ala Asp Arg Thr Ile 
145                 150                 155                 160 


Gln Glu Ala Asp Gln Asp Gly Asp Ser Ala Ile Ser Phe Thr Glu Phe 
                165                 170                 175     


Val Lys Val Leu Glu Lys Val Asp Val Glu Gln Lys Met Ser Ile Arg 
            180                 185                 190         


Phe Leu His 
        195 


<210>  2147
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHP2__Homo_sapiens__NP_071380

<400>  2147

Met Gly Ser Arg Ser Ser His Ala Ala Val Ile Pro Asp Gly Asp Ser 
1               5                   10                  15      


Ile Arg Arg Glu Thr Gly Phe Ser Gln Ala Ser Leu Leu Arg Leu His 
            20                  25                  30          


His Arg Phe Arg Ala Leu Asp Arg Asn Lys Lys Gly Tyr Leu Ser Arg 
        35                  40                  45              


Met Asp Leu Gln Gln Ile Gly Ala Leu Ala Val Asn Pro Leu Gly Asp 
    50                  55                  60                  


Arg Ile Ile Glu Ser Phe Phe Pro Asp Gly Ser Gln Arg Val Asp Phe 
65                  70                  75                  80  


Pro Gly Phe Val Arg Val Leu Ala His Phe Arg Pro Val Glu Asp Glu 
                85                  90                  95      


Asp Thr Glu Thr Gln Asp Pro Lys Lys Pro Glu Pro Leu Asn Ser Arg 
            100                 105                 110         


Arg Asn Lys Leu His Tyr Ala Phe Gln Leu Tyr Asp Leu Asp Arg Asp 
        115                 120                 125             


Gly Lys Ile Ser Arg His Glu Met Leu Gln Val Leu Arg Leu Met Val 
    130                 135                 140                 


Gly Val Gln Val Thr Glu Glu Gln Leu Glu Asn Ile Ala Asp Arg Thr 
145                 150                 155                 160 


Val Gln Glu Ala Asp Glu Asp Gly Asp Gly Ala Val Ser Phe Val Glu 
                165                 170                 175     


Phe Thr Lys Ser Leu Glu Lys Met Asp Val Glu Gln Lys Met Ser Ile 
            180                 185                 190         


Arg Ile Leu Lys 
        195     


<210>  2148
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHPF__Homo_sapiens__NP_078812

<400>  2148

Met Arg Ala Ser Leu Leu Leu Ser Val Leu Arg Pro Ala Gly Pro Val 
1               5                   10                  15      


Ala Val Gly Ile Ser Leu Gly Phe Thr Leu Ser Leu Leu Ser Val Thr 
            20                  25                  30          


Trp Val Glu Glu Pro Cys Gly Pro Gly Pro Pro Gln Pro Gly Asp Ser 
        35                  40                  45              


Glu Leu Pro Pro Arg Gly Asn Thr Asn Ala Ala Arg Arg Pro Asn Ser 
    50                  55                  60                  


Val Gln Pro Gly Ala Glu Arg Glu Lys Pro Gly Ala Gly Glu Gly Ala 
65                  70                  75                  80  


Gly Glu Asn Trp Glu Pro Arg Val Leu Pro Tyr His Pro Ala Gln Pro 
                85                  90                  95      


Gly Gln Ala Ala Lys Lys Ala Val Arg Thr Arg Tyr Ile Ser Thr Glu 
            100                 105                 110         


Leu Gly Ile Arg Gln Arg Leu Leu Val Ala Val Leu Thr Ser Gln Thr 
        115                 120                 125             


Thr Leu Pro Thr Leu Gly Val Ala Val Asn Arg Thr Leu Gly His Arg 
    130                 135                 140                 


Leu Glu Arg Val Val Phe Leu Thr Gly Ala Arg Gly Arg Arg Ala Pro 
145                 150                 155                 160 


Pro Gly Met Ala Val Val Thr Leu Gly Glu Glu Arg Pro Ile Gly His 
                165                 170                 175     


Leu His Leu Ala Leu Arg His Leu Leu Glu Gln His Gly Asp Asp Phe 
            180                 185                 190         


Asp Trp Phe Phe Leu Val Pro Asp Thr Thr Tyr Thr Glu Ala His Gly 
        195                 200                 205             


Leu Ala Arg Leu Thr Gly His Leu Ser Leu Ala Ser Ala Ala His Leu 
    210                 215                 220                 


Tyr Leu Gly Arg Pro Gln Asp Phe Ile Gly Gly Glu Pro Thr Pro Gly 
225                 230                 235                 240 


Arg Tyr Cys His Gly Gly Phe Gly Val Leu Leu Ser Arg Met Leu Leu 
                245                 250                 255     


Gln Gln Leu Arg Pro His Leu Glu Gly Cys Arg Asn Asp Ile Val Ser 
            260                 265                 270         


Ala Arg Pro Asp Glu Trp Leu Gly Arg Cys Ile Leu Asp Ala Thr Gly 
        275                 280                 285             


Val Gly Cys Thr Gly Asp His Glu Gly Val His Tyr Ser His Leu Glu 
    290                 295                 300                 


Leu Ser Pro Gly Glu Pro Val Gln Glu Gly Asp Pro His Phe Arg Ser 
305                 310                 315                 320 


Ala Leu Thr Ala His Pro Val Arg Asp Pro Val His Met Tyr Gln Leu 
                325                 330                 335     


His Lys Ala Phe Ala Arg Ala Glu Leu Glu Arg Thr Tyr Gln Glu Ile 
            340                 345                 350         


Gln Glu Leu Gln Trp Glu Ile Gln Asn Thr Ser His Leu Ala Val Asp 
        355                 360                 365             


Gly Asp Arg Ala Ala Ala Trp Pro Val Gly Ile Pro Ala Pro Ser Arg 
    370                 375                 380                 


Pro Ala Ser Arg Phe Glu Val Leu Arg Trp Asp Tyr Phe Thr Glu Gln 
385                 390                 395                 400 


His Ala Phe Ser Cys Ala Asp Gly Ser Pro Arg Cys Pro Leu Arg Gly 
                405                 410                 415     


Ala Asp Arg Ala Asp Val Ala Asp Val Leu Gly Thr Ala Leu Glu Glu 
            420                 425                 430         


Leu Asn Arg Arg Tyr His Pro Ala Leu Arg Leu Gln Lys Gln Gln Leu 
        435                 440                 445             


Val Asn Gly Tyr Arg Arg Phe Asp Pro Ala Arg Gly Met Glu Tyr Thr 
    450                 455                 460                 


Leu Asp Leu Gln Leu Glu Ala Leu Thr Pro Gln Gly Gly Arg Arg Pro 
465                 470                 475                 480 


Leu Thr Arg Arg Val Gln Leu Leu Arg Pro Leu Ser Arg Val Glu Ile 
                485                 490                 495     


Leu Pro Val Pro Tyr Val Thr Glu Ala Ser Arg Leu Thr Val Leu Leu 
            500                 505                 510         


Pro Leu Ala Ala Ala Glu Arg Asp Leu Ala Pro Gly Phe Leu Glu Ala 
        515                 520                 525             


Phe Ala Thr Ala Ala Leu Glu Pro Gly Asp Ala Ala Ala Ala Leu Thr 
    530                 535                 540                 


Leu Leu Leu Leu Tyr Glu Pro Arg Gln Ala Gln Arg Val Ala His Ala 
545                 550                 555                 560 


Asp Val Phe Ala Pro Val Lys Ala His Val Ala Glu Leu Glu Arg Arg 
                565                 570                 575     


Phe Pro Gly Ala Arg Val Pro Trp Leu Ser Val Gln Thr Ala Ala Pro 
            580                 585                 590         


Ser Pro Leu Arg Leu Met Asp Leu Leu Ser Lys Lys His Pro Leu Asp 
        595                 600                 605             


Thr Leu Phe Leu Leu Ala Gly Pro Asp Thr Val Leu Thr Pro Asp Phe 
    610                 615                 620                 


Leu Asn Arg Cys Arg Met His Ala Ile Ser Gly Trp Gln Ala Phe Phe 
625                 630                 635                 640 


Pro Met His Phe Gln Ala Phe His Pro Ala Val Ala Pro Pro Gln Gly 
                645                 650                 655     


Pro Gly Pro Pro Glu Leu Gly Arg Asp Thr Gly Arg Phe Asp Arg Gln 
            660                 665                 670         


Ala Ala Ser Glu Ala Cys Phe Tyr Asn Ser Asp Tyr Val Ala Ala Arg 
        675                 680                 685             


Gly Arg Leu Ala Ala Ala Ser Glu Gln Glu Glu Glu Leu Leu Glu Ser 
    690                 695                 700                 


Leu Asp Val Tyr Glu Leu Phe Leu His Phe Ser Ser Leu His Val Leu 
705                 710                 715                 720 


Arg Ala Val Glu Pro Ala Leu Leu Gln Arg Tyr Arg Ala Gln Thr Cys 
                725                 730                 735     


Ser Ala Arg Leu Ser Glu Asp Leu Tyr His Arg Cys Leu Gln Ser Val 
            740                 745                 750         


Leu Glu Gly Leu Gly Ser Arg Thr Gln Leu Ala Met Leu Leu Phe Glu 
        755                 760                 765             


Gln Glu Gln Gly Asn Ser Thr 
    770                 775 


<210>  2149
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHPT1__Homo_sapiens__NP_064629

<400>  2149

Met Ala Ala Gly Ala Gly Ala Gly Ser Ala Pro Arg Trp Leu Arg Ala 
1               5                   10                  15      


Leu Ser Glu Pro Leu Ser Ala Ala Gln Leu Arg Arg Leu Glu Glu His 
            20                  25                  30          


Arg Tyr Ser Ala Ala Gly Val Ser Leu Leu Glu Pro Pro Leu Gln Leu 
        35                  40                  45              


Tyr Trp Thr Trp Leu Leu Gln Trp Ile Pro Leu Trp Met Ala Pro Asn 
    50                  55                  60                  


Ser Ile Thr Leu Leu Gly Leu Ala Val Asn Val Val Thr Thr Leu Val 
65                  70                  75                  80  


Leu Ile Ser Tyr Cys Pro Thr Ala Thr Glu Glu Ala Pro Tyr Trp Thr 
                85                  90                  95      


Tyr Leu Leu Cys Ala Leu Gly Leu Phe Ile Tyr Gln Ser Leu Asp Ala 
            100                 105                 110         


Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn Ser Cys Ser Pro Leu Gly 
        115                 120                 125             


Glu Leu Phe Asp His Gly Cys Asp Ser Leu Ser Thr Val Phe Met Ala 
    130                 135                 140                 


Val Gly Ala Ser Ile Ala Ala Arg Leu Gly Thr Tyr Pro Asp Trp Phe 
145                 150                 155                 160 


Phe Phe Cys Ser Phe Ile Gly Met Phe Val Phe Tyr Cys Ala His Trp 
                165                 170                 175     


Gln Thr Tyr Val Ser Gly Met Leu Arg Phe Gly Lys Val Asp Val Thr 
            180                 185                 190         


Glu Ile Gln Ile Ala Leu Val Ile Val Phe Val Leu Ser Ala Phe Gly 
        195                 200                 205             


Gly Ala Thr Met Trp Asp Tyr Thr Ile Pro Ile Leu Glu Ile Lys Leu 
    210                 215                 220                 


Lys Ile Leu Pro Val Leu Gly Phe Leu Gly Gly Val Ile Phe Ser Cys 
225                 230                 235                 240 


Ser Asn Tyr Phe His Val Ile Leu His Gly Gly Val Gly Lys Asn Gly 
                245                 250                 255     


Ser Thr Ile Ala Gly Thr Ser Val Leu Ser Pro Gly Leu His Ile Gly 
            260                 265                 270         


Leu Ile Ile Ile Leu Ala Ile Met Ile Tyr Lys Lys Ser Ala Thr Asp 
        275                 280                 285             


Val Phe Glu Lys His Pro Cys Leu Tyr Ile Leu Met Phe Gly Cys Val 
    290                 295                 300                 


Phe Ala Lys Val Ser Gln Lys Leu Val Val Ala His Met Thr Lys Ser 
305                 310                 315                 320 


Glu Leu Tyr Leu Gln Asp Thr Val Phe Leu Gly Pro Gly Leu Leu Phe 
                325                 330                 335     


Leu Asp Gln Tyr Phe Asn Asn Phe Ile Asp Glu Tyr Val Val Leu Trp 
            340                 345                 350         


Met Ala Met Val Ile Ser Ser Phe Asp Met Val Ile Tyr Phe Ser Ala 
        355                 360                 365             


Leu Cys Leu Gln Ile Ser Arg His Leu His Leu Asn Ile Phe Lys Thr 
    370                 375                 380                 


Ala Cys His Gln Ala Pro Glu Gln Val Gln Val Leu Ser Ser Lys Ser 
385                 390                 395                 400 


His Gln Asn Asn Met Asp 
                405     


<210>  2150
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRAC1__Homo_sapiens__NP_059140

<400>  2150

Met Ala Asp Val Val Val Gly Lys Asp Lys Gly Gly Glu Gln Arg Leu 
1               5                   10                  15      


Ile Ser Leu Pro Leu Ser Arg Ile Arg Val Ile Met Lys Ser Ser Pro 
            20                  25                  30          


Glu Val Ser Ser Ile Asn Gln Glu Ala Leu Val Leu Thr Ala Lys Ala 
        35                  40                  45              


Thr Glu Leu Phe Val Gln Cys Leu Ala Thr Tyr Ser Tyr Arg His Gly 
    50                  55                  60                  


Ser Gly Lys Glu Lys Lys Val Leu Thr Tyr Ser Asp Leu Ala Asn Thr 
65                  70                  75                  80  


Ala Gln Gln Ser Glu Thr Phe Gln Phe Leu Ala Asp Ile Leu Pro Lys 
                85                  90                  95      


Lys Ile Leu Ala Ser Lys Tyr Leu Lys Met Leu Lys Glu Glu Lys Arg 
            100                 105                 110         


Glu Glu Asp Glu Glu Asn Asp Asn Asp Asn Glu Ser Asp His Asp Glu 
        115                 120                 125             


Ala Asp Ser 
    130     


<210>  2151
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRD__Homo_sapiens__NP_001291401

<400>  2151

Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 
            20                  25                  30          


Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 
        35                  40                  45              


Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 
    50                  55                  60                  


His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 
65                  70                  75                  80  


Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Thr Arg Gly Pro Gly Arg 
                85                  90                  95      


Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Thr Pro Ala Cys Gly 
            100                 105                 110         


Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Thr Cys Pro Gln Glu 
        115                 120                 125             


Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 
    130                 135                 140                 


Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 
145                 150                 155                 160 


Glu Glu Arg Ala Arg Gly Asp Gly His Thr Asp Phe Val Ala Leu Leu 
                165                 170                 175     


Thr Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 
            180                 185                 190         


Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 
        195                 200                 205             


Thr Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 
    210                 215                 220                 


Pro Ala Ala Pro Thr Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 
225                 230                 235                 240 


Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 
                245                 250                 255     


Ala Leu Val Thr Leu Thr His Pro Ser Gly Glu Val Trp Gly Pro Leu 
            260                 265                 270         


Ile Arg His Arg Ala Leu Ala Ala Glu Thr Phe Ser Ala Ile Leu Thr 
        275                 280                 285             


Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Thr Leu Leu Thr 
    290                 295                 300                 


Leu Ser Asp Thr Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 
305                 310                 315                 320 


Leu Leu Glu Pro Arg Ser Gly Gly Leu Thr Gln Val Pro Leu Arg Leu 
                325                 330                 335     


Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 
            340                 345                 350         


Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Thr Val 
        355                 360                 365             


Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 
    370                 375                 380                 


Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 
385                 390                 395                 400 


Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 
                405                 410                 415     


Ile Pro Val Gln Thr Gly Ala Ala Gly Ser Ala Ser Leu Thr Leu Leu 
            420                 425                 430         


Gly Asn Gly Ser Leu Ile Tyr Gln Val Gln Val Val Gly Thr Ser Ser 
        435                 440                 445             


Glu Val Val Ala Met Thr Leu Glu Thr Lys Pro Gln Arg Arg Asp Gln 
    450                 455                 460                 


Arg Thr Val Leu Cys His Met Ala Gly Leu Gln Pro Gly Gly His Thr 
465                 470                 475                 480 


Ala Val Gly Ile Cys Pro Gly Leu Gly Ala Arg Gly Ala His Met Leu 
                485                 490                 495     


Leu Gln Asn Glu Leu Phe Leu Asn Val Gly Thr Lys Asp Phe Pro Asp 
            500                 505                 510         


Gly Glu Leu Arg Gly His Val Ala Ala Leu Pro Tyr Cys Gly His Ser 
        515                 520                 525             


Ala Arg His Asp Thr Leu Pro Val Pro Leu Ala Gly Ala Leu Val Leu 
    530                 535                 540                 


Pro Pro Val Lys Ser Gln Ala Ala Gly His Ala Trp Leu Ser Leu Asp 
545                 550                 555                 560 


Thr His Cys His Leu His Tyr Glu Val Leu Leu Ala Gly Leu Gly Gly 
                565                 570                 575     


Ser Glu Gln Gly Thr Val Thr Ala His Leu Leu Gly Pro Pro Gly Thr 
            580                 585                 590         


Pro Gly Pro Arg Arg Leu Leu Lys Gly Phe Tyr Gly Ser Glu Ala Gln 
        595                 600                 605             


Gly Val Val Lys Asp Leu Glu Pro Glu Leu Leu Arg His Leu Ala Lys 
    610                 615                 620                 


Gly Met Ala Ser Leu Met Ile Thr Thr Lys Gly Ser Pro Arg Gly Glu 
625                 630                 635                 640 


Leu Arg Gly Gln Val His Ile Ala Asn Gln Cys Glu Val Gly Gly Leu 
                645                 650                 655     


Arg Leu Glu Ala Ala Gly Ala Glu Gly Val Arg Ala Leu Gly Ala Pro 
            660                 665                 670         


Asp Thr Ala Ser Ala Ala Pro Pro Val Val Pro Gly Leu Pro Ala Leu 
        675                 680                 685             


Ala Pro Ala Lys Pro Gly Gly Pro Gly Arg Pro Arg Asp Pro Asn Thr 
    690                 695                 700                 


Cys Phe Phe Glu Gly Gln Gln Arg Pro His Gly Ala Arg Trp Ala Pro 
705                 710                 715                 720 


Asn Tyr Asp Pro Leu Cys Ser Leu Cys Thr Cys Gln Arg Arg Thr Val 
                725                 730                 735     


Ile Cys Asp Pro Val Val Cys Pro Pro Pro Ser Cys Pro His Pro Val 
            740                 745                 750         


Gln Ala Pro Asp Gln Cys Cys Pro Val Cys Pro Glu Lys Gln Asp Val 
        755                 760                 765             


Arg Asp Leu Pro Gly Leu Pro Arg Ser Arg Asp Pro Gly Glu Gly Cys 
    770                 775                 780                 


Tyr Phe Asp Gly Asp Arg Ser Trp Arg Ala Ala Gly Thr Arg Trp His 
785                 790                 795                 800 


Pro Val Val Pro Pro Phe Gly Leu Ile Lys Cys Ala Val Cys Thr Cys 
                805                 810                 815     


Lys Gly Gly Thr Gly Glu Val His Cys Glu Lys Val Gln Cys Pro Arg 
            820                 825                 830         


Leu Ala Cys Ala Gln Pro Val Arg Val Asn Pro Thr Asp Cys Cys Lys 
        835                 840                 845             


Gln Cys Pro Val Gly Ser Gly Ala His Pro Gln Leu Gly Asp Pro Met 
    850                 855                 860                 


Gln Ala Asp Gly Pro Arg Gly Cys Arg Phe Ala Gly Gln Trp Phe Pro 
865                 870                 875                 880 


Glu Ser Gln Ser Trp His Pro Ser Val Pro Pro Phe Gly Glu Met Ser 
                885                 890                 895     


Cys Ile Thr Cys Arg Cys Gly Ala Gly Val Pro His Cys Glu Arg Asp 
            900                 905                 910         


Asp Cys Ser Leu Pro Leu Ser Cys Gly Ser Gly Lys Glu Ser Arg Cys 
        915                 920                 925             


Cys Ser Arg Cys Thr Ala His Arg Arg Pro Pro Glu Thr Arg Thr Asp 
    930                 935                 940                 


Pro Glu Leu Glu Lys Glu Ala Glu Gly Ser 
945                 950                 


<210>  2152
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRDL1__Homo_sapiens__NP_001137455

<400>  2152

Met Arg Lys Lys Trp Lys Met Gly Gly Met Lys Tyr Ile Phe Ser Leu 
1               5                   10                  15      


Leu Phe Phe Leu Leu Leu Glu Gly Gly Lys Thr Glu Gln Val Lys His 
            20                  25                  30          


Ser Glu Thr Tyr Cys Met Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu 
        35                  40                  45              


Arg Trp His Pro Tyr Leu Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn 
    50                  55                  60                  


Cys Ile Cys Ser Glu Asn Gly Asn Val Leu Cys Ser Arg Val Arg Cys 
65                  70                  75                  80  


Pro Asn Val His Cys Leu Ser Pro Val His Ile Pro His Leu Cys Cys 
                85                  90                  95      


Pro Arg Cys Pro Gly Asp Gly Glu Leu Ser Trp Glu His Ser Asp Gly 
            100                 105                 110         


Asp Ile Phe Arg Gln Pro Ala Asn Arg Glu Ala Arg His Ser Tyr His 
        115                 120                 125             


Arg Ser His Tyr Asp Pro Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser 
    130                 135                 140                 


Arg Phe Pro Gly Ala Arg Ser His Arg Gly Ala Leu Met Asp Ser Gln 
145                 150                 155                 160 


Gln Ala Ser Gly Thr Ile Val Gln Ile Val Ile Asn Asn Lys His Lys 
                165                 170                 175     


His Gly Gln Val Cys Val Ser Asn Gly Lys Thr Tyr Ser His Gly Glu 
            180                 185                 190         


Ser Trp His Pro Asn Leu Arg Ala Phe Gly Ile Val Glu Cys Val Leu 
        195                 200                 205             


Cys Thr Cys Asn Val Thr Lys Gln Glu Cys Lys Lys Ile His Cys Pro 
    210                 215                 220                 


Asn Arg Tyr Pro Cys Lys Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys 
225                 230                 235                 240 


Lys Val Cys Pro Gly Lys Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser 
                245                 250                 255     


Phe Asp Asn Lys Gly Tyr Phe Cys Gly Glu Glu Thr Met Pro Val Tyr 
            260                 265                 270         


Glu Ser Val Phe Met Glu Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu 
        275                 280                 285             


Glu Thr Glu Arg Pro Pro Gln Val Glu Val His Val Trp Thr Ile Arg 
    290                 295                 300                 


Lys Gly Ile Leu Gln His Phe His Ile Glu Lys Ile Ser Lys Arg Met 
305                 310                 315                 320 


Phe Glu Glu Leu Pro His Phe Lys Leu Val Thr Arg Thr Thr Leu Ser 
                325                 330                 335     


Gln Trp Lys Ile Phe Thr Glu Gly Glu Ala Gln Ile Ser Gln Met Cys 
            340                 345                 350         


Ser Ser Arg Val Cys Arg Thr Glu Leu Glu Asp Leu Val Lys Val Leu 
        355                 360                 365             


Tyr Leu Glu Arg Ser Glu Lys Gly His Cys 
    370                 375             


<210>  2153
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRFAM7A__Homo_sapiens__XP_011520455

<400>  2153

Met Gln Lys Tyr Cys Ile Tyr Gln His Phe Gln Phe Gln Leu Leu Ile 
1               5                   10                  15      


Gln His Leu Trp Ile Ala Ala Asn Cys Asp Ile Ala Asp Glu Arg Phe 
            20                  25                  30          


Asp Ala Thr Phe His Thr Asn Val Leu Val Asn Ser Ser Gly His Cys 
        35                  40                  45              


Gln Tyr Leu Pro Pro Gly Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val 
    50                  55                  60                  


Arg Trp Phe Pro Phe Asp Val Gln His Cys Lys Leu Lys Phe Gly Ser 
65                  70                  75                  80  


Trp Ser Tyr Gly Gly Trp Ser Leu Asp Leu Gln Met Gln Glu Ala Asp 
                85                  90                  95      


Ile Ser Gly Tyr Ile Pro Asn Gly Glu Trp Asp Leu Val Gly Ile Pro 
            100                 105                 110         


Gly Lys Arg Ser Glu Arg Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro 
        115                 120                 125             


Asp Val Thr Phe Thr Val Thr Met Arg Arg Arg Thr Leu Tyr Tyr Gly 
    130                 135                 140                 


Leu Asn Leu Leu Ile Pro Cys Val Leu Ile Ser Ala Leu Ala Leu Leu 
145                 150                 155                 160 


Val Phe Leu Leu Pro Ala Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile 
                165                 170                 175     


Thr Val Leu Leu Ser Leu Thr Val Phe Met Leu Leu Val Ala Glu Ile 
            180                 185                 190         


Met Pro Ala Thr Ser Asp Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala 
        195                 200                 205             


Ser Thr Met Ile Ile Val Gly Leu Ser Val Val Val Thr Val Ile Val 
    210                 215                 220                 


Leu Gln Tyr His His His Asp Pro Asp Gly Gly Lys Met Pro Lys Trp 
225                 230                 235                 240 


Thr Arg Val Ile Leu Leu Asn Trp Cys Ala Trp Phe Leu Arg Met Lys 
                245                 250                 255     


Arg Pro Gly Glu Asp Lys Val Arg Pro Ala Cys Gln His Lys Gln Arg 
            260                 265                 270         


Arg Cys Ser Leu Ala Ser Val Glu Met Ser Ala Val Ala Pro Pro Pro 
        275                 280                 285             


Ala Ser Asn Gly Asn Leu Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly 
    290                 295                 300                 


Val His Cys Val Pro Thr Pro Asp Ser Gly Val Val Cys Gly Arg Met 
305                 310                 315                 320 


Ala Cys Ser Pro Thr His Asp Glu His Leu Leu His Gly Gly Gln Pro 
                325                 330                 335     


Pro Glu Gly Asp Pro Asp Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr 
            340                 345                 350         


Ile Ala Asn Arg Phe Arg Cys Gln Asp Glu Ser Glu Ala Val Cys Ser 
        355                 360                 365             


Glu Trp Lys Phe Ala Ala Cys Val Val Asp Arg Leu Cys Leu Met Ala 
    370                 375                 380                 


Phe Ser Val Phe Thr Ile Ile Cys Thr Ile Gly Ile Leu Met Ser Ala 
385                 390                 395                 400 


Pro Asn Phe Val Glu Ala Val Ser Lys Asp Phe Ala 
                405                 410         


<210>  2154
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRM1__Homo_sapiens__XP_011543044

<400>  2154

Met Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Thr Thr 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Thr Val Thr Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Thr Glu Leu Lys Thr Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Thr Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Thr Thr Tyr Leu Leu Met Gly His Trp Ala Leu Gly Thr Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Thr 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg Ala Lys Arg Thr Pro Arg Arg Ala Ala Leu 
    130                 135                 140                 


Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 
145                 150                 155                 160 


Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Thr Val Leu Ala Gly 
                165                 170                 175     


Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Thr Phe Gly Thr 
            180                 185                 190         


Ala Met Ala Ala Phe Tyr Leu Pro Val Thr Val Met Cys Thr Leu Tyr 
        195                 200                 205             


Trp Arg Ile Tyr Arg Glu Thr Glu Asn Arg Ala Arg Glu Leu Ala Ala 
    210                 215                 220                 


Leu Gln Gly Ser Glu Thr Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Thr Pro Pro 
                245                 250                 255     


Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 
            260                 265                 270         


Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 
        275                 280                 285             


Thr Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 
    290                 295                 300                 


Pro Met Val Asp Pro Glu Ala Gln Ala Pro Thr Lys Gln Pro Pro Arg 
305                 310                 315                 320 


Ser Ser Pro Asn Thr Val Lys Arg Pro Thr Lys Lys Gly Arg Asp Arg 
                325                 330                 335     


Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 
            340                 345                 350         


Lys Thr Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Thr Leu Ser 
        355                 360                 365             


Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr Asn Ile Met 
    370                 375                 380                 


Val Leu Val Ser Thr Phe Cys Lys Asp Cys Val Pro Glu Thr Leu Trp 
385                 390                 395                 400 


Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Met 
                405                 410                 415     


Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Thr Phe Arg Leu Leu 
            420                 425                 430         


Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 
        435                 440                 445             


Pro Gly Ser Val His Arg Thr Pro Ser Arg Gln Cys 
    450                 455                 460 


<210>  2155
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRM2__Homo_sapiens__XP_011514073

<400>  2155

Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210>  2156
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRM3__Homo_sapiens__NP_000731

<400>  2156

Met Thr Leu His Asn Asn Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile 
1               5                   10                  15      


Ser Ser Ser Trp Ile His Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly 
            20                  25                  30          


Thr Val Thr His Phe Gly Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn 
        35                  40                  45              


Phe Ser Ser Pro Asp Gly Thr Thr Asp Asp Pro Leu Gly Gly His Thr 
    50                  55                  60                  


Val Trp Gln Val Val Phe Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu 
65                  70                  75                  80  


Val Thr Ile Ile Gly Asn Ile Leu Val Ile Val Ser Phe Lys Val Asn 
                85                  90                  95      


Lys Gln Leu Lys Thr Val Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys 
            100                 105                 110         


Ala Asp Leu Ile Ile Gly Val Ile Ser Met Asn Leu Phe Thr Thr Tyr 
        115                 120                 125             


Ile Ile Met Asn Arg Trp Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp 
    130                 135                 140                 


Leu Ala Ile Asp Tyr Val Ala Ser Asn Ala Ser Val Met Asn Leu Leu 
145                 150                 155                 160 


Val Ile Ser Phe Asp Arg Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr 
                165                 170                 175     


Arg Ala Lys Arg Thr Thr Lys Arg Ala Gly Val Met Ile Gly Leu Ala 
            180                 185                 190         


Trp Val Ile Ser Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln 
        195                 200                 205             


Tyr Phe Val Gly Lys Arg Thr Val Pro Pro Gly Glu Cys Phe Ile Gln 
    210                 215                 220                 


Phe Leu Ser Glu Pro Thr Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe 
225                 230                 235                 240 


Tyr Met Pro Val Thr Ile Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys 
                245                 250                 255     


Glu Thr Glu Lys Arg Thr Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly 
            260                 265                 270         


Thr Glu Ala Glu Thr Glu Asn Phe Val His Pro Thr Gly Ser Ser Arg 
        275                 280                 285             


Ser Cys Ser Ser Tyr Glu Leu Gln Gln Gln Ser Met Lys Arg Ser Asn 
    290                 295                 300                 


Arg Arg Lys Tyr Gly Arg Cys His Phe Trp Phe Thr Thr Lys Ser Trp 
305                 310                 315                 320 


Lys Pro Ser Ser Glu Gln Met Asp Gln Asp His Ser Ser Ser Asp Ser 
                325                 330                 335     


Trp Asn Asn Asn Asp Ala Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser 
            340                 345                 350         


Asp Glu Glu Asp Ile Gly Ser Glu Thr Arg Ala Ile Tyr Ser Ile Val 
        355                 360                 365             


Leu Lys Leu Pro Gly His Ser Thr Ile Leu Asn Ser Thr Lys Leu Pro 
    370                 375                 380                 


Ser Ser Asp Asn Leu Gln Val Pro Glu Glu Glu Leu Gly Met Val Asp 
385                 390                 395                 400 


Leu Glu Arg Lys Ala Asp Lys Leu Gln Ala Gln Lys Ser Val Asp Asp 
                405                 410                 415     


Gly Gly Ser Phe Pro Lys Ser Phe Ser Lys Leu Pro Ile Gln Leu Glu 
            420                 425                 430         


Ser Ala Val Asp Thr Ala Lys Thr Ser Asp Val Asn Ser Ser Val Gly 
        435                 440                 445             


Lys Ser Thr Ala Thr Leu Pro Leu Ser Phe Lys Glu Ala Thr Leu Ala 
    450                 455                 460                 


Lys Arg Phe Ala Leu Lys Thr Arg Ser Gln Ile Thr Lys Arg Lys Arg 
465                 470                 475                 480 


Met Ser Leu Val Lys Glu Lys Lys Ala Ala Gln Thr Leu Ser Ala Ile 
                485                 490                 495     


Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val Leu 
            500                 505                 510         


Val Asn Thr Phe Cys Asp Ser Cys Ile Pro Lys Thr Phe Trp Asn Leu 
        515                 520                 525             


Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr Val Asn Pro Val Cys Tyr 
    530                 535                 540                 


Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr Phe Lys Met Leu Leu Leu 
545                 550                 555                 560 


Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys Gln Gln Tyr Gln Gln Arg 
                565                 570                 575     


Gln Ser Val Ile Phe His Lys Arg Ala Pro Glu Gln Ala Leu 
            580                 585                 590 


<210>  2157
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRM4__Homo_sapiens__NP_000732

<400>  2157

Met Ala Asn Phe Thr Pro Val Asn Gly Ser Ser Gly Asn Gln Ser Val 
1               5                   10                  15      


Arg Leu Val Thr Ser Ser Ser His Asn Arg Tyr Glu Thr Val Glu Met 
            20                  25                  30          


Val Phe Ile Ala Thr Val Thr Gly Ser Leu Ser Leu Val Thr Val Val 
        35                  40                  45              


Gly Asn Ile Leu Val Met Leu Ser Ile Lys Val Asn Arg Gln Leu Gln 
    50                  55                  60                  


Thr Val Asn Asn Tyr Phe Leu Phe Ser Leu Ala Cys Ala Asp Leu Ile 
65                  70                  75                  80  


Ile Gly Ala Phe Ser Met Asn Leu Tyr Thr Val Tyr Ile Ile Lys Gly 
                85                  90                  95      


Tyr Trp Pro Leu Gly Ala Val Val Cys Asp Leu Trp Leu Ala Leu Asp 
            100                 105                 110         


Tyr Val Val Ser Asn Ala Ser Val Met Asn Leu Leu Ile Ile Ser Phe 
        115                 120                 125             


Asp Arg Tyr Phe Cys Val Thr Lys Pro Leu Thr Tyr Pro Ala Arg Arg 
    130                 135                 140                 


Thr Thr Lys Met Ala Gly Leu Met Ile Ala Ala Ala Trp Val Leu Ser 
145                 150                 155                 160 


Phe Val Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Phe Val Val Gly 
                165                 170                 175     


Lys Arg Thr Val Pro Asp Asn Gln Cys Phe Ile Gln Phe Leu Ser Asn 
            180                 185                 190         


Pro Ala Val Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Leu Pro Val 
        195                 200                 205             


Val Ile Met Thr Val Leu Tyr Ile His Ile Ser Leu Ala Ser Arg Ser 
    210                 215                 220                 


Arg Val His Lys His Arg Pro Glu Gly Pro Lys Glu Lys Lys Ala Lys 
225                 230                 235                 240 


Thr Leu Ala Phe Leu Lys Ser Pro Leu Met Lys Gln Ser Val Lys Lys 
                245                 250                 255     


Pro Pro Pro Gly Glu Ala Ala Arg Glu Glu Leu Arg Asn Gly Lys Leu 
            260                 265                 270         


Glu Glu Ala Pro Pro Pro Ala Leu Pro Pro Pro Pro Arg Pro Val Ala 
        275                 280                 285             


Asp Lys Asp Thr Ser Asn Glu Ser Ser Ser Gly Ser Ala Thr Gln Asn 
    290                 295                 300                 


Thr Lys Glu Arg Pro Ala Thr Glu Leu Ser Thr Thr Glu Ala Thr Thr 
305                 310                 315                 320 


Pro Ala Met Pro Ala Pro Pro Leu Gln Pro Arg Ala Leu Asn Pro Ala 
                325                 330                 335     


Ser Arg Trp Ser Lys Ile Gln Ile Val Thr Lys Gln Thr Gly Asn Glu 
            340                 345                 350         


Cys Val Thr Ala Ile Glu Ile Val Pro Ala Thr Pro Ala Gly Met Arg 
        355                 360                 365             


Pro Ala Ala Asn Val Ala Arg Lys Phe Ala Ser Ile Ala Arg Asn Gln 
    370                 375                 380                 


Val Arg Lys Lys Arg Gln Met Ala Ala Arg Glu Arg Lys Val Thr Arg 
385                 390                 395                 400 


Thr Ile Phe Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr 
                405                 410                 415     


Asn Val Met Val Leu Val Asn Thr Phe Cys Gln Ser Cys Ile Pro Asp 
            420                 425                 430         


Thr Val Trp Ser Ile Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile 
        435                 440                 445             


Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys Lys Thr Phe 
    450                 455                 460                 


Arg His Leu Leu Leu Cys Gln Tyr Arg Asn Ile Gly Thr Ala Arg 
465                 470                 475                 


<210>  2158
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRM5__Homo_sapiens__XP_005254198

<400>  2158

Met Glu Gly Asp Ser Tyr His Asn Ala Thr Thr Val Asn Gly Thr Pro 
1               5                   10                  15      


Val Asn His Gln Pro Leu Glu Arg His Arg Leu Trp Glu Val Ile Thr 
            20                  25                  30          


Ile Ala Ala Val Thr Ala Val Val Ser Leu Ile Thr Ile Val Gly Asn 
        35                  40                  45              


Val Leu Val Met Ile Ser Phe Lys Val Asn Ser Gln Leu Lys Thr Val 
    50                  55                  60                  


Asn Asn Tyr Tyr Leu Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly 
65                  70                  75                  80  


Ile Phe Ser Met Asn Leu Tyr Thr Thr Tyr Ile Leu Met Gly Arg Trp 
                85                  90                  95      


Ala Leu Gly Ser Leu Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val 
            100                 105                 110         


Ala Ser Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg 
        115                 120                 125             


Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr Arg Ala Lys Arg Thr Pro 
    130                 135                 140                 


Lys Arg Ala Gly Ile Met Ile Gly Leu Ala Trp Leu Ile Ser Phe Ile 
145                 150                 155                 160 


Leu Trp Ala Pro Ala Ile Leu Cys Trp Gln Tyr Leu Val Gly Lys Arg 
                165                 170                 175     


Thr Val Pro Leu Asp Glu Cys Gln Ile Gln Phe Leu Ser Glu Pro Thr 
            180                 185                 190         


Ile Thr Phe Gly Thr Ala Ile Ala Ala Phe Tyr Ile Pro Val Ser Val 
        195                 200                 205             


Met Thr Ile Leu Tyr Cys Arg Ile Tyr Arg Glu Thr Glu Lys Arg Thr 
    210                 215                 220                 


Lys Asp Leu Ala Asp Leu Gln Gly Ser Asp Ser Val Thr Lys Ala Glu 
225                 230                 235                 240 


Lys Arg Lys Pro Ala His Arg Ala Leu Phe Arg Ser Cys Leu Arg Cys 
                245                 250                 255     


Pro Arg Pro Thr Leu Ala Gln Arg Glu Arg Asn Gln Ala Ser Trp Ser 
            260                 265                 270         


Ser Ser Arg Arg Ser Thr Ser Thr Thr Gly Lys Pro Ser Gln Ala Thr 
        275                 280                 285             


Gly Pro Ser Ala Asn Trp Ala Lys Ala Glu Gln Leu Thr Thr Cys Ser 
    290                 295                 300                 


Ser Tyr Pro Ser Ser Glu Asp Glu Asp Lys Pro Ala Thr Asp Pro Val 
305                 310                 315                 320 


Leu Gln Val Val Tyr Lys Ser Gln Gly Lys Glu Ser Pro Gly Glu Glu 
                325                 330                 335     


Phe Ser Ala Glu Glu Thr Glu Glu Thr Phe Val Lys Ala Glu Thr Glu 
            340                 345                 350         


Lys Ser Asp Tyr Asp Thr Pro Asn Tyr Leu Leu Ser Pro Ala Ala Ala 
        355                 360                 365             


His Arg Pro Lys Ser Gln Lys Cys Val Ala Tyr Lys Phe Arg Leu Val 
    370                 375                 380                 


Val Lys Ala Asp Gly Asn Gln Glu Thr Asn Asn Gly Cys His Lys Val 
385                 390                 395                 400 


Lys Ile Met Pro Cys Pro Phe Pro Val Ala Lys Glu Pro Ser Thr Lys 
                405                 410                 415     


Gly Leu Asn Pro Asn Pro Ser His Gln Met Thr Lys Arg Lys Arg Val 
            420                 425                 430         


Val Leu Val Lys Glu Arg Lys Ala Ala Gln Thr Leu Ser Ala Ile Leu 
        435                 440                 445             


Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val Leu Val 
    450                 455                 460                 


Ser Thr Phe Cys Asp Lys Cys Val Pro Val Thr Leu Trp His Leu Gly 
465                 470                 475                 480 


Tyr Trp Leu Cys Tyr Val Asn Ser Thr Val Asn Pro Ile Cys Tyr Ala 
                485                 490                 495     


Leu Cys Asn Arg Thr Phe Arg Lys Thr Phe Lys Met Leu Leu Leu Cys 
            500                 505                 510         


Arg Trp Lys Lys Lys Lys Val Glu Glu Lys Leu Tyr Trp Gln Gly Asn 
        515                 520                 525             


Ser Lys Leu Pro 
    530         


<210>  2159
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA10__Homo_sapiens__NP_065135

<400>  2159

Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg Leu Ala Leu Lys 
            20                  25                  30          


Leu Phe Arg Asp Leu Phe Ala Asn Tyr Thr Ser Ala Leu Arg Pro Val 
        35                  40                  45              


Ala Asp Thr Asp Gln Thr Leu Asn Val Thr Leu Glu Val Thr Leu Ser 
    50                  55                  60                  


Gln Ile Ile Asp Met Asp Glu Arg Asn Gln Val Leu Thr Leu Tyr Leu 
65                  70                  75                  80  


Trp Ile Arg Gln Glu Trp Thr Asp Ala Tyr Leu Arg Trp Asp Pro Asn 
                85                  90                  95      


Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro Ser Ser Leu Val Trp 
            100                 105                 110         


Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Ala Gln Pro Pro Gly 
        115                 120                 125             


Ser Ala Ser Thr Asn Val Val Leu Arg His Asp Gly Ala Val Arg Trp 
    130                 135                 140                 


Asp Ala Pro Ala Ile Thr Arg Ser Ser Cys Arg Val Asp Val Ala Ala 
145                 150                 155                 160 


Phe Pro Phe Asp Ala Gln His Cys Gly Leu Thr Phe Gly Ser Trp Thr 
                165                 170                 175     


His Gly Gly His Gln Leu Asp Val Arg Pro Arg Gly Ala Ala Ala Ser 
            180                 185                 190         


Leu Ala Asp Phe Val Glu Asn Val Glu Trp Arg Val Leu Gly Met Pro 
        195                 200                 205             


Ala Arg Arg Arg Val Leu Thr Tyr Gly Cys Cys Ser Glu Pro Tyr Pro 
    210                 215                 220                 


Asp Val Thr Phe Thr Leu Leu Leu Arg Arg Arg Ala Ala Ala Tyr Val 
225                 230                 235                 240 


Cys Asn Leu Leu Leu Pro Cys Val Leu Ile Ser Leu Leu Ala Pro Leu 
                245                 250                 255     


Ala Phe His Leu Pro Ala Asp Ser Gly Glu Lys Val Ser Leu Gly Val 
            260                 265                 270         


Thr Val Leu Leu Ala Leu Thr Val Phe Gln Leu Leu Leu Ala Glu Ser 
        275                 280                 285             


Met Pro Pro Ala Glu Ser Val Pro Leu Ile Gly Lys Tyr Tyr Met Ala 
    290                 295                 300                 


Thr Met Thr Met Val Thr Phe Ser Thr Ala Leu Thr Ile Leu Ile Met 
305                 310                 315                 320 


Asn Leu His Tyr Cys Gly Pro Ser Val Arg Pro Val Pro Ala Trp Ala 
                325                 330                 335     


Arg Ala Leu Leu Leu Gly His Leu Ala Arg Gly Leu Cys Val Arg Glu 
            340                 345                 350         


Arg Gly Glu Pro Cys Gly Gln Ser Arg Pro Pro Glu Leu Ser Pro Ser 
        355                 360                 365             


Pro Gln Ser Pro Glu Gly Gly Ala Gly Pro Pro Ala Gly Pro Cys His 
    370                 375                 380                 


Glu Pro Arg Cys Leu Cys Arg Gln Glu Ala Leu Leu His His Val Ala 
385                 390                 395                 400 


Thr Ile Ala Asn Thr Phe Arg Ser His Arg Ala Ala Gln Arg Cys His 
                405                 410                 415     


Glu Asp Trp Lys Arg Leu Ala Arg Val Met Asp Arg Phe Phe Leu Ala 
            420                 425                 430         


Ile Phe Phe Ser Met Ala Leu Val Met Ser Leu Leu Val Leu Val Gln 
        435                 440                 445             


Ala Leu 
    450 


<210>  2160
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA1__Homo_sapiens__NP_000070

<400>  2160

Met Glu Pro Trp Pro Leu Leu Leu Leu Phe Ser Leu Cys Ser Ala Gly 
1               5                   10                  15      


Leu Val Leu Gly Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe 
            20                  25                  30          


Lys Asp Tyr Ser Ser Val Val Arg Pro Val Glu Asp His Arg Gln Val 
        35                  40                  45              


Val Glu Val Thr Val Gly Leu Gln Leu Ile Gln Leu Ile Asn Val Asp 
    50                  55                  60                  


Glu Val Asn Gln Ile Val Thr Thr Asn Val Arg Leu Lys Gln Gln Trp 
65                  70                  75                  80  


Val Asp Tyr Asn Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
                85                  90                  95      


Lys Ile His Ile Pro Ser Glu Lys Ile Trp Arg Pro Asp Leu Val Leu 
            100                 105                 110         


Tyr Asn Asn Ala Asp Gly Asp Phe Ala Ile Val Lys Phe Thr Lys Val 
        115                 120                 125             


Leu Leu Gln Tyr Thr Gly His Ile Thr Trp Thr Pro Pro Ala Ile Phe 
    130                 135                 140                 


Lys Ser Tyr Cys Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln 
145                 150                 155                 160 


Asn Cys Ser Met Lys Leu Gly Thr Trp Thr Tyr Asp Gly Ser Val Val 
                165                 170                 175     


Ala Ile Asn Pro Glu Ser Asp Gln Pro Asp Leu Ser Asn Phe Met Glu 
            180                 185                 190         


Ser Gly Glu Trp Val Ile Lys Glu Ser Arg Gly Trp Lys His Ser Val 
        195                 200                 205             


Thr Tyr Ser Cys Cys Pro Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His 
    210                 215                 220                 


Phe Val Met Gln Arg Leu Pro Leu Tyr Phe Ile Val Asn Val Ile Ile 
225                 230                 235                 240 


Pro Cys Leu Leu Phe Ser Phe Leu Thr Gly Leu Val Phe Tyr Leu Pro 
                245                 250                 255     


Thr Asp Ser Gly Glu Lys Met Thr Leu Ser Ile Ser Val Leu Leu Ser 
            260                 265                 270         


Leu Thr Val Phe Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser 
        275                 280                 285             


Ser Ala Val Pro Leu Ile Gly Lys Tyr Met Leu Phe Thr Met Val Phe 
    290                 295                 300                 


Val Ile Ala Ser Ile Ile Ile Thr Val Ile Val Ile Asn Thr His His 
305                 310                 315                 320 


Arg Ser Pro Ser Thr His Val Met Pro Asn Trp Val Arg Lys Val Phe 
                325                 330                 335     


Ile Asp Thr Ile Pro Asn Ile Met Phe Phe Ser Thr Met Lys Arg Pro 
            340                 345                 350         


Ser Arg Glu Lys Gln Asp Lys Lys Ile Phe Thr Glu Asp Ile Asp Ile 
        355                 360                 365             


Ser Asp Ile Ser Gly Lys Pro Gly Pro Pro Pro Met Gly Phe His Ser 
    370                 375                 380                 


Pro Leu Ile Lys His Pro Glu Val Lys Ser Ala Ile Glu Gly Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Glu Thr Met Lys Ser Asp Gln Glu Ser Asn Asn Ala Ala 
                405                 410                 415     


Ala Glu Trp Lys Tyr Val Ala Met Val Met Asp His Ile Leu Leu Gly 
            420                 425                 430         


Val Phe Met Leu Val Cys Ile Ile Gly Thr Leu Ala Val Phe Ala Gly 
        435                 440                 445             


Arg Leu Ile Glu Leu Asn Gln Gln Gly 
    450                 455         


<210>  2161
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA2__Homo_sapiens__NP_000733

<400>  2161

Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu 
1               5                   10                  15      


Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro 
            20                  25                  30          


Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala 
        35                  40                  45              


Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys 
    50                  55                  60                  


His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr 
65                  70                  75                  80  


Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile 
                85                  90                  95      


Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn Val Trp Leu Lys 
            100                 105                 110         


Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Thr Asp Phe Gly 
        115                 120                 125             


Asn Ile Thr Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp 
    130                 135                 140                 


Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Thr His Met 
145                 150                 155                 160 


Thr Lys Ala His Leu Phe Ser Thr Gly Thr Val His Trp Val Pro Pro 
                165                 170                 175     


Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Thr Phe Phe Pro Phe 
            180                 185                 190         


Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys 
        195                 200                 205             


Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Thr Val Asp Leu Lys Asp 
    210                 215                 220                 


Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Thr Gly Thr Tyr 
225                 230                 235                 240 


Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val Thr 
                245                 250                 255     


Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu 
            260                 265                 270         


Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Thr Val Leu Val Phe Tyr 
        275                 280                 285             


Leu Pro Ser Asp Cys Gly Glu Lys Ile Thr Leu Cys Ile Ser Val Leu 
    290                 295                 300                 


Leu Ser Leu Thr Val Phe Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser 
305                 310                 315                 320 


Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met 
                325                 330                 335     


Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu Asn Val 
            340                 345                 350         


His His Arg Ser Pro Ser Thr His Thr Met Pro His Trp Val Arg Gly 
        355                 360                 365             


Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro Pro 
    370                 375                 380                 


Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro Ser 
385                 390                 395                 400 


Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val Val 
                405                 410                 415     


Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro Ser 
            420                 425                 430         


Val Gly Thr Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser Gly 
        435                 440                 445             


Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro 
    450                 455                 460                 


His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His Leu 
465                 470                 475                 480 


Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr Val 
                485                 490                 495     


Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val Cys 
            500                 505                 510         


Phe Leu Gly Thr Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly Met 
        515                 520                 525             


Ile 
    


<210>  2162
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA3__Homo_sapiens__NP_000734

<400>  2162

Met Gly Ser Gly Pro Leu Ser Leu Pro Leu Ala Leu Ser Pro Pro Arg 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Ser Leu Leu Pro Val Ala Arg Ala Ser 
            20                  25                  30          


Glu Ala Glu His Arg Leu Phe Glu Arg Leu Phe Glu Asp Tyr Asn Glu 
        35                  40                  45              


Ile Ile Arg Pro Val Ala Asn Val Ser Asp Pro Val Ile Ile His Phe 
    50                  55                  60                  


Glu Val Ser Met Ser Gln Leu Val Lys Val Asp Glu Val Asn Gln Ile 
65                  70                  75                  80  


Met Glu Thr Asn Leu Trp Leu Lys Gln Ile Trp Asn Asp Tyr Lys Leu 
                85                  90                  95      


Lys Trp Asn Pro Ser Asp Tyr Gly Gly Ala Glu Phe Met Arg Val Pro 
            100                 105                 110         


Ala Gln Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
        115                 120                 125             


Gly Asp Phe Gln Val Asp Asp Lys Thr Lys Ala Leu Leu Lys Tyr Thr 
    130                 135                 140                 


Gly Glu Val Thr Trp Ile Pro Pro Ala Ile Phe Lys Ser Ser Cys Lys 
145                 150                 155                 160 


Ile Asp Val Thr Tyr Phe Pro Phe Asp Tyr Gln Asn Cys Thr Met Lys 
                165                 170                 175     


Phe Gly Ser Trp Ser Tyr Asp Lys Ala Lys Ile Asp Leu Val Leu Ile 
            180                 185                 190         


Gly Ser Ser Met Asn Leu Lys Asp Tyr Trp Glu Ser Gly Glu Trp Ala 
        195                 200                 205             


Ile Ile Lys Ala Pro Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
    210                 215                 220                 


Glu Glu Ile Tyr Pro Asp Ile Thr Tyr Ser Leu Tyr Ile Arg Arg Leu 
225                 230                 235                 240 


Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu Ile Ser 
                245                 250                 255     


Phe Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
            260                 265                 270         


Val Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu 
        275                 280                 285             


Val Ile Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Ile Pro Leu Ile 
    290                 295                 300                 


Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val 
305                 310                 315                 320 


Ile Thr Val Phe Val Leu Asn Val His Tyr Arg Thr Pro Thr Thr His 
                325                 330                 335     


Thr Met Pro Ser Trp Val Lys Thr Val Phe Leu Asn Leu Leu Pro Arg 
            340                 345                 350         


Val Met Phe Met Thr Arg Pro Thr Ser Asn Glu Gly Asn Ala Gln Lys 
        355                 360                 365             


Pro Arg Pro Leu Tyr Gly Ala Glu Leu Ser Asn Leu Asn Cys Phe Ser 
    370                 375                 380                 


Arg Ala Glu Ser Lys Gly Cys Lys Glu Gly Tyr Pro Cys Gln Asp Gly 
385                 390                 395                 400 


Met Cys Gly Tyr Cys His His Arg Arg Ile Lys Ile Ser Asn Phe Ser 
                405                 410                 415     


Ala Asn Leu Thr Arg Ser Ser Ser Ser Glu Ser Val Asp Ala Val Leu 
            420                 425                 430         


Ser Leu Ser Ala Leu Ser Pro Glu Ile Lys Glu Ala Ile Gln Ser Val 
        435                 440                 445             


Lys Tyr Ile Ala Glu Asn Met Lys Ala Gln Asn Glu Ala Lys Glu Ile 
    450                 455                 460                 


Gln Asp Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu 
465                 470                 475                 480 


Trp Val Phe Thr Leu Val Cys Ile Leu Gly Thr Ala Gly Leu Phe Leu 
                485                 490                 495     


Gln Pro Leu Met Ala Arg Glu Asp Ala 
            500                 505 


<210>  2163
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA4__Homo_sapiens__NP_000735

<400>  2163

Met Glu Leu Gly Gly Pro Gly Ala Pro Arg Leu Leu Pro Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Thr Gly Leu Leu Arg Ala Ser Ser His Val Glu Thr 
            20                  25                  30          


Arg Ala His Ala Glu Glu Arg Leu Leu Lys Lys Leu Phe Ser Gly Tyr 
        35                  40                  45              


Asn Lys Trp Ser Arg Pro Val Ala Asn Ile Ser Asp Val Val Leu Val 
    50                  55                  60                  


Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile Asp Val Asp Glu Lys Asn 
65                  70                  75                  80  


Gln Met Met Thr Thr Asn Val Trp Val Lys Gln Glu Trp His Asp Tyr 
                85                  90                  95      


Lys Leu Arg Trp Asp Pro Ala Asp Tyr Glu Asn Val Thr Ser Ile Arg 
            100                 105                 110         


Ile Pro Ser Glu Leu Ile Trp Arg Pro Asp Ile Val Leu Tyr Asn Asn 
        115                 120                 125             


Ala Asp Gly Asp Phe Ala Val Thr His Leu Thr Lys Ala His Leu Phe 
    130                 135                 140                 


His Asp Gly Arg Val Gln Trp Thr Pro Pro Ala Ile Tyr Lys Ser Ser 
145                 150                 155                 160 


Cys Ser Ile Asp Val Thr Phe Phe Pro Phe Asp Gln Gln Asn Cys Thr 
                165                 170                 175     


Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys Ala Lys Ile Asp Leu Val 
            180                 185                 190         


Asn Met His Ser Arg Val Asp Gln Leu Asp Phe Trp Glu Ser Gly Glu 
        195                 200                 205             


Trp Val Ile Val Asp Ala Val Gly Thr Tyr Asn Thr Arg Lys Tyr Glu 
    210                 215                 220                 


Cys Cys Ala Glu Ile Tyr Pro Asp Ile Thr Tyr Ala Phe Val Ile Arg 
225                 230                 235                 240 


Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Leu 
                245                 250                 255     


Ile Ser Cys Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Glu Cys Gly 
            260                 265                 270         


Glu Lys Ile Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe 
        275                 280                 285             


Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser Thr Ser Leu Val Ile Pro 
    290                 295                 300                 


Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser 
305                 310                 315                 320 


Ile Val Ile Thr Val Phe Val Leu Asn Val His His Arg Ser Pro Arg 
                325                 330                 335     


Thr His Thr Met Pro Thr Trp Val Arg Arg Val Phe Leu Asp Ile Val 
            340                 345                 350         


Pro Arg Leu Leu Leu Met Lys Arg Pro Ser Val Val Lys Asp Asn Cys 
        355                 360                 365             


Arg Arg Leu Ile Glu Ser Met His Lys Met Ala Ser Ala Pro Arg Phe 
    370                 375                 380                 


Trp Pro Glu Pro Glu Gly Glu Pro Pro Ala Thr Ser Gly Thr Gln Ser 
385                 390                 395                 400 


Leu His Pro Pro Ser Pro Ser Phe Cys Val Pro Leu Asp Val Pro Ala 
                405                 410                 415     


Glu Pro Gly Pro Ser Cys Lys Ser Pro Ser Asp Gln Leu Pro Pro Gln 
            420                 425                 430         


Gln Pro Leu Glu Ala Glu Lys Ala Ser Pro His Pro Ser Pro Gly Pro 
        435                 440                 445             


Cys Arg Pro Pro His Gly Thr Gln Ala Pro Gly Leu Ala Lys Ala Arg 
    450                 455                 460                 


Ser Leu Ser Val Gln His Met Ser Ser Pro Gly Glu Ala Val Glu Gly 
465                 470                 475                 480 


Gly Val Arg Cys Arg Ser Arg Ser Ile Gln Tyr Cys Val Pro Arg Asp 
                485                 490                 495     


Asp Ala Ala Pro Glu Ala Asp Gly Gln Ala Ala Gly Ala Leu Ala Ser 
            500                 505                 510         


Arg Asn Thr His Ser Ala Glu Leu Pro Pro Pro Asp Gln Pro Ser Pro 
        515                 520                 525             


Cys Lys Cys Thr Cys Lys Lys Glu Pro Ser Ser Val Ser Pro Ser Ala 
    530                 535                 540                 


Thr Val Lys Thr Arg Ser Thr Lys Ala Pro Pro Pro His Leu Pro Leu 
545                 550                 555                 560 


Ser Pro Ala Leu Thr Arg Ala Val Glu Gly Val Gln Tyr Ile Ala Asp 
                565                 570                 575     


His Leu Lys Ala Glu Asp Thr Asp Phe Ser Val Lys Glu Asp Trp Lys 
            580                 585                 590         


Tyr Val Ala Met Val Ile Asp Arg Ile Phe Leu Trp Met Phe Ile Ile 
        595                 600                 605             


Val Cys Leu Leu Gly Thr Val Gly Leu Phe Leu Pro Pro Trp Leu Ala 
    610                 615                 620                 


Gly Met Ile 
625         


<210>  2164
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA5__Homo_sapiens__NP_000736

<400>  2164

Met Ala Ala Arg Gly Ser Gly Pro Arg Ala Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Val Gln Leu Val Ala Gly Arg Cys Gly Leu Ala Gly Ala Ala Gly Gly 
            20                  25                  30          


Ala Gln Arg Gly Leu Ser Glu Pro Ser Ser Ile Ala Lys His Glu Asp 
        35                  40                  45              


Ser Leu Leu Lys Asp Leu Phe Gln Asp Tyr Glu Arg Trp Val Arg Pro 
    50                  55                  60                  


Val Glu His Leu Asn Asp Lys Ile Lys Ile Lys Phe Gly Leu Ala Ile 
65                  70                  75                  80  


Ser Gln Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Thr Thr Asn 
                85                  90                  95      


Val Trp Leu Lys Gln Glu Trp Ile Asp Val Lys Leu Arg Trp Asn Pro 
            100                 105                 110         


Asp Asp Tyr Gly Gly Ile Lys Val Ile Arg Val Pro Ser Asp Ser Val 
        115                 120                 125             


Trp Thr Pro Asp Ile Val Leu Phe Asp Asn Ala Asp Gly Arg Phe Glu 
    130                 135                 140                 


Gly Thr Ser Thr Lys Thr Val Ile Arg Tyr Asn Gly Thr Val Thr Trp 
145                 150                 155                 160 


Thr Pro Pro Ala Asn Tyr Lys Ser Ser Cys Thr Ile Asp Val Thr Phe 
                165                 170                 175     


Phe Pro Phe Asp Leu Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Thr 
            180                 185                 190         


Tyr Asp Gly Ser Gln Val Asp Ile Ile Leu Glu Asp Gln Asp Val Asp 
        195                 200                 205             


Lys Arg Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Val Ser Ala Thr 
    210                 215                 220                 


Gly Ser Lys Gly Asn Arg Thr Asp Ser Cys Cys Trp Tyr Pro Tyr Val 
225                 230                 235                 240 


Thr Tyr Ser Phe Val Ile Lys Arg Leu Pro Leu Phe Tyr Thr Leu Phe 
                245                 250                 255     


Leu Ile Ile Pro Cys Ile Gly Leu Ser Phe Leu Thr Val Leu Val Phe 
            260                 265                 270         


Tyr Leu Pro Ser Asn Glu Gly Glu Lys Ile Cys Leu Cys Thr Ser Val 
        275                 280                 285             


Leu Val Ser Leu Thr Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro 
    290                 295                 300                 


Ser Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Val Phe Thr 
305                 310                 315                 320 


Met Ile Phe Val Thr Leu Ser Ile Met Val Thr Val Phe Ala Ile Asn 
                325                 330                 335     


Ile His His Arg Ser Ser Ser Thr His Asn Ala Met Ala Pro Leu Val 
            340                 345                 350         


Arg Lys Ile Phe Leu His Thr Leu Pro Lys Leu Leu Cys Met Arg Ser 
        355                 360                 365             


His Val Asp Arg Tyr Phe Thr Gln Lys Glu Glu Thr Glu Ser Gly Ser 
    370                 375                 380                 


Gly Pro Lys Ser Ser Arg Asn Thr Leu Glu Ala Ala Leu Asp Ser Ile 
385                 390                 395                 400 


Arg Tyr Ile Thr Arg His Ile Met Lys Glu Asn Asp Val Arg Glu Val 
                405                 410                 415     


Val Glu Asp Trp Lys Phe Ile Ala Gln Val Leu Asp Arg Met Phe Leu 
            420                 425                 430         


Trp Thr Phe Leu Phe Val Ser Ile Val Gly Ser Leu Gly Leu Phe Val 
        435                 440                 445             


Pro Val Ile Tyr Lys Trp Ala Asn Ile Leu Ile Pro Val His Ile Gly 
    450                 455                 460                 


Asn Ala Asn Lys 
465             


<210>  2165
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA6__Homo_sapiens__NP_001186208

<400>  2165

Met Leu Thr Ser Lys Gly Gln Gly Phe Leu His Gly Gly Leu Cys Leu 
1               5                   10                  15      


Trp Leu Cys Val Phe Thr Pro Phe Phe Lys Gly Cys Val Gly Cys Ala 
            20                  25                  30          


Thr Glu Glu Arg Leu Phe His Lys Leu Phe Ser His Tyr Asn Gln Phe 
        35                  40                  45              


Ile Arg Pro Val Glu Asn Val Ser Asp Pro Val Thr Val His Phe Glu 
    50                  55                  60                  


Val Ala Ile Thr Gln Leu Ala Asn Val Ile Trp Asn Asp Tyr Lys Leu 
65                  70                  75                  80  


Arg Trp Asp Pro Met Glu Tyr Asp Gly Ile Glu Thr Leu Arg Val Pro 
                85                  90                  95      


Ala Asp Lys Ile Trp Lys Pro Asp Ile Val Leu Tyr Asn Asn Ala Val 
            100                 105                 110         


Gly Asp Phe Gln Val Glu Gly Lys Thr Lys Ala Leu Leu Lys Tyr Asn 
        115                 120                 125             


Gly Met Ile Thr Trp Thr Pro Pro Ala Ile Phe Lys Ser Ser Cys Pro 
    130                 135                 140                 


Met Asp Ile Thr Phe Phe Pro Phe Asp His Gln Asn Cys Ser Leu Lys 
145                 150                 155                 160 


Phe Gly Ser Trp Thr Tyr Asp Lys Ala Glu Ile Asp Leu Leu Ile Ile 
                165                 170                 175     


Gly Ser Lys Val Asp Met Asn Asp Phe Trp Glu Asn Ser Glu Trp Glu 
            180                 185                 190         


Ile Ile Asp Ala Ser Gly Tyr Lys His Asp Ile Lys Tyr Asn Cys Cys 
        195                 200                 205             


Glu Glu Ile Tyr Thr Asp Ile Thr Tyr Ser Phe Tyr Ile Arg Arg Leu 
    210                 215                 220                 


Pro Met Phe Tyr Thr Ile Asn Leu Ile Ile Pro Cys Leu Phe Ile Ser 
225                 230                 235                 240 


Phe Leu Thr Val Leu Val Phe Tyr Leu Pro Ser Asp Cys Gly Glu Lys 
                245                 250                 255     


Val Thr Leu Cys Ile Ser Val Leu Leu Ser Leu Thr Val Phe Leu Leu 
            260                 265                 270         


Val Ile Thr Glu Thr Ile Pro Ser Thr Ser Leu Val Val Pro Leu Val 
        275                 280                 285             


Gly Glu Tyr Leu Leu Phe Thr Met Ile Phe Val Thr Leu Ser Ile Val 
    290                 295                 300                 


Val Thr Val Phe Val Leu Asn Ile His Tyr Arg Thr Pro Thr Thr His 
305                 310                 315                 320 


Thr Met Pro Arg Trp Val Lys Thr Val Phe Leu Lys Leu Leu Pro Gln 
                325                 330                 335     


Val Leu Leu Met Arg Trp Pro Leu Asp Lys Thr Arg Gly Thr Gly Ser 
            340                 345                 350         


Asp Ala Val Pro Arg Gly Leu Ala Arg Arg Pro Ala Lys Gly Lys Leu 
        355                 360                 365             


Ala Ser His Gly Glu Pro Arg His Leu Lys Glu Cys Phe His Cys His 
    370                 375                 380                 


Lys Ser Asn Glu Leu Ala Thr Ser Lys Arg Arg Leu Ser His Gln Pro 
385                 390                 395                 400 


Leu Gln Trp Val Val Glu Asn Ser Glu His Ser Pro Glu Val Glu Asp 
                405                 410                 415     


Val Ile Asn Ser Val Gln Phe Ile Ala Glu Asn Met Lys Ser His Asn 
            420                 425                 430         


Glu Thr Lys Glu Val Glu Asp Asp Trp Lys Tyr Val Ala Met Val Val 
        435                 440                 445             


Asp Arg Val Phe Leu Trp Val Phe Ile Ile Val Cys Val Phe Gly Thr 
    450                 455                 460                 


Ala Gly Leu Phe Leu Gln Pro Leu Leu Gly Asn Thr Gly Lys Ser 
465                 470                 475                 


<210>  2166
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNA7__Homo_sapiens__NP_000737

<400>  2166

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Thr Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro 
225                 230                 235                 240 


Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala 
                245                 250                 255     


Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Thr Val Leu Leu Ser Leu 
            260                 265                 270         


Thr Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Thr Met Ile Ile Val 
    290                 295                 300                 


Gly Leu Ser Val Val Val Thr Val Ile Val Leu Gln Tyr His His His 
305                 310                 315                 320 


Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Thr Arg Val Ile Leu Leu 
                325                 330                 335     


Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys 
            340                 345                 350         


Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu Ala Ser 
        355                 360                 365             


Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly Asn Leu 
    370                 375                 380                 


Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys Val Pro Thr 
385                 390                 395                 400 


Pro Asp Ser Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro Thr His 
                405                 410                 415     


Asp Glu His Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp Pro Asp 
            420                 425                 430         


Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Phe Arg 
        435                 440                 445             


Cys Gln Asp Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe Ala Ala 
    450                 455                 460                 


Cys Val Val Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe Thr Ile 
465                 470                 475                 480 


Ile Cys Thr Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu Ala 
                485                 490                 495     


Val Ser Lys Asp Phe Ala 
            500         


<210>  2167
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNB1__Homo_sapiens__NP_000738

<400>  2167

Met Thr Pro Gly Ala Leu Leu Met Leu Leu Gly Ala Leu Gly Ala Pro 
1               5                   10                  15      


Leu Ala Pro Gly Val Arg Gly Ser Glu Ala Glu Gly Arg Leu Arg Glu 
            20                  25                  30          


Lys Leu Phe Ser Gly Tyr Asp Ser Ser Val Arg Pro Ala Arg Glu Val 
        35                  40                  45              


Gly Asp Arg Val Arg Val Ser Val Gly Leu Ile Leu Ala Gln Leu Ile 
    50                  55                  60                  


Ser Leu Asn Glu Lys Asp Glu Glu Met Ser Thr Lys Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Glu Trp Thr Asp Tyr Arg Leu Ser Trp Asp Pro Ala Glu His Asp 
                85                  90                  95      


Gly Ile Asp Ser Leu Arg Ile Thr Ala Glu Ser Val Trp Leu Pro Asp 
            100                 105                 110         


Val Val Leu Leu Asn Asn Asn Asp Gly Asn Phe Asp Val Ala Leu Asp 
        115                 120                 125             


Ile Ser Val Val Val Ser Ser Asp Gly Ser Val Arg Trp Gln Pro Pro 
    130                 135                 140                 


Gly Ile Tyr Arg Ser Ser Cys Ser Ile Gln Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Thr Met Val Phe Ser Ser Tyr Ser Tyr Asp Ser 
                165                 170                 175     


Ser Glu Val Ser Leu Gln Thr Gly Leu Gly Pro Asp Gly Gln Gly His 
            180                 185                 190         


Gln Glu Ile His Ile His Glu Gly Thr Phe Ile Glu Asn Gly Gln Trp 
        195                 200                 205             


Glu Ile Ile His Lys Pro Ser Arg Leu Ile Gln Pro Pro Gly Asp Pro 
    210                 215                 220                 


Arg Gly Gly Arg Glu Gly Gln Arg Gln Glu Val Ile Phe Tyr Leu Ile 
225                 230                 235                 240 


Ile Arg Arg Lys Pro Leu Phe Tyr Leu Val Asn Val Ile Ala Pro Cys 
                245                 250                 255     


Ile Leu Ile Thr Leu Leu Ala Ile Phe Val Phe Tyr Leu Pro Pro Asp 
            260                 265                 270         


Ala Gly Glu Lys Met Gly Leu Ser Ile Phe Ala Leu Leu Thr Leu Thr 
        275                 280                 285             


Val Phe Leu Leu Leu Leu Ala Asp Lys Val Pro Glu Thr Ser Leu Ser 
    290                 295                 300                 


Val Pro Ile Ile Ile Lys Tyr Leu Met Phe Thr Met Val Leu Val Thr 
305                 310                 315                 320 


Phe Ser Val Ile Leu Ser Val Val Val Leu Asn Leu His His Arg Ser 
                325                 330                 335     


Pro His Thr His Gln Met Pro Leu Trp Val Arg Gln Ile Phe Ile His 
            340                 345                 350         


Lys Leu Pro Leu Tyr Leu Arg Leu Lys Arg Pro Lys Pro Glu Arg Asp 
        355                 360                 365             


Leu Met Pro Glu Pro Pro His Cys Ser Ser Pro Gly Ser Gly Trp Gly 
    370                 375                 380                 


Arg Gly Thr Asp Glu Tyr Phe Ile Arg Lys Pro Pro Ser Asp Phe Leu 
385                 390                 395                 400 


Phe Pro Lys Pro Asn Arg Phe Gln Pro Glu Leu Ser Ala Pro Asp Leu 
                405                 410                 415     


Arg Arg Phe Ile Asp Gly Pro Asn Arg Ala Val Ala Leu Leu Pro Glu 
            420                 425                 430         


Leu Arg Glu Val Val Ser Ser Ile Ser Tyr Ile Ala Arg Gln Leu Gln 
        435                 440                 445             


Glu Gln Glu Asp His Asp Ala Leu Lys Glu Asp Trp Gln Phe Val Ala 
    450                 455                 460                 


Met Val Val Asp Arg Leu Phe Leu Trp Thr Phe Ile Ile Phe Thr Ser 
465                 470                 475                 480 


Val Gly Thr Leu Val Ile Phe Leu Asp Ala Thr Tyr His Leu Pro Pro 
                485                 490                 495     


Pro Asp Pro Phe Pro 
            500     


<210>  2168
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNB2__Homo_sapiens__NP_000739

<400>  2168

Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Thr Asp Thr Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Thr Asn Gly Ser Glu Leu Val Thr Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Thr Thr Asn 
65                  70                  75                  80  


Val Trp Leu Thr Gln Glu Trp Glu Asp Tyr Arg Leu Thr Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Thr Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Thr Tyr Asp Arg Thr Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Thr Tyr Val Asp Ile 
    210                 215                 220                 


Thr Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Thr Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Thr Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Thr Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Thr 
    290                 295                 300                 


Met Val Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Thr Thr His Thr Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Thr Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Thr Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Thr Thr Thr Thr Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys 
            500         


<210>  2169
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNB3__Homo_sapiens__NP_000740

<400>  2169

Met Leu Pro Asp Phe Met Leu Val Leu Ile Val Leu Gly Ile Pro Ser 
1               5                   10                  15      


Ser Ala Thr Thr Gly Phe Asn Ser Ile Ala Glu Asn Glu Asp Ala Leu 
            20                  25                  30          


Leu Arg His Leu Phe Gln Gly Tyr Gln Lys Trp Val Arg Pro Val Leu 
        35                  40                  45              


His Ser Asn Asp Thr Ile Lys Val Tyr Phe Gly Leu Lys Ile Ser Gln 
    50                  55                  60                  


Leu Val Asp Val Asp Glu Lys Asn Gln Leu Met Thr Thr Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Thr Asp His Lys Leu Arg Trp Asn Pro Asp Asp 
                85                  90                  95      


Tyr Gly Gly Ile His Ser Ile Lys Val Pro Ser Glu Ser Leu Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Phe Glu Asn Ala Asp Gly Arg Phe Glu Gly Ser 
        115                 120                 125             


Leu Met Thr Lys Val Ile Val Lys Ser Asn Gly Thr Val Val Trp Thr 
    130                 135                 140                 


Pro Pro Ala Ser Tyr Lys Ser Ser Cys Thr Met Asp Val Thr Phe Phe 
145                 150                 155                 160 


Pro Phe Asp Arg Gln Asn Cys Ser Met Lys Phe Gly Ser Trp Thr Tyr 
                165                 170                 175     


Asp Gly Thr Met Val Asp Leu Ile Leu Ile Asn Glu Asn Val Asp Arg 
            180                 185                 190         


Lys Asp Phe Phe Asp Asn Gly Glu Trp Glu Ile Leu Asn Ala Lys Gly 
        195                 200                 205             


Met Lys Gly Asn Arg Arg Asp Gly Val Tyr Ser Tyr Pro Phe Ile Thr 
    210                 215                 220                 


Tyr Ser Phe Val Leu Arg Arg Leu Pro Leu Phe Tyr Thr Leu Phe Leu 
225                 230                 235                 240 


Ile Ile Pro Cys Leu Gly Leu Ser Phe Leu Thr Val Leu Val Phe Tyr 
                245                 250                 255     


Leu Pro Ser Asp Glu Gly Glu Lys Leu Ser Leu Ser Thr Ser Val Leu 
            260                 265                 270         


Val Ser Leu Thr Val Phe Leu Leu Val Ile Glu Glu Ile Ile Pro Ser 
        275                 280                 285             


Ser Ser Lys Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Ile Met 
    290                 295                 300                 


Ile Phe Val Thr Leu Ser Ile Ile Val Thr Val Phe Val Ile Asn Val 
305                 310                 315                 320 


His His Arg Ser Ser Ser Thr Tyr His Pro Met Ala Pro Trp Val Lys 
                325                 330                 335     


Arg Leu Phe Leu Gln Lys Leu Pro Lys Leu Leu Cys Met Lys Asp His 
            340                 345                 350         


Val Asp Arg Tyr Ser Ser Pro Glu Lys Glu Glu Ser Gln Pro Val Val 
        355                 360                 365             


Lys Gly Lys Val Leu Glu Lys Lys Lys Gln Lys Gln Leu Ser Asp Gly 
    370                 375                 380                 


Glu Lys Val Leu Val Ala Phe Leu Glu Lys Ala Ala Asp Ser Ile Arg 
385                 390                 395                 400 


Tyr Ile Ser Arg His Val Lys Lys Glu His Phe Ile Ser Gln Val Val 
                405                 410                 415     


Gln Asp Trp Lys Phe Val Ala Gln Val Leu Asp Arg Ile Phe Leu Trp 
            420                 425                 430         


Leu Phe Leu Ile Val Ser Val Thr Gly Ser Val Leu Ile Phe Thr Pro 
        435                 440                 445             


Ala Leu Lys Met Trp Leu His Ser Tyr His 
    450                 455             


<210>  2170
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNB4__Homo_sapiens__NP_000741

<400>  2170

Met Arg Arg Ala Pro Ser Leu Val Leu Phe Phe Leu Val Ala Leu Cys 
1               5                   10                  15      


Gly Arg Gly Asn Cys Arg Val Ala Asn Ala Glu Glu Lys Leu Met Asp 
            20                  25                  30          


Asp Leu Leu Asn Lys Thr Arg Tyr Asn Asn Leu Ile Arg Pro Ala Thr 
        35                  40                  45              


Ser Ser Ser Gln Leu Ile Ser Ile Lys Leu Gln Leu Ser Leu Ala Gln 
    50                  55                  60                  


Leu Ile Ser Val Asn Glu Arg Glu Gln Ile Met Thr Thr Asn Val Trp 
65                  70                  75                  80  


Leu Lys Gln Glu Trp Thr Asp Tyr Arg Leu Thr Trp Asn Ser Ser Arg 
                85                  90                  95      


Tyr Glu Gly Val Asn Ile Leu Arg Ile Pro Ala Lys Arg Ile Trp Leu 
            100                 105                 110         


Pro Asp Ile Val Leu Tyr Asn Asn Ala Asp Gly Thr Tyr Glu Val Ser 
        115                 120                 125             


Val Tyr Thr Asn Leu Ile Val Arg Ser Asn Gly Ser Val Leu Trp Leu 
    130                 135                 140                 


Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys Tyr Phe 
145                 150                 155                 160 


Pro Phe Asp Gln Gln Asn Cys Thr Leu Lys Phe Arg Ser Trp Thr Tyr 
                165                 170                 175     


Asp His Thr Glu Ile Asp Met Val Leu Met Thr Pro Thr Ala Ser Met 
            180                 185                 190         


Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu Pro Gly 
        195                 200                 205             


Arg Arg Thr Val Asn Pro Gln Asp Pro Ser Tyr Val Asp Val Thr Tyr 
    210                 215                 220                 


Asp Phe Ile Ile Lys Arg Lys Pro Leu Phe Tyr Thr Ile Asn Leu Ile 
225                 230                 235                 240 


Ile Pro Cys Val Leu Thr Thr Leu Leu Ala Ile Leu Val Phe Tyr Leu 
                245                 250                 255     


Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val Leu Leu 
            260                 265                 270         


Ala Leu Thr Phe Phe Leu Leu Leu Ile Ser Lys Ile Val Pro Pro Thr 
        275                 280                 285             


Ser Leu Asp Val Pro Leu Ile Gly Lys Tyr Leu Met Phe Thr Met Val 
    290                 295                 300                 


Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn Val His 
305                 310                 315                 320 


His Arg Ser Pro Ser Thr His Thr Met Ala Pro Trp Val Lys Arg Cys 
                325                 330                 335     


Phe Leu His Lys Leu Pro Thr Phe Leu Phe Met Lys Arg Pro Gly Pro 
            340                 345                 350         


Asp Ser Ser Pro Ala Arg Ala Phe Pro Pro Ser Lys Ser Cys Val Thr 
        355                 360                 365             


Lys Pro Glu Ala Thr Ala Thr Ser Thr Ser Pro Ser Asn Phe Tyr Gly 
    370                 375                 380                 


Asn Ser Met Tyr Phe Val Asn Pro Ala Ser Ala Ala Ser Lys Ser Pro 
385                 390                 395                 400 


Ala Gly Ser Thr Pro Val Ala Ile Pro Arg Asp Phe Trp Leu Arg Ser 
                405                 410                 415     


Ser Gly Arg Phe Arg Gln Asp Val Gln Glu Ala Leu Glu Gly Val Ser 
            420                 425                 430         


Phe Ile Ala Gln His Met Lys Asn Asp Asp Glu Asp Gln Ser Val Val 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Val Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Val Phe Met Phe Val Cys Val Leu Gly Thr Val Gly Leu Phe Leu Pro 
465                 470                 475                 480 


Pro Leu Phe Gln Thr His Ala Ala Ser Glu Gly Pro Tyr Ala Ala Gln 
                485                 490                 495     


Arg Asp 
        


<210>  2171
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRND__Homo_sapiens__NP_000742

<400>  2171

Met Glu Gly Pro Val Leu Thr Leu Gly Leu Leu Ala Ala Leu Ala Val 
1               5                   10                  15      


Cys Gly Ser Trp Gly Leu Asn Glu Glu Glu Arg Leu Ile Arg His Leu 
            20                  25                  30          


Phe Gln Glu Lys Gly Tyr Asn Lys Glu Leu Arg Pro Val Ala His Lys 
        35                  40                  45              


Glu Glu Ser Val Asp Val Ala Leu Ala Leu Thr Leu Ser Asn Leu Ile 
    50                  55                  60                  


Ser Leu Lys Glu Val Glu Glu Thr Leu Thr Thr Asn Val Trp Ile Glu 
65                  70                  75                  80  


His Gly Trp Thr Asp Asn Arg Leu Lys Trp Asn Ala Glu Glu Phe Gly 
                85                  90                  95      


Asn Ile Ser Val Leu Arg Leu Pro Pro Asp Met Val Trp Leu Pro Glu 
            100                 105                 110         


Ile Val Leu Glu Asn Asn Asn Asp Gly Ser Phe Gln Ile Ser Tyr Ser 
        115                 120                 125             


Cys Asn Val Leu Val Tyr His Tyr Gly Phe Val Tyr Trp Leu Pro Pro 
    130                 135                 140                 


Ala Ile Phe Arg Ser Ser Cys Pro Ile Ser Val Thr Tyr Phe Pro Phe 
145                 150                 155                 160 


Asp Trp Gln Asn Cys Ser Leu Lys Phe Ser Ser Leu Lys Tyr Thr Ala 
                165                 170                 175     


Lys Glu Ile Thr Leu Ser Leu Lys Gln Asp Ala Lys Glu Asn Arg Thr 
            180                 185                 190         


Tyr Pro Val Glu Trp Ile Ile Ile Asp Pro Glu Gly Phe Thr Glu Asn 
        195                 200                 205             


Gly Glu Trp Glu Ile Val His Arg Pro Ala Arg Val Asn Val Asp Pro 
    210                 215                 220                 


Arg Ala Pro Leu Asp Ser Pro Ser Arg Gln Asp Ile Thr Phe Tyr Leu 
225                 230                 235                 240 


Ile Ile Arg Arg Lys Pro Leu Phe Tyr Ile Ile Asn Ile Leu Val Pro 
                245                 250                 255     


Cys Val Leu Ile Ser Phe Met Val Asn Leu Val Phe Tyr Leu Pro Ala 
            260                 265                 270         


Asp Ser Gly Glu Lys Thr Ser Val Ala Ile Ser Val Leu Leu Ala Gln 
        275                 280                 285             


Ser Val Phe Leu Leu Leu Ile Ser Lys Arg Leu Pro Ala Thr Ser Met 
    290                 295                 300                 


Ala Ile Pro Leu Ile Gly Lys Phe Leu Leu Phe Gly Met Val Leu Val 
305                 310                 315                 320 


Thr Met Val Val Val Ile Cys Val Ile Val Leu Asn Ile His Phe Arg 
                325                 330                 335     


Thr Pro Ser Thr His Val Leu Ser Glu Gly Val Lys Lys Leu Phe Leu 
            340                 345                 350         


Glu Thr Leu Pro Glu Leu Leu His Met Ser Arg Pro Ala Glu Asp Gly 
        355                 360                 365             


Pro Ser Pro Gly Ala Leu Val Arg Arg Ser Ser Ser Leu Gly Tyr Ile 
    370                 375                 380                 


Ser Lys Ala Glu Glu Tyr Phe Leu Leu Lys Ser Arg Ser Asp Leu Met 
385                 390                 395                 400 


Phe Glu Lys Gln Ser Glu Arg His Gly Leu Ala Arg Arg Leu Thr Thr 
                405                 410                 415     


Ala Arg Arg Pro Pro Ala Ser Ser Glu Gln Ala Gln Gln Glu Leu Phe 
            420                 425                 430         


Asn Glu Leu Lys Pro Ala Val Asp Gly Ala Asn Phe Ile Val Asn His 
        435                 440                 445             


Met Arg Asp Gln Asn Asn Tyr Asn Glu Glu Lys Asp Ser Trp Asn Arg 
    450                 455                 460                 


Val Ala Arg Thr Val Asp Arg Leu Cys Leu Phe Val Val Thr Pro Val 
465                 470                 475                 480 


Met Val Val Gly Thr Ala Trp Ile Phe Leu Gln Gly Val Tyr Asn Gln 
                485                 490                 495     


Pro Pro Pro Gln Pro Phe Pro Gly Asp Pro Tyr Ser Tyr Asn Val Gln 
            500                 505                 510         


Asp Lys Arg Phe Ile 
        515         


<210>  2172
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNE__Homo_sapiens__NP_000071

<400>  2172

Met Ala Arg Ala Pro Leu Gly Val Leu Leu Leu Leu Gly Leu Leu Gly 
1               5                   10                  15      


Arg Gly Val Gly Lys Asn Glu Glu Leu Arg Leu Tyr His His Leu Phe 
            20                  25                  30          


Asn Asn Tyr Asp Pro Gly Ser Arg Pro Val Arg Glu Pro Glu Asp Thr 
        35                  40                  45              


Val Thr Ile Ser Leu Lys Val Thr Leu Thr Asn Leu Ile Ser Leu Asn 
    50                  55                  60                  


Glu Lys Glu Glu Thr Leu Thr Thr Ser Val Trp Ile Gly Ile Asp Trp 
65                  70                  75                  80  


Gln Asp Tyr Arg Leu Asn Tyr Ser Lys Asp Asp Phe Gly Gly Ile Glu 
                85                  90                  95      


Thr Leu Arg Val Pro Ser Glu Leu Val Trp Leu Pro Glu Ile Val Leu 
            100                 105                 110         


Glu Asn Asn Ile Asp Gly Gln Phe Gly Val Ala Tyr Asp Ala Asn Val 
        115                 120                 125             


Leu Val Tyr Glu Gly Gly Ser Val Thr Trp Leu Pro Pro Ala Ile Tyr 
    130                 135                 140                 


Arg Ser Val Cys Ala Val Glu Val Thr Tyr Phe Pro Phe Asp Trp Gln 
145                 150                 155                 160 


Asn Cys Ser Leu Ile Phe Arg Ser Gln Thr Tyr Asn Ala Glu Glu Val 
                165                 170                 175     


Glu Phe Thr Phe Ala Val Asp Asn Asp Gly Lys Thr Ile Asn Lys Ile 
            180                 185                 190         


Asp Ile Asp Thr Glu Ala Tyr Thr Glu Asn Gly Glu Trp Ala Ile Asp 
        195                 200                 205             


Phe Cys Pro Gly Val Ile Arg Arg His His Gly Gly Ala Thr Asp Gly 
    210                 215                 220                 


Pro Gly Glu Thr Asp Val Ile Tyr Ser Leu Ile Ile Arg Arg Lys Pro 
225                 230                 235                 240 


Leu Phe Tyr Val Ile Asn Ile Ile Val Pro Cys Val Leu Ile Ser Gly 
                245                 250                 255     


Leu Val Leu Leu Ala Tyr Phe Leu Pro Ala Gln Ala Gly Gly Gln Lys 
            260                 265                 270         


Cys Thr Val Ser Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu Phe 
        275                 280                 285             


Leu Ile Ala Gln Lys Ile Pro Glu Thr Ser Leu Ser Val Pro Leu Leu 
    290                 295                 300                 


Gly Arg Phe Leu Ile Phe Val Met Val Val Ala Thr Leu Ile Val Met 
305                 310                 315                 320 


Asn Cys Val Ile Val Leu Asn Val Ser Gln Arg Thr Pro Thr Thr His 
                325                 330                 335     


Ala Met Ser Pro Arg Leu Arg His Val Leu Leu Glu Leu Leu Pro Arg 
            340                 345                 350         


Leu Leu Gly Ser Pro Pro Pro Pro Glu Ala Pro Arg Ala Ala Ser Pro 
        355                 360                 365             


Pro Arg Arg Ala Ser Ser Val Gly Leu Leu Leu Arg Ala Glu Glu Leu 
    370                 375                 380                 


Ile Leu Lys Lys Pro Arg Ser Glu Leu Val Phe Glu Gly Gln Arg His 
385                 390                 395                 400 


Arg Gln Gly Thr Trp Thr Ala Ala Phe Cys Gln Ser Leu Gly Ala Ala 
                405                 410                 415     


Ala Pro Glu Val Arg Cys Cys Val Asp Ala Val Asn Phe Val Ala Glu 
            420                 425                 430         


Ser Thr Arg Asp Gln Glu Ala Thr Gly Glu Glu Val Ser Asp Trp Val 
        435                 440                 445             


Arg Met Gly Asn Ala Leu Asp Asn Ile Cys Phe Trp Ala Ala Leu Val 
    450                 455                 460                 


Leu Phe Ser Val Gly Ser Ser Leu Ile Phe Leu Gly Ala Tyr Phe Asn 
465                 470                 475                 480 


Arg Val Pro Asp Leu Pro Tyr Ala Pro Cys Ile Gln Pro 
                485                 490             


<210>  2173
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHRNG__Homo_sapiens__NP_005190

<400>  2173

Met His Gly Gly Gln Gly Pro Leu Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Cys Leu Gly Ala Gln Gly Arg Asn Gln Glu Glu Arg Leu Leu Ala Asp 
            20                  25                  30          


Leu Met Gln Asn Tyr Asp Pro Asn Leu Arg Pro Ala Glu Arg Asp Ser 
        35                  40                  45              


Asp Val Val Asn Val Ser Leu Lys Leu Thr Leu Thr Asn Leu Ile Ser 
    50                  55                  60                  


Leu Asn Glu Arg Glu Glu Ala Leu Thr Thr Asn Val Trp Ile Glu Met 
65                  70                  75                  80  


Gln Trp Cys Asp Tyr Arg Leu Arg Trp Asp Pro Arg Asp Tyr Glu Gly 
                85                  90                  95      


Leu Trp Val Leu Arg Val Pro Ser Thr Met Val Trp Arg Pro Asp Ile 
            100                 105                 110         


Val Leu Glu Asn Asn Val Asp Gly Val Phe Glu Val Ala Leu Tyr Cys 
        115                 120                 125             


Asn Val Leu Val Ser Pro Asp Gly Cys Ile Tyr Trp Leu Pro Pro Ala 
    130                 135                 140                 


Ile Phe Arg Ser Ala Cys Ser Ile Ser Val Thr Tyr Phe Pro Phe Asp 
145                 150                 155                 160 


Trp Gln Asn Cys Ser Leu Ile Phe Gln Ser Gln Thr Tyr Ser Thr Asn 
                165                 170                 175     


Glu Ile Asp Leu Gln Leu Ser Gln Glu Asp Gly Gln Thr Ile Glu Trp 
            180                 185                 190         


Ile Phe Ile Asp Pro Glu Ala Phe Thr Glu Asn Gly Glu Trp Ala Ile 
        195                 200                 205             


Gln His Arg Pro Ala Lys Met Leu Leu Asp Pro Ala Ala Pro Ala Gln 
    210                 215                 220                 


Glu Ala Gly His Gln Lys Val Val Phe Tyr Leu Leu Ile Gln Arg Lys 
225                 230                 235                 240 


Pro Leu Phe Tyr Val Ile Asn Ile Ile Ala Pro Cys Val Leu Ile Ser 
                245                 250                 255     


Ser Val Ala Ile Leu Ile His Phe Leu Pro Ala Lys Ala Gly Gly Gln 
            260                 265                 270         


Lys Cys Thr Val Ala Ile Asn Val Leu Leu Ala Gln Thr Val Phe Leu 
        275                 280                 285             


Phe Leu Val Ala Lys Lys Val Pro Glu Thr Ser Gln Ala Val Pro Leu 
    290                 295                 300                 


Ile Ser Lys Tyr Leu Thr Phe Leu Leu Val Val Thr Ile Leu Ile Val 
305                 310                 315                 320 


Val Asn Ala Val Val Val Leu Asn Val Ser Leu Arg Ser Pro His Thr 
                325                 330                 335     


His Ser Met Ala Arg Gly Val Arg Lys Val Phe Leu Arg Leu Leu Pro 
            340                 345                 350         


Gln Leu Leu Arg Met His Val Arg Pro Leu Ala Pro Ala Ala Val Gln 
        355                 360                 365             


Asp Thr Gln Ser Arg Leu Gln Asn Gly Ser Ser Gly Trp Ser Ile Thr 
    370                 375                 380                 


Thr Gly Glu Glu Val Ala Leu Cys Leu Pro Arg Ser Glu Leu Leu Phe 
385                 390                 395                 400 


Gln Gln Trp Gln Arg Gln Gly Leu Val Ala Ala Ala Leu Glu Lys Leu 
                405                 410                 415     


Glu Lys Gly Pro Glu Leu Gly Leu Ser Gln Phe Cys Gly Ser Leu Lys 
            420                 425                 430         


Gln Ala Ala Pro Ala Ile Gln Ala Cys Val Glu Ala Cys Asn Leu Ile 
        435                 440                 445             


Ala Cys Ala Arg His Gln Gln Ser His Phe Asp Asn Gly Asn Glu Glu 
    450                 455                 460                 


Trp Phe Leu Val Gly Arg Val Leu Asp Arg Val Cys Phe Leu Ala Met 
465                 470                 475                 480 


Leu Ser Leu Phe Ile Cys Gly Thr Ala Gly Ile Phe Leu Met Ala His 
                485                 490                 495     


Tyr Asn Arg Val Pro Ala Leu Pro Phe Pro Gly Asp Pro Arg Pro Tyr 
            500                 505                 510         


Leu Pro Ser Pro Asp 
        515         


<210>  2174
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST10__Homo_sapiens__NP_004845

<400>  2174

Met His His Gln Trp Leu Leu Leu Ala Ala Cys Phe Trp Val Ile Phe 
1               5                   10                  15      


Met Phe Met Val Ala Ser Lys Phe Ile Thr Leu Thr Phe Lys Asp Pro 
            20                  25                  30          


Asp Val Tyr Ser Ala Lys Gln Glu Phe Leu Phe Leu Thr Thr Met Pro 
        35                  40                  45              


Glu Val Arg Lys Leu Pro Glu Glu Lys His Ile Pro Glu Glu Leu Lys 
    50                  55                  60                  


Pro Thr Gly Lys Glu Leu Pro Asp Ser Gln Leu Val Gln Pro Leu Val 
65                  70                  75                  80  


Tyr Met Glu Arg Leu Glu Leu Ile Arg Asn Val Cys Arg Asp Asp Ala 
                85                  90                  95      


Leu Lys Asn Leu Ser His Thr Pro Val Ser Lys Phe Val Leu Asp Arg 
            100                 105                 110         


Ile Phe Val Cys Asp Lys His Lys Ile Leu Phe Cys Gln Thr Pro Lys 
        115                 120                 125             


Val Gly Asn Thr Gln Trp Lys Lys Val Leu Ile Val Leu Asn Gly Ala 
    130                 135                 140                 


Phe Ser Ser Ile Glu Glu Ile Pro Glu Asn Val Val His Asp His Glu 
145                 150                 155                 160 


Lys Asn Gly Leu Pro Arg Leu Ser Ser Phe Ser Asp Ala Glu Ile Gln 
                165                 170                 175     


Lys Arg Leu Lys Thr Tyr Phe Lys Phe Phe Ile Val Arg Asp Pro Phe 
            180                 185                 190         


Glu Arg Leu Ile Ser Ala Phe Lys Asp Lys Phe Val His Asn Pro Arg 
        195                 200                 205             


Phe Glu Pro Trp Tyr Arg His Glu Ile Ala Pro Gly Ile Ile Arg Lys 
    210                 215                 220                 


Tyr Arg Arg Asn Arg Thr Glu Thr Arg Gly Ile Gln Phe Glu Asp Phe 
225                 230                 235                 240 


Val Arg Tyr Leu Gly Asp Pro Asn His Arg Trp Leu Asp Leu Gln Phe 
                245                 250                 255     


Gly Asp His Ile Ile His Trp Val Thr Tyr Val Glu Leu Cys Ala Pro 
            260                 265                 270         


Cys Glu Ile Met Tyr Ser Val Ile Gly His His Glu Thr Leu Glu Asp 
        275                 280                 285             


Asp Ala Pro Tyr Ile Leu Lys Glu Ala Gly Ile Asp His Leu Val Ser 
    290                 295                 300                 


Tyr Pro Thr Ile Pro Pro Gly Ile Thr Val Tyr Asn Arg Thr Lys Val 
305                 310                 315                 320 


Glu His Tyr Phe Leu Gly Ile Ser Lys Arg Asp Ile Arg Arg Leu Tyr 
                325                 330                 335     


Ala Arg Phe Glu Gly Asp Phe Lys Leu Phe Gly Tyr Gln Lys Pro Asp 
            340                 345                 350         


Phe Leu Leu Asn 
        355     


<210>  2175
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST11__Homo_sapiens__NP_001167453

<400>  2175

Met Lys Pro Ala Leu Leu Glu Val Met Arg Met Asn Arg Ile Cys Arg 
1               5                   10                  15      


Met Val Leu Ala Thr Cys Leu Gly Ser Phe Ile Leu Val Ile Phe Tyr 
            20                  25                  30          


Phe Gln Ile Met Arg Arg Asn Pro Phe Gly Val Asp Ile Cys Cys Arg 
        35                  40                  45              


Lys Gly Ser Arg Ser Pro Leu Gln Glu Leu Tyr Asn Pro Ile Gln Leu 
    50                  55                  60                  


Glu Leu Ser Asn Thr Ala Val Leu His Gln Met Arg Arg Asp Gln Val 
65                  70                  75                  80  


Thr Asp Thr Cys Arg Ala Asn Ser Ala Thr Ser Arg Lys Arg Arg Val 
                85                  90                  95      


Leu Thr Pro Asn Asp Leu Lys His Leu Val Val Asp Glu Asp His Glu 
            100                 105                 110         


Leu Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys Thr Asn Trp Lys Arg 
        115                 120                 125             


Leu Met Met Val Leu Thr Gly Arg Gly Lys Tyr Ser Asp Pro Met Glu 
    130                 135                 140                 


Ile Pro Ala Asn Glu Ala His Val Ser Ala Asn Leu Lys Thr Leu Asn 
145                 150                 155                 160 


Gln Tyr Ser Ile Pro Glu Ile Asn His Arg Leu Lys Ser Tyr Met Lys 
                165                 170                 175     


Phe Leu Phe Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Tyr Arg 
            180                 185                 190         


Asn Lys Phe Thr Gln Lys Tyr Asn Ile Ser Phe His Lys Arg Tyr Gly 
        195                 200                 205             


Thr Lys Ile Ile Lys Arg Gln Arg Lys Asn Ala Thr Gln Glu Ala Leu 
    210                 215                 220                 


Arg Lys Gly Asp Asp Val Lys Phe Glu Glu Phe Val Ala Tyr Leu Ile 
225                 230                 235                 240 


Asp Pro His Thr Gln Arg Glu Glu Pro Phe Asn Glu His Trp Gln Thr 
                245                 250                 255     


Val Tyr Ser Leu Cys His Pro Cys His Ile His Tyr Asp Leu Val Gly 
            260                 265                 270         


Lys Tyr Glu Thr Leu Glu Glu Asp Ser Asn Tyr Val Leu Gln Leu Ala 
        275                 280                 285             


Gly Val Gly Ser Tyr Leu Lys Phe Pro Thr Tyr Ala Lys Ser Thr Arg 
    290                 295                 300                 


Thr Thr Asp Glu Met Thr Thr Glu Phe Phe Gln Asn Ile Ser Ser Glu 
305                 310                 315                 320 


His Gln Thr Gln Leu Tyr Glu Val Tyr Lys Leu Asp Phe Leu Met Phe 
                325                 330                 335     


Asn Tyr Ser Val Pro Ser Tyr Leu Lys Leu Glu 
            340                 345         


<210>  2176
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST12__Homo_sapiens__NP_001230724

<400>  2176

Met Thr Lys Ala Arg Leu Phe Arg Leu Trp Leu Val Leu Gly Ser Val 
1               5                   10                  15      


Phe Met Ile Leu Leu Ile Ile Val Tyr Trp Asp Ser Ala Gly Ala Ala 
            20                  25                  30          


His Phe Tyr Leu His Thr Ser Phe Ser Arg Pro His Thr Gly Pro Pro 
        35                  40                  45              


Leu Pro Thr Pro Gly Pro Asp Arg Asp Arg Glu Leu Thr Ala Asp Ser 
    50                  55                  60                  


Asp Val Asp Glu Phe Leu Asp Lys Phe Leu Ser Ala Gly Val Lys Gln 
65                  70                  75                  80  


Ser Asp Leu Pro Arg Lys Glu Thr Glu Gln Pro Pro Ala Pro Gly Ser 
                85                  90                  95      


Met Glu Glu Ser Val Arg Gly Tyr Asp Trp Ser Pro Arg Asp Ala Arg 
            100                 105                 110         


Arg Ser Pro Asp Gln Gly Arg Gln Gln Ala Glu Arg Arg Ser Val Leu 
        115                 120                 125             


Arg Gly Phe Cys Ala Asn Ser Ser Leu Ala Phe Pro Thr Lys Glu Arg 
    130                 135                 140                 


Ala Phe Asp Asp Ile Pro Asn Ser Glu Leu Ser His Leu Ile Val Asp 
145                 150                 155                 160 


Asp Arg His Gly Ala Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys Thr 
                165                 170                 175     


Asn Trp Lys Arg Val Met Ile Val Leu Ser Gly Ser Leu Leu His Arg 
            180                 185                 190         


Gly Ala Pro Tyr Arg Asp Pro Leu Arg Ile Pro Arg Glu His Val His 
        195                 200                 205             


Asn Ala Ser Ala His Leu Thr Phe Asn Lys Phe Trp Arg Arg Tyr Gly 
    210                 215                 220                 


Lys Leu Ser Arg His Leu Met Lys Val Lys Leu Lys Lys Tyr Thr Lys 
225                 230                 235                 240 


Phe Leu Phe Val Arg Asp Pro Phe Val Arg Leu Ile Ser Ala Phe Arg 
                245                 250                 255     


Ser Lys Phe Glu Leu Glu Asn Glu Glu Phe Tyr Arg Lys Phe Ala Val 
            260                 265                 270         


Pro Met Leu Arg Leu Tyr Ala Asn His Thr Ser Leu Pro Ala Ser Ala 
        275                 280                 285             


Arg Glu Ala Phe Arg Ala Gly Leu Lys Val Ser Phe Ala Asn Phe Ile 
    290                 295                 300                 


Gln Tyr Leu Leu Asp Pro His Thr Glu Lys Leu Ala Pro Phe Asn Glu 
305                 310                 315                 320 


His Trp Arg Gln Val Tyr Arg Leu Cys His Pro Cys Gln Ile Asp Tyr 
                325                 330                 335     


Asp Phe Val Gly Lys Leu Glu Thr Leu Asp Glu Asp Ala Ala Gln Leu 
            340                 345                 350         


Leu Gln Leu Leu Gln Val Asp Arg Gln Leu Arg Phe Pro Pro Ser Tyr 
        355                 360                 365             


Arg Asn Arg Thr Ala Ser Ser Trp Glu Glu Asp Trp Phe Ala Lys Ile 
    370                 375                 380                 


Pro Leu Ala Trp Arg Gln Gln Leu Tyr Lys Leu Tyr Glu Ala Asp Phe 
385                 390                 395                 400 


Val Leu Phe Gly Tyr Pro Lys Pro Glu Asn Leu Leu Arg Asp 
                405                 410                 


<210>  2177
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST13__Homo_sapiens__NP_690849

<400>  2177

Met Gly Arg Arg Cys Cys Arg Arg Arg Val Leu Ala Ala Ala Cys Leu 
1               5                   10                  15      


Gly Ala Ala Leu Leu Leu Leu Cys Ala Ala Pro Arg Ser Leu Arg Pro 
            20                  25                  30          


Ala Phe Gly Asn Arg Ala Leu Gly Ser Ser Trp Leu Gly Gly Glu Lys 
        35                  40                  45              


Arg Ser Pro Leu Gln Lys Leu Tyr Asp Leu Asp Gln Asp Pro Arg Ser 
    50                  55                  60                  


Thr Leu Ala Lys Val His Arg Gln Arg Arg Asp Leu Leu Asn Ser Ala 
65                  70                  75                  80  


Cys Ser Arg His Ser Arg Arg Gln Arg Leu Leu Gln Pro Glu Asp Leu 
                85                  90                  95      


Arg His Val Leu Val Asp Asp Ala His Gly Leu Leu Tyr Cys Tyr Val 
            100                 105                 110         


Pro Lys Val Ala Cys Thr Asn Trp Lys Arg Val Leu Leu Ala Leu Ser 
        115                 120                 125             


Gly Gln Ala Arg Gly Asp Pro Arg Ala Ile Ser Ala Gln Glu Ala His 
    130                 135                 140                 


Ala Pro Gly Arg Leu Pro Ser Leu Ala Asp Phe Ser Pro Ala Glu Ile 
145                 150                 155                 160 


Asn Arg Arg Leu Arg Ala Tyr Leu Ala Phe Leu Phe Val Arg Glu Pro 
                165                 170                 175     


Phe Glu Arg Leu Ala Ser Ala Tyr Arg Asn Lys Leu Ala Arg Pro Tyr 
            180                 185                 190         


Ser Ala Ala Phe Gln Arg Arg Tyr Gly Ala Arg Ile Val Gln Arg Leu 
        195                 200                 205             


Arg Pro Arg Ala Leu Pro Asp Ala Arg Ala Arg Gly His Asp Val Arg 
    210                 215                 220                 


Phe Ala Glu Phe Leu Ala Tyr Leu Leu Asp Pro Arg Thr Arg Arg Glu 
225                 230                 235                 240 


Glu Pro Phe Asn Glu His Trp Glu Arg Ala His Ala Leu Cys His Pro 
                245                 250                 255     


Cys Arg Leu Arg Tyr Asp Val Val Gly Lys Phe Glu Thr Leu Ala Glu 
            260                 265                 270         


Asp Ala Ala Phe Val Leu Gly Leu Ala Gly Ala Ser Asp Leu Ser Phe 
        275                 280                 285             


Pro Gly Pro Pro Arg Pro Arg Gly Ala Ala Ala Ser Arg Asp Leu Ala 
    290                 295                 300                 


Ala Arg Leu Phe Arg Asp Ile Ser Pro Phe Tyr Gln Arg Arg Leu Phe 
305                 310                 315                 320 


Asp Leu Tyr Lys Met Asp Phe Leu Leu Phe Asn Tyr Ser Ala Pro Ser 
                325                 330                 335     


Tyr Leu Arg Leu Leu 
            340     


<210>  2178
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST14__Homo_sapiens__NP_569735

<400>  2178

Met Phe Pro Arg Pro Leu Thr Pro Leu Ala Ala Pro Asn Gly Ala Glu 
1               5                   10                  15      


Pro Leu Gly Arg Ala Leu Arg Arg Ala Pro Leu Gly Arg Ala Arg Ala 
            20                  25                  30          


Gly Leu Gly Gly Pro Pro Leu Leu Leu Pro Ser Met Leu Met Phe Ala 
        35                  40                  45              


Val Ile Val Ala Ser Ser Gly Leu Leu Leu Met Ile Glu Arg Gly Ile 
    50                  55                  60                  


Leu Ala Glu Met Lys Pro Leu Pro Leu His Pro Pro Gly Arg Glu Gly 
65                  70                  75                  80  


Thr Ala Trp Arg Gly Lys Ala Pro Lys Pro Gly Gly Leu Ser Leu Arg 
                85                  90                  95      


Ala Gly Asp Ala Asp Leu Gln Val Arg Gln Asp Val Arg Asn Arg Thr 
            100                 105                 110         


Leu Arg Ala Val Cys Gly Gln Pro Gly Met Pro Arg Asp Pro Trp Asp 
        115                 120                 125             


Leu Pro Val Gly Gln Arg Arg Thr Leu Leu Arg His Ile Leu Val Ser 
    130                 135                 140                 


Asp Arg Tyr Arg Phe Leu Tyr Cys Tyr Val Pro Lys Val Ala Cys Ser 
145                 150                 155                 160 


Asn Trp Lys Arg Val Met Lys Val Leu Ala Gly Val Leu Asp Ser Val 
                165                 170                 175     


Asp Val Arg Leu Lys Met Asp His Arg Ser Asp Leu Val Phe Leu Ala 
            180                 185                 190         


Asp Leu Arg Pro Glu Glu Ile Arg Tyr Arg Leu Gln His Tyr Phe Lys 
        195                 200                 205             


Phe Leu Phe Val Arg Glu Pro Leu Glu Arg Leu Leu Ser Ala Tyr Arg 
    210                 215                 220                 


Asn Lys Phe Gly Glu Ile Arg Glu Tyr Gln Gln Arg Tyr Gly Ala Glu 
225                 230                 235                 240 


Ile Val Arg Arg Tyr Arg Ala Gly Ala Gly Pro Ser Pro Ala Gly Asp 
                245                 250                 255     


Asp Val Thr Phe Pro Glu Phe Leu Arg Tyr Leu Val Asp Glu Asp Pro 
            260                 265                 270         


Glu Arg Met Asn Glu His Trp Met Pro Val Tyr His Leu Cys Gln Pro 
        275                 280                 285             


Cys Ala Val His Tyr Asp Phe Val Gly Ser Tyr Glu Arg Leu Glu Ala 
    290                 295                 300                 


Asp Ala Asn Gln Val Leu Glu Trp Val Arg Ala Pro Pro His Val Arg 
305                 310                 315                 320 


Phe Pro Ala Arg Gln Ala Trp Tyr Arg Pro Ala Ser Pro Glu Ser Leu 
                325                 330                 335     


His Tyr His Leu Cys Ser Ala Pro Arg Ala Leu Leu Gln Asp Val Leu 
            340                 345                 350         


Pro Lys Tyr Ile Leu Asp Phe Ser Leu Phe Ala Tyr Pro Leu Pro Asn 
        355                 360                 365             


Val Thr Lys Glu Ala Cys Gln Gln 
    370                 375     


<210>  2179
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST15__Homo_sapiens__NP_001257694

<400>  2179

Met Arg His Cys Ile Asn Cys Cys Ile Gln Leu Leu Pro Asp Gly Ala 
1               5                   10                  15      


His Lys Gln Gln Val Asn Cys Gln Gly Gly Pro His His Gly His Gln 
            20                  25                  30          


Ala Cys Pro Thr Cys Lys Gly Glu Asn Lys Ile Leu Phe Arg Val Asp 
        35                  40                  45              


Ser Lys Gln Met Asn Leu Leu Ala Val Leu Glu Val Arg Thr Glu Gly 
    50                  55                  60                  


Asn Glu Asn Trp Gly Gly Phe Leu Arg Phe Lys Lys Gly Lys Arg Cys 
65                  70                  75                  80  


Ser Leu Val Phe Gly Leu Ile Ile Met Thr Leu Val Met Ala Ser Tyr 
                85                  90                  95      


Ile Leu Ser Gly Ala His Gln Glu Leu Leu Ile Ser Ser Pro Phe His 
            100                 105                 110         


Tyr Gly Gly Phe Pro Ser Asn Pro Ser Leu Met Asp Ser Glu Asn Pro 
        115                 120                 125             


Ser Asp Thr Lys Glu His His His Gln Ser Ser Val Asn Asn Ile Ser 
    130                 135                 140                 


Tyr Met Lys Asp Tyr Pro Ser Ile Lys Leu Ile Ile Asn Ser Ile Thr 
145                 150                 155                 160 


Thr Arg Ile Glu Phe Thr Thr Arg Gln Leu Pro Asp Leu Glu Asp Leu 
                165                 170                 175     


Lys Lys Gln Glu Leu His Met Phe Ser Val Ile Pro Asn Lys Phe Leu 
            180                 185                 190         


Pro Asn Ser Lys Ser Pro Cys Trp Tyr Glu Glu Phe Ser Gly Gln Asn 
        195                 200                 205             


Thr Thr Asp Pro Tyr Leu Thr Asn Ser Tyr Val Leu Tyr Ser Lys Arg 
    210                 215                 220                 


Phe Arg Ser Thr Phe Asp Ala Leu Arg Lys Ala Phe Trp Gly His Leu 
225                 230                 235                 240 


Ala His Ala His Gly Lys His Phe Arg Leu Arg Cys Leu Pro His Phe 
                245                 250                 255     


Tyr Ile Ile Gly Gln Pro Lys Cys Gly Thr Thr Asp Leu Tyr Asp Arg 
            260                 265                 270         


Leu Arg Leu His Pro Glu Val Lys Phe Ser Ala Ile Lys Glu Pro His 
        275                 280                 285             


Trp Trp Thr Arg Lys Arg Phe Gly Ile Val Arg Leu Arg Asp Gly Leu 
    290                 295                 300                 


Arg Asp Arg Tyr Pro Val Glu Asp Tyr Leu Asp Leu Phe Asp Leu Ala 
305                 310                 315                 320 


Ala His Gln Ile His Gln Gly Leu Gln Ala Ser Ser Ala Lys Glu Gln 
                325                 330                 335     


Ser Lys Met Asn Thr Ile Ile Ile Gly Glu Ala Ser Ala Ser Thr Met 
            340                 345                 350         


Trp Asp Asn Asn Ala Trp Thr Phe Phe Tyr Asp Asn Ser Thr Asp Gly 
        355                 360                 365             


Glu Pro Pro Phe Leu Thr Gln Asp Phe Ile His Ala Phe Gln Pro Asn 
    370                 375                 380                 


Ala Arg Leu Ile Val Met Leu Arg Asp Pro Val Glu Arg Leu Tyr Ser 
385                 390                 395                 400 


Asp Tyr Leu Tyr Phe Ala Ser Ser Asn Lys Ser Ala Asp Asp Phe His 
                405                 410                 415     


Glu Lys Val Thr Glu Ala Leu Gln Leu Phe Glu Asn Cys Met Leu Asp 
            420                 425                 430         


Tyr Ser Leu Arg Ala Cys Val Tyr Asn Asn Thr Leu Asn Asn Ala Met 
        435                 440                 445             


Pro Val Cys Thr Pro Pro Pro Arg Thr Pro Arg Ala Gly Pro Trp Gln 
    450                 455                 460                 


Lys Glu Leu Val Cys Cys Tyr Tyr Ala Ser Gly Ile Val Gly Leu Arg 
465                 470                 475                 480 


Phe Ser Ile Gly Thr Glu Arg Ser Val Leu Met Cys Lys Cys Cys Ser 
                485                 490                 495     


Pro Leu Phe Met Asp Val Lys Ala Glu Asn 
            500                 505     


<210>  2180
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST1__Homo_sapiens__NP_003645

<400>  2180

Met Gln Cys Ser Trp Lys Ala Val Leu Leu Leu Ala Leu Ala Ser Ile 
1               5                   10                  15      


Ala Ile Gln Tyr Thr Ala Ile Arg Thr Phe Thr Ala Lys Ser Phe His 
            20                  25                  30          


Thr Cys Pro Gly Leu Ala Glu Ala Gly Leu Ala Glu Arg Leu Cys Glu 
        35                  40                  45              


Glu Ser Pro Thr Phe Ala Tyr Asn Leu Ser Arg Lys Thr His Ile Leu 
    50                  55                  60                  


Ile Leu Ala Thr Thr Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe 
65                  70                  75                  80  


Asn Gln His Leu Asp Val Phe Tyr Leu Phe Glu Pro Leu Tyr His Val 
                85                  90                  95      


Gln Asn Thr Leu Ile Pro Arg Phe Thr Gln Gly Lys Ser Pro Ala Asp 
            100                 105                 110         


Arg Arg Val Met Leu Gly Ala Ser Arg Asp Leu Leu Arg Ser Leu Tyr 
        115                 120                 125             


Asp Cys Asp Leu Tyr Phe Leu Glu Asn Tyr Ile Lys Pro Pro Pro Val 
    130                 135                 140                 


Asn His Thr Thr Asp Arg Ile Phe Arg Arg Gly Ala Ser Arg Val Leu 
145                 150                 155                 160 


Cys Ser Arg Pro Val Cys Asp Pro Pro Gly Pro Ala Asp Leu Val Leu 
                165                 170                 175     


Glu Glu Gly Asp Cys Val Arg Lys Cys Gly Leu Leu Asn Leu Thr Val 
            180                 185                 190         


Ala Ala Glu Ala Cys Arg Glu Arg Ser His Val Ala Ile Lys Thr Val 
        195                 200                 205             


Arg Val Pro Glu Val Asn Asp Leu Arg Ala Leu Val Glu Asp Pro Arg 
    210                 215                 220                 


Leu Asn Leu Lys Val Ile Gln Leu Val Arg Asp Pro Arg Gly Ile Leu 
225                 230                 235                 240 


Ala Ser Arg Ser Glu Thr Phe Arg Asp Thr Tyr Arg Leu Trp Arg Leu 
                245                 250                 255     


Trp Tyr Gly Thr Gly Arg Lys Pro Tyr Asn Leu Asp Val Thr Gln Leu 
            260                 265                 270         


Thr Thr Val Cys Glu Asp Phe Ser Asn Ser Val Ser Thr Gly Leu Met 
        275                 280                 285             


Arg Pro Pro Trp Leu Lys Gly Lys Tyr Met Leu Val Arg Tyr Glu Asp 
    290                 295                 300                 


Leu Ala Arg Asn Pro Met Lys Lys Thr Glu Glu Ile Tyr Gly Phe Leu 
305                 310                 315                 320 


Gly Ile Pro Leu Asp Ser His Val Ala Arg Trp Ile Gln Asn Asn Thr 
                325                 330                 335     


Arg Gly Asp Pro Thr Leu Gly Lys His Lys Tyr Gly Thr Val Arg Asn 
            340                 345                 350         


Ser Ala Ala Thr Ala Glu Lys Trp Arg Phe Arg Leu Ser Tyr Asp Ile 
        355                 360                 365             


Val Ala Phe Ala Gln Asn Ala Cys Gln Gln Val Leu Ala Gln Leu Gly 
    370                 375                 380                 


Tyr Lys Ile Ala Ala Ser Glu Glu Glu Leu Lys Asn Pro Ser Val Ser 
385                 390                 395                 400 


Leu Val Glu Glu Arg Asp Phe Arg Pro Phe Ser 
                405                 410     


<210>  2181
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST2__Homo_sapiens__NP_004258

<400>  2181

Met Ser Arg Ser Pro Gln Arg Ala Leu Pro Pro Gly Ala Leu Pro Arg 
1               5                   10                  15      


Leu Leu Gln Ala Ala Pro Ala Ala Ala Pro Arg Ala Leu Leu Pro Gln 
            20                  25                  30          


Trp Pro Arg Arg Pro Gly Arg Arg Trp Pro Ala Ser Pro Leu Gly Met 
        35                  40                  45              


Lys Val Phe Arg Arg Lys Ala Leu Val Leu Cys Ala Gly Tyr Ala Leu 
    50                  55                  60                  


Leu Leu Val Leu Thr Met Leu Asn Leu Leu Asp Tyr Lys Trp His Lys 
65                  70                  75                  80  


Glu Pro Leu Gln Gln Cys Asn Pro Asp Gly Pro Leu Gly Ala Ala Ala 
                85                  90                  95      


Gly Ala Ala Gly Gly Ser Trp Gly Arg Pro Gly Pro Pro Pro Ala Gly 
            100                 105                 110         


Pro Pro Arg Ala His Ala Arg Leu Asp Leu Arg Thr Pro Tyr Arg Pro 
        115                 120                 125             


Pro Ala Ala Ala Val Gly Ala Ala Pro Ala Ala Ala Ala Gly Met Ala 
    130                 135                 140                 


Gly Val Ala Ala Pro Pro Gly Asn Gly Thr Arg Gly Thr Gly Gly Val 
145                 150                 155                 160 


Gly Asp Lys Arg Gln Leu Val Tyr Val Phe Thr Thr Trp Arg Ser Gly 
                165                 170                 175     


Ser Ser Phe Phe Gly Glu Leu Phe Asn Gln Asn Pro Glu Val Phe Phe 
            180                 185                 190         


Leu Tyr Glu Pro Val Trp His Val Trp Gln Lys Leu Tyr Pro Gly Asp 
        195                 200                 205             


Ala Val Ser Leu Gln Gly Ala Ala Arg Asp Met Leu Ser Ala Leu Tyr 
    210                 215                 220                 


Arg Cys Asp Leu Ser Val Phe Gln Leu Tyr Ser Pro Ala Gly Ser Gly 
225                 230                 235                 240 


Gly Arg Asn Leu Thr Thr Leu Gly Ile Phe Gly Ala Ala Thr Asn Lys 
                245                 250                 255     


Val Val Cys Ser Ser Pro Leu Cys Pro Ala Tyr Arg Lys Glu Val Val 
            260                 265                 270         


Gly Leu Val Asp Asp Arg Val Cys Lys Lys Cys Pro Pro Gln Arg Leu 
        275                 280                 285             


Ala Arg Phe Glu Glu Glu Cys Arg Lys Tyr Arg Thr Leu Val Ile Lys 
    290                 295                 300                 


Gly Val Arg Val Phe Asp Val Ala Val Leu Ala Pro Leu Leu Arg Asp 
305                 310                 315                 320 


Pro Ala Leu Asp Leu Lys Val Ile His Leu Val Arg Asp Pro Arg Ala 
                325                 330                 335     


Val Ala Ser Ser Arg Ile Arg Ser Arg His Gly Leu Ile Arg Glu Ser 
            340                 345                 350         


Leu Gln Val Val Arg Ser Arg Asp Pro Arg Ala His Arg Met Pro Phe 
        355                 360                 365             


Leu Glu Ala Ala Gly His Lys Leu Gly Ala Lys Lys Glu Gly Val Gly 
    370                 375                 380                 


Gly Pro Ala Asp Tyr His Ala Leu Gly Ala Met Glu Val Ile Cys Asn 
385                 390                 395                 400 


Ser Met Ala Lys Thr Leu Gln Thr Ala Leu Gln Pro Pro Asp Trp Leu 
                405                 410                 415     


Gln Gly His Tyr Leu Val Val Arg Tyr Glu Asp Leu Val Gly Asp Pro 
            420                 425                 430         


Val Lys Thr Leu Arg Arg Val Tyr Asp Phe Val Gly Leu Leu Val Ser 
        435                 440                 445             


Pro Glu Met Glu Gln Phe Ala Leu Asn Met Thr Ser Gly Ser Gly Ser 
    450                 455                 460                 


Ser Ser Lys Pro Phe Val Val Ser Ala Arg Asn Ala Thr Gln Ala Ala 
465                 470                 475                 480 


Asn Ala Trp Arg Thr Ala Leu Thr Phe Gln Gln Ile Lys Gln Val Glu 
                485                 490                 495     


Glu Phe Cys Tyr Gln Pro Met Ala Val Leu Gly Tyr Glu Arg Val Asn 
            500                 505                 510         


Ser Pro Glu Glu Val Lys Asp Leu Ser Lys Thr Leu Leu Arg Lys Pro 
        515                 520                 525             


Arg Leu 
    530 


<210>  2182
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST3__Homo_sapiens__XP_006718138

<400>  2182

Met Glu Lys Gly Leu Thr Leu Pro Gln Asp Cys Arg Asp Phe Val His 
1               5                   10                  15      


Ser Leu Lys Met Arg Ser Lys Tyr Ala Leu Phe Leu Val Phe Val Val 
            20                  25                  30          


Ile Val Phe Val Phe Ile Glu Lys Glu Asn Lys Ile Ile Ser Arg Val 
        35                  40                  45              


Ser Asp Lys Leu Lys Gln Ile Pro Gln Ala Leu Ala Asp Ala Asn Ser 
    50                  55                  60                  


Thr Asp Pro Ala Leu Ile Leu Ala Glu Asn Ala Ser Leu Leu Ser Leu 
65                  70                  75                  80  


Ser Glu Leu Asp Ser Ala Phe Ser Gln Leu Gln Ser Arg Leu Arg Asn 
                85                  90                  95      


Leu Ser Leu Gln Leu Gly Val Glu Pro Ala Met Glu Ala Ala Gly Glu 
            100                 105                 110         


Glu Glu Glu Glu Gln Arg Lys Glu Glu Glu Pro Pro Arg Pro Ala Val 
        115                 120                 125             


Ala Gly Pro Arg Arg His Val Leu Leu Met Ala Thr Thr Arg Thr Gly 
    130                 135                 140                 


Ser Ser Phe Val Gly Glu Phe Phe Asn Gln Gln Gly Asn Ile Phe Tyr 
145                 150                 155                 160 


Leu Phe Glu Pro Leu Trp His Ile Glu Arg Thr Val Ser Phe Glu Pro 
                165                 170                 175     


Gly Gly Ala Asn Ala Ala Gly Ser Ala Leu Val Tyr Arg Asp Val Leu 
            180                 185                 190         


Lys Gln Leu Phe Leu Cys Asp Leu Tyr Val Leu Glu His Phe Ile Thr 
        195                 200                 205             


Pro Leu Pro Glu Asp His Leu Thr Gln Phe Met Phe Arg Arg Gly Ser 
    210                 215                 220                 


Ser Arg Ser Leu Cys Glu Asp Pro Val Cys Thr Pro Phe Val Lys Lys 
225                 230                 235                 240 


Val Phe Glu Lys Tyr His Cys Lys Asn Arg Arg Cys Gly Pro Leu Asn 
                245                 250                 255     


Val Thr Leu Ala Ala Glu Ala Cys Arg Arg Lys Glu His Met Ala Leu 
            260                 265                 270         


Lys Ala Val Arg Ile Arg Gln Leu Glu Phe Leu Gln Pro Leu Ala Glu 
        275                 280                 285             


Asp Pro Arg Leu Asp Leu Arg Val Ile Gln Leu Val Arg Asp Pro Arg 
    290                 295                 300                 


Ala Val Leu Ala Ser Arg Met Val Ala Phe Ala Gly Lys Tyr Lys Thr 
305                 310                 315                 320 


Trp Lys Lys Trp Leu Asp Asp Glu Gly Gln Asp Gly Leu Arg Glu Glu 
                325                 330                 335     


Glu Val Gln Arg Leu Arg Gly Asn Cys Glu Ser Ile Arg Leu Ser Ala 
            340                 345                 350         


Glu Leu Gly Leu Arg Gln Pro Ala Trp Leu Arg Gly Arg Tyr Met Leu 
        355                 360                 365             


Val Arg Tyr Glu Asp Val Ala Arg Gly Pro Leu Gln Lys Ala Arg Glu 
    370                 375                 380                 


Met Tyr Arg Phe Ala Gly Ile Pro Leu Thr Pro Gln Val Glu Asp Trp 
385                 390                 395                 400 


Ile Gln Lys Asn Thr Gln Ala Ala His Asp Gly Ser Gly Ile Tyr Ser 
                405                 410                 415     


Thr Gln Lys Asn Ser Ser Glu Gln Phe Glu Lys Trp Arg Phe Ser Met 
            420                 425                 430         


Pro Phe Lys Leu Ala Gln Val Val Gln Ala Ala Cys Gly Pro Ala Met 
        435                 440                 445             


Arg Leu Phe Gly Tyr Lys Leu Ala Arg Asp Ala Ala Ala Leu Thr Asn 
    450                 455                 460                 


Arg Ser Val Ser Leu Leu Glu Glu Arg Gly Thr Phe Trp Val Thr 
465                 470                 475                 


<210>  2183
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST4__Homo_sapiens__NP_005760

<400>  2183

Met Leu Leu Pro Lys Lys Met Lys Leu Leu Leu Phe Leu Val Ser Gln 
1               5                   10                  15      


Met Ala Ile Leu Ala Leu Phe Phe His Met Tyr Ser His Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Met Lys Ala Gln Pro Glu Arg Met His Val Leu Val Leu 
        35                  40                  45              


Ser Ser Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Gly Gln 
    50                  55                  60                  


His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Met 
65                  70                  75                  80  


Thr Phe Lys Gln Ser Thr Ala Trp Met Leu His Met Ala Val Arg Asp 
                85                  90                  95      


Leu Ile Arg Ala Val Phe Leu Cys Asp Met Ser Val Phe Asp Ala Tyr 
            100                 105                 110         


Met Glu Pro Gly Pro Arg Arg Gln Ser Ser Leu Phe Gln Trp Glu Asn 
        115                 120                 125             


Ser Arg Ala Leu Cys Ser Ala Pro Ala Cys Asp Ile Ile Pro Gln Asp 
    130                 135                 140                 


Glu Ile Ile Pro Arg Ala His Cys Arg Leu Leu Cys Ser Gln Gln Pro 
145                 150                 155                 160 


Phe Glu Val Val Glu Lys Ala Cys Arg Ser Tyr Ser His Val Val Leu 
                165                 170                 175     


Lys Glu Val Arg Phe Phe Asn Leu Gln Ser Leu Tyr Pro Leu Leu Lys 
            180                 185                 190         


Asp Pro Ser Leu Asn Leu His Ile Val His Leu Val Arg Asp Pro Arg 
        195                 200                 205             


Ala Val Phe Arg Ser Arg Glu Arg Thr Lys Gly Asp Leu Met Ile Asp 
    210                 215                 220                 


Ser Arg Ile Val Met Gly Gln His Glu Gln Lys Leu Lys Lys Glu Asp 
225                 230                 235                 240 


Gln Pro Tyr Tyr Val Met Gln Val Ile Cys Gln Ser Gln Leu Glu Ile 
                245                 250                 255     


Tyr Lys Thr Ile Gln Ser Leu Pro Lys Ala Leu Gln Glu Arg Tyr Leu 
            260                 265                 270         


Leu Val Arg Tyr Glu Asp Leu Ala Arg Ala Pro Val Ala Gln Thr Ser 
        275                 280                 285             


Arg Met Tyr Glu Phe Val Gly Leu Glu Phe Leu Pro His Leu Gln Thr 
    290                 295                 300                 


Trp Val His Asn Ile Thr Arg Gly Lys Gly Met Gly Asp His Ala Phe 
305                 310                 315                 320 


His Thr Asn Ala Arg Asp Ala Leu Asn Val Ser Gln Ala Trp Arg Trp 
                325                 330                 335     


Ser Leu Pro Tyr Glu Lys Val Ser Arg Leu Gln Lys Ala Cys Gly Asp 
            340                 345                 350         


Ala Met Asn Leu Leu Gly Tyr Arg His Val Arg Ser Glu Gln Glu Gln 
        355                 360                 365             


Arg Asn Leu Leu Leu Asp Leu Leu Ser Thr Trp Thr Val Pro Glu Gln 
    370                 375                 380                 


Ile His 
385     


<210>  2184
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST5__Homo_sapiens__NP_078809

<400>  2184

Met Gly Met Arg Ala Arg Val Pro Lys Val Ala His Ser Thr Arg Arg 
1               5                   10                  15      


Pro Pro Ala Ala Arg Met Trp Leu Pro Arg Phe Ser Ser Lys Thr Val 
            20                  25                  30          


Thr Val Leu Leu Leu Ala Gln Thr Thr Cys Leu Leu Leu Phe Ile Ile 
        35                  40                  45              


Ser Arg Pro Gly Pro Ser Ser Pro Ala Gly Gly Glu Asp Arg Val His 
    50                  55                  60                  


Val Leu Val Leu Ser Ser Trp Arg Ser Gly Ser Ser Phe Leu Gly Gln 
65                  70                  75                  80  


Leu Phe Ser Gln His Pro Asp Val Phe Tyr Leu Met Glu Pro Ala Trp 
                85                  90                  95      


His Val Trp Thr Thr Leu Ser Gln Gly Ser Ala Ala Thr Leu His Met 
            100                 105                 110         


Ala Val Arg Asp Leu Met Arg Ser Ile Phe Leu Cys Asp Met Asp Val 
        115                 120                 125             


Phe Asp Ala Tyr Met Pro Gln Ser Arg Asn Leu Ser Ala Phe Phe Asn 
    130                 135                 140                 


Trp Ala Thr Ser Arg Ala Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe 
145                 150                 155                 160 


Pro Arg Gly Thr Ile Ser Lys Gln Asp Val Cys Lys Thr Leu Cys Thr 
                165                 170                 175     


Arg Gln Pro Phe Ser Leu Ala Arg Glu Ala Cys Arg Ser Tyr Ser His 
            180                 185                 190         


Val Val Leu Lys Glu Val Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro 
        195                 200                 205             


Leu Leu Ser Asp Pro Ala Leu Asn Leu Arg Ile Val His Leu Val Arg 
    210                 215                 220                 


Asp Pro Arg Ala Val Leu Arg Ser Arg Glu Ala Ala Gly Pro Ile Leu 
225                 230                 235                 240 


Ala Arg Asp Asn Gly Ile Val Leu Gly Thr Asn Gly Lys Trp Val Glu 
                245                 250                 255     


Ala Asp Pro His Leu Arg Leu Ile Arg Glu Val Cys Arg Ser His Val 
            260                 265                 270         


Arg Ile Ala Glu Ala Ala Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly 
        275                 280                 285             


Arg Tyr Arg Leu Val Arg Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala 
    290                 295                 300                 


Glu Ile Arg Ala Leu Tyr Ala Phe Thr Gly Leu Thr Leu Thr Pro Gln 
305                 310                 315                 320 


Leu Glu Ala Trp Ile His Asn Ile Thr His Gly Ser Gly Ile Gly Lys 
                325                 330                 335     


Pro Ile Glu Ala Phe His Thr Ser Ser Arg Asn Ala Arg Asn Val Ser 
            340                 345                 350         


Gln Ala Trp Arg His Ala Leu Pro Phe Thr Lys Ile Leu Arg Val Gln 
        355                 360                 365             


Glu Val Cys Ala Gly Ala Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr 
    370                 375                 380                 


Ser Ala Asp Gln Gln Arg Asp Leu Thr Leu Asp Leu Val Leu Pro Arg 
385                 390                 395                 400 


Gly Pro Asp His Phe Ser Trp Ala Ser Pro Asp 
                405                 410     


<210>  2185
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST6__Homo_sapiens__XP_011521387

<400>  2185

Met Trp Leu Pro Arg Val Ser Ser Thr Ala Val Thr Ala Leu Leu Leu 
1               5                   10                  15      


Ala Gln Thr Phe Leu Leu Leu Phe Leu Val Ser Arg Pro Gly Pro Ser 
            20                  25                  30          


Ser Pro Ala Gly Gly Glu Ala Arg Val His Val Leu Val Leu Ser Ser 
        35                  40                  45              


Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Asn Gln His Pro 
    50                  55                  60                  


Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Thr Thr Leu 
65                  70                  75                  80  


Ser Gln Gly Ser Ala Ala Thr Leu His Met Ala Val Arg Asp Leu Val 
                85                  90                  95      


Arg Ser Val Phe Leu Cys Asp Met Asp Val Phe Asp Ala Tyr Leu Pro 
            100                 105                 110         


Trp Arg Arg Asn Leu Ser Asp Leu Phe Gln Trp Ala Val Ser Arg Ala 
        115                 120                 125             


Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe Pro Arg Gly Ala Ile Ser 
    130                 135                 140                 


Ser Glu Ala Val Cys Lys Pro Leu Cys Ala Arg Gln Ser Phe Thr Leu 
145                 150                 155                 160 


Ala Arg Glu Ala Cys Arg Ser Tyr Ser His Val Val Leu Lys Glu Val 
                165                 170                 175     


Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro Leu Leu Ser Asp Pro Ala 
            180                 185                 190         


Leu Asn Leu Arg Ile Val His Leu Val Arg Asp Pro Arg Ala Val Leu 
        195                 200                 205             


Arg Ser Arg Glu Gln Thr Ala Lys Ala Leu Ala Arg Asp Asn Gly Ile 
    210                 215                 220                 


Val Leu Gly Thr Asn Gly Thr Trp Val Glu Ala Asp Pro Gly Leu Arg 
225                 230                 235                 240 


Val Val Arg Glu Val Cys Arg Ser His Val Arg Ile Ala Glu Ala Ala 
                245                 250                 255     


Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly Arg Tyr Arg Leu Val Arg 
            260                 265                 270         


Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala Glu Ile Arg Ala Leu Tyr 
        275                 280                 285             


Ala Phe Thr Gly Leu Ser Leu Thr Pro Gln Leu Glu Ala Trp Ile His 
    290                 295                 300                 


Asn Ile Thr His Gly Ser Gly Pro Gly Ala Arg Arg Glu Ala Phe Lys 
305                 310                 315                 320 


Thr Ser Ser Arg Asn Ala Leu Asn Val Ser Gln Ala Trp Arg His Ala 
                325                 330                 335     


Leu Pro Phe Ala Lys Ile Arg Arg Val Gln Glu Leu Cys Ala Gly Ala 
            340                 345                 350         


Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr Ser Glu Asp Glu Gln Arg 
        355                 360                 365             


Asn Leu Ala Leu Asp Leu Val Leu Pro Arg Gly Leu Asn Gly Phe Thr 
    370                 375                 380                 


Trp Ala Ser Ser Thr Ala Ser His Pro Arg Asn 
385                 390                 395 


<210>  2186
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST8__Homo_sapiens__XP_011525528

<400>  2186

Met Thr Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser 
1               5                   10                  15      


Ile Leu Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln 
            20                  25                  30          


Asp Pro Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn 
        35                  40                  45              


Ile Arg Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln 
    50                  55                  60                  


Asp Gly Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln 
                85                  90                  95      


Pro Pro Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg 
            100                 105                 110         


Arg Leu Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn 
        115                 120                 125             


Ser Ser Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly 
    130                 135                 140                 


Arg Trp Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met 
145                 150                 155                 160 


Gln Glu Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val 
                165                 170                 175     


Thr Pro Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val 
            180                 185                 190         


Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val 
        195                 200                 205             


Leu Met Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His 
    210                 215                 220                 


Asn Thr Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp 
225                 230                 235                 240 


Arg Gln Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe 
                245                 250                 255     


Val Arg Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe 
            260                 265                 270         


Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu 
        275                 280                 285             


Ala Arg Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser 
    290                 295                 300                 


Gly Val Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg 
305                 310                 315                 320 


Pro Val Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser 
                325                 330                 335     


Pro Cys Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu 
            340                 345                 350         


Asp Asp Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu 
        355                 360                 365             


Thr Phe Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr 
    370                 375                 380                 


Ala Arg Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg 
385                 390                 395                 400 


Gln Arg Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr 
                405                 410                 415     


Ser Lys Pro Phe Ala Asp Leu Tyr 
            420                 


<210>  2187
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHST9__Homo_sapiens__NP_001243245

<400>  2187

Met Gln Pro Ser Glu Met Val Met Asn Pro Lys Gln Val Phe Leu Ser 
1               5                   10                  15      


Val Leu Ile Phe Gly Val Ala Gly Leu Leu Leu Phe Met Tyr Leu Gln 
            20                  25                  30          


Val Trp Ile Glu Glu Gln His Thr Gly Arg Val Glu Lys Arg Arg Glu 
        35                  40                  45              


Gln Lys Val Thr Ser Gly Trp Gly Pro Val Lys Tyr Leu Arg Pro Val 
    50                  55                  60                  


Pro Arg Ile Lys Pro Gln Val Ser His Ala 
65                  70                  


<210>  2188
<211>  802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHSY1__Homo_sapiens__NP_055733

<400>  2188

Met Ala Ala Arg Gly Arg Arg Ala Trp Leu Ser Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Val Leu Ala Ser Arg Leu Val Leu Pro Arg Ala Ser 
            20                  25                  30          


Glu Leu Lys Arg Ala Gly Pro Arg Arg Arg Ala Ser Pro Glu Gly Cys 
        35                  40                  45              


Arg Ser Gly Gln Ala Ala Ala Ser Gln Ala Gly Gly Ala Arg Gly Asp 
    50                  55                  60                  


Ala Arg Gly Ala Gln Leu Trp Pro Pro Gly Ser Asp Pro Asp Gly Gly 
65                  70                  75                  80  


Pro Arg Asp Arg Asn Phe Leu Phe Val Gly Val Met Thr Ala Gln Lys 
                85                  90                  95      


Tyr Leu Gln Thr Arg Ala Val Ala Ala Tyr Arg Thr Trp Ser Lys Thr 
            100                 105                 110         


Ile Pro Gly Lys Val Gln Phe Phe Ser Ser Glu Gly Ser Asp Thr Ser 
        115                 120                 125             


Val Pro Ile Pro Val Val Pro Leu Arg Gly Val Asp Asp Ser Tyr Pro 
    130                 135                 140                 


Pro Gln Lys Lys Ser Phe Met Met Leu Lys Tyr Met His Asp His Tyr 
145                 150                 155                 160 


Leu Asp Lys Tyr Glu Trp Phe Met Arg Ala Asp Asp Asp Val Tyr Ile 
                165                 170                 175     


Lys Gly Asp Arg Leu Glu Asn Phe Leu Arg Ser Leu Asn Ser Ser Glu 
            180                 185                 190         


Pro Leu Phe Leu Gly Gln Thr Gly Leu Gly Thr Thr Glu Glu Met Gly 
        195                 200                 205             


Lys Leu Ala Leu Glu Pro Gly Glu Asn Phe Cys Met Gly Gly Pro Gly 
    210                 215                 220                 


Val Ile Met Ser Arg Glu Val Leu Arg Arg Met Val Pro His Ile Gly 
225                 230                 235                 240 


Lys Cys Leu Arg Glu Met Tyr Thr Thr His Glu Asp Val Glu Val Gly 
                245                 250                 255     


Arg Cys Val Arg Arg Phe Ala Gly Val Gln Cys Val Trp Ser Tyr Glu 
            260                 265                 270         


Met Gln Gln Leu Phe Tyr Glu Asn Tyr Glu Gln Asn Lys Lys Gly Tyr 
        275                 280                 285             


Ile Arg Asp Leu His Asn Ser Lys Ile His Gln Ala Ile Thr Leu His 
    290                 295                 300                 


Pro Asn Lys Asn Pro Pro Tyr Gln Tyr Arg Leu His Ser Tyr Met Leu 
305                 310                 315                 320 


Ser Arg Lys Ile Ser Glu Leu Arg His Arg Thr Ile Gln Leu His Arg 
                325                 330                 335     


Glu Ile Val Leu Met Ser Lys Tyr Ser Asn Thr Glu Ile His Lys Glu 
            340                 345                 350         


Asp Leu Gln Leu Gly Ile Pro Pro Ser Phe Met Arg Phe Gln Pro Arg 
        355                 360                 365             


Gln Arg Glu Glu Ile Leu Glu Trp Glu Phe Leu Thr Gly Lys Tyr Leu 
    370                 375                 380                 


Tyr Ser Ala Val Asp Gly Gln Pro Pro Arg Arg Gly Met Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Glu Ala Leu Asp Asp Ile Val Met Gln Val Met Glu Met Ile 
                405                 410                 415     


Asn Ala Asn Ala Lys Thr Arg Gly Arg Ile Ile Asp Phe Lys Glu Ile 
            420                 425                 430         


Gln Tyr Gly Tyr Arg Arg Val Asn Pro Met Tyr Gly Ala Glu Tyr Ile 
        435                 440                 445             


Leu Asp Leu Leu Leu Leu Tyr Lys Lys His Lys Gly Lys Lys Met Thr 
    450                 455                 460                 


Val Pro Val Arg Arg His Ala Tyr Leu Gln Gln Thr Phe Ser Lys Ile 
465                 470                 475                 480 


Gln Phe Val Glu His Glu Glu Leu Asp Ala Gln Glu Leu Ala Lys Arg 
                485                 490                 495     


Ile Asn Gln Glu Ser Gly Ser Leu Ser Phe Leu Ser Asn Ser Leu Lys 
            500                 505                 510         


Lys Leu Val Pro Phe Gln Leu Pro Gly Ser Lys Ser Glu His Lys Glu 
        515                 520                 525             


Pro Lys Asp Lys Lys Ile Asn Ile Leu Ile Pro Leu Ser Gly Arg Phe 
    530                 535                 540                 


Asp Met Phe Val Arg Phe Met Gly Asn Phe Glu Lys Thr Cys Leu Ile 
545                 550                 555                 560 


Pro Asn Gln Asn Val Lys Leu Val Val Leu Leu Phe Asn Ser Asp Ser 
                565                 570                 575     


Asn Pro Asp Lys Ala Lys Gln Val Glu Leu Met Arg Asp Tyr Arg Ile 
            580                 585                 590         


Lys Tyr Pro Lys Ala Asp Met Gln Ile Leu Pro Val Ser Gly Glu Phe 
        595                 600                 605             


Ser Arg Ala Leu Ala Leu Glu Val Gly Ser Ser Gln Phe Asn Asn Glu 
    610                 615                 620                 


Ser Leu Leu Phe Phe Cys Asp Val Asp Leu Val Phe Thr Thr Glu Phe 
625                 630                 635                 640 


Leu Gln Arg Cys Arg Ala Asn Thr Val Leu Gly Gln Gln Ile Tyr Phe 
                645                 650                 655     


Pro Ile Ile Phe Ser Gln Tyr Asp Pro Lys Ile Val Tyr Ser Gly Lys 
            660                 665                 670         


Val Pro Ser Asp Asn His Phe Ala Phe Thr Gln Lys Thr Gly Phe Trp 
        675                 680                 685             


Arg Asn Tyr Gly Phe Gly Ile Thr Cys Ile Tyr Lys Gly Asp Leu Val 
    690                 695                 700                 


Arg Val Gly Gly Phe Asp Val Ser Ile Gln Gly Trp Gly Leu Glu Asp 
705                 710                 715                 720 


Val Asp Leu Phe Asn Lys Val Val Gln Ala Gly Leu Lys Thr Phe Arg 
                725                 730                 735     


Ser Gln Glu Val Gly Val Val His Val His His Pro Val Phe Cys Asp 
            740                 745                 750         


Pro Asn Leu Asp Pro Lys Gln Tyr Lys Met Cys Leu Gly Ser Lys Ala 
        755                 760                 765             


Ser Thr Tyr Gly Ser Thr Gln Gln Leu Ala Glu Met Trp Leu Glu Lys 
    770                 775                 780                 


Asn Asp Pro Ser Tyr Ser Lys Ser Ser Asn Asn Asn Gly Ser Val Arg 
785                 790                 795                 800 


Thr Ala 
        


<210>  2189
<211>  882
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHSY3__Homo_sapiens__NP_787052

<400>  2189

Met Ala Val Arg Ser Arg Arg Pro Trp Met Ser Val Ala Leu Gly Leu 
1               5                   10                  15      


Val Leu Gly Phe Thr Ala Ala Ser Trp Leu Ile Ala Pro Arg Val Ala 
            20                  25                  30          


Glu Leu Ser Glu Arg Lys Arg Arg Gly Ser Ser Leu Cys Ser Tyr Tyr 
        35                  40                  45              


Gly Arg Ser Ala Ala Gly Pro Arg Ala Gly Ala Gln Gln Pro Leu Pro 
    50                  55                  60                  


Gln Pro Gln Ser Arg Pro Arg Gln Glu Gln Ser Pro Pro Pro Ala Arg 
65                  70                  75                  80  


Gln Asp Leu Gln Gly Pro Pro Leu Pro Glu Ala Ala Pro Gly Ile Thr 
                85                  90                  95      


Ser Phe Arg Ser Ser Pro Trp Gln Gln Pro Pro Pro Leu Gln Gln Arg 
            100                 105                 110         


Arg Arg Gly Arg Glu Pro Glu Gly Ala Thr Gly Leu Pro Gly Ala Pro 
        115                 120                 125             


Ala Ala Glu Gly Glu Pro Glu Glu Glu Asp Gly Gly Ala Ala Gly Gln 
    130                 135                 140                 


Arg Arg Asp Gly Arg Pro Gly Ser Ser His Asn Gly Ser Gly Asp Gly 
145                 150                 155                 160 


Gly Ala Ala Ala Pro Ser Ala Arg Pro Arg Asp Phe Leu Tyr Val Gly 
                165                 170                 175     


Val Met Thr Ala Gln Lys Tyr Leu Gly Ser Arg Ala Leu Ala Ala Gln 
            180                 185                 190         


Arg Thr Trp Ala Arg Phe Ile Pro Gly Arg Val Glu Phe Phe Ser Ser 
        195                 200                 205             


Gln Gln Pro Pro Asn Ala Gly Gln Pro Pro Pro Pro Leu Pro Val Ile 
    210                 215                 220                 


Ala Leu Pro Gly Val Asp Asp Ser Tyr Pro Pro Gln Lys Lys Ser Phe 
225                 230                 235                 240 


Met Met Ile Lys Tyr Met His Asp His Tyr Leu Asp Lys Tyr Glu Trp 
                245                 250                 255     


Phe Met Arg Ala Asp Asp Asp Val Tyr Ile Lys Gly Asp Lys Leu Glu 
            260                 265                 270         


Glu Phe Leu Arg Ser Leu Asn Ser Ser Lys Pro Leu Tyr Leu Gly Gln 
        275                 280                 285             


Thr Gly Leu Gly Asn Ile Glu Glu Leu Gly Lys Leu Gly Leu Glu Pro 
    290                 295                 300                 


Gly Glu Asn Phe Cys Met Gly Gly Pro Gly Met Ile Phe Ser Arg Glu 
305                 310                 315                 320 


Val Leu Arg Arg Met Val Pro His Ile Gly Glu Cys Leu Arg Glu Met 
                325                 330                 335     


Tyr Thr Thr His Glu Asp Val Glu Val Gly Arg Cys Val Arg Arg Phe 
            340                 345                 350         


Gly Gly Thr Gln Cys Val Trp Ser Tyr Glu Met Gln Gln Leu Phe His 
        355                 360                 365             


Glu Asn Tyr Glu His Asn Arg Lys Gly Tyr Ile Gln Asp Leu His Asn 
    370                 375                 380                 


Ser Lys Ile His Ala Ala Ile Thr Leu His Pro Asn Lys Arg Pro Ala 
385                 390                 395                 400 


Tyr Gln Tyr Arg Leu His Asn Tyr Met Leu Ser Arg Lys Ile Ser Glu 
                405                 410                 415     


Leu Arg Tyr Arg Thr Ile Gln Leu His Arg Glu Ser Ala Leu Met Ser 
            420                 425                 430         


Lys Leu Ser Asn Thr Glu Val Ser Lys Glu Asp Gln Gln Leu Gly Val 
        435                 440                 445             


Ile Pro Ser Phe Asn His Phe Gln Pro Arg Glu Arg Asn Glu Val Ile 
    450                 455                 460                 


Glu Trp Glu Phe Leu Thr Gly Lys Leu Leu Tyr Ser Ala Ala Glu Asn 
465                 470                 475                 480 


Gln Pro Pro Arg Gln Ser Leu Ser Ser Ile Leu Arg Thr Ala Leu Asp 
                485                 490                 495     


Asp Thr Val Leu Gln Val Met Glu Met Ile Asn Glu Asn Ala Lys Ser 
            500                 505                 510         


Arg Gly Arg Leu Ile Asp Phe Lys Glu Ile Gln Tyr Gly Tyr Arg Arg 
        515                 520                 525             


Val Asn Pro Met His Gly Val Glu Tyr Ile Leu Asp Leu Leu Leu Leu 
    530                 535                 540                 


Tyr Lys Arg His Lys Gly Arg Lys Leu Thr Val Pro Val Arg Arg His 
545                 550                 555                 560 


Ala Tyr Leu Gln Gln Leu Phe Ser Lys Pro Phe Phe Arg Glu Thr Glu 
                565                 570                 575     


Glu Leu Asp Val Asn Ser Leu Val Glu Ser Ile Asn Ser Glu Thr Gln 
            580                 585                 590         


Ser Phe Ser Phe Ile Ser Asn Ser Leu Lys Ile Leu Ser Ser Phe Gln 
        595                 600                 605             


Gly Ala Lys Glu Met Gly Gly His Asn Glu Lys Lys Val His Ile Leu 
    610                 615                 620                 


Val Pro Leu Ile Gly Arg Tyr Asp Ile Phe Leu Arg Phe Met Glu Asn 
625                 630                 635                 640 


Phe Glu Asn Met Cys Leu Ile Pro Lys Gln Asn Val Lys Leu Val Ile 
                645                 650                 655     


Ile Leu Phe Ser Arg Asp Ser Gly Gln Asp Ser Ser Lys His Ile Glu 
            660                 665                 670         


Leu Ile Lys Gly Tyr Gln Asn Lys Tyr Pro Lys Ala Glu Met Thr Leu 
        675                 680                 685             


Ile Pro Met Lys Gly Glu Phe Ser Arg Gly Leu Gly Leu Glu Met Ala 
    690                 695                 700                 


Ser Ala Gln Phe Asp Asn Asp Thr Leu Leu Leu Phe Cys Asp Val Asp 
705                 710                 715                 720 


Leu Ile Phe Arg Glu Asp Phe Leu Gln Arg Cys Arg Asp Asn Thr Ile 
                725                 730                 735     


Gln Gly Gln Gln Val Tyr Tyr Pro Ile Ile Phe Ser Gln Tyr Asp Pro 
            740                 745                 750         


Lys Val Thr Asn Gly Gly Asn Pro Pro Thr Asp Asp Tyr Phe Ile Phe 
        755                 760                 765             


Ser Lys Lys Thr Gly Phe Trp Arg Asp Tyr Gly Tyr Gly Ile Thr Cys 
    770                 775                 780                 


Ile Tyr Lys Ser Asp Leu Leu Gly Ala Gly Gly Phe Asp Thr Ser Ile 
785                 790                 795                 800 


Gln Gly Trp Gly Leu Glu Asp Val Asp Leu Tyr Asn Lys Val Ile Leu 
                805                 810                 815     


Ser Gly Leu Arg Pro Phe Arg Ser Gln Glu Val Gly Val Val His Ile 
            820                 825                 830         


Phe His Pro Val His Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys 
        835                 840                 845             


Met Cys Leu Gly Ser Lys Ala Ser Thr Phe Ala Ser Thr Met Gln Leu 
    850                 855                 860                 


Ala Glu Leu Trp Leu Glu Lys His Leu Gly Val Arg Tyr Asn Arg Thr 
865                 870                 875                 880 


Leu Ser 
        


<210>  2190
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHTF18__Homo_sapiens__NP_071375

<400>  2190

Met Glu Asp Tyr Glu Gln Glu Leu Cys Gly Val Glu Asp Asp Phe His 
1               5                   10                  15      


Asn Gln Phe Ala Ala Glu Leu Glu Val Leu Ala Glu Leu Glu Gly Ala 
            20                  25                  30          


Ser Thr Pro Ser Pro Ser Gly Val Pro Leu Phe Thr Ala Gly Arg Pro 
        35                  40                  45              


Pro Arg Thr Phe Glu Glu Ala Leu Ala Arg Gly Asp Ala Ala Ser Ser 
    50                  55                  60                  


Pro Ala Pro Ala Ala Ser Val Gly Ser Ser Gln Gly Gly Ala Arg Lys 
65                  70                  75                  80  


Arg Gln Val Asp Ala Asp Leu Gln Pro Ala Gly Ser Leu Pro His Ala 
                85                  90                  95      


Pro Arg Ile Lys Arg Pro Arg Leu Gln Val Val Lys Arg Leu Asn Phe 
            100                 105                 110         


Arg Ser Glu Glu Met Glu Glu Pro Pro Pro Pro Asp Ser Ser Pro Thr 
        115                 120                 125             


Asp Ile Thr Pro Pro Pro Ser Pro Glu Asp Leu Ala Glu Leu Trp Gly 
    130                 135                 140                 


His Gly Val Ser Glu Ala Ala Ala Asp Val Gly Leu Thr Arg Ala Ser 
145                 150                 155                 160 


Pro Ala Ala Arg Asn Pro Val Leu Arg Arg Pro Pro Ile Leu Glu Asp 
                165                 170                 175     


Tyr Val His Val Thr Ser Thr Glu Gly Val Arg Ala Tyr Leu Val Leu 
            180                 185                 190         


Arg Ala Asp Pro Met Ala Pro Gly Val Gln Gly Ser Leu Leu His Val 
        195                 200                 205             


Pro Trp Arg Gly Gly Gly Gln Leu Asp Leu Leu Gly Val Ser Leu Ala 
    210                 215                 220                 


Ser Leu Lys Lys Gln Val Asp Gly Glu Arg Arg Glu Arg Leu Leu Gln 
225                 230                 235                 240 


Glu Ala Gln Lys Leu Ser Asp Thr Leu His Ser Leu Arg Ser Gly Glu 
                245                 250                 255     


Glu Glu Ala Ala Gln Pro Leu Gly Ala Pro Glu Glu Glu Pro Thr Asp 
            260                 265                 270         


Gly Gln Asp Ala Ser Ser His Cys Leu Trp Val Asp Glu Phe Ala Pro 
        275                 280                 285             


Arg His Tyr Thr Glu Leu Leu Ser Asp Asp Phe Thr Asn Arg Cys Leu 
    290                 295                 300                 


Leu Lys Trp Leu Lys Leu Trp Asp Leu Val Val Phe Gly His Glu Arg 
305                 310                 315                 320 


Pro Ser Arg Lys Pro Arg Pro Ser Val Glu Pro Ala Arg Val Ser Lys 
                325                 330                 335     


Glu Ala Thr Ala Pro Gly Lys Trp Lys Ser His Glu Gln Val Leu Glu 
            340                 345                 350         


Glu Met Leu Glu Ala Gly Leu Asp Pro Ser Gln Arg Pro Lys Gln Lys 
        355                 360                 365             


Val Ala Leu Leu Cys Gly Pro Pro Gly Leu Gly Lys Thr Thr Leu Ala 
    370                 375                 380                 


His Val Ile Ala Arg His Ala Gly Tyr Ser Val Val Glu Met Asn Ala 
385                 390                 395                 400 


Ser Asp Asp Arg Ser Pro Glu Val Phe Arg Thr Arg Ile Glu Ala Ala 
                405                 410                 415     


Thr Gln Met Glu Ser Val Leu Gly Ala Gly Gly Lys Pro Asn Cys Leu 
            420                 425                 430         


Val Ile Asp Glu Ile Asp Gly Ala Pro Val Ala Ala Ile Asn Val Leu 
        435                 440                 445             


Leu Ser Ile Leu Asn Arg Lys Gly Pro Gln Glu Val Gly Pro Gln Gly 
    450                 455                 460                 


Pro Ala Val Pro Ser Gly Gly Gly Arg Arg Arg Arg Ala Glu Gly Gly 
465                 470                 475                 480 


Leu Leu Met Arg Pro Ile Ile Cys Ile Cys Asn Asp Gln Phe Ala Pro 
                485                 490                 495     


Ser Leu Arg Gln Leu Lys Gln Gln Ala Phe Leu Leu His Phe Pro Pro 
            500                 505                 510         


Thr Leu Pro Ser Arg Leu Val Gln Arg Leu Gln Glu Val Ser Leu Arg 
        515                 520                 525             


Gln Gly Met Arg Ala Asp Pro Gly Val Leu Ala Ala Leu Cys Glu Lys 
    530                 535                 540                 


Thr Asp Asn Asp Ile Arg Ala Cys Ile Asn Thr Leu Gln Phe Leu Tyr 
545                 550                 555                 560 


Ser Arg Gly Gln Arg Glu Leu Ser Val Arg Asp Val Gln Ala Thr Arg 
                565                 570                 575     


Val Gly Leu Lys Asp Gln Arg Arg Gly Leu Phe Ser Val Trp Gln Glu 
            580                 585                 590         


Val Phe Gln Leu Pro Arg Ala Gln Arg Arg Arg Val Gly Gln Asp Pro 
        595                 600                 605             


Ala Leu Pro Ala Asp Thr Leu Leu Leu Gly Asp Gly Asp Ala Gly Ser 
    610                 615                 620                 


Leu Thr Ser Ala Ser Gln Arg Phe Tyr Arg Val Leu His Ala Ala Ala 
625                 630                 635                 640 


Ser Ala Gly Glu His Glu Lys Val Val Gln Gly Leu Phe Asp Asn Phe 
                645                 650                 655     


Leu Arg Leu Arg Leu Arg Asp Ser Ser Leu Gly Ala Val Cys Val Ala 
            660                 665                 670         


Leu Asp Trp Leu Ala Phe Asp Asp Leu Leu Ala Gly Ala Ala His His 
        675                 680                 685             


Ser Gln Ser Phe Gln Leu Leu Arg Tyr Pro Pro Phe Leu Pro Val Ala 
    690                 695                 700                 


Phe His Val Leu Phe Ala Ser Ser His Thr Pro Arg Ile Thr Phe Pro 
705                 710                 715                 720 


Ser Ser Gln Gln Glu Ala Gln Asn Arg Met Ser Gln Met Arg Asn Leu 
                725                 730                 735     


Ile Gln Thr Leu Val Ser Gly Ile Ala Pro Ala Thr Arg Ser Arg Ala 
            740                 745                 750         


Thr Pro Gln Ala Leu Leu Leu Asp Ala Leu Cys Leu Leu Leu Asp Ile 
        755                 760                 765             


Leu Ala Pro Lys Leu Arg Pro Val Ser Thr Gln Leu Tyr Ser Thr Arg 
    770                 775                 780                 


Glu Lys Gln Gln Leu Ala Ser Leu Val Gly Thr Met Leu Ala Tyr Ser 
785                 790                 795                 800 


Leu Thr Tyr Arg Gln Glu Arg Thr Pro Asp Gly Gln Tyr Ile Tyr Arg 
                805                 810                 815     


Leu Glu Pro Asn Val Glu Glu Leu Cys Arg Phe Pro Glu Leu Pro Ala 
            820                 825                 830         


Arg Lys Pro Leu Thr Tyr Gln Thr Lys Gln Leu Ile Ala Arg Glu Ile 
        835                 840                 845             


Glu Val Glu Lys Met Arg Arg Ala Glu Ala Ser Ala Arg Val Glu Asn 
    850                 855                 860                 


Ser Pro Gln Val Asp Gly Ser Pro Pro Gly Leu Glu Gly Leu Leu Gly 
865                 870                 875                 880 


Gly Ile Gly Glu Lys Gly Val His Arg Pro Ala Pro Arg Asn His Glu 
                885                 890                 895     


Gln Arg Leu Glu His Ile Met Arg Arg Ala Ala Arg Glu Glu Gln Pro 
            900                 905                 910         


Glu Lys Asp Phe Phe Gly Arg Val Val Val Arg Ser Thr Ala Val Pro 
        915                 920                 925             


Ser Ala Gly Asp Thr Ala Pro Glu Gln Asp Ser Val Glu Arg Arg Met 
    930                 935                 940                 


Gly Thr Ala Val Gly Arg Ser Glu Val Trp Phe Arg Phe Asn Glu Gly 
945                 950                 955                 960 


Val Ser Asn Ala Val Arg Arg Ser Leu Tyr Ile Arg Asp Leu Leu 
                965                 970                 975 


<210>  2191
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHTOP__Homo_sapiens__NP_001193541

<400>  2191

Met Ala Ala Gln Ser Ala Pro Lys Val Val Leu Lys Ser Thr Thr Lys 
1               5                   10                  15      


Met Ser Leu Asn Glu Arg Phe Thr Asn Met Leu Lys Asn Lys Gln Pro 
            20                  25                  30          


Thr Pro Val Asn Ile Arg Ala Ser Met Gln Gln Gln Gln Gln Leu Ala 
        35                  40                  45              


Ser Ala Arg Asn Arg Arg Leu Ala Gln Gln Met Glu Asn Arg Pro Ser 
    50                  55                  60                  


Val Gln Ala Ala Leu Lys Leu Lys Gln Lys Ser Leu Lys Gln Arg Leu 
65                  70                  75                  80  


Gly Lys Ser Asn Ile Gln Ala Arg Leu Gly Arg Pro Ile Gly Ala Leu 
                85                  90                  95      


Ala Arg Gly Ala Ile Gly Gly Arg Gly Leu Pro Ile Ile Gln Arg Gly 
            100                 105                 110         


Leu Pro Arg Gly Gly Leu Arg Gly Gly Arg Ala Thr Arg Thr Leu Leu 
        115                 120                 125             


Arg Gly Gly Met Ser Leu Arg Gly Gln Asn Leu Leu Arg Gly Gly Arg 
    130                 135                 140                 


Ala Val Ala Pro Arg Met Gly Leu Arg Arg Gly Gly Val Arg Gly Arg 
145                 150                 155                 160 


Gly Gly Pro Gly Arg Gly Gly Leu Gly Arg Gly Ala Met Gly Arg Gly 
                165                 170                 175     


Gly Ile Gly Gly Arg Gly Arg Gly Met Ile Gly Arg Gly Arg Gly Gly 
            180                 185                 190         


Phe Gly Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Ala Leu Ala 
        195                 200                 205             


Arg Pro Val Leu Thr Lys Glu Gln Leu Asp Asn Gln Leu Asp Ala Tyr 
    210                 215                 220                 


Met Ser Lys Thr Lys Gly His Leu Asp Ala Glu Leu Asp Ala Tyr Met 
225                 230                 235                 240 


Ala Gln Thr Asp Pro Glu Thr Asn Asp 
                245                 


<210>  2192
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHURC1__Homo_sapiens__NP_001190992

<400>  2192

Met Arg Gln Pro Tyr Leu Ser Ser Arg Glu Val Ser Ser Ser Arg Lys 
1               5                   10                  15      


Arg Trp Arg Thr Phe Pro Val Asp Cys Val Ala Met Cys Gly Asp Cys 
            20                  25                  30          


Val Glu Lys Glu Tyr Pro Asn Arg Gly Asn Thr Cys Leu Glu Asn Gly 
        35                  40                  45              


Ser Phe Leu Leu Asn Phe Thr Gly Cys Ala Val Cys Ser Lys Arg Asp 
    50                  55                  60                  


Phe Met Leu Ile Thr Asn Lys Ser Leu Lys Glu Glu Asp Gly Glu Glu 
65                  70                  75                  80  


Ile Val Thr Tyr Asp His Leu Cys Lys Asn Cys His His Val Ile Ala 
                85                  90                  95      


Arg His Glu Tyr Thr Phe Ser Ile Met Asp Glu Phe Gln Glu Tyr Thr 
            100                 105                 110         


Met Leu Cys Leu Leu Cys Gly Lys Ala Glu Asp Thr Ile Ser Ile Leu 
        115                 120                 125             


Pro Asp Asp Pro Arg Gln Met Thr Leu Leu Phe 
    130                 135                 


<210>  2193
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIAO1__Homo_sapiens__NP_004795

<400>  2193

Met Lys Asp Ser Leu Val Leu Leu Gly Arg Val Pro Ala His Pro Asp 
1               5                   10                  15      


Ser Arg Cys Trp Phe Leu Ala Trp Asn Pro Ala Gly Thr Leu Leu Ala 
            20                  25                  30          


Ser Cys Gly Gly Asp Arg Arg Ile Arg Ile Trp Gly Thr Glu Gly Asp 
        35                  40                  45              


Ser Trp Ile Cys Lys Ser Val Leu Ser Glu Gly His Gln Arg Thr Val 
    50                  55                  60                  


Arg Lys Val Ala Trp Ser Pro Cys Gly Asn Tyr Leu Ala Ser Ala Ser 
65                  70                  75                  80  


Phe Asp Ala Thr Thr Cys Ile Trp Lys Lys Asn Gln Asp Asp Phe Glu 
                85                  90                  95      


Cys Val Thr Thr Leu Glu Gly His Glu Asn Glu Val Lys Ser Val Ala 
            100                 105                 110         


Trp Ala Pro Ser Gly Asn Leu Leu Ala Thr Cys Ser Arg Asp Lys Ser 
        115                 120                 125             


Val Trp Val Trp Glu Val Asp Glu Glu Asp Glu Tyr Glu Cys Val Ser 
    130                 135                 140                 


Val Leu Asn Ser His Thr Gln Asp Val Lys His Val Val Trp His Pro 
145                 150                 155                 160 


Ser Gln Glu Leu Leu Ala Ser Ala Ser Tyr Asp Asp Thr Val Lys Leu 
                165                 170                 175     


Tyr Arg Glu Glu Glu Asp Asp Trp Val Cys Cys Ala Thr Leu Glu Gly 
            180                 185                 190         


His Glu Ser Thr Val Trp Ser Leu Ala Phe Asp Pro Ser Gly Gln Arg 
        195                 200                 205             


Leu Ala Ser Cys Ser Asp Asp Arg Thr Val Arg Ile Trp Arg Gln Tyr 
    210                 215                 220                 


Leu Pro Gly Asn Glu Gln Gly Val Ala Cys Ser Gly Ser Asp Pro Ser 
225                 230                 235                 240 


Trp Lys Cys Ile Cys Thr Leu Ser Gly Phe His Ser Arg Thr Ile Tyr 
                245                 250                 255     


Asp Ile Ala Trp Cys Gln Leu Thr Gly Ala Leu Ala Thr Ala Cys Gly 
            260                 265                 270         


Asp Asp Ala Ile Arg Val Phe Gln Glu Asp Pro Asn Ser Asp Pro Gln 
        275                 280                 285             


Gln Pro Thr Phe Ser Leu Thr Ala His Leu His Gln Ala His Ser Gln 
    290                 295                 300                 


Asp Val Asn Cys Val Ala Trp Asn Pro Lys Glu Pro Gly Leu Leu Ala 
305                 310                 315                 320 


Ser Cys Ser Asp Asp Gly Glu Val Ala Phe Trp Lys Tyr Gln Arg Pro 
                325                 330                 335     


Glu Gly Leu 
            


<210>  2194
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIAPIN1__Homo_sapiens__NP_064709

<400>  2194

Met Ala Asp Phe Gly Ile Ser Ala Gly Gln Phe Val Ala Val Val Trp 
1               5                   10                  15      


Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu 
            20                  25                  30          


Gln Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn Ile Lys 
        35                  40                  45              


Gln Leu Leu Gln Ser Ala His Lys Glu Ser Ser Phe Asp Ile Ile Leu 
    50                  55                  60                  


Ser Gly Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala Glu Ile Leu 
65                  70                  75                  80  


Ala Glu Ile Ala Arg Ile Leu Arg Pro Gly Gly Cys Leu Phe Leu Lys 
                85                  90                  95      


Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val Lys Thr Ala 
            100                 105                 110         


Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val Glu Val Lys 
        115                 120                 125             


Glu Leu Gln Arg Glu Pro Leu Thr Pro Glu Glu Val Gln Ser Val Arg 
    130                 135                 140                 


Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val Gln Ile Thr 
145                 150                 155                 160 


Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gln Leu Lys Leu 
                165                 170                 175     


Ser Ile Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala Val Asp Pro 
            180                 185                 190         


Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met Glu Asp Asp 
        195                 200                 205             


Ser Met Asp Leu Ile Asp Ser Asp Glu Leu Leu Asp Pro Glu Asp Leu 
    210                 215                 220                 


Lys Lys Pro Asp Pro Ala Ser Leu Arg Ala Ala Ser Cys Gly Glu Gly 
225                 230                 235                 240 


Lys Lys Arg Lys Ala Cys Lys Asn Cys Thr Cys Gly Leu Ala Glu Glu 
                245                 250                 255     


Leu Glu Lys Glu Lys Ser Arg Glu Gln Met Ser Ser Gln Pro Lys Ser 
            260                 265                 270         


Ala Cys Gly Asn Cys Tyr Leu Gly Asp Ala Phe Arg Cys Ala Ser Cys 
        275                 280                 285             


Pro Tyr Leu Gly Met Pro Ala Phe Lys Pro Gly Glu Lys Val Leu Leu 
    290                 295                 300                 


Ser Asp Ser Asn Leu His Asp Ala 
305                 310         


<210>  2195
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIB1__Homo_sapiens__NP_006375

<400>  2195

Met Gly Gly Ser Gly Ser Arg Leu Ser Lys Glu Leu Leu Ala Glu Tyr 
1               5                   10                  15      


Gln Asp Leu Thr Phe Leu Thr Lys Gln Glu Ile Leu Leu Ala His Arg 
            20                  25                  30          


Arg Phe Cys Glu Leu Leu Pro Gln Glu Gln Arg Ser Val Glu Ser Ser 
        35                  40                  45              


Leu Arg Ala Gln Val Pro Phe Glu Gln Ile Leu Ser Leu Pro Glu Leu 
    50                  55                  60                  


Lys Ala Asn Pro Phe Lys Glu Arg Ile Cys Arg Val Phe Ser Thr Ser 
65                  70                  75                  80  


Pro Ala Lys Asp Ser Leu Ser Phe Glu Asp Phe Leu Asp Leu Leu Ser 
                85                  90                  95      


Val Phe Ser Asp Thr Ala Thr Pro Asp Ile Lys Ser His Tyr Ala Phe 
            100                 105                 110         


Arg Ile Phe Asp Phe Asp Asp Asp Gly Thr Leu Asn Arg Glu Asp Leu 
        115                 120                 125             


Ser Arg Leu Val Asn Cys Leu Thr Gly Glu Gly Glu Asp Thr Arg Leu 
    130                 135                 140                 


Ser Ala Ser Glu Met Lys Gln Leu Ile Asp Asn Ile Leu Glu Glu Ser 
145                 150                 155                 160 


Asp Ile Asp Arg Asp Gly Thr Ile Asn Leu Ser Glu Phe Gln His Val 
                165                 170                 175     


Ile Ser Arg Ser Pro Asp Phe Ala Ser Ser Phe Lys Ile Val Leu 
            180                 185                 190     


<210>  2196
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIB2__Homo_sapiens__NP_006374

<400>  2196

Met Gly Asn Lys Gln Thr Ile Phe Thr Glu Glu Gln Leu Asp Asn Tyr 
1               5                   10                  15      


Gln Asp Cys Thr Phe Phe Asn Lys Lys Asp Ile Leu Lys Leu His Ser 
            20                  25                  30          


Arg Phe Tyr Glu Leu Ala Pro Asn Leu Val Pro Met Asp Tyr Arg Lys 
        35                  40                  45              


Ser Pro Ile Val His Val Pro Met Ser Leu Ile Ile Gln Met Pro Glu 
    50                  55                  60                  


Leu Arg Glu Asn Pro Phe Lys Glu Arg Ile Val Ala Ala Phe Ser Glu 
65                  70                  75                  80  


Asp Gly Glu Gly Asn Leu Thr Phe Asn Asp Phe Val Asp Met Phe Ser 
                85                  90                  95      


Val Leu Cys Glu Ser Ala Pro Arg Glu Leu Lys Ala Asn Tyr Ala Phe 
            100                 105                 110         


Lys Ile Tyr Asp Phe Asn Thr Asp Asn Phe Ile Cys Lys Glu Asp Leu 
        115                 120                 125             


Glu Leu Thr Leu Ala Arg Leu Thr Lys Ser Glu Leu Asp Glu Glu Glu 
    130                 135                 140                 


Val Val Leu Val Cys Asp Lys Val Ile Glu Glu Ala Asp Leu Asp Gly 
145                 150                 155                 160 


Asp Gly Lys Leu Gly Phe Ala Asp Phe Glu Asp Met Ile Ala Lys Ala 
                165                 170                 175     


Pro Asp Phe Leu Ser Thr Phe His Ile Arg Ile 
            180                 185         


<210>  2197
<211>  1608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIC__Homo_sapiens__NP_055940

<400>  2197

Met Tyr Ser Ala His Arg Pro Leu Met Pro Ala Ser Ser Ala Ala Ser 
1               5                   10                  15      


Arg Gly Leu Gly Met Phe Val Trp Thr Asn Val Glu Pro Arg Ser Val 
            20                  25                  30          


Ala Val Phe Pro Trp His Ser Leu Val Pro Phe Leu Ala Pro Ser Gln 
        35                  40                  45              


Pro Asp Pro Ser Val Gln Pro Ser Glu Ala Gln Gln Pro Ala Ser His 
    50                  55                  60                  


Pro Val Ala Ser Asn Gln Ser Lys Glu Pro Ala Glu Ser Ala Ala Val 
65                  70                  75                  80  


Ala His Glu Arg Pro Pro Gly Gly Thr Gly Ser Ala Asp Pro Glu Arg 
                85                  90                  95      


Pro Pro Gly Ala Thr Cys Pro Glu Ser Pro Gly Pro Gly Pro Pro His 
            100                 105                 110         


Pro Leu Gly Val Val Glu Ser Gly Lys Gly Pro Pro Pro Thr Thr Glu 
        115                 120                 125             


Glu Glu Ala Ser Gly Pro Pro Gly Glu Pro Arg Leu Asp Ser Glu Thr 
    130                 135                 140                 


Glu Ser Asp His Asp Asp Ala Phe Leu Ser Ile Met Ser Pro Glu Ile 
145                 150                 155                 160 


Gln Leu Pro Leu Pro Pro Gly Lys Arg Arg Thr Gln Ser Leu Ser Ala 
                165                 170                 175     


Leu Pro Lys Glu Arg Asp Ser Ser Ser Glu Lys Asp Gly Arg Ser Pro 
            180                 185                 190         


Asn Lys Arg Glu Lys Asp His Ile Arg Arg Pro Met Asn Ala Phe Met 
        195                 200                 205             


Ile Phe Ser Lys Arg His Arg Ala Leu Val His Gln Arg His Pro Asn 
    210                 215                 220                 


Gln Asp Asn Arg Thr Val Ser Lys Ile Leu Gly Glu Trp Trp Tyr Ala 
225                 230                 235                 240 


Leu Gly Pro Lys Glu Lys Gln Lys Tyr His Asp Leu Ala Phe Gln Val 
                245                 250                 255     


Lys Glu Ala His Phe Lys Ala His Pro Asp Trp Lys Trp Cys Asn Lys 
            260                 265                 270         


Asp Arg Lys Lys Ser Ser Ser Glu Ala Lys Pro Thr Ser Leu Gly Leu 
        275                 280                 285             


Ala Gly Gly His Lys Glu Thr Arg Glu Arg Ser Met Ser Glu Thr Gly 
    290                 295                 300                 


Thr Ala Ala Ala Pro Gly Val Ser Ser Glu Leu Leu Ser Val Ala Ala 
305                 310                 315                 320 


Gln Thr Leu Leu Ser Ser Asp Thr Lys Ala Pro Gly Ser Ser Ser Cys 
                325                 330                 335     


Gly Ala Glu Arg Leu His Thr Val Gly Gly Pro Gly Ser Ala Arg Pro 
            340                 345                 350         


Arg Ala Phe Ser His Ser Gly Val His Ser Leu Asp Gly Gly Glu Val 
        355                 360                 365             


Asp Ser Gln Ala Leu Gln Glu Leu Thr Gln Met Val Ser Gly Pro Ala 
    370                 375                 380                 


Ser Tyr Ser Gly Pro Lys Pro Ser Thr Gln Tyr Gly Ala Pro Gly Pro 
385                 390                 395                 400 


Phe Ala Ala Pro Gly Glu Gly Gly Ala Leu Ala Ala Thr Gly Arg Pro 
                405                 410                 415     


Pro Leu Leu Pro Thr Arg Ala Ser Arg Ser Gln Arg Ala Ala Ser Glu 
            420                 425                 430         


Asp Met Thr Ser Asp Glu Glu Arg Met Val Ile Cys Glu Glu Glu Gly 
        435                 440                 445             


Asp Asp Asp Val Ile Ala Asp Asp Gly Phe Gly Thr Thr Asp Ile Asp 
    450                 455                 460                 


Leu Lys Cys Lys Glu Arg Val Thr Asp Ser Glu Ser Gly Asp Ser Ser 
465                 470                 475                 480 


Gly Glu Asp Pro Glu Gly Asn Lys Gly Phe Gly Arg Lys Val Phe Ser 
                485                 490                 495     


Pro Val Ile Arg Ser Ser Phe Thr His Cys Arg Pro Pro Leu Asp Pro 
            500                 505                 510         


Glu Pro Pro Gly Pro Pro Asp Pro Pro Val Ala Phe Gly Lys Gly Tyr 
        515                 520                 525             


Gly Ser Ala Pro Ser Ser Ser Ala Ser Ser Pro Ala Ser Ser Ser Ala 
    530                 535                 540                 


Ser Ala Ala Thr Ser Phe Ser Leu Gly Ser Gly Thr Phe Lys Ala Gln 
545                 550                 555                 560 


Glu Ser Gly Gln Gly Ser Thr Ala Gly Pro Leu Arg Pro Pro Pro Pro 
                565                 570                 575     


Gly Ala Gly Gly Pro Ala Thr Pro Ser Lys Ala Thr Arg Phe Leu Pro 
            580                 585                 590         


Met Asp Pro Ala Thr Phe Arg Arg Lys Arg Pro Glu Ser Val Gly Gly 
        595                 600                 605             


Leu Glu Pro Pro Gly Pro Ser Val Ile Ala Ala Pro Pro Ser Gly Gly 
    610                 615                 620                 


Gly Asn Ile Leu Gln Thr Leu Val Leu Pro Pro Asn Lys Glu Glu Gln 
625                 630                 635                 640 


Glu Gly Gly Gly Ala Arg Val Pro Ser Ala Pro Ala Pro Ser Leu Ala 
                645                 650                 655     


Tyr Gly Ala Pro Ala Ala Pro Leu Ser Arg Pro Ala Ala Thr Met Val 
            660                 665                 670         


Thr Asn Val Val Arg Pro Val Ser Ser Thr Pro Val Pro Ile Ala Ser 
        675                 680                 685             


Lys Pro Phe Pro Thr Ser Gly Arg Ala Glu Ala Ser Pro Asn Asp Thr 
    690                 695                 700                 


Ala Gly Ala Arg Thr Glu Met Gly Thr Gly Ser Arg Val Pro Gly Gly 
705                 710                 715                 720 


Ser Pro Leu Gly Val Ser Leu Val Tyr Ser Asp Lys Lys Ser Ala Ala 
                725                 730                 735     


Ala Thr Ser Pro Ala Pro His Leu Val Ala Gly Pro Leu Leu Gly Thr 
            740                 745                 750         


Val Gly Lys Ala Pro Ala Thr Val Thr Asn Leu Leu Val Gly Thr Pro 
        755                 760                 765             


Gly Tyr Gly Ala Pro Ala Pro Pro Ala Val Gln Phe Ile Ala Gln Gly 
    770                 775                 780                 


Ala Pro Gly Gly Gly Thr Thr Ala Gly Ser Gly Ala Gly Ala Gly Ser 
785                 790                 795                 800 


Gly Pro Asn Gly Pro Val Pro Leu Gly Ile Leu Gln Pro Gly Ala Leu 
                805                 810                 815     


Gly Lys Ala Gly Gly Ile Thr Gln Val Gln Tyr Ile Leu Pro Thr Leu 
            820                 825                 830         


Pro Gln Gln Leu Gln Val Ala Pro Ala Pro Ala Pro Ala Pro Gly Thr 
        835                 840                 845             


Lys Ala Ala Ala Pro Ser Gly Pro Ala Pro Thr Thr Ser Ile Arg Phe 
    850                 855                 860                 


Thr Leu Pro Pro Gly Thr Ser Thr Asn Gly Lys Val Leu Ala Ala Thr 
865                 870                 875                 880 


Ala Pro Thr Pro Gly Ile Pro Ile Leu Gln Ser Val Pro Ser Ala Pro 
                885                 890                 895     


Pro Pro Lys Ala Gln Ser Val Ser Pro Val Gln Ala Pro Pro Pro Gly 
            900                 905                 910         


Gly Ser Ala Gln Leu Leu Pro Gly Lys Val Leu Val Pro Leu Ala Ala 
        915                 920                 925             


Pro Ser Met Ser Val Arg Gly Gly Gly Ala Gly Gln Pro Leu Pro Leu 
    930                 935                 940                 


Val Ser Pro Pro Phe Ser Val Pro Val Gln Asn Gly Ala Gln Pro Pro 
945                 950                 955                 960 


Ser Lys Ile Ile Gln Leu Thr Pro Val Pro Val Ser Thr Pro Ser Gly 
                965                 970                 975     


Leu Val Pro Pro Leu Ser Pro Ala Thr Leu Pro Gly Pro Thr Ser Gln 
            980                 985                 990         


Pro Gln Lys Val Leu Leu Pro Ser  Ser Thr Arg Ile Thr  Tyr Val Gln 
        995                 1000                 1005             


Ser Ala  Gly Gly His Ala Leu  Pro Leu Gly Thr Ser  Pro Ala Ser 
    1010                 1015                 1020             


Ser Gln  Ala Gly Thr Val Thr  Ser Tyr Gly Pro Thr  Ser Ser Val 
    1025                 1030                 1035             


Ala Leu  Gly Phe Thr Ser Leu  Gly Pro Ser Gly Pro  Ala Phe Val 
    1040                 1045                 1050             


Gln Pro  Leu Leu Ser Ala Gly  Gln Ala Pro Leu Leu  Ala Pro Gly 
    1055                 1060                 1065             


Gln Val  Gly Val Ser Pro Val  Pro Ser Pro Gln Leu  Pro Pro Ala 
    1070                 1075                 1080             


Cys Ala  Ala Pro Gly Gly Pro  Val Ile Thr Ala Phe  Tyr Ser Gly 
    1085                 1090                 1095             


Ser Pro  Ala Pro Thr Ser Ser  Ala Pro Leu Ala Gln  Pro Ser Gln 
    1100                 1105                 1110             


Ala Pro  Pro Ser Leu Val Tyr  Thr Val Ala Thr Ser  Thr Thr Pro 
    1115                 1120                 1125             


Pro Ala  Ala Thr Ile Leu Pro  Lys Gly Pro Pro Ala  Pro Ala Thr 
    1130                 1135                 1140             


Ala Thr  Pro Ala Pro Thr Ser  Pro Phe Pro Ser Ala  Thr Ala Gly 
    1145                 1150                 1155             


Ser Met  Thr Tyr Ser Leu Val  Ala Pro Lys Ala Gln  Arg Pro Ser 
    1160                 1165                 1170             


Pro Lys  Ala Pro Gln Lys Val  Lys Ala Ala Ile Ala  Ser Ile Pro 
    1175                 1180                 1185             


Val Gly  Ser Phe Glu Ala Gly  Ala Ser Gly Arg Pro  Gly Pro Ala 
    1190                 1195                 1200             


Pro Arg  Gln Pro Leu Glu Pro  Gly Pro Val Arg Glu  Pro Thr Ala 
    1205                 1210                 1215             


Pro Glu  Ser Glu Leu Glu Gly  Gln Pro Thr Pro Pro  Ala Pro Pro 
    1220                 1225                 1230             


Pro Leu  Pro Glu Thr Trp Thr  Pro Thr Ala Arg Ser  Ser Pro Pro 
    1235                 1240                 1245             


Leu Pro  Pro Pro Ala Glu Glu  Arg Thr Ser Ala Lys  Gly Pro Glu 
    1250                 1255                 1260             


Thr Met  Ala Ser Lys Phe Pro  Ser Ser Ser Ser Asp  Trp Arg Val 
    1265                 1270                 1275             


Pro Gly  Gln Gly Leu Glu Asn  Arg Gly Glu Pro Pro  Thr Pro Pro 
    1280                 1285                 1290             


Ser Pro  Ala Pro Ala Pro Ala  Val Ala Pro Gly Gly  Ser Ser Glu 
    1295                 1300                 1305             


Ser Ser  Ser Gly Arg Ala Ala  Gly Asp Thr Pro Glu  Arg Lys Glu 
    1310                 1315                 1320             


Ala Ala  Gly Thr Gly Lys Lys  Val Lys Val Arg Pro  Pro Pro Leu 
    1325                 1330                 1335             


Lys Lys  Thr Phe Asp Ser Val  Asp Asn Arg Val Leu  Ser Glu Val 
    1340                 1345                 1350             


Asp Phe  Glu Glu Arg Phe Ala  Glu Leu Pro Glu Phe  Arg Pro Glu 
    1355                 1360                 1365             


Glu Val  Leu Pro Ser Pro Thr  Leu Gln Ser Leu Ala  Thr Ser Pro 
    1370                 1375                 1380             


Arg Ala  Ile Leu Gly Ser Tyr  Arg Lys Lys Arg Lys  Asn Ser Thr 
    1385                 1390                 1395             


Asp Leu  Asp Ser Ala Pro Glu  Asp Pro Thr Ser Pro  Lys Arg Lys 
    1400                 1405                 1410             


Met Arg  Arg Arg Ser Ser Cys  Ser Ser Glu Pro Asn  Thr Pro Lys 
    1415                 1420                 1425             


Ser Ala  Lys Cys Glu Gly Asp  Ile Phe Thr Phe Asp  Arg Thr Gly 
    1430                 1435                 1440             


Thr Glu  Ala Glu Asp Val Leu  Gly Glu Leu Glu Tyr  Asp Lys Val 
    1445                 1450                 1455             


Pro Tyr  Ser Ser Leu Arg Arg  Thr Leu Asp Gln Arg  Arg Ala Leu 
    1460                 1465                 1470             


Val Met  Gln Leu Phe Gln Asp  His Gly Phe Phe Pro  Ser Ala Gln 
    1475                 1480                 1485             


Ala Thr  Ala Ala Phe Gln Ala  Arg Tyr Ala Asp Ile  Phe Pro Ser 
    1490                 1495                 1500             


Lys Val  Cys Leu Gln Leu Lys  Ile Arg Glu Val Arg  Gln Lys Ile 
    1505                 1510                 1515             


Met Gln  Ala Ala Thr Pro Thr  Glu Gln Pro Pro Gly  Ala Glu Ala 
    1520                 1525                 1530             


Pro Leu  Pro Val Pro Pro Pro  Thr Gly Thr Ala Ala  Ala Pro Ala 
    1535                 1540                 1545             


Pro Thr  Pro Ser Pro Ala Gly  Gly Pro Asp Pro Thr  Ser Pro Ser 
    1550                 1555                 1560             


Ser Asp  Ser Gly Thr Ala Gln  Ala Ala Pro Pro Leu  Pro Pro Pro 
    1565                 1570                 1575             


Pro Glu  Ser Gly Pro Gly Gln  Pro Gly Trp Glu Gly  Ala Pro Gln 
    1580                 1585                 1590             


Pro Ser  Pro Pro Pro Pro Gly  Pro Ser Thr Ala Ala  Thr Gly Arg 
    1595                 1600                 1605             


<210>  2198
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIDEB__Homo_sapiens__NP_001305736

<400>  2198

Met Glu Tyr Leu Ser Ala Leu Asn Pro Ser Asp Leu Leu Arg Ser Val 
1               5                   10                  15      


Ser Asn Ile Ser Ser Glu Phe Gly Arg Arg Val Trp Thr Ser Ala Pro 
            20                  25                  30          


Pro Pro Gln Arg Pro Phe Arg Val Cys Asp His Lys Arg Thr Ile Arg 
        35                  40                  45              


Lys Gly Leu Thr Ala Ala Thr Arg Gln Glu Leu Leu Ala Lys Ala Leu 
    50                  55                  60                  


Glu Thr Leu Leu Leu Asn Gly Val Leu Thr Leu Val Leu Glu Glu Asp 
65                  70                  75                  80  


Gly Thr Ala Val Asp Ser Glu Asp Phe Phe Gln Leu Leu Glu Asp Asp 
                85                  90                  95      


Thr Cys Leu Met Val Leu Gln Ser Gly Gln Ser Trp Ser Pro Thr Arg 
            100                 105                 110         


Ser Gly Val Leu Ser Tyr Gly Leu Gly Arg Glu Arg Pro Lys His Ser 
        115                 120                 125             


Lys Asp Ile Ala Arg Phe Thr Phe Asp Val Tyr Lys Gln Asn Pro Arg 
    130                 135                 140                 


Asp Leu Phe Gly Ser Leu Asn Val Lys Ala Thr Phe Tyr Gly Leu Tyr 
145                 150                 155                 160 


Ser Met Ser Cys Asp Phe Gln Gly Leu Gly Pro Lys Lys Val Leu Arg 
                165                 170                 175     


Glu Leu Leu Arg Trp Thr Ser Thr Leu Leu Gln Gly Leu Gly His Met 
            180                 185                 190         


Leu Leu Gly Ile Ser Ser Thr Leu Arg His Ala Val Glu Gly Ala Glu 
        195                 200                 205             


Gln Trp Gln Gln Lys Gly Arg Leu His Ser Tyr 
    210                 215                 


<210>  2199
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIDEC__Homo_sapiens__NP_001186480

<400>  2199

Met Glu Tyr Ala Met Lys Ser Leu Ser Leu Leu Tyr Pro Lys Ser Leu 
1               5                   10                  15      


Ser Arg His Val Ser Val Arg Thr Ser Val Val Thr Gln Gln Leu Leu 
            20                  25                  30          


Ser Glu Pro Ser Pro Lys Ala Pro Arg Ala Arg Pro Cys Arg Val Ser 
        35                  40                  45              


Thr Ala Asp Arg Ser Val Arg Lys Gly Ile Met Ala Tyr Ser Leu Glu 
    50                  55                  60                  


Asp Leu Leu Leu Lys Thr Arg Asn Pro Glu Ala Arg Ser Gln Glu Val 
65                  70                  75                  80  


Arg Asp Thr Leu Met Leu Ala Asp Lys Pro Phe Phe Leu Val Leu Glu 
                85                  90                  95      


Glu Asp Gly Thr Thr Val Glu Thr Glu Glu Tyr Phe Gln Ala Leu Ala 
            100                 105                 110         


Gly Asp Thr Val Phe Met Val Leu Gln Lys Gly Gln Lys Trp Gln Pro 
        115                 120                 125             


Pro Ser Glu Gln Gly Thr Arg His Pro Leu Ser Leu Ser His Lys Pro 
    130                 135                 140                 


Ala Lys Lys Ile Asp Val Ala Arg Val Thr Phe Asp Leu Tyr Lys Leu 
145                 150                 155                 160 


Asn Pro Gln Asp Phe Ile Gly Cys Leu Asn Val Lys Ala Thr Phe Tyr 
                165                 170                 175     


Asp Thr Tyr Ser Leu Ser Tyr Asp Leu His Cys Cys Gly Ala Lys Arg 
            180                 185                 190         


Ile Met Lys Glu Ala Phe Arg Trp Ala Leu Phe Ser Met Gln Ala Thr 
        195                 200                 205             


Gly His Val Leu Leu Gly Thr Ser Cys Tyr Leu Gln Gln Leu Leu Asp 
    210                 215                 220                 


Ala Thr Glu Glu Gly Gln Pro Pro Lys Gly Lys Ala Ser Ser Leu Ile 
225                 230                 235                 240 


Pro Thr Cys Leu Lys Ile Leu Gln 
                245             


<210>  2200
<211>  1130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIITA__Homo_sapiens__NP_000237

<400>  2200

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Lys His Ile Gly Pro Asp Glu Val Ile 
        115                 120                 125             


Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln Lys 
    130                 135                 140                 


Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys Pro 
145                 150                 155                 160 


Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Gly Pro Val 
                165                 170                 175     


Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe Asn 
            180                 185                 190         


Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln Ile 
        195                 200                 205             


Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro Glu 
    210                 215                 220                 


Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly Leu 
225                 230                 235                 240 


Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile Tyr 
                245                 250                 255     


His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly Phe 
            260                 265                 270         


Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr Ser 
        275                 280                 285             


Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro Ala 
    290                 295                 300                 


Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr Gln 
305                 310                 315                 320 


Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro Glu 
                325                 330                 335     


Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala Glu 
            340                 345                 350         


Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln Ala 
        355                 360                 365             


Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala Thr 
    370                 375                 380                 


Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu Val 
385                 390                 395                 400 


Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val Ile 
                405                 410                 415     


Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly Ala 
            420                 425                 430         


Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe Val 
        435                 440                 445             


Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr Gly 
    450                 455                 460                 


Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala Ala 
465                 470                 475                 480 


Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu Leu 
                485                 490                 495     


Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu His 
            500                 505                 510         


Ser Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly Leu 
        515                 520                 525             


Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu Leu 
    530                 535                 540                 


Leu Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln Ala 
                565                 570                 575     


Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln Asp 
            580                 585                 590         


Arg Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His Ser 
        595                 600                 605             


His Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala Leu 
    610                 615                 620                 


Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly Leu 
625                 630                 635                 640 


Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly Ala 
                645                 650                 655     


Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His Gln 
            660                 665                 670         


Ser Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr Trp 
        675                 680                 685             


Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu Ser 
    690                 695                 700                 


Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala Leu 
705                 710                 715                 720 


Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln Tyr 
                725                 730                 735     


Leu Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu Glu 
            740                 745                 750         


Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala Arg 
        755                 760                 765             


Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp Arg 
    770                 775                 780                 


Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly Thr 
785                 790                 795                 800 


Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu Ala 
                805                 810                 815     


Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly Arg 
            820                 825                 830         


Leu Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val Leu 
        835                 840                 845             


Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu Arg 
    850                 855                 860                 


Ser Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu Ser 
865                 870                 875                 880 


Cys Val Thr Arg Phe Arg Ala Ala Leu Ser Asp Thr Val Ala Leu Trp 
                885                 890                 895     


Glu Ser Leu Gln Gln His Gly Glu Thr Lys Leu Leu Gln Ala Ala Glu 
            900                 905                 910         


Glu Lys Phe Thr Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp Val 
        915                 920                 925             


Glu Asp Leu Gly Lys Leu Val Gln Thr Gln Arg Thr Arg Ser Ser Ser 
    930                 935                 940                 


Glu Asp Thr Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys Leu 
945                 950                 955                 960 


Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys Leu 
                965                 970                 975     


Val Arg Ile Leu Thr Ala Phe Ser Ser Leu Gln His Leu Asp Leu Asp 
            980                 985                 990         


Ala Leu Ser Glu Asn Lys Ile Gly  Asp Glu Gly Val Ser  Gln Leu Ser 
        995                 1000                 1005             


Ala Thr  Phe Pro Gln Leu Lys  Ser Leu Glu Thr Leu  Asn Leu Ser 
    1010                 1015                 1020             


Gln Asn  Asn Ile Thr Asp Leu  Gly Ala Tyr Lys Leu  Ala Glu Ala 
    1025                 1030                 1035             


Leu Pro  Ser Leu Ala Ala Ser  Leu Leu Arg Leu Ser  Leu Tyr Asn 
    1040                 1045                 1050             


Asn Cys  Ile Cys Asp Val Gly  Ala Glu Ser Leu Ala  Arg Val Leu 
    1055                 1060                 1065             


Pro Asp  Met Val Ser Leu Arg  Val Met Asp Val Gln  Tyr Asn Lys 
    1070                 1075                 1080             


Phe Thr  Ala Ala Gly Ala Gln  Gln Leu Ala Ala Ser  Leu Arg Arg 
    1085                 1090                 1095             


Cys Pro  His Val Glu Thr Leu  Ala Met Trp Thr Pro  Thr Ile Pro 
    1100                 1105                 1110             


Phe Ser  Val Gln Glu His Leu  Gln Gln Gln Asp Ser  Arg Ile Ser 
    1115                 1120                 1125             


Leu Arg  
    1130 


<210>  2201
<211>  1156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CILP2__Homo_sapiens__NP_694953

<400>  2201

Met Ala Ser Leu Leu Pro Leu Leu Cys Leu Cys Val Val Ala Ala His 
1               5                   10                  15      


Leu Ala Gly Ala Arg Asp Ala Thr Pro Thr Glu Glu Pro Met Ala Thr 
            20                  25                  30          


Ala Leu Gly Leu Glu Arg Arg Ser Val Tyr Thr Gly Gln Pro Ser Pro 
        35                  40                  45              


Ala Leu Glu Asp Trp Glu Glu Ala Ser Glu Trp Thr Ser Trp Phe Asn 
    50                  55                  60                  


Val Asp His Pro Gly Gly Asp Gly Asp Phe Glu Ser Leu Ala Ala Ile 
65                  70                  75                  80  


Arg Phe Tyr Tyr Gly Pro Ala Arg Val Cys Pro Arg Pro Leu Ala Leu 
                85                  90                  95      


Glu Ala Arg Thr Thr Asp Trp Ala Leu Pro Ser Ala Val Gly Glu Arg 
            100                 105                 110         


Val His Leu Asn Pro Thr Arg Gly Phe Trp Cys Leu Asn Arg Glu Gln 
        115                 120                 125             


Pro Arg Gly Arg Arg Cys Ser Asn Tyr His Val Arg Phe Arg Cys Pro 
    130                 135                 140                 


Leu Glu Ala Ser Trp Gly Ala Trp Gly Pro Trp Gly Pro Cys Ser Gly 
145                 150                 155                 160 


Ser Cys Gly Pro Gly Arg Arg Leu Arg Arg Arg His Cys Pro Ser Pro 
                165                 170                 175     


Ala Gly Asp Ala Cys Pro Gly Arg Pro Leu Glu Ala Gln Lys Cys Val 
            180                 185                 190         


Arg Pro Arg Cys Pro Gly Cys Ser Leu Asp Thr Cys Glu Cys Pro Asp 
        195                 200                 205             


His Ile Leu Leu Gly Ser Val Val Thr Pro Ser Gly Gln Pro Leu Leu 
    210                 215                 220                 


Gly Ala Arg Val Ser Leu Arg Asp Gln Pro Gly Thr Val Ala Thr Ser 
225                 230                 235                 240 


Asp Ala His Gly Thr Phe Arg Val Pro Gly Val Cys Ala Asp Ser Arg 
                245                 250                 255     


Ala Asn Ile Arg Ala Gln Met Asp Gly Phe Ser Ala Gly Glu Ala Gln 
            260                 265                 270         


Ala Gln Ala Asn Gly Ser Ile Ser Val Val Thr Ile Ile Leu Asp Lys 
        275                 280                 285             


Leu Glu Lys Pro Tyr Leu Val Lys His Pro Glu Ser Arg Val Arg Glu 
    290                 295                 300                 


Ala Gly Gln Asn Val Thr Phe Cys Cys Lys Ala Ser Gly Thr Pro Met 
305                 310                 315                 320 


Pro Lys Lys Tyr Ser Trp Phe His Asn Gly Thr Leu Leu Asp Arg Arg 
                325                 330                 335     


Ala His Gly Tyr Gly Ala His Leu Glu Leu Arg Gly Leu Arg Pro Asp 
            340                 345                 350         


Gln Ala Gly Ile Tyr His Cys Lys Ala Trp Asn Glu Ala Gly Ala Val 
        355                 360                 365             


Arg Ser Gly Thr Ala Arg Leu Thr Val Leu Ala Pro Gly Gln Pro Ala 
    370                 375                 380                 


Cys Asp Pro Arg Pro Arg Glu Tyr Leu Ile Lys Leu Pro Glu Asp Cys 
385                 390                 395                 400 


Gly Gln Pro Gly Ser Gly Pro Ala Tyr Leu Asp Val Gly Leu Cys Pro 
                405                 410                 415     


Asp Thr Arg Cys Pro Ser Leu Ala Gly Ser Ser Pro Arg Cys Gly Asp 
            420                 425                 430         


Ala Ser Ser Arg Cys Cys Ser Val Arg Arg Leu Glu Arg Arg Glu Ile 
        435                 440                 445             


His Cys Pro Gly Tyr Val Leu Pro Val Lys Val Val Ala Glu Cys Gly 
    450                 455                 460                 


Cys Gln Lys Cys Leu Pro Pro Arg Gly Leu Val Arg Gly Arg Val Val 
465                 470                 475                 480 


Ala Ala Asp Ser Gly Glu Pro Leu Arg Phe Ala Arg Ile Leu Leu Gly 
                485                 490                 495     


Gln Glu Pro Ile Gly Phe Thr Ala Tyr Gln Gly Asp Phe Thr Ile Glu 
            500                 505                 510         


Val Pro Pro Ser Thr Gln Arg Leu Val Val Thr Phe Val Asp Pro Ser 
        515                 520                 525             


Gly Glu Phe Met Asp Ala Val Arg Val Leu Pro Phe Asp Pro Arg Gly 
    530                 535                 540                 


Ala Gly Val Tyr His Glu Val Lys Ala Met Arg Lys Lys Ala Pro Val 
545                 550                 555                 560 


Ile Leu His Thr Ser Gln Ser Asn Thr Ile Pro Leu Gly Glu Leu Glu 
                565                 570                 575     


Asp Glu Ala Pro Leu Gly Glu Leu Val Leu Pro Ser Gly Ala Phe Arg 
            580                 585                 590         


Arg Ala Asp Gly Lys Pro Tyr Ser Gly Pro Val Glu Ala Arg Val Thr 
        595                 600                 605             


Phe Val Asp Pro Arg Asp Leu Thr Ser Ala Ala Ser Ala Pro Ser Asp 
    610                 615                 620                 


Leu Arg Phe Val Asp Ser Asp Gly Glu Leu Ala Pro Leu Arg Thr Tyr 
625                 630                 635                 640 


Gly Met Phe Ser Val Asp Leu Arg Ala Pro Gly Ser Ala Glu Gln Leu 
                645                 650                 655     


Gln Val Gly Pro Val Ala Val Arg Val Ala Ala Ser Gln Ile His Met 
            660                 665                 670         


Pro Gly His Val Glu Ala Leu Lys Leu Trp Ser Leu Asn Pro Glu Thr 
        675                 680                 685             


Gly Leu Trp Glu Glu Glu Ser Gly Phe Arg Arg Glu Gly Ser Ser Gly 
    690                 695                 700                 


Pro Arg Val Arg Arg Glu Glu Arg Val Phe Leu Val Gly Asn Val Glu 
705                 710                 715                 720 


Ile Arg Glu Arg Arg Leu Phe Asn Leu Asp Val Pro Glu Arg Arg Arg 
                725                 730                 735     


Cys Phe Val Lys Val Arg Ala Tyr Ala Asn Asp Lys Phe Thr Pro Ser 
            740                 745                 750         


Glu Gln Val Glu Gly Val Val Val Thr Leu Val Asn Leu Glu Pro Ala 
        755                 760                 765             


Pro Gly Phe Ser Ala Asn Pro Arg Ala Trp Gly Arg Phe Asp Ser Ala 
    770                 775                 780                 


Val Thr Gly Pro Asn Gly Ala Cys Leu Pro Ala Phe Cys Asp Ala Asp 
785                 790                 795                 800 


Arg Pro Asp Ala Tyr Thr Ala Leu Val Thr Ala Thr Leu Gly Gly Glu 
                805                 810                 815     


Glu Leu Glu Pro Ala Pro Ser Leu Pro Arg Pro Leu Pro Ala Thr Val 
            820                 825                 830         


Gly Val Thr Gln Pro Tyr Leu Asp Arg Leu Gly Tyr Arg Arg Thr Asp 
        835                 840                 845             


His Asp Asp Pro Ala Phe Lys Arg Asn Gly Phe Arg Ile Asn Leu Ala 
    850                 855                 860                 


Lys Pro Arg Pro Gly Asp Pro Ala Glu Ala Asn Gly Pro Val Tyr Pro 
865                 870                 875                 880 


Trp Arg Ser Leu Arg Glu Cys Gln Gly Ala Pro Val Thr Ala Ser His 
                885                 890                 895     


Phe Arg Phe Ala Arg Val Glu Ala Asp Lys Tyr Glu Tyr Asn Val Val 
            900                 905                 910         


Pro Phe Arg Glu Gly Thr Pro Ala Ser Trp Thr Gly Asp Leu Leu Ala 
        915                 920                 925             


Trp Trp Pro Asn Pro Gln Glu Phe Arg Ala Cys Phe Leu Lys Val Lys 
    930                 935                 940                 


Ile Gln Gly Pro Gln Glu Tyr Met Val Arg Ser His Asn Ala Gly Gly 
945                 950                 955                 960 


Ser His Pro Arg Thr Arg Gly Gln Leu Tyr Gly Leu Arg Asp Ala Arg 
                965                 970                 975     


Ser Val Arg Asp Pro Glu Arg Pro Gly Thr Ser Ala Ala Cys Val Glu 
            980                 985                 990         


Phe Lys Cys Ser Gly Met Leu Phe  Asp Gln Arg Gln Val  Asp Arg Thr 
        995                 1000                 1005             


Leu Val  Thr Ile Met Pro Gln  Gly Ser Cys Arg Arg  Val Ala Val 
    1010                 1015                 1020             


Asn Gly  Leu Leu Arg Asp Tyr  Leu Thr Arg His Pro  Pro Pro Val 
    1025                 1030                 1035             


Pro Ala  Glu Asp Pro Ala Ala  Phe Ser Met Leu Ala  Pro Leu Asp 
    1040                 1045                 1050             


Pro Leu  Gly His Asn Tyr Gly  Val Tyr Thr Val Thr  Asp Gln Ser 
    1055                 1060                 1065             


Pro Arg  Leu Ala Lys Glu Ile  Ala Ile Gly Arg Cys  Phe Asp Gly 
    1070                 1075                 1080             


Ser Ser  Asp Gly Phe Ser Arg  Glu Met Lys Ala Asp  Ala Gly Thr 
    1085                 1090                 1095             


Ala Val  Thr Phe Gln Cys Arg  Glu Pro Pro Ala Gly  Arg Pro Ser 
    1100                 1105                 1110             


Leu Phe  Gln Arg Leu Leu Glu  Ser Pro Ala Thr Ala  Leu Gly Asp 
    1115                 1120                 1125             


Ile Arg  Arg Glu Met Ser Glu  Ala Ala Gln Ala Gln  Ala Arg Ala 
    1130                 1135                 1140             


Ser Gly  Pro Leu Arg Thr Arg  Arg Gly Arg Val Arg  Gln 
    1145                 1150                 1155     


<210>  2202
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CILP__Homo_sapiens__NP_003604

<400>  2202

Met Val Gly Thr Lys Ala Trp Val Phe Ser Phe Leu Val Leu Glu Val 
1               5                   10                  15      


Thr Ser Val Leu Gly Arg Gln Thr Met Leu Thr Gln Ser Val Arg Arg 
            20                  25                  30          


Val Gln Pro Gly Lys Lys Asn Pro Ser Ile Phe Ala Lys Pro Ala Asp 
        35                  40                  45              


Thr Leu Glu Ser Pro Gly Glu Trp Thr Thr Trp Phe Asn Ile Asp Tyr 
    50                  55                  60                  


Pro Gly Gly Lys Gly Asp Tyr Glu Arg Leu Asp Ala Ile Arg Phe Tyr 
65                  70                  75                  80  


Tyr Gly Asp Arg Val Cys Ala Arg Pro Leu Arg Leu Glu Ala Arg Thr 
                85                  90                  95      


Thr Asp Trp Thr Pro Ala Gly Ser Thr Gly Gln Val Val His Gly Ser 
            100                 105                 110         


Pro Arg Glu Gly Phe Trp Cys Leu Asn Arg Glu Gln Arg Pro Gly Gln 
        115                 120                 125             


Asn Cys Ser Asn Tyr Thr Val Arg Phe Leu Cys Pro Pro Gly Ser Leu 
    130                 135                 140                 


Arg Arg Asp Thr Glu Arg Ile Trp Ser Pro Trp Ser Pro Trp Ser Lys 
145                 150                 155                 160 


Cys Ser Ala Ala Cys Gly Gln Thr Gly Val Gln Thr Arg Thr Arg Ile 
                165                 170                 175     


Cys Leu Ala Glu Met Val Ser Leu Cys Ser Glu Ala Ser Glu Glu Gly 
            180                 185                 190         


Gln His Cys Met Gly Gln Asp Cys Thr Ala Cys Asp Leu Thr Cys Pro 
        195                 200                 205             


Met Gly Gln Val Asn Ala Asp Cys Asp Ala Cys Met Cys Gln Asp Phe 
    210                 215                 220                 


Met Leu His Gly Ala Val Ser Leu Pro Gly Gly Ala Pro Ala Ser Gly 
225                 230                 235                 240 


Ala Ala Ile Tyr Leu Leu Thr Lys Thr Pro Lys Leu Leu Thr Gln Thr 
                245                 250                 255     


Asp Ser Asp Gly Arg Phe Arg Ile Pro Gly Leu Cys Pro Asp Gly Lys 
            260                 265                 270         


Ser Ile Leu Lys Ile Thr Lys Val Lys Phe Ala Pro Ile Val Leu Thr 
        275                 280                 285             


Met Pro Lys Thr Ser Leu Lys Ala Ala Thr Ile Lys Ala Glu Phe Val 
    290                 295                 300                 


Arg Ala Glu Thr Pro Tyr Met Val Met Asn Pro Glu Thr Lys Ala Arg 
305                 310                 315                 320 


Arg Ala Gly Gln Ser Val Ser Leu Cys Cys Lys Ala Thr Gly Lys Pro 
                325                 330                 335     


Arg Pro Asp Lys Tyr Phe Trp Tyr His Asn Asp Thr Leu Leu Asp Pro 
            340                 345                 350         


Ser Leu Tyr Lys His Glu Ser Lys Leu Val Leu Arg Lys Leu Gln Gln 
        355                 360                 365             


His Gln Ala Gly Glu Tyr Phe Cys Lys Ala Gln Ser Asp Ala Gly Ala 
    370                 375                 380                 


Val Lys Ser Lys Val Ala Gln Leu Ile Val Ile Ala Ser Asp Glu Thr 
385                 390                 395                 400 


Pro Cys Asn Pro Val Pro Glu Ser Tyr Leu Ile Arg Leu Pro His Asp 
                405                 410                 415     


Cys Phe Gln Asn Ala Thr Asn Ser Phe Tyr Tyr Asp Val Gly Arg Cys 
            420                 425                 430         


Pro Val Lys Thr Cys Ala Gly Gln Gln Asp Asn Gly Ile Arg Cys Arg 
        435                 440                 445             


Asp Ala Val Gln Asn Cys Cys Gly Ile Ser Lys Thr Glu Glu Arg Glu 
    450                 455                 460                 


Ile Gln Cys Ser Gly Tyr Thr Leu Pro Thr Lys Val Ala Lys Glu Cys 
465                 470                 475                 480 


Ser Cys Gln Arg Cys Thr Glu Thr Arg Ser Ile Val Arg Gly Arg Val 
                485                 490                 495     


Ser Ala Ala Asp Asn Gly Glu Pro Met Arg Phe Gly His Val Tyr Met 
            500                 505                 510         


Gly Asn Ser Arg Val Ser Met Thr Gly Tyr Lys Gly Thr Phe Thr Leu 
        515                 520                 525             


His Val Pro Gln Asp Thr Glu Arg Leu Val Leu Thr Phe Val Asp Arg 
    530                 535                 540                 


Leu Gln Lys Phe Val Asn Thr Thr Lys Val Leu Pro Phe Asn Lys Lys 
545                 550                 555                 560 


Gly Ser Ala Val Phe His Glu Ile Lys Met Leu Arg Arg Lys Glu Pro 
                565                 570                 575     


Ile Thr Leu Glu Ala Met Glu Thr Asn Ile Ile Pro Leu Gly Glu Val 
            580                 585                 590         


Val Gly Glu Asp Pro Met Ala Glu Leu Glu Ile Pro Ser Arg Ser Phe 
        595                 600                 605             


Tyr Arg Gln Asn Gly Glu Pro Tyr Ile Gly Lys Val Lys Ala Ser Val 
    610                 615                 620                 


Thr Phe Leu Asp Pro Arg Asn Ile Ser Thr Ala Thr Ala Ala Gln Thr 
625                 630                 635                 640 


Asp Leu Asn Phe Ile Asn Asp Glu Gly Asp Thr Phe Pro Leu Arg Thr 
                645                 650                 655     


Tyr Gly Met Phe Ser Val Asp Phe Arg Asp Glu Val Thr Ser Glu Pro 
            660                 665                 670         


Leu Asn Ala Gly Lys Val Lys Val His Leu Asp Ser Thr Gln Val Lys 
        675                 680                 685             


Met Pro Glu His Ile Ser Thr Val Lys Leu Trp Ser Leu Asn Pro Asp 
    690                 695                 700                 


Thr Gly Leu Trp Glu Glu Glu Gly Asp Phe Lys Phe Glu Asn Gln Arg 
705                 710                 715                 720 


Arg Asn Lys Arg Glu Asp Arg Thr Phe Leu Val Gly Asn Leu Glu Ile 
                725                 730                 735     


Arg Glu Arg Arg Leu Phe Asn Leu Asp Val Pro Glu Ser Arg Arg Cys 
            740                 745                 750         


Phe Val Lys Val Arg Ala Tyr Arg Ser Glu Arg Phe Leu Pro Ser Glu 
        755                 760                 765             


Gln Ile Gln Gly Val Val Ile Ser Val Ile Asn Leu Glu Pro Arg Thr 
    770                 775                 780                 


Gly Phe Leu Ser Asn Pro Arg Ala Trp Gly Arg Phe Asp Ser Val Ile 
785                 790                 795                 800 


Thr Gly Pro Asn Gly Ala Cys Val Pro Ala Phe Cys Asp Asp Gln Ser 
                805                 810                 815     


Pro Asp Ala Tyr Ser Ala Tyr Val Leu Ala Ser Leu Ala Gly Glu Glu 
            820                 825                 830         


Leu Gln Ala Val Glu Ser Ser Pro Lys Phe Asn Pro Asn Ala Ile Gly 
        835                 840                 845             


Val Pro Gln Pro Tyr Leu Asn Lys Leu Asn Tyr Arg Arg Thr Asp His 
    850                 855                 860                 


Glu Asp Pro Arg Val Lys Lys Thr Ala Phe Gln Ile Ser Met Ala Lys 
865                 870                 875                 880 


Pro Arg Pro Asn Ser Ala Glu Glu Ser Asn Gly Pro Ile Tyr Ala Phe 
                885                 890                 895     


Glu Asn Leu Arg Ala Cys Glu Glu Ala Pro Pro Ser Ala Ala His Phe 
            900                 905                 910         


Arg Phe Tyr Gln Ile Glu Gly Asp Arg Tyr Asp Tyr Asn Thr Val Pro 
        915                 920                 925             


Phe Asn Glu Asp Asp Pro Met Ser Trp Thr Glu Asp Tyr Leu Ala Trp 
    930                 935                 940                 


Trp Pro Lys Pro Met Glu Phe Arg Ala Cys Tyr Ile Lys Val Lys Ile 
945                 950                 955                 960 


Val Gly Pro Leu Glu Val Asn Val Arg Ser Arg Asn Met Gly Gly Thr 
                965                 970                 975     


His Arg Gln Thr Val Gly Lys Leu Tyr Gly Ile Arg Asp Val Arg Ser 
            980                 985                 990         


Thr Arg Asp Arg Asp Gln Pro Asn  Val Ser Ala Ala Cys  Leu Glu Phe 
        995                 1000                 1005             


Lys Cys  Ser Gly Met Leu Tyr  Asp Gln Asp Arg Val  Asp Arg Thr 
    1010                 1015                 1020             


Leu Val  Lys Val Ile Pro Gln  Gly Ser Cys Arg Arg  Ala Ser Val 
    1025                 1030                 1035             


Asn Pro  Met Leu His Glu Tyr  Leu Val Asn His Leu  Pro Leu Ala 
    1040                 1045                 1050             


Val Asn  Asn Asp Thr Ser Glu  Tyr Thr Met Leu Ala  Pro Leu Asp 
    1055                 1060                 1065             


Pro Leu  Gly His Asn Tyr Gly  Ile Tyr Thr Val Thr  Asp Gln Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ala Lys Glu Ile  Ala Leu Gly Arg Cys  Phe Asp Gly 
    1085                 1090                 1095             


Thr Ser  Asp Gly Ser Ser Arg  Ile Met Lys Ser Asn  Val Gly Val 
    1100                 1105                 1110             


Ala Leu  Thr Phe Asn Cys Val  Glu Arg Gln Val Gly  Arg Gln Ser 
    1115                 1120                 1125             


Ala Phe  Gln Tyr Leu Gln Ser  Thr Pro Ala Gln Ser  Pro Ala Ala 
    1130                 1135                 1140             


Gly Thr  Val Gln Gly Arg Val  Pro Ser Arg Arg Gln  Gln Arg Ala 
    1145                 1150                 1155             


Ser Arg  Gly Gly Gln Arg Gln  Gly Gly Val Val Ala  Ser Leu Arg 
    1160                 1165                 1170             


Phe Pro  Arg Val Ala Gln Gln  Pro Leu Ile Asn 
    1175                 1180                 


<210>  2203
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CINP__Homo_sapiens__NP_116019

<400>  2203

Met Glu Ala Lys Thr Leu Gly Thr Val Thr Pro Arg Lys Pro Val Leu 
1               5                   10                  15      


Ser Val Ser Ala Arg Lys Ile Lys Asp Asn Ala Ala Asp Trp His Asn 
            20                  25                  30          


Leu Ile Leu Lys Trp Glu Thr Leu Asn Asp Ala Gly Phe Thr Thr Ala 
        35                  40                  45              


Asn Asn Ile Ala Asn Leu Lys Ile Ser Leu Leu Asn Lys Asp Lys Ile 
    50                  55                  60                  


Glu Leu Asp Ser Ser Ser Pro Ala Ser Lys Glu Asn Glu Glu Lys Val 
65                  70                  75                  80  


Cys Leu Glu Tyr Asn Glu Glu Leu Glu Lys Leu Cys Glu Glu Leu Gln 
                85                  90                  95      


Ala Thr Leu Asp Gly Leu Thr Lys Ile Gln Val Lys Met Glu Lys Leu 
            100                 105                 110         


Ser Ser Thr Thr Lys Gly Ile Cys Glu Leu Glu Asn Tyr His Tyr Gly 
        115                 120                 125             


Glu Glu Ser Lys Arg Pro Pro Leu Phe His Thr Trp Pro Thr Thr His 
    130                 135                 140                 


Phe Tyr Glu Val Ser His Lys Leu Leu Glu Met Tyr Arg Lys Glu Leu 
145                 150                 155                 160 


Leu Leu Lys Arg Thr Val Ala Lys Glu Leu Ala His Thr Gly Asp Pro 
                165                 170                 175     


Asp Leu Thr Leu Ser Tyr Leu Ser Met Trp Leu His Gln Pro Tyr Val 
            180                 185                 190         


Glu Ser Asp Ser Arg Leu His Leu Glu Ser Met Leu Leu Glu Thr Gly 
        195                 200                 205             


His Arg Ala Leu 
    210         


<210>  2204
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIPC__Homo_sapiens__NP_219494

<400>  2204

Met Glu Arg Lys Asn Pro Ser Arg Glu Ser Pro Arg Arg Leu Ser Ala 
1               5                   10                  15      


Lys Val Gly Lys Gly Thr Glu Met Lys Lys Val Ala Arg Gln Leu Gly 
            20                  25                  30          


Met Ala Ala Ala Glu Ser Asp Lys Asp Ser Gly Phe Ser Asp Gly Ser 
        35                  40                  45              


Ser Glu Cys Leu Ser Ser Ala Glu Gln Met Glu Ser Glu Asp Met Leu 
    50                  55                  60                  


Ser Ala Leu Gly Trp Ser Arg Glu Asp Arg Pro Arg Gln Asn Ser Lys 
65                  70                  75                  80  


Thr Ala Lys Asn Ala Phe Pro Thr Leu Ser Pro Met Val Val Met Lys 
                85                  90                  95      


Asn Val Leu Val Lys Gln Gly Ser Ser Ser Ser Gln Leu Gln Ser Trp 
            100                 105                 110         


Thr Val Gln Pro Ser Phe Glu Val Ile Ser Ala Gln Pro Gln Leu Leu 
        115                 120                 125             


Phe Leu His Pro Pro Val Pro Ser Pro Val Ser Pro Cys His Thr Gly 
    130                 135                 140                 


Glu Lys Lys Ser Asp Ser Arg Asn Tyr Leu Pro Ile Leu Asn Ser Tyr 
145                 150                 155                 160 


Thr Lys Ile Ala Pro His Pro Gly Lys Arg Gly Leu Ser Leu Gly Pro 
                165                 170                 175     


Glu Glu Lys Gly Thr Ser Gly Val Gln Lys Lys Ile Cys Thr Glu Arg 
            180                 185                 190         


Leu Gly Pro Ser Leu Ser Ser Ser Glu Pro Thr Lys Ala Gly Ala Val 
        195                 200                 205             


Pro Ser Ser Pro Ser Thr Pro Ala Pro Pro Ser Ala Lys Leu Ala Glu 
    210                 215                 220                 


Asp Ser Ala Leu Gln Gly Val Pro Ser Leu Val Ala Gly Gly Ser Pro 
225                 230                 235                 240 


Gln Thr Leu Gln Pro Val Ser Ser Ser His Val Ala Lys Ala Pro Ser 
                245                 250                 255     


Leu Thr Phe Ala Ser Pro Ala Ser Pro Val Cys Ala Ser Asp Ser Thr 
            260                 265                 270         


Leu His Gly Leu Glu Ser Asn Ser Pro Leu Ser Pro Leu Ser Ala Asn 
        275                 280                 285             


Tyr Ser Ser Pro Leu Trp Ala Ala Glu His Leu Cys Arg Ser Pro Asp 
    290                 295                 300                 


Ile Phe Ser Glu Gln Arg Gln Ser Lys His Arg Arg Phe Gln Asn Thr 
305                 310                 315                 320 


Leu Val Val Leu His Lys Ser Gly Leu Leu Glu Ile Thr Leu Lys Thr 
                325                 330                 335     


Lys Glu Leu Ile Arg Gln Asn Gln Ala Thr Gln Val Glu Leu Asp Gln 
            340                 345                 350         


Leu Lys Glu Gln Thr Gln Leu Phe Ile Glu Ala Thr Lys Ser Arg Ala 
        355                 360                 365             


Pro Gln Ala Trp Ala Lys Leu Gln Ala Ser Leu Thr Pro Gly Ser Ser 
    370                 375                 380                 


Asn Thr Gly Ser Asp Leu Glu Ala Phe Ser Asp His Pro Ala Ile 
385                 390                 395                 


<210>  2205
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIR1__Homo_sapiens__NP_004873

<400>  2205

Met Gly Lys Ser Phe Ala Asn Phe Met Cys Lys Lys Asp Phe His Pro 
1               5                   10                  15      


Ala Ser Lys Ser Asn Ile Lys Lys Val Trp Met Ala Glu Gln Lys Ile 
            20                  25                  30          


Ser Tyr Asp Lys Lys Lys Gln Glu Glu Leu Met Gln Gln Tyr Leu Lys 
        35                  40                  45              


Glu Gln Glu Ser Tyr Asp Asn Arg Leu Leu Met Gly Asp Glu Arg Val 
    50                  55                  60                  


Lys Asn Gly Leu Asn Phe Met Tyr Glu Ala Pro Pro Gly Ala Lys Lys 
65                  70                  75                  80  


Glu Asn Lys Glu Lys Glu Glu Thr Glu Gly Glu Thr Glu Tyr Lys Phe 
                85                  90                  95      


Glu Trp Gln Lys Gly Ala Pro Arg Glu Lys Tyr Ala Lys Asp Asp Met 
            100                 105                 110         


Asn Ile Arg Asp Gln Pro Phe Gly Ile Gln Val Arg Asn Val Arg Cys 
        115                 120                 125             


Ile Lys Cys His Lys Trp Gly His Val Asn Thr Asp Arg Glu Cys Pro 
    130                 135                 140                 


Leu Phe Gly Leu Ser Gly Ile Asn Ala Ser Ser Val Pro Thr Asp Gly 
145                 150                 155                 160 


Ser Gly Pro Ser Met His Pro Ser Glu Leu Ile Ala Glu Met Arg Asn 
                165                 170                 175     


Ser Gly Phe Ala Leu Lys Arg Asn Val Leu Gly Arg Asn Leu Thr Ala 
            180                 185                 190         


Asn Asp Pro Ser Gln Glu Tyr Val Ala Ser Glu Gly Glu Glu Asp Pro 
        195                 200                 205             


Glu Val Glu Phe Leu Lys Ser Leu Thr Thr Lys Gln Lys Gln Lys Leu 
    210                 215                 220                 


Leu Arg Lys Leu Asp Arg Leu Glu Lys Lys Lys Lys Lys Lys Asp Arg 
225                 230                 235                 240 


Lys Lys Lys Lys Phe Gln Lys Ser Arg Ser Lys His Lys Lys His Lys 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Glu 
            260                 265                 270         


Thr Ser Glu Ser Ser Ser Glu Ser Glu Ser Asn Asn Lys Glu Lys Lys 
        275                 280                 285             


Ile Gln Arg Lys Lys Arg Lys Lys Asn Lys Cys Ser Gly His Asn Asn 
    290                 295                 300                 


Ser Asp Ser Glu Glu Lys Asp Lys Ser Lys Lys Arg Lys Leu His Glu 
305                 310                 315                 320 


Glu Leu Ser Ser Ser His His Asn Arg Glu Lys Ala Lys Glu Lys Pro 
                325                 330                 335     


Arg Phe Leu Lys His Glu Ser Ser Arg Glu Asp Ser Lys Trp Ser His 
            340                 345                 350         


Ser Asp Ser Asp Lys Lys Ser Arg Thr His Lys His Ser Pro Glu Lys 
        355                 360                 365             


Arg Gly Ser Glu Arg Lys Glu Gly Ser Ser Arg Ser His Gly Arg Glu 
    370                 375                 380                 


Glu Arg Ser Arg Arg Ser Arg Ser Arg Ser Pro Gly Ser Tyr Lys Gln 
385                 390                 395                 400 


Arg Glu Thr Arg Lys Arg Ala Gln Arg Asn Pro Gly Glu Glu Gln Ser 
                405                 410                 415     


Arg Arg Asn Asp Ser Arg Ser His Gly Thr Asp Leu Tyr Arg Gly Glu 
            420                 425                 430         


Lys Met Tyr Arg Glu His Pro Gly Gly Thr His Thr Lys Val Thr Gln 
        435                 440                 445             


Arg Glu 
    450 


<210>  2206
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIRBP__Homo_sapiens__NP_001287744

<400>  2206

Met Ala Ser Asp Glu Gly Lys Leu Phe Val Gly Gly Leu Ser Phe Asp 
1               5                   10                  15      


Thr Asn Glu Gln Ser Leu Glu Gln Val Phe Ser Lys Tyr Gly Gln Ile 
            20                  25                  30          


Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly 
        35                  40                  45              


Phe Gly Phe Val Thr Phe Glu Asn Ile Asp Asp Ala Lys Asp Ala Met 
    50                  55                  60                  


Met Ala Met Asn Gly Lys Ser Val Asp Gly Arg Gln Ile Arg Val Asp 
65                  70                  75                  80  


Gln Ala Gly Lys Ser Ser Asp Asn Arg Ser Arg Gly Tyr Arg Gly Gly 
                85                  90                  95      


Ser Ala Gly Gly Arg Gly Phe Phe Arg Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Phe Ser Arg Gly Gly Gly Asp Arg Gly Tyr Gly Gly Asn Arg Phe 
        115                 120                 125             


Glu Ser Arg Ser Gly Gly Tyr Gly Gly Ser Arg Asp Tyr Tyr Ser Ser 
    130                 135                 140                 


Arg Ser Gln Ser Gly Gly Tyr Ser Asp Arg Ser Ser Gly Gly Ser Tyr 
145                 150                 155                 160 


Arg Asp Ser Tyr Asp Ser Tyr Gly 
                165             


<210>  2207
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIRH1A__Homo_sapiens__NP_116219

<400>  2207

Met Gly Glu Phe Lys Val His Arg Val Arg Phe Phe Asn Tyr Val Pro 
1               5                   10                  15      


Ser Gly Ile Arg Cys Val Ala Tyr Asn Asn Gln Ser Asn Arg Leu Ala 
            20                  25                  30          


Val Ser Arg Thr Asp Gly Thr Val Glu Ile Tyr Asn Leu Ser Ala Asn 
        35                  40                  45              


Tyr Phe Gln Glu Lys Phe Phe Pro Gly His Glu Ser Arg Ala Thr Glu 
    50                  55                  60                  


Ala Leu Cys Trp Ala Glu Gly Gln Arg Leu Phe Ser Ala Gly Leu Asn 
65                  70                  75                  80  


Gly Glu Ile Met Glu Tyr Asp Leu Gln Ala Leu Asn Ile Lys Tyr Ala 
                85                  90                  95      


Met Asp Ala Phe Gly Gly Pro Ile Trp Ser Met Ala Ala Ser Pro Ser 
            100                 105                 110         


Gly Ser Gln Leu Leu Val Gly Cys Glu Asp Gly Ser Val Lys Leu Phe 
        115                 120                 125             


Gln Ile Thr Pro Asp Lys Ile Gln Phe Glu Arg Asn Phe Asp Arg Gln 
    130                 135                 140                 


Lys Ser Arg Ile Leu Ser Leu Ser Trp His Pro Ser Gly Thr His Ile 
145                 150                 155                 160 


Ala Ala Gly Ser Ile Asp Tyr Ile Ser Val Phe Asp Val Lys Ser Gly 
                165                 170                 175     


Ser Ala Val His Lys Met Ile Val Asp Arg Gln Tyr Met Gly Val Ser 
            180                 185                 190         


Lys Arg Lys Cys Ile Val Trp Gly Val Ala Phe Leu Ser Asp Gly Thr 
        195                 200                 205             


Ile Ile Ser Val Asp Ser Ala Gly Lys Val Gln Phe Trp Asp Ser Ala 
    210                 215                 220                 


Thr Gly Thr Leu Val Lys Ser His Leu Ile Ala Asn Ala Asp Val Gln 
225                 230                 235                 240 


Ser Ile Ala Val Ala Asp Gln Glu Asp Ser Phe Val Val Gly Thr Ala 
                245                 250                 255     


Glu Gly Thr Val Phe His Phe Gln Leu Val Pro Val Thr Ser Asn Ser 
            260                 265                 270         


Ser Glu Lys Gln Trp Val Arg Thr Lys Pro Phe Gln His His Thr His 
        275                 280                 285             


Asp Val Arg Thr Val Ala His Ser Pro Thr Ala Leu Ile Ser Gly Gly 
    290                 295                 300                 


Thr Asp Thr His Leu Val Phe Arg Pro Leu Met Glu Lys Val Glu Val 
305                 310                 315                 320 


Lys Asn Tyr Asp Ala Ala Leu Arg Lys Ile Thr Phe Pro His Arg Cys 
                325                 330                 335     


Leu Ile Ser Cys Ser Lys Lys Arg Gln Leu Leu Leu Phe Gln Phe Ala 
            340                 345                 350         


His His Leu Glu Leu Trp Arg Leu Gly Ser Thr Val Ala Thr Gly Lys 
        355                 360                 365             


Asn Gly Asp Thr Leu Pro Leu Ser Lys Asn Ala Asp His Leu Leu His 
    370                 375                 380                 


Leu Lys Thr Lys Gly Pro Glu Asn Ile Ile Cys Ser Cys Ile Ser Pro 
385                 390                 395                 400 


Cys Gly Ser Trp Ile Ala Tyr Ser Thr Val Ser Arg Phe Phe Leu Tyr 
                405                 410                 415     


Arg Leu Asn Tyr Glu His Asp Asn Ile Ser Leu Lys Arg Val Ser Lys 
            420                 425                 430         


Met Pro Ala Phe Leu Arg Ser Ala Leu Gln Ile Leu Phe Ser Glu Asp 
        435                 440                 445             


Ser Thr Lys Leu Phe Val Ala Ser Asn Gln Gly Ala Leu His Ile Val 
    450                 455                 460                 


Gln Leu Ser Gly Gly Ser Phe Lys His Leu His Ala Phe Gln Pro Gln 
465                 470                 475                 480 


Ser Gly Thr Val Glu Ala Met Cys Leu Leu Ala Val Ser Pro Asp Gly 
                485                 490                 495     


Asn Trp Leu Ala Ala Ser Gly Thr Ser Ala Gly Val His Val Tyr Asn 
            500                 505                 510         


Val Lys Gln Leu Lys Leu His Cys Thr Val Pro Ala Tyr Asn Phe Pro 
        515                 520                 525             


Val Thr Ala Met Ala Ile Ala Pro Asn Thr Asn Asn Leu Val Ile Ala 
    530                 535                 540                 


His Ser Asp Gln Gln Val Phe Glu Tyr Ser Ile Pro Asp Lys Gln Tyr 
545                 550                 555                 560 


Thr Asp Trp Ser Arg Thr Val Gln Lys Gln Gly Phe His His Leu Trp 
                565                 570                 575     


Leu Gln Arg Asp Thr Pro Ile Thr His Ile Ser Phe His Pro Lys Arg 
            580                 585                 590         


Pro Met His Ile Leu Leu His Asp Ala Tyr Met Phe Cys Ile Ile Asp 
        595                 600                 605             


Lys Ser Leu Pro Leu Pro Asn Asp Lys Thr Leu Leu Tyr Asn Pro Phe 
    610                 615                 620                 


Pro Pro Thr Asn Glu Ser Asp Val Ile Arg Arg Arg Thr Ala His Ala 
625                 630                 635                 640 


Phe Lys Ile Ser Lys Ile Tyr Lys Pro Leu Leu Phe Met Asp Leu Leu 
                645                 650                 655     


Asp Glu Arg Thr Leu Val Ala Val Glu Arg Pro Leu Asp Asp Ile Ile 
            660                 665                 670         


Ala Gln Leu Pro Pro Pro Ile Lys Lys Lys Lys Phe Gly Thr 
        675                 680                 685     


<210>  2208
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CISD1__Homo_sapiens__NP_060934

<400>  2208

Met Ser Leu Thr Ser Ser Ser Ser Val Arg Val Glu Trp Ile Ala Ala 
1               5                   10                  15      


Val Thr Ile Ala Ala Gly Thr Ala Ala Ile Gly Tyr Leu Ala Tyr Lys 
            20                  25                  30          


Arg Phe Tyr Val Lys Asp His Arg Asn Lys Ala Met Ile Asn Leu His 
        35                  40                  45              


Ile Gln Lys Asp Asn Pro Lys Ile Val His Ala Phe Asp Met Glu Asp 
    50                  55                  60                  


Leu Gly Asp Lys Ala Val Tyr Cys Arg Cys Trp Arg Ser Lys Lys Phe 
65                  70                  75                  80  


Pro Phe Cys Asp Gly Ala His Thr Lys His Asn Glu Glu Thr Gly Asp 
                85                  90                  95      


Asn Val Gly Pro Leu Ile Ile Lys Lys Lys Glu Thr 
            100                 105             


<210>  2209
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CISD2__Homo_sapiens__NP_001008389

<400>  2209

Met Val Leu Glu Ser Val Ala Arg Ile Val Lys Val Gln Leu Pro Ala 
1               5                   10                  15      


Tyr Leu Lys Arg Leu Pro Val Pro Glu Ser Ile Thr Gly Phe Ala Arg 
            20                  25                  30          


Leu Thr Val Ser Glu Trp Leu Arg Leu Leu Pro Phe Leu Gly Val Leu 
        35                  40                  45              


Ala Leu Leu Gly Tyr Leu Ala Val Arg Pro Phe Leu Pro Lys Lys Lys 
    50                  55                  60                  


Gln Gln Lys Asp Ser Leu Ile Asn Leu Lys Ile Gln Lys Glu Asn Pro 
65                  70                  75                  80  


Lys Val Val Asn Glu Ile Asn Ile Glu Asp Leu Cys Leu Thr Lys Ala 
                85                  90                  95      


Ala Tyr Cys Arg Cys Trp Arg Ser Lys Thr Phe Pro Ala Cys Asp Gly 
            100                 105                 110         


Ser His Asn Lys His Asn Glu Leu Thr Gly Asp Asn Val Gly Pro Leu 
        115                 120                 125             


Ile Leu Lys Lys Lys Glu Val 
    130                 135 


<210>  2210
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CISH__Homo_sapiens__NP_037456

<400>  2210

Met Tyr Leu Glu His Thr Ser His Cys Pro His His Asp Asp Asp Thr 
1               5                   10                  15      


Ala Met Asp Thr Pro Leu Pro Arg Pro Arg Pro Leu Leu Ala Val Glu 
            20                  25                  30          


Arg Thr Gly Gln Arg Pro Leu Trp Ala Pro Ser Leu Glu Leu Pro Lys 
        35                  40                  45              


Pro Val Met Gln Pro Leu Pro Ala Gly Ala Phe Leu Glu Glu Val Ala 
    50                  55                  60                  


Glu Gly Thr Pro Ala Gln Thr Glu Ser Glu Pro Lys Val Leu Asp Pro 
65                  70                  75                  80  


Glu Glu Asp Leu Leu Cys Ile Ala Lys Thr Phe Ser Tyr Leu Arg Glu 
                85                  90                  95      


Ser Gly Trp Tyr Trp Gly Ser Ile Thr Ala Ser Glu Ala Arg Gln His 
            100                 105                 110         


Leu Gln Lys Met Pro Glu Gly Thr Phe Leu Val Arg Asp Ser Thr His 
        115                 120                 125             


Pro Ser Tyr Leu Phe Thr Leu Ser Val Lys Thr Thr Arg Gly Pro Thr 
    130                 135                 140                 


Asn Val Arg Ile Glu Tyr Ala Asp Ser Ser Phe Arg Leu Asp Ser Asn 
145                 150                 155                 160 


Cys Leu Ser Arg Pro Arg Ile Leu Ala Phe Pro Asp Val Val Ser Leu 
                165                 170                 175     


Val Gln His Tyr Val Ala Ser Cys Thr Ala Asp Thr Arg Ser Asp Ser 
            180                 185                 190         


Pro Asp Pro Ala Pro Thr Pro Ala Leu Pro Met Pro Lys Glu Asp Ala 
        195                 200                 205             


Pro Ser Asp Pro Ala Leu Pro Ala Pro Pro Pro Ala Thr Ala Val His 
    210                 215                 220                 


Leu Lys Leu Val Gln Pro Phe Val Arg Arg Ser Ser Ala Arg Ser Leu 
225                 230                 235                 240 


Gln His Leu Cys Arg Leu Val Ile Asn Arg Leu Val Ala Asp Val Asp 
                245                 250                 255     


Cys Leu Pro Leu Pro Arg Arg Met Ala Asp Tyr Leu Arg Gln Tyr Pro 
            260                 265                 270         


Phe Gln Leu 
        275 


<210>  2211
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CITED1__Homo_sapiens__NP_001138357

<400>  2211

Met Glu Pro Ser Ala Gln Gln Leu Gln Leu Ala Ala Ser Leu Pro Ala 
1               5                   10                  15      


Asn Leu Ser Asn Phe Cys Gln Gly Ser Glu Met Pro Thr Thr Ser Arg 
            20                  25                  30          


Pro Ala Leu Asp Val Lys Gly Gly Thr Ser Pro Ala Lys Glu Asp Ala 
        35                  40                  45              


Asn Gln Glu Met Ser Ser Val Ala Tyr Ser Asn Leu Ala Val Lys Asp 
    50                  55                  60                  


Arg Lys Ala Val Ala Ile Leu His Tyr Pro Gly Val Ala Ser Asn Gly 
65                  70                  75                  80  


Thr Lys Ala Ser Gly Ala Pro Thr Ser Ser Ser Gly Ser Pro Ile Gly 
                85                  90                  95      


Ser Pro Thr Thr Thr Pro Pro Thr Lys Pro Pro Ser Phe Asn Leu His 
            100                 105                 110         


Pro Ala Pro His Leu Leu Ala Ser Met His Leu Gln Lys Leu Asn Ser 
        115                 120                 125             


Gln Tyr Gln Gly Met Ala Ala Ala Thr Pro Gly Gln Pro Gly Glu Ala 
    130                 135                 140                 


Gly Pro Leu Gln Asn Trp Asp Phe Gly Ala Gln Ala Gly Gly Ala Glu 
145                 150                 155                 160 


Ser Leu Ser Pro Ser Ala Gly Ala Gln Ser Pro Ala Ile Ile Asp Ser 
                165                 170                 175     


Asp Pro Val Asp Glu Glu Val Leu Met Ser Leu Val Val Glu Leu Gly 
            180                 185                 190         


Leu Asp Arg Ala Asn Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu 
        195                 200                 205             


Phe Asp Phe Thr Ala Asp Phe Pro Ser Ser Cys 
    210                 215                 


<210>  2212
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CITED2__Homo_sapiens__NP_001161860

<400>  2212

Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
1               5                   10                  15      


Thr Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
            20                  25                  30          


Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
        35                  40                  45              


Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
    50                  55                  60                  


Ala Thr Ser Gly Ile Arg His Ala Met Gly Pro Gly Thr Val Asn Gly 
65                  70                  75                  80  


Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                85                  90                  95      


Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
            100                 105                 110         


Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
        115                 120                 125             


Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
    130                 135                 140                 


Gln Met Asn Gly Thr Asn Gln His Phe Arg Asp Cys Asn Pro Lys His 
145                 150                 155                 160 


Ser Gly Gly Ser Ser Thr Pro Gly Gly Ser Gly Gly Ser Ser Thr Pro 
                165                 170                 175     


Gly Gly Ser Gly Ser Ser Ser Gly Gly Gly Ala Gly Ser Ser Asn Ser 
            180                 185                 190         


Gly Gly Gly Ser Gly Ser Gly Asn Met Pro Ala Ser Val Ala His Val 
        195                 200                 205             


Pro Ala Ala Met Leu Pro Pro Asn Val Ile Asp Thr Asp Phe Ile Asp 
    210                 215                 220                 


Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile 
225                 230                 235                 240 


Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met 
                245                 250                 255     


Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser Cys 
            260                 265                 270 


<210>  2213
<211>  2069
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIT__Homo_sapiens__NP_001193928

<400>  2213

Met Leu Lys Phe Lys Tyr Gly Ala Arg Asn Pro Leu Asp Ala Gly Ala 
1               5                   10                  15      


Ala Glu Pro Ile Ala Ser Arg Ala Ser Arg Leu Asn Leu Phe Phe Gln 
            20                  25                  30          


Gly Lys Pro Pro Phe Met Thr Gln Gln Gln Met Ser Pro Leu Ser Arg 
        35                  40                  45              


Glu Gly Ile Leu Asp Ala Leu Phe Val Leu Phe Glu Glu Cys Ser Gln 
    50                  55                  60                  


Pro Ala Leu Met Lys Ile Lys His Val Ser Asn Phe Val Arg Lys Tyr 
65                  70                  75                  80  


Ser Asp Thr Ile Ala Glu Leu Gln Glu Leu Gln Pro Ser Ala Lys Asp 
                85                  90                  95      


Phe Glu Val Arg Ser Leu Val Gly Cys Gly His Phe Ala Glu Val Gln 
            100                 105                 110         


Val Val Arg Glu Lys Ala Thr Gly Asp Ile Tyr Ala Met Lys Val Met 
        115                 120                 125             


Lys Lys Lys Ala Leu Leu Ala Gln Glu Gln Val Ser Phe Phe Glu Glu 
    130                 135                 140                 


Glu Arg Asn Ile Leu Ser Arg Ser Thr Ser Pro Trp Ile Pro Gln Leu 
145                 150                 155                 160 


Gln Tyr Ala Phe Gln Asp Lys Asn His Leu Tyr Leu Val Met Glu Tyr 
                165                 170                 175     


Gln Pro Gly Gly Asp Leu Leu Ser Leu Leu Asn Arg Tyr Glu Asp Gln 
            180                 185                 190         


Leu Asp Glu Asn Leu Ile Gln Phe Tyr Leu Ala Glu Leu Ile Leu Ala 
        195                 200                 205             


Val His Ser Val His Leu Met Gly Tyr Val His Arg Asp Ile Lys Pro 
    210                 215                 220                 


Glu Asn Ile Leu Val Asp Arg Thr Gly His Ile Lys Leu Val Asp Phe 
225                 230                 235                 240 


Gly Ser Ala Ala Lys Met Asn Ser Asn Lys Met Val Asn Ala Lys Leu 
                245                 250                 255     


Pro Ile Gly Thr Pro Asp Tyr Met Ala Pro Glu Val Leu Thr Val Met 
            260                 265                 270         


Asn Gly Asp Gly Lys Gly Thr Tyr Gly Leu Asp Cys Asp Trp Trp Ser 
        275                 280                 285             


Val Gly Val Ile Ala Tyr Glu Met Ile Tyr Gly Arg Ser Pro Phe Ala 
    290                 295                 300                 


Glu Gly Thr Ser Ala Arg Thr Phe Asn Asn Ile Met Asn Phe Gln Arg 
305                 310                 315                 320 


Phe Leu Lys Phe Pro Asp Asp Pro Lys Val Ser Ser Asp Phe Leu Asp 
                325                 330                 335     


Leu Ile Gln Ser Leu Leu Cys Gly Gln Lys Glu Arg Leu Lys Phe Glu 
            340                 345                 350         


Gly Leu Cys Cys His Pro Phe Phe Ser Lys Ile Asp Trp Asn Asn Ile 
        355                 360                 365             


Arg Asn Ser Pro Pro Pro Phe Val Pro Thr Leu Lys Ser Asp Asp Asp 
    370                 375                 380                 


Thr Ser Asn Phe Asp Glu Pro Glu Lys Asn Ser Trp Val Ser Ser Ser 
385                 390                 395                 400 


Pro Cys Gln Leu Ser Pro Ser Gly Phe Ser Gly Glu Glu Leu Pro Phe 
                405                 410                 415     


Val Gly Phe Ser Tyr Ser Lys Ala Leu Gly Ile Leu Gly Arg Ser Glu 
            420                 425                 430         


Ser Val Val Ser Gly Leu Asp Ser Pro Ala Lys Thr Ser Ser Met Glu 
        435                 440                 445             


Lys Lys Leu Leu Ile Lys Ser Lys Glu Leu Gln Asp Ser Gln Asp Lys 
    450                 455                 460                 


Cys His Lys Met Glu Gln Glu Met Thr Arg Leu His Arg Arg Val Ser 
465                 470                 475                 480 


Glu Val Glu Ala Val Leu Ser Gln Lys Glu Val Glu Leu Lys Ala Ser 
                485                 490                 495     


Glu Thr Gln Arg Ser Leu Leu Glu Gln Asp Leu Ala Thr Tyr Ile Thr 
            500                 505                 510         


Glu Cys Ser Ser Leu Lys Arg Ser Leu Glu Gln Ala Arg Met Glu Val 
        515                 520                 525             


Ser Gln Glu Asp Asp Lys Ala Leu Gln Leu Leu His Asp Ile Arg Glu 
    530                 535                 540                 


Gln Ser Arg Lys Leu Gln Glu Ile Lys Glu Gln Glu Tyr Gln Ala Gln 
545                 550                 555                 560 


Val Glu Glu Met Arg Leu Met Met Asn Gln Leu Glu Glu Asp Leu Val 
                565                 570                 575     


Ser Ala Arg Arg Arg Ser Asp Leu Tyr Glu Ser Glu Leu Arg Glu Ser 
            580                 585                 590         


Arg Leu Ala Ala Glu Glu Phe Lys Arg Lys Ala Thr Glu Cys Gln His 
        595                 600                 605             


Lys Leu Leu Lys Ala Lys Asp Gln Gly Lys Pro Glu Val Gly Glu Tyr 
    610                 615                 620                 


Ala Lys Leu Glu Lys Ile Asn Ala Glu Gln Gln Leu Lys Ile Gln Glu 
625                 630                 635                 640 


Leu Gln Glu Lys Leu Glu Lys Ala Val Lys Ala Ser Thr Glu Ala Thr 
                645                 650                 655     


Glu Leu Leu Gln Asn Ile Arg Gln Ala Lys Glu Arg Ala Glu Arg Glu 
            660                 665                 670         


Leu Glu Lys Leu Gln Asn Arg Glu Asp Ser Ser Glu Gly Ile Arg Lys 
        675                 680                 685             


Lys Leu Val Glu Ala Glu Glu Arg Arg His Ser Leu Glu Asn Lys Val 
    690                 695                 700                 


Lys Arg Leu Glu Thr Met Glu Arg Arg Glu Asn Arg Leu Lys Asp Asp 
705                 710                 715                 720 


Ile Gln Thr Lys Ser Gln Gln Ile Gln Gln Met Ala Asp Lys Ile Leu 
                725                 730                 735     


Glu Leu Glu Glu Lys His Arg Glu Ala Gln Val Ser Ala Gln His Leu 
            740                 745                 750         


Glu Val His Leu Lys Gln Lys Glu Gln His Tyr Glu Glu Lys Ile Lys 
        755                 760                 765             


Val Leu Asp Asn Gln Ile Lys Lys Asp Leu Ala Asp Lys Glu Thr Leu 
    770                 775                 780                 


Glu Asn Met Met Gln Arg His Glu Glu Glu Ala His Glu Lys Gly Lys 
785                 790                 795                 800 


Ile Leu Ser Glu Gln Lys Ala Met Ile Asn Ala Met Asp Ser Lys Ile 
                805                 810                 815     


Arg Ser Leu Glu Gln Arg Ile Val Glu Leu Ser Glu Ala Asn Lys Leu 
            820                 825                 830         


Ala Ala Asn Ser Ser Leu Phe Thr Gln Arg Asn Met Lys Ala Gln Glu 
        835                 840                 845             


Glu Met Ile Ser Glu Leu Arg Gln Gln Lys Phe Tyr Leu Glu Thr Gln 
    850                 855                 860                 


Ala Gly Lys Leu Glu Ala Gln Asn Arg Lys Leu Glu Glu Gln Leu Glu 
865                 870                 875                 880 


Lys Ile Ser His Gln Asp His Ser Asp Lys Asn Arg Leu Leu Glu Leu 
                885                 890                 895     


Glu Thr Arg Leu Arg Glu Val Ser Leu Glu His Glu Glu Gln Lys Leu 
            900                 905                 910         


Glu Leu Lys Arg Gln Leu Thr Glu Leu Gln Leu Ser Leu Gln Glu Arg 
        915                 920                 925             


Glu Ser Gln Leu Thr Ala Leu Gln Ala Ala Arg Ala Ala Leu Glu Ser 
    930                 935                 940                 


Gln Leu Arg Gln Ala Lys Thr Glu Leu Glu Glu Thr Thr Ala Glu Ala 
945                 950                 955                 960 


Glu Glu Glu Ile Gln Ala Leu Thr Ala His Arg Asp Glu Ile Gln Arg 
                965                 970                 975     


Lys Phe Asp Ala Leu Arg Asn Ser Cys Thr Val Ile Thr Asp Leu Glu 
            980                 985                 990         


Glu Gln Leu Asn Gln Leu Thr Glu  Asp Asn Ala Glu Leu  Asn Asn Gln 
        995                 1000                 1005             


Asn Phe  Tyr Leu Ser Lys Gln  Leu Asp Glu Ala Ser  Gly Ala Asn 
    1010                 1015                 1020             


Asp Glu  Ile Val Gln Leu Arg  Ser Glu Val Asp His  Leu Arg Arg 
    1025                 1030                 1035             


Glu Ile  Thr Glu Arg Glu Met  Gln Leu Thr Ser Gln  Lys Gln Thr 
    1040                 1045                 1050             


Met Glu  Ala Leu Lys Thr Thr  Cys Thr Met Leu Glu  Glu Gln Val 
    1055                 1060                 1065             


Met Asp  Leu Glu Ala Leu Asn  Asp Glu Leu Leu Glu  Lys Glu Arg 
    1070                 1075                 1080             


Gln Trp  Glu Ala Trp Arg Ser  Val Leu Gly Asp Glu  Lys Ser Gln 
    1085                 1090                 1095             


Phe Glu  Cys Arg Val Arg Glu  Leu Gln Arg Met Leu  Asp Thr Glu 
    1100                 1105                 1110             


Lys Gln  Ser Arg Ala Arg Ala  Asp Gln Arg Ile Thr  Glu Ser Arg 
    1115                 1120                 1125             


Gln Val  Val Glu Leu Ala Val  Lys Glu His Lys Ala  Glu Ile Leu 
    1130                 1135                 1140             


Ala Leu  Gln Gln Ala Leu Lys  Glu Gln Lys Leu Lys  Ala Glu Ser 
    1145                 1150                 1155             


Leu Ser  Asp Lys Leu Asn Asp  Leu Glu Lys Lys His  Ala Met Leu 
    1160                 1165                 1170             


Glu Met  Asn Ala Arg Ser Leu  Gln Gln Lys Leu Glu  Thr Glu Arg 
    1175                 1180                 1185             


Glu Leu  Lys Gln Arg Leu Leu  Glu Glu Gln Ala Lys  Leu Gln Gln 
    1190                 1195                 1200             


Gln Met  Asp Leu Gln Lys Asn  His Ile Phe Arg Leu  Thr Gln Gly 
    1205                 1210                 1215             


Leu Gln  Glu Ala Leu Asp Arg  Ala Asp Leu Leu Lys  Thr Glu Arg 
    1220                 1225                 1230             


Ser Asp  Leu Glu Tyr Gln Leu  Glu Asn Ile Gln Val  Leu Tyr Ser 
    1235                 1240                 1245             


His Glu  Lys Val Lys Met Glu  Gly Thr Ile Ser Gln  Gln Thr Lys 
    1250                 1255                 1260             


Leu Ile  Asp Phe Leu Gln Ala  Lys Met Asp Gln Pro  Ala Lys Lys 
    1265                 1270                 1275             


Lys Lys  Gly Leu Phe Ser Arg  Arg Lys Glu Asp Pro  Ala Leu Pro 
    1280                 1285                 1290             


Thr Gln  Val Pro Leu Gln Tyr  Asn Glu Leu Lys Leu  Ala Leu Glu 
    1295                 1300                 1305             


Lys Glu  Lys Ala Arg Cys Ala  Glu Leu Glu Glu Ala  Leu Gln Lys 
    1310                 1315                 1320             


Thr Arg  Ile Glu Leu Arg Ser  Ala Arg Glu Glu Ala  Ala His Arg 
    1325                 1330                 1335             


Lys Ala  Thr Asp His Pro His  Pro Ser Thr Pro Ala  Thr Ala Arg 
    1340                 1345                 1350             


Gln Gln  Ile Ala Met Ser Ala  Ile Val Arg Ser Pro  Glu His Gln 
    1355                 1360                 1365             


Pro Ser  Ala Met Ser Leu Leu  Ala Pro Pro Ser Ser  Arg Arg Lys 
    1370                 1375                 1380             


Glu Ser  Ser Thr Pro Glu Glu  Phe Ser Arg Arg Leu  Lys Glu Arg 
    1385                 1390                 1395             


Met His  His Asn Ile Pro His  Arg Phe Asn Val Gly  Leu Asn Met 
    1400                 1405                 1410             


Arg Ala  Thr Lys Cys Ala Val  Cys Leu Asp Thr Val  His Phe Gly 
    1415                 1420                 1425             


Arg Gln  Ala Ser Lys Cys Leu  Glu Cys Gln Val Met  Cys His Pro 
    1430                 1435                 1440             


Lys Cys  Ser Thr Cys Leu Pro  Ala Thr Cys Gly Leu  Pro Ala Glu 
    1445                 1450                 1455             


Tyr Ala  Thr His Phe Thr Glu  Ala Phe Cys Arg Asp  Lys Met Asn 
    1460                 1465                 1470             


Ser Pro  Gly Leu Gln Thr Lys  Glu Pro Ser Ser Ser  Leu His Leu 
    1475                 1480                 1485             


Glu Gly  Trp Met Lys Val Pro  Arg Asn Asn Lys Arg  Gly Gln Gln 
    1490                 1495                 1500             


Gly Trp  Asp Arg Lys Tyr Ile  Val Leu Glu Gly Ser  Lys Val Leu 
    1505                 1510                 1515             


Ile Tyr  Asp Asn Glu Ala Arg  Glu Ala Gly Gln Arg  Pro Val Glu 
    1520                 1525                 1530             


Glu Phe  Glu Leu Cys Leu Pro  Asp Gly Asp Val Ser  Ile His Gly 
    1535                 1540                 1545             


Ala Val  Gly Ala Ser Glu Leu  Ala Asn Thr Ala Lys  Ala Asp Val 
    1550                 1555                 1560             


Pro Tyr  Ile Leu Lys Met Glu  Ser His Pro His Thr  Thr Cys Trp 
    1565                 1570                 1575             


Pro Gly  Arg Thr Leu Tyr Leu  Leu Ala Pro Ser Phe  Pro Asp Lys 
    1580                 1585                 1590             


Gln Arg  Trp Val Thr Ala Leu  Glu Ser Val Val Ala  Gly Gly Arg 
    1595                 1600                 1605             


Val Ser  Arg Glu Lys Ala Glu  Ala Asp Ala Lys Leu  Leu Gly Asn 
    1610                 1615                 1620             


Ser Leu  Leu Lys Leu Glu Gly  Asp Asp Arg Leu Asp  Met Asn Cys 
    1625                 1630                 1635             


Thr Leu  Pro Phe Ser Asp Gln  Val Val Leu Val Gly  Thr Glu Glu 
    1640                 1645                 1650             


Gly Leu  Tyr Ala Leu Asn Val  Leu Lys Asn Ser Leu  Thr His Val 
    1655                 1660                 1665             


Pro Gly  Ile Gly Ala Val Phe  Gln Ile Tyr Ile Ile  Lys Asp Leu 
    1670                 1675                 1680             


Glu Lys  Leu Leu Met Ile Ala  Gly Glu Glu Arg Ala  Leu Cys Leu 
    1685                 1690                 1695             


Val Asp  Val Lys Lys Val Lys  Gln Ser Leu Ala Gln  Ser His Leu 
    1700                 1705                 1710             


Pro Ala  Gln Pro Asp Ile Ser  Pro Asn Ile Phe Glu  Ala Val Lys 
    1715                 1720                 1725             


Gly Cys  His Leu Phe Gly Ala  Gly Lys Ile Glu Asn  Gly Leu Cys 
    1730                 1735                 1740             


Ile Cys  Ala Ala Met Pro Ser  Lys Val Val Ile Leu  Arg Tyr Asn 
    1745                 1750                 1755             


Glu Asn  Leu Ser Lys Tyr Cys  Ile Arg Lys Glu Ile  Glu Thr Ser 
    1760                 1765                 1770             


Glu Pro  Cys Ser Cys Ile His  Phe Thr Asn Tyr Ser  Ile Leu Ile 
    1775                 1780                 1785             


Gly Thr  Asn Lys Phe Tyr Glu  Ile Asp Met Lys Gln  Tyr Thr Leu 
    1790                 1795                 1800             


Glu Glu  Phe Leu Asp Lys Asn  Asp His Ser Leu Ala  Pro Ala Val 
    1805                 1810                 1815             


Phe Ala  Ala Ser Ser Asn Ser  Phe Pro Val Ser Ile  Val Gln Val 
    1820                 1825                 1830             


Asn Ser  Ala Gly Gln Arg Glu  Glu Tyr Leu Leu Cys  Phe His Glu 
    1835                 1840                 1845             


Phe Gly  Val Phe Val Asp Ser  Tyr Gly Arg Arg Ser  Arg Thr Asp 
    1850                 1855                 1860             


Asp Leu  Lys Trp Ser Arg Leu  Pro Leu Ala Phe Ala  Tyr Arg Glu 
    1865                 1870                 1875             


Pro Tyr  Leu Phe Val Thr His  Phe Asn Ser Leu Glu  Val Ile Glu 
    1880                 1885                 1890             


Ile Gln  Ala Arg Ser Ser Ala  Gly Thr Pro Ala Arg  Ala Tyr Leu 
    1895                 1900                 1905             


Asp Ile  Pro Asn Pro Arg Tyr  Leu Gly Pro Ala Ile  Ser Ser Gly 
    1910                 1915                 1920             


Ala Ile  Tyr Leu Ala Ser Ser  Tyr Gln Asp Lys Leu  Arg Val Ile 
    1925                 1930                 1935             


Cys Cys  Lys Gly Asn Leu Val  Lys Glu Ser Gly Thr  Glu His His 
    1940                 1945                 1950             


Arg Gly  Pro Ser Thr Ser Arg  Ser Ser Pro Asn Lys  Arg Gly Pro 
    1955                 1960                 1965             


Pro Thr  Tyr Asn Glu His Ile  Thr Lys Arg Val Ala  Ser Ser Pro 
    1970                 1975                 1980             


Ala Pro  Pro Glu Gly Pro Ser  His Pro Arg Glu Pro  Ser Thr Pro 
    1985                 1990                 1995             


His Arg  Tyr Arg Glu Gly Arg  Thr Glu Leu Arg Arg  Asp Lys Ser 
    2000                 2005                 2010             


Pro Gly  Arg Pro Leu Glu Arg  Glu Lys Ser Pro Gly  Arg Met Leu 
    2015                 2020                 2025             


Ser Thr  Arg Arg Glu Arg Ser  Pro Gly Arg Leu Phe  Glu Asp Ser 
    2030                 2035                 2040             


Ser Arg  Gly Arg Leu Pro Ala  Gly Ala Val Arg Thr  Pro Leu Ser 
    2045                 2050                 2055             


Gln Val  Asn Lys Val Trp Asp  Gln Ser Ser Val 
    2060                 2065                 


<210>  2214
<211>  818
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIZ1__Homo_sapiens__NP_001124490

<400>  2214

Met Phe Ser Gln Gln Gln Gln Gln Gln Leu Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Leu Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln 
            20                  25                  30          


Gln Gln Leu Leu Gln Leu Gln Gln Leu Leu Gln Gln Ser Pro Pro Gln 
        35                  40                  45              


Ala Pro Leu Pro Met Ala Val Ser Arg Gly Leu Pro Pro Gln Gln Pro 
    50                  55                  60                  


Gln Gln Pro Leu Leu Asn Leu Gln Gly Thr Asn Ser Ala Ser Leu Leu 
65                  70                  75                  80  


Asn Gly Ser Met Leu Gln Arg Ala Leu Leu Leu Gln Gln Leu Gln Gly 
                85                  90                  95      


Asn Leu Arg Gly Tyr Gly Met Ala Ser Pro Gly Leu Ala Ala Pro Ser 
            100                 105                 110         


Leu Thr Pro Pro Gln Leu Ala Thr Pro Asn Leu Gln Gln Phe Phe Pro 
        115                 120                 125             


Gln Ala Thr Arg Gln Ser Leu Leu Gly Pro Pro Pro Val Gly Val Pro 
    130                 135                 140                 


Met Asn Pro Ser Gln Phe Asn Leu Ser Gly Arg Asn Pro Gln Lys Gln 
145                 150                 155                 160 


Ala Arg Thr Ser Ser Ser Thr Thr Pro Asn Arg Lys Asp Ser Ser Ser 
                165                 170                 175     


Gln Thr Met Pro Val Glu Asp Lys Ser Asp Pro Pro Glu Gly Ser Glu 
            180                 185                 190         


Glu Ala Ala Glu Pro Arg Met Asp Thr Pro Glu Asp Gln Asp Leu Pro 
        195                 200                 205             


Pro Cys Pro Glu Asp Ile Ala Lys Glu Lys Arg Thr Pro Ala Pro Glu 
    210                 215                 220                 


Pro Glu Pro Cys Glu Ala Ser Glu Leu Pro Ala Lys Arg Leu Arg Ser 
225                 230                 235                 240 


Ser Glu Glu Pro Thr Glu Lys Glu Pro Pro Gly Gln Leu Gln Val Lys 
                245                 250                 255     


Ala Gln Pro Gln Ala Arg Met Thr Val Pro Lys Gln Thr Gln Thr Pro 
            260                 265                 270         


Asp Leu Leu Pro Glu Ala Leu Glu Ala Gln Val Leu Pro Arg Phe Gln 
        275                 280                 285             


Pro Arg Val Leu Gln Val Gln Ala Gln Val Gln Ser Gln Thr Gln Pro 
    290                 295                 300                 


Arg Ile Pro Ser Thr Asp Thr Gln Val Gln Pro Lys Leu Gln Lys Gln 
305                 310                 315                 320 


Ala Gln Thr Gln Thr Ser Pro Glu His Leu Val Leu Gln Gln Lys Gln 
                325                 330                 335     


Val Gln Pro Gln Leu Gln Gln Glu Ala Glu Pro Gln Lys Gln Val Gln 
            340                 345                 350         


Pro Gln Val His Thr Gln Ala Gln Pro Ser Val Gln Pro Gln Glu His 
        355                 360                 365             


Pro Pro Ala Gln Val Ser Val Gln Pro Pro Glu Gln Thr His Glu Gln 
    370                 375                 380                 


Pro His Thr Gln Pro Gln Val Ser Leu Leu Ala Pro Glu Gln Thr Pro 
385                 390                 395                 400 


Val Val Val His Val Cys Gly Leu Glu Met Pro Pro Asp Ala Val Glu 
                405                 410                 415     


Ala Gly Gly Gly Met Glu Lys Thr Leu Pro Glu Pro Val Gly Thr Gln 
            420                 425                 430         


Val Ser Met Glu Glu Ile Gln Asn Glu Ser Ala Cys Gly Leu Asp Val 
        435                 440                 445             


Gly Glu Cys Glu Asn Arg Ala Arg Glu Met Pro Gly Val Trp Gly Ala 
    450                 455                 460                 


Gly Gly Ser Leu Lys Val Thr Ile Leu Gln Ser Ser Asp Ser Arg Ala 
465                 470                 475                 480 


Phe Ser Thr Val Pro Leu Thr Pro Val Pro Arg Pro Ser Asp Ser Val 
                485                 490                 495     


Ser Ser Thr Pro Ala Ala Thr Ser Thr Pro Ser Lys Gln Ala Leu Gln 
            500                 505                 510         


Phe Phe Cys Tyr Ile Cys Lys Ala Ser Cys Ser Ser Gln Gln Glu Phe 
        515                 520                 525             


Gln Asp His Met Ser Glu Pro Gln His Gln Gln Arg Leu Gly Glu Ile 
    530                 535                 540                 


Gln His Met Ser Gln Ala Cys Leu Leu Ser Leu Leu Pro Val Pro Arg 
545                 550                 555                 560 


Asp Val Leu Glu Thr Glu Asp Glu Glu Pro Pro Pro Arg Arg Trp Cys 
                565                 570                 575     


Asn Thr Cys Gln Leu Tyr Tyr Met Gly Asp Leu Ile Gln His Arg Arg 
            580                 585                 590         


Thr Gln Asp His Lys Ile Ala Lys Gln Ser Leu Arg Pro Phe Cys Thr 
        595                 600                 605             


Val Cys Asn Arg Tyr Phe Lys Thr Pro Arg Lys Phe Val Glu His Val 
    610                 615                 620                 


Lys Ser Gln Gly His Lys Asp Lys Ala Lys Glu Leu Lys Ser Leu Glu 
625                 630                 635                 640 


Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala 
                645                 650                 655     


Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp 
            660                 665                 670         


Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg Ser 
        675                 680                 685             


Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro 
    690                 695                 700                 


Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro Val Met Gly Tyr Ile 
705                 710                 715                 720 


Cys Arg Ile Cys His Lys Phe Tyr His Ser Asn Ser Gly Ala Gln Leu 
                725                 730                 735     


Ser His Cys Lys Ser Leu Gly His Phe Glu Asn Leu Gln Lys Tyr Lys 
            740                 745                 750         


Ala Ala Lys Asn Pro Ser Pro Thr Thr Arg Pro Val Ser Arg Arg Cys 
        755                 760                 765             


Ala Ile Asn Ala Arg Asn Ala Leu Thr Ala Leu Phe Thr Ser Ser Gly 
    770                 775                 780                 


Arg Pro Pro Ser Gln Pro Asn Thr Gln Asp Lys Thr Pro Ser Lys Val 
785                 790                 795                 800 


Thr Ala Arg Pro Ser Gln Pro Pro Leu Pro Arg Arg Ser Thr Arg Leu 
                805                 810                 815     


Lys Thr 
        


<210>  2215
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKAP2__Homo_sapiens__NP_001091995

<400>  2215

Met Ser Thr Pro Ala Val Pro Gln Asp Leu Gln Leu Pro Pro Ser Gln 
1               5                   10                  15      


Arg Ala Gln Ser Ala Phe Lys Glu Gln Arg Arg Gln Lys Leu Lys Glu 
            20                  25                  30          


His Leu Leu Arg Arg Lys Thr Leu Phe Ala Tyr Lys Gln Glu Asn Glu 
        35                  40                  45              


Met Leu Ser Ser Ser Arg Asp Gln Arg Val Val Thr Ser Glu Asp Gln 
    50                  55                  60                  


Val Gln Glu Gly Thr Lys Val Leu Lys Leu Lys Thr Lys Met Ala Asp 
65                  70                  75                  80  


Lys Glu Asn Met Lys Arg Pro Ala Glu Ser Lys Asn Asn Thr Val Val 
                85                  90                  95      


Gly Lys His Cys Ile Pro Leu Lys Pro Ser Asn Glu Leu Thr Asn Ser 
            100                 105                 110         


Thr Val Val Ile Asp Thr His Lys Pro Lys Asp Ser Asn Gln Thr Pro 
        115                 120                 125             


His Leu Leu Leu Thr Glu Asp Asp Pro Gln Ser Gln His Met Thr Leu 
    130                 135                 140                 


Ser Gln Ala Phe His Leu Lys Asn Asn Ser Lys Lys Lys Gln Met Thr 
145                 150                 155                 160 


Thr Glu Lys Gln Lys Gln Asp Ala Asn Met Pro Lys Lys Pro Val Leu 
                165                 170                 175     


Gly Ser Tyr Arg Gly Gln Ile Val Gln Ser Lys Ile Asn Ser Phe Arg 
            180                 185                 190         


Lys Pro Leu Gln Val Lys Asp Glu Ser Ser Ala Ala Thr Lys Lys Leu 
        195                 200                 205             


Ser Ala Thr Ile Pro Lys Ala Thr Lys Pro Gln Pro Val Asn Thr Ser 
    210                 215                 220                 


Ser Val Thr Val Lys Ser Asn Arg Ser Ser Asn Met Thr Ala Thr Thr 
225                 230                 235                 240 


Lys Phe Val Ser Thr Thr Ser Gln Asn Thr Gln Leu Val Arg Pro Pro 
                245                 250                 255     


Ile Arg Ser His His Ser Asn Thr Arg Asp Thr Val Lys Gln Gly Ile 
            260                 265                 270         


Ser Arg Thr Ser Ala Asn Val Thr Ile Arg Lys Gly Pro His Glu Lys 
        275                 280                 285             


Glu Leu Leu Gln Ser Lys Thr Ala Leu Ser Ser Val Lys Thr Ser Ser 
    290                 295                 300                 


Ser Gln Gly Ile Ile Arg Asn Lys Thr Leu Ser Arg Ser Ile Ala Ser 
305                 310                 315                 320 


Glu Val Ile Ala Arg Pro Ala Ser Leu Ser Asn Asp Lys Leu Met Glu 
                325                 330                 335     


Lys Ser Glu Pro Val Asp Gln Arg Arg His Thr Ala Gly Lys Ala Ile 
            340                 345                 350         


Val Asp Ser Arg Ser Ala Gln Pro Lys Glu Thr Ser Glu Glu Arg Lys 
        355                 360                 365             


Ala Arg Leu Ser Glu Trp Lys Ala Gly Lys Gly Arg Val Leu Lys Arg 
    370                 375                 380                 


Pro Pro Asn Ser Val Val Thr Gln His Glu Pro Ala Gly Gln Asn Glu 
385                 390                 395                 400 


Lys Pro Val Gly Ser Phe Trp Thr Thr Met Ala Glu Glu Asp Glu Gln 
                405                 410                 415     


Arg Leu Phe Thr Glu Lys Val Asn Asn Thr Phe Ser Glu Cys Leu Asn 
            420                 425                 430         


Leu Ile Asn Glu Gly Cys Pro Lys Glu Asp Ile Leu Val Thr Leu Asn 
        435                 440                 445             


Asp Leu Ile Lys Asn Ile Pro Asp Ala Lys Lys Leu Val Lys Tyr Trp 
    450                 455                 460                 


Ile Cys Leu Ala Leu Ile Glu Pro Ile Thr Ser Pro Ile Glu Asn Ile 
465                 470                 475                 480 


Ile Ala Ile Tyr Glu Lys Ala Ile Leu Ala Gly Ala Gln Pro Ile Glu 
                485                 490                 495     


Glu Met Arg His Thr Ile Val Asp Ile Leu Thr Met Lys Ser Gln Glu 
            500                 505                 510         


Lys Ala Asn Leu Gly Glu Asn Met Glu Lys Ser Cys Ala Ser Lys Glu 
        515                 520                 525             


Glu Val Lys Glu Val Ser Ile Glu Asp Thr Gly Val Asp Val Asp Pro 
    530                 535                 540                 


Glu Lys Leu Glu Met Glu Ser Lys Leu His Arg Asn Leu Leu Phe Gln 
545                 550                 555                 560 


Asp Cys Glu Lys Glu Gln Asp Asn Lys Thr Lys Asp Pro Thr His Asp 
                565                 570                 575     


Val Lys Thr Pro Asn Thr Glu Thr Arg Thr Ser Cys Leu Ile Lys Tyr 
            580                 585                 590         


Asn Val Ser Thr Thr Pro Tyr Leu Gln Ser Val Lys Lys Lys Val Gln 
        595                 600                 605             


Phe Asp Gly Thr Asn Ser Ala Phe Lys Glu Leu Lys Phe Leu Thr Pro 
    610                 615                 620                 


Val Arg Arg Ser Arg Arg Leu Gln Glu Lys Thr Ser Lys Leu Pro Asp 
625                 630                 635                 640 


Met Leu Lys Asp His Tyr Pro Cys Val Ser Ser Leu Glu Gln Leu Thr 
                645                 650                 655     


Glu Leu Gly Arg Glu Thr Asp Ala Phe Val Cys Arg Pro Asn Ala Ala 
            660                 665                 670         


Leu Cys Arg Val Tyr Tyr Glu Ala Asp Thr Thr 
        675                 680             


<210>  2216
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKAP2L__Homo_sapiens__NP_689728

<400>  2216

Met Val Gly Pro Gly Pro Thr Ala Ala Ala Ala Val Glu Glu Arg Gln 
1               5                   10                  15      


Arg Lys Leu Gln Glu Tyr Leu Ala Ala Lys Gly Lys Leu Lys Ser Gln 
            20                  25                  30          


Asn Thr Lys Pro Tyr Leu Lys Ser Lys Asn Asn Cys Gln Asn Gln Pro 
        35                  40                  45              


Pro Ser Lys Ser Thr Ile Arg Pro Lys Asn Asp Val Thr Asn His Val 
    50                  55                  60                  


Val Leu Pro Val Lys Pro Lys Arg Ser Ile Ser Ile Lys Leu Gln Pro 
65                  70                  75                  80  


Arg Pro Pro Asn Thr Ala Gly Ser Gln Lys Pro Lys Leu Glu Pro Pro 
                85                  90                  95      


Lys Leu Leu Gly Lys Arg Leu Thr Ser Glu Cys Val Ser Ser Asn Pro 
            100                 105                 110         


Tyr Ser Lys Pro Ser Ser Lys Ser Phe Gln Gln Cys Glu Ala Gly Ser 
        115                 120                 125             


Ser Thr Thr Gly Glu Leu Ser Arg Lys Pro Val Gly Ser Leu Asn Ile 
    130                 135                 140                 


Glu Gln Leu Lys Thr Thr Lys Gln Gln Leu Thr Asp Gln Gly Asn Gly 
145                 150                 155                 160 


Lys Cys Ile Asp Phe Met Asn Asn Ile His Val Glu Asn Glu Ser Leu 
                165                 170                 175     


Asp Asn Phe Leu Lys Glu Thr Asn Lys Glu Asn Leu Leu Asp Ile Leu 
            180                 185                 190         


Thr Glu Pro Glu Arg Lys Pro Asp Pro Lys Leu Tyr Thr Arg Ser Lys 
        195                 200                 205             


Pro Lys Thr Asp Ser Tyr Asn Gln Thr Lys Asn Ser Leu Val Pro Lys 
    210                 215                 220                 


Gln Ala Leu Gly Lys Ser Ser Val Asn Ser Ala Val Leu Lys Asp Arg 
225                 230                 235                 240 


Val Asn Lys Gln Phe Val Gly Glu Thr Gln Ser Arg Thr Phe Pro Val 
                245                 250                 255     


Lys Ser Gln Gln Leu Ser Arg Gly Ala Asp Leu Ala Arg Pro Gly Val 
            260                 265                 270         


Lys Pro Ser Arg Thr Val Pro Ser His Phe Ile Arg Thr Leu Ser Lys 
        275                 280                 285             


Val Gln Ser Ser Lys Lys Pro Val Val Lys Asn Ile Lys Asp Ile Lys 
    290                 295                 300                 


Val Asn Arg Ser Gln Tyr Glu Arg Pro Asn Glu Thr Lys Ile Arg Ser 
305                 310                 315                 320 


Tyr Pro Val Thr Glu Gln Arg Val Lys His Thr Lys Pro Arg Thr Tyr 
                325                 330                 335     


Pro Ser Leu Leu Gln Gly Glu Tyr Asn Asn Arg His Pro Asn Ile Lys 
            340                 345                 350         


Gln Asp Gln Lys Ser Ser Gln Val Cys Ile Pro Gln Thr Ser Cys Val 
        355                 360                 365             


Leu Gln Lys Ser Lys Ala Ile Ser Gln Arg Pro Asn Leu Thr Val Gly 
    370                 375                 380                 


Arg Phe Asn Ser Ala Ile Pro Ser Thr Pro Ser Ile Arg Pro Asn Gly 
385                 390                 395                 400 


Thr Ser Gly Asn Lys His Asn Asn Asn Gly Phe Gln Gln Lys Ala Gln 
                405                 410                 415     


Thr Leu Asp Ser Lys Leu Lys Lys Ala Val Pro Gln Asn His Phe Leu 
            420                 425                 430         


Asn Lys Thr Ala Pro Lys Thr Gln Ala Asp Val Thr Thr Val Asn Gly 
        435                 440                 445             


Thr Gln Thr Asn Pro Asn Ile Lys Lys Lys Ala Thr Ala Glu Asp Arg 
    450                 455                 460                 


Arg Lys Gln Leu Glu Glu Trp Gln Lys Ser Lys Gly Lys Thr Tyr Lys 
465                 470                 475                 480 


Arg Pro Pro Met Glu Leu Lys Thr Lys Arg Lys Val Ile Lys Glu Met 
                485                 490                 495     


Asn Ile Ser Phe Trp Lys Ser Ile Glu Lys Glu Glu Glu Glu Lys Lys 
            500                 505                 510         


Ala Gln Leu Glu Leu Ser Ser Lys Ile Asn Asn Thr Leu Thr Glu Cys 
        515                 520                 525             


Leu Asn Leu Ile Glu Gly Gly Val Pro Ser Asn Glu Ile Leu Asn Ile 
    530                 535                 540                 


Leu Ser Ser Ile Pro Glu Ala Glu Lys Phe Ala Lys Phe Trp Ile Cys 
545                 550                 555                 560 


Lys Ala Lys Leu Leu Ala Ser Lys Gly Thr Phe Asp Val Ile Gly Leu 
                565                 570                 575     


Tyr Glu Glu Ala Ile Lys Asn Gly Ala Thr Pro Ile Gln Glu Leu Arg 
            580                 585                 590         


Lys Val Val Leu Asn Ile Leu Gln Asp Ser Asn Arg Thr Thr Glu Gly 
        595                 600                 605             


Ile Thr Ser Asp Ser Leu Val Ala Glu Thr Ser Ile Thr Ser Val Glu 
    610                 615                 620                 


Glu Leu Ala Lys Lys Met Glu Ser Val Lys Ser Cys Leu Ser Pro Lys 
625                 630                 635                 640 


Glu Arg Glu Gln Val Thr Ala Thr Pro Arg Ile Ala Lys Ala Glu Gln 
                645                 650                 655     


His Asn Tyr Pro Gly Ile Lys Leu Gln Ile Gly Pro Ile Pro Arg Ile 
            660                 665                 670         


Asn Gly Met Pro Glu Val Gln Asp Met Lys Phe Ile Thr Pro Val Arg 
        675                 680                 685             


Arg Ser Ser Arg Ile Glu Arg Ala Val Ser Arg Tyr Pro Glu Met Leu 
    690                 695                 700                 


Gln Glu His Asp Leu Val Val Ala Ser Leu Asp Glu Leu Leu Glu Val 
705                 710                 715                 720 


Glu Glu Thr Lys Cys Phe Ile Phe Arg Arg Asn Glu Ala Leu Pro Val 
                725                 730                 735     


Thr Leu Gly Phe Gln Thr Pro Glu Ser 
            740                 745 


<210>  2217
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKAP4__Homo_sapiens__NP_006816

<400>  2217

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp 
    450                 455                 460                 


Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu 
465                 470                 475                 480 


Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu 
                485                 490                 495     


Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr 
            500                 505                 510         


Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp 
        515                 520                 525             


Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser 
    530                 535                 540                 


Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu 
545                 550                 555                 560 


Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser 
                565                 570                 575     


Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe 
            580                 585                 590         


Val Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600         


<210>  2218
<211>  2032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKAP5__Homo_sapiens__NP_001008938

<400>  2218

Met Gly Asp Asp Ser Glu Trp Leu Lys Leu Pro Val Asp Gln Lys Cys 
1               5                   10                  15      


Glu His Lys Leu Trp Lys Ala Arg Leu Ser Gly Tyr Glu Glu Ala Leu 
            20                  25                  30          


Lys Ile Phe Gln Lys Ile Lys Asp Glu Lys Ser Pro Glu Trp Ser Lys 
        35                  40                  45              


Phe Leu Gly Leu Ile Lys Lys Phe Val Thr Asp Ser Asn Ala Val Val 
    50                  55                  60                  


Gln Leu Lys Gly Leu Glu Ala Ala Leu Val Tyr Val Glu Asn Ala His 
65                  70                  75                  80  


Val Ala Gly Lys Thr Thr Gly Glu Val Val Ser Gly Val Val Ser Lys 
                85                  90                  95      


Val Phe Asn Gln Pro Lys Ala Lys Ala Lys Glu Leu Gly Ile Glu Ile 
            100                 105                 110         


Cys Leu Met Tyr Ile Glu Ile Glu Lys Gly Glu Ala Val Gln Glu Glu 
        115                 120                 125             


Leu Leu Lys Gly Leu Asp Asn Lys Asn Pro Lys Ile Ile Val Ala Cys 
    130                 135                 140                 


Ile Glu Thr Leu Arg Lys Ala Leu Ser Glu Phe Gly Ser Lys Ile Ile 
145                 150                 155                 160 


Leu Leu Lys Pro Ile Ile Lys Val Leu Pro Lys Leu Phe Glu Ser Arg 
                165                 170                 175     


Glu Lys Ala Val Arg Asp Glu Ala Lys Leu Ile Ala Val Glu Ile Tyr 
            180                 185                 190         


Arg Trp Ile Arg Asp Ala Leu Arg Pro Pro Leu Gln Asn Ile Asn Ser 
        195                 200                 205             


Val Gln Leu Lys Glu Leu Glu Glu Glu Trp Val Lys Leu Pro Thr Ser 
    210                 215                 220                 


Ala Pro Arg Pro Thr Arg Phe Leu Arg Ser Gln Gln Glu Leu Glu Ala 
225                 230                 235                 240 


Lys Leu Glu Gln Gln Gln Ser Ala Gly Gly Asp Ala Glu Gly Gly Gly 
                245                 250                 255     


Asp Asp Gly Asp Glu Val Pro Gln Ile Asp Ala Tyr Glu Leu Leu Glu 
            260                 265                 270         


Ala Val Glu Ile Leu Ser Lys Leu Pro Lys Asp Phe Tyr Asp Lys Ile 
        275                 280                 285             


Glu Ala Lys Lys Trp Gln Glu Arg Lys Glu Ala Leu Glu Ser Val Glu 
    290                 295                 300                 


Val Leu Ile Lys Asn Pro Lys Leu Glu Ala Gly Asp Tyr Ala Asp Leu 
305                 310                 315                 320 


Val Lys Ala Leu Lys Lys Val Val Gly Lys Asp Thr Asn Val Met Leu 
                325                 330                 335     


Val Ala Leu Ala Ala Lys Cys Leu Thr Gly Leu Ala Val Gly Leu Arg 
            340                 345                 350         


Lys Lys Phe Gly Gln Tyr Ala Gly His Val Val Pro Thr Ile Leu Glu 
        355                 360                 365             


Lys Phe Lys Glu Lys Lys Pro Gln Val Val Gln Ala Leu Gln Glu Ala 
    370                 375                 380                 


Ile Asp Ala Ile Phe Leu Thr Thr Thr Leu Gln Asn Ile Ser Glu Asp 
385                 390                 395                 400 


Val Leu Ala Val Met Asp Asn Lys Asn Pro Thr Ile Lys Gln Gln Thr 
                405                 410                 415     


Ser Leu Phe Ile Ala Arg Ser Phe Arg His Cys Thr Ala Ser Thr Leu 
            420                 425                 430         


Pro Lys Ser Leu Leu Lys Pro Phe Cys Ala Ala Leu Leu Lys His Ile 
        435                 440                 445             


Asn Asp Ser Ala Pro Glu Val Arg Asp Ala Ala Phe Glu Ala Leu Gly 
    450                 455                 460                 


Thr Ala Leu Lys Val Val Gly Glu Lys Ala Val Asn Pro Phe Leu Ala 
465                 470                 475                 480 


Asp Val Asp Lys Leu Lys Leu Asp Lys Ile Lys Glu Cys Ser Glu Lys 
                485                 490                 495     


Val Glu Leu Ile His Gly Lys Lys Ala Gly Leu Ala Ala Asp Lys Lys 
            500                 505                 510         


Glu Phe Lys Pro Leu Pro Gly Arg Thr Ala Ala Ser Gly Ala Ala Gly 
        515                 520                 525             


Asp Lys Asp Thr Lys Asp Ile Ser Ala Pro Lys Pro Gly Pro Leu Lys 
    530                 535                 540                 


Lys Ala Pro Ala Ala Lys Ala Gly Gly Pro Pro Lys Lys Gly Lys Pro 
545                 550                 555                 560 


Ala Ala Pro Gly Gly Ala Gly Asn Thr Gly Thr Lys Asn Lys Lys Gly 
                565                 570                 575     


Leu Glu Thr Lys Glu Ile Val Glu Pro Glu Leu Ser Ile Glu Val Cys 
            580                 585                 590         


Glu Glu Lys Ala Ser Ala Val Leu Pro Pro Thr Cys Ile Gln Leu Leu 
        595                 600                 605             


Asp Ser Ser Asn Trp Lys Glu Arg Leu Ala Cys Met Glu Glu Phe Gln 
    610                 615                 620                 


Lys Ala Val Glu Leu Met Asp Arg Thr Glu Met Pro Cys Gln Ala Leu 
625                 630                 635                 640 


Val Arg Met Leu Ala Lys Lys Pro Gly Trp Lys Glu Thr Asn Phe Gln 
                645                 650                 655     


Val Met Gln Met Lys Leu His Ile Val Ala Leu Ile Ala Gln Lys Gly 
            660                 665                 670         


Asn Phe Ser Lys Thr Ser Ala Gln Val Val Leu Asp Gly Leu Val Asp 
        675                 680                 685             


Lys Ile Gly Asp Val Lys Cys Gly Asn Asn Ala Lys Glu Ala Met Thr 
    690                 695                 700                 


Ala Ile Ala Glu Ala Cys Met Leu Pro Trp Thr Ala Glu Gln Val Val 
705                 710                 715                 720 


Ser Met Ala Phe Ser Gln Lys Asn Pro Lys Asn Gln Ser Glu Thr Leu 
                725                 730                 735     


Asn Trp Leu Ser Asn Ala Ile Lys Glu Phe Gly Phe Ser Gly Leu Asn 
            740                 745                 750         


Val Lys Ala Phe Ile Ser Asn Val Lys Thr Ala Leu Ala Ala Thr Asn 
        755                 760                 765             


Pro Ala Val Arg Thr Ala Ala Ile Thr Leu Leu Gly Val Met Tyr Leu 
    770                 775                 780                 


Tyr Val Gly Pro Ser Leu Arg Met Phe Phe Glu Asp Glu Lys Pro Ala 
785                 790                 795                 800 


Leu Leu Ser Gln Ile Asp Ala Glu Phe Glu Lys Met Gln Gly Gln Ser 
                805                 810                 815     


Pro Pro Ala Pro Thr Arg Gly Ile Ser Lys His Ser Thr Ser Gly Thr 
            820                 825                 830         


Asp Glu Gly Glu Asp Gly Asp Glu Pro Asp Asp Gly Ser Asn Asp Val 
        835                 840                 845             


Val Asp Leu Leu Pro Arg Thr Glu Ile Ser Asp Lys Ile Thr Ser Glu 
    850                 855                 860                 


Leu Val Ser Lys Ile Gly Asp Lys Asn Trp Lys Ile Arg Lys Glu Gly 
865                 870                 875                 880 


Leu Asp Glu Val Ala Gly Ile Ile Asn Asp Ala Lys Phe Ile Gln Pro 
                885                 890                 895     


Asn Ile Gly Glu Leu Pro Thr Ala Leu Lys Gly Arg Leu Asn Asp Ser 
            900                 905                 910         


Asn Lys Ile Leu Val Gln Gln Thr Leu Asn Ile Leu Gln Gln Leu Ala 
        915                 920                 925             


Val Ala Met Gly Pro Asn Ile Lys Gln His Val Lys Asn Leu Gly Ile 
    930                 935                 940                 


Pro Ile Ile Thr Val Leu Gly Asp Ser Lys Asn Asn Val Arg Ala Ala 
945                 950                 955                 960 


Ala Leu Ala Thr Val Asn Ala Trp Ala Glu Gln Thr Gly Met Lys Glu 
                965                 970                 975     


Trp Leu Glu Gly Glu Asp Leu Ser Glu Glu Leu Lys Lys Glu Asn Pro 
            980                 985                 990         


Phe Leu Arg Gln Glu Leu Leu Gly  Trp Leu Ala Glu Lys  Leu Pro Thr 
        995                 1000                 1005             


Leu Arg  Ser Thr Pro Thr Asp  Leu Ile Leu Cys Val  Pro His Leu 
    1010                 1015                 1020             


Tyr Ser  Cys Leu Glu Asp Arg  Asn Gly Asp Val Arg  Lys Lys Ala 
    1025                 1030                 1035             


Gln Asp  Ala Leu Pro Phe Phe  Met Met His Leu Gly  Tyr Glu Lys 
    1040                 1045                 1050             


Met Ala  Lys Ala Thr Gly Lys  Leu Lys Pro Thr Ser  Lys Asp Gln 
    1055                 1060                 1065             


Val Leu  Ala Met Leu Glu Lys  Ala Lys Val Asn Met  Pro Ala Lys 
    1070                 1075                 1080             


Pro Ala  Pro Pro Thr Lys Ala  Thr Ser Lys Pro Met  Gly Gly Ser 
    1085                 1090                 1095             


Ala Pro  Ala Lys Phe Gln Pro  Ala Ser Ala Pro Ala  Glu Asp Cys 
    1100                 1105                 1110             


Ile Ser  Ser Ser Thr Glu Pro  Lys Pro Asp Pro Lys  Lys Ala Lys 
    1115                 1120                 1125             


Ala Pro  Gly Leu Ser Ser Lys  Ala Lys Ser Ala Gln  Gly Lys Lys 
    1130                 1135                 1140             


Met Pro  Ser Lys Thr Ser Leu  Lys Glu Asp Glu Asp  Lys Ser Gly 
    1145                 1150                 1155             


Pro Ile  Phe Ile Val Val Pro  Asn Gly Lys Glu Gln  Arg Met Lys 
    1160                 1165                 1170             


Asp Glu  Lys Gly Leu Lys Val  Leu Lys Trp Asn Phe  Thr Thr Pro 
    1175                 1180                 1185             


Arg Asp  Glu Tyr Ile Glu Gln  Leu Lys Thr Gln Met  Ser Ser Cys 
    1190                 1195                 1200             


Val Ala  Lys Trp Leu Gln Asp  Glu Met Phe His Ser  Asp Phe Gln 
    1205                 1210                 1215             


His His  Asn Lys Ala Leu Ala  Val Met Val Asp His  Leu Glu Ser 
    1220                 1225                 1230             


Glu Lys  Glu Gly Val Ile Gly  Cys Leu Asp Leu Ile  Leu Lys Trp 
    1235                 1240                 1245             


Leu Thr  Leu Arg Phe Phe Asp  Thr Asn Thr Ser Val  Leu Met Lys 
    1250                 1255                 1260             


Ala Leu  Glu Tyr Leu Lys Leu  Leu Phe Thr Leu Leu  Ser Glu Glu 
    1265                 1270                 1275             


Glu Tyr  His Leu Thr Glu Asn  Glu Ala Ser Ser Phe  Ile Pro Tyr 
    1280                 1285                 1290             


Leu Val  Val Lys Val Gly Glu  Pro Lys Asp Val Ile  Arg Lys Asp 
    1295                 1300                 1305             


Val Arg  Ala Ile Leu Asn Arg  Met Cys Leu Val Tyr  Pro Ala Ser 
    1310                 1315                 1320             


Lys Met  Phe Pro Phe Ile Met  Glu Gly Thr Lys Ser  Lys Asn Ser 
    1325                 1330                 1335             


Lys Gln  Arg Ala Glu Cys Leu  Glu Glu Leu Gly Cys  Leu Val Glu 
    1340                 1345                 1350             


Ser Tyr  Gly Met Asn Val Cys  Gln Pro Thr Pro Gly  Lys Ala Leu 
    1355                 1360                 1365             


Lys Glu  Ile Ala Val His Ile  Gly Asp Arg Asp Asn  Ala Val Arg 
    1370                 1375                 1380             


Asn Ala  Ala Leu Asn Thr Ile  Val Thr Val Tyr Asn  Val His Gly 
    1385                 1390                 1395             


Asp Gln  Val Phe Lys Leu Ile  Gly Asn Leu Ser Glu  Lys Asp Met 
    1400                 1405                 1410             


Ser Met  Leu Glu Glu Arg Ile  Lys Arg Ser Ala Lys  Arg Pro Ser 
    1415                 1420                 1425             


Ala Ala  Pro Ile Lys Gln Val  Glu Glu Lys Pro Gln  Arg Ala Gln 
    1430                 1435                 1440             


Asn Ile  Ser Ser Asn Ala Asn  Met Leu Arg Lys Gly  Pro Ala Glu 
    1445                 1450                 1455             


Asp Met  Ser Ser Lys Leu Asn  Gln Ala Arg Ser Met  Ser Gly His 
    1460                 1465                 1470             


Pro Glu  Ala Ala Gln Met Val  Arg Arg Glu Phe Gln  Leu Asp Leu 
    1475                 1480                 1485             


Asp Glu  Ile Glu Asn Asp Asn  Gly Thr Val Arg Cys  Glu Met Pro 
    1490                 1495                 1500             


Glu Leu  Val Gln His Lys Leu  Asp Asp Ile Phe Glu  Pro Val Leu 
    1505                 1510                 1515             


Ile Pro  Glu Pro Lys Ile Arg  Ala Val Ser Pro His  Phe Asp Asp 
    1520                 1525                 1530             


Met His  Ser Asn Thr Ala Ser  Thr Ile Asn Phe Ile  Ile Ser Gln 
    1535                 1540                 1545             


Val Ala  Ser Gly Asp Ile Asn  Thr Ser Ile Gln Ala  Leu Thr Gln 
    1550                 1555                 1560             


Ile Asp  Glu Val Leu Arg Gln  Glu Asp Lys Ala Glu  Ala Met Ser 
    1565                 1570                 1575             


Gly His  Ile Asp Gln Phe Leu  Ile Ala Thr Phe Met  Gln Leu Arg 
    1580                 1585                 1590             


Leu Ile  Tyr Asn Thr His Met  Ala Asp Glu Lys Leu  Glu Lys Asp 
    1595                 1600                 1605             


Glu Ile  Ile Lys Leu Tyr Ser  Cys Ile Ile Gly Asn  Met Ile Ser 
    1610                 1615                 1620             


Leu Phe  Gln Ile Glu Ser Leu  Ala Arg Glu Ala Ser  Thr Gly Val 
    1625                 1630                 1635             


Leu Lys  Asp Leu Met His Gly  Leu Ile Thr Leu Met  Leu Asp Ser 
    1640                 1645                 1650             


Arg Ile  Glu Asp Leu Glu Glu  Gly Gln Gln Val Ile  Arg Ser Val 
    1655                 1660                 1665             


Asn Leu  Leu Val Val Lys Val  Leu Glu Lys Ser Asp  Gln Thr Asn 
    1670                 1675                 1680             


Ile Leu  Ser Ala Leu Leu Val  Leu Leu Gln Asp Ser  Leu Leu Ala 
    1685                 1690                 1695             


Thr Ala  Ser Ser Pro Lys Phe  Ser Glu Leu Val Met  Lys Cys Leu 
    1700                 1705                 1710             


Trp Arg  Met Val Arg Leu Leu  Pro Asp Thr Ile Asn  Ser Ile Asn 
    1715                 1720                 1725             


Leu Asp  Arg Ile Leu Leu Asp  Ile His Ile Phe Met  Lys Val Phe 
    1730                 1735                 1740             


Pro Lys  Glu Lys Leu Lys Gln  Cys Lys Ser Glu Phe  Pro Ile Arg 
    1745                 1750                 1755             


Thr Leu  Lys Thr Leu Leu His  Thr Leu Cys Lys Leu  Lys Gly Pro 
    1760                 1765                 1770             


Lys Ile  Leu Asp His Leu Thr  Met Ile Asp Asn Lys  Asn Glu Ser 
    1775                 1780                 1785             


Glu Leu  Glu Ala His Leu Cys  Arg Met Met Lys His  Ser Met Asp 
    1790                 1795                 1800             


Gln Thr  Gly Ser Lys Ser Asp  Lys Glu Thr Glu Lys  Gly Ala Ser 
    1805                 1810                 1815             


Arg Ile  Asp Glu Lys Ser Ser  Lys Ala Lys Val Asn  Asp Phe Leu 
    1820                 1825                 1830             


Ala Glu  Ile Phe Lys Lys Ile  Gly Ser Lys Glu Asn  Thr Lys Glu 
    1835                 1840                 1845             


Gly Leu  Ala Glu Leu Tyr Glu  Tyr Lys Lys Lys Tyr  Ser Asp Ala 
    1850                 1855                 1860             


Asp Ile  Glu Pro Phe Leu Lys  Asn Ser Ser Gln Phe  Phe Gln Ser 
    1865                 1870                 1875             


Tyr Val  Glu Arg Gly Leu Arg  Val Ile Glu Met Glu  Arg Glu Gly 
    1880                 1885                 1890             


Lys Gly  Arg Ile Ser Thr Ser  Thr Gly Ile Ser Pro  Gln Met Glu 
    1895                 1900                 1905             


Val Thr  Cys Val Pro Thr Pro  Thr Ser Thr Val Ser  Ser Ile Gly 
    1910                 1915                 1920             


Asn Thr  Asn Gly Glu Glu Val  Gly Pro Ser Val Tyr  Leu Glu Arg 
    1925                 1930                 1935             


Leu Lys  Ile Leu Arg Gln Arg  Cys Gly Leu Asp Asn  Thr Lys Gln 
    1940                 1945                 1950             


Asp Asp  Arg Pro Pro Leu Thr  Ser Leu Leu Ser Lys  Pro Ala Val 
    1955                 1960                 1965             


Pro Thr  Val Ala Ser Ser Thr  Asp Met Leu His Ser  Lys Leu Ser 
    1970                 1975                 1980             


Gln Leu  Arg Glu Ser Arg Glu  Gln His Gln His Ser  Asp Leu Asp 
    1985                 1990                 1995             


Ser Asn  Gln Thr His Ser Ser  Gly Thr Val Thr Ser  Ser Ser Ser 
    2000                 2005                 2010             


Thr Ala  Asn Ile Asp Asp Leu  Lys Lys Arg Leu Glu  Arg Ile Lys 
    2015                 2020                 2025             


Ser Ser  Arg Lys 
    2030         


<210>  2219
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKB__Homo_sapiens__NP_001814

<400>  2219

Met Pro Phe Ser Asn Ser His Asn Ala Leu Lys Leu Arg Phe Pro Ala 
1               5                   10                  15      


Glu Asp Glu Phe Pro Asp Leu Ser Ala His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Ser Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Tyr Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro 
            100                 105                 110         


Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu 
145                 150                 155                 160 


Ala Leu Ser Ser Leu Asp Gly Asp Leu Ala Gly Arg Tyr Tyr Ala Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly 
                245                 250                 255     


Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asp Tyr Glu Phe Met 
            260                 265                 270         


Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Asn Leu Gly Lys 
    290                 295                 300                 


His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu 
        355                 360                 365             


Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys 
    370                 375                 380     


<210>  2220
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKLF__Homo_sapiens__NP_001035228

<400>  2220

Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Ala Leu Thr Val Thr Ser 
            20                  25                  30          


Met Thr Phe Phe Ile Ile Ala Gln Ala Pro Glu Pro Tyr Ile Val Ile 
        35                  40                  45              


Thr Gly Phe Glu Val Thr Val Ile Leu Phe Phe Ile Leu Leu Tyr Val 
    50                  55                  60                  


Leu Arg Leu Asp Arg Leu Met Lys Trp Leu Phe Trp Pro Leu Leu Asp 
65                  70                  75                  80  


Ile Ile Asn Ser Leu Val Thr Thr Val Phe Met Leu Ile Val Ser Val 
                85                  90                  95      


Leu Ala Leu Ile Pro Glu Thr Thr Thr Leu Thr Val Gly Gly Gly Leu 
            100                 105                 110         


Phe 
    


<210>  2221
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKM__Homo_sapiens__NP_001815

<400>  2221

Met Pro Phe Gly Asn Thr His Asn Lys Phe Lys Leu Asn Tyr Lys Pro 
1               5                   10                  15      


Glu Glu Glu Tyr Pro Asp Leu Ser Lys His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Leu Glu Leu Tyr Lys Lys Leu Arg Asp Lys Glu Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Val Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Phe Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Glu Leu Phe Asp Pro Ile Ile Ser Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Thr Asp Lys His Lys Thr Asp Leu Asn His 
            100                 105                 110         


Glu Asn Leu Lys Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Lys Gly Tyr Thr Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Val Glu Lys Leu Ser Val Glu 
145                 150                 155                 160 


Ala Leu Asn Ser Leu Thr Gly Glu Phe Lys Gly Lys Tyr Tyr Pro Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Lys Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Ser 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Glu Lys Gly Gly Asn Met Lys Glu Val Phe Arg Arg Phe Cys Val Gly 
                245                 250                 255     


Leu Gln Lys Ile Glu Glu Ile Phe Lys Lys Ala Gly His Pro Phe Met 
            260                 265                 270         


Trp Asn Gln His Leu Gly Tyr Val Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Gly Gly Val His Val Lys Leu Ala His Leu Ser Lys 
    290                 295                 300                 


His Pro Lys Phe Glu Glu Ile Leu Thr Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Ser Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Ser Ser Glu Val Glu Gln Val Gln Leu 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Met Val Glu Met Glu Lys Lys Leu Glu 
        355                 360                 365             


Lys Gly Gln Ser Ile Asp Asp Met Ile Pro Ala Gln Lys 
    370                 375                 380     


<210>  2222
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKMT1A__Homo_sapiens__XP_005254555

<400>  2222

Met Pro Val Lys Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu 
1               5                   10                  15      


Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val 
            20                  25                  30          


Val Asp Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr 
        35                  40                  45              


Arg Leu Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp 
    50                  55                  60                  


His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly 
65                  70                  75                  80  


Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu 
                85                  90                  95      


Lys Ser Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile 
            100                 105                 110         


Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys 
        115                 120                 125             


Arg Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu 
    130                 135                 140                 


Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn 
145                 150                 155                 160 


Leu Gly Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu 
                165                 170                 175     


Ser Lys Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln 
            180                 185                 190         


Lys Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe 
        195                 200                 205             


Asp Ile Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val 
    210                 215                 220                 


Gln Leu Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg 
225                 230                 235                 240 


Leu Glu Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr 
                245                 250                 255     


Lys His 
        


<210>  2223
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKMT1B__Homo_sapiens__XP_011519498

<400>  2223

Met Ala Gly Pro Phe Ser Arg Leu Leu Ser Ala Arg Pro Gly Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Ala Gly Ala Gly Ser Leu Ala Ala Gly Phe Leu Leu 
            20                  25                  30          


Arg Pro Glu Pro Val Arg Ala Ala Ser Glu Arg Arg Arg Leu Tyr Pro 
        35                  40                  45              


Pro Ser Gln Thr Trp Pro Thr Gly Gln Leu Pro Gly Asn Cys Thr Arg 
    50                  55                  60                  


Ser Arg Arg Leu Cys Pro Pro Ser Met Val Thr Gly Tyr Pro Leu Pro 
65                  70                  75                  80  


Ser Ala Glu Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met Ala Ser 
                85                  90                  95      


His Leu Thr Pro Ala Val Tyr Ala Arg Leu Cys Asp Lys Thr Thr Pro 
            100                 105                 110         


Thr Gly Trp Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp Asn Pro 
        115                 120                 125             


Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp Glu Glu 
    130                 135                 140                 


Thr Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Gln Glu Arg 
145                 150                 155                 160 


His Asn Gly Tyr Asp Pro Arg Thr Met Lys His Thr Thr Asp Leu Asp 
                165                 170                 175     


Ala Ser Lys Ile Arg Ser Gly Tyr Phe Asp Glu Arg Tyr Val Leu Ser 
            180                 185                 190         


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu Pro Pro 
        195                 200                 205             


Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Arg Val Val Val Asp 
    210                 215                 220                 


Ala Leu Ser Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr Arg Leu 
225                 230                 235                 240 


Ser Glu Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
                245                 250                 255     


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Ala Ala Gly Met Ala 
            260                 265                 270         


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asn Glu Lys Ser 
        275                 280                 285             


Phe Leu Ile Trp Val Asn Glu Glu Asp His Thr Arg Val Ile Ser Met 
    290                 295                 300                 


Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys Arg Gly 
305                 310                 315                 320 


Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu Phe Met 
                325                 330                 335     


Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
            340                 345                 350         


Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Leu Leu Ser Lys 
        355                 360                 365             


Asp Ser Arg Phe Pro Lys Ile Leu Glu Asn Leu Arg Leu Gln Lys Arg 
    370                 375                 380                 


Gly Thr Gly Gly Val Asp Thr Ala Ala Thr Gly Gly Val Phe Asp Ile 
385                 390                 395                 400 


Ser Asn Leu Asp Arg Leu Gly Lys Ser Glu Val Glu Leu Val Gln Leu 
                405                 410                 415     


Val Ile Asp Gly Val Asn Tyr Leu Ile Asp Cys Glu Arg Arg Leu Glu 
            420                 425                 430         


Arg Gly Gln Asp Ile Arg Ile Pro Thr Pro Val Ile His Thr Lys His 
        435                 440                 445             


<210>  2224
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKMT2__Homo_sapiens__NP_001093206

<400>  2224

Met Ala Ser Ile Phe Ser Lys Leu Leu Thr Gly Arg Asn Ala Ser Leu 
1               5                   10                  15      


Leu Phe Ala Thr Met Gly Thr Ser Val Leu Thr Thr Gly Tyr Leu Leu 
            20                  25                  30          


Asn Arg Gln Lys Val Cys Ala Glu Val Arg Glu Gln Pro Arg Leu Phe 
        35                  40                  45              


Pro Pro Ser Ala Asp Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met 
    50                  55                  60                  


Ala Glu Cys Leu Thr Pro Ala Ile Tyr Ala Lys Leu Arg Asn Lys Val 
65                  70                  75                  80  


Thr Pro Asn Gly Tyr Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp 
                85                  90                  95      


Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp 
            100                 105                 110         


Glu Glu Ser Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Lys 
        115                 120                 125             


Leu Arg His Asn Gly Tyr Asp Pro Arg Val Met Lys His Thr Thr Asp 
    130                 135                 140                 


Leu Asp Ala Ser Lys Ile Thr Gln Gly Gln Phe Asp Glu His Tyr Val 
145                 150                 155                 160 


Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu 
                165                 170                 175     


Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Asn Val Ala 
            180                 185                 190         


Ile Thr Ala Leu Glu Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr 
        195                 200                 205             


Lys Leu Ser Glu Met Thr Glu Gln Asp Gln Gln Arg Leu Ile Asp Asp 
    210                 215                 220                 


His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Cys Ala Gly 
225                 230                 235                 240 


Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Tyr Asp 
                245                 250                 255     


Lys Thr Phe Leu Ile Trp Ile Asn Glu Glu Asp His Thr Arg Val Ile 
            260                 265                 270         


Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys 
        275                 280                 285             


Arg Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu 
    290                 295                 300                 


Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn 
305                 310                 315                 320 


Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Arg Ile Pro Lys Leu 
                325                 330                 335     


Ser Lys Asp Pro Arg Phe Ser Lys Ile Leu Glu Asn Leu Arg Leu Gln 
            340                 345                 350         


Lys Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Val Ala Asp Val Tyr 
        355                 360                 365             


Asp Ile Ser Asn Ile Asp Arg Ile Gly Arg Ser Glu Val Glu Leu Val 
    370                 375                 380                 


Gln Ile Val Ile Asp Gly Val Asn Tyr Leu Val Asp Cys Glu Lys Lys 
385                 390                 395                 400 


Leu Glu Arg Gly Gln Asp Ile Lys Val Pro Pro Pro Leu Pro Gln Phe 
                405                 410                 415     


Gly Lys Lys 
            


<210>  2225
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKS1B__Homo_sapiens__NP_001817

<400>  2225

Met Ser His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Asp Asp Glu Glu 
1               5                   10                  15      


Phe Glu Tyr Arg His Val Met Leu Pro Lys Asp Ile Ala Lys Leu Val 
            20                  25                  30          


Pro Lys Thr His Leu Met Ser Glu Ser Glu Trp Arg Asn Leu Gly Val 
        35                  40                  45              


Gln Gln Ser Gln Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro 
    50                  55                  60                  


His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Lys Pro Lys Lys 
65                  70                  75                  


<210>  2226
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CKS2__Homo_sapiens__NP_001818

<400>  2226

Met Ala His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Phe Asp Glu His 
1               5                   10                  15      


Tyr Glu Tyr Arg His Val Met Leu Pro Arg Glu Leu Ser Lys Gln Val 
            20                  25                  30          


Pro Lys Thr His Leu Met Ser Glu Glu Glu Trp Arg Arg Leu Gly Val 
        35                  40                  45              


Gln Gln Ser Leu Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro 
    50                  55                  60                  


His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Asp Gln Gln Lys 
65                  70                  75                  


<210>  2227
<211>  1479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLASP1__Homo_sapiens__NP_001135745

<400>  2227

Met Glu Pro Arg Met Glu Ser Cys Leu Ala Gln Val Leu Gln Lys Asp 
1               5                   10                  15      


Val Gly Lys Arg Leu Gln Val Gly Gln Glu Leu Ile Asp Tyr Phe Ser 
            20                  25                  30          


Asp Lys Gln Lys Ser Ala Asp Leu Glu His Asp Gln Thr Met Leu Asp 
        35                  40                  45              


Lys Leu Val Asp Gly Leu Ala Thr Ser Trp Val Asn Ser Ser Asn Tyr 
    50                  55                  60                  


Lys Val Val Leu Leu Gly Met Asp Ile Leu Ser Ala Leu Val Thr Arg 
65                  70                  75                  80  


Leu Gln Asp Arg Phe Lys Ala Gln Ile Gly Thr Val Leu Pro Ser Leu 
                85                  90                  95      


Ile Asp Arg Leu Gly Asp Ala Lys Asp Ser Val Arg Glu Gln Asp Gln 
            100                 105                 110         


Thr Leu Leu Leu Lys Ile Met Asp Gln Ala Ala Asn Pro Gln Tyr Val 
        115                 120                 125             


Trp Asp Arg Met Leu Gly Gly Phe Lys His Lys Asn Phe Arg Thr Arg 
    130                 135                 140                 


Glu Gly Ile Cys Leu Cys Leu Ile Ala Thr Leu Asn Ala Ser Gly Ala 
145                 150                 155                 160 


Gln Thr Leu Thr Leu Ser Lys Ile Val Pro His Ile Cys Asn Leu Leu 
                165                 170                 175     


Gly Asp Pro Asn Ser Gln Val Arg Asp Ala Ala Ile Asn Ser Leu Val 
            180                 185                 190         


Glu Ile Tyr Arg His Val Gly Glu Arg Val Arg Ala Asp Leu Ser Lys 
        195                 200                 205             


Lys Gly Leu Pro Gln Ser Arg Leu Asn Val Ile Phe Thr Lys Phe Asp 
    210                 215                 220                 


Glu Val Gln Lys Ser Gly Asn Met Ile Gln Ser Ala Asn Asp Lys Asn 
225                 230                 235                 240 


Phe Asp Asp Glu Asp Ser Val Asp Gly Asn Arg Pro Ser Ser Ala Ser 
                245                 250                 255     


Ser Thr Ser Ser Lys Ala Pro Pro Ser Ser Arg Arg Asn Val Gly Met 
            260                 265                 270         


Gly Thr Thr Arg Arg Leu Gly Ser Ser Thr Leu Gly Ser Lys Ser Ser 
        275                 280                 285             


Ala Ala Lys Glu Gly Ala Gly Ala Val Asp Glu Glu Asp Phe Ile Lys 
    290                 295                 300                 


Ala Phe Asp Asp Val Pro Val Val Gln Ile Tyr Ser Ser Arg Asp Leu 
305                 310                 315                 320 


Glu Glu Ser Ile Asn Lys Ile Arg Glu Ile Leu Ser Asp Asp Lys His 
                325                 330                 335     


Asp Trp Glu Gln Arg Val Asn Ala Leu Lys Lys Ile Arg Ser Leu Leu 
            340                 345                 350         


Leu Ala Gly Ala Ala Glu Tyr Asp Asn Phe Phe Gln His Leu Arg Leu 
        355                 360                 365             


Leu Asp Gly Ala Phe Lys Leu Ser Ala Lys Asp Leu Arg Ser Gln Val 
    370                 375                 380                 


Val Arg Glu Ala Cys Ile Thr Leu Gly His Leu Ser Ser Val Leu Gly 
385                 390                 395                 400 


Asn Lys Phe Asp His Gly Ala Glu Ala Ile Met Pro Thr Ile Phe Asn 
                405                 410                 415     


Leu Ile Pro Asn Ser Ala Lys Ile Met Ala Thr Ser Gly Val Val Ala 
            420                 425                 430         


Val Arg Leu Ile Ile Arg His Thr His Ile Pro Arg Leu Ile Pro Val 
        435                 440                 445             


Ile Thr Ser Asn Cys Thr Ser Lys Ser Val Ala Val Arg Arg Arg Cys 
    450                 455                 460                 


Phe Glu Phe Leu Asp Leu Leu Leu Gln Glu Trp Gln Thr His Ser Leu 
465                 470                 475                 480 


Glu Arg His Ile Ser Val Leu Ala Glu Thr Ile Lys Lys Gly Ile His 
                485                 490                 495     


Asp Ala Asp Ser Glu Ala Arg Ile Glu Ala Arg Lys Cys Tyr Trp Gly 
            500                 505                 510         


Phe His Ser His Phe Ser Arg Glu Ala Glu His Leu Tyr His Thr Leu 
        515                 520                 525             


Glu Ser Ser Tyr Gln Lys Ala Leu Gln Ser His Leu Lys Asn Ser Asp 
    530                 535                 540                 


Ser Ile Val Ser Leu Pro Gln Ser Asp Arg Ser Ser Ser Ser Ser Gln 
545                 550                 555                 560 


Glu Ser Leu Asn Arg Pro Leu Ser Ala Lys Arg Ser Pro Thr Gly Ser 
                565                 570                 575     


Thr Thr Ser Arg Ala Ser Thr Val Ser Thr Lys Ser Val Ser Thr Thr 
            580                 585                 590         


Gly Ser Leu Gln Arg Ser Arg Ser Asp Ile Asp Val Asn Ala Ala Ala 
        595                 600                 605             


Ser Ala Lys Ser Lys Val Ser Ser Ser Ser Gly Thr Thr Pro Phe Ser 
    610                 615                 620                 


Ser Ala Ala Ala Leu Pro Pro Gly Ser Tyr Ala Ser Leu Asp Gly Thr 
625                 630                 635                 640 


Thr Thr Lys Ala Glu Gly Arg Ile Arg Thr Arg Arg Gln Ser Ser Gly 
                645                 650                 655     


Ser Ala Thr Asn Val Ala Ser Thr Pro Asp Asn Arg Gly Arg Ser Arg 
            660                 665                 670         


Ala Lys Val Val Ser Gln Ser Gln Arg Ser Arg Ser Ala Asn Pro Ala 
        675                 680                 685             


Gly Ala Gly Ser Arg Ser Ser Ser Pro Gly Lys Leu Leu Gly Ser Gly 
    690                 695                 700                 


Tyr Gly Gly Leu Thr Gly Gly Ser Ser Arg Gly Pro Pro Val Thr Pro 
705                 710                 715                 720 


Ser Ser Glu Lys Arg Ser Lys Ile Pro Arg Ser Gln Gly Cys Ser Arg 
                725                 730                 735     


Glu Thr Ser Pro Asn Arg Ile Gly Leu Asp Arg Phe Gly Leu Gly Gln 
            740                 745                 750         


Pro Gly Arg Ile Pro Gly Ser Val Asn Ala Met Arg Val Leu Ser Thr 
        755                 760                 765             


Ser Thr Asp Leu Glu Ala Ala Val Ala Asp Ala Leu Leu Leu Gly Asp 
    770                 775                 780                 


Ser Arg Ser Lys Lys Lys Pro Val Arg Arg Arg Tyr Glu Pro Tyr Gly 
785                 790                 795                 800 


Met Tyr Ser Asp Asp Asp Ala Asn Ser Asp Ala Ser Ser Val Cys Ser 
                805                 810                 815     


Glu Arg Ser Tyr Gly Ser Arg Asn Gly Gly Ile Pro His Tyr Leu Arg 
            820                 825                 830         


Gln Thr Glu Asp Val Ala Glu Val Leu Asn His Cys Ala Ser Ser Asn 
        835                 840                 845             


Trp Ser Glu Arg Lys Glu Gly Leu Leu Gly Leu Gln Asn Leu Leu Lys 
    850                 855                 860                 


Ser Gln Arg Thr Leu Ser Arg Val Glu Leu Lys Arg Leu Cys Glu Ile 
865                 870                 875                 880 


Phe Thr Arg Met Phe Ala Asp Pro His Ser Lys Arg Val Phe Ser Met 
                885                 890                 895     


Phe Leu Glu Thr Leu Val Asp Phe Ile Ile Ile His Lys Asp Asp Leu 
            900                 905                 910         


Gln Asp Trp Leu Phe Val Leu Leu Thr Gln Leu Leu Lys Lys Met Gly 
        915                 920                 925             


Ala Asp Leu Leu Gly Ser Val Gln Ala Lys Val Gln Lys Ala Leu Asp 
    930                 935                 940                 


Val Thr Arg Asp Ser Phe Pro Phe Asp Gln Gln Phe Asn Ile Leu Met 
945                 950                 955                 960 


Arg Phe Ile Val Asp Gln Thr Gln Thr Pro Asn Leu Lys Val Lys Val 
                965                 970                 975     


Ala Ile Leu Lys Tyr Ile Glu Ser Leu Ala Arg Gln Met Asp Pro Thr 
            980                 985                 990         


Asp Phe Val Asn Ser Ser Glu Thr  Arg Leu Ala Val Ser  Arg Ile Ile 
        995                 1000                 1005             


Thr Trp  Thr Thr Glu Pro Lys  Ser Ser Asp Val Arg  Lys Ala Ala 
    1010                 1015                 1020             


Gln Ile  Val Leu Ile Ser Leu  Phe Glu Leu Asn Thr  Pro Glu Phe 
    1025                 1030                 1035             


Thr Met  Leu Leu Gly Ala Leu  Pro Lys Thr Phe Gln  Asp Gly Ala 
    1040                 1045                 1050             


Thr Lys  Leu Leu His Asn His  Leu Lys Asn Ser Ser  Asn Thr Ser 
    1055                 1060                 1065             


Val Gly  Ser Pro Ser Asn Thr  Ile Gly Arg Thr Pro  Ser Arg His 
    1070                 1075                 1080             


Thr Ser  Ser Arg Thr Ser Pro  Leu Thr Ser Pro Thr  Asn Cys Ser 
    1085                 1090                 1095             


His Gly  Gly Leu Ser Pro Ser  Met Leu Asp Tyr Asp  Thr Glu Asn 
    1100                 1105                 1110             


Leu Asn  Ser Glu Glu Ile Tyr  Ser Ser Leu Arg Gly  Val Thr Glu 
    1115                 1120                 1125             


Ala Ile  Glu Lys Phe Ser Phe  Arg Ser Gln Glu Asp  Leu Asn Glu 
    1130                 1135                 1140             


Pro Ile  Lys Arg Asp Gly Lys  Lys Glu Cys Asp Ile  Val Ser Arg 
    1145                 1150                 1155             


Asp Gly  Gly Ala Ala Ser Pro  Ala Thr Glu Gly Arg  Gly Gly Ser 
    1160                 1165                 1170             


Glu Val  Glu Gly Gly Arg Thr  Ala Leu Asp Asn Lys  Thr Ser Leu 
    1175                 1180                 1185             


Leu Asn  Thr Gln Pro Pro Arg  Ala Phe Pro Gly Pro  Arg Ala Arg 
    1190                 1195                 1200             


Asp Tyr  Asn Pro Tyr Pro Tyr  Ser Asp Ala Ile Asn  Thr Tyr Asp 
    1205                 1210                 1215             


Lys Thr  Ala Leu Lys Glu Ala  Val Phe Asp Asp Asp  Met Glu Gln 
    1220                 1225                 1230             


Leu Arg  Asp Val Pro Ile Asp  His Ser Asp Leu Val  Ala Asp Leu 
    1235                 1240                 1245             


Leu Lys  Glu Leu Ser Asn His  Asn Glu Arg Val Glu  Glu Arg Lys 
    1250                 1255                 1260             


Gly Ala  Leu Leu Glu Leu Leu  Lys Ile Thr Arg Glu  Asp Ser Leu 
    1265                 1270                 1275             


Gly Val  Trp Glu Glu His Phe  Lys Thr Ile Leu Leu  Leu Leu Leu 
    1280                 1285                 1290             


Glu Thr  Leu Gly Asp Lys Asp  His Ser Ile Arg Ala  Leu Ala Leu 
    1295                 1300                 1305             


Arg Val  Leu Arg Glu Ile Leu  Arg Asn Gln Pro Ala  Arg Phe Lys 
    1310                 1315                 1320             


Asn Tyr  Ala Glu Leu Thr Ile  Met Lys Thr Leu Glu  Ala His Lys 
    1325                 1330                 1335             


Asp Ser  His Lys Glu Val Val  Arg Ala Ala Glu Glu  Ala Ala Ser 
    1340                 1345                 1350             


Thr Leu  Ala Ser Ser Ile His  Pro Glu Gln Cys Ile  Lys Val Leu 
    1355                 1360                 1365             


Cys Pro  Ile Ile Gln Thr Ala  Asp Tyr Pro Ile Asn  Leu Ala Ala 
    1370                 1375                 1380             


Ile Lys  Met Gln Thr Lys Val  Val Glu Arg Ile Ala  Lys Glu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Leu Leu Val Asp  Ile Ile Pro Gly Leu  Leu Gln Gly 
    1400                 1405                 1410             


Tyr Asp  Asn Thr Glu Ser Ser  Val Arg Lys Ala Ser  Val Phe Cys 
    1415                 1420                 1425             


Leu Val  Ala Ile Tyr Ser Val  Ile Gly Glu Asp Leu  Lys Pro His 
    1430                 1435                 1440             


Leu Ala  Gln Leu Thr Gly Ser  Lys Met Lys Leu Leu  Asn Leu Tyr 
    1445                 1450                 1455             


Ile Lys  Arg Ala Gln Thr Thr  Asn Ser Asn Ser Ser  Ser Ser Ser 
    1460                 1465                 1470             


Asp Val  Ser Thr His Ser 
    1475                 


<210>  2228
<211>  1294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLASP2__Homo_sapiens__NP_001193973

<400>  2228

Met Ala Met Gly Asp Asp Lys Ser Phe Asp Asp Glu Glu Ser Val Asp 
1               5                   10                  15      


Gly Asn Arg Pro Ser Ser Ala Ala Ser Ala Phe Lys Val Pro Ala Pro 
            20                  25                  30          


Lys Thr Ser Gly Asn Pro Ala Asn Ser Ala Arg Lys Pro Gly Ser Ala 
        35                  40                  45              


Gly Gly Pro Lys Val Gly Gly Ala Ser Lys Glu Gly Gly Ala Gly Ala 
    50                  55                  60                  


Val Asp Glu Asp Asp Phe Ile Lys Ala Phe Thr Asp Val Pro Ser Ile 
65                  70                  75                  80  


Gln Ile Tyr Ser Ser Arg Glu Leu Glu Glu Thr Leu Asn Lys Ile Arg 
                85                  90                  95      


Glu Ile Leu Ser Asp Asp Lys His Asp Trp Asp Gln Arg Ala Asn Ala 
            100                 105                 110         


Leu Lys Lys Ile Arg Ser Leu Leu Val Ala Gly Ala Ala Gln Tyr Asp 
        115                 120                 125             


Cys Phe Phe Gln His Leu Arg Leu Leu Asp Gly Ala Leu Lys Leu Ser 
    130                 135                 140                 


Ala Lys Asp Leu Arg Ser Gln Val Val Arg Glu Ala Cys Ile Thr Val 
145                 150                 155                 160 


Ala His Leu Ser Thr Val Leu Gly Asn Lys Phe Asp His Gly Ala Glu 
                165                 170                 175     


Ala Ile Val Pro Thr Leu Phe Asn Leu Val Pro Asn Ser Ala Lys Val 
            180                 185                 190         


Met Ala Thr Ser Gly Cys Ala Ala Ile Arg Phe Ile Ile Arg His Thr 
        195                 200                 205             


His Val Pro Arg Leu Ile Pro Leu Ile Thr Ser Asn Cys Thr Ser Lys 
    210                 215                 220                 


Ser Val Pro Val Arg Arg Arg Ser Phe Glu Phe Leu Asp Leu Leu Leu 
225                 230                 235                 240 


Gln Glu Trp Gln Thr His Ser Leu Glu Arg His Ala Ala Val Leu Val 
                245                 250                 255     


Glu Thr Ile Lys Lys Gly Ile His Asp Ala Asp Ala Glu Ala Arg Val 
            260                 265                 270         


Glu Ala Arg Lys Thr Tyr Met Gly Leu Arg Asn His Phe Pro Gly Glu 
        275                 280                 285             


Ala Glu Thr Leu Tyr Asn Ser Leu Glu Pro Ser Tyr Gln Lys Ser Leu 
    290                 295                 300                 


Gln Thr Tyr Leu Lys Ser Ser Gly Ser Val Ala Ser Leu Pro Gln Ser 
305                 310                 315                 320 


Asp Arg Ser Ser Ser Ser Ser Gln Glu Ser Leu Asn Arg Pro Phe Ser 
                325                 330                 335     


Ser Lys Trp Ser Thr Ala Asn Pro Ser Thr Val Ala Gly Arg Val Ser 
            340                 345                 350         


Ala Gly Ser Ser Lys Ala Ser Ser Leu Pro Gly Ser Leu Gln Arg Ser 
        355                 360                 365             


Arg Ser Asp Ile Asp Val Asn Ala Ala Ala Gly Ala Lys Ala His His 
    370                 375                 380                 


Ala Ala Gly Gln Ser Val Arg Ser Gly Arg Leu Gly Ala Gly Ala Leu 
385                 390                 395                 400 


Asn Ala Gly Ser Tyr Ala Ser Leu Glu Asp Thr Ser Asp Lys Leu Asp 
                405                 410                 415     


Gly Thr Ala Ser Glu Asp Gly Arg Val Arg Ala Lys Leu Ser Ala Pro 
            420                 425                 430         


Leu Ala Gly Met Gly Asn Ala Lys Ala Asp Ser Arg Gly Arg Ser Arg 
        435                 440                 445             


Thr Lys Met Val Ser Gln Ser Gln Pro Gly Ser Arg Ser Gly Ser Pro 
    450                 455                 460                 


Gly Arg Val Leu Thr Thr Thr Ala Leu Ser Thr Val Ser Ser Gly Val 
465                 470                 475                 480 


Gln Arg Val Leu Val Asn Ser Ala Ser Ala Gln Lys Arg Ser Lys Ile 
                485                 490                 495     


Pro Arg Ser Gln Gly Cys Ser Arg Glu Ala Ser Pro Ser Arg Leu Ser 
            500                 505                 510         


Val Ala Arg Ser Ser Arg Ile Pro Arg Pro Ser Val Ser Gln Gly Cys 
        515                 520                 525             


Ser Arg Glu Ala Ser Arg Glu Ser Ser Arg Asp Thr Ser Pro Val Arg 
    530                 535                 540                 


Ser Phe Gln Pro Leu Ala Ser Arg His His Ser Arg Ser Thr Gly Ala 
545                 550                 555                 560 


Leu Tyr Ala Pro Glu Val Tyr Gly Ala Ser Gly Pro Gly Tyr Gly Ile 
                565                 570                 575     


Ser Gln Ser Ser Arg Leu Ser Ser Ser Val Ser Ala Met Arg Val Leu 
            580                 585                 590         


Asn Thr Gly Ser Asp Val Glu Glu Ala Val Ala Asp Ala Leu Lys Lys 
        595                 600                 605             


Pro Ala Arg Arg Arg Tyr Glu Ser Tyr Gly Met His Ser Asp Asp Asp 
    610                 615                 620                 


Ala Asn Ser Asp Ala Ser Ser Ala Cys Ser Glu Arg Ser Tyr Ser Ser 
625                 630                 635                 640 


Arg Asn Gly Ser Ile Pro Thr Tyr Met Arg Gln Thr Glu Asp Val Ala 
                645                 650                 655     


Glu Val Leu Asn Arg Cys Ala Ser Ser Asn Trp Ser Glu Arg Lys Glu 
            660                 665                 670         


Gly Leu Leu Gly Leu Gln Asn Leu Leu Lys Asn Gln Arg Thr Leu Ser 
        675                 680                 685             


Arg Val Glu Leu Lys Arg Leu Cys Glu Ile Phe Thr Arg Met Phe Ala 
    690                 695                 700                 


Asp Pro His Gly Lys Arg Val Phe Ser Met Phe Leu Glu Thr Leu Val 
705                 710                 715                 720 


Asp Phe Ile Gln Val His Lys Asp Asp Leu Gln Asp Trp Leu Phe Val 
                725                 730                 735     


Leu Leu Thr Gln Leu Leu Lys Lys Met Gly Ala Asp Leu Leu Gly Ser 
            740                 745                 750         


Val Gln Ala Lys Val Gln Lys Ala Leu Asp Val Thr Arg Glu Ser Phe 
        755                 760                 765             


Pro Asn Asp Leu Gln Phe Asn Ile Leu Met Arg Phe Thr Val Asp Gln 
    770                 775                 780                 


Thr Gln Thr Pro Ser Leu Lys Val Lys Val Ala Ile Leu Lys Tyr Ile 
785                 790                 795                 800 


Glu Thr Leu Ala Lys Gln Met Asp Pro Gly Asp Phe Ile Asn Ser Ser 
                805                 810                 815     


Glu Thr Arg Leu Ala Val Ser Arg Val Ile Thr Trp Thr Thr Glu Pro 
            820                 825                 830         


Lys Ser Ser Asp Val Arg Lys Ala Ala Gln Ser Val Leu Ile Ser Leu 
        835                 840                 845             


Phe Glu Leu Asn Thr Pro Glu Phe Thr Met Leu Leu Gly Ala Leu Pro 
    850                 855                 860                 


Lys Thr Phe Gln Asp Gly Ala Thr Lys Leu Leu His Asn His Leu Arg 
865                 870                 875                 880 


Asn Thr Gly Asn Gly Thr Gln Ser Ser Met Gly Ser Pro Leu Thr Arg 
                885                 890                 895     


Pro Thr Pro Arg Ser Pro Ala Asn Trp Ser Ser Pro Leu Thr Ser Pro 
            900                 905                 910         


Thr Asn Thr Ser Gln Asn Thr Leu Ser Pro Ser Ala Phe Asp Tyr Asp 
        915                 920                 925             


Thr Glu Asn Met Asn Ser Glu Asp Ile Tyr Ser Ser Leu Arg Gly Val 
    930                 935                 940                 


Thr Glu Ala Ile Gln Asn Phe Ser Phe Arg Ser Gln Glu Asp Met Asn 
945                 950                 955                 960 


Glu Pro Leu Lys Arg Asp Ser Lys Lys Asp Asp Gly Asp Ser Met Cys 
                965                 970                 975     


Gly Gly Pro Gly Met Ser Asp Pro Arg Ala Gly Gly Asp Ala Thr Asp 
            980                 985                 990         


Ser Ser Gln Thr Ala Leu Asp Asn  Lys Ala Ser Leu Leu  His Ser Met 
        995                 1000                 1005             


Pro Thr  His Ser Ser Pro Arg  Ser Arg Asp Tyr Asn  Pro Tyr Asn 
    1010                 1015                 1020             


Tyr Ser  Asp Ser Ile Ser Pro  Phe Asn Lys Ser Ala  Leu Lys Glu 
    1025                 1030                 1035             


Ala Met  Phe Asp Asp Asp Ala  Asp Gln Phe Pro Asp  Asp Leu Ser 
    1040                 1045                 1050             


Leu Asp  His Ser Asp Leu Val  Ala Glu Leu Leu Lys  Glu Leu Ser 
    1055                 1060                 1065             


Asn His  Asn Glu Arg Val Glu  Glu Arg Lys Ile Ala  Leu Tyr Glu 
    1070                 1075                 1080             


Leu Met  Lys Leu Thr Gln Glu  Glu Ser Phe Ser Val  Trp Asp Glu 
    1085                 1090                 1095             


His Phe  Lys Thr Ile Leu Leu  Leu Leu Leu Glu Thr  Leu Gly Asp 
    1100                 1105                 1110             


Lys Glu  Pro Thr Ile Arg Ala  Leu Ala Leu Lys Val  Leu Arg Glu 
    1115                 1120                 1125             


Ile Leu  Arg His Gln Pro Ala  Arg Phe Lys Asn Tyr  Ala Glu Leu 
    1130                 1135                 1140             


Thr Val  Met Lys Thr Leu Glu  Ala His Lys Asp Pro  His Lys Glu 
    1145                 1150                 1155             


Val Val  Arg Ser Ala Glu Glu  Ala Ala Ser Val Leu  Ala Thr Ser 
    1160                 1165                 1170             


Ile Ser  Pro Glu Gln Cys Ile  Lys Val Leu Cys Pro  Ile Ile Gln 
    1175                 1180                 1185             


Thr Ala  Asp Tyr Pro Ile Asn  Leu Ala Ala Ile Lys  Met Gln Thr 
    1190                 1195                 1200             


Lys Val  Ile Glu Arg Val Ser  Lys Glu Thr Leu Asn  Leu Leu Leu 
    1205                 1210                 1215             


Pro Glu  Ile Met Pro Gly Leu  Ile Gln Gly Tyr Asp  Asn Ser Glu 
    1220                 1225                 1230             


Ser Ser  Val Arg Lys Ala Cys  Val Phe Cys Leu Val  Ala Val His 
    1235                 1240                 1245             


Ala Val  Ile Gly Asp Glu Leu  Lys Pro His Leu Ser  Gln Leu Thr 
    1250                 1255                 1260             


Gly Ser  Lys Met Lys Leu Leu  Asn Leu Tyr Ile Lys  Arg Ala Gln 
    1265                 1270                 1275             


Thr Gly  Ser Gly Gly Ala Asp  Pro Thr Thr Asp Val  Ser Gly Gln 
    1280                 1285                 1290             


Ser 
    


<210>  2229
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCA2__Homo_sapiens__XP_011540750

<400>  2229

Met Thr Gln Arg Ser Ile Ala Gly Pro Ile Cys Asn Leu Lys Phe Val 
1               5                   10                  15      


Thr Leu Leu Val Ala Leu Ser Ser Glu Leu Pro Phe Leu Gly Ala Gly 
            20                  25                  30          


Val Gln Leu Gln Asp Asn Gly Tyr Asn Gly Leu Leu Ile Ala Ile Asn 
        35                  40                  45              


Pro Gln Val Pro Glu Asn Gln Asn Leu Ile Ser Asn Ile Lys Glu Met 
    50                  55                  60                  


Ile Thr Glu Ala Ser Phe Tyr Leu Phe Asn Ala Thr Lys Arg Arg Val 
65                  70                  75                  80  


Phe Phe Arg Asn Ile Lys Ile Leu Ile Pro Ala Thr Trp Lys Ala Asn 
                85                  90                  95      


Asn Asn Ser Lys Ile Lys Gln Glu Ser Tyr Glu Lys Ala Asn Val Ile 
            100                 105                 110         


Val Thr Asp Trp Tyr Gly Ala His Gly Asp Asp Pro Tyr Thr Leu Gln 
        115                 120                 125             


Tyr Arg Gly Cys Gly Lys Glu Gly Lys Tyr Ile His Phe Thr Pro Asn 
    130                 135                 140                 


Phe Leu Leu Asn Asp Asn Leu Thr Ala Gly Tyr Gly Ser Arg Gly Arg 
145                 150                 155                 160 


Val Phe Val His Glu Trp Ala His Leu Arg Trp Gly Val Phe Asp Glu 
                165                 170                 175     


Tyr Asn Asn Asp Lys Pro Phe Tyr Ile Asn Gly Gln Asn Gln Ile Lys 
            180                 185                 190         


Val Thr Arg Cys Ser Ser Asp Ile Thr Gly Ile Phe Val Cys Glu Lys 
        195                 200                 205             


Gly Pro Cys Pro Gln Glu Asn Cys Ile Ile Ser Lys Leu Phe Lys Glu 
    210                 215                 220                 


Gly Cys Thr Phe Ile Tyr Asn Ser Thr Gln Asn Ala Thr Ala Ser Ile 
225                 230                 235                 240 


Met Phe Met Gln Ser Leu Ser Ser Val Val Glu Phe Cys Asn Ala Ser 
                245                 250                 255     


Thr His Asn Gln Glu Ala Pro Asn Leu Gln Asn Gln Met Cys Ser Leu 
            260                 265                 270         


Arg Ser Ala Trp Asp Val Ile Thr Asp Ser Ala Asp Phe His His Ser 
        275                 280                 285             


Phe Pro Met Asn Gly Thr Glu Leu Pro Pro Pro Pro Thr Phe Ser Leu 
    290                 295                 300                 


Val Gln Ala Gly Asp Lys Val Val Cys Leu Val Leu Asp Val Ser Ser 
305                 310                 315                 320 


Lys Met Ala Glu Ala Asp Arg Leu Leu Gln Leu Gln Gln Ala Ala Glu 
                325                 330                 335     


Phe Tyr Leu Met Gln Ile Val Glu Ile His Thr Phe Val Gly Ile Ala 
            340                 345                 350         


Ser Phe Asp Ser Lys Gly Glu Ile Arg Ala Gln Leu His Gln Ile Asn 
        355                 360                 365             


Ser Asn Asp Asp Arg Lys Leu Leu Val Ser Tyr Leu Pro Thr Thr Val 
    370                 375                 380                 


Ser Ala Lys Thr Asp Ile Ser Ile Cys Ser Gly Leu Lys Lys Gly Phe 
385                 390                 395                 400 


Glu Val Val Glu Lys Leu Asn Gly Lys Ala Tyr Gly Ser Val Met Ile 
                405                 410                 415     


Leu Val Thr Ser Gly Asp Asp Lys Leu Leu Gly Asn Cys Leu Pro Thr 
            420                 425                 430         


Val Leu Ser Ser Gly Ser Thr Ile His Ser Ile Ala Leu Gly Ser Ser 
        435                 440                 445             


Ala Ala Pro Asn Leu Glu Glu Leu Ser Arg Leu Thr Gly Gly Leu Lys 
    450                 455                 460                 


Phe Phe Val Pro Asp Ile Ser Asn Ser Asn Ser Met Ile Asp Ala Phe 
465                 470                 475                 480 


Ser Arg Ile Ser Ser Gly Thr Gly Asp Ile Phe Gln Gln His Ile Gln 
                485                 490                 495     


Leu Glu Ser Thr Gly Glu Asn Val Lys Pro His His Gln Leu Lys Asn 
            500                 505                 510         


Thr Val Thr Val Asp Asn Thr Val Gly Asn Asp Thr Met Phe Leu Val 
        515                 520                 525             


Thr Trp Gln Ala Ser Gly Pro Pro Glu Ile Ile Leu Phe Asp Pro Asp 
    530                 535                 540                 


Gly Arg Lys Tyr Tyr Thr Asn Asn Phe Ile Thr Asn Leu Thr Phe Arg 
545                 550                 555                 560 


Thr Ala Ser Leu Trp Ile Pro Gly Thr Ala Lys Leu Arg Arg Phe Ala 
                565                 570                 575     


Phe Ile Pro Asp Gly Arg Leu Asn Leu Ser Val Val Asp Phe Asp Thr 
            580                 585                 590         


Leu Ala Leu Phe Leu Phe Leu Ile Tyr Cys Leu Gly His Lys Val Lys 
        595                 600                 605             


Gly Asn Asn Lys Val Tyr Phe His 
    610                 615     


<210>  2230
<211>  868
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCA4__Homo_sapiens__XP_011539317

<400>  2230

Met Glu Asp Met Val Thr Thr Ala Ser Thr Tyr Leu Phe Glu Ala Thr 
1               5                   10                  15      


Glu Lys Arg Phe Phe Phe Lys Asn Val Ser Ile Leu Ile Pro Glu Asn 
            20                  25                  30          


Trp Lys Glu Asn Pro Gln Tyr Lys Arg Pro Lys His Glu Asn His Lys 
        35                  40                  45              


His Ala Asp Val Ile Val Ala Pro Pro Thr Leu Pro Gly Arg Asp Glu 
    50                  55                  60                  


Pro Tyr Thr Lys Gln Phe Thr Glu Cys Gly Glu Lys Gly Glu Tyr Ile 
65                  70                  75                  80  


His Phe Thr Pro Asp Leu Leu Leu Gly Lys Lys Gln Asn Glu Tyr Gly 
                85                  90                  95      


Pro Pro Gly Lys Leu Phe Val His Glu Trp Ala His Leu Arg Trp Gly 
            100                 105                 110         


Val Phe Asp Glu Tyr Asn Glu Asp Gln Pro Phe Tyr Arg Ala Lys Ser 
        115                 120                 125             


Lys Lys Ile Glu Ala Thr Arg Cys Ser Ala Gly Ile Ser Gly Arg Asn 
    130                 135                 140                 


Arg Val Tyr Lys Cys Gln Gly Gly Ser Cys Leu Ser Arg Ala Cys Arg 
145                 150                 155                 160 


Ile Asp Ser Thr Thr Lys Leu Tyr Gly Lys Asp Cys Gln Phe Phe Pro 
                165                 170                 175     


Asp Lys Val Gln Thr Glu Lys Ala Ser Ile Met Phe Met Gln Ser Ile 
            180                 185                 190         


Asp Ser Val Val Glu Phe Cys Asn Glu Lys Thr His Asn Gln Glu Ala 
        195                 200                 205             


Pro Ser Leu Gln Asn Ile Lys Cys Asn Phe Arg Ser Thr Trp Glu Val 
    210                 215                 220                 


Ile Ser Asn Ser Glu Asp Phe Lys Asn Thr Ile Pro Met Val Thr Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Val Phe Ser Leu Leu Lys Ile Ser Gln Arg Ile Val 
                245                 250                 255     


Cys Leu Val Leu Asp Lys Ser Gly Ser Met Gly Gly Lys Asp Arg Leu 
            260                 265                 270         


Asn Arg Met Asn Gln Ala Ala Lys His Phe Leu Leu Gln Thr Val Glu 
        275                 280                 285             


Asn Gly Ser Trp Val Gly Met Val His Phe Asp Ser Thr Ala Thr Ile 
    290                 295                 300                 


Val Asn Lys Leu Ile Gln Ile Lys Ser Ser Asp Glu Arg Asn Thr Leu 
305                 310                 315                 320 


Met Ala Gly Leu Pro Thr Tyr Pro Leu Gly Gly Thr Ser Ile Cys Ser 
                325                 330                 335     


Gly Ile Lys Tyr Ala Phe Gln Val Ile Gly Glu Leu His Ser Gln Leu 
            340                 345                 350         


Asp Gly Ser Glu Val Leu Leu Leu Thr Asp Gly Glu Asp Asn Thr Ala 
        355                 360                 365             


Ser Ser Cys Ile Asp Glu Val Lys Gln Ser Gly Ala Ile Val His Phe 
    370                 375                 380                 


Ile Ala Leu Gly Arg Ala Ala Asp Glu Ala Val Ile Glu Met Ser Lys 
385                 390                 395                 400 


Ile Thr Gly Gly Ser His Phe Tyr Val Ser Asp Glu Ala Gln Asn Asn 
                405                 410                 415     


Gly Leu Ile Asp Ala Phe Gly Ala Leu Thr Ser Gly Asn Thr Asp Leu 
            420                 425                 430         


Ser Gln Lys Ser Leu Gln Leu Glu Ser Lys Gly Leu Thr Leu Asn Ser 
        435                 440                 445             


Asn Ala Trp Met Asn Asp Thr Val Ile Ile Asp Ser Thr Val Gly Lys 
    450                 455                 460                 


Asp Thr Phe Phe Leu Ile Thr Trp Asn Ser Leu Pro Pro Ser Ile Ser 
465                 470                 475                 480 


Leu Trp Asp Pro Ser Gly Thr Ile Met Glu Asn Phe Thr Val Asp Ala 
                485                 490                 495     


Thr Ser Lys Met Ala Tyr Leu Ser Ile Pro Gly Thr Ala Lys Val Gly 
            500                 505                 510         


Thr Trp Ala Tyr Asn Leu Gln Ala Lys Ala Asn Pro Glu Thr Leu Thr 
        515                 520                 525             


Ile Thr Val Thr Ser Arg Ala Ala Asn Ser Ser Val Pro Pro Ile Thr 
    530                 535                 540                 


Val Asn Ala Lys Met Asn Lys Asp Val Asn Ser Phe Pro Ser Pro Met 
545                 550                 555                 560 


Ile Val Tyr Ala Glu Ile Leu Gln Gly Tyr Val Pro Val Leu Gly Ala 
                565                 570                 575     


Asn Val Thr Ala Phe Ile Glu Ser Gln Asn Gly His Thr Glu Val Leu 
            580                 585                 590         


Glu Leu Leu Asp Asn Gly Ala Gly Ala Asp Ser Phe Lys Asn Asp Gly 
        595                 600                 605             


Val Tyr Ser Arg Tyr Phe Thr Ala Tyr Thr Glu Asn Gly Arg Tyr Ser 
    610                 615                 620                 


Leu Lys Val Arg Ala His Gly Gly Ala Asn Thr Ala Arg Leu Lys Leu 
625                 630                 635                 640 


Arg Pro Pro Leu Asn Arg Ala Ala Tyr Ile Pro Gly Trp Val Val Asn 
                645                 650                 655     


Gly Glu Ile Glu Ala Asn Pro Pro Arg Pro Glu Ile Asp Glu Asp Thr 
            660                 665                 670         


Gln Thr Thr Leu Glu Asp Phe Ser Arg Thr Ala Ser Gly Gly Ala Phe 
        675                 680                 685             


Val Val Ser Gln Val Pro Ser Leu Pro Leu Pro Asp Gln Tyr Pro Pro 
    690                 695                 700                 


Ser Gln Ile Thr Asp Leu Asp Ala Thr Val His Glu Asp Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Trp Thr Ala Pro Gly Asp Asn Phe Asp Val Gly Lys Val Gln 
                725                 730                 735     


Arg Tyr Ile Ile Arg Ile Ser Ala Ser Ile Leu Asp Leu Arg Asp Ser 
            740                 745                 750         


Phe Asp Asp Ala Leu Gln Val Asn Thr Thr Asp Leu Ser Pro Lys Glu 
        755                 760                 765             


Ala Asn Ser Lys Glu Ser Phe Ala Phe Lys Pro Glu Asn Ile Ser Glu 
    770                 775                 780                 


Glu Asn Ala Thr His Ile Phe Ile Ala Ile Lys Ser Ile Asp Lys Ser 
785                 790                 795                 800 


Asn Leu Thr Ser Lys Val Ser Asn Ile Ala Gln Val Thr Leu Phe Ile 
                805                 810                 815     


Pro Gln Ala Asn Pro Asp Asp Ile Asp Pro Thr Pro Thr Pro Thr Pro 
            820                 825                 830         


Thr Pro Thr Pro Asp Lys Ser His Asn Ser Gly Val Asn Ile Ser Thr 
        835                 840                 845             


Leu Val Leu Ser Val Ile Gly Ser Val Val Ile Val Asn Phe Ile Leu 
    850                 855                 860                 


Ser Thr Thr Ile 
865             


<210>  2231
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCF1__Homo_sapiens__NP_001159684

<400>  2231

Met Leu Ala Cys Leu Cys Thr Val Leu Trp His Leu Pro Ala Val Pro 
1               5                   10                  15      


Ala Leu Asn Arg Thr Gly Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys 
            20                  25                  30          


Thr Tyr Asp Leu Thr Arg Tyr Leu Glu His Gln Leu Arg Ser Leu Ala 
        35                  40                  45              


Gly Thr Tyr Leu Asn Tyr Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe 
    50                  55                  60                  


Asn Pro Pro Arg Leu Gly Ala Glu Thr Leu Pro Arg Ala Thr Val Asp 
65                  70                  75                  80  


Leu Glu Val Trp Arg Ser Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn 
                85                  90                  95      


Tyr Glu Ala Tyr Ser His Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg 
            100                 105                 110         


Gln Ala Ala Thr Ala Glu Leu Arg Arg Ser Leu Ala His Phe Cys Thr 
        115                 120                 125             


Ser Leu Gln Gly Leu Leu Gly Ser Ile Ala Gly Val Met Ala Ala Leu 
    130                 135                 140                 


Gly Tyr Pro Leu Pro Gln Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr 
145                 150                 155                 160 


Pro Gly Pro Ala His Ser Asp Phe Leu Gln Lys Met Asp Asp Phe Trp 
                165                 170                 175     


Leu Leu Lys Glu Leu Gln Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe 
            180                 185                 190         


Asn Arg Leu Lys Lys Lys Met Gln Pro Pro Ala Ala Ala Val Thr Leu 
        195                 200                 205             


His Leu Gly Ala His Gly Phe 
    210                 215 


<210>  2232
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLC__Homo_sapiens__NP_001819

<400>  2232

Met Ser Leu Leu Pro Val Pro Tyr Thr Glu Ala Ala Ser Leu Ser Thr 
1               5                   10                  15      


Gly Ser Thr Val Thr Ile Lys Gly Arg Pro Leu Ala Cys Phe Leu Asn 
            20                  25                  30          


Glu Pro Tyr Leu Gln Val Asp Phe His Thr Glu Met Lys Glu Glu Ser 
        35                  40                  45              


Asp Ile Val Phe His Phe Gln Val Cys Phe Gly Arg Arg Val Val Met 
    50                  55                  60                  


Asn Ser Arg Glu Tyr Gly Ala Trp Lys Gln Gln Val Glu Ser Lys Asn 
65                  70                  75                  80  


Met Pro Phe Gln Asp Gly Gln Glu Phe Glu Leu Ser Ile Ser Val Leu 
                85                  90                  95      


Pro Asp Lys Tyr Gln Val Met Val Asn Gly Gln Ser Ser Tyr Thr Phe 
            100                 105                 110         


Asp His Arg Ile Lys Pro Glu Ala Val Lys Met Val Gln Val Trp Arg 
        115                 120                 125             


Asp Ile Ser Leu Thr Lys Phe Asn Val Ser Tyr Leu Lys Arg 
    130                 135                 140         


<210>  2233
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCN1__Homo_sapiens__NP_000074

<400>  2233

Met Glu Gln Ser Arg Ser Gln Gln Arg Gly Gly Glu Gln Ser Trp Trp 
1               5                   10                  15      


Gly Ser Asp Pro Gln Tyr Gln Tyr Met Pro Phe Glu His Cys Thr Ser 
            20                  25                  30          


Tyr Gly Leu Pro Ser Glu Asn Gly Gly Leu Gln His Arg Leu Arg Lys 
        35                  40                  45              


Asp Ala Gly Pro Arg His Asn Val His Pro Thr Gln Ile Tyr Gly His 
    50                  55                  60                  


His Lys Glu Gln Phe Ser Asp Arg Glu Gln Asp Ile Gly Met Pro Lys 
65                  70                  75                  80  


Lys Thr Gly Ser Ser Ser Thr Val Asp Ser Lys Asp Glu Asp His Tyr 
                85                  90                  95      


Ser Lys Cys Gln Asp Cys Ile His Arg Leu Gly Gln Val Val Arg Arg 
            100                 105                 110         


Lys Leu Gly Glu Asp Trp Ile Phe Leu Val Leu Leu Gly Leu Leu Met 
        115                 120                 125             


Ala Leu Val Ser Trp Ser Met Asp Tyr Val Ser Ala Lys Ser Leu Gln 
    130                 135                 140                 


Ala Tyr Lys Trp Ser Tyr Ala Gln Met Gln Pro Ser Leu Pro Leu Gln 
145                 150                 155                 160 


Phe Leu Val Trp Val Thr Phe Pro Leu Val Leu Ile Leu Phe Ser Ala 
                165                 170                 175     


Leu Phe Cys His Leu Ile Ser Pro Gln Ala Val Gly Ser Gly Ile Pro 
            180                 185                 190         


Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu Lys Glu Tyr Leu Thr 
        195                 200                 205             


Met Lys Ala Phe Val Ala Lys Val Val Ala Leu Thr Ala Gly Leu Gly 
    210                 215                 220                 


Ser Gly Ile Pro Val Gly Lys Glu Gly Pro Phe Val His Ile Ala Ser 
225                 230                 235                 240 


Ile Cys Ala Ala Val Leu Ser Lys Phe Met Ser Val Phe Cys Gly Val 
                245                 250                 255     


Tyr Glu Gln Pro Tyr Tyr Tyr Ser Asp Ile Leu Thr Val Gly Cys Ala 
            260                 265                 270         


Val Gly Val Gly Cys Cys Phe Gly Thr Pro Leu Gly Gly Val Leu Phe 
        275                 280                 285             


Ser Ile Glu Val Thr Ser Thr Tyr Phe Ala Val Arg Asn Tyr Trp Arg 
    290                 295                 300                 


Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Val Phe Arg Val Leu Ala 
305                 310                 315                 320 


Val Trp Asn Lys Asp Ala Val Thr Ile Thr Ala Leu Phe Arg Thr Asn 
                325                 330                 335     


Phe Arg Met Asp Phe Pro Phe Asp Leu Lys Glu Leu Pro Ala Phe Ala 
            340                 345                 350         


Ala Ile Gly Ile Cys Cys Gly Leu Leu Gly Ala Val Phe Val Tyr Leu 
        355                 360                 365             


His Arg Gln Val Met Leu Gly Val Arg Lys His Lys Ala Leu Ser Gln 
    370                 375                 380                 


Phe Leu Ala Lys His Arg Leu Leu Tyr Pro Gly Ile Val Thr Phe Val 
385                 390                 395                 400 


Ile Ala Ser Phe Thr Phe Pro Pro Gly Met Gly Gln Phe Met Ala Gly 
                405                 410                 415     


Glu Leu Met Pro Arg Glu Ala Ile Ser Thr Leu Phe Asp Asn Asn Thr 
            420                 425                 430         


Trp Val Lys His Ala Gly Asp Pro Glu Ser Leu Gly Gln Ser Ala Val 
        435                 440                 445             


Trp Ile His Pro Arg Val Asn Val Val Ile Ile Ile Phe Leu Phe Phe 
    450                 455                 460                 


Val Met Lys Phe Trp Met Ser Ile Val Ala Thr Thr Met Pro Ile Pro 
465                 470                 475                 480 


Cys Gly Gly Phe Met Pro Val Phe Val Leu Gly Ala Ala Phe Gly Arg 
                485                 490                 495     


Leu Val Gly Glu Ile Met Ala Met Leu Phe Pro Asp Gly Ile Leu Phe 
            500                 505                 510         


Asp Asp Ile Ile Tyr Lys Ile Leu Pro Gly Gly Tyr Ala Val Ile Gly 
        515                 520                 525             


Ala Ala Ala Leu Thr Gly Ala Val Ser His Thr Val Ser Thr Ala Val 
    530                 535                 540                 


Ile Cys Phe Glu Leu Thr Gly Gln Ile Ala His Ile Leu Pro Met Met 
545                 550                 555                 560 


Val Ala Val Ile Leu Ala Asn Met Val Ala Gln Ser Leu Gln Pro Ser 
                565                 570                 575     


Leu Tyr Asp Ser Ile Ile Gln Val Lys Lys Leu Pro Tyr Leu Pro Asp 
            580                 585                 590         


Leu Gly Trp Asn Gln Leu Ser Lys Tyr Thr Ile Phe Val Glu Asp Ile 
        595                 600                 605             


Met Val Arg Asp Val Lys Phe Val Ser Ala Ser Tyr Thr Tyr Gly Glu 
    610                 615                 620                 


Leu Arg Thr Leu Leu Gln Thr Thr Thr Val Lys Thr Leu Pro Leu Val 
625                 630                 635                 640 


Asp Ser Lys Asp Ser Met Ile Leu Leu Gly Ser Val Glu Arg Ser Glu 
                645                 650                 655     


Leu Gln Ala Leu Leu Gln Arg His Leu Cys Pro Glu Arg Arg Leu Arg 
            660                 665                 670         


Ala Ala Gln Glu Met Ala Arg Lys Leu Ser Glu Leu Pro Tyr Asp Gly 
        675                 680                 685             


Lys Ala Arg Leu Ala Gly Glu Gly Leu Pro Gly Ala Pro Pro Gly Arg 
    690                 695                 700                 


Pro Glu Ser Phe Ala Phe Val Asp Glu Asp Glu Asp Glu Asp Leu Ser 
705                 710                 715                 720 


Gly Lys Ser Glu Leu Pro Pro Ser Leu Ala Leu His Pro Ser Thr Thr 
                725                 730                 735     


Ala Pro Leu Ser Pro Glu Glu Pro Asn Gly Pro Leu Pro Gly His Lys 
            740                 745                 750         


Gln Gln Pro Glu Ala Pro Glu Pro Ala Gly Gln Arg Pro Ser Ile Phe 
        755                 760                 765             


Gln Ser Leu Leu His Cys Leu Leu Gly Arg Ala Arg Pro Thr Lys Lys 
    770                 775                 780                 


Lys Thr Thr Gln Asp Ser Thr Asp Leu Val Asp Asn Met Ser Pro Glu 
785                 790                 795                 800 


Glu Ile Glu Ala Trp Glu Gln Glu Gln Leu Ser Gln Pro Val Cys Phe 
                805                 810                 815     


Asp Ser Cys Cys Ile Asp Gln Ser Pro Phe Gln Leu Val Glu Gln Thr 
            820                 825                 830         


Thr Leu His Lys Thr His Thr Leu Phe Ser Leu Leu Gly Leu His Leu 
        835                 840                 845             


Ala Tyr Val Thr Ser Met Gly Lys Leu Arg Gly Val Leu Ala Leu Glu 
    850                 855                 860                 


Glu Leu Gln Lys Ala Ile Glu Gly His Thr Lys Ser Gly Val Gln Leu 
865                 870                 875                 880 


Arg Pro Pro Leu Ala Ser Phe Arg Asn Thr Thr Ser Thr Arg Lys Ser 
                885                 890                 895     


Thr Gly Ala Pro Pro Ser Ser Ala Glu Asn Trp Asn Leu Pro Glu Asp 
            900                 905                 910         


Arg Pro Gly Ala Thr Gly Thr Gly Asp Val Ile Ala Ala Ser Pro Glu 
        915                 920                 925             


Thr Pro Val Pro Ser Pro Ser Pro Glu Pro Pro Leu Ser Leu Ala Pro 
    930                 935                 940                 


Gly Lys Val Glu Gly Glu Leu Glu Glu Leu Glu Leu Val Glu Ser Pro 
945                 950                 955                 960 


Gly Leu Glu Glu Glu Leu Ala Asp Ile Leu Gln Gly Pro Ser Leu Arg 
                965                 970                 975     


Ser Thr Asp Glu Glu Asp Glu Asp Glu Leu Ile Leu 
            980                 985             


<210>  2234
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCN2__Homo_sapiens__NP_001164558

<400>  2234

Met Ala Ala Ala Ala Ala Glu Glu Gly Met Glu Pro Arg Ala Leu Gln 
1               5                   10                  15      


Tyr Glu Gln Thr Leu Met Tyr Gly Arg Tyr Thr Gln Asp Leu Gly Ala 
            20                  25                  30          


Phe Ala Lys Glu Glu Ala Ala Arg Ile Arg Leu Gly Gly Pro Glu Pro 
        35                  40                  45              


Trp Lys Gly Pro Pro Ser Ser Arg Ala Ala Pro Glu Leu Leu Glu Tyr 
    50                  55                  60                  


Gly Arg Ser Arg Cys Ala Arg Cys Arg Val Cys Ser Val Arg Cys His 
65                  70                  75                  80  


Lys Phe Leu Val Ser Arg Val Gly Glu Asp Trp Ile Phe Leu Val Leu 
                85                  90                  95      


Leu Gly Leu Leu Met Ala Leu Val Ser Trp Val Met Asp Tyr Ala Ile 
            100                 105                 110         


Ala Ala Cys Leu Gln Ala Gln Gln Trp Met Ser Arg Gly Leu Asn Thr 
        115                 120                 125             


Ser Ile Leu Leu Gln Tyr Leu Ala Trp Val Thr Tyr Pro Val Val Leu 
    130                 135                 140                 


Ile Thr Phe Ser Ala Gly Phe Thr Gln Ile Leu Ala Pro Gln Ala Val 
145                 150                 155                 160 


Gly Ser Gly Ile Pro Glu Met Lys Thr Ile Leu Arg Gly Val Val Leu 
                165                 170                 175     


Lys Glu Tyr Leu Thr Leu Lys Thr Phe Ile Ala Lys Val Ile Gly Leu 
            180                 185                 190         


Thr Cys Ala Leu Gly Ser Gly Met Pro Leu Gly Lys Glu Gly Pro Phe 
        195                 200                 205             


Val His Ile Ala Ser Met Cys Ala Ala Leu Leu Ser Lys Phe Leu Ser 
    210                 215                 220                 


Leu Phe Gly Gly Ile Tyr Glu Asn Glu Ser Arg Asn Thr Glu Met Leu 
225                 230                 235                 240 


Ala Ala Ala Cys Ala Val Gly Val Gly Cys Cys Phe Ala Ala Pro Ile 
                245                 250                 255     


Gly Gly Val Leu Phe Ser Ile Glu Val Thr Ser Thr Phe Phe Ala Val 
            260                 265                 270         


Arg Asn Tyr Trp Arg Gly Phe Phe Ala Ala Thr Phe Ser Ala Phe Ile 
        275                 280                 285             


Phe Arg Val Leu Ala Val Trp Asn Arg Asp Glu Glu Thr Ile Thr Ala 
    290                 295                 300                 


Leu Phe Lys Thr Arg Phe Arg Leu Asp Phe Pro Phe Asp Leu Gln Glu 
305                 310                 315                 320 


Leu Pro Ala Phe Ala Val Ile Gly Ile Ala Ser Gly Phe Gly Gly Ala 
                325                 330                 335     


Leu Phe Val Tyr Leu Asn Arg Lys Ile Val Gln Val Met Arg Lys Gln 
            340                 345                 350         


Lys Thr Ile Asn Arg Phe Leu Met Arg Lys Arg Leu Leu Phe Pro Ala 
        355                 360                 365             


Leu Val Thr Leu Leu Ile Ser Thr Leu Thr Phe Pro Pro Gly Phe Gly 
    370                 375                 380                 


Gln Phe Met Ala Gly Gln Leu Ser Gln Lys Glu Thr Leu Val Thr Leu 
385                 390                 395                 400 


Phe Asp Asn Arg Thr Trp Val Arg Gln Gly Leu Val Glu Glu Leu Glu 
                405                 410                 415     


Pro Pro Ser Thr Ser Gln Ala Trp Asn Pro Pro Arg Ala Asn Val Phe 
            420                 425                 430         


Leu Thr Leu Val Ile Phe Ile Leu Met Lys Phe Trp Met Ser Ala Leu 
        435                 440                 445             


Ala Thr Thr Ile Pro Val Pro Cys Gly Ala Phe Met Pro Val Phe Val 
    450                 455                 460                 


Ile Asp Gly Ile His Thr Asp Ser Ser Thr Tyr Arg Ile Val Pro Gly 
465                 470                 475                 480 


Gly Tyr Ala Val Val Gly Ala Ala Ala Leu Ala Gly Ala Val Thr His 
                485                 490                 495     


Thr Val Ser Thr Ala Val Ile Val Phe Glu Leu Thr Gly Gln Ile Ala 
            500                 505                 510         


His Ile Leu Pro Val Met Ile Ala Val Ile Leu Ala Asn Ala Val Ala 
        515                 520                 525             


Gln Ser Leu Gln Pro Ser Leu Tyr Asp Ser Ile Ile Arg Ile Lys Lys 
    530                 535                 540                 


Leu Pro Tyr Leu Pro Glu Leu Gly Trp Gly Arg His Gln Gln Tyr Arg 
545                 550                 555                 560 


Val Arg Val Glu Asp Ile Met Val Arg Asp Val Pro His Val Ala Leu 
                565                 570                 575     


Ser Cys Thr Phe Arg Asp Leu Arg Leu Ala Leu His Arg Thr Lys Gly 
            580                 585                 590         


Arg Met Leu Ala Leu Val Glu Ser Pro Glu Ser Met Ile Leu Leu Gly 
        595                 600                 605             


Ser Ile Glu Arg Ser Gln Val Val Ala Leu Leu Gly Ala Gln Leu Ser 
    610                 615                 620                 


Pro Ala Arg Arg Arg Gln His Met Gln Glu Arg Arg Ala Thr Gln Thr 
625                 630                 635                 640 


Ser Pro Leu Ser Asp Gln Glu Gly Pro Pro Thr Pro Glu Ala Ser Val 
                645                 650                 655     


Cys Phe Gln Val Asn Thr Glu Asp Ser Ala Phe Pro Ala Ala Arg Gly 
            660                 665                 670         


Glu Thr His Lys Pro Leu Lys Pro Ala Leu Lys Arg Gly Pro Ser Val 
        675                 680                 685             


Thr Arg Asn Leu Gly Glu Ser Pro Thr Gly Ser Ala Glu Ser Ala Gly 
    690                 695                 700                 


Ile Ala Leu Arg Ser Leu Phe Cys Gly Ser Pro Pro Pro Glu Ala Ala 
705                 710                 715                 720 


Ser Glu Lys Leu Glu Ser Cys Glu Lys Arg Lys Leu Lys Arg Val Arg 
                725                 730                 735     


Ile Ser Leu Ala Ser Asp Ala Asp Leu Glu Gly Glu Met Ser Pro Glu 
            740                 745                 750         


Glu Ile Leu Glu Trp Glu Glu Gln Gln Leu Asp Glu Pro Val Asn Phe 
        755                 760                 765             


Ser Asp Cys Lys Ile Asp Pro Ala Pro Phe Gln Leu Val Glu Arg Thr 
    770                 775                 780                 


Ser Leu His Lys Thr His Thr Ile Phe Ser Leu Leu Gly Val Asp His 
785                 790                 795                 800 


Ala Tyr Val Thr Ser Ile Gly Arg Leu Ile Gly Ile Val Thr Leu Lys 
                805                 810                 815     


Glu Leu Arg Lys Ala Ile Glu Gly Ser Val Thr Ala Gln Gly Val Lys 
            820                 825                 830         


Val Arg Pro Pro Leu Ala Ser Phe Arg Asp Ser Ala Thr Ser Ser Ser 
        835                 840                 845             


Asp Thr Glu Thr Thr Glu Val His Ala Leu Trp Gly Pro His Ser Arg 
    850                 855                 860                 


His Gly Leu Pro Arg Glu Gly Ser Pro Ser Asp Ser Asp Asp Lys Cys 
865                 870                 875                 880 


Gln 
    


<210>  2235
<211>  791
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCN3__Homo_sapiens__NP_001230301

<400>  2235

Met Glu Ser Glu Gln Leu Phe His Arg Gly Tyr Tyr Arg Asn Ser Tyr 
1               5                   10                  15      


Asn Ser Ile Thr Ser Ala Ser Ser Asp Glu Glu Leu Leu Asp Gly Ala 
            20                  25                  30          


Gly Val Ile Met Asp Phe Gln Thr Ser Glu Asp Asp Asn Leu Leu Asp 
        35                  40                  45              


Gly Asp Thr Ala Val Gly Thr His Tyr Thr Met Thr Asn Gly Gly Ser 
    50                  55                  60                  


Ile Asn Ser Ser Thr His Leu Leu Asp Leu Leu Asp Glu Pro Ile Pro 
65                  70                  75                  80  


Gly Val Gly Thr Tyr Asp Asp Phe His Thr Ile Asp Trp Val Arg Glu 
                85                  90                  95      


Lys Cys Lys Asp Arg Glu Arg His Arg Arg Ile Asn Ser Lys Lys Lys 
            100                 105                 110         


Glu Ser Ala Trp Glu Met Thr Lys Ser Leu Tyr Asp Ala Trp Ser Gly 
        115                 120                 125             


Trp Leu Val Val Thr Leu Thr Gly Leu Ala Ser Gly Ala Leu Ala Gly 
    130                 135                 140                 


Leu Ile Asp Ile Ala Ala Asp Trp Met Thr Asp Leu Lys Glu Gly Ile 
145                 150                 155                 160 


Cys Leu Ser Ala Leu Trp Tyr Asn His Glu Gln Cys Cys Trp Gly Ser 
                165                 170                 175     


Asn Glu Thr Thr Phe Glu Glu Arg Asp Lys Cys Pro Gln Trp Lys Thr 
            180                 185                 190         


Trp Ala Glu Leu Ile Ile Gly Gln Ala Glu Gly Pro Gly Ser Tyr Ile 
        195                 200                 205             


Met Asn Tyr Ile Met Tyr Ile Phe Trp Ala Leu Ser Phe Ala Phe Leu 
    210                 215                 220                 


Ala Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly 
225                 230                 235                 240 


Ile Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr 
                245                 250                 255     


Leu Gly Lys Trp Thr Leu Met Ile Lys Thr Ile Thr Leu Val Leu Ala 
            260                 265                 270         


Val Ala Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val 
        275                 280                 285             


Ala Cys Cys Cys Gly Asn Ile Phe Ser Tyr Leu Phe Pro Lys Tyr Ser 
    290                 295                 300                 


Thr Asn Glu Ala Lys Lys Arg Glu Val Ser Tyr Tyr Phe Pro Leu Lys 
305                 310                 315                 320 


Thr Leu Trp Arg Ser Phe Phe Ala Ala Leu Val Ala Ala Phe Val Leu 
                325                 330                 335     


Arg Ser Ile Asn Pro Phe Gly Asn Ser Arg Leu Val Leu Phe Tyr Val 
            340                 345                 350         


Glu Tyr His Thr Pro Trp Tyr Leu Phe Glu Leu Phe Pro Phe Ile Leu 
        355                 360                 365             


Leu Gly Val Phe Gly Gly Leu Trp Gly Ala Phe Phe Ile Arg Ala Asn 
    370                 375                 380                 


Ile Ala Trp Cys Arg Arg Arg Lys Ser Thr Lys Phe Gly Lys Tyr Pro 
385                 390                 395                 400 


Val Leu Glu Val Ile Ile Val Ala Ala Ile Thr Ala Val Ile Ala Phe 
                405                 410                 415     


Pro Asn Pro Tyr Thr Arg Leu Asn Thr Ser Glu Leu Ile Lys Glu Leu 
            420                 425                 430         


Phe Thr Asp Cys Gly Pro Leu Glu Ser Ser Ser Leu Cys Asp Tyr Arg 
        435                 440                 445             


Asn Asp Met Asn Ala Ser Lys Ile Val Asp Asp Ile Pro Asp Arg Pro 
    450                 455                 460                 


Ala Gly Ile Gly Val Tyr Ser Ala Ile Trp Gln Leu Cys Leu Ala Leu 
465                 470                 475                 480 


Ile Phe Lys Ile Ile Met Thr Val Phe Thr Phe Gly Ile Lys Val Pro 
                485                 490                 495     


Ser Gly Leu Phe Ile Pro Ser Met Ala Ile Gly Ala Ile Ala Gly Arg 
            500                 505                 510         


Ile Val Gly Ile Ala Val Glu Gln Leu Ala Tyr Tyr His His Asp Trp 
        515                 520                 525             


Phe Ile Phe Lys Glu Trp Cys Glu Val Gly Ala Asp Cys Ile Thr Pro 
    530                 535                 540                 


Gly Leu Tyr Ala Met Val Gly Ala Ala Ala Cys Leu Gly Gly Val Thr 
545                 550                 555                 560 


Arg Met Thr Val Ser Leu Val Val Ile Val Phe Glu Leu Thr Gly Gly 
                565                 570                 575     


Leu Glu Tyr Ile Val Pro Leu Met Ala Ala Val Met Thr Ser Lys Trp 
            580                 585                 590         


Val Gly Asp Ala Phe Gly Arg Glu Gly Ile Tyr Glu Ala His Ile Arg 
        595                 600                 605             


Leu Asn Gly Tyr Pro Phe Leu Asp Ala Lys Glu Glu Phe Thr His Thr 
    610                 615                 620                 


Thr Leu Ala Ala Asp Val Met Arg Pro Arg Arg Asn Asp Pro Pro Leu 
625                 630                 635                 640 


Ala Val Leu Thr Gln Asp Asn Met Thr Val Asp Asp Ile Glu Asn Met 
                645                 650                 655     


Ile Asn Glu Thr Ser Tyr Asn Gly Phe Pro Val Ile Met Ser Lys Glu 
            660                 665                 670         


Ser Gln Arg Leu Val Gly Phe Ala Leu Arg Arg Asp Leu Thr Ile Ala 
        675                 680                 685             


Ile Glu Ser Ala Arg Lys Lys Gln Glu Gly Ile Val Gly Ser Ser Arg 
    690                 695                 700                 


Val Cys Phe Ala Gln His Thr Pro Ser Leu Pro Ala Glu Ser Pro Arg 
705                 710                 715                 720 


Pro Leu Lys Leu Arg Ser Ile Leu Asp Met Ser Pro Phe Thr Val Thr 
                725                 730                 735     


Asp His Thr Pro Met Glu Ile Val Val Asp Ile Phe Arg Lys Leu Gly 
            740                 745                 750         


Leu Arg Gln Cys Leu Val Thr His Asn Gly Arg Leu Leu Gly Ile Ile 
        755                 760                 765             


Thr Lys Lys Asp Ile Leu Arg His Met Ala Gln Thr Ala Asn Gln Asp 
    770                 775                 780                 


Pro Ala Ser Ile Met Phe Asn 
785                 790     


<210>  2236
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCN4__Homo_sapiens__NP_001243873

<400>  2236

Met Thr Asp Leu Lys Glu Gly Val Cys Leu Ser Ala Phe Trp Tyr Ser 
1               5                   10                  15      


His Glu Gln Cys Cys Trp Thr Ser Asn Glu Thr Thr Phe Glu Asp Arg 
            20                  25                  30          


Asp Lys Cys Pro Leu Trp Gln Lys Trp Ser Glu Leu Leu Val Asn Gln 
        35                  40                  45              


Ser Glu Gly Ala Ser Ala Tyr Ile Leu Asn Tyr Leu Met Tyr Ile Leu 
    50                  55                  60                  


Trp Ala Leu Leu Phe Ala Phe Leu Ala Val Ser Leu Val Arg Val Phe 
65                  70                  75                  80  


Ala Pro Tyr Ala Cys Gly Ser Gly Ile Pro Glu Ile Lys Thr Ile Leu 
                85                  90                  95      


Ser Gly Phe Ile Ile Arg Gly Tyr Leu Gly Lys Trp Thr Leu Leu Ile 
            100                 105                 110         


Lys Thr Val Thr Leu Val Leu Val Val Ser Ser Gly Leu Ser Leu Gly 
        115                 120                 125             


Lys Glu Gly Pro Leu Val His Val Ala Cys Cys Cys Gly Asn Phe Phe 
    130                 135                 140                 


Ser Ser Leu Phe Ser Lys Tyr Ser Lys Asn Glu Gly Lys Arg Arg Glu 
145                 150                 155                 160 


Val Leu Ser Ala Ala Ala Ala Ala Gly Val Ser Val Ala Phe Gly Ala 
                165                 170                 175     


Pro Ile Gly Gly Val Leu Phe Ser Leu Glu Glu Val Ser Tyr Tyr Phe 
            180                 185                 190         


Pro Leu Lys Thr Leu Trp Arg Ser Phe Phe Ala Ala Leu Val Ala Ala 
        195                 200                 205             


Phe Thr Leu Arg Ser Ile Asn Pro Phe Gly Asn Ser Arg Leu Val Leu 
    210                 215                 220                 


Phe Tyr Val Glu Tyr His Thr Pro Trp Tyr Met Ala Glu Leu Phe Pro 
225                 230                 235                 240 


Phe Ile Leu Leu Gly Val Phe Gly Gly Leu Trp Gly Thr Leu Phe Ile 
                245                 250                 255     


Arg Cys Asn Ile Ala Trp Cys Arg Arg Arg Lys Thr Thr Arg Leu Gly 
            260                 265                 270         


Lys Tyr Pro Val Leu Glu Val Ile Val Val Thr Ala Ile Thr Ala Ile 
        275                 280                 285             


Ile Ala Tyr Pro Asn Pro Tyr Thr Arg Gln Ser Thr Ser Glu Leu Ile 
    290                 295                 300                 


Ser Glu Leu Phe Asn Asp Cys Gly Ala Leu Glu Ser Ser Gln Leu Cys 
305                 310                 315                 320 


Asp Tyr Ile Asn Asp Pro Asn Met Thr Arg Pro Val Asp Asp Ile Pro 
                325                 330                 335     


Asp Arg Pro Ala Gly Val Gly Val Tyr Thr Ala Met Trp Gln Leu Ala 
            340                 345                 350         


Leu Ala Leu Ile Phe Lys Ile Val Val Thr Ile Phe Thr Phe Gly Met 
        355                 360                 365             


Lys Ile Pro Ser Gly Leu Phe Ile Pro Ser Met Ala Val Gly Ala Ile 
    370                 375                 380                 


Ala Gly Arg Met Val Gly Ile Gly Val Glu Gln Leu Ala Tyr His His 
385                 390                 395                 400 


His Asp Trp Ile Ile Phe Arg Asn Trp Cys Arg Pro Gly Ala Asp Cys 
                405                 410                 415     


Val Thr Pro Gly Leu Tyr Ala Met Val Gly Ala Ala Ala Cys Leu Gly 
            420                 425                 430         


Gly Val Thr Arg Met Thr Val Ser Leu Val Val Ile Met Phe Glu Leu 
        435                 440                 445             


Thr Gly Gly Leu Glu Tyr Ile Val Pro Leu Met Ala Ala Ala Val Thr 
    450                 455                 460                 


Ser Lys Trp Val Ala Asp Ala Phe Gly Lys Glu Gly Ile Tyr Glu Ala 
465                 470                 475                 480 


His Ile His Leu Asn Gly Tyr Pro Phe Leu Asp Val Lys Asp Glu Phe 
                485                 490                 495     


Thr His Arg Thr Leu Ala Thr Asp Val Met Arg Pro Arg Arg Gly Glu 
            500                 505                 510         


Pro Pro Leu Ser Val Leu Thr Gln Asp Ser Met Thr Val Glu Asp Val 
        515                 520                 525             


Glu Thr Leu Ile Lys Glu Thr Asp Tyr Asn Gly Phe Pro Val Val Val 
    530                 535                 540                 


Ser Arg Asp Ser Glu Arg Leu Ile Gly Phe Ala Gln Arg Arg Glu Leu 
545                 550                 555                 560 


Ile Leu Ala Ile Lys Asn Ala Arg Gln Arg Gln Glu Gly Ile Val Ser 
                565                 570                 575     


Asn Ser Ile Met Tyr Phe Thr Glu Glu Pro Pro Glu Leu Pro Ala Asn 
            580                 585                 590         


Ser Pro His Pro Leu Lys Leu Arg Arg Ile Leu Asn Leu Ser Pro Phe 
        595                 600                 605             


Thr Val Thr Asp His Thr Pro Met Glu Thr Val Val Asp Ile Phe Arg 
    610                 615                 620                 


Lys Leu Gly Leu Arg Gln Cys Leu Val Thr Arg Ser Gly Arg Leu Leu 
625                 630                 635                 640 


Gly Ile Ile Thr Lys Lys Asp Val Leu Arg His Met Ala Gln Met Ala 
                645                 650                 655     


Asn Gln Asp Pro Glu Ser Ile Met Phe Asn 
            660                 665     


<210>  2237
<211>  816
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCN5__Homo_sapiens__NP_001121370

<400>  2237

Met Ala Met Trp Gln Gly Ala Met Asp Asn Arg Gly Phe Gln Gln Gly 
1               5                   10                  15      


Ser Phe Ser Ser Phe Gln Asn Ser Ser Ser Asp Glu Asp Leu Met Asp 
            20                  25                  30          


Ile Pro Ala Thr Ala Met Asp Phe Ser Met Arg Asp Asp Val Pro Pro 
        35                  40                  45              


Leu Asp Arg Glu Val Gly Glu Asp Lys Ser Tyr Asn Gly Gly Gly Ile 
    50                  55                  60                  


Gly Ser Ser Asn Arg Ile Met Asp Phe Leu Glu Glu Pro Ile Pro Gly 
65                  70                  75                  80  


Val Gly Thr Tyr Asp Asp Phe Asn Thr Ile Asp Trp Val Arg Glu Lys 
                85                  90                  95      


Ser Arg Asp Arg Asp Arg His Arg Glu Ile Thr Asn Lys Ser Lys Glu 
            100                 105                 110         


Ser Thr Trp Ala Leu Ile His Ser Val Ser Asp Ala Phe Ser Gly Trp 
        115                 120                 125             


Leu Leu Met Leu Leu Ile Gly Leu Leu Ser Gly Ser Leu Ala Gly Leu 
    130                 135                 140                 


Ile Asp Ile Ser Ala His Trp Met Thr Asp Leu Lys Glu Gly Ile Cys 
145                 150                 155                 160 


Thr Gly Gly Phe Trp Phe Asn His Glu His Cys Cys Trp Asn Ser Glu 
                165                 170                 175     


His Val Thr Phe Glu Glu Arg Asp Lys Cys Pro Glu Trp Asn Ser Trp 
            180                 185                 190         


Ser Gln Leu Ile Ile Ser Thr Asp Glu Gly Ala Phe Ala Tyr Ile Val 
        195                 200                 205             


Asn Tyr Phe Met Tyr Val Leu Trp Ala Leu Leu Phe Ala Phe Leu Ala 
    210                 215                 220                 


Val Ser Leu Val Lys Val Phe Ala Pro Tyr Ala Cys Gly Ser Gly Ile 
225                 230                 235                 240 


Pro Glu Ile Lys Thr Ile Leu Ser Gly Phe Ile Ile Arg Gly Tyr Leu 
                245                 250                 255     


Gly Lys Trp Thr Leu Val Ile Lys Thr Ile Thr Leu Val Leu Ala Val 
            260                 265                 270         


Ser Ser Gly Leu Ser Leu Gly Lys Glu Gly Pro Leu Val His Val Ala 
        275                 280                 285             


Cys Cys Cys Gly Asn Ile Leu Cys His Cys Phe Asn Lys Tyr Arg Lys 
    290                 295                 300                 


Asn Glu Ala Lys Arg Arg Glu Val Leu Ser Ala Ala Ala Ala Ala Gly 
305                 310                 315                 320 


Val Ser Val Ala Phe Gly Ala Pro Ile Gly Gly Val Leu Phe Ser Leu 
                325                 330                 335     


Glu Glu Val Ser Tyr Tyr Phe Pro Leu Lys Thr Leu Trp Arg Ser Phe 
            340                 345                 350         


Phe Ala Ala Leu Val Ala Ala Phe Thr Leu Arg Ser Ile Asn Pro Phe 
        355                 360                 365             


Gly Asn Ser Arg Leu Val Leu Phe Tyr Val Glu Phe His Thr Pro Trp 
    370                 375                 380                 


His Leu Phe Glu Leu Val Pro Phe Ile Leu Leu Gly Ile Phe Gly Gly 
385                 390                 395                 400 


Leu Trp Gly Ala Leu Phe Ile Arg Thr Asn Ile Ala Trp Cys Arg Lys 
                405                 410                 415     


Arg Lys Thr Thr Gln Leu Gly Lys Tyr Pro Val Ile Glu Val Leu Val 
            420                 425                 430         


Val Thr Ala Ile Thr Ala Ile Leu Ala Phe Pro Asn Glu Tyr Thr Arg 
        435                 440                 445             


Met Ser Thr Ser Glu Leu Ile Ser Glu Leu Phe Asn Asp Cys Gly Leu 
    450                 455                 460                 


Leu Asp Ser Ser Lys Leu Cys Asp Tyr Glu Asn Arg Phe Asn Thr Ser 
465                 470                 475                 480 


Lys Gly Gly Glu Leu Pro Asp Arg Pro Ala Gly Val Gly Val Tyr Ser 
                485                 490                 495     


Ala Met Trp Gln Leu Ala Leu Thr Leu Ile Leu Lys Ile Val Ile Thr 
            500                 505                 510         


Ile Phe Thr Phe Gly Met Lys Ile Pro Ser Gly Leu Phe Ile Pro Ser 
        515                 520                 525             


Met Ala Val Gly Ala Ile Ala Gly Arg Leu Leu Gly Val Gly Met Glu 
    530                 535                 540                 


Gln Leu Ala Tyr Tyr His Gln Glu Trp Thr Val Phe Asn Ser Trp Cys 
545                 550                 555                 560 


Ser Gln Gly Ala Asp Cys Ile Thr Pro Gly Leu Tyr Ala Met Val Gly 
                565                 570                 575     


Ala Ala Ala Cys Leu Gly Gly Val Thr Arg Met Thr Val Ser Leu Val 
            580                 585                 590         


Val Ile Met Phe Glu Leu Thr Gly Gly Leu Glu Tyr Ile Val Pro Leu 
        595                 600                 605             


Met Ala Ala Ala Met Thr Ser Lys Trp Val Ala Asp Ala Leu Gly Arg 
    610                 615                 620                 


Glu Gly Ile Tyr Asp Ala His Ile Arg Leu Asn Gly Tyr Pro Phe Leu 
625                 630                 635                 640 


Glu Ala Lys Glu Glu Phe Ala His Lys Thr Leu Ala Met Asp Val Met 
                645                 650                 655     


Lys Pro Arg Arg Asn Asp Pro Leu Leu Thr Val Leu Thr Gln Asp Ser 
            660                 665                 670         


Met Thr Val Glu Asp Val Glu Thr Ile Ile Ser Glu Thr Thr Tyr Ser 
        675                 680                 685             


Gly Phe Pro Val Val Val Ser Arg Glu Ser Gln Arg Leu Val Gly Phe 
    690                 695                 700                 


Val Leu Arg Arg Asp Leu Ile Ile Ser Ile Glu Asn Ala Arg Lys Lys 
705                 710                 715                 720 


Gln Asp Gly Val Val Ser Thr Ser Ile Ile Tyr Phe Thr Glu His Ser 
                725                 730                 735     


Pro Pro Leu Pro Pro Tyr Thr Pro Pro Thr Leu Lys Leu Arg Asn Ile 
            740                 745                 750         


Leu Asp Leu Ser Pro Phe Thr Val Thr Asp Leu Thr Pro Met Glu Ile 
        755                 760                 765             


Val Val Asp Ile Phe Arg Lys Leu Gly Leu Arg Gln Cys Leu Val Thr 
    770                 775                 780                 


His Asn Gly Arg Leu Leu Gly Ile Ile Thr Lys Lys Asp Val Leu Lys 
785                 790                 795                 800 


His Ile Ala Gln Met Ala Asn Gln Asp Pro Asp Ser Ile Leu Phe Asn 
                805                 810                 815     


<210>  2238
<211>  869
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCN6__Homo_sapiens__NP_001277

<400>  2238

Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu 
            20                  25                  30          


Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ser Leu Asp Tyr Asp Arg Cys Ile Asn Asp Pro Tyr Leu Glu Val 
    50                  55                  60                  


Leu Glu Thr Met Asp Asn Lys Lys Gly Arg Arg Tyr Glu Ala Val Lys 
65                  70                  75                  80  


Trp Met Val Val Phe Ala Ile Gly Val Cys Thr Gly Leu Val Gly Leu 
                85                  90                  95      


Phe Val Asp Phe Phe Val Arg Leu Phe Thr Gln Leu Lys Phe Gly Val 
            100                 105                 110         


Val Gln Thr Ser Val Glu Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu 
        115                 120                 125             


Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Thr Phe Val Phe Leu Ala 
    130                 135                 140                 


Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro 
145                 150                 155                 160 


Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro Gly Ile Val Arg 
                165                 170                 175     


Leu Arg Thr Leu Leu Cys Lys Val Leu Gly Val Leu Phe Ser Val Ala 
            180                 185                 190         


Gly Gly Leu Phe Val Gly Lys Glu Gly Pro Met Ile His Ser Gly Ser 
        195                 200                 205             


Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys 
    210                 215                 220                 


Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp 
225                 230                 235                 240 


Phe Val Ser Ala Gly Ala Ala Ala Gly Val Ala Ala Ala Phe Gly Ala 
                245                 250                 255     


Pro Ile Gly Gly Thr Leu Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp 
            260                 265                 270         


Asn Gln Gly Leu Thr Trp Lys Val Leu Phe Cys Ser Met Ser Ala Thr 
        275                 280                 285             


Phe Thr Leu Asn Phe Phe Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly 
    290                 295                 300                 


Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser 
305                 310                 315                 320 


Asp Ser Asp Lys Lys Cys His Leu Trp Thr Ala Met Asp Leu Gly Phe 
                325                 330                 335     


Phe Val Val Met Gly Val Ile Gly Gly Leu Leu Gly Ala Thr Phe Asn 
            340                 345                 350         


Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg Met Arg Asn Val His Pro 
        355                 360                 365             


Lys Pro Lys Leu Val Arg Val Leu Glu Ser Leu Leu Val Ser Leu Val 
    370                 375                 380                 


Thr Thr Val Val Val Phe Val Ala Ser Met Val Leu Gly Glu Cys Arg 
385                 390                 395                 400 


Gln Met Ser Ser Ser Ser Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln 
                405                 410                 415     


Val Thr Glu Asp Val Asn Ser Ser Ile Lys Thr Phe Phe Cys Pro Asn 
            420                 425                 430         


Asp Thr Tyr Asn Asp Met Ala Thr Leu Phe Phe Asn Pro Gln Glu Ser 
        435                 440                 445             


Ala Ile Leu Gln Leu Phe His Gln Asp Gly Thr Phe Ser Pro Val Thr 
    450                 455                 460                 


Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu Leu Ala Cys Trp Thr Tyr 
465                 470                 475                 480 


Gly Ile Ser Val Pro Ser Gly Leu Phe Val Pro Ser Leu Leu Cys Gly 
                485                 490                 495     


Ala Ala Phe Gly Arg Leu Val Ala Asn Val Leu Lys Ser Tyr Ile Gly 
            500                 505                 510         


Leu Gly His Ile Tyr Ser Gly Thr Phe Ala Leu Ile Gly Ala Ala Ala 
        515                 520                 525             


Phe Leu Gly Gly Val Val Arg Met Thr Ile Ser Leu Thr Val Ile Leu 
    530                 535                 540                 


Ile Glu Ser Thr Asn Glu Ile Thr Tyr Gly Leu Pro Ile Met Val Thr 
545                 550                 555                 560 


Leu Met Val Ala Lys Trp Thr Gly Asp Phe Phe Asn Lys Gly Ile Tyr 
                565                 570                 575     


Asp Ile His Val Gly Leu Arg Gly Val Pro Leu Leu Glu Trp Glu Thr 
            580                 585                 590         


Glu Val Glu Met Asp Lys Leu Arg Ala Ser Asp Ile Met Glu Pro Asn 
        595                 600                 605             


Leu Thr Tyr Val Tyr Pro His Thr Arg Ile Gln Ser Leu Val Ser Ile 
    610                 615                 620                 


Leu Arg Thr Thr Val His His Ala Phe Pro Val Val Thr Glu Asn Arg 
625                 630                 635                 640 


Gly Asn Glu Lys Glu Phe Met Lys Gly Asn Gln Leu Ile Ser Asn Asn 
                645                 650                 655     


Ile Lys Phe Lys Lys Ser Ser Ile Leu Thr Arg Ala Gly Glu Gln Arg 
            660                 665                 670         


Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn 
        675                 680                 685             


Met Cys Asp Glu His Ile Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp 
    690                 695                 700                 


Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr Thr Pro Tyr Pro Asn Leu 
705                 710                 715                 720 


Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp Thr Met Glu Glu Arg Phe 
                725                 730                 735     


Arg Pro Leu Thr Phe His Gly Leu Ile Leu Arg Ser Gln Leu Val Thr 
            740                 745                 750         


Leu Leu Val Arg Gly Val Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser 
        755                 760                 765             


Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr 
    770                 775                 780                 


Pro Asp Ile His Asp Leu Asp Leu Thr Leu Leu Asn Pro Arg Met Ile 
785                 790                 795                 800 


Val Asp Val Thr Pro Tyr Met Asn Pro Ser Pro Phe Thr Val Ser Pro 
                805                 810                 815     


Asn Thr His Val Ser Gln Val Phe Asn Leu Phe Arg Thr Met Gly Leu 
            820                 825                 830         


Arg His Leu Pro Val Val Asn Ala Val Gly Glu Ile Val Gly Ile Ile 
        835                 840                 845             


Thr Arg His Asn Leu Thr Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln 
    850                 855                 860                 


His Tyr Gln Thr Ile 
865                 


<210>  2239
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCN7__Homo_sapiens__NP_001107803

<400>  2239

Met Ala Asn Val Ser Lys Lys Val Ser Trp Ser Gly Arg Asp Arg Asp 
1               5                   10                  15      


Asp Glu Glu Ala Ala Pro Leu Leu Arg Arg Thr Ala Arg Pro Gly Gly 
            20                  25                  30          


Gly Thr Pro Leu Leu Asn Gly Ala Gly Pro Gly Ala Ala Arg Gln Asp 
        35                  40                  45              


Met Asp Pro Pro His Pro Phe Pro Lys Glu Ile Pro His Asn Glu Lys 
    50                  55                  60                  


Leu Leu Ser Leu Lys Tyr Glu Ser Leu Asp Tyr Asp Asn Ser Glu Asn 
65                  70                  75                  80  


Gln Leu Phe Leu Glu Glu Glu Arg Arg Ile Asn His Thr Ala Phe Arg 
                85                  90                  95      


Thr Val Glu Ile Lys Arg Trp Val Ile Cys Ala Leu Ile Gly Ile Leu 
            100                 105                 110         


Thr Gly Leu Val Ala Cys Phe Ile Asp Ile Val Val Glu Asn Leu Ala 
        115                 120                 125             


Gly Leu Lys Tyr Arg Val Ile Lys Gly Asn Ile Asp Lys Phe Thr Glu 
    130                 135                 140                 


Lys Gly Gly Leu Ser Phe Ser Leu Leu Leu Trp Ala Thr Leu Asn Ala 
145                 150                 155                 160 


Ala Phe Val Leu Val Gly Ser Val Ile Val Ala Phe Ile Glu Pro Val 
                165                 170                 175     


Ala Ala Gly Ser Gly Ile Pro Gln Ile Lys Cys Phe Leu Asn Gly Val 
            180                 185                 190         


Lys Ile Pro His Val Val Arg Leu Lys Thr Leu Val Ile Lys Val Ser 
        195                 200                 205             


Gly Val Ile Leu Ser Val Val Gly Gly Leu Ala Val Gly Lys Glu Gly 
    210                 215                 220                 


Pro Met Ile His Ser Gly Ser Val Ile Ala Ala Gly Ile Ser Gln Gly 
225                 230                 235                 240 


Arg Ser Thr Ser Leu Lys Arg Asp Phe Lys Ile Phe Glu Tyr Phe Arg 
                245                 250                 255     


Arg Asp Thr Glu Lys Arg Asp Phe Val Ser Ala Gly Ala Ala Ala Gly 
            260                 265                 270         


Val Ser Ala Ala Phe Gly Ala Pro Val Gly Gly Val Leu Phe Ser Leu 
        275                 280                 285             


Glu Glu Gly Ala Ser Phe Trp Asn Gln Phe Leu Thr Trp Arg Ile Phe 
    290                 295                 300                 


Phe Ala Ser Met Ile Ser Thr Phe Thr Leu Asn Phe Val Leu Ser Ile 
305                 310                 315                 320 


Tyr His Gly Asn Met Trp Asp Leu Ser Ser Pro Gly Leu Ile Asn Phe 
                325                 330                 335     


Gly Arg Phe Asp Ser Glu Lys Met Ala Tyr Thr Ile His Glu Ile Pro 
            340                 345                 350         


Val Phe Ile Ala Met Gly Val Val Gly Gly Val Leu Gly Ala Val Phe 
        355                 360                 365             


Asn Ala Leu Asn Tyr Trp Leu Thr Met Phe Arg Ile Arg Tyr Ile His 
    370                 375                 380                 


Arg Pro Cys Leu Gln Val Ile Glu Ala Val Leu Val Ala Ala Val Thr 
385                 390                 395                 400 


Ala Thr Val Ala Phe Val Leu Ile Tyr Ser Ser Arg Asp Cys Gln Pro 
                405                 410                 415     


Leu Gln Gly Gly Ser Met Ser Tyr Pro Leu Gln Leu Phe Cys Ala Asp 
            420                 425                 430         


Gly Glu Tyr Asn Ser Met Ala Ala Ala Phe Phe Asn Thr Pro Glu Lys 
        435                 440                 445             


Ser Val Val Ser Leu Phe His Asp Pro Pro Gly Ser Tyr Asn Pro Leu 
    450                 455                 460                 


Thr Leu Gly Leu Phe Thr Leu Val Tyr Phe Phe Leu Ala Cys Trp Thr 
465                 470                 475                 480 


Tyr Gly Leu Thr Val Ser Ala Gly Val Phe Ile Pro Ser Leu Leu Ile 
                485                 490                 495     


Gly Ala Ala Trp Gly Arg Leu Phe Gly Ile Ser Leu Ser Tyr Leu Thr 
            500                 505                 510         


Gly Ala Ala Ile Trp Ala Asp Pro Gly Lys Tyr Ala Leu Met Gly Ala 
        515                 520                 525             


Ala Ala Gln Leu Gly Gly Ile Val Arg Met Thr Leu Ser Leu Thr Val 
    530                 535                 540                 


Ile Met Met Glu Ala Thr Ser Asn Val Thr Tyr Gly Phe Pro Ile Met 
545                 550                 555                 560 


Leu Val Leu Met Thr Ala Lys Ile Val Gly Asp Val Phe Ile Glu Gly 
                565                 570                 575     


Leu Tyr Asp Met His Ile Gln Leu Gln Ser Val Pro Phe Leu His Trp 
            580                 585                 590         


Glu Ala Pro Val Thr Ser His Ser Leu Thr Ala Arg Glu Val Met Ser 
        595                 600                 605             


Thr Pro Val Thr Cys Leu Arg Arg Arg Glu Lys Val Gly Val Ile Val 
    610                 615                 620                 


Asp Val Leu Ser Asp Thr Ala Ser Asn His Asn Gly Phe Pro Val Val 
625                 630                 635                 640 


Glu His Ala Asp Asp Thr Gln Pro Ala Arg Leu Gln Gly Leu Ile Leu 
                645                 650                 655     


Arg Ser Gln Leu Ile Val Leu Leu Lys His Lys Val Phe Val Glu Arg 
            660                 665                 670         


Ser Asn Leu Gly Leu Val Gln Arg Arg Leu Arg Leu Lys Asp Phe Arg 
        675                 680                 685             


Asp Ala Tyr Pro Arg Phe Pro Pro Ile Gln Ser Ile His Val Ser Gln 
    690                 695                 700                 


Asp Glu Arg Glu Cys Thr Met Asp Leu Ser Glu Phe Met Asn Pro Ser 
705                 710                 715                 720 


Pro Tyr Thr Val Pro Gln Glu Ala Ser Leu Pro Arg Val Phe Lys Leu 
                725                 730                 735     


Phe Arg Ala Leu Gly Leu Arg His Leu Val Val Val Asp Asn Arg Asn 
            740                 745                 750         


Gln Val Val Gly Leu Val Thr Arg Lys Asp Leu Ala Arg Tyr Arg Leu 
        755                 760                 765             


Gly Lys Arg Gly Leu Glu Glu Leu Ser Leu Ala Gln Thr 
    770                 775                 780     


<210>  2240
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLCNKB__Homo_sapiens__XP_011538921

<400>  2240

Met Thr Leu Gly Val Leu Met Ala Leu Val Ser Cys Ala Met Asp Leu 
1               5                   10                  15      


Ala Val Glu Ser Val Val Arg Ala His Gln Trp Leu Tyr Arg Glu Ile 
            20                  25                  30          


Gly Asp Ser His Leu Leu Arg Tyr Leu Ser Trp Thr Val Tyr Pro Val 
        35                  40                  45              


Ala Leu Val Ser Phe Ser Ser Gly Phe Ser Gln Ser Ile Thr Pro Ser 
    50                  55                  60                  


Ser Gly Gly Ser Gly Ile Pro Glu Val Lys Thr Met Leu Ala Gly Val 
65                  70                  75                  80  


Val Leu Glu Asp Tyr Leu Asp Ile Lys Asn Phe Gly Ala Lys Val Val 
                85                  90                  95      


Gly Leu Ser Cys Thr Leu Ala Cys Gly Ser Thr Leu Phe Leu Gly Lys 
            100                 105                 110         


Val Gly Pro Phe Val His Leu Ser Val Met Met Ala Ala Tyr Leu Gly 
        115                 120                 125             


Arg Val Arg Thr Thr Thr Ile Gly Glu Pro Glu Asn Lys Ser Lys Gln 
    130                 135                 140                 


Asn Glu Met Leu Val Ala Ala Ala Ala Val Gly Val Ala Thr Val Phe 
145                 150                 155                 160 


Ala Ala Pro Phe Ser Gly Val Leu Phe Ser Ile Glu Val Met Ser Ser 
                165                 170                 175     


His Phe Ser Val Trp Asp Tyr Trp Arg Gly Phe Phe Ala Ala Thr Cys 
            180                 185                 190         


Gly Ala Phe Met Phe Arg Leu Leu Ala Val Phe Asn Ser Glu Gln Glu 
        195                 200                 205             


Thr Ile Thr Ser Leu Tyr Lys Thr Ser Phe Arg Val Asp Val Pro Phe 
    210                 215                 220                 


Asp Leu Pro Glu Ile Phe Phe Phe Val Ala Leu Gly Gly Leu Cys Gly 
225                 230                 235                 240 


Ile Leu Gly Ser Ala Tyr Leu Phe Cys Gln Arg Ile Phe Phe Gly Phe 
                245                 250                 255     


Ile Arg Asn Asn Arg Phe Ser Ser Lys Leu Leu Ala Thr Ser Lys Pro 
            260                 265                 270         


Val Tyr Ser Ala Leu Ala Thr Leu Val Leu Ala Ser Ile Thr Tyr Pro 
        275                 280                 285             


Pro Ser Ala Gly Arg Phe Leu Ala Ser Arg Leu Ser Met Lys Gln His 
    290                 295                 300                 


Leu Asp Ser Leu Phe Asp Asn His Ser Trp Ala Leu Met Thr Gln Asn 
305                 310                 315                 320 


Ser Ser Pro Pro Trp Pro Glu Glu Leu Asp Pro Gln His Leu Trp Trp 
                325                 330                 335     


Glu Trp Tyr His Pro Arg Phe Thr Ile Phe Gly Thr Leu Ala Phe Phe 
            340                 345                 350         


Leu Val Met Lys Phe Trp Met Leu Ile Leu Ala Thr Thr Ile Pro Met 
        355                 360                 365             


Pro Ala Gly Tyr Phe Met Pro Ile Phe Val Tyr Gly Ala Ala Ile Gly 
    370                 375                 380                 


Arg Leu Phe Gly Glu Thr Leu Ser Phe Ile Phe Pro Glu Gly Ile Val 
385                 390                 395                 400 


Ala Gly Gly Ile Thr Asn Pro Ile Met Pro Gly Gly Tyr Ala Leu Ala 
                405                 410                 415     


Gly Ala Ala Ala Phe Ser Gly Ala Val Thr His Thr Ile Ser Thr Ala 
            420                 425                 430         


Leu Leu Ala Phe Glu Val Thr Gly Gln Ile Val His Ala Leu Pro Val 
        435                 440                 445             


Leu Met Ala Val Leu Ala Ala Asn Ala Ile Ala Gln Ser Cys Gln Pro 
    450                 455                 460                 


Ser Phe Tyr Asp Gly Thr Val Ile Val Lys Lys Leu Pro Tyr Leu Pro 
465                 470                 475                 480 


Arg Ile Leu Gly Arg Asn Ile Gly Ser His Arg Val Arg Val Glu His 
                485                 490                 495     


Phe Met Asn His Ser Ile Thr Thr Leu Ala Lys Asp Met Pro Leu Glu 
            500                 505                 510         


Glu Val Val Lys Val Val Thr Ser Thr Asp Val Ala Lys Tyr Pro Leu 
        515                 520                 525             


Val Glu Ser Thr Glu Ser Gln Ile Leu Val Gly Ile Val Arg Arg Ala 
    530                 535                 540                 


Gln Leu Val Gln Ala Leu Lys Ala Glu Pro Pro Ser Trp Ala Pro Gly 
545                 550                 555                 560 


His Gln Gln Cys Leu Gln Asp Ile Leu Ala Ala Gly Cys Pro Thr Glu 
                565                 570                 575     


Pro Val Thr Leu Lys Leu Ser Pro Glu Thr Ser Leu His Glu Ala His 
            580                 585                 590         


Asn Leu Phe Glu Leu Leu Asn Leu His Ser Leu Phe Val Thr Ser Arg 
        595                 600                 605             


Gly Arg Ala Val Gly Cys Val Ser Trp Val Glu Met Lys Lys Ala Ile 
    610                 615                 620                 


Ser Asn Leu Thr Asn Pro Pro Ala Pro Lys 
625                 630                 


<210>  2241
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN10__Homo_sapiens__NP_001153572

<400>  2241

Met Ser Arg Ala Gln Ile Trp Ala Leu Val Ser Gly Val Gly Gly Phe 
1               5                   10                  15      


Gly Ala Leu Val Ala Ala Thr Thr Ser Asn Glu Trp Lys Val Thr Thr 
            20                  25                  30          


Arg Ala Ser Ser Val Ile Thr Ala Thr Trp Val Tyr Gln Gly Leu Trp 
        35                  40                  45              


Met Asn Cys Ala Gly Tyr Ile Gln Ala Cys Arg Gly Leu Met Ile Ala 
    50                  55                  60                  


Ala Val Ser Leu Gly Phe Phe Gly Ser Ile Phe Ala Leu Phe Gly Met 
65                  70                  75                  80  


Lys Cys Thr Lys Val Gly Gly Ser Asp Lys Ala Lys Ala Lys Ile Ala 
                85                  90                  95      


Cys Leu Ala Gly Ile Val Phe Ile Leu Ser Gly Leu Cys Ser Met Thr 
            100                 105                 110         


Gly Cys Ser Leu Tyr Ala Asn Lys Ile Thr Thr Glu Phe Phe Asp Pro 
        115                 120                 125             


Leu Phe Val Glu Gln Lys Tyr Glu Leu Gly Ala Ala Leu Phe Ile Gly 
    130                 135                 140                 


Trp Ala Gly Ala Ser Leu Cys Ile Ile Gly Gly Val Ile Phe Cys Phe 
145                 150                 155                 160 


Ser Ile Ser Asp Asn Asn Lys Thr Pro Arg Tyr Thr Tyr Asn Gly Ala 
                165                 170                 175     


Thr Ser Val Met Ser Ser Arg Thr Lys Tyr His Gly Gly Glu Asp Phe 
            180                 185                 190         


Lys Thr Thr Asn Pro Ser Lys Gln Phe Asp Lys Asn Ala Tyr Val 
        195                 200                 205         


<210>  2242
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN11__Homo_sapiens__NP_005593

<400>  2242

Met Val Ala Thr Cys Leu Gln Val Val Gly Phe Val Thr Ser Phe Val 
1               5                   10                  15      


Gly Trp Ile Gly Val Ile Val Thr Thr Ser Thr Asn Asp Trp Val Val 
            20                  25                  30          


Thr Cys Gly Tyr Thr Ile Pro Thr Cys Arg Lys Leu Asp Glu Leu Gly 
        35                  40                  45              


Ser Lys Gly Leu Trp Ala Asp Cys Val Met Ala Thr Gly Leu Tyr His 
    50                  55                  60                  


Cys Lys Pro Leu Val Asp Ile Leu Ile Leu Pro Gly Tyr Val Gln Ala 
65                  70                  75                  80  


Cys Arg Ala Leu Met Ile Ala Ala Ser Val Leu Gly Leu Pro Ala Ile 
                85                  90                  95      


Leu Leu Leu Leu Thr Val Leu Pro Cys Ile Arg Met Gly Gln Glu Pro 
            100                 105                 110         


Gly Val Ala Lys Tyr Arg Arg Ala Gln Leu Ala Gly Val Leu Leu Ile 
        115                 120                 125             


Leu Leu Ala Leu Cys Ala Leu Val Ala Thr Ile Trp Phe Pro Val Cys 
    130                 135                 140                 


Ala His Arg Glu Thr Thr Ile Val Ser Phe Gly Tyr Ser Leu Tyr Ala 
145                 150                 155                 160 


Gly Trp Ile Gly Ala Val Leu Cys Leu Val Gly Gly Cys Val Ile Leu 
                165                 170                 175     


Cys Cys Ala Gly Asp Ala Gln Ala Phe Gly Glu Asn Arg Phe Tyr Tyr 
            180                 185                 190         


Thr Ala Gly Ser Ser Ser Pro Thr His Ala Lys Ser Ala His Val 
        195                 200                 205         


<210>  2243
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN14__Homo_sapiens__NP_036262

<400>  2243

Met Ala Ser Thr Ala Val Gln Leu Leu Gly Phe Leu Leu Ser Phe Leu 
1               5                   10                  15      


Gly Met Val Gly Thr Leu Ile Thr Thr Ile Leu Pro His Trp Arg Arg 
            20                  25                  30          


Thr Ala His Val Gly Thr Asn Ile Leu Thr Ala Val Ser Tyr Leu Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Val Trp His Ser Thr Gly Ile Tyr Gln Cys 
    50                  55                  60                  


Gln Ile Tyr Arg Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Ile Ser Cys Leu Leu Ser Gly Ile Ala Cys Ala 
                85                  90                  95      


Cys Ala Val Ile Gly Met Lys Cys Thr Arg Cys Ala Lys Gly Thr Pro 
            100                 105                 110         


Ala Lys Thr Thr Phe Ala Ile Leu Gly Gly Thr Leu Phe Ile Leu Ala 
        115                 120                 125             


Gly Leu Leu Cys Met Val Ala Val Ser Trp Thr Thr Asn Asp Val Val 
    130                 135                 140                 


Gln Asn Phe Tyr Asn Pro Leu Leu Pro Ser Gly Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Gln Ala Leu Tyr Leu Gly Phe Ile Ser Ser Ser Leu Ser Leu Ile 
                165                 170                 175     


Gly Gly Thr Leu Leu Cys Leu Ser Cys Gln Asp Glu Ala Pro Tyr Arg 
            180                 185                 190         


Pro Tyr Gln Ala Pro Pro Arg Ala Thr Thr Thr Thr Ala Asn Thr Ala 
        195                 200                 205             


Pro Ala Tyr Gln Pro Pro Ala Ala Tyr Lys Asp Asn Arg Ala Pro Ser 
    210                 215                 220                 


Val Thr Ser Ala Thr His Ser Gly Tyr Arg Leu Asn Asp Tyr Val 
225                 230                 235                 


<210>  2244
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN15__Homo_sapiens__NP_001172009

<400>  2244

Met Ser Met Ala Val Glu Thr Phe Gly Phe Phe Met Ala Thr Val Gly 
1               5                   10                  15      


Leu Leu Met Leu Gly Val Thr Leu Pro Asn Ser Tyr Trp Arg Val Ser 
            20                  25                  30          


Thr Val His Gly Asn Val Ile Thr Thr Asn Thr Ile Phe Glu Asn Leu 
        35                  40                  45              


Trp Phe Ser Cys Ala Thr Asp Ser Leu Gly Val Tyr Asn Cys Trp Glu 
    50                  55                  60                  


Phe Pro Ser Met Leu Ala Leu Ser Gly Tyr Ile Gln Ala Cys Arg Ala 
65                  70                  75                  80  


Leu Met Ile Thr Ala Ile Leu Leu Gly Phe Leu Gly Leu Leu Leu Gly 
                85                  90                  95      


Ile Ala Gly Leu Arg Cys Thr Asn Ile Gly Gly Leu Glu Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Ala Ala Thr Ala Gly Ala Leu His Ile Leu Ala Gly 
        115                 120                 125             


Ile Cys Gly Met Val Ala Ile Ser Trp Tyr Ala Phe Asn Ile Thr Arg 
    130                 135                 140                 


Asp Phe Phe Asp Pro Leu Tyr Pro Gly Thr Lys Tyr Glu Leu Gly Pro 
145                 150                 155                 160 


Ala Leu Tyr Leu Gly Trp Ser Ala Ser Leu Ile Ser Ile Leu Gly Gly 
                165                 170                 175     


Leu Cys Leu Cys Ser Ala Cys Cys Cys Gly Ser Asp Glu Asp Pro Ala 
            180                 185                 190         


Ala Ser Ala Arg Arg Pro Tyr Gln Ala Pro Val Ser Val Met Pro Val 
        195                 200                 205             


Ala Thr Ser Asp Gln Glu Gly Asp Ser Ser Phe Gly Lys Tyr Gly Arg 
    210                 215                 220                 


Asn Ala Tyr Val 
225             


<210>  2245
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN16__Homo_sapiens__NP_006571

<400>  2245

Met Thr Ser Arg Thr Pro Leu Leu Val Thr Ala Cys Leu Tyr Tyr Ser 
1               5                   10                  15      


Tyr Cys Asn Ser Arg His Leu Gln Gln Gly Val Arg Lys Ser Lys Arg 
            20                  25                  30          


Pro Val Phe Ser His Cys Gln Val Pro Glu Thr Gln Lys Thr Asp Thr 
        35                  40                  45              


Arg His Leu Ser Gly Ala Arg Ala Gly Val Cys Pro Cys Cys His Pro 
    50                  55                  60                  


Asp Gly Leu Leu Ala Thr Met Arg Asp Leu Leu Gln Tyr Ile Ala Cys 
65                  70                  75                  80  


Phe Phe Ala Phe Phe Ser Ala Gly Phe Leu Ile Val Ala Thr Trp Thr 
                85                  90                  95      


Asp Cys Trp Met Val Asn Ala Asp Asp Ser Leu Glu Val Ser Thr Lys 
            100                 105                 110         


Cys Arg Gly Leu Trp Trp Glu Cys Val Thr Asn Ala Phe Asp Gly Ile 
        115                 120                 125             


Arg Thr Cys Asp Glu Tyr Asp Ser Ile Leu Ala Glu His Pro Leu Lys 
    130                 135                 140                 


Leu Val Val Thr Arg Ala Leu Met Ile Thr Ala Asp Ile Leu Ala Gly 
145                 150                 155                 160 


Phe Gly Phe Leu Thr Leu Leu Leu Gly Leu Asp Cys Val Lys Phe Leu 
                165                 170                 175     


Pro Asp Glu Pro Tyr Ile Lys Val Arg Ile Cys Phe Val Ala Gly Ala 
            180                 185                 190         


Thr Leu Leu Ile Ala Gly Thr Pro Gly Ile Ile Gly Ser Val Trp Tyr 
        195                 200                 205             


Ala Val Asp Val Tyr Val Glu Arg Ser Thr Leu Val Leu His Asn Ile 
    210                 215                 220                 


Phe Leu Gly Ile Gln Tyr Lys Phe Gly Trp Ser Cys Trp Leu Gly Met 
225                 230                 235                 240 


Ala Gly Ser Leu Gly Cys Phe Leu Ala Gly Ala Val Leu Thr Cys Cys 
                245                 250                 255     


Leu Tyr Leu Phe Lys Asp Val Gly Pro Glu Arg Asn Tyr Pro Tyr Ser 
            260                 265                 270         


Leu Arg Lys Ala Tyr Ser Ala Ala Gly Val Ser Met Ala Lys Ser Tyr 
        275                 280                 285             


Ser Ala Pro Arg Thr Glu Thr Ala Lys Met Tyr Ala Val Asp Thr Arg 
    290                 295                 300                 


Val 
305 


<210>  2246
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN18__Homo_sapiens__NP_001002026

<400>  2246

Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  2247
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN1__Homo_sapiens__NP_066924

<400>  2247

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  2248
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN23__Homo_sapiens__NP_919260

<400>  2248

Met Arg Thr Pro Val Val Met Thr Leu Gly Met Val Leu Ala Pro Cys 
1               5                   10                  15      


Gly Leu Leu Leu Asn Leu Thr Gly Thr Leu Ala Pro Gly Trp Arg Leu 
            20                  25                  30          


Val Lys Gly Phe Leu Asn Gln Pro Val Asp Val Glu Leu Tyr Gln Gly 
        35                  40                  45              


Leu Trp Asp Met Cys Arg Glu Gln Ser Ser Arg Glu Arg Glu Cys Gly 
    50                  55                  60                  


Gln Thr Asp Gln Trp Gly Tyr Phe Glu Ala Gln Pro Val Leu Val Ala 
65                  70                  75                  80  


Arg Ala Leu Met Val Thr Ser Leu Ala Ala Thr Val Leu Gly Leu Leu 
                85                  90                  95      


Leu Ala Ser Leu Gly Val Arg Cys Trp Gln Asp Glu Pro Asn Phe Val 
            100                 105                 110         


Leu Ala Gly Leu Ser Gly Val Val Leu Phe Val Ala Gly Leu Leu Gly 
        115                 120                 125             


Leu Ile Pro Val Ser Trp Tyr Asn His Phe Leu Gly Asp Arg Asp Val 
    130                 135                 140                 


Leu Pro Ala Pro Ala Ser Pro Val Thr Val Gln Val Ser Tyr Ser Leu 
145                 150                 155                 160 


Val Leu Gly Tyr Leu Gly Ser Cys Leu Leu Leu Leu Gly Gly Phe Ser 
                165                 170                 175     


Leu Ala Leu Ser Phe Ala Pro Trp Cys Asp Glu Arg Cys Arg Arg Arg 
            180                 185                 190         


Arg Lys Gly Pro Ser Ala Gly Pro Arg Arg Ser Ser Val Ser Thr Ile 
        195                 200                 205             


Gln Val Glu Trp Pro Glu Pro Asp Leu Ala Pro Ala Ile Lys Tyr Tyr 
    210                 215                 220                 


Ser Asp Gly Gln His Arg Pro Pro Pro Ala Gln His Arg Lys Pro Lys 
225                 230                 235                 240 


Pro Lys Pro Lys Val Gly Phe Pro Met Pro Arg Pro Arg Pro Lys Ala 
                245                 250                 255     


Tyr Thr Asn Ser Val Asp Val Leu Asp Gly Glu Gly Trp Glu Ser Gln 
            260                 265                 270         


Asp Ala Pro Ser Cys Ser Thr His Pro Cys Asp Ser Ser Leu Pro Cys 
        275                 280                 285             


Asp Ser Asp Leu 
    290         


<210>  2249
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN2__Homo_sapiens__NP_001164566

<400>  2249

Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210>  2250
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN5__Homo_sapiens__NP_001124333

<400>  2250

Met Thr Arg Ala Arg Ile Gly Cys Phe Gly Pro Gly Gly Arg Ala Arg 
1               5                   10                  15      


Gly Thr Glu Ser Ala Pro Glu Pro Ser Lys Arg Val Pro Pro Gly Arg 
            20                  25                  30          


Ser Trp Gln Thr Gln Glu Val Arg Gln Thr Arg Gly Ala Asn Gly Leu 
        35                  40                  45              


Gly Pro Arg Ala Gly Ser Ala Gly Ala Lys Ala Pro Gly Pro Ala Gln 
    50                  55                  60                  


Gly Ala Ala Gln His Gly Leu Gly Gly Ser Ala Gly Leu Arg Val Arg 
65                  70                  75                  80  


Val Ser Pro Leu Ala Met Gly Ser Ala Ala Leu Glu Ile Leu Gly Leu 
                85                  90                  95      


Val Leu Cys Leu Val Gly Trp Gly Gly Leu Ile Leu Ala Cys Gly Leu 
            100                 105                 110         


Pro Met Trp Gln Val Thr Ala Phe Leu Asp His Asn Ile Val Thr Ala 
        115                 120                 125             


Gln Thr Thr Trp Lys Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr 
    130                 135                 140                 


Gly His Met Gln Cys Lys Val Tyr Asp Ser Val Leu Ala Leu Ser Thr 
145                 150                 155                 160 


Glu Val Gln Ala Ala Arg Ala Leu Thr Val Ser Ala Val Leu Leu Ala 
                165                 170                 175     


Phe Val Ala Leu Phe Val Thr Leu Ala Gly Ala Gln Cys Thr Thr Cys 
            180                 185                 190         


Val Ala Pro Gly Pro Ala Lys Ala Arg Val Ala Leu Thr Gly Gly Val 
        195                 200                 205             


Leu Tyr Leu Phe Cys Gly Leu Leu Ala Leu Val Pro Leu Cys Trp Phe 
    210                 215                 220                 


Ala Asn Ile Val Val Arg Glu Phe Tyr Asp Pro Ser Val Pro Val Ser 
225                 230                 235                 240 


Gln Lys Tyr Glu Leu Gly Ala Ala Leu Tyr Ile Gly Trp Ala Ala Thr 
                245                 250                 255     


Ala Leu Leu Met Val Gly Gly Cys Leu Leu Cys Cys Gly Ala Trp Val 
            260                 265                 270         


Cys Thr Gly Arg Pro Asp Leu Ser Phe Pro Val Lys Tyr Ser Ala Pro 
        275                 280                 285             


Arg Arg Pro Thr Ala Thr Gly Asp Tyr Asp Lys Lys Asn Tyr Val 
    290                 295                 300             


<210>  2251
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN6__Homo_sapiens__NP_067018

<400>  2251

Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 
1               5                   10                  15      


Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 
                85                  90                  95      


Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 
            100                 105                 110         


Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 
        115                 120                 125             


Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 
            180                 185                 190         


Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 
        195                 200                 205             


Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
    210                 215                 220 


<210>  2252
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN7__Homo_sapiens__NP_001171952

<400>  2252

Met Ala Asn Ser Gly Leu Gln Leu Leu Gly Phe Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Trp Val Gly Leu Val Ala Cys Thr Ala Ile Pro Gln Trp Gln Met 
            20                  25                  30          


Ser Ser Tyr Ala Gly Asp Asn Ile Ile Thr Ala Gln Ala Met Tyr Lys 
        35                  40                  45              


Gly Leu Trp Met Asp Cys Val Thr Gln Ser Thr Gly Met Met Ser Cys 
    50                  55                  60                  


Lys Met Tyr Asp Ser Val Leu Ala Leu Ser Ala Ala Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Ser Leu Val Leu Gly Phe Leu Ala Met Phe 
                85                  90                  95      


Val Ala Thr Met Gly Met Lys Cys Thr Arg Cys Gly Gly Asp Asp Lys 
            100                 105                 110         


Val Lys Lys Ala Arg Ile Ala Met Gly Gly Gly Ile Ile Phe Ile Val 
        115                 120                 125             


Ala Gly Met Ser Leu Ala Leu Pro Ser Leu Leu Ala Gly Gln Gly Leu 
    130                 135                 140                 


Pro 
145 


<210>  2253
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN8__Homo_sapiens__NP_955360

<400>  2253

Met Ala Thr His Ala Leu Glu Ile Ala Gly Leu Phe Leu Gly Gly Val 
1               5                   10                  15      


Gly Met Val Gly Thr Val Ala Val Thr Val Met Pro Gln Trp Arg Val 
            20                  25                  30          


Ser Ala Phe Ile Glu Asn Asn Ile Val Val Phe Glu Asn Phe Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Asn Cys Val Arg Gln Ala Asn Ile Arg Met Gln Cys 
    50                  55                  60                  


Lys Ile Tyr Asp Ser Leu Leu Ala Leu Ser Pro Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Gly Leu Met Cys Ala Ala Ser Val Met Ser Phe Leu Ala Phe Met 
                85                  90                  95      


Met Ala Ile Leu Gly Met Lys Cys Thr Arg Cys Thr Gly Asp Asn Glu 
            100                 105                 110         


Lys Val Lys Ala His Ile Leu Leu Thr Ala Gly Ile Ile Phe Ile Ile 
        115                 120                 125             


Thr Gly Met Val Val Leu Ile Pro Val Ser Trp Val Ala Asn Ala Ile 
    130                 135                 140                 


Ile Arg Asp Phe Tyr Asn Ser Ile Val Asn Val Ala Gln Lys Arg Glu 
145                 150                 155                 160 


Leu Gly Glu Ala Leu Tyr Leu Gly Trp Thr Thr Ala Leu Val Leu Ile 
                165                 170                 175     


Val Gly Gly Ala Leu Phe Cys Cys Val Phe Cys Cys Asn Glu Lys Ser 
            180                 185                 190         


Ser Ser Tyr Arg Tyr Ser Ile Pro Ser His Arg Thr Thr Gln Lys Ser 
        195                 200                 205             


Tyr His Thr Gly Lys Lys Ser Pro Ser Val Tyr Ser Arg Ser Gln Tyr 
    210                 215                 220                 


Val 
225 


<210>  2254
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLDN9__Homo_sapiens__NP_066192

<400>  2254

Met Ala Ser Thr Gly Leu Glu Leu Leu Gly Met Thr Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Gly Thr Leu Val Ser Cys Ala Leu Pro Leu Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Leu Ala Leu Leu Gly Leu Leu 
                85                  90                  95      


Val Ala Ile Thr Gly Ala Gln Cys Thr Thr Cys Val Glu Asp Glu Gly 
            100                 105                 110         


Ala Lys Ala Arg Ile Val Leu Thr Ala Gly Val Ile Leu Leu Leu Ala 
        115                 120                 125             


Gly Ile Leu Val Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Leu Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ala Ala Leu Leu Met Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Pro Pro Gln Val Glu Arg 
            180                 185                 190         


Pro Arg Gly Pro Arg Leu Gly Tyr Ser Ile Pro Ser Arg Ser Gly Ala 
        195                 200                 205             


Ser Gly Leu Asp Lys Arg Asp Tyr Val 
    210                 215         


<210>  2255
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC10A__Homo_sapiens__NP_006335

<400>  2255

Met Thr Arg Thr Tyr Glu Asn Phe Gln Tyr Leu Glu Asn Lys Val Lys 
1               5                   10                  15      


Val Gln Gly Phe Lys Asn Gly Pro Leu Pro Leu Gln Ser Leu Leu Gln 
            20                  25                  30          


Arg Leu Cys Ser Gly Pro Cys His Leu Leu Leu Ser Leu Gly Leu Gly 
        35                  40                  45              


Leu Leu Leu Leu Val Ile Ile Cys Val Val Gly Phe Gln Asn Ser Lys 
    50                  55                  60                  


Phe Gln Arg Asp Leu Val Thr Leu Arg Thr Asp Phe Ser Asn Phe Thr 
65                  70                  75                  80  


Ser Asn Thr Val Ala Glu Ile Gln Ala Leu Thr Ser Gln Gly Ser Ser 
                85                  90                  95      


Leu Glu Glu Thr Ile Ala Ser Leu Lys Ala Glu Val Glu Gly Phe Lys 
            100                 105                 110         


Gln Glu Arg Gln Ala Val His Ser Glu Met Leu Leu Arg Val Gln Gln 
        115                 120                 125             


Leu Val Gln Asp Leu Lys Lys Leu Thr Cys Gln Val Ala Thr Leu Asn 
    130                 135                 140                 


Asn Asn Gly Glu Glu Ala Ser Thr Glu Gly Thr Cys Cys Pro Val Asn 
145                 150                 155                 160 


Trp Val Glu His Gln Asp Ser Cys Tyr Trp Phe Ser His Ser Gly Met 
                165                 170                 175     


Ser Trp Ala Glu Ala Glu Lys Tyr Cys Gln Leu Lys Asn Ala His Leu 
            180                 185                 190         


Val Val Ile Asn Ser Arg Glu Glu Gln Asn Phe Val Gln Lys Tyr Leu 
        195                 200                 205             


Gly Ser Ala Tyr Thr Trp Met Gly Leu Ser Asp Pro Glu Gly Ala Trp 
    210                 215                 220                 


Lys Trp Val Asp Gly Thr Asp Tyr Ala Thr Gly Phe Gln Asn Trp Lys 
225                 230                 235                 240 


Pro Gly Gln Pro Asp Asp Trp Gln Gly His Gly Leu Gly Gly Gly Glu 
                245                 250                 255     


Asp Cys Ala His Phe His Pro Asp Gly Arg Trp Asn Asp Asp Val Cys 
            260                 265                 270         


Gln Arg Pro Tyr His Trp Val Cys Glu Ala Gly Leu Gly Gln Thr Ser 
        275                 280                 285             


Gln Glu Ser His 
    290         


<210>  2256
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC11A__Homo_sapiens__NP_002966

<400>  2256

Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu 
1               5                   10                  15      


Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 
            20                  25                  30          


Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 
        35                  40                  45              


Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 
    50                  55                  60                  


Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu 
65                  70                  75                  80  


Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 
                85                  90                  95      


Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 
            100                 105                 110         


Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 
        115                 120                 125             


Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 
    130                 135                 140                 


Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly 
                165                 170                 175     


Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg 
            180                 185                 190         


Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly 
        195                 200                 205             


Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr 
    210                 215                 220                 


Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu 
225                 230                 235                 240 


Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly 
                245                 250                 255     


Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu 
            260                 265                 270         


Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro 
        275                 280                 285             


Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly 
    290                 295                 300                 


Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu 
305                 310                 315                 320 


Phe Pro Phe 
            


<210>  2257
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC12A__Homo_sapiens__NP_001193939

<400>  2257

Met Trp Ile Asp Phe Phe Thr Tyr Ser Ser Met Ser Glu Glu Val Thr 
1               5                   10                  15      


Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser Glu Met Glu Lys Ile Pro 
            20                  25                  30          


Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro Pro Ala Pro Ser His Val 
        35                  40                  45              


Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu Leu Cys Leu Leu Leu Leu 
    50                  55                  60                  


Ile Gly Leu Gly Val Leu Ala Ser Met Phe His Val Thr Leu Lys Ile 
65                  70                  75                  80  


Glu Met Lys Lys Met Asn Lys Leu Gln Asn Ile Ser Glu Glu Leu Gln 
                85                  90                  95      


Arg Asn Ile Ser Leu Gln Leu Met Ser Asn Met Asn Ile Ser Asn Lys 
            100                 105                 110         


Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr Ile Ala Thr Lys Leu Cys 
        115                 120                 125             


Arg Glu Leu Tyr Ser Lys Glu Gln Glu His Lys Cys Lys Pro Cys Pro 
    130                 135                 140                 


Arg Arg Trp Ile Trp His Lys Asp Ser Cys Tyr Phe Leu Ser Asp Asp 
145                 150                 155                 160 


Val Gln Thr Trp Gln Glu Ser Lys Met Ala Cys Ala Ala Gln Asn Ala 
                165                 170                 175     


Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala Leu Glu Phe Ile Lys Ser 
            180                 185                 190         


Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly Leu Ser Pro Glu Glu Asp 
        195                 200                 205             


Ser Thr Arg Gly Met Arg Val Asp Asn Ile Ile Asn Ser Ser Ala Trp 
    210                 215                 220                 


Val Ile Arg Asn Ala Pro Asp Leu Asn Asn Met Tyr Cys Gly Tyr Ile 
225                 230                 235                 240 


Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys Thr Tyr Lys Lys Arg Met 
                245                 250                 255     


Ile Cys Glu Lys Met Ala Asn Pro Val Gln Leu Gly Ser Thr Tyr Phe 
            260                 265                 270         


Arg Glu Ala 
        275 


<210>  2258
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC14A__Homo_sapiens__NP_778230

<400>  2258

Met Arg Pro Ala Phe Ala Leu Cys Leu Leu Trp Gln Ala Leu Trp Pro 
1               5                   10                  15      


Gly Pro Gly Gly Gly Glu His Pro Thr Ala Asp Arg Ala Gly Cys Ser 
            20                  25                  30          


Ala Ser Gly Ala Cys Tyr Ser Leu His His Ala Thr Met Lys Arg Gln 
        35                  40                  45              


Ala Ala Glu Glu Ala Cys Ile Leu Arg Gly Gly Ala Leu Ser Thr Val 
    50                  55                  60                  


Arg Ala Gly Ala Glu Leu Arg Ala Val Leu Ala Leu Leu Arg Ala Gly 
65                  70                  75                  80  


Pro Gly Pro Gly Gly Gly Ser Lys Asp Leu Leu Phe Trp Val Ala Leu 
                85                  90                  95      


Glu Arg Arg Arg Ser His Cys Thr Leu Glu Asn Glu Pro Leu Arg Gly 
            100                 105                 110         


Phe Ser Trp Leu Ser Ser Asp Pro Gly Gly Leu Glu Ser Asp Thr Leu 
        115                 120                 125             


Gln Trp Val Glu Glu Pro Gln Arg Ser Cys Thr Ala Arg Arg Cys Ala 
    130                 135                 140                 


Val Leu Gln Ala Thr Gly Gly Val Glu Pro Ala Gly Trp Lys Glu Met 
145                 150                 155                 160 


Arg Cys His Leu Arg Ala Asn Gly Tyr Leu Cys Lys Tyr Gln Phe Glu 
                165                 170                 175     


Val Leu Cys Pro Ala Pro Arg Pro Gly Ala Ala Ser Asn Leu Ser Tyr 
            180                 185                 190         


Arg Ala Pro Phe Gln Leu His Ser Ala Ala Leu Asp Phe Ser Pro Pro 
        195                 200                 205             


Gly Thr Glu Val Ser Ala Leu Cys Arg Gly Gln Leu Pro Ile Ser Val 
    210                 215                 220                 


Thr Cys Ile Ala Asp Glu Ile Gly Ala Arg Trp Asp Lys Leu Ser Gly 
225                 230                 235                 240 


Asp Val Leu Cys Pro Cys Pro Gly Arg Tyr Leu Arg Ala Gly Lys Cys 
                245                 250                 255     


Ala Glu Leu Pro Asn Cys Leu Asp Asp Leu Gly Gly Phe Ala Cys Glu 
            260                 265                 270         


Cys Ala Thr Gly Phe Glu Leu Gly Lys Asp Gly Arg Ser Cys Val Thr 
        275                 280                 285             


Ser Gly Glu Gly Gln Pro Thr Leu Gly Gly Thr Gly Val Pro Thr Arg 
    290                 295                 300                 


Arg Pro Pro Ala Thr Ala Thr Ser Pro Val Pro Gln Arg Thr Trp Pro 
305                 310                 315                 320 


Ile Arg Val Asp Glu Lys Leu Gly Glu Thr Pro Leu Val Pro Glu Gln 
                325                 330                 335     


Asp Asn Ser Val Thr Ser Ile Pro Glu Ile Pro Arg Trp Gly Ser Gln 
            340                 345                 350         


Ser Thr Met Ser Thr Leu Gln Met Ser Leu Gln Ala Glu Ser Lys Ala 
        355                 360                 365             


Thr Ile Thr Pro Ser Gly Ser Val Ile Ser Lys Phe Asn Ser Thr Thr 
    370                 375                 380                 


Ser Ser Ala Thr Pro Gln Ala Phe Asp Ser Ser Ser Ala Val Val Phe 
385                 390                 395                 400 


Ile Phe Val Ser Thr Ala Val Val Val Leu Val Ile Leu Thr Met Thr 
                405                 410                 415     


Val Leu Gly Leu Val Lys Leu Cys Phe His Glu Ser Pro Ser Ser Gln 
            420                 425                 430         


Pro Arg Lys Glu Ser Met Gly Pro Pro Gly Leu Glu Ser Asp Pro Glu 
        435                 440                 445             


Pro Ala Ala Leu Gly Ser Ser Ser Ala His Cys Thr Asn Asn Gly Val 
    450                 455                 460                 


Lys Val Gly Asp Cys Asp Leu Arg Asp Arg Ala Glu Gly Ala Leu Leu 
465                 470                 475                 480 


Ala Glu Ser Pro Leu Gly Ser Ser Asp Ala 
                485                 490 


<210>  2259
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC16A__Homo_sapiens__NP_001230332

<400>  2259

Met Phe Gly Arg Ser Arg Ser Trp Val Gly Gly Gly His Gly Lys Thr 
1               5                   10                  15      


Ser Arg Asn Ile His Ser Leu Asp His Leu Lys Tyr Leu Tyr His Val 
            20                  25                  30          


Leu Thr Lys Asn Thr Thr Val Thr Glu Gln Asn Arg Asn Leu Leu Val 
        35                  40                  45              


Glu Thr Ile Arg Ser Ile Thr Glu Ile Leu Ile Trp Gly Asp Gln Asn 
    50                  55                  60                  


Asp Ser Ser Val Phe Asp Phe Phe Leu Glu Lys Asn Met Phe Val Phe 
65                  70                  75                  80  


Phe Leu Asn Ile Leu Arg Gln Lys Ser Gly Arg Tyr Val Cys Val Gln 
                85                  90                  95      


Leu Leu Gln Thr Leu Asn Ile Leu Phe Glu Asn Ile Ser His Glu Thr 
            100                 105                 110         


Ser Leu Tyr Tyr Leu Leu Ser Asn Asn Tyr Val Asn Ser Ile Ile Val 
        115                 120                 125             


His Lys Phe Asp Phe Ser Asp Glu Glu Ile Met Ala Tyr Tyr Ile Ser 
    130                 135                 140                 


Phe Leu Lys Thr Leu Ser Leu Lys Leu Asn Asn His Thr Val His Phe 
145                 150                 155                 160 


Phe Tyr Asn Glu His Thr Asn Asp Phe Ala Leu Tyr Thr Glu Ala Ile 
                165                 170                 175     


Lys Phe Phe Asn His Pro Glu Ser Met Val Arg Ile Ala Val Arg Thr 
            180                 185                 190         


Ile Thr Leu Asn Val Tyr Lys Val Asp Asn Gln Ala Met Leu His Tyr 
        195                 200                 205             


Ile Arg Asp Lys Thr Ala Val Pro Tyr Phe Ser Asn Leu Val Trp Phe 
    210                 215                 220                 


Ile Gly Ser His Val Ile Glu Leu Asp Asp Cys Val Gln Thr Asp Glu 
225                 230                 235                 240 


Glu His Arg Asn Arg Gly Lys Leu Ser Asp Leu Val Ala Glu His Leu 
                245                 250                 255     


Asp His Leu His Tyr Leu Asn Asp Ile Leu Ile Ile Asn Cys Glu Phe 
            260                 265                 270         


Leu Asn Asp Val Leu Thr Asp His Leu Leu Asn Arg Leu Phe Leu Pro 
        275                 280                 285             


Leu Tyr Val Tyr Ser Leu Glu Asn Gln Asp Lys Gly Gly Glu Arg Pro 
    290                 295                 300                 


Lys Ile Ser Leu Pro Val Ser Leu Tyr Leu Leu Ser Gln Val Phe Leu 
305                 310                 315                 320 


Ile Ile His His Ala Pro Leu Val Asn Ser Leu Ala Glu Val Ile Leu 
                325                 330                 335     


Asn Gly Asp Leu Ser Glu Met Tyr Ala Lys Thr Glu Gln Asp Ile Gln 
            340                 345                 350         


Arg Ser Ser Ala Lys Pro Ser Ile Arg Cys Phe Ile Lys Pro Thr Glu 
        355                 360                 365             


Thr Leu Glu Arg Ser Leu Glu Met Asn Lys His Lys Gly Lys Arg Arg 
    370                 375                 380                 


Val Gln Lys Arg Pro Asn Tyr Lys Asn Val Gly Glu Glu Glu Asp Glu 
385                 390                 395                 400 


Glu Lys Gly Pro Thr Glu Asp Ala Gln Glu Asp Ala Glu Lys Ala Lys 
                405                 410                 415     


Glu Ile Glu Met Val Ile Met Glu Arg Ser Lys Leu Ser Glu Leu Ala 
            420                 425                 430         


Ala Ser Thr Ser Val Gln Glu Gln Asn Thr Thr Asp Glu Glu Lys Ser 
        435                 440                 445             


Ala Ala Ala Thr Cys Ser Glu Ser Thr Gln Trp Ser Arg Pro Phe Leu 
    450                 455                 460                 


Asp Met Val Tyr His Ala Leu Asp Ser Pro Asp Asp Asp Tyr His Ala 
465                 470                 475                 480 


Leu Phe Val Leu Cys Leu Leu Tyr Ala Met Ser His Asn Lys Gly Met 
                485                 490                 495     


Asp Pro Glu Lys Leu Glu Arg Ile Gln Leu Pro Val Pro Asn Ala Ala 
            500                 505                 510         


Glu Lys Thr Thr Tyr Asn His Pro Leu Ala Glu Arg Leu Ile Arg Ile 
        515                 520                 525             


Met Asn Asn Ala Ala Gln Pro Asp Gly Lys Ile Arg Leu Ala Thr Leu 
    530                 535                 540                 


Glu Leu Ser Cys Leu Leu Leu Lys Gln Gln Val Leu Met Ser Ala Gly 
545                 550                 555                 560 


Cys Ile Met Lys Asp Val His Leu Ala Cys Leu Glu Gly Ala Arg Glu 
                565                 570                 575     


Glu Ser Val His Leu Val Arg His Phe Tyr Lys Gly Glu Asp Ile Phe 
            580                 585                 590         


Leu Asp Met Phe Glu Asp Glu Tyr Arg Ser Met Thr Met Lys Pro Met 
        595                 600                 605             


Asn Val Glu Tyr Leu Met Met Asp Ala Ser Ile Leu Leu Pro Pro Thr 
    610                 615                 620                 


Gly Thr Pro Leu Thr Gly Ile Asp Phe Val Lys Arg Leu Pro Cys Gly 
625                 630                 635                 640 


Asp Val Glu Lys Thr Arg Arg Ala Ile Arg Val Phe Phe Met Leu Arg 
                645                 650                 655     


Ser Leu Ser Leu Gln Leu Arg Gly Glu Pro Glu Thr Gln Leu Pro Leu 
            660                 665                 670         


Thr Arg Glu Glu Asp Leu Ile Lys Thr Asp Asp Val Leu Asp Leu Asn 
        675                 680                 685             


Asn Ser Asp Leu Ile Ala Cys Thr Val Ile Thr Lys Asp Gly Gly Met 
    690                 695                 700                 


Val Gln Arg Phe Leu Ala Val Asp Ile Tyr Gln Met Ser Leu Val Glu 
705                 710                 715                 720 


Pro Asp Val Ser Arg Leu Gly Trp Gly Val Val Lys Phe Ala Gly Leu 
                725                 730                 735     


Leu Gln Asp Met Gln Val Thr Gly Val Glu Asp Asp Ser Arg Ala Leu 
            740                 745                 750         


Asn Ile Thr Ile His Lys Pro Ala Ser Ser Pro His Ser Lys Pro Phe 
        755                 760                 765             


Pro Ile Leu Gln Ala Thr Phe Ile Phe Ser Asp His Ile Arg Cys Ile 
    770                 775                 780                 


Ile Ala Lys Gln Arg Leu Ala Lys Gly Arg Ile Gln Ala Arg Arg Met 
785                 790                 795                 800 


Lys Met Gln Arg Ile Ala Ala Leu Leu Asp Leu Pro Ile Gln Pro Thr 
                805                 810                 815     


Thr Glu Val Leu Gly Phe Gly Leu Gly Ser Ser Thr Ser Thr Gln His 
            820                 825                 830         


Leu Pro Phe Arg Phe Tyr Asp Gln Gly Arg Arg Gly Ser Ser Asp Pro 
        835                 840                 845             


Thr Val Gln Arg Ser Val Phe Ala Ser Val Asp Lys Val Pro Gly Glu 
    850                 855                 860                 


Pro Ala Pro Arg Pro Ala Pro Gln Leu Val His His Gly Gly Arg Ser 
865                 870                 875                 880 


Arg Ser Phe Ser Leu Trp Ser Leu Cys Glu Leu Pro Phe Leu Ser Gln 
                885                 890                 895     


Lys Pro Arg Arg Leu Ala Ala Pro Ala Ser 
            900                 905     


<210>  2260
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC1B__Homo_sapiens__NP_001092901

<400>  2260

Met Gln Asp Glu Asp Gly Tyr Ile Thr Leu Asn Ile Lys Thr Arg Lys 
1               5                   10                  15      


Pro Ala Leu Ile Ser Ala Val Met Gln Arg Asn Tyr Leu Gln Gly Glu 
            20                  25                  30          


Asn Glu Asn Arg Thr Gly Thr Leu Gln Gln Leu Ala Lys Arg Phe Cys 
        35                  40                  45              


Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Thr Phe Lys Gly His 
    50                  55                  60                  


Lys Cys Ser Pro Cys Asp Thr Asn Trp Arg Tyr Tyr Gly Asp Ser Cys 
65                  70                  75                  80  


Tyr Gly Phe Phe Arg His Asn Leu Thr Trp Glu Glu Ser Lys Gln Tyr 
                85                  90                  95      


Cys Thr Asp Met Asn Ala Thr Leu Leu Lys Ile Asp Asn Arg Asn Ile 
            100                 105                 110         


Val Glu Tyr Ile Lys Ala Arg Thr His Leu Ile Arg Trp Val Gly Leu 
        115                 120                 125             


Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser Val 
    130                 135                 140                 


Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn Met 
145                 150                 155                 160 


Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Thr Phe Cys Glu 
                165                 170                 175     


Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Thr Lys Val 
            180                 185                 190         


Asp Gln Leu Pro 
        195     


<210>  2261
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC2A__Homo_sapiens__NP_001124183

<400>  2261

Met Ile Asn Pro Glu Leu Arg Asp Gly Arg Ala Asp Gly Phe Ile His 
1               5                   10                  15      


Arg Ile Val Pro Lys Leu Ile Gln Asn Trp Lys Ile Gly Leu Met Cys 
            20                  25                  30          


Phe Leu Ser Ile Ile Ile Thr Thr Val Cys Ile Ile Met Ile Ala Thr 
        35                  40                  45              


Trp Ser Lys His Ala Lys Pro Val Ala Cys Ser Gly Asp Trp Leu Gly 
    50                  55                  60                  


Val Arg Asp Lys Cys Phe Tyr Phe Ser Asp Asp Thr Arg Asn Trp Thr 
65                  70                  75                  80  


Ala Ser Lys Ile Phe Cys Ser Leu Gln Lys Ala Glu Leu Ala Gln Ile 
                85                  90                  95      


Asp Thr Gln Glu Asp Met Glu Phe Leu Lys Arg Tyr Ala Gly Thr Asp 
            100                 105                 110         


Met His Trp Ile Gly Leu Ser Arg Lys Gln Gly Asp Ser Trp Lys Trp 
        115                 120                 125             


Thr Asn Gly Thr Thr Phe Asn Gly Trp Phe Glu Ile Ile Gly Asn Gly 
    130                 135                 140                 


Ser Phe Ala Phe Leu Ser Ala Asp Gly Val His Ser Ser Arg Gly Phe 
145                 150                 155                 160 


Ile Asp Ile Lys Trp Ile Cys Ser Lys Pro Lys Tyr Phe Leu 
                165                 170                 


<210>  2262
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC2B__Homo_sapiens__NP_005118

<400>  2262

Met Met Thr Lys His Lys Lys Cys Phe Ile Ile Val Gly Val Leu Ile 
1               5                   10                  15      


Thr Thr Asn Ile Ile Thr Leu Ile Val Lys Leu Thr Arg Asp Ser Gln 
            20                  25                  30          


Ser Leu Cys Pro Tyr Asp Trp Ile Gly Phe Gln Asn Lys Cys Tyr Tyr 
        35                  40                  45              


Phe Ser Lys Glu Glu Gly Asp Trp Asn Ser Ser Lys Tyr Asn Cys Ser 
    50                  55                  60                  


Thr Gln His Ala Asp Leu Thr Ile Ile Asp Asn Ile Glu Glu Met Asn 
65                  70                  75                  80  


Phe Leu Arg Arg Tyr Lys Cys Ser Ser Asp His Trp Ile Gly Leu Lys 
                85                  90                  95      


Met Ala Lys Asn Arg Thr Gly Gln Trp Val Asp Gly Ala Thr Phe Thr 
            100                 105                 110         


Lys Ser Phe Gly Met Arg Gly Ser Glu Gly Cys Ala Tyr Leu Ser Asp 
        115                 120                 125             


Asp Gly Ala Ala Thr Ala Arg Cys Tyr Thr Glu Arg Lys Trp Ile Cys 
    130                 135                 140                 


Arg Lys Arg Ile His 
145                 


<210>  2263
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC2D__Homo_sapiens__NP_001004419

<400>  2263

Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Thr Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Thr Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Thr Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Thr Lys Asn Trp 
                85                  90                  95      


Thr Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Thr Glu Trp Thr Arg Gln Leu Val Met Lys Glu Asp 
145                 150                 155                 160 


Gly Ala Asn Leu Tyr Val Ala Lys Val Ser Gln Val Pro Arg Met Asn 
                165                 170                 175     


Pro Arg Pro Val Met Val Ser Tyr Pro Gly Ser Arg Arg Val Cys Leu 
            180                 185                 190         


Phe Glu 
        


<210>  2264
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC2L__Homo_sapiens__NP_001073980

<400>  2264

Met Glu Pro Ala Arg Glu Pro Pro Ser Arg Ala Arg Pro Pro Pro Pro 
1               5                   10                  15      


Leu Ala Ala Arg Pro Ala Pro Ala Pro Ala Ala Pro Arg Pro Arg Ser 
            20                  25                  30          


Pro Ala Glu Ala Glu Ala Arg Gly Pro Glu Gly Leu Leu Arg Arg Ser 
        35                  40                  45              


Gly Ser Gly Tyr Glu Gly Ser Thr Ser Trp Lys Ala Ala Leu Glu Asp 
    50                  55                  60                  


Thr Thr Thr Arg Leu Leu Leu Gly Ala Ile Ala Val Leu Leu Phe Ala 
65                  70                  75                  80  


Ile Leu Val Val Met Ser Ile Leu Ala Ser Lys Gly Cys Ile Lys Cys 
                85                  90                  95      


Glu Ala Pro Cys Pro Glu Asp Trp Leu Leu Tyr Gly Arg Lys Cys Tyr 
            100                 105                 110         


Phe Phe Ser Glu Glu Pro Arg Asp Trp Asn Thr Gly Arg Gln Tyr Cys 
        115                 120                 125             


His Thr His Glu Ala Val Leu Ala Val Ile Gln Ser Gln Lys Glu Leu 
    130                 135                 140                 


Glu Phe Met Phe Lys Phe Thr Arg Arg Glu Pro Trp Ile Gly Leu Arg 
145                 150                 155                 160 


Arg Val Gly Asp Glu Phe His Trp Val Asn Gly Asp Pro Phe Asp Pro 
                165                 170                 175     


Asp Thr Phe Thr Ile Ala Gly Pro Gly Glu Cys Val Phe Val Glu Pro 
            180                 185                 190         


Thr Arg Leu Val Ser Thr Glu Cys Leu Met Thr Arg Pro Trp Val Cys 
        195                 200                 205             


Ser Lys Met Ala Tyr Thr 
    210                 


<210>  2265
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC3B__Homo_sapiens__NP_003269

<400>  2265

Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu 
1               5                   10                  15      


Thr Gln Val Thr Thr Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val 
            20                  25                  30          


Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys 
        35                  40                  45              


Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln 
    50                  55                  60                  


Gln Ala Leu Gln Thr Val Cys Leu Lys Gly Thr Lys Val His Met Lys 
65                  70                  75                  80  


Cys Phe Leu Ala Phe Thr Gln Thr Lys Thr Phe His Glu Ala Ser Glu 
                85                  90                  95      


Asp Cys Ile Ser Arg Gly Gly Thr Leu Gly Thr Pro Gln Thr Gly Ser 
            100                 105                 110         


Glu Asn Asp Ala Leu Tyr Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu 
        115                 120                 125             


Ala Glu Ile Trp Leu Gly Leu Asn Asp Met Ala Ala Glu Gly Thr Trp 
    130                 135                 140                 


Val Asp Met Thr Gly Ala Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu 
145                 150                 155                 160 


Ile Thr Ala Gln Pro Asp Gly Gly Lys Thr Glu Asn Cys Ala Val Leu 
                165                 170                 175     


Ser Gly Ala Ala Asn Gly Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln 
            180                 185                 190         


Leu Pro Tyr Ile Cys Gln Phe Gly Ile Val 
        195                 200         


<210>  2266
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC4A__Homo_sapiens__NP_057268

<400>  2266

Met Thr Ser Glu Ile Thr Tyr Ala Glu Val Arg Phe Lys Asn Glu Phe 
1               5                   10                  15      


Lys Ser Ser Gly Ile Asn Thr Ala Ser Ser Ala Ala Ser Lys Glu Arg 
            20                  25                  30          


Thr Ala Pro His Lys Ser Asn Thr Gly Phe Pro Lys Leu Leu Cys Ala 
        35                  40                  45              


Ser Leu Leu Ile Phe Phe Leu Leu Leu Ala Ile Ser Phe Phe Ile Ala 
    50                  55                  60                  


Phe Val Ile Phe Phe Gln Lys Tyr Ser Gln Leu Leu Glu Lys Lys Thr 
65                  70                  75                  80  


Thr Lys Glu Leu Val His Thr Thr Leu Glu Cys Val Lys Lys Asn Met 
                85                  90                  95      


Pro Val Glu Glu Thr Ala Trp Ser Cys Cys Pro Lys Asn Trp Lys Ser 
            100                 105                 110         


Phe Ser Ser Asn Cys Tyr Phe Ile Ser Thr Glu Ser Ala Ser Trp Gln 
        115                 120                 125             


Asp Ser Glu Lys Asp Cys Ala Arg Met Glu Ala His Leu Leu Val Ile 
    130                 135                 140                 


Asn Thr Gln Glu Glu Gln Asp Phe Ile Phe Gln Asn Leu Gln Glu Glu 
145                 150                 155                 160 


Ser Ala Tyr Phe Val Gly Leu Ser Asp Pro Glu Gly Gln Arg His Trp 
                165                 170                 175     


Gln Trp Val Asp Gln Thr Pro Tyr Asn Glu Ser Ser Thr Phe Trp His 
            180                 185                 190         


Pro Arg Glu Pro Ser Asp Pro Asn Glu Arg Cys Val Val Leu Asn Phe 
        195                 200                 205             


Arg Lys Ser Pro Lys Arg Trp Gly Trp Asn Asp Val Asn Cys Leu Gly 
    210                 215                 220                 


Pro Gln Arg Ser Val Cys Glu Met Met Lys Ile His Leu 
225                 230                 235         


<210>  2267
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC4C__Homo_sapiens__NP_569708

<400>  2267

Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp 
1               5                   10                  15      


Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu 
            20                  25                  30          


Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn Phe Met Tyr 
        35                  40                  45              


Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr 
    50                  55                  60                  


His Pro Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp 
65                  70                  75                  80  


Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe 
                85                  90                  95      


Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser 
            100                 105                 110         


Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu Glu Gln Asp 
        115                 120                 125             


Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu 
    130                 135                 140                 


Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Thr Pro 
145                 150                 155                 160 


Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu 
                165                 170                 175     


Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp Gly 
            180                 185                 190         


Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met 
        195                 200                 205             


Lys Lys Ile Tyr Ile 
    210             


<210>  2268
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC4D__Homo_sapiens__NP_525126

<400>  2268

Met Gly Leu Glu Lys Pro Gln Ser Lys Leu Glu Gly Gly Met His Pro 
1               5                   10                  15      


Gln Leu Ile Pro Ser Val Ile Ala Val Val Phe Ile Leu Leu Leu Ser 
            20                  25                  30          


Val Cys Phe Ile Ala Ser Cys Leu Val Thr His His Asn Phe Ser Arg 
        35                  40                  45              


Cys Lys Arg Gly Thr Gly Val His Lys Leu Glu His His Ala Lys Leu 
    50                  55                  60                  


Lys Cys Ile Lys Glu Lys Ser Glu Leu Lys Ser Ala Glu Gly Ser Thr 
65                  70                  75                  80  


Trp Asn Cys Cys Pro Ile Asp Trp Arg Ala Phe Gln Ser Asn Cys Tyr 
                85                  90                  95      


Phe Pro Leu Thr Asp Asn Lys Thr Trp Ala Glu Ser Glu Arg Asn Cys 
            100                 105                 110         


Ser Gly Met Gly Ala His Leu Met Thr Ile Ser Thr Glu Ala Glu Gln 
        115                 120                 125             


Asn Phe Ile Ile Gln Phe Leu Asp Arg Arg Leu Ser Tyr Phe Leu Gly 
    130                 135                 140                 


Leu Arg Asp Glu Asn Ala Lys Gly Gln Trp Arg Trp Val Asp Gln Thr 
145                 150                 155                 160 


Pro Phe Asn Pro Arg Arg Val Phe Trp His Lys Asn Glu Pro Asp Asn 
                165                 170                 175     


Ser Gln Gly Glu Asn Cys Val Val Leu Val Tyr Asn Gln Asp Lys Trp 
            180                 185                 190         


Ala Trp Asn Asp Val Pro Cys Asn Phe Glu Ala Ser Arg Ile Cys Lys 
        195                 200                 205             


Ile Pro Gly Thr Thr Leu Asn 
    210                 215 


<210>  2269
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC4E__Homo_sapiens__NP_055173

<400>  2269

Met Asn Ser Ser Lys Ser Ser Glu Thr Gln Cys Thr Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Thr Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Thr Arg Cys Val Val Thr Phe Arg Ile 
        35                  40                  45              


Phe Gln Thr Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Thr 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ser Val Lys Asn Cys Cys 
65                  70                  75                  80  


Pro Leu Asn Trp Glu Tyr Phe Gln Ser Ser Cys Tyr Phe Phe Ser Thr 
                85                  90                  95      


Asp Thr Ile Ser Trp Ala Leu Ser Leu Lys Asn Cys Ser Ala Met Gly 
            100                 105                 110         


Ala His Leu Val Val Ile Asn Ser Gln Glu Glu Gln Glu Phe Leu Ser 
        115                 120                 125             


Tyr Lys Lys Pro Lys Met Arg Glu Phe Phe Ile Gly Leu Ser Asp Gln 
    130                 135                 140                 


Val Val Glu Gly Gln Trp Gln Trp Val Asp Gly Thr Pro Leu Thr Lys 
145                 150                 155                 160 


Ser Leu Ser Phe Trp Asp Val Gly Glu Pro Asn Asn Ile Ala Thr Leu 
                165                 170                 175     


Glu Asp Cys Ala Thr Met Arg Asp Ser Ser Asn Pro Arg Gln Asn Trp 
            180                 185                 190         


Asn Asp Val Thr Cys Phe Leu Asn Tyr Phe Arg Ile Cys Glu Met Val 
        195                 200                 205             


Gly Ile Asn Pro Leu Asn Lys Gly Lys Ser Leu 
    210                 215                 


<210>  2270
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC4G__Homo_sapiens__NP_001231785

<400>  2270

Met Asp Thr Thr Arg Tyr Arg Pro Trp Gly Arg Trp Val His Trp Ser 
1               5                   10                  15      


Arg Arg Pro Leu Phe Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu 
            20                  25                  30          


Trp Ala Val Ile Leu Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg 
        35                  40                  45              


Ala Ala Leu Leu Asp Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys 
    50                  55                  60                  


Gln Thr Ala Ala Leu Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His 
65                  70                  75                  80  


Ser Cys Cys Ser Gly Thr Gln Ala Gln Leu Gln Thr Thr Arg Ala Glu 
                85                  90                  95      


Leu Gly Glu Ala Gln Ala Lys Leu Met Glu Gln Glu Ser Ala Leu Arg 
            100                 105                 110         


Glu Leu Arg Glu Arg Val Thr Gln Gly Leu Ala Glu Ala Gly Arg Gly 
        115                 120                 125             


Arg Glu Asp Val Arg Thr Glu Leu Phe Arg Ala Leu Glu Ala Val Arg 
    130                 135                 140                 


Leu Gln Asn Asn Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Ser Phe 
145                 150                 155                 160 


Glu Gly Ser Cys Tyr Phe Phe Ser Val Pro Lys Thr Thr Trp Ala Ala 
                165                 170                 175     


Ala Gln Asp His Cys Ala Asp Ala Ser Ala His Leu Val Ile Val Gly 
            180                 185                 190         


Gly Leu Asp Glu Gln Gly Phe Leu Thr Arg Asn Thr Arg Gly Arg Gly 
        195                 200                 205             


Tyr Trp Leu Gly Leu Arg Ala Val Arg His Leu Gly Lys Val Gln Gly 
    210                 215                 220                 


Tyr Gln Trp Val Asp Gly Val Ser Leu Ser Phe Ser His Trp Asn Gln 
225                 230                 235                 240 


Gly Glu Pro Asn Asp Ala Trp Gly Arg Glu Asn Cys Val Met Met Leu 
                245                 250                 255     


His Thr Gly Leu Trp Asn Asp Ala Pro Cys Asp Ser Glu Lys Asp Gly 
            260                 265                 270         


Trp Ile Cys Glu Lys Arg His Asn Cys 
        275                 280     


<210>  2271
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC4M__Homo_sapiens__NP_001138376

<400>  2271

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Gly 
1               5                   10                  15      


Cys Leu Gly His Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu 
            20                  25                  30          


Leu Ala Gly Val Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro 
        35                  40                  45              


Ser Ser Leu Ser Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn 
    50                  55                  60                  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
65                  70                  75                  80  


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
                85                  90                  95      


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
            100                 105                 110         


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
        115                 120                 125             


Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu 
    130                 135                 140                 


Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Glu Leu 
145                 150                 155                 160 


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile 
                165                 170                 175     


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Asp 
            180                 185                 190         


Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu Thr Asp Leu Lys Thr 
        195                 200                 205             


Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp Thr Phe Phe 
    210                 215                 220                 


Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn Trp His Asp 
225                 230                 235                 240 


Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln Leu Val Val Ile Lys 
                245                 250                 255     


Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Thr Ser Arg Ser Asn 
            260                 265                 270         


Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu Gly Thr Trp 
        275                 280                 285             


Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln Arg Tyr Trp 
    290                 295                 300                 


Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys Ala Glu Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp Asn Tyr Trp 
                325                 330                 335     


Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
            340                 345             


<210>  2272
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC5A__Homo_sapiens__NP_037384

<400>  2272

Met Asn Trp His Met Ile Ile Ser Gly Leu Ile Val Val Val Leu Lys 
1               5                   10                  15      


Val Val Gly Met Thr Leu Phe Leu Leu Tyr Phe Pro Gln Ile Phe Asn 
            20                  25                  30          


Lys Ser Asn Asp Gly Phe Thr Thr Thr Arg Ser Tyr Gly Thr Val Ser 
        35                  40                  45              


Gln Ile Phe Gly Ser Ser Ser Pro Ser Pro Asn Gly Phe Ile Thr Thr 
    50                  55                  60                  


Arg Ser Tyr Gly Thr Val Cys Pro Lys Asp Trp Glu Phe Tyr Gln Ala 
65                  70                  75                  80  


Arg Cys Phe Phe Leu Ser Thr Ser Glu Ser Ser Trp Asn Glu Ser Arg 
                85                  90                  95      


Asp Phe Cys Lys Gly Lys Gly Ser Thr Leu Ala Ile Val Asn Thr Pro 
            100                 105                 110         


Glu Lys Leu Lys Phe Leu Gln Asp Ile Thr Asp Ala Glu Lys Tyr Phe 
        115                 120                 125             


Ile Gly Leu Ile Tyr His Arg Glu Glu Lys Arg Trp Arg Trp Ile Asn 
    130                 135                 140                 


Asn Ser Val Phe Asn Gly Asn Val Thr Asn Gln Asn Gln Asn Phe Asn 
145                 150                 155                 160 


Cys Ala Thr Ile Gly Leu Thr Lys Thr Phe Asp Ala Ala Ser Cys Asp 
                165                 170                 175     


Ile Ser Tyr Arg Arg Ile Cys Glu Lys Asn Ala Lys 
            180                 185             


<210>  2273
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC6A__Homo_sapiens__NP_001007034

<400>  2273

Met Met Gln Glu Gln Gln Pro Gln Ser Thr Glu Lys Arg Gly Trp Leu 
1               5                   10                  15      


Ser Leu Arg Leu Trp Ser Val Ala Gly Ile Ser Ile Ala Leu Leu Ser 
            20                  25                  30          


Ala Cys Phe Ile Val Ser Cys Val Val Thr Tyr His Phe Thr Tyr Gly 
        35                  40                  45              


Glu Thr Gly Lys Arg Leu Ser Glu Leu His Ser Tyr His Ser Ser Leu 
    50                  55                  60                  


Thr Cys Phe Ser Glu Gly Thr Lys Val Pro Ala Trp Gly Cys Cys Pro 
65                  70                  75                  80  


Ala Ser Trp Lys Ser Phe Gly Ser Ser Cys Tyr Phe Ile Ser Ser Glu 
                85                  90                  95      


Glu Lys Val Trp Ser Lys Ser Glu Gln Asn Cys Val Glu Met Gly Ala 
            100                 105                 110         


His Leu Val Val Phe Asn Thr Glu Ala Glu Gln Asn Phe Ile Val Gln 
        115                 120                 125             


Gln Leu Asn Glu Ser Phe Ser Tyr Phe Leu Gly Leu Ser Asp Pro Gln 
    130                 135                 140                 


Gly Asn Asn Asn Trp Gln Trp Ile Asp Lys Thr Pro Tyr Glu Lys Asn 
145                 150                 155                 160 


Val Arg Phe Trp His Leu Gly Glu Pro Asn His Ser Ala Glu Gln Cys 
                165                 170                 175     


Ala Ser Ile Val Phe Trp Lys Pro Thr Gly Trp Gly Trp Asn Asp Val 
            180                 185                 190         


Ile Cys Glu Thr Arg Arg Asn Ser Ile Cys Glu Met Asn Lys Ile Tyr 
        195                 200                 205             


Leu 
    


<210>  2274
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC7A__Homo_sapiens__NP_072092

<400>  2274

Met Glu Tyr His Pro Asp Leu Glu Asn Leu Asp Glu Asp Gly Tyr Thr 
1               5                   10                  15      


Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser 
            20                  25                  30          


Glu Lys Gly Ser Cys Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val 
        35                  40                  45              


Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile Ala Val Val Leu 
    50                  55                  60                  


Gly Thr Met Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile 
65                  70                  75                  80  


Tyr Glu Lys Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp 
                85                  90                  95      


Gly Ser Lys Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile 
            100                 105                 110         


Asp Ser Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln 
        115                 120                 125             


Pro Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val 
    130                 135                 140                 


Pro Trp Leu Trp Glu Asp Gly Ser Thr Phe Ser Ser Asn Leu Phe Gln 
145                 150                 155                 160 


Ile Arg Thr Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp 
                165                 170                 175     


Ile His Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr 
            180                 185                 190         


Ser Ile Cys Glu Lys Lys Phe Ser Met 
        195                 200     


<210>  2275
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC9A__Homo_sapiens__NP_997228

<400>  2275

Met His Glu Glu Glu Ile Tyr Thr Ser Leu Gln Trp Asp Ser Pro Ala 
1               5                   10                  15      


Pro Asp Thr Tyr Gln Lys Cys Leu Ser Ser Asn Lys Cys Ser Gly Ala 
            20                  25                  30          


Cys Cys Leu Val Met Val Ile Ser Cys Val Phe Cys Met Gly Leu Leu 
        35                  40                  45              


Thr Ala Ser Ile Phe Leu Gly Val Lys Leu Leu Gln Val Ser Thr Ile 
    50                  55                  60                  


Ala Met Gln Gln Gln Glu Lys Leu Ile Gln Gln Glu Arg Ala Leu Leu 
65                  70                  75                  80  


Asn Phe Thr Glu Trp Lys Arg Ser Cys Ala Leu Gln Met Lys Tyr Cys 
                85                  90                  95      


Gln Ala Phe Met Gln Asn Ser Leu Ser Ser Ala His Asn Ser Ser Pro 
            100                 105                 110         


Cys Pro Asn Asn Trp Ile Gln Asn Arg Glu Ser Cys Tyr Tyr Val Ser 
        115                 120                 125             


Glu Ile Trp Ser Ile Trp His Thr Ser Gln Glu Asn Cys Leu Lys Glu 
    130                 135                 140                 


Gly Ser Thr Leu Leu Gln Ile Glu Ser Lys Glu Glu Met Asp Phe Ile 
145                 150                 155                 160 


Thr Gly Ser Leu Arg Lys Ile Lys Gly Ser Tyr Asp Tyr Trp Val Gly 
                165                 170                 175     


Leu Ser Gln Asp Gly His Ser Gly Arg Trp Leu Trp Gln Asp Gly Ser 
            180                 185                 190         


Ser Pro Ser Pro Gly Leu Leu Pro Ala Glu Arg Ser Gln Ser Ala Asn 
        195                 200                 205             


Gln Val Cys Gly Tyr Val Lys Ser Asn Ser Leu Leu Ser Ser Asn Cys 
    210                 215                 220                 


Ser Thr Trp Lys Tyr Phe Ile Cys Glu Lys Tyr Ala Leu Arg Ser Ser 
225                 230                 235                 240 


Val 
    


<210>  2276
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLECL1__Homo_sapiens__NP_001240679

<400>  2276

Met Val Ser Asn Phe Phe His Val Ile Gln Val Phe Glu Lys Ser Ala 
1               5                   10                  15      


Thr Leu Ile Ser Lys Thr Glu His Ile Gly Phe Val Ile Tyr Ser Trp 
            20                  25                  30          


Arg Lys Ser Thr Thr His Leu Gly Ser Arg Arg Lys Phe Ala Ile Ser 
        35                  40                  45              


Ile Tyr Leu Ser Glu Val Ser Leu Gln Lys Tyr Asp Cys Pro Phe Ser 
    50                  55                  60                  


Gly Thr Ser Phe Val Val Phe Ser Leu Phe Leu Ile Cys Ala Met Ala 
65                  70                  75                  80  


Gly Asp Val Val Tyr Ala Asp Ile Lys Thr Val Arg Thr Ser Pro Leu 
                85                  90                  95      


Glu Leu Ala Phe Pro Leu Gln Arg Ser Val Ser Phe Asn Phe Ser Thr 
            100                 105                 110         


Val His Lys Ser Cys Pro Ala Lys Asp Trp Lys Val His Lys Gly Lys 
        115                 120                 125             


Cys Tyr Trp Ile Ala Glu Thr Lys Lys Ser Trp Asn Lys Ser Gln Asn 
    130                 135                 140                 


Asp Cys Ala Ile Asn Asn Ser Tyr Leu Met Val Ile Gln Asp Ile Thr 
145                 150                 155                 160 


Ala Met Leu Ile Thr Phe Leu Leu Tyr Leu Gln Met Ala Phe Leu Gln 
                165                 170                 175     


Cys Val Tyr Ile Ser Asp Val Ser Val Tyr Pro Asn Phe Phe Leu 
            180                 185                 190     


<210>  2277
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLGN__Homo_sapiens__NP_004353

<400>  2277

Met His Phe Gln Ala Phe Trp Leu Cys Leu Gly Leu Leu Phe Ile Ser 
1               5                   10                  15      


Ile Asn Ala Glu Phe Met Asp Asp Asp Val Glu Thr Glu Asp Phe Glu 
            20                  25                  30          


Glu Asn Ser Glu Glu Ile Asp Val Asn Glu Ser Glu Leu Ser Ser Glu 
        35                  40                  45              


Ile Lys Tyr Lys Thr Pro Gln Pro Ile Gly Glu Val Tyr Phe Ala Glu 
    50                  55                  60                  


Thr Phe Asp Ser Gly Arg Leu Ala Gly Trp Val Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Lys Asp Asp Met Asp Glu Glu Ile Ser Ile Tyr Asp Gly Arg Trp Glu 
                85                  90                  95      


Ile Glu Glu Leu Lys Glu Asn Gln Val Pro Gly Asp Arg Gly Leu Val 
            100                 105                 110         


Leu Lys Ser Arg Ala Lys His His Ala Ile Ser Ala Val Leu Ala Lys 
        115                 120                 125             


Pro Phe Ile Phe Ala Asp Lys Pro Leu Ile Val Gln Tyr Glu Val Asn 
    130                 135                 140                 


Phe Gln Asp Gly Ile Asp Cys Gly Gly Ala Tyr Ile Lys Leu Leu Ala 
145                 150                 155                 160 


Asp Thr Asp Asp Leu Ile Leu Glu Asn Phe Tyr Asp Lys Thr Ser Tyr 
                165                 170                 175     


Ile Ile Met Phe Gly Pro Asp Lys Cys Gly Glu Asp Tyr Lys Leu His 
            180                 185                 190         


Phe Ile Phe Arg His Lys His Pro Lys Thr Gly Val Phe Glu Glu Lys 
        195                 200                 205             


His Ala Lys Pro Pro Asp Val Asp Leu Lys Lys Phe Phe Thr Asp Arg 
    210                 215                 220                 


Lys Thr His Leu Tyr Thr Leu Val Met Asn Pro Asp Asp Thr Phe Glu 
225                 230                 235                 240 


Val Leu Val Asp Gln Thr Val Val Asn Lys Gly Ser Leu Leu Glu Asp 
                245                 250                 255     


Val Val Pro Pro Ile Lys Pro Pro Lys Glu Ile Glu Asp Pro Asn Asp 
            260                 265                 270         


Lys Lys Pro Glu Glu Trp Asp Glu Arg Ala Lys Ile Pro Asp Pro Ser 
        275                 280                 285             


Ala Val Lys Pro Glu Asp Trp Asp Glu Ser Glu Pro Ala Gln Ile Glu 
    290                 295                 300                 


Asp Ser Ser Val Val Lys Pro Ala Gly Trp Leu Asp Asp Glu Pro Lys 
305                 310                 315                 320 


Phe Ile Pro Asp Pro Asn Ala Glu Lys Pro Asp Asp Trp Asn Glu Asp 
                325                 330                 335     


Thr Asp Gly Glu Trp Glu Ala Pro Gln Ile Leu Asn Pro Ala Cys Arg 
            340                 345                 350         


Ile Gly Cys Gly Glu Trp Lys Pro Pro Met Ile Asp Asn Pro Lys Tyr 
        355                 360                 365             


Lys Gly Val Trp Arg Pro Pro Leu Val Asp Asn Pro Asn Tyr Gln Gly 
    370                 375                 380                 


Ile Trp Ser Pro Arg Lys Ile Pro Asn Pro Asp Tyr Phe Glu Asp Asp 
385                 390                 395                 400 


His Pro Phe Leu Leu Thr Ser Phe Ser Ala Leu Gly Leu Glu Leu Trp 
                405                 410                 415     


Ser Met Thr Ser Asp Ile Tyr Phe Asp Asn Phe Ile Ile Cys Ser Glu 
            420                 425                 430         


Lys Glu Val Ala Asp His Trp Ala Ala Asp Gly Trp Arg Trp Lys Ile 
        435                 440                 445             


Met Ile Ala Asn Ala Asn Lys Pro Gly Val Leu Lys Gln Leu Met Ala 
    450                 455                 460                 


Ala Ala Glu Gly His Pro Trp Leu Trp Leu Ile Tyr Leu Val Thr Ala 
465                 470                 475                 480 


Gly Val Pro Ile Ala Leu Ile Thr Ser Phe Cys Trp Pro Arg Lys Val 
                485                 490                 495     


Lys Lys Lys His Lys Asp Thr Glu Tyr Lys Lys Thr Asp Ile Cys Ile 
            500                 505                 510         


Pro Gln Thr Lys Gly Val Leu Glu Gln Glu Glu Lys Glu Glu Lys Ala 
        515                 520                 525             


Ala Leu Glu Lys Pro Met Asp Leu Glu Glu Glu Lys Lys Gln Asn Asp 
    530                 535                 540                 


Gly Glu Met Leu Glu Lys Glu Glu Glu Ser Glu Pro Glu Glu Lys Ser 
545                 550                 555                 560 


Glu Glu Glu Ile Glu Ile Ile Glu Gly Gln Glu Glu Ser Asn Gln Ser 
                565                 570                 575     


Asn Lys Ser Gly Ser Glu Asp Glu Met Lys Glu Ala Asp Glu Ser Thr 
            580                 585                 590         


Gly Ser Gly Asp Gly Pro Ile Lys Ser Val Arg Lys Arg Arg Val Arg 
        595                 600                 605             


Lys Asp 
    610 


<210>  2278
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLIC1__Homo_sapiens__NP_001279

<400>  2278

Met Ala Glu Glu Gln Pro Gln Val Glu Leu Phe Val Lys Ala Gly Ser 
1               5                   10                  15      


Asp Gly Ala Lys Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met 
            20                  25                  30          


Val Leu Trp Leu Lys Gly Val Thr Phe Asn Val Thr Thr Val Asp Thr 
        35                  40                  45              


Lys Arg Arg Thr Glu Thr Val Gln Lys Leu Cys Pro Gly Gly Gln Leu 
    50                  55                  60                  


Pro Phe Leu Leu Tyr Gly Thr Glu Val His Thr Asp Thr Asn Lys Ile 
65                  70                  75                  80  


Glu Glu Phe Leu Glu Ala Val Leu Cys Pro Pro Arg Tyr Pro Lys Leu 
                85                  90                  95      


Ala Ala Leu Asn Pro Glu Ser Asn Thr Ala Gly Leu Asp Ile Phe Ala 
            100                 105                 110         


Lys Phe Ser Ala Tyr Ile Lys Asn Ser Asn Pro Ala Leu Asn Asp Asn 
        115                 120                 125             


Leu Glu Lys Gly Leu Leu Lys Ala Leu Lys Val Leu Asp Asn Tyr Leu 
    130                 135                 140                 


Thr Ser Pro Leu Pro Glu Glu Val Asp Glu Thr Ser Ala Glu Asp Glu 
145                 150                 155                 160 


Gly Val Ser Gln Arg Lys Phe Leu Asp Gly Asn Glu Leu Thr Leu Ala 
                165                 170                 175     


Asp Cys Asn Leu Leu Pro Lys Leu His Ile Val Gln Val Val Cys Lys 
            180                 185                 190         


Lys Tyr Arg Gly Phe Thr Ile Pro Glu Ala Phe Arg Gly Val His Arg 
        195                 200                 205             


Tyr Leu Ser Asn Ala Tyr Ala Arg Glu Glu Phe Ala Ser Thr Cys Pro 
    210                 215                 220                 


Asp Asp Glu Glu Ile Glu Leu Ala Tyr Glu Gln Val Ala Lys Ala Leu 
225                 230                 235                 240 


Lys 
    


<210>  2279
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLIC3__Homo_sapiens__NP_004660

<400>  2279

Met Ala Glu Thr Lys Leu Gln Leu Phe Val Lys Ala Ser Glu Asp Gly 
1               5                   10                  15      


Glu Ser Val Gly His Cys Pro Ser Cys Gln Arg Leu Phe Met Val Leu 
            20                  25                  30          


Leu Leu Lys Gly Val Pro Phe Thr Leu Thr Thr Val Asp Thr Arg Arg 
        35                  40                  45              


Ser Pro Asp Val Leu Lys Asp Phe Ala Pro Gly Ser Gln Leu Pro Ile 
    50                  55                  60                  


Leu Leu Tyr Asp Ser Asp Ala Lys Thr Asp Thr Leu Gln Ile Glu Asp 
65                  70                  75                  80  


Phe Leu Glu Glu Thr Leu Gly Pro Pro Asp Phe Pro Ser Leu Ala Pro 
                85                  90                  95      


Arg Tyr Arg Glu Ser Asn Thr Ala Gly Asn Asp Val Phe His Lys Phe 
            100                 105                 110         


Ser Ala Phe Ile Lys Asn Pro Val Pro Ala Gln Asp Glu Ala Leu Tyr 
        115                 120                 125             


Gln Gln Leu Leu Arg Ala Leu Ala Arg Leu Asp Ser Tyr Leu Arg Ala 
    130                 135                 140                 


Pro Leu Glu His Glu Leu Ala Gly Glu Pro Gln Leu Arg Glu Ser Arg 
145                 150                 155                 160 


Arg Arg Phe Leu Asp Gly Asp Arg Leu Thr Leu Ala Asp Cys Ser Leu 
                165                 170                 175     


Leu Pro Lys Leu His Ile Val Asp Thr Val Cys Ala His Phe Arg Gln 
            180                 185                 190         


Ala Pro Ile Pro Ala Glu Leu Arg Gly Val Arg Arg Tyr Leu Asp Ser 
        195                 200                 205             


Ala Met Gln Glu Lys Glu Phe Lys Tyr Thr Cys Pro His Ser Ala Glu 
    210                 215                 220                 


Ile Leu Ala Ala Tyr Arg Pro Ala Val His Pro Arg 
225                 230                 235     


<210>  2280
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLIC5__Homo_sapiens__NP_001107558

<400>  2280

Met Asn Asp Glu Asp Tyr Ser Thr Ile Tyr Asp Thr Ile Gln Asn Glu 
1               5                   10                  15      


Arg Thr Tyr Glu Val Pro Asp Gln Pro Glu Glu Asn Glu Ser Pro His 
            20                  25                  30          


Tyr Asp Asp Val His Glu Tyr Leu Arg Pro Glu Asn Asp Leu Tyr Ala 
        35                  40                  45              


Thr Gln Leu Asn Thr His Glu Tyr Asp Phe Val Ser Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gly Glu Glu Thr Ser Leu Ala Ser Val Gln Ser Glu Asp Arg Gly 
65                  70                  75                  80  


Tyr Leu Leu Pro Asp Glu Ile Tyr Ser Glu Leu Gln Glu Ala His Pro 
                85                  90                  95      


Gly Glu Pro Gln Glu Asp Arg Gly Ile Ser Met Glu Gly Leu Tyr Ser 
            100                 105                 110         


Ser Thr Gln Asp Gln Gln Leu Cys Ala Ala Glu Leu Gln Glu Asn Gly 
        115                 120                 125             


Ser Val Met Lys Glu Asp Leu Pro Ser Pro Ser Ser Phe Thr Ile Gln 
    130                 135                 140                 


His Ser Lys Ala Phe Ser Thr Thr Lys Tyr Ser Cys Tyr Ser Asp Ala 
145                 150                 155                 160 


Glu Gly Leu Glu Glu Lys Glu Gly Ala His Met Asn Pro Glu Ile Tyr 
                165                 170                 175     


Leu Phe Val Lys Ala Gly Ile Asp Gly Glu Ser Ile Gly Asn Cys Pro 
            180                 185                 190         


Phe Ser Gln Arg Leu Phe Met Ile Leu Trp Leu Lys Gly Val Val Phe 
        195                 200                 205             


Asn Val Thr Thr Val Asp Leu Lys Arg Lys Pro Ala Asp Leu His Asn 
    210                 215                 220                 


Leu Ala Pro Gly Thr His Pro Pro Phe Leu Thr Phe Asn Gly Asp Val 
225                 230                 235                 240 


Lys Thr Asp Val Asn Lys Ile Glu Glu Phe Leu Glu Glu Thr Leu Thr 
                245                 250                 255     


Pro Glu Lys Tyr Pro Lys Leu Ala Ala Lys His Arg Glu Ser Asn Thr 
            260                 265                 270         


Ala Gly Ile Asp Ile Phe Ser Lys Phe Ser Ala Tyr Ile Lys Asn Thr 
        275                 280                 285             


Lys Gln Gln Asn Asn Ala Ala Leu Glu Arg Gly Leu Thr Lys Ala Leu 
    290                 295                 300                 


Lys Lys Leu Asp Asp Tyr Leu Asn Thr Pro Leu Pro Glu Glu Ile Asp 
305                 310                 315                 320 


Ala Asn Thr Cys Gly Glu Asp Lys Gly Ser Arg Arg Lys Phe Leu Asp 
                325                 330                 335     


Gly Asp Glu Leu Thr Leu Ala Asp Cys Asn Leu Leu Pro Lys Leu His 
            340                 345                 350         


Val Val Lys Ile Val Ala Lys Lys Tyr Arg Asn Tyr Asp Ile Pro Ala 
        355                 360                 365             


Glu Met Thr Gly Leu Trp Arg Tyr Leu Lys Asn Ala Tyr Ala Arg Asp 
    370                 375                 380                 


Glu Phe Thr Asn Thr Cys Ala Ala Asp Ser Glu Ile Glu Leu Ala Tyr 
385                 390                 395                 400 


Ala Asp Val Ala Lys Arg Leu Ser Arg Ser 
                405                 410 


<210>  2281
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLIC6__Homo_sapiens__NP_444507

<400>  2281

Met Ala Glu Ala Ala Glu Pro Glu Gly Val Ala Pro Gly Pro Gln Gly 
1               5                   10                  15      


Pro Pro Glu Val Pro Ala Pro Leu Ala Glu Arg Pro Gly Glu Pro Gly 
            20                  25                  30          


Ala Ala Gly Gly Glu Ala Glu Gly Pro Glu Gly Ser Glu Gly Ala Glu 
        35                  40                  45              


Glu Ala Pro Arg Gly Ala Ala Ala Val Lys Glu Ala Gly Gly Gly Gly 
    50                  55                  60                  


Pro Asp Arg Gly Pro Glu Ala Glu Ala Arg Gly Thr Arg Gly Ala His 
65                  70                  75                  80  


Gly Glu Thr Glu Ala Glu Glu Gly Ala Pro Glu Gly Ala Glu Val Pro 
                85                  90                  95      


Gln Gly Gly Glu Glu Thr Ser Gly Ala Gln Gln Val Glu Gly Ala Ser 
            100                 105                 110         


Pro Gly Arg Gly Ala Gln Gly Glu Pro Arg Gly Glu Ala Gln Arg Glu 
        115                 120                 125             


Pro Glu Asp Ser Ala Ala Pro Glu Arg Gln Glu Glu Ala Glu Gln Arg 
    130                 135                 140                 


Pro Glu Val Pro Glu Gly Ser Ala Ser Gly Glu Ala Gly Asp Ser Val 
145                 150                 155                 160 


Asp Ala Glu Gly Pro Leu Gly Asp Asn Ile Glu Ala Glu Gly Pro Ala 
                165                 170                 175     


Gly Asp Ser Val Glu Ala Glu Gly Arg Val Gly Asp Ser Val Asp Ala 
            180                 185                 190         


Glu Gly Pro Ala Gly Asp Ser Val Asp Ala Glu Gly Pro Leu Gly Asp 
        195                 200                 205             


Asn Ile Gln Ala Glu Gly Pro Ala Gly Asp Ser Val Asp Ala Glu Gly 
    210                 215                 220                 


Arg Val Gly Asp Ser Val Asp Ala Glu Gly Pro Ala Gly Asp Ser Val 
225                 230                 235                 240 


Asp Ala Glu Gly Arg Val Gly Asp Ser Val Glu Ala Gly Asp Pro Ala 
                245                 250                 255     


Gly Asp Gly Val Glu Ala Gly Val Pro Ala Gly Asp Ser Val Glu Ala 
            260                 265                 270         


Glu Gly Pro Ala Gly Asp Ser Met Asp Ala Glu Gly Pro Ala Gly Arg 
        275                 280                 285             


Ala Arg Arg Val Ser Gly Glu Pro Gln Gln Ser Gly Asp Gly Ser Leu 
    290                 295                 300                 


Ser Pro Gln Ala Glu Ala Ile Glu Val Ala Ala Gly Glu Ser Ala Gly 
305                 310                 315                 320 


Arg Ser Pro Gly Glu Leu Ala Trp Asp Ala Ala Glu Glu Ala Glu Val 
                325                 330                 335     


Pro Gly Val Lys Gly Ser Glu Glu Ala Ala Pro Gly Asp Ala Arg Ala 
            340                 345                 350         


Asp Ala Gly Glu Asp Arg Val Gly Asp Gly Pro Gln Gln Glu Pro Gly 
        355                 360                 365             


Glu Asp Glu Glu Arg Arg Glu Arg Ser Pro Glu Gly Pro Arg Glu Glu 
    370                 375                 380                 


Glu Ala Ala Gly Gly Glu Glu Glu Ser Pro Asp Ser Ser Pro His Gly 
385                 390                 395                 400 


Glu Ala Ser Arg Gly Ala Ala Glu Pro Glu Ala Gln Leu Ser Asn His 
                405                 410                 415     


Leu Ala Glu Glu Gly Pro Ala Glu Gly Ser Gly Glu Ala Ala Arg Val 
            420                 425                 430         


Asn Gly Arg Arg Glu Asp Gly Glu Ala Ser Glu Pro Arg Ala Leu Gly 
        435                 440                 445             


Gln Glu His Asp Ile Thr Leu Phe Val Lys Ala Gly Tyr Asp Gly Glu 
    450                 455                 460                 


Ser Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp 
465                 470                 475                 480 


Leu Lys Gly Val Ile Phe Asn Val Thr Thr Val Asp Leu Lys Arg Lys 
                485                 490                 495     


Pro Ala Asp Leu Gln Asn Leu Ala Pro Gly Thr Asn Pro Pro Phe Met 
            500                 505                 510         


Thr Phe Asp Gly Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe 
        515                 520                 525             


Leu Glu Glu Lys Leu Ala Pro Pro Arg Tyr Pro Lys Leu Gly Thr Gln 
    530                 535                 540                 


His Pro Glu Ser Asn Ser Ala Gly Asn Asp Val Phe Ala Lys Phe Ser 
545                 550                 555                 560 


Ala Phe Ile Lys Asn Thr Lys Lys Asp Ala Asn Glu Ile His Glu Lys 
                565                 570                 575     


Asn Leu Leu Lys Ala Leu Arg Lys Leu Asp Asn Tyr Leu Asn Ser Pro 
            580                 585                 590         


Leu Pro Asp Glu Ile Asp Ala Tyr Ser Thr Glu Asp Val Thr Val Ser 
        595                 600                 605             


Gly Arg Lys Phe Leu Asp Gly Asp Glu Leu Thr Leu Ala Asp Cys Asn 
    610                 615                 620                 


Leu Leu Pro Lys Leu His Ile Ile Lys Ile Val Ala Lys Lys Tyr Arg 
625                 630                 635                 640 


Asp Phe Glu Phe Pro Ser Glu Met Thr Gly Ile Trp Arg Tyr Leu Asn 
                645                 650                 655     


Asn Ala Tyr Ala Arg Asp Glu Phe Thr Asn Thr Cys Pro Ala Asp Gln 
            660                 665                 670         


Glu Ile Glu His Ala Tyr Ser Asp Val Ala Lys Arg Met Lys 
        675                 680                 685     


<210>  2282
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLINT1__Homo_sapiens__NP_001182484

<400>  2282

Met Leu Asn Met Trp Lys Val Arg Glu Leu Val Asp Lys Ala Thr Asn 
1               5                   10                  15      


Val Val Met Asn Tyr Ser Glu Ile Glu Ser Lys Val Arg Glu Ala Thr 
            20                  25                  30          


Asn Asp Asp Pro Trp Gly Pro Ser Gly Gln Leu Met Gly Glu Ile Ala 
        35                  40                  45              


Lys Ala Thr Phe Met Tyr Glu Gln Phe Pro Glu Leu Met Asn Met Leu 
    50                  55                  60                  


Trp Ser Arg Met Leu Lys Asp Asn Lys Lys Asn Trp Arg Arg Val Tyr 
65                  70                  75                  80  


Lys Ser Leu Leu Leu Leu Ala Tyr Leu Ile Arg Asn Gly Ser Glu Arg 
                85                  90                  95      


Val Val Thr Ser Ala Arg Glu His Ile Tyr Asp Leu Arg Ser Leu Glu 
            100                 105                 110         


Asn Tyr His Phe Val Asp Glu His Gly Lys Asp Gln Gly Ile Asn Ile 
        115                 120                 125             


Arg Gln Lys Val Lys Glu Leu Val Glu Phe Ala Gln Asp Asp Asp Arg 
    130                 135                 140                 


Leu Arg Glu Glu Arg Lys Lys Ala Lys Lys Asn Lys Asp Lys Tyr Val 
145                 150                 155                 160 


Gly Val Ser Ser Asp Ser Val Gly Gly Phe Arg Tyr Ser Glu Arg Tyr 
                165                 170                 175     


Asp Pro Glu Pro Lys Ser Lys Trp Asp Glu Glu Trp Asp Lys Asn Lys 
            180                 185                 190         


Ser Ala Phe Pro Phe Ser Asp Lys Leu Gly Glu Leu Ser Asp Lys Ile 
        195                 200                 205             


Gly Ser Thr Ile Asp Asp Thr Ile Ser Lys Phe Arg Arg Lys Asp Arg 
    210                 215                 220                 


Glu Asp Ser Pro Glu Arg Cys Ser Asp Ser Asp Glu Glu Lys Lys Ala 
225                 230                 235                 240 


Arg Arg Gly Arg Ser Pro Lys Gly Glu Phe Lys Asp Glu Glu Glu Thr 
                245                 250                 255     


Val Thr Thr Lys His Ile His Ile Thr Gln Ala Thr Glu Thr Thr Thr 
            260                 265                 270         


Thr Arg His Lys Arg Thr Ala Asn Pro Ser Lys Thr Ile Asp Leu Gly 
        275                 280                 285             


Ala Ala Ala His Tyr Thr Gly Asp Lys Ala Ser Pro Asp Gln Asn Ala 
    290                 295                 300                 


Ser Thr His Thr Pro Gln Ser Ser Val Lys Thr Ser Val Pro Ser Ser 
305                 310                 315                 320 


Lys Ser Ser Gly Asp Leu Val Asp Leu Phe Asp Gly Thr Ser Gln Ser 
                325                 330                 335     


Thr Gly Gly Ser Ala Asp Leu Phe Gly Gly Phe Ala Asp Phe Gly Ser 
            340                 345                 350         


Ala Ala Ala Ser Gly Ser Phe Pro Ser Gln Val Thr Ala Thr Ser Gly 
        355                 360                 365             


Asn Gly Asp Phe Gly Asp Trp Ser Ala Phe Asn Gln Ala Pro Ser Gly 
    370                 375                 380                 


Pro Val Ala Ser Ser Gly Glu Phe Phe Gly Ser Ala Ser Gln Pro Ala 
385                 390                 395                 400 


Val Glu Leu Val Ser Gly Ser Gln Ser Ala Leu Gly Pro Pro Pro Ala 
                405                 410                 415     


Ala Ser Asn Ser Ser Asp Leu Phe Asp Leu Met Gly Ser Ser Gln Ala 
            420                 425                 430         


Thr Met Thr Ser Ser Gln Ser Met Asn Phe Ser Met Met Ser Thr Asn 
        435                 440                 445             


Thr Val Gly Leu Gly Leu Pro Met Ser Arg Ser Gln Pro Leu Gln Asn 
    450                 455                 460                 


Val Ser Thr Val Leu Gln Lys Pro Asn Pro Leu Tyr Asn Gln Asn Thr 
465                 470                 475                 480 


Asp Met Val Gln Lys Ser Val Ser Lys Thr Leu Pro Ser Thr Trp Ser 
                485                 490                 495     


Asp Pro Ser Val Asn Ile Ser Leu Asp Asn Leu Leu Pro Gly Met Gln 
            500                 505                 510         


Pro Ser Lys Pro Gln Gln Pro Ser Leu Asn Thr Met Ile Gln Gln Gln 
        515                 520                 525             


Asn Met Gln Gln Pro Met Asn Val Met Thr Gln Ser Phe Gly Ala Val 
    530                 535                 540                 


Asn Leu Ser Ser Pro Ser Asn Met Leu Pro Val Arg Pro Gln Thr Asn 
545                 550                 555                 560 


Ala Leu Ile Gly Gly Pro Met Pro Met Ser Met Pro Asn Val Met Thr 
                565                 570                 575     


Gly Thr Met Gly Met Ala Pro Leu Gly Asn Thr Pro Met Met Asn Gln 
            580                 585                 590         


Ser Met Met Gly Met Asn Met Asn Ile Gly Met Ser Ala Ala Gly Met 
        595                 600                 605             


Gly Leu Thr Gly Thr Met Gly Met Gly Met Pro Asn Ile Ala Met Thr 
    610                 615                 620                 


Ser Gly Thr Val Gln Pro Lys Gln Asp Ala Phe Ala Asn Phe Ala Asn 
625                 630                 635                 640 


Phe Ser Lys 
            


<210>  2283
<211>  1438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLIP1__Homo_sapiens__NP_001234926

<400>  2283

Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15      


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30          


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45              


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60                  


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80  


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95      


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110         


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125             


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140                 


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160 


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175     


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190         


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205             


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220                 


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240 


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255     


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270         


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285             


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300                 


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320 


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 
                325                 330                 335     


Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala 
            340                 345                 350         


Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu Leu 
        355                 360                 365             


Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser His 
    370                 375                 380                 


Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala Arg Asp Gly His Asp 
385                 390                 395                 400 


Gln His Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met 
                405                 410                 415     


Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 
            420                 425                 430         


Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 
        435                 440                 445             


Ser Ile Thr Lys Gly Asp Leu Glu Gln Lys Ser Gln Ile Ser Glu Asp 
    450                 455                 460                 


Pro Glu Asn Thr Gln Thr Lys Leu Glu His Ala Arg Ile Lys Glu Leu 
465                 470                 475                 480 


Glu Gln Ser Leu Leu Phe Glu Lys Thr Lys Ala Asp Lys Leu Gln Arg 
                485                 490                 495     


Glu Leu Glu Asp Thr Arg Val Ala Thr Val Ser Glu Lys Ser Arg Ile 
            500                 505                 510         


Met Glu Leu Glu Lys Asp Leu Ala Leu Arg Val Gln Glu Val Ala Glu 
        515                 520                 525             


Leu Arg Arg Arg Leu Glu Ser Asn Lys Pro Ala Gly Asp Val Asp Met 
    530                 535                 540                 


Ser Leu Ser Leu Leu Gln Glu Ile Ser Ser Leu Gln Glu Lys Leu Glu 
545                 550                 555                 560 


Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr Ser Leu Lys Glu His 
                565                 570                 575     


Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu Ile Lys Ala Leu Tyr 
            580                 585                 590         


Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu Ser Leu Lys Ser Lys 
        595                 600                 605             


Leu Glu His Ala Asn Lys Glu Asn Ser Asp Val Ile Ala Leu Trp Lys 
    610                 615                 620                 


Ser Lys Leu Glu Thr Ala Ile Ala Ser His Gln Gln Ala Met Glu Glu 
625                 630                 635                 640 


Leu Lys Val Ser Phe Ser Lys Gly Leu Gly Thr Glu Thr Ala Glu Phe 
                645                 650                 655     


Ala Glu Leu Lys Thr Gln Ile Glu Lys Met Arg Leu Asp Tyr Gln His 
            660                 665                 670         


Glu Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser Glu Arg Ala Ala His 
        675                 680                 685             


Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu Met Lys Val Ile Lys 
    690                 695                 700                 


Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser Lys Leu Asp Lys Ala 
705                 710                 715                 720 


Glu Asp Gln His Leu Val Glu Met Glu Asp Thr Leu Asn Lys Leu Gln 
                725                 730                 735     


Glu Ala Glu Ile Lys Val Lys Glu Leu Glu Val Leu Gln Ala Lys Cys 
            740                 745                 750         


Asn Glu Gln Thr Lys Val Ile Asp Asn Phe Thr Ser Gln Leu Lys Ala 
        755                 760                 765             


Thr Glu Glu Lys Leu Leu Asp Leu Asp Ala Leu Arg Lys Ala Ser Ser 
    770                 775                 780                 


Glu Gly Lys Ser Glu Met Lys Lys Leu Arg Gln Gln Leu Glu Ala Ala 
785                 790                 795                 800 


Glu Lys Gln Ile Lys His Leu Glu Ile Glu Lys Asn Ala Glu Ser Ser 
                805                 810                 815     


Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly Arg Glu Leu Lys Leu 
            820                 825                 830         


Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser Gln Val Lys Glu Thr 
        835                 840                 845             


Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys Phe Ala Glu Ala Ser 
    850                 855                 860                 


Glu Glu Ala Val Ser Val Gln Arg Ser Met Gln Glu Thr Val Asn Lys 
865                 870                 875                 880 


Leu His Gln Lys Glu Glu Gln Phe Asn Met Leu Ser Ser Asp Leu Glu 
                885                 890                 895     


Lys Leu Arg Glu Asn Leu Ala Asp Met Glu Ala Lys Phe Arg Glu Lys 
            900                 905                 910         


Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys Glu Lys Leu Glu Asn 
        915                 920                 925             


Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp Asn Ser Ser Gln Leu 
    930                 935                 940                 


Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu Arg Asp Val Glu Glu 
945                 950                 955                 960 


Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn Ala Ser Phe Leu Gln 
                965                 970                 975     


Lys Ser Ile Glu Asp Met Thr Val Lys Ala Glu Gln Ser Gln Gln Glu 
            980                 985                 990         


Ala Ala Lys Lys His Glu Glu Glu  Lys Lys Glu Leu Glu  Arg Lys Leu 
        995                 1000                 1005             


Ser Asp  Leu Glu Lys Lys Met  Glu Thr Ser His Asn  Gln Cys Gln 
    1010                 1015                 1020             


Glu Leu  Lys Ala Arg Tyr Glu  Arg Ala Thr Ser Glu  Thr Lys Thr 
    1025                 1030                 1035             


Lys His  Glu Glu Ile Leu Gln  Asn Leu Gln Lys Thr  Leu Leu Asp 
    1040                 1045                 1050             


Thr Glu  Asp Lys Leu Lys Gly  Ala Arg Glu Glu Asn  Ser Gly Leu 
    1055                 1060                 1065             


Leu Gln  Glu Leu Glu Glu Leu  Arg Lys Gln Ala Asp  Lys Ala Lys 
    1070                 1075                 1080             


Ala Ala  Gln Thr Ala Glu Asp  Ala Met Gln Ile Met  Glu Gln Met 
    1085                 1090                 1095             


Thr Lys  Glu Lys Thr Glu Thr  Leu Ala Ser Leu Glu  Asp Thr Lys 
    1100                 1105                 1110             


Gln Thr  Asn Ala Lys Leu Gln  Asn Glu Leu Asp Thr  Leu Lys Glu 
    1115                 1120                 1125             


Asn Asn  Leu Lys Asn Val Glu  Glu Leu Asn Lys Ser  Lys Glu Leu 
    1130                 1135                 1140             


Leu Thr  Val Glu Asn Gln Lys  Met Glu Glu Phe Arg  Lys Glu Ile 
    1145                 1150                 1155             


Glu Thr  Leu Lys Gln Ala Ala  Ala Gln Lys Ser Gln  Gln Leu Ser 
    1160                 1165                 1170             


Ala Leu  Gln Glu Glu Asn Val  Lys Leu Ala Glu Glu  Leu Gly Arg 
    1175                 1180                 1185             


Ser Arg  Asp Glu Val Thr Ser  His Gln Lys Leu Glu  Glu Glu Arg 
    1190                 1195                 1200             


Ser Val  Leu Asn Asn Gln Leu  Leu Glu Met Lys Lys  Arg Glu Ser 
    1205                 1210                 1215             


Lys Phe  Ile Lys Asp Ala Asp  Glu Glu Lys Ala Ser  Leu Gln Lys 
    1220                 1225                 1230             


Ser Ile  Ser Ile Thr Ser Ala  Leu Leu Thr Glu Lys  Asp Ala Glu 
    1235                 1240                 1245             


Leu Glu  Lys Leu Arg Asn Glu  Val Thr Val Leu Arg  Gly Glu Asn 
    1250                 1255                 1260             


Ala Ser  Ala Lys Ser Leu His  Ser Val Val Gln Thr  Leu Glu Ser 
    1265                 1270                 1275             


Asp Lys  Val Lys Leu Glu Leu  Lys Val Lys Asn Leu  Glu Leu Gln 
    1280                 1285                 1290             


Leu Lys  Glu Asn Lys Arg Gln  Leu Ser Ser Ser Ser  Gly Asn Thr 
    1295                 1300                 1305             


Asp Thr  Gln Ala Asp Glu Asp  Glu Arg Ala Gln Glu  Ser Gln Ile 
    1310                 1315                 1320             


Asp Phe  Leu Asn Ser Val Ile  Val Asp Leu Gln Arg  Lys Asn Gln 
    1325                 1330                 1335             


Asp Leu  Lys Met Lys Val Glu  Met Met Ser Glu Ala  Ala Leu Asn 
    1340                 1345                 1350             


Gly Asn  Gly Asp Asp Leu Asn  Asn Tyr Asp Ser Asp  Asp Gln Glu 
    1355                 1360                 1365             


Lys Gln  Ser Lys Lys Lys Pro  Arg Leu Phe Cys Asp  Ile Cys Asp 
    1370                 1375                 1380             


Cys Phe  Asp Leu His Asp Thr  Glu Asp Cys Pro Thr  Gln Ala Gln 
    1385                 1390                 1395             


Met Ser  Glu Asp Pro Pro His  Ser Thr His His Gly  Ser Arg Gly 
    1400                 1405                 1410             


Glu Glu  Arg Pro Tyr Cys Glu  Ile Cys Glu Met Phe  Gly His Trp 
    1415                 1420                 1425             


Ala Thr  Asn Cys Asn Asp Asp  Glu Thr Phe 
    1430                 1435             


<210>  2284
<211>  1046
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLIP2__Homo_sapiens__NP_003379

<400>  2284

Met Gln Lys Pro Ser Gly Leu Lys Pro Pro Gly Arg Gly Gly Lys His 
1               5                   10                  15      


Ser Ser Pro Met Gly Arg Thr Ser Thr Gly Ser Ala Ser Ser Ser Ala 
            20                  25                  30          


Ala Val Ala Ala Ser Ser Lys Glu Gly Ser Pro Leu His Lys Gln Ser 
        35                  40                  45              


Ser Gly Pro Ser Ser Ser Pro Ala Ala Ala Ala Ala Pro Glu Lys Pro 
    50                  55                  60                  


Gly Pro Lys Ala Ala Glu Val Gly Asp Asp Phe Leu Gly Asp Phe Val 
65                  70                  75                  80  


Val Gly Glu Arg Val Trp Val Asn Gly Val Lys Pro Gly Val Val Gln 
                85                  90                  95      


Tyr Leu Gly Glu Thr Gln Phe Ala Pro Gly Gln Trp Ala Gly Val Val 
            100                 105                 110         


Leu Asp Asp Pro Val Gly Lys Asn Asp Gly Ala Val Gly Gly Val Arg 
        115                 120                 125             


Tyr Phe Glu Cys Pro Ala Leu Gln Gly Ile Phe Thr Arg Pro Ser Lys 
    130                 135                 140                 


Leu Thr Arg Gln Pro Thr Ala Glu Gly Ser Gly Ser Asp Ala His Ser 
145                 150                 155                 160 


Val Glu Ser Leu Thr Ala Gln Asn Leu Ser Leu His Ser Gly Thr Ala 
                165                 170                 175     


Thr Pro Pro Leu Thr Ser Arg Val Ile Pro Leu Arg Glu Ser Val Leu 
            180                 185                 190         


Asn Ser Ser Val Lys Thr Gly Asn Glu Ser Gly Ser Asn Leu Ser Asp 
        195                 200                 205             


Ser Gly Ser Val Lys Arg Gly Glu Lys Asp Leu Arg Leu Gly Asp Arg 
    210                 215                 220                 


Val Leu Val Gly Gly Thr Lys Thr Gly Val Val Arg Tyr Val Gly Glu 
225                 230                 235                 240 


Thr Asp Phe Ala Lys Gly Glu Trp Cys Gly Val Glu Leu Asp Glu Pro 
                245                 250                 255     


Leu Gly Lys Asn Asp Gly Ala Val Ala Gly Thr Arg Tyr Phe Gln Cys 
            260                 265                 270         


Pro Pro Lys Phe Gly Leu Phe Ala Pro Ile His Lys Val Ile Arg Ile 
        275                 280                 285             


Gly Phe Pro Ser Thr Ser Pro Ala Lys Ala Lys Lys Thr Lys Arg Met 
    290                 295                 300                 


Ala Met Gly Val Ser Ala Leu Thr His Ser Pro Ser Ser Ser Ser Ile 
305                 310                 315                 320 


Ser Ser Val Ser Ser Val Ala Ser Ser Val Gly Gly Arg Pro Ser Arg 
                325                 330                 335     


Ser Gly Leu Leu Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser 
            340                 345                 350         


Gly Thr Thr Ala Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile 
        355                 360                 365             


Glu Gln Leu Leu Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys 
    370                 375                 380                 


Ala Thr Ser His Ile Cys Glu Val Glu Lys Glu Ile Ala Leu Leu Lys 
385                 390                 395                 400 


Ala Gln His Glu Gln Tyr Val Ala Glu Ala Glu Glu Lys Leu Gln Arg 
                405                 410                 415     


Ala Arg Leu Leu Val Glu Ser Val Arg Lys Glu Lys Val Asp Leu Ser 
            420                 425                 430         


Asn Gln Leu Glu Glu Glu Arg Arg Lys Val Glu Asp Leu Gln Phe Arg 
        435                 440                 445             


Val Glu Glu Glu Ser Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Gln 
    450                 455                 460                 


Leu Glu His Ala Arg Ile Gly Glu Leu Glu Gln Ser Leu Leu Leu Glu 
465                 470                 475                 480 


Lys Ala Gln Ala Glu Arg Leu Leu Arg Glu Leu Ala Asp Asn Arg Leu 
                485                 490                 495     


Thr Thr Val Ala Glu Lys Ser Arg Val Leu Gln Leu Glu Glu Glu Leu 
            500                 505                 510         


Thr Leu Arg Arg Gly Glu Ile Glu Glu Leu Gln Gln Cys Leu Leu His 
        515                 520                 525             


Ser Gly Pro Pro Pro Pro Asp His Pro Asp Ala Ala Glu Ile Leu Arg 
    530                 535                 540                 


Leu Arg Glu Arg Leu Leu Ser Ala Ser Lys Glu His Gln Arg Glu Ser 
545                 550                 555                 560 


Gly Val Leu Arg Asp Lys Tyr Glu Lys Ala Leu Lys Ala Tyr Gln Ala 
                565                 570                 575     


Glu Val Asp Lys Leu Arg Ala Ala Asn Glu Lys Tyr Ala Gln Glu Val 
            580                 585                 590         


Ala Gly Leu Lys Asp Lys Val Gln Gln Ala Thr Ser Glu Asn Met Gly 
        595                 600                 605             


Leu Met Asp Asn Trp Lys Ser Lys Leu Asp Ser Leu Ala Ser Asp His 
    610                 615                 620                 


Gln Lys Ser Leu Glu Asp Leu Lys Ala Thr Leu Asn Ser Gly Pro Gly 
625                 630                 635                 640 


Ala Gln Gln Lys Glu Ile Gly Glu Leu Lys Ala Val Met Glu Gly Ile 
                645                 650                 655     


Lys Met Glu His Gln Leu Glu Leu Gly Asn Leu Gln Ala Lys His Asp 
            660                 665                 670         


Leu Glu Thr Ala Met His Val Lys Glu Lys Glu Ala Leu Arg Glu Lys 
        675                 680                 685             


Leu Gln Glu Ala Gln Glu Glu Leu Ala Gly Leu Gln Arg His Trp Arg 
    690                 695                 700                 


Ala Gln Leu Glu Val Gln Ala Ser Gln His Arg Leu Glu Leu Gln Glu 
705                 710                 715                 720 


Ala Gln Asp Gln Arg Arg Asp Ala Glu Leu Arg Val His Glu Leu Glu 
                725                 730                 735     


Lys Leu Asp Val Glu Tyr Arg Gly Gln Ala Gln Ala Ile Glu Phe Leu 
            740                 745                 750         


Lys Glu Gln Ile Ser Leu Ala Glu Lys Lys Met Leu Asp Tyr Glu Arg 
        755                 760                 765             


Leu Gln Arg Ala Glu Ala Gln Gly Lys Gln Glu Val Glu Ser Leu Arg 
    770                 775                 780                 


Glu Lys Leu Leu Val Ala Glu Asn Arg Leu Gln Ala Val Glu Ala Leu 
785                 790                 795                 800 


Cys Ser Ser Gln His Thr His Met Ile Glu Ser Asn Asp Ile Ser Glu 
                805                 810                 815     


Glu Thr Ile Arg Thr Lys Glu Thr Val Glu Gly Leu Gln Asp Lys Leu 
            820                 825                 830         


Asn Lys Arg Asp Lys Glu Val Thr Ala Leu Thr Ser Gln Thr Glu Met 
        835                 840                 845             


Leu Arg Ala Gln Val Ser Ala Leu Glu Ser Lys Cys Lys Ser Gly Glu 
    850                 855                 860                 


Lys Lys Val Asp Ala Leu Leu Lys Glu Lys Arg Arg Leu Glu Ala Glu 
865                 870                 875                 880 


Leu Glu Thr Val Ser Arg Lys Thr His Asp Ala Ser Gly Gln Leu Val 
                885                 890                 895     


Leu Ile Ser Gln Glu Leu Leu Arg Lys Glu Arg Ser Leu Asn Glu Leu 
            900                 905                 910         


Arg Val Leu Leu Leu Glu Ala Asn Arg His Ser Pro Gly Pro Glu Arg 
        915                 920                 925             


Asp Leu Ser Arg Glu Val His Lys Ala Glu Trp Arg Ile Lys Glu Gln 
    930                 935                 940                 


Lys Leu Lys Asp Asp Ile Arg Gly Leu Arg Glu Lys Leu Thr Gly Leu 
945                 950                 955                 960 


Asp Lys Glu Lys Ser Leu Ser Asp Gln Arg Arg Tyr Ser Leu Ile Asp 
                965                 970                 975     


Pro Ser Ser Ala Pro Glu Leu Leu Arg Leu Gln His Gln Leu Met Ser 
            980                 985                 990         


Thr Glu Asp Ala Leu Arg Asp Ala  Leu Asp Gln Ala Gln  Gln Val Glu 
        995                 1000                 1005             


Lys Leu  Met Glu Ala Met Arg  Ser Cys Pro Asp Lys  Ala Gln Thr 
    1010                 1015                 1020             


Ile Gly  Asn Ser Gly Ser Ala  Asn Gly Ile His Gln  Gln Asp Lys 
    1025                 1030                 1035             


Ala Gln  Lys Gln Glu Asp Lys  His 
    1040                 1045     


<210>  2285
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLK1__Homo_sapiens__NP_001155879

<400>  2285

Met Ala Ala Gly Arg Arg Pro Ala Ser Ala Leu Trp Pro Glu Arg Arg 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Asp Leu Leu Gly Phe Gln Asn Val Arg Glu 
            20                  25                  30          


Pro Ser Ser Cys Gly Glu Thr Leu Ser Gly Met Arg His Ser Lys Arg 
        35                  40                  45              


Thr Tyr Cys Pro Asp Trp Asp Asp Lys Asp Trp Asp Tyr Gly Lys Trp 
    50                  55                  60                  


Arg Ser Ser Ser Ser His Lys Arg Arg Lys Arg Ser His Ser Ser Ala 
65                  70                  75                  80  


Gln Glu Asn Lys Arg Cys Lys Tyr Asn His Ser Lys Met Cys Asp Ser 
                85                  90                  95      


His Tyr Leu Glu Ser Arg Ser Ile Asn Glu Lys Asp Tyr His Ser Arg 
            100                 105                 110         


Arg Tyr Ile Asp Glu Tyr Arg Asn Asp Tyr Thr Gln Gly Cys Glu Pro 
        115                 120                 125             


Gly His Arg Gln Arg Asp His Glu Ser Arg Tyr Gln Asn His Ser Ser 
    130                 135                 140                 


Lys Ser Ser Gly Arg Ser Gly Arg Ser Ser Tyr Lys Ser Lys His Arg 
145                 150                 155                 160 


Ile His His Ser Thr Ser His Arg Arg Ser His Gly Lys Ser His Arg 
                165                 170                 175     


Arg Lys Arg Thr Arg Ser Val Glu Asp Asp Glu Glu Gly His Leu Ile 
            180                 185                 190         


Cys Gln Ser Gly Asp Val Leu Ser Ala Arg Tyr Glu Ile Val Asp Thr 
        195                 200                 205             


Leu Gly Glu Gly Ala Phe Gly Lys Val Val Glu Cys Ile Asp His Lys 
    210                 215                 220                 


Ala Gly Gly Arg His Val Ala Val Lys Ile Val Lys Asn Val Asp Arg 
225                 230                 235                 240 


Tyr Cys Glu Ala Ala Arg Ser Glu Ile Gln Val Leu Glu His Leu Asn 
                245                 250                 255     


Thr Thr Asp Pro Asn Ser Thr Phe Arg Cys Val Gln Met Leu Glu Trp 
            260                 265                 270         


Phe Glu His His Gly His Ile Cys Ile Val Phe Glu Leu Leu Gly Leu 
        275                 280                 285             


Ser Thr Tyr Asp Phe Ile Lys Glu Asn Gly Phe Leu Pro Phe Arg Leu 
    290                 295                 300                 


Asp His Ile Arg Lys Met Ala Tyr Gln Ile Cys Lys Ser Val Asn Phe 
305                 310                 315                 320 


Leu His Ser Asn Lys Leu Thr His Thr Asp Leu Lys Pro Glu Asn Ile 
                325                 330                 335     


Leu Phe Val Gln Ser Asp Tyr Thr Glu Ala Tyr Asn Pro Lys Ile Lys 
            340                 345                 350         


Arg Asp Glu Arg Thr Leu Ile Asn Pro Asp Ile Lys Val Val Asp Phe 
        355                 360                 365             


Gly Ser Ala Thr Tyr Asp Asp Glu His His Ser Thr Leu Val Ser Thr 
    370                 375                 380                 


Arg His Tyr Arg Ala Pro Glu Val Ile Leu Ala Leu Gly Trp Ser Gln 
385                 390                 395                 400 


Pro Cys Asp Val Trp Ser Ile Gly Cys Ile Leu Ile Glu Tyr Tyr Leu 
                405                 410                 415     


Gly Phe Thr Val Phe Pro Thr His Asp Ser Lys Glu His Leu Ala Met 
            420                 425                 430         


Met Glu Arg Ile Leu Gly Pro Leu Pro Lys His Met Ile Gln Lys Thr 
        435                 440                 445             


Arg Lys Arg Lys Tyr Phe His His Asp Arg Leu Asp Trp Asp Glu His 
    450                 455                 460                 


Ser Ser Ala Gly Arg Tyr Val Ser Arg Arg Cys Lys Pro Leu Lys Glu 
465                 470                 475                 480 


Phe Met Leu Ser Gln Asp Val Glu His Glu Arg Leu Phe Asp Leu Ile 
                485                 490                 495     


Gln Lys Met Leu Glu Tyr Asp Pro Ala Lys Arg Ile Thr Leu Arg Glu 
            500                 505                 510         


Ala Leu Lys His Pro Phe Phe Asp Leu Leu Lys Lys Ser Ile 
        515                 520                 525     


<210>  2286
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLK2__Homo_sapiens__NP_001281267

<400>  2286

Met Pro His Pro Arg Arg Tyr His Ser Ser Glu Arg Gly Ser Arg Gly 
1               5                   10                  15      


Ser Tyr Arg Glu His Tyr Arg Ser Arg Lys His Lys Arg Arg Arg Ser 
            20                  25                  30          


Arg Ser Trp Ser Ser Ser Ser Asp Arg Thr Arg Arg Arg Arg Arg Glu 
        35                  40                  45              


Asp Ser Tyr His Val Arg Ser Arg Ser Ser Tyr Asp Asp Arg Ser Ser 
    50                  55                  60                  


Asp Arg Arg Val Tyr Asp Arg Arg Tyr Cys Gly Ser Tyr Arg Arg Asn 
65                  70                  75                  80  


Asp Tyr Ser Arg Asp Arg Gly Asp Ala Tyr Tyr Asp Thr Asp Tyr Arg 
                85                  90                  95      


His Ser Tyr Glu Tyr Gln Arg Glu Asn Ser Ser Tyr Arg Ser Gln Arg 
            100                 105                 110         


Ser Ser Arg Arg Lys His Arg Arg Arg Arg Arg Arg Ser Arg Thr Phe 
        115                 120                 125             


Ser Arg Ser Ser Ser Gln His Ser Ser Arg Arg Ala Lys Ser Val Glu 
    130                 135                 140                 


Asp Asp Ala Glu Gly His Leu Ile Tyr His Val Gly Asp Trp Leu Gln 
145                 150                 155                 160 


Glu Arg Tyr Glu Ile Val Ser Thr Leu Gly Glu Gly Thr Phe Gly Arg 
                165                 170                 175     


Val Val Gln Cys Val Asp His Arg Arg Gly Gly Ala Arg Val Ala Leu 
            180                 185                 190         


Lys Ile Ile Lys Asn Val Glu Lys Tyr Lys Glu Ala Ala Arg Leu Glu 
        195                 200                 205             


Ile Asn Val Leu Glu Lys Ile Asn Glu Lys Asp Pro Asp Asn Lys Asn 
    210                 215                 220                 


Leu Cys Val Gln Met Phe Asp Trp Phe Asp Tyr His Gly His Met Cys 
225                 230                 235                 240 


Ile Ser Phe Glu Leu Leu Gly Leu Ser Thr Phe Asp Phe Leu Lys Asp 
                245                 250                 255     


Asn Asn Tyr Leu Pro Tyr Pro Ile His Gln Val Arg His Met Ala Phe 
            260                 265                 270         


Gln Leu Cys Gln Ala Val Lys Phe Leu His Asp Asn Lys Leu Thr His 
        275                 280                 285             


Thr Asp Leu Lys Pro Glu Asn Ile Leu Phe Val Asn Ser Asp Tyr Glu 
    290                 295                 300                 


Leu Thr Tyr Asn Leu Glu Lys Lys Arg Asp Glu Arg Ser Val Lys Ser 
305                 310                 315                 320 


Thr Ala Val Arg Val Val Asp Phe Gly Ser Ala Thr Phe Asp His Glu 
                325                 330                 335     


His His Ser Thr Ile Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val 
            340                 345                 350         


Ile Leu Glu Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly 
        355                 360                 365             


Cys Ile Ile Phe Glu Tyr Tyr Val Gly Phe Thr Leu Phe Gln Thr His 
    370                 375                 380                 


Asp Asn Arg Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Ile 
385                 390                 395                 400 


Pro Ser Arg Met Ile Arg Lys Thr Arg Lys Gln Lys Tyr Phe Tyr Arg 
                405                 410                 415     


Gly Arg Leu Asp Trp Asp Glu Asn Thr Ser Ala Gly Arg Tyr Val Arg 
            420                 425                 430         


Glu Asn Cys Lys Pro Leu Arg Arg Tyr Leu Thr Ser Glu Ala Glu Glu 
        435                 440                 445             


His His Gln Leu Phe Asp Leu Ile Glu Ser Met Leu Glu Tyr Glu Pro 
    450                 455                 460                 


Ala Lys Arg Leu Thr Leu Gly Glu Ala Leu Gln His Pro Phe Phe Ala 
465                 470                 475                 480 


Arg Leu Arg Ala Glu Pro Pro Asn Lys Leu Trp Asp Ser Ser Arg Asp 
                485                 490                 495     


Ile Ser Arg 
            


<210>  2287
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLLU1__Homo_sapiens__NP_001020404

<400>  2287

Met Phe Asn Lys Cys Ser Phe His Ser Ser Ile Tyr Arg Pro Ala Ala 
1               5                   10                  15      


Asp Asn Ser Ala Ser Ser Leu Cys Ala Ile Ile Cys Phe Leu Asn Leu 
            20                  25                  30          


Val Ile Glu Cys Asp Leu Glu Thr Asn Ser Glu Ile Asn Lys Leu Ile 
        35                  40                  45              


Ile Tyr Leu Phe Ser Gln Asn Asn Arg Ile Arg Phe Ser Lys Leu Leu 
    50                  55                  60                  


Leu Lys Ile Leu Phe Tyr Ile Ser Ile Phe Ser Tyr Pro Glu Leu Met 
65                  70                  75                  80  


Cys Glu Gln Tyr Val Thr Phe Ile Lys Pro Gly Ile His Tyr Gly Gln 
                85                  90                  95      


Val Ser Lys Lys His Ile Ile Tyr Ser Thr Phe Leu Ser Lys Asn Phe 
            100                 105                 110         


Lys Phe Gln Leu Leu Arg Val Cys Trp 
        115                 120     


<210>  2288
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLMN__Homo_sapiens__NP_079010

<400>  2288

Met Ala Ala His Glu Trp Asp Trp Phe Gln Arg Glu Glu Leu Ile Gly 
1               5                   10                  15      


Gln Ile Ser Asp Ile Arg Val Gln Asn Leu Gln Val Glu Arg Glu Asn 
            20                  25                  30          


Val Gln Lys Arg Thr Phe Thr Arg Trp Ile Asn Leu His Leu Glu Lys 
        35                  40                  45              


Cys Asn Pro Pro Leu Glu Val Lys Asp Leu Phe Val Asp Ile Gln Asp 
    50                  55                  60                  


Gly Lys Ile Leu Met Ala Leu Leu Glu Val Leu Ser Gly Arg Asn Leu 
65                  70                  75                  80  


Leu His Glu Tyr Lys Ser Ser Ser His Arg Ile Phe Arg Leu Asn Asn 
                85                  90                  95      


Ile Ala Lys Ala Leu Lys Phe Leu Glu Asp Ser Asn Val Lys Leu Val 
            100                 105                 110         


Ser Ile Asp Ala Ala Glu Ile Ala Asp Gly Asn Pro Ser Leu Val Leu 
        115                 120                 125             


Gly Leu Ile Trp Asn Ile Ile Leu Phe Phe Gln Ile Lys Glu Leu Thr 
    130                 135                 140                 


Gly Asn Leu Ser Arg Asn Ser Pro Ser Ser Ser Leu Ser Pro Gly Ser 
145                 150                 155                 160 


Gly Gly Thr Asp Ser Asp Ser Ser Phe Pro Pro Thr Pro Thr Ala Glu 
                165                 170                 175     


Arg Ser Val Ala Ile Ser Val Lys Asp Gln Arg Lys Ala Ile Lys Ala 
            180                 185                 190         


Leu Leu Ala Trp Val Gln Arg Lys Thr Arg Lys Tyr Gly Val Ala Val 
        195                 200                 205             


Gln Asp Phe Ala Gly Ser Trp Arg Ser Gly Leu Ala Phe Leu Ala Val 
    210                 215                 220                 


Ile Lys Ala Ile Asp Pro Ser Leu Val Asp Met Lys Gln Ala Leu Glu 
225                 230                 235                 240 


Asn Ser Thr Arg Glu Asn Leu Glu Lys Ala Phe Ser Ile Ala Gln Asp 
                245                 250                 255     


Ala Leu His Ile Pro Arg Leu Leu Glu Pro Glu Asp Ile Met Val Asp 
            260                 265                 270         


Thr Pro Asp Glu Gln Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Glu 
        275                 280                 285             


Arg Phe Pro Glu Leu Glu Ala Glu Asp Ile Phe Asp Ser Asp Lys Glu 
    290                 295                 300                 


Val Pro Ile Glu Ser Thr Phe Val Arg Ile Lys Glu Thr Pro Ser Glu 
305                 310                 315                 320 


Gln Glu Ser Lys Val Phe Val Leu Thr Glu Asn Gly Glu Arg Thr Tyr 
                325                 330                 335     


Thr Val Asn His Glu Thr Ser His Pro Pro Pro Ser Lys Val Phe Val 
            340                 345                 350         


Cys Asp Lys Pro Glu Ser Met Lys Glu Phe Arg Leu Asp Gly Val Ser 
        355                 360                 365             


Ser His Ala Leu Ser Asp Ser Ser Thr Glu Phe Met His Gln Ile Ile 
    370                 375                 380                 


Asp Gln Val Leu Gln Gly Gly Pro Gly Lys Thr Ser Asp Ile Ser Glu 
385                 390                 395                 400 


Pro Ser Pro Glu Ser Ser Ile Leu Ser Ser Arg Lys Glu Asn Gly Arg 
                405                 410                 415     


Ser Asn Ser Leu Pro Ile Lys Lys Thr Val His Phe Glu Ala Asp Thr 
            420                 425                 430         


Tyr Lys Asp Pro Phe Cys Ser Lys Asn Leu Ser Leu Cys Phe Glu Gly 
        435                 440                 445             


Ser Pro Arg Val Ala Lys Glu Ser Leu Arg Gln Asp Gly His Val Leu 
    450                 455                 460                 


Ala Val Glu Val Ala Glu Glu Lys Glu Gln Lys Gln Glu Ser Ser Lys 
465                 470                 475                 480 


Ile Pro Glu Ser Ser Ser Asp Lys Val Ala Gly Asp Ile Phe Leu Val 
                485                 490                 495     


Glu Gly Thr Asn Asn Asn Ser Gln Ser Ser Ser Cys Asn Gly Ala Leu 
            500                 505                 510         


Glu Ser Thr Ala Arg His Asp Glu Glu Ser His Ser Leu Ser Pro Pro 
        515                 520                 525             


Gly Glu Asn Thr Val Met Ala Asp Ser Phe Gln Ile Lys Val Asn Leu 
    530                 535                 540                 


Met Thr Val Glu Ala Leu Glu Glu Gly Asp Tyr Phe Glu Ala Ile Pro 
545                 550                 555                 560 


Leu Lys Ala Ser Lys Phe Asn Ser Asp Leu Ile Asp Phe Ala Ser Thr 
                565                 570                 575     


Ser Gln Ala Phe Asn Lys Val Pro Ser Pro His Glu Thr Lys Pro Asp 
            580                 585                 590         


Glu Asp Ala Glu Ala Phe Glu Asn His Ala Glu Lys Leu Gly Lys Arg 
        595                 600                 605             


Ser Ile Lys Ser Ala His Lys Lys Lys Asp Ser Pro Glu Pro Gln Val 
    610                 615                 620                 


Lys Met Asp Lys His Glu Pro His Gln Asp Ser Gly Glu Glu Ala Glu 
625                 630                 635                 640 


Gly Cys Pro Ser Ala Pro Glu Glu Thr Pro Val Asp Lys Lys Pro Glu 
                645                 650                 655     


Val His Glu Lys Ala Lys Arg Lys Ser Thr Arg Pro His Tyr Glu Glu 
            660                 665                 670         


Glu Gly Glu Asp Asp Asp Leu Gln Gly Val Gly Glu Glu Leu Ser Ser 
        675                 680                 685             


Ser Pro Pro Ser Ser Cys Val Ser Leu Glu Thr Leu Gly Ser His Ser 
    690                 695                 700                 


Glu Glu Gly Leu Asp Phe Lys Pro Ser Pro Pro Leu Ser Lys Val Ser 
705                 710                 715                 720 


Val Ile Pro His Asp Leu Phe Tyr Phe Pro His Tyr Glu Val Pro Leu 
                725                 730                 735     


Ala Ala Val Leu Glu Ala Tyr Val Glu Asp Pro Glu Asp Leu Lys Asn 
            740                 745                 750         


Glu Glu Met Asp Leu Glu Glu Pro Glu Gly Tyr Met Pro Asp Leu Asp 
        755                 760                 765             


Ser Arg Glu Glu Glu Ala Asp Gly Ser Gln Ser Ser Ser Ser Ser Ser 
    770                 775                 780                 


Val Pro Gly Glu Ser Leu Pro Ser Ala Ser Asp Gln Val Leu Tyr Leu 
785                 790                 795                 800 


Ser Arg Gly Gly Val Gly Thr Thr Pro Ala Ser Glu Pro Ala Pro Leu 
                805                 810                 815     


Ala Pro His Glu Asp His Gln Gln Arg Glu Thr Lys Glu Asn Asp Pro 
            820                 825                 830         


Met Asp Ser His Gln Ser Gln Glu Ser Pro Asn Leu Glu Asn Ile Ala 
        835                 840                 845             


Asn Pro Leu Glu Glu Asn Val Thr Lys Glu Ser Ile Ser Ser Lys Lys 
    850                 855                 860                 


Lys Glu Lys Arg Lys His Val Asp His Val Glu Ser Ser Leu Phe Val 
865                 870                 875                 880 


Ala Pro Gly Ser Val Gln Ser Ser Asp Asp Leu Glu Glu Asp Ser Ser 
                885                 890                 895     


Asp Tyr Ser Ile Pro Ser Arg Thr Ser His Ser Asp Ser Ser Ile Tyr 
            900                 905                 910         


Leu Arg Arg His Thr His Arg Ser Ser Glu Ser Asp His Phe Ser Tyr 
        915                 920                 925             


Val Gln Leu Arg Asn Ala Ala Asp Leu Asp Asp Arg Arg Asn Arg Ile 
    930                 935                 940                 


Leu Thr Arg Lys Ala Asn Ser Ser Gly Glu Ala Met Ser Leu Gly Ser 
945                 950                 955                 960 


His Ser Pro Gln Ser Asp Ser Leu Thr Gln Leu Val Gln Gln Pro Asp 
                965                 970                 975     


Met Met Tyr Phe Ile Leu Phe Leu Trp Leu Leu Val Tyr Cys Leu Leu 
            980                 985                 990         


Leu Phe Pro Gln Leu Asp Val Ser  Arg Leu 
        995                 1000         


<210>  2289
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLMP__Homo_sapiens__NP_079045

<400>  2289

Met Ser Leu Leu Leu Leu Leu Leu Leu Val Ser Tyr Tyr Val Gly Thr 
1               5                   10                  15      


Leu Gly Thr His Thr Glu Ile Lys Arg Val Ala Glu Glu Lys Val Thr 
            20                  25                  30          


Leu Pro Cys His His Gln Leu Gly Leu Pro Glu Lys Asp Thr Leu Asp 
        35                  40                  45              


Ile Glu Trp Leu Leu Thr Asp Asn Glu Gly Asn Gln Lys Val Val Ile 
    50                  55                  60                  


Thr Tyr Ser Ser Arg His Val Tyr Asn Asn Leu Thr Glu Glu Gln Lys 
65                  70                  75                  80  


Gly Arg Val Ala Phe Ala Ser Asn Phe Leu Ala Gly Asp Ala Ser Leu 
                85                  90                  95      


Gln Ile Glu Pro Leu Lys Pro Ser Asp Glu Gly Arg Tyr Thr Cys Lys 
            100                 105                 110         


Val Lys Asn Ser Gly Arg Tyr Val Trp Ser His Val Ile Leu Lys Val 
        115                 120                 125             


Leu Val Arg Pro Ser Lys Pro Lys Cys Glu Leu Glu Gly Glu Leu Thr 
    130                 135                 140                 


Glu Gly Ser Asp Leu Thr Leu Gln Cys Glu Ser Ser Ser Gly Thr Glu 
145                 150                 155                 160 


Pro Ile Val Tyr Tyr Trp Gln Arg Ile Arg Glu Lys Glu Gly Glu Asp 
                165                 170                 175     


Glu Arg Leu Pro Pro Lys Ser Arg Ile Asp Tyr Asn His Pro Gly Arg 
            180                 185                 190         


Val Leu Leu Gln Asn Leu Thr Met Ser Tyr Ser Gly Leu Tyr Gln Cys 
        195                 200                 205             


Thr Ala Gly Asn Glu Ala Gly Lys Glu Ser Cys Val Val Arg Val Thr 
    210                 215                 220                 


Val Gln Tyr Val Gln Ser Ile Gly Met Val Ala Gly Ala Val Thr Gly 
225                 230                 235                 240 


Ile Val Ala Gly Ala Leu Leu Ile Phe Leu Leu Val Trp Leu Leu Ile 
                245                 250                 255     


Arg Arg Lys Asp Lys Glu Arg Tyr Glu Glu Glu Glu Arg Pro Asn Glu 
            260                 265                 270         


Ile Arg Glu Asp Ala Glu Ala Pro Lys Ala Arg Leu Val Lys Pro Ser 
        275                 280                 285             


Ser Ser Ser Ser Gly Ser Arg Ser Ser Arg Ser Gly Ser Ser Ser Thr 
    290                 295                 300                 


Arg Ser Thr Ala Asn Ser Ala Ser Arg Ser Gln Arg Thr Leu Ser Thr 
305                 310                 315                 320 


Asp Ala Ala Pro Gln Pro Gly Leu Ala Thr Gln Ala Tyr Ser Leu Val 
                325                 330                 335     


Gly Pro Glu Val Arg Gly Ser Glu Pro Lys Lys Val His His Ala Asn 
            340                 345                 350         


Leu Thr Lys Ala Glu Thr Thr Pro Ser Met Ile Pro Ser Gln Ser Arg 
        355                 360                 365             


Ala Phe Gln Thr Val 
    370             


<210>  2290
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLN3__Homo_sapiens__NP_000077

<400>  2290

Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Thr Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Thr Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Thr 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Thr Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Thr Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Thr Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Thr Phe Leu Ser Leu Thr Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Thr Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Thr Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Thr Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Thr Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Thr 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Thr Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
    290                 295                 300                 


Leu Leu Phe Phe Trp Asn Thr Ser Leu Ser His Ala Gln Gln Tyr Arg 
305                 310                 315                 320 


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
                325                 330                 335     


Leu Arg Cys Cys Arg Ile Arg Phe Thr Trp Ala Leu Ala Leu Leu Gln 
            340                 345                 350         


Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu 
        355                 360                 365             


Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu 
    370                 375                 380                 


Gly Gly Ala Ala Tyr Val Asn Thr Phe His Asn Ile Ala Leu Glu Thr 
385                 390                 395                 400 


Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Thr Cys Ile Ser Asp 
                405                 410                 415     


Thr Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp 
            420                 425                 430         


Phe Leu Cys Gln Leu Ser 
        435             


<210>  2291
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLN5__Homo_sapiens__NP_006484

<400>  2291

Met Arg Arg Asn Leu Arg Leu Gly Pro Ser Ser Gly Ala Asp Ala Gln 
1               5                   10                  15      


Gly Gln Gly Ala Pro Arg Pro Gly Leu Ala Ala Pro Arg Met Leu Leu 
            20                  25                  30          


Pro Pro Ala Ser Gln Ala Ser Arg Gly Ser Gly Ser Thr Gly Cys Ser 
        35                  40                  45              


Leu Met Ala Gln Glu Val Asp Thr Ala Gln Gly Ala Glu Met Arg Arg 
    50                  55                  60                  


Gly Ala Gly Ala Ala Arg Gly Arg Ala Ser Trp Cys Trp Ala Leu Ala 
65                  70                  75                  80  


Leu Leu Trp Leu Ala Val Val Pro Gly Trp Ser Arg Val Ser Gly Ile 
                85                  90                  95      


Pro Ser Arg Arg His Trp Pro Val Pro Tyr Lys Arg Phe Asp Phe Arg 
            100                 105                 110         


Pro Lys Pro Asp Pro Tyr Cys Gln Ala Lys Tyr Thr Phe Cys Pro Thr 
        115                 120                 125             


Gly Ser Pro Ile Pro Val Met Glu Gly Asp Asp Asp Ile Glu Val Phe 
    130                 135                 140                 


Arg Leu Gln Ala Pro Val Trp Glu Phe Lys Tyr Gly Asp Leu Leu Gly 
145                 150                 155                 160 


His Leu Lys Ile Met His Asp Ala Ile Gly Phe Arg Ser Thr Leu Thr 
                165                 170                 175     


Gly Lys Asn Tyr Thr Met Glu Trp Tyr Glu Leu Phe Gln Leu Gly Asn 
            180                 185                 190         


Cys Thr Phe Pro His Leu Arg Pro Glu Met Asp Ala Pro Phe Trp Cys 
        195                 200                 205             


Asn Gln Gly Ala Ala Cys Phe Phe Glu Gly Ile Asp Asp Val His Trp 
    210                 215                 220                 


Lys Glu Asn Gly Thr Leu Val Gln Val Ala Thr Ile Ser Gly Asn Met 
225                 230                 235                 240 


Phe Asn Gln Met Ala Lys Trp Val Lys Gln Asp Asn Glu Thr Gly Ile 
                245                 250                 255     


Tyr Tyr Glu Thr Trp Asn Val Lys Ala Ser Pro Glu Lys Gly Ala Glu 
            260                 265                 270         


Thr Trp Phe Asp Ser Tyr Asp Cys Ser Lys Phe Val Leu Arg Thr Phe 
        275                 280                 285             


Asn Lys Leu Ala Glu Phe Gly Ala Glu Phe Lys Asn Ile Glu Thr Asn 
    290                 295                 300                 


Tyr Thr Arg Ile Phe Leu Tyr Ser Gly Glu Pro Thr Tyr Leu Gly Asn 
305                 310                 315                 320 


Glu Thr Ser Val Phe Gly Pro Thr Gly Asn Lys Thr Leu Gly Leu Ala 
                325                 330                 335     


Ile Lys Arg Phe Tyr Tyr Pro Phe Lys Pro His Leu Pro Thr Lys Glu 
            340                 345                 350         


Phe Leu Leu Ser Leu Leu Gln Ile Phe Asp Ala Val Ile Val His Lys 
        355                 360                 365             


Gln Phe Tyr Leu Phe Tyr Asn Phe Glu Tyr Trp Phe Leu Pro Met Lys 
    370                 375                 380                 


Phe Pro Phe Ile Lys Ile Thr Tyr Glu Glu Ile Pro Leu Pro Ile Arg 
385                 390                 395                 400 


Asn Lys Thr Leu Ser Gly Leu 
                405         


<210>  2292
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLN6__Homo_sapiens__NP_060352

<400>  2292

Met Glu Ala Thr Arg Arg Arg Gln His Leu Gly Ala Thr Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gln Leu Gly Ala Ser Phe Leu Gln Ala Arg His Gly Ser Val 
            20                  25                  30          


Ser Ala Asp Glu Ala Ala Arg Thr Ala Pro Phe His Leu Asp Leu Trp 
        35                  40                  45              


Phe Tyr Phe Thr Leu Gln Asn Trp Val Leu Asp Phe Gly Arg Pro Ile 
    50                  55                  60                  


Ala Met Leu Val Phe Pro Leu Glu Trp Phe Pro Leu Asn Lys Pro Ser 
65                  70                  75                  80  


Val Gly Asp Tyr Phe His Met Ala Tyr Asn Val Ile Thr Pro Phe Leu 
                85                  90                  95      


Leu Leu Lys Leu Ile Glu Arg Ser Pro Arg Thr Leu Pro Arg Ser Ile 
            100                 105                 110         


Thr Tyr Val Ser Ile Ile Ile Phe Ile Met Gly Ala Ser Ile His Leu 
        115                 120                 125             


Val Gly Asp Ser Val Asn His Arg Leu Leu Phe Ser Gly Tyr Gln His 
    130                 135                 140                 


His Leu Ser Val Arg Glu Asn Pro Ile Ile Lys Asn Leu Lys Pro Glu 
145                 150                 155                 160 


Thr Leu Ile Asp Ser Phe Glu Leu Leu Tyr Tyr Tyr Asp Glu Tyr Leu 
                165                 170                 175     


Gly His Cys Met Trp Tyr Ile Pro Phe Phe Leu Ile Leu Phe Met Tyr 
            180                 185                 190         


Phe Ser Gly Cys Phe Thr Ala Ser Lys Ala Glu Ser Leu Ile Pro Gly 
        195                 200                 205             


Pro Ala Leu Leu Leu Val Ala Pro Ser Gly Leu Tyr Tyr Trp Tyr Leu 
    210                 215                 220                 


Val Thr Glu Gly Gln Ile Phe Ile Leu Phe Ile Phe Thr Phe Phe Ala 
225                 230                 235                 240 


Met Leu Ala Leu Val Leu His Gln Lys Arg Lys Arg Leu Phe Leu Asp 
                245                 250                 255     


Ser Asn Gly Leu Phe Leu Phe Ser Ser Phe Ala Leu Thr Leu Leu Leu 
            260                 265                 270         


Val Ala Leu Trp Val Ala Trp Leu Trp Asn Asp Pro Val Leu Arg Lys 
        275                 280                 285             


Lys Tyr Pro Gly Val Ile Tyr Val Pro Glu Pro Trp Ala Phe Tyr Thr 
    290                 295                 300                 


Leu His Val Ser Ser Arg His 
305                 310     


<210>  2293
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLN8__Homo_sapiens__NP_061764

<400>  2293

Met Asn Pro Ala Ser Asp Gly Gly Thr Ser Glu Ser Ile Phe Asp Leu 
1               5                   10                  15      


Asp Tyr Ala Ser Trp Gly Ile Arg Ser Thr Leu Met Val Ala Gly Phe 
            20                  25                  30          


Val Phe Tyr Leu Gly Val Phe Val Val Cys His Gln Leu Ser Ser Ser 
        35                  40                  45              


Leu Asn Ala Thr Tyr Arg Ser Leu Val Ala Arg Glu Lys Val Phe Trp 
    50                  55                  60                  


Asp Leu Ala Ala Thr Arg Ala Val Phe Gly Val Gln Ser Thr Ala Ala 
65                  70                  75                  80  


Gly Leu Trp Ala Leu Leu Gly Asp Pro Val Leu His Ala Asp Lys Ala 
                85                  90                  95      


Arg Gly Gln Gln Asn Trp Cys Trp Phe His Ile Thr Thr Ala Thr Gly 
            100                 105                 110         


Phe Phe Cys Phe Glu Asn Val Ala Val His Leu Ser Asn Leu Ile Phe 
        115                 120                 125             


Arg Thr Phe Asp Leu Phe Leu Val Ile His His Leu Phe Ala Phe Leu 
    130                 135                 140                 


Gly Phe Leu Gly Cys Leu Val Asn Leu Gln Ala Gly His Tyr Leu Ala 
145                 150                 155                 160 


Met Thr Thr Leu Leu Leu Glu Met Ser Thr Pro Phe Thr Cys Val Ser 
                165                 170                 175     


Trp Met Leu Leu Lys Ala Gly Trp Ser Glu Ser Leu Phe Trp Lys Leu 
            180                 185                 190         


Asn Gln Trp Leu Met Ile His Met Phe His Cys Arg Met Val Leu Thr 
        195                 200                 205             


Tyr His Met Trp Trp Val Cys Phe Trp His Trp Asp Gly Leu Val Ser 
    210                 215                 220                 


Ser Leu Tyr Leu Pro His Leu Thr Leu Phe Leu Val Gly Leu Ala Leu 
225                 230                 235                 240 


Leu Thr Leu Ile Ile Asn Pro Tyr Trp Thr His Lys Lys Thr Gln Gln 
                245                 250                 255     


Leu Leu Asn Pro Val Asp Trp Asn Phe Ala Gln Pro Glu Ala Lys Ser 
            260                 265                 270         


Arg Pro Glu Gly Asn Gly Gln Leu Leu Arg Lys Lys Arg Pro 
        275                 280                 285     


<210>  2294
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLNK__Homo_sapiens__NP_443196

<400>  2294

Met Asn Arg Gln Gly Asn Arg Lys Thr Thr Lys Glu Gly Ser Asn Asp 
1               5                   10                  15      


Leu Lys Phe Gln Asn Phe Ser Leu Pro Lys Asn Arg Ser Trp Pro Arg 
            20                  25                  30          


Ile Asn Ser Ala Thr Gly Gln Tyr Gln Arg Met Asn Lys Pro Leu Leu 
        35                  40                  45              


Asp Trp Glu Arg Asn Phe Ala Ala Val Leu Asp Gly Ala Lys Gly His 
    50                  55                  60                  


Ser Asp Asp Asp Tyr Asp Asp Pro Glu Leu Arg Met Glu Glu Thr Trp 
65                  70                  75                  80  


Gln Ser Ile Lys Ile Leu Pro Ala Arg Pro Ile Lys Glu Ser Glu Tyr 
                85                  90                  95      


Ala Asp Thr His Tyr Phe Lys Val Ala Met Asp Thr Pro Leu Pro Leu 
            100                 105                 110         


Asp Thr Arg Thr Ser Ile Ser Ile Gly Gln Pro Thr Trp Asn Thr Gln 
        115                 120                 125             


Thr Arg Leu Glu Arg Val Asp Lys Pro Ile Ser Lys Asp Val Arg Ser 
    130                 135                 140                 


Gln Asn Ile Lys Gly Asp Ala Ser Val Arg Lys Asn Lys Ile Pro Leu 
145                 150                 155                 160 


Pro Pro Pro Arg Pro Leu Ile Thr Leu Pro Lys Lys Tyr Gln Pro Leu 
                165                 170                 175     


Pro Pro Glu Pro Glu Ser Ser Arg Pro Pro Leu Ser Gln Arg His Thr 
            180                 185                 190         


Phe Pro Glu Val Gln Arg Met Pro Ser Gln Ile Ser Leu Arg Asp Leu 
        195                 200                 205             


Ser Glu Val Leu Glu Ala Glu Lys Val Pro His Asn Gln Arg Lys Pro 
    210                 215                 220                 


Glu Ser Thr His Leu Leu Glu Asn Gln Asn Thr Gln Glu Ile Pro Leu 
225                 230                 235                 240 


Ala Ile Ser Ser Ser Ser Phe Thr Thr Ser Asn His Ser Val Gln Asn 
                245                 250                 255     


Arg Asp His Arg Gly Gly Met Gln Pro Cys Ser Pro Gln Arg Cys Gln 
            260                 265                 270         


Pro Pro Ala Ser Cys Ser Pro His Glu Asn Ile Leu Pro Tyr Lys Tyr 
        275                 280                 285             


Thr Ser Trp Arg Pro Pro Phe Pro Lys Arg Ser Asp Arg Lys Asp Val 
    290                 295                 300                 


Gln His Asn Glu Trp Tyr Ile Gly Glu Tyr Ser Arg Gln Ala Val Glu 
305                 310                 315                 320 


Glu Ala Phe Met Lys Glu Asn Lys Asp Gly Ser Phe Leu Val Arg Asp 
                325                 330                 335     


Cys Ser Thr Lys Ser Lys Glu Glu Pro Tyr Val Leu Ala Val Phe Tyr 
            340                 345                 350         


Glu Asn Lys Val Tyr Asn Val Lys Ile Arg Phe Leu Glu Arg Asn Gln 
        355                 360                 365             


Gln Phe Ala Leu Gly Thr Gly Leu Arg Gly Asp Glu Lys Phe Asp Ser 
    370                 375                 380                 


Val Glu Asp Ile Ile Glu His Tyr Lys Asn Phe Pro Ile Ile Leu Ile 
385                 390                 395                 400 


Asp Gly Lys Asp Lys Thr Gly Val His Arg Lys Gln Cys His Leu Thr 
                405                 410                 415     


Gln Pro Leu Pro Leu Thr Arg His Leu Leu Pro Leu 
            420                 425             


<210>  2295
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLNS1A__Homo_sapiens__NP_001284

<400>  2295

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Pro Ala Glu Gly Leu 
1               5                   10                  15      


Leu Arg Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
            20                  25                  30          


Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
        35                  40                  45              


Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
    50                  55                  60                  


Ala Leu Ser Arg Asp Arg Ser Asp Cys Leu Gly Glu His Leu Tyr Val 
65                  70                  75                  80  


Met Val Asn Ala Lys Phe Glu Glu Glu Ser Lys Glu Pro Val Ala Asp 
                85                  90                  95      


Glu Glu Glu Glu Asp Ser Asp Asp Asp Val Glu Pro Ile Thr Glu Phe 
            100                 105                 110         


Arg Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala 
        115                 120                 125             


Met Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser 
    130                 135                 140                 


Asp Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly 
145                 150                 155                 160 


Gln Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His 
                165                 170                 175     


Leu Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu 
            180                 185                 190         


Ser Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu 
        195                 200                 205             


Asp Ser Ile Arg Asp Tyr Glu Asp Gly Met Glu Val Asp Thr Thr Pro 
    210                 215                 220                 


Thr Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
225                 230                 235         


<210>  2296
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLOCK__Homo_sapiens__NP_004889

<400>  2296

Met Leu Phe Thr Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Thr Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Thr Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Thr Phe Leu Ser Asn Glu Glu Phe Thr Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Thr Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Thr Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Thr His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Thr Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Thr Ile Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Thr Tyr Glu Tyr Val Lys Phe Ile Gly Asn Phe Lys Ser Leu Asn Ser 
    210                 215                 220                 


Val Ser Ser Ser Ala His Asn Gly Phe Glu Gly Thr Ile Gln Arg Thr 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Thr Val Arg 
                245                 250                 255     


Leu Ala Thr Pro Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Glu Thr Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Thr Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Thr Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Thr Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Thr Pro Thr Lys Ile Pro Thr Asp Thr Ser Thr Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Val Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Ile Asn Ser Gln Ser Val Gly Ser Ser Leu Thr Gln 
                485                 490                 495     


Pro Val Met Ser Gln Ala Thr Asn Leu Pro Ile Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Thr Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Ser Asn Ile Gln Gln Leu 
            580                 585                 590         


Ala Pro Ile Asn Met Gln Gly Gln Val Val Pro Thr Asn Gln Ile Gln 
        595                 600                 605             


Ser Gly Met Asn Thr Gly His Ile Gly Thr Thr Gln His Met Ile Gln 
    610                 615                 620                 


Gln Gln Thr Leu Gln Ser Thr Ser Thr Gln Ser Gln Gln Asn Val Leu 
625                 630                 635                 640 


Ser Gly His Ser Gln Gln Thr Ser Leu Pro Ser Gln Thr Gln Ser Thr 
                645                 650                 655     


Leu Thr Ala Pro Leu Tyr Asn Thr Met Val Ile Ser Gln Pro Ala Ala 
            660                 665                 670         


Gly Ser Met Val Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Thr Gln 
        675                 680                 685             


Ser Ala Ala Val Thr Thr Phe Thr Gln Asp Arg Gln Ile Arg Phe Ser 
    690                 695                 700                 


Gln Gly Gln Gln Leu Val Thr Lys Leu Val Thr Ala Pro Val Ala Cys 
705                 710                 715                 720 


Gly Ala Val Met Val Pro Ser Thr Met Leu Met Gly Gln Val Val Thr 
                725                 730                 735     


Ala Tyr Pro Thr Phe Ala Thr Gln Gln Gln Gln Ser Gln Thr Leu Ser 
            740                 745                 750         


Val Thr Gln Gln Gln Gln Gln Gln Ser Ser Gln Glu Gln Gln Leu Thr 
        755                 760                 765             


Ser Val Gln Gln Pro Ser Gln Ala Gln Leu Thr Gln Pro Pro Gln Gln 
    770                 775                 780                 


Phe Leu Gln Thr Ser Arg Leu Leu His Gly Asn Pro Ser Thr Gln Leu 
785                 790                 795                 800 


Ile Leu Ser Ala Ala Phe Pro Leu Gln Gln Ser Thr Phe Pro Gln Ser 
                805                 810                 815     


His His Gln Gln His Gln Ser Gln Gln Gln Gln Gln Leu Ser Arg His 
            820                 825                 830         


Arg Thr Asp Ser Leu Pro Asp Pro Ser Lys Val Gln Pro Gln 
        835                 840                 845     


<210>  2297
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLP1__Homo_sapiens__NP_001136069

<400>  2297

Met Gly Glu Glu Ala Asn Asp Asp Lys Lys Pro Thr Thr Lys Phe Glu 
1               5                   10                  15      


Leu Glu Arg Glu Thr Glu Leu Arg Phe Glu Val Glu Ala Ser Gln Ser 
            20                  25                  30          


Val Gln Leu Glu Leu Leu Thr Gly Met Ala Glu Ile Phe Gly Thr Glu 
        35                  40                  45              


Leu Thr Arg Asn Lys Lys Phe Thr Phe Asp Ala Gly Ala Lys Val Ala 
    50                  55                  60                  


Val Phe Thr Trp His Gly Cys Ser Val Gln Leu Ser Gly Arg Thr Glu 
65                  70                  75                  80  


Val Ala Tyr Val Ser Lys Asp Thr Pro Met Leu Leu Tyr Leu Asn Thr 
                85                  90                  95      


His Thr Ala Leu Glu Gln Met Arg Arg Gln Ala Glu Lys Glu Glu Glu 
            100                 105                 110         


Arg Gly Pro Arg Val Met Val Val Gly Pro Thr Asp Val Gly Lys Ser 
        115                 120                 125             


Thr Val Cys Arg Leu Leu Leu Asn Tyr Ala Ile Thr Ser Arg Leu Ala 
    130                 135                 140                 


Asp Val Phe Asn Gln Arg Cys Glu Val Asn Arg Arg Ala Ser Val Ser 
145                 150                 155                 160 


Gly Cys Val Ile Asn Thr Cys Gly Trp Val Lys Gly Ser Gly Tyr Gln 
                165                 170                 175     


Ala Leu Val His Ala Ala Ser Ala Phe Glu Val Asp Val Val Val Val 
            180                 185                 190         


Leu Asp Gln Glu Arg Leu Tyr Asn Glu Leu Lys Arg Asp Leu Pro His 
        195                 200                 205             


Phe Val Arg Thr Val Leu Leu Pro Lys Ser Gly Gly Val Val Glu Arg 
    210                 215                 220                 


Ser Lys Asp Phe Arg Arg Glu Cys Arg Asp Glu Arg Ile Arg Glu Tyr 
225                 230                 235                 240 


Phe Tyr Gly Phe Arg Gly Cys Phe Tyr Pro His Ala Phe Asn Val Lys 
                245                 250                 255     


Phe Ser Asp Val Lys Ile Tyr Lys Val Gly Ala Pro Thr Ile Pro Asp 
            260                 265                 270         


Ser Cys Leu Pro Leu Gly Met Ser Gln Glu Asp Asn Gln Leu Lys Leu 
        275                 280                 285             


Val Pro Val Thr Pro Gly Arg Asp Met Val His His Leu Leu Ser Val 
    290                 295                 300                 


Ser Thr Ala Glu Gly Thr Glu Glu Asn Leu Ser Glu Thr Ser Val Ala 
305                 310                 315                 320 


Gly Phe Ile Val Val Thr Ser Val Asp Leu Glu His Gln Val Phe Thr 
                325                 330                 335     


Val Leu Ser Pro Ala Pro Arg Pro Leu Pro Lys Asn Phe Leu Leu Ile 
            340                 345                 350         


Met Asp Ile Arg Phe Met Asp Leu Lys 
        355                 360     


<210>  2298
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLPP__Homo_sapiens__NP_006003

<400>  2298

Met Trp Pro Gly Ile Leu Val Gly Gly Ala Arg Val Ala Ser Cys Arg 
1               5                   10                  15      


Tyr Pro Ala Leu Gly Pro Arg Leu Ala Ala His Phe Pro Ala Gln Arg 
            20                  25                  30          


Pro Pro Gln Arg Thr Leu Gln Asn Gly Leu Ala Leu Gln Arg Cys Leu 
        35                  40                  45              


His Ala Thr Ala Thr Arg Ala Leu Pro Leu Ile Pro Ile Val Val Glu 
    50                  55                  60                  


Gln Thr Gly Arg Gly Glu Arg Ala Tyr Asp Ile Tyr Ser Arg Leu Leu 
65                  70                  75                  80  


Arg Glu Arg Ile Val Cys Val Met Gly Pro Ile Asp Asp Ser Val Ala 
                85                  90                  95      


Ser Leu Val Ile Ala Gln Leu Leu Phe Leu Gln Ser Glu Ser Asn Lys 
            100                 105                 110         


Lys Pro Ile His Met Tyr Ile Asn Ser Pro Gly Gly Val Val Thr Ala 
        115                 120                 125             


Gly Leu Ala Ile Tyr Asp Thr Met Gln Tyr Ile Leu Asn Pro Ile Cys 
    130                 135                 140                 


Thr Trp Cys Val Gly Gln Ala Ala Ser Met Gly Ser Leu Leu Leu Ala 
145                 150                 155                 160 


Ala Gly Thr Pro Gly Met Arg His Ser Leu Pro Asn Ser Arg Ile Met 
                165                 170                 175     


Ile His Gln Pro Ser Gly Gly Ala Arg Gly Gln Ala Thr Asp Ile Ala 
            180                 185                 190         


Ile Gln Ala Glu Glu Ile Met Lys Leu Lys Lys Gln Leu Tyr Asn Ile 
        195                 200                 205             


Tyr Ala Lys His Thr Lys Gln Ser Leu Gln Val Ile Glu Ser Ala Met 
    210                 215                 220                 


Glu Arg Asp Arg Tyr Met Ser Pro Met Glu Ala Gln Glu Phe Gly Ile 
225                 230                 235                 240 


Leu Asp Lys Val Leu Val His Pro Pro Gln Asp Gly Glu Asp Glu Pro 
                245                 250                 255     


Thr Leu Val Gln Lys Glu Pro Val Glu Ala Ala Pro Ala Ala Glu Pro 
            260                 265                 270         


Val Pro Ala Ser Thr 
        275         


<210>  2299
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLPS__Homo_sapiens__NP_001239527

<400>  2299

Met Glu Lys Ile Leu Ile Leu Leu Leu Val Ala Leu Ser Val Ala Tyr 
1               5                   10                  15      


Ala Ala Pro Gly Pro Arg Gly Ile Ile Ile Asn Leu Thr Leu Tyr Gly 
            20                  25                  30          


Ile Tyr Tyr Lys Cys Pro Cys Glu Arg Gly Leu Thr Cys Glu Gly Asp 
        35                  40                  45              


Lys Thr Ile Val Gly Ser Ile Thr Asn Thr Asn Phe Gly Ile Cys His 
    50                  55                  60                  


Asp Ala Gly Arg Ser Lys Gln 
65                  70      


<210>  2300
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLPTM1__Homo_sapiens__NP_001269104

<400>  2300

Met Ser Arg Lys Ala His Ile Thr Glu Lys Val Thr Ser Asn Gly Ser 
1               5                   10                  15      


Ile Gly Arg Asp Pro Pro Ala Glu Thr Gln Pro Gln Asn Pro Pro Ala 
            20                  25                  30          


Gln Pro Ala Pro Asn Ala Trp Gln Val Ile Lys Gly Val Leu Phe Arg 
        35                  40                  45              


Ile Phe Ile Ile Trp Ala Ile Ser Ser Trp Phe Arg Arg Gly Pro Ala 
    50                  55                  60                  


Pro Gln Asp Gln Ala Gly Pro Gly Gly Ala Pro Arg Val Ala Ser Arg 
65                  70                  75                  80  


Asn Leu Phe Pro Lys Asp Thr Leu Met Asn Leu His Val Tyr Ile Ser 
                85                  90                  95      


Glu His Glu His Phe Thr Asp Phe Asn Ala Thr Ser Ala Leu Phe Trp 
            100                 105                 110         


Glu Gln His Asp Leu Val Tyr Gly Asp Trp Thr Ser Gly Glu Asn Ser 
        115                 120                 125             


Asp Gly Cys Tyr Glu His Phe Ala Glu Leu Asp Ile Pro Gln Ser Val 
    130                 135                 140                 


Gln Gln Asn Gly Ser Ile Tyr Ile His Val Tyr Phe Thr Lys Ser Gly 
145                 150                 155                 160 


Phe His Pro Asp Pro Arg Gln Lys Ala Leu Tyr Arg Arg Leu Ala Thr 
                165                 170                 175     


Val His Met Ser Arg Met Ile Asn Lys Tyr Lys Arg Arg Arg Phe Gln 
            180                 185                 190         


Lys Thr Lys Asn Leu Leu Thr Gly Glu Thr Glu Ala Asp Pro Glu Met 
        195                 200                 205             


Ile Lys Arg Ala Glu Asp Tyr Gly Pro Val Glu Val Ile Ser His Trp 
    210                 215                 220                 


His Pro Asn Ile Thr Ile Asn Ile Val Asp Asp His Thr Pro Trp Val 
225                 230                 235                 240 


Lys Gly Ser Val Pro Pro Pro Leu Asp Gln Tyr Val Lys Phe Asp Ala 
                245                 250                 255     


Val Ser Gly Asp Tyr Tyr Pro Ile Ile Tyr Phe Asn Asp Tyr Trp Asn 
            260                 265                 270         


Leu Gln Lys Asp Tyr Tyr Pro Ile Asn Glu Ser Leu Ala Ser Leu Pro 
        275                 280                 285             


Leu Arg Val Ser Phe Cys Pro Leu Ser Leu Trp Arg Trp Gln Leu Tyr 
    290                 295                 300                 


Ala Ala Gln Ser Thr Lys Ser Pro Trp Asn Phe Leu Gly Asp Glu Leu 
305                 310                 315                 320 


Tyr Glu Gln Ser Asp Glu Glu Gln Asp Ser Val Lys Val Ala Leu Leu 
                325                 330                 335     


Glu Thr Asn Pro Tyr Leu Leu Ala Leu Thr Ile Ile Val Ser Ile Val 
            340                 345                 350         


His Ser Val Phe Glu Phe Leu Ala Phe Lys Asn Asp Ile Gln Phe Trp 
        355                 360                 365             


Asn Ser Arg Gln Ser Leu Glu Gly Leu Ser Val Arg Ser Val Phe Phe 
    370                 375                 380                 


Gly Val Phe Gln Ser Phe Val Val Leu Leu Tyr Ile Leu Asp Asn Glu 
385                 390                 395                 400 


Thr Asn Phe Val Val Gln Val Ser Val Phe Ile Gly Val Leu Ile Asp 
                405                 410                 415     


Leu Trp Lys Ile Thr Lys Val Met Asp Val Arg Leu Asp Arg Glu His 
            420                 425                 430         


Arg Val Ala Gly Ile Phe Pro Arg Leu Ser Phe Lys Asp Lys Ser Thr 
        435                 440                 445             


Tyr Ile Glu Ser Ser Thr Lys Val Tyr Asp Asp Met Ala Phe Arg Tyr 
    450                 455                 460                 


Leu Ser Trp Ile Leu Phe Pro Leu Leu Gly Cys Tyr Ala Val Tyr Ser 
465                 470                 475                 480 


Leu Leu Tyr Leu Glu His Lys Gly Trp Tyr Ser Trp Val Leu Ser Met 
                485                 490                 495     


Leu Tyr Gly Phe Leu Leu Thr Phe Gly Phe Ile Thr Met Thr Pro Gln 
            500                 505                 510         


Leu Phe Ile Asn Tyr Lys Leu Lys Ser Val Ala His Leu Pro Trp Arg 
        515                 520                 525             


Met Leu Thr Tyr Lys Ala Leu Asn Thr Phe Ile Asp Asp Leu Phe Ala 
    530                 535                 540                 


Phe Val Ile Lys Met Pro Val Met Tyr Arg Ile Gly Cys Leu Arg Asp 
545                 550                 555                 560 


Asp Val Val Phe Phe Ile Tyr Leu Tyr Gln Arg Trp Ile Tyr Arg Val 
                565                 570                 575     


Asp Pro Thr Arg Val Asn Glu Phe Gly Met Ser Gly Glu Asp Pro Thr 
            580                 585                 590         


Ala Ala Ala Pro Val Ala Glu Val Pro Thr Ala Ala Gly Ala Leu Thr 
        595                 600                 605             


Pro Thr Pro Ala Pro Thr Thr Thr Thr Ala Thr Arg Glu Glu Ala Ser 
    610                 615                 620                 


Thr Ser Leu Pro Thr Lys Pro Thr Gln Gly Ala Ser Ser Ala Ser Glu 
625                 630                 635                 640 


Pro Gln Glu Ala Pro Pro Lys Pro Ala Glu Asp Lys Lys Lys Asp 
                645                 650                 655 


<210>  2301
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLPTM1L__Homo_sapiens__NP_110409

<400>  2301

Met Trp Ser Gly Arg Ser Ser Phe Thr Ser Leu Val Val Gly Val Phe 
1               5                   10                  15      


Val Val Tyr Val Val His Thr Cys Trp Val Met Tyr Gly Ile Val Tyr 
            20                  25                  30          


Thr Arg Pro Cys Ser Gly Asp Ala Asn Cys Ile Gln Pro Tyr Leu Ala 
        35                  40                  45              


Arg Arg Pro Lys Leu Gln Leu Ser Val Tyr Thr Thr Thr Arg Ser His 
    50                  55                  60                  


Leu Gly Ala Glu Asn Asn Ile Asp Leu Val Leu Asn Val Glu Asp Phe 
65                  70                  75                  80  


Asp Val Glu Ser Lys Phe Glu Arg Thr Val Asn Val Ser Val Pro Lys 
                85                  90                  95      


Lys Thr Arg Asn Asn Gly Thr Leu Tyr Ala Tyr Ile Phe Leu His His 
            100                 105                 110         


Ala Gly Val Leu Pro Trp His Asp Gly Lys Gln Val His Leu Val Ser 
        115                 120                 125             


Pro Leu Thr Thr Tyr Met Val Pro Lys Pro Glu Glu Ile Asn Leu Leu 
    130                 135                 140                 


Thr Gly Glu Ser Asp Thr Gln Gln Ile Glu Ala Glu Lys Lys Pro Thr 
145                 150                 155                 160 


Ser Ala Leu Asp Glu Pro Val Ser His Trp Arg Pro Arg Leu Ala Leu 
                165                 170                 175     


Asn Val Met Ala Asp Asn Phe Val Phe Asp Gly Ser Ser Leu Pro Ala 
            180                 185                 190         


Asp Val His Arg Tyr Met Lys Met Ile Gln Leu Gly Lys Thr Val His 
        195                 200                 205             


Tyr Leu Pro Ile Leu Phe Ile Asp Gln Leu Ser Asn Arg Val Lys Asp 
    210                 215                 220                 


Leu Met Val Ile Asn Arg Ser Thr Thr Glu Leu Pro Leu Thr Val Ser 
225                 230                 235                 240 


Tyr Asp Lys Val Ser Leu Gly Arg Leu Arg Phe Trp Ile His Met Gln 
                245                 250                 255     


Asp Ala Val Tyr Ser Leu Gln Gln Phe Gly Phe Ser Glu Lys Asp Ala 
            260                 265                 270         


Asp Glu Val Lys Gly Ile Phe Val Asp Thr Asn Leu Tyr Phe Leu Ala 
        275                 280                 285             


Leu Thr Phe Phe Val Ala Ala Phe His Leu Leu Phe Asp Phe Leu Ala 
    290                 295                 300                 


Phe Lys Asn Asp Ile Ser Phe Trp Lys Lys Lys Lys Ser Met Ile Gly 
305                 310                 315                 320 


Met Ser Thr Lys Ala Val Leu Trp Arg Cys Phe Ser Thr Val Val Ile 
                325                 330                 335     


Phe Leu Phe Leu Leu Asp Glu Gln Thr Ser Leu Leu Val Leu Val Pro 
            340                 345                 350         


Ala Gly Val Gly Ala Ala Ile Glu Leu Trp Lys Val Lys Lys Ala Leu 
        355                 360                 365             


Lys Met Thr Ile Phe Trp Arg Gly Leu Met Pro Glu Phe Gln Phe Gly 
    370                 375                 380                 


Thr Tyr Ser Glu Ser Glu Arg Lys Thr Glu Glu Tyr Asp Thr Gln Ala 
385                 390                 395                 400 


Met Lys Tyr Leu Ser Tyr Leu Leu Tyr Pro Leu Cys Val Gly Gly Ala 
                405                 410                 415     


Val Tyr Ser Leu Leu Asn Ile Lys Tyr Lys Ser Trp Tyr Ser Trp Leu 
            420                 425                 430         


Ile Asn Ser Phe Val Asn Gly Val Tyr Ala Phe Gly Phe Leu Phe Met 
        435                 440                 445             


Leu Pro Gln Leu Phe Val Asn Tyr Lys Leu Lys Ser Val Ala His Leu 
    450                 455                 460                 


Pro Trp Lys Ala Phe Thr Tyr Lys Ala Phe Asn Thr Phe Ile Asp Asp 
465                 470                 475                 480 


Val Phe Ala Phe Ile Ile Thr Met Pro Thr Ser His Arg Leu Ala Cys 
                485                 490                 495     


Phe Arg Asp Asp Val Val Phe Leu Val Tyr Leu Tyr Gln Arg Trp Leu 
            500                 505                 510         


Tyr Pro Val Asp Lys Arg Arg Val Asn Glu Phe Gly Glu Ser Tyr Glu 
        515                 520                 525             


Glu Lys Ala Thr Arg Ala Pro His Thr Asp 
    530                 535             


<210>  2302
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLRN1__Homo_sapiens__NP_001182723

<400>  2302

Met Pro Ser Gln Gln Lys Lys Ile Ile Phe Cys Met Ala Gly Val Phe 
1               5                   10                  15      


Ser Phe Ala Cys Ala Leu Gly Val Val Thr Ala Leu Gly Thr Pro Leu 
            20                  25                  30          


Trp Ile Lys Ala Thr Val Leu Cys Lys Thr Gly Ala Leu Leu Val Asn 
        35                  40                  45              


Ala Ser Gly Gln Glu Leu Asp Lys Phe Met Gly Glu Met Gln Tyr Gly 
    50                  55                  60                  


Leu Phe His Gly Glu Gly Val Arg Gln Cys Gly Leu Gly Ala Arg Pro 
65                  70                  75                  80  


Phe Arg Phe Ser Phe Phe Pro Asp Leu Leu Lys Ala Ile Pro Val Ser 
                85                  90                  95      


Ile His Val Asn Val Ile Leu Phe Ser Ala Ile Leu Ile Val Leu Thr 
            100                 105                 110         


Met Val Gly Thr Ala Phe Phe Met Tyr Asn Ala Phe Gly Lys Pro Phe 
        115                 120                 125             


Glu Thr Leu His Gly Pro Leu Gly Leu Tyr Leu Leu Ser Phe Ile Ser 
    130                 135                 140                 


Val Ala Leu Trp Leu Pro Ala Thr Arg His Gln Ala Gln Gly Ser Cys 
145                 150                 155                 160 


Gly Cys Leu Val Met Ile Leu Phe Ala Ser Glu Val Lys Ile His His 
                165                 170                 175     


Leu Ser Glu Lys Ile Ala Asn Tyr Lys Glu Gly Thr Tyr Val Tyr Lys 
            180                 185                 190         


Thr Gln Ser Glu Lys Tyr Thr Thr Ser Phe Trp Val Ile Phe Phe Cys 
        195                 200                 205             


Phe Phe Val His Phe Leu Asn Gly Leu Leu Ile Arg Leu Ala Gly Phe 
    210                 215                 220                 


Gln Phe Pro Phe Ala Lys Ser Lys Asp Ala Glu Thr Thr Asn Val Ala 
225                 230                 235                 240 


Ala Asp Leu Met Tyr 
                245 


<210>  2303
<211>  1332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLSPN__Homo_sapiens__XP_011540241

<400>  2303

Met Thr Gly Glu Val Gly Ser Glu Val His Leu Glu Ile Asn Asp Pro 
1               5                   10                  15      


Asn Val Ile Ser Gln Glu Glu Ala Asp Ser Pro Ser Asp Ser Gly Gln 
            20                  25                  30          


Gly Ser Tyr Glu Thr Ile Gly Pro Leu Ser Glu Gly Asp Ser Asp Glu 
        35                  40                  45              


Glu Ile Phe Val Ser Lys Lys Leu Lys Asn Arg Lys Val Leu Gln Asp 
    50                  55                  60                  


Ser Asp Ser Glu Thr Glu Asp Thr Asn Ala Ser Pro Glu Lys Thr Thr 
65                  70                  75                  80  


Tyr Asp Ser Ala Glu Glu Glu Asn Lys Glu Asn Leu Tyr Ala Gly Lys 
                85                  90                  95      


Asn Thr Lys Ile Lys Arg Ile Tyr Lys Thr Val Ala Asp Ser Asp Glu 
            100                 105                 110         


Ser Tyr Met Glu Lys Ser Leu Tyr Gln Glu Asn Leu Glu Ala Gln Val 
        115                 120                 125             


Lys Pro Cys Leu Glu Leu Ser Leu Gln Ser Gly Asn Ser Thr Asp Phe 
    130                 135                 140                 


Thr Thr Asp Arg Lys Ser Ser Lys Lys His Ile His Asp Lys Glu Gly 
145                 150                 155                 160 


Thr Ala Gly Lys Ala Lys Val Lys Ser Lys Arg Arg Leu Glu Lys Glu 
                165                 170                 175     


Glu Arg Lys Met Glu Lys Ile Arg Gln Leu Lys Lys Lys Glu Thr Lys 
            180                 185                 190         


Asn Gln Glu Asp Asp Val Glu Gln Pro Phe Asn Asp Ser Gly Cys Leu 
        195                 200                 205             


Leu Val Asp Lys Asp Leu Phe Glu Thr Gly Leu Glu Asp Glu Asn Asn 
    210                 215                 220                 


Ser Pro Leu Glu Asp Glu Glu Ser Leu Glu Ser Ile Arg Ala Ala Val 
225                 230                 235                 240 


Lys Asn Lys Val Lys Lys His Lys Lys Lys Glu Pro Ser Leu Glu Ser 
                245                 250                 255     


Gly Val His Ser Phe Glu Glu Gly Ser Glu Leu Ser Lys Gly Thr Thr 
            260                 265                 270         


Arg Lys Glu Arg Lys Ala Ala Arg Leu Ser Lys Glu Ala Leu Lys Gln 
        275                 280                 285             


Leu His Ser Glu Thr Gln Arg Leu Ile Arg Glu Ser Ala Leu Asn Leu 
    290                 295                 300                 


Pro Tyr His Met Pro Glu Asn Lys Thr Ile His Asp Phe Phe Lys Arg 
305                 310                 315                 320 


Lys Pro Arg Pro Thr Cys His Gly Asn Ala Met Ala Leu Leu Lys Ser 
                325                 330                 335     


Ser Lys Tyr Gln Ser Ser His His Lys Glu Ile Ile Asp Thr Ala Asn 
            340                 345                 350         


Thr Thr Glu Met Asn Ser Asp His His Ser Lys Gly Ser Glu Gln Thr 
        355                 360                 365             


Thr Gly Ala Glu Asn Glu Val Glu Thr Asn Ala Leu Pro Val Val Ser 
    370                 375                 380                 


Lys Glu Thr Gln Ile Ile Thr Gly Ser Asp Glu Ser Cys Arg Lys Asp 
385                 390                 395                 400 


Leu Val Lys Asn Glu Glu Leu Glu Ile Gln Glu Lys Gln Lys Gln Ser 
                405                 410                 415     


Asp Ile Arg Pro Ser Pro Gly Asp Ser Ser Val Leu Gln Gln Glu Ser 
            420                 425                 430         


Asn Phe Leu Gly Asn Asn His Ser Glu Glu Cys Gln Val Gly Gly Leu 
        435                 440                 445             


Val Ala Phe Glu Pro His Ala Leu Glu Gly Glu Gly Pro Gln Asn Pro 
    450                 455                 460                 


Glu Glu Thr Asp Glu Lys Val Glu Glu Pro Glu Gln Gln Asn Lys Ser 
465                 470                 475                 480 


Ser Ala Val Gly Pro Pro Glu Lys Val Arg Arg Phe Thr Leu Asp Arg 
                485                 490                 495     


Leu Lys Gln Leu Gly Val Asp Val Ser Ile Lys Pro Arg Leu Gly Ala 
            500                 505                 510         


Asp Glu Asp Ser Phe Val Ile Leu Glu Pro Glu Thr Asn Arg Glu Leu 
        515                 520                 525             


Glu Ala Leu Lys Gln Arg Phe Trp Lys His Ala Asn Pro Ala Ala Lys 
    530                 535                 540                 


Pro Arg Ala Gly Gln Thr Val Asn Val Asn Val Ile Val Lys Asp Met 
545                 550                 555                 560 


Gly Thr Asp Gly Lys Glu Glu Leu Lys Ala Asp Val Val Pro Val Thr 
                565                 570                 575     


Leu Ala Pro Lys Lys Leu Asp Gly Ala Ser His Thr Lys Pro Gly Glu 
            580                 585                 590         


Lys Leu Gln Val Leu Lys Ala Lys Leu Gln Glu Ala Met Lys Leu Arg 
        595                 600                 605             


Arg Phe Glu Glu Arg Gln Lys Arg Gln Ala Leu Phe Lys Leu Asp Asn 
    610                 615                 620                 


Glu Asp Gly Phe Glu Glu Glu Glu Glu Glu Glu Glu Glu Met Thr Asp 
625                 630                 635                 640 


Glu Ser Glu Glu Asp Gly Glu Glu Lys Val Glu Lys Glu Glu Lys Glu 
                645                 650                 655     


Glu Glu Leu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gly Asn Gln Glu Thr Ala Glu Phe Leu Leu Ser Ser Glu Glu Ile Glu 
        675                 680                 685             


Thr Lys Asp Glu Lys Glu Met Asp Lys Glu Asn Asn Asp Gly Ser Ser 
    690                 695                 700                 


Glu Ile Gly Lys Ala Val Gly Phe Leu Ser Val Pro Lys Ser Leu Ser 
705                 710                 715                 720 


Ser Asp Ser Thr Leu Leu Leu Phe Lys Asp Ser Ser Ser Lys Met Gly 
                725                 730                 735     


Tyr Phe Pro Thr Glu Glu Lys Ser Glu Thr Asp Glu Asn Ser Gly Lys 
            740                 745                 750         


Gln Pro Ser Lys Leu Asp Glu Asp Asp Ser Cys Ser Leu Leu Thr Lys 
        755                 760                 765             


Glu Ser Ser His Asn Ser Ser Phe Glu Leu Ile Gly Ser Thr Ile Pro 
    770                 775                 780                 


Ser Tyr Gln Pro Cys Asn Arg Gln Thr Gly Arg Gly Thr Ser Phe Phe 
785                 790                 795                 800 


Pro Thr Ala Gly Gly Phe Arg Ser Pro Ser Pro Gly Leu Phe Arg Ala 
                805                 810                 815     


Ser Leu Val Ser Ser Ala Ser Lys Ser Ser Gly Lys Leu Ser Glu Pro 
            820                 825                 830         


Ser Leu Pro Ile Glu Asp Ser Gln Asp Leu Tyr Asn Ala Ser Pro Glu 
        835                 840                 845             


Pro Lys Thr Leu Phe Leu Gly Ala Gly Asp Phe Gln Phe Cys Leu Glu 
    850                 855                 860                 


Asp Asp Thr Gln Ser Gln Leu Leu Asp Ala Asp Gly Phe Leu Asn Val 
865                 870                 875                 880 


Arg Asn His Arg Asn Gln Tyr Gln Ala Leu Lys Pro Arg Leu Pro Leu 
                885                 890                 895     


Ala Ser Met Asp Glu Asn Ala Met Asp Ala Asn Met Asp Glu Leu Leu 
            900                 905                 910         


Asp Leu Cys Thr Gly Lys Phe Thr Ser Gln Ala Glu Lys His Leu Pro 
        915                 920                 925             


Arg Lys Ser Asp Lys Lys Glu Asn Met Glu Glu Leu Leu Asn Leu Cys 
    930                 935                 940                 


Ser Gly Lys Phe Thr Ser Gln Asp Ala Ser Thr Pro Ala Ser Ser Glu 
945                 950                 955                 960 


Leu Asn Lys Gln Glu Lys Glu Ser Ser Met Gly Asp Pro Met Glu Glu 
                965                 970                 975     


Ala Leu Ala Leu Cys Ser Gly Ser Phe Pro Thr Asp Lys Glu Glu Glu 
            980                 985                 990         


Asp Glu Glu Glu Glu Phe Gly Asp  Phe Arg Leu Val Ser  Asn Asp Asn 
        995                 1000                 1005             


Glu Phe  Asp Ser Asp Glu Asp  Glu His Ser Asp Ser  Gly Asn Asp 
    1010                 1015                 1020             


Leu Ala  Leu Glu Asp His Glu  Asp Asp Asp Glu Glu  Glu Leu Leu 
    1025                 1030                 1035             


Lys Arg  Ser Glu Lys Leu Lys  Arg Gln Met Arg Leu  Arg Lys Tyr 
    1040                 1045                 1050             


Leu Glu  Asp Glu Ala Glu Val  Ser Gly Ser Asp Val  Gly Ser Glu 
    1055                 1060                 1065             


Asp Glu  Tyr Asp Gly Glu Glu  Ile Asp Glu Tyr Glu  Glu Asp Val 
    1070                 1075                 1080             


Ile Asp  Glu Val Leu Pro Ser  Asp Glu Glu Leu Gln  Ser Gln Ile 
    1085                 1090                 1095             


Lys Lys  Ile His Met Lys Thr  Met Leu Asp Asp Asp  Lys Arg Gln 
    1100                 1105                 1110             


Leu Arg  Leu Tyr Gln Glu Arg  Tyr Leu Ala Asp Gly  Asp Leu His 
    1115                 1120                 1125             


Ser Asp  Gly Pro Gly Arg Met  Arg Lys Phe Arg Trp  Lys Asn Ile 
    1130                 1135                 1140             


Asp Asp  Ala Ser Gln Met Asp  Leu Phe His Arg Asp  Ser Asp Asp 
    1145                 1150                 1155             


Asp Gln  Thr Glu Glu Gln Leu  Asp Glu Ser Glu Ala  Arg Trp Arg 
    1160                 1165                 1170             


Lys Glu  Arg Ile Glu Arg Glu  Gln Trp Leu Arg Asp  Met Ala Gln 
    1175                 1180                 1185             


Gln Gly  Lys Ile Thr Ala Glu  Glu Glu Glu Glu Ile  Gly Glu Asp 
    1190                 1195                 1200             


Ser Gln  Phe Met Ile Leu Ala  Lys Lys Val Thr Ala  Lys Ala Leu 
    1205                 1210                 1215             


Gln Lys  Asn Ala Ser Arg Pro  Met Val Ile Gln Glu  Ser Lys Ser 
    1220                 1225                 1230             


Leu Leu  Arg Asn Pro Phe Glu  Ala Ile Arg Pro Gly  Ser Ala Gln 
    1235                 1240                 1245             


Gln Val  Lys Thr Gly Ser Leu  Leu Asn Gln Pro Lys  Ala Val Leu 
    1250                 1255                 1260             


Gln Lys  Leu Ala Ala Leu Ser  Asp His Asn Pro Ser  Ala Pro Arg 
    1265                 1270                 1275             


Asn Ser  Arg Asn Phe Val Phe  His Thr Leu Ser Pro  Val Lys Ala 
    1280                 1285                 1290             


Glu Ala  Ala Lys Glu Ser Ser  Lys Ser Gln Lys Ile  Pro Glu Lys 
    1295                 1300                 1305             


Asp Ser  Asp Trp Leu Thr Trp  Ser Gly Ala Pro Ile  Pro Gly Phe 
    1310                 1315                 1320             


Phe Arg  Leu Ser Phe Asp Pro  His Gly 
    1325                 1330         


<210>  2304
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLSTN1__Homo_sapiens__NP_001289812

<400>  2304

Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn 
            20                  25                  30          


Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu 
        35                  40                  45              


Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys 
    50                  55                  60                  


Asp Ala Pro Leu Arg Phe Ala Glu Ser Phe Glu Val Thr Val Thr Lys 
65                  70                  75                  80  


Glu Gly Glu Ile Cys Gly Phe Lys Ile His Gly Gln Asn Val Pro Phe 
                85                  90                  95      


Asp Ala Val Val Val Asp Lys Ser Thr Gly Glu Gly Val Ile Arg Ser 
            100                 105                 110         


Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys Asp Tyr Ser Phe Thr Ile 
        115                 120                 125             


Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp Gly Thr Asn Val Lys Lys 
    130                 135                 140                 


Ser His Lys Ala Thr Val His Ile Gln Val Asn Asp Val Asn Glu Tyr 
145                 150                 155                 160 


Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys Ala Thr Val Ile Glu Gly 
                165                 170                 175     


Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu Ala Val Asp Ala Asp Cys 
            180                 185                 190         


Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr Glu Ile Ile Thr Pro Asp 
        195                 200                 205             


Val Pro Phe Thr Val Asp Lys Asp Gly Tyr Ile Lys Asn Thr Glu Lys 
    210                 215                 220                 


Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys Leu Thr Val Thr Ala Tyr 
225                 230                 235                 240 


Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp Val Leu Val Lys Ile Ser 
                245                 250                 255     


Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln Gly Trp Asn Asn Arg Ile 
            260                 265                 270         


Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala Val Phe Pro Asn Ile His 
        275                 280                 285             


Leu Glu Thr Cys Asp Glu Pro Val Ala Ser Val Gln Ala Thr Val Glu 
    290                 295                 300                 


Leu Glu Thr Ser His Ile Gly Lys Gly Cys Asp Arg Asp Thr Tyr Ser 
305                 310                 315                 320 


Glu Lys Ser Leu His Arg Leu Cys Gly Ala Ala Ala Gly Thr Ala Glu 
                325                 330                 335     


Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn Trp Thr Met Gly Leu Pro 
            340                 345                 350         


Thr Asp Asn Gly His Asp Ser Asp Gln Val Phe Glu Phe Asn Gly Thr 
        355                 360                 365             


Gln Ala Val Arg Ile Pro Asp Gly Val Val Ser Val Ser Pro Lys Glu 
    370                 375                 380                 


Pro Phe Thr Ile Ser Val Trp Met Arg His Gly Pro Phe Gly Arg Lys 
385                 390                 395                 400 


Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys Thr Asp Met Asn Arg His 
                405                 410                 415     


His Tyr Ser Leu Tyr Val His Gly Cys Arg Leu Ile Phe Leu Phe Arg 
            420                 425                 430         


Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg Pro Ala Glu Phe His Trp 
        435                 440                 445             


Lys Leu Asn Gln Val Cys Asp Glu Glu Trp His His Tyr Val Leu Asn 
    450                 455                 460                 


Val Glu Phe Pro Ser Val Thr Leu Tyr Val Asp Gly Thr Ser His Glu 
465                 470                 475                 480 


Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu His Pro Ser Lys Ile Glu 
                485                 490                 495     


Thr Gln Leu Val Val Gly Ala Cys Trp Gln Gly Gly Asp Leu His Met 
            500                 505                 510         


Thr Gln Phe Phe Arg Gly Asn Leu Ala Gly Leu Thr Leu Arg Ser Gly 
        515                 520                 525             


Lys Leu Ala Asp Lys Lys Val Ile Asp Cys Leu Tyr Thr Cys Lys Glu 
    530                 535                 540                 


Gly Leu Asp Leu Gln Val Leu Glu Asp Ser Gly Arg Gly Val Gln Ile 
545                 550                 555                 560 


Gln Ala His Pro Ser Gln Leu Val Leu Thr Leu Glu Gly Glu Asp Leu 
                565                 570                 575     


Gly Glu Leu Asp Lys Ala Met Gln His Ile Ser Tyr Leu Asn Ser Arg 
            580                 585                 590         


Gln Phe Pro Thr Pro Gly Ile Arg Arg Leu Lys Ile Thr Ser Thr Ile 
        595                 600                 605             


Lys Cys Phe Asn Glu Ala Thr Cys Ile Ser Val Pro Pro Val Asp Gly 
    610                 615                 620                 


Tyr Val Met Val Leu Gln Pro Glu Glu Pro Lys Ile Ser Leu Ser Gly 
625                 630                 635                 640 


Val His His Phe Ala Arg Ala Ala Ser Glu Phe Glu Ser Ser Glu Gly 
                645                 650                 655     


Val Phe Leu Phe Pro Glu Leu Arg Ile Ile Ser Thr Ile Thr Arg Glu 
            660                 665                 670         


Val Glu Pro Glu Gly Asp Gly Ala Glu Asp Pro Thr Val Gln Glu Ser 
        675                 680                 685             


Leu Val Ser Glu Glu Ile Val His Asp Leu Asp Thr Cys Glu Val Thr 
    690                 695                 700                 


Val Glu Gly Glu Glu Leu Asn His Glu Gln Glu Ser Leu Glu Val Asp 
705                 710                 715                 720 


Met Ala Arg Leu Gln Gln Lys Gly Ile Glu Val Ser Ser Ser Glu Leu 
                725                 730                 735     


Gly Met Thr Phe Thr Gly Val Asp Thr Met Ala Ser Tyr Glu Glu Val 
            740                 745                 750         


Leu His Leu Leu Arg Tyr Arg Asn Trp His Ala Arg Ser Leu Leu Asp 
        755                 760                 765             


Arg Lys Phe Lys Leu Ile Cys Ser Glu Leu Asn Gly Arg Tyr Ile Ser 
    770                 775                 780                 


Asn Glu Phe Lys Val Glu Val Asn Val Ile His Thr Ala Asn Pro Met 
785                 790                 795                 800 


Glu His Ala Asn His Met Ala Ala Gln Pro Gln Phe Val His Pro Glu 
                805                 810                 815     


His Arg Ser Phe Val Asp Leu Ser Gly His Asn Leu Ala Asn Pro His 
            820                 825                 830         


Pro Phe Ala Val Val Pro Ser Thr Ala Thr Val Val Ile Val Val Cys 
        835                 840                 845             


Val Ser Phe Leu Val Phe Met Ile Ile Leu Gly Val Phe Arg Ile Arg 
    850                 855                 860                 


Ala Ala His Arg Arg Thr Met Arg Asp Gln Asp Thr Gly Lys Glu Asn 
865                 870                 875                 880 


Glu Met Asp Trp Asp Asp Ser Ala Leu Thr Ile Thr Val Asn Pro Met 
                885                 890                 895     


Glu Thr Tyr Glu Asp Gln His Ser Ser Glu Glu Glu Glu Glu Glu Glu 
            900                 905                 910         


Glu Glu Glu Glu Ser Glu Asp Gly Glu Glu Glu Asp Asp Ile Thr Ser 
        915                 920                 925             


Ala Glu Ser Glu Ser Ser Glu Glu Glu Glu Gly Glu Gln Gly Asp Pro 
    930                 935                 940                 


Gln Asn Ala Thr Arg Gln Gln Gln Leu Glu Trp Asp Asp Ser Thr Leu 
945                 950                 955                 960 


Ser Tyr 
        


<210>  2305
<211>  955
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLSTN2__Homo_sapiens__NP_071414

<400>  2305

Met Leu Pro Gly Arg Leu Cys Trp Val Pro Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Gly Ser Gly Ser Gly Gly Gly Gly Asp Ser Arg Gln Arg Arg Leu 
            20                  25                  30          


Leu Ala Ala Lys Val Asn Lys His Lys Pro Trp Ile Glu Thr Ser Tyr 
        35                  40                  45              


His Gly Val Ile Thr Glu Asn Asn Asp Thr Val Ile Leu Asp Pro Pro 
    50                  55                  60                  


Leu Val Ala Leu Asp Lys Asp Ala Pro Val Pro Phe Ala Gly Glu Ile 
65                  70                  75                  80  


Cys Ala Phe Lys Ile His Gly Gln Glu Leu Pro Phe Glu Ala Val Val 
                85                  90                  95      


Leu Asn Lys Thr Ser Gly Glu Gly Arg Leu Arg Ala Lys Ser Pro Ile 
            100                 105                 110         


Asp Cys Glu Leu Gln Lys Glu Tyr Thr Phe Ile Ile Gln Ala Tyr Asp 
        115                 120                 125             


Cys Gly Ala Gly Pro His Glu Thr Ala Trp Lys Lys Ser His Lys Ala 
    130                 135                 140                 


Val Val His Ile Gln Val Lys Asp Val Asn Glu Phe Ala Pro Thr Phe 
145                 150                 155                 160 


Lys Glu Pro Ala Tyr Lys Ala Val Val Thr Glu Gly Lys Ile Tyr Asp 
                165                 170                 175     


Ser Ile Leu Gln Val Glu Ala Ile Asp Glu Asp Cys Ser Pro Gln Tyr 
            180                 185                 190         


Ser Gln Ile Cys Asn Tyr Glu Ile Val Thr Thr Asp Val Pro Phe Ala 
        195                 200                 205             


Ile Asp Arg Asn Gly Asn Ile Arg Asn Thr Glu Lys Leu Ser Tyr Asp 
    210                 215                 220                 


Lys Gln His Gln Tyr Glu Ile Leu Val Thr Ala Tyr Asp Cys Gly Gln 
225                 230                 235                 240 


Lys Pro Ala Ala Gln Asp Thr Leu Val Gln Val Asp Val Lys Pro Val 
                245                 250                 255     


Cys Lys Pro Gly Trp Gln Asp Trp Thr Lys Arg Ile Glu Tyr Gln Pro 
            260                 265                 270         


Gly Ser Gly Ser Met Pro Leu Phe Pro Ser Ile His Leu Glu Thr Cys 
        275                 280                 285             


Asp Gly Ala Val Ser Ser Leu Gln Ile Val Thr Glu Leu Gln Thr Asn 
    290                 295                 300                 


Tyr Ile Gly Lys Gly Cys Asp Arg Glu Thr Tyr Ser Glu Lys Ser Leu 
305                 310                 315                 320 


Gln Lys Leu Cys Gly Ala Ser Ser Gly Ile Ile Asp Leu Leu Pro Ser 
                325                 330                 335     


Pro Ser Ala Ala Thr Asn Trp Thr Ala Gly Leu Leu Val Asp Ser Ser 
            340                 345                 350         


Glu Met Ile Phe Lys Phe Asp Gly Arg Gln Gly Ala Lys Val Pro Asp 
        355                 360                 365             


Gly Ile Val Pro Lys Asn Leu Thr Asp Gln Phe Thr Ile Thr Met Trp 
    370                 375                 380                 


Met Lys His Gly Pro Ser Pro Gly Val Arg Ala Glu Lys Glu Thr Ile 
385                 390                 395                 400 


Leu Cys Asn Ser Asp Lys Thr Glu Met Asn Arg His His Tyr Ala Leu 
                405                 410                 415     


Tyr Val His Asn Cys Arg Leu Val Phe Leu Leu Arg Lys Asp Phe Asp 
            420                 425                 430         


Gln Ala Asp Thr Phe Arg Pro Ala Glu Phe His Trp Lys Leu Asp Gln 
        435                 440                 445             


Ile Cys Asp Lys Glu Trp His Tyr Tyr Val Ile Asn Val Glu Phe Pro 
    450                 455                 460                 


Val Val Thr Leu Tyr Met Asp Gly Ala Thr Tyr Glu Pro Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Asp Trp Pro Ile His Pro Ser His Ile Ala Met Gln Leu Thr 
                485                 490                 495     


Val Gly Ala Cys Trp Gln Gly Gly Glu Val Thr Lys Pro Gln Phe Ala 
            500                 505                 510         


Gln Phe Phe His Gly Ser Leu Ala Ser Leu Thr Ile Arg Pro Gly Lys 
        515                 520                 525             


Met Glu Ser Gln Lys Val Ile Ser Cys Leu Gln Ala Cys Lys Glu Gly 
    530                 535                 540                 


Leu Asp Ile Asn Ser Leu Glu Ser Leu Gly Gln Gly Ile Lys Tyr His 
545                 550                 555                 560 


Phe Asn Pro Ser Gln Ser Ile Leu Val Met Glu Gly Asp Asp Ile Gly 
                565                 570                 575     


Asn Ile Asn Arg Ala Leu Gln Lys Val Ser Tyr Ile Asn Ser Arg Gln 
            580                 585                 590         


Phe Pro Thr Ala Gly Val Arg Arg Leu Lys Val Ser Ser Lys Val Gln 
        595                 600                 605             


Cys Phe Gly Glu Asp Val Cys Ile Ser Ile Pro Glu Val Asp Ala Tyr 
    610                 615                 620                 


Val Met Val Leu Gln Ala Ile Glu Pro Arg Ile Thr Leu Arg Gly Thr 
625                 630                 635                 640 


Asp His Phe Trp Arg Pro Ala Ala Gln Phe Glu Ser Ala Arg Gly Val 
                645                 650                 655     


Thr Leu Phe Pro Asp Ile Lys Ile Val Ser Thr Phe Ala Lys Thr Glu 
            660                 665                 670         


Ala Pro Gly Asp Val Lys Thr Thr Asp Pro Lys Ser Glu Val Leu Glu 
        675                 680                 685             


Glu Met Leu His Asn Leu Asp Phe Cys Asp Ile Leu Val Ile Gly Gly 
    690                 695                 700                 


Asp Leu Asp Pro Arg Gln Glu Cys Leu Glu Leu Asn His Ser Glu Leu 
705                 710                 715                 720 


His Gln Arg His Leu Asp Ala Thr Asn Ser Thr Ala Gly Tyr Ser Ile 
                725                 730                 735     


Tyr Gly Val Gly Ser Met Ser Arg Tyr Glu Gln Val Leu His His Ile 
            740                 745                 750         


Arg Tyr Arg Asn Trp Arg Pro Ala Ser Leu Glu Ala Arg Arg Phe Arg 
        755                 760                 765             


Ile Lys Cys Ser Glu Leu Asn Gly Arg Tyr Thr Ser Asn Glu Phe Asn 
    770                 775                 780                 


Leu Glu Val Ser Ile Leu His Glu Asp Gln Val Ser Asp Lys Glu His 
785                 790                 795                 800 


Val Asn His Leu Ile Val Gln Pro Pro Phe Leu Gln Ser Val His His 
                805                 810                 815     


Pro Glu Ser Arg Ser Ser Ile Gln His Ser Ser Val Val Pro Ser Ile 
            820                 825                 830         


Ala Thr Val Val Ile Ile Ile Ser Val Cys Met Leu Val Phe Val Val 
        835                 840                 845             


Ala Met Gly Val Tyr Arg Val Arg Ile Ala His Gln His Phe Ile Gln 
    850                 855                 860                 


Glu Thr Glu Ala Ala Lys Glu Ser Glu Met Asp Trp Asp Asp Ser Ala 
865                 870                 875                 880 


Leu Thr Ile Thr Val Asn Pro Met Glu Lys His Glu Gly Pro Gly His 
                885                 890                 895     


Gly Glu Asp Glu Thr Glu Gly Glu Glu Glu Glu Glu Ala Glu Glu Glu 
            900                 905                 910         


Met Ser Ser Ser Ser Gly Ser Asp Asp Ser Glu Glu Glu Glu Glu Glu 
        915                 920                 925             


Glu Gly Met Gly Arg Gly Arg His Gly Gln Asn Gly Ala Arg Gln Ala 
    930                 935                 940                 


Gln Leu Glu Trp Asp Asp Ser Thr Leu Pro Tyr 
945                 950                 955 


<210>  2306
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLTA__Homo_sapiens__NP_001070145

<400>  2306

Met Ala Glu Leu Asp Pro Phe Gly Ala Pro Ala Gly Ala Pro Gly Gly 
1               5                   10                  15      


Pro Ala Leu Gly Asn Gly Val Ala Gly Ala Gly Glu Glu Asp Pro Ala 
            20                  25                  30          


Ala Ala Phe Leu Ala Gln Gln Glu Ser Glu Ile Ala Gly Ile Glu Asn 
        35                  40                  45              


Asp Glu Ala Phe Ala Ile Leu Asp Gly Gly Ala Pro Gly Pro Gln Pro 
    50                  55                  60                  


His Gly Glu Pro Pro Gly Gly Pro Asp Ala Val Asp Gly Val Met Asn 
65                  70                  75                  80  


Gly Glu Tyr Tyr Gln Glu Ser Asn Gly Pro Thr Asp Ser Tyr Ala Ala 
                85                  90                  95      


Ile Ser Gln Val Asp Arg Leu Gln Ser Glu Pro Glu Ser Ile Arg Lys 
            100                 105                 110         


Trp Arg Glu Glu Gln Met Glu Arg Leu Glu Ala Leu Asp Ala Asn Ser 
        115                 120                 125             


Arg Lys Gln Glu Ala Glu Trp Lys Glu Lys Ala Ile Lys Glu Leu Glu 
    130                 135                 140                 


Glu Trp Tyr Ala Arg Gln Asp Glu Gln Leu Gln Lys Thr Lys Ala Asn 
145                 150                 155                 160 


Asn Arg Val Ala Asp Glu Ala Phe Tyr Lys Gln Pro Phe Ala Asp Val 
                165                 170                 175     


Ile Gly Tyr Val Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Glu 
            180                 185                 190         


Ser Ser Pro Gly Thr Glu Trp Glu Arg Val Ala Arg Leu Cys Asp Phe 
        195                 200                 205             


Asn Pro Lys Ser Ser Lys Gln Ala Lys Asp Val Ser Arg Met Arg Ser 
    210                 215                 220                 


Val Leu Ile Ser Leu Lys Gln Ala Pro Leu Val His 
225                 230                 235     


<210>  2307
<211>  1675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLTC__Homo_sapiens__NP_004850

<400>  2307

Met Ala Gln Ile Leu Pro Ile Arg Phe Gln Glu His Leu Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Val Ile Ile Asp Met Asn Asp Pro Ser Asn Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Asp Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Thr Asp Asp Val Thr Phe Trp Lys 
            100                 105                 110         


Trp Ile Ser Leu Asn Thr Val Ala Leu Val Thr Asp Asn Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Glu Ser Gln Pro Val Lys Met Phe Asp Arg 
    130                 135                 140                 


His Ser Ser Leu Ala Gly Cys Gln Ile Ile Asn Tyr Arg Thr Asp Ala 
145                 150                 155                 160 


Lys Gln Lys Trp Leu Leu Leu Thr Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ser Phe Ala Gln Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Glu Glu Ser Thr Leu Phe Cys Phe Ala Val Arg Gly Gln Ala 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Thr Pro Pro Thr Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Pro Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Ser Glu Lys His Asp Val 
            260                 265                 270         


Val Phe Leu Ile Thr Lys Tyr Gly Tyr Ile His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Thr Gly Thr Cys Ile Tyr Met Asn Arg Ile Ser Gly Glu Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Glu Ala Thr Ala Gly Ile Ile Gly Val Asn Arg 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Glu Asn Ile Ile Pro 
                325                 330                 335     


Tyr Ile Thr Asn Val Leu Gln Asn Pro Asp Leu Ala Leu Arg Met Ala 
            340                 345                 350         


Val Arg Asn Asn Leu Ala Gly Ala Glu Glu Leu Phe Ala Arg Lys Phe 
        355                 360                 365             


Asn Ala Leu Phe Ala Gln Gly Asn Tyr Ser Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Asn Ala Pro Lys Gly Ile Leu Arg Thr Pro Asp Thr Ile Arg Arg 
385                 390                 395                 400 


Phe Gln Ser Val Pro Ala Gln Pro Gly Gln Thr Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Tyr Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys Arg Pro Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Ser Val Asp Pro Thr Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Asn Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Val Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Asn Val Met Arg Ile Ser Pro Asp Gln 
        515                 520                 525             


Gly Gln Gln Phe Ala Gln Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asp Ile Thr Gln Ile Val Asp Val Phe Met Glu Tyr Asn Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ala Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ser 
                565                 570                 575     


Glu Gly Pro Leu Gln Thr Arg Leu Leu Glu Met Asn Leu Met His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Gln Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Arg Ala Leu Glu His Phe Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Tyr Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Leu Glu Cys Leu Arg Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Ile Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Ser Thr Gln Ser Leu Ile Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Phe Glu Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Phe Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Asn 
            740                 745                 750         


Cys Tyr Asp Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Asp Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Lys Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Leu Pro Val Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Asp Val Ile Lys Asn Leu 
            820                 825                 830         


Ile Leu Val Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ala 
    850                 855                 860                 


Arg Ile His Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Asn Pro Glu Arg Phe Leu Arg Glu 
                885                 890                 895     


Asn Pro Tyr Tyr Asp Ser Arg Val Val Gly Lys Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Asn Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Leu Ser 
    930                 935                 940                 


Arg Tyr Leu Val Arg Arg Lys Asp Pro Glu Leu Trp Gly Ser Val Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Pro Tyr Arg Arg Pro Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Gln Asp Pro Glu Glu Val Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Asn  Arg Leu Asp Asn Tyr  Asp Ala Pro 
    1040                 1045                 1050             


Asp Ile  Ala Asn Ile Ala Ile  Ser Asn Glu Leu Phe  Glu Glu Ala 
    1055                 1060                 1065             


Phe Ala  Ile Phe Arg Lys Phe  Asp Val Asn Thr Ser  Ala Val Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Lys 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Gly Met  Val Lys Glu Ala Ile  Asp Ser Tyr 
    1115                 1120                 1125             


Ile Lys  Ala Asp Asp Pro Ser  Ser Tyr Met Glu Val  Val Gln Ala 
    1130                 1135                 1140             


Ala Asn  Thr Ser Gly Asn Trp  Glu Glu Leu Val Lys  Tyr Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Ala Arg  Glu Ser Tyr Val Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Asn Arg Leu Ala Glu  Leu Glu Glu 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Asp Glu Lys Met  Tyr Asp Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Asn Asn  Val Ser Asn Phe Gly  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Gly Ala Arg  Lys Ala Asn 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Val Asp Gly 
    1250                 1255                 1260             


Lys Glu  Phe Arg Leu Ala Gln  Met Cys Gly Leu His  Ile Val Val 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Ile Asn Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Thr Met Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Arg Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Ile  Ile Thr Met Met Asn  His Pro Thr 
    1370                 1375                 1380             


Asp Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Tyr Tyr  Arg Ala Ile Gln Phe  Tyr Leu Glu 
    1400                 1405                 1410             


Phe Lys  Pro Leu Leu Leu Asn  Asp Leu Leu Met Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Arg Ala  Val Asn Tyr Phe Ser  Lys Val Lys 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Asn His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ser Leu Asn Asn Leu  Phe Ile Thr 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Ala Leu  Arg Thr Ser Ile Asp  Ala Tyr Asp 
    1475                 1480                 1485             


Asn Phe  Asp Asn Ile Ser Leu  Ala Gln Arg Leu Glu  Lys His Glu 
    1490                 1495                 1500             


Leu Ile  Glu Phe Arg Arg Ile  Ala Ala Tyr Leu Phe  Lys Gly Asn 
    1505                 1510                 1515             


Asn Arg  Trp Lys Gln Ser Val  Glu Leu Cys Lys Lys  Asp Ser Leu 
    1520                 1525                 1530             


Tyr Lys  Asp Ala Met Gln Tyr  Ala Ser Glu Ser Lys  Asp Thr Glu 
    1535                 1540                 1545             


Leu Ala  Glu Glu Leu Leu Gln  Trp Phe Leu Gln Glu  Glu Lys Arg 
    1550                 1555                 1560             


Glu Cys  Phe Gly Ala Cys Leu  Phe Thr Cys Tyr Asp  Leu Leu Arg 
    1565                 1570                 1575             


Pro Asp  Val Val Leu Glu Thr  Ala Trp Arg His Asn  Ile Met Asp 
    1580                 1585                 1590             


Phe Ala  Met Pro Tyr Phe Ile  Gln Val Met Lys Glu  Tyr Leu Thr 
    1595                 1600                 1605             


Lys Val  Asp Lys Leu Asp Ala  Ser Glu Ser Leu Arg  Lys Glu Glu 
    1610                 1615                 1620             


Glu Gln  Ala Thr Glu Thr Gln  Pro Ile Val Tyr Gly  Gln Pro Gln 
    1625                 1630                 1635             


Leu Met  Leu Thr Ala Gly Pro  Ser Val Ala Val Pro  Pro Gln Ala 
    1640                 1645                 1650             


Pro Phe  Gly Tyr Gly Tyr Thr  Ala Pro Pro Tyr Gly  Gln Pro Gln 
    1655                 1660                 1665             


Pro Gly  Phe Gly Tyr Ser Met  
    1670                 1675 


<210>  2308
<211>  1583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLTCL1__Homo_sapiens__NP_001826

<400>  2308

Met Ala Gln Ile Leu Pro Val Arg Phe Gln Glu His Phe Gln Leu Gln 
1               5                   10                  15      


Asn Leu Gly Ile Asn Pro Ala Asn Ile Gly Phe Ser Thr Leu Thr Met 
            20                  25                  30          


Glu Ser Asp Lys Phe Ile Cys Ile Arg Glu Lys Val Gly Glu Gln Ala 
        35                  40                  45              


Gln Val Thr Ile Ile Asp Met Ser Asp Pro Met Ala Pro Ile Arg Arg 
    50                  55                  60                  


Pro Ile Ser Ala Glu Ser Ala Ile Met Asn Pro Ala Ser Lys Val Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Gly Lys Thr Leu Gln Ile Phe Asn Ile Glu Met Lys 
                85                  90                  95      


Ser Lys Met Lys Ala His Thr Met Ala Glu Glu Val Ile Phe Trp Lys 
            100                 105                 110         


Trp Val Ser Val Asn Thr Val Ala Leu Val Thr Glu Thr Ala Val Tyr 
        115                 120                 125             


His Trp Ser Met Glu Gly Asp Ser Gln Pro Met Lys Met Phe Asp Arg 
    130                 135                 140                 


His Thr Ser Leu Val Gly Cys Gln Val Ile His Tyr Arg Thr Asp Glu 
145                 150                 155                 160 


Tyr Gln Lys Trp Leu Leu Leu Val Gly Ile Ser Ala Gln Gln Asn Arg 
                165                 170                 175     


Val Val Gly Ala Met Gln Leu Tyr Ser Val Asp Arg Lys Val Ser Gln 
            180                 185                 190         


Pro Ile Glu Gly His Ala Ala Ala Phe Ala Glu Phe Lys Met Glu Gly 
        195                 200                 205             


Asn Ala Lys Pro Ala Thr Leu Phe Cys Phe Ala Val Arg Asn Pro Thr 
    210                 215                 220                 


Gly Gly Lys Leu His Ile Ile Glu Val Gly Gln Pro Ala Ala Gly Asn 
225                 230                 235                 240 


Gln Pro Phe Val Lys Lys Ala Val Asp Val Phe Phe Pro Pro Glu Ala 
                245                 250                 255     


Gln Asn Asp Phe Pro Val Ala Met Gln Ile Gly Ala Lys His Gly Val 
            260                 265                 270         


Ile Tyr Leu Ile Thr Lys Tyr Gly Tyr Leu His Leu Tyr Asp Leu Glu 
        275                 280                 285             


Ser Gly Val Cys Ile Cys Met Asn Arg Ile Ser Ala Asp Thr Ile Phe 
    290                 295                 300                 


Val Thr Ala Pro His Lys Pro Thr Ser Gly Ile Ile Gly Val Asn Lys 
305                 310                 315                 320 


Lys Gly Gln Val Leu Ser Val Cys Val Glu Glu Asp Asn Ile Val Asn 
                325                 330                 335     


Tyr Ala Thr Asn Val Leu Gln Asn Pro Asp Leu Gly Leu Arg Leu Ala 
            340                 345                 350         


Val Arg Ser Asn Leu Ala Gly Ala Glu Lys Leu Phe Val Arg Lys Phe 
        355                 360                 365             


Asn Thr Leu Phe Ala Gln Gly Ser Tyr Ala Glu Ala Ala Lys Val Ala 
    370                 375                 380                 


Ala Ser Ala Pro Lys Gly Ile Leu Arg Thr Arg Glu Thr Val Gln Lys 
385                 390                 395                 400 


Phe Gln Ser Ile Pro Ala Gln Ser Gly Gln Ala Ser Pro Leu Leu Gln 
                405                 410                 415     


Tyr Phe Gly Ile Leu Leu Asp Gln Gly Gln Leu Asn Lys Leu Glu Ser 
            420                 425                 430         


Leu Glu Leu Cys His Leu Val Leu Gln Gln Gly Arg Lys Gln Leu Leu 
        435                 440                 445             


Glu Lys Trp Leu Lys Glu Asp Lys Leu Glu Cys Ser Glu Glu Leu Gly 
    450                 455                 460                 


Asp Leu Val Lys Thr Thr Asp Pro Met Leu Ala Leu Ser Val Tyr Leu 
465                 470                 475                 480 


Arg Ala Asn Val Pro Ser Lys Val Ile Gln Cys Phe Ala Glu Thr Gly 
                485                 490                 495     


Gln Phe Gln Lys Ile Val Leu Tyr Ala Lys Lys Val Gly Tyr Thr Pro 
            500                 505                 510         


Asp Trp Ile Phe Leu Leu Arg Gly Val Met Lys Ile Ser Pro Glu Gln 
        515                 520                 525             


Gly Leu Gln Phe Ser Arg Met Leu Val Gln Asp Glu Glu Pro Leu Ala 
    530                 535                 540                 


Asn Ile Ser Gln Ile Val Asp Ile Phe Met Glu Asn Ser Leu Ile Gln 
545                 550                 555                 560 


Gln Cys Thr Ser Phe Leu Leu Asp Ala Leu Lys Asn Asn Arg Pro Ala 
                565                 570                 575     


Glu Gly Leu Leu Gln Thr Trp Leu Leu Glu Met Asn Leu Val His Ala 
            580                 585                 590         


Pro Gln Val Ala Asp Ala Ile Leu Gly Asn Lys Met Phe Thr His Tyr 
        595                 600                 605             


Asp Arg Ala His Ile Ala Gln Leu Cys Glu Lys Ala Gly Leu Leu Gln 
    610                 615                 620                 


Gln Ala Leu Glu His Tyr Thr Asp Leu Tyr Asp Ile Lys Arg Ala Val 
625                 630                 635                 640 


Val His Thr His Leu Leu Asn Pro Glu Trp Leu Val Asn Phe Phe Gly 
                645                 650                 655     


Ser Leu Ser Val Glu Asp Ser Val Glu Cys Leu His Ala Met Leu Ser 
            660                 665                 670         


Ala Asn Ile Arg Gln Asn Leu Gln Leu Cys Val Gln Val Ala Ser Lys 
        675                 680                 685             


Tyr His Glu Gln Leu Gly Thr Gln Ala Leu Val Glu Leu Phe Glu Ser 
    690                 695                 700                 


Phe Lys Ser Tyr Lys Gly Leu Phe Tyr Phe Leu Gly Ser Ile Val Asn 
705                 710                 715                 720 


Phe Ser Gln Asp Pro Asp Val His Leu Lys Tyr Ile Gln Ala Ala Cys 
                725                 730                 735     


Lys Thr Gly Gln Ile Lys Glu Val Glu Arg Ile Cys Arg Glu Ser Ser 
            740                 745                 750         


Cys Tyr Asn Pro Glu Arg Val Lys Asn Phe Leu Lys Glu Ala Lys Leu 
        755                 760                 765             


Thr Asp Gln Leu Pro Leu Ile Ile Val Cys Asp Arg Phe Gly Phe Val 
    770                 775                 780                 


His Asp Leu Val Leu Tyr Leu Tyr Arg Asn Asn Leu Gln Arg Tyr Ile 
785                 790                 795                 800 


Glu Ile Tyr Val Gln Lys Val Asn Pro Ser Arg Thr Pro Ala Val Ile 
                805                 810                 815     


Gly Gly Leu Leu Asp Val Asp Cys Ser Glu Glu Val Ile Lys His Leu 
            820                 825                 830         


Ile Met Ala Val Arg Gly Gln Phe Ser Thr Asp Glu Leu Val Ala Glu 
        835                 840                 845             


Val Glu Lys Arg Asn Arg Leu Lys Leu Leu Leu Pro Trp Leu Glu Ser 
    850                 855                 860                 


Gln Ile Gln Glu Gly Cys Glu Glu Pro Ala Thr His Asn Ala Leu Ala 
865                 870                 875                 880 


Lys Ile Tyr Ile Asp Ser Asn Asn Ser Pro Glu Cys Phe Leu Arg Glu 
                885                 890                 895     


Asn Ala Tyr Tyr Asp Ser Ser Val Val Gly Arg Tyr Cys Glu Lys Arg 
            900                 905                 910         


Asp Pro His Leu Ala Cys Val Ala Tyr Glu Arg Gly Gln Cys Asp Leu 
        915                 920                 925             


Glu Leu Ile Lys Val Cys Asn Glu Asn Ser Leu Phe Lys Ser Glu Ala 
    930                 935                 940                 


Arg Tyr Leu Val Cys Arg Lys Asp Pro Glu Leu Trp Ala His Val Leu 
945                 950                 955                 960 


Glu Glu Thr Asn Pro Ser Arg Arg Gln Leu Ile Asp Gln Val Val Gln 
                965                 970                 975     


Thr Ala Leu Ser Glu Thr Arg Asp Pro Glu Glu Ile Ser Val Thr Val 
            980                 985                 990         


Lys Ala Phe Met Thr Ala Asp Leu  Pro Asn Glu Leu Ile  Glu Leu Leu 
        995                 1000                 1005             


Glu Lys  Ile Val Leu Asp Asn  Ser Val Phe Ser Glu  His Arg Asn 
    1010                 1015                 1020             


Leu Gln  Asn Leu Leu Ile Leu  Thr Ala Ile Lys Ala  Asp Arg Thr 
    1025                 1030                 1035             


Arg Val  Met Glu Tyr Ile Ser  Arg Leu Asp Asn Tyr  Asp Ala Leu 
    1040                 1045                 1050             


Asp Ile  Ala Ser Ile Ala Val  Ser Ser Ala Leu Tyr  Glu Glu Ala 
    1055                 1060                 1065             


Phe Thr  Val Phe His Lys Phe  Asp Met Asn Ala Ser  Ala Ile Gln 
    1070                 1075                 1080             


Val Leu  Ile Glu His Ile Gly  Asn Leu Asp Arg Ala  Tyr Glu Phe 
    1085                 1090                 1095             


Ala Glu  Arg Cys Asn Glu Pro  Ala Val Trp Ser Gln  Leu Ala Gln 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Asp Leu  Val Lys Glu Ala Ile  Asn Ser Tyr 
    1115                 1120                 1125             


Ile Arg  Gly Asp Asp Pro Ser  Ser Tyr Leu Glu Val  Val Gln Ser 
    1130                 1135                 1140             


Ala Ser  Arg Ser Asn Asn Trp  Glu Asp Leu Val Lys  Phe Leu Gln 
    1145                 1150                 1155             


Met Ala  Arg Lys Lys Gly Arg  Glu Ser Tyr Ile Glu  Thr Glu Leu 
    1160                 1165                 1170             


Ile Phe  Ala Leu Ala Lys Thr  Ser Arg Val Ser Glu  Leu Glu Asp 
    1175                 1180                 1185             


Phe Ile  Asn Gly Pro Asn Asn  Ala His Ile Gln Gln  Val Gly Asp 
    1190                 1195                 1200             


Arg Cys  Tyr Glu Glu Gly Met  Tyr Glu Ala Ala Lys  Leu Leu Tyr 
    1205                 1210                 1215             


Ser Asn  Val Ser Asn Phe Ala  Arg Leu Ala Ser Thr  Leu Val His 
    1220                 1225                 1230             


Leu Gly  Glu Tyr Gln Ala Ala  Val Asp Asn Ser Arg  Lys Ala Ser 
    1235                 1240                 1245             


Ser Thr  Arg Thr Trp Lys Glu  Val Cys Phe Ala Cys  Met Asp Gly 
    1250                 1255                 1260             


Gln Glu  Phe Arg Phe Ala Gln  Leu Cys Gly Leu His  Ile Val Ile 
    1265                 1270                 1275             


His Ala  Asp Glu Leu Glu Glu  Leu Met Cys Tyr Tyr  Gln Asp Arg 
    1280                 1285                 1290             


Gly Tyr  Phe Glu Glu Leu Ile  Leu Leu Leu Glu Ala  Ala Leu Gly 
    1295                 1300                 1305             


Leu Glu  Arg Ala His Met Gly  Met Phe Thr Glu Leu  Ala Ile Leu 
    1310                 1315                 1320             


Tyr Ser  Lys Phe Lys Pro Gln  Lys Met Leu Glu His  Leu Glu Leu 
    1325                 1330                 1335             


Phe Trp  Ser Arg Val Asn Ile  Pro Lys Val Leu Arg  Ala Ala Glu 
    1340                 1345                 1350             


Gln Ala  His Leu Trp Ala Glu  Leu Val Phe Leu Tyr  Asp Lys Tyr 
    1355                 1360                 1365             


Glu Glu  Tyr Asp Asn Ala Val  Leu Thr Met Met Ser  His Pro Thr 
    1370                 1375                 1380             


Glu Ala  Trp Lys Glu Gly Gln  Phe Lys Asp Ile Ile  Thr Lys Val 
    1385                 1390                 1395             


Ala Asn  Val Glu Leu Cys Tyr  Arg Ala Leu Gln Phe  Tyr Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Pro Leu Leu Ile Asn  Asp Leu Leu Leu Val  Leu Ser Pro 
    1415                 1420                 1425             


Arg Leu  Asp His Thr Trp Thr  Val Ser Phe Phe Ser  Lys Ala Gly 
    1430                 1435                 1440             


Gln Leu  Pro Leu Val Lys Pro  Tyr Leu Arg Ser Val  Gln Ser His 
    1445                 1450                 1455             


Asn Asn  Lys Ser Val Asn Glu  Ala Leu Asn His Leu  Leu Thr Glu 
    1460                 1465                 1470             


Glu Glu  Asp Tyr Gln Asp Ala  Met Gln His Ala Ala  Glu Ser Arg 
    1475                 1480                 1485             


Asp Ala  Glu Leu Ala Gln Lys  Leu Leu Gln Trp Phe  Leu Glu Glu 
    1490                 1495                 1500             


Gly Lys  Arg Glu Cys Phe Ala  Ala Cys Leu Phe Thr  Cys Tyr Asp 
    1505                 1510                 1515             


Leu Leu  Arg Pro Asp Met Val  Leu Glu Leu Ala Trp  Arg His Asn 
    1520                 1525                 1530             


Leu Val  Asp Leu Ala Met Pro  Tyr Phe Ile Gln Val  Met Arg Glu 
    1535                 1540                 1545             


Tyr Leu  Ser Lys Val Asp Lys  Leu Asp Ala Leu Glu  Ser Leu Arg 
    1550                 1555                 1560             


Lys Gln  Glu Glu His Val Thr  Glu Pro Ala Pro Leu  Val Phe Asp 
    1565                 1570                 1575             


Phe Asp  Gly His Glu 
    1580             


<210>  2309
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLUAP1__Homo_sapiens__NP_055856

<400>  2309

Met Ser Phe Arg Asp Leu Arg Asn Phe Thr Glu Met Met Arg Ala Leu 
1               5                   10                  15      


Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Thr Pro Asn Phe 
            20                  25                  30          


Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro 
        35                  40                  45              


Gln Thr Asp Ile Pro Pro Asp Val Asp Thr Glu Gln Asp Arg Val Phe 
    50                  55                  60                  


Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Thr Lys Ala His Ile Lys 
65                  70                  75                  80  


Leu Asn Thr Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu 
                85                  90                  95      


Leu Leu Lys Ile Thr Ser Val Leu Tyr Asn Ala Met Lys Thr Lys Gly 
            100                 105                 110         


Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe 
        115                 120                 125             


Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala 
    130                 135                 140                 


Ser Glu Ile Thr Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met 
145                 150                 155                 160 


Glu Val Glu Leu Arg Glu Met Arg Thr Glu Ala Ile Ala Arg Pro Leu 
                165                 170                 175     


Glu Ile Asn Glu Thr Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile 
            180                 185                 190         


Leu Thr Gln Val Gln Lys Thr Lys Asp Leu Leu Asn Asn Val Ala Ser 
        195                 200                 205             


Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu 
    210                 215                 220                 


Glu Arg Asn Arg Lys Arg Leu Glu Thr Leu Gln Ser Val Arg Pro Cys 
225                 230                 235                 240 


Phe Met Asp Glu Tyr Glu Lys Thr Glu Glu Glu Leu Gln Lys Gln Tyr 
                245                 250                 255     


Asp Thr Tyr Leu Glu Lys Phe Gln Asn Leu Thr Tyr Leu Glu Gln Gln 
            260                 265                 270         


Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys 
        275                 280                 285             


Asn Thr Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg 
    290                 295                 300                 


Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu 
305                 310                 315                 320 


Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro 
                325                 330                 335     


Gln Thr Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile 
            340                 345                 350         


Val Gly Thr Met Gln Gly Gly Asp Ser Asp Asp Asn Glu Asp Ser Glu 
        355                 360                 365             


Glu Ser Glu Ile Asp Met Glu Asp Asp Asp Asp Glu Asp Asp Asp Leu 
    370                 375                 380                 


Glu Asp Glu Ser Ile Ser Leu Ser Pro Thr Lys Pro Asn Arg Arg Val 
385                 390                 395                 400 


Arg Lys Ser Glu Pro Leu Asp Glu Ser Asp Asn Asp Phe 
                405                 410             


<210>  2310
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLU__Homo_sapiens__NP_001822

<400>  2310

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  2311
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLUL1__Homo_sapiens__NP_001275965

<400>  2311

Met Arg Thr Trp Asp Tyr Arg Trp Ser Leu Ala Leu Val Ala Gln Thr 
1               5                   10                  15      


Gly Val His Cys Cys Asn Leu Ser Ser Leu Gln Pro Leu Pro Pro Arg 
            20                  25                  30          


Phe Lys Arg Phe Ser Cys Leu Ser Leu Ser Ser Gly Trp Asp Tyr Ser 
        35                  40                  45              


Asn Ser Gly Asn Met Lys Pro Pro Leu Leu Val Phe Ile Val Cys Leu 
    50                  55                  60                  


Leu Trp Leu Lys Asp Ser His Cys Ala Pro Thr Trp Lys Asp Lys Thr 
65                  70                  75                  80  


Ala Ile Ser Glu Asn Leu Lys Ser Phe Ser Glu Val Gly Glu Ile Asp 
                85                  90                  95      


Ala Asp Glu Glu Val Lys Lys Ala Leu Thr Gly Ile Lys Gln Met Lys 
            100                 105                 110         


Ile Met Met Glu Arg Lys Glu Lys Glu His Thr Asn Leu Met Ser Thr 
        115                 120                 125             


Leu Lys Lys Cys Arg Glu Glu Lys Gln Glu Ala Leu Lys Leu Leu Asn 
    130                 135                 140                 


Glu Val Gln Glu His Leu Glu Glu Glu Glu Arg Leu Cys Arg Glu Ser 
145                 150                 155                 160 


Leu Ala Asp Ser Trp Gly Glu Cys Arg Ser Cys Leu Glu Asn Asn Cys 
                165                 170                 175     


Met Arg Ile Tyr Thr Thr Cys Gln Pro Ser Trp Ser Ser Val Lys Asn 
            180                 185                 190         


Lys Ile Glu Arg Phe Phe Arg Lys Ile Tyr Gln Phe Leu Phe Pro Phe 
        195                 200                 205             


His Glu Asp Asn Glu Lys Asp Leu Pro Ile Ser Glu Lys Leu Ile Glu 
    210                 215                 220                 


Glu Asp Ala Gln Leu Thr Gln Met Glu Asp Val Phe Ser Gln Leu Thr 
225                 230                 235                 240 


Val Asp Val Asn Ser Leu Phe Asn Arg Ser Phe Asn Val Phe Arg Gln 
                245                 250                 255     


Met Gln Gln Glu Phe Asp Gln Thr Phe Gln Ser His Phe Ile Ser Asp 
            260                 265                 270         


Thr Asp Leu Thr Glu Pro Tyr Phe Phe Pro Ala Phe Ser Lys Glu Pro 
        275                 280                 285             


Met Thr Lys Ala Asp Leu Glu Gln Cys Trp Asp Ile Pro Asn Phe Phe 
    290                 295                 300                 


Gln Leu Phe Cys Asn Phe Ser Val Ser Ile Tyr Glu Ser Val Ser Glu 
305                 310                 315                 320 


Thr Ile Thr Lys Met Leu Lys Ala Ile Glu Asp Leu Pro Lys Gln Asp 
                325                 330                 335     


Lys Ala Pro Asp His Gly Gly Leu Ile Ser Lys Met Leu Pro Gly Gln 
            340                 345                 350         


Asp Arg Gly Leu Cys Gly Glu Leu Asp Gln Asn Leu Ser Arg Cys Phe 
        355                 360                 365             


Lys Phe His Glu Lys Cys Gln Lys Cys Gln Ala His Leu Ser Glu Asp 
    370                 375                 380                 


Cys Pro Asp Val Pro Ala Leu His Thr Glu Leu Asp Glu Ala Ile Arg 
385                 390                 395                 400 


Leu Val Asn Val Ser Asn Gln Gln Tyr Gly Gln Ile Leu Gln Met Thr 
                405                 410                 415     


Arg Lys His Leu Glu Asp Thr Ala Tyr Leu Val Glu Lys Met Arg Gly 
            420                 425                 430         


Gln Phe Gly Trp Val Ser Glu Leu Ala Asn Gln Ala Pro Glu Thr Glu 
        435                 440                 445             


Ile Ile Phe Asn Ser Ile Gln Val Val Pro Arg Ile His Glu Gly Asn 
    450                 455                 460                 


Ile Ser Lys Gln Asp Glu Thr Met Met Thr Asp Leu Ser Ile Leu Pro 
465                 470                 475                 480 


Ser Ser Asn Phe Thr Leu Lys Ile Pro Leu Glu Glu Ser Ala Glu Ser 
                485                 490                 495     


Ser Asn Phe Ile Gly Tyr Val Val Ala Lys Ala Leu Gln His Phe Lys 
            500                 505                 510         


Glu His Phe Lys Thr Trp 
        515             


<210>  2312
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLVS1__Homo_sapiens__NP_775790

<400>  2312

Met Gly Pro Val Ser Leu Leu Pro Lys Tyr Gln Lys Leu Asn Thr Trp 
1               5                   10                  15      


Asn Gly Asp Leu Ala Lys Met Thr His Leu Gln Ala Gly Leu Ser Pro 
            20                  25                  30          


Glu Thr Ile Glu Lys Ala Arg Leu Glu Leu Asn Glu Asn Pro Asp Val 
        35                  40                  45              


Leu His Gln Asp Ile Gln Gln Val Arg Asp Met Ile Ile Thr Arg Pro 
    50                  55                  60                  


Asp Ile Gly Phe Leu Arg Thr Asp Asp Ala Phe Ile Leu Arg Phe Leu 
65                  70                  75                  80  


Arg Ala Arg Lys Phe His Gln Ala Asp Ala Phe Arg Leu Leu Ala Gln 
                85                  90                  95      


Tyr Phe Gln Tyr Arg Gln Leu Asn Leu Asp Met Phe Lys Asn Phe Lys 
            100                 105                 110         


Ala Asp Asp Pro Gly Ile Lys Arg Ala Leu Ile Asp Gly Phe Pro Gly 
        115                 120                 125             


Val Leu Glu Asn Arg Asp His Tyr Gly Arg Lys Ile Leu Leu Leu Phe 
    130                 135                 140                 


Ala Ala Asn Trp Asp Gln Ser Arg Asn Ser Phe Thr Asp Ile Leu Arg 
145                 150                 155                 160 


Ala Ile Leu Leu Ser Leu Glu Val Leu Ile Glu Asp Pro Glu Leu Gln 
                165                 170                 175     


Ile Asn Gly Phe Ile Leu Ile Ile Asp Trp Ser Asn Phe Ser Phe Lys 
            180                 185                 190         


Gln Ala Ser Lys Leu Thr Pro Ser Ile Leu Lys Leu Ala Ile Glu Gly 
        195                 200                 205             


Leu Gln Asp Ser Phe Pro Ala Arg Phe Gly Gly Val His Phe Val Asn 
    210                 215                 220                 


Gln Pro Trp Tyr Ile His Ala Leu Tyr Thr Leu Ile Lys Pro Phe Leu 
225                 230                 235                 240 


Lys Asp Lys Thr Arg Lys Arg Ile Phe Leu His Gly Asn Asn Leu Asn 
                245                 250                 255     


Ser Leu His Gln Leu Ile His Pro Glu Phe Leu Pro Ser Glu Phe Gly 
            260                 265                 270         


Gly Thr Leu Pro Pro Tyr Asp Met Gly Thr Trp Ala Arg Thr Leu Leu 
        275                 280                 285             


Gly Pro Asp Tyr Ser Asp Glu Asn Asp Tyr Thr His Thr Ser Tyr Asn 
    290                 295                 300                 


Ala Met His Val Lys His Thr Ser Ser Asn Leu Glu Arg Glu Cys Ser 
305                 310                 315                 320 


Pro Lys Leu Met Lys Arg Ser Gln Ser Val Val Glu Ala Gly Thr Leu 
                325                 330                 335     


Lys His Glu Glu Lys Gly Glu Asn Glu Asn Thr Gln Pro Leu Leu Ala 
            340                 345                 350         


Leu Asp 
        


<210>  2313
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLYBL__Homo_sapiens__NP_996531

<400>  2313

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Leu Leu Arg Leu Lys Ala Ser Leu Ala Ala Asp Ile Pro Arg Leu 
            20                  25                  30          


Gly Tyr Ser Ser Ser Ser His His Lys Tyr Ile Pro Arg Arg Ala Val 
        35                  40                  45              


Leu Tyr Val Pro Gly Asn Asp Glu Lys Lys Ile Lys Lys Ile Pro Ser 
    50                  55                  60                  


Leu Asn Val Asp Cys Ala Val Leu Asp Cys Glu Asp Gly Val Ala Ala 
65                  70                  75                  80  


Asn Lys Lys Asn Glu Ala Arg Leu Arg Ile Val Lys Thr Leu Glu Asp 
                85                  90                  95      


Ile Asp Leu Gly Pro Thr Glu Lys Cys Val Arg Val Asn Ser Val Ser 
            100                 105                 110         


Ser Gly Leu Ala Glu Glu Asp Leu Glu Thr Leu Leu Gln Ser Arg Val 
        115                 120                 125             


Leu Pro Ser Ser Leu Met Leu Pro Lys Val Glu Ser Pro Glu Glu Ile 
    130                 135                 140                 


Gln Trp Phe Ala Asp Lys Phe Ser Phe His Leu Lys Gly Arg Lys Leu 
145                 150                 155                 160 


Glu Gln Pro Met Asn Leu Ile Pro Phe Val Glu Thr Ala Met Gly Leu 
                165                 170                 175     


Leu Asn Phe Lys Ala Val Cys Glu Glu Thr Leu Lys Val Gly Pro Gln 
            180                 185                 190         


Val Gly Leu Phe Leu Asp Ala Val Val Phe Gly Gly Glu Asp Phe Arg 
        195                 200                 205             


Ala Ser Ile Gly Ala Thr Ser Ser Lys Glu Thr Leu Asp Ile Leu Tyr 
    210                 215                 220                 


Ala Arg Gln Lys Ile Val Val Ile Ala Lys Ala Phe Gly Leu Gln Ala 
225                 230                 235                 240 


Ile Asp Leu Val Tyr Ile Asp Phe Arg Asp Gly Ala Gly Leu Leu Arg 
                245                 250                 255     


Gln Ser Arg Glu Gly Ala Ala Met Gly Phe Thr Gly Lys Gln Val Ile 
            260                 265                 270         


His Pro Asn Gln Ile Ala Val Val Gln Glu Gln Phe Ser Pro Ser Pro 
        275                 280                 285             


Glu Lys Ile Lys Trp Ala Glu Glu Leu Ile Ala Ala Phe Lys Glu His 
    290                 295                 300                 


Gln Gln Leu Gly Lys Gly Ala Phe Thr Phe Gln Gly Ser Met Ile Asp 
305                 310                 315                 320 


Met Pro Leu Leu Lys Gln Ala Gln Asn Thr Val Thr Leu Ala Thr Ser 
                325                 330                 335     


Ile Lys Glu Lys 
            340 


<210>  2314
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMA1__Homo_sapiens__NP_001827

<400>  2314

Met Leu Leu Leu Pro Leu Pro Leu Leu Leu Phe Leu Leu Cys Ser Arg 
1               5                   10                  15      


Ala Glu Ala Gly Glu Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser 
            20                  25                  30          


Arg Pro Tyr Met Ala Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser 
        35                  40                  45              


Lys Phe Cys Gly Gly Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala 
    50                  55                  60                  


Ala His Cys Ala Gly Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn 
65                  70                  75                  80  


Ile Thr Glu Glu Glu Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln 
                85                  90                  95      


Phe Arg His Pro Lys Tyr Asn Thr Ser Thr Leu His His Asp Ile Met 
            100                 105                 110         


Leu Leu Lys Leu Lys Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr 
        115                 120                 125             


Leu Pro Phe Pro Ser Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys 
    130                 135                 140                 


Arg Val Ala Gly Trp Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp 
145                 150                 155                 160 


Thr Leu Gln Glu Val Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser 
                165                 170                 175     


His Phe Arg Asp Phe Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro 
            180                 185                 190         


Arg Lys Thr Lys Ser Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu 
        195                 200                 205             


Cys Ala Gly Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala 
    210                 215                 220                 


Lys Pro Pro Ala Val Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile 
225                 230                 235                 240 


Asn Gln Ile Leu Gln Ala Asn 
                245         


<210>  2315
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMAS__Homo_sapiens__NP_061156

<400>  2315

Met Asp Ser Val Glu Lys Gly Ala Ala Thr Ser Val Ser Asn Pro Arg 
1               5                   10                  15      


Gly Arg Pro Ser Arg Gly Arg Pro Pro Lys Leu Gln Arg Asn Ser Arg 
            20                  25                  30          


Gly Gly Gln Gly Arg Gly Val Glu Lys Pro Pro His Leu Ala Ala Leu 
        35                  40                  45              


Ile Leu Ala Arg Gly Gly Ser Lys Gly Ile Pro Leu Lys Asn Ile Lys 
    50                  55                  60                  


His Leu Ala Gly Val Pro Leu Ile Gly Trp Val Leu Arg Ala Ala Leu 
65                  70                  75                  80  


Asp Ser Gly Ala Phe Gln Ser Val Trp Val Ser Thr Asp His Asp Glu 
                85                  90                  95      


Ile Glu Asn Val Ala Lys Gln Phe Gly Ala Gln Val His Arg Arg Ser 
            100                 105                 110         


Ser Glu Val Ser Lys Asp Ser Ser Thr Ser Leu Asp Ala Ile Ile Glu 
        115                 120                 125             


Phe Leu Asn Tyr His Asn Glu Val Asp Ile Val Gly Asn Ile Gln Ala 
    130                 135                 140                 


Thr Ser Pro Cys Leu His Pro Thr Asp Leu Gln Lys Val Ala Glu Met 
145                 150                 155                 160 


Ile Arg Glu Glu Gly Tyr Asp Ser Val Phe Ser Val Val Arg Arg His 
                165                 170                 175     


Gln Phe Arg Trp Ser Glu Ile Gln Lys Gly Val Arg Glu Val Thr Glu 
            180                 185                 190         


Pro Leu Asn Leu Asn Pro Ala Lys Arg Pro Arg Arg Gln Asp Trp Asp 
        195                 200                 205             


Gly Glu Leu Tyr Glu Asn Gly Ser Phe Tyr Phe Ala Lys Arg His Leu 
    210                 215                 220                 


Ile Glu Met Gly Tyr Leu Gln Gly Gly Lys Met Ala Tyr Tyr Glu Met 
225                 230                 235                 240 


Arg Ala Glu His Ser Val Asp Ile Asp Val Asp Ile Asp Trp Pro Ile 
                245                 250                 255     


Ala Glu Gln Arg Val Leu Arg Tyr Gly Tyr Phe Gly Lys Glu Lys Leu 
            260                 265                 270         


Lys Glu Ile Lys Leu Leu Val Cys Asn Ile Asp Gly Cys Leu Thr Asn 
        275                 280                 285             


Gly His Ile Tyr Val Ser Gly Asp Gln Lys Glu Ile Ile Ser Tyr Asp 
    290                 295                 300                 


Val Lys Asp Ala Ile Gly Ile Ser Leu Leu Lys Lys Ser Gly Ile Glu 
305                 310                 315                 320 


Val Arg Leu Ile Ser Glu Arg Ala Cys Ser Lys Gln Thr Leu Ser Ser 
                325                 330                 335     


Leu Lys Leu Asp Cys Lys Met Glu Val Ser Val Ser Asp Lys Leu Ala 
            340                 345                 350         


Val Val Asp Glu Trp Arg Lys Glu Met Gly Leu Cys Trp Lys Glu Val 
        355                 360                 365             


Ala Tyr Leu Gly Asn Glu Val Ser Asp Glu Glu Cys Leu Lys Arg Val 
    370                 375                 380                 


Gly Leu Ser Gly Ala Pro Ala Asp Ala Cys Ser Thr Ala Gln Lys Ala 
385                 390                 395                 400 


Val Gly Tyr Ile Cys Lys Cys Asn Gly Gly Arg Gly Ala Ile Arg Glu 
                405                 410                 415     


Phe Ala Glu His Ile Cys Leu Leu Met Glu Lys Val Asn Asn Ser Cys 
            420                 425                 430         


Gln Lys 
        


<210>  2316
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMC1__Homo_sapiens__NP_872329

<400>  2316

Met Ala Leu Asp Pro Ala Asp Gln His Leu Arg His Val Glu Lys Asp 
1               5                   10                  15      


Val Leu Ile Pro Lys Ile Met Arg Glu Lys Ala Lys Glu Arg Cys Ser 
            20                  25                  30          


Glu Gln Val Gln Asp Phe Thr Lys Cys Cys Lys Asn Ser Gly Val Leu 
        35                  40                  45              


Met Val Val Lys Cys Arg Lys Glu Asn Ser Ala Leu Lys Glu Cys Leu 
    50                  55                  60                  


Thr Ala Tyr Tyr Asn Asp Pro Ala Phe Tyr Glu Glu Cys Lys Met Glu 
65                  70                  75                  80  


Tyr Leu Lys Glu Arg Glu Glu Phe Arg Lys Thr Gly Ile Pro Thr Lys 
                85                  90                  95      


Lys Arg Leu Gln Lys Leu Pro Thr Ser Met 
            100                 105     


<210>  2317
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMC2__Homo_sapiens__NP_064573

<400>  2317

Met His Pro Asp Leu Ser Pro His Leu His Thr Glu Glu Cys Asn Val 
1               5                   10                  15      


Leu Ile Asn Leu Leu Lys Glu Cys His Lys Asn His Asn Ile Leu Lys 
            20                  25                  30          


Phe Phe Gly Tyr Cys Asn Asp Val Asp Arg Glu Leu Arg Lys Cys Leu 
        35                  40                  45              


Lys Asn Glu Tyr Val Glu Asn Arg Thr Lys Ser Arg Glu His Gly Ile 
    50                  55                  60                  


Ala Met Arg Lys Lys Leu Phe Asn Pro Pro Glu Glu Ser Glu Lys 
65                  70                  75                  


<210>  2318
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMC4__Homo_sapiens__NP_001018024

<400>  2318

Met Pro Gln Lys Asp Pro Cys Gln Lys Gln Ala Cys Glu Ile Gln Lys 
1               5                   10                  15      


Cys Leu Gln Ala Asn Ser Tyr Met Glu Ser Lys Cys Gln Ala Val Ile 
            20                  25                  30          


Gln Glu Leu Arg Lys Cys Cys Ala Gln Tyr Pro Lys Gly Arg Ser Val 
        35                  40                  45              


Val Cys Ser Gly Phe Glu Lys Glu Glu Glu Glu Asn Leu Thr Arg Lys 
    50                  55                  60                  


Ser Ala Ser Lys 
65              


<210>  2319
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMIP__Homo_sapiens__NP_085132

<400>  2319

Met Gly Gln Ala Ala Glu Pro Thr Gly Tyr Met Glu Asn Ser Val Ser 
1               5                   10                  15      


Tyr Ser Ala Ile Glu Asp Val Gln Leu Leu Ser Trp Glu Asn Ala Pro 
            20                  25                  30          


Lys Tyr Cys Leu Gln Leu Thr Ile Pro Gly Gly Thr Val Leu Leu Gln 
        35                  40                  45              


Ala Ala Asn Ser Tyr Leu Arg Asp Gln Trp Phe His Ser Leu Gln Trp 
    50                  55                  60                  


Lys Lys Lys Ile Tyr Lys Tyr Lys Lys Val Leu Ser Asn Pro Ser Arg 
65                  70                  75                  80  


Trp Glu Val Val Leu Lys Glu Ile Arg Thr Leu Val Asp Met Ala Leu 
                85                  90                  95      


Thr Ser Pro Leu Gln Asp Asp Ser Ile Asn Gln Ala Pro Leu Glu Ile 
            100                 105                 110         


Val Ser Lys Leu Leu Ser Glu Asn Thr Asn Leu Thr Thr Gln Glu His 
        115                 120                 125             


Glu Asn Ile Ile Val Ala Ile Ala Pro Leu Leu Glu Asn Asn His Pro 
    130                 135                 140                 


Pro Pro Asp Leu Cys Glu Phe Phe Cys Lys His Cys Arg Glu Arg Pro 
145                 150                 155                 160 


Arg Ser Met Val Val Ile Glu Val Phe Thr Pro Val Val Gln Arg Ile 
                165                 170                 175     


Leu Lys His Asn Met Asp Phe Gly Lys Cys Pro Arg Leu Arg Leu Phe 
            180                 185                 190         


Thr Gln Glu Tyr Ile Leu Ala Leu Asn Glu Leu Asn Ala Gly Met Glu 
        195                 200                 205             


Val Val Lys Lys Phe Ile Gln Ser Met His Gly Pro Thr Gly His Cys 
    210                 215                 220                 


Pro His Pro Arg Val Leu Pro Asn Leu Val Ala Val Cys Leu Ala Ala 
225                 230                 235                 240 


Ile Tyr Ser Cys Tyr Glu Glu Phe Ile Asn Ser Arg Asp Asn Ser Pro 
                245                 250                 255     


Ser Leu Lys Glu Ile Arg Asn Gly Cys Gln Gln Pro Cys Asp Arg Lys 
            260                 265                 270         


Pro Thr Leu Pro Leu Arg Leu Leu His Pro Ser Pro Asp Leu Val Ser 
        275                 280                 285             


Gln Glu Ala Thr Leu Ser Glu Ala Arg Leu Lys Ser Val Val Val Ala 
    290                 295                 300                 


Ser Ser Glu Ile His Val Glu Val Glu Arg Thr Ser Thr Ala Lys Pro 
305                 310                 315                 320 


Ala Leu Thr Ala Ser Ala Gly Asn Asp Ser Glu Pro Asn Leu Ile Asp 
                325                 330                 335     


Cys Leu Met Val Ser Pro Ala Cys Ser Thr Met Ser Ile Glu Leu Gly 
            340                 345                 350         


Pro Gln Ala Asp Arg Thr Leu Gly Cys Tyr Val Glu Ile Leu Lys Leu 
        355                 360                 365             


Leu Ser Asp Tyr Asp Asp Trp Arg Pro Ser Leu Ala Ser Leu Leu Gln 
    370                 375                 380                 


Pro Ile Pro Phe Pro Lys Glu Ala Leu Ala His Glu Lys Phe Thr Lys 
385                 390                 395                 400 


Glu Leu Lys Tyr Val Ile Gln Arg Phe Ala Glu Asp Pro Arg Gln Glu 
                405                 410                 415     


Val His Ser Cys Leu Leu Ser Val Arg Ala Gly Lys Asp Gly Trp Phe 
            420                 425                 430         


Gln Leu Tyr Ser Pro Gly Gly Val Ala Cys Asp Asp Asp Gly Glu Leu 
        435                 440                 445             


Phe Ala Ser Met Val His Ile Leu Met Gly Ser Cys Tyr Lys Thr Lys 
    450                 455                 460                 


Lys Phe Leu Leu Ser Leu Ala Glu Asn Lys Leu Gly Pro Cys Met Leu 
465                 470                 475                 480 


Leu Ala Leu Arg Gly Asn Gln Thr Met Val Glu Ile Leu Cys Leu Met 
                485                 490                 495     


Leu Glu Tyr Asn Ile Ile Asp Asn Asn Asp Thr Gln Leu Gln Ile Ile 
            500                 505                 510         


Ser Thr Leu Glu Ser Thr Asp Val Gly Lys Arg Met Tyr Glu Gln Leu 
        515                 520                 525             


Cys Asp Arg Gln Arg Glu Leu Lys Glu Leu Gln Arg Lys Gly Gly Pro 
    530                 535                 540                 


Thr Arg Leu Thr Leu Pro Ser Lys Ser Thr Asp Ala Asp Leu Ala Arg 
545                 550                 555                 560 


Leu Leu Ser Ser Gly Ser Phe Gly Asn Leu Glu Asn Leu Ser Leu Ala 
                565                 570                 575     


Phe Thr Asn Val Thr Ser Ala Cys Ala Glu His Leu Ile Lys Leu Pro 
            580                 585                 590         


Ser Leu Lys Gln Leu Asn Leu Trp Ser Thr Gln Phe Gly Asp Ala Gly 
        595                 600                 605             


Leu Arg Leu Leu Ser Glu His Leu Thr Met Leu Gln Val Leu Asn Leu 
    610                 615                 620                 


Cys Glu Thr Pro Val Thr Asp Ala Gly Leu Leu Ala Leu Ser Ser Met 
625                 630                 635                 640 


Lys Ser Leu Cys Ser Leu Asn Met Asn Ser Thr Lys Leu Ser Ala Asp 
                645                 650                 655     


Thr Tyr Glu Asp Leu Lys Ala Lys Leu Pro Asn Leu Lys Glu Val Asp 
            660                 665                 670         


Val Arg Tyr Thr Glu Ala Trp 
        675                 


<210>  2320
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMKLR1__Homo_sapiens__NP_001135815

<400>  2320

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  2321
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMPK2__Homo_sapiens__NP_001243406

<400>  2321

Met Ala Phe Ala Arg Arg Leu Leu Arg Gly Pro Leu Ser Gly Pro Leu 
1               5                   10                  15      


Leu Gly Arg Arg Gly Val Cys Ala Gly Ala Met Ala Pro Pro Arg Arg 
            20                  25                  30          


Phe Val Leu Glu Leu Pro Asp Cys Thr Leu Ala His Phe Ala Leu Gly 
        35                  40                  45              


Ala Asp Ala Pro Gly Asp Ala Asp Ala Pro Asp Pro Arg Leu Ala Ala 
    50                  55                  60                  


Leu Leu Gly Pro Pro Glu Arg Ser Tyr Ser Leu Cys Val Pro Val Thr 
65                  70                  75                  80  


Pro Asp Ala Gly Cys Gly Ala Arg Val Arg Ala Ala Arg Leu His Gln 
                85                  90                  95      


Arg Leu Leu His Gln Leu Arg Arg Gly Pro Phe Gln Arg Cys Gln Leu 
            100                 105                 110         


Leu Arg Leu Leu Cys Tyr Cys Pro Gly Gly Gln Ala Gly Gly Ala Gln 
        115                 120                 125             


Gln Gly Phe Leu Leu Arg Asp Pro Leu Asp Asp Pro Asp Thr Arg Gln 
    130                 135                 140                 


Ala Leu Leu Glu Leu Leu Gly Ala Cys Gln Glu Ala Pro Arg Pro His 
145                 150                 155                 160 


Leu Gly Glu Phe Glu Ala Asp Pro Arg Gly Gln Leu Trp Gln Arg Leu 
                165                 170                 175     


Trp Glu Val Gln Asp Gly Arg Arg Leu Gln Val Gly Cys Ala Gln Val 
            180                 185                 190         


Val Pro Val Pro Glu Pro Pro Leu His Pro Val Val Pro Asp Leu Pro 
        195                 200                 205             


Ser Ser Val Val Phe Pro Asp Arg Glu Ala Ala Arg Ala Val Leu Glu 
    210                 215                 220                 


Glu Cys Thr Ser Phe Ile Pro Glu Ala Arg Ala Val Leu Asp Leu Val 
225                 230                 235                 240 


Asp Gln Cys Pro Lys Gln Ile Gln Lys Gly Lys Phe Gln Val Val Ala 
                245                 250                 255     


Ile Glu Gly Leu Asp Ala Thr Gly Lys Thr Thr Val Thr Gln Ser Val 
            260                 265                 270         


Ala Asp Ser Leu Lys Ala Val Leu Leu Lys Ser Pro Pro Ser Cys Ile 
        275                 280                 285             


Gly Gln Trp Arg Lys Ile Phe Asp Asp Glu Pro Thr Ile Ile Arg Arg 
    290                 295                 300                 


Ala Phe Tyr Ser Leu Gly Asn Tyr Ile Val Ala Ser Glu Ile Ala Lys 
305                 310                 315                 320 


Glu Ser Ala Lys Ser Pro Val Ile Val Asp Arg Tyr Trp His Ser Thr 
                325                 330                 335     


Ala Thr Tyr Ala Ile Ala Thr Glu Val Ser Gly Gly Leu Gln His Leu 
            340                 345                 350         


Pro Pro Ala His His Pro Val Tyr Gln Trp Pro Glu Asp Leu Leu Lys 
        355                 360                 365             


Pro Asp Leu Ile Leu Leu Leu Thr Val Ser Pro Glu Glu Arg Leu Gln 
    370                 375                 380                 


Arg Leu Gln Gly Arg Gly Met Glu Lys Thr Arg Glu Glu Ala Glu Leu 
385                 390                 395                 400 


Glu Ala Asn Ser Val Phe Arg Gln Lys 
                405                 


<210>  2322
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMSS1__Homo_sapiens__NP_001161396

<400>  2322

Met His Gly Glu Ala Ser Asp Gly Glu Gly Glu Gly Asp Thr Glu Val 
1               5                   10                  15      


Met Gln Gln Glu Thr Val Pro Val Pro Val Pro Ser Glu Lys Thr Lys 
            20                  25                  30          


Gln Pro Lys Glu Cys Phe Leu Ile Gln Pro Lys Glu Arg Lys Glu Asn 
        35                  40                  45              


Thr Thr Lys Thr Arg Lys Arg Arg Lys Lys Lys Ile Thr Asp Val Leu 
    50                  55                  60                  


Ala Lys Ser Glu Pro Lys Pro Gly Leu Pro Glu Asp Leu Gln Lys Leu 
65                  70                  75                  80  


Met Lys Asp Tyr Tyr Ser Ser Arg Arg Leu Val Ile Glu Leu Glu Glu 
                85                  90                  95      


Leu Asn Leu Pro Asp Ser Cys Phe Leu Lys Ala Asn Asp Leu Thr His 
            100                 105                 110         


Ser Leu Ser Ser Tyr Leu Lys Glu Ile Cys Pro Lys Trp Val Lys Leu 
        115                 120                 125             


Arg Lys Asn His Ser Glu Lys Lys Ser Val Leu Met Leu Ile Ile Cys 
    130                 135                 140                 


Ser Ser Ala Val Arg Ala Leu Glu Leu Ile Arg Ser Met Thr Ala Phe 
145                 150                 155                 160 


Arg Gly Asp Gly Lys Val Ile Lys Leu Phe Ala Lys His Ile Lys Val 
                165                 170                 175     


Gln Ala Gln Val Lys Leu Leu Glu Lys Arg Val Val His Leu Gly Val 
            180                 185                 190         


Gly Thr Pro Gly Arg Ile Lys Glu Leu Val Lys Gln Gly Gly Leu Asn 
        195                 200                 205             


Leu Ser Pro Leu Lys Phe Leu Val Phe Asp Trp Asn Trp Arg Asp Gln 
    210                 215                 220                 


Lys Leu Arg Arg Met Met Asp Ile Pro Glu Ile Arg Lys Glu Val Phe 
225                 230                 235                 240 


Glu Leu Leu Glu Met Gly Val Leu Ser Leu Cys Lys Ser Glu Ser Leu 
                245                 250                 255     


Lys Leu Gly Leu Phe 
            260     


<210>  2323
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMTM3__Homo_sapiens__NP_853531

<400>  2323

Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly 
1               5                   10                  15      


Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro 
            20                  25                  30          


Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu 
        35                  40                  45              


Ser Gly Leu Ser Phe Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala 
    50                  55                  60                  


Ser Ala Phe Leu Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr 
65                  70                  75                  80  


Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu 
                85                  90                  95      


Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile 
            100                 105                 110         


Tyr Phe Ala Ile Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala 
        115                 120                 125             


Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala 
    130                 135                 140                 


Thr Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln 
145                 150                 155                 160 


Gly Asp Ser Ala Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp 
            180         


<210>  2324
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMTM5__Homo_sapiens__NP_001032365

<400>  2324

Met Leu Ser Ala Arg Asp Arg Arg Asp Arg His Pro Glu Glu Gly Val 
1               5                   10                  15      


Val Ala Glu Leu Gln Gly Phe Ala Val Asp Lys Ala Phe Leu Thr Ser 
            20                  25                  30          


His Lys Gly Ile Leu Leu Glu Thr Glu Leu Ala Leu Thr Leu Ile Ile 
        35                  40                  45              


Phe Ile Cys Phe Thr Ala Ser Ile Ser Ala Tyr Met Ala Ala Ala Leu 
    50                  55                  60                  


Leu Glu Phe Phe Ile Thr Leu Ala Phe Leu Phe Leu Tyr Ala Thr Gln 
65                  70                  75                  80  


Tyr Tyr Gln Arg Phe Asp Arg Ile Asn Trp Pro Cys Leu Val Phe Gly 
                85                  90                  95      


Ile Ile Leu Val Ser Ile Phe Ala Tyr Asp Ala Phe Lys Ile Tyr Arg 
            100                 105                 110         


Thr Glu Met Ala Pro Gly Ala Ser Gln Gly Asp Gln Gln 
        115                 120                 125 


<210>  2325
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMTM7__Homo_sapiens__NP_612419

<400>  2325

Met Ser His Gly Ala Gly Leu Val Arg Thr Thr Cys Ser Ser Gly Ser 
1               5                   10                  15      


Ala Leu Gly Pro Gly Ala Gly Ala Ala Gln Pro Ser Ala Ser Pro Leu 
            20                  25                  30          


Glu Gly Leu Leu Asp Leu Ser Tyr Pro Arg Thr His Ala Ala Leu Leu 
        35                  40                  45              


Lys Val Ala Gln Met Val Thr Leu Leu Ile Ala Phe Ile Cys Val Arg 
    50                  55                  60                  


Ser Ser Leu Trp Thr Asn Tyr Ser Ala Tyr Ser Tyr Phe Glu Val Val 
65                  70                  75                  80  


Thr Ile Cys Asp Leu Ile Met Ile Leu Ala Phe Tyr Leu Val His Leu 
                85                  90                  95      


Phe Arg Phe Tyr Arg Val Leu Thr Cys Ile Ser Trp Pro Leu Ser Glu 
            100                 105                 110         


Leu Leu His Tyr Leu Ile Gly Thr Leu Leu Leu Leu Ile Ala Ser Ile 
        115                 120                 125             


Val Ala Ala Ser Lys Ser Tyr Asn Gln Ser Gly Leu Val Ala Gly Ala 
    130                 135                 140                 


Ile Phe Gly Phe Met Ala Thr Phe Leu Cys Met Ala Ser Ile Trp Leu 
145                 150                 155                 160 


Ser Tyr Lys Ile Ser Cys Val Thr Gln Ser Thr Asp Ala Ala Val 
                165                 170                 175 


<210>  2326
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMTM8__Homo_sapiens__NP_849199

<400>  2326

Met Glu Glu Pro Gln Arg Ala Arg Ser His Thr Val Thr Thr Thr Ala 
1               5                   10                  15      


Ser Ser Phe Ala Glu Asn Phe Ser Thr Ser Ser Ser Ser Phe Ala Tyr 
            20                  25                  30          


Asp Arg Glu Phe Leu Arg Thr Leu Pro Gly Phe Leu Ile Val Ala Glu 
        35                  40                  45              


Ile Val Leu Gly Leu Leu Val Trp Thr Leu Ile Ala Gly Thr Glu Tyr 
    50                  55                  60                  


Phe Arg Val Pro Ala Phe Gly Trp Val Met Phe Val Ala Val Phe Tyr 
65                  70                  75                  80  


Trp Val Leu Thr Val Phe Phe Leu Ile Ile Tyr Ile Thr Met Thr Tyr 
                85                  90                  95      


Thr Arg Ile Pro Gln Val Pro Trp Thr Thr Val Gly Leu Cys Phe Asn 
            100                 105                 110         


Gly Ser Ala Phe Val Leu Tyr Leu Ser Ala Ala Val Val Asp Ala Ser 
        115                 120                 125             


Ser Val Ser Pro Glu Arg Asp Ser His Asn Phe Asn Ser Trp Ala Ala 
    130                 135                 140                 


Ser Ser Phe Phe Ala Phe Leu Val Thr Ile Cys Tyr Ala Gly Asn Thr 
145                 150                 155                 160 


Tyr Phe Ser Phe Ile Ala Trp Arg Ser Arg Thr Ile Gln 
                165                 170             


<210>  2327
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMTR1__Homo_sapiens__NP_055865

<400>  2327

Met Lys Arg Arg Thr Asp Pro Glu Cys Thr Ala Pro Ile Lys Lys Gln 
1               5                   10                  15      


Lys Lys Arg Val Ala Glu Leu Ala Leu Ser Leu Ser Ser Thr Ser Asp 
            20                  25                  30          


Asp Glu Pro Pro Ser Ser Val Ser His Gly Ala Lys Ala Ser Thr Thr 
        35                  40                  45              


Ser Leu Ser Gly Ser Asp Ser Glu Thr Glu Gly Lys Gln His Ser Ser 
    50                  55                  60                  


Asp Ser Phe Asp Asp Ala Phe Lys Ala Asp Ser Leu Val Glu Gly Thr 
65                  70                  75                  80  


Ser Ser Arg Tyr Ser Met Tyr Asn Ser Val Ser Gln Lys Leu Met Ala 
                85                  90                  95      


Lys Met Gly Phe Arg Glu Gly Glu Gly Leu Gly Lys Tyr Ser Gln Gly 
            100                 105                 110         


Arg Lys Asp Ile Val Glu Ala Ser Ser Gln Lys Gly Arg Arg Gly Leu 
        115                 120                 125             


Gly Leu Thr Leu Arg Gly Phe Asp Gln Glu Leu Asn Val Asp Trp Arg 
    130                 135                 140                 


Asp Glu Pro Glu Pro Ser Ala Cys Glu Gln Val Ser Trp Phe Pro Glu 
145                 150                 155                 160 


Cys Thr Thr Glu Ile Pro Asp Thr Gln Glu Met Ser Asp Trp Met Val 
                165                 170                 175     


Val Gly Lys Arg Lys Met Ile Ile Glu Asp Glu Thr Glu Phe Cys Gly 
            180                 185                 190         


Glu Glu Leu Leu His Ser Val Leu Gln Cys Lys Ser Val Phe Asp Val 
        195                 200                 205             


Leu Asp Gly Glu Glu Met Arg Arg Ala Arg Thr Arg Ala Asn Pro Tyr 
    210                 215                 220                 


Glu Met Ile Arg Gly Val Phe Phe Leu Asn Arg Ala Ala Met Lys Met 
225                 230                 235                 240 


Ala Asn Met Asp Phe Val Phe Asp Arg Met Phe Thr Asn Pro Arg Asp 
                245                 250                 255     


Ser Tyr Gly Lys Pro Leu Val Lys Asp Arg Glu Ala Glu Leu Leu Tyr 
            260                 265                 270         


Phe Ala Asp Val Cys Ala Gly Pro Gly Gly Phe Ser Glu Tyr Val Leu 
        275                 280                 285             


Trp Arg Lys Lys Trp His Ala Lys Gly Phe Gly Met Thr Leu Lys Gly 
    290                 295                 300                 


Pro Asn Asp Phe Lys Leu Glu Asp Phe Tyr Ser Ala Ser Ser Glu Leu 
305                 310                 315                 320 


Phe Glu Pro Tyr Tyr Gly Glu Gly Gly Ile Asp Gly Asp Gly Asp Ile 
                325                 330                 335     


Thr Arg Pro Glu Asn Ile Ser Ala Phe Arg Asn Phe Val Leu Asp Asn 
            340                 345                 350         


Thr Asp Arg Lys Gly Val His Phe Leu Met Ala Asp Gly Gly Phe Ser 
        355                 360                 365             


Val Glu Gly Gln Glu Asn Leu Gln Glu Ile Leu Ser Lys Gln Leu Leu 
    370                 375                 380                 


Leu Cys Gln Phe Leu Met Ala Leu Ser Ile Val Arg Thr Gly Gly His 
385                 390                 395                 400 


Phe Ile Cys Lys Thr Phe Asp Leu Phe Thr Pro Phe Ser Val Gly Leu 
                405                 410                 415     


Val Tyr Leu Leu Tyr Cys Cys Phe Glu Arg Val Cys Leu Phe Lys Pro 
            420                 425                 430         


Ile Thr Ser Arg Pro Ala Asn Ser Glu Arg Tyr Val Val Cys Lys Gly 
        435                 440                 445             


Leu Lys Val Gly Ile Asp Asp Val Arg Asp Tyr Leu Phe Ala Val Asn 
    450                 455                 460                 


Ile Lys Leu Asn Gln Leu Arg Asn Thr Asp Ser Asp Val Asn Leu Val 
465                 470                 475                 480 


Val Pro Leu Glu Val Ile Lys Gly Asp His Glu Phe Thr Asp Tyr Met 
                485                 490                 495     


Ile Arg Ser Asn Glu Ser His Cys Ser Leu Gln Ile Lys Ala Leu Ala 
            500                 505                 510         


Lys Ile His Ala Phe Val Gln Asp Thr Thr Leu Ser Glu Pro Arg Gln 
        515                 520                 525             


Ala Glu Ile Arg Lys Glu Cys Leu Arg Leu Trp Gly Ile Pro Asp Gln 
    530                 535                 540                 


Ala Arg Val Ala Pro Ser Ser Ser Asp Pro Lys Ser Lys Phe Phe Glu 
545                 550                 555                 560 


Leu Ile Gln Gly Thr Glu Ile Asp Ile Phe Ser Tyr Lys Pro Thr Leu 
                565                 570                 575     


Leu Thr Ser Lys Thr Leu Glu Lys Ile Arg Pro Val Phe Asp Tyr Arg 
            580                 585                 590         


Cys Met Val Ser Gly Ser Glu Gln Lys Phe Leu Ile Gly Leu Gly Lys 
        595                 600                 605             


Ser Gln Ile Tyr Thr Trp Asp Gly Arg Gln Ser Asp Arg Trp Ile Lys 
    610                 615                 620                 


Leu Asp Leu Lys Thr Glu Leu Pro Arg Asp Thr Leu Leu Ser Val Glu 
625                 630                 635                 640 


Ile Val His Glu Leu Lys Gly Glu Gly Lys Ala Gln Arg Lys Ile Ser 
                645                 650                 655     


Ala Ile His Ile Leu Asp Val Leu Val Leu Asn Gly Thr Asp Val Arg 
            660                 665                 670         


Glu Gln His Phe Asn Gln Arg Ile Gln Leu Ala Glu Lys Phe Val Lys 
        675                 680                 685             


Ala Val Ser Lys Pro Ser Arg Pro Asp Met Asn Pro Ile Arg Val Lys 
    690                 695                 700                 


Glu Val Tyr Arg Leu Glu Glu Met Glu Lys Ile Phe Val Arg Leu Glu 
705                 710                 715                 720 


Met Lys Ile Ile Lys Gly Ser Ser Gly Thr Pro Lys Leu Ser Tyr Thr 
                725                 730                 735     


Gly Arg Asp Asp Arg His Phe Val Pro Met Gly Leu Tyr Ile Val Arg 
            740                 745                 750         


Thr Val Asn Glu Pro Trp Thr Met Gly Phe Ser Lys Ser Phe Lys Lys 
        755                 760                 765             


Lys Phe Phe Tyr Asn Lys Lys Thr Lys Asp Ser Thr Phe Asp Leu Pro 
    770                 775                 780                 


Ala Asp Ser Ile Ala Pro Phe His Ile Cys Tyr Tyr Gly Arg Leu Phe 
785                 790                 795                 800 


Trp Glu Trp Gly Asp Gly Ile Arg Val His Asp Ser Gln Lys Pro Gln 
                805                 810                 815     


Asp Gln Asp Lys Leu Ser Lys Glu Asp Val Leu Ser Phe Ile Gln Met 
            820                 825                 830         


His Arg Ala 
        835 


<210>  2328
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMTR2__Homo_sapiens__NP_060818

<400>  2328

Met Ser Lys Cys Arg Lys Thr Pro Val Gln Gln Leu Ala Ser Pro Ala 
1               5                   10                  15      


Ser Phe Ser Pro Asp Ile Leu Ala Asp Ile Phe Glu Leu Phe Ala Lys 
            20                  25                  30          


Asn Phe Ser Tyr Gly Lys Pro Leu Asn Asn Glu Trp Gln Leu Pro Asp 
        35                  40                  45              


Pro Ser Glu Ile Phe Thr Cys Asp His Thr Glu Leu Asn Ala Phe Leu 
    50                  55                  60                  


Asp Leu Lys Asn Ser Leu Asn Glu Val Lys Asn Leu Leu Ser Asp Lys 
65                  70                  75                  80  


Lys Leu Asp Glu Trp His Glu His Thr Ala Phe Thr Asn Lys Ala Gly 
                85                  90                  95      


Lys Ile Ile Ser His Val Arg Lys Ser Val Asn Ala Glu Leu Cys Thr 
            100                 105                 110         


Gln Ala Trp Cys Lys Phe His Glu Ile Leu Cys Ser Phe Pro Leu Ile 
        115                 120                 125             


Pro Gln Glu Ala Phe Gln Asn Gly Lys Leu Asn Ser Leu His Leu Cys 
    130                 135                 140                 


Glu Ala Pro Gly Ala Phe Ile Ala Ser Leu Asn His Tyr Leu Lys Ser 
145                 150                 155                 160 


His Arg Phe Pro Cys His Trp Ser Trp Val Ala Asn Thr Leu Asn Pro 
                165                 170                 175     


Tyr His Glu Ala Asn Asp Asp Leu Met Met Ile Met Asp Asp Arg Leu 
            180                 185                 190         


Ile Ala Asn Thr Leu His Trp Trp Tyr Phe Gly Pro Asp Asn Thr Gly 
        195                 200                 205             


Asp Ile Met Thr Leu Lys Phe Leu Thr Gly Leu Gln Asn Phe Ile Ser 
    210                 215                 220                 


Ser Met Ala Thr Val His Leu Val Thr Ala Asp Gly Ser Phe Asp Cys 
225                 230                 235                 240 


Gln Gly Asn Pro Gly Glu Gln Glu Ala Leu Val Ser Ser Leu His Tyr 
                245                 250                 255     


Cys Glu Val Val Thr Ala Leu Thr Thr Leu Gly Asn Gly Gly Ser Phe 
            260                 265                 270         


Val Leu Lys Met Phe Thr Met Phe Glu His Cys Ser Ile Asn Leu Met 
        275                 280                 285             


Tyr Leu Leu Asn Cys Cys Phe Asp Gln Val His Val Phe Lys Pro Ala 
    290                 295                 300                 


Thr Ser Lys Ala Gly Asn Ser Glu Val Tyr Val Val Cys Leu His Tyr 
305                 310                 315                 320 


Lys Gly Arg Glu Ala Ile His Pro Leu Leu Ser Lys Met Thr Leu Asn 
                325                 330                 335     


Phe Gly Thr Glu Met Lys Arg Lys Ala Leu Phe Pro His His Val Ile 
            340                 345                 350         


Pro Asp Ser Phe Leu Lys Arg His Glu Glu Cys Cys Val Phe Phe His 
        355                 360                 365             


Lys Tyr Gln Leu Glu Thr Ile Ser Glu Asn Ile Arg Leu Phe Glu Cys 
    370                 375                 380                 


Met Gly Lys Ala Glu Gln Glu Lys Leu Asn Asn Leu Arg Asp Cys Ala 
385                 390                 395                 400 


Ile Gln Tyr Phe Met Gln Lys Phe Gln Leu Lys His Leu Ser Arg Asn 
                405                 410                 415     


Asn Trp Leu Val Lys Lys Ser Ser Ile Gly Cys Ser Thr Asn Thr Lys 
            420                 425                 430         


Trp Phe Gly Gln Arg Asn Lys Tyr Phe Lys Thr Tyr Asn Glu Arg Lys 
        435                 440                 445             


Met Leu Glu Ala Leu Ser Trp Lys Asp Lys Val Ala Lys Gly Tyr Phe 
    450                 455                 460                 


Asn Ser Trp Ala Glu Glu His Gly Val Tyr His Pro Gly Gln Ser Ser 
465                 470                 475                 480 


Ile Leu Glu Gly Thr Ala Ser Asn Leu Glu Cys His Leu Trp His Ile 
                485                 490                 495     


Leu Glu Gly Lys Lys Leu Pro Lys Val Lys Cys Ser Pro Phe Cys Asn 
            500                 505                 510         


Gly Glu Ile Leu Lys Thr Leu Asn Glu Ala Ile Glu Lys Ser Leu Gly 
        515                 520                 525             


Gly Ala Phe Asn Leu Asp Ser Lys Phe Arg Pro Lys Gln Gln Tyr Ser 
    530                 535                 540                 


Cys Ser Cys His Val Phe Ser Glu Glu Leu Ile Phe Ser Glu Leu Cys 
545                 550                 555                 560 


Ser Leu Thr Glu Cys Leu Gln Asp Glu Gln Val Val Val Pro Ser Asn 
                565                 570                 575     


Gln Ile Lys Cys Leu Leu Val Gly Phe Ser Thr Leu Arg Asn Ile Lys 
            580                 585                 590         


Met His Ile Pro Leu Glu Val Arg Leu Leu Glu Ser Ala Glu Leu Thr 
        595                 600                 605             


Thr Phe Ser Cys Ser Leu Leu His Asp Gly Asp Pro Thr Tyr Gln Arg 
    610                 615                 620                 


Leu Phe Leu Asp Cys Leu Leu His Ser Leu Arg Glu Leu His Thr Gly 
625                 630                 635                 640 


Asp Val Met Ile Leu Pro Val Leu Ser Cys Phe Thr Arg Phe Met Ala 
                645                 650                 655     


Gly Leu Ile Phe Val Leu His Ser Cys Phe Arg Phe Ile Thr Phe Val 
            660                 665                 670         


Cys Pro Thr Ser Ser Asp Pro Leu Arg Thr Cys Ala Val Leu Leu Cys 
        675                 680                 685             


Val Gly Tyr Gln Asp Leu Pro Asn Pro Val Phe Arg Tyr Leu Gln Ser 
    690                 695                 700                 


Val Asn Glu Leu Leu Ser Thr Leu Leu Asn Ser Asp Ser Pro Gln Gln 
705                 710                 715                 720 


Val Leu Gln Phe Val Pro Met Glu Val Leu Leu Lys Gly Ala Leu Leu 
                725                 730                 735     


Asp Phe Leu Trp Asp Leu Asn Ala Ala Ile Ala Lys Arg His Leu His 
            740                 745                 750         


Phe Ile Ile Gln Arg Glu Arg Glu Glu Ile Ile Asn Ser Leu Gln Leu 
        755                 760                 765             


Gln Asn 
    770 


<210>  2329
<211>  4069
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMYA5__Homo_sapiens__NP_705838

<400>  2329

Met Ala Ser Arg Asp Ser Asn His Ala Gly Glu Ser Phe Leu Gly Ser 
1               5                   10                  15      


Asp Gly Asp Glu Glu Ala Thr Arg Glu Leu Glu Thr Glu Glu Glu Ser 
            20                  25                  30          


Glu Gly Glu Glu Asp Glu Thr Ala Ala Glu Ser Glu Glu Glu Pro Asp 
        35                  40                  45              


Ser Arg Leu Ser Asp Gln Asp Glu Glu Gly Lys Ile Lys Gln Glu Tyr 
    50                  55                  60                  


Ile Ile Ser Asp Pro Ser Phe Ser Met Val Thr Val Gln Arg Glu Asp 
65                  70                  75                  80  


Ser Gly Ile Thr Trp Glu Thr Asn Ser Ser Arg Ser Ser Thr Pro Trp 
                85                  90                  95      


Ala Ser Glu Glu Ser Gln Thr Ser Gly Val Cys Ser Arg Glu Gly Ser 
            100                 105                 110         


Thr Val Asn Ser Pro Pro Gly Asn Val Ser Phe Ile Val Asp Glu Val 
        115                 120                 125             


Lys Lys Val Arg Lys Arg Thr His Lys Ser Lys His Gly Ser Pro Ser 
    130                 135                 140                 


Leu Arg Arg Lys Gly Asn Arg Lys Arg Asn Ser Phe Glu Ser Gln Asp 
145                 150                 155                 160 


Val Pro Thr Asn Lys Lys Gly Ser Pro Leu Thr Ser Ala Ser Gln Val 
                165                 170                 175     


Leu Thr Thr Glu Lys Glu Lys Ser Tyr Thr Gly Ile Tyr Asp Lys Ala 
            180                 185                 190         


Arg Lys Lys Lys Thr Thr Ser Asn Thr Pro Pro Ile Thr Gly Ala Ile 
        195                 200                 205             


Tyr Lys Glu His Lys Pro Leu Val Leu Arg Pro Val Tyr Ile Gly Thr 
    210                 215                 220                 


Val Gln Tyr Lys Ile Lys Met Phe Asn Ser Val Lys Glu Glu Leu Ile 
225                 230                 235                 240 


Pro Leu Gln Phe Tyr Gly Thr Leu Pro Lys Gly Tyr Val Ile Lys Glu 
                245                 250                 255     


Ile His Tyr Arg Lys Gly Lys Asp Ala Ser Ile Ser Leu Glu Pro Asp 
            260                 265                 270         


Leu Asp Asn Ser Gly Ser Asn Thr Val Ser Lys Thr Arg Lys Leu Val 
        275                 280                 285             


Ala Gln Ser Ile Glu Asp Lys Val Lys Glu Val Phe Pro Pro Trp Arg 
    290                 295                 300                 


Gly Ala Leu Ser Lys Gly Ser Glu Ser Leu Thr Leu Met Phe Ser His 
305                 310                 315                 320 


Glu Asp Gln Lys Lys Ile Tyr Ala Asp Ser Pro Leu Asn Ala Thr Ser 
                325                 330                 335     


Ala Leu Glu His Thr Val Pro Ser Tyr Ser Ser Ser Gly Arg Ala Glu 
            340                 345                 350         


Gln Gly Ile Gln Leu Arg His Ser Gln Ser Val Pro Gln Gln Pro Glu 
        355                 360                 365             


Asp Glu Ala Lys Pro His Glu Val Glu Pro Pro Ser Val Thr Pro Asp 
    370                 375                 380                 


Thr Pro Ala Thr Met Phe Leu Arg Thr Thr Lys Glu Glu Cys Glu Leu 
385                 390                 395                 400 


Ala Ser Pro Gly Thr Ala Ala Ser Glu Asn Asp Ser Ser Val Ser Pro 
                405                 410                 415     


Ser Phe Ala Asn Glu Val Lys Lys Glu Asp Val Tyr Ser Ala His His 
            420                 425                 430         


Ser Ile Ser Leu Glu Ala Ala Ser Pro Gly Leu Ala Ala Ser Thr Gln 
        435                 440                 445             


Asp Gly Leu Asp Pro Asp Gln Glu Gln Pro Asp Leu Thr Ser Ile Glu 
    450                 455                 460                 


Arg Ala Glu Pro Val Ser Ala Lys Leu Thr Pro Thr His Pro Ser Val 
465                 470                 475                 480 


Lys Gly Glu Lys Glu Glu Asn Met Leu Glu Pro Ser Ile Ser Leu Ser 
                485                 490                 495     


Glu Pro Leu Met Leu Glu Glu Pro Glu Lys Glu Glu Ile Glu Thr Ser 
            500                 505                 510         


Leu Pro Ile Ala Ile Thr Pro Glu Pro Glu Asp Ser Asn Leu Val Glu 
        515                 520                 525             


Glu Glu Ile Val Glu Leu Asp Tyr Pro Glu Ser Pro Leu Val Ser Glu 
    530                 535                 540                 


Lys Pro Phe Pro Pro His Met Ser Pro Glu Val Glu His Lys Glu Glu 
545                 550                 555                 560 


Glu Leu Ile Leu Pro Leu Leu Ala Ala Ser Ser Pro Glu His Val Ala 
                565                 570                 575     


Leu Ser Glu Glu Glu Arg Glu Glu Ile Ala Ser Val Ser Thr Gly Ser 
            580                 585                 590         


Ala Phe Val Ser Glu Tyr Ser Val Pro Gln Asp Leu Asn His Glu Leu 
        595                 600                 605             


Gln Glu Gln Glu Gly Glu Pro Val Pro Pro Ser Asn Val Glu Ala Ile 
    610                 615                 620                 


Ala Glu His Ala Val Leu Ser Glu Glu Glu Asn Glu Glu Phe Glu Ala 
625                 630                 635                 640 


Tyr Ser Pro Ala Ala Ala Pro Thr Ser Glu Ser Ser Leu Ser Pro Ser 
                645                 650                 655     


Thr Thr Glu Lys Thr Ser Glu Asn Gln Ser Pro Leu Phe Ser Thr Val 
            660                 665                 670         


Thr Pro Glu Tyr Met Val Leu Ser Gly Asp Glu Ala Ser Glu Ser Gly 
        675                 680                 685             


Cys Tyr Thr Pro Asp Ser Thr Ser Ala Ser Glu Tyr Ser Val Pro Ser 
    690                 695                 700                 


Leu Ala Thr Lys Glu Ser Leu Lys Lys Thr Ile Asp Arg Lys Ser Pro 
705                 710                 715                 720 


Leu Ile Leu Lys Gly Val Ser Glu Tyr Met Ile Pro Ser Glu Glu Lys 
                725                 730                 735     


Glu Asp Thr Gly Ser Phe Thr Pro Ala Val Ala Pro Ala Ser Glu Pro 
            740                 745                 750         


Ser Leu Ser Pro Ser Thr Thr Glu Lys Thr Ser Glu Cys Gln Ser Pro 
        755                 760                 765             


Leu Pro Ser Thr Ala Thr Ser Glu His Val Val Pro Ser Glu Gly Glu 
    770                 775                 780                 


Asp Leu Gly Ser Glu Arg Phe Thr Pro Asp Ser Lys Leu Ile Ser Lys 
785                 790                 795                 800 


Tyr Ala Ala Pro Leu Asn Ala Thr Gln Glu Ser Gln Lys Lys Ile Ile 
                805                 810                 815     


Asn Glu Ala Ser Gln Phe Lys Pro Lys Gly Ile Ser Glu His Thr Val 
            820                 825                 830         


Leu Ser Val Asp Gly Lys Glu Val Ile Gly Pro Ser Ser Pro Asp Leu 
        835                 840                 845             


Val Val Ala Ser Glu His Ser Phe Pro Pro His Thr Thr Glu Met Thr 
    850                 855                 860                 


Ser Glu Cys Gln Ala Pro Pro Leu Ser Ala Thr Pro Ser Glu Tyr Val 
865                 870                 875                 880 


Val Leu Ser Asp Glu Glu Ala Val Glu Leu Glu Arg Tyr Thr Pro Ser 
                885                 890                 895     


Ser Thr Ser Ala Ser Glu Phe Ser Val Pro Pro Tyr Ala Thr Pro Glu 
            900                 905                 910         


Ala Gln Glu Glu Glu Ile Val His Arg Ser Leu Asn Leu Lys Gly Ala 
        915                 920                 925             


Ser Ser Pro Met Asn Leu Ser Glu Glu Asp Gln Glu Asp Ile Gly Pro 
    930                 935                 940                 


Phe Ser Pro Asp Ser Ala Phe Val Ser Glu Phe Ser Phe Pro Pro Tyr 
945                 950                 955                 960 


Ala Thr Gln Glu Ala Glu Lys Arg Glu Phe Glu Cys Asp Ser Pro Ile 
                965                 970                 975     


Cys Leu Thr Ser Pro Ser Glu His Thr Ile Leu Ser Asp Glu Asp Thr 
            980                 985                 990         


Glu Glu Ala Glu Leu Phe Ser Pro  Asp Ser Ala Ser Gln  Val Ser Ile 
        995                 1000                 1005             


Pro Pro  Phe Arg Ile Ser Glu  Thr Glu Lys Asn Glu  Leu Glu Pro 
    1010                 1015                 1020             


Asp Ser  Leu Leu Thr Ala Val  Ser Ala Ser Gly Tyr  Ser Cys Phe 
    1025                 1030                 1035             


Ser Glu  Ala Asp Glu Glu Asp  Ile Gly Ser Thr Ala  Ala Thr Pro 
    1040                 1045                 1050             


Val Ser  Glu Gln Phe Ser Ser  Ser Gln Lys Gln Lys  Ala Glu Thr 
    1055                 1060                 1065             


Phe Pro  Leu Met Ser Pro Leu  Glu Asp Leu Ser Leu  Pro Pro Ser 
    1070                 1075                 1080             


Thr Asp  Lys Ser Glu Lys Ala  Glu Ile Lys Pro Glu  Ile Pro Thr 
    1085                 1090                 1095             


Thr Ser  Thr Ser Val Ser Glu  Tyr Leu Ile Leu Ala  Gln Lys Gln 
    1100                 1105                 1110             


Lys Thr  Gln Ala Tyr Leu Glu  Pro Glu Ser Glu Asp  Leu Ile Pro 
    1115                 1120                 1125             


Ser His  Leu Thr Ser Glu Val  Glu Lys Gly Glu Arg  Glu Ala Ser 
    1130                 1135                 1140             


Ser Ser  Val Ala Ala Ile Pro  Ala Ala Leu Pro Ala  Gln Ser Ser 
    1145                 1150                 1155             


Ile Val  Lys Glu Glu Thr Lys  Pro Ala Ser Pro His  Ser Val Leu 
    1160                 1165                 1170             


Pro Asp  Ser Val Pro Ala Ile  Lys Lys Glu Gln Glu  Pro Thr Ala 
    1175                 1180                 1185             


Ala Leu  Thr Leu Lys Ala Ala  Asp Glu Gln Met Ala  Leu Ser Lys 
    1190                 1195                 1200             


Val Arg  Lys Glu Glu Ile Val  Pro Asp Ser Gln Glu  Ala Thr Ala 
    1205                 1210                 1215             


His Val  Ser Gln Asp Gln Lys  Met Glu Pro Gln Pro  Pro Asn Val 
    1220                 1225                 1230             


Pro Glu  Ser Glu Met Lys Tyr  Ser Val Leu Pro Asp  Met Val Asp 
    1235                 1240                 1245             


Glu Pro  Lys Lys Gly Val Lys  Pro Lys Leu Val Leu  Asn Val Thr 
    1250                 1255                 1260             


Ser Glu  Leu Glu Gln Arg Lys  Leu Ser Lys Asn Glu  Pro Glu Val 
    1265                 1270                 1275             


Ile Lys  Pro Tyr Ser Pro Leu  Lys Glu Thr Ser Leu  Ser Gly Pro 
    1280                 1285                 1290             


Glu Ala  Leu Ser Ala Val Lys  Met Glu Met Lys His  Asp Ser Lys 
    1295                 1300                 1305             


Ile Thr  Thr Thr Pro Ile Val  Leu His Ser Ala Ser  Ser Gly Val 
    1310                 1315                 1320             


Glu Lys  Gln Val Glu His Gly  Pro Pro Ala Leu Ala  Phe Ser Ala 
    1325                 1330                 1335             


Leu Ser  Glu Glu Ile Lys Lys  Glu Ile Glu Pro Ser  Ser Ser Thr 
    1340                 1345                 1350             


Thr Thr  Ala Ser Val Thr Lys  Leu Asp Ser Asn Leu  Thr Arg Ala 
    1355                 1360                 1365             


Val Lys  Glu Glu Ile Pro Thr  Asp Ser Ser Leu Ile  Thr Pro Val 
    1370                 1375                 1380             


Asp Arg  Pro Val Leu Thr Lys  Val Gly Lys Gly Glu  Leu Gly Ser 
    1385                 1390                 1395             


Gly Leu  Pro Pro Leu Val Thr  Ser Ala Asp Glu His  Ser Val Leu 
    1400                 1405                 1410             


Ala Glu  Glu Asp Lys Val Ala  Ile Lys Gly Ala Ser  Pro Ile Glu 
    1415                 1420                 1425             


Thr Ser  Ser Lys His Leu Ala  Trp Ser Glu Ala Glu  Lys Glu Ile 
    1430                 1435                 1440             


Lys Phe  Asp Ser Leu Pro Ser  Val Ser Ser Ile Ala  Glu His Ser 
    1445                 1450                 1455             


Val Leu  Ser Glu Val Glu Ala  Lys Glu Val Lys Ala  Gly Leu Pro 
    1460                 1465                 1470             


Val Ile  Lys Thr Ser Ser Ser  Gln His Ser Asp Lys  Ser Glu Glu 
    1475                 1480                 1485             


Ala Arg  Val Glu Asp Lys Gln  Asp Leu Leu Phe Ser  Thr Val Cys 
    1490                 1495                 1500             


Asp Ser  Glu Arg Leu Val Ser  Ser Gln Lys Lys Ser  Leu Met Ser 
    1505                 1510                 1515             


Thr Ser  Glu Val Leu Glu Pro  Glu His Glu Leu Pro  Leu Ser Leu 
    1520                 1525                 1530             


Trp Gly  Glu Ile Lys Lys Lys  Glu Thr Glu Leu Pro  Ser Ser Gln 
    1535                 1540                 1545             


Asn Val  Ser Pro Ala Ser Lys  His Ile Ile Pro Lys  Gly Lys Asp 
    1550                 1555                 1560             


Glu Glu  Thr Ala Ser Ser Ser  Pro Glu Leu Glu Asn  Leu Ala Ser 
    1565                 1570                 1575             


Gly Leu  Ala Pro Thr Leu Leu  Leu Leu Ser Asp Asp  Lys Asn Lys 
    1580                 1585                 1590             


Pro Ala  Val Glu Val Ser Ser  Thr Ala Gln Gly Asp  Phe Pro Ser 
    1595                 1600                 1605             


Glu Lys  Gln Asp Val Ala Leu  Ala Glu Leu Ser Leu  Glu Pro Glu 
    1610                 1615                 1620             


Lys Lys  Asp Lys Pro His Gln  Pro Leu Glu Leu Pro  Asn Ala Gly 
    1625                 1630                 1635             


Ser Glu  Phe Ser Ser Asp Leu  Gly Arg Gln Ser Gly  Ser Ile Gly 
    1640                 1645                 1650             


Thr Lys  Gln Ala Lys Ser Pro  Ile Thr Glu Thr Glu  Asp Ser Val 
    1655                 1660                 1665             


Leu Glu  Lys Gly Pro Ala Glu  Leu Arg Ser Arg Glu  Gly Lys Glu 
    1670                 1675                 1680             


Glu Asn  Arg Glu Leu Cys Ala  Ser Ser Thr Met Pro  Ala Ile Ser 
    1685                 1690                 1695             


Glu Leu  Ser Ser Leu Leu Arg  Glu Glu Ser Gln Asn  Glu Glu Ile 
    1700                 1705                 1710             


Lys Pro  Phe Ser Pro Lys Ile  Ile Ser Leu Glu Ser  Lys Glu Pro 
    1715                 1720                 1725             


Pro Ala  Ser Val Ala Glu Gly  Gly Asn Pro Glu Glu  Phe Gln Pro 
    1730                 1735                 1740             


Phe Thr  Phe Ser Leu Lys Gly  Leu Ser Glu Glu Val  Ser His Pro 
    1745                 1750                 1755             


Ala Asp  Phe Lys Lys Gly Gly  Asn Gln Glu Ile Gly  Pro Leu Pro 
    1760                 1765                 1770             


Pro Thr  Gly Asn Leu Lys Ala  Gln Val Met Gly Asp  Ile Leu Asp 
    1775                 1780                 1785             


Lys Leu  Ser Glu Glu Thr Gly  His Pro Asn Ser Ser  Gln Val Leu 
    1790                 1795                 1800             


Gln Ser  Ile Thr Glu Pro Ser  Lys Ile Ala Pro Ser  Asp Leu Leu 
    1805                 1810                 1815             


Val Glu  Gln Lys Lys Thr Glu  Lys Ala Leu His Ser  Asp Gln Thr 
    1820                 1825                 1830             


Val Lys  Leu Pro Asp Val Ser  Thr Ser Ser Glu Asp  Lys Gln Asp 
    1835                 1840                 1845             


Leu Gly  Ile Lys Gln Phe Ser  Leu Met Arg Glu Asn  Leu Pro Leu 
    1850                 1855                 1860             


Glu Gln  Ser Lys Ser Phe Met  Thr Thr Lys Pro Ala  Asp Val Lys 
    1865                 1870                 1875             


Glu Thr  Lys Met Glu Glu Phe  Phe Ile Ser Pro Lys  Asp Glu Asn 
    1880                 1885                 1890             


Trp Met  Leu Gly Lys Pro Glu  Asn Val Ala Ser Gln  His Glu Gln 
    1895                 1900                 1905             


Arg Ile  Ala Gly Ser Val Gln  Leu Asp Ser Ser Ser  Ser Asn Glu 
    1910                 1915                 1920             


Leu Arg  Pro Gly Gln Leu Lys  Ala Ala Val Ser Ser  Lys Asp His 
    1925                 1930                 1935             


Thr Cys  Glu Val Arg Lys Gln  Val Leu Pro His Ser  Ala Glu Glu 
    1940                 1945                 1950             


Ser His  Leu Ser Ser Gln Glu  Ala Val Ser Ala Leu  Asp Thr Ser 
    1955                 1960                 1965             


Ser Gly  Asn Thr Glu Thr Leu  Ser Ser Lys Ser Tyr  Ser Ser Glu 
    1970                 1975                 1980             


Glu Val  Lys Leu Ala Glu Glu  Pro Lys Ser Leu Val  Leu Ala Gly 
    1985                 1990                 1995             


Asn Val  Glu Arg Asn Ile Ala  Glu Gly Lys Glu Ile  His Ser Leu 
    2000                 2005                 2010             


Met Glu  Ser Glu Ser Leu Leu  Leu Glu Lys Ala Asn  Thr Glu Leu 
    2015                 2020                 2025             


Ser Trp  Pro Ser Lys Glu Asp  Ser Gln Glu Lys Ile  Lys Leu Pro 
    2030                 2035                 2040             


Pro Glu  Arg Phe Phe Gln Lys  Pro Val Ser Gly Leu  Ser Val Glu 
    2045                 2050                 2055             


Gln Val  Lys Ser Glu Thr Ile  Ser Ser Ser Val Lys  Thr Ala His 
    2060                 2065                 2070             


Phe Pro  Ala Glu Gly Val Glu  Pro Ala Leu Gly Asn  Glu Lys Glu 
    2075                 2080                 2085             


Ala His  Arg Ser Thr Pro Pro  Phe Pro Glu Glu Lys  Pro Leu Glu 
    2090                 2095                 2100             


Glu Ser  Lys Met Val Gln Ser  Lys Val Ile Asp Asp  Ala Asp Glu 
    2105                 2110                 2115             


Gly Lys  Lys Pro Ser Pro Glu  Val Lys Ile Pro Thr  Gln Arg Lys 
    2120                 2125                 2130             


Pro Ile  Ser Ser Ile His Ala  Arg Glu Pro Gln Ser  Pro Glu Ser 
    2135                 2140                 2145             


Pro Glu  Val Thr Gln Asn Pro  Pro Thr Gln Pro Lys  Val Ala Lys 
    2150                 2155                 2160             


Pro Asp  Leu Pro Glu Glu Lys  Gly Lys Lys Gly Ile  Ser Ser Phe 
    2165                 2170                 2175             


Lys Ser  Trp Met Ser Ser Leu  Phe Phe Gly Ser Ser  Thr Pro Asp 
    2180                 2185                 2190             


Asn Lys  Val Ala Glu Gln Glu  Asp Leu Glu Thr Gln  Pro Ser Pro 
    2195                 2200                 2205             


Ser Val  Glu Lys Ala Val Thr  Val Ile Asp Pro Glu  Gly Thr Ile 
    2210                 2215                 2220             


Pro Thr  Asn Phe Asn Val Ala  Glu Lys Pro Ala Asp  His Ser Leu 
    2225                 2230                 2235             


Ser Glu  Val Lys Leu Lys Thr  Ala Asp Glu Pro Arg  Gly Thr Leu 
    2240                 2245                 2250             


Val Lys  Ser Gly Asp Gly Gln  Asn Val Lys Glu Lys  Ser Met Ile 
    2255                 2260                 2265             


Leu Ser  Asn Val Glu Asp Leu  Gln Gln Pro Lys Phe  Ile Ser Glu 
    2270                 2275                 2280             


Val Ser  Arg Glu Asp Tyr Gly  Lys Lys Glu Ile Ser  Gly Asp Ser 
    2285                 2290                 2295             


Glu Glu  Met Asn Ile Asn Ser  Val Val Thr Ser Ala  Asp Gly Glu 
    2300                 2305                 2310             


Asn Leu  Glu Ile Gln Ser Tyr  Ser Leu Ile Gly Glu  Lys Leu Val 
    2315                 2320                 2325             


Met Glu  Glu Ala Lys Thr Ile  Val Pro Pro His Val  Thr Asp Ser 
    2330                 2335                 2340             


Lys Arg  Val Gln Lys Pro Ala  Ile Ala Pro Pro Ser  Lys Trp Asn 
    2345                 2350                 2355             


Ile Ser  Ile Phe Lys Glu Glu  Pro Arg Ser Asp Gln  Lys Gln Lys 
    2360                 2365                 2370             


Ser Leu  Leu Ser Phe Asp Val  Val Asp Lys Val Pro  Gln Gln Pro 
    2375                 2380                 2385             


Lys Ser  Ala Ser Ser Asn Phe  Ala Ser Lys Asn Ile  Thr Lys Glu 
    2390                 2395                 2400             


Ser Glu  Lys Pro Glu Ser Ile  Ile Leu Pro Val Glu  Glu Ser Lys 
    2405                 2410                 2415             


Gly Ser  Leu Ile Asp Phe Ser  Glu Asp Arg Leu Lys  Lys Glu Met 
    2420                 2425                 2430             


Gln Asn  Pro Thr Ser Leu Lys  Ile Ser Glu Glu Glu  Thr Lys Leu 
    2435                 2440                 2445             


Arg Ser  Val Ser Pro Thr Glu  Lys Lys Asp Asn Leu  Glu Asn Arg 
    2450                 2455                 2460             


Ser Tyr  Thr Leu Ala Glu Lys  Lys Val Leu Ala Glu  Lys Gln Asn 
    2465                 2470                 2475             


Ser Val  Ala Pro Leu Glu Leu  Arg Asp Ser Asn Glu  Ile Gly Lys 
    2480                 2485                 2490             


Thr Gln  Ile Thr Leu Gly Ser  Arg Ser Thr Glu Leu  Lys Glu Ser 
    2495                 2500                 2505             


Lys Ala  Asp Ala Met Pro Gln  His Phe Tyr Gln Asn  Glu Asp Tyr 
    2510                 2515                 2520             


Asn Glu  Arg Pro Lys Ile Ile  Val Gly Ser Glu Lys  Glu Lys Gly 
    2525                 2530                 2535             


Glu Glu  Lys Glu Asn Gln Val  Tyr Val Leu Ser Glu  Gly Lys Lys 
    2540                 2545                 2550             


Gln Gln  Glu His Gln Pro Tyr  Ser Val Asn Val Ala  Glu Ser Met 
    2555                 2560                 2565             


Ser Arg  Glu Ser Asp Ile Ser  Leu Gly His Ser Leu  Gly Glu Thr 
    2570                 2575                 2580             


Gln Ser  Phe Ser Leu Val Lys  Ala Thr Ser Val Thr  Glu Lys Ser 
    2585                 2590                 2595             


Glu Ala  Met Leu Ala Glu Ala  His Pro Glu Ile Arg  Glu Ala Lys 
    2600                 2605                 2610             


Ala Val  Gly Thr Gln Pro His  Pro Leu Glu Glu Ser  Lys Val Leu 
    2615                 2620                 2625             


Val Glu  Lys Thr Lys Thr Phe  Leu Pro Val Ala Leu  Ser Cys Arg 
    2630                 2635                 2640             


Asp Glu  Ile Glu Asn His Ser  Leu Ser Gln Glu Gly  Asn Leu Val 
    2645                 2650                 2655             


Leu Glu  Lys Ser Ser Arg Asp  Met Pro Asp His Ser  Glu Glu Lys 
    2660                 2665                 2670             


Glu Gln  Phe Arg Glu Ser Glu  Leu Ser Lys Gly Gly  Ser Val Asp 
    2675                 2680                 2685             


Ile Thr  Lys Glu Thr Val Lys  Gln Gly Phe Gln Glu  Lys Ala Val 
    2690                 2695                 2700             


Gly Thr  Gln Pro Arg Pro Leu  Glu Glu Ser Lys Val  Leu Val Glu 
    2705                 2710                 2715             


Lys Thr  Lys Thr Phe Leu Pro  Val Val Leu Ser Cys  His Asp Glu 
    2720                 2725                 2730             


Ile Glu  Asn His Ser Leu Ser  Gln Glu Gly Asn Leu  Val Leu Glu 
    2735                 2740                 2745             


Lys Ser  Ser Arg Asp Met Pro  Asp His Ser Glu Glu  Lys Glu Gln 
    2750                 2755                 2760             


Phe Lys  Glu Ser Glu Leu Trp  Lys Gly Gly Ser Val  Asp Ile Thr 
    2765                 2770                 2775             


Lys Glu  Ser Met Lys Glu Gly  Phe Pro Ser Lys Glu  Ser Glu Arg 
    2780                 2785                 2790             


Thr Leu  Ala Arg Pro Phe Asp  Glu Thr Lys Ser Ser  Glu Thr Pro 
    2795                 2800                 2805             


Pro Tyr  Leu Leu Ser Pro Val  Lys Pro Gln Thr Leu  Ala Ser Gly 
    2810                 2815                 2820             


Ala Ser  Pro Glu Ile Asn Ala  Val Lys Lys Lys Glu  Met Pro Arg 
    2825                 2830                 2835             


Ser Glu  Leu Thr Pro Glu Arg  His Thr Val His Thr  Ile Gln Thr 
    2840                 2845                 2850             


Ser Lys  Asp Asp Thr Ser Asp  Val Pro Lys Gln Ser  Val Leu Val 
    2855                 2860                 2865             


Ser Lys  His His Leu Glu Ala  Ala Glu Asp Thr Arg  Val Lys Glu 
    2870                 2875                 2880             


Pro Leu  Ser Ser Ala Lys Ser  Asn Tyr Ala Gln Phe  Ile Ser Asn 
    2885                 2890                 2895             


Thr Ser  Ala Ser Asn Ala Asp  Lys Met Val Ser Asn  Lys Glu Met 
    2900                 2905                 2910             


Pro Lys  Glu Pro Glu Asp Thr  Tyr Ala Lys Gly Glu  Asp Phe Thr 
    2915                 2920                 2925             


Val Thr  Ser Lys Pro Ala Gly  Leu Ser Glu Asp Gln  Lys Thr Ala 
    2930                 2935                 2940             


Phe Ser  Ile Ile Ser Glu Gly  Cys Glu Ile Leu Asn  Ile His Ala 
    2945                 2950                 2955             


Pro Ala  Phe Ile Ser Ser Ile  Asp Gln Glu Glu Ser  Glu Gln Met 
    2960                 2965                 2970             


Gln Asp  Lys Leu Glu Tyr Leu  Glu Glu Lys Ala Ser  Phe Lys Thr 
    2975                 2980                 2985             


Ile Pro  Leu Pro Asp Asp Ser  Glu Thr Val Ala Cys  His Lys Thr 
    2990                 2995                 3000             


Leu Lys  Ser Arg Leu Glu Asp  Glu Lys Val Thr Pro  Leu Lys Glu 
    3005                 3010                 3015             


Asn Lys  Gln Lys Glu Thr His  Lys Thr Lys Glu Glu  Ile Ser Thr 
    3020                 3025                 3030             


Asp Ser  Glu Thr Asp Leu Ser  Phe Ile Gln Pro Thr  Ile Pro Ser 
    3035                 3040                 3045             


Glu Glu  Asp Tyr Phe Glu Lys  Tyr Thr Leu Ile Asp  Tyr Asn Ile 
    3050                 3055                 3060             


Ser Pro  Asp Pro Glu Lys Gln  Lys Ala Pro Gln Lys  Leu Asn Val 
    3065                 3070                 3075             


Glu Glu  Lys Leu Ser Lys Glu  Val Thr Glu Glu Thr  Ile Ser Phe 
    3080                 3085                 3090             


Pro Val  Ser Ser Val Glu Ser  Ala Leu Glu His Glu  Tyr Asp Leu 
    3095                 3100                 3105             


Val Lys  Leu Asp Glu Ser Phe  Tyr Gly Pro Glu Lys  Gly His Asn 
    3110                 3115                 3120             


Ile Leu  Ser His Pro Glu Thr  Gln Ser Gln Asn Ser  Ala Asp Arg 
    3125                 3130                 3135             


Asn Val  Ser Lys Asp Thr Lys  Arg Asp Val Asp Ser  Lys Ser Pro 
    3140                 3145                 3150             


Gly Met  Pro Leu Phe Glu Ala  Glu Glu Gly Val Leu  Ser Arg Thr 
    3155                 3160                 3165             


Gln Ile  Phe Pro Thr Thr Ile  Lys Val Ile Asp Pro  Glu Phe Leu 
    3170                 3175                 3180             


Glu Glu  Pro Pro Ala Leu Ala  Phe Leu Tyr Lys Asp  Leu Tyr Glu 
    3185                 3190                 3195             


Glu Ala  Val Gly Glu Lys Lys  Lys Glu Glu Glu Thr  Ala Ser Glu 
    3200                 3205                 3210             


Gly Asp  Ser Val Asn Ser Glu  Ala Ser Phe Pro Ser  Arg Asn Ser 
    3215                 3220                 3225             


Asp Thr  Asp Asp Gly Thr Gly  Ile Tyr Phe Glu Lys  Tyr Ile Leu 
    3230                 3235                 3240             


Lys Asp  Asp Ile Leu His Asp  Thr Ser Leu Thr Gln  Lys Asp Gln 
    3245                 3250                 3255             


Gly Gln  Gly Leu Glu Glu Lys  Arg Val Gly Lys Asp  Asp Ser Tyr 
    3260                 3265                 3270             


Gln Pro  Ile Ala Ala Glu Gly  Glu Ile Trp Gly Lys  Phe Gly Thr 
    3275                 3280                 3285             


Ile Cys  Arg Glu Lys Ser Leu  Glu Glu Gln Lys Gly  Val Tyr Gly 
    3290                 3295                 3300             


Glu Gly  Glu Ser Val Asp His  Val Glu Thr Val Gly  Asn Val Ala 
    3305                 3310                 3315             


Met Gln  Lys Lys Ala Pro Ile  Thr Glu Asp Val Arg  Val Ala Thr 
    3320                 3325                 3330             


Gln Lys  Ile Ser Tyr Ala Val  Pro Phe Glu Asp Thr  His His Val 
    3335                 3340                 3345             


Leu Glu  Arg Ala Asp Glu Ala  Gly Ser His Gly Asn  Glu Val Gly 
    3350                 3355                 3360             


Asn Ala  Ser Pro Glu Val Asn  Leu Asn Val Pro Val  Gln Val Ser 
    3365                 3370                 3375             


Phe Pro  Glu Glu Glu Phe Ala  Ser Gly Ala Thr His  Val Gln Glu 
    3380                 3385                 3390             


Thr Ser  Leu Glu Glu Pro Lys  Ile Leu Val Pro Pro  Glu Pro Ser 
    3395                 3400                 3405             


Glu Glu  Arg Leu Arg Asn Ser  Pro Val Gln Asp Glu  Tyr Glu Phe 
    3410                 3415                 3420             


Thr Glu  Ser Leu His Asn Glu  Val Val Pro Gln Asp  Ile Leu Ser 
    3425                 3430                 3435             


Glu Glu  Leu Ser Ser Glu Ser  Thr Pro Glu Asp Val  Leu Ser Gln 
    3440                 3445                 3450             


Gly Lys  Glu Ser Phe Glu His  Ile Ser Glu Asn Glu  Phe Ala Ser 
    3455                 3460                 3465             


Glu Ala  Glu Gln Ser Thr Pro  Ala Glu Gln Lys Glu  Leu Gly Ser 
    3470                 3475                 3480             


Glu Arg  Lys Glu Glu Asp Gln  Leu Ser Ser Glu Val  Val Thr Glu 
    3485                 3490                 3495             


Lys Ala  Gln Lys Glu Leu Lys  Lys Ser Gln Ile Asp  Thr Tyr Cys 
    3500                 3505                 3510             


Tyr Thr  Cys Lys Cys Pro Ile  Ser Ala Thr Asp Lys  Val Phe Gly 
    3515                 3520                 3525             


Thr His  Lys Asp His Glu Val  Ser Thr Leu Asp Thr  Ala Ile Ser 
    3530                 3535                 3540             


Ala Val  Lys Val Gln Leu Ala  Glu Phe Leu Glu Asn  Leu Gln Glu 
    3545                 3550                 3555             


Lys Ser  Leu Arg Ile Glu Ala  Phe Val Ser Glu Ile  Glu Ser Phe 
    3560                 3565                 3570             


Phe Asn  Thr Ile Glu Glu Asn  Cys Ser Lys Asn Glu  Lys Arg Leu 
    3575                 3580                 3585             


Glu Glu  Gln Asn Glu Glu Met  Met Lys Lys Val Leu  Ala Gln Tyr 
    3590                 3595                 3600             


Asp Glu  Lys Ala Gln Ser Phe  Glu Glu Val Lys Lys  Lys Lys Met 
    3605                 3610                 3615             


Glu Phe  Leu His Glu Gln Met  Val His Phe Leu Gln  Ser Met Asp 
    3620                 3625                 3630             


Thr Ala  Lys Asp Thr Leu Glu  Thr Ile Val Arg Glu  Ala Glu Glu 
    3635                 3640                 3645             


Leu Asp  Glu Ala Val Phe Leu  Thr Ser Phe Glu Glu  Ile Asn Glu 
    3650                 3655                 3660             


Arg Leu  Leu Ser Ala Met Glu  Ser Thr Ala Ser Leu  Glu Lys Met 
    3665                 3670                 3675             


Pro Ala  Ala Phe Ser Leu Phe  Glu His Tyr Asp Asp  Ser Ser Ala 
    3680                 3685                 3690             


Arg Ser  Asp Gln Met Leu Lys  Gln Val Ala Val Pro  Gln Pro Pro 
    3695                 3700                 3705             


Arg Leu  Glu Pro Gln Glu Pro  Asn Ser Ala Thr Ser  Thr Thr Ile 
    3710                 3715                 3720             


Ala Val  Tyr Trp Ser Met Asn  Lys Glu Asp Val Ile  Asp Ser Phe 
    3725                 3730                 3735             


Gln Val  Tyr Cys Met Glu Glu  Pro Gln Asp Asp Gln  Glu Val Asn 
    3740                 3745                 3750             


Glu Leu  Val Glu Glu Tyr Arg  Leu Thr Val Lys Glu  Ser Tyr Cys 
    3755                 3760                 3765             


Ile Phe  Glu Asp Leu Glu Pro  Asp Arg Cys Tyr Gln  Val Trp Val 
    3770                 3775                 3780             


Met Ala  Val Asn Phe Thr Gly  Cys Ser Leu Pro Ser  Glu Arg Ala 
    3785                 3790                 3795             


Ile Phe  Arg Thr Ala Pro Ser  Thr Pro Val Ile Arg  Ala Glu Asp 
    3800                 3805                 3810             


Cys Thr  Val Cys Trp Asn Thr  Ala Thr Ile Arg Trp  Arg Pro Thr 
    3815                 3820                 3825             


Thr Pro  Glu Ala Thr Glu Thr  Tyr Thr Leu Glu Tyr  Cys Arg Gln 
    3830                 3835                 3840             


His Ser  Pro Glu Gly Glu Gly  Leu Arg Ser Phe Ser  Gly Ile Lys 
    3845                 3850                 3855             


Gly Leu  Gln Leu Lys Val Asn  Leu Gln Pro Asn Asp  Asn Tyr Phe 
    3860                 3865                 3870             


Phe Tyr  Val Arg Ala Ile Asn  Ala Phe Gly Thr Ser  Glu Gln Ser 
    3875                 3880                 3885             


Glu Ala  Ala Leu Ile Ser Thr  Arg Gly Thr Arg Phe  Leu Leu Leu 
    3890                 3895                 3900             


Arg Glu  Thr Ala His Pro Ala  Leu His Ile Ser Ser  Ser Gly Thr 
    3905                 3910                 3915             


Val Ile  Ser Phe Gly Glu Arg  Arg Arg Leu Thr Glu  Ile Pro Ser 
    3920                 3925                 3930             


Val Leu  Gly Glu Glu Leu Pro  Ser Cys Gly Gln His  Tyr Trp Glu 
    3935                 3940                 3945             


Thr Thr  Val Thr Asp Cys Pro  Ala Tyr Arg Leu Gly  Ile Cys Ser 
    3950                 3955                 3960             


Ser Ser  Ala Val Gln Ala Gly  Ala Leu Gly Gln Gly  Glu Thr Ser 
    3965                 3970                 3975             


Trp Tyr  Met His Cys Ser Glu  Pro Gln Arg Tyr Thr  Phe Phe Tyr 
    3980                 3985                 3990             


Ser Gly  Ile Val Ser Asp Val  His Val Thr Glu Arg  Pro Ala Arg 
    3995                 4000                 4005             


Val Gly  Ile Leu Leu Asp Tyr  Asn Asn Gln Arg Leu  Ile Phe Ile 
    4010                 4015                 4020             


Asn Ala  Glu Ser Glu Gln Leu  Leu Phe Ile Ile Arg  His Arg Phe 
    4025                 4030                 4035             


Asn Glu  Gly Val His Pro Ala  Phe Ala Leu Glu Lys  Pro Gly Lys 
    4040                 4045                 4050             


Cys Thr  Leu His Leu Gly Ile  Glu Pro Pro Asp Ser  Val Arg His 
    4055                 4060                 4065             


Lys 
    


<210>  2330
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNBD1__Homo_sapiens__NP_775809

<400>  2330

Met Pro Met Ser Ser Leu Pro Ala Ala Ile Leu Ser His Met Thr Ala 
1               5                   10                  15      


Ile Asn Asn Val Pro Pro Pro Pro Leu His Ser Ile Pro Asn Leu Lys 
            20                  25                  30          


Lys Ser Lys His Ile Asn Tyr Gly Gln Leu Asn Ala Leu Cys His Ile 
        35                  40                  45              


Arg Gly Gln His Ser Arg Ser Met Ser Asn Ile Leu Ser Ala His Asp 
    50                  55                  60                  


Thr Phe Met Lys Gln Tyr Pro Lys Val Phe Leu His Gln Lys Pro Arg 
65                  70                  75                  80  


Leu Pro Lys Leu Phe Lys Gln Glu Glu Gln Arg Glu Leu Asn Glu Gly 
                85                  90                  95      


Lys Glu Glu Ser Gln His Gln Gln Pro Asp Asp Ser Asn Asn Ile Ala 
            100                 105                 110         


Val His Val Gln Arg Ala His Gly Gly His Ile Leu Tyr Arg Pro Lys 
        115                 120                 125             


Arg Ala Thr Glu Lys Phe Glu Glu Phe Leu Ala Ile Leu Lys Lys Leu 
    130                 135                 140                 


Pro Ile His Arg Thr Pro Tyr Glu His Lys Thr Val Trp Lys Phe Leu 
145                 150                 155                 160 


Lys Thr Ile Pro Asp Leu Thr Phe Gln Leu Asn Asp Lys His Leu Lys 
                165                 170                 175     


Thr Leu Ser Lys Thr Val Phe Ser Glu Thr Trp Leu Lys Gly Ser Thr 
            180                 185                 190         


Val Val Ala Asn Asp Gly Phe Tyr Val Ile Leu Lys Gly Leu Ala Arg 
        195                 200                 205             


Pro Gln Thr Asn Val Tyr Lys Asn Leu Ile Glu Gly Ser Asp Ser Pro 
    210                 215                 220                 


Asp Ser Phe Ile Ser Gln Ser Phe His Ser Phe Ile Trp Ser Glu Glu 
225                 230                 235                 240 


Phe Lys Asn Ser Thr Leu Ala Glu Met Tyr Leu Pro Ser Tyr Asp Ser 
                245                 250                 255     


Met Leu Ser Lys Trp Ser Thr Phe Gly Thr Leu Glu Val Met Pro Gln 
            260                 265                 270         


Asn Glu Ser Glu Thr Gln Met Phe Ser Val Val Thr Glu Asp Asp Cys 
        275                 280                 285             


Glu Ile Leu Lys Ile Pro Ala Lys Gly Tyr Ala Lys Ile Lys Glu Glu 
    290                 295                 300                 


Lys Ile Lys Leu Glu Asn Met Gln Lys Leu Lys Leu Ile Arg Met Cys 
305                 310                 315                 320 


Pro Tyr Tyr Glu Glu Trp Pro Thr Leu Ser Ile Tyr Glu Leu Ile Ala 
                325                 330                 335     


Leu Leu Lys Trp Lys Lys Phe Pro Pro Gly His Val Ile Val Glu Ser 
            340                 345                 350         


Gly Asn Ile Ile Ser Phe Val Gly Tyr Ile Asn Ser Gly Cys Cys Asn 
        355                 360                 365             


Ile Tyr Arg Ser Ile Ile Gly Phe Val Lys Leu Arg Ser Asn Lys Val 
    370                 375                 380                 


Lys Arg Ser Gln Lys Leu Val Tyr Met Gly Lys Leu Lys Glu Lys Glu 
385                 390                 395                 400 


Ser Phe Gly Glu Ile Ser Val Leu Leu Gln Val Pro Phe Thr Cys Thr 
                405                 410                 415     


Ile Ile Thr Lys Lys Glu Val Glu Met Ala Ile Ile Glu Asp Lys Asp 
            420                 425                 430         


Leu Phe Val Ala 
        435     


<210>  2331
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNBP__Homo_sapiens__NP_001120664

<400>  2331

Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Val Glu Ala Cys Tyr Asn Cys Gly 
65                  70                  75                  80  


Arg Gly Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg 
                85                  90                  95      


Glu Gln Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp 
            100                 105                 110         


Cys Asp His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly 
        115                 120                 125             


His Ile Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu 
    130                 135                 140                 


Thr Gly His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys 
145                 150                 155                 160 


Tyr Arg Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu 
                165                 170                 175     


Ala Thr Ala 
            


<210>  2332
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNDP1__Homo_sapiens__NP_116038

<400>  2332

Met Asp Pro Lys Leu Gly Arg Met Ala Ala Ser Leu Leu Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Glu Arg Gly Met Phe Ser Ser Pro Ser Pro Pro Pro 
            20                  25                  30          


Ala Leu Leu Glu Lys Val Phe Gln Tyr Ile Asp Leu His Gln Asp Glu 
        35                  40                  45              


Phe Val Gln Thr Leu Lys Glu Trp Val Ala Ile Glu Ser Asp Ser Val 
    50                  55                  60                  


Gln Pro Val Pro Arg Phe Arg Gln Glu Leu Phe Arg Met Met Ala Val 
65                  70                  75                  80  


Ala Ala Asp Thr Leu Gln Arg Leu Gly Ala Arg Val Ala Ser Val Asp 
                85                  90                  95      


Met Gly Pro Gln Gln Leu Pro Asp Gly Gln Ser Leu Pro Ile Pro Pro 
            100                 105                 110         


Val Ile Leu Ala Glu Leu Gly Ser Asp Pro Thr Lys Gly Thr Val Cys 
        115                 120                 125             


Phe Tyr Gly His Leu Asp Val Gln Pro Ala Asp Arg Gly Asp Gly Trp 
    130                 135                 140                 


Leu Thr Asp Pro Tyr Val Leu Thr Glu Val Asp Gly Lys Leu Tyr Gly 
145                 150                 155                 160 


Arg Gly Ala Thr Asp Asn Lys Gly Pro Val Leu Ala Trp Ile Asn Ala 
                165                 170                 175     


Val Ser Ala Phe Arg Ala Leu Glu Gln Asp Leu Pro Val Asn Ile Lys 
            180                 185                 190         


Phe Ile Ile Glu Gly Met Glu Glu Ala Gly Ser Val Ala Leu Glu Glu 
        195                 200                 205             


Leu Val Glu Lys Glu Lys Asp Arg Phe Phe Ser Gly Val Asp Tyr Ile 
    210                 215                 220                 


Val Ile Ser Asp Asn Leu Trp Ile Ser Gln Arg Lys Pro Ala Ile Thr 
225                 230                 235                 240 


Tyr Gly Thr Arg Gly Asn Ser Tyr Phe Met Val Glu Val Lys Cys Arg 
                245                 250                 255     


Asp Gln Asp Phe His Ser Gly Thr Phe Gly Gly Ile Leu His Glu Pro 
            260                 265                 270         


Met Ala Asp Leu Val Ala Leu Leu Gly Ser Leu Val Asp Ser Ser Gly 
        275                 280                 285             


His Ile Leu Val Pro Gly Ile Tyr Asp Glu Val Val Pro Leu Thr Glu 
    290                 295                 300                 


Glu Glu Ile Asn Thr Tyr Lys Ala Ile His Leu Asp Leu Glu Glu Tyr 
305                 310                 315                 320 


Arg Asn Ser Ser Arg Val Glu Lys Phe Leu Phe Asp Thr Lys Glu Glu 
                325                 330                 335     


Ile Leu Met His Leu Trp Arg Tyr Pro Ser Leu Ser Ile His Gly Ile 
            340                 345                 350         


Glu Gly Ala Phe Asp Glu Pro Gly Thr Lys Thr Val Ile Pro Gly Arg 
        355                 360                 365             


Val Ile Gly Lys Phe Ser Ile Arg Leu Val Pro His Met Asn Val Ser 
    370                 375                 380                 


Ala Val Glu Lys Gln Val Thr Arg His Leu Glu Asp Val Phe Ser Lys 
385                 390                 395                 400 


Arg Asn Ser Ser Asn Lys Met Val Val Ser Met Thr Leu Gly Leu His 
                405                 410                 415     


Pro Trp Ile Ala Asn Ile Asp Asp Thr Gln Tyr Leu Ala Ala Lys Arg 
            420                 425                 430         


Ala Ile Arg Thr Val Phe Gly Thr Glu Pro Asp Met Ile Arg Asp Gly 
        435                 440                 445             


Ser Thr Ile Pro Ile Ala Lys Met Phe Gln Glu Ile Val His Lys Ser 
    450                 455                 460                 


Val Val Leu Ile Pro Leu Gly Ala Val Asp Asp Gly Glu His Ser Gln 
465                 470                 475                 480 


Asn Glu Lys Ile Asn Arg Trp Asn Tyr Ile Glu Gly Thr Lys Leu Phe 
                485                 490                 495     


Ala Ala Phe Phe Leu Glu Met Ala Gln Leu His 
            500                 505         


<210>  2333
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNDP2__Homo_sapiens__NP_001161971

<400>  2333

Met Ala Ala Leu Thr Thr Leu Phe Lys Tyr Ile Asp Glu Asn Gln Asp 
1               5                   10                  15      


Arg Tyr Ile Lys Lys Leu Ala Lys Trp Val Ala Ile Gln Ser Val Ser 
            20                  25                  30          


Ala Trp Pro Glu Lys Arg Gly Glu Ile Arg Arg Met Met Glu Val Ala 
        35                  40                  45              


Ala Ala Asp Val Lys Gln Leu Gly Gly Ser Val Glu Leu Val Asp Ile 
    50                  55                  60                  


Gly Lys Gln Lys Glu Ile Pro Val Asn Val Arg Phe Cys Leu Glu Gly 
65                  70                  75                  80  


Met Glu Glu Ser Gly Ser Glu Gly Leu Asp Glu Leu Ile Phe Ala Arg 
                85                  90                  95      


Lys Asp Thr Phe Phe Lys Asp Val Asp Tyr Val Cys Ile Ser Asp Asn 
            100                 105                 110         


Tyr Trp Leu Gly Lys Lys Lys Pro Cys Ile Thr Tyr Gly Leu Arg Gly 
        115                 120                 125             


Ile Cys Tyr Phe Phe Ile Glu Val Glu Cys Ser Asn Lys Asp Leu His 
    130                 135                 140                 


Ser Gly Val Tyr Gly Gly Ser Val His Glu Ala Met Thr Asp Leu Ile 
145                 150                 155                 160 


Leu Leu Met Gly Ser Leu Val Asp Lys Arg Gly Asn Ile Leu Ile Pro 
                165                 170                 175     


Gly Ile Asn Glu Ala Val Ala Ala Val Thr Glu Glu Glu His Lys Leu 
            180                 185                 190         


Tyr Asp Asp Ile Asp Phe Asp Ile Glu Glu Phe Ala Lys Asp Val Gly 
        195                 200                 205             


Ala Gln Ile Leu Leu His Ser His Lys Lys Asp Ile Leu Met His Arg 
    210                 215                 220                 


Trp Arg Tyr Pro Ser Leu Ser Leu His Gly Ile Glu Gly Ala Phe Ser 
225                 230                 235                 240 


Gly Ser Gly Ala Lys Thr Val Ile Pro Arg Lys Val Val Gly Lys Phe 
                245                 250                 255     


Ser Ile Arg Leu Val Pro Asn Met Thr Pro Glu Val Val Gly Glu Gln 
            260                 265                 270         


Val Thr Ser Tyr Leu Thr Lys Lys Phe Ala Glu Leu Arg Ser Pro Asn 
        275                 280                 285             


Glu Phe Lys Val Tyr Met Gly His Gly Gly Lys Pro Trp Val Ser Asp 
    290                 295                 300                 


Phe Ser His Pro His Tyr Leu Ala Gly Arg Arg Ala Met Lys Thr Val 
305                 310                 315                 320 


Phe Gly Val Glu Pro Asp Leu Thr Arg Glu Gly Gly Ser Ile Pro Val 
                325                 330                 335     


Thr Leu Thr Phe Gln Glu Ala Thr Gly Lys Asn Val Met Leu Leu Pro 
            340                 345                 350         


Val Gly Ser Ala Asp Asp Gly Ala His Ser Gln Asn Glu Lys Leu Asn 
        355                 360                 365             


Arg Tyr Asn Tyr Ile Glu Gly Thr Lys Met Leu Ala Ala Tyr Leu Tyr 
    370                 375                 380                 


Glu Val Ser Gln Leu Lys Asp 
385                 390     


<210>  2334
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNGA1__Homo_sapiens__NP_001136036

<400>  2334

Met Glu Ser Arg Ser Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile Ser 
1               5                   10                  15      


Ala His Cys Ser Leu His Leu Pro Asp Ser Ser Asp Phe Gln Leu Ile 
            20                  25                  30          


Phe Val Phe Leu Val Glu Met Gly Phe His His Val Gly Gln Ala Gly 
        35                  40                  45              


Leu Glu Leu Leu Ile Ser Ser Asp Leu Pro Thr Ser Ala Ser Gln Ser 
    50                  55                  60                  


Ala Gly Ile Thr Asp Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn 
65                  70                  75                  80  


Thr Gln Gln Ser Phe Val Thr Met Pro Asn Val Ile Val Pro Asp Ile 
                85                  90                  95      


Glu Lys Glu Ile Arg Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser 
            100                 105                 110         


Glu Asp Asp Asp Ser Ala Ser Thr Ser Glu Glu Ser Glu Asn Glu Asn 
        115                 120                 125             


Pro His Ala Arg Gly Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly 
    130                 135                 140                 


Pro Ser Gln Arg Glu Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn 
145                 150                 155                 160 


Val Asn Asn Ser Ser Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys 
                165                 170                 175     


Lys Lys Lys Glu Lys Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys 
            180                 185                 190         


Asn Asp Pro Glu Lys Lys Lys Lys Lys Lys Asp Lys Glu Lys Lys Lys 
        195                 200                 205             


Lys Glu Glu Lys Ser Lys Asp Lys Lys Glu Glu Glu Lys Lys Glu Val 
    210                 215                 220                 


Val Val Ile Asp Pro Ser Gly Asn Thr Tyr Tyr Asn Trp Leu Phe Cys 
225                 230                 235                 240 


Ile Thr Leu Pro Val Met Tyr Asn Trp Thr Met Val Ile Ala Arg Ala 
                245                 250                 255     


Cys Phe Asp Glu Leu Gln Ser Asp Tyr Leu Glu Tyr Trp Leu Ile Leu 
            260                 265                 270         


Asp Tyr Val Ser Asp Ile Val Tyr Leu Ile Asp Met Phe Val Arg Thr 
        275                 280                 285             


Arg Thr Gly Tyr Leu Glu Gln Gly Leu Leu Val Lys Glu Glu Leu Lys 
    290                 295                 300                 


Leu Ile Asn Lys Tyr Lys Ser Asn Leu Gln Phe Lys Leu Asp Val Leu 
305                 310                 315                 320 


Ser Leu Ile Pro Thr Asp Leu Leu Tyr Phe Lys Leu Gly Trp Asn Tyr 
                325                 330                 335     


Pro Glu Ile Arg Leu Asn Arg Leu Leu Arg Phe Ser Arg Met Phe Glu 
            340                 345                 350         


Phe Phe Gln Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Ile Phe Arg 
        355                 360                 365             


Ile Ser Asn Leu Val Met Tyr Ile Val Ile Ile Ile His Trp Asn Ala 
    370                 375                 380                 


Cys Val Phe Tyr Ser Ile Ser Lys Ala Ile Gly Phe Gly Asn Asp Thr 
385                 390                 395                 400 


Trp Val Tyr Pro Asp Ile Asn Asp Pro Glu Phe Gly Arg Leu Ala Arg 
                405                 410                 415     


Lys Tyr Val Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile 
            420                 425                 430         


Gly Glu Thr Pro Pro Pro Val Arg Asp Ser Glu Tyr Val Phe Val Val 
        435                 440                 445             


Val Asp Phe Leu Ile Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn 
    450                 455                 460                 


Ile Gly Ser Met Ile Ser Asn Met Asn Ala Ala Arg Ala Glu Phe Gln 
465                 470                 475                 480 


Ala Arg Ile Asp Ala Ile Lys Gln Tyr Met His Phe Arg Asn Val Ser 
                485                 490                 495     


Lys Asp Met Glu Lys Arg Val Ile Lys Trp Phe Asp Tyr Leu Trp Thr 
            500                 505                 510         


Asn Lys Lys Thr Val Asp Glu Lys Glu Val Leu Lys Tyr Leu Pro Asp 
        515                 520                 525             


Lys Leu Arg Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys 
    530                 535                 540                 


Lys Val Arg Ile Phe Ala Asp Cys Glu Ala Gly Leu Leu Val Glu Leu 
545                 550                 555                 560 


Val Leu Lys Leu Gln Pro Gln Val Tyr Ser Pro Gly Asp Tyr Ile Cys 
                565                 570                 575     


Lys Lys Gly Asp Ile Gly Arg Glu Met Tyr Ile Ile Lys Glu Gly Lys 
            580                 585                 590         


Leu Ala Val Val Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser 
        595                 600                 605             


Asp Gly Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser 
    610                 615                 620                 


Lys Ala Gly Asn Arg Arg Thr Ala Asn Ile Lys Ser Ile Gly Tyr Ser 
625                 630                 635                 640 


Asp Leu Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu 
                645                 650                 655     


Tyr Pro Asp Ala Lys Thr Met Leu Glu Glu Lys Gly Lys Gln Ile Leu 
            660                 665                 670         


Met Lys Asp Gly Leu Leu Asp Leu Asn Ile Ala Asn Ala Gly Ser Asp 
        675                 680                 685             


Pro Lys Asp Leu Glu Glu Lys Val Thr Arg Met Glu Gly Ser Val Asp 
    690                 695                 700                 


Leu Leu Gln Thr Arg Phe Ala Arg Ile Leu Ala Glu Tyr Glu Ser Met 
705                 710                 715                 720 


Gln Gln Lys Leu Lys Gln Arg Leu Thr Lys Val Glu Lys Phe Leu Lys 
                725                 730                 735     


Pro Leu Ile Asp Thr Glu Phe Ser Ser Ile Glu Gly Pro Gly Ala Glu 
            740                 745                 750         


Ser Gly Pro Ile Asp Ser Thr 
        755                 


<210>  2335
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNGA3__Homo_sapiens__NP_001073347

<400>  2335

Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      


Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Arg Lys Lys Thr Lys Lys Lys Asp Ala Ile Val Val Asp 
    130                 135                 140                 


Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala Leu Pro 
145                 150                 155                 160 


Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe Asp Glu 
                165                 170                 175     


Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr Ser Ala 
            180                 185                 190         


Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr Gly Phe 
        195                 200                 205             


Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp Gln His 
    210                 215                 220                 


Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu Val Pro 
225                 230                 235                 240 


Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu Val Arg 
                245                 250                 255     


Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe Asp Arg 
            260                 265                 270         


Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly Asn Leu 
        275                 280                 285             


Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile Tyr Phe 
    290                 295                 300                 


Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val Tyr Pro 
305                 310                 315                 320 


Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr Ile Tyr 
                325                 330                 335     


Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro 
            340                 345                 350         


Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp Phe Leu 
        355                 360                 365             


Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly Ser Met 
    370                 375                 380                 


Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys Ile Asp 
385                 390                 395                 400 


Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp Leu Glu 
                405                 410                 415     


Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys Lys Thr 
            420                 425                 430         


Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu Lys Ala 
        435                 440                 445             


Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val Arg Ile 
    450                 455                 460                 


Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu 
465                 470                 475                 480 


Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp 
                485                 490                 495     


Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala Val Val 
            500                 505                 510         


Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly Ser Tyr 
        515                 520                 525             


Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser Gly Asn 
    530                 535                 540                 


Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu Phe Cys 
545                 550                 555                 560 


Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro Glu Ala 
                565                 570                 575     


Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys Asp Asn 
            580                 585                 590         


Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys Asp Leu 
        595                 600                 605             


Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu Gln Thr 
    610                 615                 620                 


Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met Lys Met 
625                 630                 635                 640 


Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly Gly Asp 
                645                 650                 655     


Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys Thr Glu 
            660                 665                 670         


Asp Lys Gln Gln 
        675     


<210>  2336
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNGB1__Homo_sapiens__NP_001129111

<400>  2336

Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Thr Pro 
1               5                   10                  15      


Arg Lys Thr Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          


Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Thr 
        35                  40                  45              


Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  


Ala Val Ala Asp Pro Ser Pro Gln Glu Thr Lys Glu Ala Ala Leu Thr 
65                  70                  75                  80  


Ser Thr Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      


Ser Pro Ser Arg Arg Val Leu Thr Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         


Val Ile Pro Gln Pro Val His Ser Ile Thr Glu Asp Pro Ala Gln Ile 
        115                 120                 125             


Leu Gly His Gly Ser Thr Gly Asp Thr Gly Cys Thr Asp Glu Pro Asn 
    130                 135                 140                 


Glu Ala Leu Glu Ala Gln Asp Thr Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 


Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     


Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Thr Gly Ala Ala Ser 
            180                 185                 190         


Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln 
        195                 200                 205             


Ala Arg Glu Thr Pro Ser Leu Pro Thr Pro Ile Pro Leu Gln Pro Lys 
    210                 215                 220                 


Glu Glu Pro Lys Glu Ala Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln 
225                 230                 235                 240 


Ala Gln Thr Ser Ser Leu Pro Pro Thr Arg Asp Pro Ala Arg Leu Val 
                245                 250                 255     


Ala Trp Val Leu His Arg Leu Glu Met Ala Leu Pro Gln Pro Val Leu 
            260                 265                 270         


His Gly Lys Ile Gly Glu Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp 
        275                 280                 285             


Val Gln Thr Arg Val Met Gly Ala Gly Gly Leu 
    290                 295                 


<210>  2337
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNGB3__Homo_sapiens__NP_061971

<400>  2337

Met Phe Lys Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15      


Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30          


Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45              


Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser Glu Glu 
    50                  55                  60                  


Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80  


Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Thr Gly 
                85                  90                  95      


Thr Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110         


Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125             


Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 
    130                 135                 140                 


Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175     


Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190         


Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205             


Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220                 


Val Thr Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240 


Val Phe Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255     


Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270         


Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285             


Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val 
    290                 295                 300                 


Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320 


Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu 
                325                 330                 335     


Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350         


Val Ile Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365             


Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 
    370                 375                 380                 


Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400 


Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 
                405                 410                 415     


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430         


Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445             


Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala 
    450                 455                 460                 


Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480 


Thr Trp Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495     


Asp Leu Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510         


Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525             


Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540                 


Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560 


Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575     


Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590         


Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn Val 
        595                 600                 605             


Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 
    610                 615                 620                 


Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640 


Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 
                645                 650                 655     


Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr 
            660                 665                 670         


Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser Leu 
        675                 680                 685             


Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700                 


Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720 


Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735     


Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750         


Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765             


Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 
    770                 775                 780                 


Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr 
785                 790                 795                 800 


Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805                 


<210>  2338
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNIH3__Homo_sapiens__NP_689708

<400>  2338

Met Ala Phe Thr Phe Ala Ala Phe Cys Tyr Met Leu Ser Leu Val Leu 
1               5                   10                  15      


Cys Ala Ala Leu Ile Phe Phe Ala Ile Trp His Ile Ile Ala Phe Asp 
            20                  25                  30          


Glu Leu Arg Thr Asp Phe Lys Ser Pro Ile Asp Gln Cys Asn Pro Val 
        35                  40                  45              


His Ala Arg Glu Arg Leu Arg Asn Ile Glu Arg Ile Cys Phe Leu Leu 
    50                  55                  60                  


Arg Lys Leu Val Leu Pro Glu Tyr Ser Ile His Ser Leu Phe Cys Ile 
65                  70                  75                  80  


Met Phe Leu Cys Ala Gln Glu Trp Leu Thr Leu Gly Leu Asn Val Pro 
                85                  90                  95      


Leu Leu Phe Tyr His Phe Trp Arg Tyr Phe His Cys Pro Ala Asp Ser 
            100                 105                 110         


Ser Glu Leu Ala Tyr Asp Pro Pro Val Val Met Asn Ala Asp Thr Leu 
        115                 120                 125             


Ser Tyr Cys Gln Lys Glu Ala Trp Cys Lys Leu Ala Phe Tyr Leu Leu 
    130                 135                 140                 


Ser Phe Phe Tyr Tyr Leu Tyr Cys Met Ile Tyr Thr Leu Val Ser Ser 
145                 150                 155                 160 


<210>  2339
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNKSR1__Homo_sapiens__NP_001284576

<400>  2339

Met Glu Pro Val Glu Thr Trp Thr Pro Gly Lys Val Ala Thr Trp Leu 
1               5                   10                  15      


Arg Gly Leu Asp Asp Ser Leu Gln Asp Tyr Pro Phe Glu Asp Trp Gln 
            20                  25                  30          


Leu Pro Gly Lys Asn Leu Leu Gln Leu Cys Pro Gln Ser Leu Glu Ala 
        35                  40                  45              


Leu Ala Val Arg Ser Leu Gly His Gln Glu Leu Ile Leu Gly Gly Val 
    50                  55                  60                  


Glu Gln Leu Gln Ala Leu Ser Ser Arg Leu Gln Thr Glu Asn Leu Gln 
65                  70                  75                  80  


Ser Leu Thr Glu Gly Leu Leu Gly Ala Thr His Asp Phe Gln Ser Ile 
                85                  90                  95      


Val Gln Gly Cys Leu Gly Asp Cys Ala Lys Thr Pro Ile Asp Val Leu 
            100                 105                 110         


Cys Ala Ala Val Glu Leu Leu His Glu Ala Asp Ala Leu Leu Phe Trp 
        115                 120                 125             


Leu Ser Arg Tyr Leu Phe Ser His Leu Asn Asp Phe Ser Ala Cys Gln 
    130                 135                 140                 


Glu Ile Arg Asp Leu Leu Glu Glu Leu Ser Gln Val Leu His Glu Asp 
145                 150                 155                 160 


Gly Pro Ala Ala Glu Lys Glu Gly Thr Val Leu Arg Ile Cys Ser His 
                165                 170                 175     


Val Ala Gly Ile Cys His Asn Ile Leu Val Cys Cys Pro Lys Glu Leu 
            180                 185                 190         


Leu Glu Gln Lys Ala Val Leu Glu Gln Val Gln Leu Asp Ser Pro Leu 
        195                 200                 205             


Gly Leu Glu Ile His Thr Thr Ser Asn Cys Gln His Phe Val Ser Gln 
    210                 215                 220                 


Val Asp Thr Gln Val Pro Thr Asp Ser Arg Leu Gln Ile Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Val Val Gln Ile Asn Glu Gln Val Val Val Arg Glu Glu Arg 
                245                 250                 255     


Asp Met Val Gly Trp Pro Arg Lys Asn Met Val Arg Glu Leu Leu Arg 
            260                 265                 270         


Glu Pro Ala Gly Leu Ser Leu Val Leu Lys Lys Ile Pro Ile Pro Glu 
        275                 280                 285             


Thr Pro Pro Gln Thr Pro Pro Gln Val Leu Asp Ser Pro His Gln Arg 
    290                 295                 300                 


Ser Pro Ser Leu Ser Leu Ala Pro Leu Ser Pro Arg Ala Pro Ser Glu 
305                 310                 315                 320 


Asp Val Phe Ala Phe Asp Leu Ser Ser Asn Pro Ser Pro Gly Pro Ser 
                325                 330                 335     


Pro Ala Trp Thr Asp Ser Ala Ser Leu Gly Pro Glu Pro Leu Pro Ile 
            340                 345                 350         


Pro Pro Glu Pro Pro Ala Ile Leu Pro Ala Gly Val Ala Gly Thr Pro 
        355                 360                 365             


Gly Leu Pro Glu Ser Pro Asp Lys Ser Pro Val Gly Arg Lys Lys Ser 
    370                 375                 380                 


Lys Gly Leu Ala Thr Arg Leu Ser Arg Arg Arg Val Ser Cys Arg Glu 
385                 390                 395                 400 


Leu Gly Arg Pro Asp Cys Asp Gly Trp Leu Leu Leu Arg Lys Ala Pro 
                405                 410                 415     


Gly Gly Phe Met Gly Pro Arg Trp Arg Arg Arg Trp Phe Val Leu Lys 
            420                 425                 430         


Gly His Thr Leu Tyr Trp Tyr Arg Gln Pro Gln Asp Glu Lys Ala Glu 
        435                 440                 445             


Gly Leu Ile Asn Val Ser Asn Tyr Ser Leu Glu Ser Gly His Asp Gln 
    450                 455                 460                 


Lys Lys Lys Tyr Val Phe Gln Leu Thr His Asp Val Tyr Lys Pro Phe 
465                 470                 475                 480 


Ile Phe Ala Ala Asp Thr Leu Thr Asp Leu Ser Met Trp Val Arg His 
                485                 490                 495     


Leu Ile Thr Cys Ile Ser Lys Tyr Gln Ser Pro Gly Arg Ala Pro Pro 
            500                 505                 510         


Pro Arg Glu Glu Asp Cys Tyr Ser Glu Thr Glu Ala Glu Asp Pro Asp 
        515                 520                 525             


Asp Glu Ala Gly Ser His Ser Ala Ser Pro Ser Pro Ala Gln Ala Gly 
    530                 535                 540                 


Ser Pro Leu His Gly Asp Thr Ser Pro Ala Ala Thr Pro Thr Gln Arg 
545                 550                 555                 560 


Ser Pro Arg Thr Ser Phe Gly Ser Leu Thr Asp Ser Ser Glu Glu Ala 
                565                 570                 575     


Leu Glu Gly Met Val Arg Gly Leu Arg Gln Gly Gly Val Ser Leu Leu 
            580                 585                 590         


Gly Gln Pro Gln Pro Leu Thr Gln Glu Gln Trp Arg Ser Ser Phe Met 
        595                 600                 605             


Arg Arg Asn Arg Asp Pro Gln Leu Asn Glu Arg Val His Arg Val Arg 
    610                 615                 620                 


Ala Leu Gln Ser Thr Leu Lys Ala Lys Leu Gln Glu Leu Gln Val Leu 
625                 630                 635                 640 


Glu Glu Val Leu Gly Asp Pro Glu Leu Thr Gly Glu Lys Phe Arg Gln 
                645                 650                 655     


Trp Lys Glu Gln Asn Arg Glu Leu Tyr Ser Glu Gly Leu Gly Ala Trp 
            660                 665                 670         


Gly Val Ala Gln Ala Glu Gly Ser Ser His Ile Leu Thr Ser Asp Ser 
        675                 680                 685             


Thr Glu Gln Ser Pro His Ser Leu Pro Ser Asp Pro Glu Glu His Ser 
    690                 695                 700                 


His Leu Cys Pro Leu Thr Ser Glu Ser Ser Leu Arg Pro Pro Asp Leu 
705                 710                 715                 720 


<210>  2340
<211>  1004
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNKSR2__Homo_sapiens__NP_001162118

<400>  2340

Met Ala Leu Ile Met Glu Pro Val Ser Lys Trp Ser Pro Ser Gln Val 
1               5                   10                  15      


Val Asp Trp Met Lys Gly Leu Asp Asp Cys Leu Gln Gln Tyr Ile Lys 
            20                  25                  30          


Asn Phe Glu Arg Glu Lys Ile Ser Gly Asp Gln Leu Leu Arg Ile Thr 
        35                  40                  45              


His Gln Glu Leu Glu Asp Leu Gly Val Ser Arg Ile Gly His Gln Glu 
    50                  55                  60                  


Leu Ile Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu 
65                  70                  75                  80  


Glu Thr Glu Asn Leu Lys Thr Leu Ser His Lys Leu Asn Ala Ser Ala 
                85                  90                  95      


Lys Asn Leu Gln Asn Phe Ile Thr Gly Arg Arg Arg Ser Gly His Tyr 
            100                 105                 110         


Asp Gly Arg Thr Ser Arg Lys Leu Pro Asn Asp Phe Leu Thr Ser Val 
        115                 120                 125             


Val Asp Leu Ile Gly Ala Ala Lys Ser Leu Leu Ala Trp Leu Asp Arg 
    130                 135                 140                 


Ser Pro Phe Ala Ala Val Thr Asp Tyr Ser Val Thr Arg Asn Asn Val 
145                 150                 155                 160 


Ile Gln Leu Cys Leu Glu Leu Thr Thr Ile Val Gln Gln Asp Cys Thr 
                165                 170                 175     


Val Tyr Glu Thr Glu Asn Lys Ile Leu His Val Cys Lys Thr Leu Ser 
            180                 185                 190         


Gly Val Cys Asp His Ile Ile Ser Leu Ser Ser Asp Pro Leu Val Ser 
        195                 200                 205             


Gln Ser Ala His Leu Glu Val Ile Gln Leu Ala Asn Ile Lys Pro Ser 
    210                 215                 220                 


Glu Gly Leu Gly Met Tyr Ile Lys Ser Thr Tyr Asp Gly Leu His Val 
225                 230                 235                 240 


Ile Thr Gly Thr Thr Glu Asn Ser Pro Ala Asp Arg Cys Lys Lys Ile 
                245                 250                 255     


His Ala Gly Asp Glu Val Ile Gln Val Asn His Gln Thr Val Val Gly 
            260                 265                 270         


Trp Gln Leu Lys Asn Leu Val Asn Ala Leu Arg Glu Asp Pro Ser Gly 
        275                 280                 285             


Val Ile Leu Thr Leu Lys Lys Arg Pro Gln Ser Met Leu Thr Ser Ala 
    290                 295                 300                 


Pro Ala Leu Leu Lys Asn Met Arg Trp Lys Pro Leu Ala Leu Gln Pro 
305                 310                 315                 320 


Leu Ile Pro Arg Ser Pro Thr Ser Ser Val Ala Thr Pro Ser Ser Thr 
                325                 330                 335     


Ile Ser Thr Pro Thr Lys Arg Asp Ser Ser Ala Leu Gln Asp Leu Tyr 
            340                 345                 350         


Ile Pro Pro Pro Pro Ala Glu Pro Tyr Ile Pro Arg Asp Glu Lys Gly 
        355                 360                 365             


Asn Leu Pro Cys Glu Asp Leu Arg Gly His Met Val Gly Lys Pro Val 
    370                 375                 380                 


His Lys Gly Ser Glu Ser Pro Asn Ser Phe Leu Asp Gln Glu Tyr Arg 
385                 390                 395                 400 


Lys Arg Phe Asn Ile Val Glu Glu Asp Thr Val Leu Tyr Cys Tyr Glu 
                405                 410                 415     


Tyr Glu Lys Gly Arg Ser Ser Ser Gln Gly Arg Arg Glu Ser Thr Pro 
            420                 425                 430         


Thr Tyr Glu Asn Ser Leu Leu Arg Tyr Met Ser Asn Glu Lys Ile Ala 
        435                 440                 445             


Gln Glu Glu Tyr Met Phe Gln Arg Asn Ser Lys Lys Asp Thr Gly Lys 
    450                 455                 460                 


Lys Ser Lys Lys Lys Gly Asp Lys Ser Asn Ser Pro Thr His Tyr Ser 
465                 470                 475                 480 


Leu Leu Pro Ser Leu Gln Met Asp Ala Leu Arg Gln Asp Ile Met Gly 
                485                 490                 495     


Thr Pro Val Pro Glu Thr Thr Leu Tyr His Thr Phe Gln Gln Ser Ser 
            500                 505                 510         


Leu Gln His Lys Ser Lys Lys Lys Asn Lys Gly Pro Ile Ala Gly Lys 
        515                 520                 525             


Ser Lys Arg Arg Ile Ser Cys Lys Asp Leu Gly Arg Gly Asp Cys Glu 
    530                 535                 540                 


Gly Trp Leu Trp Lys Lys Lys Asp Ala Lys Ser Tyr Phe Ser Gln Lys 
545                 550                 555                 560 


Trp Lys Lys Tyr Trp Phe Val Leu Lys Asp Ala Ser Leu Tyr Trp Tyr 
                565                 570                 575     


Ile Asn Glu Glu Asp Glu Lys Ala Glu Gly Phe Ile Ser Leu Pro Glu 
            580                 585                 590         


Phe Lys Ile Asp Arg Ala Ser Glu Cys Arg Lys Lys Tyr Ala Phe Lys 
        595                 600                 605             


Ala Cys His Pro Lys Ile Lys Ser Phe Tyr Phe Ala Ala Glu His Leu 
    610                 615                 620                 


Asp Asp Met Asn Arg Trp Leu Asn Arg Ile Asn Met Leu Thr Ala Gly 
625                 630                 635                 640 


Tyr Ala Glu Arg Glu Arg Ile Lys Gln Glu Gln Asp Tyr Trp Ser Glu 
                645                 650                 655     


Ser Asp Lys Glu Glu Ala Asp Thr Pro Ser Thr Pro Lys Gln Asp Ser 
            660                 665                 670         


Pro Pro Pro Pro Tyr Asp Thr Tyr Pro Arg Pro Pro Ser Met Ser Cys 
        675                 680                 685             


Ala Ser Pro Tyr Val Glu Ala Lys His Ser Arg Leu Ser Ser Thr Glu 
    690                 695                 700                 


Thr Ser Gln Ser Gln Ser Ser His Glu Glu Phe Arg Gln Glu Val Thr 
705                 710                 715                 720 


Gly Ser Ser Ala Val Ser Pro Ile Arg Lys Thr Ala Ser Gln Arg Arg 
                725                 730                 735     


Ser Trp Gln Asp Leu Ile Glu Thr Pro Leu Thr Ser Ser Gly Leu His 
            740                 745                 750         


Tyr Leu Gln Thr Leu Pro Leu Glu Asp Ser Val Phe Ser Asp Ser Ala 
        755                 760                 765             


Ala Ile Ser Pro Glu His Arg Arg Gln Ser Thr Leu Pro Thr Gln Lys 
    770                 775                 780                 


Cys His Leu Gln Asp His Tyr Gly Pro Tyr Pro Leu Ala Glu Ser Glu 
785                 790                 795                 800 


Arg Met Gln Val Leu Asn Gly Asn Gly Gly Lys Pro Arg Ser Phe Thr 
                805                 810                 815     


Leu Pro Arg Asp Ser Gly Phe Asn His Cys Cys Leu Asn Ala Pro Val 
            820                 825                 830         


Ser Ala Cys Asp Pro Gln Asp Asp Val Gln Pro Pro Glu Val Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu Ala Ala Gly Glu Asn Ile 
    850                 855                 860                 


Gly Glu Lys Ser Glu Ser Arg Glu Glu Lys Leu Gly Asp Ser Leu Gln 
865                 870                 875                 880 


Asp Leu Tyr Arg Ala Leu Glu Gln Ala Ser Leu Ser Pro Leu Gly Glu 
                885                 890                 895     


His Arg Ile Ser Thr Lys Met Glu Tyr Lys Leu Ser Phe Ile Lys Arg 
            900                 905                 910         


Cys Asn Asp Pro Val Met Asn Glu Lys Leu His Arg Leu Arg Ile Leu 
        915                 920                 925             


Lys Ser Thr Leu Lys Ala Arg Glu Gly Glu Val Ala Ile Ile Asp Lys 
    930                 935                 940                 


Val Leu Asp Asn Pro Asp Leu Thr Ser Lys Glu Phe Gln Gln Trp Lys 
945                 950                 955                 960 


Gln Met Tyr Leu Asp Leu Phe Leu Asp Ile Cys Gln Asn Thr Thr Ser 
                965                 970                 975     


Asn Asp Pro Leu Ser Ile Ser Ser Glu Val Asp Val Ile Thr Ser Ser 
            980                 985                 990         


Leu Ala His Thr His Ser Tyr Ile  Glu Thr His Val 
        995                 1000                 


<210>  2341
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNKSR3__Homo_sapiens__NP_775786

<400>  2341

Met Glu Pro Val Thr Lys Trp Ser Pro Lys Gln Val Val Asp Trp Thr 
1               5                   10                  15      


Arg Gly Leu Asp Asp Cys Leu Gln Gln Tyr Val His Lys Phe Glu Arg 
            20                  25                  30          


Glu Lys Ile Asn Gly Glu Gln Leu Leu Gln Ile Ser His Gln Asp Leu 
        35                  40                  45              


Glu Glu Leu Gly Val Thr Arg Ile Gly His Gln Glu Leu Val Leu Glu 
    50                  55                  60                  


Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu Glu Thr Asp Asn 
65                  70                  75                  80  


Met Lys Asn Leu Val Leu Lys Leu Arg Ala Ser Ser His Asn Leu Gln 
                85                  90                  95      


Asn Tyr Ile Ser Ser Arg Arg Lys Ser Pro Ala Tyr Asp Gly Asn Thr 
            100                 105                 110         


Ser Arg Lys Ala Pro Asn Glu Phe Leu Thr Ser Val Val Glu Leu Ile 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Ala Trp Leu Asp Arg Ala Pro Phe Thr 
    130                 135                 140                 


Gly Ile Thr Asp Phe Ser Val Thr Lys Asn Lys Ile Ile Gln Leu Cys 
145                 150                 155                 160 


Leu Asp Leu Thr Thr Thr Val Gln Lys Asp Cys Phe Val Ala Glu Met 
                165                 170                 175     


Glu Asp Lys Val Leu Thr Val Val Lys Val Leu Asn Gly Ile Cys Asp 
            180                 185                 190         


Lys Thr Ile Arg Ser Thr Thr Asp Pro Val Met Ser Gln Cys Ala Cys 
        195                 200                 205             


Leu Glu Glu Val His Leu Pro Asn Ile Lys Pro Gly Glu Gly Leu Gly 
    210                 215                 220                 


Met Tyr Ile Lys Ser Thr Tyr Asp Gly Leu His Val Ile Thr Gly Thr 
225                 230                 235                 240 


Thr Glu Asn Ser Pro Ala Asp Arg Ser Gln Lys Ile His Ala Gly Asp 
                245                 250                 255     


Glu Val Ile Gln Val Asn Gln Gln Thr Val Val Gly Trp Gln Leu Lys 
            260                 265                 270         


Asn Leu Val Lys Lys Leu Arg Glu Asn Pro Thr Gly Val Val Leu Leu 
        275                 280                 285             


Leu Lys Lys Arg Pro Thr Gly Ser Phe Asn Phe Thr Pro Ala Pro Leu 
    290                 295                 300                 


Lys Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Thr Ser Pro Pro Pro 
305                 310                 315                 320 


Ala Thr Thr Gln Ser Pro Glu Ser Thr Met Asp Thr Ser Leu Lys Lys 
                325                 330                 335     


Glu Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro Ala Val 
            340                 345                 350         


Pro Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly Gly Ser 
        355                 360                 365             


Ser Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu Ser Pro 
    370                 375                 380                 


Asn Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe Thr Ile Ala 
385                 390                 395                 400 


Asp Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Thr Asn Ile Leu Pro 
                405                 410                 415     


Thr Lys Met Arg Glu Lys Thr Pro Ser Tyr Gly Lys Pro Arg Pro Leu 
            420                 425                 430         


Ser Met Pro Ala Asp Gly Asn Trp Met Gly Ile Val Asp Pro Phe Ala 
        435                 440                 445             


Arg Pro Arg Gly His Gly Arg Lys Gly Glu Asp Ala Leu Cys Arg Tyr 
    450                 455                 460                 


Phe Ser Asn Glu Arg Ile Pro Pro Ile Ile Glu Glu Ser Ser Ser Pro 
465                 470                 475                 480 


Pro Tyr Arg Phe Ser Arg Pro Thr Thr Glu Arg His Leu Val Arg Gly 
                485                 490                 495     


Ala Asp Tyr Ile Arg Gly Ser Arg Cys Tyr Ile Asn Ser Asp Leu His 
            500                 505                 510         


Ser Ser Ala Thr Ile Pro Phe Gln Glu Glu Gly Thr Lys Lys Lys Ser 
        515                 520                 525             


Gly Ser Ser Ala Thr Lys Ser Ser Ser Thr Glu Pro Ser Leu Leu Val 
    530                 535                 540                 


Ser Trp Phe Thr Arg Leu Lys Leu Leu Thr His 
545                 550                 555 


<210>  2342
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNN1__Homo_sapiens__NP_001290

<400>  2342

Met Ser Ser Ala His Phe Asn Arg Gly Pro Ala Tyr Gly Leu Ser Ala 
1               5                   10                  15      


Glu Val Lys Asn Lys Leu Ala Gln Lys Tyr Asp His Gln Arg Glu Gln 
            20                  25                  30          


Glu Leu Arg Glu Trp Ile Glu Gly Val Thr Gly Arg Arg Ile Gly Asn 
        35                  40                  45              


Asn Phe Met Asp Gly Leu Lys Asp Gly Ile Ile Leu Cys Glu Phe Ile 
    50                  55                  60                  


Asn Lys Leu Gln Pro Gly Ser Val Lys Lys Ile Asn Glu Ser Thr Gln 
65                  70                  75                  80  


Asn Trp His Gln Leu Glu Asn Ile Gly Asn Phe Ile Lys Ala Ile Thr 
                85                  90                  95      


Lys Tyr Gly Val Lys Pro His Asp Ile Phe Glu Ala Asn Asp Leu Phe 
            100                 105                 110         


Glu Asn Thr Asn His Thr Gln Val Gln Ser Thr Leu Leu Ala Leu Ala 
        115                 120                 125             


Ser Met Ala Lys Thr Lys Gly Asn Lys Val Asn Val Gly Val Lys Tyr 
    130                 135                 140                 


Ala Glu Lys Gln Glu Arg Lys Phe Glu Pro Gly Lys Leu Arg Glu Gly 
145                 150                 155                 160 


Arg Asn Ile Ile Gly Leu Gln Met Gly Thr Asn Lys Phe Ala Ser Gln 
                165                 170                 175     


Gln Gly Met Thr Ala Tyr Gly Thr Arg Arg His Leu Tyr Asp Pro Lys 
            180                 185                 190         


Leu Gly Thr Asp Gln Pro Leu Asp Gln Ala Thr Ile Ser Leu Gln Met 
        195                 200                 205             


Gly Thr Asn Lys Gly Ala Ser Gln Ala Gly Met Thr Ala Pro Gly Thr 
    210                 215                 220                 


Lys Arg Gln Ile Phe Glu Pro Gly Leu Gly Met Glu His Cys Asp Thr 
225                 230                 235                 240 


Leu Asn Val Ser Leu Gln Met Gly Ser Asn Lys Gly Ala Ser Gln Arg 
                245                 250                 255     


Gly Met Thr Val Tyr Gly Leu Pro Arg Gln Val Tyr Asp Pro Lys Tyr 
            260                 265                 270         


Cys Leu Thr Pro Glu Tyr Pro Glu Leu Gly Glu Pro Ala His Asn His 
        275                 280                 285             


His Ala His Asn Tyr Tyr Asn Ser Ala 
    290                 295         


<210>  2343
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNN2__Homo_sapiens__NP_004359

<400>  2343

Met Ser Ser Thr Gln Phe Asn Lys Gly Pro Ser Tyr Gly Leu Ser Ala 
1               5                   10                  15      


Glu Val Lys Asn Arg Leu Leu Ser Lys Tyr Asp Pro Gln Lys Glu Ala 
            20                  25                  30          


Glu Leu Arg Thr Trp Ile Glu Gly Leu Thr Gly Leu Ser Ile Gly Pro 
        35                  40                  45              


Asp Phe Gln Lys Gly Leu Lys Asp Gly Thr Ile Leu Cys Thr Leu Met 
    50                  55                  60                  


Asn Lys Leu Gln Pro Gly Ser Val Pro Lys Ile Asn Arg Ser Met Gln 
65                  70                  75                  80  


Asn Trp His Gln Leu Glu Asn Leu Ser Asn Phe Ile Lys Ala Met Val 
                85                  90                  95      


Ser Tyr Gly Met Asn Pro Val Asp Leu Phe Glu Ala Asn Asp Leu Phe 
            100                 105                 110         


Glu Ser Gly Asn Met Thr Gln Val Gln Val Ser Leu Leu Ala Leu Ala 
        115                 120                 125             


Gly Lys Ala Lys Thr Lys Gly Leu Gln Ser Gly Val Asp Ile Gly Val 
    130                 135                 140                 


Lys Tyr Ser Glu Lys Gln Glu Arg Asn Phe Asp Asp Ala Thr Met Lys 
145                 150                 155                 160 


Ala Gly Gln Cys Val Ile Gly Leu Gln Met Gly Thr Asn Lys Cys Ala 
                165                 170                 175     


Ser Gln Ser Gly Met Thr Ala Tyr Gly Thr Arg Arg His Leu Tyr Asp 
            180                 185                 190         


Pro Lys Asn His Ile Leu Pro Pro Met Asp His Ser Thr Ile Ser Leu 
        195                 200                 205             


Gln Met Gly Thr Asn Lys Cys Ala Ser Gln Val Gly Met Thr Ala Pro 
    210                 215                 220                 


Gly Thr Arg Arg His Ile Tyr Asp Thr Lys Leu Gly Thr Asp Lys Cys 
225                 230                 235                 240 


Asp Asn Ser Ser Met Ser Leu Gln Met Gly Tyr Thr Gln Gly Ala Asn 
                245                 250                 255     


Gln Ser Gly Gln Val Phe Gly Leu Gly Arg Gln Ile Tyr Asp Pro Lys 
            260                 265                 270         


Tyr Cys Pro Gln Gly Thr Val Ala Asp Gly Ala Pro Ser Gly Thr Gly 
        275                 280                 285             


Asp Cys Pro Asp Pro Gly Glu Val Pro Glu Tyr Pro Pro Tyr Tyr Gln 
    290                 295                 300                 


Glu Glu Ala Gly Tyr 
305                 


<210>  2344
<211>  951
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNNM1__Homo_sapiens__NP_065081

<400>  2344

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Gly Val Arg Leu Arg 
1               5                   10                  15      


Asp Cys Cys Ser Arg Gly Ala Val Leu Leu Leu Phe Phe Ser Leu Ser 
            20                  25                  30          


Pro Arg Pro Pro Ala Ala Ala Ala Trp Leu Leu Gly Leu Arg Pro Glu 
        35                  40                  45              


Asp Thr Ala Gly Gly Arg Val Ser Leu Glu Gly Gly Thr Leu Arg Ala 
    50                  55                  60                  


Ala Glu Gly Thr Ser Phe Leu Leu Arg Val Tyr Phe Gln Pro Gly Pro 
65                  70                  75                  80  


Pro Ala Thr Ala Ala Pro Val Pro Ser Pro Thr Leu Asn Ser Gly Glu 
                85                  90                  95      


Asn Gly Thr Gly Asp Trp Ala Pro Arg Leu Val Phe Ile Glu Glu Pro 
            100                 105                 110         


Pro Gly Gly Gly Gly Val Ala Pro Ser Ala Val Pro Thr Arg Pro Pro 
        115                 120                 125             


Gly Pro Gln Arg Cys Arg Glu Gln Ser Asp Trp Ala Ser Asp Val Glu 
    130                 135                 140                 


Val Leu Gly Pro Leu Arg Pro Gly Gly Val Ala Gly Ser Ala Leu Val 
145                 150                 155                 160 


Gln Val Arg Val Arg Glu Leu Arg Lys Gly Glu Ala Glu Arg Gly Gly 
                165                 170                 175     


Ala Gly Gly Gly Gly Lys Leu Phe Ser Leu Cys Ala Trp Asp Gly Arg 
            180                 185                 190         


Ala Trp His His His Gly Ala Ala Gly Gly Phe Leu Leu Arg Val Arg 
        195                 200                 205             


Pro Arg Leu Tyr Gly Pro Gly Gly Asp Leu Leu Pro Pro Ala Trp Leu 
    210                 215                 220                 


Arg Ala Leu Gly Ala Leu Leu Leu Leu Ala Leu Ser Ala Leu Phe Ser 
225                 230                 235                 240 


Gly Leu Arg Leu Ser Leu Leu Ser Leu Asp Pro Val Glu Leu Arg Val 
                245                 250                 255     


Leu Arg Asn Ser Gly Ser Ala Ala Glu Gln Glu Gln Ala Arg Arg Val 
            260                 265                 270         


Gln Ala Val Arg Gly Arg Gly Thr His Leu Leu Cys Thr Leu Leu Leu 
        275                 280                 285             


Gly Gln Ala Gly Ala Asn Ala Ala Leu Ala Gly Trp Leu Tyr Thr Ser 
    290                 295                 300                 


Leu Pro Pro Gly Phe Gly Gly Thr Gly Glu Asp Tyr Ser Glu Glu Gly 
305                 310                 315                 320 


Ile His Phe Pro Trp Leu Pro Ala Leu Val Cys Thr Gly Ala Val Phe 
                325                 330                 335     


Leu Gly Ala Glu Ile Cys Pro Tyr Ser Val Cys Ser Arg His Gly Leu 
            340                 345                 350         


Ala Ile Ala Ser His Ser Val Cys Leu Thr Arg Leu Leu Met Ala Ala 
        355                 360                 365             


Ala Phe Pro Val Cys Tyr Pro Leu Gly Arg Leu Leu Asp Trp Ala Leu 
    370                 375                 380                 


Arg Gln Glu Ile Ser Thr Phe Tyr Thr Arg Glu Lys Leu Leu Glu Thr 
385                 390                 395                 400 


Leu Arg Ala Ala Asp Pro Tyr Ser Asp Leu Val Lys Glu Glu Leu Asn 
                405                 410                 415     


Ile Ile Gln Gly Ala Leu Glu Leu Arg Thr Lys Val Val Glu Glu Val 
            420                 425                 430         


Leu Thr Pro Leu Gly Asp Cys Phe Met Leu Arg Ser Asp Ala Val Leu 
        435                 440                 445             


Asp Phe Ala Thr Val Ser Glu Ile Leu Arg Ser Gly Tyr Thr Arg Ile 
    450                 455                 460                 


Pro Val Tyr Glu Gly Asp Gln Arg His Asn Ile Val Asp Ile Leu Phe 
465                 470                 475                 480 


Val Lys Asp Leu Ala Phe Val Asp Pro Asp Asp Cys Thr Pro Leu Leu 
                485                 490                 495     


Thr Val Thr Arg Phe Tyr Asn Arg Pro Leu His Cys Val Phe Asn Asp 
            500                 505                 510         


Thr Arg Leu Asp Thr Val Leu Glu Glu Phe Lys Lys Gly Lys Ser His 
        515                 520                 525             


Leu Ala Ile Val Gln Arg Val Asn Asn Glu Gly Glu Gly Asp Pro Phe 
    530                 535                 540                 


Tyr Glu Val Met Gly Ile Val Thr Leu Glu Asp Ile Ile Glu Glu Ile 
545                 550                 555                 560 


Ile Lys Ser Glu Ile Leu Asp Glu Thr Asp Leu Tyr Thr Asp Asn Arg 
                565                 570                 575     


Lys Lys Gln Arg Val Pro Gln Arg Glu Arg Lys Arg His Asp Phe Ser 
            580                 585                 590         


Leu Phe Lys Leu Ser Asp Thr Glu Met Arg Val Lys Ile Ser Pro Gln 
        595                 600                 605             


Leu Leu Leu Ala Thr His Arg Phe Met Ala Thr Glu Val Glu Pro Phe 
    610                 615                 620                 


Lys Ser Leu Tyr Leu Ser Glu Lys Ile Leu Leu Arg Leu Leu Lys His 
625                 630                 635                 640 


Pro Asn Val Ile Gln Glu Leu Lys Phe Asp Glu Lys Asn Lys Lys Ala 
                645                 650                 655     


Pro Glu His Tyr Leu Tyr Gln Arg Asn Arg Pro Val Asp Tyr Phe Val 
            660                 665                 670         


Leu Leu Leu Gln Gly Lys Val Glu Val Glu Val Gly Lys Glu Gly Leu 
        675                 680                 685             


Arg Phe Glu Asn Gly Ala Phe Thr Tyr Tyr Gly Val Pro Ala Ile Met 
    690                 695                 700                 


Thr Thr Ala Cys Ser Asp Asn Asp Val Arg Lys Val Gly Ser Leu Ala 
705                 710                 715                 720 


Gly Ser Ser Val Phe Leu Asn Arg Ser Pro Ser Arg Cys Ser Gly Leu 
                725                 730                 735     


Asn Arg Ser Glu Ser Pro Asn Arg Glu Arg Ser Asp Phe Gly Gly Ser 
            740                 745                 750         


Asn Thr Gln Leu Tyr Ser Ser Ser Asn Asn Leu Tyr Met Pro Asp Tyr 
        755                 760                 765             


Ser Val His Ile Leu Ser Asp Val Gln Phe Val Lys Ile Thr Arg Gln 
    770                 775                 780                 


Gln Tyr Gln Asn Ala Leu Thr Ala Cys His Met Asp Ser Ser Pro Gln 
785                 790                 795                 800 


Ser Pro Asp Met Glu Ala Phe Thr Asp Gly Asp Ser Thr Lys Ala Pro 
                805                 810                 815     


Thr Thr Arg Gly Thr Pro Gln Thr Pro Lys Asp Asp Pro Ala Ile Thr 
            820                 825                 830         


Leu Leu Asn Asn Arg Asn Ser Leu Pro Cys Ser Arg Ser Asp Gly Leu 
        835                 840                 845             


Arg Ser Pro Ser Glu Val Val Tyr Leu Arg Met Glu Glu Leu Ala Phe 
    850                 855                 860                 


Thr Gln Glu Glu Met Thr Asp Phe Glu Glu His Ser Thr Gln Gln Leu 
865                 870                 875                 880 


Thr Leu Ser Pro Ala Ala Val Pro Thr Arg Ala Ala Ser Asp Ser Glu 
                885                 890                 895     


Cys Cys Asn Ile Asn Leu Asp Thr Glu Thr Ser Pro Cys Ser Ser Asp 
            900                 905                 910         


Phe Glu Glu Asn Val Gly Lys Lys Leu Leu Arg Thr Leu Ser Gly Gln 
        915                 920                 925             


Lys Arg Lys Arg Ser Pro Glu Gly Glu Arg Thr Ser Glu Asp Asn Ser 
    930                 935                 940                 


Asn Leu Thr Pro Leu Ile Thr 
945                 950     


<210>  2345
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNNM2__Homo_sapiens__NP_060119

<400>  2345

Met Ile Gly Cys Gly Ala Cys Glu Pro Lys Val Lys Met Ala Gly Gly 
1               5                   10                  15      


Gln Ala Ala Ala Ala Leu Pro Thr Trp Lys Met Ala Ala Arg Arg Ser 
            20                  25                  30          


Leu Ser Ala Arg Gly Arg Gly Ile Leu Gln Ala Ala Ala Gly Arg Leu 
        35                  40                  45              


Leu Pro Leu Leu Leu Leu Ser Cys Cys Cys Gly Ala Gly Gly Cys Ala 
    50                  55                  60                  


Ala Val Gly Glu Asn Glu Glu Thr Val Ile Ile Gly Leu Arg Leu Glu 
65                  70                  75                  80  


Asp Thr Asn Asp Val Ser Phe Met Glu Gly Gly Ala Leu Arg Val Ser 
                85                  90                  95      


Glu Arg Thr Arg Val Lys Leu Arg Val Tyr Gly Gln Asn Ile Asn Asn 
            100                 105                 110         


Glu Thr Trp Ser Arg Ile Ala Phe Thr Glu His Glu Arg Arg Arg His 
        115                 120                 125             


Ser Pro Gly Glu Arg Gly Leu Gly Gly Pro Ala Pro Pro Glu Pro Asp 
    130                 135                 140                 


Ser Gly Pro Gln Arg Cys Gly Ile Arg Thr Ser Asp Ile Ile Ile Leu 
145                 150                 155                 160 


Pro His Ile Ile Leu Asn Arg Arg Thr Ser Gly Ile Ile Glu Ile Glu 
                165                 170                 175     


Ile Lys Pro Leu Arg Lys Met Glu Lys Ser Lys Ser Tyr Tyr Leu Cys 
            180                 185                 190         


Thr Ser Leu Ser Thr Pro Ala Leu Gly Ala Gly Gly Ser Gly Ser Thr 
        195                 200                 205             


Gly Gly Ala Val Gly Gly Lys Gly Gly Ser Gly Val Ala Gly Leu Pro 
    210                 215                 220                 


Pro Pro Pro Trp Ala Glu Thr Thr Trp Ile Tyr His Asp Gly Glu Asp 
225                 230                 235                 240 


Thr Lys Met Ile Val Gly Glu Glu Lys Lys Phe Leu Leu Pro Phe Trp 
                245                 250                 255     


Leu Gln Val Ile Phe Ile Ser Leu Leu Leu Cys Leu Ser Gly Met Phe 
            260                 265                 270         


Ser Gly Leu Asn Leu Gly Leu Met Ala Leu Asp Pro Met Glu Leu Arg 
        275                 280                 285             


Ile Val Gln Asn Cys Gly Thr Glu Lys Glu Lys Asn Tyr Ala Lys Arg 
    290                 295                 300                 


Ile Glu Pro Val Arg Arg Gln Gly Asn Tyr Leu Leu Cys Ser Leu Leu 
305                 310                 315                 320 


Leu Gly Asn Val Leu Val Asn Thr Thr Leu Thr Ile Leu Leu Asp Asp 
                325                 330                 335     


Ile Ala Gly Ser Gly Leu Val Ala Val Val Val Ser Thr Ile Gly Ile 
            340                 345                 350         


Val Ile Phe Gly Glu Ile Val Pro Gln Ala Ile Cys Ser Arg His Gly 
        355                 360                 365             


Leu Ala Val Gly Ala Asn Thr Ile Phe Leu Thr Lys Phe Phe Met Met 
    370                 375                 380                 


Met Thr Phe Pro Ala Ser Tyr Pro Val Ser Lys Leu Leu Asp Cys Val 
385                 390                 395                 400 


Leu Gly Gln Glu Ile Gly Thr Val Tyr Asn Arg Glu Lys Leu Leu Glu 
                405                 410                 415     


Met Leu Arg Val Thr Asp Pro Tyr Asn Asp Leu Val Lys Glu Glu Leu 
            420                 425                 430         


Asn Ile Ile Gln Gly Ala Leu Glu Leu Arg Thr Lys Thr Val Glu Asp 
        435                 440                 445             


Val Met Thr Pro Leu Arg Asp Cys Phe Met Ile Thr Gly Glu Ala Ile 
    450                 455                 460                 


Leu Asp Phe Asn Thr Met Ser Glu Ile Met Glu Ser Gly Tyr Thr Arg 
465                 470                 475                 480 


Ile Pro Val Phe Glu Gly Glu Arg Ser Asn Ile Val Asp Leu Leu Phe 
                485                 490                 495     


Val Lys Asp Leu Ala Phe Val Asp Pro Asp Asp Cys Thr Pro Leu Lys 
            500                 505                 510         


Thr Ile Thr Lys Phe Tyr Asn His Pro Leu His Phe Val Phe Asn Asp 
        515                 520                 525             


Thr Lys Leu Asp Ala Met Leu Glu Glu Phe Lys Lys Gly Lys Ser His 
    530                 535                 540                 


Leu Ala Ile Val Gln Arg Val Asn Asn Glu Gly Glu Gly Asp Pro Phe 
545                 550                 555                 560 


Tyr Glu Val Leu Gly Ile Val Thr Leu Glu Asp Val Ile Glu Glu Ile 
                565                 570                 575     


Ile Lys Ser Glu Ile Leu Asp Glu Thr Asp Leu Tyr Thr Asp Asn Arg 
            580                 585                 590         


Thr Lys Lys Lys Val Ala His Arg Glu Arg Lys Gln Asp Phe Ser Ala 
        595                 600                 605             


Phe Lys Gln Thr Asp Ser Glu Met Lys Val Lys Ile Ser Pro Gln Leu 
    610                 615                 620                 


Leu Leu Ala Met His Arg Phe Leu Ala Thr Glu Val Glu Ala Phe Ser 
625                 630                 635                 640 


Pro Ser Gln Met Ser Glu Lys Ile Leu Leu Arg Leu Leu Lys His Pro 
                645                 650                 655     


Asn Val Ile Gln Glu Leu Lys Tyr Asp Glu Lys Asn Lys Lys Ala Pro 
            660                 665                 670         


Glu Tyr Tyr Leu Tyr Gln Arg Asn Lys Pro Val Asp Tyr Phe Val Leu 
        675                 680                 685             


Ile Leu Gln Gly Lys Val Glu Val Glu Ala Gly Lys Glu Gly Met Lys 
    690                 695                 700                 


Phe Glu Ala Ser Ala Phe Ser Tyr Tyr Gly Val Met Ala Leu Thr Ala 
705                 710                 715                 720 


Ser Pro Val Pro Leu Ser Leu Ser Arg Thr Phe Val Val Ser Arg Thr 
                725                 730                 735     


Glu Leu Leu Ala Ala Gly Ser Pro Gly Glu Asn Lys Ser Pro Pro Arg 
            740                 745                 750         


Pro Cys Gly Leu Asn His Ser Asp Ser Leu Ser Arg Ser Asp Arg Ile 
        755                 760                 765             


Asp Ala Val Thr Pro Thr Leu Gly Ser Ser Asn Asn Gln Leu Asn Ser 
    770                 775                 780                 


Ser Leu Leu Gln Val Tyr Ile Pro Asp Tyr Ser Val Arg Ala Leu Ser 
785                 790                 795                 800 


Asp Leu Gln Phe Val Lys Ile Ser Arg Gln Gln Tyr Gln Asn Ala Leu 
                805                 810                 815     


Met Ala Ser Arg Met Asp Lys Thr Pro Gln Ser Ser Asp Ser Glu Asn 
            820                 825                 830         


Thr Lys Ile Glu Leu Thr Leu Thr Glu Leu His Asp Gly Leu Pro Asp 
        835                 840                 845             


Glu Thr Ala Asn Leu Leu Asn Glu Gln Asn Cys Val Thr His Ser Lys 
    850                 855                 860                 


Ala Asn His Ser Leu His Asn Glu Gly Ala Ile 
865                 870                 875 


<210>  2346
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNNM4__Homo_sapiens__NP_064569

<400>  2346

Met Ala Pro Val Gly Gly Gly Gly Arg Pro Val Gly Gly Pro Ala Arg 
1               5                   10                  15      


Gly Arg Leu Leu Leu Ala Ala Pro Val Leu Leu Val Leu Leu Trp Ala 
            20                  25                  30          


Leu Gly Ala Arg Gly Gln Gly Ser Pro Gln Gln Gly Thr Ile Val Gly 
        35                  40                  45              


Met Arg Leu Ala Ser Cys Asn Lys Ser Cys Gly Thr Asn Pro Asp Gly 
    50                  55                  60                  


Ile Ile Phe Val Ser Glu Gly Ser Thr Val Asn Leu Arg Leu Tyr Gly 
65                  70                  75                  80  


Tyr Ser Leu Gly Asn Ile Ser Ser Asn Leu Ile Ser Phe Thr Glu Val 
                85                  90                  95      


Asp Asp Ala Glu Thr Leu His Lys Ser Thr Ser Cys Leu Glu Leu Thr 
            100                 105                 110         


Lys Asp Leu Val Val Gln Gln Leu Val Asn Val Ser Arg Gly Asn Thr 
        115                 120                 125             


Ser Gly Val Leu Val Val Leu Thr Lys Phe Leu Arg Arg Ser Glu Ser 
    130                 135                 140                 


Met Lys Leu Tyr Ala Leu Cys Thr Arg Ala Gln Pro Asp Gly Pro Trp 
145                 150                 155                 160 


Leu Lys Trp Thr Asp Lys Asp Ser Leu Leu Phe Met Val Glu Glu Pro 
                165                 170                 175     


Gly Arg Phe Leu Pro Leu Trp Leu His Ile Leu Leu Ile Thr Val Leu 
            180                 185                 190         


Leu Val Leu Ser Gly Ile Phe Ser Gly Leu Asn Leu Gly Leu Met Ala 
        195                 200                 205             


Leu Asp Pro Met Glu Leu Arg Ile Val Gln Asn Cys Gly Thr Glu Lys 
    210                 215                 220                 


Glu Arg Arg Tyr Ala Arg Lys Ile Glu Pro Ile Arg Arg Lys Gly Asn 
225                 230                 235                 240 


Tyr Leu Leu Cys Ser Leu Leu Leu Gly Asn Val Leu Val Asn Thr Ser 
                245                 250                 255     


Leu Thr Ile Leu Leu Asp Asn Leu Ile Gly Ser Gly Leu Met Ala Val 
            260                 265                 270         


Ala Ser Ser Thr Ile Gly Ile Val Ile Phe Gly Glu Ile Leu Pro Gln 
        275                 280                 285             


Ala Leu Cys Ser Arg His Gly Leu Ala Val Gly Ala Asn Thr Ile Leu 
    290                 295                 300                 


Leu Thr Lys Phe Phe Met Leu Leu Thr Phe Pro Leu Ser Phe Pro Ile 
305                 310                 315                 320 


Ser Lys Leu Leu Asp Phe Phe Leu Gly Gln Glu Ile Arg Thr Val Tyr 
                325                 330                 335     


Asn Arg Glu Lys Leu Met Glu Met Leu Lys Val Thr Glu Pro Tyr Asn 
            340                 345                 350         


Asp Leu Val Lys Glu Glu Leu Asn Met Ile Gln Gly Ala Leu Glu Leu 
        355                 360                 365             


Arg Thr Lys Thr Val Glu Asp Ile Met Thr Gln Leu Gln Asp Cys Phe 
    370                 375                 380                 


Met Ile Arg Ser Asp Ala Ile Leu Asp Phe Asn Thr Met Ser Glu Ile 
385                 390                 395                 400 


Met Glu Ser Gly Tyr Thr Arg Ile Pro Val Phe Glu Asp Glu Gln Ser 
                405                 410                 415     


Asn Ile Val Asp Ile Leu Tyr Val Lys Asp Leu Ala Phe Val Asp Pro 
            420                 425                 430         


Asp Asp Cys Thr Pro Leu Lys Thr Ile Thr Arg Phe Tyr Asn His Pro 
        435                 440                 445             


Val His Phe Val Phe His Asp Thr Lys Leu Asp Ala Met Leu Glu Glu 
    450                 455                 460                 


Phe Lys Lys Gly Lys Ser His Leu Ala Ile Val Gln Lys Val Asn Asn 
465                 470                 475                 480 


Glu Gly Glu Gly Asp Pro Phe Tyr Glu Val Leu Gly Leu Val Thr Leu 
                485                 490                 495     


Glu Asp Val Ile Glu Glu Ile Ile Lys Ser Glu Ile Leu Asp Glu Ser 
            500                 505                 510         


Asp Met Tyr Thr Asp Asn Arg Ser Arg Lys Arg Val Ser Glu Lys Asn 
        515                 520                 525             


Lys Arg Asp Phe Ser Ala Phe Lys Asp Ala Asp Asn Glu Leu Lys Val 
    530                 535                 540                 


Lys Ile Ser Pro Gln Leu Leu Leu Ala Ala His Arg Phe Leu Ala Thr 
545                 550                 555                 560 


Glu Val Ser Gln Phe Ser Pro Ser Leu Ile Ser Glu Lys Ile Leu Leu 
                565                 570                 575     


Arg Leu Leu Lys Tyr Pro Asp Val Ile Gln Glu Leu Lys Phe Asp Glu 
            580                 585                 590         


His Asn Lys Tyr Tyr Ala Arg His Tyr Leu Tyr Thr Arg Asn Lys Pro 
        595                 600                 605             


Ala Asp Tyr Phe Ile Leu Ile Leu Gln Gly Lys Val Glu Val Glu Ala 
    610                 615                 620                 


Gly Lys Glu Asn Met Lys Phe Glu Thr Gly Ala Phe Ser Tyr Tyr Gly 
625                 630                 635                 640 


Thr Met Ala Leu Thr Ser Val Pro Ser Asp Arg Ser Pro Ala His Pro 
                645                 650                 655     


Thr Pro Leu Ser Arg Ser Ala Ser Leu Ser Tyr Pro Asp Arg Thr Asp 
            660                 665                 670         


Val Ser Thr Ala Ala Thr Leu Ala Gly Ser Ser Asn Gln Phe Gly Ser 
        675                 680                 685             


Ser Val Leu Gly Gln Tyr Ile Ser Asp Phe Ser Val Arg Ala Leu Val 
    690                 695                 700                 


Asp Leu Gln Tyr Ile Lys Ile Thr Arg Gln Gln Tyr Gln Asn Gly Leu 
705                 710                 715                 720 


Leu Ala Ser Arg Met Glu Asn Ser Pro Gln Phe Pro Ile Asp Gly Cys 
                725                 730                 735     


Thr Thr His Met Glu Asn Leu Ala Glu Lys Ser Glu Leu Pro Val Val 
            740                 745                 750         


Asp Glu Thr Thr Thr Leu Leu Asn Glu Arg Asn Ser Leu Leu His Lys 
        755                 760                 765             


Ala Ser His Glu Asn Ala Ile 
    770                 775 


<210>  2347
<211>  2371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT1__Homo_sapiens__NP_001252541

<400>  2347

Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Thr Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Thr Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Thr Lys Pro Asn Phe Ile Ser Thr Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Thr Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ala Lys Thr Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Thr Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Thr His Ser Gly Leu 
    290                 295                 300                 


Thr Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Thr Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Thr Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Thr Val Ala Thr Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Thr Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Thr Ser Trp His 
                485                 490                 495     


Thr Leu Arg His Glu Leu Ile Ser Thr Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Thr Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Thr Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Thr Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Thr Leu Ala Thr Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Thr Ile Leu Thr 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Thr Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Thr Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Thr Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Thr Pro Asn Gln Thr Thr Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Thr Gly 
    770                 775                 780                 


Ser Leu Thr Gly Ile Gly Thr Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Thr Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Thr Phe Gln Gln Thr Asp Leu Ser Gln Val Trp Pro Glu Ala Asn 
            820                 825                 830         


Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala Asn Ser Tyr Phe Gln 
        835                 840                 845             


Arg Ile Tyr Asn His Pro Pro His Pro Thr Met Ser Val Asp Glu Val 
    850                 855                 860                 


Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Thr Ile Lys Arg Glu Arg 
865                 870                 875                 880 


Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe Glu Glu Tyr Arg Phe 
                885                 890                 895     


Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile Thr Ala Cys Leu Phe 
            900                 905                 910         


Gly Gly Ile Ile Glu Lys Gly Leu Val Thr Tyr Met Ala Leu Gly Leu 
        915                 920                 925             


Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys Pro Phe Gly Ser Lys 
    930                 935                 940                 


Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg Phe Lys Asn Arg Leu 
945                 950                 955                 960 


Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala Ser Ile Ser His Phe 
                965                 970                 975     


Met Gln Phe Pro His His Leu Gln Glu Tyr Ile Glu Tyr Gly Gln Gln 
            980                 985                 990         


Ser Arg Asp Pro Pro Val Lys Met  Gln Gly Ser Ile Thr  Thr Pro Gly 
        995                 1000                 1005             


Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln Ala Gln  Val Pro Ala 
    1010                 1015                 1020             


Lys Ala  Pro Leu Ala Gly Gln  Val Ser Thr Met Val  Thr Thr Ser 
    1025                 1030                 1035             


Thr Thr  Thr Thr Val Ala Lys  Thr Val Thr Val Thr  Arg Pro Thr 
    1040                 1045                 1050             


Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro Ser Ile  Asn Thr Thr 
    1055                 1060                 1065             


Asn Ile  Asp Thr Leu Leu Val  Ala Thr Asp Gln Thr  Glu Arg Ile 
    1070                 1075                 1080             


Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys Ile Ala  Phe Ile Phe 
    1085                 1090                 1095             


Asn Asn  Leu Ser Gln Ser Asn  Met Thr Gln Lys Val  Glu Glu Leu 
    1100                 1105                 1110             


Lys Glu  Thr Val Lys Glu Glu  Phe Met Pro Trp Val  Ser Gln Tyr 
    1115                 1120                 1125             


Leu Val  Met Lys Arg Val Ser  Ile Glu Pro Asn Phe  His Ser Leu 
    1130                 1135                 1140             


Tyr Ser  Asn Phe Leu Asp Thr  Leu Lys Asn Pro Glu  Phe Asn Lys 
    1145                 1150                 1155             


Met Val  Leu Asn Glu Thr Tyr  Arg Asn Ile Lys Val  Leu Leu Thr 
    1160                 1165                 1170             


Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp Arg Ser  Leu Leu Lys 
    1175                 1180                 1185             


Asn Leu  Gly His Trp Leu Gly  Met Ile Thr Leu Ala  Lys Asn Lys 
    1190                 1195                 1200             


Pro Ile  Leu His Thr Asp Leu  Asp Val Lys Ser Leu  Leu Leu Glu 
    1205                 1210                 1215             


Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu Tyr Val  Val Pro Phe 
    1220                 1225                 1230             


Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg Ser Val  Val Phe Arg 
    1235                 1240                 1245             


Pro Pro  Asn Pro Trp Thr Met  Ala Ile Met Asn Val  Leu Ala Glu 
    1250                 1255                 1260             


Leu His  Gln Glu His Asp Leu  Lys Leu Asn Leu Lys  Phe Glu Ile 
    1265                 1270                 1275             


Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp Ile Asn  Glu Leu Lys 
    1280                 1285                 1290             


Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg Leu Lys  Asn Leu Asp 
    1295                 1300                 1305             


Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val Lys Gln  Pro Glu Glu 
    1310                 1315                 1320             


Leu Pro  Pro Ile Thr Thr Thr  Thr Thr Ser Thr Thr  Pro Ala Thr 
    1325                 1330                 1335             


Asn Thr  Thr Cys Thr Ala Thr  Val Pro Pro Gln Pro  Gln Tyr Ser 
    1340                 1345                 1350             


Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala Gly Leu  Ala Pro His 
    1355                 1360                 1365             


Ile Thr  Leu Asn Pro Thr Ile  Pro Leu Phe Gln Ala  His Pro Gln 
    1370                 1375                 1380             


Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu Arg Ala  Val Gln Glu 
    1385                 1390                 1395             


Leu Val  His Pro Val Val Asp  Arg Ser Ile Lys Ile  Ala Met Thr 
    1400                 1405                 1410             


Thr Cys  Glu Gln Ile Val Arg  Lys Asp Phe Ala Leu  Asp Ser Glu 
    1415                 1420                 1425             


Glu Ser  Arg Met Arg Ile Ala  Ala His His Met Met  Arg Asn Leu 
    1430                 1435                 1440             


Thr Ala  Gly Met Ala Met Ile  Thr Cys Arg Glu Pro  Leu Leu Met 
    1445                 1450                 1455             


Ser Ile  Ser Thr Asn Leu Lys  Asn Ser Phe Ala Ser  Ala Leu Arg 
    1460                 1465                 1470             


Thr Ala  Ser Pro Gln Gln Arg  Glu Met Met Asp Gln  Ala Ala Ala 
    1475                 1480                 1485             


Gln Leu  Ala Gln Asp Asn Cys  Glu Leu Ala Cys Cys  Phe Ile Gln 
    1490                 1495                 1500             


Lys Thr  Ala Val Glu Lys Ala  Gly Pro Glu Met Asp  Lys Arg Leu 
    1505                 1510                 1515             


Ala Thr  Glu Phe Glu Leu Arg  Lys His Ala Arg Gln  Glu Gly Arg 
    1520                 1525                 1530             


Arg Tyr  Cys Asp Pro Val Val  Leu Thr Tyr Gln Ala  Glu Arg Met 
    1535                 1540                 1545             


Pro Glu  Gln Ile Arg Leu Lys  Val Gly Gly Val Asp  Pro Lys Gln 
    1550                 1555                 1560             


Leu Ala  Val Tyr Glu Glu Phe  Ala Arg Asn Val Pro  Gly Phe Leu 
    1565                 1570                 1575             


Pro Thr  Asn Asp Leu Ser Gln  Pro Thr Gly Phe Leu  Ala Gln Pro 
    1580                 1585                 1590             


Met Lys  Gln Ala Trp Ala Thr  Asp Asp Val Ala Gln  Ile Tyr Asp 
    1595                 1600                 1605             


Lys Cys  Ile Thr Glu Leu Glu  Gln His Leu His Ala  Ile Pro Pro 
    1610                 1615                 1620             


Thr Leu  Ala Met Asn Pro Gln  Ala Gln Ala Leu Arg  Ser Leu Leu 
    1625                 1630                 1635             


Glu Val  Val Val Leu Ser Arg  Asn Ser Arg Asp Ala  Ile Ala Ala 
    1640                 1645                 1650             


Leu Gly  Leu Leu Gln Lys Ala  Val Glu Gly Leu Leu  Asp Ala Thr 
    1655                 1660                 1665             


Ser Gly  Ala Asp Ala Asp Leu  Leu Leu Arg Tyr Arg  Glu Cys His 
    1670                 1675                 1680             


Leu Leu  Val Leu Lys Ala Leu  Gln Asp Gly Arg Ala  Tyr Gly Ser 
    1685                 1690                 1695             


Pro Trp  Cys Asn Lys Gln Ile  Thr Arg Cys Leu Ile  Glu Cys Arg 
    1700                 1705                 1710             


Asp Glu  Tyr Lys Tyr Asn Val  Glu Ala Val Glu Leu  Leu Ile Arg 
    1715                 1720                 1725             


Asn His  Leu Val Asn Met Gln  Gln Tyr Asp Leu His  Leu Ala Gln 
    1730                 1735                 1740             


Ser Met  Glu Asn Gly Leu Asn  Tyr Met Ala Val Ala  Phe Ala Met 
    1745                 1750                 1755             


Gln Leu  Val Lys Ile Leu Leu  Val Asp Glu Arg Ser  Val Ala His 
    1760                 1765                 1770             


Val Thr  Glu Ala Asp Leu Phe  His Thr Ile Glu Thr  Leu Met Arg 
    1775                 1780                 1785             


Ile Asn  Ala His Ser Arg Gly  Asn Ala Pro Glu Gly  Leu Pro Gln 
    1790                 1795                 1800             


Leu Met  Glu Val Val Arg Ser  Asn Tyr Glu Ala Met  Ile Asp Arg 
    1805                 1810                 1815             


Ala His  Gly Gly Pro Asn Phe  Met Met His Ser Gly  Ile Ser Gln 
    1820                 1825                 1830             


Ala Ser  Glu Tyr Asp Asp Pro  Pro Gly Leu Arg Glu  Lys Ala Glu 
    1835                 1840                 1845             


Tyr Leu  Leu Arg Glu Trp Val  Asn Leu Tyr His Ser  Ala Ala Ala 
    1850                 1855                 1860             


Gly Arg  Asp Ser Thr Lys Ala  Phe Ser Ala Phe Val  Gly Gln Met 
    1865                 1870                 1875             


His Gln  Gln Gly Ile Leu Lys  Thr Asp Asp Leu Ile  Thr Arg Phe 
    1880                 1885                 1890             


Phe Arg  Leu Cys Thr Glu Met  Cys Val Glu Ile Ser  Tyr Arg Ala 
    1895                 1900                 1905             


Gln Ala  Glu Gln Gln His Asn  Pro Ala Ala Asn Pro  Thr Met Ile 
    1910                 1915                 1920             


Arg Ala  Lys Cys Tyr His Asn  Leu Asp Ala Phe Val  Arg Leu Ile 
    1925                 1930                 1935             


Ala Leu  Leu Val Lys His Ser  Gly Glu Ala Thr Asn  Thr Val Thr 
    1940                 1945                 1950             


Lys Ile  Asn Leu Leu Asn Lys  Val Leu Gly Ile Val  Val Gly Val 
    1955                 1960                 1965             


Leu Leu  Gln Asp His Asp Val  Arg Gln Ser Glu Phe  Gln Gln Leu 
    1970                 1975                 1980             


Pro Tyr  His Arg Ile Phe Ile  Met Leu Leu Leu Glu  Leu Asn Ala 
    1985                 1990                 1995             


Pro Glu  His Val Leu Glu Thr  Ile Asn Phe Gln Thr  Leu Thr Ala 
    2000                 2005                 2010             


Phe Cys  Asn Thr Phe His Ile  Leu Arg Pro Thr Lys  Ala Pro Gly 
    2015                 2020                 2025             


Phe Val  Tyr Ala Trp Leu Glu  Leu Ile Ser His Arg  Ile Phe Ile 
    2030                 2035                 2040             


Ala Arg  Met Leu Ala His Thr  Pro Gln Gln Lys Gly  Trp Pro Met 
    2045                 2050                 2055             


Tyr Ala  Gln Leu Leu Ile Asp  Leu Phe Lys Tyr Leu  Ala Pro Phe 
    2060                 2065                 2070             


Leu Arg  Asn Val Glu Leu Thr  Lys Pro Met Gln Ile  Leu Tyr Lys 
    2075                 2080                 2085             


Gly Thr  Leu Arg Val Leu Leu  Val Leu Leu His Asp  Phe Pro Glu 
    2090                 2095                 2100             


Phe Leu  Cys Asp Tyr His Tyr  Gly Phe Cys Asp Val  Ile Pro Pro 
    2105                 2110                 2115             


Asn Cys  Ile Gln Leu Arg Asn  Leu Ile Leu Ser Ala  Phe Pro Arg 
    2120                 2125                 2130             


Asn Met  Arg Leu Pro Asp Pro  Phe Thr Pro Asn Leu  Lys Val Asp 
    2135                 2140                 2145             


Met Leu  Ser Glu Ile Asn Ile  Ala Pro Arg Ile Leu  Thr Asn Phe 
    2150                 2155                 2160             


Thr Gly  Val Met Pro Pro Gln  Phe Lys Lys Asp Leu  Asp Ser Tyr 
    2165                 2170                 2175             


Leu Lys  Thr Arg Ser Pro Val  Thr Phe Leu Ser Asp  Leu Arg Ser 
    2180                 2185                 2190             


Asn Leu  Gln Val Ser Asn Glu  Pro Gly Asn Arg Tyr  Asn Leu Gln 
    2195                 2200                 2205             


Leu Ile  Asn Ala Leu Val Leu  Tyr Val Gly Thr Gln  Ala Ile Ala 
    2210                 2215                 2220             


His Ile  His Asn Lys Gly Ser  Thr Pro Ser Met Ser  Thr Ile Thr 
    2225                 2230                 2235             


His Ser  Ala His Met Asp Ile  Phe Gln Asn Leu Ala  Val Asp Leu 
    2240                 2245                 2250             


Asp Thr  Glu Gly Arg Tyr Leu  Phe Leu Asn Ala Ile  Ala Asn Gln 
    2255                 2260                 2265             


Leu Arg  Tyr Pro Asn Ser His  Thr His Tyr Phe Ser  Cys Thr Met 
    2270                 2275                 2280             


Leu Tyr  Leu Phe Ala Glu Ala  Asn Thr Glu Ala Ile  Gln Glu Gln 
    2285                 2290                 2295             


Ile Thr  Arg Val Leu Leu Glu  Arg Leu Ile Val Asn  Arg Pro His 
    2300                 2305                 2310             


Pro Trp  Gly Leu Leu Ile Thr  Phe Ile Glu Leu Ile  Lys Asn Pro 
    2315                 2320                 2325             


Ala Phe  Lys Phe Trp Asn His  Glu Phe Val His Cys  Ala Pro Glu 
    2330                 2335                 2340             


Ile Glu  Lys Leu Phe Gln Ser  Val Ala Gln Cys Cys  Met Gly Gln 
    2345                 2350                 2355             


Lys Gln  Ala Gln Gln Val Met  Glu Gly Thr Gly Ala  Ser 
    2360                 2365                 2370     


<210>  2348
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT2__Homo_sapiens__NP_055330

<400>  2348

Met Val Arg Thr Asp Gly His Thr Leu Ser Glu Lys Arg Asn Tyr Gln 
1               5                   10                  15      


Val Thr Asn Ser Met Phe Gly Ala Ser Arg Lys Lys Phe Val Glu Gly 
            20                  25                  30          


Val Asp Ser Asp Tyr His Asp Glu Asn Met Tyr Tyr Ser Gln Ser Ser 
        35                  40                  45              


Met Phe Pro His Arg Ser Glu Lys Asp Met Leu Ala Ser Pro Ser Thr 
    50                  55                  60                  


Ser Gly Gln Leu Ser Gln Phe Gly Ala Ser Leu Tyr Gly Gln Gln Ser 
65                  70                  75                  80  


Ala Leu Gly Leu Pro Met Arg Gly Met Ser Asn Asn Thr Pro Gln Leu 
                85                  90                  95      


Asn Arg Ser Leu Ser Gln Gly Thr Gln Leu Pro Ser His Val Thr Pro 
            100                 105                 110         


Thr Thr Gly Val Pro Thr Met Ser Leu His Thr Pro Pro Ser Pro Ser 
        115                 120                 125             


Arg Gly Ile Leu Pro Met Asn Pro Arg Asn Met Met Asn His Ser Gln 
    130                 135                 140                 


Val Gly Gln Gly Ile Gly Ile Pro Ser Arg Thr Asn Ser Met Ser Ser 
145                 150                 155                 160 


Ser Gly Leu Gly Ser Pro Asn Arg Ser Ser Pro Ser Ile Ile Cys Met 
                165                 170                 175     


Pro Lys Gln Gln Pro Ser Arg Gln Pro Phe Thr Val Asn Ser Met Ser 
            180                 185                 190         


Gly Phe Gly Met Asn Arg Asn Gln Ala Phe Gly Met Asn Asn Ser Leu 
        195                 200                 205             


Ser Ser Asn Ile Phe Asn Gly Thr Asp Gly Ser Glu Asn Val Thr Gly 
    210                 215                 220                 


Leu Asp Leu Ser Asp Phe Pro Ala Leu Ala Asp Arg Asn Arg Arg Glu 
225                 230                 235                 240 


Gly Ser Gly Asn Pro Thr Pro Leu Ile Asn Pro Leu Ala Gly Arg Ala 
                245                 250                 255     


Pro Tyr Val Gly Met Val Thr Lys Pro Ala Asn Glu Gln Ser Gln Asp 
            260                 265                 270         


Phe Ser Ile His Asn Glu Asp Phe Pro Ala Leu Pro Gly Ser Ser Tyr 
        275                 280                 285             


Lys Asp Pro Thr Ser Ser Asn Asp Asp Ser Lys Ser Asn Leu Asn Thr 
    290                 295                 300                 


Ser Gly Lys Thr Thr Ser Ser Thr Asp Gly Pro Lys Phe Pro Gly Asp 
305                 310                 315                 320 


Lys Ser Ser Thr Thr Gln Asn Asn Asn Gln Gln Lys Lys Gly Ile Gln 
                325                 330                 335     


Val Leu Pro Asp Gly Arg Val Thr Asn Ile Pro Gln Gly Met Val Thr 
            340                 345                 350         


Asp Gln Phe Gly Met Ile Gly Leu Leu Thr Phe Ile Arg Ala Ala Glu 
        355                 360                 365             


Thr Asp Pro Gly Met Val His Leu Ala Leu Gly Ser Asp Leu Thr Thr 
    370                 375                 380                 


Leu Gly Leu Asn Leu Asn Ser Pro Glu Asn Leu Tyr Pro Lys Phe Ala 
385                 390                 395                 400 


Ser Pro Trp Ala Ser Ser Pro Cys Arg Pro Gln Asp Ile Asp Phe His 
                405                 410                 415     


Val Pro Ser Glu Tyr Leu Thr Asn Ile His Ile Arg Asp Lys Leu Ala 
            420                 425                 430         


Ala Ile Lys Leu Gly Arg Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr 
        435                 440                 445             


Tyr Met Asn Gly Gly Asp Val Leu Gln Leu Leu Ala Ala Val Glu Leu 
    450                 455                 460                 


Phe Asn Arg Asp Trp Arg Tyr His Lys Glu Glu Arg Val Trp Ile Thr 
465                 470                 475                 480 


Arg Ala Pro Gly Met Glu Pro Thr Met Lys Thr Asn Thr Tyr Glu Arg 
                485                 490                 495     


Gly Thr Tyr Tyr Phe Phe Asp Cys Leu Asn Trp Arg Lys Val Ala Lys 
            500                 505                 510         


Glu Phe His Leu Glu Tyr Asp Lys Leu Glu Glu Arg Pro His Leu Pro 
        515                 520                 525             


Ser Thr Phe Asn Tyr Asn Pro Ala Gln Gln Ala Phe 
    530                 535                 540 


<210>  2349
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT3__Homo_sapiens__NP_055331

<400>  2349

Met Ala Asp Lys Arg Lys Leu Gln Gly Glu Ile Asp Arg Cys Leu Lys 
1               5                   10                  15      


Lys Val Ser Glu Gly Val Glu Gln Phe Glu Asp Ile Trp Gln Lys Leu 
            20                  25                  30          


His Asn Ala Ala Asn Ala Asn Gln Lys Glu Lys Tyr Glu Ala Asp Leu 
        35                  40                  45              


Lys Lys Glu Ile Lys Lys Leu Gln Arg Leu Arg Asp Gln Ile Lys Thr 
    50                  55                  60                  


Trp Val Ala Ser Asn Glu Ile Lys Asp Lys Arg Gln Leu Ile Asp Asn 
65                  70                  75                  80  


Arg Lys Leu Ile Glu Thr Gln Met Glu Arg Phe Lys Val Val Glu Arg 
                85                  90                  95      


Glu Thr Lys Thr Lys Ala Tyr Ser Lys Glu Gly Leu Gly Leu Ala Gln 
            100                 105                 110         


Lys Val Asp Pro Ala Gln Lys Glu Lys Glu Glu Val Gly Gln Trp Leu 
        115                 120                 125             


Thr Asn Thr Ile Asp Thr Leu Asn Met Gln Val Asp Gln Phe Glu Ser 
    130                 135                 140                 


Glu Val Glu Ser Leu Ser Val Gln Thr Arg Lys Lys Lys Gly Asp Lys 
145                 150                 155                 160 


Asp Lys Gln Asp Arg Ile Glu Gly Leu Lys Arg His Ile Glu Lys His 
                165                 170                 175     


Arg Tyr His Val Arg Met Leu Glu Thr Ile Leu Arg Met Leu Asp Asn 
            180                 185                 190         


Asp Ser Ile Leu Val Asp Ala Ile Arg Lys Ile Lys Asp Asp Val Glu 
        195                 200                 205             


Tyr Tyr Val Asp Ser Ser Gln Asp Pro Asp Phe Glu Glu Asn Glu Phe 
    210                 215                 220                 


Leu Tyr Asp Asp Leu Asp Leu Glu Asp Ile Pro Gln Ala Leu Val Ala 
225                 230                 235                 240 


Thr Ser Pro Pro Ser His Ser His Met Glu Asp Glu Ile Phe Asn Gln 
                245                 250                 255     


Ser Ser Ser Thr Pro Thr Ser Thr Thr Ser Ser Ser Pro Ile Pro Pro 
            260                 265                 270         


Ser Pro Ala Asn Cys Thr Thr Glu Asn Ser Glu Asp Asp Lys Lys Arg 
        275                 280                 285             


Gly Arg Ser Thr Asp Ser Glu Val Ser Gln Ser Pro Ala Lys Asn Gly 
    290                 295                 300                 


Ser Lys Pro Val His Ser Asn Gln His Pro Gln Ser Pro Ala Val Pro 
305                 310                 315                 320 


Pro Thr Tyr Pro Ser Gly Pro Pro Pro Ala Ala Ser Ala Leu Ser Thr 
                325                 330                 335     


Thr Pro Gly Asn Asn Gly Val Pro Ala Pro Ala Ala Pro Pro Ser Ala 
            340                 345                 350         


Leu Gly Pro Lys Ala Ser Pro Ala Pro Ser His Asn Ser Gly Thr Pro 
        355                 360                 365             


Ala Pro Tyr Ala Gln Ala Val Ala Pro Pro Ala Pro Ser Gly Pro Ser 
    370                 375                 380                 


Thr Thr Gln Pro Arg Pro Pro Ser Val Gln Pro Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Ser Ser Asn Ser Ser Ala 
                405                 410                 415     


Gly Gly Gly Ala Gly Lys Gln Asn Gly Ala Thr Ser Tyr Ser Ser Val 
            420                 425                 430         


Val Ala Asp Ser Pro Ala Glu Val Ala Leu Ser Ser Ser Gly Gly Asn 
        435                 440                 445             


Asn Ala Ser Ser Gln Ala Leu Gly Pro Pro Ser Gly Pro His Asn Pro 
    450                 455                 460                 


Pro Pro Ser Thr Ser Lys Glu Pro Ser Ala Ala Ala Pro Thr Gly Ala 
465                 470                 475                 480 


Gly Gly Val Ala Pro Gly Ser Gly Asn Asn Ser Gly Gly Pro Ser Leu 
                485                 490                 495     


Leu Val Pro Leu Pro Val Asn Pro Pro Ser Ser Pro Thr Pro Ser Phe 
            500                 505                 510         


Ser Asp Ala Lys Ala Ala Gly Ala Leu Leu Asn Gly Pro Pro Gln Phe 
        515                 520                 525             


Ser Thr Ala Pro Glu Ile Lys Ala Pro Glu Pro Leu Ser Ser Leu Lys 
    530                 535                 540                 


Ser Met Ala Glu Arg Ala Ala Ile Ser Ser Gly Ile Glu Asp Pro Val 
545                 550                 555                 560 


Pro Thr Leu His Leu Thr Glu Arg Asp Ile Ile Leu Ser Ser Thr Ser 
                565                 570                 575     


Ala Pro Pro Ala Ser Ala Gln Pro Pro Leu Gln Leu Ser Glu Val Asn 
            580                 585                 590         


Ile Pro Leu Ser Leu Gly Val Cys Pro Leu Gly Pro Val Pro Leu Thr 
        595                 600                 605             


Lys Glu Gln Leu Tyr Gln Gln Ala Met Glu Glu Ala Ala Trp His His 
    610                 615                 620                 


Met Pro His Pro Ser Asp Ser Glu Arg Ile Arg Gln Tyr Leu Pro Arg 
625                 630                 635                 640 


Asn Pro Cys Pro Thr Pro Pro Tyr His His Gln Met Pro Pro Pro His 
                645                 650                 655     


Ser Asp Thr Val Glu Phe Tyr Gln Arg Leu Ser Thr Glu Thr Leu Phe 
            660                 665                 670         


Phe Ile Phe Tyr Tyr Leu Glu Gly Thr Lys Ala Gln Tyr Leu Ala Ala 
        675                 680                 685             


Lys Ala Leu Lys Lys Gln Ser Trp Arg Phe His Thr Lys Tyr Met Met 
    690                 695                 700                 


Trp Phe Gln Arg His Glu Glu Pro Lys Thr Ile Thr Asp Glu Phe Glu 
705                 710                 715                 720 


Gln Gly Thr Tyr Ile Tyr Phe Asp Tyr Glu Lys Trp Gly Gln Arg Lys 
                725                 730                 735     


Lys Glu Gly Phe Thr Phe Glu Tyr Arg Tyr Leu Glu Asp Arg Asp Leu 
            740                 745                 750         


Gln 
    


<210>  2350
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT4__Homo_sapiens__NP_001008226

<400>  2350

Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Thr 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Thr Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile Lys Asn 
65                  70                  75                  80  


Glu Lys Lys Gln Lys Gln Asn Glu Arg Lys Gln Lys Ile Ser Glu Asn 
                85                  90                  95      


Arg Lys His Leu Ala Ser Val Arg Val Val Gln Lys Asn Leu Val Phe 
            100                 105                 110         


Val Val Gly Leu Ser Gln Arg Leu Ala Asp Pro Glu Val Leu Lys Arg 
        115                 120                 125             


Pro Glu Tyr Phe Gly Lys Phe Gly Lys Ile His Lys Val Val Ile Asn 
    130                 135                 140                 


Asn Ser Thr Ser Tyr Ala Gly Ser Gln Gly Pro Ser Ala Ser Ala Tyr 
145                 150                 155                 160 


Val Thr Tyr Ile Arg Ser Glu Asp Ala Leu Arg Ala Ile Gln Cys Val 
                165                 170                 175     


Asn Asn Val Val Val Asp Gly Arg Thr Leu Lys Ala Ser Leu Gly Thr 
            180                 185                 190         


Thr Lys Tyr Cys Ser Tyr Phe Leu Lys Asn Met Gln Cys Pro Lys Pro 
        195                 200                 205             


Asp Cys Met Tyr Leu His Glu Leu Gly Asp Glu Ala Ala Ser Phe Thr 
    210                 215                 220                 


Lys Glu Glu Met Gln Ala Gly Lys His Gln Glu Tyr Glu Gln Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Tyr Lys Leu Asn Pro Asn Phe Leu Gln Leu Ser Thr 
                245                 250                 255     


Gly Ser Val Asp Lys Asn Lys Asn Lys Val Thr Pro Leu Gln Ser Pro 
            260                 265                 270         


Ile Asp Lys Pro Ser Asp Ser Leu Ser Ile Gly Asn Gly Asp Asn Ser 
        275                 280                 285             


Gln Gln Ile Ser Asn Ser Asp Thr Pro Ser Pro Pro Pro Gly Leu Ser 
    290                 295                 300                 


Lys Ser Asn Pro Val Ile Pro Ile Ser Ser Ser Asn His Ser Ala Arg 
305                 310                 315                 320 


Ser Pro Phe Glu Gly Ala Val Thr Glu Ser Gln Ser Leu Phe Ser Asp 
                325                 330                 335     


Asn Phe Arg His Pro Asn Pro Ile Pro Ser Gly Leu Pro Pro Phe Pro 
            340                 345                 350         


Ser Ser Pro Gln Thr Ser Ser Asp Trp Pro Thr Ala Pro Glu Pro Gln 
        355                 360                 365             


Ser Leu Phe Thr Ser Glu Thr Ile Pro Val Ser Ser Ser Thr Asp Trp 
    370                 375                 380                 


Gln Ala Ala Phe Gly Phe Gly Ser Ser Lys Gln Pro Glu Asp Asp Leu 
385                 390                 395                 400 


Gly Phe Asp Pro Phe Asp Val Thr Arg Lys Ala Leu Ala Asp Leu Ile 
                405                 410                 415     


Glu Lys Glu Leu Ser Val Gln Asp Gln Pro Ser Leu Ser Pro Thr Ser 
            420                 425                 430         


Leu Gln Asn Ser Ser Ser His Thr Thr Thr Ala Lys Gly Pro Gly Ser 
        435                 440                 445             


Gly Phe Leu His Pro Ala Ala Ala Thr Asn Ala Asn Ser Leu Asn Ser 
    450                 455                 460                 


Thr Phe Ser Val Leu Pro Gln Arg Phe Pro Gln Phe Gln Gln His Arg 
465                 470                 475                 480 


Ala Val Tyr Asn Ser Phe Ser Phe Pro Gly Gln Ala Ala Arg Tyr Pro 
                485                 490                 495     


Trp Met Ala Phe Pro Arg Asn Ser Ile Met His Leu Asn His Thr Ala 
            500                 505                 510         


Asn Pro Thr Ser Asn Ser Asn Phe Leu Asp Leu Asn Leu Pro Pro Gln 
        515                 520                 525             


His Asn Thr Gly Leu Gly Gly Ile Pro Val Ala Gly Glu Glu Glu Val 
    530                 535                 540                 


Lys Val Ser Thr Met Pro Leu Ser Thr Ser Ser His Ser Leu Gln Gln 
545                 550                 555                 560 


Gly Gln Gln Pro Thr Ser Leu His Thr Thr Val Ala 
                565                 570         


<210>  2351
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT6__Homo_sapiens__NP_001290170

<400>  2351

Met Pro Lys Glu Lys Tyr Glu Pro Pro Asp Pro Arg Arg Met Tyr Thr 
1               5                   10                  15      


Ile Met Ser Ser Glu Glu Ala Ala Asn Gly Lys Lys Ser His Trp Ala 
            20                  25                  30          


Glu Leu Glu Ile Ser Gly Lys Val Arg Ser Leu Ser Ala Ser Leu Trp 
        35                  40                  45              


Ser Leu Thr His Leu Thr Ala Leu His Leu Ser Asp Asn Ser Leu Ser 
    50                  55                  60                  


Arg Ile Pro Ser Asp Ile Ala Lys Leu His Asn Leu Val Tyr Leu Asp 
65                  70                  75                  80  


Leu Ser Ser Asn Lys Ile Arg Ser Leu Pro Ala Glu Leu Gly Asn Met 
                85                  90                  95      


Val Ser Leu Arg Glu Leu His Leu Asn Asn Asn Leu Leu Arg Val Leu 
            100                 105                 110         


Pro Phe Glu Leu Gly Lys Leu Phe Gln Leu Gln Thr Leu Gly Leu Lys 
        115                 120                 125             


Gly Asn Pro Leu Thr Gln Asp Ile Leu Asn Leu Tyr Gln Glu Pro Asp 
    130                 135                 140                 


Gly Thr Arg Arg Leu Leu Asn Tyr Leu Leu Asp Asn Leu Ser Gly Thr 
145                 150                 155                 160 


Ala Lys Arg Ile Thr Thr Glu Gln Pro Pro Pro Arg Ser Trp Ile Met 
                165                 170                 175     


Leu Gln Glu Pro Asp Arg Thr Arg Pro Thr Ala Leu Phe Ser Val Met 
            180                 185                 190         


Cys Tyr Asn Val Leu Cys Asp Lys Tyr Ala Thr Arg Gln Leu Tyr Gly 
        195                 200                 205             


Tyr Cys Pro Ser Trp Ala Leu Asn Trp Asp Tyr Arg Lys Lys Ala Ile 
    210                 215                 220                 


Ile Gln Glu Ile Leu Ser Cys Asn Ala Asp Ile Val Ser Leu Gln Glu 
225                 230                 235                 240 


Val Glu Thr Glu Gln Tyr Tyr Ser Phe Phe Leu Val Glu Leu Lys Glu 
                245                 250                 255     


Arg Gly Tyr Asn Gly Phe Phe Ser Pro Lys Ser Arg Ala Arg Thr Met 
            260                 265                 270         


Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys 
        275                 280                 285             


Thr Glu Lys Phe Thr Leu Val Gln Lys His Thr Val Glu Phe Asn Gln 
    290                 295                 300                 


Leu Ala Met Ala Asn Ser Glu Gly Ser Glu Ala Met Leu Asn Arg Val 
305                 310                 315                 320 


Met Thr Lys Asp Asn Ile Gly Val Ala Val Leu Leu Glu Leu Arg Lys 
                325                 330                 335     


Glu Ser Ile Glu Met Pro Ser Gly Lys Pro His Leu Gly Thr Glu Lys 
            340                 345                 350         


Gln Leu Ile Leu Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr 
        355                 360                 365             


Ser Asp Val Lys Leu Val Gln Thr Met Met Phe Leu Ser Glu Val Lys 
    370                 375                 380                 


Asn Ile Ile Asp Lys Ala Ser Arg Asn Leu Lys Ser Ser Val Leu Gly 
385                 390                 395                 400 


Glu Phe Gly Thr Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu 
                405                 410                 415     


Pro Asp Ser Gly Val Val Glu Tyr Leu Ser Thr Gly Gly Val Glu Thr 
            420                 425                 430         


Asn His Lys Asp Phe Lys Glu Leu Arg Tyr Asn Glu Ser Leu Thr Asn 
        435                 440                 445             


Phe Ser Cys His Gly Lys Asn Gly Thr Thr Asn Gly Arg Ile Thr His 
    450                 455                 460                 


Gly Phe Lys Leu Gln Ser Ala Tyr Glu Ser Gly Leu Met Pro Tyr Thr 
465                 470                 475                 480 


Asn Tyr Thr Phe Asp Phe Lys Gly Ile Ile Asp Tyr Ile Phe Tyr Ser 
                485                 490                 495     


Lys Pro Gln Leu Asn Thr Leu Gly Ile Leu Gly Pro Leu Asp His His 
            500                 505                 510         


Trp Leu Val Glu Asn Asn Ile Ser Gly Cys Pro His Pro Leu Ile Pro 
        515                 520                 525             


Ser Asp His Phe Ser Leu Phe Ala Gln Leu Glu Leu Leu Leu Pro Phe 
    530                 535                 540                 


Leu Pro Gln Val Asn Gly Ile His Leu Pro Gly Arg Arg 
545                 550                 555         


<210>  2352
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT6L__Homo_sapiens__NP_653172

<400>  2352

Met Arg Leu Ile Gly Met Pro Lys Glu Lys Tyr Asp Pro Pro Asp Pro 
1               5                   10                  15      


Arg Arg Ile Tyr Thr Ile Met Ser Ala Glu Glu Val Ala Asn Gly Lys 
            20                  25                  30          


Lys Ser His Trp Ala Glu Leu Glu Ile Ser Gly Arg Val Arg Ser Leu 
        35                  40                  45              


Ser Thr Ser Leu Trp Ser Leu Thr His Leu Thr Ala Leu His Leu Asn 
    50                  55                  60                  


Asp Asn Tyr Leu Ser Arg Ile Pro Pro Asp Ile Ala Lys Leu His Asn 
65                  70                  75                  80  


Leu Val Tyr Leu Asp Leu Ser Ser Asn Lys Leu Arg Ser Leu Pro Ala 
                85                  90                  95      


Glu Leu Gly Asn Met Val Ser Leu Arg Glu Leu Leu Leu Asn Asn Asn 
            100                 105                 110         


Leu Leu Arg Val Leu Pro Tyr Glu Leu Gly Arg Leu Phe Gln Leu Gln 
        115                 120                 125             


Thr Leu Gly Leu Lys Gly Asn Pro Leu Ser Gln Asp Ile Leu Asn Leu 
    130                 135                 140                 


Tyr Gln Asp Pro Asp Gly Thr Arg Lys Leu Leu Asn Phe Met Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Val His Pro Glu Gln Leu Pro Pro Arg Pro Trp Ile Thr 
                165                 170                 175     


Leu Lys Glu Arg Asp Gln Ile Leu Pro Ser Ala Ser Phe Thr Val Met 
            180                 185                 190         


Cys Tyr Asn Val Leu Cys Asp Lys Tyr Ala Thr Arg Gln Leu Tyr Gly 
        195                 200                 205             


Tyr Cys Pro Ser Trp Ala Leu Asn Trp Glu Tyr Arg Lys Lys Gly Ile 
    210                 215                 220                 


Met Glu Glu Ile Val Asn Cys Asp Ala Asp Ile Ile Ser Leu Gln Glu 
225                 230                 235                 240 


Val Glu Thr Glu Gln Tyr Phe Thr Leu Phe Leu Pro Ala Leu Lys Glu 
                245                 250                 255     


Arg Gly Tyr Asp Gly Phe Phe Ser Pro Lys Ser Arg Ala Lys Ile Met 
            260                 265                 270         


Ser Glu Gln Glu Arg Lys His Val Asp Gly Cys Ala Ile Phe Phe Lys 
        275                 280                 285             


Thr Glu Lys Phe Thr Leu Val Gln Lys His Thr Val Glu Phe Asn Gln 
    290                 295                 300                 


Val Ala Met Ala Asn Ser Asp Gly Ser Glu Ala Met Leu Asn Arg Val 
305                 310                 315                 320 


Met Thr Lys Asp Asn Ile Gly Val Ala Val Val Leu Glu Val His Lys 
                325                 330                 335     


Glu Leu Phe Gly Ala Gly Met Lys Pro Ile His Ala Ala Asp Lys Gln 
            340                 345                 350         


Leu Leu Ile Val Ala Asn Ala His Met His Trp Asp Pro Glu Tyr Ser 
        355                 360                 365             


Asp Val Lys Leu Ile Gln Thr Met Met Phe Val Ser Glu Val Lys Asn 
    370                 375                 380                 


Ile Leu Glu Lys Ala Ser Ser Arg Pro Gly Ser Pro Thr Ala Asp Pro 
385                 390                 395                 400 


Asn Ser Ile Pro Leu Val Leu Cys Ala Asp Leu Asn Ser Leu Pro Asp 
                405                 410                 415     


Ser Gly Val Val Glu Tyr Leu Ser Asn Gly Gly Val Ala Asp Asn His 
            420                 425                 430         


Lys Asp Phe Lys Glu Leu Arg Tyr Asn Glu Cys Leu Met Asn Phe Ser 
        435                 440                 445             


Cys Asn Gly Lys Asn Gly Ser Ser Glu Gly Arg Ile Thr His Gly Phe 
    450                 455                 460                 


Gln Leu Lys Ser Ala Tyr Glu Asn Asn Leu Met Pro Tyr Thr Asn Tyr 
465                 470                 475                 480 


Thr Phe Asp Phe Lys Gly Val Ile Asp Tyr Ile Phe Tyr Ser Lys Thr 
                485                 490                 495     


His Met Asn Val Leu Gly Val Leu Gly Pro Leu Asp Pro Gln Trp Leu 
            500                 505                 510         


Val Glu Asn Asn Ile Thr Gly Cys Pro His Pro His Ile Pro Ser Asp 
        515                 520                 525             


His Phe Ser Leu Leu Thr Gln Leu Glu Leu His Pro Pro Leu Leu Pro 
    530                 535                 540                 


Leu Val Asn Gly Val His Leu Pro Asn Arg Arg 
545                 550                 555 


<210>  2353
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT7__Homo_sapiens__NP_037486

<400>  2353

Met Pro Ala Ala Thr Val Asp His Ser Gln Arg Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Cys Asn Leu Asp Glu Glu Met Lys Lys Ile Arg Gln Val Ile Arg 
            20                  25                  30          


Lys Tyr Asn Tyr Val Ala Met Asp Thr Glu Phe Pro Gly Val Val Ala 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Asn Ala Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Thr 
65                  70                  75                  80  


Phe Met Asn Glu Gln Gly Glu Tyr Pro Pro Gly Thr Ser Thr Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Thr Glu Asp Met Tyr Ala Gln Asp Ser 
            100                 105                 110         


Ile Glu Leu Leu Thr Thr Ser Gly Ile Gln Phe Lys Lys His Glu Glu 
        115                 120                 125             


Glu Gly Ile Glu Thr Gln Tyr Phe Ala Glu Leu Leu Met Thr Ser Gly 
    130                 135                 140                 


Val Val Leu Cys Glu Gly Val Lys Trp Leu Ser Phe His Ser Gly Tyr 
145                 150                 155                 160 


Asp Phe Gly Tyr Leu Ile Lys Ile Leu Thr Asn Ser Asn Leu Pro Glu 
                165                 170                 175     


Glu Glu Leu Asp Phe Phe Glu Ile Leu Arg Leu Phe Phe Pro Val Ile 
            180                 185                 190         


Tyr Asp Val Lys Tyr Leu Met Lys Ser Cys Lys Asn Leu Lys Gly Gly 
        195                 200                 205             


Leu Gln Glu Val Ala Glu Gln Leu Glu Leu Glu Arg Ile Gly Pro Gln 
    210                 215                 220                 


His Gln Ala Gly Ser Asp Ser Leu Leu Thr Gly Met Ala Phe Phe Lys 
225                 230                 235                 240 


Met Arg Glu Met Phe Phe Glu Asp His Ile Asp Asp Ala Lys Tyr Cys 
                245                 250                 255     


Gly His Leu Tyr Gly Leu Gly Ser Gly Ser Ser Tyr Val Gln Asn Gly 
            260                 265                 270         


Thr Gly Asn Ala Tyr Glu Glu Glu Ala Asn Lys Gln Ser 
        275                 280                 285 


<210>  2354
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT8__Homo_sapiens__NP_001288003

<400>  2354

Met Pro Ala Ala Leu Val Glu Asn Ser Gln Val Ile Cys Glu Val Trp 
1               5                   10                  15      


Ala Ser Asn Leu Glu Glu Glu Met Arg Lys Ile Arg Glu Ile Val Leu 
            20                  25                  30          


Ser Tyr Ser Tyr Ile Ala Met Asp Thr Glu Phe Pro Gly Val Val Val 
        35                  40                  45              


Arg Pro Ile Gly Glu Phe Arg Ser Ser Ile Asp Tyr Gln Tyr Gln Leu 
    50                  55                  60                  


Leu Arg Cys Asn Val Asp Leu Leu Lys Ile Ile Gln Leu Gly Leu Thr 
65                  70                  75                  80  


Phe Thr Asn Glu Lys Gly Glu Tyr Pro Ser Gly Ile Asn Thr Trp Gln 
                85                  90                  95      


Phe Asn Phe Lys Phe Asn Leu Thr Gly Tyr Asp Phe Gly Tyr Met Val 
            100                 105                 110         


Lys Leu Leu Thr Asp Ser Arg Leu Pro Glu Glu Glu His Glu Phe Phe 
        115                 120                 125             


His Ile Leu Asn Leu Phe Phe Pro Ser Ile Tyr Asp Val Lys Tyr Leu 
    130                 135                 140                 


Met Lys Ser Cys Lys Asn Leu Lys Gly Gly Leu Gln Glu Val Ala Asp 
145                 150                 155                 160 


Gln Leu Asp Leu Gln Arg Ile Gly Arg Gln His Gln Ala Gly Ser Asp 
                165                 170                 175     


Ser Leu Leu Thr Gly Met Ala Phe Phe Arg Met Lys Glu Leu Phe Phe 
            180                 185                 190         


Glu Asp Ser Ile Asp Asp Ala Lys Tyr Cys Gly Arg Leu Tyr Gly Leu 
        195                 200                 205             


Gly Thr Gly Val Ala Gln Lys Gln Asn Glu Asp Val Asp Ser Ala Gln 
    210                 215                 220                 


Glu Lys Met Ser Ile Leu Ala Ile Ile Asn Asn Met Gln Gln 
225                 230                 235             


<210>  2355
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP__Homo_sapiens__NP_149124

<400>  2355

Met Asn Arg Gly Phe Ser Arg Lys Ser His Thr Phe Leu Pro Lys Ile 
1               5                   10                  15      


Phe Phe Arg Lys Met Ser Ser Ser Gly Ala Lys Asp Lys Pro Glu Leu 
            20                  25                  30          


Gln Phe Pro Phe Leu Gln Asp Glu Asp Thr Val Ala Thr Leu Leu Glu 
        35                  40                  45              


Cys Lys Thr Leu Phe Ile Leu Arg Gly Leu Pro Gly Ser Gly Lys Ser 
    50                  55                  60                  


Thr Leu Ala Arg Val Ile Val Asp Lys Tyr Arg Asp Gly Thr Lys Met 
65                  70                  75                  80  


Val Ser Ala Asp Ala Tyr Lys Ile Thr Pro Gly Ala Arg Gly Ala Phe 
                85                  90                  95      


Ser Glu Glu Tyr Lys Arg Leu Asp Glu Asp Leu Ala Ala Tyr Cys Arg 
            100                 105                 110         


Arg Arg Asp Ile Arg Ile Leu Val Leu Asp Asp Thr Asn His Glu Arg 
        115                 120                 125             


Glu Arg Leu Glu Gln Leu Phe Glu Met Ala Asp Gln Tyr Gln Tyr Gln 
    130                 135                 140                 


Val Val Leu Val Glu Pro Lys Thr Ala Trp Arg Leu Asp Cys Ala Gln 
145                 150                 155                 160 


Leu Lys Glu Lys Asn Gln Trp Gln Leu Ser Ala Asp Asp Leu Lys Lys 
                165                 170                 175     


Leu Lys Pro Gly Leu Glu Lys Asp Phe Leu Pro Leu Tyr Phe Gly Trp 
            180                 185                 190         


Phe Leu Thr Lys Lys Ser Ser Glu Thr Leu Arg Lys Ala Gly Gln Val 
        195                 200                 205             


Phe Leu Glu Glu Leu Gly Asn His Lys Ala Phe Lys Lys Glu Leu Arg 
    210                 215                 220                 


Gln Phe Val Pro Gly Asp Glu Pro Arg Glu Lys Met Asp Leu Val Thr 
225                 230                 235                 240 


Tyr Phe Gly Lys Arg Pro Pro Gly Val Leu His Cys Thr Thr Lys Phe 
                245                 250                 255     


Cys Asp Tyr Gly Lys Ala Pro Gly Ala Glu Glu Tyr Ala Gln Gln Asp 
            260                 265                 270         


Val Leu Lys Lys Ser Tyr Ser Lys Ala Phe Thr Leu Thr Ile Ser Ala 
        275                 280                 285             


Leu Phe Val Thr Pro Lys Thr Thr Gly Ala Arg Val Glu Leu Ser Glu 
    290                 295                 300                 


Gln Gln Leu Gln Leu Trp Pro Ser Asp Val Asp Lys Leu Ser Pro Thr 
305                 310                 315                 320 


Asp Asn Leu Pro Arg Gly Ser Arg Ala His Ile Thr Leu Gly Cys Ala 
                325                 330                 335     


Ala Asp Val Glu Ala Val Gln Thr Gly Leu Asp Leu Leu Glu Ile Leu 
            340                 345                 350         


Arg Gln Glu Lys Gly Gly Ser Arg Gly Glu Glu Val Gly Glu Leu Ser 
        355                 360                 365             


Arg Gly Lys Leu Tyr Ser Leu Gly Asn Gly Arg Trp Met Leu Thr Leu 
    370                 375                 380                 


Ala Lys Asn Met Glu Val Arg Ala Ile Phe Thr Gly Tyr Tyr Gly Lys 
385                 390                 395                 400 


Gly Lys Pro Val Pro Thr Gln Gly Ser Arg Lys Gly Gly Ala Leu Gln 
                405                 410                 415     


Ser Cys Thr Ile Ile 
            420     


<210>  2356
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNPY2__Homo_sapiens__NP_055070

<400>  2356

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Thr Glu 
65                  70                  75                  80  


Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      


Asp Pro Ser Thr His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         


Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             


Ile Ser Gly Thr Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 


Asp Lys Leu Cys Ser Lys Arg Thr Asp Leu Cys Asp His Ala Leu His 
                165                 170                 175     


Ile Ser His Asp Glu Leu 
            180         


<210>  2357
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNPY3__Homo_sapiens__NP_006577

<400>  2357

Met Asp Ser Met Pro Glu Pro Ala Ser Arg Cys Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Ala Pro Glu Leu Gly Pro 
            20                  25                  30          


Ser Gln Ala Gly Ala Glu Glu Asn Asp Trp Val Arg Leu Pro Ser Lys 
        35                  40                  45              


Cys Glu Val Cys Lys Tyr Val Ala Val Glu Leu Lys Ser Ala Phe Glu 
    50                  55                  60                  


Glu Thr Gly Lys Thr Lys Glu Val Ile Gly Thr Gly Tyr Gly Ile Leu 
65                  70                  75                  80  


Asp Gln Lys Ala Ser Gly Val Lys Tyr Thr Lys Ser Asp Leu Arg Leu 
                85                  90                  95      


Ile Glu Val Thr Glu Thr Ile Cys Lys Arg Leu Leu Asp Tyr Ser Leu 
            100                 105                 110         


His Lys Glu Arg Thr Gly Ser Asn Arg Phe Ala Lys Gly Met Ser Glu 
        115                 120                 125             


Thr Phe Glu Thr Leu His Asn Leu Val His Lys Gly Val Lys Val Val 
    130                 135                 140                 


Met Asp Ile Pro Tyr Glu Leu Trp Asn Glu Thr Ser Ala Glu Val Ala 
145                 150                 155                 160 


Asp Leu Lys Lys Gln Cys Asp Val Leu Val Glu Glu Phe Glu Glu Val 
                165                 170                 175     


Ile Glu Asp Trp Tyr Arg Asn His Gln Glu Glu Asp Leu Thr Glu Phe 
            180                 185                 190         


Leu Cys Ala Asn His Val Leu Lys Gly Lys Asp Thr Ser Cys Leu Ala 
        195                 200                 205             


Glu Gln Trp Ser Gly Lys Lys Gly Asp Thr Ala Ala Leu Gly Gly Lys 
    210                 215                 220                 


Lys Ser Lys Lys Lys Ser Ser Arg Ala Lys Ala Ala Gly Gly Arg Ser 
225                 230                 235                 240 


Ser Ser Ser Lys Gln Arg Lys Glu Leu Gly Gly Leu Glu Gly Asp Pro 
                245                 250                 255     


Ser Pro Glu Glu Asp Glu Gly Ile Gln Lys Ala Ser Pro Leu Thr His 
            260                 265                 270         


Ser Pro Pro Asp Glu Leu 
        275             


<210>  2358
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNR1__Homo_sapiens__NP_001153731

<400>  2358

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  2359
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNR2__Homo_sapiens__XP_011538931

<400>  2359

Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly 
1               5                   10                  15      


Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln 
            20                  25                  30          


Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala 
        35                  40                  45              


Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu 
    50                  55                  60                  


Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp 
65                  70                  75                  80  


Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val 
                85                  90                  95      


Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser 
            100                 105                 110         


Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala 
        115                 120                 125             


Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu 
    130                 135                 140                 


Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu 
145                 150                 155                 160 


Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro 
                165                 170                 175     


Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu 
            180                 185                 190         


Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr 
        195                 200                 205             


Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser 
    210                 215                 220                 


Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp 
225                 230                 235                 240 


Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile 
                245                 250                 255     


Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr 
            260                 265                 270         


Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys 
        275                 280                 285             


Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly 
    290                 295                 300                 


Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys 
305                 310                 315                 320 


Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser 
                325                 330                 335     


Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser 
            340                 345                 350         


Arg Asp Leu Asp Leu Ser Asp Cys 
        355                 360 


<210>  2360
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNRIP1__Homo_sapiens__NP_001104571

<400>  2360

Met Gly Asp Leu Pro Gly Leu Val Arg Leu Ser Ile Ala Leu Arg Ile 
1               5                   10                  15      


Gln Pro Asn Asp Gly Pro Val Phe Tyr Lys Val Asp Gly Gln Arg Phe 
            20                  25                  30          


Gly Gln Asn Arg Thr Ile Lys Leu Leu Thr Gly Ser Ser Tyr Lys Val 
        35                  40                  45              


Glu Val Lys Ile Lys Pro Ser Thr Leu Gln Val Glu Asn Ile Ser Ile 
    50                  55                  60                  


Gly Gly Val Leu Val Pro Leu Glu Leu Lys Ser Lys Glu Pro Asp Gly 
65                  70                  75                  80  


Asp Arg Val Val Tyr Thr Gly Thr Tyr Asp Thr Glu Gly Val Thr Pro 
                85                  90                  95      


Thr Lys Ser Gly Glu Arg Gln Pro Ile Gln Ile Thr Met Pro Glu Cys 
            100                 105                 110         


Leu Glu Gln Arg Pro Gln Glu Ile Ser Leu Thr Tyr Glu Cys Glu Glu 
        115                 120                 125             


<210>  2361
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNST__Homo_sapiens__NP_001132931

<400>  2361

Met Asp Asp Ser Asp Thr Pro Thr Tyr Tyr Leu Gln Ile Glu Pro Gln 
1               5                   10                  15      


Asp Gly Cys His Pro Gly Asp Ser Val Glu Arg Ser Val Thr Cys Leu 
            20                  25                  30          


Pro Ser Ala Ser Asp Glu Asn Glu Asn Gln Leu Asp Gly Asp Gly His 
        35                  40                  45              


Glu His Leu Thr Ser Ser Asp Ser Ala Met Gly Lys Pro Gln Val Ser 
    50                  55                  60                  


Glu Gln Asp Ser Leu Asn Asn Asn Glu Ser Cys Thr Leu Ser Cys Glu 
65                  70                  75                  80  


Val Ala Ala Gly Glu Asn Leu Gln Asn Thr Leu Cys Glu Ala Ser Arg 
                85                  90                  95      


Asp Glu Gln Ala Phe Leu Gly Lys Asp Lys Lys Ile Pro Gly Lys Arg 
            100                 105                 110         


Ser Pro Arg Ser Lys Lys Gly Thr Ala Lys Lys Ile Pro Pro Gly Leu 
        115                 120                 125             


Phe Ser Gly Asp Ile Ala Pro Leu Met Gln Glu Lys Val Leu Ser Ala 
    130                 135                 140                 


Val Thr Tyr Ala Val Asp Asp Glu Glu Ala Ala Glu Val Asn Ala Asn 
145                 150                 155                 160 


Glu Gln Pro Glu Ala Pro Lys Leu Val Leu Gln Ser Leu Phe Ser Leu 
                165                 170                 175     


Ile Arg Gly Glu Val Glu Gln Leu Asp Ser Arg Ala Leu Pro Leu Cys 
            180                 185                 190         


Leu His Gln Ile Ala Glu Ser Tyr Phe Gln Glu Glu Asp Tyr Glu Lys 
        195                 200                 205             


Ala Met Lys Phe Ile Gln Leu Glu Arg Leu Tyr His Glu Gln Leu Leu 
    210                 215                 220                 


Ala Asn Leu Ser Ala Ile Gln Glu Gln Trp Glu Thr Lys Trp Lys Thr 
225                 230                 235                 240 


Val Gln Pro His Thr Val Thr Ala Leu Arg Asn Ser Glu Lys Gly Phe 
                245                 250                 255     


Asn Gly Glu Asp Phe Glu Arg Leu Thr Lys Ile Cys Ala Thr His Gln 
            260                 265                 270         


Asp Pro Leu Leu Ser Lys His Lys Ile Ala Ala Val Glu Lys Ser Gln 
        275                 280                 285             


Glu Arg Lys Cys Ser Thr Gln Leu Leu Val Ser Glu Asp Pro Lys Glu 
    290                 295                 300                 


Gly Gly Ala Thr Thr Lys Glu Ser Glu Ser Lys Thr Cys Leu Gly Thr 
305                 310                 315                 320 


Glu Ser Ser Lys Glu Ser Gln His Thr Val Glu Pro Leu Gly Ser Ser 
                325                 330                 335     


Pro Cys Cys His Gln Met Asp Val Gln Thr Asp Ser Pro Ser Leu Ser 
            340                 345                 350         


Val Thr Ala Gly Lys Asp His Met Glu Glu Leu Leu Cys Ser Ala Glu 
        355                 360                 365             


Ala Thr Leu Ala Leu His Thr Gln Ser Ser Glu Thr Ala Gly Ser Pro 
    370                 375                 380                 


Ser Gly Pro Asp Ser Ser Glu Asp Ala Cys Glu Asp Asp Ser Arg Leu 
385                 390                 395                 400 


Gln Leu Ala Gln Thr Glu Ala Cys Gln Asp Val Ala Arg Ile Glu Gly 
                405                 410                 415     


Ile Ala Glu Asp Pro Lys Val Phe Leu Ser Ser Lys Ser Lys Thr Glu 
            420                 425                 430         


Pro Leu Ile Ser Pro Gly Cys Asp Arg Ile Pro Pro Ala Leu Ile Ser 
        435                 440                 445             


Glu Gly Lys Tyr Ser Gln Ala Gln Arg Lys Glu Leu Arg Leu Pro Leu 
    450                 455                 460                 


Arg Asp Ala Ser Glu Ala Leu Pro Thr Asp Gln Leu Glu Asn Asn Glu 
465                 470                 475                 480 


Leu Asn Glu Leu Gln Gln Pro Asp Leu Thr Asp Ser Asp Gly Lys Ser 
                485                 490                 495     


Pro Gln Ala Gln Ala Asp Ser Asp Gly Ser Glu Asn Val Leu Cys Gly 
            500                 505                 510         


Asn Asn Gln Ile Ser Asp Leu Gly Ile Leu Leu Pro Glu Val Cys Met 
        515                 520                 525             


Ala Pro Glu Glu Lys Gly Asp Lys Asp Asp Gln Leu Asn Lys Glu Thr 
    530                 535                 540                 


Glu Asp Tyr Leu Asn Ser Leu Leu Glu Gly Cys Leu Lys Asp Thr Glu 
545                 550                 555                 560 


Asp Ser Leu Ser Tyr Glu Asp Asn Gln Asp Asp Asp Ser Asp Leu Leu 
                565                 570                 575     


Gln Asp Leu Ser Pro Glu Glu Ala Ser Tyr Ser Leu Gln Glu Asn Leu 
            580                 585                 590         


Pro Ser Asp Glu Ser Cys Leu Ser Leu Asp Asp Leu Ala Lys Arg Ile 
        595                 600                 605             


Glu Ile Ala Glu Val Asn Gln Arg 
    610                 615     


<210>  2362
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTF__Homo_sapiens__NP_000605

<400>  2362

Met Ala Phe Thr Glu His Ser Pro Leu Thr Pro His Arg Arg Asp Leu 
1               5                   10                  15      


Cys Ser Arg Ser Ile Trp Leu Ala Arg Lys Ile Arg Ser Asp Leu Thr 
            20                  25                  30          


Ala Leu Thr Glu Ser Tyr Val Lys His Gln Gly Leu Asn Lys Asn Ile 
        35                  40                  45              


Asn Leu Asp Ser Ala Asp Gly Met Pro Val Ala Ser Thr Asp Gln Trp 
    50                  55                  60                  


Ser Glu Leu Thr Glu Ala Glu Arg Leu Gln Glu Asn Leu Gln Ala Tyr 
65                  70                  75                  80  


Arg Thr Phe His Val Leu Leu Ala Arg Leu Leu Glu Asp Gln Gln Val 
                85                  90                  95      


His Phe Thr Pro Thr Glu Gly Asp Phe His Gln Ala Ile His Thr Leu 
            100                 105                 110         


Leu Leu Gln Val Ala Ala Phe Ala Tyr Gln Ile Glu Glu Leu Met Ile 
        115                 120                 125             


Leu Leu Glu Tyr Lys Ile Pro Arg Asn Glu Ala Asp Gly Met Pro Ile 
    130                 135                 140                 


Asn Val Gly Asp Gly Gly Leu Phe Glu Lys Lys Leu Trp Gly Leu Lys 
145                 150                 155                 160 


Val Leu Gln Glu Leu Ser Gln Trp Thr Val Arg Ser Ile His Asp Leu 
                165                 170                 175     


Arg Phe Ile Ser Ser His Gln Thr Gly Ile Pro Ala Arg Gly Ser His 
            180                 185                 190         


Tyr Ile Ala Asn Asn Lys Lys Met 
        195                 200 


<210>  2363
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTFR__Homo_sapiens__NP_001193940

<400>  2363

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  2364
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTLN__Homo_sapiens__NP_001107867

<400>  2364

Met Ala Ala Arg Ser Pro Pro Ser Pro His Pro Ser Pro Pro Ala Arg 
1               5                   10                  15      


Gln Leu Gly Pro Arg Ser Pro Arg Val Gly Arg Gly Ala Glu Val His 
            20                  25                  30          


Ala Met Arg Ser Glu Ala Ser Gly Phe Ala Gly Ala Ala Arg Glu Val 
        35                  40                  45              


Val Ala Asp Glu Ser Asp Lys Ile Trp Val Gly Glu Glu Gly Ser Gly 
    50                  55                  60                  


Gly Arg Arg Gly Pro Gly Gly Ala Ala Pro Ala His Ala Pro Leu Leu 
65                  70                  75                  80  


Ser Ala Pro Met Gly Ser Arg Arg Leu Glu Gly Ile Ser Val Glu Glu 
                85                  90                  95      


Ala Met Val Thr Arg Thr Gln Leu Leu Glu Glu Glu Leu Ser Ser Leu 
            100                 105                 110         


Lys Glu Glu Leu Ala Leu Cys Gln Ala Asp Lys Glu Phe Val Trp Ser 
        115                 120                 125             


Leu Trp Lys Arg Leu Gln Val Thr Asn Pro Asp Leu Thr Gln Val Val 
    130                 135                 140                 


Ser Leu Val Val Glu Arg Glu Lys Gln Lys Ser Glu Ala Lys Asp Arg 
145                 150                 155                 160 


Lys Val Leu Glu Ile Leu Gln Val Lys Asp Ala Lys Ile Gln Glu Phe 
                165                 170                 175     


Glu Gln Arg Glu Ser Val Leu Lys Gln Glu Ile Asn Asp Leu Val Lys 
            180                 185                 190         


Arg Lys Ile Ala Val Asp Glu Glu Asn Ala Phe Leu Arg Lys Glu Phe 
        195                 200                 205             


Ser Asp Leu Glu Lys Lys Phe Lys Asp Lys Ser Gln Glu Ile Lys Asp 
    210                 215                 220                 


Thr Lys Glu Cys Val Gln Asn Lys Glu Glu Gln Asn Arg Leu Val Ile 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Glu Asn Lys Lys Leu Ser Thr Arg Cys Thr Asp 
                245                 250                 255     


Leu Leu Asn Asp Leu Glu Lys Leu Arg Lys Gln Glu Ala His Leu Arg 
            260                 265                 270         


Lys Glu Lys Tyr Ser Thr Asp Ala Lys Ile Lys Thr Phe Glu Asp Asn 
        275                 280                 285             


Leu Ile Glu Ala Arg Lys Glu Val Glu Val Ser Gln Ser Lys Tyr Asn 
    290                 295                 300                 


Ala Leu Ser Leu Gln Leu Ser Asn Lys Gln Thr Glu Leu Ile Gln Lys 
305                 310                 315                 320 


Asp Met Asp Ile Thr Leu Val Arg Lys Glu Leu Gln Glu Leu Gln Asn 
                325                 330                 335     


Leu Tyr Lys Gln Asn Ser Thr His Thr Ala Gln Gln Ala Glu Leu Ile 
            340                 345                 350         


Gln Gln Leu Gln Val Leu Asn Met Asp Thr Gln Lys Val Leu Arg Asn 
        355                 360                 365             


Gln Glu Asp Val His Thr Ala Glu Ser Ile Ser Tyr Gln Lys Val Cys 
    370                 375                 380                 


Phe Tyr Ser Val Ile Lys Met 
385                 390     


<210>  2365
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTN1__Homo_sapiens__NP_001242993

<400>  2365

Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr 
1               5                   10                  15      


Thr Cys Leu Ala Glu Phe Thr Trp Tyr Arg Arg Tyr Gly His Gly Val 
            20                  25                  30          


Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe Glu Glu Gln Pro Ile 
        35                  40                  45              


Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly Lys Val Ser Leu Asn 
    50                  55                  60                  


Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr Lys Trp Arg Met Asn 
65                  70                  75                  80  


Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr Ser Met Val Gly Gly 
                85                  90                  95      


Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys Asp Ala Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val Arg Ser Thr Glu Ala 
        115                 120                 125             


Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro Pro Glu Glu Arg Pro 
    130                 135                 140                 


Glu Val Arg Val Lys Glu Gly Lys Gly Met Val Leu Leu Cys Asp Pro 
145                 150                 155                 160 


Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg Trp Leu Leu Asn Glu 
                165                 170                 175     


Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg Phe Val Ser Gln Thr 
            180                 185                 190         


Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala Ser Asp Lys Gly Asn 
        195                 200                 205             


Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr Lys Ser Val Phe Ser 
    210                 215                 220                 


Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg Thr Thr Lys Pro Tyr 
225                 230                 235                 240 


Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val Tyr Ala Leu Met Gly 
                245                 250                 255     


Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Asp 
            260                 265                 270         


Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro Ser Thr Ala Glu Ile 
        275                 280                 285             


Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn Ile Gln Leu Glu Asp 
    290                 295                 300                 


Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile Arg Gly Lys Asp Lys 
305                 310                 315                 320 


His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro Glu Trp Val Glu His 
                325                 330                 335     


Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp Leu Tyr Trp Pro Cys 
            340                 345                 350         


Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg Trp Leu Lys Asn Gly 
        355                 360                 365             


Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr Asp Val Thr Phe Glu 
    370                 375                 380                 


Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn Thr Tyr Gly Ala Ile 
385                 390                 395                 400 


Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu Ala Pro Thr Phe Glu 
                405                 410                 415     


Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala Lys Gly Gly Arg Val 
            420                 425                 430         


Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys Pro Lys Phe Ser Trp 
        435                 440                 445             


Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser Arg Ile Leu Ile Trp 
    450                 455                 460                 


Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr Arg Asn Asp Gly Gly 
465                 470                 475                 480 


Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly Lys Ala Asn Ser Thr 
                485                 490                 495     


Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile Ile Leu Ala Pro Ile 
            500                 505                 510         


Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr Met Gln Cys Ala Ala 
        515                 520                 525             


Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val Trp Ser Phe Asn Gly 
    530                 535                 540                 


Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His Tyr Gln Arg Asn Phe 
545                 550                 555                 560 


Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg Asn Ala Gln Leu Lys 
                565                 570                 575     


His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr Ile Val Asp Asn Ser 
            580                 585                 590         


Ser Ala Ser Ala Asp Leu Val Val Arg Gly Lys Asn Arg Lys Gly Gly 
        595                 600                 605             


Glu Lys Asn Met Val Asp Ser Phe Leu Pro Val Cys Ala Ser Leu Pro 
    610                 615                 620                 


Pro Thr Trp 
625         


<210>  2366
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTN2__Homo_sapiens__NP_005067

<400>  2366

Met Gly Thr Ala Thr Arg Arg Lys Pro His Leu Leu Leu Val Ala Ala 
1               5                   10                  15      


Val Ala Leu Val Ser Ser Ser Ala Trp Ser Ser Ala Leu Gly Ser Gln 
            20                  25                  30          


Thr Thr Phe Gly Pro Val Phe Glu Asp Gln Pro Leu Ser Val Leu Phe 
        35                  40                  45              


Pro Glu Glu Ser Thr Glu Glu Gln Val Leu Leu Ala Cys Arg Ala Arg 
    50                  55                  60                  


Ala Ser Pro Pro Ala Thr Tyr Arg Trp Lys Met Asn Gly Thr Glu Met 
65                  70                  75                  80  


Lys Leu Glu Pro Gly Ser Arg His Gln Leu Val Gly Gly Asn Leu Val 
                85                  90                  95      


Ile Met Asn Pro Thr Lys Ala Gln Asp Ala Gly Val Tyr Gln Cys Leu 
            100                 105                 110         


Ala Ser Asn Pro Val Gly Thr Val Val Ser Arg Glu Ala Ile Leu Arg 
        115                 120                 125             


Phe Gly Phe Leu Gln Glu Phe Ser Lys Glu Glu Arg Asp Pro Val Lys 
    130                 135                 140                 


Ala His Glu Gly Trp Gly Val Met Leu Pro Cys Asn Pro Pro Ala His 
145                 150                 155                 160 


Tyr Pro Gly Leu Ser Tyr Arg Trp Leu Leu Asn Glu Phe Pro Asn Phe 
                165                 170                 175     


Ile Pro Thr Asp Gly Arg His Phe Val Ser Gln Thr Thr Gly Asn Leu 
            180                 185                 190         


Tyr Ile Ala Arg Thr Asn Ala Ser Asp Leu Gly Asn Tyr Ser Cys Leu 
        195                 200                 205             


Ala Thr Ser His Met Asp Phe Ser Thr Lys Ser Val Phe Ser Lys Phe 
    210                 215                 220                 


Ala Gln Leu Asn Leu Ala Ala Glu Asp Thr Arg Leu Phe Ala Pro Ser 
225                 230                 235                 240 


Ile Lys Ala Arg Phe Pro Ala Glu Thr Tyr Ala Leu Val Gly Gln Gln 
                245                 250                 255     


Val Thr Leu Glu Cys Phe Ala Phe Gly Asn Pro Val Pro Arg Ile Lys 
            260                 265                 270         


Trp Arg Lys Val Asp Gly Ser Leu Ser Pro Gln Trp Thr Thr Ala Glu 
        275                 280                 285             


Pro Thr Leu Gln Ile Pro Ser Val Ser Phe Glu Asp Glu Gly Thr Tyr 
    290                 295                 300                 


Glu Cys Glu Ala Glu Asn Ser Lys Gly Arg Asp Thr Val Gln Gly Arg 
305                 310                 315                 320 


Ile Ile Val Gln Ala Gln Pro Glu Trp Leu Lys Val Ile Ser Asp Thr 
                325                 330                 335     


Glu Ala Asp Ile Gly Ser Asn Leu Arg Trp Gly Cys Ala Ala Ala Gly 
            340                 345                 350         


Lys Pro Arg Pro Thr Val Arg Trp Leu Arg Asn Gly Glu Pro Leu Ala 
        355                 360                 365             


Ser Gln Asn Arg Val Glu Val Leu Ala Gly Asp Leu Arg Phe Ser Lys 
    370                 375                 380                 


Leu Ser Leu Glu Asp Ser Gly Met Tyr Gln Cys Val Ala Glu Asn Lys 
385                 390                 395                 400 


His Gly Thr Ile Tyr Ala Ser Ala Glu Leu Ala Val Gln Ala Leu Ala 
                405                 410                 415     


Pro Asp Phe Arg Leu Asn Pro Val Arg Arg Leu Ile Pro Ala Ala Arg 
            420                 425                 430         


Gly Gly Glu Ile Leu Ile Pro Cys Gln Pro Arg Ala Ala Pro Lys Ala 
        435                 440                 445             


Val Val Leu Trp Ser Lys Gly Thr Glu Ile Leu Val Asn Ser Ser Arg 
    450                 455                 460                 


Val Thr Val Thr Pro Asp Gly Thr Leu Ile Ile Arg Asn Ile Ser Arg 
465                 470                 475                 480 


Ser Asp Glu Gly Lys Tyr Thr Cys Phe Ala Glu Asn Phe Met Gly Lys 
                485                 490                 495     


Ala Asn Ser Thr Gly Ile Leu Ser Val Arg Asp Ala Thr Lys Ile Thr 
            500                 505                 510         


Leu Ala Pro Ser Ser Ala Asp Ile Asn Leu Gly Asp Asn Leu Thr Leu 
        515                 520                 525             


Gln Cys His Ala Ser His Asp Pro Thr Met Asp Leu Thr Phe Thr Trp 
    530                 535                 540                 


Thr Leu Asp Asp Phe Pro Ile Asp Phe Asp Lys Pro Gly Gly His Tyr 
545                 550                 555                 560 


Arg Arg Thr Asn Val Lys Glu Thr Ile Gly Asp Leu Thr Ile Leu Asn 
                565                 570                 575     


Ala Gln Leu Arg His Gly Gly Lys Tyr Thr Cys Met Ala Gln Thr Val 
            580                 585                 590         


Val Asp Ser Ala Ser Lys Glu Ala Thr Val Leu Val Arg Gly Pro Pro 
        595                 600                 605             


Gly Pro Pro Gly Gly Val Val Val Arg Asp Ile Gly Asp Thr Thr Ile 
    610                 615                 620                 


Gln Leu Ser Trp Ser Arg Gly Phe Asp Asn His Ser Pro Ile Ala Lys 
625                 630                 635                 640 


Tyr Thr Leu Gln Ala Arg Thr Pro Pro Ala Gly Lys Trp Lys Gln Val 
                645                 650                 655     


Arg Thr Asn Pro Ala Asn Ile Glu Gly Asn Ala Glu Thr Ala Gln Val 
            660                 665                 670         


Leu Gly Leu Thr Pro Trp Met Asp Tyr Glu Phe Arg Val Ile Ala Ser 
        675                 680                 685             


Asn Ile Leu Gly Thr Gly Glu Pro Ser Gly Pro Ser Ser Lys Ile Arg 
    690                 695                 700                 


Thr Arg Glu Ala Ala Pro Ser Val Ala Pro Ser Gly Leu Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Glu Leu Ile Val Asn Trp Thr Pro Met Ser Arg 
                725                 730                 735     


Glu Tyr Gln Asn Gly Asp Gly Phe Gly Tyr Leu Leu Ser Phe Arg Arg 
            740                 745                 750         


Gln Gly Ser Thr His Trp Gln Thr Ala Arg Val Pro Gly Ala Asp Ala 
        755                 760                 765             


Gln Tyr Phe Val Tyr Ser Asn Glu Ser Val Arg Pro Tyr Thr Pro Phe 
    770                 775                 780                 


Glu Val Lys Ile Arg Ser Tyr Asn Arg Arg Gly Asp Gly Pro Glu Ser 
785                 790                 795                 800 


Leu Thr Ala Leu Val Tyr Ser Ala Glu Glu Glu Pro Arg Val Ala Pro 
                805                 810                 815     


Thr Lys Val Trp Ala Lys Gly Val Ser Ser Ser Glu Met Asn Val Thr 
            820                 825                 830         


Trp Glu Pro Val Gln Gln Asp Met Asn Gly Ile Leu Leu Gly Tyr Glu 
        835                 840                 845             


Ile Arg Tyr Trp Lys Ala Gly Asp Lys Glu Ala Ala Ala Asp Arg Val 
    850                 855                 860                 


Arg Thr Ala Gly Leu Asp Thr Ser Ala Arg Val Ser Gly Leu His Pro 
865                 870                 875                 880 


Asn Thr Lys Tyr His Val Thr Val Arg Ala Tyr Asn Arg Ala Gly Thr 
                885                 890                 895     


Gly Pro Ala Ser Pro Ser Ala Asn Ala Thr Thr Met Lys Pro Pro Pro 
            900                 905                 910         


Arg Arg Pro Pro Gly Asn Ile Ser Trp Thr Phe Ser Ser Ser Ser Leu 
        915                 920                 925             


Ser Ile Lys Trp Asp Pro Val Val Pro Phe Arg Asn Glu Ser Ala Val 
    930                 935                 940                 


Thr Gly Tyr Lys Met Leu Tyr Gln Asn Asp Leu His Leu Thr Pro Thr 
945                 950                 955                 960 


Leu His Leu Thr Gly Lys Asn Trp Ile Glu Ile Pro Val Pro Glu Asp 
                965                 970                 975     


Ile Gly His Ala Leu Val Gln Ile Arg Thr Thr Gly Pro Gly Gly Asp 
            980                 985                 990         


Gly Ile Pro Ala Glu Val His Ile  Val Arg Asn Gly Gly  Thr Ser Met 
        995                 1000                 1005             


Met Val  Glu Asn Met Ala Val  Arg Pro Ala Pro His  Pro Gly Thr 
    1010                 1015                 1020             


Val Ile  Ser His Ser Val Ala  Met Leu Ile Leu Ile  Gly Ser Leu 
    1025                 1030                 1035             


Glu Leu  
    1040 


<210>  2367
<211>  1028
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTN3__Homo_sapiens__NP_065923

<400>  2367

Met Met Phe Pro Trp Lys Gln Leu Ile Leu Leu Ser Phe Ile Gly Cys 
1               5                   10                  15      


Leu Gly Gly Glu Leu Leu Leu Gln Gly Pro Val Phe Ile Lys Glu Pro 
            20                  25                  30          


Ser Asn Ser Ile Phe Pro Val Gly Ser Glu Asp Lys Lys Ile Thr Leu 
        35                  40                  45              


His Cys Glu Ala Arg Gly Asn Pro Ser Pro His Tyr Arg Trp Gln Leu 
    50                  55                  60                  


Asn Gly Ser Asp Ile Asp Met Ser Met Glu His Arg Tyr Lys Leu Asn 
65                  70                  75                  80  


Gly Gly Asn Leu Val Val Ile Asn Pro Asn Arg Asn Trp Asp Thr Gly 
                85                  90                  95      


Thr Tyr Gln Cys Phe Ala Thr Asn Ser Leu Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln 
                165                 170                 175     


Glu Thr Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly 
            180                 185                 190         


Asn Tyr Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu 
        195                 200                 205             


Gly Ser Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu 
    210                 215                 220                 


Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala 
225                 230                 235                 240 


Lys Gly Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile 
                245                 250                 255     


Pro Gln Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys 
            260                 265                 270         


Ile Lys Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln 
        275                 280                 285             


Gln Glu Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly 
    290                 295                 300                 


Lys Asn Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp 
305                 310                 315                 320 


Val Gln Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr 
                325                 330                 335     


Trp Glu Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu 
            340                 345                 350         


Lys Asn Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn 
        355                 360                 365             


Gly Ala Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe 
    370                 375                 380                 


Gln Cys Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu 
385                 390                 395                 400 


Leu Lys Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys 
                405                 410                 415     


Lys Leu Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys 
            420                 425                 430         


Pro Arg Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val 
        435                 440                 445             


Ser Val Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu 
    450                 455                 460                 


Lys Ile Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met 
465                 470                 475                 480 


Ala Glu Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val 
                485                 490                 495     


Thr Glu Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser 
            500                 505                 510         


Val Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu 
        515                 520                 525             


Leu Asp Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe 
    530                 535                 540                 


Lys Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly 
545                 550                 555                 560 


Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val 
                565                 570                 575     


Cys Met Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu 
            580                 585                 590         


Ile Val Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu 
        595                 600                 605             


Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn 
    610                 615                 620                 


His Ser Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser 
625                 630                 635                 640 


Val Gly Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys 
                645                 650                 655     


Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu 
            660                 665                 670         


Phe Arg Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu 
        675                 680                 685             


Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro 
    690                 695                 700                 


Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr 
705                 710                 715                 720 


Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr 
                725                 730                 735     


Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val 
            740                 745                 750         


Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile 
        755                 760                 765             


Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys 
    770                 775                 780                 


Gly Glu Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu 
785                 790                 795                 800 


Glu Pro Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser 
                805                 810                 815     


Ser Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn 
            820                 825                 830         


Gly His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys 
        835                 840                 845             


Glu Glu Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala 
    850                 855                 860                 


Arg Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg 
865                 870                 875                 880 


Ala Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val 
                885                 890                 895     


Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp 
            900                 905                 910         


Asn Ala Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala 
        915                 920                 925             


Met Glu Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr 
    930                 935                 940                 


Ser Ser Gln Asn Asn Val Gln Val Leu Asn Thr Asn Lys Thr Ser Ala 
945                 950                 955                 960 


Glu Leu Val Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala 
                965                 970                 975     


Thr Thr Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro 
            980                 985                 990         


Arg Ile Thr Ser Met Asp Ala Arg  Gly Ser Thr Ser Ala  Ile Ser Asn 
        995                 1000                 1005             


Val His  Pro Met Ser Ser Tyr  Met Pro Ile Val Leu  Phe Leu Ile 
    1010                 1015                 1020             


Val Tyr  Val Leu Trp 
    1025             


<210>  2368
<211>  1026
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTN4__Homo_sapiens__NP_001193884

<400>  2368

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu 
    210                 215                 220                 


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys Gly 
225                 230                 235                 240 


Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr 
                245                 250                 255     


Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg 
            260                 265                 270         


Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu 
        275                 280                 285             


Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile Gln 
305                 310                 315                 320 


Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu 
                325                 330                 335     


Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn 
            340                 345                 350         


Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr 
        355                 360                 365             


Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser 
385                 390                 395                 400 


Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val 
                405                 410                 415     


Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys 
            420                 425                 430         


Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu 
        435                 440                 445             


Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile 
    450                 455                 460                 


Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr 
465                 470                 475                 480 


Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys Asp 
                485                 490                 495     


Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp 
        515                 520                 525             


Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp Arg 
    530                 535                 540                 


Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys 
                565                 570                 575     


Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu Ile 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile 
        595                 600                 605             


Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val 
625                 630                 635                 640 


Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr 
                645                 650                 655     


Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro 
        675                 680                 685             


Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala 
    690                 695                 700                 


Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp 
705                 710                 715                 720 


Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val 
                725                 730                 735     


Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val Leu 
            740                 745                 750         


Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val His 
        755                 760                 765             


Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly 
    770                 775                 780                 


Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu Glu 
785                 790                 795                 800 


Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
                805                 810                 815     


Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg 
            820                 825                 830         


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu 
        835                 840                 845             


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    850                 855                 860                 


Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr 
865                 870                 875                 880 


Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr Thr 
                885                 890                 895     


Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser 
            900                 905                 910         


Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp 
        915                 920                 925             


Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg 
    930                 935                 940                 


Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu 
945                 950                 955                 960 


Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser 
                965                 970                 975     


Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile 
            980                 985                 990         


Ser Asn Ala Tyr Ala Arg Gly Ser  Gly Ala Ser Thr Ser  Asn Ala Cys 
        995                 1000                 1005             


Thr Leu  Ser Ala Ile Ser Thr  Ile Met Ile Ser Leu  Thr Ala Arg 
    1010                 1015                 1020             


Ser Ser  Leu 
    1025     


<210>  2369
<211>  1100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTN5__Homo_sapiens__NP_001230199

<400>  2369

Met Ala Ser Ser Trp Lys Leu Met Leu Phe Leu Ser Val Thr Met Cys 
1               5                   10                  15      


Leu Ser Glu Tyr Ser Lys Ser Leu Pro Gly Leu Ser Thr Ser Tyr Ala 
            20                  25                  30          


Ala Leu Leu Arg Ile Lys Lys Ser Ser Ser Ser Ser Leu Phe Gly Ser 
        35                  40                  45              


Lys Thr Arg Pro Arg Tyr Ser Ser Pro Ser Leu Gly Thr Leu Ser Ala 
    50                  55                  60                  


Ser Ser Pro Ser Trp Leu Gly Ala Ala Gln Asn Tyr Tyr Ser Pro Ile 
65                  70                  75                  80  


Asn Leu Tyr His Ser Ser Asp Ala Phe Lys Gln Asp Glu Ser Val Asp 
                85                  90                  95      


Tyr Gly Pro Val Phe Val Gln Glu Pro Asp Asp Ile Ile Phe Pro Thr 
            100                 105                 110         


Asp Ser Asp Glu Lys Lys Val Ala Leu Asn Cys Glu Val Arg Gly Asn 
        115                 120                 125             


Pro Val Pro Ser Tyr Arg Trp Leu Arg Asn Gly Thr Glu Ile Asp Leu 
    130                 135                 140                 


Glu Ser Asp Tyr Arg Tyr Ser Leu Ile Asp Gly Thr Phe Ile Ile Ser 
145                 150                 155                 160 


Asn Pro Ser Glu Ala Lys Asp Ser Gly His Tyr Gln Cys Leu Ala Thr 
                165                 170                 175     


Asn Thr Val Gly Ser Ile Leu Ser Arg Glu Ala Thr Leu Gln Phe Ala 
            180                 185                 190         


Tyr Leu Gly Asn Phe Ser Gly Arg Thr Arg Ser Ala Val Ser Val Arg 
        195                 200                 205             


Glu Gly Gln Gly Val Val Leu Met Cys Ser Pro Pro Pro His Ser Pro 
    210                 215                 220                 


Glu Ile Ile Tyr Ser Trp Val Phe Asn Glu Phe Pro Ser Phe Val Ala 
225                 230                 235                 240 


Glu Asp Ser Arg Arg Phe Ile Ser Gln Glu Thr Gly Asn Leu Tyr Ile 
                245                 250                 255     


Ser Lys Val Gln Thr Ser Asp Val Gly Ser Tyr Ile Cys Leu Val Lys 
            260                 265                 270         


Asn Thr Val Thr Asn Ala Arg Val Leu Ser Pro Pro Thr Pro Leu Thr 
        275                 280                 285             


Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val 
    290                 295                 300                 


His Phe Pro Phe Thr Val Thr Ala Ala Lys Gly Thr Thr Val Lys Met 
305                 310                 315                 320 


Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr Ile Thr Trp Met Lys 
                325                 330                 335     


Val Asn Gly Tyr Ile Pro Ser Lys Ala Arg Leu Arg Lys Ser Gln Ala 
            340                 345                 350         


Val Leu Glu Ile Pro Asn Val Gln Leu Asp Asp Ala Gly Ile Tyr Glu 
        355                 360                 365             


Cys Arg Ala Glu Asn Ser Arg Gly Lys Asn Ser Phe Arg Gly Gln Leu 
    370                 375                 380                 


Gln Val Tyr Thr Tyr Pro His Trp Val Glu Lys Leu Asn Asp Thr Gln 
385                 390                 395                 400 


Leu Asp Ser Gly Ser Pro Leu Arg Trp Glu Cys Lys Ala Thr Gly Lys 
                405                 410                 415     


Pro Arg Pro Thr Tyr Arg Trp Leu Lys Asn Gly Val Pro Leu Ser Pro 
            420                 425                 430         


Gln Ser Arg Val Glu Met Val Asn Gly Val Leu Met Ile His Asn Val 
        435                 440                 445             


Asn Gln Ser Asp Ala Gly Met Tyr Gln Cys Leu Ala Glu Asn Lys Tyr 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Ser Ala Glu Leu Lys Ile Leu Ala Ser Ala Pro 
465                 470                 475                 480 


Thr Phe Ala Leu Asn Gln Leu Lys Lys Thr Ile Ile Val Thr Lys Asp 
                485                 490                 495     


Gln Glu Val Val Ile Glu Cys Lys Pro Gln Gly Ser Pro Lys Pro Thr 
            500                 505                 510         


Ile Ser Trp Lys Lys Gly Asp Arg Ala Val Arg Glu Asn Lys Arg Ile 
        515                 520                 525             


Ala Ile Leu Pro Asp Gly Ser Leu Arg Ile Leu Asn Ala Ser Lys Ser 
    530                 535                 540                 


Asp Glu Gly Lys Tyr Val Cys Arg Gly Glu Asn Val Phe Gly Ser Ala 
545                 550                 555                 560 


Glu Ile Ile Ala Ser Leu Ser Val Lys Glu Pro Thr Arg Ile Glu Leu 
                565                 570                 575     


Thr Pro Lys Arg Thr Glu Leu Thr Val Gly Glu Ser Ile Val Leu Asn 
            580                 585                 590         


Cys Lys Ala Ile His Asp Ala Ser Leu Asp Val Thr Phe Tyr Trp Thr 
        595                 600                 605             


Leu Lys Gly Gln Pro Ile Asp Phe Glu Glu Glu Gly Gly His Phe Glu 
    610                 615                 620                 


Ser Ile Arg Ala Gln Ala Ser Ser Ala Asp Leu Met Ile Arg Asn Ile 
625                 630                 635                 640 


Leu Leu Met His Ala Gly Arg Tyr Gly Cys Arg Val Gln Thr Thr Ala 
                645                 650                 655     


Asp Ser Val Ser Asp Glu Ala Glu Leu Leu Val Arg Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Ile Val Ile Val Glu Glu Ile Thr Glu Ser Thr Ala Thr 
        675                 680                 685             


Leu Ser Trp Ser Pro Ala Ala Asp Asn His Ser Pro Ile Ser Ser Tyr 
    690                 695                 700                 


Asn Leu Gln Ala Arg Ser Pro Phe Ser Leu Gly Trp Gln Thr Val Lys 
705                 710                 715                 720 


Thr Val Pro Glu Ile Ile Thr Gly Asp Met Glu Ser Ala Met Ala Val 
                725                 730                 735     


Asp Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Thr Asn 
            740                 745                 750         


Pro Ile Gly Thr Gly Asp Pro Ser Thr Pro Ser Arg Met Ile Arg Thr 
        755                 760                 765             


Asn Glu Ala Val Pro Lys Thr Ala Pro Thr Asn Val Ser Gly Arg Ser 
    770                 775                 780                 


Gly Arg Arg His Glu Leu Val Ile Ala Trp Glu Pro Val Ser Glu Glu 
785                 790                 795                 800 


Phe Gln Asn Gly Glu Gly Phe Gly Tyr Ile Val Ala Phe Arg Pro Asn 
                805                 810                 815     


Gly Thr Arg Gly Trp Lys Glu Lys Met Val Thr Ser Ser Glu Ala Ser 
            820                 825                 830         


Lys Phe Ile Tyr Arg Asp Glu Ser Val Pro Pro Leu Thr Pro Phe Glu 
        835                 840                 845             


Val Lys Val Gly Val Tyr Asn Asn Lys Gly Asp Gly Pro Phe Ser Gln 
    850                 855                 860                 


Ile Val Val Ile Cys Ser Ala Glu Gly Glu Pro Ser Ala Ala Pro Thr 
865                 870                 875                 880 


Asp Val Lys Ala Thr Ser Val Ser Val Ser Glu Ile Leu Val Ala Trp 
                885                 890                 895     


Lys His Ile Lys Glu Ser Leu Gly Arg Pro Gln Gly Phe Glu Val Gly 
            900                 905                 910         


Tyr Trp Lys Asp Met Glu Gln Glu Asp Thr Ala Glu Thr Val Lys Thr 
        915                 920                 925             


Arg Gly Asn Glu Ser Phe Val Ile Leu Thr Gly Leu Glu Gly Asn Thr 
    930                 935                 940                 


Leu Tyr His Phe Thr Val Arg Ala Tyr Asn Gly Ala Gly Tyr Gly Pro 
945                 950                 955                 960 


Pro Ser Ser Glu Val Ser Ala Thr Thr Lys Lys Ser Pro Pro Ser Gln 
                965                 970                 975     


Ala Pro Ser Asn Leu Arg Trp Glu Gln Gln Gly Ser Gln Val Ser Leu 
            980                 985                 990         


Gly Trp Glu Pro Val Ile Pro Leu  Ala Asn Glu Ser Glu  Val Val Gly 
        995                 1000                 1005             


Tyr Lys  Val Phe Tyr Arg Gln  Glu Gly His Ser Asn  Ser Gln Val 
    1010                 1015                 1020             


Ile Glu  Thr Gln Lys Leu Gln  Ala Val Val Pro Leu  Pro Asp Ala 
    1025                 1030                 1035             


Gly Val  Tyr Ile Ile Glu Val  Arg Ala Tyr Ser Glu  Gly Gly Asp 
    1040                 1045                 1050             


Gly Thr  Ala Ser Ser Gln Ile  Arg Val Pro Ser Tyr  Ser Gly Gly 
    1055                 1060                 1065             


Lys Ile  Thr Ser Ala Gln Ser  Thr Leu His Ser Leu  Ser Thr Ser 
    1070                 1075                 1080             


Ser Ser  Ser Val Thr Leu Leu  Leu Ala Leu Met Ile  Pro Ser Thr 
    1085                 1090                 1095             


Ser Trp  
    1100 


<210>  2370
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTN6__Homo_sapiens__NP_001276010

<400>  2370

Met Ser Tyr His Tyr Arg Leu Asp Gly Gly Ser Leu Ala Ile Asn Ser 
1               5                   10                  15      


Pro His Thr Asp Gln Asp Ile Gly Met Tyr Gln Cys Leu Ala Thr Asn 
            20                  25                  30          


Leu Leu Gly Thr Ile Leu Ser Arg Lys Ala Lys Leu Gln Phe Ala Tyr 
        35                  40                  45              


Ile Glu Asp Phe Glu Thr Lys Thr Arg Ser Thr Val Ser Val Arg Glu 
    50                  55                  60                  


Gly Gln Gly Val Val Leu Leu Cys Gly Pro Pro Pro His Phe Gly Asp 
65                  70                  75                  80  


Leu Ser Tyr Ala Trp Thr Phe Asn Asp Asn Pro Leu Tyr Val Gln Glu 
                85                  90                  95      


Asp Asn Arg Arg Phe Val Ser Gln Glu Thr Gly Asn Leu Tyr Ile Ala 
            100                 105                 110         


Lys Val Glu Pro Ser Asp Val Gly Asn Tyr Thr Cys Phe Ile Thr Asn 
        115                 120                 125             


Lys Glu Ala Gln Arg Ser Val Gln Gly Pro Pro Thr Pro Leu Val Gln 
    130                 135                 140                 


Arg Thr Asp Gly Val Met Gly Glu Tyr Glu Pro Lys Ile Glu Val Arg 
145                 150                 155                 160 


Phe Pro Glu Thr Ile Gln Ala Ala Lys Asp Ser Ser Val Lys Leu Glu 
                165                 170                 175     


Cys Phe Ala Leu Gly Asn Pro Val Pro Asp Ile Ser Trp Arg Arg Leu 
            180                 185                 190         


Asp Gly Ser Pro Leu Pro Gly Lys Val Lys Tyr Ser Lys Ser Gln Ala 
        195                 200                 205             


Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu Asp Glu Gly Phe Tyr Glu 
    210                 215                 220                 


Cys Ile Ala Ser Asn Leu Arg Gly Arg Asn Leu Ala Lys Gly Gln Leu 
225                 230                 235                 240 


Ile Phe Tyr Ala Pro Pro Glu Trp Glu Gln Lys Ile Gln Asn Thr His 
                245                 250                 255     


Leu Ser Ile Tyr Asp Asn Leu Leu Trp Glu Cys Lys Ala Ser Gly Lys 
            260                 265                 270         


Pro Asn Pro Trp Tyr Thr Trp Leu Lys Asn Gly Glu Arg Leu Asn Pro 
        275                 280                 285             


Glu Glu Arg Ile Gln Ile Glu Asn Gly Thr Leu Ile Ile Thr Met Leu 
    290                 295                 300                 


Asn Val Ser Asp Ser Gly Val Tyr Gln Cys Ala Ala Glu Asn Lys Tyr 
305                 310                 315                 320 


Gln Ile Ile Tyr Ala Asn Ala Glu Leu Arg Val Leu Ala Ser Ala Pro 
                325                 330                 335     


Asp Phe Ser Lys Ser Pro Val Lys Lys Lys Ser Phe Val Gln Val Gly 
            340                 345                 350         


Gly Asp Ile Val Ile Gly Cys Lys Pro Asn Ala Phe Pro Arg Ala Ala 
        355                 360                 365             


Ile Ser Trp Lys Arg Gly Thr Glu Thr Leu Arg Gln Ser Lys Arg Ile 
    370                 375                 380                 


Phe Leu Leu Glu Asp Gly Ser Leu Lys Ile Tyr Asn Ile Thr Arg Ser 
385                 390                 395                 400 


Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr Asn Gln Phe Gly Thr Ala 
                405                 410                 415     


Lys Asn Thr Gly Ser Leu Ile Val Lys Glu Arg Thr Val Ile Thr Val 
            420                 425                 430         


Pro Pro Ser Lys Met Asp Val Thr Val Gly Glu Ser Ile Val Leu Pro 
        435                 440                 445             


Cys Gln Val Ser His Asp Pro Ser Ile Glu Val Val Phe Val Trp Phe 
    450                 455                 460                 


Phe Asn Gly Asp Val Ile Asp Leu Lys Lys Gly Val Ala His Phe Glu 
465                 470                 475                 480 


Arg Ile Gly Gly Glu Ser Val Gly Asp Leu Met Ile Arg Asn Ile Gln 
                485                 490                 495     


Leu His His Ser Gly Lys Tyr Leu Cys Thr Val Gln Thr Thr Leu Glu 
            500                 505                 510         


Ser Leu Ser Ala Val Ala Asp Ile Ile Val Arg Gly Pro Pro Gly Pro 
        515                 520                 525             


Pro Glu Asp Val Gln Val Glu Asp Ile Ser Ser Thr Thr Ser Gln Leu 
    530                 535                 540                 


Ser Trp Arg Ala Gly Pro Asp Asn Asn Ser Pro Ile Gln Ile Phe Thr 
545                 550                 555                 560 


Ile Gln Thr Arg Thr Pro Phe Ser Val Gly Trp Gln Ala Val Ala Thr 
                565                 570                 575     


Val Pro Glu Ile Leu Asn Gly Lys Thr Tyr Asn Ala Thr Val Val Gly 
            580                 585                 590         


Leu Ser Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala Gly Asn Ser 
        595                 600                 605             


Ile Gly Ile Gly Glu Pro Ser Glu Pro Ser Glu Leu Leu Arg Thr Lys 
    610                 615                 620                 


Ala Ser Val Pro Val Val Ala Pro Val Asn Ile His Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Arg Ser Glu Leu Val Ile Thr Trp Glu Ser Ile Pro Glu Glu Leu 
                645                 650                 655     


Gln Asn Gly Glu Gly Phe Gly Tyr Ile Ile Met Phe Arg Pro Val Gly 
            660                 665                 670         


Ser Thr Thr Trp Ser Lys Glu Lys Val Ser Ser Val Glu Ser Ser Arg 
        675                 680                 685             


Phe Val Tyr Arg Asn Glu Ser Ile Ile Pro Leu Ser Pro Phe Glu Val 
    690                 695                 700                 


Lys Val Gly Val Tyr Asn Asn Glu Gly Glu Gly Ser Leu Ser Thr Val 
705                 710                 715                 720 


Thr Ile Val Tyr Ser Gly Glu Asp Glu Pro Gln Leu Ala Pro Arg Gly 
                725                 730                 735     


Thr Ser Leu Gln Ser Phe Ser Ala Ser Glu Met Glu Val Ser Trp Asn 
            740                 745                 750         


Ala Ile Ala Trp Asn Arg Asn Thr Gly Arg Val Leu Gly Tyr Glu Val 
        755                 760                 765             


Leu Tyr Trp Thr Asp Asp Ser Lys Glu Ser Met Ile Gly Lys Ile Arg 
    770                 775                 780                 


Val Ser Gly Asn Val Thr Thr Lys Asn Ile Thr Gly Leu Lys Ala Asn 
785                 790                 795                 800 


Thr Ile Tyr Phe Ala Ser Val Arg Ala Tyr Asn Thr Ala Gly Thr Gly 
                805                 810                 815     


Pro Ser Ser Pro Pro Val Asn Val Thr Thr Lys Lys Ser Pro Pro Ser 
            820                 825                 830         


Gln Pro Pro Ala Asn Ile Ala Trp Lys Leu Thr Asn Ser Lys Leu Cys 
        835                 840                 845             


Leu Asn Trp Glu His Val Lys Thr Met Glu Asn Glu Ser Glu Val Leu 
    850                 855                 860                 


Gly Tyr Lys Ile Leu Tyr Arg Gln Asn Arg Gln Ser Lys Thr His Ile 
865                 870                 875                 880 


Leu Glu Thr Asn Asn Thr Ser Ala Glu Leu Leu Val Pro Phe Glu Glu 
                885                 890                 895     


Asp Tyr Leu Ile Glu Ile Arg Thr Val Ser Asp Gly Gly Asp Gly Ser 
            900                 905                 910         


Ser Ser Glu Glu Ile Arg Ile Pro Lys Met Ser Ser Leu Ser Ser Arg 
        915                 920                 925             


Gly Ile Gln Phe Leu Glu Pro Ser Thr His Phe Leu Ser Ile Val Ile 
    930                 935                 940                 


Val Ile Phe His Cys Phe Ala Ile Gln Pro Leu Ile 
945                 950                 955     


<210>  2371
<211>  1384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTNAP1__Homo_sapiens__NP_003623

<400>  2371

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
    370                 375                 380                 


Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu Phe 
385                 390                 395                 400 


Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Thr Leu Ser Glu 
                405                 410                 415     


Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
            420                 425                 430         


Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
        435                 440                 445             


Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
    450                 455                 460                 


Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly Thr 
465                 470                 475                 480 


Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                485                 490                 495     


His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
            500                 505                 510         


Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Gly Arg Arg Leu Gly 
        515                 520                 525             


Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg Cys 
    530                 535                 540                 


Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
545                 550                 555                 560 


Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Glu Thr Cys 
                565                 570                 575     


His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
            580                 585                 590         


Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp Gly Ser Gly Pro Leu 
        595                 600                 605             


Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Thr 
    610                 615                 620                 


Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser Ser 
625                 630                 635                 640 


Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                645                 650                 655     


Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
            660                 665                 670         


Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly Gly 
        675                 680                 685             


Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
    690                 695                 700                 


Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
705                 710                 715                 720 


Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                725                 730                 735     


Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His Leu 
            740                 745                 750         


Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Thr Ser Glu 
        755                 760                 765             


Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
    770                 775                 780                 


Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro Pro 
785                 790                 795                 800 


Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr Ser 
                805                 810                 815     


Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
            820                 825                 830         


Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp Val 
        835                 840                 845             


Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Thr Val His 
    850                 855                 860                 


Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
865                 870                 875                 880 


Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                885                 890                 895     


Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Met Glu Tyr Asp 
            900                 905                 910         


Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
        915                 920                 925             


Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu Glu 
    930                 935                 940                 


Gly Arg Ala Asn Ala Ser Glu Gly Thr Ser Pro Asn Cys Thr Gly His 
945                 950                 955                 960 


Cys Ala His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu 
                965                 970                 975     


Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly 
            980                 985                 990         


Pro Tyr Cys Asn His Asp Ile Gly  Gly Phe Phe Glu Pro  Gly Thr Trp 
        995                 1000                 1005             


Met Arg  Tyr Asn Leu Gln Ser  Ala Leu Arg Ser Ala  Ala Arg Glu 
    1010                 1015                 1020             


Phe Ser  His Met Leu Ser Arg  Pro Val Pro Gly Tyr  Glu Pro Gly 
    1025                 1030                 1035             


Tyr Ile  Pro Gly Tyr Asp Thr  Pro Gly Tyr Val Pro  Gly Tyr His 
    1040                 1045                 1050             


Gly Pro  Gly Tyr Arg Leu Pro  Asp Tyr Pro Arg Pro  Gly Arg Pro 
    1055                 1060                 1065             


Val Pro  Gly Tyr Arg Gly Pro  Val Tyr Asn Val Thr  Gly Glu Glu 
    1070                 1075                 1080             


Val Ser  Phe Ser Phe Ser Thr  Ser Ser Ala Pro Ala  Val Leu Leu 
    1085                 1090                 1095             


Tyr Val  Ser Ser Phe Val Arg  Asp Tyr Met Ala Val  Leu Ile Lys 
    1100                 1105                 1110             


Asp Asp  Gly Thr Leu Gln Leu  Arg Tyr Gln Leu Gly  Thr Ser Pro 
    1115                 1120                 1125             


Tyr Val  Tyr Gln Leu Thr Thr  Arg Pro Val Thr Asp  Gly Gln Pro 
    1130                 1135                 1140             


His Ser  Ile Asn Ile Thr Arg  Val Tyr Arg Asn Leu  Phe Ile Gln 
    1145                 1150                 1155             


Val Asp  Tyr Phe Pro Leu Thr  Glu Gln Lys Phe Ser  Leu Leu Val 
    1160                 1165                 1170             


Asp Ser  Gln Leu Asp Ser Pro  Lys Ala Leu Tyr Leu  Gly Arg Val 
    1175                 1180                 1185             


Met Glu  Thr Gly Val Ile Asp  Pro Glu Ile Gln Arg  Tyr Asn Thr 
    1190                 1195                 1200             


Pro Gly  Phe Ser Gly Cys Leu  Ser Gly Val Arg Phe  Asn Asn Val 
    1205                 1210                 1215             


Ala Pro  Leu Lys Thr His Phe  Arg Thr Pro Arg Pro  Met Thr Ala 
    1220                 1225                 1230             


Glu Leu  Ala Glu Ala Leu Arg  Val Gln Gly Glu Leu  Ser Glu Ser 
    1235                 1240                 1245             


Asn Cys  Gly Ala Met Pro Arg  Leu Val Ser Glu Val  Pro Pro Glu 
    1250                 1255                 1260             


Leu Asp  Pro Trp Tyr Leu Pro  Pro Asp Phe Pro Tyr  Tyr His Asp 
    1265                 1270                 1275             


Glu Gly  Trp Val Ala Ile Leu  Leu Gly Phe Leu Val  Ala Phe Leu 
    1280                 1285                 1290             


Leu Leu  Gly Leu Val Gly Met  Leu Val Leu Phe Tyr  Leu Gln Asn 
    1295                 1300                 1305             


His Arg  Tyr Lys Gly Ser Tyr  His Thr Asn Glu Pro  Lys Ala Ala 
    1310                 1315                 1320             


His Glu  Tyr His Pro Gly Ser  Lys Pro Pro Leu Pro  Thr Ser Gly 
    1325                 1330                 1335             


Pro Ala  Gln Val Pro Thr Pro  Thr Ala Ala Pro Asn  Gln Ala Pro 
    1340                 1345                 1350             


Ala Ser  Ala Pro Ala Pro Ala  Pro Thr Pro Ala Pro  Ala Pro Gly 
    1355                 1360                 1365             


Pro Arg  Asp Gln Asn Leu Pro  Gln Ile Leu Glu Glu  Ser Arg Ser 
    1370                 1375                 1380             


Glu 
    


<210>  2372
<211>  1331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTNAP2__Homo_sapiens__NP_054860

<400>  2372

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu 
    370                 375                 380                 


Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
                405                 410                 415     


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            420                 425                 430         


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        435                 440                 445             


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    450                 455                 460                 


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
465                 470                 475                 480 


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                485                 490                 495     


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            500                 505                 510         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        515                 520                 525             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    530                 535                 540                 


Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro 
545                 550                 555                 560 


Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe 
                565                 570                 575     


Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Asn 
            580                 585                 590         


Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln Thr 
        595                 600                 605             


Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly Pro 
    610                 615                 620                 


Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile Val 
625                 630                 635                 640 


Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro Glu 
                645                 650                 655     


Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln Ile 
            660                 665                 670         


Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser Tyr 
        675                 680                 685             


Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro Tyr 
    690                 695                 700                 


Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly Gly 
705                 710                 715                 720 


Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn Cys 
                725                 730                 735     


Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln Trp 
            740                 745                 750         


Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val Ser 
        755                 760                 765             


Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu 
    770                 775                 780                 


Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala 
785                 790                 795                 800 


Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe Gln 
                805                 810                 815     


Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro 
            820                 825                 830         


Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys Leu 
        835                 840                 845             


Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly Asn 
    850                 855                 860                 


Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp Asp 
865                 870                 875                 880 


Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser Leu 
                885                 890                 895     


Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly 
            900                 905                 910         


His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly 
        915                 920                 925             


Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn Gly 
    930                 935                 940                 


Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe Ile 
945                 950                 955                 960 


Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn 
                965                 970                 975     


Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser 
            980                 985                 990         


Asn Thr Ala Tyr Asp Gly Thr Phe  Cys Asn Lys Asp Val  Gly Ala Phe 
        995                 1000                 1005             


Phe Glu  Glu Gly Met Trp Leu  Arg Tyr Asn Phe Gln  Ala Pro Ala 
    1010                 1015                 1020             


Thr Asn  Ala Arg Asp Ser Ser  Ser Arg Val Asp Asn  Ala Pro Asp 
    1025                 1030                 1035             


Gln Gln  Asn Ser His Pro Asp  Leu Ala Gln Glu Glu  Ile Arg Phe 
    1040                 1045                 1050             


Ser Phe  Ser Thr Thr Lys Ala  Pro Cys Ile Leu Leu  Tyr Ile Ser 
    1055                 1060                 1065             


Ser Phe  Thr Thr Asp Phe Leu  Ala Val Leu Val Lys  Pro Thr Gly 
    1070                 1075                 1080             


Ser Leu  Gln Ile Arg Tyr Asn  Leu Gly Gly Thr Arg  Glu Pro Tyr 
    1085                 1090                 1095             


Asn Ile  Asp Val Asp His Arg  Asn Met Ala Asn Gly  Gln Pro His 
    1100                 1105                 1110             


Ser Val  Asn Ile Thr Arg His  Glu Lys Thr Ile Phe  Leu Lys Leu 
    1115                 1120                 1125             


Asp His  Tyr Pro Ser Val Ser  Tyr His Leu Pro Ser  Ser Ser Asp 
    1130                 1135                 1140             


Thr Leu  Phe Asn Ser Pro Lys  Ser Leu Phe Leu Gly  Lys Val Ile 
    1145                 1150                 1155             


Glu Thr  Gly Lys Ile Asp Gln  Glu Ile His Lys Tyr  Asn Thr Pro 
    1160                 1165                 1170             


Gly Phe  Thr Gly Cys Leu Ser  Arg Val Gln Phe Asn  Gln Ile Ala 
    1175                 1180                 1185             


Pro Leu  Lys Ala Ala Leu Arg  Gln Thr Asn Ala Ser  Ala His Val 
    1190                 1195                 1200             


His Ile  Gln Gly Glu Leu Val  Glu Ser Asn Cys Gly  Ala Ser Pro 
    1205                 1210                 1215             


Leu Thr  Leu Ser Pro Met Ser  Ser Ala Thr Asp Pro  Trp His Leu 
    1220                 1225                 1230             


Asp His  Leu Asp Ser Ala Ser  Ala Asp Phe Pro Tyr  Asn Pro Gly 
    1235                 1240                 1245             


Gln Gly  Gln Ala Ile Arg Asn  Gly Val Asn Arg Asn  Ser Ala Ile 
    1250                 1255                 1260             


Ile Gly  Gly Val Ile Ala Val  Val Ile Phe Thr Ile  Leu Cys Thr 
    1265                 1270                 1275             


Leu Val  Phe Leu Ile Arg Tyr  Met Phe Arg His Lys  Gly Thr Tyr 
    1280                 1285                 1290             


His Thr  Asn Glu Ala Lys Gly  Ala Glu Ser Ala Glu  Ser Ala Asp 
    1295                 1300                 1305             


Ala Ala  Ile Met Asn Asn Asp  Pro Asn Phe Thr Glu  Thr Ile Asp 
    1310                 1315                 1320             


Glu Ser  Lys Lys Glu Trp Leu  Ile 
    1325                 1330     


<210>  2373
<211>  1288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTNAP3__Homo_sapiens__NP_387504

<400>  2373

Met Ala Ser Val Ala Trp Ala Val Leu Lys Val Leu Leu Leu Leu Pro 
1               5                   10                  15      


Thr Gln Thr Trp Ser Pro Val Gly Ala Gly Asn Pro Pro Asp Cys Asp 
            20                  25                  30          


Ala Pro Leu Ala Ser Ala Leu Pro Arg Ser Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ser Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Thr Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Gly Gly Arg Asn Trp Lys Gln Tyr Arg Arg Glu Glu Ser 
        115                 120                 125             


Ile Trp Gly Phe Pro Gly Asn Thr Asn Ala Asp Ser Val Val His Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Pro Phe Glu Ala Arg Phe Leu Arg Phe Leu Pro Leu 
145                 150                 155                 160 


Ala Trp Asn Pro Arg Gly Arg Ile Gly Met Arg Ile Glu Val Tyr Gly 
                165                 170                 175     


Cys Ala Tyr Lys Ser Glu Val Val Tyr Phe Asp Gly Gln Ser Ala Leu 
            180                 185                 190         


Leu Tyr Arg Leu Asp Lys Lys Pro Leu Lys Pro Ile Arg Asp Val Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Ala Met Gln Ser Asn Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Gln His Gly Asn His Ile Thr Leu Glu Leu Ile Lys Gly Lys 
225                 230                 235                 240 


Leu Val Phe Phe Leu Asn Ser Gly Asn Ala Lys Leu Pro Ser Thr Ile 
                245                 250                 255     


Ala Pro Val Thr Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Glu Leu Leu Asp Thr Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Lys His Thr His His Phe Gln Ala Lys Gly Asp Ser Ser Tyr Leu 
    290                 295                 300                 


Asp Leu Asn Phe Glu Ile Ser Phe Gly Gly Ile Pro Thr Pro Gly Arg 
305                 310                 315                 320 


Ser Arg Ala Phe Arg Arg Lys Ser Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Val Thr Glu Leu Ala Lys Lys His Lys Pro 
            340                 345                 350         


Gln Ile Leu Met Met Gly Asn Val Ser Phe Ser Cys Pro Gln Pro Gln 
        355                 360                 365             


Thr Val Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Gly Asn Ser Gly Glu Asp Lys Val Ser Val Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Arg Ala Gly His Leu Leu Phe Gly Glu Leu Arg Arg Gly Ser 
                405                 410                 415     


Gly Ser Phe Val Leu Phe Leu Lys Asp Gly Lys Leu Lys Leu Ser Leu 
            420                 425                 430         


Phe Gln Pro Gly Gln Ser Pro Arg Asn Val Thr Ala Gly Ala Gly Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Phe Ser Ala Lys Trp Ser His 
    450                 455                 460                 


Met Asn Val Val Val Asp Asp Asp Thr Ala Val Gln Pro Leu Val Ala 
465                 470                 475                 480 


Val Leu Ile Asp Ser Gly Asp Thr Tyr Tyr Phe Gly Gly Cys Leu Asp 
                485                 490                 495     


Asn Ser Ser Gly Ser Gly Cys Lys Ser Pro Leu Gly Gly Phe Gln Gly 
            500                 505                 510         


Cys Leu Arg Leu Ile Thr Ile Gly Asp Lys Ala Val Asp Pro Ile Leu 
        515                 520                 525             


Val Gln Gln Gly Ala Leu Gly Ser Phe Arg Asp Leu Gln Ile Asp Ser 
    530                 535                 540                 


Cys Gly Ile Thr Asp Arg Cys Leu Pro Ser Tyr Cys Glu His Gly Gly 
545                 550                 555                 560 


Glu Cys Ser Gln Ser Trp Asp Thr Phe Ser Cys Asp Cys Leu Gly Thr 
                565                 570                 575     


Gly Tyr Thr Gly Glu Thr Cys His Ser Ser Leu Tyr Glu Gln Ser Cys 
            580                 585                 590         


Glu Ala His Lys His Arg Gly Asn Pro Ser Gly Leu Tyr Tyr Ile Asp 
        595                 600                 605             


Ala Asp Gly Ser Gly Pro Leu Gly Pro Phe Leu Val Tyr Cys Asn Met 
    610                 615                 620                 


Thr Ala Asp Ala Ala Trp Thr Val Val Gln His Gly Gly Pro Asp Ala 
625                 630                 635                 640 


Val Thr Leu Arg Gly Ala Pro Ser Gly His Pro Arg Ser Ala Val Ser 
                645                 650                 655     


Phe Ala Tyr Ala Ala Gly Ala Gly Gln Leu Arg Ser Ala Val Asn Leu 
            660                 665                 670         


Ala Glu Arg Cys Glu Gln Arg Leu Ala Leu Arg Cys Gly Thr Ala Arg 
        675                 680                 685             


Arg Pro Asp Ser Arg Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700                 


Thr Asn Glu Thr His Thr Ser Trp Gly Gly Ser Leu Pro Asp Ala Gln 
705                 710                 715                 720 


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735     


Cys Asn Cys Asp Ala Gly Arg Asn Glu Trp Thr Ser Asp Thr Ile Val 
            740                 745                 750         


Leu Ser Gln Lys Glu His Leu Pro Val Thr Gln Ile Val Met Thr Asp 
        755                 760                 765             


Ala Gly Arg Pro His Ser Glu Ala Ala Tyr Thr Leu Gly Pro Leu Leu 
    770                 775                 780                 


Cys Arg Gly Asp Gln Ser Phe Trp Asn Ser Ala Ser Phe Asn Thr Glu 
785                 790                 795                 800 


Thr Ser Tyr Leu His Phe Pro Ala Phe His Gly Glu Leu Thr Ala Asp 
                805                 810                 815     


Val Cys Phe Phe Phe Lys Thr Thr Val Ser Ser Gly Val Phe Met Glu 
            820                 825                 830         


Asn Leu Gly Ile Thr Asp Phe Ile Arg Ile Glu Leu Arg Ala Pro Thr 
        835                 840                 845             


Glu Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Cys Glu Val Thr 
    850                 855                 860                 


Val Gln Ser Pro Thr Pro Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880 


Ala Glu Arg Asn Val Lys Gly Ala Ser Leu Gln Val Asp Gln Leu Pro 
                885                 890                 895     


Gln Lys Met Gln Pro Ala Pro Ala Asp Gly His Val Arg Leu Gln Leu 
            900                 905                 910         


Asn Ser Gln Leu Phe Ile Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925             


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Val Ala Leu Asp Leu 
    930                 935                 940                 


Glu Glu Arg Ala Thr Val Thr Pro Gly Val Glu Pro Gly Cys Ala Gly 
945                 950                 955                 960 


His Cys Ser Thr Tyr Gly His Leu Cys Arg Asn Gly Gly Arg Cys Arg 
                965                 970                 975     


Glu Lys Arg Arg Gly Val Thr Cys Asp Cys Ala Phe Ser Ala Tyr Asp 
            980                 985                 990         


Gly Pro Phe Cys Ser Asn Glu Ile  Ser Ala Tyr Phe Ala  Thr Gly Ser 
        995                 1000                 1005             


Ser Met  Thr Tyr His Phe Gln  Glu His Tyr Thr Leu  Ser Glu Asn 
    1010                 1015                 1020             


Ser Ser  Ser Leu Val Ser Ser  Leu His Arg Asp Val  Thr Leu Thr 
    1025                 1030                 1035             


Arg Glu  Met Ile Thr Leu Ser  Phe Arg Thr Thr Arg  Thr Pro Ser 
    1040                 1045                 1050             


Leu Leu  Leu Tyr Val Ser Ser  Phe Tyr Glu Glu Tyr  Leu Ser Val 
    1055                 1060                 1065             


Ile Leu  Ala Asn Asn Gly Ser  Leu Gln Ile Arg Tyr  Lys Leu Asp 
    1070                 1075                 1080             


Arg His  Gln Asn Pro Asp Ala  Phe Thr Phe Asp Phe  Lys Asn Met 
    1085                 1090                 1095             


Ala Asp  Gly Gln Leu His Gln  Val Lys Ile Asn Arg  Glu Glu Ala 
    1100                 1105                 1110             


Val Val  Met Val Glu Val Asn  Gln Ser Thr Lys Lys  Gln Val Ile 
    1115                 1120                 1125             


Leu Ser  Ser Gly Thr Glu Phe  Asn Ala Val Lys Ser  Leu Ile Leu 
    1130                 1135                 1140             


Gly Lys  Val Leu Glu Ala Ala  Gly Ala Asp Pro Asp  Thr Arg Arg 
    1145                 1150                 1155             


Ala Ala  Thr Ser Gly Phe Thr  Gly Cys Leu Ser Ala  Val Arg Phe 
    1160                 1165                 1170             


Gly Arg  Ala Ala Pro Leu Lys  Ala Ala Leu Arg Pro  Ser Gly Pro 
    1175                 1180                 1185             


Ser Arg  Val Thr Val Arg Gly  His Val Ala Pro Met  Ala Arg Cys 
    1190                 1195                 1200             


Ala Ala  Gly Ala Ala Ser Gly  Ser Pro Ala Arg Glu  Leu Ala Pro 
    1205                 1210                 1215             


Arg Leu  Ala Gly Gly Ala Gly  Arg Ser Gly Pro Ala  Asp Glu Gly 
    1220                 1225                 1230             


Glu Pro  Leu Val Asn Ala Asp  Arg Arg Asp Ser Ala  Val Ile Gly 
    1235                 1240                 1245             


Gly Val  Ile Ala Val Val Ile  Phe Ile Leu Leu Cys  Ile Thr Ala 
    1250                 1255                 1260             


Ile Ala  Ile Arg Ile Tyr Gln  Gln Arg Lys Leu Arg  Lys Glu Asn 
    1265                 1270                 1275             


Glu Ser  Lys Val Ser Lys Lys  Glu Glu Cys 
    1280                 1285             


<210>  2374
<211>  1308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTNAP4__Homo_sapiens__NP_207837

<400>  2374

Met Gly Ser Val Thr Gly Ala Val Leu Lys Thr Leu Leu Leu Leu Ser 
1               5                   10                  15      


Thr Gln Asn Trp Asn Arg Val Glu Ala Gly Asn Ser Tyr Asp Cys Asp 
            20                  25                  30          


Asp Pro Leu Val Ser Ala Leu Pro Gln Ala Ser Phe Ser Ser Ser Ser 
        35                  40                  45              


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ala Arg Leu Asn Arg Arg 
    50                  55                  60                  


Asp Gly Ala Gly Gly Trp Ser Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80  


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95      


Gln Gly Gly Tyr Gly Ser Ser Asn Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110         


Phe Ser Asp Ser Gly Trp Asn Trp Lys Gln Tyr Arg Gln Glu Asp Ser 
        115                 120                 125             


Ile Trp Gly Phe Ser Gly Asn Ala Asn Ala Asp Ser Val Val Tyr Tyr 
    130                 135                 140                 


Arg Leu Gln Pro Ser Ile Lys Ala Arg Phe Leu Arg Phe Ile Pro Leu 
145                 150                 155                 160 


Glu Trp Asn Pro Lys Gly Arg Ile Gly Met Arg Ile Glu Val Phe Gly 
                165                 170                 175     


Cys Ala Tyr Arg Ser Glu Val Val Asp Leu Asp Gly Lys Ser Ser Leu 
            180                 185                 190         


Leu Tyr Arg Phe Asp Gln Lys Ser Leu Ser Pro Ile Lys Asp Ile Ile 
        195                 200                 205             


Ser Leu Lys Phe Lys Thr Met Gln Ser Asp Gly Ile Leu Leu His Arg 
    210                 215                 220                 


Glu Gly Pro Asn Gly Asp His Ile Thr Leu Gln Leu Arg Arg Ala Arg 
225                 230                 235                 240 


Leu Phe Leu Leu Ile Asn Ser Gly Glu Ala Lys Leu Pro Ser Thr Ser 
                245                 250                 255     


Thr Leu Val Asn Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270         


His Ser Val Leu Ile Gln Arg Leu Gly Lys Gln Val Asn Phe Thr Val 
        275                 280                 285             


Asp Glu His Arg His His Phe His Ala Arg Gly Glu Phe Asn Leu Met 
    290                 295                 300                 


Asn Leu Asp Tyr Glu Ile Ser Phe Gly Gly Ile Pro Ala Pro Gly Lys 
305                 310                 315                 320 


Ser Val Ser Phe Pro His Arg Asn Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335     


Tyr Tyr Asn Gly Val Asp Ile Ile Asp Leu Ala Lys Gln Gln Lys Pro 
            340                 345                 350         


Gln Ile Ile Ala Met Gly Asn Val Ser Phe Ser Cys Ser Gln Pro Gln 
        355                 360                 365             


Ser Met Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380                 


Asp Phe Ser Gly Glu Glu Glu Val Ser Ala Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400 


Trp Asn Lys Ala Gly Leu Leu Leu Phe Ser Glu Leu Gln Leu Ile Ser 
                405                 410                 415     


Gly Gly Ile Leu Leu Phe Leu Ser Asp Gly Lys Leu Lys Ser Asn Leu 
            420                 425                 430         


Tyr Gln Pro Gly Lys Leu Pro Ser Asp Ile Thr Ala Gly Val Glu Leu 
        435                 440                 445             


Asn Asp Gly Gln Trp His Ser Val Ser Leu Ser Ala Lys Lys Asn His 
    450                 455                 460                 


Leu Ser Val Ala Val Asp Gly Gln Met Ala Ser Ala Ala Pro Leu Leu 
465                 470                 475                 480 


Gly Pro Glu Gln Ile Tyr Ser Gly Gly Thr Tyr Tyr Phe Gly Gly Cys 
                485                 490                 495     


Pro Asp Lys Ser Phe Gly Ser Lys Cys Lys Ser Pro Leu Gly Gly Phe 
            500                 505                 510         


Gln Gly Cys Met Arg Leu Ile Ser Ile Ser Gly Lys Val Val Asp Leu 
        515                 520                 525             


Ile Ser Val Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu Gln Ile 
    530                 535                 540                 


Asp Ser Cys Gly Ile Ser Asp Arg Cys Leu Pro Asn Tyr Cys Glu His 
545                 550                 555                 560 


Gly Gly Glu Cys Ser Gln Ser Trp Ser Thr Phe His Cys Asn Cys Thr 
                565                 570                 575     


Asn Thr Gly Tyr Arg Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln 
            580                 585                 590         


Ser Cys Glu Ala Tyr Lys His Arg Gly Asn Thr Ser Gly Phe Tyr Tyr 
        595                 600                 605             


Ile Asp Ser Asp Gly Ser Gly Pro Leu Glu Pro Phe Leu Leu Tyr Cys 
    610                 615                 620                 


Asn Met Thr Glu Thr Ala Trp Thr Ile Ile Gln His Asn Gly Ser Asp 
625                 630                 635                 640 


Leu Thr Arg Val Arg Asn Thr Asn Pro Glu Asn Pro Tyr Ala Gly Phe 
                645                 650                 655     


Phe Glu Tyr Val Ala Ser Met Glu Gln Leu Gln Ala Thr Ile Asn Arg 
            660                 665                 670         


Ala Glu His Cys Glu Gln Glu Phe Thr Tyr Tyr Cys Lys Lys Ser Arg 
        675                 680                 685             


Leu Val Asn Lys Gln Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700                 


Thr Asn Glu Thr Gln Thr Tyr Trp Gly Gly Ser Ser Pro Asp Leu Gln 
705                 710                 715                 720 


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735     


Cys Asn Cys Asp Ala Asp Arg Asn Glu Trp Thr Asn Asp Thr Gly Leu 
            740                 745                 750         


Leu Ala Tyr Lys Glu His Leu Pro Val Thr Lys Ile Val Ile Thr Asp 
        755                 760                 765             


Thr Gly Arg Leu His Ser Glu Ala Ala Tyr Lys Leu Gly Pro Leu Leu 
    770                 775                 780                 


Cys Gln Gly Asp Arg Ser Phe Trp Asn Ser Ala Ser Phe Asp Thr Glu 
785                 790                 795                 800 


Ala Ser Tyr Leu His Phe Pro Thr Phe His Gly Glu Leu Ser Ala Asp 
                805                 810                 815     


Val Ser Phe Phe Phe Lys Thr Thr Ala Ser Ser Gly Val Phe Leu Glu 
            820                 825                 830         


Asn Leu Gly Ile Ala Asp Phe Ile Arg Ile Glu Leu Arg Ser Pro Thr 
        835                 840                 845             


Val Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Phe Glu Ile Ser 
    850                 855                 860                 


Val Gln Ser Pro Thr His Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880 


Val Glu Arg Asn Met Lys Glu Ala Ser Leu Gln Val Asp Gln Leu Thr 
                885                 890                 895     


Pro Lys Thr Gln Pro Ala Pro Ala Asp Gly His Val Leu Leu Gln Leu 
            900                 905                 910         


Asn Ser Gln Leu Phe Val Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925             


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Met Thr Leu Asp Leu 
    930                 935                 940                 


Glu Glu Arg Ala Gln Val Thr Pro Glu Val Gln Pro Gly Cys Arg Gly 
945                 950                 955                 960 


His Cys Ser Ser Tyr Gly Lys Leu Cys Arg Asn Gly Gly Lys Cys Arg 
                965                 970                 975     


Glu Arg Pro Ile Gly Phe Phe Cys Asp Cys Thr Phe Ser Ala Tyr Thr 
            980                 985                 990         


Gly Pro Phe Cys Ser Asn Glu Ile  Ser Ala Tyr Phe Gly  Ser Gly Ser 
        995                 1000                 1005             


Ser Val  Ile Tyr Asn Phe Gln  Glu Asn Tyr Leu Leu  Ser Lys Asn 
    1010                 1015                 1020             


Ser Ser  Ser His Ala Ala Ser  Phe His Gly Asp Met  Lys Leu Ser 
    1025                 1030                 1035             


Arg Glu  Met Ile Lys Phe Ser  Phe Arg Thr Thr Arg  Thr Pro Ser 
    1040                 1045                 1050             


Leu Leu  Leu Phe Val Ser Ser  Phe Tyr Lys Glu Tyr  Leu Ser Val 
    1055                 1060                 1065             


Ile Ile  Ala Lys Asn Gly Ser  Leu Gln Ile Arg Tyr  Lys Leu Asn 
    1070                 1075                 1080             


Lys Tyr  Gln Glu Pro Asp Val  Val Asn Phe Asp Phe  Lys Asn Met 
    1085                 1090                 1095             


Ala Asp  Gly Gln Leu His His  Ile Met Ile Asn Arg  Glu Glu Gly 
    1100                 1105                 1110             


Val Val  Phe Ile Glu Ile Asp  Asp Asn Arg Arg Arg  Gln Val His 
    1115                 1120                 1125             


Leu Ser  Ser Gly Thr Glu Phe  Ser Ala Val Lys Ser  Leu Val Leu 
    1130                 1135                 1140             


Gly Arg  Ile Leu Glu His Ser  Asp Val Asp Gln Asp  Thr Ala Leu 
    1145                 1150                 1155             


Ala Gly  Ala Gln Gly Phe Thr  Gly Cys Leu Ser Ala  Val Gln Leu 
    1160                 1165                 1170             


Ser His  Val Ala Pro Leu Lys  Ala Ala Leu His Pro  Ser His Pro 
    1175                 1180                 1185             


Asp Pro  Val Thr Val Thr Gly  His Val Thr Glu Ser  Ser Cys Met 
    1190                 1195                 1200             


Ala Gln  Pro Gly Thr Asp Ala  Thr Ser Arg Glu Arg  Thr His Ser 
    1205                 1210                 1215             


Phe Ala  Asp His Ser Gly Thr  Ile Asp Asp Arg Glu  Pro Leu Ala 
    1220                 1225                 1230             


Asn Ala  Ile Lys Ser Asp Ser  Ala Val Ile Gly Gly  Leu Ile Ala 
    1235                 1240                 1245             


Val Val  Ile Phe Ile Leu Leu  Cys Ile Thr Ala Ile  Ala Val Arg 
    1250                 1255                 1260             


Ile Tyr  Gln Gln Lys Arg Leu  Tyr Lys Arg Ser Glu  Ala Lys Arg 
    1265                 1270                 1275             


Ser Glu  Asn Val Asp Ser Ala  Glu Ala Val Leu Lys  Ser Glu Leu 
    1280                 1285                 1290             


Asn Ile  Gln Asn Ala Val Asn  Glu Asn Gln Lys Glu  Tyr Phe Phe 
    1295                 1300                 1305             


<210>  2375
<211>  1306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTNAP5__Homo_sapiens__NP_570129

<400>  2375

Met Asp Ser Leu Pro Arg Leu Thr Ser Val Leu Thr Leu Leu Phe Ser 
1               5                   10                  15      


Gly Leu Trp His Leu Gly Leu Thr Ala Thr Asn Tyr Asn Cys Asp Asp 
            20                  25                  30          


Pro Leu Ala Ser Leu Leu Ser Pro Met Ala Phe Ser Ser Ser Ser Asp 
        35                  40                  45              


Leu Thr Gly Thr His Ser Pro Ala Gln Leu Asn Trp Arg Val Gly Thr 
    50                  55                  60                  


Gly Gly Trp Ser Pro Ala Asp Ser Asn Ala Gln Gln Trp Leu Gln Met 
65                  70                  75                  80  


Asp Leu Gly Asn Arg Val Glu Ile Thr Ala Val Ala Thr Gln Gly Arg 
                85                  90                  95      


Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Ser Leu Met Phe Ser Asp 
            100                 105                 110         


Thr Gly Arg Asn Trp Lys Gln Tyr Lys Gln Glu Asp Ser Ile Trp Thr 
        115                 120                 125             


Phe Ala Gly Asn Met Asn Ala Asp Ser Val Val His His Lys Leu Leu 
    130                 135                 140                 


His Ser Val Arg Ala Arg Phe Val Arg Phe Val Pro Leu Glu Trp Asn 
145                 150                 155                 160 


Pro Ser Gly Lys Ile Gly Met Arg Val Glu Val Tyr Gly Cys Ser Tyr 
                165                 170                 175     


Lys Ser Asp Val Ala Asp Phe Asp Gly Arg Ser Ser Leu Leu Tyr Arg 
            180                 185                 190         


Phe Asn Gln Lys Leu Met Ser Thr Leu Lys Asp Val Ile Ser Leu Lys 
        195                 200                 205             


Phe Lys Ser Met Gln Gly Asp Gly Val Leu Phe His Gly Glu Gly Gln 
    210                 215                 220                 


Arg Gly Asp His Ile Thr Leu Glu Leu Gln Lys Gly Arg Leu Ala Leu 
225                 230                 235                 240 


His Leu Asn Leu Gly Asp Ser Lys Ala Arg Leu Ser Ser Ser Leu Pro 
                245                 250                 255     


Ser Ala Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp His Ser Val 
            260                 265                 270         


Leu Ile Glu Arg Val Gly Lys Gln Val Asn Phe Thr Val Asp Lys His 
        275                 280                 285             


Thr Gln His Phe Arg Thr Lys Gly Glu Thr Asp Ala Leu Asp Ile Asp 
    290                 295                 300                 


Tyr Glu Leu Ser Phe Gly Gly Ile Pro Val Pro Gly Lys Pro Gly Thr 
305                 310                 315                 320 


Phe Leu Lys Lys Asn Phe His Gly Cys Ile Glu Asn Leu Tyr Tyr Asn 
                325                 330                 335     


Gly Val Asn Ile Ile Asp Leu Ala Lys Arg Arg Lys His Gln Ile Tyr 
            340                 345                 350         


Thr Gly Asn Val Thr Phe Ser Cys Ser Glu Pro Gln Ile Val Pro Ile 
        355                 360                 365             


Thr Phe Val Asn Ser Ser Gly Ser Tyr Leu Leu Leu Pro Gly Thr Pro 
    370                 375                 380                 


Gln Ile Asp Gly Leu Ser Val Ser Phe Gln Phe Arg Thr Trp Asn Lys 
385                 390                 395                 400 


Asp Gly Leu Leu Leu Ser Thr Glu Leu Ser Glu Gly Ser Gly Thr Leu 
                405                 410                 415     


Leu Leu Ser Leu Glu Gly Gly Ile Leu Arg Leu Val Ile Gln Lys Met 
            420                 425                 430         


Thr Glu Arg Val Ala Glu Ile Leu Thr Gly Ser Asn Leu Asn Asp Gly 
        435                 440                 445             


Leu Trp His Ser Val Ser Ile Asn Ala Arg Arg Asn Arg Ile Thr Leu 
    450                 455                 460                 


Thr Leu Asp Asp Glu Ala Ala Pro Pro Ala Pro Asp Ser Thr Trp Val 
465                 470                 475                 480 


Gln Ile Tyr Ser Gly Asn Ser Tyr Tyr Phe Gly Gly Cys Pro Asp Asn 
                485                 490                 495     


Leu Thr Asp Ser Gln Cys Leu Asn Pro Ile Lys Ala Phe Gln Gly Cys 
            500                 505                 510         


Met Arg Leu Ile Phe Ile Asp Asn Gln Pro Lys Asp Leu Ile Ser Val 
        515                 520                 525             


Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu His Ile Asp Leu Cys 
    530                 535                 540                 


Ser Ile Lys Asp Arg Cys Leu Pro Asn Tyr Cys Glu His Gly Gly Ser 
545                 550                 555                 560 


Cys Ser Gln Ser Trp Thr Thr Phe Tyr Cys Asn Cys Ser Asp Thr Ser 
                565                 570                 575     


Tyr Thr Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln Ser Cys Glu 
            580                 585                 590         


Val Tyr Arg His Gln Gly Asn Thr Ala Gly Phe Phe Tyr Ile Asp Ser 
        595                 600                 605             


Asp Gly Ser Gly Pro Leu Gly Pro Leu Gln Val Tyr Cys Asn Ile Thr 
    610                 615                 620                 


Glu Asp Lys Ile Trp Thr Ser Val Gln His Asn Asn Thr Glu Leu Thr 
625                 630                 635                 640 


Arg Val Arg Gly Ala Asn Pro Glu Lys Pro Tyr Ala Met Ala Leu Asp 
                645                 650                 655     


Tyr Gly Gly Ser Met Glu Gln Leu Glu Ala Val Ile Asp Gly Ser Glu 
            660                 665                 670         


His Cys Glu Gln Glu Val Ala Tyr His Cys Arg Arg Ser Arg Leu Leu 
        675                 680                 685             


Asn Thr Pro Asp Gly Thr Pro Phe Thr Trp Trp Ile Gly Arg Ser Asn 
    690                 695                 700                 


Glu Arg His Pro Tyr Trp Gly Gly Ser Pro Pro Gly Val Gln Gln Cys 
705                 710                 715                 720 


Glu Cys Gly Leu Asp Glu Ser Cys Leu Asp Ile Gln His Phe Cys Asn 
                725                 730                 735     


Cys Asp Ala Asp Lys Asp Glu Trp Thr Asn Asp Thr Gly Phe Leu Ser 
            740                 745                 750         


Phe Lys Asp His Leu Pro Val Thr Gln Ile Val Ile Thr Asp Thr Asp 
        755                 760                 765             


Arg Ser Asn Ser Glu Ala Ala Trp Arg Ile Gly Pro Leu Arg Cys Tyr 
    770                 775                 780                 


Gly Asp Arg Arg Phe Trp Asn Ala Val Ser Phe Tyr Thr Glu Ala Ser 
785                 790                 795                 800 


Tyr Leu His Phe Pro Thr Phe His Ala Glu Phe Ser Ala Asp Ile Ser 
                805                 810                 815     


Phe Phe Phe Lys Thr Thr Ala Leu Ser Gly Val Phe Leu Glu Asn Leu 
            820                 825                 830         


Gly Ile Lys Asp Phe Ile Arg Leu Glu Ile Ser Ser Pro Ser Glu Ile 
        835                 840                 845             


Thr Phe Ala Ile Asp Val Gly Asn Gly Pro Val Glu Leu Val Val Gln 
    850                 855                 860                 


Ser Pro Ser Leu Leu Asn Asp Asn Gln Trp His Tyr Val Arg Ala Glu 
865                 870                 875                 880 


Arg Asn Leu Lys Glu Thr Ser Leu Gln Val Asp Asn Leu Pro Arg Ser 
                885                 890                 895     


Thr Arg Glu Thr Ser Glu Glu Gly His Phe Arg Leu Gln Leu Asn Ser 
            900                 905                 910         


Gln Leu Phe Val Gly Gly Thr Ser Ser Arg Gln Lys Gly Phe Leu Gly 
        915                 920                 925             


Cys Ile Arg Ser Leu His Leu Asn Gly Gln Lys Met Asp Leu Glu Glu 
    930                 935                 940                 


Arg Ala Lys Val Thr Ser Gly Val Arg Pro Gly Cys Pro Gly His Cys 
945                 950                 955                 960 


Ser Ser Tyr Gly Ser Ile Cys His Asn Gly Gly Lys Cys Val Glu Lys 
                965                 970                 975     


His Asn Gly Tyr Leu Cys Asp Cys Thr Asn Ser Pro Tyr Glu Gly Pro 
            980                 985                 990         


Phe Cys Lys Lys Glu Val Ser Ala  Val Phe Glu Ala Gly  Thr Ser Val 
        995                 1000                 1005             


Thr Tyr  Met Phe Gln Glu Pro  Tyr Pro Val Thr Lys  Asn Ile Ser 
    1010                 1015                 1020             


Leu Ser  Ser Ser Ala Ile Tyr  Thr Asp Ser Ala Pro  Ser Lys Glu 
    1025                 1030                 1035             


Asn Ile  Ala Leu Ser Phe Val  Thr Thr Gln Ala Pro  Ser Leu Leu 
    1040                 1045                 1050             


Leu Phe  Ile Asn Ser Ser Ser  Gln Asp Phe Val Val  Val Leu Leu 
    1055                 1060                 1065             


Cys Lys  Asn Gly Ser Leu Gln  Val Arg Tyr His Leu  Asn Lys Glu 
    1070                 1075                 1080             


Glu Thr  His Val Phe Thr Ile  Asp Ala Asp Asn Phe  Ala Asn Arg 
    1085                 1090                 1095             


Arg Met  His His Leu Lys Ile  Asn Arg Glu Gly Arg  Glu Leu Thr 
    1100                 1105                 1110             


Ile Gln  Met Asp Gln Gln Leu  Arg Leu Ser Tyr Asn  Phe Ser Pro 
    1115                 1120                 1125             


Glu Val  Glu Phe Arg Val Ile  Arg Ser Leu Thr Leu  Gly Lys Val 
    1130                 1135                 1140             


Thr Glu  Asn Leu Gly Leu Asp  Ser Glu Val Ala Lys  Ala Asn Ala 
    1145                 1150                 1155             


Met Gly  Phe Ala Gly Cys Met  Ser Ser Val Gln Tyr  Asn His Ile 
    1160                 1165                 1170             


Ala Pro  Leu Lys Ala Ala Leu  Arg His Ala Thr Val  Ala Pro Val 
    1175                 1180                 1185             


Thr Val  His Gly Thr Leu Thr  Glu Ser Ser Cys Gly  Phe Met Val 
    1190                 1195                 1200             


Asp Ser  Asp Val Asn Ala Val  Thr Thr Val His Ser  Ser Ser Asp 
    1205                 1210                 1215             


Pro Phe  Gly Lys Thr Asp Glu  Arg Glu Pro Leu Thr  Asn Ala Val 
    1220                 1225                 1230             


Arg Ser  Asp Ser Ala Val Ile  Gly Gly Val Ile Ala  Val Val Ile 
    1235                 1240                 1245             


Phe Ile  Ile Phe Cys Ile Ile  Gly Ile Met Thr Arg  Phe Leu Tyr 
    1250                 1255                 1260             


Gln His  Lys Gln Ser His Arg  Thr Ser Gln Met Lys  Glu Lys Glu 
    1265                 1270                 1275             


Tyr Pro  Glu Asn Leu Asp Ser  Ser Phe Arg Asn Glu  Ile Asp Leu 
    1280                 1285                 1290             


Gln Asn  Thr Val Ser Glu Cys  Lys Arg Glu Tyr Phe  Ile 
    1295                 1300                 1305     


<210>  2376
<211>  2325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTRL__Homo_sapiens__XP_005251736

<400>  2376

Met Lys Lys Gly Ser Gln Gln Lys Ile Phe Ser Lys Ala Lys Ile Pro 
1               5                   10                  15      


Ser Ser Ser His Ser Pro Ile Pro Ser Ser Met Ser Asn Met Arg Ser 
            20                  25                  30          


Arg Ser Leu Ser Pro Leu Ile Gly Ser Glu Thr Leu Pro Phe His Ser 
        35                  40                  45              


Gly Gly Gln Trp Cys Glu Gln Val Glu Ile Ala Asp Glu Asn Asn Met 
    50                  55                  60                  


Leu Leu Asp Tyr Gln Asp His Lys Gly Ala Asp Ser His Ala Gly Val 
65                  70                  75                  80  


Arg Tyr Ile Thr Glu Ala Leu Ile Lys Lys Leu Thr Lys Gln Asp Asn 
                85                  90                  95      


Leu Ala Leu Ile Lys Ser Leu Asn Leu Ser Leu Ser Lys Asp Gly Gly 
            100                 105                 110         


Lys Lys Phe Lys Tyr Ile Glu Asn Leu Glu Lys Cys Val Lys Leu Glu 
        115                 120                 125             


Val Leu Asn Leu Ser Tyr Asn Leu Ile Gly Lys Ile Glu Lys Leu Asp 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Leu Asn Leu Ser Tyr Asn Lys Ile Ser 
145                 150                 155                 160 


Lys Ile Glu Gly Ile Glu Asn Met Cys Asn Leu Gln Lys Leu Asn Leu 
                165                 170                 175     


Ala Gly Asn Glu Ile Glu His Ile Pro Val Trp Leu Gly Lys Lys Leu 
            180                 185                 190         


Lys Ser Leu Arg Val Leu Asn Leu Lys Gly Asn Lys Ile Ser Ser Leu 
        195                 200                 205             


Gln Asp Ile Ser Lys Leu Lys Pro Leu Gln Asp Leu Ile Ser Leu Ile 
    210                 215                 220                 


Leu Val Glu Asn Pro Val Val Thr Leu Pro His Tyr Leu Gln Phe Thr 
225                 230                 235                 240 


Ile Phe His Leu Arg Ser Leu Glu Ser Leu Glu Gly Gln Pro Val Thr 
                245                 250                 255     


Thr Gln Asp Arg Gln Glu Ala Phe Glu Arg Phe Ser Leu Glu Glu Val 
            260                 265                 270         


Glu Arg Leu Glu Arg Asp Leu Glu Lys Lys Met Ile Glu Thr Glu Glu 
        275                 280                 285             


Leu Lys Ser Lys Gln Thr Arg Phe Leu Glu Glu Ile Lys Asn Gln Asp 
    290                 295                 300                 


Lys Leu Asn Lys Ser Leu Lys Glu Glu Ala Met Leu Gln Lys Gln Ser 
305                 310                 315                 320 


Cys Glu Glu Leu Lys Ser Asp Leu Asn Thr Lys Asn Glu Leu Leu Lys 
                325                 330                 335     


Gln Lys Thr Ile Glu Leu Thr Arg Ala Cys Gln Lys Gln Tyr Glu Leu 
            340                 345                 350         


Glu Gln Glu Leu Ala Phe Tyr Lys Ile Asp Ala Lys Phe Glu Pro Leu 
        355                 360                 365             


Asn Tyr Tyr Pro Ser Glu Tyr Ala Glu Ile Asp Lys Ala Pro Asp Glu 
    370                 375                 380                 


Ser Pro Tyr Ile Gly Lys Ser Arg Tyr Lys Arg Asn Met Phe Ala Thr 
385                 390                 395                 400 


Glu Ser Tyr Ile Ile Asp Ser Ala Gln Ala Val Gln Ile Lys Lys Met 
                405                 410                 415     


Glu Pro Asp Glu Gln Leu Arg Asn Asp His Met Asn Leu Arg Gly His 
            420                 425                 430         


Thr Pro Leu Asp Thr Gln Leu Glu Asp Lys Glu Lys Lys Ile Ser Ala 
        435                 440                 445             


Ala Gln Thr Arg Leu Ser Glu Leu His Asp Glu Ile Glu Lys Ala Glu 
    450                 455                 460                 


Gln Gln Ile Leu Arg Ala Thr Glu Glu Phe Lys Gln Leu Glu Glu Ala 
465                 470                 475                 480 


Ile Gln Leu Lys Lys Ile Ser Glu Ala Gly Lys Asp Leu Leu Tyr Lys 
                485                 490                 495     


Gln Leu Ser Gly Arg Leu Gln Leu Val Asn Lys Leu Arg Gln Glu Ala 
            500                 505                 510         


Leu Asp Leu Glu Leu Gln Met Glu Lys Gln Lys Gln Glu Ile Ala Gly 
        515                 520                 525             


Lys Gln Lys Glu Ile Lys Asp Leu Gln Ile Ala Ile Asp Ser Leu Asp 
    530                 535                 540                 


Ser Lys Asp Pro Lys His Ser His Met Lys Ala Gln Lys Ser Gly Lys 
545                 550                 555                 560 


Glu Gln Gln Leu Asp Ile Met Asn Lys Gln Tyr Gln Gln Leu Glu Ser 
                565                 570                 575     


Arg Leu Asp Glu Ile Leu Ser Arg Ile Ala Lys Glu Thr Glu Glu Ile 
            580                 585                 590         


Lys Asp Leu Glu Glu Gln Leu Thr Glu Gly Gln Ile Ala Ala Asn Glu 
        595                 600                 605             


Ala Leu Lys Lys Asp Leu Glu Gly Val Ile Ser Gly Leu Gln Glu Tyr 
    610                 615                 620                 


Leu Gly Thr Ile Lys Gly Gln Ala Thr Gln Ala Gln Asn Glu Cys Arg 
625                 630                 635                 640 


Lys Leu Arg Asp Glu Lys Glu Thr Leu Leu Gln Arg Leu Thr Glu Val 
                645                 650                 655     


Glu Gln Glu Arg Asp Gln Leu Glu Ile Val Ala Met Asp Ala Glu Asn 
            660                 665                 670         


Met Arg Lys Glu Leu Ala Glu Leu Glu Ser Ala Leu Gln Glu Gln His 
        675                 680                 685             


Glu Val Asn Ala Ser Leu Gln Gln Thr Gln Gly Asp Leu Ser Ala Tyr 
    690                 695                 700                 


Glu Ala Glu Leu Glu Ala Arg Leu Asn Leu Arg Asp Ala Glu Ala Asn 
705                 710                 715                 720 


Gln Leu Lys Glu Glu Leu Glu Lys Val Thr Arg Leu Thr Gln Leu Glu 
                725                 730                 735     


Gln Ser Ala Leu Gln Ala Glu Leu Glu Lys Glu Arg Gln Ala Leu Lys 
            740                 745                 750         


Asn Ala Leu Gly Lys Ala Gln Phe Ser Glu Glu Lys Glu Gln Glu Asn 
        755                 760                 765             


Ser Glu Leu His Ala Lys Leu Lys His Leu Gln Asp Asp Asn Asn Leu 
    770                 775                 780                 


Leu Lys Gln Gln Leu Lys Asp Phe Gln Asn His Leu Asn His Val Val 
785                 790                 795                 800 


Asp Gly Leu Val Arg Pro Glu Glu Val Ala Ala Arg Val Asp Glu Leu 
                805                 810                 815     


Arg Arg Lys Leu Lys Leu Gly Thr Gly Glu Met Asn Ile His Ser Pro 
            820                 825                 830         


Ser Asp Val Leu Gly Lys Ser Leu Ala Asp Leu Gln Lys Gln Phe Ser 
        835                 840                 845             


Glu Ile Leu Ala Arg Ser Lys Trp Glu Arg Asp Glu Ala Gln Val Arg 
    850                 855                 860                 


Glu Arg Lys Leu Gln Glu Glu Met Ala Leu Gln Gln Glu Lys Leu Ala 
865                 870                 875                 880 


Thr Gly Gln Glu Glu Phe Arg Gln Ala Cys Glu Arg Ala Leu Glu Ala 
                885                 890                 895     


Arg Met Asn Phe Asp Lys Arg Gln His Glu Ala Arg Ile Gln Gln Met 
            900                 905                 910         


Glu Asn Glu Ile His Tyr Leu Gln Glu Asn Leu Lys Ser Met Glu Glu 
        915                 920                 925             


Ile Gln Gly Leu Thr Asp Leu Gln Leu Gln Glu Ala Asp Glu Glu Lys 
    930                 935                 940                 


Glu Arg Ile Leu Ala Gln Leu Arg Glu Leu Glu Lys Lys Lys Lys Leu 
945                 950                 955                 960 


Glu Asp Ala Lys Ser Gln Glu Gln Val Phe Gly Leu Asp Lys Glu Leu 
                965                 970                 975     


Lys Lys Leu Lys Lys Ala Val Ala Thr Ser Asp Lys Leu Ala Thr Ala 
            980                 985                 990         


Glu Leu Thr Ile Ala Lys Asp Gln  Leu Lys Ser Leu His  Gly Thr Val 
        995                 1000                 1005             


Met Lys  Ile Asn Gln Glu Arg  Ala Glu Glu Leu Gln  Glu Ala Glu 
    1010                 1015                 1020             


Arg Phe  Ser Arg Lys Ala Ala  Gln Ala Ala Arg Asp  Leu Thr Arg 
    1025                 1030                 1035             


Ala Glu  Ala Glu Ile Glu Leu  Leu Gln Asn Leu Leu  Arg Gln Lys 
    1040                 1045                 1050             


Gly Glu  Gln Phe Arg Leu Glu  Met Glu Lys Thr Gly  Val Gly Thr 
    1055                 1060                 1065             


Gly Ala  Asn Ser Gln Val Leu  Glu Ile Glu Lys Leu  Asn Glu Thr 
    1070                 1075                 1080             


Met Glu  Arg Gln Arg Thr Glu  Ile Ala Arg Leu Gln  Asn Val Leu 
    1085                 1090                 1095             


Asp Leu  Thr Gly Ser Asp Asn  Lys Gly Gly Phe Glu  Asn Val Leu 
    1100                 1105                 1110             


Glu Glu  Ile Ala Glu Leu Arg  Arg Glu Val Ser Tyr  Gln Asn Asp 
    1115                 1120                 1125             


Tyr Ile  Ser Ser Met Ala Asp  Pro Phe Lys Arg Arg  Gly Tyr Trp 
    1130                 1135                 1140             


Tyr Phe  Met Pro Pro Pro Pro  Ser Ser Lys Val Ser  Ser His Ser 
    1145                 1150                 1155             


Ser Gln  Ala Thr Lys Asp Ser  Gly Val Gly Leu Lys  Tyr Ser Ala 
    1160                 1165                 1170             


Ser Thr  Pro Val Arg Lys Pro  Arg Pro Gly Gln Gln  Asp Gly Lys 
    1175                 1180                 1185             


Glu Gly  Ser Gln Pro Pro Pro  Ala Ser Gly Tyr Trp  Val Tyr Ser 
    1190                 1195                 1200             


Pro Ile  Arg Ser Gly Leu His  Lys Leu Phe Pro Ser  Arg Asp Ala 
    1205                 1210                 1215             


Asp Ser  Gly Gly Asp Ser Gln  Glu Glu Ser Glu Leu  Asp Asp Gln 
    1220                 1225                 1230             


Glu Glu  Pro Pro Phe Val Pro  Pro Pro Gly Tyr Met  Met Tyr Thr 
    1235                 1240                 1245             


Val Leu  Pro Asp Gly Ser Pro  Val Pro Gln Gly Met  Ala Leu Tyr 
    1250                 1255                 1260             


Ala Pro  Pro Pro Pro Leu Pro  Asn Asn Ser Arg Pro  Leu Thr Pro 
    1265                 1270                 1275             


Gly Thr  Val Val Tyr Gly Pro  Pro Pro Ala Gly Ala  Pro Met Val 
    1280                 1285                 1290             


Tyr Gly  Pro Pro Pro Pro Asn  Phe Ser Ile Pro Phe  Ile Pro Met 
    1295                 1300                 1305             


Gly Val  Leu His Cys Asn Val  Pro Glu His His Asn  Leu Glu Asn 
    1310                 1315                 1320             


Glu Val  Ser Arg Leu Glu Asp  Ile Met Gln His Leu  Lys Ser Lys 
    1325                 1330                 1335             


Lys Arg  Glu Glu Arg Trp Met  Arg Ala Ser Lys Arg  Gln Ser Glu 
    1340                 1345                 1350             


Lys Glu  Met Glu Glu Leu His  His Asn Ile Asp Asp  Leu Leu Gln 
    1355                 1360                 1365             


Glu Lys  Lys Ser Leu Glu Cys  Glu Val Glu Glu Leu  His Arg Thr 
    1370                 1375                 1380             


Val Gln  Lys Arg Gln Gln Gln  Lys Asp Phe Ile Asp  Gly Asn Val 
    1385                 1390                 1395             


Glu Ser  Leu Met Thr Glu Leu  Glu Ile Glu Lys Ser  Leu Lys His 
    1400                 1405                 1410             


His Glu  Asp Ile Val Asp Glu  Ile Glu Cys Ile Glu  Lys Thr Leu 
    1415                 1420                 1425             


Leu Lys  Arg Arg Ser Glu Leu  Arg Glu Ala Asp Arg  Leu Leu Ala 
    1430                 1435                 1440             


Glu Ala  Glu Ser Glu Leu Ser  Cys Thr Lys Glu Lys  Thr Lys Asn 
    1445                 1450                 1455             


Ala Val  Glu Lys Phe Thr Asp  Ala Lys Arg Ser Leu  Leu Gln Thr 
    1460                 1465                 1470             


Glu Ser  Asp Ala Glu Glu Leu  Glu Arg Arg Ala Gln  Glu Thr Ala 
    1475                 1480                 1485             


Val Asn  Leu Val Lys Ala Asp  Gln Gln Leu Arg Ser  Leu Gln Ala 
    1490                 1495                 1500             


Asp Ala  Lys Asp Leu Glu Gln  His Lys Ile Lys Gln  Glu Glu Ile 
    1505                 1510                 1515             


Leu Lys  Glu Ile Asn Lys Ile  Val Ala Ala Lys Asp  Ser Asp Phe 
    1520                 1525                 1530             


Gln Cys  Leu Ser Lys Lys Lys  Glu Lys Leu Thr Glu  Glu Leu Gln 
    1535                 1540                 1545             


Lys Leu  Gln Lys Asp Ile Glu  Met Ala Glu Arg Asn  Glu Asp His 
    1550                 1555                 1560             


His Leu  Gln Val Leu Lys Glu  Ser Glu Val Leu Leu  Gln Ala Lys 
    1565                 1570                 1575             


Arg Ala  Glu Leu Glu Lys Leu  Lys Ser Gln Val Thr  Ser Gln Gln 
    1580                 1585                 1590             


Gln Glu  Met Ala Val Leu Asp  Arg Gln Leu Gly His  Lys Lys Glu 
    1595                 1600                 1605             


Glu Leu  His Leu Leu Gln Gly  Ser Met Val Gln Ala  Lys Ala Asp 
    1610                 1615                 1620             


Leu Gln  Glu Ala Leu Arg Leu  Gly Glu Thr Glu Val  Thr Glu Lys 
    1625                 1630                 1635             


Cys Asn  His Ile Arg Glu Val  Lys Ser Leu Leu Glu  Glu Leu Ser 
    1640                 1645                 1650             


Phe Gln  Lys Gly Glu Leu Asn  Val Gln Ile Ser Glu  Arg Lys Thr 
    1655                 1660                 1665             


Gln Leu  Thr Leu Ile Lys Gln  Glu Ile Glu Lys Glu  Glu Glu Asn 
    1670                 1675                 1680             


Leu Gln  Val Val Leu Arg Gln  Met Ser Lys His Lys  Thr Glu Leu 
    1685                 1690                 1695             


Lys Asn  Ile Leu Asp Met Leu  Gln Leu Glu Asn His  Glu Leu Gln 
    1700                 1705                 1710             


Gly Leu  Lys Leu Gln His Asp  Gln Arg Val Ser Glu  Leu Glu Lys 
    1715                 1720                 1725             


Thr Gln  Val Ala Val Leu Glu  Glu Lys Leu Glu Leu  Glu Asn Leu 
    1730                 1735                 1740             


Gln Gln  Ile Ser Gln Gln Gln  Lys Gly Glu Ile Glu  Trp Gln Lys 
    1745                 1750                 1755             


Gln Leu  Leu Glu Arg Asp Lys  Arg Glu Ile Glu Arg  Met Thr Ala 
    1760                 1765                 1770             


Glu Ser  Arg Ala Leu Gln Ser  Cys Val Glu Cys Leu  Ser Lys Glu 
    1775                 1780                 1785             


Lys Glu  Asp Leu Gln Glu Lys  Cys Asp Ile Trp Glu  Lys Lys Leu 
    1790                 1795                 1800             


Ala Gln  Thr Lys Arg Val Leu  Ala Ala Ala Glu Glu  Asn Ser Lys 
    1805                 1810                 1815             


Met Glu  Gln Ser Asn Leu Glu  Lys Leu Glu Leu Asn  Val Arg Lys 
    1820                 1825                 1830             


Leu Gln  Gln Glu Leu Asp Gln  Leu Asn Arg Asp Lys  Leu Ser Leu 
    1835                 1840                 1845             


His Asn  Asp Ile Ser Ala Met  Gln Gln Gln Leu Gln  Glu Lys Arg 
    1850                 1855                 1860             


Glu Ala  Val Asn Ser Leu Gln  Glu Glu Leu Ala Asn  Val Gln Asp 
    1865                 1870                 1875             


His Leu  Asn Leu Ala Lys Gln  Asp Leu Leu His Thr  Thr Lys His 
    1880                 1885                 1890             


Gln Asp  Val Leu Leu Ser Glu  Gln Thr Arg Leu Gln  Lys Asp Ile 
    1895                 1900                 1905             


Ser Glu  Trp Ala Asn Arg Phe  Glu Asp Cys Gln Lys  Glu Glu Glu 
    1910                 1915                 1920             


Thr Lys  Gln Gln Gln Leu Gln  Val Leu Gln Asn Glu  Ile Glu Glu 
    1925                 1930                 1935             


Asn Lys  Leu Lys Leu Val Gln  Gln Glu Met Met Phe  Gln Arg Leu 
    1940                 1945                 1950             


Gln Lys  Glu Arg Glu Ser Glu  Glu Ser Lys Leu Glu  Thr Ser Lys 
    1955                 1960                 1965             


Val Thr  Leu Lys Glu Gln Gln  His Gln Leu Glu Lys  Glu Leu Thr 
    1970                 1975                 1980             


Asp Gln  Lys Ser Lys Leu Asp  Gln Val Leu Ser Lys  Val Leu Ala 
    1985                 1990                 1995             


Ala Glu  Glu Arg Val Arg Thr  Leu Gln Glu Glu Glu  Arg Trp Cys 
    2000                 2005                 2010             


Glu Ser  Leu Glu Lys Thr Leu  Ser Gln Thr Lys Arg  Gln Leu Ser 
    2015                 2020                 2025             


Glu Arg  Glu Gln Gln Leu Val  Glu Lys Ser Gly Glu  Leu Leu Ala 
    2030                 2035                 2040             


Leu Gln  Lys Glu Ala Asp Ser  Met Arg Ala Asp Phe  Ser Leu Leu 
    2045                 2050                 2055             


Arg Asn  Gln Phe Leu Thr Glu  Arg Lys Lys Ala Glu  Lys Gln Val 
    2060                 2065                 2070             


Ala Ser  Leu Lys Glu Ala Leu  Lys Ile Gln Arg Ser  Gln Leu Glu 
    2075                 2080                 2085             


Lys Asn  Leu Leu Glu Gln Lys  Gln Glu Asn Ser Cys  Ile Gln Lys 
    2090                 2095                 2100             


Glu Met  Ala Thr Ile Glu Leu  Val Ala Gln Asp Asn  His Glu Arg 
    2105                 2110                 2115             


Ala Arg  Arg Leu Met Lys Glu  Leu Asn Gln Met Gln  Tyr Glu Tyr 
    2120                 2125                 2130             


Thr Glu  Leu Lys Lys Gln Met  Ala Asn Gln Lys Asp  Leu Glu Arg 
    2135                 2140                 2145             


Arg Gln  Met Glu Ile Ser Asp  Ala Met Arg Thr Leu  Lys Ser Glu 
    2150                 2155                 2160             


Val Lys  Asp Glu Ile Arg Thr  Ser Leu Lys Asn Leu  Asn Gln Phe 
    2165                 2170                 2175             


Leu Pro  Glu Leu Pro Ala Asp  Leu Glu Ala Ile Leu  Glu Arg Asn 
    2180                 2185                 2190             


Glu Asn  Leu Glu Gly Glu Leu  Glu Ser Leu Lys Glu  Asn Leu Pro 
    2195                 2200                 2205             


Phe Thr  Met Asn Glu Gly Pro  Phe Glu Glu Lys Leu  Asn Phe Ser 
    2210                 2215                 2220             


Gln Val  His Ile Met Asp Glu  His Trp Arg Gly Glu  Ala Leu Arg 
    2225                 2230                 2235             


Glu Lys  Leu Arg His Arg Glu  Asp Arg Leu Lys Ala  Gln Leu Arg 
    2240                 2245                 2250             


His Cys  Met Ser Lys Gln Ala  Glu Val Leu Ile Lys  Gly Lys Arg 
    2255                 2260                 2265             


Gln Thr  Glu Gly Thr Leu His  Ser Leu Arg Arg Gln  Val Asp Ala 
    2270                 2275                 2280             


Leu Gly  Glu Leu Val Thr Ser  Thr Ser Ala Asp Ser  Ala Ser Ser 
    2285                 2290                 2295             


Pro Ser  Leu Ser Gln Leu Glu  Ser Ser Leu Thr Glu  Asp Ser Gln 
    2300                 2305                 2310             


Leu Gly  Gln Asn Gln Glu Lys  Asn Ala Ser Ala Arg  
    2315                 2320                 2325 


<210>  2377
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNTROB__Homo_sapiens__NP_001032221

<400>  2377

Met Ala Thr Ser Ala Asp Ser Pro Ser Ser Pro Leu Gly Ala Glu Asp 
1               5                   10                  15      


Leu Leu Ser Asp Ser Ser Glu Pro Pro Gly Leu Asn Gln Val Ser Ser 
            20                  25                  30          


Glu Val Thr Ser Gln Leu Tyr Ala Ser Leu Arg Leu Ser Arg Gln Ala 
        35                  40                  45              


Glu Ala Thr Ala Arg Ala Gln Leu Tyr Leu Pro Ser Thr Ser Pro Pro 
    50                  55                  60                  


His Glu Gly Leu Asp Gly Phe Ala Gln Glu Leu Ser Arg Ser Leu Ser 
65                  70                  75                  80  


Val Gly Leu Glu Lys Asn Leu Lys Lys Lys Asp Gly Ser Lys His Ile 
                85                  90                  95      


Phe Glu Met Glu Ser Val Arg Gly Gln Leu Gln Thr Met Leu Gln Thr 
            100                 105                 110         


Ser Arg Asp Thr Ala Tyr Arg Asp Pro Leu Ile Pro Gly Ala Gly Ser 
        115                 120                 125             


Glu Arg Arg Glu Glu Asp Ser Phe Asp Ser Asp Ser Thr Ala Thr Leu 
    130                 135                 140                 


Leu Asn Thr Arg Pro Leu Gln Asp Leu Ser Pro Ser Ser Ser Ala Gln 
145                 150                 155                 160 


Ala Leu Glu Glu Leu Phe Pro Arg Tyr Thr Ser Leu Arg Pro Gly Pro 
                165                 170                 175     


Pro Leu Asn Pro Pro Asp Phe Gln Gly Leu Arg Asp Ala Leu Asp Ser 
            180                 185                 190         


Glu His Thr Arg Arg Lys His Cys Glu Arg His Ile Gln Ser Leu Gln 
        195                 200                 205             


Thr Arg Val Leu Glu Leu Gln Gln Gln Leu Ala Val Ala Val Ala Ala 
    210                 215                 220                 


Asp Arg Lys Lys Asp Thr Met Ile Glu Gln Leu Asp Lys Thr Leu Ala 
225                 230                 235                 240 


Arg Val Val Glu Gly Trp Asn Arg His Glu Ala Glu Arg Thr Glu Val 
                245                 250                 255     


Leu Arg Gly Leu Gln Glu Glu His Gln Ala Ala Glu Leu Thr Arg Ser 
            260                 265                 270         


Lys Gln Gln Glu Thr Val Thr Arg Leu Glu Gln Ser Leu Ser Glu Ala 
        275                 280                 285             


Met Glu Ala Leu Asn Arg Glu Gln Glu Ser Ala Arg Leu Gln Gln Arg 
    290                 295                 300                 


Glu Arg Glu Thr Leu Glu Glu Glu Arg Gln Ala Leu Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Ala Glu Gln Gln Arg Cys Cys Val Leu Gln Glu Glu Arg Asp Ala 
                325                 330                 335     


Ala Arg Ala Gly Gln Leu Ser Glu His Arg Glu Leu Glu Thr Leu Arg 
            340                 345                 350         


Ala Ala Leu Glu Glu Glu Arg Gln Thr Trp Ala Gln Gln Glu His Gln 
        355                 360                 365             


Leu Lys Glu His Tyr Gln Ala Leu Gln Glu Glu Ser Gln Ala Gln Leu 
    370                 375                 380                 


Glu Arg Glu Lys Glu Lys Ser Gln Arg Glu Ala Gln Ala Ala Trp Glu 
385                 390                 395                 400 


Thr Gln His Gln Leu Ala Leu Val Gln Ser Glu Val Arg Arg Leu Glu 
                405                 410                 415     


Gly Glu Leu Asp Thr Ala Arg Arg Glu Arg Asp Ala Leu Gln Leu Glu 
            420                 425                 430         


Met Ser Leu Val Gln Ala Arg Tyr Glu Ser Gln Arg Ile Gln Leu Glu 
        435                 440                 445             


Ser Glu Leu Ala Val Gln Leu Glu Gln Arg Val Thr Glu Arg Leu Ala 
    450                 455                 460                 


Gln Ala Gln Glu Ser Ser Leu Arg Gln Ala Ala Ser Leu Arg Glu His 
465                 470                 475                 480 


His Arg Lys Gln Leu Gln Asp Leu Ser Gly Gln His Gln Gln Glu Leu 
                485                 490                 495     


Ala Ser Gln Leu Ala Gln Phe Lys Val Glu Met Ala Glu Arg Glu Glu 
            500                 505                 510         


Arg Gln Gln Gln Val Ala Glu Asp Tyr Glu Leu Arg Leu Ala Arg Glu 
        515                 520                 525             


Gln Ala Arg Val Cys Glu Leu Gln Ser Gly Asn Gln Gln Leu Glu Glu 
    530                 535                 540                 


Gln Arg Val Glu Leu Val Glu Arg Leu Gln Ala Met Leu Gln Ala His 
545                 550                 555                 560 


Trp Asp Glu Ala Asn Gln Leu Leu Ser Thr Thr Leu Pro Pro Pro Asn 
                565                 570                 575     


Pro Pro Ala Pro Pro Ala Gly Pro Ser Ser Pro Gly Pro Gln Glu Pro 
            580                 585                 590         


Glu Lys Glu Glu Arg Arg Val Trp Thr Met Pro Pro Met Ala Val Ala 
        595                 600                 605             


Leu Lys Pro Val Leu Gln Gln Ser Arg Glu Ala Arg Asp Glu Leu Pro 
    610                 615                 620                 


Gly Ala Pro Pro Val Leu Cys Ser Ser Ser Ser Asp Leu Ser Leu Leu 
625                 630                 635                 640 


Leu Gly Pro Ser Phe Gln Ser Gln His Ser Phe Gln Pro Leu Glu Pro 
                645                 650                 655     


Lys Pro Asp Leu Thr Ser Ser Thr Ala Gly Ala Phe Ser Ala Leu Gly 
            660                 665                 670         


Ala Phe His Pro Asp His Arg Ala Glu Arg Pro Phe Pro Glu Glu Asp 
        675                 680                 685             


Pro Gly Pro Asp Gly Glu Gly Leu Leu Lys Gln Gly Leu Pro Pro Ala 
    690                 695                 700                 


Gln Leu Glu Gly Leu Lys Asn Phe Leu His Gln Leu Leu Glu Thr Val 
705                 710                 715                 720 


Pro Gln Asn Asn Glu Asn Pro Ser Val Asp Leu Leu Pro Pro Lys Ser 
                725                 730                 735     


Gly Pro Leu Thr Val Pro Ser Trp Glu Glu Ala Pro Gln Val Pro Arg 
            740                 745                 750         


Ile Pro Pro Pro Val His Lys Thr Lys Val Pro Leu Ala Met Ala Ser 
        755                 760                 765             


Ser Leu Phe Arg Val Pro Glu Pro Pro Ser Ser His Ser Gln Gly Ser 
    770                 775                 780                 


Gly Pro Ser Ser Gly Ser Pro Glu Arg Gly Gly Asp Gly Leu Thr Phe 
785                 790                 795                 800 


Pro Arg Gln Leu Met Glu Val Ser Gln Leu Leu Arg Leu Tyr Gln Ala 
                805                 810                 815     


Arg Gly Trp Gly Ala Leu Pro Ala Glu Asp Leu Leu Leu Tyr Leu Lys 
            820                 825                 830         


Arg Leu Glu His Ser Gly Tyr Lys Pro Gly Arg Lys Glu Glu Gly Phe 
        835                 840                 845             


Ser Gly Trp Lys Leu Asp Tyr Gly Glu Trp Ser Gly Thr Asp Gly Arg 
    850                 855                 860                 


Gly Asp Asn Val Pro Arg Arg Asn Thr Asp Ser Arg Leu Gly Glu Ile 
865                 870                 875                 880 


Pro Arg Lys Glu Ile Pro Ser Gln Ala Val Pro Arg Arg Leu Ala Thr 
                885                 890                 895     


Ala Pro Lys Thr Glu Lys Pro Pro Ala Arg Lys Lys Ser Gly His Pro 
            900                 905                 910         


Ala Pro Ser Ser Met Arg Ser Arg Gly Gly Val Trp Arg 
        915                 920                 925 


<210>  2378
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COA1__Homo_sapiens__NP_060694

<400>  2378

Met Met Trp Gln Lys Tyr Ala Gly Ser Arg Arg Ser Met Pro Leu Gly 
1               5                   10                  15      


Ala Arg Ile Leu Phe His Gly Val Phe Tyr Ala Gly Gly Phe Ala Ile 
            20                  25                  30          


Val Tyr Tyr Leu Ile Gln Lys Phe His Ser Arg Ala Leu Tyr Tyr Lys 
        35                  40                  45              


Leu Ala Val Glu Gln Leu Gln Ser His Pro Glu Ala Gln Glu Ala Leu 
    50                  55                  60                  


Gly Pro Pro Leu Asn Ile His Tyr Leu Lys Leu Ile Asp Arg Glu Asn 
65                  70                  75                  80  


Phe Val Asp Ile Val Asp Ala Lys Leu Lys Ile Pro Val Ser Gly Ser 
                85                  90                  95      


Lys Ser Glu Gly Leu Leu Tyr Val His Ser Ser Arg Gly Gly Pro Phe 
            100                 105                 110         


Gln Arg Trp His Leu Asp Glu Val Phe Leu Glu Leu Lys Asp Gly Gln 
        115                 120                 125             


Gln Ile Pro Val Phe Lys Leu Ser Gly Glu Asn Gly Asp Glu Val Lys 
    130                 135                 140                 


Lys Glu 
145     


<210>  2379
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COA5__Homo_sapiens__NP_001008216

<400>  2379

Met Pro Lys Tyr Tyr Glu Asp Lys Pro Gln Gly Gly Ala Cys Ala Gly 
1               5                   10                  15      


Leu Lys Glu Asp Leu Gly Ala Cys Leu Leu Gln Ser Asp Cys Val Val 
            20                  25                  30          


Gln Glu Gly Lys Ser Pro Arg Gln Cys Leu Lys Glu Gly Tyr Cys Asn 
        35                  40                  45              


Ser Leu Lys Tyr Ala Phe Phe Glu Cys Lys Arg Ser Val Leu Asp Asn 
    50                  55                  60                  


Arg Ala Arg Phe Arg Gly Arg Lys Gly Tyr 
65                  70                  


<210>  2380
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COASY__Homo_sapiens__NP_001035997

<400>  2380

Met Arg Thr Pro Arg Leu Arg Ala Gln Pro Arg Gly Ala Val Tyr Gln 
1               5                   10                  15      


Ala Pro Ser Pro Pro Pro Ala Pro Val Gly Leu Gly Ser Met Ala Val 
            20                  25                  30          


Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala 
        35                  40                  45              


Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His 
    50                  55                  60                  


Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala 
65                  70                  75                  80  


Gln Pro Gln Ser Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe 
                85                  90                  95      


Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val 
            100                 105                 110         


Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro 
        115                 120                 125             


Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu 
    130                 135                 140                 


Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln 
145                 150                 155                 160 


Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu 
                165                 170                 175     


Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val 
            180                 185                 190         


Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro 
        195                 200                 205             


Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala 
    210                 215                 220                 


Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu 
225                 230                 235                 240 


Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala 
                245                 250                 255     


Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro 
            260                 265                 270         


Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys 
        275                 280                 285             


Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro 
    290                 295                 300                 


Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr 
305                 310                 315                 320 


Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu 
                325                 330                 335     


Glu Glu Leu Ala Leu Tyr Gln Ile Gln Leu Leu Lys Asp Leu Arg His 
            340                 345                 350         


Thr Glu Asn Glu Glu Asp Lys Val Ser Ser Ser Ser Phe Arg Gln Arg 
        355                 360                 365             


Met Leu Gly Asn Leu Leu Arg Pro Pro Tyr Glu Arg Pro Glu Leu Pro 
    370                 375                 380                 


Thr Cys Leu Tyr Val Ile Gly Leu Thr Gly Ile Ser Gly Ser Gly Lys 
385                 390                 395                 400 


Ser Ser Ile Ala Gln Arg Leu Lys Gly Leu Gly Ala Phe Val Ile Asp 
                405                 410                 415     


Ser Asp His Leu Gly His Arg Ala Tyr Ala Pro Gly Gly Pro Ala Tyr 
            420                 425                 430         


Gln Pro Val Val Glu Ala Phe Gly Thr Asp Ile Leu His Lys Asp Gly 
        435                 440                 445             


Ile Ile Asn Arg Lys Val Leu Gly Ser Arg Val Phe Gly Asn Lys Lys 
    450                 455                 460                 


Gln Leu Lys Ile Leu Thr Asp Ile Met Trp Pro Ile Ile Ala Lys Leu 
465                 470                 475                 480 


Ala Arg Glu Glu Met Asp Arg Ala Val Ala Glu Gly Lys Arg Val Cys 
                485                 490                 495     


Val Ile Asp Ala Ala Val Leu Leu Glu Ala Gly Trp Gln Asn Leu Val 
            500                 505                 510         


His Glu Val Trp Thr Ala Val Ile Pro Glu Thr Glu Ala Val Arg Arg 
        515                 520                 525             


Ile Val Glu Arg Asp Gly Leu Ser Glu Ala Ala Ala Gln Ser Arg Leu 
    530                 535                 540                 


Gln Ser Gln Met Ser Gly Gln Gln Leu Val Glu Gln Ser His Val Val 
545                 550                 555                 560 


Leu Ser Thr Leu Trp Glu Pro His Ile Thr Gln Arg Gln Val Glu Lys 
                565                 570                 575     


Ala Trp Ala Leu Leu Gln Lys Arg Ile Pro Lys Thr His Gln Ala Leu 
            580                 585                 590         


Asp 
    


<210>  2381
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COBL__Homo_sapiens__NP_001274367

<400>  2381

Met Asp Ala Pro Arg Ala Ser Ala Ala Lys Pro Pro Thr Gly Arg Lys 
1               5                   10                  15      


Met Lys Ala Arg Ala Pro Pro Pro Pro Gly Lys Ala Ala Thr Leu His 
            20                  25                  30          


Val His Ser Asp Gln Lys Pro Pro His Asp Gly Ala Leu Gly Ser Gln 
        35                  40                  45              


Gln Asn Leu Val Arg Met Lys Glu Ala Leu Arg Ala Ser Thr Met Asp 
    50                  55                  60                  


Val Thr Val Val Leu Pro Ser Gly Leu Glu Lys Arg Ser Val Leu Asn 
65                  70                  75                  80  


Gly Ser His Ala Met Met Asp Leu Leu Val Glu Leu Cys Leu Gln Asn 
                85                  90                  95      


His Leu Asn Pro Ser His His Ala Leu Glu Ile Arg Ser Ser Glu Thr 
            100                 105                 110         


Gln Gln Pro Leu Ser Phe Lys Pro Asn Thr Leu Ile Gly Thr Leu Asn 
        115                 120                 125             


Val His Thr Val Phe Leu Lys Glu Lys Val Pro Glu Glu Lys Val Lys 
    130                 135                 140                 


Pro Gly Pro Pro Lys Val Pro Glu Lys Ser Val Arg Leu Val Val Asn 
145                 150                 155                 160 


Tyr Leu Arg Thr Gln Lys Ala Val Val Arg Val Ser Pro Glu Val Pro 
                165                 170                 175     


Leu Gln Asn Ile Leu Pro Val Ile Cys Ala Lys Cys Glu Val Ser Pro 
            180                 185                 190         


Glu His Val Val Leu Leu Arg Asp Asn Ile Ala Gly Glu Glu Leu Glu 
        195                 200                 205             


Leu Ser Lys Ser Leu Asn Glu Leu Gly Ile Lys Glu Leu Tyr Ala Trp 
    210                 215                 220                 


Asp Asn Arg Arg Glu Thr Phe Arg Lys Ser Ser Leu Gly Asn Asp Glu 
225                 230                 235                 240 


Thr Asp Lys Glu Lys Lys Lys Phe Leu Gly Phe Phe Lys Val Asn Lys 
                245                 250                 255     


Arg Ser Asn Ser Lys Gly Cys Leu Thr Thr Pro Asn Ser Pro Ser Met 
            260                 265                 270         


His Ser Arg Ser Leu Thr Leu Gly Pro Ser Leu Ser Leu Gly Ser Ile 
        275                 280                 285             


Ser Gly Val Ser Val Lys Ser Glu Met Lys Lys Arg Arg Ala Pro Pro 
    290                 295                 300                 


Pro Pro Gly Ser Gly Pro Pro Val Gln Asp Lys Ala Ser Glu Lys Val 
305                 310                 315                 320 


Ser Leu Gly Ser Gln Ile Asp Leu Gln Lys Lys Lys Arg Arg Ala Pro 
                325                 330                 335     


Ala Pro Pro Pro Pro Gln Pro Pro Pro Pro Ser Pro Leu Ile Pro Asn 
            340                 345                 350         


Arg Thr Glu Asp Lys Glu Glu Asn Arg Lys Ser Thr Met Val Tyr Cys 
        355                 360                 365             


Cys Ala Ser Phe Pro Thr Gln Ala Lys Arg Phe 
    370                 375                 


<210>  2382
<211>  1233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COBLL1__Homo_sapiens__NP_001265387

<400>  2382

Met Pro Pro Ser Trp Ser Pro Leu Met Cys Gly Arg Ala Ala Glu Ala 
1               5                   10                  15      


Ala Ala Ser Ser Arg Thr Pro Gly Arg Glu Met Gly Gln Ala Val Thr 
            20                  25                  30          


Arg Arg Leu Gly Ala Gly Ala Arg Ala Ala Pro Arg Arg Ala Met Asp 
        35                  40                  45              


Gly Arg Thr Pro Arg Pro Gln Asp Ala Pro Ala Arg Arg Glu Ile Ala 
    50                  55                  60                  


Gly Ser Trp Arg Lys Pro Lys Ala Lys Ala Pro Leu Pro Pro Ala Glu 
65                  70                  75                  80  


Thr Lys Tyr Thr Asp Val Ser Ser Ala Ala Asp Ser Val Glu Ser Thr 
                85                  90                  95      


Ala Phe Ile Met Glu Gln Lys Glu Asn Met Ile Asp Lys Asp Val Glu 
            100                 105                 110         


Leu Ser Val Val Leu Pro Gly Asp Ile Ile Lys Ser Thr Thr Val His 
        115                 120                 125             


Gly Ser Lys Pro Met Met Asp Leu Leu Ile Phe Leu Cys Ala Gln Tyr 
    130                 135                 140                 


His Leu Asn Pro Ser Ser Tyr Thr Ile Asp Leu Leu Ser Ala Glu Gln 
145                 150                 155                 160 


Asn His Ile Lys Phe Lys Pro Asn Thr Pro Ile Gly Met Leu Glu Val 
                165                 170                 175     


Glu Lys Val Ile Leu Lys Pro Lys Met Leu Asp Lys Lys Lys Pro Thr 
            180                 185                 190         


Pro Ile Ile Pro Glu Lys Thr Val Arg Val Val Ile Asn Phe Lys Lys 
        195                 200                 205             


Thr Gln Lys Thr Ile Val Arg Val Ser Pro His Ala Ser Leu Gln Glu 
    210                 215                 220                 


Leu Ala Pro Ile Ile Cys Ser Lys Cys Glu Phe Asp Pro Leu His Thr 
225                 230                 235                 240 


Leu Leu Leu Lys Asp Tyr Gln Ser Gln Glu Pro Leu Asp Leu Thr Lys 
                245                 250                 255     


Ser Leu Asn Asp Leu Gly Leu Arg Glu Leu Tyr Ala Met Asp Val Asn 
            260                 265                 270         


Arg Ala Thr Ser Val Thr Val Phe Ser Lys Ser Ser Leu Gln Glu Ser 
        275                 280                 285             


Cys Gln Ile Ser Gln Asn Leu Asp Ile Met Lys Glu Lys Glu Asn Lys 
    290                 295                 300                 


Gly Phe Phe Ser Phe Phe Gln Arg Ser Lys Lys Lys Arg Asp Gln Thr 
305                 310                 315                 320 


Ala Ser Ala Pro Ala Thr Pro Leu Val Asn Lys His Arg Pro Thr Phe 
                325                 330                 335     


Thr Arg Ser Asn Thr Ile Ser Lys Pro Tyr Ile Ser Asn Thr Leu Pro 
            340                 345                 350         


Ser Asp Ala Pro Lys Lys Arg Arg Ala Pro Leu Pro Pro Met Pro Ala 
        355                 360                 365             


Ser Gln Ser Val Pro Gln Asp Leu Ala His Ile Gln Glu Arg Pro Ala 
    370                 375                 380                 


Ser Cys Ile Val Lys Ser Met Ser Val Asp Glu Thr Asp Lys Ser Pro 
385                 390                 395                 400 


Cys Glu Ala Gly Arg Val Arg Ala Gly Ser Leu Gln Leu Ser Ser Met 
                405                 410                 415     


Ser Ala Gly Asn Ser Ser Leu Arg Arg Thr Lys Arg Lys Ala Pro Ser 
            420                 425                 430         


Pro Pro Ser Lys Ile Pro Pro His Gln Ser Asp Glu Asn Ser Arg Val 
        435                 440                 445             


Thr Ala Leu Gln Pro Val Asp Gly Val Pro Pro Asp Ser Ala Ser Glu 
    450                 455                 460                 


Ala Asn Ser Pro Glu Glu Leu Ser Ser Pro Glu Thr Phe His Pro Gly 
465                 470                 475                 480 


Leu Ser Ser Gln Glu Gln Cys Thr Ala Pro Lys Leu Met Glu Glu Thr 
                485                 490                 495     


Ser Val Phe Glu Cys Pro Gly Thr Pro Glu Ala Ala Ile Thr Ser Leu 
            500                 505                 510         


Thr Ser Gly Ile Ser Ser Asp Tyr Ser Leu Glu Glu Ile Asp Glu Lys 
        515                 520                 525             


Glu Glu Leu Ser Glu Val Pro Lys Val Glu Ala Glu Asn Ile Ser Pro 
    530                 535                 540                 


Lys Ser Gln Asp Ile Pro Phe Val Ser Thr Asp Ile Ile Asn Thr Leu 
545                 550                 555                 560 


Lys Asn Asp Pro Asp Ser Ala Leu Gly Asn Gly Ser Gly Glu Phe Ser 
                565                 570                 575     


Gln Asn Ser Met Glu Glu Lys Gln Glu Thr Lys Ser Thr Asp Gly Gln 
            580                 585                 590         


Glu Pro His Ser Val Val Tyr Asp Thr Ser Asn Gly Lys Lys Val Val 
        595                 600                 605             


Asp Ser Ile Arg Asn Leu Lys Ser Leu Gly Pro Asn Gln Glu Asn Val 
    610                 615                 620                 


Val Gln Asn Glu Ile Ile Val Tyr Pro Glu Asn Thr Glu Asp Asn Met 
625                 630                 635                 640 


Lys Asn Gly Val Lys Lys Thr Glu Ile Asn Val Glu Gly Val Ala Lys 
                645                 650                 655     


Asn Asn Asn Ile Asp Met Glu Val Glu Arg Pro Ser Asn Ser Glu Ala 
            660                 665                 670         


His Glu Thr Asp Thr Ala Ile Ser Tyr Lys Glu Asn His Leu Ala Ala 
        675                 680                 685             


Ser Ser Val Pro Asp Gln Lys Leu Asn Gln Pro Ser Ala Glu Lys Thr 
    690                 695                 700                 


Lys Asp Ala Ala Ile Gln Thr Thr Pro Ser Cys Asn Ser Phe Asp Gly 
705                 710                 715                 720 


Lys His Gln Asp His Asn Leu Ser Asp Ser Lys Val Glu Glu Cys Val 
                725                 730                 735     


Gln Thr Ser Asn Asn Asn Ile Ser Thr Gln His Ser Cys Leu Ser Ser 
            740                 745                 750         


Gln Asp Ser Val Asn Thr Ser Arg Glu Phe Arg Ser Gln Gly Thr Leu 
        755                 760                 765             


Ile Ile His Ser Glu Asp Pro Leu Thr Val Lys Asp Pro Ile Cys Ala 
    770                 775                 780                 


His Gly Asn Asp Asp Leu Leu Pro Pro Val Asp Arg Ile Asp Lys Asn 
785                 790                 795                 800 


Ser Thr Ala Ser Tyr Leu Lys Asn Tyr Pro Leu Tyr Arg Gln Asp Tyr 
                805                 810                 815     


Asn Pro Lys Pro Lys Pro Ser Asn Glu Ile Thr Arg Glu Tyr Ile Pro 
            820                 825                 830         


Lys Ile Gly Met Thr Thr Tyr Lys Ile Val Pro Pro Lys Ser Leu Glu 
        835                 840                 845             


Ile Ser Lys Asp Trp Gln Ser Glu Thr Ile Glu Tyr Lys Asp Asp Gln 
    850                 855                 860                 


Asp Met His Ala Leu Gly Lys Lys His Thr His Glu Asn Val Lys Glu 
865                 870                 875                 880 


Thr Ala Ile Gln Thr Glu Asp Ser Ala Ile Ser Glu Ser Pro Glu Glu 
                885                 890                 895     


Pro Leu Pro Asn Leu Lys Pro Lys Pro Asn Leu Arg Thr Glu His Gln 
            900                 905                 910         


Val Pro Ser Ser Val Ser Ser Pro Asp Asp Ala Met Val Ser Pro Leu 
        915                 920                 925             


Lys Pro Ala Pro Lys Met Thr Arg Asp Thr Gly Thr Ala Pro Phe Ala 
    930                 935                 940                 


Pro Asn Leu Glu Glu Ile Asn Asn Ile Leu Glu Ser Lys Phe Lys Ser 
945                 950                 955                 960 


Arg Ala Ser Asn Ala Gln Ala Lys Pro Ser Ser Phe Phe Leu Gln Met 
                965                 970                 975     


Gln Lys Arg Val Ser Gly His Tyr Val Thr Ser Ala Ala Ala Lys Ser 
            980                 985                 990         


Val His Ala Ala Pro Asn Pro Ala  Pro Lys Glu Leu Thr  Asn Lys Glu 
        995                 1000                 1005             


Ala Glu  Arg Asp Met Leu Pro  Ser Pro Glu Gln Thr  Leu Ser Pro 
    1010                 1015                 1020             


Leu Ser  Lys Met Pro His Ser  Val Pro Gln Pro Leu  Val Glu Lys 
    1025                 1030                 1035             


Thr Asp  Asp Asp Val Ile Gly  Gln Ala Pro Ala Glu  Ala Ser Pro 
    1040                 1045                 1050             


Pro Pro  Ile Ala Pro Lys Pro  Val Thr Ile Pro Ala  Ser Gln Val 
    1055                 1060                 1065             


Ser Thr  Gln Asn Leu Lys Thr  Leu Lys Thr Phe Gly  Ala Pro Arg 
    1070                 1075                 1080             


Pro Tyr  Ser Ser Ser Gly Pro  Ser Pro Phe Ala Leu  Ala Val Val 
    1085                 1090                 1095             


Lys Arg  Ser Gln Ser Phe Ser  Lys Glu Arg Thr Glu  Ser Pro Ser 
    1100                 1105                 1110             


Ala Ser  Ala Leu Val Gln Pro  Pro Ala Asn Thr Glu  Glu Gly Lys 
    1115                 1120                 1125             


Thr His  Ser Val Asn Lys Phe  Val Asp Ile Pro Gln  Leu Gly Val 
    1130                 1135                 1140             


Ser Asp  Lys Glu Asn Asn Ser  Ala His Asn Glu Gln  Asn Ser Gln 
    1145                 1150                 1155             


Ile Pro  Thr Pro Thr Asp Gly  Pro Ser Phe Thr Val  Met Arg Gln 
    1160                 1165                 1170             


Ser Ser  Leu Thr Phe Gln Ser  Ser Asp Pro Glu Gln  Met Arg Gln 
    1175                 1180                 1185             


Ser Leu  Leu Thr Ala Ile Arg  Ser Gly Glu Ala Ala  Ala Lys Leu 
    1190                 1195                 1200             


Lys Arg  Val Thr Ile Pro Ser  Asn Thr Ile Ser Val  Asn Gly Arg 
    1205                 1210                 1215             


Ser Arg  Leu Ser His Ser Met  Ser Pro Asp Ala Gln  Asp Gly His 
    1220                 1225                 1230             


<210>  2383
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COCH__Homo_sapiens__XP_011534841

<400>  2383

Met Ser Ala Ala Trp Ile Pro Ala Leu Gly Leu Gly Val Cys Leu Leu 
1               5                   10                  15      


Leu Leu Pro Gly Pro Ala Gly Ser Glu Gly Ala Ala Pro Ile Ala Ile 
            20                  25                  30          


Thr Cys Phe Thr Arg Gly Leu Asp Ile Arg Lys Glu Lys Ala Asp Val 
        35                  40                  45              


Leu Cys Pro Gly Gly Cys Pro Leu Glu Glu Phe Ser Val Tyr Gly Asn 
    50                  55                  60                  


Ile Val Tyr Ala Ser Val Ser Ser Ile Cys Gly Ala Ala Val His Arg 
65                  70                  75                  80  


Gly Val Ile Ser Asn Ser Gly Gly Pro Val Arg Val Tyr Ser Leu Pro 
                85                  90                  95      


Gly Arg Glu Asn Tyr Ser Ser Val Asp Ala Asn Gly Ile Gln Ser Gln 
            100                 105                 110         


Met Leu Ser Arg Trp Ser Ala Ser Phe Thr Val Thr Lys Gly Lys Ser 
        115                 120                 125             


Ser Thr Gln Glu Ala Thr Gly Gln Ala Val Ser Thr Ala His Pro Pro 
    130                 135                 140                 


Thr Gly Lys Arg Leu Lys Lys Thr Pro Glu Lys Lys Thr Gly Asn Lys 
145                 150                 155                 160 


Asp Cys Lys Ala Asp Ile Ala Phe Leu Ile Asp Gly Ser Phe Asn Ile 
                165                 170                 175     


Gly Gln Arg Arg Phe Asn Leu Gln Lys Asn Phe Val Gly Lys Val Ala 
            180                 185                 190         


Leu Met Leu Gly Ile Gly Thr Glu Gly Pro His Val Gly Leu Val Gln 
        195                 200                 205             


Ala Ser Glu His Pro Lys Ile Glu Phe Tyr Leu Lys Asn Phe Thr Ser 
    210                 215                 220                 


Ala Lys Asp Val Leu Phe Ala Ile Lys Glu Val Gly Phe Arg Gly Gly 
225                 230                 235                 240 


Asn Ser Asn Thr Gly Lys Ala Leu Lys His Thr Ala Gln Lys Phe Phe 
                245                 250                 255     


Thr Val Asp Ala Gly Val Arg Lys Gly Ile Pro Lys Val Val Val Val 
            260                 265                 270         


Phe Ile Asp Gly Trp Pro Ser Asp Asp Ile Glu Glu Ala Gly Ile Val 
        275                 280                 285             


Ala Arg Glu Phe Gly Val Asn Val Phe Ile Val Ser Val Ala Lys Pro 
    290                 295                 300                 


Ile Pro Glu Glu Leu Gly Met Val Gln Asp Val Thr Phe Val Asp Lys 
305                 310                 315                 320 


Ala Val Cys Arg Asn Asn Gly Phe Phe Ser Tyr His Met Pro Asn Trp 
                325                 330                 335     


Phe Gly Thr Thr Lys Tyr Val Lys Pro Leu Val Gln Lys Leu Cys Thr 
            340                 345                 350         


His Glu Gln Met Met Cys Ser Lys Thr Cys Tyr Asn Ser Val Asn Ile 
        355                 360                 365             


Ala Phe Leu Ile Asp Gly Ser Ser Ser Val Gly Asp Ser Asn Phe Arg 
    370                 375                 380                 


Leu Met Leu Glu Phe Val Ser Asn Ile Ala Lys Thr Phe Glu Ile Ser 
385                 390                 395                 400 


Asp Ile Gly Ala Lys Ile Ala Ala Val Gln Phe Thr Tyr Asp Gln Arg 
                405                 410                 415     


Thr Glu Phe Ser Phe Thr Asp Tyr Ser Thr Lys Glu Asn Val Leu Ala 
            420                 425                 430         


Val Ile Arg Asn Ile Arg Tyr Met Ser Gly Gly Thr Ala Thr Gly Asp 
        435                 440                 445             


Ala Ile Ser Phe Thr Val Arg Asn Val Phe Gly Pro Ile Arg Glu Ser 
    450                 455                 460                 


Pro Asn Lys Asn Phe Leu Val Ile Val Thr Asp Gly Gln Ser Tyr Asp 
465                 470                 475                 480 


Asp Val Gln Gly Pro Ala Ala Ala Ala His Asp Ala Gly Ile Thr Ile 
                485                 490                 495     


Phe Ser Val Gly Val Ala Trp Ala Pro Leu Asp Asp Leu Lys Asp Met 
            500                 505                 510         


Ala Ser Lys Pro Lys Glu Ser His Ala Phe Phe Thr Arg Glu Phe Thr 
        515                 520                 525             


Gly Leu Glu Pro Ile Val Ser Asp Val Ile Arg Gly Ile Cys Arg Asp 
    530                 535                 540                 


Phe Leu Glu Ser Gln Gln 
545                 550 


<210>  2384
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG1__Homo_sapiens__NP_061184

<400>  2384

Met Ala Thr Ala Ala Thr Ser Pro Ala Leu Lys Arg Leu Asp Leu Arg 
1               5                   10                  15      


Asp Pro Ala Ala Leu Phe Glu Thr His Gly Ala Glu Glu Ile Arg Gly 
            20                  25                  30          


Leu Glu Arg Gln Val Arg Ala Glu Ile Glu His Lys Lys Glu Glu Leu 
        35                  40                  45              


Arg Gln Met Val Gly Glu Arg Tyr Arg Asp Leu Ile Glu Ala Ala Asp 
    50                  55                  60                  


Thr Ile Gly Gln Met Arg Arg Cys Ala Val Gly Leu Val Asp Ala Val 
65                  70                  75                  80  


Lys Ala Thr Asp Gln Tyr Cys Ala Arg Leu Arg Gln Ala Gly Ser Ala 
                85                  90                  95      


Ala Pro Arg Pro Pro Arg Ala Gln Gln Pro Gln Gln Pro Ser Gln Glu 
            100                 105                 110         


Lys Phe Tyr Ser Met Ala Ala Gln Ile Lys Leu Leu Leu Glu Ile Pro 
        115                 120                 125             


Glu Lys Ile Trp Ser Ser Met Glu Ala Ser Gln Cys Leu His Ala Thr 
    130                 135                 140                 


Gln Leu Tyr Leu Leu Cys Cys His Leu His Ser Leu Leu Gln Leu Asp 
145                 150                 155                 160 


Ser Ser Ser Ser Arg Tyr Ser Pro Val Leu Ser Arg Phe Pro Ile Leu 
                165                 170                 175     


Ile Arg Gln Val Ala Ala Ala Ser His Phe Arg Ser Thr Ile Leu His 
            180                 185                 190         


Glu Ser Lys Met Leu Leu Lys Cys Gln Gly Val Ser Asp Gln Ala Val 
        195                 200                 205             


Ala Glu Ala Leu Cys Ser Ile Met Leu Leu Glu Glu Ser Ser Pro Arg 
    210                 215                 220                 


Gln Ala Leu Thr Asp Phe Leu Leu Ala Arg Lys Ala Thr Ile Gln Lys 
225                 230                 235                 240 


Leu Leu Asn Gln Pro His His Gly Ala Gly Ile Lys Ala Gln Ile Cys 
                245                 250                 255     


Ser Leu Val Glu Leu Leu Ala Thr Thr Leu Lys Gln Ala His Ala Leu 
            260                 265                 270         


Phe Tyr Thr Leu Pro Glu Gly Leu Leu Pro Asp Pro Ala Leu Pro Cys 
        275                 280                 285             


Gly Leu Leu Phe Ser Thr Leu Glu Thr Ile Thr Gly Gln His Pro Ala 
    290                 295                 300                 


Gly Lys Gly Thr Gly Val Leu Gln Glu Glu Met Lys Leu Cys Ser Trp 
305                 310                 315                 320 


Phe Lys His Leu Pro Ala Ser Ile Val Glu Phe Gln Pro Thr Leu Arg 
                325                 330                 335     


Thr Leu Ala His Pro Ile Ser Gln Glu Tyr Leu Lys Asp Thr Leu Gln 
            340                 345                 350         


Lys Trp Ile His Met Cys Asn Glu Asp Ile Lys Asn Gly Ile Thr Asn 
        355                 360                 365             


Leu Leu Met Tyr Val Lys Ser Met Lys Gly Leu Ala Gly Ile Arg Asp 
    370                 375                 380                 


Ala Met Trp Glu Leu Leu Thr Asn Glu Ser Thr Asn His Ser Trp Asp 
385                 390                 395                 400 


Val Leu Cys Arg Arg Leu Leu Glu Lys Pro Leu Leu Phe Trp Glu Asp 
                405                 410                 415     


Met Met Gln Gln Leu Phe Leu Asp Arg Leu Gln Thr Leu Thr Lys Glu 
            420                 425                 430         


Gly Phe Asp Ser Ile Ser Ser Ser Ser Lys Glu Leu Leu Val Ser Ala 
        435                 440                 445             


Leu Gln Glu Leu Glu Ser Ser Thr Ser Asn Ser Pro Ser Asn Lys His 
    450                 455                 460                 


Ile His Phe Glu Tyr Asn Met Ser Leu Phe Leu Trp Ser Glu Ser Pro 
465                 470                 475                 480 


Asn Asp Leu Pro Ser Asp Ala Ala Trp Val Ser Val Ala Asn Arg Gly 
                485                 490                 495     


Gln Phe Ala Ser Ser Gly Leu Ser Met Lys Ala Gln Ala Ile Ser Pro 
            500                 505                 510         


Cys Val Gln Asn Phe Cys Ser Ala Leu Asp Ser Lys Leu Lys Val Lys 
        515                 520                 525             


Leu Asp Asp Leu Leu Ala Tyr Leu Pro Ser Asp Asp Ser Ser Leu Pro 
    530                 535                 540                 


Lys Asp Val Ser Pro Thr Gln Ala Lys Ser Ser Ala Phe Asp Arg Tyr 
545                 550                 555                 560 


Ala Asp Ala Gly Thr Val Gln Glu Met Leu Arg Thr Gln Ser Val Ala 
                565                 570                 575     


Cys Ile Lys His Ile Val Asp Cys Ile Arg Ala Glu Leu Gln Ser Ile 
            580                 585                 590         


Glu Glu Gly Val Gln Gly Gln Gln Asp Ala Leu Asn Ser Ala Lys Leu 
        595                 600                 605             


His Ser Val Leu Phe Met Ala Arg Leu Cys Gln Ser Leu Gly Glu Leu 
    610                 615                 620                 


Cys Pro His Leu Lys Gln Cys Ile Leu Gly Lys Ser Glu Ser Ser Glu 
625                 630                 635                 640 


Lys Pro Ala Arg Glu Phe Arg Ala Leu Arg Lys Gln Gly Lys Val Lys 
                645                 650                 655     


Thr Gln Glu Ile Ile Pro Thr Gln Ala Lys Trp Gln Glu Val Lys Glu 
            660                 665                 670         


Val Leu Leu Gln Gln Ser Val Met Gly Tyr Gln Val Trp Ser Ser Ala 
        675                 680                 685             


Val Val Lys Val Leu Ile His Gly Phe Thr Gln Ser Leu Leu Leu Asp 
    690                 695                 700                 


Asp Ala Gly Ser Val Leu Ala Thr Ala Thr Ser Trp Asp Glu Leu Glu 
705                 710                 715                 720 


Ile Gln Glu Glu Ala Glu Ser Gly Ser Ser Val Thr Ser Lys Ile Arg 
                725                 730                 735     


Leu Pro Ala Gln Pro Ser Trp Tyr Val Gln Ser Phe Leu Phe Ser Leu 
            740                 745                 750         


Cys Gln Glu Ile Asn Arg Val Gly Gly His Ala Leu Pro Lys Val Thr 
        755                 760                 765             


Leu Gln Glu Met Leu Lys Ser Cys Met Val Gln Val Val Ala Ala Tyr 
    770                 775                 780                 


Glu Lys Leu Ser Glu Glu Lys Gln Ile Lys Lys Glu Gly Ala Phe Pro 
785                 790                 795                 800 


Val Thr Gln Asn Arg Ala Leu Gln Leu Leu Tyr Asp Leu Arg Tyr Leu 
                805                 810                 815     


Asn Ile Val Leu Thr Ala Lys Gly Asp Glu Val Lys Ser Gly Arg Ser 
            820                 825                 830         


Lys Pro Asp Ser Arg Ile Glu Lys Val Thr Asp His Leu Glu Ala Leu 
        835                 840                 845             


Ile Asp Pro Phe Asp Leu Asp Val Phe Thr Pro His Leu Asn Ser Asn 
    850                 855                 860                 


Leu His Arg Leu Val Gln Arg Thr Ser Val Leu Phe Gly Leu Val Thr 
865                 870                 875                 880 


Gly Thr Glu Asn Gln Leu Ala Pro Arg Ser Ser Thr Phe Asn Ser Gln 
                885                 890                 895     


Glu Pro His Asn Ile Leu Pro Leu Ala Ser Ser Gln Ile Arg Phe Gly 
            900                 905                 910         


Leu Leu Pro Leu Ser Met Thr Ser Thr Arg Lys Ala Lys Ser Thr Arg 
        915                 920                 925             


Asn Ile Glu Thr Lys Ala Gln Val Val Pro Pro Ala Arg Ser Thr Ala 
    930                 935                 940                 


Gly Asp Pro Thr Val Pro Gly Ser Leu Phe Arg Gln Leu Val Ser Glu 
945                 950                 955                 960 


Glu Asp Asn Thr Ser Ala Pro Ser Leu Phe Lys Leu Gly Trp Leu Ser 
                965                 970                 975     


Ser Met Thr Lys 
            980 


<210>  2385
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG2__Homo_sapiens__NP_001138508

<400>  2385

Met Glu Lys Ser Arg Met Asn Leu Pro Lys Gly Pro Asp Thr Leu Cys 
1               5                   10                  15      


Phe Asp Lys Asp Glu Phe Met Lys Glu Asp Phe Asp Val Asp His Phe 
            20                  25                  30          


Val Ser Asp Cys Arg Lys Arg Val Gln Leu Glu Glu Leu Arg Asp Asp 
        35                  40                  45              


Leu Glu Leu Tyr Tyr Lys Leu Leu Lys Thr Ala Met Val Glu Leu Ile 
    50                  55                  60                  


Asn Lys Asp Tyr Ala Asp Phe Val Asn Leu Ser Thr Asn Leu Val Gly 
65                  70                  75                  80  


Met Asp Lys Ala Leu Asn Gln Leu Ser Val Pro Leu Gly Gln Leu Arg 
                85                  90                  95      


Glu Glu Val Leu Ser Leu Arg Ser Ser Val Ser Glu Gly Ile Arg Ala 
            100                 105                 110         


Val Asp Glu Arg Met Ser Lys Gln Glu Asp Ile Arg Lys Lys Lys Met 
        115                 120                 125             


Cys Val Leu Arg Leu Ile Gln Val Ile Arg Ser Val Glu Lys Ile Glu 
    130                 135                 140                 


Lys Ile Leu Asn Ser Gln Ser Ser Lys Glu Thr Ser Ala Leu Glu Ala 
145                 150                 155                 160 


Ser Ser Pro Leu Leu Thr Gly Gln Ile Leu Glu Arg Ile Ala Thr Glu 
                165                 170                 175     


Phe Asn Gln Leu Gln Phe His Ala Val Gln Ser Lys Gly Met Pro Leu 
            180                 185                 190         


Leu Asp Lys Val Arg Pro Arg Ile Ala Gly Ile Thr Ala Met Leu Gln 
        195                 200                 205             


Gln Ser Leu Glu Gly Leu Leu Leu Glu Gly Leu Gln Thr Ser Asp Val 
    210                 215                 220                 


Asp Ile Ile Arg His Cys Leu Arg Thr Tyr Ala Thr Ile Asp Lys Thr 
225                 230                 235                 240 


Arg Asp Ala Glu Ala Leu Val Gly Gln Val Leu Val Lys Pro Tyr Ile 
                245                 250                 255     


Asp Glu Val Ile Ile Glu Gln Phe Val Glu Ser His Pro Asn Gly Leu 
            260                 265                 270         


Gln Val Met Tyr Asn Lys Leu Leu Glu Phe Val Pro His His Cys Arg 
        275                 280                 285             


Leu Leu Arg Glu Val Thr Gly Gly Ala Ile Ser Ser Glu Lys Gly Asn 
    290                 295                 300                 


Thr Val Pro Gly Tyr Asp Phe Leu Val Asn Ser Val Trp Pro Gln Ile 
305                 310                 315                 320 


Val Gln Gly Leu Glu Glu Lys Leu Pro Ser Leu Phe Asn Pro Gly Asn 
                325                 330                 335     


Pro Asp Ala Phe His Glu Lys Tyr Thr Ile Ser Met Asp Phe Val Arg 
            340                 345                 350         


Arg Leu Glu Arg Gln Cys Gly Ser Gln Ala Ser Val Lys Arg Leu Arg 
        355                 360                 365             


Ala His Pro Ala Tyr His Ser Phe Asn Lys Lys Trp Asn Leu Pro Val 
    370                 375                 380                 


Tyr Phe Gln Ile Arg Phe Arg Glu Ile Ala Gly Ser Leu Glu Ala Ala 
385                 390                 395                 400 


Leu Thr Asp Val Leu Glu Asp Ala Pro Ala Glu Ser Pro Tyr Cys Leu 
                405                 410                 415     


Leu Ala Ser His Arg Thr Trp Ser Ser Leu Arg Arg Cys Trp Ser Asp 
            420                 425                 430         


Glu Met Phe Leu Pro Leu Leu Val His Arg Leu Trp Arg Leu Thr Leu 
        435                 440                 445             


Gln Ile Leu Ala Arg Tyr Ser Val Phe Val Asn Glu Leu Ser Leu Arg 
    450                 455                 460                 


Pro Ile Ser Asn Glu Ser Pro Lys Glu Ile Lys Lys Pro Leu Val Thr 
465                 470                 475                 480 


Gly Ser Lys Glu Pro Ser Ile Thr Gln Gly Asn Thr Glu Asp Gln Gly 
                485                 490                 495     


Ser Gly Pro Ser Glu Thr Lys Pro Val Val Ser Ile Ser Arg Thr Gln 
            500                 505                 510         


Leu Val Tyr Val Val Ala Asp Leu Asp Lys Leu Gln Glu Gln Leu Pro 
        515                 520                 525             


Glu Leu Leu Glu Ile Ile Lys Pro Lys Leu Glu Met Ile Gly Phe Lys 
    530                 535                 540                 


Asn Phe Ser Ser Ile Ser Ala Leu Glu Asp Ser Gln Ser Ser Phe Ser 
545                 550                 555                 560 


Ala Cys Val Pro Ser Leu Ser Ser Lys Ile Ile Gln Asp Leu Ser Asp 
                565                 570                 575     


Ser Cys Phe Gly Phe Leu Lys Ser Ala Leu Glu Val Pro Arg Leu Tyr 
            580                 585                 590         


Arg Arg Thr Asn Lys Glu Val Pro Thr Thr Ala Ser Ser Tyr Val Asp 
        595                 600                 605             


Ser Ala Leu Lys Pro Leu Phe Gln Leu Gln Ser Gly His Lys Asp Lys 
    610                 615                 620                 


Leu Lys Gln Ala Ile Ile Gln Gln Trp Leu Glu Gly Thr Leu Ser Glu 
625                 630                 635                 640 


Ser Thr His Lys Tyr Tyr Glu Thr Val Ser Asp Val Leu Asn Ser Val 
                645                 650                 655     


Lys Lys Met Glu Glu Ser Leu Lys Arg Leu Lys Gln Ala Arg Lys Thr 
            660                 665                 670         


Thr Pro Ala Asn Pro Val Gly Pro Ser Gly Gly Met Ser Asp Asp Asp 
        675                 680                 685             


Lys Ile Arg Leu Gln Leu Ala Leu Asp Val Glu Tyr Leu Gly Glu Gln 
    690                 695                 700                 


Ile Gln Lys Leu Gly Leu Gln Ala Ser Asp Ile Lys Ser Phe Ser Ala 
705                 710                 715                 720 


Leu Ala Glu Leu Val Ala Ala Ala Lys Asp Gln Ala Thr Ala Glu Gln 
                725                 730                 735     


Pro 
    


<210>  2386
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG3__Homo_sapiens__NP_113619

<400>  2386

Met Ala Glu Ala Ala Leu Leu Leu Leu Pro Glu Ala Ala Ala Glu Arg 
1               5                   10                  15      


Asp Ala Arg Glu Lys Leu Ala Leu Trp Asp Arg Arg Pro Asp Thr Thr 
            20                  25                  30          


Ala Pro Leu Thr Asp Arg Gln Thr Asp Ser Val Leu Glu Leu Lys Ala 
        35                  40                  45              


Ala Ala Glu Asn Leu Pro Val Pro Ala Glu Leu Pro Ile Glu Asp Leu 
    50                  55                  60                  


Cys Ser Leu Thr Ser Gln Ser Leu Pro Ile Glu Leu Thr Ser Val Val 
65                  70                  75                  80  


Pro Glu Ser Thr Glu Asp Ile Leu Leu Lys Gly Phe Thr Ser Leu Gly 
                85                  90                  95      


Met Glu Glu Glu Arg Ile Glu Thr Ala Gln Gln Phe Phe Ser Trp Phe 
            100                 105                 110         


Ala Lys Leu Gln Thr Gln Met Asp Gln Asp Glu Gly Thr Lys Tyr Arg 
        115                 120                 125             


Gln Met Arg Asp Tyr Leu Ser Gly Phe Gln Glu Gln Cys Asp Ala Ile 
    130                 135                 140                 


Leu Asn Asp Val Asn Ser Ala Leu Gln His Leu Glu Ser Leu Gln Lys 
145                 150                 155                 160 


Gln Tyr Leu Phe Val Ser Asn Lys Thr Gly Thr Leu His Glu Ala Cys 
                165                 170                 175     


Glu Gln Leu Leu Lys Glu Gln Ser Glu Leu Val Asp Leu Ala Glu Asn 
            180                 185                 190         


Ile Gln Gln Lys Leu Ser Tyr Phe Asn Glu Leu Glu Thr Ile Asn Thr 
        195                 200                 205             


Lys Leu Asn Ser Pro Thr Leu Ser Val Asn Ser Asp Gly Phe Ile Pro 
    210                 215                 220                 


Met Leu Ala Lys Leu Asp Asp Cys Ile Thr Tyr Ile Ser Ser His Pro 
225                 230                 235                 240 


Asn Phe Lys Asp Tyr Pro Ile Tyr Leu Leu Lys Phe Lys Gln Cys Leu 
                245                 250                 255     


Ser Lys Ala Leu His Leu Met Lys Thr Tyr Thr Val Asn Thr Leu Gln 
            260                 265                 270         


Thr Leu Thr Ser Gln Leu Leu Lys Arg Asp Pro Ser Ser Val Pro Asn 
        275                 280                 285             


Ala Asp Asn Ala Phe Thr Leu Phe Tyr Val Lys Phe Arg Ala Ala Ala 
    290                 295                 300                 


Pro Lys Val Arg Thr Leu Ile Glu Gln Ile Glu Leu Arg Ser Glu Lys 
305                 310                 315                 320 


Ile Pro Glu Tyr Gln Gln Leu Leu Asn Asp Ile His Gln Cys Tyr Leu 
                325                 330                 335     


Asp Gln Arg Glu Leu Leu Leu Gly Pro Ser Ile Ala Cys Thr Val Ala 
            340                 345                 350         


Glu Leu Thr Ser Gln Asn Asn Arg Asp His Cys Ala Leu Val Arg Ser 
        355                 360                 365             


Gly Cys Ala Phe Met Val His Val Cys Gln Asp Glu His Gln Leu Tyr 
    370                 375                 380                 


Asn Glu Phe Phe Thr Lys Pro Thr Ser Lys Leu Asp Glu Leu Leu Glu 
385                 390                 395                 400 


Lys Leu Cys Val Ser Leu Tyr Asp Val Phe Arg Pro Leu Ile Ile His 
                405                 410                 415     


Val Ile His Leu Glu Thr Leu Ser Glu Leu Cys Gly Ile Leu Lys Asn 
            420                 425                 430         


Glu Val Leu Glu Asp His Val Gln Asn Asn Ala Glu Gln Leu Gly Ala 
        435                 440                 445             


Phe Ala Ala Gly Val Lys Gln Met Leu Glu Asp Val Gln Glu Arg Leu 
    450                 455                 460                 


Val Tyr Arg Thr His Ile Tyr Ile Gln Thr Asp Ile Thr Gly Tyr Lys 
465                 470                 475                 480 


Pro Ala Pro Gly Asp Leu Ala Tyr Pro Asp Lys Leu Val Met Met Glu 
                485                 490                 495     


Gln Ile Ala Gln Ser Leu Lys Asp Glu Gln Lys Lys Val Pro Ser Glu 
            500                 505                 510         


Ala Ser Phe Ser Asp Val His Leu Glu Glu Gly Glu Ser Asn Ser Leu 
        515                 520                 525             


Thr Lys Ser Gly Ser Thr Glu Ser Leu Asn Pro Arg Pro Gln Thr Thr 
    530                 535                 540                 


Ile Ser Pro Ala Asp Leu His Gly Met Trp Tyr Pro Thr Val Arg Arg 
545                 550                 555                 560 


Thr Leu Val Cys Leu Ser Lys Leu Tyr Arg Cys Ile Asp Arg Ala Val 
                565                 570                 575     


Phe Gln Gly Leu Ser Gln Glu Ala Leu Ser Ala Cys Ile Gln Ser Leu 
            580                 585                 590         


Leu Gly Ala Ser Glu Ser Ile Ser Lys Asn Lys Thr Gln Ile Asp Gly 
        595                 600                 605             


Gln Leu Phe Leu Ile Lys His Leu Leu Ile Leu Arg Glu Gln Ile Ala 
    610                 615                 620                 


Pro Phe His Thr Glu Phe Thr Ile Lys Glu Ile Ser Leu Asp Leu Lys 
625                 630                 635                 640 


Lys Thr Arg Asp Ala Ala Phe Lys Ile Leu Asn Pro Met Thr Val Pro 
                645                 650                 655     


Arg Phe Phe Arg Leu Asn Ser Asn Asn Ala Leu Ile Glu Phe Leu Leu 
            660                 665                 670         


Glu Gly Thr Pro Glu Ile Arg Glu His Tyr Leu Asp Ser Lys Lys Asp 
        675                 680                 685             


Val Asp Arg His Leu Lys Ser Ala Cys Glu Gln Phe Ile Gln Gln Gln 
    690                 695                 700                 


Thr Lys Leu Phe Val Glu Gln Leu Glu Glu Phe Met Thr Lys Val Ser 
705                 710                 715                 720 


Ala Leu Lys Thr Met Ala Ser Gln Gly Gly Pro Lys Tyr Thr Leu Ser 
                725                 730                 735     


Gln Gln Pro Trp Ala Gln Pro Ala Lys Val Asn Asp Leu Ala Ala Thr 
            740                 745                 750         


Ala Tyr Lys Thr Ile Lys Thr Lys Leu Pro Val Thr Leu Arg Ser Met 
        755                 760                 765             


Ser Leu Tyr Leu Ser Asn Lys Asp Thr Glu Phe Ile Leu Phe Lys Pro 
    770                 775                 780                 


Val Arg Asn Asn Ile Gln Gln Val Phe Gln Lys Phe His Ala Leu Leu 
785                 790                 795                 800 


Lys Glu Glu Phe Ser Pro Glu Asp Ile Gln Ile Ile Ala Cys Pro Ser 
                805                 810                 815     


Met Glu Gln Leu Ser Leu Leu Leu Ser Val Ser Lys 
            820                 825             


<210>  2387
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG4__Homo_sapiens__NP_001182068

<400>  2387

Met Gly Thr Lys Met Ala Asp Leu Asp Ser Pro Pro Lys Leu Ser Gly 
1               5                   10                  15      


Val Gln Gln Pro Ser Glu Gly Val Gly Gly Gly Arg Cys Ser Glu Ile 
            20                  25                  30          


Ser Ala Glu Leu Ile Arg Ser Leu Thr Glu Leu Gln Glu Leu Glu Ala 
        35                  40                  45              


Val Tyr Glu Arg Leu Cys Gly Glu Glu Lys Val Val Glu Arg Glu Leu 
    50                  55                  60                  


Asp Ala Leu Leu Glu Gln Gln Asn Thr Ile Glu Ser Lys Met Val Thr 
65                  70                  75                  80  


Leu His Arg Met Gly Pro Asn Leu Gln Leu Ile Glu Gly Asp Ala Lys 
                85                  90                  95      


Gln Leu Ala Gly Met Ile Thr Phe Thr Cys Asn Leu Ala Glu Asn Val 
            100                 105                 110         


Ser Ser Lys Val Arg Gln Leu Asp Leu Ala Lys Asn Arg Leu Tyr Gln 
        115                 120                 125             


Ala Ile Gln Arg Ala Asp Asp Ile Leu Asp Leu Lys Phe Cys Met Asp 
    130                 135                 140                 


Gly Val Gln Thr Ala Leu Arg Ser Glu Asp Tyr Glu Gln Ala Ala Ala 
145                 150                 155                 160 


His Thr His Arg Tyr Leu Cys Leu Asp Lys Ser Val Ile Glu Leu Ser 
                165                 170                 175     


Arg Gln Gly Lys Glu Gly Ser Met Ile Asp Ala Asn Leu Lys Leu Leu 
            180                 185                 190         


Gln Glu Ala Glu Gln Arg Leu Lys Ala Ile Val Ala Glu Lys Phe Ala 
        195                 200                 205             


Ile Ala Thr Lys Glu Gly Asp Leu Pro Gln Val Glu Arg Phe Phe Lys 
    210                 215                 220                 


Ile Phe Pro Leu Leu Gly Leu His Glu Glu Gly Leu Arg Lys Phe Ser 
225                 230                 235                 240 


Glu Tyr Leu Cys Lys Gln Val Ala Ser Lys Ala Glu Glu Asn Leu Leu 
                245                 250                 255     


Met Val Leu Gly Thr Asp Met Ser Asp Arg Arg Ala Ala Val Ile Phe 
            260                 265                 270         


Ala Asp Thr Leu Thr Leu Leu Phe Glu Gly Ile Ala Arg Ile Val Glu 
        275                 280                 285             


Thr His Gln Pro Ile Val Glu Thr Tyr Tyr Gly Pro Gly Arg Leu Tyr 
    290                 295                 300                 


Thr Leu Ile Lys Tyr Leu Gln Val Glu Cys Asp Arg Gln Val Glu Lys 
305                 310                 315                 320 


Val Val Asp Lys Phe Ile Lys Gln Arg Asp Tyr His Gln Gln Phe Arg 
                325                 330                 335     


His Val Gln Asn Asn Leu Met Arg Asn Ser Thr Thr Glu Lys Ile Glu 
            340                 345                 350         


Pro Arg Glu Leu Asp Pro Ile Leu Thr Glu Val Thr Leu Met Asn Ala 
        355                 360                 365             


Arg Ser Glu Leu Tyr Leu Arg Phe Leu Lys Lys Arg Ile Ser Ser Asp 
    370                 375                 380                 


Phe Glu Val Gly Asp Ser Met Ala Ser Glu Glu Val Lys Gln Glu His 
385                 390                 395                 400 


Gln Lys Cys Leu Asp Lys Leu Leu Asn Asn Cys Leu Leu Ser Cys Thr 
                405                 410                 415     


Met Gln Glu Leu Ile Gly Leu Tyr Val Thr Met Glu Glu Tyr Phe Met 
            420                 425                 430         


Arg Glu Thr Val Asn Lys Ala Val Ala Leu Asp Thr Tyr Glu Lys Gly 
        435                 440                 445             


Gln Leu Thr Ser Ser Met Val Asp Asp Val Phe Tyr Ile Val Lys Lys 
    450                 455                 460                 


Cys Ile Gly Arg Ala Leu Ser Ser Ser Ser Ile Asp Cys Leu Cys Ala 
465                 470                 475                 480 


Met Ile Asn Leu Ala Thr Thr Glu Leu Glu Ser Asp Phe Arg Asp Val 
                485                 490                 495     


Leu Cys Asn Lys Leu Arg Met Gly Phe Pro Ala Thr Thr Phe Gln Asp 
            500                 505                 510         


Ile Gln Arg Gly Val Thr Ser Ala Val Asn Ile Met His Ser Ser Leu 
        515                 520                 525             


Gln Gln Gly Lys Phe Asp Thr Lys Gly Ile Glu Ser Thr Asp Glu Ala 
    530                 535                 540                 


Lys Met Ser Phe Leu Ser Asp Cys Thr Lys Leu Phe Ser Gln Gly Ile 
545                 550                 555                 560 


Gly Gly Glu Gln Ala Gln Ala Lys Phe Asp Ser Cys Leu Ser Asp Leu 
                565                 570                 575     


Ala Ala Val Ser Asn Lys Phe Arg Asp Leu Leu Gln Glu Gly Leu Thr 
            580                 585                 590         


Glu Leu Asn Ser Thr Ala Ile Lys Pro Gln Val Gln Pro Trp Ile Asn 
        595                 600                 605             


Ser Phe Phe Ser Val Ser His Asn Ile Glu Glu Glu Glu Phe Asn Asp 
    610                 615                 620                 


Tyr Glu Ala Asn Asp Pro Trp Val Gln Gln Phe Ile Leu Asn Leu Glu 
625                 630                 635                 640 


Gln Gln Met Ala Glu Phe Lys Ala Ser Leu Ser Pro Val Ile Tyr Asp 
                645                 650                 655     


Ser Leu Thr Gly Leu Met Thr Ser Leu Val Ala Val Glu Leu Glu Lys 
            660                 665                 670         


Val Val Leu Lys Ser Thr Phe Asn Arg Leu Gly Gly Leu Gln Phe Asp 
        675                 680                 685             


Lys Glu Leu Arg Ser Leu Ile Ala Tyr Leu Thr Thr Val Thr Thr Trp 
    690                 695                 700                 


Thr Ile Arg Asp Lys Phe Ala Arg Leu Ser Gln Met Ala Thr Ile Leu 
705                 710                 715                 720 


Asn Leu Glu Arg Val Thr Glu Ile Leu Asp Tyr Trp Gly Pro Asn Ser 
                725                 730                 735     


Gly Pro Leu Thr Trp Arg Leu Thr Pro Ala Glu Val Arg Gln Val Leu 
            740                 745                 750         


Ala Leu Arg Ile Asp Phe Arg Ser Glu Asp Ile Lys Arg Leu Arg Leu 
        755                 760                 765             


<210>  2388
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG5__Homo_sapiens__NP_006339

<400>  2388

Met Gly Trp Val Gly Gly Arg Arg Arg Asp Ser Ala Ser Pro Pro Gly 
1               5                   10                  15      


Arg Ser Arg Ser Ala Ala Asp Asp Ile Asn Pro Ala Pro Ala Asn Met 
            20                  25                  30          


Glu Gly Gly Gly Gly Ser Val Ala Val Ala Gly Leu Gly Ala Arg Gly 
        35                  40                  45              


Ser Gly Ala Ala Ala Ala Thr Val Arg Glu Leu Leu Gln Asp Gly Cys 
    50                  55                  60                  


Tyr Ser Asp Phe Leu Asn Glu Asp Phe Asp Val Lys Thr Tyr Thr Ser 
65                  70                  75                  80  


Gln Ser Ile His Gln Ala Val Ile Ala Glu Gln Leu Ala Lys Leu Ala 
                85                  90                  95      


Gln Gly Ile Ser Gln Leu Asp Arg Glu Leu His Leu Gln Val Val Ala 
            100                 105                 110         


Arg His Glu Asp Leu Leu Ala Gln Ala Thr Gly Ile Glu Ser Leu Glu 
        115                 120                 125             


Gly Val Leu Gln Met Met Gln Thr Arg Ile Gly Ala Leu Gln Gly Ala 
    130                 135                 140                 


Val Asp Arg Ile Lys Ala Lys Ile Val Glu Pro Tyr Asn Lys Ile Val 
145                 150                 155                 160 


Ala Arg Thr Ala Gln Leu Ala Arg Leu Gln Val Ala Cys Asp Leu Leu 
                165                 170                 175     


Arg Arg Ile Ile Arg Ile Leu Asn Leu Ser Lys Arg Leu Gln Gly Gln 
            180                 185                 190         


Leu Gln Gly Gly Ser Arg Glu Ile Thr Lys Ala Ala Gln Ser Leu Asn 
        195                 200                 205             


Glu Leu Asp Tyr Leu Ser Gln Gly Ile Asp Leu Ser Gly Ile Glu Val 
    210                 215                 220                 


Ile Glu Asn Asp Leu Leu Phe Ile Ala Arg Ala Arg Leu Glu Val Glu 
225                 230                 235                 240 


Asn Gln Ala Lys Arg Leu Leu Glu Gln Gly Leu Glu Thr Gln Asn Pro 
                245                 250                 255     


Thr Gln Val Gly Thr Ala Leu Gln Val Phe Tyr Asn Leu Gly Thr Leu 
            260                 265                 270         


Lys Asp Thr Ile Thr Ser Val Val Asp Gly Tyr Cys Ala Thr Leu Glu 
        275                 280                 285             


Glu Asn Ile Asn Ser Ala Leu Asp Ile Lys Val Leu Thr Gln Pro Ser 
    290                 295                 300                 


Gln Ser Ala Val Arg Gly Gly Pro Gly Arg Ser Thr Met Pro Thr Pro 
305                 310                 315                 320 


Gly Asn Thr Ala Ala Leu Arg Ala Ser Phe Trp Thr Asn Met Glu Lys 
                325                 330                 335     


Leu Met Asp His Ile Tyr Ala Val Cys Gly Gln Val Gln His Leu Gln 
            340                 345                 350         


Lys Val Leu Ala Lys Lys Arg Asp Pro Val Ser His Ile Cys Phe Ile 
        355                 360                 365             


Glu Glu Ile Val Lys Asp Gly Gln Pro Glu Ile Phe Tyr Thr Phe Trp 
    370                 375                 380                 


Asn Ser Val Thr Gln Ala Leu Ser Ser Gln Phe His Met Ala Thr Asn 
385                 390                 395                 400 


Ser Ser Met Phe Leu Lys Gln Ala Phe Glu Gly Glu Tyr Pro Lys Leu 
                405                 410                 415     


Leu Arg Leu Tyr Asn Asp Leu Trp Lys Arg Leu Gln Gln Tyr Ser Gln 
            420                 425                 430         


His Ile Gln Gly Asn Phe Asn Ala Ser Gly Thr Thr Asp Leu Tyr Val 
        435                 440                 445             


Asp Leu Gln His Met Glu Asp Asp Ala Gln Asp Ile Phe Ile Pro Lys 
    450                 455                 460                 


Lys Pro Asp Tyr Asp Pro Glu Lys Ala Leu Lys Asp Ser Leu Gln Pro 
465                 470                 475                 480 


Tyr Glu Ala Ala Tyr Leu Ser Lys Ser Leu Ser Arg Leu Phe Asp Pro 
                485                 490                 495     


Ile Asn Leu Val Phe Pro Pro Gly Gly Arg Asn Pro Pro Ser Ser Asp 
            500                 505                 510         


Glu Leu Asp Gly Ile Ile Lys Thr Ile Ala Ser Glu Leu Asn Val Ala 
        515                 520                 525             


Ala Val Asp Thr Asn Leu Thr Leu Ala Val Ser Lys Asn Val Ala Lys 
    530                 535                 540                 


Thr Ile Gln Leu Tyr Ser Val Lys Ser Glu Gln Leu Leu Ser Thr Gln 
545                 550                 555                 560 


Gly Asp Ala Ser Gln Val Ile Gly Pro Leu Thr Glu Gly Gln Arg Arg 
                565                 570                 575     


Asn Val Ala Val Val Asn Ser Leu Tyr Lys Leu His Gln Ser Val Thr 
            580                 585                 590         


Lys Val Val Ser Ser Gln Ser Ser Phe Pro Leu Ala Ala Glu Gln Thr 
        595                 600                 605             


Ile Ile Ser Ala Leu Lys Ala Ile His Ala Leu Met Glu Asn Ala Val 
    610                 615                 620                 


Gln Pro Leu Leu Thr Ser Val Gly Asp Ala Ile Glu Ala Ile Ile Ile 
625                 630                 635                 640 


Thr Met His Gln Glu Asp Phe Ser Gly Ser Leu Ser Ser Ser Gly Lys 
                645                 650                 655     


Pro Asp Val Pro Cys Ser Leu Tyr Met Lys Glu Leu Gln Gly Phe Ile 
            660                 665                 670         


Ala Arg Val Met Ser Asp Tyr Phe Lys His Phe Glu Cys Leu Asp Phe 
        675                 680                 685             


Val Phe Asp Asn Thr Glu Ala Ile Ala Gln Arg Ala Val Glu Leu Phe 
    690                 695                 700                 


Ile Arg His Ala Ser Leu Ile Arg Pro Leu Gly Glu Gly Gly Lys Met 
705                 710                 715                 720 


Arg Leu Ala Ala Asp Phe Ala Gln Met Glu Leu Ala Val Gly Pro Phe 
                725                 730                 735     


Cys Arg Arg Val Ser Asp Leu Gly Lys Ser Tyr Arg Met Leu Arg Ser 
            740                 745                 750         


Phe Arg Pro Leu Leu Phe Gln Ala Ser Glu His Val Ala Ser Ser Pro 
        755                 760                 765             


Ala Leu Gly Asp Val Ile Pro Phe Ser Ile Ile Ile Gln Phe Leu Phe 
    770                 775                 780                 


Thr Arg Ala Pro Ala Glu Leu Lys Ser Pro Phe Gln Arg Ala Glu Trp 
785                 790                 795                 800 


Ser His Thr Arg Phe Ser Gln Trp Leu Asp Asp His Pro Ser Glu Lys 
                805                 810                 815     


Asp Arg Leu Leu Leu Ile Arg Gly Ala Leu Glu Ala Tyr Val Gln Ser 
            820                 825                 830         


Val Arg Ser Arg Glu Gly Lys Glu Phe Ala Pro Val Tyr Pro Ile Met 
        835                 840                 845             


Val Gln Leu Leu Gln Lys Ala Met Ser Ala Leu Gln 
    850                 855                 860 


<210>  2389
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG6__Homo_sapiens__NP_001138551

<400>  2389

Met Ala Glu Gly Ser Gly Glu Val Val Ala Val Ser Ala Thr Gly Ala 
1               5                   10                  15      


Ala Asn Gly Leu Asn Asn Gly Ala Gly Gly Thr Ser Ala Thr Thr Cys 
            20                  25                  30          


Asn Pro Leu Ser Arg Lys Leu His Lys Ile Leu Glu Thr Arg Leu Asp 
        35                  40                  45              


Asn Asp Lys Glu Met Leu Glu Ala Leu Lys Ala Leu Ser Thr Phe Phe 
    50                  55                  60                  


Val Glu Asn Ser Leu Arg Thr Arg Arg Asn Leu Arg Gly Asp Ile Glu 
65                  70                  75                  80  


Arg Lys Ser Leu Ala Ile Asn Glu Glu Phe Val Ser Ile Phe Lys Glu 
                85                  90                  95      


Val Lys Glu Glu Leu Glu Ser Ile Ser Glu Asp Val Gln Ala Met Ser 
            100                 105                 110         


Asn Cys Cys Gln Asp Met Thr Ser Arg Leu Gln Ala Ala Lys Glu Gln 
        115                 120                 125             


Thr Gln Asp Leu Ile Val Lys Thr Thr Lys Leu Gln Ser Glu Ser Gln 
    130                 135                 140                 


Lys Leu Glu Ile Arg Ala Gln Val Ala Asp Ala Phe Leu Ser Lys Phe 
145                 150                 155                 160 


Gln Leu Thr Ser Asp Glu Met Ser Leu Leu Arg Gly Thr Arg Glu Gly 
                165                 170                 175     


Pro Ile Thr Glu Asp Phe Phe Lys Ala Leu Gly Arg Val Lys Gln Ile 
            180                 185                 190         


His Asn Asp Val Lys Val Leu Leu Arg Thr Asn Gln Gln Thr Ala Gly 
        195                 200                 205             


Leu Glu Ile Met Glu Gln Met Ala Leu Leu Gln Glu Thr Ala Tyr Glu 
    210                 215                 220                 


Arg Leu Tyr Arg Trp Ala Gln Ser Glu Cys Arg Thr Leu Thr Gln Glu 
225                 230                 235                 240 


Ser Cys Asp Val Ser Pro Val Leu Thr Gln Ala Met Glu Ala Leu Gln 
                245                 250                 255     


Asp Arg Pro Val Leu Tyr Lys Tyr Thr Leu Asp Glu Phe Gly Thr Ala 
            260                 265                 270         


Arg Arg Ser Thr Val Val Arg Gly Phe Ile Asp Ala Leu Thr Arg Gly 
        275                 280                 285             


Gly Pro Gly Gly Thr Pro Arg Pro Ile Glu Met His Ser His Asp Pro 
    290                 295                 300                 


Leu Arg Tyr Val Gly Asp Met Leu Ala Trp Leu His Gln Ala Thr Ala 
305                 310                 315                 320 


Ser Glu Lys Glu His Leu Glu Ala Leu Leu Lys His Val Thr Thr Gln 
                325                 330                 335     


Gly Val Glu Glu Asn Ile Gln Glu Val Val Gly His Ile Thr Glu Gly 
            340                 345                 350         


Val Cys Arg Pro Leu Lys Val Arg Ile Glu Gln Val Ile Val Ala Glu 
        355                 360                 365             


Pro Gly Ala Val Leu Leu Tyr Lys Ile Ser Asn Leu Leu Lys Phe Tyr 
    370                 375                 380                 


His His Thr Ile Ser Gly Ile Val Gly Asn Ser Ala Thr Ala Leu Leu 
385                 390                 395                 400 


Thr Thr Ile Glu Glu Met His Leu Leu Ser Lys Lys Ile Phe Phe Asn 
                405                 410                 415     


Ser Leu Ser Leu His Ala Ser Lys Leu Met Asp Lys Val Glu Leu Pro 
            420                 425                 430         


Pro Pro Asp Leu Gly Pro Ser Ser Ala Leu Asn Gln Thr Leu Met Leu 
        435                 440                 445             


Leu Arg Glu Val Leu Ala Ser His Asp Ser Ser Val Val Pro Leu Asp 
    450                 455                 460                 


Ala Arg Gln Ala Asp Phe Val Gln Val Leu Ser Cys Val Leu Asp Pro 
465                 470                 475                 480 


Leu Leu Gln Met Cys Thr Val Ser Ala Ser Asn Leu Gly Thr Ala Asp 
                485                 490                 495     


Met Ala Thr Phe Met Val Asn Ser Leu Tyr Met Met Lys Thr Thr Leu 
            500                 505                 510         


Ala Leu Phe Glu Phe Thr Asp Arg Arg Leu Glu Met Leu Gln Phe Gln 
        515                 520                 525             


Ile Glu Ala His Leu Asp Thr Leu Ile Asn Glu Gln Ala Ser Tyr Val 
    530                 535                 540                 


Leu Thr Arg Val Gly Leu Ser Tyr Ile Tyr Asn Thr Val Gln Gln His 
545                 550                 555                 560 


Lys Pro Glu Gln Gly Ser Leu Ala Asn Met Pro Asn Leu Asp Ser Val 
                565                 570                 575     


Thr Leu Lys Ala Ala Met Val Gln Phe Asp Arg Tyr Leu Ser Ala Pro 
            580                 585                 590         


Asp Asn Leu Leu Ile Pro Gln Leu Asn Phe Leu Leu Ser Ala Thr Val 
        595                 600                 605             


Lys Arg Pro Pro Asn Gly Pro 
    610                 615 


<210>  2390
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG7__Homo_sapiens__NP_705831

<400>  2390

Met Asp Phe Ser Lys Phe Leu Ala Asp Asp Phe Asp Val Lys Glu Trp 
1               5                   10                  15      


Ile Asn Ala Ala Phe Arg Ala Gly Ser Lys Glu Ala Ala Ser Gly Lys 
            20                  25                  30          


Ala Asp Gly His Ala Ala Thr Leu Val Met Lys Leu Gln Leu Phe Ile 
        35                  40                  45              


Gln Glu Val Asn His Ala Val Glu Glu Thr Ser His Gln Ala Leu Gln 
    50                  55                  60                  


Asn Met Pro Lys Val Leu Arg Asp Val Glu Ala Leu Lys Gln Glu Ala 
65                  70                  75                  80  


Ser Phe Leu Lys Glu Gln Met Ile Leu Val Lys Glu Asp Ile Lys Lys 
                85                  90                  95      


Phe Glu Gln Asp Thr Ser Gln Ser Met Gln Val Leu Val Glu Ile Asp 
            100                 105                 110         


Gln Val Lys Ser Arg Met Gln Leu Ala Ala Glu Ser Leu Gln Glu Ala 
        115                 120                 125             


Asp Lys Trp Ser Thr Leu Ser Ala Asp Ile Glu Glu Thr Phe Lys Thr 
    130                 135                 140                 


Gln Asp Ile Ala Val Ile Ser Ala Lys Leu Thr Gly Met Gln Asn Ser 
145                 150                 155                 160 


Leu Met Met Leu Val Asp Thr Pro Asp Tyr Ser Glu Lys Cys Val His 
                165                 170                 175     


Leu Glu Ala Leu Lys Asn Arg Leu Glu Ala Leu Ala Ser Pro Gln Ile 
            180                 185                 190         


Val Ala Ala Phe Thr Ser Gln Ala Val Asp Gln Ser Lys Val Phe Val 
        195                 200                 205             


Lys Val Phe Thr Glu Ile Asp Arg Met Pro Gln Leu Leu Ala Tyr Tyr 
    210                 215                 220                 


Tyr Lys Cys His Lys Val Gln Leu Leu Ala Ala Trp Gln Glu Leu Cys 
225                 230                 235                 240 


Gln Ser Asp Leu Ser Leu Asp Arg Gln Leu Thr Gly Leu Tyr Asp Ala 
                245                 250                 255     


Leu Leu Gly Ala Trp His Thr Gln Ile Gln Trp Ala Thr Gln Val Phe 
            260                 265                 270         


Gln Lys Pro His Glu Val Val Met Val Leu Leu Ile Gln Thr Leu Gly 
        275                 280                 285             


Ala Leu Met Pro Ser Leu Pro Ser Cys Leu Ser Asn Gly Val Glu Arg 
    290                 295                 300                 


Ala Gly Pro Glu Gln Glu Leu Thr Arg Leu Leu Glu Phe Tyr Asp Ala 
305                 310                 315                 320 


Thr Ala His Phe Ala Lys Gly Leu Glu Met Ala Leu Leu Pro His Leu 
                325                 330                 335     


His Glu His Asn Leu Val Lys Val Thr Glu Leu Val Asp Ala Val Tyr 
            340                 345                 350         


Asp Pro Tyr Lys Pro Tyr Gln Leu Lys Tyr Gly Asp Met Glu Glu Ser 
        355                 360                 365             


Asn Leu Leu Ile Gln Met Ser Ala Val Pro Leu Glu His Gly Glu Val 
    370                 375                 380                 


Ile Asp Cys Val Gln Glu Leu Ser His Ser Val Asn Lys Leu Phe Gly 
385                 390                 395                 400 


Leu Ala Ser Ala Ala Val Asp Arg Cys Val Arg Phe Thr Asn Gly Leu 
                405                 410                 415     


Gly Thr Cys Gly Leu Leu Ser Ala Leu Lys Ser Leu Phe Ala Lys Tyr 
            420                 425                 430         


Val Ser Asp Phe Thr Ser Thr Leu Gln Ser Ile Arg Lys Lys Cys Lys 
        435                 440                 445             


Leu Asp His Ile Pro Pro Asn Ser Leu Phe Gln Glu Asp Trp Thr Ala 
    450                 455                 460                 


Phe Gln Asn Ser Ile Arg Ile Ile Ala Thr Cys Gly Glu Leu Leu Arg 
465                 470                 475                 480 


His Cys Gly Asp Phe Glu Gln Gln Leu Ala Asn Arg Ile Leu Ser Thr 
                485                 490                 495     


Ala Gly Lys Tyr Leu Ser Asp Ser Cys Ser Pro Arg Ser Leu Ala Gly 
            500                 505                 510         


Phe Gln Glu Ser Ile Leu Thr Asp Lys Lys Asn Ser Ala Lys Asn Pro 
        515                 520                 525             


Trp Gln Glu Tyr Asn Tyr Leu Gln Lys Asp Asn Pro Ala Glu Tyr Ala 
    530                 535                 540                 


Ser Leu Met Glu Ile Leu Tyr Thr Leu Lys Glu Lys Gly Ser Ser Asn 
545                 550                 555                 560 


His Asn Leu Leu Ala Ala Pro Arg Ala Ala Leu Thr Arg Leu Asn Gln 
                565                 570                 575     


Gln Ala His Gln Leu Ala Phe Asp Ser Val Phe Leu Arg Ile Lys Gln 
            580                 585                 590         


Gln Leu Leu Leu Ile Ser Lys Met Asp Ser Trp Asn Thr Ala Gly Ile 
        595                 600                 605             


Gly Glu Thr Leu Thr Asp Glu Leu Pro Ala Phe Ser Leu Thr Pro Leu 
    610                 615                 620                 


Glu Tyr Ile Ser Asn Ile Gly Gln Tyr Ile Met Ser Leu Pro Leu Asn 
625                 630                 635                 640 


Leu Glu Pro Phe Val Thr Gln Glu Asp Ser Ala Leu Glu Leu Ala Leu 
                645                 650                 655     


His Ala Gly Lys Leu Pro Phe Pro Pro Glu Gln Gly Asp Glu Leu Pro 
            660                 665                 670         


Glu Leu Asp Asn Met Ala Asp Asn Trp Leu Gly Ser Ile Ala Arg Ala 
        675                 680                 685             


Thr Met Gln Thr Tyr Cys Asp Ala Ile Leu Gln Ile Pro Glu Leu Ser 
    690                 695                 700                 


Pro His Ser Ala Lys Gln Leu Ala Thr Asp Ile Asp Tyr Leu Ile Asn 
705                 710                 715                 720 


Val Met Asp Ala Leu Gly Leu Gln Pro Ser Arg Thr Leu Gln His Ile 
                725                 730                 735     


Val Thr Leu Leu Lys Thr Arg Pro Glu Asp Tyr Arg Gln Val Ser Lys 
            740                 745                 750         


Gly Leu Pro Arg Arg Leu Ala Thr Thr Val Ala Thr Met Arg Ser Val 
        755                 760                 765             


Asn Tyr 
    770 


<210>  2391
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COG8__Homo_sapiens__NP_115758

<400>  2391

Met Ala Thr Ala Ala Thr Ile Pro Ser Val Ala Thr Ala Thr Ala Ala 
1               5                   10                  15      


Ala Leu Gly Glu Val Glu Asp Glu Gly Leu Leu Ala Ser Leu Phe Arg 
            20                  25                  30          


Asp Arg Phe Pro Glu Ala Gln Trp Arg Glu Arg Pro Asp Val Gly Arg 
        35                  40                  45              


Tyr Leu Arg Glu Leu Ser Gly Ser Gly Leu Glu Arg Leu Arg Arg Glu 
    50                  55                  60                  


Pro Glu Arg Leu Ala Glu Glu Arg Ala Gln Leu Leu Gln Gln Thr Arg 
65                  70                  75                  80  


Asp Leu Ala Phe Ala Asn Tyr Lys Thr Phe Ile Arg Gly Ala Glu Cys 
                85                  90                  95      


Thr Glu Arg Ile His Arg Leu Phe Gly Asp Val Glu Ala Ser Leu Gly 
            100                 105                 110         


Arg Leu Leu Asp Arg Leu Pro Ser Phe Gln Gln Ser Cys Arg Asn Phe 
        115                 120                 125             


Val Lys Glu Ala Glu Glu Ile Ser Ser Asn Arg Arg Met Asn Ser Leu 
    130                 135                 140                 


Thr Leu Asn Arg His Thr Glu Ile Leu Glu Ile Leu Glu Ile Pro Gln 
145                 150                 155                 160 


Leu Met Asp Thr Cys Val Arg Asn Ser Tyr Tyr Glu Glu Ala Leu Glu 
                165                 170                 175     


Leu Ala Ala Tyr Val Arg Arg Leu Glu Arg Lys Tyr Ser Ser Ile Pro 
            180                 185                 190         


Val Ile Gln Gly Ile Val Asn Glu Val Arg Gln Ser Met Gln Leu Met 
        195                 200                 205             


Leu Ser Gln Leu Ile Gln Gln Leu Arg Thr Asn Ile Gln Leu Pro Ala 
    210                 215                 220                 


Cys Leu Arg Val Ile Gly Tyr Leu Arg Arg Met Asp Val Phe Thr Glu 
225                 230                 235                 240 


Ala Glu Leu Arg Val Lys Phe Leu Gln Ala Arg Asp Ala Trp Leu Arg 
                245                 250                 255     


Ser Ile Leu Thr Ala Ile Pro Asn Asp Asp Pro Tyr Phe His Ile Thr 
            260                 265                 270         


Lys Thr Ile Glu Ala Ser Arg Val His Leu Phe Asp Ile Ile Thr Gln 
        275                 280                 285             


Tyr Arg Ala Ile Phe Ser Asp Glu Asp Pro Leu Leu Pro Pro Ala Met 
    290                 295                 300                 


Gly Glu His Thr Val Asn Glu Ser Ala Ile Phe His Gly Trp Val Leu 
305                 310                 315                 320 


Gln Lys Val Ser Gln Phe Leu Gln Val Leu Glu Thr Asp Leu Tyr Arg 
                325                 330                 335     


Gly Ile Gly Gly His Leu Asp Ser Leu Leu Gly Gln Cys Met Tyr Phe 
            340                 345                 350         


Gly Leu Ser Phe Ser Arg Val Gly Ala Asp Phe Arg Gly Gln Leu Ala 
        355                 360                 365             


Pro Val Phe Gln Arg Val Ala Ile Ser Thr Phe Gln Lys Ala Ile Gln 
    370                 375                 380                 


Glu Thr Val Glu Lys Phe Gln Glu Glu Met Asn Ser Tyr Met Leu Ile 
385                 390                 395                 400 


Ser Ala Pro Ala Ile Leu Gly Thr Ser Asn Met Pro Ala Ala Val Pro 
                405                 410                 415     


Ala Thr Gln Pro Gly Thr Leu Gln Pro Pro Met Val Leu Leu Asp Phe 
            420                 425                 430         


Pro Pro Leu Ala Cys Phe Leu Asn Asn Ile Leu Val Ala Phe Asn Asp 
        435                 440                 445             


Leu Arg Leu Cys Cys Pro Val Ala Leu Ala Gln Asp Val Thr Gly Ala 
    450                 455                 460                 


Leu Glu Asp Ala Leu Ala Lys Val Thr Lys Ile Ile Leu Ala Phe His 
465                 470                 475                 480 


Arg Ala Glu Glu Ala Ala Phe Ser Ser Gly Glu Gln Glu Leu Phe Val 
                485                 490                 495     


Gln Phe Cys Thr Val Phe Leu Glu Asp Leu Val Pro Tyr Leu Asn Arg 
            500                 505                 510         


Cys Leu Gln Val Leu Phe Pro Pro Ala Gln Ile Ala Gln Thr Leu Gly 
        515                 520                 525             


Ile Pro Pro Thr Gln Leu Ser Lys Tyr Gly Asn Leu Gly His Val Asn 
    530                 535                 540                 


Ile Gly Ala Ile Gln Glu Pro Leu Ala Phe Ile Leu Pro Lys Arg Glu 
545                 550                 555                 560 


Thr Leu Phe Thr Leu Asp Asp Gln Ala Leu Gly Pro Glu Leu Thr Ala 
                565                 570                 575     


Pro Ala Pro Glu Pro Pro Ala Glu Glu Pro Arg Leu Glu Pro Ala Gly 
            580                 585                 590         


Pro Ala Cys Pro Glu Gly Gly Arg Ala Glu Thr Gln Ala Glu Pro Pro 
        595                 600                 605             


Ser Val Gly Pro 
    610         


<210>  2392
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COIL__Homo_sapiens__NP_004636

<400>  2392

Met Ala Ala Ser Glu Thr Val Arg Leu Arg Leu Gln Phe Asp Tyr Pro 
1               5                   10                  15      


Pro Pro Ala Thr Pro His Cys Thr Ala Phe Trp Leu Leu Val Asp Leu 
            20                  25                  30          


Asn Arg Cys Arg Val Val Thr Asp Leu Ile Ser Leu Ile Arg Gln Arg 
        35                  40                  45              


Phe Gly Phe Ser Ser Gly Ala Phe Leu Gly Leu Tyr Leu Glu Gly Gly 
    50                  55                  60                  


Leu Leu Pro Pro Ala Glu Ser Ala Arg Leu Val Arg Asp Asn Asp Cys 
65                  70                  75                  80  


Leu Arg Val Lys Leu Glu Glu Arg Gly Val Ala Glu Asn Ser Val Val 
                85                  90                  95      


Ile Ser Asn Gly Asp Ile Asn Leu Ser Leu Arg Lys Ala Lys Lys Arg 
            100                 105                 110         


Ala Phe Gln Leu Glu Glu Gly Glu Glu Thr Glu Pro Asp Cys Lys Tyr 
        115                 120                 125             


Ser Lys Lys His Trp Lys Ser Arg Glu Asn Asn Asn Asn Asn Glu Lys 
    130                 135                 140                 


Val Leu Asp Leu Glu Pro Lys Ala Val Thr Asp Gln Thr Val Ser Lys 
145                 150                 155                 160 


Lys Asn Lys Arg Lys Asn Lys Ala Thr Cys Gly Thr Val Gly Asp Asp 
                165                 170                 175     


Asn Glu Glu Ala Lys Arg Lys Ser Pro Lys Lys Lys Glu Lys Cys Glu 
            180                 185                 190         


Tyr Lys Lys Lys Ala Lys Asn Pro Lys Ser Pro Lys Val Gln Ala Val 
        195                 200                 205             


Lys Asp Trp Ala Asn Gln Arg Cys Ser Ser Pro Lys Gly Ser Ala Arg 
    210                 215                 220                 


Asn Ser Leu Val Lys Ala Lys Arg Lys Gly Ser Val Ser Val Cys Ser 
225                 230                 235                 240 


Lys Glu Ser Pro Ser Ser Ser Ser Glu Ser Glu Ser Cys Asp Glu Ser 
                245                 250                 255     


Ile Ser Asp Gly Pro Ser Lys Val Thr Leu Glu Ala Arg Asn Ser Ser 
            260                 265                 270         


Glu Lys Leu Pro Thr Glu Leu Ser Lys Glu Glu Pro Ser Thr Lys Asn 
        275                 280                 285             


Thr Thr Ala Asp Lys Leu Ala Ile Lys Leu Gly Phe Ser Leu Thr Pro 
    290                 295                 300                 


Ser Lys Gly Lys Thr Ser Gly Thr Thr Ser Ser Ser Ser Asp Ser Ser 
305                 310                 315                 320 


Ala Glu Ser Asp Asp Gln Cys Leu Met Ser Ser Ser Thr Pro Glu Cys 
                325                 330                 335     


Ala Ala Gly Phe Leu Lys Thr Val Gly Leu Phe Ala Gly Arg Gly Arg 
            340                 345                 350         


Pro Gly Pro Gly Leu Ser Ser Gln Thr Ala Gly Ala Ala Gly Trp Arg 
        355                 360                 365             


Arg Ser Gly Ser Asn Gly Gly Gly Gln Ala Pro Gly Ala Ser Pro Ser 
    370                 375                 380                 


Val Ser Leu Pro Ala Ser Leu Gly Arg Gly Trp Gly Arg Glu Glu Asn 
385                 390                 395                 400 


Leu Phe Ser Trp Lys Gly Ala Lys Gly Arg Gly Met Arg Gly Arg Gly 
                405                 410                 415     


Arg Gly Arg Gly His Pro Val Ser Cys Val Val Asn Arg Ser Thr Asp 
            420                 425                 430         


Asn Gln Arg Gln Gln Gln Leu Asn Asp Val Val Lys Asn Ser Ser Thr 
        435                 440                 445             


Ile Ile Gln Asn Pro Val Glu Thr Pro Lys Lys Asp Tyr Ser Leu Leu 
    450                 455                 460                 


Pro Leu Leu Ala Ala Ala Pro Gln Val Gly Glu Lys Ile Ala Phe Lys 
465                 470                 475                 480 


Leu Leu Glu Leu Thr Ser Ser Tyr Ser Pro Asp Val Ser Asp Tyr Lys 
                485                 490                 495     


Glu Gly Arg Ile Leu Ser His Asn Pro Glu Thr Gln Gln Val Asp Ile 
            500                 505                 510         


Glu Ile Leu Ser Ser Leu Pro Ala Leu Arg Glu Pro Gly Lys Phe Asp 
        515                 520                 525             


Leu Val Tyr His Asn Glu Asn Gly Ala Glu Val Val Glu Tyr Ala Val 
    530                 535                 540                 


Thr Gln Glu Ser Lys Ile Thr Val Phe Trp Lys Glu Leu Ile Asp Pro 
545                 550                 555                 560 


Arg Leu Ile Ile Glu Ser Pro Ser Asn Thr Ser Ser Thr Glu Pro Ala 
                565                 570                 575     


<210>  2393
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL10A1__Homo_sapiens__XP_011533735

<400>  2393

Met Leu Pro Gln Ile Pro Phe Leu Leu Leu Val Ser Leu Asn Leu Val 
1               5                   10                  15      


His Gly Val Phe Tyr Ala Glu Arg Tyr Gln Met Pro Thr Gly Ile Lys 
            20                  25                  30          


Gly Pro Leu Pro Asn Thr Lys Thr Gln Phe Phe Ile Pro Tyr Thr Ile 
        35                  40                  45              


Lys Ser Lys Gly Ile Ala Val Arg Gly Glu Gln Gly Thr Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Ala Gly Pro Arg Gly His Pro Gly Pro Ser Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Pro Gly Tyr Gly Ser Pro Gly Leu Gln Gly Glu Pro Gly Leu 
                85                  90                  95      


Pro Gly Pro Pro Gly Pro Ser Ala Val Gly Lys Pro Gly Val Pro Gly 
            100                 105                 110         


Leu Pro Gly Lys Pro Gly Glu Arg Gly Pro Tyr Gly Pro Lys Gly Asp 
        115                 120                 125             


Val Gly Pro Ala Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Gly Ile Pro Gly Pro Ala Gly Ile Ser Val Pro Gly Lys Pro Gly Gln 
145                 150                 155                 160 


Gln Gly Pro Thr Gly Ala Pro Gly Pro Arg Gly Phe Pro Gly Glu Lys 
                165                 170                 175     


Gly Ala Pro Gly Val Pro Gly Met Asn Gly Gln Lys Gly Glu Met Gly 
            180                 185                 190         


Tyr Gly Ala Pro Gly Arg Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln 
        195                 200                 205             


Gly Pro Thr Gly Pro Ser Gly Pro Pro Gly Val Gly Lys Arg Gly Glu 
    210                 215                 220                 


Asn Gly Val Pro Gly Gln Pro Gly Ile Lys Gly Asp Arg Gly Phe Pro 
225                 230                 235                 240 


Gly Glu Met Gly Pro Ile Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
                245                 250                 255     


Glu Arg Gly Pro Glu Gly Ile Gly Lys Pro Gly Ala Ala Gly Ala Pro 
            260                 265                 270         


Gly Gln Pro Gly Ile Pro Gly Thr Lys Gly Leu Pro Gly Ala Pro Gly 
        275                 280                 285             


Ile Ala Gly Pro Pro Gly Pro Pro Gly Phe Gly Lys Pro Gly Leu Pro 
    290                 295                 300                 


Gly Leu Lys Gly Glu Arg Gly Pro Ala Gly Leu Pro Gly Gly Pro Gly 
305                 310                 315                 320 


Ala Lys Gly Glu Gln Gly Pro Ala Gly Leu Pro Gly Lys Pro Gly Leu 
                325                 330                 335     


Thr Gly Pro Pro Gly Asn Met Gly Pro Gln Gly Pro Lys Gly Ile Pro 
            340                 345                 350         


Gly Ser His Gly Leu Pro Gly Pro Lys Gly Glu Thr Gly Pro Ala Gly 
        355                 360                 365             


Pro Ala Gly Tyr Pro Gly Ala Lys Gly Glu Arg Gly Ser Pro Gly Ser 
    370                 375                 380                 


Asp Gly Lys Pro Gly Tyr Pro Gly Lys Pro Gly Leu Asp Gly Pro Lys 
385                 390                 395                 400 


Gly Asn Pro Gly Leu Pro Gly Pro Lys Gly Asp Pro Gly Val Gly Gly 
                405                 410                 415     


Pro Pro Gly Leu Pro Gly Pro Val Gly Pro Ala Gly Ala Lys Gly Met 
            420                 425                 430         


Pro Gly His Asn Gly Glu Ala Gly Pro Arg Gly Ala Pro Gly Ile Pro 
        435                 440                 445             


Gly Thr Arg Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Phe Pro Gly 
    450                 455                 460                 


Ser Lys Gly Asp Pro Gly Ser Pro Gly Pro Pro Gly Pro Ala Gly Ile 
465                 470                 475                 480 


Ala Thr Lys Gly Leu Asn Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Arg Gly His Ser Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro 
            500                 505                 510         


Pro Gly Pro Pro Gly Gln Ala Val Met Pro Glu Gly Phe Ile Lys Ala 
        515                 520                 525             


Gly Gln Arg Pro Ser Leu Ser Gly Thr Pro Leu Val Ser Ala Asn Gln 
    530                 535                 540                 


Gly Val Thr Gly Met Pro Val Ser Ala Phe Thr Val Ile Leu Ser Lys 
545                 550                 555                 560 


Ala Tyr Pro Ala Ile Gly Thr Pro Ile Pro Phe Asp Lys Ile Leu Tyr 
                565                 570                 575     


Asn Arg Gln Gln His Tyr Asp Pro Arg Thr Gly Ile Phe Thr Cys Gln 
            580                 585                 590         


Ile Pro Gly Ile Tyr Tyr Phe Ser Tyr His Val His Val Lys Gly Thr 
        595                 600                 605             


His Val Trp Val Gly Leu Tyr Lys Asn Gly Thr Pro Val Met Tyr Thr 
    610                 615                 620                 


Tyr Asp Glu Tyr Thr Lys Gly Tyr Leu Asp Gln Ala Ser Gly Ser Ala 
625                 630                 635                 640 


Ile Ile Asp Leu Thr Glu Asn Asp Gln Val Trp Leu Gln Leu Pro Asn 
                645                 650                 655     


Ala Glu Ser Asn Gly Leu Tyr Ser Ser Glu Tyr Val His Ser Ser Phe 
            660                 665                 670         


Ser Gly Phe Leu Val Ala Pro Met 
        675                 680 


<210>  2394
<211>  1464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL11A1__Homo_sapiens__XP_011539021

<400>  2394

Met Glu Pro Trp Ser Ser Arg Trp Lys Thr Lys Arg Trp Leu Trp Asp 
1               5                   10                  15      


Phe Thr Val Thr Thr Leu Ala Leu Thr Phe Leu Phe Gln Ala Arg Glu 
            20                  25                  30          


Val Arg Gly Ala Ala Pro Val Asp Val Leu Lys Ala Leu Asp Phe His 
        35                  40                  45              


Asn Ser Pro Glu Gly Ile Ser Lys Thr Thr Gly Phe Cys Thr Asn Arg 
    50                  55                  60                  


Lys Asn Ser Lys Gly Ser Asp Thr Ala Tyr Arg Val Ser Lys Gln Ala 
65                  70                  75                  80  


Gln Leu Ser Ala Pro Thr Lys Gln Leu Phe Pro Gly Gly Thr Phe Pro 
                85                  90                  95      


Glu Asp Phe Ser Ile Leu Phe Thr Val Lys Pro Lys Lys Gly Ile Gln 
            100                 105                 110         


Ser Phe Leu Leu Ser Ile Tyr Asn Glu His Gly Ile Gln Gln Ile Gly 
        115                 120                 125             


Val Glu Val Gly Arg Ser Pro Val Phe Leu Phe Glu Asp His Thr Gly 
    130                 135                 140                 


Lys Pro Ala Pro Glu Asp Tyr Pro Leu Phe Arg Thr Val Asn Ile Ala 
145                 150                 155                 160 


Asp Gly Lys Trp His Arg Val Ala Ile Ser Val Glu Lys Lys Thr Val 
                165                 170                 175     


Thr Met Ile Val Asp Cys Lys Lys Lys Thr Thr Lys Pro Leu Asp Arg 
            180                 185                 190         


Ser Glu Arg Ala Ile Val Asp Thr Asn Gly Ile Thr Val Phe Gly Thr 
        195                 200                 205             


Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Phe Leu 
    210                 215                 220                 


Ile Thr Gly Asp Pro Lys Ala Ala Tyr Asp Tyr Cys Glu His Tyr Ser 
225                 230                 235                 240 


Pro Asp Cys Asp Ser Ser Ala Pro Lys Ala Ala Gln Ala Gln Glu Pro 
                245                 250                 255     


Gln Ile Asp Glu Tyr Ala Pro Glu Asp Ile Ile Glu Tyr Asp Tyr Glu 
            260                 265                 270         


Tyr Gly Glu Ala Glu Tyr Lys Glu Ala Glu Ser Val Thr Glu Gly Pro 
        275                 280                 285             


Thr Val Thr Glu Glu Thr Ile Ala Gln Thr Glu Ala Asn Ile Val Asp 
    290                 295                 300                 


Asp Phe Gln Glu Tyr Asn Tyr Gly Thr Met Glu Ser Tyr Gln Thr Glu 
305                 310                 315                 320 


Ala Pro Arg His Val Ser Gly Thr Asn Glu Pro Asn Pro Val Glu Glu 
                325                 330                 335     


Ile Phe Thr Glu Glu Tyr Leu Thr Gly Glu Asp Tyr Asp Ser Gln Arg 
            340                 345                 350         


Lys Asn Ser Glu Asp Thr Leu Tyr Glu Asn Lys Glu Ile Asp Gly Arg 
        355                 360                 365             


Asp Ser Asp Leu Leu Val Asp Gly Asp Leu Gly Glu Tyr Asp Phe Tyr 
    370                 375                 380                 


Glu Tyr Lys Glu Tyr Glu Asp Lys Pro Thr Ser Pro Pro Asn Glu Glu 
385                 390                 395                 400 


Phe Gly Pro Gly Val Pro Ala Glu Thr Asp Ile Thr Glu Thr Ser Ile 
                405                 410                 415     


Asn Gly His Gly Ala Tyr Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala 
            420                 425                 430         


Val Val Glu Pro Gly Met Leu Val Glu Gly Pro Pro Gly Pro Ala Gly 
        435                 440                 445             


Pro Ala Gly Ile Met Gly Pro Pro Gly Leu Gln Gly Pro Thr Gly Pro 
    450                 455                 460                 


Pro Gly Asp Pro Gly Asp Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro 
465                 470                 475                 480 


Gly Ala Asp Gly Leu Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro 
                485                 490                 495     


Phe Arg Tyr Gly Gly Asp Gly Ser Lys Gly Pro Thr Ile Ser Ala Gln 
            500                 505                 510         


Glu Ala Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Ile Ala Leu Arg 
        515                 520                 525             


Gly Pro Pro Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly 
    530                 535                 540                 


Gly Pro Gly Ser Ser Gly Ala Lys Gly Glu Ser Gly Asp Pro Gly Pro 
545                 550                 555                 560 


Gln Gly Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Thr Gly Lys Pro 
                565                 570                 575     


Gly Lys Arg Gly Arg Pro Gly Ala Asp Gly Gly Arg Gly Met Pro Gly 
            580                 585                 590         


Glu Pro Gly Ala Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu 
        595                 600                 605             


Pro Gly Asp Lys Gly His Arg Gly Glu Arg Gly Pro Gln Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Asp Asp Gly Met Arg Gly Glu Asp Gly Glu Ile Gly 
625                 630                 635                 640 


Pro Arg Gly Leu Pro Gly Glu Ala Gly Pro Arg Gly Leu Leu Gly Pro 
                645                 650                 655     


Arg Gly Thr Pro Gly Ala Pro Gly Gln Pro Gly Met Ala Gly Val Asp 
            660                 665                 670         


Gly Pro Pro Gly Pro Lys Gly Asn Met Gly Pro Gln Gly Glu Pro Gly 
        675                 680                 685             


Pro Pro Gly Gln Gln Gly Asn Pro Gly Pro Gln Gly Leu Pro Gly Pro 
    690                 695                 700                 


Gln Gly Pro Ile Gly Pro Pro Gly Glu Lys Gly Pro Gln Gly Lys Pro 
705                 710                 715                 720 


Gly Leu Ala Gly Leu Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly 
                725                 730                 735     


Lys Glu Gly Gln Ser Gly Glu Lys Gly Ala Leu Gly Pro Pro Gly Pro 
            740                 745                 750         


Gln Gly Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp 
        755                 760                 765             


Gly Val Arg Gly Leu Lys Gly Ser Lys Gly Glu Lys Gly Glu Asp Gly 
    770                 775                 780                 


Phe Pro Gly Phe Lys Gly Asp Met Gly Leu Lys Gly Asp Arg Gly Glu 
785                 790                 795                 800 


Val Gly Gln Ile Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys 
                805                 810                 815     


Gly Arg Ala Gly Pro Thr Gly Asp Pro Gly Pro Ser Gly Gln Ala Gly 
            820                 825                 830         


Glu Lys Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg 
        835                 840                 845             


Gln Gly Pro Lys Gly Ser Thr Gly Phe Pro Gly Phe Pro Gly Ala Asn 
    850                 855                 860                 


Gly Glu Lys Gly Ala Arg Gly Val Ala Gly Lys Pro Gly Pro Arg Gly 
865                 870                 875                 880 


Gln Arg Gly Pro Thr Gly Pro Arg Gly Ser Arg Gly Ala Arg Gly Pro 
                885                 890                 895     


Thr Gly Lys Pro Gly Pro Lys Gly Thr Ser Gly Gly Asp Gly Pro Pro 
            900                 905                 910         


Gly Pro Pro Gly Glu Arg Gly Pro Gln Gly Pro Gln Gly Pro Val Gly 
        915                 920                 925             


Phe Pro Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu 
    930                 935                 940                 


Pro Gly His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr 
945                 950                 955                 960 


Gly Pro Pro Gly Pro Gly Gly Val Val Gly Pro Gln Gly Pro Thr Gly 
                965                 970                 975     


Glu Thr Gly Pro Ile Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro 
            980                 985                 990         


Pro Gly Glu Gln Gly Leu Pro Gly  Ala Ala Gly Lys Glu  Gly Ala Lys 
        995                 1000                 1005             


Gly Asp  Pro Gly Pro Gln Gly  Ile Ser Gly Lys Asp  Gly Pro Ala 
    1010                 1015                 1020             


Gly Leu  Arg Gly Phe Pro Gly  Glu Arg Gly Leu Pro  Gly Ala Gln 
    1025                 1030                 1035             


Gly Ala  Pro Gly Leu Lys Gly  Gly Glu Gly Pro Gln  Gly Pro Pro 
    1040                 1045                 1050             


Gly Pro  Val Gly Ser Pro Gly  Glu Arg Gly Ser Ala  Gly Thr Ala 
    1055                 1060                 1065             


Gly Pro  Ile Gly Leu Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1085                 1090                 1095             


Gly Pro  Ala Gly Arg Asp Gly  Val Gln Gly Pro Val  Gly Leu Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Pro Ala Gly  Ser Pro Gly Glu Asp  Gly Asp Lys 
    1115                 1120                 1125             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1130                 1135                 1140             


Gly Glu  Asn Gly Pro Pro Gly  Pro Pro Gly Leu Gln  Gly Pro Val 
    1145                 1150                 1155             


Gly Ala  Pro Gly Ile Ala Gly  Gly Asp Gly Glu Pro  Gly Pro Arg 
    1160                 1165                 1170             


Gly Gln  Gln Gly Met Phe Gly  Gln Lys Gly Asp Glu  Gly Ala Arg 
    1175                 1180                 1185             


Gly Phe  Pro Gly Pro Pro Gly  Pro Ile Gly Leu Gln  Gly Leu Pro 
    1190                 1195                 1200             


Gly Pro  Pro Gly Glu Lys Gly  Glu Asn Gly Asp Val  Gly Pro Met 
    1205                 1210                 1215             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Gln  Gly Pro Asn 
    1220                 1225                 1230             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Ser Val  Gly Ser Val 
    1235                 1240                 1245             


Gly Gly  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Asn Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Glu Ala Gly  Val Gly Gly Pro Lys  Gly Glu Arg 
    1265                 1270                 1275             


Gly Glu  Lys Gly Glu Ala Gly  Pro Pro Gly Ala Ala  Gly Pro Pro 
    1280                 1285                 1290             


Gly Ala  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Asn Pro 
    1295                 1300                 1305             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1310                 1315                 1320             


Gly Pro  Ala Gly Gln Asp Gly  Val Gly Gly Asp Lys  Gly Glu Asp 
    1325                 1330                 1335             


Gly Asp  Pro Gly Gln Pro Gly  Pro Pro Gly Pro Ser  Gly Glu Ala 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Ala Ala 
    1355                 1360                 1365             


Gly Ala  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1370                 1375                 1380             


Gly Ala  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Val  Gly Pro Gln 
    1385                 1390                 1395             


Gly Pro  Ala Gly Lys Pro Gly  Pro Glu Gly Leu Arg  Gly Ile Pro 
    1400                 1405                 1410             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ala Ala  Gly Gln Asp 
    1415                 1420                 1425             


Gly Pro  Pro Gly Pro Met Lys  Leu Pro Val Thr Thr  Tyr Cys Ile 
    1430                 1435                 1440             


Val Ser  Thr Gly Glu Ile Lys  Leu Pro Arg His Ser  Pro Phe Pro 
    1445                 1450                 1455             


His Leu  Leu Asn Thr Thr 
    1460                 


<210>  2395
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL11A2__Homo_sapiens__NP_001157243

<400>  2395

Met Glu Arg Cys Ser Arg Cys His Arg Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Val Leu Gly Leu Ser Ala Ala Pro Gly Trp Ala Gly Ala Pro Pro Val 
            20                  25                  30          


Asp Val Leu Arg Ala Leu Arg Phe Pro Ser Leu Pro Asp Gly Val Arg 
        35                  40                  45              


Arg Ala Lys Gly Ile Cys Pro Ala Asp Val Ala Tyr Arg Val Ala Arg 
    50                  55                  60                  


Pro Ala Gln Leu Ser Ala Pro Thr Arg Gln Leu Phe Pro Gly Gly Phe 
65                  70                  75                  80  


Pro Lys Asp Phe Ser Leu Leu Thr Val Val Arg Thr Arg Pro Gly Leu 
                85                  90                  95      


Gln Ala Pro Leu Leu Thr Leu Tyr Ser Ala Gln Gly Val Arg Gln Leu 
            100                 105                 110         


Gly Leu Glu Leu Gly Arg Pro Val Arg Phe Leu Tyr Glu Asp Gln Thr 
        115                 120                 125             


Gly Arg Pro Gln Pro Pro Ser Gln Pro Val Phe Arg Gly Leu Ser Leu 
    130                 135                 140                 


Ala Asp Gly Lys Trp His Arg Val Ala Val Ala Val Lys Gly Gln Ser 
145                 150                 155                 160 


Val Thr Leu Ile Val Asp Cys Lys Lys Arg Val Thr Arg Pro Leu Pro 
                165                 170                 175     


Arg Ser Ala Arg Pro Val Leu Asp Thr His Gly Val Ile Ile Phe Gly 
            180                 185                 190         


Ala Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Val Gln Glu Leu 
        195                 200                 205             


Ala Ile Val Pro Gly Val Gln Ala Ala Tyr Glu Ser Cys Glu Gln Lys 
    210                 215                 220                 


Glu Leu Glu Cys Glu Gly Gly Gln Arg Glu Arg Pro Gln Asn Gln Gln 
225                 230                 235                 240 


Pro His Arg Ala Gln Arg Ser Pro Gln Gln Gln Pro Ser Arg Leu His 
                245                 250                 255     


Arg Pro Gln Asn Gln Glu Pro Gln Ser Gln Val Arg Glu Leu Gly Glu 
            260                 265                 270         


Pro Pro Ser Ala Ala His Pro Arg Glu Gly Arg His Pro Gly Ile Ser 
        275                 280                 285             


Pro Pro 
    290 


<210>  2396
<211>  3063
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL12A1__Homo_sapiens__NP_004361

<400>  2396

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Val His Ile Val Val  Thr Ser Lys 
    2645                 2650                 2655             


Ser Val  Lys Ile Tyr Ile Asp  Cys Tyr Glu Ile Ile  Glu Lys Asp 
    2660                 2665                 2670             


Ile Lys  Glu Ala Gly Asn Ile  Thr Thr Asp Gly Tyr  Glu Ile Leu 
    2675                 2680                 2685             


Gly Lys  Leu Leu Lys Gly Glu  Arg Lys Ser Ala Ala  Phe Gln Ile 
    2690                 2695                 2700             


Gln Ser  Phe Asp Ile Val Cys  Ser Pro Val Trp Thr  Ser Arg Asp 
    2705                 2710                 2715             


Arg Cys  Cys Asp Ile Pro Ser  Arg Arg Asp Glu Gly  Lys Cys Pro 
    2720                 2725                 2730             


Ala Phe  Pro Asn Ser Cys Thr  Cys Thr Gln Asp Ser  Val Gly Pro 
    2735                 2740                 2745             


Pro Gly  Pro Pro Gly Pro Ala  Gly Gly Pro Gly Ala  Lys Gly Pro 
    2750                 2755                 2760             


Arg Gly  Glu Arg Gly Ile Ser  Gly Ala Ile Gly Pro  Pro Gly Pro 
    2765                 2770                 2775             


Arg Gly  Asp Ile Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Pro 
    2780                 2785                 2790             


Gln Gly  Pro Asn Gly Leu Ser  Ile Pro Gly Glu Gln  Gly Arg Gln 
    2795                 2800                 2805             


Gly Met  Lys Gly Asp Ala Gly  Glu Pro Gly Leu Pro  Gly Arg Thr 
    2810                 2815                 2820             


Gly Thr  Pro Gly Leu Pro Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    2825                 2830                 2835             


Gly Asp  Arg Gly Phe Thr Gly  Lys Asp Gly Ala Met  Gly Pro Arg 
    2840                 2845                 2850             


Gly Pro  Pro Gly Pro Pro Gly  Ser Pro Gly Ser Pro  Gly Val Thr 
    2855                 2860                 2865             


Gly Pro  Ser Gly Lys Pro Gly  Lys Pro Gly Asp His  Gly Arg Pro 
    2870                 2875                 2880             


Gly Pro  Ser Gly Leu Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ile 
    2885                 2890                 2895             


Ala Ser  Gln Asn Met Met Arg  Ala Val Ala Arg Gln  Val Cys Glu 
    2900                 2905                 2910             


Gln Leu  Ile Ser Gly Gln Met  Asn Arg Phe Asn Gln  Met Leu Asn 
    2915                 2920                 2925             


Gln Ile  Pro Asn Asp Tyr Gln  Ser Ser Arg Asn Gln  Pro Gly Pro 
    2930                 2935                 2940             


Pro Gly  Pro Pro Gly Pro Pro  Gly Ser Ala Gly Ala  Arg Gly Glu 
    2945                 2950                 2955             


Pro Gly  Pro Gly Gly Arg Pro  Gly Phe Pro Gly Thr  Pro Gly Met 
    2960                 2965                 2970             


Gln Gly  Pro Pro Gly Glu Arg  Gly Leu Pro Gly Glu  Lys Gly Glu 
    2975                 2980                 2985             


Arg Gly  Thr Gly Ser Ser Gly  Pro Arg Gly Leu Pro  Gly Pro Pro 
    2990                 2995                 3000             


Gly Pro  Gln Gly Glu Ser Arg  Thr Gly Pro Pro Gly  Ser Thr Gly 
    3005                 3010                 3015             


Ser Arg  Gly Pro Pro Gly Pro  Pro Gly Arg Pro Gly  Asn Ser Gly 
    3020                 3025                 3030             


Ile Arg  Gly Pro Pro Gly Pro  Pro Gly Tyr Cys Asp  Ser Ser Gln 
    3035                 3040                 3045             


Cys Ala  Ser Ile Pro Tyr Asn  Gly Gln Gly Tyr Pro  Gly Ser Gly 
    3050                 3055                 3060             


<210>  2397
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL13A1__Homo_sapiens__NP_001123575

<400>  2397

Met Val Ala Glu Arg Thr His Lys Ala Ala Ala Thr Gly Ala Arg Gly 
1               5                   10                  15      


Pro Gly Glu Leu Gly Ala Pro Gly Thr Val Ala Leu Val Ala Ala Arg 
            20                  25                  30          


Ala Glu Arg Gly Ala Arg Leu Pro Ser Pro Gly Ser Cys Gly Leu Leu 
        35                  40                  45              


Thr Leu Ala Leu Cys Ser Leu Ala Leu Ser Leu Leu Ala His Phe Arg 
    50                  55                  60                  


Thr Ala Glu Leu Gln Ala Arg Val Leu Arg Leu Glu Ala Glu Arg Gly 
65                  70                  75                  80  


Glu Gln Gln Met Glu Thr Ala Ile Leu Gly Arg Val Asn Gln Leu Leu 
                85                  90                  95      


Asp Glu Lys Trp Lys Leu His Ser Arg Arg Arg Arg Glu Ala Pro Lys 
            100                 105                 110         


Thr Ser Pro Gly Cys Asn Cys Pro Pro Gly Pro Pro Gly Pro Thr Gly 
        115                 120                 125             


Arg Pro Gly Leu Pro Gly Asp Lys Gly Ala Ile Gly Met Pro Gly Arg 
    130                 135                 140                 


Val Gly Ser Pro Gly Asp Ala Gly Leu Ser Ile Ile Gly Pro Arg Gly 
145                 150                 155                 160 


Pro Pro Gly Gln Pro Gly Thr Arg Gly Phe Pro Gly Phe Pro Gly Pro 
                165                 170                 175     


Ile Gly Leu Asp Gly Lys Pro Gly His Pro Gly Pro Lys Gly Asp Met 
            180                 185                 190         


Gly Leu Thr Gly Pro Pro Gly Gln Pro Gly Pro Gln Gly Gln Lys Gly 
        195                 200                 205             


Glu Lys Gly Gln Cys Gly Glu Tyr Pro His Arg Glu Cys Leu Ser Ser 
    210                 215                 220                 


Met Pro Ala Ala Leu Arg Ser Ser Gln Ile Ile Ala Leu Lys Leu Leu 
225                 230                 235                 240 


Pro Leu Leu Asn Ser Val Arg Leu Ala Pro Pro Pro Val Ile Lys Arg 
                245                 250                 255     


Arg Thr Phe Gln Gly Glu Gln Ser Gln Ala Ser Ile Gln Gly Pro Pro 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Pro Leu Gly His Pro Gly 
        275                 280                 285             


Leu Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro 
    290                 295                 300                 


Lys Gly Asp Pro Gly Ile Gln Gly Tyr His Gly Arg Lys Gly Glu Arg 
305                 310                 315                 320 


Gly Met Pro Gly Met Pro Gly Lys His Gly Ala Lys Gly Ala Pro Gly 
                325                 330                 335     


Ile Ala Val Ala Gly Met Lys Gly Glu Pro Gly Ile Pro Gly Thr Lys 
            340                 345                 350         


Gly Glu Lys Gly Ala Glu Gly Ser Pro Gly Leu Pro Gly Leu Leu Gly 
        355                 360                 365             


Gln Lys Gly Glu Lys Gly Asp Ala Gly Asn Ser Ile Gly Gly Gly Arg 
    370                 375                 380                 


Gly Glu Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly 
385                 390                 395                 400 


Glu Ala Gly Val Asp Gly Gln Val Gly Pro Pro Gly Gln Pro Gly Asp 
                405                 410                 415     


Lys Gly Glu Arg Gly Ala Ala Gly Glu Gln Gly Pro Asp Gly Pro Lys 
            420                 425                 430         


Gly Ser Lys Gly Glu Pro Gly Lys Gly Glu Met Val Asp Tyr Asn Gly 
        435                 440                 445             


Asn Ile Asn Glu Ala Leu Gln Glu Ile Arg Thr Leu Ala Leu Met Gly 
    450                 455                 460                 


Pro Pro Gly Leu Pro Gly Gln Ile Gly Pro Pro Gly Ala Pro Gly Ile 
465                 470                 475                 480 


Pro Gly Gln Lys Gly Glu Ile Gly Leu Pro Gly Pro Pro Gly His Asp 
                485                 490                 495     


Gly Glu Lys Gly Pro Arg Gly Lys Pro Gly Asp Met Gly Pro Pro Gly 
            500                 505                 510         


Pro Gln Gly Pro Pro Gly Lys Asp Gly Pro Pro Gly Val Lys Gly Glu 
        515                 520                 525             


Asn Gly His Pro Gly Ser Pro Gly Glu Lys Gly Glu Lys Gly Glu Thr 
    530                 535                 540                 


Gly Gln Ala Gly Ser Pro Gly Glu Lys Gly Glu Ala Gly Glu Lys Gly 
545                 550                 555                 560 


Asn Pro Gly Ala Glu Val Pro Gly Leu Pro Gly Pro Glu Gly Pro Pro 
                565                 570                 575     


Gly Pro Pro Gly Leu Gln Gly Val Pro Gly Pro Lys Gly Glu Ala Gly 
            580                 585                 590         


Leu Asp Gly Ala Lys Gly Glu Lys Gly Phe Gln Gly Glu Lys Gly Asp 
        595                 600                 605             


Arg Gly Pro Leu Gly Leu Pro Gly Ala Ser Gly Leu Asp Gly Arg Pro 
    610                 615                 620                 


Gly Pro Pro Gly Thr Pro Gly Pro Ile Gly Val Pro Gly Pro Ala Gly 
625                 630                 635                 640 


Pro Lys Gly Glu Arg Gly Ser Lys Gly Asp Pro Gly Met Thr Gly Pro 
                645                 650                 655     


Thr Gly Ala Ala Gly Leu Pro Gly Leu His Gly Pro Pro Gly Asp Lys 
            660                 665                 670         


Gly Asn Arg Gly Glu Arg Gly Lys Lys Gly Ser Arg Gly Pro Lys Gly 
        675                 680                 685             


Asp Lys Gly Asp Gln Gly Ala Pro Gly Leu Asp Ala Pro Cys Pro Leu 
    690                 695                 700                 


Gly Glu Asp Gly Leu Pro Val Gln Gly Cys Trp Asn Lys 
705                 710                 715         


<210>  2398
<211>  1780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL14A1__Homo_sapiens__XP_005251116

<400>  2398

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Phe Asn Phe Arg Leu 
                165                 170                 175     


Val Arg His Phe Leu Glu Asn Leu Val Thr Ala Phe Asp Val Gly Ser 
            180                 185                 190         


Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser Gly Asp Pro Arg Ile 
        195                 200                 205             


Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp Glu Val Ile Glu Ala 
    210                 215                 220                 


Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Leu Ala 
225                 230                 235                 240 


Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro Glu Ala Gly Ser Arg 
                245                 250                 255     


Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr Asp Gly Lys Ser Gln 
            260                 265                 270         


Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg Glu Ser Gly Val Glu 
        275                 280                 285             


Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val Asn Glu Leu Gln Glu 
    290                 295                 300                 


Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr Asn Val Ala Glu Phe 
305                 310                 315                 320 


Asp Leu Met His Thr Val Val Glu Ser Leu Thr Arg Thr Leu Cys Ser 
                325                 330                 335     


Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala Ser Ala His Ala Ile 
            340                 345                 350         


Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu Val Thr Ala Arg Ser 
        355                 360                 365             


Phe Met Val Asn Trp Thr His Ala Pro Gly Asn Val Glu Lys Tyr Arg 
    370                 375                 380                 


Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro Asp Glu Val Val Val 
385                 390                 395                 400 


Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn Leu Met Ser Leu Thr 
                405                 410                 415     


Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala His Thr Ala Ser Glu 
            420                 425                 430         


Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu Pro Met Ala Ser Asp 
        435                 440                 445             


Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met Arg Val Lys Trp Asp 
    450                 455                 460                 


Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu Tyr Ala Pro Leu Thr 
465                 470                 475                 480 


Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys Ile Gly Glu Thr His 
                485                 490                 495     


Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn Thr Glu Tyr Thr Val 
            500                 505                 510         


Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser Asp Pro Val Thr Gly 
        515                 520                 525             


Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg Asn Leu Arg Ile Ser 
    530                 535                 540                 


Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg 
545                 550                 555                 560 


Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn Ala Asp Gly Thr Glu 
                565                 570                 575     


Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr Phe Pro Leu Lys Gly 
            580                 585                 590         


Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile Phe Ser Ile Tyr Asp 
        595                 600                 605             


Glu Gly Gln Ser Glu Pro Leu Thr Gly Val Phe Thr Thr Glu Glu Val 
    610                 615                 620                 


Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val Thr Thr Asp Ser Phe 
625                 630                 635                 640 


Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu Gly Leu His Lys Leu 
                645                 650                 655     


Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu Glu Val Val Leu Lys 
            660                 665                 670         


Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu Glu Pro Gly Thr Glu 
        675                 680                 685             


Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp Gly Ser Glu Ser Glu 
    690                 695                 700                 


Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser Phe Trp Thr Glu Pro 
705                 710                 715                 720 


Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr Ser Val Phe Gln Thr 
                725                 730                 735     


Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr Thr Ser Ser Leu Arg 
            740                 745                 750         


Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln Gln Phe Arg Val Thr 
        755                 760                 765             


Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu Val Ile Gly Thr Val 
    770                 775                 780                 


Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu Lys Pro Leu Leu Pro 
785                 790                 795                 800 


Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile Tyr Thr Asp Gly Glu 
                805                 810                 815     


Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu Pro Ser Ser Gly Pro 
            820                 825                 830         


Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn Arg Leu Arg Ile Thr 
        835                 840                 845             


Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr Arg Ile Val Tyr Lys 
    850                 855                 860                 


Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr Phe Val Gly Ala Asp 
865                 870                 875                 880 


Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser Gly Met Asp Tyr Asn 
                885                 890                 895     


Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe Ser Asp Ala Leu Thr 
            900                 905                 910         


Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr Asn Leu Gln Ala Lys 
        915                 920                 925             


His Val Glu Met Thr Ser Leu Cys Ala His Trp Gln Val His Arg His 
    930                 935                 940                 


Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu Gln Asp Arg Gln Lys 
945                 950                 955                 960 


Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg His Cys Phe Tyr Gly 
                965                 970                 975     


Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val Tyr Thr Lys Leu Gln 
            980                 985                 990         


Glu Ile Glu Gly Pro Ser Val Ser  Ile Met Glu Lys Thr  Gln Ser Leu 
        995                 1000                 1005             


Pro Thr  Arg Pro Pro Thr Phe  Pro Pro Thr Ile Pro  Pro Ala Lys 
    1010                 1015                 1020             


Glu Val  Cys Lys Ala Ala Lys  Ala Asp Leu Val Phe  Met Val Asp 
    1025                 1030                 1035             


Gly Ser  Trp Ser Ile Gly Asp  Glu Asn Phe Asn Lys  Ile Ile Ser 
    1040                 1045                 1050             


Phe Leu  Tyr Ser Thr Val Gly  Ala Leu Asn Lys Ile  Gly Thr Asp 
    1055                 1060                 1065             


Gly Thr  Gln Val Ala Met Val  Gln Phe Thr Asp Asp  Pro Arg Thr 
    1070                 1075                 1080             


Glu Phe  Lys Leu Asn Ala Tyr  Lys Thr Lys Glu Thr  Leu Leu Asp 
    1085                 1090                 1095             


Ala Ile  Lys His Ile Ser Tyr  Lys Gly Gly Asn Thr  Lys Thr Gly 
    1100                 1105                 1110             


Lys Ala  Ile Lys Tyr Val Arg  Asp Thr Leu Phe Thr  Ala Glu Ser 
    1115                 1120                 1125             


Gly Thr  Arg Arg Gly Ile Pro  Lys Val Ile Val Val  Ile Thr Asp 
    1130                 1135                 1140             


Gly Arg  Ser Gln Asp Asp Val  Asn Lys Ile Ser Arg  Glu Met Gln 
    1145                 1150                 1155             


Leu Asp  Gly Tyr Ser Ile Phe  Ala Ile Gly Val Ala  Asp Ala Asp 
    1160                 1165                 1170             


Tyr Ser  Glu Leu Val Ser Ile  Gly Ser Lys Pro Ser  Ala Arg His 
    1175                 1180                 1185             


Val Phe  Phe Val Asp Asp Phe  Asp Ala Phe Lys Lys  Ile Glu Asp 
    1190                 1195                 1200             


Glu Leu  Ile Thr Phe Val Cys  Glu Thr Ala Ser Ala  Thr Cys Pro 
    1205                 1210                 1215             


Val Val  His Lys Asp Gly Ile  Asp Leu Ala Gly Phe  Lys Met Met 
    1220                 1225                 1230             


Glu Met  Phe Gly Leu Val Glu  Lys Asp Phe Ser Ser  Val Glu Gly 
    1235                 1240                 1245             


Val Ser  Met Glu Pro Gly Thr  Phe Asn Val Phe Pro  Cys Tyr Gln 
    1250                 1255                 1260             


Leu His  Lys Asp Ala Leu Val  Ser Gln Pro Thr Arg  Tyr Leu His 
    1265                 1270                 1275             


Pro Glu  Gly Leu Pro Ser Asp  Tyr Thr Ile Ser Phe  Leu Phe Arg 
    1280                 1285                 1290             


Ile Leu  Pro Asp Thr Pro Gln  Glu Pro Phe Ala Leu  Trp Glu Ile 
    1295                 1300                 1305             


Leu Asn  Lys Asn Ser Asp Pro  Leu Val Gly Val Ile  Leu Asp Asn 
    1310                 1315                 1320             


Gly Gly  Lys Thr Leu Thr Tyr  Phe Asn Tyr Asp Gln  Ser Gly Asp 
    1325                 1330                 1335             


Phe Gln  Thr Val Thr Phe Glu  Gly Pro Glu Ile Arg  Lys Ile Phe 
    1340                 1345                 1350             


Tyr Gly  Ser Phe His Lys Leu  His Ile Val Val Ser  Glu Thr Leu 
    1355                 1360                 1365             


Val Lys  Val Val Ile Asp Cys  Lys Gln Val Gly Glu  Lys Ala Met 
    1370                 1375                 1380             


Asn Ala  Ser Ala Asn Ile Thr  Ser Asp Gly Val Glu  Val Leu Gly 
    1385                 1390                 1395             


Lys Met  Val Arg Ser Arg Gly  Pro Gly Gly Asn Ser  Ala Pro Phe 
    1400                 1405                 1410             


Gln Leu  Gln Met Phe Asp Ile  Val Cys Ser Thr Ser  Trp Ala Asn 
    1415                 1420                 1425             


Thr Asp  Lys Cys Cys Glu Leu  Pro Gly Leu Arg Asp  Asp Glu Ser 
    1430                 1435                 1440             


Cys Pro  Asp Leu Pro His Ser  Cys Ser Cys Ser Glu  Thr Asn Glu 
    1445                 1450                 1455             


Val Ala  Leu Gly Pro Ala Gly  Pro Pro Gly Gly Pro  Gly Leu Arg 
    1460                 1465                 1470             


Gly Pro  Lys Gly Gln Gln Gly  Glu Pro Gly Pro Lys  Gly Pro Asp 
    1475                 1480                 1485             


Gly Pro  Arg Gly Glu Ile Gly  Leu Pro Gly Pro Gln  Gly Pro Pro 
    1490                 1495                 1500             


Gly Pro  Gln Gly Pro Ser Gly  Leu Ser Ile Gln Gly  Met Pro Gly 
    1505                 1510                 1515             


Met Pro  Gly Glu Lys Gly Glu  Lys Gly Asp Thr Gly  Leu Pro Gly 
    1520                 1525                 1530             


Pro Gln  Gly Ile Pro Gly Gly  Val Gly Ser Pro Gly  Arg Asp Gly 
    1535                 1540                 1545             


Ser Pro  Gly Gln Arg Gly Leu  Pro Gly Lys Asp Gly  Ser Ser Gly 
    1550                 1555                 1560             


Pro Pro  Gly Pro Pro Gly Pro  Ile Gly Ile Pro Gly  Thr Pro Gly 
    1565                 1570                 1575             


Val Pro  Gly Ile Thr Gly Ser  Met Gly Pro Gln Gly  Ala Leu Gly 
    1580                 1585                 1590             


Pro Pro  Gly Val Pro Gly Ala  Lys Gly Glu Arg Gly  Glu Arg Gly 
    1595                 1600                 1605             


Asp Leu  Gln Ser Gln Ala Met  Val Arg Ser Val Ala  Arg Gln Val 
    1610                 1615                 1620             


Cys Glu  Gln Leu Ile Gln Ser  His Met Ala Arg Tyr  Thr Ala Ile 
    1625                 1630                 1635             


Leu Asn  Gln Ile Pro Ser His  Ser Ser Ser Ile Arg  Thr Val Gln 
    1640                 1645                 1650             


Gly Pro  Pro Gly Glu Pro Gly  Arg Pro Gly Ser Pro  Gly Ala Pro 
    1655                 1660                 1665             


Gly Glu  Gln Gly Pro Pro Gly  Thr Pro Gly Phe Pro  Gly Asn Ala 
    1670                 1675                 1680             


Gly Val  Pro Gly Thr Pro Gly  Glu Arg Gly Leu Thr  Gly Ile Lys 
    1685                 1690                 1695             


Gly Glu  Lys Gly Asn Pro Gly  Val Gly Thr Gln Gly  Pro Arg Gly 
    1700                 1705                 1710             


Pro Pro  Gly Pro Ala Gly Pro  Ser Gly Glu Ser Arg  Pro Gly Ser 
    1715                 1720                 1725             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Arg Gly Pro  Pro Gly His 
    1730                 1735                 1740             


Leu Gly  Val Pro Gly Pro Gln  Gly Pro Ser Gly Gln  Pro Gly Tyr 
    1745                 1750                 1755             


Cys Asp  Pro Ser Ser Cys Ser  Ala Tyr Gly Val Arg  Asp Leu Ile 
    1760                 1765                 1770             


Pro Tyr  Asn Asp Tyr Gln His  
    1775                 1780 


<210>  2399
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL15A1__Homo_sapiens__XP_011516516

<400>  2399

Met Ala Pro Arg Arg Asn Asn Gly Gln Cys Trp Cys Leu Leu Met Leu 
1               5                   10                  15      


Leu Ser Val Ser Thr Pro Leu Pro Ala Val Thr Gln Thr Arg Gly Ala 
            20                  25                  30          


Thr Glu Thr Ala Ser Gln Gly His Leu Asp Leu Thr Gln Leu Ile Gly 
        35                  40                  45              


Val Pro Leu Pro Ser Ser Val Ser Phe Val Thr Gly Tyr Gly Gly Phe 
    50                  55                  60                  


Pro Ala Tyr Ser Phe Gly Pro Gly Ala Asn Val Gly Arg Pro Ala Arg 
65                  70                  75                  80  


Thr Leu Ile Pro Ser Thr Phe Phe Arg Asp Phe Ala Ile Ser Val Val 
                85                  90                  95      


Val Lys Pro Ser Ser Thr Arg Gly Gly Val Leu Phe Ala Ile Thr Asp 
            100                 105                 110         


Ala Phe Gln Lys Val Ile Tyr Leu Gly Leu Arg Leu Ser Gly Val Glu 
        115                 120                 125             


Asp Gly His Gln Arg Ile Ile Leu Tyr Tyr Thr Glu Pro Gly Ser His 
    130                 135                 140                 


Val Ser Gln Glu Ala Ala Ala Phe Ser Val Pro Val Met Thr His Arg 
145                 150                 155                 160 


Trp Asn Arg Phe Ala Met Ile Val Gln Gly Glu Glu Val Thr Leu Leu 
                165                 170                 175     


Val Asn Cys Glu Glu His Ser Arg Ile Pro Phe Gln Arg Ser Ser Gln 
            180                 185                 190         


Ala Leu Ala Phe Glu Ser Ser Ala Gly Ile Phe Met Gly Asn Ala Gly 
        195                 200                 205             


Ala Thr Gly Leu Glu Arg Phe Thr Gly Ser Leu Gln Gln Leu Thr Val 
    210                 215                 220                 


His Pro Asp Pro Arg Thr Pro Glu Glu Leu Cys Asp Pro Glu Glu Ser 
225                 230                 235                 240 


Ser Ala Ser Gly Glu Thr Ser Gly Leu Gln Glu Ala Asp Gly Val Ala 
                245                 250                 255     


Glu Ile Leu Glu Ala Val Thr Tyr Thr Gln Ala Ser Pro Lys Glu Ala 
            260                 265                 270         


Lys Val Glu Pro Ile Asn Thr Pro Pro Thr Pro Ser Ser Pro Phe Glu 
        275                 280                 285             


Asp Met Glu Leu Ser Gly Glu Pro Val Pro Glu Gly Thr Leu Glu Thr 
    290                 295                 300                 


Thr Asn Met Ser Ile Ile Gln His Ser Ser Pro Lys Gln Gly Ser Gly 
305                 310                 315                 320 


Glu Ile Leu Asn Asp Thr Leu Glu Gly Val His Ser Val Asp Gly Asp 
                325                 330                 335     


Pro Ile Thr Asp Ser Gly Ser Gly Ala Gly Ala Phe Leu Asp Ile Ala 
            340                 345                 350         


Glu Glu Lys Asn Leu Ala Ala Thr Ala Ala Gly Leu Ala Glu Val Pro 
        355                 360                 365             


Ile Ser Thr Ala Gly Glu Ala Glu Ala Ser Ser Val Pro Thr Gly Gly 
    370                 375                 380                 


Pro Thr Leu Ser Met Ser Thr Glu Asn Pro Glu Glu Gly Val Thr Pro 
385                 390                 395                 400 


Gly Pro Asp Asn Glu Glu Arg Leu Ala Ala Thr Ala Ala Gly Glu Ala 
                405                 410                 415     


Glu Ala Leu Ala Ser Met Pro Gly Glu Val Glu Ala Ser Gly Val Ala 
            420                 425                 430         


Pro Gly Glu Leu Asp Leu Ser Met Ser Ala Gln Ser Leu Gly Glu Glu 
        435                 440                 445             


Ala Thr Val Gly Pro Ser Ser Glu Asp Ser Leu Thr Thr Ala Ala Ala 
    450                 455                 460                 


Ala Thr Glu Val Ser Leu Ser Thr Phe Glu Asp Glu Glu Ala Ser Gly 
465                 470                 475                 480 


Val Pro Thr Asp Gly Leu Ala Pro Leu Thr Ala Thr Met Ala Pro Glu 
                485                 490                 495     


Arg Ala Val Thr Ser Gly Pro Gly Asp Glu Glu Asp Leu Ala Ala Ala 
            500                 505                 510         


Thr Thr Glu Glu Pro Leu Ile Thr Ala Gly Gly Glu Glu Ser Gly Ser 
        515                 520                 525             


Pro Pro Pro Asp Gly Pro Pro Leu Pro Leu Pro Thr Val Ala Pro Glu 
    530                 535                 540                 


Arg Trp Ile Thr Pro Ala Gln Arg Glu His Val Gly Met Lys Gly Gln 
545                 550                 555                 560 


Ala Gly Pro Lys Gly Glu Lys Gly Asp Ala Gly Glu Glu Leu Pro Gly 
                565                 570                 575     


Pro Pro Glu Pro Ser Gly Pro Val Gly Pro Thr Ala Gly Ala Glu Ala 
            580                 585                 590         


Glu Gly Ser Gly Leu Gly Trp Gly Ser Asp Val Gly Ser Gly Ser Gly 
        595                 600                 605             


Asp Leu Val Gly Ser Glu Gln Leu Leu Arg Gly Pro Pro Gly Pro Pro 
    610                 615                 620                 


Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Lys Pro Gly Thr Asp Val 
625                 630                 635                 640 


Phe Met Gly Pro Pro Gly Ser Pro Gly Glu Asp Gly Pro Ala Gly Glu 
                645                 650                 655     


Pro Gly Pro Pro Gly Pro Glu Gly Gln Pro Gly Val Asp Gly Ala Thr 
            660                 665                 670         


Gly Leu Pro Gly Met Lys Gly Glu Lys Gly Ala Arg Gly Pro Asn Gly 
        675                 680                 685             


Ser Val Gly Glu Lys Gly Asp Pro Gly Asn Arg Gly Leu Pro Gly Pro 
    690                 695                 700                 


Pro Gly Lys Lys Gly Gln Ala Gly Pro Pro Gly Val Met Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Cys Thr Met Gly 
                725                 730                 735     


Leu Gly Phe Glu Asp Thr Glu Gly Ser Gly Ser Thr Gln Leu Leu Asn 
            740                 745                 750         


Glu Pro Lys Leu Ser Arg Pro Thr Ala Ala Ile Gly Leu Lys Gly Glu 
        755                 760                 765             


Lys Gly Asp Arg Gly Pro Lys Gly Glu Arg Gly Met Asp Gly Ala Ser 
    770                 775                 780                 


Ile Val Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly His Ile Lys Val 
785                 790                 795                 800 


Leu Ser Asn Ser Leu Ile Asn Ile Thr His Gly Phe Met Asn Phe Ser 
                805                 810                 815     


Asp Ile Pro Glu Leu Val Gly Pro Pro Gly Pro Asp Gly Leu Pro Gly 
            820                 825                 830         


Leu Pro Gly Phe Pro Gly Pro Arg Gly Pro Lys Gly Asp Thr Gly Leu 
        835                 840                 845             


Pro Gly Phe Pro Gly Leu Lys Gly Glu Gln Gly Glu Lys Gly Glu Pro 
    850                 855                 860                 


Gly Ala Ile Leu Thr Glu Asp Ile Pro Leu Glu Arg Leu Met Gly Lys 
865                 870                 875                 880 


Lys Gly Glu Pro Gly Met His Gly Ala Pro Gly Pro Met Gly Pro Lys 
                885                 890                 895     


Gly Pro Pro Gly His Lys Gly Glu Phe Gly Leu Pro Gly Arg Pro Gly 
            900                 905                 910         


Arg Pro Gly Leu Asn Gly Leu Lys Gly Thr Lys Gly Asp Pro Gly Val 
        915                 920                 925             


Ile Met Gln Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
    930                 935                 940                 


Pro Pro Gly Ala Val Ile Asn Ile Lys Gly Ala Ile Phe Pro Ile Pro 
945                 950                 955                 960 


Val Arg Pro His Cys Lys Met Pro Val Asp Thr Ala His Pro Gly Ser 
                965                 970                 975     


Pro Glu Leu Ile Thr Phe His Gly Val Lys Gly Glu Lys Gly Ser Trp 
            980                 985                 990         


Gly Leu Pro Gly Ser Lys Gly Glu  Lys Gly Asp Gln Gly  Ala Gln Gly 
        995                 1000                 1005             


Pro Pro  Gly Pro Pro Leu Asp  Leu Ala Tyr Leu Arg  His Phe Leu 
    1010                 1015                 1020             


Asn Asn  Leu Lys Gly Glu Asn  Gly Asp Lys Gly Phe  Lys Gly Glu 
    1025                 1030                 1035             


Lys Gly  Glu Lys Gly Asp Ile  Asn Gly Ser Phe Leu  Met Ser Gly 
    1040                 1045                 1050             


Pro Pro  Gly Leu Pro Gly Asn  Pro Gly Pro Ala Gly  Gln Lys Gly 
    1055                 1060                 1065             


Glu Thr  Val Val Gly Pro Gln  Gly Pro Pro Gly Ala  Pro Gly Leu 
    1070                 1075                 1080             


Pro Gly  Pro Pro Gly Phe Gly  Arg Pro Gly Asp Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Ala Ile Leu  Gly Ala Ala 
    1100                 1105                 1110             


Val Ala  Leu Pro Gly Pro Pro  Gly Pro Pro Gly Gln  Pro Gly Leu 
    1115                 1120                 1125             


Pro Gly  Ser Arg Asn Leu Val  Thr Ala Phe Ser Asn  Met Asp Asp 
    1130                 1135                 1140             


Met Leu  Gln Lys Ala His Leu  Val Ile Glu Gly Thr  Phe Ile Tyr 
    1145                 1150                 1155             


Leu Arg  Asp Ser Thr Glu Phe  Phe Ile Arg Val Arg  Asp Gly Trp 
    1160                 1165                 1170             


Lys Lys  Leu Gln Leu Gly Glu  Leu Ile Pro Ile Pro  Ala Asp Ser 
    1175                 1180                 1185             


Pro Pro  Pro Pro Ala Leu Ser  Ser Asn Pro His Gln  Leu Leu Pro 
    1190                 1195                 1200             


Pro Pro  Asn Pro Ile Ser Ser  Ala Asn Tyr Glu Lys  Pro Ala Leu 
    1205                 1210                 1215             


His Leu  Ala Ala Leu Asn Met  Pro Phe Ser Gly Asp  Ile Arg Ala 
    1220                 1225                 1230             


Asp Phe  Gln Cys Phe Lys Gln  Ala Arg Ala Ala Gly  Leu Leu Ser 
    1235                 1240                 1245             


Thr Tyr  Arg Ala Phe Leu Ser  Ser His Leu Gln Asp  Leu Ser Thr 
    1250                 1255                 1260             


Ile Val  Arg Lys Ala Glu Arg  Tyr Ser Leu Pro Ile  Val Asn Leu 
    1265                 1270                 1275             


Lys Gly  Gln Val Leu Phe Asn  Asn Trp Asp Ser Ile  Phe Ser Gly 
    1280                 1285                 1290             


His Gly  Gly Gln Phe Asn Met  His Ile Pro Ile Tyr  Ser Phe Asp 
    1295                 1300                 1305             


Gly Arg  Asp Ile Met Thr Asp  Pro Ser Trp Pro Gln  Lys Val Ile 
    1310                 1315                 1320             


Trp His  Gly Ser Ser Pro His  Gly Val Arg Leu Val  Asp Asn Tyr 
    1325                 1330                 1335             


Cys Glu  Ala Trp Arg Thr Ala  Asp Thr Ala Val Thr  Gly Leu Ala 
    1340                 1345                 1350             


Ser Pro  Leu Ser Thr Gly Lys  Ile Leu Asp Gln Lys  Ala Tyr Ser 
    1355                 1360                 1365             


Cys Ala  Asn Arg Leu Ile Val  Leu Cys Ile Glu Asn  Ser Phe Met 
    1370                 1375                 1380             


Thr Asp  Ala Arg Lys 
    1385             


<210>  2400
<211>  1563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL16A1__Homo_sapiens__XP_011539026

<400>  2400

Met Trp Val Ser Trp Ala Pro Gly Leu Trp Leu Leu Gly Leu Trp Ala 
1               5                   10                  15      


Thr Phe Gly His Gly Ala Asn Thr Gly Ala Gln Cys Pro Pro Ser Gln 
            20                  25                  30          


Gln Glu Gly Leu Lys Leu Glu His Ser Ser Ser Leu Pro Ala Asn Val 
        35                  40                  45              


Thr Gly Phe Asn Leu Ile His Arg Leu Ser Leu Met Lys Thr Ser Ala 
    50                  55                  60                  


Ile Lys Lys Ile Arg Asn Pro Lys Gly Pro Leu Ile Leu Arg Leu Gly 
65                  70                  75                  80  


Ala Ala Pro Val Thr Gln Pro Thr Arg Arg Val Phe Pro Arg Gly Leu 
                85                  90                  95      


Pro Glu Glu Phe Ala Leu Val Leu Thr Leu Leu Leu Lys Lys His Thr 
            100                 105                 110         


His Gln Lys Thr Trp Tyr Leu Phe Gln Val Thr Asp Ala Asn Gly Tyr 
        115                 120                 125             


Pro Gln Ile Ser Leu Glu Val Asn Ser Gln Glu Arg Ser Leu Glu Leu 
    130                 135                 140                 


Arg Ala Gln Gly Gln Asp Gly Asp Phe Val Ser Cys Ile Phe Pro Val 
145                 150                 155                 160 


Pro Gln Leu Phe Asp Leu Arg Trp His Lys Leu Met Leu Ser Val Ala 
                165                 170                 175     


Gly Arg Val Ala Ser Val His Val Asp Cys Ser Ser Ala Ser Ser Gln 
            180                 185                 190         


Pro Leu Gly Pro Arg Arg Pro Met Arg Pro Val Gly His Val Phe Leu 
        195                 200                 205             


Gly Leu Asp Ala Glu Gln Gly Lys Pro Val Ser Phe Asp Leu Gln Gln 
    210                 215                 220                 


Val His Ile Tyr Cys Asp Pro Glu Leu Val Leu Glu Glu Gly Cys Cys 
225                 230                 235                 240 


Glu Ile Leu Pro Ala Gly Cys Pro Pro Glu Thr Ser Lys Ala Arg Arg 
                245                 250                 255     


Asp Thr Gln Ser Asn Glu Leu Ile Glu Ile Asn Pro Gln Ser Glu Gly 
            260                 265                 270         


Lys Val Tyr Thr Arg Cys Phe Cys Leu Glu Glu Pro Gln Asn Ser Glu 
        275                 280                 285             


Val Asp Ala Gln Leu Thr Gly Arg Ile Ser Gln Lys Ala Glu Arg Gly 
    290                 295                 300                 


Ala Lys Val His Gln Glu Thr Ala Ala Asp Glu Cys Pro Pro Cys Val 
305                 310                 315                 320 


His Gly Ala Arg Asp Ser Asn Val Thr Leu Ala Pro Ser Gly Pro Lys 
                325                 330                 335     


Gly Gly Lys Gly Glu Arg Gly Leu Pro Gly Pro Pro Gly Ser Lys Gly 
            340                 345                 350         


Glu Lys Gly Ala Arg Gly Asn Asp Cys Val Arg Ile Ser Pro Asp Ala 
        355                 360                 365             


Pro Leu Gln Cys Ala Glu Gly Pro Lys Gly Glu Lys Gly Glu Ser Gly 
    370                 375                 380                 


Ala Leu Gly Pro Ser Gly Leu Pro Gly Ser Thr Gly Glu Lys Gly Gln 
385                 390                 395                 400 


Lys Gly Glu Lys Gly Asp Gly Gly Ile Lys Gly Val Pro Gly Lys Pro 
                405                 410                 415     


Gly Arg Asp Gly Arg Pro Gly Glu Ile Cys Val Ile Gly Pro Lys Gly 
            420                 425                 430         


Gln Lys Gly Asp Pro Gly Phe Val Gly Pro Glu Gly Leu Ala Gly Glu 
        435                 440                 445             


Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Ile Gly Leu Pro Gly 
    450                 455                 460                 


Thr Pro Gly Asp Pro Gly Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Ile Pro Gly Lys Glu Gly Pro Gly Gly Lys Pro Gly Lys 
                485                 490                 495     


Pro Gly Val Lys Gly Glu Lys Gly Asp Pro Cys Glu Val Cys Pro Thr 
            500                 505                 510         


Leu Pro Glu Gly Phe Gln Asn Phe Val Gly Leu Pro Gly Lys Pro Gly 
        515                 520                 525             


Pro Lys Gly Glu Pro Gly Asp Pro Val Pro Ala Arg Gly Asp Pro Gly 
    530                 535                 540                 


Ile Gln Gly Ile Lys Gly Glu Lys Gly Glu Pro Cys Leu Ser Cys Ser 
545                 550                 555                 560 


Ser Val Val Gly Ala Gln His Leu Val Ser Ser Thr Gly Ala Ser Gly 
                565                 570                 575     


Asp Val Gly Ser Pro Gly Phe Gly Leu Pro Gly Leu Pro Gly Arg Ala 
            580                 585                 590         


Gly Val Pro Gly Leu Lys Gly Glu Lys Gly Asn Phe Gly Glu Ala Gly 
        595                 600                 605             


Pro Ala Gly Ser Pro Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Ile 
    610                 615                 620                 


Lys Gly Ala Lys Gly Glu Pro Cys Glu Pro Cys Pro Ala Leu Ser Asn 
625                 630                 635                 640 


Leu Gln Asp Gly Asp Val Arg Val Val Ala Leu Pro Gly Pro Ser Gly 
                645                 650                 655     


Glu Lys Gly Glu Pro Gly Pro Pro Gly Phe Gly Leu Pro Gly Lys Gln 
            660                 665                 670         


Gly Lys Ala Gly Glu Arg Gly Leu Lys Gly Gln Lys Gly Asp Ala Gly 
        675                 680                 685             


Asn Pro Gly Asp Pro Gly Thr Pro Gly Thr Thr Gly Arg Pro Gly Leu 
    690                 695                 700                 


Ser Gly Glu Pro Gly Val Gln Gly Pro Ala Gly Pro Lys Gly Glu Lys 
705                 710                 715                 720 


Gly Gln Pro Gly Leu Pro Gly Val Gln Gly Pro Pro Gly Leu Lys Gly 
                725                 730                 735     


Val Gln Gly Glu Pro Gly Pro Pro Gly Arg Gly Val Gln Gly Pro Gln 
            740                 745                 750         


Gly Glu Pro Gly Ala Pro Gly Leu Pro Gly Ile Gln Gly Leu Pro Gly 
        755                 760                 765             


Pro Arg Gly Pro Pro Gly Pro Thr Gly Glu Lys Gly Ala Gln Gly Ser 
    770                 775                 780                 


Pro Gly Val Lys Gly Ala Thr Gly Pro Val Gly Pro Pro Gly Ala Ser 
785                 790                 795                 800 


Val Ser Gly Pro Pro Gly Arg Asp Gly Gln Gln Gly Gln Thr Gly Leu 
                805                 810                 815     


Arg Gly Thr Pro Gly Glu Lys Gly Pro Arg Gly Glu Lys Gly Glu Pro 
            820                 825                 830         


Gly Glu Cys Ser Cys Pro Ser Gln Gly Asp Leu Ile Phe Ser Gly Met 
        835                 840                 845             


Pro Gly Ala Pro Gly Leu Trp Met Gly Ser Ser Trp Gln Pro Gly Pro 
    850                 855                 860                 


Gln Gly Pro Pro Gly Ile Pro Gly Pro Pro Gly Pro Pro Gly Val Pro 
865                 870                 875                 880 


Gly Leu Gln Gly Val Pro Gly Asn Asn Gly Leu Pro Gly Gln Pro Gly 
                885                 890                 895     


Leu Thr Ala Glu Leu Gly Ser Leu Pro Ile Glu Gln His Leu Leu Lys 
            900                 905                 910         


Ser Ile Cys Gly Asp Cys Val Gln Gly Gln Arg Ala His Pro Gly Tyr 
        915                 920                 925             


Leu Val Glu Lys Gly Glu Lys Gly Asp Gln Gly Ile Pro Gly Val Pro 
    930                 935                 940                 


Gly Leu Asp Asn Cys Ala Gln Cys Phe Leu Ser Leu Glu Arg Pro Arg 
945                 950                 955                 960 


Ala Glu Glu Ala Arg Gly Asp Asn Ser Glu Gly Asp Pro Gly Cys Val 
                965                 970                 975     


Gly Ser Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Gln Arg Gly 
            980                 985                 990         


Glu Glu Gly Pro Pro Gly Met Arg  Gly Ser Pro Gly Pro  Pro Gly Pro 
        995                 1000                 1005             


Ile Gly  Pro Pro Gly Phe Pro  Gly Ala Val Gly Ser  Pro Gly Leu 
    1010                 1015                 1020             


Pro Gly  Leu Gln Gly Glu Arg  Gly Leu Thr Gly Leu  Thr Gly Asp 
    1025                 1030                 1035             


Lys Gly  Glu Pro Gly Pro Pro  Gly Gln Pro Gly Tyr  Pro Gly Ala 
    1040                 1045                 1050             


Thr Gly  Pro Pro Gly Leu Pro  Gly Ile Lys Gly Glu  Arg Gly Tyr 
    1055                 1060                 1065             


Thr Gly  Ser Ala Gly Glu Lys  Gly Glu Pro Gly Pro  Pro Gly Ser 
    1070                 1075                 1080             


Glu Gly  Leu Pro Gly Pro Pro  Gly Pro Ala Gly Pro  Arg Gly Glu 
    1085                 1090                 1095             


Arg Gly  Pro Gln Gly Asn Ser  Gly Glu Lys Gly Asp  Gln Gly Phe 
    1100                 1105                 1110             


Gln Gly  Gln Pro Gly Phe Pro  Gly Pro Pro Gly Pro  Pro Gly Phe 
    1115                 1120                 1125             


Pro Gly  Lys Val Gly Ser Pro  Gly Pro Pro Gly Pro  Gln Ala Glu 
    1130                 1135                 1140             


Lys Gly  Ser Glu Gly Ile Arg  Gly Pro Ser Gly Leu  Pro Gly Ser 
    1145                 1150                 1155             


Pro Gly  Pro Pro Gly Pro Pro  Gly Ile Gln Gly Pro  Ala Gly Leu 
    1160                 1165                 1170             


Asp Gly  Leu Asp Gly Lys Asp  Gly Lys Pro Gly Leu  Arg Gly Asp 
    1175                 1180                 1185             


Pro Gly  Pro Ala Gly Pro Pro  Gly Leu Met Gly Pro  Pro Gly Phe 
    1190                 1195                 1200             


Lys Gly  Lys Thr Gly His Pro  Gly Leu Pro Gly Pro  Lys Gly Asp 
    1205                 1210                 1215             


Cys Gly  Lys Pro Gly Pro Pro  Gly Ser Thr Gly Arg  Pro Gly Ala 
    1220                 1225                 1230             


Glu Gly  Glu Pro Gly Ala Met  Gly Pro Gln Gly Arg  Pro Gly Pro 
    1235                 1240                 1245             


Pro Gly  His Val Gly Pro Pro  Gly Pro Pro Gly Gln  Pro Gly Pro 
    1250                 1255                 1260             


Ala Gly  Ile Ser Ala Val Gly  Leu Lys Gly Asp Arg  Gly Ala Thr 
    1265                 1270                 1275             


Gly Glu  Arg Gly Leu Ala Gly  Leu Pro Gly Gln Pro  Gly Pro Pro 
    1280                 1285                 1290             


Gly His  Pro Gly Pro Pro Gly  Glu Pro Gly Thr Asp  Gly Ala Ala 
    1295                 1300                 1305             


Gly Lys  Glu Gly Pro Pro Gly  Lys Gln Gly Phe Tyr  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Asp Pro Gly  Ala Ala Gly Gln Lys  Gly Gln Ala 
    1325                 1330                 1335             


Gly Glu  Lys Gly Arg Ala Gly  Met Pro Gly Gly Pro  Gly Lys Ser 
    1340                 1345                 1350             


Gly Ser  Met Gly Pro Val Gly  Pro Pro Gly Pro Ala  Gly Glu Arg 
    1355                 1360                 1365             


Gly His  Pro Gly Ala Pro Gly  Pro Ser Gly Ser Pro  Gly Leu Pro 
    1370                 1375                 1380             


Gly Val  Pro Gly Ser Met Gly  Asp Met Val Asn Tyr  Asp Glu Ile 
    1385                 1390                 1395             


Lys Arg  Phe Ile Arg Gln Glu  Ile Ile Lys Met Phe  Asp Glu Arg 
    1400                 1405                 1410             


Met Ala  Tyr Tyr Thr Ser Arg  Met Gln Phe Pro Met  Glu Met Ala 
    1415                 1420                 1425             


Ala Ala  Pro Gly Arg Pro Gly  Pro Pro Gly Lys Asp  Gly Ala Pro 
    1430                 1435                 1440             


Gly Arg  Pro Gly Ala Pro Gly  Ser Pro Gly Leu Pro  Gly Gln Ile 
    1445                 1450                 1455             


Gly Arg  Glu Gly Arg Gln Gly  Leu Pro Gly Val Arg  Gly Leu Pro 
    1460                 1465                 1470             


Gly Thr  Lys Gly Glu Lys Gly  Asp Ile Gly Ile Gly  Ile Ala Gly 
    1475                 1480                 1485             


Glu Asn  Gly Leu Pro Gly Pro  Pro Gly Pro Gln Gly  Pro Pro Gly 
    1490                 1495                 1500             


Tyr Gly  Lys Met Gly Ala Thr  Gly Pro Met Gly Gln  Gln Gly Ile 
    1505                 1510                 1515             


Pro Gly  Ile Pro Gly Pro Pro  Gly Pro Met Gly Gln  Pro Gly Lys 
    1520                 1525                 1530             


Ala Gly  His Cys Asn Pro Ser  Asp Cys Phe Gly Ala  Met Pro Met 
    1535                 1540                 1545             


Glu Gln  Gln Tyr Pro Pro Met  Lys Thr Met Lys Gly  Pro Phe Gly 
    1550                 1555                 1560             


<210>  2401
<211>  1497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL17A1__Homo_sapiens__NP_000485

<400>  2401

Met Asp Val Thr Lys Lys Asn Lys Arg Asp Gly Thr Glu Val Thr Glu 
1               5                   10                  15      


Arg Ile Val Thr Glu Thr Val Thr Thr Arg Leu Thr Ser Leu Pro Pro 
            20                  25                  30          


Lys Gly Gly Thr Ser Asn Gly Tyr Ala Lys Thr Ala Ser Leu Gly Gly 
        35                  40                  45              


Gly Ser Arg Leu Glu Lys Gln Ser Leu Thr His Gly Ser Ser Gly Tyr 
    50                  55                  60                  


Ile Asn Ser Thr Gly Ser Thr Arg Gly His Ala Ser Thr Ser Ser Tyr 
65                  70                  75                  80  


Arg Arg Ala His Ser Pro Ala Ser Thr Leu Pro Asn Ser Pro Gly Ser 
                85                  90                  95      


Thr Phe Glu Arg Lys Thr His Val Thr Arg His Ala Tyr Glu Gly Ser 
            100                 105                 110         


Ser Ser Gly Asn Ser Ser Pro Glu Tyr Pro Arg Lys Glu Phe Ala Ser 
        115                 120                 125             


Ser Ser Thr Arg Gly Arg Ser Gln Thr Arg Glu Ser Glu Ile Arg Val 
    130                 135                 140                 


Arg Leu Gln Ser Ala Ser Pro Ser Thr Arg Trp Thr Glu Leu Asp Asp 
145                 150                 155                 160 


Val Lys Arg Leu Leu Lys Gly Ser Arg Ser Ala Ser Val Ser Pro Thr 
                165                 170                 175     


Arg Asn Ser Ser Asn Thr Leu Pro Ile Pro Lys Lys Gly Thr Val Glu 
            180                 185                 190         


Thr Lys Ile Val Thr Ala Ser Ser Gln Ser Val Ser Gly Thr Tyr Asp 
        195                 200                 205             


Ala Thr Ile Leu Asp Ala Asn Leu Pro Ser His Val Trp Ser Ser Thr 
    210                 215                 220                 


Leu Pro Ala Gly Ser Ser Met Gly Thr Tyr His Asn Asn Met Thr Thr 
225                 230                 235                 240 


Gln Ser Ser Ser Leu Leu Asn Thr Asn Ala Tyr Ser Ala Gly Ser Val 
                245                 250                 255     


Phe Gly Val Pro Asn Asn Met Ala Ser Cys Ser Pro Thr Leu His Pro 
            260                 265                 270         


Gly Leu Ser Thr Ser Ser Ser Val Phe Gly Met Gln Asn Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Thr Thr Leu Ser His Gly Thr Thr Thr Thr Ser Thr Ala 
    290                 295                 300                 


Tyr Gly Val Lys Lys Asn Met Pro Gln Ser Pro Ala Ala Val Asn Thr 
305                 310                 315                 320 


Gly Val Ser Thr Ser Ala Ala Cys Thr Thr Ser Val Gln Ser Asp Asp 
                325                 330                 335     


Leu Leu His Lys Asp Cys Lys Phe Leu Ile Leu Glu Lys Asp Asn Thr 
            340                 345                 350         


Pro Ala Lys Lys Glu Met Glu Leu Leu Ile Met Thr Lys Asp Ser Gly 
        355                 360                 365             


Lys Val Phe Thr Ala Ser Pro Ala Ser Ile Ala Ala Thr Ser Phe Ser 
    370                 375                 380                 


Glu Asp Thr Leu Lys Lys Glu Lys Gln Ala Ala Tyr Asn Ala Asp Ser 
385                 390                 395                 400 


Gly Leu Lys Ala Glu Ala Asn Gly Asp Leu Lys Thr Val Ser Thr Lys 
                405                 410                 415     


Gly Lys Thr Thr Thr Ala Asp Ile His Ser Tyr Gly Ser Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Gly Val Gly Gly Ala Gly Gly Gly Pro 
        435                 440                 445             


Trp Gly Pro Ala Pro Ala Trp Cys Pro Cys Gly Ser Cys Cys Ser Trp 
    450                 455                 460                 


Trp Lys Trp Leu Leu Gly Leu Leu Leu Thr Trp Leu Leu Leu Leu Gly 
465                 470                 475                 480 


Leu Leu Phe Gly Leu Ile Ala Leu Ala Glu Glu Val Arg Lys Leu Lys 
                485                 490                 495     


Ala Arg Val Asp Glu Leu Glu Arg Ile Arg Arg Ser Ile Leu Pro Tyr 
            500                 505                 510         


Gly Asp Ser Met Asp Arg Ile Glu Lys Asp Arg Leu Gln Gly Met Ala 
        515                 520                 525             


Pro Ala Ala Gly Ala Asp Leu Asp Lys Ile Gly Leu His Ser Asp Ser 
    530                 535                 540                 


Gln Glu Glu Leu Trp Met Phe Val Arg Lys Lys Leu Met Met Glu Gln 
545                 550                 555                 560 


Glu Asn Gly Asn Leu Arg Gly Ser Pro Gly Pro Lys Gly Asp Met Gly 
                565                 570                 575     


Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile 
            580                 585                 590         


Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys 
        595                 600                 605             


Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Met Gly Gln Arg Gly 
    610                 615                 620                 


Arg Glu Gly Pro Met Gly Pro Arg Gly Glu Ala Gly Pro Pro Gly Ser 
625                 630                 635                 640 


Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly 
                645                 650                 655     


Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser 
            660                 665                 670         


Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg 
        675                 680                 685             


Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly 
    690                 695                 700                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Arg Gly Leu 
705                 710                 715                 720 


Thr Gly Glu Pro Gly Met Arg Gly Leu Pro Gly Ala Val Gly Glu Pro 
                725                 730                 735     


Gly Ala Lys Gly Ala Met Gly Pro Ala Gly Pro Asp Gly His Gln Gly 
            740                 745                 750         


Pro Arg Gly Glu Gln Gly Leu Thr Gly Met Pro Gly Ile Arg Gly Pro 
        755                 760                 765             


Pro Gly Pro Ser Gly Asp Pro Gly Lys Pro Gly Leu Thr Gly Pro Gln 
    770                 775                 780                 


Gly Pro Gln Gly Leu Pro Gly Thr Pro Gly Arg Pro Gly Ile Lys Gly 
785                 790                 795                 800 


Glu Pro Gly Ala Pro Gly Lys Ile Val Thr Ser Glu Gly Ser Ser Met 
                805                 810                 815     


Leu Thr Val Pro Gly Pro Pro Gly Pro Pro Gly Ala Met Gly Pro Pro 
            820                 825                 830         


Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Ala Gly Leu Pro Gly 
        835                 840                 845             


His Gln Glu Val Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 


Arg Gly Pro Pro Gly Pro Ser Ile Pro Gly Pro Pro Gly Pro Arg Gly 
865                 870                 875                 880 


Pro Pro Gly Glu Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Phe 
                885                 890                 895     


Leu Ser Asn Ser Glu Thr Phe Leu Ser Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         


Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly His 
        915                 920                 925             


Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Thr Ser Gly Ser Ser Ser 
    930                 935                 940                 


Phe Gly Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly 
945                 950                 955                 960 


Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile 
                965                 970                 975     


Pro Ser Gly Pro Ser Glu Gly Gly Ser Ser Ser Thr Met Tyr Val Ser 
            980                 985                 990         


Gly Pro Pro Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Ser Ile Ser 
        995                 1000                 1005             


Ser Ser  Gly Gln Glu Ile Gln  Gln Tyr Ile Ser Glu  Tyr Met Gln 
    1010                 1015                 1020             


Ser Asp  Ser Ile Arg Ser Tyr  Leu Ser Gly Val Gln  Gly Pro Pro 
    1025                 1030                 1035             


Gly Pro  Pro Gly Pro Pro Gly  Pro Val Thr Thr Ile  Thr Gly Glu 
    1040                 1045                 1050             


Thr Phe  Asp Tyr Ser Glu Leu  Ala Ser His Val Val  Ser Tyr Leu 
    1055                 1060                 1065             


Arg Thr  Ser Gly Tyr Gly Val  Ser Leu Phe Ser Ser  Ser Ile Ser 
    1070                 1075                 1080             


Ser Glu  Asp Ile Leu Ala Val  Leu Gln Arg Asp Asp  Val Arg Gln 
    1085                 1090                 1095             


Tyr Leu  Arg Gln Tyr Leu Met  Gly Pro Arg Gly Pro  Pro Gly Pro 
    1100                 1105                 1110             


Pro Gly  Ala Ser Gly Asp Gly  Ser Leu Leu Ser Leu  Asp Tyr Ala 
    1115                 1120                 1125             


Glu Leu  Ser Ser Arg Ile Leu  Ser Tyr Met Ser Ser  Ser Gly Ile 
    1130                 1135                 1140             


Ser Ile  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly 
    1145                 1150                 1155             


Thr Ser  Tyr Glu Glu Leu Leu  Ser Leu Leu Arg Gly  Ser Glu Phe 
    1160                 1165                 1170             


Arg Gly  Ile Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ile 
    1175                 1180                 1185             


Pro Gly  Asn Val Trp Ser Ser  Ile Ser Val Glu Asp  Leu Ser Ser 
    1190                 1195                 1200             


Tyr Leu  His Thr Ala Gly Leu  Ser Phe Ile Pro Gly  Pro Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Arg Gly Pro Pro Gly  Val Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Thr Tyr Ala Ala  Glu Asn Ser Asp Ser  Phe Arg Ser 
    1235                 1240                 1245             


Glu Leu  Ile Ser Tyr Leu Thr  Ser Pro Asp Val Arg  Ser Phe Ile 
    1250                 1255                 1260             


Val Gly  Pro Pro Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Asp 
    1265                 1270                 1275             


Ser Arg  Leu Leu Ser Thr Asp  Ala Ser His Ser Arg  Gly Ser Ser 
    1280                 1285                 1290             


Ser Ser  Ser His Ser Ser Ser  Val Arg Arg Gly Ser  Ser Tyr Ser 
    1295                 1300                 1305             


Ser Ser  Met Ser Thr Gly Gly  Gly Gly Ala Gly Ser  Leu Gly Ala 
    1310                 1315                 1320             


Gly Gly  Ala Phe Gly Glu Ala  Ala Gly Asp Arg Gly  Pro Tyr Gly 
    1325                 1330                 1335             


Thr Asp  Ile Gly Pro Gly Gly  Gly Tyr Gly Ala Ala  Ala Glu Gly 
    1340                 1345                 1350             


Gly Met  Tyr Ala Gly Asn Gly  Gly Leu Leu Gly Ala  Asp Phe Ala 
    1355                 1360                 1365             


Gly Asp  Leu Asp Tyr Asn Glu  Leu Ala Val Arg Val  Ser Glu Ser 
    1370                 1375                 1380             


Met Gln  Arg Gln Gly Leu Leu  Gln Gly Met Ala Tyr  Thr Val Gln 
    1385                 1390                 1395             


Gly Pro  Pro Gly Gln Pro Gly  Pro Gln Gly Pro Pro  Gly Ile Ser 
    1400                 1405                 1410             


Lys Val  Phe Ser Ala Tyr Ser  Asn Val Thr Ala Asp  Leu Met Asp 
    1415                 1420                 1425             


Phe Phe  Gln Thr Tyr Gly Ala  Ile Gln Gly Pro Pro  Gly Gln Lys 
    1430                 1435                 1440             


Gly Glu  Met Gly Thr Pro Gly  Pro Lys Gly Asp Arg  Gly Pro Ala 
    1445                 1450                 1455             


Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Pro Arg  Gly His Lys 
    1460                 1465                 1470             


Gly Glu  Lys Gly Asp Lys Gly  Asp Gln Val Tyr Ala  Gly Arg Arg 
    1475                 1480                 1485             


Arg Arg  Arg Ser Ile Ala Val  Lys Pro 
    1490                 1495         


<210>  2402
<211>  1516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL18A1__Homo_sapiens__NP_085059

<400>  2402

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 
    210                 215                 220                 


Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 
225                 230                 235                 240 


Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 
                245                 250                 255     


Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 
            260                 265                 270         


Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 
        275                 280                 285             


Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 
    290                 295                 300                 


Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 
305                 310                 315                 320 


Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 
                325                 330                 335     


Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 
            340                 345                 350         


Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 
        355                 360                 365             


Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 
    370                 375                 380                 


Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 
385                 390                 395                 400 


Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 
                405                 410                 415     


Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly 
            420                 425                 430         


Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 
        435                 440                 445             


Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 
    450                 455                 460                 


Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 
465                 470                 475                 480 


Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 
                485                 490                 495     


Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 
            500                 505                 510         


Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 
        515                 520                 525             


Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly 
    530                 535                 540                 


Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro 
545                 550                 555                 560 


Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
                565                 570                 575     


Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu 
            580                 585                 590         


Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 
        595                 600                 605             


Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 
    610                 615                 620                 


Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 
625                 630                 635                 640 


Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 
                645                 650                 655     


Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro 
            660                 665                 670         


Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val 
    690                 695                 700                 


Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 
                725                 730                 735     


Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 
        755                 760                 765             


Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro 
785                 790                 795                 800 


Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly 
                805                 810                 815     


Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala 
            820                 825                 830         


Lys Gly Glu Val Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 
    850                 855                 860                 


Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 
                885                 890                 895     


Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro 
            900                 905                 910         


Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly 
        915                 920                 925             


Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu 
    930                 935                 940                 


Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln 
945                 950                 955                 960 


Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 
                965                 970                 975     


Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 
            980                 985                 990         


Arg Pro Gly Met Asn Gly Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp 
        995                 1000                 1005             


Ala Ser  Leu Gly Phe Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser 
    1025                 1030                 1035             


Asn Val  Phe Ala Glu Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Asn  Gln Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val 
    1055                 1060                 1065             


Gly Pro  Pro Gly Pro Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln 
    1070                 1075                 1080             


Leu Glu  Ala Glu Met Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala 
    1085                 1090                 1095             


Gly Gln  Lys Gly Glu Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe 
    1100                 1105                 1110             


Gly Ser  Ser Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly 
    1115                 1120                 1125             


Tyr Pro  Gly Ile Pro Gly Pro  Lys Gly Glu Ser Ile  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Ile  Gly Tyr Glu 
    1145                 1150                 1155             


Gly Arg  Gln Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1160                 1165                 1170             


Ser Phe  Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 
    1190                 1195                 1200             


Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 
    1205                 1210                 1215             


Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 
    1220                 1225                 1230             


Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 
    1235                 1240                 1245             


Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 
    1250                 1255                 1260             


Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 
    1265                 1270                 1275             


Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 
    1280                 1285                 1290             


Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 
    1295                 1300                 1305             


Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 
    1310                 1315                 1320             


Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 
    1325                 1330                 1335             


Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 
    1340                 1345                 1350             


Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 
    1355                 1360                 1365             


Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 
    1370                 1375                 1380             


Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 
    1385                 1390                 1395             


Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 
    1400                 1405                 1410             


Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 
    1415                 1420                 1425             


Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 
    1430                 1435                 1440             


His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 
    1445                 1450                 1455             


Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 
    1460                 1465                 1470             


Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 
    1475                 1480                 1485             


Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 
    1490                 1495                 1500             


Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 
    1505                 1510                 1515     


<210>  2403
<211>  1464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL1A1__Homo_sapiens__NP_000079

<400>  2403

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  2404
<211>  1366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL1A2__Homo_sapiens__NP_000080

<400>  2404

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  2405
<211>  1284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL20A1__Homo_sapiens__NP_065933

<400>  2405

Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp 
1               5                   10                  15      


Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu 
            20                  25                  30          


Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu 
        35                  40                  45              


Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala 
    50                  55                  60                  


Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala 
65                  70                  75                  80  


Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe 
                85                  90                  95      


Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val 
            100                 105                 110         


Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro 
        115                 120                 125             


Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro 
    130                 135                 140                 


Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln 
145                 150                 155                 160 


Asp Pro Arg Thr Pro Ala Gly Pro Gln Phe Arg Cys Leu Pro Pro Val 
                165                 170                 175     


Pro Ala Asp Met Val Phe Leu Val Asp Gly Ser Trp Ser Ile Gly His 
            180                 185                 190         


Ser His Phe Gln Gln Val Lys Asp Phe Leu Ala Ser Val Ile Ala Pro 
        195                 200                 205             


Phe Glu Ile Gly Pro Asp Lys Val Gln Val Gly Leu Thr Gln Tyr Ser 
    210                 215                 220                 


Gly Asp Ala Gln Thr Glu Trp Asp Leu Asn Ser Leu Ser Thr Lys Glu 
225                 230                 235                 240 


Gln Val Leu Ala Ala Val Arg Arg Leu Arg Tyr Lys Gly Gly Asn Thr 
                245                 250                 255     


Phe Thr Gly Leu Ala Leu Thr His Val Leu Gly Gln Asn Leu Gln Pro 
            260                 265                 270         


Ala Ala Gly Leu Arg Pro Glu Ala Ala Lys Val Val Ile Leu Val Thr 
        275                 280                 285             


Asp Gly Lys Ser Gln Asp Asp Val His Thr Ala Ala Arg Val Leu Lys 
    290                 295                 300                 


Asp Leu Gly Val Asn Val Phe Ala Val Gly Val Lys Asn Ala Asp Glu 
305                 310                 315                 320 


Ala Glu Leu Arg Leu Leu Ala Ser Pro Pro Arg Asp Ile Thr Val His 
                325                 330                 335     


Ser Val Leu Asp Phe Leu Gln Leu Gly Ala Leu Ala Gly Leu Leu Ser 
            340                 345                 350         


Arg Leu Ile Cys Gln Arg Leu Gln Gly Gly Ser Pro Arg Gln Gly Pro 
        355                 360                 365             


Ala Ala Ala Pro Ala Leu Asp Thr Leu Pro Ala Pro Thr Ser Leu Val 
    370                 375                 380                 


Leu Ser Gln Val Thr Ser Ser Ser Ile Arg Leu Ser Trp Thr Pro Ala 
385                 390                 395                 400 


Pro Arg His Pro Leu Lys Tyr Leu Ile Val Trp Arg Ala Ser Arg Gly 
                405                 410                 415     


Gly Thr Pro Arg Glu Val Val Val Glu Gly Pro Ala Ala Ser Thr Glu 
            420                 425                 430         


Leu His Asn Leu Ala Ser Arg Thr Glu Tyr Leu Val Ser Val Phe Pro 
        435                 440                 445             


Ile Tyr Glu Gly Gly Val Gly Glu Gly Leu Arg Gly Leu Val Thr Thr 
    450                 455                 460                 


Ala Pro Leu Pro Pro Pro Arg Ala Leu Thr Leu Ala Ala Val Thr Pro 
465                 470                 475                 480 


Arg Thr Val His Leu Thr Trp Gln Pro Ser Ala Gly Ala Thr His Tyr 
                485                 490                 495     


Leu Val Arg Cys Ser Pro Ala Ser Pro Lys Gly Glu Glu Glu Glu Arg 
            500                 505                 510         


Glu Val Gln Val Gly Arg Pro Glu Val Leu Leu Asp Gly Leu Glu Pro 
        515                 520                 525             


Gly Arg Asp Tyr Glu Val Ser Val Gln Ser Leu Arg Gly Pro Glu Gly 
    530                 535                 540                 


Ser Glu Ala Arg Gly Ile Arg Ala Arg Thr Pro Thr Leu Ala Pro Pro 
545                 550                 555                 560 


Arg His Leu Gly Phe Ser Asp Val Ser His Asp Ala Ala Arg Val Phe 
                565                 570                 575     


Trp Glu Gly Ala Pro Arg Pro Val Arg Leu Val Arg Val Thr Tyr Val 
            580                 585                 590         


Ser Ser Glu Gly Gly His Ser Gly Gln Thr Glu Ala Pro Gly Asn Ala 
        595                 600                 605             


Thr Ser Ala Thr Leu Gly Pro Leu Ser Ser Ser Thr Thr Tyr Thr Val 
    610                 615                 620                 


Arg Val Thr Cys Leu Tyr Pro Gly Gly Gly Ser Ser Thr Leu Thr Gly 
625                 630                 635                 640 


Arg Val Thr Thr Lys Lys Ala Pro Ser Pro Ser Gln Leu Ser Met Thr 
                645                 650                 655     


Glu Leu Pro Gly Asp Ala Val Gln Leu Ala Trp Val Ala Ala Ala Pro 
            660                 665                 670         


Ser Gly Val Leu Val Tyr Gln Ile Thr Trp Thr Pro Leu Gly Glu Gly 
        675                 680                 685             


Lys Ala His Glu Ile Ser Val Pro Gly Asn Leu Gly Thr Ala Val Leu 
    690                 695                 700                 


Pro Gly Leu Gly Arg His Thr Glu Tyr Asp Val Thr Ile Leu Ala Tyr 
705                 710                 715                 720 


Tyr Arg Asp Gly Ala Arg Ser Asp Pro Val Ser Leu Arg Tyr Thr Pro 
                725                 730                 735     


Ser Thr Val Ser Arg Ser Pro Pro Ser Asn Leu Ala Leu Ala Ser Glu 
            740                 745                 750         


Thr Pro Asp Ser Leu Gln Val Ser Trp Thr Pro Pro Leu Gly Arg Val 
        755                 760                 765             


Leu His Tyr Trp Leu Thr Tyr Ala Pro Ala Ser Gly Leu Gly Pro Glu 
    770                 775                 780                 


Lys Ser Val Ser Val Pro Gly Ala Arg Ser His Val Thr Leu Pro Asp 
785                 790                 795                 800 


Leu Gln Ala Ala Thr Lys Tyr Arg Val Leu Val Ser Ala Ile Tyr Ala 
                805                 810                 815     


Ala Gly Arg Ser Glu Ala Val Ser Ala Thr Gly Gln Thr Ala Cys Pro 
            820                 825                 830         


Ala Leu Arg Pro Asp Gly Ser Leu Pro Gly Phe Asp Leu Met Val Ala 
        835                 840                 845             


Phe Ser Leu Val Glu Lys Ala Tyr Ala Ser Ile Arg Gly Val Ala Met 
    850                 855                 860                 


Glu Pro Ser Ala Phe Gly Gly Thr Pro Thr Phe Thr Leu Phe Lys Asp 
865                 870                 875                 880 


Ala Gln Leu Thr Arg Arg Val Ser Asp Val Tyr Pro Ala Pro Leu Pro 
                885                 890                 895     


Pro Glu His Thr Ile Val Phe Leu Val Arg Leu Leu Pro Glu Thr Pro 
            900                 905                 910         


Arg Glu Ala Phe Ala Leu Trp Gln Met Thr Ala Glu Asp Phe Gln Pro 
        915                 920                 925             


Leu Leu Gly Val Leu Leu Asp Ala Gly Lys Lys Ser Leu Thr Tyr Phe 
    930                 935                 940                 


His Arg Asp Pro Arg Ala Ala Leu Gln Glu Ala Thr Phe Asp Pro Gln 
945                 950                 955                 960 


Glu Val Arg Lys Ile Phe Phe Gly Ser Phe His Lys Val His Val Ala 
                965                 970                 975     


Val Gly Arg Ser Lys Val Arg Leu Tyr Val Asp Cys Arg Lys Val Ala 
            980                 985                 990         


Glu Arg Pro Leu Gly Glu Met Gly  Ser Pro Pro Ala Ala  Gly Phe Val 
        995                 1000                 1005             


Thr Leu  Gly Arg Leu Ala Lys  Ala Arg Gly Pro Arg  Ser Ser Ser 
    1010                 1015                 1020             


Ala Ala  Phe Gln Leu Gln Met  Leu Gln Ile Val Cys  Ser Asp Thr 
    1025                 1030                 1035             


Trp Ala  Asp Glu Asp Arg Cys  Cys Glu Leu Pro Ala  Ser Arg Asp 
    1040                 1045                 1050             


Gly Glu  Thr Cys Pro Ala Phe  Val Ser Ala Cys Ser  Cys Ser Ser 
    1055                 1060                 1065             


Glu Thr  Pro Gly Pro Pro Gly  Pro Gln Gly Pro Pro  Gly Leu Pro 
    1070                 1075                 1080             


Gly Arg  Asn Gly Thr Pro Gly  Glu Gln Gly Phe Pro  Gly Pro Arg 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Lys Gly  Glu Lys Gly Asp His  Gly Leu Pro 
    1100                 1105                 1110             


Gly Leu  Gln Gly His Pro Gly  His Gln Gly Ile Pro  Gly Arg Val 
    1115                 1120                 1125             


Gly Leu  Gln Gly Pro Lys Gly  Met Arg Gly Leu Glu  Gly Thr Ala 
    1130                 1135                 1140             


Gly Leu  Pro Gly Pro Pro Gly  Pro Arg Gly Phe Gln  Gly Met Ala 
    1145                 1150                 1155             


Gly Ala  Arg Gly Thr Ser Gly  Glu Arg Gly Pro Pro  Gly Thr Val 
    1160                 1165                 1170             


Gly Pro  Thr Gly Leu Pro Gly  Pro Lys Gly Glu Arg  Gly Glu Lys 
    1175                 1180                 1185             


Gly Glu  Pro Gln Ser Leu Ala  Thr Leu Tyr Gln Leu  Val Ser Gln 
    1190                 1195                 1200             


Ala Ser  His Val Ser Lys Phe  Asp Ser Phe His Glu  Asn Thr Arg 
    1205                 1210                 1215             


Pro Pro  Met Pro Ile Leu Glu  Gln Lys Leu Glu Pro  Gly Thr Glu 
    1220                 1225                 1230             


Pro Leu  Gly Ser Pro Gly Thr  Arg Ser Lys Ala Leu  Val Pro Gly 
    1235                 1240                 1245             


Glu Trp  Gly Arg Gly Gly Arg  His Leu Glu Gly Arg  Gly Glu Pro 
    1250                 1255                 1260             


Gly Ala  Val Gly Gln Met Gly  Ser Pro Gly Gln Gln  Gly Ala Ser 
    1265                 1270                 1275             


Thr Gln  Gly Leu Trp Glu 
    1280                 


<210>  2406
<211>  957
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL21A1__Homo_sapiens__NP_110447

<400>  2406

Met Ala His Tyr Ile Thr Phe Leu Cys Met Val Leu Val Leu Leu Leu 
1               5                   10                  15      


Gln Asn Ser Val Leu Ala Glu Asp Gly Glu Val Arg Ser Ser Cys Arg 
            20                  25                  30          


Thr Ala Pro Thr Asp Leu Val Phe Ile Leu Asp Gly Ser Tyr Ser Val 
        35                  40                  45              


Gly Pro Glu Asn Phe Glu Ile Val Lys Lys Trp Leu Val Asn Ile Thr 
    50                  55                  60                  


Lys Asn Phe Asp Ile Gly Pro Lys Phe Ile Gln Val Gly Val Val Gln 
65                  70                  75                  80  


Tyr Ser Asp Tyr Pro Val Leu Glu Ile Pro Leu Gly Ser Tyr Asp Ser 
                85                  90                  95      


Gly Glu His Leu Thr Ala Ala Val Glu Ser Ile Leu Tyr Leu Gly Gly 
            100                 105                 110         


Asn Thr Lys Thr Gly Lys Ala Ile Gln Phe Ala Leu Asp Tyr Leu Phe 
        115                 120                 125             


Ala Lys Ser Ser Arg Phe Leu Thr Lys Ile Ala Val Val Leu Thr Asp 
    130                 135                 140                 


Gly Lys Ser Gln Asp Asp Val Lys Asp Ala Ala Gln Ala Ala Arg Asp 
145                 150                 155                 160 


Ser Lys Ile Thr Leu Phe Ala Ile Gly Val Gly Ser Glu Thr Glu Asp 
                165                 170                 175     


Ala Glu Leu Arg Ala Ile Ala Asn Lys Pro Ser Ser Thr Tyr Val Phe 
            180                 185                 190         


Tyr Val Glu Asp Tyr Ile Ala Ile Ser Lys Ile Arg Glu Val Met Lys 
        195                 200                 205             


Gln Lys Leu Cys Glu Glu Ser Val Cys Pro Thr Arg Ile Pro Val Ala 
    210                 215                 220                 


Ala Arg Asp Glu Arg Gly Phe Asp Ile Leu Leu Gly Leu Asp Val Asn 
225                 230                 235                 240 


Lys Lys Val Lys Lys Arg Ile Gln Leu Ser Pro Lys Lys Ile Lys Gly 
                245                 250                 255     


Tyr Glu Val Thr Ser Lys Val Asp Leu Ser Glu Leu Thr Ser Asn Val 
            260                 265                 270         


Phe Pro Glu Gly Leu Pro Pro Ser Tyr Val Phe Val Ser Thr Gln Arg 
        275                 280                 285             


Phe Lys Val Lys Lys Ile Trp Asp Leu Trp Arg Ile Leu Thr Ile Asp 
    290                 295                 300                 


Gly Arg Pro Gln Ile Ala Val Thr Leu Asn Gly Val Asp Lys Ile Leu 
305                 310                 315                 320 


Leu Phe Thr Thr Thr Ser Val Ile Asn Gly Ser Gln Val Val Thr Phe 
                325                 330                 335     


Ala Asn Pro Gln Val Lys Thr Leu Phe Asp Glu Gly Trp His Gln Ile 
            340                 345                 350         


Arg Leu Leu Val Thr Glu Gln Asp Val Thr Leu Tyr Ile Asp Asp Gln 
        355                 360                 365             


Gln Ile Glu Asn Lys Pro Leu His Pro Val Leu Gly Ile Leu Ile Asn 
    370                 375                 380                 


Gly Gln Thr Gln Ile Gly Lys Tyr Ser Gly Lys Glu Glu Thr Val Gln 
385                 390                 395                 400 


Phe Asp Val Gln Lys Leu Arg Ile Tyr Cys Asp Pro Glu Gln Asn Asn 
                405                 410                 415     


Arg Glu Thr Ala Cys Glu Ile Pro Gly Phe Asn Gly Glu Cys Leu Asn 
            420                 425                 430         


Gly Pro Ser Asp Val Gly Ser Thr Pro Ala Pro Cys Ile Cys Pro Pro 
        435                 440                 445             


Gly Lys Pro Gly Leu Gln Gly Pro Lys Gly Asp Pro Gly Leu Pro Gly 
    450                 455                 460                 


Asn Pro Gly Tyr Pro Gly Gln Pro Gly Gln Asp Gly Lys Pro Gly Tyr 
465                 470                 475                 480 


Gln Gly Ile Ala Gly Thr Pro Gly Val Pro Gly Ser Pro Gly Ile Gln 
                485                 490                 495     


Gly Ala Arg Gly Leu Pro Gly Tyr Lys Gly Glu Pro Gly Arg Asp Gly 
            500                 505                 510         


Asp Lys Gly Asp Arg Gly Leu Pro Gly Phe Pro Gly Leu His Gly Met 
        515                 520                 525             


Pro Gly Ser Lys Gly Glu Met Gly Ala Lys Gly Asp Lys Gly Ser Pro 
    530                 535                 540                 


Gly Phe Tyr Gly Lys Lys Gly Ala Lys Gly Glu Lys Gly Asn Ala Gly 
545                 550                 555                 560 


Phe Pro Gly Leu Pro Gly Pro Ala Gly Glu Pro Gly Arg His Gly Lys 
                565                 570                 575     


Asp Gly Leu Met Gly Ser Pro Gly Phe Lys Gly Glu Ala Gly Ser Pro 
            580                 585                 590         


Gly Ala Pro Gly Gln Asp Gly Thr Arg Gly Glu Pro Gly Ile Pro Gly 
        595                 600                 605             


Phe Pro Gly Asn Arg Gly Leu Met Gly Gln Lys Gly Glu Ile Gly Pro 
    610                 615                 620                 


Pro Gly Gln Gln Gly Lys Lys Gly Ala Pro Gly Met Pro Gly Leu Met 
625                 630                 635                 640 


Gly Ser Asn Gly Ser Pro Gly Gln Pro Gly Thr Pro Gly Ser Lys Gly 
                645                 650                 655     


Ser Lys Gly Glu Pro Gly Ile Gln Gly Met Pro Gly Ala Ser Gly Leu 
            660                 665                 670         


Lys Gly Glu Pro Gly Ala Thr Gly Ser Pro Gly Glu Pro Gly Tyr Met 
        675                 680                 685             


Gly Leu Pro Gly Ile Gln Gly Lys Lys Gly Asp Lys Gly Asn Gln Gly 
    690                 695                 700                 


Glu Lys Gly Ile Gln Gly Gln Lys Gly Glu Asn Gly Arg Gln Gly Ile 
705                 710                 715                 720 


Pro Gly Gln Gln Gly Ile Gln Gly His His Gly Ala Lys Gly Glu Arg 
                725                 730                 735     


Gly Glu Lys Gly Glu Pro Gly Val Arg Gly Ala Ile Gly Ser Lys Gly 
            740                 745                 750         


Glu Ser Gly Val Asp Gly Leu Met Gly Pro Ala Gly Pro Lys Gly Gln 
        755                 760                 765             


Pro Gly Asp Pro Gly Pro Gln Gly Pro Pro Gly Leu Asp Gly Lys Pro 
    770                 775                 780                 


Gly Arg Glu Phe Ser Glu Gln Phe Ile Arg Gln Val Cys Thr Asp Val 
785                 790                 795                 800 


Ile Arg Ala Gln Leu Pro Val Leu Leu Gln Ser Gly Arg Ile Arg Asn 
                805                 810                 815     


Cys Asp His Cys Leu Ser Gln His Gly Ser Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Ile Gly Pro Glu Gly Pro Arg Gly Leu Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Asp Gly Val Pro Gly Leu Val Gly Val Pro Gly Arg Pro Gly 
    850                 855                 860                 


Val Arg Gly Leu Lys Gly Leu Pro Gly Arg Asn Gly Glu Lys Gly Ser 
865                 870                 875                 880 


Gln Gly Phe Gly Tyr Pro Gly Glu Gln Gly Pro Pro Gly Pro Pro Gly 
                885                 890                 895     


Pro Glu Gly Pro Pro Gly Ile Ser Lys Glu Gly Pro Pro Gly Asp Pro 
            900                 905                 910         


Gly Leu Pro Gly Lys Asp Gly Asp His Gly Lys Pro Gly Ile Gln Gly 
        915                 920                 925             


Gln Pro Gly Pro Pro Gly Ile Cys Asp Pro Ser Leu Cys Phe Ser Val 
    930                 935                 940                 


Ile Ala Arg Arg Asp Pro Phe Arg Lys Gly Pro Asn Tyr 
945                 950                 955         


<210>  2407
<211>  1626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL22A1__Homo_sapiens__NP_690848

<400>  2407

Met Ala Gly Leu Arg Gly Asn Ala Val Ala Gly Leu Leu Trp Met Leu 
1               5                   10                  15      


Leu Leu Trp Ser Gly Gly Gly Gly Cys Gln Ala Gln Arg Ala Gly Cys 
            20                  25                  30          


Lys Ser Val His Tyr Asp Leu Val Phe Leu Leu Asp Thr Ser Ser Ser 
        35                  40                  45              


Val Gly Lys Glu Asp Phe Glu Lys Val Arg Gln Trp Val Ala Asn Leu 
    50                  55                  60                  


Val Asp Thr Phe Glu Val Gly Pro Asp Arg Thr Arg Val Gly Val Val 
65                  70                  75                  80  


Arg Tyr Ser Asp Arg Pro Thr Thr Ala Phe Glu Leu Gly Leu Phe Gly 
                85                  90                  95      


Ser Gln Glu Glu Val Lys Ala Ala Ala Arg Arg Leu Ala Tyr His Gly 
            100                 105                 110         


Gly Asn Thr Asn Thr Gly Asp Ala Leu Arg Tyr Ile Thr Ala Arg Ser 
        115                 120                 125             


Phe Ser Pro His Ala Gly Gly Arg Pro Arg Asp Arg Ala Tyr Lys Gln 
    130                 135                 140                 


Val Ala Ile Leu Leu Thr Asp Gly Arg Ser Gln Asp Leu Val Leu Asp 
145                 150                 155                 160 


Ala Ala Ala Ala Ala His Arg Ala Gly Ile Arg Ile Phe Ala Val Gly 
                165                 170                 175     


Val Gly Glu Ala Leu Lys Glu Glu Leu Glu Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Lys Ser Ala His Val Phe His Val Ser Asp Phe Asn Ala Ile Asp Lys 
        195                 200                 205             


Ile Arg Gly Lys Leu Arg Arg Arg Leu Cys Glu Asn Val Leu Cys Pro 
    210                 215                 220                 


Ser Val Arg Val Glu Gly Asp Arg Phe Lys His Thr Asn Gly Gly Thr 
225                 230                 235                 240 


Lys Glu Ile Thr Gly Phe Asp Leu Met Asp Leu Phe Ser Val Lys Glu 
                245                 250                 255     


Ile Leu Gly Lys Arg Glu Asn Gly Ala Gln Ser Ser Tyr Val Arg Met 
            260                 265                 270         


Gly Ser Phe Pro Val Val Gln Ser Thr Glu Asp Val Phe Pro Gln Gly 
        275                 280                 285             


Leu Pro Asp Glu Tyr Ala Phe Val Thr Thr Phe Arg Phe Arg Lys Thr 
    290                 295                 300                 


Ser Arg Lys Glu Asp Trp Tyr Ile Trp Gln Val Ile Asp Gln Tyr Ser 
305                 310                 315                 320 


Ile Pro Gln Val Ser Ile Arg Leu Asp Gly Glu Asn Lys Ala Val Glu 
                325                 330                 335     


Tyr Asn Ala Val Gly Ala Met Lys Asp Ala Val Arg Val Val Phe Arg 
            340                 345                 350         


Gly Ser Arg Val Asn Asp Leu Phe Asp Arg Asp Trp His Lys Met Ala 
        355                 360                 365             


Leu Ser Ile Gln Ala Gln Asn Val Ser Leu His Ile Asp Cys Ala Leu 
    370                 375                 380                 


Val Gln Thr Leu Pro Ile Glu Glu Arg Glu Asn Ile Asp Ile Gln Gly 
385                 390                 395                 400 


Lys Thr Val Ile Gly Lys Arg Leu Tyr Asp Ser Val Pro Ile Asp Phe 
                405                 410                 415     


Asp Leu Gln Arg Ile Val Ile Tyr Cys Asp Ser Arg His Ala Glu Leu 
            420                 425                 430         


Glu Thr Cys Cys Asp Ile Pro Ser Gly Pro Cys Gln Val Thr Val Val 
        435                 440                 445             


Thr Glu Pro Pro Pro Pro Pro Pro Pro Gln Arg Pro Pro Thr Pro Gly 
    450                 455                 460                 


Ser Glu Gln Ile Gly Phe Leu Lys Thr Ile Asn Cys Ser Cys Pro Ala 
465                 470                 475                 480 


Gly Glu Lys Gly Glu Met Gly Val Ala Gly Pro Met Gly Leu Pro Gly 
                485                 490                 495     


Pro Lys Gly Asp Ile Gly Ala Ile Gly Pro Val Gly Ala Pro Gly Pro 
            500                 505                 510         


Lys Gly Glu Lys Gly Asp Val Gly Ile Gly Pro Phe Gly Gln Gly Glu 
        515                 520                 525             


Lys Gly Glu Lys Gly Ser Leu Gly Leu Pro Gly Pro Pro Gly Arg Asp 
    530                 535                 540                 


Gly Ser Lys Gly Met Arg Gly Glu Pro Gly Glu Leu Gly Glu Pro Gly 
545                 550                 555                 560 


Leu Pro Gly Glu Val Gly Met Arg Gly Pro Gln Gly Pro Pro Gly Leu 
                565                 570                 575     


Pro Gly Pro Pro Gly Arg Val Gly Ala Pro Gly Leu Gln Gly Glu Arg 
            580                 585                 590         


Gly Glu Lys Gly Thr Arg Gly Glu Lys Gly Glu Arg Gly Leu Asp Gly 
        595                 600                 605             


Phe Pro Gly Lys Pro Gly Asp Thr Gly Gln Gln Gly Arg Pro Gly Pro 
    610                 615                 620                 


Ser Gly Val Ala Gly Pro Gln Gly Glu Lys Gly Asp Val Gly Pro Ala 
625                 630                 635                 640 


Gly Pro Pro Gly Val Pro Gly Ser Val Val Gln Gln Glu Gly Leu Lys 
                645                 650                 655     


Gly Glu Gln Gly Ala Pro Gly Pro Arg Gly His Gln Gly Ala Pro Gly 
            660                 665                 670         


Pro Pro Gly Ala Arg Gly Pro Ile Gly Pro Glu Gly Arg Asp Gly Pro 
        675                 680                 685             


Pro Gly Leu Gln Gly Leu Arg Gly Lys Lys Gly Asp Met Gly Pro Pro 
    690                 695                 700                 


Gly Ile Pro Gly Leu Leu Gly Leu Gln Gly Pro Pro Gly Pro Pro Gly 
705                 710                 715                 720 


Val Pro Gly Pro Pro Gly Pro Gly Gly Ser Pro Gly Leu Pro Gly Glu 
                725                 730                 735     


Ile Gly Phe Pro Gly Lys Pro Gly Pro Pro Gly Pro Thr Gly Pro Pro 
            740                 745                 750         


Gly Lys Asp Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly Thr Lys Gly 
        755                 760                 765             


Glu Pro Gly Glu Arg Gly Glu Asp Gly Leu Pro Gly Lys Pro Gly Leu 
    770                 775                 780                 


Arg Gly Glu Ile Gly Glu Gln Gly Leu Ala Gly Arg Pro Gly Glu Lys 
785                 790                 795                 800 


Gly Glu Ala Gly Leu Pro Gly Ala Pro Gly Phe Pro Gly Val Arg Gly 
                805                 810                 815     


Glu Lys Gly Asp Gln Gly Glu Lys Gly Glu Leu Gly Leu Pro Gly Leu 
            820                 825                 830         


Lys Gly Asp Arg Gly Glu Lys Gly Glu Ala Gly Pro Ala Gly Pro Pro 
        835                 840                 845             


Gly Leu Pro Gly Thr Thr Ser Leu Phe Thr Pro His Pro Arg Met Pro 
    850                 855                 860                 


Gly Glu Gln Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly Leu Pro Gly 
865                 870                 875                 880 


Glu Pro Gly Leu Gln Gly Arg Pro Gly Glu Leu Gly Pro Gln Gly Pro 
                885                 890                 895     


Thr Gly Pro Pro Gly Ala Lys Gly Gln Glu Gly Ala His Gly Ala Pro 
            900                 905                 910         


Gly Ala Ala Gly Asn Pro Gly Ala Pro Gly His Val Gly Ala Pro Gly 
        915                 920                 925             


Pro Ser Gly Pro Pro Gly Ser Val Gly Ala Pro Gly Leu Arg Gly Thr 
    930                 935                 940                 


Pro Gly Lys Asp Gly Glu Arg Gly Glu Lys Gly Ala Ala Gly Glu Glu 
945                 950                 955                 960 


Gly Ser Pro Gly Pro Val Gly Pro Arg Gly Asp Pro Gly Ala Pro Gly 
                965                 970                 975     


Leu Pro Gly Pro Pro Gly Lys Gly Lys Asp Gly Glu Pro Gly Leu Arg 
            980                 985                 990         


Gly Ser Pro Gly Leu Pro Gly Pro  Leu Gly Thr Lys Ala  Ala Cys Gly 
        995                 1000                 1005             


Lys Val  Arg Gly Ser Glu Asn  Cys Ala Leu Gly Gly  Gln Cys Val 
    1010                 1015                 1020             


Lys Gly  Asp Arg Gly Ala Pro  Gly Ile Pro Gly Ser  Pro Gly Ser 
    1025                 1030                 1035             


Arg Gly  Asp Pro Gly Ile Gly  Val Ala Gly Pro Pro  Gly Pro Ser 
    1040                 1045                 1050             


Gly Pro  Pro Gly Asp Lys Gly  Ser Pro Gly Ser Arg  Gly Leu Pro 
    1055                 1060                 1065             


Gly Phe  Pro Gly Pro Gln Gly  Pro Ala Gly Arg Asp  Gly Ala Pro 
    1070                 1075                 1080             


Gly Asn  Pro Gly Glu Arg Gly  Pro Pro Gly Lys Pro  Gly Leu Ser 
    1085                 1090                 1095             


Ser Leu  Leu Ser Pro Gly Asp  Ile Asn Leu Leu Ala  Lys Asp Val 
    1100                 1105                 1110             


Cys Asn  Asp Cys Pro Pro Gly  Pro Pro Gly Leu Pro  Gly Leu Pro 
    1115                 1120                 1125             


Gly Phe  Lys Gly Asp Lys Gly  Val Pro Gly Lys Pro  Gly Arg Glu 
    1130                 1135                 1140             


Gly Thr  Glu Gly Lys Lys Gly  Glu Ala Gly Pro Pro  Gly Leu Pro 
    1145                 1150                 1155             


Gly Pro  Pro Gly Ile Ala Gly  Pro Gln Gly Ser Gln  Gly Glu Arg 
    1160                 1165                 1170             


Gly Ala  Asp Gly Glu Val Gly  Gln Lys Gly Asp Gln  Gly His Pro 
    1175                 1180                 1185             


Gly Val  Pro Gly Phe Met Gly  Pro Pro Gly Asn Pro  Gly Pro Pro 
    1190                 1195                 1200             


Gly Ala  Asp Gly Ile Ala Gly  Ala Ala Gly Pro Pro  Gly Ile Gln 
    1205                 1210                 1215             


Gly Ser  Pro Gly Lys Glu Gly  Pro Pro Gly Pro Gln  Gly Pro Ser 
    1220                 1225                 1230             


Gly Leu  Pro Gly Ile Pro Gly  Glu Glu Gly Lys Glu  Gly Arg Asp 
    1235                 1240                 1245             


Gly Lys  Pro Gly Pro Pro Gly  Glu Pro Gly Lys Ala  Gly Glu Pro 
    1250                 1255                 1260             


Gly Leu  Pro Gly Pro Glu Gly  Ala Arg Gly Pro Pro  Gly Phe Lys 
    1265                 1270                 1275             


Gly His  Thr Gly Asp Ser Gly  Ala Pro Gly Pro Arg  Gly Glu Ser 
    1280                 1285                 1290             


Gly Ala  Met Gly Leu Pro Gly  Gln Glu Gly Leu Pro  Gly Lys Asp 
    1295                 1300                 1305             


Gly Asp  Thr Gly Pro Thr Gly  Pro Gln Gly Pro Gln  Gly Pro Arg 
    1310                 1315                 1320             


Gly Pro  Pro Gly Lys Asn Gly  Ser Pro Gly Ser Pro  Gly Glu Pro 
    1325                 1330                 1335             


Gly Pro  Ser Gly Thr Pro Gly  Gln Lys Gly Ser Lys  Gly Glu Asn 
    1340                 1345                 1350             


Gly Ser  Pro Gly Leu Pro Gly  Phe Leu Gly Pro Arg  Gly Pro Pro 
    1355                 1360                 1365             


Gly Glu  Pro Gly Glu Lys Gly  Val Pro Gly Lys Glu  Gly Val Pro 
    1370                 1375                 1380             


Gly Lys  Pro Gly Glu Pro Gly  Phe Lys Gly Glu Arg  Gly Asp Pro 
    1385                 1390                 1395             


Gly Ile  Lys Gly Asp Lys Gly  Pro Pro Gly Gly Lys  Gly Gln Pro 
    1400                 1405                 1410             


Gly Asp  Pro Gly Ile Pro Gly  His Lys Gly His Thr  Gly Leu Met 
    1415                 1420                 1425             


Gly Pro  Gln Gly Leu Pro Gly  Glu Asn Gly Pro Val  Gly Pro Pro 
    1430                 1435                 1440             


Gly Pro  Pro Gly Gln Pro Gly  Phe Pro Gly Leu Arg  Gly Glu Ser 
    1445                 1450                 1455             


Pro Ser  Met Glu Thr Leu Arg  Arg Leu Ile Gln Glu  Glu Leu Gly 
    1460                 1465                 1470             


Lys Gln  Leu Glu Thr Arg Leu  Ala Tyr Leu Leu Ala  Gln Met Pro 
    1475                 1480                 1485             


Pro Ala  Tyr Met Lys Ser Ser  Gln Gly Arg Pro Gly  Pro Pro Gly 
    1490                 1495                 1500             


Pro Pro  Gly Lys Asp Gly Leu  Pro Gly Arg Ala Gly  Pro Met Gly 
    1505                 1510                 1515             


Glu Pro  Gly Arg Pro Gly Gln  Gly Gly Leu Glu Gly  Pro Ser Gly 
    1520                 1525                 1530             


Pro Ile  Gly Pro Lys Gly Glu  Arg Gly Ala Lys Gly  Asp Pro Gly 
    1535                 1540                 1545             


Ala Pro  Gly Val Gly Leu Arg  Gly Glu Met Gly Pro  Pro Gly Ile 
    1550                 1555                 1560             


Pro Gly  Gln Pro Gly Glu Pro  Gly Tyr Ala Lys Asp  Gly Leu Pro 
    1565                 1570                 1575             


Gly Ile  Pro Gly Pro Gln Gly  Glu Thr Gly Pro Ala  Gly His Pro 
    1580                 1585                 1590             


Gly Leu  Pro Gly Pro Pro Gly  Pro Pro Gly Gln Cys  Asp Pro Ser 
    1595                 1600                 1605             


Gln Cys  Ala Tyr Phe Ala Ser  Leu Ala Ala Arg Pro  Gly Asn Val 
    1610                 1615                 1620             


Lys Gly  Pro 
    1625     


<210>  2408
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL23A1__Homo_sapiens__NP_775736

<400>  2408

Met Gly Pro Gly Glu Arg Ala Gly Gly Gly Gly Asp Ala Gly Lys Gly 
1               5                   10                  15      


Asn Ala Ala Gly Gly Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Gly 
            20                  25                  30          


Ser Arg Ala Val Ser Ala Leu Cys Leu Leu Leu Ser Val Gly Ser Ala 
        35                  40                  45              


Ala Ala Cys Leu Leu Leu Gly Val Gln Ala Ala Ala Leu Gln Gly Arg 
    50                  55                  60                  


Val Ala Ala Leu Glu Glu Glu Arg Glu Leu Leu Arg Arg Ala Gly Pro 
65                  70                  75                  80  


Pro Gly Ala Leu Asp Ala Trp Ala Glu Pro His Leu Glu Arg Leu Leu 
                85                  90                  95      


Arg Glu Lys Leu Asp Gly Leu Ala Lys Ile Arg Thr Ala Arg Glu Ala 
            100                 105                 110         


Pro Ser Glu Cys Val Cys Pro Pro Gly Pro Pro Gly Arg Arg Gly Lys 
        115                 120                 125             


Pro Gly Arg Arg Gly Asp Pro Gly Pro Pro Gly Gln Ser Gly Arg Asp 
    130                 135                 140                 


Gly Tyr Pro Gly Pro Leu Gly Leu Asp Gly Lys Pro Gly Leu Pro Gly 
145                 150                 155                 160 


Pro Lys Gly Glu Lys Gly Ala Pro Gly Asp Phe Gly Pro Arg Gly Asp 
                165                 170                 175     


Gln Gly Gln Asp Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            180                 185                 190         


Gly Ala Arg Gly Pro Pro Gly Asp Thr Gly Lys Asp Gly Pro Arg Gly 
        195                 200                 205             


Ala Gln Gly Pro Ala Gly Pro Lys Gly Glu Pro Gly Gln Asp Gly Glu 
    210                 215                 220                 


Met Gly Pro Lys Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Val Pro 
225                 230                 235                 240 


Gly Lys Lys Gly Asp Asp Gly Thr Pro Ser Gln Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Lys Gly Glu Pro Gly Ser Met Gly Pro Arg Gly Glu Asn Gly Val 
            260                 265                 270         


Asp Gly Ala Pro Gly Pro Lys Gly Glu Pro Gly His Arg Gly Thr Asp 
        275                 280                 285             


Gly Ala Ala Gly Pro Arg Gly Ala Pro Gly Leu Lys Gly Glu Gln Gly 
    290                 295                 300                 


Asp Thr Val Val Ile Asp Tyr Asp Gly Arg Ile Leu Asp Ala Leu Lys 
305                 310                 315                 320 


Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly 
                325                 330                 335     


Ala Lys Gly Glu Leu Gly Leu Pro Gly Ala Pro Gly Ile Asp Gly Glu 
            340                 345                 350         


Lys Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Glu Pro Gly Pro Ala 
        355                 360                 365             


Gly Leu Lys Gly Glu Ala Gly Glu Met Gly Leu Ser Gly Leu Pro Gly 
    370                 375                 380                 


Ala Asp Gly Leu Lys Gly Glu Lys Gly Glu Ser Ala Ser Asp Ser Leu 
385                 390                 395                 400 


Gln Glu Ser Leu Ala Gln Leu Ile Val Glu Pro Gly Pro Pro Gly Pro 
                405                 410                 415     


Pro Gly Pro Pro Gly Pro Met Gly Leu Gln Gly Ile Gln Gly Pro Lys 
            420                 425                 430         


Gly Leu Asp Gly Ala Lys Gly Glu Lys Gly Ala Ser Gly Glu Arg Gly 
        435                 440                 445             


Pro Ser Gly Leu Pro Gly Pro Val Gly Pro Pro Gly Leu Ile Gly Leu 
    450                 455                 460                 


Pro Gly Thr Lys Gly Glu Lys Gly Arg Pro Gly Glu Pro Gly Leu Asp 
465                 470                 475                 480 


Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly Asp Arg Ser Glu Arg Gly 
                485                 490                 495     


Glu Lys Gly Glu Arg Gly Val Pro Gly Arg Lys Gly Val Lys Gly Gln 
            500                 505                 510         


Lys Gly Glu Pro Gly Pro Pro Gly Leu Asp Gln Pro Cys Pro Val Gly 
        515                 520                 525             


Pro Asp Gly Leu Pro Val Pro Gly Cys Trp His Lys 
    530                 535                 540 


<210>  2409
<211>  1696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL24A1__Homo_sapiens__XP_011539493

<400>  2409

Met His Leu Arg Ala His Arg Thr Arg Arg Gly Lys Val Ser Pro Thr 
1               5                   10                  15      


Ala Lys Thr Lys Ser Leu Leu His Phe Ile Val Leu Cys Val Ala Gly 
            20                  25                  30          


Val Val Val His Ala Gln Glu Gln Gly Ile Asp Ile Leu His Gln Leu 
        35                  40                  45              


Gly Leu Gly Gly Lys Asp Val Arg His Ser Ser Pro Ala Thr Ala Val 
    50                  55                  60                  


Pro Ser Ala Ser Thr Pro Leu Pro Gln Gly Val His Leu Thr Glu Ser 
65                  70                  75                  80  


Gly Val Ile Phe Lys Asn Asp Ala Tyr Ile Glu Thr Pro Phe Val Lys 
                85                  90                  95      


Ile Leu Pro Val Asn Leu Gly Gln Pro Phe Thr Ile Leu Thr Gly Leu 
            100                 105                 110         


Gln Ser His Arg Val Asn Asn Ala Phe Leu Phe Ser Ile Arg Asn Lys 
        115                 120                 125             


Asn Arg Leu Gln Leu Gly Val Gln Leu Leu Pro Lys Lys Leu Val Val 
    130                 135                 140                 


His Ile Arg Gly Lys Gln Pro Ala Val Phe Asn Tyr Ser Val His Asp 
145                 150                 155                 160 


Glu Gln Trp His Ser Phe Ala Ile Thr Ile Arg Asn Gln Ser Val Ser 
                165                 170                 175     


Met Phe Val Glu Cys Gly Lys Lys Tyr Phe Ser Thr Glu Thr Ile Pro 
            180                 185                 190         


Glu Val Gln Thr Phe Asp Ser Asn Ser Val Phe Thr Leu Gly Ser Met 
        195                 200                 205             


Asn Asn Asn Ser Ile His Phe Glu Gly Ile Val Cys Gln Leu Asp Ile 
    210                 215                 220                 


Ile Pro Ser Ala Glu Ala Ser Ala Asp Tyr Cys Arg Tyr Val Lys Gln 
225                 230                 235                 240 


Gln Cys Arg Gln Ala Asp Lys Tyr Gln Pro Glu Thr Ser Ile Pro Cys 
                245                 250                 255     


Thr Thr Leu Ile Pro Thr Lys Ile Pro Glu His Ser Pro Pro Pro Lys 
            260                 265                 270         


Leu Phe Ala Glu Lys Val Leu Ser Glu Asp Thr Phe Thr Glu Gly Lys 
        275                 280                 285             


Ser Ile Pro Asn Ile Ile Lys Asn Asp Ser Glu Thr Val Tyr Lys Arg 
    290                 295                 300                 


Gln Glu His Gln Ile Ser Arg Ser Gln Leu Ser Ser Leu Gln Ser Gly 
305                 310                 315                 320 


Asn Val Ser Ala Val Asp Leu Thr Asn His Gly Ile Gln Ala Lys Glu 
                325                 330                 335     


Met Ile Thr Glu Glu Asp Thr Gln Thr Asn Phe Ser Leu Ser Val Thr 
            340                 345                 350         


Thr His Arg Ile Ser Glu Ala Lys Met Asn Thr Lys Glu Lys Phe Ser 
        355                 360                 365             


Ser Leu Leu Asn Met Ser Asp Asn Ile Thr Gln His Asp Asp Arg Val 
    370                 375                 380                 


Thr Gly Leu Ser Leu Phe Lys Lys Met Pro Ser Ile Leu Pro Gln Ile 
385                 390                 395                 400 


Lys Gln Asp Thr Ile Thr Asn Leu Lys Lys Ala Ile Thr Ala Asn Leu 
                405                 410                 415     


His Thr Asn Glu Leu Met Glu Met Gln Pro Ile Leu Asn Thr Ser Leu 
            420                 425                 430         


His Arg Val Thr Asn Glu Pro Ser Val Asp Asn His Leu Asp Leu Arg 
        435                 440                 445             


Lys Glu Gly Glu Phe Tyr Pro Asp Ala Thr Tyr Pro Ile Glu Asn Ser 
    450                 455                 460                 


Tyr Glu Thr Glu Leu Tyr Asp Tyr Tyr Tyr Tyr Glu Asp Leu Asn Thr 
465                 470                 475                 480 


Met Leu Glu Met Glu Tyr Leu Arg Gly Pro Lys Gly Asp Thr Gly Pro 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Ala Gly Ile Pro Gly Pro Ser Gly Lys Arg 
            500                 505                 510         


Gly Pro Arg Gly Ile Pro Gly Pro His Gly Asn Pro Gly Leu Pro Gly 
        515                 520                 525             


Leu Pro Gly Pro Lys Gly Pro Lys Gly Asp Pro Gly Phe Ser Pro Gly 
    530                 535                 540                 


Gln Pro Val Pro Gly Glu Lys Gly Asp Gln Gly Leu Ser Gly Leu Met 
545                 550                 555                 560 


Gly Pro Pro Gly Met Gln Gly Asp Lys Gly Leu Lys Gly His Pro Gly 
                565                 570                 575     


Leu Pro Gly Leu Pro Gly Glu Gln Gly Ile Pro Gly Phe Ala Gly Asn 
            580                 585                 590         


Ile Gly Ser Pro Gly Tyr Pro Gly Arg Gln Gly Leu Ala Gly Pro Glu 
        595                 600                 605             


Gly Asn Pro Gly Pro Lys Gly Ala Gln Gly Phe Ile Gly Ser Pro Gly 
    610                 615                 620                 


Glu Ala Gly Gln Leu Gly Pro Glu Gly Glu Arg Gly Ile Pro Gly Ile 
625                 630                 635                 640 


Arg Gly Lys Lys Gly Phe Lys Gly Arg Gln Gly Phe Pro Gly Asp Phe 
                645                 650                 655     


Gly Asp Arg Gly Pro Ala Gly Leu Asp Gly Ser Pro Gly Leu Val Gly 
            660                 665                 670         


Gly Thr Gly Pro Pro Gly Phe Pro Gly Leu Arg Gly Ser Val Gly Pro 
        675                 680                 685             


Val Gly Pro Ile Gly Pro Ala Gly Ile Pro Gly Pro Met Gly Leu Ser 
    690                 695                 700                 


Gly Asn Lys Gly Leu Pro Gly Ile Lys Gly Asp Lys Gly Glu Gln Gly 
705                 710                 715                 720 


Thr Ala Gly Glu Leu Gly Glu Pro Gly Tyr Pro Gly Asp Lys Gly Ala 
                725                 730                 735     


Val Gly Leu Pro Gly Pro Pro Gly Met Arg Gly Lys Ser Gly Pro Ser 
            740                 745                 750         


Gly Gln Thr Gly Asp Pro Gly Leu Gln Gly Pro Ser Gly Pro Pro Gly 
        755                 760                 765             


Pro Glu Gly Phe Pro Gly Asp Ile Gly Ile Pro Gly Gln Asn Gly Pro 
    770                 775                 780                 


Glu Gly Pro Lys Gly Leu Leu Gly Asn Arg Gly Pro Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Leu Lys Gly Thr Gln Gly Glu Glu Gly Pro Ile Gly Ala Phe Gly 
                805                 810                 815     


Glu Leu Gly Pro Arg Gly Lys Pro Gly Gln Lys Gly Tyr Ala Gly Glu 
            820                 825                 830         


Pro Gly Pro Glu Gly Leu Lys Gly Glu Val Gly Asp Gln Gly Asn Ile 
        835                 840                 845             


Gly Lys Ile Gly Glu Thr Gly Pro Val Gly Leu Pro Gly Glu Val Gly 
    850                 855                 860                 


Met Thr Gly Ser Ile Gly Glu Lys Gly Glu Arg Gly Ser Pro Gly Pro 
865                 870                 875                 880 


Leu Gly Pro Gln Gly Glu Lys Gly Val Met Gly Tyr Pro Gly Pro Pro 
                885                 890                 895     


Gly Val Pro Gly Pro Ile Gly Pro Leu Gly Leu Pro Gly Ser Arg Gly 
            900                 905                 910         


Pro Asp Gly Leu Leu Gly Glu Gln Gly Ile Gln Gly Ala Lys Gly Glu 
        915                 920                 925             


Lys Gly Asp Gln Gly Lys Arg Gly Pro His Gly Leu Ile Gly Lys Thr 
    930                 935                 940                 


Gly Asn Pro Gly Glu Arg Gly Phe Gln Gly Lys Pro Gly Leu Gln Gly 
945                 950                 955                 960 


Leu Pro Gly Ser Thr Gly Asp Arg Gly Leu Pro Gly Glu Pro Gly Leu 
                965                 970                 975     


Arg Gly Leu Gln Gly Asp Val Gly Pro Pro Gly Glu Met Gly Met Glu 
            980                 985                 990         


Gly Pro Pro Gly Thr Glu Gly Glu  Ser Gly Leu Gln Gly  Glu Pro Gly 
        995                 1000                 1005             


Ala Lys  Gly Asp Val Gly Thr  Ala Gly Ser Val Gly  Gly Thr Gly 
    1010                 1015                 1020             


Glu Pro  Gly Leu Arg Gly Glu  Pro Gly Ala Pro Gly  Glu Glu Gly 
    1025                 1030                 1035             


Leu Gln  Gly Lys Asp Gly Leu  Lys Gly Val Pro Gly  Gly Arg Gly 
    1040                 1045                 1050             


Leu Pro  Gly Glu Asp Gly Glu  Lys Gly Glu Met Gly  Leu Pro Gly 
    1055                 1060                 1065             


Ile Ile  Gly Pro Leu Gly Arg  Ser Gly Gln Thr Gly  Leu Pro Gly 
    1070                 1075                 1080             


Pro Glu  Gly Ile Val Gly Ile  Pro Gly Gln Arg Gly  Arg Pro Gly 
    1085                 1090                 1095             


Lys Lys  Gly Asp Lys Gly Gln  Ile Gly Pro Thr Gly  Glu Val Gly 
    1100                 1105                 1110             


Ser Arg  Gly Pro Pro Gly Lys  Ile Gly Lys Ser Gly  Pro Lys Gly 
    1115                 1120                 1125             


Ala Arg  Gly Thr Arg Gly Ala  Val Gly His Leu Gly  Leu Met Gly 
    1130                 1135                 1140             


Pro Asp  Gly Glu Pro Gly Ile  Pro Gly Tyr Arg Gly  His Gln Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Ser Gly Leu  Pro Gly Pro Lys Gly  Glu Lys Gly 
    1160                 1165                 1170             


Tyr Pro  Gly Glu Asp Ser Thr  Val Leu Gly Pro Pro  Gly Pro Arg 
    1175                 1180                 1185             


Gly Glu  Pro Gly Pro Val Gly  Asp Gln Gly Glu Arg  Gly Glu Pro 
    1190                 1195                 1200             


Gly Ala  Glu Gly Tyr Lys Gly  His Val Gly Val Pro  Gly Leu Arg 
    1205                 1210                 1215             


Gly Ala  Thr Gly Gln Gln Gly  Pro Pro Gly Glu Pro  Gly Asp Gln 
    1220                 1225                 1230             


Gly Glu  Gln Gly Leu Lys Gly  Glu Arg Gly Ser Glu  Gly Asn Lys 
    1235                 1240                 1245             


Gly Lys  Lys Gly Ala Pro Gly  Pro Ser Gly Lys Pro  Gly Ile Pro 
    1250                 1255                 1260             


Gly Leu  Gln Gly Leu Leu Gly  Pro Lys Gly Ile Gln  Gly Tyr His 
    1265                 1270                 1275             


Gly Ala  Asp Gly Ile Ser Gly  Asn Pro Gly Lys Ile  Gly Pro Pro 
    1280                 1285                 1290             


Gly Lys  Gln Gly Leu Pro Gly  Ile Arg Gly Gly Pro  Gly Arg Thr 
    1295                 1300                 1305             


Gly Leu  Ala Gly Ala Pro Gly  Pro Pro Gly Val Lys  Gly Ser Ser 
    1310                 1315                 1320             


Gly Leu  Pro Gly Ser Pro Gly  Ile Gln Gly Pro Lys  Gly Glu Gln 
    1325                 1330                 1335             


Gly Leu  Pro Gly Gln Pro Gly  Ile Gln Gly Lys Arg  Gly His Arg 
    1340                 1345                 1350             


Gly Ala  Gln Gly Asp Gln Gly  Pro Cys Gly Asp Pro  Gly Leu Lys 
    1355                 1360                 1365             


Gly Gln  Pro Gly Glu Tyr Gly  Val Gln Gly Leu Thr  Gly Phe Gln 
    1370                 1375                 1380             


Gly Phe  Pro Gly Pro Lys Gly  Pro Glu Gly Asp Ala  Gly Ile Val 
    1385                 1390                 1395             


Gly Ile  Ser Gly Pro Lys Gly  Pro Ile Gly His Arg  Gly Asn Thr 
    1400                 1405                 1410             


Gly Pro  Leu Gly Arg Glu Gly  Ile Ile Gly Pro Thr  Gly Arg Thr 
    1415                 1420                 1425             


Gly Pro  Arg Gly Glu Lys Gly  Phe Arg Gly Glu Thr  Gly Pro Gln 
    1430                 1435                 1440             


Gly Pro  Arg Gly Gln Pro Gly  Pro Pro Gly Pro Pro  Gly Ala Pro 
    1445                 1450                 1455             


Gly Pro  Arg Lys Gln Met Asp  Ile Asn Ala Ala Ile  Gln Ala Leu 
    1460                 1465                 1470             


Ile Glu  Ser Asn Thr Ala Leu  Gln Met Glu Ser Tyr  Gln Asn Thr 
    1475                 1480                 1485             


Glu Val  Thr Leu Ile Asp His  Ser Glu Glu Ile Phe  Lys Thr Leu 
    1490                 1495                 1500             


Asn Tyr  Leu Ser Asn Leu Leu  His Ser Ile Lys Asn  Pro Leu Gly 
    1505                 1510                 1515             


Thr Arg  Asp Asn Pro Ala Arg  Ile Cys Lys Asp Leu  Leu Asn Cys 
    1520                 1525                 1530             


Glu Gln  Lys Val Ser Asp Gly  Lys Tyr Trp Ile Asp  Pro Asn Leu 
    1535                 1540                 1545             


Gly Cys  Pro Ser Asp Ala Ile  Glu Val Phe Cys Asn  Phe Ser Ala 
    1550                 1555                 1560             


Gly Gly  Gln Thr Cys Leu Pro  Pro Val Ser Val Thr  Lys Leu Glu 
    1565                 1570                 1575             


Phe Gly  Val Gly Lys Val Gln  Met Asn Phe Leu His  Leu Leu Ser 
    1580                 1585                 1590             


Ser Glu  Ala Thr His Ile Ile  Thr Ile His Cys Leu  Asn Thr Pro 
    1595                 1600                 1605             


Arg Trp  Thr Ser Thr Gln Thr  Ser Gly Pro Gly Leu  Pro Ile Gly 
    1610                 1615                 1620             


Phe Lys  Gly Trp Asn Gly Gln  Ile Phe Lys Val Asn  Thr Leu Leu 
    1625                 1630                 1635             


Glu Pro  Lys Val Leu Ser Asp  Asp Cys Lys Ile Gln  Asp Gly Ser 
    1640                 1645                 1650             


Trp His  Lys Ala Thr Phe Leu  Phe His Thr Gln Glu  Pro Asn Gln 
    1655                 1660                 1665             


Leu Pro  Val Ile Glu Val Gln  Lys Leu Pro His Leu  Lys Thr Glu 
    1670                 1675                 1680             


Arg Lys  Tyr Tyr Ile Asp Ser  Ser Ser Val Cys Phe  Leu 
    1685                 1690                 1695     


<210>  2410
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL25A1__Homo_sapiens__NP_001243003

<400>  2410

Met Leu Leu Lys Lys His Ala Gly Lys Gly Gly Gly Arg Glu Pro Arg 
1               5                   10                  15      


Ser Glu Asp Pro Thr Pro Ala Glu Gln His Cys Ala Arg Thr Met Pro 
            20                  25                  30          


Pro Cys Ala Val Leu Ala Ala Leu Leu Ser Val Val Ala Val Val Ser 
        35                  40                  45              


Cys Leu Tyr Leu Gly Val Lys Thr Asn Asp Leu Gln Ala Arg Ile Ala 
    50                  55                  60                  


Ala Leu Glu Ser Ala Lys Gly Ala Pro Ser Ile His Leu Leu Pro Asp 
65                  70                  75                  80  


Thr Leu Asp His Leu Lys Thr Met Val Gln Glu Lys Val Glu Arg Leu 
                85                  90                  95      


Leu Ala Gln Lys Ser Tyr Glu His Met Ala Lys Ile Arg Ile Ala Arg 
            100                 105                 110         


Glu Ala Pro Ser Glu Cys Asn Cys Pro Ala Gly Pro Pro Gly Lys Arg 
        115                 120                 125             


Gly Lys Arg Gly Arg Arg Gly Glu Ser Gly Pro Pro Gly Gln Pro Gly 
    130                 135                 140                 


Pro Gln Gly Pro Pro Gly Pro Lys Gly Asp Lys Gly Glu Gln Gly Asp 
145                 150                 155                 160 


Gln Gly Pro Arg Gly Leu Pro Gly Phe Pro Thr Val Ala Ala Leu His 
                165                 170                 175     


Ser Asn Gln Ile Leu Thr Val Lys Gly Asp Gln Gly Gln Ala Gly Pro 
            180                 185                 190         


Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Asp Thr 
        195                 200                 205             


Gly Lys Asp Gly Pro Arg Gly Met Pro Gly Val Pro Gly Glu Pro Gly 
    210                 215                 220                 


Lys Pro Gly Glu Gln Gly Leu Met Gly Pro Leu Gly Pro Pro Gly Gln 
225                 230                 235                 240 


Lys Gly Ser Ile Gly Ala Pro Gly Ile Pro Gly Met Asn Gly Gln Lys 
                245                 250                 255     


Gly Glu Pro Gly Leu Pro Gly Ala Val Gly Gln Asn Gly Ile Pro Gly 
            260                 265                 270         


Pro Lys Gly Glu Pro Gly Glu Gln Gly Glu Lys Gly Asp Ala Gly Glu 
        275                 280                 285             


Asn Gly Pro Lys Gly Asp Thr Gly Glu Lys Gly Asp Pro Gly Ser Ser 
    290                 295                 300                 


Ala Ala Gly Ile Lys Gly Glu Pro Gly Glu Ser Gly Arg Pro Gly Gln 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Ile Lys 
                325                 330                 335     


Gly Glu Pro Gly Phe Ile Gly Pro Gln Gly Glu Pro Gly Leu Pro Gly 
            340                 345                 350         


Leu Pro Gly Thr Lys Gly Glu Arg Gly Glu Ala Gly Pro Pro Gly Arg 
        355                 360                 365             


Gly Glu Arg Gly Glu Pro Gly Ala Pro Gly Pro Lys Gly Asp Arg Gly 
    370                 375                 380                 


Glu Lys Gly Asp Ser Gly Ala Gln Gly Pro Arg Gly Pro Pro Gly Gln 
385                 390                 395                 400 


Lys Gly Asp Gln Gly Ala Thr Glu Ile Ile Asp Tyr Asn Gly Asn Leu 
                405                 410                 415     


His Glu Ala Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Leu 
            420                 425                 430         


Gln Gly Pro Lys Gly Glu Gln Gly Ser Pro Gly Ile Pro Gly Met Asp 
        435                 440                 445             


Gly Glu Gln Gly Leu Lys Gly Ser Lys Gly Asp Met Gly Asp Pro Gly 
    450                 455                 460                 


Met Thr Gly Glu Lys Gly Gly Ile Gly Leu Pro Gly Leu Pro Gly Ala 
465                 470                 475                 480 


Asn Gly Met Lys Gly Glu Lys Gly Asp Ser Gly Met Pro Gly Pro Gln 
                485                 490                 495     


Gly Pro Ser Ile Ile Gly Pro Pro Gly Pro Pro Gly Pro His Gly Pro 
            500                 505                 510         


Pro Gly Pro Met Gly Pro His Gly Leu Pro Gly Pro Lys Gly Glu Pro 
        515                 520                 525             


Gly Leu Asn Gly Val Lys Gly Leu Lys Gly Glu Pro Gly Gln Lys Gly 
    530                 535                 540                 


Asp Arg Gly Pro Leu Gly Leu Pro Gly Ala Ser Gly Leu Asp Gly Lys 
545                 550                 555                 560 


Pro Gly Ser Arg Gly Thr Asp Gly Pro Met Gly Pro His Gly Pro Ala 
                565                 570                 575     


Gly Pro Lys Gly Glu Arg Gly Glu Lys Gly Ala Met Gly Glu Pro Gly 
            580                 585                 590         


Pro Arg Gly Pro Tyr Gly Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu 
        595                 600                 605             


Lys Gly Asp Leu Gly Glu Lys Gly Glu Lys Val Thr Ser Pro Ser Gln 
    610                 615                 620                 


His Val Pro Cys Leu Ile Leu Leu Leu Leu Ser Ala Leu Leu Phe Ser 
625                 630                 635                 640 


Leu Cys Asp Ser Ile 
                645 


<210>  2411
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL26A1__Homo_sapiens__NP_001265492

<400>  2411

Met Lys Leu Ala Leu Leu Leu Pro Trp Ala Cys Cys Cys Leu Cys Gly 
1               5                   10                  15      


Ser Ala Leu Ala Thr Gly Phe Leu Tyr Pro Phe Ser Ala Ala Ala Leu 
            20                  25                  30          


Gln Gln His Gly Tyr Pro Glu Pro Gly Ala Gly Ser Pro Gly Ser Gly 
        35                  40                  45              


Tyr Ala Ser Arg Arg His Trp Cys His His Thr Val Thr Arg Thr Val 
    50                  55                  60                  


Ser Cys Gln Val Gln Asn Gly Ser Glu Thr Val Val Gln Arg Val Tyr 
65                  70                  75                  80  


Gln Ser Cys Arg Trp Pro Gly Pro Cys Ala Asn Leu Val Ser Tyr Arg 
                85                  90                  95      


Thr Leu Ile Arg Pro Thr Tyr Arg Val Ser Tyr Arg Thr Val Thr Val 
            100                 105                 110         


Leu Glu Trp Arg Cys Cys Pro Gly Phe Thr Gly Ser Asn Cys Asp Glu 
        115                 120                 125             


Glu Cys Met Asn Cys Thr Arg Leu Ser Asp Met Ser Glu Arg Leu Thr 
    130                 135                 140                 


Thr Leu Glu Ala Lys Val Leu Leu Leu Glu Ala Ala Glu Arg Pro Ser 
145                 150                 155                 160 


Ser Pro Asp Asn Asp Leu Pro Ala Pro Glu Ser Thr Pro Pro Thr Trp 
                165                 170                 175     


Asn Glu Asp Phe Leu Pro Asp Ala Ile Pro Leu Ala His Pro Val Pro 
            180                 185                 190         


Arg Gln Arg Arg Pro Thr Gly Pro Ala Gly Pro Pro Gly Gln Thr Gly 
        195                 200                 205             


Pro Pro Gly Pro Ala Gly Pro Pro Gly Ser Lys Gly Asp Arg Gly Gln 
    210                 215                 220                 


Thr Gly Glu Lys Gly Pro Ala Gly Pro Pro Gly Leu Leu Gly Pro Pro 
225                 230                 235                 240 


Gly Pro Arg Gly Leu Pro Gly Glu Met Gly Arg Pro Gly Pro Pro Gly 
                245                 250                 255     


Pro Pro Gly Pro Ala Gly Asn Pro Gly Pro Ser Pro Asn Ser Pro Gln 
            260                 265                 270         


Gly Ala Leu Tyr Ser Leu Gln Pro Pro Thr Asp Lys Asp Asn Gly Asp 
        275                 280                 285             


Ser Arg Leu Ala Ser Ala Ile Val Asp Thr Val Leu Ala Gly Val Pro 
    290                 295                 300                 


Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
305                 310                 315                 320 


Pro Pro Gly Pro Pro Gly Thr Pro Gly Ser Gln Gly Leu Ala Gly Glu 
                325                 330                 335     


Arg Gly Thr Val Gly Pro Ser Gly Glu Pro Gly Val Lys Gly Glu Glu 
            340                 345                 350         


Gly Glu Lys Ala Ala Thr Ala Glu Gly Glu Gly Val Gln Gln Leu Arg 
        355                 360                 365             


Glu Ala Leu Lys Ile Leu Ala Glu Arg Val Leu Ile Leu Glu His Met 
    370                 375                 380                 


Ile Gly Ile His Asp Pro Leu Ala Ser Pro Glu Gly Gly Ser Gly Gln 
385                 390                 395                 400 


Asp Ala Ala Leu Arg Ala Asn Leu Lys Met Lys Arg Gly Gly Ala Gln 
                405                 410                 415     


Pro Asp Gly Val Leu Ala Ala Leu Leu Gly Pro Asp Pro Gly Gln Lys 
            420                 425                 430         


Ser Val Asp Gln Ala Ser Ser Arg Lys 
        435                 440     


<210>  2412
<211>  1860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL27A1__Homo_sapiens__NP_116277

<400>  2412

Met Gly Ala Gly Ser Ala Arg Gly Ala Arg Gly Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Arg Gly Gly Gly Phe Leu Phe Ser Trp Ile Leu Val Ser Phe 
            20                  25                  30          


Ala Cys His Leu Ala Ser Thr Gln Gly Ala Pro Glu Asp Val Asp Ile 
        35                  40                  45              


Leu Gln Arg Leu Gly Leu Ser Trp Thr Lys Ala Gly Ser Pro Ala Pro 
    50                  55                  60                  


Pro Gly Val Ile Pro Phe Gln Ser Gly Phe Ile Phe Thr Gln Arg Ala 
65                  70                  75                  80  


Arg Leu Gln Ala Pro Thr Gly Thr Val Ile Pro Ala Ala Leu Gly Thr 
                85                  90                  95      


Glu Leu Ala Leu Val Leu Ser Leu Cys Ser His Arg Val Asn His Ala 
            100                 105                 110         


Phe Leu Phe Ala Val Arg Ser Gln Lys Arg Lys Leu Gln Leu Gly Leu 
        115                 120                 125             


Gln Phe Leu Pro Gly Lys Thr Val Val His Leu Gly Ser Arg Arg Ser 
    130                 135                 140                 


Val Ala Phe Asp Leu Asp Met His Asp Gly Arg Trp His His Leu Ala 
145                 150                 155                 160 


Leu Glu Leu Arg Gly Arg Thr Val Thr Leu Val Thr Ala Cys Gly Gln 
                165                 170                 175     


Arg Arg Val Pro Val Leu Leu Pro Phe His Arg Asp Pro Ala Leu Asp 
            180                 185                 190         


Pro Gly Gly Ser Phe Leu Phe Gly Lys Met Asn Pro His Ala Val Gln 
        195                 200                 205             


Phe Glu Gly Ala Leu Cys Gln Phe Ser Ile Tyr Pro Val Thr Gln Val 
    210                 215                 220                 


Ala His Asn Tyr Cys Thr His Leu Arg Lys Gln Cys Gly Gln Ala Asp 
225                 230                 235                 240 


Thr Tyr Gln Ser Pro Leu Gly Pro Leu Phe Ser Gln Asp Ser Gly Arg 
                245                 250                 255     


Pro Phe Thr Phe Gln Ser Asp Leu Ala Leu Leu Gly Leu Glu Asn Leu 
            260                 265                 270         


Thr Thr Ala Thr Pro Ala Leu Gly Ser Leu Pro Ala Gly Arg Gly Pro 
        275                 280                 285             


Arg Gly Thr Val Ala Pro Ala Thr Pro Thr Lys Pro Gln Arg Thr Ser 
    290                 295                 300                 


Pro Thr Asn Pro His Gln His Met Ala Val Gly Gly Pro Ala Gln Thr 
305                 310                 315                 320 


Pro Leu Leu Pro Ala Lys Leu Ser Ala Ser Asn Ala Leu Asp Pro Met 
                325                 330                 335     


Leu Pro Ala Ser Val Gly Gly Ser Thr Arg Thr Pro Arg Pro Ala Ala 
            340                 345                 350         


Ala Gln Pro Ser Gln Lys Ile Thr Ala Thr Lys Ile Pro Lys Ser Leu 
        355                 360                 365             


Pro Thr Lys Pro Ser Ala Pro Ser Thr Ser Ile Val Pro Ile Lys Ser 
    370                 375                 380                 


Pro His Pro Thr Gln Lys Thr Ala Pro Ser Ser Phe Thr Lys Ser Ala 
385                 390                 395                 400 


Leu Pro Thr Gln Lys Gln Val Pro Pro Thr Ser Arg Pro Val Pro Ala 
                405                 410                 415     


Arg Val Ser Arg Pro Ala Glu Lys Pro Ile Gln Arg Asn Pro Gly Met 
            420                 425                 430         


Pro Arg Pro Pro Pro Pro Ser Thr Arg Pro Leu Pro Pro Thr Thr Ser 
        435                 440                 445             


Ser Ser Lys Lys Pro Ile Pro Thr Leu Ala Arg Thr Glu Ala Lys Ile 
    450                 455                 460                 


Thr Ser His Ala Ser Lys Pro Ala Ser Ala Arg Thr Ser Thr His Lys 
465                 470                 475                 480 


Pro Pro Pro Phe Thr Ala Leu Ser Ser Ser Pro Ala Pro Thr Pro Gly 
                485                 490                 495     


Ser Thr Arg Ser Thr Arg Pro Pro Ala Thr Met Val Pro Pro Thr Ser 
            500                 505                 510         


Gly Thr Ser Thr Pro Arg Thr Ala Pro Ala Val Pro Thr Pro Gly Ser 
        515                 520                 525             


Ala Pro Thr Gly Ser Lys Lys Pro Ile Gly Ser Glu Ala Ser Lys Lys 
    530                 535                 540                 


Ala Gly Pro Lys Ser Ser Pro Arg Lys Pro Val Pro Leu Arg Pro Gly 
545                 550                 555                 560 


Lys Ala Ala Arg Asp Val Pro Leu Ser Asp Leu Thr Thr Arg Pro Ser 
                565                 570                 575     


Pro Arg Gln Pro Gln Pro Ser Gln Gln Thr Thr Pro Ala Leu Val Leu 
            580                 585                 590         


Ala Pro Ala Gln Phe Leu Ser Ser Ser Pro Arg Pro Thr Ser Ser Gly 
        595                 600                 605             


Tyr Ser Ile Phe His Leu Ala Gly Ser Thr Pro Phe Pro Leu Leu Met 
    610                 615                 620                 


Gly Pro Pro Gly Pro Lys Gly Asp Cys Gly Leu Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Leu Pro Gly Leu Pro Gly Ile Pro Gly Ala Arg Gly Pro Arg Gly Pro 
                645                 650                 655     


Pro Gly Pro Tyr Gly Asn Pro Gly Leu Pro Gly Pro Pro Gly Ala Lys 
            660                 665                 670         


Gly Gln Lys Gly Asp Pro Gly Leu Ser Pro Gly Lys Ala His Asp Gly 
        675                 680                 685             


Ala Lys Gly Asp Met Gly Leu Pro Gly Leu Ser Gly Asn Pro Gly Pro 
    690                 695                 700                 


Pro Gly Arg Lys Gly His Lys Gly Tyr Pro Gly Pro Ala Gly His Pro 
705                 710                 715                 720 


Gly Glu Gln Gly Gln Pro Gly Pro Glu Gly Ser Pro Gly Ala Lys Gly 
                725                 730                 735     


Tyr Pro Gly Arg Gln Gly Leu Pro Gly Pro Val Gly Asp Pro Gly Pro 
            740                 745                 750         


Lys Gly Ser Arg Gly Tyr Ile Gly Leu Pro Gly Leu Phe Gly Leu Pro 
        755                 760                 765             


Gly Ser Asp Gly Glu Arg Gly Leu Pro Gly Val Pro Gly Lys Arg Gly 
    770                 775                 780                 


Lys Met Gly Met Pro Gly Phe Pro Gly Val Phe Gly Glu Arg Gly Pro 
785                 790                 795                 800 


Pro Gly Leu Asp Gly Asn Pro Gly Glu Leu Gly Leu Pro Gly Pro Pro 
                805                 810                 815     


Gly Val Pro Gly Leu Ile Gly Asp Leu Gly Val Leu Gly Pro Ile Gly 
            820                 825                 830         


Tyr Pro Gly Pro Lys Gly Met Lys Gly Leu Met Gly Ser Val Gly Glu 
        835                 840                 845             


Pro Gly Leu Lys Gly Asp Lys Gly Glu Gln Gly Val Pro Gly Val Ser 
    850                 855                 860                 


Gly Asp Pro Gly Phe Gln Gly Asp Lys Gly Ser Gln Gly Leu Pro Gly 
865                 870                 875                 880 


Phe Pro Gly Ala Arg Gly Lys Pro Gly Pro Leu Gly Lys Val Gly Asp 
                885                 890                 895     


Lys Gly Ser Ile Gly Phe Pro Gly Pro Pro Gly Pro Glu Gly Phe Pro 
            900                 905                 910         


Gly Asp Ile Gly Pro Pro Gly Asp Asn Gly Pro Glu Gly Met Lys Gly 
        915                 920                 925             


Lys Pro Gly Ala Arg Gly Leu Pro Gly Pro Arg Gly Gln Leu Gly Pro 
    930                 935                 940                 


Glu Gly Asp Glu Gly Pro Met Gly Pro Pro Gly Ala Pro Gly Leu Glu 
945                 950                 955                 960 


Gly Gln Pro Gly Arg Lys Gly Phe Pro Gly Arg Pro Gly Leu Asp Gly 
                965                 970                 975     


Val Lys Gly Glu Pro Gly Asp Pro Gly Arg Pro Gly Pro Val Gly Glu 
            980                 985                 990         


Gln Gly Phe Met Gly Phe Ile Gly  Leu Val Gly Glu Pro  Gly Ile Val 
        995                 1000                 1005             


Gly Glu  Lys Gly Asp Arg Gly  Met Met Gly Pro Pro  Gly Val Pro 
    1010                 1015                 1020             


Gly Pro  Lys Gly Ser Met Gly  His Pro Gly Met Pro  Gly Gly Met 
    1025                 1030                 1035             


Gly Thr  Pro Gly Glu Pro Gly  Pro Gln Gly Pro Pro  Gly Ser Arg 
    1040                 1045                 1050             


Gly Pro  Pro Gly Met Arg Gly  Ala Lys Gly Arg Arg  Gly Pro Arg 
    1055                 1060                 1065             


Gly Pro  Asp Gly Pro Ala Gly  Glu Gln Gly Ser Arg  Gly Leu Lys 
    1070                 1075                 1080             


Gly Pro  Pro Gly Pro Gln Gly  Arg Pro Gly Arg Pro  Gly Gln Gln 
    1085                 1090                 1095             


Gly Val  Ala Gly Glu Arg Gly  His Leu Gly Ser Arg  Gly Phe Pro 
    1100                 1105                 1110             


Gly Ile  Pro Gly Pro Ser Gly  Pro Pro Gly Thr Lys  Gly Leu Pro 
    1115                 1120                 1125             


Gly Glu  Pro Gly Pro Gln Gly  Pro Gln Gly Pro Ile  Gly Pro Pro 
    1130                 1135                 1140             


Gly Glu  Met Gly Pro Lys Gly  Pro Pro Gly Ala Val  Gly Glu Pro 
    1145                 1150                 1155             


Gly Leu  Pro Gly Glu Ala Gly  Met Lys Gly Asp Leu  Gly Pro Leu 
    1160                 1165                 1170             


Gly Thr  Pro Gly Glu Gln Gly  Leu Ile Gly Gln Arg  Gly Glu Pro 
    1175                 1180                 1185             


Gly Leu  Glu Gly Asp Ser Gly  Pro Met Gly Pro Asp  Gly Leu Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Asp Pro Gly  Pro Asp Gly Glu His  Gly Glu Lys 
    1205                 1210                 1215             


Gly Gln  Glu Gly Leu Met Gly  Glu Asp Gly Pro Pro  Gly Pro Pro 
    1220                 1225                 1230             


Gly Val  Thr Gly Val Arg Gly  Pro Glu Gly Lys Ser  Gly Lys Gln 
    1235                 1240                 1245             


Gly Glu  Lys Gly Arg Thr Gly  Ala Lys Gly Ala Lys  Gly Tyr Gln 
    1250                 1255                 1260             


Gly Gln  Leu Gly Glu Met Gly  Val Pro Gly Asp Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Thr  Pro Gly Pro Lys Gly  Ser Arg Gly Ser Leu  Gly Pro Thr 
    1280                 1285                 1290             


Gly Ala  Pro Gly Arg Met Gly  Ala Gln Gly Glu Pro  Gly Leu Ala 
    1295                 1300                 1305             


Gly Tyr  Asp Gly His Lys Gly  Ile Val Gly Pro Leu  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Glu Lys Gly  Glu Gln Gly Glu Asp  Gly Lys Ala 
    1325                 1330                 1335             


Glu Gly  Pro Pro Gly Pro Pro  Gly Asp Arg Gly Pro  Val Gly Asp 
    1340                 1345                 1350             


Arg Gly  Asp Arg Gly Glu Pro  Gly Asp Pro Gly Tyr  Pro Gly Gln 
    1355                 1360                 1365             


Glu Gly  Val Gln Gly Leu Arg  Gly Lys Pro Gly Gln  Gln Gly Gln 
    1370                 1375                 1380             


Pro Gly  His Pro Gly Pro Arg  Gly Trp Pro Gly Pro  Lys Gly Ser 
    1385                 1390                 1395             


Lys Gly  Ala Glu Gly Pro Lys  Gly Lys Gln Gly Lys  Ala Gly Ala 
    1400                 1405                 1410             


Pro Gly  Arg Arg Gly Val Gln  Gly Leu Gln Gly Leu  Pro Gly Pro 
    1415                 1420                 1425             


Arg Gly  Val Val Gly Arg Gln  Gly Leu Glu Gly Ile  Ala Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Pro Gly Arg Asp  Gly Gln Ala Gly Gln  Gln Gly Glu 
    1445                 1450                 1455             


Gln Gly  Asp Asp Gly Asp Pro  Gly Pro Met Gly Pro  Ala Gly Lys 
    1460                 1465                 1470             


Arg Gly  Asn Pro Gly Val Ala  Gly Leu Pro Gly Ala  Gln Gly Pro 
    1475                 1480                 1485             


Pro Gly  Phe Lys Gly Glu Ser  Gly Leu Pro Gly Gln  Leu Gly Pro 
    1490                 1495                 1500             


Pro Gly  Lys Arg Gly Thr Glu  Gly Arg Thr Gly Leu  Pro Gly Asn 
    1505                 1510                 1515             


Gln Gly  Glu Pro Gly Ser Lys  Gly Gln Pro Gly Asp  Ser Gly Glu 
    1520                 1525                 1530             


Met Gly  Phe Pro Gly Met Ala  Gly Leu Phe Gly Pro  Lys Gly Pro 
    1535                 1540                 1545             


Pro Gly  Asp Ile Gly Phe Lys  Gly Ile Gln Gly Pro  Arg Gly Pro 
    1550                 1555                 1560             


Pro Gly  Leu Met Gly Lys Glu  Gly Ile Val Gly Pro  Leu Gly Ile 
    1565                 1570                 1575             


Leu Gly  Pro Ser Gly Leu Pro  Gly Pro Lys Gly Asp  Lys Gly Ser 
    1580                 1585                 1590             


Arg Gly  Asp Trp Gly Leu Gln  Gly Pro Arg Gly Pro  Pro Gly Pro 
    1595                 1600                 1605             


Arg Gly  Arg Pro Gly Pro Pro  Gly Pro Pro Gly Gly  Pro Ile Gln 
    1610                 1615                 1620             


Leu Gln  Gln Asp Asp Leu Gly  Ala Ala Phe Gln Thr  Trp Met Asp 
    1625                 1630                 1635             


Thr Ser  Gly Ala Leu Arg Pro  Glu Ser Tyr Ser Tyr  Pro Asp Arg 
    1640                 1645                 1650             


Leu Val  Leu Asp Gln Gly Gly  Glu Ile Phe Lys Thr  Leu His Tyr 
    1655                 1660                 1665             


Leu Ser  Asn Leu Ile Gln Ser  Ile Lys Thr Pro Leu  Gly Thr Lys 
    1670                 1675                 1680             


Glu Asn  Pro Ala Arg Val Cys  Arg Asp Leu Met Asp  Cys Glu Gln 
    1685                 1690                 1695             


Lys Met  Val Asp Gly Thr Tyr  Trp Val Asp Pro Asn  Leu Gly Cys 
    1700                 1705                 1710             


Ser Ser  Asp Thr Ile Glu Val  Ser Cys Asn Phe Thr  His Gly Gly 
    1715                 1720                 1725             


Gln Thr  Cys Leu Lys Pro Ile  Thr Ala Ser Lys Val  Glu Phe Ala 
    1730                 1735                 1740             


Ile Ser  Arg Val Gln Met Asn  Phe Leu His Leu Leu  Ser Ser Glu 
    1745                 1750                 1755             


Val Thr  Gln His Ile Thr Ile  His Cys Leu Asn Met  Thr Val Trp 
    1760                 1765                 1770             


Gln Glu  Gly Thr Gly Gln Thr  Pro Ala Lys Gln Ala  Val Arg Phe 
    1775                 1780                 1785             


Arg Ala  Trp Asn Gly Gln Ile  Phe Glu Ala Gly Gly  Gln Phe Arg 
    1790                 1795                 1800             


Pro Glu  Val Ser Met Asp Gly  Cys Lys Val Gln Asp  Gly Arg Trp 
    1805                 1810                 1815             


His Gln  Thr Leu Phe Thr Phe  Arg Thr Gln Asp Pro  Gln Gln Leu 
    1820                 1825                 1830             


Pro Ile  Ile Ser Val Asp Asn  Leu Pro Pro Ala Ser  Ser Gly Lys 
    1835                 1840                 1845             


Gln Tyr  Arg Leu Glu Val Gly  Pro Ala Cys Phe Leu  
    1850                 1855                 1860 


<210>  2413
<211>  1125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL28A1__Homo_sapiens__XP_011513662

<400>  2413

Met Trp Asn Arg Tyr Phe Val Phe Tyr Leu Leu Leu Leu Ser Ala Phe 
1               5                   10                  15      


Thr Ser Gln Thr Val Ser Gly Gln Arg Lys Lys Gly Pro Lys Ser Asn 
            20                  25                  30          


Leu Leu Ala Arg Lys Ser Asp Val Gln Gly Ser Ile Cys Phe Ile Asp 
        35                  40                  45              


Ile Val Phe Ile Val Asp Ser Ser Glu Ser Ser Lys Ile Ala Leu Phe 
    50                  55                  60                  


Asp Lys Gln Lys Asp Phe Val Asp Ser Leu Ser Asp Lys Ile Phe Gln 
65                  70                  75                  80  


Leu Thr Pro Gly Arg Ser Leu Glu Tyr Asp Ile Lys Leu Ala Ala Leu 
                85                  90                  95      


Gln Phe Ser Ser Ser Val Gln Ile Asp Pro Pro Phe Ser Ser Trp Lys 
            100                 105                 110         


Asp Leu Gln Thr Phe Lys Gln Lys Val Lys Ser Met Asn Leu Ile Gly 
        115                 120                 125             


Gln Gly Thr Phe Ser Tyr Tyr Ala Ile Ser Asn Ala Thr Arg Leu Leu 
    130                 135                 140                 


Lys Arg Glu Gly Arg Lys Asp Gly Val Lys Val Val Leu Leu Met Thr 
145                 150                 155                 160 


Asp Gly Ile Asp His Pro Lys Asn Pro Asp Val Gln Ser Ile Ser Glu 
                165                 170                 175     


Asp Ala Arg Ile Ser Gly Ile Ser Phe Ile Thr Ile Ala Leu Ser Thr 
            180                 185                 190         


Val Val Asn Glu Ala Lys Leu Arg Leu Ile Ser Gly Asp Ser Ser Ser 
        195                 200                 205             


Glu Pro Thr Leu Leu Leu Ser Asp Pro Thr Leu Val Asp Lys Ile Gln 
    210                 215                 220                 


Asp Arg Leu Asp Ile Leu Phe Glu Lys Lys Cys Glu Arg Lys Ile Cys 
225                 230                 235                 240 


Glu Cys Glu Lys Gly Asp Pro Gly Asp Pro Gly Pro Pro Gly Thr His 
                245                 250                 255     


Gly Asn Pro Gly Ile Lys Gly Glu Arg Gly Pro Lys Gly Asn Pro Gly 
            260                 265                 270         


Asn Ala Gln Lys Gly Glu Ala Gly Glu Arg Gly Pro Gly Gly Ile Pro 
        275                 280                 285             


Gly Tyr Lys Gly Asp Lys Gly Glu Arg Gly Glu Cys Gly Lys Pro Gly 
    290                 295                 300                 


Ile Lys Gly Asp Lys Gly Ser Pro Gly Pro Tyr Gly Pro Lys Gly Pro 
305                 310                 315                 320 


Arg Gly Ile Gln Gly Ile Thr Gly Pro Pro Gly Asp Pro Gly Pro Lys 
                325                 330                 335     


Gly Phe Gln Gly Asn Lys Gly Glu Pro Gly Pro Pro Gly Pro Tyr Gly 
            340                 345                 350         


Ser Pro Gly Ala Pro Gly Ile Gly Gln Gln Gly Ile Lys Gly Glu Arg 
        355                 360                 365             


Gly Gln Glu Gly Arg Pro Gly Ala Pro Gly Pro Ile Gly Val Gly Glu 
    370                 375                 380                 


Pro Gly Gln Pro Gly Pro Arg Gly Pro Glu Gly Val Pro Gly Glu Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Gly Phe Pro Gly Pro Lys Gly Glu Lys Gly Ser 
                405                 410                 415     


Glu Gly Pro Thr Gly Pro Gln Gly Leu Gln Gly Leu Ser Ile Lys Gly 
            420                 425                 430         


Glu Lys Gly Asp Ile Gly Pro Val Gly Pro Gln Gly Pro Met Gly Ile 
        435                 440                 445             


Pro Gly Ile Gly Ser Gln Gly Glu Gln Gly Ile Gln Gly Pro Ile Gly 
    450                 455                 460                 


Pro Pro Gly Pro Gln Gly Pro Ala Gly Gln Gly Leu Pro Gly Ser Lys 
465                 470                 475                 480 


Gly Glu Val Gly Gln Met Gly Pro Thr Gly Pro Arg Gly Pro Val Gly 
                485                 490                 495     


Ile Gly Val Gln Gly Pro Lys Gly Glu Pro Gly Ser Ile Gly Leu Pro 
            500                 505                 510         


Gly Gln Pro Gly Val Pro Gly Glu Asp Gly Ala Ala Gly Lys Lys Gly 
        515                 520                 525             


Glu Ala Gly Leu Pro Gly Ala Arg Gly Pro Glu Gly Pro Pro Gly Lys 
    530                 535                 540                 


Gly Gln Pro Gly Pro Lys Gly Asp Glu Gly Lys Lys Gly Ser Lys Gly 
545                 550                 555                 560 


Asn Gln Gly Gln Arg Gly Leu Pro Gly Pro Glu Gly Pro Lys Gly Glu 
                565                 570                 575     


Pro Gly Ile Met Gly Pro Phe Gly Met Pro Gly Thr Ser Ile Pro Gly 
            580                 585                 590         


Pro Pro Gly Pro Lys Gly Asp Arg Gly Gly Pro Gly Ile Pro Gly Phe 
        595                 600                 605             


Lys Gly Glu Pro Gly Leu Ser Ile Arg Gly Pro Lys Gly Val Gln Gly 
    610                 615                 620                 


Pro Arg Gly Pro Val Gly Ala Pro Gly Leu Lys Gly Asp Gly Tyr Pro 
625                 630                 635                 640 


Gly Val Pro Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Met Gly 
                645                 650                 655     


Leu Arg Gly Val Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Val Arg 
            660                 665                 670         


Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Val Gly Thr Gln Gly Pro 
        675                 680                 685             


Lys Gly Asp Thr Gly Gln Lys Gly Leu Pro Gly Pro Pro Gly Pro Pro 
    690                 695                 700                 


Gly Tyr Gly Ser Gln Gly Ile Lys Gly Glu Gln Gly Pro Gln Gly Phe 
705                 710                 715                 720 


Pro Gly Pro Lys Gly Thr Met Gly His Gly Leu Pro Gly Gln Lys Gly 
                725                 730                 735     


Glu His Gly Glu Arg Gly Asp Val Gly Lys Lys Gly Asp Lys Gly Glu 
            740                 745                 750         


Ile Gly Glu Pro Gly Ser Pro Gly Lys Gln Gly Leu Gln Gly Pro Lys 
        755                 760                 765             


Gly Asp Leu Gly Leu Thr Lys Glu Glu Ile Ile Lys Leu Ile Thr Glu 
    770                 775                 780                 


Ile Cys Gly Cys Gly Pro Lys Cys Lys Glu Thr Pro Leu Glu Leu Val 
785                 790                 795                 800 


Phe Val Ile Asp Ser Ser Glu Ser Val Gly Pro Glu Asn Phe Gln Ile 
                805                 810                 815     


Ile Lys Asn Phe Val Lys Thr Met Ala Asp Arg Val Ala Leu Asp Leu 
            820                 825                 830         


Ala Thr Ala Arg Ile Gly Ile Ile Asn Tyr Ser His Lys Val Glu Lys 
        835                 840                 845             


Val Ala Asn Leu Lys Gln Phe Ser Ser Lys Asp Asp Phe Lys Leu Ala 
    850                 855                 860                 


Val Asp Asn Met Gln Tyr Leu Gly Glu Gly Thr Tyr Thr Ala Thr Ala 
865                 870                 875                 880 


Leu Gln Ala Ala Asn Asp Met Phe Glu Asp Ala Arg Pro Gly Val Lys 
                885                 890                 895     


Lys Val Ala Leu Val Ile Thr Asp Gly Gln Thr Asp Ser Arg Asp Lys 
            900                 905                 910         


Glu Lys Leu Thr Glu Val Val Lys Asn Ala Ser Asp Thr Asn Val Glu 
        915                 920                 925             


Ile Phe Val Ile Gly Val Val Lys Lys Asn Asp Pro Asn Phe Glu Ile 
    930                 935                 940                 


Phe His Lys Glu Met Asn Leu Ile Ala Thr Asp Pro Glu His Val Tyr 
945                 950                 955                 960 


Gln Phe Asp Asp Phe Phe Thr Leu Gln Asp Thr Leu Lys Gln Lys Leu 
                965                 970                 975     


Phe Gln Lys Ile Cys Glu Asp Phe Asp Ser Tyr Leu Val Gln Ile Phe 
            980                 985                 990         


Gly Ser Ser Ser Pro Gln Pro Gly  Phe Gly Met Ser Gly  Glu Glu Leu 
        995                 1000                 1005             


Ser Glu  Ser Thr Pro Glu Pro  Gln Lys Glu Ile Ser  Glu Ser Leu 
    1010                 1015                 1020             


Ser Val  Thr Arg Asp Gln Asp  Glu Asp Asp Lys Ala  Pro Glu Pro 
    1025                 1030                 1035             


Thr Trp  Ala Asp Asp Leu Pro  Ala Thr Thr Ser Ser  Glu Ala Thr 
    1040                 1045                 1050             


Thr Thr  Pro Arg Pro Leu Leu  Ser Thr Pro Val Asp  Gly Ala Glu 
    1055                 1060                 1065             


Asp Pro  Arg Cys Leu Glu Ala  Leu Lys Pro Gly Asn  Cys Gly Glu 
    1070                 1075                 1080             


Tyr Val  Val Arg Trp Tyr Tyr  Asp Lys Gln Val Asn  Ser Cys Ala 
    1085                 1090                 1095             


Arg Phe  Trp Phe Ser Gly Cys  Asn Gly Ser Gly Asn  Arg Phe Asn 
    1100                 1105                 1110             


Ser Glu  Lys Glu Cys Gln Glu  Thr Cys Ile Gln Gly  
    1115                 1120                 1125 


<210>  2414
<211>  1487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL2A1__Homo_sapiens__NP_001835

<400>  2414

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210>  2415
<211>  1466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL3A1__Homo_sapiens__NP_000081

<400>  2415

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Thr Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Thr Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val Gln 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Ser  Lys Thr Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210>  2416
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL4A1__Homo_sapiens__NP_001290039

<400>  2416

Met Gly Pro Arg Leu Ser Val Trp Leu Leu Leu Leu Pro Ala Ala Leu 
1               5                   10                  15      


Leu Leu His Glu Glu His Ser Arg Ala Ala Ala Lys Gly Gly Cys Ala 
            20                  25                  30          


Gly Ser Gly Cys Gly Lys Cys Asp Cys His Gly Val Lys Gly Gln Lys 
        35                  40                  45              


Gly Glu Arg Gly Leu Pro Gly Leu Gln Gly Val Ile Gly Phe Pro Gly 
    50                  55                  60                  


Met Gln Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly Gln Lys Gly Asp 
65                  70                  75                  80  


Thr Gly Glu Pro Gly Leu Pro Gly Thr Lys Gly Thr Arg Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Gly Tyr Pro Gly Asn Pro Gly Leu Pro Gly Ile Pro Gly 
            100                 105                 110         


Gln Asp Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Cys Asn Gly Thr 
        115                 120                 125             


Lys Gly Glu Arg Gly Pro Leu Gly Pro Pro Gly Leu Pro Gly Phe Ala 
    130                 135                 140                 


Gly Asn Pro Gly Pro Pro Gly Leu Pro Gly Met Lys Gly Asp Pro Gly 
145                 150                 155                 160 


Glu Ile Leu Gly His Val Pro Gly Met Leu Leu Lys Gly Glu Arg Gly 
                165                 170                 175     


Phe Pro Gly Ile Pro Gly Thr Pro Gly Pro Pro Gly Leu Pro Gly Leu 
            180                 185                 190         


Gln Gly Pro Val Gly Pro Pro Gly Phe Thr Gly Pro Pro Gly Pro Pro 
        195                 200                 205             


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Gln Met Gly Leu Ser Phe 
    210                 215                 220                 


Gln Gly Pro Lys Gly Asp Lys Gly Asp Gln Gly Val Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Val Pro Gly Gln Ala Gln Val Gln Glu Lys Gly Asp Phe Ala Thr 
                245                 250                 255     


Lys Gly Glu Lys Gly Gln Lys Gly Glu Pro Gly Phe Gln Gly Met Pro 
            260                 265                 270         


Gly Val Gly Glu Lys Gly Glu Pro Gly Lys Pro Gly Pro Arg Gly Lys 
        275                 280                 285             


Pro Gly Lys Asp Gly Asp Lys Gly Glu Lys Gly Ser Pro Gly Phe Pro 
    290                 295                 300                 


Gly Glu Pro Gly Tyr Pro Gly Leu Ile Gly Arg Gln Gly Pro Gln Gly 
305                 310                 315                 320 


Glu Lys Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Ile Val Ile Gly 
                325                 330                 335     


Thr Gly Pro Leu Gly Glu Lys Gly Glu Arg Gly Tyr Pro Gly Thr Pro 
            340                 345                 350         


Gly Pro Arg Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Leu Pro Gly 
        355                 360                 365             


Gln Pro Gly Pro Pro Gly Leu Pro Val Pro Gly Gln Ala Gly Ala Pro 
    370                 375                 380                 


Gly Phe Pro Gly Glu Arg Gly Glu Lys Gly Asp Arg Gly Phe Pro Gly 
385                 390                 395                 400 


Thr Ser Leu Pro Gly Pro Ser Gly Arg Asp Gly Leu Pro Gly Pro Pro 
                405                 410                 415     


Gly Ser Pro Gly Pro Pro Gly Gln Pro Gly Tyr Thr Asn Gly Ile Val 
            420                 425                 430         


Glu Cys Gln Pro Gly Pro Pro Gly Asp Gln Gly Pro Pro Gly Ile Pro 
        435                 440                 445             


Gly Gln Pro Gly Phe Ile Gly Glu Ile Gly Glu Lys Gly Gln Lys Gly 
    450                 455                 460                 


Glu Ser Cys Leu Ile Cys Asp Ile Asp Gly Tyr Arg Gly Pro Pro Gly 
465                 470                 475                 480 


Pro Gln Gly Pro Pro Gly Glu Ile Gly Phe Pro Gly Gln Pro Gly Ala 
                485                 490                 495     


Lys Gly Asp Arg Gly Leu Pro Gly Arg Asp Gly Val Ala Gly Val Pro 
            500                 505                 510         


Leu Leu Phe Gln Ile His Lys 
        515                 


<210>  2417
<211>  1712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL4A2__Homo_sapiens__NP_001837

<400>  2417

Met Gly Arg Asp Gln Arg Ala Val Ala Gly Pro Ala Leu Arg Arg Trp 
1               5                   10                  15      


Leu Leu Leu Gly Thr Val Thr Val Gly Phe Leu Ala Gln Ser Val Leu 
            20                  25                  30          


Ala Gly Val Lys Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser 
        35                  40                  45              


Gly Gly Cys Gln Cys Tyr Pro Glu Lys Gly Gly Arg Gly Gln Pro Gly 
    50                  55                  60                  


Pro Val Gly Pro Gln Gly Tyr Asn Gly Pro Pro Gly Leu Gln Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Gln Gly Arg Lys Gly Asp Lys Gly Glu Arg Gly Ala Pro 
                85                  90                  95      


Gly Val Thr Gly Pro Lys Gly Asp Val Gly Ala Arg Gly Val Ser Gly 
            100                 105                 110         


Phe Pro Gly Ala Asp Gly Ile Pro Gly His Pro Gly Gln Gly Gly Pro 
        115                 120                 125             


Arg Gly Arg Pro Gly Tyr Asp Gly Cys Asn Gly Thr Gln Gly Asp Ser 
    130                 135                 140                 


Gly Pro Gln Gly Pro Pro Gly Ser Glu Gly Phe Thr Gly Pro Pro Gly 
145                 150                 155                 160 


Pro Gln Gly Pro Lys Gly Gln Lys Gly Glu Pro Tyr Ala Leu Pro Lys 
                165                 170                 175     


Glu Glu Arg Asp Arg Tyr Arg Gly Glu Pro Gly Glu Pro Gly Leu Val 
            180                 185                 190         


Gly Phe Gln Gly Pro Pro Gly Arg Pro Gly His Val Gly Gln Met Gly 
        195                 200                 205             


Pro Val Gly Ala Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    210                 215                 220                 


Lys Gly Gln Gln Gly Asn Arg Gly Leu Gly Phe Tyr Gly Val Lys Gly 
225                 230                 235                 240 


Glu Lys Gly Asp Val Gly Gln Pro Gly Pro Asn Gly Ile Pro Ser Asp 
                245                 250                 255     


Thr Leu His Pro Ile Ile Ala Pro Thr Gly Val Thr Phe His Pro Asp 
            260                 265                 270         


Gln Tyr Lys Gly Glu Lys Gly Ser Glu Gly Glu Pro Gly Ile Arg Gly 
        275                 280                 285             


Ile Ser Leu Lys Gly Glu Glu Gly Ile Met Gly Phe Pro Gly Leu Arg 
    290                 295                 300                 


Gly Tyr Pro Gly Leu Ser Gly Glu Lys Gly Ser Pro Gly Gln Lys Gly 
305                 310                 315                 320 


Ser Arg Gly Leu Asp Gly Tyr Gln Gly Pro Asp Gly Pro Arg Gly Pro 
                325                 330                 335     


Lys Gly Glu Ala Gly Asp Pro Gly Pro Pro Gly Leu Pro Ala Tyr Ser 
            340                 345                 350         


Pro His Pro Ser Leu Ala Lys Gly Ala Arg Gly Asp Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Gln Gly Glu Pro Gly Ser Gln Gly Glu Pro Gly Asp Pro Gly 
    370                 375                 380                 


Leu Pro Gly Pro Pro Gly Leu Ser Ile Gly Asp Gly Asp Gln Arg Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Glu Met Gly Pro Lys Gly Phe Ile Gly Asp Pro Gly 
                405                 410                 415     


Ile Pro Ala Leu Tyr Gly Gly Pro Pro Gly Pro Asp Gly Lys Arg Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Asp Gly Phe 
        435                 440                 445             


Leu Phe Gly Leu Lys Gly Ala Lys Gly Arg Ala Gly Phe Pro Gly Leu 
    450                 455                 460                 


Pro Gly Ser Pro Gly Ala Arg Gly Pro Lys Gly Trp Lys Gly Asp Ala 
465                 470                 475                 480 


Gly Glu Cys Arg Cys Thr Glu Gly Asp Glu Ala Ile Lys Gly Leu Pro 
                485                 490                 495     


Gly Leu Pro Gly Pro Lys Gly Phe Ala Gly Ile Asn Gly Glu Pro Gly 
            500                 505                 510         


Arg Lys Gly Asp Arg Gly Asp Pro Gly Gln His Gly Leu Pro Gly Phe 
        515                 520                 525             


Pro Gly Leu Lys Gly Val Pro Gly Asn Ile Gly Ala Pro Gly Pro Lys 
    530                 535                 540                 


Gly Ala Lys Gly Asp Ser Arg Thr Ile Thr Thr Lys Gly Glu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Val Pro Gly Val Pro Gly Met Lys Gly Asp Asp Gly Ser 
                565                 570                 575     


Pro Gly Arg Asp Gly Leu Asp Gly Phe Pro Gly Leu Pro Gly Pro Pro 
            580                 585                 590         


Gly Asp Gly Ile Lys Gly Pro Pro Gly Asp Pro Gly Tyr Pro Gly Ile 
        595                 600                 605             


Pro Gly Thr Lys Gly Thr Pro Gly Glu Met Gly Pro Pro Gly Leu Gly 
    610                 615                 620                 


Leu Pro Gly Leu Lys Gly Gln Arg Gly Phe Pro Gly Asp Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Phe Leu Gly Pro Pro Gly Pro Ala Gly Thr Pro 
                645                 650                 655     


Gly Gln Ile Asp Cys Asp Thr Asp Val Lys Arg Ala Val Gly Gly Asp 
            660                 665                 670         


Arg Gln Glu Ala Ile Gln Pro Gly Cys Ile Gly Gly Pro Lys Gly Leu 
        675                 680                 685             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Thr Gly Ala Lys Gly Leu Arg 
    690                 695                 700                 


Gly Ile Pro Gly Phe Ala Gly Ala Asp Gly Gly Pro Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Asp Ala Gly Arg Glu Gly Phe Pro Gly Pro Pro Gly Phe 
                725                 730                 735     


Ile Gly Pro Arg Gly Ser Lys Gly Ala Val Gly Leu Pro Gly Pro Asp 
            740                 745                 750         


Gly Ser Pro Gly Pro Ile Gly Leu Pro Gly Pro Asp Gly Pro Pro Gly 
        755                 760                 765             


Glu Arg Gly Leu Pro Gly Glu Val Leu Gly Ala Gln Pro Gly Pro Arg 
    770                 775                 780                 


Gly Asp Ala Gly Val Pro Gly Gln Pro Gly Leu Lys Gly Leu Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Pro Pro Gly Phe Arg Gly Ser Gln Gly Met Pro Gly Met 
                805                 810                 815     


Pro Gly Leu Lys Gly Gln Pro Gly Leu Pro Gly Pro Ser Gly Gln Pro 
            820                 825                 830         


Gly Leu Tyr Gly Pro Pro Gly Leu His Gly Phe Pro Gly Ala Pro Gly 
        835                 840                 845             


Gln Glu Gly Pro Leu Gly Leu Pro Gly Ile Pro Gly Arg Glu Gly Leu 
    850                 855                 860                 


Pro Gly Asp Arg Gly Asp Pro Gly Asp Thr Gly Ala Pro Gly Pro Val 
865                 870                 875                 880 


Gly Met Lys Gly Leu Ser Gly Asp Arg Gly Asp Ala Gly Phe Thr Gly 
                885                 890                 895     


Glu Gln Gly His Pro Gly Ser Pro Gly Phe Lys Gly Ile Asp Gly Met 
            900                 905                 910         


Pro Gly Thr Pro Gly Leu Lys Gly Asp Arg Gly Ser Pro Gly Met Asp 
        915                 920                 925             


Gly Phe Gln Gly Met Pro Gly Leu Lys Gly Arg Pro Gly Phe Pro Gly 
    930                 935                 940                 


Ser Lys Gly Glu Ala Gly Phe Phe Gly Ile Pro Gly Leu Lys Gly Leu 
945                 950                 955                 960 


Ala Gly Glu Pro Gly Phe Lys Gly Ser Arg Gly Asp Pro Gly Pro Pro 
                965                 970                 975     


Gly Pro Pro Pro Val Ile Leu Pro Gly Met Lys Asp Ile Lys Gly Glu 
            980                 985                 990         


Lys Gly Asp Glu Gly Pro Met Gly  Leu Lys Gly Tyr Leu  Gly Ala Lys 
        995                 1000                 1005             


Gly Ile  Gln Gly Met Pro Gly  Ile Pro Gly Leu Ser  Gly Ile Pro 
    1010                 1015                 1020             


Gly Leu  Pro Gly Arg Pro Gly  His Ile Lys Gly Val  Lys Gly Asp 
    1025                 1030                 1035             


Ile Gly  Val Pro Gly Ile Pro  Gly Leu Pro Gly Phe  Pro Gly Val 
    1040                 1045                 1050             


Ala Gly  Pro Pro Gly Ile Thr  Gly Phe Pro Gly Phe  Ile Gly Ser 
    1055                 1060                 1065             


Arg Gly  Asp Lys Gly Ala Pro  Gly Arg Ala Gly Leu  Tyr Gly Glu 
    1070                 1075                 1080             


Ile Gly  Ala Thr Gly Asp Phe  Gly Asp Ile Gly Asp  Thr Ile Asn 
    1085                 1090                 1095             


Leu Pro  Gly Arg Pro Gly Leu  Lys Gly Glu Arg Gly  Thr Thr Gly 
    1100                 1105                 1110             


Ile Pro  Gly Leu Lys Gly Phe  Phe Gly Glu Lys Gly  Thr Glu Gly 
    1115                 1120                 1125             


Asp Ile  Gly Phe Pro Gly Ile  Thr Gly Val Thr Gly  Val Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Leu Lys Gly Gln  Thr Gly Phe Pro Gly  Leu Thr Gly 
    1145                 1150                 1155             


Pro Pro  Gly Ser Gln Gly Glu  Leu Gly Arg Ile Gly  Leu Pro Gly 
    1160                 1165                 1170             


Gly Lys  Gly Asp Asp Gly Trp  Pro Gly Ala Pro Gly  Leu Pro Gly 
    1175                 1180                 1185             


Phe Pro  Gly Leu Arg Gly Ile  Arg Gly Leu His Gly  Leu Pro Gly 
    1190                 1195                 1200             


Thr Lys  Gly Phe Pro Gly Ser  Pro Gly Ser Asp Ile  His Gly Asp 
    1205                 1210                 1215             


Pro Gly  Phe Pro Gly Pro Pro  Gly Glu Arg Gly Asp  Pro Gly Glu 
    1220                 1225                 1230             


Ala Asn  Thr Leu Pro Gly Pro  Val Gly Val Pro Gly  Gln Lys Gly 
    1235                 1240                 1245             


Asp Gln  Gly Ala Pro Gly Glu  Arg Gly Pro Pro Gly  Ser Pro Gly 
    1250                 1255                 1260             


Leu Gln  Gly Phe Pro Gly Ile  Thr Pro Pro Ser Asn  Ile Ser Gly 
    1265                 1270                 1275             


Ala Pro  Gly Asp Lys Gly Ala  Pro Gly Ile Phe Gly  Leu Lys Gly 
    1280                 1285                 1290             


Tyr Arg  Gly Pro Pro Gly Pro  Pro Gly Ser Ala Ala  Leu Pro Gly 
    1295                 1300                 1305             


Ser Lys  Gly Asp Thr Gly Asn  Pro Gly Ala Pro Gly  Thr Pro Gly 
    1310                 1315                 1320             


Thr Lys  Gly Trp Ala Gly Asp  Ser Gly Pro Gln Gly  Arg Pro Gly 
    1325                 1330                 1335             


Val Phe  Gly Leu Pro Gly Glu  Lys Gly Pro Arg Gly  Glu Gln Gly 
    1340                 1345                 1350             


Phe Met  Gly Asn Thr Gly Pro  Thr Gly Ala Val Gly  Asp Arg Gly 
    1355                 1360                 1365             


Pro Lys  Gly Pro Lys Gly Asp  Pro Gly Phe Pro Gly  Ala Pro Gly 
    1370                 1375                 1380             


Thr Val  Gly Ala Pro Gly Ile  Ala Gly Ile Pro Gln  Lys Ile Ala 
    1385                 1390                 1395             


Val Gln  Pro Gly Thr Val Gly  Pro Gln Gly Arg Arg  Gly Pro Pro 
    1400                 1405                 1410             


Gly Ala  Pro Gly Glu Met Gly  Pro Gln Gly Pro Pro  Gly Glu Pro 
    1415                 1420                 1425             


Gly Phe  Arg Gly Ala Pro Gly  Lys Ala Gly Pro Gln  Gly Arg Gly 
    1430                 1435                 1440             


Gly Val  Ser Ala Val Pro Gly  Phe Arg Gly Asp Glu  Gly Pro Ile 
    1445                 1450                 1455             


Gly His  Gln Gly Pro Ile Gly  Gln Glu Gly Ala Pro  Gly Arg Pro 
    1460                 1465                 1470             


Gly Ser  Pro Gly Leu Pro Gly  Met Pro Gly Arg Ser  Val Ser Ile 
    1475                 1480                 1485             


Gly Tyr  Leu Leu Val Lys His  Ser Gln Thr Asp Gln  Glu Pro Met 
    1490                 1495                 1500             


Cys Pro  Val Gly Met Asn Lys  Leu Trp Ser Gly Tyr  Ser Leu Leu 
    1505                 1510                 1515             


Tyr Phe  Glu Gly Gln Glu Lys  Ala His Asn Gln Asp  Leu Gly Leu 
    1520                 1525                 1530             


Ala Gly  Ser Cys Leu Ala Arg  Phe Ser Thr Met Pro  Phe Leu Tyr 
    1535                 1540                 1545             


Cys Asn  Pro Gly Asp Val Cys  Tyr Tyr Ala Ser Arg  Asn Asp Lys 
    1550                 1555                 1560             


Ser Tyr  Trp Leu Ser Thr Thr  Ala Pro Leu Pro Met  Met Pro Val 
    1565                 1570                 1575             


Ala Glu  Asp Glu Ile Lys Pro  Tyr Ile Ser Arg Cys  Ser Val Cys 
    1580                 1585                 1590             


Glu Ala  Pro Ala Ile Ala Ile  Ala Val His Ser Gln  Asp Val Ser 
    1595                 1600                 1605             


Ile Pro  His Cys Pro Ala Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr 
    1610                 1615                 1620             


Ser Phe  Leu Met His Thr Ala  Ala Gly Asp Glu Gly  Gly Gly Gln 
    1625                 1630                 1635             


Ser Leu  Val Ser Pro Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr 
    1640                 1645                 1650             


Pro Phe  Ile Glu Cys Asn Gly  Gly Arg Gly Thr Cys  His Tyr Tyr 
    1655                 1660                 1665             


Ala Asn  Lys Tyr Ser Phe Trp  Leu Thr Thr Ile Pro  Glu Gln Ser 
    1670                 1675                 1680             


Phe Gln  Gly Ser Pro Ser Ala  Asp Thr Leu Lys Ala  Gly Leu Ile 
    1685                 1690                 1695             


Arg Thr  His Ile Ser Arg Cys  Gln Val Cys Met Lys  Asn Leu 
    1700                 1705                 1710         


<210>  2418
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL4A3BP__Homo_sapiens__NP_001123577

<400>  2418

Met Gln His Ser Cys Ile Pro Thr Pro Pro Ser Pro Phe Ser Ala Pro 
1               5                   10                  15      


Pro Ala Phe Leu Pro Val Val Thr Arg Glu Ser Arg Arg Gly Leu Ser 
            20                  25                  30          


Ser Gly Gly Ser Ala Gly Arg Asn Ala Gly Val Thr Ala Thr Ala Ala 
        35                  40                  45              


Ala Ala Asp Gly Trp Lys Gly Arg Leu Pro Ser Pro Leu Val Leu Leu 
    50                  55                  60                  


Pro Arg Ser Ala Arg Cys Gln Ala Arg Arg Arg Arg Gly Gly Arg Thr 
65                  70                  75                  80  


Ser Ser Leu Leu Leu Leu Pro Pro Thr Pro Glu Arg Ala Leu Phe Ala 
                85                  90                  95      


Ser Pro Ser Pro Asp Pro Ser Pro Arg Gly Leu Gly Ala Ser Ser Gly 
            100                 105                 110         


Ala Ala Glu Gly Ala Gly Ala Gly Leu Leu Leu Gly Cys Arg Ala Ser 
        115                 120                 125             


Met Ser Asp Asn Gln Ser Trp Asn Ser Ser Gly Ser Glu Glu Asp Pro 
    130                 135                 140                 


Glu Thr Glu Ser Gly Pro Pro Val Glu Arg Cys Gly Val Leu Ser Lys 
145                 150                 155                 160 


Trp Thr Asn Tyr Ile His Gly Trp Gln Asp Arg Trp Val Val Leu Lys 
                165                 170                 175     


Asn Asn Ala Leu Ser Tyr Tyr Lys Ser Glu Asp Glu Thr Glu Tyr Gly 
            180                 185                 190         


Cys Arg Gly Ser Ile Cys Leu Ser Lys Ala Val Ile Thr Pro His Asp 
        195                 200                 205             


Phe Asp Glu Cys Arg Phe Asp Ile Ser Val Asn Asp Ser Val Trp Tyr 
    210                 215                 220                 


Leu Arg Ala Gln Asp Pro Asp His Arg Gln Gln Trp Ile Asp Ala Ile 
225                 230                 235                 240 


Glu Gln His Lys Thr Glu Ser Gly Tyr Gly Ser Glu Ser Ser Leu Arg 
                245                 250                 255     


Arg His Gly Ser Met Val Ser Leu Val Ser Gly Ala Ser Gly Tyr Ser 
            260                 265                 270         


Ala Thr Ser Thr Ser Ser Phe Lys Lys Gly His Ser Leu Arg Glu Lys 
        275                 280                 285             


Leu Ala Glu Met Glu Thr Phe Arg Asp Ile Leu Cys Arg Gln Val Asp 
    290                 295                 300                 


Thr Leu Gln Lys Tyr Phe Asp Ala Cys Ala Asp Ala Val Ser Lys Asp 
305                 310                 315                 320 


Glu Leu Gln Arg Asp Lys Val Val Glu Asp Asp Glu Asp Asp Phe Pro 
                325                 330                 335     


Thr Thr Arg Ser Asp Gly Asp Phe Leu His Ser Thr Asn Gly Asn Lys 
            340                 345                 350         


Glu Lys Leu Phe Pro His Val Thr Pro Lys Gly Ile Asn Gly Ile Asp 
        355                 360                 365             


Phe Lys Gly Glu Ala Ile Thr Phe Lys Ala Thr Thr Ala Gly Ile Leu 
    370                 375                 380                 


Ala Thr Leu Ser His Cys Ile Glu Leu Met Val Lys Arg Glu Asp Ser 
385                 390                 395                 400 


Trp Gln Lys Arg Leu Asp Lys Glu Thr Glu Lys Lys Arg Arg Thr Glu 
                405                 410                 415     


Glu Ala Tyr Lys Asn Ala Met Thr Glu Leu Lys Lys Lys Ser His Phe 
            420                 425                 430         


Gly Gly Pro Asp Tyr Glu Glu Gly Pro Asn Ser Leu Ile Asn Glu Glu 
        435                 440                 445             


Glu Phe Phe Asp Ala Val Glu Ala Ala Leu Asp Arg Gln Asp Lys Ile 
    450                 455                 460                 


Glu Glu Gln Ser Gln Ser Glu Lys Val Arg Leu His Trp Pro Thr Ser 
465                 470                 475                 480 


Leu Pro Ser Gly Asp Ala Phe Ser Ser Val Gly Thr His Arg Phe Val 
                485                 490                 495     


Gln Lys Pro Tyr Ser Arg Ser Ser Ser Met Ser Ser Ile Asp Leu Val 
            500                 505                 510         


Ser Ala Ser Asp Asp Val His Arg Phe Ser Ser Gln Val Glu Glu Met 
        515                 520                 525             


Val Gln Asn His Met Thr Tyr Ser Leu Gln Asp Val Gly Gly Asp Ala 
    530                 535                 540                 


Asn Trp Gln Leu Val Val Glu Glu Gly Glu Met Lys Val Tyr Arg Arg 
545                 550                 555                 560 


Glu Val Glu Glu Asn Gly Ile Val Leu Asp Pro Leu Lys Ala Thr His 
                565                 570                 575     


Ala Val Lys Gly Val Thr Gly His Glu Val Cys Asn Tyr Phe Trp Asn 
            580                 585                 590         


Val Asp Val Arg Asn Asp Trp Glu Thr Thr Ile Glu Asn Phe His Val 
        595                 600                 605             


Val Glu Thr Leu Ala Asp Asn Ala Ile Ile Ile Tyr Gln Thr His Lys 
    610                 615                 620                 


Arg Val Trp Pro Ala Ser Gln Arg Asp Val Leu Tyr Leu Ser Val Ile 
625                 630                 635                 640 


Arg Lys Ile Pro Ala Leu Thr Glu Asn Asp Pro Glu Thr Trp Ile Val 
                645                 650                 655     


Cys Asn Phe Ser Val Asp His Asp Ser Ala Pro Leu Asn Asn Arg Cys 
            660                 665                 670         


Val Arg Ala Lys Ile Asn Val Ala Met Ile Cys Gln Thr Leu Val Ser 
        675                 680                 685             


Pro Pro Glu Gly Asn Gln Glu Ile Ser Arg Asp Asn Ile Leu Cys Lys 
    690                 695                 700                 


Ile Thr Tyr Val Ala Asn Val Asn Pro Gly Gly Trp Ala Pro Ala Ser 
705                 710                 715                 720 


Val Leu Arg Ala Val Ala Lys Arg Glu Tyr Pro Lys Phe Leu Lys Arg 
                725                 730                 735     


Phe Thr Ser Tyr Val Gln Glu Lys Thr Ala Gly Lys Pro Ile Leu Phe 
            740                 745                 750         


<210>  2419
<211>  1670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL4A3__Homo_sapiens__NP_000082

<400>  2419

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val 
            20                  25                  30          


Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys 
        35                  40                  45              


Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly 
    50                  55                  60                  


Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser 
                85                  90                  95      


Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly 
            100                 105                 110         


Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser 
        115                 120                 125             


Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala 
145                 150                 155                 160 


Lys Glu Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly 
            180                 185                 190         


Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala 
        195                 200                 205             


Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly 
    210                 215                 220                 


His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp 
                245                 250                 255     


Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro 
            260                 265                 270         


Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly 
        275                 280                 285             


Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val 
    290                 295                 300                 


Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro 
305                 310                 315                 320 


Gly Leu Met Gly Glu Asp Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly 
                325                 330                 335     


Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu 
            340                 345                 350         


Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg 
        355                 360                 365             


Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly 
    370                 375                 380                 


Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys 
385                 390                 395                 400 


Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr 
                405                 410                 415     


Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro 
        435                 440                 445             


Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly 
    450                 455                 460                 


Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro 
465                 470                 475                 480 


Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly 
                485                 490                 495     


Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro 
        515                 520                 525             


Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu 
    530                 535                 540                 


Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly 
545                 550                 555                 560 


Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Pro Gly Val 
                565                 570                 575     


Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys 
            580                 585                 590         


Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly 
        595                 600                 605             


Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro 
    610                 615                 620                 


Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly 
625                 630                 635                 640 


Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly 
                645                 650                 655     


Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro 
            660                 665                 670         


Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro 
        675                 680                 685             


Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu 
705                 710                 715                 720 


Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly 
                725                 730                 735     


Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro 
            740                 745                 750         


Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly 
        755                 760                 765             


Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn 
    770                 775                 780                 


Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala 
                805                 810                 815     


Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg 
            820                 825                 830         


Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg 
        835                 840                 845             


Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln 
    850                 855                 860                 


Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly 
865                 870                 875                 880 


Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe 
                885                 890                 895     


Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Thr Pro 
            900                 905                 910         


Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly 
        915                 920                 925             


Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro 
    930                 935                 940                 


Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys 
945                 950                 955                 960 


Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly 
                965                 970                 975     


Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro 
            980                 985                 990         


Pro Gly Pro Arg Gly Asp Leu Gly  Ser Thr Gly Asn Pro  Gly Glu Pro 
        995                 1000                 1005             


Gly Leu  Arg Gly Ile Pro Gly  Ser Met Gly Asn Met  Gly Met Pro 
    1010                 1015                 1020             


Gly Ser  Lys Gly Lys Arg Gly  Thr Leu Gly Phe Pro  Gly Arg Ala 
    1025                 1030                 1035             


Gly Arg  Pro Gly Leu Pro Gly  Ile His Gly Leu Gln  Gly Asp Lys 
    1040                 1045                 1050             


Gly Glu  Pro Gly Tyr Ser Glu  Gly Thr Arg Pro Gly  Pro Pro Gly 
    1055                 1060                 1065             


Pro Thr  Gly Asp Pro Gly Leu  Pro Gly Asp Met Gly  Lys Lys Gly 
    1070                 1075                 1080             


Glu Met  Gly Gln Pro Gly Pro  Pro Gly His Leu Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Glu  Gly Ala Pro Gly Ser  Pro Gly Ser Pro Gly  Leu Pro Gly 
    1100                 1105                 1110             


Lys Pro  Gly Pro His Gly Asp  Leu Gly Phe Lys Gly  Ile Lys Gly 
    1115                 1120                 1125             


Leu Leu  Gly Pro Pro Gly Ile  Arg Gly Pro Pro Gly  Leu Pro Gly 
    1130                 1135                 1140             


Phe Pro  Gly Ser Pro Gly Pro  Met Gly Ile Arg Gly  Asp Gln Gly 
    1145                 1150                 1155             


Arg Asp  Gly Ile Pro Gly Pro  Ala Gly Glu Lys Gly  Glu Thr Gly 
    1160                 1165                 1170             


Leu Leu  Arg Ala Pro Pro Gly  Pro Arg Gly Asn Pro  Gly Ala Gln 
    1175                 1180                 1185             


Gly Ala  Lys Gly Asp Arg Gly  Ala Pro Gly Phe Pro  Gly Leu Pro 
    1190                 1195                 1200             


Gly Arg  Lys Gly Ala Met Gly  Asp Ala Gly Pro Arg  Gly Pro Thr 
    1205                 1210                 1215             


Gly Ile  Glu Gly Phe Pro Gly  Pro Pro Gly Leu Pro  Gly Ala Ile 
    1220                 1225                 1230             


Ile Pro  Gly Gln Thr Gly Asn  Arg Gly Pro Pro Gly  Ser Arg Gly 
    1235                 1240                 1245             


Ser Pro  Gly Ala Pro Gly Pro  Pro Gly Pro Pro Gly  Ser His Val 
    1250                 1255                 1260             


Ile Gly  Ile Lys Gly Asp Lys  Gly Ser Met Gly His  Pro Gly Pro 
    1265                 1270                 1275             


Lys Gly  Pro Pro Gly Thr Ala  Gly Asp Met Gly Pro  Pro Gly Arg 
    1280                 1285                 1290             


Leu Gly  Ala Pro Gly Thr Pro  Gly Leu Pro Gly Pro  Arg Gly Asp 
    1295                 1300                 1305             


Pro Gly  Phe Gln Gly Phe Pro  Gly Val Lys Gly Glu  Lys Gly Asn 
    1310                 1315                 1320             


Pro Gly  Phe Leu Gly Ser Ile  Gly Pro Pro Gly Pro  Ile Gly Pro 
    1325                 1330                 1335             


Lys Gly  Pro Pro Gly Val Arg  Gly Asp Pro Gly Thr  Leu Lys Ile 
    1340                 1345                 1350             


Ile Ser  Leu Pro Gly Ser Pro  Gly Pro Pro Gly Thr  Pro Gly Glu 
    1355                 1360                 1365             


Pro Gly  Met Gln Gly Glu Pro  Gly Pro Pro Gly Pro  Pro Gly Asn 
    1370                 1375                 1380             


Leu Gly  Pro Cys Gly Pro Arg  Gly Lys Pro Gly Lys  Asp Gly Lys 
    1385                 1390                 1395             


Pro Gly  Thr Pro Gly Pro Ala  Gly Glu Lys Gly Asn  Lys Gly Ser 
    1400                 1405                 1410             


Lys Gly  Glu Pro Gly Pro Ala  Gly Ser Asp Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Lys Gly  Lys Arg Gly Asp Ser  Gly Ser Pro Ala Thr  Trp Thr Thr 
    1430                 1435                 1440             


Arg Gly  Phe Val Phe Thr Arg  His Ser Gln Thr Thr  Ala Ile Pro 
    1445                 1450                 1455             


Ser Cys  Pro Glu Gly Thr Val  Pro Leu Tyr Ser Gly  Phe Ser Phe 
    1460                 1465                 1470             


Leu Phe  Val Gln Gly Asn Gln  Arg Ala His Gly Gln  Asp Leu Gly 
    1475                 1480                 1485             


Thr Leu  Gly Ser Cys Leu Gln  Arg Phe Thr Thr Met  Pro Phe Leu 
    1490                 1495                 1500             


Phe Cys  Asn Val Asn Asp Val  Cys Asn Phe Ala Ser  Arg Asn Asp 
    1505                 1510                 1515             


Tyr Ser  Tyr Trp Leu Ser Thr  Pro Ala Leu Met Pro  Met Asn Met 
    1520                 1525                 1530             


Ala Pro  Ile Thr Gly Arg Ala  Leu Glu Pro Tyr Ile  Ser Arg Cys 
    1535                 1540                 1545             


Thr Val  Cys Glu Gly Pro Ala  Ile Ala Ile Ala Val  His Ser Gln 
    1550                 1555                 1560             


Thr Thr  Asp Ile Pro Pro Cys  Pro His Gly Trp Ile  Ser Leu Trp 
    1565                 1570                 1575             


Lys Gly  Phe Ser Phe Ile Met  Phe Thr Ser Ala Gly  Ser Glu Gly 
    1580                 1585                 1590             


Thr Gly  Gln Ala Leu Ala Ser  Pro Gly Ser Cys Leu  Glu Glu Phe 
    1595                 1600                 1605             


Arg Ala  Ser Pro Phe Leu Glu  Cys His Gly Arg Gly  Thr Cys Asn 
    1610                 1615                 1620             


Tyr Tyr  Ser Asn Ser Tyr Ser  Phe Trp Leu Ala Ser  Leu Asn Pro 
    1625                 1630                 1635             


Glu Arg  Met Phe Arg Lys Pro  Ile Pro Ser Thr Val  Lys Ala Gly 
    1640                 1645                 1650             


Glu Leu  Glu Lys Ile Ile Ser  Arg Cys Gln Val Cys  Met Lys Lys 
    1655                 1660                 1665             


Arg His  
    1670 


<210>  2420
<211>  1690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL4A4__Homo_sapiens__XP_005246338

<400>  2420

Met Trp Ser Leu His Ile Val Leu Met Arg Cys Ser Phe Arg Leu Thr 
1               5                   10                  15      


Lys Ser Leu Ala Thr Gly Pro Trp Ser Leu Ile Leu Ile Leu Phe Ser 
            20                  25                  30          


Val Gln Tyr Val Tyr Gly Ser Gly Lys Lys Tyr Ile Gly Pro Cys Gly 
        35                  40                  45              


Gly Arg Asp Cys Ser Val Cys His Cys Val Pro Glu Lys Gly Ser Arg 
    50                  55                  60                  


Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Ile Gly Pro Leu Gly 
65                  70                  75                  80  


Ala Pro Gly Pro Ile Gly Leu Ser Gly Glu Lys Gly Met Arg Gly Asp 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ala Gly Asp Lys Gly Asp Lys Gly Pro Thr 
            100                 105                 110         


Gly Val Pro Gly Phe Pro Gly Leu Asp Gly Ile Pro Gly His Pro Gly 
        115                 120                 125             


Pro Pro Gly Pro Arg Gly Lys Pro Gly Met Ser Gly His Asn Gly Ser 
    130                 135                 140                 


Arg Gly Asp Pro Gly Phe Pro Gly Gly Arg Gly Ala Leu Gly Pro Gly 
145                 150                 155                 160 


Gly Pro Leu Gly His Pro Gly Glu Lys Gly Glu Lys Gly Asn Ser Val 
                165                 170                 175     


Phe Ile Leu Gly Ala Val Lys Gly Ile Gln Gly Asp Arg Gly Asp Pro 
            180                 185                 190         


Gly Leu Pro Gly Leu Pro Gly Ser Trp Gly Ala Gly Gly Pro Ala Gly 
        195                 200                 205             


Pro Thr Gly Tyr Pro Gly Glu Pro Gly Leu Val Gly Pro Pro Gly Gln 
    210                 215                 220                 


Pro Gly Arg Pro Gly Leu Lys Gly Asn Pro Gly Val Gly Val Lys Gly 
225                 230                 235                 240 


Gln Met Gly Asp Pro Gly Glu Val Gly Gln Gln Gly Ser Pro Gly Pro 
                245                 250                 255     


Thr Leu Leu Val Glu Pro Pro Asp Phe Cys Leu Tyr Lys Gly Glu Lys 
            260                 265                 270         


Gly Ile Lys Gly Ile Pro Gly Met Val Gly Leu Pro Gly Pro Pro Gly 
        275                 280                 285             


Arg Lys Gly Glu Ser Gly Ile Gly Ala Lys Gly Glu Lys Gly Ile Pro 
    290                 295                 300                 


Gly Phe Pro Gly Pro Arg Gly Asp Pro Gly Ser Tyr Gly Ser Pro Gly 
305                 310                 315                 320 


Phe Pro Gly Leu Lys Gly Glu Leu Gly Leu Val Gly Asp Pro Gly Leu 
                325                 330                 335     


Phe Gly Leu Ile Gly Pro Lys Gly Asp Pro Gly Asn Arg Gly His Pro 
            340                 345                 350         


Gly Pro Pro Gly Val Leu Val Thr Pro Pro Leu Pro Leu Lys Gly Pro 
        355                 360                 365             


Pro Gly Asp Pro Gly Phe Pro Gly Arg Tyr Gly Glu Thr Gly Asp Val 
    370                 375                 380                 


Gly Pro Pro Gly Pro Pro Gly Leu Leu Gly Arg Pro Gly Glu Ala Cys 
385                 390                 395                 400 


Ala Gly Met Ile Gly Pro Pro Gly Pro Gln Gly Phe Pro Gly Leu Pro 
                405                 410                 415     


Gly Leu Pro Gly Glu Ala Gly Ile Pro Gly Arg Pro Asp Ser Ala Pro 
            420                 425                 430         


Gly Lys Pro Gly Lys Pro Gly Ser Pro Gly Leu Pro Gly Ala Pro Gly 
        435                 440                 445             


Leu Gln Gly Leu Pro Gly Ser Ser Val Ile Tyr Cys Ser Val Gly Asn 
    450                 455                 460                 


Pro Gly Pro Gln Gly Ile Lys Gly Lys Val Gly Pro Pro Gly Gly Arg 
465                 470                 475                 480 


Gly Pro Lys Gly Glu Lys Gly Asn Glu Gly Leu Cys Ala Cys Glu Pro 
                485                 490                 495     


Gly Pro Met Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Arg Gln Gly 
            500                 505                 510         


Ser Lys Gly Asp Leu Gly Leu Pro Gly Trp Leu Gly Thr Lys Gly Asp 
        515                 520                 525             


Pro Gly Pro Pro Gly Ala Glu Gly Pro Pro Gly Leu Pro Gly Lys His 
    530                 535                 540                 


Gly Ala Ser Gly Pro Pro Gly Asn Lys Gly Ala Lys Gly Asp Met Val 
545                 550                 555                 560 


Val Ser Arg Val Lys Gly His Lys Gly Glu Arg Gly Pro Asp Gly Pro 
                565                 570                 575     


Pro Gly Phe Pro Gly Gln Pro Gly Ser His Gly Arg Asp Gly His Ala 
            580                 585                 590         


Gly Glu Lys Gly Asp Pro Gly Pro Pro Gly Asp His Glu Asp Ala Thr 
        595                 600                 605             


Pro Gly Gly Lys Gly Phe Pro Gly Pro Leu Gly Pro Pro Gly Lys Ala 
    610                 615                 620                 


Gly Pro Val Gly Pro Pro Gly Leu Gly Phe Pro Gly Pro Pro Gly Glu 
625                 630                 635                 640 


Arg Gly His Pro Gly Val Pro Gly His Pro Gly Val Arg Gly Pro Asp 
                645                 650                 655     


Gly Leu Lys Gly Gln Lys Gly Asp Thr Ile Ser Cys Asn Val Thr Tyr 
            660                 665                 670         


Pro Gly Arg His Gly Pro Pro Gly Phe Asp Gly Pro Pro Gly Pro Lys 
        675                 680                 685             


Gly Phe Pro Gly Pro Gln Gly Ala Pro Gly Leu Ser Gly Ser Asp Gly 
    690                 695                 700                 


His Lys Gly Arg Pro Gly Thr Pro Gly Thr Ala Glu Ile Pro Gly Pro 
705                 710                 715                 720 


Pro Gly Phe Arg Gly Asp Met Gly Asp Pro Gly Phe Gly Gly Glu Lys 
                725                 730                 735     


Gly Ser Ser Pro Val Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Val 
            740                 745                 750         


Asn Gly Gln Lys Gly Ile Pro Gly Asp Pro Ala Phe Gly His Leu Gly 
        755                 760                 765             


Pro Pro Gly Lys Arg Gly Leu Ser Gly Val Pro Gly Ile Lys Gly Pro 
    770                 775                 780                 


Arg Gly Asp Pro Gly Cys Pro Gly Ala Glu Gly Pro Ala Gly Ile Pro 
785                 790                 795                 800 


Gly Phe Leu Gly Leu Lys Gly Pro Lys Gly Arg Glu Gly His Ala Gly 
                805                 810                 815     


Phe Pro Gly Val Pro Gly Pro Pro Gly His Ser Cys Glu Arg Gly Ala 
            820                 825                 830         


Pro Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Tyr Pro Gly Ser Pro 
        835                 840                 845             


Gly Ala Pro Gly Gly Lys Gly Gln Pro Gly Asp Val Gly Pro Pro Gly 
    850                 855                 860                 


Pro Ala Gly Met Lys Gly Leu Pro Gly Leu Pro Gly Arg Pro Gly Ala 
865                 870                 875                 880 


His Gly Pro Pro Gly Leu Pro Gly Ile Pro Gly Pro Phe Gly Asp Asp 
                885                 890                 895     


Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Pro Arg Gly Leu Pro Gly 
            900                 905                 910         


Phe Pro Gly Phe Pro Gly Glu Arg Gly Lys Pro Gly Ala Glu Gly Cys 
        915                 920                 925             


Pro Gly Ala Lys Gly Glu Pro Gly Glu Lys Gly Met Ser Gly Leu Pro 
    930                 935                 940                 


Gly Asp Arg Gly Leu Arg Gly Ala Lys Gly Ala Ile Gly Pro Pro Gly 
945                 950                 955                 960 


Asp Glu Gly Glu Met Ala Ile Ile Ser Gln Lys Gly Thr Pro Gly Glu 
                965                 970                 975     


Pro Gly Pro Pro Gly Asp Asp Gly Phe Pro Gly Glu Arg Gly Asp Lys 
            980                 985                 990         


Gly Thr Pro Gly Met Gln Gly Arg  Arg Gly Glu Pro Gly  Arg Tyr Gly 
        995                 1000                 1005             


Pro Pro  Gly Phe His Arg Gly  Glu Pro Gly Glu Lys  Gly Gln Pro 
    1010                 1015                 1020             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly Ser Thr  Gly Leu Arg 
    1025                 1030                 1035             


Gly Phe  Ile Gly Phe Pro Gly  Leu Pro Gly Asp Gln  Gly Glu Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Pro Pro Gly  Phe Ser Gly Ile Asp  Gly Ala Arg 
    1055                 1060                 1065             


Gly Pro  Lys Gly Asn Lys Gly  Asp Pro Ala Ser His  Phe Gly Pro 
    1070                 1075                 1080             


Pro Gly  Pro Lys Gly Glu Pro  Gly Ser Pro Gly Cys  Pro Gly His 
    1085                 1090                 1095             


Phe Gly  Ala Ser Gly Glu Gln  Gly Leu Pro Gly Ile  Gln Gly Pro 
    1100                 1105                 1110             


Arg Gly  Ser Pro Gly Arg Pro  Gly Pro Pro Gly Ser  Ser Gly Pro 
    1115                 1120                 1125             


Pro Gly  Cys Pro Gly Asp His  Gly Met Pro Gly Leu  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Glu Met Gly Asp Pro  Gly Pro Arg Gly Leu  Gln Gly Asp 
    1145                 1150                 1155             


Pro Gly  Ile Pro Gly Pro Pro  Gly Ile Lys Gly Pro  Ser Gly Ser 
    1160                 1165                 1170             


Pro Gly  Leu Asn Gly Leu His  Gly Leu Lys Gly Gln  Lys Gly Thr 
    1175                 1180                 1185             


Lys Gly  Ala Ser Gly Leu His  Asp Val Gly Pro Pro  Gly Pro Val 
    1190                 1195                 1200             


Gly Ile  Pro Gly Leu Lys Gly  Glu Arg Gly Asp Pro  Gly Ser Pro 
    1205                 1210                 1215             


Gly Ile  Ser Pro Pro Gly Pro  Arg Gly Lys Lys Gly  Pro Pro Gly 
    1220                 1225                 1230             


Pro Pro  Gly Ser Ser Gly Pro  Pro Gly Pro Ala Gly  Ala Thr Gly 
    1235                 1240                 1245             


Arg Ala  Pro Lys Asp Ile Pro  Asp Pro Gly Pro Pro  Gly Asp Gln 
    1250                 1255                 1260             


Gly Pro  Pro Gly Pro Asp Gly  Pro Arg Gly Ala Pro  Gly Pro Pro 
    1265                 1270                 1275             


Gly Leu  Pro Gly Ser Val Asp  Leu Leu Arg Gly Glu  Pro Gly Asp 
    1280                 1285                 1290             


Cys Gly  Leu Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Tyr Lys Gly Phe Pro  Gly Cys Asp Gly Lys  Asp Gly Gln 
    1310                 1315                 1320             


Lys Gly  Pro Val Gly Phe Pro  Gly Pro Gln Gly Pro  His Gly Phe 
    1325                 1330                 1335             


Pro Gly  Pro Pro Gly Glu Lys  Gly Leu Pro Gly Pro  Pro Gly Arg 
    1340                 1345                 1350             


Lys Gly  Pro Thr Gly Leu Pro  Gly Pro Arg Gly Glu  Pro Gly Pro 
    1355                 1360                 1365             


Pro Ala  Asp Val Asp Asp Cys  Pro Arg Ile Pro Gly  Leu Pro Gly 
    1370                 1375                 1380             


Ala Pro  Gly Met Arg Gly Pro  Glu Gly Ala Met Gly  Leu Pro Gly 
    1385                 1390                 1395             


Met Arg  Gly Pro Ser Gly Pro  Gly Cys Lys Gly Glu  Pro Gly Leu 
    1400                 1405                 1410             


Asp Gly  Arg Arg Gly Val Asp  Gly Val Pro Gly Ser  Pro Gly Pro 
    1415                 1420                 1425             


Pro Gly  Arg Lys Gly Asp Thr  Gly Glu Asp Gly Tyr  Pro Gly Gly 
    1430                 1435                 1440             


Pro Gly  Pro Pro Gly Pro Ile  Gly Asp Pro Gly Pro  Lys Gly Phe 
    1445                 1450                 1455             


Gly Pro  Gly Tyr Leu Gly Gly  Phe Leu Leu Val Leu  His Ser Gln 
    1460                 1465                 1470             


Thr Asp  Gln Glu Pro Thr Cys  Pro Leu Gly Met Pro  Arg Leu Trp 
    1475                 1480                 1485             


Thr Gly  Tyr Ser Leu Leu Tyr  Leu Glu Gly Gln Glu  Lys Ala His 
    1490                 1495                 1500             


Asn Gln  Asp Leu Gly Leu Ala  Gly Ser Cys Leu Pro  Val Phe Ser 
    1505                 1510                 1515             


Thr Leu  Pro Phe Ala Tyr Cys  Asn Ile His Gln Val  Cys His Tyr 
    1520                 1525                 1530             


Ala Gln  Arg Asn Asp Arg Ser  Tyr Trp Leu Ala Ser  Ala Ala Pro 
    1535                 1540                 1545             


Leu Pro  Met Met Pro Leu Ser  Glu Glu Ala Ile Arg  Pro Tyr Val 
    1550                 1555                 1560             


Ser Arg  Cys Ala Val Cys Glu  Ala Pro Ala Gln Ala  Val Ala Val 
    1565                 1570                 1575             


His Ser  Gln Asp Gln Ser Ile  Pro Pro Cys Pro Gln  Thr Trp Arg 
    1580                 1585                 1590             


Ser Leu  Trp Ile Gly Tyr Ser  Phe Leu Met His Thr  Gly Ala Gly 
    1595                 1600                 1605             


Asp Gln  Gly Gly Gly Gln Ala  Leu Met Ser Pro Gly  Ser Cys Leu 
    1610                 1615                 1620             


Glu Asp  Phe Arg Ala Ala Pro  Phe Leu Glu Cys Gln  Gly Arg Gln 
    1625                 1630                 1635             


Gly Thr  Cys His Phe Phe Ala  Asn Lys Tyr Ser Phe  Trp Leu Thr 
    1640                 1645                 1650             


Thr Val  Lys Ala Asp Leu Gln  Phe Ser Ser Ala Pro  Ala Pro Asp 
    1655                 1660                 1665             


Thr Leu  Lys Glu Ser Gln Ala  Gln Arg Gln Lys Ile  Ser Arg Cys 
    1670                 1675                 1680             


Gln Val  Cys Val Lys Tyr Ser  
    1685                 1690 


<210>  2421
<211>  1685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL4A5__Homo_sapiens__NP_000486

<400>  2421

Met Lys Leu Arg Gly Val Ser Leu Ala Ala Gly Leu Phe Leu Leu Ala 
1               5                   10                  15      


Leu Ser Leu Trp Gly Gln Pro Ala Glu Ala Ala Ala Cys Tyr Gly Cys 
            20                  25                  30          


Ser Pro Gly Ser Lys Cys Asp Cys Ser Gly Ile Lys Gly Glu Lys Gly 
        35                  40                  45              


Glu Arg Gly Phe Pro Gly Leu Glu Gly His Pro Gly Leu Pro Gly Phe 
    50                  55                  60                  


Pro Gly Pro Glu Gly Pro Pro Gly Pro Arg Gly Gln Lys Gly Asp Asp 
65                  70                  75                  80  


Gly Ile Pro Gly Pro Pro Gly Pro Lys Gly Ile Arg Gly Pro Pro Gly 
                85                  90                  95      


Leu Pro Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Met Pro Gly His 
            100                 105                 110         


Asp Gly Ala Pro Gly Pro Gln Gly Ile Pro Gly Cys Asn Gly Thr Lys 
        115                 120                 125             


Gly Glu Arg Gly Phe Pro Gly Ser Pro Gly Phe Pro Gly Leu Gln Gly 
    130                 135                 140                 


Pro Pro Gly Pro Pro Gly Ile Pro Gly Met Lys Gly Glu Pro Gly Ser 
145                 150                 155                 160 


Ile Ile Met Ser Ser Leu Pro Gly Pro Lys Gly Asn Pro Gly Tyr Pro 
                165                 170                 175     


Gly Pro Pro Gly Ile Gln Gly Leu Pro Gly Pro Thr Gly Ile Pro Gly 
            180                 185                 190         


Pro Ile Gly Pro Pro Gly Pro Pro Gly Leu Met Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Leu Pro Gly Pro Lys Gly Asn Met Gly Leu Asn Phe Gln Gly 
    210                 215                 220                 


Pro Lys Gly Glu Lys Gly Glu Gln Gly Leu Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln 
                245                 250                 255     


Lys Gly Asp Gln Gly Leu Pro Gly Asp Arg Gly Pro Pro Gly Pro Pro 
            260                 265                 270         


Gly Ile Arg Gly Pro Pro Gly Pro Pro Gly Gly Glu Lys Gly Glu Lys 
        275                 280                 285             


Gly Glu Gln Gly Glu Pro Gly Lys Arg Gly Lys Pro Gly Lys Asp Gly 
    290                 295                 300                 


Glu Asn Gly Gln Pro Gly Ile Pro Gly Leu Pro Gly Asp Pro Gly Tyr 
305                 310                 315                 320 


Pro Gly Glu Pro Gly Arg Asp Gly Glu Lys Gly Gln Lys Gly Asp Thr 
                325                 330                 335     


Gly Pro Pro Gly Pro Pro Gly Leu Val Ile Pro Arg Pro Gly Thr Gly 
            340                 345                 350         


Ile Thr Ile Gly Glu Lys Gly Asn Ile Gly Leu Pro Gly Leu Pro Gly 
        355                 360                 365             


Glu Lys Gly Glu Arg Gly Phe Pro Gly Ile Gln Gly Pro Pro Gly Leu 
    370                 375                 380                 


Pro Gly Pro Pro Gly Ala Ala Val Met Gly Pro Pro Gly Pro Pro Gly 
385                 390                 395                 400 


Phe Pro Gly Glu Arg Gly Gln Lys Gly Asp Glu Gly Pro Pro Gly Ile 
                405                 410                 415     


Ser Ile Pro Gly Pro Pro Gly Leu Asp Gly Gln Pro Gly Ala Pro Gly 
            420                 425                 430         


Leu Pro Gly Pro Pro Gly Pro Ala Gly Pro His Ile Pro Pro Ser Asp 
        435                 440                 445             


Glu Ile Cys Glu Pro Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Asp 
    450                 455                 460                 


Lys Gly Leu Gln Gly Glu Gln Gly Val Lys Gly Asp Lys Gly Asp Thr 
465                 470                 475                 480 


Cys Phe Asn Cys Ile Gly Thr Gly Ile Ser Gly Pro Pro Gly Gln Pro 
                485                 490                 495     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Ser Leu Gly Phe Pro Gly 
            500                 505                 510         


Gln Lys Gly Glu Lys Gly Gln Ala Gly Ala Thr Gly Pro Lys Gly Leu 
        515                 520                 525             


Pro Gly Ile Pro Gly Ala Pro Gly Ala Pro Gly Phe Pro Gly Ser Lys 
    530                 535                 540                 


Gly Glu Pro Gly Asp Ile Leu Thr Phe Pro Gly Met Lys Gly Asp Lys 
545                 550                 555                 560 


Gly Glu Leu Gly Ser Pro Gly Ala Pro Gly Leu Pro Gly Leu Pro Gly 
                565                 570                 575     


Thr Pro Gly Gln Asp Gly Leu Pro Gly Leu Pro Gly Pro Lys Gly Glu 
            580                 585                 590         


Pro Gly Gly Ile Thr Phe Lys Gly Glu Arg Gly Pro Pro Gly Asn Pro 
        595                 600                 605             


Gly Leu Pro Gly Leu Pro Gly Asn Ile Gly Pro Met Gly Pro Pro Gly 
    610                 615                 620                 


Phe Gly Pro Pro Gly Pro Val Gly Glu Lys Gly Ile Gln Gly Val Ala 
625                 630                 635                 640 


Gly Asn Pro Gly Gln Pro Gly Ile Pro Gly Pro Lys Gly Asp Pro Gly 
                645                 650                 655     


Gln Thr Ile Thr Gln Pro Gly Lys Pro Gly Leu Pro Gly Asn Pro Gly 
            660                 665                 670         


Arg Asp Gly Asp Val Gly Leu Pro Gly Asp Pro Gly Leu Pro Gly Gln 
        675                 680                 685             


Pro Gly Leu Pro Gly Ile Pro Gly Ser Lys Gly Glu Pro Gly Ile Pro 
    690                 695                 700                 


Gly Ile Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Phe Pro Gly Ile 
705                 710                 715                 720 


Pro Gly Pro Pro Gly Ala Pro Gly Thr Pro Gly Arg Ile Gly Leu Glu 
                725                 730                 735     


Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly Pro Lys Gly Glu Pro Gly 
            740                 745                 750         


Phe Ala Leu Pro Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly Phe Lys 
        755                 760                 765             


Gly Ala Leu Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Pro Gly Arg Thr Gly Leu Asp Gly Leu Pro Gly Pro Lys Gly Asp 
785                 790                 795                 800 


Val Gly Pro Asn Gly Gln Pro Gly Pro Met Gly Pro Pro Gly Leu Pro 
                805                 810                 815     


Gly Ile Gly Val Gln Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Pro 
            820                 825                 830         


Ile Gly Gln Pro Gly Leu His Gly Ile Pro Gly Glu Lys Gly Asp Pro 
        835                 840                 845             


Gly Pro Pro Gly Leu Asp Val Pro Gly Pro Pro Gly Glu Arg Gly Ser 
    850                 855                 860                 


Pro Gly Ile Pro Gly Ala Pro Gly Pro Ile Gly Pro Pro Gly Ser Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Lys Ala Gly Ala Ser Gly Phe Pro Gly Thr Lys Gly 
                885                 890                 895     


Glu Met Gly Met Met Gly Pro Pro Gly Pro Pro Gly Pro Leu Gly Ile 
            900                 905                 910         


Pro Gly Arg Ser Gly Val Pro Gly Leu Lys Gly Asp Asp Gly Leu Gln 
        915                 920                 925             


Gly Gln Pro Gly Leu Pro Gly Pro Thr Gly Glu Lys Gly Ser Lys Gly 
    930                 935                 940                 


Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro Met Asp Pro Asn Leu Leu 
945                 950                 955                 960 


Gly Ser Lys Gly Glu Lys Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
                965                 970                 975     


Val Ser Gly Pro Lys Gly Tyr Gln Gly Leu Pro Gly Asp Pro Gly Gln 
            980                 985                 990         


Pro Gly Leu Ser Gly Gln Pro Gly  Leu Pro Gly Pro Pro  Gly Pro Lys 
        995                 1000                 1005             


Gly Asn  Pro Gly Leu Pro Gly  Gln Pro Gly Leu Ile  Gly Pro Pro 
    1010                 1015                 1020             


Gly Leu  Lys Gly Thr Ile Gly  Asp Met Gly Phe Pro  Gly Pro Gln 
    1025                 1030                 1035             


Gly Val  Glu Gly Pro Pro Gly  Pro Ser Gly Val Pro  Gly Gln Pro 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Gln Lys Gly Asp Lys  Gly Asp Pro 
    1055                 1060                 1065             


Gly Ile  Ser Ser Ile Gly Leu  Pro Gly Leu Pro Gly  Pro Lys Gly 
    1070                 1075                 1080             


Glu Pro  Gly Leu Pro Gly Tyr  Pro Gly Asn Pro Gly  Ile Lys Gly 
    1085                 1090                 1095             


Ser Val  Gly Asp Pro Gly Leu  Pro Gly Leu Pro Gly  Thr Pro Gly 
    1100                 1105                 1110             


Ala Lys  Gly Gln Pro Gly Leu  Pro Gly Phe Pro Gly  Thr Pro Gly 
    1115                 1120                 1125             


Pro Pro  Gly Pro Lys Gly Ile  Ser Gly Pro Pro Gly  Asn Pro Gly 
    1130                 1135                 1140             


Leu Pro  Gly Glu Pro Gly Pro  Val Gly Gly Gly Gly  His Pro Gly 
    1145                 1150                 1155             


Gln Pro  Gly Pro Pro Gly Glu  Lys Gly Lys Pro Gly  Gln Asp Gly 
    1160                 1165                 1170             


Ile Pro  Gly Pro Ala Gly Gln  Lys Gly Glu Pro Gly  Gln Pro Gly 
    1175                 1180                 1185             


Phe Gly  Asn Pro Gly Pro Pro  Gly Leu Pro Gly Leu  Ser Gly Gln 
    1190                 1195                 1200             


Lys Gly  Asp Gly Gly Leu Pro  Gly Ile Pro Gly Asn  Pro Gly Leu 
    1205                 1210                 1215             


Pro Gly  Pro Lys Gly Glu Pro  Gly Phe His Gly Phe  Pro Gly Val 
    1220                 1225                 1230             


Gln Gly  Pro Pro Gly Pro Pro  Gly Ser Pro Gly Pro  Ala Leu Glu 
    1235                 1240                 1245             


Gly Pro  Lys Gly Asn Pro Gly  Pro Gln Gly Pro Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Pro Gly Pro Glu Gly  Pro Pro Gly Leu Pro  Gly Asn Gly 
    1265                 1270                 1275             


Gly Ile  Lys Gly Glu Lys Gly  Asn Pro Gly Gln Pro  Gly Leu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Leu Lys Gly  Asp Gln Gly Pro Pro  Gly Leu Gln 
    1295                 1300                 1305             


Gly Asn  Pro Gly Arg Pro Gly  Leu Asn Gly Met Lys  Gly Asp Pro 
    1310                 1315                 1320             


Gly Leu  Pro Gly Val Pro Gly  Phe Pro Gly Met Lys  Gly Pro Ser 
    1325                 1330                 1335             


Gly Val  Pro Gly Ser Ala Gly  Pro Glu Gly Glu Pro  Gly Leu Ile 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly Pro Ser  Gly Gln Ser 
    1355                 1360                 1365             


Ile Ile  Ile Lys Gly Asp Ala  Gly Pro Pro Gly Ile  Pro Gly Gln 
    1370                 1375                 1380             


Pro Gly  Leu Lys Gly Leu Pro  Gly Pro Gln Gly Pro  Gln Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Thr Gly Pro Pro  Gly Asp Pro Gly Arg  Asn Gly Leu 
    1400                 1405                 1410             


Pro Gly  Phe Asp Gly Ala Gly  Gly Arg Lys Gly Asp  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Gln Pro Gly Thr Arg  Gly Leu Asp Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Asp Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Thr  Ser Ser Val 
    1445                 1450                 1455             


Ala His  Gly Phe Leu Ile Thr  Arg His Ser Gln Thr  Thr Asp Ala 
    1460                 1465                 1470             


Pro Gln  Cys Pro Gln Gly Thr  Leu Gln Val Tyr Glu  Gly Phe Ser 
    1475                 1480                 1485             


Leu Leu  Tyr Val Gln Gly Asn  Lys Arg Ala His Gly  Gln Asp Leu 
    1490                 1495                 1500             


Gly Thr  Ala Gly Ser Cys Leu  Arg Arg Phe Ser Thr  Met Pro Phe 
    1505                 1510                 1515             


Met Phe  Cys Asn Ile Asn Asn  Val Cys Asn Phe Ala  Ser Arg Asn 
    1520                 1525                 1530             


Asp Tyr  Ser Tyr Trp Leu Ser  Thr Pro Glu Pro Met  Pro Met Ser 
    1535                 1540                 1545             


Met Gln  Pro Leu Lys Gly Gln  Ser Ile Gln Pro Phe  Ile Ser Arg 
    1550                 1555                 1560             


Cys Ala  Val Cys Glu Ala Pro  Ala Val Val Ile Ala  Val His Ser 
    1565                 1570                 1575             


Gln Thr  Ile Gln Ile Pro His  Cys Pro Gln Gly Trp  Asp Ser Leu 
    1580                 1585                 1590             


Trp Ile  Gly Tyr Ser Phe Met  Met His Thr Ser Ala  Gly Ala Glu 
    1595                 1600                 1605             


Gly Ser  Gly Gln Ala Leu Ala  Ser Pro Gly Ser Cys  Leu Glu Glu 
    1610                 1615                 1620             


Phe Arg  Ser Ala Pro Phe Ile  Glu Cys His Gly Arg  Gly Thr Cys 
    1625                 1630                 1635             


Asn Tyr  Tyr Ala Asn Ser Tyr  Ser Phe Trp Leu Ala  Thr Val Asp 
    1640                 1645                 1650             


Val Ser  Asp Met Phe Ser Lys  Pro Gln Ser Glu Thr  Leu Lys Ala 
    1655                 1660                 1665             


Gly Asp  Leu Arg Thr Arg Ile  Ser Arg Cys Gln Val  Cys Met Lys 
    1670                 1675                 1680             


Arg Thr  
    1685 


<210>  2422
<211>  1666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL4A6__Homo_sapiens__NP_001274688

<400>  2422

Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser Thr 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Thr Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Thr Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Thr Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Pro Ser Ile Thr Gly  Val Pro Gly 
    1160                 1165                 1170             


Pro Ala  Gly Leu Pro Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly 
    1175                 1180                 1185             


Ile Gly  Ile Gly Ala Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys 
    1190                 1195                 1200             


Gly Asp  Arg Gly Phe Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro 
    1205                 1210                 1215             


Gly Ala  Pro Gly Ile Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro 
    1220                 1225                 1230             


Gly Asp  Pro Gly Arg Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro 
    1235                 1240                 1245             


Gly Pro  Ala Gly Pro Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln 
    1250                 1255                 1260             


Gly Asp  Thr Gly Asp Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys 
    1265                 1270                 1275             


Gly Pro  Lys Gly Asp Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro 
    1280                 1285                 1290             


Gly Glu  Leu Gly Leu Lys Gly  Met Arg Gly Glu Pro  Gly Phe Met 
    1295                 1300                 1305             


Gly Thr  Pro Gly Lys Val Gly  Pro Pro Gly Asp Pro  Gly Phe Pro 
    1310                 1315                 1320             


Gly Met  Lys Gly Lys Ala Gly  Pro Arg Gly Ser Ser  Gly Leu Gln 
    1325                 1330                 1335             


Gly Asp  Pro Gly Gln Thr Pro  Thr Ala Glu Ala Val  Gln Val Pro 
    1340                 1345                 1350             


Pro Gly  Pro Leu Gly Leu Pro  Gly Ile Asp Gly Ile  Pro Gly Leu 
    1355                 1360                 1365             


Thr Gly  Asp Pro Gly Ala Gln  Gly Pro Val Gly Leu  Gln Gly Ser 
    1370                 1375                 1380             


Lys Gly  Leu Pro Gly Ile Pro  Gly Lys Asp Gly Pro  Ser Gly Leu 
    1385                 1390                 1395             


Pro Gly  Pro Pro Gly Ala Leu  Gly Asp Pro Gly Leu  Pro Gly Leu 
    1400                 1405                 1410             


Gln Gly  Pro Pro Gly Phe Glu  Gly Ala Pro Gly Gln  Gln Gly Pro 
    1415                 1420                 1425             


Phe Gly  Met Pro Gly Met Pro  Gly Gln Ser Met Arg  Val Gly Tyr 
    1430                 1435                 1440             


Thr Leu  Val Lys His Ser Gln  Ser Glu Gln Val Pro  Pro Cys Pro 
    1445                 1450                 1455             


Ile Gly  Met Ser Gln Leu Trp  Val Gly Tyr Ser Leu  Leu Phe Val 
    1460                 1465                 1470             


Glu Gly  Gln Glu Lys Ala His  Asn Gln Asp Leu Gly  Phe Ala Gly 
    1475                 1480                 1485             


Ser Cys  Leu Pro Arg Phe Ser  Thr Met Pro Phe Ile  Tyr Cys Asn 
    1490                 1495                 1500             


Ile Asn  Glu Val Cys His Tyr  Ala Arg Arg Asn Asp  Lys Ser Tyr 
    1505                 1510                 1515             


Trp Leu  Ser Thr Thr Ala Pro  Ile Pro Met Met Pro  Val Ser Gln 
    1520                 1525                 1530             


Thr Gln  Ile Pro Gln Tyr Ile  Ser Arg Cys Ser Val  Cys Glu Ala 
    1535                 1540                 1545             


Pro Ser  Gln Ala Ile Ala Val  His Ser Gln Asp Ile  Thr Ile Pro 
    1550                 1555                 1560             


Gln Cys  Pro Leu Gly Trp Arg  Ser Leu Trp Ile Gly  Tyr Ser Phe 
    1565                 1570                 1575             


Leu Met  His Thr Ala Ala Gly  Ala Glu Gly Gly Gly  Gln Ser Leu 
    1580                 1585                 1590             


Val Ser  Pro Gly Ser Cys Leu  Glu Asp Phe Arg Ala  Thr Pro Phe 
    1595                 1600                 1605             


Ile Glu  Cys Ser Gly Ala Arg  Gly Thr Cys His Tyr  Phe Ala Asn 
    1610                 1615                 1620             


Lys Tyr  Ser Phe Trp Leu Thr  Thr Val Glu Glu Arg  Gln Gln Phe 
    1625                 1630                 1635             


Gly Glu  Leu Pro Val Ser Glu  Thr Leu Lys Ala Gly  Gln Leu His 
    1640                 1645                 1650             


Thr Arg  Val Ser Arg Cys Gln  Val Cys Met Lys Ser  Leu 
    1655                 1660                 1665     


<210>  2423
<211>  1838
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL5A1__Homo_sapiens__NP_000084

<400>  2423

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  2424
<211>  1499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL5A2__Homo_sapiens__NP_000384

<400>  2424

Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val 
1               5                   10                  15      


Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp 
            20                  25                  30          


Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr 
        35                  40                  45              


Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys 
    50                  55                  60                  


Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu 
65                  70                  75                  80  


Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys 
                85                  90                  95      


Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys 
            100                 105                 110         


Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg 
        115                 120                 125             


Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly 
    130                 135                 140                 


Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile 
145                 150                 155                 160 


Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro 
                165                 170                 175     


Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser 
            180                 185                 190         


Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val 
        195                 200                 205             


Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln 
    210                 215                 220                 


Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly 
225                 230                 235                 240 


Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro 
                245                 250                 255     


Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn 
            260                 265                 270         


Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly 
        275                 280                 285             


Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His 
    290                 295                 300                 


Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys 
305                 310                 315                 320 


Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly 
                325                 330                 335     


Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala 
            340                 345                 350         


Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met 
        355                 360                 365             


Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly 
    370                 375                 380                 


Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro 
385                 390                 395                 400 


Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro 
                405                 410                 415     


Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Ala Lys Gly 
            420                 425                 430         


Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro 
        435                 440                 445             


Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Ile Arg 
    450                 455                 460                 


Gly Gln Pro Gly Asp Pro Gly Val Pro Gly Phe Lys Gly Glu Ala Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro 
                485                 490                 495     


Pro Gly Glu Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Val 
            500                 505                 510         


Gly Pro Pro Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly 
        515                 520                 525             


Phe Pro Gly Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu 
    530                 535                 540                 


Arg Gly Pro Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro 
545                 550                 555                 560 


Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly 
                565                 570                 575     


Asn Pro Gly Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala 
            580                 585                 590         


Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Arg 
        595                 600                 605             


Gly Gln Pro Gly Ser Met Gly Leu Pro Gly Pro Lys Gly Ser Ser Gly 
    610                 615                 620                 


Asp Pro Gly Lys Pro Gly Glu Ala Gly Asn Ala Gly Val Pro Gly Gln 
625                 630                 635                 640 


Arg Gly Ala Pro Gly Lys Asp Gly Glu Val Gly Pro Ser Gly Pro Val 
                645                 650                 655     


Gly Pro Pro Gly Leu Ala Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly 
            660                 665                 670         


Pro Thr Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu 
        675                 680                 685             


Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Asp Pro Gly Ala Val 
    690                 695                 700                 


Gly Pro Leu Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly 
705                 710                 715                 720 


Glu Pro Gly Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly 
                725                 730                 735     


His Gly Pro Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro 
            740                 745                 750         


Gly Asp Thr Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly 
        755                 760                 765             


Ile Ala Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu 
    770                 775                 780                 


Lys Gly Ala Glu Gly Thr Ala Gly Asn Asp Gly Ala Arg Gly Leu Pro 
785                 790                 795                 800 


Gly Pro Leu Gly Pro Pro Gly Pro Ala Gly Pro Thr Gly Glu Lys Gly 
                805                 810                 815     


Glu Pro Gly Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn 
            820                 825                 830         


Pro Gly Ser Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala 
        835                 840                 845             


Gly Pro Gln Gly Pro Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly 
    850                 855                 860                 


Glu Pro Gly Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu 
865                 870                 875                 880 


Ala Gly Ser Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys 
                885                 890                 895     


Gly Gly Arg Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly 
            900                 905                 910         


Ser Ala Gly Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro 
        915                 920                 925             


Ala Gly Pro Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Leu Arg 
    930                 935                 940                 


Gly Asp Pro Gly Ser His Gly Arg Val Gly Asp Arg Gly Pro Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln 
                965                 970                 975     


Pro Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg 
            980                 985                 990         


Gly Ile Val Gly Met Pro Gly Gln  Arg Gly Glu Arg Gly  Met Pro Gly 
        995                 1000                 1005             


Leu Pro  Gly Pro Ala Gly Thr  Pro Gly Lys Val Gly  Pro Thr Gly 
    1010                 1015                 1020             


Ala Thr  Gly Asp Lys Gly Pro  Pro Gly Pro Val Gly  Pro Pro Gly 
    1025                 1030                 1035             


Ser Asn  Gly Pro Val Gly Glu  Pro Gly Pro Glu Gly  Pro Ala Gly 
    1040                 1045                 1050             


Asn Asp  Gly Thr Pro Gly Arg  Asp Gly Ala Val Gly  Glu Arg Gly 
    1055                 1060                 1065             


Asp Arg  Gly Asp Pro Gly Pro  Ala Gly Leu Pro Gly  Ser Gln Gly 
    1070                 1075                 1080             


Ala Pro  Gly Thr Pro Gly Pro  Val Gly Ala Pro Gly  Asp Ala Gly 
    1085                 1090                 1095             


Gln Arg  Gly Asp Pro Gly Ser  Arg Gly Pro Ile Gly  Pro Pro Gly 
    1100                 1105                 1110             


Arg Ala  Gly Lys Arg Gly Leu  Pro Gly Pro Gln Gly  Pro Arg Gly 
    1115                 1120                 1125             


Asp Lys  Gly Asp His Gly Asp  Arg Gly Asp Arg Gly  Gln Lys Gly 
    1130                 1135                 1140             


His Arg  Gly Phe Thr Gly Leu  Gln Gly Leu Pro Gly  Pro Pro Gly 
    1145                 1150                 1155             


Pro Asn  Gly Glu Gln Gly Ser  Ala Gly Ile Pro Gly  Pro Phe Gly 
    1160                 1165                 1170             


Pro Arg  Gly Pro Pro Gly Pro  Val Gly Pro Ser Gly  Lys Glu Gly 
    1175                 1180                 1185             


Asn Pro  Gly Pro Leu Gly Pro  Ile Gly Pro Pro Gly  Val Arg Gly 
    1190                 1195                 1200             


Ser Val  Gly Glu Ala Gly Pro  Glu Gly Pro Pro Gly  Glu Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly His Leu Thr  Ala Ala Leu 
    1220                 1225                 1230             


Gly Asp  Ile Met Gly His Tyr  Asp Glu Ser Met Pro  Asp Pro Leu 
    1235                 1240                 1245             


Pro Glu  Phe Thr Glu Asp Gln  Ala Ala Pro Asp Asp  Lys Asn Lys 
    1250                 1255                 1260             


Thr Asp  Pro Gly Val His Ala  Thr Leu Lys Ser Leu  Ser Ser Gln 
    1265                 1270                 1275             


Ile Glu  Thr Met Arg Ser Pro  Asp Gly Ser Lys Lys  His Pro Ala 
    1280                 1285                 1290             


Arg Thr  Cys Asp Asp Leu Lys  Leu Cys His Ser Ala  Lys Gln Ser 
    1295                 1300                 1305             


Gly Glu  Tyr Trp Ile Asp Pro  Asn Gln Gly Ser Val  Glu Asp Ala 
    1310                 1315                 1320             


Ile Lys  Val Tyr Cys Asn Met  Glu Thr Gly Glu Thr  Cys Ile Ser 
    1325                 1330                 1335             


Ala Asn  Pro Ser Ser Val Pro  Arg Lys Thr Trp Trp  Ala Ser Lys 
    1340                 1345                 1350             


Ser Pro  Asp Asn Lys Pro Val  Trp Tyr Gly Leu Asp  Met Asn Arg 
    1355                 1360                 1365             


Gly Ser  Gln Phe Ala Tyr Gly  Asp His Gln Ser Pro  Asn Thr Ala 
    1370                 1375                 1380             


Ile Thr  Gln Met Thr Phe Leu  Arg Leu Leu Ser Lys  Glu Ala Ser 
    1385                 1390                 1395             


Gln Asn  Ile Thr Tyr Ile Cys  Lys Asn Ser Val Gly  Tyr Met Asp 
    1400                 1405                 1410             


Asp Gln  Ala Lys Asn Leu Lys  Lys Ala Val Val Leu  Lys Gly Ala 
    1415                 1420                 1425             


Asn Asp  Leu Asp Ile Lys Ala  Glu Gly Asn Ile Arg  Phe Arg Tyr 
    1430                 1435                 1440             


Ile Val  Leu Gln Asp Thr Cys  Ser Lys Arg Asn Gly  Asn Val Gly 
    1445                 1450                 1455             


Lys Thr  Val Phe Glu Tyr Arg  Thr Gln Asn Val Ala  Arg Leu Pro 
    1460                 1465                 1470             


Ile Ile  Asp Leu Ala Pro Val  Asp Val Gly Gly Thr  Asp Gln Glu 
    1475                 1480                 1485             


Phe Gly  Val Glu Ile Gly Pro  Val Cys Phe Val 
    1490                 1495                 


<210>  2425
<211>  1745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL5A3__Homo_sapiens__NP_056534

<400>  2425

Met Gly Asn Arg Arg Asp Leu Gly Gln Pro Arg Ala Gly Leu Cys Leu 
1               5                   10                  15      


Leu Leu Ala Ala Leu Gln Leu Leu Pro Gly Thr Gln Ala Asp Pro Val 
            20                  25                  30          


Asp Val Leu Lys Ala Leu Gly Val Gln Gly Gly Gln Ala Gly Val Pro 
        35                  40                  45              


Glu Gly Pro Gly Phe Cys Pro Gln Arg Thr Pro Glu Gly Asp Arg Ala 
    50                  55                  60                  


Phe Arg Ile Gly Gln Ala Ser Thr Leu Gly Ile Pro Thr Trp Glu Leu 
65                  70                  75                  80  


Phe Pro Glu Gly His Phe Pro Glu Asn Phe Ser Leu Leu Ile Thr Leu 
                85                  90                  95      


Arg Gly Gln Pro Ala Asn Gln Ser Val Leu Leu Ser Ile Tyr Asp Glu 
            100                 105                 110         


Arg Gly Ala Arg Gln Leu Gly Leu Ala Leu Gly Pro Ala Leu Gly Leu 
        115                 120                 125             


Leu Gly Asp Pro Phe Arg Pro Leu Pro Gln Gln Val Asn Leu Thr Asp 
    130                 135                 140                 


Gly Arg Trp His Arg Val Ala Val Ser Ile Asp Gly Glu Met Val Thr 
145                 150                 155                 160 


Leu Val Ala Asp Cys Glu Ala Gln Pro Pro Val Leu Gly His Gly Pro 
                165                 170                 175     


Arg Phe Ile Ser Ile Ala Gly Leu Thr Val Leu Gly Thr Gln Asp Leu 
            180                 185                 190         


Gly Glu Lys Thr Phe Glu Gly Asp Ile Gln Glu Leu Leu Ile Ser Pro 
        195                 200                 205             


Asp Pro Gln Ala Ala Phe Gln Ala Cys Glu Arg Tyr Leu Pro Asp Cys 
    210                 215                 220                 


Asp Asn Leu Ala Pro Ala Ala Thr Val Ala Pro Gln Gly Glu Pro Glu 
225                 230                 235                 240 


Thr Pro Arg Pro Arg Arg Lys Gly Lys Gly Lys Gly Arg Lys Lys Gly 
                245                 250                 255     


Arg Gly Arg Lys Gly Lys Gly Arg Lys Lys Asn Lys Glu Ile Trp Thr 
            260                 265                 270         


Ser Ser Pro Pro Pro Asp Ser Ala Glu Asn Gln Thr Ser Thr Asp Ile 
        275                 280                 285             


Pro Lys Thr Glu Thr Pro Ala Pro Asn Leu Pro Pro Thr Pro Thr Pro 
    290                 295                 300                 


Leu Val Val Thr Ser Thr Val Thr Thr Gly Leu Asn Ala Thr Ile Leu 
305                 310                 315                 320 


Glu Arg Ser Leu Asp Pro Asp Ser Gly Thr Glu Leu Gly Thr Leu Glu 
                325                 330                 335     


Thr Lys Ala Ala Arg Glu Asp Glu Glu Gly Asp Asp Ser Thr Met Gly 
            340                 345                 350         


Pro Asp Phe Arg Ala Ala Glu Tyr Pro Ser Arg Thr Gln Phe Gln Ile 
        355                 360                 365             


Phe Pro Gly Ala Gly Glu Lys Gly Ala Lys Gly Glu Pro Ala Val Ile 
    370                 375                 380                 


Glu Lys Gly Gln Gln Phe Glu Gly Pro Pro Gly Ala Pro Gly Pro Gln 
385                 390                 395                 400 


Gly Val Val Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly 
                405                 410                 415     


Asp Pro Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ile Pro Gly Ile 
            420                 425                 430         


Asp Gly Ile Arg Gly Pro Pro Gly Thr Val Ile Met Met Pro Phe Gln 
        435                 440                 445             


Phe Ala Gly Gly Ser Phe Lys Gly Pro Pro Val Ser Phe Gln Gln Ala 
    450                 455                 460                 


Gln Ala Gln Ala Val Leu Gln Gln Thr Gln Leu Ser Met Lys Gly Pro 
465                 470                 475                 480 


Pro Gly Pro Val Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Leu Pro 
                485                 490                 495     


Gly His Pro Gly Leu Lys Gly Glu Glu Gly Ala Glu Gly Pro Gln Gly 
            500                 505                 510         


Pro Arg Gly Leu Gln Gly Pro His Gly Pro Pro Gly Arg Val Gly Lys 
        515                 520                 525             


Met Gly Arg Pro Gly Ala Asp Gly Ala Arg Gly Leu Pro Gly Asp Thr 
    530                 535                 540                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Glu Lys Gly Gln Arg Gly Asp Phe Gly His Val Gly Gln Pro Gly Pro 
                565                 570                 575     


Pro Gly Glu Asp Gly Glu Arg Gly Ala Glu Gly Pro Pro Gly Pro Thr 
            580                 585                 590         


Gly Gln Ala Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly 
        595                 600                 605             


Ser Pro Gly Pro Thr Gly Arg Pro Gly Val Thr Gly Ile Asp Gly Ala 
    610                 615                 620                 


Pro Gly Ala Lys Gly Asn Val Gly Pro Pro Gly Glu Pro Gly Pro Pro 
625                 630                 635                 640 


Gly Gln Gln Gly Asn His Gly Ser Gln Gly Leu Pro Gly Pro Gln Gly 
                645                 650                 655     


Leu Ile Gly Thr Pro Gly Glu Lys Gly Pro Pro Gly Asn Pro Gly Ile 
            660                 665                 670         


Pro Gly Leu Pro Gly Ser Asp Gly Pro Leu Gly His Pro Gly His Glu 
        675                 680                 685             


Gly Pro Thr Gly Glu Lys Gly Ala Gln Gly Pro Pro Gly Ser Ala Gly 
    690                 695                 700                 


Pro Pro Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Thr Ser Gly Asn 
705                 710                 715                 720 


Arg Gly Leu Gln Gly Glu Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                725                 730                 735     


Gly Phe Lys Gly Asp Val Gly Leu Lys Gly Asp Gln Gly Lys Pro Gly 
            740                 745                 750         


Ala Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Gln 
        755                 760                 765             


Ala Gly Gln Ala Gly Glu Glu Gly Pro Pro Gly Ser Ala Gly Glu Lys 
    770                 775                 780                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Pro Gly 
785                 790                 795                 800 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Pro Leu Gly Pro Ile Gly Glu 
                805                 810                 815     


Lys Gly Lys Ser Gly Lys Thr Gly Gln Pro Gly Leu Glu Gly Glu Arg 
            820                 825                 830         


Gly Pro Pro Gly Ser Arg Gly Glu Arg Gly Gln Pro Gly Ala Thr Gly 
        835                 840                 845             


Gln Pro Gly Pro Lys Gly Asp Val Gly Gln Asp Gly Ala Pro Gly Ile 
    850                 855                 860                 


Pro Gly Glu Lys Gly Leu Pro Gly Leu Gln Gly Pro Pro Gly Phe Pro 
865                 870                 875                 880 


Gly Pro Lys Gly Pro Pro Gly His Gln Gly Lys Asp Gly Arg Pro Gly 
                885                 890                 895     


His Pro Gly Gln Arg Gly Glu Leu Gly Phe Gln Gly Gln Thr Gly Pro 
            900                 905                 910         


Pro Gly Pro Ala Gly Val Leu Gly Pro Gln Gly Lys Thr Gly Glu Val 
        915                 920                 925             


Gly Pro Leu Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    930                 935                 940                 


Glu Gln Gly Leu Pro Gly Leu Glu Gly Arg Glu Gly Ala Lys Gly Glu 
945                 950                 955                 960 


Leu Gly Pro Pro Gly Pro Leu Gly Lys Glu Gly Pro Ala Gly Leu Arg 
                965                 970                 975     


Gly Phe Pro Gly Pro Lys Gly Gly Pro Gly Asp Pro Gly Pro Thr Gly 
            980                 985                 990         


Leu Lys Gly Asp Lys Gly Pro Pro  Gly Pro Val Gly Ala  Asn Gly Ser 
        995                 1000                 1005             


Pro Gly  Glu Arg Gly Pro Leu  Gly Pro Ala Gly Gly  Ile Gly Leu 
    1010                 1015                 1020             


Pro Gly  Gln Ser Gly Ser Glu  Gly Pro Val Gly Pro  Ala Gly Lys 
    1025                 1030                 1035             


Lys Gly  Ser Arg Gly Glu Arg  Gly Pro Pro Gly Pro  Thr Gly Lys 
    1040                 1045                 1050             


Asp Gly  Ile Pro Gly Pro Leu  Gly Pro Leu Gly Pro  Pro Gly Ala 
    1055                 1060                 1065             


Ala Gly  Pro Ser Gly Glu Glu  Gly Asp Lys Gly Asp  Val Gly Ala 
    1070                 1075                 1080             


Pro Gly  His Lys Gly Ser Lys  Gly Asp Lys Gly Asp  Ala Gly Pro 
    1085                 1090                 1095             


Pro Gly  Gln Pro Gly Ile Arg  Gly Pro Ala Gly His  Pro Gly Pro 
    1100                 1105                 1110             


Pro Gly  Ala Asp Gly Ala Gln  Gly Arg Arg Gly Pro  Pro Gly Leu 
    1115                 1120                 1125             


Phe Gly  Gln Lys Gly Asp Asp  Gly Val Arg Gly Phe  Val Gly Val 
    1130                 1135                 1140             


Ile Gly  Pro Pro Gly Leu Gln  Gly Leu Pro Gly Pro  Pro Gly Glu 
    1145                 1150                 1155             


Lys Gly  Glu Val Gly Asp Val  Gly Ser Met Gly Pro  His Gly Ala 
    1160                 1165                 1170             


Pro Gly  Pro Arg Gly Pro Gln  Gly Pro Thr Gly Ser  Glu Gly Thr 
    1175                 1180                 1185             


Pro Gly  Leu Pro Gly Gly Val  Gly Gln Pro Gly Ala  Val Gly Glu 
    1190                 1195                 1200             


Lys Gly  Glu Arg Gly Asp Ala  Gly Asp Pro Gly Pro  Pro Gly Ala 
    1205                 1210                 1215             


Pro Gly  Ile Pro Gly Pro Lys  Gly Asp Ile Gly Glu  Lys Gly Asp 
    1220                 1225                 1230             


Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro Gly Lys  Lys Gly Pro 
    1235                 1240                 1245             


Pro Gly  Glu Asp Gly Ala Lys  Gly Ser Val Gly Pro  Thr Gly Leu 
    1250                 1255                 1260             


Pro Gly  Asp Leu Gly Pro Pro  Gly Asp Pro Gly Val  Ser Gly Ile 
    1265                 1270                 1275             


Asp Gly  Ser Pro Gly Glu Lys  Gly Asp Pro Gly Asp  Val Gly Gly 
    1280                 1285                 1290             


Pro Gly  Pro Pro Gly Ala Ser  Gly Glu Pro Gly Ala  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Lys Arg Gly Pro Ser  Gly His Met Gly Arg  Glu Gly Arg 
    1310                 1315                 1320             


Glu Gly  Glu Lys Gly Ala Lys  Gly Glu Pro Gly Pro  Asp Gly Pro 
    1325                 1330                 1335             


Pro Gly  Arg Thr Gly Pro Met  Gly Ala Arg Gly Pro  Pro Gly Arg 
    1340                 1345                 1350             


Val Gly  Pro Glu Gly Leu Arg  Gly Ile Pro Gly Pro  Val Gly Glu 
    1355                 1360                 1365             


Pro Gly  Leu Leu Gly Ala Pro  Gly Gln Met Gly Pro  Pro Gly Pro 
    1370                 1375                 1380             


Leu Gly  Pro Ser Gly Leu Pro  Gly Leu Lys Gly Asp  Thr Gly Pro 
    1385                 1390                 1395             


Lys Gly  Glu Lys Gly His Ile  Gly Leu Ile Gly Leu  Ile Gly Pro 
    1400                 1405                 1410             


Pro Gly  Glu Ala Gly Glu Lys  Gly Asp Gln Gly Leu  Pro Gly Val 
    1415                 1420                 1425             


Gln Gly  Pro Pro Gly Pro Lys  Gly Asp Pro Gly Pro  Pro Gly Pro 
    1430                 1435                 1440             


Ile Gly  Ser Leu Gly His Pro  Gly Pro Pro Gly Val  Ala Gly Pro 
    1445                 1450                 1455             


Leu Gly  Gln Lys Gly Ser Lys  Gly Ser Pro Gly Ser  Met Gly Pro 
    1460                 1465                 1470             


Arg Gly  Asp Thr Gly Pro Ala  Gly Pro Pro Gly Pro  Pro Gly Ala 
    1475                 1480                 1485             


Pro Ala  Glu Leu His Gly Leu  Arg Arg Arg Arg Arg  Phe Val Pro 
    1490                 1495                 1500             


Val Pro  Leu Pro Val Val Glu  Gly Gly Leu Glu Glu  Val Leu Ala 
    1505                 1510                 1515             


Ser Leu  Thr Ser Leu Ser Leu  Glu Leu Glu Gln Leu  Arg Arg Pro 
    1520                 1525                 1530             


Pro Gly  Thr Ala Glu Arg Pro  Gly Leu Val Cys His  Glu Leu His 
    1535                 1540                 1545             


Arg Asn  His Pro His Leu Pro  Asp Gly Glu Tyr Trp  Ile Asp Pro 
    1550                 1555                 1560             


Asn Gln  Gly Cys Ala Arg Asp  Ser Phe Arg Val Phe  Cys Asn Phe 
    1565                 1570                 1575             


Thr Ala  Gly Gly Glu Thr Cys  Leu Tyr Pro Asp Lys  Lys Phe Glu 
    1580                 1585                 1590             


Ile Val  Lys Leu Ala Ser Trp  Ser Lys Glu Lys Pro  Gly Gly Trp 
    1595                 1600                 1605             


Tyr Ser  Thr Phe Arg Arg Gly  Lys Lys Phe Ser Tyr  Val Asp Ala 
    1610                 1615                 1620             


Asp Gly  Ser Pro Val Asn Val  Val Gln Leu Asn Phe  Leu Lys Leu 
    1625                 1630                 1635             


Leu Ser  Ala Thr Ala Arg Gln  Asn Phe Thr Tyr Ser  Cys Gln Asn 
    1640                 1645                 1650             


Ala Ala  Ala Trp Leu Asp Glu  Ala Thr Gly Asp Tyr  Ser His Ser 
    1655                 1660                 1665             


Ala Arg  Phe Leu Gly Thr Asn  Gly Glu Glu Leu Ser  Phe Asn Gln 
    1670                 1675                 1680             


Thr Thr  Ala Ala Thr Val Ser  Val Pro Gln Asp Gly  Cys Arg Leu 
    1685                 1690                 1695             


Arg Lys  Gly Gln Thr Lys Thr  Leu Phe Glu Phe Ser  Ser Ser Arg 
    1700                 1705                 1710             


Ala Gly  Phe Leu Pro Leu Trp  Asp Val Ala Ala Thr  Asp Phe Gly 
    1715                 1720                 1725             


Gln Thr  Asn Gln Lys Phe Gly  Phe Glu Leu Gly Pro  Val Cys Phe 
    1730                 1735                 1740             


Ser Ser  
    1745 


<210>  2426
<211>  1028
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL6A1__Homo_sapiens__NP_001839

<400>  2426

Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu 
                325                 330                 335     


Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp 
            340                 345                 350         


Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly 
        355                 360                 365             


Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg 
    370                 375                 380                 


Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro 
385                 390                 395                 400 


Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly 
                405                 410                 415     


Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro 
            420                 425                 430         


Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala 
        435                 440                 445             


Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly 
    450                 455                 460                 


Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp 
465                 470                 475                 480 


Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala 
                485                 490                 495     


Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly 
            500                 505                 510         


Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro 
        515                 520                 525             


Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro 
                565                 570                 575     


Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp 
            580                 585                 590         


Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu 
        595                 600                 605             


Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys 
625                 630                 635                 640 


Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly 
                645                 650                 655     


Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu 
            660                 665                 670         


His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys 
        675                 680                 685             


Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly 
    690                 695                 700                 


Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn 
705                 710                 715                 720 


Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg 
                725                 730                 735     


Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val 
            740                 745                 750         


Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln 
        755                 760                 765             


Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro 
    770                 775                 780                 


Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala 
785                 790                 795                 800 


Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro 
                805                 810                 815     


Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile 
            820                 825                 830         


Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr 
        835                 840                 845             


Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg 
    850                 855                 860                 


Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly 
865                 870                 875                 880 


Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn 
                885                 890                 895     


Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp 
            900                 905                 910         


Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg 
        915                 920                 925             


Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp 
    930                 935                 940                 


Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln 
945                 950                 955                 960 


Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg 
                965                 970                 975     


Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala 
            980                 985                 990         


Glu Tyr Asp Val Ala Tyr Gly Glu  Ser His Leu Phe Arg  Val Pro Ser 
        995                 1000                 1005             


Tyr Gln  Ala Leu Leu Arg Gly  Val Phe His Gln Thr  Val Ser Arg 
    1010                 1015                 1020             


Lys Val  Ala Leu Gly 
    1025             


<210>  2427
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL6A2__Homo_sapiens__NP_478054

<400>  2427

Met Leu Gln Gly Thr Cys Ser Val Leu Leu Leu Trp Gly Ile Leu Gly 
1               5                   10                  15      


Ala Ile Gln Ala Gln Gln Gln Glu Val Ile Ser Pro Asp Thr Thr Glu 
            20                  25                  30          


Arg Asn Asn Asn Cys Pro Glu Lys Thr Asp Cys Pro Ile His Val Tyr 
        35                  40                  45              


Phe Val Leu Asp Thr Ser Glu Ser Val Thr Met Gln Ser Pro Thr Asp 
    50                  55                  60                  


Ile Leu Leu Phe His Met Lys Gln Phe Val Pro Gln Phe Ile Ser Gln 
65                  70                  75                  80  


Leu Gln Asn Glu Phe Tyr Leu Asp Gln Val Ala Leu Ser Trp Arg Tyr 
                85                  90                  95      


Gly Gly Leu His Phe Ser Asp Gln Val Glu Val Phe Ser Pro Pro Gly 
            100                 105                 110         


Ser Asp Arg Ala Ser Phe Ile Lys Asn Leu Gln Gly Ile Ser Ser Phe 
        115                 120                 125             


Arg Arg Gly Thr Phe Thr Asp Cys Ala Leu Ala Asn Met Thr Glu Gln 
    130                 135                 140                 


Ile Arg Gln Asp Arg Ser Lys Gly Thr Val His Phe Ala Val Val Ile 
145                 150                 155                 160 


Thr Asp Gly His Val Thr Gly Ser Pro Cys Gly Gly Ile Lys Leu Gln 
                165                 170                 175     


Ala Glu Arg Ala Arg Glu Glu Gly Ile Arg Leu Phe Ala Val Ala Pro 
            180                 185                 190         


Asn Gln Asn Leu Lys Glu Gln Gly Leu Arg Asp Ile Ala Ser Thr Pro 
        195                 200                 205             


His Glu Leu Tyr Arg Asn Asp Tyr Ala Thr Met Leu Pro Asp Ser Thr 
    210                 215                 220                 


Glu Ile Asp Gln Asp Thr Ile Asn Arg Ile Ile Lys Val Met Lys His 
225                 230                 235                 240 


Glu Ala Tyr Gly Glu Cys Tyr Lys Val Ser Cys Leu Glu Ile Pro Gly 
                245                 250                 255     


Pro Ser Gly Pro Lys Gly Tyr Arg Gly Gln Lys Gly Ala Lys Gly Asn 
            260                 265                 270         


Met Gly Glu Pro Gly Glu Pro Gly Gln Lys Gly Arg Gln Gly Asp Pro 
        275                 280                 285             


Gly Ile Glu Gly Pro Ile Gly Phe Pro Gly Pro Lys Gly Val Pro Gly 
    290                 295                 300                 


Phe Lys Gly Glu Lys Gly Glu Phe Gly Ala Asp Gly Arg Lys Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Ala Gly Lys Asn Gly Thr Asp Gly Gln Lys Gly Lys Leu 
                325                 330                 335     


Gly Arg Ile Gly Pro Pro Gly Cys Lys Gly Asp Pro Gly Asn Arg Gly 
            340                 345                 350         


Pro Asp Gly Tyr Pro Gly Glu Ala Gly Ser Pro Gly Glu Arg Gly Asp 
        355                 360                 365             


Gln Gly Gly Lys Gly Asp Pro Gly Arg Pro Gly Arg Arg Gly Pro Pro 
    370                 375                 380                 


Gly Glu Ile Gly Ala Lys Gly Ser Lys Gly Tyr Gln Gly Asn Ser Gly 
385                 390                 395                 400 


Ala Pro Gly Ser Pro Gly Val Lys Gly Ala Lys Gly Gly Pro Gly Pro 
                405                 410                 415     


Arg Gly Pro Lys Gly Glu Pro Gly Arg Arg Gly Asp Pro Gly Thr Lys 
            420                 425                 430         


Gly Ser Pro Gly Ser Asp Gly Pro Lys Gly Glu Lys Gly Asp Pro Gly 
        435                 440                 445             


Pro Glu Gly Pro Arg Gly Leu Ala Gly Glu Val Gly Asn Lys Gly Ala 
    450                 455                 460                 


Lys Gly Asp Arg Gly Leu Pro Gly Pro Arg Gly Pro Gln Gly Ala Leu 
465                 470                 475                 480 


Gly Glu Pro Gly Lys Gln Gly Ser Arg Gly Asp Pro Gly Asp Ala Gly 
                485                 490                 495     


Pro Arg Gly Asp Ser Gly Gln Pro Gly Pro Lys Gly Asp Pro Gly Arg 
            500                 505                 510         


Pro Gly Phe Ser Tyr Pro Gly Pro Arg Gly Ala Pro Gly Glu Lys Gly 
        515                 520                 525             


Glu Pro Gly Pro Arg Gly Pro Glu Gly Gly Arg Gly Asp Phe Gly Leu 
    530                 535                 540                 


Lys Gly Glu Pro Gly Arg Lys Gly Glu Lys Gly Glu Pro Ala Asp Pro 
545                 550                 555                 560 


Gly Pro Pro Gly Glu Pro Gly Pro Arg Gly Pro Arg Gly Val Pro Gly 
                565                 570                 575     


Pro Glu Gly Glu Pro Gly Pro Pro Gly Asp Pro Gly Leu Thr Glu Cys 
            580                 585                 590         


Asp Val Met Thr Tyr Val Arg Glu Thr Cys Gly Cys Cys Asp Cys Glu 
        595                 600                 605             


Lys Arg Cys Gly Ala Leu Asp Val Val Phe Val Ile Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Tyr Thr Asn Phe Thr Leu Glu Lys Asn Phe Val Ile Asn 
625                 630                 635                 640 


Val Val Asn Arg Leu Gly Ala Ile Ala Lys Asp Pro Lys Ser Glu Thr 
                645                 650                 655     


Gly Thr Arg Val Gly Val Val Gln Tyr Ser His Glu Gly Thr Phe Glu 
            660                 665                 670         


Ala Ile Gln Leu Asp Asp Glu Arg Ile Asp Ser Leu Ser Ser Phe Lys 
        675                 680                 685             


Glu Ala Val Lys Asn Leu Glu Trp Ile Ala Gly Gly Thr Trp Thr Pro 
    690                 695                 700                 


Ser Ala Leu Lys Phe Ala Tyr Asp Arg Leu Ile Lys Glu Ser Arg Arg 
705                 710                 715                 720 


Gln Lys Thr Arg Val Phe Ala Val Val Ile Thr Asp Gly Arg His Asp 
                725                 730                 735     


Pro Arg Asp Asp Asp Leu Asn Leu Arg Ala Leu Cys Asp Arg Asp Val 
            740                 745                 750         


Thr Val Thr Ala Ile Gly Ile Gly Asp Met Phe His Glu Lys His Glu 
        755                 760                 765             


Ser Glu Asn Leu Tyr Ser Ile Ala Cys Asp Lys Pro Gln Gln Val Arg 
    770                 775                 780                 


Asn Met Thr Leu Phe Ser Asp Leu Val Ala Glu Lys Phe Ile Asp Asp 
785                 790                 795                 800 


Met Glu Asp Val Leu Cys Pro Asp Pro Gln Ile Val Cys Pro Asp Leu 
                805                 810                 815     


Pro Cys Gln Thr Asp Ala Pro Trp Pro Gly Gly Glu Pro Pro Val Thr 
            820                 825                 830         


Phe Leu Arg Thr Glu Glu Gly Pro Asp Ala Thr Phe Pro Arg Thr Ile 
        835                 840                 845             


Pro Leu Ile Gln Gln Leu Leu Asn Ala Thr Glu Leu Thr Gln Asp Pro 
    850                 855                 860                 


Ala Ala Tyr Ser Gln Leu Val Ala Val Leu Val Tyr Thr Ala Glu Arg 
865                 870                 875                 880 


Ala Lys Phe Ala Thr Gly Val Glu Arg Gln Asp Trp Met Glu Leu Phe 
                885                 890                 895     


Ile Asp Thr Phe Lys Leu Val His Arg Asp Ile Val Gly Asp Pro Glu 
            900                 905                 910         


Thr Ala Leu Ala Leu Cys 
        915             


<210>  2428
<211>  3177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL6A3__Homo_sapiens__NP_004360

<400>  2428

Met Arg Lys His Arg His Leu Pro Leu Val Ala Val Phe Cys Leu Phe 
1               5                   10                  15      


Leu Ser Gly Phe Pro Thr Thr His Ala Gln Gln Gln Gln Ala Asp Val 
            20                  25                  30          


Lys Asn Gly Ala Ala Ala Asp Ile Ile Phe Leu Val Asp Ser Ser Trp 
        35                  40                  45              


Thr Ile Gly Glu Glu His Phe Gln Leu Val Arg Glu Phe Leu Tyr Asp 
    50                  55                  60                  


Val Val Lys Ser Leu Ala Val Gly Glu Asn Asp Phe His Phe Ala Leu 
65                  70                  75                  80  


Val Gln Phe Asn Gly Asn Pro His Thr Glu Phe Leu Leu Asn Thr Tyr 
                85                  90                  95      


Arg Thr Lys Gln Glu Val Leu Ser His Ile Ser Asn Met Ser Tyr Ile 
            100                 105                 110         


Gly Gly Thr Asn Gln Thr Gly Lys Gly Leu Glu Tyr Ile Met Gln Ser 
        115                 120                 125             


His Leu Thr Lys Ala Ala Gly Ser Arg Ala Gly Asp Gly Val Pro Gln 
    130                 135                 140                 


Val Ile Val Val Leu Thr Asp Gly His Ser Lys Asp Gly Leu Ala Leu 
145                 150                 155                 160 


Pro Ser Ala Glu Leu Lys Ser Ala Asp Val Asn Val Phe Ala Ile Gly 
                165                 170                 175     


Val Glu Asp Ala Asp Glu Gly Ala Leu Lys Glu Ile Ala Ser Glu Pro 
            180                 185                 190         


Leu Asn Met His Met Phe Asn Leu Glu Asn Phe Thr Ser Leu His Asp 
        195                 200                 205             


Ile Val Gly Asn Leu Val Ser Cys Val His Ser Ser Val Ser Pro Glu 
    210                 215                 220                 


Arg Ala Gly Asp Thr Glu Thr Leu Lys Asp Ile Thr Ala Gln Asp Ser 
225                 230                 235                 240 


Ala Asp Ile Ile Phe Leu Ile Asp Gly Ser Asn Asn Thr Gly Ser Val 
                245                 250                 255     


Asn Phe Ala Val Ile Leu Asp Phe Leu Val Asn Leu Leu Glu Lys Leu 
            260                 265                 270         


Pro Ile Gly Thr Gln Gln Ile Arg Val Gly Val Val Gln Phe Ser Asp 
        275                 280                 285             


Glu Pro Arg Thr Met Phe Ser Leu Asp Thr Tyr Ser Thr Lys Ala Gln 
    290                 295                 300                 


Val Leu Gly Ala Val Lys Ala Leu Gly Phe Ala Gly Gly Glu Leu Ala 
305                 310                 315                 320 


Asn Ile Gly Leu Ala Leu Asp Phe Val Val Glu Asn His Phe Thr Arg 
                325                 330                 335     


Ala Gly Gly Ser Arg Val Glu Glu Gly Val Pro Gln Val Leu Val Leu 
            340                 345                 350         


Ile Ser Ala Gly Pro Ser Ser Asp Glu Ile Arg Tyr Gly Val Val Ala 
        355                 360                 365             


Leu Lys Gln Ala Ser Val Phe Ser Phe Gly Leu Gly Ala Gln Ala Ala 
    370                 375                 380                 


Ser Arg Ala Glu Leu Gln His Ile Ala Thr Asp Asp Asn Leu Val Phe 
385                 390                 395                 400 


Thr Val Pro Glu Phe Arg Ser Phe Gly Asp Leu Gln Glu Lys Leu Leu 
                405                 410                 415     


Pro Tyr Ile Val Gly Val Ala Gln Arg His Ile Val Leu Lys Pro Pro 
            420                 425                 430         


Thr Ile Val Thr Gln Val Ile Glu Val Asn Lys Arg Asp Ile Val Phe 
        435                 440                 445             


Leu Val Asp Gly Ser Ser Ala Leu Gly Leu Ala Asn Phe Asn Ala Ile 
    450                 455                 460                 


Arg Asp Phe Ile Ala Lys Val Ile Gln Arg Leu Glu Ile Gly Gln Asp 
465                 470                 475                 480 


Leu Ile Gln Val Ala Val Ala Gln Tyr Ala Asp Thr Val Arg Pro Glu 
                485                 490                 495     


Phe Tyr Phe Asn Thr His Pro Thr Lys Arg Glu Val Ile Thr Ala Val 
            500                 505                 510         


Arg Lys Met Lys Pro Leu Asp Gly Ser Ala Leu Tyr Thr Gly Ser Ala 
        515                 520                 525             


Leu Asp Phe Val Arg Asn Asn Leu Phe Thr Ser Ser Ala Gly Tyr Arg 
    530                 535                 540                 


Ala Ala Glu Gly Ile Pro Lys Leu Leu Val Leu Ile Thr Gly Gly Lys 
545                 550                 555                 560 


Ser Leu Asp Glu Ile Ser Gln Pro Ala Gln Glu Leu Lys Arg Ser Ser 
                565                 570                 575     


Ile Met Ala Phe Ala Ile Gly Asn Lys Gly Ala Asp Gln Ala Glu Leu 
            580                 585                 590         


Glu Glu Ile Ala Phe Asp Ser Ser Leu Val Phe Ile Pro Ala Glu Phe 
        595                 600                 605             


Arg Ala Ala Pro Leu Gln Gly Met Leu Pro Gly Leu Leu Ala Pro Leu 
    610                 615                 620                 


Arg Thr Leu Ser Gly Thr Pro Glu Val His Ser Asn Lys Arg Asp Ile 
625                 630                 635                 640 


Ile Phe Leu Leu Asp Gly Ser Ala Asn Val Gly Lys Thr Asn Phe Pro 
                645                 650                 655     


Tyr Val Arg Asp Phe Val Met Asn Leu Val Asn Ser Leu Asp Ile Gly 
            660                 665                 670         


Asn Asp Asn Ile Arg Val Gly Leu Val Gln Phe Ser Asp Thr Pro Val 
        675                 680                 685             


Thr Glu Phe Ser Leu Asn Thr Tyr Gln Thr Lys Ser Asp Ile Leu Gly 
    690                 695                 700                 


His Leu Arg Gln Leu Gln Leu Gln Gly Gly Ser Gly Leu Asn Thr Gly 
705                 710                 715                 720 


Ser Ala Leu Ser Tyr Val Tyr Ala Asn His Phe Thr Glu Ala Gly Gly 
                725                 730                 735     


Ser Arg Ile Arg Glu His Val Pro Gln Leu Leu Leu Leu Leu Thr Ala 
            740                 745                 750         


Gly Gln Ser Glu Asp Ser Tyr Leu Gln Ala Ala Asn Ala Leu Thr Arg 
        755                 760                 765             


Ala Gly Ile Leu Thr Phe Cys Val Gly Ala Ser Gln Ala Asn Lys Ala 
    770                 775                 780                 


Glu Leu Glu Gln Ile Ala Phe Asn Pro Ser Leu Val Tyr Leu Met Asp 
785                 790                 795                 800 


Asp Phe Ser Ser Leu Pro Ala Leu Pro Gln Gln Leu Ile Gln Pro Leu 
                805                 810                 815     


Thr Thr Tyr Val Ser Gly Gly Val Glu Glu Val Pro Leu Ala Gln Pro 
            820                 825                 830         


Glu Ser Lys Arg Asp Ile Leu Phe Leu Phe Asp Gly Ser Ala Asn Leu 
        835                 840                 845             


Val Gly Gln Phe Pro Val Val Arg Asp Phe Leu Tyr Lys Ile Ile Asp 
    850                 855                 860                 


Glu Leu Asn Val Lys Pro Glu Gly Thr Arg Ile Ala Val Ala Gln Tyr 
865                 870                 875                 880 


Ser Asp Asp Val Lys Val Glu Ser Arg Phe Asp Glu His Gln Ser Lys 
                885                 890                 895     


Pro Glu Ile Leu Asn Leu Val Lys Arg Met Lys Ile Lys Thr Gly Lys 
            900                 905                 910         


Ala Leu Asn Leu Gly Tyr Ala Leu Asp Tyr Ala Gln Arg Tyr Ile Phe 
        915                 920                 925             


Val Lys Ser Ala Gly Ser Arg Ile Glu Asp Gly Val Leu Gln Phe Leu 
    930                 935                 940                 


Val Leu Leu Val Ala Gly Arg Ser Ser Asp Arg Val Asp Gly Pro Ala 
945                 950                 955                 960 


Ser Asn Leu Lys Gln Ser Gly Val Val Pro Phe Ile Phe Gln Ala Lys 
                965                 970                 975     


Asn Ala Asp Pro Ala Glu Leu Glu Gln Ile Val Leu Ser Pro Ala Phe 
            980                 985                 990         


Ile Leu Ala Ala Glu Ser Leu Pro  Lys Ile Gly Asp Leu  His Pro Gln 
        995                 1000                 1005             


Ile Val  Asn Leu Leu Lys Ser  Val His Asn Gly Ala  Pro Ala Pro 
    1010                 1015                 1020             


Val Ser  Gly Glu Lys Asp Val  Val Phe Leu Leu Asp  Gly Ser Glu 
    1025                 1030                 1035             


Gly Val  Arg Ser Gly Phe Pro  Leu Leu Lys Glu Phe  Val Gln Arg 
    1040                 1045                 1050             


Val Val  Glu Ser Leu Asp Val  Gly Gln Asp Arg Val  Arg Val Ala 
    1055                 1060                 1065             


Val Val  Gln Tyr Ser Asp Arg  Thr Arg Pro Glu Phe  Tyr Leu Asn 
    1070                 1075                 1080             


Ser Tyr  Met Asn Lys Gln Asp  Val Val Asn Ala Val  Arg Gln Leu 
    1085                 1090                 1095             


Thr Leu  Leu Gly Gly Pro Thr  Pro Asn Thr Gly Ala  Ala Leu Glu 
    1100                 1105                 1110             


Phe Val  Leu Arg Asn Ile Leu  Val Ser Ser Ala Gly  Ser Arg Ile 
    1115                 1120                 1125             


Thr Glu  Gly Val Pro Gln Leu  Leu Ile Val Leu Thr  Ala Asp Arg 
    1130                 1135                 1140             


Ser Gly  Asp Asp Val Arg Asn  Pro Ser Val Val Val  Lys Arg Gly 
    1145                 1150                 1155             


Gly Ala  Val Pro Ile Gly Ile  Gly Ile Gly Asn Ala  Asp Ile Thr 
    1160                 1165                 1170             


Glu Met  Gln Thr Ile Ser Phe  Ile Pro Asp Phe Ala  Val Ala Ile 
    1175                 1180                 1185             


Pro Thr  Phe Arg Gln Leu Gly  Thr Val Gln Gln Val  Ile Ser Glu 
    1190                 1195                 1200             


Arg Val  Thr Gln Leu Thr Arg  Glu Glu Leu Ser Arg  Leu Gln Pro 
    1205                 1210                 1215             


Val Leu  Gln Pro Leu Pro Ser  Pro Gly Val Gly Gly  Lys Arg Asp 
    1220                 1225                 1230             


Val Val  Phe Leu Ile Asp Gly  Ser Gln Ser Ala Gly  Pro Glu Phe 
    1235                 1240                 1245             


Gln Tyr  Val Arg Thr Leu Ile  Glu Arg Leu Val Asp  Tyr Leu Asp 
    1250                 1255                 1260             


Val Gly  Phe Asp Thr Thr Arg  Val Ala Val Ile Gln  Phe Ser Asp 
    1265                 1270                 1275             


Asp Pro  Lys Val Glu Phe Leu  Leu Asn Ala His Ser  Ser Lys Asp 
    1280                 1285                 1290             


Glu Val  Gln Asn Ala Val Gln  Arg Leu Arg Pro Lys  Gly Gly Arg 
    1295                 1300                 1305             


Gln Ile  Asn Val Gly Asn Ala  Leu Glu Tyr Val Ser  Arg Asn Ile 
    1310                 1315                 1320             


Phe Lys  Arg Pro Leu Gly Ser  Arg Ile Glu Glu Gly  Val Pro Gln 
    1325                 1330                 1335             


Phe Leu  Val Leu Ile Ser Ser  Gly Lys Ser Asp Asp  Glu Val Asp 
    1340                 1345                 1350             


Asp Pro  Ala Val Glu Leu Lys  Gln Phe Gly Val Ala  Pro Phe Thr 
    1355                 1360                 1365             


Ile Ala  Arg Asn Ala Asp Gln  Glu Glu Leu Val Lys  Ile Ser Leu 
    1370                 1375                 1380             


Ser Pro  Glu Tyr Val Phe Ser  Val Ser Thr Phe Arg  Glu Leu Pro 
    1385                 1390                 1395             


Ser Leu  Glu Gln Lys Leu Leu  Thr Pro Ile Thr Thr  Leu Thr Ser 
    1400                 1405                 1410             


Glu Gln  Ile Gln Lys Leu Leu  Ala Ser Thr Arg Tyr  Pro Pro Pro 
    1415                 1420                 1425             


Ala Val  Glu Ser Asp Ala Ala  Asp Ile Val Phe Leu  Ile Asp Ser 
    1430                 1435                 1440             


Ser Glu  Gly Val Arg Pro Asp  Gly Phe Ala His Ile  Arg Asp Phe 
    1445                 1450                 1455             


Val Ser  Arg Ile Val Arg Arg  Leu Asn Ile Gly Pro  Ser Lys Val 
    1460                 1465                 1470             


Arg Val  Gly Val Val Gln Phe  Ser Asn Asp Val Phe  Pro Glu Phe 
    1475                 1480                 1485             


Tyr Leu  Lys Thr Tyr Arg Ser  Gln Ala Pro Val Leu  Asp Ala Ile 
    1490                 1495                 1500             


Arg Arg  Leu Arg Leu Arg Gly  Gly Ser Pro Leu Asn  Thr Gly Lys 
    1505                 1510                 1515             


Ala Leu  Glu Phe Val Ala Arg  Asn Leu Phe Val Lys  Ser Ala Gly 
    1520                 1525                 1530             


Ser Arg  Ile Glu Asp Gly Val  Pro Gln His Leu Val  Leu Val Leu 
    1535                 1540                 1545             


Gly Gly  Lys Ser Gln Asp Asp  Val Ser Arg Phe Ala  Gln Val Ile 
    1550                 1555                 1560             


Arg Ser  Ser Gly Ile Val Ser  Leu Gly Val Gly Asp  Arg Asn Ile 
    1565                 1570                 1575             


Asp Arg  Thr Glu Leu Gln Thr  Ile Thr Asn Asp Pro  Arg Leu Val 
    1580                 1585                 1590             


Phe Thr  Val Arg Glu Phe Arg  Glu Leu Pro Asn Ile  Glu Glu Arg 
    1595                 1600                 1605             


Ile Met  Asn Ser Phe Gly Pro  Ser Ala Ala Thr Pro  Ala Pro Pro 
    1610                 1615                 1620             


Gly Val  Asp Thr Pro Pro Pro  Ser Arg Pro Glu Lys  Lys Lys Ala 
    1625                 1630                 1635             


Asp Ile  Val Phe Leu Leu Asp  Gly Ser Ile Asn Phe  Arg Arg Asp 
    1640                 1645                 1650             


Ser Phe  Gln Glu Val Leu Arg  Phe Val Ser Glu Ile  Val Asp Thr 
    1655                 1660                 1665             


Val Tyr  Glu Asp Gly Asp Ser  Ile Gln Val Gly Leu  Val Gln Tyr 
    1670                 1675                 1680             


Asn Ser  Asp Pro Thr Asp Glu  Phe Phe Leu Lys Asp  Phe Ser Thr 
    1685                 1690                 1695             


Lys Arg  Gln Ile Ile Asp Ala  Ile Asn Lys Val Val  Tyr Lys Gly 
    1700                 1705                 1710             


Gly Arg  His Ala Asn Thr Lys  Val Gly Leu Glu His  Leu Arg Val 
    1715                 1720                 1725             


Asn His  Phe Val Pro Glu Ala  Gly Ser Arg Leu Asp  Gln Arg Val 
    1730                 1735                 1740             


Pro Gln  Ile Ala Phe Val Ile  Thr Gly Gly Lys Ser  Val Glu Asp 
    1745                 1750                 1755             


Ala Gln  Asp Val Ser Leu Ala  Leu Thr Gln Arg Gly  Val Lys Val 
    1760                 1765                 1770             


Phe Ala  Val Gly Val Arg Asn  Ile Asp Ser Glu Glu  Val Gly Lys 
    1775                 1780                 1785             


Ile Ala  Ser Asn Ser Ala Thr  Ala Phe Arg Val Gly  Asn Val Gln 
    1790                 1795                 1800             


Glu Leu  Ser Glu Leu Ser Glu  Gln Val Leu Glu Thr  Leu His Asp 
    1805                 1810                 1815             


Ala Met  His Glu Thr Leu Cys  Pro Gly Val Thr Asp  Ala Ala Lys 
    1820                 1825                 1830             


Ala Cys  Asn Leu Asp Val Ile  Leu Gly Phe Asp Gly  Ser Arg Asp 
    1835                 1840                 1845             


Gln Asn  Val Phe Val Ala Gln  Lys Gly Phe Glu Ser  Lys Val Asp 
    1850                 1855                 1860             


Ala Ile  Leu Asn Arg Ile Ser  Gln Met His Arg Val  Ser Cys Ser 
    1865                 1870                 1875             


Gly Gly  Arg Ser Pro Thr Val  Arg Val Ser Val Val  Ala Asn Thr 
    1880                 1885                 1890             


Pro Ser  Gly Pro Val Glu Ala  Phe Asp Phe Asp Glu  Tyr Gln Pro 
    1895                 1900                 1905             


Glu Met  Leu Glu Lys Phe Arg  Asn Met Arg Ser Gln  His Pro Tyr 
    1910                 1915                 1920             


Val Leu  Thr Glu Asp Thr Leu  Lys Val Tyr Leu Asn  Lys Phe Arg 
    1925                 1930                 1935             


Gln Ser  Ser Pro Asp Ser Val  Lys Val Val Ile His  Phe Thr Asp 
    1940                 1945                 1950             


Gly Ala  Asp Gly Asp Leu Ala  Asp Leu His Arg Ala  Ser Glu Asn 
    1955                 1960                 1965             


Leu Arg  Gln Glu Gly Val Arg  Ala Leu Ile Leu Val  Gly Leu Glu 
    1970                 1975                 1980             


Arg Val  Val Asn Leu Glu Arg  Leu Met His Leu Glu  Phe Gly Arg 
    1985                 1990                 1995             


Gly Phe  Met Tyr Asp Arg Pro  Leu Arg Leu Asn Leu  Leu Asp Leu 
    2000                 2005                 2010             


Asp Tyr  Glu Leu Ala Glu Gln  Leu Asp Asn Ile Ala  Glu Lys Ala 
    2015                 2020                 2025             


Cys Cys  Gly Val Pro Cys Lys  Cys Ser Gly Gln Arg  Gly Asp Arg 
    2030                 2035                 2040             


Gly Pro  Ile Gly Ser Ile Gly  Pro Lys Gly Ile Pro  Gly Glu Asp 
    2045                 2050                 2055             


Gly Tyr  Arg Gly Tyr Pro Gly  Asp Glu Gly Gly Pro  Gly Glu Arg 
    2060                 2065                 2070             


Gly Pro  Pro Gly Val Asn Gly  Thr Gln Gly Phe Gln  Gly Cys Pro 
    2075                 2080                 2085             


Gly Gln  Arg Gly Val Lys Gly  Ser Arg Gly Phe Pro  Gly Glu Lys 
    2090                 2095                 2100             


Gly Glu  Val Gly Glu Ile Gly  Leu Asp Gly Leu Asp  Gly Glu Asp 
    2105                 2110                 2115             


Gly Asp  Lys Gly Leu Pro Gly  Ser Ser Gly Glu Lys  Gly Asn Pro 
    2120                 2125                 2130             


Gly Arg  Arg Gly Asp Lys Gly  Pro Arg Gly Glu Lys  Gly Glu Arg 
    2135                 2140                 2145             


Gly Asp  Val Gly Ile Arg Gly  Asp Pro Gly Asn Pro  Gly Gln Asp 
    2150                 2155                 2160             


Ser Gln  Glu Arg Gly Pro Lys  Gly Glu Thr Gly Asp  Leu Gly Pro 
    2165                 2170                 2175             


Met Gly  Val Pro Gly Arg Asp  Gly Val Pro Gly Gly  Pro Gly Glu 
    2180                 2185                 2190             


Thr Gly  Lys Asn Gly Gly Phe  Gly Arg Arg Gly Pro  Pro Gly Ala 
    2195                 2200                 2205             


Lys Gly  Asn Lys Gly Gly Pro  Gly Gln Pro Gly Phe  Glu Gly Glu 
    2210                 2215                 2220             


Gln Gly  Thr Arg Gly Ala Gln  Gly Pro Ala Gly Pro  Ala Gly Pro 
    2225                 2230                 2235             


Pro Gly  Leu Ile Gly Glu Gln  Gly Ile Ser Gly Pro  Arg Gly Ser 
    2240                 2245                 2250             


Gly Gly  Ala Ala Gly Ala Pro  Gly Glu Arg Gly Arg  Thr Gly Pro 
    2255                 2260                 2265             


Leu Gly  Arg Lys Gly Glu Pro  Gly Glu Pro Gly Pro  Lys Gly Gly 
    2270                 2275                 2280             


Ile Gly  Asn Arg Gly Pro Arg  Gly Glu Thr Gly Asp  Asp Gly Arg 
    2285                 2290                 2295             


Asp Gly  Val Gly Ser Glu Gly  Arg Arg Gly Lys Lys  Gly Glu Arg 
    2300                 2305                 2310             


Gly Phe  Pro Gly Tyr Pro Gly  Pro Lys Gly Asn Pro  Gly Glu Pro 
    2315                 2320                 2325             


Gly Leu  Asn Gly Thr Thr Gly  Pro Lys Gly Ile Arg  Gly Arg Arg 
    2330                 2335                 2340             


Gly Asn  Ser Gly Pro Pro Gly  Ile Val Gly Gln Lys  Gly Asp Pro 
    2345                 2350                 2355             


Gly Tyr  Pro Gly Pro Ala Gly  Pro Lys Gly Asn Arg  Gly Asp Ser 
    2360                 2365                 2370             


Ile Asp  Gln Cys Ala Leu Ile  Gln Ser Ile Lys Asp  Lys Cys Pro 
    2375                 2380                 2385             


Cys Cys  Tyr Gly Pro Leu Glu  Cys Pro Val Phe Pro  Thr Glu Leu 
    2390                 2395                 2400             


Ala Phe  Ala Leu Asp Thr Ser  Glu Gly Val Asn Gln  Asp Thr Phe 
    2405                 2410                 2415             


Gly Arg  Met Arg Asp Val Val  Leu Ser Ile Val Asn  Asp Leu Thr 
    2420                 2425                 2430             


Ile Ala  Glu Ser Asn Cys Pro  Arg Gly Ala Arg Val  Ala Val Val 
    2435                 2440                 2445             


Thr Tyr  Asn Asn Glu Val Thr  Thr Glu Ile Arg Phe  Ala Asp Ser 
    2450                 2455                 2460             


Lys Arg  Lys Ser Val Leu Leu  Asp Lys Ile Lys Asn  Leu Gln Val 
    2465                 2470                 2475             


Ala Leu  Thr Ser Lys Gln Gln  Ser Leu Glu Thr Ala  Met Ser Phe 
    2480                 2485                 2490             


Val Ala  Arg Asn Thr Phe Lys  Arg Val Arg Asn Gly  Phe Leu Met 
    2495                 2500                 2505             


Arg Lys  Val Ala Val Phe Phe  Ser Asn Thr Pro Thr  Arg Ala Ser 
    2510                 2515                 2520             


Pro Gln  Leu Arg Glu Ala Val  Leu Lys Leu Ser Asp  Ala Gly Ile 
    2525                 2530                 2535             


Thr Pro  Leu Phe Leu Thr Arg  Gln Glu Asp Arg Gln  Leu Ile Asn 
    2540                 2545                 2550             


Ala Leu  Gln Ile Asn Asn Thr  Ala Val Gly His Ala  Leu Val Leu 
    2555                 2560                 2565             


Pro Ala  Gly Arg Asp Leu Thr  Asp Phe Leu Glu Asn  Val Leu Thr 
    2570                 2575                 2580             


Cys His  Val Cys Leu Asp Ile  Cys Asn Ile Asp Pro  Ser Cys Gly 
    2585                 2590                 2595             


Phe Gly  Ser Trp Arg Pro Ser  Phe Arg Asp Arg Arg  Ala Ala Gly 
    2600                 2605                 2610             


Ser Asp  Val Asp Ile Asp Met  Ala Phe Ile Leu Asp  Ser Ala Glu 
    2615                 2620                 2625             


Thr Thr  Thr Leu Phe Gln Phe  Asn Glu Met Lys Lys  Tyr Ile Ala 
    2630                 2635                 2640             


Tyr Leu  Val Arg Gln Leu Asp  Met Ser Pro Asp Pro  Lys Ala Ser 
    2645                 2650                 2655             


Gln His  Phe Ala Arg Val Ala  Val Val Gln His Ala  Pro Ser Glu 
    2660                 2665                 2670             


Ser Val  Asp Asn Ala Ser Met  Pro Pro Val Lys Val  Glu Phe Ser 
    2675                 2680                 2685             


Leu Thr  Asp Tyr Gly Ser Lys  Glu Lys Leu Val Asp  Phe Leu Ser 
    2690                 2695                 2700             


Arg Gly  Met Thr Gln Leu Gln  Gly Thr Arg Ala Leu  Gly Ser Ala 
    2705                 2710                 2715             


Ile Glu  Tyr Thr Ile Glu Asn  Val Phe Glu Ser Ala  Pro Asn Pro 
    2720                 2725                 2730             


Arg Asp  Leu Lys Ile Val Val  Leu Met Leu Thr Gly  Glu Val Pro 
    2735                 2740                 2745             


Glu Gln  Gln Leu Glu Glu Ala  Gln Arg Val Ile Leu  Gln Ala Lys 
    2750                 2755                 2760             


Cys Lys  Gly Tyr Phe Phe Val  Val Leu Gly Ile Gly  Arg Lys Val 
    2765                 2770                 2775             


Asn Ile  Lys Glu Val Tyr Thr  Phe Ala Ser Glu Pro  Asn Asp Val 
    2780                 2785                 2790             


Phe Phe  Lys Leu Val Asp Lys  Ser Thr Glu Leu Asn  Glu Glu Pro 
    2795                 2800                 2805             


Leu Met  Arg Phe Gly Arg Leu  Leu Pro Ser Phe Val  Ser Ser Glu 
    2810                 2815                 2820             


Asn Ala  Phe Tyr Leu Ser Pro  Asp Ile Arg Lys Gln  Cys Asp Trp 
    2825                 2830                 2835             


Phe Gln  Gly Asp Gln Pro Thr  Lys Asn Leu Val Lys  Phe Gly His 
    2840                 2845                 2850             


Lys Gln  Val Asn Val Pro Asn  Asn Val Thr Ser Ser  Pro Thr Ser 
    2855                 2860                 2865             


Asn Pro  Val Thr Thr Thr Lys  Pro Val Thr Thr Thr  Lys Pro Val 
    2870                 2875                 2880             


Thr Thr  Thr Thr Lys Pro Val  Thr Thr Thr Thr Lys  Pro Val Thr 
    2885                 2890                 2895             


Ile Ile  Asn Gln Pro Ser Val  Lys Pro Ala Ala Ala  Lys Pro Ala 
    2900                 2905                 2910             


Pro Ala  Lys Pro Val Ala Ala  Lys Pro Val Ala Thr  Lys Met Ala 
    2915                 2920                 2925             


Thr Val  Arg Pro Pro Val Ala  Val Lys Pro Ala Thr  Ala Ala Lys 
    2930                 2935                 2940             


Pro Val  Ala Ala Lys Pro Ala  Ala Val Arg Pro Pro  Ala Ala Ala 
    2945                 2950                 2955             


Ala Ala  Lys Pro Val Ala Thr  Lys Pro Glu Val Pro  Arg Pro Gln 
    2960                 2965                 2970             


Ala Ala  Lys Pro Ala Ala Thr  Lys Pro Ala Thr Thr  Lys Pro Met 
    2975                 2980                 2985             


Val Lys  Met Ser Arg Glu Val  Gln Val Phe Glu Ile  Thr Glu Asn 
    2990                 2995                 3000             


Ser Ala  Lys Leu His Trp Glu  Arg Ala Glu Pro Pro  Gly Pro Tyr 
    3005                 3010                 3015             


Phe Tyr  Asp Leu Thr Val Thr  Ser Ala His Asp Gln  Ser Leu Val 
    3020                 3025                 3030             


Leu Lys  Gln Asn Leu Thr Val  Thr Asp Arg Val Ile  Gly Gly Leu 
    3035                 3040                 3045             


Leu Ala  Gly Gln Thr Tyr His  Val Ala Val Val Cys  Tyr Leu Arg 
    3050                 3055                 3060             


Ser Gln  Val Arg Ala Thr Tyr  His Gly Ser Phe Ser  Thr Lys Lys 
    3065                 3070                 3075             


Ser Gln  Pro Pro Pro Pro Gln  Pro Ala Arg Ser Ala  Ser Ser Ser 
    3080                 3085                 3090             


Thr Ile  Asn Leu Met Val Ser  Thr Glu Pro Leu Ala  Leu Thr Glu 
    3095                 3100                 3105             


Thr Asp  Ile Cys Lys Leu Pro  Lys Asp Glu Gly Thr  Cys Arg Asp 
    3110                 3115                 3120             


Phe Ile  Leu Lys Trp Tyr Tyr  Asp Pro Asn Thr Lys  Ser Cys Ala 
    3125                 3130                 3135             


Arg Phe  Trp Tyr Gly Gly Cys  Gly Gly Asn Glu Asn  Lys Phe Gly 
    3140                 3145                 3150             


Ser Gln  Lys Glu Cys Glu Lys  Val Cys Ala Pro Val  Leu Ala Lys 
    3155                 3160                 3165             


Pro Gly  Val Ile Ser Val Met  Gly Thr 
    3170                 3175         


<210>  2429
<211>  2614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL6A5__Homo_sapiens__NP_001265227

<400>  2429

Met Lys Ile Leu Leu Ile Ile Phe Val Leu Ile Ile Trp Thr Glu Thr 
1               5                   10                  15      


Leu Ala Asp Gln Ser Pro Gly Pro Gly Pro Val Tyr Ala Asp Val Val 
            20                  25                  30          


Phe Leu Val Asp Ser Ser Asp His Leu Gly Pro Lys Ser Phe Pro Phe 
        35                  40                  45              


Val Lys Thr Phe Ile Asn Lys Met Ile Asn Ser Leu Pro Ile Glu Ala 
    50                  55                  60                  


Asn Lys Tyr Arg Val Ala Leu Ala Gln Tyr Ser Asp Glu Phe His Ser 
65                  70                  75                  80  


Glu Phe His Leu Ser Thr Phe Lys Gly Arg Ser Pro Met Leu Asn His 
                85                  90                  95      


Leu Lys Lys Asn Phe Gln Phe Ile Gly Gly Ser Leu Gln Ile Gly Lys 
            100                 105                 110         


Ala Leu Gln Glu Ala His Arg Thr Tyr Phe Ser Ala Pro Ile Asn Gly 
        115                 120                 125             


Arg Asp Arg Lys Gln Phe Pro Pro Ile Leu Val Val Leu Ala Ser Ala 
    130                 135                 140                 


Glu Ser Glu Asp Glu Val Glu Glu Ala Ser Lys Ala Leu Gln Lys Asp 
145                 150                 155                 160 


Gly Val Lys Ile Ile Ser Val Gly Val Gln Lys Ala Ser Glu Glu Asn 
                165                 170                 175     


Leu Lys Ala Met Ala Thr Ser His Phe His Phe Asn Leu Arg Thr Ile 
            180                 185                 190         


Arg Asp Leu Ser Thr Phe Ser Gln Asn Met Thr Gln Ile Ile Lys Asp 
        195                 200                 205             


Val Thr Lys Tyr Lys Glu Gly Ala Val Asp Ala Asp Met Gln Val His 
    210                 215                 220                 


Phe Pro Ile Ser Cys Gln Lys Asp Ser Leu Ala Asp Leu Val Phe Leu 
225                 230                 235                 240 


Val Asp Glu Ser Leu Gly Thr Gly Gly Asn Leu Arg His Leu Gln Thr 
                245                 250                 255     


Phe Leu Glu Asn Ile Thr Ser Ser Met Asp Val Lys Glu Asn Cys Met 
            260                 265                 270         


Arg Leu Gly Leu Met Ser Tyr Ser Asn Ser Ala Lys Thr Ile Ser Phe 
        275                 280                 285             


Leu Lys Ser Ser Thr Thr Gln Ser Glu Phe Gln Gln Gln Ile Lys Asn 
    290                 295                 300                 


Leu Ser Ile Gln Val Gly Lys Ser Asn Thr Gly Ala Ala Ile Asp Gln 
305                 310                 315                 320 


Met Arg Arg Asp Gly Phe Ser Glu Ser Tyr Gly Ser Arg Arg Ala Gln 
                325                 330                 335     


Gly Val Pro Gln Ile Ala Val Leu Val Thr His Arg Pro Ser Asp Asp 
            340                 345                 350         


Glu Val His Asp Ala Ala Leu Asn Leu Arg Leu Glu Asp Val Asn Val 
        355                 360                 365             


Phe Ala Leu Ser Ile Gln Gly Ala Asn Asn Thr Gln Leu Glu Glu Ile 
    370                 375                 380                 


Val Ser Tyr Pro Pro Glu Gln Thr Ile Ser Thr Leu Lys Ser Tyr Ala 
385                 390                 395                 400 


Asp Leu Glu Thr Tyr Ser Thr Lys Phe Leu Lys Lys Leu Gln Asn Glu 
                405                 410                 415     


Ile Trp Ser Gln Ile Ser Thr Tyr Ala Glu Gln Arg Asn Leu Asp Lys 
            420                 425                 430         


Thr Gly Cys Val Asp Thr Lys Glu Ala Asp Ile His Phe Leu Ile Asp 
        435                 440                 445             


Gly Ser Ser Ser Ile Gln Glu Lys Gln Phe Glu Gln Ile Lys Arg Phe 
    450                 455                 460                 


Met Leu Glu Val Thr Glu Met Phe Ser Ile Gly Pro Asp Lys Val Arg 
465                 470                 475                 480 


Val Gly Val Val Gln Tyr Ser Asp Asp Thr Glu Val Glu Phe Tyr Ile 
                485                 490                 495     


Thr Asp Tyr Ser Asn Asp Ile Asp Leu Arg Lys Ala Ile Phe Asn Ile 
            500                 505                 510         


Lys Gln Leu Thr Gly Gly Thr Tyr Thr Gly Lys Ala Leu Asp Tyr Ile 
        515                 520                 525             


Leu Gln Ile Ile Lys Asn Gly Met Lys Asp Arg Met Ser Lys Val Pro 
    530                 535                 540                 


Cys Tyr Leu Ile Val Leu Thr Asp Gly Met Ser Thr Asp Arg Val Val 
545                 550                 555                 560 


Glu Pro Ala Lys Arg Leu Arg Ala Glu Gln Ile Thr Val His Ala Val 
                565                 570                 575     


Gly Ile Gly Ala Ala Asn Lys Ile Glu Leu Gln Glu Ile Ala Gly Lys 
            580                 585                 590         


Glu Glu Arg Val Ser Phe Gly Gln Asn Phe Asp Ala Leu Lys Ser Ile 
        595                 600                 605             


Lys Asn Glu Val Val Arg Glu Ile Cys Ala Glu Lys Gly Cys Glu Asp 
    610                 615                 620                 


Met Lys Ala Asp Ile Met Phe Leu Val Asp Ser Ser Trp Ser Ile Gly 
625                 630                 635                 640 


Asn Glu Asn Phe Arg Lys Met Lys Ile Phe Met Lys Asn Leu Leu Thr 
                645                 650                 655     


Lys Ile Gln Ile Gly Ala Asp Lys Thr Gln Ile Gly Val Val Gln Phe 
            660                 665                 670         


Ser Asp Lys Thr Lys Glu Glu Phe Gln Leu Asn Arg Tyr Phe Thr Gln 
        675                 680                 685             


Gln Glu Ile Ser Asp Ala Ile Asp Arg Met Ser Leu Ile Asn Glu Gly 
    690                 695                 700                 


Thr Leu Thr Gly Lys Ala Leu Asn Phe Val Gly Gln Tyr Phe Thr His 
705                 710                 715                 720 


Ser Lys Gly Ala Arg Leu Gly Ala Lys Lys Phe Leu Ile Leu Ile Thr 
                725                 730                 735     


Asp Gly Val Ala Gln Asp Asp Val Arg Asp Pro Ala Arg Ile Leu Arg 
            740                 745                 750         


Gly Lys Asp Val Thr Ile Phe Ser Val Gly Val Tyr Asn Ala Asn Arg 
        755                 760                 765             


Ser Gln Leu Glu Glu Ile Ser Gly Asp Ser Ser Leu Val Phe His Val 
    770                 775                 780                 


Glu Asn Phe Asp His Leu Lys Ala Leu Glu Arg Lys Leu Ile Phe Arg 
785                 790                 795                 800 


Val Cys Ala Leu His Asp Cys Lys Arg Ile Thr Leu Leu Asp Val Val 
                805                 810                 815     


Phe Val Leu Asp His Ser Gly Ser Ile Lys Lys Gln Tyr Gln Asp His 
            820                 825                 830         


Met Ile Asn Leu Thr Ile His Leu Val Lys Lys Ala Asp Val Gly Arg 
        835                 840                 845             


Asp Arg Val Gln Phe Gly Ala Leu Lys Tyr Ser Asp Gln Pro Asn Ile 
    850                 855                 860                 


Leu Phe Tyr Leu Asn Thr Tyr Ser Asn Arg Ser Ala Ile Ile Glu Asn 
865                 870                 875                 880 


Leu Arg Lys Arg Arg Asp Thr Gly Gly Asn Thr Tyr Thr Ala Lys Ala 
                885                 890                 895     


Leu Lys His Ala Asn Ala Leu Phe Thr Glu Glu His Gly Ser Arg Ile 
            900                 905                 910         


Lys Gln Asn Val Lys Gln Met Leu Ile Val Ile Thr Asp Gly Glu Ser 
        915                 920                 925             


His Asp His Asp Gln Leu Asn Asp Thr Ala Leu Glu Leu Arg Asn Lys 
    930                 935                 940                 


Gly Ile Thr Ile Phe Ala Val Gly Val Gly Lys Ala Asn Gln Lys Glu 
945                 950                 955                 960 


Leu Glu Gly Met Ala Gly Asn Lys Asn Asn Thr Ile Tyr Val Asp Asn 
                965                 970                 975     


Phe Asp Lys Leu Lys Asp Val Phe Thr Leu Val Gln Glu Arg Met Cys 
            980                 985                 990         


Thr Glu Ala Pro Glu Val Cys His  Leu Gln Glu Ala Asp  Val Ile Phe 
        995                 1000                 1005             


Leu Cys  Asp Gly Ser Asp Arg  Val Ser Asn Ser Asp  Phe Val Thr 
    1010                 1015                 1020             


Met Thr  Thr Phe Leu Ser Asp  Leu Ile Asp Asn Phe  Asp Ile Gln 
    1025                 1030                 1035             


Ser Gln  Arg Met Lys Ile Gly  Met Ala Gln Phe Gly  Ser Asn Tyr 
    1040                 1045                 1050             


Gln Ser  Ile Ile Glu Leu Lys  Asn Ser Leu Thr Lys  Thr Gln Trp 
    1055                 1060                 1065             


Lys Thr  Gln Ile Gln Asn Val  Ser Lys Ser Gly Gly  Phe Pro Arg 
    1070                 1075                 1080             


Ile Asp  Phe Ala Leu Lys Lys  Val Ser Asn Met Phe  Asn Leu His 
    1085                 1090                 1095             


Ala Gly  Gly Arg Arg Asn Ala  Gly Val Pro Gln Thr  Leu Val Val 
    1100                 1105                 1110             


Ile Thr  Ser Gly Asp Pro Arg  Tyr Asp Val Ala Asp  Ala Val Lys 
    1115                 1120                 1125             


Thr Leu  Lys Asp Leu Gly Ile  Cys Val Leu Val Leu  Gly Ile Gly 
    1130                 1135                 1140             


Asp Val  Tyr Lys Glu His Leu  Leu Pro Ile Thr Gly  Asn Ser Glu 
    1145                 1150                 1155             


Lys Ile  Ile Thr Phe Gln Asp  Phe Asp Lys Leu Lys  Asn Val Asp 
    1160                 1165                 1170             


Val Lys  Lys Arg Ile Ile Arg  Glu Ile Cys Gln Ser  Cys Gly Lys 
    1175                 1180                 1185             


Thr Asn  Cys Phe Met Asp Ile  Val Val Gly Phe Asp  Ile Ser Thr 
    1190                 1195                 1200             


His Val  Gln Gly Gln Pro Leu  Phe Gln Gly His Pro  Gln Leu Glu 
    1205                 1210                 1215             


Ser Tyr  Leu Pro Gly Ile Leu  Glu Asp Ile Ser Ser  Ile Lys Gly 
    1220                 1225                 1230             


Val Ser  Cys Gly Ala Gly Thr  Glu Ala Gln Val Ser  Leu Ala Phe 
    1235                 1240                 1245             


Lys Val  Asn Ser Asp Gln Gly  Phe Pro Ala Lys Phe  Gln Ile Tyr 
    1250                 1255                 1260             


Gln Lys  Ala Val Phe Asp Ser  Leu Leu Gln Val Asn  Val Ser Gly 
    1265                 1270                 1275             


Pro Thr  His Leu Asn Ala Gln  Phe Leu Arg Ser Leu  Trp Asp Thr 
    1280                 1285                 1290             


Phe Lys  Asp Lys Ser Ala Ser  Arg Gly Gln Val Leu  Leu Ile Phe 
    1295                 1300                 1305             


Ser Asp  Gly Leu Gln Ser Glu  Ser Asn Ile Met Leu  Glu Asn Gln 
    1310                 1315                 1320             


Ser Asp  Arg Leu Arg Glu Ala  Gly Leu Asp Ala Leu  Leu Val Val 
    1325                 1330                 1335             


Ser Leu  Asn Thr Thr Ala His  His Glu Phe Ser Ser  Phe Glu Phe 
    1340                 1345                 1350             


Gly Lys  Arg Phe Asp Tyr Arg  Thr His Leu Thr Ile  Gly Met Arg 
    1355                 1360                 1365             


Glu Leu  Gly Lys Lys Leu Ser  Gln Tyr Leu Gly Asn  Ile Ala Glu 
    1370                 1375                 1380             


Arg Thr  Cys Cys Cys Thr Phe  Cys Lys Cys Pro Gly  Ile Pro Gly 
    1385                 1390                 1395             


Pro His  Gly Thr Arg Gly Leu  Gln Ala Met Lys Gly  Ser Gln Gly 
    1400                 1405                 1410             


Leu Lys  Gly Ser Arg Gly His  Arg Gly Glu Asp Gly  Asn Pro Gly 
    1415                 1420                 1425             


Val Arg  Gly Asp Thr Gly Pro  Gln Gly Asp Lys Gly  Ile Ala Gly 
    1430                 1435                 1440             


Cys Pro  Gly Ala Trp Gly Gln  Lys Gly Leu Lys Gly  Phe Ser Gly 
    1445                 1450                 1455             


Pro Lys  Gly Gly His Gly Asp  Asp Gly Ile Asp Gly  Leu Asp Gly 
    1460                 1465                 1470             


Glu Glu  Gly Cys His Gly Phe  Pro Gly Ile Lys Gly  Glu Lys Gly 
    1475                 1480                 1485             


Asp Pro  Gly Ser Gln Gly Ser  Pro Gly Ser Arg Gly  Ala Pro Gly 
    1490                 1495                 1500             


Gln Tyr  Gly Glu Lys Gly Phe  Pro Gly Asp Pro Gly  Asn Pro Gly 
    1505                 1510                 1515             


Gln Asn  Asn Asn Ile Lys Gly  Gln Lys Gly Ser Lys  Gly Glu Gln 
    1520                 1525                 1530             


Gly Arg  Gln Gly Arg Ser Gly  Gln Lys Gly Val Gln  Gly Ser Pro 
    1535                 1540                 1545             


Ser Ser  Arg Gly Ser Arg Gly  Arg Glu Gly Gln Arg  Gly Leu Arg 
    1550                 1555                 1560             


Gly Val  Ser Gly Glu Pro Gly  Asn Pro Gly Pro Thr  Gly Thr Leu 
    1565                 1570                 1575             


Gly Ala  Glu Gly Leu Gln Gly  Pro Gln Gly Ser Gln  Gly Asn Pro 
    1580                 1585                 1590             


Gly Arg  Lys Gly Glu Lys Gly  Ser Gln Gly Gln Lys  Gly Pro Gln 
    1595                 1600                 1605             


Gly Ser  Pro Gly Leu Met Gly  Ala Lys Gly Ser Thr  Gly Arg Pro 
    1610                 1615                 1620             


Gly Leu  Leu Gly Lys Lys Gly  Glu Pro Gly Leu Pro  Gly Asp Leu 
    1625                 1630                 1635             


Gly Pro  Val Gly Gln Thr Gly  Gln Arg Gly Arg Gln  Gly Asp Ser 
    1640                 1645                 1650             


Gly Ile  Pro Gly Tyr Gly Gln  Met Gly Arg Lys Gly  Val Lys Gly 
    1655                 1660                 1665             


Pro Arg  Gly Phe Pro Gly Asp  Ala Gly Gln Lys Gly  Asp Ile Gly 
    1670                 1675                 1680             


Asn Pro  Gly Ile Pro Gly Gly  Pro Gly Pro Lys Gly  Phe Arg Gly 
    1685                 1690                 1695             


Leu Ala  Leu Thr Val Gly Leu  Lys Gly Glu Glu Gly  Ser Arg Gly 
    1700                 1705                 1710             


Leu Pro  Gly Pro Pro Gly Gln  Arg Gly Ile Lys Gly  Met Ala Gly 
    1715                 1720                 1725             


Gln Pro  Val Tyr Ser Gln Cys  Asp Leu Ile Arg Phe  Leu Arg Glu 
    1730                 1735                 1740             


His Ser  Pro Cys Trp Lys Glu  Lys Cys Pro Ala Tyr  Pro Thr Glu 
    1745                 1750                 1755             


Leu Val  Phe Ala Leu Asp Asn  Ser Tyr Asp Val Thr  Glu Glu Ser 
    1760                 1765                 1770             


Phe Asn  Lys Thr Arg Asp Ile  Ile Thr Ser Ile Val  Asn Asp Leu 
    1775                 1780                 1785             


Asn Ile  Arg Glu Asn Asn Cys  Pro Val Gly Ala Arg  Val Ala Met 
    1790                 1795                 1800             


Val Ser  Tyr Asn Ser Gly Thr  Ser Tyr Leu Ile Arg  Trp Ser Asp 
    1805                 1810                 1815             


Tyr Asn  Arg Lys Lys Gln Leu  Leu Gln Gln Leu Ser  Gln Ile Lys 
    1820                 1825                 1830             


Tyr Gln  Asp Thr Thr Glu Pro  Arg Asp Val Gly Asn  Ala Met Arg 
    1835                 1840                 1845             


Phe Val  Thr Arg Asn Val Phe  Lys Arg Thr Tyr Ala  Gly Ala Asn 
    1850                 1855                 1860             


Val Arg  Arg Val Ala Val Phe  Phe Ser Asn Gly Gln  Thr Ala Ser 
    1865                 1870                 1875             


Arg Ser  Ser Ile Ile Thr Ala  Thr Met Glu Phe Ser  Ala Leu Asp 
    1880                 1885                 1890             


Ile Ser  Pro Thr Val Phe Ala  Phe Asp Glu Arg Val  Phe Leu Glu 
    1895                 1900                 1905             


Ala Phe  Gly Phe Asp Asn Thr  Gly Thr Phe Gln Val  Ile Pro Val 
    1910                 1915                 1920             


Pro Pro  Asn Gly Glu Asn Gln  Thr Leu Glu Arg Leu  Arg Arg Cys 
    1925                 1930                 1935             


Ala Leu  Cys Tyr Asp Lys Cys  Phe Pro Asn Ala Cys  Ile Arg Glu 
    1940                 1945                 1950             


Ala Phe  Leu Pro Glu Asp Ser  Tyr Met Asp Val Val  Phe Leu Ile 
    1955                 1960                 1965             


Asp Asn  Ser Arg Asn Ile Ala  Lys Asp Glu Phe Lys  Ala Val Lys 
    1970                 1975                 1980             


Ala Leu  Val Ser Ser Val Ile  Asp Asn Phe Asn Ile  Ala Ser Asp 
    1985                 1990                 1995             


Pro Leu  Ile Ser Asp Ser Gly  Asp Arg Ile Ala Leu  Leu Ser Tyr 
    2000                 2005                 2010             


Ser Pro  Trp Glu Ser Ser Arg  Arg Lys Met Gly Thr  Val Lys Thr 
    2015                 2020                 2025             


Glu Phe  Asp Phe Ile Thr Tyr  Asp Asn Gln Leu Leu  Met Lys Asn 
    2030                 2035                 2040             


His Ile  Gln Thr Ser Phe Gln  Gln Leu Asn Gly Glu  Ala Thr Ile 
    2045                 2050                 2055             


Gly Arg  Ala Leu Leu Trp Thr  Thr Glu Asn Leu Phe  Pro Glu Thr 
    2060                 2065                 2070             


Pro Tyr  Leu Arg Lys His Lys  Val Ile Phe Val Val  Ser Ala Gly 
    2075                 2080                 2085             


Glu Asn  Tyr Glu Arg Lys Glu  Phe Val Lys Met Met  Ala Leu Arg 
    2090                 2095                 2100             


Ala Lys  Cys Gln Gly Tyr Val  Ile Phe Val Ile Ser  Leu Gly Ser 
    2105                 2110                 2115             


Thr Arg  Lys Asp Asp Met Glu  Glu Leu Ala Ser Tyr  Pro Leu Asp 
    2120                 2125                 2130             


Gln His  Leu Ile Gln Leu Gly  Arg Ile His Lys Pro  Asp Leu Asn 
    2135                 2140                 2145             


Tyr Ile  Ala Lys Phe Leu Lys  Pro Phe Leu Tyr Ser  Val Arg Arg 
    2150                 2155                 2160             


Gly Phe  Asn Gln Tyr Pro Pro  Pro Met Leu Glu Asp  Ala Cys Arg 
    2165                 2170                 2175             


Leu Ile  Asn Leu Gly Gly Glu  Asn Ile Gln Asn Asp  Gly Phe Gln 
    2180                 2185                 2190             


Phe Val  Thr Glu Leu Gln Glu  Asp Phe Leu Gly Gly  Asn Gly Phe 
    2195                 2200                 2205             


Ile Gly  Gln Glu Leu Asn Ser  Gly Arg Glu Ser Pro  Phe Val Lys 
    2210                 2215                 2220             


Thr Glu  Asp Asn Gly Ser Asp  Tyr Leu Val Tyr Leu  Pro Ser Gln 
    2225                 2230                 2235             


Met Phe  Glu Pro Gln Lys Leu  Met Ile Asn Tyr Glu  Lys Asp Gln 
    2240                 2245                 2250             


Lys Ser  Ala Glu Ile Ala Ser  Leu Thr Ser Gly His  Glu Asn Tyr 
    2255                 2260                 2265             


Gly Arg  Lys Glu Glu Pro Asp  His Thr Tyr Glu Pro  Gly Asp Val 
    2270                 2275                 2280             


Ser Leu  Gln Glu Tyr Tyr Met  Asp Val Ala Phe Leu  Ile Asp Ala 
    2285                 2290                 2295             


Ser Gln  Arg Val Gly Ser Asp  Glu Phe Lys Glu Val  Lys Ala Phe 
    2300                 2305                 2310             


Ile Thr  Ser Val Leu Asp Tyr  Phe His Ile Ala Pro  Thr Pro Leu 
    2315                 2320                 2325             


Thr Ser  Thr Leu Gly Asp Arg  Val Ala Val Leu Ser  Tyr Ser Pro 
    2330                 2335                 2340             


Pro Gly  Tyr Met Pro Asn Thr  Glu Glu Cys Pro Val  Tyr Leu Glu 
    2345                 2350                 2355             


Phe Asp  Leu Val Thr Tyr Asn  Ser Ile His Gln Met  Lys His His 
    2360                 2365                 2370             


Leu Gln  Asp Ser Gln Gln Leu  Asn Gly Asp Val Phe  Ile Gly His 
    2375                 2380                 2385             


Ala Leu  Gln Trp Thr Ile Asp  Asn Val Phe Val Gly  Thr Pro Asn 
    2390                 2395                 2400             


Leu Arg  Lys Asn Lys Val Ile  Phe Val Ile Ser Ala  Gly Glu Thr 
    2405                 2410                 2415             


Asn Ser  Leu Asp Lys Asp Val  Leu Arg Asn Val Ser  Leu Arg Ala 
    2420                 2425                 2430             


Lys Cys  Gln Gly Tyr Ser Ile  Phe Val Phe Ser Phe  Gly Pro Lys 
    2435                 2440                 2445             


His Asn  Asp Lys Glu Leu Glu  Glu Leu Ala Ser His  Pro Leu Asp 
    2450                 2455                 2460             


His His  Leu Val Gln Leu Gly  Arg Thr His Lys Pro  Asp Trp Asn 
    2465                 2470                 2475             


Tyr Ile  Ile Lys Phe Val Lys  Pro Phe Val His Leu  Ile Arg Arg 
    2480                 2485                 2490             


Ala Ile  Asn Lys Tyr Pro Thr  Glu Asp Met Lys Ala  Thr Cys Val 
    2495                 2500                 2505             


Asn Met  Thr Ser Pro Asn Pro  Glu Asn Gly Gly Thr  Glu Asn Thr 
    2510                 2515                 2520             


Val Leu  Leu Leu Pro Gly Ile  Tyr Glu Ile Lys Thr  Glu Asn Gly 
    2525                 2530                 2535             


Asp Leu  Phe Asp Glu Phe Asp  Ser Gln Ala Gln His  Leu Leu Val 
    2540                 2545                 2550             


Leu Gly  Asn Asn His Ser Ser  Gly Ser Glu Thr Ala  Thr Asp Leu 
    2555                 2560                 2565             


Met Gln  Lys Leu Tyr Leu Leu  Phe Ser Thr Glu Lys  Leu Ala Met 
    2570                 2575                 2580             


Lys Asp  Lys Glu Lys Ala His  Leu Glu Glu Ile Ser  Ala Leu Val 
    2585                 2590                 2595             


Val Asp  Lys Gln Gln Glu Lys  Glu Asp Gly Glu Asp  Thr Arg Ser 
    2600                 2605                 2610             


Ser 
    


<210>  2430
<211>  2944
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL7A1__Homo_sapiens__NP_000085

<400>  2430

Met Thr Leu Arg Leu Leu Val Ala Ala Leu Cys Ala Gly Ile Leu Ala 
1               5                   10                  15      


Glu Ala Pro Arg Val Arg Ala Gln His Arg Glu Arg Val Thr Cys Thr 
            20                  25                  30          


Arg Leu Tyr Ala Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ser Ser 
        35                  40                  45              


Ile Gly Arg Ser Asn Phe Arg Glu Val Arg Ser Phe Leu Glu Gly Leu 
    50                  55                  60                  


Val Leu Pro Phe Ser Gly Ala Ala Ser Ala Gln Gly Val Arg Phe Ala 
65                  70                  75                  80  


Thr Val Gln Tyr Ser Asp Asp Pro Arg Thr Glu Phe Gly Leu Asp Ala 
                85                  90                  95      


Leu Gly Ser Gly Gly Asp Val Ile Arg Ala Ile Arg Glu Leu Ser Tyr 
            100                 105                 110         


Lys Gly Gly Asn Thr Arg Thr Gly Ala Ala Ile Leu His Val Ala Asp 
        115                 120                 125             


His Val Phe Leu Pro Gln Leu Ala Arg Pro Gly Val Pro Lys Val Cys 
    130                 135                 140                 


Ile Leu Ile Thr Asp Gly Lys Ser Gln Asp Leu Val Asp Thr Ala Ala 
145                 150                 155                 160 


Gln Arg Leu Lys Gly Gln Gly Val Lys Leu Phe Ala Val Gly Ile Lys 
                165                 170                 175     


Asn Ala Asp Pro Glu Glu Leu Lys Arg Val Ala Ser Gln Pro Thr Ser 
            180                 185                 190         


Asp Phe Phe Phe Phe Val Asn Asp Phe Ser Ile Leu Arg Thr Leu Leu 
        195                 200                 205             


Pro Leu Val Ser Arg Arg Val Cys Thr Thr Ala Gly Gly Val Pro Val 
    210                 215                 220                 


Thr Arg Pro Pro Asp Asp Ser Thr Ser Ala Pro Arg Asp Leu Val Leu 
225                 230                 235                 240 


Ser Glu Pro Ser Ser Gln Ser Leu Arg Val Gln Trp Thr Ala Ala Ser 
                245                 250                 255     


Gly Pro Val Thr Gly Tyr Lys Val Gln Tyr Thr Pro Leu Thr Gly Leu 
            260                 265                 270         


Gly Gln Pro Leu Pro Ser Glu Arg Gln Glu Val Asn Val Pro Ala Gly 
        275                 280                 285             


Glu Thr Ser Val Arg Leu Arg Gly Leu Arg Pro Leu Thr Glu Tyr Gln 
    290                 295                 300                 


Val Thr Val Ile Ala Leu Tyr Ala Asn Ser Ile Gly Glu Ala Val Ser 
305                 310                 315                 320 


Gly Thr Ala Arg Thr Thr Ala Leu Glu Gly Pro Glu Leu Thr Ile Gln 
                325                 330                 335     


Asn Thr Thr Ala His Ser Leu Leu Val Ala Trp Arg Ser Val Pro Gly 
            340                 345                 350         


Ala Thr Gly Tyr Arg Val Thr Trp Arg Val Leu Ser Gly Gly Pro Thr 
        355                 360                 365             


Gln Gln Gln Glu Leu Gly Pro Gly Gln Gly Ser Val Leu Leu Arg Asp 
    370                 375                 380                 


Leu Glu Pro Gly Thr Asp Tyr Glu Val Thr Val Ser Thr Leu Phe Gly 
385                 390                 395                 400 


Arg Ser Val Gly Pro Ala Thr Ser Leu Met Ala Arg Thr Asp Ala Ser 
                405                 410                 415     


Val Glu Gln Thr Leu Arg Pro Val Ile Leu Gly Pro Thr Ser Ile Leu 
            420                 425                 430         


Leu Ser Trp Asn Leu Val Pro Glu Ala Arg Gly Tyr Arg Leu Glu Trp 
        435                 440                 445             


Arg Arg Glu Thr Gly Leu Glu Pro Pro Gln Lys Val Val Leu Pro Ser 
    450                 455                 460                 


Asp Val Thr Arg Tyr Gln Leu Asp Gly Leu Gln Pro Gly Thr Glu Tyr 
465                 470                 475                 480 


Arg Leu Thr Leu Tyr Thr Leu Leu Glu Gly His Glu Val Ala Thr Pro 
                485                 490                 495     


Ala Thr Val Val Pro Thr Gly Pro Glu Leu Pro Val Ser Pro Val Thr 
            500                 505                 510         


Asp Leu Gln Ala Thr Glu Leu Pro Gly Gln Arg Val Arg Val Ser Trp 
        515                 520                 525             


Ser Pro Val Pro Gly Ala Thr Gln Tyr Arg Ile Ile Val Arg Ser Thr 
    530                 535                 540                 


Gln Gly Val Glu Arg Thr Leu Val Leu Pro Gly Ser Gln Thr Ala Phe 
545                 550                 555                 560 


Asp Leu Asp Asp Val Gln Ala Gly Leu Ser Tyr Thr Val Arg Val Ser 
                565                 570                 575     


Ala Arg Val Gly Pro Arg Glu Gly Ser Ala Ser Val Leu Thr Val Arg 
            580                 585                 590         


Arg Glu Pro Glu Thr Pro Leu Ala Val Pro Gly Leu Arg Val Val Val 
        595                 600                 605             


Ser Asp Ala Thr Arg Val Arg Val Ala Trp Gly Pro Val Pro Gly Ala 
    610                 615                 620                 


Ser Gly Phe Arg Ile Ser Trp Ser Thr Gly Ser Gly Pro Glu Ser Ser 
625                 630                 635                 640 


Gln Thr Leu Pro Pro Asp Ser Thr Ala Thr Asp Ile Thr Gly Leu Gln 
                645                 650                 655     


Pro Gly Thr Thr Tyr Gln Val Ala Val Ser Val Leu Arg Gly Arg Glu 
            660                 665                 670         


Glu Gly Pro Ala Ala Val Ile Val Ala Arg Thr Asp Pro Leu Gly Pro 
        675                 680                 685             


Val Arg Thr Val His Val Thr Gln Ala Ser Ser Ser Ser Val Thr Ile 
    690                 695                 700                 


Thr Trp Thr Arg Val Pro Gly Ala Thr Gly Tyr Arg Val Ser Trp His 
705                 710                 715                 720 


Ser Ala His Gly Pro Glu Lys Ser Gln Leu Val Ser Gly Glu Ala Thr 
                725                 730                 735     


Val Ala Glu Leu Asp Gly Leu Glu Pro Asp Thr Glu Tyr Thr Val His 
            740                 745                 750         


Val Arg Ala His Val Ala Gly Val Asp Gly Pro Pro Ala Ser Val Val 
        755                 760                 765             


Val Arg Thr Ala Pro Glu Pro Val Gly Arg Val Ser Arg Leu Gln Ile 
    770                 775                 780                 


Leu Asn Ala Ser Ser Asp Val Leu Arg Ile Thr Trp Val Gly Val Thr 
785                 790                 795                 800 


Gly Ala Thr Ala Tyr Arg Leu Ala Trp Gly Arg Ser Glu Gly Gly Pro 
                805                 810                 815     


Met Arg His Gln Ile Leu Pro Gly Asn Thr Asp Ser Ala Glu Ile Arg 
            820                 825                 830         


Gly Leu Glu Gly Gly Val Ser Tyr Ser Val Arg Val Thr Ala Leu Val 
        835                 840                 845             


Gly Asp Arg Glu Gly Thr Pro Val Ser Ile Val Val Thr Thr Pro Pro 
    850                 855                 860                 


Glu Ala Pro Pro Ala Leu Gly Thr Leu His Val Val Gln Arg Gly Glu 
865                 870                 875                 880 


His Ser Leu Arg Leu Arg Trp Glu Pro Val Pro Arg Ala Gln Gly Phe 
                885                 890                 895     


Leu Leu His Trp Gln Pro Glu Gly Gly Gln Glu Gln Ser Arg Val Leu 
            900                 905                 910         


Gly Pro Glu Leu Ser Ser Tyr His Leu Asp Gly Leu Glu Pro Ala Thr 
        915                 920                 925             


Gln Tyr Arg Val Arg Leu Ser Val Leu Gly Pro Ala Gly Glu Gly Pro 
    930                 935                 940                 


Ser Ala Glu Val Thr Ala Arg Thr Glu Ser Pro Arg Val Pro Ser Ile 
945                 950                 955                 960 


Glu Leu Arg Val Val Asp Thr Ser Ile Asp Ser Val Thr Leu Ala Trp 
                965                 970                 975     


Thr Pro Val Ser Arg Ala Ser Ser Tyr Ile Leu Ser Trp Arg Pro Leu 
            980                 985                 990         


Arg Gly Pro Gly Gln Glu Val Pro  Gly Ser Pro Gln Thr  Leu Pro Gly 
        995                 1000                 1005             


Ile Ser  Ser Ser Gln Arg Val  Thr Gly Leu Glu Pro  Gly Val Ser 
    1010                 1015                 1020             


Tyr Ile  Phe Ser Leu Thr Pro  Val Leu Asp Gly Val  Arg Gly Pro 
    1025                 1030                 1035             


Glu Ala  Ser Val Thr Gln Thr  Pro Val Cys Pro Arg  Gly Leu Ala 
    1040                 1045                 1050             


Asp Val  Val Phe Leu Pro His  Ala Thr Gln Asp Asn  Ala His Arg 
    1055                 1060                 1065             


Ala Glu  Ala Thr Arg Arg Val  Leu Glu Arg Leu Val  Leu Ala Leu 
    1070                 1075                 1080             


Gly Pro  Leu Gly Pro Gln Ala  Val Gln Val Gly Leu  Leu Ser Tyr 
    1085                 1090                 1095             


Ser His  Arg Pro Ser Pro Leu  Phe Pro Leu Asn Gly  Ser His Asp 
    1100                 1105                 1110             


Leu Gly  Ile Ile Leu Gln Arg  Ile Arg Asp Met Pro  Tyr Met Asp 
    1115                 1120                 1125             


Pro Ser  Gly Asn Asn Leu Gly  Thr Ala Val Val Thr  Ala His Arg 
    1130                 1135                 1140             


Tyr Met  Leu Ala Pro Asp Ala  Pro Gly Arg Arg Gln  His Val Pro 
    1145                 1150                 1155             


Gly Val  Met Val Leu Leu Val  Asp Glu Pro Leu Arg  Gly Asp Ile 
    1160                 1165                 1170             


Phe Ser  Pro Ile Arg Glu Ala  Gln Ala Ser Gly Leu  Asn Val Val 
    1175                 1180                 1185             


Met Leu  Gly Met Ala Gly Ala  Asp Pro Glu Gln Leu  Arg Arg Leu 
    1190                 1195                 1200             


Ala Pro  Gly Met Asp Ser Val  Gln Thr Phe Phe Ala  Val Asp Asp 
    1205                 1210                 1215             


Gly Pro  Ser Leu Asp Gln Ala  Val Ser Gly Leu Ala  Thr Ala Leu 
    1220                 1225                 1230             


Cys Gln  Ala Ser Phe Thr Thr  Gln Pro Arg Pro Glu  Pro Cys Pro 
    1235                 1240                 1245             


Val Tyr  Cys Pro Lys Gly Gln  Lys Gly Glu Pro Gly  Glu Met Gly 
    1250                 1255                 1260             


Leu Arg  Gly Gln Val Gly Pro  Pro Gly Asp Pro Gly  Leu Pro Gly 
    1265                 1270                 1275             


Arg Thr  Gly Ala Pro Gly Pro  Gln Gly Pro Pro Gly  Ser Ala Thr 
    1280                 1285                 1290             


Ala Lys  Gly Glu Arg Gly Phe  Pro Gly Ala Asp Gly  Arg Pro Gly 
    1295                 1300                 1305             


Ser Pro  Gly Arg Ala Gly Asn  Pro Gly Thr Pro Gly  Ala Pro Gly 
    1310                 1315                 1320             


Leu Lys  Gly Ser Pro Gly Leu  Pro Gly Pro Arg Gly  Asp Pro Gly 
    1325                 1330                 1335             


Glu Arg  Gly Pro Arg Gly Pro  Lys Gly Glu Pro Gly  Ala Pro Gly 
    1340                 1345                 1350             


Gln Val  Ile Gly Gly Glu Gly  Pro Gly Leu Pro Gly  Arg Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Pro Ser Gly Pro  Pro Gly Pro Arg Gly  Pro Leu Gly 
    1370                 1375                 1380             


Asp Pro  Gly Pro Arg Gly Pro  Pro Gly Leu Pro Gly  Thr Ala Met 
    1385                 1390                 1395             


Lys Gly  Asp Lys Gly Asp Arg  Gly Glu Arg Gly Pro  Pro Gly Pro 
    1400                 1405                 1410             


Gly Glu  Gly Gly Ile Ala Pro  Gly Glu Pro Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Ser Pro Gly Pro Gln  Gly Pro Val Gly Pro  Pro Gly Lys 
    1430                 1435                 1440             


Lys Gly  Glu Lys Gly Asp Ser  Glu Asp Gly Ala Pro  Gly Leu Pro 
    1445                 1450                 1455             


Gly Gln  Pro Gly Ser Pro Gly  Glu Gln Gly Pro Arg  Gly Pro Pro 
    1460                 1465                 1470             


Gly Ala  Ile Gly Pro Lys Gly  Asp Arg Gly Phe Pro  Gly Pro Leu 
    1475                 1480                 1485             


Gly Glu  Ala Gly Glu Lys Gly  Glu Arg Gly Pro Pro  Gly Pro Ala 
    1490                 1495                 1500             


Gly Ser  Arg Gly Leu Pro Gly  Val Ala Gly Arg Pro  Gly Ala Lys 
    1505                 1510                 1515             


Gly Pro  Glu Gly Pro Pro Gly  Pro Thr Gly Arg Gln  Gly Glu Lys 
    1520                 1525                 1530             


Gly Glu  Pro Gly Arg Pro Gly  Asp Pro Ala Val Val  Gly Pro Ala 
    1535                 1540                 1545             


Val Ala  Gly Pro Lys Gly Glu  Lys Gly Asp Val Gly  Pro Ala Gly 
    1550                 1555                 1560             


Pro Arg  Gly Ala Thr Gly Val  Gln Gly Glu Arg Gly  Pro Pro Gly 
    1565                 1570                 1575             


Leu Val  Leu Pro Gly Asp Pro  Gly Pro Lys Gly Asp  Pro Gly Asp 
    1580                 1585                 1590             


Arg Gly  Pro Ile Gly Leu Thr  Gly Arg Ala Gly Pro  Pro Gly Asp 
    1595                 1600                 1605             


Ser Gly  Pro Pro Gly Glu Lys  Gly Asp Pro Gly Arg  Pro Gly Pro 
    1610                 1615                 1620             


Pro Gly  Pro Val Gly Pro Arg  Gly Arg Asp Gly Glu  Val Gly Glu 
    1625                 1630                 1635             


Lys Gly  Asp Glu Gly Pro Pro  Gly Asp Pro Gly Leu  Pro Gly Lys 
    1640                 1645                 1650             


Ala Gly  Glu Arg Gly Leu Arg  Gly Ala Pro Gly Val  Arg Gly Pro 
    1655                 1660                 1665             


Val Gly  Glu Lys Gly Asp Gln  Gly Asp Pro Gly Glu  Asp Gly Arg 
    1670                 1675                 1680             


Asn Gly  Ser Pro Gly Ser Ser  Gly Pro Lys Gly Asp  Arg Gly Glu 
    1685                 1690                 1695             


Pro Gly  Pro Pro Gly Pro Pro  Gly Arg Leu Val Asp  Thr Gly Pro 
    1700                 1705                 1710             


Gly Ala  Arg Glu Lys Gly Glu  Pro Gly Asp Arg Gly  Gln Glu Gly 
    1715                 1720                 1725             


Pro Arg  Gly Pro Lys Gly Asp  Pro Gly Leu Pro Gly  Ala Pro Gly 
    1730                 1735                 1740             


Glu Arg  Gly Ile Glu Gly Phe  Arg Gly Pro Pro Gly  Pro Gln Gly 
    1745                 1750                 1755             


Asp Pro  Gly Val Arg Gly Pro  Ala Gly Glu Lys Gly  Asp Arg Gly 
    1760                 1765                 1770             


Pro Pro  Gly Leu Asp Gly Arg  Ser Gly Leu Asp Gly  Lys Pro Gly 
    1775                 1780                 1785             


Ala Ala  Gly Pro Ser Gly Pro  Asn Gly Ala Ala Gly  Lys Ala Gly 
    1790                 1795                 1800             


Asp Pro  Gly Arg Asp Gly Leu  Pro Gly Leu Arg Gly  Glu Gln Gly 
    1805                 1810                 1815             


Leu Pro  Gly Pro Ser Gly Pro  Pro Gly Leu Pro Gly  Lys Pro Gly 
    1820                 1825                 1830             


Glu Asp  Gly Lys Pro Gly Leu  Asn Gly Lys Asn Gly  Glu Pro Gly 
    1835                 1840                 1845             


Asp Pro  Gly Glu Asp Gly Arg  Lys Gly Glu Lys Gly  Asp Ser Gly 
    1850                 1855                 1860             


Ala Ser  Gly Arg Glu Gly Arg  Asp Gly Pro Lys Gly  Glu Arg Gly 
    1865                 1870                 1875             


Ala Pro  Gly Ile Leu Gly Pro  Gln Gly Pro Pro Gly  Leu Pro Gly 
    1880                 1885                 1890             


Pro Val  Gly Pro Pro Gly Gln  Gly Phe Pro Gly Val  Pro Gly Gly 
    1895                 1900                 1905             


Thr Gly  Pro Lys Gly Asp Arg  Gly Glu Thr Gly Ser  Lys Gly Glu 
    1910                 1915                 1920             


Gln Gly  Leu Pro Gly Glu Arg  Gly Leu Arg Gly Glu  Pro Gly Ser 
    1925                 1930                 1935             


Val Pro  Asn Val Asp Arg Leu  Leu Glu Thr Ala Gly  Ile Lys Ala 
    1940                 1945                 1950             


Ser Ala  Leu Arg Glu Ile Val  Glu Thr Trp Asp Glu  Ser Ser Gly 
    1955                 1960                 1965             


Ser Phe  Leu Pro Val Pro Glu  Arg Arg Arg Gly Pro  Lys Gly Asp 
    1970                 1975                 1980             


Ser Gly  Glu Gln Gly Pro Pro  Gly Lys Glu Gly Pro  Ile Gly Phe 
    1985                 1990                 1995             


Pro Gly  Glu Arg Gly Leu Lys  Gly Asp Arg Gly Asp  Pro Gly Pro 
    2000                 2005                 2010             


Gln Gly  Pro Pro Gly Leu Ala  Leu Gly Glu Arg Gly  Pro Pro Gly 
    2015                 2020                 2025             


Pro Ser  Gly Leu Ala Gly Glu  Pro Gly Lys Pro Gly  Ile Pro Gly 
    2030                 2035                 2040             


Leu Pro  Gly Arg Ala Gly Gly  Val Gly Glu Ala Gly  Arg Pro Gly 
    2045                 2050                 2055             


Glu Arg  Gly Glu Arg Gly Glu  Lys Gly Glu Arg Gly  Glu Gln Gly 
    2060                 2065                 2070             


Arg Asp  Gly Pro Pro Gly Leu  Pro Gly Thr Pro Gly  Pro Pro Gly 
    2075                 2080                 2085             


Pro Pro  Gly Pro Lys Val Ser  Val Asp Glu Pro Gly  Pro Gly Leu 
    2090                 2095                 2100             


Ser Gly  Glu Gln Gly Pro Pro  Gly Leu Lys Gly Ala  Lys Gly Glu 
    2105                 2110                 2115             


Pro Gly  Ser Asn Gly Asp Gln  Gly Pro Lys Gly Asp  Arg Gly Val 
    2120                 2125                 2130             


Pro Gly  Ile Lys Gly Asp Arg  Gly Glu Pro Gly Pro  Arg Gly Gln 
    2135                 2140                 2145             


Asp Gly  Asn Pro Gly Leu Pro  Gly Glu Arg Gly Met  Ala Gly Pro 
    2150                 2155                 2160             


Glu Gly  Lys Pro Gly Leu Gln  Gly Pro Arg Gly Pro  Pro Gly Pro 
    2165                 2170                 2175             


Val Gly  Gly His Gly Asp Pro  Gly Pro Pro Gly Ala  Pro Gly Leu 
    2180                 2185                 2190             


Ala Gly  Pro Ala Gly Pro Gln  Gly Pro Ser Gly Leu  Lys Gly Glu 
    2195                 2200                 2205             


Pro Gly  Glu Thr Gly Pro Pro  Gly Arg Gly Leu Thr  Gly Pro Thr 
    2210                 2215                 2220             


Gly Ala  Val Gly Leu Pro Gly  Pro Pro Gly Pro Ser  Gly Leu Val 
    2225                 2230                 2235             


Gly Pro  Gln Gly Ser Pro Gly  Leu Pro Gly Gln Val  Gly Glu Thr 
    2240                 2245                 2250             


Gly Lys  Pro Gly Ala Pro Gly  Arg Asp Gly Ala Ser  Gly Lys Asp 
    2255                 2260                 2265             


Gly Asp  Arg Gly Ser Pro Gly  Val Pro Gly Ser Pro  Gly Leu Pro 
    2270                 2275                 2280             


Gly Pro  Val Gly Pro Lys Gly  Glu Pro Gly Pro Thr  Gly Ala Pro 
    2285                 2290                 2295             


Gly Gln  Ala Val Val Gly Leu  Pro Gly Ala Lys Gly  Glu Lys Gly 
    2300                 2305                 2310             


Ala Pro  Gly Gly Leu Ala Gly  Asp Leu Val Gly Glu  Pro Gly Ala 
    2315                 2320                 2325             


Lys Gly  Asp Arg Gly Leu Pro  Gly Pro Arg Gly Glu  Lys Gly Glu 
    2330                 2335                 2340             


Ala Gly  Arg Ala Gly Glu Pro  Gly Asp Pro Gly Glu  Asp Gly Gln 
    2345                 2350                 2355             


Lys Gly  Ala Pro Gly Pro Lys  Gly Phe Lys Gly Asp  Pro Gly Val 
    2360                 2365                 2370             


Gly Val  Pro Gly Ser Pro Gly  Pro Pro Gly Pro Pro  Gly Val Lys 
    2375                 2380                 2385             


Gly Asp  Leu Gly Leu Pro Gly  Leu Pro Gly Ala Pro  Gly Val Val 
    2390                 2395                 2400             


Gly Phe  Pro Gly Gln Thr Gly  Pro Arg Gly Glu Met  Gly Gln Pro 
    2405                 2410                 2415             


Gly Pro  Ser Gly Glu Arg Gly  Leu Ala Gly Pro Pro  Gly Arg Glu 
    2420                 2425                 2430             


Gly Ile  Pro Gly Pro Leu Gly  Pro Pro Gly Pro Pro  Gly Ser Val 
    2435                 2440                 2445             


Gly Pro  Pro Gly Ala Ser Gly  Leu Lys Gly Asp Lys  Gly Asp Pro 
    2450                 2455                 2460             


Gly Val  Gly Leu Pro Gly Pro  Arg Gly Glu Arg Gly  Glu Pro Gly 
    2465                 2470                 2475             


Ile Arg  Gly Glu Asp Gly Arg  Pro Gly Gln Glu Gly  Pro Arg Gly 
    2480                 2485                 2490             


Leu Thr  Gly Pro Pro Gly Ser  Arg Gly Glu Arg Gly  Glu Lys Gly 
    2495                 2500                 2505             


Asp Val  Gly Ser Ala Gly Leu  Lys Gly Asp Lys Gly  Asp Ser Ala 
    2510                 2515                 2520             


Val Ile  Leu Gly Pro Pro Gly  Pro Arg Gly Ala Lys  Gly Asp Met 
    2525                 2530                 2535             


Gly Glu  Arg Gly Pro Arg Gly  Leu Asp Gly Asp Lys  Gly Pro Arg 
    2540                 2545                 2550             


Gly Asp  Asn Gly Asp Pro Gly  Asp Lys Gly Ser Lys  Gly Glu Pro 
    2555                 2560                 2565             


Gly Asp  Lys Gly Ser Ala Gly  Leu Pro Gly Leu Arg  Gly Leu Leu 
    2570                 2575                 2580             


Gly Pro  Gln Gly Gln Pro Gly  Ala Ala Gly Ile Pro  Gly Asp Pro 
    2585                 2590                 2595             


Gly Ser  Pro Gly Lys Asp Gly  Val Pro Gly Ile Arg  Gly Glu Lys 
    2600                 2605                 2610             


Gly Asp  Val Gly Phe Met Gly  Pro Arg Gly Leu Lys  Gly Glu Arg 
    2615                 2620                 2625             


Gly Val  Lys Gly Ala Cys Gly  Leu Asp Gly Glu Lys  Gly Asp Lys 
    2630                 2635                 2640             


Gly Glu  Ala Gly Pro Pro Gly  Arg Pro Gly Leu Ala  Gly His Lys 
    2645                 2650                 2655             


Gly Glu  Met Gly Glu Pro Gly  Val Pro Gly Gln Ser  Gly Ala Pro 
    2660                 2665                 2670             


Gly Lys  Glu Gly Leu Ile Gly  Pro Lys Gly Asp Arg  Gly Phe Asp 
    2675                 2680                 2685             


Gly Gln  Pro Gly Pro Lys Gly  Asp Gln Gly Glu Lys  Gly Glu Arg 
    2690                 2695                 2700             


Gly Thr  Pro Gly Ile Gly Gly  Phe Pro Gly Pro Ser  Gly Asn Asp 
    2705                 2710                 2715             


Gly Ser  Ala Gly Pro Pro Gly  Pro Pro Gly Ser Val  Gly Pro Arg 
    2720                 2725                 2730             


Gly Pro  Glu Gly Leu Gln Gly  Gln Lys Gly Glu Arg  Gly Pro Pro 
    2735                 2740                 2745             


Gly Glu  Arg Val Val Gly Ala  Pro Gly Val Pro Gly  Ala Pro Gly 
    2750                 2755                 2760             


Glu Arg  Gly Glu Gln Gly Arg  Pro Gly Pro Ala Gly  Pro Arg Gly 
    2765                 2770                 2775             


Glu Lys  Gly Glu Ala Ala Leu  Thr Glu Asp Asp Ile  Arg Gly Phe 
    2780                 2785                 2790             


Val Arg  Gln Glu Met Ser Gln  His Cys Ala Cys Gln  Gly Gln Phe 
    2795                 2800                 2805             


Ile Ala  Ser Gly Ser Arg Pro  Leu Pro Ser Tyr Ala  Ala Asp Thr 
    2810                 2815                 2820             


Ala Gly  Ser Gln Leu His Ala  Val Pro Val Leu Arg  Val Ser His 
    2825                 2830                 2835             


Ala Glu  Glu Glu Glu Arg Val  Pro Pro Glu Asp Asp  Glu Tyr Ser 
    2840                 2845                 2850             


Glu Tyr  Ser Glu Tyr Ser Val  Glu Glu Tyr Gln Asp  Pro Glu Ala 
    2855                 2860                 2865             


Pro Trp  Asp Ser Asp Asp Pro  Cys Ser Leu Pro Leu  Asp Glu Gly 
    2870                 2875                 2880             


Ser Cys  Thr Ala Tyr Thr Leu  Arg Trp Tyr His Arg  Ala Val Thr 
    2885                 2890                 2895             


Gly Ser  Thr Glu Ala Cys His  Pro Phe Val Tyr Gly  Gly Cys Gly 
    2900                 2905                 2910             


Gly Asn  Ala Asn Arg Phe Gly  Thr Arg Glu Ala Cys  Glu Arg Arg 
    2915                 2920                 2925             


Cys Pro  Pro Arg Val Val Gln  Ser Gln Gly Thr Gly  Thr Ala Gln 
    2930                 2935                 2940             


Asp 
    


<210>  2431
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL8A1__Homo_sapiens__NP_065084

<400>  2431

Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly 
            20                  25                  30          


Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile 
        35                  40                  45              


Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala 
    50                  55                  60                  


Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly 
65                  70                  75                  80  


Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala 
                85                  90                  95      


Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro 
            100                 105                 110         


Leu Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro 
        115                 120                 125             


Arg Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly 
    130                 135                 140                 


Ile Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro 
145                 150                 155                 160 


Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
                165                 170                 175     


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile 
            180                 185                 190         


Pro Gly Pro Gln Gly Pro Pro Gly Pro His Gly Leu Pro Gly Ile Gly 
        195                 200                 205             


Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp 
    210                 215                 220                 


Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys 
225                 230                 235                 240 


Gly Asp Lys Gly Phe Gly Met Pro Gly Ala Pro Gly Val Lys Gly Pro 
                245                 250                 255     


Pro Gly Met His Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Val Gly 
            260                 265                 270         


Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys 
        275                 280                 285             


Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro 
    290                 295                 300                 


Gly Val Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln 
305                 310                 315                 320 


Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln 
                325                 330                 335     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys 
            340                 345                 350         


Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly Met Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly 
    370                 375                 380                 


Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro 
385                 390                 395                 400 


Met Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly 
                405                 410                 415     


Gly Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly 
            420                 425                 430         


Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro 
        435                 440                 445             


Pro Gly Met Arg Gly Leu Pro Gly Pro Ile Gly Pro Lys Gly Glu Ala 
    450                 455                 460                 


Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro 
                485                 490                 495     


Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro 
            500                 505                 510         


Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly 
        515                 520                 525             


Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro 
    530                 535                 540                 


Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro 
                565                 570                 575     


Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro Asp Met Gly Leu Gly Ile 
            580                 585                 590         


Asp Gly Val Lys Pro Pro His Ala Tyr Gly Ala Lys Lys Gly Lys Asn 
        595                 600                 605             


Gly Gly Pro Ala Tyr Glu Met Pro Ala Phe Thr Ala Glu Leu Thr Ala 
    610                 615                 620                 


Pro Phe Pro Pro Val Gly Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr 
625                 630                 635                 640 


Asn Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly Ile Phe Thr Cys Glu 
                645                 650                 655     


Val Pro Gly Val Tyr Tyr Phe Ala Tyr His Val His Cys Lys Gly Gly 
            660                 665                 670         


Asn Val Trp Val Ala Leu Phe Lys Asn Asn Glu Pro Val Met Tyr Thr 
        675                 680                 685             


Tyr Asp Glu Tyr Lys Lys Gly Phe Leu Asp Gln Ala Ser Gly Ser Ala 
    690                 695                 700                 


Val Leu Leu Leu Arg Pro Gly Asp Arg Val Phe Leu Gln Met Pro Ser 
705                 710                 715                 720 


Glu Gln Ala Ala Gly Leu Tyr Ala Gly Gln Tyr Val His Ser Ser Phe 
                725                 730                 735     


Ser Gly Tyr Leu Leu Tyr Pro Met 
            740                 


<210>  2432
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL8A2__Homo_sapiens__NP_001281276

<400>  2432

Met Pro Leu Pro Leu Leu Pro Met Asp Leu Lys Gly Glu Pro Gly Pro 
1               5                   10                  15      


Pro Gly Lys Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Phe Pro 
            20                  25                  30          


Gly Lys Pro Gly Met Gly Lys Pro Gly Leu His Gly Gln Pro Gly Pro 
        35                  40                  45              


Ala Gly Pro Pro Gly Phe Ser Arg Met Gly Lys Ala Gly Pro Pro Gly 
    50                  55                  60                  


Leu Pro Gly Lys Val Gly Pro Pro Gly Gln Pro Gly Leu Arg Gly Glu 
65                  70                  75                  80  


Pro Gly Ile Arg Gly Asp Gln Gly Leu Arg Gly Pro Pro Gly Pro Pro 
                85                  90                  95      


Gly Leu Pro Gly Pro Ser Gly Ile Thr Ile Pro Gly Lys Pro Gly Ala 
            100                 105                 110         


Gln Gly Val Pro Gly Pro Pro Gly Phe Gln Gly Glu Pro Gly Pro Gln 
        115                 120                 125             


Gly Glu Pro Gly Pro Pro Gly Asp Arg Gly Leu Lys Gly Asp Asn Gly 
    130                 135                 140                 


Val Gly Gln Pro Gly Leu Pro Gly Ala Pro Gly Gln Gly Gly Ala Pro 
145                 150                 155                 160 


Gly Pro Pro Gly Leu Pro Gly Pro Ala Gly Leu Gly Lys Pro Gly Leu 
                165                 170                 175     


Asp Gly Leu Pro Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro Pro 
            180                 185                 190         


Gly Val Pro Gly Pro Arg Gly Glu Pro Gly Ala Val Gly Pro Lys Gly 
        195                 200                 205             


Pro Pro Gly Val Asp Gly Val Gly Val Pro Gly Ala Ala Gly Leu Pro 
    210                 215                 220                 


Gly Pro Gln Gly Pro Ser Gly Ala Lys Gly Glu Pro Gly Thr Arg Gly 
225                 230                 235                 240 


Pro Pro Gly Leu Ile Gly Pro Thr Gly Tyr Gly Met Pro Gly Leu Pro 
                245                 250                 255     


Gly Pro Lys Gly Asp Arg Gly Pro Ala Gly Val Pro Gly Leu Leu Gly 
            260                 265                 270         


Asp Arg Gly Glu Pro Gly Glu Asp Gly Glu Pro Gly Glu Gln Gly Pro 
        275                 280                 285             


Gln Gly Leu Gly Gly Pro Pro Gly Leu Pro Gly Ser Ala Gly Leu Pro 
    290                 295                 300                 


Gly Arg Arg Gly Pro Pro Gly Pro Lys Gly Glu Ala Gly Pro Gly Gly 
305                 310                 315                 320 


Pro Pro Gly Val Pro Gly Ile Arg Gly Asp Gln Gly Pro Ser Gly Leu 
                325                 330                 335     


Ala Gly Lys Pro Gly Val Pro Gly Glu Arg Gly Leu Pro Gly Ala His 
            340                 345                 350         


Gly Pro Pro Gly Pro Thr Gly Pro Lys Gly Glu Pro Gly Phe Thr Gly 
        355                 360                 365             


Arg Pro Gly Gly Pro Gly Val Ala Gly Ala Leu Gly Gln Lys Gly Asp 
    370                 375                 380                 


Leu Gly Leu Pro Gly Gln Pro Gly Leu Arg Gly Pro Ser Gly Ile Pro 
385                 390                 395                 400 


Gly Leu Gln Gly Pro Ala Gly Pro Ile Gly Pro Gln Gly Leu Pro Gly 
                405                 410                 415     


Leu Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Glu Gly Arg Ala 
            420                 425                 430         


Gly Glu Pro Gly Thr Ala Gly Pro Thr Gly Pro Pro Gly Val Pro Gly 
        435                 440                 445             


Ser Pro Gly Ile Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
    450                 455                 460                 


Pro Gly Ala Pro Gly Ala Phe Asp Glu Thr Gly Ile Ala Gly Leu His 
465                 470                 475                 480 


Leu Pro Asn Gly Gly Val Glu Gly Ala Val Leu Gly Lys Gly Gly Lys 
                485                 490                 495     


Pro Gln Phe Gly Leu Gly Glu Leu Ser Ala His Ala Thr Pro Ala Phe 
            500                 505                 510         


Thr Ala Val Leu Thr Ser Pro Phe Pro Ala Ser Gly Met Pro Val Lys 
        515                 520                 525             


Phe Asp Arg Thr Leu Tyr Asn Gly His Ser Gly Tyr Asn Pro Ala Thr 
    530                 535                 540                 


Gly Ile Phe Thr Cys Pro Val Gly Gly Val Tyr Tyr Phe Ala Tyr His 
545                 550                 555                 560 


Val His Val Lys Gly Thr Asn Val Trp Val Ala Leu Tyr Lys Asn Asn 
                565                 570                 575     


Val Pro Ala Thr Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Tyr Leu Asp 
            580                 585                 590         


Gln Ala Ser Gly Gly Ala Val Leu Gln Leu Arg Pro Asn Asp Gln Val 
        595                 600                 605             


Trp Val Gln Met Pro Ser Asp Gln Ala Asn Gly Leu Tyr Ser Thr Glu 
    610                 615                 620                 


Tyr Ile His Ser Ser Phe Ser Gly Phe Leu Leu Cys Pro Thr 
625                 630                 635             


<210>  2433
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL9A1__Homo_sapiens__NP_001842

<400>  2433

Met Lys Thr Cys Trp Lys Ile Pro Val Phe Phe Phe Val Cys Ser Phe 
1               5                   10                  15      


Leu Glu Pro Trp Ala Ser Ala Ala Val Lys Arg Arg Pro Arg Phe Pro 
            20                  25                  30          


Val Asn Ser Asn Ser Asn Gly Gly Asn Glu Leu Cys Pro Lys Ile Arg 
        35                  40                  45              


Ile Gly Gln Asp Asp Leu Pro Gly Phe Asp Leu Ile Ser Gln Phe Gln 
    50                  55                  60                  


Val Asp Lys Ala Ala Ser Arg Arg Ala Ile Gln Arg Val Val Gly Ser 
65                  70                  75                  80  


Ala Thr Leu Gln Val Ala Tyr Lys Leu Gly Asn Asn Val Asp Phe Arg 
                85                  90                  95      


Ile Pro Thr Arg Asn Leu Tyr Pro Ser Gly Leu Pro Glu Glu Tyr Ser 
            100                 105                 110         


Phe Leu Thr Thr Phe Arg Met Thr Gly Ser Thr Leu Lys Lys Asn Trp 
        115                 120                 125             


Asn Ile Trp Gln Ile Gln Asp Ser Ser Gly Lys Glu Gln Val Gly Ile 
    130                 135                 140                 


Lys Ile Asn Gly Gln Thr Gln Ser Val Val Phe Ser Tyr Lys Gly Leu 
145                 150                 155                 160 


Asp Gly Ser Leu Gln Thr Ala Ala Phe Ser Asn Leu Ser Ser Leu Phe 
                165                 170                 175     


Asp Ser Gln Trp His Lys Ile Met Ile Gly Val Glu Arg Ser Ser Ala 
            180                 185                 190         


Thr Leu Phe Val Asp Cys Asn Arg Ile Glu Ser Leu Pro Ile Lys Pro 
        195                 200                 205             


Arg Gly Pro Ile Asp Ile Asp Gly Phe Ala Val Leu Gly Lys Leu Ala 
    210                 215                 220                 


Asp Asn Pro Gln Val Ser Val Pro Phe Glu Leu Gln Trp Met Leu Ile 
225                 230                 235                 240 


His Cys Asp Pro Leu Arg Pro Arg Arg Glu Thr Cys His Glu Leu Pro 
                245                 250                 255     


Ala Arg Ile Thr Pro Ser Gln Thr Thr Asp Glu Arg Gly Pro Pro Gly 
            260                 265                 270         


Glu Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ile 
        275                 280                 285             


Asp Gly Ile Asp Gly Asp Arg Gly Pro Lys Gly Pro Pro Gly Pro Pro 
    290                 295                 300                 


Gly Pro Ala Gly Glu Pro Gly Lys Pro Gly Ala Pro Gly Lys Pro Gly 
305                 310                 315                 320 


Thr Pro Gly Ala Asp Gly Leu Thr Gly Pro Asp Gly Ser Pro Gly Ser 
                325                 330                 335     


Ile Gly Ser Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Ser Arg 
            340                 345                 350         


Gly Phe Pro Gly Arg Gly Ile Pro Gly Pro Pro Gly Pro Pro Gly Thr 
        355                 360                 365             


Ala Gly Leu Pro Gly Glu Leu Gly Arg Val Gly Pro Val Gly Asp Pro 
    370                 375                 380                 


Gly Arg Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
385                 390                 395                 400 


Thr Ile Gly Phe His Asp Gly Asp Pro Leu Cys Pro Asn Ala Cys Pro 
                405                 410                 415     


Pro Gly Arg Ser Gly Tyr Pro Gly Leu Pro Gly Met Arg Gly His Lys 
            420                 425                 430         


Gly Ala Lys Gly Glu Ile Gly Glu Pro Gly Arg Gln Gly His Lys Gly 
        435                 440                 445             


Glu Glu Gly Asp Gln Gly Glu Leu Gly Glu Val Gly Ala Gln Gly Pro 
    450                 455                 460                 


Pro Gly Ala Gln Gly Leu Arg Gly Ile Thr Gly Ile Val Gly Asp Lys 
465                 470                 475                 480 


Gly Glu Lys Gly Ala Arg Gly Leu Asp Gly Glu Pro Gly Pro Gln Gly 
                485                 490                 495     


Leu Pro Gly Ala Pro Gly Asp Gln Gly Gln Arg Gly Pro Pro Gly Glu 
            500                 505                 510         


Ala Gly Pro Lys Gly Asp Arg Gly Ala Glu Gly Ala Arg Gly Ile Pro 
        515                 520                 525             


Gly Leu Pro Gly Pro Lys Gly Asp Thr Gly Leu Pro Gly Val Asp Gly 
    530                 535                 540                 


Arg Asp Gly Ile Pro Gly Met Pro Gly Thr Lys Gly Glu Pro Gly Lys 
545                 550                 555                 560 


Pro Gly Pro Pro Gly Asp Ala Gly Leu Gln Gly Leu Pro Gly Val Pro 
                565                 570                 575     


Gly Ile Pro Gly Ala Lys Gly Val Ala Gly Glu Lys Gly Ser Thr Gly 
            580                 585                 590         


Ala Pro Gly Lys Pro Gly Gln Met Gly Asn Ser Gly Lys Pro Gly Gln 
        595                 600                 605             


Gln Gly Pro Pro Gly Glu Val Gly Pro Arg Gly Pro Gln Gly Leu Pro 
    610                 615                 620                 


Gly Ser Arg Gly Glu Leu Gly Pro Val Gly Ser Pro Gly Leu Pro Gly 
625                 630                 635                 640 


Lys Leu Gly Ser Leu Gly Ser Pro Gly Leu Pro Gly Leu Pro Gly Pro 
                645                 650                 655     


Pro Gly Leu Pro Gly Met Lys Gly Asp Arg Gly Val Val Gly Glu Pro 
            660                 665                 670         


Gly Pro Lys Gly Glu Gln Gly Ala Ser Gly Glu Glu Gly Glu Ala Gly 
        675                 680                 685             


Glu Arg Gly Glu Leu Gly Asp Ile Gly Leu Pro Gly Pro Lys Gly Ser 
    690                 695                 700                 


Ala Gly Asn Pro Gly Glu Pro Gly Leu Arg Gly Pro Glu Gly Ser Arg 
705                 710                 715                 720 


Gly Leu Pro Gly Val Glu Gly Pro Arg Gly Pro Pro Gly Pro Arg Gly 
                725                 730                 735     


Val Gln Gly Glu Gln Gly Ala Thr Gly Leu Pro Gly Val Gln Gly Pro 
            740                 745                 750         


Pro Gly Arg Ala Pro Thr Asp Gln His Ile Lys Gln Val Cys Met Arg 
        755                 760                 765             


Val Ile Gln Glu His Phe Ala Glu Met Ala Ala Ser Leu Lys Arg Pro 
    770                 775                 780                 


Asp Ser Gly Ala Thr Gly Leu Pro Gly Arg Pro Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Pro Gly Pro Pro Gly Glu Asn Gly Phe Pro Gly Gln Met Gly Ile Arg 
                805                 810                 815     


Gly Leu Pro Gly Ile Lys Gly Pro Pro Gly Ala Leu Gly Leu Arg Gly 
            820                 825                 830         


Pro Lys Gly Asp Leu Gly Glu Lys Gly Glu Arg Gly Pro Pro Gly Arg 
        835                 840                 845             


Gly Pro Asn Gly Leu Pro Gly Ala Ile Gly Leu Pro Gly Asp Pro Gly 
    850                 855                 860                 


Pro Ala Ser Tyr Gly Arg Asn Gly Arg Asp Gly Glu Arg Gly Pro Pro 
865                 870                 875                 880 


Gly Val Ala Gly Ile Pro Gly Val Pro Gly Pro Pro Gly Pro Pro Gly 
                885                 890                 895     


Leu Pro Gly Phe Cys Glu Pro Ala Ser Cys Thr Met Gln Ala Gly Gln 
            900                 905                 910         


Arg Ala Phe Asn Lys Gly Pro Asp Pro 
        915                 920     


<210>  2434
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL9A2__Homo_sapiens__XP_011539020

<400>  2434

Met Ala Ala Ala Thr Ala Ser Pro Arg Ser Leu Leu Val Leu Leu Gln 
1               5                   10                  15      


Val Val Val Leu Ala Leu Ala Gln Ile Arg Gly Pro Pro Gly Glu Arg 
            20                  25                  30          


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Ser Asp Gly 
        35                  40                  45              


Ile Asp Gly Asp Asn Gly Pro Pro Gly Lys Ala Gly Pro Pro Gly Pro 
    50                  55                  60                  


Lys Gly Glu Pro Gly Lys Ala Gly Pro Asp Gly Pro Asp Gly Lys Pro 
65                  70                  75                  80  


Gly Ile Asp Gly Leu Thr Gly Ala Lys Gly Glu Pro Gly Pro Met Gly 
                85                  90                  95      


Ile Pro Gly Val Lys Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Leu 
            100                 105                 110         


Pro Gly Pro Gly Phe Ala Gly Pro Pro Gly Pro Pro Gly Pro Val Gly 
        115                 120                 125             


Leu Pro Gly Glu Ile Gly Ile Arg Gly Pro Lys Gly Asp Pro Gly Pro 
    130                 135                 140                 


Asp Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Arg Pro 
145                 150                 155                 160 


Gly Thr Ile Gln Gly Leu Glu Gly Ser Ala Asp Phe Leu Val Arg Asp 
                165                 170                 175     


Glu Cys Pro Thr Asn Cys Pro Pro Gly Met Lys Gly Pro Pro Gly Leu 
            180                 185                 190         


Gln Gly Val Lys Gly His Ala Gly Lys Arg Gly Ile Leu Gly Asp Pro 
        195                 200                 205             


Gly His Gln Gly Lys Pro Gly Pro Lys Gly Asp Val Gly Ala Ser Gly 
    210                 215                 220                 


Glu Gln Gly Ile Pro Gly Pro Pro Gly Pro Gln Gly Ile Arg Gly Tyr 
225                 230                 235                 240 


Pro Gly Met Ala Gly Pro Lys Gly Glu Thr Gly Pro His Gly Tyr Lys 
                245                 250                 255     


Gly Met Val Gly Ala Ile Gly Ala Thr Gly Pro Pro Gly Glu Glu Gly 
            260                 265                 270         


Pro Arg Gly Pro Pro Gly Arg Ala Gly Glu Lys Gly Asp Glu Gly Ser 
        275                 280                 285             


Pro Gly Ile Arg Gly Pro Gln Gly Ile Thr Gly Pro Lys Gly Ala Thr 
    290                 295                 300                 


Gly Pro Pro Gly Ile Asn Gly Lys Asp Gly Thr Pro Gly Thr Pro Gly 
305                 310                 315                 320 


Met Lys Gly Ser Ala Gly Gln Ala Gly Gln Pro Gly Ser Pro Gly His 
                325                 330                 335     


Gln Gly Leu Ala Thr Pro Gly Pro Gly Arg Gln Ala Ile Leu Cys Ala 
            340                 345                 350         


Pro Leu Leu Cys His His Cys Gly Asn Val Gln Leu Ser Ser Ser Cys 
        355                 360                 365             


Arg Gly Trp Thr Phe Cys Cys Ser Ala Pro Thr Gly Gly Gly Asn Leu 
    370                 375                 380                 


Asp Trp Gly Trp Glu Ala Lys Gln Gln Val His Gly Ala Pro Ser Cys 
385                 390                 395                 400 


Gln Gly Arg Asn 
                


<210>  2435
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COL9A3__Homo_sapiens__NP_001844

<400>  2435

Met Ala Gly Pro Arg Ala Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Leu Leu Ala Ala Ala Gly Ala Gln Arg Val Gly Leu Pro Gly 
            20                  25                  30          


Pro Pro Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Gln Asp Gly Ile 
        35                  40                  45              


Asp Gly Glu Ala Gly Pro Pro Gly Leu Pro Gly Pro Pro Gly Pro Lys 
    50                  55                  60                  


Gly Ala Pro Gly Lys Pro Gly Lys Pro Gly Glu Ala Gly Leu Pro Gly 
65                  70                  75                  80  


Leu Pro Gly Val Asp Gly Leu Thr Gly Arg Asp Gly Pro Pro Gly Pro 
                85                  90                  95      


Lys Gly Ala Pro Gly Glu Arg Gly Ser Leu Gly Pro Pro Gly Pro Pro 
            100                 105                 110         


Gly Leu Gly Gly Lys Gly Leu Pro Gly Pro Pro Gly Glu Ala Gly Val 
        115                 120                 125             


Ser Gly Pro Pro Gly Gly Ile Gly Leu Arg Gly Pro Pro Gly Pro Ser 
    130                 135                 140                 


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
145                 150                 155                 160 


His Pro Gly Val Leu Pro Glu Gly Ala Thr Asp Leu Gln Cys Pro Ser 
                165                 170                 175     


Ile Cys Pro Pro Gly Pro Pro Gly Pro Pro Gly Met Pro Gly Phe Lys 
            180                 185                 190         


Gly Pro Thr Gly Tyr Lys Gly Glu Gln Gly Glu Val Gly Lys Asp Gly 
        195                 200                 205             


Glu Lys Gly Asp Pro Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ser 
    210                 215                 220                 


Val Gly Leu Gln Gly Pro Arg Gly Leu Arg Gly Leu Pro Gly Pro Leu 
225                 230                 235                 240 


Gly Pro Pro Gly Asp Arg Gly Pro Ile Gly Phe Arg Gly Pro Pro Gly 
                245                 250                 255     


Ile Pro Gly Ala Pro Gly Lys Ala Gly Asp Arg Gly Glu Arg Gly Pro 
            260                 265                 270         


Glu Gly Phe Arg Gly Pro Lys Gly Asp Leu Gly Arg Pro Gly Pro Lys 
        275                 280                 285             


Gly Thr Pro Gly Val Ala Gly Pro Ser Gly Glu Pro Gly Met Pro Gly 
    290                 295                 300                 


Lys Asp Gly Gln Asn Gly Val Pro Gly Leu Asp Gly Gln Lys Gly Glu 
305                 310                 315                 320 


Ala Gly Arg Asn Gly Ala Pro Gly Glu Lys Gly Pro Asn Gly Leu Pro 
                325                 330                 335     


Gly Leu Pro Gly Arg Ala Gly Ser Lys Gly Glu Lys Gly Glu Arg Gly 
            340                 345                 350         


Arg Ala Gly Glu Leu Gly Glu Ala Gly Pro Ser Gly Glu Pro Gly Val 
        355                 360                 365             


Pro Gly Asp Ala Gly Met Pro Gly Glu Arg Gly Glu Ala Gly His Arg 
    370                 375                 380                 


Gly Ser Ala Gly Ala Leu Gly Pro Gln Gly Pro Pro Gly Ala Pro Gly 
385                 390                 395                 400 


Val Arg Gly Phe Gln Gly Gln Lys Gly Ser Met Gly Asp Pro Gly Leu 
                405                 410                 415     


Pro Gly Pro Gln Gly Leu Arg Gly Asp Val Gly Asp Arg Gly Pro Gly 
            420                 425                 430         


Gly Ala Ala Gly Pro Lys Gly Asp Gln Gly Ile Ala Gly Ser Asp Gly 
        435                 440                 445             


Leu Pro Gly Asp Lys Gly Glu Leu Gly Pro Ser Gly Leu Val Gly Pro 
    450                 455                 460                 


Lys Gly Glu Ser Gly Ser Arg Gly Glu Leu Gly Pro Lys Gly Thr Gln 
465                 470                 475                 480 


Gly Pro Asn Gly Thr Ser Gly Val Gln Gly Val Pro Gly Pro Pro Gly 
                485                 490                 495     


Pro Leu Gly Leu Gln Gly Val Pro Gly Val Pro Gly Ile Thr Gly Lys 
            500                 505                 510         


Pro Gly Val Pro Gly Lys Glu Ala Ser Glu Gln Arg Ile Arg Glu Leu 
        515                 520                 525             


Cys Gly Gly Met Ile Ser Glu Gln Ile Ala Gln Leu Ala Ala His Leu 
    530                 535                 540                 


Arg Lys Pro Leu Ala Pro Gly Ser Ile Gly Arg Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Ser Ile Gly His Pro Gly Ala 
                565                 570                 575     


Arg Gly Pro Pro Gly Tyr Arg Gly Pro Thr Gly Glu Leu Gly Asp Pro 
            580                 585                 590         


Gly Pro Arg Gly Asn Gln Gly Asp Arg Gly Asp Lys Gly Ala Ala Gly 
        595                 600                 605             


Ala Gly Leu Asp Gly Pro Glu Gly Asp Gln Gly Pro Gln Gly Pro Gln 
    610                 615                 620                 


Gly Val Pro Gly Thr Ser Lys Asp Gly Gln Asp Gly Ala Pro Gly Glu 
625                 630                 635                 640 


Pro Gly Pro Pro Gly Asp Pro Gly Leu Pro Gly Ala Ile Gly Ala Gln 
                645                 650                 655     


Gly Thr Pro Gly Ile Cys Asp Thr Ser Ala Cys Gln Gly Ala Val Leu 
            660                 665                 670         


Gly Gly Val Gly Glu Lys Ser Gly Ser Arg Ser Ser 
        675                 680                 


<210>  2436
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COLCA1__Homo_sapiens__NP_001289574

<400>  2436

Met Glu Ser Cys Ser Val Ala Gln Ala Gly Val Leu Thr Ser Pro Phe 
1               5                   10                  15      


Met Trp Arg Trp Thr Gly Met Ala Gly Ala Leu Ser Ala Leu Asp Asn 
            20                  25                  30          


Thr Ile Glu Asp Asp Ala Asp Asp Gln Leu Pro Cys Gly Glu Gly Arg 
        35                  40                  45              


Pro Gly Trp Val Arg Gly Glu Leu Leu Gly Ser Gln Gly Val Cys Lys 
    50                  55                  60                  


Asp Ser Lys Asp Leu Phe Val Pro Thr Ser Ser Ser Leu Tyr Gly Cys 
65                  70                  75                  80  


Phe Cys Val Gly Leu Val Ser Gly Met Ala Ile Ser Val Leu Leu Leu 
                85                  90                  95      


Ala Ser Asp Phe Arg Lys Leu Asp Phe Ser Arg Pro Glu Pro Cys Phe 
            100                 105                 110         


Glu Lys Glu Ala Ser Leu Trp Phe Val Ala Gln His 
        115                 120                 


<210>  2437
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COLCA2__Homo_sapiens__NP_001258386

<400>  2437

Met His Pro Glu Pro Leu Leu Asn Ser Thr Gln Ser Ala Pro His His 
1               5                   10                  15      


Phe Pro Asp Ser Phe Gln Ala Thr Pro Phe Cys Phe Asn Gln Ser Leu 
            20                  25                  30          


Ile Pro Gly Ser Pro Ser Asn Ser Ser Ile Leu Ser Gly Ser Leu Asp 
        35                  40                  45              


Tyr Ser Tyr Ser Pro Val Gln Leu Pro Ser Tyr Ala Pro Glu Asn Tyr 
    50                  55                  60                  


Asn Ser Pro Ala Ser Leu Asp Thr Arg Thr Cys Gly Tyr Pro Pro Glu 
65                  70                  75                  80  


Asp His Ser Tyr Gln His Leu Ser Ser His Ala Gln Tyr Ser Cys Phe 
                85                  90                  95      


Ser Ser Ala Thr Thr Ser Ile Cys Tyr Cys Ala Ser Cys Glu Ala Glu 
            100                 105                 110         


Asp Leu Asp Ala Leu Gln Ala Ala Glu Tyr Phe Tyr Pro Ser Thr Asp 
        115                 120                 125             


Cys Val Asp Phe Ala Pro Ser Ala Ala Ala Thr Ser Asp Phe Tyr Lys 
    130                 135                 140                 


Arg Glu Thr Asn Cys Asp Ile Cys Tyr Ser 
145                 150                 


<210>  2438
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COLEC10__Homo_sapiens__NP_006429

<400>  2438

Met Asn Gly Phe Ala Ser Leu Leu Arg Arg Asn Gln Phe Ile Leu Leu 
1               5                   10                  15      


Val Leu Phe Leu Leu Gln Ile Gln Ser Leu Gly Leu Asp Ile Asp Ser 
            20                  25                  30          


Arg Pro Thr Ala Glu Val Cys Ala Thr His Thr Ile Ser Pro Gly Pro 
        35                  40                  45              


Lys Gly Asp Asp Gly Glu Lys Gly Asp Pro Gly Glu Glu Gly Lys His 
    50                  55                  60                  


Gly Lys Val Gly Arg Met Gly Pro Lys Gly Ile Lys Gly Glu Leu Gly 
65                  70                  75                  80  


Asp Met Gly Asp Gln Gly Asn Ile Gly Lys Thr Gly Pro Ile Gly Lys 
                85                  90                  95      


Lys Gly Asp Lys Gly Glu Lys Gly Leu Leu Gly Ile Pro Gly Glu Lys 
            100                 105                 110         


Gly Lys Ala Gly Thr Val Cys Asp Cys Gly Arg Tyr Arg Lys Phe Val 
        115                 120                 125             


Gly Gln Leu Asp Ile Ser Ile Ala Arg Leu Lys Thr Ser Met Lys Phe 
    130                 135                 140                 


Val Lys Asn Val Ile Ala Gly Ile Arg Glu Thr Glu Glu Lys Phe Tyr 
145                 150                 155                 160 


Tyr Ile Val Gln Glu Glu Lys Asn Tyr Arg Glu Ser Leu Thr His Cys 
                165                 170                 175     


Arg Ile Arg Gly Gly Met Leu Ala Met Pro Lys Asp Glu Ala Ala Asn 
            180                 185                 190         


Thr Leu Ile Ala Asp Tyr Val Ala Lys Ser Gly Phe Phe Arg Val Phe 
        195                 200                 205             


Ile Gly Val Asn Asp Leu Glu Arg Glu Gly Gln Tyr Met Phe Thr Asp 
    210                 215                 220                 


Asn Thr Pro Leu Gln Asn Tyr Ser Asn Trp Asn Glu Gly Glu Pro Ser 
225                 230                 235                 240 


Asp Pro Tyr Gly His Glu Asp Cys Val Glu Met Leu Ser Ser Gly Arg 
                245                 250                 255     


Trp Asn Asp Thr Glu Cys His Leu Thr Met Tyr Phe Val Cys Glu Phe 
            260                 265                 270         


Ile Lys Lys Lys Lys 
        275         


<210>  2439
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COLEC11__Homo_sapiens__NP_001242912

<400>  2439

Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu 
        35                  40                  45              


Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr 
    50                  55                  60                  


Gly Glu Lys Gly Glu Lys Gly Asp Ser Gly Asp Ile Gly Pro Pro Gly 
65                  70                  75                  80  


Pro Asn Gly Glu Pro Gly Leu Pro Cys Glu Cys Ser Gln Leu Arg Lys 
                85                  90                  95      


Ala Ile Gly Glu Met Asp Asn Gln Val Ser Gln Leu Thr Ser Glu Leu 
            100                 105                 110         


Lys Phe Ile Lys Asn Ala Val Ala Gly Val Arg Glu Thr Glu Ser Lys 
        115                 120                 125             


Ile Tyr Leu Leu Val Lys Glu Glu Lys Arg Tyr Ala Asp Ala Gln Leu 
    130                 135                 140                 


Ser Cys Gln Gly Arg Gly Gly Thr Leu Ser Met Pro Lys Asp Glu Ala 
145                 150                 155                 160 


Ala Asn Gly Leu Met Ala Ala Tyr Leu Ala Gln Ala Gly Leu Ala Arg 
                165                 170                 175     


Val Phe Ile Gly Ile Asn Asp Leu Glu Lys Glu Gly Ala Phe Val Tyr 
            180                 185                 190         


Ser Asp His Ser Pro Met Arg Thr Phe Asn Lys Trp Arg Ser Gly Glu 
        195                 200                 205             


Pro Asn Asn Ala Tyr Asp Glu Glu Asp Cys Val Glu Met Val Ala Ser 
    210                 215                 220                 


Gly Gly Trp Asn Asp Val Ala Cys His Thr Thr Met Tyr Phe Met Cys 
225                 230                 235                 240 


Glu Phe Asp Lys Glu Asn Met 
                245         


<210>  2440
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COLEC12__Homo_sapiens__NP_569057

<400>  2440

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  2441
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COLGALT2__Homo_sapiens__NP_001290349

<400>  2441

Met Ala Ala Arg Pro Ala Ala Thr Leu Ala Trp Ser Leu Leu Leu Leu 
1               5                   10                  15      


Ser Ser Ala Leu Leu Arg Glu Gly Cys Arg Ala Arg Phe Val Ala Glu 
            20                  25                  30          


Arg Asp Ser Glu Asp Asp Gly Glu Glu Pro Val Val Phe Pro Glu Ser 
        35                  40                  45              


Pro Leu Gln Ser Pro Thr Val Leu Val Ala Val Leu Ala Arg Asn Ala 
    50                  55                  60                  


Ala His Thr Leu Pro His Phe Leu Gly Cys Leu Glu Arg Leu Asp Tyr 
65                  70                  75                  80  


Pro Lys Ser Arg Met Ala Ile Trp Ala Ala Thr Asp His Asn Val Asp 
                85                  90                  95      


Asn Thr Thr Glu Ile Phe Arg Glu Trp Leu Lys Asn Val Gln Arg Leu 
            100                 105                 110         


Tyr His Tyr Val Glu Trp Arg Pro Met Asp Glu Pro Glu Ser Tyr Pro 
        115                 120                 125             


Asp Glu Ile Gly Pro Lys His Trp Pro Thr Ser Arg Phe Ala His Val 
    130                 135                 140                 


Met Lys Leu Arg Gln Ala Ala Leu Arg Thr Ala Arg Glu Lys Trp Ser 
145                 150                 155                 160 


Asp Tyr Ile Leu Phe Ile Asp Val Asp Asn Phe Leu Thr Asn Pro Gln 
                165                 170                 175     


Thr Leu Asn Leu Leu Ile Ala Glu Asn Lys Thr Ile Val Ala Pro Met 
            180                 185                 190         


Leu Glu Ser Arg Gly Leu Tyr Ser Asn Phe Trp Cys Gly Ile Thr Pro 
        195                 200                 205             


Lys Gly Phe Tyr Lys Arg Thr Pro Asp Tyr Val Gln Ile Arg Glu Trp 
    210                 215                 220                 


Lys Arg Thr Gly Cys Phe Pro Val Pro Met Val His Ser Thr Phe Leu 
225                 230                 235                 240 


Ile Asp Leu Arg Lys Glu Ala Ser Asp Lys Leu Thr Phe Tyr Pro Pro 
                245                 250                 255     


His Gln Asp Tyr Thr Trp Thr Phe Asp Asp Ile Ile Val Phe Ala Phe 
            260                 265                 270         


Ser Ser Arg Gln Ala Gly Ile Gln Met Tyr Leu Cys Asn Arg Glu His 
        275                 280                 285             


Tyr Gly Tyr Leu Pro Ile Pro Leu Lys Pro His Gln Thr Leu Gln Glu 
    290                 295                 300                 


Asp Ile Glu Asn Leu Ile His Val Gln Ile Glu Ala Met Ile Asp Arg 
305                 310                 315                 320 


Pro Pro Met Glu Pro Ser Gln Tyr Val Ser Val Val Pro Lys Tyr Pro 
                325                 330                 335     


Asp Lys Met Gly Phe Asp Glu Ile Phe Met Ile Asn Leu Lys Arg Arg 
            340                 345                 350         


Lys Asp Arg Arg Asp Arg Met Leu Arg Thr Leu Tyr Glu Gln Glu Ile 
        355                 360                 365             


Glu Val Lys Ile Val Glu Ala Val Asp Gly Lys Ala Leu Asn Thr Ser 
    370                 375                 380                 


Gln Leu Lys Ala Leu Asn Ile Glu Met Leu Pro Gly Tyr Arg Asp Pro 
385                 390                 395                 400 


Tyr Ser Ser Arg Pro Leu Thr Arg Gly Glu Ile Gly Cys Phe Leu Ser 
                405                 410                 415     


His Tyr Ser Val Trp Lys Glu Val Ile Asp Arg Glu Leu Glu Lys Thr 
            420                 425                 430         


Leu Val Ile Glu Asp Asp Val Arg Phe Glu His Gln Phe Lys Lys Lys 
        435                 440                 445             


Leu Met Lys Leu Met Asp Asn Ile Asp Gln Ala Gln Leu Asp Trp Glu 
    450                 455                 460                 


Leu Ile Tyr Ile Gly Arg Lys Arg Met Gln Val Lys Glu Pro Glu Lys 
465                 470                 475                 480 


Ala Val Pro Asn Val Ala Asn Leu Val Glu Ala Asp Tyr Ser Tyr Trp 
                485                 490                 495     


Thr Leu Gly Tyr Val Ile Ser Leu Glu Gly Ala Gln Lys Leu Val Gly 
            500                 505                 510         


Ala Asn Pro Phe Gly Lys Met Leu Pro Val Asp Glu Phe Leu Pro Val 
        515                 520                 525             


Met Tyr Asn Lys His Pro Val Leu Leu Ser Ser Pro His Cys His Leu 
    530                 535                 540                 


Phe Gln Thr Leu Ser Asp Asp Cys Gln Arg 
545                 550                 


<210>  2442
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COLQ__Homo_sapiens__NP_005668

<400>  2442

Met Val Val Leu Asn Pro Met Thr Leu Gly Ile Tyr Leu Gln Leu Phe 
1               5                   10                  15      


Phe Leu Ser Ile Val Ser Gln Pro Thr Phe Ile Asn Ser Val Leu Pro 
            20                  25                  30          


Ile Ser Ala Ala Leu Pro Ser Leu Asp Gln Lys Lys Arg Gly Gly His 
        35                  40                  45              


Lys Ala Cys Cys Leu Leu Thr Pro Pro Pro Pro Pro Leu Phe Pro Pro 
    50                  55                  60                  


Pro Phe Phe Arg Gly Gly Arg Ser Pro Leu Leu Ser Pro Asp Met Lys 
65                  70                  75                  80  


Asn Leu Met Leu Glu Leu Glu Thr Ser Gln Ser Pro Cys Met Gln Gly 
                85                  90                  95      


Ser Leu Gly Ser Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Leu 
            100                 105                 110         


Pro Gly Lys Thr Gly Pro Lys Gly Glu Lys Gly Glu Leu Gly Arg Pro 
        115                 120                 125             


Gly Arg Lys Gly Arg Pro Gly Pro Pro Gly Val Pro Gly Met Pro Gly 
    130                 135                 140                 


Pro Ile Gly Trp Pro Gly Pro Glu Gly Pro Arg Gly Glu Lys Gly Asp 
145                 150                 155                 160 


Leu Gly Met Met Gly Leu Pro Gly Ser Arg Gly Pro Met Gly Ser Lys 
                165                 170                 175     


Gly Tyr Pro Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Glu Lys Gly 
            180                 185                 190         


Asp Leu Gly Pro Lys Gly Glu Lys Gly Phe Pro Gly Phe Pro Gly Met 
        195                 200                 205             


Leu Gly Gln Lys Gly Glu Met Gly Pro Lys Gly Glu Pro Gly Ile Ala 
    210                 215                 220                 


Gly His Arg Gly Pro Thr Gly Arg Pro Gly Lys Arg Gly Lys Gln Gly 
225                 230                 235                 240 


Gln Lys Gly Asp Ser Gly Val Met Gly Pro Pro Gly Lys Pro Gly Pro 
                245                 250                 255     


Ser Gly Gln Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Pro Ala Gly 
            260                 265                 270         


Gln Leu Ile Met Gly Pro Lys Gly Glu Arg Gly Phe Pro Gly Pro Pro 
        275                 280                 285             


Gly Arg Cys Leu Cys Gly Pro Thr Met Asn Val Asn Asn Pro Ser Tyr 
    290                 295                 300                 


Gly Glu Ser Val Tyr Gly Pro Ser Ser Pro Arg Val Pro Val Ile Phe 
305                 310                 315                 320 


Val Val Asn Asn Gln Glu Glu Leu Glu Arg Leu Asn Thr Gln Asn Ala 
                325                 330                 335     


Ile Ala Phe Arg Arg Asp Gln Arg Ser Leu Tyr Phe Lys Asp Ser Leu 
            340                 345                 350         


Gly Trp Leu Pro Ile Gln Leu Thr Pro Phe Tyr Pro Val Asp Tyr Thr 
        355                 360                 365             


Ala Asp Gln His Gly Thr Cys Gly Asp Gly Leu Leu Gln Pro Gly Glu 
    370                 375                 380                 


Glu Cys Asp Asp Gly Asn Ser Asp Val Gly Asp Asp Cys Ile Arg Cys 
385                 390                 395                 400 


His Arg Ala Tyr Cys Gly Asp Gly His Arg His Glu Gly Val Glu Asp 
                405                 410                 415     


Cys Asp Gly Ser Asp Phe Gly Tyr Leu Thr Cys Glu Thr Tyr Leu Pro 
            420                 425                 430         


Gly Ser Tyr Gly Asp Leu Gln Cys Thr Gln Tyr Cys Tyr Ile Asp Ser 
        435                 440                 445             


Thr Pro Cys Arg Tyr Phe Thr 
    450                 455 


<210>  2443
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMMD10__Homo_sapiens__NP_057228

<400>  2443

Met Ala Val Pro Ala Ala Leu Ile Leu Arg Glu Ser Pro Ser Met Lys 
1               5                   10                  15      


Lys Ala Val Ser Leu Ile Asn Ala Ile Asp Thr Gly Arg Phe Pro Arg 
            20                  25                  30          


Leu Leu Thr Arg Ile Leu Gln Lys Leu His Leu Lys Ala Glu Ser Ser 
        35                  40                  45              


Phe Ser Glu Glu Glu Glu Glu Lys Leu Gln Ala Ala Phe Ser Leu Glu 
    50                  55                  60                  


Lys Gln Asp Leu His Leu Val Leu Glu Thr Ile Ser Phe Ile Leu Glu 
65                  70                  75                  80  


Gln Ala Val Tyr His Asn Val Lys Pro Ala Ala Leu Gln Gln Gln Leu 
                85                  90                  95      


Glu Asn Ile His Leu Arg Gln Asp Lys Ala Glu Ala Phe Val Asn Thr 
            100                 105                 110         


Trp Ser Ser Met Gly Gln Glu Thr Val Glu Lys Phe Arg Gln Arg Ile 
        115                 120                 125             


Leu Ala Pro Cys Lys Leu Glu Thr Val Gly Trp Gln Leu Asn Leu Gln 
    130                 135                 140                 


Met Ala His Ser Ala Gln Ala Lys Leu Lys Ser Pro Gln Ala Val Leu 
145                 150                 155                 160 


Gln Leu Gly Val Asn Asn Glu Asp Ser Lys Ser Leu Glu Lys Val Leu 
                165                 170                 175     


Val Glu Phe Ser His Lys Glu Leu Phe Asp Phe Tyr Asn Lys Leu Glu 
            180                 185                 190         


Thr Ile Gln Ala Gln Leu Asp Ser Leu Thr 
        195                 200         


<210>  2444
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMMD1__Homo_sapiens__NP_689729

<400>  2444

Met Ala Ala Gly Glu Leu Glu Gly Gly Lys Pro Leu Ser Gly Leu Leu 
1               5                   10                  15      


Asn Ala Leu Ala Gln Asp Thr Phe His Gly Tyr Pro Gly Ile Thr Glu 
            20                  25                  30          


Glu Leu Leu Arg Ser Gln Leu Tyr Pro Glu Val Pro Pro Glu Glu Phe 
        35                  40                  45              


Arg Pro Phe Leu Ala Lys Met Arg Gly Ile Leu Lys Ser Ile Ala Ser 
    50                  55                  60                  


Ala Asp Met Asp Phe Asn Gln Leu Glu Ala Phe Leu Thr Ala Gln Thr 
65                  70                  75                  80  


Lys Lys Gln Gly Gly Ile Thr Ser Asp Gln Ala Ala Val Ile Ser Lys 
                85                  90                  95      


Phe Trp Lys Ser His Lys Thr Lys Ile Arg Glu Ser Leu Met Asn Gln 
            100                 105                 110         


Ser Arg Trp Asn Ser Gly Leu Arg Gly Leu Ser Trp Arg Val Asp Gly 
        115                 120                 125             


Lys Ser Gln Ser Arg His Ser Ala Gln Ile His Thr Pro Val Ala Ile 
    130                 135                 140                 


Ile Glu Leu Glu Leu Gly Lys Tyr Gly Gln Glu Ser Glu Phe Leu Cys 
145                 150                 155                 160 


Leu Glu Phe Asp Glu Val Lys Val Asn Gln Ile Leu Lys Thr Leu Ser 
                165                 170                 175     


Glu Val Glu Glu Ser Ile Ser Thr Leu Ile Ser Gln Pro Asn 
            180                 185                 190 


<210>  2445
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMMD3-BMI1__Homo_sapiens__NP_001190991

<400>  2445

Met Glu Leu Ser Glu Ser Val Gln Lys Gly Phe Gln Met Leu Ala Asp 
1               5                   10                  15      


Pro Arg Ser Phe Asp Ser Asn Ala Phe Thr Leu Leu Leu Arg Ala Ala 
            20                  25                  30          


Phe Gln Ser Leu Leu Asp Ala Gln Ala Asp Glu Ala Val Leu Asp His 
        35                  40                  45              


Pro Asp Leu Lys His Ile Asp Pro Val Val Leu Lys His Cys His Ala 
    50                  55                  60                  


Ala Ala Ala Thr Tyr Ile Leu Glu Ala Gly Lys His Arg Ala Asp Lys 
65                  70                  75                  80  


Ser Thr Leu Ser Thr Tyr Leu Glu Asp Cys Lys Phe Asp Arg Glu Arg 
                85                  90                  95      


Ile Glu Leu Phe Cys Thr Glu Tyr Gln Asn Asn Lys Asn Ser Leu Glu 
            100                 105                 110         


Ile Leu Leu Gly Arg Thr Leu Ile Pro His Pro Ile Gln Arg Leu Val 
        115                 120                 125             


Leu Val Ala Ala Trp Asn Asn Tyr Arg Ile Phe Tyr Gln Ala Glu Met 
    130                 135                 140                 


His Arg Thr Thr Arg Ile Lys Ile Thr Glu Leu Asn Pro His Leu Met 
145                 150                 155                 160 


Cys Val Leu Cys Gly Gly Tyr Phe Ile Asp Ala Thr Thr Ile Ile Glu 
                165                 170                 175     


Cys Leu His Ser Phe Cys Lys Thr Cys Ile Val Arg Tyr Leu Glu Thr 
            180                 185                 190         


Ser Lys Tyr Cys Pro Ile Cys Asp Val Gln Val His Lys Thr Arg Pro 
        195                 200                 205             


Leu Leu Asn Ile Arg Ser Asp Lys Thr Leu Gln Asp Ile Val Tyr Lys 
    210                 215                 220                 


Leu Val Pro Gly Leu Phe Lys Asn Glu Met Lys Arg Arg Arg Asp Phe 
225                 230                 235                 240 


Tyr Ala Ala His Pro Ser Ala Asp Ala Ala Asn Gly Ser Asn Glu Asp 
                245                 250                 255     


Arg Gly Glu Val Ala Asp Glu Asp Lys Arg Ile Ile Thr Asp Asp Glu 
            260                 265                 270         


Ile Ile Ser Leu Ser Ile Glu Phe Phe Asp Gln Asn Arg Leu Asp Arg 
        275                 280                 285             


Lys Val Asn Lys Asp Lys Glu Lys Ser Lys Glu Glu Val Asn Asp Lys 
    290                 295                 300                 


Arg Tyr Leu Arg Cys Pro Ala Ala Met Thr Val Met His Leu Arg Lys 
305                 310                 315                 320 


Phe Leu Arg Ser Lys Met Asp Ile Pro Asn Thr Phe Gln Ile Asp Val 
                325                 330                 335     


Met Tyr Glu Glu Glu Pro Leu Lys Asp Tyr Tyr Thr Leu Met Asp Ile 
            340                 345                 350         


Ala Tyr Ile Tyr Thr Trp Arg Arg Asn Gly Pro Leu Pro Leu Lys Tyr 
        355                 360                 365             


Arg Val Arg Pro Thr Cys Lys Arg Met Lys Ile Ser His Gln Arg Asp 
    370                 375                 380                 


Gly Leu Thr Asn Ala Gly Glu Leu Glu Ser Asp Ser Gly Ser Asp Lys 
385                 390                 395                 400 


Ala Asn Ser Pro Ala Gly Gly Ile Pro Ser Thr Ser Ser Cys Leu Pro 
                405                 410                 415     


Ser Pro Ser Thr Pro Val Gln Ser Pro His Pro Gln Phe Pro His Ile 
            420                 425                 430         


Ser Ser Thr Met Asn Gly Thr Ser Asn Ser Pro Ser Gly Asn His Gln 
        435                 440                 445             


Ser Ser Phe Ala Asn Arg Pro Arg Lys Ser Ser Val Asn Gly Ser Ser 
    450                 455                 460                 


Ala Thr Ser Ser Gly 
465                 


<210>  2446
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMMD5__Homo_sapiens__NP_054785

<400>  2446

Met Ser Ala Val Gly Ala Ala Thr Pro Tyr Leu His His Pro Gly Asp 
1               5                   10                  15      


Ser His Ser Gly Arg Val Ser Phe Leu Gly Ala Gln Leu Pro Pro Glu 
            20                  25                  30          


Val Ala Ala Met Ala Arg Leu Leu Gly Asp Leu Asp Arg Ser Thr Phe 
        35                  40                  45              


Arg Lys Leu Leu Lys Phe Val Val Ser Ser Leu Gln Gly Glu Asp Cys 
    50                  55                  60                  


Arg Glu Ala Val Gln Arg Leu Gly Val Ser Ala Asn Leu Pro Glu Glu 
65                  70                  75                  80  


Gln Leu Gly Ala Leu Leu Ala Gly Met His Thr Leu Leu Gln Gln Ala 
                85                  90                  95      


Leu Arg Leu Pro Pro Thr Ser Leu Lys Pro Asp Thr Phe Arg Asp Gln 
            100                 105                 110         


Leu Gln Glu Leu Cys Ile Pro Gln Asp Leu Val Gly Asp Leu Ala Ser 
        115                 120                 125             


Val Val Phe Gly Ser Gln Arg Pro Leu Leu Asp Ser Val Ala Gln Gln 
    130                 135                 140                 


Gln Gly Ala Trp Leu Pro His Val Ala Asp Phe Arg Trp Arg Val Asp 
145                 150                 155                 160 


Val Ala Ile Ser Thr Ser Ala Leu Ala Arg Ser Leu Gln Pro Ser Val 
                165                 170                 175     


Leu Met Gln Leu Lys Leu Ser Asp Gly Ser Ala Tyr Arg Phe Glu Val 
            180                 185                 190         


Pro Thr Ala Lys Phe Gln Glu Leu Arg Tyr Ser Val Ala Leu Val Leu 
        195                 200                 205             


Lys Glu Met Ala Asp Leu Glu Lys Arg Cys Glu Arg Arg Leu Gln Asp 
    210                 215                 220                 


<210>  2447
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMMD7__Homo_sapiens__NP_001092809

<400>  2447

Met Gly Arg Leu His Cys Thr Glu Asp Pro Val Pro Glu Ala Val Gly 
1               5                   10                  15      


Gly Asp Met Gln Gln Leu Asn Gln Leu Gly Ala Gln Phe Ser Ala Leu 
            20                  25                  30          


Thr Glu Val Leu Phe His Phe Leu Thr Glu Pro Lys Glu Val Glu Arg 
        35                  40                  45              


Phe Leu Ala Gln Leu Ser Glu Phe Ala Thr Thr Asn Gln Ile Ser Leu 
    50                  55                  60                  


Gly Ser Leu Arg Ser Ile Val Lys Ser Leu Leu Leu Val Pro Asn Gly 
65                  70                  75                  80  


Ala Leu Lys Lys Ser Leu Thr Ala Lys Gln Val Gln Ala Asp Phe Ile 
                85                  90                  95      


Thr Leu Gly Leu Ser Glu Glu Lys Ala Thr Tyr Phe Ser Glu Lys Trp 
            100                 105                 110         


Lys Gln Asn Ala Pro Thr Leu Ala Arg Trp Ala Ile Gly Gln Thr Leu 
        115                 120                 125             


Met Ile Asn Gln Leu Ile Asp Met Glu Trp Lys Phe Gly Val Thr Ser 
    130                 135                 140                 


Gly Ser Ser Glu Leu Glu Lys Val Gly Ser Ile Phe Leu Gln Leu Lys 
145                 150                 155                 160 


Leu Val Val Lys Lys Gly Asn Gln Thr Glu Asn Val Tyr Ile Glu Leu 
                165                 170                 175     


Thr Leu Pro Gln Phe Tyr Ser Phe Leu His Glu Met Glu Arg Val Arg 
            180                 185                 190         


Thr Ser Met Glu Cys Phe Cys 
        195                 


<210>  2448
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMP__Homo_sapiens__NP_000086

<400>  2448

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210>  2449
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMT__Homo_sapiens__NP_001128634

<400>  2449

Met Pro Glu Ala Pro Pro Leu Leu Leu Ala Ala Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Leu Val Val Leu Leu Leu Leu Leu Arg His Trp Gly Trp Gly 
            20                  25                  30          


Leu Cys Leu Ile Gly Trp Asn Glu Phe Ile Leu Gln Pro Ile His Asn 
        35                  40                  45              


Leu Leu Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu 
    50                  55                  60                  


Gln His Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp 
65                  70                  75                  80  


Thr Tyr Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys 
                85                  90                  95      


Gly Lys Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu 
            100                 105                 110         


Leu Glu Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg 
        115                 120                 125             


Leu Leu Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp 
    130                 135                 140                 


Cys Ala Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp 
145                 150                 155                 160 


Lys Val Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu 
                165                 170                 175     


Lys Lys Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His 
            180                 185                 190         


Trp Lys Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly 
        195                 200                 205             


Leu Leu Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro 
    210                 215                 220                 


Gly Ala Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu 
225                 230                 235                 240 


Cys Thr His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly 
                245                 250                 255     


Leu Glu Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
            260                 265                 270     


<210>  2450
<211>  1233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPA__Homo_sapiens__NP_001091868

<400>  2450

Met Leu Thr Lys Phe Glu Thr Lys Ser Ala Arg Val Lys Gly Leu Ser 
1               5                   10                  15      


Phe His Pro Lys Arg Pro Trp Ile Leu Thr Ser Leu His Asn Gly Val 
            20                  25                  30          


Ile Gln Leu Trp Asp Tyr Arg Met Cys Thr Leu Ile Asp Lys Phe Asp 
        35                  40                  45              


Glu His Asp Gly Pro Val Arg Gly Ile Asp Phe His Lys Gln Gln Pro 
    50                  55                  60                  


Leu Phe Val Ser Gly Gly Asp Asp Tyr Lys Ile Lys Val Trp Asn Tyr 
65                  70                  75                  80  


Lys Leu Arg Arg Cys Leu Phe Thr Leu Leu Gly His Leu Asp Tyr Ile 
                85                  90                  95      


Arg Thr Thr Phe Phe His His Glu Tyr Pro Trp Ile Leu Ser Ala Ser 
            100                 105                 110         


Asp Asp Gln Thr Ile Arg Val Trp Asn Trp Gln Ser Arg Thr Cys Val 
        115                 120                 125             


Cys Val Leu Thr Gly His Asn His Tyr Val Met Cys Ala Gln Phe His 
    130                 135                 140                 


Pro Thr Glu Asp Leu Val Val Ser Ala Ser Leu Asp Gln Thr Val Arg 
145                 150                 155                 160 


Val Trp Asp Ile Ser Gly Leu Arg Lys Lys Asn Leu Ser Pro Gly Ala 
                165                 170                 175     


Val Glu Ser Asp Val Arg Gly Ile Thr Gly Val Asp Leu Phe Gly Thr 
            180                 185                 190         


Thr Asp Ala Val Val Lys His Val Leu Glu Gly His Asp Arg Gly Val 
        195                 200                 205             


Asn Trp Ala Ala Phe His Pro Thr Met Pro Leu Ile Val Ser Gly Ala 
    210                 215                 220                 


Asp Asp Arg Gln Val Lys Ile Trp Arg Met Asn Glu Ser Lys Ala Trp 
225                 230                 235                 240 


Glu Val Asp Thr Cys Arg Gly His Tyr Asn Asn Val Ser Cys Ala Val 
                245                 250                 255     


Phe His Pro Arg Gln Glu Leu Ile Leu Ser Asn Ser Glu Asp Lys Ser 
            260                 265                 270         


Ile Arg Val Trp Asp Met Ser Lys Arg Thr Gly Val Gln Thr Phe Arg 
        275                 280                 285             


Arg Asp His Asp Arg Phe Trp Val Leu Ala Ala His Pro Asn Leu Asn 
    290                 295                 300                 


Leu Phe Ala Ala Gly His Asp Gly Gly Met Ile Val Phe Lys Leu Glu 
305                 310                 315                 320 


Arg Glu Arg Pro Ala Tyr Ala Val His Gly Asn Met Leu His Tyr Val 
                325                 330                 335     


Lys Asp Arg Phe Leu Arg Gln Leu Asp Phe Asn Ser Ser Lys Asp Val 
            340                 345                 350         


Ala Val Met Gln Leu Arg Ser Gly Ser Lys Phe Pro Val Phe Asn Met 
        355                 360                 365             


Ser Tyr Asn Pro Ala Glu Asn Ala Val Leu Leu Cys Thr Arg Ala Ser 
    370                 375                 380                 


Asn Leu Glu Asn Ser Thr Tyr Asp Leu Tyr Thr Ile Pro Lys Asp Ala 
385                 390                 395                 400 


Asp Ser Gln Asn Pro Asp Ala Pro Glu Gly Lys Arg Ser Ser Gly Leu 
                405                 410                 415     


Thr Ala Val Trp Val Ala Arg Asn Arg Phe Ala Val Leu Asp Arg Met 
            420                 425                 430         


His Ser Leu Leu Ile Lys Asn Leu Lys Asn Glu Ile Thr Lys Lys Val 
        435                 440                 445             


Gln Val Pro Asn Cys Asp Glu Ile Phe Tyr Ala Gly Thr Gly Asn Leu 
    450                 455                 460                 


Leu Leu Arg Asp Ala Asp Ser Ile Thr Leu Phe Asp Val Gln Gln Lys 
465                 470                 475                 480 


Arg Thr Leu Ala Ser Val Lys Ile Ser Lys Val Lys Tyr Val Ile Trp 
                485                 490                 495     


Ser Ala Asp Met Ser His Val Ala Leu Leu Ala Lys His Glu His Ser 
            500                 505                 510         


Cys Pro Leu Pro Leu Thr Ala Ile Val Ile Cys Asn Arg Lys Leu Asp 
        515                 520                 525             


Ala Leu Cys Asn Ile His Glu Asn Ile Arg Val Lys Ser Gly Ala Trp 
    530                 535                 540                 


Asp Glu Ser Gly Val Phe Ile Tyr Thr Thr Ser Asn His Ile Lys Tyr 
545                 550                 555                 560 


Ala Val Thr Thr Gly Asp His Gly Ile Ile Arg Thr Leu Asp Leu Pro 
                565                 570                 575     


Ile Tyr Val Thr Arg Val Lys Gly Asn Asn Val Tyr Cys Leu Asp Arg 
            580                 585                 590         


Glu Cys Arg Pro Arg Val Leu Thr Ile Asp Pro Thr Glu Phe Lys Phe 
        595                 600                 605             


Lys Leu Ala Leu Ile Asn Arg Lys Tyr Asp Glu Val Leu His Met Val 
    610                 615                 620                 


Arg Asn Ala Lys Leu Val Gly Gln Ser Ile Ile Ala Tyr Leu Gln Lys 
625                 630                 635                 640 


Lys Gly Tyr Pro Glu Val Ala Leu His Phe Val Lys Asp Glu Lys Thr 
                645                 650                 655     


Arg Phe Ser Leu Ala Leu Glu Cys Gly Asn Ile Glu Ile Ala Leu Glu 
            660                 665                 670         


Ala Ala Lys Ala Leu Asp Asp Lys Asn Cys Trp Glu Lys Leu Gly Glu 
        675                 680                 685             


Val Ala Leu Leu Gln Gly Asn His Gln Ile Val Glu Met Cys Tyr Gln 
    690                 695                 700                 


Arg Thr Lys Asn Phe Asp Lys Leu Ser Phe Leu Tyr Leu Ile Thr Gly 
705                 710                 715                 720 


Asn Leu Glu Lys Leu Arg Lys Met Met Lys Ile Ala Glu Ile Arg Lys 
                725                 730                 735     


Asp Met Ser Gly His Tyr Gln Asn Ala Leu Tyr Leu Gly Asp Val Ser 
            740                 745                 750         


Glu Arg Val Arg Ile Leu Lys Asn Cys Gly Gln Lys Ser Leu Ala Tyr 
        755                 760                 765             


Leu Thr Ala Ala Thr His Gly Leu Asp Glu Glu Ala Glu Ser Leu Lys 
    770                 775                 780                 


Glu Thr Phe Asp Pro Glu Lys Glu Thr Ile Pro Asp Ile Asp Pro Asn 
785                 790                 795                 800 


Ala Lys Leu Leu Gln Pro Pro Ala Pro Ile Met Pro Leu Asp Thr Asn 
                805                 810                 815     


Trp Pro Leu Leu Thr Val Ser Lys Gly Phe Phe Glu Gly Thr Ile Ala 
            820                 825                 830         


Ser Lys Gly Lys Gly Gly Ala Leu Ala Ala Asp Ile Asp Ile Asp Thr 
        835                 840                 845             


Val Gly Thr Glu Gly Trp Gly Glu Asp Ala Glu Leu Gln Leu Asp Glu 
    850                 855                 860                 


Asp Gly Phe Val Glu Ala Thr Glu Gly Leu Gly Asp Asp Ala Leu Gly 
865                 870                 875                 880 


Lys Gly Gln Glu Glu Gly Gly Gly Trp Asp Val Glu Glu Asp Leu Glu 
                885                 890                 895     


Leu Pro Pro Glu Leu Asp Ile Ser Pro Gly Ala Ala Gly Gly Ala Glu 
            900                 905                 910         


Asp Gly Phe Phe Val Pro Pro Thr Lys Gly Thr Ser Pro Thr Gln Ile 
        915                 920                 925             


Trp Cys Asn Asn Ser Gln Leu Pro Val Asp His Ile Leu Ala Gly Ser 
    930                 935                 940                 


Phe Glu Thr Ala Met Arg Leu Leu His Asp Gln Val Gly Val Ile Gln 
945                 950                 955                 960 


Phe Gly Pro Tyr Lys Gln Leu Phe Leu Gln Thr Tyr Ala Arg Gly Arg 
                965                 970                 975     


Thr Thr Tyr Gln Ala Leu Pro Cys Leu Pro Ser Met Tyr Gly Tyr Pro 
            980                 985                 990         


Asn Arg Asn Trp Lys Asp Ala Gly  Leu Lys Asn Gly Val  Pro Ala Val 
        995                 1000                 1005             


Gly Leu  Lys Leu Asn Asp Leu  Ile Gln Arg Leu Gln  Leu Cys Tyr 
    1010                 1015                 1020             


Gln Leu  Thr Thr Val Gly Lys  Phe Glu Glu Ala Val  Glu Lys Phe 
    1025                 1030                 1035             


Arg Ser  Ile Leu Leu Ser Val  Pro Leu Leu Val Val  Asp Asn Lys 
    1040                 1045                 1050             


Gln Glu  Ile Ala Glu Ala Gln  Gln Leu Ile Thr Ile  Cys Arg Glu 
    1055                 1060                 1065             


Tyr Ile  Val Gly Leu Ser Val  Glu Thr Glu Arg Lys  Lys Leu Pro 
    1070                 1075                 1080             


Lys Glu  Thr Leu Glu Gln Gln  Lys Arg Ile Cys Glu  Met Ala Ala 
    1085                 1090                 1095             


Tyr Phe  Thr His Ser Asn Leu  Gln Pro Val His Met  Ile Leu Val 
    1100                 1105                 1110             


Leu Arg  Thr Ala Leu Asn Leu  Phe Phe Lys Leu Lys  Asn Phe Lys 
    1115                 1120                 1125             


Thr Ala  Ala Thr Phe Ala Arg  Arg Leu Leu Glu Leu  Gly Pro Lys 
    1130                 1135                 1140             


Pro Glu  Val Ala Gln Gln Thr  Arg Lys Ile Leu Ser  Ala Cys Glu 
    1145                 1150                 1155             


Lys Asn  Pro Thr Asp Ala Tyr  Gln Leu Asn Tyr Asp  Met His Asn 
    1160                 1165                 1170             


Pro Phe  Asp Ile Cys Ala Ala  Ser Tyr Arg Pro Ile  Tyr Arg Gly 
    1175                 1180                 1185             


Lys Pro  Val Glu Lys Cys Pro  Leu Ser Gly Ala Cys  Tyr Ser Pro 
    1190                 1195                 1200             


Glu Phe  Lys Gly Gln Ile Cys  Arg Val Thr Thr Val  Thr Glu Ile 
    1205                 1210                 1215             


Gly Lys  Asp Val Ile Gly Leu  Arg Ile Ser Pro Leu  Gln Phe Arg 
    1220                 1225                 1230             


<210>  2451
<211>  953
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPB1__Homo_sapiens__NP_057535

<400>  2451

Met Thr Ala Ala Glu Asn Val Cys Tyr Thr Leu Ile Asn Val Pro Met 
1               5                   10                  15      


Asp Ser Glu Pro Pro Ser Glu Ile Ser Leu Lys Asn Asp Leu Glu Lys 
            20                  25                  30          


Gly Asp Val Lys Ser Lys Thr Glu Ala Leu Lys Lys Val Ile Ile Met 
        35                  40                  45              


Ile Leu Asn Gly Glu Lys Leu Pro Gly Leu Leu Met Thr Ile Ile Arg 
    50                  55                  60                  


Phe Val Leu Pro Leu Gln Asp His Thr Ile Lys Lys Leu Leu Leu Val 
65                  70                  75                  80  


Phe Trp Glu Ile Val Pro Lys Thr Thr Pro Asp Gly Arg Leu Leu His 
                85                  90                  95      


Glu Met Ile Leu Val Cys Asp Ala Tyr Arg Lys Asp Leu Gln His Pro 
            100                 105                 110         


Asn Glu Phe Ile Arg Gly Ser Thr Leu Arg Phe Leu Cys Lys Leu Lys 
        115                 120                 125             


Glu Ala Glu Leu Leu Glu Pro Leu Met Pro Ala Ile Arg Ala Cys Leu 
    130                 135                 140                 


Glu His Arg His Ser Tyr Val Arg Arg Asn Ala Val Leu Ala Ile Tyr 
145                 150                 155                 160 


Thr Ile Tyr Arg Asn Phe Glu His Leu Ile Pro Asp Ala Pro Glu Leu 
                165                 170                 175     


Ile His Asp Phe Leu Val Asn Glu Lys Asp Ala Ser Cys Lys Arg Asn 
            180                 185                 190         


Ala Phe Met Met Leu Ile His Ala Asp Gln Asp Arg Ala Leu Asp Tyr 
        195                 200                 205             


Leu Ser Thr Cys Ile Asp Gln Val Gln Thr Phe Gly Asp Ile Leu Gln 
    210                 215                 220                 


Leu Val Ile Val Glu Leu Ile Tyr Lys Val Cys His Ala Asn Pro Ser 
225                 230                 235                 240 


Glu Arg Ala Arg Phe Ile Arg Cys Ile Tyr Asn Leu Leu Gln Ser Ser 
                245                 250                 255     


Ser Pro Ala Val Lys Tyr Glu Ala Ala Gly Thr Leu Val Thr Leu Ser 
            260                 265                 270         


Ser Ala Pro Thr Ala Ile Lys Ala Ala Ala Gln Cys Tyr Ile Asp Leu 
        275                 280                 285             


Ile Ile Lys Glu Ser Asp Asn Asn Val Lys Leu Ile Val Leu Asp Arg 
    290                 295                 300                 


Leu Ile Glu Leu Lys Glu His Pro Ala His Glu Arg Val Leu Gln Asp 
305                 310                 315                 320 


Leu Val Met Asp Ile Leu Arg Val Leu Ser Thr Pro Asp Leu Glu Val 
                325                 330                 335     


Arg Lys Lys Thr Leu Gln Leu Ala Leu Asp Leu Val Ser Ser Arg Asn 
            340                 345                 350         


Val Glu Glu Leu Val Ile Val Leu Lys Lys Glu Val Ile Lys Thr Asn 
        355                 360                 365             


Asn Val Ser Glu His Glu Asp Thr Asp Lys Tyr Arg Gln Leu Leu Val 
    370                 375                 380                 


Arg Thr Leu His Ser Cys Ser Val Arg Phe Pro Asp Met Ala Ala Asn 
385                 390                 395                 400 


Val Ile Pro Val Leu Met Glu Phe Leu Ser Asp Asn Asn Glu Ala Ala 
                405                 410                 415     


Ala Ala Asp Val Leu Glu Phe Val Arg Glu Ala Ile Gln Arg Phe Asp 
            420                 425                 430         


Asn Leu Arg Met Leu Ile Val Glu Lys Met Leu Glu Val Phe His Ala 
        435                 440                 445             


Ile Lys Ser Val Lys Ile Tyr Arg Gly Ala Leu Trp Ile Leu Gly Glu 
    450                 455                 460                 


Tyr Cys Ser Thr Lys Glu Asp Ile Gln Ser Val Met Thr Glu Ile Arg 
465                 470                 475                 480 


Arg Ser Leu Gly Glu Ile Pro Ile Val Glu Ser Glu Ile Lys Lys Glu 
                485                 490                 495     


Ala Gly Glu Leu Lys Pro Glu Glu Glu Ile Thr Val Gly Pro Val Gln 
            500                 505                 510         


Lys Leu Val Thr Glu Met Gly Thr Tyr Ala Thr Gln Ser Ala Leu Ser 
        515                 520                 525             


Ser Ser Arg Pro Thr Lys Lys Glu Glu Asp Arg Pro Pro Leu Arg Gly 
    530                 535                 540                 


Phe Leu Leu Asp Gly Asp Phe Phe Val Ala Ala Ser Leu Ala Thr Thr 
545                 550                 555                 560 


Leu Thr Lys Ile Ala Leu Arg Tyr Val Ala Leu Val Gln Glu Lys Lys 
                565                 570                 575     


Lys Gln Asn Ser Phe Val Ala Glu Ala Met Leu Leu Met Ala Thr Ile 
            580                 585                 590         


Leu His Leu Gly Lys Ser Ser Leu Pro Lys Lys Pro Ile Thr Asp Asp 
        595                 600                 605             


Asp Val Asp Arg Ile Ser Leu Cys Leu Lys Val Leu Ser Glu Cys Ser 
    610                 615                 620                 


Pro Leu Met Asn Asp Ile Phe Asn Lys Glu Cys Arg Gln Ser Leu Ser 
625                 630                 635                 640 


His Met Leu Ser Ala Lys Leu Glu Glu Glu Lys Leu Ser Gln Lys Lys 
                645                 650                 655     


Glu Ser Glu Lys Arg Asn Val Thr Val Gln Pro Asp Asp Pro Ile Ser 
            660                 665                 670         


Phe Met Gln Leu Thr Ala Lys Asn Glu Met Asn Cys Lys Glu Asp Gln 
        675                 680                 685             


Phe Gln Leu Ser Leu Leu Ala Ala Met Gly Asn Thr Gln Arg Lys Glu 
    690                 695                 700                 


Ala Ala Asp Pro Leu Ala Ser Lys Leu Asn Lys Val Thr Gln Leu Thr 
705                 710                 715                 720 


Gly Phe Ser Asp Pro Val Tyr Ala Glu Ala Tyr Val His Val Asn Gln 
                725                 730                 735     


Tyr Asp Ile Val Leu Asp Val Leu Val Val Asn Gln Thr Ser Asp Thr 
            740                 745                 750         


Leu Gln Asn Cys Thr Leu Glu Leu Ala Thr Leu Gly Asp Leu Lys Leu 
        755                 760                 765             


Val Glu Lys Pro Ser Pro Leu Thr Leu Ala Pro His Asp Phe Ala Asn 
    770                 775                 780                 


Ile Lys Ala Asn Val Lys Val Ala Ser Thr Glu Asn Gly Ile Ile Phe 
785                 790                 795                 800 


Gly Asn Ile Val Tyr Asp Val Ser Gly Ala Ala Ser Asp Arg Asn Cys 
                805                 810                 815     


Val Val Leu Ser Asp Ile His Ile Asp Ile Met Asp Tyr Ile Gln Pro 
            820                 825                 830         


Ala Thr Cys Thr Asp Ala Glu Phe Arg Gln Met Trp Ala Glu Phe Glu 
        835                 840                 845             


Trp Glu Asn Lys Val Thr Val Asn Thr Asn Met Val Asp Leu Asn Asp 
    850                 855                 860                 


Tyr Leu Gln His Ile Leu Lys Ser Thr Asn Met Lys Cys Leu Thr Pro 
865                 870                 875                 880 


Glu Lys Ala Leu Ser Gly Tyr Cys Gly Phe Met Ala Ala Asn Leu Tyr 
                885                 890                 895     


Ala Arg Ser Ile Phe Gly Glu Asp Ala Leu Ala Asn Val Ser Ile Glu 
            900                 905                 910         


Lys Pro Ile His Gln Gly Pro Asp Ala Ala Val Thr Gly His Ile Arg 
        915                 920                 925             


Ile Arg Ala Lys Ser Gln Gly Met Ala Leu Ser Leu Gly Asp Lys Ile 
    930                 935                 940                 


Asn Leu Ser Gln Lys Lys Thr Ser Ile 
945                 950             


<210>  2452
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPB2__Homo_sapiens__NP_004757

<400>  2452

Met Pro Leu Arg Leu Asp Ile Lys Arg Lys Leu Thr Ala Arg Ser Asp 
1               5                   10                  15      


Arg Val Lys Ser Val Asp Leu His Pro Thr Glu Pro Trp Met Leu Ala 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu Thr Gln Thr 
        35                  40                  45              


Leu Val Lys Thr Phe Glu Val Cys Asp Leu Pro Val Arg Ala Ala Lys 
    50                  55                  60                  


Phe Val Ala Arg Lys Asn Trp Val Val Thr Gly Ala Asp Asp Met Gln 
65                  70                  75                  80  


Ile Arg Val Phe Asn Tyr Asn Thr Leu Glu Arg Val His Met Phe Glu 
                85                  90                  95      


Ala His Ser Asp Tyr Ile Arg Cys Ile Ala Val His Pro Thr Gln Pro 
            100                 105                 110         


Phe Ile Leu Thr Ser Ser Asp Asp Met Leu Ile Lys Leu Trp Asp Trp 
        115                 120                 125             


Asp Lys Lys Trp Ser Cys Ser Gln Val Phe Glu Gly His Thr His Tyr 
    130                 135                 140                 


Val Met Gln Ile Val Ile Asn Pro Lys Asp Asn Asn Gln Phe Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Asp Arg Thr Ile Lys Val Trp Gln Leu Gly Ser Ser Ser 
                165                 170                 175     


Pro Asn Phe Thr Leu Glu Gly His Glu Lys Gly Val Asn Cys Ile Asp 
            180                 185                 190         


Tyr Tyr Ser Gly Gly Asp Lys Pro Tyr Leu Ile Ser Gly Ala Asp Asp 
        195                 200                 205             


Arg Leu Val Lys Ile Trp Asp Tyr Gln Asn Lys Thr Cys Val Gln Thr 
    210                 215                 220                 


Leu Glu Gly His Ala Gln Asn Val Ser Cys Ala Ser Phe His Pro Glu 
225                 230                 235                 240 


Leu Pro Ile Ile Ile Thr Gly Ser Glu Asp Gly Thr Val Arg Ile Trp 
                245                 250                 255     


His Ser Ser Thr Tyr Arg Leu Glu Ser Thr Leu Asn Tyr Gly Met Glu 
            260                 265                 270         


Arg Val Trp Cys Val Ala Ser Leu Arg Gly Ser Asn Asn Val Ala Leu 
        275                 280                 285             


Gly Tyr Asp Glu Gly Ser Ile Ile Val Lys Leu Gly Arg Glu Glu Pro 
    290                 295                 300                 


Ala Met Ser Met Asp Ala Asn Gly Lys Ile Ile Trp Ala Lys His Ser 
305                 310                 315                 320 


Glu Val Gln Gln Ala Asn Leu Lys Ala Met Gly Asp Ala Glu Ile Lys 
                325                 330                 335     


Asp Gly Glu Arg Leu Pro Leu Ala Val Lys Asp Met Gly Ser Cys Glu 
            340                 345                 350         


Ile Tyr Pro Gln Thr Ile Gln His Asn Pro Asn Gly Arg Phe Val Val 
        355                 360                 365             


Val Cys Gly Asp Gly Glu Tyr Ile Ile Tyr Thr Ala Met Ala Leu Arg 
    370                 375                 380                 


Asn Lys Ser Phe Gly Ser Ala Gln Glu Phe Ala Trp Ala His Asp Ser 
385                 390                 395                 400 


Ser Glu Tyr Ala Ile Arg Glu Ser Asn Ser Ile Val Lys Ile Phe Lys 
                405                 410                 415     


Asn Phe Lys Glu Lys Lys Ser Phe Lys Pro Asp Phe Gly Ala Glu Ser 
            420                 425                 430         


Ile Tyr Gly Gly Phe Leu Leu Gly Val Arg Ser Val Asn Gly Leu Ala 
        435                 440                 445             


Phe Tyr Asp Trp Asp Asn Thr Glu Leu Ile Arg Arg Ile Glu Ile Gln 
    450                 455                 460                 


Pro Lys His Ile Phe Trp Ser Asp Ser Gly Glu Leu Val Cys Ile Ala 
465                 470                 475                 480 


Thr Glu Glu Ser Phe Phe Ile Leu Lys Tyr Leu Ser Glu Lys Val Leu 
                485                 490                 495     


Ala Ala Gln Glu Thr His Glu Gly Val Thr Glu Asp Gly Ile Glu Asp 
            500                 505                 510         


Ala Phe Glu Val Leu Gly Glu Ile Gln Glu Ile Val Lys Thr Gly Leu 
        515                 520                 525             


Trp Val Gly Asp Cys Phe Ile Tyr Thr Ser Ser Val Asn Arg Leu Asn 
    530                 535                 540                 


Tyr Tyr Val Gly Gly Glu Ile Val Thr Ile Ala His Leu Asp Arg Thr 
545                 550                 555                 560 


Met Tyr Leu Leu Gly Tyr Ile Pro Lys Asp Asn Arg Leu Tyr Leu Gly 
                565                 570                 575     


Asp Lys Glu Leu Asn Ile Ile Ser Tyr Ser Leu Leu Val Ser Val Leu 
            580                 585                 590         


Glu Tyr Gln Thr Ala Val Met Arg Arg Asp Phe Ser Met Ala Asp Lys 
        595                 600                 605             


Val Leu Pro Thr Ile Pro Lys Glu Gln Arg Thr Arg Val Ala His Phe 
    610                 615                 620                 


Leu Glu Lys Gln Gly Phe Lys Gln Gln Ala Leu Thr Val Ser Thr Asp 
625                 630                 635                 640 


Pro Glu His Arg Phe Glu Leu Ala Leu Gln Leu Gly Glu Leu Lys Ile 
                645                 650                 655     


Ala Tyr Gln Leu Ala Val Glu Ala Glu Ser Glu Gln Lys Trp Lys Gln 
            660                 665                 670         


Leu Ala Glu Leu Ala Ile Ser Lys Cys Gln Phe Gly Leu Ala Gln Glu 
        675                 680                 685             


Cys Leu His His Ala Gln Asp Tyr Gly Gly Leu Leu Leu Leu Ala Thr 
    690                 695                 700                 


Ala Ser Gly Asn Ala Asn Met Val Asn Lys Leu Ala Glu Gly Ala Glu 
705                 710                 715                 720 


Arg Asp Gly Lys Asn Asn Val Ala Phe Met Ser Tyr Phe Leu Gln Gly 
                725                 730                 735     


Lys Val Asp Ala Cys Leu Glu Leu Leu Ile Arg Thr Gly Arg Leu Pro 
            740                 745                 750         


Glu Ala Ala Phe Leu Ala Arg Thr Tyr Leu Pro Ser Gln Val Ser Arg 
        755                 760                 765             


Val Val Lys Leu Trp Arg Glu Asn Leu Ser Lys Val Asn Gln Lys Ala 
    770                 775                 780                 


Ala Glu Ser Leu Ala Asp Pro Thr Glu Tyr Glu Asn Leu Phe Pro Gly 
785                 790                 795                 800 


Leu Lys Glu Ala Phe Val Val Glu Glu Trp Val Lys Glu Thr His Ala 
                805                 810                 815     


Asp Leu Trp Pro Ala Lys Gln Tyr Pro Leu Val Thr Pro Asn Glu Glu 
            820                 825                 830         


Arg Asn Val Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr 
        835                 840                 845             


Ala Gln Gln Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile 
    850                 855                 860                 


Val Ala Ser His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu 
865                 870                 875                 880 


Glu Val Asp Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp 
                885                 890                 895     


Ile Asn Leu Asp Glu Asp Ile Leu Asp Asp 
            900                 905     


<210>  2453
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPE__Homo_sapiens__NP_009194

<400>  2453

Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val 
1               5                   10                  15      


Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln 
            20                  25                  30          


Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg 
        35                  40                  45              


Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg 
    50                  55                  60                  


Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu 
65                  70                  75                  80  


Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg 
                85                  90                  95      


Arg Asp Ser Ile Val Ala Glu Leu Asp Arg Glu Met Ser Arg Ser Val 
            100                 105                 110         


Asp Val Thr Asn Thr Thr Phe Leu Leu Met Ala Ala Ser Ile Tyr Leu 
        115                 120                 125             


His Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala Leu His Gln Gly Asp 
    130                 135                 140                 


Ser Leu Glu Cys Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp 
145                 150                 155                 160 


Arg Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp 
                165                 170                 175     


Glu Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala 
            180                 185                 190         


Thr Gly Gly Glu Lys Leu Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met 
        195                 200                 205             


Ala Asp Lys Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala 
    210                 215                 220                 


Cys His Met Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln 
225                 230                 235                 240 


Glu Ala Leu Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu 
                245                 250                 255     


Ile Val Leu Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg 
            260                 265                 270         


Tyr Leu Ser Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys 
        275                 280                 285             


Glu Tyr Gln Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr 
    290                 295                 300                 


Ala Pro Ser Ala 
305             


<210>  2454
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPG2__Homo_sapiens__NP_001276962

<400>  2454

Met Ile Lys Lys Phe Asp Lys Lys Asp Glu Glu Ser Gly Ser Gly Ser 
1               5                   10                  15      


Asn Pro Phe Gln His Leu Glu Lys Ser Ala Val Leu Gln Glu Ala Arg 
            20                  25                  30          


Ile Phe Asn Glu Thr Pro Ile Asn Pro Arg Arg Cys Leu His Ile Leu 
        35                  40                  45              


Thr Lys Ile Leu Tyr Leu Leu Asn Gln Gly Glu His Phe Gly Thr Thr 
    50                  55                  60                  


Glu Ala Thr Glu Ala Phe Phe Ala Met Thr Arg Leu Phe Gln Ser Asn 
65                  70                  75                  80  


Asp Gln Thr Leu Arg Arg Met Cys Tyr Leu Thr Ile Lys Glu Met Ala 
                85                  90                  95      


Thr Ile Ser Glu Asp Val Ile Ile Val Thr Ser Ser Leu Thr Lys Asp 
            100                 105                 110         


Met Thr Gly Lys Glu Asp Val Tyr Arg Gly Pro Ala Ile Arg Ala Leu 
        115                 120                 125             


Cys Arg Ile Thr Asp Gly Thr Met Leu Gln Ala Ile Glu Arg Tyr Met 
    130                 135                 140                 


Lys Gln Ala Ile Val Asp Lys Val Ser Ser Val Ser Ser Ser Ala Leu 
145                 150                 155                 160 


Val Ser Ser Leu His Met Met Lys Ile Ser Tyr Asp Val Val Lys Arg 
                165                 170                 175     


Trp Ile Asn Glu Ala Gln Glu Ala Ala Ser Ser Asp Asn Ile Met Val 
            180                 185                 190         


Gln Tyr His Ala Leu Gly Val Leu Tyr His Leu Arg Lys Asn Asp Arg 
        195                 200                 205             


Leu Ala Val Ser Lys Met Leu Asn Lys Phe Thr Lys Ser Gly Leu Lys 
    210                 215                 220                 


Ser Gln Phe Ala Tyr Cys Met Leu Ile Arg Ile Ala Ser Arg Leu Leu 
225                 230                 235                 240 


Lys Glu Thr Glu Asp Gly His Glu Ser Pro Leu Phe Asp Phe Ile Glu 
                245                 250                 255     


Ser Cys Leu Arg Asn Lys His Glu Met Val Ile Tyr Glu Ala Ala Ser 
            260                 265                 270         


Ala Ile Ile His Leu Pro Asn Cys Thr Ala Arg Glu Leu Ala Pro Ala 
        275                 280                 285             


Val Ser Val Leu Gln Leu Phe Cys Ser Ser Pro Lys Pro Ala Leu Arg 
    290                 295                 300                 


Tyr Ala Ala Val Arg Thr Leu Asn Lys Val Ala Met Lys His Pro Ser 
305                 310                 315                 320 


Ala Val Thr Ala Cys Asn Leu Asp Leu Glu Asn Leu Ile Thr Asp Ser 
                325                 330                 335     


Asn Arg Ser Ile Ala Thr Leu Ala Ile Thr Thr Leu Leu Lys Thr Gly 
            340                 345                 350         


Ser Glu Ser Ser Val Asp Arg Leu Met Lys Gln Ile Ser Ser Phe Val 
        355                 360                 365             


Ser Glu Ile Ser Asp Glu Phe Lys Val Val Val Val Gln Ala Ile Ser 
    370                 375                 380                 


Ala Leu Cys Gln Lys Tyr Pro Arg Lys His Ser Val Met Met Thr Phe 
385                 390                 395                 400 


Leu Ser Asn Met Leu Arg Asp Asp Gly Gly Phe Glu Tyr Lys Arg Ala 
                405                 410                 415     


Ile Val Asp Cys Ile Ile Ser Ile Val Glu Glu Asn Pro Glu Ser Lys 
            420                 425                 430         


Glu Ala Gly Leu Ala His Leu Cys Glu Phe Ile Glu Asp Cys Glu His 
        435                 440                 445             


Thr Val Leu Ala Thr Lys Ile Leu His Leu Leu Gly Lys Glu Gly Pro 
    450                 455                 460                 


Arg Thr Pro Val Pro Ser Lys Tyr Ile Arg Phe Ile Phe Asn Arg Val 
465                 470                 475                 480 


Val Leu Glu Asn Glu Ala Val Arg Ala Ala Ala Val Ser Ala Leu Ala 
                485                 490                 495     


Lys Phe Gly Ala Gln Asn Glu Ser Leu Leu Pro Ser Ile Leu Val Leu 
            500                 505                 510         


Leu Gln Arg Cys Met Met Asp Thr Asp Asp Glu Val Arg Asp Arg Ala 
        515                 520                 525             


Thr Phe Tyr Leu Asn Val Leu Gln Gln Arg Gln Met Ala Leu Asn Ala 
    530                 535                 540                 


Thr Tyr Ile Phe Asn Gly Leu Thr Val Ser Val Pro Gly Met Glu Lys 
545                 550                 555                 560 


Ala Leu His Gln Tyr Thr Leu Glu Pro Ser Glu Lys Pro Phe Asp Met 
                565                 570                 575     


Lys Ser Ile Pro Leu Ala Met Ala Pro Val Phe Glu Gln Lys Ala Glu 
            580                 585                 590         


Ile Thr Leu Val Ala Thr Lys Pro Glu Lys Leu Ala Pro Ser Arg Gln 
        595                 600                 605             


Asp Ile Phe Gln Glu Gln Leu Ala Ala Ile Pro Glu Phe Leu Asn Ile 
    610                 615                 620                 


Gly Pro Leu Phe Lys Ser Ser Glu Pro Val Gln Leu Thr Glu Ala Glu 
625                 630                 635                 640 


Thr Glu Tyr Phe Val Arg Cys Ile Lys His Met Phe Thr Asn His Ile 
                645                 650                 655     


Val Phe Gln Phe Asp Cys Thr Asn Thr Leu Asn Asp Gln Leu Leu Glu 
            660                 665                 670         


Lys Val Thr Val Gln Met Glu Pro Ser Asp Ser Tyr Glu Val Leu Ser 
        675                 680                 685             


Cys Ile Pro Ala Pro Ser Leu Pro Tyr Asn Gln Pro Gly Ile Cys Tyr 
    690                 695                 700                 


Thr Leu Val Arg Leu Pro Asp Asp Asp Pro Thr Ala Gly Thr Asn Pro 
705                 710                 715                 720 


Gln Lys Gly Gly Asp Thr 
                725     


<210>  2455
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPRS__Homo_sapiens__NP_060875

<400>  2455

Met Asp Leu Gln Ala Ala Gly Ala Gln Ala Gln Gly Ala Ala Glu Pro 
1               5                   10                  15      


Ser Arg Gly Pro Pro Leu Pro Ser Ala Arg Gly Ala Pro Pro Ser Pro 
            20                  25                  30          


Glu Ala Gly Phe Ala Thr Ala Asp His Ser Ser Gln Glu Arg Glu Thr 
        35                  40                  45              


Glu Lys Ala Met Asp Arg Leu Ala Arg Gly Thr Gln Ser Ile Pro Asn 
    50                  55                  60                  


Asp Ser Pro Ala Arg Gly Glu Gly Thr His Ser Glu Glu Glu Gly Phe 
65                  70                  75                  80  


Ala Met Asp Glu Glu Asp Ser Asp Gly Glu Leu Asn Thr Trp Glu Leu 
                85                  90                  95      


Ser Glu Gly Thr Asn Cys Pro Pro Lys Glu Gln Pro Gly Asp Leu Phe 
            100                 105                 110         


Asn Glu Asp Trp Asp Ser Glu Leu Lys Ala Asp Gln Gly Asn Pro Tyr 
        115                 120                 125             


Asp Ala Asp Asp Ile Gln Glu Ser Ile Ser Gln Glu Leu Lys Pro Trp 
    130                 135                 140                 


Val Cys Cys Ala Pro Gln Gly Asp Met Ile Tyr Asp Pro Ser Trp His 
145                 150                 155                 160 


His Pro Pro Pro Leu Ile Pro Tyr Tyr Ser Lys Met Val Phe Glu Thr 
                165                 170                 175     


Gly Gln Phe Asp Asp Ala Glu Asp 
            180                 


<210>  2456
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPS2__Homo_sapiens__NP_001137359

<400>  2456

Met Ser Asp Met Glu Asp Asp Phe Met Cys Asp Asp Glu Glu Asp Tyr 
1               5                   10                  15      


Asp Leu Glu Tyr Ser Glu Asp Ser Asn Ser Glu Pro Asn Val Asp Leu 
            20                  25                  30          


Glu Asn Gln Tyr Tyr Asn Ser Lys Ala Leu Lys Glu Asp Asp Pro Lys 
        35                  40                  45              


Ala Ala Leu Ser Ser Phe Gln Lys Val Leu Glu Leu Glu Gly Glu Lys 
    50                  55                  60                  


Gly Glu Trp Gly Phe Lys Ala Leu Lys Gln Met Ile Lys Ile Asn Phe 
65                  70                  75                  80  


Lys Leu Thr Asn Phe Pro Glu Met Met Asn Arg Tyr Lys Gln Leu Leu 
                85                  90                  95      


Thr Tyr Ile Arg Ser Ala Val Thr Arg Asn Tyr Ser Glu Lys Ser Ile 
            100                 105                 110         


Asn Ser Ile Leu Asp Tyr Ile Ser Thr Ser Lys Gln Asn Ser Asp Phe 
        115                 120                 125             


Leu Cys Gln Met Asp Leu Leu Gln Glu Phe Tyr Glu Thr Thr Leu Glu 
    130                 135                 140                 


Ala Leu Lys Asp Ala Lys Asn Asp Arg Leu Trp Phe Lys Thr Asn Thr 
145                 150                 155                 160 


Lys Leu Gly Lys Leu Tyr Leu Glu Arg Glu Glu Tyr Gly Lys Leu Gln 
                165                 170                 175     


Lys Ile Leu Arg Gln Leu His Gln Ser Cys Gln Thr Asp Asp Gly Glu 
            180                 185                 190         


Asp Asp Leu Lys Lys Gly Thr Gln Leu Leu Glu Ile Tyr Ala Leu Glu 
        195                 200                 205             


Ile Gln Met Tyr Thr Ala Gln Lys Asn Asn Lys Lys Leu Lys Ala Leu 
    210                 215                 220                 


Tyr Glu Gln Ser Leu His Ile Lys Ser Ala Ile Pro His Pro Leu Ile 
225                 230                 235                 240 


Met Gly Val Ile Arg Glu Cys Gly Gly Lys Met His Leu Arg Glu Gly 
                245                 250                 255     


Glu Phe Glu Lys Ala His Thr Asp Phe Phe Glu Ala Phe Lys Asn Tyr 
            260                 265                 270         


Asp Glu Ser Gly Ser Pro Arg Arg Thr Thr Cys Leu Lys Tyr Leu Val 
        275                 280                 285             


Leu Ala Asn Met Leu Met Lys Ser Gly Ile Asn Pro Phe Asp Ser Gln 
    290                 295                 300                 


Glu Ala Lys Pro Tyr Lys Asn Asp Pro Glu Ile Leu Ala Met Thr Asn 
305                 310                 315                 320 


Leu Val Ser Ala Tyr Gln Asn Asn Asp Ile Thr Glu Phe Glu Lys Ile 
                325                 330                 335     


Leu Lys Thr Asn His Ser Asn Ile Met Asp Asp Pro Phe Ile Arg Glu 
            340                 345                 350         


His Ile Glu Glu Leu Leu Arg Asn Ile Arg Thr Gln Val Leu Ile Lys 
        355                 360                 365             


Leu Ile Lys Pro Tyr Thr Arg Ile His Ile Pro Phe Ile Ser Lys Glu 
    370                 375                 380                 


Leu Asn Ile Asp Val Ala Asp Val Glu Ser Leu Leu Val Gln Cys Ile 
385                 390                 395                 400 


Leu Asp Asn Thr Ile His Gly Arg Ile Asp Gln Val Asn Gln Leu Leu 
                405                 410                 415     


Glu Leu Asp His Gln Lys Arg Gly Gly Ala Arg Tyr Thr Ala Leu Asp 
            420                 425                 430         


Lys Trp Thr Asn Gln Leu Asn Ser Leu Asn Gln Ala Val Val Ser Lys 
        435                 440                 445             


Leu Ala 
    450 


<210>  2457
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPS3__Homo_sapiens__NP_001186054

<400>  2457

Met Thr Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly Glu Leu Leu Ala 
1               5                   10                  15      


Lys Asn Leu Ser His Leu Asp Thr Val Leu Gly Ala Leu Asp Val Gln 
            20                  25                  30          


Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val Lys Phe Ser Met 
        35                  40                  45              


Pro Ser Val Pro Asp Phe Glu Thr Leu Phe Ser Gln Val Gln Leu Phe 
    50                  55                  60                  


Ile Ser Thr Cys Asn Gly Glu His Ile Arg Tyr Ala Thr Asp Thr Phe 
65                  70                  75                  80  


Ala Gly Leu Cys His Gln Leu Thr Asn Ala Leu Val Glu Arg Lys Gln 
                85                  90                  95      


Pro Leu Arg Gly Ile Gly Ile Leu Lys Gln Ala Ile Asp Lys Met Gln 
            100                 105                 110         


Met Asn Thr Asn Gln Leu Thr Ser Ile His Ala Asp Leu Cys Gln Leu 
        115                 120                 125             


Cys Leu Leu Ala Lys Cys Phe Lys Pro Ala Leu Pro Tyr Leu Asp Val 
    130                 135                 140                 


Asp Met Met Asp Ile Cys Lys Glu Asn Gly Ala Tyr Asp Ala Lys His 
145                 150                 155                 160 


Phe Leu Cys Tyr Tyr Tyr Tyr Gly Gly Met Ile Tyr Thr Gly Leu Lys 
                165                 170                 175     


Asn Phe Glu Arg Ala Leu Tyr Phe Tyr Glu Gln Ala Ile Thr Thr Pro 
            180                 185                 190         


Ala Met Ala Val Ser His Ile Met Leu Glu Ser Tyr Lys Lys Tyr Ile 
        195                 200                 205             


Leu Val Ser Leu Ile Leu Leu Gly Lys Val Gln Gln Leu Pro Lys Tyr 
    210                 215                 220                 


Thr Ser Gln Ile Val Gly Arg Phe Ile Lys Pro Leu Ser Asn Ala Tyr 
225                 230                 235                 240 


His Glu Leu Ala Gln Val Tyr Ser Thr Asn Asn Pro Ser Glu Leu Arg 
                245                 250                 255     


Asn Leu Val Asn Lys His Ser Glu Thr Phe Thr Arg Asp Asn Asn Met 
            260                 265                 270         


Gly Leu Val Lys Gln Cys Leu Ser Ser Leu Tyr Lys Lys Asn Ile Gln 
        275                 280                 285             


Arg Leu Thr Lys Thr Phe Leu Thr Leu Ser Leu Gln Asp Met Ala Ser 
    290                 295                 300                 


Arg Val Gln Leu Ser Gly Pro Gln Glu Ala Glu Lys Tyr Val Leu His 
305                 310                 315                 320 


Met Ile Glu Asp Gly Glu Ile Phe Ala Ser Ile Asn Gln Lys Asp Gly 
                325                 330                 335     


Met Val Ser Phe His Asp Asn Pro Glu Lys Tyr Asn Asn Pro Ala Met 
            340                 345                 350         


Leu His Asn Ile Asp Gln Glu Met Leu Lys Cys Ile Glu Leu Asp Glu 
        355                 360                 365             


Arg Leu Lys Ala Met Asp Gln Glu Ile Thr Val Asn Pro Gln Phe Val 
    370                 375                 380                 


Gln Lys Ser Met Gly Ser Gln Glu Asp Asp Ser Gly Asn Lys Pro Ser 
385                 390                 395                 400 


Ser Tyr Ser 
            


<210>  2458
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPS4__Homo_sapiens__NP_001244935

<400>  2458

Met Ala Ala Ala Val Arg Gln Asp Leu Ala Gln Leu Met Asn Ser Ser 
1               5                   10                  15      


Gly Ser His Lys Asp Leu Ala Gly Lys Tyr Arg Gln Ile Leu Glu Lys 
            20                  25                  30          


Ala Ile Gln Leu Ser Gly Ala Glu Gln Leu Glu Ala Leu Lys Ala Phe 
        35                  40                  45              


Val Glu Ala Met Val Asn Glu Asn Val Ser Leu Val Ile Ser Arg Gln 
    50                  55                  60                  


Leu Leu Thr Asp Phe Cys Thr His Leu Pro Asn Leu Pro Asp Ser Thr 
65                  70                  75                  80  


Ala Lys Glu Ile Tyr His Phe Thr Leu Glu Lys Ile Gln Pro Arg Val 
                85                  90                  95      


Ile Ser Phe Glu Glu Gln Val Ala Ser Ile Arg Gln His Leu Ala Ser 
            100                 105                 110         


Ile Tyr Glu Lys Glu Glu Asp Trp Arg Asn Ala Ala Gln Val Leu Val 
        115                 120                 125             


Gly Ile Pro Leu Glu Thr Gly Gln Lys Gln Tyr Asn Val Asp Tyr Lys 
    130                 135                 140                 


Leu Glu Thr Tyr Leu Lys Ile Ala Arg Leu Tyr Leu Glu Asp Asp Asp 
145                 150                 155                 160 


Pro Val Gln Ala Glu Ala Tyr Ile Asn Arg Ala Ser Leu Leu Gln Asn 
                165                 170                 175     


Glu Ser Thr Asn Glu Gln Leu Gln Ile His Tyr Lys Val Cys Tyr Ala 
            180                 185                 190         


Arg Val Leu Asp Tyr Arg Arg Lys Phe Ile Glu Ala Ala Gln Arg Tyr 
        195                 200                 205             


Asn Glu Leu Ser Tyr Lys Thr Ile Val His Glu Ser Glu Arg Leu Glu 
    210                 215                 220                 


Ala Leu Lys His Ala Leu His Cys Thr Ile Leu Ala Ser Ala Gly Gln 
225                 230                 235                 240 


Gln Arg Ser Arg Met Leu Ala Thr Leu Phe Lys Asp Glu Arg Cys Gln 
                245                 250                 255     


Gln Leu Ala Ala Tyr Gly Ile Leu Glu Lys Met Tyr Leu Asp Arg Ile 
            260                 265                 270         


Ile Arg Gly Asn Gln Leu Gln Glu Phe Ala Ala Met Leu Met Pro His 
        275                 280                 285             


Gln Lys Ala Thr Thr Ala Asp Gly Ser Ser Ile Leu Asp Arg Ala Val 
    290                 295                 300                 


Ile Glu His Asn Leu Leu Ser Ala Ser Lys Leu Tyr Asn Asn Ile Thr 
305                 310                 315                 320 


Phe Glu Glu Leu Gly Ala Leu Leu Glu Ile Pro Ala Ala Lys His Glu 
                325                 330                 335     


Lys Pro Cys Gln Arg Gly Ile Ser Arg Ser Asn His Phe Val Ser Lys 
            340                 345                 350         


<210>  2459
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPS5__Homo_sapiens__NP_006828

<400>  2459

Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Thr Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Thr Lys Asp 
        35                  40                  45              


His His Tyr Phe Lys Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys 
    50                  55                  60                  


Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
65                  70                  75                  80  


Met Leu Gly Lys Val Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe 
                85                  90                  95      


Ala Leu Pro Val Glu Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala 
            100                 105                 110         


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
        115                 120                 125             


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
    130                 135                 140                 


Cys Trp Leu Ser Gly Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln 
145                 150                 155                 160 


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile 
                165                 170                 175     


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly 
            180                 185                 190         


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu 
        195                 200                 205             


Asn Lys Ile Glu Asp Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu 
    210                 215                 220                 


Glu Val Ser Tyr Phe Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu 
225                 230                 235                 240 


Leu Trp Asn Lys Tyr Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu 
                245                 250                 255     


Thr Asn Ala Asp Tyr Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys 
            260                 265                 270         


Leu Glu Gln Ser Glu Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly 
        275                 280                 285             


Leu Glu Thr His Asp Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr 
    290                 295                 300                 


Arg Asp Ser Cys Lys Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser 
305                 310                 315                 320 


Gln Val Ile Lys Asp Lys Leu Phe Asn Gln Ile Asn Ile Ser 
                325                 330                 


<210>  2460
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPS6__Homo_sapiens__NP_006824

<400>  2460

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210>  2461
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPS7A__Homo_sapiens__XP_005253752

<400>  2461

Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu 
1               5                   10                  15      


Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His 
            20                  25                  30          


Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp 
        35                  40                  45              


Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe 
    50                  55                  60                  


Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala 
65                  70                  75                  80  


Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu 
                85                  90                  95      


Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro 
            100                 105                 110         


Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu 
        115                 120                 125             


Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser 
    130                 135                 140                 


Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val 
            180                 185                 190         


Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln 
        195                 200                 205             


Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr 
225                 230                 235                 240 


Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys 
                245                 250                 255     


Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser 
            260                 265                 270         


Lys Ser Asn 
        275 


<210>  2462
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPS8__Homo_sapiens__NP_006701

<400>  2462

Met Pro Val Ala Val Met Ala Glu Ser Ala Phe Ser Phe Lys Lys Leu 
1               5                   10                  15      


Leu Asp Gln Cys Glu Asn Gln Glu Leu Glu Ala Pro Gly Gly Ile Ala 
            20                  25                  30          


Thr Pro Pro Val Tyr Gly Gln Leu Leu Ala Leu Tyr Leu Leu His Asn 
        35                  40                  45              


Asp Met Asn Asn Ala Arg Tyr Leu Trp Lys Arg Ile Pro Pro Ala Ile 
    50                  55                  60                  


Lys Ser Ala Asn Ser Glu Leu Gly Gly Ile Trp Ser Val Gly Gln Arg 
65                  70                  75                  80  


Ile Trp Gln Arg Asp Phe Pro Gly Ile Tyr Thr Thr Ile Asn Ala His 
                85                  90                  95      


Gln Trp Ser Glu Thr Val Gln Pro Ile Met Glu Ala Leu Arg Asp Ala 
            100                 105                 110         


Thr Arg Arg Arg Ala Phe Ala Leu Val Ser Gln Ala Tyr Thr Ser Ile 
        115                 120                 125             


Ile Ala Asp Asp Phe Ala Ala Phe Val Gly Leu Pro Val Glu Glu Ala 
    130                 135                 140                 


Val Lys Gly Ile Leu Glu Gln Gly Trp Gln Ala Asp Ser Thr Thr Arg 
145                 150                 155                 160 


Met Val Leu Pro Arg Lys Pro Val Ala Gly Ala Leu Asp Val Ser Phe 
                165                 170                 175     


Asn Lys Phe Ile Pro Leu Ser Glu Pro Ala Pro Val Pro Pro Ile Pro 
            180                 185                 190         


Asn Glu Gln Gln Leu Ala Arg Leu Thr Asp Tyr Val Ala Phe Leu Glu 
        195                 200                 205             


Asn 
    


<210>  2463
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COPZ2__Homo_sapiens__NP_057513

<400>  2463

Met Gln Arg Pro Glu Ala Trp Pro Arg Pro His Pro Gly Glu Gly Ala 
1               5                   10                  15      


Ala Ala Ala Gln Ala Gly Gly Pro Ala Pro Pro Ala Arg Ala Gly Glu 
            20                  25                  30          


Pro Ser Gly Leu Arg Leu Gln Glu Pro Ser Leu Tyr Thr Ile Lys Ala 
        35                  40                  45              


Val Phe Ile Leu Asp Asn Asp Gly Arg Arg Leu Leu Ala Lys Tyr Tyr 
    50                  55                  60                  


Asp Asp Thr Phe Pro Ser Met Lys Glu Gln Met Val Phe Glu Lys Asn 
65                  70                  75                  80  


Val Phe Asn Lys Thr Ser Arg Thr Glu Ser Glu Ile Ala Phe Phe Gly 
                85                  90                  95      


Gly Met Thr Ile Val Tyr Lys Asn Ser Ile Asp Leu Phe Leu Tyr Val 
            100                 105                 110         


Val Gly Ser Ser Tyr Glu Asn Glu Leu Met Leu Met Ser Val Leu Thr 
        115                 120                 125             


Cys Leu Phe Glu Ser Leu Asn His Met Leu Arg Lys Asn Val Glu Lys 
    130                 135                 140                 


Arg Trp Leu Leu Glu Asn Met Asp Gly Ala Phe Leu Val Leu Asp Glu 
145                 150                 155                 160 


Ile Val Asp Gly Gly Val Ile Leu Glu Ser Asp Pro Gln Gln Val Ile 
                165                 170                 175     


Gln Lys Val Asn Phe Arg Ala Asp Asp Gly Gly Leu Thr Glu Gln Ser 
            180                 185                 190         


Val Ala Gln Val Leu Gln Ser Ala Lys Glu Gln Ile Lys Trp Ser Leu 
        195                 200                 205             


Leu Lys 
    210 


<210>  2464
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COQ2__Homo_sapiens__NP_056512

<400>  2464

Met Thr Pro Ile Ser Gln Val Arg Met Arg Lys Gly Ser Ala His Thr 
1               5                   10                  15      


Ala Ala Gln Pro Gly Arg Leu Gly Leu His Pro Ala Gly Ala Thr Ala 
            20                  25                  30          


His Ala Cys Arg Gly Met Thr Ser Ile Arg Ala Arg Pro Gly Leu Thr 
        35                  40                  45              


Ser Ala Met Leu Gly Ser Arg Ala Ala Gly Phe Ala Arg Gly Leu Arg 
    50                  55                  60                  


Ala Val Ala Leu Ala Trp Leu Pro Gly Trp Arg Gly Arg Ser Phe Ala 
65                  70                  75                  80  


Leu Ala Arg Ala Ala Gly Ala Pro His Gly Gly Asp Leu Gln Pro Pro 
                85                  90                  95      


Ala Cys Pro Glu Pro Arg Gly Arg Gln Leu Ser Leu Ser Ala Ala Ala 
            100                 105                 110         


Val Val Asp Ser Ala Pro Arg Pro Leu Gln Pro Tyr Leu Arg Leu Met 
        115                 120                 125             


Arg Leu Asp Lys Pro Ile Gly Thr Trp Leu Leu Tyr Leu Pro Cys Thr 
    130                 135                 140                 


Trp Ser Ile Gly Leu Ala Ala Glu Pro Gly Cys Phe Pro Asp Trp Tyr 
145                 150                 155                 160 


Met Leu Ser Leu Phe Gly Thr Gly Ala Ile Leu Met Arg Gly Ala Gly 
                165                 170                 175     


Cys Thr Ile Asn Asp Met Trp Asp Gln Asp Tyr Asp Lys Lys Val Thr 
            180                 185                 190         


Arg Thr Ala Asn Arg Pro Ile Ala Ala Gly Asp Ile Ser Thr Phe Gln 
        195                 200                 205             


Ser Phe Val Phe Leu Gly Gly Gln Leu Thr Leu Ala Leu Gly Val Leu 
    210                 215                 220                 


Leu Cys Leu Asn Tyr Tyr Ser Ile Ala Leu Gly Ala Gly Ser Leu Leu 
225                 230                 235                 240 


Leu Val Ile Thr Tyr Pro Leu Met Lys Arg Ile Ser Tyr Trp Pro Gln 
                245                 250                 255     


Leu Ala Leu Gly Leu Thr Phe Asn Trp Gly Ala Leu Leu Gly Trp Ser 
            260                 265                 270         


Ala Ile Lys Gly Ser Cys Asp Pro Ser Val Cys Leu Pro Leu Tyr Phe 
        275                 280                 285             


Ser Gly Val Met Trp Thr Leu Ile Tyr Asp Thr Ile Tyr Ala His Gln 
    290                 295                 300                 


Asp Lys Arg Asp Asp Val Leu Ile Gly Leu Lys Ser Thr Ala Leu Arg 
305                 310                 315                 320 


Phe Gly Glu Asn Thr Lys Pro Trp Leu Ser Gly Phe Ser Val Ala Met 
                325                 330                 335     


Leu Gly Ala Leu Ser Leu Val Gly Val Asn Ser Gly Gln Thr Ala Pro 
            340                 345                 350         


Tyr Tyr Ala Ala Leu Gly Ala Val Gly Ala His Leu Thr His Gln Ile 
        355                 360                 365             


Tyr Thr Leu Asp Ile His Arg Pro Glu Asp Cys Trp Asn Lys Phe Ile 
    370                 375                 380                 


Ser Asn Arg Thr Leu Gly Leu Ile Val Phe Leu Gly Ile Val Leu Gly 
385                 390                 395                 400 


Asn Leu Trp Lys Glu Lys Lys Thr Asp Lys Thr Lys Lys Gly Ile Glu 
                405                 410                 415     


Asn Lys Ile Glu Asn 
            420     


<210>  2465
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COQ3__Homo_sapiens__NP_059117

<400>  2465

Met Trp Ser Gly Arg Lys Leu Gly Ser Ser Gly Gly Trp Phe Leu Arg 
1               5                   10                  15      


Val Leu Gly Pro Gly Gly Cys Asn Thr Lys Ala Ala Arg Pro Leu Ile 
            20                  25                  30          


Ser Ser Ala Val Tyr Val Lys Asn Gln Leu Ser Gly Thr Leu Gln Ile 
        35                  40                  45              


Lys Pro Gly Val Phe Asn Glu Tyr Arg Thr Ile Trp Phe Lys Ser Tyr 
    50                  55                  60                  


Arg Thr Ile Phe Ser Cys Leu Asn Arg Ile Lys Ser Phe Arg Tyr Pro 
65                  70                  75                  80  


Trp Ala Arg Leu Tyr Ser Thr Ser Gln Thr Thr Val Asp Ser Gly Glu 
                85                  90                  95      


Val Lys Thr Phe Leu Ala Leu Ala His Lys Trp Trp Asp Glu Gln Gly 
            100                 105                 110         


Val Tyr Ala Pro Leu His Ser Met Asn Asp Leu Arg Val Pro Phe Ile 
        115                 120                 125             


Arg Asp Asn Leu Leu Lys Thr Ile Pro Asn His Gln Pro Gly Lys Pro 
    130                 135                 140                 


Leu Leu Gly Met Lys Ile Leu Asp Val Gly Cys Gly Gly Gly Leu Leu 
145                 150                 155                 160 


Thr Glu Pro Leu Gly Arg Leu Gly Ala Ser Val Ile Gly Ile Asp Pro 
                165                 170                 175     


Val Asp Glu Asn Ile Lys Thr Ala Gln Cys His Lys Ser Phe Asp Pro 
            180                 185                 190         


Val Leu Asp Lys Arg Ile Glu Tyr Arg Val Cys Ser Leu Glu Glu Ile 
        195                 200                 205             


Val Glu Glu Thr Ala Glu Thr Phe Asp Ala Val Val Ala Ser Glu Val 
    210                 215                 220                 


Val Glu His Val Ile Asp Leu Glu Thr Phe Leu Gln Cys Cys Cys Gln 
225                 230                 235                 240 


Val Leu Lys Pro Gly Gly Ser Leu Phe Ile Thr Thr Ile Asn Lys Thr 
                245                 250                 255     


Gln Leu Ser Tyr Ala Leu Gly Ile Val Phe Ser Glu Gln Ile Ala Ser 
            260                 265                 270         


Ile Val Pro Lys Gly Thr His Thr Trp Glu Lys Phe Val Ser Pro Glu 
        275                 280                 285             


Thr Leu Glu Ser Ile Leu Glu Ser Asn Gly Leu Ser Val Gln Thr Val 
    290                 295                 300                 


Val Gly Met Leu Tyr Asn Pro Phe Ser Gly Tyr Trp His Trp Ser Glu 
305                 310                 315                 320 


Asn Thr Ser Leu Asn Tyr Ala Ala Tyr Ala Val Lys Ser Arg Val Gln 
                325                 330                 335     


Glu His Pro Ala Ser Ala Glu Phe Val Leu Lys Gly Glu Thr Glu Glu 
            340                 345                 350         


Leu Gln Ala Asn Ala Cys Thr Asn Pro Ala Val His Glu Lys Leu Lys 
        355                 360                 365             


Lys 
    


<210>  2466
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COQ4__Homo_sapiens__NP_057119

<400>  2466

Met Ala Thr Leu Leu Arg Pro Val Leu Arg Arg Leu Cys Gly Leu Pro 
1               5                   10                  15      


Gly Leu Gln Arg Pro Ala Ala Glu Met Pro Leu Arg Ala Arg Ser Asp 
            20                  25                  30          


Gly Ala Gly Pro Leu Tyr Ser His His Leu Pro Thr Ser Pro Leu Gln 
        35                  40                  45              


Lys Ala Leu Leu Ala Ala Gly Ser Ala Ala Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Tyr Arg His Asp Met Val Ala Val Leu Gly Glu Thr Thr Gly His Arg 
65                  70                  75                  80  


Thr Leu Lys Val Leu Arg Asp Gln Met Arg Arg Asp Pro Glu Gly Ala 
                85                  90                  95      


Gln Ile Leu Gln Glu Arg Pro Arg Ile Ser Thr Ser Thr Leu Asp Leu 
            100                 105                 110         


Gly Lys Leu Gln Ser Leu Pro Glu Gly Ser Leu Gly Arg Glu Tyr Leu 
        115                 120                 125             


Arg Phe Leu Asp Val Asn Arg Val Ser Pro Asp Thr Arg Ala Pro Thr 
    130                 135                 140                 


Arg Phe Val Asp Asp Glu Glu Leu Ala Tyr Val Ile Gln Arg Tyr Arg 
145                 150                 155                 160 


Glu Val His Asp Met Leu His Thr Leu Leu Gly Met Pro Thr Asn Ile 
                165                 170                 175     


Leu Gly Glu Ile Val Val Lys Trp Phe Glu Ala Val Gln Thr Gly Leu 
            180                 185                 190         


Pro Met Cys Ile Leu Gly Ala Phe Phe Gly Pro Ile Arg Leu Gly Ala 
        195                 200                 205             


Gln Ser Leu Gln Val Leu Val Ser Glu Leu Ile Pro Trp Ala Val Gln 
    210                 215                 220                 


Asn Gly Arg Arg Ala Pro Cys Val Leu Asn Leu Tyr Tyr Glu Arg Arg 
225                 230                 235                 240 


Trp Glu Gln Ser Leu Arg Ala Leu Arg Glu Glu Leu Gly Ile Thr Ala 
                245                 250                 255     


Pro Pro Met His Val Gln Gly Leu Ala 
            260                 265 


<210>  2467
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COQ5__Homo_sapiens__NP_115690

<400>  2467

Met Ala Ala Pro Gly Ser Cys Ala Leu Trp Ser Tyr Cys Gly Arg Gly 
1               5                   10                  15      


Trp Ser Arg Ala Met Arg Gly Cys Gln Leu Leu Gly Leu Arg Ser Ser 
            20                  25                  30          


Trp Pro Gly Asp Leu Leu Ser Ala Arg Leu Leu Ser Gln Glu Lys Arg 
        35                  40                  45              


Ala Ala Glu Thr His Phe Gly Phe Glu Thr Val Ser Glu Glu Glu Lys 
    50                  55                  60                  


Gly Gly Lys Val Tyr Gln Val Phe Glu Ser Val Ala Lys Lys Tyr Asp 
65                  70                  75                  80  


Val Met Asn Asp Met Met Ser Leu Gly Ile His Arg Val Trp Lys Asp 
                85                  90                  95      


Leu Leu Leu Trp Lys Met His Pro Leu Pro Gly Thr Gln Leu Leu Asp 
            100                 105                 110         


Val Ala Gly Gly Thr Gly Asp Ile Ala Phe Arg Phe Leu Asn Tyr Val 
        115                 120                 125             


Gln Ser Gln His Gln Arg Lys Gln Lys Arg Gln Leu Arg Ala Gln Gln 
    130                 135                 140                 


Asn Leu Ser Trp Glu Glu Ile Ala Lys Glu Tyr Gln Asn Glu Glu Asp 
145                 150                 155                 160 


Ser Leu Gly Gly Ser Arg Val Val Val Cys Asp Ile Asn Lys Glu Met 
                165                 170                 175     


Leu Lys Val Gly Lys Gln Lys Ala Leu Ala Gln Gly Tyr Arg Ala Gly 
            180                 185                 190         


Leu Ala Trp Val Leu Gly Asp Ala Glu Glu Leu Pro Phe Asp Asp Asp 
        195                 200                 205             


Lys Phe Asp Ile Tyr Thr Ile Ala Phe Gly Ile Arg Asn Val Thr His 
    210                 215                 220                 


Ile Asp Gln Ala Leu Gln Glu Ala His Arg Val Leu Lys Pro Gly Gly 
225                 230                 235                 240 


Arg Phe Leu Cys Leu Glu Phe Ser Gln Val Asn Asn Pro Leu Ile Ser 
                245                 250                 255     


Arg Leu Tyr Asp Leu Tyr Ser Phe Gln Val Ile Pro Val Leu Gly Glu 
            260                 265                 270         


Val Ile Ala Gly Asp Trp Lys Ser Tyr Gln Tyr Leu Val Glu Ser Ile 
        275                 280                 285             


Arg Arg Phe Pro Ser Gln Glu Glu Phe Lys Asp Met Ile Glu Asp Ala 
    290                 295                 300                 


Gly Phe His Lys Val Thr Tyr Glu Ser Leu Thr Ser Gly Ile Val Ala 
305                 310                 315                 320 


Ile His Ser Gly Phe Lys Leu 
                325         


<210>  2468
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COQ6__Homo_sapiens__NP_872282

<400>  2468

Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro 
1               5                   10                  15      


His Ser Gly Pro Leu Val Ser Trp Arg Arg Trp Ser Gly Ala Ser Thr 
            20                  25                  30          


Asp Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala 
        35                  40                  45              


Ala Met Ala Cys Ala Leu Gly Tyr Asp Ile His Phe His Asp Lys Lys 
    50                  55                  60                  


Ile Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser 
65                  70                  75                  80  


Glu Thr Tyr Ser Asn Arg Val Ser Ser Ile Ser Pro Gly Ser Ala Thr 
                85                  90                  95      


Leu Leu Ser Ser Phe Gly Ala Trp Asp His Ile Cys Asn Met Arg Tyr 
            100                 105                 110         


Arg Ala Phe Arg Arg Met Gln Val Trp Asp Ala Cys Ser Glu Ala Leu 
        115                 120                 125             


Ile Met Phe Asp Lys Asp Asn Leu Asp Asp Met Gly Tyr Ile Val Glu 
    130                 135                 140                 


Asn Asp Val Ile Met His Ala Leu Thr Lys Gln Leu Glu Ala Val Ser 
145                 150                 155                 160 


Asp Arg Val Thr Val Leu Tyr Arg Ser Lys Ala Ile Arg Tyr Thr Trp 
                165                 170                 175     


Pro Cys Pro Phe Pro Met Ala Asp Ser Ser Pro Trp Val His Ile Thr 
            180                 185                 190         


Leu Gly Asp Gly Ser Thr Phe Gln Thr Lys Leu Leu Ile Gly Ala Asp 
        195                 200                 205             


Gly His Asn Ser Gly Val Arg Gln Ala Val Gly Ile Gln Asn Val Ser 
    210                 215                 220                 


Trp Asn Tyr Asp Gln Ser Ala Val Val Ala Thr Leu His Leu Ser Glu 
225                 230                 235                 240 


Ala Thr Glu Asn Asn Val Ala Trp Gln Arg Phe Leu Pro Ser Gly Pro 
                245                 250                 255     


Ile Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser Ser Leu Val Trp Ser 
            260                 265                 270         


Thr Ser His Glu His Ala Ala Glu Leu Val Ser Met Asp Glu Glu Lys 
        275                 280                 285             


Phe Val Asp Ala Val Asn Ser Ala Phe Trp Ser Asp Ala Asp His Thr 
    290                 295                 300                 


Asp Phe Ile Asp Thr Ala Gly Ala Met Leu Gln Tyr Ala Val Ser Leu 
305                 310                 315                 320 


Leu Lys Pro Thr Lys Val Ser Ala Arg Gln Leu Pro Pro Ser Val Ala 
                325                 330                 335     


Arg Val Asp Ala Lys Ser Arg Val Leu Phe Pro Leu Gly Leu Gly His 
            340                 345                 350         


Ala Ala Glu Tyr Val Arg Pro Arg Val Ala Leu Ile Gly Asp Ala Ala 
        355                 360                 365             


His Arg Val His Pro Leu Ala Gly Gln Gly Val Asn Met Gly Phe Gly 
    370                 375                 380                 


Asp Ile Ser Ser Leu Ala His His Leu Ser Thr Ala Ala Phe Asn Gly 
385                 390                 395                 400 


Lys Asp Leu Gly Ser Val Ser His Leu Thr Gly Tyr Glu Thr Glu Arg 
                405                 410                 415     


Gln Arg His Asn Thr Ala Leu Leu Ala Ala Thr Asp Leu Leu Lys Arg 
            420                 425                 430         


Leu Tyr Ser Thr Ser Ala Ser Pro Leu Val Leu Leu Arg Thr Trp Gly 
        435                 440                 445             


Leu Gln Ala Thr Asn Ala Val Ser Pro Leu Lys Glu Gln Ile Met Ala 
    450                 455                 460                 


Phe Ala Ser Lys 
465             


<210>  2469
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COQ7__Homo_sapiens__NP_001177912

<400>  2469

Met Thr Leu Asp Asn Ile Ser Arg Ala Ala Val Asp Arg Ile Ile Arg 
1               5                   10                  15      


Val Asp His Ala Gly Glu Tyr Gly Ala Asn Arg Ile Tyr Ala Gly Gln 
            20                  25                  30          


Met Ala Val Leu Gly Arg Thr Ser Val Gly Pro Val Ile Gln Lys Met 
        35                  40                  45              


Trp Asp Gln Glu Lys Asp His Leu Lys Lys Phe Asn Glu Leu Met Val 
    50                  55                  60                  


Thr Phe Arg Val Arg Pro Thr Val Leu Met Pro Leu Trp Asn Val Leu 
65                  70                  75                  80  


Gly Phe Ala Leu Gly Ala Gly Thr Ala Leu Leu Gly Lys Glu Gly Ala 
                85                  90                  95      


Met Ala Cys Thr Val Ala Val Glu Glu Ser Ile Ala His His Tyr Asn 
            100                 105                 110         


Asn Gln Ile Arg Thr Leu Met Glu Glu Asp Pro Glu Lys Tyr Glu Glu 
        115                 120                 125             


Leu Leu Gln Leu Ile Lys Lys Phe Arg Asp Glu Glu Leu Glu His His 
    130                 135                 140                 


Asp Ile Gly Leu Asp His Asp Ala Glu Leu Ala Pro Ala Tyr Ala Val 
145                 150                 155                 160 


Leu Lys Ser Ile Ile Gln Ala Gly Cys Arg Val Ala Ile Tyr Leu Ser 
                165                 170                 175     


Glu Arg Leu 
            


<210>  2470
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COQ9__Homo_sapiens__NP_064708

<400>  2470

Met Ala Ala Ala Ala Val Ser Gly Ala Leu Gly Arg Ala Gly Trp Arg 
1               5                   10                  15      


Leu Leu Gln Leu Arg Cys Leu Pro Val Ala Arg Cys Arg Gln Ala Leu 
            20                  25                  30          


Val Pro Arg Ala Phe His Ala Ser Ala Val Gly Leu Arg Ser Ser Asp 
        35                  40                  45              


Glu Gln Lys Gln Gln Pro Pro Asn Ser Phe Ser Gln Gln His Ser Glu 
    50                  55                  60                  


Thr Gln Gly Ala Glu Lys Pro Asp Pro Glu Ser Ser His Ser Pro Pro 
65                  70                  75                  80  


Arg Tyr Thr Asp Gln Gly Gly Glu Glu Glu Glu Asp Tyr Glu Ser Glu 
                85                  90                  95      


Glu Gln Leu Gln His Arg Ile Leu Thr Ala Ala Leu Glu Phe Val Pro 
            100                 105                 110         


Ala His Gly Trp Thr Ala Glu Ala Ile Ala Glu Gly Ala Gln Ser Leu 
        115                 120                 125             


Gly Leu Ser Ser Ala Ala Ala Ser Met Phe Gly Lys Asp Gly Ser Glu 
    130                 135                 140                 


Leu Ile Leu His Phe Val Thr Gln Cys Asn Thr Arg Leu Thr Arg Val 
145                 150                 155                 160 


Leu Glu Glu Glu Gln Lys Leu Val Gln Leu Gly Gln Ala Glu Lys Arg 
                165                 170                 175     


Lys Thr Asp Gln Phe Leu Arg Asp Ala Val Glu Thr Arg Leu Arg Met 
            180                 185                 190         


Leu Ile Pro Tyr Ile Glu His Trp Pro Arg Ala Leu Ser Ile Leu Met 
        195                 200                 205             


Leu Pro His Asn Ile Pro Ser Ser Leu Ser Leu Leu Thr Ser Met Val 
    210                 215                 220                 


Asp Asp Met Trp His Tyr Ala Gly Asp Gln Ser Thr Asp Phe Asn Trp 
225                 230                 235                 240 


Tyr Thr Arg Arg Ala Met Leu Ala Ala Ile Tyr Asn Thr Thr Glu Leu 
                245                 250                 255     


Val Met Met Gln Asp Ser Ser Pro Asp Phe Glu Asp Thr Trp Arg Phe 
            260                 265                 270         


Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met Gly His Thr Ala Lys 
        275                 280                 285             


Gln Val Lys Ser Thr Gly Glu Ala Leu Val Gln Gly Leu Met Gly Ala 
    290                 295                 300                 


Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn Gln Arg Arg 
305                 310                 315             


<210>  2471
<211>  1042
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORIN__Homo_sapiens__NP_006578

<400>  2471

Met Lys Gln Ser Pro Ala Leu Ala Pro Glu Glu Arg Cys Arg Arg Ala 
1               5                   10                  15      


Gly Ser Pro Lys Pro Val Leu Arg Ala Asp Asp Asn Asn Met Gly Asn 
            20                  25                  30          


Gly Cys Ser Gln Lys Leu Ala Thr Ala Asn Leu Leu Arg Phe Leu Leu 
        35                  40                  45              


Leu Val Leu Ile Pro Cys Ile Cys Ala Leu Val Leu Leu Leu Val Ile 
    50                  55                  60                  


Leu Leu Ser Tyr Val Gly Thr Leu Gln Lys Val Tyr Phe Lys Ser Asn 
65                  70                  75                  80  


Gly Ser Glu Pro Leu Val Thr Asp Gly Glu Ile Gln Gly Ser Asp Val 
                85                  90                  95      


Ile Leu Thr Asn Thr Ile Tyr Asn Gln Ser Thr Val Val Ser Thr Ala 
            100                 105                 110         


His Pro Asp Gln His Val Pro Ala Trp Thr Thr Asp Ala Ser Leu Pro 
        115                 120                 125             


Gly Asp Gln Ser His Arg Asn Thr Ser Ala Cys Met Asn Ile Thr His 
    130                 135                 140                 


Ser Gln Cys Gln Met Leu Pro Tyr His Ala Thr Leu Thr Pro Leu Leu 
145                 150                 155                 160 


Ser Val Val Arg Asn Met Glu Met Glu Lys Phe Leu Lys Phe Phe Thr 
                165                 170                 175     


Tyr Leu His Arg Leu Ser Cys Tyr Gln His Ile Met Leu Phe Gly Cys 
            180                 185                 190         


Thr Leu Ala Phe Pro Glu Cys Ile Ile Asp Gly Asp Asp Ser His Gly 
        195                 200                 205             


Leu Leu Pro Cys Arg Ser Phe Cys Glu Ala Ala Lys Glu Gly Cys Glu 
    210                 215                 220                 


Ser Val Leu Gly Met Val Asn Tyr Ser Trp Pro Asp Phe Leu Arg Cys 
225                 230                 235                 240 


Ser Gln Phe Arg Asn Gln Thr Glu Ser Ser Asn Val Ser Arg Ile Cys 
                245                 250                 255     


Phe Ser Pro Gln Gln Glu Asn Gly Lys Gln Leu Leu Cys Gly Arg Gly 
            260                 265                 270         


Glu Asn Phe Leu Cys Ala Ser Gly Ile Cys Ile Pro Gly Lys Leu Gln 
        275                 280                 285             


Cys Asn Gly Tyr Asn Asp Cys Asp Asp Trp Ser Asp Glu Ala His Cys 
    290                 295                 300                 


Asn Cys Ser Glu Asn Leu Phe His Cys His Thr Gly Lys Cys Leu Asn 
305                 310                 315                 320 


Tyr Ser Leu Val Cys Asp Gly Tyr Asp Asp Cys Gly Asp Leu Ser Asp 
                325                 330                 335     


Glu Gln Asn Cys Asp Cys Asn Pro Thr Thr Glu His Arg Cys Gly Asp 
            340                 345                 350         


Gly Arg Cys Ile Ala Met Glu Trp Val Cys Asp Gly Asp His Asp Cys 
        355                 360                 365             


Val Asp Lys Ser Asp Glu Val Asn Cys Ser Cys His Ser Gln Gly Leu 
    370                 375                 380                 


Val Glu Cys Arg Asn Gly Gln Cys Ile Pro Ser Thr Phe Gln Cys Asp 
385                 390                 395                 400 


Gly Asp Glu Asp Cys Lys Asp Gly Ser Asp Glu Glu Asn Cys Ser Val 
                405                 410                 415     


Ile Gln Thr Ser Cys Gln Glu Gly Asp Gln Arg Cys Leu Tyr Asn Pro 
            420                 425                 430         


Cys Leu Asp Ser Cys Gly Gly Ser Ser Leu Cys Asp Pro Asn Asn Ser 
        435                 440                 445             


Leu Asn Asn Cys Ser Gln Cys Glu Pro Ile Thr Leu Glu Leu Cys Met 
    450                 455                 460                 


Asn Leu Pro Tyr Asn Ser Thr Ser Tyr Pro Asn Tyr Phe Gly His Arg 
465                 470                 475                 480 


Thr Gln Lys Glu Ala Ser Ile Ser Trp Glu Ser Ser Leu Phe Pro Ala 
                485                 490                 495     


Leu Val Gln Thr Asn Cys Tyr Lys Tyr Leu Met Phe Phe Ser Cys Thr 
            500                 505                 510         


Ile Leu Val Pro Lys Cys Asp Val Asn Thr Gly Glu His Ile Pro Pro 
        515                 520                 525             


Cys Arg Ala Leu Cys Glu His Ser Lys Glu Arg Cys Glu Ser Val Leu 
    530                 535                 540                 


Gly Ile Val Gly Leu Gln Trp Pro Glu Asp Thr Asp Cys Ser Gln Phe 
545                 550                 555                 560 


Pro Glu Glu Asn Ser Asp Asn Gln Thr Cys Leu Met Pro Asp Glu Tyr 
                565                 570                 575     


Val Glu Glu Cys Ser Pro Ser His Phe Lys Cys Arg Ser Gly Gln Cys 
            580                 585                 590         


Val Leu Ala Ser Arg Arg Cys Asp Gly Gln Ala Asp Cys Asp Asp Asp 
        595                 600                 605             


Ser Asp Glu Glu Asn Cys Gly Cys Lys Glu Arg Asp Leu Trp Glu Cys 
    610                 615                 620                 


Pro Ser Asn Lys Gln Cys Leu Lys His Thr Val Ile Cys Asp Gly Phe 
625                 630                 635                 640 


Pro Asp Cys Pro Asp Tyr Met Asp Glu Lys Asn Cys Ser Phe Cys Gln 
                645                 650                 655     


Asp Asp Glu Leu Glu Cys Ala Asn His Ala Cys Val Ser Arg Asp Leu 
            660                 665                 670         


Trp Cys Asp Gly Glu Ala Asp Cys Ser Asp Ser Ser Asp Glu Trp Asp 
        675                 680                 685             


Cys Val Thr Leu Ser Ile Asn Val Asn Ser Ser Ser Phe Leu Met Val 
    690                 695                 700                 


His Arg Ala Ala Thr Glu His His Val Cys Ala Asp Gly Trp Gln Glu 
705                 710                 715                 720 


Ile Leu Ser Gln Leu Ala Cys Lys Gln Met Gly Leu Gly Glu Pro Ser 
                725                 730                 735     


Val Thr Lys Leu Ile Gln Glu Gln Glu Lys Glu Pro Arg Trp Leu Thr 
            740                 745                 750         


Leu His Ser Asn Trp Glu Ser Leu Asn Gly Thr Thr Leu His Glu Leu 
        755                 760                 765             


Leu Val Asn Gly Gln Ser Cys Glu Ser Arg Ser Lys Ile Ser Leu Leu 
    770                 775                 780                 


Cys Thr Lys Gln Asp Cys Gly Arg Arg Pro Ala Ala Arg Met Asn Lys 
785                 790                 795                 800 


Arg Ile Leu Gly Gly Arg Thr Ser Arg Pro Gly Arg Trp Pro Trp Gln 
                805                 810                 815     


Cys Ser Leu Gln Ser Glu Pro Ser Gly His Ile Cys Gly Cys Val Leu 
            820                 825                 830         


Ile Ala Lys Lys Trp Val Leu Thr Val Ala His Cys Phe Glu Gly Arg 
        835                 840                 845             


Glu Asn Ala Ala Val Trp Lys Val Val Leu Gly Ile Asn Asn Leu Asp 
    850                 855                 860                 


His Pro Ser Val Phe Met Gln Thr Arg Phe Val Lys Thr Ile Ile Leu 
865                 870                 875                 880 


His Pro Arg Tyr Ser Arg Ala Val Val Asp Tyr Asp Ile Ser Ile Val 
                885                 890                 895     


Glu Leu Ser Glu Asp Ile Ser Glu Thr Gly Tyr Val Arg Pro Val Cys 
            900                 905                 910         


Leu Pro Asn Pro Glu Gln Trp Leu Glu Pro Asp Thr Tyr Cys Tyr Ile 
        915                 920                 925             


Thr Gly Trp Gly His Met Gly Asn Lys Met Pro Phe Lys Leu Gln Glu 
    930                 935                 940                 


Gly Glu Val Arg Ile Ile Ser Leu Glu His Cys Gln Ser Tyr Phe Asp 
945                 950                 955                 960 


Met Lys Thr Ile Thr Thr Arg Met Ile Cys Ala Gly Tyr Glu Ser Gly 
                965                 970                 975     


Thr Val Asp Ser Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Glu 
            980                 985                 990         


Lys Pro Gly Gly Arg Trp Thr Leu  Phe Gly Leu Thr Ser  Trp Gly Ser 
        995                 1000                 1005             


Val Cys  Phe Ser Lys Val Leu  Gly Pro Gly Val Tyr  Ser Asn Val 
    1010                 1015                 1020             


Ser Tyr  Phe Val Glu Trp Ile  Lys Arg Gln Ile Tyr  Ile Gln Thr 
    1025                 1030                 1035             


Phe Leu  Leu Asn 
    1040         


<210>  2472
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO1A__Homo_sapiens__XP_011544016

<400>  2472

Met Ser Arg Gln Val Val Arg Ser Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Pro Ala Lys Ala Asp Gln Cys Tyr Glu Asp Val Arg Val Ser Gln 
            20                  25                  30          


Thr Thr Trp Asp Ser Gly Phe Cys Ala Val Asn Pro Lys Phe Val Ala 
        35                  40                  45              


Leu Ile Cys Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro Leu 
    50                  55                  60                  


Gly Lys Thr Gly Arg Val Asp Lys Asn Ala Pro Thr Val Cys Gly His 
65                  70                  75                  80  


Thr Ala Pro Val Leu Asp Ile Ala Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Glu Ile Pro 
            100                 105                 110         


Asp Gly Gly Leu Met Leu Pro Leu Arg Glu Pro Val Val Thr Leu Glu 
        115                 120                 125             


Gly His Thr Lys Arg Val Gly Ile Val Ala Trp His Thr Thr Ala Gln 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Ile Met Val Trp Asp 
145                 150                 155                 160 


Val Gly Thr Gly Ala Ala Met Leu Thr Leu Gly Pro Glu Val His Pro 
                165                 170                 175     


Asp Thr Ile Tyr Ser Val Asp Trp Ser Arg Asp Gly Gly Leu Ile Cys 
            180                 185                 190         


Thr Ser Cys Arg Asp Lys Arg Val Arg Ile Ile Glu Pro Arg Lys Gly 
        195                 200                 205             


Thr Val Val Ala Glu Lys Asp Arg Pro His Glu Gly Thr Arg Pro Val 
    210                 215                 220                 


Arg Ala Val Phe Val Ser Glu Gly Lys Ile Leu Thr Thr Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Val Ala Leu Trp Asp Thr Lys His Leu Glu 
                245                 250                 255     


Glu Pro Leu Ser Leu Gln Glu Leu Asp Thr Ser Ser Gly Val Leu Leu 
            260                 265                 270         


Pro Phe Phe Asp Pro Asp Thr Asn Ile Val Tyr Leu Cys Gly Lys Gly 
        275                 280                 285             


Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Ser Glu Ala Pro Phe Leu 
    290                 295                 300                 


His Tyr Leu Ser Met Phe Ser Ser Lys Glu Ser Gln Arg Gly Met Gly 
305                 310                 315                 320 


Tyr Met Pro Lys Arg Gly Leu Glu Val Asn Lys Cys Glu Ile Ala Arg 
                325                 330                 335     


Phe Tyr Lys Leu His Glu Arg Arg Cys Glu Pro Ile Ala Met Thr Val 
            340                 345                 350         


Pro Arg Lys Ser Asp Leu Phe Gln Glu Asp Leu Tyr Pro Pro Thr Ala 
        355                 360                 365             


Gly Pro Asp Pro Ala Leu Thr Ala Glu Glu Trp Leu Gly Gly Arg Asp 
    370                 375                 380                 


Ala Gly Pro Leu Leu Ile Ser Leu Lys Asp Gly Tyr Val Pro Pro Lys 
385                 390                 395                 400 


Ser Arg Glu Leu Arg Val Asn Arg Gly Leu Asp Thr Gly Arg Arg Arg 
                405                 410                 415     


Ala Ala Pro Glu Ala Ser Gly Thr Pro Ser Ser Asp Ala Val Ser Arg 
            420                 425                 430         


Leu Glu Glu Glu Met Arg Lys Leu Gln Ala Thr Val Gln Glu Leu Gln 
        435                 440                 445             


Lys Arg Leu Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
    450                 455                 460     


<210>  2473
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO1B__Homo_sapiens__NP_001018080

<400>  2473

Met Ser Phe Arg Lys Val Val Arg Gln Ser Lys Phe Arg His Val Phe 
1               5                   10                  15      


Gly Gln Pro Val Lys Asn Asp Gln Cys Tyr Glu Asp Ile Arg Val Ser 
            20                  25                  30          


Arg Val Thr Trp Asp Ser Thr Phe Cys Ala Val Asn Pro Lys Phe Leu 
        35                  40                  45              


Ala Val Ile Val Glu Ala Ser Gly Gly Gly Ala Phe Leu Val Leu Pro 
    50                  55                  60                  


Leu Ser Lys Thr Gly Arg Ile Asp Lys Ala Tyr Pro Thr Val Cys Gly 
65                  70                  75                  80  


His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Glu 
                85                  90                  95      


Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val Trp Gln Ile 
            100                 105                 110         


Pro Glu Asn Gly Leu Thr Ser Pro Leu Thr Glu Pro Val Val Val Leu 
        115                 120                 125             


Glu Gly His Thr Lys Arg Val Gly Ile Ile Ala Trp His Pro Thr Ala 
    130                 135                 140                 


Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Val Val Leu Ile Trp 
145                 150                 155                 160 


Asn Val Gly Thr Ala Glu Glu Leu Tyr Arg Leu Asp Ser Leu His Pro 
                165                 170                 175     


Asp Leu Ile Tyr Asn Val Ser Trp Asn His Asn Gly Ser Leu Phe Cys 
            180                 185                 190         


Ser Ala Cys Lys Asp Lys Ser Val Arg Ile Ile Asp Pro Arg Arg Gly 
        195                 200                 205             


Thr Leu Val Ala Glu Arg Glu Lys Ala His Glu Gly Ala Arg Pro Met 
    210                 215                 220                 


Arg Ala Ile Phe Leu Ala Asp Gly Lys Val Phe Thr Thr Gly Phe Ser 
225                 230                 235                 240 


Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asp Pro Glu Asn Leu Glu 
                245                 250                 255     


Glu Pro Met Ala Leu Gln Glu Leu Asp Ser Ser Asn Gly Ala Leu Leu 
            260                 265                 270         


Pro Phe Tyr Asp Pro Asp Thr Ser Val Val Tyr Val Cys Gly Lys Gly 
        275                 280                 285             


Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Glu Glu Pro Pro Tyr Ile 
    290                 295                 300                 


His Phe Leu Asn Thr Phe Thr Ser Lys Glu Pro Gln Arg Gly Met Gly 
305                 310                 315                 320 


Ser Met Pro Lys Arg Gly Leu Glu Val Ser Lys Cys Glu Ile Ala Arg 
                325                 330                 335     


Phe Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Val Met Thr Val 
            340                 345                 350         


Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Ala 
        355                 360                 365             


Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Val Ser Gly Arg Asp 
    370                 375                 380                 


Ala Asp Pro Ile Leu Ile Ser Leu Arg Glu Ala Tyr Val Pro Ser Lys 
385                 390                 395                 400 


Gln Arg Asp Leu Lys Ile Ser Arg Arg Asn Val Leu Ser Asp Ser Arg 
                405                 410                 415     


Pro Ala Met Ala Pro Gly Ser Ser His Leu Gly Ala Pro Ala Ser Thr 
            420                 425                 430         


Thr Thr Ala Ala Asp Ala Thr Pro Ser Gly Ser Leu Ala Arg Ala Gly 
        435                 440                 445             


Glu Ala Gly Lys Leu Glu Glu Val Met Gln Glu Leu Arg Ala Leu Arg 
    450                 455                 460                 


Ala Leu Val Lys Glu Gln Gly Asp Arg Ile Cys Arg Leu Glu Glu Gln 
465                 470                 475                 480 


Leu Gly Arg Met Glu Asn Gly Asp Ala 
                485                 


<210>  2474
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO1C__Homo_sapiens__NP_001098707

<400>  2474

Met Tyr Gly Pro Gly Ser Gln Leu Gly Lys Ser Gly Asn Asn Ser Trp 
1               5                   10                  15      


Ala Lys Glu Arg Gly Cys Ser Ile Ala Cys Gln Gly Ser Leu Thr Ser 
            20                  25                  30          


Ala Arg Leu His Ala Pro Ser Ile Gly Glu Arg Pro Leu Ser His Met 
        35                  40                  45              


Arg Trp Lys Asp Thr Met Arg Arg Val Val Arg Gln Ser Lys Phe Arg 
    50                  55                  60                  


His Val Phe Gly Gln Ala Val Lys Asn Asp Gln Cys Tyr Asp Asp Ile 
65                  70                  75                  80  


Arg Val Ser Arg Val Thr Trp Asp Ser Ser Phe Cys Ala Val Asn Pro 
                85                  90                  95      


Arg Phe Val Ala Ile Ile Ile Glu Ala Ser Gly Gly Gly Ala Phe Leu 
            100                 105                 110         


Val Leu Pro Leu His Lys Thr Gly Arg Ile Asp Lys Ser Tyr Pro Thr 
        115                 120                 125             


Val Cys Gly His Thr Gly Pro Val Leu Asp Ile Asp Trp Cys Pro His 
    130                 135                 140                 


Asn Asp Gln Val Ile Ala Ser Gly Ser Glu Asp Cys Thr Val Met Val 
145                 150                 155                 160 


Trp Gln Ile Pro Glu Asn Gly Leu Thr Leu Ser Leu Thr Glu Pro Val 
                165                 170                 175     


Val Ile Leu Glu Gly His Ser Lys Arg Val Gly Ile Val Ala Trp His 
            180                 185                 190         


Pro Thr Ala Arg Asn Val Leu Leu Ser Ala Gly Cys Asp Asn Ala Ile 
        195                 200                 205             


Ile Ile Trp Asn Val Gly Thr Gly Glu Ala Leu Ile Asn Leu Asp Asp 
    210                 215                 220                 


Met His Ser Asp Met Ile Tyr Asn Val Ser Trp Asn Arg Asn Gly Ser 
225                 230                 235                 240 


Leu Ile Cys Thr Ala Ser Lys Asp Lys Lys Val Arg Val Ile Asp Pro 
                245                 250                 255     


Arg Lys Gln Glu Ile Val Ala Glu Lys Glu Lys Ala His Glu Gly Ala 
            260                 265                 270         


Arg Pro Met Arg Ala Ile Phe Leu Ala Asp Gly Asn Val Phe Thr Thr 
        275                 280                 285             


Gly Phe Ser Arg Met Ser Glu Arg Gln Leu Ala Leu Trp Asn Pro Lys 
    290                 295                 300                 


Asn Met Gln Glu Pro Ile Ala Leu His Glu Met Asp Thr Ser Asn Gly 
305                 310                 315                 320 


Val Leu Leu Pro Phe Tyr Asp Pro Asp Thr Ser Ile Ile Tyr Leu Cys 
                325                 330                 335     


Gly Lys Gly Asp Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp Glu Ser 
            340                 345                 350         


Pro Tyr Val His Tyr Leu Asn Thr Phe Ser Ser Lys Glu Pro Gln Arg 
        355                 360                 365             


Gly Met Gly Tyr Met Pro Lys Arg Gly Leu Asp Val Asn Lys Cys Glu 
    370                 375                 380                 


Ile Ala Arg Phe Phe Lys Leu His Glu Arg Lys Cys Glu Pro Ile Ile 
385                 390                 395                 400 


Met Thr Val Pro Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro 
                405                 410                 415     


Asp Thr Ala Gly Pro Glu Ala Ala Leu Glu Ala Glu Glu Trp Phe Glu 
            420                 425                 430         


Gly Lys Asn Ala Asp Pro Ile Leu Ile Ser Leu Lys His Gly Tyr Ile 
        435                 440                 445             


Pro Gly Lys Asn Arg Asp Leu Lys Val Val Lys Lys Asn Ile Leu Asp 
    450                 455                 460                 


Ser Lys Pro Thr Ala Asn Lys Lys Cys Asp Leu Ile Ser Ile Pro Lys 
465                 470                 475                 480 


Lys Thr Thr Asp Thr Ala Ser Val Gln Asn Glu Ala Lys Leu Asp Glu 
                485                 490                 495     


Ile Leu Lys Glu Ile Lys Ser Ile Lys Asp Thr Ile Cys Asn Gln Asp 
            500                 505                 510         


Glu Arg Ile Ser Lys Leu Glu Gln Gln Met Ala Lys Ile Ala Ala 
        515                 520                 525         


<210>  2475
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO2A__Homo_sapiens__XP_011517288

<400>  2475

Met Ser Trp His Pro Gln Tyr Arg Ser Ser Lys Phe Arg His Val Phe 
1               5                   10                  15      


Gly Lys Pro Ala Ser Lys Glu Asn Cys Tyr Asp Ser Val Pro Ile Thr 
            20                  25                  30          


Arg Ser Val His Asp Asn His Phe Cys Ala Val Asn Pro His Phe Ile 
        35                  40                  45              


Ala Val Val Thr Glu Cys Ala Gly Gly Gly Ala Phe Leu Val Ile Pro 
    50                  55                  60                  


Leu His Gln Thr Gly Lys Leu Asp Pro His Tyr Pro Lys Val Cys Gly 
65                  70                  75                  80  


His Arg Gly Asn Val Leu Asp Val Lys Trp Asn Pro Phe Asp Asp Phe 
                85                  90                  95      


Glu Ile Ala Ser Cys Ser Glu Asp Ala Thr Ile Lys Ile Trp Ser Ile 
            100                 105                 110         


Pro Lys Gln Leu Leu Thr Arg Asn Leu Thr Ala Tyr Arg Lys Glu Leu 
        115                 120                 125             


Val Gly His Ala Arg Arg Val Gly Leu Val Glu Trp His Pro Thr Ala 
    130                 135                 140                 


Ala Asn Ile Leu Phe Ser Ala Gly Tyr Asp Tyr Lys Val Met Ile Trp 
145                 150                 155                 160 


Asn Leu Asp Thr Lys Glu Ser Val Ile Thr Ser Pro Met Ser Thr Ile 
                165                 170                 175     


Ser Cys His Gln Asp Val Ile Leu Ser Met Ser Phe Asn Thr Asn Gly 
            180                 185                 190         


Ser Leu Leu Ala Thr Thr Cys Lys Asp Arg Lys Ile Arg Val Ile Asp 
        195                 200                 205             


Pro Arg Ala Gly Thr Val Leu Gln Glu Ala Ser Tyr Lys Gly His Arg 
    210                 215                 220                 


Ala Ser Lys Val Leu Phe Leu Gly Asn Leu Lys Lys Leu Met Ser Thr 
225                 230                 235                 240 


Gly Thr Ser Arg Trp Asn Asn Arg Gln Val Ala Leu Trp Asp Gln Asp 
                245                 250                 255     


Asn Leu Ser Val Pro Leu Met Glu Glu Asp Leu Asp Gly Ser Ser Gly 
            260                 265                 270         


Val Leu Phe Pro Phe Tyr Asp Ala Asp Thr Ser Met Leu Tyr Val Val 
        275                 280                 285             


Gly Lys Gly Asp Gly Asn Ile Arg Tyr Tyr Glu Val Ser Ala Asp Lys 
    290                 295                 300                 


Pro His Leu Ser Tyr Leu Thr Glu Tyr Arg Ser Tyr Asn Pro Gln Lys 
305                 310                 315                 320 


Gly Ile Gly Val Met Pro Lys Arg Gly Leu Asp Val Ser Ser Cys Glu 
                325                 330                 335     


Ile Phe Arg Phe Tyr Lys Leu Ile Thr Thr Lys Ser Leu Ile Glu Pro 
            340                 345                 350         


Ile Ser Met Ile Val Pro Arg Arg Ser Glu Ser Tyr Gln Glu Asp Ile 
        355                 360                 365             


Tyr Pro Pro Thr Ala Gly Ala Gln Pro Ser Leu Thr Ala Gln Glu Trp 
    370                 375                 380                 


Leu Ser Gly Met Asn Arg Asp Pro Ile Leu Val Ser Leu Arg Pro Gly 
385                 390                 395                 400 


Ser Glu Leu Leu Arg Pro His Pro Leu Pro Ala Glu Arg Pro Ile Phe 
                405                 410                 415     


Asn Ser Met Ala Pro Ala Ser Pro Arg Leu Leu Asn Gln Thr Glu Lys 
            420                 425                 430         


Leu Ala Ala Glu Asp Gly Trp Arg Ser Ser Ser Leu Leu Glu Glu Lys 
        435                 440                 445             


Met Pro Arg Trp Ala Ala Glu His Arg Leu Glu Glu Lys Lys Thr Trp 
    450                 455                 460                 


Leu Thr Asn Gly Phe Asp Val Phe Glu Cys Pro Pro Pro Lys Thr Glu 
465                 470                 475                 480 


Asn Glu Leu Leu Gln Met Phe Tyr Arg Gln Gln Glu Glu Ile Arg Arg 
                485                 490                 495     


Leu Arg Glu Leu Leu Thr Gln Arg Glu Val Gln Ala Lys Gln Leu Glu 
            500                 505                 510         


Leu Glu Ile Lys Asn Leu Arg Met Gly Ser Glu Gln Leu 
        515                 520                 525 


<210>  2476
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO2B__Homo_sapiens__NP_001177385

<400>  2476

Met Ser Trp Arg Pro Gln Tyr Arg Ser Ser Lys Phe Arg Asn Val Tyr 
1               5                   10                  15      


Gly Lys Val Ala Asn Arg Glu His Cys Phe Asp Gly Ile Pro Ile Thr 
            20                  25                  30          


Lys Asn Val His Asp Asn His Phe Cys Ala Val Asn Thr Arg Phe Leu 
        35                  40                  45              


Ala Ile Val Thr Glu Ser Ala Gly Gly Gly Ser Phe Leu Val Ile Pro 
    50                  55                  60                  


Leu Glu Gln Thr Gly Arg Ile Glu Pro Asn Tyr Pro Lys Val Cys Gly 
65                  70                  75                  80  


His Gln Gly Asn Val Leu Asp Ile Lys Trp Asn Pro Phe Ile Asp Asn 
                85                  90                  95      


Ile Ile Ala Ser Cys Ser Glu Asp Thr Ser Val Arg Ile Trp Glu Ile 
            100                 105                 110         


Pro Glu Gly Gly Leu Lys Arg Asn Met Thr Glu Ala Leu Leu Glu Leu 
        115                 120                 125             


His Gly His Ser Arg Arg Val Gly Leu Val Glu Trp His Pro Thr Thr 
    130                 135                 140                 


Asn Asn Ile Leu Phe Ser Ala Gly Tyr Asp Tyr Lys Val Leu Ile Trp 
145                 150                 155                 160 


Asn Leu Asp Val Gly Glu Pro Val Lys Met Ile Asp Cys His Thr Asp 
                165                 170                 175     


Val Ile Leu Cys Met Ser Phe Asn Thr Asp Gly Ser Leu Leu Thr Thr 
            180                 185                 190         


Thr Cys Lys Asp Lys Lys Leu Arg Val Ile Glu Pro Arg Ser Gly Arg 
        195                 200                 205             


Val Leu Gln Glu Ala Asn Cys Lys Asn His Arg Val Asn Arg Val Val 
    210                 215                 220                 


Phe Leu Gly Asn Met Lys Arg Leu Leu Thr Thr Gly Val Ser Arg Trp 
225                 230                 235                 240 


Asn Thr Arg Gln Ile Ala Leu Trp Asp Gln Glu Asp Leu Ser Met Pro 
                245                 250                 255     


Leu Ile Glu Glu Glu Ile Asp Gly Leu Ser Gly Leu Leu Phe Pro Phe 
            260                 265                 270         


Tyr Asp Ala Asp Thr His Met Leu Tyr Leu Ala Gly Lys Gly Asp Gly 
        275                 280                 285             


Asn Ile Arg Tyr Tyr Glu Ile Ser Thr Glu Lys Pro Tyr Leu Ser Tyr 
    290                 295                 300                 


Leu Met Glu Phe Arg Ser Pro Ala Pro Gln Lys Gly Leu Gly Val Met 
305                 310                 315                 320 


Pro Lys His Gly Leu Asp Val Ser Ala Cys Glu Val Phe Arg Phe Tyr 
                325                 330                 335     


Lys Leu Val Thr Leu Lys Gly Leu Ile Glu Pro Ile Ser Met Ile Val 
            340                 345                 350         


Pro Arg Arg Ser Asp Ser Tyr Gln Glu Asp Ile Tyr Pro Met Thr Pro 
        355                 360                 365             


Gly Thr Glu Pro Ala Leu Thr Pro Asp Glu Trp Leu Gly Gly Ile Asn 
    370                 375                 380                 


Arg Asp Pro Val Leu Met Ser Leu Lys Glu Gly Tyr Lys Lys Ser Ser 
385                 390                 395                 400 


Lys Met Val Phe Lys Ala Pro Ile Lys Glu Lys Lys Ser Val Val Val 
                405                 410                 415     


Asn Gly Ile Asp Leu Leu Glu Asn Val Pro Pro Arg Thr Glu Asn Glu 
            420                 425                 430         


Leu Leu Arg Met Phe Phe Arg Gln Gln Asp Glu Ile Arg Arg Leu Lys 
        435                 440                 445             


Glu Glu Leu Ala Gln Lys Asp Ile Arg Ile Arg Gln Leu Gln Leu Glu 
    450                 455                 460                 


Leu Lys Asn Leu Arg Asn Ser Pro Lys Asn Cys 
465                 470                 475 


<210>  2477
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO6__Homo_sapiens__NP_116243

<400>  2477

Met Ser Arg Arg Val Val Arg Gln Ser Lys Phe Arg His Val Phe Gly 
1               5                   10                  15      


Gln Ala Ala Lys Ala Asp Gln Ala Tyr Glu Asp Ile Arg Val Ser Lys 
            20                  25                  30          


Val Thr Trp Asp Ser Ser Phe Cys Ala Val Asn Pro Lys Phe Leu Ala 
        35                  40                  45              


Ile Ile Val Glu Ala Gly Gly Gly Gly Ala Phe Ile Val Leu Pro Leu 
    50                  55                  60                  


Ala Lys Thr Gly Arg Val Asp Lys Asn Tyr Pro Leu Val Thr Gly His 
65                  70                  75                  80  


Thr Ala Pro Val Leu Asp Ile Asp Trp Cys Pro His Asn Asp Asn Val 
                85                  90                  95      


Ile Ala Ser Ala Ser Asp Asp Thr Thr Ile Met Val Trp Gln Ile Pro 
            100                 105                 110         


Asp Tyr Thr Pro Met Arg Asn Ile Thr Glu Pro Ile Ile Thr Leu Glu 
        115                 120                 125             


Gly His Ser Lys Arg Val Gly Ile Leu Ser Trp His Pro Thr Ala Arg 
    130                 135                 140                 


Asn Val Leu Leu Ser Ala Gly Gly Asp Asn Val Ile Ile Ile Trp Asn 
145                 150                 155                 160 


Val Gly Thr Gly Glu Val Leu Leu Ser Leu Asp Asp Met His Pro Asp 
                165                 170                 175     


Val Ile His Ser Val Cys Trp Asn Ser Asn Gly Ser Leu Leu Ala Thr 
            180                 185                 190         


Thr Cys Lys Asp Lys Thr Leu Arg Ile Ile Asp Pro Arg Lys Gly Gln 
        195                 200                 205             


Val Val Ala Glu Arg Phe Ala Ala His Glu Gly Met Arg Pro Met Arg 
    210                 215                 220                 


Ala Val Phe Thr Arg Gln Gly His Ile Phe Thr Thr Gly Phe Thr Arg 
225                 230                 235                 240 


Met Ser Gln Arg Glu Leu Gly Leu Trp Asp Pro Asn Asn Phe Glu Glu 
                245                 250                 255     


Pro Val Ala Leu Gln Glu Met Asp Thr Ser Asn Gly Val Leu Leu Pro 
            260                 265                 270         


Phe Tyr Asp Pro Asp Ser Ser Ile Val Tyr Leu Cys Gly Lys Gly Asp 
        275                 280                 285             


Ser Ser Ile Arg Tyr Phe Glu Ile Thr Asp Glu Pro Pro Phe Val His 
    290                 295                 300                 


Tyr Leu Asn Thr Phe Ser Ser Lys Glu Pro Gln Arg Gly Met Gly Phe 
305                 310                 315                 320 


Met Pro Lys Arg Gly Leu Asp Val Ser Lys Cys Glu Ile Ala Arg Phe 
                325                 330                 335     


Tyr Lys Leu His Glu Arg Lys Cys Glu Pro Ile Ile Met Thr Val Pro 
            340                 345                 350         


Arg Lys Ser Asp Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Pro Gly 
        355                 360                 365             


Pro Glu Pro Ala Leu Glu Ala Asp Glu Trp Leu Ser Gly Gln Asp Ala 
    370                 375                 380                 


Glu Pro Val Leu Ile Ser Leu Arg Asp Gly Tyr Val Pro Pro Lys His 
385                 390                 395                 400 


Arg Glu Leu Arg Val Thr Lys Arg Asn Ile Leu Asp Val Arg Pro Pro 
                405                 410                 415     


Ser Gly Pro Arg Arg Ser Gln Ser Ala Ser Asp Ala Pro Leu Ser Gln 
            420                 425                 430         


Gln His Thr Leu Glu Thr Leu Leu Glu Glu Ile Lys Ala Leu Arg Glu 
        435                 440                 445             


Arg Val Gln Ala Gln Glu Gln Arg Ile Thr Ala Leu Glu Asn Met Leu 
    450                 455                 460                 


Cys Glu Leu Val Asp Gly Thr Asp 
465                 470         


<210>  2478
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO7__Homo_sapiens__NP_001188402

<400>  2478

Met Asn Arg Phe Arg Val Ser Lys Phe Arg His Thr Glu Ala Arg Pro 
1               5                   10                  15      


Pro Arg Arg Glu Ser Trp Ile Ser Asp Ile Arg Ala Gly Thr Ala Pro 
            20                  25                  30          


Ser Cys Arg Asn His Ile Lys Ser Ser Cys Ser Leu Ile Ala Phe Asn 
        35                  40                  45              


Ser Asp Arg Pro Gly Val Leu Gly Ile Val Pro Leu Gln Gly Gln Gly 
    50                  55                  60                  


Glu Asp Lys Arg Arg Val Ala His Leu Gly Cys His Ser Glu Leu Ala 
65                  70                  75                  80  


Ala His Gly Asp Leu Val Gln Ser Ala Val Trp Ser Arg Asp Gly Ala 
                85                  90                  95      


Leu Val Gly Thr Ala Cys Lys Asp Lys Gln Leu Arg Ile Phe Asp Pro 
            100                 105                 110         


Arg Thr Lys Pro Arg Ala Ser Gln Ser Thr Gln Ala His Glu Asn Ser 
        115                 120                 125             


Arg Asp Ser Arg Leu Ala Trp Met Gly Thr Trp Glu His Leu Val Ser 
    130                 135                 140                 


Thr Gly Phe Asn Gln Met Arg Glu Arg Glu Val Lys Leu Trp Asp Thr 
145                 150                 155                 160 


Arg Phe Phe Ser Ser Ala Leu Ala Ser Leu Thr Leu Asp Thr Ser Leu 
                165                 170                 175     


Gly Cys Leu Val Pro Leu Leu Asp Pro Asp Ser Gly Leu Leu Val Leu 
            180                 185                 190         


Ala Gly Lys Gly Glu Arg Gln Leu Tyr Cys Tyr Glu Val Val Pro Gln 
        195                 200                 205             


Gln Pro Ala Leu Ser Pro Val Thr Gln Cys Val Leu Glu Ser Val Leu 
    210                 215                 220                 


Arg Gly Ala Ala Leu Val Pro Arg Gln Ala Leu Ala Val Met Ser Cys 
225                 230                 235                 240 


Glu Val Leu Arg Val Leu Gln Leu Ser Asp Thr Ala Ile Val Pro Ile 
                245                 250                 255     


Gly Tyr His Val Pro Arg Lys Ala Val Glu Phe His Glu Asp Leu Phe 
            260                 265                 270         


Pro Asp Thr Ala Gly Cys Val Pro Ala Thr Asp Pro His Ser Trp Trp 
        275                 280                 285             


Ala Gly Asp Asn Gln Gln Val Gln Lys Val Ser Leu Asn Pro Ala Cys 
    290                 295                 300                 


Arg Pro His Pro Ser Phe Thr Ser Cys Leu Val Pro Pro Ala Glu Pro 
305                 310                 315                 320 


Leu Pro Asp Thr Ala Gln Pro Ala Val Met Glu Thr Pro Val Gly Asp 
                325                 330                 335     


Ala Asp Ala Ser Glu Gly Phe Ser Ser Pro Pro Ser Ser Leu Thr Ser 
            340                 345                 350         


Pro Ser Thr Pro Ser Ser Leu Gly Pro Ser Leu Ser Ser Thr Ser Gly 
        355                 360                 365             


Ile Gly Thr Ser Pro Ser Leu Arg Ser Leu Gln Ser Leu Leu Gly Pro 
    370                 375                 380                 


Ser Ser Lys Phe Arg His Ala Gln Gly Thr Val Leu His Arg Asp Ser 
385                 390                 395                 400 


His Ile Thr Asn Leu Lys Gly Leu Asn Leu Thr Thr Pro Gly Glu Ser 
                405                 410                 415     


Asp Gly Phe Cys Ala Asn Lys Leu Arg Val Ala Val Pro Leu Leu Ser 
            420                 425                 430         


Ser Gly Gly Gln Val Ala Val Leu Glu Leu Arg Lys Pro Gly Arg Leu 
        435                 440                 445             


Pro Asp Thr Ala Leu Pro Thr Leu Gln Asn Gly Ala Ala Val Thr Asp 
    450                 455                 460                 


Leu Ala Trp Asp Pro Phe Asp Pro His Arg Leu Ala Val Ala Gly Glu 
465                 470                 475                 480 


Asp Ala Arg Ile Arg Leu Trp Arg Val Pro Ala Glu Gly Leu Glu Glu 
                485                 490                 495     


Val Leu Thr Thr Pro Glu Thr Val Leu Thr Gly His Thr Glu Lys Ile 
            500                 505                 510         


Cys Ser Leu Arg Phe His Pro Leu Ala Ala Asn Val Leu Ala Ser Ser 
        515                 520                 525             


Ser Tyr Asp Leu Thr Val Arg Ile Trp Asp Leu Gln Ala Gly Ala Asp 
    530                 535                 540                 


Arg Leu Lys Leu Gln Gly His Gln Asp Gln Ile Phe Ser Leu Ala Trp 
545                 550                 555                 560 


Ser Pro Asp Gly Gln Gln Leu Ala Thr Val Cys Lys Asp Gly Arg Val 
                565                 570                 575     


Arg Val Tyr Arg Pro Arg Ser Gly Pro Glu Pro Leu Gln Glu Gly Pro 
            580                 585                 590         


Gly Pro Lys Gly Gly Arg Gly Ala Arg Ile Val Trp Val Cys Asp Gly 
        595                 600                 605             


Arg Cys Leu Leu Val Ser Gly Phe Asp Ser Gln Ser Glu Arg Gln Leu 
    610                 615                 620                 


Leu Leu Tyr Glu Ala Glu Ala Leu Ala Gly Gly Pro Leu Ala Val Leu 
625                 630                 635                 640 


Gly Leu Asp Val Ala Pro Ser Thr Leu Leu Pro Ser Tyr Asp Pro Asp 
                645                 650                 655     


Thr Gly Leu Val Leu Leu Thr Gly Lys Gly Asp Thr Arg Val Phe Leu 
            660                 665                 670         


Tyr Glu Leu Leu Pro Glu Ser Pro Phe Phe Leu Glu Cys Asn Ser Phe 
        675                 680                 685             


Thr Ser Pro Asp Pro His Lys Gly Leu Val Leu Leu Pro Lys Thr Glu 
    690                 695                 700                 


Cys Asp Val Arg Glu Val Glu Leu Met Arg Cys Leu Arg Leu Arg Gln 
705                 710                 715                 720 


Ser Ser Leu Glu Pro Val Ala Phe Arg Leu Pro Arg Val Arg Lys Glu 
                725                 730                 735     


Phe Phe Gln Asp Asp Val Phe Pro Asp Thr Ala Val Ile Trp Glu Pro 
            740                 745                 750         


Val Leu Ser Ala Glu Ala Trp Leu Gln Gly Ala Asn Gly Gln Pro Trp 
        755                 760                 765             


Leu Leu Ser Leu Gln Pro Pro Asp Met Ser Pro Val Ser Gln Ala Pro 
    770                 775                 780                 


Arg Glu Ala Pro Ala Arg Arg Ala Pro Ser Ser Ala Gln Tyr Leu Glu 
785                 790                 795                 800 


Glu Lys Ser Asp Gln Gln Lys Lys Glu Glu Leu Leu Asn Ala Met Val 
                805                 810                 815     


Ala Lys Leu Gly Asn Arg Glu Asp Pro Leu Pro Gln Asp Ser Phe Glu 
            820                 825                 830         


Gly Val Asp Glu Asp Glu Trp Asp 
        835                 840 


<210>  2479
<211>  1048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CORO7-PAM16__Homo_sapiens__NP_001188408

<400>  2479

Met Asn Arg Phe Arg Val Ser Lys Phe Arg His Thr Glu Ala Arg Pro 
1               5                   10                  15      


Pro Arg Arg Glu Ser Trp Ile Ser Asp Ile Arg Ala Gly Thr Ala Pro 
            20                  25                  30          


Ser Cys Arg Asn His Ile Lys Ser Ser Cys Ser Leu Ile Ala Phe Asn 
        35                  40                  45              


Ser Asp Arg Pro Gly Val Leu Gly Ile Val Pro Leu Gln Gly Gln Gly 
    50                  55                  60                  


Glu Asp Lys Arg Arg Val Ala His Leu Gly Cys His Ser Asp Leu Val 
65                  70                  75                  80  


Thr Asp Leu Asp Phe Ser Pro Phe Asp Asp Phe Leu Leu Ala Thr Gly 
                85                  90                  95      


Ser Ala Asp Arg Thr Val Lys Leu Trp Arg Leu Pro Gly Pro Gly Gln 
            100                 105                 110         


Ala Leu Pro Ser Ala Pro Gly Val Val Leu Gly Pro Glu Asp Leu Pro 
        115                 120                 125             


Val Glu Val Leu Gln Phe His Pro Thr Ser Asp Gly Ile Leu Val Ser 
    130                 135                 140                 


Ala Ala Gly Thr Thr Val Lys Val Trp Asp Ala Ala Lys Gln Gln Pro 
145                 150                 155                 160 


Leu Thr Glu Leu Ala Ala His Gly Asp Leu Val Gln Ser Ala Val Trp 
                165                 170                 175     


Ser Arg Asp Gly Ala Leu Val Gly Thr Ala Cys Lys Asp Lys Gln Leu 
            180                 185                 190         


Arg Ile Phe Asp Pro Arg Thr Lys Pro Arg Ala Ser Gln Ser Thr Gln 
        195                 200                 205             


Ala His Glu Asn Ser Arg Asp Ser Arg Leu Ala Trp Met Gly Thr Trp 
    210                 215                 220                 


Glu His Leu Val Ser Thr Gly Phe Asn Gln Met Arg Glu Arg Glu Val 
225                 230                 235                 240 


Lys Leu Trp Asp Thr Arg Phe Phe Ser Ser Ala Leu Ala Ser Leu Thr 
                245                 250                 255     


Leu Asp Thr Ser Leu Gly Cys Leu Val Pro Leu Leu Asp Pro Asp Ser 
            260                 265                 270         


Gly Leu Leu Val Leu Ala Gly Lys Gly Glu Arg Gln Leu Tyr Cys Tyr 
        275                 280                 285             


Glu Val Val Pro Gln Gln Pro Ala Leu Ser Pro Val Thr Gln Cys Val 
    290                 295                 300                 


Leu Glu Ser Val Leu Arg Gly Ala Ala Leu Val Pro Arg Gln Ala Leu 
305                 310                 315                 320 


Ala Val Met Ser Cys Glu Val Leu Arg Val Leu Gln Leu Ser Asp Thr 
                325                 330                 335     


Ala Ile Val Pro Ile Gly Tyr His Val Pro Arg Lys Ala Val Glu Phe 
            340                 345                 350         


His Glu Asp Leu Phe Pro Asp Thr Ala Gly Cys Val Pro Ala Thr Asp 
        355                 360                 365             


Pro His Ser Trp Trp Ala Gly Asp Asn Gln Gln Val Gln Lys Val Ser 
    370                 375                 380                 


Leu Asn Pro Ala Cys Arg Pro His Pro Ser Phe Thr Ser Cys Leu Val 
385                 390                 395                 400 


Pro Pro Ala Glu Pro Leu Pro Asp Thr Ala Gln Pro Ala Val Met Glu 
                405                 410                 415     


Thr Pro Val Gly Asp Ala Asp Ala Ser Glu Gly Phe Ser Ser Pro Pro 
            420                 425                 430         


Ser Ser Leu Thr Ser Pro Ser Thr Pro Ser Ser Leu Gly Pro Ser Leu 
        435                 440                 445             


Ser Ser Thr Ser Gly Ile Gly Thr Ser Pro Ser Leu Arg Ser Leu Gln 
    450                 455                 460                 


Ser Leu Leu Gly Pro Ser Ser Lys Phe Arg His Ala Gln Gly Thr Val 
465                 470                 475                 480 


Leu His Arg Asp Ser His Ile Thr Asn Leu Lys Gly Leu Asn Leu Thr 
                485                 490                 495     


Thr Pro Gly Glu Ser Asp Gly Phe Cys Ala Asn Lys Leu Arg Val Ala 
            500                 505                 510         


Val Pro Leu Leu Ser Ser Gly Gly Gln Val Ala Val Leu Glu Leu Arg 
        515                 520                 525             


Lys Pro Gly Arg Leu Pro Asp Thr Ala Leu Pro Thr Leu Gln Asn Gly 
    530                 535                 540                 


Ala Ala Val Thr Asp Leu Ala Trp Asp Pro Phe Asp Pro His Arg Leu 
545                 550                 555                 560 


Ala Val Ala Gly Glu Asp Ala Arg Ile Arg Leu Trp Arg Val Pro Ala 
                565                 570                 575     


Glu Gly Leu Glu Glu Val Leu Thr Thr Pro Glu Thr Val Leu Thr Gly 
            580                 585                 590         


His Thr Glu Lys Ile Cys Ser Leu Arg Phe His Pro Leu Ala Ala Asn 
        595                 600                 605             


Val Leu Ala Ser Ser Ser Tyr Asp Leu Thr Val Arg Ile Trp Asp Leu 
    610                 615                 620                 


Gln Ala Gly Ala Asp Arg Leu Lys Leu Gln Gly His Gln Asp Gln Ile 
625                 630                 635                 640 


Phe Ser Leu Ala Trp Ser Pro Asp Gly Gln Gln Leu Ala Thr Val Cys 
                645                 650                 655     


Lys Asp Gly Arg Val Arg Val Tyr Arg Pro Arg Ser Gly Pro Glu Pro 
            660                 665                 670         


Leu Gln Glu Gly Pro Gly Pro Lys Gly Gly Arg Gly Ala Arg Ile Val 
        675                 680                 685             


Trp Val Cys Asp Gly Arg Cys Leu Leu Val Ser Gly Phe Asp Ser Gln 
    690                 695                 700                 


Ser Glu Arg Gln Leu Leu Leu Tyr Glu Ala Glu Ala Leu Ala Gly Gly 
705                 710                 715                 720 


Pro Leu Ala Val Leu Gly Leu Asp Val Ala Pro Ser Thr Leu Leu Pro 
                725                 730                 735     


Ser Tyr Asp Pro Asp Thr Gly Leu Val Leu Leu Thr Gly Lys Gly Asp 
            740                 745                 750         


Thr Arg Val Phe Leu Tyr Glu Leu Leu Pro Glu Ser Pro Phe Phe Leu 
        755                 760                 765             


Glu Cys Asn Ser Phe Thr Ser Pro Asp Pro His Lys Gly Leu Val Leu 
    770                 775                 780                 


Leu Pro Lys Thr Glu Cys Asp Val Arg Glu Val Glu Leu Met Arg Cys 
785                 790                 795                 800 


Leu Arg Leu Arg Gln Ser Ser Leu Glu Pro Val Ala Phe Arg Leu Pro 
                805                 810                 815     


Arg Val Arg Lys Glu Phe Phe Gln Asp Asp Val Phe Pro Asp Thr Ala 
            820                 825                 830         


Val Ile Trp Glu Pro Val Leu Ser Ala Glu Ala Trp Leu Gln Gly Ala 
        835                 840                 845             


Asn Gly Gln Pro Trp Leu Leu Ser Leu Gln Pro Pro Asp Met Ser Pro 
    850                 855                 860                 


Val Ser Gln Ala Pro Arg Glu Ala Pro Ala Arg Arg Ala Pro Ser Ser 
865                 870                 875                 880 


Ala Gln Tyr Leu Glu Glu Lys Ser Asp Gln Gln Lys Lys Glu Glu Leu 
                885                 890                 895     


Leu Asn Ala Met Val Ala Lys Leu Gly Asn Arg Glu Asp Pro Leu Pro 
            900                 905                 910         


Gln Asp Ser Phe Glu Gly Val Asp Glu Asp Glu Trp Ala Lys Tyr Leu 
        915                 920                 925             


Ala Gln Ile Ile Val Met Gly Val Gln Val Val Gly Arg Ala Phe Ala 
    930                 935                 940                 


Arg Ala Leu Arg Gln Glu Phe Ala Ala Ser Arg Ala Ala Ala Asp Ala 
945                 950                 955                 960 


Arg Gly Arg Ala Gly His Arg Ser Ala Ala Ala Ser Asn Leu Ser Gly 
                965                 970                 975     


Leu Ser Leu Gln Glu Ala Gln Gln Ile Leu Asn Val Ser Lys Leu Ser 
            980                 985                 990         


Pro Glu Glu Val Gln Lys Asn Tyr  Glu His Leu Phe Lys  Val Asn Asp 
        995                 1000                 1005             


Lys Ser  Val Gly Gly Ser Phe  Tyr Leu Gln Ser Lys  Val Val Arg 
    1010                 1015                 1020             


Ala Lys  Glu Arg Leu Asp Glu  Glu Leu Lys Ile Gln  Ala Gln Glu 
    1025                 1030                 1035             


Asp Arg  Glu Lys Gly Gln Met  Pro His Thr 
    1040                 1045             


<210>  2480
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COTL1__Homo_sapiens__NP_066972

<400>  2480

Met Ala Thr Lys Ile Asp Lys Glu Ala Cys Arg Ala Ala Tyr Asn Leu 
1               5                   10                  15      


Val Arg Asp Asp Gly Ser Ala Val Ile Trp Val Thr Phe Lys Tyr Asp 
            20                  25                  30          


Gly Ser Thr Ile Val Pro Gly Glu Gln Gly Ala Glu Tyr Gln His Phe 
        35                  40                  45              


Ile Gln Gln Cys Thr Asp Asp Val Arg Leu Phe Ala Phe Val Arg Phe 
    50                  55                  60                  


Thr Thr Gly Asp Ala Met Ser Lys Arg Ser Lys Phe Ala Leu Ile Thr 
65                  70                  75                  80  


Trp Ile Gly Glu Asn Val Ser Gly Leu Gln Arg Ala Lys Thr Gly Thr 
                85                  90                  95      


Asp Lys Thr Leu Val Lys Glu Val Val Gln Asn Phe Ala Lys Glu Phe 
            100                 105                 110         


Val Ile Ser Asp Arg Lys Glu Leu Glu Glu Asp Phe Ile Lys Ser Glu 
        115                 120                 125             


Leu Lys Lys Ala Gly Gly Ala Asn Tyr Asp Ala Gln Thr Glu 
    130                 135                 140         


<210>  2481
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX10__Homo_sapiens__XP_005256515

<400>  2481

Met Ala Ala Ser Pro His Thr Leu Ser Ser Arg Leu Leu Thr Gly Cys 
1               5                   10                  15      


Val Gly Gly Ser Val Trp Tyr Leu Glu Arg Arg Thr Ile Gln Asp Ser 
            20                  25                  30          


Pro His Lys Phe Leu His Leu Leu Arg Asn Val Asn Lys Gln Trp Ile 
        35                  40                  45              


Thr Phe Gln His Phe Ser Phe Leu Lys Arg Met Tyr Val Thr Gln Leu 
    50                  55                  60                  


Asn Arg Ser His Asn Gln Gln Val Arg Pro Lys Pro Glu Pro Val Ala 
65                  70                  75                  80  


Ser Pro Phe Leu Glu Lys Thr Ser Ser Gly Gln Ala Lys Ala Glu Ile 
                85                  90                  95      


Tyr Glu Met Arg Pro Leu Ser Pro Pro Ser Leu Ser Leu Ser Arg Lys 
            100                 105                 110         


Pro Asn Glu Lys Glu Leu Ile Glu Leu Glu Pro Asp Ser Val Ile Glu 
        115                 120                 125             


Asp Ser Ile Asp Val Gly Lys Glu Thr Lys Glu Glu Lys Arg Trp Lys 
    130                 135                 140                 


Glu Met Lys Leu Gln Val Tyr Asp Leu Pro Gly Ile Leu Ala Arg Leu 
145                 150                 155                 160 


Ser Lys Ile Lys Leu Thr Ala Leu Val Val Ser Thr Thr Ala Ala Gly 
                165                 170                 175     


Phe Ala Leu Ala Pro Gly Pro Phe Asp Trp Pro Cys Phe Leu Leu Thr 
            180                 185                 190         


Ser Val Gly Thr Gly Leu Ala Ser Cys Ala Ala Asn Ser Ile Asn Gln 
        195                 200                 205             


Phe Phe Glu Val Pro Phe Asp Ser Asn Met Asn Arg Thr Lys Asn Arg 
    210                 215                 220                 


Pro Leu Val Arg Gly Gln Ile Arg Gln Ser Phe Phe Ser Ser Phe 
225                 230                 235                 


<210>  2482
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX11__Homo_sapiens__NP_001156333

<400>  2482

Met Gly Gly Leu Trp Arg Pro Gly Trp Arg Cys Val Pro Phe Cys Gly 
1               5                   10                  15      


Trp Arg Trp Ile His Pro Gly Ser Pro Thr Arg Ala Ala Glu Arg Val 
            20                  25                  30          


Glu Pro Phe Leu Arg Pro Glu Trp Ser Gly Thr Gly Gly Ala Glu Arg 
        35                  40                  45              


Gly Leu Arg Trp Leu Gly Thr Trp Lys Arg Cys Ser Leu Arg Ala Arg 
    50                  55                  60                  


His Pro Ala Leu Gln Pro Pro Arg Arg Pro Lys Ser Ser Asn Pro Phe 
65                  70                  75                  80  


Thr Arg Ala Gln Glu Glu Glu Arg Arg Arg Gln Asn Lys Thr Thr Leu 
                85                  90                  95      


Thr Tyr Val Ala Ala Val Ala Val Gly Met Leu Gly Ala Ser Tyr Ala 
            100                 105                 110         


Ala Val Pro Leu Tyr Arg Leu Tyr Cys Gln Thr Thr Gly Leu Gly Gly 
        115                 120                 125             


Ser Ala Val Ala Gly His Ala Ser Asp Lys Ile Glu Asn Met Val Pro 
    130                 135                 140                 


Val Lys Asp Arg Ile Ile Lys Ile Ser Phe Asn Ala Asp Val His Ala 
145                 150                 155                 160 


Ser Leu Gln Trp Asn Phe Arg Pro Gln Gln Thr Glu Ile Tyr Val Val 
                165                 170                 175     


Pro Gly Glu Thr Ala Leu Ala Phe Tyr Arg Ala Lys Asn Pro Thr Asp 
            180                 185                 190         


Lys Pro Val Ile Gly Ile Ser Thr Tyr Asn Ile Val Pro Phe Glu Ala 
        195                 200                 205             


Gly Gln Tyr Phe Asn Lys Ile Gln Val Leu Ser Ser Arg Leu Gln Ser 
    210                 215                 220                 


Cys Thr Glu Ser Thr Phe 
225                 230 


<210>  2483
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX14__Homo_sapiens__NP_001244062

<400>  2483

Met Pro Thr Gly Lys Gln Leu Ala Asp Ile Gly Tyr Lys Thr Phe Ser 
1               5                   10                  15      


Thr Ser Met Met Leu Leu Thr Val Tyr Gly Gly Tyr Leu Cys Ser Val 
            20                  25                  30          


Arg Val Tyr His Tyr Phe Gln Trp Arg Arg Ala Gln Arg Gln Ala Ala 
        35                  40                  45              


Glu Glu Gln Lys Thr Ser Gly Ile Met 
    50                  55          


<210>  2484
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX15__Homo_sapiens__NP_004367

<400>  2484

Met Gln Arg Leu Leu Phe Pro Pro Leu Arg Ala Leu Lys Gly Arg Gln 
1               5                   10                  15      


Tyr Leu Pro Leu Leu Ala Pro Arg Ala Ala Pro Arg Ala Gln Cys Asp 
            20                  25                  30          


Cys Ile Arg Arg Pro Leu Arg Pro Gly Gln Tyr Ser Thr Ile Ser Glu 
        35                  40                  45              


Val Ala Leu Gln Ser Gly Arg Gly Thr Val Ser Leu Pro Ser Lys Ala 
    50                  55                  60                  


Ala Glu Arg Val Val Gly Arg Trp Leu Leu Val Cys Ser Gly Thr Val 
65                  70                  75                  80  


Ala Gly Ala Val Ile Leu Gly Gly Val Thr Arg Leu Thr Glu Ser Gly 
                85                  90                  95      


Leu Ser Met Val Asp Trp His Leu Ile Lys Glu Met Lys Pro Pro Thr 
            100                 105                 110         


Ser Gln Glu Glu Trp Glu Ala Glu Phe Gln Arg Tyr Gln Gln Phe Pro 
        115                 120                 125             


Glu Phe Lys Ile Leu Asn His Asp Met Thr Leu Thr Glu Phe Lys Phe 
    130                 135                 140                 


Ile Trp Tyr Met Glu Tyr Ser His Arg Met Trp Gly Arg Leu Val Gly 
145                 150                 155                 160 


Leu Val Tyr Ile Leu Pro Ala Ala Tyr Phe Trp Arg Lys Gly Trp Leu 
                165                 170                 175     


Ser Arg Gly Met Lys Gly Arg Val Leu Ala Leu Cys Gly Leu Val Cys 
            180                 185                 190         


Phe Gln Gly Leu Leu Gly Trp Tyr Met Val Lys Ser Gly Leu Glu Glu 
        195                 200                 205             


Lys Ser Asp Ser His Asp Ile Pro Arg Val Ser Gln Tyr Arg Leu Ala 
    210                 215                 220                 


Ala His Leu Gly Ser Ala Leu Val Leu Tyr Cys Ala Ser Leu Trp Thr 
225                 230                 235                 240 


Ser Leu Ser Leu Leu Leu Pro Pro His Lys Leu Pro Glu Thr His Gln 
                245                 250                 255     


Leu Leu Gln Leu Arg Arg Phe Ala His Gly Thr Ala Gly Leu Val Phe 
            260                 265                 270         


Leu Thr Ala Leu Ser Gly Ala Phe Val Ala Gly Leu Asp Ala Gly Leu 
        275                 280                 285             


Val Tyr Asn Ser Phe Pro Lys Met Gly Glu Ser Trp Ile Pro Glu Asp 
    290                 295                 300                 


Leu Phe Thr Phe Ser Pro Ile Leu Arg Asn Val Phe Glu Asn Pro Thr 
305                 310                 315                 320 


Met Val Gln Phe Asp His Arg Ile Leu Gly Ile Thr Ser Val Thr Ala 
                325                 330                 335     


Ile Thr Val Leu Tyr Phe Leu Ser Arg Arg Ile Pro Leu Pro Arg Arg 
            340                 345                 350         


Thr Lys Met Ala Ala Val Thr Leu Leu Ala Leu Ala Tyr Thr Gln Gly 
        355                 360                 365             


Pro Val Leu Phe Asn Phe Thr Phe Lys Ile Ser Asp Leu Asp Glu Gly 
    370                 375                 380                 


Ile Arg Asn Ile 
385             


<210>  2485
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX16__Homo_sapiens__NP_057552

<400>  2485

Met Phe Ala Pro Ala Val Met Arg Ala Phe Arg Lys Asn Lys Thr Leu 
1               5                   10                  15      


Gly Tyr Gly Val Pro Met Leu Leu Leu Ile Val Gly Gly Ser Phe Gly 
            20                  25                  30          


Leu Arg Glu Phe Ser Gln Ile Arg Tyr Asp Ala Val Lys Ser Lys Met 
        35                  40                  45              


Asp Pro Glu Leu Glu Lys Lys Leu Lys Glu Asn Lys Ile Ser Leu Glu 
    50                  55                  60                  


Ser Glu Tyr Glu Lys Ile Lys Asp Ser Lys Phe Asp Asp Trp Lys Asn 
65                  70                  75                  80  


Ile Arg Gly Pro Arg Pro Trp Glu Asp Pro Asp Leu Leu Gln Gly Arg 
                85                  90                  95      


Asn Pro Glu Ser Leu Lys Thr Lys Thr Thr 
            100                 105     


<210>  2486
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX17__Homo_sapiens__NP_005685

<400>  2486

Met Pro Gly Leu Val Asp Ser Asn Pro Ala Pro Pro Glu Ser Gln Glu 
1               5                   10                  15      


Lys Lys Pro Leu Lys Pro Cys Cys Ala Cys Pro Glu Thr Lys Lys Ala 
            20                  25                  30          


Arg Asp Ala Cys Ile Ile Glu Lys Gly Glu Glu His Cys Gly His Leu 
        35                  40                  45              


Ile Glu Ala His Lys Glu Cys Met Arg Ala Leu Gly Phe Lys Ile 
    50                  55                  60              


<210>  2487
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX18__Homo_sapiens__NP_001284661

<400>  2487

Met Leu Cys Arg Leu Gly Gly Arg Trp Leu Arg Pro Leu Pro Ala Leu 
1               5                   10                  15      


Gln Leu Trp Ala Arg Asp Leu Pro Leu Ala Pro Val Pro Thr Ser Gly 
            20                  25                  30          


Ala Lys Arg Pro Thr Leu Pro Val Trp Ala Val Ala Pro Val Ser Ala 
        35                  40                  45              


Val His Ala Asn Gly Trp Tyr Glu Ala Leu Ala Ala Ser Ser Pro Val 
    50                  55                  60                  


Arg Val Ala Glu Glu Val Leu Leu Gly Val His Ala Ala Thr Gly Leu 
65                  70                  75                  80  


Pro Trp Trp Gly Ser Ile Leu Leu Ser Thr Val Ala Leu Arg Gly Ala 
                85                  90                  95      


Val Thr Leu Pro Leu Ala Ala Tyr Gln His Tyr Ile Leu Ala Lys Val 
            100                 105                 110         


Glu Asn Leu Gln Pro Glu Ile Lys Thr Ile Ala Arg His Leu Asn Gln 
        115                 120                 125             


Glu Val Ala Val Arg Ala Asn Gln Leu Gly Trp Ser Lys Arg Asp Ala 
    130                 135                 140                 


Arg Leu Thr Tyr Leu Lys Asn Met Arg Arg Leu Ile Ser Glu Leu Tyr 
145                 150                 155                 160 


Val Arg Asp Asn Cys His Pro Phe Lys Ala Thr Val Leu Val Trp Ile 
                165                 170                 175     


Gln Leu Pro Met Trp Ile Phe Met Ser Phe Ala Leu Arg Asn Leu Ser 
            180                 185                 190         


Thr Gly Ala Ala His Ser Glu Ala Gly Phe Ser Val Gln Glu Gln Leu 
        195                 200                 205             


Ala Thr Gly Gly Ile Leu Trp Phe Pro Asp Leu Thr Ala Pro Asp Ser 
    210                 215                 220                 


Thr Trp Ile Leu Pro Ile Ser Val Gly Val Ile Asn Leu Leu Ile Val 
225                 230                 235                 240 


Glu Ile Cys Ala Leu Gln Lys Ile Gly Met Ser Arg Phe Gln Thr Tyr 
                245                 250                 255     


Ile Thr Tyr Phe Val Arg Ala Met Ser Val Leu Met Ile Pro Ile Ala 
            260                 265                 270         


Ala Thr Val Pro Ser Ser Ile Val Leu Tyr Trp Leu Cys Ser Ser Phe 
        275                 280                 285             


Val Gly Leu Ser Gln Asn Leu Leu Leu Arg Ser Pro Gly Phe Arg Gln 
    290                 295                 300                 


Leu Cys Arg Ile Pro Ser Thr Lys Ser Asp Ser Glu Thr Pro Tyr Lys 
305                 310                 315                 320 


Asp Ile Phe Ala Ala Phe Asn Thr Lys Phe Ile Ser Arg Lys 
                325                 330                 


<210>  2488
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX19__Homo_sapiens__NP_001026788

<400>  2488

Met Ser Thr Ala Met Asn Phe Gly Thr Lys Ser Phe Gln Pro Arg Pro 
1               5                   10                  15      


Pro Asp Lys Gly Ser Phe Pro Leu Asp His Leu Gly Glu Cys Lys Ser 
            20                  25                  30          


Phe Lys Glu Lys Phe Met Lys Cys Leu His Asn Asn Asn Phe Glu Asn 
        35                  40                  45              


Ala Leu Cys Arg Lys Glu Ser Lys Glu Tyr Leu Glu Cys Arg Met Glu 
    50                  55                  60                  


Arg Lys Leu Met Leu Gln Glu Pro Leu Glu Lys Leu Gly Phe Gly Asp 
65                  70                  75                  80  


Leu Thr Ser Gly Lys Ser Glu Ala Lys Lys 
                85                  90  


<210>  2489
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX4I1__Homo_sapiens__NP_001852

<400>  2489

Met Leu Ala Thr Arg Val Phe Ser Leu Val Gly Lys Arg Ala Ile Ser 
1               5                   10                  15      


Thr Ser Val Cys Val Arg Ala His Glu Ser Val Val Lys Ser Glu Asp 
            20                  25                  30          


Phe Ser Leu Pro Ala Tyr Met Asp Arg Arg Asp His Pro Leu Pro Glu 
        35                  40                  45              


Val Ala His Val Lys His Leu Ser Ala Ser Gln Lys Ala Leu Lys Glu 
    50                  55                  60                  


Lys Glu Lys Ala Ser Trp Ser Ser Leu Ser Met Asp Glu Lys Val Glu 
65                  70                  75                  80  


Leu Tyr Arg Ile Lys Phe Lys Glu Ser Phe Ala Glu Met Asn Arg Gly 
                85                  90                  95      


Ser Asn Glu Trp Lys Thr Val Val Gly Gly Ala Met Phe Phe Ile Gly 
            100                 105                 110         


Phe Thr Ala Leu Val Ile Met Trp Gln Lys His Tyr Val Tyr Gly Pro 
        115                 120                 125             


Leu Pro Gln Ser Phe Asp Lys Glu Trp Val Ala Lys Gln Thr Lys Arg 
    130                 135                 140                 


Met Leu Asp Met Lys Val Asn Pro Ile Gln Gly Leu Ala Ser Lys Trp 
145                 150                 155                 160 


Asp Tyr Glu Lys Asn Glu Trp Lys Lys 
                165                 


<210>  2490
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX4I2__Homo_sapiens__NP_115998

<400>  2490

Met Leu Pro Arg Ala Ala Trp Ser Leu Val Leu Arg Lys Gly Gly Gly 
1               5                   10                  15      


Gly Arg Arg Gly Met His Ser Ser Glu Gly Thr Thr Arg Gly Gly Gly 
            20                  25                  30          


Lys Met Ser Pro Tyr Thr Asn Cys Tyr Ala Gln Arg Tyr Tyr Pro Met 
        35                  40                  45              


Pro Glu Glu Pro Phe Cys Thr Glu Leu Asn Ala Glu Glu Gln Ala Leu 
    50                  55                  60                  


Lys Glu Lys Glu Lys Gly Ser Trp Thr Gln Leu Thr His Ala Glu Lys 
65                  70                  75                  80  


Val Ala Leu Tyr Arg Leu Gln Phe Asn Glu Thr Phe Ala Glu Met Asn 
                85                  90                  95      


Arg Arg Ser Asn Glu Trp Lys Thr Val Met Gly Cys Val Phe Phe Phe 
            100                 105                 110         


Ile Gly Phe Ala Ala Leu Val Ile Trp Trp Gln Arg Val Tyr Val Phe 
        115                 120                 125             


Pro Pro Lys Pro Ile Thr Leu Thr Asp Glu Arg Lys Ala Gln Gln Leu 
    130                 135                 140                 


Gln Arg Met Leu Asp Met Lys Val Asn Pro Val Gln Gly Leu Ala Ser 
145                 150                 155                 160 


Arg Trp Asp Tyr Glu Lys Lys Gln Trp Lys Lys 
                165                 170     


<210>  2491
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX5A__Homo_sapiens__NP_004246

<400>  2491

Met Leu Gly Ala Ala Leu Arg Arg Cys Ala Val Ala Ala Thr Thr Arg 
1               5                   10                  15      


Ala Asp Pro Arg Gly Leu Leu His Ser Ala Arg Thr Pro Gly Pro Ala 
            20                  25                  30          


Val Ala Ile Gln Ser Val Arg Cys Tyr Ser His Gly Ser Gln Glu Thr 
        35                  40                  45              


Asp Glu Glu Phe Asp Ala Arg Trp Val Thr Tyr Phe Asn Lys Pro Asp 
    50                  55                  60                  


Ile Asp Ala Trp Glu Leu Arg Lys Gly Ile Asn Thr Leu Val Thr Tyr 
65                  70                  75                  80  


Asp Met Val Pro Glu Pro Lys Ile Ile Asp Ala Ala Leu Arg Ala Cys 
                85                  90                  95      


Arg Arg Leu Asn Asp Phe Ala Ser Thr Val Arg Ile Leu Glu Val Val 
            100                 105                 110         


Lys Asp Lys Ala Gly Pro His Lys Glu Ile Tyr Pro Tyr Val Ile Gln 
        115                 120                 125             


Glu Leu Arg Pro Thr Leu Asn Glu Leu Gly Ile Ser Thr Pro Glu Glu 
    130                 135                 140                 


Leu Gly Leu Asp Lys Val 
145                 150 


<210>  2492
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX5B__Homo_sapiens__NP_001853

<400>  2492

Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr Leu Ala Ala Gln Ala 
1               5                   10                  15      


Leu Arg Ala Arg Gly Pro Ser Gly Ala Ala Ala Met Arg Ser Met Ala 
            20                  25                  30          


Ser Gly Gly Gly Val Pro Thr Asp Glu Glu Gln Ala Thr Gly Leu Glu 
        35                  40                  45              


Arg Glu Ile Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val 
    50                  55                  60                  


Leu Ala Pro Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val 
65                  70                  75                  80  


Pro Ser Ile Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Glu Glu Asp 
                85                  90                  95      


Asn Thr Ser Val Val Trp Phe Trp Leu His Lys Gly Glu Ala Gln Arg 
            100                 105                 110         


Cys Pro Arg Cys Gly Ala His Tyr Lys Leu Val Pro Gln Gln Leu Ala 
        115                 120                 125             


His 
    


<210>  2493
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX6A1__Homo_sapiens__NP_004364

<400>  2493

Met Ala Val Val Gly Val Ser Ser Val Ser Arg Leu Leu Gly Arg Ser 
1               5                   10                  15      


Arg Pro Gln Leu Gly Arg Pro Met Ser Ser Gly Ala His Gly Glu Glu 
            20                  25                  30          


Gly Ser Ala Arg Met Trp Lys Thr Leu Thr Phe Phe Val Ala Leu Pro 
        35                  40                  45              


Gly Val Ala Val Ser Met Leu Asn Val Tyr Leu Lys Ser His His Gly 
    50                  55                  60                  


Glu His Glu Arg Pro Glu Phe Ile Ala Tyr Pro His Leu Arg Ile Arg 
65                  70                  75                  80  


Thr Lys Pro Phe Pro Trp Gly Asp Gly Asn His Thr Leu Phe His Asn 
                85                  90                  95      


Pro His Val Asn Pro Leu Pro Thr Gly Tyr Glu Asp Glu 
            100                 105                 


<210>  2494
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX6A2__Homo_sapiens__NP_005196

<400>  2494

Met Ala Leu Pro Leu Arg Pro Leu Thr Arg Gly Leu Ala Ser Ala Ala 
1               5                   10                  15      


Lys Gly Gly His Gly Gly Ala Gly Ala Arg Thr Trp Arg Leu Leu Thr 
            20                  25                  30          


Phe Val Leu Ala Leu Pro Ser Val Ala Leu Cys Thr Phe Asn Ser Tyr 
        35                  40                  45              


Leu His Ser Gly His Arg Pro Arg Pro Glu Phe Arg Pro Tyr Gln His 
    50                  55                  60                  


Leu Arg Ile Arg Thr Lys Pro Tyr Pro Trp Gly Asp Gly Asn His Thr 
65                  70                  75                  80  


Leu Phe His Asn Ser His Val Asn Pro Leu Pro Thr Gly Tyr Glu His 
                85                  90                  95      


Pro 
    


<210>  2495
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX6B1__Homo_sapiens__NP_001854

<400>  2495

Met Ala Glu Asp Met Glu Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro 
1               5                   10                  15      


Phe Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Arg Asn Cys Trp Gln 
            20                  25                  30          


Asn Tyr Leu Asp Phe His Arg Cys Gln Lys Ala Met Thr Ala Lys Gly 
        35                  40                  45              


Gly Asp Ile Ser Val Cys Glu Trp Tyr Gln Arg Val Tyr Gln Ser Leu 
    50                  55                  60                  


Cys Pro Thr Ser Trp Val Thr Asp Trp Asp Glu Gln Arg Ala Glu Gly 
65                  70                  75                  80  


Thr Phe Pro Gly Lys Ile 
                85      


<210>  2496
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX6C__Homo_sapiens__NP_004365

<400>  2496

Met Ala Pro Glu Val Leu Pro Lys Pro Arg Met Arg Gly Leu Leu Ala 
1               5                   10                  15      


Arg Arg Leu Arg Asn His Met Ala Val Ala Phe Val Leu Ser Leu Gly 
            20                  25                  30          


Val Ala Ala Leu Tyr Lys Phe Arg Val Ala Asp Gln Arg Lys Lys Ala 
        35                  40                  45              


Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Val Met Lys Asp Phe Glu Glu 
    50                  55                  60                  


Met Arg Lys Ala Gly Ile Phe Gln Ser Val Lys 
65                  70                  75  


<210>  2497
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX7A1__Homo_sapiens__NP_001855

<400>  2497

Met Gln Ala Leu Arg Val Ser Gln Ala Leu Ile Arg Ser Phe Ser Ser 
1               5                   10                  15      


Thr Ala Arg Asn Arg Phe Gln Asn Arg Val Arg Glu Lys Gln Lys Leu 
            20                  25                  30          


Phe Gln Glu Asp Asn Asp Ile Pro Leu Tyr Leu Lys Gly Gly Ile Val 
        35                  40                  45              


Asp Asn Ile Leu Tyr Arg Val Thr Met Thr Leu Cys Leu Gly Gly Thr 
    50                  55                  60                  


Val Tyr Ser Leu Tyr Ser Leu Gly Trp Ala Ser Phe Pro Arg Asn 
65                  70                  75                  


<210>  2498
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX7A2__Homo_sapiens__XP_011533748

<400>  2498

Met His Thr Gln Asp Ser Glu Val Val Pro Val Pro Ala Trp Pro Phe 
1               5                   10                  15      


Ser Leu Val Val Phe Ser Cys Gly Gly Cys Trp Ser Val Thr Ala Lys 
            20                  25                  30          


Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile 
        35                  40                  45              


Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln 
    50                  55                  60                  


Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly 
65                  70                  75                  80  


Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly 
                85                  90                  95      


Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys 
            100                 105                 110         


Lys Gln Glu 
        115 


<210>  2499
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX7A2L__Homo_sapiens__NP_001305965

<400>  2499

Met Tyr Tyr Lys Phe Ser Gly Phe Thr Gln Lys Leu Ala Gly Ala Trp 
1               5                   10                  15      


Ala Ser Glu Ala Tyr Ser Pro Gln Gly Leu Lys Pro Val Val Ser Thr 
            20                  25                  30          


Glu Ala Pro Pro Ile Ile Phe Ala Thr Pro Thr Lys Leu Thr Ser Asp 
        35                  40                  45              


Ser Thr Val Tyr Asp Tyr Ala Gly Lys Asn Lys Val Pro Glu Leu Gln 
    50                  55                  60                  


Lys Phe Phe Gln Lys Ala Asp Gly Val Pro Val Tyr Leu Lys Arg Gly 
65                  70                  75                  80  


Leu Pro Asp Gln Met Leu Tyr Arg Thr Thr Met Ala Leu Thr Val Gly 
                85                  90                  95      


Gly Thr Ile Tyr Cys Leu Ile Ala Leu Tyr Met Ala Ser Gln Pro Lys 
            100                 105                 110         


Asn Lys 
        


<210>  2500
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX7B2__Homo_sapiens__XP_005248113

<400>  2500

Met Met Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln 
1               5                   10                  15      


Ser Ile Leu Gln Ser Met Ala Arg His Ser His Val Lys His Ser Pro 
            20                  25                  30          


Asp Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Thr Ala 
        35                  40                  45              


Phe Cys Val Ala Thr Trp Val Phe Thr Ala Thr Gln Ile Gly Ile Glu 
    50                  55                  60                  


Trp Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Lys His 
65                  70                  75                  80  


Gln 
    


<210>  2501
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX7B__Homo_sapiens__NP_001857

<400>  2501

Met Phe Pro Leu Val Lys Ser Ala Leu Asn Arg Leu Gln Val Arg Ser 
1               5                   10                  15      


Ile Gln Gln Thr Met Ala Arg Gln Ser His Gln Lys Arg Thr Pro Asp 
            20                  25                  30          


Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Ala Thr Phe 
        35                  40                  45              


Cys Ile Val Thr Trp Thr Tyr Val Ala Thr Gln Val Gly Ile Glu Trp 
    50                  55                  60                  


Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Arg Asn Gln 
65                  70                  75                  80  


<210>  2502
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX7C__Homo_sapiens__NP_001858

<400>  2502

Met Leu Gly Gln Ser Ile Arg Arg Phe Thr Thr Ser Val Val Arg Arg 
1               5                   10                  15      


Ser His Tyr Glu Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu 
            20                  25                  30          


Asn Lys Trp Ser Leu Leu Ala Lys Met Cys Leu Tyr Phe Gly Ser Ala 
        35                  40                  45              


Phe Ala Thr Pro Phe Leu Val Val Arg His Gln Leu Leu Lys Thr 
    50                  55                  60              


<210>  2503
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COX8A__Homo_sapiens__NP_004065

<400>  2503

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Pro Pro Glu 
            20                  25                  30          


Gly Lys Leu Gly Ile Met Glu Leu Ala Val Gly Leu Thr Ser Cys Phe 
        35                  40                  45              


Val Thr Phe Leu Leu Pro Ala Gly Trp Ile Leu Ser His Leu Glu Thr 
    50                  55                  60                  


Tyr Arg Arg Pro Glu 
65                  


<210>  2504
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPA1__Homo_sapiens__NP_001859

<400>  2504

Met Arg Gly Leu Leu Val Leu Ser Val Leu Leu Gly Ala Val Phe Gly 
1               5                   10                  15      


Lys Glu Asp Phe Val Gly His Gln Val Leu Arg Ile Ser Val Ala Asp 
            20                  25                  30          


Glu Ala Gln Val Gln Lys Val Lys Glu Leu Glu Asp Leu Glu His Leu 
        35                  40                  45              


Gln Leu Asp Phe Trp Arg Gly Pro Ala His Pro Gly Ser Pro Ile Asp 
    50                  55                  60                  


Val Arg Val Pro Phe Pro Ser Ile Gln Ala Val Lys Ile Phe Leu Glu 
65                  70                  75                  80  


Ser His Gly Ile Ser Tyr Glu Thr Met Ile Glu Asp Val Gln Ser Leu 
                85                  90                  95      


Leu Asp Glu Glu Gln Glu Gln Met Phe Ala Phe Arg Ser Arg Ala Arg 
            100                 105                 110         


Ser Thr Asp Thr Phe Asn Tyr Ala Thr Tyr His Thr Leu Glu Glu Ile 
        115                 120                 125             


Tyr Asp Phe Leu Asp Leu Leu Val Ala Glu Asn Pro His Leu Val Ser 
    130                 135                 140                 


Lys Ile Gln Ile Gly Asn Thr Tyr Glu Gly Arg Pro Ile Tyr Val Leu 
145                 150                 155                 160 


Lys Phe Ser Thr Gly Gly Ser Lys Arg Pro Ala Ile Trp Ile Asp Thr 
                165                 170                 175     


Gly Ile His Ser Arg Glu Trp Val Thr Gln Ala Ser Gly Val Trp Phe 
            180                 185                 190         


Ala Lys Lys Ile Thr Gln Asp Tyr Gly Gln Asp Ala Ala Phe Thr Ala 
        195                 200                 205             


Ile Leu Asp Thr Leu Asp Ile Phe Leu Glu Ile Val Thr Asn Pro Asp 
    210                 215                 220                 


Gly Phe Ala Phe Thr His Ser Thr Asn Arg Met Trp Arg Lys Thr Arg 
225                 230                 235                 240 


Ser His Thr Ala Gly Ser Leu Cys Ile Gly Val Asp Pro Asn Arg Asn 
                245                 250                 255     


Trp Asp Ala Gly Phe Gly Leu Ser Gly Ala Ser Ser Asn Pro Cys Ser 
            260                 265                 270         


Glu Thr Tyr His Gly Lys Phe Ala Asn Ser Glu Val Glu Val Lys Ser 
        275                 280                 285             


Ile Val Asp Phe Val Lys Asp His Gly Asn Ile Lys Ala Phe Ile Ser 
    290                 295                 300                 


Ile His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr Lys Thr 
305                 310                 315                 320 


Glu Pro Val Pro Asp Gln Asp Glu Leu Asp Gln Leu Ser Lys Ala Ala 
                325                 330                 335     


Val Thr Ala Leu Ala Ser Leu Tyr Gly Thr Lys Phe Asn Tyr Gly Ser 
            340                 345                 350         


Ile Ile Lys Ala Ile Tyr Gln Ala Ser Gly Ser Thr Ile Asp Trp Thr 
        355                 360                 365             


Tyr Ser Gln Gly Ile Lys Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr 
    370                 375                 380                 


Gly Arg Tyr Gly Phe Leu Leu Pro Ala Ser Gln Ile Ile Pro Thr Ala 
385                 390                 395                 400 


Lys Glu Thr Trp Leu Ala Leu Leu Thr Ile Met Glu His Thr Leu Asn 
                405                 410                 415     


His Pro Tyr 
            


<210>  2505
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPA2__Homo_sapiens__NP_001860

<400>  2505

Met Ala Met Arg Leu Ile Leu Phe Phe Gly Ala Leu Phe Gly His Ile 
1               5                   10                  15      


Tyr Cys Leu Glu Thr Phe Val Gly Asp Gln Val Leu Glu Ile Val Pro 
            20                  25                  30          


Ser Asn Glu Glu Gln Ile Lys Asn Leu Leu Gln Leu Glu Ala Gln Glu 
        35                  40                  45              


His Leu Gln Leu Asp Phe Trp Lys Ser Pro Thr Thr Pro Gly Glu Thr 
    50                  55                  60                  


Ala His Val Arg Val Pro Phe Val Asn Val Gln Ala Val Lys Val Phe 
65                  70                  75                  80  


Leu Glu Ser Gln Gly Ile Ala Tyr Ser Ile Met Ile Glu Asp Val Gln 
                85                  90                  95      


Val Leu Leu Asp Lys Glu Asn Glu Glu Met Leu Phe Asn Arg Arg Arg 
            100                 105                 110         


Glu Arg Ser Gly Asn Phe Asn Phe Gly Ala Tyr His Thr Leu Glu Glu 
        115                 120                 125             


Ile Ser Gln Glu Met Asp Asn Leu Val Ala Glu His Pro Gly Leu Val 
    130                 135                 140                 


Ser Lys Val Asn Ile Gly Ser Ser Phe Glu Asn Arg Pro Met Asn Val 
145                 150                 155                 160 


Leu Lys Phe Ser Thr Gly Gly Asp Lys Pro Ala Ile Trp Leu Asp Ala 
                165                 170                 175     


Gly Ile His Ala Arg Glu Trp Val Thr Gln Ala Thr Ala Leu Trp Thr 
            180                 185                 190         


Ala Asn Lys Ile Val Ser Asp Tyr Gly Lys Asp Pro Ser Ile Thr Ser 
        195                 200                 205             


Ile Leu Asp Ala Leu Asp Ile Phe Leu Leu Pro Val Thr Asn Pro Asp 
    210                 215                 220                 


Gly Tyr Val Phe Ser Gln Thr Lys Asn Arg Met Trp Arg Lys Thr Arg 
225                 230                 235                 240 


Ser Lys Val Ser Gly Ser Leu Cys Val Gly Val Asp Pro Asn Arg Asn 
                245                 250                 255     


Trp Asp Ala Gly Phe Gly Gly Pro Gly Ala Ser Ser Asn Pro Cys Ser 
            260                 265                 270         


Asp Ser Tyr His Gly Pro Ser Ala Asn Ser Glu Val Glu Val Lys Ser 
        275                 280                 285             


Ile Val Asp Phe Ile Lys Ser His Gly Lys Val Lys Ala Phe Ile Thr 
    290                 295                 300                 


Leu His Ser Tyr Ser Gln Leu Leu Met Phe Pro Tyr Gly Tyr Lys Cys 
305                 310                 315                 320 


Thr Lys Leu Asp Asp Phe Asp Glu Leu Ser Glu Val Ala Gln Lys Ala 
                325                 330                 335     


Ala Gln Ser Leu Arg Ser Leu His Gly Thr Lys Tyr Lys Val Gly Pro 
            340                 345                 350         


Ile Cys Ser Val Ile Tyr Gln Ala Ser Gly Gly Ser Ile Asp Trp Ser 
        355                 360                 365             


Tyr Asp Tyr Gly Ile Lys Tyr Ser Phe Ala Phe Glu Leu Arg Asp Thr 
    370                 375                 380                 


Gly Arg Tyr Gly Phe Leu Leu Pro Ala Arg Gln Ile Leu Pro Thr Ala 
385                 390                 395                 400 


Glu Glu Thr Trp Leu Gly Leu Lys Ala Ile Met Glu His Val Arg Asp 
                405                 410                 415     


His Pro Tyr 
            


<210>  2506
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPA3__Homo_sapiens__NP_001861

<400>  2506

Met Arg Leu Ile Leu Pro Val Gly Leu Ile Ala Thr Thr Leu Ala Ile 
1               5                   10                  15      


Ala Pro Val Arg Phe Asp Arg Glu Lys Val Phe Arg Val Lys Pro Gln 
            20                  25                  30          


Asp Glu Lys Gln Ala Asp Ile Ile Lys Asp Leu Ala Lys Thr Asn Glu 
        35                  40                  45              


Leu Asp Phe Trp Tyr Pro Gly Ala Thr His His Val Ala Ala Asn Met 
    50                  55                  60                  


Met Val Asp Phe Arg Val Ser Glu Lys Glu Ser Gln Ala Ile Gln Ser 
65                  70                  75                  80  


Ala Leu Asp Gln Asn Lys Met His Tyr Glu Ile Leu Ile His Asp Leu 
                85                  90                  95      


Gln Glu Glu Ile Glu Lys Gln Phe Asp Val Lys Glu Asp Ile Pro Gly 
            100                 105                 110         


Arg His Ser Tyr Ala Lys Tyr Asn Asn Trp Glu Lys Ile Val Ala Trp 
        115                 120                 125             


Thr Glu Lys Met Met Asp Lys Tyr Pro Glu Met Val Ser Arg Ile Lys 
    130                 135                 140                 


Ile Gly Ser Thr Val Glu Asp Asn Pro Leu Tyr Val Leu Lys Ile Gly 
145                 150                 155                 160 


Glu Lys Asn Glu Arg Arg Lys Ala Ile Phe Thr Asp Cys Gly Ile His 
                165                 170                 175     


Ala Arg Glu Trp Val Ser Pro Ala Phe Cys Gln Trp Phe Val Tyr Gln 
            180                 185                 190         


Ala Thr Lys Thr Tyr Gly Arg Asn Lys Ile Met Thr Lys Leu Leu Asp 
        195                 200                 205             


Arg Met Asn Phe Tyr Ile Leu Pro Val Phe Asn Val Asp Gly Tyr Ile 
    210                 215                 220                 


Trp Ser Trp Thr Lys Asn Arg Met Trp Arg Lys Asn Arg Ser Lys Asn 
225                 230                 235                 240 


Gln Asn Ser Lys Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala 
                245                 250                 255     


Ser Trp Asn Ser Ile Pro Asn Thr Asn Asp Pro Cys Ala Asp Asn Tyr 
            260                 265                 270         


Arg Gly Ser Ala Pro Glu Ser Glu Lys Glu Thr Lys Ala Val Thr Asn 
        275                 280                 285             


Phe Ile Arg Ser His Leu Asn Glu Ile Lys Val Tyr Ile Thr Phe His 
    290                 295                 300                 


Ser Tyr Ser Gln Met Leu Leu Phe Pro Tyr Gly Tyr Thr Ser Lys Leu 
305                 310                 315                 320 


Pro Pro Asn His Glu Asp Leu Ala Lys Val Ala Lys Ile Gly Thr Asp 
                325                 330                 335     


Val Leu Ser Thr Arg Tyr Glu Thr Arg Tyr Ile Tyr Gly Pro Ile Glu 
            340                 345                 350         


Ser Thr Ile Tyr Pro Ile Ser Gly Ser Ser Leu Asp Trp Ala Tyr Asp 
        355                 360                 365             


Leu Gly Ile Lys His Thr Phe Ala Phe Glu Leu Arg Asp Lys Gly Lys 
    370                 375                 380                 


Phe Gly Phe Leu Leu Pro Glu Ser Arg Ile Lys Pro Thr Cys Arg Glu 
385                 390                 395                 400 


Thr Met Leu Ala Val Lys Phe Ile Ala Lys Tyr Ile Leu Lys His Thr 
                405                 410                 415     


Ser 
    


<210>  2507
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPA4__Homo_sapiens__NP_001156918

<400>  2507

Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys 
1               5                   10                  15      


Gly Gln Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg 
            20                  25                  30          


Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn 
        35                  40                  45              


Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val 
    50                  55                  60                  


Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu 
65                  70                  75                  80  


Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ile 
                85                  90                  95      


Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala Arg 
            100                 105                 110         


Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val Leu 
        115                 120                 125             


Lys Phe Ser Thr Gly Lys Gly Val Arg Arg Pro Ala Val Trp Leu Asn 
    130                 135                 140                 


Ala Gly Ile His Ser Arg Glu Trp Ile Ser Gln Ala Thr Ala Ile Trp 
145                 150                 155                 160 


Thr Ala Arg Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala Ile Thr 
                165                 170                 175     


Ser Ile Leu Glu Lys Met Asp Ile Phe Leu Leu Pro Val Ala Asn Pro 
            180                 185                 190         


Asp Gly Tyr Val Tyr Thr Gln Thr Gln Asn Arg Leu Trp Arg Lys Thr 
        195                 200                 205             


Arg Ser Arg Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn Arg 
    210                 215                 220                 


Asn Trp Asn Ala Ser Phe Ala Gly Lys Gly Ala Ser Asp Asn Pro Cys 
225                 230                 235                 240 


Ser Glu Val Tyr His Gly Pro His Ala Asn Ser Glu Val Glu Val Lys 
                245                 250                 255     


Ser Val Val Asp Phe Ile Gln Lys His Gly Asn Phe Lys Gly Phe Ile 
            260                 265                 270         


Asp Leu His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr Ser 
        275                 280                 285             


Val Lys Lys Ala Pro Asp Ala Glu Glu Leu Asp Lys Val Ala Arg Leu 
    290                 295                 300                 


Ala Ala Lys Ala Leu Ala Ser Val Ser Gly Thr Glu Tyr Gln Val Gly 
305                 310                 315                 320 


Pro Thr Cys Thr Thr Val Tyr Pro Ala Ser Gly Ser Ser Ile Asp Trp 
                325                 330                 335     


Ala Tyr Asp Asn Gly Ile Lys Phe Ala Phe Thr Phe Glu Leu Arg Asp 
            340                 345                 350         


Thr Gly Thr Tyr Gly Phe Leu Leu Pro Ala Asn Gln Ile Ile Pro Thr 
        355                 360                 365             


Ala Glu Glu Thr Trp Leu Gly Leu Lys Thr Ile Met Glu His Val Arg 
    370                 375                 380                 


Asp Asn Leu Tyr 
385             


<210>  2508
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPA6__Homo_sapiens__NP_065094

<400>  2508

Met Lys Cys Leu Gly Lys Arg Arg Gly Gln Ala Ala Ala Phe Leu Pro 
1               5                   10                  15      


Leu Cys Trp Leu Phe Leu Lys Ile Leu Gln Pro Gly His Ser His Leu 
            20                  25                  30          


Tyr Asn Asn Arg Tyr Ala Gly Asp Lys Val Ile Arg Phe Ile Pro Lys 
        35                  40                  45              


Thr Glu Glu Glu Ala Tyr Ala Leu Lys Lys Ile Ser Tyr Gln Leu Lys 
    50                  55                  60                  


Val Asp Leu Trp Gln Pro Ser Ser Ile Ser Tyr Val Ser Glu Gly Thr 
65                  70                  75                  80  


Val Thr Asp Val His Ile Pro Gln Asn Gly Ser Arg Ala Leu Leu Ala 
                85                  90                  95      


Phe Leu Gln Glu Ala Asn Ile Gln Tyr Lys Val Leu Ile Glu Asp Leu 
            100                 105                 110         


Gln Lys Thr Leu Glu Lys Gly Ser Ser Leu His Thr Gln Arg Asn Arg 
        115                 120                 125             


Arg Ser Leu Ser Gly Tyr Asn Tyr Glu Val Tyr His Ser Leu Glu Glu 
    130                 135                 140                 


Ile Gln Asn Trp Met His His Leu Asn Lys Thr His Ser Gly Leu Ile 
145                 150                 155                 160 


His Met Phe Ser Ile Gly Arg Ser Tyr Glu Gly Arg Ser Leu Phe Ile 
                165                 170                 175     


Leu Lys Leu Gly Arg Arg Ser Arg Leu Lys Arg Ala Val Trp Ile Asp 
            180                 185                 190         


Cys Gly Ile His Ala Arg Glu Trp Ile Gly Pro Ala Phe Cys Gln Trp 
        195                 200                 205             


Phe Val Lys Glu Ala Leu Leu Thr Tyr Lys Ser Asp Pro Ala Met Arg 
    210                 215                 220                 


Lys Met Leu Asn His Leu Tyr Phe Tyr Ile Met Pro Val Phe Asn Val 
225                 230                 235                 240 


Asp Gly Tyr His Phe Ser Trp Thr Asn Asp Arg Phe Trp Arg Lys Thr 
                245                 250                 255     


Arg Ser Arg Asn Ser Arg Phe Arg Cys Arg Gly Val Asp Ala Asn Arg 
            260                 265                 270         


Asn Trp Lys Val Lys Trp Cys Asp Glu Gly Ala Ser Met His Pro Cys 
        275                 280                 285             


Asp Asp Thr Tyr Cys Gly Pro Phe Pro Glu Ser Glu Pro Glu Val Lys 
    290                 295                 300                 


Ala Val Ala Asn Phe Leu Arg Lys His Arg Lys His Ile Arg Ala Tyr 
305                 310                 315                 320 


Leu Ser Phe His Ala Tyr Ala Gln Met Leu Leu Tyr Pro Tyr Ser Tyr 
                325                 330                 335     


Lys Tyr Ala Thr Ile Pro Asn Phe Arg Cys Val Glu Ser Ala Ala Tyr 
            340                 345                 350         


Lys Ala Val Asn Ala Leu Gln Ser Val Tyr Gly Val Arg Tyr Arg Tyr 
        355                 360                 365             


Gly Pro Ala Ser Thr Thr Leu Tyr Val Ser Ser Gly Ser Ser Met Asp 
    370                 375                 380                 


Trp Ala Tyr Lys Asn Gly Ile Pro Tyr Ala Phe Ala Phe Glu Leu Arg 
385                 390                 395                 400 


Asp Thr Gly Tyr Phe Gly Phe Leu Leu Pro Glu Met Leu Ile Lys Pro 
                405                 410                 415     


Thr Cys Thr Glu Thr Met Leu Ala Val Lys Asn Ile Thr Met His Leu 
            420                 425                 430         


Leu Lys Lys Cys Pro 
        435         


<210>  2509
<211>  1932
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPAMD8__Homo_sapiens__NP_056507

<400>  2509

Met Ala Pro Gly Ala Leu Arg Gly Gly Cys Glu Gln Arg Ala Pro Gly 
1               5                   10                  15      


Gly Gly Ala Arg Thr Ala Ala Leu Gly Pro Trp Pro Trp Pro Ser Pro 
            20                  25                  30          


Gly Pro Ala Pro Ser Pro Gly Ala Ala Pro Pro Arg Ser Arg Lys Met 
        35                  40                  45              


Ser Gly Ala Leu Leu Trp Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu 
    50                  55                  60                  


Ser Ala Arg Asp Gly Val Arg Ala Ala Gln Pro Gln Ala Pro Gly Tyr 
65                  70                  75                  80  


Leu Ile Ala Ala Pro Ser Val Phe Arg Ala Gly Val Glu Glu Val Ile 
                85                  90                  95      


Ser Val Thr Ile Phe Asn Ser Pro Arg Glu Val Thr Val Gln Ala Gln 
            100                 105                 110         


Leu Val Ala Gln Gly Glu Pro Val Val Gln Ser Gln Gly Ala Ile Leu 
        115                 120                 125             


Asp Lys Gly Thr Ile Lys Leu Lys Val Pro Thr Gly Leu Arg Gly Gln 
    130                 135                 140                 


Ala Leu Leu Lys Val Trp Gly Arg Gly Trp Gln Ala Glu Glu Gly Pro 
145                 150                 155                 160 


Leu Phe His Asn Gln Thr Ser Val Thr Val Asp Gly Arg Gly Ala Ser 
                165                 170                 175     


Val Phe Ile Gln Thr Asp Lys Pro Val Tyr Arg Pro Gln His Arg Val 
            180                 185                 190         


Leu Ile Ser Ile Phe Thr Val Ser Pro Asn Leu Arg Pro Val Asn Glu 
        195                 200                 205             


Lys Leu Glu Ala Tyr Ile Leu Asp Pro Arg Gly Ser Arg Met Ile Glu 
    210                 215                 220                 


Trp Arg His Leu Lys Pro Phe Cys Cys Gly Ile Thr Asn Met Ser Phe 
225                 230                 235                 240 


Pro Leu Ser Asp Gln Pro Val Leu Gly Glu Trp Phe Ile Phe Val Glu 
                245                 250                 255     


Met Gln Gly His Ala Tyr Asn Lys Ser Phe Glu Val Gln Lys Tyr Val 
            260                 265                 270         


Leu Pro Lys Phe Glu Leu Leu Ile Asp Pro Pro Arg Tyr Ile Gln Asp 
        275                 280                 285             


Leu Asp Ala Cys Glu Thr Gly Thr Val Arg Ala Arg Tyr Thr Phe Gly 
    290                 295                 300                 


Lys Pro Val Ala Gly Ala Leu Met Ile Asn Met Thr Val Asn Gly Val 
305                 310                 315                 320 


Gly Tyr Tyr Ser His Glu Val Gly Arg Pro Val Leu Arg Thr Thr Lys 
                325                 330                 335     


Ile Leu Gly Ser Arg Asp Phe Asp Ile Cys Val Arg Asp Met Ile Pro 
            340                 345                 350         


Ala Asp Val Pro Glu His Phe Arg Gly Arg Val Ser Ile Trp Ala Met 
        355                 360                 365             


Val Thr Ser Val Asp Gly Ser Gln Gln Val Ala Phe Asp Asp Ser Thr 
    370                 375                 380                 


Pro Val Gln Arg Gln Leu Val Asp Ile Arg Tyr Ser Lys Asp Thr Arg 
385                 390                 395                 400 


Lys Gln Phe Lys Pro Gly Leu Ala Tyr Val Gly Lys Val Glu Leu Ser 
                405                 410                 415     


Tyr Pro Asp Gly Ser Pro Ala Glu Gly Val Thr Val Gln Ile Lys Ala 
            420                 425                 430         


Glu Leu Thr Pro Lys Asp Asn Ile Tyr Thr Ser Glu Val Val Ser Gln 
        435                 440                 445             


Arg Gly Leu Val Gly Phe Glu Ile Pro Ser Ile Pro Thr Ser Ala Gln 
    450                 455                 460                 


His Val Trp Leu Glu Thr Lys Val Met Ala Leu Asn Gly Lys Pro Val 
465                 470                 475                 480 


Gly Ala Gln Tyr Leu Pro Ser Tyr Leu Ser Leu Gly Ser Trp Tyr Ser 
                485                 490                 495     


Pro Ser Gln Cys Tyr Leu Gln Leu Gln Pro Pro Ser His Pro Leu Gln 
            500                 505                 510         


Val Gly Glu Glu Ala Tyr Phe Ser Val Lys Ser Thr Cys Pro Cys Asn 
        515                 520                 525             


Phe Thr Leu Tyr Tyr Glu Val Ala Ala Arg Gly Asn Ile Val Leu Ser 
    530                 535                 540                 


Gly Gln Gln Pro Ala His Thr Thr Gln Gln Arg Ser Lys Arg Ala Ala 
545                 550                 555                 560 


Pro Ala Leu Glu Lys Pro Ile Arg Leu Thr His Leu Ser Glu Thr Glu 
                565                 570                 575     


Pro Pro Pro Ala Pro Glu Ala Glu Val Asp Val Cys Val Thr Ser Leu 
            580                 585                 590         


His Leu Ala Val Thr Pro Ser Met Val Pro Leu Gly Arg Leu Leu Val 
        595                 600                 605             


Phe Tyr Val Arg Glu Asn Gly Glu Gly Val Ala Asp Ser Leu Gln Phe 
    610                 615                 620                 


Ala Val Glu Thr Phe Phe Glu Asn Gln Val Ser Val Thr Tyr Ser Ala 
625                 630                 635                 640 


Asn Glu Thr Gln Pro Gly Glu Val Val Asp Leu Arg Ile Arg Ala Ala 
                645                 650                 655     


Arg Gly Ser Cys Val Cys Val Ala Ala Val Asp Lys Ser Val Tyr Leu 
            660                 665                 670         


Leu Arg Ser Gly Phe Arg Leu Thr Pro Ala Gln Val Phe Gln Glu Leu 
        675                 680                 685             


Glu Asp Tyr Asp Val Ser Asp Ser Phe Gly Val Ser Arg Glu Asp Gly 
    690                 695                 700                 


Pro Phe Trp Trp Ala Gly Leu Thr Ala Gln Arg Arg Arg Arg Ser Ser 
705                 710                 715                 720 


Val Phe Pro Trp Pro Trp Gly Ile Thr Lys Asp Ser Gly Phe Ala Phe 
                725                 730                 735     


Thr Glu Thr Gly Leu Val Val Met Thr Asp Arg Val Ser Leu Asn His 
            740                 745                 750         


Arg Gln Asp Gly Gly Leu Tyr Thr Asp Glu Ala Val Pro Ala Phe Gln 
        755                 760                 765             


Pro His Thr Gly Ser Leu Val Ala Val Ala Pro Ser Arg His Pro Pro 
    770                 775                 780                 


Arg Thr Glu Lys Arg Lys Arg Thr Phe Phe Pro Glu Thr Trp Ile Trp 
785                 790                 795                 800 


His Cys Leu Asn Ile Ser Asp Pro Ser Gly Glu Gly Thr Leu Ser Val 
                805                 810                 815     


Lys Val Pro Asp Ser Ile Thr Ser Trp Val Gly Glu Ala Val Ala Leu 
            820                 825                 830         


Ser Thr Ser Gln Gly Leu Gly Ile Ala Glu Pro Ser Leu Leu Lys Thr 
        835                 840                 845             


Phe Lys Pro Phe Phe Val Asp Phe Met Leu Pro Ala Leu Ile Ile Arg 
    850                 855                 860                 


Gly Glu Gln Val Lys Ile Pro Leu Ser Val Tyr Asn Tyr Met Gly Thr 
865                 870                 875                 880 


Cys Ala Glu Val Tyr Met Lys Leu Ser Val Pro Lys Gly Ile Gln Phe 
                885                 890                 895     


Val Gly His Pro Gly Lys Arg His Val Thr Lys Lys Met Cys Val Ala 
            900                 905                 910         


Pro Gly Glu Ala Glu Pro Ile Trp Val Val Leu Ser Phe Ser Asp Leu 
        915                 920                 925             


Gly Leu Asn Asn Ile Thr Ala Lys Ala Leu Ala Tyr Gly Asp Thr Asn 
    930                 935                 940                 


Cys Cys Arg Asp Gly Arg Ser Ser Lys His Pro Glu Glu Asn His Ala 
945                 950                 955                 960 


Asp Arg Arg Val Pro Ile Gly Val Asp His Val Arg Arg Ser Val Met 
                965                 970                 975     


Val Glu Ala Glu Gly Val Pro Arg Ala Tyr Thr Tyr Ser Ala Phe Phe 
            980                 985                 990         


Cys Pro Ser Glu Arg Val His Ile  Ser Thr Pro Asn Lys  Tyr Glu Phe 
        995                 1000                 1005             


Gln Tyr  Val Gln Arg Pro Leu  Arg Leu Thr Arg Phe  Asp Val Ala 
    1010                 1015                 1020             


Val Arg  Ala His Asn Asp Ala  Arg Val Ala Leu Ser  Ser Gly Pro 
    1025                 1030                 1035             


Gln Asp  Thr Ala Gly Met Ile  Glu Ile Val Leu Gly  Gly His Gln 
    1040                 1045                 1050             


Asn Thr  Arg Ser Trp Ile Ser  Thr Ser Lys Met Gly  Glu Pro Val 
    1055                 1060                 1065             


Ala Ser  Ala His Thr Ala Lys  Ile Leu Ser Trp Asp  Glu Phe Arg 
    1070                 1075                 1080             


Thr Phe  Trp Ile Ser Trp Arg  Gly Gly Leu Ile Gln  Val Gly His 
    1085                 1090                 1095             


Gly Pro  Glu Pro Ser Asn Glu  Ser Val Ile Val Ala  Trp Thr Leu 
    1100                 1105                 1110             


Pro Arg  Pro Pro Glu Val Gln  Phe Ile Gly Phe Ser  Thr Gly Trp 
    1115                 1120                 1125             


Gly Ser  Met Gly Glu Phe Arg  Ile Trp Arg Lys Met  Glu Val Asp 
    1130                 1135                 1140             


Glu Ser  Tyr Ser Glu Ala Phe  Thr Leu Gly Val Pro  His Gly Ala 
    1145                 1150                 1155             


Ile Pro  Gly Ser Glu Arg Ala  Thr Ala Ser Ile Ile  Gly Asp Val 
    1160                 1165                 1170             


Met Gly  Pro Thr Leu Asn His  Leu Asn Asn Leu Leu  Arg Leu Pro 
    1175                 1180                 1185             


Phe Gly  Cys Gly Glu Gln Asn  Met Ile His Phe Ala  Pro Asn Val 
    1190                 1195                 1200             


Phe Val  Leu Lys Tyr Leu Gln  Lys Thr Gln Gln Leu  Ser Pro Glu 
    1205                 1210                 1215             


Val Glu  Arg Glu Thr Thr Asp  Tyr Leu Val Gln Gly  Tyr Gln Arg 
    1220                 1225                 1230             


Gln Leu  Thr Tyr Lys Arg Gln  Asp Gly Ser Tyr Ser  Ala Phe Gly 
    1235                 1240                 1245             


Glu Arg  Asp Ala Ser Gly Ser  Met Trp Leu Thr Ala  Phe Val Leu 
    1250                 1255                 1260             


Lys Ser  Phe Ala Gln Ala Arg  Ser Phe Ile Phe Val  Asp Pro Arg 
    1265                 1270                 1275             


Glu Leu  Ala Ala Ala Lys Ser  Trp Ile Ile Gln Gln  Gln Gln Ala 
    1280                 1285                 1290             


Asp Gly  Ser Phe Leu Ala Val  Gly Arg Val Leu Asn  Lys Asp Ile 
    1295                 1300                 1305             


Gln Gly  Gly Ile His Gly Thr  Val Pro Leu Thr Ala  Tyr Val Val 
    1310                 1315                 1320             


Val Ala  Leu Leu Glu Thr Gly  Thr Ala Ser Glu Glu  Glu Arg Gly 
    1325                 1330                 1335             


Ser Thr  Asp Lys Ala Arg His  Phe Leu Glu Ser Ala  Ala Pro Leu 
    1340                 1345                 1350             


Ala Met  Asp Pro Tyr Ser Cys  Ala Leu Thr Thr Tyr  Ala Leu Thr 
    1355                 1360                 1365             


Leu Leu  Arg Ser Pro Ala Ala  Pro Glu Ala Leu Arg  Lys Leu Arg 
    1370                 1375                 1380             


Ser Leu  Ala Ile Met Arg Asp  Gly Val Thr His Trp  Ser Leu Ser 
    1385                 1390                 1395             


Asn Ser  Trp Asp Val Asp Lys  Gly Thr Phe Leu Ser  Phe Ser Asp 
    1400                 1405                 1410             


Arg Val  Ser Gln Ser Val Val  Ser Ala Glu Val Glu  Met Thr Ala 
    1415                 1420                 1425             


Tyr Ala  Leu Leu Thr Tyr Thr  Leu Leu Gly Asp Val  Ala Ala Ala 
    1430                 1435                 1440             


Leu Pro  Val Val Lys Trp Leu  Ser Gln Gln Arg Asn  Ala Leu Gly 
    1445                 1450                 1455             


Gly Phe  Ser Ser Thr Gln Asp  Thr Cys Val Ala Leu  Gln Ala Leu 
    1460                 1465                 1470             


Ala Glu  Tyr Ala Ile Leu Ser  Tyr Ala Gly Gly Ile  Asn Leu Thr 
    1475                 1480                 1485             


Val Ser  Leu Ala Ser Thr Asn  Leu Asp Tyr Gln Glu  Thr Phe Glu 
    1490                 1495                 1500             


Leu His  Arg Thr Asn Gln Lys  Val Leu Gln Thr Ala  Ala Ile Pro 
    1505                 1510                 1515             


Ser Leu  Pro Thr Gly Leu Phe  Val Ser Ala Lys Gly  Asp Gly Cys 
    1520                 1525                 1530             


Cys Leu  Met Gln Ile Asp Val  Thr Tyr Asn Val Pro  Asp Pro Val 
    1535                 1540                 1545             


Ala Lys  Pro Ala Phe Gln Leu  Leu Val Ser Leu Gln  Glu Pro Glu 
    1550                 1555                 1560             


Ala Gln  Gly Arg Pro Pro Pro  Met Pro Ala Ser Ala  Ala Glu Gly 
    1565                 1570                 1575             


Ser Arg  Gly Asp Trp Pro Pro  Ala Asp Asp Asp Asp  Pro Ala Ala 
    1580                 1585                 1590             


Asp Gln  His His Gln Glu Tyr  Lys Val Met Leu Glu  Val Cys Thr 
    1595                 1600                 1605             


Arg Trp  Leu His Ala Gly Ser  Ser Asn Met Ala Val  Leu Glu Val 
    1610                 1615                 1620             


Pro Leu  Leu Ser Gly Phe Arg  Ala Asp Ile Glu Ser  Leu Glu Gln 
    1625                 1630                 1635             


Leu Leu  Leu Asp Lys His Met  Gly Met Lys Arg Tyr  Glu Val Ala 
    1640                 1645                 1650             


Gly Arg  Arg Val Leu Phe Tyr  Phe Asp Glu Ile Pro  Ser Arg Cys 
    1655                 1660                 1665             


Leu Thr  Cys Val Arg Phe Arg  Ala Leu Arg Glu Cys  Val Val Gly 
    1670                 1675                 1680             


Arg Thr  Ser Ala Leu Pro Val  Ser Val Tyr Asp Tyr  Tyr Glu Pro 
    1685                 1690                 1695             


Ala Phe  Glu Ala Thr Arg Phe  Tyr Asn Val Ser Thr  His Ser Pro 
    1700                 1705                 1710             


Leu Ala  Arg Glu Leu Cys Ala  Gly Pro Ala Cys Asn  Glu Val Glu 
    1715                 1720                 1725             


Arg Ala  Pro Ala Arg Gly Pro  Gly Trp Phe Pro Gly  Glu Ser Gly 
    1730                 1735                 1740             


Pro Ala  Val Ala Pro Glu Glu  Gly Ala Ala Ile Ala  Arg Cys Gly 
    1745                 1750                 1755             


Cys Asp  His Asp Cys Gly Ala  Gln Gly Asn Pro Val  Cys Gly Ser 
    1760                 1765                 1770             


Asp Gly  Val Val Tyr Ala Ser  Ala Cys Arg Leu Arg  Glu Ala Ala 
    1775                 1780                 1785             


Cys Arg  Gln Ala Ala Pro Leu  Glu Pro Ala Pro Pro  Ser Cys Cys 
    1790                 1795                 1800             


Ala Leu  Glu Gln Arg Leu Pro  Ala Ser Ser Ser Ser  Thr Tyr Gly 
    1805                 1810                 1815             


Asp Asp  Leu Ala Ser Val Ala  Pro Gly Pro Leu Gln  Gln Asp Val 
    1820                 1825                 1830             


Lys Leu  Asn Gly Ala Gly Leu  Glu Val Glu Asp Ser  Asp Pro Glu 
    1835                 1840                 1845             


Pro Glu  Gly Glu Ala Glu Asp  Arg Val Thr Ala Gly  Pro Arg Pro 
    1850                 1855                 1860             


Pro Val  Ser Ser Gly Asn Leu  Glu Ser Ser Thr Gln  Ser Ala Ser 
    1865                 1870                 1875             


Pro Phe  His Arg Trp Gly Gln  Thr Pro Ala Pro Gln  Arg His Ser 
    1880                 1885                 1890             


Gly Arg  Val Val Gly Ala His  Arg Pro Gly Leu Leu  Ser Pro Val 
    1895                 1900                 1905             


Phe Val  Tyr Ser Pro Ala Phe  Gln Ser Gly Gly Glu  Glu Gly Leu 
    1910                 1915                 1920             


Trp Met  Ser Asn Thr Cys Thr  Leu Arg 
    1925                 1930         


<210>  2510
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPB1__Homo_sapiens__NP_001862

<400>  2510

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His 
1               5                   10                  15      


His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val 
            20                  25                  30          


Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr 
        35                  40                  45              


Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr Gln Ile Lys Pro His 
    50                  55                  60                  


Ser Thr Val Asp Phe Arg Val Lys Ala Glu Asp Thr Val Thr Val Glu 
65                  70                  75                  80  


Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr Lys Val Leu Ile Ser Asn 
                85                  90                  95      


Leu Arg Asn Val Val Glu Ala Gln Phe Asp Ser Arg Val Arg Ala Thr 
            100                 105                 110         


Gly His Ser Tyr Glu Lys Tyr Asn Lys Trp Glu Thr Ile Glu Ala Trp 
        115                 120                 125             


Thr Gln Gln Val Ala Thr Glu Asn Pro Ala Leu Ile Ser Arg Ser Val 
    130                 135                 140                 


Ile Gly Thr Thr Phe Glu Gly Arg Ala Ile Tyr Leu Leu Lys Val Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Asn Lys Pro Ala Ile Phe Met Asp Cys Gly Phe His 
                165                 170                 175     


Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Gln Trp Phe Val Arg Glu 
            180                 185                 190         


Ala Val Arg Thr Tyr Gly Arg Glu Ile Gln Val Thr Glu Leu Leu Asp 
        195                 200                 205             


Lys Leu Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile 
    210                 215                 220                 


Tyr Thr Trp Thr Lys Ser Arg Phe Trp Arg Lys Thr Arg Ser Thr His 
225                 230                 235                 240 


Thr Gly Ser Ser Cys Ile Gly Thr Asp Pro Asn Arg Asn Phe Asp Ala 
                245                 250                 255     


Gly Trp Cys Glu Ile Gly Ala Ser Arg Asn Pro Cys Asp Glu Thr Tyr 
            260                 265                 270         


Cys Gly Pro Ala Ala Glu Ser Glu Lys Glu Thr Lys Ala Leu Ala Asp 
        275                 280                 285             


Phe Ile Arg Asn Lys Leu Ser Ser Ile Lys Ala Tyr Leu Thr Ile His 
    290                 295                 300                 


Ser Tyr Ser Gln Met Met Ile Tyr Pro Tyr Ser Tyr Ala Tyr Lys Leu 
305                 310                 315                 320 


Gly Glu Asn Asn Ala Glu Leu Asn Ala Leu Ala Lys Ala Thr Val Lys 
                325                 330                 335     


Glu Leu Ala Ser Leu His Gly Thr Lys Tyr Thr Tyr Gly Pro Gly Ala 
            340                 345                 350         


Thr Thr Ile Tyr Pro Ala Ala Gly Gly Ser Asp Asp Trp Ala Tyr Asp 
        355                 360                 365             


Gln Gly Ile Arg Tyr Ser Phe Thr Phe Glu Leu Arg Asp Thr Gly Arg 
    370                 375                 380                 


Tyr Gly Phe Leu Leu Pro Glu Ser Gln Ile Arg Ala Thr Cys Glu Glu 
385                 390                 395                 400 


Thr Phe Leu Ala Ile Lys Tyr Val Ala Ser Tyr Val Leu Glu His Leu 
                405                 410                 415     


Tyr 
    


<210>  2511
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPB2__Homo_sapiens__NP_001265470

<400>  2511

Met Lys Leu Cys Ser Leu Ala Val Leu Val Pro Ile Val Leu Phe Cys 
1               5                   10                  15      


Glu Gln His Val Phe Ala Phe Gln Ser Gly Gln Val Leu Ala Ala Leu 
            20                  25                  30          


Pro Arg Thr Ser Arg Gln Val Gln Val Leu Gln Asn Leu Thr Thr Thr 
        35                  40                  45              


Tyr Glu Ile Val Leu Trp Gln Pro Val Thr Ala Asp Leu Ile Val Lys 
    50                  55                  60                  


Lys Lys Gln Val His Phe Phe Val Asn Ala Ser Asp Val Asp Asn Val 
65                  70                  75                  80  


Lys Ala His Leu Asn Val Ser Gly Ile Pro Cys Ser Val Leu Leu Ala 
                85                  90                  95      


Asp Val Glu Asp Leu Ile Gln Gln Gln Ile Ser Asn Asp Thr Val Ser 
            100                 105                 110         


Pro Arg Ala Ser Ala Ser Tyr Tyr Glu Gln Tyr His Ser Leu Asn Glu 
        115                 120                 125             


Ile Tyr Ser Trp Ile Glu Phe Ile Thr Glu Arg His Pro Asp Met Leu 
    130                 135                 140                 


Thr Lys Ile His Ile Gly Ser Ser Phe Glu Lys Tyr Pro Leu Tyr Val 
145                 150                 155                 160 


Leu Lys Val Ser Gly Lys Glu Gln Ala Ala Lys Asn Ala Ile Trp Ile 
                165                 170                 175     


Asp Cys Gly Ile His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Leu 
            180                 185                 190         


Trp Phe Ile Gly His Asn Arg Met Trp Arg Lys Asn Arg Ser Phe Tyr 
        195                 200                 205             


Ala Asn Asn His Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Ala Ser 
    210                 215                 220                 


Lys His Trp Cys Glu Glu Gly Ala Ser Ser Ser Ser Cys Ser Glu Thr 
225                 230                 235                 240 


Tyr Cys Gly Leu Tyr Pro Glu Ser Glu Pro Glu Val Lys Ala Val Ala 
                245                 250                 255     


Ser Phe Leu Arg Arg Asn Ile Asn Gln Ile Lys Ala Tyr Ile Ser Met 
            260                 265                 270         


His Ser Tyr Ser Gln His Ile Val Phe Pro Tyr Ser Tyr Thr Arg Ser 
        275                 280                 285             


Lys Ser Lys Asp His Glu Glu Leu Ser Leu Val Ala Ser Glu Ala Val 
    290                 295                 300                 


Arg Ala Ile Glu Lys Ile Ser Lys Asn Thr Arg Tyr Thr His Gly His 
305                 310                 315                 320 


Gly Ser Glu Thr Leu Tyr Leu Ala Pro Gly Gly Gly Asp Asp Trp Ile 
                325                 330                 335     


Tyr Asp Leu Gly Ile Lys Tyr Ser Phe Thr Ile Glu Leu Arg Asp Thr 
            340                 345                 350         


Gly Thr Tyr Gly Phe Leu Leu Pro Glu Arg Tyr Ile Lys Pro Thr Cys 
        355                 360                 365             


Arg Glu Ala Phe Ala Ala Val Ser Lys Ile Ala Trp His Val Ile Arg 
    370                 375                 380                 


Asn Val 
385     


<210>  2512
<211>  1133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPD__Homo_sapiens__NP_001186704

<400>  2512

Met Arg Phe Val Leu Ser Gly Asn Leu His Gly Gly Ser Val Val Ala 
1               5                   10                  15      


Ser Tyr Pro Phe Asp Asp Ser Pro Glu His Lys Ala Thr Gly Ile Tyr 
            20                  25                  30          


Ser Lys Thr Ser Asp Asp Glu Val Phe Lys Tyr Leu Ala Lys Ala Tyr 
        35                  40                  45              


Ala Ser Asn His Pro Ile Met Lys Thr Gly Glu Pro His Cys Pro Gly 
    50                  55                  60                  


Asp Glu Asp Glu Thr Phe Lys Asp Gly Ile Thr Asn Gly Ala His Trp 
65                  70                  75                  80  


Tyr Asp Val Glu Gly Gly Met Gln Asp Tyr Asn Tyr Val Trp Ala Asn 
                85                  90                  95      


Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro Pro Ala 
            100                 105                 110         


Ser Gln Leu Arg Gln Glu Trp Glu Asn Asn Arg Glu Ser Leu Ile Thr 
        115                 120                 125             


Leu Ile Glu Lys Val His Ile Gly Val Lys Gly Phe Val Lys Asp Ser 
    130                 135                 140                 


Ile Thr Gly Ser Gly Leu Glu Asn Ala Thr Ile Ser Val Ala Gly Ile 
145                 150                 155                 160 


Asn His Asn Ile Thr Thr Gly Arg Phe Gly Asp Phe Tyr Arg Leu Leu 
                165                 170                 175     


Val Pro Gly Thr Tyr Asn Leu Thr Val Val Leu Thr Gly Tyr Met Pro 
            180                 185                 190         


Leu Thr Val Thr Asn Val Val Val Lys Glu Gly Pro Ala Thr Glu Val 
        195                 200                 205             


Asp Phe Ser Leu Arg Pro Thr Val Thr Ser Val Ile Pro Asp Thr Thr 
    210                 215                 220                 


Glu Ala Val Ser Thr Ala Ser Thr Val Ala Ile Pro Asn Ile Leu Ser 
225                 230                 235                 240 


Gly Thr Ser Ser Ser Tyr Gln Pro Ile Gln Pro Lys Asp Phe His His 
                245                 250                 255     


His His Phe Pro Asp Met Glu Ile Phe Leu Arg Arg Phe Ala Asn Glu 
            260                 265                 270         


Tyr Pro Asn Ile Thr Arg Leu Tyr Ser Leu Gly Lys Ser Val Glu Ser 
        275                 280                 285             


Arg Glu Leu Tyr Val Met Glu Ile Ser Asp Asn Pro Gly Val His Glu 
    290                 295                 300                 


Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn Met His Gly Asn Glu 
305                 310                 315                 320 


Val Val Gly Arg Glu Leu Leu Leu Asn Leu Ile Glu Tyr Leu Cys Lys 
                325                 330                 335     


Asn Phe Gly Thr Asp Pro Glu Val Thr Asp Leu Val His Asn Thr Arg 
            340                 345                 350         


Ile His Leu Met Pro Ser Met Asn Pro Asp Gly Tyr Glu Lys Ser Gln 
        355                 360                 365             


Glu Gly Asp Ser Ile Ser Val Ile Gly Arg Asn Asn Ser Asn Asn Phe 
    370                 375                 380                 


Asp Leu Asn Arg Asn Phe Pro Asp Gln Phe Val Gln Ile Thr Asp Pro 
385                 390                 395                 400 


Thr Gln Pro Glu Thr Ile Ala Val Met Ser Trp Met Lys Ser Tyr Pro 
                405                 410                 415     


Phe Val Leu Ser Ala Asn Leu His Gly Gly Ser Leu Val Val Asn Tyr 
            420                 425                 430         


Pro Phe Asp Asp Asp Glu Gln Gly Leu Ala Thr Tyr Ser Lys Ser Pro 
        435                 440                 445             


Asp Asp Ala Val Phe Gln Gln Ile Ala Leu Ser Tyr Ser Lys Glu Asn 
    450                 455                 460                 


Ser Gln Met Phe Gln Gly Arg Pro Cys Lys Asn Met Tyr Pro Asn Glu 
465                 470                 475                 480 


Tyr Phe Pro His Gly Ile Thr Asn Gly Ala Ser Trp Tyr Asn Val Pro 
                485                 490                 495     


Gly Gly Met Gln Asp Trp Asn Tyr Leu Gln Thr Asn Cys Phe Glu Val 
            500                 505                 510         


Thr Ile Glu Leu Gly Cys Val Lys Tyr Pro Leu Glu Lys Glu Leu Pro 
        515                 520                 525             


Asn Phe Trp Glu Gln Asn Arg Arg Ser Leu Ile Gln Phe Met Lys Gln 
    530                 535                 540                 


Val His Gln Gly Val Arg Gly Phe Val Leu Asp Ala Thr Asp Gly Arg 
545                 550                 555                 560 


Gly Ile Leu Asn Ala Thr Ile Ser Val Ala Glu Ile Asn His Pro Val 
                565                 570                 575     


Thr Thr Tyr Lys Thr Gly Asp Tyr Trp Arg Leu Leu Val Pro Gly Thr 
            580                 585                 590         


Tyr Lys Ile Thr Ala Ser Ala Arg Gly Tyr Asn Pro Val Thr Lys Asn 
        595                 600                 605             


Val Thr Val Lys Ser Glu Gly Ala Ile Gln Val Asn Phe Thr Leu Val 
    610                 615                 620                 


Arg Ser Ser Thr Asp Ser Asn Asn Glu Ser Lys Lys Gly Lys Gly Ala 
625                 630                 635                 640 


Ser Ser Ser Thr Asn Asp Ala Ser Asp Pro Thr Thr Lys Glu Phe Glu 
                645                 650                 655     


Thr Leu Ile Lys Asp Leu Ser Ala Glu Asn Gly Leu Glu Ser Leu Met 
            660                 665                 670         


Leu Arg Ser Ser Ser Asn Leu Ala Leu Ala Leu Tyr Arg Tyr His Ser 
        675                 680                 685             


Tyr Lys Asp Leu Ser Glu Phe Leu Arg Gly Leu Val Met Asn Tyr Pro 
    690                 695                 700                 


His Ile Thr Asn Leu Thr Asn Leu Gly Gln Ser Thr Glu Tyr Arg His 
705                 710                 715                 720 


Ile Trp Ser Leu Glu Ile Ser Asn Lys Pro Asn Val Ser Glu Pro Glu 
                725                 730                 735     


Glu Pro Lys Ile Arg Phe Val Ala Gly Ile His Gly Asn Ala Pro Val 
            740                 745                 750         


Gly Thr Glu Leu Leu Leu Ala Leu Ala Glu Phe Leu Cys Leu Asn Tyr 
        755                 760                 765             


Lys Lys Asn Pro Ala Val Thr Gln Leu Val Asp Arg Thr Arg Ile Val 
    770                 775                 780                 


Ile Val Pro Ser Leu Asn Pro Asp Gly Arg Glu Arg Ala Gln Glu Lys 
785                 790                 795                 800 


Asp Cys Thr Ser Lys Ile Gly Gln Thr Asn Ala Arg Gly Lys Asp Leu 
                805                 810                 815     


Asp Thr Asp Phe Thr Asn Asn Ala Ser Gln Pro Glu Thr Lys Ala Ile 
            820                 825                 830         


Ile Glu Asn Leu Ile Gln Lys Gln Asp Phe Ser Leu Ser Val Ala Leu 
        835                 840                 845             


Asp Gly Gly Ser Met Leu Val Thr Tyr Pro Tyr Asp Lys Pro Val Gln 
    850                 855                 860                 


Thr Val Glu Asn Lys Glu Thr Leu Lys His Leu Ala Ser Leu Tyr Ala 
865                 870                 875                 880 


Asn Asn His Pro Ser Met His Met Gly Gln Pro Ser Cys Pro Asn Lys 
                885                 890                 895     


Ser Asp Glu Asn Ile Pro Gly Gly Val Met Arg Gly Ala Glu Trp His 
            900                 905                 910         


Ser His Leu Gly Ser Met Lys Asp Tyr Ser Val Thr Tyr Gly His Cys 
        915                 920                 925             


Pro Glu Ile Thr Val Tyr Thr Ser Cys Cys Tyr Phe Pro Ser Ala Ala 
    930                 935                 940                 


Arg Leu Pro Ser Leu Trp Ala Asp Asn Lys Arg Ser Leu Leu Ser Met 
945                 950                 955                 960 


Leu Val Glu Val His Lys Gly Val His Gly Phe Val Lys Asp Lys Thr 
                965                 970                 975     


Gly Lys Pro Ile Ser Lys Ala Val Ile Val Leu Asn Glu Gly Ile Lys 
            980                 985                 990         


Val Gln Thr Lys Glu Gly Gly Tyr  Phe His Val Leu Leu  Ala Pro Gly 
        995                 1000                 1005             


Val His  Asn Ile Ile Ala Ile  Ala Asp Gly Tyr Gln  Gln Gln His 
    1010                 1015                 1020             


Ser Gln  Val Phe Val His His  Asp Ala Ala Ser Ser  Val Val Ile 
    1025                 1030                 1035             


Val Phe  Asp Thr Asp Asn Arg  Ile Phe Gly Leu Pro  Arg Glu Leu 
    1040                 1045                 1050             


Val Val  Thr Val Ser Gly Ala  Thr Met Ser Ala Leu  Ile Leu Thr 
    1055                 1060                 1065             


Ala Cys  Ile Ile Trp Cys Ile  Cys Ser Ile Lys Ser  Asn Arg His 
    1070                 1075                 1080             


Lys Asp  Gly Phe His Arg Leu  Arg Gln His His Asp  Glu Tyr Glu 
    1085                 1090                 1095             


Asp Glu  Ile Arg Met Met Ser  Thr Gly Ser Lys Lys  Ser Leu Leu 
    1100                 1105                 1110             


Ser His  Glu Phe Gln Asp Glu  Thr Asp Thr Glu Glu  Glu Thr Leu 
    1115                 1120                 1125             


Tyr Ser  Ser Lys His 
    1130             


<210>  2513
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPEB1__Homo_sapiens__NP_001073001

<400>  2513

Met Leu Phe Pro Thr Ser Ala Gln Glu Ser Ser Arg Gly Leu Pro Asp 
1               5                   10                  15      


Ala Asn Asp Leu Cys Leu Gly Leu Gln Ser Leu Ser Leu Thr Gly Trp 
            20                  25                  30          


Asp Arg Pro Trp Ser Thr Gln Asp Ser Asp Ser Ser Ala Gln Ser Ser 
        35                  40                  45              


Thr His Ser Val Leu Ser Met Leu His Asn Pro Leu Gly Asn Val Leu 
    50                  55                  60                  


Gly Lys Pro Pro Leu Ser Phe Leu Pro Leu Asp Pro Leu Gly Ser Asp 
65                  70                  75                  80  


Leu Val Asp Lys Phe Pro Ala Pro Ser Val Arg Gly Ser Arg Leu Asp 
                85                  90                  95      


Thr Arg Pro Ile Leu Asp Ser Arg Ser Ser Ser Pro Ser Asp Ser Asp 
            100                 105                 110         


Thr Ser Gly Phe Ser Ser Gly Ser Asp His Leu Ser Asp Leu Ile Ser 
        115                 120                 125             


Ser Leu Arg Ile Ser Pro Pro Leu Pro Phe Leu Ser Leu Ser Gly Gly 
    130                 135                 140                 


Gly Pro Arg Asp Pro Leu Lys Met Gly Val Gly Ser Arg Met Asp Gln 
145                 150                 155                 160 


Glu Gln Ala Ala Leu Ala Ala Val Thr Pro Ser Pro Thr Ser Ala Ser 
                165                 170                 175     


Lys Arg Trp Pro Gly Ala Ser Val Trp Pro Ser Trp Asp Leu Leu Glu 
            180                 185                 190         


Ala Pro Lys Asp Pro Phe Ser Ile Glu Arg Glu Ala Arg Leu His Arg 
        195                 200                 205             


Gln Ala Ala Ala Val Asn Glu Ala Thr Cys Thr Trp Ser Gly Gln Leu 
    210                 215                 220                 


Pro Pro Arg Asn Tyr Lys Asn Pro Ile Tyr Ser Cys Lys Val Phe Leu 
225                 230                 235                 240 


Gly Gly Val Pro Trp Asp Ile Thr Glu Ala Gly Leu Val Asn Thr Phe 
                245                 250                 255     


Arg Val Phe Gly Ser Leu Ser Val Glu Trp Pro Gly Lys Asp Gly Lys 
            260                 265                 270         


His Pro Arg Cys Pro Pro Lys Gly Asn Met Pro Lys Gly Tyr Val Tyr 
        275                 280                 285             


Leu Val Phe Glu Leu Glu Lys Ser Val Arg Ser Leu Leu Gln Ala Cys 
    290                 295                 300                 


Ser His Asp Pro Leu Ser Pro Asp Gly Leu Ser Glu Tyr Tyr Phe Lys 
305                 310                 315                 320 


Met Ser Ser Arg Arg Met Arg Cys Lys Glu Val Gln Val Ile Pro Trp 
                325                 330                 335     


Val Leu Ala Asp Ser Asn Phe Val Arg Ser Pro Ser Gln Arg Leu Asp 
            340                 345                 350         


Pro Ser Arg Thr Val Phe Val Gly Ala Leu His Gly Met Leu Asn Ala 
        355                 360                 365             


Glu Ala Leu Ala Ala Ile Leu Asn Asp Leu Phe Gly Gly Val Val Tyr 
    370                 375                 380                 


Ala Gly Ile Asp Thr Asp Lys His Lys Tyr Pro Ile Gly Ser Gly Arg 
385                 390                 395                 400 


Val Thr Phe Asn Asn Gln Arg Ser Tyr Leu Lys Ala Val Ser Ala Ala 
                405                 410                 415     


Phe Val Glu Ile Lys Thr Thr Lys Phe Thr Lys Lys Val Gln Ile Asp 
            420                 425                 430         


Pro Tyr Leu Glu Asp Ser Leu Cys His Ile Cys Ser Ser Gln Pro Gly 
        435                 440                 445             


Pro Phe Phe Cys Arg Asp Gln Val Cys Phe Lys Tyr Phe Cys Arg Ser 
    450                 455                 460                 


Cys Trp His Trp Arg His Ser Met Glu Gly Leu Arg His His Ser Pro 
465                 470                 475                 480 


Leu Met Arg Asn Gln Lys Asn Arg Asp Ser Ser 
                485                 490     


<210>  2514
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPEB3__Homo_sapiens__NP_001171608

<400>  2514

Met Gln Asp Asp Leu Leu Met Asp Lys Ser Lys Thr Gln Pro Gln Pro 
1               5                   10                  15      


Gln Gln Gln Gln Arg Gln Gln Gln Gln Pro Gln Pro Glu Ser Ser Val 
            20                  25                  30          


Ser Glu Ala Pro Ser Thr Pro Leu Ser Ser Glu Thr Pro Lys Pro Glu 
        35                  40                  45              


Glu Asn Ser Ala Val Pro Ala Leu Ser Pro Ala Ala Ala Pro Pro Ala 
    50                  55                  60                  


Pro Asn Gly Pro Asp Lys Met Gln Met Glu Ser Pro Leu Leu Pro Gly 
65                  70                  75                  80  


Leu Ser Phe His Gln Pro Pro Gln Gln Pro Pro Pro Pro Gln Glu Pro 
                85                  90                  95      


Ala Ala Pro Gly Ala Ser Leu Ser Pro Ser Phe Gly Ser Thr Trp Ser 
            100                 105                 110         


Thr Gly Thr Thr Asn Ala Val Glu Asp Ser Phe Phe Gln Gly Ile Thr 
        115                 120                 125             


Pro Val Asn Gly Thr Met Leu Phe Gln Asn Phe Pro His His Val Asn 
    130                 135                 140                 


Pro Val Phe Gly Gly Thr Phe Ser Pro Gln Ile Gly Leu Ala Gln Thr 
145                 150                 155                 160 


Gln His His Gln Gln Pro Pro Pro Pro Ala Pro Ala Pro Gln Pro Ala 
                165                 170                 175     


Gln Pro Ala Gln Pro Pro Gln Ala Gln Pro Pro Gln Gln Arg Arg Ser 
            180                 185                 190         


Pro Ala Ser Pro Ser Gln Ala Pro Tyr Ala Gln Arg Ser Ala Ala Ala 
        195                 200                 205             


Ala Tyr Gly His Gln Pro Ile Met Thr Ser Lys Pro Ser Ser Ser Ser 
    210                 215                 220                 


Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ala Ser Ser 
225                 230                 235                 240 


Ser Trp Asn Thr His Gln Ser Val Asn Ala Ala Trp Ser Ala Pro Ser 
                245                 250                 255     


Asn Pro Trp Gly Gly Leu Gln Ala Gly Arg Asp Pro Arg Arg Ala Val 
            260                 265                 270         


Gly Val Gly Val Gly Val Gly Val Gly Val Pro Ser Pro Leu Asn Pro 
        275                 280                 285             


Ile Ser Pro Leu Lys Lys Pro Phe Ser Ser Asn Val Ile Ala Pro Pro 
    290                 295                 300                 


Lys Phe Pro Arg Ala Ala Pro Leu Thr Ser Lys Ser Trp Met Glu Asp 
305                 310                 315                 320 


Asn Ala Phe Arg Thr Asp Asn Gly Asn Asn Leu Leu Pro Phe Gln Asp 
                325                 330                 335     


Arg Ser Arg Pro Tyr Asp Thr Phe Asn Leu His Ser Leu Glu Asn Ser 
            340                 345                 350         


Leu Met Asp Met Ile Arg Thr Asp His Glu Pro Leu Lys Gly Arg Met 
        355                 360                 365             


Gly Ile Asn Phe His His Pro Gly Thr Asp Asn Ile Met Ala Leu Asn 
    370                 375                 380                 


Ser Arg Ser Ser Leu Phe Pro Phe Glu Asp Ala Phe Leu Asp Asp Ser 
385                 390                 395                 400 


His Gly Asp Gln Ala Leu Ser Ser Gly Leu Ser Ser Pro Thr Arg Cys 
                405                 410                 415     


Gln Asn Gly Glu Arg Val Glu Arg Tyr Ser Arg Lys Val Phe Val Gly 
            420                 425                 430         


Gly Leu Pro Pro Asp Ile Asp Glu Asp Glu Ile Thr Ala Ser Phe Arg 
        435                 440                 445             


Arg Phe Gly Pro Leu Val Val Asp Trp Pro His Lys Ala Glu Ser Lys 
    450                 455                 460                 


Ser Tyr Phe Pro Pro Lys Gly Tyr Ala Phe Leu Leu Phe Gln Glu Glu 
465                 470                 475                 480 


Ser Ser Val Gln Ala Leu Ile Asp Ala Cys Leu Glu Glu Asp Gly Lys 
                485                 490                 495     


Leu Tyr Leu Cys Val Ser Ser Pro Thr Ile Lys Asp Lys Pro Val Gln 
            500                 505                 510         


Ile Arg Pro Trp Asn Leu Ser Asp Ser Asp Phe Val Met Asp Gly Ser 
        515                 520                 525             


Gln Pro Leu Asp Pro Arg Lys Thr Ile Phe Val Gly Gly Val Pro Arg 
    530                 535                 540                 


Pro Leu Arg Ala Val Glu Leu Ala Met Ile Met Asp Arg Leu Tyr Gly 
545                 550                 555                 560 


Gly Val Cys Tyr Ala Gly Ile Asp Thr Asp Pro Glu Leu Lys Tyr Pro 
                565                 570                 575     


Lys Gly Ala Gly Arg Val Ala Phe Ser Asn Gln Gln Ser Tyr Ile Ala 
            580                 585                 590         


Ala Ile Ser Ala Arg Phe Val Gln Leu Gln His Asn Asp Ile Asp Lys 
        595                 600                 605             


Arg Val Glu Val Lys Pro Tyr Val Leu Asp Asp Gln Met Cys Asp Glu 
    610                 615                 620                 


Cys Gln Gly Thr Arg Cys Gly Gly Lys Phe Ala Pro Phe Phe Cys Ala 
625                 630                 635                 640 


Asn Val Thr Cys Leu Gln Tyr Tyr Cys Glu Tyr Cys Trp Ala Ser Ile 
                645                 650                 655     


His Ser Arg Ala Gly Arg Glu Phe His Lys Pro Leu Val Lys Glu Gly 
            660                 665                 670         


Gly Asp Arg Pro Arg His Val Pro Phe Arg Trp Ser 
        675                 680                 


<210>  2515
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPEB4__Homo_sapiens__NP_085130

<400>  2515

Met Gly Asp Tyr Gly Phe Gly Val Leu Val Gln Ser Asn Thr Gly Asn 
1               5                   10                  15      


Lys Ser Ala Phe Pro Val Arg Phe His Pro His Leu Gln Pro Pro His 
            20                  25                  30          


His His Gln Asn Ala Thr Pro Ser Pro Ala Ala Phe Ile Asn Asn Asn 
        35                  40                  45              


Thr Ala Ala Asn Gly Ser Ser Ala Gly Ser Ala Trp Leu Phe Pro Ala 
    50                  55                  60                  


Pro Ala Thr His Asn Ile Gln Asp Glu Ile Leu Gly Ser Glu Lys Ala 
65                  70                  75                  80  


Lys Ser Gln Gln Gln Glu Gln Gln Asp Pro Leu Glu Lys Gln Gln Leu 
                85                  90                  95      


Ser Pro Ser Pro Gly Gln Glu Ala Gly Ile Leu Pro Glu Thr Glu Lys 
            100                 105                 110         


Ala Lys Ser Glu Glu Asn Gln Gly Asp Asn Ser Ser Glu Asn Gly Asn 
        115                 120                 125             


Gly Lys Glu Lys Ile Arg Ile Glu Ser Pro Val Leu Thr Gly Phe Asp 
    130                 135                 140                 


Tyr Gln Glu Ala Thr Gly Leu Gly Thr Ser Thr Gln Pro Leu Thr Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Leu Thr Gly Phe Ser Asn Trp Ser Ala Ala Ile Ala 
                165                 170                 175     


Pro Ser Ser Ser Thr Ile Ile Asn Glu Asp Ala Ser Phe Phe His Gln 
            180                 185                 190         


Gly Gly Val Pro Ala Ala Ser Ala Asn Asn Gly Ala Leu Leu Phe Gln 
        195                 200                 205             


Asn Phe Pro His His Val Ser Pro Gly Phe Gly Gly Ser Phe Ser Pro 
    210                 215                 220                 


Gln Ile Gly Pro Leu Ser Gln His His Pro His His Pro His Phe Gln 
225                 230                 235                 240 


His His His Ser Gln His Gln Gln Gln Arg Arg Ser Pro Ala Ser Pro 
                245                 250                 255     


His Pro Pro Pro Phe Thr His Arg Asn Ala Ala Phe Asn Gln Leu Pro 
            260                 265                 270         


His Leu Ala Asn Asn Leu Asn Lys Pro Pro Ser Pro Trp Ser Ser Tyr 
        275                 280                 285             


Gln Ser Pro Ser Pro Thr Pro Ser Ser Ser Trp Ser Pro Gly Gly Gly 
    290                 295                 300                 


Gly Tyr Gly Gly Trp Gly Gly Ser Gln Gly Arg Asp His Arg Arg Gly 
305                 310                 315                 320 


Leu Asn Gly Gly Ile Thr Pro Leu Asn Ser Ile Ser Pro Leu Lys Lys 
                325                 330                 335     


Asn Phe Ala Ser Asn His Ile Gln Leu Gln Lys Tyr Ala Arg Pro Ser 
            340                 345                 350         


Ser Ala Phe Ala Pro Lys Ser Trp Met Glu Asp Ser Leu Asn Arg Ala 
        355                 360                 365             


Asp Asn Ile Phe Pro Phe Pro Asp Arg Pro Arg Thr Phe Asp Met His 
    370                 375                 380                 


Ser Leu Glu Ser Ser Leu Ile Asp Ile Met Arg Ala Glu Asn Asp Thr 
385                 390                 395                 400 


Ile Lys Gly Arg Leu Asn Tyr Ser Tyr Pro Gly Ser Asp Ser Ser Leu 
                405                 410                 415     


Leu Ile Asn Ala Arg Thr Tyr Gly Arg Arg Arg Gly Gln Ser Ser Leu 
            420                 425                 430         


Phe Pro Met Glu Asp Gly Phe Leu Asp Asp Gly Arg Gly Asp Gln Pro 
        435                 440                 445             


Leu His Ser Gly Leu Gly Ser Pro His Cys Phe Ser His Gln Asn Gly 
    450                 455                 460                 


Glu Arg Val Glu Arg Tyr Ser Arg Lys Val Phe Val Gly Gly Leu Pro 
465                 470                 475                 480 


Pro Asp Ile Asp Glu Asp Glu Ile Thr Ala Ser Phe Arg Arg Phe Gly 
                485                 490                 495     


Pro Leu Ile Val Asp Trp Pro His Lys Ala Glu Ser Lys Ser Tyr Phe 
            500                 505                 510         


Pro Pro Lys Gly Tyr Ala Phe Leu Leu Phe Gln Asp Glu Ser Ser Val 
        515                 520                 525             


Gln Ala Leu Ile Asp Ala Cys Ile Glu Glu Asp Gly Lys Leu Tyr Leu 
    530                 535                 540                 


Cys Val Ser Ser Pro Thr Ile Lys Asp Lys Pro Val Gln Ile Arg Pro 
545                 550                 555                 560 


Trp Asn Leu Ser Asp Ser Asp Phe Val Met Asp Gly Ser Gln Pro Leu 
                565                 570                 575     


Asp Pro Arg Lys Thr Ile Phe Val Gly Gly Val Pro Arg Pro Leu Arg 
            580                 585                 590         


Ala Val Glu Leu Ala Met Ile Met Asp Arg Leu Tyr Gly Gly Val Cys 
        595                 600                 605             


Tyr Ala Gly Ile Asp Thr Asp Pro Glu Leu Lys Tyr Pro Lys Gly Ala 
    610                 615                 620                 


Gly Arg Val Ala Phe Ser Asn Gln Gln Ser Tyr Ile Ala Ala Ile Ser 
625                 630                 635                 640 


Ala Arg Phe Val Gln Leu Gln His Gly Glu Ile Asp Lys Arg Val Glu 
                645                 650                 655     


Val Lys Pro Tyr Val Leu Asp Asp Gln Leu Cys Asp Glu Cys Gln Gly 
            660                 665                 670         


Ala Arg Cys Gly Gly Lys Phe Ala Pro Phe Phe Cys Ala Asn Val Thr 
        675                 680                 685             


Cys Leu Gln Tyr Tyr Cys Glu Tyr Cys Trp Ala Ala Ile His Ser Arg 
    690                 695                 700                 


Ala Gly Arg Glu Phe His Lys Pro Leu Val Lys Glu Gly Gly Asp Arg 
705                 710                 715                 720 


Pro Arg His Ile Ser Phe Arg Trp Asn 
                725                 


<210>  2516
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPED1__Homo_sapiens__NP_001099003

<400>  2516

Met Val Cys Arg Pro Val Phe Pro Cys Arg Arg Arg Phe Cys Pro Arg 
1               5                   10                  15      


Pro Phe Leu Val Gly Leu Val Val Ala Ile Cys Leu Phe Tyr Gln Thr 
            20                  25                  30          


Leu Thr Leu Arg Gly Ser Arg Lys Leu Thr Ala Ala Ala Pro Gly Ala 
        35                  40                  45              


Val Pro His Thr Ser Thr Glu Thr Gln Ala Ser Arg Cys Lys Lys Gly 
    50                  55                  60                  


Phe Ser Gln Asp Lys Gln Cys Phe Leu Leu Ser Gly Asn Ala Gln Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Glu Ser Met Glu Thr His Phe Gly Ser His Gly 
                85                  90                  95      


Arg Arg Ala Ile Leu Tyr Arg Pro Pro Phe Tyr Ser Lys Thr Glu Leu 
            100                 105                 110         


Gln Leu His Gln His Ile Leu Thr Gln His Gly Tyr Thr Val Val Ile 
        115                 120                 125             


Ala Glu Glu Arg Leu Asn Ala Gly Leu Gly Pro Gly Leu Leu Glu Gln 
    130                 135                 140                 


Gly Asp Leu Gly Ser Trp Asp Leu Leu Ile Cys Leu Ser Ser Lys Lys 
145                 150                 155                 160 


Ala Glu Gly Thr Pro Cys Ile Ser Lys Glu Val Met Cys Gln Leu Gly 
                165                 170                 175     


Leu His Gln Lys Ala Asn Arg Leu Pro Glu Ile Gln Gln Pro Leu Cys 
            180                 185                 190         


Arg Lys Glu Gly Leu Cys Gln Ile Val Arg Arg Phe Pro Glu Leu Gln 
        195                 200                 205             


Leu Pro Val Ser Pro Ser Val Cys Leu Asp Gln Gly Met Gln Leu Lys 
    210                 215                 220                 


Pro Ser Thr Ser Ser His Leu Leu Lys Thr Val Lys Pro Arg Val Trp 
225                 230                 235                 240 


Lys Pro Gly Asp Trp Ser Arg Glu Gln Leu Asn Glu Thr Thr Val Leu 
                245                 250                 255     


Ala Pro His Glu Thr Ile Phe Arg Ala Glu Asp Leu Ser Val Ile Leu 
            260                 265                 270         


Lys Ala Tyr Val Leu Val Thr Ser Leu Thr Pro Leu Arg Ala Phe Ile 
        275                 280                 285             


His Ser Thr Gly Thr Val Trp Asn Pro Pro Lys Lys Lys Arg Phe Thr 
    290                 295                 300                 


Val Lys Leu Gln Thr Phe Phe Glu Thr Phe Leu Arg Ala Ser Ser Pro 
305                 310                 315                 320 


Gln Gln Ala Phe Asp Ile Met Lys Glu Ala Ile Gly Lys Leu Leu Leu 
                325                 330                 335     


Ala Ala Glu Val Phe Ser Glu Thr Ser Thr Leu Gly Pro Lys Thr Phe 
            340                 345                 350         


His Arg Cys Arg Phe Cys Phe Gln Leu Leu Thr Phe Asp Ile Gly Tyr 
        355                 360                 365             


Gly Ser Phe Met Tyr Pro Val Val Leu Gln Val His Glu His Leu Asn 
    370                 375                 380                 


Phe Gln Asp Tyr Asp Asn Met Asp Phe Glu Asp Gln Asn Thr Glu Glu 
385                 390                 395                 400 


Phe Leu Leu Asn Asp Thr Phe Asn Phe Leu Phe Pro Asn Glu Ser Ser 
                405                 410                 415     


Leu Ser Ile Phe Ser Glu Ile Phe Gln Arg Leu Tyr Arg Ser Asp Val 
            420                 425                 430         


Phe Lys Gly Glu Asn Tyr Gln Lys Glu Leu Asn Gln Cys Leu Ser Leu 
        435                 440                 445             


Glu Glu Ile Asn Ser Ile Met Thr Phe Ile Lys Glu Leu Gly Ser Leu 
    450                 455                 460                 


Gly Gln Phe Gln Leu Leu Phe Pro Ser Thr Thr Pro Gly Ile Gln Ser 
465                 470                 475                 480 


Leu Met His Glu Phe Tyr Asp Val Ala Asn Pro Val Gly Asn Pro Gly 
                485                 490                 495     


Ser Val Leu Thr Gln Tyr Trp Ser Leu Leu Asn Val Phe Glu Gln Phe 
            500                 505                 510         


Gln Phe Met Asn Lys Lys Thr Gln Pro His Pro Leu Glu Trp Asn Ser 
        515                 520                 525             


Phe Thr Glu Asp Lys Asn Ile Glu Lys Pro Gln Val Pro Phe Asp Ala 
    530                 535                 540                 


Ile Glu Asn Lys Lys Ala Ala Val Pro Gln Ile Lys Asn Glu Asn Lys 
545                 550                 555                 560 


Glu Ile His Cys Ser Asp Asp Glu Asn Thr Pro Cys His Ile Lys Gln 
                565                 570                 575     


Ile Phe Thr His Pro His Leu Glu Leu Asn Pro Asp Phe His Pro Lys 
            580                 585                 590         


Ile Lys Asp Tyr Tyr Cys Glu Val Pro Phe Asp Val Val Thr Val Thr 
        595                 600                 605             


Ile Gly Val Glu Thr Pro Lys Cys Leu Cys Lys Val His Leu Tyr Glu 
    610                 615                 620                 


Gln Ala Gly Pro Ser Phe Ala Ser Tyr Pro Leu Gly Leu Gly Met Asn 
625                 630                 635                 640 


Lys Ile Ser Ile Phe Val Val Asp Glu Ser Pro Ala His Gly Glu Thr 
                645                 650                 655     


Leu Ile Thr Tyr Lys Leu Thr Ile Tyr Arg Glu Asp Arg Pro Ser Leu 
            660                 665                 670         


Pro Leu Phe Glu Ala Phe Thr Ala Cys Gly Phe Val Gln Asp Cys Gly 
        675                 680                 685             


Leu Leu Ile His Pro Glu Glu Thr Cys Gly Leu Gln Pro Ile Ser Ser 
    690                 695                 700                 


Asp Tyr Ile Glu Ala Ile Leu Gln Ser Glu Leu Lys Arg Cys Pro Ser 
705                 710                 715                 720 


Gly Asp Met Lys Gly Gln Trp Ile Val Pro Cys Leu Ser Cys Ser Asp 
                725                 730                 735     


Asn Arg Thr Cys Asp Trp Arg Glu Ile Thr Trp Gln Pro His Asn Cys 
            740                 745                 750         


Gln Tyr Gly Val Leu Thr Lys Pro Gln Leu Gln Gln Cys Leu Gly Gly 
        755                 760                 765             


Arg Lys Leu Gly Val Asp Val Gln Arg Val Pro Arg Ser Arg Asn 
    770                 775                 780             


<210>  2517
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPE__Homo_sapiens__NP_001864

<400>  2517

Met Ala Gly Arg Gly Gly Ser Ala Leu Leu Ala Leu Cys Gly Ala Leu 
1               5                   10                  15      


Ala Ala Cys Gly Trp Leu Leu Gly Ala Glu Ala Gln Glu Pro Gly Ala 
            20                  25                  30          


Pro Ala Ala Gly Met Arg Arg Arg Arg Arg Leu Gln Gln Glu Asp Gly 
        35                  40                  45              


Ile Ser Phe Glu Tyr His Arg Tyr Pro Glu Leu Arg Glu Ala Leu Val 
    50                  55                  60                  


Ser Val Trp Leu Gln Cys Thr Ala Ile Ser Arg Ile Tyr Thr Val Gly 
65                  70                  75                  80  


Arg Ser Phe Glu Gly Arg Glu Leu Leu Val Ile Glu Leu Ser Asp Asn 
                85                  90                  95      


Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn 
            100                 105                 110         


Met His Gly Asn Glu Ala Val Gly Arg Glu Leu Leu Ile Phe Leu Ala 
        115                 120                 125             


Gln Tyr Leu Cys Asn Glu Tyr Gln Lys Gly Asn Glu Thr Ile Val Asn 
    130                 135                 140                 


Leu Ile His Ser Thr Arg Ile His Ile Met Pro Ser Leu Asn Pro Asp 
145                 150                 155                 160 


Gly Phe Glu Lys Ala Ala Ser Gln Pro Gly Glu Leu Lys Asp Trp Phe 
                165                 170                 175     


Val Gly Arg Ser Asn Ala Gln Gly Ile Asp Leu Asn Arg Asn Phe Pro 
            180                 185                 190         


Asp Leu Asp Arg Ile Val Tyr Val Asn Glu Lys Glu Gly Gly Pro Asn 
        195                 200                 205             


Asn His Leu Leu Lys Asn Met Lys Lys Ile Val Asp Gln Asn Thr Lys 
    210                 215                 220                 


Leu Ala Pro Glu Thr Lys Ala Val Ile His Trp Ile Met Asp Ile Pro 
225                 230                 235                 240 


Phe Val Leu Ser Ala Asn Leu His Gly Gly Asp Leu Val Ala Asn Tyr 
                245                 250                 255     


Pro Tyr Asp Glu Thr Arg Ser Gly Ser Ala His Glu Tyr Ser Ser Ser 
            260                 265                 270         


Pro Asp Asp Ala Ile Phe Gln Ser Leu Ala Arg Ala Tyr Ser Ser Phe 
        275                 280                 285             


Asn Pro Ala Met Ser Asp Pro Asn Arg Pro Pro Cys Arg Lys Asn Asp 
    290                 295                 300                 


Asp Asp Ser Ser Phe Val Asp Gly Thr Thr Asn Gly Gly Ala Trp Tyr 
305                 310                 315                 320 


Ser Val Pro Gly Gly Met Gln Asp Phe Asn Tyr Leu Ser Ser Asn Cys 
                325                 330                 335     


Phe Glu Ile Thr Val Glu Leu Ser Cys Glu Lys Phe Pro Pro Glu Glu 
            340                 345                 350         


Thr Leu Lys Thr Tyr Trp Glu Asp Asn Lys Asn Ser Leu Ile Ser Tyr 
        355                 360                 365             


Leu Glu Gln Ile His Arg Gly Val Lys Gly Phe Val Arg Asp Leu Gln 
    370                 375                 380                 


Gly Asn Pro Ile Ala Asn Ala Thr Ile Ser Val Glu Gly Ile Asp His 
385                 390                 395                 400 


Asp Val Thr Ser Ala Lys Asp Gly Asp Tyr Trp Arg Leu Leu Ile Pro 
                405                 410                 415     


Gly Asn Tyr Lys Leu Thr Ala Ser Ala Pro Gly Tyr Leu Ala Ile Thr 
            420                 425                 430         


Lys Lys Val Ala Val Pro Tyr Ser Pro Ala Ala Gly Val Asp Phe Glu 
        435                 440                 445             


Leu Glu Ser Phe Ser Glu Arg Lys Glu Glu Glu Lys Glu Glu Leu Met 
    450                 455                 460                 


Glu Trp Trp Lys Met Met Ser Glu Thr Leu Asn Phe 
465                 470                 475     


<210>  2518
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP__Homo_sapiens__NP_000087

<400>  2518

Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro 
1               5                   10                  15      


Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr 
            20                  25                  30          


Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp 
        35                  40                  45              


Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly 
    50                  55                  60                  


Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe 
65                  70                  75                  80  


Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile 
                85                  90                  95      


Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu 
            100                 105                 110         


Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys 
        115                 120                 125             


Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg 
    130                 135                 140                 


Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu 
145                 150                 155                 160 


Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr 
                165                 170                 175     


Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly 
            180                 185                 190         


Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu 
        195                 200                 205             


Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val 
    210                 215                 220                 


Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys 
225                 230                 235                 240 


Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser 
                245                 250                 255     


Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly 
            260                 265                 270         


Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met 
        275                 280                 285             


Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu 
    290                 295                 300                 


Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr 
305                 310                 315                 320 


Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu 
                325                 330                 335     


Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe 
            340                 345                 350         


Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly 
        355                 360                 365             


Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn 
    370                 375                 380                 


Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala 
385                 390                 395                 400 


Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile 
                405                 410                 415     


Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser 
            420                 425                 430         


Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile 
        435                 440                 445             


Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr 
    450                 455                 460                 


Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val 
465                 470                 475                 480 


Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn 
                485                 490                 495     


Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr 
            500                 505                 510         


Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr 
        515                 520                 525             


Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp 
    530                 535                 540                 


Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys 
545                 550                 555                 560 


Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys 
                565                 570                 575     


Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu 
            580                 585                 590         


Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp 
        595                 600                 605             


Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn 
    610                 615                 620                 


Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp 
625                 630                 635                 640 


Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His 
                645                 650                 655     


Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg 
            660                 665                 670         


Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp 
        675                 680                 685             


Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His 
    690                 695                 700                 


Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg 
705                 710                 715                 720 


Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile 
                725                 730                 735     


Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu 
            740                 745                 750         


Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu 
        755                 760                 765             


Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr 
    770                 775                 780                 


Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala 
785                 790                 795                 800 


Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val 
                805                 810                 815     


Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr 
            820                 825                 830         


Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro 
        835                 840                 845             


Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg 
    850                 855                 860                 


Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr 
865                 870                 875                 880 


Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro 
                885                 890                 895     


Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg 
            900                 905                 910         


Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser 
        915                 920                 925             


Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys 
    930                 935                 940                 


Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala 
945                 950                 955                 960 


Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val 
                965                 970                 975     


Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp 
            980                 985                 990         


Leu His Thr Val His Phe His Gly  His Ser Phe Gln Tyr  Lys His Arg 
        995                 1000                 1005             


Gly Val  Tyr Ser Ser Asp Val  Phe Asp Ile Phe Pro  Gly Thr Tyr 
    1010                 1015                 1020             


Gln Thr  Leu Glu Met Phe Pro  Arg Thr Pro Gly Ile  Trp Leu Leu 
    1025                 1030                 1035             


His Cys  His Val Thr Asp His  Ile His Ala Gly Met  Glu Thr Thr 
    1040                 1045                 1050             


Tyr Thr  Val Leu Gln Asn Glu  Asp Thr Lys Ser Gly  
    1055                 1060                 1065 


<210>  2519
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPLX1__Homo_sapiens__NP_006642

<400>  2519

Met Glu Phe Val Met Lys Gln Ala Leu Gly Gly Ala Thr Lys Asp Met 
1               5                   10                  15      


Gly Lys Met Leu Gly Gly Asp Glu Glu Lys Asp Pro Asp Ala Ala Lys 
            20                  25                  30          


Lys Glu Glu Glu Arg Gln Glu Ala Leu Arg Gln Ala Glu Glu Glu Arg 
        35                  40                  45              


Lys Ala Lys Tyr Ala Lys Met Glu Ala Glu Arg Glu Ala Val Arg Gln 
    50                  55                  60                  


Gly Ile Arg Asp Lys Tyr Gly Ile Lys Lys Lys Glu Glu Arg Glu Ala 
65                  70                  75                  80  


Glu Ala Gln Ala Ala Met Glu Ala Asn Ser Glu Gly Ser Leu Thr Arg 
                85                  90                  95      


Pro Lys Lys Ala Ile Pro Pro Gly Cys Gly Asp Glu Val Glu Glu Glu 
            100                 105                 110         


Asp Glu Ser Ile Leu Asp Thr Val Ile Lys Tyr Leu Pro Gly Pro Leu 
        115                 120                 125             


Gln Asp Met Leu Lys Lys 
    130                 


<210>  2520
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPLX2__Homo_sapiens__XP_011532721

<400>  2520

Met Asp Phe Val Met Lys Gln Ala Leu Gly Gly Ala Thr Lys Asp Met 
1               5                   10                  15      


Gly Lys Met Leu Gly Gly Glu Glu Glu Lys Asp Pro Asp Ala Gln Lys 
            20                  25                  30          


Lys Glu Glu Glu Arg Gln Glu Ala Leu Arg Gln Gln Glu Glu Glu Arg 
        35                  40                  45              


Lys Ala Lys His Ala Arg Met Glu Ala Glu Arg Glu Lys Val Arg Gln 
    50                  55                  60                  


Gln Ile Arg Asp Lys Tyr Gly Leu Lys Lys Lys Glu Glu Lys Glu Ala 
65                  70                  75                  80  


Glu Glu Lys Ala Ala Leu Glu Gln Pro Cys Glu Gly Ser Leu Thr Arg 
                85                  90                  95      


Pro Lys Lys Ala Ile Pro Ala Gly Cys Gly Asp Glu Glu Glu Glu Glu 
            100                 105                 110         


Glu Glu Ser Ile Leu Asp Thr Val Leu Lys Tyr Leu Pro Gly Pro Leu 
        115                 120                 125             


Gln Asp Met Phe Lys Lys 
    130                 


<210>  2521
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPLX3__Homo_sapiens__NP_001025176

<400>  2521

Met Ala Phe Met Val Lys Thr Met Val Gly Gly Gln Leu Lys Asn Leu 
1               5                   10                  15      


Thr Gly Ser Leu Gly Gly Gly Glu Asp Lys Gly Asp Gly Asp Lys Ser 
            20                  25                  30          


Ala Ala Glu Ala Gln Gly Met Ser Arg Glu Glu Tyr Glu Glu Tyr Gln 
        35                  40                  45              


Lys Gln Leu Val Glu Glu Lys Met Glu Arg Asp Ala Gln Phe Thr Gln 
    50                  55                  60                  


Arg Lys Ala Glu Arg Ala Thr Leu Arg Ser His Phe Arg Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu Pro Lys Asn Glu Thr Asp Glu Ser Gln Ile Gln Met Ala Gly 
                85                  90                  95      


Gly Asp Val Glu Leu Pro Arg Glu Leu Ala Lys Met Ile Glu Glu Asp 
            100                 105                 110         


Thr Glu Glu Glu Glu Glu Lys Ala Ser Val Leu Gly Gln Leu Ala Ser 
        115                 120                 125             


Leu Pro Gly Leu Asn Leu Gly Ser Leu Lys Asp Lys Ala Gln Ala Thr 
    130                 135                 140                 


Leu Gly Asp Leu Lys Gln Ser Ala Glu Lys Cys His Val Met 
145                 150                 155             


<210>  2522
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPLX4__Homo_sapiens__NP_857637

<400>  2522

Met Ala Phe Leu Met Lys Ser Met Ile Ser Asn Gln Val Lys Asn Leu 
1               5                   10                  15      


Gly Phe Gly Gly Gly Ser Glu Glu Asn Lys Glu Glu Gly Gly Ala Ser 
            20                  25                  30          


Asp Pro Ala Ala Ala Gln Gly Met Thr Arg Glu Glu Tyr Glu Glu Tyr 
        35                  40                  45              


Gln Lys Gln Met Ile Glu Glu Lys Met Glu Arg Asp Ala Ala Phe Thr 
    50                  55                  60                  


Gln Lys Lys Ala Glu Arg Ala Cys Leu Arg Val His Leu Arg Glu Lys 
65                  70                  75                  80  


Tyr Arg Leu Pro Lys Ser Glu Met Asp Glu Asn Gln Ile Gln Met Ala 
                85                  90                  95      


Gly Asp Asp Val Asp Leu Pro Glu Asp Leu Arg Lys Met Val Asp Glu 
            100                 105                 110         


Asp Gln Glu Glu Glu Glu Asp Lys Asp Ser Ile Leu Gly Gln Ile Gln 
        115                 120                 125             


Asn Leu Gln Asn Met Asp Leu Asp Thr Ile Lys Glu Lys Ala Gln Ala 
    130                 135                 140                 


Thr Phe Thr Glu Ile Lys Gln Thr Ala Glu Gln Lys Cys Ser Val Met 
145                 150                 155                 160 


<210>  2523
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPM__Homo_sapiens__NP_001005502

<400>  2523

Met Asp Phe Pro Cys Leu Trp Leu Gly Leu Leu Leu Pro Leu Val Ala 
1               5                   10                  15      


Ala Leu Asp Phe Asn Tyr His Arg Gln Glu Gly Met Glu Ala Phe Leu 
            20                  25                  30          


Lys Thr Val Ala Gln Asn Tyr Ser Ser Val Thr His Leu His Ser Ile 
        35                  40                  45              


Gly Lys Ser Val Lys Gly Arg Asn Leu Trp Val Leu Val Val Gly Arg 
    50                  55                  60                  


Phe Pro Lys Glu His Arg Ile Gly Ile Pro Glu Phe Lys Tyr Val Ala 
65                  70                  75                  80  


Asn Met His Gly Asp Glu Thr Val Gly Arg Glu Leu Leu Leu His Leu 
                85                  90                  95      


Ile Asp Tyr Leu Val Thr Ser Asp Gly Lys Asp Pro Glu Ile Thr Asn 
            100                 105                 110         


Leu Ile Asn Ser Thr Arg Ile His Ile Met Pro Ser Met Asn Pro Asp 
        115                 120                 125             


Gly Phe Glu Ala Val Lys Lys Pro Asp Cys Tyr Tyr Ser Ile Gly Arg 
    130                 135                 140                 


Glu Asn Tyr Asn Gln Tyr Asp Leu Asn Arg Asn Phe Pro Asp Ala Phe 
145                 150                 155                 160 


Glu Tyr Asn Asn Val Ser Arg Gln Pro Glu Thr Val Ala Val Met Lys 
                165                 170                 175     


Trp Leu Lys Thr Glu Thr Phe Val Leu Ser Ala Asn Leu His Gly Gly 
            180                 185                 190         


Ala Leu Val Ala Ser Tyr Pro Phe Asp Asn Gly Val Gln Ala Thr Gly 
        195                 200                 205             


Ala Leu Tyr Ser Arg Ser Leu Thr Pro Asp Asp Asp Val Phe Gln Tyr 
    210                 215                 220                 


Leu Ala His Thr Tyr Ala Ser Arg Asn Pro Asn Met Lys Lys Gly Asp 
225                 230                 235                 240 


Glu Cys Lys Asn Lys Met Asn Phe Pro Asn Gly Val Thr Asn Gly Tyr 
                245                 250                 255     


Ser Trp Tyr Pro Leu Gln Gly Gly Met Gln Asp Tyr Asn Tyr Ile Trp 
            260                 265                 270         


Ala Gln Cys Phe Glu Ile Thr Leu Glu Leu Ser Cys Cys Lys Tyr Pro 
        275                 280                 285             


Arg Glu Glu Lys Leu Pro Ser Phe Trp Asn Asn Asn Lys Ala Ser Leu 
    290                 295                 300                 


Ile Glu Tyr Ile Lys Gln Val His Leu Gly Val Lys Gly Gln Val Phe 
305                 310                 315                 320 


Asp Gln Asn Gly Asn Pro Leu Pro Asn Val Ile Val Glu Val Gln Asp 
                325                 330                 335     


Arg Lys His Ile Cys Pro Tyr Arg Thr Asn Lys Tyr Gly Glu Tyr Tyr 
            340                 345                 350         


Leu Leu Leu Leu Pro Gly Ser Tyr Ile Ile Asn Val Thr Val Pro Gly 
        355                 360                 365             


His Asp Pro His Ile Thr Lys Val Ile Ile Pro Glu Lys Ser Gln Asn 
    370                 375                 380                 


Phe Ser Ala Leu Lys Lys Asp Ile Leu Leu Pro Phe Gln Gly Gln Leu 
385                 390                 395                 400 


Asp Ser Ile Pro Val Ser Asn Pro Ser Cys Pro Met Ile Pro Leu Tyr 
                405                 410                 415     


Arg Asn Leu Pro Asp His Ser Ala Ala Thr Lys Pro Ser Leu Phe Leu 
            420                 425                 430         


Phe Leu Val Ser Leu Leu His Ile Phe Phe Lys 
        435                 440             


<210>  2524
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPN1__Homo_sapiens__XP_011537601

<400>  2524

Met Ser Asp Leu Leu Ser Val Phe Leu His Leu Leu Leu Leu Phe Lys 
1               5                   10                  15      


Leu Val Ala Pro Val Thr Phe Arg His His Arg Tyr Asp Asp Leu Val 
            20                  25                  30          


Arg Thr Leu Tyr Lys Val Gln Asn Glu Cys Pro Gly Ile Thr Arg Val 
        35                  40                  45              


Tyr Ser Ile Gly Arg Ser Val Glu Gly Arg His Leu Tyr Val Leu Glu 
    50                  55                  60                  


Phe Ser Asp His Pro Gly Ile His Glu Pro Leu Glu Pro Glu Val Lys 
65                  70                  75                  80  


Tyr Val Gly Asn Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Met 
                85                  90                  95      


Leu Gln Leu Ser Glu Phe Leu Cys Glu Glu Phe Arg Asn Arg Asn Gln 
            100                 105                 110         


Arg Ile Val Gln Leu Ile Gln Asp Thr Arg Ile His Ile Leu Pro Ser 
        115                 120                 125             


Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Gln Gly Pro Asn Lys 
    130                 135                 140                 


Pro Gly Tyr Leu Val Gly Arg Asn Asn Ala Asn Gly Val Asp Leu Asn 
145                 150                 155                 160 


Arg Asn Phe Pro Asp Leu Asn Thr Tyr Ile Tyr Tyr Asn Glu Lys Tyr 
                165                 170                 175     


Gly Gly Pro Asn His His Leu Pro Leu Pro Asp Asn Trp Lys Ser Gln 
            180                 185                 190         


Pro Gln Leu Ala Leu His Arg Gln Pro Leu Ala Ser Ser Gln Val Glu 
        195                 200                 205             


Pro Glu Thr Arg Ala Val Ile Arg Trp Met His Ser Phe Asn Phe Val 
    210                 215                 220                 


Leu Ser Ala Asn Leu His Gly Gly Ala Val Val Ala Asn Tyr Pro Tyr 
225                 230                 235                 240 


Asp Lys Ser Phe Glu His Arg Val Arg Gly Val Arg Arg Thr Ala Ser 
                245                 250                 255     


Thr Pro Thr Pro Asp Asp Lys Leu Phe Gln Lys Leu Ala Lys Val Tyr 
            260                 265                 270         


Ser Tyr Ala His Gly Trp Met Phe Gln Gly Trp Asn Cys Gly Asp Tyr 
        275                 280                 285             


Phe Pro Asp Gly Ile Thr Asn Gly Ala Ser Trp Tyr Ser Leu Ser Lys 
    290                 295                 300                 


Gly Met Gln Asp Phe Asn Tyr Leu His Thr Asn Cys Phe Glu Ile Thr 
305                 310                 315                 320 


Leu Glu Leu Ser Cys Asp Lys Phe Pro Pro Glu Glu Glu Leu Gln Arg 
                325                 330                 335     


Glu Trp Leu Gly Asn Arg Glu Ala Leu Ile Gln Phe Leu Glu Gln Val 
            340                 345                 350         


His Gln Gly Ile Lys Gly Met Val Leu Asp Glu Asn Tyr Asn Asn Leu 
        355                 360                 365             


Ala Asn Ala Val Ile Ser Val Ser Gly Ile Asn His Asp Val Thr Ser 
    370                 375                 380                 


Gly Asp His Gly Asp Tyr Phe Arg Leu Leu Leu Pro Gly Ile Tyr Thr 
385                 390                 395                 400 


Val Ser Ala Thr Ala Pro Gly Tyr Asp Pro Glu Thr Val Thr Val Thr 
                405                 410                 415     


Val Gly Pro Ala Glu Pro Thr Leu Val Asn Phe His Leu Lys Arg Ser 
            420                 425                 430         


Ile Pro Gln Val Ser Pro Val Arg Arg Ala Pro Ser Arg Arg His Gly 
        435                 440                 445             


Val Arg Ala Lys Val Gln Pro Gln Ala Arg Lys Lys Glu Met Glu Met 
    450                 455                 460                 


Arg Gln Leu Gln Arg Gly Pro Ala 
465                 470         


<210>  2525
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPN2__Homo_sapiens__NP_001278917

<400>  2525

Met Leu Pro Gly Ala Trp Leu Leu Trp Thr Ser Leu Leu Leu Leu Ala 
1               5                   10                  15      


Arg Pro Ala Gln Pro Cys Pro Met Gly Cys Asp Cys Phe Val Gln Glu 
            20                  25                  30          


Val Phe Cys Ser Asp Glu Glu Leu Ala Thr Val Pro Leu Asp Ile Pro 
        35                  40                  45              


Pro Tyr Thr Lys Asn Ile Ile Phe Val Glu Thr Ser Phe Thr Thr Leu 
    50                  55                  60                  


Glu Thr Arg Ala Phe Gly Ser Asn Pro Asn Leu Thr Lys Val Val Phe 
65                  70                  75                  80  


Leu Asn Thr Gln Leu Cys Gln Phe Arg Pro Asp Ala Phe Gly Gly Leu 
                85                  90                  95      


Pro Arg Leu Glu Asp Leu Glu Val Thr Gly Ser Ser Phe Leu Asn Leu 
            100                 105                 110         


Ser Thr Asn Ile Phe Ser Asn Leu Thr Ser Leu Gly Lys Leu Thr Leu 
        115                 120                 125             


Asn Phe Asn Met Leu Glu Ala Leu Pro Glu Gly Leu Phe Gln His Leu 
    130                 135                 140                 


Ala Ala Leu Glu Ser Leu His Leu Gln Gly Asn Gln Leu Gln Ala Leu 
145                 150                 155                 160 


Pro Arg Arg Leu Phe Gln Pro Leu Thr His Leu Lys Thr Leu Asn Leu 
                165                 170                 175     


Ala Gln Asn Leu Leu Ala Gln Leu Pro Glu Glu Leu Phe His Pro Leu 
            180                 185                 190         


Thr Ser Leu Gln Thr Leu Lys Leu Ser Asn Asn Ala Leu Ser Gly Leu 
        195                 200                 205             


Pro Gln Gly Val Phe Gly Lys Leu Gly Ser Leu Gln Glu Leu Phe Leu 
    210                 215                 220                 


Asp Ser Asn Asn Ile Ser Glu Leu Pro Pro Gln Val Phe Ser Gln Leu 
225                 230                 235                 240 


Phe Cys Leu Glu Arg Leu Trp Leu Gln Arg Asn Ala Ile Thr His Leu 
                245                 250                 255     


Pro Leu Ser Ile Phe Ala Ser Leu Gly Asn Leu Thr Phe Leu Ser Leu 
            260                 265                 270         


Gln Trp Asn Met Leu Arg Val Leu Pro Ala Gly Leu Phe Ala His Thr 
        275                 280                 285             


Pro Cys Leu Val Gly Leu Ser Leu Thr His Asn Gln Leu Glu Thr Val 
    290                 295                 300                 


Ala Glu Gly Thr Phe Ala His Leu Ser Asn Leu Arg Ser Leu Met Leu 
305                 310                 315                 320 


Ser Tyr Asn Ala Ile Thr His Leu Pro Ala Gly Ile Phe Arg Asp Leu 
                325                 330                 335     


Glu Glu Leu Val Lys Leu Tyr Leu Gly Ser Asn Asn Leu Thr Ala Leu 
            340                 345                 350         


His Pro Ala Leu Phe Gln Asn Leu Ser Lys Leu Glu Leu Leu Ser Leu 
        355                 360                 365             


Ser Lys Asn Gln Leu Thr Thr Leu Pro Glu Gly Ile Phe Asp Thr Asn 
    370                 375                 380                 


Tyr Asn Leu Phe Asn Leu Ala Leu His Gly Asn Pro Trp Gln Cys Asp 
385                 390                 395                 400 


Cys His Leu Ala Tyr Leu Phe Asn Trp Leu Gln Gln Tyr Thr Asp Arg 
                405                 410                 415     


Leu Leu Asn Ile Gln Thr Tyr Cys Ala Gly Pro Ala Tyr Leu Lys Gly 
            420                 425                 430         


Gln Val Val Pro Ala Leu Asn Glu Lys Gln Leu Val Cys Pro Val Thr 
        435                 440                 445             


Arg Asp His Leu Gly Phe Gln Val Thr Trp Pro Asp Glu Ser Lys Ala 
    450                 455                 460                 


Gly Gly Ser Trp Asp Leu Ala Val Gln Glu Arg Ala Ala Arg Ser Gln 
465                 470                 475                 480 


Cys Thr Tyr Ser Asn Pro Glu Gly Thr Val Val Leu Ala Cys Asp Gln 
                485                 490                 495     


Ala Gln Cys Arg Trp Leu Asn Val Gln Leu Ser Pro Gln Gln Gly Ser 
            500                 505                 510         


Leu Gly Leu Gln Tyr Asn Ala Ser Gln Glu Trp Asp Leu Arg Ser Ser 
        515                 520                 525             


Cys Gly Ser Leu Arg Leu Thr Val Ser Ile Glu Ala Arg Ala Ala Gly 
    530                 535                 540                 


Pro 
545 


<210>  2526
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPNE1__Homo_sapiens__NP_001185792

<400>  2526

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15      


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30          


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45              


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60                  


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80  


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95      


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110         


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125             


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140                 


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160 


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175     


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190         


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205             


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220                 


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240 


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255     


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270         


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285             


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300                 


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320 


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335     


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350         


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365             


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380                 


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400 


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Tyr Phe Met Leu 
                405                 410                 415     


Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg Glu 
            420                 425                 430         


Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val Gly 
        435                 440                 445             


Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp Gly 
    450                 455                 460                 


Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile Val 
465                 470                 475                 480 


Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala Leu 
                485                 490                 495     


Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr Phe 
            500                 505                 510         


Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala Lys 
        515                 520                 525             


Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535     


<210>  2527
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPNE2__Homo_sapiens__NP_689940

<400>  2527

Met Ala His Ile Pro Ser Gly Gly Ala Pro Ala Ala Gly Ala Ala Pro 
1               5                   10                  15      


Met Gly Pro Gln Tyr Cys Val Cys Lys Val Glu Leu Ser Val Ser Gly 
            20                  25                  30          


Gln Asn Leu Leu Asp Arg Asp Val Thr Ser Lys Ser Asp Pro Phe Cys 
        35                  40                  45              


Val Leu Phe Thr Glu Asn Asn Gly Arg Trp Ile Glu Tyr Asp Arg Thr 
    50                  55                  60                  


Glu Thr Ala Ile Asn Asn Leu Asn Pro Ala Phe Ser Lys Lys Phe Val 
65                  70                  75                  80  


Leu Asp Tyr His Phe Glu Glu Val Gln Lys Leu Lys Phe Ala Leu Phe 
                85                  90                  95      


Asp Gln Asp Lys Ser Ser Met Arg Leu Asp Glu His Asp Phe Leu Gly 
            100                 105                 110         


Gln Phe Ser Cys Ser Leu Gly Thr Ile Val Ser Ser Lys Lys Ile Thr 
        115                 120                 125             


Arg Pro Leu Leu Leu Leu Asn Asp Lys Pro Ala Gly Lys Gly Leu Ile 
    130                 135                 140                 


Thr Ile Ala Ala Gln Glu Leu Ser Asp Asn Arg Val Ile Thr Leu Ser 
145                 150                 155                 160 


Leu Ala Gly Arg Arg Leu Asp Lys Lys Asp Leu Phe Gly Lys Ser Asp 
                165                 170                 175     


Pro Phe Leu Glu Phe Tyr Lys Pro Gly Asp Asp Gly Lys Trp Met Leu 
            180                 185                 190         


Val His Arg Thr Glu Val Ile Lys Tyr Thr Leu Asp Pro Val Trp Lys 
        195                 200                 205             


Pro Phe Thr Val Pro Leu Val Ser Leu Cys Asp Gly Asp Met Glu Lys 
    210                 215                 220                 


Pro Ile Gln Val Met Cys Tyr Asp Tyr Asp Asn Asp Gly Gly His Asp 
225                 230                 235                 240 


Phe Ile Gly Glu Phe Gln Thr Ser Val Ser Gln Met Cys Glu Ala Arg 
                245                 250                 255     


Asp Ser Val Pro Leu Glu Phe Glu Cys Ile Asn Pro Lys Lys Gln Arg 
            260                 265                 270         


Lys Lys Lys Asn Tyr Lys Asn Ser Gly Ile Ile Ile Leu Arg Ser Cys 
        275                 280                 285             


Lys Ile Asn Arg Asp Tyr Ser Phe Leu Asp Tyr Ile Leu Gly Gly Cys 
    290                 295                 300                 


Gln Leu Met Phe Thr Val Gly Ile Asp Phe Thr Ala Ser Asn Gly Asn 
305                 310                 315                 320 


Pro Leu Asp Pro Ser Ser Leu His Tyr Ile Asn Pro Met Gly Thr Asn 
                325                 330                 335     


Glu Tyr Leu Ser Ala Ile Trp Ala Val Gly Gln Ile Ile Gln Asp Tyr 
            340                 345                 350         


Asp Ser Asp Lys Met Phe Pro Ala Leu Gly Phe Gly Ala Gln Leu Pro 
        355                 360                 365             


Pro Asp Trp Lys Val Ser His Glu Phe Ala Ile Asn Phe Asn Pro Thr 
    370                 375                 380                 


Asn Pro Phe Cys Ser Gly Val Asp Gly Ile Ala Gln Ala Tyr Ser Ala 
385                 390                 395                 400 


Cys Leu Pro His Ile Arg Phe Tyr Gly Pro Thr Asn Phe Ser Pro Ile 
                405                 410                 415     


Val Asn His Val Ala Arg Phe Ala Ala Gln Ala Thr Gln Gln Arg Thr 
            420                 425                 430         


Ala Thr Gln Tyr Phe Ile Leu Leu Ile Ile Thr Asp Gly Val Ile Ser 
        435                 440                 445             


Asp Met Glu Glu Thr Arg His Ala Val Val Gln Ala Ser Lys Leu Pro 
    450                 455                 460                 


Met Ser Ile Ile Ile Val Gly Val Gly Asn Ala Asp Phe Ala Ala Met 
465                 470                 475                 480 


Glu Phe Leu Asp Gly Asp Ser Arg Met Leu Arg Ser His Thr Gly Glu 
                485                 490                 495     


Glu Ala Ala Arg Asp Ile Val Gln Phe Val Pro Phe Arg Glu Phe Arg 
            500                 505                 510         


Asn Ala Ala Lys Glu Thr Leu Ala Lys Ala Val Leu Ala Glu Leu Pro 
        515                 520                 525             


Gln Gln Val Val Gln Tyr Phe Lys His Lys Asn Leu Pro Pro Thr Asn 
    530                 535                 540                 


Ser Glu Pro Ala 
545             


<210>  2528
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPNE3__Homo_sapiens__NP_003900

<400>  2528

Met Ala Ala Gln Cys Val Thr Lys Val Ala Leu Asn Val Ser Cys Ala 
1               5                   10                  15      


Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val 
            20                  25                  30          


Leu Phe Leu Asn Thr Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Thr 
        35                  40                  45              


Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Thr Phe Ile 
    50                  55                  60                  


Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr 
65                  70                  75                  80  


Asp Ile Asp Asn Lys Thr Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly 
                85                  90                  95      


Glu Cys Glu Cys Thr Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Thr 
            100                 105                 110         


Arg Pro Leu Val Met Lys Thr Gly Arg Pro Ala Gly Lys Gly Ser Ile 
        115                 120                 125             


Thr Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu 
    130                 135                 140                 


Met Glu Ala Arg Lys Leu Asp Asn Lys Asp Leu Phe Gly Lys Ser Asp 
145                 150                 155                 160 


Pro Tyr Leu Glu Phe His Lys Gln Thr Ser Asp Gly Asn Trp Leu Met 
                165                 170                 175     


Val His Arg Thr Glu Val Val Lys Asn Asn Leu Asn Pro Val Trp Arg 
            180                 185                 190         


Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp Lys 
        195                 200                 205             


Thr Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His Asp 
    210                 215                 220                 


Leu Ile Gly Thr Phe Gln Thr Thr Met Thr Lys Leu Lys Glu Ala Ser 
225                 230                 235                 240 


Arg Ser Ser Pro Val Glu Phe Glu Cys Ile Asn Glu Lys Lys Arg Gln 
                245                 250                 255     


Lys Lys Lys Ser Tyr Lys Asn Ser Gly Val Ile Ser Val Lys Gln Cys 
            260                 265                 270         


Glu Ile Thr Val Glu Cys Thr Phe Leu Asp Tyr Ile Met Gly Gly Cys 
        275                 280                 285             


Gln Leu Asn Phe Thr Val Gly Val Asp Phe Thr Gly Ser Asn Gly Asp 
    290                 295                 300                 


Pro Arg Ser Pro Asp Ser Leu His Tyr Ile Ser Pro Asn Gly Val Asn 
305                 310                 315                 320 


Glu Tyr Leu Thr Ala Leu Trp Ser Val Gly Leu Val Ile Gln Asp Tyr 
                325                 330                 335     


Asp Ala Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Gln Ile Pro 
            340                 345                 350         


Pro Gln Trp Gln Val Ser His Glu Phe Pro Met Asn Phe Asn Pro Ser 
        355                 360                 365             


Asn Pro Tyr Cys Asn Gly Ile Gln Gly Ile Val Glu Ala Tyr Arg Ser 
    370                 375                 380                 


Cys Leu Pro Gln Ile Lys Leu Tyr Gly Pro Thr Asn Phe Ser Pro Ile 
385                 390                 395                 400 


Ile Asn His Val Ala Arg Phe Ala Ala Ala Ala Thr Gln Gln Gln Thr 
                405                 410                 415     


Ala Ser Gln Tyr Phe Val Leu Leu Ile Ile Thr Asp Gly Val Ile Thr 
            420                 425                 430         


Asp Leu Asp Glu Thr Arg Gln Ala Ile Val Asn Ala Ser Arg Leu Pro 
        435                 440                 445             


Met Ser Ile Ile Ile Val Gly Val Gly Gly Ala Asp Phe Ser Ala Met 
    450                 455                 460                 


Glu Phe Leu Asp Gly Asp Gly Gly Ser Leu Arg Ser Pro Leu Gly Glu 
465                 470                 475                 480 


Val Ala Ile Arg Asp Ile Val Gln Phe Val Pro Phe Arg Gln Phe Gln 
                485                 490                 495     


Asn Ala Pro Lys Glu Ala Leu Ala Gln Cys Val Leu Ala Glu Ile Pro 
            500                 505                 510         


Gln Gln Val Val Gly Tyr Phe Asn Thr Tyr Lys Leu Leu Pro Pro Lys 
        515                 520                 525             


Asn Pro Ala Thr Lys Gln Gln Lys Gln 
    530                 535         


<210>  2529
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPNE4__Homo_sapiens__NP_001276041

<400>  2529

Met Ala Val Glu Pro Ser Ser Ser Glu Ser Ile Lys Arg Arg Ala Gly 
1               5                   10                  15      


Arg Arg Met Lys Lys Met Ser Asn Ile Tyr Glu Ser Ala Ala Asn Thr 
            20                  25                  30          


Leu Gly Ile Phe Asn Ser Pro Cys Leu Thr Lys Val Glu Leu Arg Val 
        35                  40                  45              


Ala Cys Lys Gly Ile Ser Asp Arg Asp Ala Leu Ser Lys Pro Asp Pro 
    50                  55                  60                  


Cys Val Ile Leu Lys Met Gln Ser His Gly Gln Trp Phe Glu Val Asp 
65                  70                  75                  80  


Arg Thr Glu Val Ile Arg Thr Cys Ile Asn Pro Val Tyr Ser Lys Leu 
                85                  90                  95      


Phe Thr Val Asp Phe Tyr Phe Glu Glu Val Gln Arg Leu Arg Phe Glu 
            100                 105                 110         


Val His Asp Ile Ser Ser Asn His Asn Gly Leu Lys Glu Ala Asp Phe 
        115                 120                 125             


Leu Gly Gly Met Glu Cys Thr Leu Gly Gln Ile Val Ser Gln Arg Lys 
    130                 135                 140                 


Leu Ser Lys Ser Leu Leu Lys His Gly Asn Thr Ala Gly Lys Ser Ser 
145                 150                 155                 160 


Ile Thr Val Ile Ala Glu Glu Leu Ser Gly Asn Asp Asp Tyr Val Glu 
                165                 170                 175     


Leu Ala Phe Asn Ala Arg Lys Leu Asp Asp Lys Asp Phe Phe Ser Lys 
            180                 185                 190         


Ser Asp Pro Phe Leu Glu Ile Phe Arg Met Asn Asp Asp Ala Thr Gln 
        195                 200                 205             


Gln Leu Val His Arg Thr Glu Val Val Met Asn Asn Leu Ser Pro Ala 
    210                 215                 220                 


Trp Lys Ser Phe Lys Val Ser Val Asn Ser Leu Cys Ser Gly Asp Pro 
225                 230                 235                 240 


Asp Arg Arg Leu Lys Cys Ile Val Trp Asp Trp Asp Ser Asn Gly Lys 
                245                 250                 255     


His Asp Phe Ile Gly Glu Phe Thr Ser Thr Phe Lys Glu Met Arg Gly 
            260                 265                 270         


Ala Met Glu Gly Lys Gln Val Gln Trp Glu Cys Ile Asn Pro Lys Tyr 
        275                 280                 285             


Lys Ala Lys Lys Lys Asn Tyr Lys Asn Ser Gly Thr Val Ile Leu Asn 
    290                 295                 300                 


Leu Cys Lys Ile His Lys Met His Ser Phe Leu Asp Tyr Ile Met Gly 
305                 310                 315                 320 


Gly Cys Gln Ile Gln Phe Thr Val Ala Ile Asp Phe Thr Ala Ser Asn 
                325                 330                 335     


Gly Asp Pro Arg Asn Ser Cys Ser Leu His Tyr Ile His Pro Tyr Gln 
            340                 345                 350         


Pro Asn Glu Tyr Leu Lys Ala Leu Val Ala Val Gly Glu Ile Cys Gln 
        355                 360                 365             


Asp Tyr Asp Ser Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Arg 
    370                 375                 380                 


Ile Pro Pro Glu Tyr Thr Val Ser His Asp Phe Ala Ile Asn Phe Asn 
385                 390                 395                 400 


Glu Asp Asn Pro Glu Cys Ala Gly Ile Gln Gly Val Val Glu Ala Tyr 
                405                 410                 415     


Gln Ser Cys Leu Pro Lys Leu Gln Leu Tyr Gly Pro Thr Asn Ile Ala 
            420                 425                 430         


Pro Ile Ile Gln Lys Val Ala Lys Ser Ala Ser Glu Glu Thr Asn Thr 
        435                 440                 445             


Lys Glu Ala Ser Gln Tyr Phe Ile Leu Leu Ile Leu Thr Asp Gly Val 
    450                 455                 460                 


Ile Thr Asp Met Ala Asp Thr Arg Glu Ala Ile Val His Ala Ser His 
465                 470                 475                 480 


Leu Pro Met Ser Val Ile Ile Val Gly Val Gly Asn Ala Asp Phe Ser 
                485                 490                 495     


Asp Met Gln Met Leu Asp Gly Asp Asp Gly Ile Leu Arg Ser Pro Lys 
            500                 505                 510         


Gly Glu Pro Val Leu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asn 
        515                 520                 525             


Phe Lys His Ala Ser Pro Ala Ala Leu Ala Lys Ser Val Leu Ala Glu 
    530                 535                 540                 


Val Pro Asn Gln Val Val Asp Tyr Tyr Asn Gly Lys Gly Ile Lys Pro 
545                 550                 555                 560 


Lys Cys Ser Ser Glu Met Tyr Glu Ser Ser Arg Thr Leu Ala Pro 
                565                 570                 575 


<210>  2530
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPNE7__Homo_sapiens__NP_055242

<400>  2530

Met Ser Ala Gly Ser Glu Arg Gly Ala Ala Ala Thr Pro Gly Gly Leu 
1               5                   10                  15      


Pro Ala Pro Cys Ala Ser Lys Val Glu Leu Arg Leu Ser Cys Arg His 
            20                  25                  30          


Leu Leu Asp Arg Asp Pro Leu Thr Lys Ser Asp Pro Ser Val Ala Leu 
        35                  40                  45              


Leu Gln Gln Ala Gln Gly Gln Trp Val Gln Val Gly Arg Thr Glu Val 
    50                  55                  60                  


Val Arg Ser Ser Leu His Pro Val Phe Ser Lys Val Phe Thr Val Asp 
65                  70                  75                  80  


Tyr Tyr Phe Glu Glu Val Gln Arg Leu Arg Phe Glu Val Tyr Asp Thr 
                85                  90                  95      


His Gly Pro Ser Gly Phe Ser Cys Gln Glu Asp Asp Phe Leu Gly Gly 
            100                 105                 110         


Met Glu Cys Thr Leu Gly Gln Pro Ala Gln Lys Trp Leu Leu Gln Val 
        115                 120                 125             


Val Met Arg Val Ser Val Asp Val Leu Gly Pro Ala Gly His Cys Ala 
    130                 135                 140                 


Lys His Phe Leu Cys Cys Thr Glu Ser Ser His Leu Ala Arg Thr Gly 
145                 150                 155                 160 


Pro Ser Phe Leu Leu Arg Tyr Asp Asp Leu Cys Leu Pro Trp Ala Thr 
                165                 170                 175     


Ala Gly Ala Val Arg Trp Trp Thr Cys Arg Gly Gly His Thr Gln Gly 
            180                 185                 190         


Trp Gln Ile Val Ala Gln Lys Lys Val Thr Arg Pro Leu Leu Leu Lys 
        195                 200                 205             


Phe Gly Arg Asn Ala Gly Lys Ser Thr Ile Thr Val Ile Ala Glu Asp 
    210                 215                 220                 


Ile Ser Gly Asn Asn Gly Tyr Val Glu Leu Ser Phe Arg Ala Arg Lys 
225                 230                 235                 240 


Leu Asp Asp Lys Asp Leu Phe Ser Lys Ser Asp Pro Phe Leu Glu Leu 
                245                 250                 255     


Tyr Arg Val Asn Asp Asp Gln Gly Leu Gln Leu Val Tyr Arg Thr Glu 
            260                 265                 270         


Val Val Lys Asn Asn Leu Asn Pro Val Trp Glu Ala Phe Lys Val Ser 
        275                 280                 285             


Leu Ser Ser Leu Cys Ser Cys Glu Glu Thr Arg Pro Leu Lys Cys Leu 
    290                 295                 300                 


Val Trp Asp Tyr Asp Ser Arg Gly Lys His Asp Phe Ile Gly Glu Phe 
305                 310                 315                 320 


Ser Thr Thr Phe Glu Glu Met Gln Lys Ala Phe Glu Glu Gly Gln Ala 
                325                 330                 335     


Gln Trp Asp Cys Val Asn Pro Lys Tyr Lys Gln Lys Arg Arg Ser Tyr 
            340                 345                 350         


Lys Asn Ser Gly Val Val Val Leu Ala Asp Leu Lys Phe His Arg Val 
        355                 360                 365             


Tyr Ser Phe Leu Asp Tyr Ile Met Gly Gly Cys Gln Ile His Phe Thr 
    370                 375                 380                 


Val Ala Ile Asp Phe Thr Ala Ser Asn Gly Asp Pro Arg Asn Ser Cys 
385                 390                 395                 400 


Ser Leu His Tyr Ile Asn Pro Tyr Gln Pro Asn Glu Tyr Leu Lys Ala 
                405                 410                 415     


Leu Val Ser Val Gly Glu Ile Cys Gln Asp Tyr Asp Ser Asp Lys Arg 
            420                 425                 430         


Phe Ser Ala Leu Gly Phe Gly Ala Arg Ile Pro Pro Lys Tyr Glu Val 
        435                 440                 445             


Ser His Asp Phe Ala Ile Asn Phe Asn Pro Glu Asp Asp Glu Cys Glu 
    450                 455                 460                 


Gly Ile Gln Gly Val Val Glu Ala Tyr Gln Asn Cys Leu Pro Arg Val 
465                 470                 475                 480 


Gln Leu Tyr Gly Pro Thr Asn Val Ala Pro Ile Ile Ser Lys Val Ala 
                485                 490                 495     


Arg Val Ala Ala Ala Glu Glu Ser Thr Gly Lys Ala Ser Gln Tyr Tyr 
            500                 505                 510         


Ile Leu Leu Ile Leu Thr Asp Gly Val Val Thr Asp Met Ala Asp Thr 
        515                 520                 525             


Arg Glu Ala Ile Val Arg Ala Ser Arg Leu Pro Met Ser Ile Ile Ile 
    530                 535                 540                 


Val Gly Val Gly Asn Ala Asp Phe Thr Asp Met Gln Val Leu Asp Gly 
545                 550                 555                 560 


Asp Asp Gly Val Leu Arg Ser Pro Arg Gly Glu Pro Ala Leu Arg Asp 
                565                 570                 575     


Ile Val Gln Phe Val Pro Phe Arg Glu Leu Lys Asn Ala Ser Pro Ala 
            580                 585                 590         


Ala Leu Ala Lys Cys Val Leu Ala Glu Val Pro Lys Gln Val Val Glu 
        595                 600                 605             


Tyr Tyr Ser His Arg Gly Leu Pro Pro Arg Ser Leu Gly Val Pro Ala 
    610                 615                 620                 


Gly Glu Ala Ser Pro Gly Cys Thr Pro 
625                 630             


<210>  2531
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPNE8__Homo_sapiens__NP_705898

<400>  2531

Met Asp Ser Arg Tyr Asn Ser Thr Ala Gly Ile Gly Asp Leu Asn Gln 
1               5                   10                  15      


Leu Ser Ala Ala Ile Pro Ala Thr Arg Val Glu Val Ser Val Ser Cys 
            20                  25                  30          


Arg Asn Leu Leu Asp Arg Asp Thr Phe Ser Lys Ser Asp Pro Ile Cys 
        35                  40                  45              


Val Leu Tyr Val Gln Gly Val Gly Asn Lys Glu Trp Arg Glu Phe Gly 
    50                  55                  60                  


Arg Thr Glu Val Ile Asp Asn Thr Leu Asn Pro Asp Phe Val Arg Lys 
65                  70                  75                  80  


Phe Ile Leu Asp Tyr Phe Phe Glu Glu Arg Glu Asn Leu Arg Phe Asp 
                85                  90                  95      


Leu Tyr Asp Val Asp Ser Lys Ser Pro Asn Leu Ser Lys His Asp Phe 
            100                 105                 110         


Leu Gly Gln Val Phe Cys Thr Leu Gly Glu Ile Val Gly Ser Gln Gly 
        115                 120                 125             


Ser Arg Leu Glu Lys Pro Ile Val Gly Ile Pro Gly Lys Lys Cys Gly 
    130                 135                 140                 


Thr Ile Ile Leu Thr Ala Glu Glu Leu Asn Cys Cys Arg Asp Ala Val 
145                 150                 155                 160 


Leu Met Gln Phe Cys Ala Asn Lys Leu Asp Lys Lys Asp Phe Phe Gly 
                165                 170                 175     


Lys Ser Asp Pro Phe Leu Val Phe Tyr Arg Ser Asn Glu Asp Gly Ser 
            180                 185                 190         


Phe Thr Ile Cys His Lys Thr Glu Val Val Lys Asn Thr Leu Asn Pro 
        195                 200                 205             


Val Trp Gln Ala Phe Lys Ile Ser Val Arg Ala Leu Cys Asn Gly Asp 
    210                 215                 220                 


Tyr Asp Arg Thr Ile Lys Val Glu Val Tyr Asp Trp Asp Arg Asp Gly 
225                 230                 235                 240 


Ser His Asp Phe Ile Gly Glu Phe Thr Thr Ser Tyr Arg Glu Leu Ser 
                245                 250                 255     


Arg Gly Gln Ser Gln Phe Asn Val Tyr Glu Val Val Asn Pro Lys Lys 
            260                 265                 270         


Lys Gly Lys Lys Lys Lys Tyr Thr Asn Ser Gly Thr Val Thr Leu Leu 
        275                 280                 285             


Ser Phe Leu Val Glu Thr Glu Val Ser Phe Leu Asp Tyr Ile Lys Gly 
    290                 295                 300                 


Gly Thr Gln Ile Asn Phe Thr Val Ala Ile Asp Phe Thr Ala Ser Asn 
305                 310                 315                 320 


Gly Asn Pro Ala Gln Pro Thr Ser Leu His Tyr Met Asn Pro Tyr Gln 
                325                 330                 335     


Leu Asn Ala Tyr Gly Met Ala Leu Lys Ala Val Gly Glu Ile Val Gln 
            340                 345                 350         


Asp Tyr Asp Ser Asp Lys Met Phe Pro Ala Leu Gly Phe Gly Ala Lys 
        355                 360                 365             


Leu Pro Pro Asp Gly Arg Ile Ser His Glu Phe Ala Leu Asn Gly Asn 
    370                 375                 380                 


Pro Gln Asn Pro Tyr Cys Asp Gly Ile Glu Gly Val Met Glu Ala Tyr 
385                 390                 395                 400 


Tyr Arg Ser Leu Lys Ser Val Gln Leu Tyr Gly Pro Thr Asn Phe Ala 
                405                 410                 415     


Pro Val Ile Asn His Val Ala Arg Tyr Ala Ser Ser Val Lys Asp Gly 
            420                 425                 430         


Ser Gln Tyr Phe Val Leu Leu Ile Val Thr Asp Gly Val Ile Ser Asp 
        435                 440                 445             


Met Ala Gln Thr Lys Glu Ser Ile Val Asn Ala Ser Lys Leu Pro Met 
    450                 455                 460                 


Ser Ile Ile Ile Val Gly Val Gly Pro Ala Glu Phe Asp Ala Met Val 
465                 470                 475                 480 


Glu Leu Asp Gly Asp Asp Val Arg Val Ser Ser Arg Gly Lys Tyr Ala 
                485                 490                 495     


Glu Arg Asp Ile Val Gln Phe Val Pro Phe Arg Asp Tyr Ile Asp Arg 
            500                 505                 510         


Ser Gly Asn His Ile Leu Ser Met Ala Arg Leu Ala Lys Asp Val Leu 
        515                 520                 525             


Ala Glu Ile Pro Glu Gln Phe Leu Ser Tyr Met Arg Ala Arg Gly Ile 
    530                 535                 540                 


Lys Pro Ser Pro Ala Pro Pro Pro Tyr Thr Pro Pro Thr His Val Leu 
545                 550                 555                 560 


Gln Thr Gln Ile 
                


<210>  2532
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPO__Homo_sapiens__XP_011508929

<400>  2532

Met Lys Pro Leu Leu Glu Thr Leu Tyr Leu Leu Gly Met Leu Val Pro 
1               5                   10                  15      


Gly Gly Leu Gly Tyr Asp Arg Ser Leu Ala Gln His Arg Gln Glu Ile 
            20                  25                  30          


Val Asp Lys Ser Val Ser Pro Trp Ser Leu Glu Thr Tyr Ser Tyr Asn 
        35                  40                  45              


Ile Tyr His Pro Met Gly Glu Ile Tyr Glu Trp Met Arg Glu Ile Ser 
    50                  55                  60                  


Glu Lys Tyr Lys Glu Val Val Thr Gln His Phe Leu Gly Val Thr Tyr 
65                  70                  75                  80  


Glu Thr His Pro Met Tyr Tyr Leu Lys Ile Ser Gln Pro Ser Gly Asn 
                85                  90                  95      


Pro Lys Lys Ile Ile Trp Met Asp Cys Gly Ile His Ala Arg Glu Trp 
            100                 105                 110         


Ile Ala Pro Ala Phe Cys Gln Trp Phe Val Lys Glu Ile Leu Gln Asn 
        115                 120                 125             


His Lys Asp Asn Ser Ser Ile Arg Lys Leu Leu Arg Asn Leu Asp Phe 
    130                 135                 140                 


Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr 
145                 150                 155                 160 


Thr Asp Arg Leu Trp Arg Lys Ser Arg Ser Pro His Asn Asn Gly Thr 
                165                 170                 175     


Cys Phe Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Cys Ser 
            180                 185                 190         


Ile Gly Ala Ser Arg Asn Cys Gln Asp Gln Thr Phe Cys Gly Thr Gly 
        195                 200                 205             


Pro Val Ser Glu Pro Glu Thr Lys Ala Val Ala Ser Phe Ile Glu Ser 
    210                 215                 220                 


Lys Lys Asp Asp Ile Leu Cys Phe Leu Thr Met His Ser Tyr Gly Gln 
225                 230                 235                 240 


Leu Ile Leu Thr Pro Tyr Gly Tyr Thr Lys Asn Lys Ser Ser Asn His 
                245                 250                 255     


Pro Glu Met Ile Gln Val Gly Gln Lys Ala Ala Asn Ala Leu Lys Ala 
            260                 265                 270         


Lys Tyr Gly Thr Asn Tyr Arg Val Gly Ser Ser Ala Asp Ile Leu Tyr 
        275                 280                 285             


Ala Ser Ser Gly Ser Ser Arg Asp Trp Ala Arg Asp Ile Gly Ile Pro 
    290                 295                 300                 


Phe Ser Tyr Thr Phe Glu Leu Arg Asp Ser Gly Thr Tyr Gly Phe Val 
305                 310                 315                 320 


Leu Pro Glu Ala Gln Ile Gln Pro Thr Cys Glu Glu Thr Met Glu Ala 
                325                 330                 335     


Val Leu Ser Val Leu Asp Asp Val Tyr Ala Lys His Trp His Ser Asp 
            340                 345                 350         


Ser Ala Gly Arg Val Thr Ser Ala Thr Met Leu Leu Gly Leu Leu Val 
        355                 360                 365             


Ser Cys Met Ser Leu Leu 
    370                 


<210>  2533
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPOX__Homo_sapiens__NP_000088

<400>  2533

Met Ala Leu Gln Leu Gly Arg Leu Ser Ser Gly Pro Cys Trp Leu Val 
1               5                   10                  15      


Ala Arg Gly Gly Cys Gly Gly Pro Arg Ala Trp Ser Gln Cys Gly Gly 
            20                  25                  30          


Gly Gly Leu Arg Ala Trp Ser Gln Arg Ser Ala Ala Gly Arg Val Cys 
        35                  40                  45              


Arg Pro Pro Gly Pro Ala Gly Thr Glu Gln Ser Arg Gly Leu Gly His 
    50                  55                  60                  


Gly Ser Thr Ser Arg Gly Gly Pro Trp Val Gly Thr Gly Leu Ala Ala 
65                  70                  75                  80  


Ala Leu Ala Gly Leu Val Gly Leu Ala Thr Ala Ala Phe Gly His Val 
                85                  90                  95      


Gln Arg Ala Glu Met Leu Pro Lys Thr Ser Gly Thr Arg Ala Thr Ser 
            100                 105                 110         


Leu Gly Arg Pro Glu Glu Glu Glu Asp Glu Leu Ala His Arg Cys Ser 
        115                 120                 125             


Ser Phe Met Ala Pro Pro Val Thr Asp Leu Gly Glu Leu Arg Arg Arg 
    130                 135                 140                 


Pro Gly Asp Met Lys Thr Lys Met Glu Leu Leu Ile Leu Glu Thr Gln 
145                 150                 155                 160 


Ala Gln Val Cys Gln Ala Leu Ala Gln Val Asp Gly Gly Ala Asn Phe 
                165                 170                 175     


Ser Val Asp Arg Trp Glu Arg Lys Glu Gly Gly Gly Gly Ile Ser Cys 
            180                 185                 190         


Val Leu Gln Asp Gly Cys Val Phe Glu Lys Ala Gly Val Ser Ile Ser 
        195                 200                 205             


Val Val His Gly Asn Leu Ser Glu Glu Ala Ala Lys Gln Met Arg Ser 
    210                 215                 220                 


Arg Gly Lys Val Leu Lys Thr Lys Asp Gly Lys Leu Pro Phe Cys Ala 
225                 230                 235                 240 


Met Gly Val Ser Ser Val Ile His Pro Lys Asn Pro His Ala Pro Thr 
                245                 250                 255     


Ile His Phe Asn Tyr Arg Tyr Phe Glu Val Glu Glu Ala Asp Gly Asn 
            260                 265                 270         


Lys Gln Trp Trp Phe Gly Gly Gly Cys Asp Leu Thr Pro Thr Tyr Leu 
        275                 280                 285             


Asn Gln Glu Asp Ala Val His Phe His Arg Thr Leu Lys Glu Ala Cys 
    290                 295                 300                 


Asp Gln His Gly Pro Asp Leu Tyr Pro Lys Phe Lys Lys Trp Cys Asp 
305                 310                 315                 320 


Asp Tyr Phe Phe Ile Ala His Arg Gly Glu Arg Arg Gly Ile Gly Gly 
                325                 330                 335     


Ile Phe Phe Asp Asp Leu Asp Ser Pro Ser Lys Glu Glu Val Phe Arg 
            340                 345                 350         


Phe Val Gln Ser Cys Ala Arg Ala Val Val Pro Ser Tyr Ile Pro Leu 
        355                 360                 365             


Val Lys Lys His Cys Asp Asp Ser Phe Thr Pro Gln Glu Lys Leu Trp 
    370                 375                 380                 


Gln Gln Leu Arg Arg Gly Arg Tyr Val Glu Phe Asn Leu Leu Tyr Asp 
385                 390                 395                 400 


Arg Gly Thr Lys Phe Gly Leu Phe Thr Pro Gly Ser Arg Ile Glu Ser 
                405                 410                 415     


Ile Leu Met Ser Leu Pro Leu Thr Ala Arg Trp Glu Tyr Met His Ser 
            420                 425                 430         


Pro Ser Glu Asn Ser Lys Glu Ala Glu Ile Leu Glu Val Leu Arg His 
        435                 440                 445             


Pro Arg Asp Trp Val Arg 
    450                 


<210>  2534
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPPED1__Homo_sapiens__NP_001092925

<400>  2534

Met Ser Ala Ala Glu Ala Gly Gly Val Phe His Arg Ala Arg Gly Arg 
1               5                   10                  15      


Thr Leu Ala Ala Phe Pro Ala Glu Lys Glu Ser Glu Trp Lys Gly Pro 
            20                  25                  30          


Phe Tyr Phe Ile Leu Gly Ala Asp Pro Gln Phe Gly Leu Ile Lys Ala 
        35                  40                  45              


Trp Ser Thr Gly Asp Cys Asp Asn Gly Gly Asp Glu Trp Glu Gln Glu 
    50                  55                  60                  


Ile Arg Leu Thr Glu Gln Ala Val Gln Ala Ile Asn Lys Leu Asn Pro 
65                  70                  75                  80  


Lys Pro Lys Phe Phe Val Leu Cys Gly Asp Leu Ile His Ala Met Pro 
                85                  90                  95      


Gly Val Lys Val Val Phe Ser Gly His Tyr His Arg Asn Ala Gly Gly 
            100                 105                 110         


Thr Tyr Gln Asn Leu Asp Met Val Val Ser Ser Ala Ile Gly Cys Gln 
        115                 120                 125             


Leu Gly Arg Asp Pro His Gly Leu Arg Val Val Val Val Thr Ala Glu 
    130                 135                 140                 


Lys Ile Val His Arg Tyr Tyr Ser Leu Asp Glu Leu Ser Glu Lys Gly 
145                 150                 155                 160 


Ile Glu Asp Asp Leu Met Asp Leu Ile Lys Lys Lys 
                165                 170         


<210>  2535
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPQ__Homo_sapiens__NP_057218

<400>  2535

Met Lys Phe Leu Ile Phe Ala Phe Phe Gly Gly Val His Leu Leu Ser 
1               5                   10                  15      


Leu Cys Ser Gly Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr 
            20                  25                  30          


Phe Glu Glu Ile Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys 
        35                  40                  45              


Ala Ile Ile Asn Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr 
    50                  55                  60                  


Glu Arg Leu Ala Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly 
65                  70                  75                  80  


Ser Lys Asn Leu Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln 
                85                  90                  95      


Gln Asp Gly Leu Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His 
            100                 105                 110         


Trp Glu Arg Gly Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His 
        115                 120                 125             


Lys Ile Ala Ile Leu Gly Leu Gly Ser Ser Ile Gly Thr Pro Pro Glu 
    130                 135                 140                 


Gly Ile Thr Ala Glu Val Leu Val Val Thr Ser Phe Asp Glu Leu Gln 
145                 150                 155                 160 


Arg Arg Ala Ser Glu Ala Arg Gly Lys Ile Val Val Tyr Asn Gln Pro 
                165                 170                 175     


Tyr Ile Asn Tyr Ser Arg Thr Val Gln Tyr Arg Thr Gln Gly Ala Val 
            180                 185                 190         


Glu Ala Ala Lys Val Gly Ala Leu Ala Ser Leu Ile Arg Ser Val Ala 
        195                 200                 205             


Ser Phe Ser Ile Tyr Ser Pro His Thr Gly Ile Gln Glu Tyr Gln Asp 
    210                 215                 220                 


Gly Val Pro Lys Ile Pro Thr Ala Cys Ile Thr Val Glu Asp Ala Glu 
225                 230                 235                 240 


Met Met Ser Arg Met Ala Ser His Gly Ile Lys Ile Val Ile Gln Leu 
                245                 250                 255     


Lys Met Gly Ala Lys Thr Tyr Pro Asp Thr Asp Ser Phe Asn Thr Val 
            260                 265                 270         


Ala Glu Ile Thr Gly Ser Lys Tyr Pro Glu Gln Val Val Leu Val Ser 
        275                 280                 285             


Gly His Leu Asp Ser Trp Asp Val Gly Gln Gly Ala Met Asp Asp Gly 
    290                 295                 300                 


Gly Gly Ala Phe Ile Ser Trp Glu Ala Leu Ser Leu Ile Lys Asp Leu 
305                 310                 315                 320 


Gly Leu Arg Pro Lys Arg Thr Leu Arg Leu Val Leu Trp Thr Ala Glu 
                325                 330                 335     


Glu Gln Gly Gly Val Gly Ala Phe Gln Tyr Tyr Gln Leu His Lys Val 
            340                 345                 350         


Asn Ile Ser Asn Tyr Ser Leu Val Met Glu Ser Asp Ala Gly Thr Phe 
        355                 360                 365             


Leu Pro Thr Gly Leu Gln Phe Thr Gly Ser Glu Lys Ala Arg Ala Ile 
    370                 375                 380                 


Met Glu Glu Val Met Ser Leu Leu Gln Pro Leu Asn Ile Thr Gln Val 
385                 390                 395                 400 


Leu Ser His Gly Glu Gly Thr Asp Ile Asn Phe Trp Ile Gln Ala Gly 
                405                 410                 415     


Val Pro Gly Ala Ser Leu Leu Asp Asp Leu Tyr Lys Tyr Phe Phe Phe 
            420                 425                 430         


His His Ser His Gly Asp Thr Met Thr Val Met Asp Pro Lys Gln Met 
        435                 440                 445             


Asn Val Ala Ala Ala Val Trp Ala Val Val Ser Tyr Val Val Ala Asp 
    450                 455                 460                 


Met Glu Glu Met Leu Pro Arg Ser 
465                 470         


<210>  2536
<211>  1506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPS1__Homo_sapiens__NP_001116105

<400>  2536

Met Pro Gln Ile Ile Lys Met Thr Arg Ile Leu Thr Ala Phe Lys Val 
1               5                   10                  15      


Val Arg Thr Leu Lys Thr Gly Phe Gly Phe Thr Asn Val Thr Ala His 
            20                  25                  30          


Gln Lys Trp Lys Phe Ser Arg Pro Gly Ile Arg Leu Leu Ser Val Lys 
        35                  40                  45              


Ala Gln Thr Ala His Ile Val Leu Glu Asp Gly Thr Lys Met Lys Gly 
    50                  55                  60                  


Tyr Ser Phe Gly His Pro Ser Ser Val Ala Gly Glu Val Val Phe Asn 
65                  70                  75                  80  


Thr Gly Leu Gly Gly Tyr Pro Glu Ala Ile Thr Asp Pro Ala Tyr Lys 
                85                  90                  95      


Gly Gln Ile Leu Thr Met Ala Asn Pro Ile Ile Gly Asn Gly Gly Ala 
            100                 105                 110         


Pro Asp Thr Thr Ala Leu Asp Glu Leu Gly Leu Ser Lys Tyr Leu Glu 
        115                 120                 125             


Ser Asn Gly Ile Lys Val Ser Gly Leu Leu Val Leu Asp Tyr Ser Lys 
    130                 135                 140                 


Asp Tyr Asn His Trp Leu Ala Thr Lys Ser Leu Gly Gln Trp Leu Gln 
145                 150                 155                 160 


Glu Glu Lys Val Pro Ala Ile Tyr Gly Val Asp Thr Arg Met Leu Thr 
                165                 170                 175     


Lys Ile Ile Arg Asp Lys Gly Thr Met Leu Gly Lys Ile Glu Phe Glu 
            180                 185                 190         


Gly Gln Pro Val Asp Phe Val Asp Pro Asn Lys Gln Asn Leu Ile Ala 
        195                 200                 205             


Glu Val Ser Thr Lys Asp Val Lys Val Tyr Gly Lys Gly Asn Pro Thr 
    210                 215                 220                 


Lys Val Val Ala Val Asp Cys Gly Ile Lys Asn Asn Val Ile Arg Leu 
225                 230                 235                 240 


Leu Val Lys Arg Gly Ala Glu Val His Leu Val Pro Trp Asn His Asp 
                245                 250                 255     


Phe Thr Lys Met Glu Tyr Asp Gly Ile Leu Ile Ala Gly Gly Pro Gly 
            260                 265                 270         


Asn Pro Ala Leu Ala Glu Pro Leu Ile Gln Asn Val Arg Lys Ile Leu 
        275                 280                 285             


Glu Ser Asp Arg Lys Glu Pro Leu Phe Gly Ile Ser Thr Gly Asn Leu 
    290                 295                 300                 


Ile Thr Gly Leu Ala Ala Gly Ala Lys Thr Tyr Lys Met Ser Met Ala 
305                 310                 315                 320 


Asn Arg Gly Gln Asn Gln Pro Val Leu Asn Ile Thr Asn Lys Gln Ala 
                325                 330                 335     


Phe Ile Thr Ala Gln Asn His Gly Tyr Ala Leu Asp Asn Thr Leu Pro 
            340                 345                 350         


Ala Gly Trp Lys Pro Leu Phe Val Asn Val Asn Asp Gln Thr Asn Glu 
        355                 360                 365             


Gly Ile Met His Glu Ser Lys Pro Phe Phe Ala Val Gln Phe His Pro 
    370                 375                 380                 


Glu Val Thr Pro Gly Pro Ile Asp Thr Glu Tyr Leu Phe Asp Ser Phe 
385                 390                 395                 400 


Phe Ser Leu Ile Lys Lys Gly Lys Ala Thr Thr Ile Thr Ser Val Leu 
                405                 410                 415     


Pro Lys Pro Ala Leu Val Ala Ser Arg Val Glu Val Ser Lys Val Leu 
            420                 425                 430         


Ile Leu Gly Ser Gly Gly Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp 
        435                 440                 445             


Tyr Ser Gly Ser Gln Ala Val Lys Ala Met Lys Glu Glu Asn Val Lys 
    450                 455                 460                 


Thr Val Leu Met Asn Pro Asn Ile Ala Ser Val Gln Thr Asn Glu Val 
465                 470                 475                 480 


Gly Leu Lys Gln Ala Asp Thr Val Tyr Phe Leu Pro Ile Thr Pro Gln 
                485                 490                 495     


Phe Val Thr Glu Val Ile Lys Ala Glu Gln Pro Asp Gly Leu Ile Leu 
            500                 505                 510         


Gly Met Gly Gly Gln Thr Ala Leu Asn Cys Gly Val Glu Leu Phe Lys 
        515                 520                 525             


Arg Gly Val Leu Lys Glu Tyr Gly Val Lys Val Leu Gly Thr Ser Val 
    530                 535                 540                 


Glu Ser Ile Met Ala Thr Glu Asp Arg Gln Leu Phe Ser Asp Lys Leu 
545                 550                 555                 560 


Asn Glu Ile Asn Glu Lys Ile Ala Pro Ser Phe Ala Val Glu Ser Ile 
                565                 570                 575     


Glu Asp Ala Leu Lys Ala Ala Asp Thr Ile Gly Tyr Pro Val Met Ile 
            580                 585                 590         


Arg Ser Ala Tyr Ala Leu Gly Gly Leu Gly Ser Gly Ile Cys Pro Asn 
        595                 600                 605             


Arg Glu Thr Leu Met Asp Leu Ser Thr Lys Ala Phe Ala Met Thr Asn 
    610                 615                 620                 


Gln Ile Leu Val Glu Lys Ser Val Thr Gly Trp Lys Glu Ile Glu Tyr 
625                 630                 635                 640 


Glu Val Val Arg Asp Ala Asp Asp Asn Cys Val Thr Val Cys Asn Met 
                645                 650                 655     


Glu Asn Val Asp Ala Met Gly Val His Thr Gly Asp Ser Val Val Val 
            660                 665                 670         


Ala Pro Ala Gln Thr Leu Ser Asn Ala Glu Phe Gln Met Leu Arg Arg 
        675                 680                 685             


Thr Ser Ile Asn Val Val Arg His Leu Gly Ile Val Gly Glu Cys Asn 
    690                 695                 700                 


Ile Gln Phe Ala Leu His Pro Thr Ser Met Glu Tyr Cys Ile Ile Glu 
705                 710                 715                 720 


Val Asn Ala Arg Leu Ser Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr 
                725                 730                 735     


Gly Tyr Pro Leu Ala Phe Ile Ala Ala Lys Ile Ala Leu Gly Ile Pro 
            740                 745                 750         


Leu Pro Glu Ile Lys Asn Val Val Ser Gly Lys Thr Ser Ala Cys Phe 
        755                 760                 765             


Glu Pro Ser Leu Asp Tyr Met Val Thr Lys Ile Pro Arg Trp Asp Leu 
    770                 775                 780                 


Asp Arg Phe His Gly Thr Ser Ser Arg Ile Gly Ser Ser Met Lys Ser 
785                 790                 795                 800 


Val Gly Glu Val Met Ala Ile Gly Arg Thr Phe Glu Glu Ser Phe Gln 
                805                 810                 815     


Lys Ala Leu Arg Met Cys His Pro Ser Ile Glu Gly Phe Thr Pro Arg 
            820                 825                 830         


Leu Pro Met Asn Lys Glu Trp Pro Ser Asn Leu Asp Leu Arg Lys Glu 
        835                 840                 845             


Leu Ser Glu Pro Ser Ser Thr Arg Ile Tyr Ala Ile Ala Lys Ala Ile 
    850                 855                 860                 


Asp Asp Asn Met Ser Leu Asp Glu Ile Glu Lys Leu Thr Tyr Ile Asp 
865                 870                 875                 880 


Lys Trp Phe Leu Tyr Lys Met Arg Asp Ile Leu Asn Met Glu Lys Thr 
                885                 890                 895     


Leu Lys Gly Leu Asn Ser Glu Ser Met Thr Glu Glu Thr Leu Lys Arg 
            900                 905                 910         


Ala Lys Glu Ile Gly Phe Ser Asp Lys Gln Ile Ser Lys Cys Leu Gly 
        915                 920                 925             


Leu Thr Glu Ala Gln Thr Arg Glu Leu Arg Leu Lys Lys Asn Ile His 
    930                 935                 940                 


Pro Trp Val Lys Gln Ile Asp Thr Leu Ala Ala Glu Tyr Pro Ser Val 
945                 950                 955                 960 


Thr Asn Tyr Leu Tyr Val Thr Tyr Asn Gly Gln Glu His Asp Val Asn 
                965                 970                 975     


Phe Asp Asp His Gly Met Met Val Leu Gly Cys Gly Pro Tyr His Ile 
            980                 985                 990         


Gly Ser Ser Val Glu Phe Asp Trp  Cys Ala Val Ser Ser  Ile Arg Thr 
        995                 1000                 1005             


Leu Arg  Gln Leu Gly Lys Lys  Thr Val Val Val Asn  Cys Asn Pro 
    1010                 1015                 1020             


Glu Thr  Val Ser Thr Asp Phe  Asp Glu Cys Asp Lys  Leu Tyr Phe 
    1025                 1030                 1035             


Glu Glu  Leu Ser Leu Glu Arg  Ile Leu Asp Ile Tyr  His Gln Glu 
    1040                 1045                 1050             


Ala Cys  Gly Gly Cys Ile Ile  Ser Val Gly Gly Gln  Ile Pro Asn 
    1055                 1060                 1065             


Asn Leu  Ala Val Pro Leu Tyr  Lys Asn Gly Val Lys  Ile Met Gly 
    1070                 1075                 1080             


Thr Ser  Pro Leu Gln Ile Asp  Arg Ala Glu Asp Arg  Ser Ile Phe 
    1085                 1090                 1095             


Ser Ala  Val Leu Asp Glu Leu  Lys Val Ala Gln Ala  Pro Trp Lys 
    1100                 1105                 1110             


Ala Val  Asn Thr Leu Asn Glu  Ala Leu Glu Phe Ala  Lys Ser Val 
    1115                 1120                 1125             


Asp Tyr  Pro Cys Leu Leu Arg  Pro Ser Tyr Val Leu  Ser Gly Ser 
    1130                 1135                 1140             


Ala Met  Asn Val Val Phe Ser  Glu Asp Glu Met Lys  Lys Phe Leu 
    1145                 1150                 1155             


Glu Glu  Ala Thr Arg Val Ser  Gln Glu His Pro Val  Val Leu Thr 
    1160                 1165                 1170             


Lys Phe  Val Glu Gly Ala Arg  Glu Val Glu Met Asp  Ala Val Gly 
    1175                 1180                 1185             


Lys Asp  Gly Arg Val Ile Ser  His Ala Ile Ser Glu  His Val Glu 
    1190                 1195                 1200             


Asp Ala  Gly Val His Ser Gly  Asp Ala Thr Leu Met  Leu Pro Thr 
    1205                 1210                 1215             


Gln Thr  Ile Ser Gln Gly Ala  Ile Glu Lys Val Lys  Asp Ala Thr 
    1220                 1225                 1230             


Arg Lys  Ile Ala Lys Ala Phe  Ala Ile Ser Gly Pro  Phe Asn Val 
    1235                 1240                 1245             


Gln Phe  Leu Val Lys Gly Asn  Asp Val Leu Val Ile  Glu Cys Asn 
    1250                 1255                 1260             


Leu Arg  Ala Ser Arg Ser Phe  Pro Phe Val Ser Lys  Thr Leu Gly 
    1265                 1270                 1275             


Val Asp  Phe Ile Asp Val Ala  Thr Lys Val Met Ile  Gly Glu Asn 
    1280                 1285                 1290             


Val Asp  Glu Lys His Leu Pro  Thr Leu Asp His Pro  Ile Ile Pro 
    1295                 1300                 1305             


Ala Asp  Tyr Val Ala Ile Lys  Ala Pro Met Phe Ser  Trp Pro Arg 
    1310                 1315                 1320             


Leu Arg  Asp Ala Asp Pro Ile  Leu Arg Cys Glu Met  Ala Ser Thr 
    1325                 1330                 1335             


Gly Glu  Val Ala Cys Phe Gly  Glu Gly Ile His Thr  Ala Phe Leu 
    1340                 1345                 1350             


Lys Ala  Met Leu Ser Thr Gly  Phe Lys Ile Pro Gln  Lys Gly Ile 
    1355                 1360                 1365             


Leu Ile  Gly Ile Gln Gln Ser  Phe Arg Pro Arg Phe  Leu Gly Val 
    1370                 1375                 1380             


Ala Glu  Gln Leu His Asn Glu  Gly Phe Lys Leu Phe  Ala Thr Glu 
    1385                 1390                 1395             


Ala Thr  Ser Asp Trp Leu Asn  Ala Asn Asn Val Pro  Ala Thr Pro 
    1400                 1405                 1410             


Val Ala  Trp Pro Ser Gln Glu  Gly Gln Asn Pro Ser  Leu Ser Ser 
    1415                 1420                 1425             


Ile Arg  Lys Leu Ile Arg Asp  Gly Ser Ile Asp Leu  Val Ile Asn 
    1430                 1435                 1440             


Leu Pro  Asn Asn Asn Thr Lys  Phe Val His Asp Asn  Tyr Val Ile 
    1445                 1450                 1455             


Arg Arg  Thr Ala Val Asp Ser  Gly Ile Pro Leu Leu  Thr Asn Phe 
    1460                 1465                 1470             


Gln Val  Thr Lys Leu Phe Ala  Glu Ala Val Gln Lys  Ser Arg Lys 
    1475                 1480                 1485             


Val Asp  Ser Lys Ser Leu Phe  His Tyr Arg Gln Tyr  Ser Ala Gly 
    1490                 1495                 1500             


Lys Ala  Ala 
    1505     


<210>  2537
<211>  1443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPSF1__Homo_sapiens__NP_037423

<400>  2537

Met Tyr Ala Val Tyr Lys Gln Ala His Pro Pro Thr Gly Leu Glu Phe 
1               5                   10                  15      


Ser Met Tyr Cys Asn Phe Phe Asn Asn Ser Glu Arg Asn Leu Val Val 
            20                  25                  30          


Ala Gly Thr Ser Gln Leu Tyr Val Tyr Arg Leu Asn Arg Asp Ala Glu 
        35                  40                  45              


Ala Leu Thr Lys Asn Asp Arg Ser Thr Glu Gly Lys Ala His Arg Glu 
    50                  55                  60                  


Lys Leu Glu Leu Ala Ala Ser Phe Ser Phe Phe Gly Asn Val Met Ser 
65                  70                  75                  80  


Met Ala Ser Val Gln Leu Ala Gly Ala Lys Arg Asp Ala Leu Leu Leu 
                85                  90                  95      


Ser Phe Lys Asp Ala Lys Leu Ser Val Val Glu Tyr Asp Pro Gly Thr 
            100                 105                 110         


His Asp Leu Lys Thr Leu Ser Leu His Tyr Phe Glu Glu Pro Glu Leu 
        115                 120                 125             


Arg Asp Gly Phe Val Gln Asn Val His Thr Pro Arg Val Arg Val Asp 
    130                 135                 140                 


Pro Asp Gly Arg Cys Ala Ala Met Leu Val Tyr Gly Thr Arg Leu Val 
145                 150                 155                 160 


Val Leu Pro Phe Arg Arg Glu Ser Leu Ala Glu Glu His Glu Gly Leu 
                165                 170                 175     


Val Gly Glu Gly Gln Arg Ser Ser Phe Leu Pro Ser Tyr Ile Ile Asp 
            180                 185                 190         


Val Arg Ala Leu Asp Glu Lys Leu Leu Asn Ile Ile Asp Leu Gln Phe 
        195                 200                 205             


Leu His Gly Tyr Tyr Glu Pro Thr Leu Leu Ile Leu Phe Glu Pro Asn 
    210                 215                 220                 


Gln Thr Trp Pro Gly Arg Val Ala Val Arg Gln Asp Thr Cys Ser Ile 
225                 230                 235                 240 


Val Ala Ile Ser Leu Asn Ile Thr Gln Lys Val His Pro Val Ile Trp 
                245                 250                 255     


Ser Leu Thr Ser Leu Pro Phe Asp Cys Thr Gln Ala Leu Ala Val Pro 
            260                 265                 270         


Lys Pro Ile Gly Gly Val Val Val Phe Ala Val Asn Ser Leu Leu Tyr 
        275                 280                 285             


Leu Asn Gln Ser Val Pro Pro Tyr Gly Val Ala Leu Asn Ser Leu Thr 
    290                 295                 300                 


Thr Gly Thr Thr Ala Phe Pro Leu Arg Thr Gln Glu Gly Val Arg Ile 
305                 310                 315                 320 


Thr Leu Asp Cys Ala Gln Ala Thr Phe Ile Ser Tyr Asp Lys Met Val 
                325                 330                 335     


Ile Ser Leu Lys Gly Gly Glu Ile Tyr Val Leu Thr Leu Ile Thr Asp 
            340                 345                 350         


Gly Met Arg Ser Val Arg Ala Phe His Phe Asp Lys Ala Ala Ala Ser 
        355                 360                 365             


Val Leu Thr Thr Ser Met Val Thr Met Glu Pro Gly Tyr Leu Phe Leu 
    370                 375                 380                 


Gly Ser Arg Leu Gly Asn Ser Leu Leu Leu Lys Tyr Thr Glu Lys Leu 
385                 390                 395                 400 


Gln Glu Pro Pro Ala Ser Ala Val Arg Glu Ala Ala Asp Lys Glu Glu 
                405                 410                 415     


Pro Pro Ser Lys Lys Lys Arg Val Asp Ala Thr Ala Gly Trp Ser Ala 
            420                 425                 430         


Ala Gly Lys Ser Val Pro Gln Asp Glu Val Asp Glu Ile Glu Val Tyr 
        435                 440                 445             


Gly Ser Glu Ala Gln Ser Gly Thr Gln Leu Ala Thr Tyr Ser Phe Glu 
    450                 455                 460                 


Val Cys Asp Ser Ile Leu Asn Ile Gly Pro Cys Ala Asn Ala Ala Val 
465                 470                 475                 480 


Gly Glu Pro Ala Phe Leu Ser Glu Glu Phe Gln Asn Ser Pro Glu Pro 
                485                 490                 495     


Asp Leu Glu Ile Val Val Cys Ser Gly His Gly Lys Asn Gly Ala Leu 
            500                 505                 510         


Ser Val Leu Gln Lys Ser Ile Arg Pro Gln Val Val Thr Thr Phe Glu 
        515                 520                 525             


Leu Pro Gly Cys Tyr Asp Met Trp Thr Val Ile Ala Pro Val Arg Lys 
    530                 535                 540                 


Glu Glu Glu Asp Asn Pro Lys Gly Glu Gly Thr Glu Gln Glu Pro Ser 
545                 550                 555                 560 


Thr Thr Pro Glu Ala Asp Asp Asp Gly Arg Arg His Gly Phe Leu Ile 
                565                 570                 575     


Leu Ser Arg Glu Asp Ser Thr Met Ile Leu Gln Thr Gly Gln Glu Ile 
            580                 585                 590         


Met Glu Leu Asp Thr Ser Gly Phe Ala Thr Gln Gly Pro Thr Val Phe 
        595                 600                 605             


Ala Gly Asn Ile Gly Asp Asn Arg Tyr Ile Val Gln Val Ser Pro Leu 
    610                 615                 620                 


Gly Ile Arg Leu Leu Glu Gly Val Asn Gln Leu His Phe Ile Pro Val 
625                 630                 635                 640 


Asp Leu Gly Ala Pro Ile Val Gln Cys Ala Val Ala Asp Pro Tyr Val 
                645                 650                 655     


Val Ile Met Ser Ala Glu Gly His Val Thr Met Phe Leu Leu Lys Ser 
            660                 665                 670         


Asp Ser Tyr Gly Gly Arg His His Arg Leu Ala Leu His Lys Pro Pro 
        675                 680                 685             


Leu His His Gln Ser Lys Val Ile Thr Leu Cys Leu Tyr Arg Asp Leu 
    690                 695                 700                 


Ser Gly Met Phe Thr Thr Glu Ser Arg Leu Gly Gly Ala Arg Asp Glu 
705                 710                 715                 720 


Leu Gly Gly Arg Ser Gly Pro Glu Ala Glu Gly Leu Gly Ser Glu Thr 
                725                 730                 735     


Ser Pro Thr Val Asp Asp Glu Glu Glu Met Leu Tyr Gly Asp Ser Gly 
            740                 745                 750         


Ser Leu Phe Ser Pro Ser Lys Glu Glu Ala Arg Arg Ser Ser Gln Pro 
        755                 760                 765             


Pro Ala Asp Arg Asp Pro Ala Pro Phe Arg Ala Glu Pro Thr His Trp 
    770                 775                 780                 


Cys Leu Leu Val Arg Glu Asn Gly Thr Met Glu Ile Tyr Gln Leu Pro 
785                 790                 795                 800 


Asp Trp Arg Leu Val Phe Leu Val Lys Asn Phe Pro Val Gly Gln Arg 
                805                 810                 815     


Val Leu Val Asp Ser Ser Phe Gly Gln Pro Thr Thr Gln Gly Glu Ala 
            820                 825                 830         


Arg Arg Glu Glu Ala Thr Arg Gln Gly Glu Leu Pro Leu Val Lys Glu 
        835                 840                 845             


Val Leu Leu Val Ala Leu Gly Ser Arg Gln Ser Arg Pro Tyr Leu Leu 
    850                 855                 860                 


Val His Val Asp Gln Glu Leu Leu Ile Tyr Glu Ala Phe Pro His Asp 
865                 870                 875                 880 


Ser Gln Leu Gly Gln Gly Asn Leu Lys Val Arg Phe Lys Lys Val Pro 
                885                 890                 895     


His Asn Ile Asn Phe Arg Glu Lys Lys Pro Lys Pro Ser Lys Lys Lys 
            900                 905                 910         


Ala Glu Gly Gly Gly Ala Glu Glu Gly Ala Gly Ala Arg Gly Arg Val 
        915                 920                 925             


Ala Arg Phe Arg Tyr Phe Glu Asp Ile Tyr Gly Tyr Ser Gly Val Phe 
    930                 935                 940                 


Ile Cys Gly Pro Ser Pro His Trp Leu Leu Val Thr Gly Arg Gly Ala 
945                 950                 955                 960 


Leu Arg Leu His Pro Met Ala Ile Asp Gly Pro Val Asp Ser Phe Ala 
                965                 970                 975     


Pro Phe His Asn Val Asn Cys Pro Arg Gly Phe Leu Tyr Phe Asn Arg 
            980                 985                 990         


Gln Gly Glu Leu Arg Ile Ser Val  Leu Pro Ala Tyr Leu  Ser Tyr Asp 
        995                 1000                 1005             


Ala Pro  Trp Pro Val Arg Lys  Ile Pro Leu Arg Cys  Thr Ala His 
    1010                 1015                 1020             


Tyr Val  Ala Tyr His Val Glu  Ser Lys Val Tyr Ala  Val Ala Thr 
    1025                 1030                 1035             


Ser Thr  Asn Thr Pro Cys Ala  Arg Ile Pro Arg Met  Thr Gly Glu 
    1040                 1045                 1050             


Glu Lys  Glu Phe Glu Thr Ile  Glu Arg Asp Glu Arg  Tyr Ile His 
    1055                 1060                 1065             


Pro Gln  Gln Glu Ala Phe Ser  Ile Gln Leu Ile Ser  Pro Val Ser 
    1070                 1075                 1080             


Trp Glu  Ala Ile Pro Asn Ala  Arg Ile Glu Leu Gln  Glu Trp Glu 
    1085                 1090                 1095             


His Val  Thr Cys Met Lys Thr  Val Ser Leu Arg Ser  Glu Glu Thr 
    1100                 1105                 1110             


Val Ser  Gly Leu Lys Gly Tyr  Val Ala Ala Gly Thr  Cys Leu Met 
    1115                 1120                 1125             


Gln Gly  Glu Glu Val Thr Cys  Arg Gly Arg Ile Leu  Ile Met Asp 
    1130                 1135                 1140             


Val Ile  Glu Val Val Pro Glu  Pro Gly Gln Pro Leu  Thr Lys Asn 
    1145                 1150                 1155             


Lys Phe  Lys Val Leu Tyr Glu  Lys Glu Gln Lys Gly  Pro Val Thr 
    1160                 1165                 1170             


Ala Leu  Cys His Cys Asn Gly  His Leu Val Ser Ala  Ile Gly Gln 
    1175                 1180                 1185             


Lys Ile  Phe Leu Trp Ser Leu  Arg Ala Ser Glu Leu  Thr Gly Met 
    1190                 1195                 1200             


Ala Phe  Ile Asp Thr Gln Leu  Tyr Ile His Gln Met  Ile Ser Val 
    1205                 1210                 1215             


Lys Asn  Phe Ile Leu Ala Ala  Asp Val Met Lys Ser  Ile Ser Leu 
    1220                 1225                 1230             


Leu Arg  Tyr Gln Glu Glu Ser  Lys Thr Leu Ser Leu  Val Ser Arg 
    1235                 1240                 1245             


Asp Ala  Lys Pro Leu Glu Val  Tyr Ser Val Asp Phe  Met Val Asp 
    1250                 1255                 1260             


Asn Ala  Gln Leu Gly Phe Leu  Val Ser Asp Arg Asp  Arg Asn Leu 
    1265                 1270                 1275             


Met Val  Tyr Met Tyr Leu Pro  Glu Ala Lys Glu Ser  Phe Gly Gly 
    1280                 1285                 1290             


Met Arg  Leu Leu Arg Arg Ala  Asp Phe His Val Gly  Ala His Val 
    1295                 1300                 1305             


Asn Thr  Phe Trp Arg Thr Pro  Cys Arg Gly Ala Thr  Glu Gly Leu 
    1310                 1315                 1320             


Ser Lys  Lys Ser Val Val Trp  Glu Asn Lys His Ile  Thr Trp Phe 
    1325                 1330                 1335             


Ala Thr  Leu Asp Gly Gly Ile  Gly Leu Leu Leu Pro  Met Gln Glu 
    1340                 1345                 1350             


Lys Thr  Tyr Arg Arg Leu Leu  Met Leu Gln Asn Ala  Leu Thr Thr 
    1355                 1360                 1365             


Met Leu  Pro His His Ala Gly  Leu Asn Pro Arg Ala  Phe Arg Met 
    1370                 1375                 1380             


Leu His  Val Asp Arg Arg Thr  Leu Gln Asn Ala Val  Arg Asn Val 
    1385                 1390                 1395             


Leu Asp  Gly Glu Leu Leu Asn  Arg Tyr Leu Tyr Leu  Ser Thr Met 
    1400                 1405                 1410             


Glu Arg  Ser Glu Leu Ala Lys  Lys Ile Gly Thr Thr  Pro Asp Ile 
    1415                 1420                 1425             


Ile Leu  Asp Asp Leu Leu Glu  Thr Asp Arg Val Thr  Ala His Phe 
    1430                 1435                 1440             


<210>  2538
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPSF2__Homo_sapiens__NP_059133

<400>  2538

Met Thr Ser Ile Ile Lys Leu Thr Thr Leu Ser Gly Val Gln Glu Glu 
1               5                   10                  15      


Ser Ala Leu Cys Tyr Leu Leu Gln Val Asp Glu Phe Arg Phe Leu Leu 
            20                  25                  30          


Asp Cys Gly Trp Asp Glu His Phe Ser Met Asp Ile Ile Asp Ser Leu 
        35                  40                  45              


Arg Lys His Val His Gln Ile Asp Ala Val Leu Leu Ser His Pro Asp 
    50                  55                  60                  


Pro Leu His Leu Gly Ala Leu Pro Tyr Ala Val Gly Lys Leu Gly Leu 
65                  70                  75                  80  


Asn Cys Ala Ile Tyr Ala Thr Ile Pro Val Tyr Lys Met Gly Gln Met 
                85                  90                  95      


Phe Met Tyr Asp Leu Tyr Gln Ser Arg His Asn Thr Glu Asp Phe Thr 
            100                 105                 110         


Leu Phe Thr Leu Asp Asp Val Asp Ala Ala Phe Asp Lys Ile Gln Gln 
        115                 120                 125             


Leu Lys Phe Ser Gln Ile Val Asn Leu Lys Gly Lys Gly His Gly Leu 
    130                 135                 140                 


Ser Ile Thr Pro Leu Pro Ala Gly His Met Ile Gly Gly Thr Ile Trp 
145                 150                 155                 160 


Lys Ile Val Lys Asp Gly Glu Glu Glu Ile Val Tyr Ala Val Asp Phe 
                165                 170                 175     


Asn His Lys Arg Glu Ile His Leu Asn Gly Cys Ser Leu Glu Met Leu 
            180                 185                 190         


Ser Arg Pro Ser Leu Leu Ile Thr Asp Ser Phe Asn Ala Thr Tyr Val 
        195                 200                 205             


Gln Pro Arg Arg Lys Gln Arg Asp Glu Gln Leu Leu Thr Asn Val Leu 
    210                 215                 220                 


Glu Thr Leu Arg Gly Asp Gly Asn Val Leu Ile Ala Val Asp Thr Ala 
225                 230                 235                 240 


Gly Arg Val Leu Glu Leu Ala Gln Leu Leu Asp Gln Ile Trp Arg Thr 
                245                 250                 255     


Lys Asp Ala Gly Leu Gly Val Tyr Ser Leu Ala Leu Leu Asn Asn Val 
            260                 265                 270         


Ser Tyr Asn Val Val Glu Phe Ser Lys Ser Gln Val Glu Trp Met Ser 
        275                 280                 285             


Asp Lys Leu Met Arg Cys Phe Glu Asp Lys Arg Asn Asn Pro Phe Gln 
    290                 295                 300                 


Phe Arg His Leu Ser Leu Cys His Gly Leu Ser Asp Leu Ala Arg Val 
305                 310                 315                 320 


Pro Ser Pro Lys Val Val Leu Ala Ser Gln Pro Asp Leu Glu Cys Gly 
                325                 330                 335     


Phe Ser Arg Asp Leu Phe Ile Gln Trp Cys Gln Asp Pro Lys Asn Ser 
            340                 345                 350         


Ile Ile Leu Thr Tyr Arg Thr Thr Pro Gly Thr Leu Ala Arg Phe Leu 
        355                 360                 365             


Ile Asp Asn Pro Ser Glu Lys Ile Thr Glu Ile Glu Leu Arg Lys Arg 
    370                 375                 380                 


Val Lys Leu Glu Gly Lys Glu Leu Glu Glu Tyr Leu Glu Lys Glu Lys 
385                 390                 395                 400 


Leu Lys Lys Glu Ala Ala Lys Lys Leu Glu Gln Ser Lys Glu Ala Asp 
                405                 410                 415     


Ile Asp Ser Ser Asp Glu Ser Asp Ile Glu Glu Asp Ile Asp Gln Pro 
            420                 425                 430         


Ser Ala His Lys Thr Lys His Asp Leu Met Met Lys Gly Glu Gly Ser 
        435                 440                 445             


Arg Lys Gly Ser Phe Phe Lys Gln Ala Lys Lys Ser Tyr Pro Met Phe 
    450                 455                 460                 


Pro Ala Pro Glu Glu Arg Ile Lys Trp Asp Glu Tyr Gly Glu Ile Ile 
465                 470                 475                 480 


Lys Pro Glu Asp Phe Leu Val Pro Glu Leu Gln Ala Thr Glu Glu Glu 
                485                 490                 495     


Lys Ser Lys Leu Glu Ser Gly Leu Thr Asn Gly Asp Glu Pro Met Asp 
            500                 505                 510         


Gln Asp Leu Ser Asp Val Pro Thr Lys Cys Ile Ser Thr Thr Glu Ser 
        515                 520                 525             


Ile Glu Ile Lys Ala Arg Val Thr Tyr Ile Asp Tyr Glu Gly Arg Ser 
    530                 535                 540                 


Asp Gly Asp Ser Ile Lys Lys Ile Ile Asn Gln Met Lys Pro Arg Gln 
545                 550                 555                 560 


Leu Ile Ile Val His Gly Pro Pro Glu Ala Ser Gln Asp Leu Ala Glu 
                565                 570                 575     


Cys Cys Arg Ala Phe Gly Gly Lys Asp Ile Lys Val Tyr Met Pro Lys 
            580                 585                 590         


Leu His Glu Thr Val Asp Ala Thr Ser Glu Thr His Ile Tyr Gln Val 
        595                 600                 605             


Arg Leu Lys Asp Ser Leu Val Ser Ser Leu Gln Phe Cys Lys Ala Lys 
    610                 615                 620                 


Asp Ala Glu Leu Ala Trp Ile Asp Gly Val Leu Asp Met Arg Val Ser 
625                 630                 635                 640 


Lys Val Asp Thr Gly Val Ile Leu Glu Glu Gly Glu Leu Lys Asp Asp 
                645                 650                 655     


Gly Glu Asp Ser Glu Met Gln Val Glu Ala Pro Ser Asp Ser Ser Val 
            660                 665                 670         


Ile Ala Gln Gln Lys Ala Met Lys Ser Leu Phe Gly Asp Asp Glu Lys 
        675                 680                 685             


Glu Thr Gly Glu Glu Ser Glu Ile Ile Pro Thr Leu Glu Pro Leu Pro 
    690                 695                 700                 


Pro His Glu Val Pro Gly His Gln Ser Val Phe Met Asn Glu Pro Arg 
705                 710                 715                 720 


Leu Ser Asp Phe Lys Gln Val Leu Leu Arg Glu Gly Ile Gln Ala Glu 
                725                 730                 735     


Phe Val Gly Gly Val Leu Val Cys Asn Asn Gln Val Ala Val Arg Arg 
            740                 745                 750         


Thr Glu Thr Gly Arg Ile Gly Leu Glu Gly Cys Leu Cys Gln Asp Phe 
        755                 760                 765             


Tyr Arg Ile Arg Asp Leu Leu Tyr Glu Gln Tyr Ala Ile Val 
    770                 775                 780         


<210>  2539
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPSF3__Homo_sapiens__NP_057291

<400>  2539

Met Ser Ala Ile Pro Ala Glu Glu Ser Asp Gln Leu Leu Ile Arg Pro 
1               5                   10                  15      


Leu Gly Ala Gly Gln Glu Val Gly Arg Ser Cys Ile Ile Leu Glu Phe 
            20                  25                  30          


Lys Gly Arg Lys Ile Met Leu Asp Cys Gly Ile His Pro Gly Leu Glu 
        35                  40                  45              


Gly Met Asp Ala Leu Pro Tyr Ile Asp Leu Ile Asp Pro Ala Glu Ile 
    50                  55                  60                  


Asp Leu Leu Leu Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu 
65                  70                  75                  80  


Pro Trp Phe Leu Gln Lys Thr Ser Phe Lys Gly Arg Thr Phe Met Thr 
                85                  90                  95      


His Ala Thr Lys Ala Ile Tyr Arg Trp Leu Leu Ser Asp Tyr Val Lys 
            100                 105                 110         


Val Ser Asn Ile Ser Ala Asp Asp Met Leu Tyr Thr Glu Thr Asp Leu 
        115                 120                 125             


Glu Glu Ser Met Asp Lys Ile Glu Thr Ile Asn Phe His Glu Val Lys 
    130                 135                 140                 


Glu Val Ala Gly Ile Lys Phe Trp Cys Tyr His Ala Gly His Val Leu 
145                 150                 155                 160 


Gly Ala Ala Met Phe Met Ile Glu Ile Ala Gly Val Lys Leu Leu Tyr 
                165                 170                 175     


Thr Gly Asp Phe Ser Arg Gln Glu Asp Arg His Leu Met Ala Ala Glu 
            180                 185                 190         


Ile Pro Asn Ile Lys Pro Asp Ile Leu Ile Ile Glu Ser Thr Tyr Gly 
        195                 200                 205             


Thr His Ile His Glu Lys Arg Glu Glu Arg Glu Ala Arg Phe Cys Asn 
    210                 215                 220                 


Thr Val His Asp Ile Val Asn Arg Gly Gly Arg Gly Leu Ile Pro Val 
225                 230                 235                 240 


Phe Ala Leu Gly Arg Ala Gln Glu Leu Leu Leu Ile Leu Asp Glu Tyr 
                245                 250                 255     


Trp Gln Asn His Pro Glu Leu His Asp Ile Pro Ile Tyr Tyr Ala Ser 
            260                 265                 270         


Ser Leu Ala Lys Lys Cys Met Ala Val Tyr Gln Thr Tyr Val Asn Ala 
        275                 280                 285             


Met Asn Asp Lys Ile Arg Lys Gln Ile Asn Ile Asn Asn Pro Phe Val 
    290                 295                 300                 


Phe Lys His Ile Ser Asn Leu Lys Ser Met Asp His Phe Asp Asp Ile 
305                 310                 315                 320 


Gly Pro Ser Val Val Met Ala Ser Pro Gly Met Met Gln Ser Gly Leu 
                325                 330                 335     


Ser Arg Glu Leu Phe Glu Ser Trp Cys Thr Asp Lys Arg Asn Gly Val 
            340                 345                 350         


Ile Ile Ala Gly Tyr Cys Val Glu Gly Thr Leu Ala Lys His Ile Met 
        355                 360                 365             


Ser Glu Pro Glu Glu Ile Thr Thr Met Ser Gly Gln Lys Leu Pro Leu 
    370                 375                 380                 


Lys Met Ser Val Asp Tyr Ile Ser Phe Ser Ala His Thr Asp Tyr Gln 
385                 390                 395                 400 


Gln Thr Ser Glu Phe Ile Arg Ala Leu Lys Pro Pro His Val Ile Leu 
                405                 410                 415     


Val His Gly Glu Gln Asn Glu Met Ala Arg Leu Lys Ala Ala Leu Ile 
            420                 425                 430         


Arg Glu Tyr Glu Asp Asn Asp Glu Val His Ile Glu Val His Asn Pro 
        435                 440                 445             


Arg Asn Thr Glu Ala Val Thr Leu Asn Phe Arg Gly Glu Lys Leu Ala 
    450                 455                 460                 


Lys Val Met Gly Phe Leu Ala Asp Lys Lys Pro Glu Gln Gly Gln Arg 
465                 470                 475                 480 


Val Ser Gly Ile Leu Val Lys Arg Asn Phe Asn Tyr His Ile Leu Ser 
                485                 490                 495     


Pro Cys Asp Leu Ser Asn Tyr Thr Asp Leu Ala Met Ser Thr Val Lys 
            500                 505                 510         


Gln Thr Gln Ala Ile Pro Tyr Thr Gly Pro Phe Asn Leu Leu Cys Tyr 
        515                 520                 525             


Gln Leu Gln Lys Leu Thr Gly Asp Val Glu Glu Leu Glu Ile Gln Glu 
    530                 535                 540                 


Lys Pro Ala Leu Lys Val Phe Lys Asn Ile Thr Val Ile Gln Glu Pro 
545                 550                 555                 560 


Gly Met Val Val Leu Glu Trp Leu Ala Asn Pro Ser Asn Asp Met Tyr 
                565                 570                 575     


Ala Asp Thr Val Thr Thr Val Ile Leu Glu Val Gln Ser Asn Pro Lys 
            580                 585                 590         


Ile Arg Lys Gly Ala Val Gln Lys Val Ser Lys Lys Leu Glu Met His 
        595                 600                 605             


Val Tyr Ser Lys Arg Leu Glu Ile Met Leu Gln Asp Ile Phe Gly Glu 
    610                 615                 620                 


Asp Cys Val Ser Val Lys Asp Asp Ser Ile Leu Ser Val Thr Val Asp 
625                 630                 635                 640 


Gly Lys Thr Ala Asn Leu Asn Leu Glu Thr Arg Thr Val Glu Cys Glu 
                645                 650                 655     


Glu Gly Ser Glu Asp Asp Glu Ser Leu Arg Glu Met Val Glu Leu Ala 
            660                 665                 670         


Ala Gln Arg Leu Tyr Glu Ala Leu Thr Pro Val His 
        675                 680                 


<210>  2540
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPSF3L__Homo_sapiens__XP_011539949

<400>  2540

Met Pro Glu Ile Arg Val Thr Pro Leu Gly Ala Cys Pro Val Leu Ser 
1               5                   10                  15      


Trp Asn Leu Val Leu Pro Pro Gly Arg Gly Ser Arg Ala Pro Ser Ser 
            20                  25                  30          


Thr Asp Thr Arg Thr Gly Phe His Val Leu Pro His Gly Pro Leu Gly 
        35                  40                  45              


Cys Gly Pro Val Ile Leu Met Cys Gly Ala Gly Phe Gly His Phe Glu 
    50                  55                  60                  


Trp Leu Ala Gly Gly Gly Ala Gly Gln Asp Val Gly Arg Ser Cys Ile 
65                  70                  75                  80  


Leu Val Ser Ile Ala Gly Lys Asn Val Met Leu Asp Cys Gly Met His 
                85                  90                  95      


Met Gly Phe Asn Asp Asp Arg Arg Phe Pro Asp Phe Ser Tyr Ile Thr 
            100                 105                 110         


Gln Asn Gly Arg Leu Thr Asp Phe Leu Asp Cys Val Ile Ile Ser His 
        115                 120                 125             


Phe His Leu Asp His Cys Gly Ala Leu Pro Tyr Phe Ser Glu Met Val 
    130                 135                 140                 


Gly Tyr Asp Gly Pro Ile Tyr Met Thr His Pro Thr Gln Ala Ile Cys 
145                 150                 155                 160 


Pro Ile Leu Leu Glu Asp Tyr Arg Lys Ile Ala Val Asp Lys Lys Gly 
                165                 170                 175     


Glu Ala Asn Phe Phe Thr Ser Gln Met Ile Lys Asp Cys Met Lys Lys 
            180                 185                 190         


Val Val Ala Val His Leu His Gln Thr Val Gln Val Asp Asp Glu Leu 
        195                 200                 205             


Glu Ile Lys Ala Tyr Tyr Ala Gly His Val Leu Gly Ala Ala Met Phe 
    210                 215                 220                 


Gln Ile Lys Val Gly Ser Glu Ser Val Val Tyr Thr Gly Asp Tyr Asn 
225                 230                 235                 240 


Met Thr Pro Asp Arg His Leu Gly Ala Ala Trp Ile Asp Lys Cys Arg 
                245                 250                 255     


Pro Asn Leu Leu Ile Thr Glu Ser Thr Tyr Ala Thr Thr Ile Arg Asp 
            260                 265                 270         


Ser Lys Arg Cys Arg Glu Arg Asp Phe Leu Lys Lys Val His Glu Thr 
        275                 280                 285             


Val Glu Arg Gly Gly Lys Val Leu Ile Pro Val Phe Ala Leu Gly Arg 
    290                 295                 300                 


Ala Gln Glu Leu Cys Ile Leu Leu Glu Thr Phe Trp Glu Arg Met Asn 
305                 310                 315                 320 


Leu Lys Val Pro Ile Tyr Phe Ser Thr Gly Leu Thr Glu Lys Ala Asn 
                325                 330                 335     


His Tyr Tyr Lys Leu Phe Ile Pro Trp Thr Asn Gln Lys Ile Arg Lys 
            340                 345                 350         


Thr Phe Val Gln Arg Asn Met Phe Glu Phe Lys His Ile Lys Ala Phe 
        355                 360                 365             


Asp Arg Ala Phe Ala Asp Asn Pro Gly Pro Met Val Val Phe Ala Thr 
    370                 375                 380                 


Pro Gly Met Leu His Ala Gly Gln Ser Leu Gln Ile Phe Arg Lys Trp 
385                 390                 395                 400 


Ala Gly Asn Glu Lys Asn Met Val Ile Met Pro Gly Tyr Cys Val Gln 
                405                 410                 415     


Gly Thr Val Gly His Lys Ile Leu Ser Gly Gln Arg Lys Leu Glu Met 
            420                 425                 430         


Glu Gly Arg Gln Val Leu Glu Val Lys Met Gln Val Glu Tyr Met Ser 
        435                 440                 445             


Phe Ser Ala His Ala Asp Ala Lys Gly Ile Met Gln Leu Val Gly Gln 
    450                 455                 460                 


Ala Glu Pro Glu Ser Val Leu Leu Val His Gly Glu Ala Lys Lys Met 
465                 470                 475                 480 


Glu Phe Leu Lys Gln Lys Ile Glu Gln Glu Leu Arg Val Asn Cys Tyr 
                485                 490                 495     


Met Pro Ala Asn Gly Glu Thr Val Thr Leu Pro Thr Ser Pro Ser Ile 
            500                 505                 510         


Pro Val Gly Ile Ser Leu Gly Leu Leu Lys Arg Glu Met Ala Gln Gly 
        515                 520                 525             


Leu Leu Pro Glu Ala Lys Lys Pro Arg Leu Leu His Gly Thr Leu Ile 
    530                 535                 540                 


Met Lys Asp Ser Asn Phe Arg Leu Val Ser Ser Glu Gln Ala Leu Lys 
545                 550                 555                 560 


Glu Leu Gly Leu Ala Glu His Gln Leu Arg Phe Thr Cys Arg Val His 
                565                 570                 575     


Leu His Asp Thr Arg Lys Glu Gln Glu Thr Ala Leu Arg Val Tyr Ser 
            580                 585                 590         


His Leu Lys Ser Val Leu Lys Asp His Cys Val Gln His Leu Pro Asp 
        595                 600                 605             


Gly Ser Val Thr Val Glu Ser Val Leu Leu Gln Ala Ala Ala Pro Ser 
    610                 615                 620                 


Glu Asp Pro Gly Thr Lys Val Leu Leu Val Ser Trp Thr Tyr Gln Asp 
625                 630                 635                 640 


Glu Glu Leu Gly Ser Phe Leu Thr Ser Leu Leu Lys Lys Gly Leu Pro 
                645                 650                 655     


Gln Ala Pro Ser 
            660 


<210>  2541
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPSF4__Homo_sapiens__NP_001075028

<400>  2541

Met Gln Glu Ile Ile Ala Ser Val Asp His Ile Lys Phe Asp Leu Glu 
1               5                   10                  15      


Ile Ala Val Glu Gln Gln Leu Gly Ala Gln Pro Leu Pro Phe Pro Gly 
            20                  25                  30          


Met Asp Lys Ser Gly Ala Ala Val Cys Glu Phe Phe Leu Lys Ala Ala 
        35                  40                  45              


Cys Gly Lys Gly Gly Met Cys Pro Phe Arg His Ile Ser Gly Glu Lys 
    50                  55                  60                  


Thr Val Val Cys Lys His Trp Leu Arg Gly Leu Cys Lys Lys Gly Asp 
65                  70                  75                  80  


Gln Cys Glu Phe Leu His Glu Tyr Asp Met Thr Lys Met Pro Glu Cys 
                85                  90                  95      


Tyr Phe Tyr Ser Lys Phe Gly Glu Cys Ser Asn Lys Glu Cys Pro Phe 
            100                 105                 110         


Leu His Ile Asp Pro Glu Ser Lys Ile Lys Asp Cys Pro Trp Tyr Asp 
        115                 120                 125             


Arg Gly Phe Cys Lys His Gly Pro Leu Cys Arg His Arg His Thr Arg 
    130                 135                 140                 


Arg Val Ile Cys Val Asn Tyr Leu Val Gly Phe Cys Pro Glu Gly Pro 
145                 150                 155                 160 


Ser Cys Lys Phe Met His Pro Arg Phe Glu Leu Pro Met Gly Thr Thr 
                165                 170                 175     


Glu Gln Pro Pro Leu Pro Gln Gln Thr Gln Pro Pro Ala Lys Gln Arg 
            180                 185                 190         


Thr Pro Gln Val Ile Gly Val Met Gln Ser Gln Asn Ser Ser Ala Gly 
        195                 200                 205             


Asn Arg Gly Pro Arg Pro Leu Glu Gln Val Thr Cys Tyr Lys Cys Gly 
    210                 215                 220                 


Glu Lys Gly His Tyr Ala Asn Arg Cys Thr Lys Gly His Leu Ala Phe 
225                 230                 235                 240 


Leu Ser Gly Gln 
                


<210>  2542
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPSF6__Homo_sapiens__NP_001287876

<400>  2542

Met Ala Asp Gly Val Asp His Ile Asp Ile Tyr Ala Asp Val Gly Glu 
1               5                   10                  15      


Glu Phe Asn Gln Glu Ala Glu Tyr Gly Gly His Asp Gln Ile Asp Leu 
            20                  25                  30          


Tyr Asp Asp Val Ile Ser Pro Ser Ala Asn Asn Gly Asp Ala Pro Glu 
        35                  40                  45              


Asp Arg Asp Tyr Met Asp Thr Leu Pro Pro Thr Val Gly Asp Asp Val 
    50                  55                  60                  


Gly Lys Gly Ala Ala Pro Asn Val Val Tyr Thr Tyr Thr Gly Lys Arg 
65                  70                  75                  80  


Ile Ala Leu Tyr Ile Gly Asn Leu Thr Trp Trp Thr Thr Asp Glu Asp 
                85                  90                  95      


Leu Thr Glu Ala Val His Ser Leu Gly Val Asn Asp Ile Leu Glu Ile 
            100                 105                 110         


Lys Phe Phe Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Phe Ala Leu 
        115                 120                 125             


Val Gly Val Gly Ser Glu Ala Ser Ser Lys Lys Leu Met Asp Leu Leu 
    130                 135                 140                 


Pro Lys Arg Glu Leu His Gly Gln Asn Pro Val Val Thr Pro Cys Asn 
145                 150                 155                 160 


Lys Gln Phe Leu Ser Gln Phe Glu Met Gln Ser Arg Lys Thr Thr Gln 
                165                 170                 175     


Ser Gly Gln Met Ser Gly Glu Gly Lys Ala Gly Pro Pro Gly Gly Ser 
            180                 185                 190         


Ser Arg Ala Ala Phe Pro Gln Gly Gly Arg Gly Arg Gly Arg Phe Pro 
        195                 200                 205             


Gly Ala Val Pro Gly Gly Asp Arg Phe Pro Gly Pro Ala Gly Pro Gly 
    210                 215                 220                 


Gly Pro Pro Pro Pro Phe Pro Gly Asn Leu Ile Lys His Leu Val Lys 
225                 230                 235                 240 


Gly Thr Arg Pro Leu Phe Leu Glu Thr Arg Ile Pro Trp His Met Gly 
                245                 250                 255     


His Ser Ile Glu Glu Ile Pro Ile Phe Gly Leu Lys Ala Gly Gln Thr 
            260                 265                 270         


Pro Pro Arg Pro Pro Leu Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
        275                 280                 285             


Pro Pro Pro Pro Gly Gln Val Leu Pro Pro Pro Leu Ala Gly Pro Pro 
    290                 295                 300                 


Asn Arg Gly Asp Arg Pro Pro Pro Pro Val Leu Phe Pro Gly Gln Pro 
305                 310                 315                 320 


Phe Gly Gln Pro Pro Leu Gly Pro Leu Pro Pro Gly Pro Pro Pro Pro 
                325                 330                 335     


Val Pro Gly Tyr Gly Pro Pro Pro Gly Pro Pro Pro Pro Gln Gln Gly 
            340                 345                 350         


Pro Pro Pro Pro Pro Gly Pro Phe Pro Pro Arg Pro Pro Gly Pro Leu 
        355                 360                 365             


Gly Pro Pro Leu Thr Leu Ala Pro Pro Pro His Leu Pro Gly Pro Pro 
    370                 375                 380                 


Pro Gly Ala Pro Pro Pro Ala Pro His Val Asn Pro Ala Phe Phe Pro 
385                 390                 395                 400 


Pro Pro Thr Asn Ser Gly Met Pro Thr Ser Asp Ser Arg Gly Pro Pro 
                405                 410                 415     


Pro Thr Asp Pro Tyr Gly Arg Pro Pro Pro Tyr Asp Arg Gly Asp Tyr 
            420                 425                 430         


Gly Pro Pro Gly Arg Glu Met Asp Thr Ala Arg Thr Pro Leu Ser Glu 
        435                 440                 445             


Ala Glu Phe Glu Glu Ile Met Asn Arg Asn Arg Ala Ile Ser Ser Ser 
    450                 455                 460                 


Ala Ile Ser Arg Ala Val Ser Asp Ala Ser Ala Gly Asp Tyr Gly Ser 
465                 470                 475                 480 


Ala Ile Glu Thr Leu Val Thr Ala Ile Ser Leu Ile Lys Gln Ser Lys 
                485                 490                 495     


Val Ser Ala Asp Asp Arg Cys Lys Val Leu Ile Ser Ser Leu Gln Asp 
            500                 505                 510         


Cys Leu His Gly Ile Glu Ser Lys Ser Tyr Gly Ser Gly Ser Arg Arg 
        515                 520                 525             


Glu Arg Ser Arg Glu Arg Asp His Ser Arg Ser Arg Glu Lys Ser Arg 
    530                 535                 540                 


Arg His Lys Ser Arg Ser Arg Asp Arg His Asp Asp Tyr Tyr Arg Glu 
545                 550                 555                 560 


Arg Ser Arg Glu Arg Glu Arg His Arg Asp Arg Asp Arg Asp Arg Asp 
                565                 570                 575     


Arg Glu Arg Asp Arg Glu Arg Glu Tyr Arg His Arg 
            580                 585             


<210>  2543
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPSF7__Homo_sapiens__NP_001129512

<400>  2543

Met Ser Glu Gly Val Asp Leu Ile Asp Ile Tyr Ala Asp Glu Glu Phe 
1               5                   10                  15      


Asn Gln Asp Pro Glu Phe Asn Asn Thr Asp Gln Ile Asp Leu Tyr Asp 
            20                  25                  30          


Asp Val Leu Thr Ala Thr Ser Gln Pro Ser Asp Asp Arg Ser Ser Ser 
        35                  40                  45              


Thr Glu Pro Pro Pro Pro Val Arg Gln Glu Pro Ser Pro Lys Pro Asn 
    50                  55                  60                  


Asn Lys Thr Pro Ala Ile Leu Tyr Thr Tyr Ser Gly Leu Arg Asn Arg 
65                  70                  75                  80  


Arg Ala Ala Val Tyr Val Gly Ser Phe Ser Trp Trp Thr Thr Asp Gln 
                85                  90                  95      


Gln Leu Ile Gln Val Ile Arg Ser Ile Gly Val Tyr Asp Val Val Glu 
            100                 105                 110         


Leu Lys Phe Ala Glu Asn Arg Ala Asn Gly Gln Ser Lys Gly Tyr Ala 
        115                 120                 125             


Glu Val Val Val Ala Ser Glu Asn Ser Val His Lys Leu Leu Glu Leu 
    130                 135                 140                 


Leu Pro Gly Lys Val Leu Asn Gly Glu Lys Val Asp Val Arg Pro Ala 
145                 150                 155                 160 


Thr Arg Gln Asn Leu Ser Gln Phe Glu Ala Gln Ala Arg Lys Arg Glu 
                165                 170                 175     


Cys Val Arg Val Pro Arg Gly Gly Ile Pro Pro Arg Ala His Ser Arg 
            180                 185                 190         


Asp Ser Ser Asp Ser Ala Asp Gly Arg Ala Thr Pro Ser Glu Asn Leu 
        195                 200                 205             


Val Pro Ser Ser Ala Arg Val Asp Lys Pro Pro Ser Val Leu Pro Tyr 
    210                 215                 220                 


Phe Asn Arg Pro Pro Ser Ala Leu Pro Leu Met Gly Leu Pro Pro Pro 
225                 230                 235                 240 


Pro Ile Pro Pro Pro Pro Pro Leu Ser Ser Ser Phe Gly Val Pro Pro 
                245                 250                 255     


Pro Pro Pro Gly Ile His Tyr Gln His Leu Met Pro Pro Pro Pro Arg 
            260                 265                 270         


Leu Pro Pro His Leu Ala Val Pro Pro Pro Gly Ala Ile Pro Pro Ala 
        275                 280                 285             


Leu His Leu Asn Pro Ala Phe Phe Pro Pro Pro Asn Ala Thr Val Gly 
    290                 295                 300                 


Pro Pro Pro Asp Thr Tyr Met Lys Ala Ser Ala Pro Tyr Asn His His 
305                 310                 315                 320 


Gly Ser Arg Asp Ser Gly Pro Pro Pro Ser Thr Val Ser Glu Ala Glu 
                325                 330                 335     


Phe Glu Asp Ile Met Lys Arg Asn Arg Ala Ile Ser Ser Ser Ala Ile 
            340                 345                 350         


Ser Lys Ala Val Ser Gly Ala Ser Ala Gly Asp Tyr Ser Asp Ala Ile 
        355                 360                 365             


Glu Thr Leu Leu Thr Ala Ile Ala Val Ile Lys Gln Ser Arg Val Ala 
    370                 375                 380                 


Asn Asp Glu Arg Cys Arg Val Leu Ile Ser Ser Leu Lys Asp Cys Leu 
385                 390                 395                 400 


His Gly Ile Glu Ala Lys Ser Tyr Ser Val Gly Ala Ser Gly Ser Ser 
                405                 410                 415     


Ser Arg Lys Arg His Arg Ser Arg Glu Arg Ser Pro Ser Arg Ser Arg 
            420                 425                 430         


Glu Ser Ser Arg Arg His Arg Asp Leu Leu His Asn Glu Asp Arg His 
        435                 440                 445             


Asp Asp Tyr Phe Gln Glu Arg Asn Arg Glu His Glu Arg His Arg Asp 
    450                 455                 460                 


Arg Glu Arg Asp Arg His His 
465                 470     


<210>  2544
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPT1A__Homo_sapiens__XP_005273819

<400>  2544

Met Gln His Leu Ser Ser Glu Ala Leu Ser Thr Glu Leu Ser Pro Gln 
1               5                   10                  15      


Leu Gly Thr Ala Gly Leu Asp Leu Pro Thr Glu Arg Tyr Ser Leu Lys 
            20                  25                  30          


Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
        35                  40                  45              


Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr 
    50                  55                  60                  


Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
65                  70                  75                  80  


Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile 
                85                  90                  95      


Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser 
            100                 105                 110         


Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys 
        115                 120                 125             


Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr 
    130                 135                 140                 


Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val 
145                 150                 155                 160 


Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser 
                165                 170                 175     


Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg 
            180                 185                 190         


Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
        195                 200                 205             


Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro 
    210                 215                 220                 


Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp 
225                 230                 235                 240 


Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys 
                245                 250                 255     


Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
            260                 265                 270         


Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
        275                 280                 285             


Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala 
    290                 295                 300                 


Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg 
305                 310                 315                 320 


Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
                325                 330                 335     


Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu 
            340                 345                 350         


Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val 
        355                 360                 365             


Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
    370                 375                 380                 


Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp 
385                 390                 395                 400 


Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr 
                405                 410                 415     


Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly 
            420                 425                 430         


Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
        435                 440                 445             


Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro 
    450                 455                 460                 


Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
465                 470                 475                 480 


Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn 
                485                 490                 495     


Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Pro Ile 
            500                 505                 510         


Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu 
        515                 520                 525             


Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile 
    530                 535                 540                 


Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
545                 550                 555                 560 


Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val 
                565                 570                 575     


Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys 
            580                 585                 590         


Lys Cys Arg Thr Ser Pro Asp Ala Phe Val Gln Leu Ala Leu Gln Leu 
        595                 600                 605             


Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
    610                 615                 620                 


Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
625                 630                 635                 640 


Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln 
                645                 650                 655     


Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His 
            660                 665                 670         


Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His 
        675                 680                 685             


Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro 
    690                 695                 700                 


Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
705                 710                 715                 720 


Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu 
                725                 730                 735     


Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
            740                 745                 750         


Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile 
        755                 760                 765             


Ser Ser Lys Phe Ser Cys Pro Glu Thr Asp Ser His Arg Phe Gly Arg 
    770                 775                 780                 


His Leu Lys Glu Ala Met Thr Asp Ile Ile Thr Leu Phe Gly Leu Ser 
785                 790                 795                 800 


Ser Asn Ser Lys Lys 
                805 


<210>  2545
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPT1B__Homo_sapiens__NP_001138606

<400>  2545

Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
1               5                   10                  15      


Asp Gly Val Asp Phe Arg Leu Ser Arg Glu Ala Leu Lys His Val Tyr 
            20                  25                  30          


Leu Ser Gly Ile Asn Ser Trp Lys Lys Arg Leu Ile Arg Ile Lys Asn 
        35                  40                  45              


Gly Ile Leu Arg Gly Val Tyr Pro Gly Ser Pro Thr Ser Trp Leu Val 
    50                  55                  60                  


Val Ile Met Ala Thr Val Gly Ser Ser Phe Cys Asn Val Asp Ile Ser 
65                  70                  75                  80  


Leu Gly Leu Val Ser Cys Ile Gln Arg Cys Leu Pro Gln Gly Cys Gly 
                85                  90                  95      


Pro Tyr Gln Thr Pro Gln Thr Arg Ala Leu Leu Ser Met Ala Ile Phe 
            100                 105                 110         


Ser Thr Gly Val Trp Val Thr Gly Ile Phe Phe Phe Arg Gln Thr Leu 
        115                 120                 125             


Lys Leu Leu Leu Cys Tyr His Gly Trp Met Phe Glu Met His Gly Lys 
    130                 135                 140                 


Thr Ser Asn Leu Thr Arg Ile Trp Ala Tyr Leu Glu Ser Val Arg Pro 
145                 150                 155                 160 


Leu Leu Asp Asp Glu Glu Tyr Tyr Arg Met Glu Leu Leu Ala Lys Glu 
                165                 170                 175     


Phe Gln Asp Lys Thr Ala Pro Arg Leu Gln Lys Tyr Leu Val Leu Lys 
            180                 185                 190         


Ser Trp Trp Ala Ser Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
        195                 200                 205             


Tyr Leu Arg Gly Arg Ser Pro Leu Met Val Asn Ser Asn Tyr Tyr Val 
    210                 215                 220                 


Met Asp Leu Val Leu Ile Lys Asn Thr Asp Val Gln Ala Ala Arg Leu 
225                 230                 235                 240 


Gly Asn Ile Ile His Ala Met Ile Met Tyr Arg Arg Lys Leu Asp Arg 
                245                 250                 255     


Glu Glu Ile Lys Pro Val Met Ala Leu Gly Ile Val Pro Met Cys Ser 
            260                 265                 270         


Tyr Gln Met Glu Arg Met Phe Asn Thr Thr Arg Ile Pro Gly Lys Asp 
        275                 280                 285             


Thr Asp Val Leu Gln His Leu Ser Asp Ser Arg His Val Ala Val Tyr 
    290                 295                 300                 


His Lys Gly Arg Phe Phe Lys Leu Trp Leu Tyr Glu Gly Ala Arg Leu 
305                 310                 315                 320 


Leu Lys Pro Gln Asp Leu Glu Met Gln Phe Gln Arg Ile Leu Asp Asp 
                325                 330                 335     


Pro Ser Pro Pro Gln Pro Gly Glu Glu Lys Leu Ala Ala Leu Thr Ala 
            340                 345                 350         


Gly Gly Arg Val Glu Trp Ala Gln Ala Arg Gln Ala Phe Phe Ser Ser 
        355                 360                 365             


Gly Lys Asn Lys Ala Ala Leu Glu Ala Ile Glu Arg Ala Ala Phe Phe 
    370                 375                 380                 


Val Ala Leu Asp Glu Glu Ser Tyr Ser Tyr Asp Pro Glu Asp Glu Ala 
385                 390                 395                 400 


Ser Leu Ser Leu Tyr Gly Lys Ala Leu Leu His Gly Asn Cys Tyr Asn 
                405                 410                 415     


Arg Trp Phe Asp Lys Ser Phe Thr Leu Ile Ser Phe Lys Asn Gly Gln 
            420                 425                 430         


Leu Gly Leu Asn Ala Glu His Ala Trp Ala Asp Ala Pro Ile Ile Gly 
        435                 440                 445             


His Leu Trp Glu Phe Val Leu Gly Thr Asp Ser Phe His Leu Gly Tyr 
    450                 455                 460                 


Thr Glu Thr Gly His Cys Leu Gly Lys Pro Asn Pro Ala Leu Ala Pro 
465                 470                 475                 480 


Pro Thr Arg Leu Gln Trp Asp Ile Pro Lys Gln Cys Gln Ala Val Ile 
                485                 490                 495     


Glu Ser Ser Tyr Gln Val Ala Lys Ala Leu Ala Asp Asp Val Glu Leu 
            500                 505                 510         


Tyr Cys Phe Gln Phe Leu Pro Phe Gly Lys Gly Leu Ile Lys Lys Cys 
        515                 520                 525             


Arg Thr Ser Pro Asp Ala Phe Val Gln Ile Ala Leu Gln Leu Ala His 
    530                 535                 540                 


Phe Arg Asp Arg Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser Met Thr 
545                 550                 555                 560 


Arg Met Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys Thr Ser 
                565                 570                 575     


Glu Ser Thr Ala Phe Val Gln Ala Met Met Glu Gly Ser His Thr Lys 
            580                 585                 590         


Ala Asp Leu Arg Asp Leu Phe Gln Lys Ala Ala Lys Lys His Gln Asn 
        595                 600                 605             


Met Tyr Arg Leu Ala Met Thr Gly Ala Gly Ile Asp Arg His Leu Phe 
    610                 615                 620                 


Cys Leu Tyr Leu Val Ser Lys Tyr Leu Gly Val Ser Ser Pro Phe Leu 
625                 630                 635                 640 


Ala Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln Ile Pro 
                645                 650                 655     


Gln Ser Gln Ile Arg Met Phe Asp Pro Glu Gln His Pro Asn His Leu 
            660                 665                 670         


Gly Ala Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr Gly Val 
        675                 680                 685             


Ser Tyr Met Ile Ala Gly Glu Asn Thr Ile Phe Phe His Ile Ser Ser 
    690                 695                 700                 


Lys Phe Ser Ser Ser Glu Thr Asn Ala Gln Arg Phe Gly Asn His Ile 
705                 710                 715                 720 


Arg Lys Ala Leu Leu Asp Ile Ala Asp Leu Phe Gln Val Pro Lys Ala 
                725                 730                 735     


Tyr Ser 
        


<210>  2546
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPT1C__Homo_sapiens__NP_001129524

<400>  2546

Met Ala Glu Ala His Gln Ala Val Gly Phe Arg Pro Ser Leu Thr Ser 
1               5                   10                  15      


Asp Gly Ala Glu Val Glu Leu Ser Ala Pro Val Leu Gln Glu Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu Arg Ser Trp Lys Arg His Leu Ser Arg Phe Trp Asn 
        35                  40                  45              


Asp Phe Leu Thr Gly Val Phe Pro Ala Ser Pro Leu Ser Trp Leu Phe 
    50                  55                  60                  


Leu Phe Ser Ala Ile Gln Leu Ala Trp Phe Leu Gln Leu Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Leu Met Glu Lys Ile Lys Glu Leu Leu Pro Asp Trp Gly Gly 
                85                  90                  95      


Gln His His Gly Leu Arg Gly Val Leu Ala Ala Ala Leu Phe Ala Ser 
            100                 105                 110         


Cys Leu Trp Gly Ala Leu Ile Phe Thr Leu His Val Ala Leu Arg Leu 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Leu Leu Glu Pro His Gly Ala Met Ser 
    130                 135                 140                 


Ser Pro Thr Lys Thr Trp Leu Ala Leu Val Arg Ile Phe Ser Gly Arg 
145                 150                 155                 160 


His Pro Met Leu Phe Ser Tyr Gln Arg Ser Leu Pro Arg Gln Pro Val 
                165                 170                 175     


Pro Ser Val Gln Asp Thr Val Arg Lys Tyr Leu Glu Ser Val Arg Pro 
            180                 185                 190         


Ile Leu Ser Asp Glu Asp Phe Asp Trp Thr Ala Val Leu Ala Gln Glu 
        195                 200                 205             


Phe Leu Arg Leu Gln Ala Ser Leu Leu Gln Trp Tyr Leu Arg Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Ser Asn Tyr Val Ser Asp Trp Trp Glu Glu Phe Val 
225                 230                 235                 240 


Tyr Leu Arg Ser Arg Asn Pro Leu Met Val Asn Ser Asn Tyr Tyr Met 
                245                 250                 255     


Met Ala Ala Arg Ala Gly Asn Ala Val His Ala Leu Leu Leu Tyr Arg 
            260                 265                 270         


His Arg Leu Asn Arg Gln Glu Ile Pro Pro Thr Leu Leu Met Gly Met 
        275                 280                 285             


Arg Pro Leu Cys Ser Ala Gln Tyr Glu Lys Ile Phe Asn Thr Thr Arg 
    290                 295                 300                 


Ile Pro Gly Val Gln Lys Asp Tyr Ile Arg His Leu His Asp Ser Gln 
305                 310                 315                 320 


His Val Ala Val Phe His Arg Gly Arg Phe Phe Arg Met Gly Thr His 
                325                 330                 335     


Ser Arg Asn Ser Leu Leu Ser Pro Arg Ala Leu Glu Gln Gln Phe Gln 
            340                 345                 350         


Arg Ile Leu Asp Asp Pro Ser Pro Ala Cys Pro His Glu Glu His Leu 
        355                 360                 365             


Ala Ala Leu Thr Ala Ala Pro Arg Gly Thr Trp Ala Gln Val Arg Thr 
    370                 375                 380                 


Ser Leu Lys Thr Gln Ala Ala Glu Ala Leu Glu Ala Val Glu Gly Ala 
385                 390                 395                 400 


Ala Phe Phe Val Ser Leu Asp Ala Glu Pro Ala Gly Leu Thr Arg Glu 
                405                 410                 415     


Asp Pro Ala Ala Ser Leu Asp Ala Tyr Ala His Ala Leu Leu Ala Gly 
            420                 425                 430         


Arg Gly His Asp Arg Trp Phe Asp Lys Ser Phe Thr Leu Ile Val Phe 
        435                 440                 445             


Ser Asn Gly Lys Leu Gly Leu Ser Val Glu His Ser Trp Ala Asp Cys 
    450                 455                 460                 


Pro Ile Ser Gly His Met Trp Glu Phe Thr Leu Ala Thr Glu Cys Phe 
465                 470                 475                 480 


Gln Leu Gly Tyr Ser Thr Asp Gly His Cys Lys Gly His Pro Asp Pro 
                485                 490                 495     


Thr Leu Pro Gln Pro Gln Arg Leu Gln Trp Asp Leu Pro Asp Gln Ile 
            500                 505                 510         


His Ser Ser Ile Ser Leu Ala Leu Arg Gly Ala Lys Ile Leu Ser Glu 
        515                 520                 525             


Asn Val Asp Cys His Val Val Pro Phe Ser Leu Phe Gly Lys Ser Phe 
    530                 535                 540                 


Ile Arg Arg Cys His Leu Ser Ser Asp Ser Phe Ile Gln Ile Ala Leu 
545                 550                 555                 560 


Gln Leu Ala His Phe Arg Asp Arg Gly Gln Phe Cys Leu Thr Tyr Glu 
                565                 570                 575     


Ser Ala Met Thr Arg Leu Phe Leu Glu Gly Arg Thr Glu Thr Val Arg 
            580                 585                 590         


Ser Cys Thr Arg Glu Ala Cys Asn Phe Val Arg Ala Met Glu Asp Lys 
        595                 600                 605             


Glu Lys Thr Asp Pro Gln Cys Leu Ala Leu Phe Arg Val Ala Val Asp 
    610                 615                 620                 


Lys His Gln Ala Leu Leu Lys Ala Ala Met Ser Gly Gln Gly Val Asp 
625                 630                 635                 640 


Arg His Leu Phe Ala Leu Tyr Ile Val Ser Arg Phe Leu His Leu Gln 
                645                 650                 655     


Ser Pro Phe Leu Thr Gln Val His Ser Glu Gln Trp Gln Leu Ser Thr 
            660                 665                 670         


Ser Gln Ile Pro Val Gln Gln Met His Leu Phe Asp Val His Asn Tyr 
        675                 680                 685             


Pro Asp Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Ala Asp Asp His 
    690                 695                 700                 


Gly Tyr Gly Val Ser Tyr Ile Phe Met Gly Asp Gly Met Ile Thr Phe 
705                 710                 715                 720 


His Ile Ser Ser Lys Lys Ser Ser Thr Lys Thr Asp Ser His Arg Leu 
                725                 730                 735     


Gly Gln His Ile Glu Asp Ala Leu Leu Asp Val Ala Ser Leu Phe Gln 
            740                 745                 750         


Ala Gly Gln His Phe Lys Arg Arg Phe Arg Gly Ser Gly Lys Glu Asn 
        755                 760                 765             


Ser Arg His Arg Cys Gly Phe Leu Ser Arg Gln Thr Gly Ala Ser Lys 
    770                 775                 780                 


Ala Ser Met Thr Ser Thr Asp Phe 
785                 790         


<210>  2547
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPVL__Homo_sapiens__XP_011513739

<400>  2547

Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 
1               5                   10                  15      


Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 
            20                  25                  30          


Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 
        35                  40                  45              


Ile Glu Ala Gly Lys Ile Gln Lys Gly Arg Glu Leu Ser Leu Val Gly 
    50                  55                  60                  


Pro Phe Pro Gly Leu Asn Met Lys Ser Tyr Ala Gly Phe Leu Thr Val 
65                  70                  75                  80  


Asn Lys Thr Tyr Asn Ser Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln 
                85                  90                  95      


Ile Gln Pro Glu Asp Ala Pro Val Val Leu Trp Leu Gln Gly Gly Pro 
            100                 105                 110         


Gly Gly Ser Ser Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val 
        115                 120                 125             


Val Thr Ser Asn Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr 
    130                 135                 140                 


Thr Leu Ser Met Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser 
145                 150                 155                 160 


Phe Thr Asp Asp Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala 
                165                 170                 175     


Arg Asp Leu Tyr Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu 
            180                 185                 190         


Tyr Lys Asn Asn Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys 
        195                 200                 205             


Tyr Val Pro Ala Ile Ala His Leu Ile His Ser Leu Asn Pro Val Arg 
    210                 215                 220                 


Glu Val Lys Ile Asn Leu Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser 
225                 230                 235                 240 


Asp Pro Glu Ser Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile 
                245                 250                 255     


Gly Leu Leu Asp Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His 
            260                 265                 270         


Glu Cys Ile Glu His Ile Arg Lys Gln Asn Trp Phe Glu Ala Phe Glu 
        275                 280                 285             


Ile Leu Asp Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr 
    290                 295                 300                 


Phe Gln Asn Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys 
305                 310                 315                 320 


Thr Glu Pro Glu Asp Gln Leu Tyr Tyr Val Lys Phe Leu Ser Leu Pro 
                325                 330                 335     


Glu Val Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly 
            340                 345                 350         


Thr Ile Val Glu Lys Tyr Leu Arg Glu Asp Thr Val Gln Ser Val Lys 
        355                 360                 365             


Pro Trp Leu Thr Glu Ile Met Asn Asn Tyr Lys Val Leu Ile Tyr Asn 
    370                 375                 380                 


Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser Leu 
385                 390                 395                 400 


Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu Lys 
                405                 410                 415     


Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr Ile 
            420                 425                 430         


Arg Gln Ala Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly His 
        435                 440                 445             


Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn Arg 
    450                 455                 460                 


Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 
465                 470                 475     


<210>  2548
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPXCR1__Homo_sapiens__NP_001171700

<400>  2548

Met Ser Ser Pro Thr Lys Glu Gly Ser Asp Thr Ala Gly Asn Ala His 
1               5                   10                  15      


Lys Asn Ser Glu Asn Glu Pro Pro Asn Asp Cys Ser Thr Asp Ile Glu 
            20                  25                  30          


Ser Pro Ser Ala Asp Pro Asn Met Ile Tyr Gln Val Glu Thr Asn Pro 
        35                  40                  45              


Ile Asn Arg Glu Pro Gly Thr Ala Thr Ser Gln Glu Asp Val Val Pro 
    50                  55                  60                  


Gln Ala Ala Glu Asn Ser Glu Leu Glu Thr Glu Ile Gln Lys Asp Gln 
65                  70                  75                  80  


Arg Glu Glu Asp Leu Lys Glu Glu Leu Leu Leu Leu Gln Thr Pro Ile 
                85                  90                  95      


Pro Arg Lys Leu Val Ser His Lys Pro Leu Asn Asp Arg Ser Arg Ser 
            100                 105                 110         


His Ser Gly Lys Val Glu Met Lys Ala Asn Asn Phe Pro Ile Asn His 
        115                 120                 125             


Lys Thr Arg Phe Arg Leu Ser Thr Ser Trp Arg Val Pro Phe Ile Asn 
    130                 135                 140                 


Ser His Glu Ile Arg Ser Met Ile Leu His Leu Leu Cys Asp Arg Tyr 
145                 150                 155                 160 


Phe Ser Gln Ala Ala Gly Cys Gln Asn Thr Met Trp Val Lys Arg Lys 
                165                 170                 175     


Tyr Ile Ala Cys Leu Tyr His Pro Asn Ser Phe Thr His His Glu Arg 
            180                 185                 190         


Ala Ile Thr Phe Arg Arg Pro Ser Arg Val His Tyr Tyr Arg Pro Leu 
        195                 200                 205             


Thr Glu Arg Met Thr Ser Gly Lys Phe Cys Lys Ser Thr Asp Thr Lys 
    210                 215                 220                 


Gly Lys Cys Arg Phe Arg Ala Ile Val Arg Ser Val Leu Phe Val Ser 
225                 230                 235                 240 


Gln Ile Gln Ile Glu Ser Ile Phe Asn Ile Lys Gly Phe Val Asp Ile 
                245                 250                 255     


Leu Thr Tyr Ile His Thr Met Asn Val Met Ile Thr Asn Thr Asn Asn 
            260                 265                 270         


Gly Trp Lys Tyr Phe Cys Pro Ile Cys Gly Arg Leu Phe Asn Thr Tyr 
        275                 280                 285             


Ser Glu Leu Arg Gln His Ser Cys Ser Ser Ser Gly Asn 
    290                 295                 300     


<210>  2549
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CPZ__Homo_sapiens__NP_001014447

<400>  2549

Met Pro Pro Pro Pro Pro Leu Leu Leu Leu Thr Val Leu Val Val Ala 
1               5                   10                  15      


Ala Ala Arg Pro Gly Cys Glu Phe Glu Arg Asn Pro Ala Gly Glu Cys 
            20                  25                  30          


His Arg Pro Pro Ala Ala Asp Ser Ala Thr Cys Val Asp Leu Gln Leu 
        35                  40                  45              


Arg Thr Cys Ser Asp Ala Ala Tyr Asn His Thr Thr Phe Pro Asn Leu 
    50                  55                  60                  


Leu Gln His Arg Ser Trp Glu Val Val Glu Ala Ser Ser Glu Tyr Ile 
65                  70                  75                  80  


Leu Leu Ser Val Leu His Gln Leu Leu Glu Gly Gln Cys Asn Pro Asp 
                85                  90                  95      


Leu Arg Leu Leu Gly Cys Ala Val Leu Ala Pro Arg Cys Glu Gly Gly 
            100                 105                 110         


Trp Val Arg Arg Pro Cys Arg His Ile Cys Glu Gly Leu Arg Glu Val 
        115                 120                 125             


Cys Gln Pro Ala Phe Asp Ala Ile Asp Met Ala Trp Pro Tyr Phe Leu 
    130                 135                 140                 


Asp Cys His Arg Tyr Phe Thr Arg Glu Asp Glu Gly Cys Tyr Asp Pro 
145                 150                 155                 160 


Leu Glu Lys Leu Arg Gly Gly Leu Glu Ala Asp Glu Ala Leu Pro Ser 
                165                 170                 175     


Gly Leu Pro Pro Thr Phe Ile Arg Phe Ser His His Ser Tyr Ala Gln 
            180                 185                 190         


Met Val Arg Val Leu Arg Arg Thr Ala Ser Arg Cys Ala His Val Ala 
        195                 200                 205             


Arg Thr Tyr Ser Ile Gly Arg Ser Phe Asp Gly Arg Glu Leu Leu Val 
    210                 215                 220                 


Ile Glu Phe Ser Ser Arg Pro Gly Gln His Glu Leu Met Glu Pro Glu 
225                 230                 235                 240 


Val Lys Leu Ile Gly Asn Ile His Gly Asn Glu Val Ala Gly Arg Glu 
                245                 250                 255     


Met Leu Ile Tyr Leu Ala Gln Tyr Leu Cys Ser Glu Tyr Leu Leu Gly 
            260                 265                 270         


Asn Pro Arg Ile Gln Arg Leu Leu Asn Thr Thr Arg Ile His Leu Leu 
        275                 280                 285             


Pro Ser Met Asn Pro Asp Gly Tyr Glu Val Ala Ala Ala Glu Gly Ala 
    290                 295                 300                 


Gly Tyr Asn Gly Trp Thr Ser Gly Arg Gln Asn Ala Gln Asn Leu Asp 
305                 310                 315                 320 


Leu Asn Arg Asn Phe Pro Asp Leu Thr Ser Glu Tyr Tyr Arg Leu Ala 
                325                 330                 335     


Glu Thr Arg Gly Ala Arg Ser Asp His Ile Pro Ile Pro Gln His Tyr 
            340                 345                 350         


Trp Trp Gly Lys Val Ala Pro Glu Thr Lys Ala Ile Met Lys Trp Met 
        355                 360                 365             


Gln Thr Ile Pro Phe Val Leu Ser Ala Ser Leu His Gly Gly Asp Leu 
    370                 375                 380                 


Val Val Ser Tyr Pro Phe Asp Phe Ser Lys His Pro Gln Glu Glu Lys 
385                 390                 395                 400 


Met Phe Ser Pro Thr Pro Asp Glu Lys Met Phe Lys Leu Leu Ser Arg 
                405                 410                 415     


Ala Tyr Ala Asp Val His Pro Met Met Met Asp Arg Ser Glu Asn Arg 
            420                 425                 430         


Cys Gly Gly Asn Phe Leu Lys Arg Gly Ser Ile Ile Asn Gly Ala Asp 
        435                 440                 445             


Trp Tyr Ser Phe Thr Gly Gly Met Ser Asp Phe Asn Tyr Leu His Thr 
    450                 455                 460                 


Asn Cys Phe Glu Ile Thr Val Glu Leu Gly Cys Val Lys Phe Pro Pro 
465                 470                 475                 480 


Glu Glu Ala Leu Tyr Thr Leu Trp Gln His Asn Lys Glu Ser Leu Leu 
                485                 490                 495     


Asn Phe Val Glu Thr Val His Arg Gly Ile Lys Gly Val Val Thr Asp 
            500                 505                 510         


Lys Phe Gly Lys Pro Val Lys Asn Ala Arg Ile Ser Val Lys Gly Ile 
        515                 520                 525             


Arg His Asp Ile Thr Thr Ala Pro Asp Gly Asp Tyr Trp Arg Leu Leu 
    530                 535                 540                 


Pro Pro Gly Ile His Ile Val Ile Ala Gln Ala Pro Gly Tyr Ala Lys 
545                 550                 555                 560 


Val Ile Lys Lys Val Ile Ile Pro Ala Arg Met Lys Arg Ala Gly Arg 
                565                 570                 575     


Val Asp Phe Ile Leu Gln Pro Leu Gly Met Gly Pro Lys Asn Phe Ile 
            580                 585                 590         


His Gly Leu Arg Arg Thr Gly Pro His Asp Pro Leu Gly Gly Ala Ser 
        595                 600                 605             


Ser Leu Gly Glu Ala Thr Glu Pro Asp Pro Leu Arg Ala Arg Arg Gln 
    610                 615                 620                 


Pro Ser Ala Asp Gly Ser Lys Pro Trp Trp Trp Ser Tyr Phe Thr Ser 
625                 630                 635                 640 


Leu Ser Thr His Arg Pro Arg Trp Leu Leu Lys Tyr 
                645                 650         


<210>  2550
<211>  2039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR1__Homo_sapiens__NP_000564

<400>  2550

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Thr  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2015                 2020                 2025             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210>  2551
<211>  1092
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR2__Homo_sapiens__NP_001006659

<400>  2551

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Gly Cys Gln Ser Pro Pro Gly Leu His His Gly Arg His 
            660                 665                 670         


Thr Gly Gly Asn Thr Val Phe Phe Val Ser Gly Met Thr Val Asp Tyr 
        675                 680                 685             


Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys 
    690                 695                 700                 


Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Thr 
705                 710                 715                 720 


Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg 
                725                 730                 735     


Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly 
            740                 745                 750         


His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys 
        755                 760                 765             


Lys Ile Pro Leu Cys Lys Val Ile His Cys His Pro Pro Pro Val Ile 
    770                 775                 780                 


Val Asn Gly Lys His Thr Gly Met Met Ala Glu Asn Phe Leu Tyr Gly 
785                 790                 795                 800 


Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu 
                805                 810                 815     


Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly His Gly Ser Trp Ser 
            820                 825                 830         


Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro Val Thr Arg Cys Pro 
        835                 840                 845             


Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala 
    850                 855                 860                 


Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile 
865                 870                 875                 880 


Met Asn Gly Ser Arg Val Ile Arg Cys His Thr Asp Asn Thr Trp Val 
                885                 890                 895     


Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro 
            900                 905                 910         


Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg 
        915                 920                 925             


Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu 
    930                 935                 940                 


Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His Glu Gly Thr Trp Ser 
945                 950                 955                 960 


Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp 
                965                 970                 975     


Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr 
            980                 985                 990         


Gly Ala Val Val Thr Leu Glu Cys  Glu Asp Gly Tyr Met  Leu Glu Gly 
        995                 1000                 1005             


Ser Pro  Gln Ser Gln Cys Gln  Ser Asp His Gln Trp  Asn Pro Pro 
    1010                 1015                 1020             


Leu Ala  Val Cys Arg Ser Arg  Ser Leu Ala Pro Val  Leu Cys Gly 
    1025                 1030                 1035             


Ile Ala  Ala Gly Leu Ile Leu  Leu Thr Phe Leu Ile  Val Ile Thr 
    1040                 1045                 1050             


Leu Tyr  Val Ile Ser Lys His  Arg Ala Arg Asn Tyr  Tyr Thr Asp 
    1055                 1060                 1065             


Thr Ser  Gln Lys Glu Ala Phe  His Leu Glu Ala Arg  Glu Val Tyr 
    1070                 1075                 1080             


Ser Val  Asp Pro Tyr Asn Pro  Ala Ser 
    1085                 1090         


<210>  2552
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRABP1__Homo_sapiens__NP_004369

<400>  2552

Met Pro Asn Phe Ala Gly Thr Trp Lys Met Arg Ser Ser Glu Asn Phe 
1               5                   10                  15      


Asp Glu Leu Leu Lys Ala Leu Gly Val Asn Ala Met Leu Arg Lys Val 
            20                  25                  30          


Ala Val Ala Ala Ala Ser Lys Pro His Val Glu Ile Arg Gln Asp Gly 
        35                  40                  45              


Asp Gln Phe Tyr Ile Lys Thr Ser Thr Thr Val Arg Thr Thr Glu Ile 
    50                  55                  60                  


Asn Phe Lys Val Gly Glu Gly Phe Glu Glu Glu Thr Val Asp Gly Arg 
65                  70                  75                  80  


Lys Cys Arg Ser Leu Ala Thr Trp Glu Asn Glu Asn Lys Ile His Cys 
                85                  90                  95      


Thr Gln Thr Leu Leu Glu Gly Asp Gly Pro Lys Thr Tyr Trp Thr Arg 
            100                 105                 110         


Glu Leu Ala Asn Asp Glu Leu Ile Leu Thr Phe Gly Ala Asp Asp Val 
        115                 120                 125             


Val Cys Thr Arg Ile Tyr Val Arg Glu 
    130                 135         


<210>  2553
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRABP2__Homo_sapiens__NP_001186652

<400>  2553

Met Pro Asn Phe Ser Gly Asn Trp Lys Ile Ile Arg Ser Glu Asn Phe 
1               5                   10                  15      


Glu Glu Leu Leu Lys Val Leu Gly Val Asn Val Met Leu Arg Lys Ile 
            20                  25                  30          


Ala Val Ala Ala Ala Ser Lys Pro Ala Val Glu Ile Lys Gln Glu Gly 
        35                  40                  45              


Asp Thr Phe Tyr Ile Lys Thr Ser Thr Thr Val Arg Thr Thr Glu Ile 
    50                  55                  60                  


Asn Phe Lys Val Gly Glu Glu Phe Glu Glu Gln Thr Val Asp Gly Arg 
65                  70                  75                  80  


Pro Cys Lys Ser Leu Val Lys Trp Glu Ser Glu Asn Lys Met Val Cys 
                85                  90                  95      


Glu Gln Lys Leu Leu Lys Gly Glu Gly Pro Lys Thr Ser Trp Thr Arg 
            100                 105                 110         


Glu Leu Thr Asn Asp Gly Glu Leu Ile Leu Thr Met Thr Ala Asp Asp 
        115                 120                 125             


Val Val Cys Thr Arg Val Tyr Val Arg Glu 
    130                 135             


<210>  2554
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRACR2A__Homo_sapiens__NP_001138430

<400>  2554

Met Ala Ala Pro Asp Gly Arg Val Val Ser Arg Pro Gln Arg Leu Gly 
1               5                   10                  15      


Gln Gly Ser Gly Gln Gly Pro Lys Gly Ser Gly Ala Cys Leu His Pro 
            20                  25                  30          


Leu Asp Ser Leu Glu Gln Lys Glu Thr Gln Glu Gln Thr Ser Gly Gln 
        35                  40                  45              


Leu Val Met Leu Arg Lys Ala Gln Glu Phe Phe Gln Thr Cys Asp Ala 
    50                  55                  60                  


Glu Gly Lys Gly Phe Ile Ala Arg Lys Asp Met Gln Arg Leu His Lys 
65                  70                  75                  80  


Glu Leu Pro Leu Ser Leu Glu Glu Leu Glu Asp Val Phe Asp Ala Leu 
                85                  90                  95      


Asp Ala Asp Gly Asn Gly Tyr Leu Thr Pro Gln Glu Phe Thr Thr Gly 
            100                 105                 110         


Phe Ser His Phe Phe Phe Ser Gln Asn Asn Pro Ser Gln Glu Asp Ala 
        115                 120                 125             


Gly Glu Gln Val Ala Gln Arg His Glu Glu Lys Val Tyr Leu Ser Arg 
    130                 135                 140                 


Gly Asp Glu Asp Leu Gly Asp Met Gly Glu Asp Glu Glu Ala Gln Phe 
145                 150                 155                 160 


Arg Met Leu Met Asp Arg Leu Gly Ala Gln Lys Val Leu Glu Asp Glu 
                165                 170                 175     


Ser Asp Val Lys Gln Leu Trp Leu Gln Leu Lys Lys Glu Glu Pro His 
            180                 185                 190         


Leu Leu Ser Asn Phe Glu Asp Phe Leu Thr Arg Ile Ile Ser Gln Leu 
        195                 200                 205             


Gln Glu Ala His Glu Glu Lys Asn Glu Leu Glu Cys Ala Leu Lys Arg 
    210                 215                 220                 


Lys Ile Ala Ala Tyr Asp Glu Glu Ile Gln His Leu Tyr Glu Glu Met 
225                 230                 235                 240 


Glu Gln Gln Ile Lys Ser Glu Lys Glu Gln Phe Leu Leu Lys Asp Thr 
                245                 250                 255     


Glu Arg Phe Gln Ala Arg Ser Gln Glu Leu Glu Gln Lys Leu Leu Cys 
            260                 265                 270         


Lys Glu Gln Glu Leu Glu Gln Leu Thr Gln Lys Gln Lys Arg Leu Glu 
        275                 280                 285             


Gly Gln Cys Thr Ala Leu His His Asp Lys His Glu Thr Lys Ala Glu 
    290                 295                 300                 


Asn Thr Lys Leu Lys Leu Thr Asn Gln Glu Leu Ala Arg Glu Leu Glu 
305                 310                 315                 320 


Arg Thr Ser Trp Glu Leu Gln Asp Ala Gln Gln Gln Leu Glu Ser Leu 
                325                 330                 335     


Gln Gln Glu Ala Cys Lys Leu His Gln Glu Lys Glu Met Glu Val Tyr 
            340                 345                 350         


Arg Val Thr Glu Ser Leu Gln Arg Glu Lys Ala Gly Leu Leu Lys Gln 
        355                 360                 365             


Leu Asp Phe Leu Arg Glu Arg Asn Lys His Leu Arg Asp Glu Arg Asp 
    370                 375                 380                 


Ile Cys Phe Gln Lys Asn Lys Ala Ala Lys Ala Asn Thr Ala Ala Ser 
385                 390                 395                 400 


Arg Ala Ser Trp Lys Lys Arg Ser Gly Ser Val Ile Gly Lys Tyr Val 
                405                 410                 415     


Asp Ser Arg Gly Ile Leu Arg Ser Gln Ser Glu Glu Glu Glu Glu Val 
            420                 425                 430         


Phe Gly Ile Pro Arg Arg Ser Ser Leu Gly Leu Ser Gly Tyr Pro Leu 
        435                 440                 445             


Thr Glu Glu Glu Pro Gly Thr Gly Glu Pro Gly Pro Gly Gly Pro Tyr 
    450                 455                 460                 


Pro Arg Pro Leu Arg Arg Ile Ile Ser Val Glu Glu Asp Pro Leu Pro 
465                 470                 475                 480 


Gln Leu Leu Asp Gly Gly Phe Glu Gln Pro Leu Ser Lys Cys Ser Glu 
                485                 490                 495     


Glu Glu Glu Val Ser Asp Gln Gly Val Gln Gly Gln Ile Pro Glu Ala 
            500                 505                 510         


Pro Pro Leu Lys Leu Thr Pro Thr Ser Pro Arg Gly Gln Pro Val Gly 
        515                 520                 525             


Lys Glu Ala Leu Cys Lys Glu Glu Ser Ser Pro Ser Ala Pro Asp Arg 
    530                 535                 540                 


Leu Phe Lys Ile Val Phe Val Gly Asn Ser Ala Val Gly Lys Thr Ser 
545                 550                 555                 560 


Phe Leu Arg Arg Phe Cys Glu Asp Arg Phe Ser Pro Gly Met Ala Ala 
                565                 570                 575     


Thr Val Gly Ile Asp Tyr Arg Val Lys Thr Leu Asn Val Asp Asn Ser 
            580                 585                 590         


Gln Val Ala Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg 
        595                 600                 605             


Cys Ile Thr Gln Gln Phe Phe Arg Lys Ala Asp Gly Val Ile Val Met 
    610                 615                 620                 


Tyr Asp Leu Thr Asp Lys Gln Ser Phe Leu Ser Val Arg Arg Trp Leu 
625                 630                 635                 640 


Ser Ser Val Glu Glu Ala Val Gly Asp Arg Val Pro Val Leu Leu Leu 
                645                 650                 655     


Gly Asn Lys Leu Asp Asn Glu Lys Glu Arg Glu Val Pro Arg Gly Leu 
            660                 665                 670         


Gly Glu Gln Leu Ala Thr Glu Asn Asn Leu Ile Phe Tyr Glu Cys Ser 
        675                 680                 685             


Ala Tyr Ser Gly His Asn Thr Lys Glu Ser Leu Leu His Leu Ala Arg 
    690                 695                 700                 


Phe Leu Lys Glu Gln Glu Asp Thr Val Arg Glu Asp Thr Ile Gln Val 
705                 710                 715                 720 


Gly His Pro Ala Lys Lys Lys Ser Cys Cys Gly 
                725                 730     


<210>  2555
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRADD__Homo_sapiens__NP_003796

<400>  2555

Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Thr Glu Asn His Ile Gln Glu Ile Asn Ala Gln Thr 
        35                  40                  45              


Thr Gly Leu Arg Lys Thr Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Thr Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Thr Asp 
                85                  90                  95      


Leu Pro Ala Gly Asp Arg Leu Thr Gly Ile Pro Ser His Ile Leu Asn 
            100                 105                 110         


Ser Ser Pro Ser Asp Arg Gln Ile Asn Gln Leu Ala Gln Arg Leu Gly 
        115                 120                 125             


Pro Glu Trp Glu Pro Met Val Leu Ser Leu Gly Leu Ser Gln Thr Asp 
    130                 135                 140                 


Ile Tyr Arg Cys Lys Ala Asn His Pro His Asn Val Gln Ser Gln Val 
145                 150                 155                 160 


Val Glu Ala Phe Ile Arg Trp Arg Gln Arg Phe Gly Lys Gln Ala Thr 
                165                 170                 175     


Phe Gln Ser Leu His Asn Gly Leu Arg Ala Val Glu Val Asp Pro Ser 
            180                 185                 190         


Leu Leu Leu His Met Leu Glu 
        195                 


<210>  2556
<211>  1269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRAMP1L__Homo_sapiens__NP_065876

<400>  2556

Met Thr Val Lys Leu Gly Asp Gly Gly Ser Gly Glu Asp Gly Leu Lys 
1               5                   10                  15      


Lys Leu Gly Lys Arg Ala Ala Asp Glu Glu Ser Leu Glu Gly Glu Gly 
            20                  25                  30          


Ala Gly Gly Ala Asp Ala Ala Glu Glu Ser Ser Gly Thr Lys Arg Asp 
        35                  40                  45              


Glu Lys Thr Pro Arg Ala Gly Ala Asp Gly Pro Pro Ala Pro Pro Gly 
    50                  55                  60                  


Ala Pro Gln Ala Pro Ser Pro Pro Gln Gly Ser Pro Gln Asp Gln His 
65                  70                  75                  80  


His Phe Leu Arg Ser Ser Val Arg Pro Gln Ser Lys Arg Pro Arg Lys 
                85                  90                  95      


Asp Pro Pro Ser Ala Val Gly Ser Gly Asn Ala Gly Gly Ser Gly Pro 
            100                 105                 110         


Arg Gly Lys Gly Ala Glu Gly Gly Gly Ser Ser Ser Gly Asn Val Ser 
        115                 120                 125             


Gly Val Ala Pro Ala Ala Pro Ala Gly Gly Ser Arg Ser Ser Ser Arg 
    130                 135                 140                 


Asn Leu Gly Ser Ser Gly Gly Glu Lys Glu Glu Gly Lys Lys Val Arg 
145                 150                 155                 160 


Arg Gln Trp Glu Ser Trp Ser Thr Glu Asp Lys Asn Thr Phe Phe Glu 
                165                 170                 175     


Gly Leu Tyr Glu His Gly Lys Asp Phe Glu Ala Ile Gln Asn Asn Ile 
            180                 185                 190         


Ala Leu Lys Tyr Lys Lys Lys Gly Lys Pro Ala Ser Met Val Lys Asn 
        195                 200                 205             


Lys Glu Gln Val Arg His Phe Tyr Tyr Arg Thr Trp His Lys Ile Thr 
    210                 215                 220                 


Lys Tyr Ile Asp Phe Asp His Val Phe Ser Arg Gly Leu Lys Lys Ser 
225                 230                 235                 240 


Ser Gln Glu Leu Tyr Gly Leu Ile Cys Tyr Gly Glu Leu Arg Lys Lys 
                245                 250                 255     


Ile Gly Gly Cys Met Asp Asp Lys Asn Ala Thr Lys Leu Asn Glu Leu 
            260                 265                 270         


Ile Gln Val Gly Ala Thr Thr Val Arg Tyr Lys Gly Arg Asn Leu Arg 
        275                 280                 285             


Ile Lys Ala Pro Met Cys Arg Ala Leu Lys Lys Leu Cys Asp Pro Asp 
    290                 295                 300                 


Gly Leu Ser Asp Glu Glu Asp Gln Lys Pro Val Arg Leu Pro Leu Lys 
305                 310                 315                 320 


Val Pro Ile Glu Leu Gln Pro Arg Asn Asn His Ala Trp Ala Arg Val 
                325                 330                 335     


Gln Ser Leu Ala Gln Asn Pro Arg Leu Arg Met Ile Val Glu Leu His 
            340                 345                 350         


Arg Lys Val Ser Ser Leu Ile Glu Phe Leu Lys Gln Lys Trp Ala Leu 
        355                 360                 365             


His Glu Val Arg Val Arg Lys Thr Leu Glu Glu Arg Gln Leu Gln Asp 
    370                 375                 380                 


Ser Cys Ser Ala Pro Met Gln Glu Lys Val Thr Leu His Leu Phe Pro 
385                 390                 395                 400 


Gly Glu Asn Cys Thr Leu Thr Pro Leu Pro Gly Val Ala Arg Val Val 
                405                 410                 415     


His Ser Lys Ala Phe Cys Thr Val His Trp Gln Glu Gly Gly Arg Cys 
            420                 425                 430         


Lys Gln Ser Ala Lys Asp Ala His Val Leu Pro Pro Ala Gln Ile Leu 
        435                 440                 445             


Gly Ile Gln Ser Gly Gln Gly Thr Ala Arg Gly Gln Val Lys Cys Pro 
    450                 455                 460                 


Arg Ser Gly Ala Glu Gly Lys Gly Val Gly Arg Pro Pro Pro Ala Ala 
465                 470                 475                 480 


Asp Ala Leu Gln Ser Ser Gly Glu Ser Ser Pro Glu Ser Ala Pro Gly 
                485                 490                 495     


Glu Gly Ala Ala Leu Ser Leu Ser Ser Pro Asp Ala Pro Asp Arg Pro 
            500                 505                 510         


Pro Pro Arg His Gln Asp Thr Gly Pro Cys Leu Glu Lys Thr Pro Ala 
        515                 520                 525             


Glu Gly Arg Asp Ser Pro Thr Arg Glu Pro Gly Ala Leu Pro Cys Ala 
    530                 535                 540                 


Cys Gly Gln Leu Pro Asp Leu Glu Asp Glu Leu Ser Leu Leu Asp Pro 
545                 550                 555                 560 


Leu Pro Arg Tyr Leu Lys Ser Cys Gln Asp Leu Ile Val Pro Glu Gln 
                565                 570                 575     


Cys Arg Cys Ala Asp Thr Arg Pro Gly Ser Glu Gln Pro Pro Leu Gly 
            580                 585                 590         


Gly Ala Ala Ser Pro Glu Val Leu Ala Pro Val Ser Lys Glu Ala Ala 
        595                 600                 605             


Asp Leu Ala Pro Thr Gly Pro Ser Pro Arg Pro Gly Pro Gly Leu Leu 
    610                 615                 620                 


Leu Asp Val Cys Thr Lys Asp Leu Ala Asp Ala Pro Ala Glu Glu Leu 
625                 630                 635                 640 


Gln Glu Lys Gly Ser Pro Ala Gly Pro Pro Pro Ser Gln Gly Gln Pro 
                645                 650                 655     


Ala Ala Arg Pro Pro Lys Glu Val Pro Ala Ser Arg Leu Ala Gln Gln 
            660                 665                 670         


Leu Arg Glu Glu Gly Trp Asn Leu Gln Thr Ser Glu Ser Leu Thr Leu 
        675                 680                 685             


Ala Glu Val Tyr Leu Met Met Gly Lys Pro Ser Lys Leu Gln Leu Glu 
    690                 695                 700                 


Tyr Asp Trp Leu Gly Pro Gly Arg Gln Asp Pro Arg Pro Gly Ser Leu 
705                 710                 715                 720 


Pro Thr Ala Leu His Lys Gln Arg Leu Leu Ser Cys Leu Leu Lys Leu 
                725                 730                 735     


Ile Ser Thr Glu Val Asn Pro Lys Leu Ala Leu Glu Ala Asn Thr Ile 
            740                 745                 750         


Ser Thr Ala Ser Val Arg Pro Ala Gln Glu Glu Gln Ser Met Thr Pro 
        755                 760                 765             


Pro Gly Lys Val Val Thr Val Ser Ser Arg Ser Pro Arg Cys Pro Arg 
    770                 775                 780                 


Asn Gln Ala Ser Leu Arg Ser Ser Lys Thr Phe Pro Pro Ser Ser Ala 
785                 790                 795                 800 


Pro Cys Ser Ser Gly Leu Arg Asn Pro Pro Arg Pro Leu Leu Val Pro 
                805                 810                 815     


Gly Pro Ser Ser Thr Gly Ser Asn Asp Ser Asp Gly Gly Leu Phe Ala 
            820                 825                 830         


Val Pro Thr Thr Leu Pro Pro Asn Ser Arg His Gly Lys Leu Phe Ser 
        835                 840                 845             


Pro Ser Lys Glu Ala Glu Leu Thr Phe Arg Gln His Leu Asn Ser Ile 
    850                 855                 860                 


Ser Met Gln Ser Asp Phe Phe Leu Pro Lys Pro Arg Lys Leu Arg Asn 
865                 870                 875                 880 


Arg His Leu Arg Lys Pro Leu Val Val Gln Arg Thr Leu Leu Pro Arg 
                885                 890                 895     


Pro Ser Glu Asn Gln Ser His Asn Val Cys Ser Phe Ser Ile Leu Ser 
            900                 905                 910         


Asn Ser Ser Val Thr Gly Arg Gly Ser Phe Arg Pro Ile Gln Ser Ser 
        915                 920                 925             


Leu Thr Lys Ala Ala Leu Ser Arg Pro Ile Val Pro Lys Val Leu Pro 
    930                 935                 940                 


Pro Gln Ala Thr Ser His Leu Ala Ser Ala Ile Asp Leu Ala Ala Thr 
945                 950                 955                 960 


Ser Ala Gly Ile Leu Ser Gly Asn Pro Leu Pro Ala Leu Asp Thr Glu 
                965                 970                 975     


Gly Leu Ser Gly Ile Ser Pro Leu Ser Ser Asp Glu Val Thr Gly Ala 
            980                 985                 990         


Ile Ser Gly Gln Asp Ser Thr Gly  Thr His Gln Asp Gly  Asp Thr Leu 
        995                 1000                 1005             


Pro Thr  Val Gly Gly Ser Asp  Pro Phe Val Ser Ile  Pro Ser Arg 
    1010                 1015                 1020             


Pro Glu  Gln Glu Pro Val Ala  Asp Ser Phe Gln Gly  Ser Ser Val 
    1025                 1030                 1035             


Leu Ser  Leu Ser Glu Leu Pro  Lys Ala Pro Leu Gln  Asn Gly Leu 
    1040                 1045                 1050             


Ser Ile  Pro Leu Ser Ser Ser  Glu Ser Ser Ser Thr  Arg Leu Ser 
    1055                 1060                 1065             


Pro Pro  Asp Val Ser Ala Leu  Leu Asp Ile Ser Leu  Pro Gly Pro 
    1070                 1075                 1080             


Pro Glu  Asp Ala Leu Ser Gln  Gly Glu Pro Ala Thr  His Ile Ser 
    1085                 1090                 1095             


Asp Ser  Ile Ile Glu Ile Ala  Ile Ser Ser Gly Gln  Tyr Gly Glu 
    1100                 1105                 1110             


Gly Val  Pro Leu Ser Pro Ala  Lys Leu Asn Gly Ser  Asp Ser Ser 
    1115                 1120                 1125             


Lys Ser  Leu Pro Ser Pro Ser  Ser Ser Pro Gln Pro  His Trp Ile 
    1130                 1135                 1140             


Ala Ser  Pro Thr His Asp Pro  Gln Trp Tyr Pro Ser  Asp Ser Thr 
    1145                 1150                 1155             


Asp Ser  Ser Leu Ser Ser Leu  Phe Ala Ser Phe Ile  Ser Pro Glu 
    1160                 1165                 1170             


Lys Ser  Arg Lys Met Leu Pro  Thr Pro Ile Gly Thr  Asn Ser Gly 
    1175                 1180                 1185             


Thr Ser  Leu Leu Gly Pro Ser  Leu Leu Asp Gly Asn  Ser Arg Asp 
    1190                 1195                 1200             


Ser Phe  Val Ser Arg Ser Leu  Ala Asp Val Ala Glu  Val Val Asp 
    1205                 1210                 1215             


Ser Gln  Leu Val Cys Met Met  Asn Glu Asn Ser Ile  Asp Tyr Ile 
    1220                 1225                 1230             


Ser Arg  Phe Asn Asp Leu Ala  Gln Glu Leu Ser Ile  Ala Glu Pro 
    1235                 1240                 1245             


Gly Arg  Arg Glu Ala Leu Phe  Asp Gly Gly Gly Gly  Gly Pro Ala 
    1250                 1255                 1260             


Val Ser  Asp Leu Ser Gln 
    1265                 


<210>  2557
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRAT__Homo_sapiens__NP_000746

<400>  2557

Met Leu Ala Phe Ala Ala Arg Thr Val Val Lys Pro Leu Gly Phe Leu 
1               5                   10                  15      


Lys Pro Phe Ser Leu Met Lys Ala Ser Ser Arg Phe Lys Ala His Gln 
            20                  25                  30          


Asp Ala Leu Pro Arg Leu Pro Val Pro Pro Leu Gln Gln Ser Leu Asp 
        35                  40                  45              


His Tyr Leu Lys Ala Leu Gln Pro Ile Val Ser Glu Glu Glu Trp Ala 
    50                  55                  60                  


His Thr Lys Gln Leu Val Asp Glu Phe Gln Ala Ser Gly Gly Val Gly 
65                  70                  75                  80  


Glu Arg Leu Gln Lys Gly Leu Glu Arg Arg Ala Arg Lys Thr Glu Asn 
                85                  90                  95      


Trp Leu Ser Glu Trp Trp Leu Lys Thr Ala Tyr Leu Gln Tyr Arg Gln 
            100                 105                 110         


Pro Val Val Ile Tyr Ser Ser Pro Gly Val Met Leu Pro Lys Gln Asp 
        115                 120                 125             


Phe Val Asp Leu Gln Gly Gln Leu Arg Phe Ala Ala Lys Leu Ile Glu 
    130                 135                 140                 


Gly Val Leu Asp Phe Lys Val Met Ile Asp Asn Glu Thr Leu Pro Val 
145                 150                 155                 160 


Glu Tyr Leu Gly Gly Lys Pro Leu Cys Met Asn Gln Tyr Tyr Gln Ile 
                165                 170                 175     


Leu Ser Ser Cys Arg Val Pro Gly Pro Lys Gln Asp Thr Val Ser Asn 
            180                 185                 190         


Phe Ser Lys Thr Lys Lys Pro Pro Thr His Ile Thr Val Val His Asn 
        195                 200                 205             


Tyr Gln Phe Phe Glu Leu Asp Val Tyr His Ser Asp Gly Thr Pro Leu 
    210                 215                 220                 


Thr Ala Asp Gln Ile Phe Val Gln Leu Glu Lys Ile Trp Asn Ser Ser 
225                 230                 235                 240 


Leu Gln Thr Asn Lys Glu Pro Val Gly Ile Leu Thr Ser Asn His Arg 
                245                 250                 255     


Asn Ser Trp Ala Lys Ala Tyr Asn Thr Leu Ile Lys Asp Lys Val Asn 
            260                 265                 270         


Arg Asp Ser Val Arg Ser Ile Gln Lys Ser Ile Phe Thr Val Cys Leu 
        275                 280                 285             


Asp Ala Thr Met Pro Arg Val Ser Glu Asp Val Tyr Arg Ser His Val 
    290                 295                 300                 


Ala Gly Gln Met Leu His Gly Gly Gly Ser Arg Leu Asn Ser Gly Asn 
305                 310                 315                 320 


Arg Trp Phe Asp Lys Thr Leu Gln Phe Ile Val Ala Glu Asp Gly Ser 
                325                 330                 335     


Cys Gly Leu Val Tyr Glu His Ala Ala Ala Glu Gly Pro Pro Ile Val 
            340                 345                 350         


Thr Leu Leu Asp Tyr Val Ile Glu Tyr Thr Lys Lys Pro Glu Leu Val 
        355                 360                 365             


Arg Ser Pro Met Val Pro Leu Pro Met Pro Lys Lys Leu Arg Phe Asn 
    370                 375                 380                 


Ile Thr Pro Glu Ile Lys Ser Asp Ile Glu Lys Ala Lys Gln Asn Leu 
385                 390                 395                 400 


Ser Ile Met Ile Gln Asp Leu Asp Ile Thr Val Met Val Phe His His 
                405                 410                 415     


Phe Gly Lys Asp Phe Pro Lys Ser Glu Lys Leu Ser Pro Asp Ala Phe 
            420                 425                 430         


Ile Gln Met Ala Leu Gln Leu Ala Tyr Tyr Arg Ile Tyr Gly Gln Ala 
        435                 440                 445             


Cys Ala Thr Tyr Glu Ser Ala Ser Leu Arg Met Phe His Leu Gly Arg 
    450                 455                 460                 


Thr Asp Thr Ile Arg Ser Ala Ser Met Asp Ser Leu Thr Phe Val Lys 
465                 470                 475                 480 


Ala Met Asp Asp Ser Ser Val Thr Glu His Gln Lys Val Glu Leu Leu 
                485                 490                 495     


Arg Lys Ala Val Gln Ala His Arg Gly Tyr Thr Asp Arg Ala Ile Arg 
            500                 505                 510         


Gly Glu Ala Phe Asp Arg His Leu Leu Gly Leu Lys Leu Gln Ala Ile 
        515                 520                 525             


Glu Asp Leu Val Ser Met Pro Asp Ile Phe Met Asp Thr Ser Tyr Ala 
    530                 535                 540                 


Ile Ala Met His Phe His Leu Ser Thr Ser Gln Val Pro Ala Lys Thr 
545                 550                 555                 560 


Asp Cys Val Met Phe Phe Gly Pro Val Val Pro Asp Gly Tyr Gly Val 
                565                 570                 575     


Cys Tyr Asn Pro Met Glu Ala His Ile Asn Phe Ser Leu Ser Ala Tyr 
            580                 585                 590         


Asn Ser Cys Ala Glu Thr Asn Ala Ala Arg Leu Ala His Tyr Leu Glu 
        595                 600                 605             


Lys Ala Leu Leu Asp Met Arg Ala Leu Leu Gln Ser His Pro Arg Ala 
    610                 615                 620                 


Lys Leu 
625     


<210>  2558
<211>  1294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRB1__Homo_sapiens__NP_001180569

<400>  2558

Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe 
1               5                   10                  15      


Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr 
            20                  25                  30          


Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe 
        35                  40                  45              


Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp 
    50                  55                  60                  


Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln 
65                  70                  75                  80  


Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys 
                85                  90                  95      


Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly 
            100                 105                 110         


Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp 
        115                 120                 125             


Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe 
    130                 135                 140                 


Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly 
145                 150                 155                 160 


Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro 
                165                 170                 175     


Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser 
            180                 185                 190         


Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr 
        195                 200                 205             


Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Tyr Thr Gly Ala Gln Cys 
    210                 215                 220                 


Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly 
225                 230                 235                 240 


Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly 
                245                 250                 255     


Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile 
            260                 265                 270         


Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu 
        275                 280                 285             


Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro 
    290                 295                 300                 


Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe 
305                 310                 315                 320 


Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln 
                325                 330                 335     


Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln 
            340                 345                 350         


His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys 
        355                 360                 365             


Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val 
    370                 375                 380                 


Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu 
385                 390                 395                 400 


Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn 
                405                 410                 415     


Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu 
            420                 425                 430         


Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His 
        435                 440                 445             


Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu 
    450                 455                 460                 


Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile 
465                 470                 475                 480 


Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe 
                485                 490                 495     


Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly 
            500                 505                 510         


Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val 
        515                 520                 525             


Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu 
    530                 535                 540                 


Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg 
545                 550                 555                 560 


Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile 
                565                 570                 575     


Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly 
            580                 585                 590         


Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp 
        595                 600                 605             


Ser Thr Gly Tyr Val Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr 
    610                 615                 620                 


Ile Ser Leu Ser Met Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu 
625                 630                 635                 640 


Leu Ala Leu Glu Asn Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu 
                645                 650                 655     


Arg Gly Arg Leu Ala Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val 
            660                 665                 670         


Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile 
        675                 680                 685             


Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe 
    690                 695                 700                 


Ile Ser Ala Ser Thr Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile 
705                 710                 715                 720 


Gly Gly Leu Pro Asp Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe 
                725                 730                 735     


Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe 
            740                 745                 750         


Phe Pro Asn Pro Thr Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn 
        755                 760                 765             


Val Thr Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys 
    770                 775                 780                 


His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser 
785                 790                 795                 800 


Cys Pro Ala Leu Thr Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys 
                805                 810                 815     


Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln 
            820                 825                 830         


Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln 
        835                 840                 845             


Ile Leu Phe Arg Ser Asn Gly Asn Ile Thr Arg Glu Leu Thr Asn Ile 
    850                 855                 860                 


Thr Phe Gly Phe Arg Thr Arg Asp Ala Asn Val Ile Ile Leu His Ala 
865                 870                 875                 880 


Glu Lys Glu Pro Glu Phe Leu Asn Ile Ser Ile Gln Asp Ser Arg Leu 
                885                 890                 895     


Phe Phe Gln Leu Gln Ser Gly Asn Ser Phe Tyr Met Leu Ser Leu Thr 
            900                 905                 910         


Ser Leu Gln Ser Val Asn Asp Gly Thr Trp His Glu Val Thr Leu Ser 
        915                 920                 925             


Met Thr Asp Pro Leu Ser Gln Thr Ser Arg Trp Gln Met Glu Val Asp 
    930                 935                 940                 


Asn Glu Thr Pro Phe Val Thr Ser Thr Ile Ala Thr Gly Ser Leu Asn 
945                 950                 955                 960 


Phe Leu Lys Asp Asn Thr Asp Ile Tyr Val Gly Asp Arg Ala Ile Asp 
                965                 970                 975     


Asn Ile Lys Gly Leu Gln Gly Cys Leu Ser Thr Ile Glu Ile Gly Gly 
            980                 985                 990         


Ile Tyr Leu Ser Tyr Phe Glu Asn  Val His Gly Phe Ile  Asn Lys Pro 
        995                 1000                 1005             


Gln Glu  Glu Gln Phe Leu Lys  Ile Ser Thr Asn Ser  Val Val Thr 
    1010                 1015                 1020             


Gly Cys  Leu Gln Leu Asn Val  Cys Asn Ser Asn Pro  Cys Leu His 
    1025                 1030                 1035             


Gly Gly  Asn Cys Glu Asp Ile  Tyr Ser Ser Tyr His  Cys Ser Cys 
    1040                 1045                 1050             


Pro Leu  Gly Trp Ser Gly Lys  His Cys Glu Leu Asn  Ile Asp Glu 
    1055                 1060                 1065             


Cys Phe  Ser Asn Pro Cys Ile  His Gly Asn Cys Ser  Asp Arg Val 
    1070                 1075                 1080             


Ala Ala  Tyr His Cys Thr Cys  Glu Pro Gly Tyr Thr  Gly Val Asn 
    1085                 1090                 1095             


Cys Glu  Val Asp Ile Asp Asn  Cys Gln Ser His Gln  Cys Ala Asn 
    1100                 1105                 1110             


Gly Ala  Thr Cys Ile Ser His  Thr Asn Gly Tyr Ser  Cys Leu Cys 
    1115                 1120                 1125             


Phe Gly  Asn Phe Thr Gly Lys  Phe Cys Arg Gln Ser  Arg Leu Pro 
    1130                 1135                 1140             


Ser Thr  Val Cys Gly Asn Glu  Lys Thr Asn Leu Thr  Cys Tyr Asn 
    1145                 1150                 1155             


Gly Gly  Asn Cys Thr Glu Phe  Gln Thr Glu Leu Lys  Cys Met Cys 
    1160                 1165                 1170             


Arg Pro  Gly Phe Thr Gly Glu  Trp Cys Glu Lys Asp  Ile Asp Glu 
    1175                 1180                 1185             


Cys Ala  Ser Asp Pro Cys Val  Asn Gly Gly Leu Cys  Gln Asp Leu 
    1190                 1195                 1200             


Leu Asn  Lys Phe Gln Cys Leu  Cys Asp Val Ala Phe  Ala Gly Glu 
    1205                 1210                 1215             


Arg Cys  Glu Val Asp Leu Ala  Asp Asp Leu Ile Ser  Asp Ile Phe 
    1220                 1225                 1230             


Thr Thr  Ile Gly Ser Val Thr  Val Ala Leu Leu Leu  Ile Leu Leu 
    1235                 1240                 1245             


Leu Ala  Ile Val Ala Ser Val  Val Thr Ser Asn Lys  Arg Ala Thr 
    1250                 1255                 1260             


Gln Gly  Thr Tyr Ser Pro Ser  Arg Gln Glu Lys Glu  Gly Ser Arg 
    1265                 1270                 1275             


Val Glu  Met Trp Asn Leu Met  Pro Pro Pro Ala Met  Glu Arg Leu 
    1280                 1285                 1290             


Ile 
    


<210>  2559
<211>  1285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRB2__Homo_sapiens__NP_775960

<400>  2559

Met Ala Leu Ala Arg Pro Gly Thr Pro Asp Pro Gln Ala Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Trp Ala Pro Ala Leu Ser Leu Leu Ala Gly 
            20                  25                  30          


Thr Val Pro Ser Glu Pro Pro Ser Ala Cys Ala Ser Asp Pro Cys Ala 
        35                  40                  45              


Pro Gly Thr Glu Cys Gln Ala Thr Glu Ser Gly Gly Tyr Thr Cys Gly 
    50                  55                  60                  


Pro Met Glu Pro Arg Gly Cys Ala Thr Gln Pro Cys His His Gly Ala 
65                  70                  75                  80  


Leu Cys Val Pro Gln Gly Pro Asp Pro Thr Gly Phe Arg Cys Tyr Cys 
                85                  90                  95      


Val Pro Gly Phe Gln Gly Pro Arg Cys Glu Leu Asp Ile Asp Glu Cys 
            100                 105                 110         


Ala Ser Arg Pro Cys His His Gly Ala Thr Cys Arg Asn Leu Ala Asp 
        115                 120                 125             


Arg Tyr Glu Cys His Cys Pro Leu Gly Tyr Ala Gly Val Thr Cys Glu 
    130                 135                 140                 


Met Glu Val Asp Glu Cys Ala Ser Ala Pro Cys Leu His Gly Gly Ser 
145                 150                 155                 160 


Cys Leu Asp Gly Val Gly Ser Phe Arg Cys Val Cys Ala Pro Gly Tyr 
                165                 170                 175     


Gly Gly Thr Arg Cys Gln Leu Asp Leu Asp Glu Cys Gln Ser Gln Pro 
            180                 185                 190         


Cys Ala His Gly Gly Thr Cys His Asp Leu Val Asn Gly Phe Arg Cys 
        195                 200                 205             


Asp Cys Ala Gly Thr Gly Tyr Glu Gly Thr His Cys Glu Arg Glu Val 
    210                 215                 220                 


Leu Glu Cys Ala Ser Ala Pro Cys Glu His Asn Ala Ser Cys Leu Glu 
225                 230                 235                 240 


Gly Leu Gly Ser Phe Arg Cys Leu Cys Trp Pro Gly Tyr Ser Gly Glu 
                245                 250                 255     


Leu Cys Glu Val Asp Glu Asp Glu Cys Ala Ser Ser Pro Cys Gln His 
            260                 265                 270         


Gly Gly Arg Cys Leu Gln Arg Ser Asp Pro Ala Leu Tyr Gly Gly Val 
        275                 280                 285             


Gln Ala Ala Phe Pro Gly Ala Phe Ser Phe Arg His Ala Ala Gly Phe 
    290                 295                 300                 


Leu Cys His Cys Pro Pro Gly Phe Glu Gly Ala Asp Cys Gly Val Glu 
305                 310                 315                 320 


Val Asp Glu Cys Ala Ser Arg Pro Cys Leu Asn Gly Gly His Cys Gln 
                325                 330                 335     


Asp Leu Pro Asn Gly Phe Gln Cys His Cys Pro Asp Gly Tyr Ala Gly 
            340                 345                 350         


Pro Thr Cys Glu Glu Asp Val Asp Glu Cys Leu Ser Asp Pro Cys Leu 
        355                 360                 365             


His Gly Gly Thr Cys Ser Asp Thr Val Ala Gly Tyr Ile Cys Arg Cys 
    370                 375                 380                 


Pro Glu Thr Trp Gly Gly Arg Asp Cys Ser Val Gln Leu Thr Gly Cys 
385                 390                 395                 400 


Gln Gly His Thr Cys Pro Leu Ala Ala Thr Cys Ile Pro Ile Phe Glu 
                405                 410                 415     


Ser Gly Val His Ser Tyr Val Cys His Cys Pro Pro Gly Thr His Gly 
            420                 425                 430         


Pro Phe Cys Gly Gln Asn Thr Thr Phe Ser Val Met Ala Gly Ser Pro 
        435                 440                 445             


Ile Gln Ala Ser Val Pro Ala Gly Gly Pro Leu Gly Leu Ala Leu Arg 
    450                 455                 460                 


Phe Arg Thr Thr Leu Pro Ala Gly Thr Leu Ala Thr Arg Asn Asp Thr 
465                 470                 475                 480 


Lys Glu Ser Leu Glu Leu Ala Leu Val Ala Ala Thr Leu Gln Ala Thr 
                485                 490                 495     


Leu Trp Ser Tyr Ser Thr Thr Val Leu Val Leu Arg Leu Pro Asp Leu 
            500                 505                 510         


Ala Leu Asn Asp Gly His Trp His Gln Val Glu Val Val Leu His Leu 
        515                 520                 525             


Ala Thr Leu Glu Leu Arg Leu Trp His Glu Gly Cys Pro Ala Arg Leu 
    530                 535                 540                 


Cys Val Ala Ser Gly Pro Val Ala Leu Ala Ser Thr Ala Ser Ala Thr 
545                 550                 555                 560 


Pro Leu Pro Ala Gly Ile Ser Ser Ala Gln Leu Gly Asp Ala Thr Phe 
                565                 570                 575     


Ala Gly Cys Leu Gln Asp Val Arg Val Asp Gly His Leu Leu Leu Pro 
            580                 585                 590         


Glu Asp Leu Gly Glu Asn Val Leu Leu Gly Cys Glu Arg Arg Glu Gln 
        595                 600                 605             


Cys Arg Pro Leu Pro Cys Val His Gly Gly Ser Cys Val Asp Leu Trp 
    610                 615                 620                 


Thr His Phe Arg Cys Asp Cys Ala Arg Pro His Arg Gly Pro Thr Cys 
625                 630                 635                 640 


Ala Asp Glu Ile Pro Ala Ala Thr Phe Gly Leu Gly Gly Ala Pro Ser 
                645                 650                 655     


Ser Ala Ser Phe Leu Leu Gln Glu Leu Pro Gly Pro Asn Leu Thr Val 
            660                 665                 670         


Ser Phe Leu Leu Arg Thr Arg Glu Ser Ala Gly Leu Leu Leu Gln Phe 
        675                 680                 685             


Ala Asn Asp Ser Ala Ala Gly Leu Thr Val Phe Leu Ser Glu Gly Arg 
    690                 695                 700                 


Ile Arg Ala Glu Val Pro Gly Ser Pro Ala Val Val Leu Pro Gly Arg 
705                 710                 715                 720 


Trp Asp Asp Gly Leu Arg His Leu Val Met Leu Ser Phe Gly Pro Asp 
                725                 730                 735     


Gln Leu Gln Asp Leu Gly Gln His Val His Val Gly Gly Arg Leu Leu 
            740                 745                 750         


Ala Ala Asp Ser Gln Pro Trp Gly Gly Pro Phe Arg Gly Cys Leu Gln 
        755                 760                 765             


Asp Leu Arg Leu Asp Gly Cys His Leu Pro Phe Phe Pro Leu Pro Leu 
    770                 775                 780                 


Asp Asn Ser Ser Gln Pro Ser Glu Leu Gly Gly Arg Gln Ser Trp Asn 
785                 790                 795                 800 


Leu Thr Ala Gly Cys Val Ser Glu Asp Met Cys Ser Pro Asp Pro Cys 
                805                 810                 815     


Phe Asn Gly Gly Thr Cys Leu Val Thr Trp Asn Asp Phe His Cys Thr 
            820                 825                 830         


Cys Pro Ala Asn Phe Thr Gly Pro Thr Cys Ala Gln Gln Leu Trp Cys 
        835                 840                 845             


Pro Gly Gln Pro Cys Leu Pro Pro Ala Thr Cys Glu Glu Val Pro Asp 
    850                 855                 860                 


Gly Phe Val Cys Val Ala Glu Ala Thr Phe Arg Glu Gly Pro Pro Ala 
865                 870                 875                 880 


Ala Phe Ser Gly His Asn Ala Ser Ser Gly Arg Leu Leu Gly Gly Leu 
                885                 890                 895     


Ser Leu Ala Phe Arg Thr Arg Asp Ser Glu Ala Trp Leu Leu Arg Ala 
            900                 905                 910         


Ala Ala Gly Ala Leu Glu Gly Val Trp Leu Ala Val Arg Asn Gly Ser 
        915                 920                 925             


Leu Ala Gly Gly Val Arg Gly Gly His Gly Leu Pro Gly Ala Val Leu 
    930                 935                 940                 


Pro Ile Pro Gly Pro Arg Val Ala Asp Gly Ala Trp His Arg Val Arg 
945                 950                 955                 960 


Leu Ala Met Glu Arg Pro Ala Ala Thr Thr Ser Arg Trp Leu Leu Trp 
                965                 970                 975     


Leu Asp Gly Ala Ala Thr Pro Val Ala Leu Arg Gly Leu Ala Ser Asp 
            980                 985                 990         


Leu Gly Phe Leu Gln Gly Pro Gly  Ala Val Arg Ile Leu  Leu Ala Glu 
        995                 1000                 1005             


Asn Phe  Thr Gly Cys Leu Gly  Arg Val Ala Leu Gly  Gly Leu Pro 
    1010                 1015                 1020             


Leu Pro  Leu Ala Arg Pro Arg  Pro Gly Ala Ala Pro  Gly Ala Arg 
    1025                 1030                 1035             


Glu His  Phe Ala Ser Trp Pro  Gly Thr Pro Ala Pro  Ile Leu Gly 
    1040                 1045                 1050             


Cys Arg  Gly Ala Pro Val Cys  Ala Pro Ser Pro Cys  Leu His Asp 
    1055                 1060                 1065             


Gly Ala  Cys Arg Asp Leu Phe  Asp Ala Phe Ala Cys  Ala Cys Gly 
    1070                 1075                 1080             


Pro Gly  Trp Glu Gly Pro Arg  Cys Glu Ala His Val  Asp Pro Cys 
    1085                 1090                 1095             


His Ser  Ala Pro Cys Ala Arg  Gly Arg Cys His Thr  His Pro Asp 
    1100                 1105                 1110             


Gly Arg  Phe Glu Cys Arg Cys  Pro Pro Gly Phe Gly  Gly Pro Arg 
    1115                 1120                 1125             


Cys Arg  Leu Pro Val Pro Ser  Lys Glu Cys Ser Leu  Asn Val Thr 
    1130                 1135                 1140             


Cys Leu  Asp Gly Ser Pro Cys  Glu Gly Gly Ser Pro  Ala Ala Asn 
    1145                 1150                 1155             


Cys Ser  Cys Leu Glu Gly Leu  Ala Gly Gln Arg Cys  Gln Val Pro 
    1160                 1165                 1170             


Thr Leu  Pro Cys Glu Ala Asn  Pro Cys Leu Asn Gly  Gly Thr Cys 
    1175                 1180                 1185             


Arg Ala  Ala Gly Gly Val Ser  Glu Cys Ile Cys Asn  Ala Arg Phe 
    1190                 1195                 1200             


Ser Gly  Gln Phe Cys Glu Val  Ala Lys Gly Leu Pro  Leu Pro Leu 
    1205                 1210                 1215             


Pro Phe  Pro Leu Leu Glu Val  Ala Val Pro Ala Ala  Cys Ala Cys 
    1220                 1225                 1230             


Leu Leu  Leu Leu Leu Leu Gly  Leu Leu Ser Gly Ile  Leu Ala Ala 
    1235                 1240                 1245             


Arg Lys  Arg Arg Gln Ser Glu  Gly Thr Tyr Ser Pro  Ser Gln Gln 
    1250                 1255                 1260             


Glu Val  Ala Gly Ala Arg Leu  Glu Met Asp Ser Val  Leu Lys Val 
    1265                 1270                 1275             


Pro Pro  Glu Glu Arg Leu Ile  
    1280                 1285 


<210>  2560
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRB3__Homo_sapiens__NP_777377

<400>  2560

Met Ala Asn Pro Gly Leu Gly Leu Leu Leu Ala Leu Gly Leu Pro Phe 
1               5                   10                  15      


Leu Leu Ala Arg Trp Gly Arg Ala Trp Gly Gln Ile Gln Thr Thr Ser 
            20                  25                  30          


Ala Asn Glu Asn Ser Thr Val Leu Pro Ser Ser Thr Ser Ser Ser Ser 
        35                  40                  45              


Asp Gly Asn Leu Arg Pro Glu Ala Ile Thr Ala Ile Ile Val Val Phe 
    50                  55                  60                  


Ser Leu Leu Ala Ala Leu Leu Leu Ala Val Gly Leu Ala Leu Leu Val 
65                  70                  75                  80  


Arg Lys Leu Arg Glu Lys Arg Gln Thr Glu Gly Thr Tyr Arg Pro Ser 
                85                  90                  95      


Ser Glu Glu Gln Phe Ser His Ala Ala Glu Ala Arg Ala Pro Gln Asp 
            100                 105                 110         


Ser Lys Glu Thr Val Gln Gly Cys Leu Pro Ile 
        115                 120             


<210>  2561
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRBN__Homo_sapiens__NP_001166953

<400>  2561

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Glu Ser Glu Glu Glu Asp Glu Met Glu Val 
            20                  25                  30          


Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn Phe 
        35                  40                  45              


Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu 
    50                  55                  60                  


Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val Ile 
65                  70                  75                  80  


Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr Leu 
                85                  90                  95      


Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn Leu 
            100                 105                 110         


Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gln 
        115                 120                 125             


Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr Arg 
    130                 135                 140                 


Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile Gly 
145                 150                 155                 160 


Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly Ile 
                165                 170                 175     


Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr 
            180                 185                 190         


Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro 
        195                 200                 205             


Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln 
    210                 215                 220                 


Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro 
225                 230                 235                 240 


Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile 
                245                 250                 255     


Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu 
            260                 265                 270         


Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro 
        275                 280                 285             


Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile 
    290                 295                 300                 


Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu 
305                 310                 315                 320 


Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile 
                325                 330                 335     


Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His 
            340                 345                 350         


Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn 
        355                 360                 365             


Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala 
    370                 375                 380                 


Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys 
385                 390                 395                 400 


Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu 
                405                 410                 415     


Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile 
            420                 425                 430         


Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440     


<210>  2562
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRCP__Homo_sapiens__NP_001035737

<400>  2562

Met Glu Val Lys Asp Ala Asn Ser Ala Leu Leu Ser Asn Tyr Glu Thr 
1               5                   10                  15      


Leu Lys Tyr Ile Ser Lys Thr Pro Cys Arg His Gln Ser Pro Glu Ile 
            20                  25                  30          


Val Arg Glu Phe Leu Thr Ala Leu Lys Ser His Lys Leu Thr Lys Ala 
        35                  40                  45              


Glu Lys Leu Gln Leu Leu Asn His Arg Pro Val Thr Ala Val Glu Ile 
    50                  55                  60                  


Gln Leu Met Val Glu Glu Ser Glu Glu Arg Leu Thr Glu Glu Gln Ile 
65                  70                  75                  80  


Glu Ala Leu Leu His Thr Val Thr Ser Ile Leu Pro Ala Glu Pro Glu 
                85                  90                  95      


Ala Glu Gln Lys Lys Asn Thr Asn Ser Asn Val Ala Met Asp Glu Glu 
            100                 105                 110         


Asp Pro Ala 
        115 


<210>  2563
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRCT1__Homo_sapiens__NP_061933

<400>  2563

Met Ser Ser Gln Gln Ser Ala Val Ser Ala Lys Gly Phe Ser Lys Gly 
1               5                   10                  15      


Ser Ser Gln Gly Pro Ala Pro Cys Pro Ala Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ser Ser Ser Ser Cys Cys Gly Ser Gly Arg Gly Cys Cys Gly 
        35                  40                  45              


Asp Ser Gly Cys Cys Gly Ser Ser Ser Thr Ser Cys Cys Cys Phe Pro 
    50                  55                  60                  


Arg Arg Arg Arg Arg Gln Arg Ser Ser Gly Cys Cys Cys Cys Gly Gly 
65                  70                  75                  80  


Gly Ser Gln Arg Ser Gln Arg Ser Asn Asn Arg Ser Ser Gly Cys Cys 
                85                  90                  95      


Ser Gly Cys 
            


<210>  2564
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREB1__Homo_sapiens__XP_011508947

<400>  2564

Met Thr Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Thr Glu Ala Glu Asn Gln Gln Met Thr Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Thr Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Thr Ser 
        35                  40                  45              


Ser Ala Pro Thr Val Thr Leu Val Gln Leu Pro Asn Gly Gln Thr Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Thr Val Gln Ser Ser Cys Lys Asp Leu Lys Arg Leu 
                85                  90                  95      


Phe Ser Gly Thr Gln Ile Ser Thr Ile Ala Glu Ser Glu Asp Ser Gln 
            100                 105                 110         


Glu Ser Val Asp Ser Val Thr Asp Ser Gln Lys Arg Arg Glu Ile Leu 
        115                 120                 125             


Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp 
    130                 135                 140                 


Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu Glu Thr 
145                 150                 155                 160 


Ser Ala Pro Ala Ile Thr Thr Val Thr Val Pro Thr Pro Ile Tyr Gln 
                165                 170                 175     


Thr Ser Ser Gly Gln Tyr Ile Ala Ile Thr Gln Gly Gly Ala Ile Gln 
            180                 185                 190         


Leu Ala Asn Asn Gly Thr Asp Gly Val Gln Gly Leu Gln Thr Leu Thr 
        195                 200                 205             


Met Thr Asn Ala Ala Ala Thr Gln Pro Gly Thr Thr Ile Leu Gln Tyr 
    210                 215                 220                 


Ala Gln Thr Thr Asp Gly Gln Gln Ile Leu Val Pro Ser Asn Gln Val 
225                 230                 235                 240 


Val Val Gln Ala Ala Ser Gly Asp Val Gln Thr Tyr Gln Ile Arg Thr 
                245                 250                 255     


Ala Pro Thr Ser Thr Ile Ala Pro Gly Val Val Met Ala Ser Ser Pro 
            260                 265                 270         


Ala Leu Pro Thr Gln Pro Ala Glu Glu Ala Ala Arg Lys Arg Glu Val 
        275                 280                 285             


Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys 
    290                 295                 300                 


Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn 
305                 310                 315                 320 


Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr 
                325                 330                 335     


Cys His Lys Ser Asp 
            340     


<210>  2565
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREB3__Homo_sapiens__NP_006359

<400>  2565

Met Glu Leu Glu Leu Asp Ala Gly Asp Gln Asp Leu Leu Ala Phe Leu 
1               5                   10                  15      


Leu Glu Glu Ser Gly Asp Leu Gly Thr Ala Pro Asp Glu Ala Val Arg 
            20                  25                  30          


Ala Pro Leu Asp Trp Ala Leu Pro Leu Ser Glu Val Pro Ser Asp Trp 
        35                  40                  45              


Glu Val Asp Asp Leu Leu Cys Ser Leu Leu Ser Pro Pro Ala Ser Leu 
    50                  55                  60                  


Asn Ile Leu Ser Ser Ser Asn Pro Cys Leu Val His His Asp His Thr 
65                  70                  75                  80  


Tyr Ser Leu Pro Arg Glu Thr Val Ser Met Asp Leu Glu Ser Glu Ser 
                85                  90                  95      


Cys Arg Lys Glu Gly Thr Gln Met Thr Pro Gln His Met Glu Glu Leu 
            100                 105                 110         


Ala Glu Gln Glu Ile Ala Arg Leu Val Leu Thr Asp Glu Glu Lys Ser 
        115                 120                 125             


Leu Leu Glu Lys Glu Gly Leu Ile Leu Pro Glu Thr Leu Pro Leu Thr 
    130                 135                 140                 


Lys Thr Glu Glu Gln Ile Leu Lys Arg Val Arg Arg Lys Ile Arg Asn 
145                 150                 155                 160 


Lys Arg Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Val Tyr Val Gly 
                165                 170                 175     


Gly Leu Glu Ser Arg Val Leu Lys Tyr Thr Ala Gln Asn Met Glu Leu 
            180                 185                 190         


Gln Asn Lys Val Gln Leu Leu Glu Glu Gln Asn Leu Ser Leu Leu Asp 
        195                 200                 205             


Gln Leu Arg Lys Leu Gln Ala Met Val Ile Glu Ile Ser Asn Lys Thr 
    210                 215                 220                 


Ser Ser Ser Ser Thr Cys Ile Leu Val Leu Leu Val Ser Phe Cys Leu 
225                 230                 235                 240 


Leu Leu Val Pro Ala Met Tyr Ser Ser Asp Thr Arg Gly Ser Leu Pro 
                245                 250                 255     


Ala Glu His Gly Val Leu Ser Arg Gln Leu Arg Ala Leu Pro Ser Glu 
            260                 265                 270         


Asp Pro Tyr Gln Leu Glu Leu Pro Ala Leu Gln Ser Glu Val Pro Lys 
        275                 280                 285             


Asp Ser Thr His Gln Trp Leu Asp Gly Ser Asp Cys Val Leu Gln Ala 
    290                 295                 300                 


Pro Gly Asn Thr Ser Cys Leu Leu His Tyr Met Pro Gln Ala Pro Ser 
305                 310                 315                 320 


Ala Glu Pro Pro Leu Glu Trp Pro Phe Pro Asp Leu Phe Ser Glu Pro 
                325                 330                 335     


Leu Cys Arg Gly Pro Ile Leu Pro Leu Gln Ala Asn Leu Thr Arg Lys 
            340                 345                 350         


Gly Gly Trp Leu Pro Thr Gly Ser Pro Ser Val Ile Leu Gln Asp Arg 
        355                 360                 365             


Tyr Ser Gly 
    370     


<210>  2566
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREB3L1__Homo_sapiens__NP_443086

<400>  2566

Met Asp Ala Val Leu Glu Pro Phe Pro Ala Asp Arg Leu Phe Pro Gly 
1               5                   10                  15      


Ser Ser Phe Leu Asp Leu Gly Asp Leu Asn Glu Ser Asp Phe Leu Asn 
            20                  25                  30          


Asn Ala His Phe Pro Glu His Leu Asp His Phe Thr Glu Asn Met Glu 
        35                  40                  45              


Asp Phe Ser Asn Asp Leu Phe Ser Ser Phe Phe Asp Asp Pro Val Leu 
    50                  55                  60                  


Asp Glu Lys Ser Pro Leu Leu Asp Met Glu Leu Asp Ser Pro Thr Pro 
65                  70                  75                  80  


Gly Ile Gln Ala Glu His Ser Tyr Ser Leu Ser Gly Asp Ser Ala Pro 
                85                  90                  95      


Gln Ser Pro Leu Val Pro Ile Lys Met Glu Asp Thr Thr Gln Asp Ala 
            100                 105                 110         


Glu His Gly Ala Trp Ala Leu Gly His Lys Leu Cys Ser Ile Met Val 
        115                 120                 125             


Lys Gln Glu Gln Ser Pro Glu Leu Pro Val Asp Pro Leu Ala Ala Pro 
    130                 135                 140                 


Ser Ala Met Ala Ala Ala Ala Ala Met Ala Thr Thr Pro Leu Leu Gly 
145                 150                 155                 160 


Leu Ser Pro Leu Ser Arg Leu Pro Ile Pro His Gln Ala Pro Gly Glu 
                165                 170                 175     


Met Thr Gln Leu Pro Val Ile Lys Ala Glu Pro Leu Glu Val Asn Gln 
            180                 185                 190         


Phe Leu Lys Val Thr Pro Glu Asp Leu Val Gln Met Pro Pro Thr Pro 
        195                 200                 205             


Pro Ser Ser His Gly Ser Asp Ser Asp Gly Ser Gln Ser Pro Arg Ser 
    210                 215                 220                 


Leu Pro Pro Ser Ser Pro Val Arg Pro Met Ala Arg Ser Ser Thr Ala 
225                 230                 235                 240 


Ile Ser Thr Ser Pro Leu Leu Thr Ala Pro His Lys Leu Gln Gly Thr 
                245                 250                 255     


Ser Gly Pro Leu Leu Leu Thr Glu Glu Glu Lys Arg Thr Leu Ile Ala 
            260                 265                 270         


Glu Gly Tyr Pro Ile Pro Thr Lys Leu Pro Leu Thr Lys Ala Glu Glu 
        275                 280                 285             


Lys Ala Leu Lys Arg Val Arg Arg Lys Ile Lys Asn Lys Ile Ser Ala 
    290                 295                 300                 


Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Val Glu Cys Leu Glu Lys 
305                 310                 315                 320 


Lys Val Glu Thr Phe Thr Ser Glu Asn Asn Glu Leu Trp Lys Lys Val 
                325                 330                 335     


Glu Thr Leu Glu Asn Ala Asn Arg Thr Leu Leu Gln Gln Leu Gln Lys 
            340                 345                 350         


Leu Gln Thr Leu Val Thr Asn Lys Ile Ser Arg Pro Tyr Lys Met Ala 
        355                 360                 365             


Ala Thr Gln Thr Gly Thr Cys Leu Met Val Ala Ala Leu Cys Phe Val 
    370                 375                 380                 


Leu Val Leu Gly Ser Leu Val Pro Cys Leu Pro Glu Phe Ser Ser Gly 
385                 390                 395                 400 


Ser Gln Thr Val Lys Glu Asp Pro Leu Ala Ala Asp Gly Val Tyr Thr 
                405                 410                 415     


Ala Ser Gln Met Pro Ser Arg Ser Leu Leu Phe Tyr Asp Asp Gly Ala 
            420                 425                 430         


Gly Leu Trp Glu Asp Gly Arg Ser Thr Leu Leu Pro Met Glu Pro Pro 
        435                 440                 445             


Asp Gly Trp Glu Ile Asn Pro Gly Gly Pro Ala Glu Gln Arg Pro Arg 
    450                 455                 460                 


Asp His Leu Gln His Asp His Leu Asp Ser Thr His Glu Thr Thr Lys 
465                 470                 475                 480 


Tyr Leu Ser Glu Ala Trp Pro Lys Asp Gly Gly Asn Gly Thr Ser Pro 
                485                 490                 495     


Asp Phe Ser His Ser Lys Glu Trp Phe His Asp Arg Asp Leu Gly Pro 
            500                 505                 510         


Asn Thr Thr Ile Lys Leu Ser 
        515                 


<210>  2567
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREB3L2__Homo_sapiens__NP_001240704

<400>  2567

Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg 
1               5                   10                  15      


Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr 
            20                  25                  30          


His Thr His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu 
        35                  40                  45              


Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met 
    50                  55                  60                  


Glu Val Glu Pro Ser Pro Thr Ser Pro Ala Pro Leu Ile Gln Ala Glu 
65                  70                  75                  80  


His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Thr 
                85                  90                  95      


His Ile Thr Thr Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu 
            100                 105                 110         


Lys Trp Tyr Leu Ser Thr Asp Phe Pro Ser Thr Ser Ile Lys Thr Glu 
        115                 120                 125             


Pro Val Thr Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Thr Leu 
    130                 135                 140                 


Thr Ile Thr Ala Ile Ser Thr Pro Leu Glu Lys Glu Glu Pro Pro Leu 
145                 150                 155                 160 


Glu Met Asn Thr Gly Val Asp Ser Ser Cys Gln Thr Ile Ile Pro Lys 
                165                 170                 175     


Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro 
            180                 185                 190         


Lys Glu Gly Leu Ser Ala Leu Pro Val Ser Leu Trp Val Met Asp Met 
        195                 200                 205             


Val Ser Gly Ser Thr Glu Arg Glu Tyr Gly Glu Arg Ala Gly Met Ser 
    210                 215                 220                 


Leu Tyr His Arg Cys Cys Ser Trp Leu Tyr Glu Ile Ala Leu Phe Leu 
225                 230                 235                 240 


Lys Asn Lys Asn Phe Ala Ser Lys 
                245             


<210>  2568
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREB3L3__Homo_sapiens__NP_001258924

<400>  2568

Met Asn Thr Asp Leu Ala Ala Gly Lys Met Ala Ser Ala Ala Cys Ser 
1               5                   10                  15      


Met Asp Pro Ile Asp Ser Phe Glu Leu Leu Asp Leu Leu Phe Asp Arg 
            20                  25                  30          


Gln Asp Gly Ile Leu Arg His Val Glu Leu Gly Glu Gly Trp Gly His 
        35                  40                  45              


Val Lys Asp Gln Val Leu Pro Asn Pro Asp Ser Asp Asp Phe Leu Ser 
    50                  55                  60                  


Ser Ile Leu Gly Ser Gly Asp Ser Leu Pro Ser Ser Pro Leu Trp Ser 
65                  70                  75                  80  


Pro Glu Gly Ser Asp Ser Gly Ile Ser Glu Asp Leu Pro Ser Asp Pro 
                85                  90                  95      


Gln Asp Thr Pro Pro Arg Ser Gly Pro Ala Thr Ser Pro Ala Gly Cys 
            100                 105                 110         


His Pro Ala Gln Pro Gly Lys Gly Pro Cys Leu Ser Tyr His Pro Gly 
        115                 120                 125             


Asn Ser Cys Ser Thr Thr Thr Pro Gly Pro Val Ile Gln Val Pro Glu 
    130                 135                 140                 


Ala Ser Val Thr Ile Asp Leu Glu Met Trp Ser Pro Gly Gly Arg Ile 
145                 150                 155                 160 


Cys Ala Glu Lys Pro Ala Asp Pro Val Asp Leu Ser Pro Arg Cys Asn 
                165                 170                 175     


Leu Thr Val Lys Asp Leu Leu Leu Ser Gly Ser Ser Gly Asp Leu Gln 
            180                 185                 190         


Gln His His Leu Gly Ala Ser Tyr Leu Leu Arg Pro Gly Ala Gly His 
        195                 200                 205             


Cys Gln Glu Leu Val Leu Thr Glu Asp Glu Lys Lys Leu Leu Ala Lys 
    210                 215                 220                 


Glu Gly Ile Thr Leu Pro Thr Gln Leu Pro Leu Thr Lys Tyr Glu Glu 
225                 230                 235                 240 


Arg Val Leu Lys Lys Ile Arg Arg Lys Ile Arg Asn Lys Gln Ser Ala 
                245                 250                 255     


Gln Glu Ser Arg Lys Lys Lys Lys Glu Tyr Ile Asp Gly Leu Glu Thr 
            260                 265                 270         


Arg Met Ser Ala Cys Thr Ala Gln Asn Gln Glu Leu Gln Arg Lys Val 
        275                 280                 285             


Leu His Leu Glu Lys Gln Asn Leu Ser Leu Leu Glu Gln Leu Lys Lys 
    290                 295                 300                 


Leu Gln Ala Ile Val Val Gln Ser Thr Ser Lys Ser Ala Gln Thr Gly 
305                 310                 315                 320 


Thr Cys Val Ala Val Leu Leu Leu Ser Phe Ala Leu Ile Ile Leu Pro 
                325                 330                 335     


Ser Ile Ser Pro Phe Gly Pro Asn Lys Thr Glu Ser Pro Gly Asp Phe 
            340                 345                 350         


Ala Pro Val Arg Val Phe Ser Arg Thr Leu His Asn Asp Ala Ala Ser 
        355                 360                 365             


Arg Val Ala Ala Asp Ala Val Pro Gly Ser Glu Ala Pro Gly Pro Arg 
    370                 375                 380                 


Pro Glu Ala Asp Thr Thr Arg Glu Glu Ser Pro Gly Ser Pro Gly Ala 
385                 390                 395                 400 


Asp Trp Gly Phe Gln Asp Thr Ala Asn Leu Thr Asn Ser Thr Glu Glu 
                405                 410                 415     


Leu Asp Asn Ala Thr Leu Val Leu Arg Asn Ala Thr Glu Gly Leu Gly 
            420                 425                 430         


Gln Val Ala Leu Leu Asp Trp Val Ala Pro Gly Pro Ser Thr Gly Ser 
        435                 440                 445             


Gly Arg Ala Gly Leu Glu Ala Ala Gly Asp Glu Leu 
    450                 455                 460 


<210>  2569
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREB3L4__Homo_sapiens__NP_001242908

<400>  2569

Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 


<210>  2570
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREB5__Homo_sapiens__NP_001011666

<400>  2570

Met Phe Cys Thr Ser Gly Gly Asn Ser Ala Ser Val Met Ser Met Arg 
1               5                   10                  15      


Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu His Asn Arg Gln 
            20                  25                  30          


Arg Gln Pro Met Pro Ala Ser Met Pro Gly Thr Leu Pro Asn Pro Thr 
        35                  40                  45              


Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu Arg Gln Met Ser 
    50                  55                  60                  


Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro 
65                  70                  75                  80  


Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu Ala Lys Met Arg 
                85                  90                  95      


Leu Lys Ala Ala Leu Thr His His Pro Ala Ala Met Ser Asn Gly Asn 
            100                 105                 110         


Met Asn Thr Met Gly His Met Met Glu Met Met Gly Ser Arg Gln Asp 
        115                 120                 125             


Gln Thr Pro His His His Met His Ser His Pro His Gln His Gln Thr 
    130                 135                 140                 


Leu Pro Pro His His Pro Tyr Pro His Gln His Gln His Pro Ala His 
145                 150                 155                 160 


His Pro His Pro Gln Pro His His Gln Gln Asn His Pro His His His 
                165                 170                 175     


Ser His Ser His Leu His Ala His Pro Ala His His Gln Thr Ser Pro 
            180                 185                 190         


His Pro Pro Leu His Thr Gly Asn Gln Ala Gln Val Ser Pro Ala Thr 
        195                 200                 205             


Gln Gln Met Gln Pro Thr Gln Thr Ile Gln Pro Pro Gln Pro Thr Gly 
    210                 215                 220                 


Gly Arg Arg Arg Arg Val Val Asp Glu Asp Pro Asp Glu Arg Arg Arg 
225                 230                 235                 240 


Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Thr Arg Cys Arg Gln Lys 
                245                 250                 255     


Arg Lys Val Trp Val Met Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr 
            260                 265                 270         


Gln Thr Asn Met Gln Leu Gln Asn Glu Val Ser Met Leu Lys Asn Glu 
        275                 280                 285             


Val Ala Gln Leu Lys Gln Leu Leu Leu Thr His Lys Asp Cys Pro Ile 
    290                 295                 300                 


Thr Ala Met Gln Lys Glu Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser 
305                 310                 315                 320 


Pro Pro Ala Ser Pro Val Pro Ala Cys Ser Gln Gln Gln Val Ile Gln 
                325                 330                 335     


His Asn Thr Ile Thr Thr Ser Ser Ser Val Ser Glu Val Val Gly Ser 
            340                 345                 350         


Ser Thr Leu Ser Gln Leu Thr Thr His Arg Thr Asp Leu Asn Pro Ile 
        355                 360                 365             


Leu 
    


<210>  2571
<211>  2404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREBBP__Homo_sapiens__NP_001073315

<400>  2571

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Ala Ile Leu Gly Ser Pro Ala Ser Gly Ile Gln 
                405                 410                 415     


Asn Thr Ile Gly Ser Val Gly Thr Gly Gln Gln Asn Ala Thr Ser Leu 
            420                 425                 430         


Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser Met Gln Arg Ala Tyr Ala 
        435                 440                 445             


Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro Gln Thr Gln Leu Gln Pro 
    450                 455                 460                 


Gln Val Pro Gly Gln Gln Pro Ala Gln Pro Gln Thr His Gln Gln Met 
465                 470                 475                 480 


Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro Met Asn Ile Pro Ala Gly 
                485                 490                 495     


Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn Leu Ile Ser Glu Ser Ala 
            500                 505                 510         


Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro Leu Met Asn Asp Gly Ser 
        515                 520                 525             


Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr Ile Pro Thr Ala Ala Pro 
    530                 535                 540                 


Pro Ser Ser Thr Gly Val Arg Lys Gly Trp His Glu His Val Thr Gln 
545                 550                 555                 560 


Asp Leu Arg Ser His Leu Val His Lys Leu Val Gln Ala Ile Phe Pro 
                565                 570                 575     


Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu Val 
            580                 585                 590         


Ala Tyr Ala Lys Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn Ser 
        595                 600                 605             


Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile Gln 
    610                 615                 620                 


Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg Leu His Lys Gln Gly Ile 
625                 630                 635                 640 


Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro Gly Ala Gln Pro Pro Val 
                645                 650                 655     


Ile Pro Gln Ala Gln Pro Val Arg Pro Pro Asn Gly Pro Leu Ser Leu 
            660                 665                 670         


Pro Val Asn Arg Met Gln Val Ser Gln Gly Met Asn Ser Phe Asn Pro 
        675                 680                 685             


Met Ser Leu Gly Asn Val Gln Leu Pro Gln Ala Pro Met Gly Pro Arg 
    690                 695                 700                 


Ala Ala Ser Pro Met Asn His Ser Val Gln Met Asn Ser Met Gly Ser 
705                 710                 715                 720 


Val Pro Gly Met Ala Ile Ser Pro Ser Arg Met Pro Gln Pro Pro Asn 
                725                 730                 735     


Met Met Gly Ala His Thr Asn Asn Met Met Ala Gln Ala Pro Ala Gln 
            740                 745                 750         


Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro Ser Ser Ser Gly Ala Met 
        755                 760                 765             


Ser Val Gly Met Gly Gln Pro Pro Ala Gln Thr Gly Val Ser Gln Gly 
    770                 775                 780                 


Gln Val Pro Gly Ala Ala Leu Pro Asn Pro Leu Asn Met Leu Gly Pro 
785                 790                 795                 800 


Gln Ala Ser Gln Leu Pro Cys Pro Pro Val Thr Gln Ser Pro Leu His 
                805                 810                 815     


Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala Gly Met Pro Ser Leu Gln 
            820                 825                 830         


His Thr Thr Pro Pro Gly Met Thr Pro Pro Gln Pro Ala Ala Pro Thr 
        835                 840                 845             


Gln Pro Ser Thr Pro Val Ser Ser Ser Gly Gln Thr Pro Thr Pro Thr 
    850                 855                 860                 


Pro Gly Ser Val Pro Ser Ala Thr Gln Thr Gln Ser Thr Pro Thr Val 
865                 870                 875                 880 


Gln Ala Ala Ala Gln Ala Gln Val Thr Pro Gln Pro Gln Thr Pro Val 
                885                 890                 895     


Gln Pro Pro Ser Val Ala Thr Pro Gln Ser Ser Gln Gln Gln Pro Thr 
            900                 905                 910         


Pro Val His Ala Gln Pro Pro Gly Thr Pro Leu Ser Gln Ala Ala Ala 
        915                 920                 925             


Ser Ile Asp Asn Arg Val Pro Thr Pro Ser Ser Val Ala Ser Ala Glu 
    930                 935                 940                 


Thr Asn Ser Gln Gln Pro Gly Pro Asp Val Pro Val Leu Glu Met Lys 
945                 950                 955                 960 


Thr Glu Thr Gln Ala Glu Asp Thr Glu Pro Asp Pro Gly Glu Ser Lys 
                965                 970                 975     


Gly Glu Pro Arg Ser Glu Met Met Glu Glu Asp Leu Gln Gly Ala Ser 
            980                 985                 990         


Gln Val Lys Glu Glu Thr Asp Ile  Ala Glu Gln Lys Ser  Glu Pro Met 
        995                 1000                 1005             


Glu Val  Asp Glu Lys Lys Pro  Glu Val Lys Val Glu  Val Lys Glu 
    1010                 1015                 1020             


Glu Glu  Glu Ser Ser Ser Asn  Gly Thr Ala Ser Gln  Ser Thr Ser 
    1025                 1030                 1035             


Pro Ser  Gln Pro Arg Lys Lys  Ile Phe Lys Pro Glu  Glu Leu Arg 
    1040                 1045                 1050             


Gln Ala  Leu Met Pro Thr Leu  Glu Ala Leu Tyr Arg  Gln Asp Pro 
    1055                 1060                 1065             


Glu Ser  Leu Pro Phe Arg Gln  Pro Val Asp Pro Gln  Leu Leu Gly 
    1070                 1075                 1080             


Ile Pro  Asp Tyr Phe Asp Ile  Val Lys Asn Pro Met  Asp Leu Ser 
    1085                 1090                 1095             


Thr Ile  Lys Arg Lys Leu Asp  Thr Gly Gln Tyr Gln  Glu Pro Trp 
    1100                 1105                 1110             


Gln Tyr  Val Asp Asp Val Trp  Leu Met Phe Asn Asn  Ala Trp Leu 
    1115                 1120                 1125             


Tyr Asn  Arg Lys Thr Ser Arg  Val Tyr Lys Phe Cys  Ser Lys Leu 
    1130                 1135                 1140             


Ala Glu  Val Phe Glu Gln Glu  Ile Asp Pro Val Met  Gln Ser Leu 
    1145                 1150                 1155             


Gly Tyr  Cys Cys Gly Arg Lys  Tyr Glu Phe Ser Pro  Gln Thr Leu 
    1160                 1165                 1170             


Cys Cys  Tyr Gly Lys Gln Leu  Cys Thr Ile Pro Arg  Asp Ala Ala 
    1175                 1180                 1185             


Tyr Tyr  Ser Tyr Gln Asn Arg  Tyr His Phe Cys Glu  Lys Cys Phe 
    1190                 1195                 1200             


Thr Glu  Ile Gln Gly Glu Asn  Val Thr Leu Gly Asp  Asp Pro Ser 
    1205                 1210                 1215             


Gln Pro  Gln Thr Thr Ile Ser  Lys Asp Gln Phe Glu  Lys Lys Lys 
    1220                 1225                 1230             


Asn Asp  Thr Leu Asp Pro Glu  Pro Phe Val Asp Cys  Lys Glu Cys 
    1235                 1240                 1245             


Gly Arg  Lys Met His Gln Ile  Cys Val Leu His Tyr  Asp Ile Ile 
    1250                 1255                 1260             


Trp Pro  Ser Gly Phe Val Cys  Asp Asn Cys Leu Lys  Lys Thr Gly 
    1265                 1270                 1275             


Arg Pro  Arg Lys Glu Asn Lys  Phe Ser Ala Lys Arg  Leu Gln Thr 
    1280                 1285                 1290             


Thr Arg  Leu Gly Asn His Leu  Glu Asp Arg Val Asn  Lys Phe Leu 
    1295                 1300                 1305             


Arg Arg  Gln Asn His Pro Glu  Ala Gly Glu Val Phe  Val Arg Val 
    1310                 1315                 1320             


Val Ala  Ser Ser Asp Lys Thr  Val Glu Val Lys Pro  Gly Met Lys 
    1325                 1330                 1335             


Ser Arg  Phe Val Asp Ser Gly  Glu Met Ser Glu Ser  Phe Pro Tyr 
    1340                 1345                 1350             


Arg Thr  Lys Ala Leu Phe Ala  Phe Glu Glu Ile Asp  Gly Val Asp 
    1355                 1360                 1365             


Val Cys  Phe Phe Gly Met His  Val Gln Glu Tyr Gly  Ser Asp Cys 
    1370                 1375                 1380             


Pro Pro  Pro Asn Thr Arg Arg  Val Tyr Ile Ser Tyr  Leu Asp Ser 
    1385                 1390                 1395             


Ile His  Phe Phe Arg Pro Arg  Cys Leu Arg Thr Ala  Val Tyr His 
    1400                 1405                 1410             


Glu Ile  Leu Ile Gly Tyr Leu  Glu Tyr Val Lys Lys  Leu Gly Tyr 
    1415                 1420                 1425             


Val Thr  Gly His Ile Trp Ala  Cys Pro Pro Ser Glu  Gly Asp Asp 
    1430                 1435                 1440             


Tyr Ile  Phe His Cys His Pro  Pro Asp Gln Lys Ile  Pro Lys Pro 
    1445                 1450                 1455             


Lys Arg  Leu Gln Glu Trp Tyr  Lys Lys Met Leu Asp  Lys Ala Phe 
    1460                 1465                 1470             


Ala Glu  Arg Ile Ile His Asp  Tyr Lys Asp Ile Phe  Lys Gln Ala 
    1475                 1480                 1485             


Thr Glu  Asp Arg Leu Thr Ser  Ala Lys Glu Leu Pro  Tyr Phe Glu 
    1490                 1495                 1500             


Gly Asp  Phe Trp Pro Asn Val  Leu Glu Glu Ser Ile  Lys Glu Leu 
    1505                 1510                 1515             


Glu Gln  Glu Glu Glu Glu Arg  Lys Lys Glu Glu Ser  Thr Ala Ala 
    1520                 1525                 1530             


Ser Glu  Thr Thr Glu Gly Ser  Gln Gly Asp Ser Lys  Asn Ala Lys 
    1535                 1540                 1545             


Lys Lys  Asn Asn Lys Lys Thr  Asn Lys Asn Lys Ser  Ser Ile Ser 
    1550                 1555                 1560             


Arg Ala  Asn Lys Lys Lys Pro  Ser Met Pro Asn Val  Ser Asn Asp 
    1565                 1570                 1575             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1580                 1585                 1590             


Phe Phe  Val Ile His Leu His  Ala Gly Pro Val Ile  Asn Thr Leu 
    1595                 1600                 1605             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Leu Ser Cys  Asp Leu Met 
    1610                 1615                 1620             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Trp 
    1625                 1630                 1635             


Glu Phe  Ser Ser Leu Arg Arg  Ser Lys Trp Ser Thr  Leu Cys Met 
    1640                 1645                 1650             


Leu Val  Glu Leu His Thr Gln  Gly Gln Asp Arg Phe  Val Tyr Thr 
    1655                 1660                 1665             


Cys Asn  Glu Cys Lys His His  Val Glu Thr Arg Trp  His Cys Thr 
    1670                 1675                 1680             


Val Cys  Glu Asp Tyr Asp Leu  Cys Ile Asn Cys Tyr  Asn Thr Lys 
    1685                 1690                 1695             


Ser His  Ala His Lys Met Val  Lys Trp Gly Leu Gly  Leu Asp Asp 
    1700                 1705                 1710             


Glu Gly  Ser Ser Gln Gly Glu  Pro Gln Ser Lys Ser  Pro Gln Glu 
    1715                 1720                 1725             


Ser Arg  Arg Leu Ser Ile Gln  Arg Cys Ile Gln Ser  Leu Val His 
    1730                 1735                 1740             


Ala Cys  Gln Cys Arg Asn Ala  Asn Cys Ser Leu Pro  Ser Cys Gln 
    1745                 1750                 1755             


Lys Met  Lys Arg Val Val Gln  His Thr Lys Gly Cys  Lys Arg Lys 
    1760                 1765                 1770             


Thr Asn  Gly Gly Cys Pro Val  Cys Lys Gln Leu Ile  Ala Leu Cys 
    1775                 1780                 1785             


Cys Tyr  His Ala Lys His Cys  Gln Glu Asn Lys Cys  Pro Val Pro 
    1790                 1795                 1800             


Phe Cys  Leu Asn Ile Lys His  Lys Leu Arg Gln Gln  Gln Ile Gln 
    1805                 1810                 1815             


His Arg  Leu Gln Gln Ala Gln  Leu Met Arg Arg Arg  Met Ala Thr 
    1820                 1825                 1830             


Met Asn  Thr Arg Asn Val Pro  Gln Gln Ser Leu Pro  Ser Pro Thr 
    1835                 1840                 1845             


Ser Ala  Pro Pro Gly Thr Pro  Thr Gln Gln Pro Ser  Thr Pro Gln 
    1850                 1855                 1860             


Thr Pro  Gln Pro Pro Ala Gln  Pro Gln Pro Ser Pro  Val Ser Met 
    1865                 1870                 1875             


Ser Pro  Ala Gly Phe Pro Ser  Val Ala Arg Thr Gln  Pro Pro Thr 
    1880                 1885                 1890             


Thr Val  Ser Thr Gly Lys Pro  Thr Ser Gln Val Pro  Ala Pro Pro 
    1895                 1900                 1905             


Pro Pro  Ala Gln Pro Pro Pro  Ala Ala Val Glu Ala  Ala Arg Gln 
    1910                 1915                 1920             


Ile Glu  Arg Glu Ala Gln Gln  Gln Gln His Leu Tyr  Arg Val Asn 
    1925                 1930                 1935             


Ile Asn  Asn Ser Met Pro Pro  Gly Arg Thr Gly Met  Gly Thr Pro 
    1940                 1945                 1950             


Gly Ser  Gln Met Ala Pro Val  Ser Leu Asn Val Pro  Arg Pro Asn 
    1955                 1960                 1965             


Gln Val  Ser Gly Pro Val Met  Pro Ser Met Pro Pro  Gly Gln Trp 
    1970                 1975                 1980             


Gln Gln  Ala Pro Leu Pro Gln  Gln Gln Pro Met Pro  Gly Leu Pro 
    1985                 1990                 1995             


Arg Pro  Val Ile Ser Met Gln  Ala Gln Ala Ala Val  Ala Gly Pro 
    2000                 2005                 2010             


Arg Met  Pro Ser Val Gln Pro  Pro Arg Ser Ile Ser  Pro Ser Ala 
    2015                 2020                 2025             


Leu Gln  Asp Leu Leu Arg Thr  Leu Lys Ser Pro Ser  Ser Pro Gln 
    2030                 2035                 2040             


Gln Gln  Gln Gln Val Leu Asn  Ile Leu Lys Ser Asn  Pro Gln Leu 
    2045                 2050                 2055             


Met Ala  Ala Phe Ile Lys Gln  Arg Thr Ala Lys Tyr  Val Ala Asn 
    2060                 2065                 2070             


Gln Pro  Gly Met Gln Pro Gln  Pro Gly Leu Gln Ser  Gln Pro Gly 
    2075                 2080                 2085             


Met Gln  Pro Gln Pro Gly Met  His Gln Gln Pro Ser  Leu Gln Asn 
    2090                 2095                 2100             


Leu Asn  Ala Met Gln Ala Gly  Val Pro Arg Pro Gly  Val Pro Pro 
    2105                 2110                 2115             


Gln Gln  Gln Ala Met Gly Gly  Leu Asn Pro Gln Gly  Gln Ala Leu 
    2120                 2125                 2130             


Asn Ile  Met Asn Pro Gly His  Asn Pro Asn Met Ala  Ser Met Asn 
    2135                 2140                 2145             


Pro Gln  Tyr Arg Glu Met Leu  Arg Arg Gln Leu Leu  Gln Gln Gln 
    2150                 2155                 2160             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2165                 2170                 2175             


Gly Ser  Ala Gly Met Ala Gly  Gly Met Ala Gly His  Gly Gln Phe 
    2180                 2185                 2190             


Gln Gln  Pro Gln Gly Pro Gly  Gly Tyr Pro Pro Ala  Met Gln Gln 
    2195                 2200                 2205             


Gln Gln  Arg Met Gln Gln His  Leu Pro Leu Gln Gly  Ser Ser Met 
    2210                 2215                 2220             


Gly Gln  Met Ala Ala Gln Met  Gly Gln Leu Gly Gln  Met Gly Gln 
    2225                 2230                 2235             


Pro Gly  Leu Gly Ala Asp Ser  Thr Pro Asn Ile Gln  Gln Ala Leu 
    2240                 2245                 2250             


Gln Gln  Arg Ile Leu Gln Gln  Gln Gln Met Lys Gln  Gln Ile Gly 
    2255                 2260                 2265             


Ser Pro  Gly Gln Pro Asn Pro  Met Ser Pro Gln Gln  His Met Leu 
    2270                 2275                 2280             


Ser Gly  Gln Pro Gln Ala Ser  His Leu Pro Gly Gln  Gln Ile Ala 
    2285                 2290                 2295             


Thr Ser  Leu Ser Asn Gln Val  Arg Ser Pro Ala Pro  Val Gln Ser 
    2300                 2305                 2310             


Pro Arg  Pro Gln Ser Gln Pro  Pro His Ser Ser Pro  Ser Pro Arg 
    2315                 2320                 2325             


Ile Gln  Pro Gln Pro Ser Pro  His His Val Ser Pro  Gln Thr Gly 
    2330                 2335                 2340             


Ser Pro  His Pro Gly Leu Ala  Val Thr Met Ala Ser  Ser Ile Asp 
    2345                 2350                 2355             


Gln Gly  His Leu Gly Asn Pro  Glu Gln Ser Ala Met  Leu Pro Gln 
    2360                 2365                 2370             


Leu Asn  Thr Pro Ser Arg Ser  Ala Leu Ser Ser Glu  Leu Ser Leu 
    2375                 2380                 2385             


Val Gly  Asp Thr Thr Gly Asp  Thr Leu Glu Lys Phe  Val Glu Gly 
    2390                 2395                 2400             


Leu 
    


<210>  2572
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREBRF__Homo_sapiens__NP_001161865

<400>  2572

Met Pro Gln Pro Ser Val Ser Gly Met Asp Pro Pro Phe Gly Asp Ala 
1               5                   10                  15      


Phe Arg Ser His Thr Phe Ser Glu Gln Thr Leu Met Ser Thr Asp Leu 
            20                  25                  30          


Leu Ala Asn Ser Ser Asp Pro Asp Phe Met Tyr Glu Leu Asp Arg Glu 
        35                  40                  45              


Met Asn Tyr Gln Gln Asn Pro Arg Asp Asn Phe Leu Ser Leu Glu Asp 
    50                  55                  60                  


Cys Lys Asp Ile Glu Asn Leu Glu Ser Phe Thr Asp Val Leu Asp Asn 
65                  70                  75                  80  


Glu Gly Ala Leu Thr Ser Asn Trp Glu Gln Trp Asp Thr Tyr Cys Glu 
                85                  90                  95      


Asp Leu Thr Lys Tyr Thr Lys Leu Thr Ser Cys Asp Ile Trp Gly Thr 
            100                 105                 110         


Lys Glu Val Asp Tyr Leu Gly Leu Asp Asp Phe Ser Ser Pro Tyr Gln 
        115                 120                 125             


Asp Glu Glu Val Ile Ser Lys Thr Pro Thr Leu Ala Gln Leu Asn Ser 
    130                 135                 140                 


Glu Asp Ser Gln Ser Val Ser Asp Ser Leu Tyr Tyr Pro Asp Ser Leu 
145                 150                 155                 160 


Phe Ser Val Lys Gln Asn Pro Leu Pro Ser Ser Phe Pro Gly Lys Lys 
                165                 170                 175     


Ile Thr Ser Arg Ala Ala Ala Pro Val Cys Ser Ser Lys Thr Leu Gln 
            180                 185                 190         


Ala Glu Val Pro Leu Ser Asp Cys Val Gln Lys Ala Ser Lys Pro Thr 
        195                 200                 205             


Ser Ser Thr Gln Ile Met Val Lys Thr Asn Met Tyr His Asn Glu Lys 
    210                 215                 220                 


Val Asn Phe His Val Glu Cys Lys Asp Tyr Val Lys Lys Ala Lys Val 
225                 230                 235                 240 


Lys Ile Asn Pro Val Gln Gln Ser Arg Pro Leu Leu Ser Gln Ile His 
                245                 250                 255     


Thr Asp Ala Ala Lys Glu Asn Thr Cys Tyr Cys Gly Ala Val Ala Lys 
            260                 265                 270         


Arg Gln Glu Lys Lys Gly Met Glu Pro Leu Gln Gly His Ala Thr Pro 
        275                 280                 285             


Ala Leu Pro Phe Lys Glu Thr Gln Glu Leu Leu Leu Ser Pro Leu Pro 
    290                 295                 300                 


Gln Glu Gly Pro Gly Ser Leu Ala Ala Gly Glu Ser Ser Ser Leu Ser 
305                 310                 315                 320 


Ala Ser Thr Ser Val Ser Asp Ser Ser Gln Lys Lys Glu Glu His Asn 
                325                 330                 335     


Tyr Ser Leu Phe Val Ser Asp Asn Leu Gly Glu Gln Pro Thr Lys Cys 
            340                 345                 350         


Ser Pro Glu Glu Asp Glu Glu Asp Glu Glu Asp Val Asp Asp Glu Asp 
        355                 360                 365             


His Asp Glu Gly Phe Gly Ser Glu His Glu Leu Ser Glu Asn Glu Glu 
    370                 375                 380                 


Glu Glu Glu Glu Glu Glu Asp Tyr Glu Asp Asp Lys Asp Asp Asp Ile 
385                 390                 395                 400 


Ser Asp Thr Phe Ser Glu Pro Gly Ile Ile Met Leu Ala Ser Leu Pro 
                405                 410                 415     


Asp 
    


<210>  2573
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREBZF__Homo_sapiens__NP_001034707

<400>  2573

Met Arg His Ser Leu Thr Lys Leu Leu Ala Ala Ser Gly Ser Asn Ser 
1               5                   10                  15      


Pro Thr Arg Ser Glu Ser Pro Glu Pro Ala Ala Thr Cys Ser Leu Pro 
            20                  25                  30          


Ser Asp Leu Thr Arg Ala Ala Ala Gly Glu Glu Glu Thr Ala Ala Ala 
        35                  40                  45              


Gly Ser Pro Gly Arg Lys Gln Gln Phe Gly Asp Glu Gly Glu Leu Glu 
    50                  55                  60                  


Ala Gly Arg Gly Ser Arg Gly Gly Val Ala Val Arg Ala Pro Ser Pro 
65                  70                  75                  80  


Glu Glu Met Glu Glu Glu Ala Ile Ala Ser Leu Pro Gly Glu Glu Thr 
                85                  90                  95      


Glu Asp Met Asp Phe Leu Ser Gly Leu Glu Leu Ala Asp Leu Leu Asp 
            100                 105                 110         


Pro Arg Gln Pro Asp Trp His Leu Asp Pro Gly Leu Ser Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Ser Ser Gly Gly Gly Ser Asp Ser Gly Gly Leu Trp Arg 
    130                 135                 140                 


Gly Asp Asp Asp Asp Glu Ala Ala Ala Ala Glu Met Gln Arg Phe Ser 
145                 150                 155                 160 


Asp Leu Leu Gln Arg Leu Leu Asn Gly Ile Gly Gly Cys Ser Ser Ser 
                165                 170                 175     


Ser Asp Ser Gly Ser Ala Glu Lys Arg Arg Arg Lys Ser Pro Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ser Gly Asn Asp Asn Asn Gln Ala Ala Thr Lys 
        195                 200                 205             


Ser Pro Arg Lys Ala Ala Ala Ala Ala Ala Arg Leu Asn Arg Leu Lys 
    210                 215                 220                 


Lys Lys Glu Tyr Val Met Gly Leu Glu Ser Arg Val Arg Gly Leu Ala 
225                 230                 235                 240 


Ala Glu Asn Gln Glu Leu Arg Ala Glu Asn Arg Glu Leu Gly Lys Arg 
                245                 250                 255     


Val Gln Ala Leu Gln Glu Glu Ser Arg Tyr Leu Arg Ala Val Leu Ala 
            260                 265                 270         


Asn Glu Thr Gly Leu Ala Arg Leu Leu Ser Arg Leu Ser Gly Val Gly 
        275                 280                 285             


Leu Arg Leu Thr Thr Ser Leu Phe Arg Asp Ser Pro Ala Gly Asp His 
    290                 295                 300                 


Asp Tyr Ala Leu Pro Val Gly Lys Gln Lys Gln Asp Leu Leu Glu Glu 
305                 310                 315                 320 


Asp Asp Ser Ala Gly Gly Val Cys Leu His Val Asp Lys Asp Lys Val 
                325                 330                 335     


Ser Val Glu Phe Cys Ser Ala Cys Ala Arg Lys Ala Ser Ser Ser Leu 
            340                 345                 350         


Lys Met 
        


<210>  2574
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREG1__Homo_sapiens__NP_003842

<400>  2574

Met Ala Gly Leu Ser Arg Gly Ser Ala Arg Ala Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Ala Ser Thr Leu Leu Ala Leu Leu Val Ser Pro Ala Arg Gly Arg 
            20                  25                  30          


Gly Gly Arg Asp His Gly Asp Trp Asp Glu Ala Ser Arg Leu Pro Pro 
        35                  40                  45              


Leu Pro Pro Arg Glu Asp Ala Ala Arg Val Ala Arg Phe Val Thr His 
    50                  55                  60                  


Val Ser Asp Trp Gly Ala Leu Ala Thr Ile Ser Thr Leu Glu Ala Val 
65                  70                  75                  80  


Arg Gly Arg Pro Phe Ala Asp Val Leu Ser Leu Ser Asp Gly Pro Pro 
                85                  90                  95      


Gly Ala Gly Ser Gly Val Pro Tyr Phe Tyr Leu Ser Pro Leu Gln Leu 
            100                 105                 110         


Ser Val Ser Asn Leu Gln Glu Asn Pro Tyr Ala Thr Leu Thr Met Thr 
        115                 120                 125             


Leu Ala Gln Thr Asn Phe Cys Lys Lys His Gly Phe Asp Pro Gln Ser 
    130                 135                 140                 


Pro Leu Cys Val His Ile Met Leu Ser Gly Thr Val Thr Lys Val Asn 
145                 150                 155                 160 


Glu Thr Glu Met Asp Ile Ala Lys His Ser Leu Phe Ile Arg His Pro 
                165                 170                 175     


Glu Met Lys Thr Trp Pro Ser Ser His Asn Trp Phe Phe Ala Lys Leu 
            180                 185                 190         


Asn Ile Thr Asn Ile Trp Val Leu Asp Tyr Phe Gly Gly Pro Lys Ile 
        195                 200                 205             


Val Thr Pro Glu Glu Tyr Tyr Asn Val Thr Val Gln 
    210                 215                 220 


<210>  2575
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRELD1__Homo_sapiens__NP_001026887

<400>  2575

Met Ala Pro Trp Pro Pro Lys Gly Leu Val Pro Ala Val Leu Trp Gly 
1               5                   10                  15      


Leu Ser Leu Phe Leu Asn Leu Pro Gly Pro Ile Trp Leu Gln Pro Ser 
            20                  25                  30          


Pro Pro Pro Gln Ser Ser Pro Pro Pro Gln Pro His Pro Cys His Thr 
        35                  40                  45              


Cys Arg Gly Leu Val Asp Ser Phe Asn Lys Gly Leu Glu Arg Thr Ile 
    50                  55                  60                  


Arg Asp Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Glu Asn Leu 
65                  70                  75                  80  


Ser Lys Tyr Lys Asp Ser Glu Thr Arg Leu Val Glu Val Leu Glu Gly 
                85                  90                  95      


Val Cys Ser Lys Ser Asp Phe Glu Cys His Arg Leu Leu Glu Leu Ser 
            100                 105                 110         


Glu Glu Leu Val Glu Ser Trp Trp Phe His Lys Gln Gln Glu Ala Pro 
        115                 120                 125             


Asp Leu Phe Gln Trp Leu Cys Ser Asp Ser Leu Lys Leu Cys Cys Pro 
    130                 135                 140                 


Ala Gly Thr Phe Gly Pro Ser Cys Leu Pro Cys Pro Gly Gly Thr Glu 
145                 150                 155                 160 


Arg Pro Cys Gly Gly Tyr Gly Gln Cys Glu Gly Glu Gly Thr Arg Gly 
                165                 170                 175     


Gly Ser Gly His Cys Asp Cys Gln Ala Gly Tyr Gly Gly Glu Ala Cys 
            180                 185                 190         


Gly Gln Cys Gly Leu Gly Tyr Phe Glu Ala Glu Arg Asn Ala Ser His 
        195                 200                 205             


Leu Val Cys Ser Ala Cys Phe Gly Pro Cys Ala Arg Cys Ser Gly Pro 
    210                 215                 220                 


Glu Glu Ser Asn Cys Leu Gln Cys Lys Lys Gly Trp Ala Leu His His 
225                 230                 235                 240 


Leu Lys Cys Val Asp Ile Asp Glu Cys Gly Thr Glu Gly Ala Asn Cys 
                245                 250                 255     


Gly Ala Asp Gln Phe Cys Val Asn Thr Glu Gly Ser Tyr Glu Cys Arg 
            260                 265                 270         


Asp Cys Ala Lys Ala Cys Leu Gly Cys Met Gly Ala Gly Pro Gly Arg 
        275                 280                 285             


Cys Lys Lys Cys Ser Pro Gly Tyr Gln Gln Val Gly Ser Lys Cys Leu 
    290                 295                 300                 


Asp Val Asp Glu Cys Glu Thr Glu Val Cys Pro Gly Glu Asn Lys Gln 
305                 310                 315                 320 


Cys Glu Asn Thr Glu Gly Gly Tyr Arg Cys Ile Cys Ala Glu Gly Tyr 
                325                 330                 335     


Lys Gln Met Glu Gly Ile Cys Val Lys Glu Gln Ile Pro Gly Ala Phe 
            340                 345                 350         


Pro Ile Leu Thr Asp Leu Thr Pro Glu Thr Thr Arg Arg Trp Lys Leu 
        355                 360                 365             


Gly Ser His Pro His Ser Thr Tyr Val Lys Met Lys Met Gln Arg Asp 
    370                 375                 380                 


Glu Ala Thr Phe Pro Gly Leu Tyr Gly Lys Gln Val Ala Lys Leu Gly 
385                 390                 395                 400 


Ser Gln Ser Arg Gln Ser Asp Arg Gly Thr Arg Leu Ile His Ser Gln 
                405                 410                 415     


Gln Ala Ser Ser Gln Arg 
            420         


<210>  2576
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRELD2__Homo_sapiens__NP_001128573

<400>  2576

Met Arg Leu Pro Arg Arg Ala Ala Leu Gly Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Pro Glu Ala Ala Lys Lys Pro Thr Pro Cys His 
            20                  25                  30          


Arg Cys Arg Gly Leu Val Asp Lys Phe Asn Gln Gly Met Val Asp Thr 
        35                  40                  45              


Ala Lys Lys Asn Phe Gly Gly Gly Asn Thr Ala Trp Glu Glu Lys Thr 
    50                  55                  60                  


Leu Ser Lys Tyr Glu Ser Ser Glu Ile Arg Leu Leu Glu Ile Leu Glu 
65                  70                  75                  80  


Gly Leu Cys Glu Ser Ser Asp Phe Glu Cys Asn Gln Met Leu Glu Ala 
                85                  90                  95      


Gln Glu Glu His Leu Glu Ala Trp Trp Leu Gln Leu Lys Ser Glu Tyr 
            100                 105                 110         


Pro Asp Leu Phe Glu Trp Phe Cys Val Lys Thr Leu Lys Val Cys Cys 
        115                 120                 125             


Ser Pro Gly Thr Tyr Gly Pro Asp Cys Leu Ala Cys Gln Gly Gly Ser 
    130                 135                 140                 


Gln Arg Pro Cys Ser Gly Asn Gly His Cys Ser Gly Asp Gly Ser Arg 
145                 150                 155                 160 


Gln Gly Asp Gly Ser Cys Arg Cys His Met Gly Tyr Gln Gly Pro Leu 
                165                 170                 175     


Cys Thr Asp Cys Met Asp Gly Tyr Phe Ser Ser Leu Arg Asn Glu Thr 
            180                 185                 190         


His Ser Ile Cys Thr Val Arg Thr Gly Leu Ser Asp Ser Tyr Pro Pro 
        195                 200                 205             


Cys Cys Leu Ser Leu Gly Cys Trp Arg Gly Val Gly His Ala Trp Ile 
    210                 215                 220                 


Arg Gly Arg Asn Thr His Thr Gln Pro Gly Tyr Ser Ser Arg Val Trp 
225                 230                 235                 240 


Ile Ala Ala Phe Ser Pro Ala Cys Asp Glu Ser Cys Lys Thr Cys Ser 
                245                 250                 255     


Gly Leu Thr Asn Arg Asp Cys Gly Glu Cys Glu Val Gly Trp Val Leu 
            260                 265                 270         


Asp Glu Gly Ala Cys Val Asp Val Asp Glu Cys Ala Ala Glu Pro Pro 
        275                 280                 285             


Pro Cys Ser Ala Ala Gln Phe Cys Lys Asn Ala Asn Gly Ser Tyr Thr 
    290                 295                 300                 


Cys Glu Glu Cys Asp Ser Ser Cys Val Gly Cys Thr Gly Glu Gly Pro 
305                 310                 315                 320 


Gly Asn Cys Lys Glu Cys Ile Ser Gly Tyr Ala Arg Glu His Gly Gln 
                325                 330                 335     


Cys Ala Asp Val Asp Glu Cys Ser Leu Ala Glu Lys Thr Cys Val Arg 
            340                 345                 350         


Lys Asn Glu Asn Cys Tyr Asn Thr Pro Gly Ser Tyr Val Cys Val Cys 
        355                 360                 365             


Pro Asp Gly Phe Glu Glu Thr Glu Asp Ala Cys Val Pro Pro Ala Glu 
    370                 375                 380                 


Ala Glu Ala Thr Glu Gly Glu Ser Pro Thr Gln Leu Pro Ser Arg Glu 
385                 390                 395                 400 


Asp Leu 
        


<210>  2577
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CREM__Homo_sapiens__NP_001254491

<400>  2577

Met Ala Val Pro Thr Ser Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile 
1               5                   10                  15      


Ala Ile Ala Gln Gly Gly Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp 
            20                  25                  30          


Gly Val Gln Gly Leu Gln Ala Leu Thr Met Thr Asn Ser Gly Ala Pro 
        35                  40                  45              


Pro Pro Gly Ala Thr Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly 
    50                  55                  60                  


Thr Gln Gln Phe Phe Val Pro Gly Ser Gln Val Val Val Gln Ala Ala 
65                  70                  75                  80  


Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu 
                85                  90                  95      


Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro 
            100                 105                 110         


Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met 
        115                 120                 125             


Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr 
    130                 135                 140                 


Val Lys Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys 
145                 150                 155                 160 


Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys 
                165                 170                 175     


Thr Asp Tyr 
            


<210>  2578
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRHBP__Homo_sapiens__NP_001873

<400>  2578

Met Ser Pro Asn Phe Lys Leu Gln Cys His Phe Ile Leu Ile Phe Leu 
1               5                   10                  15      


Thr Ala Leu Arg Gly Glu Ser Arg Tyr Leu Glu Leu Arg Glu Ala Ala 
            20                  25                  30          


Asp Tyr Asp Pro Phe Leu Leu Phe Ser Ala Asn Leu Lys Arg Glu Leu 
        35                  40                  45              


Ala Gly Glu Gln Pro Tyr Arg Arg Ala Leu Arg Cys Leu Asp Met Leu 
    50                  55                  60                  


Ser Leu Gln Gly Gln Phe Thr Phe Thr Ala Asp Arg Pro Gln Leu His 
65                  70                  75                  80  


Cys Ala Ala Phe Phe Ile Ser Glu Pro Glu Glu Phe Ile Thr Ile His 
                85                  90                  95      


Tyr Asp Gln Val Ser Ile Asp Cys Gln Gly Gly Asp Phe Leu Lys Val 
            100                 105                 110         


Phe Asp Gly Trp Ile Leu Lys Gly Glu Lys Phe Pro Ser Ser Gln Asp 
        115                 120                 125             


His Pro Leu Pro Ser Ala Glu Arg Tyr Ile Asp Phe Cys Glu Ser Gly 
    130                 135                 140                 


Leu Ser Arg Arg Ser Ile Arg Ser Ser Gln Asn Val Ala Met Ile Phe 
145                 150                 155                 160 


Phe Arg Val His Glu Pro Gly Asn Gly Phe Thr Leu Thr Ile Lys Thr 
                165                 170                 175     


Asp Pro Asn Leu Phe Pro Cys Asn Val Ile Ser Gln Thr Pro Asn Gly 
            180                 185                 190         


Lys Phe Thr Leu Val Val Pro His Gln His Arg Asn Cys Ser Phe Ser 
        195                 200                 205             


Ile Ile Tyr Pro Val Val Ile Lys Ile Ser Asp Leu Thr Leu Gly His 
    210                 215                 220                 


Val Asn Gly Leu Gln Leu Lys Lys Ser Ser Ala Gly Cys Glu Gly Ile 
225                 230                 235                 240 


Gly Asp Phe Val Glu Leu Leu Gly Gly Thr Gly Leu Asp Pro Ser Lys 
                245                 250                 255     


Met Thr Pro Leu Ala Asp Leu Cys Tyr Pro Phe His Gly Pro Ala Gln 
            260                 265                 270         


Met Lys Val Gly Cys Asp Asn Thr Val Val Arg Met Val Ser Ser Gly 
        275                 280                 285             


Lys His Val Asn Arg Val Thr Phe Glu Tyr Arg Gln Leu Glu Pro Tyr 
    290                 295                 300                 


Glu Leu Glu Asn Pro Asn Gly Asn Ser Ile Gly Glu Phe Cys Leu Ser 
305                 310                 315                 320 


Gly Leu 
        


<210>  2579
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRH__Homo_sapiens__NP_000747

<400>  2579

Met Arg Leu Pro Leu Leu Val Ser Ala Gly Val Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Pro Cys Pro Pro Cys Arg Ala Leu Leu Ser Arg Gly Pro Val Pro 
            20                  25                  30          


Gly Ala Arg Gln Ala Pro Gln His Pro Gln Pro Leu Asp Phe Phe Gln 
        35                  40                  45              


Pro Pro Pro Gln Ser Glu Gln Pro Gln Gln Pro Gln Ala Arg Pro Val 
    50                  55                  60                  


Leu Leu Arg Met Gly Glu Glu Tyr Phe Leu Arg Leu Gly Asn Leu Asn 
65                  70                  75                  80  


Lys Ser Pro Ala Ala Pro Leu Ser Pro Ala Ser Ser Leu Leu Ala Gly 
                85                  90                  95      


Gly Ser Gly Ser Arg Pro Ser Pro Glu Gln Ala Thr Ala Asn Phe Phe 
            100                 105                 110         


Arg Val Leu Leu Gln Gln Leu Leu Leu Pro Arg Arg Ser Leu Asp Ser 
        115                 120                 125             


Pro Ala Ala Leu Ala Glu Arg Gly Ala Arg Asn Ala Leu Gly Gly His 
    130                 135                 140                 


Gln Glu Ala Pro Glu Arg Glu Arg Arg Ser Glu Glu Pro Pro Ile Ser 
145                 150                 155                 160 


Leu Asp Leu Thr Phe His Leu Leu Arg Glu Val Leu Glu Met Ala Arg 
                165                 170                 175     


Ala Glu Gln Leu Ala Gln Gln Ala His Ser Asn Arg Lys Leu Met Glu 
            180                 185                 190         


Ile Ile Gly Lys 
        195     


<210>  2580
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRHR1__Homo_sapiens__NP_001138618

<400>  2580

Met Gly Gly His Pro Gln Leu Arg Leu Val Lys Ala Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Asn Pro Val Ser Ala Ser Leu Gln Asp Gln His Cys Glu Ser 
            20                  25                  30          


Leu Ser Leu Ala Ser Asn Ile Ser Gly Leu Gln Cys Asn Ala Ser Val 
        35                  40                  45              


Asp Leu Ile Gly Thr Cys Trp Pro Arg Ser Pro Ala Gly Gln Leu Val 
    50                  55                  60                  


Val Arg Pro Cys Pro Ala Phe Phe Tyr Gly Val Arg Tyr Asn Thr Thr 
65                  70                  75                  80  


Asn Asn Gly Tyr Arg Glu Cys Leu Ala Asn Gly Ser Trp Ala Ala Arg 
                85                  90                  95      


Val Asn Tyr Ser Glu Cys Gln Glu Ile Leu Asn Glu Glu Lys Lys Ser 
            100                 105                 110         


Lys Val His Tyr His Val Ala Val Ile Ile Asn Tyr Leu Gly His Cys 
        115                 120                 125             


Ile Ser Leu Val Ala Leu Leu Val Ala Phe Val Leu Phe Leu Arg Leu 
    130                 135                 140                 


Arg Pro Gly Cys Thr His Trp Gly Asp Gln Ala Asp Gly Ala Leu Glu 
145                 150                 155                 160 


Val Gly Ala Pro Trp Ser Gly Ala Pro Phe Gln Val Arg Arg Ser Ile 
                165                 170                 175     


Arg Cys Leu Arg Asn Ile Ile His Trp Asn Leu Ile Ser Ala Phe Ile 
            180                 185                 190         


Leu Arg Asn Ala Thr Trp Phe Val Val Gln Leu Thr Met Ser Pro Glu 
        195                 200                 205             


Val His Gln Ser Asn Val Gly Trp Cys Arg Leu Val Thr Ala Ala Tyr 
    210                 215                 220                 


Asn Tyr Phe His Val Thr Asn Phe Phe Trp Met Phe Gly Glu Gly Cys 
225                 230                 235                 240 


Tyr Leu His Thr Ala Ile Val Leu Thr Tyr Ser Thr Asp Arg Leu Arg 
                245                 250                 255     


Lys Trp Met Phe Ile Cys Ile Gly Trp Gly Val Pro Phe Pro Ile Ile 
            260                 265                 270         


Val Ala Trp Ala Ile Gly Lys Leu Tyr Tyr Asp Asn Glu Lys Cys Trp 
        275                 280                 285             


Phe Gly Lys Arg Pro Gly Val Tyr Thr Asp Tyr Ile Tyr Gln Gly Pro 
    290                 295                 300                 


Met Ile Leu Val Leu Leu Ile Asn Phe Ile Phe Leu Phe Asn Ile Val 
305                 310                 315                 320 


Arg Ile Leu Met Thr Lys Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile 
                325                 330                 335     


Gln Tyr Arg Lys Ala Val Lys Ala Thr Leu Val Leu Leu Pro Leu Leu 
            340                 345                 350         


Gly Ile Thr Tyr Met Leu Phe Phe Val Asn Pro Gly Glu Asp Glu Val 
        355                 360                 365             


Ser Arg Val Val Phe Ile Tyr Phe Asn Ser Phe Leu Glu Ser Phe Gln 
    370                 375                 380                 


Gly Phe Phe Val Ser Val Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg 
385                 390                 395                 400 


Ser Ala Ile Arg Lys Arg Trp His Arg Trp Gln Asp Lys His Ser Ile 
                405                 410                 415     


Arg Ala Arg Val Ala Arg Ala Met Ser Ile Pro Thr Ser Pro Thr Arg 
            420                 425                 430         


Val Ser Phe His Ser Ile Lys Gln Ser Thr Ala Val 
        435                 440                 


<210>  2581
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRHR2__Homo_sapiens__NP_001189404

<400>  2581

Met Arg Gly Pro Ser Gly Pro Pro Gly Leu Leu Tyr Val Pro His Leu 
1               5                   10                  15      


Leu Leu Cys Leu Leu Cys Leu Leu Pro Pro Pro Leu Gln Tyr Ala Ala 
            20                  25                  30          


Gly Gln Ser Gln Met Pro Lys Asp Gln Pro Leu Trp Ala Leu Leu Glu 
        35                  40                  45              


Gln Tyr Cys His Thr Ile Met Thr Leu Thr Asn Leu Ser Gly Pro Tyr 
    50                  55                  60                  


Ser Tyr Cys Asn Thr Thr Leu Asp Gln Ile Gly Thr Cys Trp Pro Arg 
65                  70                  75                  80  


Ser Ala Ala Gly Ala Leu Val Glu Arg Pro Cys Pro Glu Tyr Phe Asn 
                85                  90                  95      


Gly Val Lys Tyr Asn Thr Thr Arg Asn Ala Tyr Arg Glu Cys Leu Glu 
            100                 105                 110         


Asn Gly Thr Trp Ala Ser Lys Ile Asn Tyr Ser Gln Cys Glu Pro Ile 
        115                 120                 125             


Leu Asp Asp Lys Gln Arg Lys Tyr Asp Leu His Tyr Arg Ile Ala Leu 
    130                 135                 140                 


Val Val Asn Tyr Leu Gly His Cys Val Ser Val Ala Ala Leu Val Ala 
145                 150                 155                 160 


Ala Phe Leu Leu Phe Leu Ala Leu Arg Ser Ile Arg Cys Leu Arg Asn 
                165                 170                 175     


Val Ile His Trp Asn Leu Ile Thr Thr Phe Ile Leu Arg Asn Val Met 
            180                 185                 190         


Trp Phe Leu Leu Gln Leu Val Asp His Glu Val His Glu Ser Asn Glu 
        195                 200                 205             


Val Trp Cys Arg Cys Ile Thr Thr Ile Phe Asn Tyr Phe Val Val Thr 
    210                 215                 220                 


Asn Phe Phe Trp Met Phe Val Glu Gly Cys Tyr Leu His Thr Ala Ile 
225                 230                 235                 240 


Val Met Thr Tyr Ser Thr Glu Arg Leu Arg Lys Cys Leu Phe Leu Phe 
                245                 250                 255     


Ile Gly Trp Cys Ile Pro Phe Pro Ile Ile Val Ala Trp Ala Ile Gly 
            260                 265                 270         


Lys Leu Tyr Tyr Glu Asn Glu Gln Cys Trp Phe Gly Lys Glu Pro Gly 
        275                 280                 285             


Asp Leu Val Asp Tyr Ile Tyr Gln Gly Pro Ile Ile Leu Val Leu Leu 
    290                 295                 300                 


Ile Asn Phe Val Phe Leu Phe Asn Ile Val Arg Ile Leu Met Thr Lys 
305                 310                 315                 320 


Leu Arg Ala Ser Thr Thr Ser Glu Thr Ile Gln Tyr Arg Lys Ala Val 
                325                 330                 335     


Lys Ala Thr Leu Val Leu Leu Pro Leu Leu Gly Ile Thr Tyr Met Leu 
            340                 345                 350         


Phe Phe Val Asn Pro Gly Glu Asp Asp Leu Ser Gln Ile Met Phe Ile 
        355                 360                 365             


Tyr Phe Asn Ser Phe Leu Gln Ser Phe Gln Gly Phe Phe Val Ser Val 
    370                 375                 380                 


Phe Tyr Cys Phe Phe Asn Gly Glu Val Arg Ser Ala Val Arg Lys Arg 
385                 390                 395                 400 


Trp His Arg Trp Gln Asp His His Ser Leu Arg Val Pro Met Ala Arg 
                405                 410                 415     


Ala Met Ser Ile Pro Thr Ser Pro Thr Arg Ile Ser Phe His Ser Ile 
            420                 425                 430         


Lys Gln Thr Ala Ala Val 
        435             


<210>  2582
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIM1__Homo_sapiens__NP_057525

<400>  2582

Met Tyr Leu Val Ala Gly Asp Arg Gly Leu Ala Gly Cys Gly His Leu 
1               5                   10                  15      


Leu Val Ser Leu Leu Gly Leu Leu Leu Leu Leu Ala Arg Ser Gly Thr 
            20                  25                  30          


Arg Ala Leu Val Cys Leu Pro Cys Asp Glu Ser Lys Cys Glu Glu Pro 
        35                  40                  45              


Arg Asn Cys Pro Gly Ser Ile Val Gln Gly Val Cys Gly Cys Cys Tyr 
    50                  55                  60                  


Thr Cys Ala Ser Gln Arg Asn Glu Ser Cys Gly Gly Thr Phe Gly Ile 
65                  70                  75                  80  


Tyr Gly Thr Cys Asp Arg Gly Leu Arg Cys Val Ile Arg Pro Pro Leu 
                85                  90                  95      


Asn Gly Asp Ser Leu Thr Glu Tyr Glu Ala Gly Val Cys Glu Asp Glu 
            100                 105                 110         


Asn Trp Thr Asp Asp Gln Leu Leu Gly Phe Lys Pro Cys Asn Glu Asn 
        115                 120                 125             


Leu Ile Ala Gly Cys Asn Ile Ile Asn Gly Lys Cys Glu Cys Asn Thr 
    130                 135                 140                 


Ile Arg Thr Cys Ser Asn Pro Phe Glu Phe Pro Ser Gln Asp Met Cys 
145                 150                 155                 160 


Leu Ser Ala Leu Lys Arg Ile Glu Glu Glu Lys Pro Asp Cys Ser Lys 
                165                 170                 175     


Ala Arg Cys Glu Val Gln Phe Ser Pro Arg Cys Pro Glu Asp Ser Val 
            180                 185                 190         


Leu Ile Glu Gly Tyr Ala Pro Pro Gly Glu Cys Cys Pro Leu Pro Ser 
        195                 200                 205             


Arg Cys Val Cys Asn Pro Ala Gly Cys Leu Arg Lys Val Cys Gln Pro 
    210                 215                 220                 


Gly Asn Leu Asn Ile Leu Val Ser Lys Ala Ser Gly Lys Pro Gly Glu 
225                 230                 235                 240 


Cys Cys Asp Leu Tyr Glu Cys Lys Pro Val Phe Gly Val Asp Cys Arg 
                245                 250                 255     


Thr Val Glu Cys Pro Pro Val Gln Gln Thr Ala Cys Pro Pro Asp Ser 
            260                 265                 270         


Tyr Glu Thr Gln Val Arg Leu Thr Ala Asp Gly Cys Cys Thr Leu Pro 
        275                 280                 285             


Thr Arg Cys Glu Cys Leu Ser Gly Leu Cys Gly Phe Pro Val Cys Glu 
    290                 295                 300                 


Val Gly Ser Thr Pro Arg Ile Val Ser Arg Gly Asp Gly Thr Pro Gly 
305                 310                 315                 320 


Lys Cys Cys Asp Val Phe Glu Cys Val Asn Asp Thr Lys Pro Ala Cys 
                325                 330                 335     


Val Phe Asn Asn Val Glu Tyr Tyr Asp Gly Asp Met Phe Arg Met Asp 
            340                 345                 350         


Asn Cys Arg Phe Cys Arg Cys Gln Gly Gly Val Ala Ile Cys Phe Thr 
        355                 360                 365             


Ala Gln Cys Gly Glu Ile Asn Cys Glu Arg Tyr Tyr Val Pro Glu Gly 
    370                 375                 380                 


Glu Cys Cys Pro Val Cys Glu Asp Pro Val Tyr Pro Phe Asn Asn Pro 
385                 390                 395                 400 


Ala Gly Cys Tyr Ala Asn Gly Leu Ile Leu Ala His Gly Asp Arg Trp 
                405                 410                 415     


Arg Glu Asp Asp Cys Thr Phe Cys Gln Cys Val Asn Gly Glu Arg His 
            420                 425                 430         


Cys Val Ala Thr Val Cys Gly Gln Thr Cys Thr Asn Pro Val Lys Val 
        435                 440                 445             


Pro Gly Glu Cys Cys Pro Val Cys Glu Glu Pro Thr Ile Ile Thr Val 
    450                 455                 460                 


Asp Pro Pro Ala Cys Gly Glu Leu Ser Asn Cys Thr Leu Thr Gly Lys 
465                 470                 475                 480 


Asp Cys Ile Asn Gly Phe Lys Arg Asp His Asn Gly Cys Arg Thr Cys 
                485                 490                 495     


Gln Cys Ile Asn Thr Glu Glu Leu Cys Ser Glu Arg Lys Gln Gly Cys 
            500                 505                 510         


Thr Leu Asn Cys Pro Phe Gly Phe Leu Thr Asp Ala Gln Asn Cys Glu 
        515                 520                 525             


Ile Cys Glu Cys Arg Pro Arg Pro Lys Lys Cys Arg Pro Ile Ile Cys 
    530                 535                 540                 


Asp Lys Tyr Cys Pro Leu Gly Leu Leu Lys Asn Lys His Gly Cys Asp 
545                 550                 555                 560 


Ile Cys Arg Cys Lys Lys Cys Pro Glu Leu Ser Cys Ser Lys Ile Cys 
                565                 570                 575     


Pro Leu Gly Phe Gln Gln Asp Ser His Gly Cys Leu Ile Cys Lys Cys 
            580                 585                 590         


Arg Glu Ala Ser Ala Ser Ala Gly Pro Pro Ile Leu Ser Gly Thr Cys 
        595                 600                 605             


Leu Thr Val Asp Gly His His His Lys Asn Glu Glu Ser Trp His Asp 
    610                 615                 620                 


Gly Cys Arg Glu Cys Tyr Cys Leu Asn Gly Arg Glu Met Cys Ala Leu 
625                 630                 635                 640 


Ile Thr Cys Pro Val Pro Ala Cys Gly Asn Pro Thr Ile His Pro Gly 
                645                 650                 655     


Gln Cys Cys Pro Ser Cys Ala Asp Asp Phe Val Val Gln Lys Pro Glu 
            660                 665                 670         


Leu Ser Thr Pro Ser Ile Cys His Ala Pro Gly Gly Glu Tyr Phe Val 
        675                 680                 685             


Glu Gly Glu Thr Trp Asn Ile Asp Ser Cys Thr Gln Cys Thr Cys His 
    690                 695                 700                 


Ser Gly Arg Val Leu Cys Glu Thr Glu Val Cys Pro Pro Leu Leu Cys 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Thr Gln Asp Ser Cys Cys Pro Gln Cys Thr Asp 
                725                 730                 735     


Gln Pro Phe Arg Pro Ser Leu Ser Arg Asn Asn Ser Val Pro Asn Tyr 
            740                 745                 750         


Cys Lys Asn Asp Glu Gly Asp Ile Phe Leu Ala Ala Glu Ser Trp Lys 
        755                 760                 765             


Pro Asp Val Cys Thr Ser Cys Ile Cys Ile Asp Ser Val Ile Ser Cys 
    770                 775                 780                 


Phe Ser Glu Ser Cys Pro Ser Val Ser Cys Glu Arg Pro Val Leu Arg 
785                 790                 795                 800 


Lys Gly Gln Cys Cys Pro Tyr Cys Ile Glu Asp Thr Ile Pro Lys Lys 
                805                 810                 815     


Val Val Cys His Phe Ser Gly Lys Ala Tyr Ala Asp Glu Glu Arg Trp 
            820                 825                 830         


Asp Leu Asp Ser Cys Thr His Cys Tyr Cys Leu Gln Gly Gln Thr Leu 
        835                 840                 845             


Cys Ser Thr Val Ser Cys Pro Pro Leu Pro Cys Val Glu Pro Ile Asn 
    850                 855                 860                 


Val Glu Gly Ser Cys Cys Pro Met Cys Pro Glu Met Tyr Val Pro Glu 
865                 870                 875                 880 


Pro Thr Asn Ile Pro Ile Glu Lys Thr Asn His Arg Gly Glu Val Asp 
                885                 890                 895     


Leu Glu Val Pro Leu Trp Pro Thr Pro Ser Glu Asn Asp Ile Val His 
            900                 905                 910         


Leu Pro Arg Asp Met Gly His Leu Gln Val Asp Tyr Arg Asp Asn Arg 
        915                 920                 925             


Leu His Pro Ser Glu Asp Ser Ser Leu Asp Ser Ile Ala Ser Val Val 
    930                 935                 940                 


Val Pro Ile Ile Ile Cys Leu Ser Ile Ile Ile Ala Phe Leu Phe Ile 
945                 950                 955                 960 


Asn Gln Lys Lys Gln Trp Ile Pro Leu Leu Cys Trp Tyr Arg Thr Pro 
                965                 970                 975     


Thr Lys Pro Ser Ser Leu Asn Asn Gln Leu Val Ser Val Asp Cys Lys 
            980                 985                 990         


Lys Gly Thr Arg Val Gln Val Asp  Ser Ser Gln Arg Met  Leu Arg Ile 
        995                 1000                 1005             


Ala Glu  Pro Asp Ala Arg Phe  Ser Gly Phe Tyr Ser  Met Gln Lys 
    1010                 1015                 1020             


Gln Asn  His Leu Gln Ala Asp  Asn Phe Tyr Gln Thr  Val 
    1025                 1030                 1035     


<210>  2583
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIP2__Homo_sapiens__NP_001257766

<400>  2583

Met Pro Pro His His Leu Leu Pro Trp Leu Ala Gln Val Pro Ser Ala 
1               5                   10                  15      


Glu Gly Glu Leu Val Arg Leu Val Ser Arg Ala Gly Gly Arg Gly Ala 
            20                  25                  30          


Cys Phe Trp Pro Ala Val Thr Met Glu Met Ala Val Ala Ala Gly Cys 
        35                  40                  45              


Val Cys Lys Gly Gly Gly Cys Cys His Arg Glu Pro Ser Gln Asp His 
    50                  55                  60                  


His Glu Ser Gln Glu His Arg Gly Pro Leu Val Gly Ser Gln Thr Cys 
65                  70                  75                  80  


Leu Val His Gln Ala Glu Gly Thr Ala Glu Lys Val Ser Ser Leu Gly 
                85                  90                  95      


Lys Asp Trp His Lys Phe Cys Leu Lys Cys Glu Arg Cys Ser Lys Thr 
            100                 105                 110         


Leu Thr Pro Gly Gly His Ala Glu His Asp Gly Lys Pro Phe Cys His 
        115                 120                 125             


Lys Pro Cys Tyr Ala Thr Leu Phe Gly Pro Lys Gly Val Asn Ile Gly 
    130                 135                 140                 


Gly Ala Gly Ser Tyr Ile Tyr Glu Lys Pro Leu Ala Glu Gly Pro Gln 
145                 150                 155                 160 


Val Thr Gly Pro Ile Glu Val Pro Ala Ala Arg Ala Glu Glu Arg Lys 
                165                 170                 175     


Ala Ser Gly Pro Pro Lys Gly Pro Ser Arg Ala Ser Ser Val Thr Thr 
            180                 185                 190         


Phe Thr Gly Glu Pro Asn Thr Cys Pro Arg Cys Ser Lys Lys Val Tyr 
        195                 200                 205             


Phe Ala Glu Lys Val Thr Ser Leu Gly Lys Asp Trp His Arg Pro Cys 
    210                 215                 220                 


Leu Arg Cys Glu Arg Cys Gly Lys Thr Leu Thr Pro Gly Gly His Ala 
225                 230                 235                 240 


Glu His Asp Gly Gln Pro Tyr Cys His Lys Pro Cys Tyr Gly Ile Leu 
                245                 250                 255     


Phe Gly Pro Lys Gly Val Asn Thr Gly Ala Val Gly Ser Tyr Ile Tyr 
            260                 265                 270         


Asp Arg Asp Pro Glu Gly Lys Val Gln Pro 
        275                 280         


<210>  2584
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIP3__Homo_sapiens__NP_996805

<400>  2584

Met Ser Trp Thr Cys Pro Arg Cys Gln Gln Pro Val Phe Phe Ala Glu 
1               5                   10                  15      


Lys Val Ser Ser Leu Gly Lys Asn Trp His Arg Phe Cys Leu Lys Cys 
            20                  25                  30          


Glu Arg Cys His Ser Ile Leu Ser Pro Gly Gly His Ala Glu His Asn 
        35                  40                  45              


Gly Arg Pro Tyr Cys His Lys Pro Cys Tyr Gly Ala Leu Phe Gly Pro 
    50                  55                  60                  


Arg Gly Val Asn Ile Gly Gly Val Gly Ser Tyr Leu Tyr Asn Pro Pro 
65                  70                  75                  80  


Thr Pro Ser Pro Gly Cys Thr Thr Pro Leu Ser Pro Ser Ser Phe Ser 
                85                  90                  95      


Pro Pro Arg Pro Arg Thr Gly Leu Pro Gln Gly Lys Lys Ser Pro Pro 
            100                 105                 110         


His Met Lys Thr Phe Thr Gly Glu Thr Ser Leu Cys Pro Gly Cys Gly 
        115                 120                 125             


Glu Pro Val Tyr Phe Ala Glu Lys Val Met Ser Leu Gly Arg Asn Trp 
    130                 135                 140                 


His Arg Pro Cys Leu Arg Cys Gln Arg Cys His Lys Thr Leu Thr Ala 
145                 150                 155                 160 


Gly Ser His Ala Glu His Asp Gly Val Pro Tyr Cys His Val Pro Cys 
                165                 170                 175     


Tyr Gly Tyr Leu Phe Gly Pro Lys Gly Val Asn Ile Gly Asp Val Gly 
            180                 185                 190         


Cys Tyr Ile Tyr Asp Pro Val Lys Ile Lys Phe Lys 
        195                 200                 


<210>  2585
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIPAK__Homo_sapiens__NP_787114

<400>  2585

Met His Glu Pro Ser Leu Cys Ala Asn Val Glu Cys Pro Pro Ala His 
1               5                   10                  15      


Thr Cys Pro Cys Gly Val Pro Ala Cys Ser Cys Ala His Val Glu Cys 
            20                  25                  30          


Pro Pro Ala His Thr Cys Arg Cys Gly Val Pro Ala Cys Ser His Met 
        35                  40                  45              


Pro Met Trp Ser Ala Arg Leu Leu Thr Arg Ala His Val Glu Cys Pro 
    50                  55                  60                  


Pro Ala His Thr Arg Val His Val Glu Cys Pro Pro Ala His Val Pro 
65                  70                  75                  80  


Met Trp Ser Ala His Leu Leu Thr Cys Ala Asp Val Glu Cys His Leu 
                85                  90                  95      


Leu Thr His Val Pro Met Trp Ser Ala Arg Leu Leu Thr Cys Pro Cys 
            100                 105                 110         


Gly Val Pro Ala Cys Ser His Val Pro Met Arg Ser Ala Arg Leu Leu 
        115                 120                 125             


Thr Arg Ala His Ala Glu Cys Pro Pro Ala His Thr Cys Pro Cys Gly 
    130                 135                 140                 


Val Pro Ala Cys Ser His Val Pro Met Arg Ser Ala Arg Leu Leu Thr 
145                 150                 155                 160 


Arg Ala Asp Val Glu Cys Pro Pro Ala His Thr Cys Pro Cys Gly Val 
                165                 170                 175     


Pro Ala Cys Ser His Val Pro Thr Trp Ser Ala Arg Leu Ile Thr Arg 
            180                 185                 190         


Ala His Val Glu Cys Ser Pro Ala His Thr Cys Arg Cys Gly Val Pro 
        195                 200                 205             


Ala Cys Ser His Val Pro Met Trp Ser Val Arg Leu Leu Thr Arg Ala 
    210                 215                 220                 


Asp Ala Glu Cys Pro Pro Ala His Thr Cys Arg Cys Gly Val Pro Ala 
225                 230                 235                 240 


Cys Ser His Val Pro Met Trp Ser Ala Arg Leu Leu Thr Cys Arg Cys 
                245                 250                 255     


Gly Val Pro Ala Cys Ser His Val Pro Met Trp Ser Ala Arg Leu Leu 
            260                 265                 270         


Thr Cys Arg Cys Gly Val Pro Ala Cys Ser His Val Pro Met Trp Ser 
        275                 280                 285             


Ala Arg Leu Leu Thr Arg Ala His Val Glu Cys Pro Pro Ala His Thr 
    290                 295                 300                 


Cys Arg Arg Gly Val Pro Ala Cys Ser Arg Ala His Met Glu Cys Pro 
305                 310                 315                 320 


Pro Ala His Thr Cys His Cys Gly Val Pro Ala Cys Ser His Thr Cys 
                325                 330                 335     


Arg Cys Gly Val Pro Ala Cys Ser His Val Pro Met Trp Ser Ala Arg 
            340                 345                 350         


Leu Leu Thr Arg Ala His Val Glu Cys Pro Pro Ala His Thr Arg Ala 
        355                 360                 365             


His Val Glu Cys Pro Pro Ala His Thr Cys Pro Cys Gly Val Pro Ala 
    370                 375                 380                 


Cys Ser His Thr Cys Pro Cys Gly Val Pro Ala Cys Ser His Lys Ala 
385                 390                 395                 400 


Leu Ala Trp Trp Phe Cys Arg Phe Pro Val Leu Pro Ala Glu Ser Asp 
                405                 410                 415     


Ala Val Thr Val His Ser Thr His Gly Gly Phe Leu Ile Arg Phe Tyr 
            420                 425                 430         


Val Lys Asp Pro Phe Tyr Ile Ser Leu His Leu Glu Ile Thr 
        435                 440                 445     


<210>  2586
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRIPT__Homo_sapiens__NP_054890

<400>  2586

Met Val Cys Glu Lys Cys Glu Lys Lys Leu Gly Thr Val Ile Thr Pro 
1               5                   10                  15      


Asp Thr Trp Lys Asp Gly Ala Arg Asn Thr Thr Glu Ser Gly Gly Arg 
            20                  25                  30          


Lys Leu Asn Glu Asn Lys Ala Leu Thr Ser Lys Lys Ala Arg Phe Asp 
        35                  40                  45              


Pro Tyr Gly Lys Asn Lys Phe Ser Thr Cys Arg Ile Cys Lys Ser Ser 
    50                  55                  60                  


Val His Gln Pro Gly Ser His Tyr Cys Gln Gly Cys Ala Tyr Lys Lys 
65                  70                  75                  80  


Gly Ile Cys Ala Met Cys Gly Lys Lys Val Leu Asp Thr Lys Asn Tyr 
                85                  90                  95      


Lys Gln Thr Ser Val 
            100     


<210>  2587
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRISP1__Homo_sapiens__NP_001122

<400>  2587

Met Glu Ile Lys His Leu Leu Phe Leu Val Ala Ala Ala Cys Leu Leu 
1               5                   10                  15      


Pro Met Leu Ser Met Lys Lys Lys Ser Ala Arg Asp Gln Phe Asn Lys 
            20                  25                  30          


Leu Val Thr Asp Leu Pro Asn Val Gln Glu Glu Ile Val Asn Ile His 
        35                  40                  45              


Asn Ala Leu Arg Arg Arg Val Val Pro Pro Ala Ser Asn Met Leu Lys 
    50                  55                  60                  


Met Ser Trp Ser Glu Glu Ala Ala Gln Asn Ala Arg Ile Phe Ser Lys 
65                  70                  75                  80  


Tyr Cys Asp Met Thr Glu Ser Asn Pro Leu Glu Arg Arg Leu Pro Asn 
                85                  90                  95      


Thr Phe Cys Gly Glu Asn Met His Met Thr Ser Tyr Pro Val Ser Trp 
            100                 105                 110         


Ser Ser Val Ile Gly Val Trp Tyr Ser Glu Ser Thr Ser Phe Lys His 
        115                 120                 125             


Gly Glu Trp Thr Thr Thr Asp Asp Asp Ile Thr Thr Asp His Tyr Thr 
    130                 135                 140                 


Gln Ile Val Trp Ala Thr Ser Tyr Leu Ile Gly Cys Ala Ile Ala Ser 
145                 150                 155                 160 


Cys Arg Gln Gln Gly Ser Pro Arg Tyr Leu Tyr Val Cys His Tyr Cys 
                165                 170                 175     


His Glu Gly Asn Asp Pro Glu Thr Lys Asn Glu Pro Tyr Lys Thr Gly 
            180                 185                 190         


Val Pro Cys Glu Ala Cys Pro Ser Asn Cys Glu Asp Lys Leu Cys Thr 
        195                 200                 205             


Asn Pro Cys Ile Tyr Tyr Asp Glu Tyr Phe Asp Cys Asp Ile Gln Val 
    210                 215                 220                 


His Tyr Leu Gly Cys Asn His Ser Thr Thr Ile Leu Phe Cys Lys Ala 
225                 230                 235                 240 


Thr Cys Leu Cys Asp Thr Glu Ile Lys 
                245                 


<210>  2588
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRISP2__Homo_sapiens__NP_001135879

<400>  2588

Met Ala Leu Leu Pro Val Leu Phe Leu Val Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Leu Pro Ala Glu Gly Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr 
            20                  25                  30          


Gln Leu Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg 
        35                  40                  45              


Lys Ala Val Ser Pro Pro Ala Ser Asn Met Leu Lys Met Glu Trp Ser 
    50                  55                  60                  


Arg Glu Val Thr Thr Asn Ala Gln Arg Trp Ala Asn Lys Cys Thr Leu 
65                  70                  75                  80  


Gln His Ser Asp Pro Glu Asp Arg Lys Thr Ser Thr Arg Cys Gly Glu 
                85                  90                  95      


Asn Leu Tyr Met Ser Ser Asp Pro Thr Ser Trp Ser Ser Ala Ile Gln 
            100                 105                 110         


Ser Trp Tyr Asp Glu Ile Leu Asp Phe Val Tyr Gly Val Gly Pro Lys 
        115                 120                 125             


Ser Pro Asn Ala Val Val Gly His Tyr Thr Gln Leu Val Trp Tyr Ser 
    130                 135                 140                 


Thr Tyr Gln Val Gly Cys Gly Ile Ala Tyr Cys Pro Asn Gln Asp Ser 
145                 150                 155                 160 


Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Asn Met 
                165                 170                 175     


Asn Arg Lys Asn Thr Pro Tyr Gln Gln Gly Thr Pro Cys Ala Gly Cys 
            180                 185                 190         


Pro Asp Asp Cys Asp Lys Gly Leu Cys Thr Asn Ser Cys Gln Tyr Gln 
        195                 200                 205             


Asp Leu Leu Ser Asn Cys Asp Ser Leu Lys Asn Thr Ala Gly Cys Glu 
    210                 215                 220                 


His Glu Leu Leu Lys Glu Lys Cys Lys Ala Thr Cys Leu Cys Glu Asn 
225                 230                 235                 240 


Lys Ile Tyr 
            


<210>  2589
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRISP3__Homo_sapiens__NP_001177915

<400>  2589

Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Asp Pro Cys Ser 
1               5                   10                  15      


Thr Gly Phe Val Phe Pro Ala Met Thr Leu Phe Pro Val Leu Leu Phe 
            20                  25                  30          


Leu Val Ala Gly Leu Leu Pro Ser Phe Pro Ala Asn Glu Asp Lys Asp 
        35                  40                  45              


Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln Thr Gln Val Gln Arg Glu 
    50                  55                  60                  


Ile Val Asn Lys His Asn Glu Leu Arg Arg Ala Val Ser Pro Pro Ala 
65                  70                  75                  80  


Arg Asn Met Leu Lys Met Glu Trp Asn Lys Glu Ala Ala Ala Asn Ala 
                85                  90                  95      


Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg His Ser Asn Pro Lys Asp 
            100                 105                 110         


Arg Met Thr Ser Leu Lys Cys Gly Glu Asn Leu Tyr Met Ser Ser Ala 
        115                 120                 125             


Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser Trp Phe Asp Glu Tyr Asn 
    130                 135                 140                 


Asp Phe Asp Phe Gly Val Gly Pro Lys Thr Pro Asn Ala Val Val Gly 
145                 150                 155                 160 


His Tyr Thr Gln Val Val Trp Tyr Ser Ser Tyr Leu Val Gly Cys Gly 
                165                 170                 175     


Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu Lys Tyr Tyr Tyr Val Cys 
            180                 185                 190         


Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn Arg Leu Tyr Val Pro Tyr 
        195                 200                 205             


Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro Asp Asn Cys Asp Asp Gly 
    210                 215                 220                 


Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp Leu Tyr Ser Asn Cys Lys 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Leu Thr Cys Lys His Gln Leu Val Arg Asp Ser 
                245                 250                 255     


Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser Ile Tyr 
            260                 265             


<210>  2590
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRISPLD1__Homo_sapiens__NP_001273707

<400>  2590

Met Asn Ile Trp Gly Gln Ile Trp Pro Lys Ala Val Tyr Leu Val Cys 
1               5                   10                  15      


Asn Tyr Ser Pro Lys Gly Asn Trp Trp Gly His Ala Pro Tyr Lys His 
            20                  25                  30          


Gly Arg Pro Cys Ser Ala Cys Pro Pro Ser Phe Gly Gly Gly Cys Arg 
        35                  40                  45              


Glu Asn Leu Cys Tyr Lys Glu Gly Ser Asp Arg Tyr Tyr Pro Pro Arg 
    50                  55                  60                  


Glu Glu Glu Thr Asn Glu Ile Glu Arg Gln Gln Ser Gln Val His Asp 
65                  70                  75                  80  


Thr His Val Arg Thr Arg Ser Asp Asp Ser Ser Arg Asn Glu Val Ile 
                85                  90                  95      


Ser Ala Gln Gln Met Ser Gln Ile Val Ser Cys Glu Val Arg Leu Arg 
            100                 105                 110         


Asp Gln Cys Lys Gly Thr Thr Cys Asn Arg Tyr Glu Cys Pro Ala Gly 
        115                 120                 125             


Cys Leu Asp Ser Lys Ala Lys Val Ile Gly Ser Val His Tyr Glu Met 
    130                 135                 140                 


Gln Ser Ser Ile Cys Arg Ala Ala Ile His Tyr Gly Ile Ile Asp Asn 
145                 150                 155                 160 


Asp Gly Gly Trp Val Asp Ile Thr Arg Gln Gly Arg Lys His Tyr Phe 
                165                 170                 175     


Ile Lys Ser Asn Arg Asn Gly Ile Gln Thr Ile Gly Lys Tyr Gln Ser 
            180                 185                 190         


Ala Asn Ser Phe Thr Val Ser Lys Val Thr Val Gln Ala Val Thr Cys 
        195                 200                 205             


Glu Thr Thr Val Glu Gln Leu Cys Pro Phe His Lys Pro Ala Ser His 
    210                 215                 220                 


Cys Pro Arg Val Tyr Cys Pro Arg Asn Cys Met Gln Ala Asn Pro His 
225                 230                 235                 240 


Tyr Ala Arg Val Ile Gly Thr Arg Val Tyr Ser Asp Leu Ser Ser Ile 
                245                 250                 255     


Cys Arg Ala Ala Val His Ala Gly Val Val Arg Asn His Gly Gly Tyr 
            260                 265                 270         


Val Asp Val Met Pro Val Asp Lys Arg Lys Thr Tyr Ile Ala Ser Phe 
        275                 280                 285             


Gln Asn Gly Ile Phe Ser Glu Ser Leu Gln Asn Pro Pro Gly Gly Lys 
    290                 295                 300                 


Ala Phe Arg Val Phe Ala Val Val 
305                 310         


<210>  2591
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRISPLD2__Homo_sapiens__NP_113664

<400>  2591

Met Ser Cys Val Leu Gly Gly Val Ile Pro Leu Gly Leu Leu Phe Leu 
1               5                   10                  15      


Val Cys Gly Ser Gln Gly Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu 
            20                  25                  30          


Glu Leu Leu Ser Lys Tyr Gln His Asn Glu Ser His Ser Arg Val Arg 
        35                  40                  45              


Arg Ala Ile Pro Arg Glu Asp Lys Glu Glu Ile Leu Met Leu His Asn 
    50                  55                  60                  


Lys Leu Arg Gly Gln Val Gln Pro Gln Ala Ser Asn Met Glu Tyr Met 
65                  70                  75                  80  


Thr Trp Asp Asp Glu Leu Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln 
                85                  90                  95      


Cys Ile Trp Glu His Gly Pro Thr Ser Leu Leu Val Ser Ile Gly Gln 
            100                 105                 110         


Asn Leu Gly Ala His Trp Gly Arg Tyr Arg Ser Pro Gly Phe His Val 
        115                 120                 125             


Gln Ser Trp Tyr Asp Glu Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser 
    130                 135                 140                 


Glu Cys Asn Pro Trp Cys Pro Glu Arg Cys Ser Gly Pro Met Cys Thr 
145                 150                 155                 160 


His Tyr Thr Gln Ile Val Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala 
                165                 170                 175     


Val Asn Thr Cys Arg Lys Met Thr Val Trp Gly Glu Val Trp Glu Asn 
            180                 185                 190         


Ala Val Tyr Phe Val Cys Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly 
        195                 200                 205             


Glu Ala Pro Tyr Lys Asn Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser 
    210                 215                 220                 


Tyr Gly Gly Ser Cys Arg Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr 
225                 230                 235                 240 


Thr Pro Lys Pro Glu Thr Asp Glu Met Asn Glu Val Glu Thr Ala Pro 
                245                 250                 255     


Ile Pro Glu Glu Asn His Val Trp Leu Gln Pro Arg Val Met Arg Pro 
            260                 265                 270         


Thr Lys Pro Lys Lys Thr Ser Ala Val Asn Tyr Met Thr Gln Val Val 
        275                 280                 285             


Arg Cys Asp Thr Lys Met Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn 
    290                 295                 300                 


Arg Tyr Gln Cys Pro Ala Gly Cys Leu Asn His Lys Ala Lys Ile Phe 
305                 310                 315                 320 


Gly Thr Leu Phe Tyr Glu Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile 
                325                 330                 335     


His Tyr Gly Ile Leu Asp Asp Lys Gly Gly Leu Val Asp Ile Thr Arg 
            340                 345                 350         


Asn Gly Lys Val Pro Phe Phe Val Lys Ser Glu Arg His Gly Val Gln 
        355                 360                 365             


Ser Leu Ser Lys Tyr Lys Pro Ser Ser Ser Phe Met Val Ser Lys Val 
    370                 375                 380                 


Lys Val Gln Asp Leu Asp Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro 
385                 390                 395                 400 


Phe Glu Lys Pro Ala Thr His Cys Pro Arg Ile His Cys Pro Ala His 
                405                 410                 415     


Cys Lys Asp Glu Pro Ser Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile 
            420                 425                 430         


Tyr Ala Asp Thr Ser Ser Ile Cys Lys Thr Ala Val His Ala Gly Val 
        435                 440                 445             


Ile Ser Asn Glu Ser Gly Gly Asp Val Asp Val Met Pro Val Asp Lys 
    450                 455                 460                 


Lys Lys Thr Tyr Val Gly Ser Leu Arg Asn Gly Val Gln Ser Glu Ser 
465                 470                 475                 480 


Leu Gly Thr Pro Arg Asp Gly Lys Ala Phe Arg Ile Phe Ala Val Arg 
                485                 490                 495     


Gln 
    


<210>  2592
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRK__Homo_sapiens__NP_005197

<400>  2592

Met Ala Gly Asn Phe Asp Ser Glu Glu Arg Ser Ser Trp Tyr Trp Gly 
1               5                   10                  15      


Arg Leu Ser Arg Gln Glu Ala Val Ala Leu Leu Gln Gly Gln Arg His 
            20                  25                  30          


Gly Val Phe Leu Val Arg Asp Ser Ser Thr Ser Pro Gly Asp Tyr Val 
        35                  40                  45              


Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn Ser 
    50                  55                  60                  


Ser Gly Pro Arg Pro Pro Val Pro Pro Ser Pro Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Gly Val Ser Pro Ser Arg Leu Arg Ile Gly Asp Gln Glu Phe Asp Ser 
                85                  90                  95      


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
            100                 105                 110         


Thr Leu Ile Glu Pro Val Ser Arg Ser Arg Gln Gly Ser Gly Val Ile 
        115                 120                 125             


Leu Arg Gln Glu Glu Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn 
    130                 135                 140                 


Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg 
145                 150                 155                 160 


Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu 
                165                 170                 175     


Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Arg Pro 
            180                 185                 190         


Ala Ser Ala Ser Val Ser Ala Leu Ile Gly Gly Arg 
        195                 200                 


<210>  2593
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRKL__Homo_sapiens__NP_005198

<400>  2593

Met Ser Ser Ala Arg Phe Asp Ser Ser Asp Arg Ser Ala Trp Tyr Met 
1               5                   10                  15      


Gly Pro Val Ser Arg Gln Glu Ala Gln Thr Arg Leu Gln Gly Gln Arg 
            20                  25                  30          


His Gly Met Phe Leu Val Arg Asp Ser Ser Thr Cys Pro Gly Asp Tyr 
        35                  40                  45              


Val Leu Ser Val Ser Glu Asn Ser Arg Val Ser His Tyr Ile Ile Asn 
    50                  55                  60                  


Ser Leu Pro Asn Arg Arg Phe Lys Ile Gly Asp Gln Glu Phe Asp His 
65                  70                  75                  80  


Leu Pro Ala Leu Leu Glu Phe Tyr Lys Ile His Tyr Leu Asp Thr Thr 
                85                  90                  95      


Thr Leu Ile Glu Pro Ala Pro Arg Tyr Pro Ser Pro Pro Met Gly Ser 
            100                 105                 110         


Val Ser Ala Pro Asn Leu Pro Thr Ala Glu Asp Asn Leu Glu Tyr Val 
        115                 120                 125             


Arg Thr Leu Tyr Asp Phe Pro Gly Asn Asp Ala Glu Asp Leu Pro Phe 
    130                 135                 140                 


Lys Lys Gly Glu Ile Leu Val Ile Ile Glu Lys Pro Glu Glu Gln Trp 
145                 150                 155                 160 


Trp Ser Ala Arg Asn Lys Asp Gly Arg Val Gly Met Ile Pro Val Pro 
                165                 170                 175     


Tyr Val Glu Lys Leu Val Arg Ser Ser Pro His Gly Lys His Gly Asn 
            180                 185                 190         


Arg Asn Ser Asn Ser Tyr Gly Ile Pro Glu Pro Ala His Ala Tyr Ala 
        195                 200                 205             


Gln Pro Gln Thr Thr Thr Pro Leu Pro Ala Val Ser Gly Ser Pro Gly 
    210                 215                 220                 


Ala Ala Ile Thr Pro Leu Pro Ser Thr Gln Asn Gly Pro Val Phe Ala 
225                 230                 235                 240 


Lys Ala Ile Gln Lys Arg Val Pro Cys Ala Tyr Asp Lys Thr Ala Leu 
                245                 250                 255     


Ala Leu Glu Val Gly Asp Ile Val Lys Val Thr Arg Met Asn Ile Asn 
            260                 265                 270         


Gly Gln Trp Glu Gly Glu Val Asn Gly Arg Lys Gly Leu Phe Pro Phe 
        275                 280                 285             


Thr His Val Lys Ile Phe Asp Pro Gln Asn Pro Asp Glu Asn Glu 
    290                 295                 300             


<210>  2594
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRLF1__Homo_sapiens__NP_004741

<400>  2594

Met Pro Ala Gly Arg Arg Gly Pro Ala Ala Gln Ser Ala Arg Arg Pro 
1               5                   10                  15      


Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu Cys Val Leu Gly Ala Pro 
            20                  25                  30          


Arg Ala Gly Ser Gly Ala His Thr Ala Val Ile Ser Pro Gln Asp Pro 
        35                  40                  45              


Thr Leu Leu Ile Gly Ser Ser Leu Leu Ala Thr Cys Ser Val His Gly 
    50                  55                  60                  


Asp Pro Pro Gly Ala Thr Ala Glu Gly Leu Tyr Trp Thr Leu Asn Gly 
65                  70                  75                  80  


Arg Arg Leu Pro Pro Glu Leu Ser Arg Val Leu Asn Ala Ser Thr Leu 
                85                  90                  95      


Ala Leu Ala Leu Ala Asn Leu Asn Gly Ser Arg Gln Arg Ser Gly Asp 
            100                 105                 110         


Asn Leu Val Cys His Ala Arg Asp Gly Ser Ile Leu Ala Gly Ser Cys 
        115                 120                 125             


Leu Tyr Val Gly Leu Pro Pro Glu Lys Pro Val Asn Ile Ser Cys Trp 
    130                 135                 140                 


Ser Lys Asn Met Lys Asp Leu Thr Cys Arg Trp Thr Pro Gly Ala His 
145                 150                 155                 160 


Gly Glu Thr Phe Leu His Thr Asn Tyr Ser Leu Lys Tyr Lys Leu Arg 
                165                 170                 175     


Trp Tyr Gly Gln Asp Asn Thr Cys Glu Glu Tyr His Thr Val Gly Pro 
            180                 185                 190         


His Ser Cys His Ile Pro Lys Asp Leu Ala Leu Phe Thr Pro Tyr Glu 
        195                 200                 205             


Ile Trp Val Glu Ala Thr Asn Arg Leu Gly Ser Ala Arg Ser Asp Val 
    210                 215                 220                 


Leu Thr Leu Asp Ile Leu Asp Val Val Thr Thr Asp Pro Pro Pro Asp 
225                 230                 235                 240 


Val His Val Ser Arg Val Gly Gly Leu Glu Asp Gln Leu Ser Val Arg 
                245                 250                 255     


Trp Val Ser Pro Pro Ala Leu Lys Asp Phe Leu Phe Gln Ala Lys Tyr 
            260                 265                 270         


Gln Ile Arg Tyr Arg Val Glu Asp Ser Val Asp Trp Lys Val Val Asp 
        275                 280                 285             


Asp Val Ser Asn Gln Thr Ser Cys Arg Leu Ala Gly Leu Lys Pro Gly 
    290                 295                 300                 


Thr Val Tyr Phe Val Gln Val Arg Cys Asn Pro Phe Gly Ile Tyr Gly 
305                 310                 315                 320 


Ser Lys Lys Ala Gly Ile Trp Ser Glu Trp Ser His Pro Thr Ala Ala 
                325                 330                 335     


Ser Thr Pro Arg Ser Glu Arg Pro Gly Pro Gly Gly Gly Ala Cys Glu 
            340                 345                 350         


Pro Arg Gly Gly Glu Pro Ser Ser Gly Pro Val Arg Arg Glu Leu Lys 
        355                 360                 365             


Gln Phe Leu Gly Trp Leu Lys Lys His Ala Tyr Cys Ser Asn Leu Ser 
    370                 375                 380                 


Phe Arg Leu Tyr Asp Gln Trp Arg Ala Trp Met Gln Lys Ser His Lys 
385                 390                 395                 400 


Thr Arg Asn Gln Asp Glu Gly Ile Leu Pro Ser Gly Arg Arg Gly Thr 
                405                 410                 415     


Ala Arg Gly Pro Ala Arg 
            420         


<210>  2595
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRLF2__Homo_sapiens__NP_071431

<400>  2595

Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly 
1               5                   10                  15      


Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Ala Glu Gly Val Gln Ile 
            20                  25                  30          


Gln Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala 
        35                  40                  45              


Ser Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly 
    50                  55                  60                  


Asp Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His 
65                  70                  75                  80  


Thr Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr 
                85                  90                  95      


Phe Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp 
            100                 105                 110         


Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 
        115                 120                 125             


Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 
    130                 135                 140                 


Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 
145                 150                 155                 160 


Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp 
                165                 170                 175     


Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp 
            180                 185                 190         


Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys 
        195                 200                 205             


Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro 
    210                 215                 220                 


Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile 
225                 230                 235                 240 


Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg 
                245                 250                 255     


Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe 
            260                 265                 270         


Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr 
        275                 280                 285             


Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln 
    290                 295                 300                 


Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu 
305                 310                 315                 320 


Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala 
                325                 330                 335     


Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp 
            340                 345                 350         


Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr 
        355                 360                 365             


Val Ala Leu 
    370     


<210>  2596
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRLF3__Homo_sapiens__NP_057070

<400>  2596

Met Arg Gly Ala Met Glu Leu Glu Pro Glu Leu Leu Leu Gln Glu Ala 
1               5                   10                  15      


Arg Glu Asn Val Glu Ala Ala Gln Ser Tyr Arg Arg Glu Leu Gly His 
            20                  25                  30          


Arg Leu Glu Gly Leu Arg Glu Ala Arg Arg Gln Ile Lys Glu Ser Ala 
        35                  40                  45              


Ser Gln Thr Arg Asp Val Leu Lys Gln His Phe Asn Asp Leu Lys Gly 
    50                  55                  60                  


Thr Leu Gly Lys Leu Leu Asp Glu Arg Leu Val Thr Leu Leu Gln Glu 
65                  70                  75                  80  


Val Asp Thr Ile Glu Gln Glu Thr Ile Lys Pro Leu Asp Asp Cys Gln 
                85                  90                  95      


Lys Leu Ile Glu His Gly Val Asn Thr Ala Glu Asp Leu Val Arg Glu 
            100                 105                 110         


Gly Glu Ile Ala Met Leu Gly Gly Val Gly Glu Glu Asn Glu Lys Leu 
        115                 120                 125             


Trp Ser Phe Thr Lys Lys Ala Ser His Ile Gln Leu Asp Ser Leu Pro 
    130                 135                 140                 


Glu Val Pro Leu Leu Val Asp Val Pro Cys Leu Ser Ala Gln Leu Asp 
145                 150                 155                 160 


Asp Ser Ile Leu Asn Ile Val Lys Asp His Ile Phe Lys His Gly Thr 
                165                 170                 175     


Val Ala Ser Arg Pro Pro Val Gln Ile Glu Glu Leu Ile Glu Lys Pro 
            180                 185                 190         


Gly Gly Ile Ile Val Arg Trp Cys Lys Val Asp Asp Asp Phe Thr Ala 
        195                 200                 205             


Gln Asp Tyr Arg Leu Gln Phe Arg Lys Cys Thr Ser Asn His Phe Glu 
    210                 215                 220                 


Asp Val Tyr Val Gly Ser Glu Thr Glu Phe Ile Val Leu His Ile Asp 
225                 230                 235                 240 


Pro Asn Val Asp Tyr Gln Phe Arg Val Cys Ala Arg Gly Asp Gly Arg 
                245                 250                 255     


Gln Glu Trp Ser Pro Trp Ser Val Pro Gln Ile Gly His Ser Thr Leu 
            260                 265                 270         


Val Pro His Glu Trp Thr Ala Gly Phe Glu Gly Tyr Ser Leu Ser Ser 
        275                 280                 285             


Arg Arg Asn Ile Ala Leu Arg Asn Asp Ser Glu Ser Ser Gly Val Leu 
    290                 295                 300                 


Tyr Ser Arg Ala Pro Thr Tyr Phe Cys Gly Gln Thr Leu Thr Phe Arg 
305                 310                 315                 320 


Val Glu Thr Val Gly Gln Pro Asp Arg Arg Asp Ser Ile Gly Val Cys 
                325                 330                 335     


Ala Glu Lys Gln Asp Gly Tyr Asp Ser Leu Gln Arg Asp Gln Ala Val 
            340                 345                 350         


Cys Ile Ser Thr Asn Gly Ala Val Phe Val Asn Gly Lys Glu Met Thr 
        355                 360                 365             


Asn Gln Leu Pro Ala Val Thr Ser Gly Ser Thr Val Thr Phe Asp Ile 
    370                 375                 380                 


Glu Ala Val Thr Leu Gly Thr Thr Ser Asn Asn Glu Gly Gly His Phe 
385                 390                 395                 400 


Lys Leu Arg Val Thr Ile Ser Ser Asn Asn Arg Glu Val Val Phe Asp 
                405                 410                 415     


Trp Leu Leu Asp Gln Ser Cys Gly Ser Leu Tyr Phe Gly Cys Ser Phe 
            420                 425                 430         


Phe Tyr Pro Gly Trp Lys Val Leu Val Phe 
        435                 440         


<210>  2597
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRLS1__Homo_sapiens__NP_001120930

<400>  2597

Met Pro Gln Tyr Glu Asn Pro Trp Thr Ile Pro Asn Met Leu Ser Met 
1               5                   10                  15      


Thr Arg Ile Gly Leu Ala Pro Val Leu Gly Tyr Leu Ile Ile Glu Glu 
            20                  25                  30          


Asp Phe Asn Ile Ala Leu Gly Val Phe Ala Leu Ala Gly Leu Thr Asp 
        35                  40                  45              


Leu Leu Asp Gly Phe Ile Ala Arg Asn Trp Ala Asn Gln Arg Ser Ala 
    50                  55                  60                  


Leu Gly Ser Ala Leu Asp Pro Leu Ala Asp Lys Ile Leu Ile Ser Ile 
65                  70                  75                  80  


Leu Tyr Val Ser Leu Thr Tyr Ala Asp Leu Ile Pro Val Pro Leu Thr 
                85                  90                  95      


Tyr Met Ile Ile Ser Arg Asp Val Met Leu Ile Ala Ala Val Phe Tyr 
            100                 105                 110         


Val Arg Tyr Arg Thr Leu Pro Thr Pro Arg Thr Leu Ala Lys Tyr Phe 
        115                 120                 125             


Asn Pro Cys Tyr Ala Thr Ala Arg Leu Lys Pro Thr Phe Ile Ser Lys 
    130                 135                 140                 


Val Asn Thr Ala Val Gln Leu Ile Leu Val Ala Ala Ser Leu Ala Ala 
145                 150                 155                 160 


Pro Val Phe Asn Tyr Ala Asp Ser Ile Tyr Leu Gln Ile Leu Trp Cys 
                165                 170                 175     


Phe Thr Ala Phe Thr Thr Ala Ala Ser Ala Tyr Ser Tyr Tyr His Tyr 
            180                 185                 190         


Gly Arg Lys Thr Val Gln Val Ile Lys Asp 
        195                 200         


<210>  2598
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRMP1__Homo_sapiens__NP_001014809

<400>  2598

Met Ala Asp Arg Arg Arg Ala Trp Asn Thr Glu Asp Asp Leu Pro Val 
1               5                   10                  15      


Tyr Leu Ala Arg Pro Gly Ser Ala Ala Gln Thr Pro Arg Gln Lys Tyr 
            20                  25                  30          


Gly Gly Met Phe Ala Ala Val Glu Gly Ala Tyr Glu Asn Lys Thr Ile 
        35                  40                  45              


Asp Phe Asp Ala Tyr Ser Val Gly Arg Arg Gly Ser Ala Arg Thr Pro 
    50                  55                  60                  


Arg Ser Ala Gly Arg Pro Asp Ala Val Gly Leu Pro Gly Pro Gly Gly 
65                  70                  75                  80  


Ser Glu Asp Thr Ala Ser Asp Val Ser Glu Pro Ser Gly Ser Ala Val 
                85                  90                  95      


Ser Ser Pro Gly Glu Arg Asp Glu Arg Pro Pro Thr Leu Arg Ile Arg 
            100                 105                 110         


Arg Pro Ala Pro Arg Asp Leu Pro Leu Gly Arg Asp Asn Gly Gln Ser 
        115                 120                 125             


Asp Arg Leu Leu Ile Lys Gly Gly Arg Ile Ile Asn Asp Asp Gln Ser 
    130                 135                 140                 


Leu Tyr Ala Asp Val Tyr Leu Glu Asp Gly Leu Ile Lys Gln Ile Gly 
145                 150                 155                 160 


Glu Asn Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly 
                165                 170                 175     


Arg Met Val Ile Pro Gly Gly Ile Asp Val Asn Thr Tyr Leu Gln Lys 
            180                 185                 190         


Pro Ser Gln Gly Met Thr Ala Ala Asp Asp Phe Phe Gln Gly Thr Arg 
        195                 200                 205             


Ala Ala Leu Val Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro 
    210                 215                 220                 


Glu Pro Gly Ser Ser Leu Leu Thr Ser Phe Glu Lys Trp His Glu Ala 
225                 230                 235                 240 


Ala Asp Thr Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr 
                245                 250                 255     


Ser Trp Tyr Asp Gly Val Arg Glu Glu Leu Glu Val Leu Val Gln Asp 
            260                 265                 270         


Lys Gly Val Asn Ser Phe Gln Val Tyr Met Ala Tyr Lys Asp Val Tyr 
        275                 280                 285             


Gln Met Ser Asp Ser Gln Leu Tyr Glu Ala Phe Thr Phe Leu Lys Gly 
    290                 295                 300                 


Leu Gly Ala Val Ile Leu Val His Ala Glu Asn Gly Asp Leu Ile Ala 
305                 310                 315                 320 


Gln Glu Gln Lys Arg Ile Leu Glu Met Gly Ile Thr Gly Pro Glu Gly 
                325                 330                 335     


His Ala Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg 
            340                 345                 350         


Ala Ile Thr Ile Ala Gly Arg Ile Asn Cys Pro Val Tyr Ile Thr Lys 
        355                 360                 365             


Val Met Ser Lys Ser Ala Ala Asp Ile Ile Ala Leu Ala Arg Lys Lys 
    370                 375                 380                 


Gly Pro Leu Val Phe Gly Glu Pro Ile Ala Ala Ser Leu Gly Thr Asp 
385                 390                 395                 400 


Gly Thr His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val 
                405                 410                 415     


Thr Ser Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Leu Thr 
            420                 425                 430         


Ser Leu Leu Ala Cys Gly Asp Leu Gln Val Thr Gly Ser Gly His Cys 
        435                 440                 445             


Pro Tyr Ser Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu 
    450                 455                 460                 


Ile Pro Glu Gly Val Asn Gly Ile Glu Glu Arg Met Thr Val Val Trp 
465                 470                 475                 480 


Asp Lys Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala 
                485                 490                 495     


Val Thr Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys 
            500                 505                 510         


Gly Arg Ile Ala Val Gly Ser Asp Ala Asp Val Val Ile Trp Asp Pro 
        515                 520                 525             


Asp Lys Leu Lys Thr Ile Thr Ala Lys Ser His Lys Ser Ala Val Glu 
    530                 535                 540                 


Tyr Asn Ile Phe Glu Gly Met Glu Cys His Gly Ser Pro Leu Val Val 
545                 550                 555                 560 


Ile Ser Gln Gly Lys Ile Val Phe Glu Asp Gly Asn Ile Asn Val Asn 
                565                 570                 575     


Lys Gly Met Gly Arg Phe Ile Pro Arg Lys Ala Phe Pro Glu His Leu 
            580                 585                 590         


Tyr Gln Arg Val Lys Ile Arg Asn Lys Val Phe Gly Leu Gln Gly Val 
        595                 600                 605             


Ser Arg Gly Met Tyr Asp Gly Pro Val Tyr Glu Val Pro Ala Thr Pro 
    610                 615                 620                 


Lys Tyr Ala Thr Pro Ala Pro Ser Ala Lys Ser Ser Pro Ser Lys His 
625                 630                 635                 640 


Gln Pro Pro Pro Ile Arg Asn Leu His Gln Ser Asn Phe Ser Leu Ser 
                645                 650                 655     


Gly Ala Gln Ile Asp Asp Asn Asn Pro Arg Arg Thr Gly His Arg Ile 
            660                 665                 670         


Val Ala Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Gly 
        675                 680                 685     


<210>  2599
<211>  836
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRNKL1__Homo_sapiens__NP_001265554

<400>  2599

Met Thr Ala Thr Val Glu Asn Leu Thr Phe Gln Lys Asp Thr Leu Gly 
1               5                   10                  15      


Asn Ala Val Asp Lys Asn Arg Arg His Gly Ser Thr Glu Pro Leu Val 
            20                  25                  30          


Leu Ala Trp Ser Ser Gln Phe Arg Arg Leu Thr Trp Gly Cys Ala Leu 
        35                  40                  45              


Asp Ala Leu His Arg Ser Pro Cys Val Ala Ala Ser Gln His Gly Val 
    50                  55                  60                  


Thr His Leu Ile Arg Ser Ser Arg Thr Pro His Ser Thr Arg Cys Arg 
65                  70                  75                  80  


Lys Glu Asp Ala Gln Pro Gly His His Gly Asn Gly Ala Ala Ser Val 
                85                  90                  95      


Thr Ala Gln Ala Arg Gly Gln Arg Ser Val Leu Gln Val Pro Leu Pro 
            100                 105                 110         


Val Pro Arg Ser Cys Leu Phe Ser Glu Ser Phe Val Val Ser Val Ser 
        115                 120                 125             


Ser Gln Ser Arg Phe Leu Ala Ser Val Pro Gly Thr Gly Val Gln Arg 
    130                 135                 140                 


Ser Thr Ala Ala Asp Met Ala Ala Ser Thr Ala Ala Gly Lys Gln Arg 
145                 150                 155                 160 


Ile Pro Lys Val Ala Lys Val Lys Asn Lys Ala Pro Ala Glu Val Gln 
                165                 170                 175     


Ile Thr Ala Glu Gln Leu Leu Arg Glu Ala Lys Glu Arg Glu Leu Glu 
            180                 185                 190         


Leu Leu Pro Pro Pro Pro Gln Gln Lys Ile Thr Asp Glu Glu Glu Leu 
        195                 200                 205             


Asn Asp Tyr Lys Leu Arg Lys Arg Lys Thr Phe Glu Asp Asn Ile Arg 
    210                 215                 220                 


Lys Asn Arg Thr Val Ile Ser Asn Trp Ile Lys Tyr Ala Gln Trp Glu 
225                 230                 235                 240 


Glu Ser Leu Lys Glu Ile Gln Arg Ala Arg Ser Ile Tyr Glu Arg Ala 
                245                 250                 255     


Leu Asp Val Asp Tyr Arg Asn Ile Thr Leu Trp Leu Lys Tyr Ala Glu 
            260                 265                 270         


Met Glu Met Lys Asn Arg Gln Val Asn His Ala Arg Asn Ile Trp Asp 
        275                 280                 285             


Arg Ala Ile Thr Thr Leu Pro Arg Val Asn Gln Phe Trp Tyr Lys Tyr 
    290                 295                 300                 


Thr Tyr Met Glu Glu Met Leu Gly Asn Val Ala Gly Ala Arg Gln Val 
305                 310                 315                 320 


Phe Glu Arg Trp Met Glu Trp Gln Pro Glu Glu Gln Ala Trp His Ser 
                325                 330                 335     


Tyr Ile Asn Phe Glu Leu Arg Tyr Lys Glu Val Asp Arg Ala Arg Thr 
            340                 345                 350         


Ile Tyr Glu Arg Phe Val Leu Val His Pro Asp Val Lys Asn Trp Ile 
        355                 360                 365             


Lys Tyr Ala Arg Phe Glu Glu Lys His Ala Tyr Phe Ala His Ala Arg 
    370                 375                 380                 


Lys Val Tyr Glu Arg Ala Val Glu Phe Phe Gly Asp Glu His Met Asp 
385                 390                 395                 400 


Glu His Leu Tyr Val Ala Phe Ala Lys Phe Glu Glu Asn Gln Lys Glu 
                405                 410                 415     


Phe Glu Arg Val Arg Val Ile Tyr Lys Tyr Ala Leu Asp Arg Ile Ser 
            420                 425                 430         


Lys Gln Asp Ala Gln Glu Leu Phe Lys Asn Tyr Thr Ile Phe Glu Lys 
        435                 440                 445             


Lys Phe Gly Asp Arg Arg Gly Ile Glu Asp Ile Ile Val Ser Lys Arg 
    450                 455                 460                 


Arg Phe Gln Tyr Glu Glu Glu Val Lys Ala Asn Pro His Asn Tyr Asp 
465                 470                 475                 480 


Ala Trp Phe Asp Tyr Leu Arg Leu Val Glu Ser Asp Ala Glu Ala Glu 
                485                 490                 495     


Ala Val Arg Glu Val Tyr Glu Arg Ala Ile Ala Asn Val Pro Pro Ile 
            500                 505                 510         


Gln Glu Lys Arg His Trp Lys Arg Tyr Ile Tyr Leu Trp Ile Asn Tyr 
        515                 520                 525             


Ala Leu Tyr Glu Glu Leu Glu Ala Lys Asp Pro Glu Arg Thr Arg Gln 
    530                 535                 540                 


Val Tyr Gln Ala Ser Leu Glu Leu Ile Pro His Lys Lys Phe Thr Phe 
545                 550                 555                 560 


Ala Lys Met Trp Ile Leu Tyr Ala Gln Phe Glu Ile Arg Gln Lys Asn 
                565                 570                 575     


Leu Ser Leu Ala Arg Arg Ala Leu Gly Thr Ser Ile Gly Lys Cys Pro 
            580                 585                 590         


Lys Asn Lys Leu Phe Lys Val Tyr Ile Glu Leu Glu Leu Gln Leu Arg 
        595                 600                 605             


Glu Phe Asp Arg Cys Arg Lys Leu Tyr Glu Lys Phe Leu Glu Phe Gly 
    610                 615                 620                 


Pro Glu Asn Cys Thr Ser Trp Ile Lys Phe Ala Glu Leu Glu Thr Ile 
625                 630                 635                 640 


Leu Gly Asp Ile Asp Arg Ala Arg Ala Ile Tyr Glu Leu Ala Ile Ser 
                645                 650                 655     


Gln Pro Arg Leu Asp Met Pro Glu Val Leu Trp Lys Ser Tyr Ile Asp 
            660                 665                 670         


Phe Glu Ile Glu Gln Glu Glu Thr Glu Arg Thr Arg Asn Leu Tyr Arg 
        675                 680                 685             


Arg Leu Leu Gln Arg Thr Gln His Val Lys Val Trp Ile Ser Phe Ala 
    690                 695                 700                 


Gln Phe Glu Leu Ser Ser Gly Lys Glu Gly Ser Leu Thr Lys Cys Arg 
705                 710                 715                 720 


Gln Ile Tyr Glu Glu Ala Asn Lys Thr Met Arg Asn Cys Glu Glu Lys 
                725                 730                 735     


Glu Glu Arg Leu Met Leu Leu Glu Ser Trp Arg Ser Phe Glu Glu Glu 
            740                 745                 750         


Phe Gly Thr Ala Ser Asp Lys Glu Arg Val Asp Lys Leu Met Pro Glu 
        755                 760                 765             


Lys Val Lys Lys Arg Arg Lys Val Gln Thr Asp Asp Gly Ser Asp Ala 
    770                 775                 780                 


Gly Trp Glu Glu Tyr Phe Asp Tyr Ile Phe Pro Glu Asp Ala Ala Asn 
785                 790                 795                 800 


Gln Pro Asn Leu Lys Leu Leu Ala Met Ala Lys Leu Trp Lys Lys Gln 
                805                 810                 815     


Gln Gln Glu Lys Glu Asp Ala Glu His His Pro Asp Glu Asp Val Asp 
            820                 825                 830         


Glu Ser Glu Ser 
        835     


<210>  2600
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRNN__Homo_sapiens__NP_057274

<400>  2600

Met Pro Gln Leu Leu Gln Asn Ile Asn Gly Ile Ile Glu Ala Phe Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Thr Glu Gly Asn Cys Thr Ala Leu Thr Arg Gly Glu 
            20                  25                  30          


Leu Lys Arg Leu Leu Glu Gln Glu Phe Ala Asp Val Ile Val Lys Pro 
        35                  40                  45              


His Asp Pro Ala Thr Val Asp Glu Val Leu Arg Leu Leu Asp Glu Asp 
    50                  55                  60                  


His Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
65                  70                  75                  80  


Val Ala Gln Ala Cys Phe Lys Thr Leu Ser Glu Ser Ala Glu Gly Ala 
                85                  90                  95      


Cys Gly Ser Gln Glu Ser Gly Ser Leu His Ser Gly Ala Ser Gln Glu 
            100                 105                 110         


Leu Gly Glu Gly Gln Arg Ser Gly Thr Glu Val Gly Arg Ala Gly Lys 
        115                 120                 125             


Gly Gln His Tyr Glu Gly Ser Ser His Arg Gln Ser Gln Gln Gly Ser 
    130                 135                 140                 


Arg Gly Gln Asn Arg Pro Gly Val Gln Thr Gln Gly Gln Ala Thr Gly 
145                 150                 155                 160 


Ser Ala Trp Val Ser Ser Tyr Asp Arg Gln Ala Glu Ser Gln Ser Gln 
                165                 170                 175     


Glu Arg Ile Ser Pro Gln Ile Gln Leu Ser Gly Gln Thr Glu Gln Thr 
            180                 185                 190         


Gln Lys Ala Gly Glu Gly Lys Arg Asn Gln Thr Thr Glu Met Arg Pro 
        195                 200                 205             


Glu Arg Gln Pro Gln Thr Arg Glu Gln Asp Arg Ala His Gln Thr Gly 
    210                 215                 220                 


Glu Thr Val Thr Gly Ser Gly Thr Gln Thr Gln Ala Gly Ala Thr Gln 
225                 230                 235                 240 


Thr Val Glu Gln Asp Ser Ser His Gln Thr Gly Arg Thr Ser Lys Gln 
                245                 250                 255     


Thr Gln Glu Ala Thr Asn Asp Gln Asn Arg Gly Thr Glu Thr His Gly 
            260                 265                 270         


Gln Gly Arg Ser Gln Thr Ser Gln Ala Val Thr Gly Gly His Ala Gln 
        275                 280                 285             


Ile Gln Ala Gly Thr His Thr Gln Thr Pro Thr Gln Thr Val Glu Gln 
    290                 295                 300                 


Asp Ser Ser His Gln Thr Gly Ser Thr Ser Thr Gln Thr Gln Glu Ser 
305                 310                 315                 320 


Thr Asn Gly Gln Asn Arg Gly Thr Glu Ile His Gly Gln Gly Arg Ser 
                325                 330                 335     


Gln Thr Ser Gln Ala Val Thr Gly Gly His Thr Gln Ile Gln Ala Gly 
            340                 345                 350         


Ser His Thr Glu Thr Val Glu Gln Asp Arg Ser Gln Thr Val Ser His 
        355                 360                 365             


Gly Gly Ala Arg Glu Gln Gly Gln Thr Gln Thr Gln Pro Gly Ser Gly 
    370                 375                 380                 


Gln Arg Trp Met Gln Val Ser Asn Pro Glu Ala Gly Glu Thr Val Pro 
385                 390                 395                 400 


Gly Gly Gln Ala Gln Thr Gly Ala Ser Thr Glu Ser Gly Arg Gln Glu 
                405                 410                 415     


Trp Ser Ser Thr His Pro Arg Arg Cys Val Thr Glu Gly Gln Gly Asp 
            420                 425                 430         


Arg Gln Pro Thr Val Val Gly Glu Glu Trp Val Asp Asp His Ser Arg 
        435                 440                 445             


Glu Thr Val Ile Leu Arg Leu Asp Gln Gly Asn Leu His Thr Ser Val 
    450                 455                 460                 


Ser Ser Ala Gln Gly Gln Asp Ala Ala Gln Ser Glu Glu Lys Arg Gly 
465                 470                 475                 480 


Ile Thr Ala Arg Glu Leu Tyr Ser Tyr Leu Arg Ser Thr Lys Pro 
                485                 490                 495 


<210>  2601
<211>  1771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CROCC__Homo_sapiens__XP_011540774

<400>  2601

Met Thr Ser Trp Asp Pro Gln Asn Pro Ala Gly Leu Trp Gly Arg Thr 
1               5                   10                  15      


Leu Gly Met Glu Pro Arg Thr Leu Glu Ser Ser Val Leu Cys Gln Glu 
            20                  25                  30          


Lys Gly Leu Gly Ala Arg Asp Leu Ala Gln Asp Ala Gln Ile Thr Ser 
        35                  40                  45              


Leu Pro Ala Leu Ile Arg Glu Ile Val Thr Arg Asn Leu Ser Gln Pro 
    50                  55                  60                  


Glu Ser Pro Val Leu Leu Pro Ala Thr Glu Met Ala Ser Leu Leu Ser 
65                  70                  75                  80  


Leu Gln Glu Glu Asn Gln Leu Leu Gln Gln Glu Leu Ser Arg Val Glu 
                85                  90                  95      


Asp Leu Leu Ala Gln Ser Arg Ala Glu Arg Asp Glu Leu Ala Ile Lys 
            100                 105                 110         


Tyr Asn Ala Val Ser Glu Arg Leu Glu Gln Ala Leu Arg Leu Glu Pro 
        115                 120                 125             


Gly Glu Leu Glu Thr Gln Glu Pro Arg Gly Leu Val Arg Gln Ser Val 
    130                 135                 140                 


Glu Leu Arg Arg Gln Leu Gln Glu Glu Gln Ala Ser Tyr Arg Arg Lys 
145                 150                 155                 160 


Leu Gln Ala Tyr Gln Glu Gly Gln Gln Arg Gln Ala Gln Leu Val Gln 
                165                 170                 175     


Arg Leu Gln Gly Lys Ile Leu Gln Tyr Lys Lys Arg Cys Ser Glu Leu 
            180                 185                 190         


Glu Gln Gln Leu Leu Glu Arg Ser Gly Glu Leu Glu Gln Gln Arg Leu 
        195                 200                 205             


Arg Asp Thr Glu His Ser Gln Asp Leu Glu Ser Ala Leu Ile Arg Leu 
    210                 215                 220                 


Glu Glu Glu Gln Gln Arg Ser Ala Ser Leu Ala Gln Val Asn Ala Met 
225                 230                 235                 240 


Leu Arg Glu Gln Leu Asp Gln Ala Gly Ser Ala Asn Gln Ala Leu Ser 
                245                 250                 255     


Glu Asp Ile Arg Lys Val Thr Asn Asp Trp Thr Arg Cys Arg Lys Glu 
            260                 265                 270         


Leu Glu His Arg Glu Ala Ala Trp Arg Arg Glu Glu Glu Ser Phe Asn 
        275                 280                 285             


Ala Tyr Phe Ser Asn Glu His Ser Arg Leu Leu Leu Leu Trp Arg Gln 
    290                 295                 300                 


Val Val Gly Phe Arg Arg Leu Val Ser Glu Val Lys Met Phe Thr Glu 
305                 310                 315                 320 


Arg Asp Leu Leu Gln Leu Gly Gly Glu Leu Ala Arg Thr Ser Arg Ala 
                325                 330                 335     


Val Gln Glu Ala Gly Leu Gly Leu Ser Thr Gly Leu Arg Leu Ala Glu 
            340                 345                 350         


Ser Arg Ala Glu Ala Ala Leu Glu Lys Gln Ala Leu Leu Gln Ala Gln 
        355                 360                 365             


Leu Glu Glu Gln Leu Arg Asp Lys Val Leu Arg Glu Lys Asp Leu Ala 
    370                 375                 380                 


Gln Gln Gln Met Gln Ser Asp Leu Asp Lys Ala Asp Leu Ser Ala Arg 
385                 390                 395                 400 


Val Thr Glu Leu Gly Leu Ala Val Lys Arg Leu Glu Lys Gln Asn Leu 
                405                 410                 415     


Glu Lys Asp Gln Val Asn Lys Asp Leu Thr Glu Lys Leu Glu Ala Leu 
            420                 425                 430         


Glu Ser Leu Arg Leu Gln Glu Gln Ala Ala Leu Glu Thr Glu Asp Gly 
        435                 440                 445             


Glu Gly Leu Gln Gln Thr Leu Arg Asp Leu Ala Gln Ala Val Leu Ser 
    450                 455                 460                 


Asp Ser Glu Ser Gly Val Gln Leu Ser Gly Ser Glu Arg Thr Ala Asp 
465                 470                 475                 480 


Ala Ser Asn Gly Ser Leu Arg Gly Leu Ser Gly Gln Arg Thr Pro Ser 
                485                 490                 495     


Pro Pro Arg Arg Ser Ser Pro Gly Arg Gly Arg Ser Pro Arg Arg Gly 
            500                 505                 510         


Pro Ser Pro Ala Cys Ser Asp Ser Ser Thr Leu Ala Leu Ile His Ser 
        515                 520                 525             


Ala Leu His Lys Arg Gln Leu Gln Val Gln Asp Met Arg Gly Arg Tyr 
    530                 535                 540                 


Glu Ala Ser Gln Asp Leu Leu Gly Thr Leu Arg Lys Gln Leu Ser Asp 
545                 550                 555                 560 


Ser Glu Ser Glu Arg Arg Ala Leu Glu Glu Gln Leu Gln Arg Leu Arg 
                565                 570                 575     


Asp Lys Thr Asp Gly Ala Met Gln Ala His Glu Asp Ala Gln Arg Glu 
            580                 585                 590         


Val Gln Arg Leu Arg Ser Ala Asn Glu Leu Leu Ser Arg Glu Lys Ser 
        595                 600                 605             


Asn Leu Ala His Ser Leu Gln Val Ala Gln Gln Gln Ala Glu Glu Leu 
    610                 615                 620                 


Arg Gln Glu Arg Glu Lys Leu Gln Ala Ala Gln Glu Glu Leu Arg Arg 
625                 630                 635                 640 


Gln Arg Asp Arg Leu Glu Glu Glu Gln Glu Asp Ala Val Gln Asp Gly 
                645                 650                 655     


Ala Arg Val Arg Arg Glu Leu Glu Arg Ser His Arg Gln Leu Glu Gln 
            660                 665                 670         


Leu Glu Gly Lys Arg Ser Val Leu Ala Lys Glu Leu Val Glu Val Arg 
        675                 680                 685             


Glu Ala Leu Ser Arg Ala Thr Leu Gln Arg Asp Met Leu Gln Ala Glu 
    690                 695                 700                 


Lys Ala Glu Val Ala Glu Ala Leu Thr Lys Ala Glu Ala Gly Arg Val 
705                 710                 715                 720 


Glu Leu Glu Leu Ser Met Thr Lys Leu Arg Ala Glu Glu Ala Ser Leu 
                725                 730                 735     


Gln Asp Ser Leu Ser Lys Leu Ser Ala Leu Asn Glu Ser Leu Ala Gln 
            740                 745                 750         


Asp Lys Leu Asp Leu Asn Arg Leu Val Ala Gln Leu Glu Glu Glu Lys 
        755                 760                 765             


Ser Ala Leu Gln Gly Arg Gln Arg Gln Ala Glu Gln Glu Ala Thr Val 
    770                 775                 780                 


Ala Arg Glu Glu Gln Glu Arg Leu Glu Glu Leu Arg Leu Glu Gln Glu 
785                 790                 795                 800 


Val Ala Arg Gln Gly Leu Glu Gly Ser Leu Arg Val Ala Glu Gln Ala 
                805                 810                 815     


Gln Glu Ala Leu Glu Gln Gln Leu Pro Thr Leu Arg His Glu Arg Ser 
            820                 825                 830         


Gln Leu Gln Glu Gln Leu Ala Gln Leu Ser Arg Gln Leu Ser Gly Arg 
        835                 840                 845             


Glu Gln Glu Leu Glu Gln Ala Arg Arg Glu Ala Gln Arg Gln Val Glu 
    850                 855                 860                 


Ala Leu Glu Arg Ala Ala Arg Glu Lys Glu Ala Leu Ala Lys Glu His 
865                 870                 875                 880 


Ala Gly Leu Ala Val Gln Leu Val Ala Ala Glu Arg Glu Gly Arg Thr 
                885                 890                 895     


Leu Ser Glu Glu Ala Thr Arg Leu Arg Leu Glu Lys Glu Ala Leu Glu 
            900                 905                 910         


Gly Ser Leu Phe Glu Val Gln Arg Gln Leu Ala Gln Leu Glu Ala Arg 
        915                 920                 925             


Arg Glu Gln Leu Glu Ala Glu Gly Gln Ala Leu Leu Leu Ala Lys Glu 
    930                 935                 940                 


Thr Leu Thr Gly Glu Leu Ala Gly Leu Arg Gln Gln Ile Ile Ala Thr 
945                 950                 955                 960 


Gln Glu Lys Ala Ser Leu Asp Lys Glu Leu Met Ala Gln Lys Leu Val 
                965                 970                 975     


Gln Ala Glu Arg Glu Ala Gln Ala Ser Leu Arg Glu Gln Arg Ala Ala 
            980                 985                 990         


His Glu Glu Asp Leu Gln Arg Leu  Gln Arg Glu Lys Glu  Ala Ala Trp 
        995                 1000                 1005             


Arg Glu  Leu Glu Ala Glu Arg  Ala Gln Leu Gln Ser  Gln Leu Gln 
    1010                 1015                 1020             


Arg Glu  Gln Glu Glu Leu Leu  Ala Arg Leu Glu Ala  Glu Lys Glu 
    1025                 1030                 1035             


Glu Leu  Ser Glu Glu Ile Ala  Ala Leu Gln Gln Glu  Arg Asp Glu 
    1040                 1045                 1050             


Gly Leu  Leu Leu Ala Glu Ser  Glu Lys Gln Gln Ala  Leu Ser Leu 
    1055                 1060                 1065             


Lys Glu  Ser Glu Lys Thr Ala  Leu Ser Glu Lys Leu  Met Gly Thr 
    1070                 1075                 1080             


Arg His  Ser Leu Ala Thr Ile  Ser Leu Glu Met Glu  Arg Gln Lys 
    1085                 1090                 1095             


Arg Asp  Ala Gln Ser Arg Gln  Glu Gln Asp Arg Ser  Thr Val Asn 
    1100                 1105                 1110             


Ala Leu  Thr Ser Glu Leu Arg  Asp Leu Arg Ala Gln  Arg Glu Glu 
    1115                 1120                 1125             


Ala Ala  Ala Ala His Ala Gln  Glu Val Arg Arg Leu  Gln Glu Gln 
    1130                 1135                 1140             


Ala Arg  Asp Leu Gly Lys Gln  Arg Asp Ser Cys Leu  Arg Glu Ala 
    1145                 1150                 1155             


Glu Glu  Leu Arg Thr Gln Leu  Arg Leu Leu Glu Asp  Ala Arg Asp 
    1160                 1165                 1170             


Gly Leu  Arg Arg Glu Leu Leu  Glu Ala Gln Arg Lys  Leu Arg Glu 
    1175                 1180                 1185             


Ser Gln  Glu Gly Arg Glu Val  Gln Arg Gln Glu Ala  Gly Glu Leu 
    1190                 1195                 1200             


Arg Arg  Ser Leu Gly Glu Gly  Ala Lys Glu Arg Glu  Ala Leu Arg 
    1205                 1210                 1215             


Arg Ser  Asn Glu Glu Leu Arg  Ser Ala Val Lys Lys  Ala Glu Ser 
    1220                 1225                 1230             


Glu Arg  Ile Ser Leu Lys Leu  Ala Asn Glu Asp Lys  Glu Gln Lys 
    1235                 1240                 1245             


Leu Ala  Leu Leu Glu Glu Ala  Arg Thr Ala Val Gly  Lys Glu Ala 
    1250                 1255                 1260             


Gly Glu  Leu Arg Thr Gly Leu  Gln Glu Val Glu Arg  Ser Arg Leu 
    1265                 1270                 1275             


Glu Ala  Arg Arg Glu Leu Gln  Glu Leu Arg Arg Gln  Met Lys Met 
    1280                 1285                 1290             


Leu Asp  Ser Glu Asn Thr Arg  Leu Gly Arg Glu Leu  Ala Glu Leu 
    1295                 1300                 1305             


Gln Gly  Arg Leu Ala Leu Gly  Glu Arg Ala Glu Lys  Glu Ser Arg 
    1310                 1315                 1320             


Arg Glu  Thr Leu Gly Leu Arg  Gln Arg Leu Leu Lys  Gly Glu Ala 
    1325                 1330                 1335             


Ser Leu  Glu Val Met Arg Gln  Glu Leu Gln Val Ala  Gln Arg Lys 
    1340                 1345                 1350             


Leu Gln  Glu Gln Glu Gly Glu  Phe Arg Thr Arg Glu  Arg Arg Leu 
    1355                 1360                 1365             


Leu Gly  Ser Leu Glu Glu Ala  Arg Gly Thr Glu Lys  Gln Gln Leu 
    1370                 1375                 1380             


Asp His  Ala Arg Gly Leu Glu  Leu Lys Leu Glu Ala  Ala Arg Ala 
    1385                 1390                 1395             


Glu Ala  Ala Glu Leu Gly Leu  Arg Leu Ser Ala Ala  Glu Gly Arg 
    1400                 1405                 1410             


Ala Gln  Gly Leu Glu Ala Glu  Leu Ala Arg Val Glu  Val Gln Arg 
    1415                 1420                 1425             


Arg Ala  Ala Glu Ala Gln Leu  Gly Gly Leu Arg Ser  Ala Leu Arg 
    1430                 1435                 1440             


Arg Gly  Leu Gly Leu Gly Arg  Ala Pro Ser Pro Ala  Pro Arg Pro 
    1445                 1450                 1455             


Val Pro  Gly Ser Pro Ala Arg  Asp Ala Pro Ala Glu  Gly Ser Gly 
    1460                 1465                 1470             


Glu Gly  Leu Asn Ser Pro Ser  Thr Leu Glu Cys Ser  Pro Gly Ser 
    1475                 1480                 1485             


Gln Pro  Pro Ser Pro Gly Pro  Ala Thr Ser Pro Ala  Ser Pro Asp 
    1490                 1495                 1500             


Leu Asp  Pro Glu Ala Val Arg  Gly Ala Leu Arg Glu  Phe Leu Gln 
    1505                 1510                 1515             


Glu Leu  Arg Ser Ala Gln Arg  Glu Arg Asp Glu Leu  Arg Thr Gln 
    1520                 1525                 1530             


Thr Ser  Ala Leu Asn Arg Gln  Leu Ala Glu Met Glu  Ala Glu Arg 
    1535                 1540                 1545             


Asp Ser  Ala Thr Ser Arg Ala  Arg Gln Leu Gln Lys  Ala Val Ala 
    1550                 1555                 1560             


Glu Ser  Glu Glu Ala Arg Arg  Ser Val Asp Gly Arg  Leu Ser Gly 
    1565                 1570                 1575             


Val Gln  Ala Glu Leu Ala Leu  Gln Glu Glu Ser Val  Arg Arg Ser 
    1580                 1585                 1590             


Glu Arg  Glu Arg Arg Ala Thr  Leu Asp Gln Val Ala  Thr Leu Glu 
    1595                 1600                 1605             


Arg Ser  Leu Gln Ala Thr Glu  Ser Glu Leu Arg Ala  Ser Gln Glu 
    1610                 1615                 1620             


Lys Ile  Ser Lys Met Lys Ala  Asn Glu Thr Lys Leu  Glu Gly Asp 
    1625                 1630                 1635             


Lys Arg  Arg Leu Lys Glu Val  Leu Asp Ala Ser Glu  Ser Arg Thr 
    1640                 1645                 1650             


Val Lys  Leu Glu Leu Gln Arg  Arg Ser Leu Glu Gly  Glu Leu Gln 
    1655                 1660                 1665             


Arg Ser  Arg Leu Gly Leu Ser  Asp Arg Glu Ala Gln  Ala Gln Ala 
    1670                 1675                 1680             


Leu Gln  Asp Arg Val Asp Ser  Leu Gln Arg Gln Val  Ala Asp Ser 
    1685                 1690                 1695             


Glu Val  Lys Ala Gly Thr Leu  Gln Leu Thr Val Glu  Arg Leu Asn 
    1700                 1705                 1710             


Gly Ala  Leu Ala Lys Val Glu  Glu Ser Glu Gly Ala  Leu Arg Asp 
    1715                 1720                 1725             


Lys Val  Arg Gly Leu Thr Glu  Ala Leu Ala Gln Ser  Ser Ala Ser 
    1730                 1735                 1740             


Leu Asn  Ser Thr Arg Asp Lys  Asn Leu His Leu Gln  Lys Ala Leu 
    1745                 1750                 1755             


Thr Ala  Cys Glu His Asp Arg  Gln Val Leu Gln Val  Arg 
    1760                 1765                 1770     


<210>  2602
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CROT__Homo_sapiens__NP_001137407

<400>  2602

Met Glu Asn Gln Leu Ala Lys Ser Thr Glu Glu Arg Thr Phe Gln Tyr 
1               5                   10                  15      


Gln Asp Ser Leu Pro Ser Leu Pro Val Pro Ser Leu Glu Glu Ser Leu 
            20                  25                  30          


Lys Lys Tyr Leu Glu Ser Val Thr Arg Thr Cys Tyr Gln Ile Arg Gly 
        35                  40                  45              


Leu Asp Pro Asp Ala Lys Arg Gly Phe Leu Asp Leu Thr Arg Glu Gly 
    50                  55                  60                  


Ile Gln Val Lys Pro Phe Ala Asn Gln Glu Glu Tyr Lys Lys Thr Glu 
65                  70                  75                  80  


Glu Ile Val Gln Lys Phe Gln Ser Gly Ile Gly Glu Lys Leu His Gln 
                85                  90                  95      


Lys Leu Leu Glu Arg Ala Lys Gly Lys Arg Asn Trp Leu Glu Glu Trp 
            100                 105                 110         


Trp Leu Asn Val Ala Tyr Leu Asp Val Arg Ile Pro Ser Gln Leu Asn 
        115                 120                 125             


Val Asn Phe Ala Gly Pro Ala Ala His Phe Glu His Tyr Trp Pro Pro 
    130                 135                 140                 


Lys Glu Gly Thr Gln Leu Glu Arg Gly Ser Ile Thr Leu Trp His Asn 
145                 150                 155                 160 


Leu Asn Tyr Trp Gln Leu Leu Arg Lys Glu Lys Val Pro Val His Lys 
                165                 170                 175     


Val Gly Asn Thr Pro Leu Asp Met Asn Gln Phe Arg Met Leu Phe Ser 
            180                 185                 190         


Thr Cys Lys Val Pro Gly Ile Thr Arg Asp Ser Ile Met Asn Tyr Phe 
        195                 200                 205             


Arg Thr Glu Ser Glu Gly Arg Ser Pro Asn His Ile Val Val Leu Cys 
    210                 215                 220                 


Arg Gly Arg Ala Phe Val Phe Asp Val Ile His Glu Gly Cys Leu Val 
225                 230                 235                 240 


Thr Pro Pro Glu Leu Leu Arg Gln Leu Thr Tyr Ile His Lys Lys Cys 
                245                 250                 255     


His Ser Glu Pro Asp Gly Pro Gly Ile Ala Ala Leu Thr Ser Glu Glu 
            260                 265                 270         


Arg Thr Arg Trp Ala Lys Ala Arg Glu Tyr Leu Ile Gly Leu Asp Pro 
        275                 280                 285             


Glu Asn Leu Ala Leu Leu Glu Lys Ile Gln Ser Ser Leu Leu Val Tyr 
    290                 295                 300                 


Ser Met Glu Asp Ser Ser Pro His Val Thr Pro Glu Asp Tyr Ser Glu 
305                 310                 315                 320 


Ile Ile Ala Ala Ile Leu Ile Gly Asp Pro Thr Val Arg Trp Gly Asp 
                325                 330                 335     


Lys Ser Tyr Asn Leu Ile Ser Phe Ser Asn Gly Val Phe Gly Cys Asn 
            340                 345                 350         


Cys Asp His Ala Pro Phe Asp Ala Met Ile Met Val Asn Ile Ser Tyr 
        355                 360                 365             


Tyr Val Asp Glu Lys Ile Phe Gln Asn Glu Gly Arg Trp Lys Gly Ser 
    370                 375                 380                 


Glu Lys Val Arg Asp Ile Pro Leu Pro Glu Glu Leu Ile Phe Ile Val 
385                 390                 395                 400 


Asp Glu Lys Val Leu Asn Asp Ile Asn Gln Ala Lys Ala Gln Tyr Leu 
                405                 410                 415     


Arg Glu Ala Ser Asp Leu Gln Ile Ala Ala Tyr Ala Phe Thr Ser Phe 
            420                 425                 430         


Gly Lys Lys Leu Thr Lys Asn Lys Met Leu His Pro Asp Thr Phe Ile 
        435                 440                 445             


Gln Leu Ala Leu Gln Leu Ala Tyr Tyr Arg Leu His Gly His Pro Gly 
    450                 455                 460                 


Cys Cys Tyr Glu Thr Ala Met Thr Arg His Phe Tyr His Gly Arg Thr 
465                 470                 475                 480 


Glu Thr Met Arg Ser Cys Thr Val Glu Ala Val Arg Trp Cys Gln Ser 
                485                 490                 495     


Met Gln Asp Pro Ser Val Asn Leu Arg Glu Arg Gln Gln Lys Met Leu 
            500                 505                 510         


Gln Ala Phe Ala Lys His Asn Lys Met Met Lys Asp Cys Ser Ala Gly 
        515                 520                 525             


Lys Gly Phe Asp Arg His Leu Leu Gly Leu Leu Leu Ile Ala Lys Glu 
    530                 535                 540                 


Glu Gly Leu Pro Val Pro Glu Leu Phe Thr Asp Pro Leu Phe Ser Lys 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Asn Phe Val Leu Ser Thr Ser Leu Val Gly Tyr 
                565                 570                 575     


Leu Arg Val Gln Gly Val Val Val Pro Met Val His Asn Gly Tyr Gly 
            580                 585                 590         


Phe Phe Tyr His Ile Arg Asp Asp Arg Phe Val Val Ala Cys Ser Ala 
        595                 600                 605             


Trp Lys Ser Cys Pro Glu Thr Asp Ala Glu Lys Leu Val Gln Leu Thr 
    610                 615                 620                 


Phe Cys Ala Phe His Asp Met Ile Gln Leu Met Asn Ser Thr His Leu 
625                 630                 635                 640 


<210>  2603
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRP__Homo_sapiens__XP_011507509

<400>  2603

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210>  2604
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRTAC1__Homo_sapiens__NP_001193457

<400>  2604

Met Ala Pro Ser Ala Asp Pro Gly Met Ser Arg Met Leu Pro Phe Leu 
1               5                   10                  15      


Leu Leu Leu Trp Phe Leu Pro Ile Thr Glu Gly Ser Gln Arg Ala Glu 
            20                  25                  30          


Pro Met Phe Thr Ala Val Thr Asn Ser Val Leu Pro Pro Asp Tyr Asp 
        35                  40                  45              


Ser Asn Pro Thr Gln Leu Asn Tyr Gly Val Ala Val Thr Asp Val Asp 
    50                  55                  60                  


His Asp Gly Asp Phe Glu Ile Val Val Ala Gly Tyr Asn Gly Pro Asn 
65                  70                  75                  80  


Leu Val Leu Lys Tyr Asp Arg Ala Gln Lys Arg Leu Val Asn Ile Ala 
                85                  90                  95      


Val Asp Glu Arg Ser Ser Pro Tyr Tyr Ala Leu Arg Asp Arg Gln Gly 
            100                 105                 110         


Asn Ala Ile Gly Val Thr Ala Cys Asp Ile Asp Gly Asp Gly Arg Glu 
        115                 120                 125             


Glu Ile Tyr Phe Leu Asn Thr Asn Asn Ala Phe Ser Gly Val Ala Thr 
    130                 135                 140                 


Tyr Thr Asp Lys Leu Phe Lys Phe Arg Asn Asn Arg Trp Glu Asp Ile 
145                 150                 155                 160 


Leu Ser Asp Glu Val Asn Val Ala Arg Gly Val Ala Ser Leu Phe Ala 
                165                 170                 175     


Gly Arg Ser Val Ala Cys Val Asp Arg Lys Gly Ser Gly Arg Tyr Ser 
            180                 185                 190         


Ile Tyr Ile Ala Asn Tyr Ala Tyr Gly Asn Val Gly Pro Asp Ala Leu 
        195                 200                 205             


Ile Glu Met Asp Pro Glu Ala Ser Asp Leu Ser Arg Gly Ile Leu Ala 
    210                 215                 220                 


Leu Arg Asp Val Ala Ala Glu Ala Gly Val Ser Lys Tyr Thr Gly Gly 
225                 230                 235                 240 


Arg Gly Val Ser Val Gly Pro Ile Leu Ser Ser Ser Ala Ser Asp Ile 
                245                 250                 255     


Phe Cys Asp Asn Glu Asn Gly Pro Asn Phe Leu Phe His Asn Arg Gly 
            260                 265                 270         


Asp Gly Thr Phe Val Asp Ala Ala Ala Ser Ala Gly Val Asp Asp Pro 
        275                 280                 285             


His Gln His Gly Arg Gly Val Ala Leu Ala Asp Phe Asn Arg Asp Gly 
    290                 295                 300                 


Lys Val Asp Ile Val Tyr Gly Asn Trp Asn Gly Pro His Arg Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Ser Thr His Gly Lys Val Arg Phe Arg Asp Ile Ala Ser 
                325                 330                 335     


Pro Lys Phe Ser Met Pro Ser Pro Val Arg Thr Val Ile Thr Ala Asp 
            340                 345                 350         


Phe Asp Asn Asp Gln Glu Leu Glu Ile Phe Phe Asn Asn Ile Ala Tyr 
        355                 360                 365             


Arg Ser Ser Ser Ala Asn Arg Leu Phe Arg Val Ile Arg Arg Glu His 
    370                 375                 380                 


Gly Asp Pro Leu Ile Glu Glu Leu Asn Pro Gly Asp Ala Leu Glu Pro 
385                 390                 395                 400 


Glu Gly Arg Gly Thr Gly Gly Val Val Thr Asp Phe Asp Gly Asp Gly 
                405                 410                 415     


Met Leu Asp Leu Ile Leu Ser His Gly Glu Ser Met Ala Gln Pro Leu 
            420                 425                 430         


Ser Val Phe Arg Gly Asn Gln Gly Phe Asn Asn Asn Trp Leu Arg Val 
        435                 440                 445             


Val Pro Arg Thr Arg Phe Gly Ala Phe Ala Arg Gly Ala Lys Val Val 
    450                 455                 460                 


Leu Tyr Thr Lys Lys Ser Gly Ala His Leu Arg Ile Ile Asp Gly Gly 
465                 470                 475                 480 


Ser Gly Tyr Leu Cys Glu Met Glu Pro Val Ala His Phe Gly Leu Gly 
                485                 490                 495     


Lys Asp Glu Ala Ser Ser Val Glu Val Thr Trp Pro Asp Gly Lys Met 
            500                 505                 510         


Val Ser Arg Asn Val Ala Ser Gly Glu Met Asn Ser Val Leu Glu Ile 
        515                 520                 525             


Leu Tyr Pro Arg Asp Glu Asp Thr Leu Gln Asp Pro Ala Pro Leu Glu 
    530                 535                 540                 


Cys Gly Gln Gly Phe Ser Gln Gln Glu Asn Gly His Cys Met Asp Thr 
545                 550                 555                 560 


Asn Glu Cys Ile Gln Phe Pro Phe Val Cys Pro Arg Asp Lys Pro Val 
                565                 570                 575     


Cys Val Asn Thr Tyr Gly Ser Tyr Arg Cys Arg Thr Asn Lys Lys Cys 
            580                 585                 590         


Ser Arg Gly Tyr Glu Pro Asn Glu Asp Gly Thr Ala Cys Val Ala Gln 
        595                 600                 605             


Val Ala Phe Leu Gly Gly Tyr Ser Ser Ala Ala Ser Arg Ile Ser Glu 
    610                 615                 620                 


Pro Leu Ser Arg Ala Ser Tyr Leu Ser Leu Gly Leu Gly Leu Cys Leu 
625                 630                 635                 640 


Gln Leu Tyr Ala Leu 
                645 


<210>  2605
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRTAM__Homo_sapiens__NP_001291711

<400>  2605

Met Trp Val Lys Leu Leu Ser Ile Val Ala Glu Phe Cys Phe Ser Pro 
1               5                   10                  15      


Phe Leu Val Thr Asp Glu Glu Thr Ala Ser Asp Ala Leu Glu Arg Asn 
            20                  25                  30          


Ser Leu Ser Ser Gln Asp Pro Gln Gln Pro Thr Ser Thr Val Ser Val 
        35                  40                  45              


Thr Glu Asp Ser Ser Thr Ser Glu Ile Asp Lys Glu Glu Lys Glu Gln 
    50                  55                  60                  


Thr Thr Gln Asp Pro Asp Leu Thr Thr Glu Ala Asn Pro Gln Tyr Leu 
65                  70                  75                  80  


Gly Leu Ala Arg Lys Lys Ser Gly Ile Leu Leu Leu Thr Leu Val Ser 
                85                  90                  95      


Phe Leu Ile Phe Ile Leu Phe Ile Ile Val Gln Leu Phe Ile Met Lys 
            100                 105                 110         


Leu Arg Lys Ala His Val Ile Trp Lys Lys Glu Asn Glu Val Ser Glu 
        115                 120                 125             


His Thr Leu Glu Ser Tyr Arg Ser Arg Ser Asn Asn Glu Glu Thr Ser 
    130                 135                 140                 


Ser Glu Glu Lys Asn Gly Gln Ser Ser His Pro Met Arg Cys Met Asn 
145                 150                 155                 160 


Tyr Ile Thr Lys Leu Tyr Ser Glu Ala Lys Thr Lys Arg Lys Glu Asn 
                165                 170                 175     


Val Gln His Ser Lys Leu Glu Glu Lys His Ile Gln Val Pro Glu Ser 
            180                 185                 190         


Ile Val 
        


<210>  2606
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRTAP__Homo_sapiens__NP_006362

<400>  2606

Met Glu Pro Gly Arg Arg Gly Ala Ala Ala Leu Leu Ala Leu Leu Cys 
1               5                   10                  15      


Val Ala Cys Ala Leu Arg Ala Gly Arg Ala Gln Tyr Glu Arg Tyr Ser 
            20                  25                  30          


Phe Arg Ser Phe Pro Arg Asp Glu Leu Met Pro Leu Glu Ser Ala Tyr 
        35                  40                  45              


Arg His Ala Leu Asp Lys Tyr Ser Gly Glu His Trp Ala Glu Ser Val 
    50                  55                  60                  


Gly Tyr Leu Glu Ile Ser Leu Arg Leu His Arg Leu Leu Arg Asp Ser 
65                  70                  75                  80  


Glu Ala Phe Cys His Arg Asn Cys Ser Ala Ala Pro Gln Pro Glu Pro 
                85                  90                  95      


Ala Ala Gly Leu Ala Ser Tyr Pro Glu Leu Arg Leu Phe Gly Gly Leu 
            100                 105                 110         


Leu Arg Arg Ala His Cys Leu Lys Arg Cys Lys Gln Gly Leu Pro Ala 
        115                 120                 125             


Phe Arg Gln Ser Gln Pro Ser Arg Glu Val Leu Ala Asp Phe Gln Arg 
    130                 135                 140                 


Arg Glu Pro Tyr Lys Phe Leu Gln Phe Ala Tyr Phe Lys Ala Asn Asn 
145                 150                 155                 160 


Leu Pro Lys Ala Ile Ala Ala Ala His Thr Phe Leu Leu Lys His Pro 
                165                 170                 175     


Asp Asp Glu Met Met Lys Arg Asn Met Ala Tyr Tyr Lys Ser Leu Pro 
            180                 185                 190         


Gly Ala Glu Asp Tyr Ile Lys Asp Leu Glu Thr Lys Ser Tyr Glu Ser 
        195                 200                 205             


Leu Phe Ile Arg Ala Val Arg Ala Tyr Asn Gly Glu Asn Trp Arg Thr 
    210                 215                 220                 


Ser Ile Thr Asp Met Glu Leu Ala Leu Pro Asp Phe Phe Lys Ala Phe 
225                 230                 235                 240 


Tyr Glu Cys Leu Ala Ala Cys Glu Gly Ser Arg Glu Ile Lys Asp Phe 
                245                 250                 255     


Lys Asp Phe Tyr Leu Ser Ile Ala Asp His Tyr Val Glu Val Leu Glu 
            260                 265                 270         


Cys Lys Ile Gln Cys Glu Glu Asn Leu Thr Pro Val Ile Gly Gly Tyr 
        275                 280                 285             


Pro Val Glu Lys Phe Val Ala Thr Met Tyr His Tyr Leu Gln Phe Ala 
    290                 295                 300                 


Tyr Tyr Lys Leu Asn Asp Leu Lys Asn Ala Ala Pro Cys Ala Val Ser 
305                 310                 315                 320 


Tyr Leu Leu Phe Asp Gln Asn Asp Lys Val Met Gln Gln Asn Leu Val 
                325                 330                 335     


Tyr Tyr Gln Tyr His Arg Asp Thr Trp Gly Leu Ser Asp Glu His Phe 
            340                 345                 350         


Gln Pro Arg Pro Glu Ala Val Gln Phe Phe Asn Val Thr Thr Leu Gln 
        355                 360                 365             


Lys Glu Leu Tyr Asp Phe Ala Lys Glu Asn Ile Met Asp Asp Asp Glu 
    370                 375                 380                 


Gly Glu Val Val Glu Tyr Val Asp Asp Leu Leu Glu Leu Glu Glu Thr 
385                 390                 395                 400 


Ser 
    


<210>  2607
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRTC1__Homo_sapiens__NP_001091952

<400>  2607

Met Ala Thr Ser Asn Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu 
1               5                   10                  15      


His Asn Gln Lys Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met 
            20                  25                  30          


Lys Asp Leu Ser Leu Thr Arg Ala Ala Arg Leu Gln Leu Gln Lys Ser 
        35                  40                  45              


Gln Tyr Leu Gln Leu Gly Pro Ser Arg Gly Gln Tyr Tyr Gly Gly Ser 
    50                  55                  60                  


Leu Pro Asn Val Asn Gln Ile Gly Ser Gly Thr Met Asp Leu Pro Phe 
65                  70                  75                  80  


Gln Pro Ser Gly Phe Leu Gly Glu Ala Leu Ala Ala Ala Pro Val Ser 
                85                  90                  95      


Leu Thr Pro Phe Gln Ser Ser Gly Leu Asp Thr Ser Arg Thr Thr Arg 
            100                 105                 110         


His His Gly Leu Val Asp Arg Val Tyr Arg Glu Arg Gly Arg Leu Gly 
        115                 120                 125             


Ser Pro His Arg Arg Pro Leu Ser Val Asp Lys His Gly Arg Gln Ala 
    130                 135                 140                 


Asp Ser Cys Pro Tyr Gly Thr Met Tyr Leu Ser Pro Pro Ala Asp Thr 
145                 150                 155                 160 


Ser Trp Arg Arg Thr Asn Ser Asp Ser Ala Leu His Gln Ser Thr Met 
                165                 170                 175     


Thr Pro Thr Gln Pro Glu Ser Phe Ser Ser Gly Ser Gln Asp Val His 
            180                 185                 190         


Gln Lys Arg Val Leu Leu Leu Thr Val Pro Gly Met Glu Glu Thr Thr 
        195                 200                 205             


Ser Glu Ala Asp Lys Asn Leu Ser Lys Gln Ala Trp Asp Thr Lys Lys 
    210                 215                 220                 


Thr Gly Ser Arg Pro Lys Ser Cys Glu Val Pro Gly Ile Asn Ile Phe 
225                 230                 235                 240 


Pro Ser Ala Asp Gln Glu Asn Thr Thr Ala Leu Ile Pro Ala Thr His 
                245                 250                 255     


Asn Thr Gly Gly Ser Leu Pro Asp Leu Thr Asn Ile His Phe Pro Ser 
            260                 265                 270         


Pro Leu Pro Thr Pro Leu Asp Pro Glu Glu Pro Thr Phe Pro Ala Leu 
        275                 280                 285             


Ser Ser Ser Ser Ser Thr Gly Asn Leu Ala Ala Asn Leu Thr His Leu 
    290                 295                 300                 


Gly Ile Gly Gly Ala Gly Gln Gly Met Ser Thr Pro Gly Ser Ser Pro 
305                 310                 315                 320 


Gln His Arg Pro Ala Gly Val Ser Pro Leu Ser Leu Ser Thr Glu Ala 
                325                 330                 335     


Arg Arg Gln Gln Ala Ser Pro Thr Leu Ser Pro Leu Ser Pro Ile Thr 
            340                 345                 350         


Gln Ala Val Ala Met Asp Ala Leu Ser Leu Glu Gln Gln Leu Pro Tyr 
        355                 360                 365             


Ala Phe Phe Thr Gln Ala Gly Ser Gln Gln Pro Pro Pro Gln Pro Gln 
    370                 375                 380                 


Pro Pro Pro Pro Pro Pro Pro Ala Ser Gln Gln Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Gln Ala Pro Val Arg Leu Pro Pro Gly Gly Pro Leu Leu Pro 
                405                 410                 415     


Ser Ala Ser Leu Thr Arg Gly Pro Gln Pro Pro Pro Leu Ala Val Thr 
            420                 425                 430         


Val Pro Ser Ser Leu Pro Gln Ser Pro Pro Glu Asn Pro Gly Gln Pro 
        435                 440                 445             


Ser Met Gly Ile Asp Ile Ala Ser Ala Pro Ala Leu Gln Gln Tyr Arg 
    450                 455                 460                 


Thr Ser Ala Gly Ser Pro Ala Asn Gln Ser Pro Thr Ser Pro Val Ser 
465                 470                 475                 480 


Asn Gln Gly Phe Ser Pro Gly Ser Ser Pro Gln His Thr Ser Thr Leu 
                485                 490                 495     


Gly Ser Val Phe Gly Asp Ala Tyr Tyr Glu Gln Gln Met Ala Ala Arg 
            500                 505                 510         


Gln Ala Asn Ala Leu Ser His Gln Leu Glu Gln Phe Asn Met Met Glu 
        515                 520                 525             


Asn Ala Ile Ser Ser Ser Ser Leu Tyr Ser Pro Gly Ser Thr Leu Asn 
    530                 535                 540                 


Tyr Ser Gln Ala Ala Met Met Gly Leu Thr Gly Ser His Gly Ser Leu 
545                 550                 555                 560 


Pro Asp Ser Gln Gln Leu Gly Tyr Ala Ser His Ser Gly Ile Pro Asn 
                565                 570                 575     


Ile Ile Leu Thr Val Thr Gly Glu Ser Pro Pro Ser Leu Ser Lys Glu 
            580                 585                 590         


Leu Thr Ser Ser Leu Ala Gly Val Gly Asp Val Ser Phe Asp Ser Asp 
        595                 600                 605             


Ser Gln Phe Pro Leu Asp Glu Leu Lys Ile Asp Pro Leu Thr Leu Asp 
    610                 615                 620                 


Gly Leu His Met Leu Asn Asp Pro Asp Met Val Leu Ala Asp Pro Ala 
625                 630                 635                 640 


Thr Glu Asp Thr Phe Arg Met Asp Arg Leu 
                645                 650 


<210>  2608
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRTC2__Homo_sapiens__NP_859066

<400>  2608

Met Ala Thr Ser Gly Ala Asn Gly Pro Gly Ser Ala Thr Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Thr Arg Leu Gln Ala Gln Lys Leu Arg Leu Ala Tyr Thr Arg Ser 
    50                  55                  60                  


Ser His Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Phe Gln Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg 
                85                  90                  95      


Ser Thr Arg His His Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg 
            100                 105                 110         


Arg Met Val Ser Pro Leu Arg Arg Tyr Thr Arg His Ile Asp Ser Ser 
        115                 120                 125             


Pro Tyr Ser Pro Ala Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg 
    130                 135                 140                 


Arg Thr Met Ala Trp Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe 
145                 150                 155                 160 


Arg Leu Pro Ser Ala Leu Asn Arg Thr Ser Ser Asp Ser Ala Leu His 
                165                 170                 175     


Thr Ser Val Met Asn Pro Ser Pro Gln Asp Thr Tyr Pro Gly Pro Thr 
            180                 185                 190         


Pro Pro Ser Ile Leu Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu 
        195                 200                 205             


Met Asp Pro Lys Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    210                 215                 220                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                245                 250                 255     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Thr Gly 
            260                 265                 270         


Gly Ser Leu Pro Asp Leu Thr Asn Leu His Phe Pro Pro Pro Leu Pro 
        275                 280                 285             


Thr Pro Leu Asp Pro Glu Glu Thr Ala Tyr Pro Ser Leu Ser Gly Gly 
    290                 295                 300                 


Asn Ser Thr Ser Asn Leu Thr His Thr Met Thr His Leu Gly Ile Ser 
305                 310                 315                 320 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                325                 330                 335     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            340                 345                 350         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        355                 360                 365             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Thr 
    370                 375                 380                 


Thr Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Thr Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                405                 410                 415     


Pro Ala Ser Thr Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            420                 425                 430         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        435                 440                 445             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Thr Met Ser Pro Thr Leu Ser 
    450                 455                 460                 


Ser Ile Thr Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
465                 470                 475                 480 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                485                 490                 495     


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            500                 505                 510         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        515                 520                 525             


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    530                 535                 540                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                565                 570                 575     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            580                 585                 590         


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
        595                 600                 605             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
    610                 615                 620                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
625                 630                 635                 640 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                645                 650                 655     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            660                 665                 670         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        675                 680                 685             


Ser Asp Arg Leu Gln 
    690             


<210>  2609
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRTC3__Homo_sapiens__NP_001036039

<400>  2609

Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn Pro Arg Lys Phe Ser 
1               5                   10                  15      


Glu Lys Ile Ala Leu His Thr Gln Arg Gln Ala Glu Glu Thr Arg Ala 
            20                  25                  30          


Phe Glu Gln Leu Met Thr Asp Leu Thr Leu Ser Arg Val Gln Phe Gln 
        35                  40                  45              


Lys Leu Gln Gln Leu Arg Leu Thr Gln Tyr His Gly Gly Ser Leu Pro 
    50                  55                  60                  


Asn Val Ser Gln Leu Arg Ser Ser Ala Ser Glu Phe Gln Pro Ser Phe 
65                  70                  75                  80  


His Gln Ala Asp Asn Val Arg Gly Thr Arg His His Gly Leu Val Glu 
                85                  90                  95      


Arg Pro Ser Arg Asn Arg Phe His Pro Leu His Arg Arg Ser Gly Asp 
            100                 105                 110         


Lys Pro Gly Arg Gln Phe Asp Gly Ser Ala Phe Gly Ala Asn Tyr Ser 
        115                 120                 125             


Ser Gln Pro Leu Asp Glu Ser Trp Pro Arg Gln Gln Pro Pro Trp Lys 
    130                 135                 140                 


Asp Glu Lys His Pro Gly Phe Arg Leu Thr Ser Ala Leu Asn Arg Thr 
145                 150                 155                 160 


Asn Ser Asp Ser Ala Leu His Thr Ser Ala Leu Ser Thr Lys Pro Gln 
                165                 170                 175     


Asp Pro Tyr Gly Gly Gly Gly Gln Ser Ala Trp Pro Ala Pro Tyr Met 
            180                 185                 190         


Gly Phe Cys Asp Gly Glu Asn Asn Gly His Gly Glu Val Ala Ser Phe 
        195                 200                 205             


Pro Gly Pro Leu Lys Glu Glu Asn Leu Leu Asn Val Pro Lys Pro Leu 
    210                 215                 220                 


Pro Lys Gln Leu Trp Glu Thr Lys Glu Ile Gln Ser Leu Ser Gly Arg 
225                 230                 235                 240 


Pro Arg Ser Cys Asp Val Gly Gly Gly Asn Ala Phe Pro His Asn Gly 
                245                 250                 255     


Gln Asn Leu Gly Leu Ser Pro Phe Leu Gly Thr Leu Asn Thr Gly Gly 
            260                 265                 270         


Ser Leu Pro Asp Leu Thr Asn Leu His Tyr Ser Thr Pro Leu Pro Ala 
        275                 280                 285             


Ser Leu Asp Thr Thr Asp His His Phe Gly Ser Met Ser Val Gly Asn 
    290                 295                 300                 


Ser Val Asn Asn Ile Pro Ala Ala Met Thr His Leu Gly Ile Arg Ser 
305                 310                 315                 320 


Ser Ser Gly Leu Gln Ser Ser Arg Ser Asn Pro Ser Ile Gln Ala Thr 
                325                 330                 335     


Leu Asn Lys Thr Val Leu Ser Ser Ser Leu Asn Asn His Pro Gln Thr 
            340                 345                 350         


Ser Val Pro Asn Ala Ser Ala Leu His Pro Ser Leu Arg Leu Phe Ser 
        355                 360                 365             


Leu Ser Asn Pro Ser Leu Ser Thr Thr Asn Leu Ser Gly Pro Ser Arg 
    370                 375                 380                 


Arg Arg Gln Pro Pro Val Ser Pro Leu Thr Leu Ser Pro Gly Pro Glu 
385                 390                 395                 400 


Ala His Gln Gly Phe Ser Arg Gln Leu Ser Ser Thr Ser Pro Leu Ala 
                405                 410                 415     


Pro Tyr Pro Thr Ser Gln Met Val Ser Ser Asp Arg Ser Gln Leu Ser 
            420                 425                 430         


Phe Leu Pro Thr Glu Ala Gln Ala Gln Val Ser Pro Pro Pro Pro Tyr 
        435                 440                 445             


Pro Ala Pro Gln Glu Leu Thr Gln Pro Leu Leu Gln Gln Pro Arg Ala 
    450                 455                 460                 


Pro Glu Ala Pro Ala Gln Gln Pro Gln Ala Ala Ser Ser Leu Pro Gln 
465                 470                 475                 480 


Ser Asp Phe Gln Leu Leu Pro Ala Gln Gly Ser Ser Leu Thr Asn Phe 
                485                 490                 495     


Phe Pro Asp Val Gly Phe Asp Gln Gln Ser Met Arg Pro Gly Pro Ala 
            500                 505                 510         


Phe Pro Gln Gln Val Pro Leu Val Gln Gln Gly Ser Arg Glu Leu Gln 
        515                 520                 525             


Asp Ser Phe His Leu Arg Pro Ser Pro Tyr Ser Asn Cys Gly Ser Leu 
    530                 535                 540                 


Pro Asn Thr Ile Leu Pro Asp Ser Ser Thr Ser Leu Phe Lys Asp Leu 
545                 550                 555                 560 


Asn Ser Ala Leu Ala Gly Leu Pro Glu Val Ser Leu Asn Val Asp Thr 
                565                 570                 575     


Pro Phe Pro Leu Glu Glu Glu Leu Gln Ile Glu Pro Leu Ser Leu Asp 
            580                 585                 590         


Gly Leu Asn Met Leu Ser Asp Ser Ser Met Gly Leu Leu Asp Pro Ser 
        595                 600                 605             


Val Glu Glu Thr Phe Arg Ala Asp Arg Leu 
    610                 615             


<210>  2610
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRX__Homo_sapiens__NP_000545

<400>  2610

Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg 
        35                  40                  45              


Ser Gln Leu Glu Glu Leu Glu Ala Leu Phe Ala Lys Thr Gln Tyr Pro 
    50                  55                  60                  


Asp Val Tyr Ala Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu 
65                  70                  75                  80  


Ser Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln 
                85                  90                  95      


Gln Arg Gln Gln Gln Lys Gln Gln Gln Gln Pro Pro Gly Gly Gln Ala 
            100                 105                 110         


Lys Ala Arg Pro Ala Lys Arg Lys Ala Gly Thr Ser Pro Arg Pro Ser 
        115                 120                 125             


Thr Asp Val Cys Pro Asp Pro Leu Gly Ile Ser Asp Ser Tyr Ser Pro 
    130                 135                 140                 


Pro Leu Pro Gly Pro Ser Gly Ser Pro Thr Thr Ala Val Ala Thr Val 
145                 150                 155                 160 


Ser Ile Trp Ser Pro Ala Ser Glu Ser Pro Leu Pro Glu Ala Gln Arg 
                165                 170                 175     


Ala Gly Leu Val Ala Ser Gly Pro Ser Leu Thr Ser Ala Pro Tyr Ala 
            180                 185                 190         


Met Thr Tyr Ala Pro Ala Ser Ala Phe Cys Ser Ser Pro Ser Ala Tyr 
        195                 200                 205             


Gly Ser Pro Ser Ser Tyr Phe Ser Gly Leu Asp Pro Tyr Leu Ser Pro 
    210                 215                 220                 


Met Val Pro Gln Leu Gly Gly Pro Ala Leu Ser Pro Leu Ser Gly Pro 
225                 230                 235                 240 


Ser Val Gly Pro Ser Leu Ala Gln Ser Pro Thr Ser Leu Ser Gly Gln 
                245                 250                 255     


Ser Tyr Gly Ala Tyr Ser Pro Val Asp Ser Leu Glu Phe Lys Asp Pro 
            260                 265                 270         


Thr Gly Thr Trp Lys Phe Thr Tyr Asn Pro Met Asp Pro Leu Asp Tyr 
        275                 280                 285             


Lys Asp Gln Ser Ala Trp Lys Phe Gln Ile Leu 
    290                 295                 


<210>  2611
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRY1__Homo_sapiens__NP_004066

<400>  2611

Met Gly Val Asn Ala Val His Trp Phe Arg Lys Gly Leu Arg Leu His 
1               5                   10                  15      


Asp Asn Pro Ala Leu Lys Glu Cys Ile Gln Gly Ala Asp Thr Ile Arg 
            20                  25                  30          


Cys Val Tyr Ile Leu Asp Pro Trp Phe Ala Gly Ser Ser Asn Val Gly 
        35                  40                  45              


Ile Asn Arg Trp Arg Phe Leu Leu Gln Cys Leu Glu Asp Leu Asp Ala 
    50                  55                  60                  


Asn Leu Arg Lys Leu Asn Ser Arg Leu Phe Val Ile Arg Gly Gln Pro 
65                  70                  75                  80  


Ala Asp Val Phe Pro Arg Leu Phe Lys Glu Trp Asn Ile Thr Lys Leu 
                85                  90                  95      


Ser Ile Glu Tyr Asp Ser Glu Pro Phe Gly Lys Glu Arg Asp Ala Ala 
            100                 105                 110         


Ile Lys Lys Leu Ala Thr Glu Ala Gly Val Glu Val Ile Val Arg Ile 
        115                 120                 125             


Ser His Thr Leu Tyr Asp Leu Asp Lys Ile Ile Glu Leu Asn Gly Gly 
    130                 135                 140                 


Gln Pro Pro Leu Thr Tyr Lys Arg Phe Gln Thr Leu Ile Ser Lys Met 
145                 150                 155                 160 


Glu Pro Leu Glu Ile Pro Val Glu Thr Ile Thr Ser Glu Val Ile Glu 
                165                 170                 175     


Lys Cys Thr Thr Pro Leu Ser Asp Asp His Asp Glu Lys Tyr Gly Val 
            180                 185                 190         


Pro Ser Leu Glu Glu Leu Gly Phe Asp Thr Asp Gly Leu Ser Ser Ala 
        195                 200                 205             


Val Trp Pro Gly Gly Glu Thr Glu Ala Leu Thr Arg Leu Glu Arg His 
    210                 215                 220                 


Leu Glu Arg Lys Ala Trp Val Ala Asn Phe Glu Arg Pro Arg Met Asn 
225                 230                 235                 240 


Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly Leu Ser Pro Tyr Leu Arg 
                245                 250                 255     


Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr Phe Lys Leu Thr Asp Leu 
            260                 265                 270         


Tyr Lys Lys Val Lys Lys Asn Ser Ser Pro Pro Leu Ser Leu Tyr Gly 
        275                 280                 285             


Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr Ala Ala Thr Asn Asn Pro 
    290                 295                 300                 


Arg Phe Asp Lys Met Glu Gly Asn Pro Ile Cys Val Gln Ile Pro Trp 
305                 310                 315                 320 


Asp Lys Asn Pro Glu Ala Leu Ala Lys Trp Ala Glu Gly Arg Thr Gly 
                325                 330                 335     


Phe Pro Trp Ile Asp Ala Ile Met Thr Gln Leu Arg Gln Glu Gly Trp 
            340                 345                 350         


Ile His His Leu Ala Arg His Ala Val Ala Cys Phe Leu Thr Arg Gly 
        355                 360                 365             


Asp Leu Trp Ile Ser Trp Glu Glu Gly Met Lys Val Phe Glu Glu Leu 
    370                 375                 380                 


Leu Leu Asp Ala Asp Trp Ser Ile Asn Ala Gly Ser Trp Met Trp Leu 
385                 390                 395                 400 


Ser Cys Ser Ser Phe Phe Gln Gln Phe Phe His Cys Tyr Cys Pro Val 
                405                 410                 415     


Gly Phe Gly Arg Arg Thr Asp Pro Asn Gly Asp Tyr Ile Arg Arg Tyr 
            420                 425                 430         


Leu Pro Val Leu Arg Gly Phe Pro Ala Lys Tyr Ile Tyr Asp Pro Trp 
        435                 440                 445             


Asn Ala Pro Glu Gly Ile Gln Lys Val Ala Lys Cys Leu Ile Gly Val 
    450                 455                 460                 


Asn Tyr Pro Lys Pro Met Val Asn His Ala Glu Ala Ser Arg Leu Asn 
465                 470                 475                 480 


Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu Ser Arg Tyr Arg Gly 
                485                 490                 495     


Leu Gly Leu Leu Ala Ser Val Pro Ser Asn Pro Asn Gly Asn Gly Gly 
            500                 505                 510         


Phe Met Gly Tyr Ser Ala Glu Asn Ile Pro Gly Cys Ser Ser Ser Gly 
        515                 520                 525             


Ser Cys Ser Gln Gly Ser Gly Ile Leu His Tyr Ala His Gly Asp Ser 
    530                 535                 540                 


Gln Gln Thr His Leu Leu Lys Gln Gly Arg Ser Ser Met Gly Thr Gly 
545                 550                 555                 560 


Leu Ser Gly Gly Lys Arg Pro Ser Gln Glu Glu Asp Thr Gln Ser Ile 
                565                 570                 575     


Gly Pro Lys Val Gln Arg Gln Ser Thr Asn 
            580                 585     


<210>  2612
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRY2__Homo_sapiens__NP_001120929

<400>  2612

Met Pro Ala Pro Pro Gly Arg Thr His Thr Trp Phe Leu Leu Gln Ser 
1               5                   10                  15      


Leu Glu Asp Leu Asp Thr Ser Leu Arg Lys Leu Asn Ser Arg Leu Phe 
            20                  25                  30          


Val Val Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe Lys Glu 
        35                  40                  45              


Trp Gly Val Thr Arg Leu Thr Phe Glu Tyr Asp Ser Glu Pro Phe Gly 
    50                  55                  60                  


Lys Glu Arg Asp Ala Ala Ile Met Lys Met Ala Lys Glu Ala Gly Val 
65                  70                  75                  80  


Glu Val Val Thr Glu Asn Ser His Thr Leu Tyr Asp Leu Asp Arg Ile 
                85                  90                  95      


Ile Glu Leu Asn Gly Gln Lys Pro Pro Leu Thr Tyr Lys Arg Phe Gln 
            100                 105                 110         


Ala Ile Ile Ser Arg Met Glu Leu Pro Lys Lys Pro Val Gly Leu Val 
        115                 120                 125             


Thr Ser Gln Gln Met Glu Ser Cys Arg Ala Glu Ile Gln Glu Asn His 
    130                 135                 140                 


Asp Glu Thr Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe Pro Thr 
145                 150                 155                 160 


Glu Gly Leu Gly Pro Ala Val Trp Gln Gly Gly Glu Thr Glu Ala Leu 
                165                 170                 175     


Ala Arg Leu Asp Lys His Leu Glu Arg Lys Ala Trp Val Ala Asn Tyr 
            180                 185                 190         


Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly 
        195                 200                 205             


Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr 
    210                 215                 220                 


Tyr Arg Leu Trp Asp Leu Tyr Lys Lys Val Lys Arg Asn Ser Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Leu Phe Gly Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr 
                245                 250                 255     


Ala Ala Thr Asn Asn Pro Arg Phe Asp Arg Met Glu Gly Asn Pro Ile 
            260                 265                 270         


Cys Ile Gln Ile Pro Trp Asp Arg Asn Pro Glu Ala Leu Ala Lys Trp 
        275                 280                 285             


Ala Glu Gly Lys Thr Gly Phe Pro Trp Ile Asp Ala Ile Met Thr Gln 
    290                 295                 300                 


Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala Val Ala 
305                 310                 315                 320 


Cys Phe Leu Thr Arg Gly Asp Leu Trp Val Ser Trp Glu Ser Gly Val 
                325                 330                 335     


Arg Val Phe Asp Glu Leu Leu Leu Asp Ala Asp Phe Ser Val Asn Ala 
            340                 345                 350         


Gly Ser Trp Met Trp Leu Ser Cys Ser Ala Phe Phe Gln Gln Phe Phe 
        355                 360                 365             


His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro Ser Gly 
    370                 375                 380                 


Asp Tyr Ile Arg Arg Tyr Leu Pro Lys Leu Lys Ala Phe Pro Ser Arg 
385                 390                 395                 400 


Tyr Ile Tyr Glu Pro Trp Asn Ala Pro Glu Ser Ile Gln Lys Ala Ala 
                405                 410                 415     


Lys Cys Ile Ile Gly Val Asp Tyr Pro Arg Pro Ile Val Asn His Ala 
            420                 425                 430         


Glu Thr Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln 
        435                 440                 445             


Leu Ser Arg Tyr Arg Gly Leu Cys Leu Leu Ala Ser Val Pro Ser Cys 
    450                 455                 460                 


Val Glu Asp Leu Ser His Pro Val Ala Glu Pro Ser Ser Ser Gln Ala 
465                 470                 475                 480 


Gly Ser Met Ser Ser Ala Gly Pro Arg Pro Leu Pro Ser Gly Pro Ala 
                485                 490                 495     


Ser Pro Lys Arg Lys Leu Glu Ala Ala Glu Glu Pro Pro Gly Glu Glu 
            500                 505                 510         


Leu Ser Lys Arg Ala Arg Val Ala Glu Leu Pro Thr Pro Glu Leu Pro 
        515                 520                 525             


Ser Lys Asp Ala 
    530         


<210>  2613
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYAB__Homo_sapiens__NP_001276737

<400>  2613

Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro 
1               5                   10                  15      


Phe His Ser Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu 
            20                  25                  30          


Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro Phe Tyr 
        35                  40                  45              


Leu Arg Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly 
    50                  55                  60                  


Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 
                85                  90                  95      


Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 
            100                 105                 110         


Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala Asp Val 
        115                 120                 125             


Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr 
    130                 135                 140                 


Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu Arg Thr Ile Pro 
145                 150                 155                 160 


Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys 
                165                 170                 175 


<210>  2614
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYBA1__Homo_sapiens__NP_005199

<400>  2614

Met Glu Thr Gln Ala Glu Gln Gln Glu Leu Glu Thr Leu Pro Thr Thr 
1               5                   10                  15      


Lys Met Ala Gln Thr Asn Pro Thr Pro Gly Ser Leu Gly Pro Trp Lys 
            20                  25                  30          


Ile Thr Ile Tyr Asp Gln Glu Asn Phe Gln Gly Lys Arg Met Glu Phe 
        35                  40                  45              


Thr Ser Ser Cys Pro Asn Val Ser Glu Arg Ser Phe Asp Asn Val Arg 
    50                  55                  60                  


Ser Leu Lys Val Glu Ser Gly Ala Trp Ile Gly Tyr Glu His Thr Ser 
65                  70                  75                  80  


Phe Cys Gly Gln Gln Phe Ile Leu Glu Arg Gly Glu Tyr Pro Arg Trp 
                85                  90                  95      


Asp Ala Trp Ser Gly Ser Asn Ala Tyr His Ile Glu Arg Leu Met Ser 
            100                 105                 110         


Phe Arg Pro Ile Cys Ser Ala Asn His Lys Glu Ser Lys Met Thr Ile 
        115                 120                 125             


Phe Glu Lys Glu Asn Phe Ile Gly Arg Gln Trp Glu Ile Ser Asp Asp 
    130                 135                 140                 


Tyr Pro Ser Leu Gln Ala Met Gly Trp Phe Asn Asn Glu Val Gly Ser 
145                 150                 155                 160 


Met Lys Ile Gln Ser Gly Ala Trp Val Cys Tyr Gln Tyr Pro Gly Tyr 
                165                 170                 175     


Arg Gly Tyr Gln Tyr Ile Leu Glu Cys Asp His His Gly Gly Asp Tyr 
            180                 185                 190         


Lys His Trp Arg Glu Trp Gly Ser His Ala Gln Thr Ser Gln Ile Gln 
        195                 200                 205             


Ser Ile Arg Arg Ile Gln Gln 
    210                 215 


<210>  2615
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYBA2__Homo_sapiens__NP_476434

<400>  2615

Met Ser Ser Ala Pro Ala Pro Gly Pro Ala Pro Ala Ser Leu Thr Leu 
1               5                   10                  15      


Trp Asp Glu Glu Asp Phe Gln Gly Arg Arg Cys Arg Leu Leu Ser Asp 
            20                  25                  30          


Cys Ala Asn Val Cys Glu Arg Gly Gly Leu Pro Arg Val Arg Ser Val 
        35                  40                  45              


Lys Val Glu Asn Gly Val Trp Val Ala Phe Glu Tyr Pro Asp Phe Gln 
    50                  55                  60                  


Gly Gln Gln Phe Ile Leu Glu Lys Gly Asp Tyr Pro Arg Trp Ser Ala 
65                  70                  75                  80  


Trp Ser Gly Ser Ser Ser His Asn Ser Asn Gln Leu Leu Ser Phe Arg 
                85                  90                  95      


Pro Val Leu Cys Ala Asn His Asn Asp Ser Arg Val Thr Leu Phe Glu 
            100                 105                 110         


Gly Asp Asn Phe Gln Gly Cys Lys Phe Asp Leu Val Asp Asp Tyr Pro 
        115                 120                 125             


Ser Leu Pro Ser Met Gly Trp Ala Ser Lys Asp Val Gly Ser Leu Lys 
    130                 135                 140                 


Val Ser Ser Gly Ala Trp Val Ala Tyr Gln Tyr Pro Gly Tyr Arg Gly 
145                 150                 155                 160 


Tyr Gln Tyr Val Leu Glu Arg Asp Arg His Ser Gly Glu Phe Cys Thr 
                165                 170                 175     


Tyr Gly Glu Leu Gly Thr Gln Ala His Thr Gly Gln Leu Gln Ser Ile 
            180                 185                 190         


Arg Arg Val Gln His 
        195         


<210>  2616
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYBA4__Homo_sapiens__NP_001877

<400>  2616

Met Thr Leu Gln Cys Thr Lys Ser Ala Gly Pro Trp Lys Met Val Val 
1               5                   10                  15      


Trp Asp Glu Asp Gly Phe Gln Gly Arg Arg His Glu Phe Thr Ala Glu 
            20                  25                  30          


Cys Pro Ser Val Leu Glu Leu Gly Phe Glu Thr Val Arg Ser Leu Lys 
        35                  40                  45              


Val Leu Ser Gly Ala Trp Val Gly Phe Glu His Ala Gly Phe Gln Gly 
    50                  55                  60                  


Gln Gln Tyr Ile Leu Glu Arg Gly Glu Tyr Pro Ser Trp Asp Ala Trp 
65                  70                  75                  80  


Gly Gly Asn Thr Ala Tyr Pro Ala Glu Arg Leu Thr Ser Phe Arg Pro 
                85                  90                  95      


Ala Ala Cys Ala Asn His Arg Asp Ser Arg Leu Thr Ile Phe Glu Gln 
            100                 105                 110         


Glu Asn Phe Leu Gly Lys Lys Gly Glu Leu Ser Asp Asp Tyr Pro Ser 
        115                 120                 125             


Leu Gln Ala Met Gly Trp Glu Gly Asn Glu Val Gly Ser Phe His Val 
    130                 135                 140                 


His Ser Gly Ala Trp Val Cys Ser Gln Phe Pro Gly Tyr Arg Gly Phe 
145                 150                 155                 160 


Gln Tyr Val Leu Glu Cys Asp His His Ser Gly Asp Tyr Lys His Phe 
                165                 170                 175     


Arg Glu Trp Gly Ser His Ala Pro Thr Phe Gln Val Gln Ser Ile Arg 
            180                 185                 190         


Arg Ile Gln Gln 
        195     


<210>  2617
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYBB1__Homo_sapiens__NP_001878

<400>  2617

Met Ser Gln Ala Ala Lys Ala Ser Ala Ser Ala Thr Val Ala Val Asn 
1               5                   10                  15      


Pro Gly Pro Asp Thr Lys Gly Lys Gly Ala Pro Pro Ala Gly Thr Ser 
            20                  25                  30          


Pro Ser Pro Gly Thr Thr Leu Ala Pro Thr Thr Val Pro Ile Thr Ser 
        35                  40                  45              


Ala Lys Ala Ala Glu Leu Pro Pro Gly Asn Tyr Arg Leu Val Val Phe 
    50                  55                  60                  


Glu Leu Glu Asn Phe Gln Gly Arg Arg Ala Glu Phe Ser Gly Glu Cys 
65                  70                  75                  80  


Ser Asn Leu Ala Asp Arg Gly Phe Asp Arg Val Arg Ser Ile Ile Val 
                85                  90                  95      


Ser Ala Gly Pro Trp Val Ala Phe Glu Gln Ser Asn Phe Arg Gly Glu 
            100                 105                 110         


Met Phe Ile Leu Glu Lys Gly Glu Tyr Pro Arg Trp Asn Thr Trp Ser 
        115                 120                 125             


Ser Ser Tyr Arg Ser Asp Arg Leu Met Ser Phe Arg Pro Ile Lys Met 
    130                 135                 140                 


Asp Ala Gln Glu His Lys Ile Ser Leu Phe Glu Gly Ala Asn Phe Lys 
145                 150                 155                 160 


Gly Asn Thr Ile Glu Ile Gln Gly Asp Asp Ala Pro Ser Leu Trp Val 
                165                 170                 175     


Tyr Gly Phe Ser Asp Arg Val Gly Ser Val Lys Val Ser Ser Gly Thr 
            180                 185                 190         


Trp Val Gly Tyr Gln Tyr Pro Gly Tyr Arg Gly Tyr Gln Tyr Leu Leu 
        195                 200                 205             


Glu Pro Gly Asp Phe Arg His Trp Asn Glu Trp Gly Ala Phe Gln Pro 
    210                 215                 220                 


Gln Met Gln Ser Leu Arg Arg Leu Arg Asp Lys Gln Trp His Leu Glu 
225                 230                 235                 240 


Gly Ser Phe Pro Val Leu Ala Thr Glu Pro Pro Lys 
                245                 250         


<210>  2618
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYBB2__Homo_sapiens__NP_000487

<400>  2618

Met Ala Ser Asp His Gln Thr Gln Ala Gly Lys Pro Gln Ser Leu Asn 
1               5                   10                  15      


Pro Lys Ile Ile Ile Phe Glu Gln Glu Asn Phe Gln Gly His Ser His 
            20                  25                  30          


Glu Leu Asn Gly Pro Cys Pro Asn Leu Lys Glu Thr Gly Val Glu Lys 
        35                  40                  45              


Ala Gly Ser Val Leu Val Gln Ala Gly Pro Trp Val Gly Tyr Glu Gln 
    50                  55                  60                  


Ala Asn Cys Lys Gly Glu Gln Phe Val Phe Glu Lys Gly Glu Tyr Pro 
65                  70                  75                  80  


Arg Trp Asp Ser Trp Thr Ser Ser Arg Arg Thr Asp Ser Leu Ser Ser 
                85                  90                  95      


Leu Arg Pro Ile Lys Val Asp Ser Gln Glu His Lys Ile Ile Leu Tyr 
            100                 105                 110         


Glu Asn Pro Asn Phe Thr Gly Lys Lys Met Glu Ile Ile Asp Asp Asp 
        115                 120                 125             


Val Pro Ser Phe His Ala His Gly Tyr Gln Glu Lys Val Ser Ser Val 
    130                 135                 140                 


Arg Val Gln Ser Gly Thr Trp Val Gly Tyr Gln Tyr Pro Gly Tyr Arg 
145                 150                 155                 160 


Gly Leu Gln Tyr Leu Leu Glu Lys Gly Asp Tyr Lys Asp Ser Ser Asp 
                165                 170                 175     


Phe Gly Ala Pro His Pro Gln Val Gln Ser Val Arg Arg Ile Arg Asp 
            180                 185                 190         


Met Gln Trp His Gln Arg Gly Ala Phe His Pro Ser Asn 
        195                 200                 205 


<210>  2619
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYBB3__Homo_sapiens__NP_004067

<400>  2619

Met Ala Glu Gln His Gly Ala Pro Glu Gln Ala Ala Ala Gly Lys Ser 
1               5                   10                  15      


His Gly Asp Leu Gly Gly Ser Tyr Lys Val Ile Leu Tyr Glu Leu Glu 
            20                  25                  30          


Asn Phe Gln Gly Lys Arg Cys Glu Leu Ser Ala Glu Cys Pro Ser Leu 
        35                  40                  45              


Thr Asp Ser Leu Leu Glu Lys Val Gly Ser Ile Gln Val Glu Ser Gly 
    50                  55                  60                  


Pro Trp Leu Ala Phe Glu Ser Arg Ala Phe Arg Gly Glu Gln Phe Val 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Tyr Pro Arg Trp Asp Ala Trp Ser Asn Ser Arg 
                85                  90                  95      


Asp Ser Asp Ser Leu Leu Ser Leu Arg Pro Leu Asn Ile Asp Ser Pro 
            100                 105                 110         


His His Lys Leu His Leu Phe Glu Asn Pro Ala Phe Ser Gly Arg Lys 
        115                 120                 125             


Met Glu Ile Val Asp Asp Asp Val Pro Ser Leu Trp Ala His Gly Phe 
    130                 135                 140                 


Gln Asp Arg Val Ala Ser Val Arg Ala Ile Asn Gly Thr Trp Val Gly 
145                 150                 155                 160 


Tyr Glu Phe Pro Gly Tyr Arg Gly Arg Gln Tyr Val Phe Glu Arg Gly 
                165                 170                 175     


Glu Tyr Arg His Trp Asn Glu Trp Asp Ala Ser Gln Pro Gln Leu Gln 
            180                 185                 190         


Ser Val Arg Arg Ile Arg Asp Gln Lys Trp His Lys Arg Gly Arg Phe 
        195                 200                 205             


Pro Ser Ser 
    210     


<210>  2620
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYGB__Homo_sapiens__NP_005201

<400>  2620

Met Gly Lys Ile Thr Phe Tyr Glu Asp Arg Ala Phe Gln Gly Arg Ser 
1               5                   10                  15      


Tyr Glu Cys Thr Thr Asp Cys Pro Asn Leu Gln Pro Tyr Phe Ser Arg 
            20                  25                  30          


Cys Asn Ser Ile Arg Val Glu Ser Gly Cys Trp Met Ile Tyr Glu Arg 
        35                  40                  45              


Pro Asn Tyr Gln Gly His Gln Tyr Phe Leu Arg Arg Gly Glu Tyr Pro 
    50                  55                  60                  


Asp Tyr Gln Gln Trp Met Gly Leu Ser Asp Ser Ile Arg Ser Cys Cys 
65                  70                  75                  80  


Leu Ile Pro Pro His Ser Gly Ala Tyr Arg Met Lys Ile Tyr Asp Arg 
                85                  90                  95      


Asp Glu Leu Arg Gly Gln Met Ser Glu Leu Thr Asp Asp Cys Ile Ser 
            100                 105                 110         


Val Gln Asp Arg Phe His Leu Thr Glu Ile His Ser Leu Asn Val Leu 
        115                 120                 125             


Glu Gly Ser Trp Ile Leu Tyr Glu Met Pro Asn Tyr Arg Gly Arg Gln 
    130                 135                 140                 


Tyr Leu Leu Arg Pro Gly Glu Tyr Arg Arg Phe Leu Asp Trp Gly Ala 
145                 150                 155                 160 


Pro Asn Ala Lys Val Gly Ser Leu Arg Arg Val Met Asp Leu Tyr 
                165                 170                 175 


<210>  2621
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYGC__Homo_sapiens__NP_066269

<400>  2621

Met Gly Lys Ile Thr Phe Tyr Glu Asp Arg Ala Phe Gln Gly Arg Ser 
1               5                   10                  15      


Tyr Glu Thr Thr Thr Asp Cys Pro Asn Leu Gln Pro Tyr Phe Ser Arg 
            20                  25                  30          


Cys Asn Ser Ile Arg Val Glu Ser Gly Cys Trp Met Leu Tyr Glu Arg 
        35                  40                  45              


Pro Asn Tyr Gln Gly Gln Gln Tyr Leu Leu Arg Arg Gly Glu Tyr Pro 
    50                  55                  60                  


Asp Tyr Gln Gln Trp Met Gly Leu Ser Asp Ser Ile Arg Ser Cys Cys 
65                  70                  75                  80  


Leu Ile Pro Gln Thr Val Ser His Arg Leu Arg Leu Tyr Glu Arg Glu 
                85                  90                  95      


Asp His Lys Gly Leu Met Met Glu Leu Ser Glu Asp Cys Pro Ser Ile 
            100                 105                 110         


Gln Asp Arg Phe His Leu Ser Glu Ile Arg Ser Leu His Val Leu Glu 
        115                 120                 125             


Gly Cys Trp Val Leu Tyr Glu Leu Pro Asn Tyr Arg Gly Arg Gln Tyr 
    130                 135                 140                 


Leu Leu Arg Pro Gln Glu Tyr Arg Arg Cys Gln Asp Trp Gly Ala Met 
145                 150                 155                 160 


Asp Ala Lys Ala Gly Ser Leu Arg Arg Val Val Asp Leu Tyr 
                165                 170                 


<210>  2622
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYGD__Homo_sapiens__NP_008822

<400>  2622

Met Gly Lys Ile Thr Leu Tyr Glu Asp Arg Gly Phe Gln Gly Arg His 
1               5                   10                  15      


Tyr Glu Cys Ser Ser Asp His Pro Asn Leu Gln Pro Tyr Leu Ser Arg 
            20                  25                  30          


Cys Asn Ser Ala Arg Val Asp Ser Gly Cys Trp Met Leu Tyr Glu Gln 
        35                  40                  45              


Pro Asn Tyr Ser Gly Leu Gln Tyr Phe Leu Arg Arg Gly Asp Tyr Ala 
    50                  55                  60                  


Asp His Gln Gln Trp Met Gly Leu Ser Asp Ser Val Arg Ser Cys Arg 
65                  70                  75                  80  


Leu Ile Pro His Ser Gly Ser His Arg Ile Arg Leu Tyr Glu Arg Glu 
                85                  90                  95      


Asp Tyr Arg Gly Gln Met Ile Glu Phe Thr Glu Asp Cys Ser Cys Leu 
            100                 105                 110         


Gln Asp Arg Phe Arg Phe Asn Glu Ile His Ser Leu Asn Val Leu Glu 
        115                 120                 125             


Gly Ser Trp Val Leu Tyr Glu Leu Ser Asn Tyr Arg Gly Arg Gln Tyr 
    130                 135                 140                 


Leu Leu Met Pro Gly Asp Tyr Arg Arg Tyr Gln Asp Trp Gly Ala Thr 
145                 150                 155                 160 


Asn Ala Arg Val Gly Ser Leu Arg Arg Val Ile Asp Phe Ser 
                165                 170                 


<210>  2623
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYGS__Homo_sapiens__NP_060011

<400>  2623

Met Ser Lys Thr Gly Thr Lys Ile Thr Phe Tyr Glu Asp Lys Asn Phe 
1               5                   10                  15      


Gln Gly Arg Arg Tyr Asp Cys Asp Cys Asp Cys Ala Asp Phe His Thr 
            20                  25                  30          


Tyr Leu Ser Arg Cys Asn Ser Ile Lys Val Glu Gly Gly Thr Trp Ala 
        35                  40                  45              


Val Tyr Glu Arg Pro Asn Phe Ala Gly Tyr Met Tyr Ile Leu Pro Gln 
    50                  55                  60                  


Gly Glu Tyr Pro Glu Tyr Gln Arg Trp Met Gly Leu Asn Asp Arg Leu 
65                  70                  75                  80  


Ser Ser Cys Arg Ala Val His Leu Pro Ser Gly Gly Gln Tyr Lys Ile 
                85                  90                  95      


Gln Ile Phe Glu Lys Gly Asp Phe Ser Gly Gln Met Tyr Glu Thr Thr 
            100                 105                 110         


Glu Asp Cys Pro Ser Ile Met Glu Gln Phe His Met Arg Glu Ile His 
        115                 120                 125             


Ser Cys Lys Val Leu Glu Gly Val Trp Ile Phe Tyr Glu Leu Pro Asn 
    130                 135                 140                 


Tyr Arg Gly Arg Gln Tyr Leu Leu Asp Lys Lys Glu Tyr Arg Lys Pro 
145                 150                 155                 160 


Ile Asp Trp Gly Ala Ala Ser Pro Ala Val Gln Ser Phe Arg Arg Ile 
                165                 170                 175     


Val Glu 
        


<210>  2624
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYL1__Homo_sapiens__NP_057058

<400>  2624

Met Ala Ser Ser Ala Ala Gly Cys Val Val Ile Val Gly Ser Gly Val 
1               5                   10                  15      


Ile Gly Arg Ser Trp Ala Met Leu Phe Ala Ser Gly Gly Phe Gln Val 
            20                  25                  30          


Lys Leu Tyr Asp Ile Glu Gln Gln Gln Ile Arg Asn Ala Leu Glu Asn 
        35                  40                  45              


Ile Arg Lys Glu Met Lys Leu Leu Glu Gln Ala Gly Ser Leu Lys Gly 
    50                  55                  60                  


Ser Leu Ser Val Glu Glu Gln Leu Ser Leu Ile Ser Gly Cys Pro Asn 
65                  70                  75                  80  


Ile Gln Glu Ala Val Glu Gly Ala Met His Ile Gln Glu Cys Val Pro 
                85                  90                  95      


Glu Asp Leu Glu Leu Lys Lys Lys Ile Phe Ala Gln Leu Asp Ser Ile 
            100                 105                 110         


Ile Asp Asp Arg Val Ile Leu Ser Ser Ser Thr Ser Cys Leu Met Pro 
        115                 120                 125             


Ser Lys Leu Phe Ala Gly Leu Val His Val Lys Gln Cys Ile Val Ala 
    130                 135                 140                 


His Pro Val Asn Pro Pro Tyr Tyr Ile Pro Leu Val Glu Leu Val Pro 
145                 150                 155                 160 


His Pro Glu Thr Ala Pro Thr Thr Val Asp Arg Thr His Ala Leu Met 
                165                 170                 175     


Lys Lys Ile Gly Gln Cys Pro Met Arg Val Gln Lys Glu Val Ala Gly 
            180                 185                 190         


Phe Val Leu Asn Arg Leu Gln Tyr Ala Ile Ile Ser Glu Ala Trp Arg 
        195                 200                 205             


Leu Val Glu Glu Gly Ile Val Ser Pro Ser Asp Leu Asp Leu Val Met 
    210                 215                 220                 


Ser Glu Gly Leu Gly Met Arg Tyr Ala Phe Ile Gly Pro Leu Glu Thr 
225                 230                 235                 240 


Met His Leu Asn Ala Glu Gly Met Leu Ser Tyr Cys Asp Arg Tyr Ser 
                245                 250                 255     


Glu Gly Ile Lys His Val Leu Gln Thr Phe Gly Pro Ile Pro Glu Phe 
            260                 265                 270         


Ser Arg Ala Thr Ala Glu Lys Val Asn Gln Asp Met Cys Met Lys Val 
        275                 280                 285             


Pro Asp Asp Pro Glu His Leu Ala Ala Arg Arg Gln Trp Arg Asp Glu 
    290                 295                 300                 


Cys Leu Met Arg Leu Ala Lys Leu Lys Ser Gln Val Gln Pro Gln 
305                 310                 315                 


<210>  2625
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYM__Homo_sapiens__NP_001879

<400>  2625

Met Ser Arg Val Pro Ala Phe Leu Ser Ala Ala Glu Val Glu Glu His 
1               5                   10                  15      


Leu Arg Ser Ser Ser Leu Leu Ile Pro Pro Leu Glu Thr Ala Leu Ala 
            20                  25                  30          


Asn Phe Ser Ser Gly Pro Glu Gly Gly Val Met Gln Pro Val Arg Thr 
        35                  40                  45              


Val Val Pro Val Thr Lys His Arg Gly Tyr Leu Gly Val Met Pro Ala 
    50                  55                  60                  


Tyr Ser Ala Ala Glu Asp Ala Leu Thr Thr Lys Leu Val Thr Phe Tyr 
65                  70                  75                  80  


Glu Asp Arg Gly Ile Thr Ser Val Val Pro Ser His Gln Ala Thr Val 
                85                  90                  95      


Leu Leu Phe Glu Pro Ser Asn Gly Thr Leu Leu Ala Val Met Asp Gly 
            100                 105                 110         


Asn Val Ile Thr Ala Lys Arg Thr Ala Ala Val Ser Ala Ile Ala Thr 
        115                 120                 125             


Lys Phe Leu Lys Pro Pro Ser Ser Glu Val Leu Cys Ile Leu Gly Ala 
    130                 135                 140                 


Gly Val Gln Ala Tyr Ser His Tyr Glu Ile Phe Thr Glu Gln Phe Ser 
145                 150                 155                 160 


Phe Lys Glu Val Arg Ile Trp Asn Arg Thr Lys Glu Asn Ala Glu Lys 
                165                 170                 175     


Phe Ala Asp Thr Val Gln Gly Glu Val Arg Val Cys Ser Ser Val Gln 
            180                 185                 190         


Glu Ala Val Ala Gly Ala Asp Val Ile Ile Thr Val Thr Leu Ala Thr 
        195                 200                 205             


Glu Pro Ile Leu Phe Gly Glu Trp Val Lys Pro Gly Ala His Ile Asn 
    210                 215                 220                 


Ala Val Gly Ala Ser Arg Pro Asp Trp Arg Glu Leu Asp Asp Glu Leu 
225                 230                 235                 240 


Met Lys Glu Ala Val Leu Tyr Val Asp Ser Gln Glu Ala Ala Leu Lys 
                245                 250                 255     


Glu Ser Gly Asp Val Leu Leu Ser Gly Ala Glu Ile Phe Ala Glu Leu 
            260                 265                 270         


Gly Glu Val Ile Lys Gly Val Lys Pro Ala His Cys Glu Lys Thr Thr 
        275                 280                 285             


Val Phe Lys Ser Leu Gly Met Ala Val Glu Asp Thr Val Ala Ala Lys 
    290                 295                 300                 


Leu Ile Tyr Asp Ser Trp Ser Ser Gly Lys 
305                 310                 


<210>  2626
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRYZL1__Homo_sapiens__NP_665857

<400>  2626

Met Lys Gly Leu Tyr Phe Gln Gln Ser Ser Thr Asp Glu Glu Ile Thr 
1               5                   10                  15      


Phe Val Phe Gln Glu Lys Glu Asp Leu Pro Val Thr Glu Asp Asn Phe 
            20                  25                  30          


Val Lys Leu Gln Val Lys Ala Cys Ala Leu Ser Gln Ile Asn Thr Lys 
        35                  40                  45              


Leu Leu Ala Glu Met Lys Met Lys Lys Asp Leu Phe Pro Val Gly Arg 
    50                  55                  60                  


Glu Ile Ala Gly Ile Val Leu Asp Val Gly Ser Lys Val Ser Phe Phe 
65                  70                  75                  80  


Gln Pro Asp Asp Glu Val Val Gly Ile Leu Pro Leu Asp Ser Glu Asp 
                85                  90                  95      


Pro Gly Leu Cys Glu Val Val Arg Val His Glu His Tyr Leu Val His 
            100                 105                 110         


Lys Pro Glu Lys Val Thr Trp Thr Glu Ala Ala Gly Ser Ile Arg Asp 
        115                 120                 125             


Gly Val Arg Ala Tyr Thr Ala Leu His Tyr Leu Ser His Leu Ser Pro 
    130                 135                 140                 


Gly Lys Ser Val Leu Ile Met Asp Gly Ala Ser Ala Phe Gly Thr Ile 
145                 150                 155                 160 


Ala Ile Gln Leu Ala His His Arg Gly Ala Lys Val Ile Ser Thr Ala 
                165                 170                 175     


Cys Ser Leu Glu Asp Lys Gln Cys Leu Glu Arg Phe Arg Pro Pro Ile 
            180                 185                 190         


Ala Arg Val Ile Asp Val Ser Asn Gly Lys Val His Val Ala Glu Ser 
        195                 200                 205             


Cys Leu Glu Glu Thr Gly Gly Leu Gly Val Asp Ile Val Leu Asp Ala 
    210                 215                 220                 


Gly Val Arg Leu Tyr Ser Lys Asp Asp Glu Pro Ala Val Lys Leu Gln 
225                 230                 235                 240 


Leu Leu Pro His Lys His Asp Ile Ile Thr Leu Leu Gly Val Gly Gly 
                245                 250                 255     


His Trp Val Thr Thr Glu Glu Asn Leu Gln Leu Asp Pro Pro Asp Ser 
            260                 265                 270         


His Cys Leu Phe Leu Lys Gly Ala Thr Leu Ala Phe Leu Asn Asp Glu 
        275                 280                 285             


Val Trp Asn Leu Ser Asn Val Gln Gln Gly Lys Tyr Leu Cys Ile Leu 
    290                 295                 300                 


Lys Asp Val Met Glu Lys Leu Ser Thr Gly Val Phe Arg Pro Gln Leu 
305                 310                 315                 320 


Asp Glu Pro Ile Pro Leu Tyr Glu Ala Lys Val Ser Met Glu Ala Val 
                325                 330                 335     


Gln Lys Asn Gln Gly Arg Lys Lys Gln Val Val Gln Phe 
            340                 345                 


<210>  2627
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSAD__Homo_sapiens__NP_001231634

<400>  2627

Met Ala Asp Ser Glu Ala Leu Pro Ser Leu Ala Gly Asp Pro Val Ala 
1               5                   10                  15      


Val Glu Ala Leu Leu Arg Ala Val Phe Gly Val Val Val Asp Glu Ala 
            20                  25                  30          


Ile Gln Lys Gly Thr Ser Val Ser Gln Lys Val Cys Glu Trp Lys Glu 
        35                  40                  45              


Pro Glu Glu Leu Lys Gln Leu Leu Asp Leu Glu Leu Arg Ser Gln Gly 
    50                  55                  60                  


Glu Ser Gln Lys Gln Ile Leu Glu Arg Cys Arg Ala Val Ile Arg Tyr 
65                  70                  75                  80  


Ser Val Lys Thr Gly His Pro Arg Phe Phe Asn Gln Leu Phe Ser Gly 
                85                  90                  95      


Leu Asp Pro His Ala Leu Ala Gly Arg Ile Ile Thr Glu Ser Leu Asn 
            100                 105                 110         


Thr Ser Gln Tyr Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu 
        115                 120                 125             


Glu Glu Val Leu Arg Lys Leu Arg Ala Leu Val Gly Trp Ser Ser Gly 
    130                 135                 140                 


Asp Gly Ile Phe Cys Pro Gly Gly Ser Ile Ser Asn Met Tyr Ala Val 
145                 150                 155                 160 


Asn Leu Ala Arg Tyr Gln Arg Tyr Pro Asp Cys Lys Gln Arg Gly Leu 
                165                 170                 175     


Arg Thr Leu Pro Pro Leu Ala Leu Phe Thr Ser Lys Glu Cys His Tyr 
            180                 185                 190         


Ser Ile Gln Lys Gly Ala Ala Phe Leu Gly Leu Gly Thr Asp Ser Val 
        195                 200                 205             


Arg Val Val Lys Ala Asp Glu Arg Gly Lys Met Val Pro Glu Asp Leu 
    210                 215                 220                 


Glu Arg Gln Ile Gly Met Ala Glu Ala Glu Gly Ala Val Pro Phe Leu 
225                 230                 235                 240 


Val Ser Ala Thr Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu 
                245                 250                 255     


Glu Ala Ile Ala Asp Val Cys Gln Arg His Gly Leu Trp Leu His Val 
            260                 265                 270         


Asp Ala Ala Trp Gly Gly Ser Val Leu Leu Ser Gln Thr His Arg His 
        275                 280                 285             


Leu Leu Asp Gly Ile Gln Arg Ala Asp Ser Val Ala Trp Asn Pro His 
    290                 295                 300                 


Lys Leu Leu Ala Ala Gly Leu Gln Cys Ser Ala Leu Leu Leu Gln Asp 
305                 310                 315                 320 


Thr Ser Asn Leu Leu Lys Arg Cys His Gly Ser Gln Ala Ser Tyr Leu 
                325                 330                 335     


Phe Gln Gln Asp Lys Phe Tyr Asp Val Ala Leu Asp Thr Gly Asp Lys 
            340                 345                 350         


Val Val Gln Cys Gly Arg Arg Val Asp Cys Leu Lys Leu Trp Leu Met 
        355                 360                 365             


Trp Lys Ala Gln Gly Asp Gln Gly Leu Glu Arg Arg Ile Asp Gln Ala 
    370                 375                 380                 


Phe Val Leu Ala Arg Tyr Leu Val Glu Glu Met Lys Lys Arg Glu Gly 
385                 390                 395                 400 


Phe Glu Leu Val Met Glu Pro Glu Phe Val Asn Val Cys Phe Trp Phe 
                405                 410                 415     


Val Pro Pro Ser Leu Arg Gly Lys Gln Glu Ser Pro Asp Tyr His Glu 
            420                 425                 430         


Arg Leu Ser Lys Val Ala Pro Val Leu Lys Glu Arg Met Val Lys Glu 
        435                 440                 445             


Gly Ser Met Met Ile Gly Tyr Gln Pro His Gly Thr Arg Gly Asn Phe 
    450                 455                 460                 


Phe Arg Val Val Val Ala Asn Ser Ala Leu Thr Cys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Leu Leu Asn Glu Leu Glu Arg Leu Gly Gln Asp Leu 
                485                 490             


<210>  2628
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSAG3__Homo_sapiens__NP_001123300

<400>  2628

Met Trp Met Gly Leu Ile Gln Leu Val Glu Gly Val Lys Arg Lys Asp 
1               5                   10                  15      


Gln Gly Phe Leu Glu Lys Glu Phe Tyr His Lys Thr Asn Ile Lys Met 
            20                  25                  30          


Arg Cys Glu Phe Leu Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
        35                  40                  45              


Ala Trp Arg Asp Gln Val Asp Trp Ser Arg Leu Leu Arg Asp Ala Gly 
    50                  55                  60                  


Leu Val Lys Met Ser Arg Lys Pro Arg Ala Ser Ser Pro Leu Ser Asn 
65                  70                  75                  80  


Asn His Pro Pro Thr Pro Lys Arg Phe Pro Arg Gln Pro Gly Arg Glu 
                85                  90                  95      


Lys Gly Pro Ile Lys Glu Val Pro Gly Thr Lys Gly Ser Pro 
            100                 105                 110 


<210>  2629
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSE1L__Homo_sapiens__NP_001243064

<400>  2629

Met Glu Leu Ser Asp Ala Asn Leu Gln Thr Leu Thr Glu Tyr Leu Lys 
1               5                   10                  15      


Lys Thr Leu Asp Pro Asp Pro Ala Ile Arg Arg Pro Ala Glu Lys Phe 
            20                  25                  30          


Leu Glu Ser Val Glu Gly Asn Gln Asn Tyr Pro Leu Leu Leu Leu Thr 
        35                  40                  45              


Leu Leu Glu Lys Ser Gln Asp Asn Val Ile Lys Val Cys Ala Ser Val 
    50                  55                  60                  


Thr Phe Lys Asn Tyr Ile Lys Arg Asn Trp Arg Ile Val Glu Asp Glu 
65                  70                  75                  80  


Pro Asn Lys Ile Cys Glu Ala Asp Arg Val Ala Ile Lys Ala Asn Ile 
                85                  90                  95      


Val His Leu Met Leu Ser Ser Pro Glu Gln Ile Gln Lys Gln Leu Ser 
            100                 105                 110         


Asp Ala Ile Ser Ile Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro 
        115                 120                 125             


Asp Leu Leu Thr Glu Met Val Asn Arg Phe Gln Ser Gly Asp Phe His 
    130                 135                 140                 


Val Ile Asn Gly Val Leu Arg Thr Ala His Ser Leu Phe Lys Arg Tyr 
145                 150                 155                 160 


Arg His Glu Phe Lys Ser Asn Glu Leu Trp Thr Glu Ile Lys Leu Val 
                165                 170                 175     


Leu Asp Ala Phe Ala Leu Pro Leu Thr Asn Leu Phe Lys Ala Thr Ile 
            180                 185                 190         


Glu Leu Cys Ser Thr His Ala Asn Asp Ala Ser Ala Leu Arg Ile Leu 
        195                 200                 205             


Phe Ser Ser Leu Ile Leu Ile Ser Lys Leu Phe Tyr Ser Leu Asn Phe 
    210                 215                 220                 


Gln Asp Leu Pro Glu Phe Phe Glu Asp Asn Met Glu Thr Trp Met Asn 
225                 230                 235                 240 


Asn Phe His Thr Leu Leu Thr Leu Asp Asn Lys Leu Leu Gln Thr Asp 
                245                 250                 255     


Leu Val Ser Asn Ala Ile Gln Phe Leu Ala Ser Val Cys Glu Arg Pro 
            260                 265                 270         


His Tyr Lys Asn Leu Phe Glu Asp Gln Asn Thr Leu Thr Ser Ile Cys 
        275                 280                 285             


Glu Lys Val Ile Val Pro Asn Met Glu Phe Arg Ala Ala Asp Glu Glu 
    290                 295                 300                 


Ala Phe Glu Asp Asn Ser Glu Glu Tyr Ile Arg Arg Asp Leu Glu Gly 
305                 310                 315                 320 


Ser Asp Ile Asp Thr Arg Arg Arg Ala Ala Cys Asp Leu Val Arg Gly 
                325                 330                 335     


Leu Cys Lys Phe Phe Glu Gly Pro Val Thr Gly Ile Phe Ser Gly Tyr 
            340                 345                 350         


Val Asn Ser Met Leu Gln Glu Tyr Ala Lys Asn Pro Ser Val Asn Trp 
        355                 360                 365             


Lys His Lys Asp Ala Ala Ile Tyr Leu Val Thr Ser Leu Ala Ser Lys 
    370                 375                 380                 


Ala Gln Thr Gln Lys His Gly Ile Thr Gln Ala Asn Glu Leu Val Asn 
385                 390                 395                 400 


Leu Thr Glu Phe Phe Val Asn His Ile Leu Pro Asp Leu Lys Ser Ala 
                405                 410                 415     


Asn Val Asn Glu Phe Pro Val Leu Lys Ala Asp Gly Ile Lys Tyr Ile 
            420                 425                 430         


Met Ile Phe Arg Asn Gln Val Pro Lys Glu His Leu Leu Val Ser Ile 
        435                 440                 445             


Pro Leu Leu Ile Asn His Leu Gln Ala Glu Ser Ile Val Val His Thr 
    450                 455                 460                 


Tyr Ala Ala His Ala Leu Glu Arg Leu Phe Thr Met Arg Gly Pro Asn 
465                 470                 475                 480 


Asn Ala Thr Leu Phe Thr Ala Ala Glu Ile Ala Pro Phe Val Glu Ile 
                485                 490                 495     


Leu Leu Thr Asn Leu Phe Lys Ala Leu Thr Leu Pro Gly Ser Ser Glu 
            500                 505                 510         


Asn Glu Tyr Ile Met Lys Ala Ile Met Arg Ser Phe Ser Leu Leu Gln 
        515                 520                 525             


Glu Ala Ile Ile Pro Tyr Ile Pro Thr Leu Ile Thr Gln Leu Thr Gln 
    530                 535                 540                 


Lys Leu Leu Ala Val Ser Lys Asn Pro Ser Lys Pro His Phe Asn His 
545                 550                 555                 560 


Tyr Met Phe Glu Ala Ile Cys Leu Ser Ile Arg Ile Thr Cys Lys Ala 
                565                 570                 575     


Asn Pro Ala Ala Val Val Asn Phe Glu Glu Ala Leu Phe Leu Val Phe 
            580                 585                 590         


Thr Glu Ile Leu Gln Asn Asp Val Gln Glu Phe Ile Pro Tyr Val Phe 
        595                 600                 605             


Gln Val Met Ser Leu Leu Leu Glu Thr His Lys Asn Asp Ile Pro Ser 
    610                 615                 620                 


Ser Tyr Met Ala Leu Phe Pro His Leu Leu Gln Pro Val Leu Trp Glu 
625                 630                 635                 640 


Arg Thr Gly Asn Ile Pro Ala Leu Val Arg Leu Leu Gln Ala Phe Leu 
                645                 650                 655     


Glu Arg Gly Ser Asn Thr Ile Ala Ser Ala Ala Ala Asp Lys Ile Pro 
            660                 665                 670         


Gly Leu Leu Gly Val Phe Gln Lys Leu Ile Ala Ser Lys Ala Asn Asp 
        675                 680                 685             


His Gln Gly Phe Tyr Leu Leu Asn Ser Ile Ile Glu His Met Pro Pro 
    690                 695                 700                 


Glu Ser Val Asp Gln Tyr Arg Lys Gln Ile Phe Ile Leu Leu Phe Gln 
705                 710                 715                 720 


Arg Leu Gln Asn Ser Lys Thr Thr Lys Phe Ile Lys Ser Phe Leu Val 
                725                 730                 735     


Phe Ile Asn Leu Tyr Cys Ile Lys Tyr Gly Ala Leu Ala Leu Gln Glu 
            740                 745                 750         


Ile Phe Asp Gly Ile Gln Pro Lys Met Phe Gly Met Val Leu Glu Lys 
        755                 760                 765             


Ile Ile Ile Pro Glu Ile Gln Lys Val Ser Gly Asn Val Glu Lys Lys 
    770                 775                 780                 


Ile Cys Ala Val Gly Ile Thr Lys Leu Leu Thr Glu Cys Pro Pro Met 
785                 790                 795                 800 


Met Asp Thr Glu Tyr Thr Lys Leu Trp Thr Pro Leu Leu Gln Ser Leu 
                805                 810                 815     


Ile Gly Leu Phe Glu Leu Pro Glu Asp Asp Thr Ile Pro Asp Glu Glu 
            820                 825                 830         


His Phe Ile Asp Ile Glu Asp Thr Pro Gly Tyr Gln Thr Ala Phe Ser 
        835                 840                 845             


Gln Leu Ala Phe Ala Gly Lys Lys Glu His Asp Pro Val Gly Gln Met 
    850                 855                 860                 


Val Asn Asn Pro Lys Ile His Leu Ala Gln Ser Leu His Lys Leu Ser 
865                 870                 875                 880 


Thr Ala Cys Pro Gly Arg Val Pro Ser Met Val Ser Thr Ser Leu Asn 
                885                 890                 895     


Ala Glu Ala Leu Gln Tyr Leu Gln Gly Tyr Leu Gln Ala Ala Ser Val 
            900                 905                 910         


Thr Leu Leu 
        915 


<210>  2630
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF1R__Homo_sapiens__NP_005202

<400>  2630

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  2631
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2__Homo_sapiens__NP_000749

<400>  2631

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  2632
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2RA__Homo_sapiens__NP_001155002

<400>  2632

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser His Ser Val 
305                 310                 315                 320 


Thr Gln Ala Gly Val Gln Trp His Asn Leu Gly Ser Leu Gln Pro Pro 
                325                 330                 335     


Ser Pro Arg Leu Lys Arg Phe Ser Cys Leu Arg Leu Pro Gly Ser Asp 
            340                 345                 350         


Asp Gly Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly 
        355                 360                 365             


Thr Leu Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu 
    370                 375                 380                 


Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu 
385                 390                 395                 400 


Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr 
                405                 410                 415     


Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu 
            420                 425                 430         


Ile Thr 
        


<210>  2633
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF2RB__Homo_sapiens__NP_000386

<400>  2633

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 
865                 870                 875                 880 


Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 
                885                 890                 895     


Cys 
    


<210>  2634
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSF3__Homo_sapiens__NP_000750

<400>  2634

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  2635
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSGALNACT1__Homo_sapiens__NP_001123990

<400>  2635

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  2636
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSGALNACT2__Homo_sapiens__NP_061060

<400>  2636

Met Pro Arg Arg Gly Leu Ile Leu His Thr Arg Thr His Trp Leu Leu 
1               5                   10                  15      


Leu Gly Leu Ala Leu Leu Cys Ser Leu Val Leu Phe Met Tyr Leu Leu 
            20                  25                  30          


Glu Cys Ala Pro Gln Thr Asp Gly Asn Ala Ser Leu Pro Gly Val Val 
        35                  40                  45              


Gly Glu Asn Tyr Gly Lys Glu Tyr Tyr Gln Ala Leu Leu Gln Glu Gln 
    50                  55                  60                  


Glu Glu His Tyr Gln Thr Arg Ala Thr Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Gln Glu Leu Gln Glu Met Ser Glu Lys Met Arg Ser Leu 
                85                  90                  95      


Gln Glu Arg Arg Asn Val Gly Ala Asn Gly Ile Gly Tyr Gln Ser Asn 
            100                 105                 110         


Lys Glu Gln Ala Pro Ser Asp Leu Leu Glu Phe Leu His Ser Gln Ile 
        115                 120                 125             


Asp Lys Ala Glu Val Ser Ile Gly Ala Lys Leu Pro Ser Glu Tyr Gly 
    130                 135                 140                 


Val Ile Pro Phe Glu Ser Phe Thr Leu Met Lys Val Phe Gln Leu Glu 
145                 150                 155                 160 


Met Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Val Ile Glu Ala Gly Leu Glu Val Ile Asn 
            180                 185                 190         


Asn Pro Asp Glu Asp Asp Glu Gln Glu Asp Glu Glu Gly Pro Leu Gly 
        195                 200                 205             


Glu Lys Leu Ile Phe Asn Glu Asn Asp Phe Val Glu Gly Tyr Tyr Arg 
    210                 215                 220                 


Thr Glu Arg Asp Lys Gly Thr Gln Tyr Glu Leu Phe Phe Lys Lys Ala 
225                 230                 235                 240 


Asp Leu Thr Glu Tyr Arg His Val Thr Leu Phe Arg Pro Phe Gly Pro 
                245                 250                 255     


Leu Met Lys Val Lys Ser Glu Met Ile Asp Ile Thr Arg Ser Ile Ile 
            260                 265                 270         


Asn Ile Ile Val Pro Leu Ala Glu Arg Thr Glu Ala Phe Val Gln Phe 
        275                 280                 285             


Met Gln Asn Phe Arg Asp Val Cys Ile His Gln Asp Lys Lys Ile His 
    290                 295                 300                 


Leu Thr Val Val Tyr Phe Gly Lys Glu Gly Leu Ser Lys Val Lys Ser 
305                 310                 315                 320 


Ile Leu Glu Ser Val Thr Ser Glu Ser Asn Phe His Asn Tyr Thr Leu 
                325                 330                 335     


Val Ser Leu Asn Glu Glu Phe Asn Arg Gly Arg Gly Leu Asn Val Gly 
            340                 345                 350         


Ala Arg Ala Trp Asp Lys Gly Glu Val Leu Met Phe Phe Cys Asp Val 
        355                 360                 365             


Asp Ile Tyr Phe Ser Ala Glu Phe Leu Asn Ser Cys Arg Leu Asn Ala 
    370                 375                 380                 


Glu Pro Gly Lys Lys Val Phe Tyr Pro Val Val Phe Ser Leu Tyr Asn 
385                 390                 395                 400 


Pro Ala Ile Val Tyr Ala Asn Gln Glu Val Pro Pro Pro Val Glu Gln 
                405                 410                 415     


Gln Leu Val His Lys Lys Asp Ser Gly Phe Trp Arg Asp Phe Gly Phe 
            420                 425                 430         


Gly Met Thr Cys Gln Tyr Arg Ser Asp Phe Leu Thr Ile Gly Gly Phe 
        435                 440                 445             


Asp Met Glu Val Lys Gly Trp Gly Gly Glu Asp Val His Leu Tyr Arg 
    450                 455                 460                 


Lys Tyr Leu His Gly Asp Leu Ile Val Ile Arg Thr Pro Val Pro Gly 
465                 470                 475                 480 


Leu Phe His Leu Trp His Glu Lys Arg Cys Ala Asp Glu Leu Thr Pro 
                485                 490                 495     


Glu Gln Tyr Arg Met Cys Ile Gln Ser Lys Ala Met Asn Glu Ala Ser 
            500                 505                 510         


His Ser His Leu Gly Met Leu Val Phe Arg Glu Glu Ile Glu Thr His 
        515                 520                 525             


Leu His Lys Gln Ala Tyr Arg Thr Asn Ser Glu Ala Val Gly 
    530                 535                 540         


<210>  2637
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSH1__Homo_sapiens__NP_001308

<400>  2637

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  2638
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSH2__Homo_sapiens__NP_066271

<400>  2638

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Arg Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  2639
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSHL1__Homo_sapiens__NP_001309

<400>  2639

Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser 
1               5                   10                  15      


Leu Leu Leu Ile Glu Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser 
            20                  25                  30          


Thr Phe Thr Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr 
        35                  40                  45              


His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu Met Gly Arg 
    50                  55                  60                  


Leu Glu Asp Gly Ser His Leu Thr Gly Gln Thr Leu Lys Gln Thr Tyr 
65                  70                  75                  80  


Ser Lys Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn 
                85                  90                  95      


Tyr Gly Leu Leu His Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr 
            100                 105                 110         


Phe Leu Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
        115                 120                 125             


<210>  2640
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS__Homo_sapiens__NP_004068

<400>  2640

Met Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala 
1               5                   10                  15      


Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Ala Ser Ser Thr Asn 
            20                  25                  30          


Leu Lys Asp Ile Leu Ala Asp Leu Ile Pro Lys Glu Gln Ala Arg Ile 
        35                  40                  45              


Lys Thr Phe Arg Gln Gln His Gly Lys Thr Val Val Gly Gln Ile Thr 
    50                  55                  60                  


Val Asp Met Met Tyr Gly Gly Met Arg Gly Met Lys Gly Leu Val Tyr 
65                  70                  75                  80  


Glu Thr Ser Val Leu Asp Pro Asp Glu Gly Ile Arg Phe Arg Gly Phe 
                85                  90                  95      


Ser Ile Pro Glu Cys Gln Lys Leu Leu Pro Lys Ala Lys Gly Gly Glu 
            100                 105                 110         


Glu Pro Leu Pro Glu Gly Leu Phe Trp Leu Leu Val Thr Gly His Ile 
        115                 120                 125             


Pro Thr Glu Glu Gln Val Ser Trp Leu Ser Lys Glu Trp Ala Lys Arg 
    130                 135                 140                 


Ala Ala Leu Pro Ser His Val Val Thr Met Leu Asp Asn Phe Pro Thr 
145                 150                 155                 160 


Asn Leu His Pro Met Ser Gln Leu Ser Ala Ala Val Thr Ala Leu Asn 
                165                 170                 175     


Ser Glu Ser Asn Phe Ala Arg Ala Tyr Ala Gln Gly Ile Ser Arg Thr 
            180                 185                 190         


Lys Tyr Trp Glu Leu Ile Tyr Glu Asp Ser Met Asp Leu Ile Ala Lys 
        195                 200                 205             


Leu Pro Cys Val Ala Ala Lys Ile Tyr Arg Asn Leu Tyr Arg Glu Gly 
    210                 215                 220                 


Ser Gly Ile Gly Ala Ile Asp Ser Asn Leu Asp Trp Ser His Asn Phe 
225                 230                 235                 240 


Thr Asn Met Leu Gly Tyr Thr Asp His Gln Phe Thr Glu Leu Thr Arg 
                245                 250                 255     


Leu Tyr Leu Thr Ile His Ser Asp His Glu Gly Gly Asn Val Ser Ala 
            260                 265                 270         


His Thr Ser His Leu Val Gly Ser Ala Leu Ser Asp Pro Tyr Leu Ser 
        275                 280                 285             


Phe Ala Ala Ala Met Asn Gly Leu Ala Gly Pro Leu His Gly Leu Ala 
    290                 295                 300                 


Asn Gln Glu Val Leu Val Trp Leu Thr Gln Leu Gln Lys Glu Val Gly 
305                 310                 315                 320 


Lys Asp Val Ser Asp Glu Lys Leu Arg Asp Tyr Ile Trp Asn Thr Leu 
                325                 330                 335     


Asn Ser Gly Arg Val Val Pro Gly Tyr Gly His Ala Val Leu Arg Lys 
            340                 345                 350         


Thr Asp Pro Arg Tyr Thr Cys Gln Arg Glu Phe Ala Leu Lys His Leu 
        355                 360                 365             


Pro Asn Asp Pro Met Phe Lys Leu Val Ala Gln Leu Tyr Lys Ile Val 
    370                 375                 380                 


Pro Asn Val Leu Leu Glu Gln Gly Lys Ala Lys Asn Pro Trp Pro Asn 
385                 390                 395                 400 


Val Asp Ala His Ser Gly Val Leu Leu Gln Tyr Tyr Gly Met Thr Glu 
                405                 410                 415     


Met Asn Tyr Tyr Thr Val Leu Phe Gly Val Ser Arg Ala Leu Gly Val 
            420                 425                 430         


Leu Ala Gln Leu Ile Trp Ser Arg Ala Leu Gly Phe Pro Leu Glu Arg 
        435                 440                 445             


Pro Lys Ser Met Ser Thr Glu Gly Leu Met Lys Phe Val Asp Ser Lys 
    450                 455                 460                 


Ser Gly 
465     


<210>  2641
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSK__Homo_sapiens__XP_005254222

<400>  2641

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  2642
<211>  3564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSMD1__Homo_sapiens__NP_150094

<400>  2642

Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys 
            20                  25                  30          


Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe 
        35                  40                  45              


Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr 
    50                  55                  60                  


Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu 
65                  70                  75                  80  


Glu Asp Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly 
                85                  90                  95      


Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val 
            100                 105                 110         


Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val 
        115                 120                 125             


Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr 
    130                 135                 140                 


Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg 
145                 150                 155                 160 


Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile 
                165                 170                 175     


Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly 
            180                 185                 190         


Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys 
        195                 200                 205             


Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe 
    210                 215                 220                 


Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala 
225                 230                 235                 240 


Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu 
                245                 250                 255     


Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile 
            260                 265                 270         


Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn 
        275                 280                 285             


Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly 
    290                 295                 300                 


Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg 
305                 310                 315                 320 


Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val 
                325                 330                 335     


Leu Ser Gln Gly Gly Val Ala Leu Val Ser Asp Met Cys Pro Asp Pro 
            340                 345                 350         


Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Arg Val Gly 
        355                 360                 365             


Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly Ser 
    370                 375                 380                 


Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp Ser 
385                 390                 395                 400 


Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu Arg 
                405                 410                 415     


Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr Glu 
            420                 425                 430         


Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp Lys 
        435                 440                 445             


Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr Asp 
    450                 455                 460                 


Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser Val 
465                 470                 475                 480 


Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser Met 
                485                 490                 495     


Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly Ser 
            500                 505                 510         


Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys Gly 
        515                 520                 525             


Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe Leu 
    530                 535                 540                 


His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu Val 
545                 550                 555                 560 


Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly Asn 
                565                 570                 575     


Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser Ser 
            580                 585                 590         


Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn Met 
        595                 600                 605             


Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His Leu 
    610                 615                 620                 


Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala Val 
625                 630                 635                 640 


Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser Gly 
                645                 650                 655     


Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg Leu 
            660                 665                 670         


Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile Thr 
        675                 680                 685             


Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro Ile 
    690                 695                 700                 


Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val Ser 
705                 710                 715                 720 


Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser Ile 
                725                 730                 735     


Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val Pro 
            740                 745                 750         


Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly Val 
        755                 760                 765             


Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His Cys 
    770                 775                 780                 


Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe 
785                 790                 795                 800 


Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp 
                805                 810                 815     


Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln 
            820                 825                 830         


Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe 
        835                 840                 845             


Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu 
    850                 855                 860                 


Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val 
865                 870                 875                 880 


Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr 
                885                 890                 895     


Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val 
            900                 905                 910         


Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp Ala 
        915                 920                 925             


Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro 
    930                 935                 940                 


Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile 
945                 950                 955                 960 


Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe His 
                965                 970                 975     


Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe 
            980                 985                 990         


Ser Glu Pro Val Ala Arg Leu Thr  Gly Ser Val Leu Pro  His Thr Ile 
        995                 1000                 1005             


Lys Ala  Gly Leu Phe Gly Asn  Phe Thr Ala Gln Leu  Arg Phe Ile 
    1010                 1015                 1020             


Ser Asp  Phe Ser Ile Ser Tyr  Glu Gly Phe Asn Ile  Thr Phe Ser 
    1025                 1030                 1035             


Glu Tyr  Asp Leu Glu Pro Cys  Asp Asp Pro Gly Val  Pro Ala Phe 
    1040                 1045                 1050             


Ser Arg  Arg Ile Gly Phe His  Phe Gly Val Gly Asp  Ser Leu Thr 
    1055                 1060                 1065             


Phe Ser  Cys Phe Leu Gly Tyr  Arg Leu Glu Gly Ala  Thr Lys Leu 
    1070                 1075                 1080             


Thr Cys  Leu Gly Gly Gly Arg  Arg Val Trp Ser Ala  Pro Leu Pro 
    1085                 1090                 1095             


Arg Cys  Val Ala Glu Cys Gly  Ala Ser Val Lys Gly  Asn Glu Gly 
    1100                 1105                 1110             


Thr Leu  Leu Ser Pro Asn Phe  Pro Ser Asn Tyr Asp  Asn Asn His 
    1115                 1120                 1125             


Glu Cys  Ile Tyr Lys Ile Glu  Thr Glu Ala Gly Lys  Gly Ile His 
    1130                 1135                 1140             


Leu Arg  Thr Arg Ser Phe Gln  Leu Phe Glu Gly Asp  Thr Leu Lys 
    1145                 1150                 1155             


Val Tyr  Asp Gly Lys Asp Ser  Ser Ser Arg Pro Leu  Gly Thr Phe 
    1160                 1165                 1170             


Thr Lys  Asn Glu Leu Leu Gly  Leu Ile Leu Asn Ser  Thr Ser Asn 
    1175                 1180                 1185             


His Leu  Trp Leu Glu Phe Asn  Thr Asn Gly Ser Asp  Thr Asp Gln 
    1190                 1195                 1200             


Gly Phe  Gln Leu Thr Tyr Thr  Ser Phe Asp Leu Val  Lys Cys Glu 
    1205                 1210                 1215             


Asp Pro  Gly Ile Pro Asn Tyr  Gly Tyr Arg Ile Arg  Asp Glu Gly 
    1220                 1225                 1230             


His Phe  Thr Asp Thr Val Val  Leu Tyr Ser Cys Asn  Pro Gly Tyr 
    1235                 1240                 1245             


Ala Met  His Gly Ser Asn Thr  Leu Thr Cys Leu Ser  Gly Asp Arg 
    1250                 1255                 1260             


Arg Val  Trp Asp Lys Pro Leu  Pro Ser Cys Ile Ala  Glu Cys Gly 
    1265                 1270                 1275             


Gly Gln  Ile His Ala Ala Thr  Ser Gly Arg Ile Leu  Ser Pro Gly 
    1280                 1285                 1290             


Tyr Pro  Ala Pro Tyr Asp Asn  Asn Leu His Cys Thr  Trp Ile Ile 
    1295                 1300                 1305             


Glu Ala  Asp Pro Gly Lys Thr  Ile Ser Leu His Phe  Ile Val Phe 
    1310                 1315                 1320             


Asp Thr  Glu Met Ala His Asp  Ile Leu Lys Val Trp  Asp Gly Pro 
    1325                 1330                 1335             


Val Asp  Ser Asp Ile Leu Leu  Lys Glu Trp Ser Gly  Ser Ala Leu 
    1340                 1345                 1350             


Pro Glu  Asp Ile His Ser Thr  Phe Asn Ser Leu Thr  Leu Gln Phe 
    1355                 1360                 1365             


Asp Ser  Asp Phe Phe Ile Ser  Lys Ser Gly Phe Ser  Ile Gln Phe 
    1370                 1375                 1380             


Ser Thr  Ser Ile Ala Ala Thr  Cys Asn Asp Pro Gly  Met Pro Gln 
    1385                 1390                 1395             


Asn Gly  Thr Arg Tyr Gly Asp  Ser Arg Glu Ala Gly  Asp Thr Val 
    1400                 1405                 1410             


Thr Phe  Gln Cys Asp Pro Gly  Tyr Gln Leu Gln Gly  Gln Ala Lys 
    1415                 1420                 1425             


Ile Thr  Cys Val Gln Leu Asn  Asn Arg Phe Phe Trp  Gln Pro Asp 
    1430                 1435                 1440             


Pro Pro  Thr Cys Ile Ala Ala  Cys Gly Gly Asn Leu  Thr Gly Pro 
    1445                 1450                 1455             


Ala Gly  Val Ile Leu Ser Pro  Asn Tyr Pro Gln Pro  Tyr Pro Pro 
    1460                 1465                 1470             


Gly Lys  Glu Cys Asp Trp Arg  Val Lys Val Asn Pro  Asp Phe Val 
    1475                 1480                 1485             


Ile Ala  Leu Ile Phe Lys Ser  Phe Asn Met Glu Pro  Ser Tyr Asp 
    1490                 1495                 1500             


Phe Leu  His Ile Tyr Glu Gly  Glu Asp Ser Asn Ser  Pro Leu Ile 
    1505                 1510                 1515             


Gly Ser  Tyr Gln Gly Ser Gln  Ala Pro Glu Arg Ile  Glu Ser Ser 
    1520                 1525                 1530             


Gly Asn  Ser Leu Phe Leu Ala  Phe Arg Ser Asp Ala  Ser Val Gly 
    1535                 1540                 1545             


Leu Ser  Gly Phe Ala Ile Glu  Phe Lys Glu Lys Pro  Arg Glu Ala 
    1550                 1555                 1560             


Cys Phe  Asp Pro Gly Asn Ile  Met Asn Gly Thr Arg  Val Gly Thr 
    1565                 1570                 1575             


Asp Phe  Lys Leu Gly Ser Thr  Ile Thr Tyr Gln Cys  Asp Ser Gly 
    1580                 1585                 1590             


Tyr Lys  Ile Leu Asp Pro Ser  Ser Ile Thr Cys Val  Ile Gly Ala 
    1595                 1600                 1605             


Asp Gly  Lys Pro Ser Trp Asp  Gln Val Leu Pro Ser  Cys Asn Ala 
    1610                 1615                 1620             


Pro Cys  Gly Gly Gln Tyr Thr  Gly Ser Glu Gly Val  Val Leu Ser 
    1625                 1630                 1635             


Pro Asn  Tyr Pro His Asn Tyr  Thr Ala Gly Gln Ile  Cys Leu Tyr 
    1640                 1645                 1650             


Ser Ile  Thr Val Pro Lys Glu  Phe Val Val Phe Gly  Gln Phe Ala 
    1655                 1660                 1665             


Tyr Phe  Gln Thr Ala Leu Asn  Asp Leu Ala Glu Leu  Phe Asp Gly 
    1670                 1675                 1680             


Thr His  Ala Gln Ala Arg Leu  Leu Ser Ser Leu Ser  Gly Ser His 
    1685                 1690                 1695             


Ser Gly  Glu Thr Leu Pro Leu  Ala Thr Ser Asn Gln  Ile Leu Leu 
    1700                 1705                 1710             


Arg Phe  Ser Ala Lys Ser Gly  Ala Ser Ala Arg Gly  Phe His Phe 
    1715                 1720                 1725             


Val Tyr  Gln Ala Val Pro Arg  Thr Ser Asp Thr Gln  Cys Ser Ser 
    1730                 1735                 1740             


Val Pro  Glu Pro Arg Tyr Gly  Arg Arg Ile Gly Ser  Glu Phe Ser 
    1745                 1750                 1755             


Ala Gly  Ser Ile Val Arg Phe  Glu Cys Asn Pro Gly  Tyr Leu Leu 
    1760                 1765                 1770             


Gln Gly  Ser Thr Ala Leu His  Cys Gln Ser Val Pro  Asn Ala Leu 
    1775                 1780                 1785             


Ala Gln  Trp Asn Asp Thr Ile  Pro Ser Cys Val Val  Pro Cys Ser 
    1790                 1795                 1800             


Gly Asn  Phe Thr Gln Arg Arg  Gly Thr Ile Leu Ser  Pro Gly Tyr 
    1805                 1810                 1815             


Pro Glu  Pro Tyr Gly Asn Asn  Leu Asn Cys Ile Trp  Lys Ile Ile 
    1820                 1825                 1830             


Val Thr  Glu Gly Ser Gly Ile  Gln Ile Gln Val Ile  Ser Phe Ala 
    1835                 1840                 1845             


Thr Glu  Gln Asn Trp Asp Ser  Leu Glu Ile His Asp  Gly Gly Asp 
    1850                 1855                 1860             


Val Thr  Ala Pro Arg Leu Gly  Ser Phe Ser Gly Thr  Thr Val Pro 
    1865                 1870                 1875             


Ala Leu  Leu Asn Ser Thr Ser  Asn Gln Leu Tyr Leu  His Phe Gln 
    1880                 1885                 1890             


Ser Asp  Ile Ser Val Ala Ala  Ala Gly Phe His Leu  Glu Tyr Lys 
    1895                 1900                 1905             


Thr Val  Gly Leu Ala Ala Cys  Gln Glu Pro Ala Leu  Pro Ser Asn 
    1910                 1915                 1920             


Ser Ile  Lys Ile Gly Asp Arg  Tyr Met Val Asn Asp  Val Leu Ser 
    1925                 1930                 1935             


Phe Gln  Cys Glu Pro Gly Tyr  Thr Leu Gln Gly Arg  Ser His Ile 
    1940                 1945                 1950             


Ser Cys  Met Pro Gly Thr Val  Arg Arg Trp Asn Tyr  Pro Ser Pro 
    1955                 1960                 1965             


Leu Cys  Ile Ala Thr Cys Gly  Gly Thr Leu Ser Thr  Leu Gly Gly 
    1970                 1975                 1980             


Val Ile  Leu Ser Pro Gly Phe  Pro Gly Ser Tyr Pro  Asn Asn Leu 
    1985                 1990                 1995             


Asp Cys  Thr Trp Arg Ile Ser  Leu Pro Ile Gly Tyr  Gly Ala His 
    2000                 2005                 2010             


Ile Gln  Phe Leu Asn Phe Ser  Thr Glu Ala Asn His  Asp Phe Leu 
    2015                 2020                 2025             


Glu Ile  Gln Asn Gly Pro Tyr  His Thr Ser Pro Met  Ile Gly Gln 
    2030                 2035                 2040             


Phe Ser  Gly Thr Asp Leu Pro  Ala Ala Leu Leu Ser  Thr Thr His 
    2045                 2050                 2055             


Glu Thr  Leu Ile His Phe Tyr  Ser Asp His Ser Gln  Asn Arg Gln 
    2060                 2065                 2070             


Gly Phe  Lys Leu Ala Tyr Gln  Ala Tyr Glu Leu Gln  Asn Cys Pro 
    2075                 2080                 2085             


Asp Pro  Pro Pro Phe Gln Asn  Gly Tyr Met Ile Asn  Ser Asp Tyr 
    2090                 2095                 2100             


Ser Val  Gly Gln Ser Val Ser  Phe Glu Cys Tyr Pro  Gly Tyr Ile 
    2105                 2110                 2115             


Leu Ile  Gly His Pro Val Leu  Thr Cys Gln His Gly  Ile Asn Arg 
    2120                 2125                 2130             


Asn Trp  Asn Tyr Pro Phe Pro  Arg Cys Asp Ala Pro  Cys Gly Tyr 
    2135                 2140                 2145             


Asn Val  Thr Ser Gln Asn Gly  Thr Ile Tyr Ser Pro  Gly Phe Pro 
    2150                 2155                 2160             


Asp Glu  Tyr Pro Ile Leu Lys  Asp Cys Ile Trp Leu  Ile Thr Val 
    2165                 2170                 2175             


Pro Pro  Gly His Gly Val Tyr  Ile Asn Phe Thr Leu  Leu Gln Thr 
    2180                 2185                 2190             


Glu Ala  Val Asn Asp Tyr Ile  Ala Val Trp Asp Gly  Pro Asp Gln 
    2195                 2200                 2205             


Asn Ser  Pro Gln Leu Gly Val  Phe Ser Gly Asn Thr  Ala Leu Glu 
    2210                 2215                 2220             


Thr Ala  Tyr Ser Ser Thr Asn  Gln Val Leu Leu Lys  Phe His Ser 
    2225                 2230                 2235             


Asp Phe  Ser Asn Gly Gly Phe  Phe Val Leu Asn Phe  His Ala Phe 
    2240                 2245                 2250             


Gln Leu  Lys Lys Cys Gln Pro  Pro Pro Ala Val Pro  Gln Ala Glu 
    2255                 2260                 2265             


Met Leu  Thr Glu Asp Asp Asp  Phe Glu Ile Gly Asp  Phe Val Lys 
    2270                 2275                 2280             


Tyr Gln  Cys His Pro Gly Tyr  Thr Leu Val Gly Thr  Asp Ile Leu 
    2285                 2290                 2295             


Thr Cys  Lys Leu Ser Ser Gln  Leu Gln Phe Glu Gly  Ser Leu Pro 
    2300                 2305                 2310             


Thr Cys  Glu Ala Gln Cys Pro  Ala Asn Glu Val Arg  Thr Gly Ser 
    2315                 2320                 2325             


Ser Gly  Val Ile Leu Ser Pro  Gly Tyr Pro Gly Asn  Tyr Phe Asn 
    2330                 2335                 2340             


Ser Gln  Thr Cys Ser Trp Ser  Ile Lys Val Glu Pro  Asn Tyr Asn 
    2345                 2350                 2355             


Ile Thr  Ile Phe Val Asp Thr  Phe Gln Ser Glu Lys  Gln Phe Asp 
    2360                 2365                 2370             


Ala Leu  Glu Val Phe Asp Gly  Ser Ser Gly Gln Ser  Pro Leu Leu 
    2375                 2380                 2385             


Val Val  Leu Ser Gly Asn His  Thr Glu Gln Ser Asn  Phe Thr Ser 
    2390                 2395                 2400             


Arg Ser  Asn Gln Leu Tyr Leu  Arg Trp Ser Thr Asp  His Ala Thr 
    2405                 2410                 2415             


Ser Lys  Lys Gly Phe Lys Ile  Arg Tyr Ala Ala Pro  Tyr Cys Ser 
    2420                 2425                 2430             


Leu Thr  His Pro Leu Lys Asn  Gly Gly Ile Leu Asn  Arg Thr Ala 
    2435                 2440                 2445             


Gly Ala  Val Gly Ser Lys Val  His Tyr Phe Cys Lys  Pro Gly Tyr 
    2450                 2455                 2460             


Arg Met  Val Gly His Ser Asn  Ala Thr Cys Arg Arg  Asn Pro Leu 
    2465                 2470                 2475             


Gly Met  Tyr Gln Trp Asp Ser  Leu Thr Pro Leu Cys  Gln Ala Val 
    2480                 2485                 2490             


Ser Cys  Gly Ile Pro Glu Ser  Pro Gly Asn Gly Ser  Phe Thr Gly 
    2495                 2500                 2505             


Asn Glu  Phe Thr Leu Asp Ser  Lys Val Val Tyr Glu  Cys His Glu 
    2510                 2515                 2520             


Gly Phe  Lys Leu Glu Ser Ser  Gln Gln Ala Thr Ala  Val Cys Gln 
    2525                 2530                 2535             


Glu Asp  Gly Leu Trp Ser Asn  Lys Gly Lys Pro Pro  Thr Cys Lys 
    2540                 2545                 2550             


Pro Val  Ala Cys Pro Ser Ile  Glu Ala Gln Leu Ser  Glu His Val 
    2555                 2560                 2565             


Ile Trp  Arg Leu Val Ser Gly  Ser Leu Asn Glu Tyr  Gly Ala Gln 
    2570                 2575                 2580             


Val Leu  Leu Ser Cys Ser Pro  Gly Tyr Tyr Leu Glu  Gly Trp Arg 
    2585                 2590                 2595             


Leu Leu  Arg Cys Gln Ala Asn  Gly Thr Trp Asn Ile  Gly Asp Glu 
    2600                 2605                 2610             


Arg Pro  Ser Cys Arg Val Ile  Ser Cys Gly Ser Leu  Ser Phe Pro 
    2615                 2620                 2625             


Pro Asn  Gly Asn Lys Ile Gly  Thr Leu Thr Val Tyr  Gly Ala Thr 
    2630                 2635                 2640             


Ala Ile  Phe Thr Cys Asn Thr  Gly Tyr Thr Leu Val  Gly Ser His 
    2645                 2650                 2655             


Val Arg  Glu Cys Leu Ala Asn  Gly Leu Trp Ser Gly  Ser Glu Thr 
    2660                 2665                 2670             


Arg Cys  Leu Ala Gly His Cys  Gly Ser Pro Asp Pro  Ile Val Asn 
    2675                 2680                 2685             


Gly His  Ile Ser Gly Asp Gly  Phe Ser Tyr Arg Asp  Thr Val Val 
    2690                 2695                 2700             


Tyr Gln  Cys Asn Pro Gly Phe  Arg Leu Val Gly Thr  Ser Val Arg 
    2705                 2710                 2715             


Ile Cys  Leu Gln Asp His Lys  Trp Ser Gly Gln Thr  Pro Val Cys 
    2720                 2725                 2730             


Val Pro  Ile Thr Cys Gly His  Pro Gly Asn Pro Ala  His Gly Phe 
    2735                 2740                 2745             


Thr Asn  Gly Ser Glu Phe Asn  Leu Asn Asp Val Val  Asn Phe Thr 
    2750                 2755                 2760             


Cys Asn  Thr Gly Tyr Leu Leu  Gln Gly Val Ser Arg  Ala Gln Cys 
    2765                 2770                 2775             


Arg Ser  Asn Gly Gln Trp Ser  Ser Pro Leu Pro Thr  Cys Arg Val 
    2780                 2785                 2790             


Val Asn  Cys Ser Asp Pro Gly  Phe Val Glu Asn Ala  Ile Arg His 
    2795                 2800                 2805             


Gly Gln  Gln Asn Phe Pro Glu  Ser Phe Glu Tyr Gly  Met Ser Ile 
    2810                 2815                 2820             


Leu Tyr  His Cys Lys Lys Gly  Phe Tyr Leu Leu Gly  Ser Ser Ala 
    2825                 2830                 2835             


Leu Thr  Cys Met Ala Asn Gly  Leu Trp Asp Arg Ser  Leu Pro Lys 
    2840                 2845                 2850             


Cys Leu  Ala Ile Ser Cys Gly  His Pro Gly Val Pro  Ala Asn Ala 
    2855                 2860                 2865             


Val Leu  Thr Gly Glu Leu Phe  Thr Tyr Gly Ala Val  Val His Tyr 
    2870                 2875                 2880             


Ser Cys  Arg Gly Ser Glu Ser  Leu Ile Gly Asn Asp  Thr Arg Val 
    2885                 2890                 2895             


Cys Gln  Glu Asp Ser His Trp  Ser Gly Ala Leu Pro  His Cys Thr 
    2900                 2905                 2910             


Gly Asn  Asn Pro Gly Phe Cys  Gly Asp Pro Gly Thr  Pro Ala His 
    2915                 2920                 2925             


Gly Ser  Arg Leu Gly Asp Asp  Phe Lys Thr Lys Ser  Leu Leu Arg 
    2930                 2935                 2940             


Phe Ser  Cys Glu Met Gly His  Gln Leu Arg Gly Ser  Pro Glu Arg 
    2945                 2950                 2955             


Thr Cys  Leu Leu Asn Gly Ser  Trp Ser Gly Leu Gln  Pro Val Cys 
    2960                 2965                 2970             


Glu Ala  Val Ser Cys Gly Asn  Pro Gly Thr Pro Thr  Asn Gly Met 
    2975                 2980                 2985             


Ile Val  Ser Ser Asp Gly Ile  Leu Phe Ser Ser Ser  Val Ile Tyr 
    2990                 2995                 3000             


Ala Cys  Trp Glu Gly Tyr Lys  Thr Ser Gly Leu Met  Thr Arg His 
    3005                 3010                 3015             


Cys Thr  Ala Asn Gly Thr Trp  Thr Gly Thr Ala Pro  Asp Cys Thr 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Asp Pro  Gly Thr Leu Ala Asn  Gly Ile Gln 
    3035                 3040                 3045             


Phe Gly  Thr Asp Phe Thr Phe  Asn Lys Thr Val Ser  Tyr Gln Cys 
    3050                 3055                 3060             


Asn Pro  Gly Tyr Val Met Glu  Ala Val Thr Ser Ala  Thr Ile Arg 
    3065                 3070                 3075             


Cys Thr  Lys Asp Gly Arg Trp  Asn Pro Ser Lys Pro  Val Cys Lys 
    3080                 3085                 3090             


Ala Val  Leu Cys Pro Gln Pro  Pro Pro Val Gln Asn  Gly Thr Val 
    3095                 3100                 3105             


Glu Gly  Ser Asp Phe Arg Trp  Gly Ser Ser Ile Ser  Tyr Ser Cys 
    3110                 3115                 3120             


Met Asp  Gly Tyr Gln Leu Ser  His Ser Ala Ile Leu  Ser Cys Glu 
    3125                 3130                 3135             


Gly Arg  Gly Val Trp Lys Gly  Glu Ile Pro Gln Cys  Leu Pro Val 
    3140                 3145                 3150             


Phe Cys  Gly Asp Pro Gly Ile  Pro Ala Glu Gly Arg  Leu Ser Gly 
    3155                 3160                 3165             


Lys Ser  Phe Thr Tyr Lys Ser  Glu Val Phe Phe Gln  Cys Lys Ser 
    3170                 3175                 3180             


Pro Phe  Ile Leu Val Gly Ser  Ser Arg Arg Val Cys  Gln Ala Asp 
    3185                 3190                 3195             


Gly Thr  Trp Ser Gly Ile Gln  Pro Thr Cys Ile Asp  Pro Ala His 
    3200                 3205                 3210             


Asn Thr  Cys Pro Asp Pro Gly  Thr Pro His Phe Gly  Ile Gln Asn 
    3215                 3220                 3225             


Ser Ser  Arg Gly Tyr Glu Val  Gly Ser Thr Val Phe  Phe Arg Cys 
    3230                 3235                 3240             


Arg Lys  Gly Tyr His Ile Gln  Gly Ser Thr Thr Arg  Thr Cys Leu 
    3245                 3250                 3255             


Ala Asn  Leu Thr Trp Ser Gly  Ile Gln Thr Glu Cys  Ile Pro His 
    3260                 3265                 3270             


Ala Cys  Arg Gln Pro Glu Thr  Pro Ala His Ala Asp  Val Arg Ala 
    3275                 3280                 3285             


Ile Asp  Leu Pro Thr Phe Gly  Tyr Thr Leu Val Tyr  Thr Cys His 
    3290                 3295                 3300             


Pro Gly  Phe Phe Leu Ala Gly  Gly Ser Glu His Arg  Thr Cys Lys 
    3305                 3310                 3315             


Ala Asp  Met Lys Trp Thr Gly  Lys Ser Pro Val Cys  Lys Ser Lys 
    3320                 3325                 3330             


Gly Val  Arg Glu Val Asn Glu  Thr Val Thr Lys Thr  Pro Val Pro 
    3335                 3340                 3345             


Ser Asp  Val Phe Phe Val Asn  Ser Leu Trp Lys Gly  Tyr Tyr Glu 
    3350                 3355                 3360             


Tyr Leu  Gly Lys Arg Gln Pro  Ala Thr Leu Thr Val  Asp Trp Phe 
    3365                 3370                 3375             


Asn Ala  Thr Ser Ser Lys Val  Asn Ala Thr Phe Ser  Glu Ala Ser 
    3380                 3385                 3390             


Pro Val  Glu Leu Lys Leu Thr  Gly Ile Tyr Lys Lys  Glu Glu Ala 
    3395                 3400                 3405             


His Leu  Leu Leu Lys Ala Phe  Gln Ile Lys Gly Gln  Ala Asp Ile 
    3410                 3415                 3420             


Phe Val  Ser Lys Phe Glu Asn  Asp Asn Trp Gly Leu  Asp Gly Tyr 
    3425                 3430                 3435             


Val Ser  Ser Gly Leu Glu Arg  Gly Gly Phe Thr Phe  Gln Gly Asp 
    3440                 3445                 3450             


Ile His  Gly Lys Asp Phe Gly  Lys Phe Lys Leu Glu  Arg Gln Asp 
    3455                 3460                 3465             


Pro Leu  Asn Pro Asp Gln Asp  Ser Ser Ser His Tyr  His Gly Thr 
    3470                 3475                 3480             


Ser Ser  Gly Ser Val Ala Ala  Ala Ile Leu Val Pro  Phe Phe Ala 
    3485                 3490                 3495             


Leu Ile  Leu Ser Gly Phe Ala  Phe Tyr Leu Tyr Lys  His Arg Thr 
    3500                 3505                 3510             


Arg Pro  Lys Val Gln Tyr Asn  Gly Tyr Ala Gly His  Glu Asn Ser 
    3515                 3520                 3525             


Asn Gly  Gln Ala Ser Phe Glu  Asn Pro Met Tyr Asp  Thr Asn Leu 
    3530                 3535                 3540             


Lys Pro  Thr Glu Ala Lys Ala  Val Arg Phe Asp Thr  Thr Leu Asn 
    3545                 3550                 3555             


Thr Val  Cys Thr Val Val 
    3560                 


<210>  2643
<211>  3607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSMD2__Homo_sapiens__XP_011538874

<400>  2643

Met Pro Arg Ser Arg Gly Arg Glu Leu Gly Arg Cys Gly Cys Pro Ala 
1               5                   10                  15      


Gly Arg Ala Arg Gly Glu Thr Gly Ile Ser Ala Leu Val Pro Gly Ala 
            20                  25                  30          


Gly Ser Arg Trp Gly Arg Pro Pro Pro Pro Thr Pro Pro Pro Leu Leu 
        35                  40                  45              


Leu Leu Leu Gly Cys Gly Leu Leu Ser Val Ser Ala Ala Ala Gly Gln 
    50                  55                  60                  


Asn Cys Thr Phe Gln Leu His Gly Pro Asn Gly Thr Val Glu Ser Pro 
65                  70                  75                  80  


Gly Phe Pro Tyr Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Thr Ile 
                85                  90                  95      


Thr Ala Glu Glu Gln His Arg Ile Gln Leu Val Phe Gln Ser Phe Ala 
            100                 105                 110         


Leu Glu Glu Asp Phe Asp Val Leu Ser Val Phe Asp Gly Pro Pro Gln 
        115                 120                 125             


Pro Glu Asn Leu Arg Thr Arg Leu Thr Gly Phe Gln Leu Pro Ala Thr 
    130                 135                 140                 


Ile Val Ser Ala Ala Thr Thr Leu Ser Leu Arg Leu Ile Ser Asp Tyr 
145                 150                 155                 160 


Ala Val Ser Ala Gln Gly Phe His Ala Thr Tyr Glu Val Leu Pro Ser 
                165                 170                 175     


His Thr Cys Gly Asn Pro Gly Arg Leu Pro Asn Gly Ile Gln Gln Gly 
            180                 185                 190         


Ser Thr Phe Asn Leu Gly Asp Lys Val Arg Tyr Ser Cys Asn Leu Gly 
        195                 200                 205             


Phe Phe Leu Glu Gly His Ala Val Leu Thr Cys His Ala Gly Ser Glu 
    210                 215                 220                 


Asn Ser Ala Thr Trp Asp Phe Pro Leu Pro Ser Cys Arg Ala Asp Asp 
225                 230                 235                 240 


Ala Cys Gly Gly Thr Leu Arg Gly Gln Ser Gly Ile Ile Ser Ser Pro 
                245                 250                 255     


His Phe Pro Ser Glu Tyr His Asn Asn Ala Asp Cys Thr Trp Thr Ile 
            260                 265                 270         


Leu Ala Glu Leu Gly Asp Thr Ile Ala Leu Val Phe Ile Asp Phe Gln 
        275                 280                 285             


Leu Glu Asp Gly Tyr Asp Phe Leu Glu Val Thr Gly Thr Glu Gly Ser 
    290                 295                 300                 


Ser Leu Trp Phe Thr Gly Ala Ser Leu Pro Ala Pro Val Ile Ser Ser 
305                 310                 315                 320 


Lys Asn Trp Leu Arg Leu His Phe Thr Ser Asp Gly Asn His Arg Gln 
                325                 330                 335     


Arg Gly Phe Ser Ala Gln Tyr Gln Val Lys Lys Gln Ile Glu Leu Lys 
            340                 345                 350         


Ser Arg Gly Val Lys Leu Met Pro Ser Lys Asp Asn Ser Gln Lys Thr 
        355                 360                 365             


Ser Val Leu Thr Gln Val Gly Val Ser Gln Gly His Asn Met Cys Pro 
    370                 375                 380                 


Asp Pro Gly Ile Pro Glu Arg Gly Lys Arg Leu Gly Ser Asp Phe Arg 
385                 390                 395                 400 


Leu Gly Ser Ser Val Gln Phe Thr Cys Asn Glu Gly Tyr Asp Leu Gln 
                405                 410                 415     


Gly Ser Lys Arg Ile Thr Cys Met Lys Val Ser Asp Met Phe Ala Ala 
            420                 425                 430         


Trp Ser Asp His Arg Pro Val Cys Arg Ala Arg Met Cys Asp Ala His 
        435                 440                 445             


Leu Arg Gly Pro Ser Gly Ile Ile Thr Ser Pro Asn Phe Pro Ile Gln 
    450                 455                 460                 


Tyr Asp Asn Asn Ala His Cys Val Trp Ile Ile Thr Ala Leu Asn Pro 
465                 470                 475                 480 


Ser Lys Val Ile Lys Leu Ala Phe Glu Glu Phe Asp Leu Glu Arg Gly 
                485                 490                 495     


Tyr Asp Thr Leu Thr Val Gly Asp Gly Gly Gln Asp Gly Asp Gln Lys 
            500                 505                 510         


Thr Val Leu Tyr Ile Leu Thr Gly Thr Ser Val Pro Asp Leu Ile Val 
        515                 520                 525             


Ser Thr Asn His Gln Met Trp Leu Leu Phe Gln Thr Asp Gly Ser Gly 
    530                 535                 540                 


Ser Ser Leu Gly Phe Lys Ala Ser Tyr Glu Glu Ile Glu Gln Gly Ser 
545                 550                 555                 560 


Cys Gly Asp Pro Gly Ile Pro Ala Tyr Gly Arg Arg Glu Gly Ser Arg 
                565                 570                 575     


Phe His His Gly Asp Thr Leu Lys Phe Glu Cys Gln Pro Ala Phe Glu 
            580                 585                 590         


Leu Val Gly Gln Lys Ala Ile Thr Cys Gln Lys Asn Asn Gln Trp Ser 
        595                 600                 605             


Ala Lys Lys Pro Gly Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ser 
    610                 615                 620                 


Pro Ser Gly Val Val Leu Ser Pro Asn Tyr Pro Glu Asp Tyr Gly Asn 
625                 630                 635                 640 


His Leu His Cys Val Trp Leu Ile Leu Ala Arg Pro Glu Ser Arg Ile 
                645                 650                 655     


His Leu Ala Phe Asn Asp Ile Asp Val Glu Pro Gln Phe Asp Phe Leu 
            660                 665                 670         


Val Ile Lys Asp Gly Ala Thr Ala Glu Ala Pro Val Leu Gly Thr Phe 
        675                 680                 685             


Ser Gly Asn Gln Leu Pro Ser Ser Ile Thr Ser Ser Gly His Val Ala 
    690                 695                 700                 


Arg Leu Glu Phe Gln Thr Asp His Ser Thr Gly Lys Arg Gly Phe Asn 
705                 710                 715                 720 


Ile Thr Phe Thr Thr Phe Arg His Asn Glu Cys Pro Asp Pro Gly Val 
                725                 730                 735     


Pro Val Asn Gly Lys Arg Phe Gly Asp Ser Leu Gln Leu Gly Ser Ser 
            740                 745                 750         


Ile Ser Phe Leu Cys Asp Glu Gly Phe Leu Gly Thr Gln Gly Ser Glu 
        755                 760                 765             


Thr Ile Thr Cys Val Leu Lys Glu Gly Ser Val Val Trp Asn Ser Ala 
    770                 775                 780                 


Val Leu Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ser Pro Ser 
785                 790                 795                 800 


Gly Thr Ile Leu Ser Pro Gly Trp Pro Gly Phe Tyr Lys Asp Ala Leu 
                805                 810                 815     


Ser Cys Ala Trp Val Ile Glu Ala Gln Pro Gly Tyr Pro Ile Lys Ile 
            820                 825                 830         


Thr Phe Asp Arg Phe Lys Thr Glu Val Asn Tyr Asp Thr Leu Glu Val 
        835                 840                 845             


Arg Asp Gly Arg Thr Tyr Ser Ala Pro Leu Ile Gly Val Tyr His Gly 
    850                 855                 860                 


Thr Gln Val Pro Gln Phe Leu Ile Ser Thr Ser Asn Tyr Leu Tyr Leu 
865                 870                 875                 880 


Leu Phe Ser Thr Asp Lys Ser His Ser Asp Ile Gly Phe Gln Leu Arg 
                885                 890                 895     


Tyr Glu Thr Ile Thr Leu Gln Ser Asp His Cys Leu Asp Pro Gly Ile 
            900                 905                 910         


Pro Val Asn Gly Gln Arg His Gly Asn Asp Phe Tyr Val Gly Ala Leu 
        915                 920                 925             


Val Thr Phe Ser Cys Asp Ser Gly Tyr Thr Leu Ser Asp Gly Glu Pro 
    930                 935                 940                 


Leu Glu Cys Glu Pro Asn Phe Gln Trp Ser Arg Ala Leu Pro Ser Cys 
945                 950                 955                 960 


Glu Ala Leu Cys Gly Gly Phe Ile Gln Gly Ser Ser Gly Thr Ile Leu 
                965                 970                 975     


Ser Pro Gly Phe Pro Asp Phe Tyr Pro Asn Asn Leu Asn Cys Thr Trp 
            980                 985                 990         


Ile Ile Glu Thr Ser His Gly Lys  Gly Val Phe Phe Thr  Phe His Thr 
        995                 1000                 1005             


Phe His  Leu Glu Ser Gly His  Asp Tyr Leu Leu Ile  Thr Glu Asn 
    1010                 1015                 1020             


Gly Ser  Phe Thr Gln Pro Leu  Arg Gln Leu Thr Gly  Ser Arg Leu 
    1025                 1030                 1035             


Pro Ala  Pro Ile Ser Ala Gly  Leu Tyr Gly Asn Phe  Thr Ala Gln 
    1040                 1045                 1050             


Val Arg  Phe Ile Ser Asp Phe  Ser Met Ser Tyr Glu  Gly Phe Asn 
    1055                 1060                 1065             


Ile Thr  Phe Ser Glu Tyr Asp  Leu Glu Pro Cys Glu  Glu Pro Glu 
    1070                 1075                 1080             


Val Pro  Ala Tyr Ser Ile Arg  Lys Gly Leu Gln Phe  Gly Val Gly 
    1085                 1090                 1095             


Asp Thr  Leu Thr Phe Ser Cys  Phe Pro Gly Tyr Arg  Leu Glu Gly 
    1100                 1105                 1110             


Thr Ala  Arg Ile Thr Cys Leu  Gly Gly Arg Arg Arg  Leu Trp Ser 
    1115                 1120                 1125             


Ser Pro  Leu Pro Arg Cys Val  Ala Glu Cys Gly Asn  Ser Val Thr 
    1130                 1135                 1140             


Gly Thr  Gln Gly Thr Leu Leu  Ser Pro Asn Phe Pro  Val Asn Tyr 
    1145                 1150                 1155             


Asn Asn  Asn His Glu Cys Ile  Tyr Ser Ile Gln Thr  Gln Pro Gly 
    1160                 1165                 1170             


Lys Gly  Ile Gln Leu Lys Ala  Arg Ala Phe Glu Leu  Ser Glu Gly 
    1175                 1180                 1185             


Asp Val  Leu Lys Val Tyr Asp  Gly Asn Asn Asn Ser  Ala Arg Leu 
    1190                 1195                 1200             


Leu Gly  Val Phe Ser His Ser  Glu Met Met Gly Val  Thr Leu Asn 
    1205                 1210                 1215             


Ser Thr  Ser Ser Ser Leu Trp  Leu Asp Phe Ile Thr  Asp Ala Glu 
    1220                 1225                 1230             


Asn Thr  Ser Lys Gly Phe Glu  Leu His Phe Ser Ser  Phe Glu Leu 
    1235                 1240                 1245             


Ile Lys  Cys Glu Asp Pro Gly  Thr Pro Lys Phe Gly  Tyr Lys Val 
    1250                 1255                 1260             


His Asp  Glu Gly His Phe Ala  Gly Ser Ser Val Ser  Phe Ser Cys 
    1265                 1270                 1275             


Asp Pro  Gly Tyr Ser Leu Arg  Gly Ser Glu Glu Leu  Leu Cys Leu 
    1280                 1285                 1290             


Ser Gly  Glu Arg Arg Thr Trp  Asp Arg Pro Leu Pro  Thr Cys Val 
    1295                 1300                 1305             


Ala Glu  Cys Gly Gly Thr Val  Arg Gly Glu Val Ser  Gly Gln Val 
    1310                 1315                 1320             


Leu Ser  Pro Gly Tyr Pro Ala  Pro Tyr Glu His Asn  Leu Asn Cys 
    1325                 1330                 1335             


Ile Trp  Thr Ile Glu Ala Glu  Ala Gly Cys Thr Ile  Gly Leu His 
    1340                 1345                 1350             


Phe Leu  Val Phe Asp Thr Glu  Glu Val His Asp Val  Leu Arg Ile 
    1355                 1360                 1365             


Trp Asp  Gly Pro Val Glu Ser  Gly Val Leu Leu Lys  Glu Leu Ser 
    1370                 1375                 1380             


Gly Pro  Ala Leu Pro Lys Asp  Leu His Ser Thr Phe  Asn Ser Val 
    1385                 1390                 1395             


Val Leu  Gln Phe Ser Thr Asp  Phe Phe Thr Ser Lys  Gln Gly Phe 
    1400                 1405                 1410             


Ala Ile  Gln Phe Ser Val Ser  Thr Ala Thr Ser Cys  Asn Asp Pro 
    1415                 1420                 1425             


Gly Ile  Pro Gln Asn Gly Ser  Arg Ser Gly Asp Ser  Trp Glu Ala 
    1430                 1435                 1440             


Gly Asp  Ser Thr Val Phe Gln  Cys Asp Pro Gly Tyr  Ala Leu Gln 
    1445                 1450                 1455             


Gly Ser  Ala Glu Ile Ser Cys  Val Lys Ile Glu Asn  Arg Phe Phe 
    1460                 1465                 1470             


Trp Gln  Pro Ser Pro Pro Thr  Cys Ile Ala Pro Cys  Gly Gly Asp 
    1475                 1480                 1485             


Leu Thr  Gly Pro Ser Gly Val  Ile Leu Ser Pro Asn  Tyr Pro Glu 
    1490                 1495                 1500             


Pro Tyr  Pro Pro Gly Lys Glu  Cys Asp Trp Lys Val  Thr Val Ser 
    1505                 1510                 1515             


Pro Asp  Tyr Val Ile Ala Leu  Val Phe Asn Ile Phe  Asn Leu Glu 
    1520                 1525                 1530             


Pro Gly  Tyr Asp Phe Leu His  Ile Tyr Asp Gly Arg  Asp Ser Leu 
    1535                 1540                 1545             


Ser Pro  Leu Ile Gly Ser Phe  Tyr Gly Ser Gln Leu  Pro Gly Arg 
    1550                 1555                 1560             


Ile Glu  Ser Ser Ser Asn Ser  Leu Phe Leu Ala Phe  Arg Ser Asp 
    1565                 1570                 1575             


Ala Ser  Val Ser Asn Ala Gly  Phe Val Ile Asp Tyr  Thr Glu Asn 
    1580                 1585                 1590             


Pro Arg  Glu Ser Cys Phe Asp  Pro Gly Ser Ile Lys  Asn Gly Thr 
    1595                 1600                 1605             


Arg Val  Gly Ser Asp Leu Lys  Leu Gly Ser Ser Val  Thr Tyr Tyr 
    1610                 1615                 1620             


Cys His  Gly Gly Tyr Glu Val  Glu Gly Thr Ser Thr  Leu Ser Cys 
    1625                 1630                 1635             


Ile Leu  Gly Pro Asp Gly Lys  Pro Val Trp Asn Asn  Pro Arg Pro 
    1640                 1645                 1650             


Val Cys  Thr Ala Pro Cys Gly  Gly Gln Tyr Val Gly  Ser Asp Gly 
    1655                 1660                 1665             


Val Val  Leu Ser Pro Asn Tyr  Pro Gln Asn Tyr Thr  Ser Gly Gln 
    1670                 1675                 1680             


Ile Cys  Leu Tyr Phe Val Thr  Val Pro Lys Asp Tyr  Val Val Phe 
    1685                 1690                 1695             


Gly Gln  Phe Ala Phe Phe His  Thr Ala Leu Asn Asp  Val Val Glu 
    1700                 1705                 1710             


Val His  Asp Gly His Ser Gln  His Ser Arg Leu Leu  Ser Ser Leu 
    1715                 1720                 1725             


Ser Gly  Ser His Thr Gly Glu  Ser Leu Pro Leu Ala  Thr Ser Asn 
    1730                 1735                 1740             


Gln Val  Leu Ile Lys Phe Ser  Ala Lys Gly Leu Ala  Pro Ala Arg 
    1745                 1750                 1755             


Gly Phe  His Phe Val Tyr Gln  Ala Val Pro Arg Thr  Ser Ala Thr 
    1760                 1765                 1770             


Gln Cys  Ser Ser Val Pro Glu  Pro Arg Tyr Gly Lys  Arg Leu Gly 
    1775                 1780                 1785             


Ser Asp  Phe Ser Val Gly Ala  Ile Val Arg Phe Glu  Cys Asn Ser 
    1790                 1795                 1800             


Gly Tyr  Ala Leu Gln Gly Ser  Pro Glu Ile Glu Cys  Leu Pro Val 
    1805                 1810                 1815             


Pro Gly  Ala Leu Ala Gln Trp  Asn Val Ser Ala Pro  Thr Cys Val 
    1820                 1825                 1830             


Val Pro  Cys Gly Gly Asn Leu  Thr Glu Arg Arg Gly  Thr Ile Leu 
    1835                 1840                 1845             


Ser Pro  Gly Phe Pro Glu Pro  Tyr Leu Asn Ser Leu  Asn Cys Val 
    1850                 1855                 1860             


Trp Lys  Ile Val Val Pro Glu  Gly Ala Gly Ile Gln  Ile Gln Val 
    1865                 1870                 1875             


Val Ser  Phe Val Thr Glu Gln  Asn Trp Asp Ser Leu  Glu Val Phe 
    1880                 1885                 1890             


Asp Gly  Ala Asp Asn Thr Val  Thr Met Leu Gly Ser  Phe Ser Gly 
    1895                 1900                 1905             


Thr Thr  Val Pro Ala Leu Leu  Asn Ser Thr Ser Asn  Gln Leu Tyr 
    1910                 1915                 1920             


Leu His  Phe Tyr Ser Asp Ile  Ser Val Ser Ala Ala  Gly Phe His 
    1925                 1930                 1935             


Leu Glu  Tyr Lys Thr Val Gly  Leu Ser Ser Cys Pro  Glu Pro Ala 
    1940                 1945                 1950             


Val Pro  Ser Asn Gly Val Lys  Thr Gly Glu Arg Tyr  Leu Val Asn 
    1955                 1960                 1965             


Asp Val  Val Ser Phe Gln Cys  Glu Pro Gly Tyr Ala  Leu Gln Gly 
    1970                 1975                 1980             


His Ala  His Ile Ser Cys Met  Pro Gly Thr Val Arg  Arg Trp Asn 
    1985                 1990                 1995             


Tyr Pro  Pro Pro Leu Cys Ile  Ala Gln Cys Gly Gly  Thr Val Glu 
    2000                 2005                 2010             


Glu Met  Glu Gly Val Ile Leu  Ser Pro Gly Phe Pro  Gly Asn Tyr 
    2015                 2020                 2025             


Pro Ser  Asn Met Asp Cys Ser  Trp Lys Ile Ala Leu  Pro Val Gly 
    2030                 2035                 2040             


Phe Gly  Ala His Ile Gln Phe  Leu Asn Phe Ser Thr  Glu Pro Asn 
    2045                 2050                 2055             


His Asp  Tyr Ile Glu Ile Arg  Asn Gly Pro Tyr Glu  Thr Ser Arg 
    2060                 2065                 2070             


Met Met  Gly Arg Phe Ser Gly  Ser Glu Leu Pro Ser  Ser Leu Leu 
    2075                 2080                 2085             


Ser Thr  Ser His Glu Thr Thr  Val Tyr Phe His Ser  Asp His Ser 
    2090                 2095                 2100             


Gln Asn  Arg Pro Gly Phe Lys  Leu Glu Tyr Gln Ala  Tyr Glu Leu 
    2105                 2110                 2115             


Gln Glu  Cys Pro Asp Pro Glu  Pro Phe Ala Asn Gly  Ile Val Arg 
    2120                 2125                 2130             


Gly Ala  Gly Tyr Asn Val Gly  Gln Ser Val Thr Phe  Glu Cys Leu 
    2135                 2140                 2145             


Pro Gly  Tyr Gln Leu Thr Gly  His Pro Val Leu Thr  Cys Gln His 
    2150                 2155                 2160             


Gly Thr  Asn Arg Asn Trp Asp  His Pro Leu Pro Lys  Cys Glu Val 
    2165                 2170                 2175             


Pro Cys  Gly Gly Asn Ile Thr  Ser Ser Asn Gly Thr  Val Tyr Ser 
    2180                 2185                 2190             


Pro Gly  Phe Pro Ser Pro Tyr  Ser Ser Ser Gln Asp  Cys Val Trp 
    2195                 2200                 2205             


Leu Ile  Thr Val Pro Ile Gly  His Gly Val Arg Leu  Asn Leu Ser 
    2210                 2215                 2220             


Leu Leu  Gln Thr Glu Pro Ser  Gly Asp Phe Ile Thr  Ile Trp Asp 
    2225                 2230                 2235             


Gly Pro  Gln Gln Thr Ala Pro  Arg Leu Gly Val Phe  Thr Arg Ser 
    2240                 2245                 2250             


Met Ala  Lys Lys Thr Val Gln  Ser Ser Ser Asn Gln  Val Leu Leu 
    2255                 2260                 2265             


Lys Phe  His Arg Asp Ala Ala  Thr Gly Gly Ile Phe  Ala Ile Ala 
    2270                 2275                 2280             


Phe Ser  Ala Tyr Pro Leu Thr  Lys Cys Pro Pro Pro  Thr Ile Leu 
    2285                 2290                 2295             


Pro Asn  Ala Glu Val Val Thr  Glu Asn Glu Glu Phe  Asn Ile Gly 
    2300                 2305                 2310             


Asp Ile  Val Arg Tyr Arg Cys  Leu Pro Gly Phe Thr  Leu Val Gly 
    2315                 2320                 2325             


Asn Glu  Ile Leu Thr Cys Lys  Leu Gly Thr Tyr Leu  Gln Phe Glu 
    2330                 2335                 2340             


Gly Pro  Pro Pro Ile Cys Glu  Val His Cys Pro Thr  Asn Glu Leu 
    2345                 2350                 2355             


Leu Thr  Asp Ser Thr Gly Val  Ile Leu Ser Gln Ser  Tyr Pro Gly 
    2360                 2365                 2370             


Ser Tyr  Pro Gln Phe Gln Thr  Cys Ser Trp Leu Val  Arg Val Glu 
    2375                 2380                 2385             


Pro Asp  Tyr Asn Ile Ser Leu  Thr Val Glu Tyr Phe  Leu Ser Glu 
    2390                 2395                 2400             


Lys Gln  Tyr Asp Glu Phe Glu  Ile Phe Asp Gly Pro  Ser Gly Gln 
    2405                 2410                 2415             


Ser Pro  Leu Leu Lys Ala Leu  Ser Gly Asn Tyr Ser  Ala Pro Leu 
    2420                 2425                 2430             


Ile Val  Thr Ser Ser Ser Asn  Ser Val Tyr Leu Arg  Trp Ser Ser 
    2435                 2440                 2445             


Asp His  Ala Tyr Asn Arg Lys  Gly Phe Lys Ile Arg  Tyr Ser Ala 
    2450                 2455                 2460             


Pro Tyr  Cys Ser Leu Pro Arg  Ala Pro Leu His Gly  Phe Ile Leu 
    2465                 2470                 2475             


Gly Gln  Thr Ser Thr Gln Pro  Gly Gly Ser Ile His  Phe Gly Cys 
    2480                 2485                 2490             


Asn Ala  Gly Tyr Arg Leu Val  Gly His Ser Met Ala  Ile Cys Thr 
    2495                 2500                 2505             


Arg His  Pro Gln Gly Tyr His  Leu Trp Ser Glu Ala  Ile Pro Leu 
    2510                 2515                 2520             


Cys Gln  Ala Leu Ser Cys Gly  Leu Pro Glu Ala Pro  Lys Asn Gly 
    2525                 2530                 2535             


Met Val  Phe Gly Lys Glu Tyr  Thr Val Gly Thr Lys  Ala Met Tyr 
    2540                 2545                 2550             


Ser Cys  Ser Glu Gly Tyr His  Leu Gln Ala Gly Ala  Glu Ala Thr 
    2555                 2560                 2565             


Ala Glu  Cys Leu Asp Thr Gly  Leu Trp Ser Asn Arg  Asn Val Pro 
    2570                 2575                 2580             


Pro Gln  Cys Val Pro Val Thr  Cys Pro Asp Val Ser  Ser Ile Ser 
    2585                 2590                 2595             


Val Glu  His Gly Arg Trp Arg  Leu Ile Phe Glu Thr  Gln Tyr Gln 
    2600                 2605                 2610             


Phe Gln  Ala Gln Leu Met Leu  Ile Cys Asp Pro Gly  Tyr Tyr Tyr 
    2615                 2620                 2625             


Thr Gly  Gln Arg Val Ile Arg  Cys Gln Ala Asn Gly  Lys Trp Ser 
    2630                 2635                 2640             


Leu Gly  Asp Ser Thr Pro Thr  Cys Arg Ile Ile Ser  Cys Gly Glu 
    2645                 2650                 2655             


Leu Pro  Ile Pro Pro Asn Gly  His Arg Ile Gly Thr  Leu Ser Val 
    2660                 2665                 2670             


Tyr Gly  Ala Thr Ala Ile Phe  Ser Cys Asn Ser Gly  Tyr Thr Leu 
    2675                 2680                 2685             


Val Gly  Ser Arg Val Arg Glu  Cys Met Ala Asn Gly  Leu Trp Ser 
    2690                 2695                 2700             


Gly Ser  Glu Val Arg Cys Leu  Ala Gly His Cys Gly  Thr Pro Glu 
    2705                 2710                 2715             


Pro Ile  Val Asn Gly His Ile  Asn Gly Glu Asn Tyr  Ser Tyr Arg 
    2720                 2725                 2730             


Gly Ser  Val Val Tyr Gln Cys  Asn Ala Gly Phe Arg  Leu Ile Gly 
    2735                 2740                 2745             


Met Ser  Val Arg Ile Cys Gln  Gln Asp His His Trp  Ser Gly Lys 
    2750                 2755                 2760             


Thr Pro  Phe Cys Val Pro Ile  Thr Cys Gly His Pro  Gly Asn Pro 
    2765                 2770                 2775             


Val Asn  Gly Leu Thr Gln Gly  Asn Gln Phe Asn Leu  Asn Asp Val 
    2780                 2785                 2790             


Val Lys  Phe Val Cys Asn Pro  Gly Tyr Met Ala Glu  Gly Ala Ala 
    2795                 2800                 2805             


Arg Ser  Gln Cys Leu Ala Ser  Gly Gln Trp Ser Asp  Met Leu Pro 
    2810                 2815                 2820             


Thr Cys  Arg Ile Ile Asn Cys  Thr Asp Pro Gly His  Gln Glu Asn 
    2825                 2830                 2835             


Ser Val  Arg Gln Val His Ala  Ser Gly Pro His Arg  Phe Ser Phe 
    2840                 2845                 2850             


Gly Thr  Thr Val Ser Tyr Arg  Cys Asn His Gly Phe  Tyr Leu Leu 
    2855                 2860                 2865             


Gly Thr  Pro Val Leu Ser Cys  Gln Gly Asp Gly Thr  Trp Asp Arg 
    2870                 2875                 2880             


Pro Arg  Pro Gln Cys Leu Leu  Val Ser Cys Gly His  Pro Gly Ser 
    2885                 2890                 2895             


Pro Pro  His Ser Gln Met Ser  Gly Asp Ser Tyr Thr  Val Gly Ala 
    2900                 2905                 2910             


Val Val  Arg Tyr Ser Cys Ile  Gly Lys Arg Thr Leu  Val Gly Asn 
    2915                 2920                 2925             


Ser Thr  Arg Met Cys Gly Leu  Asp Gly His Trp Thr  Gly Ser Leu 
    2930                 2935                 2940             


Pro His  Cys Ser Gly Thr Ser  Val Gly Val Cys Gly  Asp Pro Gly 
    2945                 2950                 2955             


Ile Pro  Ala His Gly Ile Arg  Leu Gly Asp Ser Phe  Asp Pro Gly 
    2960                 2965                 2970             


Thr Val  Met Arg Phe Ser Cys  Glu Ala Gly His Val  Leu Arg Gly 
    2975                 2980                 2985             


Ser Ser  Glu Arg Thr Cys Gln  Ala Asn Gly Ser Trp  Ser Gly Ser 
    2990                 2995                 3000             


Gln Pro  Glu Cys Gly Val Ile  Ser Cys Gly Asn Pro  Gly Thr Pro 
    3005                 3010                 3015             


Ser Asn  Ala Arg Val Val Phe  Ser Asp Gly Leu Val  Phe Ser Ser 
    3020                 3025                 3030             


Ser Ile  Val Tyr Glu Cys Arg  Glu Gly Tyr Tyr Ala  Thr Gly Leu 
    3035                 3040                 3045             


Leu Ser  Arg His Cys Ser Val  Asn Gly Thr Trp Thr  Gly Ser Asp 
    3050                 3055                 3060             


Pro Glu  Cys Leu Val Ile Asn  Cys Gly Asp Pro Gly  Ile Pro Ala 
    3065                 3070                 3075             


Asn Gly  Leu Arg Leu Gly Asn  Asp Phe Arg Tyr Asn  Lys Thr Val 
    3080                 3085                 3090             


Thr Tyr  Gln Cys Val Pro Gly  Tyr Met Met Glu Ser  His Arg Val 
    3095                 3100                 3105             


Ser Val  Leu Ser Cys Thr Lys  Asp Arg Thr Trp Asn  Gly Thr Lys 
    3110                 3115                 3120             


Pro Val  Cys Lys Ala Leu Met  Cys Lys Pro Pro Pro  Leu Ile Pro 
    3125                 3130                 3135             


Asn Gly  Lys Val Val Gly Ser  Asp Phe Met Trp Gly  Ser Ser Val 
    3140                 3145                 3150             


Thr Tyr  Ala Cys Leu Glu Gly  Tyr Gln Leu Ser Leu  Pro Ala Val 
    3155                 3160                 3165             


Phe Thr  Cys Glu Gly Asn Gly  Ser Trp Thr Gly Glu  Leu Pro Gln 
    3170                 3175                 3180             


Cys Phe  Pro Val Phe Cys Gly  Asp Pro Gly Val Pro  Ser Arg Gly 
    3185                 3190                 3195             


Arg Arg  Glu Asp Arg Gly Phe  Ser Tyr Arg Ser Ser  Val Ser Phe 
    3200                 3205                 3210             


Ser Cys  His Pro Pro Leu Val  Leu Val Gly Ser Pro  Arg Arg Phe 
    3215                 3220                 3225             


Cys Gln  Ser Asp Gly Thr Trp  Ser Gly Thr Gln Pro  Ser Cys Ile 
    3230                 3235                 3240             


Asp Pro  Thr Leu Thr Thr Cys  Ala Asp Pro Gly Val  Pro Gln Phe 
    3245                 3250                 3255             


Gly Ile  Gln Asn Asn Ser Gln  Gly Tyr Gln Val Gly  Ser Thr Val 
    3260                 3265                 3270             


Leu Phe  Arg Cys Gln Lys Gly  Tyr Leu Leu Gln Gly  Ser Thr Thr 
    3275                 3280                 3285             


Arg Thr  Cys Leu Pro Asn Leu  Thr Trp Ser Gly Thr  Pro Pro Asp 
    3290                 3295                 3300             


Cys Val  Pro His His Cys Arg  Gln Pro Glu Thr Pro  Thr His Ala 
    3305                 3310                 3315             


Asn Val  Gly Ala Leu Asp Leu  Pro Ser Met Gly Tyr  Thr Leu Ile 
    3320                 3325                 3330             


Tyr Ser  Cys Gln Glu Gly Phe  Ser Leu Lys Gly Gly  Ser Glu His 
    3335                 3340                 3345             


Arg Thr  Cys Lys Ala Asp Gly  Ser Trp Thr Gly Lys  Pro Pro Ile 
    3350                 3355                 3360             


Cys Leu  Ala Glu Val Arg Pro  Ser Gly Arg Pro Ile  Asn Thr Ala 
    3365                 3370                 3375             


Arg Glu  Pro Pro Leu Thr Gln  Ala Leu Ile Pro Gly  Asp Val Phe 
    3380                 3385                 3390             


Ala Lys  Asn Ser Leu Trp Lys  Gly Ala Tyr Glu Tyr  Gln Gly Lys 
    3395                 3400                 3405             


Lys Gln  Pro Ala Met Leu Arg  Val Thr Gly Phe Gln  Val Ala Asn 
    3410                 3415                 3420             


Ser Lys  Val Asn Ala Thr Met  Ile Asp His Ser Gly  Val Glu Leu 
    3425                 3430                 3435             


His Leu  Ala Gly Thr Tyr Lys  Lys Glu Asp Phe His  Leu Leu Leu 
    3440                 3445                 3450             


Gln Val  Tyr Gln Ile Thr Gly  Pro Val Glu Ile Phe  Met Asn Lys 
    3455                 3460                 3465             


Phe Lys  Asp Asp His Trp Ala  Leu Asp Gly His Val  Ser Ser Glu 
    3470                 3475                 3480             


Ser Ser  Gly Ala Thr Phe Ile  Tyr Gln Gly Ser Val  Lys Gly Gln 
    3485                 3490                 3495             


Gly Phe  Gly Gln Phe Gly Phe  Gln Arg Leu Asp Leu  Arg Leu Leu 
    3500                 3505                 3510             


Glu Ser  Asp Pro Glu Ser Ile  Gly Arg His Phe Ala  Ser Asn Ser 
    3515                 3520                 3525             


Ser Ser  Val Ala Ala Ala Ile  Leu Val Pro Phe Ile  Ala Leu Ile 
    3530                 3535                 3540             


Ile Ala  Gly Phe Val Leu Tyr  Leu Tyr Lys His Arg  Arg Arg Pro 
    3545                 3550                 3555             


Lys Val  Pro Phe Asn Gly Tyr  Ala Gly His Glu Asn  Thr Asn Val 
    3560                 3565                 3570             


Arg Ala  Thr Phe Glu Asn Pro  Met Tyr Asp Arg Asn  Ile Gln Pro 
    3575                 3580                 3585             


Thr Asp  Ile Met Ala Ser Glu  Ala Glu Phe Thr Val  Ser Thr Val 
    3590                 3595                 3600             


Cys Thr  Ala Val 
    3605         


<210>  2644
<211>  3538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSMD3__Homo_sapiens__NP_443132

<400>  2644

Met Lys Gly Ile Arg Lys Gly Glu Ser Arg Ala Lys Glu Ser Lys Pro 
1               5                   10                  15      


Trp Glu Pro Gly Lys Arg Arg Cys Ala Lys Cys Gly Arg Leu Asp Phe 
            20                  25                  30          


Ile Leu Met Lys Lys Met Gly Ile Lys Ser Gly Phe Thr Phe Trp Asn 
        35                  40                  45              


Leu Val Phe Leu Leu Thr Val Ser Cys Val Lys Gly Phe Ile Tyr Thr 
    50                  55                  60                  


Cys Gly Gly Thr Leu Lys Gly Leu Asn Gly Thr Ile Glu Ser Pro Gly 
65                  70                  75                  80  


Phe Pro Tyr Gly Tyr Pro Asn Gly Ala Asn Cys Thr Trp Val Ile Ile 
                85                  90                  95      


Ala Glu Glu Arg Asn Arg Ile Gln Ile Val Phe Gln Ser Phe Ala Leu 
            100                 105                 110         


Glu Glu Glu Tyr Asp Tyr Leu Ser Leu Tyr Asp Gly His Pro His Pro 
        115                 120                 125             


Thr Asn Phe Arg Thr Arg Leu Thr Gly Phe His Leu Pro Pro Pro Val 
    130                 135                 140                 


Thr Ser Thr Lys Ser Val Phe Ser Leu Arg Leu Thr Ser Asp Phe Ala 
145                 150                 155                 160 


Val Ser Ala His Gly Phe Lys Val Tyr Tyr Glu Glu Leu Gln Ser Ser 
                165                 170                 175     


Ser Cys Gly Asn Pro Gly Val Pro Pro Lys Gly Val Leu Tyr Gly Thr 
            180                 185                 190         


Arg Phe Asp Val Gly Asp Lys Ile Arg Tyr Ser Cys Val Thr Gly Tyr 
        195                 200                 205             


Ile Leu Asp Gly His Pro Gln Leu Thr Cys Ile Ala Asn Ser Val Asn 
    210                 215                 220                 


Thr Ala Ser Trp Asp Phe Pro Val Pro Ile Cys Arg Ala Glu Asp Ala 
225                 230                 235                 240 


Cys Gly Gly Thr Met Arg Gly Ser Ser Gly Ile Ile Ser Ser Pro Ser 
                245                 250                 255     


Phe Pro Asn Glu Tyr His Asn Asn Ala Asp Cys Thr Trp Thr Ile Val 
            260                 265                 270         


Ala Glu Pro Gly Asp Thr Ile Ser Leu Ile Phe Thr Asp Phe Gln Met 
        275                 280                 285             


Glu Glu Lys Tyr Asp Tyr Leu Glu Ile Glu Gly Ser Glu Pro Pro Thr 
    290                 295                 300                 


Ile Trp Leu Ser Gly Met Asn Ile Pro Pro Pro Ile Ile Ser Asn Lys 
305                 310                 315                 320 


Asn Trp Leu Arg Leu His Phe Val Thr Asp Ser Asn His Arg Tyr Arg 
                325                 330                 335     


Gly Phe Ser Ala Pro Tyr Gln Val Lys Lys Ala Ile Asp Phe Lys Ser 
            340                 345                 350         


Arg Gly Phe Lys Leu Phe Pro Gly Lys Asp Asn Ser Asn Lys Phe Ser 
        355                 360                 365             


Ile Leu Asn Glu Gly Gly Ile Lys Thr Ala Ser Asn Leu Cys Pro Asp 
    370                 375                 380                 


Pro Gly Glu Pro Glu Asn Gly Lys Arg Ile Gly Ser Asp Phe Ser Leu 
385                 390                 395                 400 


Gly Ser Thr Val Gln Phe Ser Cys Asp Glu Asp Tyr Val Leu Gln Gly 
                405                 410                 415     


Ala Lys Ser Ile Thr Cys Gln Arg Ile Ala Glu Val Phe Ala Ala Trp 
            420                 425                 430         


Ser Asp His Arg Pro Val Cys Lys Val Lys Thr Cys Gly Ser Asn Leu 
        435                 440                 445             


Gln Gly Pro Ser Gly Thr Phe Thr Ser Pro Asn Phe Pro Phe Gln Tyr 
    450                 455                 460                 


Asp Ser Asn Ala Gln Cys Val Trp Val Ile Thr Ala Val Asn Thr Asn 
465                 470                 475                 480 


Lys Val Ile Gln Ile Asn Phe Glu Glu Phe Asp Leu Glu Ile Gly Tyr 
                485                 490                 495     


Asp Thr Leu Thr Ile Gly Asp Gly Gly Glu Val Gly Asp Pro Arg Thr 
            500                 505                 510         


Val Leu Gln Val Leu Thr Gly Ser Phe Val Pro Asp Leu Ile Val Ser 
        515                 520                 525             


Met Ser Ser Gln Met Trp Leu His Leu Gln Thr Asp Glu Ser Val Gly 
    530                 535                 540                 


Ser Val Gly Phe Lys Val Asn Tyr Lys Glu Ile Glu Lys Glu Ser Cys 
545                 550                 555                 560 


Gly Asp Pro Gly Thr Pro Leu Tyr Gly Ile Arg Glu Gly Asp Gly Phe 
                565                 570                 575     


Ser Asn Arg Asp Val Leu Arg Phe Glu Cys Gln Phe Gly Phe Glu Leu 
            580                 585                 590         


Ile Gly Glu Lys Ser Ile Val Cys Gln Glu Asn Asn Gln Trp Ser Ala 
        595                 600                 605             


Asn Ile Pro Ile Cys Ile Phe Pro Cys Leu Ser Asn Phe Thr Ala Pro 
    610                 615                 620                 


Met Gly Thr Val Leu Ser Pro Asp Tyr Pro Glu Gly Tyr Gly Asn Asn 
625                 630                 635                 640 


Leu Asn Cys Ile Trp Thr Ile Ile Ser Asp Pro Gly Ser Arg Ile His 
                645                 650                 655     


Leu Ser Phe Asn Asp Phe Asp Leu Glu Ser Gln Phe Asp Phe Leu Ala 
            660                 665                 670         


Val Lys Asp Gly Asp Ser Pro Glu Ser Pro Ile Leu Gly Thr Phe Thr 
        675                 680                 685             


Gly Ala Glu Val Pro Ser His Leu Thr Ser Asn Ser His Ile Leu Arg 
    690                 695                 700                 


Leu Glu Phe Gln Ala Asp His Ser Met Ser Gly Arg Gly Phe Asn Ile 
705                 710                 715                 720 


Thr Tyr Asn Thr Phe Gly His Asn Glu Cys Pro Asp Pro Gly Ile Pro 
                725                 730                 735     


Ile Asn Ala Arg Arg Phe Gly Asp Asn Phe Gln Leu Gly Ser Ser Ile 
            740                 745                 750         


Ser Val Ile Cys Glu Glu Gly Phe Ile Lys Thr Gln Gly Thr Glu Thr 
        755                 760                 765             


Ile Thr Cys Ile Leu Met Asp Gly Lys Val Met Trp Ser Gly Leu Ile 
    770                 775                 780                 


Pro Lys Cys Gly Ala Pro Cys Gly Gly His Phe Ser Ala Pro Ser Gly 
785                 790                 795                 800 


Val Ile Leu Ser Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu Asn 
                805                 810                 815     


Cys Glu Trp Val Ile Glu Ala Glu Pro Gly His Ser Ile Lys Ile Thr 
            820                 825                 830         


Phe Glu Arg Phe Gln Thr Glu Leu Asn Tyr Asp Val Leu Glu Val His 
        835                 840                 845             


Asp Gly Pro Asn Leu Leu Ser Pro Leu Leu Gly Ser Tyr Asn Gly Thr 
    850                 855                 860                 


Gln Val Pro Gln Phe Leu Phe Ser Ser Ser Asn Phe Ile Tyr Leu Leu 
865                 870                 875                 880 


Phe Thr Thr Asp Asn Ser Arg Ser Asn Asn Gly Phe Lys Ile His Tyr 
                885                 890                 895     


Glu Ser Val Thr Val Asn Thr Tyr Ser Cys Leu Asp Pro Gly Ile Pro 
            900                 905                 910         


Val His Gly Arg Arg Tyr Gly His Asp Phe Ser Ile Gly Ser Thr Val 
        915                 920                 925             


Ser Phe Ser Cys Asp Ser Gly Tyr Arg Leu Ser His Glu Glu Pro Leu 
    930                 935                 940                 


Leu Cys Glu Lys Asn His Trp Trp Ser His Pro Leu Pro Thr Cys Asp 
945                 950                 955                 960 


Ala Leu Cys Gly Gly Asp Val Arg Gly Pro Ser Gly Thr Ile Leu Ser 
                965                 970                 975     


Pro Gly Tyr Pro Glu Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr 
            980                 985                 990         


Val Asp Val Thr His Gly Lys Gly  Val Gln Phe Asn Phe  His Thr Phe 
        995                 1000                 1005             


His Leu  Glu Asp His His Asp  Tyr Leu Leu Ile Thr  Glu Asn Gly 
    1010                 1015                 1020             


Ser Phe  Thr Gln Pro Leu Ala  Arg Leu Thr Gly Ser  Asp Leu Pro 
    1025                 1030                 1035             


Pro Thr  Ile Asn Ala Gly Leu  Tyr Gly Asn Phe Arg  Ala Gln Leu 
    1040                 1045                 1050             


Arg Phe  Ile Ser Asp Phe Ser  Ile Ser Tyr Glu Gly  Phe Asn Ile 
    1055                 1060                 1065             


Thr Phe  Ser Glu Tyr Asn Leu  Glu Pro Cys Glu Asp  Pro Gly Ile 
    1070                 1075                 1080             


Pro Gln  Tyr Gly Ser Arg Ile  Gly Phe Asn Phe Gly  Ile Gly Asp 
    1085                 1090                 1095             


Thr Leu  Thr Phe Ser Cys Ser  Ser Gly Tyr Arg Leu  Glu Gly Thr 
    1100                 1105                 1110             


Ser Glu  Ile Ile Cys Leu Gly  Gly Gly Arg Arg Val  Trp Ser Ala 
    1115                 1120                 1125             


Pro Leu  Pro Arg Cys Val Ala  Glu Cys Gly Ala Ser  Ala Thr Asn 
    1130                 1135                 1140             


Asn Glu  Gly Ile Leu Leu Ser  Pro Asn Tyr Pro Leu  Asn Tyr Glu 
    1145                 1150                 1155             


Asn Asn  His Glu Cys Ile Tyr  Ser Ile Gln Val Gln  Ala Gly Lys 
    1160                 1165                 1170             


Gly Ile  Asn Ile Ser Ala Arg  Thr Phe His Leu Ala  Gln Gly Asp 
    1175                 1180                 1185             


Val Leu  Lys Ile Tyr Asp Gly  Lys Asp Lys Thr Thr  His Leu Leu 
    1190                 1195                 1200             


Gly Ala  Phe Thr Gly Ala Ser  Met Arg Gly Leu Thr  Leu Ser Ser 
    1205                 1210                 1215             


Thr Ser  Asn Gln Leu Trp Leu  Glu Phe Asn Ser Asp  Thr Glu Gly 
    1220                 1225                 1230             


Thr Asp  Glu Gly Phe Gln Leu  Val Tyr Thr Ser Phe  Glu Leu Ser 
    1235                 1240                 1245             


His Cys  Glu Asp Pro Gly Ile  Pro Gln Phe Gly Tyr  Lys Ile Ser 
    1250                 1255                 1260             


Asp Gln  Gly His Phe Ala Gly  Ser Thr Ile Ile Tyr  Gly Cys Asn 
    1265                 1270                 1275             


Pro Gly  Tyr Thr Leu His Gly  Ser Ser Leu Leu Lys  Cys Met Thr 
    1280                 1285                 1290             


Gly Glu  Arg Arg Ala Trp Asp  Tyr Pro Leu Pro Ser  Cys Ile Ala 
    1295                 1300                 1305             


Glu Cys  Gly Gly Arg Phe Lys  Gly Glu Ser Ser Gly  Arg Ile Leu 
    1310                 1315                 1320             


Ser Pro  Gly Tyr Pro Phe Pro  Tyr Asp Asn Asn Leu  Arg Cys Met 
    1325                 1330                 1335             


Trp Met  Ile Glu Val Asp Pro  Gly Asn Ile Val Ser  Leu Gln Phe 
    1340                 1345                 1350             


Leu Ala  Phe Asp Thr Glu Ala  Ser His Asp Ile Leu  Arg Val Trp 
    1355                 1360                 1365             


Asp Gly  Pro Pro Glu Asn Asp  Met Leu Leu Lys Glu  Ile Ser Gly 
    1370                 1375                 1380             


Ser Leu  Ile Pro Glu Gly Ile  His Ser Thr Leu Asn  Ile Val Thr 
    1385                 1390                 1395             


Ile Gln  Phe Asp Thr Asp Phe  Tyr Ile Ser Lys Ser  Gly Phe Ala 
    1400                 1405                 1410             


Ile Gln  Phe Ser Ser Ser Val  Ala Thr Ala Cys Arg  Asp Pro Gly 
    1415                 1420                 1425             


Val Pro  Met Asn Gly Thr Arg  Asn Gly Asp Gly Arg  Glu Pro Gly 
    1430                 1435                 1440             


Asp Thr  Val Val Phe Gln Cys  Asp Pro Gly Tyr Glu  Leu Gln Gly 
    1445                 1450                 1455             


Glu Glu  Arg Ile Thr Cys Ile  Gln Val Glu Asn Arg  Tyr Phe Trp 
    1460                 1465                 1470             


Gln Pro  Ser Pro Pro Val Cys  Ile Ala Pro Cys Gly  Gly Asn Leu 
    1475                 1480                 1485             


Thr Gly  Ser Ser Gly Phe Ile  Leu Ser Pro Asn Phe  Pro His Pro 
    1490                 1495                 1500             


Tyr Pro  His Ser Arg Asp Cys  Asp Trp Thr Ile Thr  Val Asn Ala 
    1505                 1510                 1515             


Asp Tyr  Val Ile Ser Leu Ala  Phe Ile Ser Phe Ser  Ile Glu Pro 
    1520                 1525                 1530             


Asn Tyr  Asp Phe Leu Tyr Ile  Tyr Asp Gly Pro Asp  Ser Asn Ser 
    1535                 1540                 1545             


Pro Leu  Ile Gly Ser Phe Gln  Asp Ser Lys Leu Pro  Glu Arg Ile 
    1550                 1555                 1560             


Glu Ser  Ser Ser Asn Thr Met  His Leu Ala Phe Arg  Ser Asp Gly 
    1565                 1570                 1575             


Ser Val  Ser Tyr Thr Gly Phe  His Leu Glu Tyr Lys  Ala Lys Leu 
    1580                 1585                 1590             


Arg Glu  Ser Cys Phe Asp Pro  Gly Asn Ile Met Asn  Gly Thr Arg 
    1595                 1600                 1605             


Leu Gly  Met Asp Tyr Lys Leu  Gly Ser Thr Val Thr  Tyr Tyr Cys 
    1610                 1615                 1620             


Asp Ala  Gly Tyr Val Leu Gln  Gly Tyr Ser Thr Leu  Thr Cys Ile 
    1625                 1630                 1635             


Met Gly  Asp Asp Gly Arg Pro  Gly Trp Asn Arg Ala  Leu Pro Ser 
    1640                 1645                 1650             


Cys His  Ala Pro Cys Gly Ser  Arg Ser Thr Gly Ser  Glu Gly Thr 
    1655                 1660                 1665             


Val Leu  Ser Pro Asn Tyr Pro  Lys Asn Tyr Ser Val  Gly His Asn 
    1670                 1675                 1680             


Cys Val  Tyr Ser Ile Ala Val  Pro Lys Glu Phe Val  Val Phe Gly 
    1685                 1690                 1695             


Gln Phe  Val Phe Phe Gln Thr  Ser Leu His Asp Val  Val Glu Val 
    1700                 1705                 1710             


Tyr Asp  Gly Pro Thr Gln Gln  Ser Ser Leu Leu Ser  Ser Leu Ser 
    1715                 1720                 1725             


Gly Ser  His Ser Gly Glu Ser  Leu Pro Leu Ser Ser  Gly Asn Gln 
    1730                 1735                 1740             


Ile Thr  Ile Arg Phe Thr Ser  Val Gly Pro Ile Thr  Ala Lys Gly 
    1745                 1750                 1755             


Phe His  Phe Val Tyr Gln Ala  Val Pro Arg Thr Ser  Ser Thr Gln 
    1760                 1765                 1770             


Cys Ser  Ser Val Pro Glu Pro  Arg Phe Gly Arg Arg  Ile Gly Asn 
    1775                 1780                 1785             


Glu Phe  Ala Val Gly Ser Ser  Val Leu Phe Asp Cys  Asn Pro Gly 
    1790                 1795                 1800             


Tyr Ile  Leu His Gly Ser Ile  Ala Ile Arg Cys Glu  Thr Val Pro 
    1805                 1810                 1815             


Asn Ser  Leu Ala Gln Trp Asn  Asp Ser Leu Pro Thr  Cys Ile Val 
    1820                 1825                 1830             


Pro Cys  Gly Gly Ile Leu Thr  Lys Arg Lys Gly Thr  Ile Leu Ser 
    1835                 1840                 1845             


Pro Gly  Tyr Pro Glu Pro Tyr  Asp Asn Asn Leu Asn  Cys Val Trp 
    1850                 1855                 1860             


Lys Ile  Thr Val Pro Glu Gly  Ala Gly Ile Gln Val  Gln Val Val 
    1865                 1870                 1875             


Ser Phe  Ala Thr Glu His Asn  Trp Asp Ser Leu Asp  Phe Tyr Asp 
    1880                 1885                 1890             


Gly Gly  Asp Asn Asn Ala Pro  Arg Leu Gly Ser Tyr  Ser Gly Thr 
    1895                 1900                 1905             


Thr Ile  Pro His Leu Leu Asn  Ser Thr Ser Asn Asn  Leu Tyr Leu 
    1910                 1915                 1920             


Asn Phe  Gln Ser Asp Ile Ser  Val Ser Ala Ala Gly  Phe His Leu 
    1925                 1930                 1935             


Glu Tyr  Thr Ala Ile Gly Leu  Asp Ser Cys Pro Glu  Pro Gln Thr 
    1940                 1945                 1950             


Pro Ser  Ser Gly Ile Lys Ile  Gly Asp Arg Tyr Met  Val Gly Asp 
    1955                 1960                 1965             


Val Val  Ser Phe Gln Cys Asp  Gln Gly Tyr Ser Leu  Gln Gly His 
    1970                 1975                 1980             


Ser His  Ile Thr Cys Met Pro  Gly Pro Val Arg Arg  Trp Asn Tyr 
    1985                 1990                 1995             


Pro Ile  Pro Ile Cys Leu Ala  Gln Cys Gly Gly Ala  Met Ser Asp 
    2000                 2005                 2010             


Phe Ser  Gly Val Ile Leu Ser  Pro Gly Phe Pro Gly  Asn Tyr Pro 
    2015                 2020                 2025             


Ser Ser  Leu Asp Cys Thr Trp  Thr Ile Asn Leu Pro  Ile Gly Phe 
    2030                 2035                 2040             


Gly Val  His Leu Gln Phe Val  Asn Phe Ser Thr Glu  Thr Ile His 
    2045                 2050                 2055             


Asp Tyr  Leu Glu Val Arg Ser  Gly Ser Ser Glu Thr  Ser Thr Val 
    2060                 2065                 2070             


Ile Gly  Arg Leu Ser Gly Pro  Gln Ile Pro Ser Ser  Leu Phe Ser 
    2075                 2080                 2085             


Thr Thr  His Glu Thr Ser Leu  Tyr Phe His Ser Asp  Tyr Ser Gln 
    2090                 2095                 2100             


Asn Lys  Gln Gly Phe His Ile  Val Tyr Gln Ala Tyr  Gln Leu Gln 
    2105                 2110                 2115             


Ser Cys  Pro Asp Pro Arg Pro  Phe Arg Asn Gly Phe  Val Ile Gly 
    2120                 2125                 2130             


Asn Asp  Phe Thr Val Gly Gln  Thr Ile Ser Phe Glu  Cys Phe Pro 
    2135                 2140                 2145             


Gly Tyr  Thr Leu Ile Gly Asn  Ser Ala Leu Thr Cys  Leu His Gly 
    2150                 2155                 2160             


Val Ser  Arg Asn Trp Asn His  Pro Leu Pro Arg Cys  Glu Ala Leu 
    2165                 2170                 2175             


Cys Gly  Gly Asn Ile Thr Ala  Met Asn Gly Thr Ile  Tyr Ser Pro 
    2180                 2185                 2190             


Gly Tyr  Pro Asp Glu Tyr Pro  Asn Phe Gln Asp Cys  Phe Trp Leu 
    2195                 2200                 2205             


Val Arg  Val Pro Pro Gly Asn  Gly Ile Tyr Ile Asn  Phe Thr Val 
    2210                 2215                 2220             


Leu Gln  Thr Glu Pro Ile Tyr  Asp Phe Ile Thr Val  Trp Asp Gly 
    2225                 2230                 2235             


Pro Asp  Gln Asn Ser Pro Gln  Ile Gly Gln Phe Ser  Gly Asn Thr 
    2240                 2245                 2250             


Ala Leu  Glu Ser Val Tyr Ser  Thr Ser Asn Gln Ile  Leu Ile Lys 
    2255                 2260                 2265             


Phe His  Ser Asp Phe Thr Thr  Ser Gly Phe Phe Val  Leu Ser Tyr 
    2270                 2275                 2280             


His Ala  Tyr Gln Leu Arg Val  Cys Gln Pro Pro Pro  Pro Val Pro 
    2285                 2290                 2295             


Asn Ala  Glu Ile Leu Thr Glu  Asp Asp Glu Phe Glu  Ile Gly Asp 
    2300                 2305                 2310             


Ile Ile  Arg Tyr Gln Cys Leu  Pro Gly Phe Thr Leu  Val Gly Asn 
    2315                 2320                 2325             


Ala Ile  Leu Thr Cys Arg Leu  Gly Glu Arg Leu Gln  Met Asp Gly 
    2330                 2335                 2340             


Ala Pro  Pro Val Cys Gln Val  Leu Cys Pro Ala Asn  Glu Leu Arg 
    2345                 2350                 2355             


Leu Asp  Ser Thr Gly Val Ile  Leu Ser Pro Gly Tyr  Pro Asp Ser 
    2360                 2365                 2370             


Tyr Pro  Asn Leu Gln Met Cys  Ala Trp Ser Ile Ser  Val Glu Lys 
    2375                 2380                 2385             


Gly Tyr  Asn Ile Thr Met Phe  Val Glu Phe Phe Gln  Thr Glu Lys 
    2390                 2395                 2400             


Glu Phe  Asp Val Leu Gln Val  Tyr Asp Gly Pro Asn  Ile Gln Ser 
    2405                 2410                 2415             


Pro Val  Leu Ile Ser Leu Ser  Gly Asp Tyr Ser Ser  Ala Phe Asn 
    2420                 2425                 2430             


Ile Thr  Ser Asn Gly His Glu  Val Phe Leu Gln Trp  Ser Ala Asp 
    2435                 2440                 2445             


His Gly  Asn Asn Lys Lys Gly  Phe Arg Ile Arg Tyr  Ile Ala Phe 
    2450                 2455                 2460             


Tyr Cys  Ser Thr Pro Glu Ser  Pro Pro His Gly Tyr  Ile Ile Ser 
    2465                 2470                 2475             


Gln Thr  Gly Gly Gln Leu Asn  Ser Val Val Arg Trp  Ala Cys Asp 
    2480                 2485                 2490             


Arg Gly  Phe Arg Leu Val Gly  Lys Ser Ser Ala Val  Cys Arg Lys 
    2495                 2500                 2505             


Ser Ser  Tyr Gly Tyr His Ala  Trp Asp Ala Pro Val  Pro Ala Cys 
    2510                 2515                 2520             


Gln Ala  Ile Ser Cys Gly Ile  Pro Lys Ala Pro Thr  Asn Gly Gly 
    2525                 2530                 2535             


Ile Leu  Thr Thr Asp Tyr Leu  Val Gly Thr Arg Val  Thr Tyr Phe 
    2540                 2545                 2550             


Cys Asn  Asp Gly Tyr Arg Leu  Ser Ser Lys Glu Leu  Thr Thr Ala 
    2555                 2560                 2565             


Val Cys  Gln Ser Asp Gly Thr  Trp Ser Asn His Asn  Lys Thr Pro 
    2570                 2575                 2580             


Arg Cys  Val Val Ile Ser Cys  Gly Glu Leu Pro Thr  Pro Pro Asn 
    2585                 2590                 2595             


Gly Asn  Lys Ile Gly Thr Gln  Thr Ser Tyr Gly Ser  Thr Ala Ile 
    2600                 2605                 2610             


Phe Thr  Cys Asp Leu Gly Phe  Met Leu Val Gly Ser  Ala Val Arg 
    2615                 2620                 2625             


Glu Cys  Leu Ser Ser Gly Leu  Trp Ser Glu Ser Glu  Thr Arg Cys 
    2630                 2635                 2640             


Leu Ala  Gly His Cys Gly Ile  Pro Glu Leu Ile Val  Asn Gly Gln 
    2645                 2650                 2655             


Val Ile  Gly Glu Asn Tyr Gly  Tyr Arg Asp Thr Val  Val Tyr Gln 
    2660                 2665                 2670             


Cys Asn  Pro Gly Phe Arg Leu  Ile Gly Ser Ser Val  Arg Ile Cys 
    2675                 2680                 2685             


Gln Gln  Asp His Asn Trp Ser  Gly Gln Leu Pro Ser  Cys Val Pro 
    2690                 2695                 2700             


Val Ser  Cys Gly His Pro Gly  Ser Pro Ile Tyr Gly  Arg Thr Ser 
    2705                 2710                 2715             


Gly Asn  Gly Phe Asn Phe Asn  Asp Val Val Thr Phe  Ser Cys Asn 
    2720                 2725                 2730             


Ile Gly  Tyr Leu Met Gln Gly  Pro Thr Lys Ala Gln  Cys Gln Ala 
    2735                 2740                 2745             


Asn Arg  Gln Trp Ser His Pro  Pro Pro Met Cys Lys  Val Val Asn 
    2750                 2755                 2760             


Cys Ser  Asp Pro Gly Ile Pro  Ala Asn Ser Lys Arg  Glu Ser Lys 
    2765                 2770                 2775             


Ile Glu  His Gly Asn Phe Thr  Tyr Gly Thr Val Val  Phe Tyr Asp 
    2780                 2785                 2790             


Cys Asn  Pro Gly Tyr Phe Leu  Phe Gly Ser Ser Val  Leu Ile Cys 
    2795                 2800                 2805             


Gln Pro  Asn Gly Gln Trp Asp  Lys Pro Leu Pro Glu  Cys Ile Met 
    2810                 2815                 2820             


Ile Asp  Cys Gly His Pro Gly  Val Pro Pro Asn Ala  Val Leu Ser 
    2825                 2830                 2835             


Gly Glu  Lys Tyr Thr Phe Gly  Ser Thr Val His Tyr  Ser Cys Thr 
    2840                 2845                 2850             


Gly Lys  Arg Ser Leu Leu Gly  Gln Ser Ser Arg Thr  Cys Gln Leu 
    2855                 2860                 2865             


Asn Gly  His Trp Ser Gly Ser  Gln Pro His Cys Ser  Gly Asp Ala 
    2870                 2875                 2880             


Thr Gly  Thr Cys Gly Asp Pro  Gly Thr Pro Gly His  Gly Ser Arg 
    2885                 2890                 2895             


Gln Glu  Ser Asn Phe Arg Thr  Lys Ser Thr Val Arg  Tyr Ala Cys 
    2900                 2905                 2910             


Asp Thr  Gly Tyr Ile Leu His  Gly Ser Glu Glu Arg  Thr Cys Leu 
    2915                 2920                 2925             


Ala Asn  Gly Ser Trp Thr Gly  Arg Gln Pro Glu Cys  Lys Ala Val 
    2930                 2935                 2940             


Gln Cys  Gly Asn Pro Gly Thr  Thr Ala Asn Gly Lys  Val Phe Arg 
    2945                 2950                 2955             


Ile Asp  Gly Thr Thr Phe Ser  Ser Ser Val Ile Tyr  Ser Cys Met 
    2960                 2965                 2970             


Glu Gly  Tyr Ile Leu Ser Gly  Pro Ser Val Arg Gln  Cys Thr Ala 
    2975                 2980                 2985             


Asn Gly  Thr Trp Ser Gly Thr  Leu Pro Asn Cys Thr  Ile Ile Ser 
    2990                 2995                 3000             


Cys Gly  Asp Pro Gly Ile Pro  Ala Asn Gly Leu Arg  Tyr Gly Asp 
    3005                 3010                 3015             


Asp Tyr  Val Val Gly Gln Asn  Val Ser Tyr Met Cys  Gln Pro Gly 
    3020                 3025                 3030             


Tyr Thr  Met Glu Leu Asn Gly  Ser Arg Ile Arg Thr  Cys Thr Ile 
    3035                 3040                 3045             


Asn Gly  Thr Trp Ser Gly Val  Met Pro Thr Cys Arg  Ala Val Thr 
    3050                 3055                 3060             


Cys Pro  Thr Pro Pro Gln Ile  Ser Asn Gly Arg Leu  Glu Gly Thr 
    3065                 3070                 3075             


Asn Phe  Asp Trp Gly Phe Ser  Ile Ser Tyr Ile Cys  Ser Pro Gly 
    3080                 3085                 3090             


Tyr Glu  Leu Ser Phe Pro Ala  Val Leu Thr Cys Val  Gly Asn Gly 
    3095                 3100                 3105             


Thr Trp  Ser Gly Glu Val Pro  Gln Cys Leu Pro Lys  Phe Cys Gly 
    3110                 3115                 3120             


Asp Pro  Gly Ile Pro Ala Gln  Gly Lys Arg Glu Gly  Lys Ser Phe 
    3125                 3130                 3135             


Ile Tyr  Gln Ser Glu Val Ser  Phe Ser Cys Asn Phe  Pro Phe Ile 
    3140                 3145                 3150             


Leu Val  Gly Ser Ser Thr Arg  Ile Cys Gln Ala Asp  Gly Thr Trp 
    3155                 3160                 3165             


Ser Gly  Ser Ser Pro His Cys  Ile Glu Pro Thr Gln  Thr Ser Cys 
    3170                 3175                 3180             


Glu Asn  Pro Gly Val Pro Arg  His Gly Ser Gln Asn  Asn Thr Phe 
    3185                 3190                 3195             


Gly Phe  Gln Val Gly Ser Val  Val Gln Phe His Cys  Lys Lys Gly 
    3200                 3205                 3210             


His Leu  Leu Gln Gly Ser Thr  Thr Arg Thr Cys Leu  Pro Asp Leu 
    3215                 3220                 3225             


Thr Trp  Ser Gly Ile Gln Pro  Glu Cys Ile Pro His  Ser Cys Lys 
    3230                 3235                 3240             


Gln Pro  Glu Thr Pro Ala His  Ala Asn Val Val Gly  Met Asp Leu 
    3245                 3250                 3255             


Pro Ser  His Gly Tyr Thr Leu  Ile Tyr Thr Cys Gln  Pro Gly Phe 
    3260                 3265                 3270             


Phe Leu  Ala Gly Gly Thr Glu  His Arg Val Cys Arg  Ser Asp Asn 
    3275                 3280                 3285             


Thr Trp  Thr Gly Lys Val Pro  Ile Cys Glu Ala Gly  Ser Lys Ile 
    3290                 3295                 3300             


Leu Val  Lys Asp Pro Arg Pro  Ala Leu Gly Thr Pro  Ser Pro Lys 
    3305                 3310                 3315             


Leu Ser  Val Pro Asp Asp Val  Phe Ala Gln Asn Tyr  Ile Trp Lys 
    3320                 3325                 3330             


Gly Ser  Tyr Asn Phe Lys Gly  Arg Lys Gln Pro Met  Thr Leu Thr 
    3335                 3340                 3345             


Val Thr  Ser Phe Asn Ala Ser  Thr Gly Arg Val Asn  Ala Thr Leu 
    3350                 3355                 3360             


Ser Asn  Ser Asn Met Glu Leu  Leu Leu Ser Gly Val  Tyr Lys Ser 
    3365                 3370                 3375             


Gln Glu  Ala Arg Leu Met Leu  Arg Ile Tyr Leu Ile  Lys Val Pro 
    3380                 3385                 3390             


Ala His  Ala Ser Val Lys Lys  Met Lys Glu Glu Asn  Trp Ala Met 
    3395                 3400                 3405             


Asp Gly  Phe Val Ser Ala Glu  Pro Asp Gly Ala Thr  Tyr Val Phe 
    3410                 3415                 3420             


Gln Gly  Phe Ile Gln Gly Lys  Asp Tyr Gly Gln Phe  Gly Leu Gln 
    3425                 3430                 3435             


Arg Leu  Gly Leu Asn Met Ser  Glu Gly Ser Asn Ser  Ser Asn Gln 
    3440                 3445                 3450             


Pro His  Gly Thr Asn Ser Ser  Ser Val Ala Ile Ala  Ile Leu Val 
    3455                 3460                 3465             


Pro Phe  Phe Ala Leu Ile Phe  Ala Gly Phe Gly Phe  Tyr Leu Tyr 
    3470                 3475                 3480             


Lys Gln  Arg Thr Ala Pro Lys  Thr Gln Tyr Thr Gly  Cys Ser Val 
    3485                 3490                 3495             


His Glu  Asn Asn Asn Gly Gln  Ala Ala Phe Glu Asn  Pro Met Tyr 
    3500                 3505                 3510             


Asp Thr  Asn Ala Lys Ser Val  Glu Gly Lys Ala Val  Arg Phe Asp 
    3515                 3520                 3525             


Pro Asn  Leu Asn Thr Val Cys  Thr Met Val 
    3530                 3535             


<210>  2645
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSN1S1__Homo_sapiens__NP_001020275

<400>  2645

Met Arg Leu Leu Ile Leu Thr Cys Leu Val Ala Val Ala Leu Ala Arg 
1               5                   10                  15      


Pro Lys Leu Pro Leu Arg Tyr Pro Glu Arg Leu Gln Asn Pro Ser Glu 
            20                  25                  30          


Ser Ser Glu Pro Ile Pro Leu Glu Ser Arg Glu Glu Tyr Met Asn Gly 
        35                  40                  45              


Met Asn Arg Arg Asn Ile Leu Arg Glu Lys Gln Thr Asp Glu Ile Lys 
    50                  55                  60                  


Asp Thr Arg Asn Glu Ser Thr Gln Asn Cys Val Val Ala Glu Pro Glu 
65                  70                  75                  80  


Lys Met Glu Ser Ser Ile Ser Ser Ser Ser Glu Glu Gln Phe Cys Arg 
                85                  90                  95      


Leu Asn Glu Tyr Asn Gln Leu Gln Leu Gln Ala Ala His Ala Gln Glu 
            100                 105                 110         


Gln Ile Arg Arg Met Asn Glu Asn Ser His Val Gln Val Pro Phe Gln 
        115                 120                 125             


Gln Leu Asn Gln Leu Ala Ala Tyr Pro Tyr Ala Val Trp Tyr Tyr Pro 
    130                 135                 140                 


Gln Ile Met Gln Tyr Val Pro Phe Pro Pro Phe Ser Asp Ile Ser Asn 
145                 150                 155                 160 


Pro Thr Ala His Glu Asn Tyr Glu Lys Asn Asn Val Met Leu Gln Trp 
                165                 170                 175     


<210>  2646
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSN2__Homo_sapiens__XP_011529920

<400>  2646

Met Lys Val Leu Ile Leu Ala Cys Leu Val Ala Leu Ala Leu Ala Arg 
1               5                   10                  15      


Glu Thr Ile Glu Ser Leu Ser Ser Ser Glu Glu Ser Ile Thr Glu Tyr 
            20                  25                  30          


Lys Gln Lys Val Glu Lys Val Lys His Glu Asp Gln Gln Gln Gly Glu 
        35                  40                  45              


Asp Glu His Gln Asp Lys Ile Tyr Pro Ser Phe Gln Pro Gln Pro Leu 
    50                  55                  60                  


Ile Tyr Pro Phe Val Glu Pro Ile Pro Tyr Gly Phe Leu Pro Gln Asn 
65                  70                  75                  80  


Ile Leu Pro Leu Ala Gln Pro Ala Val Val Leu Pro Val Pro Gln Pro 
                85                  90                  95      


Glu Ile Met Glu Val Pro Lys Ala Lys Asp Thr Val Tyr Thr Lys Gly 
            100                 105                 110         


Arg Val Met Pro Val Leu Lys Ser Pro Thr Ile Pro Phe Phe Asp Pro 
        115                 120                 125             


Gln Ile Pro Lys Leu Thr Asp Leu Glu Asn Leu His Leu Pro Leu Pro 
    130                 135                 140                 


Leu Leu Gln Pro Leu Met Gln Gln Val Pro Gln Pro Ile Pro Gln Thr 
145                 150                 155                 160 


Leu Ala Leu Pro Pro Gln Pro Leu Trp Ser Val Pro Gln Pro Lys Val 
                165                 170                 175     


Leu Pro Ile Pro Gln Gln Val Val Pro Tyr Pro Gln Arg Ala Val Pro 
            180                 185                 190         


Val Gln Ala Leu Leu Leu Asn Gln Glu Leu Leu Leu Asn Pro Thr His 
        195                 200                 205             


Gln Ile Tyr Pro Val Thr Gln Pro Leu Ala Pro Val His Asn Pro Ile 
    210                 215                 220                 


Ser Val 
225     


<210>  2647
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSN3__Homo_sapiens__NP_005203

<400>  2647

Met Lys Ser Phe Leu Leu Val Val Asn Ala Leu Ala Leu Thr Leu Pro 
1               5                   10                  15      


Phe Leu Ala Val Glu Val Gln Asn Gln Lys Gln Pro Ala Cys His Glu 
            20                  25                  30          


Asn Asp Glu Arg Pro Phe Tyr Gln Lys Thr Ala Pro Tyr Val Pro Met 
        35                  40                  45              


Tyr Tyr Val Pro Asn Ser Tyr Pro Tyr Tyr Gly Thr Asn Leu Tyr Gln 
    50                  55                  60                  


Arg Arg Pro Ala Ile Ala Ile Asn Asn Pro Tyr Val Pro Arg Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asn Pro Ala Val Val Arg Pro His Ala Gln Ile Pro Gln Arg 
                85                  90                  95      


Gln Tyr Leu Pro Asn Ser His Pro Pro Thr Val Val Arg Arg Pro Asn 
            100                 105                 110         


Leu His Pro Ser Phe Ile Ala Ile Pro Pro Lys Lys Ile Gln Asp Lys 
        115                 120                 125             


Ile Ile Ile Pro Thr Ile Asn Thr Ile Ala Thr Val Glu Pro Thr Pro 
    130                 135                 140                 


Ala Pro Ala Thr Glu Pro Thr Val Asp Ser Val Val Thr Pro Glu Ala 
145                 150                 155                 160 


Phe Ser Glu Ser Ile Ile Thr Ser Thr Pro Glu Thr Thr Thr Val Ala 
                165                 170                 175     


Val Thr Pro Pro Thr Ala 
            180         


<210>  2648
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSNK1A1__Homo_sapiens__NP_001020276

<400>  2648

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Cys Leu Glu Ser Pro Val Gly Lys 
145                 150                 155                 160 


Arg Lys Arg Ser Met Thr Val Ser Thr Ser Gln Asp Pro Ser Phe Ser 
                165                 170                 175     


Gly Leu Asn Gln Leu Phe Leu Ile Asp Phe Gly Leu Ala Lys Lys Tyr 
            180                 185                 190         


Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg Glu Asp Lys Asn 
        195                 200                 205             


Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met 
225                 230                 235                 240 


Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr 
                245                 250                 255     


Lys Lys Gln Lys Tyr Glu Lys Ile Ser Glu Lys Lys Met Ser Thr Pro 
            260                 265                 270         


Val Glu Val Leu Cys Lys Gly Phe Pro Ala Glu Phe Ala Met Tyr Leu 
        275                 280                 285             


Asn Tyr Cys Arg Gly Leu Arg Phe Glu Glu Ala Pro Asp Tyr Met Tyr 
    290                 295                 300                 


Leu Arg Gln Leu Phe Arg Ile Leu Phe Arg Thr Leu Asn His Gln Tyr 
305                 310                 315                 320 


Asp Tyr Thr Phe Asp Trp Thr Met Leu Lys Gln Lys Ala Ala Gln Gln 
                325                 330                 335     


Ala Ala Ser Ser Ser Gly Gln Gly Gln Gln Ala Gln Thr Pro Thr Gly 
            340                 345                 350         


Lys Gln Thr Asp Lys Thr Lys Ser Asn Met Lys Gly Phe 
        355                 360                 365 


<210>  2649
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSNK1D__Homo_sapiens__NP_001884

<400>  2649

Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly 
1               5                   10                  15      


Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Thr Asp Ile Ala Ala Gly 
            20                  25                  30          


Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Thr Lys His Pro Gln 
        35                  40                  45              


Leu His Ile Glu Ser Lys Ile Tyr Lys Met Met Gln Gly Gly Val Gly 
    50                  55                  60                  


Ile Pro Thr Ile Arg Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met 
65                  70                  75                  80  


Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys 
                85                  90                  95      


Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu Ala Asp Gln Met 
            100                 105                 110         


Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp 
        115                 120                 125             


Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu 
    130                 135                 140                 


Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg 
145                 150                 155                 160 


Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Thr Gly Thr 
                165                 170                 175     


Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile Glu Gln Ser Arg 
            180                 185                 190         


Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu 
        195                 200                 205             


Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Arg Gln Lys 
    210                 215                 220                 


Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro Ile Glu Val Leu 
225                 230                 235                 240 


Cys Lys Gly Tyr Pro Ser Glu Phe Ala Thr Tyr Leu Asn Phe Cys Arg 
                245                 250                 255     


Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu 
            260                 265                 270         


Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe 
        275                 280                 285             


Asp Trp Asn Met Leu Lys Phe Gly Ala Ser Arg Ala Ala Asp Asp Ala 
    290                 295                 300                 


Glu Arg Glu Arg Arg Asp Arg Glu Glu Arg Leu Arg His Ser Arg Asn 
305                 310                 315                 320 


Pro Ala Thr Arg Gly Leu Pro Ser Thr Ala Ser Gly Arg Leu Arg Gly 
                325                 330                 335     


Thr Gln Glu Val Ala Pro Pro Thr Pro Leu Thr Pro Thr Ser His Thr 
            340                 345                 350         


Ala Asn Thr Ser Pro Arg Pro Val Ser Gly Met Glu Arg Glu Arg Lys 
        355                 360                 365             


Val Ser Met Arg Leu His Arg Gly Ala Pro Val Asn Ile Ser Ser Ser 
    370                 375                 380                 


Asp Leu Thr Gly Arg Gln Asp Thr Ser Arg Met Ser Thr Ser Gln Ile 
385                 390                 395                 400 


Pro Gly Arg Val Ala Ser Ser Gly Leu Gln Ser Val Val His Arg 
                405                 410                 415 


<210>  2650
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSNK1G3__Homo_sapiens__NP_001026982

<400>  2650

Met Glu Asn Lys Lys Lys Asp Lys Asp Lys Ser Asp Asp Arg Met Ala 
1               5                   10                  15      


Arg Pro Ser Gly Arg Ser Gly His Asn Thr Arg Gly Thr Gly Ser Ser 
            20                  25                  30          


Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys Lys 
        35                  40                  45              


Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu Tyr 
    50                  55                  60                  


Thr Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Met Lys Ser Arg Ala 
65                  70                  75                  80  


Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser Gly 
                85                  90                  95      


Asp Gly Ile Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys Tyr Asn 
            100                 105                 110         


Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asp 
        115                 120                 125             


Leu Cys Asp Arg Thr Phe Ser Leu Lys Thr Val Leu Met Ile Ala Ile 
    130                 135                 140                 


Gln Leu Ile Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu Ile Tyr 
145                 150                 155                 160 


Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Pro Gly Asn Lys 
                165                 170                 175     


Thr Gln Gln Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys Glu Tyr 
            180                 185                 190         


Ile Asp Pro Glu Thr Lys Lys His Ile Pro Tyr Arg Glu His Lys Ser 
        195                 200                 205             


Leu Thr Gly Thr Ala Arg Tyr Met Ser Ile Asn Thr His Leu Gly Lys 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met Phe Met 
225                 230                 235                 240 


Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Asp Thr 
                245                 250                 255     


Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Thr Lys Arg Ala Thr Pro 
            260                 265                 270         


Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Met Ala Thr Tyr Leu Arg 
        275                 280                 285             


Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr Asp Tyr Leu 
    290                 295                 300                 


Arg Lys Leu Phe Thr Asp Leu Phe Asp Arg Lys Gly Tyr Met Phe Asp 
305                 310                 315                 320 


Tyr Glu Tyr Asp Trp Ile Gly Lys Gln Leu Pro Thr Pro Val Gly Ala 
                325                 330                 335     


Val Gln Gln Asp Pro Ala Leu Ser Ser Asn Arg Glu Ala His Gln His 
            340                 345                 350         


Arg Asp Lys Met Gln Gln Ser Lys Asn Gln Val Val Ser Ser Thr Asn 
        355                 360                 365             


Gly Glu Leu Asn Thr Asp Asp Pro Thr Ala Gly Arg Ser Asn Ala Pro 
    370                 375                 380                 


Ile Thr Ala Pro Thr Glu Val Glu Val Met Asp Glu Thr Asn Cys Gln 
385                 390                 395                 400 


Lys Val Leu Asn Met Trp Cys Cys Cys Phe Phe Lys Arg Arg Lys Arg 
                405                 410                 415     


Lys Thr Ile Gln Arg His Lys 
            420             


<210>  2651
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSNK2A1__Homo_sapiens__XP_011527477

<400>  2651

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala 
        355                 360                 365             


Gly Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro 
    370                 375                 380                 


Ala Ala Ala Gly Ala Gln Gln 
385                 390     


<210>  2652
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSNK2A2__Homo_sapiens__NP_001887

<400>  2652

Met Pro Gly Pro Ala Ala Gly Ser Arg Ala Arg Val Tyr Ala Glu Val 
1               5                   10                  15      


Asn Ser Leu Arg Ser Arg Glu Tyr Trp Asp Tyr Glu Ala His Val Pro 
            20                  25                  30          


Ser Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg 
        35                  40                  45              


Gly Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu 
    50                  55                  60                  


Arg Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys 
65                  70                  75                  80  


Arg Glu Val Lys Ile Leu Glu Asn Leu Arg Gly Gly Thr Asn Ile Ile 
                85                  90                  95      


Lys Leu Ile Asp Thr Val Lys Asp Pro Val Ser Lys Thr Pro Ala Leu 
            100                 105                 110         


Val Phe Glu Tyr Ile Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Ile 
        115                 120                 125             


Leu Thr Asp Phe Asp Ile Arg Phe Tyr Met Tyr Glu Leu Leu Lys Ala 
    130                 135                 140                 


Leu Asp Tyr Cys His Ser Lys Gly Ile Met His Arg Asp Val Lys Pro 
145                 150                 155                 160 


His Asn Val Met Ile Asp His Gln Gln Lys Lys Leu Arg Leu Ile Asp 
                165                 170                 175     


Trp Gly Leu Ala Glu Phe Tyr His Pro Ala Gln Glu Tyr Asn Val Arg 
            180                 185                 190         


Val Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln 
        195                 200                 205             


Met Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala 
    210                 215                 220                 


Ser Met Ile Phe Arg Arg Glu Pro Phe Phe His Gly Gln Asp Asn Tyr 
225                 230                 235                 240 


Asp Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Glu Leu Tyr 
                245                 250                 255     


Gly Tyr Leu Lys Lys Tyr His Ile Asp Leu Asp Pro His Phe Asn Asp 
            260                 265                 270         


Ile Leu Gly Gln His Ser Arg Lys Arg Trp Glu Asn Phe Ile His Ser 
        275                 280                 285             


Glu Asn Arg His Leu Val Ser Pro Glu Ala Leu Asp Leu Leu Asp Lys 
    290                 295                 300                 


Leu Leu Arg Tyr Asp His Gln Gln Arg Leu Thr Ala Lys Glu Ala Met 
305                 310                 315                 320 


Glu His Pro Tyr Phe Tyr Pro Val Val Lys Glu Gln Ser Gln Pro Cys 
                325                 330                 335     


Ala Asp Asn Ala Val Leu Ser Ser Gly Leu Thr Ala Ala Arg 
            340                 345                 350 


<210>  2653
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSNK2B__Homo_sapiens__NP_001311

<400>  2653

Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Thr Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Arg Tyr Ile Leu Thr Asn Arg Gly Ile Ala Gln 
                85                  90                  95      


Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
            100                 105                 110         


Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
        115                 120                 125             


Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
    130                 135                 140                 


Thr Pro Lys Ser Ser Arg His His His Thr Asp Gly Ala Tyr Phe Gly 
145                 150                 155                 160 


Thr Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                165                 170                 175     


Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
            180                 185                 190         


His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
        195                 200                 205             


Ser Pro Val Lys Thr Ile Arg 
    210                 215 


<210>  2654
<211>  2322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSPG4__Homo_sapiens__NP_001888

<400>  2654

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  2655
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSPG5__Homo_sapiens__NP_001193871

<400>  2655

Met Pro Pro Ala Ile Pro Glu Ala Thr Glu Ala Ser Gly Pro Pro Ser 
1               5                   10                  15      


Pro Thr Pro Gly Asp Lys Leu Ser Pro Ala Ser Glu Leu Pro Lys Glu 
            20                  25                  30          


Ser Pro Leu Glu Val Trp Leu Asn Leu Gly Gly Ser Thr Pro Asp Pro 
        35                  40                  45              


Gln Gly Pro Glu Leu Thr Tyr Pro Phe Gln Gly Thr Leu Glu Pro Gln 
    50                  55                  60                  


Pro Ala Ser Asp Ile Ile Asp Ile Asp Tyr Phe Glu Gly Leu Asp Gly 
65                  70                  75                  80  


Glu Gly Arg Gly Ala Asp Leu Gly Ser Phe Pro Gly Ser Pro Gly Thr 
                85                  90                  95      


Ser Glu Asn His Pro Asp Thr Glu Gly Glu Thr Pro Ser Trp Ser Leu 
            100                 105                 110         


Leu Asp Leu Tyr Asp Asp Phe Thr Pro Phe Asp Glu Ser Asp Phe Tyr 
        115                 120                 125             


Pro Thr Thr Ser Phe Tyr Asp Asp Leu Asp Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Asp Asp Lys Asp Ala Val Gly Gly Gly Asp Leu Glu Asp Glu Asn 
145                 150                 155                 160 


Glu Leu Leu Val Pro Thr Gly Lys Pro Gly Leu Gly Pro Gly Thr Gly 
                165                 170                 175     


Gln Pro Thr Ser Arg Trp His Ala Val Pro Pro Gln His Thr Leu Gly 
            180                 185                 190         


Ser Val Pro Gly Ser Ser Ile Ala Leu Arg Pro Arg Pro Gly Glu Pro 
        195                 200                 205             


Gly Arg Asp Leu Ala Ser Ser Glu Asn Gly Thr Glu Cys Arg Ser Gly 
    210                 215                 220                 


Phe Val Arg His Asn Gly Ser Cys Arg Ser Val Cys Asp Leu Phe Pro 
225                 230                 235                 240 


Ser Tyr Cys His Asn Gly Gly Gln Cys Tyr Leu Val Glu Asn Ile Gly 
                245                 250                 255     


Ala Phe Cys Arg Cys Asn Thr Gln Asp Tyr Ile Trp His Lys Gly Met 
            260                 265                 270         


Arg Cys Glu Ser Ile Ile Thr Asp Phe Gln Val Met Cys Val Ala Val 
        275                 280                 285             


Gly Ser Ala Ala Leu Val Leu Leu Leu Leu Phe Met Met Thr Val Phe 
    290                 295                 300                 


Phe Ala Lys Lys Leu Tyr Leu Leu Lys Thr Glu Asn Thr Lys Leu Arg 
305                 310                 315                 320 


Arg Thr Asn Lys Phe Arg Thr Pro Ser Glu Leu His Asn Asp Asn Phe 
                325                 330                 335     


Ser Leu Ser Thr Ile Ala Glu Gly Ser His Pro Asn Asp Asp Pro Ser 
            340                 345                 350         


Ala Pro His Lys Ile Gln Glu Val Leu Lys Ser Cys Leu Lys Glu Glu 
        355                 360                 365             


Glu Ser Phe Asn Ile Gln Asn Ser Met Ser Pro Lys Leu Glu Gly Gly 
    370                 375                 380                 


Lys Gly Asp Gln Ala Asp Leu Asp Val Asn Cys Leu Gln Asn Asn Leu 
385                 390                 395                 400 


Thr 
    


<210>  2656
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSPP1__Homo_sapiens__NP_001278268

<400>  2656

Met Asp Glu Arg Phe Arg Tyr Glu Ser Asp Phe Asp Arg Arg Leu Ser 
1               5                   10                  15      


Arg Val Tyr Thr Asn Asp Arg Met His Arg Asn Lys Arg Gly Asn Met 
            20                  25                  30          


Pro Pro Met Glu His Asp Gly Asp Val Ile Glu Gln Ser Asn Ile Arg 
        35                  40                  45              


Ile Ser Ser Ala Glu Asn Lys Ser Ala Pro Asp Asn Glu Thr Ser Lys 
    50                  55                  60                  


Ser Ala Asn Gln Asp Thr Cys Ser Pro Phe Ala Gly Met Leu Phe Gly 
65                  70                  75                  80  


Gly Glu Asp Arg Glu Leu Ile Gln Arg Arg Lys Glu Lys Tyr Arg Leu 
                85                  90                  95      


Glu Leu Leu Glu Gln Met Ala Glu Gln Gln Arg Asn Lys Arg Arg Glu 
            100                 105                 110         


Lys Asp Leu Glu Leu Arg Val Ala Ala Ser Gly Ala Gln Asp Pro Glu 
        115                 120                 125             


Lys Ser Pro Asp Arg Leu Lys Gln Phe Ser Val Ala Pro Arg His Phe 
    130                 135                 140                 


Glu Glu Met Ile Pro Pro Glu Arg Pro Arg Ile Ala Phe Gln Thr Pro 
145                 150                 155                 160 


Leu Pro Pro Leu Ser Ala Pro Ser Val Pro Pro Ile Pro Ser Val His 
                165                 170                 175     


Pro Val Pro Ser Gln Asn Glu Asp Leu Arg Ser Gly Leu Ser Ser Ala 
            180                 185                 190         


Leu Gly Glu Met Val Ser Pro Arg Ile Ala Pro Leu Pro Pro Pro Pro 
        195                 200                 205             


Leu Leu Pro Pro Leu Ala Thr Asn Tyr Arg Thr Pro Tyr Asp Asp Ala 
    210                 215                 220                 


Tyr Tyr Phe Tyr Gly Ser Arg Asn Thr Phe Asp Pro Ser Leu Ala Tyr 
225                 230                 235                 240 


Tyr Gly Ser Gly Met Met Gly Val Gln Pro Ala Ala Tyr Val Ser Ala 
                245                 250                 255     


Pro Val Thr His Gln Leu Ala Gln Pro Val Val Asn Thr Val Gly Gln 
            260                 265                 270         


Asn Glu Leu Lys Ile Thr Ser Asp Gln Val Ile Asn Ser Gly Leu Ile 
        275                 280                 285             


Phe Glu Asp Lys Pro Lys Pro Ser Lys Gln Ser Leu Gln Ser Tyr Gln 
    290                 295                 300                 


Glu Ala Leu Gln Gln Gln Ile Arg Glu Arg Glu Glu Arg Arg Lys Lys 
305                 310                 315                 320 


Glu Arg Glu Glu Lys Glu Glu Tyr Glu Ala Lys Leu Glu Ala Glu Met 
                325                 330                 335     


Arg Thr Tyr Asn Pro Trp Gly Lys Gly Gly Gly Gly Ala Pro Leu Arg 
            340                 345                 350         


Asp Ala Lys Gly Asn Leu Ile Ser His Met Gln Thr Gln Ser Ser Pro 
        355                 360                 365             


Phe Ala Arg Gly Asn Val Phe Gly Glu Pro Pro Thr Glu Leu Gln Ile 
    370                 375                 380                 


Lys Gln Gln Glu Leu Tyr Lys Asn Phe Leu Arg Phe Gln Ile Glu Glu 
385                 390                 395                 400 


Lys Lys Gln Arg Glu Glu Ala Glu Arg Glu Arg Leu Arg Ile Ala Glu 
                405                 410                 415     


Glu Lys Glu Glu Arg Arg Leu Ala Glu Gln Arg Ala Arg Ile Gln Gln 
            420                 425                 430         


Glu Tyr Glu Glu Glu Gln Glu Lys Lys Arg Glu Lys Glu Glu Glu Gln 
        435                 440                 445             


Arg Leu Lys Asn Glu Glu His Ile Arg Leu Ala Glu Glu Arg Gln Lys 
    450                 455                 460                 


Glu Ala Glu Arg Lys Lys Lys Glu Glu Glu Glu Lys Tyr Asn Leu Gln 
465                 470                 475                 480 


Leu Gln His Tyr Cys Glu Arg Asp Asn Leu Ile Gly Glu Glu Thr Lys 
                485                 490                 495     


His Met Arg Gln Pro Ser Pro Ile Val Pro Ala Leu Gln Asn Lys Ile 
            500                 505                 510         


Ala Ser Lys Leu Gln Arg Pro Pro Ser Val Asp Ser Ile Ile Arg Ser 
        515                 520                 525             


Phe Ile His Glu Ser Ser Met Ser Arg Ala Gln Ser Pro Pro Val Pro 
    530                 535                 540                 


Ala Arg Lys Asn Gln Leu Arg Ala Glu Glu Glu Lys Lys Asn Val Ile 
545                 550                 555                 560 


Met Glu Leu Ser Glu Met Arg Lys Gln Leu Arg Ser Glu Glu Arg Arg 
                565                 570                 575     


Leu Gln Glu Arg Leu Leu His Met Asp Ser Asp Asp Glu Ile Pro Ile 
            580                 585                 590         


Arg Lys Lys Glu Arg Asn Pro Met Asp Ile Phe Asp Met Ala Arg His 
        595                 600                 605             


Arg Leu Gln Ala Pro Val Arg Arg Gln Ser Pro Lys Gly Leu Asp Ala 
    610                 615                 620                 


Ala Thr Phe Gln Asn Val His Asp Phe Asn Glu Leu Lys Asp Arg Asp 
625                 630                 635                 640 


Ser Glu Thr Arg Val Asp Leu Lys Phe Met Tyr Leu Asp Pro Pro Arg 
                645                 650                 655     


Asp His His Thr Leu Glu Ile Gln Gln Gln Ala Leu Leu Arg Glu Gln 
            660                 665                 670         


Gln Lys Arg Leu Asn Arg Ile Lys Met Gln Glu Gly Ala Lys Val Asp 
        675                 680                 685             


Leu Asp Ala Ile Pro Ser Ala Lys Val Arg Glu Gln Arg Met Pro Arg 
    690                 695                 700                 


Asp Asp Thr Ser Asp Phe Leu Lys Asn Ser Leu Leu Glu Ser Asp Ser 
705                 710                 715                 720 


Ala Phe Ile Gly Ala Tyr Gly Glu Thr Tyr Pro Ala Ile Glu Asp Asp 
                725                 730                 735     


Val Leu Pro Pro Pro Ser Gln Leu Pro Ser Ala Arg Glu Arg Arg Arg 
            740                 745                 750         


Asn Lys Trp Lys Gly Leu Asp Ile Asp Ser Ser Arg Pro Asn Val Ala 
        755                 760                 765             


Pro Asp Gly Leu Ser Leu Lys Ser Ile Ser Ser Val Asn Val Asp Glu 
    770                 775                 780                 


Leu Arg Val Arg Asn Glu Glu Arg Met Arg Arg Leu Asn Glu Phe His 
785                 790                 795                 800 


Asn Lys Pro Ile Asn Thr Asp Asp Glu Ser Ser Leu Val Asp Pro Asp 
                805                 810                 815     


Asp Ile Met Lys His Ile Gly Asp Asp Gly Ser Asn Ser Val Ala Thr 
            820                 825                 830         


Glu Pro Trp Leu Arg Pro Gly Thr Ser Glu Thr Leu Lys Arg Phe Met 
        835                 840                 845             


Ala Glu Gln Leu Asn Gln Glu Gln Gln Gln Ile Pro Gly Lys Pro Gly 
    850                 855                 860                 


Thr Phe Thr Trp Gln Gly Leu Ser Thr Ala His Gly 
865                 870                 875     


<210>  2657
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSRNP1__Homo_sapiens__NP_149016

<400>  2657

Met Thr Gly Leu Leu Lys Arg Lys Phe Asp Gln Leu Asp Glu Asp Asn 
1               5                   10                  15      


Ser Ser Val Ser Ser Ser Ser Ser Ser Ser Gly Cys Gln Ser Arg Ser 
            20                  25                  30          


Cys Ser Pro Ser Ser Ser Val Ser Arg Ala Trp Asp Ser Glu Glu Glu 
        35                  40                  45              


Gly Pro Trp Asp Gln Met Pro Leu Pro Asp Arg Asp Phe Cys Gly Pro 
    50                  55                  60                  


Arg Ser Phe Thr Pro Leu Ser Ile Leu Lys Arg Ala Arg Arg Glu Arg 
65                  70                  75                  80  


Pro Gly Arg Val Ala Phe Asp Gly Ile Thr Val Phe Tyr Phe Pro Arg 
                85                  90                  95      


Cys Gln Gly Phe Thr Ser Val Pro Ser Arg Gly Gly Cys Thr Leu Gly 
            100                 105                 110         


Met Ala Leu Arg His Ser Ala Cys Arg Arg Phe Ser Leu Ala Glu Phe 
        115                 120                 125             


Ala Gln Glu Gln Ala Arg Ala Arg His Glu Lys Leu Arg Gln Arg Leu 
    130                 135                 140                 


Lys Glu Glu Lys Leu Glu Met Leu Gln Trp Lys Leu Ser Ala Ala Gly 
145                 150                 155                 160 


Val Pro Gln Ala Glu Ala Gly Leu Pro Pro Val Val Asp Ala Ile Asp 
                165                 170                 175     


Asp Ala Ser Val Glu Glu Asp Leu Ala Val Ala Val Ala Gly Gly Arg 
            180                 185                 190         


Leu Glu Glu Val Ser Phe Leu Gln Pro Tyr Pro Ala Arg Arg Arg Arg 
        195                 200                 205             


Ala Leu Leu Arg Ala Ser Gly Val Arg Arg Ile Asp Arg Glu Glu Lys 
    210                 215                 220                 


Arg Glu Leu Gln Ala Leu Arg Gln Ser Arg Glu Asp Cys Gly Cys His 
225                 230                 235                 240 


Cys Asp Arg Ile Cys Asp Pro Glu Thr Cys Ser Cys Ser Leu Ala Gly 
                245                 250                 255     


Ile Lys Cys Gln Met Asp His Thr Ala Phe Pro Cys Gly Cys Cys Arg 
            260                 265                 270         


Glu Gly Cys Glu Asn Pro Met Gly Arg Val Glu Phe Asn Gln Ala Arg 
        275                 280                 285             


Val Gln Thr His Phe Ile His Thr Leu Thr Arg Leu Gln Leu Glu Gln 
    290                 295                 300                 


Glu Ala Glu Ser Phe Arg Glu Leu Glu Ala Pro Ala Gln Gly Ser Pro 
305                 310                 315                 320 


Pro Ser Pro Gly Glu Glu Ala Leu Val Pro Thr Phe Pro Leu Ala Lys 
                325                 330                 335     


Pro Pro Met Asn Asn Glu Leu Gly Asp Asn Ser Cys Ser Ser Asp Met 
            340                 345                 350         


Thr Asp Ser Ser Thr Ala Ser Ser Ser Ala Ser Gly Thr Ser Glu Ala 
        355                 360                 365             


Pro Asp Cys Pro Thr His Pro Gly Leu Pro Gly Pro Gly Phe Gln Pro 
    370                 375                 380                 


Gly Val Asp Asp Asp Ser Leu Ala Arg Ile Leu Ser Phe Ser Asp Ser 
385                 390                 395                 400 


Asp Phe Gly Gly Glu Glu Glu Glu Glu Glu Glu Gly Ser Val Gly Asn 
                405                 410                 415     


Leu Asp Asn Leu Ser Cys Phe His Pro Ala Asp Ile Phe Gly Thr Ser 
            420                 425                 430         


Asp Pro Gly Gly Leu Ala Ser Trp Thr His Ser Tyr Ser Gly Cys Ser 
        435                 440                 445             


Phe Thr Ser Gly Val Leu Asp Glu Asn Ala Asn Leu Asp Ala Ser Cys 
    450                 455                 460                 


Phe Leu Asn Gly Gly Leu Glu Gly Ser Arg Glu Gly Ser Leu Pro Gly 
465                 470                 475                 480 


Thr Ser Val Pro Pro Ser Met Asp Ala Gly Arg Ser Ser Ser Val Asp 
                485                 490                 495     


Leu Ser Leu Ser Ser Cys Asp Ser Phe Glu Leu Leu Gln Ala Leu Pro 
            500                 505                 510         


Asp Tyr Ser Leu Gly Pro His Tyr Thr Ser Gln Lys Val Ser Asp Ser 
        515                 520                 525             


Leu Asp Asn Ile Glu Ala Pro His Phe Pro Leu Pro Gly Leu Ser Pro 
    530                 535                 540                 


Pro Gly Asp Ala Ser Ser Cys Phe Leu Glu Ser Leu Met Gly Phe Ser 
545                 550                 555                 560 


Glu Pro Ala Ala Glu Ala Leu Asp Pro Phe Ile Asp Ser Gln Phe Glu 
                565                 570                 575     


Asp Thr Val Pro Ala Ser Leu Met Glu Pro Val Pro Val 
            580                 585                 


<210>  2658
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSRNP3__Homo_sapiens__NP_079245

<400>  2658

Met Ser Gly Ile Leu Lys Arg Lys Phe Glu Glu Val Asp Gly Ser Ser 
1               5                   10                  15      


Pro Cys Ser Ser Val Arg Glu Ser Asp Asp Glu Val Ser Ser Ser Glu 
            20                  25                  30          


Ser Ala Asp Ser Gly Asp Ser Val Asn Pro Ser Thr Ser Ser His Phe 
        35                  40                  45              


Thr Pro Ser Ser Ile Leu Lys Arg Glu Lys Arg Leu Arg Thr Lys Asn 
    50                  55                  60                  


Val His Phe Ser Cys Val Thr Val Tyr Tyr Phe Thr Arg Arg Gln Gly 
65                  70                  75                  80  


Phe Thr Ser Val Pro Ser Gln Gly Gly Ser Thr Leu Gly Met Ser Ser 
                85                  90                  95      


Arg His Asn Ser Val Arg Gln Tyr Thr Leu Gly Glu Phe Ala Arg Glu 
            100                 105                 110         


Gln Glu Arg Leu His Arg Glu Met Leu Arg Glu His Leu Arg Glu Glu 
        115                 120                 125             


Lys Leu Asn Ser Leu Lys Leu Lys Met Thr Lys Asn Gly Thr Val Glu 
    130                 135                 140                 


Ser Glu Glu Ala Ser Thr Leu Thr Leu Asp Asp Ile Ser Asp Asp Asp 
145                 150                 155                 160 


Ile Asp Leu Asp Asn Thr Glu Val Asp Glu Tyr Phe Phe Leu Gln Pro 
                165                 170                 175     


Leu Pro Thr Lys Lys Arg Arg Ala Leu Leu Arg Ala Ser Gly Val Lys 
            180                 185                 190         


Lys Ile Asp Val Glu Glu Lys His Glu Leu Arg Ala Ile Arg Leu Ser 
        195                 200                 205             


Arg Glu Asp Cys Gly Cys Asp Cys Arg Val Phe Cys Asp Pro Asp Thr 
    210                 215                 220                 


Cys Thr Cys Ser Leu Ala Gly Ile Lys Cys Gln Val Asp Arg Met Ser 
225                 230                 235                 240 


Phe Pro Cys Gly Cys Thr Lys Glu Gly Cys Ser Asn Thr Ala Gly Arg 
                245                 250                 255     


Ile Glu Phe Asn Pro Ile Arg Val Arg Thr His Phe Leu His Thr Ile 
            260                 265                 270         


Met Lys Leu Glu Leu Glu Lys Asn Arg Glu Gln Gln Ile Pro Thr Leu 
        275                 280                 285             


Asn Gly Cys His Ser Glu Ile Ser Ala His Ser Ser Ser Met Gly Pro 
    290                 295                 300                 


Val Ala His Ser Val Glu Tyr Ser Ile Ala Asp Ser Phe Glu Ile Glu 
305                 310                 315                 320 


Thr Glu Pro Gln Ala Ala Val Leu His Leu Gln Ser Ala Glu Glu Leu 
                325                 330                 335     


Asp Cys Gln Gly Glu Glu Glu Glu Glu Glu Glu Asp Gly Ser Ser Phe 
            340                 345                 350         


Cys Ser Gly Val Thr Asp Ser Ser Thr Gln Ser Leu Ala Pro Ser Glu 
        355                 360                 365             


Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    370                 375                 380                 


Asp Asp Asp Asp Lys Gly Asp Gly Phe Val Glu Gly Leu Gly Thr His 
385                 390                 395                 400 


Ala Glu Val Val Pro Leu Pro Ser Val Leu Cys Tyr Ser Asp Gly Thr 
                405                 410                 415     


Ala Val His Glu Ser His Ala Lys Asn Ala Ser Phe Tyr Ala Asn Ser 
            420                 425                 430         


Ser Thr Leu Tyr Tyr Gln Ile Asp Ser His Ile Pro Gly Thr Pro Asn 
        435                 440                 445             


Gln Ile Ser Glu Asn Tyr Ser Glu Arg Asp Thr Val Lys Asn Gly Thr 
    450                 455                 460                 


Leu Ser Leu Val Pro Tyr Thr Met Thr Pro Glu Gln Phe Val Asp Tyr 
465                 470                 475                 480 


Ala Arg Gln Ala Glu Glu Ala Tyr Gly Ala Ser His Tyr Pro Ala Ala 
                485                 490                 495     


Asn Pro Ser Val Ile Val Cys Cys Ser Ser Ser Glu Asn Asp Ser Gly 
            500                 505                 510         


Val Pro Cys Asn Ser Leu Tyr Pro Glu His Arg Ser Asn His Pro Gln 
        515                 520                 525             


Val Glu Phe His Ser Tyr Leu Lys Gly Pro Ser Gln Glu Gly Phe Val 
    530                 535                 540                 


Ser Ala Leu Asn Gly Asp Ser His Ile Ser Glu His Pro Ala Glu Asn 
545                 550                 555                 560 


Ser Leu Ser Leu Ala Glu Lys Ser Ile Leu His Glu Glu Cys Ile Lys 
                565                 570                 575     


Ser Pro Val Val Glu Thr Val Pro Val 
            580                 585 


<210>  2659
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSRP1__Homo_sapiens__NP_001180500

<400>  2659

Met Pro Asn Trp Gly Gly Gly Lys Lys Cys Gly Val Cys Gln Lys Thr 
1               5                   10                  15      


Val Tyr Phe Ala Glu Glu Val Gln Cys Glu Gly Asn Ser Phe His Lys 
            20                  25                  30          


Ser Cys Phe Leu Cys Met Val Cys Lys Lys Asn Leu Asp Ser Thr Thr 
        35                  40                  45              


Val Ala Val His Gly Glu Glu Ile Tyr Cys Lys Ser Cys Tyr Gly Lys 
    50                  55                  60                  


Lys Tyr Gly Pro Lys Gly Tyr Gly Tyr Gly Gln Gly Ala Gly Thr Leu 
65                  70                  75                  80  


Ser Thr Asp Lys Gly Glu Ser Leu Gly Ile Lys His Glu Glu Ala Pro 
                85                  90                  95      


Gly His Arg Pro Thr Thr Asn Pro Asn Ala Ser Lys Phe Ala Gln Lys 
            100                 105                 110         


Ile Gly Gly Ser Glu Arg Cys Pro Arg Cys Ser Gln Ala Val Tyr Ala 
        115                 120                 125             


Ala Glu Lys Val Ile Gly Ala Gly Lys Ser Trp His Lys Ala Cys Phe 
    130                 135                 140                 


Arg Cys Ala Lys Cys Gly Lys Gly Leu Glu Ser Thr Thr Leu Ala Asp 
145                 150                 155                 160 


Lys Asp Gly Glu Ile Tyr Cys Lys Gly Cys Tyr Ala Lys Asn Phe Gly 
                165                 170                 175     


Pro Lys Gly Phe Gly Phe Gly Gln Gly Ala Gly Ala Leu Val His Ser 
            180                 185                 190         


Glu 
    


<210>  2660
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSRP2BP__Homo_sapiens__NP_065397

<400>  2660

Met Asp Ser Ser Ile His Leu Ser Ser Leu Ile Ser Arg His Asp Asp 
1               5                   10                  15      


Glu Ala Thr Arg Thr Ser Thr Ser Glu Gly Leu Glu Glu Gly Glu Val 
            20                  25                  30          


Glu Gly Glu Thr Leu Leu Ile Val Glu Ser Glu Asp Gln Ala Ser Val 
        35                  40                  45              


Asp Leu Ser His Asp Gln Ser Gly Asp Ser Leu Asn Ser Asp Glu Gly 
    50                  55                  60                  


Asp Val Ser Trp Met Glu Glu Gln Leu Ser Tyr Phe Cys Asp Lys Cys 
65                  70                  75                  80  


Gln Lys Trp Ile Pro Ala Ser Gln Leu Arg Glu Gln Leu Ser Tyr Leu 
                85                  90                  95      


Lys Gly Asp Asn Phe Phe Arg Phe Thr Cys Ser Asp Cys Ser Ala Asp 
            100                 105                 110         


Gly Lys Glu Gln Tyr Glu Arg Leu Lys Leu Thr Trp Gln Gln Val Val 
        115                 120                 125             


Met Leu Ala Met Tyr Asn Leu Ser Leu Glu Gly Ser Gly Arg Gln Gly 
    130                 135                 140                 


Tyr Phe Arg Trp Lys Glu Asp Ile Cys Ala Phe Ile Glu Lys His Trp 
145                 150                 155                 160 


Thr Phe Leu Leu Gly Asn Arg Lys Lys Thr Ser Thr Trp Trp Ser Thr 
                165                 170                 175     


Val Ala Gly Cys Leu Ser Val Gly Ser Pro Met Tyr Phe Arg Ser Gly 
            180                 185                 190         


Ala Gln Glu Phe Gly Glu Pro Gly Trp Trp Lys Leu Val His Asn Lys 
        195                 200                 205             


Pro Pro Thr Met Lys Pro Glu Gly Glu Lys Leu Ser Ala Ser Thr Leu 
    210                 215                 220                 


Lys Ile Lys Ala Ala Ser Lys Pro Thr Leu Asp Pro Ile Ile Thr Val 
225                 230                 235                 240 


Glu Gly Leu Arg Lys Arg Ala Ser Arg Asn Pro Val Glu Ser Ala Met 
                245                 250                 255     


Glu Leu Lys Glu Lys Arg Ser Arg Thr Gln Glu Ala Lys Asp Ile Arg 
            260                 265                 270         


Arg Ala Gln Lys Glu Ala Ala Gly Phe Leu Asp Arg Ser Thr Ser Ser 
        275                 280                 285             


Thr Pro Val Lys Phe Ile Ser Arg Gly Arg Arg Pro Asp Val Ile Leu 
    290                 295                 300                 


Glu Lys Gly Glu Val Ile Asp Phe Ser Ser Leu Ser Ser Ser Asp Arg 
305                 310                 315                 320 


Thr Pro Leu Thr Ser Pro Ser Pro Ser Pro Ser Leu Asp Phe Ser Ala 
                325                 330                 335     


Pro Gly Thr Pro Ala Ser His Ser Ala Thr Pro Ser Leu Leu Ser Glu 
            340                 345                 350         


Ala Asp Leu Ile Pro Asp Val Met Pro Pro Gln Ala Leu Phe His Asp 
        355                 360                 365             


Asp Asp Glu Met Glu Gly Asp Gly Val Ile Asp Pro Gly Met Glu Tyr 
    370                 375                 380                 


Val Pro Pro Pro Ala Gly Ser Val Ala Ser Gly Pro Val Val Gly Gly 
385                 390                 395                 400 


Arg Lys Lys Val Arg Gly Pro Glu Gln Ile Lys Gln Glu Val Glu Ser 
                405                 410                 415     


Glu Glu Glu Lys Pro Asp Arg Met Asp Ile Asp Ser Glu Asp Thr Asp 
            420                 425                 430         


Ser Asn Thr Ser Leu Gln Thr Arg Ala Arg Glu Lys Arg Lys Pro Gln 
        435                 440                 445             


Leu Glu Lys Asp Thr Lys Pro Lys Glu Pro Arg Tyr Thr Pro Val Ser 
    450                 455                 460                 


Ile Tyr Glu Glu Lys Leu Leu Leu Lys Arg Leu Glu Ala Cys Pro Gly 
465                 470                 475                 480 


Ala Val Ala Met Thr Pro Glu Ala Arg Arg Leu Lys Arg Lys Leu Ile 
                485                 490                 495     


Val Arg Gln Ala Lys Arg Asp Arg Gly Leu Pro Leu Phe Asp Leu Asp 
            500                 505                 510         


Gln Val Val Asn Ala Ala Leu Leu Leu Val Asp Gly Ile Tyr Gly Ala 
        515                 520                 525             


Lys Glu Gly Gly Ile Ser Arg Leu Pro Ala Gly Gln Ala Thr Tyr Arg 
    530                 535                 540                 


Thr Thr Cys Gln Asp Phe Arg Ile Leu Asp Arg Tyr Gln Thr Ser Leu 
545                 550                 555                 560 


Pro Ser Arg Lys Gly Phe Arg His Gln Thr Thr Lys Phe Leu Tyr Arg 
                565                 570                 575     


Leu Val Gly Ser Glu Asp Met Ala Val Asp Gln Ser Ile Val Ser Pro 
            580                 585                 590         


Tyr Thr Ser Arg Ile Leu Lys Pro Tyr Ile Arg Arg Asp Tyr Glu Thr 
        595                 600                 605             


Lys Pro Pro Lys Leu Gln Leu Leu Ser Gln Ile Arg Ser His Leu His 
    610                 615                 620                 


Arg Ser Asp Pro His Trp Thr Pro Glu Pro Asp Ala Pro Leu Asp Tyr 
625                 630                 635                 640 


Cys Tyr Val Arg Pro Asn His Ile Pro Thr Ile Asn Ser Met Cys Gln 
                645                 650                 655     


Glu Phe Phe Trp Pro Gly Ile Asp Leu Ser Glu Cys Leu Gln Tyr Pro 
            660                 665                 670         


Asp Phe Ser Val Val Val Leu Tyr Lys Lys Val Ile Ile Ala Phe Gly 
        675                 680                 685             


Phe Met Val Pro Asp Val Lys Tyr Asn Glu Ala Tyr Ile Ser Phe Leu 
    690                 695                 700                 


Phe Val His Pro Glu Trp Arg Arg Ala Gly Ile Ala Thr Phe Met Ile 
705                 710                 715                 720 


Tyr His Leu Ile Gln Thr Cys Met Gly Lys Asp Val Thr Leu His Val 
                725                 730                 735     


Ser Ala Ser Asn Pro Ala Met Leu Leu Tyr Gln Lys Phe Gly Phe Lys 
            740                 745                 750         


Thr Glu Glu Tyr Val Leu Asp Phe Tyr Asp Lys Tyr Tyr Pro Leu Glu 
        755                 760                 765             


Ser Thr Glu Cys Lys His Ala Phe Phe Leu Arg Leu Arg Arg 
    770                 775                 780         


<210>  2661
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSRP2__Homo_sapiens__NP_001287894

<400>  2661

Met Pro Val Trp Gly Gly Gly Asn Lys Cys Gly Ala Cys Gly Arg Thr 
1               5                   10                  15      


Val Tyr His Ala Glu Glu Val Gln Cys Asp Gly Arg Ser Phe His Arg 
            20                  25                  30          


Cys Cys Phe Leu Cys Met Val Cys Arg Lys Asn Leu Asp Ser Thr Thr 
        35                  40                  45              


Val Ala Ile His Asp Glu Glu Ile Tyr Cys Lys Ser Cys Tyr Gly Lys 
    50                  55                  60                  


Lys Tyr Gly Pro Lys Gly Tyr Gly Tyr Gly Gln Gly Ala Gly Thr Leu 
65                  70                  75                  80  


Asn Met Asp Arg Gly Glu Arg Leu Gly Ile Lys Pro Glu Ser Val Gln 
                85                  90                  95      


Pro His Arg Pro Thr Thr Asn Pro Asn Thr Ser Lys Phe Ala Gln Lys 
            100                 105                 110         


Tyr Gly Gly Ala Glu Lys Cys Ser Arg Cys Gly Asp Ser Val Tyr Ala 
        115                 120                 125             


Ala Glu Lys Ile Ile Gly Ala Gly Lys Pro Trp His Lys Asn Cys Phe 
    130                 135                 140                 


Arg Cys Ala Lys Cys Gly Lys Ser Leu Glu Ser Thr Thr Leu Thr Glu 
145                 150                 155                 160 


Lys Glu Gly Glu Ile Tyr Cys Lys Gly Cys Tyr Ala Lys Asn Phe Gly 
                165                 170                 175     


Pro Lys Gly Phe Gly Tyr Gly Gln Gly Ala Gly Ala Leu Val His Ala 
            180                 185                 190         


Gln 
    


<210>  2662
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSRP3__Homo_sapiens__NP_003467

<400>  2662

Met Pro Asn Trp Gly Gly Gly Ala Lys Cys Gly Ala Cys Glu Lys Thr 
1               5                   10                  15      


Val Tyr His Ala Glu Glu Ile Gln Cys Asn Gly Arg Ser Phe His Lys 
            20                  25                  30          


Thr Cys Phe His Cys Met Ala Cys Arg Lys Ala Leu Asp Ser Thr Thr 
        35                  40                  45              


Val Ala Ala His Glu Ser Glu Ile Tyr Cys Lys Val Cys Tyr Gly Arg 
    50                  55                  60                  


Arg Tyr Gly Pro Lys Gly Ile Gly Tyr Gly Gln Gly Ala Gly Cys Leu 
65                  70                  75                  80  


Ser Thr Asp Thr Gly Glu His Leu Gly Leu Gln Phe Gln Gln Ser Pro 
                85                  90                  95      


Lys Pro Ala Arg Ser Val Thr Thr Ser Asn Pro Ser Lys Phe Thr Ala 
            100                 105                 110         


Lys Phe Gly Glu Ser Glu Lys Cys Pro Arg Cys Gly Lys Ser Val Tyr 
        115                 120                 125             


Ala Ala Glu Lys Val Met Gly Gly Gly Lys Pro Trp His Lys Thr Cys 
    130                 135                 140                 


Phe Arg Cys Ala Ile Cys Gly Lys Ser Leu Glu Ser Thr Asn Val Thr 
145                 150                 155                 160 


Asp Lys Asp Gly Glu Leu Tyr Cys Lys Val Cys Tyr Ala Lys Asn Phe 
                165                 170                 175     


Gly Pro Thr Gly Ile Gly Phe Gly Gly Leu Thr Gln Gln Val Glu Lys 
            180                 185                 190         


Lys Glu 
        


<210>  2663
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST1__Homo_sapiens__NP_001889

<400>  2663

Met Ala Gln Tyr Leu Ser Thr Leu Leu Leu Leu Leu Ala Thr Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Trp Ser Pro Lys Glu Glu Asp Arg Ile Ile Pro Gly 
            20                  25                  30          


Gly Ile Tyr Asn Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Lys Asp Asp Tyr Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Arg Val Leu Arg Ala Arg Gln Gln Thr Val Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asn Arg Arg Ser Leu Val Lys Ser Arg Cys Gln Glu Ser 
    130                 135                 140     


<210>  2664
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST2__Homo_sapiens__NP_001313

<400>  2664

Met Ala Trp Pro Leu Cys Thr Leu Leu Leu Leu Leu Ala Thr Gln Ala 
1               5                   10                  15      


Val Ala Leu Ala Trp Ser Pro Gln Glu Glu Asp Arg Ile Ile Glu Gly 
            20                  25                  30          


Gly Ile Tyr Asp Ala Asp Leu Asn Asp Glu Arg Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Val Ile Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr 
    50                  55                  60                  


Arg Arg Leu Leu Arg Val Leu Arg Ala Arg Glu Gln Ile Val Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Ile Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Gln Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asp Arg Met Ser Leu Val Asn Ser Arg Cys Gln Glu Ala 
    130                 135                 140     


<210>  2665
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST3__Homo_sapiens__NP_001275543

<400>  2665

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  2666
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST4__Homo_sapiens__NP_001890

<400>  2666

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Ser Ser Ser Lys Glu Glu Asn Arg Ile Ile Pro Gly 
            20                  25                  30          


Gly Ile Tyr Asp Ala Asp Leu Asn Asp Glu Trp Val Gln Arg Ala Leu 
        35                  40                  45              


His Phe Ala Ile Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Gln Val Leu Arg Ala Arg Glu Gln Thr Phe Gly Gly 
65                  70                  75                  80  


Val Asn Tyr Phe Phe Asp Val Glu Val Gly Arg Thr Ile Cys Thr Lys 
                85                  90                  95      


Ser Gln Pro Asn Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu 
            100                 105                 110         


Gln Lys Lys Gln Leu Cys Ser Phe Glu Ile Tyr Glu Val Pro Trp Glu 
        115                 120                 125             


Asp Arg Met Ser Leu Val Asn Ser Arg Cys Gln Glu Ala 
    130                 135                 140     


<210>  2667
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST5__Homo_sapiens__NP_001891

<400>  2667

Met Met Trp Pro Met His Thr Pro Leu Leu Leu Leu Thr Ala Leu Met 
1               5                   10                  15      


Val Ala Val Ala Gly Ser Ala Ser Ala Gln Ser Arg Thr Leu Ala Gly 
            20                  25                  30          


Gly Ile His Ala Thr Asp Leu Asn Asp Lys Ser Val Gln Cys Ala Leu 
        35                  40                  45              


Asp Phe Ala Ile Ser Glu Tyr Asn Lys Val Ile Asn Lys Asp Glu Tyr 
    50                  55                  60                  


Tyr Ser Arg Pro Leu Gln Val Met Ala Ala Tyr Gln Gln Ile Val Gly 
65                  70                  75                  80  


Gly Val Asn Tyr Tyr Phe Asn Val Lys Phe Gly Arg Thr Thr Cys Thr 
                85                  90                  95      


Lys Ser Gln Pro Asn Leu Asp Asn Cys Pro Phe Asn Asp Gln Pro Lys 
            100                 105                 110         


Leu Lys Glu Glu Glu Phe Cys Ser Phe Gln Ile Asn Glu Val Pro Trp 
        115                 120                 125             


Glu Asp Lys Ile Ser Ile Leu Asn Tyr Lys Cys Arg Lys Val 
    130                 135                 140         


<210>  2668
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST6__Homo_sapiens__NP_001314

<400>  2668

Met Ala Arg Ser Asn Leu Pro Leu Ala Leu Gly Leu Ala Leu Val Ala 
1               5                   10                  15      


Phe Cys Leu Leu Ala Leu Pro Arg Asp Ala Arg Ala Arg Pro Gln Glu 
            20                  25                  30          


Arg Met Val Gly Glu Leu Arg Asp Leu Ser Pro Asp Asp Pro Gln Val 
        35                  40                  45              


Gln Lys Ala Ala Gln Ala Ala Val Ala Ser Tyr Asn Met Gly Ser Asn 
    50                  55                  60                  


Ser Ile Tyr Tyr Phe Arg Asp Thr His Ile Ile Lys Ala Gln Ser Gln 
65                  70                  75                  80  


Leu Val Ala Gly Ile Lys Tyr Phe Leu Thr Met Glu Met Gly Ser Thr 
                85                  90                  95      


Asp Cys Arg Lys Thr Arg Val Thr Gly Asp His Val Asp Leu Thr Thr 
            100                 105                 110         


Cys Pro Leu Ala Ala Gly Ala Gln Gln Glu Lys Leu Arg Cys Asp Phe 
        115                 120                 125             


Glu Val Leu Val Val Pro Trp Gln Asn Ser Ser Gln Leu Leu Lys His 
    130                 135                 140                 


Asn Cys Val Gln Met 
145                 


<210>  2669
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST7__Homo_sapiens__NP_003641

<400>  2669

Met Arg Ala Ala Gly Thr Leu Leu Ala Phe Cys Cys Leu Val Leu Ser 
1               5                   10                  15      


Thr Thr Gly Gly Pro Ser Pro Asp Thr Cys Ser Gln Asp Leu Asn Ser 
            20                  25                  30          


Arg Val Lys Pro Gly Phe Pro Lys Thr Ile Lys Thr Asn Asp Pro Gly 
        35                  40                  45              


Val Leu Gln Ala Ala Arg Tyr Ser Val Glu Lys Phe Asn Asn Cys Thr 
    50                  55                  60                  


Asn Asp Met Phe Leu Phe Lys Glu Ser Arg Ile Thr Arg Ala Leu Val 
65                  70                  75                  80  


Gln Ile Val Lys Gly Leu Lys Tyr Met Leu Glu Val Glu Ile Gly Arg 
                85                  90                  95      


Thr Thr Cys Lys Lys Asn Gln His Leu Arg Leu Asp Asp Cys Asp Phe 
            100                 105                 110         


Gln Thr Asn His Thr Leu Lys Gln Thr Leu Ser Cys Tyr Ser Glu Val 
        115                 120                 125             


Trp Val Val Pro Trp Leu Gln His Phe Glu Val Pro Val Leu Arg Cys 
    130                 135                 140                 


His 
145 


<210>  2670
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST8__Homo_sapiens__NP_005483

<400>  2670

Met Pro Arg Cys Arg Trp Leu Ser Leu Ile Leu Leu Thr Ile Pro Leu 
1               5                   10                  15      


Ala Leu Val Ala Arg Lys Asp Pro Lys Lys Asn Glu Thr Gly Val Leu 
            20                  25                  30          


Arg Lys Leu Lys Pro Val Asn Ala Ser Asn Ala Asn Val Lys Gln Cys 
        35                  40                  45              


Leu Trp Phe Ala Met Gln Glu Tyr Asn Lys Glu Ser Glu Asp Lys Tyr 
    50                  55                  60                  


Val Phe Leu Val Val Lys Thr Leu Gln Ala Gln Leu Gln Val Thr Asn 
65                  70                  75                  80  


Leu Leu Glu Tyr Leu Ile Asp Val Glu Ile Ala Arg Ser Asp Cys Arg 
                85                  90                  95      


Lys Pro Leu Ser Thr Asn Glu Ile Cys Ala Ile Gln Glu Asn Ser Lys 
            100                 105                 110         


Leu Lys Arg Lys Leu Ser Cys Ser Phe Leu Val Gly Ala Leu Pro Trp 
        115                 120                 125             


Asn Gly Glu Phe Thr Val Met Glu Lys Lys Cys Glu Asp Ala 
    130                 135                 140         


<210>  2671
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST9__Homo_sapiens__NP_001008693

<400>  2671

Met Ser Ser Pro Gln Arg Arg Lys Ala Met Pro Trp Ala Leu Ser Leu 
1               5                   10                  15      


Leu Leu Met Gly Phe Gln Leu Leu Val Thr Tyr Ala Trp Cys Ser Glu 
            20                  25                  30          


Glu Glu Met Gly Gly Asn Asn Lys Ile Val Gln Asp Pro Met Phe Leu 
        35                  40                  45              


Ala Thr Val Glu Phe Ala Leu Asn Thr Phe Asn Val Gln Ser Lys Glu 
    50                  55                  60                  


Glu His Ala Tyr Arg Leu Leu Arg Val Leu Ser Ser Trp Arg Glu Asp 
65                  70                  75                  80  


Ser Met Asp Arg Lys Trp Arg Gly Lys Met Val Phe Ser Met Asn Leu 
                85                  90                  95      


Gln Leu Arg Gln Thr Val Cys Arg Lys Phe Glu Asp Asp Ile Asp Asn 
            100                 105                 110         


Cys Pro Phe Gln Glu Ser Leu Glu Leu Asn Asn Val Arg Gln Gly Ile 
        115                 120                 125             


Ser Phe Pro Gln Val His Ser Cys Gly Cys Cys Met Gly Cys Gly Val 
    130                 135                 140                 


Gly Thr Gly Ala Ala Asp Lys Ala Ile Pro Arg Asp Lys Gly Lys 
145                 150                 155                 


<210>  2672
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CST9L__Homo_sapiens__NP_542177

<400>  2672

Met Leu Gly Leu Pro Trp Lys Gly Gly Leu Ser Trp Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Ser Gln Ile Leu Leu Ile Tyr Ala Trp His Phe His 
            20                  25                  30          


Glu Gln Arg Asp Cys Asp Glu His Asn Val Met Ala Arg Tyr Leu Pro 
        35                  40                  45              


Ala Thr Val Glu Phe Ala Val His Thr Phe Asn Gln Gln Ser Lys Asp 
    50                  55                  60                  


Tyr Tyr Ala Tyr Arg Leu Gly His Ile Leu Asn Ser Trp Lys Glu Gln 
65                  70                  75                  80  


Val Glu Ser Lys Thr Val Phe Ser Met Glu Leu Leu Leu Gly Arg Thr 
                85                  90                  95      


Arg Cys Gly Lys Phe Glu Asp Asp Ile Asp Asn Cys His Phe Gln Glu 
            100                 105                 110         


Ser Thr Glu Leu Asn Asn Thr Phe Thr Cys Phe Phe Thr Ile Ser Thr 
        115                 120                 125             


Arg Pro Trp Met Thr Gln Phe Ser Leu Leu Asn Lys Thr Cys Leu Glu 
    130                 135                 140                 


Gly Phe His 
145         


<210>  2673
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSTA__Homo_sapiens__NP_005204

<400>  2673

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Lys Ser Leu Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  2674
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSTB__Homo_sapiens__NP_000091

<400>  2674

Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 
1               5                   10                  15      


Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 
            20                  25                  30          


Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 
    50                  55                  60                  


Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 
65                  70                  75                  80  


Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 
                85                  90                  95      


Tyr Phe 
        


<210>  2675
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSTF1__Homo_sapiens__NP_001315

<400>  2675

Met Tyr Arg Thr Lys Val Gly Leu Lys Asp Arg Gln Gln Leu Tyr Lys 
1               5                   10                  15      


Leu Ile Ile Ser Gln Leu Leu Tyr Asp Gly Tyr Ile Ser Ile Ala Asn 
            20                  25                  30          


Gly Leu Ile Asn Glu Ile Lys Pro Gln Ser Val Cys Ala Pro Ser Glu 
        35                  40                  45              


Gln Leu Leu His Leu Ile Lys Leu Gly Met Glu Asn Asp Asp Thr Ala 
    50                  55                  60                  


Val Gln Tyr Ala Ile Gly Arg Ser Asp Thr Val Ala Pro Gly Thr Gly 
65                  70                  75                  80  


Ile Asp Leu Glu Phe Asp Ala Asp Val Gln Thr Met Ser Pro Glu Ala 
                85                  90                  95      


Ser Glu Tyr Glu Thr Cys Tyr Val Thr Ser His Lys Gly Pro Cys Arg 
            100                 105                 110         


Val Ala Thr Tyr Ser Arg Asp Gly Gln Leu Ile Ala Thr Gly Ser Ala 
        115                 120                 125             


Asp Ala Ser Ile Lys Ile Leu Asp Thr Glu Arg Met Leu Ala Lys Ser 
    130                 135                 140                 


Ala Met Pro Ile Glu Val Met Met Asn Glu Thr Ala Gln Gln Asn Met 
145                 150                 155                 160 


Glu Asn His Pro Val Ile Arg Thr Leu Tyr Asp His Val Asp Glu Val 
                165                 170                 175     


Thr Cys Leu Ala Phe His Pro Thr Glu Gln Ile Leu Ala Ser Gly Ser 
            180                 185                 190         


Arg Asp Tyr Thr Leu Lys Leu Phe Asp Tyr Ser Lys Pro Ser Ala Lys 
        195                 200                 205             


Arg Ala Phe Lys Tyr Ile Gln Glu Ala Glu Met Leu Arg Ser Ile Ser 
    210                 215                 220                 


Phe His Pro Ser Gly Asp Phe Ile Leu Val Gly Thr Gln His Pro Thr 
225                 230                 235                 240 


Leu Arg Leu Tyr Asp Ile Asn Thr Phe Gln Cys Phe Val Ser Cys Asn 
                245                 250                 255     


Pro Gln Asp Gln His Thr Asp Ala Ile Cys Ser Val Asn Tyr Asn Ser 
            260                 265                 270         


Ser Ala Asn Met Tyr Val Thr Gly Ser Lys Asp Gly Cys Ile Lys Leu 
        275                 280                 285             


Trp Asp Gly Val Ser Asn Arg Cys Ile Thr Thr Phe Glu Lys Ala His 
    290                 295                 300                 


Asp Gly Ala Glu Val Cys Ser Ala Ile Phe Ser Lys Asn Ser Lys Tyr 
305                 310                 315                 320 


Ile Leu Ser Ser Gly Lys Asp Ser Val Ala Lys Leu Trp Glu Ile Ser 
                325                 330                 335     


Thr Gly Arg Thr Leu Val Arg Tyr Thr Gly Ala Gly Leu Ser Gly Arg 
            340                 345                 350         


Gln Val His Arg Thr Gln Ala Val Phe Asn His Thr Glu Asp Tyr Val 
        355                 360                 365             


Leu Leu Pro Asp Glu Arg Thr Ile Ser Leu Cys Cys Trp Asp Ser Arg 
    370                 375                 380                 


Thr Ala Glu Arg Arg Asn Leu Leu Ser Leu Gly His Asn Asn Ile Val 
385                 390                 395                 400 


Arg Cys Ile Val His Ser Pro Thr Asn Pro Gly Phe Met Thr Cys Ser 
                405                 410                 415     


Asp Asp Phe Arg Ala Arg Phe Trp Tyr Arg Arg Ser Thr Thr Asp 
            420                 425                 430     


<210>  2676
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSTF2__Homo_sapiens__NP_001316

<400>  2676

Met Ala Gly Leu Thr Val Arg Asp Pro Ala Val Asp Arg Ser Leu Arg 
1               5                   10                  15      


Ser Val Phe Val Gly Asn Ile Pro Tyr Glu Ala Thr Glu Glu Gln Leu 
            20                  25                  30          


Lys Asp Ile Phe Ser Glu Val Gly Pro Val Val Ser Phe Arg Leu Val 
        35                  40                  45              


Tyr Asp Arg Glu Thr Gly Lys Pro Lys Gly Tyr Gly Phe Cys Glu Tyr 
    50                  55                  60                  


Gln Asp Gln Glu Thr Ala Leu Ser Ala Met Arg Asn Leu Asn Gly Arg 
65                  70                  75                  80  


Glu Phe Ser Gly Arg Ala Leu Arg Val Asp Asn Ala Ala Ser Glu Lys 
                85                  90                  95      


Asn Lys Glu Glu Leu Lys Ser Leu Gly Thr Gly Ala Pro Val Ile Glu 
            100                 105                 110         


Ser Pro Tyr Gly Glu Thr Ile Ser Pro Glu Asp Ala Pro Glu Ser Ile 
        115                 120                 125             


Ser Lys Ala Val Ala Ser Leu Pro Pro Glu Gln Met Phe Glu Leu Met 
    130                 135                 140                 


Lys Gln Met Lys Leu Cys Val Gln Asn Ser Pro Gln Glu Ala Arg Asn 
145                 150                 155                 160 


Met Leu Leu Gln Asn Pro Gln Leu Ala Tyr Ala Leu Leu Gln Ala Gln 
                165                 170                 175     


Val Val Met Arg Ile Val Asp Pro Glu Ile Ala Leu Lys Ile Leu His 
            180                 185                 190         


Arg Gln Thr Asn Ile Pro Thr Leu Ile Ala Gly Asn Pro Gln Pro Val 
        195                 200                 205             


His Gly Ala Gly Pro Gly Ser Gly Ser Asn Val Ser Met Asn Gln Gln 
    210                 215                 220                 


Asn Pro Gln Ala Pro Gln Ala Gln Ser Leu Gly Gly Met His Val Asn 
225                 230                 235                 240 


Gly Ala Pro Pro Leu Met Gln Ala Ser Met Gln Gly Gly Val Pro Ala 
                245                 250                 255     


Pro Gly Gln Met Pro Ala Ala Val Thr Gly Pro Gly Pro Gly Ser Leu 
            260                 265                 270         


Ala Pro Gly Gly Gly Met Gln Ala Gln Val Gly Met Pro Gly Ser Gly 
        275                 280                 285             


Pro Val Ser Met Glu Arg Gly Gln Val Pro Met Gln Asp Pro Arg Ala 
    290                 295                 300                 


Ala Met Gln Arg Gly Ser Leu Pro Ala Asn Val Pro Thr Pro Arg Gly 
305                 310                 315                 320 


Leu Leu Gly Asp Ala Pro Asn Asp Pro Arg Gly Gly Thr Leu Leu Ser 
                325                 330                 335     


Val Thr Gly Glu Val Glu Pro Arg Gly Tyr Leu Gly Pro Pro His Gln 
            340                 345                 350         


Gly Pro Pro Met His His Val Pro Gly His Glu Ser Arg Gly Pro Pro 
        355                 360                 365             


Pro His Glu Leu Arg Gly Gly Pro Leu Pro Glu Pro Arg Pro Leu Met 
    370                 375                 380                 


Ala Glu Pro Arg Gly Pro Met Leu Asp Gln Arg Gly Pro Pro Leu Asp 
385                 390                 395                 400 


Gly Arg Gly Gly Arg Asp Pro Arg Gly Ile Asp Ala Arg Gly Met Glu 
                405                 410                 415     


Ala Arg Ala Met Glu Ala Arg Gly Leu Asp Ala Arg Gly Leu Glu Ala 
            420                 425                 430         


Arg Ala Met Glu Ala Arg Ala Met Glu Ala Arg Ala Met Glu Ala Arg 
        435                 440                 445             


Ala Met Glu Ala Arg Ala Met Glu Val Arg Gly Met Glu Ala Arg Gly 
    450                 455                 460                 


Met Asp Thr Arg Gly Pro Val Pro Gly Pro Arg Gly Pro Ile Pro Ser 
465                 470                 475                 480 


Gly Met Gln Gly Pro Ser Pro Ile Asn Met Gly Ala Val Val Pro Gln 
                485                 490                 495     


Gly Ser Arg Gln Val Pro Val Met Gln Gly Thr Gly Met Gln Gly Ala 
            500                 505                 510         


Ser Ile Gln Gly Gly Ser Gln Pro Gly Gly Phe Ser Pro Gly Gln Asn 
        515                 520                 525             


Gln Val Thr Pro Gln Asp His Glu Lys Ala Ala Leu Ile Met Gln Val 
    530                 535                 540                 


Leu Gln Leu Thr Ala Asp Gln Ile Ala Met Leu Pro Pro Glu Gln Arg 
545                 550                 555                 560 


Gln Ser Ile Leu Ile Leu Lys Glu Gln Ile Gln Lys Ser Thr Gly Ala 
                565                 570                 575     


Pro 
    


<210>  2677
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSTF2T__Homo_sapiens__NP_056050

<400>  2677

Met Ser Ser Leu Ala Val Arg Asp Pro Ala Met Asp Arg Ser Leu Arg 
1               5                   10                  15      


Ser Val Phe Val Gly Asn Ile Pro Tyr Glu Ala Thr Glu Glu Gln Leu 
            20                  25                  30          


Lys Asp Ile Phe Ser Glu Val Gly Ser Val Val Ser Phe Arg Leu Val 
        35                  40                  45              


Tyr Asp Arg Glu Thr Gly Lys Pro Lys Gly Tyr Gly Phe Cys Glu Tyr 
    50                  55                  60                  


Gln Asp Gln Glu Thr Ala Leu Ser Ala Met Arg Asn Leu Asn Gly Arg 
65                  70                  75                  80  


Glu Phe Ser Gly Arg Ala Leu Arg Val Asp Asn Ala Ala Ser Glu Lys 
                85                  90                  95      


Asn Lys Glu Glu Leu Lys Ser Leu Gly Pro Ala Ala Pro Ile Ile Asp 
            100                 105                 110         


Ser Pro Tyr Gly Asp Pro Ile Asp Pro Glu Asp Ala Pro Glu Ser Ile 
        115                 120                 125             


Thr Arg Ala Val Ala Ser Leu Pro Pro Glu Gln Met Phe Glu Leu Met 
    130                 135                 140                 


Lys Gln Met Lys Leu Cys Val Gln Asn Ser His Gln Glu Ala Arg Asn 
145                 150                 155                 160 


Met Leu Leu Gln Asn Pro Gln Leu Ala Tyr Ala Leu Leu Gln Ala Gln 
                165                 170                 175     


Val Val Met Arg Ile Met Asp Pro Glu Ile Ala Leu Lys Ile Leu His 
            180                 185                 190         


Arg Lys Ile His Val Thr Pro Leu Ile Pro Gly Lys Ser Gln Ser Val 
        195                 200                 205             


Ser Val Ser Gly Pro Gly Pro Gly Pro Gly Pro Gly Leu Cys Pro Gly 
    210                 215                 220                 


Pro Asn Val Leu Leu Asn Gln Gln Asn Pro Pro Ala Pro Gln Pro Gln 
225                 230                 235                 240 


His Leu Ala Arg Arg Pro Val Lys Asp Ile Pro Pro Leu Met Gln Thr 
                245                 250                 255     


Pro Ile Gln Gly Gly Ile Pro Ala Pro Gly Pro Ile Pro Ala Ala Val 
            260                 265                 270         


Pro Gly Ala Gly Pro Gly Ser Leu Thr Pro Gly Gly Ala Met Gln Pro 
        275                 280                 285             


Gln Leu Gly Met Pro Gly Val Gly Pro Val Pro Leu Glu Arg Gly Gln 
    290                 295                 300                 


Val Gln Met Ser Asp Pro Arg Ala Pro Ile Pro Arg Gly Pro Val Thr 
305                 310                 315                 320 


Pro Gly Gly Leu Pro Pro Arg Gly Leu Leu Gly Asp Ala Pro Asn Asp 
                325                 330                 335     


Pro Arg Gly Gly Thr Leu Leu Ser Val Thr Gly Glu Val Glu Pro Arg 
            340                 345                 350         


Gly Tyr Leu Gly Pro Pro His Gln Gly Pro Pro Met His His Ala Ser 
        355                 360                 365             


Gly His Asp Thr Arg Gly Pro Ser Ser His Glu Met Arg Gly Gly Pro 
    370                 375                 380                 


Leu Gly Asp Pro Arg Leu Leu Ile Gly Glu Pro Arg Gly Pro Met Ile 
385                 390                 395                 400 


Asp Gln Arg Gly Leu Pro Met Asp Gly Arg Gly Gly Arg Asp Ser Arg 
                405                 410                 415     


Ala Met Glu Thr Arg Ala Met Glu Thr Glu Val Leu Glu Thr Arg Val 
            420                 425                 430         


Met Glu Arg Arg Gly Met Glu Thr Cys Ala Met Glu Thr Arg Gly Met 
        435                 440                 445             


Glu Ala Arg Gly Met Asp Ala Arg Gly Leu Glu Met Arg Gly Pro Val 
    450                 455                 460                 


Pro Ser Ser Arg Gly Pro Met Thr Gly Gly Ile Gln Gly Pro Gly Pro 
465                 470                 475                 480 


Ile Asn Ile Gly Ala Gly Gly Pro Pro Gln Gly Pro Arg Gln Val Pro 
                485                 490                 495     


Gly Ile Ser Gly Val Gly Asn Pro Gly Ala Gly Met Gln Gly Thr Gly 
            500                 505                 510         


Ile Gln Gly Thr Gly Met Gln Gly Ala Gly Ile Gln Gly Gly Gly Met 
        515                 520                 525             


Gln Gly Ala Gly Ile Gln Gly Val Ser Ile Gln Gly Gly Gly Ile Gln 
    530                 535                 540                 


Gly Gly Gly Ile Gln Gly Ala Ser Lys Gln Gly Gly Ser Gln Pro Ser 
545                 550                 555                 560 


Ser Phe Ser Pro Gly Gln Ser Gln Val Thr Pro Gln Asp Gln Glu Lys 
                565                 570                 575     


Ala Ala Leu Ile Met Gln Val Leu Gln Leu Thr Ala Asp Gln Ile Ala 
            580                 585                 590         


Met Leu Pro Pro Glu Gln Arg Gln Ser Ile Leu Ile Leu Lys Glu Gln 
        595                 600                 605             


Ile Gln Lys Ser Thr Gly Ala Ser 
    610                 615     


<210>  2678
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSTL1__Homo_sapiens__NP_612140

<400>  2678

Met Gly Ile Gly Cys Trp Arg Asn Pro Leu Leu Leu Leu Ile Ala Leu 
1               5                   10                  15      


Val Leu Ser Ala Lys Leu Gly His Phe Gln Arg Trp Glu Gly Phe Gln 
            20                  25                  30          


Gln Lys Leu Met Ser Lys Lys Asn Met Asn Ser Thr Leu Asn Phe Phe 
        35                  40                  45              


Ile Gln Ser Tyr Asn Asn Ala Ser Asn Asp Thr Tyr Leu Tyr Arg Val 
    50                  55                  60                  


Gln Arg Leu Ile Arg Ser Gln Met Gln Leu Thr Thr Gly Val Glu Tyr 
65                  70                  75                  80  


Ile Val Thr Val Lys Ile Gly Trp Thr Lys Cys Lys Arg Asn Asp Thr 
                85                  90                  95      


Ser Asn Ser Ser Cys Pro Leu Gln Ser Lys Lys Leu Arg Lys Ser Leu 
            100                 105                 110         


Ile Cys Glu Ser Leu Ile Tyr Thr Met Pro Trp Ile Asn Tyr Phe Gln 
        115                 120                 125             


Leu Trp Asn Asn Ser Cys Leu Glu Ala Glu His Val Gly Arg Asn Leu 
    130                 135                 140                 


Arg 
145 


<210>  2679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT45A1__Homo_sapiens__NP_001017417

<400>  2679

Met Thr Asp Lys Thr Glu Lys Val Ala Val Asp Pro Glu Thr Val Phe 
1               5                   10                  15      


Lys Arg Pro Arg Glu Cys Asp Ser Pro Ser Tyr Gln Lys Arg Gln Arg 
            20                  25                  30          


Met Ala Leu Leu Ala Arg Lys Gln Gly Ala Gly Asp Ser Leu Ile Ala 
        35                  40                  45              


Gly Ser Ala Met Ser Lys Ala Lys Lys Leu Met Thr Gly His Ala Ile 
    50                  55                  60                  


Pro Pro Ser Gln Leu Asp Ser Gln Ile Asp Asp Phe Thr Gly Phe Ser 
65                  70                  75                  80  


Lys Asp Arg Met Met Gln Lys Pro Gly Ser Asn Ala Pro Val Gly Gly 
                85                  90                  95      


Asn Val Thr Ser Ser Phe Ser Gly Asp Asp Leu Glu Cys Arg Glu Thr 
            100                 105                 110         


Ala Ser Ser Pro Lys Ser Gln Arg Glu Ile Asn Ala Asp Ile Lys Arg 
        115                 120                 125             


Lys Leu Val Lys Glu Leu Arg Cys Val Gly Gln Lys Tyr Glu Lys Ile 
    130                 135                 140                 


Phe Glu Met Leu Glu Gly Val Gln Gly Pro Thr Ala Val Arg Lys Arg 
145                 150                 155                 160 


Phe Phe Glu Ser Ile Ile Lys Glu Ala Ala Arg Cys Met Arg Arg Asp 
                165                 170                 175     


Phe Val Lys His Leu Lys Lys Lys Leu Lys Arg Met Ile 
            180                 185                 


<210>  2680
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT55__Homo_sapiens__NP_001026875

<400>  2680

Met Leu Arg Leu Leu Arg Leu Ala Leu Ala Phe Tyr Gly Arg Thr Ala 
1               5                   10                  15      


Asp Pro Ala Glu Arg Gln Gly Pro Gln Gln Gln Gly Leu Pro Gln Gly 
            20                  25                  30          


Asp Thr Gln Leu Thr Thr Val Gln Gly Val Val Thr Ser Phe Cys Gly 
        35                  40                  45              


Asp Tyr Gly Met Ile Asp Glu Ser Ile Tyr Phe Ser Ser Asp Val Val 
    50                  55                  60                  


Thr Gly Asn Val Pro Leu Lys Val Gly Gln Lys Val Asn Val Val Val 
65                  70                  75                  80  


Glu Glu Asp Lys Pro His Tyr Gly Leu Arg Ala Ile Lys Val Asp Val 
                85                  90                  95      


Val Pro Arg His Leu Tyr Gly Ala Gly Pro Ser Asp Ser Gly Thr Arg 
            100                 105                 110         


Val Leu Ile Gly Cys Val Thr Ser Ile Asn Glu Asp Asn Ile Tyr Ile 
        115                 120                 125             


Ser Asn Ser Ile Tyr Phe Ser Ile Ala Ile Val Ser Glu Asp Phe Val 
    130                 135                 140                 


Pro Tyr Lys Gly Asp Leu Leu Glu Val Glu Tyr Ser Thr Glu Pro Gly 
145                 150                 155                 160 


Ile Ser Asn Ile Lys Ala Thr Ser Val Lys Pro Ile Arg Cys Ile His 
                165                 170                 175     


Thr Glu Glu Val Cys Ile Thr Ser Val His Gly Arg Asn Gly Val Ile 
            180                 185                 190         


Asp Tyr Thr Ile Phe Phe Thr Leu Asp Ser Val Lys Leu Pro Asp Gly 
        195                 200                 205             


Tyr Val Pro Gln Val Asp Asp Ile Val Asn Val Val Met Val Glu Ser 
    210                 215                 220                 


Ile Gln Phe Cys Phe Ile Trp Arg Ala Ile Ser Ile Thr Pro Val His 
225                 230                 235                 240 


Lys Ser Ser Ser Gly Phe Gln Asp Asp Gly Gly Leu Gly Arg Pro Lys 
                245                 250                 255     


Arg Glu Arg Arg Ser Gln Ser Ile 
            260                 


<210>  2681
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT83__Homo_sapiens__NP_001017978

<400>  2681

Met Asn Phe Tyr Leu Leu Leu Ala Ser Ser Ile Leu Cys Ala Leu Ile 
1               5                   10                  15      


Val Phe Trp Lys Tyr Arg Arg Phe Gln Arg Asn Thr Gly Glu Met Ser 
            20                  25                  30          


Ser Asn Ser Thr Ala Leu Ala Leu Val Arg Pro Ser Ser Ser Gly Leu 
        35                  40                  45              


Ile Asn Ser Asn Thr Asp Asn Asn Leu Ala Val Tyr Asp Leu Ser Arg 
    50                  55                  60                  


Asp Ile Leu Asn Asn Phe Pro His Ser Ile Ala Arg Gln Lys Arg Ile 
65                  70                  75                  80  


Leu Val Asn Leu Ser Met Val Glu Asn Lys Leu Val Glu Leu Glu His 
                85                  90                  95      


Thr Leu Leu Ser Lys Gly Phe Arg Gly Ala Ser Pro His Arg Lys Ser 
            100                 105                 110         


Thr 
    


<210>  2682
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTAG1A__Homo_sapiens__NP_640343

<400>  2682

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  2683
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTAG2__Homo_sapiens__NP_066274

<400>  2683

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Glu Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Met Ser Val Arg Asp Gln Asp Arg Glu Gly 
    130                 135                 140                 


Ala Gly Arg Met Arg Val Val Gly Trp Gly Leu Gly Ser Ala Ser Pro 
145                 150                 155                 160 


Glu Gly Gln Lys Ala Arg Asp Leu Arg Thr Pro Lys His Lys Val Ser 
                165                 170                 175     


Glu Gln Arg Pro Gly Thr Pro Gly Pro Pro Pro Pro Glu Gly Ala Gln 
            180                 185                 190         


Gly Asp Gly Cys Arg Gly Val Ala Phe Asn Val Met Phe Ser Ala Pro 
        195                 200                 205             


His Ile 
    210 


<210>  2684
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTAGE1__Homo_sapiens__NP_758441

<400>  2684

Met Arg Pro Asp Ser His Pro Tyr Gly Phe Pro Trp Glu Leu Val Ile 
1               5                   10                  15      


Arg Ala Ala Val Ala Gly Phe Phe Ala Val Leu Phe Leu Trp Arg Ser 
            20                  25                  30          


Phe Arg Ser Val Thr Ser Arg Leu Tyr Val Arg Arg Glu Lys Lys Phe 
        35                  40                  45              


Ala Val Ala Leu Ser Gly Leu Ile Glu Glu Lys Cys Lys Leu Leu Glu 
    50                  55                  60                  


Lys Phe Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser 
65                  70                  75                  80  


Ser Leu Lys Asn Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser 
                85                  90                  95      


Leu Glu Ala Thr Cys Glu Lys Leu Asn Arg Phe Asn Ser Glu Leu Val 
            100                 105                 110         


His Glu Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu Lys Ser Lys 
        115                 120                 125             


His Ser Glu Gln Asn Glu Leu Met Ala Asp Ile Ser Lys Arg Ile Gln 
    130                 135                 140                 


Ser Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val Ala Glu Ala 
145                 150                 155                 160 


Lys Met Thr Phe Lys Arg Phe Gln Ala Asn Glu Glu Arg Leu Glu Ile 
                165                 170                 175     


Glu Ile Gln Asp Ala Trp Lys Glu Asn Ser Glu Leu Gln Glu Ser Gln 
            180                 185                 190         


Lys Gln Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln Val Ser Glu 
        195                 200                 205             


Leu Ile Lys Gln Lys Arg Thr Phe Glu Asp Ser Lys Val His Ala Glu 
    210                 215                 220                 


Gln Val Leu Asn Asp Lys Glu Asn His Ile Lys Thr Leu Thr Glu Arg 
225                 230                 235                 240 


Leu Leu Lys Met Lys Asp Gly Val Ala Met Leu Glu Glu Asp Val Thr 
                245                 250                 255     


Asp Asp Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser Glu Asp Gly 
            260                 265                 270         


Ala Tyr Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His 
        275                 280                 285             


Ala Ala Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly Glu Arg Asn 
    290                 295                 300                 


Gln Ile Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu 
305                 310                 315                 320 


Thr Glu His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser Leu Gln Ser 
                325                 330                 335     


Glu Asn Thr His Phe Glu Ser Glu Asn Gln Lys Leu Gln Gln Lys Leu 
            340                 345                 350         


Lys Val Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys Leu Tyr Arg 
        355                 360                 365             


Lys Leu Ile Val Glu Glu Lys Cys Arg Leu Glu Lys Glu Glu Lys Leu 
    370                 375                 380                 


Ser Lys Val Asp Glu Met Ile Ser His Ala Thr Glu Glu Leu Glu Thr 
385                 390                 395                 400 


Tyr Arg Lys Arg Ala Lys Asp Leu Lys Glu Phe Glu Lys Thr Ile His 
                405                 410                 415     


Phe Tyr Gln Lys Lys Ile Ile Leu His Glu Lys Lys Ala His Asp Asn 
            420                 425                 430         


Trp Ser Ala Ala Trp Thr Ala Glu Arg Asn Leu Asn Asp Leu Arg Lys 
        435                 440                 445             


Glu Asn Ala His Asn Arg Gln Lys Leu Thr Glu Ile Glu Phe Lys Ile 
    450                 455                 460                 


Lys Leu Leu Glu Lys Asp Pro Tyr Gly Leu Asp Val Pro Asn Thr Ala 
465                 470                 475                 480 


Phe Gly Arg Gln His Ser Pro Tyr Gly Pro Ser Pro Leu Gly Trp Pro 
                485                 490                 495     


Ser Ser Glu Thr Arg Ala Ser Leu Tyr Pro Pro Thr Leu Leu Glu Gly 
            500                 505                 510         


Pro Leu Arg Leu Ser Pro Leu Leu Pro Arg Gly Gly Gly Arg Gly Ser 
        515                 520                 525             


Arg Gly Pro Gly Asn Pro Pro Asp His Gln Ile Thr Lys Glu Arg Gly 
    530                 535                 540                 


Glu Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg Ala Pro Ser Asp 
545                 550                 555                 560 


Ala Gly Pro Leu Ala Pro Pro Trp Glu Gln Asp Tyr Arg Met Met Phe 
                565                 570                 575     


Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu Pro Pro Gln Arg 
            580                 585                 590         


Gln Asp Arg Phe Tyr Ser Asn Cys Ala Arg Leu Ser Gly Pro Ala Glu 
        595                 600                 605             


Leu Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met Asp Gly Ser Met 
    610                 615                 620                 


Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys Asp Asn Leu Gly 
625                 630                 635                 640 


Asn Leu Lys Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala Thr 
                645                 650                 655     


Gly Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile Arg Gly Leu Leu 
            660                 665                 670         


Phe Pro Val Asp Thr Arg Gly Pro Phe Ile Arg Arg Gly Pro Pro Phe 
        675                 680                 685             


Pro Pro Pro Pro Pro Gly Thr Val Phe Gly Ala Ser Pro Asp Tyr Phe 
    690                 695                 700                 


Ser Pro Arg Asp Val Pro Gly Pro Pro Arg Ala Pro Phe Ala Met Arg 
705                 710                 715                 720 


Asn Val Tyr Leu Pro Arg Gly Phe Leu Pro Tyr Arg Pro Pro Arg Pro 
                725                 730                 735     


Ala Phe Phe Pro Pro Ala Pro Thr Phe 
            740                 745 


<210>  2685
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTAGE5__Homo_sapiens__NP_001234918

<400>  2685

Met Glu Glu Pro Gly Val Thr Pro Gln Pro Tyr Leu Gly Leu Leu Leu 
1               5                   10                  15      


Glu Glu Leu Arg Arg Val Val Ala Ala Leu Pro Glu Gly Met Arg Pro 
            20                  25                  30          


Asp Ser Asn Leu Tyr Gly Phe Pro Trp Glu Leu Val Ile Cys Ala Ala 
        35                  40                  45              


Val Val Gly Phe Phe Ala Val Leu Phe Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Lys Lys Leu Ala Leu 
65                  70                  75                  80  


Met Leu Ser Gly Leu Ile Glu Glu Lys Ser Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Val Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Lys Asp Ala Ser Phe Glu Lys Glu Ala Thr Glu Ala Gln Ser Leu Glu 
        115                 120                 125             


Val Glu Asn Gln Met Ala Thr Cys Glu Lys Leu Asn Arg Ser Asn Ser 
    130                 135                 140                 


Glu Leu Glu Asp Glu Ile Leu Cys Leu Glu Lys Glu Leu Lys Glu Glu 
145                 150                 155                 160 


Lys Ser Lys His Ser Glu Gln Asp Glu Leu Met Ala Asp Ile Ser Lys 
                165                 170                 175     


Arg Ile Gln Ser Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Val 
            180                 185                 190         


Ala Glu Ala Lys Met Thr Phe Lys Ile Phe Gln Met Asn Glu Glu Arg 
        195                 200                 205             


Leu Lys Ile Ala Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln 
    210                 215                 220                 


Glu Ser Gln Lys Gln Leu Leu Gln Glu Ala Glu Val Trp Lys Glu Gln 
225                 230                 235                 240 


Val Ser Glu Leu Asn Lys Gln Lys Val Thr Phe Glu Asp Ser Lys Val 
                245                 250                 255     


His Ala Glu Gln Val Leu Asn Asp Lys Glu Ser His Ile Lys Thr Leu 
            260                 265                 270         


Thr Glu Arg Leu Leu Lys Met Lys Asp Trp Ala Ala Met Leu Gly Glu 
        275                 280                 285             


Asp Ile Thr Asp Asp Asp Asn Leu Glu Leu Glu Met Asn Ser Glu Ser 
    290                 295                 300                 


Glu Asn Gly Ala Tyr Leu Asp Asn Pro Pro Lys Gly Ala Leu Lys Lys 
305                 310                 315                 320 


Leu Ile His Ala Ala Lys Leu Asn Ala Ser Leu Lys Thr Leu Glu Gly 
                325                 330                 335     


Glu Arg Asn Gln Ile Tyr Ile Gln Leu Ser Glu Val Asp Lys Thr Lys 
            340                 345                 350         


Glu Glu Leu Thr Glu His Ile Lys Asn Leu Gln Thr Glu Gln Ala Ser 
        355                 360                 365             


Leu Gln Ser Glu Asn Thr His Phe Glu Asn Glu Asn Gln Lys Leu Gln 
    370                 375                 380                 


Gln Lys Leu Lys Val Met Thr Glu Leu Tyr Gln Glu Asn Glu Met Lys 
385                 390                 395                 400 


Leu His Arg Lys Leu Thr Val Glu Glu Asn Tyr Arg Leu Glu Lys Glu 
                405                 410                 415     


Glu Lys Leu Ser Lys Val Asp Glu Lys Ile Ser His Ala Thr Glu Glu 
            420                 425                 430         


Leu Glu Thr Tyr Arg Lys Arg Ala Lys Asp Leu Glu Glu Glu Leu Glu 
        435                 440                 445             


Arg Thr Ile His Ser Tyr Gln Gly Gln Ile Ile Ser His Glu Lys Lys 
    450                 455                 460                 


Ala His Asp Asn Trp Leu Ala Ala Arg Asn Ala Glu Arg Asn Leu Asn 
465                 470                 475                 480 


Asp Leu Arg Lys Glu Asn Ala His Asn Arg Gln Lys Leu Thr Glu Thr 
                485                 490                 495     


Glu Leu Lys Phe Glu Leu Leu Glu Lys Asp Pro Tyr Ala Leu Asp Val 
            500                 505                 510         


Pro Asn Thr Ala Phe Gly Arg Glu His Ser Pro Tyr Gly Pro Ser Pro 
        515                 520                 525             


Leu Gly Trp Pro Ser Ser Glu Thr Arg Ala Phe Leu Ser Pro Pro Thr 
    530                 535                 540                 


Leu Leu Glu Gly Pro Leu Arg Leu Ser Pro Leu Leu Pro Gly Gly Gly 
545                 550                 555                 560 


Gly Arg Gly Ser Arg Gly Pro Gly Asn Pro Leu Asp His Gln Ile Thr 
                565                 570                 575     


Asn Glu Arg Gly Glu Ser Ser Cys Asp Arg Leu Thr Asp Pro His Arg 
            580                 585                 590         


Ala Pro Ser Asp Thr Gly Ser Leu Ser Pro Pro Trp Asp Gln Asp Arg 
        595                 600                 605             


Arg Met Met Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Ala Leu 
    610                 615                 620                 


Pro Pro Gln Arg Gln Asp Arg Phe Cys Ser Asn Ser Gly Arg Leu Ser 
625                 630                 635                 640 


Gly Pro Ala Glu Leu Arg Ser Phe Asn Met Pro Ser Leu Asp Lys Met 
                645                 650                 655     


Asp Gly Ser Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Thr Lys 
            660                 665                 670         


Asp Asp Leu Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu 
        675                 680                 685             


Asn Glu Ala Thr Gly Pro Gly Phe Val Pro Pro Pro Leu Ala Pro Ile 
    690                 695                 700                 


Arg Gly Pro Leu Phe Pro Val Asp Ala Arg Gly Pro Phe Leu Arg Arg 
705                 710                 715                 720 


Gly Pro Pro Phe Pro Pro Pro Pro Pro Gly Ala Met Phe Gly Ala Ser 
                725                 730                 735     


Arg Asp Tyr Phe Pro Pro Gly Asp Phe Pro Gly Pro Pro Pro Ala Pro 
            740                 745                 750         


Phe Ala Met Arg Asn Val Tyr Pro Pro Arg Gly Phe Pro Pro Tyr Leu 
        755                 760                 765             


Pro Pro Arg Pro Gly Phe Phe Pro Pro Pro Pro His Ser Glu Gly Arg 
    770                 775                 780                 


Ser Glu Phe Pro Ser Gly Leu Ile Pro Pro Ser Asn Glu Pro Ala Thr 
785                 790                 795                 800 


Glu His Pro Glu Pro Gln Gln Glu Thr 
                805                 


<210>  2686
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTBP1__Homo_sapiens__NP_001012632

<400>  2686

Met Ser Gly Val Arg Pro Pro Ile Met Asn Gly Pro Leu His Pro Arg 
1               5                   10                  15      


Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro 
            20                  25                  30          


Ile Leu Lys Asp Val Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr 
        35                  40                  45              


Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Leu Met 
    50                  55                  60                  


Tyr His Thr Ile Thr Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys Ala 
65                  70                  75                  80  


Leu Arg Ile Ile Val Arg Ile Gly Ser Gly Phe Asp Asn Ile Asp Ile 
                85                  90                  95      


Lys Ser Ala Gly Asp Leu Gly Ile Ala Val Cys Asn Val Pro Ala Ala 
            100                 105                 110         


Ser Val Glu Glu Thr Ala Asp Ser Thr Leu Cys His Ile Leu Asn Leu 
        115                 120                 125             


Tyr Arg Arg Ala Thr Trp Leu His Gln Ala Leu Arg Glu Gly Thr Arg 
    130                 135                 140                 


Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg 
145                 150                 155                 160 


Ile Arg Gly Glu Thr Leu Gly Ile Ile Gly Leu Gly Arg Val Gly Gln 
                165                 170                 175     


Ala Val Ala Leu Arg Ala Lys Ala Phe Gly Phe Asn Val Leu Phe Tyr 
            180                 185                 190         


Asp Pro Tyr Leu Ser Asp Gly Val Glu Arg Ala Leu Gly Leu Gln Arg 
        195                 200                 205             


Val Ser Thr Leu Gln Asp Leu Leu Phe His Ser Asp Cys Val Thr Leu 
    210                 215                 220                 


His Cys Gly Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe Thr 
225                 230                 235                 240 


Val Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Thr Ala Arg Gly 
                245                 250                 255     


Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg 
            260                 265                 270         


Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe 
        275                 280                 285             


Ser Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His 
    290                 295                 300                 


Ala Ala Trp Tyr Ser Glu Gln Ala Ser Ile Glu Met Arg Glu Glu Ala 
305                 310                 315                 320 


Ala Arg Glu Ile Arg Arg Ala Ile Thr Gly Arg Ile Pro Asp Ser Leu 
                325                 330                 335     


Lys Asn Cys Val Asn Lys Asp His Leu Thr Ala Ala Thr His Trp Ala 
            340                 345                 350         


Ser Met Asp Pro Ala Val Val His Pro Glu Leu Asn Gly Ala Ala Tyr 
        355                 360                 365             


Arg Tyr Pro Pro Gly Val Val Gly Val Ala Pro Thr Gly Ile Pro Ala 
    370                 375                 380                 


Ala Val Glu Gly Ile Val Pro Ser Ala Met Ser Leu Ser His Gly Leu 
385                 390                 395                 400 


Pro Pro Val Ala His Pro Pro His Ala Pro Ser Pro Gly Gln Thr Val 
                405                 410                 415     


Lys Pro Glu Ala Asp Arg Asp His Ala Ser Asp Gln Leu 
            420                 425                 


<210>  2687
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTBP2__Homo_sapiens__NP_001277143

<400>  2687

Met Ala Leu Val Asp Lys His Lys Val Lys Arg Gln Arg Leu Asp Arg 
1               5                   10                  15      


Ile Cys Glu Gly Ile Arg Pro Gln Ile Met Asn Gly Pro Leu His Pro 
            20                  25                  30          


Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Thr Val Glu Met 
        35                  40                  45              


Pro Ile Leu Lys Asp Leu Ala Thr Val Ala Phe Cys Asp Ala Gln Ser 
    50                  55                  60                  


Thr Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Met 
65                  70                  75                  80  


Met Tyr His Thr Ile Thr Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys 
                85                  90                  95      


Ala Leu Arg Val Ile Val Arg Ile Gly Ser Gly Tyr Asp Asn Val Asp 
            100                 105                 110         


Ile Lys Ala Ala Gly Glu Leu Gly Ile Ala Val Cys Asn Ile Pro Ser 
        115                 120                 125             


Ala Ala Val Glu Glu Thr Ala Asp Ser Thr Ile Cys His Ile Leu Asn 
    130                 135                 140                 


Leu Tyr Arg Arg Asn Thr Trp Leu Tyr Gln Ala Leu Arg Glu Gly Thr 
145                 150                 155                 160 


Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala 
                165                 170                 175     


Arg Ile Arg Gly Glu Thr Leu Gly Leu Ile Gly Phe Gly Arg Thr Gly 
            180                 185                 190         


Gln Ala Val Ala Val Arg Ala Lys Ala Phe Gly Phe Ser Val Ile Phe 
        195                 200                 205             


Tyr Asp Pro Tyr Leu Gln Asp Gly Ile Glu Arg Ser Leu Gly Val Gln 
    210                 215                 220                 


Arg Val Tyr Thr Leu Gln Asp Leu Leu Tyr Gln Ser Asp Cys Val Ser 
225                 230                 235                 240 


Leu His Cys Asn Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe 
                245                 250                 255     


Thr Ile Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Ala Ala Arg 
            260                 265                 270         


Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly 
        275                 280                 285             


Arg Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser 
    290                 295                 300                 


Phe Ala Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro 
305                 310                 315                 320 


His Thr Ala Trp Tyr Ser Glu Gln Ala Ser Leu Glu Met Arg Glu Ala 
                325                 330                 335     


Ala Ala Thr Glu Ile Arg Arg Ala Ile Thr Gly Arg Ile Pro Glu Ser 
            340                 345                 350         


Leu Arg Asn Cys Val Asn Lys Glu Phe Phe Val Thr Ser Ala Pro Trp 
        355                 360                 365             


Ser Val Ile Asp Gln Gln Ala Ile His Pro Glu Leu Asn Gly Ala Thr 
    370                 375                 380                 


Tyr Arg Tyr Pro Pro Gly Ile Val Gly Val Ala Pro Gly Gly Leu Pro 
385                 390                 395                 400 


Ala Ala Met Glu Gly Ile Ile Pro Gly Gly Ile Pro Val Thr His Asn 
                405                 410                 415     


Leu Pro Thr Val Ala His Pro Ser Gln Ala Pro Ser Pro Asn Gln Pro 
            420                 425                 430         


Thr Lys His Gly Asp Asn Arg Glu His Pro Asn Glu Gln 
        435                 440                 445 


<210>  2688
<211>  1217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTC1__Homo_sapiens__NP_079375

<400>  2688

Met Ala Ala Gly Arg Ala Gln Val Pro Ser Ser Glu Gln Ala Trp Leu 
1               5                   10                  15      


Glu Asp Ala Gln Val Phe Ile Gln Lys Thr Leu Cys Pro Ala Val Lys 
            20                  25                  30          


Glu Pro Asn Val Gln Leu Thr Pro Leu Val Ile Asp Cys Val Lys Thr 
        35                  40                  45              


Val Trp Leu Ser Gln Gly Arg Asn Gln Gly Ser Thr Leu Pro Leu Ser 
    50                  55                  60                  


Tyr Ser Phe Val Ser Val Gln Asp Leu Lys Thr His Gln Arg Leu Pro 
65                  70                  75                  80  


Cys Cys Ser His Leu Ser Trp Ser Ser Ser Ala Tyr Gln Ala Trp Ala 
                85                  90                  95      


Gln Glu Ala Gly Pro Asn Gly Asn Pro Leu Pro Arg Glu Gln Leu Leu 
            100                 105                 110         


Leu Leu Gly Thr Leu Thr Asp Leu Ser Ala Asp Leu Glu Gln Glu Cys 
        115                 120                 125             


Arg Asn Gly Ser Leu Tyr Val Arg Asp Asn Thr Gly Val Leu Ser Cys 
    130                 135                 140                 


Glu Leu Ile Asp Leu Asp Leu Ser Trp Leu Gly His Leu Phe Leu Phe 
145                 150                 155                 160 


Pro Arg Trp Ser Tyr Leu Pro Pro Ala Arg Trp Asn Ser Ser Gly Glu 
                165                 170                 175     


Gly His Leu Glu Leu Trp Asp Ala Pro Val Pro Val Phe Pro Leu Thr 
            180                 185                 190         


Ile Ser Pro Gly Pro Val Thr Pro Ile Pro Val Leu Tyr Pro Glu Ser 
        195                 200                 205             


Ala Ser Cys Leu Leu Arg Leu Arg Asn Lys Leu Arg Gly Val Gln Arg 
    210                 215                 220                 


Asn Leu Ala Gly Ser Leu Val Arg Leu Ser Ala Leu Val Lys Ser Lys 
225                 230                 235                 240 


Gln Lys Ala Tyr Phe Ile Leu Ser Leu Gly Arg Ser His Pro Ala Val 
                245                 250                 255     


Thr His Val Ser Ile Ile Val Gln Val Pro Ala Gln Leu Val Trp His 
            260                 265                 270         


Arg Ala Leu Arg Pro Gly Thr Ala Tyr Val Leu Thr Glu Leu Arg Val 
        275                 280                 285             


Ser Lys Ile Arg Gly Gln Arg Gln His Val Trp Met Thr Ser Gln Ser 
    290                 295                 300                 


Ser Arg Leu Leu Leu Leu Lys Pro Glu Cys Val Gln Glu Leu Glu Leu 
305                 310                 315                 320 


Glu Leu Glu Gly Pro Leu Leu Glu Ala Asp Pro Lys Pro Leu Pro Met 
                325                 330                 335     


Pro Ser Asn Ser Glu Asp Lys Lys Asp Pro Glu Ser Leu Val Arg Tyr 
            340                 345                 350         


Ser Arg Leu Leu Ser Tyr Ser Gly Ala Val Thr Gly Val Leu Asn Glu 
        355                 360                 365             


Pro Ala Gly Leu Tyr Glu Leu Asp Gly Gln Leu Gly Leu Cys Leu Ala 
    370                 375                 380                 


Tyr Gln Gln Phe Arg Gly Leu Arg Arg Val Met Arg Pro Gly Val Cys 
385                 390                 395                 400 


Leu Gln Leu Gln Asp Val His Leu Leu Gln Ser Val Gly Gly Gly Thr 
                405                 410                 415     


Arg Arg Pro Val Leu Ala Pro Cys Leu Arg Gly Ala Val Leu Leu Gln 
            420                 425                 430         


Ser Phe Ser Arg Gln Lys Pro Gly Ala His Ser Ser Arg Gln Ala Tyr 
        435                 440                 445             


Gly Ala Ser Leu Tyr Glu Gln Leu Val Trp Glu Arg Gln Leu Gly Leu 
    450                 455                 460                 


Pro Leu Tyr Leu Trp Ala Thr Lys Ala Leu Glu Glu Leu Ala Cys Lys 
465                 470                 475                 480 


Leu Cys Pro His Val Leu Arg His His Gln Phe Leu Gln His Ser Ser 
                485                 490                 495     


Pro Gly Ser Pro Ser Leu Gly Leu Gln Leu Leu Ala Pro Thr Leu Asp 
            500                 505                 510         


Leu Leu Ala Pro Pro Gly Ser Pro Val Arg Asn Ala His Asn Glu Ile 
        515                 520                 525             


Leu Glu Glu Pro His His Cys Pro Leu Gln Lys Tyr Thr Arg Leu Gln 
    530                 535                 540                 


Thr Pro Ser Ser Phe Pro Thr Leu Ala Thr Leu Lys Glu Glu Gly Gln 
545                 550                 555                 560 


Arg Lys Ala Trp Ala Ser Phe Asp Pro Lys Ala Leu Leu Pro Leu Pro 
                565                 570                 575     


Glu Ala Ser Tyr Leu Pro Ser Cys Gln Leu Asn Arg Arg Leu Ala Trp 
            580                 585                 590         


Ser Trp Leu Cys Leu Leu Pro Ser Ala Phe Cys Pro Ala Gln Val Leu 
        595                 600                 605             


Leu Gly Val Leu Val Ala Ser Ser His Lys Gly Cys Leu Gln Leu Arg 
    610                 615                 620                 


Asp Gln Ser Gly Ser Leu Pro Cys Leu Leu Leu Ala Lys His Ser Gln 
625                 630                 635                 640 


Pro Leu Ser Asp Pro Arg Leu Ile Gly Cys Leu Val Arg Ala Glu Arg 
                645                 650                 655     


Phe Gln Leu Ile Val Glu Arg Asp Val Arg Ser Ser Phe Pro Ser Trp 
            660                 665                 670         


Lys Glu Leu Ser Met Pro Gly Phe Ile Gln Lys Gln Gln Ala Arg Val 
        675                 680                 685             


Tyr Val Gln Phe Phe Leu Ala Asp Ala Leu Ile Leu Pro Val Pro Arg 
    690                 695                 700                 


Pro Cys Leu His Ser Ala Thr Pro Ser Thr Pro Gln Thr Asp Pro Thr 
705                 710                 715                 720 


Gly Pro Glu Gly Pro His Leu Gly Gln Ser Arg Leu Phe Leu Leu Cys 
                725                 730                 735     


His Lys Glu Ala Leu Met Lys Arg Asn Phe Cys Val Pro Pro Gly Ala 
            740                 745                 750         


Ser Pro Glu Val Pro Lys Pro Ala Leu Ser Phe Tyr Val Leu Gly Ser 
        755                 760                 765             


Trp Leu Gly Gly Thr Gln Arg Lys Glu Gly Thr Gly Trp Gly Leu Pro 
    770                 775                 780                 


Glu Pro Gln Gly Asn Asp Asp Asn Asp Gln Lys Val His Leu Ile Phe 
785                 790                 795                 800 


Phe Gly Ser Ser Val Arg Trp Phe Glu Phe Leu His Pro Gly Gln Val 
                805                 810                 815     


Tyr Arg Leu Ile Ala Pro Gly Pro Ala Thr Pro Met Leu Phe Glu Lys 
            820                 825                 830         


Asp Gly Ser Ser Cys Ile Ser Arg Arg Pro Leu Glu Leu Ala Gly Cys 
        835                 840                 845             


Ala Ser Cys Leu Thr Val Gln Asp Asn Trp Thr Leu Glu Leu Glu Ser 
    850                 855                 860                 


Ser Gln Asp Ile Gln Asp Val Leu Asp Ala Asn Lys Ser Leu Pro Glu 
865                 870                 875                 880 


Ser Ser Leu Thr Asp Leu Leu Ser Asp Asn Phe Thr Asp Ser Leu Val 
                885                 890                 895     


Ser Phe Ser Ala Glu Ile Leu Ser Arg Thr Leu Cys Glu Pro Leu Val 
            900                 905                 910         


Ala Ser Leu Trp Met Lys Leu Gly Asn Thr Gly Ala Met Arg Arg Cys 
        915                 920                 925             


Val Lys Leu Thr Val Ala Leu Glu Thr Ala Glu Cys Glu Phe Pro Pro 
    930                 935                 940                 


His Leu Asp Val Tyr Ile Glu Asp Pro His Leu Pro Pro Ser Leu Gly 
945                 950                 955                 960 


Leu Leu Pro Gly Ala Arg Val His Phe Ser Gln Leu Glu Lys Arg Val 
                965                 970                 975     


Ser Arg Ser His Asn Val Tyr Cys Cys Phe Arg Ser Ser Thr Tyr Val 
            980                 985                 990         


Gln Val Leu Ser Phe Pro Pro Glu  Thr Thr Ile Ser Ile  Pro Leu Pro 
        995                 1000                 1005             


His Ile  Tyr Leu Ala Glu Leu  Leu Gln Gly Gly Gln  Ser Pro Phe 
    1010                 1015                 1020             


Gln Ala  Thr Ala Ser Cys His  Ile Val Ser Val Phe  Ser Leu Gln 
    1025                 1030                 1035             


Leu Phe  Trp Val Cys Ala Tyr  Cys Thr Ser Ile Cys  Arg Gln Gly 
    1040                 1045                 1050             


Lys Cys  Thr Arg Leu Gly Ser  Thr Cys Pro Thr Gln  Thr Ala Ile 
    1055                 1060                 1065             


Ser Gln  Ala Ile Ile Arg Leu  Leu Val Glu Asp Gly  Thr Ala Glu 
    1070                 1075                 1080             


Ala Val  Val Thr Cys Arg Asn  His His Val Ala Ala  Ala Leu Gly 
    1085                 1090                 1095             


Leu Cys  Pro Arg Glu Trp Ala  Ser Leu Leu Asp Phe  Val Gln Val 
    1100                 1105                 1110             


Pro Gly  Arg Val Val Leu Gln  Phe Ala Gly Pro Gly  Ala Gln Leu 
    1115                 1120                 1125             


Glu Ser  Ser Ala Arg Val Asp  Glu Pro Met Thr Met  Phe Leu Trp 
    1130                 1135                 1140             


Thr Leu  Cys Thr Ser Pro Ser  Val Leu Arg Pro Ile  Val Leu Ser 
    1145                 1150                 1155             


Phe Glu  Leu Glu Arg Lys Pro  Ser Lys Ile Val Pro  Leu Glu Pro 
    1160                 1165                 1170             


Pro Arg  Leu Gln Arg Phe Gln  Cys Gly Glu Leu Pro  Phe Leu Thr 
    1175                 1180                 1185             


His Val  Asn Pro Arg Leu Arg  Leu Ser Cys Leu Ser  Ile Arg Glu 
    1190                 1195                 1200             


Ser Glu  Tyr Ser Ser Ser Leu  Gly Ile Leu Ala Ser  Ser Cys 
    1205                 1210                 1215         


<210>  2689
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTCF__Homo_sapiens__NP_001177951

<400>  2689

Met Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys 
1               5                   10                  15      


His Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Asp Tyr Ala Ser 
            20                  25                  30          


Val Glu Val Ser Lys Leu Lys Arg His Ile Arg Ser His Thr Gly Glu 
        35                  40                  45              


Arg Pro Phe Gln Cys Ser Leu Cys Ser Tyr Ala Ser Arg Asp Thr Tyr 
    50                  55                  60                  


Lys Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu 
65                  70                  75                  80  


Cys Tyr Ile Cys His Ala Arg Phe Thr Gln Ser Gly Thr Met Lys Met 
                85                  90                  95      


His Ile Leu Gln Lys His Thr Glu Asn Val Ala Lys Phe His Cys Pro 
            100                 105                 110         


His Cys Asp Thr Val Ile Ala Arg Lys Ser Asp Leu Gly Val His Leu 
        115                 120                 125             


Arg Lys Gln His Ser Tyr Ile Glu Gln Gly Lys Lys Cys Arg Tyr Cys 
    130                 135                 140                 


Asp Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Ser 
145                 150                 155                 160 


His Lys Asn Glu Lys Arg Phe Lys Cys Asp Gln Cys Asp Tyr Ala Cys 
                165                 170                 175     


Arg Gln Glu Arg His Met Ile Met His Lys Arg Thr His Thr Gly Glu 
            180                 185                 190         


Lys Pro Tyr Ala Cys Ser His Cys Asp Lys Thr Phe Arg Gln Lys Gln 
        195                 200                 205             


Leu Leu Asp Met His Phe Lys Arg Tyr His Asp Pro Asn Phe Val Pro 
    210                 215                 220                 


Ala Ala Phe Val Cys Ser Lys Cys Gly Lys Thr Phe Thr Arg Arg Asn 
225                 230                 235                 240 


Thr Met Ala Arg His Ala Asp Asn Cys Ala Gly Pro Asp Gly Val Glu 
                245                 250                 255     


Gly Glu Asn Gly Gly Glu Thr Lys Lys Ser Lys Arg Gly Arg Lys Arg 
            260                 265                 270         


Lys Met Arg Ser Lys Lys Glu Asp Ser Ser Asp Ser Glu Asn Ala Glu 
        275                 280                 285             


Pro Asp Leu Asp Asp Asn Glu Asp Glu Glu Glu Pro Ala Val Glu Ile 
    290                 295                 300                 


Glu Pro Glu Pro Glu Pro Gln Pro Val Thr Pro Ala Pro Pro Pro Ala 
305                 310                 315                 320 


Lys Lys Arg Arg Gly Arg Pro Pro Gly Arg Thr Asn Gln Pro Lys Gln 
                325                 330                 335     


Asn Gln Pro Thr Ala Ile Ile Gln Val Glu Asp Gln Asn Thr Gly Ala 
            340                 345                 350         


Ile Glu Asn Ile Ile Val Glu Val Lys Lys Glu Pro Asp Ala Glu Pro 
        355                 360                 365             


Ala Glu Gly Glu Glu Glu Glu Ala Gln Pro Ala Ala Thr Asp Ala Pro 
    370                 375                 380                 


Asn Gly Asp Leu Thr Pro Glu Met Ile Leu Ser Met Met Asp Arg 
385                 390                 395                 


<210>  2690
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTCFL__Homo_sapiens__NP_001255970

<400>  2690

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu 
            580                 585                 590         


Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Thr Thr Lys 
    610                 615                 620                 


Gly Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Thr 
625                 630                 635                 640 


Thr Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Thr Cys Glu Met 
                645                 650                 655     


Leu Leu Asn Thr Met Asp Lys 
            660             


<210>  2691
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTDP1__Homo_sapiens__NP_004706

<400>  2691

Met Glu Val Pro Ala Ala Gly Arg Val Pro Ala Glu Gly Ala Pro Thr 
1               5                   10                  15      


Ala Ala Val Ala Glu Val Arg Cys Pro Gly Pro Ala Pro Leu Arg Leu 
            20                  25                  30          


Leu Glu Trp Arg Val Ala Ala Gly Ala Ala Val Arg Ile Gly Ser Val 
        35                  40                  45              


Leu Ala Val Phe Glu Ala Ala Ala Ser Ala Gln Ser Ser Gly Ala Ser 
    50                  55                  60                  


Gln Ser Arg Val Ala Ser Gly Gly Cys Val Arg Pro Ala Arg Pro Glu 
65                  70                  75                  80  


Arg Arg Leu Arg Ser Glu Arg Ala Gly Val Val Arg Glu Leu Cys Ala 
                85                  90                  95      


Gln Pro Gly Gln Val Val Ala Pro Gly Ala Val Leu Val Arg Leu Glu 
            100                 105                 110         


Gly Cys Ser His Pro Val Val Met Lys Gly Leu Cys Ala Glu Cys Gly 
        115                 120                 125             


Gln Asp Leu Thr Gln Leu Gln Ser Lys Asn Gly Lys Gln Gln Val Pro 
    130                 135                 140                 


Leu Ser Thr Ala Thr Val Ser Met Val His Ser Val Pro Glu Leu Met 
145                 150                 155                 160 


Val Ser Ser Glu Gln Ala Glu Gln Leu Gly Arg Glu Asp Gln Gln Arg 
                165                 170                 175     


Leu His Arg Asn Arg Lys Leu Val Leu Met Val Asp Leu Asp Gln Thr 
            180                 185                 190         


Leu Ile His Thr Thr Glu Gln His Cys Gln Gln Met Ser Asn Lys Gly 
        195                 200                 205             


Ile Phe His Phe Gln Leu Gly Arg Gly Glu Pro Met Leu His Thr Arg 
    210                 215                 220                 


Leu Arg Pro His Cys Lys Asp Phe Leu Glu Lys Ile Ala Lys Leu Tyr 
225                 230                 235                 240 


Glu Leu His Val Phe Thr Phe Gly Ser Arg Leu Tyr Ala His Thr Ile 
                245                 250                 255     


Ala Gly Phe Leu Asp Pro Glu Lys Lys Leu Phe Ser His Arg Ile Leu 
            260                 265                 270         


Ser Arg Asp Glu Cys Ile Asp Pro Phe Ser Lys Thr Gly Asn Leu Arg 
        275                 280                 285             


Asn Leu Phe Pro Cys Gly Asp Ser Met Val Cys Ile Ile Asp Asp Arg 
    290                 295                 300                 


Glu Asp Val Trp Lys Phe Ala Pro Asn Leu Ile Thr Val Lys Lys Tyr 
305                 310                 315                 320 


Val Tyr Phe Gln Gly Thr Gly Asp Met Asn Ala Pro Pro Gly Ser Arg 
                325                 330                 335     


Glu Ser Gln Thr Arg Lys Lys Val Asn His Ser Arg Gly Thr Glu Val 
            340                 345                 350         


Ser Glu Pro Ser Pro Pro Val Arg Asp Pro Glu Gly Val Thr Gln Ala 
        355                 360                 365             


Pro Gly Val Glu Pro Ser Asn Gly Leu Glu Lys Pro Ala Arg Glu Leu 
    370                 375                 380                 


Asn Gly Ser Glu Ala Ala Thr Pro Arg Asp Ser Pro Arg Pro Gly Lys 
385                 390                 395                 400 


Pro Asp Glu Arg Asp Ile Trp Pro Pro Ala Gln Ala Pro Thr Ser Ser 
                405                 410                 415     


Gln Glu Leu Ala Gly Ala Pro Glu Pro Gln Gly Ser Cys Ala Gln Gly 
            420                 425                 430         


Gly Arg Val Ala Pro Gly Gln Arg Pro Ala Gln Gly Ala Thr Gly Thr 
        435                 440                 445             


Asp Leu Asp Phe Asp Leu Ser Ser Asp Ser Glu Ser Ser Ser Glu Ser 
    450                 455                 460                 


Glu Gly Thr Lys Ser Ser Ser Ser Ala Ser Asp Gly Glu Ser Glu Gly 
465                 470                 475                 480 


Lys Arg Gly Arg Gln Lys Pro Lys Ala Ala Pro Glu Gly Ala Gly Ala 
                485                 490                 495     


Leu Ala Gln Gly Ser Ser Leu Glu Pro Gly Arg Pro Ala Ala Pro Ser 
            500                 505                 510         


Leu Pro Gly Glu Ala Glu Pro Gly Ala His Ala Pro Asp Lys Glu Pro 
        515                 520                 525             


Glu Leu Gly Gly Gln Glu Glu Gly Glu Arg Asp Gly Leu Cys Gly Leu 
    530                 535                 540                 


Gly Asn Gly Cys Ala Asp Arg Lys Glu Ala Glu Thr Glu Ser Gln Asn 
545                 550                 555                 560 


Ser Glu Leu Ser Gly Val Thr Ala Gly Glu Ser Leu Asp Gln Ser Met 
                565                 570                 575     


Glu Glu Glu Glu Glu Glu Asp Thr Asp Glu Asp Asp His Leu Ile Tyr 
            580                 585                 590         


Leu Glu Glu Ile Leu Val Arg Val His Thr Asp Tyr Tyr Ala Lys Tyr 
        595                 600                 605             


Asp Arg Tyr Leu Asn Lys Glu Ile Glu Glu Ala Pro Asp Ile Arg Lys 
    610                 615                 620                 


Ile Val Pro Glu Leu Lys Ser Lys Val Leu Ala Asp Val Ala Ile Ile 
625                 630                 635                 640 


Phe Ser Gly Leu His Pro Thr Asn Phe Pro Ile Glu Lys Thr Arg Glu 
                645                 650                 655     


His Tyr His Ala Thr Ala Leu Gly Ala Lys Ile Leu Thr Arg Leu Val 
            660                 665                 670         


Leu Ser Pro Asp Ala Pro Asp Arg Ala Thr His Leu Ile Ala Ala Arg 
        675                 680                 685             


Ala Gly Thr Glu Lys Val Leu Gln Ala Gln Glu Cys Gly His Leu His 
    690                 695                 700                 


Val Val Asn Pro Asp Trp Leu Trp Ser Cys Leu Glu Arg Trp Asp Lys 
705                 710                 715                 720 


Val Glu Glu Gln Leu Phe Pro Leu Arg Asp Asp His Thr Lys Ala Gln 
                725                 730                 735     


Arg Glu Asn Ser Pro Ala Ala Phe Pro Asp Arg Glu Gly Val Pro Pro 
            740                 745                 750         


Thr Ala Leu Phe His Pro Met Pro Val Leu Pro Lys Ala Gln Pro Gly 
        755                 760                 765             


Pro Glu Val Arg Ile Tyr Asp Ser Asn Thr Gly Lys Leu Ile Arg Thr 
    770                 775                 780                 


Gly Ala Arg Gly Pro Pro Ala Pro Ser Ser Ser Leu Pro Ile Arg Gln 
785                 790                 795                 800 


Glu Pro Ser Ser Phe Arg Ala Val Pro Pro Pro Gln Pro Gln Met Phe 
                805                 810                 815     


Gly Glu Glu Leu Pro Asp Ala Gln Asp Gly Glu Gln Pro Gly Pro Ser 
            820                 825                 830         


Arg Arg Lys Arg Gln Pro Ser Met Ser Glu Thr Met Pro Leu Tyr Thr 
        835                 840                 845             


Leu Cys Lys Glu Asp Leu Glu Ser Met Asp Lys Glu Val Asp Asp Ile 
    850                 855                 860                 


Leu Gly Glu Gly Ser Asp Asp Ser Asp Ser Glu Lys Arg Arg Pro Glu 
865                 870                 875                 880 


Glu Gln Glu Glu Glu Pro Gln Pro Arg Lys Pro Gly Thr Arg Arg Glu 
                885                 890                 895     


Arg Thr Leu Gly Ala Pro Ala Ser Ser Glu Arg Ser Ala Ala Gly Gly 
            900                 905                 910         


Arg Gly Pro Arg Gly His Lys Arg Lys Leu Asn Glu Glu Asp Ala Ala 
        915                 920                 925             


Ser Glu Ser Ser Arg Glu Ser Ser Asn Glu Asp Glu Gly Ser Ser Ser 
    930                 935                 940                 


Glu Ala Asp Glu Met Ala Lys Ala Leu Glu Ala Glu Leu Asn Asp Leu 
945                 950                 955                 960 


Met 
    


<210>  2692
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTDSP1__Homo_sapiens__NP_001193807

<400>  2692

Met Val Ala Ala Pro Trp Ala Thr Gln Glu Gln Glu Glu Gly Arg Gly 
1               5                   10                  15      


Ile Gln Pro Gly Asp Arg Gly Asp Gln Lys Ser Ala Ala Ser Gln Lys 
            20                  25                  30          


Pro Arg Ser Arg Gly Ile Leu His Ser Leu Phe Cys Cys Val Cys Arg 
        35                  40                  45              


Asp Asp Gly Glu Ala Leu Pro Ala His Ser Gly Ala Pro Leu Leu Val 
    50                  55                  60                  


Glu Glu Asn Gly Ala Ile Pro Lys Thr Pro Val Gln Tyr Leu Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Ala Gln Asp Ser Asp Lys Ile Cys Val Val Ile Asp Leu 
                85                  90                  95      


Asp Glu Thr Leu Val His Ser Ser Phe Lys Pro Val Asn Asn Ala Asp 
            100                 105                 110         


Phe Ile Ile Pro Val Glu Ile Asp Gly Val Val His Gln Val Tyr Val 
        115                 120                 125             


Leu Lys Arg Pro His Val Asp Glu Phe Leu Gln Arg Met Gly Glu Leu 
    130                 135                 140                 


Phe Glu Cys Val Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp Pro 
145                 150                 155                 160 


Val Ala Asp Leu Leu Asp Lys Trp Gly Ala Phe Arg Ala Arg Leu Phe 
                165                 170                 175     


Arg Glu Ser Cys Val Phe His Arg Gly Asn Tyr Val Lys Asp Leu Ser 
            180                 185                 190         


Arg Leu Gly Arg Asp Leu Arg Arg Val Leu Ile Leu Asp Asn Ser Pro 
        195                 200                 205             


Ala Ser Tyr Val Phe His Pro Asp Asn Ala Val Pro Val Ala Ser Trp 
    210                 215                 220                 


Phe Asp Asn Met Ser Asp Thr Glu Leu His Asp Leu Leu Pro Phe Phe 
225                 230                 235                 240 


Glu Gln Leu Ser Arg Val Asp Asp Val Tyr Ser Val Leu Arg Gln Pro 
                245                 250                 255     


Arg Pro Gly Ser 
            260 


<210>  2693
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTDSP2__Homo_sapiens__NP_005721

<400>  2693

Met Glu His Gly Ser Ile Ile Thr Gln Ala Arg Arg Glu Asp Ala Leu 
1               5                   10                  15      


Val Leu Thr Lys Gln Gly Leu Val Ser Lys Ser Ser Pro Lys Lys Pro 
            20                  25                  30          


Arg Gly Arg Asn Ile Phe Lys Ala Leu Phe Cys Cys Phe Arg Ala Gln 
        35                  40                  45              


His Val Gly Gln Ser Ser Ser Ser Thr Glu Leu Ala Ala Tyr Lys Glu 
    50                  55                  60                  


Glu Ala Asn Thr Ile Ala Lys Ser Asp Leu Leu Gln Cys Leu Gln Tyr 
65                  70                  75                  80  


Gln Phe Tyr Gln Ile Pro Gly Thr Cys Leu Leu Pro Glu Val Thr Glu 
                85                  90                  95      


Glu Asp Gln Gly Arg Ile Cys Val Val Ile Asp Leu Asp Glu Thr Leu 
            100                 105                 110         


Val His Ser Ser Phe Lys Pro Ile Asn Asn Ala Asp Phe Ile Val Pro 
        115                 120                 125             


Ile Glu Ile Glu Gly Thr Thr His Gln Val Tyr Val Leu Lys Arg Pro 
    130                 135                 140                 


Tyr Val Asp Glu Phe Leu Arg Arg Met Gly Glu Leu Phe Glu Cys Val 
145                 150                 155                 160 


Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp Pro Val Thr Asp Leu 
                165                 170                 175     


Leu Asp Arg Cys Gly Val Phe Arg Ala Arg Leu Phe Arg Glu Ser Cys 
            180                 185                 190         


Val Phe His Gln Gly Cys Tyr Val Lys Asp Leu Ser Arg Leu Gly Arg 
        195                 200                 205             


Asp Leu Arg Lys Thr Leu Ile Leu Asp Asn Ser Pro Ala Ser Tyr Ile 
    210                 215                 220                 


Phe His Pro Glu Asn Ala Val Pro Val Gln Ser Trp Phe Asp Asp Met 
225                 230                 235                 240 


Ala Asp Thr Glu Leu Leu Asn Leu Ile Pro Ile Phe Glu Glu Leu Ser 
                245                 250                 255     


Gly Ala Glu Asp Val Tyr Thr Ser Leu Gly Gln Leu Arg Ala Pro 
            260                 265                 270     


<210>  2694
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTDSPL__Homo_sapiens__NP_001008393

<400>  2694

Met Asp Gly Pro Ala Ile Ile Thr Gln Val Thr Asn Pro Lys Glu Asp 
1               5                   10                  15      


Glu Gly Arg Leu Pro Gly Ala Gly Glu Lys Ala Ser Gln Cys Asn Val 
            20                  25                  30          


Ser Leu Lys Lys Gln Arg Ser Arg Ser Ile Leu Ser Ser Phe Phe Cys 
        35                  40                  45              


Cys Phe Arg Asp Tyr Asn Val Glu Ala Pro Pro Pro Ser Ser Pro Ser 
    50                  55                  60                  


Val Leu Pro Pro Leu Val Glu Glu Asn Gly Gly Leu Gln Lys Gly Asp 
65                  70                  75                  80  


Gln Arg Gln Val Ile Pro Ile Pro Ser Pro Pro Ala Lys Tyr Leu Leu 
                85                  90                  95      


Pro Glu Val Thr Val Leu Asp Tyr Gly Lys Lys Cys Val Val Ile Asp 
            100                 105                 110         


Leu Asp Glu Thr Leu Val His Ser Ser Phe Lys Pro Ile Ser Asn Ala 
        115                 120                 125             


Asp Phe Ile Val Pro Val Glu Ile Asp Gly Thr Ile His Gln Val Tyr 
    130                 135                 140                 


Val Leu Lys Arg Pro His Val Asp Glu Phe Leu Gln Arg Met Gly Gln 
145                 150                 155                 160 


Leu Phe Glu Cys Val Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp 
                165                 170                 175     


Pro Val Ala Asp Leu Leu Asp Arg Trp Gly Val Phe Arg Ala Arg Leu 
            180                 185                 190         


Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn Tyr Val Lys Asp Leu 
        195                 200                 205             


Ser Arg Leu Gly Arg Glu Leu Ser Lys Val Ile Ile Val Asp Asn Ser 
    210                 215                 220                 


Pro Ala Ser Tyr Ile Phe His Pro Glu Asn Ala Val Pro Val Gln Ser 
225                 230                 235                 240 


Trp Phe Asp Asp Met Thr Asp Thr Glu Leu Leu Asp Leu Ile Pro Phe 
                245                 250                 255     


Phe Glu Gly Leu Ser Arg Glu Asp Asp Val Tyr Ser Met Leu His Arg 
            260                 265                 270         


Leu Cys Asn Arg 
        275     


<210>  2695
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTF1__Homo_sapiens__NP_001136016

<400>  2695

Met Ser Arg Arg Glu Gly Ser Leu Asp Pro Gln Thr Asp Ser Ser Val 
1               5                   10                  15      


Ser Leu Leu Pro His Leu Glu Ala Lys Ile Arg Gln Thr His Ser Leu 
            20                  25                  30          


Ala His Leu Leu Thr Lys Tyr Ala Glu Gln Leu Leu Gln Glu Tyr Val 
        35                  40                  45              


Gln Leu Gln Gly Asp Pro Phe Gly Leu Pro Ser Phe Ser Pro Pro Arg 
    50                  55                  60                  


Leu Pro Val Ala Gly Leu Ser Ala Pro Ala Pro Ser His Ala Gly Leu 
65                  70                  75                  80  


Pro Val His Glu Arg Leu Arg Leu Asp Ala Ala Ala Leu Ala Ala Leu 
                85                  90                  95      


Pro Pro Leu Leu Asp Ala Val Cys Arg Arg Gln Ala Glu Leu Asn Pro 
            100                 105                 110         


Arg Ala Pro Arg Leu Leu Arg Arg Leu Glu Asp Ala Ala Arg Gln Ala 
        115                 120                 125             


Arg Ala Leu Gly Ala Ala Val Glu Ala Leu Leu Ala Ala Leu Gly Ala 
    130                 135                 140                 


Ala Asn Arg Gly Pro Arg Ala Glu Pro Pro Ala Ala Thr Ala Ser Ala 
145                 150                 155                 160 


Ala Ser Ala Thr Gly Val Phe Pro Ala Lys Val Leu Gly Leu Arg Val 
                165                 170                 175     


Cys Gly Leu Tyr Arg Glu Trp Leu Ser Arg Thr Glu Gly Asp Leu Gly 
            180                 185                 190         


Gln Leu Leu Pro Gly Gly Ser Ala 
        195                 200 


<210>  2696
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTGF__Homo_sapiens__NP_001892

<400>  2696

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 


<210>  2697
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTHRC1__Homo_sapiens__NP_001243028

<400>  2697

Met Trp Pro Pro Gly Arg Ser Ile Thr Val Lys Leu Arg Glu Lys Thr 
1               5                   10                  15      


Val Ser Arg Lys Leu Glu Met Asn Gly Pro Ser Ala Phe Gln Gly Leu 
            20                  25                  30          


Ile Cys Gly Lys Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly Val 
        35                  40                  45              


Pro Gly Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Thr Pro 
    50                  55                  60                  


Gly Ile Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys Leu 
65                  70                  75                  80  


Arg Glu Ser Phe Glu Glu Ser Trp Thr Pro Asn Tyr Lys Gln Cys Ser 
                85                  90                  95      


Trp Ser Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Glu Cys 
            100                 105                 110         


Thr Phe Thr Lys Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe Ser 
        115                 120                 125             


Gly Ser Leu Arg Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp Tyr 
    130                 135                 140                 


Phe Thr Phe Asn Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu Ala 
145                 150                 155                 160 


Ile Ile Tyr Leu Asp Gln Gly Ser Pro Glu Met Asn Ser Thr Ile Asn 
                165                 170                 175     


Ile His Arg Thr Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly Ala 
            180                 185                 190         


Gly Leu Val Asp Val Ala Ile Trp Val Gly Thr Cys Ser Asp Tyr Pro 
        195                 200                 205             


Lys Gly Asp Ala Ser Thr Gly Trp Asn Ser Val Ser Arg Ile Ile Ile 
    210                 215                 220                 


Glu Glu Leu Pro Lys 
225                 


<210>  2698
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTIF__Homo_sapiens__NP_001135869

<400>  2698

Met Glu Asn Ser Ser Ala Ala Ser Ala Ser Ser Glu Ala Gly Ser Ser 
1               5                   10                  15      


Arg Ser Gln Glu Ile Glu Glu Leu Glu Arg Phe Ile Asp Ser Tyr Val 
            20                  25                  30          


Leu Glu Tyr Gln Val Gln Gly Leu Leu Ala Asp Lys Thr Glu Gly Asp 
        35                  40                  45              


Gly Glu Ser Glu Arg Thr Gln Ser His Ile Ser Gln Trp Thr Ala Asp 
    50                  55                  60                  


Cys Ser Glu Pro Leu Asp Ser Ser Cys Ser Phe Ser Arg Gly Arg Ala 
65                  70                  75                  80  


Pro Pro Gln Gln Asn Gly Ser Lys Asp Asn Ser Leu Asp Met Leu Gly 
                85                  90                  95      


Thr Asp Ile Trp Ala Ala Asn Thr Phe Asp Ser Phe Ser Gly Ala Thr 
            100                 105                 110         


Trp Asp Leu Gln Pro Glu Lys Leu Asp Phe Thr Gln Phe His Arg Lys 
        115                 120                 125             


Val Arg His Thr Pro Lys Gln Pro Leu Pro His Ile Asp Arg Glu Gly 
    130                 135                 140                 


Cys Gly Lys Gly Lys Leu Glu Asp Gly Asp Gly Ile Asn Leu Asn Asp 
145                 150                 155                 160 


Ile Glu Lys Val Leu Pro Ala Trp Gln Gly Tyr His Pro Met Pro His 
                165                 170                 175     


Glu Val Glu Ile Ala His Thr Lys Lys Leu Phe Arg Arg Arg Arg Asn 
            180                 185                 190         


Asp Arg Arg Arg Gln Gln Arg Pro Pro Gly Gly Asn Lys Pro Gln Gln 
        195                 200                 205             


His Gly Asp His Gln Pro Gly Ser Ala Lys His Asn Arg Asp His Gln 
    210                 215                 220                 


Lys Ser Tyr Gln Gly Gly Ser Ala Pro His Pro Ser Gly Arg Pro Thr 
225                 230                 235                 240 


His His Gly Tyr Ser Gln Asn Arg Arg Trp His His Gly Asn Met Lys 
                245                 250                 255     


His Pro Pro Gly Asp Lys Gly Glu Ala Gly Ala His Arg Asn Ala Lys 
            260                 265                 270         


Glu Thr Met Thr Ile Glu Asn Pro Lys Leu Glu Asp Thr Ala Gly Asp 
        275                 280                 285             


Thr Gly His Ser Ser Leu Glu Ala Pro Arg Ser Pro Asp Thr Leu Ala 
    290                 295                 300                 


Pro Val Ala Ser Glu Arg Leu Pro Pro Gln Gln Ser Gly Gly Pro Glu 
305                 310                 315                 320 


Val Glu Thr Lys Arg Lys Asp Ser Ile Leu Pro Glu Arg Ile Gly Glu 
                325                 330                 335     


Arg Pro Lys Ile Thr Leu Leu Gln Ser Ser Lys Asp Arg Leu Arg Arg 
            340                 345                 350         


Arg Leu Lys Glu Lys Val Pro Asp Glu Val Ala Val Glu Thr Thr Thr 
        355                 360                 365             


Pro Gln Gln Asn Lys Met Asp Lys Leu Ile Glu Ile Leu Asn Ser Met 
    370                 375                 380                 


Arg Asn Asn Ser Ser Asp Val Asp Thr Lys Leu Thr Thr Phe Met Glu 
385                 390                 395                 400 


Glu Ala Gln Asn Ser Thr Asn Ser Glu Glu Met Leu Gly Glu Ile Val 
                405                 410                 415     


Arg Thr Ile Tyr Gln Lys Ala Val Ser Asp Arg Ser Phe Ala Phe Thr 
            420                 425                 430         


Ala Ala Lys Leu Cys Asp Lys Met Ala Leu Phe Met Val Glu Gly Thr 
        435                 440                 445             


Lys Phe Arg Ser Leu Leu Leu Asn Met Leu Gln Lys Asp Phe Thr Val 
    450                 455                 460                 


Arg Glu Glu Leu Gln Gln Gln Asp Val Glu Arg Trp Leu Gly Phe Ile 
465                 470                 475                 480 


Thr Phe Leu Cys Glu Val Phe Gly Thr Met Arg Ser Ser Thr Gly Glu 
                485                 490                 495     


Pro Phe Arg Val Leu Val Cys Pro Ile Tyr Thr Cys Leu Arg Glu Leu 
            500                 505                 510         


Leu Gln Ser Gln Asp Val Lys Glu Asp Ala Val Leu Cys Cys Ser Met 
        515                 520                 525             


Glu Leu Gln Ser Thr Gly Arg Leu Leu Glu Glu Gln Leu Pro Glu Met 
    530                 535                 540                 


Met Thr Glu Leu Leu Ala Ser Ala Arg Asp Lys Met Leu Cys Pro Ser 
545                 550                 555                 560 


Glu Ser Met Leu Thr Arg Ser Leu Leu Leu Glu Val Ile Glu Leu His 
                565                 570                 575     


Ala Asn Ser Trp Asn Pro Leu Thr Pro Pro Ile Thr Gln Tyr Tyr Asn 
            580                 585                 590         


Arg Thr Ile Gln Lys Leu Thr Ala 
        595                 600 


<210>  2699
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA4__Homo_sapiens__NP_001032720

<400>  2699

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr 
145                 150                 155                 160 


Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
                165                 170                 


<210>  2700
<211>  841
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNNA1__Homo_sapiens__NP_001277236

<400>  2700

Met Thr Ala Val His Ala Gly Asn Ile Asn Phe Lys Trp Asp Pro Lys 
1               5                   10                  15      


Ser Leu Glu Ile Arg Thr Leu Ala Val Glu Arg Leu Leu Glu Pro Leu 
            20                  25                  30          


Val Thr Gln Val Thr Thr Leu Val Asn Thr Asn Ser Lys Gly Pro Ser 
        35                  40                  45              


Asn Lys Lys Arg Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser 
    50                  55                  60                  


Val Glu Gln Ala Thr Glu Asn Phe Leu Glu Lys Gly Asp Lys Ile Ala 
65                  70                  75                  80  


Lys Glu Ser Gln Phe Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp 
                85                  90                  95      


Val Arg Lys Gln Gly Asp Leu Met Lys Ala Ala Ala Gly Glu Phe Ala 
            100                 105                 110         


Asp Asp Pro Cys Ser Ser Val Lys Arg Gly Asn Met Val Arg Ala Ala 
        115                 120                 125             


Arg Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met 
    130                 135                 140                 


Ala Asp Val Tyr Lys Leu Leu Val Gln Leu Lys Val Val Glu Asp Gly 
145                 150                 155                 160 


Ile Leu Lys Leu Arg Asn Ala Gly Asn Glu Gln Asp Leu Gly Ile Gln 
                165                 170                 175     


Tyr Lys Ala Leu Lys Pro Glu Val Asp Lys Leu Asn Ile Met Ala Ala 
            180                 185                 190         


Lys Arg Gln Gln Glu Leu Lys Asp Val Gly His Arg Asp Gln Met Ala 
        195                 200                 205             


Ala Ala Arg Gly Ile Leu Gln Lys Asn Val Pro Ile Leu Tyr Thr Ala 
    210                 215                 220                 


Ser Gln Ala Cys Leu Gln His Pro Asp Val Ala Ala Tyr Lys Ala Asn 
225                 230                 235                 240 


Arg Asp Leu Ile Tyr Lys Gln Leu Gln Gln Ala Val Thr Gly Ile Ser 
                245                 250                 255     


Asn Ala Ala Gln Ala Thr Ala Ser Asp Asp Ala Ser Gln His Gln Gly 
            260                 265                 270         


Gly Gly Gly Gly Glu Leu Ala Tyr Ala Leu Asn Asn Phe Asp Lys Gln 
        275                 280                 285             


Ile Ile Val Asp Pro Leu Ser Phe Ser Glu Glu Arg Phe Arg Pro Ser 
    290                 295                 300                 


Leu Glu Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala 
305                 310                 315                 320 


Asp Ser Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu 
                325                 330                 335     


Cys Asn Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met 
            340                 345                 350         


Gly Asn Ala Gly Arg Lys Glu Arg Ser Asp Ala Leu Asn Ser Ala Ile 
        355                 360                 365             


Asp Lys Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys 
    370                 375                 380                 


Ala Val Met Asp His Val Ser Asp Ser Phe Leu Glu Thr Asn Val Pro 
385                 390                 395                 400 


Leu Leu Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val 
                405                 410                 415     


Lys Glu Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu 
            420                 425                 430         


Val Ala Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys 
        435                 440                 445             


Leu Val Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val 
    450                 455                 460                 


Ile Asn Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala 
465                 470                 475                 480 


Gln Glu Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg 
                485                 490                 495     


Val Leu Thr Asp Ala Val Asp Asp Ile Thr Ser Ile Asp Asp Phe Leu 
            500                 505                 510         


Ala Val Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile 
        515                 520                 525             


Ala Leu Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Thr Ala Gly Ala 
    530                 535                 540                 


Ile Arg Gly Arg Ala Ala Arg Val Ile His Val Val Thr Ser Glu Met 
545                 550                 555                 560 


Asp Asn Tyr Glu Pro Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr 
                565                 570                 575     


Lys Leu Leu Ser Asn Thr Val Met Pro Arg Phe Thr Glu Gln Val Glu 
            580                 585                 590         


Ala Ala Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu 
        595                 600                 605             


Asn Glu Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp 
    610                 615                 620                 


Ile Arg Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Asp Asp 
625                 630                 635                 640 


Ser Asp Phe Glu Thr Glu Asp Phe Asp Val Arg Ser Arg Thr Ser Val 
                645                 650                 655     


Gln Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile 
            660                 665                 670         


Met Ala Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val 
        675                 680                 685             


Ala Ser Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys 
    690                 695                 700                 


Trp Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys 
705                 710                 715                 720 


Met Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu 
                725                 730                 735     


Lys Asn Thr Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala 
            740                 745                 750         


Gly Ser Arg Met Asp Lys Leu Gly Arg Thr Ile Ala Asp His Cys Pro 
        755                 760                 765             


Asp Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala 
    770                 775                 780                 


Leu Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val 
785                 790                 795                 800 


Gln Asn Leu Gly Gly Glu Leu Val Val Ser Gly Asn Cys Asp Thr Cys 
                805                 810                 815     


Gly Ala Leu Gln Gly Leu Lys Gly Trp Pro Pro Pro Leu Cys Trp Pro 
            820                 825                 830         


Leu Thr Gly Trp Thr Ala Pro Cys Pro 
        835                 840     


<210>  2701
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNNA2__Homo_sapiens__NP_001158355

<400>  2701

Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser 
1               5                   10                  15      


Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val 
            20                  25                  30          


Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly 
        35                  40                  45              


Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val 
    50                  55                  60                  


Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys 
65                  70                  75                  80  


Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val 
                85                  90                  95      


Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp 
            100                 105                 110         


Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg 
        115                 120                 125             


Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala 
    130                 135                 140                 


Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu 
145                 150                 155                 160 


Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe 
                165                 170                 175     


Lys Glu Phe Gly Lys Glu Met Val Lys Leu Asn Tyr Val Ala Ala Arg 
            180                 185                 190         


Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala 
        195                 200                 205             


Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser 
    210                 215                 220                 


Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg 
225                 230                 235                 240 


Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn 
                245                 250                 255     


Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly 
            260                 265                 270         


Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile 
        275                 280                 285             


Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu 
    290                 295                 300                 


Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp Ser 
305                 310                 315                 320 


Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys Asn 
                325                 330                 335     


Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn Asn 
            340                 345                 350         


Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp Lys 
        355                 360                 365             


Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val 
    370                 375                 380                 


Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu 
385                 390                 395                 400 


Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys Glu 
                405                 410                 415     


Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val Ala 
            420                 425                 430         


Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val 
        435                 440                 445             


Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile Asn 
    450                 455                 460                 


Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln Asp 
465                 470                 475                 480 


Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val Leu 
                485                 490                 495     


Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser Val 
            500                 505                 510         


Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu 
        515                 520                 525             


Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile Arg 
    530                 535                 540                 


Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu Asn 
545                 550                 555                 560 


Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu 
                565                 570                 575     


Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val Ala 
            580                 585                 590         


Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn Glu 
        595                 600                 605             


Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile Arg 
    610                 615                 620                 


Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp Ser 
625                 630                 635                 640 


Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Ser Arg Thr Ser Val Gln 
                645                 650                 655     


Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met 
            660                 665                 670         


Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val Glu 
        675                 680                 685             


Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys Trp 
    690                 695                 700                 


Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met 
705                 710                 715                 720 


Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys 
                725                 730                 735     


Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala Gly 
            740                 745                 750         


Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Leu Asp Ser 
        755                 760                 765             


Ala Thr Ser Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val 
    770                 775                 780                 


Leu Thr Val Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val 
785                 790                 795                 800 


Tyr Gly Thr Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys 
                805                 810                 815     


Ala Pro Glu Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe 
            820                 825                 830         


Gln Thr Arg Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val 
        835                 840                 845             


Gln Ala Leu Ser Glu Phe Lys Ala Met Asp Ser Phe 
    850                 855                 860 


<210>  2702
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNNA3__Homo_sapiens__NP_001278062

<400>  2702

Met Lys Ser Thr Gln Arg Arg Glu Lys Gln Gly Ser Met Ser Ala Glu 
1               5                   10                  15      


Thr Pro Ile Thr Leu Asn Ile Asp Pro Gln Asp Leu Gln Val Gln Thr 
            20                  25                  30          


Phe Thr Val Glu Lys Leu Leu Glu Pro Leu Ile Ile Gln Val Thr Thr 
        35                  40                  45              


Leu Val Asn Cys Pro Gln Asn Pro Ser Ser Arg Lys Lys Gly Arg Ser 
    50                  55                  60                  


Lys Arg Ala Ser Val Leu Leu Ala Ser Val Glu Glu Ala Thr Trp Asn 
65                  70                  75                  80  


Leu Leu Asp Lys Gly Glu Lys Ile Ala Gln Glu Ala Thr Val Leu Lys 
                85                  90                  95      


Asp Glu Leu Thr Ala Ser Leu Glu Glu Val Arg Lys Glu Ser Glu Ala 
            100                 105                 110         


Leu Lys Val Ser Ala Glu Arg Phe Thr Asp Asp Pro Cys Phe Leu Pro 
        115                 120                 125             


Lys Arg Glu Ala Val Val Gln Ala Ala Arg Ala Leu Leu Ala Ala Val 
    130                 135                 140                 


Thr Arg Leu Leu Ile Leu Ala Asp Met Ile Asp Val Met Cys Leu Leu 
145                 150                 155                 160 


Gln His Val Ser Ala Phe Gln Arg Thr Phe Glu Ser Leu Lys Asn Val 
                165                 170                 175     


Ala Asn Lys Ser Asp Leu Gln Lys Thr Tyr Gln Lys Leu Gly Lys Glu 
            180                 185                 190         


Leu Glu Asn Leu Asp Tyr Leu Ala Phe Lys Arg Gln Gln Asp Leu Lys 
        195                 200                 205             


Ser Pro Asn Gln Arg Asp Glu Ile Ala Gly Ala Arg Ala Ser Leu Lys 
    210                 215                 220                 


Glu Asn Ser Pro Leu Leu His Ser Ile Cys Ser Ala Cys Leu Glu His 
225                 230                 235                 240 


Ser Asp Val Ala Ser Leu Lys Ala Ser Lys Asp Thr Val Cys Glu Glu 
                245                 250                 255     


Ile Gln Asn Ala Leu Asn Val Ile Ser Asn Ala Ser Gln Gly Ile Gln 
            260                 265                 270         


Asn Met Thr Thr Pro Pro Glu Pro Gln Ala Ala Thr Leu Gly Ser Ala 
        275                 280                 285             


Leu Asp Glu Leu Glu Asn Leu Ile Val Leu Asn Pro Leu Thr Val Thr 
    290                 295                 300                 


Glu Glu Glu Ile Arg Pro Ser Leu Glu Lys Arg Leu Glu Ala Ile Ile 
305                 310                 315                 320 


Ser Gly Ala Ala Leu Leu Ala Asp Ser Ser Cys Thr Arg Asp Leu His 
                325                 330                 335     


Arg Glu Arg Ile Ile Ala Glu Cys Asn Ala Ile Arg Gln Ala Leu Gln 
            340                 345                 350         


Asp Leu Leu Ser Glu Tyr Met Asn Asn Leu Cys Asn Gln Lys Ser Asp 
        355                 360                 365             


Leu Gly Leu Thr Gly Val Lys Ile Lys Leu Leu Glu Glu Cys Ile Ile 
    370                 375                 380                 


Phe Trp Ser Leu 
385             


<210>  2703
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNNAL1__Homo_sapiens__NP_001273903

<400>  2703

Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Thr Arg Ser Val Glu Gln Thr Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Thr Thr Leu Ile Asn His Lys Asp Asn Thr Lys Lys Ser Asp Lys Thr 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Thr Ile Ala Ala Leu Thr Asp Ile Thr Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Thr Ile Phe Thr Asp Lys Thr Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Thr Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Thr Ser Arg Asn Lys Val Leu Ala 
                165                 170                 175     


Thr Met Glu Arg Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln 
            180                 185                 190         


Ile Phe Ser Gln Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser 
        195                 200                 205             


Gly Asp Arg Gln Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met 
    210                 215                 220                 


Ala Ala Ala Arg Ala Val Leu Glu Lys Cys Thr Met Met Leu Leu Thr 
225                 230                 235                 240 


Ala Ser Lys Thr Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys 
                245                 250                 255     


Asn Lys Glu Gly Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val 
            260                 265                 270         


Ile Glu Ile Val Thr Asp Cys Lys Pro Asn Gly Glu Thr Asp Ile Ser 
        275                 280                 285             


Ser Ile Ser Ile Phe Thr Gly Ile Lys Glu Phe Lys Met Asn Ile Glu 
    290                 295                 300                 


Ala Leu Arg Glu Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val 
305                 310                 315                 320 


Thr Leu Glu Val Ile Leu Glu Arg Met Glu Asp Phe Thr Asp Ser Ala 
                325                 330                 335     


Tyr Thr Ser His Glu His Arg Glu Arg Ile Leu Glu Leu Ser Thr Gln 
            340                 345                 350         


Ala Arg Met Glu Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln 
        355                 360                 365             


Ser Lys Lys Thr Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu 
    370                 375                 380                 


Lys Ile Ser His Ser Leu Asn Glu Leu Lys Lys Glu Leu His Ser Thr 
385                 390                 395                 400 


Ala Thr Gln Leu Ala Ala Asp Leu Leu Lys Tyr His Ala Asp His Val 
                405                 410                 415     


Val Leu Lys Ala Leu Lys Leu Thr Gly Val Glu Gly Asn Leu Glu Ala 
            420                 425                 430         


Leu Ala Glu Tyr Ala Cys Lys Leu Ser Glu Gln Lys Glu Gln Leu Val 
        435                 440                 445             


Glu Thr Cys Arg Leu Leu Arg His Ile Ser Gly Thr Glu Pro Leu Glu 
    450                 455                 460                 


Ile Thr Cys Ile His Ala Glu Glu Thr Phe Gln Val Thr Gly Gln Gln 
465                 470                 475                 480 


Ile Ile Ser Ala Ala Glu Thr Leu Thr Leu His Pro Ser Ser Lys Ile 
                485                 490                 495     


Ala Lys Glu Asn Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile 
            500                 505                 510         


Ser Asp Met Ser Thr Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly 
        515                 520                 525             


Arg Arg Gly Glu Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys 
    530                 535                 540                 


Asn Asn Ala Asn Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu 
545                 550                 555                 560 


Glu Gln Ala Lys Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Thr 
                565                 570                 575     


Ser Asp Ala Asp Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu 
            580                 585                 590         


Ile Val Gln Tyr Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr 
        595                 600                 605             


Leu Phe Thr Arg Gly Glu Gly Pro Leu Lys Thr Ser Gln Asp Leu Ile 
    610                 615                 620                 


His Gln Leu Glu Val Phe Ala Ala Glu Gly Leu Lys Leu Thr Ser Ser 
625                 630                 635                 640 


Val Gln Ala Phe Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu 
                645                 650                 655     


Leu Leu Glu Ile Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Thr 
            660                 665                 670         


Val Thr Lys Thr Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys 
        675                 680                 685             


Cys Ile Thr Lys Thr Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu 
    690                 695                 700                 


Ser Leu Cys Tyr Lys Leu Leu Lys Lys Ser Glu Thr Arg Tyr 
705                 710                 715             


<210>  2704
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNNB1__Homo_sapiens__NP_001091679

<400>  2704

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  2705
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNNBL1__Homo_sapiens__NP_001268424

<400>  2705

Met Arg Arg Lys Gln Thr Gly Thr Arg Glu Arg Gly Arg Tyr Arg Glu 
1               5                   10                  15      


Glu Glu Met Thr Val Val Glu Glu Ala Asp Asp Asp Lys Lys Arg Leu 
            20                  25                  30          


Leu Gln Ile Ile Asp Arg Asp Gly Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Pro Leu Asp Glu Ser Ser Val Lys Lys Met Ile Leu Thr Phe Glu Lys 
    50                  55                  60                  


Arg Ser Tyr Lys Asn Gln Glu Leu Arg Ile Lys Phe Pro Asp Asn Pro 
65                  70                  75                  80  


Glu Lys Phe Met Glu Ser Glu Leu Asp Leu Asn Asp Ile Ile Gln Glu 
                85                  90                  95      


Met His Val Val Ala Thr Met Pro Asp Leu Tyr His Leu Leu Val Glu 
            100                 105                 110         


Leu Asn Ala Val Gln Ser Leu Leu Gly Leu Leu Gly His Asp Asn Thr 
        115                 120                 125             


Asp Val Ser Ile Ala Val Val Asp Leu Leu Gln Glu Leu Thr Asp Ile 
    130                 135                 140                 


Asp Thr Leu His Glu Ser Glu Glu Gly Ala Glu Val Leu Ile Asp Ala 
145                 150                 155                 160 


Leu Val Asp Gly Gln Val Val Ala Leu Leu Val Gln Asn Leu Glu Arg 
                165                 170                 175     


Leu Asp Glu Ser Val Lys Glu Glu Ala Asp Gly Val His Asn Thr Leu 
            180                 185                 190         


Ala Ile Val Glu Asn Met Ala Glu Phe Arg Pro Glu Met Cys Thr Glu 
        195                 200                 205             


Gly Ala Gln Gln Gly Leu Leu Gln Trp Leu Leu Lys Arg Leu Lys Ala 
    210                 215                 220                 


Lys Met Pro Phe Asp Ala Asn Lys Leu Tyr Cys Ser Glu Val Leu Ala 
225                 230                 235                 240 


Ile Leu Leu Gln Asp Asn Asp Glu Asn Arg Glu Leu Leu Gly Glu Leu 
                245                 250                 255     


Asp Gly Ile Asp Val Leu Leu Gln Gln Leu Ser Val Phe Lys Arg His 
            260                 265                 270         


Asn Pro Ser Thr Ala Glu Glu Gln Glu Met Met Glu Asn Leu Phe Asp 
        275                 280                 285             


Ser Leu Cys Ser Cys Leu Met Leu Ser Ser Asn Arg Glu Arg Phe Leu 
    290                 295                 300                 


Lys Gly Glu Gly Leu Gln Leu Met Asn Leu Met Leu Arg Glu Lys Lys 
305                 310                 315                 320 


Ile Ser Arg Ser Ser Ala Leu Lys Val Leu Asp His Ala Met Ile Gly 
                325                 330                 335     


Pro Glu Gly Thr Asp Asn Cys His Lys Phe Val Asp Ile Leu Gly Leu 
            340                 345                 350         


Arg Thr Ile Phe Pro Leu Phe Met Lys Ser Pro Arg Lys Ile Lys Lys 
        355                 360                 365             


Val Gly Thr Thr Glu Lys Glu His Glu Glu His Val Cys Ser Ile Leu 
    370                 375                 380                 


Ala Ser Leu Leu Arg Asn Leu Arg Gly Gln Gln Arg Thr Arg Leu Leu 
385                 390                 395                 400 


Asn Lys Phe Thr Glu Asn Asp Ser Glu Lys Val Asp Arg Leu Met Glu 
                405                 410                 415     


Leu His Phe Lys Tyr Leu Gly Ala Met Gln Val Ala Asp Lys Lys Ile 
            420                 425                 430         


Glu Gly Glu Lys His Asp Met Val Arg Arg Gly Glu Ile Ile Asp Asn 
        435                 440                 445             


Asp Thr Glu Glu Glu Phe Tyr Leu Arg Arg Leu Asp Ala Gly Leu Phe 
    450                 455                 460                 


Val Leu Gln His Ile Cys Tyr Ile Met Ala Glu Ile Cys Asn Ala Asn 
465                 470                 475                 480 


Val Pro Gln Ile Arg Gln Arg Val His Gln Ile Leu Asn Met Arg Gly 
                485                 490                 495     


Ser Ser Ile Lys Ile Val Arg His Ile Ile Lys Glu Tyr Ala Glu Asn 
            500                 505                 510         


Ile Gly Asp Gly Arg Ser Pro Glu Phe Arg Glu Asn Glu Gln Lys Arg 
        515                 520                 525             


Ile Leu Gly Leu Leu Glu Asn Phe 
    530                 535     


<210>  2706
<211>  968
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNND1__Homo_sapiens__NP_001078927

<400>  2706

Met Asp Asp Ser Glu Val Glu Ser Thr Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Gln Phe Glu Lys Leu Thr Arg Ala Leu Glu Glu 
            20                  25                  30          


Glu Arg Arg His Val Ser Ala Gln Leu Glu Arg Val Arg Val Ser Pro 
        35                  40                  45              


Gln Asp Ala Asn Pro Leu Met Ala Asn Gly Thr Leu Thr Arg Arg His 
    50                  55                  60                  


Gln Asn Gly Arg Phe Val Gly Asp Ala Asp Leu Glu Arg Gln Lys Phe 
65                  70                  75                  80  


Ser Asp Leu Lys Leu Asn Gly Pro Gln Asp His Ser His Leu Leu Tyr 
                85                  90                  95      


Ser Thr Ile Pro Arg Met Gln Glu Pro Gly Gln Ile Val Glu Thr Tyr 
            100                 105                 110         


Thr Glu Glu Asp Pro Glu Gly Ala Met Ser Val Val Ser Val Glu Thr 
        115                 120                 125             


Ser Asp Asp Gly Thr Thr Arg Arg Thr Glu Thr Thr Val Lys Lys Val 
    130                 135                 140                 


Val Lys Thr Val Thr Thr Arg Thr Val Gln Pro Val Ala Met Gly Pro 
145                 150                 155                 160 


Asp Gly Leu Pro Val Asp Ala Ser Ser Val Ser Asn Asn Tyr Ile Gln 
                165                 170                 175     


Thr Leu Gly Arg Asp Phe Arg Lys Asn Gly Asn Gly Gly Pro Gly Pro 
            180                 185                 190         


Tyr Val Gly Gln Ala Gly Thr Ala Thr Leu Pro Arg Asn Phe His Tyr 
        195                 200                 205             


Pro Pro Asp Gly Tyr Ser Arg His Tyr Glu Asp Gly Tyr Pro Gly Gly 
    210                 215                 220                 


Ser Asp Asn Tyr Gly Ser Leu Ser Arg Val Thr Arg Ile Glu Glu Arg 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Glu Gly Tyr Arg Ala Pro Ser Arg Gln Asp Val 
                245                 250                 255     


Tyr Gly Pro Gln Pro Gln Val Arg Val Gly Gly Ser Ser Val Asp Leu 
            260                 265                 270         


His Arg Phe His Pro Glu Pro Tyr Gly Leu Glu Asp Asp Gln Arg Ser 
        275                 280                 285             


Met Gly Tyr Asp Asp Leu Asp Tyr Gly Met Met Ser Asp Tyr Gly Thr 
    290                 295                 300                 


Ala Arg Arg Thr Gly Thr Pro Ser Asp Pro Arg Arg Arg Leu Arg Ser 
305                 310                 315                 320 


Tyr Glu Asp Met Ile Gly Glu Glu Val Pro Ser Asp Gln Tyr Tyr Trp 
                325                 330                 335     


Ala Pro Leu Ala Gln His Glu Arg Gly Ser Leu Ala Ser Leu Asp Ser 
            340                 345                 350         


Leu Arg Lys Gly Gly Pro Pro Pro Pro Asn Trp Arg Gln Pro Glu Leu 
        355                 360                 365             


Pro Glu Val Ile Ala Met Leu Gly Phe Arg Leu Asp Ala Val Lys Ser 
    370                 375                 380                 


Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Tyr Arg Asn Asp Lys Val 
385                 390                 395                 400 


Lys Thr Asp Val Arg Lys Leu Lys Gly Ile Pro Val Leu Val Gly Leu 
                405                 410                 415     


Leu Asp His Pro Lys Lys Glu Val His Leu Gly Ala Cys Gly Ala Leu 
            420                 425                 430         


Lys Asn Ile Ser Phe Gly Arg Asp Gln Asp Asn Lys Ile Ala Ile Lys 
        435                 440                 445             


Asn Cys Asp Gly Val Pro Ala Leu Val Arg Leu Leu Arg Lys Ala Arg 
    450                 455                 460                 


Asp Met Asp Leu Thr Glu Val Ile Thr Gly Thr Leu Trp Asn Leu Ser 
465                 470                 475                 480 


Ser His Asp Ser Ile Lys Met Glu Ile Val Asp His Ala Leu His Ala 
                485                 490                 495     


Leu Thr Asp Glu Val Ile Ile Pro His Ser Gly Trp Glu Arg Glu Pro 
            500                 505                 510         


Asn Glu Asp Cys Lys Pro Arg His Ile Glu Trp Glu Ser Val Leu Thr 
        515                 520                 525             


Asn Thr Ala Gly Cys Leu Arg Asn Val Ser Ser Glu Arg Ser Glu Ala 
    530                 535                 540                 


Arg Arg Lys Leu Arg Glu Cys Asp Gly Leu Val Asp Ala Leu Ile Phe 
545                 550                 555                 560 


Ile Val Gln Ala Glu Ile Gly Gln Lys Asp Ser Asp Ser Lys Leu Val 
                565                 570                 575     


Glu Asn Cys Val Cys Leu Leu Arg Asn Leu Ser Tyr Gln Val His Arg 
            580                 585                 590         


Glu Ile Pro Gln Ala Glu Arg Tyr Gln Glu Ala Ala Pro Asn Val Ala 
        595                 600                 605             


Asn Asn Thr Gly Pro His Ala Ala Ser Cys Phe Gly Ala Lys Lys Gly 
    610                 615                 620                 


Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro Ile Glu Asp Pro Ala 
625                 630                 635                 640 


Asn Asp Thr Val Asp Phe Pro Lys Arg Thr Ser Pro Ala Arg Gly Tyr 
                645                 650                 655     


Glu Leu Leu Phe Gln Pro Glu Val Val Arg Ile Tyr Ile Ser Leu Leu 
            660                 665                 670         


Lys Glu Ser Lys Thr Pro Ala Ile Leu Glu Ala Ser Ala Gly Ala Ile 
        675                 680                 685             


Gln Asn Leu Cys Ala Gly Arg Trp Thr Tyr Gly Arg Tyr Ile Arg Ser 
    690                 695                 700                 


Ala Leu Arg Gln Glu Lys Ala Leu Ser Ala Ile Ala Asp Leu Leu Thr 
705                 710                 715                 720 


Asn Glu His Glu Arg Val Val Lys Ala Ala Ser Gly Ala Leu Arg Asn 
                725                 730                 735     


Leu Ala Val Asp Ala Arg Asn Lys Glu Leu Ile Gly Lys His Ala Ile 
            740                 745                 750         


Pro Asn Leu Val Lys Asn Leu Pro Gly Gly Gln Gln Asn Ser Ser Trp 
        755                 760                 765             


Asn Phe Ser Glu Asp Thr Val Ile Ser Ile Leu Asn Thr Ile Asn Glu 
    770                 775                 780                 


Val Ile Ala Glu Asn Leu Glu Ala Ala Lys Lys Leu Arg Glu Thr Gln 
785                 790                 795                 800 


Gly Ile Glu Lys Leu Val Leu Ile Asn Lys Ser Gly Asn Arg Ser Glu 
                805                 810                 815     


Lys Glu Val Arg Ala Ala Ala Leu Val Leu Gln Thr Ile Trp Gly Tyr 
            820                 825                 830         


Lys Glu Leu Arg Lys Pro Leu Glu Lys Glu Gly Trp Lys Lys Ser Asp 
        835                 840                 845             


Phe Gln Val Asn Leu Asn Asn Ala Ser Arg Ser Gln Ser Ser His Ser 
    850                 855                 860                 


Tyr Asp Asp Ser Thr Leu Pro Leu Ile Asp Arg Asn Gln Lys Ser Asp 
865                 870                 875                 880 


Lys Lys Pro Asp Arg Glu Glu Ile Gln Met Ser Asn Met Gly Ser Asn 
                885                 890                 895     


Thr Lys Ser Leu Asp Asn Asn Tyr Ser Thr Pro Asn Glu Arg Gly Asp 
            900                 905                 910         


His Asn Arg Thr Leu Asp Arg Ser Gly Asp Leu Gly Asp Met Glu Pro 
        915                 920                 925             


Leu Lys Gly Thr Thr Pro Leu Met Gln Asp Glu Gly Gln Glu Ser Leu 
    930                 935                 940                 


Glu Glu Glu Leu Asp Val Leu Val Leu Asp Asp Glu Gly Gly Gln Val 
945                 950                 955                 960 


Ser Tyr Pro Ser Met Gln Lys Ile 
                965             


<210>  2707
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNND2__Homo_sapiens__NP_001275644

<400>  2707

Met Ser Ser Met Ser Ser Ala Glu Glu Gln Phe Gln Trp Gln Ser Gln 
1               5                   10                  15      


Asp Gly Gln Lys Asp Ile Glu Asp Glu Leu Thr Thr Gly Leu Glu Leu 
            20                  25                  30          


Val Asp Ser Cys Ile Arg Ser Leu Gln Glu Ser Gly Ile Leu Asp Pro 
        35                  40                  45              


Gln Asp Tyr Ser Thr Gly Glu Arg Pro Ser Leu Leu Ser Gln Ser Ala 
    50                  55                  60                  


Leu Gln Leu Asn Ser Lys Pro Glu Gly Ser Phe Gln Tyr Pro Ala Ser 
65                  70                  75                  80  


Tyr His Ser Asn Gln Thr Leu Ala Leu Gly Glu Thr Thr Pro Ser Gln 
                85                  90                  95      


Leu Pro Ala Arg Gly Thr Gln Ala Arg Ala Thr Gly Gln Ser Phe Ser 
            100                 105                 110         


Gln Gly Thr Thr Ser Arg Ala Gly His Leu Ala Gly Pro Glu Pro Ala 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Arg Glu Pro Phe Ala Pro Ser Leu Gly 
    130                 135                 140                 


Ser Ala Phe His Leu Pro Asp Ala Pro Pro Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Leu Tyr Tyr Ser Ser Ser Thr Leu Pro Ala Pro Pro Arg Gly Gly Ser 
                165                 170                 175     


Pro Leu Ala Ala Pro Gln Gly Gly Ser Pro Thr Lys Leu Gln Arg Gly 
            180                 185                 190         


Gly Ser Ala Pro Glu Gly Ala Thr Tyr Ala Ala Pro Arg Gly Ser Ser 
        195                 200                 205             


Pro Lys Gln Ser Pro Ser Arg Leu Ala Lys Ser Tyr Ser Thr Ser Ser 
    210                 215                 220                 


Pro Ile Asn Ile Val Val Ser Ser Ala Gly Leu Ser Pro Ile Arg Val 
225                 230                 235                 240 


Thr Ser Pro Pro Thr Val Gln Ser Thr Ile Ser Ser Ser Pro Ile His 
                245                 250                 255     


Gln Leu Ser Ser Thr Ile Gly Thr Tyr Ala Thr Leu Ser Pro Thr Lys 
            260                 265                 270         


Arg Leu Val His Ala Ser Glu Gln Tyr Ser Lys His Ser Gln Glu Leu 
        275                 280                 285             


Tyr Ala Thr Ala Thr Leu Gln Arg Pro Gly Ser Leu Ala Ala Gly Ser 
    290                 295                 300                 


Arg Ala Ser Tyr Ser Ser Gln His Gly His Leu Gly Pro Glu Leu Arg 
305                 310                 315                 320 


Ala Leu Gln Ser Pro Glu His His Ile Asp Pro Ile Tyr Glu Asp Arg 
                325                 330                 335     


Val Tyr Gln Lys Pro Pro Met Arg Ser Leu Ser Gln Ser Gln Gly Asp 
            340                 345                 350         


Pro Leu Pro Pro Ala His Thr Gly Thr Tyr Arg Thr Ser Thr Ala Pro 
        355                 360                 365             


Ser Ser Pro Gly Val Asp Ser Val Pro Leu Gln Arg Thr Gly Ser Gln 
    370                 375                 380                 


His Gly Pro Gln Asn Ala Ala Ala Ala Thr Phe Gln Arg Ala Ser Tyr 
385                 390                 395                 400 


Ala Ala Gly Pro Ala Ser Asn Tyr Ala Asp Pro Tyr Arg Gln Leu Gln 
                405                 410                 415     


Tyr Cys Pro Ser Val Glu Ser Pro Tyr Ser Lys Ser Gly Pro Ala Leu 
            420                 425                 430         


Pro Pro Glu Gly Thr Leu Ala Arg Ser Pro Ser Ile Asp Ser Ile Gln 
        435                 440                 445             


Lys Asp Pro Arg Glu Phe Gly Trp Arg Asp Pro Glu Leu Pro Glu Val 
    450                 455                 460                 


Ile Gln Met Leu Gln His Gln Phe Pro Ser Val Gln Ser Asn Ala Ala 
465                 470                 475                 480 


Ala Tyr Leu Gln His Leu Cys Phe Gly Asp Asn Lys Ile Lys Ala Glu 
                485                 490                 495     


Ile Arg Arg Gln Gly Gly Ile Gln Leu Leu Val Asp Leu Leu Asp His 
            500                 505                 510         


Arg Met Thr Glu Val His Arg Ser Ala Cys Gly Ala Leu Arg Asn Leu 
        515                 520                 525             


Val Tyr Gly Lys Ala Asn Asp Asp Asn Lys Ile Ala Leu Lys Asn Cys 
    530                 535                 540                 


Gly Gly Ile Pro Ala Leu Val Arg Leu Leu Arg Lys Thr Thr Asp Leu 
545                 550                 555                 560 


Glu Ile Arg Glu Leu Val Thr Gly Val Leu Trp Asn Leu Ser Ser Cys 
                565                 570                 575     


Asp Ala Leu Lys Met Pro Ile Ile Gln Asp Ala Leu Ala Val Leu Thr 
            580                 585                 590         


Asn Ala Val Ile Ile Pro His Ser Gly Trp Glu Asn Ser Pro Leu Gln 
        595                 600                 605             


Asp Asp Arg Lys Ile Gln Leu His Ser Ser Gln Val Leu Arg Asn Ala 
    610                 615                 620                 


Thr Gly Cys Leu Arg Asn Val Ser Ser Ala Gly Glu Glu Ala Arg Arg 
625                 630                 635                 640 


Arg Met Arg Glu Cys Asp Gly Leu Thr Asp Ala Leu Leu Tyr Val Ile 
                645                 650                 655     


Gln Ser Ala Leu Gly Ser Ser Glu Ile Asp Ser Lys Thr Val Glu Asn 
            660                 665                 670         


Cys Val Cys Ile Leu Arg Asn Leu Ser Tyr Arg Leu Ala Ala Glu Thr 
        675                 680                 685             


Ser Gln Gly Gln His Met Gly Thr Asp Glu Leu Asp Gly Leu Leu Cys 
    690                 695                 700                 


Gly Glu Ala Asn Gly Lys Asp Ala Glu Ser Ser Gly Cys Trp Gly Lys 
705                 710                 715                 720 


Lys Lys Lys Lys Lys Lys Ser Gln Asp Gln Trp Asp Gly Val Gly Pro 
                725                 730                 735     


Leu Pro Asp Cys Ala Glu Pro Pro Lys Gly Ile Gln Met Leu Trp His 
            740                 745                 750         


Pro Ser Ile Val Lys Pro Tyr Leu Thr Leu Leu Ser Glu Cys Ser Asn 
        755                 760                 765             


Pro Asp Thr Leu Glu Gly Ala Ala Gly Ala Leu Gln Asn Leu Ala Ala 
    770                 775                 780                 


Gly Ser Trp Lys Trp Ser Val Tyr Ile Arg Ala Ala Val Arg Lys Glu 
785                 790                 795                 800 


Lys Gly Leu Pro Ile Leu Val Glu Leu Leu Arg Ile Asp Asn Asp Arg 
                805                 810                 815     


Val Val Cys Ala Val Ala Thr Ala Leu Arg Asn Met Ala Leu Asp Val 
            820                 825                 830         


Arg Asn Lys Glu Leu Ile Gly Lys Tyr Ala Met Arg Asp Leu Val His 
        835                 840                 845             


Arg Leu Pro Gly Gly Asn Asn Ser Asn Asn Thr Ala Ser Lys Ala Met 
    850                 855                 860                 


Ser Asp Asp Thr Val Thr Ala Val Cys Cys Thr Leu His Glu Val Ile 
865                 870                 875                 880 


Thr Lys Asn Met Glu Asn Ala Lys Ala Leu Arg Asp Ala Gly Gly Ile 
                885                 890                 895     


Glu Lys Leu Val Gly Ile Ser Lys Ser Lys Gly Asp Lys His Ser Pro 
            900                 905                 910         


Lys Val Val Lys Ala Ala Ser Gln Val Leu Asn Ser Met Trp Gln Tyr 
        915                 920                 925             


Arg Asp Leu Arg Ser Leu Tyr Lys Lys Asp Gly Trp Ser Gln Tyr His 
    930                 935                 940                 


Phe Val Ala Ser Ser Ser Thr Ile Glu Arg Asp Arg Gln Arg Pro Tyr 
945                 950                 955                 960 


Ser Ser Ser Arg Thr Pro Ser Ile Ser Pro Val Arg Val Ser Pro Asn 
                965                 970                 975     


Asn Arg Ser Ala Ser Ala Pro Ala Ser Pro Arg Glu Met Ile Ser Leu 
            980                 985                 990         


Lys Glu Arg Lys Thr Asp Tyr Glu  Cys Thr Gly Ser Asn  Ala Thr Tyr 
        995                 1000                 1005             


His Gly  Ala Lys Gly Glu His  Thr Ser Arg Lys Asp  Ala Met Thr 
    1010                 1015                 1020             


Ala Gln  Asn Thr Gly Ile Ser  Thr Leu Tyr Arg Asn  Ser Tyr Gly 
    1025                 1030                 1035             


Ala Pro  Ala Glu Asp Ile Lys  His Asn Gln Val Ser  Ala Gln Pro 
    1040                 1045                 1050             


Val Pro  Gln Glu Pro Ser Arg  Lys Asp Tyr Glu Thr  Tyr Gln Pro 
    1055                 1060                 1065             


Phe Gln  Asn Ser Thr Arg Asn  Tyr Asp Glu Ser Phe  Phe Glu Asp 
    1070                 1075                 1080             


Gln Val  His His Arg Pro Pro  Ala Ser Glu Tyr Thr  Met His Leu 
    1085                 1090                 1095             


Gly Leu  Lys Ser Thr Gly Asn  Tyr Val Asp Phe Tyr  Ser Ala Ala 
    1100                 1105                 1110             


Arg Pro  Tyr Ser Glu Leu Asn  Tyr Glu Thr Ser His  Tyr Pro Ala 
    1115                 1120                 1125             


Ser Pro  Asp Ser Trp Val 
    1130                 


<210>  2708
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTNS__Homo_sapiens__NP_001026851

<400>  2708

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro 
65                  70                  75                  80  


Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln 
                85                  90                  95      


Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg 
            100                 105                 110         


Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln 
        115                 120                 125             


Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro 
    130                 135                 140                 


Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe 
145                 150                 155                 160 


Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe 
                165                 170                 175     


Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu 
            180                 185                 190         


Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe 
        195                 200                 205             


Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys 
    210                 215                 220                 


Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe 
225                 230                 235                 240 


Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala 
                245                 250                 255     


Val Gly Val Thr Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile 
            260                 265                 270         


Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn 
        275                 280                 285             


Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu 
    290                 295                 300                 


Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser 
305                 310                 315                 320 


Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe 
                325                 330                 335     


Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln 
            340                 345                 350         


His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Leu Gln Ala Ala Arg Thr 
        355                 360                 365             


Gly Ser Gly Ser Arg Leu Arg Gln Asp Trp Ala Pro Ser Leu Gln Pro 
    370                 375                 380                 


Lys Ala Leu Pro Gln Thr Thr Ser Val Ser Ala Ser Ser Leu Lys Gly 
385                 390                 395                 400 


<210>  2709
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTPS1__Homo_sapiens__NP_001288166

<400>  2709

Met Pro Phe Ile Glu Ala Phe Arg Gln Phe Gln Phe Lys Val Lys Arg 
1               5                   10                  15      


Glu Asn Phe Cys Asn Ile His Val Ser Leu Val Pro Gln Pro Ser Ser 
            20                  25                  30          


Thr Gly Glu Gln Lys Thr Lys Pro Thr Gln Asn Ser Val Arg Glu Leu 
        35                  40                  45              


Arg Gly Leu Gly Leu Ser Pro Asp Leu Val Val Cys Arg Cys Ser Asn 
    50                  55                  60                  


Pro Leu Asp Thr Ser Val Lys Glu Lys Ile Ser Met Phe Cys His Val 
65                  70                  75                  80  


Glu Pro Glu Gln Val Ile Cys Val His Asp Val Ser Ser Ile Tyr Arg 
                85                  90                  95      


Val Pro Leu Leu Leu Glu Glu Gln Gly Val Val Asp Tyr Phe Leu Arg 
            100                 105                 110         


Arg Leu Asp Leu Pro Ile Glu Arg Gln Pro Arg Lys Met Leu Met Lys 
        115                 120                 125             


Trp Lys Glu Met Ala Asp Arg Tyr Asp Arg Leu Leu Glu Thr Cys Ser 
    130                 135                 140                 


Ile Ala Leu Val Gly Lys Tyr Thr Lys Phe Ser Asp Ser Tyr Ala Ser 
145                 150                 155                 160 


Val Ile Lys Ala Leu Glu His Ser Ala Leu Ala Ile Asn His Lys Leu 
                165                 170                 175     


Glu Ile Lys Tyr Ile Asp Ser Ala Asp Leu Glu Pro Ile Thr Ser Gln 
            180                 185                 190         


Glu Glu Pro Val Arg Tyr His Glu Ala Trp Gln Lys Leu Cys Ser Ala 
        195                 200                 205             


His Gly Val Leu Val Pro Gly Gly Phe Gly Val Arg Gly Thr Glu Gly 
    210                 215                 220                 


Lys Ile Gln Ala Ile Ala Trp Ala Arg Asn Gln Lys Lys Pro Phe Leu 
225                 230                 235                 240 


Gly Val Cys Leu Gly Met Gln Leu Ala Val Val Glu Phe Ser Arg Asn 
                245                 250                 255     


Val Leu Gly Trp Gln Asp Ala Asn Ser Thr Glu Phe Asp Pro Thr Thr 
            260                 265                 270         


Ser His Pro Val Val Val Asp Met Pro Glu His Asn Pro Gly Gln Met 
        275                 280                 285             


Gly Gly Thr Met Arg Leu Gly Lys Arg Arg Thr Leu Phe Gln Thr Lys 
    290                 295                 300                 


Asn Ser Val Met Arg Lys Leu Tyr Gly Asp Ala Asp Tyr Leu Glu Glu 
305                 310                 315                 320 


Arg His Arg His Arg Phe Glu Val Asn Pro Val Trp Lys Lys Cys Leu 
                325                 330                 335     


Glu Glu Gln Gly Leu Lys Phe Val Gly Gln Asp Val Glu Gly Glu Arg 
            340                 345                 350         


Met Glu Ile Val Glu Leu Glu Asp His Pro Phe Phe Val Gly Val Gln 
        355                 360                 365             


Tyr His Pro Glu Phe Leu Ser Arg Pro Ile Lys Pro Ser Pro Pro Tyr 
    370                 375                 380                 


Phe Gly Leu Leu Leu Ala Ser Val Gly Arg Leu Ser His Tyr Leu Gln 
385                 390                 395                 400 


Lys Gly Cys Arg Leu Ser Pro Arg Asp Thr Tyr Ser Asp Arg Ser Gly 
                405                 410                 415     


Ser Ser Ser Pro Asp Ser Glu Ile Thr Glu Leu Lys Phe Pro Ser Ile 
            420                 425                 430         


Asn His Asp 
        435 


<210>  2710
<211>  1173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTR9__Homo_sapiens__NP_055448

<400>  2710

Met Ser Arg Gly Ser Ile Glu Ile Pro Leu Arg Asp Thr Asp Glu Val 
1               5                   10                  15      


Ile Glu Leu Asp Phe Asp Gln Leu Pro Glu Gly Asp Glu Val Ile Ser 
            20                  25                  30          


Ile Leu Lys Gln Glu His Thr Gln Leu His Ile Trp Ile Ala Leu Ala 
        35                  40                  45              


Leu Glu Tyr Tyr Lys Gln Gly Lys Thr Glu Glu Phe Val Lys Leu Leu 
    50                  55                  60                  


Glu Ala Ala Arg Ile Asp Gly Asn Leu Asp Tyr Arg Asp His Glu Lys 
65                  70                  75                  80  


Asp Gln Met Thr Cys Leu Asp Thr Leu Ala Ala Tyr Tyr Val Gln Gln 
                85                  90                  95      


Ala Arg Lys Glu Lys Asn Lys Asp Asn Lys Lys Asp Leu Ile Thr Gln 
            100                 105                 110         


Ala Thr Leu Leu Tyr Thr Met Ala Asp Lys Ile Ile Met Tyr Asp Gln 
        115                 120                 125             


Asn His Leu Leu Gly Arg Ala Cys Phe Cys Leu Leu Glu Gly Asp Lys 
    130                 135                 140                 


Met Asp Gln Ala Asp Ala Gln Phe His Phe Val Leu Asn Gln Ser Pro 
145                 150                 155                 160 


Asn Asn Ile Pro Ala Leu Leu Gly Lys Ala Cys Ile Ser Phe Asn Lys 
                165                 170                 175     


Lys Asp Tyr Arg Gly Ala Leu Ala Tyr Tyr Lys Lys Ala Leu Arg Thr 
            180                 185                 190         


Asn Pro Gly Cys Pro Ala Glu Val Arg Leu Gly Met Gly His Cys Phe 
        195                 200                 205             


Val Lys Leu Asn Lys Leu Glu Lys Ala Arg Leu Ala Phe Ser Arg Ala 
    210                 215                 220                 


Leu Glu Leu Asn Ser Lys Cys Val Gly Ala Leu Val Gly Leu Ala Val 
225                 230                 235                 240 


Leu Glu Leu Asn Asn Lys Glu Ala Asp Ser Ile Lys Asn Gly Val Gln 
                245                 250                 255     


Leu Leu Ser Arg Ala Tyr Thr Ile Asp Pro Ser Asn Pro Met Val Leu 
            260                 265                 270         


Asn His Leu Ala Asn His Phe Phe Phe Lys Lys Asp Tyr Ser Lys Val 
        275                 280                 285             


Gln His Leu Ala Leu His Ala Phe His Asn Thr Glu Val Glu Ala Met 
    290                 295                 300                 


Gln Ala Glu Ser Cys Tyr Gln Leu Ala Arg Ser Phe His Val Gln Glu 
305                 310                 315                 320 


Asp Tyr Asp Gln Ala Phe Gln Tyr Tyr Tyr Gln Ala Thr Gln Phe Ala 
                325                 330                 335     


Ser Ser Ser Phe Val Leu Pro Phe Phe Gly Leu Gly Gln Met Tyr Ile 
            340                 345                 350         


Tyr Arg Gly Asp Lys Glu Asn Ala Ser Gln Cys Phe Glu Lys Val Leu 
        355                 360                 365             


Lys Ala Tyr Pro Asn Asn Tyr Glu Thr Met Lys Ile Leu Gly Ser Leu 
    370                 375                 380                 


Tyr Ala Ala Ser Glu Asp Gln Glu Lys Arg Asp Ile Ala Lys Gly His 
385                 390                 395                 400 


Leu Lys Lys Val Thr Glu Gln Tyr Pro Asp Asp Val Glu Ala Trp Ile 
                405                 410                 415     


Glu Leu Ala Gln Ile Leu Glu Gln Thr Asp Ile Gln Gly Ala Leu Ser 
            420                 425                 430         


Ala Tyr Gly Thr Ala Thr Arg Ile Leu Gln Glu Lys Val Gln Ala Asp 
        435                 440                 445             


Val Pro Pro Glu Ile Leu Asn Asn Val Gly Ala Leu His Phe Arg Leu 
    450                 455                 460                 


Gly Asn Leu Gly Glu Ala Lys Lys Tyr Phe Leu Ala Ser Leu Asp Arg 
465                 470                 475                 480 


Ala Lys Ala Glu Ala Glu His Asp Glu His Tyr Tyr Asn Ala Ile Ser 
                485                 490                 495     


Val Thr Thr Ser Tyr Asn Leu Ala Arg Leu Tyr Glu Ala Met Cys Glu 
            500                 505                 510         


Phe His Glu Ala Glu Lys Leu Tyr Lys Asn Ile Leu Arg Glu His Pro 
        515                 520                 525             


Asn Tyr Val Asp Cys Tyr Leu Arg Leu Gly Ala Met Ala Arg Asp Lys 
    530                 535                 540                 


Gly Asn Phe Tyr Glu Ala Ser Asp Trp Phe Lys Glu Ala Leu Gln Ile 
545                 550                 555                 560 


Asn Gln Asp His Pro Asp Ala Trp Ser Leu Ile Gly Asn Leu His Leu 
                565                 570                 575     


Ala Lys Gln Glu Trp Gly Pro Gly Gln Lys Lys Phe Glu Arg Ile Leu 
            580                 585                 590         


Lys Gln Pro Ser Thr Gln Ser Asp Thr Tyr Ser Met Leu Ala Leu Gly 
        595                 600                 605             


Asn Val Trp Leu Gln Thr Leu His Gln Pro Thr Arg Asp Arg Glu Lys 
    610                 615                 620                 


Glu Lys Arg His Gln Asp Arg Ala Leu Ala Ile Tyr Lys Gln Val Leu 
625                 630                 635                 640 


Arg Asn Asp Ala Lys Asn Leu Tyr Ala Ala Asn Gly Ile Gly Ala Val 
                645                 650                 655     


Leu Ala His Lys Gly Tyr Phe Arg Glu Ala Arg Asp Val Phe Ala Gln 
            660                 665                 670         


Val Arg Glu Ala Thr Ala Asp Ile Ser Asp Val Trp Leu Asn Leu Ala 
        675                 680                 685             


His Ile Tyr Val Glu Gln Lys Gln Tyr Ile Ser Ala Val Gln Met Tyr 
    690                 695                 700                 


Glu Asn Cys Leu Arg Lys Phe Tyr Lys His Gln Asn Thr Glu Val Val 
705                 710                 715                 720 


Leu Tyr Leu Ala Arg Ala Leu Phe Lys Cys Gly Lys Leu Gln Glu Cys 
                725                 730                 735     


Lys Gln Thr Leu Leu Lys Ala Arg His Val Ala Pro Ser Asp Thr Val 
            740                 745                 750         


Leu Met Phe Asn Val Ala Leu Val Leu Gln Arg Leu Ala Thr Ser Val 
        755                 760                 765             


Leu Lys Asp Glu Lys Ser Asn Leu Lys Glu Val Leu Asn Ala Val Lys 
    770                 775                 780                 


Glu Leu Glu Leu Ala His Arg Tyr Phe Ser Tyr Leu Ser Lys Val Gly 
785                 790                 795                 800 


Asp Lys Met Arg Phe Asp Leu Ala Leu Ala Ala Thr Glu Ala Arg Gln 
                805                 810                 815     


Cys Ser Asp Leu Leu Ser Gln Ala Gln Tyr His Val Ala Arg Ala Arg 
            820                 825                 830         


Lys Gln Asp Glu Glu Glu Arg Glu Leu Arg Ala Lys Gln Glu Gln Glu 
        835                 840                 845             


Lys Glu Leu Leu Arg Gln Lys Leu Leu Lys Glu Gln Glu Glu Lys Arg 
    850                 855                 860                 


Leu Arg Glu Lys Glu Glu Gln Lys Lys Leu Leu Glu Gln Arg Ala Gln 
865                 870                 875                 880 


Tyr Val Glu Lys Thr Lys Asn Ile Leu Met Phe Thr Gly Glu Thr Glu 
                885                 890                 895     


Ala Thr Lys Glu Lys Lys Arg Gly Gly Gly Gly Gly Arg Arg Ser Lys 
            900                 905                 910         


Lys Gly Gly Glu Phe Asp Glu Phe Val Asn Asp Asp Thr Asp Asp Asp 
        915                 920                 925             


Leu Pro Ile Ser Lys Lys Lys Lys Arg Arg Lys Gly Ser Gly Ser Glu 
    930                 935                 940                 


Gln Glu Gly Glu Asp Glu Glu Gly Gly Glu Arg Lys Lys Lys Lys Arg 
945                 950                 955                 960 


Arg Arg His Pro Lys Gly Glu Glu Gly Ser Asp Asp Asp Glu Thr Glu 
                965                 970                 975     


Asn Gly Pro Lys Pro Lys Lys Arg Arg Pro Pro Lys Ala Glu Lys Lys 
            980                 985                 990         


Lys Ala Pro Lys Pro Glu Arg Leu  Pro Pro Ser Met Lys  Gly Lys Ile 
        995                 1000                 1005             


Lys Ser  Lys Ala Ile Ile Ser  Ser Ser Asp Asp Ser  Ser Asp Glu 
    1010                 1015                 1020             


Asp Lys  Leu Lys Ile Ala Asp  Glu Gly His Pro Arg  Asn Ser Asn 
    1025                 1030                 1035             


Ser Asn  Ser Asp Ser Asp Glu  Asp Glu Gln Arg Lys  Lys Cys Ala 
    1040                 1045                 1050             


Ser Ser  Glu Ser Asp Ser Asp  Glu Asn Gln Asn Lys  Ser Gly Ser 
    1055                 1060                 1065             


Glu Ala  Gly Ser Pro Arg Arg  Pro Arg Arg Gln Arg  Ser Asp Gln 
    1070                 1075                 1080             


Asp Ser  Asp Ser Asp Gln Pro  Ser Arg Lys Arg Arg  Pro Ser Gly 
    1085                 1090                 1095             


Ser Glu  Gln Ser Asp Asn Glu  Ser Val Gln Ser Gly  Arg Ser His 
    1100                 1105                 1110             


Ser Gly  Val Ser Glu Asn Asp  Ser Arg Pro Ala Ser  Pro Ser Ala 
    1115                 1120                 1125             


Glu Ser  Asp His Glu Ser Glu  Arg Gly Ser Asp Asn  Glu Gly Ser 
    1130                 1135                 1140             


Gly Gln  Gly Ser Gly Asn Glu  Ser Glu Pro Glu Gly  Ser Asn Asn 
    1145                 1150                 1155             


Glu Ala  Ser Asp Arg Gly Ser  Glu His Gly Ser Asp  Asp Ser Asp 
    1160                 1165                 1170             


<210>  2711
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTRB1__Homo_sapiens__NP_001897

<400>  2711

Met Ala Ser Leu Trp Leu Leu Ser Cys Phe Ser Leu Val Gly Ala Ala 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Asp Thr Cys Ser Thr 
225                 230                 235                 240 


Ser Ser Pro Gly Val Tyr Ala Arg Val Thr Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  2712
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTRB2__Homo_sapiens__NP_001020371

<400>  2712

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Cys Gly Val Pro Ala Ile His Pro Val Leu Ser Gly Leu Ser 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asp Ala Val Pro Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Lys Thr Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Glu Asp Trp Val Val Thr Ala Ala His Cys Gly Val Arg Thr 
65                  70                  75                  80  


Ser Asp Val Val Val Ala Gly Glu Phe Asp Gln Gly Ser Asp Glu Glu 
                85                  90                  95      


Asn Ile Gln Val Leu Lys Ile Ala Lys Val Phe Lys Asn Pro Lys Phe 
            100                 105                 110         


Ser Ile Leu Thr Val Asn Asn Asp Ile Thr Leu Leu Lys Leu Ala Thr 
        115                 120                 125             


Pro Ala Arg Phe Ser Gln Thr Val Ser Ala Val Cys Leu Pro Ser Ala 
    130                 135                 140                 


Asp Asp Asp Phe Pro Ala Gly Thr Leu Cys Ala Thr Thr Gly Trp Gly 
145                 150                 155                 160 


Lys Thr Lys Tyr Asn Ala Asn Lys Thr Pro Asp Lys Leu Gln Gln Ala 
                165                 170                 175     


Ala Leu Pro Leu Leu Ser Asn Ala Glu Cys Lys Lys Ser Trp Gly Arg 
            180                 185                 190         


Arg Ile Thr Asp Val Met Ile Cys Ala Gly Ala Ser Gly Val Ser Ser 
        195                 200                 205             


Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Asp Gly Ala 
    210                 215                 220                 


Trp Thr Leu Val Gly Ile Val Ser Trp Gly Ser Arg Thr Cys Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Val Tyr Ala Arg Val Ala Lys Leu Ile Pro Trp Val 
                245                 250                 255     


Gln Lys Ile Leu Ala Ala Asn 
            260             


<210>  2713
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTRC__Homo_sapiens__XP_011538852

<400>  2713

Met Leu Gly Ile Thr Val Leu Ala Ala Leu Leu Ala Cys Ala Ser Ser 
1               5                   10                  15      


Cys Gly Val Pro Ser Phe Pro Pro Asn Leu Ser Ala Arg Val Val Gly 
            20                  25                  30          


Gly Glu Asp Ala Arg Pro His Ser Trp Pro Trp Gln Ile Ser Leu Gln 
        35                  40                  45              


Tyr Leu Lys Asn Asp Thr Trp Arg His Thr Cys Gly Gly Thr Leu Ile 
    50                  55                  60                  


Ala Ser Asn Phe Val Leu Thr Ala Ala His Cys Ile Ser Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Val Ala Val Gly Lys Asn Asn Leu Glu Val Glu Asp Glu 
                85                  90                  95      


Glu Gly Ser Leu Phe Val Gly Val Asp Thr Ile His Val His Lys Arg 
            100                 105                 110         


Trp Asn Ala Leu Leu Leu Arg Asn Asp Ile Ala Leu Ile Lys Leu Ala 
        115                 120                 125             


Glu His Val Glu Leu Ser Asp Thr Ile Gln Val Ala Cys Leu Pro Glu 
    130                 135                 140                 


Lys Asp Ser Leu Leu Pro Lys Asp Tyr Pro Cys Tyr Val Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Trp Arg Gly Leu Arg Trp Pro Thr Glu Leu Pro Val Gly 
                165                 170                 175     


Glu Arg Phe Leu Gly Gly Val Trp His Arg Gln Leu Trp Leu Pro Ala 
            180                 185                 190         


Gly Leu Gln His Pro Gln Glu Ala Gly Ser Leu His Pro Gly Val Arg 
        195                 200                 205             


Leu His Arg Leu Asp Gln Arg Glu Asn Ala Ala Val Ile Cys Cys Trp 
    210                 215                 220                 


Glu Arg Arg Gln Arg Val Pro Ala Thr Ala Ile Asn Phe Leu Leu Leu 
225                 230                 235                 240 


Gly Pro Pro Gly Ser Leu Ile Cys Ala Ala Ser Val Ala Ser Leu Leu 
                245                 250                 255     


Ser Gly Ala Ala Pro Phe His Thr Met Glu Pro Lys Arg Asp Pro Thr 
            260                 265                 270         


Gln Pro Val Ser Pro Thr Leu His 
        275                 280 


<210>  2714
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTRL__Homo_sapiens__NP_001898

<400>  2714

Met Leu Leu Leu Ser Leu Thr Leu Ser Leu Val Leu Leu Gly Ser Ser 
1               5                   10                  15      


Trp Gly Cys Gly Ile Pro Ala Ile Lys Pro Ala Leu Ser Phe Ser Gln 
            20                  25                  30          


Arg Ile Val Asn Gly Glu Asn Ala Val Leu Gly Ser Trp Pro Trp Gln 
        35                  40                  45              


Val Ser Leu Gln Asp Ser Ser Gly Phe His Phe Cys Gly Gly Ser Leu 
    50                  55                  60                  


Ile Ser Gln Ser Trp Val Val Thr Ala Ala His Cys Asn Val Ser Pro 
65                  70                  75                  80  


Gly Arg His Phe Val Val Leu Gly Glu Tyr Asp Arg Ser Ser Asn Ala 
                85                  90                  95      


Glu Pro Leu Gln Val Leu Ser Val Ser Arg Ala Ile Thr His Pro Ser 
            100                 105                 110         


Trp Asn Ser Thr Thr Met Asn Asn Asp Val Thr Leu Leu Lys Leu Ala 
        115                 120                 125             


Ser Pro Ala Gln Tyr Thr Thr Arg Ile Ser Pro Val Cys Leu Ala Ser 
    130                 135                 140                 


Ser Asn Glu Ala Leu Thr Glu Gly Leu Thr Cys Val Thr Thr Gly Trp 
145                 150                 155                 160 


Gly Arg Leu Ser Gly Val Gly Asn Val Thr Pro Ala His Leu Gln Gln 
                165                 170                 175     


Val Ala Leu Pro Leu Val Thr Val Asn Gln Cys Arg Gln Tyr Trp Gly 
            180                 185                 190         


Ser Ser Ile Thr Asp Ser Met Ile Cys Ala Gly Gly Ala Gly Ala Ser 
        195                 200                 205             


Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gln Lys Gly Asn 
    210                 215                 220                 


Thr Trp Val Leu Ile Gly Ile Val Ser Trp Gly Thr Lys Asn Cys Asn 
225                 230                 235                 240 


Val Arg Ala Pro Ala Val Tyr Thr Arg Val Ser Lys Phe Ser Thr Trp 
                245                 250                 255     


Ile Asn Gln Val Ile Ala Tyr Asn 
            260                 


<210>  2715
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSA__Homo_sapiens__NP_000299

<400>  2715

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn 
    210                 215                 220                 


Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala 
225                 230                 235                 240 


Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr 
                245                 250                 255     


His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu 
            260                 265                 270         


Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser 
        275                 280                 285             


Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro 
    290                 295                 300                 


Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly 
305                 310                 315                 320 


Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu 
                325                 330                 335     


Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr 
            340                 345                 350         


Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu 
        355                 360                 365             


Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val 
    370                 375                 380                 


Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu 
385                 390                 395                 400 


Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp 
                405                 410                 415     


Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser 
            420                 425                 430         


Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr 
        435                 440                 445             


Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His 
    450                 455                 460                 


Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp 
465                 470                 475                 480 


Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln 
                485                 490                 495     


Pro Tyr 
        


<210>  2716
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSB__Homo_sapiens__NP_680093

<400>  2716

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  2717
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSC__Homo_sapiens__NP_001107645

<400>  2717

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Thr Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Thr Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu Ala Met Asn Arg Arg Trp Gly 
    130                 135                 140     


<210>  2718
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSD__Homo_sapiens__NP_001900

<400>  2718

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  2719
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSE__Homo_sapiens__NP_001901

<400>  2719

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val 
145                 150                 155                 160 


Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe 
                165                 170                 175     


Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu 
            180                 185                 190         


Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn 
        195                 200                 205             


Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His 
225                 230                 235                 240 


Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp 
                245                 250                 255     


Gln Ile Ala Leu Asp Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys 
            260                 265                 270         


Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr 
        275                 280                 285             


Gly Pro Ser Asp Lys Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala 
    290                 295                 300                 


Pro Val Asp Gly Glu Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met 
305                 310                 315                 320 


Pro Asp Val Thr Phe Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro 
                325                 330                 335     


Thr Ala Tyr Thr Leu Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser 
            340                 345                 350         


Ser Gly Phe Gln Gly Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp 
        355                 360                 365             


Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg 
    370                 375                 380                 


Gly Asn Asn Arg Val Gly Leu Ala Pro Ala Val Pro 
385                 390                 395     


<210>  2720
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSF__Homo_sapiens__NP_003784

<400>  2720

Met Ala Pro Trp Leu Gln Leu Leu Ser Leu Leu Gly Leu Leu Pro Gly 
1               5                   10                  15      


Ala Val Ala Ala Pro Ala Gln Pro Arg Ala Ala Ser Phe Gln Ala Trp 
            20                  25                  30          


Gly Pro Pro Ser Pro Glu Leu Leu Ala Pro Thr Arg Phe Ala Leu Glu 
        35                  40                  45              


Met Phe Asn Arg Gly Arg Ala Ala Gly Thr Arg Ala Val Leu Gly Leu 
    50                  55                  60                  


Val Arg Gly Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Tyr Ser Leu 
65                  70                  75                  80  


Glu Ala Thr Leu Glu Glu Pro Pro Cys Asn Asp Pro Met Val Cys Arg 
                85                  90                  95      


Leu Pro Val Ser Lys Lys Thr Leu Leu Cys Ser Phe Gln Val Leu Asp 
            100                 105                 110         


Glu Leu Gly Arg His Val Leu Leu Arg Lys Asp Cys Gly Pro Val Asp 
        115                 120                 125             


Thr Lys Val Pro Gly Ala Gly Glu Pro Lys Ser Ala Phe Thr Gln Gly 
    130                 135                 140                 


Ser Ala Met Ile Ser Ser Leu Ser Gln Asn His Pro Asp Asn Arg Asn 
145                 150                 155                 160 


Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser 
                165                 170                 175     


Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile 
            180                 185                 190         


Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu 
        195                 200                 205             


Ser Val Phe Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu 
    210                 215                 220                 


Asp Arg Gly Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr 
225                 230                 235                 240 


Glu Glu Glu Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu 
                245                 250                 255     


Pro Gly Asn Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro 
            260                 265                 270         


Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp 
        275                 280                 285             


Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val 
    290                 295                 300                 


Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu 
305                 310                 315                 320 


Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly 
                325                 330                 335     


Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu 
            340                 345                 350         


Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe 
        355                 360                 365             


Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser 
    370                 375                 380                 


Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile 
385                 390                 395                 400 


Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile 
                405                 410                 415     


Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala 
            420                 425                 430         


Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe Trp Ala 
        435                 440                 445             


Ile Lys Asn Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr Tyr Tyr 
    450                 455                 460                 


Leu His Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala Ser Ser 
465                 470                 475                 480 


Ala Val Val Asp 
                


<210>  2721
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSG__Homo_sapiens__NP_001902

<400>  2721

Met Gln Pro Leu Leu Leu Leu Leu Ala Phe Leu Leu Pro Thr Gly Ala 
1               5                   10                  15      


Glu Ala Gly Glu Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln 
65                  70                  75                  80  


Arg Arg Glu Asn Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg 
                85                  90                  95      


His Pro Gln Tyr Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Ser Arg Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala 
        115                 120                 125             


Leu Pro Arg Ala Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val 
    130                 135                 140                 


Ala Gly Trp Gly Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg 
145                 150                 155                 160 


Glu Val Gln Leu Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe 
                165                 170                 175     


Gly Ser Tyr Asp Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu 
            180                 185                 190         


Arg Lys Ala Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn 
        195                 200                 205             


Asn Val Ala His Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro 
    210                 215                 220                 


Pro Glu Val Phe Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr 
225                 230                 235                 240 


Thr Met Arg Ser Phe Lys Leu Leu Asp Gln Met Glu Thr Pro Leu 
                245                 250                 255 


<210>  2722
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSH__Homo_sapiens__NP_004381

<400>  2722

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Thr Tyr Ser Thr 
        35                  40                  45              


Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys 
    50                  55                  60                  


Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys Met Ala Leu Asn 
65                  70                  75                  80  


Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp 
                85                  90                  95      


Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly 
            100                 105                 110         


Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe 
        115                 120                 125             


Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe 
    130                 135                 140                 


Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys 
145                 150                 155                 160 


Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe 
                165                 170                 175     


Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr 
            180                 185                 190         


Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln 
        195                 200                 205             


Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe 
    210                 215                 220                 


Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val 
225                 230                 235                 240 


Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr 
                245                 250                 255     


Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys 
            260                 265                 270         


His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr 
        275                 280                 285             


Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn 
305                 310                 315                 320 


Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val 
                325                 330                 335 


<210>  2723
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSL__Homo_sapiens__XP_005251773

<400>  2723

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  2724
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSO__Homo_sapiens__NP_001325

<400>  2724

Met Asp Val Arg Ala Leu Pro Trp Leu Pro Trp Leu Leu Trp Leu Leu 
1               5                   10                  15      


Cys Arg Gly Gly Gly Asp Ala Asp Ser Arg Ala Pro Phe Thr Pro Thr 
            20                  25                  30          


Trp Pro Arg Ser Arg Glu Arg Glu Ala Ala Ala Phe Arg Glu Ser Leu 
        35                  40                  45              


Asn Arg His Arg Tyr Leu Asn Ser Leu Phe Pro Ser Glu Asn Ser Thr 
    50                  55                  60                  


Ala Phe Tyr Gly Ile Asn Gln Phe Ser Tyr Leu Phe Pro Glu Glu Phe 
65                  70                  75                  80  


Lys Ala Ile Tyr Leu Arg Ser Lys Pro Ser Lys Phe Pro Arg Tyr Ser 
                85                  90                  95      


Ala Glu Val His Met Ser Ile Pro Asn Val Ser Leu Pro Leu Arg Phe 
            100                 105                 110         


Asp Trp Arg Asp Lys Gln Val Val Thr Gln Val Arg Asn Gln Gln Met 
        115                 120                 125             


Cys Gly Gly Cys Trp Ala Phe Ser Val Val Gly Ala Val Glu Ser Ala 
    130                 135                 140                 


Tyr Ala Ile Lys Gly Lys Pro Leu Glu Asp Leu Ser Val Gln Gln Val 
145                 150                 155                 160 


Ile Asp Cys Ser Tyr Asn Asn Tyr Gly Cys Asn Gly Gly Ser Thr Leu 
                165                 170                 175     


Asn Ala Leu Asn Trp Leu Asn Lys Met Gln Val Lys Leu Val Lys Asp 
            180                 185                 190         


Ser Glu Tyr Pro Phe Lys Ala Gln Asn Gly Leu Cys His Tyr Phe Ser 
        195                 200                 205             


Gly Ser His Ser Gly Phe Ser Ile Lys Gly Tyr Ser Ala Tyr Asp Phe 
    210                 215                 220                 


Ser Asp Gln Glu Asp Glu Met Ala Lys Ala Leu Leu Thr Phe Gly Pro 
225                 230                 235                 240 


Leu Val Val Ile Val Asp Ala Val Ser Trp Gln Asp Tyr Leu Gly Gly 
                245                 250                 255     


Ile Ile Gln His His Cys Ser Ser Gly Glu Ala Asn His Ala Val Leu 
            260                 265                 270         


Ile Thr Gly Phe Asp Lys Thr Gly Ser Thr Pro Tyr Trp Ile Val Arg 
        275                 280                 285             


Asn Ser Trp Gly Ser Ser Trp Gly Val Asp Gly Tyr Ala His Val Lys 
    290                 295                 300                 


Met Gly Ser Asn Val Cys Gly Ile Ala Asp Ser Val Ser Ser Ile Phe 
305                 310                 315                 320 


Val 
    


<210>  2725
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSV__Homo_sapiens__NP_001188504

<400>  2725

Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp 
            20                  25                  30          


Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly 
    50                  55                  60                  


Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg 
                85                  90                  95      


Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu 
            100                 105                 110         


Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln 
                165                 170                 175     


Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp 
        195                 200                 205             


Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val 
225                 230                 235                 240 


Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser 
                245                 250                 255     


Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser 
            260                 265                 270         


Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly 
        275                 280                 285             


Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn 
305                 310                 315                 320 


Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val 
                325                 330                 


<210>  2726
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSW__Homo_sapiens__NP_001326

<400>  2726

Met Ala Leu Thr Ala His Pro Ser Cys Leu Leu Ala Leu Leu Val Ala 
1               5                   10                  15      


Gly Leu Ala Gln Gly Ile Arg Gly Pro Leu Arg Ala Gln Asp Leu Gly 
            20                  25                  30          


Pro Gln Pro Leu Glu Leu Lys Glu Ala Phe Lys Leu Phe Gln Ile Gln 
        35                  40                  45              


Phe Asn Arg Ser Tyr Leu Ser Pro Glu Glu His Ala His Arg Leu Asp 
    50                  55                  60                  


Ile Phe Ala His Asn Leu Ala Gln Ala Gln Arg Leu Gln Glu Glu Asp 
65                  70                  75                  80  


Leu Gly Thr Ala Glu Phe Gly Val Thr Pro Phe Ser Asp Leu Thr Glu 
                85                  90                  95      


Glu Glu Phe Gly Gln Leu Tyr Gly Tyr Arg Arg Ala Ala Gly Gly Val 
            100                 105                 110         


Pro Ser Met Gly Arg Glu Ile Arg Ser Glu Glu Pro Glu Glu Ser Val 
        115                 120                 125             


Pro Phe Ser Cys Asp Trp Arg Lys Val Ala Gly Ala Ile Ser Pro Ile 
    130                 135                 140                 


Lys Asp Gln Lys Asn Cys Asn Cys Cys Trp Ala Met Ala Ala Ala Gly 
145                 150                 155                 160 


Asn Ile Glu Thr Leu Trp Arg Ile Ser Phe Trp Asp Phe Val Asp Val 
                165                 170                 175     


Ser Val Gln Glu Leu Leu Asp Cys Gly Arg Cys Gly Asp Gly Cys His 
            180                 185                 190         


Gly Gly Phe Val Trp Asp Ala Phe Ile Thr Val Leu Asn Asn Ser Gly 
        195                 200                 205             


Leu Ala Ser Glu Lys Asp Tyr Pro Phe Gln Gly Lys Val Arg Ala His 
    210                 215                 220                 


Arg Cys His Pro Lys Lys Tyr Gln Lys Val Ala Trp Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Met Leu Gln Asn Asn Glu His Arg Ile Ala Gln Tyr Leu Ala Thr 
                245                 250                 255     


Tyr Gly Pro Ile Thr Val Thr Ile Asn Met Lys Pro Leu Gln Leu Tyr 
            260                 265                 270         


Arg Lys Gly Val Ile Lys Ala Thr Pro Thr Thr Cys Asp Pro Gln Leu 
        275                 280                 285             


Val Asp His Ser Val Leu Leu Val Gly Phe Gly Ser Val Lys Ser Glu 
    290                 295                 300                 


Glu Gly Ile Trp Ala Glu Thr Val Ser Ser Gln Ser Gln Pro Gln Pro 
305                 310                 315                 320 


Pro His Pro Thr Pro Tyr Trp Ile Leu Lys Asn Ser Trp Gly Ala Gln 
                325                 330                 335     


Trp Gly Glu Lys Gly Tyr Phe Arg Leu His Arg Gly Ser Asn Thr Cys 
            340                 345                 350         


Gly Ile Thr Lys Phe Pro Leu Thr Ala Arg Val Gln Lys Pro Asp Met 
        355                 360                 365             


Lys Pro Arg Val Ser Cys Pro Pro 
    370                 375     


<210>  2727
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTSZ__Homo_sapiens__NP_001327

<400>  2727

Met Ala Arg Arg Gly Pro Gly Trp Arg Pro Leu Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Ala Gly Ala Ala Gln Gly Gly Leu Tyr Phe Arg Arg Gly Gln Thr 
            20                  25                  30          


Cys Tyr Arg Pro Leu Arg Gly Asp Gly Leu Ala Pro Leu Gly Arg Ser 
        35                  40                  45              


Thr Tyr Pro Arg Pro His Glu Tyr Leu Ser Pro Ala Asp Leu Pro Lys 
    50                  55                  60                  


Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala Ser Ile Thr 
65                  70                  75                  80  


Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp Ala His Ala 
                85                  90                  95      


Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg Lys Gly Ala 
            100                 105                 110         


Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp Cys Gly Asn 
        115                 120                 125             


Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp Asp Tyr Ala 
    130                 135                 140                 


His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr Gln Ala Lys 
145                 150                 155                 160 


Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys Asn Glu Phe 
                165                 170                 175     


Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg Val Gly Asp 
            180                 185                 190         


Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu Ile Tyr Ala 
        195                 200                 205             


Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg Leu Ala Asn 
    210                 215                 220                 


Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr Tyr Ile Asn 
225                 230                 235                 240 


His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly Thr Glu Tyr 
                245                 250                 255     


Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu Arg Gly Trp 
            260                 265                 270         


Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly Ala Arg Tyr 
        275                 280                 285             


Asn Leu Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro Ile Val 
    290                 295                 300             


<210>  2728
<211>  1663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTTNBP2__Homo_sapiens__NP_219499

<400>  2728

Met Ala Thr Asp Gly Ala Ser Cys Glu Pro Asp Leu Ser Arg Ala Pro 
1               5                   10                  15      


Glu Asp Ala Ala Gly Ala Ala Ala Glu Ala Ala Lys Lys Glu Phe Asp 
            20                  25                  30          


Val Asp Thr Leu Ser Lys Ser Glu Leu Arg Met Leu Leu Ser Val Met 
        35                  40                  45              


Glu Gly Glu Leu Glu Ala Arg Asp Leu Val Ile Glu Ala Leu Arg Ala 
    50                  55                  60                  


Arg Arg Lys Glu Val Phe Ile Gln Glu Arg Tyr Gly Arg Phe Asn Leu 
65                  70                  75                  80  


Asn Asp Pro Phe Leu Ala Leu Gln Arg Asp Tyr Glu Ala Gly Ala Gly 
                85                  90                  95      


Asp Lys Glu Lys Lys Pro Val Cys Thr Asn Pro Leu Ser Ile Leu Glu 
            100                 105                 110         


Ala Val Met Ala His Cys Lys Lys Met Gln Glu Arg Met Ser Ala Gln 
        115                 120                 125             


Leu Ala Ala Ala Glu Ser Arg Gln Lys Lys Leu Glu Met Glu Lys Leu 
    130                 135                 140                 


Gln Leu Gln Ala Leu Glu Gln Glu His Lys Lys Leu Ala Ala Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Arg Gly Lys Asn Lys Gln Val Val Leu Met Leu Val Lys 
                165                 170                 175     


Glu Cys Lys Gln Leu Ser Gly Lys Val Ile Glu Glu Ala Gln Lys Leu 
            180                 185                 190         


Glu Asp Val Met Ala Lys Leu Glu Glu Glu Lys Lys Lys Thr Asn Glu 
        195                 200                 205             


Leu Glu Glu Glu Leu Ser Ala Glu Lys Arg Arg Ser Thr Glu Met Glu 
    210                 215                 220                 


Ala Gln Met Glu Lys Gln Leu Ser Glu Phe Asp Thr Glu Arg Glu Gln 
225                 230                 235                 240 


Leu Arg Ala Lys Leu Asn Arg Glu Glu Ala His Thr Thr Asp Leu Lys 
                245                 250                 255     


Glu Glu Ile Asp Lys Met Arg Lys Met Ile Glu Gln Leu Lys Arg Gly 
            260                 265                 270         


Ser Asp Ser Lys Pro Ser Leu Ser Leu Pro Arg Lys Thr Lys Asp Arg 
        275                 280                 285             


Arg Leu Val Ser Ile Ser Val Gly Thr Glu Gly Thr Val Thr Arg Ser 
    290                 295                 300                 


Val Ala Cys Gln Thr Asp Leu Val Thr Glu Asn Ala Asp His Met Lys 
305                 310                 315                 320 


Lys Leu Pro Leu Thr Met Pro Val Lys Pro Ser Thr Gly Ser Pro Leu 
                325                 330                 335     


Val Ser Ala Asn Ala Lys Gly Ser Val Cys Thr Ser Ala Thr Met Ala 
            340                 345                 350         


Arg Pro Gly Ile Asp Arg Gln Ala Ser Tyr Gly Asp Leu Ile Gly Ala 
        355                 360                 365             


Ser Val Pro Ala Phe Pro Pro Pro Ser Ala Asn Lys Ile Glu Glu Asn 
    370                 375                 380                 


Gly Pro Ser Thr Gly Ser Thr Pro Asp Pro Thr Ser Ser Thr Pro Pro 
385                 390                 395                 400 


Leu Pro Ser Asn Ala Ala Pro Pro Thr Ala Gln Thr Pro Gly Ile Ala 
                405                 410                 415     


Pro Gln Asn Ser Gln Ala Pro Pro Met His Ser Leu His Ser Pro Cys 
            420                 425                 430         


Ala Asn Thr Ser Leu His Pro Gly Leu Asn Pro Arg Ile Gln Ala Ala 
        435                 440                 445             


Arg Phe Arg Phe Gln Gly Asn Ala Asn Asp Pro Asp Gln Asn Gly Asn 
    450                 455                 460                 


Thr Thr Gln Ser Pro Pro Ser Arg Asp Val Ser Pro Thr Ser Arg Asp 
465                 470                 475                 480 


Asn Leu Val Ala Lys Gln Leu Ala Arg Asn Thr Val Thr Gln Ala Leu 
                485                 490                 495     


Ser Arg Phe Thr Ser Pro Gln Ala Gly Ala Pro Ser Arg Pro Gly Val 
            500                 505                 510         


Pro Pro Thr Gly Asp Val Gly Thr His Pro Pro Val Gly Arg Thr Ser 
        515                 520                 525             


Leu Lys Thr His Gly Val Ala Arg Val Asp Arg Gly Asn Pro Pro Pro 
    530                 535                 540                 


Ile Pro Pro Lys Lys Pro Gly Leu Ser Gln Thr Pro Ser Pro Pro His 
545                 550                 555                 560 


Pro Gln Leu Lys Val Ile Ile Asp Ser Ser Arg Ala Ser Asn Thr Gly 
                565                 570                 575     


Ala Lys Val Asp Asn Lys Thr Val Ala Ser Thr Pro Ser Ser Leu Pro 
            580                 585                 590         


Gln Gly Asn Arg Val Ile Asn Glu Glu Asn Leu Pro Lys Ser Ser Ser 
        595                 600                 605             


Pro Gln Leu Pro Pro Lys Pro Ser Ile Asp Leu Thr Val Ala Pro Ala 
    610                 615                 620                 


Gly Cys Ala Val Ser Ala Leu Ala Thr Ser Gln Val Gly Ala Trp Pro 
625                 630                 635                 640 


Ala Ala Thr Pro Gly Leu Asn Gln Pro Ala Cys Ser Asp Ser Ser Leu 
                645                 650                 655     


Val Ile Pro Thr Thr Ile Ala Phe Cys Ser Ser Ile Asn Pro Val Ser 
            660                 665                 670         


Ala Ser Ser Cys Arg Pro Gly Ala Ser Asp Ser Leu Leu Val Thr Ala 
        675                 680                 685             


Ser Gly Trp Ser Pro Ser Leu Thr Pro Leu Leu Met Ser Gly Gly Pro 
    690                 695                 700                 


Ala Pro Leu Ala Gly Arg Pro Thr Leu Leu Gln Gln Ala Ala Ala Gln 
705                 710                 715                 720 


Gly Asn Val Thr Leu Leu Ser Met Leu Leu Asn Glu Glu Gly Leu Asp 
                725                 730                 735     


Ile Asn Tyr Ser Cys Glu Asp Gly His Ser Ala Leu Tyr Ser Ala Ala 
            740                 745                 750         


Lys Asn Gly His Thr Asp Cys Val Arg Leu Leu Leu Ser Ala Glu Ala 
        755                 760                 765             


Gln Val Asn Ala Ala Asp Lys Asn Gly Phe Thr Pro Leu Cys Ala Ala 
    770                 775                 780                 


Ala Ala Gln Gly His Phe Glu Cys Val Glu Leu Leu Ile Ser Tyr Asp 
785                 790                 795                 800 


Ala Asn Ile Asn His Ala Ala Asp Gly Gly Gln Thr Pro Leu Tyr Leu 
                805                 810                 815     


Ala Cys Lys Asn Gly Asn Lys Glu Cys Ile Lys Leu Leu Leu Glu Ala 
            820                 825                 830         


Gly Thr Asn Arg Ser Val Lys Thr Thr Asp Gly Trp Thr Pro Val His 
        835                 840                 845             


Ala Ala Val Asp Thr Gly Asn Val Asp Ser Leu Lys Leu Leu Met Tyr 
    850                 855                 860                 


His Arg Ile Pro Ala His Gly Asn Ser Phe Asn Glu Glu Glu Ser Glu 
865                 870                 875                 880 


Ser Ser Val Phe Asp Leu Asp Gly Gly Glu Glu Ser Pro Glu Gly Ile 
                885                 890                 895     


Ser Lys Pro Val Val Pro Ala Asp Leu Ile Asn His Ala Asn Arg Glu 
            900                 905                 910         


Gly Trp Thr Ala Ala His Ile Ala Ala Ser Lys Gly Phe Lys Asn Cys 
        915                 920                 925             


Leu Glu Ile Leu Cys Arg His Gly Gly Leu Glu Pro Glu Arg Arg Asp 
    930                 935                 940                 


Lys Cys Asn Arg Thr Val His Asp Val Ala Thr Asp Asp Cys Lys His 
945                 950                 955                 960 


Leu Leu Glu Asn Leu Asn Ala Leu Lys Ile Pro Leu Arg Ile Ser Val 
                965                 970                 975     


Gly Glu Ile Glu Pro Ser Asn Tyr Gly Ser Asp Asp Leu Glu Cys Glu 
            980                 985                 990         


Asn Thr Ile Cys Ala Leu Asn Ile  Arg Lys Gln Thr Ser  Trp Asp Asp 
        995                 1000                 1005             


Phe Ser  Lys Ala Val Ser Gln  Ala Leu Thr Asn His  Phe Gln Ala 
    1010                 1015                 1020             


Ile Ser  Ser Asp Gly Trp Trp  Ser Leu Glu Asp Val  Thr Cys Asn 
    1025                 1030                 1035             


Asn Thr  Thr Asp Ser Asn Ile  Gly Leu Ser Ala Arg  Ser Ile Arg 
    1040                 1045                 1050             


Ser Ile  Thr Leu Gly Asn Val  Pro Trp Ser Val Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ala Gln  Ser Pro Trp Asp Phe  Met Arg Lys Asn Lys  Ala Glu His 
    1070                 1075                 1080             


Ile Thr  Val Leu Leu Ser Gly  Pro Gln Glu Gly Cys  Leu Ser Ser 
    1085                 1090                 1095             


Val Thr  Tyr Ala Ser Met Ile  Pro Leu Gln Met Met  Gln Asn Tyr 
    1100                 1105                 1110             


Leu Arg  Leu Val Glu Gln Tyr  His Asn Val Ile Phe  His Gly Pro 
    1115                 1120                 1125             


Glu Gly  Ser Leu Gln Asp Tyr  Ile Val His Gln Leu  Ala Leu Cys 
    1130                 1135                 1140             


Leu Lys  His Arg Gln Met Ala  Ala Gly Phe Ser Cys  Glu Ile Val 
    1145                 1150                 1155             


Arg Ala  Glu Val Asp Ala Gly  Phe Ser Lys Glu Gln  Leu Leu Asp 
    1160                 1165                 1170             


Leu Phe  Ile Ser Ser Ala Cys  Leu Ile Pro Val Lys  Gln Ser Pro 
    1175                 1180                 1185             


Ser Lys  Lys Lys Ile Ile Ile  Ile Leu Glu Asn Leu  Glu Lys Ser 
    1190                 1195                 1200             


Ser Leu  Ser Glu Leu Leu Arg  Asp Phe Leu Ala Pro  Leu Glu Asn 
    1205                 1210                 1215             


Arg Ser  Thr Glu Ser Pro Cys  Thr Phe Gln Lys Gly  Asn Gly Leu 
    1220                 1225                 1230             


Ser Glu  Cys Tyr Tyr Phe His  Glu Asn Cys Phe Leu  Met Gly Thr 
    1235                 1240                 1245             


Ile Ala  Lys Ala Cys Leu Gln  Gly Ser Asp Leu Leu  Val Gln Gln 
    1250                 1255                 1260             


His Phe  Arg Trp Val Gln Leu  Arg Trp Asp Gly Glu  Pro Met Gln 
    1265                 1270                 1275             


Gly Leu  Leu Gln Arg Phe Leu  Arg Arg Lys Val Val  Asn Lys Phe 
    1280                 1285                 1290             


Lys Gly  Gln Ala Pro Ser Pro  Cys Asp Pro Val Cys  Lys Ile Val 
    1295                 1300                 1305             


Asp Trp  Ala Leu Ser Val Trp  Arg Gln Leu Asn Ser  Cys Leu Ala 
    1310                 1315                 1320             


Arg Leu  Gly Thr Pro Glu Ala  Leu Leu Gly Pro Lys  Tyr Phe Leu 
    1325                 1330                 1335             


Ser Cys  Pro Val Val Pro Gly  His Ala Gln Val Thr  Val Lys Trp 
    1340                 1345                 1350             


Met Ser  Lys Leu Trp Asn Gly  Val Ile Ala Pro Arg  Val Gln Glu 
    1355                 1360                 1365             


Ala Ile  Leu Ser Arg Ala Ser  Val Lys Arg Gln Pro  Gly Phe Gly 
    1370                 1375                 1380             


Gln Thr  Thr Ala Lys Arg His  Pro Ser Gln Gly Gln  Gln Ala Val 
    1385                 1390                 1395             


Val Lys  Ala Ala Leu Ser Ile  Leu Leu Asn Lys Ala  Val Leu His 
    1400                 1405                 1410             


Gly Cys  Pro Leu Pro Arg Ala  Glu Leu Asp Gln His  Thr Ala Asp 
    1415                 1420                 1425             


Phe Lys  Gly Gly Ser Phe Pro  Leu Ser Ile Val Ser  Ser Tyr Asn 
    1430                 1435                 1440             


Thr Cys  Asn Lys Lys Lys Gly  Glu Ser Gly Ala Trp  Arg Lys Val 
    1445                 1450                 1455             


Asn Thr  Ser Pro Arg Arg Lys  Ser Gly Arg Phe Ser  Leu Pro Thr 
    1460                 1465                 1470             


Trp Asn  Lys Pro Asp Leu Ser  Thr Glu Gly Met Lys  Asn Lys Thr 
    1475                 1480                 1485             


Ile Ser  Gln Leu Asn Cys Asn  Arg Asn Ala Ser Leu  Ser Lys Gln 
    1490                 1495                 1500             


Lys Ser  Leu Glu Asn Asp Leu  Ser Leu Thr Leu Asn  Leu Asp Gln 
    1505                 1510                 1515             


Arg Leu  Ser Leu Gly Ser Asp  Asp Glu Ala Asp Leu  Val Lys Glu 
    1520                 1525                 1530             


Leu Gln  Ser Met Cys Ser Ser  Lys Ser Glu Ser Asp  Ile Ser Lys 
    1535                 1540                 1545             


Ile Ala  Asp Ser Arg Asp Asp  Leu Arg Met Phe Asp  Ser Ser Gly 
    1550                 1555                 1560             


Asn Asn  Pro Val Leu Ser Ala  Thr Ile Asn Asn Leu  Arg Met Pro 
    1565                 1570                 1575             


Val Ser  Gln Lys Glu Val Ser  Pro Leu Ser Ser His  Gln Thr Thr 
    1580                 1585                 1590             


Glu Cys  Ser Asn Ser Lys Ser  Lys Thr Glu Leu Gly  Val Ser Arg 
    1595                 1600                 1605             


Val Lys  Ser Phe Leu Pro Val  Pro Arg Ser Lys Val  Thr Gln Cys 
    1610                 1615                 1620             


Ser Gln  Asn Thr Lys Arg Ser  Ser Ser Ser Ser Asn  Thr Arg Gln 
    1625                 1630                 1635             


Ile Glu  Ile Asn Asn Asn Ser  Lys Glu Val Asn Trp  Asn Leu His 
    1640                 1645                 1650             


Lys Asn  Glu His Leu Glu Lys  Pro Asn Lys 
    1655                 1660             


<210>  2729
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTTN__Homo_sapiens__NP_001171669

<400>  2729

Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
1               5                   10                  15      


Ala Gly Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val 
            20                  25                  30          


Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly 
        35                  40                  45              


His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
    50                  55                  60                  


Glu His Gln Thr Leu Lys Glu Lys Glu Leu Glu Thr Gly Pro Lys Ala 
65                  70                  75                  80  


Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                85                  90                  95      


Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
            100                 105                 110         


Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
        115                 120                 125             


Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
    130                 135                 140                 


Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
145                 150                 155                 160 


Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                165                 170                 175     


Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
            180                 185                 190         


Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
        195                 200                 205             


Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser 
    210                 215                 220                 


Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Thr 
225                 230                 235                 240 


Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                245                 250                 255     


Gln Leu His Glu Ser Gln Lys Asp Tyr Ser Lys Gly Phe Gly Gly Lys 
            260                 265                 270         


Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn Ala Ser Thr Phe Glu 
        275                 280                 285             


Asp Val Thr Gln Val Ser Ser Ala Tyr Gln Lys Thr Val Pro Val Glu 
    290                 295                 300                 


Ala Val Thr Ser Lys Thr Ser Asn Ile Arg Ala Asn Phe Glu Asn Leu 
305                 310                 315                 320 


Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys Ala Glu Ala Glu Arg 
                325                 330                 335     


Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln Glu Glu Ala Arg Arg 
            340                 345                 350         


Lys Leu Glu Glu Gln Ala Arg Ala Lys Thr Gln Thr Pro Pro Val Ser 
        355                 360                 365             


Pro Ala Pro Gln Pro Thr Glu Glu Arg Leu Pro Ser Ser Pro Val Tyr 
    370                 375                 380                 


Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser Tyr Arg Gly Pro Val 
385                 390                 395                 400 


Ser Gly Thr Glu Pro Glu Pro Val Tyr Ser Met Glu Ala Ala Asp Tyr 
                405                 410                 415     


Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr Ala Thr Glu Ala Val 
            420                 425                 430         


Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro Ala Glu Asp Ser Thr 
        435                 440                 445             


Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Thr Ala Val Ala Leu Tyr 
    450                 455                 460                 


Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser Phe Asp Pro Asp Asp 
465                 470                 475                 480 


Ile Ile Thr Asn Ile Glu Met Ile Asp Asp Gly Trp Trp Arg Gly Val 
                485                 490                 495     


Cys Lys Gly Arg Phe Arg Glu Leu Ala Phe Ser Cys Val Arg Val Ala 
            500                 505                 510         


Leu Val Pro Ile Lys Cys Ser Arg Asp Leu Pro Gly Gln Ala Arg Gly 
        515                 520                 525             


Leu Arg Ser Ala Leu Trp Arg Val Gly Arg Lys Asp Cys Pro Arg Arg 
    530                 535                 540                 


Gly Ala Ser Ser Arg Val Ser Leu Leu Gly Arg Arg Gly Leu Gly Leu 
545                 550                 555                 560 


Met Glu Val Asn Pro Glu Leu Ser His Pro Glu His Arg Ser Cys His 
                565                 570                 575     


Val Arg Trp Glu Ile Cys Leu Cys His Thr Val Thr Ala Arg Arg Ile 
            580                 585                 590         


Arg Lys Leu Ile Ser Phe Leu Arg Ser Arg Glu Ala Gly Pro Val Pro 
        595                 600                 605             


Ser Cys Ser Gln Val Gly Gly Val Ser Phe Gln Lys Val Thr Trp Lys 
    610                 615                 620                 


Cys Leu Gly Thr Trp Val Pro Glu Cys Pro 
625                 630                 


<210>  2730
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTU1__Homo_sapiens__NP_660275

<400>  2730

Met Pro Ala Pro Pro Cys Ala Ser Cys His Ala Ala Arg Ala Ala Leu 
1               5                   10                  15      


Arg Arg Pro Leu Ser Gly Gln Ala Leu Cys Gly Ala Cys Phe Cys Ala 
            20                  25                  30          


Ala Phe Glu Ala Glu Val Leu His Thr Val Leu Ala Gly Arg Leu Leu 
        35                  40                  45              


Pro Pro Gly Ala Val Val Ala Val Gly Ala Ser Gly Gly Lys Asp Ser 
    50                  55                  60                  


Thr Val Leu Ala His Val Leu Arg Ala Leu Ala Pro Arg Leu Gly Ile 
65                  70                  75                  80  


Ser Leu Gln Leu Val Ala Val Asp Glu Gly Ile Gly Gly Tyr Arg Asp 
                85                  90                  95      


Ala Ala Leu Ala Ala Val Arg Arg Gln Ala Ala Arg Trp Glu Leu Pro 
            100                 105                 110         


Leu Thr Val Val Ala Tyr Glu Asp Leu Phe Gly Gly Trp Thr Met Asp 
        115                 120                 125             


Ala Val Ala Arg Ser Thr Ala Gly Ser Gly Arg Ser Arg Ser Cys Cys 
    130                 135                 140                 


Thr Phe Cys Gly Val Leu Arg Arg Arg Ala Leu Glu Glu Gly Ala Arg 
145                 150                 155                 160 


Arg Val Gly Ala Thr His Ile Val Thr Gly His Asn Ala Asp Asp Met 
                165                 170                 175     


Ala Glu Thr Val Leu Met Asn Phe Leu Arg Gly Asp Ala Gly Arg Leu 
            180                 185                 190         


Ala Arg Gly Gly Gly Leu Gly Ser Pro Gly Glu Gly Gly Ala Leu Pro 
        195                 200                 205             


Arg Cys Arg Pro Leu Gln Phe Ala Ser Gln Lys Glu Val Val Leu Tyr 
    210                 215                 220                 


Ala His Phe Arg Arg Leu Asp Tyr Phe Ser Glu Glu Cys Val Tyr Ala 
225                 230                 235                 240 


Pro Glu Ala Phe Arg Gly His Ala Arg Asp Leu Leu Lys Arg Leu Glu 
                245                 250                 255     


Ala Ala Arg Pro Ser Ala Val Leu Asp Leu Val His Ser Ala Glu Arg 
            260                 265                 270         


Leu Ala Leu Ala Pro Ala Ala Arg Pro Pro Arg Pro Gly Ala Cys Ser 
        275                 280                 285             


Arg Cys Gly Ala Leu Ala Ser Arg Ala Leu Cys Gln Ala Cys Ala Leu 
    290                 295                 300                 


Leu Asp Gly Leu Asn Arg Gly Arg Pro Arg Leu Ala Ile Gly Lys Gly 
305                 310                 315                 320 


Arg Arg Gly Leu Asp Glu Glu Ala Thr Pro Gly Thr Pro Gly Asp Pro 
                325                 330                 335     


Ala Arg Pro Pro Ala Ser Lys Ala Val Pro Thr Phe 
            340                 345             


<210>  2731
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTXN3__Homo_sapiens__NP_001041717

<400>  2731

Met Asp Gly Gly Gln Pro Ile Pro Ser Ser Leu Val Pro Leu Gly Asn 
1               5                   10                  15      


Glu Ser Ala Asp Ser Ser Met Ser Leu Glu Gln Lys Met Thr Phe Val 
            20                  25                  30          


Phe Val Ile Leu Leu Phe Ile Phe Leu Gly Ile Leu Ile Val Arg Cys 
        35                  40                  45              


Phe Arg Ile Leu Leu Asp Pro Tyr Arg Ser Met Pro Thr Ser Thr Trp 
    50                  55                  60                  


Ala Asp Gly Leu Glu Gly Leu Glu Lys Gly Gln Phe Asp His Ala Leu 
65                  70                  75                  80  


Ala 
    


<210>  2732
<211>  3623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUBN__Homo_sapiens__NP_001072

<400>  2732

Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ile Phe Ala Glu Val Asn Gly Glu Ala Gly Glu Leu Glu Leu Gln Arg 
            20                  25                  30          


Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg 
        35                  40                  45              


Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg 
    50                  55                  60                  


Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu 
65                  70                  75                  80  


Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys 
                85                  90                  95      


Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln 
            100                 105                 110         


Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln 
        115                 120                 125             


Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly 
    130                 135                 140                 


Gly Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro 
145                 150                 155                 160 


Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile 
                165                 170                 175     


Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn 
            180                 185                 190         


Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro 
        195                 200                 205             


Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg 
    210                 215                 220                 


Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu 
225                 230                 235                 240 


Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Phe Ser Pro Asn 
                245                 250                 255     


Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly 
            260                 265                 270         


Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr 
        275                 280                 285             


Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu 
    290                 295                 300                 


Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro 
305                 310                 315                 320 


Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys 
                325                 330                 335     


Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile 
            340                 345                 350         


Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser 
        355                 360                 365             


Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly 
    370                 375                 380                 


Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu 
385                 390                 395                 400 


Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr 
                405                 410                 415     


Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn 
            420                 425                 430         


Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val 
        435                 440                 445             


Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly 
    450                 455                 460                 


Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly 
465                 470                 475                 480 


Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His 
                485                 490                 495     


Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu 
            500                 505                 510         


Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro 
        515                 520                 525             


His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln 
    530                 535                 540                 


Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser 
545                 550                 555                 560 


Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly 
                565                 570                 575     


Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly 
            580                 585                 590         


Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly 
        595                 600                 605             


Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro 
    610                 615                 620                 


Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His 
625                 630                 635                 640 


Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr 
                645                 650                 655     


Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro 
            660                 665                 670         


Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser 
        675                 680                 685             


Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser 
    690                 695                 700                 


Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe 
705                 710                 715                 720 


Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr 
                725                 730                 735     


Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His 
            740                 745                 750         


Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val 
        755                 760                 765             


Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile 
    770                 775                 780                 


Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile 
785                 790                 795                 800 


Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala 
                805                 810                 815     


Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe 
            820                 825                 830         


Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln 
        835                 840                 845             


Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly 
    850                 855                 860                 


Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser 
865                 870                 875                 880 


Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro 
                885                 890                 895     


Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys 
            900                 905                 910         


Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu 
        915                 920                 925             


Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln 
    930                 935                 940                 


Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp 
945                 950                 955                 960 


His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr 
                965                 970                 975     


Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val 
            980                 985                 990         


Tyr Asp Thr Asp Ser Glu Thr Ser  Leu Gly Arg Tyr Cys  Gly Lys Ser 
        995                 1000                 1005             


Ile Pro  Pro Ser Leu Thr Ser  Ser Gly Asn Ser Leu  Met Leu Val 
    1010                 1015                 1020             


Phe Val  Thr Asp Ser Asp Leu  Ala Tyr Glu Gly Phe  Leu Ile Asn 
    1025                 1030                 1035             


Tyr Glu  Ala Ile Ser Ala Ala  Thr Ala Cys Leu Gln  Asp Tyr Thr 
    1040                 1045                 1050             


Asp Asp  Leu Gly Thr Phe Thr  Ser Pro Asn Phe Pro  Asn Asn Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Trp Glu Cys Ile  Tyr Arg Ile Thr Val  Arg Thr Gly 
    1070                 1075                 1080             


Gln Leu  Ile Ala Val His Phe  Thr Asn Phe Ser Leu  Glu Glu Ala 
    1085                 1090                 1095             


Ile Gly  Asn Tyr Tyr Thr Asp  Phe Leu Glu Ile Arg  Asp Gly Gly 
    1100                 1105                 1110             


Tyr Glu  Lys Ser Pro Leu Leu  Gly Ile Phe Tyr Gly  Ser Asn Leu 
    1115                 1120                 1125             


Pro Pro  Thr Ile Ile Ser His  Ser Asn Lys Leu Trp  Leu Lys Phe 
    1130                 1135                 1140             


Lys Ser  Asp Gln Ile Asp Thr  Arg Ser Gly Phe Ser  Ala Tyr Trp 
    1145                 1150                 1155             


Asp Gly  Ser Ser Thr Gly Cys  Gly Gly Asn Leu Thr  Thr Ser Ser 
    1160                 1165                 1170             


Gly Thr  Phe Ile Ser Pro Asn  Tyr Pro Met Pro Tyr  Tyr His Ser 
    1175                 1180                 1185             


Ser Glu  Cys Tyr Trp Trp Leu  Lys Ser Ser His Gly  Ser Ala Phe 
    1190                 1195                 1200             


Glu Leu  Glu Phe Lys Asp Phe  His Leu Glu His His  Pro Asn Cys 
    1205                 1210                 1215             


Thr Leu  Asp Tyr Leu Ala Val  Tyr Asp Gly Pro Ser  Ser Asn Ser 
    1220                 1225                 1230             


His Leu  Leu Thr Gln Leu Cys  Gly Asp Glu Lys Pro  Pro Leu Ile 
    1235                 1240                 1245             


Arg Ser  Ser Gly Asp Ser Met  Phe Ile Lys Leu Arg  Thr Asp Glu 
    1250                 1255                 1260             


Gly Gln  Gln Gly Arg Gly Phe  Lys Ala Glu Tyr Arg  Gln Thr Cys 
    1265                 1270                 1275             


Glu Asn  Val Val Ile Val Asn  Gln Thr Tyr Gly Ile  Leu Glu Ser 
    1280                 1285                 1290             


Ile Gly  Tyr Pro Asn Pro Tyr  Ser Glu Asn Gln His  Cys Asn Trp 
    1295                 1300                 1305             


Thr Ile  Arg Ala Thr Thr Gly  Asn Thr Val Asn Tyr  Thr Phe Leu 
    1310                 1315                 1320             


Ala Phe  Asp Leu Glu His His  Ile Asn Cys Ser Thr  Asp Tyr Leu 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Gly Pro Arg  Gln Met Gly Arg Tyr  Cys Gly Val 
    1340                 1345                 1350             


Asp Leu  Pro Pro Pro Gly Ser  Thr Thr Ser Ser Lys  Leu Gln Val 
    1355                 1360                 1365             


Leu Leu  Leu Thr Asp Gly Val  Gly Arg Arg Glu Lys  Gly Phe Gln 
    1370                 1375                 1380             


Met Gln  Trp Phe Val Tyr Gly  Cys Gly Gly Glu Leu  Ser Gly Ala 
    1385                 1390                 1395             


Thr Gly  Ser Phe Ser Ser Pro  Gly Phe Pro Asn Arg  Tyr Pro Pro 
    1400                 1405                 1410             


Asn Lys  Glu Cys Ile Trp Tyr  Ile Arg Thr Asp Pro  Gly Ser Ser 
    1415                 1420                 1425             


Ile Gln  Leu Thr Ile His Asp  Phe Asp Val Glu Tyr  His Ser Arg 
    1430                 1435                 1440             


Cys Asn  Phe Asp Val Leu Glu  Ile Tyr Gly Gly Pro  Asp Phe His 
    1445                 1450                 1455             


Ser Pro  Arg Ile Ala Gln Leu  Cys Thr Gln Arg Ser  Pro Glu Asn 
    1460                 1465                 1470             


Pro Met  Gln Val Ser Ser Thr  Gly Asn Glu Leu Ala  Ile Arg Phe 
    1475                 1480                 1485             


Lys Thr  Asp Leu Ser Ile Asn  Gly Arg Gly Phe Asn  Ala Ser Trp 
    1490                 1495                 1500             


Gln Ala  Val Thr Gly Gly Cys  Gly Gly Ile Phe Gln  Ala Pro Ser 
    1505                 1510                 1515             


Gly Glu  Ile His Ser Pro Asn  Tyr Pro Ser Pro Tyr  Arg Ser Asn 
    1520                 1525                 1530             


Thr Asp  Cys Ser Trp Val Ile  Arg Val Asp Arg Asn  His Arg Val 
    1535                 1540                 1545             


Leu Leu  Asn Phe Thr Asp Phe  Asp Leu Glu Pro Gln  Asp Ser Cys 
    1550                 1555                 1560             


Ile Met  Ala Tyr Asp Gly Leu  Ser Ser Thr Met Ser  Arg Leu Ala 
    1565                 1570                 1575             


Arg Thr  Cys Gly Arg Glu Gln  Leu Ala Asn Pro Ile  Val Ser Ser 
    1580                 1585                 1590             


Gly Asn  Ser Leu Phe Leu Arg  Phe Gln Ser Gly Pro  Ser Arg Gln 
    1595                 1600                 1605             


Asn Arg  Gly Phe Arg Ala Gln  Phe Arg Gln Ala Cys  Gly Gly His 
    1610                 1615                 1620             


Ile Leu  Thr Ser Ser Phe Asp  Thr Val Ser Ser Pro  Arg Phe Pro 
    1625                 1630                 1635             


Ala Asn  Tyr Pro Asn Asn Gln  Asn Cys Ser Trp Ile  Ile Gln Ala 
    1640                 1645                 1650             


Gln Pro  Pro Leu Asn His Ile  Thr Leu Ser Phe Thr  His Phe Glu 
    1655                 1660                 1665             


Leu Glu  Arg Ser Thr Thr Cys  Ala Arg Asp Phe Val  Glu Ile Leu 
    1670                 1675                 1680             


Asp Gly  Gly His Glu Asp Ala  Pro Leu Arg Gly Arg  Tyr Cys Gly 
    1685                 1690                 1695             


Thr Asp  Met Pro His Pro Ile  Thr Ser Phe Ser Ser  Ala Leu Thr 
    1700                 1705                 1710             


Leu Arg  Phe Val Ser Asp Ser  Ser Ile Ser Ala Gly  Gly Phe His 
    1715                 1720                 1725             


Thr Thr  Val Thr Ala Ser Val  Ser Ala Cys Gly Gly  Thr Phe Tyr 
    1730                 1735                 1740             


Met Ala  Glu Gly Ile Phe Asn  Ser Pro Gly Tyr Pro  Asp Ile Tyr 
    1745                 1750                 1755             


Pro Pro  Asn Val Glu Cys Val  Trp Asn Ile Val Ser  Ser Pro Gly 
    1760                 1765                 1770             


Asn Arg  Leu Gln Leu Ser Phe  Ile Ser Phe Gln Leu  Glu Asp Ser 
    1775                 1780                 1785             


Gln Asp  Cys Ser Arg Asp Phe  Val Glu Ile Arg Glu  Gly Asn Ala 
    1790                 1795                 1800             


Thr Gly  His Leu Val Gly Arg  Tyr Cys Gly Asn Ser  Phe Pro Leu 
    1805                 1810                 1815             


Asn Tyr  Ser Ser Ile Val Gly  His Thr Leu Trp Val  Arg Phe Ile 
    1820                 1825                 1830             


Ser Asp  Gly Ser Gly Ser Gly  Thr Gly Phe Gln Ala  Thr Phe Met 
    1835                 1840                 1845             


Lys Ile  Phe Gly Asn Asp Asn  Ile Val Gly Thr His  Gly Lys Val 
    1850                 1855                 1860             


Ala Ser  Pro Phe Trp Pro Glu  Asn Tyr Pro His Asn  Ser Asn Tyr 
    1865                 1870                 1875             


Gln Trp  Thr Val Asn Val Asn  Ala Ser His Val Val  His Gly Arg 
    1880                 1885                 1890             


Ile Leu  Glu Met Asp Ile Glu  Glu Ile Gln Asn Cys  Tyr Tyr Asp 
    1895                 1900                 1905             


Lys Leu  Arg Ile Tyr Asp Gly  Pro Ser Ile His Ala  Arg Leu Ile 
    1910                 1915                 1920             


Gly Ala  Tyr Cys Gly Thr Gln  Thr Glu Ser Phe Ser  Ser Thr Gly 
    1925                 1930                 1935             


Asn Ser  Leu Thr Phe His Phe  Tyr Ser Asp Ser Ser  Ile Ser Gly 
    1940                 1945                 1950             


Lys Gly  Phe Leu Leu Glu Trp  Phe Ala Val Asp Ala  Pro Asp Gly 
    1955                 1960                 1965             


Val Leu  Pro Thr Ile Ala Pro  Gly Ala Cys Gly Gly  Phe Leu Arg 
    1970                 1975                 1980             


Thr Gly  Asp Ala Pro Val Phe  Leu Phe Ser Pro Gly  Trp Pro Asp 
    1985                 1990                 1995             


Ser Tyr  Ser Asn Arg Val Asp  Cys Thr Trp Leu Ile  Gln Ala Pro 
    2000                 2005                 2010             


Asp Ser  Thr Val Glu Leu Asn  Ile Leu Ser Leu Asp  Ile Glu Ser 
    2015                 2020                 2025             


His Arg  Thr Cys Ala Tyr Asp  Ser Leu Val Ile Arg  Asp Gly Asp 
    2030                 2035                 2040             


Asn Asn  Leu Ala Gln Gln Leu  Ala Val Leu Cys Gly  Arg Glu Ile 
    2045                 2050                 2055             


Pro Gly  Pro Ile Arg Ser Thr  Gly Glu Tyr Met Phe  Ile Arg Phe 
    2060                 2065                 2070             


Thr Ser  Asp Ser Ser Val Thr  Arg Ala Gly Phe Asn  Ala Ser Phe 
    2075                 2080                 2085             


His Lys  Ser Cys Gly Gly Tyr  Leu His Ala Asp Arg  Gly Ile Ile 
    2090                 2095                 2100             


Thr Ser  Pro Lys Tyr Pro Glu  Thr Tyr Pro Ser Asn  Leu Asn Cys 
    2105                 2110                 2115             


Ser Trp  His Val Leu Val Gln  Ser Gly Leu Thr Ile  Ala Val His 
    2120                 2125                 2130             


Phe Glu  Gln Pro Phe Gln Ile  Pro Asn Gly Asp Ser  Ser Cys Asn 
    2135                 2140                 2145             


Gln Gly  Asp Tyr Leu Val Leu  Arg Asn Gly Pro Asp  Ile Cys Ser 
    2150                 2155                 2160             


Pro Pro  Leu Gly Pro Pro Gly  Gly Asn Gly His Phe  Cys Gly Ser 
    2165                 2170                 2175             


His Ala  Ser Ser Thr Leu Phe  Thr Ser Asp Asn Gln  Met Phe Val 
    2180                 2185                 2190             


Gln Phe  Ile Ser Asp His Ser  Asn Glu Gly Gln Gly  Phe Lys Ile 
    2195                 2200                 2205             


Lys Tyr  Glu Ala Lys Ser Leu  Ala Cys Gly Gly Asn  Val Tyr Ile 
    2210                 2215                 2220             


His Asp  Ala Asp Ser Ala Gly  Tyr Val Thr Ser Pro  Asn His Pro 
    2225                 2230                 2235             


His Asn  Tyr Pro Pro His Ala  Asp Cys Ile Trp Ile  Leu Ala Ala 
    2240                 2245                 2250             


Pro Pro  Glu Thr Arg Ile Gln  Leu Gln Phe Glu Asp  Arg Phe Asp 
    2255                 2260                 2265             


Ile Glu  Val Thr Pro Asn Cys  Thr Ser Asn Tyr Leu  Glu Leu Arg 
    2270                 2275                 2280             


Asp Gly  Val Asp Ser Asp Ala  Pro Ile Leu Ser Lys  Phe Cys Gly 
    2285                 2290                 2295             


Thr Ser  Leu Pro Ser Ser Gln  Trp Ser Ser Gly Glu  Val Met Tyr 
    2300                 2305                 2310             


Leu Arg  Phe Arg Ser Asp Asn  Ser Pro Thr His Val  Gly Phe Lys 
    2315                 2320                 2325             


Ala Lys  Tyr Ser Ile Ala Gln  Cys Gly Gly Arg Val  Pro Gly Gln 
    2330                 2335                 2340             


Ser Gly  Val Val Glu Ser Ile  Gly His Pro Thr Leu  Pro Tyr Arg 
    2345                 2350                 2355             


Asp Asn  Leu Phe Cys Glu Trp  His Leu Gln Gly Leu  Ser Gly His 
    2360                 2365                 2370             


Tyr Leu  Thr Ile Ser Phe Glu  Asp Phe Asn Leu Gln  Asn Ser Ser 
    2375                 2380                 2385             


Gly Cys  Glu Lys Asp Phe Val  Glu Ile Trp Asp Asn  His Thr Ser 
    2390                 2395                 2400             


Gly Asn  Ile Leu Gly Arg Tyr  Cys Gly Asn Thr Ile  Pro Asp Ser 
    2405                 2410                 2415             


Ile Asp  Thr Ser Ser Asn Thr  Ala Val Val Arg Phe  Val Thr Asp 
    2420                 2425                 2430             


Gly Ser  Val Thr Ala Ser Gly  Phe Arg Leu Arg Phe  Glu Ser Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Gly Gly Asp  Leu Gln Gly Ser Ile  Gly Thr Phe 
    2450                 2455                 2460             


Thr Ser  Pro Asn Tyr Pro Asn  Pro Asn Pro His Gly  Arg Ile Cys 
    2465                 2470                 2475             


Glu Trp  Arg Ile Thr Ala Pro  Glu Gly Arg Arg Ile  Thr Leu Met 
    2480                 2485                 2490             


Phe Asn  Asn Leu Arg Leu Ala  Thr His Pro Ser Cys  Asn Asn Glu 
    2495                 2500                 2505             


His Val  Ile Val Phe Asn Gly  Ile Arg Ser Asn Ser  Pro Gln Leu 
    2510                 2515                 2520             


Glu Lys  Leu Cys Ser Ser Val  Asn Val Ser Asn Glu  Ile Lys Ser 
    2525                 2530                 2535             


Ser Gly  Asn Thr Met Lys Val  Ile Phe Phe Thr Asp  Gly Ser Arg 
    2540                 2545                 2550             


Pro Tyr  Gly Gly Phe Thr Ala  Ser Tyr Thr Ser Ser  Glu Asp Ala 
    2555                 2560                 2565             


Val Cys  Gly Gly Ser Leu Pro  Asn Thr Pro Glu Gly  Asn Phe Thr 
    2570                 2575                 2580             


Ser Pro  Gly Tyr Asp Gly Val  Arg Asn Tyr Ser Arg  Asn Leu Asn 
    2585                 2590                 2595             


Cys Glu  Trp Thr Leu Ser Asn  Pro Asn Gln Gly Asn  Ser Ser Ile 
    2600                 2605                 2610             


Ser Ile  His Phe Glu Asp Phe  Tyr Leu Glu Ser His  Gln Asp Cys 
    2615                 2620                 2625             


Gln Phe  Asp Val Leu Glu Phe  Arg Val Gly Asp Ala  Asp Gly Pro 
    2630                 2635                 2640             


Leu Met  Trp Arg Leu Cys Gly  Pro Ser Lys Pro Thr  Leu Pro Leu 
    2645                 2650                 2655             


Val Ile  Pro Tyr Ser Gln Val  Trp Ile His Phe Val  Thr Asn Glu 
    2660                 2665                 2670             


Arg Val  Glu His Ile Gly Phe  His Ala Lys Tyr Ser  Phe Thr Asp 
    2675                 2680                 2685             


Cys Gly  Gly Ile Gln Ile Gly  Asp Ser Gly Val Ile  Thr Ser Pro 
    2690                 2695                 2700             


Asn Tyr  Pro Asn Ala Tyr Asp  Ser Leu Thr His Cys  Ser Ser Leu 
    2705                 2710                 2715             


Leu Glu  Ala Pro Gln Gly His  Thr Ile Thr Leu Thr  Phe Ser Asp 
    2720                 2725                 2730             


Phe Asp  Ile Glu Pro His Thr  Thr Cys Ala Trp Asp  Ser Val Thr 
    2735                 2740                 2745             


Val Arg  Asn Gly Gly Ser Pro  Glu Ser Pro Ile Ile  Gly Gln Tyr 
    2750                 2755                 2760             


Cys Gly  Asn Ser Asn Pro Arg  Thr Ile Gln Ser Gly  Ser Asn Gln 
    2765                 2770                 2775             


Leu Val  Val Thr Phe Asn Ser  Asp His Ser Leu Gln  Gly Gly Gly 
    2780                 2785                 2790             


Phe Tyr  Ala Thr Trp Asn Thr  Gln Thr Leu Gly Cys  Gly Gly Ile 
    2795                 2800                 2805             


Phe His  Ser Asp Asn Gly Thr  Ile Arg Ser Pro His  Trp Pro Gln 
    2810                 2815                 2820             


Asn Phe  Pro Glu Asn Ser Arg  Cys Ser Trp Thr Ala  Ile Thr His 
    2825                 2830                 2835             


Lys Ser  Lys His Leu Glu Ile  Ser Phe Asp Asn Asn  Phe Leu Ile 
    2840                 2845                 2850             


Pro Ser  Gly Asp Gly Gln Cys  Gln Asn Ser Phe Val  Lys Val Trp 
    2855                 2860                 2865             


Ala Gly  Thr Glu Glu Val Asp  Lys Ala Leu Leu Ala  Thr Gly Cys 
    2870                 2875                 2880             


Gly Asn  Val Ala Pro Gly Pro  Val Ile Thr Pro Ser  Asn Thr Phe 
    2885                 2890                 2895             


Thr Ala  Val Phe Gln Ser Gln  Glu Ala Pro Ala Gln  Gly Phe Ser 
    2900                 2905                 2910             


Ala Ser  Phe Val Ser Arg Cys  Gly Ser Asn Phe Thr  Gly Pro Ser 
    2915                 2920                 2925             


Gly Tyr  Ile Ile Ser Pro Asn  Tyr Pro Lys Gln Tyr  Asp Asn Asn 
    2930                 2935                 2940             


Met Asn  Cys Thr Tyr Val Ile  Glu Ala Asn Pro Leu  Ser Val Val 
    2945                 2950                 2955             


Leu Leu  Thr Phe Val Ser Phe  His Leu Glu Ala Arg  Ser Ala Val 
    2960                 2965                 2970             


Thr Gly  Ser Cys Val Asn Asp  Gly Val His Ile Ile  Arg Gly Tyr 
    2975                 2980                 2985             


Ser Val  Met Ser Thr Pro Phe  Ala Thr Val Cys Gly  Asp Glu Met 
    2990                 2995                 3000             


Pro Ala  Pro Leu Thr Ile Ala  Gly Pro Val Leu Leu  Asn Phe Tyr 
    3005                 3010                 3015             


Ser Asn  Glu Gln Ile Thr Asp  Phe Gly Phe Lys Phe  Ser Tyr Arg 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Gly Val  Phe Asn Phe Ser Ser  Gly Ile Ile 
    3035                 3040                 3045             


Thr Ser  Pro Ala Tyr Ser Tyr  Ala Asp Tyr Pro Asn  Asp Met His 
    3050                 3055                 3060             


Cys Leu  Tyr Thr Ile Thr Val  Ser Asp Asp Lys Val  Ile Glu Leu 
    3065                 3070                 3075             


Lys Phe  Ser Asp Phe Asp Val  Val Pro Ser Thr Ser  Cys Ser His 
    3080                 3085                 3090             


Asp Tyr  Leu Ala Ile Tyr Asp  Gly Ala Asn Thr Ser  Asp Pro Leu 
    3095                 3100                 3105             


Leu Gly  Lys Phe Cys Gly Ser  Lys Arg Pro Pro Asn  Val Lys Ser 
    3110                 3115                 3120             


Ser Asn  Asn Ser Met Leu Leu  Val Phe Lys Thr Asp  Ser Phe Gln 
    3125                 3130                 3135             


Thr Ala  Lys Gly Trp Lys Met  Ser Phe Arg Gln Thr  Leu Gly Pro 
    3140                 3145                 3150             


Gln Gln  Gly Cys Gly Gly Tyr  Leu Thr Gly Ser Asn  Asn Thr Phe 
    3155                 3160                 3165             


Ala Ser  Pro Asp Ser Asp Ser  Asn Gly Met Tyr Asp  Lys Asn Leu 
    3170                 3175                 3180             


Asn Cys  Val Trp Ile Ile Ile  Ala Pro Val Asn Lys  Val Ile His 
    3185                 3190                 3195             


Leu Thr  Phe Asn Thr Phe Ala  Leu Glu Ala Ala Ser  Thr Arg Gln 
    3200                 3205                 3210             


Arg Cys  Leu Tyr Asp Tyr Val  Lys Leu Tyr Asp Gly  Asp Ser Glu 
    3215                 3220                 3225             


Asn Ala  Asn Leu Ala Gly Thr  Phe Cys Gly Ser Thr  Val Pro Ala 
    3230                 3235                 3240             


Pro Phe  Ile Ser Ser Gly Asn  Phe Leu Thr Val Gln  Phe Ile Ser 
    3245                 3250                 3255             


Asp Leu  Thr Leu Glu Arg Glu  Gly Phe Asn Ala Thr  Tyr Thr Ile 
    3260                 3265                 3270             


Met Asp  Met Pro Cys Gly Gly  Thr Tyr Asn Ala Thr  Trp Thr Pro 
    3275                 3280                 3285             


Gln Asn  Ile Ser Ser Pro Asn  Ser Ser Asp Pro Asp  Val Pro Phe 
    3290                 3295                 3300             


Ser Ile  Cys Thr Trp Val Ile  Asp Ser Pro Pro His  Gln Gln Val 
    3305                 3310                 3315             


Lys Ile  Thr Val Trp Ala Leu  Gln Leu Thr Ser Gln  Asp Cys Thr 
    3320                 3325                 3330             


Gln Asn  Tyr Leu Gln Leu Gln  Asp Ser Pro Gln Gly  His Gly Asn 
    3335                 3340                 3345             


Ser Arg  Phe Gln Phe Cys Gly  Arg Asn Ala Ser Ala  Val Pro Val 
    3350                 3355                 3360             


Phe Tyr  Ser Ser Met Ser Thr  Ala Met Val Ile Phe  Lys Ser Gly 
    3365                 3370                 3375             


Val Val  Asn Arg Asn Ser Arg  Met Ser Phe Thr Tyr  Gln Ile Ala 
    3380                 3385                 3390             


Asp Cys  Asn Arg Asp Tyr His  Lys Ala Phe Gly Asn  Leu Arg Ser 
    3395                 3400                 3405             


Pro Gly  Trp Pro Asp Asn Tyr  Asp Asn Asp Lys Asp  Cys Thr Val 
    3410                 3415                 3420             


Thr Leu  Thr Ala Pro Gln Asn  His Thr Ile Ser Leu  Phe Phe His 
    3425                 3430                 3435             


Ser Leu  Gly Ile Glu Asn Ser  Val Glu Cys Arg Asn  Asp Phe Leu 
    3440                 3445                 3450             


Glu Val  Arg Asn Gly Ser Asn  Ser Asn Ser Pro Leu  Leu Gly Lys 
    3455                 3460                 3465             


Tyr Cys  Gly Thr Leu Leu Pro  Asn Pro Val Phe Ser  Gln Asn Asn 
    3470                 3475                 3480             


Glu Leu  Tyr Leu Arg Phe Lys  Ser Asp Ser Val Thr  Ser Asp Arg 
    3485                 3490                 3495             


Gly Tyr  Glu Ile Ile Trp Thr  Ser Ser Pro Ser Gly  Cys Gly Gly 
    3500                 3505                 3510             


Thr Leu  Tyr Gly Asp Arg Gly  Ser Phe Thr Ser Pro  Gly Tyr Pro 
    3515                 3520                 3525             


Gly Thr  Tyr Pro Asn Asn Thr  Tyr Cys Glu Trp Val  Leu Val Ala 
    3530                 3535                 3540             


Pro Ala  Gly Arg Leu Val Thr  Ile Asn Phe Tyr Phe  Ile Ser Ile 
    3545                 3550                 3555             


Asp Asp  Pro Gly Asp Cys Val  Gln Asn Tyr Leu Thr  Leu Tyr Asp 
    3560                 3565                 3570             


Gly Pro  Asn Ala Ser Ser Pro  Ser Ser Gly Pro Tyr  Cys Gly Gly 
    3575                 3580                 3585             


Asp Thr  Ser Ile Ala Pro Phe  Val Ala Ser Ser Asn  Gln Val Phe 
    3590                 3595                 3600             


Ile Lys  Phe His Ala Asp Tyr  Ala Arg Arg Pro Ser  Ala Phe Arg 
    3605                 3610                 3615             


Leu Thr  Trp Asp Ser 
    3620             


<210>  2733
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUEDC1__Homo_sapiens__NP_001278954

<400>  2733

Met Thr Ser Leu Phe Arg Arg Ser Ser Ser Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Thr Ala Gly Ala Arg Gly Gly Gly Gly Gly Thr Ala Ala Pro Gln Glu 
            20                  25                  30          


Leu Asn Asn Ser Arg Pro Ala Arg Gln Val Arg Arg Leu Glu Phe Asn 
        35                  40                  45              


Gln Ala Met Asp Asp Phe Lys Thr Met Phe Pro Asn Met Asp Tyr Asp 
    50                  55                  60                  


Ile Ile Glu Cys Val Leu Arg Ala Asn Ser Gly Ala Val Asp Ala Thr 
65                  70                  75                  80  


Ile Asp Gln Leu Leu Gln Met Asn Leu Glu Gly Gly Gly Ser Ser Gly 
                85                  90                  95      


Gly Val Tyr Glu Asp Ser Ser Asp Ser Glu Asp Ser Ile Pro Pro Glu 
            100                 105                 110         


Ile Leu Glu Arg Thr Leu Glu Pro Asp Ser Ser Asp Glu Glu Pro Pro 
        115                 120                 125             


Pro Val Tyr Ser Pro Pro Ala Tyr His Met His Val Phe Asp Arg Pro 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Pro Thr Pro Pro Pro Arg Ile Asp Ala Leu Gly 
145                 150                 155                 160 


Ser Gly Ala Pro Thr Ser Gln Arg Arg Tyr Arg Asn Trp Asn Pro Pro 
                165                 170                 175     


Leu Leu Gly Asn Leu Pro Asp Asp Phe Leu Arg Ile Leu Pro Gln Gln 
            180                 185                 190         


Leu Asp Ser Ile Gln Gly Asn Ala Gly Gly Pro Lys Pro Gly Ser Gly 
        195                 200                 205             


Glu Gly Cys Pro Pro Ala Met Ala Gly Pro Gly Pro Gly Asp Gln Glu 
    210                 215                 220                 


Ser Arg Trp Lys Gln Tyr Leu Glu Asp Glu Arg Ile Ala Leu Phe Leu 
225                 230                 235                 240 


Gln Asn Glu Glu Phe Met Lys Glu Leu Gln Arg Asn Arg Asp Phe Leu 
                245                 250                 255     


Leu Ala Leu Glu Arg Asp Arg Leu Lys Tyr Glu Ser Gln Lys Ser Lys 
            260                 265                 270         


Ser Ser Ser Val Ala Val Gly Asn Asp Phe Gly Phe Ser Ser Pro Val 
        275                 280                 285             


Pro Gly Thr Gly Asp Ala Asn Pro Ala Val Ser Glu Asp Ala Leu Phe 
    290                 295                 300                 


Arg Asp Lys Leu Lys His Met Gly Lys Ser Thr Arg Arg Lys Leu Phe 
305                 310                 315                 320 


Glu Leu Ala Arg Ala Phe Ser Glu Lys Thr Lys Met Arg Lys Ser Lys 
                325                 330                 335     


Arg Lys His Leu Leu Lys His Gln Ser Leu Gly Ala Ala Ala Ser Thr 
            340                 345                 350         


Ala Asn Leu Leu Asp Asp Val Glu Gly His Ala Cys Asp Glu Asp Phe 
        355                 360                 365             


Arg Gly Arg Arg Gln Glu Ala Pro Lys Val Glu Glu Gly Leu Arg Glu 
    370                 375                 380                 


Gly Gln 
385     


<210>  2734
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUEDC2__Homo_sapiens__NP_076945

<400>  2734

Met Glu Leu Glu Arg Ile Val Ser Ala Ala Leu Leu Ala Phe Val Gln 
1               5                   10                  15      


Thr His Leu Pro Glu Ala Asp Leu Ser Gly Leu Asp Glu Val Ile Phe 
            20                  25                  30          


Ser Tyr Val Leu Gly Val Leu Glu Asp Leu Gly Pro Ser Gly Pro Ser 
        35                  40                  45              


Glu Glu Asn Phe Asp Met Glu Ala Phe Thr Glu Met Met Glu Ala Tyr 
    50                  55                  60                  


Val Pro Gly Phe Ala His Ile Pro Arg Gly Thr Ile Gly Asp Met Met 
65                  70                  75                  80  


Gln Lys Leu Ser Gly Gln Leu Ser Asp Ala Arg Asn Lys Glu Asn Leu 
                85                  90                  95      


Gln Pro Gln Ser Ser Gly Val Gln Gly Gln Val Pro Ile Ser Pro Glu 
            100                 105                 110         


Pro Leu Gln Arg Pro Glu Met Leu Lys Glu Glu Thr Arg Ser Ser Ala 
        115                 120                 125             


Ala Ala Ala Ala Asp Thr Gln Asp Glu Ala Thr Gly Ala Glu Glu Glu 
    130                 135                 140                 


Leu Leu Pro Gly Val Asp Val Leu Leu Glu Val Phe Pro Thr Cys Ser 
145                 150                 155                 160 


Val Glu Gln Ala Gln Trp Val Leu Ala Lys Ala Arg Gly Asp Leu Glu 
                165                 170                 175     


Glu Ala Val Gln Met Leu Val Glu Gly Lys Glu Glu Gly Pro Ala Ala 
            180                 185                 190         


Trp Glu Gly Pro Asn Gln Asp Leu Pro Arg Arg Leu Arg Gly Pro Gln 
        195                 200                 205             


Lys Asp Glu Leu Lys Ser Phe Ile Leu Gln Lys Tyr Met Met Val Asp 
    210                 215                 220                 


Ser Ala Glu Asp Gln Lys Ile His Arg Pro Met Ala Pro Lys Glu Ala 
225                 230                 235                 240 


Pro Lys Lys Leu Ile Arg Tyr Ile Asp Asn Gln Val Val Ser Thr Lys 
                245                 250                 255     


Gly Glu Arg Phe Lys Asp Val Arg Asn Pro Glu Ala Glu Glu Met Lys 
            260                 265                 270         


Ala Thr Tyr Ile Asn Leu Lys Pro Ala Arg Lys Tyr Arg Phe His 
        275                 280                 285         


<210>  2735
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL1__Homo_sapiens__XP_011514934

<400>  2735

Met Ser Ser Thr Arg Ser Gln Asn Pro His Gly Leu Lys Gln Ile Gly 
1               5                   10                  15      


Leu Asp Gln Ile Trp Asp Asp Leu Arg Ala Gly Ile Gln Gln Val Tyr 
            20                  25                  30          


Thr Arg Gln Ser Met Ala Lys Ser Arg Tyr Met Glu Leu Tyr Thr His 
        35                  40                  45              


Val Tyr Asn Tyr Cys Thr Ser Val His Gln Ser Asn Gln Ala Arg Gly 
    50                  55                  60                  


Ala Gly Val Pro Pro Ser Lys Ser Lys Lys Gly Gln Thr Pro Gly Gly 
65                  70                  75                  80  


Ala Gln Phe Val Gly Leu Glu Leu Tyr Lys Arg Leu Lys Glu Phe Leu 
                85                  90                  95      


Lys Asn Tyr Leu Thr Asn Leu Leu Lys Asp Gly Glu Asp Leu Met Asp 
            100                 105                 110         


Glu Ser Val Leu Lys Phe Tyr Thr Gln Gln Trp Glu Asp Tyr Arg Phe 
        115                 120                 125             


Ser Ser Lys Val Leu Asn Gly Ile Cys Ala Tyr Leu Asn Arg His Trp 
    130                 135                 140                 


Val Arg Arg Glu Cys Asp Glu Gly Arg Lys Gly Ile Tyr Glu Ile Tyr 
145                 150                 155                 160 


Ser Leu Ala Leu Val Thr Trp Arg Asp Cys Leu Phe Arg Pro Leu Asn 
                165                 170                 175     


Lys Gln Val Thr Asn Ala Val Leu Lys Leu Ile Glu Lys Glu Arg Asn 
            180                 185                 190         


Gly Glu Thr Ile Asn Thr Arg Leu Ile Ser Gly Val Val Gln Ser Tyr 
        195                 200                 205             


Val Glu Leu Gly Leu Asn Glu Asp Asp Ala Phe Ala Lys Gly Pro Thr 
    210                 215                 220                 


Leu Thr Val Tyr Lys Glu Ser Phe Glu Ser Gln Phe Leu Ala Asp Thr 
225                 230                 235                 240 


Glu Arg Phe Tyr Thr Arg Glu Ser Thr Glu Phe Leu Gln Gln Asn Pro 
                245                 250                 255     


Val Thr Glu Tyr Met Lys Lys Ala Glu Ala Arg Leu Leu Glu Glu Gln 
            260                 265                 270         


Arg Arg Val Gln Val Tyr Leu His Glu Ser Thr Gln Asp Glu Leu Ala 
        275                 280                 285             


Arg Lys Cys Glu Gln Val Leu Ile Glu Lys His Leu Glu Ile Phe His 
    290                 295                 300                 


Thr Glu Phe Gln Asn Leu Leu Asp Ala Asp Lys Asn Glu Asp Leu Gly 
305                 310                 315                 320 


Arg Met Tyr Asn Leu Val Ser Arg Ile Gln Asp Gly Leu Gly Glu Leu 
                325                 330                 335     


Lys Lys Leu Leu Glu Thr His Ile His Asn Gln Gly Leu Ala Ala Ile 
            340                 345                 350         


Glu Lys Cys Gly Glu Ala Ala Leu Asn Asp Pro Lys Met Tyr Val Gln 
        355                 360                 365             


Thr Val Leu Asp Val His Lys Lys Tyr Asn Ala Leu Val Met Ser Ala 
    370                 375                 380                 


Phe Asn Asn Asp Ala Gly Phe Val Ala Ala Leu Asp Lys Ala Cys Gly 
385                 390                 395                 400 


Arg Phe Ile Asn Asn Asn Ala Val Thr Lys Met Ala Gln Ser Ser Ser 
                405                 410                 415     


Lys Ser Pro Glu Leu Leu Ala Arg Tyr Cys Asp Ser Leu Leu Lys Lys 
            420                 425                 430         


Ser Ser Lys Asn Pro Glu Glu Ala Glu Leu Glu Asp Thr Leu Asn Gln 
        435                 440                 445             


Val Met Val Val Phe Lys Tyr Ile Glu Asp Lys Asp Val Phe Gln Lys 
    450                 455                 460                 


Phe Tyr Ala Lys Met Leu Ala Lys Arg Leu Val His Gln Asn Ser Ala 
465                 470                 475                 480 


Ser Asp Asp Ala Glu Ala Ser Met Ile Ser Lys Leu Lys Gln Ala Cys 
                485                 490                 495     


Gly Phe Glu Tyr Thr Ser Lys Leu Gln Arg Met Phe Gln Asp Ile Gly 
            500                 505                 510         


Val Ser Lys Asp Leu Asn Glu Gln Phe Lys Lys His Leu Thr Asn Ser 
        515                 520                 525             


Glu Pro Leu Asp Leu Asp Phe Ser Ile Gln Val Leu Ser Ser Gly Ser 
    530                 535                 540                 


Trp Pro Phe Gln Gln Ser Cys Thr Phe Ala Leu Pro Ser Glu Leu Glu 
545                 550                 555                 560 


Arg Ser Tyr Gln Arg Phe Thr Ala Phe Tyr Ala Ser Arg His Ser Gly 
                565                 570                 575     


Arg Lys Leu Thr Trp Leu Tyr Gln Leu Ser Lys Gly Glu Leu Val Thr 
            580                 585                 590         


Asn Cys Phe Lys Asn Arg Tyr Thr Leu Gln Ala Ser Thr Phe Gln Met 
        595                 600                 605             


Ala Ile Leu Leu Gln Tyr Asn Thr Glu Asp Ala Tyr Thr Val Gln Gln 
    610                 615                 620                 


Leu Thr Asp Ser Thr Gln Ile Lys Met Asp Ile Leu Ala Gln Val Leu 
625                 630                 635                 640 


Gln Ile Leu Leu Lys Ser Lys Leu Leu Val Leu Glu Asp Glu Asn Ala 
                645                 650                 655     


Asn Val Asp Glu Val Glu Leu Lys Pro Asp Thr Leu Ile Lys Leu Tyr 
            660                 665                 670         


Leu Gly Tyr Lys Asn Lys Lys Leu Arg Val Asn Ile Asn Val Pro Met 
        675                 680                 685             


Lys Thr Glu Gln Lys Gln Glu Gln Glu Thr Thr His Lys Asn Ile Glu 
    690                 695                 700                 


Glu Asp Arg Lys Leu Leu Ile Gln Ala Ala Ile Val Arg Ile Met Lys 
705                 710                 715                 720 


Met Arg Lys Val Leu Lys His Gln Gln Leu Leu Gly Glu Val Leu Thr 
                725                 730                 735     


Gln Leu Ser Ser Arg Phe Lys Pro Arg Val Pro Val Ile Lys Lys Cys 
            740                 745                 750         


Ile Asp Ile Leu Ile Glu Lys Glu Tyr Leu Glu Arg Val Asp Gly Glu 
        755                 760                 765             


Lys Asp Thr Tyr Ser Tyr Leu Ala 
    770                 775     


<210>  2736
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL2__Homo_sapiens__NP_001185707

<400>  2736

Met Tyr Arg Val Thr Trp Ser Thr Phe Trp Leu Arg Phe Gln His Tyr 
1               5                   10                  15      


Thr Cys Thr Met Ser Leu Lys Pro Arg Val Val Asp Phe Asp Glu Thr 
            20                  25                  30          


Trp Asn Lys Leu Leu Thr Thr Ile Lys Ala Val Val Met Leu Glu Tyr 
        35                  40                  45              


Val Glu Arg Ala Thr Trp Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu 
    50                  55                  60                  


Cys Val Ala Tyr Pro Glu Pro Leu Gly Glu Arg Leu Tyr Thr Glu Thr 
65                  70                  75                  80  


Lys Ile Phe Leu Glu Asn His Val Arg His Leu His Lys Arg Val Leu 
                85                  90                  95      


Glu Ser Glu Glu Gln Val Leu Val Met Tyr His Arg Tyr Trp Glu Glu 
            100                 105                 110         


Tyr Ser Lys Gly Ala Asp Tyr Met Asp Cys Leu Tyr Arg Tyr Leu Asn 
        115                 120                 125             


Thr Gln Phe Ile Lys Lys Asn Lys Leu Thr Glu Ala Asp Leu Gln Tyr 
    130                 135                 140                 


Gly Tyr Gly Gly Val Asp Met Asn Glu Pro Leu Met Glu Ile Gly Glu 
145                 150                 155                 160 


Leu Ala Leu Asp Met Trp Arg Lys Leu Met Val Glu Pro Leu Gln Ala 
                165                 170                 175     


Ile Leu Ile Arg Met Leu Leu Arg Glu Ile Lys Asn Asp Arg Gly Gly 
            180                 185                 190         


Glu Asp Pro Asn Gln Lys Val Ile His Gly Val Ile Asn Ser Phe Val 
        195                 200                 205             


His Val Glu Gln Tyr Lys Lys Lys Phe Pro Leu Lys Phe Tyr Gln Glu 
    210                 215                 220                 


Ile Phe Glu Ser Pro Phe Leu Thr Glu Thr Gly Glu Tyr Tyr Lys Gln 
225                 230                 235                 240 


Glu Ala Ser Asn Leu Leu Gln Glu Ser Asn Cys Ser Gln Tyr Met Glu 
                245                 250                 255     


Lys Val Leu Gly Arg Leu Lys Asp Glu Glu Ile Arg Cys Arg Lys Tyr 
            260                 265                 270         


Leu His Pro Ser Ser Tyr Thr Lys Val Ile His Glu Cys Gln Gln Arg 
        275                 280                 285             


Met Val Ala Asp His Leu Gln Phe Leu His Ala Glu Cys His Asn Ile 
    290                 295                 300                 


Ile Arg Gln Glu Lys Lys Asn Asp Met Ala Asn Met Tyr Val Leu Leu 
305                 310                 315                 320 


Arg Ala Val Ser Thr Gly Leu Pro His Met Ile Gln Glu Leu Gln Asn 
                325                 330                 335     


His Ile His Asp Glu Gly Leu Arg Ala Thr Ser Asn Leu Thr Gln Glu 
            340                 345                 350         


Asn Met Pro Thr Leu Phe Val Glu Ser Val Leu Glu Val His Gly Lys 
        355                 360                 365             


Phe Val Gln Leu Ile Asn Thr Val Leu Asn Gly Asp Gln His Phe Met 
    370                 375                 380                 


Ser Ala Leu Asp Lys Ala Leu Thr Ser Val Val Asn Tyr Arg Glu Pro 
385                 390                 395                 400 


Lys Ser Val Cys Lys Ala Pro Glu Leu Leu Ala Lys Tyr Cys Asp Asn 
                405                 410                 415     


Leu Leu Lys Lys Ser Ala Lys Gly Met Thr Glu Asn Glu Val Glu Asp 
            420                 425                 430         


Arg Leu Thr Ser Phe Ile Thr Val Phe Lys Tyr Ile Asp Asp Lys Asp 
        435                 440                 445             


Val Phe Gln Lys Phe Tyr Ala Arg Met Leu Ala Lys Arg Leu Ile His 
    450                 455                 460                 


Gly Leu Ser Met Ser Met Asp Ser Glu Glu Ala Met Ile Asn Lys Leu 
465                 470                 475                 480 


Lys Gln Ala Cys Gly Tyr Glu Phe Thr Ser Lys Leu His Arg Met Tyr 
                485                 490                 495     


Thr Asp Met Ser Val Ser Ala Asp Leu Asn Asn Lys Phe Asn Asn Phe 
            500                 505                 510         


Ile Lys Asn Gln Asp Thr Val Ile Asp Leu Gly Ile Ser Phe Gln Ile 
        515                 520                 525             


Tyr Val Leu Gln Ala Gly Ala Trp Pro Leu Thr Gln Ala Pro Ser Ser 
    530                 535                 540                 


Thr Phe Ala Ile Pro Gln Glu Leu Glu Lys Ser Val Gln Met Phe Glu 
545                 550                 555                 560 


Leu Phe Tyr Ser Gln His Phe Ser Gly Arg Lys Leu Thr Trp Leu His 
                565                 570                 575     


Tyr Leu Cys Thr Gly Glu Val Lys Met Asn Tyr Leu Gly Lys Pro Tyr 
            580                 585                 590         


Val Ala Met Val Thr Thr Tyr Gln Met Ala Val Leu Leu Ala Phe Asn 
        595                 600                 605             


Asn Ser Glu Thr Val Ser Tyr Lys Glu Leu Gln Asp Ser Thr Gln Met 
    610                 615                 620                 


Asn Glu Lys Glu Leu Thr Lys Thr Ile Lys Ser Leu Leu Asp Val Lys 
625                 630                 635                 640 


Met Ile Asn His Asp Ser Glu Lys Glu Asp Ile Asp Ala Glu Ser Ser 
                645                 650                 655     


Phe Ser Leu Asn Met Asn Phe Ser Ser Lys Arg Thr Lys Phe Lys Ile 
            660                 665                 670         


Thr Thr Ser Met Gln Lys Asp Thr Pro Gln Glu Met Glu Gln Thr Arg 
        675                 680                 685             


Ser Ala Val Asp Glu Asp Arg Lys Met Tyr Leu Gln Ala Ala Ile Val 
    690                 695                 700                 


Arg Ile Met Lys Ala Arg Lys Val Leu Arg His Asn Ala Leu Ile Gln 
705                 710                 715                 720 


Glu Val Ile Ser Gln Ser Arg Ala Arg Phe Asn Pro Ser Ile Ser Met 
                725                 730                 735     


Ile Lys Lys Cys Ile Glu Val Leu Ile Asp Lys Gln Tyr Ile Glu Arg 
            740                 745                 750         


Ser Gln Ala Ser Ala Asp Glu Tyr Ser Tyr Val Ala 
        755                 760                 


<210>  2737
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL3__Homo_sapiens__NP_001244126

<400>  2737

Met Ser Asn Leu Ser Lys Gly Thr Gly Ser Arg Lys Asp Thr Lys Met 
1               5                   10                  15      


Arg Ile Arg Ala Phe Pro Val Arg Glu Asp Val Leu Asn Ser Leu Asn 
            20                  25                  30          


Asn Asn Phe Leu Gln Thr Leu Asn Gln Ala Trp Asn Asp His Gln Thr 
        35                  40                  45              


Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg Val Tyr 
    50                  55                  60                  


Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu Ile Ile 
65                  70                  75                  80  


Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His Leu Arg 
                85                  90                  95      


Gln Thr Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu Val Val 
            100                 105                 110         


Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile Leu Gly 
        115                 120                 125             


Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro Phe Leu 
    130                 135                 140                 


Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe Leu Ala 
145                 150                 155                 160 


Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg Ile Asn 
                165                 170                 175     


Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Thr Glu Glu 
            180                 185                 190         


Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His Met Lys 
        195                 200                 205             


Thr Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu Lys Asn 
    210                 215                 220                 


Gly Lys Thr Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser Arg Val 
225                 230                 235                 240 


Pro Asn Gly Leu Lys Thr Met Cys Glu Cys Met Ser Ser Tyr Leu Arg 
                245                 250                 255     


Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys Asn Pro 
            260                 265                 270         


Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe Asp Arg 
        275                 280                 285             


Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln Thr Ile 
    290                 295                 300                 


Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser Pro Glu 
305                 310                 315                 320 


Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val Lys Gly 
                325                 330                 335     


Leu Thr Glu Gln Glu Val Glu Thr Ile Leu Asp Lys Ala Met Val Leu 
            340                 345                 350         


Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr Lys Gln 
        355                 360                 365             


His Leu Ala Arg Arg Leu Leu Thr Asn Lys Ser Val Ser Asp Asp Ser 
    370                 375                 380                 


Glu Lys Asn Met Ile Ser Lys Leu Lys Thr Glu Cys Gly Cys Gln Phe 
385                 390                 395                 400 


Thr Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser Asn Thr 
                405                 410                 415     


Thr Met Asp Glu Phe Arg Gln His Leu Gln Ala Thr Gly Val Ser Leu 
            420                 425                 430         


Gly Gly Val Asp Leu Thr Val Arg Val Leu Thr Thr Gly Tyr Trp Pro 
        435                 440                 445             


Thr Gln Ser Ala Thr Pro Lys Cys Asn Ile Pro Pro Ala Pro Arg His 
    450                 455                 460                 


Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser Gly Arg 
465                 470                 475                 480 


Gln Leu Thr Leu Gln His His Met Gly Ser Ala Asp Leu Asn Ala Thr 
                485                 490                 495     


Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly Val Gly 
            500                 505                 510         


Gly Ala Gln Val Thr Gly Ser Asn Thr Arg Lys His Ile Leu Gln Val 
        515                 520                 525             


Ser Thr Phe Gln Met Thr Ile Leu Met Leu Phe Asn Asn Arg Glu Lys 
    530                 535                 540                 


Tyr Thr Phe Glu Glu Ile Gln Gln Glu Thr Asp Ile Pro Glu Arg Glu 
545                 550                 555                 560 


Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Thr Gln Arg 
                565                 570                 575     


Val Leu Thr Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly His Ile 
            580                 585                 590         


Phe Thr Val Asn Asp Gln Phe Thr Ser Lys Leu His Arg Val Lys Ile 
        595                 600                 605             


Gln Thr Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg Lys Glu 
    610                 615                 620                 


Thr Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu Ala Ala 
625                 630                 635                 640 


Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn Val Leu 
                645                 650                 655     


Val Ala Glu Val Thr Gln Gln Leu Lys Ala Arg Phe Leu Pro Ser Pro 
            660                 665                 670         


Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu Tyr Leu 
        675                 680                 685             


Ala Arg Thr Pro Glu Asp Arg Lys Val Tyr Thr Tyr Val Ala 
    690                 695                 700         


<210>  2738
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL4A__Homo_sapiens__NP_001008895

<400>  2738

Met Ala Asp Glu Ala Pro Arg Lys Gly Ser Phe Ser Ala Leu Val Gly 
1               5                   10                  15      


Arg Thr Asn Gly Leu Thr Lys Pro Ala Ala Leu Ala Ala Ala Pro Ala 
            20                  25                  30          


Lys Pro Gly Gly Ala Gly Gly Ser Lys Lys Leu Val Ile Lys Asn Phe 
        35                  40                  45              


Arg Asp Arg Pro Arg Leu Pro Asp Asn Tyr Thr Gln Asp Thr Trp Arg 
    50                  55                  60                  


Lys Leu His Glu Ala Val Arg Ala Val Gln Ser Ser Thr Ser Ile Arg 
65                  70                  75                  80  


Tyr Asn Leu Glu Glu Leu Tyr Gln Ala Val Glu Asn Leu Cys Ser His 
                85                  90                  95      


Lys Val Ser Pro Met Leu Tyr Lys Gln Leu Arg Gln Ala Cys Glu Asp 
            100                 105                 110         


His Val Gln Ala Gln Ile Leu Pro Phe Arg Glu Asp Ser Leu Asp Ser 
        115                 120                 125             


Val Leu Phe Leu Lys Lys Ile Asn Thr Cys Trp Gln Asp His Cys Arg 
    130                 135                 140                 


Gln Met Ile Met Ile Arg Ser Ile Phe Leu Phe Leu Asp Arg Thr Tyr 
145                 150                 155                 160 


Val Leu Gln Asn Ser Thr Leu Pro Ser Ile Trp Asp Met Gly Leu Glu 
                165                 170                 175     


Leu Phe Arg Thr His Ile Ile Ser Asp Lys Met Val Gln Ser Lys Thr 
            180                 185                 190         


Ile Asp Gly Ile Leu Leu Leu Ile Glu Arg Glu Arg Ser Gly Glu Ala 
        195                 200                 205             


Val Asp Arg Ser Leu Leu Arg Ser Leu Leu Gly Met Leu Ser Asp Leu 
    210                 215                 220                 


Gln Val Tyr Lys Asp Ser Phe Glu Leu Lys Phe Leu Glu Glu Thr Asn 
225                 230                 235                 240 


Cys Leu Tyr Ala Ala Glu Gly Gln Arg Leu Met Gln Glu Arg Glu Val 
                245                 250                 255     


Pro Glu Tyr Leu Asn His Val Ser Lys Arg Leu Glu Glu Glu Gly Asp 
            260                 265                 270         


Arg Val Ile Thr Tyr Leu Asp His Ser Thr Gln Lys Pro Leu Ile Ala 
        275                 280                 285             


Cys Val Glu Lys Gln Leu Leu Gly Glu His Leu Thr Ala Ile Leu Gln 
    290                 295                 300                 


Lys Gly Leu Asp His Leu Leu Asp Glu Asn Arg Val Pro Asp Leu Ala 
305                 310                 315                 320 


Gln Met Tyr Gln Leu Phe Ser Arg Val Arg Gly Gly Gln Gln Ala Leu 
                325                 330                 335     


Leu Gln His Trp Ser Glu Tyr Ile Lys Thr Phe Gly Thr Ala Ile Val 
            340                 345                 350         


Ile Asn Pro Glu Lys Asp Lys Asp Met Val Gln Asp Leu Leu Asp Phe 
        355                 360                 365             


Lys Asp Lys Val Asp His Val Ile Glu Val Cys Phe Gln Lys Asn Glu 
    370                 375                 380                 


Arg Phe Val Asn Leu Met Lys Glu Ser Phe Glu Thr Phe Ile Asn Lys 
385                 390                 395                 400 


Arg Pro Asn Lys Pro Ala Glu Leu Ile Ala Lys His Val Asp Ser Lys 
                405                 410                 415     


Leu Arg Ala Gly Asn Lys Glu Ala Thr Asp Glu Glu Leu Glu Arg Thr 
            420                 425                 430         


Leu Asp Lys Ile Met Ile Leu Phe Arg Phe Ile His Gly Lys Asp Val 
        435                 440                 445             


Phe Glu Ala Phe Tyr Lys Lys Asp Leu Ala Lys Arg Leu Leu Val Gly 
    450                 455                 460                 


Lys Ser Ala Ser Val Asp Ala Glu Lys Ser Met Leu Ser Lys Leu Lys 
465                 470                 475                 480 


His Glu Cys Gly Ala Ala Phe Thr Ser Lys Leu Glu Gly Met Phe Lys 
                485                 490                 495     


Asp Met Glu Leu Ser Lys Asp Ile Met Val His Phe Lys Gln His Met 
            500                 505                 510         


Gln Asn Gln Ser Asp Ser Gly Pro Ile Asp Leu Thr Val Asn Ile Leu 
        515                 520                 525             


Thr Met Gly Tyr Trp Pro Thr Tyr Thr Pro Met Glu Val His Leu Thr 
    530                 535                 540                 


Pro Glu Met Ile Lys Leu Gln Glu Val Phe Lys Ala Phe Tyr Leu Gly 
545                 550                 555                 560 


Lys His Ser Gly Arg Lys Leu Gln Trp Gln Thr Thr Leu Gly His Ala 
                565                 570                 575     


Val Leu Lys Ala Glu Phe Lys Glu Gly Lys Lys Glu Phe Gln Val Ser 
            580                 585                 590         


Leu Phe Gln Thr Leu Val Leu Leu Met Phe Asn Glu Gly Asp Gly Phe 
        595                 600                 605             


Ser Phe Glu Glu Ile Lys Met Ala Thr Gly Ile Glu Asp Ser Glu Leu 
    610                 615                 620                 


Arg Arg Thr Leu Gln Ser Leu Ala Cys Gly Lys Ala Arg Val Leu Ile 
625                 630                 635                 640 


Lys Ser Pro Lys Gly Lys Glu Val Glu Asp Gly Asp Lys Phe Ile Phe 
                645                 650                 655     


Asn Gly Glu Phe Lys His Lys Leu Phe Arg Ile Lys Ile Asn Gln Ile 
            660                 665                 670         


Gln Met Lys Glu Thr Val Glu Glu Gln Val Ser Thr Thr Glu Arg Val 
        675                 680                 685             


Phe Gln Asp Arg Gln Tyr Gln Ile Asp Ala Ala Ile Val Arg Ile Met 
    690                 695                 700                 


Lys Met Arg Lys Thr Leu Gly His Asn Leu Leu Val Ser Glu Leu Tyr 
705                 710                 715                 720 


Asn Gln Leu Lys Phe Pro Val Lys Pro Gly Asp Leu Lys Lys Arg Ile 
                725                 730                 735     


Glu Ser Leu Ile Asp Arg Asp Tyr Met Glu Arg Asp Lys Asp Asn Pro 
            740                 745                 750         


Asn Gln Tyr His Tyr Val Ala 
        755                 


<210>  2739
<211>  895
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL4B__Homo_sapiens__NP_001073341

<400>  2739

Met Phe Pro Thr Gly Phe Ser Ser Pro Ser Pro Ser Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gln Glu Val Arg Ser Ala Thr Asp Gly Asn Thr Ser Thr Thr Pro 
            20                  25                  30          


Pro Thr Ser Ala Lys Lys Arg Lys Leu Asn Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Asn Ser Ser Asn Glu Arg Glu Asp Phe Asp Ser Thr Ser Ser Ser 
    50                  55                  60                  


Ser Ser Thr Pro Pro Leu Gln Pro Arg Asp Ser Ala Ser Pro Ser Thr 
65                  70                  75                  80  


Ser Ser Phe Cys Leu Gly Val Ser Val Ala Ala Ser Ser His Val Pro 
                85                  90                  95      


Ile Gln Lys Lys Leu Arg Phe Glu Asp Thr Leu Glu Phe Val Gly Phe 
            100                 105                 110         


Asp Ala Lys Met Ala Glu Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Pro Thr Ala Ala Thr Ser Gln Gln Gln Gln Leu Lys Asn Lys Ser Ile 
    130                 135                 140                 


Leu Ile Ser Ser Val Ala Ser Val His His Ala Asn Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Ser Thr Thr Val Ser Ser Phe Ala Asn Ser Lys Pro Gly Ser Ala 
                165                 170                 175     


Lys Lys Leu Val Ile Lys Asn Phe Lys Asp Lys Pro Lys Leu Pro Glu 
            180                 185                 190         


Asn Tyr Thr Asp Glu Thr Trp Gln Lys Leu Lys Glu Ala Val Glu Ala 
        195                 200                 205             


Ile Gln Asn Ser Thr Ser Ile Lys Tyr Asn Leu Glu Glu Leu Tyr Gln 
    210                 215                 220                 


Ala Val Glu Asn Leu Cys Ser Tyr Lys Ile Ser Ala Asn Leu Tyr Lys 
225                 230                 235                 240 


Gln Leu Arg Gln Ile Cys Glu Asp His Ile Lys Ala Gln Ile His Gln 
                245                 250                 255     


Phe Arg Glu Asp Ser Leu Asp Ser Val Leu Phe Leu Lys Lys Ile Asp 
            260                 265                 270         


Arg Cys Trp Gln Asn His Cys Arg Gln Met Ile Met Ile Arg Ser Ile 
        275                 280                 285             


Phe Leu Phe Leu Asp Arg Thr Tyr Val Leu Gln Asn Ser Met Leu Pro 
    290                 295                 300                 


Ser Ile Trp Asp Met Gly Leu Glu Leu Phe Arg Ala His Ile Ile Ser 
305                 310                 315                 320 


Asp Gln Lys Val Gln Asn Lys Thr Ile Asp Gly Ile Leu Leu Leu Ile 
                325                 330                 335     


Glu Arg Glu Arg Asn Gly Glu Ala Ile Asp Arg Ser Leu Leu Arg Ser 
            340                 345                 350         


Leu Leu Ser Met Leu Ser Asp Leu Gln Ile Tyr Gln Asp Ser Phe Glu 
        355                 360                 365             


Gln Arg Phe Leu Glu Glu Thr Asn Arg Leu Tyr Ala Ala Glu Gly Gln 
    370                 375                 380                 


Lys Leu Met Gln Glu Arg Glu Val Pro Glu Tyr Leu His His Val Asn 
385                 390                 395                 400 


Lys Arg Leu Glu Glu Glu Ala Asp Arg Leu Ile Thr Tyr Leu Asp Gln 
                405                 410                 415     


Thr Thr Gln Lys Ser Leu Ile Ala Thr Val Glu Lys Gln Leu Leu Gly 
            420                 425                 430         


Glu His Leu Thr Ala Ile Leu Gln Lys Gly Leu Asn Asn Leu Leu Asp 
        435                 440                 445             


Glu Asn Arg Ile Gln Asp Leu Ser Leu Leu Tyr Gln Leu Phe Ser Arg 
    450                 455                 460                 


Val Arg Gly Gly Val Gln Val Leu Leu Gln Gln Trp Ile Glu Tyr Ile 
465                 470                 475                 480 


Lys Ala Phe Gly Ser Thr Ile Val Ile Asn Pro Glu Lys Asp Lys Thr 
                485                 490                 495     


Met Val Gln Glu Leu Leu Asp Phe Lys Asp Lys Val Asp His Ile Ile 
            500                 505                 510         


Asp Ile Cys Phe Leu Lys Asn Glu Lys Phe Ile Asn Ala Met Lys Glu 
        515                 520                 525             


Ala Phe Glu Thr Phe Ile Asn Lys Arg Pro Asn Lys Pro Ala Glu Leu 
    530                 535                 540                 


Ile Ala Lys Tyr Val Asp Ser Lys Leu Arg Ala Gly Asn Lys Glu Ala 
545                 550                 555                 560 


Thr Asp Glu Glu Leu Glu Lys Met Leu Asp Lys Ile Met Ile Ile Phe 
                565                 570                 575     


Arg Phe Ile Tyr Gly Lys Asp Val Phe Glu Ala Phe Tyr Lys Lys Asp 
            580                 585                 590         


Leu Ala Lys Arg Leu Leu Val Gly Lys Ser Ala Ser Val Asp Ala Glu 
        595                 600                 605             


Lys Ser Met Leu Ser Lys Leu Lys His Glu Cys Gly Ala Ala Phe Thr 
    610                 615                 620                 


Ser Lys Leu Glu Gly Met Phe Lys Asp Met Glu Leu Ser Lys Asp Ile 
625                 630                 635                 640 


Met Ile Gln Phe Lys Gln Tyr Met Gln Asn Gln Asn Val Pro Gly Asn 
                645                 650                 655     


Ile Glu Leu Thr Val Asn Ile Leu Thr Met Gly Tyr Trp Pro Thr Tyr 
            660                 665                 670         


Val Pro Met Glu Val His Leu Pro Pro Glu Met Val Lys Leu Gln Glu 
        675                 680                 685             


Ile Phe Lys Thr Phe Tyr Leu Gly Lys His Ser Gly Arg Lys Leu Gln 
    690                 695                 700                 


Trp Gln Ser Thr Leu Gly His Cys Val Leu Lys Ala Glu Phe Lys Glu 
705                 710                 715                 720 


Gly Lys Lys Glu Leu Gln Val Ser Leu Phe Gln Thr Leu Val Leu Leu 
                725                 730                 735     


Met Phe Asn Glu Gly Glu Glu Phe Ser Leu Glu Glu Ile Lys Gln Ala 
            740                 745                 750         


Thr Gly Ile Glu Asp Gly Glu Leu Arg Arg Thr Leu Gln Ser Leu Ala 
        755                 760                 765             


Cys Gly Lys Ala Arg Val Leu Ala Lys Asn Pro Lys Gly Lys Asp Ile 
    770                 775                 780                 


Glu Asp Gly Asp Lys Phe Ile Cys Asn Asp Asp Phe Lys His Lys Leu 
785                 790                 795                 800 


Phe Arg Ile Lys Ile Asn Gln Ile Gln Met Lys Glu Thr Val Glu Glu 
                805                 810                 815     


Gln Ala Ser Thr Thr Glu Arg Val Phe Gln Asp Arg Gln Tyr Gln Ile 
            820                 825                 830         


Asp Ala Ala Ile Val Arg Ile Met Lys Met Arg Lys Thr Leu Ser His 
        835                 840                 845             


Asn Leu Leu Val Ser Glu Val Tyr Asn Gln Leu Lys Phe Pro Val Lys 
    850                 855                 860                 


Pro Ala Asp Leu Lys Lys Arg Ile Glu Ser Leu Ile Asp Arg Asp Tyr 
865                 870                 875                 880 


Met Glu Arg Asp Lys Glu Asn Pro Asn Gln Tyr Asn Tyr Ile Ala 
                885                 890                 895 


<210>  2740
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL5__Homo_sapiens__NP_003469

<400>  2740

Met Ala Thr Ser Asn Leu Leu Lys Asn Lys Gly Ser Leu Gln Phe Glu 
1               5                   10                  15      


Asp Lys Trp Asp Phe Met Arg Pro Ile Val Leu Lys Leu Leu Arg Gln 
            20                  25                  30          


Glu Ser Val Thr Lys Gln Gln Trp Phe Asp Leu Phe Ser Asp Val His 
        35                  40                  45              


Ala Val Cys Leu Trp Asp Asp Lys Gly Pro Ala Lys Ile His Gln Ala 
    50                  55                  60                  


Leu Lys Glu Asp Ile Leu Glu Phe Ile Lys Gln Ala Gln Ala Arg Val 
65                  70                  75                  80  


Leu Ser His Gln Asp Asp Thr Ala Leu Leu Lys Ala Tyr Ile Val Glu 
                85                  90                  95      


Trp Arg Lys Phe Phe Thr Gln Cys Asp Ile Leu Pro Lys Pro Phe Cys 
            100                 105                 110         


Gln Leu Glu Ile Thr Leu Met Gly Lys Gln Gly Ser Asn Lys Lys Ser 
        115                 120                 125             


Asn Val Glu Asp Ser Ile Val Arg Lys Leu Met Leu Asp Thr Trp Asn 
    130                 135                 140                 


Glu Ser Ile Phe Ser Asn Ile Lys Asn Arg Leu Gln Asp Ser Ala Met 
145                 150                 155                 160 


Lys Leu Val His Ala Glu Arg Leu Gly Glu Ala Phe Asp Ser Gln Leu 
                165                 170                 175     


Val Ile Gly Val Arg Glu Ser Tyr Val Asn Leu Cys Ser Asn Pro Glu 
            180                 185                 190         


Asp Lys Leu Gln Ile Tyr Arg Asp Asn Phe Glu Lys Ala Tyr Leu Asp 
        195                 200                 205             


Ser Thr Glu Arg Phe Tyr Arg Thr Gln Ala Pro Ser Tyr Leu Gln Gln 
    210                 215                 220                 


Asn Gly Val Gln Asn Tyr Met Lys Tyr Ala Asp Ala Lys Leu Lys Glu 
225                 230                 235                 240 


Glu Glu Lys Arg Ala Leu Arg Tyr Leu Glu Thr Arg Arg Glu Cys Asn 
                245                 250                 255     


Ser Val Glu Ala Leu Met Glu Cys Cys Val Asn Ala Leu Val Thr Ser 
            260                 265                 270         


Phe Lys Glu Thr Ile Leu Ala Glu Cys Gln Gly Met Ile Lys Arg Asn 
        275                 280                 285             


Glu Thr Glu Lys Leu His Leu Met Phe Ser Leu Met Asp Lys Val Pro 
    290                 295                 300                 


Asn Gly Ile Glu Pro Met Leu Lys Asp Leu Glu Glu His Ile Ile Ser 
305                 310                 315                 320 


Ala Gly Leu Ala Asp Met Val Ala Ala Ala Glu Thr Ile Thr Thr Asp 
                325                 330                 335     


Ser Glu Lys Tyr Val Glu Gln Leu Leu Thr Leu Phe Asn Arg Phe Ser 
            340                 345                 350         


Lys Leu Val Lys Glu Ala Phe Gln Asp Asp Pro Arg Phe Leu Thr Ala 
        355                 360                 365             


Arg Asp Lys Ala Tyr Lys Ala Val Val Asn Asp Ala Thr Ile Phe Lys 
    370                 375                 380                 


Leu Glu Leu Pro Leu Lys Gln Lys Gly Val Gly Leu Lys Thr Gln Pro 
385                 390                 395                 400 


Glu Ser Lys Cys Pro Glu Leu Leu Ala Asn Tyr Cys Asp Met Leu Leu 
                405                 410                 415     


Arg Lys Thr Pro Leu Ser Lys Lys Leu Thr Ser Glu Glu Ile Glu Ala 
            420                 425                 430         


Lys Leu Lys Glu Val Leu Leu Val Leu Lys Tyr Val Gln Asn Lys Asp 
        435                 440                 445             


Val Phe Met Arg Tyr His Lys Ala His Leu Thr Arg Arg Leu Ile Leu 
    450                 455                 460                 


Asp Ile Ser Ala Asp Ser Glu Ile Glu Glu Asn Met Val Glu Trp Leu 
465                 470                 475                 480 


Arg Glu Val Gly Met Pro Ala Asp Tyr Val Asn Lys Leu Ala Arg Met 
                485                 490                 495     


Phe Gln Asp Ile Lys Val Ser Glu Asp Leu Asn Gln Ala Phe Lys Glu 
            500                 505                 510         


Met His Lys Asn Asn Lys Leu Ala Leu Pro Ala Asp Ser Val Asn Ile 
        515                 520                 525             


Lys Ile Leu Asn Ala Gly Ala Trp Ser Arg Ser Ser Glu Lys Val Phe 
    530                 535                 540                 


Val Ser Leu Pro Thr Glu Leu Glu Asp Leu Ile Pro Glu Val Glu Glu 
545                 550                 555                 560 


Phe Tyr Lys Lys Asn His Ser Gly Arg Lys Leu His Trp His His Leu 
                565                 570                 575     


Met Ser Asn Gly Ile Ile Thr Phe Lys Asn Glu Val Gly Gln Tyr Asp 
            580                 585                 590         


Leu Glu Val Thr Thr Phe Gln Leu Ala Val Leu Phe Ala Trp Asn Gln 
        595                 600                 605             


Arg Pro Arg Glu Lys Ile Ser Phe Glu Asn Leu Lys Leu Ala Thr Glu 
    610                 615                 620                 


Leu Pro Asp Ala Glu Leu Arg Arg Thr Leu Trp Ser Leu Val Ala Phe 
625                 630                 635                 640 


Pro Lys Leu Lys Arg Gln Val Leu Leu Tyr Glu Pro Gln Val Asn Ser 
                645                 650                 655     


Pro Lys Asp Phe Thr Glu Gly Thr Leu Phe Ser Val Asn Gln Glu Phe 
            660                 665                 670         


Ser Leu Ile Lys Asn Ala Lys Val Gln Lys Arg Gly Lys Ile Asn Leu 
        675                 680                 685             


Ile Gly Arg Leu Gln Leu Thr Thr Glu Arg Met Arg Glu Glu Glu Asn 
    690                 695                 700                 


Glu Gly Ile Val Gln Leu Arg Ile Leu Arg Thr Gln Glu Ala Ile Ile 
705                 710                 715                 720 


Gln Ile Met Lys Met Arg Lys Lys Ile Ser Asn Ala Gln Leu Gln Thr 
                725                 730                 735     


Glu Leu Val Glu Ile Leu Lys Asn Met Phe Leu Pro Gln Lys Lys Met 
            740                 745                 750         


Ile Lys Glu Gln Ile Glu Trp Leu Ile Glu His Lys Tyr Ile Arg Arg 
        755                 760                 765             


Asp Glu Ser Asp Ile Asn Thr Phe Ile Tyr Met Ala 
    770                 775                 780 


<210>  2741
<211>  1782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL7__Homo_sapiens__NP_001161842

<400>  2741

Met Ser Arg Gly Phe Trp Leu Ala Glu Pro Leu Ala Gly Thr Gly Pro 
1               5                   10                  15      


His Pro Ala Pro Val Ala Ala Asp Ser Arg Gly Cys Ser Ser Val Pro 
            20                  25                  30          


Arg Arg His Ala Pro Ser Arg Leu Ser Val Ser Thr Pro Ser Arg Gly 
        35                  40                  45              


Pro Gly Ala Arg Met Val Gly Glu Leu Arg Tyr Arg Glu Phe Arg Val 
    50                  55                  60                  


Pro Leu Gly Pro Gly Leu His Ala Tyr Pro Asp Glu Leu Ile Arg Gln 
65                  70                  75                  80  


Arg Val Gly His Asp Gly His Pro Glu Tyr Gln Ile Arg Trp Leu Ile 
                85                  90                  95      


Leu Arg Arg Gly Asp Glu Gly Asp Gly Gly Ser Gly Gln Val Asp Cys 
            100                 105                 110         


Lys Ala Glu His Ile Leu Leu Trp Met Ser Lys Asp Glu Ile Tyr Ala 
        115                 120                 125             


Asn Cys His Lys Met Leu Gly Glu Asp Gly Gln Val Ile Gly Pro Ser 
    130                 135                 140                 


Gln Glu Ser Ala Gly Glu Val Gly Ala Leu Asp Lys Ser Val Leu Glu 
145                 150                 155                 160 


Glu Met Glu Thr Asp Val Lys Ser Leu Ile Gln Arg Ala Leu Arg Gln 
                165                 170                 175     


Leu Glu Glu Cys Val Gly Thr Ile Pro Pro Ala Pro Leu Leu His Thr 
            180                 185                 190         


Val His Val Leu Ser Ala Tyr Ala Ser Ile Glu Pro Leu Thr Gly Val 
        195                 200                 205             


Phe Lys Asp Pro Arg Val Leu Asp Leu Leu Met His Met Leu Ser Ser 
    210                 215                 220                 


Pro Asp Tyr Gln Ile Arg Trp Ser Ala Gly Arg Met Ile Gln Ala Leu 
225                 230                 235                 240 


Ser Ser His Asp Ala Gly Glu Gly Gln Cys Gly Glu Glu Gly Lys Ala 
                245                 250                 255     


Gly Glu Gly Leu Gly Arg Leu Arg Asp Ser Gln Asp Thr Val Ala Gly 
            260                 265                 270         


Ala Ser Asp Leu Ile Arg Thr Arg Thr Gln Ile Leu Leu Ser Leu Ser 
        275                 280                 285             


Gln Gln Glu Ala Ile Glu Lys His Leu Asp Phe Asp Ser Arg Cys Ala 
    290                 295                 300                 


Leu Leu Ala Leu Phe Ala Gln Ala Thr Leu Ser Glu His Pro Met Ser 
305                 310                 315                 320 


Phe Glu Gly Ile Gln Leu Pro Gln Val Pro Gly Arg Val Leu Phe Ser 
                325                 330                 335     


Leu Val Lys Arg Tyr Leu His Val Thr Ser Leu Leu Asp Gln Leu Asn 
            340                 345                 350         


Asp Ser Ala Ala Glu Pro Gly Ala Gln Asn Thr Ser Ala Pro Glu Glu 
        355                 360                 365             


Leu Ser Gly Glu Arg Gly Gln Leu Glu Leu Glu Phe Ser Met Ala Met 
    370                 375                 380                 


Gly Thr Leu Ile Ser Glu Leu Val Gln Ala Met Arg Trp Asp Gln Ala 
385                 390                 395                 400 


Ser Asp Arg Pro Arg Ser Ser Ala Arg Ser Pro Gly Ser Ile Phe Gln 
                405                 410                 415     


Pro Gln Leu Ala Asp Val Ser Pro Gly Leu Pro Ala Ala Gln Ala Gln 
            420                 425                 430         


Pro Ser Phe Arg Arg Ser Arg Arg Phe Arg Pro Arg Ser Glu Phe Ala 
        435                 440                 445             


Ser Gly Asn Thr Tyr Ala Leu Tyr Val Arg Asp Thr Leu Gln Pro Gly 
    450                 455                 460                 


Met Arg Val Arg Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala Gly Asp 
465                 470                 475                 480 


Glu Gly Glu Phe Arg Gln Ser Asn Asn Gly Val Pro Pro Val Gln Val 
                485                 490                 495     


Phe Trp Glu Ser Thr Gly Arg Thr Tyr Trp Val His Trp His Met Leu 
            500                 505                 510         


Glu Ile Leu Gly Phe Glu Glu Asp Ile Glu Asp Met Val Glu Ala Asp 
        515                 520                 525             


Glu Tyr Gln Gly Ala Val Ala Ser Arg Val Leu Gly Arg Ala Leu Pro 
    530                 535                 540                 


Ala Trp Arg Trp Arg Pro Met Thr Glu Leu Tyr Ala Val Pro Tyr Val 
545                 550                 555                 560 


Leu Pro Glu Asp Glu Asp Thr Glu Glu Cys Glu His Leu Thr Leu Ala 
                565                 570                 575     


Glu Trp Trp Glu Leu Leu Phe Phe Ile Lys Lys Leu Asp Gly Pro Asp 
            580                 585                 590         


His Gln Glu Val Leu Gln Ile Leu Gln Glu Asn Leu Asp Gly Glu Ile 
        595                 600                 605             


Leu Asp Asp Glu Ile Leu Ala Glu Leu Ala Val Pro Ile Glu Leu Ala 
    610                 615                 620                 


Gln Asp Leu Leu Leu Thr Leu Pro Gln Arg Leu Asn Asp Ser Ala Leu 
625                 630                 635                 640 


Arg Asp Leu Ile Asn Cys His Val Tyr Lys Lys Tyr Gly Pro Glu Ala 
                645                 650                 655     


Leu Ala Gly Asn Gln Ala Tyr Pro Ser Leu Leu Glu Ala Gln Glu Asp 
            660                 665                 670         


Val Leu Leu Leu Asp Ala Gln Ala Gln Ala Lys Asp Ser Glu Asp Ala 
        675                 680                 685             


Ala Lys Val Glu Ala Lys Glu Pro Pro Ser Gln Ser Pro Asn Thr Pro 
    690                 695                 700                 


Leu Gln Arg Leu Val Glu Gly Tyr Gly Pro Ala Gly Lys Ile Leu Leu 
705                 710                 715                 720 


Asp Leu Glu Gln Ala Leu Ser Ser Glu Gly Thr Gln Glu Asn Lys Val 
                725                 730                 735     


Lys Pro Leu Leu Leu Gln Leu Gln Arg Gln Pro Gln Pro Phe Leu Ala 
            740                 745                 750         


Leu Met Gln Ser Leu Asp Thr Pro Glu Thr Asn Arg Thr Leu His Leu 
        755                 760                 765             


Thr Val Leu Arg Ile Leu Lys Gln Leu Val Asp Phe Pro Glu Ala Leu 
    770                 775                 780                 


Leu Leu Pro Trp His Glu Ala Val Asp Ala Cys Met Ala Cys Leu Arg 
785                 790                 795                 800 


Ser Pro Asn Thr Asp Arg Glu Val Leu Gln Glu Leu Ile Phe Phe Leu 
                805                 810                 815     


His Arg Leu Thr Ser Val Ser Arg Asp Tyr Ala Val Val Leu Asn Gln 
            820                 825                 830         


Leu Gly Ala Arg Asp Ala Ile Ser Lys Ala Leu Glu Lys His Leu Gly 
        835                 840                 845             


Lys Leu Glu Leu Ala Gln Glu Leu Arg Asp Met Val Phe Lys Cys Glu 
    850                 855                 860                 


Lys His Ala His Leu Tyr Arg Lys Leu Ile Thr Asn Ile Leu Gly Gly 
865                 870                 875                 880 


Cys Ile Gln Met Val Leu Gly Gln Ile Glu Asp His Arg Arg Thr His 
                885                 890                 895     


Gln Pro Ile Asn Ile Pro Phe Phe Asp Val Phe Leu Arg Tyr Leu Cys 
            900                 905                 910         


Gln Gly Ser Ser Val Glu Val Lys Glu Asp Lys Cys Trp Glu Lys Val 
        915                 920                 925             


Glu Val Ser Ser Asn Pro His Arg Ala Ser Lys Leu Thr Asp His Asn 
    930                 935                 940                 


Pro Lys Thr Tyr Trp Glu Ser Asn Gly Ser Ala Gly Ser His Tyr Ile 
945                 950                 955                 960 


Thr Leu His Met Arg Arg Gly Ile Leu Ile Arg Gln Leu Thr Leu Leu 
                965                 970                 975     


Val Ala Ser Glu Asp Ser Ser Tyr Met Pro Ala Arg Val Val Val Cys 
            980                 985                 990         


Gly Gly Asp Ser Thr Ser Ser Leu  His Thr Glu Leu Asn  Ser Val Asn 
        995                 1000                 1005             


Val Met  Pro Ser Ala Ser Arg  Val Ile Leu Leu Glu  Asn Leu Thr 
    1010                 1015                 1020             


Arg Phe  Trp Pro Ile Ile Gln  Ile Arg Ile Lys Arg  Cys Gln Gln 
    1025                 1030                 1035             


Gly Gly  Ile Asp Thr Arg Ile  Arg Gly Leu Glu Ile  Leu Gly Pro 
    1040                 1045                 1050             


Lys Pro  Thr Phe Trp Pro Val  Phe Arg Glu Gln Leu  Cys Arg His 
    1055                 1060                 1065             


Thr Arg  Leu Phe Tyr Met Val  Arg Ala Gln Ala Trp  Ser Gln Asp 
    1070                 1075                 1080             


Met Ala  Glu Asp Arg Arg Ser  Leu Leu His Leu Ser  Ser Arg Leu 
    1085                 1090                 1095             


Asn Gly  Ala Leu Arg Gln Glu  Gln Asn Phe Ala Asp  Arg Phe Leu 
    1100                 1105                 1110             


Pro Asp  Asp Glu Ala Ala Gln  Ala Leu Gly Lys Thr  Cys Trp Glu 
    1115                 1120                 1125             


Ala Leu  Val Ser Pro Val Val  Gln Asn Ile Thr Ser  Pro Asp Glu 
    1130                 1135                 1140             


Asp Gly  Ile Ser Pro Leu Gly  Trp Leu Leu Asp Gln  Tyr Leu Glu 
    1145                 1150                 1155             


Cys Gln  Glu Ala Val Phe Asn  Pro Gln Ser Arg Gly  Pro Ala Phe 
    1160                 1165                 1170             


Phe Ser  Arg Val Arg Arg Leu  Thr His Leu Leu Val  His Val Glu 
    1175                 1180                 1185             


Pro Cys  Glu Ala Pro Pro Pro  Val Val Ala Thr Pro  Arg Pro Lys 
    1190                 1195                 1200             


Gly Arg  Asn Arg Ser His Asp  Trp Ser Ser Leu Ala  Thr Arg Gly 
    1205                 1210                 1215             


Leu Pro  Ser Ser Ile Met Arg  Asn Leu Thr Arg Cys  Trp Arg Ala 
    1220                 1225                 1230             


Val Val  Glu Lys Gln Val Asn  Asn Phe Leu Thr Ser  Ser Trp Arg 
    1235                 1240                 1245             


Asp Asp  Asp Phe Val Pro Arg  Tyr Cys Glu His Phe  Asn Ile Leu 
    1250                 1255                 1260             


Gln Asn  Ser Ser Ser Glu Leu  Phe Gly Pro Arg Ala  Ala Phe Leu 
    1265                 1270                 1275             


Leu Ala  Leu Gln Asn Gly Cys  Ala Gly Ala Leu Leu  Lys Leu Pro 
    1280                 1285                 1290             


Phe Leu  Lys Ala Ala His Val  Ser Glu Gln Phe Ala  Arg His Ile 
    1295                 1300                 1305             


Asp Gln  Gln Ile Gln Gly Ser  Arg Ile Gly Gly Ala  Gln Glu Met 
    1310                 1315                 1320             


Glu Arg  Leu Ala Gln Leu Gln  Gln Cys Leu Gln Ala  Val Leu Ile 
    1325                 1330                 1335             


Phe Ser  Gly Leu Glu Ile Ala  Thr Thr Phe Glu His  Tyr Tyr Gln 
    1340                 1345                 1350             


His Tyr  Met Ala Asp Arg Leu  Leu Gly Val Val Ser  Ser Trp Leu 
    1355                 1360                 1365             


Glu Gly  Ala Val Leu Glu Gln  Ile Gly Pro Cys Phe  Pro Asn Arg 
    1370                 1375                 1380             


Leu Pro  Gln Gln Met Leu Gln  Ser Leu Ser Thr Ser  Lys Glu Leu 
    1385                 1390                 1395             


Gln Arg  Gln Phe His Val Tyr  Gln Leu Gln Gln Leu  Asp Gln Glu 
    1400                 1405                 1410             


Leu Leu  Lys Leu Glu Asp Thr  Glu Lys Lys Ile Gln  Val Gly Leu 
    1415                 1420                 1425             


Gly Ala  Ser Gly Lys Glu His  Lys Ser Glu Lys Glu  Glu Glu Ala 
    1430                 1435                 1440             


Gly Ala  Ala Ala Val Val Asp  Val Ala Glu Gly Glu  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Asn Glu Asp Leu Tyr  Tyr Glu Gly Ala Met  Pro Glu Val 
    1460                 1465                 1470             


Ser Val  Leu Val Leu Ser Arg  His Ser Trp Pro Val  Ala Ser Ile 
    1475                 1480                 1485             


Cys His  Thr Leu Asn Pro Arg  Thr Cys Leu Pro Ser  Tyr Leu Arg 
    1490                 1495                 1500             


Gly Thr  Leu Asn Arg Tyr Ser  Asn Phe Tyr Asn Lys  Ser Gln Ser 
    1505                 1510                 1515             


His Pro  Ala Leu Glu Arg Gly  Ser Gln Arg Arg Leu  Gln Trp Thr 
    1520                 1525                 1530             


Trp Leu  Gly Trp Ala Glu Leu  Gln Phe Gly Asn Gln  Thr Leu His 
    1535                 1540                 1545             


Val Ser  Thr Val Gln Met Trp  Leu Leu Leu Tyr Leu  Asn Asp Leu 
    1550                 1555                 1560             


Lys Ala  Val Ser Val Glu Ser  Leu Leu Ala Phe Ser  Gly Leu Ser 
    1565                 1570                 1575             


Ala Asp  Met Leu Asn Gln Ala  Ile Gly Pro Leu Thr  Ser Ser Arg 
    1580                 1585                 1590             


Gly Pro  Leu Asp Leu His Glu  Gln Lys Asp Ile Pro  Gly Gly Val 
    1595                 1600                 1605             


Leu Lys  Ile Arg Asp Gly Ser  Lys Glu Pro Arg Ser  Arg Trp Asp 
    1610                 1615                 1620             


Ile Val  Arg Leu Ile Pro Pro  Gln Thr Tyr Leu Gln  Ala Glu Gly 
    1625                 1630                 1635             


Glu Asp  Gly Gln Asn Leu Glu  Lys Arg Arg Asn Leu  Leu Asn Cys 
    1640                 1645                 1650             


Leu Ile  Val Arg Ile Leu Lys  Ala His Gly Asp Glu  Gly Leu His 
    1655                 1660                 1665             


Ile Asp  Gln Leu Val Cys Leu  Val Leu Glu Ala Trp  Gln Lys Gly 
    1670                 1675                 1680             


Pro Cys  Pro Pro Arg Gly Leu  Val Ser Ser Leu Gly  Lys Gly Ser 
    1685                 1690                 1695             


Ala Cys  Ser Ser Thr Asp Val  Leu Ser Cys Ile Leu  His Leu Leu 
    1700                 1705                 1710             


Gly Lys  Gly Thr Leu Arg Arg  His Asp Asp Arg Pro  Gln Val Leu 
    1715                 1720                 1725             


Ser Tyr  Ala Val Pro Val Thr  Val Met Glu Pro His  Thr Glu Ser 
    1730                 1735                 1740             


Leu Asn  Pro Gly Ser Ser Gly  Pro Asn Pro Pro Leu  Thr Phe His 
    1745                 1750                 1755             


Thr Leu  Gln Ile Arg Ser Arg  Gly Val Pro Tyr Ala  Ser Cys Thr 
    1760                 1765                 1770             


Ala Thr  Gln Ser Phe Ser Thr  Phe Arg 
    1775                 1780         


<210>  2742
<211>  2517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUL9__Homo_sapiens__NP_055904

<400>  2742

Met Val Gly Glu Arg His Ala Gly Asp Leu Met Val Pro Leu Gly Pro 
1               5                   10                  15      


Arg Leu Gln Ala Tyr Pro Glu Glu Leu Ile Arg Gln Arg Pro Gly His 
            20                  25                  30          


Asp Gly His Pro Glu Tyr Leu Ile Arg Trp Ser Val Leu Lys Cys Gly 
        35                  40                  45              


Glu Val Gly Lys Val Gly Val Glu Glu Gly Lys Ala Glu His Ile Leu 
    50                  55                  60                  


Met Trp Leu Ser Ala Pro Glu Val Tyr Ala Asn Cys Pro Gly Leu Leu 
65                  70                  75                  80  


Gly Glu Arg Ala Leu Ser Lys Gly Leu Gln His Glu Pro Ala Gly Val 
                85                  90                  95      


Ser Gly Ser Phe Pro Arg Asp Pro Gly Gly Leu Asp Glu Val Ala Met 
            100                 105                 110         


Gly Glu Met Glu Ala Asp Val Gln Ala Leu Val Arg Arg Ala Ala Arg 
        115                 120                 125             


Gln Leu Ala Glu Ser Gly Thr Pro Ser Leu Thr Ala Ala Val Leu His 
    130                 135                 140                 


Thr Ile His Val Leu Ser Ala Tyr Ala Ser Ile Gly Pro Leu Thr Gly 
145                 150                 155                 160 


Val Phe Arg Glu Thr Gly Ala Leu Asp Leu Leu Met His Met Leu Cys 
                165                 170                 175     


Asn Pro Glu Pro Gln Ile Arg Arg Ser Ala Gly Lys Met Leu Gln Ala 
            180                 185                 190         


Leu Ala Ala His Asp Ala Gly Ser Arg Ala His Val Leu Leu Ser Leu 
        195                 200                 205             


Ser Gln Gln Asp Gly Ile Glu Gln His Met Asp Phe Asp Ser Arg Tyr 
    210                 215                 220                 


Thr Leu Leu Glu Leu Phe Ala Glu Thr Thr Ser Ser Glu Glu His Cys 
225                 230                 235                 240 


Met Ala Phe Glu Gly Ile His Leu Pro Gln Ile Pro Gly Lys Leu Leu 
                245                 250                 255     


Phe Ser Leu Val Lys Arg Tyr Leu Cys Val Thr Ser Leu Leu Asp Gln 
            260                 265                 270         


Leu Asn Ser Ser Pro Glu Leu Gly Ala Gly Asp Gln Ser Ser Pro Cys 
        275                 280                 285             


Ala Thr Arg Glu Lys Ser Arg Gly Gln Arg Glu Leu Glu Phe Ser Met 
    290                 295                 300                 


Ala Val Gly Asn Leu Ile Ser Glu Leu Val Arg Ser Met Gly Trp Ala 
305                 310                 315                 320 


Arg Asn Leu Ser Glu Gln Gly Met Ser Pro Pro Arg Pro Thr Arg Ser 
                325                 330                 335     


Ile Phe Gln Pro Tyr Ile Ser Gly Pro Ser Leu Leu Leu Pro Thr Ile 
            340                 345                 350         


Val Thr Thr Pro Arg Arg Gln Gly Trp Val Phe Arg Gln Arg Ser Glu 
        355                 360                 365             


Phe Ser Ser Arg Ser Gly Tyr Gly Glu Tyr Val Gln Gln Thr Leu Gln 
    370                 375                 380                 


Pro Gly Met Arg Val Arg Met Leu Asp Asp Tyr Glu Glu Ile Ser Ala 
385                 390                 395                 400 


Gly Asp Glu Gly Glu Phe Arg Gln Ser Asn Asn Gly Ile Pro Pro Val 
                405                 410                 415     


Gln Val Phe Trp Gln Ser Thr Gly Arg Thr Tyr Trp Val His Trp His 
            420                 425                 430         


Met Leu Glu Ile Leu Gly Pro Glu Glu Ala Thr Glu Asp Lys Ala Ser 
        435                 440                 445             


Ala Ala Val Glu Lys Gly Ala Gly Ala Thr Val Leu Gly Thr Ala Phe 
    450                 455                 460                 


Pro Ser Trp Asp Trp Asn Pro Met Asp Gly Leu Tyr Pro Leu Pro Tyr 
465                 470                 475                 480 


Leu Gln Pro Glu Pro Gln Lys Asn Glu Arg Val Gly Tyr Leu Thr Gln 
                485                 490                 495     


Ala Glu Trp Trp Glu Leu Leu Phe Phe Ile Lys Lys Leu Asp Leu Cys 
            500                 505                 510         


Glu Gln Gln Pro Ile Phe Gln Asn Leu Trp Lys Asn Leu Asp Glu Thr 
        515                 520                 525             


Leu Gly Glu Lys Ala Leu Gly Glu Ile Ser Val Ser Val Glu Met Ala 
    530                 535                 540                 


Glu Ser Leu Leu Gln Val Leu Ser Ser Arg Phe Glu Gly Ser Thr Leu 
545                 550                 555                 560 


Asn Asp Leu Leu Asn Ser Gln Ile Tyr Thr Lys Tyr Gly Leu Leu Ser 
                565                 570                 575     


Asn Glu Pro Ser Ser Ser Ser Thr Ser Arg Asn His Ser Cys Thr Pro 
            580                 585                 590         


Asp Pro Glu Glu Glu Ser Lys Ser Glu Ala Ser Phe Ser Glu Glu Glu 
        595                 600                 605             


Thr Glu Ser Leu Lys Ala Lys Ala Glu Ala Pro Lys Thr Glu Ala Glu 
    610                 615                 620                 


Pro Thr Lys Thr Arg Thr Glu Thr Pro Met Ala Gln Ser Asp Ser Gln 
625                 630                 635                 640 


Leu Phe Asn Gln Leu Leu Val Thr Glu Gly Met Thr Leu Pro Thr Glu 
                645                 650                 655     


Met Lys Glu Ala Ala Ser Glu Met Ala Arg Ala Leu Arg Gly Pro Gly 
            660                 665                 670         


Pro Arg Ser Ser Leu Asp Gln His Val Ala Ala Val Val Ala Thr Val 
        675                 680                 685             


Gln Ile Ser Ser Leu Asp Thr Asn Leu Gln Leu Ser Gly Leu Ser Ala 
    690                 695                 700                 


Leu Ser Gln Ala Val Glu Glu Val Thr Glu Arg Asp His Pro Leu Val 
705                 710                 715                 720 


Arg Pro Asp Arg Ser Leu Arg Glu Lys Leu Val Lys Met Leu Val Glu 
                725                 730                 735     


Leu Leu Thr Asn Gln Val Gly Glu Lys Met Val Val Val Gln Ala Leu 
            740                 745                 750         


Arg Leu Leu Tyr Leu Leu Met Thr Lys His Glu Trp Arg Pro Leu Phe 
        755                 760                 765             


Ala Arg Glu Gly Gly Ile Tyr Ala Val Leu Val Cys Met Gln Glu Tyr 
    770                 775                 780                 


Lys Thr Ser Val Leu Val Gln Gln Ala Gly Leu Ala Ala Leu Lys Met 
785                 790                 795                 800 


Leu Ala Val Ala Ser Ser Ser Glu Ile Pro Thr Phe Val Thr Gly Arg 
                805                 810                 815     


Asp Ser Ile His Ser Leu Phe Asp Ala Gln Met Thr Arg Glu Ile Phe 
            820                 825                 830         


Ala Ser Ile Asp Ser Ala Thr Arg Pro Gly Ser Glu Ser Leu Leu Leu 
        835                 840                 845             


Thr Val Pro Ala Ala Val Ile Leu Met Leu Asn Thr Glu Gly Cys Ser 
    850                 855                 860                 


Ser Ala Ala Arg Asn Gly Leu Leu Leu Leu Asn Leu Leu Leu Cys Asn 
865                 870                 875                 880 


His His Thr Leu Gly Asp Gln Ile Ile Thr Gln Glu Leu Arg Asp Thr 
                885                 890                 895     


Leu Phe Arg His Ser Gly Ile Ala Pro Arg Thr Glu Pro Met Pro Thr 
            900                 905                 910         


Thr Arg Thr Ile Leu Met Met Leu Leu Asn Arg Tyr Ser Glu Pro Pro 
        915                 920                 925             


Gly Ser Pro Glu Arg Ala Ala Leu Glu Thr Pro Ile Ile Gln Gly Gln 
    930                 935                 940                 


Asp Gly Ser Pro Glu Leu Leu Ile Arg Ser Leu Val Gly Gly Pro Ser 
945                 950                 955                 960 


Ala Glu Leu Leu Leu Asp Leu Glu Arg Val Leu Cys Arg Glu Gly Ser 
                965                 970                 975     


Pro Gly Gly Ala Val Arg Pro Leu Leu Lys Arg Leu Gln Gln Glu Thr 
            980                 985                 990         


Gln Pro Phe Leu Leu Leu Leu Arg  Thr Leu Asp Ala Pro  Gly Pro Asn 
        995                 1000                 1005             


Lys Thr  Leu Leu Leu Ser Val  Leu Arg Val Ile Thr  Arg Leu Leu 
    1010                 1015                 1020             


Asp Phe  Pro Glu Ala Met Val  Leu Pro Trp His Glu  Val Leu Glu 
    1025                 1030                 1035             


Pro Cys  Leu Asn Cys Leu Ser  Gly Pro Ser Ser Asp  Ser Glu Ile 
    1040                 1045                 1050             


Val Gln  Glu Leu Thr Cys Phe  Leu His Arg Leu Ala  Ser Met His 
    1055                 1060                 1065             


Lys Asp  Tyr Ala Val Val Leu  Cys Cys Leu Gly Ala  Lys Glu Ile 
    1070                 1075                 1080             


Leu Ser  Lys Val Leu Asp Lys  His Ser Ala Gln Leu  Leu Leu Gly 
    1085                 1090                 1095             


Cys Glu  Leu Arg Asp Leu Val  Thr Glu Cys Glu Lys  Tyr Ala Gln 
    1100                 1105                 1110             


Leu Tyr  Ser Asn Leu Thr Ser  Ser Ile Leu Ala Gly  Cys Ile Gln 
    1115                 1120                 1125             


Met Val  Leu Gly Gln Ile Glu  Asp His Arg Arg Thr  His Gln Pro 
    1130                 1135                 1140             


Ile Asn  Ile Pro Phe Phe Asp  Val Phe Leu Arg His  Leu Cys Gln 
    1145                 1150                 1155             


Gly Ser  Ser Val Glu Val Lys  Glu Asp Lys Cys Trp  Glu Lys Val 
    1160                 1165                 1170             


Glu Val  Ser Ser Asn Pro His  Arg Ala Ser Lys Leu  Thr Asp His 
    1175                 1180                 1185             


Asn Pro  Lys Thr Tyr Trp Glu  Ser Asn Gly Ser Thr  Gly Ser His 
    1190                 1195                 1200             


Tyr Ile  Thr Leu His Met His  Arg Gly Val Leu Val  Arg Gln Leu 
    1205                 1210                 1215             


Thr Leu  Leu Val Ala Ser Glu  Asp Ser Ser Tyr Met  Pro Ala Arg 
    1220                 1225                 1230             


Val Val  Val Phe Gly Gly Asp  Ser Thr Ser Cys Ile  Gly Thr Glu 
    1235                 1240                 1245             


Leu Asn  Thr Val Asn Val Met  Pro Ser Ala Ser Arg  Val Ile Leu 
    1250                 1255                 1260             


Leu Glu  Asn Leu Asn Arg Phe  Trp Pro Ile Ile Gln  Ile Arg Ile 
    1265                 1270                 1275             


Lys Arg  Cys Gln Gln Gly Gly  Ile Asp Thr Arg Val  Arg Gly Val 
    1280                 1285                 1290             


Glu Val  Leu Gly Pro Lys Pro  Thr Phe Trp Pro Leu  Phe Arg Glu 
    1295                 1300                 1305             


Gln Leu  Cys Arg Arg Thr Cys  Leu Phe Tyr Thr Ile  Arg Ala Gln 
    1310                 1315                 1320             


Ala Trp  Ser Arg Asp Ile Ala  Glu Asp His Arg Arg  Leu Leu Gln 
    1325                 1330                 1335             


Leu Cys  Pro Arg Leu Asn Arg  Val Leu Arg His Glu  Gln Asn Phe 
    1340                 1345                 1350             


Ala Asp  Arg Phe Leu Pro Asp  Asp Glu Ala Ala Gln  Ala Leu Gly 
    1355                 1360                 1365             


Lys Thr  Cys Trp Glu Ala Leu  Val Ser Pro Leu Val  Gln Asn Ile 
    1370                 1375                 1380             


Thr Ser  Pro Asp Ala Glu Gly  Val Ser Ala Leu Gly  Trp Leu Leu 
    1385                 1390                 1395             


Asp Gln  Tyr Leu Glu Gln Arg  Glu Thr Ser Arg Asn  Pro Leu Ser 
    1400                 1405                 1410             


Arg Ala  Ala Ser Phe Ala Ser  Arg Val Arg Arg Leu  Cys His Leu 
    1415                 1420                 1425             


Leu Val  His Val Glu Pro Pro  Pro Gly Pro Ser Pro  Glu Pro Ser 
    1430                 1435                 1440             


Thr Arg  Pro Phe Ser Lys Asn  Ser Lys Gly Arg Asp  Arg Ser Pro 
    1445                 1450                 1455             


Ala Pro  Ser Pro Val Leu Pro  Ser Ser Ser Leu Arg  Asn Ile Thr 
    1460                 1465                 1470             


Gln Cys  Trp Leu Ser Val Val  Gln Glu Gln Val Ser  Arg Phe Leu 
    1475                 1480                 1485             


Ala Ala  Ala Trp Arg Ala Pro  Asp Phe Val Pro Arg  Tyr Cys Lys 
    1490                 1495                 1500             


Leu Tyr  Glu His Leu Gln Arg  Ala Gly Ser Glu Leu  Phe Gly Pro 
    1505                 1510                 1515             


Arg Ala  Ala Phe Met Leu Ala  Leu Arg Ser Gly Phe  Ser Gly Ala 
    1520                 1525                 1530             


Leu Leu  Gln Gln Ser Phe Leu  Thr Ala Ala His Met  Ser Glu Gln 
    1535                 1540                 1545             


Phe Ala  Arg Tyr Ile Asp Gln  Gln Ile Gln Gly Gly  Leu Ile Gly 
    1550                 1555                 1560             


Gly Ala  Pro Gly Val Glu Met  Leu Gly Gln Leu Gln  Arg His Leu 
    1565                 1570                 1575             


Glu Pro  Ile Met Val Leu Ser  Gly Leu Glu Leu Ala  Thr Thr Phe 
    1580                 1585                 1590             


Glu His  Phe Tyr Gln His Tyr  Met Ala Asp Arg Leu  Leu Ser Phe 
    1595                 1600                 1605             


Gly Ser  Ser Trp Leu Glu Gly  Ala Val Leu Glu Gln  Ile Gly Leu 
    1610                 1615                 1620             


Cys Phe  Pro Asn Arg Leu Pro  Gln Leu Met Leu Gln  Ser Leu Ser 
    1625                 1630                 1635             


Thr Ser  Glu Glu Leu Gln Arg  Gln Phe His Leu Phe  Gln Leu Gln 
    1640                 1645                 1650             


Arg Leu  Asp Lys Leu Phe Leu  Glu Gln Glu Asp Glu  Glu Glu Lys 
    1655                 1660                 1665             


Arg Leu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Glu  Glu Ala Glu 
    1670                 1675                 1680             


Lys Glu  Leu Phe Ile Glu Asp  Pro Ser Pro Ala Ile  Ser Ile Leu 
    1685                 1690                 1695             


Val Leu  Ser Pro Arg Cys Trp  Pro Val Ser Pro Leu  Cys Tyr Leu 
    1700                 1705                 1710             


Tyr His  Pro Arg Lys Cys Leu  Pro Thr Glu Phe Cys  Asp Ala Leu 
    1715                 1720                 1725             


Asp Arg  Phe Ser Ser Phe Tyr  Ser Gln Ser Gln Asn  His Pro Val 
    1730                 1735                 1740             


Leu Asp  Met Gly Pro His Arg  Arg Leu Gln Trp Thr  Trp Leu Gly 
    1745                 1750                 1755             


Arg Ala  Glu Leu Gln Phe Gly  Lys Gln Ile Leu His  Val Ser Thr 
    1760                 1765                 1770             


Val Gln  Met Trp Leu Leu Leu  Lys Phe Asn Gln Thr  Glu Glu Val 
    1775                 1780                 1785             


Ser Val  Glu Thr Leu Leu Lys  Asp Ser Asp Leu Ser  Pro Glu Leu 
    1790                 1795                 1800             


Leu Leu  Gln Ala Leu Val Pro  Leu Thr Ser Gly Asn  Gly Pro Leu 
    1805                 1810                 1815             


Thr Leu  His Glu Gly Gln Asp  Phe Pro His Gly Gly  Val Leu Arg 
    1820                 1825                 1830             


Leu His  Glu Pro Gly Pro Gln  Arg Ser Gly Glu Ala  Leu Trp Leu 
    1835                 1840                 1845             


Ile Pro  Pro Gln Ala Tyr Leu  Asn Val Glu Lys Asp  Glu Gly Arg 
    1850                 1855                 1860             


Thr Leu  Glu Gln Lys Arg Asn  Leu Leu Ser Cys Leu  Leu Val Arg 
    1865                 1870                 1875             


Ile Leu  Lys Ala His Gly Glu  Lys Gly Leu His Ile  Asp Gln Leu 
    1880                 1885                 1890             


Val Cys  Leu Val Leu Glu Ala  Trp Gln Lys Gly Pro  Asn Pro Pro 
    1895                 1900                 1905             


Gly Thr  Leu Gly His Thr Val  Ala Gly Gly Val Ala  Cys Thr Ser 
    1910                 1915                 1920             


Thr Asp  Val Leu Ser Cys Ile  Leu His Leu Leu Gly  Gln Gly Tyr 
    1925                 1930                 1935             


Val Lys  Arg Arg Asp Asp Arg  Pro Gln Ile Leu Met  Tyr Ala Ala 
    1940                 1945                 1950             


Pro Glu  Pro Met Gly Pro Cys  Arg Gly Gln Ala Asp  Val Pro Phe 
    1955                 1960                 1965             


Cys Gly  Ser Gln Ser Glu Thr  Ser Lys Pro Ser Pro  Glu Ala Val 
    1970                 1975                 1980             


Ala Thr  Leu Ala Ser Leu Gln  Leu Pro Ala Gly Arg  Thr Met Ser 
    1985                 1990                 1995             


Pro Gln  Glu Val Glu Gly Leu  Met Lys Gln Thr Val  Arg Gln Val 
    2000                 2005                 2010             


Gln Glu  Thr Leu Asn Leu Glu  Pro Asp Val Ala Gln  His Leu Leu 
    2015                 2020                 2025             


Ala His  Ser His Trp Gly Ala  Glu Gln Leu Leu Gln  Ser Tyr Ser 
    2030                 2035                 2040             


Glu Asp  Pro Glu Pro Leu Leu  Leu Ala Ala Gly Leu  Cys Val His 
    2045                 2050                 2055             


Gln Ala  Gln Ala Val Pro Val  Arg Pro Asp His Cys  Pro Val Cys 
    2060                 2065                 2070             


Val Ser  Pro Leu Gly Cys Asp  Asp Asp Leu Pro Ser  Leu Cys Cys 
    2075                 2080                 2085             


Met His  Tyr Cys Cys Lys Ser  Cys Trp Asn Glu Tyr  Leu Thr Thr 
    2090                 2095                 2100             


Arg Ile  Glu Gln Asn Leu Val  Leu Asn Cys Thr Cys  Pro Ile Ala 
    2105                 2110                 2115             


Asp Cys  Pro Ala Gln Pro Thr  Gly Ala Phe Ile Arg  Ala Ile Val 
    2120                 2125                 2130             


Ser Ser  Pro Glu Val Ile Ser  Lys Tyr Glu Lys Ala  Leu Leu Arg 
    2135                 2140                 2145             


Gly Tyr  Val Glu Ser Cys Ser  Asn Leu Thr Trp Cys  Thr Asn Pro 
    2150                 2155                 2160             


Gln Gly  Cys Asp Arg Ile Leu  Cys Arg Gln Gly Leu  Gly Cys Gly 
    2165                 2170                 2175             


Thr Thr  Cys Ser Lys Cys Gly  Trp Ala Ser Cys Phe  Asn Cys Ser 
    2180                 2185                 2190             


Phe Pro  Glu Ala His Tyr Pro  Ala Ser Cys Gly His  Met Ser Gln 
    2195                 2200                 2205             


Trp Val  Asp Asp Gly Gly Tyr  Tyr Asp Gly Met Ser  Val Glu Ala 
    2210                 2215                 2220             


Gln Ser  Lys His Leu Ala Lys  Leu Ile Ser Lys Arg  Cys Pro Ser 
    2225                 2230                 2235             


Cys Gln  Ala Pro Ile Glu Lys  Asn Glu Gly Cys Leu  His Met Thr 
    2240                 2245                 2250             


Cys Ala  Lys Cys Asn His Gly  Phe Cys Trp Arg Cys  Leu Lys Ser 
    2255                 2260                 2265             


Trp Lys  Pro Asn His Lys Asp  Tyr Tyr Asn Cys Ser  Ala Met Val 
    2270                 2275                 2280             


Ser Lys  Ala Ala Arg Gln Glu  Lys Arg Phe Gln Asp  Tyr Asn Glu 
    2285                 2290                 2295             


Arg Cys  Thr Phe His His Gln  Ala Arg Glu Phe Ala  Val Asn Leu 
    2300                 2305                 2310             


Arg Asn  Arg Val Ser Ala Ile  His Glu Val Pro Pro  Pro Arg Ser 
    2315                 2320                 2325             


Phe Thr  Phe Leu Asn Asp Ala  Cys Gln Gly Leu Glu  Gln Ala Arg 
    2330                 2335                 2340             


Lys Val  Leu Ala Tyr Ala Cys  Val Tyr Ser Phe Tyr  Ser Gln Asp 
    2345                 2350                 2355             


Ala Glu  Tyr Met Asp Val Val  Glu Gln Gln Thr Glu  Asn Leu Glu 
    2360                 2365                 2370             


Leu His  Thr Asn Ala Leu Gln  Ile Leu Leu Glu Glu  Thr Leu Leu 
    2375                 2380                 2385             


Arg Cys  Arg Asp Leu Ala Ser  Ser Leu Arg Leu Leu  Arg Ala Asp 
    2390                 2395                 2400             


Cys Leu  Ser Thr Gly Met Glu  Leu Leu Arg Arg Ile  Gln Glu Arg 
    2405                 2410                 2415             


Leu Leu  Ala Ile Leu Gln His  Ser Ala Gln Asp Phe  Arg Val Gly 
    2420                 2425                 2430             


Leu Gln  Ser Pro Ser Val Glu  Ala Trp Glu Ala Lys  Gly Pro Asn 
    2435                 2440                 2445             


Met Pro  Gly Ser Gln Pro Gln  Ala Ser Ser Gly Pro  Glu Ala Glu 
    2450                 2455                 2460             


Glu Glu  Glu Glu Asp Asp Glu  Asp Asp Val Pro Glu  Trp Gln Gln 
    2465                 2470                 2475             


Asp Glu  Phe Asp Glu Glu Leu  Asp Asn Asp Ser Phe  Ser Tyr Asp 
    2480                 2485                 2490             


Glu Ser  Glu Asn Leu Asp Gln  Glu Thr Phe Phe Phe  Gly Asp Glu 
    2495                 2500                 2505             


Glu Glu  Asp Glu Asp Glu Ala  Tyr Asp 
    2510                 2515         


<210>  2743
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUTA__Homo_sapiens__NP_001014433

<400>  2743

Met Ile Gly Ser Gly Leu Ala Gly Ser Gly Gly Ala Gly Gly Pro Ser 
1               5                   10                  15      


Ser Thr Val Thr Trp Cys Ala Leu Phe Ser Asn His Val Ala Ala Thr 
            20                  25                  30          


Gln Ala Ser Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro 
        35                  40                  45              


Val Ala Ser Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala 
    50                  55                  60                  


Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser 
65                  70                  75                  80  


Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn 
                85                  90                  95      


Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu 
            100                 105                 110         


Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp 
        115                 120                 125             


Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr 
    130                 135                 140                 


Gln Ser Ser Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn 
                165                 170                 175     


Phe Pro Tyr Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp 
            180                 185                 190         


Ser Ile Thr Val Leu Pro 
        195             


<210>  2744
<211>  1516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUX1__Homo_sapiens__NP_001189472

<400>  2744

Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Gln Gln Leu Gln Arg Glu Leu Asp Ala Thr Ala Thr Val Leu Ala 
            20                  25                  30          


Asn Arg Gln Asp Glu Ser Glu Gln Ser Arg Lys Arg Leu Ile Glu Gln 
        35                  40                  45              


Ser Arg Glu Phe Lys Lys Asn Thr Pro Glu Asp Leu Arg Lys Gln Val 
    50                  55                  60                  


Ala Pro Leu Leu Lys Ser Phe Gln Gly Glu Ile Asp Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Lys Glu Ala Glu Ala Ala Phe Leu Asn Val Tyr Lys Arg Leu 
                85                  90                  95      


Ile Asp Val Pro Asp Pro Val Pro Ala Leu Asp Leu Gly Gln Gln Leu 
            100                 105                 110         


Gln Leu Lys Val Gln Arg Leu His Asp Ile Glu Thr Glu Asn Gln Lys 
        115                 120                 125             


Leu Arg Glu Thr Leu Glu Glu Tyr Asn Lys Glu Phe Ala Glu Val Lys 
    130                 135                 140                 


Asn Gln Glu Val Thr Ile Lys Ala Leu Lys Glu Lys Ile Arg Glu Tyr 
145                 150                 155                 160 


Glu Gln Thr Leu Lys Asn Gln Ala Glu Thr Ile Ala Leu Glu Lys Glu 
                165                 170                 175     


Gln Lys Leu Gln Asn Asp Phe Ala Glu Lys Glu Arg Lys Leu Gln Glu 
            180                 185                 190         


Thr Gln Met Ser Thr Thr Ser Lys Leu Glu Glu Ala Glu His Lys Val 
        195                 200                 205             


Gln Ser Leu Gln Thr Ala Leu Glu Lys Thr Arg Thr Glu Leu Phe Asp 
    210                 215                 220                 


Leu Lys Thr Lys Tyr Asp Glu Glu Thr Thr Ala Lys Ala Asp Glu Ile 
225                 230                 235                 240 


Glu Met Ile Met Thr Asp Leu Glu Arg Ala Asn Gln Arg Ala Glu Val 
                245                 250                 255     


Ala Gln Arg Glu Ala Glu Thr Leu Arg Glu Gln Leu Ser Ser Ala Asn 
            260                 265                 270         


His Ser Leu Gln Leu Ala Ser Gln Ile Gln Lys Ala Pro Asp Val Glu 
        275                 280                 285             


Gln Ala Ile Glu Val Leu Thr Arg Ser Ser Leu Glu Val Glu Leu Ala 
    290                 295                 300                 


Ala Lys Glu Arg Glu Ile Ala Gln Leu Val Glu Asp Val Gln Arg Leu 
305                 310                 315                 320 


Gln Ala Ser Leu Thr Lys Leu Arg Glu Asn Ser Ala Ser Gln Ile Ser 
                325                 330                 335     


Gln Leu Glu Gln Gln Leu Ser Ala Lys Asn Ser Thr Leu Lys Gln Leu 
            340                 345                 350         


Glu Glu Lys Leu Lys Gly Gln Ala Asp Tyr Glu Glu Val Lys Lys Glu 
        355                 360                 365             


Leu Asn Ile Leu Lys Ser Met Glu Phe Ala Pro Ser Glu Gly Ala Gly 
    370                 375                 380                 


Thr Gln Asp Ala Ala Lys Pro Leu Glu Val Leu Leu Leu Glu Lys Asn 
385                 390                 395                 400 


Arg Ser Leu Gln Ser Glu Asn Ala Ala Leu Arg Ile Ser Asn Ser Asp 
                405                 410                 415     


Leu Ser Gly Ser Ala Arg Arg Lys Gly Lys Asp Gln Pro Glu Ser Arg 
            420                 425                 430         


Arg Pro Gly Ser Leu Pro Ala Pro Pro Pro Ser Gln Leu Pro Arg Asn 
        435                 440                 445             


Pro Gly Glu Gln Ala Ser Asn Thr Asn Gly Thr His Gln Phe Ser Pro 
    450                 455                 460                 


Ala Gly Leu Ser Gln Asp Phe Phe Ser Ser Ser Leu Ala Ser Pro Ser 
465                 470                 475                 480 


Leu Pro Leu Ala Ser Thr Gly Lys Phe Ala Leu Asn Ser Leu Leu Gln 
                485                 490                 495     


Arg Gln Leu Met Gln Ser Phe Tyr Ser Lys Ala Met Gln Glu Ala Gly 
            500                 505                 510         


Ser Thr Ser Met Ile Phe Ser Thr Gly Pro Tyr Ser Thr Asn Ser Ile 
        515                 520                 525             


Ser Ser Gln Ser Pro Leu Gln Gln Ser Pro Asp Val Asn Gly Met Ala 
    530                 535                 540                 


Pro Ser Pro Ser Gln Ser Glu Ser Ala Gly Ser Val Ser Glu Gly Glu 
545                 550                 555                 560 


Glu Met Asp Thr Ala Glu Ile Ala Arg Gln Val Lys Glu Gln Leu Ile 
                565                 570                 575     


Lys His Asn Ile Gly Gln Arg Ile Phe Gly His Tyr Val Leu Gly Leu 
            580                 585                 590         


Ser Gln Gly Ser Val Ser Glu Ile Leu Ala Arg Pro Lys Pro Trp Asn 
        595                 600                 605             


Lys Leu Thr Val Arg Gly Lys Glu Pro Phe His Lys Met Lys Gln Phe 
    610                 615                 620                 


Leu Ser Asp Glu Gln Asn Ile Leu Ala Leu Arg Ser Ile Gln Gly Arg 
625                 630                 635                 640 


Gln Arg Glu Asn Pro Gly Gln Ser Leu Asn Arg Leu Phe Gln Glu Val 
                645                 650                 655     


Pro Lys Arg Arg Asn Gly Ser Glu Gly Asn Ile Thr Thr Arg Ile Arg 
            660                 665                 670         


Ala Ser Glu Thr Gly Ser Asp Glu Ala Ile Lys Ser Ile Leu Glu Gln 
        675                 680                 685             


Ala Lys Arg Glu Leu Gln Val Gln Lys Thr Ala Glu Pro Ala Gln Pro 
    690                 695                 700                 


Ser Ser Ala Ser Gly Ser Gly Asn Ser Asp Asp Ala Ile Arg Ser Ile 
705                 710                 715                 720 


Leu Gln Gln Ala Arg Arg Glu Met Glu Ala Gln Gln Ala Ala Leu Asp 
                725                 730                 735     


Pro Ala Leu Lys Gln Ala Pro Leu Ser Gln Ser Asp Ile Thr Ile Leu 
            740                 745                 750         


Thr Pro Lys Leu Leu Ser Thr Ser Pro Met Pro Thr Val Ser Ser Tyr 
        755                 760                 765             


Pro Pro Leu Ala Ile Ser Leu Lys Lys Pro Ser Ala Ala Pro Glu Ala 
    770                 775                 780                 


Gly Ala Ser Ala Leu Pro Asn Pro Pro Ala Leu Lys Lys Glu Ala Gln 
785                 790                 795                 800 


Asp Ala Pro Gly Leu Asp Pro Gln Gly Ala Ala Asp Cys Ala Gln Gly 
                805                 810                 815     


Val Leu Arg Gln Val Lys Asn Glu Val Gly Arg Ser Gly Ala Trp Lys 
            820                 825                 830         


Asp His Trp Trp Ser Ala Val Gln Pro Glu Arg Arg Asn Ala Ala Ser 
        835                 840                 845             


Ser Glu Glu Ala Lys Ala Glu Glu Thr Gly Gly Gly Lys Glu Lys Gly 
    850                 855                 860                 


Ser Gly Gly Ser Gly Gly Gly Ser Gln Pro Arg Ala Glu Arg Ser Gln 
865                 870                 875                 880 


Leu Gln Gly Pro Ser Ser Ser Glu Tyr Trp Lys Glu Trp Pro Ser Ala 
                885                 890                 895     


Glu Ser Pro Tyr Ser Gln Ser Ser Glu Leu Ser Leu Thr Gly Ala Ser 
            900                 905                 910         


Arg Ser Glu Thr Pro Gln Asn Ser Pro Leu Pro Ser Ser Pro Ile Val 
        915                 920                 925             


Pro Met Ser Lys Pro Thr Lys Pro Ser Val Pro Pro Leu Thr Pro Glu 
    930                 935                 940                 


Gln Tyr Glu Val Tyr Met Tyr Gln Glu Val Asp Thr Ile Glu Leu Thr 
945                 950                 955                 960 


Arg Gln Val Lys Glu Lys Leu Ala Lys Asn Gly Ile Cys Gln Arg Ile 
                965                 970                 975     


Phe Gly Glu Lys Val Leu Gly Leu Ser Gln Gly Ser Val Ser Asp Met 
            980                 985                 990         


Leu Ser Arg Pro Lys Pro Trp Ser  Lys Leu Thr Gln Lys  Gly Arg Glu 
        995                 1000                 1005             


Pro Phe  Ile Arg Met Gln Leu  Trp Leu Asn Gly Glu  Leu Gly Gln 
    1010                 1015                 1020             


Gly Val  Leu Pro Val Gln Gly  Gln Gln Gln Gly Pro  Val Leu His 
    1025                 1030                 1035             


Ser Val  Thr Ser Leu Gln Asp  Pro Leu Gln Gln Gly  Cys Val Ser 
    1040                 1045                 1050             


Ser Glu  Ser Thr Pro Lys Thr  Ser Ala Ser Cys Ser  Pro Ala Pro 
    1055                 1060                 1065             


Glu Ser  Pro Met Ser Ser Ser  Glu Ser Val Lys Ser  Leu Thr Glu 
    1070                 1075                 1080             


Leu Val  Gln Gln Pro Cys Pro  Pro Ile Glu Ala Ser  Lys Asp Ser 
    1085                 1090                 1095             


Lys Pro  Pro Glu Pro Ser Asp  Pro Pro Ala Ser Asp  Ser Gln Pro 
    1100                 1105                 1110             


Thr Thr  Pro Leu Pro Leu Ser  Gly His Ser Ala Leu  Ser Ile Gln 
    1115                 1120                 1125             


Glu Leu  Val Ala Met Ser Pro  Glu Leu Asp Thr Tyr  Gly Ile Thr 
    1130                 1135                 1140             


Lys Arg  Val Lys Glu Val Leu  Thr Asp Asn Asn Leu  Gly Gln Arg 
    1145                 1150                 1155             


Leu Phe  Gly Glu Thr Ile Leu  Gly Leu Thr Gln Gly  Ser Val Ser 
    1160                 1165                 1170             


Asp Leu  Leu Ala Arg Pro Lys  Pro Trp His Lys Leu  Ser Leu Lys 
    1175                 1180                 1185             


Gly Arg  Glu Pro Phe Val Arg  Met Gln Leu Trp Leu  Asn Asp Pro 
    1190                 1195                 1200             


Asn Asn  Val Glu Lys Leu Met  Asp Met Lys Arg Met  Glu Lys Lys 
    1205                 1210                 1215             


Ala Tyr  Met Lys Arg Arg His  Ser Ser Val Ser Asp  Ser Gln Pro 
    1220                 1225                 1230             


Cys Glu  Pro Pro Ser Val Gly  Thr Glu Tyr Ser Gln  Gly Ala Ser 
    1235                 1240                 1245             


Pro Gln  Pro Gln His Gln Leu  Lys Lys Pro Arg Val  Val Leu Ala 
    1250                 1255                 1260             


Pro Glu  Glu Lys Glu Ala Leu  Lys Arg Ala Tyr Gln  Gln Lys Pro 
    1265                 1270                 1275             


Tyr Pro  Ser Pro Lys Thr Ile  Glu Asp Leu Ala Thr  Gln Leu Asn 
    1280                 1285                 1290             


Leu Lys  Thr Ser Thr Val Ile  Asn Trp Phe His Asn  Tyr Arg Ser 
    1295                 1300                 1305             


Arg Ile  Arg Arg Glu Leu Phe  Ile Glu Glu Ile Gln  Ala Gly Ser 
    1310                 1315                 1320             


Gln Gly  Gln Ala Gly Ala Ser  Asp Ser Pro Ser Ala  Arg Ser Gly 
    1325                 1330                 1335             


Arg Ala  Ala Pro Ser Ser Glu  Gly Asp Ser Cys Asp  Gly Val Glu 
    1340                 1345                 1350             


Ala Thr  Glu Gly Pro Gly Ser  Ala Asp Thr Glu Glu  Pro Lys Ser 
    1355                 1360                 1365             


Gln Gly  Glu Ala Glu Arg Glu  Glu Val Pro Arg Pro  Ala Glu Gln 
    1370                 1375                 1380             


Thr Glu  Pro Pro Pro Ser Gly  Thr Pro Gly Pro Asp  Asp Ala Arg 
    1385                 1390                 1395             


Asp Asp  Asp His Glu Gly Gly  Pro Val Glu Gly Pro  Gly Pro Leu 
    1400                 1405                 1410             


Pro Ser  Pro Ala Ser Ala Thr  Ala Thr Ala Ala Pro  Ala Ala Pro 
    1415                 1420                 1425             


Glu Asp  Ala Ala Thr Ser Ala  Ala Ala Ala Pro Gly  Glu Gly Pro 
    1430                 1435                 1440             


Ala Ala  Pro Ser Ser Ala Pro  Pro Pro Ser Asn Ser  Ser Ser Ser 
    1445                 1450                 1455             


Ser Ala  Pro Arg Arg Pro Ser  Ser Leu Gln Ser Leu  Phe Gly Leu 
    1460                 1465                 1470             


Pro Glu  Ala Ala Gly Ala Arg  Asp Ser Arg Asp Asn  Pro Leu Arg 
    1475                 1480                 1485             


Lys Lys  Lys Ala Ala Asn Leu  Asn Ser Ile Ile His  Arg Leu Glu 
    1490                 1495                 1500             


Lys Ala  Ala Ser Arg Glu Glu  Pro Ile Glu Trp Glu  Phe 
    1505                 1510                 1515     


<210>  2745
<211>  1486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUX2__Homo_sapiens__NP_056082

<400>  2745

Met Ala Ala Asn Val Gly Ser Met Phe Gln Tyr Trp Lys Arg Phe Asp 
1               5                   10                  15      


Leu Arg Arg Leu Gln Lys Glu Leu Asn Ser Val Ala Ser Glu Leu Ser 
            20                  25                  30          


Ala Arg Gln Glu Glu Ser Glu His Ser His Lys His Leu Ile Glu Leu 
        35                  40                  45              


Arg Arg Glu Phe Lys Lys Asn Val Pro Glu Glu Ile Arg Glu Met Val 
    50                  55                  60                  


Ala Pro Val Leu Lys Ser Phe Gln Ala Glu Val Val Ala Leu Ser Lys 
65                  70                  75                  80  


Arg Ser Gln Glu Ala Glu Ala Ala Phe Leu Ser Val Tyr Lys Gln Leu 
                85                  90                  95      


Ile Glu Ala Pro Asp Pro Val Pro Val Phe Glu Ala Ala Arg Ser Leu 
            100                 105                 110         


Asp Asp Arg Leu Gln Pro Pro Ser Phe Asp Pro Ser Gly Gln Pro Arg 
        115                 120                 125             


Arg Asp Leu His Thr Ser Trp Lys Arg Asn Pro Glu Leu Leu Ser Pro 
    130                 135                 140                 


Lys Glu Gln Arg Glu Gly Thr Ser Pro Ala Gly Pro Thr Leu Thr Glu 
145                 150                 155                 160 


Gly Ser Arg Leu Pro Gly Ile Pro Gly Lys Ala Leu Leu Thr Glu Thr 
                165                 170                 175     


Leu Leu Gln Arg Asn Glu Ala Glu Lys Gln Lys Gly Leu Gln Glu Val 
            180                 185                 190         


Gln Ile Thr Leu Ala Ala Arg Leu Gly Glu Ala Glu Glu Lys Ile Lys 
        195                 200                 205             


Val Leu His Ser Ala Leu Lys Ala Thr Gln Ala Glu Leu Leu Glu Leu 
    210                 215                 220                 


Arg Arg Lys Tyr Asp Glu Glu Ala Ala Ser Lys Ala Asp Glu Val Gly 
225                 230                 235                 240 


Leu Ile Met Thr Asn Leu Glu Lys Ala Asn Gln Arg Ala Glu Ala Ala 
                245                 250                 255     


Gln Arg Glu Val Glu Ser Leu Arg Glu Gln Leu Ala Ser Val Asn Ser 
            260                 265                 270         


Ser Ile Arg Leu Ala Cys Cys Ser Pro Gln Gly Pro Ser Gly Asp Lys 
        275                 280                 285             


Val Asn Phe Thr Leu Cys Ser Gly Pro Arg Leu Glu Ala Ala Leu Ala 
    290                 295                 300                 


Ser Lys Asp Arg Glu Ile Leu Arg Leu Leu Lys Asp Val Gln His Leu 
305                 310                 315                 320 


Gln Ser Ser Leu Gln Glu Leu Glu Glu Ala Ser Ala Asn Gln Ile Ala 
                325                 330                 335     


Asp Leu Glu Arg Gln Leu Thr Ala Lys Ser Glu Ala Ile Glu Lys Leu 
            340                 345                 350         


Glu Glu Lys Leu Gln Ala Gln Ser Asp Tyr Glu Glu Ile Lys Thr Glu 
        355                 360                 365             


Leu Ser Ile Leu Lys Ala Met Lys Leu Ala Ser Ser Thr Cys Ser Leu 
    370                 375                 380                 


Pro Gln Gly Met Ala Lys Pro Glu Asp Ser Leu Leu Ile Ala Lys Glu 
385                 390                 395                 400 


Ala Phe Phe Pro Thr Gln Lys Phe Leu Leu Glu Lys Pro Ser Leu Leu 
                405                 410                 415     


Ala Ser Pro Glu Glu Asp Pro Ser Glu Asp Asp Ser Ile Lys Asp Ser 
            420                 425                 430         


Leu Gly Thr Glu Gln Ser Tyr Pro Ser Pro Gln Gln Leu Pro Pro Pro 
        435                 440                 445             


Pro Gly Pro Glu Asp Pro Leu Ser Pro Ser Pro Gly Gln Pro Leu Leu 
    450                 455                 460                 


Gly Pro Ser Leu Gly Pro Asp Gly Thr Arg Thr Phe Ser Leu Ser Pro 
465                 470                 475                 480 


Phe Pro Ser Leu Ala Ser Gly Glu Arg Leu Met Met Pro Pro Ala Ala 
                485                 490                 495     


Phe Lys Gly Glu Ala Gly Gly Leu Leu Val Phe Pro Pro Ala Phe Tyr 
            500                 505                 510         


Gly Ala Lys Pro Pro Thr Ala Pro Ala Thr Pro Ala Pro Gly Pro Glu 
        515                 520                 525             


Pro Leu Gly Gly Pro Glu Pro Ala Asp Gly Gly Gly Gly Gly Ala Ala 
    530                 535                 540                 


Gly Pro Gly Ala Glu Glu Glu Gln Leu Asp Thr Ala Glu Ile Ala Phe 
545                 550                 555                 560 


Gln Val Lys Glu Gln Leu Leu Lys His Asn Ile Gly Gln Arg Val Phe 
                565                 570                 575     


Gly His Tyr Val Leu Gly Leu Ser Gln Gly Ser Val Ser Glu Ile Leu 
            580                 585                 590         


Ala Arg Pro Lys Pro Trp Arg Lys Leu Thr Val Lys Gly Lys Glu Pro 
        595                 600                 605             


Phe Ile Lys Met Lys Gln Phe Leu Ser Asp Glu Gln Asn Val Leu Ala 
    610                 615                 620                 


Leu Arg Thr Ile Gln Val Arg Gln Arg Gly Ser Ile Thr Pro Arg Ile 
625                 630                 635                 640 


Arg Thr Pro Glu Thr Gly Ser Asp Asp Ala Ile Lys Ser Ile Leu Glu 
                645                 650                 655     


Gln Ala Lys Lys Glu Ile Glu Ser Gln Lys Gly Gly Glu Pro Lys Thr 
            660                 665                 670         


Ser Val Ala Pro Leu Ser Ile Ala Asn Gly Thr Thr Pro Ala Ser Thr 
        675                 680                 685             


Ser Glu Asp Ala Ile Lys Ser Ile Leu Glu Gln Ala Arg Arg Glu Met 
    690                 695                 700                 


Gln Ala Gln Gln Gln Ala Leu Leu Glu Met Glu Val Ala Pro Arg Gly 
705                 710                 715                 720 


Arg Ser Val Pro Pro Ser Pro Pro Glu Arg Pro Ser Leu Ala Thr Ala 
                725                 730                 735     


Ser Gln Asn Gly Ala Pro Ala Leu Val Lys Gln Glu Glu Gly Ser Gly 
            740                 745                 750         


Gly Pro Ala Gln Ala Pro Leu Pro Val Leu Ser Pro Ala Ala Phe Val 
        755                 760                 765             


Gln Ser Ile Ile Arg Lys Val Lys Ser Glu Ile Gly Asp Ala Gly Tyr 
    770                 775                 780                 


Phe Asp His His Trp Ala Ser Asp Arg Gly Leu Leu Ser Arg Pro Tyr 
785                 790                 795                 800 


Ala Ser Val Ser Pro Ser Leu Ser Ser Ser Ser Ser Ser Gly Tyr Ser 
                805                 810                 815     


Gly Gln Pro Asn Gly Arg Ala Trp Pro Arg Gly Asp Glu Ala Pro Val 
            820                 825                 830         


Pro Pro Glu Asp Glu Ala Ala Ala Gly Ala Glu Asp Glu Pro Pro Arg 
        835                 840                 845             


Thr Gly Glu Leu Lys Ala Glu Gly Ala Thr Ala Glu Ala Gly Ala Arg 
    850                 855                 860                 


Leu Pro Tyr Tyr Pro Ala Tyr Val Pro Arg Thr Leu Lys Pro Thr Val 
865                 870                 875                 880 


Pro Pro Leu Thr Pro Glu Gln Tyr Glu Leu Tyr Met Tyr Arg Glu Val 
                885                 890                 895     


Asp Thr Leu Glu Leu Thr Arg Gln Val Lys Glu Lys Leu Ala Lys Asn 
            900                 905                 910         


Gly Ile Cys Gln Arg Ile Phe Gly Glu Lys Val Leu Gly Leu Ser Gln 
        915                 920                 925             


Gly Ser Val Ser Asp Met Leu Ser Arg Pro Lys Pro Trp Ser Lys Leu 
    930                 935                 940                 


Thr Gln Lys Gly Arg Glu Pro Phe Ile Arg Met Gln Leu Trp Leu Ser 
945                 950                 955                 960 


Asp Gln Leu Gly Gln Ala Val Gly Gln Gln Pro Gly Ala Ser Gln Ala 
                965                 970                 975     


Ser Pro Thr Glu Pro Arg Ser Ser Pro Ser Pro Pro Pro Ser Pro Thr 
            980                 985                 990         


Glu Pro Glu Lys Ser Ser Gln Glu  Pro Leu Ser Leu Ser  Leu Glu Ser 
        995                 1000                 1005             


Ser Lys  Glu Asn Gln Gln Pro  Glu Gly Arg Ser Ser  Ser Ser Leu 
    1010                 1015                 1020             


Ser Gly  Lys Met Tyr Ser Gly  Ser Gln Ala Pro Gly  Gly Ile Gln 
    1025                 1030                 1035             


Glu Ile  Val Ala Met Ser Pro  Glu Leu Asp Thr Tyr  Ser Ile Thr 
    1040                 1045                 1050             


Lys Arg  Val Lys Glu Val Leu  Thr Asp Asn Asn Leu  Gly Gln Arg 
    1055                 1060                 1065             


Leu Phe  Gly Glu Ser Ile Leu  Gly Leu Thr Gln Gly  Ser Val Ser 
    1070                 1075                 1080             


Asp Leu  Leu Ser Arg Pro Lys  Pro Trp His Lys Leu  Ser Leu Lys 
    1085                 1090                 1095             


Gly Arg  Glu Pro Phe Val Arg  Met Gln Leu Trp Leu  Asn Asp Pro 
    1100                 1105                 1110             


His Asn  Val Glu Lys Leu Arg  Asp Met Lys Lys Leu  Glu Lys Lys 
    1115                 1120                 1125             


Ala Tyr  Leu Lys Arg Arg Tyr  Gly Leu Ile Ser Thr  Gly Ser Asp 
    1130                 1135                 1140             


Ser Glu  Ser Pro Ala Thr Arg  Ser Glu Cys Pro Ser  Pro Cys Leu 
    1145                 1150                 1155             


Gln Pro  Gln Asp Leu Ser Leu  Leu Gln Ile Lys Lys  Pro Arg Val 
    1160                 1165                 1170             


Val Leu  Ala Pro Glu Glu Lys  Glu Ala Leu Arg Lys  Ala Tyr Gln 
    1175                 1180                 1185             


Leu Glu  Pro Tyr Pro Ser Gln  Gln Thr Ile Glu Leu  Leu Ser Phe 
    1190                 1195                 1200             


Gln Leu  Asn Leu Lys Thr Asn  Thr Val Ile Asn Trp  Phe His Asn 
    1205                 1210                 1215             


Tyr Arg  Ser Arg Met Arg Arg  Glu Met Leu Val Glu  Gly Thr Gln 
    1220                 1225                 1230             


Asp Glu  Pro Asp Leu Asp Pro  Ser Gly Gly Pro Gly  Ile Leu Pro 
    1235                 1240                 1245             


Pro Gly  His Ser His Pro Asp  Pro Thr Pro Gln Ser  Pro Asp Ser 
    1250                 1255                 1260             


Glu Thr  Glu Asp Gln Lys Pro  Thr Val Lys Glu Leu  Glu Leu Gln 
    1265                 1270                 1275             


Glu Gly  Pro Glu Glu Asn Ser  Thr Pro Leu Thr Thr  Gln Asp Lys 
    1280                 1285                 1290             


Ala Gln  Val Arg Ile Lys Gln  Glu Gln Met Glu Glu  Asp Ala Glu 
    1295                 1300                 1305             


Glu Glu  Ala Gly Ser Gln Pro  Gln Asp Ser Gly Glu  Leu Asp Lys 
    1310                 1315                 1320             


Gly Gln  Gly Pro Pro Lys Glu  Glu His Pro Asp Pro  Pro Gly Asn 
    1325                 1330                 1335             


Asp Gly  Leu Pro Lys Val Ala  Pro Gly Pro Leu Leu  Pro Gly Gly 
    1340                 1345                 1350             


Ser Thr  Pro Asp Cys Pro Ser  Leu His Pro Gln Gln  Glu Ser Glu 
    1355                 1360                 1365             


Ala Gly  Glu Arg Leu His Pro  Asp Pro Leu Ser Phe  Lys Ser Ala 
    1370                 1375                 1380             


Ser Glu  Ser Ser Arg Cys Ser  Leu Glu Val Ser Leu  Asn Ser Pro 
    1385                 1390                 1395             


Ser Ala  Ala Ser Ser Pro Gly  Leu Met Met Ser Val  Ser Pro Val 
    1400                 1405                 1410             


Pro Ser  Ser Ser Ala Pro Ile  Ser Pro Ser Pro Pro  Gly Ala Pro 
    1415                 1420                 1425             


Pro Ala  Lys Val Pro Ser Ala  Ser Pro Thr Ala Asp  Met Ala Gly 
    1430                 1435                 1440             


Ala Leu  His Pro Ser Ala Lys  Val Asn Pro Asn Leu  Gln Arg Arg 
    1445                 1450                 1455             


His Glu  Lys Met Ala Asn Leu  Asn Asn Ile Ile Tyr  Arg Val Glu 
    1460                 1465                 1470             


Arg Ala  Ala Asn Arg Glu Glu  Ala Leu Glu Trp Glu  Phe 
    1475                 1480                 1485     


<210>  2746
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CUZD1__Homo_sapiens__NP_071317

<400>  2746

Met Glu Leu Val Arg Arg Leu Met Pro Leu Thr Leu Leu Ile Leu Ser 
1               5                   10                  15      


Cys Leu Ala Glu Leu Thr Met Ala Glu Ala Glu Gly Asn Ala Ser Cys 
            20                  25                  30          


Thr Val Ser Leu Gly Gly Ala Asn Met Ala Glu Thr His Lys Ala Met 
        35                  40                  45              


Ile Leu Gln Leu Asn Pro Ser Glu Asn Cys Thr Trp Thr Ile Glu Arg 
    50                  55                  60                  


Pro Glu Asn Lys Ser Ile Arg Ile Ile Phe Ser Tyr Val Gln Leu Asp 
65                  70                  75                  80  


Pro Asp Gly Ser Cys Glu Ser Glu Asn Ile Lys Val Phe Asp Gly Thr 
                85                  90                  95      


Ser Ser Asn Gly Pro Leu Leu Gly Gln Val Cys Ser Lys Asn Asp Tyr 
            100                 105                 110         


Val Pro Val Phe Glu Ser Ser Ser Ser Thr Leu Thr Phe Gln Ile Val 
        115                 120                 125             


Thr Asp Ser Ala Arg Ile Gln Arg Thr Val Phe Val Phe Tyr Tyr Phe 
    130                 135                 140                 


Phe Ser Pro Asn Ile Ser Ile Pro Asn Cys Gly Gly Tyr Leu Asp Thr 
145                 150                 155                 160 


Leu Glu Gly Ser Phe Thr Ser Pro Asn Tyr Pro Lys Pro His Pro Glu 
                165                 170                 175     


Leu Ala Tyr Cys Val Trp His Ile Gln Val Glu Lys Asp Tyr Lys Ile 
            180                 185                 190         


Lys Leu Asn Phe Lys Glu Ile Phe Leu Glu Ile Asp Lys Gln Cys Lys 
        195                 200                 205             


Phe Asp Phe Leu Ala Ile Tyr Asp Gly Pro Ser Thr Asn Ser Gly Leu 
    210                 215                 220                 


Ile Gly Gln Val Cys Gly Arg Val Thr Pro Thr Phe Glu Ser Ser Ser 
225                 230                 235                 240 


Asn Ser Leu Thr Val Val Leu Ser Thr Asp Tyr Ala Asn Ser Tyr Arg 
                245                 250                 255     


Gly Phe Ser Ala Ser Tyr Thr Ser Ile Tyr Ala Glu Asn Ile Asn Thr 
            260                 265                 270         


Thr Ser Leu Thr Cys Ser Ser Asp Arg Met Arg Val Ile Ile Ser Lys 
        275                 280                 285             


Ser Tyr Leu Glu Ala Phe Asn Ser Asn Gly Asn Asn Leu Gln Leu Lys 
    290                 295                 300                 


Asp Pro Thr Cys Arg Pro Lys Leu Ser Asn Val Val Glu Phe Ser Val 
305                 310                 315                 320 


Pro Leu Asn Gly Cys Gly Thr Ile Arg Lys Val Glu Asp Gln Ser Ile 
                325                 330                 335     


Thr Tyr Thr Asn Ile Ile Thr Phe Ser Ala Ser Ser Thr Ser Glu Val 
            340                 345                 350         


Ile Thr Arg Gln Lys Gln Leu Gln Ile Ile Val Lys Cys Glu Met Gly 
        355                 360                 365             


His Asn Ser Thr Val Glu Ile Ile Tyr Ile Thr Glu Asp Asp Val Ile 
    370                 375                 380                 


Gln Ser Gln Asn Ala Leu Gly Lys Tyr Asn Thr Ser Met Ala Leu Phe 
385                 390                 395                 400 


Glu Ser Asn Ser Phe Glu Lys Thr Ile Leu Glu Ser Pro Tyr Tyr Val 
                405                 410                 415     


Asp Leu Asn Gln Thr Leu Phe Val Gln Val Ser Leu His Thr Ser Asp 
            420                 425                 430         


Pro Asn Leu Val Val Phe Leu Asp Thr Cys Arg Ala Ser Pro Thr Ser 
        435                 440                 445             


Asp Phe Ala Ser Pro Thr Tyr Asp Leu Ile Lys Ser Gly Cys Ser Arg 
    450                 455                 460                 


Asp Glu Thr Cys Lys Val Tyr Pro Leu Phe Gly His Tyr Gly Arg Phe 
465                 470                 475                 480 


Gln Phe Asn Ala Phe Lys Phe Leu Arg Ser Met Ser Ser Val Tyr Leu 
                485                 490                 495     


Gln Cys Lys Val Leu Ile Cys Asp Ser Ser Asp His Gln Ser Arg Cys 
            500                 505                 510         


Asn Gln Gly Cys Val Ser Arg Ser Lys Arg Asp Ile Ser Ser Tyr Lys 
        515                 520                 525             


Trp Lys Thr Asp Ser Ile Ile Gly Pro Ile Arg Leu Lys Arg Asp Arg 
    530                 535                 540                 


Ser Ala Ser Gly Asn Ser Gly Phe Gln His Glu Thr His Ala Glu Glu 
545                 550                 555                 560 


Thr Pro Asn Gln Pro Phe Asn Ser Val His Leu Phe Ser Phe Met Val 
                565                 570                 575     


Leu Ala Leu Asn Val Val Thr Val Ala Thr Ile Thr Val Arg His Phe 
            580                 585                 590         


Val Asn Gln Arg Ala Asp Tyr Lys Tyr Gln Lys Leu Gln Asn Tyr 
        595                 600                 605         


<210>  2747
<211>  908
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CWC22__Homo_sapiens__NP_065994

<400>  2747

Met Lys Ser Ser Val Ala Gln Ile Lys Pro Ser Ser Gly His Asp Arg 
1               5                   10                  15      


Arg Glu Asn Leu Asn Ser Tyr Gln Arg Asn Ser Ser Pro Glu Asp Arg 
            20                  25                  30          


Tyr Glu Glu Gln Glu Arg Ser Pro Arg Asp Arg Asp Tyr Phe Asp Tyr 
        35                  40                  45              


Ser Arg Ser Asp Tyr Glu His Ser Arg Arg Gly Arg Ser Tyr Asp Ser 
    50                  55                  60                  


Ser Met Glu Ser Arg Asn Arg Asp Arg Glu Lys Arg Arg Glu Arg Glu 
65                  70                  75                  80  


Arg Asp Thr Asp Arg Lys Arg Ser Arg Lys Ser Pro Ser Pro Gly Arg 
                85                  90                  95      


Arg Asn Pro Glu Thr Ser Val Thr Gln Ser Ser Ser Ala Gln Asp Glu 
            100                 105                 110         


Pro Ala Thr Lys Lys Lys Lys Asp Glu Leu Asp Pro Leu Leu Thr Arg 
        115                 120                 125             


Thr Gly Gly Ala Tyr Ile Pro Pro Ala Lys Leu Arg Met Met Gln Glu 
    130                 135                 140                 


Gln Ile Thr Asp Lys Asn Ser Leu Ala Tyr Gln Arg Met Ser Trp Glu 
145                 150                 155                 160 


Ala Leu Lys Lys Ser Ile Asn Gly Leu Ile Asn Lys Val Asn Ile Ser 
                165                 170                 175     


Asn Ile Ser Ile Ile Ile Gln Glu Leu Leu Gln Glu Asn Ile Val Arg 
            180                 185                 190         


Gly Arg Gly Leu Leu Ser Arg Ser Val Leu Gln Ala Gln Ser Ala Ser 
        195                 200                 205             


Pro Ile Phe Thr His Val Tyr Ala Ala Leu Val Ala Ile Ile Asn Ser 
    210                 215                 220                 


Lys Phe Pro Gln Ile Gly Glu Leu Ile Leu Lys Arg Leu Ile Leu Asn 
225                 230                 235                 240 


Phe Arg Lys Gly Tyr Arg Arg Asn Asp Lys Gln Leu Cys Leu Thr Ala 
                245                 250                 255     


Ser Lys Phe Val Ala His Leu Ile Asn Gln Asn Val Ala His Glu Val 
            260                 265                 270         


Leu Cys Leu Glu Met Leu Thr Leu Leu Leu Glu Arg Pro Thr Asp Asp 
        275                 280                 285             


Ser Val Glu Val Ala Ile Gly Phe Leu Lys Glu Cys Gly Leu Lys Leu 
    290                 295                 300                 


Thr Gln Val Ser Pro Arg Gly Ile Asn Ala Ile Phe Glu Arg Leu Arg 
305                 310                 315                 320 


Asn Ile Leu His Glu Ser Glu Ile Asp Lys Arg Val Gln Tyr Met Ile 
                325                 330                 335     


Glu Val Met Phe Ala Val Arg Lys Asp Gly Phe Lys Asp His Pro Ile 
            340                 345                 350         


Ile Leu Glu Gly Leu Asp Leu Val Glu Glu Asp Asp Gln Phe Thr His 
        355                 360                 365             


Met Leu Pro Leu Glu Asp Asp Tyr Asn Pro Glu Asp Val Leu Asn Val 
    370                 375                 380                 


Phe Lys Met Asp Pro Asn Phe Met Glu Asn Glu Glu Lys Tyr Lys Ala 
385                 390                 395                 400 


Ile Lys Lys Glu Ile Leu Asp Glu Gly Asp Thr Asp Ser Asn Thr Asp 
                405                 410                 415     


Gln Asp Ala Gly Ser Ser Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Gly Glu Glu Asp Glu Glu Gly Gln Lys Val Thr Ile His Asp Lys Thr 
        435                 440                 445             


Glu Ile Asn Leu Val Ser Phe Arg Arg Thr Ile Tyr Leu Ala Ile Gln 
    450                 455                 460                 


Ser Ser Leu Asp Phe Glu Glu Cys Ala His Lys Leu Leu Lys Met Glu 
465                 470                 475                 480 


Phe Pro Glu Ser Gln Thr Lys Glu Leu Cys Asn Met Ile Leu Asp Cys 
                485                 490                 495     


Cys Ala Gln Gln Arg Thr Tyr Glu Lys Phe Phe Gly Leu Leu Ala Gly 
            500                 505                 510         


Arg Phe Cys Met Leu Lys Lys Glu Tyr Met Glu Ser Phe Glu Gly Ile 
        515                 520                 525             


Phe Lys Glu Gln Tyr Asp Thr Ile His Arg Leu Glu Thr Asn Lys Leu 
    530                 535                 540                 


Arg Asn Val Ala Lys Met Phe Ala His Leu Leu Tyr Thr Asp Ser Leu 
545                 550                 555                 560 


Pro Trp Ser Val Leu Glu Cys Ile Lys Leu Ser Glu Glu Thr Thr Thr 
                565                 570                 575     


Ser Ser Ser Arg Ile Phe Val Lys Ile Phe Phe Gln Glu Leu Cys Glu 
            580                 585                 590         


Tyr Met Gly Leu Pro Lys Leu Asn Ala Arg Leu Lys Asp Glu Thr Leu 
        595                 600                 605             


Gln Pro Phe Phe Glu Gly Leu Leu Pro Arg Asp Asn Pro Arg Asn Thr 
    610                 615                 620                 


Arg Phe Ala Ile Asn Phe Phe Thr Ser Ile Gly Leu Gly Gly Leu Thr 
625                 630                 635                 640 


Asp Glu Leu Arg Glu His Leu Lys Asn Thr Pro Lys Val Ile Val Ala 
                645                 650                 655     


Gln Lys Pro Asp Val Glu Gln Asn Lys Ser Ser Pro Ser Ser Ser Ser 
            660                 665                 670         


Ser Ala Ser Ser Ser Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Asp 
        675                 680                 685             


Ser Ser Asp Ser Ser Ser Glu Ser Ser Ser Glu Glu Ser Asp Ser Ser 
    690                 695                 700                 


Ser Ile Ser Ser His Ser Ser Ala Ser Ala Asn Asp Val Arg Lys Lys 
705                 710                 715                 720 


Gly His Gly Lys Thr Arg Ser Lys Glu Val Asp Lys Leu Ile Arg Asn 
                725                 730                 735     


Gln Gln Thr Asn Asp Arg Lys Gln Lys Glu Arg Arg Gln Glu His Gly 
            740                 745                 750         


His Gln Glu Thr Arg Thr Glu Arg Glu Arg Arg Ser Glu Lys His Arg 
        755                 760                 765             


Asp Gln Asn Ser Ser Gly Ser Asn Trp Arg Asp Pro Ile Thr Lys Tyr 
    770                 775                 780                 


Thr Ser Asp Lys Asp Val Pro Ser Glu Arg Asn Asn Tyr Ser Arg Val 
785                 790                 795                 800 


Ala Asn Asp Arg Asp Gln Glu Met His Ile Asp Leu Glu Asn Lys His 
                805                 810                 815     


Gly Asp Pro Lys Lys Lys Arg Gly Glu Arg Arg Asn Ser Phe Ser Glu 
            820                 825                 830         


Asn Glu Lys His Thr His Arg Ile Lys Asp Ser Glu Asn Phe Arg Arg 
        835                 840                 845             


Lys Asp Arg Ser Lys Ser Lys Glu Met Asn Arg Lys His Ser Gly Ser 
    850                 855                 860                 


Arg Ser Asp Glu Asp Arg Tyr Gln Asn Gly Ala Glu Arg Arg Trp Glu 
865                 870                 875                 880 


Lys Ser Ser Arg Tyr Ser Glu Gln Ser Arg Glu Ser Lys Lys Asn Gln 
                885                 890                 895     


Asp Arg Arg Arg Glu Lys Ser Pro Ala Lys Gln Lys 
            900                 905             


<210>  2748
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CWC27__Homo_sapiens__NP_001284573

<400>  2748

Met Ser Asn Ile Tyr Ile Gln Glu Pro Pro Thr Asn Gly Lys Val Leu 
1               5                   10                  15      


Leu Lys Thr Thr Ala Gly Asp Ile Asp Ile Glu Leu Trp Ser Lys Glu 
            20                  25                  30          


Ala Pro Lys Ala Cys Arg Asn Phe Ile Gln Leu Cys Leu Glu Ala Tyr 
        35                  40                  45              


Tyr Asp Asn Thr Ile Phe His Arg Val Val Pro Gly Phe Ile Val Gln 
    50                  55                  60                  


Gly Gly Asp Pro Thr Gly Thr Gly Ser Gly Gly Glu Ser Ile Tyr Gly 
65                  70                  75                  80  


Ala Pro Phe Lys Asp Glu Phe His Ser Arg Leu Arg Phe Asn Arg Arg 
                85                  90                  95      


Gly Leu Val Ala Met Ala Asn Ala Gly Ser His Asp Asn Gly Ser Gln 
            100                 105                 110         


Phe Phe Phe Thr Leu Gly Arg Ala Asp Glu Leu Asn Asn Lys His Thr 
        115                 120                 125             


Ile Phe Gly Lys Val Thr Gly Asp Thr Val Tyr Asn Met Leu Arg Leu 
    130                 135                 140                 


Ser Glu Val Asp Ile Asp Asp Asp Glu Arg Pro His Asn Pro His Lys 
145                 150                 155                 160 


Ile Lys Ser Cys Glu Val Leu Phe Asn Pro Phe Asp Asp Ile Ile Pro 
                165                 170                 175     


Arg Glu Ile Lys Arg Leu Lys Lys Glu Lys Pro Glu Glu Glu Val Lys 
            180                 185                 190         


Lys Leu Lys Pro Lys Gly Thr Lys Asn Phe Ser Leu Leu Ser Phe Gly 
        195                 200                 205             


Glu Glu Ala Glu Glu Glu Glu Glu Glu Val Asn Arg Val Ser Gln Ser 
    210                 215                 220                 


Met Lys Gly Lys Ser Lys Ser Ser His Asp Leu Leu Lys Asp Asp Pro 
225                 230                 235                 240 


His Leu Ser Ser Val Pro Val Val Glu Ser Glu Lys Gly Asp Ala Pro 
                245                 250                 255     


Asp Leu Val Asp Asp Gly Glu Asp Glu Ser Ala Glu His Asp Glu Tyr 
            260                 265                 270         


Ile Asp Gly Asp Glu Lys Asn Leu Met Arg Glu Arg Ile Ala Lys Lys 
        275                 280                 285             


Leu Lys Lys Asp Thr Ser Ala Asn Val Lys Ser Ala Gly Glu Gly Glu 
    290                 295                 300                 


Val Glu Lys Lys Ser Val Ser Arg Ser Glu Glu Leu Arg Lys Glu Ala 
305                 310                 315                 320 


Arg Gln Leu Lys Arg Glu Leu Leu Ala Ala Lys Gln Lys Lys Val Glu 
                325                 330                 335     


Asn Ala Ala Lys Gln Ala Glu Lys Arg Ser Glu Glu Glu Glu Ala Pro 
            340                 345                 350         


Pro Asp Gly Ala Val Ala Glu Tyr Arg Arg Glu Lys Gln Lys Tyr Glu 
        355                 360                 365             


Ala Leu Arg Lys Gln Gln Ser Lys Lys Gly Thr Ser Arg Glu Asp Gln 
    370                 375                 380                 


Asp Val Thr Cys Thr Ser Val 
385                 390     


<210>  2749
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CWF19L1__Homo_sapiens__NP_001290333

<400>  2749

Met Ala Gln Lys Pro Leu Arg Leu Leu Ala Cys Gly Asp Val Glu Gly 
1               5                   10                  15      


Lys Phe Asp Ile Leu Phe Asn Arg Val Gln Ala Ile Gln Lys Lys Ser 
            20                  25                  30          


Gly Asn Phe Asp Leu Leu Leu Cys Val Gly Asn Phe Phe Gly Ser Thr 
        35                  40                  45              


Gln Asp Ala Glu Trp Glu Glu Tyr Lys Thr Gly Ile Lys Lys Ala Pro 
    50                  55                  60                  


Ile Gln Thr Tyr Val Leu Gly Ala Asn Asn Gln Glu Thr Val Lys Tyr 
65                  70                  75                  80  


Phe Gln Asp Ala Asp Gly Cys Glu Leu Ala Glu Asn Ile Thr Tyr Leu 
                85                  90                  95      


Gly Arg Lys Gly Ile Phe Thr Gly Ser Ser Gly Leu Gln Ile Val Tyr 
            100                 105                 110         


Leu Ser Gly Thr Glu Ser Leu Asn Glu Pro Val Pro Gly Tyr Ser Phe 
        115                 120                 125             


Ser Pro Lys Asp Val Ser Ser Leu Arg Met Met Leu Cys Thr Thr Ser 
    130                 135                 140                 


Gln Phe Lys Gly Val Asp Ile Leu Leu Thr Ser Pro Trp Pro Lys Cys 
145                 150                 155                 160 


Val Gly Asn Phe Gly Asn Ser Ser Gly Glu Val Asp Thr Lys Lys Cys 
                165                 170                 175     


Gly Ser Ala Leu Val Ser Ser Leu Ala Thr Gly Leu Lys Pro Arg Tyr 
            180                 185                 190         


His Phe Ala Ala Leu Glu Lys Thr Tyr Tyr Glu Arg Leu Pro Tyr Arg 
        195                 200                 205             


Asn His Ile Ile Leu Gln Glu Asn Ala Gln His Ala Thr Arg Phe Ile 
    210                 215                 220                 


Ala Leu Ala Asn Val Gly Asn Pro Glu Lys Lys Lys Tyr Leu Tyr Ala 
225                 230                 235                 240 


Phe Ser Ile Val Pro Met Lys Leu Met Asp Ala Ala Glu Leu Val Lys 
                245                 250                 255     


Gln Pro Pro Asp Val Thr Glu Asn Pro Tyr Arg Lys Ser Gly Gln Glu 
            260                 265                 270         


Ala Ser Ile Gly Lys Gln Ile Leu Ala Pro Val Glu Glu Ser Ala Cys 
        275                 280                 285             


Gln Phe Phe Phe Asp Leu Asn Glu Lys Gln Gly Arg Lys Arg Ser Ser 
    290                 295                 300                 


Thr Gly Arg Asp Ser Lys Ser Ser Pro His Pro Lys Gln Pro Arg Lys 
305                 310                 315                 320 


Pro Pro Gln Pro Pro Gly Pro Cys Trp Phe Cys Leu Ala Ser Pro Glu 
                325                 330                 335     


Val Glu Lys His Leu Val Val Asn Ile Gly Thr His Cys Tyr Leu Ala 
            340                 345                 350         


Leu Ala Lys Gly Gly Leu Ser Asp Asp His Val Leu Ile Leu Pro Ile 
        355                 360                 365             


Gly His Tyr Gln Ser Val Val Glu Leu Ser Ala Glu Val Val Glu Glu 
    370                 375                 380                 


Val Glu Lys Tyr Lys Ala Thr Leu Arg Arg Phe Phe Lys Ser Arg Gly 
385                 390                 395                 400 


Lys Trp Cys Val Val Phe Glu Arg Asn Tyr Lys Ser His His Leu Gln 
                405                 410                 415     


Leu Gln Ile Ala Gln Pro Gly Ala Ala Tyr Phe Tyr Val Glu Leu Asp 
            420                 425                 430         


Thr Gly Glu Lys Leu Phe His Arg Ile Lys Lys Asn Phe Pro Leu Gln 
        435                 440                 445             


Phe Gly Arg Glu Val Leu Ala Ser Glu Ala Ile Leu Asn Val Pro Asp 
    450                 455                 460                 


Lys Ser Asp Trp Arg Gln Cys Gln Ile Ser Lys Glu Asp Glu Glu Thr 
465                 470                 475                 480 


Leu Ala Arg Arg Phe Arg Lys Asp Phe Glu Pro Tyr Asp Phe Thr Leu 
                485                 490                 495     


Asp Asp 
        


<210>  2750
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CWF19L2__Homo_sapiens__NP_689647

<400>  2750

Met Ala Thr Ser Met Ala Ala Ala Ser Gly Arg Phe Glu Ser Ala Lys 
1               5                   10                  15      


Ser Ile Glu Glu Arg Lys Glu Gln Thr Arg Asn Ala Arg Ala Glu Val 
            20                  25                  30          


Leu Arg Gln Ala Lys Ala Asn Phe Glu Lys Glu Glu Arg Arg Lys Glu 
        35                  40                  45              


Leu Lys Arg Leu Arg Gly Glu Asp Thr Trp Met Leu Pro Asp Val Asn 
    50                  55                  60                  


Glu Arg Ile Glu Gln Phe Ser Gln Glu His Ser Val Lys Lys Lys Lys 
65                  70                  75                  80  


Lys Lys Asp Lys His Ser Lys Lys Ala Lys Lys Glu Lys Lys Lys Lys 
                85                  90                  95      


Ser Lys Lys Gln Lys Tyr Glu Lys Asn Asn Glu Ser Ser Asp Ser Ser 
            100                 105                 110         


Ser Ser Ser Glu Asp Glu Trp Val Glu Ala Val Pro Ser Gln Thr Pro 
        115                 120                 125             


Asp Lys Glu Lys Ala Trp Lys Val Lys Asp Glu Lys Ser Gly Lys Asp 
    130                 135                 140                 


Asp Thr Gln Ile Ile Lys Arg Asp Glu Trp Met Thr Val Asp Phe Met 
145                 150                 155                 160 


Ser Val Lys Thr Val Ser Ser Ser Ser Leu Lys Ala Glu Lys Glu Thr 
                165                 170                 175     


Met Arg Lys Ile Glu Gln Glu Lys Asn Gln Ala Leu Glu Gln Ser Lys 
            180                 185                 190         


Leu Met Glu Arg Glu Leu Asn Pro Tyr Trp Lys Asp Gly Gly Thr Gly 
        195                 200                 205             


Leu Pro Pro Glu Asp Cys Ser Val Ser Ser Ile Thr Lys Val Ser Val 
    210                 215                 220                 


Val Glu Asp Gly Gly Leu Ser Trp Leu Arg Lys Ser Tyr Leu Arg Met 
225                 230                 235                 240 


Lys Glu Gln Ala Glu Lys Gln Ser Arg Asn Phe Glu Asp Ile Val Ala 
                245                 250                 255     


Glu Arg Tyr Gly Ser Met Glu Ile Phe Gln Ser Lys Leu Glu Asp Ala 
            260                 265                 270         


Glu Lys Ala Ala Ser Thr Lys Glu Asp Tyr Arg Arg Glu Arg Trp Arg 
        275                 280                 285             


Lys Pro Thr Tyr Ser Asp Lys Ala Gln Asn Cys Gln Glu Ser Arg Glu 
    290                 295                 300                 


Ser Asp Leu Val Lys Tyr Gly Asn Ser Ser Arg Asp Arg Tyr Ala Thr 
305                 310                 315                 320 


Thr Asp Thr Ala Lys Asn Ser Asn Asn Glu Lys Phe Ile Gly Asp Glu 
                325                 330                 335     


Lys Asp Lys Arg Pro Gly Ser Leu Glu Thr Cys Arg Arg Glu Ser Asn 
            340                 345                 350         


Pro Arg Gln Asn Gln Glu Phe Ser Phe Gly Asn Leu Arg Ala Lys Phe 
        355                 360                 365             


Leu Arg Pro Ser Asp Asp Glu Glu Leu Ser Phe His Ser Lys Gly Arg 
    370                 375                 380                 


Lys Phe Glu Pro Leu Ser Ser Ser Ser Ala Leu Val Ala Gln Gly Ser 
385                 390                 395                 400 


Leu Cys Ser Gly Phe Arg Lys Pro Thr Lys Asn Ser Glu Glu Arg Leu 
                405                 410                 415     


Thr Ser Trp Ser Arg Ser Asp Gly Arg Gly Asp Lys Lys His Ser Asn 
            420                 425                 430         


Gln Lys Pro Ser Glu Thr Ser Thr Asp Glu His Gln His Val Pro Glu 
        435                 440                 445             


Asp Pro Arg Glu Lys Ser Gln Asp Glu Val Leu Arg Asp Asp Pro Pro 
    450                 455                 460                 


Lys Lys Glu His Leu Arg Asp Thr Lys Ser Thr Phe Ala Gly Ser Pro 
465                 470                 475                 480 


Glu Arg Glu Ser Ile His Ile Leu Ser Val Asp Glu Lys Asn Lys Leu 
                485                 490                 495     


Gly Ala Lys Ile Ile Lys Ala Glu Met Met Gly Asn Met Glu Leu Ala 
            500                 505                 510         


Glu Gln Leu Lys Val Gln Leu Glu Lys Ala Asn Lys Phe Lys Glu Thr 
        515                 520                 525             


Ile Thr Gln Ile Pro Lys Lys Ser Gly Val Glu Asn Glu Asp Gln Gln 
    530                 535                 540                 


Glu Val Ile Leu Val Arg Thr Asp Gln Ser Gly Arg Val Trp Pro Val 
545                 550                 555                 560 


Asn Thr Pro Gly Lys Ser Leu Glu Ser Gln Gly Gly Arg Arg Lys Arg 
                565                 570                 575     


Gln Met Val Ser Thr His Glu Glu Arg Glu Arg Val Arg Tyr Phe His 
            580                 585                 590         


Asp Asp Asp Asn Leu Ser Leu Asn Asp Leu Val Lys Asn Glu Lys Met 
        595                 600                 605             


Gly Thr Ala Glu Asn Gln Asn Lys Leu Phe Met Arg Met Ala Ser Lys 
    610                 615                 620                 


Phe Met Gly Lys Thr Asp Gly Asp Tyr Tyr Thr Leu Asp Asp Met Phe 
625                 630                 635                 640 


Val Ser Lys Ala Ala Glu Arg Glu Arg Leu Gly Glu Glu Glu Glu Asn 
                645                 650                 655     


Gln Arg Lys Lys Ala Ile Ala Glu His Arg Ser Leu Ala Ala Gln Met 
            660                 665                 670         


Glu Lys Cys Leu Tyr Cys Phe Asp Ser Ser Gln Phe Pro Lys His Leu 
        675                 680                 685             


Ile Val Ala Ile Gly Val Lys Val Tyr Leu Cys Leu Pro Asn Val Arg 
    690                 695                 700                 


Ser Leu Thr Glu Gly His Cys Leu Ile Val Pro Leu Gln His His Arg 
705                 710                 715                 720 


Ala Ala Thr Leu Leu Asp Glu Asp Ile Trp Glu Glu Ile Gln Met Phe 
                725                 730                 735     


Arg Lys Ser Leu Val Lys Met Phe Glu Asp Lys Gly Leu Asp Cys Ile 
            740                 745                 750         


Phe Leu Glu Thr Asn Met Ser Met Lys Lys Gln Tyr His Met Val Tyr 
        755                 760                 765             


Glu Cys Ile Pro Leu Pro Lys Glu Val Gly Asp Met Ala Pro Ile Tyr 
    770                 775                 780                 


Phe Lys Lys Ala Ile Met Glu Ser Asp Glu Glu Trp Ser Met Asn Lys 
785                 790                 795                 800 


Lys Leu Ile Asp Leu Ser Ser Lys Asp Ile Arg Lys Ser Val Pro Arg 
                805                 810                 815     


Gly Leu Pro Tyr Phe Ser Val Asp Phe Gly Leu His Gly Gly Phe Ala 
            820                 825                 830         


His Val Ile Glu Asp Gln His Lys Phe Pro His Tyr Phe Gly Lys Glu 
        835                 840                 845             


Ile Ile Gly Gly Met Leu Asp Ile Glu Pro Arg Leu Trp Arg Lys Gly 
    850                 855                 860                 


Ile Arg Glu Ser Phe Glu Asp Gln Arg Lys Lys Ala Leu Gln Phe Ala 
865                 870                 875                 880 


Gln Trp Trp Lys Pro Tyr Asp Phe Thr Lys Ser Lys Asn Tyr 
                885                 890                 


<210>  2751
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CWH43__Homo_sapiens__NP_079363

<400>  2751

Met Pro Ser Leu Trp Arg Glu Ile Leu Leu Glu Ser Leu Leu Gly Cys 
1               5                   10                  15      


Val Ser Trp Ser Leu Tyr His Asp Leu Gly Pro Met Ile Tyr Tyr Phe 
            20                  25                  30          


Pro Leu Gln Thr Leu Glu Leu Thr Gly Leu Glu Gly Phe Ser Ile Ala 
        35                  40                  45              


Phe Leu Ser Pro Ile Phe Leu Thr Ile Thr Pro Phe Trp Lys Leu Val 
    50                  55                  60                  


Asn Lys Lys Trp Met Leu Thr Leu Leu Arg Ile Ile Thr Ile Gly Ser 
65                  70                  75                  80  


Ile Ala Ser Phe Gln Ala Pro Asn Ala Lys Leu Arg Leu Met Val Leu 
                85                  90                  95      


Ala Leu Gly Val Ser Ser Ser Leu Ile Val Gln Ala Val Thr Trp Trp 
            100                 105                 110         


Ser Gly Ser His Leu Gln Arg Tyr Leu Arg Ile Trp Gly Phe Ile Leu 
        115                 120                 125             


Gly Gln Ile Val Leu Val Val Leu Arg Ile Trp Tyr Thr Ser Leu Asn 
    130                 135                 140                 


Pro Ile Trp Ser Tyr Gln Met Ser Asn Lys Val Ile Leu Thr Leu Ser 
145                 150                 155                 160 


Ala Ile Ala Thr Leu Asp Arg Ile Gly Thr Asp Gly Asp Cys Ser Lys 
                165                 170                 175     


Pro Glu Glu Lys Lys Thr Gly Glu Val Ala Thr Gly Met Ala Ser Arg 
            180                 185                 190         


Pro Asn Trp Leu Leu Ala Gly Ala Ala Phe Gly Ser Leu Val Phe Leu 
        195                 200                 205             


Thr His Trp Val Phe Gly Glu Val Ser Leu Val Ser Arg Trp Ala Val 
    210                 215                 220                 


Ser Gly His Pro His Pro Gly Pro Asp Pro Asn Pro Phe Gly Gly Ala 
225                 230                 235                 240 


Val Leu Leu Cys Leu Ala Ser Gly Leu Met Leu Pro Ser Cys Leu Trp 
                245                 250                 255     


Phe Arg Gly Thr Gly Leu Ile Trp Trp Val Thr Gly Thr Ala Ser Ala 
            260                 265                 270         


Ala Gly Leu Leu Tyr Leu His Thr Trp Ala Ala Ala Val Ser Gly Cys 
        275                 280                 285             


Val Phe Ala Ile Phe Thr Ala Ser Met Trp Pro Gln Thr Leu Gly His 
    290                 295                 300                 


Leu Ile Asn Ser Gly Thr Asn Pro Gly Lys Thr Met Thr Ile Ala Met 
305                 310                 315                 320 


Ile Phe Tyr Leu Leu Glu Ile Phe Phe Cys Ala Trp Cys Thr Ala Phe 
                325                 330                 335     


Lys Phe Val Pro Gly Gly Val Tyr Ala Arg Glu Arg Ser Asp Val Leu 
            340                 345                 350         


Leu Gly Thr Met Met Leu Ile Ile Gly Leu Asn Met Leu Phe Gly Pro 
        355                 360                 365             


Lys Lys Asn Leu Asp Leu Leu Leu Gln Thr Lys Asn Ser Ser Lys Val 
    370                 375                 380                 


Leu Phe Arg Lys Ser Glu Lys Tyr Met Lys Leu Phe Leu Trp Leu Leu 
385                 390                 395                 400 


Val Gly Val Gly Leu Leu Gly Leu Gly Leu Arg His Lys Ala Tyr Glu 
                405                 410                 415     


Arg Lys Leu Gly Lys Val Ala Pro Thr Lys Glu Val Ser Ala Ala Ile 
            420                 425                 430         


Trp Pro Phe Arg Phe Gly Tyr Asp Asn Glu Gly Trp Ser Ser Leu Glu 
        435                 440                 445             


Arg Ser Ala His Leu Leu Asn Glu Thr Gly Ala Asp Phe Ile Thr Ile 
    450                 455                 460                 


Leu Glu Ser Asp Ala Ser Lys Pro Tyr Met Gly Asn Asn Asp Leu Thr 
465                 470                 475                 480 


Met Trp Leu Gly Glu Lys Leu Gly Phe Tyr Thr Asp Phe Gly Pro Ser 
                485                 490                 495     


Thr Arg Tyr His Thr Trp Gly Ile Met Ala Leu Ser Arg Tyr Pro Ile 
            500                 505                 510         


Val Lys Ser Glu His His Leu Leu Pro Ser Pro Glu Gly Glu Ile Ala 
        515                 520                 525             


Pro Ala Ile Thr Leu Thr Val Asn Ile Ser Gly Lys Leu Val Asp Phe 
    530                 535                 540                 


Val Val Thr His Phe Gly Asn His Glu Asp Asp Leu Asp Arg Lys Leu 
545                 550                 555                 560 


Gln Ala Ile Ala Val Ser Lys Leu Leu Lys Ser Ser Ser Asn Gln Val 
                565                 570                 575     


Ile Phe Leu Gly Tyr Ile Thr Ser Ala Pro Gly Ser Arg Asp Tyr Leu 
            580                 585                 590         


Gln Leu Thr Glu His Gly Asn Val Lys Asp Ile Asp Ser Thr Asp His 
        595                 600                 605             


Asp Arg Trp Cys Glu Tyr Ile Met Tyr Arg Gly Leu Ile Arg Leu Gly 
    610                 615                 620                 


Tyr Ala Arg Ile Ser His Ala Glu Leu Ser Asp Ser Glu Ile Gln Met 
625                 630                 635                 640 


Ala Lys Phe Arg Ile Pro Asp Asp Pro Thr Asn Tyr Arg Asp Asn Gln 
                645                 650                 655     


Lys Val Val Ile Asp His Arg Glu Val Ser Glu Lys Ile His Phe Asn 
            660                 665                 670         


Pro Arg Phe Gly Ser Tyr Lys Glu Gly His Asn Tyr Glu Asn Asn His 
        675                 680                 685             


His Phe His Met Asn Thr Pro Lys Tyr Phe Leu 
    690                 695                 


<210>  2752
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CL1__Homo_sapiens__NP_002987

<400>  2752

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  2753
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1__Homo_sapiens__NP_001164645

<400>  2753

Met Arg Glu Pro Leu Glu Ala Phe Lys Leu Ala Asp Leu Asp Phe Arg 
1               5                   10                  15      


Lys Ser Ser Leu Ala Ser Gly Trp Arg Met Ala Ser Gly Ala Phe Thr 
            20                  25                  30          


Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
        35                  40                  45              


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
    50                  55                  60                  


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
65                  70                  75                  80  


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
                85                  90                  95      


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
            100                 105                 110         


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
        115                 120                 125             


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
    130                 135                 140                 


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
145                 150                 155                 160 


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
                165                 170                 175     


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
            180                 185                 190         


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
        195                 200                 205             


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
    210                 215                 220                 


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
225                 230                 235                 240 


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
                245                 250                 255     


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
            260                 265                 270         


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
        275                 280                 285             


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
    290                 295                 300                 


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
305                 310                 315                 320 


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
                325                 330                 335     


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
            340                 345                 350         


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
        355                 360                 365             


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
    370                 375                 380                 


Leu Leu Leu 
385         


<210>  2754
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXADR__Homo_sapiens__NP_001193993

<400>  2754

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Gly Lys Met Cys His Leu 
    130                 135                 140                 


Gln Arg Ala Val Arg Pro Leu Pro Glu Ala Thr Ser Ala Val Ile Ile 
145                 150                 155                 160 


His Pro Trp Gly Pro Cys Leu Leu Pro Thr Trp Lys Asp Ile Pro Arg 
                165                 170                 175     


Leu Ser Ile Thr Lys Tyr Gln Val Lys Thr Leu Asn Ala Leu Leu Arg 
            180                 185                 190         


Val Arg Leu Ser His Leu Leu Arg 
        195                 200 


<210>  2755
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL10__Homo_sapiens__NP_001556

<400>  2755

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  2756
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL11__Homo_sapiens__NP_005400

<400>  2756

Met Ser Val Lys Gly Met Ala Ile Ala Leu Ala Val Ile Leu Cys Ala 
1               5                   10                  15      


Thr Val Val Gln Gly Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys 
            20                  25                  30          


Ile Gly Pro Gly Val Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala 
        35                  40                  45              


Ser Ile Met Tyr Pro Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile 
    50                  55                  60                  


Thr Leu Lys Glu Asn Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys 
65                  70                  75                  80  


Gln Ala Arg Leu Ile Ile Lys Lys Val Glu Arg Lys Asn Phe 
                85                  90                  


<210>  2757
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12__Homo_sapiens__NP_000600

<400>  2757

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210>  2758
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL13__Homo_sapiens__NP_006410

<400>  2758

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  2759
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL14__Homo_sapiens__NP_004878

<400>  2759

Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 
1               5                   10                  15      


Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val 
            20                  25                  30          


Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 
        35                  40                  45              


Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 
    50                  55                  60                  


Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly 
65                  70                  75                  80  


Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile 
                85                  90                  95      


Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
            100                 105                 110     


<210>  2760
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL16__Homo_sapiens__NP_001094282

<400>  2760

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  2761
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL17__Homo_sapiens__NP_940879

<400>  2761

Met Lys Val Leu Ile Ser Ser Leu Leu Leu Leu Leu Pro Leu Met Leu 
1               5                   10                  15      


Met Ser Met Val Ser Ser Ser Leu Asn Pro Gly Val Ala Arg Gly His 
            20                  25                  30          


Arg Asp Arg Gly Gln Ala Ser Arg Arg Trp Leu Gln Glu Gly Gly Gln 
        35                  40                  45              


Glu Cys Glu Cys Lys Asp Trp Phe Leu Arg Ala Pro Arg Arg Lys Phe 
    50                  55                  60                  


Met Thr Val Ser Gly Leu Pro Lys Lys Gln Cys Pro Cys Asp His Phe 
65                  70                  75                  80  


Lys Gly Asn Val Lys Lys Thr Arg His Gln Arg His His Arg Lys Pro 
                85                  90                  95      


Asn Lys His Ser Arg Ala Cys Gln Gln Phe Leu Lys Gln Cys Gln Leu 
            100                 105                 110         


Arg Ser Phe Ala Leu Pro Leu 
        115                 


<210>  2762
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL1__Homo_sapiens__NP_001502

<400>  2762

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  2763
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL2__Homo_sapiens__NP_002080

<400>  2763

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  2764
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL3__Homo_sapiens__NP_002081

<400>  2764

Met Ala His Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Lys Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile 
                85                  90                  95      


Ile Glu Lys Ile Leu Asn Lys Gly Ser Thr Asn 
            100                 105         


<210>  2765
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL5__Homo_sapiens__NP_002985

<400>  2765

Met Ser Leu Leu Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Ser 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Val Leu Leu Leu Leu Leu Thr Gln Pro Gly 
            20                  25                  30          


Pro Ile Ala Ser Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg 
        35                  40                  45              


Cys Val Cys Leu Gln Thr Thr Gln Gly Val His Pro Lys Met Ile Ser 
    50                  55                  60                  


Asn Leu Gln Val Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys 
            100                 105                 110         


Glu Asn 
        


<210>  2766
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL6__Homo_sapiens__NP_002984

<400>  2766

Met Ser Leu Pro Ser Ser Arg Ala Ala Arg Val Pro Gly Pro Ser Gly 
1               5                   10                  15      


Ser Leu Cys Ala Leu Leu Ala Leu Leu Leu Leu Leu Thr Pro Pro Gly 
            20                  25                  30          


Pro Leu Ala Ser Ala Gly Pro Val Ser Ala Val Leu Thr Glu Leu Arg 
        35                  40                  45              


Cys Thr Cys Leu Arg Val Thr Leu Arg Val Asn Pro Lys Thr Ile Gly 
    50                  55                  60                  


Lys Leu Gln Val Phe Pro Ala Gly Pro Gln Cys Ser Lys Val Glu Val 
65                  70                  75                  80  


Val Ala Ser Leu Lys Asn Gly Lys Gln Val Cys Leu Asp Pro Glu Ala 
                85                  90                  95      


Pro Phe Leu Lys Lys Val Ile Gln Lys Ile Leu Asp Ser Gly Asn Lys 
            100                 105                 110         


Lys Asn 
        


<210>  2767
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL8__Homo_sapiens__NP_000575

<400>  2767

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  2768
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL9__Homo_sapiens__NP_002407

<400>  2768

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  2769
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR1__Homo_sapiens__NP_000625

<400>  2769

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  2770
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR2__Homo_sapiens__NP_001161770

<400>  2770

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  2771
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3__Homo_sapiens__NP_001136269

<400>  2771

Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Thr Val Ile 
1               5                   10                  15      


Gly Gly Ala Ala Gln Ser Lys Ser Gln Thr Lys Ser Asp Ser Ile Thr 
            20                  25                  30          


Lys Glu Phe Leu Pro Gly Leu Tyr Thr Ala Pro Ser Ser Pro Phe Pro 
        35                  40                  45              


Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala 
    50                  55                  60                  


Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu 
65                  70                  75                  80  


Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
                85                  90                  95      


Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu 
            100                 105                 110         


Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Arg 
        115                 120                 125             


Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val 
    130                 135                 140                 


Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala 
145                 150                 155                 160 


Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala 
                165                 170                 175     


Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile 
            180                 185                 190         


Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg 
        195                 200                 205             


Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp Gly 
    210                 215                 220                 


Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala His 
225                 230                 235                 240 


His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln 
                245                 250                 255     


Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu 
            260                 265                 270         


Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val 
        275                 280                 285             


Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val 
    290                 295                 300                 


Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His Leu 
305                 310                 315                 320 


Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn 
                325                 330                 335     


Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser Gly 
            340                 345                 350         


Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val 
        355                 360                 365             


Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
    370                 375                 380                 


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
385                 390                 395                 400 


Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
                405                 410                 415 


<210>  2772
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4__Homo_sapiens__NP_001008540

<400>  2772

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  2773
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR5__Homo_sapiens__NP_001707

<400>  2773

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  2774
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR6__Homo_sapiens__NP_006555

<400>  2774

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  2775
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXorf36__Homo_sapiens__NP_078965

<400>  2775

Met Glu Pro Gln Leu Gly Pro Glu Ala Ala Ala Leu Arg Pro Gly Trp 
1               5                   10                  15      


Leu Ala Leu Leu Leu Trp Val Ser Ala Leu Ser Cys Ser Phe Ser Leu 
            20                  25                  30          


Pro Ala Ser Ser Leu Ser Ser Leu Val Pro Gln Val Arg Thr Ser Tyr 
        35                  40                  45              


Asn Phe Gly Arg Thr Phe Leu Gly Leu Asp Lys Cys Asn Ala Cys Ile 
    50                  55                  60                  


Gly Thr Ser Ile Cys Lys Lys Phe Phe Lys Glu Glu Ile Arg Ser Asp 
65                  70                  75                  80  


Asn Trp Leu Ala Ser His Leu Gly Leu Pro Pro Asp Ser Leu Leu Ser 
                85                  90                  95      


Tyr Pro Ala Asn Tyr Ser Asp Asp Ser Lys Ile Trp Arg Pro Val Glu 
            100                 105                 110         


Ile Phe Arg Leu Val Ser Lys Tyr Gln Asn Glu Ile Ser Asp Arg Arg 
        115                 120                 125             


Ile Cys Ala Ser Ala Ser Ala Pro Lys Thr Cys Ser Ile Glu Arg Val 
    130                 135                 140                 


Leu Arg Lys Thr Glu Arg Phe Gln Lys Trp Leu Gln Ala Lys Arg Leu 
145                 150                 155                 160 


Thr Pro Asp Leu Val Gln Asp Cys His Gln Gly Gln Arg Glu Leu Lys 
                165                 170                 175     


Phe Leu Cys Met Leu Arg 
            180         


<210>  2776
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXorf66__Homo_sapiens__NP_001013421

<400>  2776

Met Asn Leu Val Ile Cys Val Leu Leu Leu Ser Ile Trp Lys Asn Asn 
1               5                   10                  15      


Cys Met Thr Thr Asn Gln Thr Asn Gly Ser Ser Thr Thr Gly Asp Lys 
            20                  25                  30          


Pro Val Glu Ser Met Gln Thr Lys Leu Asn Tyr Leu Arg Arg Asn Leu 
        35                  40                  45              


Leu Ile Leu Val Gly Ile Ile Ile Met Val Phe Val Phe Ile Cys Phe 
    50                  55                  60                  


Cys Tyr Leu His Tyr Asn Cys Leu Ser Asp Asp Ala Ser Lys Ala Gly 
65                  70                  75                  80  


Met Val Lys Lys Lys Gly Ile Ala Ala Lys Ser Ser Lys Thr Ser Phe 
                85                  90                  95      


Ser Glu Ala Lys Thr Ala Ser Gln Cys Ser Pro Glu Thr Gln Pro Met 
            100                 105                 110         


Leu Ser Thr Ala Asp Lys Ser Ser Asp Ser Ser Ser Pro Glu Arg Ala 
        115                 120                 125             


Ser Ala Gln Ser Ser Thr Glu Lys Leu Ile Arg Pro Ser Ser Leu Gln 
    130                 135                 140                 


Lys Pro Ser Ile Pro Asn Ser Ala Gly Lys Leu Thr Arg Pro Ser Tyr 
145                 150                 155                 160 


Pro Lys Arg Ser Ser Lys Ser Ser Cys Ser Lys Lys Leu Ser Lys Ser 
                165                 170                 175     


Ser His Leu Glu Lys Ala His Lys Lys Gly Ser Leu Glu Lys Leu Cys 
            180                 185                 190         


Lys Leu Asp Tyr Ala Cys Lys Leu Ala Ser Ser Asp Lys Pro Val Arg 
        195                 200                 205             


Pro Pro Gln Leu Phe Lys Pro Leu Tyr Ser Ser His Pro Gln Asn Glu 
    210                 215                 220                 


Ile Ser Pro Ser Lys Pro Phe Gly Pro Gln Glu Leu Ala Lys Pro Pro 
225                 230                 235                 240 


Lys His Phe Asn Pro Lys Arg Ser Val Ser Leu Gly Arg Ala Ala Leu 
                245                 250                 255     


Leu Ser Asn Ser Glu Leu Ala Glu Thr Cys Gln Pro Tyr Lys Lys Lys 
            260                 265                 270         


His Leu Val Ala Lys Thr Tyr Arg Pro Leu Val Asn Asp Ile Ser Glu 
        275                 280                 285             


Ala Lys Glu Lys Asn Thr Gln Asn Leu His Val Ser Ser Lys Val Lys 
    290                 295                 300                 


Ser Ser Ser Arg Ser Phe Arg Lys Leu Asp Ser Arg Asn Asn Ala Tyr 
305                 310                 315                 320 


Gly Asp His Val Asn Asp Ser Asp Thr Met Lys Tyr Tyr Ser Glu Val 
                325                 330                 335     


Asp Ser Asp Lys Val Ile Ile Ile Thr Cys Asp Arg Gly Tyr Asn Gln 
            340                 345                 350         


Val Thr Ser Glu Val Thr Leu Asn Asp 
        355                 360     


<210>  2777
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXorf67__Homo_sapiens__NP_981952

<400>  2777

Met Ala Thr Gln Ser Asp Met Glu Lys Glu Gln Lys His Gln Gln Asp 
1               5                   10                  15      


Glu Gly Gln Gly Gly Leu Asn Asn Glu Thr Ala Leu Ala Ser Gly Asp 
            20                  25                  30          


Ala Cys Gly Thr Gly Asn Gln Asp Pro Ala Ala Ser Val Thr Thr Val 
        35                  40                  45              


Ser Ser Gln Ala Ser Pro Ser Gly Gly Ala Ala Leu Ser Ser Ser Thr 
    50                  55                  60                  


Ala Gly Ser Ser Ala Ala Ala Ala Thr Ser Ala Ala Ile Phe Ile Thr 
65                  70                  75                  80  


Asp Glu Ala Ser Gly Leu Pro Ile Ile Ala Ala Val Leu Thr Glu Arg 
                85                  90                  95      


His Ser Asp Arg Gln Asp Cys Arg Ser Pro His Glu Val Phe Gly Cys 
            100                 105                 110         


Val Val Pro Glu Gly Gly Ser Gln Ala Ala Val Gly Pro Gln Lys Ala 
        115                 120                 125             


Thr Gly His Ala Asp Glu His Leu Ala Gln Thr Lys Ser Pro Gly Asn 
    130                 135                 140                 


Ser Arg Arg Arg Lys Gln Pro Cys Arg Asn Gln Ala Ala Pro Ala Gln 
145                 150                 155                 160 


Lys Pro Pro Gly Arg Arg Leu Phe Pro Glu Pro Leu Pro Pro Ser Ser 
                165                 170                 175     


Pro Gly Phe Arg Pro Ser Ser Tyr Pro Cys Ser Gly Ala Ser Thr Ser 
            180                 185                 190         


Ser Gln Ala Thr Gln Pro Gly Pro Ala Leu Leu Ser His Ala Ser Glu 
        195                 200                 205             


Ala Arg Pro Ala Thr Arg Ser Arg Ile Thr Leu Val Ala Ser Ala Leu 
    210                 215                 220                 


Arg Arg Arg Ala Ser Gly Pro Gly Pro Val Ile Arg Gly Cys Thr Ala 
225                 230                 235                 240 


Gln Pro Gly Pro Ala Phe Pro His Arg Ala Thr His Leu Asp Pro Ala 
                245                 250                 255     


Arg Leu Ser Pro Glu Ser Ala Pro Gly Pro Ala Arg Arg Gly Arg Ala 
            260                 265                 270         


Ser Val Pro Gly Pro Ala Arg Arg Gly Cys Asp Ser Ala Pro Gly Pro 
        275                 280                 285             


Ala Arg Arg Gly Arg Asp Ser Ala Pro Val Ser Ala Pro Arg Gly Arg 
    290                 295                 300                 


Asp Ser Ala Pro Gly Ser Ala Arg Arg Gly Arg Asp Ser Ala Pro Gly 
305                 310                 315                 320 


Pro Ala Leu Arg Val Arg Thr Ala Arg Ser Asp Ala Gly His Arg Ser 
                325                 330                 335     


Thr Ser Thr Thr Pro Gly Thr Gly Leu Arg Ser Arg Ser Thr Gln Gln 
            340                 345                 350         


Arg Ser Ala Leu Leu Ser Arg Arg Ser Leu Ser Gly Ser Ala Asp Glu 
        355                 360                 365             


Asn Pro Ser Cys Gly Thr Gly Ser Glu Arg Leu Ala Phe Gln Ser Arg 
    370                 375                 380                 


Ser Gly Ser Pro Asp Pro Glu Val Pro Ser Arg Ala Ser Pro Pro Val 
385                 390                 395                 400 


Trp His Ala Val Arg Met Arg Ala Ser Ser Pro Ser Pro Pro Gly Arg 
                405                 410                 415     


Phe Phe Leu Pro Ile Pro Gln Gln Trp Asp Glu Ser Ser Ser Ser Ser 
            420                 425                 430         


Tyr Ala Ser Asn Ser Ser Ser Pro Ser Arg Ser Pro Gly Leu Ser Pro 
        435                 440                 445             


Ser Ser Pro Ser Pro Glu Phe Leu Gly Leu Arg Ser Ile Ser Thr Pro 
    450                 455                 460                 


Ser Pro Glu Ser Leu Arg Tyr Ala Leu Met Pro Glu Phe Tyr Ala Leu 
465                 470                 475                 480 


Ser Pro Val Pro Pro Glu Glu Gln Ala Glu Ile Glu Ser Thr Ala His 
                485                 490                 495     


Pro Ala Thr Pro Pro Glu Pro 
            500             


<210>  2778
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXXC1__Homo_sapiens__NP_001095124

<400>  2778

Met Glu Gly Asp Gly Ser Asp Pro Glu Pro Pro Asp Ala Gly Glu Asp 
1               5                   10                  15      


Ser Lys Ser Glu Asn Gly Glu Asn Ala Pro Ile Tyr Cys Ile Cys Arg 
            20                  25                  30          


Lys Pro Asp Ile Asn Cys Phe Met Ile Gly Cys Asp Asn Cys Asn Glu 
        35                  40                  45              


Trp Phe His Gly Asp Cys Ile Arg Ile Thr Glu Lys Met Ala Lys Ala 
    50                  55                  60                  


Ile Arg Glu Trp Tyr Cys Arg Glu Cys Arg Glu Lys Asp Pro Lys Leu 
65                  70                  75                  80  


Glu Ile Arg Tyr Arg His Lys Lys Ser Arg Glu Arg Asp Gly Asn Glu 
                85                  90                  95      


Arg Asp Ser Ser Glu Pro Arg Asp Glu Gly Gly Gly Arg Lys Arg Pro 
            100                 105                 110         


Val Pro Asp Pro Asp Leu Gln Arg Arg Ala Gly Ser Gly Thr Gly Val 
        115                 120                 125             


Gly Ala Met Leu Ala Arg Gly Ser Ala Ser Pro His Lys Ser Ser Pro 
    130                 135                 140                 


Gln Pro Leu Val Ala Thr Pro Ser Gln His His Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Ile Lys Arg Ser Ala Arg Met Cys Gly Glu Cys Glu Ala Cys Arg 
                165                 170                 175     


Arg Thr Glu Asp Cys Gly His Cys Asp Phe Cys Arg Asp Met Lys Lys 
            180                 185                 190         


Phe Gly Gly Pro Asn Lys Ile Arg Gln Lys Cys Arg Leu Arg Gln Cys 
        195                 200                 205             


Gln Leu Arg Ala Arg Glu Ser Tyr Lys Tyr Phe Pro Ser Ser Leu Ser 
    210                 215                 220                 


Pro Val Thr Pro Ser Glu Ser Leu Pro Arg Pro Arg Arg Pro Leu Pro 
225                 230                 235                 240 


Thr Gln Gln Gln Pro Gln Pro Ser Gln Lys Leu Gly Arg Ile Arg Glu 
                245                 250                 255     


Asp Glu Gly Ala Val Ala Ser Ser Thr Val Lys Glu Pro Pro Glu Ala 
            260                 265                 270         


Thr Ala Thr Pro Glu Pro Leu Ser Asp Glu Asp Leu Pro Leu Asp Pro 
        275                 280                 285             


Asp Leu Tyr Gln Asp Phe Cys Ala Gly Ala Phe Asp Asp His Gly Leu 
    290                 295                 300                 


Pro Trp Met Ser Asp Thr Glu Glu Ser Pro Phe Leu Asp Pro Ala Leu 
305                 310                 315                 320 


Arg Lys Arg Ala Val Lys Val Lys His Val Lys Arg Arg Glu Lys Lys 
                325                 330                 335     


Ser Glu Lys Lys Val Met Glu Arg Lys Glu Glu Arg Tyr Lys Arg His 
            340                 345                 350         


Arg Gln Lys Gln Lys His Lys Asp Lys Trp Lys His Pro Glu Arg Ala 
        355                 360                 365             


Asp Ala Lys Asp Pro Ala Ser Leu Pro Gln Cys Leu Gly Pro Gly Cys 
    370                 375                 380                 


Val Arg Pro Ala Gln Pro Ser Ser Lys Tyr Cys Ser Asp Asp Cys Gly 
385                 390                 395                 400 


Met Lys Leu Ala Ala Asn Arg Ile Tyr Glu Ile Leu Pro Gln Arg Ile 
                405                 410                 415     


Gln Gln Trp Gln Gln Ser Pro Cys Ile Ala Glu Glu His Gly Lys Lys 
            420                 425                 430         


Leu Leu Glu Arg Ile Arg Arg Glu Gln Gln Ser Ala Arg Thr Arg Leu 
        435                 440                 445             


Gln Glu Met Glu Arg Arg Phe His Glu Leu Glu Ala Ile Ile Leu Arg 
    450                 455                 460                 


Ala Lys Gln Gln Ala Val Arg Glu Asp Glu Glu Ser Asn Glu Gly Asp 
465                 470                 475                 480 


Ser Asp Asp Thr Asp Leu Gln Ile Phe Cys Val Ser Cys Gly His Pro 
                485                 490                 495     


Ile Asn Pro Arg Val Ala Leu Arg His Met Glu Arg Cys Tyr Ala Lys 
            500                 505                 510         


Tyr Glu Ser Gln Thr Ser Phe Gly Ser Met Tyr Pro Thr Arg Ile Glu 
        515                 520                 525             


Gly Ala Thr Arg Leu Phe Cys Asp Val Tyr Asn Pro Gln Ser Lys Thr 
    530                 535                 540                 


Tyr Cys Lys Arg Leu Gln Val Leu Cys Pro Glu His Ser Arg Asp Pro 
545                 550                 555                 560 


Lys Val Pro Ala Asp Glu Val Cys Gly Cys Pro Leu Val Arg Asp Val 
                565                 570                 575     


Phe Glu Leu Thr Gly Asp Phe Cys Arg Leu Pro Lys Arg Gln Cys Asn 
            580                 585                 590         


Arg His Tyr Cys Trp Glu Lys Leu Arg Arg Ala Glu Val Asp Leu Glu 
        595                 600                 605             


Arg Val Arg Val Trp Tyr Lys Leu Asp Glu Leu Phe Glu Gln Glu Arg 
    610                 615                 620                 


Asn Val Arg Thr Ala Met Thr Asn Arg Ala Gly Leu Leu Ala Leu Met 
625                 630                 635                 640 


Leu His Gln Thr Ile Gln His Asp Pro Leu Thr Thr Asp Leu Arg Ser 
                645                 650                 655     


Ser Ala Asp Arg 
            660 


<210>  2779
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXXC4__Homo_sapiens__NP_079488

<400>  2779

Met Asn Thr Asn Val Cys Val Glu Pro Gly Pro Ser Pro Glu Ala Pro 
1               5                   10                  15      


Gly Leu Pro Lys Glu Ser His Leu Pro Glu Gly Ala Leu Asn Ser Leu 
            20                  25                  30          


Val Asp Tyr Asn Ser Glu Met Glu Arg Tyr Arg Ser Phe Ala Thr Ser 
        35                  40                  45              


Phe Tyr Lys Thr Asn Gly Gly Ala Phe Pro Gln Ala Ala Lys Ile Ala 
    50                  55                  60                  


Arg Ile Thr Thr Pro Ile Phe Pro Ser Ser Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Arg Ile Gly Met Ser Pro Trp Asn Cys Asp Asn Ala Ala Thr 
                85                  90                  95      


Ala Ala Ala Ala Thr Ala Met Leu Trp Gly Ser Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Gly Arg Lys Ser Ser Ser Ala Ala Ala Ser Ser 
    130                 135                 140                 


Ser Ala Ser Ser Ser Ser Ala Ile Leu Pro Ala Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Ser Arg Thr Ser Met His His Arg Asn Asp Ser 
                165                 170                 175     


Gln Arg Leu Gly Lys Ala Gly Cys Pro Pro Glu Pro Ser Leu Gln Met 
            180                 185                 190         


Ala Asn Thr Asn Phe Leu Ser Thr Leu Ser Pro Glu His Cys Arg Pro 
        195                 200                 205             


Leu Ala Gly Glu Cys Met Asn Lys Leu Lys Cys Gly Ala Ala Glu Ala 
    210                 215                 220                 


Glu Ile Met Asn Leu Pro Glu Arg Val Gly Thr Phe Ser Ala Ile Pro 
225                 230                 235                 240 


Ala Leu Gly Gly Ile Ser Leu Pro Pro Gly Val Ile Val Met Thr Ala 
                245                 250                 255     


Leu His Ser Pro Ala Ala Ala Ser Ala Ala Val Thr Asp Ser Ala Phe 
            260                 265                 270         


Gln Ile Ala Asn Leu Ala Asp Cys Pro Gln Asn His Ser Ser Ser Ser 
        275                 280                 285             


Ser Ser Ser Ser Gly Gly Ala Gly Gly Ala Asn Pro Ala Lys Lys Lys 
    290                 295                 300                 


Arg Lys Arg Cys Gly Val Cys Val Pro Cys Lys Arg Leu Ile Asn Cys 
305                 310                 315                 320 


Gly Val Cys Ser Ser Cys Arg Asn Arg Lys Thr Gly His Gln Ile Cys 
                325                 330                 335     


Lys Phe Arg Lys Cys Glu Glu Leu Lys Lys Lys Pro Gly Thr Ser Leu 
            340                 345                 350         


Glu Arg Thr Pro Val Pro Ser Ala Glu Ala Phe Arg Trp Phe Phe 
        355                 360                 365         


<210>  2780
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYB561D2__Homo_sapiens__NP_001278213

<400>  2780

Met Ala Leu Ser Ala Glu Thr Glu Ser His Ile Tyr Arg Ala Leu Arg 
1               5                   10                  15      


Thr Ala Ser Gly Ala Ala Ala His Leu Val Ala Leu Gly Phe Thr Ile 
            20                  25                  30          


Phe Val Ala Val Leu Ala Arg Pro Gly Ser Ser Leu Phe Ser Trp His 
        35                  40                  45              


Pro Val Leu Met Ser Leu Ala Phe Ser Phe Leu Met Thr Glu Ala Leu 
    50                  55                  60                  


Leu Val Phe Ser Pro Glu Ser Ser Leu Leu His Ser Leu Ser Arg Lys 
65                  70                  75                  80  


Gly Arg Ala Arg Cys His Trp Val Leu Gln Leu Leu Ala Leu Leu Cys 
                85                  90                  95      


Ala Leu Leu Gly Leu Gly Leu Val Ile Leu His Lys Glu Gln Leu Gly 
            100                 105                 110         


Lys Ala His Leu Val Thr Arg His Gly Gln Ala Gly Leu Leu Ala Val 
        115                 120                 125             


Leu Trp Ala Gly Leu Gln Cys Ser Gly Gly Val Gly Leu Leu Tyr Pro 
    130                 135                 140                 


Lys Leu Leu Pro Arg Trp Pro Leu Ala Lys Leu Lys Leu Tyr His Ala 
145                 150                 155                 160 


Thr Ser Gly Leu Val Gly Tyr Leu Leu Gly Ser Ala Ser Leu Leu Leu 
                165                 170                 175     


Gly Met Cys Ser Leu Trp Phe Thr Ala Ser Val Thr Gly Ala Ala Trp 
            180                 185                 190         


Tyr Leu Ala Val Leu Cys Pro Val Leu Thr Ser Leu Val Ile Met Asn 
        195                 200                 205             


Gln Val Ser Asn Ala Tyr Leu Tyr Arg Lys Arg Ile Gln Pro 
    210                 215                 220         


<210>  2781
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYB561__Homo_sapiens__XP_005257148

<400>  2781

Met Glu Gly Gly Ala Ala Ala Ala Thr Pro Thr Ala Leu Pro Tyr Tyr 
1               5                   10                  15      


Val Ala Phe Ser Gln Leu Leu Gly Leu Thr Leu Val Ala Met Thr Gly 
            20                  25                  30          


Ala Trp Leu Gly Leu Tyr Arg Gly Gly Ile Ala Trp Glu Ser Asp Leu 
        35                  40                  45              


Gln Phe Asn Ala His Pro Leu Cys Met Val Ile Gly Leu Ile Phe Leu 
    50                  55                  60                  


Gln Gly Asn Ala Leu Leu Val Tyr Arg Val Phe Arg Asn Glu Ala Lys 
65                  70                  75                  80  


Arg Thr Thr Lys Val Leu His Gly Leu Leu His Ile Phe Ala Leu Val 
                85                  90                  95      


Ile Ala Leu Val Gly Leu Val Ala Val Phe Asp Tyr His Arg Lys Lys 
            100                 105                 110         


Gly Tyr Ala Asp Leu Tyr Ser Leu His Ser Trp Cys Gly Ile Leu Val 
        115                 120                 125             


Phe Val Leu Tyr Phe Val Gln Trp Leu Val Gly Phe Ser Phe Phe Leu 
    130                 135                 140                 


Phe Pro Gly Ala Ser Phe Ser Leu Arg Ser Arg Tyr Arg Pro Gln His 
145                 150                 155                 160 


Ile Phe Phe Gly Ala Thr Ile Phe Leu Leu Ser Val Gly Thr Ala Leu 
                165                 170                 175     


Leu Gly Leu Lys Glu Ala Leu Leu Phe Asn Leu Gly Gly Lys Tyr Ser 
            180                 185                 190         


Ala Phe Glu Pro Glu Gly Val Leu Ala Asn Val Leu Gly Leu Leu Leu 
        195                 200                 205             


Ala Cys Phe Gly Gly Ala Val Leu Tyr Ile Leu Thr Arg Ala Asp Trp 
    210                 215                 220                 


Lys Arg Pro Ser Gln Ala Glu Glu Gln Ala Leu Ser Met Asp Phe Lys 
225                 230                 235                 240 


Thr Leu Thr Glu Gly Asp Ser Pro Gly Ser Gln 
                245                 250     


<210>  2782
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYB5A__Homo_sapiens__NP_001177736

<400>  2782

Met Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu 
1               5                   10                  15      


Ile Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His 
            20                  25                  30          


Lys Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu 
        35                  40                  45              


Glu Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu 
    50                  55                  60                  


Asp Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile 
65                  70                  75                  80  


Ile Gly Glu Leu His Pro Glu Thr Leu Ile Thr Thr Ile Asp Ser Ser 
                85                  90                  95      


Ser Ser Trp Trp Thr Asn Trp Val Ile Pro Ala Ile Ser Ala Val Ala 
            100                 105                 110         


Val Ala Leu Met Tyr Arg Leu Tyr Met Ala Glu Asp 
        115                 120                 


<210>  2783
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYB5B__Homo_sapiens__NP_085056

<400>  2783

Met Ser Gly Ser Met Ala Thr Ala Glu Ala Ser Gly Ser Asp Gly Lys 
1               5                   10                  15      


Gly Gln Glu Val Glu Thr Ser Val Thr Tyr Tyr Arg Leu Glu Glu Val 
            20                  25                  30          


Ala Lys Arg Asn Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg 
        35                  40                  45              


Val Tyr Asp Val Thr Arg Phe Leu Asn Glu His Pro Gly Gly Glu Glu 
    50                  55                  60                  


Val Leu Leu Glu Gln Ala Gly Val Asp Ala Ser Glu Ser Phe Glu Asp 
65                  70                  75                  80  


Val Gly His Ser Ser Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile 
                85                  90                  95      


Gly Asp Ile His Pro Ser Asp Leu Lys Pro Glu Ser Gly Ser Lys Asp 
            100                 105                 110         


Pro Ser Lys Asn Asp Thr Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu 
        115                 120                 125             


Pro Ile Ile Gly Ala Val Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr 
    130                 135                 140                 


Ser Glu Ser Lys Ser Ser 
145                 150 


<210>  2784
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYB5R3__Homo_sapiens__NP_000389

<400>  2784

Met Gly Ala Gln Leu Ser Thr Leu Gly His Met Val Leu Phe Pro Val 
1               5                   10                  15      


Trp Phe Leu Tyr Ser Leu Leu Met Lys Leu Phe Gln Arg Ser Thr Pro 
            20                  25                  30          


Ala Ile Thr Leu Glu Ser Pro Asp Ile Lys Tyr Pro Leu Arg Leu Ile 
        35                  40                  45              


Asp Arg Glu Ile Ile Ser His Asp Thr Arg Arg Phe Arg Phe Ala Leu 
    50                  55                  60                  


Pro Ser Pro Gln His Ile Leu Gly Leu Pro Val Gly Gln His Ile Tyr 
65                  70                  75                  80  


Leu Ser Ala Arg Ile Asp Gly Asn Leu Val Val Arg Pro Tyr Thr Pro 
                85                  90                  95      


Ile Ser Ser Asp Asp Asp Lys Gly Phe Val Asp Leu Val Ile Lys Val 
            100                 105                 110         


Tyr Phe Lys Asp Thr His Pro Lys Phe Pro Ala Gly Gly Lys Met Ser 
        115                 120                 125             


Gln Tyr Leu Glu Ser Met Gln Ile Gly Asp Thr Ile Glu Phe Arg Gly 
    130                 135                 140                 


Pro Ser Gly Leu Leu Val Tyr Gln Gly Lys Gly Lys Phe Ala Ile Arg 
145                 150                 155                 160 


Pro Asp Lys Lys Ser Asn Pro Ile Ile Arg Thr Val Lys Ser Val Gly 
                165                 170                 175     


Met Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu Gln Val Ile Arg 
            180                 185                 190         


Ala Ile Met Lys Asp Pro Asp Asp His Thr Val Cys His Leu Leu Phe 
        195                 200                 205             


Ala Asn Gln Thr Glu Lys Asp Ile Leu Leu Arg Pro Glu Leu Glu Glu 
    210                 215                 220                 


Leu Arg Asn Lys His Ser Ala Arg Phe Lys Leu Trp Tyr Thr Leu Asp 
225                 230                 235                 240 


Arg Ala Pro Glu Ala Trp Asp Tyr Gly Gln Gly Phe Val Asn Glu Glu 
                245                 250                 255     


Met Ile Arg Asp His Leu Pro Pro Pro Glu Glu Glu Pro Leu Val Leu 
            260                 265                 270         


Met Cys Gly Pro Pro Pro Met Ile Gln Tyr Ala Cys Leu Pro Asn Leu 
        275                 280                 285             


Asp His Val Gly His Pro Thr Glu Arg Cys Phe Val Phe 
    290                 295                 300     


<210>  2785
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYB5R4__Homo_sapiens__NP_057314

<400>  2785

Met Leu Asn Val Pro Ser Gln Ser Phe Pro Ala Pro Arg Ser Gln Gln 
1               5                   10                  15      


Arg Val Ala Ser Gly Gly Arg Ser Lys Val Pro Leu Lys Gln Gly Arg 
            20                  25                  30          


Ser Leu Met Asp Trp Ile Arg Leu Thr Lys Ser Gly Lys Asp Leu Thr 
        35                  40                  45              


Gly Leu Lys Gly Arg Leu Ile Glu Val Thr Glu Glu Glu Leu Lys Lys 
    50                  55                  60                  


His Asn Lys Lys Asp Asp Cys Trp Ile Cys Ile Arg Gly Phe Val Tyr 
65                  70                  75                  80  


Asn Val Ser Pro Tyr Met Glu Tyr His Pro Gly Gly Glu Asp Glu Leu 
                85                  90                  95      


Met Arg Ala Ala Gly Ser Asp Gly Thr Glu Leu Phe Asp Gln Val His 
            100                 105                 110         


Arg Trp Val Asn Tyr Glu Ser Met Leu Lys Glu Cys Leu Val Gly Arg 
        115                 120                 125             


Met Ala Ile Lys Pro Ala Val Leu Lys Asp Tyr Arg Glu Glu Glu Lys 
    130                 135                 140                 


Lys Val Leu Asn Gly Met Leu Pro Lys Ser Gln Val Thr Asp Thr Leu 
145                 150                 155                 160 


Ala Lys Glu Gly Pro Ser Tyr Pro Ser Tyr Asp Trp Phe Gln Thr Asp 
                165                 170                 175     


Ser Leu Val Thr Ile Ala Ile Tyr Thr Lys Gln Lys Asp Ile Asn Leu 
            180                 185                 190         


Asp Ser Ile Ile Val Asp His Gln Asn Asp Ser Phe Arg Ala Glu Thr 
        195                 200                 205             


Ile Ile Lys Asp Cys Leu Tyr Leu Ile His Ile Gly Leu Ser His Glu 
    210                 215                 220                 


Val Gln Glu Asp Phe Ser Val Arg Val Val Glu Ser Val Gly Lys Ile 
225                 230                 235                 240 


Glu Ile Val Leu Gln Lys Lys Glu Asn Thr Ser Trp Asp Phe Leu Gly 
                245                 250                 255     


His Pro Leu Lys Asn His Asn Ser Leu Ile Pro Arg Lys Asp Thr Gly 
            260                 265                 270         


Leu Tyr Tyr Arg Lys Cys Gln Leu Ile Ser Lys Glu Asp Val Thr His 
        275                 280                 285             


Asp Thr Arg Leu Phe Cys Leu Met Leu Pro Pro Ser Thr His Leu Gln 
    290                 295                 300                 


Val Pro Ile Gly Gln His Val Tyr Leu Lys Leu Pro Ile Thr Gly Thr 
305                 310                 315                 320 


Glu Ile Val Lys Pro Tyr Thr Pro Val Ser Gly Ser Leu Leu Ser Glu 
                325                 330                 335     


Phe Lys Glu Pro Val Leu Pro Asn Asn Lys Tyr Ile Tyr Phe Leu Ile 
            340                 345                 350         


Lys Ile Tyr Pro Thr Gly Leu Phe Thr Pro Glu Leu Asp Arg Leu Gln 
        355                 360                 365             


Ile Gly Asp Phe Val Ser Val Ser Ser Pro Glu Gly Asn Phe Lys Ile 
    370                 375                 380                 


Ser Lys Phe Gln Glu Leu Glu Asp Leu Phe Leu Leu Ala Ala Gly Thr 
385                 390                 395                 400 


Gly Phe Thr Pro Met Val Lys Ile Leu Asn Tyr Ala Leu Thr Asp Ile 
                405                 410                 415     


Pro Ser Leu Arg Lys Val Lys Leu Met Phe Phe Asn Lys Thr Glu Asp 
            420                 425                 430         


Asp Ile Ile Trp Arg Ser Gln Leu Glu Lys Leu Ala Phe Lys Asp Lys 
        435                 440                 445             


Arg Leu Asp Val Glu Phe Val Leu Ser Ala Pro Ile Ser Glu Trp Asn 
    450                 455                 460                 


Gly Lys Gln Gly His Ile Ser Pro Ala Leu Leu Ser Glu Phe Leu Lys 
465                 470                 475                 480 


Arg Asn Leu Asp Lys Ser Lys Val Leu Val Cys Ile Cys Gly Pro Val 
                485                 490                 495     


Pro Phe Thr Glu Gln Gly Val Arg Leu Leu His Asp Leu Asn Phe Ser 
            500                 505                 510         


Lys Asn Glu Ile His Ser Phe Thr Ala 
        515                 520     


<210>  2786
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYBA__Homo_sapiens__NP_000092

<400>  2786

Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Thr Gly Gly Ile Val Ala Thr Ala Gly Arg 
            20                  25                  30          


Phe Thr Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Thr 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Thr Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Thr Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Thr Ile Leu Gly Thr Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ala Ala Val Arg Gly 
        115                 120                 125             


Glu Gln Trp Thr Pro Ile Glu Pro Lys Pro Arg Glu Arg Pro Gln Ile 
    130                 135                 140                 


Gly Gly Thr Ile Lys Gln Pro Pro Ser Asn Pro Pro Pro Arg Pro Pro 
145                 150                 155                 160 


Ala Glu Ala Arg Lys Lys Pro Ser Glu Glu Glu Ala Ala Val Ala Ala 
                165                 170                 175     


Gly Gly Pro Pro Gly Gly Pro Gln Val Asn Pro Ile Pro Val Thr Asp 
            180                 185                 190         


Glu Val Val 
        195 


<210>  2787
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYBB__Homo_sapiens__NP_000388

<400>  2787

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  2788
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYBRD1__Homo_sapiens__NP_001120855

<400>  2788

Met Ala Met Glu Gly Tyr Trp Arg Phe Leu Ala Leu Leu Gly Ser Ala 
1               5                   10                  15      


Leu Leu Val Gly Phe Leu Ser Val Ile Phe Ala Leu Val Trp Val Leu 
            20                  25                  30          


His Tyr Arg Glu Gly Leu Gly Trp Asp Gly Ser Ala Leu Glu Phe Asn 
        35                  40                  45              


Trp His Pro Val Leu Met Val Thr Gly Phe Val Phe Ile Gln Gly Ile 
    50                  55                  60                  


Ala Ser Phe Arg Phe Phe Ser Leu Ser Ala Ser Met Gly Ser Ala Phe 
65                  70                  75                  80  


Ser Pro Ser Ile Ser His Ala His Thr Cys Leu Phe Trp Asn Cys His 
                85                  90                  95      


Leu Trp Asn Ser Asp Cys Asn Ser Thr Tyr Gly Ile Asp Arg Glu Thr 
            100                 105                 110         


Asp Phe Phe Pro Glu Arg Ser Cys Ile Gln Tyr Ile Pro Ala Arg Arg 
        115                 120                 125             


Cys Phe Arg Lys Tyr Ala Trp Pro Ser Asp Pro Gly Val Arg Gly Pro 
    130                 135                 140                 


His Phe Leu Asp Ser His Gln Thr Ala Met Glu Thr Ser 
145                 150                 155         


<210>  2789
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYC1__Homo_sapiens__NP_001907

<400>  2789

Met Ala Ala Ala Ala Ala Ser Leu Arg Gly Val Val Leu Gly Pro Arg 
1               5                   10                  15      


Gly Ala Gly Leu Pro Gly Ala Arg Ala Arg Gly Leu Leu Cys Ser Ala 
            20                  25                  30          


Arg Pro Gly Gln Leu Pro Leu Arg Thr Pro Gln Ala Val Ala Leu Ser 
        35                  40                  45              


Ser Lys Ser Gly Leu Ser Arg Gly Arg Lys Val Met Leu Ser Ala Leu 
    50                  55                  60                  


Gly Met Leu Ala Ala Gly Gly Ala Gly Leu Ala Val Ala Leu His Ser 
65                  70                  75                  80  


Ala Val Ser Ala Ser Asp Leu Glu Leu His Pro Pro Ser Tyr Pro Trp 
                85                  90                  95      


Ser His Arg Gly Leu Leu Ser Ser Leu Asp His Thr Ser Ile Arg Arg 
            100                 105                 110         


Gly Phe Gln Val Tyr Lys Gln Val Cys Ala Ser Cys His Ser Met Asp 
        115                 120                 125             


Phe Val Ala Tyr Arg His Leu Val Gly Val Cys Tyr Thr Glu Asp Glu 
    130                 135                 140                 


Ala Lys Glu Leu Ala Ala Glu Val Glu Val Gln Asp Gly Pro Asn Glu 
145                 150                 155                 160 


Asp Gly Glu Met Phe Met Arg Pro Gly Lys Leu Phe Asp Tyr Phe Pro 
                165                 170                 175     


Lys Pro Tyr Pro Asn Ser Glu Ala Ala Arg Ala Ala Asn Asn Gly Ala 
            180                 185                 190         


Leu Pro Pro Asp Leu Ser Tyr Ile Val Arg Ala Arg His Gly Gly Glu 
        195                 200                 205             


Asp Tyr Val Phe Ser Leu Leu Thr Gly Tyr Cys Glu Pro Pro Thr Gly 
    210                 215                 220                 


Val Ser Leu Arg Glu Gly Leu Tyr Phe Asn Pro Tyr Phe Pro Gly Gln 
225                 230                 235                 240 


Ala Ile Ala Met Ala Pro Pro Ile Tyr Thr Asp Val Leu Glu Phe Asp 
                245                 250                 255     


Asp Gly Thr Pro Ala Thr Met Ser Gln Ile Ala Lys Asp Val Cys Thr 
            260                 265                 270         


Phe Leu Arg Trp Ala Ser Glu Pro Glu His Asp His Arg Lys Arg Met 
        275                 280                 285             


Gly Leu Lys Met Leu Met Met Met Ala Leu Leu Val Pro Leu Val Tyr 
    290                 295                 300                 


Thr Ile Lys Arg His Lys Trp Ser Val Leu Lys Ser Arg Lys Leu Ala 
305                 310                 315                 320 


Tyr Arg Pro Pro Lys 
                325 


<210>  2790
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYCS__Homo_sapiens__NP_061820

<400>  2790

Met Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser 
1               5                   10                  15      


Gln Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn 
            20                  25                  30          


Leu His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser 
        35                  40                  45              


Tyr Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr 
    50                  55                  60                  


Leu Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys 
65                  70                  75                  80  


Met Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile 
                85                  90                  95      


Ala Tyr Leu Lys Lys Ala Thr Asn Glu 
            100                 105 


<210>  2791
<211>  1253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYFIP1__Homo_sapiens__NP_001274739

<400>  2791

Met Ala Ala Gln Val Thr Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Leu Leu Tyr Gln Pro Asn Phe Asn Thr Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Thr Gly Ile Ala Arg Tyr Ile Glu Gln Ala Thr 
    50                  55                  60                  


Val His Ser Ser Met Asn Glu Met Leu Glu Glu Gly Gln Glu Tyr Ala 
65                  70                  75                  80  


Val Met Leu Tyr Thr Trp Arg Ser Cys Ser Arg Ala Ile Pro Gln Val 
                85                  90                  95      


Lys Cys Asn Glu Gln Pro Asn Arg Val Glu Ile Tyr Glu Lys Thr Val 
            100                 105                 110         


Glu Val Leu Glu Pro Glu Val Thr Lys Leu Met Asn Phe Met Tyr Phe 
        115                 120                 125             


Gln Arg Asn Ala Ile Glu Arg Phe Cys Gly Glu Val Arg Arg Leu Cys 
    130                 135                 140                 


His Ala Glu Arg Arg Lys Asp Phe Val Ser Glu Ala Tyr Leu Ile Thr 
145                 150                 155                 160 


Leu Gly Lys Phe Ile Asn Met Phe Ala Val Leu Asp Glu Leu Lys Asn 
                165                 170                 175     


Met Lys Cys Ser Val Lys Asn Asp His Ser Ala Tyr Lys Arg Ala Ala 
            180                 185                 190         


Gln Phe Leu Arg Lys Met Ala Asp Pro Gln Ser Ile Gln Glu Ser Gln 
        195                 200                 205             


Asn Leu Ser Met Phe Leu Ala Asn His Asn Lys Ile Thr Gln Ser Leu 
    210                 215                 220                 


Gln Gln Gln Leu Glu Val Ile Ser Gly Tyr Glu Glu Leu Leu Ala Asp 
225                 230                 235                 240 


Ile Val Asn Leu Cys Val Asp Tyr Tyr Glu Asn Arg Met Tyr Leu Thr 
                245                 250                 255     


Pro Ser Glu Lys His Met Leu Leu Lys Val Met Gly Phe Gly Leu Tyr 
            260                 265                 270         


Leu Met Asp Gly Ser Val Ser Asn Ile Tyr Lys Leu Asp Ala Lys Lys 
        275                 280                 285             


Arg Ile Asn Leu Ser Lys Ile Asp Lys Tyr Phe Lys Gln Leu Gln Val 
    290                 295                 300                 


Val Pro Leu Phe Gly Asp Met Gln Ile Glu Leu Ala Arg Tyr Ile Lys 
305                 310                 315                 320 


Thr Ser Ala His Tyr Glu Glu Asn Lys Ser Arg Trp Thr Cys Thr Ser 
                325                 330                 335     


Ser Gly Ser Ser Pro Gln Tyr Asn Ile Cys Glu Gln Met Ile Gln Ile 
            340                 345                 350         


Arg Glu Asp His Met Arg Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn 
        355                 360                 365             


Ser Glu Val Val Thr Gly Ser Gly Arg Gln Glu Ala Gln Lys Thr Asp 
    370                 375                 380                 


Ala Glu Tyr Arg Lys Leu Phe Asp Leu Ala Leu Gln Gly Leu Gln Leu 
385                 390                 395                 400 


Leu Ser Gln Trp Ser Ala His Val Met Glu Val Tyr Ser Trp Lys Leu 
                405                 410                 415     


Val His Pro Thr Asp Lys Tyr Ser Asn Lys Asp Cys Pro Asp Ser Ala 
            420                 425                 430         


Glu Glu Tyr Glu Arg Ala Thr Arg Tyr Asn Tyr Thr Ser Glu Glu Lys 
        435                 440                 445             


Phe Ala Leu Val Glu Val Ile Ala Met Ile Lys Gly Leu Gln Val Leu 
    450                 455                 460                 


Met Gly Arg Met Glu Ser Val Phe Asn His Ala Ile Arg His Thr Val 
465                 470                 475                 480 


Tyr Ala Ala Leu Gln Asp Phe Ser Gln Val Thr Leu Arg Glu Pro Leu 
                485                 490                 495     


Arg Gln Ala Ile Lys Lys Lys Lys Asn Val Ile Gln Ser Val Leu Gln 
            500                 505                 510         


Ala Ile Arg Lys Thr Val Cys Asp Trp Glu Thr Gly His Glu Pro Phe 
        515                 520                 525             


Asn Asp Pro Ala Leu Arg Gly Glu Lys Asp Pro Lys Ser Gly Phe Asp 
    530                 535                 540                 


Ile Lys Val Pro Arg Arg Ala Val Gly Pro Ser Ser Thr Gln Leu Tyr 
545                 550                 555                 560 


Met Val Arg Thr Met Leu Glu Ser Leu Ile Ala Asp Lys Ser Gly Ser 
                565                 570                 575     


Lys Lys Thr Leu Arg Ser Ser Leu Glu Gly Pro Thr Ile Leu Asp Ile 
            580                 585                 590         


Glu Lys Phe His Arg Glu Ser Phe Phe Tyr Thr His Leu Ile Asn Phe 
        595                 600                 605             


Ser Glu Thr Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp Phe Arg 
    610                 615                 620                 


Glu Phe Phe Leu Glu Leu Thr Met Gly Arg Arg Ile Gln Phe Pro Ile 
625                 630                 635                 640 


Glu Met Ser Met Pro Trp Ile Leu Thr Asp His Ile Leu Glu Thr Lys 
                645                 650                 655     


Glu Ala Ser Met Met Glu Tyr Val Leu Tyr Ser Leu Asp Leu Tyr Asn 
            660                 665                 670         


Asp Ser Ala His Tyr Ala Leu Thr Arg Phe Asn Lys Gln Phe Leu Tyr 
        675                 680                 685             


Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe Val Tyr 
    690                 695                 700                 


Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Val Met Ala Gly Ser 
705                 710                 715                 720 


Leu Leu Leu Asp Lys Arg Leu Arg Ser Glu Cys Lys Asn Gln Gly Ala 
                725                 730                 735     


Thr Ile His Leu Pro Pro Ser Asn Arg Tyr Glu Thr Leu Leu Lys Gln 
            740                 745                 750         


Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg Leu Ile 
        755                 760                 765             


Thr Gln Arg Val Ser Ala Ala Met Tyr Lys Ser Leu Glu Leu Ala Ile 
    770                 775                 780                 


Gly Arg Phe Glu Ser Glu Asp Leu Thr Ser Ile Val Glu Leu Asp Gly 
785                 790                 795                 800 


Leu Leu Glu Ile Asn Arg Met Thr His Lys Leu Leu Ser Arg Tyr Leu 
                805                 810                 815     


Thr Leu Asp Gly Phe Asp Ala Met Phe Arg Glu Ala Asn His Asn Val 
            820                 825                 830         


Ser Ala Pro Tyr Gly Arg Ile Thr Leu His Val Phe Trp Glu Leu Asn 
        835                 840                 845             


Tyr Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Thr Asn Arg Phe 
    850                 855                 860                 


Val Arg Thr Val Leu Pro Phe Ser Gln Glu Phe Gln Arg Asp Lys Gln 
865                 870                 875                 880 


Pro Asn Ala Gln Pro Gln Tyr Leu His Gly Ser Lys Ala Leu Asn Leu 
                885                 890                 895     


Ala Tyr Ser Ser Ile Tyr Gly Ser Tyr Arg Asn Phe Val Gly Pro Pro 
            900                 905                 910         


His Phe Gln Val Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile Ala Val 
        915                 920                 925             


Val Met Glu Glu Leu Leu Lys Val Val Lys Ser Leu Leu Gln Gly Thr 
    930                 935                 940                 


Ile Leu Gln Tyr Val Lys Thr Leu Met Glu Val Met Pro Lys Ile Cys 
945                 950                 955                 960 


Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu Phe Phe 
                965                 970                 975     


His His Gln Leu Lys Asp Ile Val Glu Tyr Ala Glu Leu Lys Thr Val 
            980                 985                 990         


Cys Phe Gln Asn Leu Arg Glu Val  Gly Asn Ala Ile Leu  Phe Cys Leu 
        995                 1000                 1005             


Leu Ile  Glu Gln Ser Leu Ser  Leu Glu Glu Val Cys  Asp Leu Leu 
    1010                 1015                 1020             


His Ala  Ala Pro Phe Gln Asn  Ile Leu Pro Arg Val  His Val Lys 
    1025                 1030                 1035             


Glu Gly  Glu Arg Leu Asp Ala  Lys Met Lys Arg Leu  Glu Ser Lys 
    1040                 1045                 1050             


Tyr Ala  Pro Leu His Leu Val  Pro Leu Ile Glu Arg  Leu Gly Thr 
    1055                 1060                 1065             


Pro Gln  Gln Ile Ala Ile Ala  Arg Glu Gly Asp Leu  Leu Thr Lys 
    1070                 1075                 1080             


Glu Arg  Leu Cys Cys Gly Leu  Ser Met Phe Glu Val  Ile Leu Thr 
    1085                 1090                 1095             


Arg Ile  Arg Ser Phe Leu Asp  Asp Pro Ile Trp Arg  Gly Pro Leu 
    1100                 1105                 1110             


Pro Ser  Asn Gly Val Met His  Val Asp Glu Cys Val  Glu Phe His 
    1115                 1120                 1125             


Arg Leu  Trp Ser Ala Met Gln  Phe Val Tyr Cys Ile  Pro Val Gly 
    1130                 1135                 1140             


Thr His  Glu Phe Thr Val Glu  Gln Cys Phe Gly Asp  Gly Leu His 
    1145                 1150                 1155             


Trp Ala  Gly Cys Met Ile Ile  Val Leu Leu Gly Gln  Gln Arg Arg 
    1160                 1165                 1170             


Phe Ala  Val Leu Asp Phe Cys  Tyr His Leu Leu Lys  Val Gln Lys 
    1175                 1180                 1185             


His Asp  Gly Lys Asp Glu Ile  Ile Lys Asn Val Pro  Leu Lys Lys 
    1190                 1195                 1200             


Met Val  Glu Arg Ile Arg Lys  Phe Gln Ile Leu Asn  Asp Glu Ile 
    1205                 1210                 1215             


Ile Thr  Ile Leu Asp Lys Tyr  Leu Lys Ser Gly Asp  Gly Glu Gly 
    1220                 1225                 1230             


Thr Pro  Val Glu His Val Arg  Cys Phe Gln Pro Pro  Ile His Gln 
    1235                 1240                 1245             


Ser Leu  Ala Ser Ser 
    1250             


<210>  2792
<211>  1227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYFIP2__Homo_sapiens__NP_001278650

<400>  2792

Met Thr Thr His Val Thr Leu Glu Asp Ala Leu Ser Asn Val Asp Leu 
1               5                   10                  15      


Leu Glu Glu Leu Pro Leu Pro Asp Gln Gln Pro Cys Ile Glu Pro Pro 
            20                  25                  30          


Pro Ser Ser Ile Met Tyr Gln Ala Asn Phe Asp Thr Asn Phe Glu Asp 
        35                  40                  45              


Arg Asn Ala Phe Val Thr Gly Ile Ala Arg Tyr Ile Glu Gln Ala Thr 
    50                  55                  60                  


Val His Ser Ser Met Val Lys Cys Asn Glu Gln Pro Asn Arg Val Glu 
65                  70                  75                  80  


Ile Tyr Glu Lys Thr Val Glu Val Leu Glu Pro Glu Val Thr Lys Leu 
                85                  90                  95      


Met Lys Phe Met Tyr Phe Gln Arg Lys Ala Ile Glu Arg Phe Cys Ser 
            100                 105                 110         


Glu Val Lys Arg Leu Cys His Ala Glu Arg Arg Lys Asp Phe Val Ser 
        115                 120                 125             


Glu Ala Tyr Leu Leu Thr Leu Gly Lys Phe Ile Asn Met Phe Ala Val 
    130                 135                 140                 


Leu Asp Glu Leu Lys Asn Met Lys Cys Ser Val Lys Asn Asp His Ser 
145                 150                 155                 160 


Ala Tyr Lys Arg Ala Ala Gln Phe Leu Arg Lys Met Ala Asp Pro Gln 
                165                 170                 175     


Ser Ile Gln Glu Ser Gln Asn Leu Ser Met Phe Leu Ala Asn His Asn 
            180                 185                 190         


Arg Ile Thr Gln Cys Leu His Gln Gln Leu Glu Val Ile Pro Gly Tyr 
        195                 200                 205             


Glu Glu Leu Leu Ala Asp Ile Val Asn Ile Cys Val Asp Tyr Tyr Glu 
    210                 215                 220                 


Asn Lys Met Tyr Leu Thr Pro Ser Glu Lys His Met Leu Leu Lys Val 
225                 230                 235                 240 


Met Gly Phe Gly Leu Tyr Leu Met Asp Gly Asn Val Ser Asn Ile Tyr 
                245                 250                 255     


Lys Leu Asp Ala Lys Lys Arg Ile Asn Leu Ser Lys Ile Asp Lys Phe 
            260                 265                 270         


Phe Lys Gln Leu Gln Val Val Pro Leu Phe Gly Asp Met Gln Ile Glu 
        275                 280                 285             


Leu Ala Arg Tyr Ile Lys Thr Ser Ala His Tyr Glu Glu Asn Lys Ser 
    290                 295                 300                 


Lys Trp Thr Cys Thr Gln Ser Ser Ile Ser Pro Gln Tyr Asn Ile Cys 
305                 310                 315                 320 


Glu Gln Met Val Gln Ile Arg Asp Asp His Ile Arg Phe Ile Ser Glu 
                325                 330                 335     


Leu Ala Arg Tyr Ser Asn Ser Glu Val Val Thr Gly Ser Gly Leu Asp 
            340                 345                 350         


Ser Gln Lys Ser Asp Glu Glu Tyr Arg Glu Leu Phe Asp Leu Ala Leu 
        355                 360                 365             


Arg Gly Leu Gln Leu Leu Ser Lys Trp Ser Ala His Val Met Glu Val 
    370                 375                 380                 


Tyr Ser Trp Lys Leu Val His Pro Thr Asp Lys Phe Cys Asn Lys Asp 
385                 390                 395                 400 


Cys Pro Gly Thr Ala Glu Glu Tyr Glu Arg Ala Thr Arg Tyr Asn Tyr 
                405                 410                 415     


Thr Ser Glu Glu Lys Phe Ala Phe Val Glu Val Ile Ala Met Ile Lys 
            420                 425                 430         


Gly Leu Gln Val Leu Met Gly Arg Met Glu Ser Val Phe Asn Gln Ala 
        435                 440                 445             


Ile Arg Asn Thr Ile Tyr Ala Ala Leu Gln Asp Phe Ala Gln Val Thr 
    450                 455                 460                 


Leu Arg Glu Pro Leu Arg Gln Ala Val Arg Lys Lys Lys Asn Val Leu 
465                 470                 475                 480 


Ile Ser Val Leu Gln Ala Ile Arg Lys Thr Ile Cys Asp Trp Glu Gly 
                485                 490                 495     


Gly Arg Glu Pro Pro Asn Asp Pro Cys Leu Arg Gly Glu Lys Asp Pro 
            500                 505                 510         


Lys Gly Gly Phe Asp Ile Lys Val Pro Arg Arg Ala Val Gly Pro Ser 
        515                 520                 525             


Ser Thr Gln Leu Tyr Met Val Arg Thr Met Leu Glu Ser Leu Ile Ala 
    530                 535                 540                 


Asp Lys Ser Gly Ser Lys Lys Thr Leu Arg Ser Ser Leu Asp Gly Pro 
545                 550                 555                 560 


Ile Val Leu Ala Ile Glu Asp Phe His Lys Gln Ser Phe Phe Phe Thr 
                565                 570                 575     


His Leu Leu Asn Ile Ser Glu Ala Leu Gln Gln Cys Cys Asp Leu Ser 
            580                 585                 590         


Gln Leu Trp Phe Arg Glu Phe Phe Leu Glu Leu Thr Met Gly Arg Arg 
        595                 600                 605             


Ile Gln Phe Pro Ile Glu Met Ser Met Pro Trp Ile Leu Thr Asp His 
    610                 615                 620                 


Ile Leu Glu Thr Lys Glu Pro Ser Met Met Glu Tyr Val Leu Tyr Pro 
625                 630                 635                 640 


Leu Asp Leu Tyr Asn Asp Ser Ala Tyr Tyr Ala Leu Thr Lys Phe Lys 
                645                 650                 655     


Lys Gln Phe Leu Tyr Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe 
            660                 665                 670         


Asp Gln Phe Val Tyr Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys 
        675                 680                 685             


Ala Met Ala Gly Ser Val Leu Leu Asp Lys Arg Phe Arg Ala Glu Cys 
    690                 695                 700                 


Lys Asn Tyr Gly Val Ile Ile Pro Tyr Pro Pro Ser Asn Arg Tyr Glu 
705                 710                 715                 720 


Thr Leu Leu Lys Gln Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp 
                725                 730                 735     


Leu Asn Arg Leu Ile Thr Gln Arg Ile Ser Ala Ala Met Tyr Lys Ser 
            740                 745                 750         


Leu Asp Gln Ala Ile Ser Arg Phe Glu Ser Glu Asp Leu Thr Ser Ile 
        755                 760                 765             


Val Glu Leu Glu Trp Leu Leu Glu Ile Asn Arg Leu Thr His Arg Leu 
    770                 775                 780                 


Leu Cys Lys His Met Thr Leu Asp Ser Phe Asp Ala Met Phe Arg Glu 
785                 790                 795                 800 


Ala Asn His Asn Val Ser Ala Pro Tyr Gly Arg Ile Thr Leu His Val 
                805                 810                 815     


Phe Trp Glu Leu Asn Phe Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly 
            820                 825                 830         


Ser Thr Asn Arg Phe Val Arg Thr Ala Ile Pro Phe Thr Gln Glu Pro 
        835                 840                 845             


Gln Arg Asp Lys Pro Ala Asn Val Gln Pro Tyr Tyr Leu Tyr Gly Ser 
    850                 855                 860                 


Lys Pro Leu Asn Ile Ala Tyr Ser His Ile Tyr Ser Ser Tyr Arg Asn 
865                 870                 875                 880 


Phe Val Gly Pro Pro His Phe Lys Thr Ile Cys Arg Leu Leu Gly Tyr 
                885                 890                 895     


Gln Gly Ile Ala Val Val Met Glu Glu Leu Leu Lys Ile Val Lys Ser 
            900                 905                 910         


Leu Leu Gln Gly Thr Ile Leu Gln Tyr Val Lys Thr Leu Ile Glu Val 
        915                 920                 925             


Met Pro Lys Ile Cys Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly 
    930                 935                 940                 


Ile Leu Glu Phe Phe His His Gln Leu Lys Asp Ile Ile Glu Tyr Ala 
945                 950                 955                 960 


Glu Leu Lys Thr Asp Val Phe Gln Ser Leu Arg Glu Val Gly Asn Ala 
                965                 970                 975     


Ile Leu Phe Cys Leu Leu Ile Glu Gln Ala Leu Ser Gln Glu Glu Val 
            980                 985                 990         


Cys Asp Leu Leu His Ala Ala Pro  Phe Gln Asn Ile Leu  Pro Arg Val 
        995                 1000                 1005             


Tyr Ile  Lys Glu Gly Glu Arg  Leu Glu Val Arg Met  Lys Arg Leu 
    1010                 1015                 1020             


Glu Ala  Lys Tyr Ala Pro Leu  His Leu Val Pro Leu  Ile Glu Arg 
    1025                 1030                 1035             


Leu Gly  Thr Pro Gln Gln Ile  Ala Ile Ala Arg Glu  Gly Asp Leu 
    1040                 1045                 1050             


Leu Thr  Lys Glu Arg Leu Cys  Cys Gly Leu Ser Met  Phe Glu Val 
    1055                 1060                 1065             


Ile Leu  Thr Arg Ile Arg Ser  Tyr Leu Gln Asp Pro  Ile Trp Arg 
    1070                 1075                 1080             


Gly Pro  Pro Pro Thr Asn Gly  Val Met His Val Asp  Glu Cys Val 
    1085                 1090                 1095             


Glu Phe  His Arg Leu Trp Ser  Ala Met Gln Phe Val  Tyr Cys Ile 
    1100                 1105                 1110             


Pro Val  Gly Thr Asn Glu Phe  Thr Ala Glu Gln Cys  Phe Gly Asp 
    1115                 1120                 1125             


Gly Leu  Asn Trp Ala Gly Cys  Ser Ile Ile Val Leu  Leu Gly Gln 
    1130                 1135                 1140             


Gln Arg  Arg Phe Asp Leu Phe  Asp Phe Cys Tyr His  Leu Leu Lys 
    1145                 1150                 1155             


Val Gln  Arg Gln Asp Gly Lys  Asp Glu Ile Ile Lys  Asn Val Pro 
    1160                 1165                 1170             


Leu Lys  Lys Met Ala Asp Arg  Ile Arg Lys Tyr Gln  Ile Leu Asn 
    1175                 1180                 1185             


Asn Glu  Val Phe Ala Ile Leu  Asn Lys Tyr Met Lys  Ser Val Glu 
    1190                 1195                 1200             


Thr Asp  Ser Ser Thr Val Glu  His Val Arg Cys Phe  Gln Pro Pro 
    1205                 1210                 1215             


Ile His  Gln Ser Leu Ala Thr  Thr Cys 
    1220                 1225         


<210>  2793
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYGB__Homo_sapiens__NP_599030

<400>  2793

Met Glu Lys Val Pro Gly Glu Met Glu Ile Glu Arg Arg Glu Arg Ser 
1               5                   10                  15      


Glu Glu Leu Ser Glu Ala Glu Arg Lys Ala Val Gln Ala Met Trp Ala 
            20                  25                  30          


Arg Leu Tyr Ala Asn Cys Glu Asp Val Gly Val Ala Ile Leu Val Arg 
        35                  40                  45              


Phe Phe Val Asn Phe Pro Ser Ala Lys Gln Tyr Phe Ser Gln Phe Lys 
    50                  55                  60                  


His Met Glu Asp Pro Leu Glu Met Glu Arg Ser Pro Gln Leu Arg Lys 
65                  70                  75                  80  


His Ala Cys Arg Val Met Gly Ala Leu Asn Thr Val Val Glu Asn Leu 
                85                  90                  95      


His Asp Pro Asp Lys Val Ser Ser Val Leu Ala Leu Val Gly Lys Ala 
            100                 105                 110         


His Ala Leu Lys His Lys Val Glu Pro Val Tyr Phe Lys Ile Leu Ser 
        115                 120                 125             


Gly Val Ile Leu Glu Val Val Ala Glu Glu Phe Ala Ser Asp Phe Pro 
    130                 135                 140                 


Pro Glu Thr Gln Arg Ala Trp Ala Lys Leu Arg Gly Leu Ile Tyr Ser 
145                 150                 155                 160 


His Val Thr Ala Ala Tyr Lys Glu Val Gly Trp Val Gln Gln Val Pro 
                165                 170                 175     


Asn Ala Thr Thr Pro Pro Ala Thr Leu Pro Ser Ser Gly Pro 
            180                 185                 190 


<210>  2794
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYLC1__Homo_sapiens__NP_066941

<400>  2794

Met Ser Leu Pro Arg Leu Leu Lys Val Asn Ile Arg Thr Tyr Asp Asn 
1               5                   10                  15      


Ser Ile Pro Ile Ser Glu Ser Ser Arg Lys Ser Trp Asn Gln Lys His 
            20                  25                  30          


Phe Ala Leu Thr Phe Pro Lys Pro Leu Gln Arg Gly Thr Asn Asp Lys 
        35                  40                  45              


Ser Arg Pro Leu Lys Ser Gln Ile Thr Val Thr Arg His Asp Lys Arg 
    50                  55                  60                  


Lys Leu Glu Glu Gly Gln Lys Pro Ala His Lys Trp Ile Arg His Ser 
65                  70                  75                  80  


Phe Arg Lys Ile Leu Gln Trp Pro Pro Ile Tyr Thr Ala Ala Arg Glu 
                85                  90                  95      


Gln Thr Pro Phe Arg His Leu Tyr Thr Ser Lys Thr His Leu Lys Lys 
            100                 105                 110         


Ala Glu Tyr Lys Lys Ser Lys Asp Glu Lys Gly Gly Thr Pro Leu Lys 
        115                 120                 125             


Lys Asp Ser Lys Lys Lys Gly Gly Ser Tyr Ala Thr Asn Pro Glu Ser 
    130                 135                 140                 


Lys Gln Ile Val Glu Glu Lys Thr Lys Arg Gln Asn Glu Ala Asp Lys 
145                 150                 155                 160 


Thr Pro Leu Lys Ser Ser His Glu Asn Glu Gln Ser Lys Lys Ser Lys 
                165                 170                 175     


Ser Ser Ser Glu Thr Asn Pro Glu Ser Gln Asn Ser Lys Thr Val Ser 
            180                 185                 190         


Lys Asn Cys Ser Gln Lys Asp Lys Lys Asp Ser Lys Asn Ser Lys Lys 
        195                 200                 205             


Thr Asn Thr Glu Phe Leu His Thr Lys Asn Asn Pro Lys Lys Asp Leu 
    210                 215                 220                 


Lys Arg Ser Lys Thr Ser Asn Asp Pro Ile Ser Glu Ile Cys Ser Glu 
225                 230                 235                 240 


Asn Ser Leu Asn Val Asp Phe Leu Met Leu Val Gly Gln Ser Asp Asp 
                245                 250                 255     


Glu Ser Ile Asn Phe Asp Ala Trp Leu Arg Asn Tyr Ser Gln Asn Asn 
            260                 265                 270         


Ser Lys Asn Tyr Ser Leu Lys Tyr Thr Lys Tyr Thr Lys Lys Asp Thr 
        275                 280                 285             


Lys Lys Asn Ala Lys Lys Ser Ser Asp Ala Glu Ser Glu Asp Ser Lys 
    290                 295                 300                 


Asp Ala Lys Lys Asp Ser Lys Lys Val Lys Lys Asn Val Lys Lys Asp 
305                 310                 315                 320 


Asp Lys Lys Lys Asp Val Lys Lys Asp Thr Glu Ser Thr Asp Ala Glu 
                325                 330                 335     


Ser Gly Asp Ser Lys Asp Glu Arg Lys Asp Thr Lys Lys Asp Lys Lys 
            340                 345                 350         


Lys Leu Lys Lys Asp Asp Lys Lys Lys Asp Thr Lys Lys Tyr Pro Glu 
        355                 360                 365             


Ser Thr Asp Thr Glu Ser Gly Asp Ala Lys Asp Ala Arg Asn Asp Ser 
    370                 375                 380                 


Arg Asn Leu Lys Lys Ala Ser Lys Asn Asp Asp Lys Lys Lys Asp Ala 
385                 390                 395                 400 


Lys Lys Ile Thr Phe Ser Thr Asp Ser Glu Ser Glu Leu Glu Ser Lys 
                405                 410                 415     


Glu Ser Gln Lys Asp Glu Lys Lys Asp Lys Lys Asp Ser Lys Thr Asp 
            420                 425                 430         


Asn Lys Lys Ser Val Lys Asn Asp Glu Glu Ser Thr Asp Ala Asp Ser 
        435                 440                 445             


Glu Pro Lys Gly Asp Ser Lys Lys Gly Lys Lys Asp Glu Lys Lys Gly 
    450                 455                 460                 


Lys Lys Asp Ser Lys Lys Asp Asp Lys Lys Lys Asp Ala Lys Lys Asn 
465                 470                 475                 480 


Ala Glu Ser Thr Glu Met Glu Ser Asp Leu Glu Leu Lys Lys Asp Lys 
                485                 490                 495     


Lys His Ser Lys Glu Lys Lys Gly Ser Lys Lys Asp Ile Lys Lys Asp 
            500                 505                 510         


Ala Arg Lys Asp Thr Glu Ser Thr Asp Ala Glu Phe Asp Glu Ser Ser 
        515                 520                 525             


Lys Thr Gly Phe Lys Thr Ser Thr Lys Ile Lys Gly Ser Asp Thr Glu 
    530                 535                 540                 


Ser Glu Glu Ser Leu Tyr Lys Pro Gly Ala Lys Lys Lys Ile Asp Glu 
545                 550                 555                 560 


Ser Asp Gly Thr Ser Ala Asn Ser Lys Met Glu Gly Leu Glu Ser Lys 
                565                 570                 575     


Arg Gly Phe Arg Met Ser Ser Lys Lys Thr Thr Phe Asn Glu Lys Gly 
            580                 585                 590         


Glu Lys Ala Ser Thr Gly Arg Val Pro Pro Ser Arg Glu Lys Pro Pro 
        595                 600                 605             


Leu Pro Ala Cys Glu Pro Ser Leu Pro Ser Pro Lys Val Arg Arg Leu 
    610                 615                 620                 


Cys Trp Cys Lys Met Pro Pro Pro Pro Pro Lys Pro Arg Tyr Ala Pro 
625                 630                 635                 640 


Leu Pro Glu Ala Pro Trp Ile His Lys Leu Leu 
                645                 650     


<210>  2795
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYLC2__Homo_sapiens__NP_001331

<400>  2795

Met Ser Leu Pro Arg Phe Gln Arg Val Asn Phe Gly Pro Tyr Asp Asn 
1               5                   10                  15      


Tyr Ile Pro Val Ser Glu Leu Ser Lys Lys Ser Trp Asn Gln Gln His 
            20                  25                  30          


Phe Ala Leu Leu Phe Pro Lys Pro Gln Arg Pro Gly Thr Lys Arg Arg 
        35                  40                  45              


Ser Lys Pro Ser Gln Ile Arg Asp Asn Thr Val Ser Ile Ile Asp Glu 
    50                  55                  60                  


Glu Gln Leu Arg Gly Asp Arg Arg Gln Pro Leu Trp Met Tyr Arg Ser 
65                  70                  75                  80  


Leu Met Arg Ile Ser Glu Arg Pro Ser Val Tyr Leu Ala Ala Arg Arg 
                85                  90                  95      


Gln Pro Leu Lys Pro Thr Arg Thr Val Glu Val Asp Ser Lys Ala Ala 
            100                 105                 110         


Glu Ile Gly Lys Lys Gly Glu Asp Lys Thr Thr Gln Lys Asp Thr Thr 
        115                 120                 125             


Asp Ser Glu Ser Glu Leu Lys Gln Gly Lys Lys Asp Ser Lys Lys Gly 
    130                 135                 140                 


Lys Asp Ile Glu Lys Gly Lys Glu Glu Lys Leu Asp Ala Lys Lys Asp 
145                 150                 155                 160 


Ser Lys Lys Gly Lys Lys Asp Ala Glu Lys Gly Lys Asp Ser Ala Thr 
                165                 170                 175     


Glu Ser Glu Asp Glu Lys Gly Gly Ala Lys Lys Asp Asn Lys Lys Asp 
            180                 185                 190         


Lys Lys Asp Ser Asn Lys Gly Lys Asp Ser Ala Thr Glu Ser Glu Gly 
        195                 200                 205             


Glu Lys Gly Gly Thr Glu Lys Asp Ser Lys Lys Gly Lys Lys Asp Ser 
    210                 215                 220                 


Lys Lys Gly Lys Asp Ser Ala Ile Glu Leu Gln Ala Val Lys Ala Asp 
225                 230                 235                 240 


Glu Lys Lys Asp Glu Asp Gly Lys Lys Asp Ala Asn Lys Gly Asp Glu 
                245                 250                 255     


Ser Lys Asp Ala Lys Lys Asp Ala Lys Glu Ile Lys Lys Gly Lys Lys 
            260                 265                 270         


Asp Lys Lys Lys Pro Ser Ser Thr Asp Ser Asp Ser Lys Asp Asp Val 
        275                 280                 285             


Lys Lys Glu Ser Lys Lys Asp Ala Thr Lys Asp Ala Lys Lys Val Ala 
    290                 295                 300                 


Lys Lys Asp Thr Glu Lys Glu Ser Ala Asp Ser Lys Lys Asp Ala Lys 
305                 310                 315                 320 


Lys Asn Ala Lys Lys Asp Ala Lys Lys Asp Ala Lys Lys Asn Ala Lys 
                325                 330                 335     


Lys Asp Glu Lys Lys Asp Ala Lys Lys Lys Gly Lys 
            340                 345             


<210>  2796
<211>  953
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYLD__Homo_sapiens__NP_001035877

<400>  2796

Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser 
    370                 375                 380                 


Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro Pro Leu Gln 
385                 390                 395                 400 


Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe His Ser Leu 
                405                 410                 415     


Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser Ile Gly His 
            420                 425                 430         


Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu Leu Asn Thr 
        435                 440                 445             


Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro Gly Asn Ser 
    450                 455                 460                 


His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro 
465                 470                 475                 480 


Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Thr Asp 
            500                 505                 510         


Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu Lys Lys Ala 
        515                 520                 525             


Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser 
    530                 535                 540                 


Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe 
545                 550                 555                 560 


Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro Pro Lys Met 
                565                 570                 575     


Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln 
            580                 585                 590         


Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe 
        595                 600                 605             


Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys 
    610                 615                 620                 


Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu 
625                 630                 635                 640 


Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile 
                645                 650                 655     


Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe 
            660                 665                 670         


Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His 
        675                 680                 685             


His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln 
    690                 695                 700                 


Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu 
705                 710                 715                 720 


Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile 
                725                 730                 735     


Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln 
            740                 745                 750         


Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro 
        755                 760                 765             


Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln 
    770                 775                 780                 


Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr 
785                 790                 795                 800 


Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr 
                805                 810                 815     


Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr 
            820                 825                 830         


Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His 
        835                 840                 845             


Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile 
    850                 855                 860                 


Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser 
865                 870                 875                 880 


Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn 
                885                 890                 895     


Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr 
            900                 905                 910         


Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile 
        915                 920                 925             


Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr 
    930                 935                 940                 


Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950             


<210>  2797
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP11A1__Homo_sapiens__NP_000772

<400>  2797

Met Leu Ala Lys Gly Leu Pro Pro Arg Ser Val Leu Val Lys Gly Cys 
1               5                   10                  15      


Gln Thr Phe Leu Ser Ala Pro Arg Glu Gly Leu Gly Arg Leu Arg Val 
            20                  25                  30          


Pro Thr Gly Glu Gly Ala Gly Ile Ser Thr Arg Ser Pro Arg Pro Phe 
        35                  40                  45              


Asn Glu Ile Pro Ser Pro Gly Asp Asn Gly Trp Leu Asn Leu Tyr His 
    50                  55                  60                  


Phe Trp Arg Glu Thr Gly Thr His Lys Val His Leu His His Val Gln 
65                  70                  75                  80  


Asn Phe Gln Lys Tyr Gly Pro Ile Tyr Arg Glu Lys Leu Gly Asn Val 
                85                  90                  95      


Glu Ser Val Tyr Val Ile Asp Pro Glu Asp Val Ala Leu Leu Phe Lys 
            100                 105                 110         


Ser Glu Gly Pro Asn Pro Glu Arg Phe Leu Ile Pro Pro Trp Val Ala 
        115                 120                 125             


Tyr His Gln Tyr Tyr Gln Arg Pro Ile Gly Val Leu Leu Lys Lys Ser 
    130                 135                 140                 


Ala Ala Trp Lys Lys Asp Arg Val Ala Leu Asn Gln Glu Val Met Ala 
145                 150                 155                 160 


Pro Glu Ala Thr Lys Asn Phe Leu Pro Leu Leu Asp Ala Val Ser Arg 
                165                 170                 175     


Asp Phe Val Ser Val Leu His Arg Arg Ile Lys Lys Ala Gly Ser Gly 
            180                 185                 190         


Asn Tyr Ser Gly Asp Ile Ser Asp Asp Leu Phe Arg Phe Ala Phe Glu 
        195                 200                 205             


Ser Ile Thr Asn Val Ile Phe Gly Glu Arg Gln Gly Met Leu Glu Glu 
    210                 215                 220                 


Val Val Asn Pro Glu Ala Gln Arg Phe Ile Asp Ala Ile Tyr Gln Met 
225                 230                 235                 240 


Phe His Thr Ser Val Pro Met Leu Asn Leu Pro Pro Asp Leu Phe Arg 
                245                 250                 255     


Leu Phe Arg Thr Lys Thr Trp Lys Asp His Val Ala Ala Trp Asp Val 
            260                 265                 270         


Ile Phe Ser Lys Ala Asp Ile Tyr Thr Gln Asn Phe Tyr Trp Glu Leu 
        275                 280                 285             


Arg Gln Lys Gly Ser Val His His Asp Tyr Arg Gly Ile Leu Tyr Arg 
    290                 295                 300                 


Leu Leu Gly Asp Ser Lys Met Ser Phe Glu Asp Ile Lys Ala Asn Val 
305                 310                 315                 320 


Thr Glu Met Leu Ala Gly Gly Val Asp Thr Thr Ser Met Thr Leu Gln 
                325                 330                 335     


Trp His Leu Tyr Glu Met Ala Arg Asn Leu Lys Val Gln Asp Met Leu 
            340                 345                 350         


Arg Ala Glu Val Leu Ala Ala Arg His Gln Ala Gln Gly Asp Met Ala 
        355                 360                 365             


Thr Met Leu Gln Leu Val Pro Leu Leu Lys Ala Ser Ile Lys Glu Thr 
    370                 375                 380                 


Leu Arg Leu His Pro Ile Ser Val Thr Leu Gln Arg Tyr Leu Val Asn 
385                 390                 395                 400 


Asp Leu Val Leu Arg Asp Tyr Met Ile Pro Ala Lys Thr Leu Val Gln 
                405                 410                 415     


Val Ala Ile Tyr Ala Leu Gly Arg Glu Pro Thr Phe Phe Phe Asp Pro 
            420                 425                 430         


Glu Asn Phe Asp Pro Thr Arg Trp Leu Ser Lys Asp Lys Asn Ile Thr 
        435                 440                 445             


Tyr Phe Arg Asn Leu Gly Phe Gly Trp Gly Val Arg Gln Cys Leu Gly 
    450                 455                 460                 


Arg Arg Ile Ala Glu Leu Glu Met Thr Ile Phe Leu Ile Asn Met Leu 
465                 470                 475                 480 


Glu Asn Phe Arg Val Glu Ile Gln His Leu Ser Asp Val Gly Thr Thr 
                485                 490                 495     


Phe Asn Leu Ile Leu Met Pro Glu Lys Pro Ile Ser Phe Thr Phe Trp 
            500                 505                 510         


Pro Phe Asn Gln Glu Ala Thr Gln Gln 
        515                 520     


<210>  2798
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP11B1__Homo_sapiens__NP_000488

<400>  2798

Met Ala Leu Arg Ala Lys Ala Glu Val Cys Met Ala Val Pro Trp Leu 
1               5                   10                  15      


Ser Leu Gln Arg Ala Gln Ala Leu Gly Thr Arg Ala Ala Arg Val Pro 
            20                  25                  30          


Arg Thr Val Leu Pro Phe Glu Ala Met Pro Arg Arg Pro Gly Asn Arg 
        35                  40                  45              


Trp Leu Arg Leu Leu Gln Ile Trp Arg Glu Gln Gly Tyr Glu Asp Leu 
    50                  55                  60                  


His Leu Glu Val His Gln Thr Phe Gln Glu Leu Gly Pro Ile Phe Arg 
65                  70                  75                  80  


Tyr Asp Leu Gly Gly Ala Gly Met Val Cys Val Met Leu Pro Glu Asp 
                85                  90                  95      


Val Glu Lys Leu Gln Gln Val Asp Ser Leu His Pro His Arg Met Ser 
            100                 105                 110         


Leu Glu Pro Trp Val Ala Tyr Arg Gln His Arg Gly His Lys Cys Gly 
        115                 120                 125             


Val Phe Leu Leu Asn Gly Pro Glu Trp Arg Phe Asn Arg Leu Arg Leu 
    130                 135                 140                 


Asn Pro Glu Val Leu Ser Pro Asn Ala Val Gln Arg Phe Leu Pro Met 
145                 150                 155                 160 


Val Asp Ala Val Ala Arg Asp Phe Ser Gln Ala Leu Lys Lys Lys Val 
                165                 170                 175     


Leu Gln Asn Ala Arg Gly Ser Leu Thr Leu Asp Val Gln Pro Ser Ile 
            180                 185                 190         


Phe His Tyr Thr Ile Glu Ala Ser Asn Leu Ala Leu Phe Gly Glu Arg 
        195                 200                 205             


Leu Gly Leu Val Gly His Ser Pro Ser Ser Ala Ser Leu Asn Phe Leu 
    210                 215                 220                 


His Ala Leu Glu Val Met Phe Lys Ser Thr Val Gln Leu Met Phe Met 
225                 230                 235                 240 


Pro Arg Ser Leu Ser Arg Trp Thr Ser Pro Lys Val Trp Lys Glu His 
                245                 250                 255     


Phe Glu Ala Trp Asp Cys Ile Phe Gln Tyr Gly Asp Asn Cys Ile Gln 
            260                 265                 270         


Lys Ile Tyr Gln Glu Leu Ala Phe Ser Arg Pro Gln Gln Tyr Thr Ser 
        275                 280                 285             


Ile Val Ala Glu Leu Leu Leu Asn Ala Glu Leu Ser Pro Asp Ala Ile 
    290                 295                 300                 


Lys Ala Asn Ser Met Glu Leu Thr Ala Gly Ser Val Asp Thr Thr Val 
305                 310                 315                 320 


Phe Pro Leu Leu Met Thr Leu Phe Glu Leu Ala Arg Asn Pro Asn Val 
                325                 330                 335     


Gln Gln Ala Leu Arg Gln Glu Ser Leu Ala Ala Ala Ala Ser Ile Ser 
            340                 345                 350         


Glu His Pro Gln Lys Ala Thr Thr Glu Leu Pro Leu Leu Arg Ala Ala 
        355                 360                 365             


Leu Lys Glu Thr Leu Arg Leu Tyr Pro Val Gly Leu Phe Leu Glu Arg 
    370                 375                 380                 


Val Ala Ser Ser Asp Leu Val Leu Gln Asn Tyr His Ile Pro Ala Gly 
385                 390                 395                 400 


Thr Leu Val Arg Val Phe Leu Tyr Ser Leu Gly Arg Asn Pro Ala Leu 
                405                 410                 415     


Phe Pro Arg Pro Glu Arg Tyr Asn Pro Gln Arg Trp Leu Asp Ile Arg 
            420                 425                 430         


Gly Ser Gly Arg Asn Phe Tyr His Val Pro Phe Gly Phe Gly Met Arg 
        435                 440                 445             


Gln Cys Leu Gly Arg Arg Leu Ala Glu Ala Glu Met Leu Leu Leu Leu 
    450                 455                 460                 


His His Val Leu Lys His Leu Gln Val Glu Thr Leu Thr Gln Glu Asp 
465                 470                 475                 480 


Ile Lys Met Val Tyr Ser Phe Ile Leu Arg Pro Ser Met Phe Pro Leu 
                485                 490                 495     


Leu Thr Phe Arg Ala Ile Asn 
            500             


<210>  2799
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP11B2__Homo_sapiens__NP_000489

<400>  2799

Met Ala Leu Arg Ala Lys Ala Glu Val Cys Val Ala Ala Pro Trp Leu 
1               5                   10                  15      


Ser Leu Gln Arg Ala Arg Ala Leu Gly Thr Arg Ala Ala Arg Ala Pro 
            20                  25                  30          


Arg Thr Val Leu Pro Phe Glu Ala Met Pro Gln His Pro Gly Asn Arg 
        35                  40                  45              


Trp Leu Arg Leu Leu Gln Ile Trp Arg Glu Gln Gly Tyr Glu His Leu 
    50                  55                  60                  


His Leu Glu Met His Gln Thr Phe Gln Glu Leu Gly Pro Ile Phe Arg 
65                  70                  75                  80  


Tyr Asn Leu Gly Gly Pro Arg Met Val Cys Val Met Leu Pro Glu Asp 
                85                  90                  95      


Val Glu Lys Leu Gln Gln Val Asp Ser Leu His Pro Cys Arg Met Ile 
            100                 105                 110         


Leu Glu Pro Trp Val Ala Tyr Arg Gln His Arg Gly His Lys Cys Gly 
        115                 120                 125             


Val Phe Leu Leu Asn Gly Pro Glu Trp Arg Phe Asn Arg Leu Arg Leu 
    130                 135                 140                 


Asn Pro Asp Val Leu Ser Pro Lys Ala Val Gln Arg Phe Leu Pro Met 
145                 150                 155                 160 


Val Asp Ala Val Ala Arg Asp Phe Ser Gln Ala Leu Lys Lys Lys Val 
                165                 170                 175     


Leu Gln Asn Ala Arg Gly Ser Leu Thr Leu Asp Val Gln Pro Ser Ile 
            180                 185                 190         


Phe His Tyr Thr Ile Glu Ala Ser Asn Leu Ala Leu Phe Gly Glu Arg 
        195                 200                 205             


Leu Gly Leu Val Gly His Ser Pro Ser Ser Ala Ser Leu Asn Phe Leu 
    210                 215                 220                 


His Ala Leu Glu Val Met Phe Lys Ser Thr Val Gln Leu Met Phe Met 
225                 230                 235                 240 


Pro Arg Ser Leu Ser Arg Trp Ile Ser Pro Lys Val Trp Lys Glu His 
                245                 250                 255     


Phe Glu Ala Trp Asp Cys Ile Phe Gln Tyr Gly Asp Asn Cys Ile Gln 
            260                 265                 270         


Lys Ile Tyr Gln Glu Leu Ala Phe Asn Arg Pro Gln His Tyr Thr Gly 
        275                 280                 285             


Ile Val Ala Glu Leu Leu Leu Lys Ala Glu Leu Ser Leu Glu Ala Ile 
    290                 295                 300                 


Lys Ala Asn Ser Met Glu Leu Thr Ala Gly Ser Val Asp Thr Thr Ala 
305                 310                 315                 320 


Phe Pro Leu Leu Met Thr Leu Phe Glu Leu Ala Arg Asn Pro Asp Val 
                325                 330                 335     


Gln Gln Ile Leu Arg Gln Glu Ser Leu Ala Ala Ala Ala Ser Ile Ser 
            340                 345                 350         


Glu His Pro Gln Lys Ala Thr Thr Glu Leu Pro Leu Leu Arg Ala Ala 
        355                 360                 365             


Leu Lys Glu Thr Leu Arg Leu Tyr Pro Val Gly Leu Phe Leu Glu Arg 
    370                 375                 380                 


Val Val Ser Ser Asp Leu Val Leu Gln Asn Tyr His Ile Pro Ala Gly 
385                 390                 395                 400 


Thr Leu Val Gln Val Phe Leu Tyr Ser Leu Gly Arg Asn Ala Ala Leu 
                405                 410                 415     


Phe Pro Arg Pro Glu Arg Tyr Asn Pro Gln Arg Trp Leu Asp Ile Arg 
            420                 425                 430         


Gly Ser Gly Arg Asn Phe His His Val Pro Phe Gly Phe Gly Met Arg 
        435                 440                 445             


Gln Cys Leu Gly Arg Arg Leu Ala Glu Ala Glu Met Leu Leu Leu Leu 
    450                 455                 460                 


His His Val Leu Lys His Phe Leu Val Glu Thr Leu Thr Gln Glu Asp 
465                 470                 475                 480 


Ile Lys Met Val Tyr Ser Phe Ile Leu Arg Pro Gly Thr Ser Pro Leu 
                485                 490                 495     


Leu Thr Phe Arg Ala Ile Asn 
            500             


<210>  2800
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP17A1__Homo_sapiens__NP_000093

<400>  2800

Met Trp Glu Leu Val Ala Leu Leu Leu Leu Thr Leu Ala Tyr Leu Phe 
1               5                   10                  15      


Trp Pro Lys Arg Arg Cys Pro Gly Ala Lys Tyr Pro Lys Ser Leu Leu 
            20                  25                  30          


Ser Leu Pro Leu Val Gly Ser Leu Pro Phe Leu Pro Arg His Gly His 
        35                  40                  45              


Met His Asn Asn Phe Phe Lys Leu Gln Lys Lys Tyr Gly Pro Ile Tyr 
    50                  55                  60                  


Ser Val Arg Met Gly Thr Lys Thr Thr Val Ile Val Gly His His Gln 
65                  70                  75                  80  


Leu Ala Lys Glu Val Leu Ile Lys Lys Gly Lys Asp Phe Ser Gly Arg 
                85                  90                  95      


Pro Gln Met Ala Thr Leu Asp Ile Ala Ser Asn Asn Arg Lys Gly Ile 
            100                 105                 110         


Ala Phe Ala Asp Ser Gly Ala His Trp Gln Leu His Arg Arg Leu Ala 
        115                 120                 125             


Met Ala Thr Phe Ala Leu Phe Lys Asp Gly Asp Gln Lys Leu Glu Lys 
    130                 135                 140                 


Ile Ile Cys Gln Glu Ile Ser Thr Leu Cys Asp Met Leu Ala Thr His 
145                 150                 155                 160 


Asn Gly Gln Ser Ile Asp Ile Ser Phe Pro Val Phe Val Ala Val Thr 
                165                 170                 175     


Asn Val Ile Ser Leu Ile Cys Phe Asn Thr Ser Tyr Lys Asn Gly Asp 
            180                 185                 190         


Pro Glu Leu Asn Val Ile Gln Asn Tyr Asn Glu Gly Ile Ile Asp Asn 
        195                 200                 205             


Leu Ser Lys Asp Ser Leu Val Asp Leu Val Pro Trp Leu Lys Ile Phe 
    210                 215                 220                 


Pro Asn Lys Thr Leu Glu Lys Leu Lys Ser His Val Lys Ile Arg Asn 
225                 230                 235                 240 


Asp Leu Leu Asn Lys Ile Leu Glu Asn Tyr Lys Glu Lys Phe Arg Ser 
                245                 250                 255     


Asp Ser Ile Thr Asn Met Leu Asp Thr Leu Met Gln Ala Lys Met Asn 
            260                 265                 270         


Ser Asp Asn Gly Asn Ala Gly Pro Asp Gln Asp Ser Glu Leu Leu Ser 
        275                 280                 285             


Asp Asn His Ile Leu Thr Thr Ile Gly Asp Ile Phe Gly Ala Gly Val 
    290                 295                 300                 


Glu Thr Thr Thr Ser Val Val Lys Trp Thr Leu Ala Phe Leu Leu His 
305                 310                 315                 320 


Asn Pro Gln Val Lys Lys Lys Leu Tyr Glu Glu Ile Asp Gln Asn Val 
                325                 330                 335     


Gly Phe Ser Arg Thr Pro Thr Ile Ser Asp Arg Asn Arg Leu Leu Leu 
            340                 345                 350         


Leu Glu Ala Thr Ile Arg Glu Val Leu Arg Leu Arg Pro Val Ala Pro 
        355                 360                 365             


Met Leu Ile Pro His Lys Ala Asn Val Asp Ser Ser Ile Gly Glu Phe 
    370                 375                 380                 


Ala Val Asp Lys Gly Thr Glu Val Ile Ile Asn Leu Trp Ala Leu His 
385                 390                 395                 400 


His Asn Glu Lys Glu Trp His Gln Pro Asp Gln Phe Met Pro Glu Arg 
                405                 410                 415     


Phe Leu Asn Pro Ala Gly Thr Gln Leu Ile Ser Pro Ser Val Ser Tyr 
            420                 425                 430         


Leu Pro Phe Gly Ala Gly Pro Arg Ser Cys Ile Gly Glu Ile Leu Ala 
        435                 440                 445             


Arg Gln Glu Leu Phe Leu Ile Met Ala Trp Leu Leu Gln Arg Phe Asp 
    450                 455                 460                 


Leu Glu Val Pro Asp Asp Gly Gln Leu Pro Ser Leu Glu Gly Ile Pro 
465                 470                 475                 480 


Lys Val Val Phe Leu Ile Asp Ser Phe Lys Val Lys Ile Lys Val Arg 
                485                 490                 495     


Gln Ala Trp Arg Glu Ala Gln Ala Glu Gly Ser Thr 
            500                 505             


<210>  2801
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP19A1__Homo_sapiens__NP_112503

<400>  2801

Met Val Leu Glu Met Leu Asn Pro Ile His Tyr Asn Ile Thr Ser Ile 
1               5                   10                  15      


Val Pro Glu Ala Met Pro Ala Ala Thr Met Pro Val Leu Leu Leu Thr 
            20                  25                  30          


Gly Leu Phe Leu Leu Val Trp Asn Tyr Glu Gly Thr Ser Ser Ile Pro 
        35                  40                  45              


Gly Pro Gly Tyr Cys Met Gly Ile Gly Pro Leu Ile Ser His Gly Arg 
    50                  55                  60                  


Phe Leu Trp Met Gly Ile Gly Ser Ala Cys Asn Tyr Tyr Asn Arg Val 
65                  70                  75                  80  


Tyr Gly Glu Phe Met Arg Val Trp Ile Ser Gly Glu Glu Thr Leu Ile 
                85                  90                  95      


Ile Ser Lys Ser Ser Ser Met Phe His Ile Met Lys His Asn His Tyr 
            100                 105                 110         


Ser Ser Arg Phe Gly Ser Lys Leu Gly Leu Gln Cys Ile Gly Met His 
        115                 120                 125             


Glu Lys Gly Ile Ile Phe Asn Asn Asn Pro Glu Leu Trp Lys Thr Thr 
    130                 135                 140                 


Arg Pro Phe Phe Met Lys Ala Leu Ser Gly Pro Gly Leu Val Arg Met 
145                 150                 155                 160 


Val Thr Val Cys Ala Glu Ser Leu Lys Thr His Leu Asp Arg Leu Glu 
                165                 170                 175     


Glu Val Thr Asn Glu Ser Gly Tyr Val Asp Val Leu Thr Leu Leu Arg 
            180                 185                 190         


Arg Val Met Leu Asp Thr Ser Asn Thr Leu Phe Leu Arg Ile Pro Leu 
        195                 200                 205             


Asp Glu Ser Ala Ile Val Val Lys Ile Gln Gly Tyr Phe Asp Ala Trp 
    210                 215                 220                 


Gln Ala Leu Leu Ile Lys Pro Asp Ile Phe Phe Lys Ile Ser Trp Leu 
225                 230                 235                 240 


Tyr Lys Lys Tyr Glu Lys Ser Val Lys Asp Leu Lys Asp Ala Ile Glu 
                245                 250                 255     


Val Leu Ile Ala Glu Lys Arg Arg Arg Ile Ser Thr Glu Glu Lys Leu 
            260                 265                 270         


Glu Glu Cys Met Asp Phe Ala Thr Glu Leu Ile Leu Ala Glu Lys Arg 
        275                 280                 285             


Gly Asp Leu Thr Arg Glu Asn Val Asn Gln Cys Ile Leu Glu Met Leu 
    290                 295                 300                 


Ile Ala Ala Pro Asp Thr Met Ser Val Ser Leu Phe Phe Met Leu Phe 
305                 310                 315                 320 


Leu Ile Ala Lys His Pro Asn Val Glu Glu Ala Ile Ile Lys Glu Ile 
                325                 330                 335     


Gln Thr Val Ile Gly Glu Arg Asp Ile Lys Ile Asp Asp Ile Gln Lys 
            340                 345                 350         


Leu Lys Val Met Glu Asn Phe Ile Tyr Glu Ser Met Arg Tyr Gln Pro 
        355                 360                 365             


Val Val Asp Leu Val Met Arg Lys Ala Leu Glu Asp Asp Val Ile Asp 
    370                 375                 380                 


Gly Tyr Pro Val Lys Lys Gly Thr Asn Ile Ile Leu Asn Ile Gly Arg 
385                 390                 395                 400 


Met His Arg Leu Glu Phe Phe Pro Lys Pro Asn Glu Phe Thr Leu Glu 
                405                 410                 415     


Asn Phe Ala Lys Asn Val Pro Tyr Arg Tyr Phe Gln Pro Phe Gly Phe 
            420                 425                 430         


Gly Pro Arg Gly Cys Ala Gly Lys Tyr Ile Ala Met Val Met Met Lys 
        435                 440                 445             


Ala Ile Leu Val Thr Leu Leu Arg Arg Phe His Val Lys Thr Leu Gln 
    450                 455                 460                 


Gly Gln Cys Val Glu Ser Ile Gln Lys Ile His Asp Leu Ser Leu His 
465                 470                 475                 480 


Pro Asp Glu Thr Lys Asn Met Leu Glu Met Ile Phe Thr Pro Arg Asn 
                485                 490                 495     


Ser Asp Arg Cys Leu Glu His 
            500             


<210>  2802
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP1A1__Homo_sapiens__NP_000490

<400>  2802

Met Leu Phe Pro Ile Ser Met Ser Ala Thr Glu Phe Leu Leu Ala Ser 
1               5                   10                  15      


Val Ile Phe Cys Leu Val Phe Trp Val Ile Arg Ala Ser Arg Pro Gln 
            20                  25                  30          


Val Pro Lys Gly Leu Lys Asn Pro Pro Gly Pro Trp Gly Trp Pro Leu 
        35                  40                  45              


Ile Gly His Met Leu Thr Leu Gly Lys Asn Pro His Leu Ala Leu Ser 
    50                  55                  60                  


Arg Met Ser Gln Gln Tyr Gly Asp Val Leu Gln Ile Arg Ile Gly Ser 
65                  70                  75                  80  


Thr Pro Val Val Val Leu Ser Gly Leu Asp Thr Ile Arg Gln Ala Leu 
                85                  90                  95      


Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr Thr Phe 
            100                 105                 110         


Thr Leu Ile Ser Asn Gly Gln Ser Met Ser Phe Ser Pro Asp Ser Gly 
        115                 120                 125             


Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Gly Leu Lys Ser 
    130                 135                 140                 


Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Thr Ser Cys Tyr Leu Glu 
145                 150                 155                 160 


Glu His Val Ser Lys Glu Ala Glu Val Leu Ile Ser Thr Leu Gln Glu 
                165                 170                 175     


Leu Met Ala Gly Pro Gly His Phe Asn Pro Tyr Arg Tyr Val Val Val 
            180                 185                 190         


Ser Val Thr Asn Val Ile Cys Ala Ile Cys Phe Gly Arg Arg Tyr Asp 
        195                 200                 205             


His Asn His Gln Glu Leu Leu Ser Leu Val Asn Leu Asn Asn Asn Phe 
    210                 215                 220                 


Gly Glu Val Val Gly Ser Gly Asn Pro Ala Asp Phe Ile Pro Ile Leu 
225                 230                 235                 240 


Arg Tyr Leu Pro Asn Pro Ser Leu Asn Ala Phe Lys Asp Leu Asn Glu 
                245                 250                 255     


Lys Phe Tyr Ser Phe Met Gln Lys Met Val Lys Glu His Tyr Lys Thr 
            260                 265                 270         


Phe Glu Lys Gly His Ile Arg Asp Ile Thr Asp Ser Leu Ile Glu His 
        275                 280                 285             


Cys Gln Glu Lys Gln Leu Asp Glu Asn Ala Asn Val Gln Leu Ser Asp 
    290                 295                 300                 


Glu Lys Ile Ile Asn Ile Val Leu Asp Leu Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Met Asn 
                325                 330                 335     


Pro Arg Val Gln Arg Lys Ile Gln Glu Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Ser Arg Arg Pro Arg Leu Ser Asp Arg Ser His Leu Pro Tyr Met 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Val Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Ser Leu Lys Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Gly Arg Cys Val Phe Val Asn Gln Trp Gln Ile Asn His 
                405                 410                 415     


Asp Gln Lys Leu Trp Val Asn Pro Ser Glu Phe Leu Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Pro Asp Gly Ala Ile Asp Lys Val Leu Ser Glu Lys Val Ile 
        435                 440                 445             


Ile Phe Gly Met Gly Lys Arg Lys Cys Ile Gly Glu Thr Ile Ala Arg 
    450                 455                 460                 


Trp Glu Val Phe Leu Phe Leu Ala Ile Leu Leu Gln Arg Val Glu Phe 
465                 470                 475                 480 


Ser Val Pro Leu Gly Val Lys Val Asp Met Thr Pro Ile Tyr Gly Leu 
                485                 490                 495     


Thr Met Lys His Ala Cys Cys Glu His Phe Gln Met Gln Leu Arg Ser 
            500                 505                 510         


<210>  2803
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP1A2__Homo_sapiens__NP_000752

<400>  2803

Met Ala Leu Ser Gln Ser Val Pro Phe Ser Ala Thr Glu Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ala Ile Phe Cys Leu Val Phe Trp Val Leu Lys Gly Leu Arg 
            20                  25                  30          


Pro Arg Val Pro Lys Gly Leu Lys Ser Pro Pro Glu Pro Trp Gly Trp 
        35                  40                  45              


Pro Leu Leu Gly His Val Leu Thr Leu Gly Lys Asn Pro His Leu Ala 
    50                  55                  60                  


Leu Ser Arg Met Ser Gln Arg Tyr Gly Asp Val Leu Gln Ile Arg Ile 
65                  70                  75                  80  


Gly Ser Thr Pro Val Leu Val Leu Ser Arg Leu Asp Thr Ile Arg Gln 
                85                  90                  95      


Ala Leu Val Arg Gln Gly Asp Asp Phe Lys Gly Arg Pro Asp Leu Tyr 
            100                 105                 110         


Thr Ser Thr Leu Ile Thr Asp Gly Gln Ser Leu Thr Phe Ser Thr Asp 
        115                 120                 125             


Ser Gly Pro Val Trp Ala Ala Arg Arg Arg Leu Ala Gln Asn Ala Leu 
    130                 135                 140                 


Asn Thr Phe Ser Ile Ala Ser Asp Pro Ala Ser Ser Ser Ser Cys Tyr 
145                 150                 155                 160 


Leu Glu Glu His Val Ser Lys Glu Ala Lys Ala Leu Ile Ser Arg Leu 
                165                 170                 175     


Gln Glu Leu Met Ala Gly Pro Gly His Phe Asp Pro Tyr Asn Gln Val 
            180                 185                 190         


Val Val Ser Val Ala Asn Val Ile Gly Ala Met Cys Phe Gly Gln His 
        195                 200                 205             


Phe Pro Glu Ser Ser Asp Glu Met Leu Ser Leu Val Lys Asn Thr His 
    210                 215                 220                 


Glu Phe Val Glu Thr Ala Ser Ser Gly Asn Pro Leu Asp Phe Phe Pro 
225                 230                 235                 240 


Ile Leu Arg Tyr Leu Pro Asn Pro Ala Leu Gln Arg Phe Lys Ala Phe 
                245                 250                 255     


Asn Gln Arg Phe Leu Trp Phe Leu Gln Lys Thr Val Gln Glu His Tyr 
            260                 265                 270         


Gln Asp Phe Asp Lys Asn Ser Val Arg Asp Ile Thr Gly Ala Leu Phe 
        275                 280                 285             


Lys His Ser Lys Lys Gly Pro Arg Ala Ser Gly Asn Leu Ile Pro Gln 
    290                 295                 300                 


Glu Lys Ile Val Asn Leu Val Asn Asp Ile Phe Gly Ala Gly Phe Asp 
305                 310                 315                 320 


Thr Val Thr Thr Ala Ile Ser Trp Ser Leu Met Tyr Leu Val Thr Lys 
                325                 330                 335     


Pro Glu Ile Gln Arg Lys Ile Gln Lys Glu Leu Asp Thr Val Ile Gly 
            340                 345                 350         


Arg Glu Arg Arg Pro Arg Leu Ser Asp Arg Pro Gln Leu Pro Tyr Leu 
        355                 360                 365             


Glu Ala Phe Ile Leu Glu Thr Phe Arg His Ser Ser Phe Leu Pro Phe 
    370                 375                 380                 


Thr Ile Pro His Ser Thr Thr Arg Asp Thr Thr Leu Asn Gly Phe Tyr 
385                 390                 395                 400 


Ile Pro Lys Lys Cys Cys Val Phe Val Asn Gln Trp Gln Val Asn His 
                405                 410                 415     


Asp Pro Glu Leu Trp Glu Asp Pro Ser Glu Phe Arg Pro Glu Arg Phe 
            420                 425                 430         


Leu Thr Ala Asp Gly Thr Ala Ile Asn Lys Pro Leu Ser Glu Lys Met 
        435                 440                 445             


Met Leu Phe Gly Met Gly Lys Arg Arg Cys Ile Gly Glu Val Leu Ala 
    450                 455                 460                 


Lys Trp Glu Ile Phe Leu Phe Leu Ala Ile Leu Leu Gln Gln Leu Glu 
465                 470                 475                 480 


Phe Ser Val Pro Pro Gly Val Lys Val Asp Leu Thr Pro Ile Tyr Gly 
                485                 490                 495     


Leu Thr Met Lys His Ala Arg Cys Glu His Val Gln Ala Arg Leu Arg 
            500                 505                 510         


Phe Ser Ile Asn 
        515     


<210>  2804
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP1B1__Homo_sapiens__NP_000095

<400>  2804

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  2805
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP21A2__Homo_sapiens__NP_000491

<400>  2805

Met Leu Leu Leu Gly Leu Leu Leu Leu Leu Pro Leu Leu Ala Gly Ala 
1               5                   10                  15      


Arg Leu Leu Trp Asn Trp Trp Lys Leu Arg Ser Leu His Leu Pro Pro 
            20                  25                  30          


Leu Ala Pro Gly Phe Leu His Leu Leu Gln Pro Asp Leu Pro Ile Tyr 
        35                  40                  45              


Leu Leu Gly Leu Thr Gln Lys Phe Gly Pro Ile Tyr Arg Leu His Leu 
    50                  55                  60                  


Gly Leu Gln Asp Val Val Val Leu Asn Ser Lys Arg Thr Ile Glu Glu 
65                  70                  75                  80  


Ala Met Val Lys Lys Trp Ala Asp Phe Ala Gly Arg Pro Glu Pro Leu 
                85                  90                  95      


Thr Tyr Lys Leu Val Ser Arg Asn Tyr Pro Asp Leu Ser Leu Gly Asp 
            100                 105                 110         


Tyr Ser Leu Leu Trp Lys Ala His Lys Lys Leu Thr Arg Ser Ala Leu 
        115                 120                 125             


Leu Leu Gly Ile Arg Asp Ser Met Glu Pro Val Val Glu Gln Leu Thr 
    130                 135                 140                 


Gln Glu Phe Cys Glu Arg Met Arg Ala Gln Pro Gly Thr Pro Val Ala 
145                 150                 155                 160 


Ile Glu Glu Glu Phe Ser Leu Leu Thr Cys Ser Ile Ile Cys Tyr Leu 
                165                 170                 175     


Thr Phe Gly Asp Lys Ile Lys Asp Asp Asn Leu Met Pro Ala Tyr Tyr 
            180                 185                 190         


Lys Cys Ile Gln Glu Val Leu Lys Thr Trp Ser His Trp Ser Ile Gln 
        195                 200                 205             


Ile Val Asp Val Ile Pro Phe Leu Arg Phe Phe Pro Asn Pro Gly Leu 
    210                 215                 220                 


Arg Arg Leu Lys Gln Ala Ile Glu Lys Arg Asp His Ile Val Glu Met 
225                 230                 235                 240 


Gln Leu Arg Gln His Lys Glu Ser Leu Val Ala Gly Gln Trp Arg Asp 
                245                 250                 255     


Met Met Asp Tyr Met Leu Gln Gly Val Ala Gln Pro Ser Met Glu Glu 
            260                 265                 270         


Gly Ser Gly Gln Leu Leu Glu Gly His Val His Met Ala Ala Val Asp 
        275                 280                 285             


Leu Leu Ile Gly Gly Thr Glu Thr Thr Ala Asn Thr Leu Ser Trp Ala 
    290                 295                 300                 


Val Val Phe Leu Leu His His Pro Glu Ile Gln Gln Arg Leu Gln Glu 
305                 310                 315                 320 


Glu Leu Asp His Glu Leu Gly Pro Gly Ala Ser Ser Ser Arg Val Pro 
                325                 330                 335     


Tyr Lys Asp Arg Ala Arg Leu Pro Leu Leu Asn Ala Thr Ile Ala Glu 
            340                 345                 350         


Val Leu Arg Leu Arg Pro Val Val Pro Leu Ala Leu Pro His Arg Thr 
        355                 360                 365             


Thr Arg Pro Ser Ser Ile Ser Gly Tyr Asp Ile Pro Glu Gly Thr Val 
    370                 375                 380                 


Ile Ile Pro Asn Leu Gln Gly Ala His Leu Asp Glu Thr Val Trp Glu 
385                 390                 395                 400 


Arg Pro His Glu Phe Trp Pro Asp Arg Phe Leu Glu Pro Gly Lys Asn 
                405                 410                 415     


Ser Arg Ala Leu Ala Phe Gly Cys Gly Ala Arg Val Cys Leu Gly Glu 
            420                 425                 430         


Pro Leu Ala Arg Leu Glu Leu Phe Val Val Leu Thr Arg Leu Leu Gln 
        435                 440                 445             


Ala Phe Thr Leu Leu Pro Ser Gly Asp Ala Leu Pro Ser Leu Gln Pro 
    450                 455                 460                 


Leu Pro His Cys Ser Val Ile Leu Lys Met Gln Pro Phe Gln Val Arg 
465                 470                 475                 480 


Leu Gln Pro Arg Gly Met Gly Ala His Ser Pro Gly Gln Ser Gln 
                485                 490                 495 


<210>  2806
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP24A1__Homo_sapiens__NP_000773

<400>  2806

Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln 
1               5                   10                  15      


Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Thr Ser Thr Ala 
            20                  25                  30          


Tyr Thr Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Thr Ala 
        35                  40                  45              


Gly Gly Glu Thr Gln Asn Ala Ala Ala Leu Pro Gly Pro Thr Ser Trp 
    50                  55                  60                  


Pro Leu Leu Gly Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys 
65                  70                  75                  80  


Lys Gln His Asp Thr Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile 
                85                  90                  95      


Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro 
            100                 105                 110         


Cys Leu Leu Glu Ala Leu Tyr Arg Thr Glu Ser Ala Tyr Pro Gln Arg 
        115                 120                 125             


Leu Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly 
    130                 135                 140                 


Tyr Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser 
145                 150                 155                 160 


Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp 
                165                 170                 175     


Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu 
            180                 185                 190         


Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn 
        195                 200                 205             


Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe 
    210                 215                 220                 


Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met 
225                 230                 235                 240 


Ala Ile Lys Thr Met Met Ser Thr Phe Gly Arg Met Met Val Thr Pro 
                245                 250                 255     


Val Glu Leu His Lys Ser Leu Asn Thr Lys Val Trp Gln Asp His Thr 
            260                 265                 270         


Leu Ala Trp Asp Thr Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn 
        275                 280                 285             


Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp 
    290                 295                 300                 


Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val 
305                 310                 315                 320 


Thr Glu Leu Gln Leu Ala Ala Val Glu Thr Thr Ala Asn Ser Leu Met 
                325                 330                 335     


Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu 
            340                 345                 350         


Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro Arg Ala 
        355                 360                 365             


Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser 
    370                 375                 380                 


Met Arg Leu Thr Pro Ser Val Pro Phe Thr Thr Arg Thr Leu Asp Lys 
385                 390                 395                 400 


Ala Thr Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Thr Val Leu Met 
                405                 410                 415     


Leu Asn Thr Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu Asp Ser 
            420                 425                 430         


Ser Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys Ile Asn 
        435                 440                 445             


Pro Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys Ile Gly 
    450                 455                 460                 


Arg Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp Ile Val 
465                 470                 475                 480 


Arg Lys Tyr Asp Ile Gln Ala Thr Asp Asn Glu Pro Val Glu Met Leu 
                485                 490                 495     


His Ser Gly Thr Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys 
            500                 505                 510         


Gln Arg 
        


<210>  2807
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP26A1__Homo_sapiens__NP_000774

<400>  2807

Met Gly Leu Pro Ala Leu Leu Ala Ser Ala Leu Cys Thr Phe Val Leu 
1               5                   10                  15      


Pro Leu Leu Leu Phe Leu Ala Ala Ile Lys Leu Trp Asp Leu Tyr Cys 
            20                  25                  30          


Val Ser Gly Arg Asp Arg Ser Cys Ala Leu Pro Leu Pro Pro Gly Thr 
        35                  40                  45              


Met Gly Phe Pro Phe Phe Gly Glu Thr Leu Gln Met Val Leu Gln Arg 
    50                  55                  60                  


Arg Lys Phe Leu Gln Met Lys Arg Arg Lys Tyr Gly Phe Ile Tyr Lys 
65                  70                  75                  80  


Thr His Leu Phe Gly Arg Pro Thr Val Arg Val Met Gly Ala Asp Asn 
                85                  90                  95      


Val Arg Arg Ile Leu Leu Gly Glu His Arg Leu Val Ser Val His Trp 
            100                 105                 110         


Pro Ala Ser Val Arg Thr Ile Leu Gly Ser Gly Cys Leu Ser Asn Leu 
        115                 120                 125             


His Asp Ser Ser His Lys Gln Arg Lys Lys Val Ile Met Arg Ala Phe 
    130                 135                 140                 


Ser Arg Glu Ala Leu Glu Cys Tyr Val Pro Val Ile Thr Glu Glu Val 
145                 150                 155                 160 


Gly Ser Ser Leu Glu Gln Trp Leu Ser Cys Gly Glu Arg Gly Leu Leu 
                165                 170                 175     


Val Tyr Pro Glu Val Lys Arg Leu Met Phe Arg Ile Ala Met Arg Ile 
            180                 185                 190         


Leu Leu Gly Cys Glu Pro Gln Leu Ala Gly Asp Gly Asp Ser Glu Gln 
        195                 200                 205             


Gln Leu Val Glu Ala Phe Glu Glu Met Thr Arg Asn Leu Phe Ser Leu 
    210                 215                 220                 


Pro Ile Asp Val Pro Phe Ser Gly Leu Tyr Arg Gly Met Lys Ala Arg 
225                 230                 235                 240 


Asn Leu Ile His Ala Arg Ile Glu Gln Asn Ile Arg Ala Lys Ile Cys 
                245                 250                 255     


Gly Leu Arg Ala Ser Glu Ala Gly Gln Gly Cys Lys Asp Ala Leu Gln 
            260                 265                 270         


Leu Leu Ile Glu His Ser Trp Glu Arg Gly Glu Arg Leu Asp Met Gln 
        275                 280                 285             


Ala Leu Lys Gln Ser Ser Thr Glu Leu Leu Phe Gly Gly His Glu Thr 
    290                 295                 300                 


Thr Ala Ser Ala Ala Thr Ser Leu Ile Thr Tyr Leu Gly Leu Tyr Pro 
305                 310                 315                 320 


His Val Leu Gln Lys Val Arg Glu Glu Leu Lys Ser Lys Gly Leu Leu 
                325                 330                 335     


Cys Lys Ser Asn Gln Asp Asn Lys Leu Asp Met Glu Ile Leu Glu Gln 
            340                 345                 350         


Leu Lys Tyr Ile Gly Cys Val Ile Lys Glu Thr Leu Arg Leu Asn Pro 
        355                 360                 365             


Pro Val Pro Gly Gly Phe Arg Val Ala Leu Lys Thr Phe Glu Leu Asn 
    370                 375                 380                 


Gly Tyr Gln Ile Pro Lys Gly Trp Asn Val Ile Tyr Ser Ile Cys Asp 
385                 390                 395                 400 


Thr His Asp Val Ala Glu Ile Phe Thr Asn Lys Glu Glu Phe Asn Pro 
                405                 410                 415     


Asp Arg Phe Met Leu Pro His Pro Glu Asp Ala Ser Arg Phe Ser Phe 
            420                 425                 430         


Ile Pro Phe Gly Gly Gly Leu Arg Ser Cys Val Gly Lys Glu Phe Ala 
        435                 440                 445             


Lys Ile Leu Leu Lys Ile Phe Thr Val Glu Leu Ala Arg His Cys Asp 
    450                 455                 460                 


Trp Gln Leu Leu Asn Gly Pro Pro Thr Met Lys Thr Ser Pro Thr Val 
465                 470                 475                 480 


Tyr Pro Val Asp Asn Leu Pro Ala Arg Phe Thr His Phe His Gly Glu 
                485                 490                 495     


Ile 
    


<210>  2808
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP26B1__Homo_sapiens__NP_001264671

<400>  2808

Met Leu Phe Glu Gly Leu Asp Leu Val Ser Ala Leu Ala Thr Leu Ala 
1               5                   10                  15      


Ala Cys Leu Val Ser Val Thr Leu Leu Leu Ala Val Ser Gln Gln Leu 
            20                  25                  30          


Trp Gln Leu Arg Trp Ala Ala Thr Arg Asp Lys Ser Cys Lys Leu Pro 
        35                  40                  45              


Ile Pro Lys Gly Ser Met Gly Phe Pro Leu Ile Gly Glu Thr Gly His 
    50                  55                  60                  


Trp Leu Leu Gln Val Phe Ser Lys Ile Phe Ser His Glu Ala Leu Glu 
65                  70                  75                  80  


Ser Tyr Leu Pro Lys Ile Gln Leu Val Ile Gln Asp Thr Leu Arg Ala 
                85                  90                  95      


Trp Ser Ser His Pro Glu Ala Ile Asn Val Tyr Gln Glu Ala Gln Lys 
            100                 105                 110         


Leu Thr Phe Arg Met Ala Ile Arg Val Leu Leu Gly Phe Ser Ile Pro 
        115                 120                 125             


Glu Glu Asp Leu Gly His Leu Phe Glu Val Tyr Gln Gln Phe Val Asp 
    130                 135                 140                 


Asn Val Phe Ser Leu Pro Val Asp Leu Pro Phe Ser Gly Tyr Arg Arg 
145                 150                 155                 160 


Gly Ile Gln Ala Arg Gln Ile Leu Gln Lys Gly Leu Glu Lys Ala Ile 
                165                 170                 175     


Arg Glu Lys Leu Gln Cys Thr Gln Gly Lys Asp Tyr Leu Asp Ala Leu 
            180                 185                 190         


Asp Leu Leu Ile Glu Ser Ser Lys Glu His Gly Lys Glu Met Thr Met 
        195                 200                 205             


Gln Glu Leu Lys Asp Gly Thr Leu Glu Leu Ile Phe Ala Ala Tyr Ala 
    210                 215                 220                 


Thr Thr Ala Ser Ala Ser Thr Ser Leu Ile Met Gln Leu Leu Lys His 
225                 230                 235                 240 


Pro Thr Val Leu Glu Lys Leu Arg Asp Glu Leu Arg Ala His Gly Ile 
                245                 250                 255     


Leu His Ser Gly Gly Cys Pro Cys Glu Gly Thr Leu Arg Leu Asp Thr 
            260                 265                 270         


Leu Ser Gly Leu Arg Tyr Leu Asp Cys Val Ile Lys Glu Val Met Arg 
        275                 280                 285             


Leu Phe Thr Pro Ile Ser Gly Gly Tyr Arg Thr Val Leu Gln Thr Phe 
    290                 295                 300                 


Glu Leu Asp Gly Phe Gln Ile Pro Lys Gly Trp Ser Val Met Tyr Ser 
305                 310                 315                 320 


Ile Arg Asp Thr His Asp Thr Ala Pro Val Phe Lys Asp Val Asn Val 
                325                 330                 335     


Phe Asp Pro Asp Arg Phe Ser Gln Ala Arg Ser Glu Asp Lys Asp Gly 
            340                 345                 350         


Arg Phe His Tyr Leu Pro Phe Gly Gly Gly Val Arg Thr Cys Leu Gly 
        355                 360                 365             


Lys His Leu Ala Lys Leu Phe Leu Lys Val Leu Ala Val Glu Leu Ala 
    370                 375                 380                 


Ser Thr Ser Arg Phe Glu Leu Ala Thr Arg Thr Phe Pro Arg Ile Thr 
385                 390                 395                 400 


Leu Val Pro Val Leu His Pro Val Asp Gly Leu Ser Val Lys Phe Phe 
                405                 410                 415     


Gly Leu Asp Ser Asn Gln Asn Glu Ile Leu Pro Glu Thr Glu Ala Met 
            420                 425                 430         


Leu Ser Ala Thr Val 
        435         


<210>  2809
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP26C1__Homo_sapiens__NP_899230

<400>  2809

Met Phe Pro Trp Gly Leu Ser Cys Leu Ser Val Leu Gly Ala Ala Gly 
1               5                   10                  15      


Thr Ala Leu Leu Cys Ala Gly Leu Leu Leu Ser Leu Ala Gln His Leu 
            20                  25                  30          


Trp Thr Leu Arg Trp Met Leu Ser Arg Asp Arg Ala Ser Thr Leu Pro 
        35                  40                  45              


Leu Pro Lys Gly Ser Met Gly Trp Pro Phe Phe Gly Glu Thr Leu His 
    50                  55                  60                  


Trp Leu Val Gln Gly Ser Arg Phe His Ser Ser Arg Arg Glu Arg Tyr 
65                  70                  75                  80  


Gly Thr Val Phe Lys Thr His Leu Leu Gly Arg Pro Val Ile Arg Val 
                85                  90                  95      


Ser Gly Ala Glu Asn Val Arg Thr Ile Leu Leu Gly Glu His Arg Leu 
            100                 105                 110         


Val Arg Ser Gln Trp Pro Gln Ser Ala His Ile Leu Leu Gly Ser His 
        115                 120                 125             


Thr Leu Leu Gly Ala Val Gly Glu Pro His Arg Arg Arg Arg Lys Val 
    130                 135                 140                 


Leu Ala Arg Val Phe Ser Arg Ala Ala Leu Glu Arg Tyr Val Pro Arg 
145                 150                 155                 160 


Leu Gln Gly Ala Leu Arg His Glu Val Arg Ser Trp Cys Ala Ala Gly 
                165                 170                 175     


Gly Pro Val Ser Val Tyr Asp Ala Ser Lys Ala Leu Thr Phe Arg Met 
            180                 185                 190         


Ala Ala Arg Ile Leu Leu Gly Leu Arg Leu Asp Glu Ala Gln Cys Ala 
        195                 200                 205             


Thr Leu Ala Arg Thr Phe Glu Gln Leu Val Glu Asn Leu Phe Ser Leu 
    210                 215                 220                 


Pro Leu Asp Val Pro Phe Ser Gly Leu Arg Lys Gly Ile Arg Ala Arg 
225                 230                 235                 240 


Asp Gln Leu His Arg His Leu Glu Gly Ala Ile Ser Glu Lys Leu His 
                245                 250                 255     


Glu Asp Lys Ala Ala Glu Pro Gly Asp Ala Leu Asp Leu Ile Ile His 
            260                 265                 270         


Ser Ala Arg Glu Leu Gly His Glu Pro Ser Met Gln Glu Leu Lys Glu 
        275                 280                 285             


Ser Ala Val Glu Leu Leu Phe Ala Ala Phe Phe Thr Thr Ala Ser Ala 
    290                 295                 300                 


Ser Thr Ser Leu Val Leu Leu Leu Leu Gln His Pro Ala Ala Ile Ala 
305                 310                 315                 320 


Lys Ile Arg Glu Glu Leu Val Ala Gln Gly Leu Gly Arg Ala Cys Gly 
                325                 330                 335     


Cys Ala Pro Gly Ala Ala Gly Gly Ser Glu Gly Pro Pro Pro Asp Cys 
            340                 345                 350         


Gly Cys Glu Pro Asp Leu Ser Leu Ala Ala Leu Gly Arg Leu Arg Tyr 
        355                 360                 365             


Val Asp Cys Val Val Lys Glu Val Leu Arg Leu Leu Pro Pro Val Ser 
    370                 375                 380                 


Gly Gly Tyr Arg Thr Ala Leu Arg Thr Phe Glu Leu Asp Gly Tyr Gln 
385                 390                 395                 400 


Ile Pro Lys Gly Trp Ser Val Met Tyr Ser Ile Arg Asp Thr His Glu 
                405                 410                 415     


Thr Ala Ala Val Tyr Arg Ser Pro Pro Glu Gly Phe Asp Pro Glu Arg 
            420                 425                 430         


Phe Gly Ala Ala Arg Glu Asp Ser Arg Gly Ala Ser Ser Arg Phe His 
        435                 440                 445             


Tyr Ile Pro Phe Gly Gly Gly Ala Arg Ser Cys Leu Gly Gln Glu Leu 
    450                 455                 460                 


Ala Gln Ala Val Leu Gln Leu Leu Ala Val Glu Leu Val Arg Thr Ala 
465                 470                 475                 480 


Arg Trp Glu Leu Ala Thr Pro Ala Phe Pro Ala Met Gln Thr Val Pro 
                485                 490                 495     


Ile Val His Pro Val Asp Gly Leu Arg Leu Phe Phe His Pro Leu Thr 
            500                 505                 510         


Pro Ser Val Ala Gly Asn Gly Leu Cys Leu 
        515                 520         


<210>  2810
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP27A1__Homo_sapiens__NP_000775

<400>  2810

Met Ala Ala Leu Gly Cys Ala Arg Leu Arg Trp Ala Leu Arg Gly Ala 
1               5                   10                  15      


Gly Arg Gly Leu Cys Pro His Gly Ala Arg Ala Lys Ala Ala Ile Pro 
            20                  25                  30          


Ala Ala Leu Pro Ser Asp Lys Ala Thr Gly Ala Pro Gly Ala Gly Pro 
        35                  40                  45              


Gly Val Arg Arg Arg Gln Arg Ser Leu Glu Glu Ile Pro Arg Leu Gly 
    50                  55                  60                  


Gln Leu Arg Phe Phe Phe Gln Leu Phe Val Gln Gly Tyr Ala Leu Gln 
65                  70                  75                  80  


Leu His Gln Leu Gln Val Leu Tyr Lys Ala Lys Tyr Gly Pro Met Trp 
                85                  90                  95      


Met Ser Tyr Leu Gly Pro Gln Met His Val Asn Leu Ala Ser Ala Pro 
            100                 105                 110         


Leu Leu Glu Gln Val Met Arg Gln Glu Gly Lys Tyr Pro Val Arg Asn 
        115                 120                 125             


Asp Met Glu Leu Trp Lys Glu His Arg Asp Gln His Asp Leu Thr Tyr 
    130                 135                 140                 


Gly Pro Phe Thr Thr Glu Gly His His Trp Tyr Gln Leu Arg Gln Ala 
145                 150                 155                 160 


Leu Asn Gln Arg Leu Leu Lys Pro Ala Glu Ala Ala Leu Tyr Thr Asp 
                165                 170                 175     


Ala Phe Asn Glu Val Ile Asp Asp Phe Met Thr Arg Leu Asp Gln Leu 
            180                 185                 190         


Arg Ala Glu Ser Ala Ser Gly Asn Gln Val Ser Asp Met Ala Gln Leu 
        195                 200                 205             


Phe Tyr Tyr Phe Ala Leu Glu Ala Ile Cys Tyr Ile Leu Phe Glu Lys 
    210                 215                 220                 


Arg Ile Gly Cys Leu Gln Arg Ser Ile Pro Glu Asp Thr Val Thr Phe 
225                 230                 235                 240 


Val Arg Ser Ile Gly Leu Met Phe Gln Asn Ser Leu Tyr Ala Thr Phe 
                245                 250                 255     


Leu Pro Lys Trp Thr Arg Pro Val Leu Pro Phe Trp Lys Arg Tyr Leu 
            260                 265                 270         


Asp Gly Trp Asn Ala Ile Phe Ser Phe Gly Lys Lys Leu Ile Asp Glu 
        275                 280                 285             


Lys Leu Glu Asp Met Glu Ala Gln Leu Gln Ala Ala Gly Pro Asp Gly 
    290                 295                 300                 


Ile Gln Val Ser Gly Tyr Leu His Phe Leu Leu Ala Ser Gly Gln Leu 
305                 310                 315                 320 


Ser Pro Arg Glu Ala Met Gly Ser Leu Pro Glu Leu Leu Met Ala Gly 
                325                 330                 335     


Val Asp Thr Thr Ser Asn Thr Leu Thr Trp Ala Leu Tyr His Leu Ser 
            340                 345                 350         


Lys Asp Pro Glu Ile Gln Glu Ala Leu His Glu Glu Val Val Gly Val 
        355                 360                 365             


Val Pro Ala Gly Gln Val Pro Gln His Lys Asp Phe Ala His Met Pro 
    370                 375                 380                 


Leu Leu Lys Ala Val Leu Lys Glu Thr Leu Arg Leu Tyr Pro Val Val 
385                 390                 395                 400 


Pro Thr Asn Ser Arg Ile Ile Glu Lys Glu Ile Glu Val Asp Gly Phe 
                405                 410                 415     


Leu Phe Pro Lys Asn Thr Gln Phe Val Phe Cys His Tyr Val Val Ser 
            420                 425                 430         


Arg Asp Pro Thr Ala Phe Ser Glu Pro Glu Ser Phe Gln Pro His Arg 
        435                 440                 445             


Trp Leu Arg Asn Ser Gln Pro Ala Thr Pro Arg Ile Gln His Pro Phe 
    450                 455                 460                 


Gly Ser Val Pro Phe Gly Tyr Gly Val Arg Ala Cys Leu Gly Arg Arg 
465                 470                 475                 480 


Ile Ala Glu Leu Glu Met Gln Leu Leu Leu Ala Arg Leu Ile Gln Lys 
                485                 490                 495     


Tyr Lys Val Val Leu Ala Pro Glu Thr Gly Glu Leu Lys Ser Val Ala 
            500                 505                 510         


Arg Ile Val Leu Val Pro Asn Lys Lys Val Gly Leu Gln Phe Leu Gln 
        515                 520                 525             


Arg Gln Cys 
    530     


<210>  2811
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP27B1__Homo_sapiens__NP_000776

<400>  2811

Met Thr Gln Thr Leu Lys Tyr Ala Ser Arg Val Phe His Arg Val Arg 
1               5                   10                  15      


Trp Ala Pro Glu Leu Gly Ala Ser Leu Gly Tyr Arg Glu Tyr His Ser 
            20                  25                  30          


Ala Arg Arg Ser Leu Ala Asp Ile Pro Gly Pro Ser Thr Pro Ser Phe 
        35                  40                  45              


Leu Ala Glu Leu Phe Cys Lys Gly Gly Leu Ser Arg Leu His Glu Leu 
    50                  55                  60                  


Gln Val Gln Gly Ala Ala His Phe Gly Pro Val Trp Leu Ala Ser Phe 
65                  70                  75                  80  


Gly Thr Val Arg Thr Val Tyr Val Ala Ala Pro Ala Leu Val Glu Glu 
                85                  90                  95      


Leu Leu Arg Gln Glu Gly Pro Arg Pro Glu Arg Cys Ser Phe Ser Pro 
            100                 105                 110         


Trp Thr Glu His Arg Arg Cys Arg Gln Arg Ala Cys Gly Leu Leu Thr 
        115                 120                 125             


Ala Glu Gly Glu Glu Trp Gln Arg Leu Arg Ser Leu Leu Ala Pro Leu 
    130                 135                 140                 


Leu Leu Arg Pro Gln Ala Ala Ala Arg Tyr Ala Gly Thr Leu Asn Asn 
145                 150                 155                 160 


Val Val Cys Asp Leu Val Arg Arg Leu Arg Arg Gln Arg Gly Arg Gly 
                165                 170                 175     


Thr Gly Pro Pro Ala Leu Val Arg Asp Val Ala Gly Glu Phe Tyr Lys 
            180                 185                 190         


Phe Gly Leu Glu Gly Ile Ala Ala Val Leu Leu Gly Ser Arg Leu Gly 
        195                 200                 205             


Cys Leu Glu Ala Gln Val Pro Pro Asp Thr Glu Thr Phe Ile Arg Ala 
    210                 215                 220                 


Val Gly Ser Val Phe Val Ser Thr Leu Leu Thr Met Ala Met Pro His 
225                 230                 235                 240 


Trp Leu Arg His Leu Val Pro Gly Pro Trp Gly Arg Leu Cys Arg Asp 
                245                 250                 255     


Trp Asp Gln Met Phe Ala Phe Ala Gln Arg His Val Glu Arg Arg Glu 
            260                 265                 270         


Ala Glu Ala Ala Met Arg Asn Gly Gly Gln Pro Glu Lys Asp Leu Glu 
        275                 280                 285             


Ser Gly Ala His Leu Thr His Phe Leu Phe Arg Glu Glu Leu Pro Ala 
    290                 295                 300                 


Gln Ser Ile Leu Gly Asn Val Thr Glu Leu Leu Leu Ala Gly Val Asp 
305                 310                 315                 320 


Thr Val Ser Asn Thr Leu Ser Trp Ala Leu Tyr Glu Leu Ser Arg His 
                325                 330                 335     


Pro Glu Val Gln Thr Ala Leu His Ser Glu Ile Thr Ala Ala Leu Ser 
            340                 345                 350         


Pro Gly Ser Ser Ala Tyr Pro Ser Ala Thr Val Leu Ser Gln Leu Pro 
        355                 360                 365             


Leu Leu Lys Ala Val Val Lys Glu Val Leu Arg Leu Tyr Pro Val Val 
    370                 375                 380                 


Pro Gly Asn Ser Arg Val Pro Asp Lys Asp Ile His Val Gly Asp Tyr 
385                 390                 395                 400 


Ile Ile Pro Lys Asn Thr Leu Val Thr Leu Cys His Tyr Ala Thr Ser 
                405                 410                 415     


Arg Asp Pro Ala Gln Phe Pro Glu Pro Asn Ser Phe Arg Pro Ala Arg 
            420                 425                 430         


Trp Leu Gly Glu Gly Pro Thr Pro His Pro Phe Ala Ser Leu Pro Phe 
        435                 440                 445             


Gly Phe Gly Lys Arg Ser Cys Met Gly Arg Arg Leu Ala Glu Leu Glu 
    450                 455                 460                 


Leu Gln Met Ala Leu Ala Gln Ile Leu Thr His Phe Glu Val Gln Pro 
465                 470                 475                 480 


Glu Pro Gly Ala Ala Pro Val Arg Pro Lys Thr Arg Thr Val Leu Val 
                485                 490                 495     


Pro Glu Arg Ser Ile Asn Leu Gln Phe Leu Asp Arg 
            500                 505             


<210>  2812
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP27C1__Homo_sapiens__NP_001001665

<400>  2812

Met Arg Ser Val Leu Arg Gln Arg Ile Leu Lys Pro Lys Asp Val Ala 
1               5                   10                  15      


Ile Tyr Ser Gly Glu Val Asn Gln Val Ile Ala Asp Leu Ile Lys Arg 
            20                  25                  30          


Ile Tyr Leu Leu Arg Ser Gln Ala Glu Asp Gly Glu Thr Val Thr Asn 
        35                  40                  45              


Val Asn Asp Leu Phe Phe Lys Tyr Ser Met Glu Gly Val Ala Thr Ile 
    50                  55                  60                  


Leu Tyr Glu Ser Arg Leu Gly Cys Leu Glu Asn Ser Ile Pro Gln Leu 
65                  70                  75                  80  


Thr Val Glu Tyr Ile Glu Ala Leu Glu Leu Met Phe Ser Met Phe Lys 
                85                  90                  95      


Thr Ser Met Tyr Ala Gly Ala Ile Pro Arg Trp Leu Arg Pro Phe Ile 
            100                 105                 110         


Pro Lys Pro Trp Arg Glu Phe Cys Arg Ser Trp Asp Gly Leu Phe Lys 
        115                 120                 125             


Phe Ser Gln Ile His Val Asp Asn Lys Leu Arg Asp Ile Gln Tyr Gln 
    130                 135                 140                 


Met Asp Arg Gly Arg Arg Val Ser Gly Gly Leu Leu Thr Tyr Leu Phe 
145                 150                 155                 160 


Leu Ser Gln Ala Leu Thr Leu Gln Glu Ile Tyr Ala Asn Val Thr Glu 
                165                 170                 175     


Met Leu Leu Ala Gly Val Asp Thr Thr Ser Phe Thr Leu Ser Trp Thr 
            180                 185                 190         


Val Tyr Leu Leu Ala Arg His Pro Glu Val Gln Gln Thr Val Tyr Arg 
        195                 200                 205             


Glu Ile Val Lys Asn Leu Gly Glu Arg His Val Pro Thr Ala Ala Asp 
    210                 215                 220                 


Val Pro Lys Val Pro Leu Val Arg Ala Leu Leu Lys Glu Thr Leu Arg 
225                 230                 235                 240 


Leu Phe Pro Val Leu Pro Gly Asn Gly Arg Val Thr Gln Glu Asp Leu 
                245                 250                 255     


Val Ile Gly Gly Tyr Leu Ile Pro Lys Gly Thr Gln Leu Ala Leu Cys 
            260                 265                 270         


His Tyr Ala Thr Ser Tyr Gln Asp Glu Asn Phe Pro Arg Ala Lys Glu 
        275                 280                 285             


Phe Arg Pro Glu Arg Trp Leu Arg Lys Gly Asp Leu Asp Arg Val Asp 
    290                 295                 300                 


Asn Phe Gly Ser Ile Pro Phe Gly His Gly Val Arg Ser Cys Ile Gly 
305                 310                 315                 320 


Arg Arg Ile Ala Glu Leu Glu Ile His Leu Val Val Ile Gln Leu Leu 
                325                 330                 335     


Gln His Phe Glu Ile Lys Thr Ser Ser Gln Thr Asn Ala Val His Ala 
            340                 345                 350         


Lys Thr His Gly Leu Leu Thr Pro Gly Gly Pro Ile His Val Arg Phe 
        355                 360                 365             


Val Asn Arg Lys 
    370         


<210>  2813
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2A13__Homo_sapiens__NP_000757

<400>  2813

Met Leu Ala Ser Gly Leu Leu Leu Val Thr Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Arg Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Lys Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Leu Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg 
        115                 120                 125             


Arg Phe Ser Ile Ala Thr Leu Arg Gly Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu 
145                 150                 155                 160 


Arg Gly Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Ser 
        195                 200                 205             


Phe Gln Phe Thr Ala Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Glu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Phe Ala Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Thr 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Met Leu Pro Met 
        355                 360                 365             


Gly Leu Ala His Arg Val Asn Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Arg Phe Phe Ser Asn Pro Arg Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asp Lys Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Tyr Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Ile Met Gln Asn Phe Arg Phe Lys Ser 
    450                 455                 460                 


Pro Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  2814
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2A6__Homo_sapiens__NP_000753

<400>  2814

Met Leu Ala Ser Gly Met Leu Leu Val Ala Leu Leu Val Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Lys Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu Gln Met Tyr Asn Ser Leu Met Lys Ile Ser Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Arg Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Val Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Val Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Arg 
        115                 120                 125             


Arg Phe Ser Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ala Gly Phe Leu Ile Asp Ala Leu 
145                 150                 155                 160 


Arg Gly Thr Gly Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Lys Asp Lys Glu Phe Leu Ser Leu Leu Arg Met Met Leu Gly Ile 
        195                 200                 205             


Phe Gln Phe Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Gln Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Arg Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile Arg Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Val Met Thr Thr Leu Asn Leu Phe Ile Gly Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Ala Lys Met Pro Tyr Met 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met 
        355                 360                 365             


Ser Leu Ala Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Tyr Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Ser Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asn Glu Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser 
    450                 455                 460                 


Ser Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Gly Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  2815
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2A7__Homo_sapiens__NP_000755

<400>  2815

Met Leu Ala Ser Gly Leu Leu Leu Val Ala Leu Leu Ala Cys Leu Thr 
1               5                   10                  15      


Val Met Val Leu Met Ser Val Trp Gln Gln Arg Lys Ser Arg Gly Lys 
            20                  25                  30          


Leu Pro Pro Gly Pro Thr Pro Leu Pro Phe Ile Gly Asn Tyr Leu Gln 
        35                  40                  45              


Leu Asn Thr Glu His Ile Cys Asp Ser Ile Met Lys Phe Ser Glu Cys 
    50                  55                  60                  


Tyr Gly Pro Val Phe Thr Ile His Leu Gly Pro Arg Arg Val Val Val 
65                  70                  75                  80  


Leu Cys Gly His Asp Ala Val Arg Glu Ala Leu Val Asp Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Glu Gln Ala Thr Phe Asp Trp Val Phe Lys 
            100                 105                 110         


Gly Tyr Gly Val Ala Phe Ser Asn Gly Glu Arg Ala Lys Gln Leu Leu 
        115                 120                 125             


Arg Phe Ala Ile Ala Thr Leu Arg Asp Phe Gly Val Gly Lys Arg Gly 
    130                 135                 140                 


Ile Glu Glu Arg Ile Gln Glu Glu Ser Gly Phe Leu Ile Glu Ala Ile 
145                 150                 155                 160 


Arg Ser Thr His Gly Ala Asn Ile Asp Pro Thr Phe Phe Leu Ser Arg 
                165                 170                 175     


Thr Val Ser Asn Val Ile Ser Ser Ile Val Phe Gly Asp Arg Phe Asp 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Leu Ser Leu Leu Ser Met Met Leu Gly Ile 
        195                 200                 205             


Phe Gln Phe Thr Ser Thr Ser Thr Gly Gln Leu Tyr Glu Met Phe Ser 
    210                 215                 220                 


Ser Val Met Lys His Leu Pro Gly Pro Gln Gln Gln Ala Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Gly Leu Glu Asp Phe Ile Ala Lys Lys Val Glu His Asn Gln 
                245                 250                 255     


Arg Thr Leu Asp Pro Asn Ser Pro Gln Asp Phe Ile Asp Ser Phe Leu 
            260                 265                 270         


Ile His Met Gln Glu Glu Glu Lys Asn Pro Asn Thr Glu Phe Tyr Leu 
        275                 280                 285             


Lys Asn Leu Met Met Ser Thr Leu Asn Leu Phe Ile Ala Gly Thr Glu 
    290                 295                 300                 


Thr Val Ser Thr Thr Leu Arg Tyr Gly Phe Leu Leu Leu Met Lys His 
305                 310                 315                 320 


Pro Glu Val Glu Ala Lys Val His Glu Glu Ile Asp Arg Val Ile Gly 
                325                 330                 335     


Lys Asn Arg Gln Pro Lys Phe Glu Asp Arg Thr Lys Met Pro Tyr Met 
            340                 345                 350         


Glu Ala Val Ile His Glu Ile Gln Arg Phe Gly Asp Val Ile Pro Met 
        355                 360                 365             


Ser Leu Ala Arg Arg Val Lys Lys Asp Thr Lys Phe Arg Asp Phe Phe 
    370                 375                 380                 


Leu Pro Lys Gly Thr Glu Val Phe Pro Met Leu Gly Ser Val Leu Arg 
385                 390                 395                 400 


Asp Pro Ser Phe Phe Ser Asn Pro Gln Asp Phe Asn Pro Gln His Phe 
                405                 410                 415     


Leu Asp Asp Lys Gly Gln Phe Lys Lys Ser Asp Ala Phe Val Pro Phe 
            420                 425                 430         


Ser Ile Gly Lys Arg Asn Cys Phe Gly Glu Gly Leu Ala Arg Met Glu 
        435                 440                 445             


Leu Phe Leu Phe Phe Thr Thr Val Met Gln Asn Phe Arg Leu Lys Ser 
    450                 455                 460                 


Ser Gln Ser Pro Lys Asp Ile Asp Val Ser Pro Lys His Val Val Phe 
465                 470                 475                 480 


Ala Thr Ile Pro Arg Asn Tyr Thr Met Ser Phe Leu Pro Arg 
                485                 490                 


<210>  2816
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2B6__Homo_sapiens__NP_000758

<400>  2816

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  2817
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2C18__Homo_sapiens__NP_000763

<400>  2817

Met Asp Pro Ala Val Ala Leu Val Leu Cys Leu Ser Cys Leu Phe Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Arg Leu Pro Ser Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Ile Leu Gln Leu Asp Val Lys 
        35                  40                  45              


Asp Met Ser Lys Ser Leu Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp His Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ser Phe Pro Val Ala Glu Lys Val Asn Lys Gly Leu Gly Ile 
            100                 105                 110         


Leu Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Cys Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Asn 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Ile Phe His Asp Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Arg Phe Leu Asn Leu Met Glu Lys Phe Asn Glu Asn Leu Arg Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Val Cys Asn Asn Phe Pro Ala Leu Ile Asp 
    210                 215                 220                 


Tyr Leu Pro Gly Ser His Asn Lys Ile Ala Glu Asn Phe Ala Tyr Ile 
225                 230                 235                 240 


Lys Ser Tyr Val Leu Glu Arg Ile Lys Glu His Gln Glu Ser Leu Asp 
                245                 250                 255     


Met Asn Ser Ala Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Gln Glu Lys His Asn Gln Gln Ser Glu Phe Thr Val Glu Ser Leu Ile 
        275                 280                 285             


Ala Thr Val Thr Asp Met Phe Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys Tyr Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Cys Val Val Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Ile Gln Arg Tyr Ile Asp Leu Leu Pro Thr Asn Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Val Lys Phe Lys Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Ile Thr Ser Leu Thr Ser Val Leu His Asn Asp Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro Gly His Phe Leu Asp Lys Ser 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Met Cys Met Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Gln Val Asp Pro 
    450                 455                 460                 


Lys Asp Ile Asp Ile Thr Pro Ile Ala Asn Ala Phe Gly Arg Val Pro 
465                 470                 475                 480 


Pro Leu Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  2818
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2C19__Homo_sapiens__NP_000760

<400>  2818

Met Asp Pro Phe Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Ile Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Asp Ile Lys 
        35                  40                  45              


Asp Val Ser Lys Ser Leu Thr Asn Leu Ser Lys Ile Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Glu Arg Met Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Val Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly His Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Arg Ile Val 
        195                 200                 205             


Ser Thr Pro Trp Ile Gln Ile Cys Asn Asn Phe Pro Thr Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Leu Ala Phe Met 
225                 230                 235                 240 


Glu Ser Asp Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Ile Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Lys Glu Lys Gln Asn Gln Gln Ser Glu Phe Thr Ile Glu Asn Leu Val 
        275                 280                 285             


Ile Thr Ala Ala Asp Leu Leu Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Gly His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Ile Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Val Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Thr Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro Arg His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asn Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Phe Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Ile Asp Pro 
    450                 455                 460                 


Lys Asp Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  2819
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2C8__Homo_sapiens__NP_000761

<400>  2819

Met Glu Pro Phe Val Val Leu Val Leu Cys Leu Ser Phe Met Leu Leu 
1               5                   10                  15      


Phe Ser Leu Trp Arg Gln Ser Cys Arg Arg Arg Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Ile Asp Val Lys 
        35                  40                  45              


Asp Ile Cys Lys Ser Phe Thr Asn Phe Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Val Tyr Phe Gly Met Asn Pro Ile Val Val Phe His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Asn Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Asn Ser Pro Ile Ser Gln Arg Ile Thr Lys Gly Leu Gly Ile 
            100                 105                 110         


Ile Ser Ser Asn Gly Lys Arg Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Thr Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala His Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Val Val Phe Gln Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Asn Phe Leu Thr Leu Met Lys Arg Phe Asn Glu Asn Phe Arg Ile Leu 
        195                 200                 205             


Asn Ser Pro Trp Ile Gln Val Cys Asn Asn Phe Pro Leu Leu Ile Asp 
    210                 215                 220                 


Cys Phe Pro Gly Thr His Asn Lys Val Leu Lys Asn Val Ala Leu Thr 
225                 230                 235                 240 


Arg Ser Tyr Ile Arg Glu Lys Val Lys Glu His Gln Ala Ser Leu Asp 
                245                 250                 255     


Val Asn Asn Pro Arg Asp Phe Ile Asp Cys Phe Leu Ile Lys Met Glu 
            260                 265                 270         


Gln Glu Lys Asp Asn Gln Lys Ser Glu Phe Asn Ile Glu Asn Leu Val 
        275                 280                 285             


Gly Thr Val Ala Asp Leu Phe Val Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Gly Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Asp His Val Ile Gly Arg His Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Ile Gln Arg Tyr Ser Asp Leu Val Pro Thr Gly Val Pro His 
        355                 360                 365             


Ala Val Thr Thr Asp Thr Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Met Ala Leu Leu Thr Ser Val Leu His Asp Asp Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Asn Ile Phe Asp Pro Gly His Phe Leu Asp Lys Asn 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Asp Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Ala Gly Glu Gly Leu Ala Arg Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Thr Ile Leu Gln Asn Phe Asn Leu Lys Ser Val Asp Asp Leu 
    450                 455                 460                 


Lys Asn Leu Asn Thr Thr Ala Val Thr Lys Gly Ile Val Ser Leu Pro 
465                 470                 475                 480 


Pro Ser Tyr Gln Ile Cys Phe Ile Pro Val 
                485                 490 


<210>  2820
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2C9__Homo_sapiens__NP_000762

<400>  2820

Met Asp Ser Leu Val Val Leu Val Leu Cys Leu Ser Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Trp Arg Gln Ser Ser Gly Arg Gly Lys Leu Pro Pro Gly 
            20                  25                  30          


Pro Thr Pro Leu Pro Val Ile Gly Asn Ile Leu Gln Ile Gly Ile Lys 
        35                  40                  45              


Asp Ile Ser Lys Ser Leu Thr Asn Leu Ser Lys Val Tyr Gly Pro Val 
    50                  55                  60                  


Phe Thr Leu Tyr Phe Gly Leu Lys Pro Ile Val Val Leu His Gly Tyr 
65                  70                  75                  80  


Glu Ala Val Lys Glu Ala Leu Ile Asp Leu Gly Glu Glu Phe Ser Gly 
                85                  90                  95      


Arg Gly Ile Phe Pro Leu Ala Glu Arg Ala Asn Arg Gly Phe Gly Ile 
            100                 105                 110         


Val Phe Ser Asn Gly Lys Lys Trp Lys Glu Ile Arg Arg Phe Ser Leu 
        115                 120                 125             


Met Thr Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Asp Arg 
    130                 135                 140                 


Val Gln Glu Glu Ala Arg Cys Leu Val Glu Glu Leu Arg Lys Thr Lys 
145                 150                 155                 160 


Ala Ser Pro Cys Asp Pro Thr Phe Ile Leu Gly Cys Ala Pro Cys Asn 
                165                 170                 175     


Val Ile Cys Ser Ile Ile Phe His Lys Arg Phe Asp Tyr Lys Asp Gln 
            180                 185                 190         


Gln Phe Leu Asn Leu Met Glu Lys Leu Asn Glu Asn Ile Lys Ile Leu 
        195                 200                 205             


Ser Ser Pro Trp Ile Gln Ile Cys Asn Asn Phe Ser Pro Ile Ile Asp 
    210                 215                 220                 


Tyr Phe Pro Gly Thr His Asn Lys Leu Leu Lys Asn Val Ala Phe Met 
225                 230                 235                 240 


Lys Ser Tyr Ile Leu Glu Lys Val Lys Glu His Gln Glu Ser Met Asp 
                245                 250                 255     


Met Asn Asn Pro Gln Asp Phe Ile Asp Cys Phe Leu Met Lys Met Glu 
            260                 265                 270         


Lys Glu Lys His Asn Gln Pro Ser Glu Phe Thr Ile Glu Ser Leu Glu 
        275                 280                 285             


Asn Thr Ala Val Asp Leu Phe Gly Ala Gly Thr Glu Thr Thr Ser Thr 
    290                 295                 300                 


Thr Leu Arg Tyr Ala Leu Leu Leu Leu Leu Lys His Pro Glu Val Thr 
305                 310                 315                 320 


Ala Lys Val Gln Glu Glu Ile Glu Arg Val Ile Gly Arg Asn Arg Ser 
                325                 330                 335     


Pro Cys Met Gln Asp Arg Ser His Met Pro Tyr Thr Asp Ala Val Val 
            340                 345                 350         


His Glu Val Gln Arg Tyr Ile Asp Leu Leu Pro Thr Ser Leu Pro His 
        355                 360                 365             


Ala Val Thr Cys Asp Ile Lys Phe Arg Asn Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Thr Ile Leu Ile Ser Leu Thr Ser Val Leu His Asp Asn Lys Glu 
385                 390                 395                 400 


Phe Pro Asn Pro Glu Met Phe Asp Pro His His Phe Leu Asp Glu Gly 
                405                 410                 415     


Gly Asn Phe Lys Lys Ser Lys Tyr Phe Met Pro Phe Ser Ala Gly Lys 
            420                 425                 430         


Arg Ile Cys Val Gly Glu Ala Leu Ala Gly Met Glu Leu Phe Leu Phe 
        435                 440                 445             


Leu Thr Ser Ile Leu Gln Asn Phe Asn Leu Lys Ser Leu Val Asp Pro 
    450                 455                 460                 


Lys Asn Leu Asp Thr Thr Pro Val Val Asn Gly Phe Ala Ser Val Pro 
465                 470                 475                 480 


Pro Phe Tyr Gln Leu Cys Phe Ile Pro Val 
                485                 490 


<210>  2821
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2D6__Homo_sapiens__NP_000097

<400>  2821

Met Gly Leu Glu Ala Leu Val Pro Leu Ala Val Ile Val Ala Ile Phe 
1               5                   10                  15      


Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp Ala Ala Arg 
            20                  25                  30          


Tyr Pro Pro Gly Pro Leu Pro Leu Pro Gly Leu Gly Asn Leu Leu His 
        35                  40                  45              


Val Asp Phe Gln Asn Thr Pro Tyr Cys Phe Asp Gln Leu Arg Arg Arg 
    50                  55                  60                  


Phe Gly Asp Val Phe Ser Leu Gln Leu Ala Trp Thr Pro Val Val Val 
65                  70                  75                  80  


Leu Asn Gly Leu Ala Ala Val Arg Glu Ala Leu Val Thr His Gly Glu 
                85                  90                  95      


Asp Thr Ala Asp Arg Pro Pro Val Pro Ile Thr Gln Ile Leu Gly Phe 
            100                 105                 110         


Gly Pro Arg Ser Gln Gly Val Phe Leu Ala Arg Tyr Gly Pro Ala Trp 
        115                 120                 125             


Arg Glu Gln Arg Arg Phe Ser Val Ser Thr Leu Arg Asn Leu Gly Leu 
    130                 135                 140                 


Gly Lys Lys Ser Leu Glu Gln Trp Val Thr Glu Glu Ala Ala Cys Leu 
145                 150                 155                 160 


Cys Ala Ala Phe Ala Asn His Ser Gly Arg Pro Phe Arg Pro Asn Gly 
                165                 170                 175     


Leu Leu Asp Lys Ala Val Ser Asn Val Ile Ala Ser Leu Thr Cys Gly 
            180                 185                 190         


Arg Arg Phe Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu 
        195                 200                 205             


Ala Gln Glu Gly Leu Lys Glu Glu Ser Gly Phe Leu Arg Glu Val Leu 
    210                 215                 220                 


Asn Ala Val Pro Val Leu Leu His Ile Pro Ala Leu Ala Gly Lys Val 
225                 230                 235                 240 


Leu Arg Phe Gln Lys Ala Phe Leu Thr Gln Leu Asp Glu Leu Leu Thr 
                245                 250                 255     


Glu His Arg Met Thr Trp Asp Pro Ala Gln Pro Pro Arg Asp Leu Thr 
            260                 265                 270         


Glu Ala Phe Leu Ala Glu Met Glu Lys Ala Lys Gly Asn Pro Glu Ser 
        275                 280                 285             


Ser Phe Asn Asp Glu Asn Leu Arg Ile Val Val Ala Asp Leu Phe Ser 
    290                 295                 300                 


Ala Gly Met Val Thr Thr Ser Thr Thr Leu Ala Trp Gly Leu Leu Leu 
305                 310                 315                 320 


Met Ile Leu His Pro Asp Val Gln Arg Arg Val Gln Gln Glu Ile Asp 
                325                 330                 335     


Asp Val Ile Gly Gln Val Arg Arg Pro Glu Met Gly Asp Gln Ala His 
            340                 345                 350         


Met Pro Tyr Thr Thr Ala Val Ile His Glu Val Gln Arg Phe Gly Asp 
        355                 360                 365             


Ile Val Pro Leu Gly Val Thr His Met Thr Ser Arg Asp Ile Glu Val 
    370                 375                 380                 


Gln Gly Phe Arg Ile Pro Lys Gly Thr Thr Leu Ile Thr Asn Leu Ser 
385                 390                 395                 400 


Ser Val Leu Lys Asp Glu Ala Val Trp Glu Lys Pro Phe Arg Phe His 
                405                 410                 415     


Pro Glu His Phe Leu Asp Ala Gln Gly His Phe Val Lys Pro Glu Ala 
            420                 425                 430         


Phe Leu Pro Phe Ser Ala Gly Arg Arg Ala Cys Leu Gly Glu Pro Leu 
        435                 440                 445             


Ala Arg Met Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe 
    450                 455                 460                 


Ser Phe Ser Val Pro Thr Gly Gln Pro Arg Pro Ser His His Gly Val 
465                 470                 475                 480 


Phe Ala Phe Leu Val Ser Pro Ser Pro Tyr Glu Leu Cys Ala Val Pro 
                485                 490                 495     


Arg 
    


<210>  2822
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2E1__Homo_sapiens__NP_000764

<400>  2822

Met Ser Ala Leu Gly Val Thr Val Ala Leu Leu Val Trp Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Val Ser Met Trp Arg Gln Val His Ser Ser Trp Asn Leu 
            20                  25                  30          


Pro Pro Gly Pro Phe Pro Leu Pro Ile Ile Gly Asn Leu Phe Gln Leu 
        35                  40                  45              


Glu Leu Lys Asn Ile Pro Lys Ser Phe Thr Arg Leu Ala Gln Arg Phe 
    50                  55                  60                  


Gly Pro Val Phe Thr Leu Tyr Val Gly Ser Gln Arg Met Val Val Met 
65                  70                  75                  80  


His Gly Tyr Lys Ala Val Lys Glu Ala Leu Leu Asp Tyr Lys Asp Glu 
                85                  90                  95      


Phe Ser Gly Arg Gly Asp Leu Pro Ala Phe His Ala His Arg Asp Arg 
            100                 105                 110         


Gly Ile Ile Phe Asn Asn Gly Pro Thr Trp Lys Asp Ile Arg Arg Phe 
        115                 120                 125             


Ser Leu Thr Thr Leu Arg Asn Tyr Gly Met Gly Lys Gln Gly Asn Glu 
    130                 135                 140                 


Ser Arg Ile Gln Arg Glu Ala His Phe Leu Leu Glu Ala Leu Arg Lys 
145                 150                 155                 160 


Thr Gln Gly Gln Pro Phe Asp Pro Thr Phe Leu Ile Gly Cys Ala Pro 
                165                 170                 175     


Cys Asn Val Ile Ala Asp Ile Leu Phe Arg Lys His Phe Asp Tyr Asn 
            180                 185                 190         


Asp Glu Lys Phe Leu Arg Leu Met Tyr Leu Phe Asn Glu Asn Phe His 
        195                 200                 205             


Leu Leu Ser Thr Pro Trp Leu Gln Leu Tyr Asn Asn Phe Pro Ser Phe 
    210                 215                 220                 


Leu His Tyr Leu Pro Gly Ser His Arg Lys Val Ile Lys Asn Val Ala 
225                 230                 235                 240 


Glu Val Lys Glu Tyr Val Ser Glu Arg Val Lys Glu His His Gln Ser 
                245                 250                 255     


Leu Asp Pro Asn Cys Pro Arg Asp Leu Thr Asp Cys Leu Leu Val Glu 
            260                 265                 270         


Met Glu Lys Glu Lys His Ser Ala Glu Arg Leu Tyr Thr Met Asp Gly 
        275                 280                 285             


Ile Thr Val Thr Val Ala Asp Leu Phe Phe Ala Gly Thr Glu Thr Thr 
    290                 295                 300                 


Ser Thr Thr Leu Arg Tyr Gly Leu Leu Ile Leu Met Lys Tyr Pro Glu 
305                 310                 315                 320 


Ile Glu Glu Lys Leu His Glu Glu Ile Asp Arg Val Ile Gly Pro Ser 
                325                 330                 335     


Arg Ile Pro Ala Ile Lys Asp Arg Gln Glu Met Pro Tyr Met Asp Ala 
            340                 345                 350         


Val Val His Glu Ile Gln Arg Phe Ile Thr Leu Val Pro Ser Asn Leu 
        355                 360                 365             


Pro His Glu Ala Thr Arg Asp Thr Ile Phe Arg Gly Tyr Leu Ile Pro 
    370                 375                 380                 


Lys Gly Thr Val Val Val Pro Thr Leu Asp Ser Val Leu Tyr Asp Asn 
385                 390                 395                 400 


Gln Glu Phe Pro Asp Pro Glu Lys Phe Lys Pro Glu His Phe Leu Asn 
                405                 410                 415     


Glu Asn Gly Lys Phe Lys Tyr Ser Asp Tyr Phe Lys Pro Phe Ser Thr 
            420                 425                 430         


Gly Lys Arg Val Cys Ala Gly Glu Gly Leu Ala Arg Met Glu Leu Phe 
        435                 440                 445             


Leu Leu Leu Cys Ala Ile Leu Gln His Phe Asn Leu Lys Pro Leu Val 
    450                 455                 460                 


Asp Pro Lys Asp Ile Asp Leu Ser Pro Ile His Ile Gly Phe Gly Cys 
465                 470                 475                 480 


Ile Pro Pro Arg Tyr Lys Leu Cys Val Ile Pro Arg Ser 
                485                 490             


<210>  2823
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2F1__Homo_sapiens__NP_000765

<400>  2823

Met Asp Ser Ile Ser Thr Ala Ile Leu Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Cys Leu Leu Leu Thr Leu Ser Ser Arg Asp Lys Gly Lys Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Ser Ile Leu Gly Asn Leu Leu Leu Leu Cys Ser 
        35                  40                  45              


Gln Asp Met Leu Thr Ser Leu Thr Lys Leu Ser Lys Glu Tyr Gly Ser 
    50                  55                  60                  


Met Tyr Thr Val His Leu Gly Pro Arg Arg Val Val Val Leu Ser Gly 
65                  70                  75                  80  


Tyr Gln Ala Val Lys Glu Ala Leu Val Asp Gln Gly Glu Glu Phe Ser 
                85                  90                  95      


Gly Arg Gly Asp Tyr Pro Ala Phe Phe Asn Phe Thr Lys Gly Asn Gly 
            100                 105                 110         


Ile Ala Phe Ser Ser Gly Asp Arg Trp Lys Val Leu Arg Gln Phe Ser 
        115                 120                 125             


Ile Gln Ile Leu Arg Asn Phe Gly Met Gly Lys Arg Ser Ile Glu Glu 
    130                 135                 140                 


Arg Ile Leu Glu Glu Gly Ser Phe Leu Leu Ala Glu Leu Arg Lys Thr 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Asp Pro Thr Phe Val Leu Ser Arg Ser Val Ser 
                165                 170                 175     


Asn Ile Ile Cys Ser Val Leu Phe Gly Ser Arg Phe Asp Tyr Asp Asp 
            180                 185                 190         


Glu Arg Leu Leu Thr Ile Ile Arg Leu Ile Asn Asp Asn Phe Gln Ile 
        195                 200                 205             


Met Ser Ser Pro Trp Gly Glu Leu Tyr Asp Ile Phe Pro Ser Leu Leu 
    210                 215                 220                 


Asp Trp Val Pro Gly Pro His Gln Arg Ile Phe Gln Asn Phe Lys Cys 
225                 230                 235                 240 


Leu Arg Asp Leu Ile Ala His Ser Val His Asp His Gln Ala Ser Leu 
                245                 250                 255     


Asp Pro Arg Ser Pro Arg Asp Phe Ile Gln Cys Phe Leu Thr Lys Met 
            260                 265                 270         


Ala Glu Glu Lys Glu Asp Pro Leu Ser His Phe His Met Asp Thr Leu 
        275                 280                 285             


Leu Met Thr Thr His Asn Leu Leu Phe Gly Gly Thr Lys Thr Val Ser 
    290                 295                 300                 


Thr Thr Leu His His Ala Phe Leu Ala Leu Met Lys Tyr Pro Lys Val 
305                 310                 315                 320 


Gln Ala Arg Val Gln Glu Glu Ile Asp Leu Val Val Gly Arg Ala Arg 
                325                 330                 335     


Leu Pro Ala Leu Lys Asp Arg Ala Ala Met Pro Tyr Thr Asp Ala Val 
            340                 345                 350         


Ile His Glu Val Gln Arg Phe Ala Asp Ile Ile Pro Met Asn Leu Pro 
        355                 360                 365             


His Arg Val Thr Arg Asp Thr Ala Phe Arg Gly Phe Leu Ile Pro Lys 
    370                 375                 380                 


Gly Thr Asp Val Ile Thr Leu Leu Asn Thr Val His Tyr Asp Pro Ser 
385                 390                 395                 400 


Gln Phe Leu Thr Pro Gln Glu Phe Asn Pro Glu His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gln Ser Phe Lys Lys Ser Pro Ala Phe Met Pro Phe Ser Ala Gly 
            420                 425                 430         


Arg Arg Leu Cys Leu Gly Glu Ser Leu Ala Arg Met Glu Leu Phe Leu 
        435                 440                 445             


Tyr Leu Thr Ala Ile Leu Gln Ser Phe Ser Leu Gln Pro Leu Gly Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Leu Ser Ser Gly Leu Gly Asn Leu 
465                 470                 475                 480 


Pro Arg Pro Phe Gln Leu Cys Leu Arg Pro Arg 
                485                 490     


<210>  2824
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2R1__Homo_sapiens__NP_078790

<400>  2824

Met Trp Lys Leu Trp Arg Ala Glu Glu Gly Ala Ala Ala Leu Gly Gly 
1               5                   10                  15      


Ala Leu Phe Leu Leu Leu Phe Ala Leu Gly Val Arg Gln Leu Leu Lys 
            20                  25                  30          


Gln Arg Arg Pro Met Gly Phe Pro Pro Gly Pro Pro Gly Leu Pro Phe 
        35                  40                  45              


Ile Gly Asn Ile Tyr Ser Leu Ala Ala Ser Ser Glu Leu Pro His Val 
    50                  55                  60                  


Tyr Met Arg Lys Gln Ser Gln Val Tyr Gly Glu Ile Phe Ser Leu Asp 
65                  70                  75                  80  


Leu Gly Gly Ile Ser Thr Val Val Leu Asn Gly Tyr Asp Val Val Lys 
                85                  90                  95      


Glu Cys Leu Val His Gln Ser Glu Ile Phe Ala Asp Arg Pro Cys Leu 
            100                 105                 110         


Pro Leu Phe Met Lys Met Thr Lys Met Gly Gly Leu Leu Asn Ser Arg 
        115                 120                 125             


Tyr Gly Arg Gly Trp Val Asp His Arg Arg Leu Ala Val Asn Ser Phe 
    130                 135                 140                 


Arg Tyr Phe Gly Tyr Gly Gln Lys Ser Phe Glu Ser Lys Ile Leu Glu 
145                 150                 155                 160 


Glu Thr Lys Phe Phe Asn Asp Ala Ile Glu Thr Tyr Lys Gly Arg Pro 
                165                 170                 175     


Phe Asp Phe Lys Gln Leu Ile Thr Asn Ala Val Ser Asn Ile Thr Asn 
            180                 185                 190         


Leu Ile Ile Phe Gly Glu Arg Phe Thr Tyr Glu Asp Thr Asp Phe Gln 
        195                 200                 205             


His Met Ile Glu Leu Phe Ser Glu Asn Val Glu Leu Ala Ala Ser Ala 
    210                 215                 220                 


Ser Val Phe Leu Tyr Asn Ala Phe Pro Trp Ile Gly Ile Leu Pro Phe 
225                 230                 235                 240 


Gly Lys His Gln Gln Leu Phe Arg Asn Ala Ala Val Val Tyr Asp Phe 
                245                 250                 255     


Leu Ser Arg Leu Ile Glu Lys Ala Ser Val Asn Arg Lys Pro Gln Leu 
            260                 265                 270         


Pro Gln His Phe Val Asp Ala Tyr Leu Asp Glu Met Asp Gln Gly Lys 
        275                 280                 285             


Asn Asp Pro Ser Ser Thr Phe Ser Lys Glu Asn Leu Ile Phe Ser Val 
    290                 295                 300                 


Gly Glu Leu Ile Ile Ala Gly Thr Glu Thr Thr Thr Asn Val Leu Arg 
305                 310                 315                 320 


Trp Ala Ile Leu Phe Met Ala Leu Tyr Pro Asn Ile Gln Gly Gln Val 
                325                 330                 335     


Gln Lys Glu Ile Asp Leu Ile Met Gly Pro Asn Gly Lys Pro Ser Trp 
            340                 345                 350         


Asp Asp Lys Cys Lys Met Pro Tyr Thr Glu Ala Val Leu His Glu Val 
        355                 360                 365             


Leu Arg Phe Cys Asn Ile Val Pro Leu Gly Ile Phe His Ala Thr Ser 
    370                 375                 380                 


Glu Asp Ala Val Val Arg Gly Tyr Ser Ile Pro Lys Gly Thr Thr Val 
385                 390                 395                 400 


Ile Thr Asn Leu Tyr Ser Val His Phe Asp Glu Lys Tyr Trp Arg Asp 
                405                 410                 415     


Pro Glu Val Phe His Pro Glu Arg Phe Leu Asp Ser Ser Gly Tyr Phe 
            420                 425                 430         


Ala Lys Lys Glu Ala Leu Val Pro Phe Ser Leu Gly Arg Arg His Cys 
        435                 440                 445             


Leu Gly Glu His Leu Ala Arg Met Glu Met Phe Leu Phe Phe Thr Ala 
    450                 455                 460                 


Leu Leu Gln Arg Phe His Leu His Phe Pro His Glu Leu Val Pro Asp 
465                 470                 475                 480 


Leu Lys Pro Arg Leu Gly Met Thr Leu Gln Pro Gln Pro Tyr Leu Ile 
                485                 490                 495     


Cys Ala Glu Arg Arg 
            500     


<210>  2825
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2S1__Homo_sapiens__NP_085125

<400>  2825

Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly His Leu 
            20                  25                  30          


Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Leu 
        35                  40                  45              


Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Leu Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Pro Val Phe Thr Ile Tyr Leu Gly Pro Trp Arg Pro Val Val Val 
65                  70                  75                  80  


Leu Val Gly Gln Glu Ala Val Arg Glu Ala Leu Gly Gly Gln Ala Glu 
                85                  90                  95      


Glu Phe Ser Gly Arg Gly Thr Val Ala Met Leu Glu Gly Thr Phe Asp 
            100                 105                 110         


Gly His Gly Val Phe Phe Ser Asn Gly Glu Arg Trp Arg Gln Leu Arg 
        115                 120                 125             


Lys Phe Thr Met Leu Ala Leu Arg Asp Leu Gly Met Gly Lys Arg Glu 
    130                 135                 140                 


Gly Glu Glu Leu Ile Gln Ala Glu Ala Arg Cys Leu Val Glu Thr Phe 
145                 150                 155                 160 


Gln Gly Thr Glu Gly Arg Pro Phe Asp Pro Ser Leu Leu Leu Ala Gln 
                165                 170                 175     


Ala Thr Ser Asn Val Val Cys Ser Leu Leu Phe Gly Leu Arg Phe Ser 
            180                 185                 190         


Tyr Glu Asp Lys Glu Phe Gln Ala Val Val Arg Ala Ala Gly Gly Thr 
        195                 200                 205             


Leu Leu Gly Val Ser Ser Gln Gly Gly Gln Thr Tyr Glu Met Phe Ser 
    210                 215                 220                 


Trp Phe Leu Arg Pro Leu Pro Gly Pro His Lys Gln Leu Leu His His 
225                 230                 235                 240 


Val Ser Thr Leu Ala Ala Phe Thr Val Arg Gln Val Gln Gln His Gln 
                245                 250                 255     


Gly Asn Leu Asp Ala Ser Gly Pro Ala Arg Asp Leu Val Asp Ala Phe 
            260                 265                 270         


Leu Leu Lys Met Ala Gln Glu Glu Gln Asn Pro Gly Thr Glu Phe Thr 
        275                 280                 285             


Asn Lys Asn Met Leu Met Thr Val Ile Tyr Leu Leu Phe Ala Gly Thr 
    290                 295                 300                 


Met Thr Val Ser Thr Thr Val Gly Tyr Thr Leu Leu Leu Leu Met Lys 
305                 310                 315                 320 


Tyr Pro His Val Gln Lys Trp Val Arg Glu Glu Leu Asn Arg Glu Leu 
                325                 330                 335     


Gly Ala Gly Gln Ala Pro Ser Leu Gly Asp Arg Thr Arg Leu Pro Tyr 
            340                 345                 350         


Thr Asp Ala Val Leu His Glu Ala Gln Arg Leu Leu Ala Leu Val Pro 
        355                 360                 365             


Met Gly Ile Pro Arg Thr Leu Met Arg Thr Thr Arg Phe Arg Gly Tyr 
    370                 375                 380                 


Thr Leu Pro Gln Gly Thr Glu Val Phe Pro Leu Leu Gly Ser Ile Leu 
385                 390                 395                 400 


His Asp Pro Asn Ile Phe Lys His Pro Glu Glu Phe Asn Pro Asp Arg 
                405                 410                 415     


Phe Leu Asp Ala Asp Gly Arg Phe Arg Lys His Glu Ala Phe Leu Pro 
            420                 425                 430         


Phe Ser Leu Gly Lys Arg Val Cys Leu Gly Glu Gly Leu Ala Lys Ala 
        435                 440                 445             


Glu Leu Phe Leu Phe Phe Thr Thr Ile Leu Gln Ala Phe Ser Leu Glu 
    450                 455                 460                 


Ser Pro Cys Pro Pro Asp Thr Leu Ser Leu Lys Pro Thr Val Ser Gly 
465                 470                 475                 480 


Leu Phe Asn Ile Pro Pro Ala Phe Gln Leu Gln Val Arg Pro Thr Asp 
                485                 490                 495     


Leu His Ser Thr Thr Gln Thr Arg 
            500                 


<210>  2826
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2U1__Homo_sapiens__NP_898898

<400>  2826

Met Ser Ser Pro Gly Pro Ser Gln Pro Pro Ala Glu Asp Pro Pro Trp 
1               5                   10                  15      


Pro Ala Arg Leu Leu Arg Ala Pro Leu Gly Leu Leu Arg Leu Asp Pro 
            20                  25                  30          


Ser Gly Gly Ala Leu Leu Leu Cys Gly Leu Val Ala Leu Leu Gly Trp 
        35                  40                  45              


Ser Trp Leu Arg Arg Arg Arg Ala Arg Gly Ile Pro Pro Gly Pro Thr 
    50                  55                  60                  


Pro Trp Pro Leu Val Gly Asn Phe Gly His Val Leu Leu Pro Pro Phe 
65                  70                  75                  80  


Leu Arg Arg Arg Ser Trp Leu Ser Ser Arg Thr Arg Ala Ala Gly Ile 
                85                  90                  95      


Asp Pro Ser Val Ile Gly Pro Gln Val Leu Leu Ala His Leu Ala Arg 
            100                 105                 110         


Val Tyr Gly Ser Ile Phe Ser Phe Phe Ile Gly His Tyr Leu Val Val 
        115                 120                 125             


Val Leu Ser Asp Phe His Ser Val Arg Glu Ala Leu Val Gln Gln Ala 
    130                 135                 140                 


Glu Val Phe Ser Asp Arg Pro Arg Val Pro Leu Ile Ser Ile Val Thr 
145                 150                 155                 160 


Lys Glu Lys Gly Val Val Phe Ala His Tyr Gly Pro Val Trp Arg Gln 
                165                 170                 175     


Gln Arg Lys Phe Ser His Ser Thr Leu Arg His Phe Gly Leu Gly Lys 
            180                 185                 190         


Leu Ser Leu Glu Pro Lys Ile Ile Glu Glu Phe Lys Tyr Val Lys Ala 
        195                 200                 205             


Glu Met Gln Lys His Gly Glu Asp Pro Phe Cys Pro Phe Ser Ile Ile 
    210                 215                 220                 


Ser Asn Ala Val Ser Asn Ile Ile Cys Ser Leu Cys Phe Gly Gln Arg 
225                 230                 235                 240 


Phe Asp Tyr Thr Asn Ser Glu Phe Lys Lys Met Leu Gly Phe Met Ser 
                245                 250                 255     


Arg Gly Leu Glu Ile Cys Leu Asn Ser Gln Val Leu Leu Val Asn Ile 
            260                 265                 270         


Cys Pro Trp Leu Tyr Tyr Leu Pro Phe Gly Pro Phe Lys Glu Leu Arg 
        275                 280                 285             


Gln Ile Glu Lys Asp Ile Thr Ser Phe Leu Lys Lys Ile Ile Lys Asp 
    290                 295                 300                 


His Gln Glu Ser Leu Asp Arg Glu Asn Pro Gln Asp Phe Ile Asp Met 
305                 310                 315                 320 


Tyr Leu Leu His Met Glu Glu Glu Arg Lys Asn Asn Ser Asn Ser Ser 
                325                 330                 335     


Phe Asp Glu Glu Tyr Leu Phe Tyr Ile Ile Gly Asp Leu Phe Ile Ala 
            340                 345                 350         


Gly Thr Asp Thr Thr Thr Asn Ser Leu Leu Trp Cys Leu Leu Tyr Met 
        355                 360                 365             


Ser Leu Asn Pro Asp Val Gln Glu Lys Val His Glu Glu Ile Glu Arg 
    370                 375                 380                 


Val Ile Gly Ala Asn Arg Ala Pro Ser Leu Thr Asp Lys Ala Gln Met 
385                 390                 395                 400 


Pro Tyr Thr Glu Ala Thr Ile Met Glu Val Gln Arg Leu Thr Val Val 
                405                 410                 415     


Val Pro Leu Ala Ile Pro His Met Thr Ser Glu Asn Thr Val Leu Gln 
            420                 425                 430         


Gly Tyr Thr Ile Pro Lys Gly Thr Leu Ile Leu Pro Asn Leu Trp Ser 
        435                 440                 445             


Val His Arg Asp Pro Ala Ile Trp Glu Lys Pro Glu Asp Phe Tyr Pro 
    450                 455                 460                 


Asn Arg Phe Leu Asp Asp Gln Gly Gln Leu Ile Lys Lys Glu Thr Phe 
465                 470                 475                 480 


Ile Pro Phe Gly Ile Gly Lys Arg Val Cys Met Gly Glu Gln Leu Ala 
                485                 490                 495     


Lys Met Glu Leu Phe Leu Met Phe Val Ser Leu Met Gln Ser Phe Ala 
            500                 505                 510         


Phe Ala Leu Pro Glu Asp Ser Lys Lys Pro Leu Leu Thr Gly Arg Phe 
        515                 520                 525             


Gly Leu Thr Leu Ala Pro His Pro Phe Asn Ile Thr Ile Ser Arg Arg 
    530                 535                 540                 


<210>  2827
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP2W1__Homo_sapiens__NP_060251

<400>  2827

Met Ala Leu Leu Leu Leu Leu Phe Leu Gly Leu Leu Gly Leu Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ala Cys Ala Gln Asp Pro Ser Pro Ala Ala Arg Trp Pro 
            20                  25                  30          


Pro Gly Pro Arg Pro Leu Pro Leu Val Gly Asn Leu His Leu Leu Arg 
        35                  40                  45              


Leu Ser Gln Gln Asp Arg Ser Leu Met Glu Leu Ser Glu Arg Tyr Gly 
    50                  55                  60                  


Pro Val Phe Thr Val His Leu Gly Arg Gln Lys Thr Val Val Leu Thr 
65                  70                  75                  80  


Gly Phe Glu Ala Val Lys Glu Ala Leu Ala Gly Pro Gly Gln Glu Leu 
                85                  90                  95      


Ala Asp Arg Pro Pro Ile Ala Ile Phe Gln Leu Ile Gln Arg Gly Gly 
            100                 105                 110         


Gly Ile Phe Phe Ser Ser Gly Ala Arg Trp Arg Ala Ala Arg Gln Phe 
        115                 120                 125             


Thr Val Arg Ala Leu His Ser Leu Gly Val Gly Arg Glu Pro Val Ala 
    130                 135                 140                 


Asp Lys Ile Leu Gln Glu Leu Lys Cys Leu Ser Gly Gln Leu Asp Gly 
145                 150                 155                 160 


Tyr Arg Gly Arg Pro Phe Pro Leu Ala Leu Leu Gly Trp Ala Pro Ser 
                165                 170                 175     


Asn Ile Thr Phe Ala Leu Leu Phe Gly Arg Arg Phe Asp Tyr Arg Asp 
            180                 185                 190         


Pro Val Phe Val Ser Leu Leu Gly Leu Ile Asp Glu Val Met Val Leu 
        195                 200                 205             


Leu Gly Ser Pro Gly Leu Gln Leu Phe Asn Val Tyr Pro Trp Leu Gly 
    210                 215                 220                 


Ala Leu Leu Gln Leu His Arg Pro Val Leu Arg Lys Ile Glu Glu Val 
225                 230                 235                 240 


Arg Ala Ile Leu Arg Thr Leu Leu Glu Ala Arg Arg Pro His Val Cys 
                245                 250                 255     


Pro Gly Asp Pro Val Cys Ser Tyr Val Asp Ala Leu Ile Gln Gln Gly 
            260                 265                 270         


Gln Gly Asp Asp Pro Glu Gly Leu Phe Ala Glu Ala Asn Ala Val Ala 
        275                 280                 285             


Cys Thr Leu Asp Met Val Met Ala Gly Thr Glu Thr Thr Ser Ala Thr 
    290                 295                 300                 


Leu Gln Trp Ala Ala Leu Leu Met Gly Arg His Pro Asp Val Gln Gly 
305                 310                 315                 320 


Arg Val Gln Glu Glu Leu Asp Arg Val Leu Gly Pro Gly Arg Thr Pro 
                325                 330                 335     


Arg Leu Glu Asp Gln Gln Ala Leu Pro Tyr Thr Ser Ala Val Leu His 
            340                 345                 350         


Glu Val Gln Arg Phe Ile Thr Leu Leu Pro His Val Pro Arg Cys Thr 
        355                 360                 365             


Ala Ala Asp Thr Gln Leu Gly Gly Phe Leu Leu Pro Lys Gly Thr Pro 
    370                 375                 380                 


Val Ile Pro Leu Leu Thr Ser Val Leu Leu Asp Glu Thr Gln Trp Gln 
385                 390                 395                 400 


Thr Pro Gly Gln Phe Asn Pro Gly His Phe Leu Asp Ala Asn Gly His 
                405                 410                 415     


Phe Val Lys Arg Glu Ala Phe Leu Pro Phe Ser Ala Gly Arg Arg Val 
            420                 425                 430         


Cys Val Gly Glu Arg Leu Ala Arg Thr Glu Leu Phe Leu Leu Phe Ala 
        435                 440                 445             


Gly Leu Leu Gln Arg Tyr Arg Leu Leu Pro Pro Pro Gly Val Ser Pro 
    450                 455                 460                 


Ala Ser Leu Asp Thr Thr Pro Ala Arg Ala Phe Thr Met Arg Pro Arg 
465                 470                 475                 480 


Ala Gln Ala Leu Cys Ala Val Pro Arg Pro 
                485                 490 


<210>  2828
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP39A1__Homo_sapiens__NP_057677

<400>  2828

Met Glu Leu Ile Ser Pro Thr Val Ile Ile Ile Leu Gly Cys Leu Ala 
1               5                   10                  15      


Leu Phe Leu Leu Leu Gln Arg Lys Asn Leu Arg Arg Pro Pro Cys Ile 
            20                  25                  30          


Lys Gly Trp Ile Pro Trp Ile Gly Val Gly Phe Glu Phe Gly Lys Ala 
        35                  40                  45              


Pro Leu Glu Phe Ile Glu Lys Ala Arg Ile Lys Tyr Gly Pro Ile Phe 
    50                  55                  60                  


Thr Val Phe Ala Met Gly Asn Arg Met Thr Phe Val Thr Glu Glu Glu 
65                  70                  75                  80  


Gly Ile Asn Val Phe Leu Lys Ser Lys Lys Val Asp Phe Glu Leu Ala 
                85                  90                  95      


Val Gln Asn Ile Val Tyr Arg Thr Ala Ser Ile Pro Lys Asn Val Phe 
            100                 105                 110         


Leu Ala Leu His Glu Lys Leu Tyr Ile Met Leu Lys Gly Lys Met Gly 
        115                 120                 125             


Thr Val Asn Leu His Gln Phe Thr Gly Gln Leu Thr Glu Glu Leu His 
    130                 135                 140                 


Glu Gln Leu Glu Asn Leu Gly Thr His Gly Thr Met Asp Leu Asn Asn 
145                 150                 155                 160 


Leu Val Arg His Leu Leu Tyr Pro Val Thr Val Asn Met Leu Phe Asn 
                165                 170                 175     


Lys Ser Leu Phe Ser Thr Asn Lys Lys Lys Ile Lys Glu Phe His Gln 
            180                 185                 190         


Tyr Phe Gln Val Tyr Asp Glu Asp Phe Glu Tyr Gly Ser Gln Leu Pro 
        195                 200                 205             


Glu Cys Leu Leu Arg Asn Trp Ser Lys Ser Lys Lys Trp Phe Leu Glu 
    210                 215                 220                 


Leu Phe Glu Lys Asn Ile Pro Asp Ile Lys Ala Cys Lys Ser Ala Lys 
225                 230                 235                 240 


Asp Asn Ser Met Thr Leu Leu Gln Ala Thr Leu Asp Ile Val Glu Thr 
                245                 250                 255     


Glu Thr Ser Lys Glu Asn Ser Pro Asn Tyr Gly Leu Leu Leu Leu Trp 
            260                 265                 270         


Ala Ser Leu Ser Asn Ala Val Pro Val Ala Phe Trp Thr Leu Ala Tyr 
        275                 280                 285             


Val Leu Ser His Pro Asp Ile His Lys Ala Ile Met Glu Gly Ile Ser 
    290                 295                 300                 


Ser Val Phe Gly Lys Ala Gly Lys Asp Lys Ile Lys Val Ser Glu Asp 
305                 310                 315                 320 


Asp Leu Glu Asn Leu Leu Leu Ile Lys Trp Cys Val Leu Glu Thr Ile 
                325                 330                 335     


Arg Leu Lys Ala Pro Gly Val Ile Thr Arg Lys Val Val Lys Pro Val 
            340                 345                 350         


Glu Ile Leu Asn Tyr Ile Ile Pro Ser Gly Asp Leu Leu Met Leu Ser 
        355                 360                 365             


Pro Phe Trp Leu His Arg Asn Pro Lys Tyr Phe Pro Glu Pro Glu Leu 
    370                 375                 380                 


Phe Lys Pro Glu Arg Trp Lys Lys Ala Asn Leu Glu Lys His Ser Phe 
385                 390                 395                 400 


Leu Asp Cys Phe Met Ala Phe Gly Ser Gly Lys Phe Gln Cys Pro Ala 
                405                 410                 415     


Arg Trp Phe Ala Leu Leu Glu Val Gln Met Cys Ile Ile Leu Ile Leu 
            420                 425                 430         


Tyr Lys Tyr Asp Cys Ser Leu Leu Asp Pro Leu Pro Lys Gln Ser Tyr 
        435                 440                 445             


Leu His Leu Val Gly Val Pro Gln Pro Glu Gly Gln Cys Arg Ile Glu 
    450                 455                 460                 


Tyr Lys Gln Arg Ile 
465                 


<210>  2829
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP3A43__Homo_sapiens__NP_001265850

<400>  2829

Met Asp Leu Ile Pro Asn Phe Ala Met Glu Thr Trp Val Leu Val Ala 
1               5                   10                  15      


Thr Ser Leu Val Leu Leu Tyr Ile Tyr Gly Thr His Ser His Lys Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Thr Ile Leu Phe Tyr Leu Arg Arg Ser Leu Asn Lys Ile Pro Ser Trp 
    50                  55                  60                  


Ala Trp Trp Leu Thr Pro Val Ile Pro Ala Leu Trp Glu Ala Glu Ala 
65                  70                  75                  80  


Gly Gly Ser Pro Lys Val Arg Ser Ser Arg Pro Ala Leu Pro Thr Trp 
                85                  90                  95      


Val Phe Gly Ile Leu Thr Glu Asn Val Met Lys Asn Thr Glu Lys Cys 
            100                 105                 110         


Gly Ala Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Ile 
        115                 120                 125             


Gly Leu Phe Pro Lys Asp Val Thr His Phe Leu Lys Asn Ser Ile Glu 
    130                 135                 140                 


Arg Met Lys Glu Ser Arg Leu Lys Asp Lys Gln Lys His Arg Val Asp 
145                 150                 155                 160 


Phe Phe Gln Gln Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Lys Ser 
                165                 170                 175     


His Lys Ala Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Ile 
            180                 185                 190         


Ile Phe Ala Ala Tyr Asp Thr Thr Ser Thr Thr Leu Pro Phe Ile Met 
        195                 200                 205             


Tyr Glu Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu 
    210                 215                 220                 


Ile Asp Ala Val Leu Pro Asn Lys Ala Pro Val Thr Tyr Asp Ala Leu 
225                 230                 235                 240 


Val Gln Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu 
                245                 250                 255     


Phe Pro Val Val Ser Arg Val Thr Arg Val Cys Lys Lys Asp Ile Glu 
            260                 265                 270         


Ile Asn Gly Val Phe Ile Pro Lys Gly Leu Ala Val Met Val Pro Ile 
        275                 280                 285             


Tyr Ala Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe 
    290                 295                 300                 


Cys Pro Glu Arg Phe Ser Lys Lys Asn Lys Asp Ser Ile Asp Leu Tyr 
305                 310                 315                 320 


Arg Tyr Ile Pro Phe Gly Ala Gly Pro Arg Asn Cys Ile Gly Met Arg 
                325                 330                 335     


Phe Ala Leu Thr Asn Ile Lys Leu Ala Val Ile Arg Ala Leu Gln Asn 
            340                 345                 350         


Phe Ser Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp 
        355                 360                 365             


Asn Leu Pro Ile Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val His 
    370                 375                 380                 


Leu Arg Asp Gly Ile Thr Ser Gly Pro 
385                 390             


<210>  2830
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP3A4__Homo_sapiens__NP_001189784

<400>  2830

Met Ala Leu Ile Pro Asp Leu Ala Met Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr His Ser His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ile Leu Ser Tyr His Lys Gly Phe Cys Met Phe Asp Met Glu Cys 
    50                  55                  60                  


His Lys Lys Tyr Gly Lys Val Trp Gly Phe Tyr Asp Gly Gln Gln Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Leu Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys Asp Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asp Phe Leu Asp Pro Phe Phe Leu Ser Ile Ile 
    210                 215                 220                 


Phe Pro Phe Leu Ile Pro Ile Leu Glu Val Leu Asn Ile Cys Val Phe 
225                 230                 235                 240 


Pro Arg Glu Val Thr Asn Phe Leu Arg Lys Ser Val Lys Arg Met Lys 
                245                 250                 255     


Glu Ser Arg Leu Glu Asp Thr Gln Lys His Arg Val Asp Phe Leu Gln 
            260                 265                 270         


Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys Ala 
        275                 280                 285             


Leu Ser Asp Leu Glu Leu Val Ala Gln Ser Ile Ile Phe Ile Phe Ala 
    290                 295                 300                 


Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Met Tyr Glu Leu 
305                 310                 315                 320 


Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Glu Glu Ile Asp Ala 
                325                 330                 335     


Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln Met 
            340                 345                 350         


Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro Ile 
        355                 360                 365             


Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn Gly 
    370                 375                 380                 


Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Ala Leu 
385                 390                 395                 400 


His Arg Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro Glu 
                405                 410                 415     


Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr Thr 
            420                 425                 430         


Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala Leu 
        435                 440                 445             


Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser Phe 
    450                 455                 460                 


Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Ser Leu Gly Gly 
465                 470                 475                 480 


Leu Leu Gln Pro Glu Lys Pro Val Val Leu Lys Val Glu Ser Arg Asp 
                485                 490                 495     


Gly Thr Val Ser Gly Ala 
            500         


<210>  2831
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP3A5__Homo_sapiens__NP_000768

<400>  2831

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Val Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Arg Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly 
        35                  40                  45              


Asn Val Leu Ser Tyr Arg Gln Gly Leu Trp Lys Phe Asp Thr Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Gly Lys Met Trp Gly Thr Tyr Glu Gly Gln Leu Pro 
65                  70                  75                  80  


Val Leu Ala Ile Thr Asp Pro Asp Val Ile Arg Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Ser Leu Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Ser Ala Ile Ser Leu Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Phe Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Lys Gly Lys Pro Val Thr Leu Lys Asp Ile Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Gly Thr Ser Phe Gly Val Asn 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Ser Thr Lys 
        195                 200                 205             


Lys Phe Leu Lys Phe Gly Phe Leu Asp Pro Leu Phe Leu Ser Ile Ile 
    210                 215                 220                 


Leu Phe Pro Phe Leu Thr Pro Val Phe Glu Ala Leu Asn Val Ser Leu 
225                 230                 235                 240 


Phe Pro Lys Asp Thr Ile Asn Phe Leu Ser Lys Ser Val Asn Arg Met 
                245                 250                 255     


Lys Lys Ser Arg Leu Asn Asp Lys Gln Lys His Arg Leu Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Glu Thr Glu Ser His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Ala Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Thr Leu Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Leu Gln Lys Glu Ile Asp 
                325                 330                 335     


Ala Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Ala Val Val Gln 
            340                 345                 350         


Met Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Ile Arg Leu Glu Arg Thr Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Val Phe Ile Pro Lys Gly Ser Met Val Val Ile Pro Thr Tyr Ala 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Glu Phe Arg Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Lys Asp Ser Ile Asp Pro Tyr Ile Tyr Thr 
            420                 425                 430         


Pro Phe Gly Thr Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala Leu 
        435                 440                 445             


Met Asn Met Lys Leu Ala Leu Ile Arg Val Leu Gln Asn Phe Ser Phe 
    450                 455                 460                 


Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Asp Thr Gln Gly 
465                 470                 475                 480 


Leu Leu Gln Pro Glu Lys Pro Ile Val Leu Lys Val Asp Ser Arg Asp 
                485                 490                 495     


Gly Thr Leu Ser Gly Glu 
            500         


<210>  2832
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP3A7-CYP3A51P__Homo_sapiens__NP_001243426

<400>  2832

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Ile Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ala Leu Ser Phe Arg Lys Gly Tyr Trp Thr Phe Asp Met Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Arg Lys Val Trp Gly Ile Tyr Asp Cys Gln Gln Pro 
65                  70                  75                  80  


Met Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Asn Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys His Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Ser 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asn Pro Leu Asp Pro Phe Val Leu Ser Ile Lys 
    210                 215                 220                 


Val Phe Pro Phe Leu Thr Pro Ile Leu Glu Ala Leu Asn Ile Thr Val 
225                 230                 235                 240 


Phe Pro Arg Lys Val Ile Ser Phe Leu Thr Lys Ser Val Lys Gln Ile 
                245                 250                 255     


Lys Glu Gly Arg Leu Lys Glu Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Asp Ser Glu Thr His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Met Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Ile Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Val Gln Lys Glu Ile Asp 
                325                 330                 335     


Thr Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Leu Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Val 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Val Asn Met Lys Leu Ala Leu Val Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Arg Phe Gly 
465                 470                 475                 480 


Gly Leu Leu Leu Thr Glu Lys Pro Ile Val Leu Lys Ala Glu Ser Arg 
                485                 490                 495     


Asp Glu Thr Phe Val Asp Met Glu Pro Ile His Met Asp Phe Leu Arg 
            500                 505                 510         


Ser Leu Ala Phe Gln Gly Pro His Leu Cys Phe Phe Trp Glu Leu Leu 
        515                 520                 525             


Cys Pro Thr Ile Arg Ser Arg 
    530                 535 


<210>  2833
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP3A7__Homo_sapiens__NP_000756

<400>  2833

Met Asp Leu Ile Pro Asn Leu Ala Val Glu Thr Trp Leu Leu Leu Ala 
1               5                   10                  15      


Val Ser Leu Ile Leu Leu Tyr Leu Tyr Gly Thr Arg Thr His Gly Leu 
            20                  25                  30          


Phe Lys Lys Leu Gly Ile Pro Gly Pro Thr Pro Leu Pro Phe Leu Gly 
        35                  40                  45              


Asn Ala Leu Ser Phe Arg Lys Gly Tyr Trp Thr Phe Asp Met Glu Cys 
    50                  55                  60                  


Tyr Lys Lys Tyr Arg Lys Val Trp Gly Ile Tyr Asp Cys Gln Gln Pro 
65                  70                  75                  80  


Met Leu Ala Ile Thr Asp Pro Asp Met Ile Lys Thr Val Leu Val Lys 
                85                  90                  95      


Glu Cys Tyr Ser Val Phe Thr Asn Arg Arg Pro Phe Gly Pro Val Gly 
            100                 105                 110         


Phe Met Lys Asn Ala Ile Ser Ile Ala Glu Asp Glu Glu Trp Lys Arg 
        115                 120                 125             


Ile Arg Ser Leu Leu Ser Pro Thr Phe Thr Ser Gly Lys Leu Lys Glu 
    130                 135                 140                 


Met Val Pro Ile Ile Ala Gln Tyr Gly Asp Val Leu Val Arg Asn Leu 
145                 150                 155                 160 


Arg Arg Glu Ala Glu Thr Gly Lys Pro Val Thr Leu Lys His Val Phe 
                165                 170                 175     


Gly Ala Tyr Ser Met Asp Val Ile Thr Ser Thr Ser Phe Gly Val Ser 
            180                 185                 190         


Ile Asp Ser Leu Asn Asn Pro Gln Asp Pro Phe Val Glu Asn Thr Lys 
        195                 200                 205             


Lys Leu Leu Arg Phe Asn Pro Leu Asp Pro Phe Val Leu Ser Ile Lys 
    210                 215                 220                 


Val Phe Pro Phe Leu Thr Pro Ile Leu Glu Ala Leu Asn Ile Thr Val 
225                 230                 235                 240 


Phe Pro Arg Lys Val Ile Ser Phe Leu Thr Lys Ser Val Lys Gln Ile 
                245                 250                 255     


Lys Glu Gly Arg Leu Lys Glu Thr Gln Lys His Arg Val Asp Phe Leu 
            260                 265                 270         


Gln Leu Met Ile Asp Ser Gln Asn Ser Lys Asp Ser Glu Thr His Lys 
        275                 280                 285             


Ala Leu Ser Asp Leu Glu Leu Met Ala Gln Ser Ile Ile Phe Ile Phe 
    290                 295                 300                 


Ala Gly Tyr Glu Thr Thr Ser Ser Val Leu Ser Phe Ile Ile Tyr Glu 
305                 310                 315                 320 


Leu Ala Thr His Pro Asp Val Gln Gln Lys Val Gln Lys Glu Ile Asp 
                325                 330                 335     


Thr Val Leu Pro Asn Lys Ala Pro Pro Thr Tyr Asp Thr Val Leu Gln 
            340                 345                 350         


Leu Glu Tyr Leu Asp Met Val Val Asn Glu Thr Leu Arg Leu Phe Pro 
        355                 360                 365             


Val Ala Met Arg Leu Glu Arg Val Cys Lys Lys Asp Val Glu Ile Asn 
    370                 375                 380                 


Gly Met Phe Ile Pro Lys Gly Val Val Val Met Ile Pro Ser Tyr Val 
385                 390                 395                 400 


Leu His His Asp Pro Lys Tyr Trp Thr Glu Pro Glu Lys Phe Leu Pro 
                405                 410                 415     


Glu Arg Phe Ser Lys Lys Asn Lys Asp Asn Ile Asp Pro Tyr Ile Tyr 
            420                 425                 430         


Thr Pro Phe Gly Ser Gly Pro Arg Asn Cys Ile Gly Met Arg Phe Ala 
        435                 440                 445             


Leu Val Asn Met Lys Leu Ala Leu Val Arg Val Leu Gln Asn Phe Ser 
    450                 455                 460                 


Phe Lys Pro Cys Lys Glu Thr Gln Ile Pro Leu Lys Leu Arg Phe Gly 
465                 470                 475                 480 


Gly Leu Leu Leu Thr Glu Lys Pro Ile Val Leu Lys Ala Glu Ser Arg 
                485                 490                 495     


Asp Glu Thr Val Ser Gly Ala 
            500             


<210>  2834
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP46A1__Homo_sapiens__NP_006659

<400>  2834

Met Ser Pro Gly Leu Leu Leu Leu Gly Ser Ala Val Leu Leu Ala Phe 
1               5                   10                  15      


Gly Leu Cys Cys Thr Phe Val His Arg Ala Arg Ser Arg Tyr Glu His 
            20                  25                  30          


Ile Pro Gly Pro Pro Arg Pro Ser Phe Leu Leu Gly His Leu Pro Cys 
        35                  40                  45              


Phe Trp Lys Lys Asp Glu Val Gly Gly Arg Val Leu Gln Asp Val Phe 
    50                  55                  60                  


Leu Asp Trp Ala Lys Lys Tyr Gly Pro Val Val Arg Val Asn Val Phe 
65                  70                  75                  80  


His Lys Thr Ser Val Ile Val Thr Ser Pro Glu Ser Val Lys Lys Phe 
                85                  90                  95      


Leu Met Ser Thr Lys Tyr Asn Lys Asp Ser Lys Met Tyr Arg Ala Leu 
            100                 105                 110         


Gln Thr Val Phe Gly Glu Arg Leu Phe Gly Gln Gly Leu Val Ser Glu 
        115                 120                 125             


Cys Asn Tyr Glu Arg Trp His Lys Gln Arg Arg Val Ile Asp Leu Ala 
    130                 135                 140                 


Phe Ser Arg Ser Ser Leu Val Ser Leu Met Glu Thr Phe Asn Glu Lys 
145                 150                 155                 160 


Ala Glu Gln Leu Val Glu Ile Leu Glu Ala Lys Ala Asp Gly Gln Thr 
                165                 170                 175     


Pro Val Ser Met Gln Asp Met Leu Thr Tyr Thr Ala Met Asp Ile Leu 
            180                 185                 190         


Ala Lys Ala Ala Phe Gly Met Glu Thr Ser Met Leu Leu Gly Ala Gln 
        195                 200                 205             


Lys Pro Leu Ser Gln Ala Val Lys Leu Met Leu Glu Gly Ile Thr Ala 
    210                 215                 220                 


Ser Arg Asn Thr Leu Ala Lys Phe Leu Pro Gly Lys Arg Lys Gln Leu 
225                 230                 235                 240 


Arg Glu Val Arg Glu Ser Ile Arg Phe Leu Arg Gln Val Gly Arg Asp 
                245                 250                 255     


Trp Val Gln Arg Arg Arg Glu Ala Leu Lys Arg Gly Glu Glu Val Pro 
            260                 265                 270         


Ala Asp Ile Leu Thr Gln Ile Leu Lys Ala Glu Glu Gly Ala Gln Asp 
        275                 280                 285             


Asp Glu Gly Leu Leu Asp Asn Phe Val Thr Phe Phe Ile Ala Gly His 
    290                 295                 300                 


Glu Thr Ser Ala Asn His Leu Ala Phe Thr Val Met Glu Leu Ser Arg 
305                 310                 315                 320 


Gln Pro Glu Ile Val Ala Arg Leu Gln Ala Glu Val Asp Glu Val Ile 
                325                 330                 335     


Gly Ser Lys Arg Tyr Leu Asp Phe Glu Asp Leu Gly Arg Leu Gln Tyr 
            340                 345                 350         


Leu Ser Gln Val Leu Lys Glu Ser Leu Arg Leu Tyr Pro Pro Ala Trp 
        355                 360                 365             


Gly Thr Phe Arg Leu Leu Glu Glu Glu Thr Leu Ile Asp Gly Val Arg 
    370                 375                 380                 


Val Pro Gly Asn Thr Pro Leu Leu Phe Ser Thr Tyr Val Met Gly Arg 
385                 390                 395                 400 


Met Asp Thr Tyr Phe Glu Asp Pro Leu Thr Phe Asn Pro Asp Arg Phe 
                405                 410                 415     


Gly Pro Gly Ala Pro Lys Pro Arg Phe Thr Tyr Phe Pro Phe Ser Leu 
            420                 425                 430         


Gly His Arg Ser Cys Ile Gly Gln Gln Phe Ala Gln Met Glu Val Lys 
        435                 440                 445             


Val Val Met Ala Lys Leu Leu Gln Arg Leu Glu Phe Arg Leu Val Pro 
    450                 455                 460                 


Gly Gln Arg Phe Gly Leu Gln Glu Gln Ala Thr Leu Lys Pro Leu Asp 
465                 470                 475                 480 


Pro Val Leu Cys Thr Leu Arg Pro Arg Gly Trp Gln Pro Ala Pro Pro 
                485                 490                 495     


Pro Pro Pro Cys 
            500 


<210>  2835
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4A11__Homo_sapiens__XP_011539132

<400>  2835

Met Ser Val Ser Val Leu Ser Pro Ser Arg Leu Leu Gly Asp Val Ser 
1               5                   10                  15      


Gly Ile Leu Gln Ala Ala Ser Leu Leu Ile Leu Leu Leu Leu Leu Ile 
            20                  25                  30          


Lys Ala Val Gln Leu Tyr Leu His Arg Gln Trp Leu Leu Lys Ala Leu 
        35                  40                  45              


Gln Gln Phe Pro Cys Pro Pro Ser His Trp Leu Phe Gly His Ile Gln 
    50                  55                  60                  


Glu Leu Gln Gln Asp Gln Glu Leu Gln Arg Ile Gln Lys Trp Val Glu 
65                  70                  75                  80  


Thr Phe Pro Ser Ala Cys Pro His Trp Leu Trp Gly Gly Lys Val Arg 
                85                  90                  95      


Val Gln Leu Tyr Asp Pro Asp Tyr Met Lys Val Ile Leu Gly Arg Ser 
            100                 105                 110         


Ala Leu Ser Cys Leu Ser Asp Pro Lys Ser His Gly Ser Tyr Arg Phe 
        115                 120                 125             


Leu Ala Pro Trp Ile Gly Tyr Gly Leu Leu Leu Leu Asn Gly Gln Thr 
    130                 135                 140                 


Trp Phe Gln His Arg Arg Met Leu Thr Pro Ala Phe His Tyr Asp Ile 
145                 150                 155                 160 


Leu Lys Pro Tyr Val Gly Leu Met Ala Asp Ser Val Arg Val Met Leu 
                165                 170                 175     


Asp Lys Trp Glu Glu Leu Leu Gly Gln Asp Ser Pro Leu Glu Val Phe 
            180                 185                 190         


Gln His Val Ser Leu Met Thr Leu Asp Thr Ile Met Lys Cys Ala Phe 
        195                 200                 205             


Ser His Gln Gly Ser Ile Gln Val Asp Arg Pro Ser Asp Pro Thr Glu 
    210                 215                 220                 


Glu Gly Ser Thr Thr Glu Gly Gly Gly Ala Gly Glu Asp Gln Glu Glu 
225                 230                 235                 240 


Glu Ala Phe Gly Phe Ser Gly Tyr Pro Pro Leu Gly Gln Asn Gly Glu 
                245                 250                 255     


Trp Glu His Leu Val Arg Gln Gly Pro Pro Cys 
            260                 265         


<210>  2836
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4B1__Homo_sapiens__NP_001306090

<400>  2836

Met Val Pro Ser Phe Leu Ser Leu Ser Phe Ser Ser Leu Gly Leu Trp 
1               5                   10                  15      


Ala Ser Gly Leu Ile Leu Val Leu Gly Phe Leu Lys Leu Ile His Leu 
            20                  25                  30          


Leu Leu Arg Arg Gln Thr Leu Ala Lys Ala Met Asp Lys Phe Pro Gly 
        35                  40                  45              


Pro Pro Thr His Trp Leu Phe Gly His Ala Leu Glu Ile Gln Glu Thr 
    50                  55                  60                  


Gly Ser Leu Asp Lys Val Val Ser Trp Ala His Gln Phe Pro Tyr Ala 
65                  70                  75                  80  


His Pro Leu Trp Phe Gly Gln Phe Ile Gly Phe Leu Asn Ile Tyr Glu 
                85                  90                  95      


Pro Asp Tyr Ala Lys Ala Val Tyr Ser Arg Gly Gly Arg Gly Leu Leu 
            100                 105                 110         


Val Leu Glu Gly Pro Lys Trp Leu Gln His Arg Lys Leu Leu Thr Pro 
        115                 120                 125             


Gly Phe His Tyr Asp Val Leu Lys Pro Tyr Val Ala Val Phe Thr Glu 
    130                 135                 140                 


Ser Thr Arg Ile Met Leu Asp Lys Trp Glu Glu Lys Ala Arg Glu Gly 
145                 150                 155                 160 


Lys Ser Phe Asp Ile Phe Cys Asp Val Gly His Met Ala Leu Asn Thr 
                165                 170                 175     


Leu Met Lys Cys Thr Phe Gly Arg Gly Asp Thr Gly Leu Gly His Ser 
            180                 185                 190         


Arg Asp Ser Ser Tyr Tyr Leu Ala Val Ser Asp Leu Thr Leu Leu Met 
        195                 200                 205             


Gln Gln Arg Leu Val Ser Phe Gln Tyr His Asn Asp Phe Ile Tyr Trp 
    210                 215                 220                 


Leu Thr Pro His Gly Arg Arg Phe Leu Arg Ala Cys Gln Val Ala His 
225                 230                 235                 240 


Asp His Thr Asp Gln Val Ile Arg Glu Arg Lys Ala Ala Leu Gln Asp 
                245                 250                 255     


Glu Lys Val Arg Lys Lys Ile Gln Asn Arg Arg His Leu Asp Phe Leu 
            260                 265                 270         


Asp Ile Leu Leu Gly Ala Arg Asp Glu Asp Asp Ile Lys Leu Ser Asp 
        275                 280                 285             


Ala Asp Leu Arg Ala Glu Val Asp Thr Phe Met Phe Glu Gly His Asp 
    290                 295                 300                 


Thr Thr Thr Ser Gly Ile Ser Trp Phe Leu Tyr Cys Met Ala Leu Tyr 
305                 310                 315                 320 


Pro Glu His Gln His Arg Cys Arg Glu Glu Val Arg Glu Ile Leu Gly 
                325                 330                 335     


Asp Gln Asp Phe Phe Gln Trp Asp Asp Leu Gly Lys Met Thr Tyr Leu 
            340                 345                 350         


Thr Met Cys Ile Lys Glu Ser Phe Arg Leu Tyr Pro Pro Val Pro Gln 
        355                 360                 365             


Val Tyr Arg Gln Leu Ser Lys Pro Val Thr Phe Val Asp Gly Arg Ser 
    370                 375                 380                 


Leu Pro Ala Gly Ser Leu Ile Ser Met His Ile Tyr Ala Leu His Arg 
385                 390                 395                 400 


Asn Ser Ala Val Trp Pro Asp Pro Glu Val Phe Asp Ser Leu Arg Phe 
                405                 410                 415     


Ser Thr Glu Asn Ala Ser Lys Arg His Pro Phe Ala Phe Met Pro Phe 
            420                 425                 430         


Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Gln Phe Ala Met Ser Glu 
        435                 440                 445             


Met Lys Val Val Thr Ala Met Cys Leu Leu Arg Phe Glu Phe Ser Leu 
    450                 455                 460                 


Asp Pro Ser Arg Leu Pro Ile Lys Met Pro Gln Leu Val Leu Arg Ser 
465                 470                 475                 480 


Lys Asn Gly Phe His Leu His Leu Lys Pro Leu Gly Pro Gly Ser Gly 
                485                 490                 495     


Lys 
    


<210>  2837
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4F11__Homo_sapiens__NP_067010

<400>  2837

Met Pro Gln Leu Ser Leu Ser Trp Leu Gly Leu Gly Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Val Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Gln Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Met Lys Thr Leu Thr Gln Leu 
65                  70                  75                  80  


Val Thr Thr Tyr Pro Gln Gly Phe Lys Leu Trp Leu Gly Pro Thr Phe 
                85                  90                  95      


Pro Leu Leu Ile Leu Cys His Pro Asp Ile Ile Arg Pro Ile Thr Ser 
            100                 105                 110         


Ala Ser Ala Ala Val Ala Pro Lys Asp Met Ile Phe Tyr Gly Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Lys Ser Val Asn Ile Met His Asp 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Glu Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Phe Val Glu Lys Arg Asn Gln Gln Ile Leu 
225                 230                 235                 240 


Leu His Thr Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys His Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Cys Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Leu Lys 
        275                 280                 285             


Asn Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Gln Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Ile 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Phe Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Val Cys Leu Ile Asn Ile Ile Gly Ile His Tyr Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Gln Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu His Phe Arg Ile Leu Pro Thr His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Ile Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly Ala Asn Ser Gln 
        515                 520                 


<210>  2838
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4F12__Homo_sapiens__NP_076433

<400>  2838

Met Ser Leu Leu Ser Leu Pro Trp Leu Gly Leu Arg Pro Val Ala Thr 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu 
        35                  40                  45              


Gln Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu 
    50                  55                  60                  


Gly Leu Ile Thr Pro Thr Glu Glu Gly Leu Lys Asn Ser Thr Gln Met 
65                  70                  75                  80  


Ser Ala Thr Tyr Ser Gln Gly Phe Thr Val Trp Leu Gly Pro Ile Ile 
                85                  90                  95      


Pro Phe Ile Val Leu Cys His Pro Asp Thr Ile Arg Ser Ile Thr Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Asn Leu Phe Ile Arg Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Ser Tyr Ile Thr Ile Phe Asn Lys Ser Ala Asn Ile Met Leu Asp 
                165                 170                 175     


Lys Trp Gln His Leu Ala Ser Glu Gly Ser Ser Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Glu Lys Arg Ser Gln His Ile Leu 
225                 230                 235                 240 


Gln His Met Asp Phe Leu Tyr Tyr Leu Ser His Asp Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Arg 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Phe Lys 
        275                 280                 285             


Asp Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Ala Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Asp Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Val Lys Glu Ser Leu Arg Leu His Pro Pro Ala Pro Phe Ile Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Thr Cys Leu Ile Asp Ile Ile Gly Val His His Asn Pro Thr 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ser Lys Gly Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Met Leu Leu His Phe Arg Phe Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Leu Glu Leu Ile Met Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Asn Val Ser Leu Gln 
        515                 520                 


<210>  2839
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4F22__Homo_sapiens__NP_775754

<400>  2839

Met Leu Pro Ile Thr Asp Arg Leu Leu His Leu Leu Gly Leu Glu Lys 
1               5                   10                  15      


Thr Ala Phe Arg Ile Tyr Ala Val Ser Thr Leu Leu Leu Phe Leu Leu 
            20                  25                  30          


Phe Phe Leu Phe Arg Leu Leu Leu Arg Phe Leu Arg Leu Cys Arg Ser 
        35                  40                  45              


Phe Tyr Ile Thr Cys Arg Arg Leu Arg Cys Phe Pro Gln Pro Pro Arg 
    50                  55                  60                  


Arg Asn Trp Leu Leu Gly His Leu Gly Met Tyr Leu Pro Asn Glu Ala 
65                  70                  75                  80  


Gly Leu Gln Asp Glu Lys Lys Val Leu Asp Asn Met His His Val Leu 
                85                  90                  95      


Leu Val Trp Met Gly Pro Val Leu Pro Leu Leu Val Leu Val His Pro 
            100                 105                 110         


Asp Tyr Ile Lys Pro Leu Leu Gly Ala Ser Ala Ala Ile Ala Pro Lys 
        115                 120                 125             


Asp Asp Leu Phe Tyr Gly Phe Leu Lys Pro Trp Leu Gly Asp Gly Leu 
    130                 135                 140                 


Leu Leu Ser Lys Gly Asp Lys Trp Ser Arg His Arg Arg Leu Leu Thr 
145                 150                 155                 160 


Pro Ala Phe His Phe Asp Ile Leu Lys Pro Tyr Met Lys Ile Phe Asn 
                165                 170                 175     


Gln Ser Ala Asp Ile Met His Ala Lys Trp Arg His Leu Ala Glu Gly 
            180                 185                 190         


Ser Ala Val Ser Leu Asp Met Phe Glu His Ile Ser Leu Met Thr Leu 
        195                 200                 205             


Asp Ser Leu Gln Lys Cys Val Phe Ser Tyr Asn Ser Asn Cys Gln Glu 
    210                 215                 220                 


Lys Met Ser Asp Tyr Ile Ser Ala Ile Ile Glu Leu Ser Ala Leu Ser 
225                 230                 235                 240 


Val Arg Arg Gln Tyr Arg Leu His His Tyr Leu Asp Phe Ile Tyr Tyr 
                245                 250                 255     


Arg Ser Ala Asp Gly Arg Arg Phe Arg Gln Ala Cys Asp Met Val His 
            260                 265                 270         


His Phe Thr Thr Glu Val Ile Gln Glu Arg Arg Arg Ala Leu Arg Gln 
        275                 280                 285             


Gln Gly Ala Glu Ala Trp Leu Lys Ala Lys Gln Gly Lys Thr Leu Asp 
    290                 295                 300                 


Phe Ile Asp Val Leu Leu Leu Ala Arg Asp Glu Asp Gly Lys Glu Leu 
305                 310                 315                 320 


Ser Asp Glu Asp Ile Arg Ala Glu Ala Asp Thr Phe Met Phe Glu Gly 
                325                 330                 335     


His Asp Thr Thr Ser Ser Gly Ile Ser Trp Met Leu Phe Asn Leu Ala 
            340                 345                 350         


Lys Tyr Pro Glu Tyr Gln Glu Lys Cys Arg Glu Glu Ile Gln Glu Val 
        355                 360                 365             


Met Lys Gly Arg Glu Leu Glu Glu Leu Glu Trp Asp Asp Leu Thr Gln 
    370                 375                 380                 


Leu Pro Phe Thr Thr Met Cys Ile Lys Glu Ser Leu Arg Gln Tyr Pro 
385                 390                 395                 400 


Pro Val Thr Leu Val Ser Arg Gln Cys Thr Glu Asp Ile Lys Leu Pro 
                405                 410                 415     


Asp Gly Arg Ile Ile Pro Lys Gly Ile Ile Cys Leu Val Ser Ile Tyr 
            420                 425                 430         


Gly Thr His His Asn Pro Thr Val Trp Pro Asp Ser Lys Val Tyr Asn 
        435                 440                 445             


Pro Tyr Arg Phe Asp Pro Asp Asn Pro Gln Gln Arg Ser Pro Leu Ala 
    450                 455                 460                 


Tyr Val Pro Phe Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Ser Phe 
465                 470                 475                 480 


Ala Met Ala Glu Leu Arg Val Val Val Ala Leu Thr Leu Leu Arg Phe 
                485                 490                 495     


Arg Leu Ser Val Asp Arg Thr Arg Lys Val Arg Arg Lys Pro Glu Leu 
            500                 505                 510         


Ile Leu Arg Thr Glu Asn Gly Leu Trp Leu Lys Val Glu Pro Leu Pro 
        515                 520                 525             


Pro Arg Ala 
    530     


<210>  2840
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4F2__Homo_sapiens__NP_001073

<400>  2840

Met Ser Gln Leu Ser Leu Ser Trp Leu Gly Leu Trp Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


His Val Leu Ala Trp Thr Tyr Ala Phe Tyr Asp Asn Cys Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Arg Arg Asn Trp Phe Trp Gly His Gln 
    50                  55                  60                  


Gly Met Val Asn Pro Thr Glu Glu Gly Met Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Lys Val Trp Met Gly Pro Ile Ser 
                85                  90                  95      


Pro Leu Leu Ser Leu Cys His Pro Asp Ile Ile Arg Ser Val Ile Asn 
            100                 105                 110         


Ala Ser Ala Ala Ile Ala Pro Lys Asp Lys Phe Phe Tyr Ser Phe Leu 
        115                 120                 125             


Glu Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Asp Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Cys Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Ser Lys Arg His His Glu Ile Leu 
225                 230                 235                 240 


Leu His Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala His Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Met Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Val Ile Ser Arg 
385                 390                 395                 400 


His Val Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Thr Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  2841
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4F3__Homo_sapiens__NP_000887

<400>  2841

Met Pro Gln Leu Ser Leu Ser Ser Leu Gly Leu Trp Pro Met Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Cys Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Ile His Ser Ser Glu Glu Gly Leu Leu Tyr Thr Gln Ser Leu 
65                  70                  75                  80  


Ala Cys Thr Phe Gly Asp Met Cys Cys Trp Trp Val Gly Pro Trp His 
                85                  90                  95      


Ala Ile Val Arg Ile Phe His Pro Thr Tyr Ile Lys Pro Val Leu Phe 
            100                 105                 110         


Ala Pro Ala Ala Ile Val Pro Lys Asp Lys Val Phe Tyr Ser Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Glu Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Thr Lys Arg His Gln Gln Ile Leu 
225                 230                 235                 240 


Leu Tyr Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Ala Val Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Lys 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Gly Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210>  2842
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4F8__Homo_sapiens__NP_009184

<400>  2842

Met Ser Leu Leu Ser Leu Ser Trp Leu Gly Leu Arg Pro Val Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Val Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr His Asn Gly Arg Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Arg Lys Gln Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Val Thr Pro Thr Glu Glu Gly Leu Arg Val Leu Thr Gln Leu 
65                  70                  75                  80  


Val Ala Thr Tyr Pro Gln Gly Phe Val Arg Trp Leu Gly Pro Ile Thr 
                85                  90                  95      


Pro Ile Ile Asn Leu Cys His Pro Asp Ile Val Arg Ser Val Ile Asn 
            100                 105                 110         


Thr Ser Asp Ala Ile Thr Asp Lys Asp Ile Val Phe Tyr Lys Thr Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Val Gly Asp Lys Trp 
    130                 135                 140                 


Arg His His Arg Arg Leu Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Ile Lys Ile Phe Ser Lys Ser Ala Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Arg Leu Ala Met Glu Gly Ser Thr Cys Leu Asp Val Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe 
        195                 200                 205             


Ser Phe Asp Ser Asn Cys Gln Glu Lys Pro Ser Glu Tyr Ile Thr Ala 
    210                 215                 220                 


Ile Met Glu Leu Ser Ala Leu Val Val Lys Arg Asn Asn Gln Phe Phe 
225                 230                 235                 240 


Arg Tyr Lys Asp Phe Leu Tyr Phe Leu Thr Pro Cys Gly Arg Arg Phe 
                245                 250                 255     


His Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Thr Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Glu Asp Lys Asn Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Leu Lys Glu Ser Leu Arg Leu His Pro Pro Ile Pro Thr Phe Ala Arg 
385                 390                 395                 400 


Gly Cys Thr Gln Asp Val Val Leu Pro Asp Ser Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Asn Val Cys Asn Ile Asn Ile Phe Ala Ile His His Asn Pro Ser 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu 
        435                 440                 445             


Asn Ala Gln Lys Arg Ser Pro Met Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Lys Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Ala Leu Thr Leu Leu Arg Phe Arg Ile Leu Pro Asp His Arg 
                485                 490                 495     


Glu Pro Arg Arg Thr Pro Glu Ile Val Leu Arg Ala Glu Asp Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Gly 
        515                 520 


<210>  2843
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP4V2__Homo_sapiens__NP_997235

<400>  2843

Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Leu Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Gln Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
        515                 520                 525 


<210>  2844
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP51A1__Homo_sapiens__NP_000777

<400>  2844

Met Ala Ala Ala Ala Gly Met Leu Leu Leu Gly Leu Leu Gln Ala Gly 
1               5                   10                  15      


Gly Ser Val Leu Gly Gln Ala Met Glu Lys Val Thr Gly Gly Asn Leu 
            20                  25                  30          


Leu Ser Met Leu Leu Ile Ala Cys Ala Phe Thr Leu Ser Leu Val Tyr 
        35                  40                  45              


Leu Ile Arg Leu Ala Ala Gly His Leu Val Gln Leu Pro Ala Gly Val 
    50                  55                  60                  


Lys Ser Pro Pro Tyr Ile Phe Ser Pro Ile Pro Phe Leu Gly His Ala 
65                  70                  75                  80  


Ile Ala Phe Gly Lys Ser Pro Ile Glu Phe Leu Glu Asn Ala Tyr Glu 
                85                  90                  95      


Lys Tyr Gly Pro Val Phe Ser Phe Thr Met Val Gly Lys Thr Phe Thr 
            100                 105                 110         


Tyr Leu Leu Gly Ser Asp Ala Ala Ala Leu Leu Phe Asn Ser Lys Asn 
        115                 120                 125             


Glu Asp Leu Asn Ala Glu Asp Val Tyr Ser Arg Leu Thr Thr Pro Val 
    130                 135                 140                 


Phe Gly Lys Gly Val Ala Tyr Asp Val Pro Asn Pro Val Phe Leu Glu 
145                 150                 155                 160 


Gln Lys Lys Met Leu Lys Ser Gly Leu Asn Ile Ala His Phe Lys Gln 
                165                 170                 175     


His Val Ser Ile Ile Glu Lys Glu Thr Lys Glu Tyr Phe Glu Ser Trp 
            180                 185                 190         


Gly Glu Ser Gly Glu Lys Asn Val Phe Glu Ala Leu Ser Glu Leu Ile 
        195                 200                 205             


Ile Leu Thr Ala Ser His Cys Leu His Gly Lys Glu Ile Arg Ser Gln 
    210                 215                 220                 


Leu Asn Glu Lys Val Ala Gln Leu Tyr Ala Asp Leu Asp Gly Gly Phe 
225                 230                 235                 240 


Ser His Ala Ala Trp Leu Leu Pro Gly Trp Leu Pro Leu Pro Ser Phe 
                245                 250                 255     


Arg Arg Arg Asp Arg Ala His Arg Glu Ile Lys Asp Ile Phe Tyr Lys 
            260                 265                 270         


Ala Ile Gln Lys Arg Arg Gln Ser Gln Glu Lys Ile Asp Asp Ile Leu 
        275                 280                 285             


Gln Thr Leu Leu Asp Ala Thr Tyr Lys Asp Gly Arg Pro Leu Thr Asp 
    290                 295                 300                 


Asp Glu Val Ala Gly Met Leu Ile Gly Leu Leu Leu Ala Gly Gln His 
305                 310                 315                 320 


Thr Ser Ser Thr Thr Ser Ala Trp Met Gly Phe Phe Leu Ala Arg Asp 
                325                 330                 335     


Lys Thr Leu Gln Lys Lys Cys Tyr Leu Glu Gln Lys Thr Val Cys Gly 
            340                 345                 350         


Glu Asn Leu Pro Pro Leu Thr Tyr Asp Gln Leu Lys Asp Leu Asn Leu 
        355                 360                 365             


Leu Asp Arg Cys Ile Lys Glu Thr Leu Arg Leu Arg Pro Pro Ile Met 
    370                 375                 380                 


Ile Met Met Arg Met Ala Arg Thr Pro Gln Thr Val Ala Gly Tyr Thr 
385                 390                 395                 400 


Ile Pro Pro Gly His Gln Val Cys Val Ser Pro Thr Val Asn Gln Arg 
                405                 410                 415     


Leu Lys Asp Ser Trp Val Glu Arg Leu Asp Phe Asn Pro Asp Arg Tyr 
            420                 425                 430         


Leu Gln Asp Asn Pro Ala Ser Gly Glu Lys Phe Ala Tyr Val Pro Phe 
        435                 440                 445             


Gly Ala Gly Arg His Arg Cys Ile Gly Glu Asn Phe Ala Tyr Val Gln 
    450                 455                 460                 


Ile Lys Thr Ile Trp Ser Thr Met Leu Arg Leu Tyr Glu Phe Asp Leu 
465                 470                 475                 480 


Ile Asp Gly Tyr Phe Pro Thr Val Asn Tyr Thr Thr Met Ile His Thr 
                485                 490                 495     


Pro Glu Asn Pro Val Ile Arg Tyr Lys Arg Arg Ser Lys 
            500                 505                 


<210>  2845
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP7A1__Homo_sapiens__NP_000771

<400>  2845

Met Met Thr Thr Ser Leu Ile Trp Gly Ile Ala Ile Ala Ala Cys Cys 
1               5                   10                  15      


Cys Leu Trp Leu Ile Leu Gly Ile Arg Arg Arg Gln Thr Gly Glu Pro 
            20                  25                  30          


Pro Leu Glu Asn Gly Leu Ile Pro Tyr Leu Gly Cys Ala Leu Gln Phe 
        35                  40                  45              


Gly Ala Asn Pro Leu Glu Phe Leu Arg Ala Asn Gln Arg Lys His Gly 
    50                  55                  60                  


His Val Phe Thr Cys Lys Leu Met Gly Lys Tyr Val His Phe Ile Thr 
65                  70                  75                  80  


Asn Pro Leu Ser Tyr His Lys Val Leu Cys His Gly Lys Tyr Phe Asp 
                85                  90                  95      


Trp Lys Lys Phe His Phe Ala Thr Ser Ala Lys Ala Phe Gly His Arg 
            100                 105                 110         


Ser Ile Asp Pro Met Asp Gly Asn Thr Thr Glu Asn Ile Asn Asp Thr 
        115                 120                 125             


Phe Ile Lys Thr Leu Gln Gly His Ala Leu Asn Ser Leu Thr Glu Ser 
    130                 135                 140                 


Met Met Glu Asn Leu Gln Arg Ile Met Arg Pro Pro Val Ser Ser Asn 
145                 150                 155                 160 


Ser Lys Thr Ala Ala Trp Val Thr Glu Gly Met Tyr Ser Phe Cys Tyr 
                165                 170                 175     


Arg Val Met Phe Glu Ala Gly Tyr Leu Thr Ile Phe Gly Arg Asp Leu 
            180                 185                 190         


Thr Arg Arg Asp Thr Gln Lys Ala His Ile Leu Asn Asn Leu Asp Asn 
        195                 200                 205             


Phe Lys Gln Phe Asp Lys Val Phe Pro Ala Leu Val Ala Gly Leu Pro 
    210                 215                 220                 


Ile His Met Phe Arg Thr Ala His Asn Ala Arg Glu Lys Leu Ala Glu 
225                 230                 235                 240 


Ser Leu Arg His Glu Asn Leu Gln Lys Arg Glu Ser Ile Ser Glu Leu 
                245                 250                 255     


Ile Ser Leu Arg Met Phe Leu Asn Asp Thr Leu Ser Thr Phe Asp Asp 
            260                 265                 270         


Leu Glu Lys Ala Lys Thr His Leu Val Val Leu Trp Ala Ser Gln Ala 
        275                 280                 285             


Asn Thr Ile Pro Ala Thr Phe Trp Ser Leu Phe Gln Met Ile Arg Asn 
    290                 295                 300                 


Pro Glu Ala Met Lys Ala Ala Thr Glu Glu Val Lys Arg Thr Leu Glu 
305                 310                 315                 320 


Asn Ala Gly Gln Lys Val Ser Leu Glu Gly Asn Pro Ile Cys Leu Ser 
                325                 330                 335     


Gln Ala Glu Leu Asn Asp Leu Pro Val Leu Asp Ser Ile Ile Lys Glu 
            340                 345                 350         


Ser Leu Arg Leu Ser Ser Ala Ser Leu Asn Ile Arg Thr Ala Lys Glu 
        355                 360                 365             


Asp Phe Thr Leu His Leu Glu Asp Gly Ser Tyr Asn Ile Arg Lys Asp 
    370                 375                 380                 


Asp Ile Ile Ala Leu Tyr Pro Gln Leu Met His Leu Asp Pro Glu Ile 
385                 390                 395                 400 


Tyr Pro Asp Pro Leu Thr Phe Lys Tyr Asp Arg Tyr Leu Asp Glu Asn 
                405                 410                 415     


Gly Lys Thr Lys Thr Thr Phe Tyr Cys Asn Gly Leu Lys Leu Lys Tyr 
            420                 425                 430         


Tyr Tyr Met Pro Phe Gly Ser Gly Ala Thr Ile Cys Pro Gly Arg Leu 
        435                 440                 445             


Phe Ala Ile His Glu Ile Lys Gln Phe Leu Ile Leu Met Leu Ser Tyr 
    450                 455                 460                 


Phe Glu Leu Glu Leu Ile Glu Gly Gln Ala Lys Cys Pro Pro Leu Asp 
465                 470                 475                 480 


Gln Ser Arg Ala Gly Leu Gly Ile Leu Pro Pro Leu Asn Asp Ile Glu 
                485                 490                 495     


Phe Lys Tyr Lys Phe Lys His Leu 
            500                 


<210>  2846
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP7B1__Homo_sapiens__NP_004811

<400>  2846

Met Ala Gly Glu Val Ser Ala Ala Thr Gly Arg Phe Ser Leu Glu Arg 
1               5                   10                  15      


Leu Gly Leu Pro Gly Leu Ala Leu Ala Ala Ala Leu Leu Leu Leu Ala 
            20                  25                  30          


Leu Cys Leu Leu Val Arg Arg Thr Arg Arg Pro Gly Glu Pro Pro Leu 
        35                  40                  45              


Ile Lys Gly Trp Leu Pro Tyr Leu Gly Val Val Leu Asn Leu Arg Lys 
    50                  55                  60                  


Asp Pro Leu Arg Phe Met Lys Thr Leu Gln Lys Gln His Gly Asp Thr 
65                  70                  75                  80  


Phe Thr Val Leu Leu Gly Gly Lys Tyr Ile Thr Phe Ile Leu Asp Pro 
                85                  90                  95      


Phe Gln Tyr Gln Leu Val Ile Lys Asn His Lys Gln Leu Ser Phe Arg 
            100                 105                 110         


Val Phe Ser Asn Lys Leu Leu Glu Lys Ala Phe Ser Ile Ser Gln Leu 
        115                 120                 125             


Gln Lys Asn His Asp Met Asn Asp Glu Leu His Leu Cys Tyr Gln Phe 
    130                 135                 140                 


Leu Gln Gly Lys Ser Leu Asp Ile Leu Leu Glu Ser Met Met Gln Asn 
145                 150                 155                 160 


Leu Lys Gln Val Phe Glu Pro Gln Leu Leu Lys Thr Thr Ser Trp Asp 
                165                 170                 175     


Thr Ala Glu Leu Tyr Pro Phe Cys Ser Ser Ile Ile Phe Glu Ile Thr 
            180                 185                 190         


Phe Thr Thr Ile Tyr Gly Lys Val Ile Val Cys Asp Asn Asn Lys Phe 
        195                 200                 205             


Ile Ser Glu Leu Arg Asp Asp Phe Leu Lys Phe Asp Asp Lys Phe Ala 
    210                 215                 220                 


Tyr Leu Val Ser Asn Ile Pro Ile Glu Leu Leu Gly Asn Val Lys Ser 
225                 230                 235                 240 


Ile Arg Glu Lys Ile Ile Lys Cys Phe Ser Ser Glu Lys Leu Ala Lys 
                245                 250                 255     


Met Gln Gly Trp Ser Glu Val Phe Gln Ser Arg Gln Asp Val Leu Glu 
            260                 265                 270         


Lys Tyr Tyr Val His Glu Asp Leu Glu Ile Gly Ala His His Leu Gly 
        275                 280                 285             


Phe Leu Trp Ala Ser Val Ala Asn Thr Ile Pro Thr Met Phe Trp Ala 
    290                 295                 300                 


Met Tyr Tyr Leu Leu Arg His Pro Glu Ala Met Ala Ala Val Arg Asp 
305                 310                 315                 320 


Glu Ile Asp Arg Leu Leu Gln Ser Thr Gly Gln Lys Lys Gly Ser Gly 
                325                 330                 335     


Phe Pro Ile His Leu Thr Arg Glu Gln Leu Asp Ser Leu Ile Cys Leu 
            340                 345                 350         


Glu Ser Ser Ile Phe Glu Ala Leu Arg Leu Ser Ser Tyr Ser Thr Thr 
        355                 360                 365             


Ile Arg Phe Val Glu Glu Asp Leu Thr Leu Ser Ser Glu Thr Gly Asp 
    370                 375                 380                 


Tyr Cys Val Arg Lys Gly Asp Leu Val Ala Ile Phe Pro Pro Val Leu 
385                 390                 395                 400 


His Gly Asp Pro Glu Ile Phe Glu Ala Pro Glu Glu Phe Arg Tyr Asp 
                405                 410                 415     


Arg Phe Ile Glu Asp Gly Lys Lys Lys Thr Thr Phe Phe Lys Arg Gly 
            420                 425                 430         


Lys Lys Leu Lys Cys Tyr Leu Met Pro Phe Gly Thr Gly Thr Ser Lys 
        435                 440                 445             


Cys Pro Gly Arg Phe Phe Ala Leu Met Glu Ile Lys Gln Leu Leu Val 
    450                 455                 460                 


Ile Leu Leu Thr Tyr Phe Asp Leu Glu Ile Ile Asp Asp Lys Pro Ile 
465                 470                 475                 480 


Gly Leu Asn Tyr Ser Arg Leu Leu Phe Gly Ile Gln Tyr Pro Asp Ser 
                485                 490                 495     


Asp Val Leu Phe Arg Tyr Lys Val Lys Ser 
            500                 505     


<210>  2847
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYP8B1__Homo_sapiens__NP_004382

<400>  2847

Met Val Leu Trp Gly Pro Val Leu Gly Ala Leu Leu Val Val Ile Ala 
1               5                   10                  15      


Gly Tyr Leu Cys Leu Pro Gly Met Leu Arg Gln Arg Arg Pro Trp Glu 
            20                  25                  30          


Pro Pro Leu Asp Lys Gly Thr Val Pro Trp Leu Gly His Ala Met Ala 
        35                  40                  45              


Phe Arg Lys Asn Met Phe Glu Phe Leu Lys Arg Met Arg Thr Lys His 
    50                  55                  60                  


Gly Asp Val Phe Thr Val Gln Leu Gly Gly Gln Tyr Phe Thr Phe Val 
65                  70                  75                  80  


Met Asp Pro Leu Ser Phe Gly Ser Ile Leu Lys Asp Thr Gln Arg Lys 
                85                  90                  95      


Leu Asp Phe Gly Gln Tyr Ala Lys Lys Leu Val Leu Lys Val Phe Gly 
            100                 105                 110         


Tyr Arg Ser Val Gln Gly Asp His Glu Met Ile His Ser Ala Ser Thr 
        115                 120                 125             


Lys His Leu Arg Gly Asp Gly Leu Lys Asp Leu Asn Glu Thr Met Leu 
    130                 135                 140                 


Asp Ser Leu Ser Phe Val Met Leu Thr Ser Lys Gly Trp Ser Leu Asp 
145                 150                 155                 160 


Ala Ser Cys Trp His Glu Asp Ser Leu Phe Arg Phe Cys Tyr Tyr Ile 
                165                 170                 175     


Leu Phe Thr Ala Gly Tyr Leu Ser Leu Phe Gly Tyr Thr Lys Asp Lys 
            180                 185                 190         


Glu Gln Asp Leu Leu Gln Ala Gly Glu Leu Phe Met Glu Phe Arg Lys 
        195                 200                 205             


Phe Asp Leu Leu Phe Pro Arg Phe Val Tyr Ser Leu Leu Trp Pro Arg 
    210                 215                 220                 


Glu Trp Leu Glu Val Gly Arg Leu Gln Arg Leu Phe His Lys Met Leu 
225                 230                 235                 240 


Ser Val Ser His Ser Gln Glu Lys Glu Gly Ile Ser Asn Trp Leu Gly 
                245                 250                 255     


Asn Met Leu Gln Phe Leu Arg Glu Gln Gly Val Pro Ser Ala Met Gln 
            260                 265                 270         


Asp Lys Phe Asn Phe Met Met Leu Trp Ala Ser Gln Gly Asn Thr Gly 
        275                 280                 285             


Pro Thr Ser Phe Trp Ala Leu Leu Tyr Leu Leu Lys His Pro Glu Ala 
    290                 295                 300                 


Ile Arg Ala Val Arg Glu Glu Ala Thr Gln Val Leu Gly Glu Ala Arg 
305                 310                 315                 320 


Leu Glu Thr Lys Gln Ser Phe Ala Phe Lys Leu Gly Ala Leu Gln His 
                325                 330                 335     


Thr Pro Val Leu Asp Ser Val Val Glu Glu Thr Leu Arg Leu Arg Ala 
            340                 345                 350         


Ala Pro Thr Leu Leu Arg Leu Val His Glu Asp Tyr Thr Leu Lys Met 
        355                 360                 365             


Ser Ser Gly Gln Glu Tyr Leu Phe Arg His Gly Asp Ile Leu Ala Leu 
    370                 375                 380                 


Phe Pro Tyr Leu Ser Val His Met Asp Pro Asp Ile His Pro Glu Pro 
385                 390                 395                 400 


Thr Val Phe Lys Tyr Asp Arg Phe Leu Asn Pro Asn Gly Ser Arg Lys 
                405                 410                 415     


Val Asp Phe Phe Lys Thr Gly Lys Lys Ile His His Tyr Thr Met Pro 
            420                 425                 430         


Trp Gly Ser Gly Val Ser Ile Cys Pro Gly Arg Phe Phe Ala Leu Ser 
        435                 440                 445             


Glu Val Lys Leu Phe Ile Leu Leu Met Val Thr His Phe Asp Leu Glu 
    450                 455                 460                 


Leu Val Asp Pro Asp Thr Pro Leu Pro His Val Asp Pro Gln Arg Trp 
465                 470                 475                 480 


Gly Phe Gly Thr Met Gln Pro Ser His Asp Val Arg Phe Arg Tyr Arg 
                485                 490                 495     


Leu His Pro Thr Glu 
            500     


<210>  2848
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYS1__Homo_sapiens__NP_001032237

<400>  2848

Met Gly Ser Gly Ser Ser Arg Ser Ser Arg Thr Leu Arg Arg Arg Arg 
1               5                   10                  15      


Ser Pro Glu Ser Leu Pro Ala Gly Pro Gly Ala Ala Ala Leu Glu Gly 
            20                  25                  30          


Gly Thr Arg Arg Arg Val Pro Val Ala Ala Ala Glu Val Pro Gly Ala 
        35                  40                  45              


Ala Ala Glu Glu Ala Pro Gly Arg Asp Pro Ser Pro Val Ala Pro Pro 
    50                  55                  60                  


Asp Gly Arg Asp Glu Thr Leu Arg Leu Leu Asp Glu Leu Leu Ala Glu 
65                  70                  75                  80  


Ser Ala Ala Trp Gly Pro Pro Glu Pro Ala Pro Arg Arg Pro Ala Arg 
                85                  90                  95      


Leu Arg Pro Thr Ala Val Ala Gly Ser Ala Val Cys Ala Glu Gln Ser 
            100                 105                 110         


Thr Glu Gly His Pro Gly Ser Gly Asn Val Ser Glu Ala Pro Gly Ser 
        115                 120                 125             


Gly Arg Lys Lys Pro Glu Arg Pro Ala Ala Ile Ser Tyr Asp His Ser 
    130                 135                 140                 


Glu Glu Gly Leu Met Ala Ser Ile Glu Arg Glu Tyr Cys Arg 
145                 150                 155             


<210>  2849
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYSLTR1__Homo_sapiens__NP_001269117

<400>  2849

Met Asp Glu Thr Gly Asn Leu Thr Val Ser Ser Ala Thr Cys His Asp 
1               5                   10                  15      


Thr Ile Asp Asp Phe Arg Asn Gln Val Tyr Ser Thr Leu Tyr Ser Met 
            20                  25                  30          


Ile Ser Val Val Gly Phe Phe Gly Asn Gly Phe Val Leu Tyr Val Leu 
        35                  40                  45              


Ile Lys Thr Tyr His Lys Lys Ser Ala Phe Gln Val Tyr Met Ile Asn 
    50                  55                  60                  


Leu Ala Val Ala Asp Leu Leu Cys Val Cys Thr Leu Pro Leu Arg Val 
65                  70                  75                  80  


Val Tyr Tyr Val His Lys Gly Ile Trp Leu Phe Gly Asp Phe Leu Cys 
                85                  90                  95      


Arg Leu Ser Thr Tyr Ala Leu Tyr Val Asn Leu Tyr Cys Ser Ile Phe 
            100                 105                 110         


Phe Met Thr Ala Met Ser Phe Phe Arg Cys Ile Ala Ile Val Phe Pro 
        115                 120                 125             


Val Gln Asn Ile Asn Leu Val Thr Gln Lys Lys Ala Arg Phe Val Cys 
    130                 135                 140                 


Val Gly Ile Trp Ile Phe Val Ile Leu Thr Ser Ser Pro Phe Leu Met 
145                 150                 155                 160 


Ala Lys Pro Gln Lys Asp Glu Lys Asn Asn Thr Lys Cys Phe Glu Pro 
                165                 170                 175     


Pro Gln Asp Asn Gln Thr Lys Asn His Val Leu Val Leu His Tyr Val 
            180                 185                 190         


Ser Leu Phe Val Gly Phe Ile Ile Pro Phe Val Ile Ile Ile Val Cys 
        195                 200                 205             


Tyr Thr Met Ile Ile Leu Thr Leu Leu Lys Lys Ser Met Lys Lys Asn 
    210                 215                 220                 


Leu Ser Ser His Lys Lys Ala Ile Gly Met Ile Met Val Val Thr Ala 
225                 230                 235                 240 


Ala Phe Leu Val Ser Phe Met Pro Tyr His Ile Gln Arg Thr Ile His 
                245                 250                 255     


Leu His Phe Leu His Asn Glu Thr Lys Pro Cys Asp Ser Val Leu Arg 
            260                 265                 270         


Met Gln Lys Ser Val Val Ile Thr Leu Ser Leu Ala Ala Ser Asn Cys 
        275                 280                 285             


Cys Phe Asp Pro Leu Leu Tyr Phe Phe Ser Gly Gly Asn Phe Arg Lys 
    290                 295                 300                 


Arg Leu Ser Thr Phe Arg Lys His Ser Leu Ser Ser Val Thr Tyr Val 
305                 310                 315                 320 


Pro Arg Lys Lys Ala Ser Leu Pro Glu Lys Gly Glu Glu Ile Cys Lys 
                325                 330                 335     


Val 
    


<210>  2850
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYTH1__Homo_sapiens__NP_004753

<400>  2850

Met Glu Glu Asp Asp Ser Tyr Val Pro Ser Asp Leu Thr Ala Glu Glu 
1               5                   10                  15      


Arg Gln Glu Leu Glu Asn Ile Arg Arg Arg Lys Gln Glu Leu Leu Ala 
            20                  25                  30          


Asp Ile Gln Arg Leu Lys Asp Glu Ile Ala Glu Val Ala Asn Glu Ile 
        35                  40                  45              


Glu Asn Leu Gly Ser Thr Glu Glu Arg Lys Asn Met Gln Arg Asn Lys 
    50                  55                  60                  


Gln Val Ala Met Gly Arg Lys Lys Phe Asn Met Asp Pro Lys Lys Gly 
65                  70                  75                  80  


Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Lys Asn Thr Cys Glu Asp 
                85                  90                  95      


Ile Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn Lys Thr Ala Ile 
            100                 105                 110         


Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile Gln Val Leu His 
        115                 120                 125             


Ala Phe Val Glu Leu His Glu Phe Thr Asp Leu Asn Leu Val Gln Ala 
    130                 135                 140                 


Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly Glu Ala Gln Lys 
145                 150                 155                 160 


Ile Asp Arg Met Met Glu Ala Phe Ala Gln Arg Tyr Cys Gln Cys Asn 
                165                 170                 175     


Asn Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val Leu Ser Phe Ala 
            180                 185                 190         


Ile Ile Met Leu Asn Thr Ser Leu His Asn Pro Asn Val Lys Asp Lys 
        195                 200                 205             


Pro Thr Val Glu Arg Phe Ile Ala Met Asn Arg Gly Ile Asn Asp Gly 
    210                 215                 220                 


Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr Glu Ser Ile Lys 
225                 230                 235                 240 


Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn Asp Leu Thr His 
                245                 250                 255     


Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu Lys Leu Gly Gly 
            260                 265                 270         


Gly Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu Thr Asp Asn 
        275                 280                 285             


Cys Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro Arg Gly Ile 
    290                 295                 300                 


Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp Ser Lys Lys 
305                 310                 315                 320 


Pro Asn Cys Phe Glu Leu Tyr Ile Pro Asp Asn Lys Asp Gln Val Ile 
                325                 330                 335     


Lys Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu Gly Asn His 
            340                 345                 350         


Thr Val Tyr Arg Ile Ser Ala Pro Thr Pro Glu Glu Lys Glu Glu Trp 
        355                 360                 365             


Ile Lys Cys Ile Lys Ala Ala Ile Ser Arg Asp Pro Phe Tyr Glu Met 
    370                 375                 380                 


Leu Ala Ala Arg Lys Lys Lys Val Ser Ser Thr Lys Arg His 
385                 390                 395             


<210>  2851
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYTH3__Homo_sapiens__NP_004218

<400>  2851

Met Asp Glu Asp Gly Gly Gly Glu Gly Gly Gly Val Pro Glu Asp Leu 
1               5                   10                  15      


Ser Leu Glu Glu Arg Glu Glu Leu Leu Asp Ile Arg Arg Arg Lys Lys 
            20                  25                  30          


Glu Leu Ile Asp Asp Ile Glu Arg Leu Lys Tyr Glu Ile Ala Glu Val 
        35                  40                  45              


Met Thr Glu Ile Asp Asn Leu Thr Ser Val Glu Glu Ser Lys Thr Thr 
    50                  55                  60                  


Gln Arg Asn Lys Gln Ile Ala Met Gly Arg Lys Lys Phe Asn Met Asp 
65                  70                  75                  80  


Pro Lys Lys Gly Ile Gln Phe Leu Ile Glu Asn Asp Leu Leu Gln Ser 
                85                  90                  95      


Ser Pro Glu Asp Val Ala Gln Phe Leu Tyr Lys Gly Glu Gly Leu Asn 
            100                 105                 110         


Lys Thr Val Ile Gly Asp Tyr Leu Gly Glu Arg Asp Glu Phe Asn Ile 
        115                 120                 125             


Lys Val Leu Gln Ala Phe Val Glu Leu His Glu Phe Ala Asp Leu Asn 
    130                 135                 140                 


Leu Val Gln Ala Leu Arg Gln Phe Leu Trp Ser Phe Arg Leu Pro Gly 
145                 150                 155                 160 


Glu Ala Gln Lys Ile Asp Arg Met Met Glu Ala Phe Ala Ser Arg Tyr 
                165                 170                 175     


Cys Leu Cys Asn Pro Gly Val Phe Gln Ser Thr Asp Thr Cys Tyr Val 
            180                 185                 190         


Leu Ser Phe Ala Ile Ile Met Leu Asn Thr Ser Leu His Asn His Asn 
        195                 200                 205             


Val Arg Asp Lys Pro Thr Ala Glu Arg Phe Ile Ala Met Asn Arg Gly 
    210                 215                 220                 


Ile Asn Glu Gly Gly Asp Leu Pro Glu Glu Leu Leu Arg Asn Leu Tyr 
225                 230                 235                 240 


Glu Ser Ile Lys Asn Glu Pro Phe Lys Ile Pro Glu Asp Asp Gly Asn 
                245                 250                 255     


Asp Leu Thr His Thr Phe Phe Asn Pro Asp Arg Glu Gly Trp Leu Leu 
            260                 265                 270         


Lys Leu Gly Gly Arg Val Lys Thr Trp Lys Arg Arg Trp Phe Ile Leu 
        275                 280                 285             


Thr Asp Asn Cys Leu Tyr Tyr Phe Glu Tyr Thr Thr Asp Lys Glu Pro 
    290                 295                 300                 


Arg Gly Ile Ile Pro Leu Glu Asn Leu Ser Ile Arg Glu Val Glu Asp 
305                 310                 315                 320 


Pro Arg Lys Pro Asn Cys Phe Glu Leu Tyr Asn Pro Ser His Lys Gly 
                325                 330                 335     


Gln Val Ile Lys Ala Cys Lys Thr Glu Ala Asp Gly Arg Val Val Glu 
            340                 345                 350         


Gly Asn His Val Val Tyr Arg Ile Ser Ala Pro Ser Pro Glu Glu Lys 
        355                 360                 365             


Glu Glu Trp Met Lys Ser Ile Lys Ala Ser Ile Ser Arg Asp Pro Phe 
    370                 375                 380                 


Tyr Asp Met Leu Ala Thr Arg Lys Arg Arg Ile Ala Asn Lys Lys 
385                 390                 395                 


<210>  2852
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYTIP__Homo_sapiens__NP_004279

<400>  2852

Met Ser Leu Gln Arg Leu Leu Gln His Ser Ser Asn Gly Asn Leu Ala 
1               5                   10                  15      


Asp Phe Cys Ala Gly Pro Ala Tyr Ser Ser Tyr Ser Thr Leu Thr Gly 
            20                  25                  30          


Ser Leu Thr Met Asp Asp Asn Arg Arg Ile Gln Met Leu Ala Asp Thr 
        35                  40                  45              


Val Ala Thr Leu Pro Arg Gly Arg Lys Gln Leu Ala Leu Thr Arg Ser 
    50                  55                  60                  


Ser Ser Leu Ser Asp Phe Ser Trp Ser Gln Arg Lys Leu Val Thr Val 
65                  70                  75                  80  


Glu Lys Gln Asp Asn Glu Thr Phe Gly Phe Glu Ile Gln Ser Tyr Arg 
                85                  90                  95      


Pro Gln Asn Gln Asn Ala Cys Ser Ser Glu Met Phe Thr Leu Ile Cys 
            100                 105                 110         


Lys Ile Gln Glu Asp Ser Pro Ala His Cys Ala Gly Leu Gln Ala Gly 
        115                 120                 125             


Asp Val Leu Ala Asn Ile Asn Gly Val Ser Thr Glu Gly Phe Thr Tyr 
    130                 135                 140                 


Lys Gln Val Val Asp Leu Ile Arg Ser Ser Gly Asn Leu Leu Thr Ile 
145                 150                 155                 160 


Glu Thr Leu Asn Gly Thr Met Ile Leu Lys Arg Thr Glu Leu Glu Ala 
                165                 170                 175     


Lys Leu Gln Val Leu Lys Gln Thr Leu Lys Gln Lys Trp Val Glu Tyr 
            180                 185                 190         


Arg Ser Leu Gln Leu Gln Glu His Arg Leu Leu His Gly Asp Ala Ala 
        195                 200                 205             


Asn Cys Pro Ser Leu Glu Asn Met Asp Leu Asp Glu Leu Ser Leu Phe 
    210                 215                 220                 


Gly Pro Leu Pro Gly Pro Gly Pro Ala Leu Val Asp Arg Asn Arg Leu 
225                 230                 235                 240 


Ser Ser Glu Ser Ser Cys Lys Ser Trp Leu Ser Ser Met Thr Met Asp 
                245                 250                 255     


Ser Glu Asp Gly Tyr Gln Thr Cys Val Ser Glu Asp Ser Ser Arg Gly 
            260                 265                 270         


Ala Phe Ser Arg Gln Thr Ser Thr Asp Asp Glu Cys Phe Ile Pro Lys 
        275                 280                 285             


Glu Gly Asp Asp Phe Leu Arg Arg Ser Ser Ser Arg Arg Asn Arg Ser 
    290                 295                 300                 


Ile Ser Asn Thr Ser Ser Gly Ser Met Ser Pro Leu Trp Glu Gly Asn 
305                 310                 315                 320 


Leu Ser Ser Met Phe Gly Thr Leu Pro Arg Lys Ser Arg Lys Gly Ser 
                325                 330                 335     


Val Arg Lys Gln Leu Leu Lys Phe Ile Pro Gly Leu His Arg Ala Val 
            340                 345                 350         


Glu Glu Glu Glu Ser Arg Phe 
        355                 


<210>  2853
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYTL1__Homo_sapiens__NP_061129

<400>  2853

Met Arg Thr Pro Gly Pro Leu Pro Val Leu Leu Leu Leu Leu Ala Gly 
1               5                   10                  15      


Ala Pro Ala Ala Arg Pro Thr Pro Pro Thr Cys Tyr Ser Arg Met Arg 
            20                  25                  30          


Ala Leu Ser Gln Glu Ile Thr Arg Asp Phe Asn Leu Leu Gln Val Ser 
        35                  40                  45              


Glu Pro Ser Glu Pro Cys Val Arg Tyr Leu Pro Arg Leu Tyr Leu Asp 
    50                  55                  60                  


Ile His Asn Tyr Cys Val Leu Asp Lys Leu Arg Asp Phe Val Ala Ser 
65                  70                  75                  80  


Pro Pro Cys Trp Lys Val Ala Gln Val Asp Ser Leu Lys Asp Lys Ala 
                85                  90                  95      


Arg Lys Leu Tyr Thr Ile Met Asn Ser Phe Cys Arg Arg Asp Leu Val 
            100                 105                 110         


Phe Leu Leu Asp Asp Cys Asn Ala Leu Glu Tyr Pro Ile Pro Val Thr 
        115                 120                 125             


Thr Val Leu Pro Asp Arg Gln Arg 
    130                 135     


<210>  2854
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CYYR1__Homo_sapiens__NP_443186

<400>  2854

Met Lys Cys Glu Pro Gly Trp Pro Arg Thr Pro Glu Trp Pro Pro Ser 
1               5                   10                  15      


Pro Arg Leu Ser Ala Val Gly Arg Asp Lys Glu Thr Trp Ala Pro Ser 
            20                  25                  30          


Ala Ala Arg Leu Gly Pro Arg Ala Pro Gln Leu Arg Gly Val Pro Gln 
        35                  40                  45              


Ser Leu Ala Arg Asp Ala Pro Gly Pro Gly Ser Leu Gly Arg Leu Pro 
    50                  55                  60                  


Arg Gln Trp Pro Gly Leu Cys Ser Thr Arg Leu Ser Gly Ala Leu Leu 
65                  70                  75                  80  


Ser Pro Ser Asp Arg Pro Pro Ser Ser Pro Phe Pro Pro Val Pro Gly 
                85                  90                  95      


Ser Pro Phe Ala Pro Ser Leu Arg Pro Pro Ala Trp Met Asp Ala Pro 
            100                 105                 110         


Arg Leu Pro Val Arg Pro Gly Val Leu Leu Pro Lys Leu Val Leu Leu 
        115                 120                 125             


Phe Val Tyr Ala Asp Asp Cys Leu Ala Gln Cys Gly Lys Asp Cys Lys 
    130                 135                 140                 


Ser Tyr Cys Cys Asp Gly Thr Thr Pro Tyr Cys Cys Ser Tyr Tyr Ala 
145                 150                 155                 160 


Tyr Ile Gly Asn Ile Leu Ser Gly Thr Ala Ile Ala Gly Ile Val Phe 
                165                 170                 175     


Gly Ile Val Phe Ile Met Gly Val Ile Ala Gly Ile Ala Ile Cys Ile 
            180                 185                 190         


Cys Met Cys Met Lys Asn His Arg Ala Thr Arg Val Gly Ile Leu Arg 
        195                 200                 205             


Thr Thr His Ile Asn Thr Val Ser Ser Tyr Pro Gly Pro Pro Pro Tyr 
    210                 215                 220                 


Gly His Asp His Glu Met Glu Tyr Cys Ala Asp Leu Pro Pro Pro Tyr 
225                 230                 235                 240 


Ser Pro Thr Pro Gln Gly Pro Ala Gln Arg Ser Pro Pro Pro Pro Tyr 
                245                 250                 255     


Pro Gly Asn Ala Arg Lys 
            260         


<210>  2855
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2HGDH__Homo_sapiens__NP_001274178

<400>  2855

Met Val Gly Gly Ser Val Pro Val Phe Asp Glu Ile Ile Leu Ser Thr 
1               5                   10                  15      


Ala Arg Met Asn Arg Val Leu Ser Phe His Ser Val Ser Gly Ile Leu 
            20                  25                  30          


Val Cys Gln Ala Gly Cys Val Leu Glu Glu Leu Ser Arg Tyr Val Glu 
        35                  40                  45              


Glu Arg Asp Phe Ile Met Pro Leu Asp Leu Gly Ala Lys Gly Ser Cys 
    50                  55                  60                  


His Ile Gly Gly Asn Val Ala Thr Asn Ala Gly Gly Leu Arg Phe Leu 
65                  70                  75                  80  


Arg Tyr Gly Ser Leu His Gly Thr Val Leu Gly Leu Glu Val Val Leu 
                85                  90                  95      


Ala Asp Gly Thr Val Leu Asp Cys Leu Thr Ser Leu Arg Lys Asp Asn 
            100                 105                 110         


Thr Gly Tyr Asp Leu Lys Gln Leu Phe Ile Gly Ser Glu Gly Thr Leu 
        115                 120                 125             


Gly Ile Ile Thr Thr Val Ser Ile Leu Cys Pro Pro Lys Pro Arg Ala 
    130                 135                 140                 


Val Asn Val Ala Phe Leu Gly Cys Pro Gly Phe Ala Glu Val Leu Gln 
145                 150                 155                 160 


Thr Phe Ser Thr Cys Lys Gly Met Leu Gly Glu Ile Leu Ser Ala Phe 
                165                 170                 175     


Glu Phe Met Asp Ala Val Cys Met Gln Leu Val Gly Arg His Leu His 
            180                 185                 190         


Leu Ala Ser Pro Val Gln Glu Ser Pro Phe Tyr Val Leu Ile Glu Thr 
        195                 200                 205             


Ser Gly Ser Asn Ala Gly His Asp Ala Glu Lys Leu Gly His Phe Leu 
    210                 215                 220                 


Glu His Ala Leu Gly Ser Gly Leu Val Thr Asp Gly Thr Met Ala Thr 
225                 230                 235                 240 


Asp Gln Arg Lys Val Lys Met Leu Trp Ala Leu Arg Glu Arg Ile Thr 
                245                 250                 255     


Glu Ala Leu Ser Arg Asp Gly Tyr Val Tyr Lys Tyr Asp Leu Ser Leu 
            260                 265                 270         


Pro Val Glu Arg Leu Tyr Asp Ile Val Thr Asp Leu Arg Ala Arg Leu 
        275                 280                 285             


Gly Pro His Ala Lys His Val Val Gly Tyr Gly His Leu Gly Asp Gly 
    290                 295                 300                 


Asn Leu His Leu Asn Val Thr Ala Glu Ala Phe Ser Pro Ser Leu Leu 
305                 310                 315                 320 


Ala Ala Leu Glu Pro His Val Tyr Glu Trp Thr Ala Gly Gln Gln Gly 
                325                 330                 335     


Ser Val Ser Ala Glu His Gly Val Gly Phe Arg Lys Arg Asp Val Leu 
            340                 345                 350         


Gly Tyr Ser Lys Pro Pro Gly Ala Leu Gln Leu Met Gln Gln Leu Lys 
        355                 360                 365             


Ala Leu Leu Asp Pro Lys Gly Ile Leu Asn Pro Tyr Lys Thr Leu Pro 
    370                 375                 380                 


Ser Gln Ala 
385         


<210>  2856
<211>  1068
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAAM1__Homo_sapiens__NP_001257449

<400>  2856

Met Ala Pro Arg Lys Arg Gly Gly Arg Gly Ile Ser Phe Ile Phe Cys 
1               5                   10                  15      


Cys Phe Arg Asn Asn Asp His Pro Glu Ile Thr Tyr Arg Leu Arg Asn 
            20                  25                  30          


Asp Ser Asn Phe Ala Leu Gln Thr Met Glu Pro Ala Leu Pro Met Pro 
        35                  40                  45              


Pro Val Glu Glu Leu Asp Val Met Phe Ser Glu Leu Val Asp Glu Leu 
    50                  55                  60                  


Asp Leu Thr Asp Lys His Arg Glu Ala Met Phe Ala Leu Pro Ala Glu 
65                  70                  75                  80  


Lys Lys Trp Gln Ile Tyr Cys Ser Lys Lys Lys Asp Gln Glu Glu Asn 
                85                  90                  95      


Lys Gly Ala Thr Ser Trp Pro Glu Phe Tyr Ile Asp Gln Leu Asn Ser 
            100                 105                 110         


Met Ala Ala Arg Lys Ser Leu Leu Ala Leu Glu Lys Glu Glu Glu Glu 
        115                 120                 125             


Glu Arg Ser Lys Thr Ile Glu Ser Leu Lys Thr Ala Leu Arg Thr Lys 
    130                 135                 140                 


Pro Met Arg Phe Val Thr Arg Phe Ile Asp Leu Asp Gly Leu Ser Cys 
145                 150                 155                 160 


Ile Leu Asn Phe Leu Lys Thr Met Asp Tyr Glu Thr Ser Glu Ser Arg 
                165                 170                 175     


Ile His Thr Ser Leu Ile Gly Cys Ile Lys Ala Leu Met Asn Asn Ser 
            180                 185                 190         


Gln Gly Arg Ala His Val Leu Ala His Ser Glu Ser Ile Asn Val Ile 
        195                 200                 205             


Ala Gln Ser Leu Ser Thr Glu Asn Ile Lys Thr Lys Val Ala Val Leu 
    210                 215                 220                 


Glu Ile Leu Gly Ala Val Cys Leu Val Pro Gly Gly His Lys Lys Val 
225                 230                 235                 240 


Leu Gln Ala Met Leu His Tyr Gln Lys Tyr Ala Ser Glu Arg Thr Arg 
                245                 250                 255     


Phe Gln Thr Leu Ile Asn Asp Leu Asp Lys Ser Thr Gly Arg Tyr Arg 
            260                 265                 270         


Asp Glu Val Ser Leu Lys Thr Ala Ile Met Ser Phe Ile Asn Ala Val 
        275                 280                 285             


Leu Ser Gln Gly Ala Gly Val Glu Ser Leu Asp Phe Arg Leu His Leu 
    290                 295                 300                 


Arg Tyr Glu Phe Leu Met Leu Gly Ile Gln Pro Val Ile Asp Lys Leu 
305                 310                 315                 320 


Arg Glu His Glu Asn Ser Thr Leu Asp Arg His Leu Asp Phe Phe Glu 
                325                 330                 335     


Met Leu Arg Asn Glu Asp Glu Leu Glu Phe Ala Lys Arg Phe Glu Leu 
            340                 345                 350         


Val His Ile Asp Thr Lys Ser Ala Thr Gln Met Phe Glu Leu Thr Arg 
        355                 360                 365             


Lys Arg Leu Thr His Ser Glu Ala Tyr Pro His Phe Met Ser Ile Leu 
    370                 375                 380                 


His His Cys Leu Gln Met Pro Tyr Lys Arg Ser Gly Asn Thr Val Gln 
385                 390                 395                 400 


Tyr Trp Leu Leu Leu Asp Arg Ile Ile Gln Gln Ile Val Ile Gln Asn 
                405                 410                 415     


Asp Lys Gly Gln Asp Pro Asp Ser Thr Pro Leu Glu Asn Phe Asn Ile 
            420                 425                 430         


Lys Asn Val Val Arg Met Leu Val Asn Glu Asn Glu Val Lys Gln Trp 
        435                 440                 445             


Lys Glu Gln Ala Glu Lys Met Arg Lys Glu His Asn Glu Leu Gln Gln 
    450                 455                 460                 


Lys Leu Glu Lys Lys Glu Arg Glu Cys Asp Ala Lys Thr Gln Glu Lys 
465                 470                 475                 480 


Glu Glu Met Met Gln Thr Leu Asn Lys Met Lys Glu Lys Leu Glu Lys 
                485                 490                 495     


Glu Thr Thr Glu His Lys Gln Val Lys Gln Gln Val Ala Asp Leu Thr 
            500                 505                 510         


Ala Gln Leu His Glu Leu Ser Arg Arg Ala Val Cys Ala Ser Ile Pro 
        515                 520                 525             


Gly Gly Pro Ser Pro Gly Ala Pro Gly Gly Pro Phe Pro Ser Ser Val 
    530                 535                 540                 


Pro Gly Ser Leu Leu Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly 
545                 550                 555                 560 


Met Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Gly Pro Pro Pro 
                565                 570                 575     


Pro Pro Gly Pro Pro Pro Leu Gly Ala Ile Met Pro Pro Pro Gly Ala 
            580                 585                 590         


Pro Met Gly Leu Ala Leu Lys Lys Lys Ser Ile Pro Gln Pro Thr Asn 
        595                 600                 605             


Ala Leu Lys Ser Phe Asn Trp Ser Lys Leu Pro Glu Asn Lys Leu Glu 
    610                 615                 620                 


Gly Thr Val Trp Thr Glu Ile Asp Asp Thr Lys Val Phe Lys Ile Leu 
625                 630                 635                 640 


Asp Leu Glu Asp Leu Glu Arg Thr Phe Ser Ala Tyr Gln Arg Gln Gln 
                645                 650                 655     


Lys Glu Ala Asp Ala Ile Asp Asp Thr Leu Ser Ser Lys Leu Lys Val 
            660                 665                 670         


Lys Glu Leu Ser Val Ile Asp Gly Arg Arg Ala Gln Asn Cys Asn Ile 
        675                 680                 685             


Leu Leu Ser Arg Leu Lys Leu Ser Asn Asp Glu Ile Lys Arg Ala Ile 
    690                 695                 700                 


Leu Thr Met Asp Glu Gln Glu Asp Leu Pro Lys Asp Met Leu Glu Gln 
705                 710                 715                 720 


Leu Leu Lys Phe Val Pro Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu 
                725                 730                 735     


His Lys His Glu Leu Asp Arg Met Ala Lys Ala Asp Arg Phe Leu Phe 
            740                 745                 750         


Glu Met Ser Arg Ile Asn His Tyr Gln Gln Arg Leu Gln Ser Leu Tyr 
        755                 760                 765             


Phe Lys Lys Lys Phe Ala Glu Arg Val Ala Glu Val Lys Pro Lys Val 
    770                 775                 780                 


Glu Ala Ile Arg Ser Gly Ser Glu Glu Val Phe Arg Ser Gly Ala Leu 
785                 790                 795                 800 


Lys Gln Leu Leu Glu Val Val Leu Ala Phe Gly Asn Tyr Met Asn Lys 
                805                 810                 815     


Gly Gln Arg Gly Asn Ala Tyr Gly Phe Lys Ile Ser Ser Leu Asn Lys 
            820                 825                 830         


Ile Ala Asp Thr Lys Ser Ser Ile Asp Lys Asn Ile Thr Leu Leu His 
        835                 840                 845             


Tyr Leu Ile Thr Ile Val Glu Asn Lys Tyr Pro Ser Val Leu Asn Leu 
    850                 855                 860                 


Asn Glu Glu Leu Arg Asp Ile Pro Gln Ala Ala Lys Val Asn Met Thr 
865                 870                 875                 880 


Glu Leu Asp Lys Glu Ile Ser Thr Leu Arg Ser Gly Leu Lys Ala Val 
                885                 890                 895     


Glu Thr Glu Leu Glu Tyr Gln Lys Ser Gln Pro Pro Gln Pro Gly Asp 
            900                 905                 910         


Lys Phe Val Ser Val Val Ser Gln Phe Ile Thr Val Ala Ser Phe Ser 
        915                 920                 925             


Phe Ser Asp Val Glu Asp Leu Leu Ala Glu Ala Lys Asp Leu Phe Thr 
    930                 935                 940                 


Lys Ala Val Lys His Phe Gly Glu Glu Ala Gly Lys Ile Gln Pro Asp 
945                 950                 955                 960 


Glu Phe Phe Gly Ile Phe Asp Gln Phe Leu Gln Ala Val Ser Glu Ala 
                965                 970                 975     


Lys Gln Glu Asn Glu Asn Met Arg Lys Lys Lys Glu Glu Glu Glu Arg 
            980                 985                 990         


Arg Ala Arg Met Glu Ala Gln Leu  Lys Glu Gln Arg Glu  Arg Glu Arg 
        995                 1000                 1005             


Lys Met  Arg Lys Ala Lys Glu  Asn Ser Glu Glu Ser  Gly Glu Phe 
    1010                 1015                 1020             


Asp Asp  Leu Val Ser Ala Leu  Arg Ser Gly Glu Val  Phe Asp Lys 
    1025                 1030                 1035             


Asp Leu  Ser Lys Leu Lys Arg  Asn Arg Lys Arg Ile  Thr Asn Gln 
    1040                 1045                 1050             


Met Thr  Asp Ser Ser Arg Glu  Arg Pro Ile Thr Lys  Leu Asn Phe 
    1055                 1060                 1065             


<210>  2857
<211>  1068
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAAM2__Homo_sapiens__NP_001188356

<400>  2857

Met Ala Pro Arg Lys Arg Ser His His Gly Leu Gly Phe Leu Cys Cys 
1               5                   10                  15      


Phe Gly Gly Ser Asp Ile Pro Glu Ile Asn Leu Arg Asp Asn His Pro 
            20                  25                  30          


Leu Gln Phe Met Glu Phe Ser Ser Pro Ile Pro Asn Ala Glu Glu Leu 
        35                  40                  45              


Asn Ile Arg Phe Ala Glu Leu Val Asp Glu Leu Asp Leu Thr Asp Lys 
    50                  55                  60                  


Asn Arg Glu Ala Met Phe Ala Leu Pro Pro Glu Lys Lys Trp Gln Ile 
65                  70                  75                  80  


Tyr Cys Ser Lys Lys Lys Glu Gln Glu Asp Pro Asn Lys Leu Ala Thr 
                85                  90                  95      


Ser Trp Pro Asp Tyr Tyr Ile Asp Arg Ile Asn Ser Met Ala Ala Met 
            100                 105                 110         


Gln Ser Leu Tyr Ala Phe Asp Glu Glu Glu Thr Glu Met Arg Asn Gln 
        115                 120                 125             


Val Val Glu Asp Leu Lys Thr Ala Leu Arg Thr Gln Pro Met Arg Phe 
    130                 135                 140                 


Val Thr Arg Phe Ile Glu Leu Glu Gly Leu Thr Cys Leu Leu Asn Phe 
145                 150                 155                 160 


Leu Arg Ser Met Asp His Ala Thr Cys Glu Ser Arg Ile His Thr Ser 
                165                 170                 175     


Leu Ile Gly Cys Ile Lys Ala Leu Met Asn Asn Ser Gln Gly Arg Ala 
            180                 185                 190         


His Val Leu Ala Gln Pro Glu Ala Ile Ser Thr Ile Ala Gln Ser Leu 
        195                 200                 205             


Arg Thr Glu Asn Ser Lys Thr Lys Val Ala Val Leu Glu Ile Leu Gly 
    210                 215                 220                 


Ala Val Cys Leu Val Pro Gly Gly His Lys Lys Val Leu Gln Ala Met 
225                 230                 235                 240 


Leu His Tyr Gln Val Tyr Ala Ala Glu Arg Thr Arg Phe Gln Thr Leu 
                245                 250                 255     


Leu Asn Glu Leu Asp Arg Ser Leu Gly Arg Tyr Arg Asp Glu Val Asn 
            260                 265                 270         


Leu Lys Thr Ala Ile Met Ser Phe Ile Asn Ala Val Leu Asn Ala Gly 
        275                 280                 285             


Ala Gly Glu Asp Asn Leu Glu Phe Arg Leu His Leu Arg Tyr Glu Phe 
    290                 295                 300                 


Leu Met Leu Gly Ile Gln Pro Val Ile Asp Lys Leu Arg Gln His Glu 
305                 310                 315                 320 


Asn Ala Ile Leu Asp Lys His Leu Asp Phe Phe Glu Met Val Arg Asn 
                325                 330                 335     


Glu Asp Asp Leu Glu Leu Ala Arg Arg Phe Asp Met Val His Ile Asp 
            340                 345                 350         


Thr Lys Ser Ala Ser Gln Met Phe Glu Leu Ile His Lys Lys Leu Lys 
        355                 360                 365             


Tyr Thr Glu Ala Tyr Pro Cys Leu Leu Ser Val Leu His His Cys Leu 
    370                 375                 380                 


Gln Met Pro Tyr Lys Arg Asn Gly Gly Tyr Phe Gln Gln Trp Gln Leu 
385                 390                 395                 400 


Leu Asp Arg Ile Leu Gln Gln Ile Val Leu Gln Asp Glu Arg Gly Val 
                405                 410                 415     


Asp Pro Asp Leu Ala Pro Leu Glu Asn Phe Asn Val Lys Asn Ile Val 
            420                 425                 430         


Asn Met Leu Ile Asn Glu Asn Glu Val Lys Gln Trp Arg Asp Gln Ala 
        435                 440                 445             


Glu Lys Phe Arg Lys Glu His Met Glu Leu Val Ser Arg Leu Glu Arg 
    450                 455                 460                 


Lys Glu Arg Glu Cys Glu Thr Lys Thr Leu Glu Lys Glu Glu Met Met 
465                 470                 475                 480 


Arg Thr Leu Asn Lys Met Lys Asp Lys Leu Ala Arg Glu Ser Gln Glu 
                485                 490                 495     


Leu Arg Gln Ala Arg Gly Gln Val Ala Glu Leu Val Ala Gln Leu Ser 
            500                 505                 510         


Glu Leu Ser Thr Gly Pro Val Ser Ser Pro Pro Pro Pro Gly Gly Pro 
        515                 520                 525             


Leu Thr Leu Ser Ser Ser Met Thr Thr Asn Asp Leu Pro Pro Pro Pro 
    530                 535                 540                 


Pro Pro Leu Pro Phe Ala Cys Cys Pro Pro Pro Pro Pro Pro Pro Leu 
545                 550                 555                 560 


Pro Pro Gly Gly Pro Pro Thr Pro Pro Gly Ala Pro Pro Cys Leu Gly 
                565                 570                 575     


Met Gly Leu Pro Leu Pro Gln Asp Pro Tyr Pro Ser Ser Asp Val Pro 
            580                 585                 590         


Leu Arg Lys Lys Arg Val Pro Gln Pro Ser His Pro Leu Lys Ser Phe 
        595                 600                 605             


Asn Trp Val Lys Leu Asn Glu Glu Arg Val Pro Gly Thr Val Trp Asn 
    610                 615                 620                 


Glu Ile Asp Asp Met Gln Val Phe Arg Ile Leu Asp Leu Glu Asp Phe 
625                 630                 635                 640 


Glu Lys Met Phe Ser Ala Tyr Gln Arg His Gln Lys Glu Leu Gly Ser 
                645                 650                 655     


Thr Glu Asp Ile Tyr Leu Ala Ser Arg Lys Val Lys Glu Leu Ser Val 
            660                 665                 670         


Ile Asp Gly Arg Arg Ala Gln Asn Cys Ile Ile Leu Leu Ser Lys Leu 
        675                 680                 685             


Lys Leu Ser Asn Glu Glu Ile Arg Gln Ala Ile Leu Lys Met Asp Glu 
    690                 695                 700                 


Gln Glu Asp Leu Ala Lys Asp Met Leu Glu Gln Leu Leu Lys Phe Ile 
705                 710                 715                 720 


Pro Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu His Lys His Glu Ile 
                725                 730                 735     


Glu Arg Met Ala Arg Ala Asp Arg Phe Leu Tyr Glu Met Ser Arg Ile 
            740                 745                 750         


Asp His Tyr Gln Gln Arg Leu Gln Ala Leu Phe Phe Lys Lys Lys Phe 
        755                 760                 765             


Gln Glu Arg Leu Ala Glu Ala Lys Pro Lys Val Glu Ala Ile Leu Leu 
    770                 775                 780                 


Ala Ser Arg Glu Leu Val Arg Ser Lys Arg Leu Arg Gln Met Leu Glu 
785                 790                 795                 800 


Val Ile Leu Ala Ile Gly Asn Phe Met Asn Lys Gly Gln Arg Gly Gly 
                805                 810                 815     


Ala Tyr Gly Phe Arg Val Ala Ser Leu Asn Lys Ile Ala Asp Thr Lys 
            820                 825                 830         


Ser Ser Ile Asp Arg Asn Ile Ser Leu Leu His Tyr Leu Ile Met Ile 
        835                 840                 845             


Leu Glu Lys His Phe Pro Asp Ile Leu Asn Met Pro Ser Glu Leu Gln 
    850                 855                 860                 


His Leu Pro Glu Ala Ala Lys Val Asn Leu Ala Glu Leu Glu Lys Glu 
865                 870                 875                 880 


Val Gly Asn Leu Arg Arg Gly Leu Arg Ala Val Glu Val Glu Leu Glu 
                885                 890                 895     


Tyr Gln Arg Arg Gln Val Arg Glu Pro Ser Asp Lys Phe Val Pro Val 
            900                 905                 910         


Met Ser Asp Phe Ile Thr Val Ser Ser Phe Ser Phe Ser Glu Leu Glu 
        915                 920                 925             


Asp Gln Leu Asn Glu Ala Arg Asp Lys Phe Ala Lys Ala Leu Met His 
    930                 935                 940                 


Phe Gly Glu His Asp Ser Lys Met Gln Pro Asp Glu Phe Phe Gly Ile 
945                 950                 955                 960 


Phe Asp Thr Phe Leu Gln Ala Phe Ser Glu Ala Arg Gln Asp Leu Glu 
                965                 970                 975     


Ala Met Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Ala Arg Met Glu 
            980                 985                 990         


Ala Met Leu Lys Glu Gln Arg Glu  Arg Glu Arg Trp Gln  Arg Gln Arg 
        995                 1000                 1005             


Lys Val  Leu Ala Ala Gly Ser  Ser Leu Glu Glu Gly  Gly Glu Phe 
    1010                 1015                 1020             


Asp Asp  Leu Val Ser Ala Leu  Arg Ser Gly Glu Val  Phe Asp Lys 
    1025                 1030                 1035             


Asp Leu  Cys Lys Leu Lys Arg  Ser Arg Lys Arg Ser  Gly Ser Gln 
    1040                 1045                 1050             


Ala Leu  Glu Val Thr Arg Glu  Arg Ala Ile Asn Arg  Leu Asn Tyr 
    1055                 1060                 1065             


<210>  2858
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAB2__Homo_sapiens__NP_001231800

<400>  2858

Met Ser Asn Glu Val Glu Thr Ser Ala Thr Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Thr Asn Lys Leu Lys Ser 
        195                 200                 205             


Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn Ser Glu Ile Asp Thr 
    210                 215                 220                 


Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu Thr Asn Gly Ile Thr 
225                 230                 235                 240 


Ser Cys Ser Leu Pro Arg Pro Thr Pro Gln Ala Ser Phe Leu Pro Glu 
                245                 250                 255     


Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro Thr Pro Asn Pro Asp 
            260                 265                 270         


Pro Phe Arg Asp Asp Pro Phe Thr Gln Pro Asp Gln Ser Thr Pro Ser 
        275                 280                 285             


Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys Lys Glu Asn Ser Ser 
    290                 295                 300                 


Ser Ser Ser Thr Pro Leu Ser Asn Gly Pro Leu Asn Gly Asp Val Asp 
305                 310                 315                 320 


Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn Arg Thr Gly Lys Gln 
                325                 330                 335     


Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser Ser Gln Thr Gln Pro 
            340                 345                 350         


Ala Val Arg Thr Gln Asn Gly Val Ser Glu Arg Glu Gln Asn Gly Phe 
        355                 360                 365             


Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly Ser Pro Pro Lys Gly 
    370                 375                 380                 


Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu Glu Ser Ser Val Gln 
385                 390                 395                 400 


Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro Pro Pro Gln Ser Thr 
                405                 410                 415     


Lys Pro Gly Arg Gly Arg Arg Thr Ala Lys Ser Ser Ala Asn Asp Leu 
            420                 425                 430         


Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser Glu Pro Ser Gly Gln 
        435                 440                 445             


Ala Ser Pro Thr Gly Gln Pro Thr Ala Leu Gln Pro Asn Pro Leu Asp 
    450                 455                 460                 


Leu Phe Lys Thr Ser Ala Pro Ala Pro Val Gly Pro Leu Val Gly Leu 
465                 470                 475                 480 


Gly Gly Val Thr Val Thr Leu Pro Gln Ala Gly Pro Trp Asn Thr Ala 
                485                 490                 495     


Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala Pro Gly Ala Met Met 
            500                 505                 510         


Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val Ile Phe Gly Thr Ser 
        515                 520                 525             


Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro Phe Ala Ala Ser Thr 
    530                 535                 540                 


Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser Ala Ser Val Ala Pro 
545                 550                 555                 560 


Asn Ala Trp Ser Thr Thr Ser Pro Leu Gly Asn Pro Phe Gln Ser Asn 
                565                 570                 575     


Ile Phe Pro Ala Pro Ala Val Ser Thr Gln Pro Pro Ser Met His Ser 
            580                 585                 590         


Ser Leu Leu Val Thr Pro Pro Gln Pro Pro Pro Arg Ala Gly Pro Pro 
        595                 600                 605             


Lys Asp Ile Ser Ser Asp Ala Phe Thr Ala Leu Asp Pro Leu Gly Asp 
    610                 615                 620                 


Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys Asp Phe Gln Leu Arg 
625                 630                 635                 640 


Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu Gln Thr Ser Ser Gly 
                645                 650                 655     


Thr Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser Lys Val Gly Ile Pro 
            660                 665                 670         


Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala Asn Gln Leu Leu Asn 
        675                 680                 685             


Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg Gln Val Ser Leu Pro 
    690                 695                 700                 


Val Thr Lys Ser Thr Asp Asn Ala Phe Glu Asn Pro Phe Phe Lys Asp 
705                 710                 715                 720 


Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser Ser Gln Pro Val Ser 
                725                 730                 735     


Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro Phe Ala 
            740                 745                 


<210>  2859
<211>  1132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAB2IP__Homo_sapiens__NP_115941

<400>  2859

Met Glu Pro Asp Ser Leu Leu Asp Gln Asp Asp Ser Tyr Glu Ser Pro 
1               5                   10                  15      


Gln Glu Arg Pro Gly Ser Arg Arg Ser Leu Pro Gly Ser Leu Ser Glu 
            20                  25                  30          


Lys Ser Pro Ser Met Glu Pro Ser Ala Ala Thr Pro Phe Arg Val Thr 
        35                  40                  45              


Gly Phe Leu Ser Arg Arg Leu Lys Gly Ser Ile Lys Arg Thr Lys Ser 
    50                  55                  60                  


Gln Pro Lys Leu Asp Arg Asn His Ser Phe Arg His Ile Leu Pro Gly 
65                  70                  75                  80  


Phe Arg Ser Ala Ala Ala Ala Ala Ala Asp Asn Glu Arg Ser His Leu 
                85                  90                  95      


Met Pro Arg Leu Lys Glu Ser Arg Ser His Glu Ser Leu Leu Ser Pro 
            100                 105                 110         


Ser Ser Ala Val Glu Ala Leu Asp Leu Ser Met Glu Glu Glu Val Val 
        115                 120                 125             


Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Asp Tyr Cys Phe Glu 
    130                 135                 140                 


Val Thr Thr Ser Ser Gly Ser Lys Cys Phe Ser Cys Arg Ser Ala Ala 
145                 150                 155                 160 


Glu Arg Asp Lys Trp Met Glu Asn Leu Arg Arg Ala Val His Pro Asn 
                165                 170                 175     


Lys Asp Asn Ser Arg Arg Val Glu His Ile Leu Lys Leu Trp Val Ile 
            180                 185                 190         


Glu Ala Lys Asp Leu Pro Ala Lys Lys Lys Tyr Leu Cys Glu Leu Cys 
        195                 200                 205             


Leu Asp Asp Val Leu Tyr Ala Arg Thr Thr Gly Lys Leu Lys Thr Asp 
    210                 215                 220                 


Asn Val Phe Trp Gly Glu His Phe Glu Phe His Asn Leu Pro Pro Leu 
225                 230                 235                 240 


Arg Thr Val Thr Val His Leu Tyr Arg Glu Thr Asp Lys Lys Lys Lys 
                245                 250                 255     


Lys Glu Arg Asn Ser Tyr Leu Gly Leu Val Ser Leu Pro Ala Ala Ser 
            260                 265                 270         


Val Ala Gly Arg Gln Phe Val Glu Lys Trp Tyr Pro Val Val Thr Pro 
        275                 280                 285             


Asn Pro Lys Gly Gly Lys Gly Pro Gly Pro Met Ile Arg Ile Lys Ala 
    290                 295                 300                 


Arg Tyr Gln Thr Ile Thr Ile Leu Pro Met Glu Met Tyr Lys Glu Phe 
305                 310                 315                 320 


Ala Glu His Ile Thr Asn His Tyr Leu Gly Leu Cys Ala Ala Leu Glu 
                325                 330                 335     


Pro Ile Leu Ser Ala Lys Thr Lys Glu Glu Met Ala Ser Ala Leu Val 
            340                 345                 350         


His Ile Leu Gln Ser Thr Gly Lys Val Lys Asp Phe Leu Thr Asp Leu 
        355                 360                 365             


Met Met Ser Glu Val Asp Arg Cys Gly Asp Asn Glu His Leu Ile Phe 
    370                 375                 380                 


Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu Tyr Leu Lys Leu 
385                 390                 395                 400 


Val Gly Gln Lys Tyr Leu Gln Asp Ala Leu Gly Glu Phe Ile Lys Ala 
                405                 410                 415     


Leu Tyr Glu Ser Asp Glu Asn Cys Glu Val Asp Pro Ser Lys Cys Ser 
            420                 425                 430         


Ala Ala Asp Leu Pro Glu His Gln Gly Asn Leu Lys Met Cys Cys Glu 
        435                 440                 445             


Leu Ala Phe Cys Lys Ile Ile Asn Ser Tyr Cys Val Phe Pro Arg Glu 
    450                 455                 460                 


Leu Lys Glu Val Phe Ala Ser Trp Arg Gln Glu Cys Ser Ser Arg Gly 
465                 470                 475                 480 


Arg Pro Asp Ile Ser Glu Arg Leu Ile Ser Ala Ser Leu Phe Leu Arg 
                485                 490                 495     


Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe Asn Leu Leu Gln 
            500                 505                 510         


Glu Tyr Pro Asp Asp Arg Thr Ala Arg Thr Leu Thr Leu Ile Ala Lys 
        515                 520                 525             


Val Thr Gln Asn Leu Ala Asn Phe Ala Lys Phe Gly Ser Lys Glu Glu 
    530                 535                 540                 


Tyr Met Ser Phe Met Asn Gln Phe Leu Glu His Glu Trp Thr Asn Met 
545                 550                 555                 560 


Gln Arg Phe Leu Leu Glu Ile Ser Asn Pro Glu Thr Leu Ser Asn Thr 
                565                 570                 575     


Ala Gly Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu Leu Ser Ser Leu 
            580                 585                 590         


His Ser Leu Leu Trp Glu Ala Val Ser Gln Leu Glu Gln Ser Ile Val 
        595                 600                 605             


Ser Lys Leu Gly Pro Leu Pro Arg Ile Leu Arg Asp Val His Thr Ala 
    610                 615                 620                 


Leu Ser Thr Pro Gly Ser Gly Gln Leu Pro Gly Thr Asn Asp Leu Ala 
625                 630                 635                 640 


Ser Thr Pro Gly Ser Gly Ser Ser Ser Ile Ser Ala Gly Leu Gln Lys 
                645                 650                 655     


Met Val Ile Glu Asn Asp Leu Ser Gly Leu Ile Asp Phe Thr Arg Leu 
            660                 665                 670         


Pro Ser Pro Thr Pro Glu Asn Lys Asp Leu Phe Phe Val Thr Arg Ser 
        675                 680                 685             


Ser Gly Val Gln Pro Ser Pro Ala Arg Ser Ser Ser Tyr Ser Glu Ala 
    690                 695                 700                 


Asn Glu Pro Asp Leu Gln Met Ala Asn Gly Gly Lys Ser Leu Ser Met 
705                 710                 715                 720 


Val Asp Leu Gln Asp Ala Arg Thr Leu Asp Gly Glu Ala Gly Ser Pro 
                725                 730                 735     


Ala Gly Pro Asp Val Leu Pro Thr Asp Gly Gln Ala Ala Ala Ala Gln 
            740                 745                 750         


Leu Val Ala Gly Trp Pro Ala Arg Ala Thr Pro Val Asn Leu Ala Gly 
        755                 760                 765             


Leu Ala Thr Val Arg Arg Ala Gly Gln Thr Pro Thr Thr Pro Gly Thr 
    770                 775                 780                 


Ser Glu Gly Ala Pro Gly Arg Pro Gln Leu Leu Ala Pro Leu Ser Phe 
785                 790                 795                 800 


Gln Asn Pro Val Tyr Gln Met Ala Ala Gly Leu Pro Leu Ser Pro Arg 
                805                 810                 815     


Gly Leu Gly Asp Ser Gly Ser Glu Gly His Ser Ser Leu Ser Ser His 
            820                 825                 830         


Ser Asn Ser Glu Glu Leu Ala Ala Ala Ala Lys Leu Gly Ser Phe Ser 
        835                 840                 845             


Thr Ala Ala Glu Glu Leu Ala Arg Arg Pro Gly Glu Leu Ala Arg Arg 
    850                 855                 860                 


Gln Met Ser Leu Thr Glu Lys Gly Gly Gln Pro Thr Val Pro Arg Gln 
865                 870                 875                 880 


Asn Ser Ala Gly Pro Gln Arg Arg Ile Asp Gln Pro Pro Pro Pro Pro 
                885                 890                 895     


Pro Pro Pro Pro Pro Ala Pro Arg Gly Arg Thr Pro Pro Asn Leu Leu 
            900                 905                 910         


Ser Thr Leu Gln Tyr Pro Arg Pro Ser Ser Gly Thr Leu Ala Ser Ala 
        915                 920                 925             


Ser Pro Asp Trp Val Gly Pro Ser Thr Arg Leu Arg Gln Gln Ser Ser 
    930                 935                 940                 


Ser Ser Lys Gly Asp Ser Pro Glu Leu Lys Pro Arg Ala Val His Lys 
945                 950                 955                 960 


Gln Gly Pro Ser Pro Val Ser Pro Asn Ala Leu Asp Arg Thr Ala Ala 
                965                 970                 975     


Trp Leu Leu Thr Met Asn Ala Gln Leu Leu Glu Asp Glu Gly Leu Gly 
            980                 985                 990         


Pro Asp Pro Pro His Arg Asp Arg  Leu Arg Ser Lys Asp  Glu Leu Ser 
        995                 1000                 1005             


Gln Ala  Glu Lys Asp Leu Ala  Val Leu Gln Asp Lys  Leu Arg Ile 
    1010                 1015                 1020             


Ser Thr  Lys Lys Leu Glu Glu  Tyr Glu Thr Leu Phe  Lys Cys Gln 
    1025                 1030                 1035             


Glu Glu  Thr Thr Gln Lys Leu  Val Leu Glu Tyr Gln  Ala Arg Leu 
    1040                 1045                 1050             


Glu Glu  Gly Glu Glu Arg Leu  Arg Arg Gln Gln Glu  Asp Lys Asp 
    1055                 1060                 1065             


Ile Gln  Met Lys Gly Ile Ile  Ser Arg Leu Met Ser  Val Glu Glu 
    1070                 1075                 1080             


Glu Leu  Lys Lys Asp His Ala  Glu Met Gln Ala Ala  Val Asp Ser 
    1085                 1090                 1095             


Lys Gln  Lys Ile Ile Asp Ala  Gln Glu Lys Arg Ile  Ala Ser Leu 
    1100                 1105                 1110             


Asp Ala  Ala Asn Ala Arg Leu  Met Ser Ala Leu Thr  Gln Leu Lys 
    1115                 1120                 1125             


Glu Ser  Met His 
    1130         


<210>  2860
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DACH1__Homo_sapiens__NP_004383

<400>  2860

Met Ala Val Pro Ala Ala Leu Ile Pro Pro Thr Gln Leu Val Pro Pro 
1               5                   10                  15      


Gln Pro Pro Ile Ser Thr Ser Ala Ser Ser Ser Gly Thr Thr Thr Ser 
            20                  25                  30          


Thr Ser Ser Ala Thr Ser Ser Pro Ala Pro Ser Ile Gly Pro Pro Ala 
        35                  40                  45              


Ser Ser Gly Pro Thr Leu Phe Arg Pro Glu Pro Ile Ala Ser Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Thr Val Thr Ser Thr Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Gly Ser Ser Gly Asn Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Ser Asn Cys Asn Pro Asn Leu Ala Ala Ala Ser 
            100                 105                 110         


Asn Gly Ser Gly Gly Gly Gly Gly Gly Ile Ser Ala Gly Gly Gly Val 
        115                 120                 125             


Ala Ser Ser Thr Pro Ile Asn Ala Ser Thr Gly Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Ser Ser Ser Cys Gly Pro Leu Pro Gly Lys Pro Val Tyr Ser Thr Pro 
                165                 170                 175     


Ser Pro Val Glu Asn Thr Pro Gln Asn Asn Glu Cys Lys Met Val Asp 
            180                 185                 190         


Leu Arg Gly Ala Lys Val Ala Ser Phe Thr Val Glu Gly Cys Glu Leu 
        195                 200                 205             


Ile Cys Leu Pro Gln Ala Phe Asp Leu Phe Leu Lys His Leu Val Gly 
    210                 215                 220                 


Gly Leu His Thr Val Tyr Thr Lys Leu Lys Arg Leu Glu Ile Thr Pro 
225                 230                 235                 240 


Val Val Cys Asn Val Glu Gln Val Arg Ile Leu Arg Gly Leu Gly Ala 
                245                 250                 255     


Ile Gln Pro Gly Val Asn Arg Cys Lys Leu Ile Ser Arg Lys Asp Phe 
            260                 265                 270         


Glu Thr Leu Tyr Asn Asp Cys Thr Asn Ala Ser Ser Arg Pro Gly Arg 
        275                 280                 285             


Pro Pro Lys Arg Thr Gln Ser Val Thr Ser Pro Glu Asn Ser His Ile 
    290                 295                 300                 


Met Pro His Ser Val Pro Gly Leu Met Ser Pro Gly Ile Ile Pro Pro 
305                 310                 315                 320 


Thr Asp Glu Thr Pro Leu Ser Thr Pro Thr Ala Arg Asp Ser Leu Asp 
                325                 330                 335     


Lys Leu Ser Leu Thr Gly His Gly Gln Pro Leu Pro Pro Gly Phe Pro 
            340                 345                 350         


Ser Pro Phe Leu Phe Pro Asp Gly Leu Ser Ser Ile Glu Thr Leu Leu 
        355                 360                 365             


Thr Asn Ile Gln Gly Leu Leu Lys Val Ala Ile Asp Asn Ala Arg Ala 
    370                 375                 380                 


Gln Glu Lys Gln Val Gln Leu Glu Lys Thr Glu Leu Lys Met Asp Phe 
385                 390                 395                 400 


Leu Arg Glu Arg Glu Leu Arg Glu Thr Leu Glu Lys Gln Leu Ala Met 
                405                 410                 415     


Glu Gln Lys Asn Arg Ala Ile Val Gln Lys Arg Leu Lys Lys Glu Lys 
            420                 425                 430         


Lys Ala Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Thr Lys Arg 
        435                 440                 445             


Arg Glu Gln Ala Glu Gln Thr Leu Lys Gln Ala Ala Ser Thr Asp Ser 
    450                 455                 460                 


Leu Arg Val Leu Asn Asp Ser Leu Thr Pro Glu Ile Glu Ala Asp Arg 
465                 470                 475                 480 


Ser Gly Gly Arg Thr Asp Ala Glu Arg Thr Ile Gln Asp Gly Arg Leu 
                485                 490                 495     


Tyr Leu Lys Thr Thr Val Met Tyr 
            500                 


<210>  2861
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DACH2__Homo_sapiens__NP_001132986

<400>  2861

Met Ala Val Ser Ala Ser Pro Val Ile Ser Ala Thr Ser Ser Gly Ala 
1               5                   10                  15      


Gly Val Pro Gly Gly Leu Phe Arg Ala Glu Pro Leu Tyr Ser Thr Pro 
            20                  25                  30          


Arg Glu Pro Pro Arg Leu Thr Pro Asn Met Ile Asn Ser Phe Val Val 
        35                  40                  45              


Asn Asn His Ser Asn Ser Ala Gly Gly Gly Gly Arg Gly Asn Thr Asn 
    50                  55                  60                  


Thr Asn Glu Cys Arg Met Val Asp Met His Gly Met Lys Val Ala Ser 
65                  70                  75                  80  


Phe Leu Met Asp Gly Gln Glu Leu Ile Cys Leu Pro Gln Val Phe Asp 
                85                  90                  95      


Leu Phe Leu Lys His Leu Val Gly Gly Leu His Thr Val Tyr Thr Lys 
            100                 105                 110         


Leu Lys Arg Leu Asp Ile Ser Pro Val Val Cys Thr Val Glu Gln Val 
        115                 120                 125             


Arg Ile Leu Arg Gly Leu Gly Ala Ile Gln Pro Gly Val Asn Arg Cys 
    130                 135                 140                 


Lys Leu Ile Thr Arg Lys Asp Phe Glu Thr Leu Phe Thr Asp Cys Thr 
145                 150                 155                 160 


Asn Ala Ser Ser Arg Pro Gly Arg Pro Pro Lys Arg Ser Leu Gly Val 
                165                 170                 175     


Leu Gln Glu Asn Ala Arg Leu Leu Thr His Ala Val Pro Gly Leu Leu 
            180                 185                 190         


Ser Pro Gly Leu Ile Thr Pro Thr Gly Ile Thr Ala Ala Ala Met Ala 
        195                 200                 205             


Glu Ala Met Lys Leu Gln Lys Met Lys Leu Met Ala Met Asn Thr Leu 
    210                 215                 220                 


Gln Gly Asn Gly Ser Gln Asn Gly Thr Glu Ser Glu Pro Asp Asp Leu 
225                 230                 235                 240 


Asn Ser Asn Thr Gly Gly Ser Glu Ser Ser Trp Asp Lys Asp Lys Met 
                245                 250                 255     


Gln Ser Pro Phe Ala Ala Pro Gly Pro Gln His Gly Ile Ala His Ala 
            260                 265                 270         


Ala Leu Ala Gly Gln Pro Gly Ile Gly Gly Ala Pro Thr Leu Asn Pro 
        275                 280                 285             


Leu Gln Gln Asn His Leu Leu Thr Asn Arg Leu Asp Leu Pro Phe Met 
    290                 295                 300                 


Met Met Pro His Pro Leu Leu Pro Val Ser Leu Pro Pro Ala Ser Val 
305                 310                 315                 320 


Ala Met Ala Met Asn Gln Met Asn His Leu Asn Thr Ile Ala Asn Met 
                325                 330                 335     


Ala Ala Ala Ala Gln Ile His Ser Pro Leu Ser Arg Ala Gly Thr Ser 
            340                 345                 350         


Val Ile Lys Glu Arg Ile Pro Glu Ser Pro Ser Pro Ala Pro Ser Leu 
        355                 360                 365             


Glu Glu Asn His Arg Pro Gly Ser Gln Thr Ser Ser His Thr Ser Ser 
    370                 375                 380                 


Ser Val Ser Ser Ser Pro Ser Gln Met Asp His His Leu Glu Arg Met 
385                 390                 395                 400 


Glu Glu Val Pro Val Gln Ile Pro Ile Met Lys Ser Pro Leu Asp Lys 
                405                 410                 415     


Ile Gln Leu Thr Pro Gly Gln Ala Leu Pro Ala Gly Phe Pro Gly Pro 
            420                 425                 430         


Phe Ile Phe Ala Asp Ser Leu Ser Ser Val Glu Thr Leu Leu Thr Asn 
        435                 440                 445             


Ile Gln Gly Leu Leu Lys Val Ala Leu Asp Asn Ala Arg Ile Gln Glu 
    450                 455                 460                 


Lys Gln Ile Gln Gln Glu Lys Lys Glu Leu Arg Leu Glu Leu Tyr Arg 
465                 470                 475                 480 


Glu Arg Glu Ile Arg Glu Asn Leu Glu Arg Gln Leu Ala Val Glu Leu 
                485                 490                 495     


Gln Ser Arg Thr Thr Met Gln Lys Arg Leu Lys Lys Glu Lys Lys Thr 
            500                 505                 510         


Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Ser Lys Arg Arg Glu 
        515                 520                 525             


Gln Val Glu Gln Ala Leu Lys Gln Ala Thr Thr Ser Asp Ser Gly Leu 
    530                 535                 540                 


Arg Met Leu Lys Asp Thr Gly Ile Pro Asp Ile Glu Ile Glu Asn Asn 
545                 550                 555                 560 


Gly Thr Pro His Asp Ser Ala Ala Met Gln Ala 
                565                 570     


<210>  2862
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DACT1__Homo_sapiens__NP_001072988

<400>  2862

Met Lys Pro Ser Pro Ala Gly Thr Ala Lys Glu Leu Glu Pro Pro Ala 
1               5                   10                  15      


Pro Ala Arg Gly Glu Gln Arg Thr Ala Glu Pro Glu Gly Arg Trp Arg 
            20                  25                  30          


Glu Lys Gly Glu Ala Asp Thr Glu Arg Gln Arg Thr Arg Glu Arg Gln 
        35                  40                  45              


Glu Ala Thr Leu Ala Gly Leu Ala Glu Leu Glu Tyr Leu Arg Gln Arg 
    50                  55                  60                  


Gln Glu Leu Leu Val Arg Gly Ala Leu Arg Gly Ala Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Ala Pro Arg Ala Gly Glu Leu Leu Gly Glu Ala Ala Gln Arg 
                85                  90                  95      


Ser Arg Leu Glu Glu Lys Phe Leu Glu Glu Asn Ile Leu Leu Leu Arg 
            100                 105                 110         


Lys Gln Leu Asn Cys Leu Arg Arg Arg Asp Ala Gly Leu Leu Asn Gln 
        115                 120                 125             


Leu Gln Glu Leu Asp Lys Gln Ile Ser Asp Leu Arg Leu Asp Val Glu 
    130                 135                 140                 


Lys Thr Ser Glu Glu His Leu Glu Thr Asp Ser Arg Pro Ser Ser Gly 
145                 150                 155                 160 


Phe Tyr Glu Leu Ser Asp Gly Ala Ser Gly Ser Leu Ser Asn Ser Ser 
                165                 170                 175     


Asn Ser Val Phe Ser Glu Cys Leu Ser Ser Cys His Ser Ser Thr Cys 
            180                 185                 190         


Phe Cys Ser Pro Leu Glu Ala Thr Leu Ser Leu Ser Asp Gly Cys Pro 
        195                 200                 205             


Lys Ser Ala Asp Val Asn Pro Lys Tyr Gln Cys Asp Leu Val Ser Lys 
    210                 215                 220                 


Asn Gly Asn Asp Val Tyr Arg Tyr Pro Ser Pro Leu His Ala Val Ala 
225                 230                 235                 240 


Val Gln Ser Pro Met Phe Leu Leu Cys Leu Thr Gly Asn Pro Leu Arg 
                245                 250                 255     


Glu Glu Asp Arg Leu Gly Asn His Ala Ser Asp Ile Cys Gly Gly Ser 
            260                 265                 270         


Glu Leu Asp Ala Val Lys Thr Asp Ser Ser Leu Pro Ser Pro Ser Ser 
        275                 280                 285             


Leu Trp Ser Ala Ser His Pro Ser Ser Ser Lys Lys Met Asp Gly Tyr 
    290                 295                 300                 


Ile Leu Ser Leu Val Gln Lys Lys Thr His Pro Val Arg Thr Asn Lys 
305                 310                 315                 320 


Pro Arg Thr Ser Val Asn Ala Asp Pro Thr Lys Gly Leu Leu Arg Asn 
                325                 330                 335     


Gly Ser Val Cys Val Arg Ala Pro Gly Gly Val Ser Gln Gly Asn Ser 
            340                 345                 350         


Val Asn Leu Lys Asn Ser Lys Gln Ala Cys Leu Pro Ser Gly Gly Ile 
        355                 360                 365             


Pro Ser Leu Asn Asn Gly Thr Phe Ser Pro Pro Lys Gln Trp Ser Lys 
    370                 375                 380                 


Glu Ser Lys Ala Glu Gln Ala Glu Ser Lys Arg Val Pro Leu Pro Glu 
385                 390                 395                 400 


Gly Cys Pro Ser Gly Ala Ala Ser Asp Leu Gln Ser Lys His Leu Pro 
                405                 410                 415     


Lys Thr Ala Lys Pro Ala Ser Gln Glu His Ala Arg Cys Ser Ala Ile 
            420                 425                 430         


Gly Thr Gly Glu Ser Pro Lys Glu Ser Ala Gln Leu Ser Gly Ala Ser 
        435                 440                 445             


Pro Lys Glu Ser Pro Ser Arg Gly Pro Ala Pro Pro Gln Glu Asn Lys 
    450                 455                 460                 


Val Val Gln Pro Leu Lys Lys Met Ser Gln Lys Asn Ser Leu Gln Gly 
465                 470                 475                 480 


Val Pro Pro Ala Thr Pro Pro Leu Leu Ser Thr Ala Phe Pro Val Glu 
                485                 490                 495     


Glu Arg Pro Ala Leu Asp Phe Lys Ser Glu Gly Ser Ser Gln Ser Leu 
            500                 505                 510         


Glu Glu Ala His Leu Val Lys Ala Gln Phe Ile Pro Gly Gln Gln Pro 
        515                 520                 525             


Ser Val Arg Leu His Arg Gly His Arg Asn Met Gly Val Val Lys Asn 
    530                 535                 540                 


Ser Ser Leu Lys His Arg Gly Pro Ala Leu Gln Gly Leu Glu Asn Gly 
545                 550                 555                 560 


Leu Pro Thr Val Arg Glu Lys Thr Arg Ala Gly Ser Lys Lys Cys Arg 
                565                 570                 575     


Phe Pro Asp Asp Leu Asp Thr Asn Lys Lys Leu Lys Lys Ala Ser Ser 
            580                 585                 590         


Lys Gly Arg Lys Ser Gly Gly Gly Pro Glu Ala Gly Val Pro Gly Arg 
        595                 600                 605             


Pro Ala Gly Gly Gly His Arg Ala Gly Ser Arg Ala His Gly His Gly 
    610                 615                 620                 


Arg Glu Ala Val Val Ala Lys Pro Lys His Lys Arg Thr Asp Tyr Arg 
625                 630                 635                 640 


Arg Trp Lys Ser Ser Ala Glu Ile Ser Tyr Glu Glu Ala Leu Arg Arg 
                645                 650                 655     


Ala Arg Arg Gly Arg Arg Glu Asn Val Gly Leu Tyr Pro Ala Pro Val 
            660                 665                 670         


Pro Leu Pro Tyr Ala Ser Pro Tyr Ala Tyr Val Ala Ser Asp Ser Glu 
        675                 680                 685             


Tyr Ser Ala Glu Cys Glu Ser Leu Phe His Ser Thr Val Val Asp Thr 
    690                 695                 700                 


Ser Glu Asp Glu Gln Ser Asn Tyr Thr Thr Asn Cys Phe Gly Asp Ser 
705                 710                 715                 720 


Glu Ser Ser Val Ser Glu Gly Glu Phe Val Gly Glu Ser Thr Thr Thr 
                725                 730                 735     


Ser Asp Ser Glu Glu Ser Gly Gly Leu Ile Trp Ser Gln Phe Val Gln 
            740                 745                 750         


Thr Leu Pro Ile Gln Thr Val Thr Ala Pro Asp Leu His Asn His Pro 
        755                 760                 765             


Ala Lys Thr Phe Val Lys Ile Lys Ala Ser His Asn Leu Lys Lys Lys 
    770                 775                 780                 


Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys Leu Met Thr Thr Val 
785                 790                 795                 


<210>  2863
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DACT2__Homo_sapiens__NP_001273280

<400>  2863

Met Trp Thr Pro Gly Gly Pro Pro Gly Ser Ala Gly Trp Asp Arg Arg 
1               5                   10                  15      


Arg Leu Gly Ala Arg Leu Arg Ala Ala Phe Ala Gly Leu Gln Glu Leu 
            20                  25                  30          


Gln Gly Leu Arg Ala Thr Gln Gln Glu Arg Val Arg Gly Ala Leu Ala 
        35                  40                  45              


Leu Gln Pro Pro Pro Ala Pro Ala Ala Pro Cys Gly Pro His Gly Leu 
    50                  55                  60                  


His Gly Pro Glu Gln Gln Leu Glu Ala Ala Leu Ala Ala Leu Gln Glu 
65                  70                  75                  80  


Gln Leu Ser Arg Leu Arg Gln Gln Asp Ile Gly Leu Lys Thr His Leu 
                85                  90                  95      


Asp Gln Leu Asp Leu Gln Ile Ser Lys Leu Gln Leu Asp Val Gly Thr 
            100                 105                 110         


Ala Ser Gly Glu Ala Leu Asp Ser Asp Ser Arg Pro Ser Ser Gly Phe 
        115                 120                 125             


Tyr Glu Met Ser Asp Gly Gly Ser Cys Ser Leu Ser Thr Ser Cys Ala 
    130                 135                 140                 


Ser Val Cys Ser Asp His Ile Ser Pro Ser Leu Gly Ser Leu Leu Pro 
145                 150                 155                 160 


Val Ala Gln Ala His Lys Ala Arg Pro Ser Met Gly Asp Trp Arg Pro 
                165                 170                 175     


Arg Ser Val Asp Glu Thr Thr Val Pro Ala Trp Arg Pro Gln Ala Thr 
            180                 185                 190         


Glu Glu Gly Ala Arg Pro Pro Gly Ser Val Glu Asp Ala Gly Gln Pro 
        195                 200                 205             


Trp Gly Thr Phe Trp Pro Arg Pro Val Ser Thr Glu Leu Cys Asn Ala 
    210                 215                 220                 


Pro Gly Glu Leu Asp Met His Ala Pro Pro Ala Gly Cys Thr Ser Ser 
225                 230                 235                 240 


Ser Leu Thr Gly Val Gly Ser Gly Leu Arg Gly Lys Cys Gly Leu Cys 
                245                 250                 255     


Gly Cys Gln Leu Pro Phe Cys Ser Val Asn Thr Ser Ser Lys Thr Lys 
            260                 265                 270         


Ser Ser Gly Ile Ser Arg Gln Gln 
        275                 280 


<210>  2864
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DACT3__Homo_sapiens__NP_659493

<400>  2864

Met Ile Arg Ala Phe Ser Phe Pro Val Ser Pro Glu Arg Gly Arg Leu 
1               5                   10                  15      


Arg Gly Trp Leu Glu Gly Ser Leu Ala Gly Leu Cys Glu Leu His Trp 
            20                  25                  30          


Leu Arg Glu Arg Gln Glu Tyr Arg Val Gln Gln Ala Leu Arg Leu Ala 
        35                  40                  45              


Gln Pro Gly Met Gly Gly Ala Glu Ala Glu Asp Glu Glu Asp Ala Asp 
    50                  55                  60                  


Glu Asp Glu Asp Ala Ala Ala Ala Arg Arg Ala Ala Ala Ala Leu Glu 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Leu Pro Gly Leu Val Trp Asp Leu Gly Gln Gln 
                85                  90                  95      


Leu Gly Asp Leu Ser Leu Glu Ser Gly Gly Leu Glu Gln Glu Ser Gly 
            100                 105                 110         


Arg Ser Ser Gly Phe Tyr Glu Asp Pro Ser Ser Thr Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Pro Ser Thr Phe Cys Gly Asp Ser Gly Phe Ser Gly Ser Ser 
    130                 135                 140                 


Ser Tyr Gly Arg Leu Gly Pro Ser Glu Pro Arg Gly Ile Tyr Ala Ser 
145                 150                 155                 160 


Glu Arg Pro Lys Ser Leu Gly Asp Ala Ser Pro Ser Ala Pro Glu Val 
                165                 170                 175     


Val Gly Ala Arg Ala Ala Val Pro Arg Ser Phe Ser Ala Pro Tyr Pro 
            180                 185                 190         


Thr Ala Gly Gly Ser Ala Gly Pro Glu Ala Cys Ser Ser Ala Glu Arg 
        195                 200                 205             


Arg Ala Arg Ala Gly Pro Phe Leu Thr Pro Ser Pro Leu His Ala Val 
    210                 215                 220                 


Ala Met Arg Ser Pro Arg Pro Cys Gly Arg Pro Pro Thr Asp Ser Pro 
225                 230                 235                 240 


Asp Ala Gly Gly Ala Gly Arg Pro Leu Asp Gly Tyr Ile Ser Ala Leu 
                245                 250                 255     


Leu Arg Arg Arg Arg Arg Arg Gly Ala Gly Gln Pro Arg Thr Ser Pro 
            260                 265                 270         


Gly Gly Ala Asp Gly Gly Pro Arg Arg Gln Asn Ser Val Arg Gln Arg 
        275                 280                 285             


Pro Pro Asp Ala Ser Pro Ser Pro Gly Ser Ala Arg Pro Ala Arg Glu 
    290                 295                 300                 


Pro Ser Leu Glu Arg Val Gly Gly His Pro Thr Ser Pro Ala Ala Leu 
305                 310                 315                 320 


Ser Arg Ala Trp Ala Ser Ser Trp Glu Ser Glu Ala Ala Pro Glu Pro 
                325                 330                 335     


Ala Ala Pro Pro Ala Ala Pro Ser Pro Pro Asp Ser Pro Ala Glu Gly 
            340                 345                 350         


Arg Leu Val Lys Ala Gln Tyr Ile Pro Gly Ala Gln Ala Ala Thr Arg 
        355                 360                 365             


Gly Leu Pro Gly Arg Ala Ala Arg Arg Lys Pro Pro Pro Leu Thr Arg 
    370                 375                 380                 


Gly Arg Ser Val Glu Gln Ser Pro Pro Arg Glu Arg Pro Arg Ala Ala 
385                 390                 395                 400 


Gly Arg Arg Gly Arg Met Ala Glu Ala Ser Gly Arg Arg Gly Ser Pro 
                405                 410                 415     


Arg Ala Arg Lys Ala Ser Arg Ser Gln Ser Glu Thr Ser Leu Leu Gly 
            420                 425                 430         


Arg Ala Ser Ala Val Pro Ser Gly Pro Pro Lys Tyr Pro Thr Ala Glu 
        435                 440                 445             


Arg Glu Glu Pro Arg Pro Pro Arg Pro Arg Arg Gly Pro Ala Pro Thr 
    450                 455                 460                 


Leu Ala Ala Gln Ala Ala Gly Ser Cys Arg Arg Trp Arg Ser Thr Ala 
465                 470                 475                 480 


Glu Ile Asp Ala Ala Asp Gly Arg Arg Val Arg Pro Arg Ala Pro Ala 
                485                 490                 495     


Ala Arg Val Pro Gly Pro Gly Pro Ser Pro Ser Ala Pro Gln Arg Arg 
            500                 505                 510         


Leu Leu Tyr Gly Cys Ala Gly Ser Asp Ser Glu Cys Ser Ala Gly Arg 
        515                 520                 525             


Leu Gly Pro Leu Gly Arg Arg Gly Pro Ala Gly Gly Val Gly Gly Gly 
    530                 535                 540                 


Tyr Gly Glu Ser Glu Ser Ser Ala Ser Glu Gly Glu Ser Pro Ala Phe 
545                 550                 555                 560 


Ser Ser Ala Ser Ser Asp Ser Asp Gly Ser Gly Gly Leu Val Trp Pro 
                565                 570                 575     


Gln Gln Leu Val Ala Ala Thr Ala Ala Ser Gly Gly Gly Ala Gly Ala 
            580                 585                 590         


Gly Ala Pro Ala Gly Pro Ala Lys Val Phe Val Lys Ile Lys Ala Ser 
        595                 600                 605             


His Ala Leu Lys Lys Lys Ile Leu Arg Phe Arg Ser Gly Ser Leu Lys 
    610                 615                 620                 


Val Met Thr Thr Val 
625                 


<210>  2865
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAD1__Homo_sapiens__NP_001335

<400>  2865

Met Ser Ala Ser Val Val Ser Val Ile Ser Arg Phe Leu Glu Glu Tyr 
1               5                   10                  15      


Leu Ser Ser Thr Pro Gln Arg Leu Lys Leu Leu Asp Ala Tyr Leu Leu 
            20                  25                  30          


Tyr Ile Leu Leu Thr Gly Ala Leu Gln Phe Gly Tyr Cys Leu Leu Val 
        35                  40                  45              


Gly Thr Phe Pro Phe Asn Ser Phe Leu Ser Gly Phe Ile Ser Cys Val 
    50                  55                  60                  


Gly Ser Phe Ile Leu Ala Val Cys Leu Arg Ile Gln Ile Asn Pro Gln 
65                  70                  75                  80  


Asn Lys Ala Asp Phe Gln Gly Ile Ser Pro Glu Arg Ala Phe Ala Asp 
                85                  90                  95      


Phe Leu Phe Ala Ser Thr Ile Leu His Leu Val Val Met Asn Phe Val 
            100                 105                 110         


Gly 
    


<210>  2866
<211>  895
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAG1__Homo_sapiens__NP_001171113

<400>  2866

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Trp Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  2867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAND5__Homo_sapiens__NP_689867

<400>  2867

Met Leu Leu Gly Gln Leu Ser Thr Leu Leu Cys Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Pro Thr Gly Ser Gly Arg Pro Glu Pro Gln Ser Pro Arg Pro Gln 
            20                  25                  30          


Ser Trp Ala Ala Ala Asn Gln Thr Trp Ala Leu Gly Pro Gly Ala Leu 
        35                  40                  45              


Pro Pro Leu Val Pro Ala Ser Ala Leu Gly Ser Trp Lys Ala Phe Leu 
    50                  55                  60                  


Gly Leu Gln Lys Ala Arg Gln Leu Gly Met Gly Arg Leu Gln Arg Gly 
65                  70                  75                  80  


Gln Asp Glu Val Ala Ala Val Thr Leu Pro Leu Asn Pro Gln Glu Val 
                85                  90                  95      


Ile Gln Gly Met Cys Lys Ala Val Pro Phe Val Gln Val Phe Ser Arg 
            100                 105                 110         


Pro Gly Cys Ser Ala Ile Arg Leu Arg Asn His Leu Cys Phe Gly His 
        115                 120                 125             


Cys Ser Ser Leu Tyr Ile Pro Gly Ser Asp Pro Thr Pro Leu Val Leu 
    130                 135                 140                 


Cys Asn Ser Cys Met Pro Ala Arg Lys Arg Trp Ala Pro Val Val Leu 
145                 150                 155                 160 


Trp Cys Leu Thr Gly Ser Ser Ala Ser Arg Arg Arg Val Lys Ile Ser 
                165                 170                 175     


Thr Met Leu Ile Glu Gly Cys His Cys Ser Pro Lys Ala 
            180                 185                 


<210>  2868
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAOA__Homo_sapiens__NP_001155284

<400>  2868

Met Arg Thr Ala Ile Trp Lys Trp His Arg Gly Ile Tyr Arg Asp His 
1               5                   10                  15      


Tyr Val Leu Gly Ser Leu Thr Phe Leu Ser Pro Met Gln Arg Ala Gly 
            20                  25                  30          


Thr Ser Asn Gln Trp Asn Met Gly Lys Val Met Thr Leu Asp Ser Gly 
        35                  40                  45              


Asp Glu Val Thr Phe His Lys Thr Trp Pro Thr Glu Thr Gly Ser Pro 
    50                  55                  60                  


Tyr Arg Leu Glu Glu Val Ser Ser His Val Gly Lys Val Phe Met Ala 
65                  70                  75                  80  


Arg Asn Tyr Glu Phe Leu Ala Tyr Glu Ala Ser Lys Asp Arg Arg Gln 
                85                  90                  95      


Pro Leu Glu Arg Met Trp Thr Cys Asn Tyr Asn Gln Gln Lys Asp Gln 
            100                 105                 110         


Ser Cys Asn His Lys Glu Ile Thr Ser Thr Lys Ala Glu 
        115                 120                 125 


<210>  2869
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAO__Homo_sapiens__XP_011536307

<400>  2869

Met Arg Val Val Val Ile Gly Ala Gly Val Ile Gly Leu Ser Thr Ala 
1               5                   10                  15      


Leu Cys Ile His Glu Arg Tyr His Ser Val Leu Gln Pro Leu Asp Ile 
            20                  25                  30          


Lys Val Tyr Ala Asp Arg Phe Thr Pro Leu Thr Thr Thr Asp Val Ala 
        35                  40                  45              


Ala Gly Leu Trp Gln Pro Tyr Leu Ser Asp Pro Asn Asn Pro Gln Glu 
    50                  55                  60                  


Ala Asp Trp Ser Gln Gln Thr Phe Asp Tyr Leu Leu Ser His Val His 
65                  70                  75                  80  


Ser Pro Asn Ala Glu Asn Leu Gly Leu Phe Leu Ile Ser Gly Tyr Asn 
                85                  90                  95      


Leu Phe His Glu Ala Ile Pro Asp Pro Ser Trp Lys Asp Thr Val Leu 
            100                 105                 110         


Gly Phe Arg Lys Leu Thr Pro Arg Glu Leu Asp Met Phe Pro Asp Tyr 
        115                 120                 125             


Gly Tyr Gly Trp Phe His Thr Ser Leu Ile Leu Glu Gly Lys Asn Tyr 
    130                 135                 140                 


Leu Gln Trp Leu Thr Glu Arg Leu Thr Glu Arg Gly Val Lys Phe Phe 
145                 150                 155                 160 


Gln Arg Lys Val Glu Ser Phe Glu Glu Val Ala Arg Glu Gly Ala Asp 
                165                 170                 175     


Val Ile Val Asn Cys Thr Gly Val Trp Ala Gly Ala Leu Gln Arg Asp 
            180                 185                 190         


Pro Leu Leu Gln Pro Gly Arg Gly Gln Ile Met Lys Val Asp Ala Pro 
        195                 200                 205             


Trp Met Lys His Phe Ile Leu Thr His Asp Pro Glu Arg Gly Ile Tyr 
    210                 215                 220                 


Asn Ser Pro Tyr Ile Ile Pro Gly Thr Gln Thr Val Thr Leu Gly Gly 
225                 230                 235                 240 


Ile Phe Gln Leu Gly Asn Trp Ser Glu Leu Asn Asn Ile Gln Asp His 
                245                 250                 255     


Asn Thr Ile Trp Glu Gly Cys Cys Arg Leu Glu Pro Thr Leu Lys Asn 
            260                 265                 270         


Ala Arg Ile Ile Gly Glu Arg Thr Gly Phe Arg Pro Val Arg Pro Gln 
        275                 280                 285             


Ile Arg Leu Glu Arg Glu Gln Leu Arg Thr Gly Pro Ser Asn Thr Glu 
    290                 295                 300                 


Val Ile His Asn Tyr Gly His Gly Gly Tyr Gly Leu Thr Ile His Trp 
305                 310                 315                 320 


Gly Cys Ala Leu Glu Ala Ala Lys Leu Phe Gly Arg Ile Leu Glu Glu 
                325                 330                 335     


Lys Lys Leu Ser Arg Met Pro Pro Ser His Leu 
            340                 345         


<210>  2870
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAP3__Homo_sapiens__NP_001186778

<400>  2870

Met Met Leu Lys Gly Ile Thr Arg Leu Ile Ser Arg Ile His Lys Leu 
1               5                   10                  15      


Asp Pro Gly Arg Phe Leu His Met Gly Thr Gln Ala Arg Gln Ser Ile 
            20                  25                  30          


Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile 
        35                  40                  45              


Ser Arg Thr Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu 
    50                  55                  60                  


Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Thr Val Phe Pro 
65                  70                  75                  80  


His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Thr Phe Ser Glu 
                85                  90                  95      


Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu 
            100                 105                 110         


Lys Asn Thr Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu Tyr Gly 
        115                 120                 125             


Glu Lys Gly Thr Gly Lys Thr Leu Ser Leu Cys His Val Ile His Phe 
    130                 135                 140                 


Cys Ala Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu 
145                 150                 155                 160 


Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln 
                165                 170                 175     


Arg Phe Asp Gln Pro Leu Glu Ala Ser Thr Trp Leu Lys Asn Phe Lys 
            180                 185                 190         


Thr Thr Asn Glu Arg Phe Leu Asn Gln Ile Lys Val Gln Glu Lys Tyr 
        195                 200                 205             


Val Trp Asn Lys Arg Glu Ser Thr Glu Lys Gly Ser Pro Leu Gly Glu 
    210                 215                 220                 


Val Val Glu Gln Gly Ile Thr Arg Val Arg Asn Ala Thr Asp Ala Val 
225                 230                 235                 240 


Gly Ile Val Leu Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe 
                245                 250                 255     


His Leu Leu Val Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Thr 
            260                 265                 270         


Thr Leu Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala 
        275                 280                 285             


Leu Val His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly 
    290                 295                 300                 


Ala Ile Val Ser Ala Leu Ser Gln Thr Gly Ser Leu Phe Lys Pro Arg 
305                 310                 315                 320 


Lys Ala Tyr Leu Pro Gln Glu Leu Leu Gly Lys Glu Gly Phe Asp Ala 
                325                 330                 335     


Leu Asp Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr Asn Pro Lys Glu 
            340                 345                 350         


Phe Glu Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His 
        355                 360                 365             


Glu Lys Ala Pro Thr Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser 
    370                 375                 380                 


Asn Ala Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu 
385                 390                 395             


<210>  2871
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAP__Homo_sapiens__NP_001278892

<400>  2871

Met Ser Ser Pro Pro Glu Gly Lys Leu Glu Thr Lys Ala Gly His Pro 
1               5                   10                  15      


Pro Ala Val Lys Ala Gly Gly Met Arg Ile Val Gln Lys His Pro His 
            20                  25                  30          


Thr Gly Asp Thr Lys Glu Glu Lys Asp Lys Asp Asp Gln Glu Trp Glu 
        35                  40                  45              


Ser Pro Arg Val Thr Lys Ile Ser Pro Arg Arg Leu Arg Arg Trp Leu 
    50                  55                  60                  


Thr Arg Ser Arg Met Pro Pro Trp Thr Ser Ile Leu Pro Gln Glu Pro 
65                  70                  75                  80  


Ser Thr Ser Ser Ser His Ala Ser Glu Pro Gly Val His Gln Pro Ala 
                85                  90                  95      


Pro Trp Pro Arg Leu Cys Cys Thr Trp Tyr Phe Pro Asp Arg Glu Asn 
            100                 105                 110         


Gln Gln Phe Arg Pro Asn Pro Thr Leu Leu Gly Asn Leu Arg Gln Asn 
        115                 120                 125             


Gln Val Leu Cys Pro Leu Pro Tyr Ile Ser Ile Phe Lys Thr Arg Asn 
    130                 135                 140                 


Ser Ser Ser Pro Asn Leu Val Tyr Gly Glu Ser Gly Trp Met Ser Phe 
145                 150                 155                 160 


Glu Asp His Cys Ala Pro Arg Gly Ala Ile Ser Arg Ile Cys Gln Asp 
                165                 170                 175     


Pro Arg Lys Ile Leu Ala Leu Val Leu Phe Gln Gln Ser Pro Asp Val 
            180                 185                 190         


Leu Val Tyr Gly Leu Lys Asn Lys Lys Ala His Ile 
        195                 200                 


<210>  2872
<211>  1430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAPK1__Homo_sapiens__NP_004929

<400>  2872

Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 
            20                  25                  30          


Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 
    50                  55                  60                  


Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His 
65                  70                  75                  80  


Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         


Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 
        115                 120                 125             


Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 
145                 150                 155                 160 


Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu 
    210                 215                 220                 


Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His 
            260                 265                 270         


Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala 
        275                 280                 285             


Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 
    290                 295                 300                 


Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 
305                 310                 315                 320 


Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr 
                325                 330                 335     


Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 
            340                 345                 350         


Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 
        355                 360                 365             


Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu 
    370                 375                 380                 


Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 
385                 390                 395                 400 


Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 
                405                 410                 415     


Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser 
            420                 425                 430         


Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 
        435                 440                 445             


Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 
    450                 455                 460                 


Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Thr 
465                 470                 475                 480 


Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 
                485                 490                 495     


Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 
            500                 505                 510         


Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 
        515                 520                 525             


Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 
    530                 535                 540                 


His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 
545                 550                 555                 560 


Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 
                565                 570                 575     


Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 
            580                 585                 590         


Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 
        595                 600                 605             


Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 
    610                 615                 620                 


Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Thr 
625                 630                 635                 640 


Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 
                645                 650                 655     


His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His Arg Gly 
            660                 665                 670         


Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro Arg Ile 
        675                 680                 685             


Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr Leu Val 
    690                 695                 700                 


Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 
705                 710                 715                 720 


Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 
                725                 730                 735     


Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 
            740                 745                 750         


Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 
        755                 760                 765             


Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His His Pro 
    770                 775                 780                 


His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile Gln Asn 
785                 790                 795                 800 


Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe Ser Gly 
                805                 810                 815     


Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn Asp Pro 
            820                 825                 830         


Thr Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr Glu Ile 
        835                 840                 845             


Gln Leu Asn Gln Val Ile Phe Trp Leu Ser Phe Leu Lys Ser Leu Val 
    850                 855                 860                 


Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu 
865                 870                 875                 880 


Gln Val Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val Pro Arg 
                885                 890                 895     


Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu Leu Lys 
            900                 905                 910         


Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu 
        915                 920                 925             


Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu 
    930                 935                 940                 


Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro 
945                 950                 955                 960 


Pro Met Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro Ser Trp 
                965                 970                 975     


Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val 
            980                 985                 990         


Tyr Asp Val Gln Asp Gln Leu Asn  Pro Leu Ala Ser Glu  Glu Asp Leu 
        995                 1000                 1005             


Arg Arg  Ile Ala Gln Gln Leu  His Ser Thr Gly Glu  Ile Asn Ile 
    1010                 1015                 1020             


Met Gln  Ser Glu Thr Val Gln  Asp Val Leu Leu Leu  Asp Pro Arg 
    1025                 1030                 1035             


Trp Leu  Cys Thr Asn Val Leu  Gly Lys Leu Leu Ser  Val Glu Thr 
    1040                 1045                 1050             


Pro Arg  Ala Leu His His Tyr  Arg Gly Arg Tyr Thr  Val Glu Asp 
    1055                 1060                 1065             


Ile Gln  Arg Leu Val Pro Asp  Ser Asp Val Glu Glu  Leu Leu Gln 
    1070                 1075                 1080             


Ile Leu  Asp Ala Met Asp Ile  Cys Ala Arg Asp Leu  Ser Ser Gly 
    1085                 1090                 1095             


Thr Met  Val Asp Val Pro Ala  Leu Ile Lys Thr Asp  Asn Leu His 
    1100                 1105                 1110             


Arg Ser  Trp Ala Asp Glu Glu  Asp Glu Val Met Val  Tyr Gly Gly 
    1115                 1120                 1125             


Val Arg  Ile Val Pro Val Glu  His Leu Thr Pro Phe  Pro Cys Gly 
    1130                 1135                 1140             


Ile Phe  His Lys Val Gln Val  Asn Leu Cys Arg Trp  Ile His Gln 
    1145                 1150                 1155             


Gln Ser  Thr Glu Gly Asp Ala  Asp Ile Arg Leu Trp  Val Asn Gly 
    1160                 1165                 1170             


Cys Lys  Leu Ala Asn Arg Gly  Ala Glu Leu Leu Val  Leu Leu Val 
    1175                 1180                 1185             


Asn His  Gly Gln Gly Ile Glu  Val Gln Val Arg Gly  Leu Glu Thr 
    1190                 1195                 1200             


Glu Lys  Ile Lys Cys Cys Leu  Leu Leu Asp Ser Val  Cys Ser Thr 
    1205                 1210                 1215             


Ile Glu  Asn Val Met Ala Thr  Thr Leu Pro Gly Leu  Leu Thr Val 
    1220                 1225                 1230             


Lys His  Tyr Leu Ser Pro Gln  Gln Leu Arg Glu His  His Glu Pro 
    1235                 1240                 1245             


Val Met  Ile Tyr Gln Pro Arg  Asp Phe Phe Arg Ala  Gln Thr Leu 
    1250                 1255                 1260             


Lys Glu  Thr Ser Leu Thr Asn  Thr Met Gly Gly Tyr  Lys Glu Ser 
    1265                 1270                 1275             


Phe Ser  Ser Ile Met Cys Phe  Gly Cys His Asp Val  Tyr Ser Gln 
    1280                 1285                 1290             


Ala Ser  Leu Gly Met Asp Ile  His Ala Ser Asp Leu  Asn Leu Leu 
    1295                 1300                 1305             


Thr Arg  Arg Lys Leu Ser Arg  Leu Leu Asp Pro Pro  Asp Pro Leu 
    1310                 1315                 1320             


Gly Lys  Asp Trp Cys Leu Leu  Ala Met Asn Leu Gly  Leu Pro Asp 
    1325                 1330                 1335             


Leu Val  Ala Lys Tyr Asn Thr  Ser Asn Gly Ala Pro  Lys Asp Phe 
    1340                 1345                 1350             


Leu Pro  Ser Pro Leu His Ala  Leu Leu Arg Glu Trp  Thr Thr Tyr 
    1355                 1360                 1365             


Pro Glu  Ser Thr Val Gly Thr  Leu Met Ser Lys Leu  Arg Glu Leu 
    1370                 1375                 1380             


Gly Arg  Arg Asp Ala Ala Asp  Phe Leu Leu Lys Ala  Ser Ser Val 
    1385                 1390                 1395             


Phe Lys  Ile Asn Leu Asp Gly  Asn Gly Gln Glu Ala  Tyr Ala Ser 
    1400                 1405                 1410             


Ser Cys  Asn Ser Gly Thr Ser  Tyr Asn Ser Ile Ser  Ser Val Val 
    1415                 1420                 1425             


Ser Arg  
    1430 


<210>  2873
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAPK2__Homo_sapiens__NP_055141

<400>  2873

Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15      


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
            20                  25                  30          


Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Thr Gly Leu Glu 
        35                  40                  45              


Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
    50                  55                  60                  


Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Val Ser Ile Leu Arg Gln 
65                  70                  75                  80  


Val Leu His His Asn Val Ile Thr Leu His Asp Val Tyr Glu Asn Arg 
                85                  90                  95      


Thr Asp Val Val Leu Ile Leu Glu Leu Val Ser Gly Gly Glu Leu Phe 
            100                 105                 110         


Asp Phe Leu Ala Gln Lys Glu Ser Leu Ser Glu Glu Glu Ala Thr Ser 
        115                 120                 125             


Phe Ile Lys Gln Ile Leu Asp Gly Val Asn Tyr Leu His Thr Lys Lys 
    130                 135                 140                 


Ile Ala His Phe Asp Leu Lys Pro Glu Asn Ile Met Leu Leu Asp Lys 
145                 150                 155                 160 


Asn Ile Pro Ile Pro His Ile Lys Leu Ile Asp Phe Gly Leu Ala His 
                165                 170                 175     


Glu Ile Glu Asp Gly Val Glu Phe Lys Asn Ile Phe Gly Thr Pro Glu 
            180                 185                 190         


Phe Val Ala Pro Glu Ile Val Asn Tyr Glu Pro Leu Gly Leu Glu Ala 
        195                 200                 205             


Asp Met Trp Ser Ile Gly Val Ile Thr Tyr Ile Leu Leu Ser Gly Ala 
    210                 215                 220                 


Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu Thr Leu Ala Asn Ile Thr 
225                 230                 235                 240 


Ala Val Ser Tyr Asp Phe Asp Glu Glu Phe Phe Ser Gln Thr Ser Glu 
                245                 250                 255     


Leu Ala Lys Asp Phe Ile Arg Lys Leu Leu Val Lys Glu Thr Arg Lys 
            260                 265                 270         


Arg Leu Thr Ile Gln Glu Ala Leu Arg His Pro Trp Ile Thr Pro Val 
        275                 280                 285             


Asp Asn Gln Gln Ala Met Val Arg Arg Glu Ser Val Val Asn Leu Glu 
    290                 295                 300                 


Asn Phe Arg Lys Gln Tyr Val Arg Arg Arg Trp Lys Leu Ser Phe Ser 
305                 310                 315                 320 


Ile Val Ser Leu Cys Asn His Leu Thr Arg Ser Leu Met Lys Lys Val 
                325                 330                 335     


His Leu Arg Pro Asp Glu Asp Leu Arg Asn Cys Glu Ser Asp Thr Glu 
            340                 345                 350         


Glu Asp Ile Ala Arg Arg Lys Ala Leu His Pro Arg Arg Arg Ser Ser 
        355                 360                 365             


Thr Ser 
    370 


<210>  2874
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAPK3__Homo_sapiens__XP_005259565

<400>  2874

Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly 
1               5                   10                  15      


Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln 
            20                  25                  30          


Lys Gly Thr Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              


Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu 
    50                  55                  60                  


Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His 
65                  70                  75                  80  


Asp Ile Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         


Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His 
        115                 120                 125             


Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile 
145                 150                 155                 160 


Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn 
                165                 170                 175     


Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         


Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             


Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu 
    210                 215                 220                 


Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr 
225                 230                 235                 240 


Phe Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     


Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His 
            260                 265                 270         


Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser 
        275                 280                 285             


Gly Arg Lys Pro Glu Arg Arg Arg Leu Lys Thr Thr Arg Leu Lys Glu 
    290                 295                 300                 


Tyr Thr Ile Lys Ser His Ser Ser Leu Pro Pro Asn Asn Ser Tyr Ala 
305                 310                 315                 320 


Asp Phe Glu Arg Phe Ser Lys Val Leu Glu Glu Ala Ala Ala Ala Glu 
                325                 330                 335     


Glu Gly Leu Arg Glu Leu Gln Arg Ser Arg Arg Leu Cys His Glu Asp 
            340                 345                 350         


Val Glu Ala Leu Ala Ala Ile Tyr Glu Glu Lys Glu Ala Trp Tyr Arg 
        355                 360                 365             


Glu Glu Ser Asp Ser Leu Gly Gln Asp Leu Arg Arg Leu Arg Gln Glu 
    370                 375                 380                 


Leu Leu Lys Thr Glu Ala Leu Lys Arg Gln Ala Gln Glu Glu Ala Lys 
385                 390                 395                 400 


Gly Ala Leu Leu Gly Thr Ser Gly Leu Lys Arg Arg Phe Ser Arg Leu 
                405                 410                 415     


Glu Asn Arg Tyr Glu Ala Leu Ala Lys Gln Val Ala Ser Glu Met Arg 
            420                 425                 430         


Phe Val Gln Asp Leu Val Arg Ala Leu Glu Gln Glu Lys Leu Gln Gly 
        435                 440                 445             


Val Glu Cys Gly Leu Arg 
    450                 


<210>  2875
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DARS2__Homo_sapiens__NP_060592

<400>  2875

Met Tyr Phe Pro Ser Trp Leu Ser Gln Leu Tyr Arg Gly Leu Ser Arg 
1               5                   10                  15      


Pro Ile Arg Arg Thr Thr Gln Pro Ile Trp Gly Ser Leu Tyr Arg Ser 
            20                  25                  30          


Leu Leu Gln Ser Ser Gln Arg Arg Ile Pro Glu Phe Ser Ser Phe Val 
        35                  40                  45              


Val Arg Thr Asn Thr Cys Gly Glu Leu Arg Ser Ser His Leu Gly Gln 
    50                  55                  60                  


Glu Val Thr Leu Cys Gly Trp Ile Gln Tyr Arg Arg Gln Asn Thr Phe 
65                  70                  75                  80  


Leu Val Leu Arg Asp Phe Asp Gly Leu Val Gln Val Ile Ile Pro Gln 
                85                  90                  95      


Asp Glu Ser Ala Ala Ser Val Lys Lys Ile Leu Cys Glu Ala Pro Val 
            100                 105                 110         


Glu Ser Val Val Gln Val Ser Gly Thr Val Ile Ser Arg Pro Ala Gly 
        115                 120                 125             


Gln Glu Asn Pro Lys Met Pro Thr Gly Glu Ile Glu Ile Lys Val Lys 
    130                 135                 140                 


Thr Ala Glu Leu Leu Asn Ala Cys Lys Lys Leu Pro Phe Glu Ile Lys 
145                 150                 155                 160 


Asn Phe Val Lys Lys Thr Glu Ala Leu Arg Leu Gln Tyr Arg Tyr Leu 
                165                 170                 175     


Asp Leu Arg Ser Phe Gln Met Gln Tyr Asn Leu Arg Leu Arg Ser Gln 
            180                 185                 190         


Met Val Met Lys Met Arg Glu Tyr Leu Cys Asn Leu His Gly Phe Val 
        195                 200                 205             


Asp Ile Glu Thr Pro Thr Leu Phe Lys Arg Thr Pro Gly Gly Ala Lys 
    210                 215                 220                 


Glu Phe Leu Val Pro Ser Arg Glu Pro Gly Lys Phe Tyr Ser Leu Pro 
225                 230                 235                 240 


Gln Ser Pro Gln Gln Phe Lys Gln Leu Leu Met Val Gly Gly Leu Asp 
                245                 250                 255     


Arg Tyr Phe Gln Val Ala Arg Cys Tyr Arg Asp Glu Gly Ser Arg Pro 
            260                 265                 270         


Asp Arg Gln Pro Glu Phe Thr Gln Ile Asp Ile Glu Met Ser Phe Val 
        275                 280                 285             


Asp Gln Thr Gly Ile Gln Ser Leu Ile Glu Gly Leu Leu Gln Tyr Ser 
    290                 295                 300                 


Trp Pro Asn Asp Lys Asp Pro Val Val Val Pro Phe Pro Thr Met Thr 
305                 310                 315                 320 


Phe Ala Glu Val Leu Ala Thr Tyr Gly Thr Asp Lys Pro Asp Thr Arg 
                325                 330                 335     


Phe Gly Met Lys Ile Ile Asp Ile Ser Asp Val Phe Arg Asn Thr Glu 
            340                 345                 350         


Ile Gly Phe Leu Gln Asp Ala Leu Ser Lys Pro His Gly Thr Val Lys 
        355                 360                 365             


Ala Ile Cys Ile Pro Glu Gly Ala Lys Tyr Leu Lys Arg Lys Asp Ile 
    370                 375                 380                 


Glu Ser Ile Arg Asn Phe Ala Ala Asp His Phe Asn Gln Glu Ile Leu 
385                 390                 395                 400 


Pro Val Phe Leu Asn Ala Asn Arg Asn Trp Asn Ser Pro Val Ala Asn 
                405                 410                 415     


Phe Ile Met Glu Ser Gln Arg Leu Glu Leu Ile Arg Leu Met Glu Thr 
            420                 425                 430         


Gln Glu Glu Asp Val Val Leu Leu Thr Ala Gly Glu His Asn Lys Ala 
        435                 440                 445             


Cys Ser Leu Leu Gly Lys Leu Arg Leu Glu Cys Ala Asp Leu Leu Glu 
    450                 455                 460                 


Thr Arg Gly Val Val Leu Arg Asp Pro Thr Leu Phe Ser Phe Leu Trp 
465                 470                 475                 480 


Val Val Asp Phe Pro Leu Phe Leu Pro Lys Glu Glu Asn Pro Arg Glu 
                485                 490                 495     


Leu Glu Ser Ala His His Pro Phe Thr Ala Pro His Pro Ser Asp Ile 
            500                 505                 510         


His Leu Leu Tyr Thr Glu Pro Lys Lys Ala Arg Ser Gln His Tyr Asp 
        515                 520                 525             


Leu Val Leu Asn Gly Asn Glu Ile Gly Gly Gly Ser Ile Arg Ile His 
    530                 535                 540                 


Asn Ala Glu Leu Gln Arg Tyr Ile Leu Ala Thr Leu Leu Lys Glu Asp 
545                 550                 555                 560 


Val Lys Met Leu Ser His Leu Leu Gln Ala Leu Asp Tyr Gly Ala Pro 
                565                 570                 575     


Pro His Gly Gly Ile Ala Leu Gly Leu Asp Arg Leu Ile Cys Leu Val 
            580                 585                 590         


Thr Gly Ser Pro Ser Ile Arg Asp Val Ile Ala Phe Pro Lys Ser Phe 
        595                 600                 605             


Arg Gly His Asp Leu Met Ser Asn Thr Pro Asp Ser Val Pro Pro Glu 
    610                 615                 620                 


Glu Leu Lys Pro Tyr His Ile Arg Val Ser Lys Pro Thr Asp Ser Lys 
625                 630                 635                 640 


Ala Glu Arg Ala His 
                645 


<210>  2876
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DARS__Homo_sapiens__NP_001280241

<400>  2876

Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val 
1               5                   10                  15      


Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln 
            20                  25                  30          


Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala 
        35                  40                  45              


Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro Glu Ala 
    50                  55                  60                  


Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr Arg Leu 
65                  70                  75                  80  


Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala Val Phe 
                85                  90                  95      


Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn 
            100                 105                 110         


Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser 
        115                 120                 125             


Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala 
    130                 135                 140                 


Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala 
145                 150                 155                 160 


Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp 
                165                 170                 175     


Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu 
            180                 185                 190         


Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu Glu Ile Ala Asp 
        195                 200                 205             


Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu 
    210                 215                 220                 


Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu 
225                 230                 235                 240 


Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg 
                245                 250                 255     


Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn 
            260                 265                 270         


Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe 
        275                 280                 285             


Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met 
    290                 295                 300                 


Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met 
305                 310                 315                 320 


Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln 
                325                 330                 335     


Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu Glu Lys Ile 
            340                 345                 350         


Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly 
        355                 360                 365             


Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu Gly Leu His 
    370                 375                 380                 


Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr 
385                 390                 395                 400 


Pro 
    


<210>  2877
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAW1__Homo_sapiens__NP_849143

<400>  2877

Met Lys Leu Lys Ser Leu Leu Leu Arg Tyr Tyr Pro Pro Gly Ile Met 
1               5                   10                  15      


Leu Glu Tyr Glu Lys His Gly Glu Leu Lys Thr Lys Ser Ile Asp Leu 
            20                  25                  30          


Leu Asp Leu Gly Pro Ser Thr Asp Val Ser Ala Leu Val Glu Glu Ile 
        35                  40                  45              


Gln Lys Ala Glu Pro Leu Leu Thr Ala Ser Arg Thr Glu Gln Val Lys 
    50                  55                  60                  


Leu Leu Ile Gln Arg Leu Gln Glu Lys Leu Gly Gln Asn Ser Asn His 
65                  70                  75                  80  


Thr Phe Tyr Leu Phe Lys Val Leu Lys Ala His Ile Leu Pro Leu Thr 
                85                  90                  95      


Asn Val Ala Leu Asn Lys Ser Gly Ser Cys Phe Ile Thr Gly Ser Tyr 
            100                 105                 110         


Asp Arg Thr Cys Lys Leu Trp Asp Thr Ala Ser Gly Glu Glu Leu Asn 
        115                 120                 125             


Thr Leu Glu Gly His Arg Asn Val Val Tyr Ala Ile Ala Phe Asn Asn 
    130                 135                 140                 


Pro Tyr Gly Asp Lys Ile Ala Thr Gly Ser Phe Asp Lys Thr Cys Lys 
145                 150                 155                 160 


Leu Trp Ser Val Glu Thr Gly Lys Cys Tyr His Thr Phe Arg Gly His 
                165                 170                 175     


Thr Ala Glu Ile Val Cys Leu Ser Phe Asn Pro Gln Ser Thr Leu Val 
            180                 185                 190         


Ala Thr Gly Ser Met Asp Thr Thr Ala Lys Leu Trp Asp Ile Gln Asn 
        195                 200                 205             


Gly Glu Glu Val Tyr Thr Leu Arg Gly His Ser Ala Glu Ile Ile Ser 
    210                 215                 220                 


Leu Ser Phe Asn Thr Ser Gly Asp Arg Ile Ile Thr Gly Ser Phe Asp 
225                 230                 235                 240 


His Thr Val Val Val Trp Asp Ala Asp Thr Gly Arg Lys Val Asn Ile 
                245                 250                 255     


Leu Ile Gly His Cys Ala Glu Ile Ser Ser Ala Ser Phe Asn Trp Asp 
            260                 265                 270         


Cys Ser Leu Ile Leu Thr Gly Ser Met Asp Lys Thr Cys Lys Leu Trp 
        275                 280                 285             


Asp Ala Thr Asn Gly Lys Cys Val Ala Thr Leu Thr Gly His Asp Asp 
    290                 295                 300                 


Glu Ile Leu Asp Ser Cys Phe Asp Tyr Thr Gly Lys Leu Ile Ala Thr 
305                 310                 315                 320 


Ala Ser Ala Asp Gly Thr Ala Arg Ile Phe Ser Ala Ala Thr Arg Lys 
                325                 330                 335     


Cys Ile Ala Lys Leu Glu Gly His Glu Gly Glu Ile Ser Lys Ile Ser 
            340                 345                 350         


Phe Asn Pro Gln Gly Asn His Leu Leu Thr Gly Ser Ser Asp Lys Thr 
        355                 360                 365             


Ala Arg Ile Trp Asp Ala Gln Thr Gly Gln Cys Leu Gln Val Leu Glu 
    370                 375                 380                 


Gly His Thr Asp Glu Ile Phe Ser Cys Ala Phe Asn Tyr Lys Gly Asn 
385                 390                 395                 400 


Ile Val Ile Thr Gly Ser Lys Asp Asn Thr Cys Arg Ile Trp Arg 
                405                 410                 415 


<210>  2878
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAXX__Homo_sapiens__NP_001135442

<400>  2878

Met Arg Gly Ser Glu Asn Cys Gly Glu Gly Arg Leu Glu Arg Arg Phe 
1               5                   10                  15      


Leu Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp Glu Ala Ala Ala 
            20                  25                  30          


Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala Ser Pro Gly Ala 
        35                  40                  45              


Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg Gly Ser Ser Ser 
    50                  55                  60                  


Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu Lys Leu Phe Glu 
65                  70                  75                  80  


Glu Phe Leu Glu Leu Cys Lys Met Gln Thr Ala Asp His Pro Glu Val 
                85                  90                  95      


Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His Ser Leu Phe Leu 
            100                 105                 110         


Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val Leu Ser Arg Ala 
        115                 120                 125             


Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn Glu Leu Cys Thr 
    130                 135                 140                 


Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn Leu Ala Pro Ala 
145                 150                 155                 160 


Ala Thr Thr Ser Asn Glu Pro Ser Gly Asn Asn Pro Pro Thr His Leu 
                165                 170                 175     


Ser Leu Asp Pro Thr Asn Ala Glu Asn Thr Ala Ser Gln Ser Pro Arg 
            180                 185                 190         


Thr Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu Gln Leu Leu Ala 
        195                 200                 205             


Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys Glu Leu Asp Leu 
    210                 215                 220                 


Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln Glu Ala Arg Leu 
225                 230                 235                 240 


Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys Glu Leu Lys Asp 
                245                 250                 255     


Cys Ser Ser Leu Thr Gly Arg Val Ile Glu Gln Arg Ile Pro Tyr Arg 
            260                 265                 270         


Gly Thr Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu Arg Leu Ile Asn 
        275                 280                 285             


Lys Pro Gly Pro Asp Thr Phe Pro Asp Tyr Gly Asp Val Leu Arg Ala 
    290                 295                 300                 


Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu Pro Arg Gln Gln 
305                 310                 315                 320 


Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val Gly Ile Arg Leu 
                325                 330                 335     


Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe Gly Cys His Leu 
            340                 345                 350         


Thr Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu Ser Asp Pro Val 
        355                 360                 365             


Leu Ala Arg Arg Leu Arg Glu Asn Arg Ser Leu Ala Met Ser Arg Leu 
    370                 375                 380                 


Asp Glu Val Ile Ser Lys Tyr Ala Met Leu Gln Asp Lys Ser Glu Glu 
385                 390                 395                 400 


Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly Thr Ser Ser His 
                405                 410                 415     


Ser Ala Asp Thr Pro Glu Ala Ser Leu Asp Ser Gly Glu Gly Pro Ser 
            420                 425                 430         


Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg Ala Glu Thr Asp 
        435                 440                 445             


Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu 
    450                 455                 460                 


Glu Glu Glu Glu Glu Ala Thr Asp Ser Glu Glu Glu Glu Asp Leu Glu 
465                 470                 475                 480 


Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu Asp Glu Glu Glu 
                485                 490                 495     


Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro Met Ser Ser Leu 
            500                 505                 510         


Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys Gln Ile Ser Arg 
        515                 520                 525             


Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val Ser Pro Ser Leu 
    530                 535                 540                 


Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp Ala Glu Ser Asn 
545                 550                 555                 560 


Gly Glu Gln Pro Glu Glu Leu Thr Leu Glu Glu Glu Ser Pro Val Ser 
                565                 570                 575     


Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu Asp Thr Pro Ser 
            580                 585                 590         


Ser Val Glu Thr Asp Ile Ser Ser Ser Arg Lys Gln Ser Glu Glu Pro 
        595                 600                 605             


Phe Thr Thr Val Leu Glu Asn Gly Ala Gly Met Val Ser Ser Thr Ser 
    610                 615                 620                 


Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp Ser Gly Pro Pro 
625                 630                 635                 640 


Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly Ser Gly Pro Leu 
                645                 650                 655     


Gly Asn Ser Tyr Val Glu Arg Gln Arg Ser Val His Glu Lys Asn Gly 
            660                 665                 670         


Lys Lys Ile Cys Thr Leu Pro Ser Pro Pro Ser Pro Leu Ala Ser Leu 
        675                 680                 685             


Ala Pro Val Ala Asp Ser Ser Thr Arg Val Asp Ser Pro Ser His Gly 
    690                 695                 700                 


Leu Val Thr Ser Ser Leu Cys Ile Pro Ser Pro Ala Arg Leu Ser Gln 
705                 710                 715                 720 


Thr Pro His Ser Gln Pro Pro Arg Pro Gly Thr Cys Lys Thr Ser Val 
                725                 730                 735     


Ala Thr Gln Cys Asp Pro Glu Glu Ile Ile Val Leu Ser Asp Ser Asp 
            740                 745                 750         


<210>  2879
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAZ1__Homo_sapiens__NP_004072

<400>  2879

Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser 
                165                 170                 175     


Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser 
            180                 185                 190         


Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe 
        195                 200                 205             


Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys 
    210                 215                 220                 


Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg 
225                 230                 235                 240 


Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val 
                245                 250                 255     


Asp Val Gln Lys Ile Val Gly Ser Gln Ile His Phe His Gly Lys Lys 
            260                 265                 270         


Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His 
        275                 280                 285             


Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe 
    290                 295                 300                 


Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln 
305                 310                 315                 320 


Ile Thr Pro Asn Pro Val Thr Gln His Val Gln Ser Ala Ala Asn Pro 
                325                 330                 335     


Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser 
            340                 345                 350         


Ser Ala Ala Ala Ser Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val 
        355                 360                 365             


Pro Asn Thr Val Phe Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr 
    370                 375                 380                 


Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys 
385                 390                 395                 400 


Ile Ile Thr Asn Arg Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser 
                405                 410                 415     


Phe Val Asn Asp Val Asp Val Gln Lys Ile Val Gly Ser Gln Ile His 
            420                 425                 430         


Phe His Gly Lys Lys Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys 
        435                 440                 445             


Leu Cys Ala Arg His Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro 
    450                 455                 460                 


Pro Pro Pro Gln Phe Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr 
465                 470                 475                 480 


Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro Val Thr Gln His Val Gln 
                485                 490                 495     


Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly Gln Val Ile Thr Gly Cys 
            500                 505                 510         


Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr Pro Thr Tyr Pro Asp Ser 
        515                 520                 525             


Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
    530                 535                 540                 


Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe Gln Val Thr Ala Gly Tyr 
545                 550                 555                 560 


Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser 
                565                 570                 575     


Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln 
            580                 585                 590         


Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr Ala Gly Tyr 
        595                 600                 605             


Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser 
    610                 615                 620                 


Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln 
625                 630                 635                 640 


Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr 
                645                 650                 655     


Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser 
            660                 665                 670         


Pro Phe Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln 
        675                 680                 685             


Ala Phe Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr 
    690                 695                 700                 


Gln Phe His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly 
705                 710                 715                 720 


Glu Gln Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu 
                725                 730                 735     


Val Cys Leu Ile Gln Arg Arg Asp 
            740                 


<210>  2880
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAZ2__Homo_sapiens__NP_001005785

<400>  2880

Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
            260                 265                 270         


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr Thr Gly Tyr Gln Leu 
            340                 345                 350         


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
        355                 360                 365             


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
    370                 375                 380                 


Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr Thr Gly Tyr Gln Leu 
385                 390                 395                 400 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
                405                 410                 415     


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
            420                 425                 430         


Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        435                 440                 445             


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe 
    450                 455                 460                 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
465                 470                 475                 480 


Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe 
                485                 490                 495     


His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln 
            500                 505                 510         


Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys 
        515                 520                 525             


Leu Ile Gln Arg Arg Asp 
    530                 


<210>  2881
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAZ3__Homo_sapiens__NP_065097

<400>  2881

Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr Pro His Ser Pro Gly 
                165                 170                 175     


Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr Asn Tyr Gln Glu Tyr 
            180                 185                 190         


Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr Thr Gly Tyr Gln Leu 
        195                 200                 205             


Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr Pro Arg Ser Pro Phe 
    210                 215                 220                 


Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
225                 230                 235                 240 


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
                245                 250                 255     


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
            260                 265                 270         


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
        275                 280                 285             


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
    290                 295                 300                 


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
305                 310                 315                 320 


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
                325                 330                 335     


Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala Thr Gly Tyr Gln Phe 
            340                 345                 350         


Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Val 
        355                 360                 365             


Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe 
    370                 375                 380                 


Pro Ala Tyr Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe 
385                 390                 395                 400 


His Val Tyr Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln 
                405                 410                 415     


Arg Arg Asn Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys 
            420                 425                 430         


Leu Ile Gln Arg Arg Asp 
        435             


<210>  2882
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAZ4__Homo_sapiens__NP_001005375

<400>  2882

Met Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser Thr Ile Ser Arg Glu 
1               5                   10                  15      


Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser Gln Gly Trp Val Leu 
            20                  25                  30          


Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe Val Gly Gly Ile Asp 
        35                  40                  45              


Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys Phe Gly Arg Tyr Gly 
    50                  55                  60                  


Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg Thr Gly Val Ser Lys 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val Asp Val Gln Lys Ile 
                85                  90                  95      


Val Gly Ser Gln Ile His Phe His Gly Lys Lys Leu Lys Leu Gly Pro 
            100                 105                 110         


Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His Val Gln Pro Arg Pro 
        115                 120                 125             


Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe Gln Asn Val Trp Arg 
    130                 135                 140                 


Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln Ile Thr Pro Asn Pro 
145                 150                 155                 160 


Val Thr Gln His Val Gln Ser Ala Ala Asn Pro Glu Thr Pro Asn Ser 
                165                 170                 175     


Thr Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser Ser Ala Ala Ala Ser 
            180                 185                 190         


Gln Gly Trp Val Leu Pro Glu Gly Lys Ile Val Pro Asn Thr Val Phe 
        195                 200                 205             


Val Gly Gly Ile Asp Ala Arg Met Asp Glu Thr Glu Ile Gly Ser Cys 
    210                 215                 220                 


Phe Gly Arg Tyr Gly Ser Val Lys Glu Val Lys Ile Ile Thr Asn Arg 
225                 230                 235                 240 


Thr Gly Val Ser Lys Gly Tyr Gly Phe Val Ser Phe Val Asn Asp Val 
                245                 250                 255     


Asp Val Gln Lys Ile Val Gly Ser Gln Ile His Phe His Gly Lys Lys 
            260                 265                 270         


Leu Lys Leu Gly Pro Ala Ile Arg Lys Gln Lys Leu Cys Ala Arg His 
        275                 280                 285             


Val Gln Pro Arg Pro Leu Val Val Asn Pro Pro Pro Pro Pro Gln Phe 
    290                 295                 300                 


Gln Asn Val Trp Arg Asn Pro Asn Thr Glu Thr Tyr Leu Gln Pro Gln 
305                 310                 315                 320 


Ile Thr Pro Asn Pro Val Thr Gln His Val Gln Ala Tyr Ser Ala Tyr 
                325                 330                 335     


Pro His Ser Pro Gly Gln Val Ile Thr Gly Cys Gln Leu Leu Val Tyr 
            340                 345                 350         


Asn Tyr Gln Glu Tyr Pro Thr Tyr Pro Asp Ser Ala Phe Gln Val Thr 
        355                 360                 365             


Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr 
    370                 375                 380                 


Pro Arg Ser Pro Phe Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr 
385                 390                 395                 400 


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala 
                405                 410                 415     


Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln Pro Phe Pro Ala Tyr 
            420                 425                 430         


Pro Ser Ser Pro Phe Gln Val Thr Ala Gly Tyr Gln Leu Pro Val Tyr 
        435                 440                 445             


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Asn Ser Pro Phe Gln Val Ala 
    450                 455                 460                 


Thr Gly Tyr Gln Phe Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr 
465                 470                 475                 480 


Pro Asn Ser Pro Val Gln Val Thr Thr Gly Tyr Gln Leu Pro Val Tyr 
                485                 490                 495     


Asn Tyr Gln Ala Phe Pro Ala Tyr Pro Ser Ser Pro Phe Gln Val Thr 
            500                 505                 510         


Thr Gly Tyr Gln Leu Pro Val Tyr Asn Tyr Gln Ala Phe Pro Ala Tyr 
        515                 520                 525             


Pro Asn Ser Ala Val Gln Val Thr Thr Gly Tyr Gln Phe His Val Tyr 
    530                 535                 540                 


Asn Tyr Gln Met Pro Pro Gln Cys Pro Val Gly Glu Gln Arg Arg Asn 
545                 550                 555                 560 


Leu Trp Thr Glu Ala Tyr Lys Trp Trp Tyr Leu Val Cys Leu Ile Gln 
                565                 570                 575     


Arg Arg Asp 
            


<210>  2883
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAZAP1__Homo_sapiens__NP_061832

<400>  2883

Met Asn Asn Ser Gly Ala Asp Glu Ile Gly Lys Leu Phe Val Gly Gly 
1               5                   10                  15      


Leu Asp Trp Ser Thr Thr Gln Glu Thr Leu Arg Ser Tyr Phe Ser Gln 
            20                  25                  30          


Tyr Gly Glu Val Val Asp Cys Val Ile Met Lys Asp Lys Thr Thr Asn 
        35                  40                  45              


Gln Ser Arg Gly Phe Gly Phe Val Lys Phe Lys Asp Pro Asn Cys Val 
    50                  55                  60                  


Gly Thr Val Leu Ala Ser Arg Pro His Thr Leu Asp Gly Arg Asn Ile 
65                  70                  75                  80  


Asp Pro Lys Pro Cys Thr Pro Arg Gly Met Gln Pro Glu Arg Thr Arg 
                85                  90                  95      


Pro Lys Glu Gly Trp Gln Lys Gly Pro Arg Ser Asp Asn Ser Lys Ser 
            100                 105                 110         


Asn Lys Ile Phe Val Gly Gly Ile Pro His Asn Cys Gly Glu Thr Glu 
        115                 120                 125             


Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val Val Met 
    130                 135                 140                 


Ile Tyr Asp Ala Glu Lys Gln Arg Pro Arg Gly Phe Gly Phe Ile Thr 
145                 150                 155                 160 


Phe Glu Asp Glu Gln Ser Val Asp Gln Ala Val Asn Met His Phe His 
                165                 170                 175     


Asp Ile Met Gly Lys Lys Val Glu Val Lys Arg Ala Glu Pro Arg Asp 
            180                 185                 190         


Ser Lys Ser Gln Ala Pro Gly Gln Pro Gly Ala Ser Gln Trp Gly Ser 
        195                 200                 205             


Arg Val Val Pro Asn Ala Ala Asn Gly Trp Ala Gly Gln Pro Pro Pro 
    210                 215                 220                 


Thr Trp Gln Gln Gly Tyr Gly Pro Gln Gly Met Trp Val Pro Ala Gly 
225                 230                 235                 240 


Gln Ala Ile Gly Gly Tyr Gly Pro Pro Pro Ala Gly Arg Gly Ala Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Phe Thr Ser Tyr Ile Val Ser Thr Pro Pro Gly 
            260                 265                 270         


Gly Phe Pro Pro Pro Gln Gly Phe Pro Gln Gly Tyr Gly Ala Pro Pro 
        275                 280                 285             


Gln Phe Ser Phe Gly Tyr Gly Pro Pro Pro Pro Pro Pro Asp Gln Phe 
    290                 295                 300                 


Ala Pro Pro Gly Val Pro Pro Pro Pro Ala Thr Pro Gly Ala Ala Pro 
305                 310                 315                 320 


Leu Ala Phe Pro Pro Pro Pro Ser Gln Ala Ala Pro Asp Met Ser Lys 
                325                 330                 335     


Pro Pro Thr Ala Gln Pro Asp Phe Pro Tyr Gly Gln Tyr Ala Gly Tyr 
            340                 345                 350         


Gly Gln Asp Leu Ser Gly Phe Gly Gln Gly Phe Ser Asp Pro Ser Gln 
        355                 360                 365             


Gln Pro Pro Ser Tyr Gly Gly Pro Ser Val Pro Gly Ser Gly Gly Pro 
    370                 375                 380                 


Pro Ala Gly Gly Ser Gly Phe Gly Arg Gly Gln Asn His Asn Val Gln 
385                 390                 395                 400 


Gly Phe His Pro Tyr Arg Arg 
                405         


<210>  2884
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAZAP2__Homo_sapiens__NP_001129736

<400>  2884

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro Ile Tyr Pro Pro Gly Ser 
65                  70                  75                  80  


Thr Val Leu Val Glu Gly Gly Tyr Asp Ala Gly Ala Arg Phe Gly Ala 
                85                  90                  95      


Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro Pro Pro Gly Cys Pro Pro 
            100                 105                 110         


Asn Ala Ala Gln Leu Ala Val Met Gln Gly Ala Asn Val Leu Val Thr 
        115                 120                 125             


Gln Arg Lys Gly Asn Phe Phe Met Gly Gly Ser Asp Gly Gly Tyr Thr 
    130                 135                 140                 


Ile Trp 
145     


<210>  2885
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAZL__Homo_sapiens__NP_001177740

<400>  2885

Met Ala Ala Pro Ser Cys Gly Gly Asp Arg Lys Ala Arg Leu Thr Pro 
1               5                   10                  15      


Ser Leu Pro His Glu Ser Thr Ala Asn Pro Glu Thr Pro Asn Ser Thr 
            20                  25                  30          


Ile Ser Arg Glu Ala Ser Thr Gln Ser Ser Ser Ala Ala Thr Ser Gln 
        35                  40                  45              


Gly Tyr Ile Leu Pro Glu Gly Lys Ile Met Pro Asn Thr Val Phe Val 
    50                  55                  60                  


Gly Gly Ile Asp Val Arg Met Asp Glu Thr Glu Ile Arg Ser Phe Phe 
65                  70                  75                  80  


Ala Arg Tyr Gly Ser Val Lys Glu Val Lys Ile Ile Thr Asp Arg Thr 
                85                  90                  95      


Gly Val Ser Lys Gly Tyr Gly Phe Val Ser Phe Phe Asn Asp Val Asp 
            100                 105                 110         


Val Gln Lys Ile Val Glu Ser Gln Ile Asn Phe His Gly Lys Lys Leu 
        115                 120                 125             


Lys Leu Gly Pro Ala Ile Arg Lys Gln Asn Leu Cys Ala Tyr His Val 
    130                 135                 140                 


Gln Pro Arg Pro Leu Val Phe Asn His Pro Pro Pro Pro Gln Phe Gln 
145                 150                 155                 160 


Asn Val Trp Thr Asn Pro Asn Thr Glu Thr Tyr Met Gln Pro Thr Thr 
                165                 170                 175     


Thr Met Asn Pro Ile Thr Gln Tyr Val Gln Ala Tyr Pro Thr Tyr Pro 
            180                 185                 190         


Asn Ser Pro Val Gln Val Ile Thr Gly Tyr Gln Leu Pro Val Tyr Asn 
        195                 200                 205             


Tyr Gln Met Pro Pro Gln Trp Pro Val Gly Glu Gln Arg Ser Tyr Val 
    210                 215                 220                 


Val Pro Pro Ala Tyr Ser Ala Val Asn Tyr His Cys Asn Glu Val Asp 
225                 230                 235                 240 


Pro Gly Ala Glu Val Val Pro Asn Glu Cys Ser Val His Glu Ala Thr 
                245                 250                 255     


Pro Pro Ser Gly Asn Gly Pro Gln Lys Lys Ser Val Asp Arg Ser Ile 
            260                 265                 270         


Gln Thr Val Val Ser Cys Leu Phe Asn Pro Glu Asn Arg Leu Arg Asn 
        275                 280                 285             


Ser Val Val Thr Gln Asp Asp Tyr Phe Lys Asp Lys Arg Val His His 
    290                 295                 300                 


Phe Arg Arg Ser Arg Ala Met Leu Lys Ser Val 
305                 310                 315 


<210>  2886
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBF4__Homo_sapiens__NP_006707

<400>  2886

Met Asn Ser Gly Ala Met Arg Ile His Ser Lys Gly His Phe Gln Gly 
1               5                   10                  15      


Gly Ile Gln Val Lys Asn Glu Lys Asn Arg Pro Ser Leu Lys Ser Leu 
            20                  25                  30          


Lys Thr Asp Asn Arg Pro Glu Lys Ser Lys Cys Lys Pro Leu Trp Gly 
        35                  40                  45              


Lys Val Phe Tyr Leu Asp Leu Pro Ser Val Thr Ile Ser Glu Lys Leu 
    50                  55                  60                  


Gln Lys Asp Ile Lys Asp Leu Gly Gly Arg Val Glu Glu Phe Leu Ser 
65                  70                  75                  80  


Lys Asp Ile Ser Tyr Leu Ile Ser Asn Lys Lys Glu Ala Lys Phe Ala 
                85                  90                  95      


Gln Thr Leu Gly Arg Ile Ser Pro Val Pro Ser Pro Glu Ser Ala Tyr 
            100                 105                 110         


Thr Ala Glu Thr Thr Ser Pro His Pro Ser His Asp Gly Ser Ser Phe 
        115                 120                 125             


Lys Ser Pro Asp Thr Val Cys Leu Ser Arg Gly Lys Leu Leu Val Glu 
    130                 135                 140                 


Lys Ala Ile Lys Asp His Asp Phe Ile Pro Ser Asn Ser Ile Leu Ser 
145                 150                 155                 160 


Asn Ala Leu Ser Trp Gly Val Lys Ile Leu His Ile Asp Asp Ile Arg 
                165                 170                 175     


Tyr Tyr Ile Glu Gln Lys Lys Lys Glu Leu Tyr Leu Leu Lys Lys Ser 
            180                 185                 190         


Ser Thr Ser Val Arg Asp Gly Gly Lys Arg Val Gly Ser Gly Ala Gln 
        195                 200                 205             


Lys Thr Arg Thr Gly Arg Leu Lys Lys Pro Phe Val Lys Val Glu Asp 
    210                 215                 220                 


Met Ser Gln Leu Tyr Arg Pro Phe Tyr Leu Gln Leu Thr Asn Met Pro 
225                 230                 235                 240 


Phe Ile Asn Tyr Ser Ile Gln Lys Pro Cys Ser Pro Phe Asp Val Asp 
                245                 250                 255     


Lys Pro Ser Ser Met Gln Lys Gln Thr Gln Val Lys Leu Arg Ile Gln 
            260                 265                 270         


Thr Asp Gly Asp Lys Tyr Gly Gly Thr Ser Ile Gln Leu Gln Leu Lys 
        275                 280                 285             


Glu Lys Lys Lys Lys Gly Tyr Cys Glu Cys Cys Leu Gln Lys Tyr Glu 
    290                 295                 300                 


Asp Leu Glu Thr His Leu Leu Ser Glu Gln His Arg Asn Phe Ala Gln 
305                 310                 315                 320 


Ser Asn Gln Tyr Gln Val Val Asp Asp Ile Val Ser Lys Leu Val Phe 
                325                 330                 335     


Asp Phe Val Glu Tyr Glu Lys Asp Thr Pro Lys Lys Lys Arg Ile Lys 
            340                 345                 350         


Tyr Ser Val Gly Ser Leu Ser Pro Val Ser Ala Ser Val Leu Lys Lys 
        355                 360                 365             


Thr Glu Gln Lys Glu Lys Val Glu Leu Gln His Ile Ser Gln Lys Asp 
    370                 375                 380                 


Cys Gln Glu Asp Asp Thr Thr Val Lys Glu Gln Asn Phe Leu Tyr Lys 
385                 390                 395                 400 


Glu Thr Gln Glu Thr Glu Lys Lys Leu Leu Phe Ile Ser Glu Pro Ile 
                405                 410                 415     


Pro His Pro Ser Asn Glu Leu Arg Gly Leu Asn Glu Lys Met Ser Asn 
            420                 425                 430         


Lys Cys Ser Met Leu Ser Thr Ala Glu Asp Asp Ile Arg Gln Asn Phe 
        435                 440                 445             


Thr Gln Leu Pro Leu His Lys Asn Lys Gln Glu Cys Ile Leu Asp Ile 
    450                 455                 460                 


Ser Glu His Thr Leu Ser Glu Asn Asp Leu Glu Glu Leu Arg Val Asp 
465                 470                 475                 480 


His Tyr Lys Cys Asn Ile Gln Ala Ser Val His Val Ser Asp Phe Ser 
                485                 490                 495     


Thr Asp Asn Ser Gly Ser Gln Pro Lys Gln Lys Ser Asp Thr Val Leu 
            500                 505                 510         


Phe Pro Ala Lys Asp Leu Lys Glu Lys Asp Leu His Ser Ile Phe Thr 
        515                 520                 525             


His Asp Ser Gly Leu Ile Thr Ile Asn Ser Ser Gln Glu His Leu Thr 
    530                 535                 540                 


Val Gln Ala Lys Ala Pro Phe His Thr Pro Pro Glu Glu Pro Asn Glu 
545                 550                 555                 560 


Cys Asp Phe Lys Asn Met Asp Ser Leu Pro Ser Gly Lys Ile His Arg 
                565                 570                 575     


Lys Val Lys Ile Ile Leu Gly Arg Asn Arg Lys Glu Asn Leu Glu Pro 
            580                 585                 590         


Asn Ala Glu Phe Asp Lys Arg Thr Glu Phe Ile Thr Gln Glu Glu Asn 
        595                 600                 605             


Arg Ile Cys Ser Ser Pro Val Gln Ser Leu Leu Asp Leu Phe Gln Thr 
    610                 615                 620                 


Ser Glu Glu Lys Ser Glu Phe Leu Gly Phe Thr Ser Tyr Thr Glu Lys 
625                 630                 635                 640 


Ser Gly Ile Cys Asn Val Leu Asp Ile Trp Glu Glu Glu Asn Ser Asp 
                645                 650                 655     


Asn Leu Leu Thr Ala Phe Phe Ser Ser Pro Ser Thr Ser Thr Phe Thr 
            660                 665                 670         


Gly Phe 
        


<210>  2887
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBH__Homo_sapiens__NP_000778

<400>  2887

Met Pro Ala Leu Ser Arg Trp Ala Ser Leu Pro Gly Pro Ser Met Arg 
1               5                   10                  15      


Glu Ala Ala Phe Met Tyr Ser Thr Ala Val Ala Ile Phe Leu Val Ile 
            20                  25                  30          


Leu Val Ala Ala Leu Gln Gly Ser Ala Pro Arg Glu Ser Pro Leu Pro 
        35                  40                  45              


Tyr His Ile Pro Leu Asp Pro Glu Gly Ser Leu Glu Leu Ser Trp Asn 
    50                  55                  60                  


Val Ser Tyr Thr Gln Glu Ala Ile His Phe Gln Leu Leu Val Arg Arg 
65                  70                  75                  80  


Leu Lys Ala Gly Val Leu Phe Gly Met Ser Asp Arg Gly Glu Leu Glu 
                85                  90                  95      


Asn Ala Asp Leu Val Val Leu Trp Thr Asp Gly Asp Thr Ala Tyr Phe 
            100                 105                 110         


Ala Asp Ala Trp Ser Asp Gln Lys Gly Gln Ile His Leu Asp Pro Gln 
        115                 120                 125             


Gln Asp Tyr Gln Leu Leu Gln Val Gln Arg Thr Pro Glu Gly Leu Thr 
    130                 135                 140                 


Leu Leu Phe Lys Arg Pro Phe Gly Thr Cys Asp Pro Lys Asp Tyr Leu 
145                 150                 155                 160 


Ile Glu Asp Gly Thr Val His Leu Val Tyr Gly Ile Leu Glu Glu Pro 
                165                 170                 175     


Phe Arg Ser Leu Glu Ala Ile Asn Gly Ser Gly Leu Gln Met Gly Leu 
            180                 185                 190         


Gln Arg Val Gln Leu Leu Lys Pro Asn Ile Pro Glu Pro Glu Leu Pro 
        195                 200                 205             


Ser Asp Ala Cys Thr Met Glu Val Gln Ala Pro Asn Ile Gln Ile Pro 
    210                 215                 220                 


Ser Gln Glu Thr Thr Tyr Trp Cys Tyr Ile Lys Glu Leu Pro Lys Gly 
225                 230                 235                 240 


Phe Ser Arg His His Ile Ile Lys Tyr Glu Pro Ile Val Thr Lys Gly 
                245                 250                 255     


Asn Glu Ala Leu Val His His Met Glu Val Phe Gln Cys Ala Pro Glu 
            260                 265                 270         


Met Asp Ser Val Pro His Phe Ser Gly Pro Cys Asp Ser Lys Met Lys 
        275                 280                 285             


Pro Asp Arg Leu Asn Tyr Cys Arg His Val Leu Ala Ala Trp Ala Leu 
    290                 295                 300                 


Gly Ala Lys Ala Phe Tyr Tyr Pro Glu Glu Ala Gly Leu Ala Phe Gly 
305                 310                 315                 320 


Gly Pro Gly Ser Ser Arg Tyr Leu Arg Leu Glu Val His Tyr His Asn 
                325                 330                 335     


Pro Leu Val Ile Glu Gly Arg Asn Asp Ser Ser Gly Ile Arg Leu Tyr 
            340                 345                 350         


Tyr Thr Ala Lys Leu Arg Arg Phe Asn Ala Gly Ile Met Glu Leu Gly 
        355                 360                 365             


Leu Val Tyr Thr Pro Val Met Ala Ile Pro Pro Arg Glu Thr Ala Phe 
    370                 375                 380                 


Ile Leu Thr Gly Tyr Cys Thr Asp Lys Cys Thr Gln Leu Ala Leu Pro 
385                 390                 395                 400 


Pro Ser Gly Ile His Ile Phe Ala Ser Gln Leu His Thr His Leu Thr 
                405                 410                 415     


Gly Arg Lys Val Val Thr Val Leu Val Arg Asp Gly Arg Glu Trp Glu 
            420                 425                 430         


Ile Val Asn Gln Asp Asn His Tyr Ser Pro His Phe Gln Glu Ile Arg 
        435                 440                 445             


Met Leu Lys Lys Val Val Ser Val His Pro Gly Asp Val Leu Ile Thr 
    450                 455                 460                 


Ser Cys Thr Tyr Asn Thr Glu Asp Arg Glu Leu Ala Thr Val Gly Gly 
465                 470                 475                 480 


Phe Gly Ile Leu Glu Glu Met Cys Val Asn Tyr Val His Tyr Tyr Pro 
                485                 490                 495     


Gln Thr Gln Leu Glu Leu Cys Lys Ser Ala Val Asp Ala Gly Phe Leu 
            500                 505                 510         


Gln Lys Tyr Phe His Leu Ile Asn Arg Phe Asn Asn Glu Asp Val Cys 
        515                 520                 525             


Thr Cys Pro Gln Ala Ser Val Ser Gln Gln Phe Thr Ser Val Pro Trp 
    530                 535                 540                 


Asn Ser Phe Asn Arg Asp Val Leu Lys Ala Leu Tyr Ser Phe Ala Pro 
545                 550                 555                 560 


Ile Ser Met His Cys Asn Lys Ser Ser Ala Val Arg Phe Gln Gly Glu 
                565                 570                 575     


Trp Asn Leu Gln Pro Leu Pro Lys Val Ile Ser Thr Leu Glu Glu Pro 
            580                 585                 590         


Thr Pro Gln Cys Pro Thr Ser Gln Gly Arg Ser Pro Ala Gly Pro Thr 
        595                 600                 605             


Val Val Ser Ile Gly Gly Gly Lys Gly 
    610                 615         


<210>  2888
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBI__Homo_sapiens__NP_001073331

<400>  2888

Met Ser Gln Ala Glu Phe Glu Lys Ala Ala Glu Glu Val Arg His Leu 
1               5                   10                  15      


Lys Thr Lys Pro Ser Asp Glu Glu Met Leu Phe Ile Tyr Gly His Tyr 
            20                  25                  30          


Lys Gln Ala Thr Val Gly Asp Ile Asn Thr Glu Arg Pro Gly Met Leu 
        35                  40                  45              


Asp Phe Thr Gly Lys Ala Lys Trp Asp Ala Trp Asn Glu Leu Lys Gly 
    50                  55                  60                  


Thr Ser Lys Glu Asp Ala Met Lys Ala Tyr Ile Asn Lys Val Glu Glu 
65                  70                  75                  80  


Leu Lys Lys Lys Tyr Gly Ile 
                85          


<210>  2889
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBN1__Homo_sapiens__NP_004386

<400>  2889

Met Ala Gly Val Ser Phe Ser Gly His Arg Leu Glu Leu Leu Ala Ala 
1               5                   10                  15      


Tyr Glu Glu Val Ile Arg Glu Glu Ser Ala Ala Asp Trp Ala Leu Tyr 
            20                  25                  30          


Thr Tyr Glu Asp Gly Ser Asp Asp Leu Lys Leu Ala Ala Ser Gly Glu 
        35                  40                  45              


Gly Gly Leu Gln Glu Leu Ser Gly His Phe Glu Asn Gln Lys Val Met 
    50                  55                  60                  


Tyr Gly Phe Cys Ser Val Lys Asp Ser Gln Ala Ala Leu Pro Lys Tyr 
65                  70                  75                  80  


Val Leu Ile Asn Trp Val Gly Glu Asp Val Pro Asp Ala Arg Lys Cys 
                85                  90                  95      


Ala Cys Ala Ser His Val Ala Lys Val Ala Glu Phe Phe Gln Gly Val 
            100                 105                 110         


Asp Val Ile Val Asn Ala Ser Ser Val Glu Asp Ile Asp Ala Gly Ala 
        115                 120                 125             


Ile Gly Gln Arg Leu Ser Asn Gly Leu Ala Arg Leu Ser Ser Pro Val 
    130                 135                 140                 


Leu His Arg Leu Arg Leu Arg Glu Asp Glu Asn Ala Glu Pro Val Gly 
145                 150                 155                 160 


Thr Thr Tyr Gln Lys Thr Asp Ala Ala Val Glu Met Lys Arg Ile Asn 
                165                 170                 175     


Arg Glu Gln Phe Trp Glu Gln Ala Lys Lys Glu Glu Glu Leu Arg Lys 
            180                 185                 190         


Glu Glu Glu Arg Lys Lys Ala Leu Asp Glu Arg Leu Arg Phe Glu Gln 
        195                 200                 205             


Glu Arg Met Glu Gln Glu Arg Gln Glu Gln Glu Glu Arg Glu Arg Arg 
    210                 215                 220                 


Tyr Arg Glu Arg Glu Gln Gln Ile Glu Glu His Arg Arg Lys Gln Gln 
225                 230                 235                 240 


Thr Leu Glu Ala Glu Glu Ala Lys Arg Arg Leu Lys Glu Gln Ser Ile 
                245                 250                 255     


Phe Gly Asp His Arg Asp Glu Glu Glu Glu Thr His Met Lys Lys Ser 
            260                 265                 270         


Glu Ser Glu Val Glu Glu Ala Ala Ala Ile Ile Ala Gln Arg Pro Asp 
        275                 280                 285             


Asn Pro Arg Glu Phe Phe Lys Gln Gln Glu Arg Val Ala Ser Ala Ser 
    290                 295                 300                 


Ala Gly Ser Cys Asp Val Pro Ser Pro Phe Asn His Arg Pro Gly Ser 
305                 310                 315                 320 


His Leu Asp Ser His Arg Arg Met Ala Pro Thr Pro Ile Pro Thr Arg 
                325                 330                 335     


Ser Pro Ser Asp Ser Ser Thr Ala Ser Thr Pro Val Ala Glu Gln Ile 
            340                 345                 350         


Glu Arg Ala Leu Asp Glu Val Thr Ser Ser Gln Pro Pro Pro Leu Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Ala Gln Glu Thr Gln Glu Pro Ser Pro Ile Leu 
    370                 375                 380                 


Asp Ser Glu Glu Thr Arg Ala Ala Ala Pro Gln Ala Trp Ala Gly Pro 
385                 390                 395                 400 


Met Glu Glu Pro Pro Gln Ala Gln Ala Pro Pro Arg Gly Pro Gly Ser 
                405                 410                 415     


Pro Ala Glu Asp Leu Met Phe Met Glu Ser Ala Glu Gln Ala Val Leu 
            420                 425                 430         


Ala Ala Pro Val Glu Pro Ala Thr Ala Asp Ala Thr Glu Ile His Asp 
        435                 440                 445             


Ala Ala Asp Thr Ile Glu Thr Asp Thr Ala Thr Ala Asp Thr Thr Val 
    450                 455                 460                 


Ala Asn Asn Val Pro Pro Ala Ala Thr Ser Leu Ile Asp Leu Trp Pro 
465                 470                 475                 480 


Gly Asn Gly Glu Gly Ala Ser Thr Leu Gln Gly Glu Pro Arg Ala Pro 
                485                 490                 495     


Thr Pro Pro Ser Gly Thr Glu Val Thr Leu Ala Glu Val Pro Leu Leu 
            500                 505                 510         


Asp Glu Val Ala Pro Glu Pro Leu Leu Pro Ala Gly Glu Gly Cys Ala 
        515                 520                 525             


Thr Leu Leu Asn Phe Asp Glu Leu Pro Glu Pro Pro Ala Thr Phe Cys 
    530                 535                 540                 


Asp Pro Glu Glu Val Glu Gly Glu Pro Leu Ala Ala Pro Gln Thr Pro 
545                 550                 555                 560 


Thr Leu Pro Ser Ala Leu Glu Glu Leu Glu Gln Glu Gln Glu Pro Glu 
                565                 570                 575     


Pro His Leu Leu Thr Asn Gly Glu Thr Thr Gln Lys Glu Gly Thr Gln 
            580                 585                 590         


Ala Ser Glu Gly Tyr Phe Ser Gln Ser Gln Glu Glu Glu Phe Ala Gln 
        595                 600                 605             


Ser Glu Glu Leu Cys Ala Lys Ala Pro Pro Pro Val Phe Tyr Asn Lys 
    610                 615                 620                 


Pro Pro Glu Ile Asp Ile Thr Cys Trp Asp Ala Asp Pro Val Pro Glu 
625                 630                 635                 640 


Glu Glu Glu Gly Phe Glu Gly Gly Asp 
                645                 


<210>  2890
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBNL__Homo_sapiens__NP_001014436

<400>  2890

Met Ala Ala Asn Leu Ser Arg Asn Gly Pro Ala Leu Gln Glu Ala Tyr 
1               5                   10                  15      


Val Arg Val Val Thr Glu Lys Ser Pro Thr Asp Trp Ala Leu Phe Thr 
            20                  25                  30          


Tyr Glu Gly Asn Ser Asn Asp Ile Arg Val Ala Gly Thr Gly Glu Gly 
        35                  40                  45              


Gly Leu Glu Glu Met Val Glu Glu Leu Asn Ser Gly Lys Val Met Tyr 
    50                  55                  60                  


Ala Phe Cys Arg Val Lys Asp Pro Asn Ser Gly Leu Pro Lys Phe Val 
65                  70                  75                  80  


Leu Ile Asn Trp Thr Gly Glu Gly Val Asn Asp Val Arg Lys Gly Ala 
                85                  90                  95      


Cys Ala Ser His Val Ser Thr Met Ala Ser Phe Leu Lys Gly Ala His 
            100                 105                 110         


Val Thr Ile Asn Ala Arg Ala Glu Glu Asp Val Glu Pro Glu Cys Ile 
        115                 120                 125             


Met Glu Lys Val Ala Lys Ala Ser Gly Ala Asn Tyr Ser Phe His Lys 
    130                 135                 140                 


Glu Ser Gly Arg Phe Gln Asp Val Gly Pro Gln Ala Pro Val Gly Ser 
145                 150                 155                 160 


Val Tyr Gln Lys Thr Asn Ala Val Ser Glu Ile Lys Arg Val Gly Lys 
                165                 170                 175     


Asp Ser Phe Trp Ala Lys Ala Glu Lys Glu Glu Glu Asn Arg Arg Leu 
            180                 185                 190         


Glu Glu Lys Arg Arg Ala Glu Glu Ala Gln Arg Gln Leu Glu Gln Glu 
        195                 200                 205             


Arg Arg Glu Arg Glu Leu Arg Glu Ala Ala Arg Arg Glu Gln Arg Tyr 
    210                 215                 220                 


Gln Glu Gln Gly Gly Glu Ala Ser Pro Gln Arg Thr Trp Glu Gln Gln 
225                 230                 235                 240 


Gln Glu Val Val Ser Arg Asn Arg Asn Glu Gln Glu Ser Ala Val His 
                245                 250                 255     


Pro Arg Glu Ile Phe Lys Gln Lys Glu Arg Ala Met Ser Thr Thr Ser 
            260                 265                 270         


Ile Ser Ser Pro Gln Pro Gly Lys Leu Arg Ser Pro Phe Leu Gln Lys 
        275                 280                 285             


Gln Leu Thr Gln Pro Glu Thr His Phe Gly Arg Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ile Ser Arg Pro Arg Ala Asp Leu Pro Ala Glu Glu Pro Ala Pro Ser 
305                 310                 315                 320 


Thr Pro Pro Cys Leu Val Gln Ala Glu Glu Glu Ala Val Tyr Glu Glu 
                325                 330                 335     


Pro Pro Glu Gln Glu Thr Phe Tyr Glu Gln Pro Pro Leu Val Gln Gln 
            340                 345                 350         


Gln Gly Ala Gly Ser Glu His Ile Asp His His Ile Gln Gly Gln Gly 
        355                 360                 365             


Leu Ser Gly Gln Gly Leu Cys Ala Arg Ala Leu Tyr Asp Tyr Gln Ala 
    370                 375                 380                 


Ala Asp Asp Thr Glu Ile Ser Phe Asp Pro Glu Asn Leu Ile Thr Gly 
385                 390                 395                 400 


Ile Glu Val Ile Asp Glu Gly Trp Trp Arg Gly Tyr Gly Pro Asp Gly 
                405                 410                 415     


His Phe Gly Met Phe Pro Ala Asn Tyr Val Glu Leu Ile Glu 
            420                 425                 430 


<210>  2891
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBP__Homo_sapiens__NP_001343

<400>  2891

Met Ala Arg Pro Val Ser Asp Arg Thr Pro Ala Pro Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Gly Thr Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
            20                  25                  30          


Ser Leu Leu Gln Gly Thr Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
        35                  40                  45              


Leu Lys Glu Lys Glu Arg Lys Ala Ala Leu Pro Ala Ala Thr Thr Pro 
    50                  55                  60                  


Gly Pro Gly Leu Glu Thr Ala Gly Pro Ala Asp Ala Pro Ala Gly Ala 
65                  70                  75                  80  


Val Val Gly Gly Gly Ser Pro Arg Gly Arg Pro Gly Pro Val Pro Ala 
                85                  90                  95      


Pro Gly Leu Leu Ala Pro Leu Leu Trp Glu Arg Thr Leu Pro Phe Gly 
            100                 105                 110         


Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
        115                 120                 125             


Pro Pro Ser Pro Pro Pro Pro Gly Gly Pro Ser Pro Glu Pro Ser Pro 
    130                 135                 140                 


Ala Arg Thr Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Gly Ser Ala 
145                 150                 155                 160 


Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Ala Leu Gly 
                165                 170                 175     


Thr Ala Ser Gly His Arg Ala Gly Leu Thr Ser Arg Asp Thr Pro Ser 
            180                 185                 190         


Pro Val Asp Pro Asp Thr Val Glu Val Leu Met Thr Phe Glu Pro Asp 
        195                 200                 205             


Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Thr Phe Asp 
    210                 215                 220                 


Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
225                 230                 235                 240 


Met Lys Lys Ala Arg Lys Ile Gln Val Pro Glu Glu Gln Lys Asp Glu 
                245                 250                 255     


Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn Glu Ala Ala Lys Arg Ser 
            260                 265                 270         


Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ser Val Arg Ala Ala 
        275                 280                 285             


Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg Gln Glu Val Val Ala Val 
    290                 295                 300                 


Arg Gln Glu Leu Ser His Tyr Arg Ala Val Leu Ser Arg Tyr Gln Ala 
305                 310                 315                 320 


Gln His Gly Ala Leu 
                325 


<210>  2892
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBR1__Homo_sapiens__NP_057300

<400>  2892

Met Arg Val Ala Val Ala Gly Cys Cys His Gly Glu Leu Asp Lys Ile 
1               5                   10                  15      


Tyr Glu Thr Leu Ala Leu Ala Glu Arg Arg Gly Pro Gly Pro Val Asp 
            20                  25                  30          


Leu Leu Leu Cys Cys Gly Asp Phe Gln Ala Val Arg Asn Glu Ala Asp 
        35                  40                  45              


Leu Arg Cys Met Ala Val Pro Pro Lys Tyr Arg His Met Gln Thr Phe 
    50                  55                  60                  


Tyr Arg Tyr Tyr Ser Gly Glu Lys Lys Ala Pro Val Leu Thr Leu Phe 
65                  70                  75                  80  


Ile Gly Gly Asn His Glu Ala Ser Asn His Leu Gln Glu Leu Pro Tyr 
                85                  90                  95      


Gly Gly Trp Val Ala Pro Asn Ile Tyr Tyr Leu Gly Leu Ala Gly Val 
            100                 105                 110         


Val Lys Tyr Arg Gly Val Arg Ile Gly Gly Ile Ser Gly Ile Phe Lys 
        115                 120                 125             


Ser His Asp Tyr Arg Lys Gly His Phe Glu Cys Pro Pro Tyr Asn Ser 
    130                 135                 140                 


Ser Thr Ile Arg Ser Ile Tyr His Val Arg Asn Ile Glu Val Tyr Lys 
145                 150                 155                 160 


Leu Lys Gln Leu Lys Gln Pro Ile Asp Ile Phe Leu Ser His Asp Trp 
                165                 170                 175     


Pro Arg Ser Ile Tyr His Tyr Gly Asn Lys Lys Gln Leu Leu Lys Thr 
            180                 185                 190         


Lys Ser Phe Phe Arg Gln Glu Val Glu Asn Asn Thr Leu Gly Ser Pro 
        195                 200                 205             


Ala Ala Ser Glu Leu Leu Glu His Leu Lys Pro Thr Tyr Trp Phe Ser 
    210                 215                 220                 


Ala His Leu His Val Lys Phe Ala Ala Leu Met Gln His Gln Ala Lys 
225                 230                 235                 240 


Asp Lys Gly Gln Thr Ala Arg Ala Thr Lys Phe Leu Ala Leu Asp Lys 
                245                 250                 255     


Cys Leu Pro His Arg Asp Phe Leu Gln Ile Leu Glu Ile Glu His Asp 
            260                 265                 270         


Pro Ser Ala Pro Asp Tyr Leu Glu Tyr Asp Ile Glu Trp Leu Thr Ile 
        275                 280                 285             


Leu Arg Ala Thr Asp Asp Leu Ile Asn Val Thr Gly Arg Leu Trp Asn 
    290                 295                 300                 


Met Pro Glu Asn Asn Gly Leu His Ala Arg Trp Asp Tyr Ser Ala Thr 
305                 310                 315                 320 


Glu Glu Gly Met Lys Glu Val Leu Glu Lys Leu Asn His Asp Leu Lys 
                325                 330                 335     


Val Pro Cys Asn Phe Ser Val Thr Ala Ala Cys Tyr Asp Pro Ser Lys 
            340                 345                 350         


Pro Gln Thr Gln Met Gln Leu Ile His Arg Ile Asn Pro Gln Thr Thr 
        355                 360                 365             


Glu Phe Cys Ala Gln Leu Gly Ile Ile Asp Ile Asn Val Arg Leu Gln 
    370                 375                 380                 


Lys Ser Lys Glu Glu His His Val Cys Gly Glu Tyr Glu Glu Gln Asp 
385                 390                 395                 400 


Asp Val Glu Ser Asn Asp Ser Gly Glu Asp Gln Ser Glu Tyr Asn Thr 
                405                 410                 415     


Asp Thr Ser Ala Leu Ser Ser Ile Asn Pro Asp Glu Ile Met Leu Asp 
            420                 425                 430         


Glu Glu Glu Asp Glu Asp Ser Ile Val Ser Ala His Ser Gly Met Asn 
        435                 440                 445             


Thr Pro Ser Val Glu Pro Ser Asp Gln Ala Ser Glu Phe Ser Ala Ser 
    450                 455                 460                 


Phe Ser Asp Val Arg Ile Leu Pro Gly Ser Met Ile Val Ser Ser Asp 
465                 470                 475                 480 


Asp Thr Val Asp Ser Thr Ile Asp Arg Glu Gly Lys Pro Gly Gly Thr 
                485                 490                 495     


Val Glu Ser Gly Asn Gly Glu Asp Leu Thr Lys Val Pro Leu Lys Arg 
            500                 505                 510         


Leu Ser Asp Glu His Glu Pro Glu Gln Arg Lys Lys Ile Lys Arg Arg 
        515                 520                 525             


Asn Gln Ala Ile Tyr Ala Ala Val Asp Asp Asp Asp Asp Asp Ala Ala 
    530                 535                 540                 


<210>  2893
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBX1__Homo_sapiens__NP_001025036

<400>  2893

Met Met Phe Pro Gly Leu Leu Ala Pro Pro Ala Gly Tyr Pro Ser Leu 
1               5                   10                  15      


Leu Arg Pro Thr Pro Thr Leu Thr Leu Pro Gln Ser Leu Gln Ser Ala 
            20                  25                  30          


Phe Ser Gly His Ser Ser Phe Leu Val Glu Asp Leu Ile Arg Ile Ser 
        35                  40                  45              


Arg Pro Pro Ala Tyr Leu Pro Arg Ser Val Pro Thr Ala Ser Met Ser 
    50                  55                  60                  


Pro Pro Arg Gln Gly Ala Pro Thr Ala Leu Thr Asp Thr Gly Ala Ser 
65                  70                  75                  80  


Asp Leu Gly Ser Pro Gly Pro Gly Ser Arg Arg Gly Gly Ser Pro Pro 
                85                  90                  95      


Thr Ala Phe Ser Pro Ala Ser Glu Thr Thr Phe Leu Lys Phe Gly Val 
            100                 105                 110         


Asn Ala Ile Leu Ser Ser Gly Pro Arg Thr Glu Thr Ser Pro Ala Leu 
        115                 120                 125             


Leu Gln Ser Val Pro Pro Lys Thr Phe Ala Phe Pro Tyr Phe Glu Gly 
    130                 135                 140                 


Ser Phe Gln Pro Phe Ile Arg Ser Ser Tyr Phe Pro Ala Ser Ser Ser 
145                 150                 155                 160 


Val Val Pro Ile Pro Gly Thr Phe Ser Trp Pro Leu Ala Ala Arg Gly 
                165                 170                 175     


Lys Pro Arg Arg Gly Met Leu Arg Arg Ala Val Phe Ser Asp Val Gln 
            180                 185                 190         


Arg Lys Ala Leu Glu Lys Met Phe Gln Lys Gln Lys Tyr Ile Ser Lys 
        195                 200                 205             


Pro Asp Arg Lys Lys Leu Ala Ala Lys Leu Gly Leu Lys Asp Ser Gln 
    210                 215                 220                 


Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Arg Asn Ser Lys 
225                 230                 235                 240 


Glu Arg Glu Leu Leu Ser Ser Gly Gly Cys Arg Glu Gln Thr Leu Pro 
                245                 250                 255     


Thr Lys Leu Asn Pro His Pro Asp Leu Ser Asp Val Gly Gln Lys Gly 
            260                 265                 270         


Pro Gly Asn Glu Glu Glu Glu Glu Gly Pro Gly Ser Pro Ser His Arg 
        275                 280                 285             


Leu Ala Tyr His Ala Ser Ser Asp Pro Gln His Leu Arg Asp Pro Arg 
    290                 295                 300                 


Leu Pro Gly Pro Leu Pro Pro Ser Pro Ala His Ser Ser Ser Pro Gly 
305                 310                 315                 320 


Lys Pro Ser Asp Phe Ser Asp Ser Glu Glu Glu Glu Glu Gly Glu Glu 
                325                 330                 335     


Gln Glu Glu Ile Thr Val Ser 
            340             


<210>  2894
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF12__Homo_sapiens__NP_056212

<400>  2894

Met Ala Arg Lys Val Val Ser Arg Lys Arg Lys Ala Pro Ala Ser Pro 
1               5                   10                  15      


Gly Ala Gly Ser Asp Ala Gln Gly Pro Gln Phe Gly Trp Asp His Ser 
            20                  25                  30          


Leu His Lys Arg Lys Arg Leu Pro Pro Val Lys Arg Ser Leu Val Tyr 
        35                  40                  45              


Tyr Leu Lys Asn Arg Glu Val Arg Leu Gln Asn Glu Thr Ser Tyr Ser 
    50                  55                  60                  


Arg Val Leu His Gly Tyr Ala Ala Gln Gln Leu Pro Ser Leu Leu Lys 
65                  70                  75                  80  


Glu Arg Glu Phe His Leu Gly Thr Leu Asn Lys Val Phe Ala Ser Gln 
                85                  90                  95      


Trp Leu Asn His Arg Gln Val Val Cys Gly Thr Lys Cys Asn Thr Leu 
            100                 105                 110         


Phe Val Val Asp Val Gln Thr Ser Gln Ile Thr Lys Ile Pro Ile Leu 
        115                 120                 125             


Lys Asp Arg Glu Pro Gly Gly Val Thr Gln Gln Gly Cys Gly Ile His 
    130                 135                 140                 


Ala Ile Glu Leu Asn Pro Ser Arg Thr Leu Leu Ala Thr Gly Gly Asp 
145                 150                 155                 160 


Asn Pro Asn Ser Leu Ala Ile Tyr Arg Leu Pro Thr Leu Asp Pro Val 
                165                 170                 175     


Cys Val Gly Asp Asp Gly His Lys Asp Trp Ile Phe Ser Ile Ala Trp 
            180                 185                 190         


Ile Ser Asp Thr Met Ala Val Ser Gly Ser Arg Asp Gly Ser Met Gly 
        195                 200                 205             


Leu Trp Glu Val Thr Asp Asp Val Leu Thr Lys Ser Asp Ala Arg His 
    210                 215                 220                 


Asn Val Ser Arg Val Pro Val Tyr Ala His Ile Thr His Lys Ala Leu 
225                 230                 235                 240 


Lys Asp Ile Pro Lys Glu Asp Thr Asn Pro Asp Asn Cys Lys Val Arg 
                245                 250                 255     


Ala Leu Ala Phe Asn Asn Lys Asn Lys Glu Leu Gly Ala Val Ser Leu 
            260                 265                 270         


Asp Gly Tyr Phe His Leu Trp Lys Ala Glu Asn Thr Leu Ser Lys Leu 
        275                 280                 285             


Leu Ser Thr Lys Leu Pro Tyr Cys Arg Glu Asn Val Cys Leu Ala Tyr 
    290                 295                 300                 


Gly Ser Glu Trp Ser Val Tyr Ala Val Gly Ser Gln Ala His Val Ser 
305                 310                 315                 320 


Phe Leu Asp Pro Arg Gln Pro Ser Tyr Asn Val Lys Ser Val Cys Ser 
                325                 330                 335     


Arg Glu Arg Gly Ser Gly Ile Arg Ser Val Ser Phe Tyr Glu His Ile 
            340                 345                 350         


Ile Thr Val Gly Thr Gly Gln Gly Ser Leu Leu Phe Tyr Asp Ile Arg 
        355                 360                 365             


Ala Gln Arg Phe Leu Glu Glu Arg Leu Ser Ala Cys Tyr Gly Ser Lys 
    370                 375                 380                 


Pro Arg Leu Ala Gly Glu Asn Leu Lys Leu Thr Thr Gly Lys Gly Trp 
385                 390                 395                 400 


Leu Asn His Asp Glu Thr Trp Arg Asn Tyr Phe Ser Asp Ile Asp Phe 
                405                 410                 415     


Phe Pro Asn Ala Val Tyr Thr His Cys Tyr Asp Ser Ser Gly Thr Lys 
            420                 425                 430         


Leu Phe Val Ala Gly Gly Pro Leu Pro Ser Gly Leu His Gly Asn Tyr 
        435                 440                 445             


Ala Gly Leu Trp Ser 
    450             


<210>  2895
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF13__Homo_sapiens__NP_056235

<400>  2895

Met Gln Trp Pro Pro Pro Trp Arg Arg Ser Pro Leu Val Ser Ala Thr 
1               5                   10                  15      


Pro Pro Pro Gly Pro Thr Arg Gly Leu Leu Cys Pro Arg Arg Val Ser 
            20                  25                  30          


Glu Ala Gly Asp Ser Ser Thr Glu Gly Ala Arg Thr Gly His Arg His 
        35                  40                  45              


Tyr Val Thr Pro Ala Glu Ser Ala Met Glu Gly Arg Ser Gln Pro Leu 
    50                  55                  60                  


Pro Ser Leu Arg Pro Ala Ser Pro Thr Asn Ala Pro Ala His Gly Arg 
65                  70                  75                  80  


Gly Ser Asp Cys Thr Ala Lys Glu Pro Pro Leu Ala Asn Val Cys Arg 
                85                  90                  95      


Gln Asn Tyr Gly Ala Ala Gln Asp Pro Val Glu Pro Ala Gly Arg Arg 
            100                 105                 110         


Ser Ala Ser His Val Thr Gly Ser Ser Leu Gly Lys Ala Glu Val Ala 
        115                 120                 125             


Cys Gly Arg Arg Trp Arg Trp Ala Glu Leu Leu Ala Asp Thr Ser Trp 
    130                 135                 140                 


Ser Pro Ala Gly Arg Ala Thr Glu Met Lys Val Lys Met Leu Ser Arg 
145                 150                 155                 160 


Asn Pro Asp Asn Tyr Val Arg Glu Thr Lys Leu Asp Leu Gln Arg Val 
                165                 170                 175     


Pro Arg Asn Tyr Asp Pro Ala Leu His Pro Phe Glu Val Pro Arg Glu 
            180                 185                 190         


Tyr Ile Arg Ala Leu Asn Ala Thr Lys Leu Glu Arg Val Phe Ala Lys 
        195                 200                 205             


Pro Phe Leu Ala Ser Leu Asp Gly His Arg Asp Gly Val Asn Cys Leu 
    210                 215                 220                 


Ala Lys His Pro Glu Lys Leu Ala Thr Val Leu Ser Gly Ala Cys Asp 
225                 230                 235                 240 


Gly Glu Val Arg Ile Trp Asn Leu Thr Gln Arg Asn Cys Ile Arg Thr 
                245                 250                 255     


Ile Gln Ala His Glu Gly Phe Val Arg Gly Ile Cys Thr Arg Phe Cys 
            260                 265                 270         


Gly Thr Ser Phe Phe Thr Val Gly Asp Asp Lys Thr Val Lys Gln Trp 
        275                 280                 285             


Lys Met Asp Gly Pro Gly Tyr Gly Asp Glu Glu Glu Pro Leu His Thr 
    290                 295                 300                 


Ile Leu Gly Lys Thr Val Tyr Thr Gly Ile Asp His His Trp Lys Glu 
305                 310                 315                 320 


Ala Val Phe Ala Thr Cys Gly Gln Gln Val Asp Ile Trp Asp Glu Gln 
                325                 330                 335     


Arg Thr Asn Pro Ile Cys Ser Met Thr Trp Gly Phe Asp Ser Ile Ser 
            340                 345                 350         


Ser Val Lys Phe Asn Pro Ile Glu Thr Phe Leu Leu Gly Ser Cys Ala 
        355                 360                 365             


Ser Asp Arg Asn Ile Val Leu Tyr Asp Met Arg Gln Ala Thr Pro Leu 
    370                 375                 380                 


Lys Lys Val Ile Leu Asp Met Arg Thr Asn Thr Ile Cys Trp Asn Pro 
385                 390                 395                 400 


Met Glu Ala Phe Ile Phe Thr Ala Ala Asn Glu Asp Tyr Asn Leu Tyr 
                405                 410                 415     


Thr Phe Asp Met Arg Ala Leu Asp Thr Pro Val Met Val His Met Asp 
            420                 425                 430         


His Val Ser Ala Val Leu Asp Val Asp Tyr Ser Pro Thr Gly Lys Glu 
        435                 440                 445             


Phe Val Ser Ala Ser Phe Asp Lys Ser Ile Arg Ile Phe Pro Val Asp 
    450                 455                 460                 


Lys Ser Arg Ser Arg Glu Val Tyr His Thr Lys Arg Met Gln His Val 
465                 470                 475                 480 


Ile Cys Val Lys Trp Thr Ser Asp Ser Lys Tyr Ile Met Cys Gly Ser 
                485                 490                 495     


Asp Glu Met Asn Ile Arg Leu Trp Lys Ala Asn Ala Ser Glu Lys Leu 
            500                 505                 510         


Gly Val Leu Thr Ser Arg Glu Lys Ala Ala Lys Asp Tyr Asn Gln Lys 
        515                 520                 525             


Leu Lys Glu Lys Phe Gln His Tyr Pro His Ile Lys Arg Ile Ala Arg 
    530                 535                 540                 


His Arg His Leu Pro Lys Ser Ile Tyr Ser Gln Ile Gln Glu Gln Arg 
545                 550                 555                 560 


Ile Met Lys Glu Ala Arg Arg Arg Lys Glu Val Asn Arg Ile Lys His 
                565                 570                 575     


Ser Lys Pro Gly Ser Val Pro Leu Val Ser Glu Lys Lys Lys His Val 
            580                 585                 590         


Val Ala Val Val Lys 
        595         


<210>  2896
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF17__Homo_sapiens__NP_001158293

<400>  2896

Met Gly Pro Thr Arg Lys Pro Asn Val Cys Ser Arg Leu Ser Arg Arg 
1               5                   10                  15      


Ala Leu Gly Cys Phe Ser Arg Asp Ala Gly Val Val Gln Arg Thr Asn 
            20                  25                  30          


Leu Gly Ile Leu Arg Ala Leu Val Cys Gln Glu Ser Thr Lys Phe Lys 
        35                  40                  45              


Asn Val Trp Thr Thr His Ser Arg Ser Pro Ile Ala Tyr Glu Arg Gly 
    50                  55                  60                  


Arg Ile Tyr Phe Asp Asn Tyr Arg Arg Cys Val Ser Ser Val Ala Ser 
65                  70                  75                  80  


Glu Pro Arg Lys Leu Tyr Glu Met Pro Lys Cys Ser Lys Ser Glu Lys 
                85                  90                  95      


Ile Glu Asp Ala Leu Leu Trp Glu Cys Pro Val Gly Asp Ile Leu Pro 
            100                 105                 110         


Asn Ser Ser Asp Tyr Lys Ser Ser Leu Ile Ala Leu Thr Ala His Asn 
        115                 120                 125             


Trp Leu Leu Arg Ile Ser Ala Thr Thr Gly Lys Ile Leu Glu Lys Ile 
    130                 135                 140                 


Tyr Leu Ala Pro Tyr Cys Lys Phe Arg Tyr Leu Ser Trp Asp Thr Pro 
145                 150                 155                 160 


Gln Glu Val Ile Ala Val Lys Ser Ala Gln Asn Arg Gly Ser Ala Val 
                165                 170                 175     


Ala Arg Gln Ala Gly Ile Gln Gln His Val Leu Leu Tyr Leu Ala Val 
            180                 185                 190         


Phe Arg Val Leu Pro Phe Ser Leu Val Gly Ile Leu Glu Ile Asn Lys 
        195                 200                 205             


Lys Ile Phe Gly Asn Val Thr Asp Ala Thr Leu Ser His Gly Ile Leu 
    210                 215                 220                 


Ile Val Met Tyr Ser Ser Gly Leu Val Arg Leu Tyr Ser Phe Gln Thr 
225                 230                 235                 240 


Ile Ala Glu Gln Phe Met Gln Gln Lys Leu Asp Leu Gly Cys Ala Cys 
                245                 250                 255     


Arg Trp Gly Gly Thr Thr Gly Thr Val Gly Glu Ala Pro Phe Gly Ile 
            260                 265                 270         


Pro Cys Asn Ile Lys Ile Thr Asp Met Pro Pro Leu Leu Phe Glu Val 
        275                 280                 285             


Ser Ser Leu Glu Asn Ala Phe Gln Ile Gly Gly His Pro Trp His Tyr 
    290                 295                 300                 


Ile Val Thr Pro Asn Lys Lys Lys Gln Lys Gly Val Phe His Ile Cys 
305                 310                 315                 320 


Ala Leu Lys Asp Asn Ser Leu Asn Glu Asn Val Leu Thr Val Thr Ala 
                325                 330                 335     


Ser Gly Arg Val Val Lys Lys Ser Phe Asn Leu Leu Asp Asp Asp Pro 
            340                 345                 350         


Glu Gln Glu Thr Phe Lys Ile Val Asp Tyr Glu Asp Glu Leu Asp Leu 
        355                 360                 365             


Leu Ser Val Val Ala Val Thr Gln Ile Asp Ala Glu Gly Lys Ala His 
    370                 375                 380                 


Leu Asp Phe His Cys Asn Glu Tyr Gly Thr Leu Leu Lys Ser Ile Pro 
385                 390                 395                 400 


Leu Val Glu Ser Trp Asp Val Thr Tyr Ser His Glu Val Tyr Phe Asp 
                405                 410                 415     


Arg Asp Leu Val Leu His Ile Glu Gln Lys Pro Asn Arg Val Phe Ser 
            420                 425                 430         


Cys Tyr Val Tyr Gln Met Ile Cys Asp Thr Gly Glu Glu Glu Glu Thr 
        435                 440                 445             


Ile Asn Arg Ser Cys 
    450             


<210>  2897
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF4__Homo_sapiens__NP_001156980

<400>  2897

Met Asn Lys Ser Arg Trp Gln Ser Arg Arg Arg His Gly Arg Arg Ser 
1               5                   10                  15      


His Gln Gln Asn Pro Trp Phe Arg Leu Arg Asp Ser Glu Asp Arg Ser 
            20                  25                  30          


Asp Ser Arg Ala Ala Gln Pro Ala His Asp Ser Gly His Gly Asp Asp 
        35                  40                  45              


Glu Ser Pro Ser Thr Ser Ser Gly Thr Ala Gly Thr Ser Ser Val Pro 
    50                  55                  60                  


Glu Leu Pro Gly Phe Tyr Phe Asp Pro Glu Lys Lys Arg Tyr Phe Arg 
65                  70                  75                  80  


Leu Leu Pro Gly His Asn Asn Cys Asn Pro Leu Thr Lys Glu Ser Ile 
                85                  90                  95      


Arg Gln Lys Glu Met Glu Ser Lys Arg Leu Arg Leu Leu Gln Glu Glu 
            100                 105                 110         


Asp Arg Arg Lys Lys Ile Ala Arg Met Gly Phe Asn Ala Ser Ser Met 
        115                 120                 125             


Leu Arg Lys Ser Gln Leu Gly Phe Leu Asn Val Thr Asn Tyr Cys His 
    130                 135                 140                 


Leu Ala His Glu Leu Arg Leu Ser Cys Met Glu Arg Lys Lys Val Gln 
145                 150                 155                 160 


Ile Arg Ser Met Asp Pro Ser Ala Leu Ala Ser Asp Arg Phe Asn Leu 
                165                 170                 175     


Ile Leu Ala Asp Thr Asn Ser Asp Arg Leu Phe Thr Val Asn Asp Val 
            180                 185                 190         


Lys Val Gly Gly Ser Lys Tyr Gly Ile Ile Asn Leu Gln Ser Leu Lys 
        195                 200                 205             


Thr Pro Thr Leu Lys Val Phe Met His Glu Asn Leu Tyr Phe Thr Asn 
    210                 215                 220                 


Arg Lys Val Asn Ser Val Cys Trp Ala Ser Leu Asn His Leu Asp Ser 
225                 230                 235                 240 


His Ile Leu Leu Cys Leu Met Gly Leu Ala Glu Thr Pro Gly Cys Ala 
                245                 250                 255     


Thr Leu Leu Pro Ala Ser Leu Phe Val Asn Ser His Pro Ala Gly Ile 
            260                 265                 270         


Asp Arg Pro Gly Met Leu Cys Ser Phe Arg Ile Pro Gly Ala Trp Ser 
        275                 280                 285             


Cys Ala Trp Ser Leu Asn Ile Gln Ala Asn Asn Cys Phe Ser Thr Gly 
    290                 295                 300                 


Leu Ser Arg Arg Val Leu Leu Thr Asn Val Val Thr Gly His Arg Gln 
305                 310                 315                 320 


Ser Phe Gly Thr Asn Ser Asp Val Leu Ala Pro Leu Leu Phe Asn Gly 
                325                 330                 335     


Cys Arg Ser Gly Glu Ile Phe Ala Ile Asp Leu Arg Cys Gly Asn Gln 
            340                 345                 350         


Gly Lys Gly Trp Lys Ala Thr Arg Leu Phe His Asp Ser Ala Val Thr 
        355                 360                 365             


Ser Val Arg Ile Leu Gln Asp Glu Gln Tyr Leu Met Ala Ser Asp Met 
    370                 375                 380                 


Ala Gly Lys Ile Lys Leu Trp Asp Leu Arg Thr Thr Lys Cys Val Arg 
385                 390                 395                 400 


Gln Tyr Glu Gly His Val Asn Glu Tyr Ala Tyr Leu Pro Leu His Val 
                405                 410                 415     


His Glu Glu Glu Gly Ile Leu Val Ala Val Gly Gln Asp Cys Tyr Thr 
            420                 425                 430         


Arg Ile Trp Ser Leu His Asp Ala Arg Leu Leu Arg Thr Ile Pro Ser 
        435                 440                 445             


Pro Tyr Pro Ala Ser Lys Ala Asp Ile Pro Ser Val Ala Phe Ser Ser 
    450                 455                 460                 


Arg Leu Gly Gly Ser Arg Gly Ala Pro Gly Leu Leu Met Ala Val Gly 
465                 470                 475                 480 


Gln Asp Leu Tyr Cys Tyr Ser Tyr Ser 
                485                 


<210>  2898
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF5__Homo_sapiens__NP_001271136

<400>  2898

Met Glu Gln Ala Ile His Ser Arg Val Lys Pro Ile Gln Leu Lys Gly 
1               5                   10                  15      


Glu His His Ser Asn Ile Phe Cys Leu Ala Phe Asn Ser Gly Asn Thr 
            20                  25                  30          


Lys Val Phe Ser Gly Gly Asn Asp Glu Gln Val Ile Leu His Asp Val 
        35                  40                  45              


Glu Ser Ser Glu Thr Leu Asp Val Phe Ala His Glu Asp Ala Val Tyr 
    50                  55                  60                  


Gly Leu Ser Val Ser Pro Val Asn Asp Asn Ile Phe Ala Ser Ser Ser 
65                  70                  75                  80  


Asp Asp Gly Arg Val Leu Ile Trp Asp Ile Arg Glu Ser Pro His Gly 
                85                  90                  95      


Glu Pro Phe Cys Leu Ala Asn Tyr Pro Ser Ala Phe His Ser Val Met 
            100                 105                 110         


Phe Asn Pro Val Glu Pro Arg Leu Leu Ala Thr Ala Asn Ser Lys Glu 
        115                 120                 125             


Gly Val Gly Leu Trp Asp Ile Arg Lys Pro Gln Ser Ser Leu Leu Arg 
    130                 135                 140                 


Tyr Gly Gly Asn Leu Ser Leu Gln Ser Ala Met Ser Val Arg Phe Asn 
145                 150                 155                 160 


Ser Asn Gly Thr Gln Leu Leu Ala Leu Arg Arg Arg Leu Pro Pro Val 
                165                 170                 175     


Leu Tyr Asp Ile His Ser Arg Leu Pro Val Phe Gln Phe Asp Asn Gln 
            180                 185                 190         


Gly Tyr Phe Asn Ser Cys Thr Met Lys Ser Cys Cys Phe Ala Gly Asp 
        195                 200                 205             


Arg Asp Gln Tyr Ile Leu Ser Gly Ser Asp Asp Phe Asn Leu Tyr Met 
    210                 215                 220                 


Trp Arg Ile Pro Ala Asp Pro Glu Ala Gly Gly Ile Gly Arg Val Val 
225                 230                 235                 240 


Asn Gly Ala Phe Met Val Leu Lys Gly His Arg Ser Ile Val Asn Gln 
                245                 250                 255     


Val Arg Phe Asn Pro His Thr Tyr Met Ile Cys Ser Ser Gly Val Glu 
            260                 265                 270         


Lys Ile Ile Lys Ile Trp Ser Pro Tyr Lys Gln Pro Gly Cys Thr Gly 
        275                 280                 285             


Asp Leu Asp Gly Arg Ile Glu Asp Asp Ser Arg Cys Leu Tyr Thr His 
    290                 295                 300                 


Glu Glu Tyr Ile Ser Leu Val Leu Asn Ser Gly Ser Gly Leu Ser His 
305                 310                 315                 320 


Asp Tyr Ala Asn Gln Ser Val Gln Glu Asp Pro Arg Met Met Ala Phe 
                325                 330                 335     


Phe Asp Ser Leu Val Arg Arg Glu Ile Glu Gly Trp Ser Ser Asp Ser 
            340                 345                 350         


Asp Ser Asp Leu Ser Glu Ser Thr Ile Leu Gln Leu His Ala Gly Val 
        355                 360                 365             


Ser Glu Arg Ser Gly Tyr Thr Asp Ser Glu Ser Ser Ala Ser Leu Pro 
    370                 375                 380                 


Arg Ser Pro Pro Pro Thr Val Asp Glu Ser Ala Asp Asn Ala Phe His 
385                 390                 395                 400 


Leu Gly Pro Leu Arg Val Thr Thr Thr Asn Thr Val Ala Ser Thr Pro 
                405                 410                 415     


Pro Thr Pro Thr Cys Glu Asp Ala Ala Ser Arg Gln Gln Arg Leu Ser 
            420                 425                 430         


Ala Leu Arg Arg Tyr Gln Asp Lys Arg Leu Leu Ala Leu Ser Asn Glu 
        435                 440                 445             


Ser Asp Ser Glu Glu Asn Val Cys Glu Val Glu Leu Asp Thr Asp Leu 
    450                 455                 460                 


Phe Pro Arg Pro Arg Ser Pro Ser Pro Glu Asp Glu Ser Ser Ser Ser 
465                 470                 475                 480 


Ser Ser Ser Ser Ser Ser Glu Asp Glu Glu Glu Leu Asn Glu Arg Arg 
                485                 490                 495     


Ala Ser Thr Trp Gln Arg Asn Ala Met Arg Arg Arg Gln Lys Thr Thr 
            500                 505                 510         


Arg Glu Asp Lys Pro Ser Ala Pro Ile Lys Pro Thr Asn Thr Tyr Ile 
        515                 520                 525             


Gly Glu Asp Asn Tyr Asp Tyr Pro Gln Ile Lys Val Asp Asp Leu Ser 
    530                 535                 540                 


Ser Ser Pro Thr Ser Ser Pro Glu Arg Ser Thr Ser Thr Leu Glu Ile 
545                 550                 555                 560 


Gln Pro Ser Arg Ala Ser Pro Thr Ser Asp Ile Glu Ser Val Glu Arg 
                565                 570                 575     


Lys Ile Tyr Lys Ala Tyr Lys Trp Leu Arg Tyr Ser Tyr Ile Ser Tyr 
            580                 585                 590         


Ser Asn Asn Lys Asp Gly Glu Thr Ser Leu Val Thr Gly Glu Ala Asp 
        595                 600                 605             


Glu Gly Arg Ala Gly Thr Ser His Lys Asp Asn Pro Ala Pro Ser Ser 
    610                 615                 620                 


Ser Lys Glu Ala Cys Leu Asn Ile Ala Met Ala Gln Arg Asn Gln Asp 
625                 630                 635                 640 


Leu Pro Pro Glu Gly Cys Ser Lys Asp Thr Phe Lys Glu Glu Thr Pro 
                645                 650                 655     


Arg Thr Pro Ser Asn Gly Pro Gly His Glu His Ser Ser His Ala Trp 
            660                 665                 670         


Ala Glu Val Pro Glu Gly Thr Ser Gln Asp Thr Gly Asn Ser Gly Ser 
        675                 680                 685             


Val Glu His Pro Phe Glu Thr Lys Lys Leu Asn Gly Lys Ala Leu Ser 
    690                 695                 700                 


Ser Arg Ala Glu Glu Pro Pro Ser Pro Pro Val Pro Lys Ala Ser Gly 
705                 710                 715                 720 


Ser Thr Leu Asn Ser Gly Ser Gly Asn Cys Pro Arg Thr Gln Ser Asp 
                725                 730                 735     


Asp Ser Glu Glu Arg Ser Leu Glu Thr Ile Cys Ala Asn His Asn Asn 
            740                 745                 750         


Gly Arg Leu His Pro Arg Pro Pro His Pro His Asn Asn Gly Gln Asn 
        755                 760                 765             


Leu Gly Glu Leu Glu Val Val Ala Tyr Ser Ser Pro Gly His Ser Asp 
    770                 775                 780                 


Thr Asp Arg Asp Asn Ser Ser Leu Thr Gly Thr Leu Leu His Lys Asp 
785                 790                 795                 800 


Cys Cys Gly Ser Glu Met Ala Cys Glu Thr Pro Asn Ala Gly Thr Arg 
                805                 810                 815     


Glu Asp Pro Thr Asp Thr Pro Ala Thr Asp Ser Ser Arg Ala Val His 
            820                 825                 830         


Gly His Ser Gly Leu Lys Arg Gln Arg Ile Glu Leu Glu Asp Thr Asp 
        835                 840                 845             


Ser Glu Asn Ser Ser Ser Glu Lys Lys Leu Lys Thr 
    850                 855                 860 


<210>  2899
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF6__Homo_sapiens__NP_001017977

<400>  2899

Met Ser Arg Gly Gly Ser Tyr Pro His Leu Leu Trp Asp Val Arg Lys 
1               5                   10                  15      


Arg Ser Leu Gly Leu Glu Asp Pro Ser Arg Leu Arg Ser Arg Tyr Leu 
            20                  25                  30          


Gly Arg Arg Glu Phe Ile Gln Arg Leu Lys Leu Glu Ala Thr Leu Asn 
        35                  40                  45              


Val His Asp Gly Cys Val Asn Thr Ile Cys Trp Asn Asp Thr Gly Glu 
    50                  55                  60                  


Tyr Ile Leu Ser Gly Ser Asp Asp Thr Lys Leu Val Ile Ser Asn Pro 
65                  70                  75                  80  


Tyr Ser Arg Lys Val Leu Thr Thr Ile Arg Ser Gly His Arg Ala Asn 
                85                  90                  95      


Ile Phe Ser Ala Lys Phe Leu Pro Cys Thr Asn Asp Lys Gln Ile Val 
            100                 105                 110         


Ser Cys Ser Gly Asp Gly Val Ile Phe Tyr Thr Asn Val Glu Gln Asp 
        115                 120                 125             


Ala Glu Thr Asn Arg Gln Cys Gln Phe Thr Cys His Tyr Gly Thr Thr 
    130                 135                 140                 


Tyr Glu Ile Met Thr Val Pro Asn Asp Pro Tyr Thr Phe Leu Ser Cys 
145                 150                 155                 160 


Gly Glu Asp Gly Thr Val Arg Trp Phe Asp Thr Arg Ile Lys Thr Ser 
                165                 170                 175     


Cys Thr Lys Glu Asp Cys Lys Asp Asp Ile Leu Ile Asn Cys Arg Arg 
            180                 185                 190         


Ala Ala Thr Ser Val Ala Ile Cys Pro Pro Ile Pro Tyr Tyr Leu Ala 
        195                 200                 205             


Val Gly Cys Ser Asp Ser Ser Val Arg Ile Tyr Asp Arg Arg Met Leu 
    210                 215                 220                 


Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr Gly Met 
225                 230                 235                 240 


Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser Cys Arg Val 
                245                 250                 255     


Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val Ser Tyr 
            260                 265                 270         


Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr Ala Arg 
        275                 280                 285             


Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu Arg Gln 
    290                 295                 300                 


Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp Thr Gly 
305                 310                 315                 320 


Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu Gln Ser 
                325                 330                 335     


Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu Ser Arg Trp 
            340                 345                 350         


Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly Arg Gly Arg 
        355                 360                 365             


Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr Leu Pro 
    370                 375                 380                 


Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr Ala Met Glu 
385                 390                 395                 400 


Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr 
                405                 410                 415     


Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu Ser Pro His 
            420                 425                 430         


Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln Ser Val 
        435                 440                 445             


Glu Ala Ser Gly His His Thr His His Gln Ser Asp Asn Asn Asn Glu 
    450                 455                 460                 


Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu Pro Val Leu Ser Leu His 
465                 470                 475                 480 


Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr Ile Lys Leu Asn Phe Thr 
                485                 490                 495     


Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser Arg Gly Ile Gly Ser His 
            500                 505                 510         


Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe Val Pro Gln Ser Ser Val 
        515                 520                 525             


Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys Ala Pro Glu Glu Ser Ser 
    530                 535                 540                 


Glu Asp Val Thr Lys Tyr Gln Glu Gly Val Ser Ala Glu Asn Pro Val 
545                 550                 555                 560 


Glu Asn His Ile Asn Ile Thr Gln Ser Asp Lys Phe Thr Ala Lys Pro 
                565                 570                 575     


Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp Leu Asn Leu Asp Arg Ser 
            580                 585                 590         


Cys Gly Val Pro Glu Glu Ser Ala Ser Ser Glu Lys Ala Lys Glu Pro 
        595                 600                 605             


Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser Ala Thr Asn Glu Asn Asn 
    610                 615                 620                 


Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu Ala Thr Gly Pro Ser Ala 
625                 630                 635                 640 


His Glu Glu Thr Ser Thr Arg Asp Ser Ala Leu Gln Asp Thr Asp Asp 
                645                 650                 655     


Ser Asp Asp Asp Pro Val Leu Ile Pro Gly Ala Arg Tyr Arg Ala Gly 
            660                 665                 670         


Pro Gly Asp Arg Arg Ser Ala Val Ala Arg Ile Gln Glu Phe Phe Arg 
        675                 680                 685             


Arg Arg Lys Glu Arg Lys Glu Met Glu Glu Leu Asp Thr Leu Asn Ile 
    690                 695                 700                 


Arg Arg Pro Leu Val Lys Met Val Tyr Lys Gly His Arg Asn Ser Arg 
705                 710                 715                 720 


Thr Met Ile Lys Glu Ala Asn Phe Trp Gly Ala Asn Phe Val Met Ser 
                725                 730                 735     


Gly Ser Asp Cys Gly His Ile Phe Ile Trp Asp Arg His Thr Ala Glu 
            740                 745                 750         


His Leu Met Leu Leu Glu Ala Asp Asn His Val Val Asn Cys Leu Gln 
        755                 760                 765             


Pro His Pro Phe Asp Pro Ile Leu Ala Ser Ser Gly Ile Asp Tyr Asp 
    770                 775                 780                 


Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser Arg Ile Phe Asn Arg Lys 
785                 790                 795                 800 


Leu Ala Asp Glu Val Ile Thr Arg Asn Glu Leu Met Leu Glu Glu Thr 
                805                 810                 815     


Arg Asn Thr Ile Thr Val Pro Ala Ser Phe Met Leu Arg Met Leu Ala 
            820                 825                 830         


Ser Leu Asn His Ile Arg Ala Asp Arg Leu Glu Gly Asp Arg Ser Glu 
        835                 840                 845             


Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp Glu Glu 
    850                 855                 860 


<210>  2900
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF7__Homo_sapiens__NP_005819

<400>  2900

Met Ser Leu His Gly Lys Arg Lys Glu Ile Tyr Lys Tyr Glu Ala Pro 
1               5                   10                  15      


Trp Thr Val Tyr Ala Met Asn Trp Ser Val Arg Pro Asp Lys Arg Phe 
            20                  25                  30          


Arg Leu Ala Leu Gly Ser Phe Val Glu Glu Tyr Asn Asn Lys Val Gln 
        35                  40                  45              


Leu Val Gly Leu Asp Glu Glu Ser Ser Glu Phe Ile Cys Arg Asn Thr 
    50                  55                  60                  


Phe Asp His Pro Tyr Pro Thr Thr Lys Leu Met Trp Ile Pro Asp Thr 
65                  70                  75                  80  


Lys Gly Val Tyr Pro Asp Leu Leu Ala Thr Ser Gly Asp Tyr Leu Arg 
                85                  90                  95      


Val Trp Arg Val Gly Glu Thr Glu Thr Arg Leu Glu Cys Leu Leu Asn 
            100                 105                 110         


Asn Asn Lys Asn Ser Asp Phe Cys Ala Pro Leu Thr Ser Phe Asp Trp 
        115                 120                 125             


Asn Glu Val Asp Pro Tyr Leu Leu Gly Thr Ser Ser Ile Asp Thr Thr 
    130                 135                 140                 


Cys Thr Ile Trp Gly Leu Glu Thr Gly Gln Val Leu Gly Arg Val Asn 
145                 150                 155                 160 


Leu Val Ser Gly His Val Lys Thr Gln Leu Ile Ala His Asp Lys Glu 
                165                 170                 175     


Val Tyr Asp Ile Ala Phe Ser Arg Ala Gly Gly Gly Arg Asp Met Phe 
            180                 185                 190         


Ala Ser Val Gly Ala Asp Gly Ser Val Arg Met Phe Asp Leu Arg His 
        195                 200                 205             


Leu Glu His Ser Thr Ile Ile Tyr Glu Asp Pro Gln His His Pro Leu 
    210                 215                 220                 


Leu Arg Leu Cys Trp Asn Lys Gln Asp Pro Asn Tyr Leu Ala Thr Met 
225                 230                 235                 240 


Ala Met Asp Gly Met Glu Val Val Ile Leu Asp Val Arg Val Pro Cys 
                245                 250                 255     


Thr Pro Val Ala Arg Leu Asn Asn His Arg Ala Cys Val Asn Gly Ile 
            260                 265                 270         


Ala Trp Ala Pro His Ser Ser Cys His Ile Cys Thr Ala Ala Asp Asp 
        275                 280                 285             


His Gln Ala Leu Ile Trp Asp Ile Gln Gln Met Pro Arg Ala Ile Glu 
    290                 295                 300                 


Asp Pro Ile Leu Ala Tyr Thr Ala Glu Gly Glu Ile Asn Asn Val Gln 
305                 310                 315                 320 


Trp Ala Ser Thr Gln Pro Asp Trp Ile Ala Ile Cys Tyr Asn Asn Cys 
                325                 330                 335     


Leu Glu Ile Leu Arg Val 
            340         


<210>  2901
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCAF8__Homo_sapiens__NP_056541

<400>  2901

Met Ser Ser Lys Gly Ser Ser Thr Asp Gly Arg Thr Asp Leu Ala Asn 
1               5                   10                  15      


Gly Ser Leu Ser Ser Ser Pro Glu Glu Met Ser Gly Ala Glu Glu Gly 
            20                  25                  30          


Arg Glu Thr Ser Ser Gly Ile Glu Val Glu Ala Ser Asp Leu Ser Leu 
        35                  40                  45              


Ser Leu Thr Gly Asp Asp Gly Gly Pro Asn Arg Thr Ser Thr Glu Ser 
    50                  55                  60                  


Arg Gly Thr Asp Thr Glu Ser Ser Gly Glu Asp Lys Asp Ser Asp Ser 
65                  70                  75                  80  


Met Glu Asp Thr Gly His Tyr Ser Ile Asn Asp Glu Asn Arg Val His 
                85                  90                  95      


Asp Arg Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Gln Pro Arg Arg Arg Val Gln Arg Lys Arg Ala Asn Arg Asp Gln Asp 
        115                 120                 125             


Ser Ser Asp Asp Glu Arg Ala Leu Glu Asp Trp Val Ser Ser Glu Thr 
    130                 135                 140                 


Ser Ala Leu Pro Arg Pro Arg Trp Gln Ala Leu Pro Ala Leu Arg Glu 
145                 150                 155                 160 


Arg Glu Leu Gly Ser Ser Ala Arg Phe Val Tyr Glu Ala Cys Gly Ala 
                165                 170                 175     


Arg Val Phe Val Gln Arg Phe Arg Leu Gln His Gly Leu Glu Gly His 
            180                 185                 190         


Thr Gly Cys Val Asn Thr Leu His Phe Asn Gln Arg Gly Thr Trp Leu 
        195                 200                 205             


Ala Ser Gly Ser Asp Asp Leu Lys Val Val Val Trp Asp Trp Val Arg 
    210                 215                 220                 


Arg Gln Pro Val Leu Asp Phe Glu Ser Gly His Lys Ser Asn Val Phe 
225                 230                 235                 240 


Gln Ala Lys Phe Leu Pro Asn Ser Gly Asp Ser Thr Leu Ala Met Cys 
                245                 250                 255     


Ala Arg Asp Gly Gln Val Arg Val Ala Glu Leu Ser Ala Thr Gln Cys 
            260                 265                 270         


Cys Lys Asn Thr Lys Arg Val Ala Gln His Lys Gly Ala Ser His Lys 
        275                 280                 285             


Leu Ala Leu Glu Pro Asp Ser Pro Cys Thr Phe Leu Ser Ala Gly Glu 
    290                 295                 300                 


Asp Ala Val Val Phe Thr Ile Asp Leu Arg Gln Asp Arg Pro Ala Ser 
305                 310                 315                 320 


Lys Leu Val Val Thr Lys Glu Lys Glu Lys Lys Val Gly Leu Tyr Thr 
                325                 330                 335     


Ile Tyr Val Asn Pro Ala Asn Thr His Gln Phe Ala Val Gly Gly Arg 
            340                 345                 350         


Asp Gln Phe Val Arg Ile Tyr Asp Gln Arg Lys Ile Asp Glu Asn Glu 
        355                 360                 365             


Asn Asn Gly Val Leu Lys Lys Phe Cys Pro His His Leu Val Asn Ser 
    370                 375                 380                 


Glu Ser Lys Ala Asn Ile Thr Cys Leu Val Tyr Ser His Asp Gly Thr 
385                 390                 395                 400 


Glu Leu Leu Ala Ser Tyr Asn Asp Glu Asp Ile Tyr Leu Phe Asn Ser 
                405                 410                 415     


Ser His Ser Asp Gly Ala Gln Tyr Val Lys Arg Tyr Lys Gly His Arg 
            420                 425                 430         


Asn Asn Ala Thr Val Lys Gly Val Asn Phe Tyr Gly Pro Lys Ser Glu 
        435                 440                 445             


Phe Val Val Ser Gly Ser Asp Cys Gly His Ile Phe Leu Trp Glu Lys 
    450                 455                 460                 


Ser Ser Cys Gln Ile Ile Gln Phe Met Glu Gly Asp Lys Gly Gly Val 
465                 470                 475                 480 


Val Asn Cys Leu Glu Pro His Pro His Leu Pro Val Leu Ala Thr Ser 
                485                 490                 495     


Gly Leu Asp His Asp Val Lys Ile Trp Ala Pro Thr Ala Glu Ala Ser 
            500                 505                 510         


Thr Glu Leu Thr Gly Leu Lys Asp Val Ile Lys Lys Asn Lys Arg Glu 
        515                 520                 525             


Arg Asp Glu Asp Ser Leu His Gln Thr Asp Leu Phe Asp Ser His Met 
    530                 535                 540                 


Leu Trp Phe Leu Met His His Leu Arg Gln Arg Arg His His Arg Arg 
545                 550                 555                 560 


Trp Arg Glu Pro Gly Val Gly Ala Thr Asp Ala Asp Ser Asp Glu Ser 
                565                 570                 575     


Pro Ser Ser Ser Asp Thr Ser Asp Glu Glu Glu Gly Pro Asp Arg Val 
            580                 585                 590         


Gln Cys Met Pro Ser 
        595         


<210>  2902
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCANP1__Homo_sapiens__NP_570900

<400>  2902

Met His Tyr Gly Ala Ala Thr His Ile Gln Asn Ser Arg Ser His Gly 
1               5                   10                  15      


Leu Glu Thr Val Pro Gly His Gln Arg Leu Glu Arg Gly Ala Gly Gly 
            20                  25                  30          


Glu Thr Pro Glu Phe Pro Gly Cys His Ser Pro Ala Pro Pro Glu Asn 
        35                  40                  45              


Phe Gly Asn Glu Leu Leu Pro Leu Ser Ala Pro Leu Gln Gly Leu Ser 
    50                  55                  60                  


Glu Gly Leu Tyr Pro Pro Gly Arg Asn Lys Thr Leu Pro Ala Gly Val 
65                  70                  75                  80  


Leu Arg Glu Gly Ala Val Gln Phe Leu His Arg Gly Leu Cys Asn Ser 
                85                  90                  95      


Asn Leu Ser Ser Glu Ala Ser Ala Arg Pro Ser Gly Thr Gln Asp Glu 
            100                 105                 110         


Leu His Ser Ser Arg Arg Lys Thr Gly Gln Thr Arg Arg Glu Gly Ala 
        115                 120                 125             


Arg Lys His Leu Val Cys Ser Phe Arg Leu Tyr Pro Phe Thr Val His 
    130                 135                 140                 


Thr Val Ser Pro Gly Asn Ser His Leu Ala Leu Tyr Gln Val Phe Lys 
145                 150                 155                 160 


Ala Val Lys Leu Cys Pro Ser Glu Thr Ser Phe Phe Leu Ser Arg Lys 
                165                 170                 175     


Ser Leu Lys Ser Ser Asp Pro Trp His Pro Pro Ser Leu Ser Pro Asn 
            180                 185                 190         


Ser Trp Asn Arg Gln Ala Gly Phe Arg Ala Trp Ser Ser His Leu Ile 
        195                 200                 205             


Ser Leu Ser Leu Thr Cys Ser Asp Ser Gln Ser Arg Arg Val Ser Ser 
    210                 215                 220                 


Ser Gln Gln Pro Pro Leu His Ser Leu Ser Ser His Arg Arg Ala Ala 
225                 230                 235                 240 


His Val Pro Glu 
                


<210>  2903
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCBLD1__Homo_sapiens__NP_775945

<400>  2903

Met Val Pro Gly Ala Arg Gly Gly Gly Ala Leu Ala Arg Ala Ala Gly 
1               5                   10                  15      


Arg Gly Leu Leu Ala Leu Leu Leu Ala Val Ser Ala Pro Leu Arg Leu 
            20                  25                  30          


Gln Ala Glu Glu Leu Gly Asp Gly Cys Gly His Leu Val Thr Tyr Gln 
        35                  40                  45              


Asp Ser Gly Thr Met Thr Ser Lys Asn Tyr Pro Gly Thr Tyr Pro Asn 
    50                  55                  60                  


His Thr Val Cys Glu Lys Thr Ile Thr Val Pro Lys Gly Lys Arg Leu 
65                  70                  75                  80  


Ile Leu Arg Leu Gly Asp Leu Asp Ile Glu Ser Gln Thr Cys Ala Ser 
                85                  90                  95      


Asp Tyr Leu Leu Phe Thr Ser Ser Ser Asp Gln Tyr Gly Pro Tyr Cys 
            100                 105                 110         


Gly Ser Met Thr Val Pro Lys Glu Leu Leu Leu Asn Thr Ser Glu Val 
        115                 120                 125             


Thr Val Arg Phe Glu Ser Gly Ser His Ile Ser Gly Arg Gly Phe Leu 
    130                 135                 140                 


Leu Thr Tyr Ala Ser Ser Asp His Pro Asp Leu Ile Thr Cys Leu Glu 
145                 150                 155                 160 


Arg Ala Ser His Tyr Leu Lys Thr Glu Tyr Ser Lys Phe Cys Pro Ala 
                165                 170                 175     


Gly Cys Arg Asp Val Ala Gly Asp Ile Ser Gly Asn Met Val Asp Gly 
            180                 185                 190         


Tyr Arg Asp Thr Ser Leu Leu Cys Lys Ala Ala Ile His Ala Gly Ile 
        195                 200                 205             


Ile Ala Asp Glu Leu Gly Gly Gln Ile Ser Val Leu Gln Arg Lys Gly 
    210                 215                 220                 


Ile Ser Arg Tyr Glu Gly Ile Leu Ala Asn Gly Val Leu Ser Arg Asp 
225                 230                 235                 240 


Gly Ser Leu Ser Asp Lys Arg Phe Leu Phe Thr Ser Asn Gly Cys Ser 
                245                 250                 255     


Arg Ser Leu Ser Phe Glu Pro Asp Gly Gln Ile Arg Ala Ser Ser Ser 
            260                 265                 270         


Trp Gln Ser Val Asn Glu Ser Gly Asp Gln Val His Trp Ser Pro Gly 
        275                 280                 285             


Gln Ala Arg Leu Gln Asp Gln Gly Pro Ser Trp Ala Ser Gly Asp Ser 
    290                 295                 300                 


Ser Asn Asn His Lys Pro Arg Glu Trp Leu Glu Ile Asp Leu Gly Glu 
305                 310                 315                 320 


Lys Lys Lys Ile Thr Gly Ile Arg Thr Thr Gly Ser Thr Gln Ser Asn 
                325                 330                 335     


Phe Asn Phe Tyr Val Lys Ser Phe Val Met Asn Phe Lys Asn Asn Asn 
            340                 345                 350         


Ser Lys Trp Lys Thr Tyr Lys Gly Ile Val Asn Asn Glu Glu Lys Val 
        355                 360                 365             


Phe Gln Gly Asn Ser Asn Phe Arg Asp Pro Val Gln Asn Asn Phe Ile 
    370                 375                 380                 


Pro Pro Ile Val Ala Arg Tyr Val Arg Val Val Pro Gln Thr Trp His 
385                 390                 395                 400 


Gln Arg Ile Ala Leu Lys Val Glu Leu Ile Gly Cys Gln Ile Thr Gln 
                405                 410                 415     


Gly Asn Asp Ser Leu Val Trp Arg Lys Thr Ser Gln Ser Thr Ser Val 
            420                 425                 430         


Ser Thr Lys Lys Glu Asp Glu Thr Ile Thr Arg Pro Ile Pro Ser Glu 
        435                 440                 445             


Glu Thr Ser Thr Gly Ile Asn Ile Thr Thr Val Ala Ile Pro Leu Val 
    450                 455                 460                 


Leu Leu Val Val Leu Val Phe Ala Gly Met Gly Ile Phe Ala Ala Phe 
465                 470                 475                 480 


Arg Lys Lys Lys Lys Lys Gly Ser Pro Tyr Gly Ser Ala Glu Ala Gln 
                485                 490                 495     


Lys Thr Asp Cys Trp Lys Gln Ile Lys Tyr Pro Phe Ala Arg His Gln 
            500                 505                 510         


Ser Ala Glu Phe Thr Ile Ser Tyr Asp Asn Glu Lys Glu Met Thr Gln 
        515                 520                 525             


Lys Leu Asp Leu Ile Thr Ser Asp Met Ala Gly 
    530                 535                 


<210>  2904
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCBLD2__Homo_sapiens__NP_563615

<400>  2904

Met Ala Ser Arg Ala Val Val Arg Ala Arg Arg Cys Pro Gln Cys Pro 
1               5                   10                  15      


Gln Val Arg Ala Ala Ala Ala Ala Pro Ala Trp Ala Ala Leu Pro Leu 
            20                  25                  30          


Ser Arg Ser Leu Pro Pro Cys Ser Asn Ser Ser Ser Phe Ser Met Pro 
        35                  40                  45              


Leu Phe Leu Leu Leu Leu Leu Val Leu Leu Leu Leu Leu Glu Asp Ala 
    50                  55                  60                  


Gly Ala Gln Gln Gly Asp Gly Cys Gly His Thr Val Leu Gly Pro Glu 
65                  70                  75                  80  


Ser Gly Thr Leu Thr Ser Ile Asn Tyr Pro Gln Thr Tyr Pro Asn Ser 
                85                  90                  95      


Thr Val Cys Glu Trp Glu Ile Arg Val Lys Met Gly Glu Arg Val Arg 
            100                 105                 110         


Ile Lys Phe Gly Asp Phe Asp Ile Glu Asp Ser Asp Ser Cys His Phe 
        115                 120                 125             


Asn Tyr Leu Arg Ile Tyr Asn Gly Ile Gly Val Ser Arg Thr Glu Ile 
    130                 135                 140                 


Gly Lys Tyr Cys Gly Leu Gly Leu Gln Met Asn His Ser Ile Glu Ser 
145                 150                 155                 160 


Lys Gly Asn Glu Ile Thr Leu Leu Phe Met Ser Gly Ile His Val Ser 
                165                 170                 175     


Gly Arg Gly Phe Leu Ala Ser Tyr Ser Val Ile Asp Lys Gln Asp Leu 
            180                 185                 190         


Ile Thr Cys Leu Asp Thr Ala Ser Asn Phe Leu Glu Pro Glu Phe Ser 
        195                 200                 205             


Lys Tyr Cys Pro Ala Gly Cys Leu Leu Pro Phe Ala Glu Ile Ser Gly 
    210                 215                 220                 


Thr Ile Pro His Gly Tyr Arg Asp Ser Ser Pro Leu Cys Met Ala Gly 
225                 230                 235                 240 


Val His Ala Gly Val Val Ser Asn Thr Leu Gly Gly Gln Ile Ser Val 
                245                 250                 255     


Val Ile Ser Lys Gly Ile Pro Tyr Tyr Glu Ser Ser Leu Ala Asn Asn 
            260                 265                 270         


Val Thr Ser Val Val Gly His Leu Ser Thr Ser Leu Phe Thr Phe Lys 
        275                 280                 285             


Thr Ser Gly Cys Tyr Gly Thr Leu Gly Met Glu Ser Gly Val Ile Ala 
    290                 295                 300                 


Asp Pro Gln Ile Thr Ala Ser Ser Val Leu Glu Trp Thr Asp His Thr 
305                 310                 315                 320 


Gly Gln Glu Asn Ser Trp Lys Pro Lys Lys Ala Arg Leu Lys Lys Pro 
                325                 330                 335     


Gly Pro Pro Trp Ala Ala Phe Ala Thr Asp Glu Tyr Gln Trp Leu Gln 
            340                 345                 350         


Ile Asp Leu Asn Lys Glu Lys Lys Ile Thr Gly Ile Ile Thr Thr Gly 
        355                 360                 365             


Ser Thr Met Val Glu His Asn Tyr Tyr Val Ser Ala Tyr Arg Ile Leu 
    370                 375                 380                 


Tyr Ser Asp Asp Gly Gln Lys Trp Thr Val Tyr Arg Glu Pro Gly Val 
385                 390                 395                 400 


Glu Gln Asp Lys Ile Phe Gln Gly Asn Lys Asp Tyr His Gln Asp Val 
                405                 410                 415     


Arg Asn Asn Phe Leu Pro Pro Ile Ile Ala Arg Phe Ile Arg Val Asn 
            420                 425                 430         


Pro Thr Gln Trp Gln Gln Lys Ile Ala Met Lys Met Glu Leu Leu Gly 
        435                 440                 445             


Cys Gln Phe Ile Pro Lys Gly Arg Pro Pro Lys Leu Thr Gln Pro Pro 
    450                 455                 460                 


Pro Pro Arg Asn Ser Asn Asp Leu Lys Asn Thr Thr Ala Pro Pro Lys 
465                 470                 475                 480 


Ile Ala Lys Gly Arg Ala Pro Lys Phe Thr Gln Pro Leu Gln Pro Arg 
                485                 490                 495     


Ser Ser Asn Glu Phe Pro Ala Gln Thr Glu Gln Thr Thr Ala Ser Pro 
            500                 505                 510         


Asp Ile Arg Asn Thr Thr Val Thr Pro Asn Val Thr Lys Asp Val Ala 
        515                 520                 525             


Leu Ala Ala Val Leu Val Pro Val Leu Val Met Val Leu Thr Thr Leu 
    530                 535                 540                 


Ile Leu Ile Leu Val Cys Ala Trp His Trp Arg Asn Arg Lys Lys Lys 
545                 550                 555                 560 


Thr Glu Gly Thr Tyr Asp Leu Pro Tyr Trp Asp Arg Ala Gly Trp Trp 
                565                 570                 575     


Lys Gly Met Lys Gln Phe Leu Pro Ala Lys Ala Val Asp His Glu Glu 
            580                 585                 590         


Thr Pro Val Arg Tyr Ser Ser Ser Glu Val Asn His Leu Ser Pro Arg 
        595                 600                 605             


Glu Val Thr Thr Val Leu Gln Ala Asp Ser Ala Glu Tyr Ala Gln Pro 
    610                 615                 620                 


Leu Val Gly Gly Ile Val Gly Thr Leu His Gln Arg Ser Thr Phe Lys 
625                 630                 635                 640 


Pro Glu Glu Gly Lys Glu Ala Gly Tyr Ala Asp Leu Asp Pro Tyr Asn 
                645                 650                 655     


Ser Pro Gly Gln Glu Val Tyr His Ala Tyr Ala Glu Pro Leu Pro Ile 
            660                 665                 670         


Thr Gly Pro Glu Tyr Ala Thr Pro Ile Ile Met Asp Met Ser Gly His 
        675                 680                 685             


Pro Thr Thr Ser Val Gly Gln Pro Ser Thr Ser Thr Phe Lys Ala Thr 
    690                 695                 700                 


Gly Asn Gln Pro Pro Pro Leu Val Gly Thr Tyr Asn Thr Leu Leu Ser 
705                 710                 715                 720 


Arg Thr Asp Ser Cys Ser Ser Ala Gln Ala Gln Tyr Asp Thr Pro Lys 
                725                 730                 735     


Ala Gly Lys Pro Gly Leu Pro Ala Pro Asp Glu Leu Val Tyr Gln Val 
            740                 745                 750         


Pro Gln Ser Thr Gln Glu Val Ser Gly Ala Gly Arg Asp Gly Glu Cys 
        755                 760                 765             


Asp Val Phe Lys Glu Ile Leu 
    770                 775 


<210>  2905
<211>  1447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCC__Homo_sapiens__NP_005206

<400>  2905

Met Glu Asn Ser Leu Arg Cys Val Trp Val Pro Lys Leu Ala Phe Val 
1               5                   10                  15      


Leu Phe Gly Ala Ser Leu Phe Ser Ala His Leu Gln Val Thr Gly Phe 
            20                  25                  30          


Gln Ile Lys Ala Phe Thr Ala Leu Arg Phe Leu Ser Glu Pro Ser Asp 
        35                  40                  45              


Ala Val Thr Met Arg Gly Gly Asn Val Leu Leu Asp Cys Ser Ala Glu 
    50                  55                  60                  


Ser Asp Arg Gly Val Pro Val Ile Lys Trp Lys Lys Asp Gly Ile His 
65                  70                  75                  80  


Leu Ala Leu Gly Met Asp Glu Arg Lys Gln Gln Leu Ser Asn Gly Ser 
                85                  90                  95      


Leu Leu Ile Gln Asn Ile Leu His Ser Arg His His Lys Pro Asp Glu 
            100                 105                 110         


Gly Leu Tyr Gln Cys Glu Ala Ser Leu Gly Asp Ser Gly Ser Ile Ile 
        115                 120                 125             


Ser Arg Thr Ala Lys Val Ala Val Ala Gly Pro Leu Arg Phe Leu Ser 
    130                 135                 140                 


Gln Thr Glu Ser Val Thr Ala Phe Met Gly Asp Thr Val Leu Leu Lys 
145                 150                 155                 160 


Cys Glu Val Ile Gly Glu Pro Met Pro Thr Ile His Trp Gln Lys Asn 
                165                 170                 175     


Gln Gln Asp Leu Thr Pro Ile Pro Gly Asp Ser Arg Val Val Val Leu 
            180                 185                 190         


Pro Ser Gly Ala Leu Gln Ile Ser Arg Leu Gln Pro Gly Asp Ile Gly 
        195                 200                 205             


Ile Tyr Arg Cys Ser Ala Arg Asn Pro Ala Ser Ser Arg Thr Gly Asn 
    210                 215                 220                 


Glu Ala Glu Val Arg Ile Leu Ser Asp Pro Gly Leu His Arg Gln Leu 
225                 230                 235                 240 


Tyr Phe Leu Gln Arg Pro Ser Asn Val Val Ala Ile Glu Gly Lys Asp 
                245                 250                 255     


Ala Val Leu Glu Cys Cys Val Ser Gly Tyr Pro Pro Pro Ser Phe Thr 
            260                 265                 270         


Trp Leu Arg Gly Glu Glu Val Ile Gln Leu Arg Ser Lys Lys Tyr Ser 
        275                 280                 285             


Leu Leu Gly Gly Ser Asn Leu Leu Ile Ser Asn Val Thr Asp Asp Asp 
    290                 295                 300                 


Ser Gly Met Tyr Thr Cys Val Val Thr Tyr Lys Asn Glu Asn Ile Ser 
305                 310                 315                 320 


Ala Ser Ala Glu Leu Thr Val Leu Val Pro Pro Trp Phe Leu Asn His 
                325                 330                 335     


Pro Ser Asn Leu Tyr Ala Tyr Glu Ser Met Asp Ile Glu Phe Glu Cys 
            340                 345                 350         


Thr Val Ser Gly Lys Pro Val Pro Thr Val Asn Trp Met Lys Asn Gly 
        355                 360                 365             


Asp Val Val Ile Pro Ser Asp Tyr Phe Gln Ile Val Gly Gly Ser Asn 
    370                 375                 380                 


Leu Arg Ile Leu Gly Val Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys 
385                 390                 395                 400 


Val Ala Glu Asn Glu Ala Gly Asn Ala Gln Thr Ser Ala Gln Leu Ile 
                405                 410                 415     


Val Pro Lys Pro Ala Ile Pro Ser Ser Ser Val Leu Pro Ser Ala Pro 
            420                 425                 430         


Arg Asp Val Val Pro Val Leu Val Ser Ser Arg Phe Val Arg Leu Ser 
        435                 440                 445             


Trp Arg Pro Pro Ala Glu Ala Lys Gly Asn Ile Gln Thr Phe Thr Val 
    450                 455                 460                 


Phe Phe Ser Arg Glu Gly Asp Asn Arg Glu Arg Ala Leu Asn Thr Thr 
465                 470                 475                 480 


Gln Pro Gly Ser Leu Gln Leu Thr Val Gly Asn Leu Lys Pro Glu Ala 
                485                 490                 495     


Met Tyr Thr Phe Arg Val Val Ala Tyr Asn Glu Trp Gly Pro Gly Glu 
            500                 505                 510         


Ser Ser Gln Pro Ile Lys Val Ala Thr Gln Pro Glu Leu Gln Val Pro 
        515                 520                 525             


Gly Pro Val Glu Asn Leu Gln Ala Val Ser Thr Ser Pro Thr Ser Ile 
    530                 535                 540                 


Leu Ile Thr Trp Glu Pro Pro Ala Tyr Ala Asn Gly Pro Val Gln Gly 
545                 550                 555                 560 


Tyr Arg Leu Phe Cys Thr Glu Val Ser Thr Gly Lys Glu Gln Asn Ile 
                565                 570                 575     


Glu Val Asp Gly Leu Ser Tyr Lys Leu Glu Gly Leu Lys Lys Phe Thr 
            580                 585                 590         


Glu Tyr Ser Leu Arg Phe Leu Ala Tyr Asn Arg Tyr Gly Pro Gly Val 
        595                 600                 605             


Ser Thr Asp Asp Ile Thr Val Val Thr Leu Ser Asp Val Pro Ser Ala 
    610                 615                 620                 


Pro Pro Gln Asn Val Ser Leu Glu Val Val Asn Ser Arg Ser Ile Lys 
625                 630                 635                 640 


Val Ser Trp Leu Pro Pro Pro Ser Gly Thr Gln Asn Gly Phe Ile Thr 
                645                 650                 655     


Gly Tyr Lys Ile Arg His Arg Lys Thr Thr Arg Arg Gly Glu Met Glu 
            660                 665                 670         


Thr Leu Glu Pro Asn Asn Leu Trp Tyr Leu Phe Thr Gly Leu Glu Lys 
        675                 680                 685             


Gly Ser Gln Tyr Ser Phe Gln Val Ser Ala Met Thr Val Asn Gly Thr 
    690                 695                 700                 


Gly Pro Pro Ser Asn Trp Tyr Thr Ala Glu Thr Pro Glu Asn Asp Leu 
705                 710                 715                 720 


Asp Glu Ser Gln Val Pro Asp Gln Pro Ser Ser Leu His Val Arg Pro 
                725                 730                 735     


Gln Thr Asn Cys Ile Ile Met Ser Trp Thr Pro Pro Leu Asn Pro Asn 
            740                 745                 750         


Ile Val Val Arg Gly Tyr Ile Ile Gly Tyr Gly Val Gly Ser Pro Tyr 
        755                 760                 765             


Ala Glu Thr Val Arg Val Asp Ser Lys Gln Arg Tyr Tyr Ser Ile Glu 
    770                 775                 780                 


Arg Leu Glu Ser Ser Ser His Tyr Val Ile Ser Leu Lys Ala Phe Asn 
785                 790                 795                 800 


Asn Ala Gly Glu Gly Val Pro Leu Tyr Glu Ser Ala Thr Thr Arg Ser 
                805                 810                 815     


Ile Thr Asp Pro Thr Asp Pro Val Asp Tyr Tyr Pro Leu Leu Asp Asp 
            820                 825                 830         


Phe Pro Thr Ser Val Pro Asp Leu Ser Thr Pro Met Leu Pro Pro Val 
        835                 840                 845             


Gly Val Gln Ala Val Ala Leu Thr His Asp Ala Val Arg Val Ser Trp 
    850                 855                 860                 


Ala Asp Asn Ser Val Pro Lys Asn Gln Lys Thr Ser Glu Val Arg Leu 
865                 870                 875                 880 


Tyr Thr Val Arg Trp Arg Thr Ser Phe Ser Ala Ser Ala Lys Tyr Lys 
                885                 890                 895     


Ser Glu Asp Thr Thr Ser Leu Ser Tyr Thr Ala Thr Gly Leu Lys Pro 
            900                 905                 910         


Asn Thr Met Tyr Glu Phe Ser Val Met Val Thr Lys Asn Arg Arg Ser 
        915                 920                 925             


Ser Thr Trp Ser Met Thr Ala His Ala Thr Thr Tyr Glu Ala Ala Pro 
    930                 935                 940                 


Thr Ser Ala Pro Lys Asp Leu Thr Val Ile Thr Arg Glu Gly Lys Pro 
945                 950                 955                 960 


Arg Ala Val Ile Val Ser Trp Gln Pro Pro Leu Glu Ala Asn Gly Lys 
                965                 970                 975     


Ile Thr Ala Tyr Ile Leu Phe Tyr Thr Leu Asp Lys Asn Ile Pro Ile 
            980                 985                 990         


Asp Asp Trp Ile Met Glu Thr Ile  Ser Gly Asp Arg Leu  Thr His Gln 
        995                 1000                 1005             


Ile Met  Asp Leu Asn Leu Asp  Thr Met Tyr Tyr Phe  Arg Ile Gln 
    1010                 1015                 1020             


Ala Arg  Asn Ser Lys Gly Val  Gly Pro Leu Ser Asp  Pro Ile Leu 
    1025                 1030                 1035             


Phe Arg  Thr Leu Lys Val Glu  His Pro Asp Lys Met  Ala Asn Asp 
    1040                 1045                 1050             


Gln Gly  Arg His Gly Asp Gly  Gly Tyr Trp Pro Val  Asp Thr Asn 
    1055                 1060                 1065             


Leu Ile  Asp Arg Ser Thr Leu  Asn Glu Pro Pro Ile  Gly Gln Met 
    1070                 1075                 1080             


His Pro  Pro His Gly Ser Val  Thr Pro Gln Lys Asn  Ser Asn Leu 
    1085                 1090                 1095             


Leu Val  Ile Ile Val Val Thr  Val Gly Val Ile Thr  Val Leu Val 
    1100                 1105                 1110             


Val Val  Ile Val Ala Val Ile  Cys Thr Arg Arg Ser  Ser Ala Gln 
    1115                 1120                 1125             


Gln Arg  Lys Lys Arg Ala Thr  His Ser Ala Gly Lys  Arg Lys Gly 
    1130                 1135                 1140             


Ser Gln  Lys Asp Leu Arg Pro  Pro Asp Leu Trp Ile  His His Glu 
    1145                 1150                 1155             


Glu Met  Glu Met Lys Asn Ile  Glu Lys Pro Ser Gly  Thr Asp Pro 
    1160                 1165                 1170             


Ala Gly  Arg Asp Ser Pro Ile  Gln Ser Cys Gln Asp  Leu Thr Pro 
    1175                 1180                 1185             


Val Ser  His Ser Gln Ser Glu  Thr Gln Leu Gly Ser  Lys Ser Thr 
    1190                 1195                 1200             


Ser His  Ser Gly Gln Asp Thr  Glu Glu Ala Gly Ser  Ser Met Ser 
    1205                 1210                 1215             


Thr Leu  Glu Arg Ser Leu Ala  Ala Arg Arg Ala Pro  Arg Ala Lys 
    1220                 1225                 1230             


Leu Met  Ile Pro Met Asp Ala  Gln Ser Asn Asn Pro  Ala Val Val 
    1235                 1240                 1245             


Ser Ala  Ile Pro Val Pro Thr  Leu Glu Ser Ala Gln  Tyr Pro Gly 
    1250                 1255                 1260             


Ile Leu  Pro Ser Pro Thr Cys  Gly Tyr Pro His Pro  Gln Phe Thr 
    1265                 1270                 1275             


Leu Arg  Pro Val Pro Phe Pro  Thr Leu Ser Val Asp  Arg Gly Phe 
    1280                 1285                 1290             


Gly Ala  Gly Arg Ser Gln Ser  Val Ser Glu Gly Pro  Thr Thr Gln 
    1295                 1300                 1305             


Gln Pro  Pro Met Leu Pro Pro  Ser Gln Pro Glu His  Ser Ser Ser 
    1310                 1315                 1320             


Glu Glu  Ala Pro Ser Arg Thr  Ile Pro Thr Ala Cys  Val Arg Pro 
    1325                 1330                 1335             


Thr His  Pro Leu Arg Ser Phe  Ala Asn Pro Leu Leu  Pro Pro Pro 
    1340                 1345                 1350             


Met Ser  Ala Ile Glu Pro Lys  Val Pro Tyr Thr Pro  Leu Leu Ser 
    1355                 1360                 1365             


Gln Pro  Gly Pro Thr Leu Pro  Lys Thr His Val Lys  Thr Ala Ser 
    1370                 1375                 1380             


Leu Gly  Leu Ala Gly Lys Ala  Arg Ser Pro Leu Leu  Pro Val Ser 
    1385                 1390                 1395             


Val Pro  Thr Ala Pro Glu Val  Ser Glu Glu Ser His  Lys Pro Thr 
    1400                 1405                 1410             


Glu Asp  Ser Ala Asn Val Tyr  Glu Gln Asp Asp Leu  Ser Glu Gln 
    1415                 1420                 1425             


Met Ala  Ser Leu Glu Gly Leu  Met Lys Gln Leu Asn  Ala Ile Thr 
    1430                 1435                 1440             


Gly Ser  Ala Phe 
    1445         


<210>  2906
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCDC2C__Homo_sapiens__NP_001274373

<400>  2906

Met Gly Thr Arg Gly Pro Ser Ala Pro Val Asp Thr Thr Pro Ala Lys 
1               5                   10                  15      


Thr Ile Val Val Tyr Arg Asn Gly Asp Pro Phe Tyr Val Gly Lys Lys 
            20                  25                  30          


Phe Val Leu Ser Arg Arg Arg Ala Ala Thr Phe Glu Ala Leu Leu Glu 
        35                  40                  45              


Gln Leu Thr Glu Gln Val Asp Val Pro Phe Gly Val Arg Arg Leu Phe 
    50                  55                  60                  


Thr Pro Thr Arg Gly His Arg Val Leu Gly Leu Asp Ala Leu Gln Ala 
65                  70                  75                  80  


Gly Gly Lys Tyr Val Ala Ala Gly Arg Glu Arg Phe Lys Glu Leu Asp 
                85                  90                  95      


Tyr Ile His Ile Val Pro Arg Lys Pro Ala Lys Ile Arg Lys Leu Lys 
            100                 105                 110         


Glu Ile Lys Pro Val Val His Cys Asp Ile Asn Val Pro Ser Lys Trp 
        115                 120                 125             


Gln Thr Tyr His Arg Ile Ser Arg His Ile Asn Val Phe Thr Asn Gly 
    130                 135                 140                 


Arg Leu Phe Ile Pro Pro Ala Lys Ile Ile Ile Pro Lys Phe Ser Leu 
145                 150                 155                 160 


Ser Asp Trp Asp Ile Val Leu Ala Thr Ile Gly Glu Lys Val Phe Pro 
                165                 170                 175     


Leu Gly Gly Val Arg Lys Leu Phe Thr Met Asn Gly His Leu Leu Gly 
            180                 185                 190         


Asp Ser Lys Asp Leu Gln Asp Asn His Phe Tyr Val Ala Val Gly Leu 
        195                 200                 205             


Glu Thr Phe Lys Tyr Phe Pro Tyr Trp Lys Ser Pro Arg Val Pro Ser 
    210                 215                 220                 


Glu Val Gln Gln Arg Tyr Ala Asn Val Glu Lys Asn Ser Gln Arg Lys 
225                 230                 235                 240 


Lys Lys Val Asp Ser Lys Gly Lys Glu Pro Cys Lys Tyr Asp Gly Ile 
                245                 250                 255     


Pro Pro Lys Thr Gln Asp Ser Val Tyr Tyr Ala Lys Glu Glu Lys Lys 
            260                 265                 270         


Lys Thr Leu Ala Glu Pro Leu Val Gln Arg Gly Ala Glu Gly Asp Val 
        275                 280                 285             


Tyr Lys Ala Pro Thr Pro Ser Lys Glu Thr Gln Gly Ala Leu Asp Val 
    290                 295                 300                 


Lys Glu Glu His Asn Val Gln Leu Glu Val Pro Val Asp Gln Arg Gln 
305                 310                 315                 320 


Ala Glu Ile Val Lys Glu Asp Glu Glu Ile His Glu Asn Thr Pro Asp 
                325                 330                 335     


Phe Glu Gly Asn Lys Asp Lys Glu Asp Ala Arg Leu Cys Glu Asp Val 
            340                 345                 350         


Glu Arg Lys Met Ala Arg Glu Trp Lys Pro Val Asp 
        355                 360                 


<210>  2907
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCDC2__Homo_sapiens__NP_057440

<400>  2907

Met Ser Gly Ser Ser Ala Arg Ser Ser His Leu Ser Gln Pro Val Val 
1               5                   10                  15      


Lys Ser Val Leu Val Tyr Arg Asn Gly Asp Pro Phe Tyr Ala Gly Arg 
            20                  25                  30          


Arg Val Val Ile His Glu Lys Lys Val Ser Ser Phe Glu Val Phe Leu 
        35                  40                  45              


Lys Glu Val Thr Gly Gly Val Gln Ala Pro Phe Gly Ala Val Arg Asn 
    50                  55                  60                  


Ile Tyr Thr Pro Arg Thr Gly His Arg Ile Arg Lys Leu Asp Gln Ile 
65                  70                  75                  80  


Gln Ser Gly Gly Asn Tyr Val Ala Gly Gly Gln Glu Ala Phe Lys Lys 
                85                  90                  95      


Leu Asn Tyr Leu Asp Ile Gly Glu Ile Lys Lys Arg Pro Met Glu Val 
            100                 105                 110         


Val Asn Thr Glu Val Lys Pro Val Ile His Ser Arg Ile Asn Val Ser 
        115                 120                 125             


Ala Arg Phe Arg Lys Pro Leu Gln Glu Pro Cys Thr Ile Phe Leu Ile 
    130                 135                 140                 


Ala Asn Gly Asp Leu Ile Asn Pro Ala Ser Arg Leu Leu Ile Pro Arg 
145                 150                 155                 160 


Lys Thr Leu Asn Gln Trp Asp His Val Leu Gln Met Val Thr Glu Lys 
                165                 170                 175     


Ile Thr Leu Arg Ser Gly Ala Val His Arg Leu Tyr Thr Leu Glu Gly 
            180                 185                 190         


Lys Leu Val Glu Ser Gly Ala Glu Leu Glu Asn Gly Gln Phe Tyr Val 
        195                 200                 205             


Ala Val Gly Arg Asp Lys Phe Lys Lys Leu Pro Tyr Ser Glu Leu Leu 
    210                 215                 220                 


Phe Asp Lys Ser Thr Met Arg Arg Pro Phe Gly Gln Lys Ala Ser Ser 
225                 230                 235                 240 


Leu Pro Pro Ile Val Gly Ser Arg Lys Ser Lys Gly Ser Gly Asn Asp 
                245                 250                 255     


Arg His Ser Lys Ser Thr Val Gly Ser Ser Asp Asn Ser Ser Pro Gln 
            260                 265                 270         


Pro Leu Lys Arg Lys Gly Lys Lys Glu Asp Val Asn Ser Glu Lys Leu 
        275                 280                 285             


Thr Lys Leu Lys Gln Asn Val Lys Leu Lys Asn Ser Gln Glu Thr Ile 
    290                 295                 300                 


Pro Asn Ser Asp Glu Gly Ile Phe Lys Ala Gly Ala Glu Arg Ser Glu 
305                 310                 315                 320 


Thr Arg Gly Ala Ala Glu Val Gln Glu Asp Glu Asp Thr Gln Val Glu 
                325                 330                 335     


Val Pro Val Asp Gln Arg Pro Ala Glu Ile Val Asp Glu Glu Glu Asp 
            340                 345                 350         


Gly Glu Lys Ala Asn Lys Asp Ala Glu Gln Lys Glu Asp Phe Ser Gly 
        355                 360                 365             


Met Asn Gly Asp Leu Glu Glu Glu Gly Gly Arg Glu Ala Thr Asp Ala 
    370                 375                 380                 


Pro Glu Gln Val Glu Glu Ile Leu Asp His Ser Glu Gln Gln Ala Arg 
385                 390                 395                 400 


Pro Ala Arg Val Asn Gly Gly Thr Asp Glu Glu Asn Gly Glu Glu Leu 
                405                 410                 415     


Gln Gln Val Asn Asn Glu Leu Gln Leu Val Leu Asp Lys Glu Arg Lys 
            420                 425                 430         


Ser Gln Gly Ala Gly Ser Gly Gln Asp Glu Ala Asp Val Asp Pro Gln 
        435                 440                 445             


Arg Pro Pro Arg Pro Glu Val Lys Ile Thr Ser Pro Glu Glu Asn Glu 
    450                 455                 460                 


Asn Asn Gln Gln Asn Lys Asp Tyr Ala Ala Val Ala 
465                 470                 475     


<210>  2908
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCD__Homo_sapiens__NP_444513

<400>  2908

Met Arg Phe Met Thr Leu Leu Phe Leu Thr Ala Leu Ala Gly Ala Leu 
1               5                   10                  15      


Val Cys Ala Tyr Asp Pro Glu Ala Ala Ser Ala Pro Gly Ser Gly Asn 
            20                  25                  30          


Pro Cys His Glu Ala Ser Ala Ala Gln Lys Glu Asn Ala Gly Glu Asp 
        35                  40                  45              


Pro Gly Leu Ala Arg Gln Ala Pro Lys Pro Arg Lys Gln Arg Ser Ser 
    50                  55                  60                  


Leu Leu Glu Lys Gly Leu Asp Gly Ala Lys Lys Ala Val Gly Gly Leu 
65                  70                  75                  80  


Gly Lys Leu Gly Lys Asp Ala Val Glu Asp Leu Glu Ser Val Gly Lys 
                85                  90                  95      


Gly Ala Val His Asp Val Lys Asp Val Leu Asp Ser Val Leu 
            100                 105                 110 


<210>  2909
<211>  3298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCHS1__Homo_sapiens__NP_003728

<400>  2909

Met Gln Lys Glu Leu Gly Ile Val Pro Ser Cys Pro Gly Met Lys Ser 
1               5                   10                  15      


Pro Arg Pro His Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Gly Ala Gly Val Pro Gly Ala Trp Gly Gln Ala Gly Ser Leu Asp 
        35                  40                  45              


Leu Gln Ile Asp Glu Glu Gln Pro Ala Gly Thr Leu Ile Gly Asp Ile 
    50                  55                  60                  


Ser Ala Gly Leu Pro Ala Gly Thr Ala Ala Pro Leu Met Tyr Phe Ile 
65                  70                  75                  80  


Ser Ala Gln Glu Gly Ser Gly Val Gly Thr Asp Leu Ala Ile Asp Glu 
                85                  90                  95      


His Ser Gly Val Val Arg Thr Ala Arg Val Leu Asp Arg Glu Gln Arg 
            100                 105                 110         


Asp Arg Tyr Arg Phe Thr Ala Val Thr Pro Asp Gly Ala Thr Val Glu 
        115                 120                 125             


Val Thr Val Arg Val Ala Asp Ile Asn Asp His Ala Pro Ala Phe Pro 
    130                 135                 140                 


Gln Ala Arg Ala Ala Leu Gln Val Pro Glu His Thr Ala Phe Gly Thr 
145                 150                 155                 160 


Arg Tyr Pro Leu Glu Pro Ala Arg Asp Ala Asp Ala Gly Arg Leu Gly 
                165                 170                 175     


Thr Gln Gly Tyr Ala Leu Ser Gly Asp Gly Ala Gly Glu Thr Phe Arg 
            180                 185                 190         


Leu Glu Thr Arg Pro Gly Pro Asp Gly Thr Pro Val Pro Glu Leu Val 
        195                 200                 205             


Val Thr Gly Glu Leu Asp Arg Glu Asn Arg Ser His Tyr Met Leu Gln 
    210                 215                 220                 


Leu Glu Ala Tyr Asp Gly Gly Ser Pro Pro Arg Arg Ala Gln Ala Leu 
225                 230                 235                 240 


Leu Asp Val Thr Leu Leu Asp Ile Asn Asp His Ala Pro Ala Phe Asn 
                245                 250                 255     


Gln Ser Arg Tyr His Ala Val Val Ser Glu Ser Leu Ala Pro Gly Ser 
            260                 265                 270         


Pro Val Leu Gln Val Phe Ala Ser Asp Ala Asp Ala Gly Val Asn Gly 
        275                 280                 285             


Ala Val Thr Tyr Glu Ile Asn Arg Arg Gln Ser Glu Gly Asp Gly Pro 
    290                 295                 300                 


Phe Ser Ile Asp Ala His Thr Gly Leu Leu Gln Leu Glu Arg Pro Leu 
305                 310                 315                 320 


Asp Phe Glu Gln Arg Arg Val His Glu Leu Val Val Gln Ala Arg Asp 
                325                 330                 335     


Gly Gly Ala His Pro Glu Leu Gly Ser Ala Phe Val Thr Val His Val 
            340                 345                 350         


Arg Asp Ala Asn Asp Asn Gln Pro Ser Met Thr Val Ile Phe Leu Ser 
        355                 360                 365             


Ala Asp Gly Ser Pro Gln Val Ser Glu Ala Ala Pro Pro Gly Gln Leu 
    370                 375                 380                 


Val Ala Arg Ile Ser Val Ser Asp Pro Asp Asp Gly Asp Phe Ala His 
385                 390                 395                 400 


Val Asn Val Ser Leu Glu Gly Gly Glu Gly His Phe Ala Leu Ser Thr 
                405                 410                 415     


Gln Asp Ser Val Ile Tyr Leu Val Cys Val Ala Arg Arg Leu Asp Arg 
            420                 425                 430         


Glu Glu Arg Asp Ala Tyr Asn Leu Arg Val Thr Ala Thr Asp Ser Gly 
        435                 440                 445             


Ser Pro Pro Leu Arg Ala Glu Ala Ala Phe Val Leu His Val Thr Asp 
    450                 455                 460                 


Val Asn Asp Asn Ala Pro Ala Phe Asp Arg Gln Leu Tyr Arg Pro Glu 
465                 470                 475                 480 


Pro Leu Pro Glu Val Ala Leu Pro Gly Ser Phe Val Val Arg Val Thr 
                485                 490                 495     


Ala Arg Asp Pro Asp Gln Gly Thr Asn Gly Gln Val Thr Tyr Ser Leu 
            500                 505                 510         


Ala Pro Gly Ala His Thr His Trp Phe Ser Ile Asp Pro Thr Ser Gly 
        515                 520                 525             


Ile Ile Thr Thr Ala Ala Ser Leu Asp Tyr Glu Leu Glu Pro Gln Pro 
    530                 535                 540                 


Gln Leu Ile Val Val Ala Thr Asp Gly Gly Leu Pro Pro Leu Ala Ser 
545                 550                 555                 560 


Ser Ala Thr Val Ser Val Ala Leu Gln Asp Val Asn Asp Asn Glu Pro 
                565                 570                 575     


Gln Phe Gln Arg Thr Phe Tyr Asn Ala Ser Leu Pro Glu Gly Thr Gln 
            580                 585                 590         


Pro Gly Thr Cys Phe Leu Gln Val Thr Ala Thr Asp Ala Asp Ser Gly 
        595                 600                 605             


Pro Phe Gly Leu Leu Ser Tyr Ser Leu Gly Ala Gly Leu Gly Ser Ser 
    610                 615                 620                 


Gly Ser Pro Pro Phe Arg Ile Asp Ala His Ser Gly Asp Val Cys Thr 
625                 630                 635                 640 


Thr Arg Thr Leu Asp Arg Asp Gln Gly Pro Ser Ser Phe Asp Phe Thr 
                645                 650                 655     


Val Thr Ala Val Asp Gly Gly Gly Leu Lys Ser Met Val Tyr Val Lys 
            660                 665                 670         


Val Phe Leu Ser Asp Glu Asn Asp Asn Pro Pro Gln Phe Tyr Pro Arg 
        675                 680                 685             


Glu Tyr Ala Ala Ser Ile Ser Ala Gln Ser Pro Pro Gly Thr Ala Val 
    690                 695                 700                 


Leu Arg Leu Arg Ala His Asp Pro Asp Gln Gly Ser His Gly Arg Leu 
705                 710                 715                 720 


Ser Tyr His Ile Leu Ala Gly Asn Ser Pro Pro Leu Phe Thr Leu Asp 
                725                 730                 735     


Glu Gln Ser Gly Leu Leu Thr Val Ala Trp Pro Leu Ala Arg Arg Ala 
            740                 745                 750         


Asn Ser Val Val Gln Leu Glu Ile Gly Ala Glu Asp Gly Gly Gly Leu 
        755                 760                 765             


Gln Ala Glu Pro Ser Ala Arg Val Asp Ile Ser Ile Val Pro Gly Thr 
    770                 775                 780                 


Pro Thr Pro Pro Ile Phe Glu Gln Leu Gln Tyr Val Phe Ser Val Pro 
785                 790                 795                 800 


Glu Asp Val Ala Pro Gly Thr Ser Val Gly Ile Val Gln Ala His Asn 
                805                 810                 815     


Pro Pro Gly Arg Leu Ala Pro Val Thr Leu Ser Leu Ser Gly Gly Asp 
            820                 825                 830         


Pro Arg Gly Leu Phe Ser Leu Asp Ala Val Ser Gly Leu Leu Gln Thr 
        835                 840                 845             


Leu Arg Pro Leu Asp Arg Glu Leu Leu Gly Pro Val Leu Glu Leu Glu 
    850                 855                 860                 


Val Arg Ala Gly Ser Gly Val Pro Pro Ala Phe Ala Val Ala Arg Val 
865                 870                 875                 880 


Arg Val Leu Leu Asp Asp Val Asn Asp Asn Ser Pro Ala Phe Pro Ala 
                885                 890                 895     


Pro Glu Asp Thr Val Leu Leu Pro Pro Asn Thr Ala Pro Gly Thr Pro 
            900                 905                 910         


Ile Tyr Thr Leu Arg Ala Leu Asp Pro Asp Ser Gly Val Asn Ser Arg 
        915                 920                 925             


Val Thr Phe Thr Leu Leu Ala Gly Gly Gly Gly Ala Phe Thr Val Asp 
    930                 935                 940                 


Pro Thr Thr Gly His Val Arg Leu Met Arg Pro Leu Gly Pro Ser Gly 
945                 950                 955                 960 


Gly Pro Ala His Glu Leu Glu Leu Glu Ala Arg Asp Gly Gly Ser Pro 
                965                 970                 975     


Pro Arg Thr Ser His Phe Arg Leu Arg Val Val Val Gln Asp Val Gly 
            980                 985                 990         


Thr Arg Gly Leu Ala Pro Arg Phe  Asn Ser Pro Thr Tyr  Arg Val Asp 
        995                 1000                 1005             


Leu Pro  Ser Gly Thr Thr Ala  Gly Thr Gln Val Leu  Gln Val Gln 
    1010                 1015                 1020             


Ala Gln  Ala Pro Asp Gly Gly  Pro Ile Thr Tyr His  Leu Ala Ala 
    1025                 1030                 1035             


Glu Gly  Ala Ser Ser Pro Phe  Gly Leu Glu Pro Gln  Ser Gly Trp 
    1040                 1045                 1050             


Leu Trp  Val Arg Ala Ala Leu  Asp Arg Glu Ala Gln  Glu Leu Tyr 
    1055                 1060                 1065             


Ile Leu  Lys Val Met Ala Val  Ser Gly Ser Lys Ala  Glu Leu Gly 
    1070                 1075                 1080             


Gln Gln  Thr Gly Thr Ala Thr  Val Arg Val Ser Ile  Leu Asn Gln 
    1085                 1090                 1095             


Asn Glu  His Ser Pro Arg Leu  Ser Glu Asp Pro Thr  Phe Leu Ala 
    1100                 1105                 1110             


Val Ala  Glu Asn Gln Pro Pro  Gly Thr Ser Val Gly  Arg Val Phe 
    1115                 1120                 1125             


Ala Thr  Asp Arg Asp Ser Gly  Pro Asn Gly Arg Leu  Thr Tyr Ser 
    1130                 1135                 1140             


Leu Gln  Gln Leu Ser Glu Asp  Ser Lys Ala Phe Arg  Ile His Pro 
    1145                 1150                 1155             


Gln Thr  Gly Glu Val Thr Thr  Leu Gln Thr Leu Asp  Arg Glu Gln 
    1160                 1165                 1170             


Gln Ser  Ser Tyr Gln Leu Leu  Val Gln Val Gln Asp  Gly Gly Ser 
    1175                 1180                 1185             


Pro Pro  Arg Ser Thr Thr Gly  Thr Val His Val Ala  Val Leu Asp 
    1190                 1195                 1200             


Leu Asn  Asp Asn Ser Pro Thr  Phe Leu Gln Ala Ser  Gly Ala Ala 
    1205                 1210                 1215             


Gly Gly  Gly Leu Pro Ile Gln  Val Pro Asp Arg Val  Pro Pro Gly 
    1220                 1225                 1230             


Thr Leu  Val Thr Thr Leu Gln  Ala Lys Asp Pro Asp  Glu Gly Glu 
    1235                 1240                 1245             


Asn Gly  Thr Ile Leu Tyr Thr  Leu Thr Gly Pro Gly  Ser Glu Leu 
    1250                 1255                 1260             


Phe Ser  Leu His Pro His Ser  Gly Glu Leu Leu Thr  Ala Ala Pro 
    1265                 1270                 1275             


Leu Ile  Arg Ala Glu Arg Pro  His Tyr Val Leu Thr  Leu Ser Ala 
    1280                 1285                 1290             


His Asp  Gln Gly Ser Pro Pro  Arg Ser Ala Ser Leu  Gln Leu Leu 
    1295                 1300                 1305             


Val Gln  Val Leu Pro Ser Ala  Arg Leu Ala Glu Pro  Pro Pro Asp 
    1310                 1315                 1320             


Leu Ala  Glu Arg Asp Pro Ala  Ala Pro Val Pro Val  Val Leu Thr 
    1325                 1330                 1335             


Val Thr  Ala Ala Glu Gly Leu  Arg Pro Gly Ser Leu  Leu Gly Ser 
    1340                 1345                 1350             


Val Ala  Ala Pro Glu Pro Ala  Gly Val Gly Ala Leu  Thr Tyr Thr 
    1355                 1360                 1365             


Leu Val  Gly Gly Ala Asp Pro  Glu Gly Thr Phe Ala  Leu Asp Ala 
    1370                 1375                 1380             


Ala Ser  Gly Arg Leu Tyr Leu  Ala Arg Pro Leu Asp  Phe Glu Ala 
    1385                 1390                 1395             


Gly Pro  Pro Trp Arg Ala Leu  Thr Val Arg Ala Glu  Gly Pro Gly 
    1400                 1405                 1410             


Gly Ala  Gly Ala Arg Leu Leu  Arg Val Gln Val Gln  Val Gln Asp 
    1415                 1420                 1425             


Glu Asn  Glu His Ala Pro Ala  Phe Ala Arg Asp Pro  Leu Ala Leu 
    1430                 1435                 1440             


Ala Leu  Pro Glu Asn Pro Glu  Pro Gly Ala Ala Leu  Tyr Thr Phe 
    1445                 1450                 1455             


Arg Ala  Ser Asp Ala Asp Gly  Pro Gly Pro Asn Ser  Asp Val Arg 
    1460                 1465                 1470             


Tyr Arg  Leu Leu Arg Gln Glu  Pro Pro Val Pro Ala  Leu Arg Leu 
    1475                 1480                 1485             


Asp Ala  Arg Thr Gly Ala Leu  Ser Ala Pro Arg Gly  Leu Asp Arg 
    1490                 1495                 1500             


Glu Thr  Thr Pro Ala Leu Leu  Leu Leu Val Glu Ala  Thr Asp Arg 
    1505                 1510                 1515             


Pro Ala  Asn Ala Ser Arg Arg  Arg Ala Ala Arg Val  Ser Ala Arg 
    1520                 1525                 1530             


Val Phe  Val Thr Asp Glu Asn  Asp Asn Ala Pro Val  Phe Ala Ser 
    1535                 1540                 1545             


Pro Ser  Arg Val Arg Leu Pro  Glu Asp Gln Pro Pro  Gly Pro Ala 
    1550                 1555                 1560             


Ala Leu  His Val Val Ala Arg  Asp Pro Asp Leu Gly  Glu Ala Ala 
    1565                 1570                 1575             


Arg Val  Ser Tyr Arg Leu Ala  Ser Gly Gly Asp Gly  His Phe Arg 
    1580                 1585                 1590             


Leu His  Ser Ser Thr Gly Ala  Leu Ser Val Val Arg  Pro Leu Asp 
    1595                 1600                 1605             


Arg Glu  Gln Arg Ala Glu His  Val Leu Thr Val Val  Ala Ser Asp 
    1610                 1615                 1620             


His Gly  Ser Pro Pro Arg Ser  Ala Thr Gln Val Leu  Thr Val Ser 
    1625                 1630                 1635             


Val Ala  Asp Val Asn Asp Glu  Ala Pro Thr Phe Gln  Gln Gln Glu 
    1640                 1645                 1650             


Tyr Ser  Val Leu Leu Arg Glu  Asn Asn Pro Pro Gly  Thr Ser Leu 
    1655                 1660                 1665             


Leu Thr  Leu Arg Ala Thr Asp  Pro Asp Val Gly Ala  Asn Gly Gln 
    1670                 1675                 1680             


Val Thr  Tyr Gly Gly Val Ser  Ser Glu Ser Phe Ser  Leu Asp Pro 
    1685                 1690                 1695             


Asp Thr  Gly Val Leu Thr Thr  Leu Arg Ala Leu Asp  Arg Glu Glu 
    1700                 1705                 1710             


Gln Glu  Glu Ile Asn Leu Thr  Val Tyr Ala Gln Asp  Arg Gly Ser 
    1715                 1720                 1725             


Pro Pro  Gln Leu Thr His Val  Thr Val Arg Val Ala  Val Glu Asp 
    1730                 1735                 1740             


Glu Asn  Asp His Ala Pro Thr  Phe Gly Ser Ala His  Leu Ser Leu 
    1745                 1750                 1755             


Glu Val  Pro Glu Gly Gln Asp  Pro Gln Thr Leu Thr  Met Leu Arg 
    1760                 1765                 1770             


Ala Ser  Asp Pro Asp Val Gly  Ala Asn Gly Gln Leu  Gln Tyr Arg 
    1775                 1780                 1785             


Ile Leu  Asp Gly Asp Pro Ser  Gly Ala Phe Val Leu  Asp Leu Ala 
    1790                 1795                 1800             


Ser Gly  Glu Phe Gly Thr Met  Arg Pro Leu Asp Arg  Glu Val Glu 
    1805                 1810                 1815             


Pro Ala  Phe Gln Leu Arg Ile  Glu Ala Arg Asp Gly  Gly Gln Pro 
    1820                 1825                 1830             


Ala Leu  Ser Ala Thr Leu Leu  Leu Thr Val Thr Val  Leu Asp Ala 
    1835                 1840                 1845             


Asn Asp  His Ala Pro Ala Phe  Pro Val Pro Ala Tyr  Ser Val Glu 
    1850                 1855                 1860             


Val Pro  Glu Asp Val Pro Ala  Gly Thr Leu Leu Leu  Gln Leu Gln 
    1865                 1870                 1875             


Ala His  Asp Pro Asp Ala Gly  Ala Asn Gly His Val  Thr Tyr Tyr 
    1880                 1885                 1890             


Leu Gly  Ala Gly Thr Ala Gly  Ala Phe Leu Leu Glu  Pro Ser Ser 
    1895                 1900                 1905             


Gly Glu  Leu Arg Thr Ala Ala  Ala Leu Asp Arg Glu  Gln Cys Pro 
    1910                 1915                 1920             


Ser Tyr  Thr Phe Ser Val Ser  Ala Val Asp Gly Ala  Ala Ala Gly 
    1925                 1930                 1935             


Pro Leu  Ser Thr Thr Val Ser  Val Thr Ile Thr Val  Arg Asp Val 
    1940                 1945                 1950             


Asn Asp  His Ala Pro Thr Phe  Pro Thr Ser Pro Leu  Arg Leu Arg 
    1955                 1960                 1965             


Leu Pro  Arg Pro Gly Pro Ser  Phe Ser Thr Pro Thr  Leu Ala Leu 
    1970                 1975                 1980             


Ala Thr  Leu Arg Ala Glu Asp  Arg Asp Ala Gly Ala  Asn Ala Ser 
    1985                 1990                 1995             


Ile Leu  Tyr Arg Leu Ala Gly  Thr Pro Pro Pro Gly  Thr Thr Val 
    2000                 2005                 2010             


Asp Ser  Tyr Thr Gly Glu Ile  Arg Val Ala Arg Ser  Pro Val Ala 
    2015                 2020                 2025             


Leu Gly  Pro Arg Asp Arg Val  Leu Phe Ile Val Ala  Thr Asp Leu 
    2030                 2035                 2040             


Gly Arg  Pro Ala Arg Ser Ala  Thr Gly Val Ile Ile  Val Gly Leu 
    2045                 2050                 2055             


Gln Gly  Glu Ala Glu Arg Gly  Pro Arg Phe Pro Arg  Ala Ser Ser 
    2060                 2065                 2070             


Glu Ala  Thr Ile Arg Glu Asn  Ala Pro Pro Gly Thr  Pro Ile Val 
    2075                 2080                 2085             


Ser Pro  Arg Ala Val His Ala  Gly Gly Thr Asn Gly  Pro Ile Thr 
    2090                 2095                 2100             


Tyr Ser  Ile Leu Ser Gly Asn  Glu Lys Gly Thr Phe  Ser Ile Gln 
    2105                 2110                 2115             


Pro Ser  Thr Gly Ala Ile Thr  Val Arg Ser Ala Glu  Gly Leu Asp 
    2120                 2125                 2130             


Phe Glu  Val Ser Pro Arg Leu  Arg Leu Val Leu Gln  Ala Glu Ser 
    2135                 2140                 2145             


Gly Gly  Ala Phe Ala Phe Thr  Val Leu Thr Leu Thr  Leu Gln Asp 
    2150                 2155                 2160             


Ala Asn  Asp Asn Ala Pro Arg  Phe Leu Arg Pro His  Tyr Val Ala 
    2165                 2170                 2175             


Phe Leu  Pro Glu Ser Arg Pro  Leu Glu Gly Pro Leu  Leu Gln Val 
    2180                 2185                 2190             


Glu Ala  Asp Asp Leu Asp Gln  Gly Ser Gly Gly Gln  Ile Ser Tyr 
    2195                 2200                 2205             


Ser Leu  Ala Ala Ser Gln Pro  Ala Arg Gly Leu Phe  His Val Asp 
    2210                 2215                 2220             


Pro Thr  Thr Gly Thr Ile Thr  Thr Thr Ala Ile Leu  Asp Arg Glu 
    2225                 2230                 2235             


Ile Trp  Ala Glu Thr Arg Leu  Val Leu Met Ala Thr  Asp Arg Gly 
    2240                 2245                 2250             


Ser Pro  Ala Leu Val Gly Ser  Ala Thr Leu Thr Val  Met Val Ile 
    2255                 2260                 2265             


Asp Thr  Asn Asp Asn Arg Pro  Thr Ile Pro Gln Pro  Trp Glu Leu 
    2270                 2275                 2280             


Arg Val  Ser Glu Asp Ala Leu  Leu Gly Ser Glu Ile  Ala Gln Val 
    2285                 2290                 2295             


Thr Gly  Asn Asp Val Asp Ser  Gly Pro Val Leu Trp  Tyr Val Leu 
    2300                 2305                 2310             


Ser Pro  Ser Gly Pro Gln Asp  Pro Phe Ser Val Gly  Arg Tyr Gly 
    2315                 2320                 2325             


Gly Arg  Val Ser Leu Thr Gly  Pro Leu Asp Phe Glu  Gln Cys Asp 
    2330                 2335                 2340             


Arg Tyr  Gln Leu Gln Leu Leu  Ala His Asp Gly Pro  His Glu Gly 
    2345                 2350                 2355             


Arg Ala  Asn Leu Thr Val Leu  Val Glu Asp Val Asn  Asp Asn Ala 
    2360                 2365                 2370             


Pro Ala  Phe Ser Gln Ser Leu  Tyr Gln Val Met Leu  Leu Glu His 
    2375                 2380                 2385             


Thr Pro  Pro Gly Ser Ala Ile  Leu Ser Val Ser Ala  Thr Asp Arg 
    2390                 2395                 2400             


Asp Ser  Gly Ala Asn Gly His  Ile Ser Tyr His Leu  Ala Ser Pro 
    2405                 2410                 2415             


Ala Asp  Gly Phe Ser Val Asp  Pro Asn Asn Gly Thr  Leu Phe Thr 
    2420                 2425                 2430             


Ile Val  Gly Thr Val Ala Leu  Gly His Asp Gly Ser  Gly Ala Val 
    2435                 2440                 2445             


Asp Val  Val Leu Glu Ala Arg  Asp His Gly Ala Pro  Gly Arg Ala 
    2450                 2455                 2460             


Ala Arg  Ala Thr Val His Val  Gln Leu Gln Asp Gln  Asn Asp His 
    2465                 2470                 2475             


Ala Pro  Ser Phe Thr Leu Ser  His Tyr Arg Val Ala  Val Thr Glu 
    2480                 2485                 2490             


Asp Leu  Pro Pro Gly Ser Thr  Leu Leu Thr Leu Glu  Ala Thr Asp 
    2495                 2500                 2505             


Ala Asp  Gly Ser Arg Ser His  Ala Ala Val Asp Tyr  Ser Ile Ile 
    2510                 2515                 2520             


Ser Gly  Asn Trp Gly Arg Val  Phe Gln Leu Glu Pro  Arg Leu Ala 
    2525                 2530                 2535             


Glu Ala  Gly Glu Ser Ala Gly  Pro Gly Pro Arg Ala  Leu Gly Cys 
    2540                 2545                 2550             


Leu Val  Leu Leu Glu Pro Leu  Asp Phe Glu Ser Leu  Thr Gln Tyr 
    2555                 2560                 2565             


Asn Leu  Thr Val Ala Ala Ala  Asp Arg Gly Gln Pro  Pro Gln Ser 
    2570                 2575                 2580             


Ser Val  Val Pro Val Thr Val  Thr Val Leu Asp Val  Asn Asp Asn 
    2585                 2590                 2595             


Pro Pro  Val Phe Thr Arg Ala  Ser Tyr Arg Val Thr  Val Pro Glu 
    2600                 2605                 2610             


Asp Thr  Pro Val Gly Ala Glu  Leu Leu His Val Glu  Ala Ser Asp 
    2615                 2620                 2625             


Ala Asp  Pro Gly Pro His Gly  Leu Val Arg Phe Thr  Val Ser Ser 
    2630                 2635                 2640             


Gly Asp  Pro Ser Gly Leu Phe  Glu Leu Asp Glu Ser  Ser Gly Thr 
    2645                 2650                 2655             


Leu Arg  Leu Ala His Ala Leu  Asp Cys Glu Thr Gln  Ala Arg His 
    2660                 2665                 2670             


Gln Leu  Val Val Gln Ala Ala  Asp Pro Ala Gly Ala  His Phe Ala 
    2675                 2680                 2685             


Leu Ala  Pro Val Thr Ile Glu  Val Gln Asp Val Asn  Asp His Gly 
    2690                 2695                 2700             


Pro Ala  Phe Pro Leu Asn Leu  Leu Ser Thr Ser Val  Ala Glu Asn 
    2705                 2710                 2715             


Gln Pro  Pro Gly Thr Leu Val  Thr Thr Leu His Ala  Ile Asp Gly 
    2720                 2725                 2730             


Asp Ala  Gly Ala Phe Gly Arg  Leu Arg Tyr Ser Leu  Leu Glu Ala 
    2735                 2740                 2745             


Gly Pro  Gly Pro Glu Gly Arg  Glu Ala Phe Ala Leu  Asn Ser Ser 
    2750                 2755                 2760             


Thr Gly  Glu Leu Arg Ala Arg  Val Pro Phe Asp Tyr  Glu His Thr 
    2765                 2770                 2775             


Glu Ser  Phe Arg Leu Leu Val  Gly Ala Ala Asp Ala  Gly Asn Leu 
    2780                 2785                 2790             


Ser Ala  Ser Val Thr Val Ser  Val Leu Val Thr Gly  Glu Asp Glu 
    2795                 2800                 2805             


Tyr Asp  Pro Val Phe Leu Ala  Pro Ala Phe His Phe  Gln Val Pro 
    2810                 2815                 2820             


Glu Gly  Ala Arg Arg Gly His  Ser Leu Gly His Val  Gln Ala Thr 
    2825                 2830                 2835             


Asp Glu  Asp Gly Gly Ala Asp  Gly Leu Val Leu Tyr  Ser Leu Ala 
    2840                 2845                 2850             


Thr Ser  Ser Pro Tyr Phe Gly  Ile Asn Gln Thr Thr  Gly Ala Leu 
    2855                 2860                 2865             


Tyr Leu  Arg Val Asp Ser Arg  Ala Pro Gly Ser Gly  Thr Ala Thr 
    2870                 2875                 2880             


Ser Gly  Gly Gly Gly Arg Thr  Arg Arg Glu Ala Pro  Arg Glu Leu 
    2885                 2890                 2895             


Arg Leu  Glu Val Ile Ala Arg  Gly Pro Leu Pro Gly  Ser Arg Ser 
    2900                 2905                 2910             


Ala Thr  Val Pro Val Thr Val  Asp Ile Thr His Thr  Ala Leu Gly 
    2915                 2920                 2925             


Leu Ala  Pro Asp Leu Asn Leu  Leu Leu Val Gly Ala  Val Ala Ala 
    2930                 2935                 2940             


Ser Leu  Gly Val Val Val Val  Leu Ala Leu Ala Ala  Leu Val Leu 
    2945                 2950                 2955             


Gly Leu  Val Arg Ala Arg Ser  Arg Lys Ala Glu Ala  Ala Pro Gly 
    2960                 2965                 2970             


Pro Met  Ser Gln Ala Ala Pro  Leu Ala Ser Asp Ser  Leu Gln Lys 
    2975                 2980                 2985             


Leu Gly  Arg Glu Pro Pro Ser  Pro Pro Pro Ser Glu  His Leu Tyr 
    2990                 2995                 3000             


His Gln  Thr Leu Pro Ser Tyr  Gly Gly Pro Gly Ala  Gly Gly Pro 
    3005                 3010                 3015             


Tyr Pro  Arg Gly Gly Ser Leu  Asp Pro Ser His Ser  Ser Gly Arg 
    3020                 3025                 3030             


Gly Ser  Ala Glu Ala Ala Glu  Asp Asp Glu Ile Arg  Met Ile Asn 
    3035                 3040                 3045             


Glu Phe  Pro Arg Val Ala Ser  Val Ala Ser Ser Leu  Ala Ala Arg 
    3050                 3055                 3060             


Gly Pro  Asp Ser Gly Ile Gln  Gln Asp Ala Asp Gly  Leu Ser Asp 
    3065                 3070                 3075             


Thr Ser  Cys Glu Pro Pro Ala  Pro Asp Thr Trp Tyr  Lys Gly Arg 
    3080                 3085                 3090             


Lys Ala  Gly Leu Leu Leu Pro  Gly Ala Gly Ala Thr  Leu Tyr Arg 
    3095                 3100                 3105             


Glu Glu  Gly Pro Pro Ala Thr  Ala Thr Ala Phe Leu  Gly Gly Cys 
    3110                 3115                 3120             


Gly Leu  Ser Pro Ala Pro Thr  Gly Asp Tyr Gly Phe  Pro Ala Asp 
    3125                 3130                 3135             


Gly Lys  Pro Cys Val Ala Gly  Ala Leu Thr Ala Ile  Val Ala Gly 
    3140                 3145                 3150             


Glu Glu  Glu Leu Arg Gly Ser  Tyr Asn Trp Asp Tyr  Leu Leu Ser 
    3155                 3160                 3165             


Trp Cys  Pro Gln Phe Gln Pro  Leu Ala Ser Val Phe  Thr Glu Ile 
    3170                 3175                 3180             


Ala Arg  Leu Lys Asp Glu Ala  Arg Pro Cys Pro Pro  Ala Pro Arg 
    3185                 3190                 3195             


Ile Asp  Pro Pro Pro Leu Ile  Thr Ala Val Ala His  Pro Gly Ala 
    3200                 3205                 3210             


Lys Ser  Val Pro Pro Lys Pro  Ala Asn Thr Ala Ala  Ala Arg Ala 
    3215                 3220                 3225             


Ile Phe  Pro Pro Ala Ser His  Arg Ser Pro Ile Ser  His Glu Gly 
    3230                 3235                 3240             


Ser Leu  Ser Ser Ala Ala Met  Ser Pro Ser Phe Ser  Pro Ser Leu 
    3245                 3250                 3255             


Ser Pro  Leu Ala Ala Arg Ser  Pro Val Val Ser Pro  Phe Gly Val 
    3260                 3265                 3270             


Ala Gln  Gly Pro Ser Ala Ser  Ala Leu Ser Ala Glu  Ser Gly Leu 
    3275                 3280                 3285             


Glu Pro  Pro Asp Asp Thr Glu  Leu His Ile 
    3290                 3295             


<210>  2910
<211>  1369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCHS2__Homo_sapiens__NP_001136024

<400>  2910

Met Ser Pro Cys Gly Arg Lys Met Gly Glu Gly Arg Gln Gln Arg Arg 
1               5                   10                  15      


Ala Pro Val Gly Lys Leu Leu Leu Leu Pro Gly Arg Arg Asp Thr Pro 
            20                  25                  30          


His Gly Arg Ser Gly Ser Ser Gly Ala Arg Thr Gln Arg Ser Leu Leu 
        35                  40                  45              


Trp Leu Leu Val His Val Trp Leu Trp Ala Ala Ser Gly Ser Ser Ala 
    50                  55                  60                  


Gln Leu Phe Asn Leu Thr Leu Ser Val Asp Glu Gly Leu Pro Pro Asp 
65                  70                  75                  80  


Thr Leu Val Gly Asp Ile Arg Ala Gly Leu Pro Ala Ala Gln Gln Gln 
                85                  90                  95      


Glu Gly Ser Gly Phe Phe Leu Ser Glu Asp Ser Asp Asp Ser Pro Leu 
            100                 105                 110         


Leu Asp Asp Phe His Val His Pro Asp Thr Gly Ile Ile Arg Thr Ala 
        115                 120                 125             


Arg Arg Leu Asp Arg Glu Arg Arg Asp His Tyr Ser Phe Val Ala Ala 
    130                 135                 140                 


Thr Leu Leu Gly Ala Val Val Gln Val Glu Ile Arg Val Asn Asp Val 
145                 150                 155                 160 


Asn Asp His Ser Pro Arg Phe Pro Leu Asp Ser Leu Gln Leu Asp Val 
                165                 170                 175     


Ser Glu Leu Ser Pro Pro Gly Thr Ala Phe Arg Leu Pro Val Ala His 
            180                 185                 190         


Asp Pro Asp Ala Gly Leu Phe Ser Thr Gln Gly Tyr Thr Leu Val Gln 
        195                 200                 205             


Pro Ser Asp Leu Pro Lys Asp Pro Ala Gly Pro Phe Phe Gln Leu Arg 
    210                 215                 220                 


Tyr Arg Thr Pro Gly Pro Leu Pro Ser Pro Leu Leu Pro Gly Ser Ser 
225                 230                 235                 240 


Ser Pro Leu Glu Pro Leu Asp Leu Val Leu Leu Arg Arg Leu Asp Arg 
                245                 250                 255     


Glu Glu Ala Ala Ala His Arg Leu Gln Ile Glu Ala Trp Asp Gly Gly 
            260                 265                 270         


Arg Pro Arg Arg Thr Gly Leu Leu Ser Val Glu Leu Arg Val Leu Asp 
        275                 280                 285             


Glu Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Tyr Arg Ala Ala 
    290                 295                 300                 


Val Arg Glu Asp Ala Gln Pro Gly Ala Glu Val Cys Arg Val Arg Ala 
305                 310                 315                 320 


Thr Asp Arg Asp Leu Gly Pro Asn Gly Phe Val Arg Tyr Ser Val Arg 
                325                 330                 335     


Ala Arg Gln Val Pro Gly Ala Gly Ser Gly Gly Gly Ala Leu Gly Asp 
            340                 345                 350         


Ala Ala Tyr Phe Ala Val Glu Glu Leu Ser Gly Val Val Arg Val Trp 
        355                 360                 365             


Arg Pro Leu Asp Arg Glu Ala Gln Ala Trp His Gln Leu Val Val Glu 
    370                 375                 380                 


Ala Arg Asp Gly Gly Ala Glu Pro Glu Val Ala Thr Val Arg Val Ser 
385                 390                 395                 400 


Ile Ala Val Leu Asp Val Asn Asp Asn Arg Pro Ala Ile His Val Leu 
                405                 410                 415     


Phe Leu Thr Glu Gly Gly Val Ala Arg Val Ser Glu Gly Ala Arg Pro 
            420                 425                 430         


Gly Asp Tyr Val Ala Arg Val Ser Val Ser Asp Ala Asp Gly Asp Trp 
        435                 440                 445             


Glu Lys Glu Asp Glu Ala Thr Gly Glu Leu Gly Val Gly Leu Gly Asp 
    450                 455                 460                 


Gly Ser Ile Ser Leu Ser Leu Glu Gly Gly Glu Gly Asp Phe Ala Leu 
465                 470                 475                 480 


Leu Pro Gly Gly Pro Pro Gly Val Phe Phe Leu Cys Val Glu Gly Pro 
                485                 490                 495     


Leu Asp Arg Glu Ser Arg Asp Leu Tyr Glu Leu Leu Leu Val Ala Thr 
            500                 505                 510         


Asp Ala Gly Ser Pro Pro Leu Ser Thr Glu Glu Thr Leu Leu Leu Arg 
        515                 520                 525             


Val Ala Asp Leu Asn Asp Gln Pro Pro Leu Phe Ser Gln Gln His Tyr 
    530                 535                 540                 


Lys Ala Ser Val Ser Glu Ala Ala Ala Pro Gly Thr Val Val Met Trp 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Glu Ala Gly Ser Asp His Ala Trp Leu 
                565                 570                 575     


Arg Tyr Thr Val Val Gln Leu Ser Ala Pro Cys Asn Leu Gly Ser Leu 
            580                 585                 590         


Gln Ser Lys Met Val His Thr Ala Glu Cys Gly Pro Ser Phe Ala Ile 
        595                 600                 605             


Asp Ser Glu Ser Gly Ala Ile Ser Thr Ile Arg Thr Leu Asp Arg Glu 
    610                 615                 620                 


Val Gln Glu Ala Val Glu Leu Lys Val Val Ala Gln Asp Leu Gly Glu 
625                 630                 635                 640 


Pro Pro Leu Ser Ala Thr Cys Leu Val Ser Ile Thr Val Asp Asp Val 
                645                 650                 655     


Asn Asp Asn Glu Pro Ile Phe Trp Arg Gln Val Tyr Asn Ala Thr Ile 
            660                 665                 670         


Ala Glu His Ala Pro Val Gly His Cys Phe Leu Gln Val Thr Ala Ser 
        675                 680                 685             


Asp Ala Asp Ser Gly Leu Tyr Gly Phe Ile Glu Tyr Ser Leu Tyr Asp 
    690                 695                 700                 


Gly Phe Leu Ser Tyr Glu Ala Pro Gln Ala Phe Arg Ile Asp Pro His 
705                 710                 715                 720 


Asp Gly Gln Ile Cys Val Ser Gln Asp Ile Asp Arg Glu Arg Asp Pro 
                725                 730                 735     


Ala Thr Tyr Asp Leu Leu Val Glu Ala Lys Asp Gly Gly Gly Leu Ser 
            740                 745                 750         


Ala Gln Ala Phe Val Arg Val Asp Leu Glu Asp Val Asn Asp Asn His 
        755                 760                 765             


Pro Val Phe Asn Pro Ser Thr Tyr Val Thr Ser Ile Ser Asp Glu Thr 
    770                 775                 780                 


Gln Pro Gly Thr Glu Ile Ile Asn Val Leu Ala Thr Asp Gln Asp Ser 
785                 790                 795                 800 


Gly Ile Tyr Gly Thr Val Ala Tyr Glu Leu Ile Pro Gly Asn Val Ser 
                805                 810                 815     


Ser Leu Phe Thr Ile Asp Ser Thr Thr Gly Ile Ile Tyr Leu Thr Leu 
            820                 825                 830         


Pro Leu Ser His Leu Glu Ser Thr Thr Leu Ser Leu Met Val Ser Ala 
        835                 840                 845             


Gln Asp Gly Gly Gly Leu Thr Ala Val Ile Asn Ala Asp Val Thr Ile 
    850                 855                 860                 


His Ile Phe Gln Thr Thr Leu Ala Pro Ala Glu Phe Glu Arg Pro Lys 
865                 870                 875                 880 


Tyr Thr Phe Leu Val Tyr Glu Asp Val Pro Glu Asp Ser Pro Ile Gly 
                885                 890                 895     


Thr Val Lys Ala Arg Glu Pro Leu Asn Ser Ser Glu Pro Ile Phe Tyr 
            900                 905                 910         


Arg Ile Ser Ser Gly Asp Leu Gly Gly Lys Phe Ser Ile His Pro Arg 
        915                 920                 925             


Leu Gly Thr Ile Arg Thr Arg Lys Pro Leu Asp His Glu Thr Gln Pro 
    930                 935                 940                 


Val Val Val Leu Thr Val Gln Ala Gln Leu Gly Ser Ala Pro Ala Cys 
945                 950                 955                 960 


Ser Ser Thr Glu Val Asn Ile Thr Val Met Asp Val Asn Asp Asn His 
                965                 970                 975     


Pro Ala Phe Leu Arg Thr Ser Asp Glu Ile Arg Ile Ser Gln Thr Thr 
            980                 985                 990         


Pro Pro Gly Thr Ala Leu Tyr Leu  Ala Arg Ala Glu Asp  Arg Asp Ser 
        995                 1000                 1005             


Gly Arg  Asn Gly Leu Ile Arg  Tyr Ser Ile Ala Ser  Pro Gln Pro 
    1010                 1015                 1020             


Gly Val  Phe Ala Ile Asp Arg  Ala Leu Gly Val Leu  Phe Leu Asn 
    1025                 1030                 1035             


Gly Ser  Leu Gly Ala Gly Glu  Gln Arg Glu Leu Thr  Leu Thr Leu 
    1040                 1045                 1050             


Arg Ala  Glu Asp Gln Gly Val  His Pro Gln Ala Ala  Leu Leu Val 
    1055                 1060                 1065             


Leu Thr  Val Val Ile Glu Lys  Arg Glu His Ser Pro  Ser Trp Thr 
    1070                 1075                 1080             


Phe Glu  His Leu Val Tyr Gln  Val Glu Val Ser Glu  Ser Leu Ser 
    1085                 1090                 1095             


Pro Met  Thr Gln Met Leu Gln  Thr Gln Ala His Pro  Leu Gly Pro 
    1100                 1105                 1110             


Gln Arg  Ala Ala Ser Pro Leu  Arg Tyr Ser Leu Glu  Pro Ser Val 
    1115                 1120                 1125             


Asp Ser  Ala Met Phe Gly Ile  Arg Pro Tyr Thr Gly  Trp Ile Tyr 
    1130                 1135                 1140             


Leu Arg  Arg Gln Phe Asp Tyr  Glu Ser Thr Gln Thr  Tyr Asn Phe 
    1145                 1150                 1155             


Arg Val  Phe Ala Trp Ile Pro  Glu Asp Gly Phe Leu  Gln Asn Val 
    1160                 1165                 1170             


Ser Thr  Thr Val Ile Val Arg  Val Trp Asp Glu Asn  Asp Asn Ser 
    1175                 1180                 1185             


Pro Thr  Phe Leu His Asp Val  Leu Phe Leu Lys Val  Glu Glu Ser 
    1190                 1195                 1200             


Pro Val  Pro Gln Gly Val Ile  Gly Lys Ile Thr Ala  Ile Asp Met 
    1205                 1210                 1215             


Asp Ser  Gly Lys Asn Gly Gln  Leu Leu Tyr Phe Leu  Leu Ser Asp 
    1220                 1225                 1230             


Gly Lys  Phe Phe Lys Met Asn  Pro Asn Thr Gly Glu  Leu Ile Asn 
    1235                 1240                 1245             


Trp Val  Ala Leu Asp Arg Glu  His Arg Gly His His  Glu Met Thr 
    1250                 1255                 1260             


Val Leu  Val Thr Asp Arg Gly  Ser Pro Pro Arg Asn  Ala Thr Met 
    1265                 1270                 1275             


Ala Val  Tyr Val Ser Val Thr  Asp Ile Asn Asp Asn  Arg Pro Phe 
    1280                 1285                 1290             


Phe Pro  Gln Cys Leu Pro Gly  Lys Glu Leu His Val  Lys Val Leu 
    1295                 1300                 1305             


Glu Gly  Gln Pro Val Asn Met  Leu Val Thr Thr Val  Phe Ala Lys 
    1310                 1315                 1320             


Asp Pro  Asp Glu Gly Asn Asn  Ala Glu Val Thr Tyr  Ser Val Ser 
    1325                 1330                 1335             


Ser Ala  Arg Pro Met Pro Leu  Lys Gly Lys Thr Ala  Phe Gly Lys 
    1340                 1345                 1350             


Gln Ser  Cys Lys Lys Gln Thr  Asn Lys Gln Thr Asn  Lys Ile Leu 
    1355                 1360                 1365             


Thr 
    


<210>  2911
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCK__Homo_sapiens__NP_000779

<400>  2911

Met Ala Thr Pro Pro Lys Arg Ser Cys Pro Ser Phe Ser Ala Ser Ser 
1               5                   10                  15      


Glu Gly Thr Arg Ile Lys Lys Ile Ser Ile Glu Gly Asn Ile Ala Ala 
            20                  25                  30          


Gly Lys Ser Thr Phe Val Asn Ile Leu Lys Gln Leu Cys Glu Asp Trp 
        35                  40                  45              


Glu Val Val Pro Glu Pro Val Ala Arg Trp Cys Asn Val Gln Ser Thr 
    50                  55                  60                  


Gln Asp Glu Phe Glu Glu Leu Thr Met Ser Gln Lys Asn Gly Gly Asn 
65                  70                  75                  80  


Val Leu Gln Met Met Tyr Glu Lys Pro Glu Arg Trp Ser Phe Thr Phe 
                85                  90                  95      


Gln Thr Tyr Ala Cys Leu Ser Arg Ile Arg Ala Gln Leu Ala Ser Leu 
            100                 105                 110         


Asn Gly Lys Leu Lys Asp Ala Glu Lys Pro Val Leu Phe Phe Glu Arg 
        115                 120                 125             


Ser Val Tyr Ser Asp Arg Tyr Ile Phe Ala Ser Asn Leu Tyr Glu Ser 
    130                 135                 140                 


Glu Cys Met Asn Glu Thr Glu Trp Thr Ile Tyr Gln Asp Trp His Asp 
145                 150                 155                 160 


Trp Met Asn Asn Gln Phe Gly Gln Ser Leu Glu Leu Asp Gly Ile Ile 
                165                 170                 175     


Tyr Leu Gln Ala Thr Pro Glu Thr Cys Leu His Arg Ile Tyr Leu Arg 
            180                 185                 190         


Gly Arg Asn Glu Glu Gln Gly Ile Pro Leu Glu Tyr Leu Glu Lys Leu 
        195                 200                 205             


His Tyr Lys His Glu Ser Trp Leu Leu His Arg Thr Leu Lys Thr Asn 
    210                 215                 220                 


Phe Asp Tyr Leu Gln Glu Val Pro Ile Leu Thr Leu Asp Val Asn Glu 
225                 230                 235                 240 


Asp Phe Lys Asp Lys Tyr Glu Ser Leu Val Glu Lys Val Lys Glu Phe 
                245                 250                 255     


Leu Ser Thr Leu 
            260 


<210>  2912
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCLK1__Homo_sapiens__NP_001182344

<400>  2912

Met Leu Glu Leu Ile Glu Val Asn Gly Thr Pro Gly Ser Gln Leu Ser 
1               5                   10                  15      


Thr Pro Arg Ser Gly Lys Ser Pro Ser Pro Ser Pro Thr Ser Pro Gly 
            20                  25                  30          


Ser Leu Arg Lys Gln Arg Ser Ser Gln His Gly Gly Ser Ser Thr Ser 
        35                  40                  45              


Leu Ala Ser Thr Lys Val Cys Ser Ser Met Asp Glu Asn Asp Gly Pro 
    50                  55                  60                  


Gly Glu Glu Val Ser Glu Glu Gly Phe Gln Ile Pro Ala Thr Ile Thr 
65                  70                  75                  80  


Glu Arg Tyr Lys Val Gly Arg Thr Ile Gly Asp Gly Asn Phe Ala Val 
                85                  90                  95      


Val Lys Glu Cys Val Glu Arg Ser Thr Ala Arg Glu Tyr Ala Leu Lys 
            100                 105                 110         


Ile Ile Lys Lys Ser Lys Cys Arg Gly Lys Glu His Met Ile Gln Asn 
        115                 120                 125             


Glu Val Ser Ile Leu Arg Arg Val Lys His Pro Asn Ile Val Leu Leu 
    130                 135                 140                 


Ile Glu Glu Met Asp Val Pro Thr Glu Leu Tyr Leu Val Met Glu Leu 
145                 150                 155                 160 


Val Lys Gly Gly Asp Leu Phe Asp Ala Ile Thr Ser Thr Asn Lys Tyr 
                165                 170                 175     


Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr Asn Leu Ala Ser Ala Ile 
            180                 185                 190         


Lys Tyr Leu His Ser Leu Asn Ile Val His Arg Asp Ile Lys Pro Glu 
        195                 200                 205             


Asn Leu Leu Val Tyr Glu His Gln Asp Gly Ser Lys Ser Leu Lys Leu 
    210                 215                 220                 


Gly Asp Phe Gly Leu Ala Thr Ile Val Asp Gly Pro Leu Tyr Thr Val 
225                 230                 235                 240 


Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Ile Ala Glu Thr Gly 
                245                 250                 255     


Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala Gly Val Ile Thr Tyr Ile 
            260                 265                 270         


Leu Leu Cys Gly Phe Pro Pro Phe Arg Gly Ser Gly Asp Asp Gln Glu 
        275                 280                 285             


Val Leu Phe Asp Gln Ile Leu Met Gly Gln Val Asp Phe Pro Ser Pro 
    290                 295                 300                 


Tyr Trp Asp Asn Val Ser Asp Ser Ala Lys Glu Leu Ile Thr Met Met 
305                 310                 315                 320 


Leu Leu Val Asp Val Asp Gln Arg Phe Ser Ala Val Gln Val Leu Glu 
                325                 330                 335     


His Pro Trp Val Asn Asp Asp Gly Leu Pro Glu Asn Glu His Gln Leu 
            340                 345                 350         


Ser Val Ala Gly Lys Ile Lys Lys His Phe Asn Thr Gly Pro Lys Pro 
        355                 360                 365             


Asn Ser Thr Ala Ala Gly Val Ser Val Ile Ala Leu Asp His Gly Phe 
    370                 375                 380                 


Thr Ile Lys Arg Ser Gly Ser Leu Asp Tyr Tyr Gln Gln Pro Gly Met 
385                 390                 395                 400 


Tyr Trp Ile Arg Pro Pro Leu Leu Ile Arg Arg Gly Arg Phe Ser Asp 
                405                 410                 415     


Glu Asp Ala Thr Arg Met 
            420         


<210>  2913
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCLK2__Homo_sapiens__NP_001035350

<400>  2913

Met Ala Ser Thr Arg Ser Ile Glu Leu Glu His Phe Glu Glu Arg Asp 
1               5                   10                  15      


Lys Arg Pro Arg Pro Gly Ser Arg Arg Gly Ala Pro Ser Ser Ser Gly 
            20                  25                  30          


Gly Ser Ser Ser Ser Gly Pro Lys Gly Asn Gly Leu Ile Pro Ser Pro 
        35                  40                  45              


Ala His Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala 
    50                  55                  60                  


Leu Ser Ser Glu Lys Lys Ala Lys Lys Ala Arg Phe Tyr Arg Asn Gly 
65                  70                  75                  80  


Asp Arg Tyr Phe Lys Gly Leu Val Phe Ala Ile Ser Ser Asp Arg Phe 
                85                  90                  95      


Arg Ser Phe Asp Ala Leu Leu Ile Glu Leu Thr Arg Ser Leu Ser Asp 
            100                 105                 110         


Asn Val Asn Leu Pro Gln Gly Val Arg Thr Ile Tyr Thr Ile Asp Gly 
        115                 120                 125             


Ser Arg Lys Val Thr Ser Leu Asp Glu Leu Leu Glu Gly Glu Ser Tyr 
    130                 135                 140                 


Val Cys Ala Ser Asn Glu Pro Phe Arg Lys Val Asp Tyr Thr Lys Asn 
145                 150                 155                 160 


Ile Asn Pro Asn Trp Ser Val Asn Ile Lys Gly Gly Thr Ser Arg Ala 
                165                 170                 175     


Leu Ala Ala Ala Ser Ser Val Lys Ser Glu Val Lys Glu Ser Lys Asp 
            180                 185                 190         


Phe Ile Lys Pro Lys Leu Val Thr Val Ile Arg Ser Gly Val Lys Pro 
        195                 200                 205             


Arg Lys Ala Val Arg Ile Leu Leu Asn Lys Lys Thr Ala His Ser Phe 
    210                 215                 220                 


Glu Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Asp Ser Gly 
225                 230                 235                 240 


Val Val Lys Arg Leu Cys Thr Leu Asp Gly Lys Gln Val Thr Cys Leu 
                245                 250                 255     


Gln Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu 
            260                 265                 270         


Lys Phe Arg Tyr Ala Gln Asp Asp Phe Val Leu Asp His Ser Glu Cys 
        275                 280                 285             


Arg Val Leu Lys Ser Ser Tyr Ser Arg Ser Ser Ala Val Lys Tyr Ser 
    290                 295                 300                 


Gly Ser Lys Ser Pro Gly Pro Ser Arg Arg Ser Lys Ser Pro Ala Ser 
305                 310                 315                 320 


Val Asn Gly Thr Pro Ser Ser Gln Leu Ser Thr Pro Lys Ser Thr Lys 
                325                 330                 335     


Ser Ser Ser Ser Ser Pro Thr Ser Pro Gly Ser Phe Arg Gly Leu Lys 
            340                 345                 350         


Gln Ile Ser Ala His Gly Arg Ser Ser Ser Asn Val Asn Gly Gly Pro 
        355                 360                 365             


Glu Leu Asp Arg Cys Ile Ser Pro Glu Gly Val Asn Gly Asn Arg Cys 
    370                 375                 380                 


Ser Glu Ser Ser Thr Leu Leu Glu Lys Tyr Lys Ile Gly Lys Val Ile 
385                 390                 395                 400 


Gly Asp Gly Asn Phe Ala Val Val Lys Glu Cys Ile Asp Arg Ser Thr 
                405                 410                 415     


Gly Lys Glu Phe Ala Leu Lys Ile Ile Asp Lys Ala Lys Cys Cys Gly 
            420                 425                 430         


Lys Glu His Leu Ile Glu Asn Glu Val Ser Ile Leu Arg Arg Val Lys 
        435                 440                 445             


His Pro Asn Ile Ile Met Leu Val Glu Glu Met Glu Thr Ala Thr Glu 
    450                 455                 460                 


Leu Phe Leu Val Met Glu Leu Val Lys Gly Gly Asp Leu Phe Asp Ala 
465                 470                 475                 480 


Ile Thr Ser Ser Thr Lys Tyr Thr Glu Arg Asp Gly Ser Ala Met Val 
                485                 490                 495     


Tyr Asn Leu Ala Asn Ala Leu Arg Tyr Leu His Gly Leu Ser Ile Val 
            500                 505                 510         


His Arg Asp Ile Lys Pro Glu Asn Leu Leu Val Cys Glu Tyr Pro Asp 
        515                 520                 525             


Gly Thr Lys Ser Leu Lys Leu Gly Asp Phe Gly Leu Ala Thr Val Val 
    530                 535                 540                 


Glu Gly Pro Leu Tyr Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro 
545                 550                 555                 560 


Glu Ile Ile Ala Glu Thr Gly Tyr Gly Leu Lys Val Asp Ile Trp Ala 
                565                 570                 575     


Ala Gly Val Ile Thr Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg 
            580                 585                 590         


Ser Glu Asn Asn Leu Gln Glu Asp Leu Phe Asp Gln Ile Leu Ala Gly 
        595                 600                 605             


Lys Leu Glu Phe Pro Ala Pro Tyr Trp Asp Asn Ile Thr Asp Ser Ala 
    610                 615                 620                 


Lys Glu Leu Ile Ser Gln Met Leu Gln Val Asn Val Glu Ala Arg Cys 
625                 630                 635                 640 


Thr Ala Gly Gln Ile Leu Ser His Pro Trp Val Ser Asp Asp Ala Ser 
                645                 650                 655     


Gln Glu Asn Asn Met Gln Ala Glu Val Thr Gly Lys Leu Lys Gln His 
            660                 665                 670         


Phe Asn Asn Ala Leu Pro Lys Gln Asn Ser Thr Thr Thr Gly Val Ser 
        675                 680                 685             


Val Ile Met Asn Thr Ala Leu Asp Lys Glu Gly Gln Ile Phe Cys Ser 
    690                 695                 700                 


Lys His Cys Gln Asp Ser Gly Arg Pro Gly Met Glu Pro Ile Ser Pro 
705                 710                 715                 720 


Val Pro Pro Ser Val Glu Glu Ile Pro Val Pro Gly Glu Ala Val Pro 
                725                 730                 735     


Ala Pro Thr Pro Pro Glu Ser Pro Thr Pro His Pro Pro Pro Ala Ala 
            740                 745                 750         


Pro Gly Gly Glu Arg Ala Gly Thr Trp Arg Arg His Arg Asp 
        755                 760                 765     


<210>  2914
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCLK3__Homo_sapiens__NP_208382

<400>  2914

Met Gly Lys Glu Pro Leu Thr Leu Lys Ser Ile Gln Val Ala Val Glu 
1               5                   10                  15      


Glu Leu Tyr Pro Asn Lys Ala Arg Ala Leu Thr Leu Ala Gln His Ser 
            20                  25                  30          


Arg Ala Pro Ser Pro Arg Leu Arg Ser Arg Leu Phe Ser Lys Ala Leu 
        35                  40                  45              


Lys Gly Asp His Arg Cys Gly Glu Thr Glu Thr Pro Lys Ser Cys Ser 
    50                  55                  60                  


Glu Val Ala Gly Cys Lys Ala Ala Met Arg His Gln Gly Lys Ile Pro 
65                  70                  75                  80  


Glu Glu Leu Ser Leu Asp Asp Arg Ala Arg Thr Gln Lys Lys Trp Gly 
                85                  90                  95      


Arg Gly Lys Trp Glu Pro Glu Pro Ser Ser Lys Pro Pro Arg Glu Ala 
            100                 105                 110         


Thr Leu Glu Glu Arg His Ala Arg Gly Glu Lys His Leu Gly Val Glu 
        115                 120                 125             


Ile Glu Lys Thr Ser Gly Glu Ile Ile Arg Cys Glu Lys Cys Lys Arg 
    130                 135                 140                 


Glu Arg Glu Leu Gln Gln Ser Leu Glu Arg Glu Arg Leu Ser Leu Gly 
145                 150                 155                 160 


Thr Ser Glu Leu Asp Met Gly Lys Gly Pro Met Tyr Asp Val Glu Lys 
                165                 170                 175     


Leu Val Arg Thr Arg Ser Cys Arg Arg Ser Pro Glu Ala Asn Pro Ala 
            180                 185                 190         


Ser Gly Glu Glu Gly Trp Lys Gly Asp Ser His Arg Ser Ser Pro Arg 
        195                 200                 205             


Asn Pro Thr Gln Glu Leu Arg Arg Pro Ser Lys Ser Met Asp Lys Lys 
    210                 215                 220                 


Glu Asp Arg Gly Pro Glu Asp Gln Glu Ser His Ala Gln Gly Ala Ala 
225                 230                 235                 240 


Lys Ala Lys Lys Asp Leu Val Glu Val Leu Pro Val Thr Glu Glu Gly 
                245                 250                 255     


Leu Arg Glu Val Lys Lys Asp Thr Arg Pro Met Ser Arg Ser Lys His 
            260                 265                 270         


Gly Gly Trp Leu Leu Arg Glu His Gln Ala Gly Phe Glu Lys Leu Arg 
        275                 280                 285             


Arg Thr Arg Gly Glu Glu Lys Glu Ala Glu Lys Glu Lys Lys Pro Cys 
    290                 295                 300                 


Met Ser Gly Gly Arg Arg Met Thr Leu Arg Asp Asp Gln Pro Ala Lys 
305                 310                 315                 320 


Leu Glu Lys Glu Pro Lys Thr Arg Pro Glu Glu Asn Lys Pro Glu Arg 
                325                 330                 335     


Pro Ser Gly Arg Lys Pro Arg Pro Met Gly Ile Ile Ala Ala Asn Val 
            340                 345                 350         


Glu Lys His Tyr Glu Thr Gly Arg Val Ile Gly Asp Gly Asn Phe Ala 
        355                 360                 365             


Val Val Lys Glu Cys Arg His Arg Glu Thr Arg Gln Ala Tyr Ala Met 
    370                 375                 380                 


Lys Ile Ile Asp Lys Ser Arg Leu Lys Gly Lys Glu Asp Met Val Asp 
385                 390                 395                 400 


Ser Glu Ile Leu Ile Ile Gln Ser Leu Ser His Pro Asn Ile Val Lys 
                405                 410                 415     


Leu His Glu Val Tyr Glu Thr Asp Met Glu Ile Tyr Leu Ile Leu Glu 
            420                 425                 430         


Tyr Val Gln Gly Gly Asp Leu Phe Asp Ala Ile Ile Glu Ser Val Lys 
        435                 440                 445             


Phe Pro Glu Pro Asp Ala Ala Leu Met Ile Met Asp Leu Cys Lys Ala 
    450                 455                 460                 


Leu Val His Met His Asp Lys Ser Ile Val His Arg Asp Leu Lys Pro 
465                 470                 475                 480 


Glu Asn Leu Leu Val Gln Arg Asn Glu Asp Lys Ser Thr Thr Leu Lys 
                485                 490                 495     


Leu Ala Asp Phe Gly Leu Ala Lys His Val Val Arg Pro Ile Phe Thr 
            500                 505                 510         


Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu Ile Leu Ser Glu Lys 
        515                 520                 525             


Gly Tyr Gly Leu Glu Val Asp Met Trp Ala Ala Gly Val Ile Leu Tyr 
    530                 535                 540                 


Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Ser Pro Glu Arg Asp Gln 
545                 550                 555                 560 


Asp Glu Leu Phe Asn Ile Ile Gln Leu Gly His Phe Glu Phe Leu Pro 
                565                 570                 575     


Pro Tyr Trp Asp Asn Ile Ser Asp Ala Ala Lys Asp Leu Val Ser Arg 
            580                 585                 590         


Leu Leu Val Val Asp Pro Lys Lys Arg Tyr Thr Ala His Gln Val Leu 
        595                 600                 605             


Gln His Pro Trp Ile Glu Thr Ala Gly Lys Thr Asn Thr Val Lys Arg 
    610                 615                 620                 


Gln Lys Gln Val Ser Pro Ser Ser Glu Gly His Phe Arg Ser Gln His 
625                 630                 635                 640 


Lys Arg Val Val Glu Gln Val Ser 
                645             


<210>  2915
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCLRE1A__Homo_sapiens__NP_055696

<400>  2915

Met Leu Glu Asp Ile Ser Glu Glu Asp Ile Trp Glu Tyr Lys Ser Lys 
1               5                   10                  15      


Arg Lys Pro Lys Arg Val Asp Pro Asn Asn Gly Ser Lys Asn Ile Leu 
            20                  25                  30          


Lys Ser Val Glu Lys Ala Thr Asp Gly Lys Tyr Gln Ser Lys Arg Ser 
        35                  40                  45              


Arg Asn Arg Lys Arg Ala Ala Glu Ala Lys Glu Val Lys Asp His Glu 
    50                  55                  60                  


Val Pro Leu Gly Asn Ala Gly Cys Gln Thr Ser Val Ala Ser Ser Gln 
65                  70                  75                  80  


Asn Ser Ser Cys Gly Asp Gly Ile Gln Gln Thr Gln Asp Lys Glu Thr 
                85                  90                  95      


Thr Pro Gly Lys Leu Cys Arg Thr Gln Lys Ser Gln His Val Ser Pro 
            100                 105                 110         


Lys Ile Arg Pro Val Tyr Asp Gly Tyr Cys Pro Asn Cys Gln Met Pro 
        115                 120                 125             


Phe Ser Ser Leu Ile Gly Gln Thr Pro Arg Trp His Val Phe Glu Cys 
    130                 135                 140                 


Leu Asp Ser Pro Pro Arg Ser Glu Thr Glu Cys Pro Asp Gly Leu Leu 
145                 150                 155                 160 


Cys Thr Ser Thr Ile Pro Phe His Tyr Lys Arg Tyr Thr His Phe Leu 
                165                 170                 175     


Leu Ala Gln Ser Arg Ala Gly Asp His Pro Phe Ser Ser Pro Ser Pro 
            180                 185                 190         


Ala Ser Gly Gly Ser Phe Ser Glu Thr Lys Ser Gly Val Leu Cys Ser 
        195                 200                 205             


Leu Glu Glu Arg Trp Ser Ser Tyr Gln Asn Gln Thr Asp Asn Ser Val 
    210                 215                 220                 


Ser Asn Asp Pro Leu Leu Met Thr Gln Tyr Phe Lys Lys Ser Pro Ser 
225                 230                 235                 240 


Leu Thr Glu Ala Ser Glu Lys Ile Ser Thr His Ile Gln Thr Ser Gln 
                245                 250                 255     


Gln Ala Leu Gln Phe Thr Asp Phe Val Glu Asn Asp Lys Leu Val Gly 
            260                 265                 270         


Val Ala Leu Arg Leu Ala Asn Asn Ser Glu His Ile Asn Leu Pro Leu 
        275                 280                 285             


Pro Glu Asn Asp Phe Ser Asp Cys Glu Ile Ser Tyr Ser Pro Leu Gln 
    290                 295                 300                 


Ser Asp Glu Asp Thr His Asp Ile Asp Glu Lys Pro Asp Asp Ser Gln 
305                 310                 315                 320 


Glu Gln Leu Phe Phe Thr Glu Ser Ser Lys Asp Gly Ser Leu Glu Glu 
                325                 330                 335     


Asp Asp Asp Ser Cys Gly Phe Phe Lys Lys Arg His Gly Pro Leu Leu 
            340                 345                 350         


Lys Asp Gln Asp Glu Ser Cys Pro Lys Val Asn Ser Phe Leu Thr Arg 
        355                 360                 365             


Asp Lys Tyr Asp Glu Gly Leu Tyr Arg Phe Asn Ser Leu Asn Asp Leu 
    370                 375                 380                 


Ser Gln Pro Ile Ser Gln Asn Asn Glu Ser Thr Leu Pro Tyr Asp Leu 
385                 390                 395                 400 


Ala Cys Thr Gly Gly Asp Phe Val Leu Phe Pro Pro Ala Leu Ala Gly 
                405                 410                 415     


Lys Leu Ala Ala Ser Val His Gln Ala Thr Lys Ala Lys Pro Asp Glu 
            420                 425                 430         


Pro Glu Phe His Ser Ala Gln Ser Asn Lys Gln Lys Gln Val Ile Glu 
        435                 440                 445             


Glu Ser Ser Val Tyr Asn Gln Val Ser Leu Pro Leu Val Lys Ser Leu 
    450                 455                 460                 


Met Leu Lys Pro Phe Glu Ser Gln Val Glu Gly Tyr Leu Ser Ser Gln 
465                 470                 475                 480 


Pro Thr Gln Asn Thr Ile Arg Lys Leu Ser Ser Glu Asn Leu Asn Ala 
                485                 490                 495     


Lys Asn Asn Thr Asn Ser Ala Cys Phe Cys Arg Lys Ala Leu Glu Gly 
            500                 505                 510         


Val Pro Val Gly Lys Ala Thr Ile Leu Asn Thr Glu Asn Leu Ser Ser 
        515                 520                 525             


Thr Pro Ala Pro Lys Tyr Leu Lys Ile Leu Pro Ser Gly Leu Lys Tyr 
    530                 535                 540                 


Asn Ala Arg His Pro Ser Thr Lys Val Met Lys Gln Met Asp Ile Gly 
545                 550                 555                 560 


Val Tyr Phe Gly Leu Pro Pro Lys Arg Lys Glu Glu Lys Leu Leu Gly 
                565                 570                 575     


Glu Ser Ala Leu Glu Gly Ile Asn Leu Asn Pro Val Pro Ser Pro Asn 
            580                 585                 590         


Gln Lys Arg Ser Ser Gln Cys Lys Arg Lys Ala Glu Lys Ser Leu Ser 
        595                 600                 605             


Asp Leu Glu Phe Asp Ala Ser Thr Leu His Glu Ser Gln Leu Ser Val 
    610                 615                 620                 


Glu Leu Ser Ser Glu Arg Ser Gln Arg Gln Lys Lys Arg Cys Arg Lys 
625                 630                 635                 640 


Ser Asn Ser Leu Gln Glu Gly Ala Cys Gln Lys Arg Ser Asp His Leu 
                645                 650                 655     


Ile Asn Thr Glu Ser Glu Ala Val Asn Leu Ser Lys Val Lys Val Phe 
            660                 665                 670         


Thr Lys Ser Ala His Gly Gly Leu Gln Arg Gly Asn Lys Lys Ile Pro 
        675                 680                 685             


Glu Ser Ser Asn Val Gly Gly Ser Arg Lys Lys Thr Cys Pro Phe Tyr 
    690                 695                 700                 


Lys Lys Ile Pro Gly Thr Gly Phe Thr Val Asp Ala Phe Gln Tyr Gly 
705                 710                 715                 720 


Val Val Glu Gly Cys Thr Ala Tyr Phe Leu Thr His Phe His Ser Asp 
                725                 730                 735     


His Tyr Ala Gly Leu Ser Lys His Phe Thr Phe Pro Val Tyr Cys Ser 
            740                 745                 750         


Glu Ile Thr Gly Asn Leu Leu Lys Asn Lys Leu His Val Gln Glu Gln 
        755                 760                 765             


Tyr Ile His Pro Leu Pro Leu Asp Thr Glu Cys Ile Val Asn Gly Val 
    770                 775                 780                 


Lys Val Val Leu Leu Asp Ala Asn His Cys Pro Gly Ala Val Met Ile 
785                 790                 795                 800 


Leu Phe Tyr Leu Pro Asn Gly Thr Val Ile Leu His Thr Gly Asp Phe 
                805                 810                 815     


Arg Ala Asp Pro Ser Met Glu Arg Ser Leu Leu Ala Asp Gln Lys Val 
            820                 825                 830         


His Met Leu Tyr Leu Asp Thr Thr Tyr Cys Ser Pro Glu Tyr Thr Phe 
        835                 840                 845             


Pro Ser Gln Gln Glu Val Ile Arg Phe Ala Ile Asn Thr Ala Phe Glu 
    850                 855                 860                 


Ala Val Thr Leu Asn Pro His Ala Leu Val Val Cys Gly Thr Tyr Ser 
865                 870                 875                 880 


Ile Gly Lys Glu Lys Val Phe Leu Ala Ile Ala Asp Val Leu Gly Ser 
                885                 890                 895     


Lys Val Gly Met Ser Gln Glu Lys Tyr Lys Thr Leu Gln Cys Leu Asn 
            900                 905                 910         


Ile Pro Glu Ile Asn Ser Leu Ile Thr Thr Asp Met Cys Ser Ser Leu 
        915                 920                 925             


Val His Leu Leu Pro Met Met Gln Ile Asn Phe Lys Gly Leu Gln Ser 
    930                 935                 940                 


His Leu Lys Lys Cys Gly Gly Lys Tyr Asn Gln Ile Leu Ala Phe Arg 
945                 950                 955                 960 


Pro Thr Gly Trp Thr His Ser Asn Lys Phe Thr Arg Ile Ala Asp Val 
                965                 970                 975     


Ile Pro Gln Thr Lys Gly Asn Ile Ser Ile Tyr Gly Ile Pro Tyr Ser 
            980                 985                 990         


Glu His Ser Ser Tyr Leu Glu Met  Lys Arg Phe Val Gln  Trp Leu Lys 
        995                 1000                 1005             


Pro Gln  Lys Ile Ile Pro Thr  Val Asn Val Gly Thr  Trp Lys Ser 
    1010                 1015                 1020             


Arg Ser  Thr Met Glu Lys Tyr  Phe Arg Glu Trp Lys  Leu Glu Ala 
    1025                 1030                 1035             


Gly Tyr  
    1040 


<210>  2916
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCLRE1C__Homo_sapiens__NP_001029027

<400>  2916

Met Ser Ser Phe Glu Gly Gln Met Ala Glu Tyr Pro Thr Ile Ser Ile 
1               5                   10                  15      


Asp Arg Phe Asp Arg Glu Asn Leu Arg Ala Arg Ala Tyr Phe Leu Ser 
            20                  25                  30          


His Cys His Lys Asp His Met Lys Gly Leu Arg Ala Pro Thr Leu Lys 
        35                  40                  45              


Arg Arg Leu Glu Cys Ser Leu Lys Val Tyr Leu Tyr Cys Ser Pro Val 
    50                  55                  60                  


Thr Lys Glu Leu Leu Leu Thr Ser Pro Lys Tyr Arg Phe Trp Lys Lys 
65                  70                  75                  80  


Arg Ile Ile Ser Ile Glu Ile Glu Thr Pro Thr Gln Ile Ser Leu Val 
                85                  90                  95      


Asp Glu Ala Ser Gly Glu Lys Glu Glu Ile Val Val Thr Leu Leu Pro 
            100                 105                 110         


Ala Gly His Cys Pro Gly Ser Val Met Phe Leu Phe Gln Gly Asn Asn 
        115                 120                 125             


Gly Thr Val Leu Tyr Thr Gly Asp Phe Arg Leu Ala Gln Gly Glu Ala 
    130                 135                 140                 


Ala Arg Met Glu Leu Leu His Ser Gly Gly Arg Val Lys Asp Ile Gln 
145                 150                 155                 160 


Ser Val Tyr Leu Asp Thr Thr Phe Cys Asp Pro Arg Phe Tyr Gln Ile 
                165                 170                 175     


Pro Ser Arg Glu Glu Cys Leu Ser Gly Val Leu Glu Leu Val Arg Ser 
            180                 185                 190         


Trp Ile Thr Arg Ser Pro Tyr His Val Val Trp Leu Asn Cys Lys Ala 
        195                 200                 205             


Ala Tyr Gly Tyr Glu Tyr Leu Phe Thr Asn Leu Ser Glu Glu Leu Gly 
    210                 215                 220                 


Val Gln Val His Val Asn Lys Leu Asp Met Phe Arg Asn Met Pro Glu 
225                 230                 235                 240 


Ile Leu His His Leu Thr Thr Asp Arg Asn Thr Gln Ile His Ala Cys 
                245                 250                 255     


Arg His Pro Lys Ala Glu Glu Tyr Phe Gln Trp Ser Lys Leu Pro Cys 
            260                 265                 270         


Gly Ile Thr Ser Arg Asn Arg Ile Pro Leu His Ile Ile Ser Ile Lys 
        275                 280                 285             


Pro Ser Thr Met Trp Phe Gly Glu Arg Ser Arg Lys Thr Asn Val Ile 
    290                 295                 300                 


Val Arg Thr Gly Glu Ser Ser Tyr Arg Ala Cys Phe Ser Phe His Ser 
305                 310                 315                 320 


Ser Tyr Ser Glu Ile Lys Asp Phe Leu Ser Tyr Leu Cys Pro Val Asn 
                325                 330                 335     


Ala Tyr Pro Asn Val Ile Pro Val Gly Thr Thr Met Asp Lys Val Val 
            340                 345                 350         


Glu Ile Leu Lys Pro Leu Cys Arg Ser Ser Gln Ser Thr Glu Pro Lys 
        355                 360                 365             


Tyr Lys Pro Leu Gly Lys Leu Lys Arg Ala Arg Thr Val His Arg Asp 
    370                 375                 380                 


Ser Glu Glu Glu Asp Asp Tyr Leu Phe Asp Asp Pro Leu Pro Ile Pro 
385                 390                 395                 400 


Leu Arg His Lys Val Pro Tyr Pro Glu Thr Phe His Pro Glu Val Phe 
                405                 410                 415     


Ser Met Thr Ala Val Ser Glu Lys Gln Pro Glu Lys Leu Arg Gln Thr 
            420                 425                 430         


Pro Gly Cys Cys Arg Ala Glu Cys Met Gln Ser Ser Arg Phe Thr Asn 
        435                 440                 445             


Phe Val Asp Cys Glu Glu Ser Asn Ser Glu Ser Glu Glu Glu Val Gly 
    450                 455                 460                 


Ile Pro Ala Ser Leu Gln Gly Asp Leu Gly Ser Val Leu His Leu Gln 
465                 470                 475                 480 


Lys Ala Asp Gly Asp Val Pro Gln Trp Glu Val Phe Phe Lys Arg Asn 
                485                 490                 495     


Asp Glu Ile Thr Asp Glu Ser Leu Glu Asn Phe Pro Ser Ser Thr Val 
            500                 505                 510         


Ala Gly Gly Ser Gln Ser Pro Lys Leu Phe Ser Asp Ser Asp Gly Glu 
        515                 520                 525             


Ser Thr His Ile Ser Ser Gln Asn Ser Ser Gln Ser Thr His Ile Thr 
    530                 535                 540                 


Glu Gln Gly Ser Gln Gly Trp Asp Ser Gln Ser Asp Thr Val Leu Leu 
545                 550                 555                 560 


Ser Ser Gln Glu Arg Asn Ser Gly Asp Ile Thr Ser Leu Asp Lys Ala 
                565                 570                 575     


Asp Tyr Arg Pro Thr Ile Lys Glu Asn Ile Pro Ala Ser Leu Met Glu 
            580                 585                 590         


Gln Asn Val Ile Cys Pro Lys Asp Thr Tyr Ser Asp Leu Lys Ser Arg 
        595                 600                 605             


Asp Lys Asp Val Thr Ile Val Pro Ser Thr Gly Glu Pro Thr Thr Leu 
    610                 615                 620                 


Ser Ser Glu Thr His Ile Pro Glu Glu Lys Ser Leu Leu Asn Leu Ser 
625                 630                 635                 640 


Thr Asn Ala Asp Ser Gln Ser Ser Ser Asp Phe Glu Val Pro Ser Thr 
                645                 650                 655     


Pro Glu Ala Glu Leu Pro Lys Arg Glu His Leu Gln Tyr Leu Tyr Glu 
            660                 665                 670         


Lys Leu Ala Thr Gly Glu Ser Ile Ala Val Lys Lys Arg Lys Cys Ser 
        675                 680                 685             


Leu Leu Asp Thr 
    690         


<210>  2917
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCN__Homo_sapiens__NP_598010

<400>  2917

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  2918
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCP1A__Homo_sapiens__NP_001277136

<400>  2918

Met Ala Asp Val Val Glu Glu Glu Thr Arg Arg Ser Gln Gln Ala Ala 
1               5                   10                  15      


Arg Asp Lys Gln Ser Pro Ser Gln Ala Asn Gly Cys Ser Asp His Arg 
            20                  25                  30          


Pro Ile Asp Ile Leu Glu Met Leu Ser Arg Ala Lys Asp Glu Tyr Glu 
        35                  40                  45              


Arg Ser Ala Pro Ser Gly His Lys His Leu Thr Val Glu Glu Leu Phe 
    50                  55                  60                  


Gly Thr Ser Leu Pro Lys Glu Gln Pro Ala Val Val Gly Leu Asp Ser 
65                  70                  75                  80  


Glu Glu Met Glu Arg Leu Pro Gly Asp Ala Ser Gln Lys Glu Pro Asn 
                85                  90                  95      


Ser Phe Leu Pro Phe Pro Phe Glu Gln Leu Gly Gly Ala Pro Gln Ser 
            100                 105                 110         


Glu Thr Leu Gly Val Pro Ser Ala Ala His His Ser Val Gln Pro Glu 
        115                 120                 125             


Ile Thr Thr Pro Val Leu Ile Thr Pro Ala Ser Ile Thr Gln Ser Asn 
    130                 135                 140                 


Glu Lys His Ala Pro Thr Tyr Thr Ile Pro Leu Ser Pro Val Leu Ser 
145                 150                 155                 160 


Pro Thr Leu Pro Ala Glu Ala Pro Thr Ala Gln Val Pro Pro Ser Leu 
                165                 170                 175     


Pro Arg Asn Ser Thr Met Met Gln Ala Val Lys Thr Thr Pro Arg Gln 
            180                 185                 190         


Arg Ser Pro Leu Leu Asn Gln Pro Val Pro Glu Leu Ser His Ala Ser 
        195                 200                 205             


Leu Ile Ala Asn Gln Ser Pro Phe Arg Ala Pro Leu Asn Val Thr Asn 
    210                 215                 220                 


Thr Ala Gly Thr Ser Leu Pro Ser Val Asp Leu Leu Gln Lys Leu Arg 
225                 230                 235                 240 


Leu Thr Pro Gln His Asp Gln Ile Gln Thr Gln Pro Leu Gly Lys Gly 
                245                 250                 255     


Ala Met Val Ala Ser Phe Ser Pro Ala Ala Gly Gln Leu Ala Thr Pro 
            260                 265                 270         


Glu Ser Phe Ile Glu Pro Pro Ser Lys Thr Ala Ala Ala Arg Val Ala 
        275                 280                 285             


Ala Ser Ala Ser Leu Ser Asn Met Val Leu Ala Pro Leu Gln Ser Met 
    290                 295                 300                 


Gln Gln Asn Gln Asp Pro Glu Val Phe Val Gln Pro Lys Val Leu Ser 
305                 310                 315                 320 


Ser Ala Ile Pro Val Ala Gly Ala Pro Leu Val Thr Ala Thr Thr Thr 
                325                 330                 335     


Ala Val Ser Ser Val Leu Leu Ala Pro Ser Val Phe Gln Gln Thr Val 
            340                 345                 350         


Thr Arg Ser Ser Asp Leu Glu Arg Lys Ala Ser Ser Pro Ser Pro Leu 
        355                 360                 365             


Thr Ile Gly Thr Pro Glu Ser Gln Arg Lys Pro Ser Ile Ile Leu Ser 
    370                 375                 380                 


Lys Ser Gln Leu Gln Asp Thr Leu Ile His Leu Ile Lys Asn Asp Ser 
385                 390                 395                 400 


Ser Phe Leu Ser Thr Leu His Glu Val Tyr Leu Gln Val Leu Thr Lys 
                405                 410                 415     


Asn Lys Asp Asn His Asn Leu 
            420             


<210>  2919
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCP1B__Homo_sapiens__NP_689853

<400>  2919

Met Ala Ala Val Ala Ala Gly Gly Leu Val Gly Lys Gly Arg Asp Ile 
1               5                   10                  15      


Ser Leu Ala Ala Leu Gln Arg His Asp Pro Tyr Ile Asn Arg Ile Val 
            20                  25                  30          


Asp Val Ala Ser Gln Val Ala Leu Tyr Thr Phe Gly His Arg Ala Asn 
        35                  40                  45              


Glu Trp Glu Lys Thr Asp Val Glu Gly Thr Leu Phe Val Tyr Thr Arg 
    50                  55                  60                  


Ser Ala Ser Pro Lys His Gly Phe Thr Ile Met Asn Arg Leu Ser Met 
65                  70                  75                  80  


Glu Asn Arg Thr Glu Pro Ile Thr Lys Asp Leu Asp Phe Gln Leu Gln 
                85                  90                  95      


Asp Pro Phe Leu Leu Tyr Arg Asn Ala Arg Leu Ser Ile Tyr Gly Ile 
            100                 105                 110         


Trp Phe Tyr Asp Lys Glu Glu Cys Gln Arg Ile Ala Glu Leu Met Lys 
        115                 120                 125             


Asn Leu Thr Gln Tyr Glu Gln Leu Lys Ala His Gln Gly Thr Gly Ala 
    130                 135                 140                 


Gly Ile Ser Pro Val Ile Leu Asn Ser Gly Glu Gly Lys Glu Val Asp 
145                 150                 155                 160 


Ile Leu Arg Met Leu Ile Lys Ala Lys Asp Glu Tyr Thr Lys Cys Lys 
                165                 170                 175     


Thr Cys Ser Glu Pro Lys Lys Ile Thr Ser Ser Ser Ala Ile Tyr Asp 
            180                 185                 190         


Asn Pro Asn Leu Ile Lys Pro Ile Pro Val Lys Pro Ser Glu Asn Gln 
        195                 200                 205             


Gln Gln Arg Ile Pro Gln Pro Asn Gln Thr Leu Asp Pro Glu Pro Gln 
    210                 215                 220                 


His Leu Ser Leu Thr Ala Leu Phe Gly Lys Gln Asp Lys Ala Thr Cys 
225                 230                 235                 240 


Gln Glu Thr Val Glu Pro Pro Gln Thr Leu His Gln Gln Gln Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Glu Lys Leu Pro Ile Arg Gln Gly Val Val Arg 
            260                 265                 270         


Ser Leu Ser Tyr Glu Glu Pro Arg Arg His Ser Pro Pro Ile Glu Lys 
        275                 280                 285             


Gln Leu Cys Pro Ala Ile Gln Lys Leu Met Val Arg Ser Ala Asp Leu 
    290                 295                 300                 


His Pro Leu Ser Glu Leu Pro Glu Asn Arg Pro Cys Glu Asn Gly Ser 
305                 310                 315                 320 


Thr His Ser Ala Gly Glu Phe Phe Thr Gly Pro Val Gln Pro Gly Ser 
                325                 330                 335     


Pro His Asn Ile Gly Thr Ser Arg Gly Val Gln Asn Ala Ser Arg Thr 
            340                 345                 350         


Gln Asn Leu Phe Glu Lys Leu Gln Ser Thr Pro Gly Ala Ala Asn Lys 
        355                 360                 365             


Cys Asp Pro Ser Thr Pro Ala Pro Ala Ser Ser Ala Ala Leu Asn Arg 
    370                 375                 380                 


Ser Arg Ala Pro Thr Ser Val Thr Pro Val Ala Pro Gly Lys Gly Leu 
385                 390                 395                 400 


Ala Gln Pro Pro Gln Ala Tyr Phe Asn Gly Ser Leu Pro Pro Gln Thr 
                405                 410                 415     


Val Gly His Gln Ala His Gly Arg Glu Gln Ser Thr Leu Pro Arg Gln 
            420                 425                 430         


Thr Leu Pro Ile Ser Gly Ser Gln Thr Gly Ser Ser Gly Val Ile Ser 
        435                 440                 445             


Pro Gln Glu Leu Leu Lys Lys Leu Gln Ile Val Gln Gln Glu Gln Gln 
    450                 455                 460                 


Leu His Ala Ser Asn Arg Pro Ala Leu Ala Ala Lys Phe Pro Val Leu 
465                 470                 475                 480 


Ala Gln Ser Ser Gly Thr Gly Lys Pro Leu Glu Ser Trp Ile Asn Lys 
                485                 490                 495     


Thr Pro Asn Thr Glu Gln Gln Thr Pro Leu Phe Gln Val Ile Ser Pro 
            500                 505                 510         


Gln Arg Ile Pro Ala Thr Ala Ala Pro Ser Leu Leu Met Ser Pro Met 
        515                 520                 525             


Val Phe Ala Gln Pro Thr Ser Val Pro Pro Lys Glu Arg Glu Ser Gly 
    530                 535                 540                 


Leu Leu Pro Val Gly Gly Gln Glu Pro Pro Ala Ala Ala Thr Ser Leu 
545                 550                 555                 560 


Leu Leu Pro Ile Gln Ser Pro Glu Pro Ser Val Ile Thr Ser Ser Pro 
                565                 570                 575     


Leu Thr Lys Leu Gln Leu Gln Glu Ala Leu Leu Tyr Leu Ile Gln Asn 
            580                 585                 590         


Asp Asp Asn Phe Leu Asn Ile Ile Tyr Glu Ala Tyr Leu Phe Ser Met 
        595                 600                 605             


Thr Gln Ala Ala Met Lys Lys Thr Met 
    610                 615         


<210>  2920
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCPS__Homo_sapiens__NP_054745

<400>  2920

Met Ala Asp Ala Ala Pro Gln Leu Gly Lys Arg Lys Arg Glu Leu Asp 
1               5                   10                  15      


Val Glu Glu Ala His Ala Ala Ser Thr Glu Glu Lys Glu Ala Gly Val 
            20                  25                  30          


Gly Asn Gly Thr Cys Ala Pro Val Arg Leu Pro Phe Ser Gly Phe Arg 
        35                  40                  45              


Leu Gln Lys Val Leu Arg Glu Ser Ala Arg Asp Lys Ile Ile Phe Leu 
    50                  55                  60                  


His Gly Lys Val Asn Glu Ala Ser Gly Asp Gly Asp Gly Glu Asp Ala 
65                  70                  75                  80  


Val Val Ile Leu Glu Lys Thr Pro Phe Gln Val Glu Gln Val Ala Gln 
                85                  90                  95      


Leu Leu Thr Gly Ser Pro Glu Leu Gln Leu Gln Phe Ser Asn Asp Ile 
            100                 105                 110         


Tyr Ser Thr Tyr His Leu Phe Pro Pro Arg Gln Leu Asn Asp Val Lys 
        115                 120                 125             


Thr Thr Val Val Tyr Pro Ala Thr Glu Lys His Leu Gln Lys Tyr Leu 
    130                 135                 140                 


Arg Gln Asp Leu Arg Leu Ile Arg Glu Thr Gly Asp Asp Tyr Arg Asn 
145                 150                 155                 160 


Ile Thr Leu Pro His Leu Glu Ser Gln Ser Leu Ser Ile Gln Trp Val 
                165                 170                 175     


Tyr Asn Ile Leu Asp Lys Lys Ala Glu Ala Asp Arg Ile Val Phe Glu 
            180                 185                 190         


Asn Pro Asp Pro Ser Asp Gly Phe Val Leu Ile Pro Asp Leu Lys Trp 
        195                 200                 205             


Asn Gln Gln Gln Leu Asp Asp Leu Tyr Leu Ile Ala Ile Cys His Arg 
    210                 215                 220                 


Arg Gly Ile Arg Ser Leu Arg Asp Leu Thr Pro Glu His Leu Pro Leu 
225                 230                 235                 240 


Leu Arg Asn Ile Leu His Gln Gly Gln Glu Ala Ile Leu Gln Arg Tyr 
                245                 250                 255     


Arg Met Lys Gly Asp His Leu Arg Val Tyr Leu His Tyr Leu Pro Ser 
            260                 265                 270         


Tyr Tyr His Leu His Val His Phe Thr Ala Leu Gly Phe Glu Ala Pro 
        275                 280                 285             


Gly Ser Gly Val Glu Arg Ala His Leu Leu Ala Glu Val Ile Glu Asn 
    290                 295                 300                 


Leu Glu Cys Asp Pro Arg His Tyr Gln Gln Arg Thr Leu Thr Phe Ala 
305                 310                 315                 320 


Leu Arg Ala Asp Asp Pro Leu Leu Lys Leu Leu Gln Glu Ala Gln Gln 
                325                 330                 335     


Ser 
    


<210>  2921
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCST1__Homo_sapiens__NP_001137159

<400>  2921

Met Asp Ile Lys His His Gln Asn Gly Thr Arg Gly Gln Arg Arg Lys 
1               5                   10                  15      


Gln Pro His Thr Thr Val Gln Arg Leu Leu Thr Trp Gly Leu Pro Val 
            20                  25                  30          


Ser Cys Ser Trp Phe Leu Trp Arg Gln Pro Gly Glu Phe Pro Val Thr 
        35                  40                  45              


Ala Leu Leu Leu Gly Ala Gly Ala Gly Gly Leu Leu Ala Ile Gly Leu 
    50                  55                  60                  


Gly Ala Met Gly Trp Gly Thr Ser Pro His Ile Arg Cys Ala Ser Leu 
65                  70                  75                  80  


Leu Leu Val Pro Lys Met Leu Gly Lys Glu Gly Arg Leu Phe Val Leu 
                85                  90                  95      


Gly Tyr Ala Leu Ala Ala Ile Tyr Val Gly Pro Val Ala Asn Leu Arg 
            100                 105                 110         


His Asn Leu Asn Asn Val Ile Ala Ser Leu Gly Cys Thr Val Glu Leu 
        115                 120                 125             


Gln Ile Asn Asn Thr Arg Ala Ala Trp Arg Ile Ser Thr Ala Pro Leu 
    130                 135                 140                 


Arg Ala Met Phe Lys Asp Leu Leu Ser Ser Lys Glu Leu Leu Arg Ala 
145                 150                 155                 160 


Glu Thr Arg Asn Ile Ser Ala Thr Phe Glu Asp Leu Asp Ala Gln Val 
                165                 170                 175     


Asn Ser Glu Thr Gly Tyr Thr Pro Glu Asp Thr Met Asp Ser Gly Glu 
            180                 185                 190         


Thr Ala Gln Gly Arg Glu Ala Arg Gln Ala Pro Ala Ser Arg Leu His 
        195                 200                 205             


Leu Ser Thr Gln Lys Met Tyr Glu Leu Lys Thr Lys Leu Arg Cys Ser 
    210                 215                 220                 


Tyr Val Val Asn Gln Ala Ile Leu Ser Cys Arg Arg Trp Phe Asp Arg 
225                 230                 235                 240 


Lys His Glu Gln Cys Met Lys His Ile Trp Val Pro Leu Leu Thr His 
                245                 250                 255     


Leu Leu Cys Leu Pro Met Lys Phe Lys Phe Phe Cys Gly Ile Ala Lys 
            260                 265                 270         


Val Met Glu Val Trp Cys Arg Asn Arg Ile Pro Val Glu Gly Asn Phe 
        275                 280                 285             


Gly Gln Thr Tyr Asp Ser Leu Asn Gln Ser Ile Arg Gly Leu Asp Gly 
    290                 295                 300                 


Glu Phe Ser Ala Asn Ile Asp Phe Lys Glu Glu Lys Gln Ala Gly Val 
305                 310                 315                 320 


Leu Gly Leu Asn Thr Ser Trp Glu Arg Val Ser Thr Glu Val Arg Asp 
                325                 330                 335     


Tyr Val Tyr Arg Gln Glu Ala Arg Leu Glu Trp Ala Leu Gly Leu Leu 
            340                 345                 350         


His Val Leu Leu Ser Cys Thr Phe Leu Leu Val Leu His Ala Ser Phe 
        355                 360                 365             


Ser Tyr Met Asp Ser Tyr Asn His Asp Ile Arg Phe Asp Asn Ile Tyr 
    370                 375                 380                 


Ile Ser Thr Tyr Phe Cys Gln Ile Asp Asp Arg Arg Lys Lys Leu Gly 
385                 390                 395                 400 


Lys Arg Thr Leu Leu Pro Leu Arg Lys Ala Glu Glu Lys Thr Val Ile 
                405                 410                 415     


Phe Pro Cys Lys Pro Thr Ile Gln Ala Ser Glu Met Ser Asn Val Val 
            420                 425                 430         


Arg Glu Leu Leu Glu Thr Leu Pro Ile Leu Leu Leu Leu Val Val Leu 
        435                 440                 445             


Cys Gly Leu Asp Trp Ala Leu Tyr Ser Ile Phe Asp Thr Ile Arg His 
    450                 455                 460                 


His Ser Phe Leu Gln Tyr Ser Phe Arg Ser Ser His Lys Leu Glu Val 
465                 470                 475                 480 


Lys Val Gly Gly Asp Ser Met Leu Ala Arg Leu Leu Arg Lys Thr Ile 
                485                 490                 495     


Gly Ala Leu Asn Thr Ser Ser Glu Thr Val Met Glu Ser Asn Asn Met 
            500                 505                 510         


Pro Cys Leu Pro Gln Pro Val Gly Leu Asp Ala Arg Ala Tyr Trp Arg 
        515                 520                 525             


Ala Ala Val Pro Ile Gly Leu Leu Val Cys Leu Cys Leu Leu Gln Ala 
    530                 535                 540                 


Phe Gly Tyr Arg Leu Arg Arg Val Ile Ala Ala Phe Tyr Phe Pro Lys 
545                 550                 555                 560 


Arg Glu Lys Lys Arg Ile Leu Phe Leu Tyr Asn Asp Leu Leu Lys Lys 
                565                 570                 575     


Arg Ala Ala Phe Thr Lys Leu Arg Arg Ala Ala Ile Leu Arg Arg Glu 
            580                 585                 590         


Arg Gln Gln Lys Ala Pro Arg His Pro Leu Ala Asp Ile Leu His Arg 
        595                 600                 605             


Gly Cys Pro Leu Leu Arg Arg Trp Leu Cys Arg Arg Cys Val Val Cys 
    610                 615                 620                 


Gln Ala Pro Glu Thr Pro Glu Ser Tyr Val Cys Arg Thr Leu Asp Cys 
625                 630                 635                 640 


Glu Ala Val Tyr Cys Trp Ser Cys Trp Asp Asp Met Arg Gln Arg Cys 
                645                 650                 655     


Pro Val Cys Thr Pro Arg Glu Glu Leu Ser Ser Ser Ala Phe Ser Asp 
            660                 665                 670         


Ser Asn Asp Asp Thr Ala Tyr Ala Gly 
        675                 680     


<210>  2922
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCST2__Homo_sapiens__NP_653223

<400>  2922

Met Pro Lys Val Met Lys Asp Val Val His Pro Leu Gly Gly Glu Glu 
1               5                   10                  15      


Pro Ser Met Ala Arg Ala Val Val Arg Ser Val Gly Gly Phe Thr Leu 
            20                  25                  30          


Gly Leu Ser Leu Ala Thr Ala Tyr Gly Leu Leu Glu Leu Leu Val Glu 
        35                  40                  45              


Gly His Ser Pro Trp Gly Cys Leu Val Gly Thr Leu Thr Leu Ala Ala 
    50                  55                  60                  


Phe Leu Ser Leu Gly Met Gly Phe Ser Arg Gln Val Arg Ala Thr Val 
65                  70                  75                  80  


Leu Leu Leu Leu Pro Gln Ala Phe Ser Arg Gln Gly Arg Thr Leu Leu 
                85                  90                  95      


Leu Val Ala Ala Phe Gly Leu Val Leu Gln Gly Pro Cys Ala Asn Thr 
            100                 105                 110         


Leu Arg Asn Phe Thr Arg Ala Ser Glu Ala Val Ala Cys Gly Ala Glu 
        115                 120                 125             


Leu Ala Leu Asn Gln Thr Ala Glu Val Leu Gln Arg Ala Lys Gln Pro 
    130                 135                 140                 


Leu Val Ser Ala Leu Asn Lys Ile Lys Ala Ile Ala Arg Lys Thr Lys 
145                 150                 155                 160 


Glu Val Ala Asp Arg Val Arg Lys Phe Phe Arg Ser Ile Met Asp Gly 
                165                 170                 175     


Val Lys His Ile Ala Arg Ala Leu Arg Asn Val Trp Gln Trp Leu Leu 
            180                 185                 190         


His Ile Gly Asp Val Cys Asn Ser Glu Leu Gly Asn Pro Tyr Leu Lys 
        195                 200                 205             


Cys Ala Arg Val Phe Asp Asp Ala Lys Asp Ser Cys Met Met Val Ile 
    210                 215                 220                 


Pro Gln Ala Tyr His Leu Cys Tyr Val Leu Met Pro Phe Lys Leu Ala 
225                 230                 235                 240 


Leu Cys Gly Leu Ala Ser Leu Val Gln Val Phe Cys Val Ile Pro Lys 
                245                 250                 255     


Tyr Ile Gln Pro Phe Leu Arg Gln Thr Ile Gly Thr Pro Val Ile Gln 
            260                 265                 270         


Leu Leu Asn Arg Val Arg Gln Glu Phe Glu Phe Asn Met Thr Ala Thr 
        275                 280                 285             


His His Phe Ser Val Asp Leu Asn Ala Ser Arg Ser Leu Ser Gln Val 
    290                 295                 300                 


Ala Met Asp Leu His Glu Ala Val Ser Met Lys Leu His Arg Val Arg 
305                 310                 315                 320 


Glu Ala Leu Ala Leu Met Gly Phe Thr Thr Pro Leu Leu Leu Val Leu 
                325                 330                 335     


Leu Tyr Leu Gln Ala Leu Phe Tyr Arg Tyr Cys Tyr Leu Asn Trp Asp 
            340                 345                 350         


His Tyr Asp Asn Ile Tyr Ile Thr Ser Arg Phe Leu Arg Met Glu Ala 
        355                 360                 365             


Val Arg Ser Thr Ala Gly Leu Pro Thr Val Leu Pro Leu Ser Ala His 
    370                 375                 380                 


Glu Ala Arg Arg Tyr Ile Pro Pro Gly Ser Ile Phe Leu Ser Gln Trp 
385                 390                 395                 400 


Glu Lys Phe Phe Tyr Ile Leu Glu Thr Phe Asn Leu Ile Arg His Leu 
                405                 410                 415     


Leu Leu Val Leu Phe Leu Val Phe Leu Asp Tyr Ala Val Phe Trp Val 
            420                 425                 430         


Leu Asp Leu Ala Arg His Gln Leu Gln Gly Glu Ile Val Ala Arg Ser 
        435                 440                 445             


Pro Val Leu Val Ser Leu Thr Val Glu Gly Thr Gly Tyr Ala Gly Asn 
    450                 455                 460                 


Ile Tyr Arg Asp Leu Val Ser Ala Phe Asp Val Leu Gln Gln Gly Asn 
465                 470                 475                 480 


Ile Ser Ile Leu Ser Arg Arg Cys Leu Leu Arg Pro Ser Glu Pro Asp 
                485                 490                 495     


Ser Thr Gly Tyr Ile Val Ile Gly Val Met Tyr Gly Leu Cys Phe Phe 
            500                 505                 510         


Ile Thr Leu Phe Gly Ser Tyr Val Ser Arg Leu Arg Arg Val Ile Cys 
        515                 520                 525             


Ala Ser Tyr Tyr Pro Ser Arg Glu Gln Glu Arg Ile Ser Tyr Leu Tyr 
    530                 535                 540                 


Asn Val Leu Leu Ser Arg Arg Thr Asn Leu Leu Ala Ala Leu His Arg 
545                 550                 555                 560 


Ser Val Arg Arg Arg Ala Ala Asp Gln Gly His Arg Ser Ala Phe Leu 
                565                 570                 575     


Val Leu Ala Ser Arg Cys Pro Cys Leu Gly Pro Phe Val Ser His Phe 
            580                 585                 590         


Trp Leu His Gln Ala Tyr Cys Leu Gly Cys Gly Gln Pro Gln Asp Glu 
        595                 600                 605             


Gly Asp Met Glu Asn Thr Val Ser Cys Ser Thr Pro Gly Cys Gln Gly 
    610                 615                 620                 


Leu Tyr Cys Leu Thr Cys Phe Arg Leu Leu Asp Asn Thr Cys Ser Val 
625                 630                 635                 640 


Cys Ala Ser Pro Leu Ser Tyr Gln Gly Asp Leu Asp Leu Glu Leu Asp 
                645                 650                 655     


Ser Ser Asp Glu Glu Gly Pro Gln Leu Trp Leu Ala Ala Ala Gln Arg 
            660                 665                 670         


Lys Asp Pro Glu Gln Ala Trp Leu Leu Gln Gln Gln Leu Gln Glu Val 
        675                 680                 685             


Leu Gly Arg Ser Leu Ser Met Glu Ser Thr Ser Glu Ser Ser Asp Leu 
    690                 695                 700                 


Asp Glu Glu Lys Gly Pro Gln Gln Arg Lys His Gly Gln Gln Pro Leu 
705                 710                 715                 720 


Pro Glu Ala His Gln Pro Val Ser Ile Leu Thr Ser Pro Glu Pro His 
                725                 730                 735     


Arg Pro Pro Glu Thr Ser Ser Ala Thr Lys Gly Ala Pro Thr Pro Ala 
            740                 745                 750         


Ser Glu Pro Ser Val Pro Leu Ser Pro Pro Ser Leu Pro Asp Pro Ser 
        755                 760                 765             


His Pro Pro Pro Lys 
    770             


<210>  2923
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCSTAMP__Homo_sapiens__XP_005251132

<400>  2923

Met Gly Ile Trp Thr Ser Gly Thr Asp Ile Phe Leu Ser Leu Trp Glu 
1               5                   10                  15      


Ile Tyr Val Ser Pro Arg Ser Pro Gly Trp Met Asp Phe Ile Gln His 
            20                  25                  30          


Leu Gly Val Cys Cys Leu Val Ala Leu Ile Ser Val Gly Leu Leu Ser 
        35                  40                  45              


Val Ala Ala Cys Trp Phe Leu Pro Ser Ile Ile Ala Ala Ala Ala Ser 
    50                  55                  60                  


Trp Ile Ile Thr Cys Val Leu Leu Cys Cys Ser Lys His Ala Arg Cys 
65                  70                  75                  80  


Phe Ile Leu Leu Val Phe Leu Ser Cys Gly Leu Arg Glu Gly Arg Asn 
                85                  90                  95      


Ala Leu Ile Ala Ala Gly Thr Gly Ile Val Ile Leu Gly His Val Glu 
            100                 105                 110         


Asn Ile Phe His Asn Phe Lys Gly Leu Leu Asp Gly Met Thr Cys Asn 
        115                 120                 125             


Leu Arg Ala Lys Ser Phe Ser Ile His Phe Pro Leu Leu Lys Lys Tyr 
    130                 135                 140                 


Ile Glu Ala Ile Gln Trp Ile Tyr Gly Leu Ala Thr Pro Leu Ser Val 
145                 150                 155                 160 


Phe Asp Asp Leu Val Ser Trp Asn Gln Thr Leu Ala Val Ser Leu Phe 
                165                 170                 175     


Ser Pro Ser His Val Leu Glu Ala Gln Leu Asn Asp Ser Lys Gly Glu 
            180                 185                 190         


Val Leu Ser Val Leu Tyr Gln Met Ala Thr Thr Thr Glu Val Leu Ser 
        195                 200                 205             


Ser Leu Gly Gln Lys Leu Leu Ala Phe Ala Gly Leu Ser Leu Val Leu 
    210                 215                 220                 


Leu Gly Thr Gly Leu Phe Met Lys Arg Phe Leu Gly Pro Cys Gly Trp 
225                 230                 235                 240 


Lys Tyr Glu Asn Ile Tyr Ile Thr Arg Gln Phe Val Gln Phe Asp Glu 
                245                 250                 255     


Arg Glu Arg His Gln Gln Arg Pro Cys Val Leu Pro Leu Asn Lys Glu 
            260                 265                 270         


Glu Arg Arg Lys Tyr Val Ile Ile Pro Thr Phe Trp Pro Thr Pro Lys 
        275                 280                 285             


Glu Arg Lys Asn Leu Gly Leu Phe Phe Leu Pro Ile Leu Ile His Leu 
    290                 295                 300                 


Cys Ile Trp Val Leu Phe Ala Ala Val Asp Tyr Leu Leu Tyr Arg Leu 
305                 310                 315                 320 


Ile Phe Ser Val Ser Lys Gln Phe Gln Ser Leu Pro Gly Phe Glu Val 
                325                 330                 335     


His Leu Lys Leu His Gly Glu Lys Gln Gly Thr Gln Asp Ile Ile His 
            340                 345                 350         


Asp Ser Ser Phe Asn Ile Ser Val Phe Glu Pro Asn Cys Ile Pro Lys 
        355                 360                 365             


Pro Lys Phe Leu Leu Ser Glu Thr Trp Val Pro Leu Ser Val Ile Leu 
    370                 375                 380                 


Leu Ile Leu Val Met Leu Gly Leu Leu Ser Ser Ile Leu Met Gln Leu 
385                 390                 395                 400 


Lys Ile Leu Val Ser Ala Ser Phe Tyr Pro Ser Val Glu Arg Lys Arg 
                405                 410                 415     


Ile Gln Tyr Leu His Ala Lys Leu Leu Lys Lys Arg Ser Lys Gln Pro 
            420                 425                 430         


Leu Gly Glu Val Lys Arg Arg Leu Ser Leu Tyr Leu Thr Lys Ile His 
        435                 440                 445             


Phe Trp Leu Pro Val Leu Lys Met Ile Arg Lys Lys Gln Met Asp Met 
    450                 455                 460                 


Ala Ser Ala Asp Lys Ser 
465                 470 


<210>  2924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCTD__Homo_sapiens__NP_001012750

<400>  2924

Met Val Gly Gly Gly Gln Pro Cys Gly Pro Asn Met Ser Glu Val Ser 
1               5                   10                  15      


Cys Lys Lys Arg Asp Asp Tyr Leu Glu Trp Pro Glu Tyr Phe Met Ala 
            20                  25                  30          


Val Ala Phe Leu Ser Ala Gln Arg Ser Lys Asp Pro Asn Ser Gln Val 
        35                  40                  45              


Gly Ala Cys Ile Val Asn Ser Glu Asn Lys Ile Val Gly Ile Gly Tyr 
    50                  55                  60                  


Asn Gly Met Pro Asn Gly Cys Ser Asp Asp Val Leu Pro Trp Arg Arg 
65                  70                  75                  80  


Thr Ala Glu Asn Lys Leu Asp Thr Lys Tyr Pro Tyr Val Cys His Ala 
                85                  90                  95      


Glu Leu Asn Ala Ile Met Asn Lys Asn Ser Thr Asp Val Lys Gly Cys 
            100                 105                 110         


Ser Met Tyr Val Ala Leu Phe Pro Cys Asn Glu Cys Ala Lys Leu Ile 
        115                 120                 125             


Ile Gln Ala Gly Ile Lys Glu Val Ile Phe Met Ser Asp Lys Tyr His 
    130                 135                 140                 


Asp Ser Asp Glu Ala Thr Ala Ala Arg Leu Leu Phe Asn Met Ala Gly 
145                 150                 155                 160 


Val Thr Phe Arg Lys Phe Ile Pro Lys Cys Ser Lys Ile Val Ile Asp 
                165                 170                 175     


Phe Asp Ser Ile Asn Ser Arg Pro Ser Gln Lys Leu Gln 
            180                 185                 


<210>  2925
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCT__Homo_sapiens__NP_001123361

<400>  2925

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Ile Ser Asn Arg Leu Leu 
385                 390                 395                 400 


Tyr Asn Ala Thr Thr Asn Ile Leu Glu His Val Arg Lys Glu Lys Ala 
                405                 410                 415     


Thr Lys Glu Leu Pro Ser Leu His Val Leu Val Leu His Ser Phe Thr 
            420                 425                 430         


Asp Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp 
        435                 440                 445             


Ala Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn 
    450                 455                 460                 


Met Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr 
465                 470                 475                 480 


Ser Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val 
                485                 490                 495     


Glu Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr 
            500                 505                 510         


Leu Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr 
        515                 520                 525             


Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser 
    530                 535                 540                 


Ser Lys Arg Tyr Thr Glu Glu Ala 
545                 550         


<210>  2926
<211>  1253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCTN1__Homo_sapiens__NP_001128512

<400>  2926

Met Ala Gln Ser Lys Arg His Val Tyr Ser Arg Thr Pro Ser Gly Ser 
1               5                   10                  15      


Arg Met Ser Ala Glu Ala Ser Ala Arg Pro Leu Arg Val Gly Ser Arg 
            20                  25                  30          


Val Glu Val Ile Gly Lys Gly His Arg Gly Thr Val Ala Tyr Val Gly 
        35                  40                  45              


Ala Thr Leu Phe Ala Thr Gly Lys Trp Val Gly Val Ile Leu Asp Glu 
    50                  55                  60                  


Ala Lys Gly Lys Asn Asp Gly Thr Val Gln Gly Arg Lys Tyr Phe Thr 
65                  70                  75                  80  


Cys Asp Glu Gly His Gly Ile Phe Val Arg Gln Ser Gln Ile Gln Val 
                85                  90                  95      


Phe Glu Asp Gly Ala Asp Thr Thr Ser Pro Glu Thr Pro Asp Ser Ser 
            100                 105                 110         


Ala Ser Lys Val Leu Lys Arg Glu Gly Thr Asp Thr Thr Ala Lys Thr 
        115                 120                 125             


Ser Lys Leu Pro Thr Arg Pro Ala Ser Thr Gly Val Ala Gly Ala Ser 
    130                 135                 140                 


Ser Ser Leu Gly Pro Ser Gly Ser Ala Ser Ala Gly Glu Leu Ser Ser 
145                 150                 155                 160 


Ser Glu Pro Ser Thr Pro Ala Gln Thr Pro Leu Ala Ala Pro Ile Ile 
                165                 170                 175     


Pro Thr Pro Val Leu Thr Ser Pro Gly Ala Val Pro Pro Leu Pro Ser 
            180                 185                 190         


Pro Ser Lys Glu Glu Glu Gly Leu Arg Ala Gln Val Arg Asp Leu Glu 
        195                 200                 205             


Glu Lys Leu Glu Thr Leu Arg Leu Lys Arg Ala Glu Asp Lys Ala Lys 
    210                 215                 220                 


Leu Lys Glu Leu Glu Lys His Lys Ile Gln Leu Glu Gln Val Gln Glu 
225                 230                 235                 240 


Trp Lys Ser Lys Met Gln Glu Gln Gln Ala Asp Leu Gln Arg Arg Leu 
                245                 250                 255     


Lys Glu Ala Arg Lys Glu Ala Lys Glu Ala Leu Glu Ala Lys Glu Arg 
            260                 265                 270         


Tyr Met Glu Glu Met Ala Asp Thr Ala Asp Ala Ile Glu Met Ala Thr 
        275                 280                 285             


Leu Asp Lys Glu Met Ala Glu Glu Arg Ala Glu Ser Leu Gln Gln Glu 
    290                 295                 300                 


Val Glu Ala Leu Lys Glu Arg Val Asp Glu Leu Thr Thr Asp Leu Glu 
305                 310                 315                 320 


Ile Leu Lys Ala Glu Ile Glu Glu Lys Gly Ser Asp Gly Ala Ala Ser 
                325                 330                 335     


Ser Tyr Gln Leu Lys Gln Leu Glu Glu Gln Asn Ala Arg Leu Lys Asp 
            340                 345                 350         


Ala Leu Val Arg Met Arg Asp Leu Ser Ser Ser Glu Lys Gln Glu His 
        355                 360                 365             


Val Lys Leu Gln Lys Leu Met Glu Lys Lys Asn Gln Glu Leu Glu Val 
    370                 375                 380                 


Val Arg Gln Gln Arg Glu Arg Leu Gln Glu Glu Leu Ser Gln Ala Glu 
385                 390                 395                 400 


Ser Thr Ile Asp Glu Leu Lys Glu Gln Val Asp Ala Ala Leu Gly Ala 
                405                 410                 415     


Glu Glu Met Val Glu Met Leu Thr Asp Arg Asn Leu Asn Leu Glu Glu 
            420                 425                 430         


Lys Val Arg Glu Leu Arg Glu Thr Val Gly Asp Leu Glu Ala Met Asn 
        435                 440                 445             


Glu Met Asn Asp Glu Leu Gln Glu Asn Ala Arg Glu Thr Glu Leu Glu 
    450                 455                 460                 


Leu Arg Glu Gln Leu Asp Met Ala Gly Ala Arg Val Arg Glu Ala Gln 
465                 470                 475                 480 


Lys Arg Val Glu Ala Ala Gln Glu Thr Val Ala Asp Tyr Gln Gln Thr 
                485                 490                 495     


Ile Lys Lys Tyr Arg Gln Leu Thr Ala His Leu Gln Asp Val Asn Arg 
            500                 505                 510         


Glu Leu Thr Asn Gln Gln Glu Ala Ser Val Glu Arg Gln Gln Gln Pro 
        515                 520                 525             


Pro Pro Glu Thr Phe Asp Phe Lys Ile Lys Phe Ala Glu Thr Lys Ala 
    530                 535                 540                 


His Ala Lys Ala Ile Glu Met Glu Leu Arg Gln Met Glu Val Ala Gln 
545                 550                 555                 560 


Ala Asn Arg His Met Ser Leu Leu Thr Ala Phe Met Pro Asp Ser Phe 
                565                 570                 575     


Leu Arg Pro Gly Gly Asp His Asp Cys Val Leu Val Leu Leu Leu Met 
            580                 585                 590         


Pro Arg Leu Ile Cys Lys Ala Glu Leu Ile Arg Lys Gln Ala Gln Glu 
        595                 600                 605             


Lys Phe Glu Leu Ser Glu Asn Cys Ser Glu Arg Pro Gly Leu Arg Gly 
    610                 615                 620                 


Ala Ala Gly Glu Gln Leu Ser Phe Ala Ala Gly Leu Val Tyr Ser Leu 
625                 630                 635                 640 


Ser Leu Leu Gln Ala Thr Leu His Arg Tyr Glu His Ala Leu Ser Gln 
                645                 650                 655     


Cys Ser Val Asp Val Tyr Lys Lys Val Gly Ser Leu Tyr Pro Glu Met 
            660                 665                 670         


Ser Ala His Glu Arg Ser Leu Asp Phe Leu Ile Glu Leu Leu His Lys 
        675                 680                 685             


Asp Gln Leu Asp Glu Thr Val Asn Val Glu Pro Leu Thr Lys Ala Ile 
    690                 695                 700                 


Lys Tyr Tyr Gln His Leu Tyr Ser Ile His Leu Ala Glu Gln Pro Glu 
705                 710                 715                 720 


Asp Cys Thr Met Gln Leu Ala Asp His Ile Lys Phe Thr Gln Ser Ala 
                725                 730                 735     


Leu Asp Cys Met Ser Val Glu Val Gly Arg Leu Arg Ala Phe Leu Gln 
            740                 745                 750         


Gly Gly Gln Glu Ala Thr Asp Ile Ala Leu Leu Leu Arg Asp Leu Glu 
        755                 760                 765             


Thr Ser Cys Ser Asp Ile Arg Gln Phe Cys Lys Lys Ile Arg Arg Arg 
    770                 775                 780                 


Met Pro Gly Thr Asp Ala Pro Gly Ile Pro Ala Ala Leu Ala Phe Gly 
785                 790                 795                 800 


Pro Gln Val Ser Asp Thr Leu Leu Asp Cys Arg Lys His Leu Thr Trp 
                805                 810                 815     


Val Val Ala Val Leu Gln Glu Val Ala Ala Ala Ala Ala Gln Leu Ile 
            820                 825                 830         


Ala Pro Leu Ala Glu Asn Glu Gly Leu Leu Val Ala Ala Leu Glu Glu 
        835                 840                 845             


Leu Ala Phe Lys Ala Ser Glu Gln Ile Tyr Gly Thr Pro Ser Ser Ser 
    850                 855                 860                 


Pro Tyr Glu Cys Leu Arg Gln Ser Cys Asn Ile Leu Ile Ser Thr Met 
865                 870                 875                 880 


Asn Lys Leu Ala Thr Ala Met Gln Glu Gly Glu Tyr Asp Ala Glu Arg 
                885                 890                 895     


Pro Pro Ser Lys Pro Pro Pro Val Glu Leu Arg Ala Ala Ala Leu Arg 
            900                 905                 910         


Ala Glu Ile Thr Asp Ala Glu Gly Leu Gly Leu Lys Leu Glu Asp Arg 
        915                 920                 925             


Glu Thr Val Ile Lys Glu Leu Lys Lys Ser Leu Lys Ile Lys Gly Glu 
    930                 935                 940                 


Glu Leu Ser Glu Ala Asn Val Arg Leu Ser Leu Leu Glu Lys Lys Leu 
945                 950                 955                 960 


Asp Ser Ala Ala Lys Asp Ala Asp Glu Arg Ile Glu Lys Val Gln Thr 
                965                 970                 975     


Arg Leu Glu Glu Thr Gln Ala Leu Leu Arg Lys Lys Glu Lys Glu Phe 
            980                 985                 990         


Glu Glu Thr Met Asp Ala Leu Gln  Ala Asp Ile Asp Gln  Leu Glu Ala 
        995                 1000                 1005             


Glu Lys  Ala Glu Leu Lys Gln  Arg Leu Asn Ser Gln  Ser Lys Arg 
    1010                 1015                 1020             


Thr Ile  Glu Gly Leu Arg Gly  Pro Pro Pro Ser Gly  Ile Ala Thr 
    1025                 1030                 1035             


Leu Val  Ser Gly Ile Ala Gly  Gly Ala Ile Pro Gly  Gln Ala Pro 
    1040                 1045                 1050             


Gly Ser  Val Pro Gly Pro Gly  Leu Val Lys Asp Ser  Pro Leu Leu 
    1055                 1060                 1065             


Leu Gln  Gln Ile Ser Ala Met  Arg Leu His Ile Ser  Gln Leu Gln 
    1070                 1075                 1080             


His Glu  Asn Ser Ile Leu Lys  Gly Ala Gln Met Lys  Ala Ser Leu 
    1085                 1090                 1095             


Ala Ser  Leu Pro Pro Leu His  Val Ala Lys Leu Ser  His Glu Gly 
    1100                 1105                 1110             


Pro Gly  Ser Glu Leu Pro Ala  Gly Ala Leu Tyr Arg  Lys Thr Ser 
    1115                 1120                 1125             


Gln Leu  Leu Glu Thr Leu Asn  Gln Leu Ser Thr His  Thr His Val 
    1130                 1135                 1140             


Val Asp  Ile Thr Arg Thr Ser  Pro Ala Ala Lys Ser  Pro Ser Ala 
    1145                 1150                 1155             


Gln Leu  Met Glu Gln Val Ala  Gln Leu Lys Ser Leu  Ser Asp Thr 
    1160                 1165                 1170             


Val Glu  Lys Leu Lys Asp Glu  Val Leu Lys Glu Thr  Val Ser Gln 
    1175                 1180                 1185             


Arg Pro  Gly Ala Thr Val Pro  Thr Asp Phe Ala Thr  Phe Pro Ser 
    1190                 1195                 1200             


Ser Ala  Phe Leu Arg Ala Lys  Glu Glu Gln Gln Asp  Asp Thr Val 
    1205                 1210                 1215             


Tyr Met  Gly Lys Val Thr Phe  Ser Cys Ala Ala Gly  Phe Gly Gln 
    1220                 1225                 1230             


Arg His  Arg Leu Val Leu Thr  Gln Glu Gln Leu His  Gln Leu His 
    1235                 1240                 1245             


Ser Arg  Leu Ile Ser 
    1250             


<210>  2927
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCTN2__Homo_sapiens__NP_001248341

<400>  2927

Met Ala Asp Pro Lys Tyr Ala Asp Leu Pro Gly Ile Ala Arg Asn Glu 
1               5                   10                  15      


Pro Asp Val Tyr Glu Thr Ser Asp Leu Pro Glu Asp Asp Gln Ala Glu 
            20                  25                  30          


Phe Asp Ala Glu Leu Glu Glu Leu Thr Ser Thr Ser Val Glu His Ile 
        35                  40                  45              


Ile Val Asn Pro Asn Ala Ala Tyr Asp Lys Phe Lys Asp Lys Arg Val 
    50                  55                  60                  


Gly Thr Lys Gly Leu Asp Phe Ser Asp Arg Ile Gly Lys Thr Lys Arg 
65                  70                  75                  80  


Thr Gly Tyr Glu Ser Gly Glu Tyr Glu Met Leu Gly Glu Gly Leu Gly 
                85                  90                  95      


Val Lys Glu Thr Pro Gln Gln Lys Tyr Gln Arg Leu Leu His Glu Val 
            100                 105                 110         


Gln Glu Leu Thr Thr Glu Val Glu Lys Ile Lys Thr Thr Val Lys Glu 
        115                 120                 125             


Ser Ala Thr Glu Glu Lys Leu Thr Pro Val Leu Leu Ala Lys Gln Leu 
    130                 135                 140                 


Ala Ala Leu Lys Gln Gln Leu Val Ala Ser His Leu Glu Lys Leu Leu 
145                 150                 155                 160 


Gly Pro Asp Ala Ala Ile Asn Leu Thr Asp Pro Asp Gly Ala Leu Ala 
                165                 170                 175     


Lys Arg Leu Leu Leu Gln Leu Glu Ala Thr Lys Asn Ser Lys Gly Gly 
            180                 185                 190         


Ser Gly Gly Lys Thr Thr Gly Thr Pro Pro Asp Ser Ser Leu Val Thr 
        195                 200                 205             


Tyr Glu Leu His Ser Arg Pro Glu Gln Asp Lys Phe Ser Gln Ala Ala 
    210                 215                 220                 


Lys Val Ala Glu Leu Glu Lys Arg Leu Thr Glu Leu Glu Thr Ala Val 
225                 230                 235                 240 


Arg Cys Asp Gln Asp Ala Gln Asn Pro Leu Ser Ala Gly Leu Gln Gly 
                245                 250                 255     


Ala Cys Leu Met Glu Thr Val Glu Leu Leu Gln Ala Lys Val Ser Ala 
            260                 265                 270         


Leu Asp Leu Ala Val Leu Asp Gln Val Glu Ala Arg Leu Gln Ser Val 
        275                 280                 285             


Leu Gly Lys Val Asn Glu Ile Ala Lys His Lys Ala Ser Val Glu Asp 
    290                 295                 300                 


Ala Asp Thr Gln Ser Lys Val His Gln Leu Tyr Glu Thr Ile Gln Arg 
305                 310                 315                 320 


Trp Ser Pro Ile Ala Ser Thr Leu Pro Glu Leu Val Gln Arg Leu Val 
                325                 330                 335     


Thr Ile Lys Gln Leu His Glu Gln Ala Met Gln Phe Gly Gln Leu Leu 
            340                 345                 350         


Thr His Leu Asp Thr Thr Gln Gln Met Ile Ala Asn Ser Leu Lys Asp 
        355                 360                 365             


Asn Thr Thr Leu Leu Thr Gln Val Gln Thr Thr Met Arg Glu Asn Leu 
    370                 375                 380                 


Ala Thr Val Glu Gly Asn Phe Ala Ser Ile Asp Glu Arg Met Lys Lys 
385                 390                 395                 400 


Leu Gly Lys 
            


<210>  2928
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCTN3__Homo_sapiens__NP_001268354

<400>  2928

Met Ala Gly Leu Thr Asp Leu Gln Arg Leu Gln Ala Arg Val Glu Glu 
1               5                   10                  15      


Leu Glu Arg Trp Val Tyr Gly Pro Gly Gly Ala Arg Gly Ser Arg Lys 
            20                  25                  30          


Val Ala Asp Gly Leu Val Lys Val Gln Val Ala Leu Gly Asn Ile Ser 
        35                  40                  45              


Ser Lys Arg Glu Arg Val Lys Ile Leu Tyr Lys Lys Ile Glu Asp Leu 
    50                  55                  60                  


Ile Lys Tyr Leu Asp Pro Glu Tyr Ile Asp Arg Ile Ala Ile Pro Asp 
65                  70                  75                  80  


Ala Ser Lys Leu Gln Phe Ile Leu Ala Ala Val Pro Glu His Ala Ala 
                85                  90                  95      


Arg Leu Gln Arg Leu Ala Gln Ile His Ile Gln Gln Gln Asp Gln Cys 
            100                 105                 110         


Val Glu Ile Thr Glu Glu Ser Lys Ala Leu Leu Glu Glu Tyr Asn Lys 
        115                 120                 125             


Thr Thr Met Leu Leu Ser Lys Gln Phe Val Gln Trp Asp Glu Leu Leu 
    130                 135                 140                 


Cys Gln Leu Glu Ala Ala Thr Gln Val Lys Pro Ala Glu Glu 
145                 150                 155             


<210>  2929
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCTN4__Homo_sapiens__NP_001129115

<400>  2929

Met Ala Ser Leu Leu Gln Ser Asp Arg Val Leu Tyr Leu Val Gln Gly 
1               5                   10                  15      


Glu Lys Lys Val Arg Ala Pro Leu Ser Gln Leu Tyr Phe Cys Arg Tyr 
            20                  25                  30          


Cys Ser Glu Leu Arg Ser Leu Glu Cys Val Ser His Glu Val Asp Ser 
        35                  40                  45              


His Tyr Cys Pro Ser Cys Leu Glu Asn Met Pro Ser Ala Glu Ala Lys 
    50                  55                  60                  


Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe Asp Cys Pro Gly Cys Met 
65                  70                  75                  80  


His Thr Leu Ser Thr Arg Ala Thr Ser Ile Ser Thr Gln Leu Pro Asp 
                85                  90                  95      


Asp Pro Ala Lys Thr Thr Met Lys Lys Ala Tyr Tyr Leu Ala Cys Gly 
            100                 105                 110         


Phe Cys Arg Trp Thr Ser Arg Asp Val Gly Met Ala Asp Lys Ser Val 
        115                 120                 125             


Ala Ser Gly Gly Trp Gln Glu Pro Glu Asn Pro His Thr Gln Arg Met 
    130                 135                 140                 


Asn Lys Leu Ile Glu Tyr Tyr Gln Gln Leu Ala Gln Lys Glu Lys Val 
145                 150                 155                 160 


Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg Arg Asn Tyr Met Pro Leu 
                165                 170                 175     


Ala Phe Ser Gln His Thr Ile His Val Val Asp Lys Tyr Gly Leu Gly 
            180                 185                 190         


Thr Arg Leu Gln Arg Pro Arg Ala Gly Ala Ser Ile Ser Thr Leu Ala 
        195                 200                 205             


Gly Leu Ser Leu Lys Glu Gly Glu Asp Gln Lys Glu Ile Lys Ile Glu 
    210                 215                 220                 


Pro Ala Gln Ala Val Asp Glu Val Glu Pro Leu Pro Glu Asp Tyr Tyr 
225                 230                 235                 240 


Thr Arg Pro Val Asn Leu Thr Glu Val Thr Thr Leu Gln Gln Arg Leu 
                245                 250                 255     


Leu Gln Pro Asp Phe Gln Pro Val Cys Ala Ser Gln Leu Tyr Pro Arg 
            260                 265                 270         


His Lys His Leu Leu Ile Lys Arg Ser Leu Arg Cys Arg Lys Cys Glu 
        275                 280                 285             


His Asn Leu Ser Lys Pro Glu Phe Asn Pro Thr Ser Ile Lys Phe Lys 
    290                 295                 300                 


Ile Gln Leu Val Ala Val Asn Tyr Ile Pro Glu Val Arg Ile Met Ser 
305                 310                 315                 320 


Ile Pro Asn Leu Arg Tyr Met Lys Glu Ser Gln Val Leu Leu Thr Leu 
                325                 330                 335     


Thr Asn Pro Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu 
            340                 345                 350         


Glu Gly Asp Pro Asp Asp Ile Asn Ser Thr Ala Lys Val Val Val Pro 
        355                 360                 365             


Pro Lys Glu Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp 
    370                 375                 380                 


Glu Leu Ala Glu Pro Gln Asp Phe Gln Asp Asp Pro Asp Ile Ile Ala 
385                 390                 395                 400 


Phe Arg Lys Ala Asn Lys Val Gly Ile Phe Ile Lys Val Thr Pro Gln 
                405                 410                 415     


Arg Glu Glu Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe 
            420                 425                 430         


Lys Asn Leu Ala Ala Pro Ile Arg Pro Ile Glu Glu Ser Asp Gln Gly 
        435                 440                 445             


Thr Glu Val Ile Trp Leu Thr Gln His Val Glu Leu Ser Leu Gly Pro 
    450                 455                 460                 


Leu Leu Pro 
465         


<210>  2930
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCTN5__Homo_sapiens__NP_001185940

<400>  2930

Met Glu Leu Gly Glu Leu Leu Tyr Asn Lys Ser Glu Tyr Ile Glu Thr 
1               5                   10                  15      


Ala Ser Gly Asn Lys Val Ser Arg Gln Ser Val Leu Cys Gly Ser Gln 
            20                  25                  30          


Asn Ile Val Leu Asn Gly Lys Asn Phe Val Ile Ser Val Phe Leu Ser 
        35                  40                  45              


Pro Tyr Ile Arg Cys His Ser Ala Cys Arg Asp Arg Lys Arg Ser Asp 
    50                  55                  60                  


Glu Ser Val Arg Leu Ser Val Asn Asn Arg Glu Trp Trp Gly Leu Val 
65                  70                  75                  80  


Asn Trp Arg Met 
                


<210>  2931
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCTN6__Homo_sapiens__NP_006562

<400>  2931

Met Ala Glu Lys Thr Gln Lys Ser Val Lys Ile Ala Pro Gly Ala Val 
1               5                   10                  15      


Val Cys Val Glu Ser Glu Ile Arg Gly Asp Val Thr Ile Gly Pro Arg 
            20                  25                  30          


Thr Val Ile His Pro Lys Ala Arg Ile Ile Ala Glu Ala Gly Pro Ile 
        35                  40                  45              


Val Ile Gly Glu Gly Asn Leu Ile Glu Glu Gln Ala Leu Ile Ile Asn 
    50                  55                  60                  


Ala Tyr Pro Asp Asn Ile Thr Pro Asp Thr Glu Asp Pro Glu Pro Lys 
65                  70                  75                  80  


Pro Met Ile Ile Gly Thr Asn Asn Val Phe Glu Val Gly Cys Tyr Ser 
                85                  90                  95      


Gln Ala Met Lys Met Gly Asp Asn Asn Val Ile Glu Ser Lys Ala Tyr 
            100                 105                 110         


Val Gly Arg Asn Val Ile Leu Thr Ser Gly Cys Ile Ile Gly Ala Cys 
        115                 120                 125             


Cys Asn Leu Asn Thr Phe Glu Val Ile Pro Glu Asn Thr Val Ile Tyr 
    130                 135                 140                 


Gly Ala Asp Cys Leu Arg Arg Val Gln Thr Glu Arg Pro Gln Pro Gln 
145                 150                 155                 160 


Thr Leu Gln Leu Asp Phe Leu Met Lys Ile Leu Pro Asn Tyr His His 
                165                 170                 175     


Leu Lys Lys Thr Met Lys Gly Ser Ser Thr Pro Val Lys Asn 
            180                 185                 190 


<210>  2932
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCUN1D1__Homo_sapiens__NP_065691

<400>  2932

Met Asn Lys Leu Lys Ser Ser Gln Lys Asp Lys Val Arg Gln Phe Met 
1               5                   10                  15      


Ile Phe Thr Gln Ser Ser Glu Lys Thr Ala Val Ser Cys Leu Ser Gln 
            20                  25                  30          


Asn Asp Trp Lys Leu Asp Val Ala Thr Asp Asn Phe Phe Gln Asn Pro 
        35                  40                  45              


Glu Leu Tyr Ile Arg Glu Ser Val Lys Gly Ser Leu Asp Arg Lys Lys 
    50                  55                  60                  


Leu Glu Gln Leu Tyr Asn Arg Tyr Lys Asp Pro Gln Asp Glu Asn Lys 
65                  70                  75                  80  


Ile Gly Ile Asp Gly Ile Gln Gln Phe Cys Asp Asp Leu Ala Leu Asp 
                85                  90                  95      


Pro Ala Ser Ile Ser Val Leu Ile Ile Ala Trp Lys Phe Arg Ala Ala 
            100                 105                 110         


Thr Gln Cys Glu Phe Ser Lys Gln Glu Phe Met Asp Gly Met Thr Glu 
        115                 120                 125             


Leu Gly Cys Asp Ser Ile Glu Lys Leu Lys Ala Gln Ile Pro Lys Met 
    130                 135                 140                 


Glu Gln Glu Leu Lys Glu Pro Gly Arg Phe Lys Asp Phe Tyr Gln Phe 
145                 150                 155                 160 


Thr Phe Asn Phe Ala Lys Asn Pro Gly Gln Lys Gly Leu Asp Leu Glu 
                165                 170                 175     


Met Ala Ile Ala Tyr Trp Asn Leu Val Leu Asn Gly Arg Phe Lys Phe 
            180                 185                 190         


Leu Asp Leu Trp Asn Lys Phe Leu Leu Glu His His Lys Arg Ser Ile 
        195                 200                 205             


Pro Lys Asp Thr Trp Asn Leu Leu Leu Asp Phe Ser Thr Met Ile Ala 
    210                 215                 220                 


Asp Asp Met Ser Asn Tyr Asp Glu Glu Gly Ala Trp Pro Val Leu Ile 
225                 230                 235                 240 


Asp Asp Phe Val Glu Phe Ala Arg Pro Gln Ile Ala Gly Thr Lys Ser 
                245                 250                 255     


Thr Thr Val 
            


<210>  2933
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCX__Homo_sapiens__NP_000546

<400>  2933

Met Lys Thr Leu Pro Leu His Ser His Cys Thr Glu Met Gln Arg Leu 
1               5                   10                  15      


Leu Pro Lys Leu Glu Met Leu Thr Leu Gly Ser Ser Phe Cys Ser Leu 
            20                  25                  30          


Gln Gly Glu Phe Cys Gln Ala Met Asp Ser Phe Thr Thr Val Ser His 
        35                  40                  45              


Val Gly Met Cys Glu Glu Thr Asp Ala Ser Phe Asn Val Phe Ser Pro 
    50                  55                  60                  


Lys Phe Gln Phe Asp Arg Ser His Cys Gln Ser Leu Arg Phe His Gln 
65                  70                  75                  80  


Asn Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser 
                85                  90                  95      


Arg Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His 
            100                 105                 110         


Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser 
        115                 120                 125             


Asn Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg 
    130                 135                 140                 


Tyr Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser 
145                 150                 155                 160 


Phe Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile 
                165                 170                 175     


Asn Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg 
            180                 185                 190         


Lys Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys 
        195                 200                 205             


Ser Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn 
    210                 215                 220                 


Pro Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro 
225                 230                 235                 240 


Gln Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp 
                245                 250                 255     


Phe Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro 
            260                 265                 270         


Arg Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe 
        275                 280                 285             


Glu Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly 
    290                 295                 300                 


Val Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu 
305                 310                 315                 320 


His Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu 
                325                 330                 335     


Lys Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys 
            340                 345                 350         


Arg Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser 
        355                 360                 365             


Pro Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg 
    370                 375                 380                 


Ser Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu 
385                 390                 395                 400 


Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro 
                405                 410                 415     


Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp 
            420                 425                 430         


Asp Ser Asp Ser Leu Gly Asp Ser Met 
        435                 440     


<210>  2934
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCXR__Homo_sapiens__NP_057370

<400>  2934

Met Glu Leu Phe Leu Ala Gly Arg Arg Val Leu Val Thr Gly Ala Gly 
1               5                   10                  15      


Lys Gly Ile Gly Arg Gly Thr Val Gln Ala Leu His Ala Thr Gly Ala 
            20                  25                  30          


Arg Val Val Ala Val Ser Arg Thr Gln Ala Asp Leu Asp Ser Leu Val 
        35                  40                  45              


Arg Glu Cys Pro Gly Ile Glu Pro Val Cys Val Asp Leu Gly Asp Trp 
    50                  55                  60                  


Glu Ala Thr Glu Arg Ala Leu Gly Ser Val Gly Pro Val Asp Leu Leu 
65                  70                  75                  80  


Val Asn Asn Ala Ala Val Ala Leu Leu Gln Pro Phe Leu Glu Val Thr 
                85                  90                  95      


Lys Glu Ala Phe Asp Arg Ser Phe Glu Val Asn Leu Arg Ala Val Ile 
            100                 105                 110         


Gln Val Ser Gln Ile Val Ala Arg Gly Leu Ile Ala Arg Gly Val Pro 
        115                 120                 125             


Gly Ala Ile Val Asn Val Ser Ser Gln Cys Ser Gln Arg Ala Val Thr 
    130                 135                 140                 


Asn His Ser Val Tyr Cys Ser Thr Lys Gly Ala Leu Asp Met Leu Thr 
145                 150                 155                 160 


Lys Val Met Ala Leu Glu Leu Gly Pro His Lys Ile Arg Val Asn Ala 
                165                 170                 175     


Val Asn Pro Thr Val Val Met Thr Ser Met Gly Gln Ala Thr Trp Ser 
            180                 185                 190         


Asp Pro His Lys Ala Lys Thr Met Leu Asn Arg Ile Pro Leu Gly Lys 
        195                 200                 205             


Phe Ala Glu Val Glu His Val Val Asn Ala Ile Leu Phe Leu Leu Ser 
    210                 215                 220                 


Asp Arg Ser Gly Met Thr Thr Gly Ser Thr Leu Pro Val Glu Gly Gly 
225                 230                 235                 240 


Phe Trp Ala Cys 
                


<210>  2935
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDAH1__Homo_sapiens__XP_011539460

<400>  2935

Met Val Asp Met Met Lys Glu Ala Leu Glu Lys Leu Gln Leu Asn Ile 
1               5                   10                  15      


Val Glu Met Lys Asp Glu Asn Ala Thr Leu Asp Gly Gly Asp Val Leu 
            20                  25                  30          


Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Arg Thr Asn Gln 
        35                  40                  45              


Arg Gly Ala Glu Ile Leu Ala Asp Thr Phe Lys Asp Tyr Ala Val Ser 
    50                  55                  60                  


Thr Val Pro Val Ala Asp Gly Leu His Leu Lys Ser Phe Cys Ser Met 
65                  70                  75                  80  


Ala Gly Pro Asn Leu Ile Ala Ile Gly Ser Ser Glu Ser Ala Gln Lys 
                85                  90                  95      


Ala Leu Lys Ile Met Gln Gln Met Ser Asp His Arg Tyr Asp Lys Leu 
            100                 105                 110         


Thr Val Pro Asp Asp Ile Ala Ala Asn Cys Ile Tyr Leu Asn Ile Pro 
        115                 120                 125             


Asn Lys Gly His Val Leu Leu His Arg Thr Pro Glu Glu Tyr Pro Glu 
    130                 135                 140                 


Ser Ala Lys Val Tyr Glu Lys Leu Lys Asp His Met Leu Ile Pro Val 
145                 150                 155                 160 


Ser Met Ser Glu Leu Glu Lys Val Asp Gly Leu Leu Thr Cys Cys Ser 
                165                 170                 175     


Val Leu Ile Asn Lys Lys Val Asp Ser 
            180                 185 


<210>  2936
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDAH2__Homo_sapiens__NP_001289937

<400>  2936

Met Gly Thr Pro Gly Glu Gly Leu Gly Arg Cys Ser His Ala Leu Ile 
1               5                   10                  15      


Arg Gly Val Pro Glu Ser Leu Ala Ser Gly Glu Gly Ala Gly Ala Gly 
            20                  25                  30          


Leu Pro Ala Leu Asp Leu Ala Lys Ala Gln Arg Glu His Gly Val Leu 
        35                  40                  45              


Gly Gly Lys Leu Arg Gln Arg Leu Gly Leu Gln Leu Leu Glu Leu Pro 
    50                  55                  60                  


Pro Glu Glu Ser Leu Pro Leu Gly Pro Leu Leu Gly Asp Thr Ala Val 
65                  70                  75                  80  


Ile Gln Gly Asp Thr Ala Leu Ile Thr Arg Pro Trp Ser Pro Ala Arg 
                85                  90                  95      


Arg Pro Glu Val Asp Gly Val Arg Lys Ala Leu Gln Asp Leu Gly Leu 
            100                 105                 110         


Arg Ile Val Glu Ile Gly Asp Glu Asn Ala Thr Leu Asp Gly Thr Asp 
        115                 120                 125             


Val Leu Phe Thr Gly Arg Glu Phe Phe Val Gly Leu Ser Lys Trp Thr 
    130                 135                 140                 


Asn His Arg Gly Ala Glu Ile Val Ala Asp Thr Phe Arg Asp Phe Ala 
145                 150                 155                 160 


Val Ser Thr Val Pro Val Ser Gly Pro Ser His Leu Arg Gly Leu Cys 
                165                 170                 175     


Gly Met Gly Gly Pro Arg Thr Val Val Ala Gly Ser Ser Asp Ala Ala 
            180                 185                 190         


Gln Lys Ala Val Arg Ala Met Ala Val Leu Thr Asp His Pro Tyr Ala 
        195                 200                 205             


Ser Leu Thr Leu Pro Asp Asp Ala Ala Ala Asp Cys Leu Phe Leu Arg 
    210                 215                 220                 


Pro Gly Leu Pro Gly Val Pro Pro Phe Leu Leu His Arg Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Pro Asn Ser Gln Glu Ala Leu Gln Lys Leu Ser Asp Val Thr 
                245                 250                 255     


Leu Val Pro Val Ser Cys Ser Glu Leu Glu Lys Ala Gly Ala Gly Leu 
            260                 265                 270         


Ser Ser Leu Cys Leu Val Leu Ser Thr Arg Pro His Ser 
        275                 280                 285 


<210>  2937
<211>  1140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDB1__Homo_sapiens__NP_001914

<400>  2937

Met Ser Tyr Asn Tyr Val Val Thr Ala Gln Lys Pro Thr Ala Val Asn 
1               5                   10                  15      


Gly Cys Val Thr Gly His Phe Thr Ser Ala Glu Asp Leu Asn Leu Leu 
            20                  25                  30          


Ile Ala Lys Asn Thr Arg Leu Glu Ile Tyr Val Val Thr Ala Glu Gly 
        35                  40                  45              


Leu Arg Pro Val Lys Glu Val Gly Met Tyr Gly Lys Ile Ala Val Met 
    50                  55                  60                  


Glu Leu Phe Arg Pro Lys Gly Glu Ser Lys Asp Leu Leu Phe Ile Leu 
65                  70                  75                  80  


Thr Ala Lys Tyr Asn Ala Cys Ile Leu Glu Tyr Lys Gln Ser Gly Glu 
                85                  90                  95      


Ser Ile Asp Ile Ile Thr Arg Ala His Gly Asn Val Gln Asp Arg Ile 
            100                 105                 110         


Gly Arg Pro Ser Glu Thr Gly Ile Ile Gly Ile Ile Asp Pro Glu Cys 
        115                 120                 125             


Arg Met Ile Gly Leu Arg Leu Tyr Asp Gly Leu Phe Lys Val Ile Pro 
    130                 135                 140                 


Leu Asp Arg Asp Asn Lys Glu Leu Lys Ala Phe Asn Ile Arg Leu Glu 
145                 150                 155                 160 


Glu Leu His Val Ile Asp Val Lys Phe Leu Tyr Gly Cys Gln Ala Pro 
                165                 170                 175     


Thr Ile Cys Phe Val Tyr Gln Asp Pro Gln Gly Arg His Val Lys Thr 
            180                 185                 190         


Tyr Glu Val Ser Leu Arg Glu Lys Glu Phe Asn Lys Gly Pro Trp Lys 
        195                 200                 205             


Gln Glu Asn Val Glu Ala Glu Ala Ser Met Val Ile Ala Val Pro Glu 
    210                 215                 220                 


Pro Phe Gly Gly Ala Ile Ile Ile Gly Gln Glu Ser Ile Thr Tyr His 
225                 230                 235                 240 


Asn Gly Asp Lys Tyr Leu Ala Ile Ala Pro Pro Ile Ile Lys Gln Ser 
                245                 250                 255     


Thr Ile Val Cys His Asn Arg Val Asp Pro Asn Gly Ser Arg Tyr Leu 
            260                 265                 270         


Leu Gly Asp Met Glu Gly Arg Leu Phe Met Leu Leu Leu Glu Lys Glu 
        275                 280                 285             


Glu Gln Met Asp Gly Thr Val Thr Leu Lys Asp Leu Arg Val Glu Leu 
    290                 295                 300                 


Leu Gly Glu Thr Ser Ile Ala Glu Cys Leu Thr Tyr Leu Asp Asn Gly 
305                 310                 315                 320 


Val Val Phe Val Gly Ser Arg Leu Gly Asp Ser Gln Leu Val Lys Leu 
                325                 330                 335     


Asn Val Asp Ser Asn Glu Gln Gly Ser Tyr Val Val Ala Met Glu Thr 
            340                 345                 350         


Phe Thr Asn Leu Gly Pro Ile Val Asp Met Cys Val Val Asp Leu Glu 
        355                 360                 365             


Arg Gln Gly Gln Gly Gln Leu Val Thr Cys Ser Gly Ala Phe Lys Glu 
    370                 375                 380                 


Gly Ser Leu Arg Ile Ile Arg Asn Gly Ile Gly Ile His Glu His Ala 
385                 390                 395                 400 


Ser Ile Asp Leu Pro Gly Ile Lys Gly Leu Trp Pro Leu Arg Ser Asp 
                405                 410                 415     


Pro Asn Arg Glu Thr Asp Asp Thr Leu Val Leu Ser Phe Val Gly Gln 
            420                 425                 430         


Thr Arg Val Leu Met Leu Asn Gly Glu Glu Val Glu Glu Thr Glu Leu 
        435                 440                 445             


Met Gly Phe Val Asp Asp Gln Gln Thr Phe Phe Cys Gly Asn Val Ala 
    450                 455                 460                 


His Gln Gln Leu Ile Gln Ile Thr Ser Ala Ser Val Arg Leu Val Ser 
465                 470                 475                 480 


Gln Glu Pro Lys Ala Leu Val Ser Glu Trp Lys Glu Pro Gln Ala Lys 
                485                 490                 495     


Asn Ile Ser Val Ala Ser Cys Asn Ser Ser Gln Val Val Val Ala Val 
            500                 505                 510         


Gly Arg Ala Leu Tyr Tyr Leu Gln Ile His Pro Gln Glu Leu Arg Gln 
        515                 520                 525             


Ile Ser His Thr Glu Met Glu His Glu Val Ala Cys Leu Asp Ile Thr 
    530                 535                 540                 


Pro Leu Gly Asp Ser Asn Gly Leu Ser Pro Leu Cys Ala Ile Gly Leu 
545                 550                 555                 560 


Trp Thr Asp Ile Ser Ala Arg Ile Leu Lys Leu Pro Ser Phe Glu Leu 
                565                 570                 575     


Leu His Lys Glu Met Leu Gly Gly Glu Ile Ile Pro Arg Ser Ile Leu 
            580                 585                 590         


Met Thr Thr Phe Glu Ser Ser His Tyr Leu Leu Cys Ala Leu Gly Asp 
        595                 600                 605             


Gly Ala Leu Phe Tyr Phe Gly Leu Asn Ile Glu Thr Gly Leu Leu Ser 
    610                 615                 620                 


Asp Arg Lys Lys Val Thr Leu Gly Thr Gln Pro Thr Val Leu Arg Thr 
625                 630                 635                 640 


Phe Arg Ser Leu Ser Thr Thr Asn Val Phe Ala Cys Ser Asp Arg Pro 
                645                 650                 655     


Thr Val Ile Tyr Ser Ser Asn His Lys Leu Val Phe Ser Asn Val Asn 
            660                 665                 670         


Leu Lys Glu Val Asn Tyr Met Cys Pro Leu Asn Ser Asp Gly Tyr Pro 
        675                 680                 685             


Asp Ser Leu Ala Leu Ala Asn Asn Ser Thr Leu Thr Ile Gly Thr Ile 
    690                 695                 700                 


Asp Glu Ile Gln Lys Leu His Ile Arg Thr Val Pro Leu Tyr Glu Ser 
705                 710                 715                 720 


Pro Arg Lys Ile Cys Tyr Gln Glu Val Ser Gln Cys Phe Gly Val Leu 
                725                 730                 735     


Ser Ser Arg Ile Glu Val Gln Asp Thr Ser Gly Gly Thr Thr Ala Leu 
            740                 745                 750         


Arg Pro Ser Ala Ser Thr Gln Ala Leu Ser Ser Ser Val Ser Ser Ser 
        755                 760                 765             


Lys Leu Phe Ser Ser Ser Thr Ala Pro His Glu Thr Ser Phe Gly Glu 
    770                 775                 780                 


Glu Val Glu Val His Asn Leu Leu Ile Ile Asp Gln His Thr Phe Glu 
785                 790                 795                 800 


Val Leu His Ala His Gln Phe Leu Gln Asn Glu Tyr Ala Leu Ser Leu 
                805                 810                 815     


Val Ser Cys Lys Leu Gly Lys Asp Pro Asn Thr Tyr Phe Ile Val Gly 
            820                 825                 830         


Thr Ala Met Val Tyr Pro Glu Glu Ala Glu Pro Lys Gln Gly Arg Ile 
        835                 840                 845             


Val Val Phe Gln Tyr Ser Asp Gly Lys Leu Gln Thr Val Ala Glu Lys 
    850                 855                 860                 


Glu Val Lys Gly Ala Val Tyr Ser Met Val Glu Phe Asn Gly Lys Leu 
865                 870                 875                 880 


Leu Ala Ser Ile Asn Ser Thr Val Arg Leu Tyr Glu Trp Thr Thr Glu 
                885                 890                 895     


Lys Glu Leu Arg Thr Glu Cys Asn His Tyr Asn Asn Ile Met Ala Leu 
            900                 905                 910         


Tyr Leu Lys Thr Lys Gly Asp Phe Ile Leu Val Gly Asp Leu Met Arg 
        915                 920                 925             


Ser Val Leu Leu Leu Ala Tyr Lys Pro Met Glu Gly Asn Phe Glu Glu 
    930                 935                 940                 


Ile Ala Arg Asp Phe Asn Pro Asn Trp Met Ser Ala Val Glu Ile Leu 
945                 950                 955                 960 


Asp Asp Asp Asn Phe Leu Gly Ala Glu Asn Ala Phe Asn Leu Phe Val 
                965                 970                 975     


Cys Gln Lys Asp Ser Ala Ala Thr Thr Asp Glu Glu Arg Gln His Leu 
            980                 985                 990         


Gln Glu Val Gly Leu Phe His Leu  Gly Glu Phe Val Asn  Val Phe Cys 
        995                 1000                 1005             


His Gly  Ser Leu Val Met Gln  Asn Leu Gly Glu Thr  Ser Thr Pro 
    1010                 1015                 1020             


Thr Gln  Gly Ser Val Leu Phe  Gly Thr Val Asn Gly  Met Ile Gly 
    1025                 1030                 1035             


Leu Val  Thr Ser Leu Ser Glu  Ser Trp Tyr Asn Leu  Leu Leu Asp 
    1040                 1045                 1050             


Met Gln  Asn Arg Leu Asn Lys  Val Ile Lys Ser Val  Gly Lys Ile 
    1055                 1060                 1065             


Glu His  Ser Phe Trp Arg Ser  Phe His Thr Glu Arg  Lys Thr Glu 
    1070                 1075                 1080             


Pro Ala  Thr Gly Phe Ile Asp  Gly Asp Leu Ile Glu  Ser Phe Leu 
    1085                 1090                 1095             


Asp Ile  Ser Arg Pro Lys Met  Gln Glu Val Val Ala  Asn Leu Gln 
    1100                 1105                 1110             


Tyr Asp  Asp Gly Ser Gly Met  Lys Arg Glu Ala Thr  Ala Asp Asp 
    1115                 1120                 1125             


Leu Ile  Lys Val Val Glu Glu  Leu Thr Arg Ile His  
    1130                 1135                 1140 


<210>  2938
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDB2__Homo_sapiens__NP_000098

<400>  2938

Met Ala Pro Lys Lys Arg Pro Glu Thr Gln Lys Thr Ser Glu Ile Val 
1               5                   10                  15      


Leu Arg Pro Arg Asn Lys Arg Ser Arg Ser Pro Leu Glu Leu Glu Pro 
            20                  25                  30          


Glu Ala Lys Lys Leu Cys Ala Lys Gly Ser Gly Pro Ser Arg Arg Cys 
        35                  40                  45              


Asp Ser Asp Cys Leu Trp Val Gly Leu Ala Gly Pro Gln Ile Leu Pro 
    50                  55                  60                  


Pro Cys Arg Ser Ile Val Arg Thr Leu His Gln His Lys Leu Gly Arg 
65                  70                  75                  80  


Ala Ser Trp Pro Ser Val Gln Gln Gly Leu Gln Gln Ser Phe Leu His 
                85                  90                  95      


Thr Leu Asp Ser Tyr Arg Ile Leu Gln Lys Ala Ala Pro Phe Asp Arg 
            100                 105                 110         


Arg Ala Thr Ser Leu Ala Trp His Pro Thr His Pro Ser Thr Val Ala 
        115                 120                 125             


Val Gly Ser Lys Gly Gly Asp Ile Met Leu Trp Asn Phe Gly Ile Lys 
    130                 135                 140                 


Asp Lys Pro Thr Phe Ile Lys Gly Ile Gly Ala Gly Gly Ser Ile Thr 
145                 150                 155                 160 


Gly Leu Lys Phe Asn Pro Leu Asn Thr Asn Gln Phe Tyr Ala Ser Ser 
                165                 170                 175     


Met Glu Gly Thr Thr Arg Leu Gln Asp Phe Lys Gly Asn Ile Leu Arg 
            180                 185                 190         


Val Phe Ala Ser Ser Asp Thr Ile Asn Ile Trp Phe Cys Ser Leu Asp 
        195                 200                 205             


Val Ser Ala Ser Ser Arg Met Val Val Thr Gly Asp Asn Val Gly Asn 
    210                 215                 220                 


Val Ile Leu Leu Asn Met Asp Gly Lys Glu Leu Trp Asn Leu Arg Met 
225                 230                 235                 240 


His Lys Lys Lys Val Thr His Val Ala Leu Asn Pro Cys Cys Asp Trp 
                245                 250                 255     


Phe Leu Ala Thr Ala Ser Val Asp Gln Thr Val Lys Ile Trp Asp Leu 
            260                 265                 270         


Arg Gln Val Arg Gly Lys Ala Ser Phe Leu Tyr Ser Leu Pro His Arg 
        275                 280                 285             


His Pro Val Asn Ala Ala Cys Phe Ser Pro Asp Gly Ala Arg Leu Leu 
    290                 295                 300                 


Thr Thr Asp Gln Lys Ser Glu Ile Arg Val Tyr Ser Ala Ser Gln Trp 
305                 310                 315                 320 


Asp Cys Pro Leu Gly Leu Ile Pro His Pro His Arg His Phe Gln His 
                325                 330                 335     


Leu Thr Pro Ile Lys Ala Ala Trp His Pro Arg Tyr Asn Leu Ile Val 
            340                 345                 350         


Val Gly Arg Tyr Pro Asp Pro Asn Phe Lys Ser Cys Thr Pro Tyr Glu 
        355                 360                 365             


Leu Arg Thr Ile Asp Val Phe Asp Gly Asn Ser Gly Lys Met Met Cys 
    370                 375                 380                 


Gln Leu Tyr Asp Pro Glu Ser Ser Gly Ile Ser Ser Leu Asn Glu Phe 
385                 390                 395                 400 


Asn Pro Met Gly Asp Thr Leu Ala Ser Ala Met Gly Tyr His Ile Leu 
                405                 410                 415     


Ile Trp Ser Gln Glu Glu Ala Arg Thr Arg Lys 
            420                 425         


<210>  2939
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDC__Homo_sapiens__NP_000781

<400>  2939

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Val Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  2940
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDHD1__Homo_sapiens__NP_001153619

<400>  2940

Met Asn Tyr Pro Gly Arg Gly Ser Pro Arg Ser Pro Glu His Asn Gly 
1               5                   10                  15      


Arg Gly Gly Gly Gly Gly Ala Trp Glu Leu Gly Ser Asp Ala Arg Pro 
            20                  25                  30          


Ala Phe Gly Gly Gly Val Cys Cys Phe Glu His Leu Pro Gly Gly Asp 
        35                  40                  45              


Pro Asp Asp Gly Asp Val Pro Leu Ala Leu Leu Arg Gly Glu Pro Gly 
    50                  55                  60                  


Leu His Leu Ala Pro Gly Thr Asp Asp His Asn His His Leu Ala Leu 
65                  70                  75                  80  


Asp Pro Cys Leu Ser Asp Glu Asn Tyr Asp Phe Ser Ser Ala Glu Ser 
                85                  90                  95      


Gly Ser Ser Leu Arg Tyr Tyr Ser Glu Gly Glu Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Ser Leu Ser Leu His Pro Pro Gln Gln Pro Pro Leu Val Pro Thr 
        115                 120                 125             


Asn Ser Gly Gly Gly Gly Ala Thr Gly Gly Ser Pro Gly Glu Arg Lys 
    130                 135                 140                 


Arg Thr Arg Leu Gly Gly Pro Ala Ala Arg His Arg Tyr Glu Val Val 
145                 150                 155                 160 


Thr Glu Leu Gly Pro Glu Glu Val Arg Trp Phe Tyr Lys Glu Asp Lys 
                165                 170                 175     


Lys Thr Trp Lys Pro Phe Ile Gly Tyr Asp Ser Leu Arg Ile Glu Leu 
            180                 185                 190         


Ala Phe Arg Thr Leu Leu Gln Thr Thr Gly Ala Arg Pro Gln Gly Gly 
        195                 200                 205             


Asp Arg Asp Gly Asp His Val Cys Ser Pro Thr Gly Pro Ala Ser Ser 
    210                 215                 220                 


Ser Gly Glu Asp Asp Asp Glu Asp Arg Ala Cys Gly Phe Cys Gln Ser 
225                 230                 235                 240 


Thr Thr Gly His Glu Pro Glu Met Val Glu Leu Val Asn Ile Glu Pro 
                245                 250                 255     


Val Cys Val Arg Gly Gly Leu Tyr Glu Val Asp Val Thr Gln Gly Glu 
            260                 265                 270         


Cys Tyr Pro Val Tyr Trp Asn Gln Ala Asp Lys Ile Pro Val Met Arg 
        275                 280                 285             


Gly Gln Trp Phe Ile Asp Gly Thr Trp Gln Pro Leu Glu Glu Glu Glu 
    290                 295                 300                 


Ser Asn Leu Ile Glu Gln Glu His Leu Asn Cys Phe Arg Gly Gln Gln 
305                 310                 315                 320 


Met Gln Glu Asn Phe Asp Ile Glu Val Ser Lys Ser Ile Asp Gly Lys 
                325                 330                 335     


Asp Gly Ser Gly Ile Asn Tyr Ser Ala Val His Ser Phe Lys Leu Ser 
            340                 345                 350         


Arg Asn His Val Asp Trp His Ser Val Asp Glu Val Tyr Leu Tyr Ser 
        355                 360                 365             


Asp Ala Thr Thr Ser Lys Ile Ala Arg Thr Val Thr Gln Lys Leu Gly 
    370                 375                 380                 


Phe Ser Lys Ala Ser Ser Ser Gly Thr Arg Leu His Arg Gly Tyr Val 
385                 390                 395                 400 


Glu Glu Ala Thr Leu Glu Asp Lys Pro Ser Gln Thr Thr His Ile Val 
                405                 410                 415     


Phe Val Val His Gly Ile Gly Gln Lys Met Asp Gln Gly Arg Ile Ile 
            420                 425                 430         


Lys Asn Thr Ala Met Met Arg Glu Ala Ala Arg Lys Ile Glu Glu Arg 
        435                 440                 445             


His Phe Ser Asn His Ala Thr His Val Glu Phe Leu Pro Val Glu Trp 
    450                 455                 460                 


Arg Ser Lys Leu Thr Leu Asp Gly Asp Thr Val Asp Ser Ile Thr Pro 
465                 470                 475                 480 


Asp Lys Val Arg Gly Leu Arg Asp Met Leu Asn Ser Ser Ala Met Asp 
                485                 490                 495     


Ile Met Tyr Tyr Thr Ser Pro Leu Tyr Arg Asp Glu Leu Val Lys Gly 
            500                 505                 510         


Leu Gln Gln Glu Leu Asn Arg Leu Tyr Ser Leu Phe Cys Ser Arg Asn 
        515                 520                 525             


Pro Asp Phe Glu Glu Lys Gly Gly Lys Val Ser Ile Val Ser His Ser 
    530                 535                 540                 


Leu Gly Cys Val Ile Thr Tyr Asp Ile Met Thr Gly Trp Asn Pro Val 
545                 550                 555                 560 


Arg Leu Tyr Glu Gln Leu Leu Gln Lys Glu Glu Glu Leu Pro Asp Glu 
                565                 570                 575     


Arg Trp Met Ser Tyr Glu Glu Arg His Leu Leu Asp Glu Leu Tyr Ile 
            580                 585                 590         


Thr Lys Arg Arg Leu Lys Glu Ile Glu Glu Arg Leu His Gly Leu Lys 
        595                 600                 605             


Ala Ser Ser Met Thr Gln Thr Pro Ala Leu Lys Phe Lys Val Glu Asn 
    610                 615                 620                 


Phe Phe Cys Met Gly Ser Pro Leu Ala Val Phe Leu Ala Leu Arg Gly 
625                 630                 635                 640 


Ile Arg Pro Gly Asn Thr Gly Ser Gln Asp His Ile Leu Pro Arg Glu 
                645                 650                 655     


Ile Cys Asn Arg Leu Leu Asn Ile Phe His Pro Thr Asp Pro Val Ala 
            660                 665                 670         


Tyr Arg Leu Glu Pro Leu Ile Leu Lys His Tyr Ser Asn Ile Ser Pro 
        675                 680                 685             


Val Gln Ile His Trp Tyr Asn Thr Ser Asn Pro Leu Pro Tyr Glu His 
    690                 695                 700                 


Met Lys Pro Ser Phe Leu Asn Pro Ala Lys Glu Pro Thr Ser Val Ser 
705                 710                 715                 720 


Glu Asn Glu Gly Ile Ser Thr Ile Pro Ser Pro Val Thr Ser Pro Val 
                725                 730                 735     


Leu Ser Arg Arg His Tyr Gly Glu Ser Ile Thr Asn Ile Gly Lys Ala 
            740                 745                 750         


Ser Ile Leu Gly Ala Ala Ser Ile Gly Lys Gly Leu Gly Gly Met Leu 
        755                 760                 765             


Phe Ser Arg Phe Gly Arg Ser Ser Thr Thr Gln Ser Ser Glu Thr Ser 
    770                 775                 780                 


Lys Asp Ser Met Glu Asp Glu Lys Lys Pro Val Ala Ser Pro Ser Ala 
785                 790                 795                 800 


Thr Thr Val Gly Thr Gln Thr Leu Pro His Ser Ser Ser Gly Phe Leu 
                805                 810                 815     


Asp Ser Ala Leu Glu Leu Asp His Arg Ile Asp Phe Glu Leu Arg Glu 
            820                 825                 830         


Gly Leu Val Glu Ser Arg Tyr Trp Ser Ala Val Thr Ser His Thr Ala 
        835                 840                 845             


Tyr Trp Ser Ser Leu Asp Val Ala Leu Phe Leu Leu Thr Phe Met Tyr 
    850                 855                 860                 


Lys His Glu His Asp Asp Asp Ala Lys Pro Asn Leu Asp Pro Ile 
865                 870                 875                 


<210>  2941
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDHD2__Homo_sapiens__NP_001157706

<400>  2941

Met Ser Ser Val Gln Ser Gln Gln Glu Gln Leu Ser Gln Ser Asp Pro 
1               5                   10                  15      


Ser Pro Ser Pro Asn Ser Cys Ser Ser Phe Glu Leu Ile Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Leu Tyr Glu Pro Val Ser Pro His Trp Phe Tyr Cys Lys 
        35                  40                  45              


Ile Ile Asp Ser Lys Glu Thr Trp Ile Pro Phe Asn Ser Glu Asp Ser 
    50                  55                  60                  


Gln Gln Leu Glu Glu Ala Tyr Ser Ser Gly Lys Gly Cys Asn Gly Arg 
65                  70                  75                  80  


Val Val Pro Thr Asp Gly Gly Arg Tyr Asp Val His Leu Gly Glu Arg 
                85                  90                  95      


Met Arg Tyr Ala Val Tyr Trp Asp Glu Leu Ala Ser Glu Val Arg Arg 
            100                 105                 110         


Cys Thr Trp Phe Tyr Lys Gly Asp Lys Asp Asn Lys Tyr Val Pro Tyr 
        115                 120                 125             


Ser Glu Ser Phe Ser Gln Val Leu Glu Glu Thr Tyr Met Leu Ala Val 
    130                 135                 140                 


Thr Leu Asp Glu Trp Lys Lys Lys Leu Glu Ser Pro Asn Arg Glu Ile 
145                 150                 155                 160 


Ile Ile Leu His Asn Pro Lys Leu Met Val His Tyr Gln Pro Val Ala 
                165                 170                 175     


Gly Ser Asp Asp Trp Gly Ser Thr Pro Thr Glu Gln Gly Arg Pro Arg 
            180                 185                 190         


Thr Val Lys Arg Gly Val Glu Asn Ile Ser Val Asp Ile His Cys Gly 
        195                 200                 205             


Asn Val Asn Arg Leu Phe Phe Leu Thr Phe Gly Cys Ile Cys Leu Leu 
    210                 215                 220                 


Leu Lys Leu 
225         


<210>  2942
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDI1__Homo_sapiens__NP_001001711

<400>  2942

Met Leu Ile Thr Val Tyr Cys Val Arg Arg Asp Leu Ser Glu Val Thr 
1               5                   10                  15      


Phe Ser Leu Gln Val Ser Pro Asp Phe Glu Leu Arg Asn Phe Lys Val 
            20                  25                  30          


Leu Cys Glu Ala Glu Ser Arg Val Pro Val Glu Glu Ile Gln Ile Ile 
        35                  40                  45              


His Met Glu Arg Leu Leu Ile Glu Asp His Cys Ser Leu Gly Ser Tyr 
    50                  55                  60                  


Gly Leu Lys Asp Gly Asp Ile Val Val Leu Leu Gln Lys Asp Asn Val 
65                  70                  75                  80  


Gly Pro Arg Ala Pro Gly Arg Ala Pro Asn Gln Pro Arg Val Asp Phe 
                85                  90                  95      


Ser Gly Ile Ala Val Pro Gly Thr Ser Ser Ser Arg Pro Gln His Pro 
            100                 105                 110         


Gly Gln Gln Gln Gln Arg Thr Pro Ala Ala Gln Arg Ser Gln Gly Leu 
        115                 120                 125             


Ala Ser Gly Glu Lys Val Ala Gly Leu Gln Gly Leu Gly Ser Pro Ala 
    130                 135                 140                 


Leu Ile Arg Ser Met Leu Leu Ser Asn Pro His Asp Leu Ser Leu Leu 
145                 150                 155                 160 


Lys Glu Arg Asn Pro Pro Leu Ala Glu Ala Leu Leu Ser Gly Ser Leu 
                165                 170                 175     


Glu Thr Phe Ser Gln Val Leu Met Glu Gln Gln Arg Glu Lys Ala Leu 
            180                 185                 190         


Arg Glu Gln Glu Arg Leu Arg Leu Tyr Thr Ala Asp Pro Leu Asp Arg 
        195                 200                 205             


Glu Ala Gln Ala Lys Ile Glu Glu Glu Ile Arg Gln Gln Asn Ile Glu 
    210                 215                 220                 


Glu Asn Met Asn Ile Ala Ile Glu Glu Ala Pro Glu Ser Phe Gly Gln 
225                 230                 235                 240 


Val Thr Met Leu Tyr Ile Asn Cys Lys Val Asn Gly His Pro Leu Lys 
                245                 250                 255     


Ala Phe Val Asp Ser Gly Ala Gln Met Thr Ile Met Ser Gln Ala Cys 
            260                 265                 270         


Ala Glu Arg Cys Asn Ile Met Arg Leu Val Asp Arg Arg Trp Ala Gly 
        275                 280                 285             


Val Ala Lys Gly Val Gly Thr Gln Arg Ile Ile Gly Arg Val His Leu 
    290                 295                 300                 


Ala Gln Ile Gln Ile Glu Gly Asp Phe Leu Gln Cys Ser Phe Ser Ile 
305                 310                 315                 320 


Leu Glu Asp Gln Pro Met Asp Met Leu Leu Gly Leu Asp Met Leu Arg 
                325                 330                 335     


Arg His Gln Cys Ser Ile Asp Leu Lys Lys Asn Val Leu Val Ile Gly 
            340                 345                 350         


Thr Thr Gly Thr Gln Thr Tyr Phe Leu Pro Glu Gly Glu Leu Pro Leu 
        355                 360                 365             


Cys Ser Arg Met Val Ser Gly Gln Asp Glu Ser Ser Asp Lys Glu Ile 
    370                 375                 380                 


Thr His Ser Val Met Asp Ser Gly Arg Lys Glu His 
385                 390                 395     


<210>  2943
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDIAS__Homo_sapiens__NP_659455

<400>  2943

Met Asn Arg Arg Arg Lys Phe Leu Leu Ala Ser Val Leu Ala Leu Gln 
1               5                   10                  15      


Asn Ser Ser Phe Ile Tyr Pro Ser Cys Gln Lys Cys Phe Ser Arg Ile 
            20                  25                  30          


Ile Leu Val Ser Lys Arg Ser Asn Cys Pro Lys Cys Gly Ser Thr Gly 
        35                  40                  45              


Glu Ser Gly Asn Ala Asn Tyr Arg Tyr Lys Leu Ser Leu Lys Val Ala 
    50                  55                  60                  


Glu Ser Asn Lys Leu Phe Val Ile Thr Val Phe Gly Ser Cys Leu Asp 
65                  70                  75                  80  


Thr Phe Phe Gly Leu Thr Ala Thr Gly Leu His Arg Tyr Ile Gln Asp 
                85                  90                  95      


Pro Asn Lys Ile Pro Glu Thr Leu Asp Asn Asp Thr Thr Gln Asn Leu 
            100                 105                 110         


Leu Thr Lys Ala Val Glu Thr Cys Phe Val Gly Gln Ser Phe Ile Phe 
        115                 120                 125             


Gly Val Thr Asn Phe Glu Asn Gln Pro Gly Gln Gly Ser Asp Ala Ser 
    130                 135                 140                 


Asn Phe Leu Gln Gln Cys Ser Asp His Lys Arg Lys Ala Lys Ala Leu 
145                 150                 155                 160 


Val Ala Cys Gln Ile Val Leu Pro Asp Pro Gly Ile Ala Gly Phe Thr 
                165                 170                 175     


Val Ile Asp Tyr Phe His Gln Leu Leu Gln Thr Phe Asn Phe Arg Lys 
            180                 185                 190         


Leu Gln Cys Asp Ser Gln Ala Pro Asn Asn His Leu Leu Ala Leu Asp 
        195                 200                 205             


His Ser Asn Ser Asp Leu Ser Ser Ile Tyr Thr Ser Asp Ser Thr Ser 
    210                 215                 220                 


Asp Phe Phe Lys Ser Cys Ser Lys Asp Thr Phe Ser Lys Phe Trp Gln 
225                 230                 235                 240 


Pro Ser Leu Glu Phe Thr Cys Ile Val Ser Gln Leu Thr Asp Asn Asp 
                245                 250                 255     


Asp Phe Ser Ala Ser Glu Gln Ser Lys Ala Phe Gly Thr Leu Gln Gln 
            260                 265                 270         


Asn Arg Lys Ser Ile Ser Ile Ala Glu Ala Thr Gly Ser Ser Ser Cys 
        275                 280                 285             


His Asp Pro Ile Gln Asp Ser Trp Ser Leu Val Ser Tyr Met Asp Lys 
    290                 295                 300                 


Lys Ser Thr Ala Glu Lys Leu Gly Lys Glu Leu Gly Leu Gln Ala Lys 
305                 310                 315                 320 


Glu Leu Ser Ala Val His Ser Ser His His Glu Ile Gly Val Asn Asp 
                325                 330                 335     


Ser Asn Leu Phe Ser Leu Glu Met Arg Glu Pro Leu Glu Ser Ser Asn 
            340                 345                 350         


Thr Lys Ser Phe His Ser Ala Val Glu Ile Lys Asn Arg Ser Gln His 
        355                 360                 365             


Glu Leu Pro Cys Phe Gln His His Gly Ile Asp Thr Pro Thr Ser Leu 
    370                 375                 380                 


Gln Lys Arg Ser Ala Cys Cys Pro Pro Ser Leu Leu Arg Leu Glu Glu 
385                 390                 395                 400 


Thr Ala Ser Ser Ser Gln Asp Gly Asp Pro Gln Ile Trp Asp Asp Leu 
                405                 410                 415     


Pro Phe Ser Glu Ser Leu Asn Lys Phe Leu Ala Val Leu Glu Ser Glu 
            420                 425                 430         


Ile Ala Val Thr Gln Ala Asp Val Ser Ser Arg Lys His His Val Asp 
        435                 440                 445             


Asn Asp Ile Asp Lys Phe His Ala Asp His Ser Arg Leu Ser Val Thr 
    450                 455                 460                 


Pro Gln Arg Thr Thr Gly Ala Leu His Thr Pro Pro Ile Ala Leu Arg 
465                 470                 475                 480 


Ser Ser Gln Val Ile Val Lys Ala Asn Cys Ser Lys Asp Asp Phe Leu 
                485                 490                 495     


Phe Asn Cys Lys Gly Asn Leu Ser Pro Ser Val Glu Lys Glu Ser Gln 
            500                 505                 510         


Pro Asp Asn Lys Val Glu Ala Val Ser Val Asn His Asn Gly Arg Asp 
        515                 520                 525             


Met Ser Glu Tyr Phe Leu Pro Asn Pro Tyr Leu Ser Ala Leu Ser Ser 
    530                 535                 540                 


Ser Ser Lys Asp Leu Glu Thr Ile Val Thr Leu Lys Lys Thr Ile Arg 
545                 550                 555                 560 


Ile Ser Pro His Arg Glu Ser Asp His Ser Ser Leu Asn Asn Lys Tyr 
                565                 570                 575     


Leu Asn Gly Cys Gly Glu Ile Ser Val Ser Glu Met Asn Glu Lys Leu 
            580                 585                 590         


Thr Thr Leu Cys Tyr Arg Lys Tyr Asn Asp Val Ser Asp Leu Cys Lys 
        595                 600                 605             


Leu Glu Asn Lys Gln Tyr Cys Arg Trp Ser Lys Asn Gln Asp Asp Ser 
    610                 615                 620                 


Phe Thr Ile Cys Arg Lys Leu Thr Tyr Pro Leu Glu Thr Leu Cys Asn 
625                 630                 635                 640 


Ser Pro Asn Arg Ser Thr Asn Thr Leu Lys Glu Met Pro Trp Gly His 
                645                 650                 655     


Ile Asn Asn Asn Val Thr Gln Ser Tyr Ser Ile Gly Tyr Glu Gly Ser 
            660                 665                 670         


Tyr Asp Ala Ser Ala Asp Leu Phe Asp Asp Ile Ala Lys Glu Met Asp 
        675                 680                 685             


Ile Ala Thr Glu Ile Thr Lys Lys Ser Gln Asp Ile Leu Leu Lys Trp 
    690                 695                 700                 


Gly Thr Ser Leu Ala Glu Ser His Pro Ser Glu Ser Asp Phe Ser Leu 
705                 710                 715                 720 


Arg Ser Leu Ser Glu Asp Phe Ile Gln Pro Ser Gln Lys Leu Ser Leu 
                725                 730                 735     


Gln Ser Leu Ser Asp Ser Arg His Ser Arg Thr Cys Ser Pro Thr Pro 
            740                 745                 750         


His Phe Gln Ser Asp Ser Glu Tyr Asn Phe Glu Asn Ser Gln Asp Phe 
        755                 760                 765             


Val Pro Cys Ser Gln Ser Thr Pro Ile Ser Gly Phe His Gln Thr Arg 
    770                 775                 780                 


Ile His Gly Ile Asn Arg Ala Phe Lys Lys Pro Val Phe Tyr Ser Asp 
785                 790                 795                 800 


Leu Asp Gly Asn Tyr Glu Lys Ile Arg Ile Phe Pro Glu Asn Asp Lys 
                805                 810                 815     


Gln Gln Ala Ser Pro Ser Cys Pro Lys Asn Ile Lys Thr Pro Ser Gln 
            820                 825                 830         


Lys Ile Arg Ser Pro Ile Val Ser Gly Val Ser Gln Pro Asp Val Phe 
        835                 840                 845             


Asn His Tyr Pro Phe Ala Glu Cys His Glu Thr Asp Ser Asp Glu Trp 
    850                 855                 860                 


Val Pro Pro Thr Thr Gln Lys Ile Phe Pro Ser Asp Met Leu Gly Phe 
865                 870                 875                 880 


Gln Gly Ile Gly Leu Gly Lys Cys Leu Ala Ala Tyr His Phe Pro Asp 
                885                 890                 895     


Gln Gln Glu Leu Pro Arg Lys Lys Leu Lys His Ile Arg Gln Gly Thr 
            900                 905                 910         


Asn Lys Gly Leu Ile Lys Lys Lys Leu Lys Asn Met Leu Ala Ala Val 
        915                 920                 925             


Val Thr Lys Lys Lys Thr His Lys Tyr Asn Cys Lys Ser Ser Gly Trp 
    930                 935                 940                 


Ile Ser Lys Cys Pro Asp Ile Gln Val Leu Ala Ala Pro Gln Leu His 
945                 950                 955                 960 


Pro Ile Leu Gly Pro Asp Ser Cys Ser Glu Val Lys Cys Cys Leu Pro 
                965                 970                 975     


Phe Ser Glu Lys Gly Pro Pro Ser Val Cys Glu Thr Arg Ser Ala Trp 
            980                 985                 990         


Ser Pro Glu Leu Phe Ser 
        995             


<210>  2944
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDIT3__Homo_sapiens__NP_001181983

<400>  2944

Met Glu Leu Val Pro Ala Thr Pro His Tyr Pro Ala Asp Val Leu Phe 
1               5                   10                  15      


Gln Thr Asp Pro Thr Ala Glu Met Ala Ala Glu Ser Leu Pro Phe Ser 
            20                  25                  30          


Phe Gly Thr Leu Ser Ser Trp Glu Leu Glu Ala Trp Tyr Glu Asp Leu 
        35                  40                  45              


Gln Glu Val Leu Ser Ser Asp Glu Asn Gly Gly Thr Tyr Val Ser Pro 
    50                  55                  60                  


Pro Gly Asn Glu Glu Glu Glu Ser Lys Ile Phe Thr Thr Leu Asp Pro 
65                  70                  75                  80  


Ala Ser Leu Ala Trp Leu Thr Glu Glu Glu Pro Glu Pro Ala Glu Val 
                85                  90                  95      


Thr Ser Thr Ser Gln Ser Pro His Ser Pro Asp Ser Ser Gln Ser Ser 
            100                 105                 110         


Leu Ala Gln Glu Glu Glu Glu Glu Asp Gln Gly Arg Thr Arg Lys Arg 
        115                 120                 125             


Lys Gln Ser Gly His Ser Pro Ala Arg Ala Gly Lys Gln Arg Met Lys 
    130                 135                 140                 


Glu Lys Glu Gln Glu Asn Glu Arg Lys Val Ala Gln Leu Ala Glu Glu 
145                 150                 155                 160 


Asn Glu Arg Leu Lys Gln Glu Ile Glu Arg Leu Thr Arg Glu Val Glu 
                165                 170                 175     


Ala Thr Arg Arg Ala Leu Ile Asp Arg Met Val Asn Leu His Gln Ala 
            180                 185                 190         


<210>  2945
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDIT4__Homo_sapiens__NP_061931

<400>  2945

Met Pro Ser Leu Trp Asp Arg Phe Ser Ser Ser Ser Thr Ser Ser Ser 
1               5                   10                  15      


Pro Ser Ser Leu Pro Arg Thr Pro Thr Pro Asp Arg Pro Pro Arg Ser 
            20                  25                  30          


Ala Trp Gly Ser Ala Thr Arg Glu Glu Gly Phe Asp Arg Ser Thr Ser 
        35                  40                  45              


Leu Glu Ser Ser Asp Cys Glu Ser Leu Asp Ser Ser Asn Ser Gly Phe 
    50                  55                  60                  


Gly Pro Glu Glu Asp Thr Ala Tyr Leu Asp Gly Val Ser Leu Pro Asp 
65                  70                  75                  80  


Phe Glu Leu Leu Ser Asp Pro Glu Asp Glu His Leu Cys Ala Asn Leu 
                85                  90                  95      


Met Gln Leu Leu Gln Glu Ser Leu Ala Gln Ala Arg Leu Gly Ser Arg 
            100                 105                 110         


Arg Pro Ala Arg Leu Leu Met Pro Ser Gln Leu Val Ser Gln Val Gly 
        115                 120                 125             


Lys Glu Leu Leu Arg Leu Ala Tyr Ser Glu Pro Cys Gly Leu Arg Gly 
    130                 135                 140                 


Ala Leu Leu Asp Val Cys Val Glu Gln Gly Lys Ser Cys His Ser Val 
145                 150                 155                 160 


Gly Gln Leu Ala Leu Asp Pro Ser Leu Val Pro Thr Phe Gln Leu Thr 
                165                 170                 175     


Leu Val Leu Arg Leu Asp Ser Arg Leu Trp Pro Lys Ile Gln Gly Leu 
            180                 185                 190         


Phe Ser Ser Ala Asn Ser Pro Phe Leu Pro Gly Phe Ser Gln Ser Leu 
        195                 200                 205             


Thr Leu Ser Thr Gly Phe Arg Val Ile Lys Lys Lys Leu Tyr Ser Ser 
    210                 215                 220                 


Glu Gln Leu Leu Ile Glu Glu Cys 
225                 230         


<210>  2946
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDIT4L__Homo_sapiens__NP_660287

<400>  2946

Met Val Ala Thr Gly Ser Leu Ser Ser Lys Asn Pro Ala Ser Ile Ser 
1               5                   10                  15      


Glu Leu Leu Asp Cys Gly Tyr His Pro Glu Ser Leu Leu Ser Asp Phe 
            20                  25                  30          


Asp Tyr Trp Asp Tyr Val Val Pro Glu Pro Asn Leu Asn Glu Val Ile 
        35                  40                  45              


Phe Glu Glu Ser Thr Cys Gln Asn Leu Val Lys Met Leu Glu Asn Cys 
    50                  55                  60                  


Leu Ser Lys Ser Lys Gln Thr Lys Leu Gly Cys Ser Lys Val Leu Val 
65                  70                  75                  80  


Pro Glu Lys Leu Thr Gln Arg Ile Ala Gln Asp Val Leu Arg Leu Ser 
                85                  90                  95      


Ser Thr Glu Pro Cys Gly Leu Arg Gly Cys Val Met His Val Asn Leu 
            100                 105                 110         


Glu Ile Glu Asn Val Cys Lys Lys Leu Asp Arg Ile Val Cys Asp Ser 
        115                 120                 125             


Ser Val Val Pro Thr Phe Glu Leu Thr Leu Val Phe Lys Gln Glu Asn 
    130                 135                 140                 


Cys Ser Trp Thr Ser Phe Arg Asp Phe Phe Phe Ser Arg Gly Arg Phe 
145                 150                 155                 160 


Ser Ser Gly Phe Arg Arg Thr Leu Ile Leu Ser Ser Gly Phe Arg Leu 
                165                 170                 175     


Val Lys Lys Lys Leu Tyr Ser Leu Ile Gly Thr Thr Val Ile Glu Gly 
            180                 185                 190         


Ser 
    


<210>  2947
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDN__Homo_sapiens__NP_055901

<400>  2947

Met Leu Asp Gly Pro Leu Phe Ser Glu Gly Pro Asp Ser Pro Arg Glu 
1               5                   10                  15      


Leu Gln Asp Glu Glu Ser Gly Ser Cys Leu Trp Val Gln Lys Ser Lys 
            20                  25                  30          


Leu Leu Val Ile Glu Val Lys Thr Ile Ser Cys His Tyr Ser Arg Arg 
        35                  40                  45              


Ala Pro Ser Arg Gln Pro Met Asp Phe Gln Ala Ser His Trp Ala Arg 
    50                  55                  60                  


Gly Phe Gln Asn Arg Thr Cys Gly Pro Arg Pro Gly Ser Pro Gln Pro 
65                  70                  75                  80  


Pro Pro Arg Arg Pro Trp Ala Ser Arg Val Leu Gln Glu Ala Thr Asn 
                85                  90                  95      


Trp Arg Ala Gly Pro Leu Ala Glu Val Arg Ala Arg Glu Gln Glu Lys 
            100                 105                 110         


Arg Lys Ala Ala Ser Gln Glu Arg Glu Ala Lys Glu Thr Glu Arg Lys 
        115                 120                 125             


Arg Arg Lys Ala Gly Gly Ala Arg Arg Ser Pro Pro Gly Arg Pro Arg 
    130                 135                 140                 


Pro Glu Pro Arg Asn Ala Pro Arg Val Ala Gln Leu Ala Gly Leu Pro 
145                 150                 155                 160 


Ala Pro Leu Arg Pro Glu Arg Leu Ala Pro Val Gly Arg Ala Pro Arg 
                165                 170                 175     


Pro Ser Ala Gln Pro Gln Ser Asp Pro Gly Ser Ala Trp Ala Gly Pro 
            180                 185                 190         


Trp Gly Gly Arg Arg Pro Gly Pro Pro Ser Tyr Glu Ala His Leu Leu 
        195                 200                 205             


Leu Arg Gly Ser Ala Gly Thr Ala Pro Arg Arg Arg Trp Asp Arg Pro 
    210                 215                 220                 


Pro Pro Tyr Val Ala Pro Pro Ser Tyr Glu Gly Pro His Arg Thr Leu 
225                 230                 235                 240 


Gly Thr Lys Arg Gly Pro Gly Asn Ser Gln Val Pro Thr Ser Ser Ala 
                245                 250                 255     


Pro Ala Ala Thr Pro Ala Arg Thr Asp Gly Gly Arg Thr Lys Lys Arg 
            260                 265                 270         


Leu Asp Pro Arg Ile Tyr Arg Asp Val Leu Gly Ala Trp Gly Leu Arg 
        275                 280                 285             


Gln Gly Gln Gly Leu Leu Gly Gly Ser Pro Gly Cys Gly Ala Ala Arg 
    290                 295                 300                 


Ala Arg Pro Glu Pro Gly Lys Gly Val Val Glu Lys Ser Leu Gly Leu 
305                 310                 315                 320 


Ala Ala Ala Asp Leu Asn Ser Gly Ser Asp Ser His Pro Gln Ala Lys 
                325                 330                 335     


Ala Thr Gly Ser Ala Gly Thr Glu Ile Ala Pro Ala Gly Ser Ala Thr 
            340                 345                 350         


Ala Ala Pro Cys Ala Pro His Pro Ala Pro Arg Ser Arg His His Leu 
        355                 360                 365             


Lys Gly Ser Arg Glu Gly Lys Glu Gly Glu Gln Ile Trp Phe Pro Lys 
    370                 375                 380                 


Cys Trp Ile Pro Ser Pro Lys Lys Gln Pro Pro Arg His Ser Gln Thr 
385                 390                 395                 400 


Leu Pro Arg Pro Trp Ala Pro Gly Gly Thr Gly Trp Arg Glu Ser Leu 
                405                 410                 415     


Gly Leu Gly Glu Gly Ala Gly Pro Glu Thr Leu Glu Gly Trp Lys Ala 
            420                 425                 430         


Thr Arg Arg Ala His Thr Leu Pro Arg Ser Ser Gln Gly Leu Ser Arg 
        435                 440                 445             


Gly Glu Gly Val Phe Val Ile Asp Ala Thr Cys Val Val Ile Arg Ser 
    450                 455                 460                 


Gln Tyr Val Pro Thr Pro Arg Thr Gln Gln Val Gln Leu Leu Pro Ser 
465                 470                 475                 480 


Gly Val Thr Arg Val Val Gly Asp Ser Pro Ser Gln Ser Lys Pro Gly 
                485                 490                 495     


Lys Glu Glu Gly Glu Gly Ala Thr Val Phe Pro Ser Pro Cys Gln Lys 
            500                 505                 510         


Arg Leu Ser Ser Ser Arg Leu Leu His Gln Pro Gly Gly Gly Arg Gly 
        515                 520                 525             


Gly Glu Ala Glu Gly Gly Arg Pro Gly Asp Ser Thr Leu Glu Glu Arg 
    530                 535                 540                 


Thr Phe Arg Ile Leu Gly Leu Pro Ala Pro Glu Val Asn Leu Arg Asp 
545                 550                 555                 560 


Ala Pro Thr Gln Pro Gly Ser Pro Glu His Gln Ala Leu Gly Pro Ala 
                565                 570                 575     


Ala Ser Gly Ala Gln Gly Arg Ala Glu Gly Ser Glu Val Ala Val Val 
            580                 585                 590         


Gln Arg Arg Ala Gly Arg Gly Trp Ala Arg Thr Pro Gly Pro Tyr Ala 
        595                 600                 605             


Gly Ala Leu Arg Glu Ala Val Ser Arg Ile Arg Arg His Thr Ala Pro 
    610                 615                 620                 


Asp Ser Asp Thr Asp Glu Ala Glu Glu Leu Ser Val His Ser Gly Ser 
625                 630                 635                 640 


Ser Asp Gly Ser Asp Thr Glu Ala Pro Gly Ala Ser Trp Arg Asn Glu 
                645                 650                 655     


Arg Thr Leu Pro Glu Val Gly Asn Ser Ser Pro Glu Glu Asp Gly Lys 
            660                 665                 670         


Thr Ala Glu Leu Ser Asp Ser Val Gly Glu Ile Leu Asp Val Ile Ser 
        675                 680                 685             


Gln Thr Glu Glu Val Leu Phe Gly Val Arg Asp Ile Arg Gly Thr Gln 
    690                 695                 700                 


Gln Gly Asn Arg Lys Arg Gln 
705                 710     


<210>  2948
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDO__Homo_sapiens__NP_003640

<400>  2948

Met Arg Pro Ala Arg His Trp Glu Thr Arg Phe Gly Ala Arg Asp Phe 
1               5                   10                  15      


Gly Gly Phe Gln Asp Cys Phe Phe Arg Asp Arg Leu Met Asp Thr Ala 
            20                  25                  30          


Arg Ile Ala Val Val Gly Ala Gly Val Val Gly Leu Ser Thr Ala Val 
        35                  40                  45              


Cys Ile Ser Lys Leu Val Pro Arg Cys Ser Val Thr Ile Ile Ser Asp 
    50                  55                  60                  


Lys Phe Thr Pro Asp Thr Thr Ser Asp Val Ala Ala Gly Met Leu Ile 
65                  70                  75                  80  


Pro His Thr Tyr Pro Asp Thr Pro Ile His Thr Gln Lys Gln Trp Phe 
                85                  90                  95      


Arg Glu Thr Phe Asn His Leu Phe Ala Ile Ala Asn Ser Ala Glu Ala 
            100                 105                 110         


Gly Asp Ala Gly Val His Leu Val Ser Gly Trp Gln Ile Phe Gln Ser 
        115                 120                 125             


Thr Pro Thr Glu Glu Val Pro Phe Trp Ala Asp Val Val Leu Gly Phe 
    130                 135                 140                 


Arg Lys Met Thr Glu Ala Glu Leu Lys Lys Phe Pro Gln Tyr Val Phe 
145                 150                 155                 160 


Gly Gln Ala Phe Thr Thr Leu Lys Cys Glu Cys Pro Ala Tyr Leu Pro 
                165                 170                 175     


Trp Leu Glu Lys Arg Ile Lys Gly Ser Gly Gly Trp Thr Leu Thr Arg 
            180                 185                 190         


Arg Ile Glu Asp Leu Trp Glu Leu His Pro Ser Phe Asp Ile Val Val 
        195                 200                 205             


Asn Cys Ser Gly Leu Gly Ser Arg Gln Leu Ala Gly Asp Ser Lys Ile 
    210                 215                 220                 


Phe Pro Val Arg Gly Gln Val Leu Gln Val Gln Ala Pro Trp Val Glu 
225                 230                 235                 240 


His Phe Ile Arg Asp Gly Ser Gly Leu Thr Tyr Ile Tyr Pro Gly Thr 
                245                 250                 255     


Ser His Val Thr Leu Gly Gly Thr Arg Gln Lys Gly Asp Trp Asn Leu 
            260                 265                 270         


Ser Pro Asp Ala Glu Asn Ser Arg Glu Ile Leu Ser Arg Cys Cys Ala 
        275                 280                 285             


Leu Glu Pro Ser Leu His Gly Ala Cys Asn Ile Arg Glu Lys Val Gly 
    290                 295                 300                 


Leu Arg Pro Tyr Arg Pro Gly Val Arg Leu Gln Thr Glu Leu Leu Ala 
305                 310                 315                 320 


Arg Asp Gly Gln Arg Leu Pro Val Val His His Tyr Gly His Gly Ser 
                325                 330                 335     


Gly Gly Ile Ser Val His Trp Gly Thr Ala Leu Glu Ala Ala Arg Leu 
            340                 345                 350         


Val Ser Glu Cys Val His Ala Leu Arg Thr Pro Ile Pro Lys Ser Asn 
        355                 360                 365             


Leu 
    


<210>  2949
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDR1__Homo_sapiens__NP_001189450

<400>  2949

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Gly Ala Pro Val 
            500                 505             


<210>  2950
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDR2__Homo_sapiens__XP_011507889

<400>  2950

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  2951
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDRGK1__Homo_sapiens__NP_076424

<400>  2951

Met Val Ala Pro Val Trp Tyr Leu Val Ala Ala Ala Leu Leu Val Gly 
1               5                   10                  15      


Phe Ile Leu Phe Leu Thr Arg Ser Arg Gly Arg Ala Ala Ser Ala Gly 
            20                  25                  30          


Gln Glu Pro Leu His Asn Glu Glu Leu Ala Gly Ala Gly Arg Val Ala 
        35                  40                  45              


Gln Pro Gly Pro Leu Glu Pro Glu Glu Pro Arg Ala Gly Gly Arg Pro 
    50                  55                  60                  


Arg Arg Arg Arg Asp Leu Gly Ser Arg Leu Gln Ala Gln Arg Arg Ala 
65                  70                  75                  80  


Gln Arg Val Ala Trp Ala Glu Ala Asp Glu Asn Glu Glu Glu Ala Val 
                85                  90                  95      


Ile Leu Ala Gln Glu Glu Glu Gly Val Glu Lys Pro Ala Glu Thr His 
            100                 105                 110         


Leu Ser Gly Lys Ile Gly Ala Lys Lys Leu Arg Lys Leu Glu Glu Lys 
        115                 120                 125             


Gln Ala Arg Lys Ala Gln Arg Glu Ala Glu Glu Ala Glu Arg Glu Glu 
    130                 135                 140                 


Arg Lys Arg Leu Glu Ser Gln Arg Glu Ala Glu Trp Lys Lys Glu Glu 
145                 150                 155                 160 


Glu Arg Leu Arg Leu Glu Glu Glu Gln Lys Glu Glu Glu Glu Arg Lys 
                165                 170                 175     


Ala Arg Glu Glu Gln Ala Gln Arg Glu His Glu Glu Tyr Leu Lys Leu 
            180                 185                 190         


Lys Glu Ala Phe Val Val Glu Glu Glu Gly Val Gly Glu Thr Met Thr 
        195                 200                 205             


Glu Glu Gln Ser Gln Ser Phe Leu Thr Glu Phe Ile Asn Tyr Ile Lys 
    210                 215                 220                 


Gln Ser Lys Val Val Leu Leu Glu Asp Leu Ala Ser Gln Val Gly Leu 
225                 230                 235                 240 


Arg Thr Gln Asp Thr Ile Asn Arg Ile Gln Asp Leu Leu Ala Glu Gly 
                245                 250                 255     


Thr Ile Thr Gly Val Ile Asp Asp Arg Gly Lys Phe Ile Tyr Ile Thr 
            260                 265                 270         


Pro Glu Glu Leu Ala Ala Val Ala Asn Phe Ile Arg Gln Arg Gly Arg 
        275                 280                 285             


Val Ser Ile Ala Glu Leu Ala Gln Ala Ser Asn Ser Leu Ile Ala Trp 
    290                 295                 300                 


Gly Arg Glu Ser Pro Ala Gln Ala Pro Ala 
305                 310                 


<210>  2952
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDT__Homo_sapiens__NP_001077861

<400>  2952

Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro 
1               5                   10                  15      


Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly 
            20                  25                  30          


Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met 
        35                  40                  45              


Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser 
    50                  55                  60                  


Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His 
65                  70                  75                  80  


Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Ile 
                85                  90                  95      


Leu Ile Arg Phe Phe Pro Leu Glu Ser Trp Gln Ile Gly Lys Ile Gly 
            100                 105                 110         


Thr Val Met Thr Phe Leu 
        115             


<210>  2953
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDTL__Homo_sapiens__NP_001077862

<400>  2953

Met Pro Phe Leu Glu Leu Asp Thr Asn Leu Pro Ala Asn Arg Val Pro 
1               5                   10                  15      


Ala Gly Leu Glu Lys Arg Leu Cys Ala Ala Ala Ala Ser Ile Leu Gly 
            20                  25                  30          


Lys Pro Ala Asp Arg Val Asn Val Thr Val Arg Pro Gly Leu Ala Met 
        35                  40                  45              


Ala Leu Ser Gly Ser Thr Glu Pro Cys Ala Gln Leu Ser Ile Ser Ser 
    50                  55                  60                  


Ile Gly Val Val Gly Thr Ala Glu Asp Asn Arg Ser His Ser Ala His 
65                  70                  75                  80  


Phe Phe Glu Phe Leu Thr Lys Glu Leu Ala Leu Gly Gln Asp Arg Phe 
                85                  90                  95      


Pro Thr Val Leu Ser Thr Ser Pro Ala Ala His Gly Gly Pro Arg Cys 
            100                 105                 110         


Pro Gly Glu Ile Ile Glu Gly Lys Lys Ser Cys Leu Asn Glu Glu Ala 
        115                 120                 125             


Leu Phe Ile Tyr Phe Ile 
    130                 


<210>  2954
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX10__Homo_sapiens__NP_004389

<400>  2954

Met Gly Lys Thr Ala Asn Ser Pro Gly Ser Gly Ala Arg Pro Asp Pro 
1               5                   10                  15      


Val Arg Ser Phe Asn Arg Trp Lys Lys Lys His Ser His Arg Gln Asn 
            20                  25                  30          


Lys Lys Lys Gln Leu Arg Lys Gln Leu Lys Lys Pro Glu Trp Gln Val 
        35                  40                  45              


Glu Arg Glu Ser Ile Ser Arg Leu Met Gln Asn Tyr Glu Lys Ile Asn 
    50                  55                  60                  


Val Asn Glu Ile Thr Arg Phe Ser Asp Phe Pro Leu Ser Lys Lys Thr 
65                  70                  75                  80  


Leu Lys Gly Leu Gln Glu Ala Gln Tyr Arg Leu Val Thr Glu Ile Gln 
                85                  90                  95      


Lys Gln Thr Ile Gly Leu Ala Leu Gln Gly Lys Asp Val Leu Gly Ala 
            100                 105                 110         


Ala Lys Thr Gly Ser Gly Lys Thr Leu Ala Phe Leu Val Pro Val Leu 
        115                 120                 125             


Glu Ala Leu Tyr Arg Leu Gln Trp Thr Ser Thr Asp Gly Leu Gly Val 
    130                 135                 140                 


Leu Ile Ile Ser Pro Thr Arg Glu Leu Ala Tyr Gln Thr Phe Glu Val 
145                 150                 155                 160 


Leu Arg Lys Val Gly Lys Asn His Asp Phe Ser Ala Gly Leu Ile Ile 
                165                 170                 175     


Gly Gly Lys Asp Leu Lys His Glu Ala Glu Arg Ile Asn Asn Ile Asn 
            180                 185                 190         


Ile Leu Val Cys Thr Pro Gly Arg Leu Leu Gln His Met Asp Glu Thr 
        195                 200                 205             


Val Ser Phe His Ala Thr Asp Leu Gln Met Leu Val Leu Asp Glu Ala 
    210                 215                 220                 


Asp Arg Ile Leu Asp Met Gly Phe Ala Asp Thr Met Asn Ala Val Ile 
225                 230                 235                 240 


Glu Asn Leu Pro Lys Lys Arg Gln Thr Leu Leu Phe Ser Ala Thr Gln 
                245                 250                 255     


Thr Lys Ser Val Lys Asp Leu Ala Arg Leu Ser Leu Lys Asn Pro Glu 
            260                 265                 270         


Tyr Val Trp Val His Glu Lys Ala Lys Tyr Ser Thr Pro Ala Thr Leu 
        275                 280                 285             


Glu Gln Asn Tyr Ile Val Cys Glu Leu Gln Gln Lys Ile Ser Val Leu 
    290                 295                 300                 


Tyr Ser Phe Leu Arg Ser His Leu Lys Lys Lys Ser Ile Val Phe Phe 
305                 310                 315                 320 


Ser Ser Cys Lys Glu Val Gln Tyr Leu Tyr Arg Val Phe Cys Arg Leu 
                325                 330                 335     


Arg Pro Gly Val Ser Ile Leu Ala Leu His Gly Arg Gln Gln Gln Met 
            340                 345                 350         


Arg Arg Met Glu Val Tyr Asn Glu Phe Val Arg Lys Arg Ala Ala Val 
        355                 360                 365             


Leu Phe Ala Thr Asp Ile Ala Ala Arg Gly Leu Asp Phe Pro Ala Val 
    370                 375                 380                 


Asn Trp Val Leu Gln Phe Asp Cys Pro Glu Asp Ala Asn Thr Tyr Ile 
385                 390                 395                 400 


His Arg Ala Gly Arg Thr Ala Arg Tyr Lys Glu Asp Gly Glu Ala Leu 
                405                 410                 415     


Leu Ile Leu Leu Pro Ser Glu Lys Ala Met Val Gln Gln Leu Leu Gln 
            420                 425                 430         


Lys Lys Val Pro Val Lys Glu Ile Lys Ile Asn Pro Glu Lys Leu Ile 
        435                 440                 445             


Asp Val Gln Lys Lys Leu Glu Ser Ile Leu Ala Gln Asp Gln Asp Leu 
    450                 455                 460                 


Lys Glu Arg Ala Gln Arg Cys Phe Val Ser Tyr Val Arg Ser Val Tyr 
465                 470                 475                 480 


Leu Met Lys Asp Lys Glu Val Phe Asp Val Ser Lys Leu Pro Ile Pro 
                485                 490                 495     


Glu Tyr Ala Leu Ser Leu Gly Leu Ala Val Ala Pro Arg Val Arg Phe 
            500                 505                 510         


Leu Gln Lys Met Gln Lys Gln Pro Thr Lys Glu Leu Val Arg Ser Gln 
        515                 520                 525             


Ala Asp Lys Val Ile Glu Pro Arg Ala Pro Ser Leu Thr Asn Asp Glu 
    530                 535                 540                 


Val Glu Glu Phe Arg Ala Tyr Phe Asn Glu Lys Met Ser Ile Leu Gln 
545                 550                 555                 560 


Lys Gly Gly Lys Arg Leu Glu Gly Thr Glu His Arg Gln Asp Asn Asp 
                565                 570                 575     


Thr Gly Asn Glu Glu Gln Glu Glu Glu Glu Asp Asp Glu Glu Glu Met 
            580                 585                 590         


Glu Glu Lys Leu Ala Lys Ala Lys Gly Ser Gln Ala Pro Ser Leu Pro 
        595                 600                 605             


Asn Thr Ser Glu Ala Gln Lys Ile Lys Glu Val Pro Thr Gln Phe Leu 
    610                 615                 620                 


Asp Arg Asp Glu Glu Glu Glu Asp Ala Asp Phe Leu Lys Val Lys Arg 
625                 630                 635                 640 


His Asn Val Phe Gly Leu Asp Leu Lys Asp Glu Lys Thr Leu Gln Lys 
                645                 650                 655     


Lys Glu Pro Ser Lys Ser Ser Ile Lys Lys Lys Met Thr Lys Val Ala 
            660                 665                 670         


Glu Ala Lys Lys Val Met Lys Arg Asn Phe Lys Val Asn Lys Lys Ile 
        675                 680                 685             


Thr Phe Thr Asp Glu Gly Glu Leu Val Gln Gln Trp Pro Gln Met Gln 
    690                 695                 700                 


Lys Ser Ala Ile Lys Asp Ala Glu Glu Asp Asp Asp Thr Gly Gly Ile 
705                 710                 715                 720 


Asn Leu His Lys Ala Lys Glu Arg Leu Gln Glu Glu Asp Lys Phe Asp 
                725                 730                 735     


Lys Glu Glu Tyr Arg Lys Lys Ile Lys Ala Lys His Arg Glu Lys Arg 
            740                 745                 750         


Leu Lys Glu Arg Glu Ala Arg Arg Glu Ala Asn Lys Arg Gln Ala Lys 
        755                 760                 765             


Ala Lys Asp Glu Glu Glu Ala Phe Leu Asp Trp Ser Asp Asp Asp Asp 
    770                 775                 780                 


Asp Asp Asp Asp Gly Phe Asp Pro Ser Thr Leu Pro Asp Pro Asp Lys 
785                 790                 795                 800 


Tyr Arg Ser Ser Glu Asp Ser Asp Ser Glu Asp Met Glu Asn Lys Ile 
                805                 810                 815     


Ser Asp Thr Lys Lys Lys Gln Gly Met Lys Lys Arg Ser Asn Ser Glu 
            820                 825                 830         


Val Glu Asp Val Gly Pro Thr Ser His Asn Arg Lys Lys Ala Arg Trp 
        835                 840                 845             


Asp Thr Leu Glu Pro Leu Asp Thr Gly Leu Ser Leu Ala Glu Asp Glu 
    850                 855                 860                 


Glu Leu Val Leu His Leu Leu Arg Ser Gln Ser 
865                 870                 875 


<210>  2955
<211>  880
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX11__Homo_sapiens__NP_001244074

<400>  2955

Met Ala Glu Leu Tyr Arg Val Leu Glu Ala Gly Lys Ile Gly Ile Phe 
1               5                   10                  15      


Glu Ser Pro Thr Gly Thr Gly Lys Ser Leu Ser Leu Ile Cys Gly Ala 
            20                  25                  30          


Leu Ser Trp Leu Arg Asp Phe Glu Gln Lys Lys Arg Glu Glu Glu Ala 
        35                  40                  45              


Arg Leu Leu Glu Thr Gly Thr Gly Pro Leu His Asp Glu Lys Asp Glu 
    50                  55                  60                  


Ser Leu Cys Leu Ser Ser Ser Cys Glu Gly Ala Ala Gly Thr Pro Arg 
65                  70                  75                  80  


Pro Ala Gly Glu Pro Ala Trp Val Thr Gln Phe Val Gln Lys Lys Glu 
                85                  90                  95      


Glu Arg Asp Leu Val Asp Arg Leu Lys Ala Glu Gln Ala Arg Arg Lys 
            100                 105                 110         


Gln Arg Glu Glu Arg Leu Gln Gln Leu Gln His Arg Val Gln Leu Lys 
        115                 120                 125             


Tyr Ala Ala Lys Arg Leu Arg Gln Glu Glu Glu Glu Arg Glu Asn Leu 
    130                 135                 140                 


Leu Arg Leu Ser Arg Glu Met Leu Glu Thr Gly Pro Glu Ala Glu Arg 
145                 150                 155                 160 


Leu Glu Gln Leu Glu Ser Gly Glu Glu Glu Leu Val Leu Ala Glu Tyr 
                165                 170                 175     


Glu Ser Asp Glu Glu Lys Lys Val Ala Ser Arg Val Asp Glu Asp Glu 
            180                 185                 190         


Asp Asp Leu Glu Glu Glu His Ile Thr Lys Ile Tyr Tyr Cys Ser Arg 
        195                 200                 205             


Thr His Ser Gln Leu Ala Gln Phe Val His Glu Val Lys Lys Ser Pro 
    210                 215                 220                 


Phe Gly Lys Asp Val Arg Leu Val Ser Leu Gly Ser Arg Gln Asn Leu 
225                 230                 235                 240 


Cys Val Asn Glu Asp Val Lys Ser Leu Gly Ser Val Gln Leu Ile Asn 
                245                 250                 255     


Asp Arg Cys Val Asp Met Gln Arg Ser Arg His Glu Lys Lys Lys Gly 
            260                 265                 270         


Ala Glu Glu Glu Lys Pro Lys Arg Arg Arg Gln Glu Lys Gln Ala Ala 
        275                 280                 285             


Cys Pro Phe Tyr Asn His Glu Gln Met Gly Leu Leu Arg Asp Glu Ala 
    290                 295                 300                 


Leu Ala Glu Val Lys Asp Met Glu Gln Leu Leu Ala Leu Gly Lys Glu 
305                 310                 315                 320 


Ala Arg Ala Cys Pro Tyr Tyr Gly Ser Arg Leu Ala Ile Pro Ala Ala 
                325                 330                 335     


Gln Leu Val Val Leu Pro Tyr Gln Met Leu Leu His Ala Ala Thr Arg 
            340                 345                 350         


Gln Ala Ala Gly Ile Arg Leu Gln Asp Gln Val Val Ile Ile Asp Glu 
        355                 360                 365             


Ala His Asn Leu Ile Asp Thr Ile Thr Gly Met His Ser Val Glu Val 
    370                 375                 380                 


Ser Gly Ser Gln Leu Cys Gln Ala His Ser Gln Leu Leu Gln Tyr Val 
385                 390                 395                 400 


Glu Arg Tyr Gly Lys Arg Leu Lys Ala Lys Asn Leu Met Tyr Leu Lys 
                405                 410                 415     


Gln Ile Leu Tyr Leu Leu Glu Lys Phe Val Ala Val Leu Gly Gly Asn 
            420                 425                 430         


Ile Lys Gln Asn Pro Asn Thr Gln Ser Leu Ser Gln Thr Gly Thr Glu 
        435                 440                 445             


Leu Lys Thr Ile Asn Asp Phe Leu Phe Gln Ser Gln Ile Asp Asn Ile 
    450                 455                 460                 


Asn Leu Phe Lys Val Gln Arg Tyr Cys Glu Lys Ser Met Ile Ser Arg 
465                 470                 475                 480 


Lys Leu Phe Gly Phe Thr Glu Arg Tyr Gly Ala Val Phe Ser Ser Arg 
                485                 490                 495     


Glu Gln Pro Lys Leu Ala Gly Phe Gln Gln Phe Leu Gln Ser Leu Gln 
            500                 505                 510         


Pro Arg Thr Thr Glu Ala Leu Ala Ala Pro Ala Asp Glu Ser Gln Ala 
        515                 520                 525             


Ser Thr Leu Arg Pro Ala Ser Pro Leu Met His Ile Gln Gly Phe Leu 
    530                 535                 540                 


Ala Ala Leu Thr Thr Ala Asn Gln Asp Gly Arg Val Ile Leu Ser Arg 
545                 550                 555                 560 


Gln Gly Ser Leu Ser Gln Ser Thr Leu Lys Phe Leu Leu Leu Asn Pro 
                565                 570                 575     


Ala Val His Phe Ala Gln Val Val Lys Glu Cys Arg Ala Val Val Ile 
            580                 585                 590         


Ala Gly Gly Thr Met Gln Pro Val Ser Asp Phe Arg Gln Gln Leu Leu 
        595                 600                 605             


Ala Cys Ala Gly Val Glu Ala Glu Arg Val Val Glu Phe Ser Cys Gly 
    610                 615                 620                 


His Val Ile Pro Pro Asp Asn Ile Leu Pro Leu Val Ile Cys Ser Gly 
625                 630                 635                 640 


Ile Ser Asn Gln Pro Leu Glu Phe Thr Phe Gln Lys Arg Glu Leu Pro 
                645                 650                 655     


Gln Met Met Asp Glu Val Gly Arg Ile Leu Cys Asn Leu Cys Gly Val 
            660                 665                 670         


Val Pro Gly Gly Val Val Cys Phe Phe Pro Ser Tyr Glu Tyr Leu Arg 
        675                 680                 685             


Gln Val His Ala His Trp Glu Lys Gly Gly Leu Leu Gly Arg Leu Ala 
    690                 695                 700                 


Ala Arg Lys Lys Ile Phe Gln Glu Pro Lys Ser Ala His Gln Val Glu 
705                 710                 715                 720 


Gln Val Leu Leu Ala Tyr Ser Arg Cys Ile Gln Ala Cys Gly Gln Glu 
                725                 730                 735     


Arg Gly Gln Val Thr Gly Ala Leu Leu Leu Ser Val Val Gly Gly Lys 
            740                 745                 750         


Met Ser Glu Gly Ile Asn Phe Ser Asp Asn Leu Gly Arg Cys Val Val 
        755                 760                 765             


Met Val Gly Met Pro Phe Pro Asn Ile Arg Ser Ala Glu Leu Gln Glu 
    770                 775                 780                 


Lys Met Ala Tyr Leu Asp Gln Thr Leu Pro Arg Ala Pro Gly Gln Ala 
785                 790                 795                 800 


Pro Pro Gly Lys Ala Leu Val Glu Asn Leu Cys Met Lys Ala Val Asn 
                805                 810                 815     


Gln Ser Ile Gly Arg Ala Ile Arg His Gln Lys Asp Phe Ala Ser Val 
            820                 825                 830         


Val Leu Leu Asp Gln Arg Tyr Ala Arg Pro Pro Val Leu Ala Lys Leu 
        835                 840                 845             


Pro Ala Trp Ile Arg Ala Arg Val Glu Val Lys Ala Thr Phe Gly Pro 
    850                 855                 860                 


Ala Ile Ala Ala Val Gln Lys Phe His Arg Glu Lys Ser Ala Ser Ser 
865                 870                 875                 880 


<210>  2956
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX17__Homo_sapiens__NP_001091974

<400>  2956

Met Pro Thr Gly Phe Val Ala Pro Ile Leu Cys Val Leu Leu Pro Ser 
1               5                   10                  15      


Pro Thr Arg Glu Ala Ala Thr Val Ala Ser Ala Thr Gly Asp Ser Ala 
            20                  25                  30          


Ser Glu Arg Glu Ser Ala Ala Pro Ala Ala Ala Pro Thr Ala Glu Ala 
        35                  40                  45              


Pro Pro Pro Ser Val Val Thr Arg Pro Glu Pro Gln Ala Leu Pro Ser 
    50                  55                  60                  


Pro Ala Ile Arg Ala Pro Leu Pro Asp Leu Tyr Pro Phe Gly Thr Met 
65                  70                  75                  80  


Arg Gly Gly Gly Phe Gly Asp Arg Asp Arg Asp Arg Asp Arg Gly Gly 
                85                  90                  95      


Phe Gly Ala Arg Gly Gly Gly Gly Leu Pro Pro Lys Lys Phe Gly Asn 
            100                 105                 110         


Pro Gly Glu Arg Leu Arg Lys Lys Lys Trp Asp Leu Ser Glu Leu Pro 
        115                 120                 125             


Lys Phe Glu Lys Asn Phe Tyr Val Glu His Pro Glu Val Ala Arg Leu 
    130                 135                 140                 


Thr Pro Tyr Glu Val Asp Glu Leu Arg Arg Lys Lys Glu Ile Thr Val 
145                 150                 155                 160 


Arg Gly Gly Asp Val Cys Pro Lys Pro Val Phe Ala Phe His His Ala 
                165                 170                 175     


Asn Phe Pro Gln Tyr Val Met Asp Val Leu Met Asp Gln His Phe Thr 
            180                 185                 190         


Glu Pro Thr Pro Ile Gln Cys Gln Gly Phe Pro Leu Ala Leu Ser Gly 
        195                 200                 205             


Arg Asp Met Val Gly Ile Ala Gln Thr Gly Ser Gly Lys Thr Leu Ala 
    210                 215                 220                 


Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Tyr Leu Glu 
225                 230                 235                 240 


Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu 
                245                 250                 255     


Ala Gln Gln Val Gln Gln Val Ala Asp Asp Tyr Gly Lys Cys Ser Arg 
            260                 265                 270         


Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile 
        275                 280                 285             


Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg 
    290                 295                 300                 


Leu Ile Asp Phe Leu Glu Ser Gly Lys Thr Asn Leu Arg Arg Cys Thr 
305                 310                 315                 320 


Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu 
                325                 330                 335     


Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr 
            340                 345                 350         


Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu 
        355                 360                 365             


Asp Phe Leu Arg Asp Tyr Thr Gln Ile Asn Val Gly Asn Leu Glu Leu 
    370                 375                 380                 


Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys Met Glu Ser 
385                 390                 395                 400 


Glu Lys Asp His Lys Leu Ile Gln Leu Met Glu Glu Ile Met Ala Glu 
                405                 410                 415     


Lys Glu Asn Lys Thr Ile Ile Phe Val Glu Thr Lys Arg Arg Cys Asp 
            420                 425                 430         


Asp Leu Thr Arg Arg Met Arg Arg Asp Gly Trp Pro Ala Met Cys Ile 
        435                 440                 445             


His Gly Asp Lys Ser Gln Pro Glu Arg Asp Trp Val Leu Asn Glu Phe 
    450                 455                 460                 


Arg Ser Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg 
465                 470                 475                 480 


Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro 
                485                 490                 495     


Asn Ser Ser Glu Asp Tyr Val His Arg Ile Gly Arg Thr Ala Arg Ser 
            500                 505                 510         


Thr Asn Lys Gly Thr Ala Tyr Thr Phe Phe Thr Pro Gly Asn Leu Lys 
        515                 520                 525             


Gln Ala Arg Glu Leu Ile Lys Val Leu Glu Glu Ala Asn Gln Ala Ile 
    530                 535                 540                 


Asn Pro Lys Leu Met Gln Leu Val Asp His Arg Gly Gly Gly Gly Gly 
545                 550                 555                 560 


Gly Gly Lys Gly Gly Arg Ser Arg Tyr Arg Thr Thr Ser Ser Ala Asn 
                565                 570                 575     


Asn Pro Asn Leu Met Tyr Gln Asp Glu Cys Asp Arg Arg Leu Arg Gly 
            580                 585                 590         


Val Lys Asp Gly Gly Arg Arg Asp Ser Ala Ser Tyr Arg Asp Arg Ser 
        595                 600                 605             


Glu Thr Asp Arg Ala Gly Tyr Ala Asn Gly Ser Gly Tyr Gly Ser Pro 
    610                 615                 620                 


Asn Ser Ala Phe Gly Ala Gln Ala Gly Gln Tyr Thr Tyr Gly Gln Gly 
625                 630                 635                 640 


Thr Tyr Gly Ala Ala Ala Tyr Gly Thr Ser Ser Tyr Thr Ala Gln Glu 
                645                 650                 655     


Tyr Gly Ala Gly Thr Tyr Gly Ala Ser Ser Thr Thr Ser Thr Gly Arg 
            660                 665                 670         


Ser Ser Gln Ser Ser Ser Gln Gln Phe Ser Gly Ile Gly Arg Ser Gly 
        675                 680                 685             


Gln Gln Pro Gln Pro Leu Met Ser Gln Gln Phe Ala Gln Pro Pro Gly 
    690                 695                 700                 


Ala Thr Asn Met Ile Gly Tyr Met Gly Gln Thr Ala Tyr Gln Tyr Pro 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Pro Pro Pro Ser Arg Lys 
                725                 730     


<210>  2957
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX18__Homo_sapiens__NP_006764

<400>  2957

Met Ser His Leu Pro Met Lys Leu Leu Arg Lys Lys Ile Glu Lys Arg 
1               5                   10                  15      


Asn Leu Lys Leu Arg Gln Arg Asn Leu Lys Phe Gln Gly Ala Ser Asn 
            20                  25                  30          


Leu Thr Leu Ser Glu Thr Gln Asn Gly Asp Val Ser Glu Glu Thr Met 
        35                  40                  45              


Gly Ser Arg Lys Val Lys Lys Ser Lys Gln Lys Pro Met Asn Val Gly 
    50                  55                  60                  


Leu Ser Glu Thr Gln Asn Gly Gly Met Ser Gln Glu Ala Val Gly Asn 
65                  70                  75                  80  


Ile Lys Val Thr Lys Ser Pro Gln Lys Ser Thr Val Leu Thr Asn Gly 
                85                  90                  95      


Glu Ala Ala Met Gln Ser Ser Asn Ser Glu Ser Lys Lys Lys Lys Lys 
            100                 105                 110         


Lys Lys Arg Lys Met Val Asn Asp Ala Glu Pro Asp Thr Lys Lys Ala 
        115                 120                 125             


Lys Thr Glu Asn Lys Gly Lys Ser Glu Glu Glu Ser Ala Glu Thr Thr 
    130                 135                 140                 


Lys Glu Thr Glu Asn Asn Val Glu Lys Pro Asp Asn Asp Glu Asp Glu 
145                 150                 155                 160 


Ser Glu Val Pro Ser Leu Pro Leu Gly Leu Thr Gly Ala Phe Glu Asp 
                165                 170                 175     


Thr Ser Phe Ala Ser Leu Cys Asn Leu Val Asn Glu Asn Thr Leu Lys 
            180                 185                 190         


Ala Ile Lys Glu Met Gly Phe Thr Asn Met Thr Glu Ile Gln His Lys 
        195                 200                 205             


Ser Ile Arg Pro Leu Leu Glu Gly Arg Asp Leu Leu Ala Ala Ala Lys 
    210                 215                 220                 


Thr Gly Ser Gly Lys Thr Leu Ala Phe Leu Ile Pro Ala Val Glu Leu 
225                 230                 235                 240 


Ile Val Lys Leu Arg Phe Met Pro Arg Asn Gly Thr Gly Val Leu Ile 
                245                 250                 255     


Leu Ser Pro Thr Arg Glu Leu Ala Met Gln Thr Phe Gly Val Leu Lys 
            260                 265                 270         


Glu Leu Met Thr His His Val His Thr Tyr Gly Leu Ile Met Gly Gly 
        275                 280                 285             


Ser Asn Arg Ser Ala Glu Ala Gln Lys Leu Gly Asn Gly Ile Asn Ile 
    290                 295                 300                 


Ile Val Ala Thr Pro Gly Arg Leu Leu Asp His Met Gln Asn Thr Pro 
305                 310                 315                 320 


Gly Phe Met Tyr Lys Asn Leu Gln Cys Leu Val Ile Asp Glu Ala Asp 
                325                 330                 335     


Arg Ile Leu Asp Val Gly Phe Glu Glu Glu Leu Lys Gln Ile Ile Lys 
            340                 345                 350         


Leu Leu Pro Thr Arg Arg Gln Thr Met Leu Phe Ser Ala Thr Gln Thr 
        355                 360                 365             


Arg Lys Val Glu Asp Leu Ala Arg Ile Ser Leu Lys Lys Glu Pro Leu 
    370                 375                 380                 


Tyr Val Gly Val Asp Asp Asp Lys Ala Asn Ala Thr Val Asp Gly Leu 
385                 390                 395                 400 


Glu Gln Gly Tyr Val Val Cys Pro Ser Glu Lys Arg Phe Leu Leu Leu 
                405                 410                 415     


Phe Thr Phe Leu Lys Lys Asn Arg Lys Lys Lys Leu Met Val Phe Phe 
            420                 425                 430         


Ser Ser Cys Met Ser Val Lys Tyr His Tyr Glu Leu Leu Asn Tyr Ile 
        435                 440                 445             


Asp Leu Pro Val Leu Ala Ile His Gly Lys Gln Lys Gln Asn Lys Arg 
    450                 455                 460                 


Thr Thr Thr Phe Phe Gln Phe Cys Asn Ala Asp Ser Gly Thr Leu Leu 
465                 470                 475                 480 


Cys Thr Asp Val Ala Ala Arg Gly Leu Asp Ile Pro Glu Val Asp Trp 
                485                 490                 495     


Ile Val Gln Tyr Asp Pro Pro Asp Asp Pro Lys Glu Tyr Ile His Arg 
            500                 505                 510         


Val Gly Arg Thr Ala Arg Gly Leu Asn Gly Arg Gly His Ala Leu Leu 
        515                 520                 525             


Ile Leu Arg Pro Glu Glu Leu Gly Phe Leu Arg Tyr Leu Lys Gln Ser 
    530                 535                 540                 


Lys Val Pro Leu Ser Glu Phe Asp Phe Ser Trp Ser Lys Ile Ser Asp 
545                 550                 555                 560 


Ile Gln Ser Gln Leu Glu Lys Leu Ile Glu Lys Asn Tyr Phe Leu His 
                565                 570                 575     


Lys Ser Ala Gln Glu Ala Tyr Lys Ser Tyr Ile Arg Ala Tyr Asp Ser 
            580                 585                 590         


His Ser Leu Lys Gln Ile Phe Asn Val Asn Asn Leu Asn Leu Pro Gln 
        595                 600                 605             


Val Ala Leu Ser Phe Gly Phe Lys Val Pro Pro Phe Val Asp Leu Asn 
    610                 615                 620                 


Val Asn Ser Asn Glu Gly Lys Gln Lys Lys Arg Gly Gly Gly Gly Gly 
625                 630                 635                 640 


Phe Gly Tyr Gln Lys Thr Lys Lys Val Glu Lys Ser Lys Ile Phe Lys 
                645                 650                 655     


His Ile Ser Lys Lys Ser Ser Asp Ser Arg Gln Phe Ser His 
            660                 665                 670 


<210>  2958
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX19A__Homo_sapiens__NP_060802

<400>  2958

Met Ala Thr Asp Ser Trp Ala Leu Ala Val Asp Glu Gln Glu Ala Ala 
1               5                   10                  15      


Val Lys Ser Met Thr Asn Leu Gln Ile Lys Glu Glu Lys Val Lys Ala 
            20                  25                  30          


Asp Thr Asn Gly Ile Ile Lys Thr Ser Thr Thr Ala Glu Lys Thr Asp 
        35                  40                  45              


Glu Glu Glu Lys Glu Asp Arg Ala Ala Gln Ser Leu Leu Asn Lys Leu 
    50                  55                  60                  


Ile Arg Ser Asn Leu Val Asp Asn Thr Asn Gln Val Glu Val Leu Gln 
65                  70                  75                  80  


Arg Asp Pro Asn Ser Pro Leu Tyr Ser Val Lys Ser Phe Glu Glu Leu 
                85                  90                  95      


Arg Leu Lys Pro Gln Leu Leu Gln Gly Val Tyr Ala Met Gly Phe Asn 
            100                 105                 110         


Arg Pro Ser Lys Ile Gln Glu Asn Ala Leu Pro Met Met Leu Ala Glu 
        115                 120                 125             


Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln Ser Gly Thr Gly Lys Thr 
    130                 135                 140                 


Ala Ala Phe Val Leu Ala Met Leu Ser Arg Val Glu Pro Ser Asp Arg 
145                 150                 155                 160 


Tyr Pro Gln Cys Leu Cys Leu Ser Pro Thr Tyr Glu Leu Ala Leu Gln 
                165                 170                 175     


Thr Gly Lys Val Ile Glu Gln Met Gly Lys Phe Tyr Pro Glu Leu Lys 
            180                 185                 190         


Leu Ala Tyr Ala Val Arg Gly Asn Lys Leu Glu Arg Gly Gln Lys Ile 
        195                 200                 205             


Ser Glu Gln Ile Val Ile Gly Thr Pro Gly Thr Val Leu Asp Trp Cys 
    210                 215                 220                 


Ser Lys Leu Lys Phe Ile Asp Pro Lys Lys Ile Lys Val Phe Val Leu 
225                 230                 235                 240 


Asp Glu Ala Asp Val Met Ile Ala Thr Gln Gly His Gln Asp Gln Ser 
                245                 250                 255     


Ile Arg Ile Gln Arg Met Leu Pro Arg Asn Cys Gln Met Leu Leu Phe 
            260                 265                 270         


Ser Ala Thr Phe Glu Asp Ser Val Trp Lys Phe Ala Gln Lys Val Val 
        275                 280                 285             


Pro Asp Pro Asn Val Ile Lys Leu Lys Arg Glu Glu Glu Thr Leu Asp 
    290                 295                 300                 


Thr Ile Lys Gln Tyr Tyr Val Leu Cys Ser Ser Arg Asp Glu Lys Phe 
305                 310                 315                 320 


Gln Ala Leu Cys Asn Leu Tyr Gly Ala Ile Thr Ile Ala Gln Ala Met 
                325                 330                 335     


Ile Phe Cys His Thr Arg Lys Thr Ala Ser Trp Leu Ala Ala Glu Leu 
            340                 345                 350         


Ser Lys Glu Gly His Gln Val Ala Leu Leu Ser Gly Glu Met Met Val 
        355                 360                 365             


Glu Gln Arg Ala Ala Val Ile Glu Arg Phe Arg Glu Gly Lys Glu Lys 
    370                 375                 380                 


Val Leu Val Thr Thr Asn Val Cys Ala Arg Gly Ile Asp Val Glu Gln 
385                 390                 395                 400 


Val Ser Val Val Ile Asn Phe Asp Leu Pro Val Asp Lys Asp Gly Asn 
                405                 410                 415     


Pro Asp Asn Glu Thr Tyr Leu His Arg Ile Gly Arg Thr Gly Arg Phe 
            420                 425                 430         


Gly Lys Arg Gly Leu Ala Val Asn Met Val Asp Ser Lys His Ser Met 
        435                 440                 445             


Asn Ile Leu Asn Arg Ile Gln Glu His Phe Asn Lys Lys Ile Glu Arg 
    450                 455                 460                 


Leu Asp Thr Asp Asp Leu Asp Glu Ile Glu Lys Ile Ala Asn 
465                 470                 475             


<210>  2959
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX1__Homo_sapiens__NP_004930

<400>  2959

Met Ala Ala Phe Ser Glu Met Gly Val Met Pro Glu Ile Ala Gln Ala 
1               5                   10                  15      


Val Glu Glu Met Asp Trp Leu Leu Pro Thr Asp Ile Gln Ala Glu Ser 
            20                  25                  30          


Ile Pro Leu Ile Leu Gly Gly Gly Asp Val Leu Met Ala Ala Glu Thr 
        35                  40                  45              


Gly Ser Gly Lys Thr Gly Ala Phe Ser Ile Pro Val Ile Gln Ile Val 
    50                  55                  60                  


Tyr Glu Thr Leu Lys Asp Gln Gln Glu Gly Lys Lys Gly Lys Thr Thr 
65                  70                  75                  80  


Ile Lys Thr Gly Ala Ser Val Leu Asn Lys Trp Gln Met Asn Pro Tyr 
                85                  90                  95      


Asp Arg Gly Ser Ala Phe Ala Ile Gly Ser Asp Gly Leu Cys Cys Gln 
            100                 105                 110         


Ser Arg Glu Val Lys Glu Trp His Gly Cys Arg Ala Thr Lys Gly Leu 
        115                 120                 125             


Met Lys Gly Lys His Tyr Tyr Glu Val Ser Cys His Asp Gln Gly Leu 
    130                 135                 140                 


Cys Arg Val Gly Trp Ser Thr Met Gln Ala Ser Leu Asp Leu Gly Thr 
145                 150                 155                 160 


Asp Lys Phe Gly Phe Gly Phe Gly Gly Thr Gly Lys Lys Ser His Asn 
                165                 170                 175     


Lys Gln Phe Asp Asn Tyr Gly Glu Glu Phe Thr Met His Asp Thr Ile 
            180                 185                 190         


Gly Cys Tyr Leu Asp Ile Asp Lys Gly His Val Lys Phe Ser Lys Asn 
        195                 200                 205             


Gly Lys Asp Leu Gly Leu Ala Phe Glu Ile Pro Pro His Met Lys Asn 
    210                 215                 220                 


Gln Ala Leu Phe Pro Ala Cys Val Leu Lys Asn Ala Glu Leu Lys Phe 
225                 230                 235                 240 


Asn Phe Gly Glu Glu Glu Phe Lys Phe Pro Pro Lys Asp Gly Phe Val 
                245                 250                 255     


Ala Leu Ser Lys Ala Pro Asp Gly Tyr Ile Val Lys Ser Gln His Ser 
            260                 265                 270         


Gly Asn Ala Gln Val Thr Gln Thr Lys Phe Leu Pro Asn Ala Pro Lys 
        275                 280                 285             


Ala Leu Ile Val Glu Pro Ser Arg Glu Leu Ala Glu Gln Thr Leu Asn 
    290                 295                 300                 


Asn Ile Lys Gln Phe Lys Lys Tyr Ile Asp Asn Pro Lys Leu Arg Glu 
305                 310                 315                 320 


Leu Leu Ile Ile Gly Gly Val Ala Ala Arg Asp Gln Leu Ser Val Leu 
                325                 330                 335     


Glu Asn Gly Val Asp Ile Val Val Gly Thr Pro Gly Arg Leu Asp Asp 
            340                 345                 350         


Leu Val Ser Thr Gly Lys Leu Asn Leu Ser Gln Val Arg Phe Leu Val 
        355                 360                 365             


Leu Asp Glu Ala Asp Gly Leu Leu Ser Gln Gly Tyr Ser Asp Phe Ile 
    370                 375                 380                 


Asn Arg Met His Asn Gln Ile Pro Gln Val Thr Ser Asp Gly Lys Arg 
385                 390                 395                 400 


Leu Gln Val Ile Val Cys Ser Ala Thr Leu His Ser Phe Asp Val Lys 
                405                 410                 415     


Lys Leu Ser Glu Lys Ile Met His Phe Pro Thr Trp Val Asp Leu Lys 
            420                 425                 430         


Gly Glu Asp Ser Val Pro Asp Thr Val His His Val Val Val Pro Val 
        435                 440                 445             


Asn Pro Lys Thr Asp Arg Leu Trp Glu Arg Leu Gly Lys Ser His Ile 
    450                 455                 460                 


Arg Thr Asp Asp Val His Ala Lys Asp Asn Thr Arg Pro Gly Ala Asn 
465                 470                 475                 480 


Ser Pro Glu Met Trp Ser Glu Ala Ile Lys Ile Leu Lys Gly Glu Tyr 
                485                 490                 495     


Ala Val Arg Ala Ile Lys Glu His Lys Met Asp Gln Ala Ile Ile Phe 
            500                 505                 510         


Cys Arg Thr Lys Ile Asp Cys Asp Asn Leu Glu Gln Tyr Phe Ile Gln 
        515                 520                 525             


Gln Gly Gly Gly Pro Asp Lys Lys Gly His Gln Phe Ser Cys Val Cys 
    530                 535                 540                 


Leu His Gly Asp Arg Lys Pro His Glu Arg Lys Gln Asn Leu Glu Arg 
545                 550                 555                 560 


Phe Lys Lys Gly Asp Val Arg Phe Leu Ile Cys Thr Asp Val Ala Ala 
                565                 570                 575     


Arg Gly Ile Asp Ile His Gly Val Pro Tyr Val Ile Asn Val Thr Leu 
            580                 585                 590         


Pro Asp Glu Lys Gln Asn Tyr Val His Arg Ile Gly Arg Val Gly Arg 
        595                 600                 605             


Ala Glu Arg Met Gly Leu Ala Ile Ser Leu Val Ala Thr Glu Lys Glu 
    610                 615                 620                 


Lys Val Trp Tyr His Val Cys Ser Ser Arg Gly Lys Gly Cys Tyr Asn 
625                 630                 635                 640 


Thr Arg Leu Lys Glu Asp Gly Gly Cys Thr Ile Trp Tyr Asn Glu Met 
                645                 650                 655     


Gln Leu Leu Ser Glu Ile Glu Glu His Leu Asn Cys Thr Ile Ser Gln 
            660                 665                 670         


Val Glu Pro Asp Ile Lys Val Pro Val Asp Glu Phe Asp Gly Lys Val 
        675                 680                 685             


Thr Tyr Gly Gln Lys Arg Ala Ala Gly Gly Gly Ser Tyr Lys Gly His 
    690                 695                 700                 


Val Asp Ile Leu Ala Pro Thr Val Gln Glu Leu Ala Ala Leu Glu Lys 
705                 710                 715                 720 


Glu Ala Gln Thr Ser Phe Leu His Leu Gly Tyr Leu Pro Asn Gln Leu 
                725                 730                 735     


Phe Arg Thr Phe 
            740 


<210>  2960
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX21__Homo_sapiens__NP_004719

<400>  2960

Met Pro Gly Lys Leu Arg Ser Asp Ala Gly Leu Glu Ser Asp Thr Ala 
1               5                   10                  15      


Met Lys Lys Gly Glu Thr Leu Arg Lys Gln Thr Glu Glu Lys Glu Lys 
            20                  25                  30          


Lys Glu Lys Pro Lys Ser Asp Lys Thr Glu Glu Ile Ala Glu Glu Glu 
        35                  40                  45              


Glu Thr Val Phe Pro Lys Ala Lys Gln Val Lys Lys Lys Ala Glu Pro 
    50                  55                  60                  


Ser Glu Val Asp Met Asn Ser Pro Lys Ser Lys Lys Ala Lys Lys Lys 
65                  70                  75                  80  


Glu Glu Pro Ser Gln Asn Asp Ile Ser Pro Lys Thr Lys Ser Leu Arg 
                85                  90                  95      


Lys Lys Lys Glu Pro Ile Glu Lys Lys Val Val Ser Ser Lys Thr Lys 
            100                 105                 110         


Lys Val Thr Lys Asn Glu Glu Pro Ser Glu Glu Glu Ile Asp Ala Pro 
        115                 120                 125             


Lys Pro Lys Lys Met Lys Lys Glu Lys Glu Met Asn Gly Glu Thr Arg 
    130                 135                 140                 


Glu Lys Ser Pro Lys Leu Lys Asn Gly Phe Pro His Pro Glu Pro Asp 
145                 150                 155                 160 


Cys Asn Pro Ser Glu Ala Ala Ser Glu Glu Ser Asn Ser Glu Ile Glu 
                165                 170                 175     


Gln Glu Ile Pro Val Glu Gln Lys Glu Gly Ala Phe Ser Asn Phe Pro 
            180                 185                 190         


Ile Ser Glu Glu Thr Ile Lys Leu Leu Lys Gly Arg Gly Val Thr Phe 
        195                 200                 205             


Leu Phe Pro Ile Gln Ala Lys Thr Phe His His Val Tyr Ser Gly Lys 
    210                 215                 220                 


Asp Leu Ile Ala Gln Ala Arg Thr Gly Thr Gly Lys Thr Phe Ser Phe 
225                 230                 235                 240 


Ala Ile Pro Leu Ile Glu Lys Leu His Gly Glu Leu Gln Asp Arg Lys 
                245                 250                 255     


Arg Gly Arg Ala Pro Gln Val Leu Val Leu Ala Pro Thr Arg Glu Leu 
            260                 265                 270         


Ala Asn Gln Val Ser Lys Asp Phe Ser Asp Ile Thr Lys Lys Leu Ser 
        275                 280                 285             


Val Ala Cys Phe Tyr Gly Gly Thr Pro Tyr Gly Gly Gln Phe Glu Arg 
    290                 295                 300                 


Met Arg Asn Gly Ile Asp Ile Leu Val Gly Thr Pro Gly Arg Ile Lys 
305                 310                 315                 320 


Asp His Ile Gln Asn Gly Lys Leu Asp Leu Thr Lys Leu Lys His Val 
                325                 330                 335     


Val Leu Asp Glu Val Asp Gln Met Leu Asp Met Gly Phe Ala Asp Gln 
            340                 345                 350         


Val Glu Glu Ile Leu Ser Val Ala Tyr Lys Lys Asp Ser Glu Asp Asn 
        355                 360                 365             


Pro Gln Thr Leu Leu Phe Ser Ala Thr Cys Pro His Trp Val Phe Asn 
    370                 375                 380                 


Val Ala Lys Lys Tyr Met Lys Ser Thr Tyr Glu Gln Val Asp Leu Ile 
385                 390                 395                 400 


Gly Lys Lys Thr Gln Lys Thr Ala Ile Thr Val Glu His Leu Ala Ile 
                405                 410                 415     


Lys Cys His Trp Thr Gln Arg Ala Ala Val Ile Gly Asp Val Ile Arg 
            420                 425                 430         


Val Tyr Ser Gly His Gln Gly Arg Thr Ile Ile Phe Cys Glu Thr Lys 
        435                 440                 445             


Lys Glu Ala Gln Glu Leu Ser Gln Asn Ser Ala Ile Lys Gln Asp Ala 
    450                 455                 460                 


Gln Ser Leu His Gly Asp Ile Pro Gln Lys Gln Arg Glu Ile Thr Leu 
465                 470                 475                 480 


Lys Gly Phe Arg Asn Gly Ser Phe Gly Val Leu Val Ala Thr Asn Val 
                485                 490                 495     


Ala Ala Arg Gly Leu Asp Ile Pro Glu Val Asp Leu Val Ile Gln Ser 
            500                 505                 510         


Ser Pro Pro Lys Asp Val Glu Ser Tyr Ile His Arg Ser Gly Arg Thr 
        515                 520                 525             


Gly Arg Ala Gly Arg Thr Gly Val Cys Ile Cys Phe Tyr Gln His Lys 
    530                 535                 540                 


Glu Glu Tyr Gln Leu Val Gln Val Glu Gln Lys Ala Gly Ile Lys Phe 
545                 550                 555                 560 


Lys Arg Ile Gly Val Pro Ser Ala Thr Glu Ile Ile Lys Ala Ser Ser 
                565                 570                 575     


Lys Asp Ala Ile Arg Leu Leu Asp Ser Val Pro Pro Thr Ala Ile Ser 
            580                 585                 590         


His Phe Lys Gln Ser Ala Glu Lys Leu Ile Glu Glu Lys Gly Ala Val 
        595                 600                 605             


Glu Ala Leu Ala Ala Ala Leu Ala His Ile Ser Gly Ala Thr Ser Val 
    610                 615                 620                 


Asp Gln Arg Ser Leu Ile Asn Ser Asn Val Gly Phe Val Thr Met Ile 
625                 630                 635                 640 


Leu Gln Cys Ser Ile Glu Met Pro Asn Ile Ser Tyr Ala Trp Lys Glu 
                645                 650                 655     


Leu Lys Glu Gln Leu Gly Glu Glu Ile Asp Ser Lys Val Lys Gly Met 
            660                 665                 670         


Val Phe Leu Lys Gly Lys Leu Gly Val Cys Phe Asp Val Pro Thr Ala 
        675                 680                 685             


Ser Val Thr Glu Ile Gln Glu Lys Trp His Asp Ser Arg Arg Trp Gln 
    690                 695                 700                 


Leu Ser Val Ala Thr Glu Gln Pro Glu Leu Glu Gly Pro Arg Glu Gly 
705                 710                 715                 720 


Tyr Gly Gly Phe Arg Gly Gln Arg Glu Gly Ser Arg Gly Phe Arg Gly 
                725                 730                 735     


Gln Arg Asp Gly Asn Arg Arg Phe Arg Gly Gln Arg Glu Gly Ser Arg 
            740                 745                 750         


Gly Pro Arg Gly Gln Arg Ser Gly Gly Gly Asn Lys Ser Asn Arg Ser 
        755                 760                 765             


Gln Asn Lys Gly Gln Lys Arg Ser Phe Ser Lys Ala Phe Gly Gln 
    770                 775                 780             


<210>  2961
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX25__Homo_sapiens__NP_037396

<400>  2961

Met Ala Ser Leu Leu Trp Gly Gly Asp Ala Gly Ala Ala Glu Ser Glu 
1               5                   10                  15      


Arg Leu Asn Ser His Phe Ser Asn Leu Ser Gln Pro Arg Lys Asn Leu 
            20                  25                  30          


Trp Gly Ile Lys Ser Thr Ala Val Arg Asn Ile Asp Gly Ser Ile Asn 
        35                  40                  45              


Asn Ile Asn Glu Asp Asp Glu Glu Asp Val Val Asp Leu Ala Ala Asn 
    50                  55                  60                  


Ser Leu Leu Asn Lys Leu Ile His Gln Ser Leu Val Glu Ser Ser His 
65                  70                  75                  80  


Arg Val Glu Val Leu Gln Lys Asp Pro Ser Ser Pro Leu Tyr Ser Val 
                85                  90                  95      


Lys Thr Phe Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile 
            100                 105                 110         


Tyr Ala Met Gly Phe Asn Arg Pro Ser Lys Ile Gln Glu Met Ala Leu 
        115                 120                 125             


Pro Met Met Leu Ala His Pro Pro Gln Asn Leu Ile Ala Gln Ser Gln 
    130                 135                 140                 


Ser Gly Thr Gly Lys Thr Ala Ala Phe Val Leu Ala Met Leu Ser Arg 
145                 150                 155                 160 


Val Asn Ala Leu Glu Leu Phe Pro Gln Cys Leu Cys Leu Ala Pro Thr 
                165                 170                 175     


Tyr Glu Leu Ala Leu Gln Thr Gly Arg Val Val Glu Gln Met Gly Lys 
            180                 185                 190         


Phe Cys Val Asp Val Gln Val Met Tyr Ala Ile Arg Gly Asn Arg Ile 
        195                 200                 205             


Pro Arg Gly Thr Asp Ile Thr Lys Gln Ile Ile Ile Gly Thr Pro Gly 
    210                 215                 220                 


Thr Val Leu Asp Trp Cys Phe Lys Leu Lys Leu Ile Asp Leu Thr Lys 
225                 230                 235                 240 


Ile Arg Val Phe Val Leu Asp Glu Ala Asp Val Met Ile Asp Thr Gln 
                245                 250                 255     


Gly Phe Ser Asp His Ser Ile Arg Ile Gln Arg Ala Leu Pro Ser Glu 
            260                 265                 270         


Cys Gln Met Leu Leu Phe Ser Ala Thr Phe Glu Asp Ser Val Trp His 
        275                 280                 285             


Phe Ala Glu Arg Ile Ile Pro Asp Pro Asn Val Ile Lys Leu Arg Lys 
    290                 295                 300                 


Glu Glu Leu Thr Leu Asn Asn Ile Arg Gln Tyr Tyr Val Leu Cys Glu 
305                 310                 315                 320 


His Arg Lys Asp Lys Tyr Gln Ala Leu Cys Asn Ile Tyr Gly Ser Ile 
                325                 330                 335     


Thr Ile Gly Gln Ala Ile Ile Phe Cys Gln Thr Arg Arg Asn Ala Lys 
            340                 345                 350         


Trp Leu Thr Val Glu Met Ile Gln Asp Gly His Gln Val Ser Leu Leu 
        355                 360                 365             


Ser Gly Glu Leu Thr Val Glu Gln Arg Ala Ser Ile Ile Gln Arg Phe 
    370                 375                 380                 


Arg Asp Gly Lys Glu Lys Val Leu Ile Thr Thr Asn Val Cys Ala Arg 
385                 390                 395                 400 


Gly Ile Asp Val Lys Gln Val Thr Ile Val Val Asn Phe Asp Leu Pro 
                405                 410                 415     


Val Lys Gln Gly Glu Glu Pro Asp Tyr Glu Thr Tyr Leu His Arg Ile 
            420                 425                 430         


Gly Arg Thr Gly Arg Phe Gly Lys Lys Gly Leu Ala Phe Asn Met Ile 
        435                 440                 445             


Glu Val Asp Glu Leu Pro Ser Leu Met Lys Ile Gln Asp His Phe Asn 
    450                 455                 460                 


Ser Ser Ile Lys Gln Leu Asn Ala Glu Asp Met Asp Glu Ile Glu Lys 
465                 470                 475                 480 


Ile Asp Tyr 
            


<210>  2962
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX27__Homo_sapiens__NP_060365

<400>  2962

Met Val Leu Ala Gln Arg Arg Arg Gly Gly Cys Glu Lys Leu Arg Ala 
1               5                   10                  15      


Gly Pro Gln Ala Val Leu Ala Ser Gly Ser Gly Phe Cys Asp Asn Met 
            20                  25                  30          


Leu Ala Asp Leu Gly Leu Ile Gly Thr Ile Gly Glu Asp Asp Glu Val 
        35                  40                  45              


Pro Val Glu Pro Glu Ser Asp Ser Gly Asp Glu Glu Glu Glu Gly Pro 
    50                  55                  60                  


Ile Val Leu Gly Arg Arg Gln Lys Ala Leu Gly Lys Asn Arg Ser Ala 
65                  70                  75                  80  


Asp Phe Asn Pro Asp Phe Val Phe Thr Glu Lys Glu Gly Thr Tyr Asp 
                85                  90                  95      


Gly Ser Trp Ala Leu Ala Asp Val Met Ser Gln Leu Lys Lys Lys Arg 
            100                 105                 110         


Ala Ala Thr Thr Leu Asp Glu Lys Ile Glu Lys Val Arg Lys Lys Arg 
        115                 120                 125             


Lys Thr Glu Asp Lys Glu Ala Lys Ser Gly Lys Leu Glu Lys Glu Lys 
    130                 135                 140                 


Glu Ala Lys Glu Gly Ser Glu Pro Lys Glu Gln Glu Asp Leu Gln Glu 
145                 150                 155                 160 


Asn Asp Glu Glu Gly Ser Glu Asp Glu Ala Ser Glu Thr Asp Tyr Ser 
                165                 170                 175     


Ser Ala Asp Glu Asn Ile Leu Thr Lys Ala Asp Thr Leu Lys Val Lys 
            180                 185                 190         


Asp Arg Lys Lys Lys Lys Lys Lys Gly Gln Glu Ala Gly Gly Phe Phe 
        195                 200                 205             


Glu Asp Ala Ser Gln Tyr Asp Glu Asn Leu Ser Phe Gln Asp Met Asn 
    210                 215                 220                 


Leu Ser Arg Pro Leu Leu Lys Ala Ile Thr Ala Met Gly Phe Lys Gln 
225                 230                 235                 240 


Pro Thr Pro Ile Gln Lys Ala Cys Ile Pro Val Gly Leu Leu Gly Lys 
                245                 250                 255     


Asp Ile Cys Ala Cys Ala Ala Thr Gly Thr Gly Lys Thr Ala Ala Phe 
            260                 265                 270         


Ala Leu Pro Val Leu Glu Arg Leu Ile Tyr Lys Pro Arg Gln Ala Pro 
        275                 280                 285             


Val Thr Arg Val Leu Val Leu Val Pro Thr Arg Glu Leu Gly Ile Gln 
    290                 295                 300                 


Val His Ser Val Thr Arg Gln Leu Ala Gln Phe Cys Asn Ile Thr Thr 
305                 310                 315                 320 


Cys Leu Ala Val Gly Gly Leu Asp Val Lys Ser Gln Glu Ala Ala Leu 
                325                 330                 335     


Arg Ala Ala Pro Asp Ile Leu Ile Ala Thr Pro Gly Arg Leu Ile Asp 
            340                 345                 350         


His Leu His Asn Cys Pro Ser Phe His Leu Ser Ser Ile Glu Val Leu 
        355                 360                 365             


Ile Leu Asp Glu Ala Asp Arg Met Leu Asp Glu Tyr Phe Glu Glu Gln 
    370                 375                 380                 


Met Lys Glu Ile Ile Arg Met Cys Ser His His Arg Gln Thr Met Leu 
385                 390                 395                 400 


Phe Ser Ala Thr Met Thr Asp Glu Val Lys Asp Leu Ala Ser Val Ser 
                405                 410                 415     


Leu Lys Asn Pro Val Arg Ile Phe Val Asn Ser Asn Thr Asp Val Ala 
            420                 425                 430         


Pro Phe Leu Arg Gln Glu Phe Ile Arg Ile Arg Pro Asn Arg Glu Gly 
        435                 440                 445             


Asp Arg Glu Ala Ile Val Ala Ala Leu Leu Thr Arg Thr Phe Thr Asp 
    450                 455                 460                 


His Val Met Leu Phe Thr Gln Thr Lys Lys Gln Ala His Arg Met His 
465                 470                 475                 480 


Ile Leu Leu Gly Leu Met Gly Leu Gln Val Gly Glu Leu His Gly Asn 
                485                 490                 495     


Leu Ser Gln Thr Gln Arg Leu Glu Ala Leu Arg Arg Phe Lys Asp Glu 
            500                 505                 510         


Gln Ile Asp Ile Leu Val Ala Thr Asp Val Ala Ala Arg Gly Leu Asp 
        515                 520                 525             


Ile Glu Gly Val Lys Thr Val Ile Asn Phe Thr Met Pro Asn Thr Ile 
    530                 535                 540                 


Lys His Tyr Val His Arg Val Gly Arg Thr Ala Arg Ala Gly Arg Ala 
545                 550                 555                 560 


Gly Arg Ser Val Ser Leu Val Gly Glu Asp Glu Arg Lys Met Leu Lys 
                565                 570                 575     


Glu Ile Val Lys Ala Ala Lys Ala Pro Val Lys Ala Arg Ile Leu Pro 
            580                 585                 590         


Gln Asp Val Ile Leu Lys Phe Arg Asp Lys Ile Glu Lys Met Glu Lys 
        595                 600                 605             


Asp Val Tyr Ala Val Leu Gln Leu Glu Ala Glu Glu Lys Glu Met Gln 
    610                 615                 620                 


Gln Ser Glu Ala Gln Ile Asn Thr Ala Lys Arg Leu Leu Glu Lys Gly 
625                 630                 635                 640 


Lys Glu Ala Val Val Gln Glu Pro Glu Arg Ser Trp Phe Gln Thr Lys 
                645                 650                 655     


Glu Glu Arg Lys Lys Glu Lys Ile Ala Lys Ala Leu Gln Glu Phe Asp 
            660                 665                 670         


Leu Ala Leu Arg Gly Lys Lys Lys Arg Lys Lys Phe Met Lys Asp Ala 
        675                 680                 685             


Lys Lys Lys Gly Glu Met Thr Ala Glu Glu Arg Ser Gln Phe Glu Ile 
    690                 695                 700                 


Leu Lys Ala Gln Met Phe Ala Glu Arg Leu Ala Lys Arg Asn Arg Arg 
705                 710                 715                 720 


Ala Lys Arg Ala Arg Ala Met Pro Glu Glu Glu Pro Val Arg Gly Pro 
                725                 730                 735     


Ala Lys Lys Gln Lys Gln Gly Lys Lys Ser Val Phe Asp Glu Glu Leu 
            740                 745                 750         


Thr Asn Thr Ser Lys Lys Ala Leu Lys Gln Tyr Arg Ala Gly Pro Ser 
        755                 760                 765             


Phe Glu Glu Arg Lys Gln Leu Gly Leu Pro His Gln Arg Arg Gly Gly 
    770                 775                 780                 


Asn Phe Lys Ser Lys Ser Arg Tyr Lys Arg Arg Lys 
785                 790                 795     


<210>  2963
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX28__Homo_sapiens__NP_060850

<400>  2963

Met Ala Leu Thr Arg Pro Val Arg Leu Phe Ser Leu Val Thr Arg Leu 
1               5                   10                  15      


Leu Leu Ala Pro Arg Arg Gly Leu Thr Val Arg Ser Pro Asp Glu Pro 
            20                  25                  30          


Leu Pro Val Val Arg Ile Pro Val Ala Leu Gln Arg Gln Leu Glu Gln 
        35                  40                  45              


Arg Gln Ser Arg Arg Arg Asn Leu Pro Arg Pro Val Leu Val Arg Pro 
    50                  55                  60                  


Gly Pro Leu Leu Val Ser Ala Arg Arg Pro Glu Leu Asn Gln Pro Ala 
65                  70                  75                  80  


Arg Leu Thr Leu Gly Arg Trp Glu Arg Ala Pro Leu Ala Ser Gln Gly 
                85                  90                  95      


Trp Lys Ser Arg Arg Ala Arg Arg Asp His Phe Ser Ile Glu Arg Ala 
            100                 105                 110         


Gln Gln Glu Ala Pro Ala Val Arg Lys Leu Ser Ser Lys Gly Ser Phe 
        115                 120                 125             


Ala Asp Leu Gly Leu Glu Pro Arg Val Leu His Ala Leu Gln Glu Ala 
    130                 135                 140                 


Ala Pro Glu Val Val Gln Pro Thr Thr Val Gln Ser Ser Thr Ile Pro 
145                 150                 155                 160 


Ser Leu Leu Arg Gly Arg His Val Val Cys Ala Ala Glu Thr Gly Ser 
                165                 170                 175     


Gly Lys Thr Leu Ser Tyr Leu Leu Pro Leu Leu Gln Arg Leu Leu Gly 
            180                 185                 190         


Gln Pro Ser Leu Asp Ser Leu Pro Ile Pro Ala Pro Arg Gly Leu Val 
        195                 200                 205             


Leu Val Pro Ser Arg Glu Leu Ala Gln Gln Val Arg Ala Val Ala Gln 
    210                 215                 220                 


Pro Leu Gly Arg Ser Leu Gly Leu Leu Val Arg Asp Leu Glu Gly Gly 
225                 230                 235                 240 


His Gly Met Arg Arg Ile Arg Leu Gln Leu Ser Arg Gln Pro Ser Ala 
                245                 250                 255     


Asp Val Leu Val Ala Thr Pro Gly Ala Leu Trp Lys Ala Leu Lys Ser 
            260                 265                 270         


Arg Leu Ile Ser Leu Glu Gln Leu Ser Phe Leu Val Leu Asp Glu Ala 
        275                 280                 285             


Asp Thr Leu Leu Asp Glu Ser Phe Leu Glu Leu Val Asp Tyr Ile Leu 
    290                 295                 300                 


Glu Lys Ser His Ile Ala Glu Gly Pro Ala Asp Leu Glu Asp Pro Phe 
305                 310                 315                 320 


Asn Pro Lys Ala Gln Leu Val Leu Val Gly Ala Thr Phe Pro Glu Gly 
                325                 330                 335     


Val Gly Gln Leu Leu Asn Lys Val Ala Ser Pro Asp Ala Val Thr Thr 
            340                 345                 350         


Ile Thr Ser Ser Lys Leu His Cys Ile Met Pro His Val Lys Gln Thr 
        355                 360                 365             


Phe Leu Arg Leu Lys Gly Ala Asp Lys Val Ala Glu Leu Val His Ile 
    370                 375                 380                 


Leu Lys His Arg Asp Arg Ala Glu Arg Thr Gly Pro Ser Gly Thr Val 
385                 390                 395                 400 


Leu Val Phe Cys Asn Ser Ser Ser Thr Val Asn Trp Leu Gly Tyr Ile 
                405                 410                 415     


Leu Asp Asp His Lys Ile Gln His Leu Arg Leu Gln Gly Gln Met Pro 
            420                 425                 430         


Ala Leu Met Arg Val Gly Ile Phe Gln Ser Phe Gln Lys Ser Ser Arg 
        435                 440                 445             


Asp Ile Leu Leu Cys Thr Asp Ile Ala Ser Arg Gly Leu Asp Ser Thr 
    450                 455                 460                 


Gly Val Glu Leu Val Val Asn Tyr Asp Phe Pro Pro Thr Leu Gln Asp 
465                 470                 475                 480 


Tyr Ile His Arg Ala Gly Arg Val Gly Arg Val Gly Ser Glu Val Pro 
                485                 490                 495     


Gly Thr Val Ile Ser Phe Val Thr His Pro Trp Asp Val Ser Leu Val 
            500                 505                 510         


Gln Lys Ile Glu Leu Ala Ala Arg Arg Arg Arg Ser Leu Pro Gly Leu 
        515                 520                 525             


Ala Ser Ser Val Lys Glu Pro Leu Pro Gln Ala Thr 
    530                 535                 540 


<210>  2964
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX31__Homo_sapiens__NP_073616

<400>  2964

Met Ala Pro Asp Leu Ala Ser Gln Arg His Ser Glu Ser Phe Pro Ser 
1               5                   10                  15      


Val Asn Ser Arg Pro Asn Val Ile Leu Pro Gly Arg Glu Gly Arg Arg 
            20                  25                  30          


Glu Gly Leu Pro Pro Gly Gly Gly Thr Arg Gly Ser Leu Val Pro Thr 
        35                  40                  45              


Arg Pro Val Pro Pro Ser Pro Ala Pro Leu Gly Thr Ser Pro Tyr Ser 
    50                  55                  60                  


Trp Ser Arg Ser Gly Pro Gly Arg Gly Gly Gly Ala Gly Ser Ser Arg 
65                  70                  75                  80  


Val Pro Arg Gly Val Pro Gly Pro Ala Val Cys Ala Pro Gly Ser Leu 
                85                  90                  95      


Leu His His Ala Ser Pro Thr Gln Thr Met Ala Ala Ala Asp Gly Ser 
            100                 105                 110         


Leu Phe Asp Asn Pro Arg Thr Phe Ser Arg Arg Pro Pro Ala Gln Ala 
        115                 120                 125             


Ser Arg Gln Ala Lys Ala Thr Lys Arg Lys Tyr Gln Ala Ser Ser Glu 
    130                 135                 140                 


Ala Pro Pro Ala Lys Arg Arg Asn Glu Thr Ser Phe Leu Pro Ala Lys 
145                 150                 155                 160 


Lys Thr Ser Val Lys Glu Thr Gln Arg Thr Phe Lys Gly Asn Ala Gln 
                165                 170                 175     


Lys Met Phe Ser Pro Lys Lys His Ser Val Ser Thr Ser Asp Arg Asn 
            180                 185                 190         


Gln Glu Glu Arg Gln Cys Ile Lys Thr Ser Ser Leu Phe Lys Asn Asn 
        195                 200                 205             


Pro Asp Ile Pro Glu Leu His Arg Pro Val Val Lys Gln Val Gln Glu 
    210                 215                 220                 


Lys Val Phe Thr Ser Ala Ala Phe His Glu Leu Gly Leu His Pro His 
225                 230                 235                 240 


Leu Ile Ser Thr Ile Asn Thr Val Leu Lys Met Ser Ser Met Thr Ser 
                245                 250                 255     


Val Gln Lys Gln Ser Ile Pro Val Leu Leu Glu Gly Arg Asp Ala Leu 
            260                 265                 270         


Val Arg Ser Gln Thr Gly Ser Gly Lys Thr Leu Ala Tyr Cys Ile Pro 
        275                 280                 285             


Val Val Gln Ser Leu Gln Ala Met Glu Ser Lys Ile Gln Arg Ser Asp 
    290                 295                 300                 


Gly Pro Tyr Ala Leu Val Leu Val Pro Thr Arg Glu Leu Ala Leu Gln 
305                 310                 315                 320 


Ser Phe Asp Thr Val Gln Lys Leu Leu Lys Pro Phe Thr Trp Ile Val 
                325                 330                 335     


Pro Gly Val Leu Met Gly Gly Glu Lys Arg Lys Ser Glu Lys Ala Arg 
            340                 345                 350         


Leu Arg Lys Gly Ile Asn Ile Leu Ile Ser Thr Pro Gly Arg Leu Val 
        355                 360                 365             


Asp His Ile Lys Ser Thr Lys Asn Ile His Phe Ser Arg Leu Arg Trp 
    370                 375                 380                 


Leu Val Phe Asp Glu Ala Asp Arg Ile Leu Asp Leu Gly Phe Glu Lys 
385                 390                 395                 400 


Asp Ile Thr Val Ile Leu Asn Ala Val Asn Ala Glu Cys Gln Lys Arg 
                405                 410                 415     


Gln Asn Val Leu Leu Ser Ala Thr Leu Thr Glu Gly Val Thr Arg Leu 
            420                 425                 430         


Ala Asp Ile Ser Leu His Asp Pro Val Ser Ile Ser Val Leu Asp Lys 
        435                 440                 445             


Ser His Asp Gln Leu Asn Pro Lys Asp Lys Ala Val Gln Glu Val Cys 
    450                 455                 460                 


Pro Pro Pro Ala Gly Asp Lys Leu Asp Ser Phe Ala Ile Pro Glu Ser 
465                 470                 475                 480 


Leu Lys Gln His Val Thr Val Val Pro Ser Lys Leu Arg Leu Val Cys 
                485                 490                 495     


Leu Ala Ala Phe Ile Leu Gln Lys Cys Lys Phe Glu Glu Asp Gln Lys 
            500                 505                 510         


Met Val Val Phe Phe Ser Ser Cys Glu Leu Val Glu Phe His Tyr Ser 
        515                 520                 525             


Leu Phe Leu Gln Thr Leu Leu Ser Ser Ser Gly Ala Pro Ala Ser Gly 
    530                 535                 540                 


Gln Leu Pro Ser Ala Ser Met Arg Leu Lys Phe Leu Arg Leu His Gly 
545                 550                 555                 560 


Gly Met Glu Gln Glu Glu Arg Thr Ala Val Phe Gln Glu Phe Ser His 
                565                 570                 575     


Ser Arg Arg Gly Val Leu Leu Cys Thr Asp Val Ala Ala Arg Gly Leu 
            580                 585                 590         


Asp Leu Pro Gln Val Thr Trp Ile Val Gln Tyr Asn Ala Pro Ser Ser 
        595                 600                 605             


Pro Ala Glu Tyr Ile His Arg Ile Gly Arg Thr Ala Arg Ile Gly Cys 
    610                 615                 620                 


His Gly Ser Ser Leu Leu Ile Leu Ala Pro Ser Glu Ala Glu Tyr Val 
625                 630                 635                 640 


Asn Ser Leu Ala Ser His Lys Ile Asn Val Ser Glu Ile Lys Met Glu 
                645                 650                 655     


Asp Ile Leu Cys Val Leu Thr Arg Asp Asp Cys Phe Lys Gly Lys Arg 
            660                 665                 670         


Trp Gly Ala Gln Lys Ser His Ala Val Gly Pro Gln Glu Ile Arg Glu 
        675                 680                 685             


Arg Ala Thr Val Leu Gln Thr Val Phe Glu Asp Tyr Val His Ser Ser 
    690                 695                 700                 


Glu Arg Arg Val Ser Trp Ala Lys Lys Ala Leu Gln Ser Phe Ile Gln 
705                 710                 715                 720 


Ala Tyr Ala Thr Tyr Pro Arg Glu Leu Lys His Ile Phe His Val Arg 
                725                 730                 735     


Ser Leu His Leu Gly His Val Ala Lys Ser Phe Gly Leu Arg Asp Ala 
            740                 745                 750         


Pro Arg Asn Leu Ser Ala Leu Thr Arg Lys Lys Arg Lys Ala His Val 
        755                 760                 765             


Lys Arg Pro Asp Leu His Lys Lys Thr Gln Ser Lys His Ser Leu Ala 
    770                 775                 780                 


Glu Ile Leu Arg Ser Glu Tyr Ser Ser Gly Met Glu Ala Asp Ile Ala 
785                 790                 795                 800 


Lys Val Lys Lys Gln Asn Ala Pro Gly Glu Pro Gly Gly Arg Pro Leu 
                805                 810                 815     


Gln His Ser Leu Gln Pro Thr Pro Cys Phe Gly Arg Gly Lys Thr Leu 
            820                 825                 830         


Lys Trp Arg Lys Thr Gln Lys Gly Val Gln Arg Asp Ser Lys Thr Ser 
        835                 840                 845             


Gln Lys Val 
    850     


<210>  2965
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX39A__Homo_sapiens__NP_005795

<400>  2965

Met Ala Glu Gln Asp Val Glu Asn Asp Leu Leu Asp Tyr Asp Glu Glu 
1               5                   10                  15      


Glu Glu Pro Gln Ala Pro Gln Glu Ser Thr Pro Ala Pro Pro Lys Lys 
            20                  25                  30          


Asp Ile Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg Asp 
        35                  40                  45              


Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly Phe 
    50                  55                  60                  


Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile Leu 
65                  70                  75                  80  


Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr Ala 
                85                  90                  95      


Val Phe Val Leu Ala Thr Leu Gln Gln Ile Glu Pro Val Asn Gly Gln 
            100                 105                 110         


Val Thr Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln Ile 
        115                 120                 125             


Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Ser Val Lys Val 
    130                 135                 140                 


Ser Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val Leu 
145                 150                 155                 160 


Lys Lys Asn Cys Pro His Val Val Val Gly Thr Pro Gly Arg Ile Leu 
                165                 170                 175     


Ala Leu Val Arg Asn Arg Ser Phe Ser Leu Lys Asn Val Lys His Phe 
            180                 185                 190         


Val Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg Arg 
        195                 200                 205             


Asp Val Gln Glu Ile Phe Arg Leu Thr Pro His Glu Lys Gln Cys Met 
    210                 215                 220                 


Met Phe Ser Ala Thr Leu Ser Lys Asp Ile Arg Pro Val Cys Arg Lys 
225                 230                 235                 240 


Phe Met Gln Asp Pro Met Glu Val Phe Val Asp Asp Glu Thr Lys Leu 
                245                 250                 255     


Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Ser Glu 
            260                 265                 270         


Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn Gln 
        275                 280                 285             


Val Ile Ile Phe Val Lys Ser Val Gln Arg Cys Met Ala Leu Ala Gln 
    290                 295                 300                 


Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly Met 
305                 310                 315                 320 


Ala Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe Gln 
                325                 330                 335     


Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp Ile 
            340                 345                 350         


Glu Arg Val Asn Ile Val Phe Asn Tyr Asp Met Pro Glu Asp Ser Asp 
        355                 360                 365             


Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys Gly 
    370                 375                 380                 


Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu Asn 
385                 390                 395                 400 


Asp Val Gln Asp Arg Phe Glu Val Asn Val Ala Glu Leu Pro Glu Glu 
                405                 410                 415     


Ile Asp Ile Ser Thr Tyr Ile Glu Gln Ser Arg 
            420                 425         


<210>  2966
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX39B__Homo_sapiens__NP_542165

<400>  2966

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
1               5                   10                  15      


Glu Val Glu Thr Ala Ala Gly Gly Asp Gly Ala Glu Ala Pro Ala Lys 
            20                  25                  30          


Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
        35                  40                  45              


Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
    50                  55                  60                  


Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
65                  70                  75                  80  


Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                85                  90                  95      


Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
            100                 105                 110         


Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
        115                 120                 125             


Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
    130                 135                 140                 


Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
145                 150                 155                 160 


Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                165                 170                 175     


Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
            180                 185                 190         


Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
        195                 200                 205             


Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
    210                 215                 220                 


Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
225                 230                 235                 240 


Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                245                 250                 255     


Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
            260                 265                 270         


Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
        275                 280                 285             


Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
    290                 295                 300                 


Gln Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly 
305                 310                 315                 320 


Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                325                 330                 335     


Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
            340                 345                 350         


Ile Glu Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
        355                 360                 365             


Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
    370                 375                 380                 


Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
385                 390                 395                 400 


Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                405                 410                 415     


Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
            420                 425             


<210>  2967
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX3X__Homo_sapiens__NP_001180345

<400>  2967

Met Ser His Val Ala Val Glu Asn Ala Leu Gly Leu Asp Gln Gln Phe 
1               5                   10                  15      


Ala Gly Leu Asp Leu Asn Ser Ser Asp Asn Gln Ser Gly Gly Ser Thr 
            20                  25                  30          


Ala Ser Lys Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala 
        35                  40                  45              


Thr Lys Gly Phe Tyr Asp Lys Asp Ser Ser Gly Trp Ser Ser Ser Lys 
    50                  55                  60                  


Asp Lys Asp Ala Tyr Ser Ser Phe Gly Ser Arg Ser Asp Ser Arg Gly 
65                  70                  75                  80  


Lys Ser Ser Phe Phe Ser Asp Arg Gly Ser Gly Ser Arg Gly Arg Phe 
                85                  90                  95      


Asp Asp Arg Gly Arg Ser Asp Tyr Asp Gly Ile Gly Ser Arg Gly Asp 
            100                 105                 110         


Arg Ser Gly Phe Gly Lys Phe Glu Arg Gly Gly Asn Ser Arg Trp Cys 
        115                 120                 125             


Asp Lys Ser Asp Glu Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu 
    130                 135                 140                 


Arg Leu Glu Gln Glu Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe 
145                 150                 155                 160 


Glu Lys Tyr Asp Asp Ile Pro Val Glu Ala Thr Gly Asn Asn Cys Pro 
                165                 170                 175     


Pro His Ile Glu Ser Phe Ser Asp Val Glu Met Gly Glu Ile Ile Met 
            180                 185                 190         


Gly Asn Ile Glu Leu Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys 
        195                 200                 205             


His Ala Ile Pro Ile Ile Lys Glu Lys Arg Asp Leu Met Ala Cys Ala 
    210                 215                 220                 


Gln Thr Gly Ser Gly Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser 
225                 230                 235                 240 


Gln Ile Tyr Ser Asp Gly Pro Gly Glu Ala Leu Arg Ala Met Lys Glu 
                245                 250                 255     


Asn Gly Arg Tyr Gly Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu 
            260                 265                 270         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys 
        275                 280                 285             


Phe Ser Tyr Arg Ser Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala 
    290                 295                 300                 


Asp Ile Gly Gln Gln Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu 
305                 310                 315                 320 


Val Ala Thr Pro Gly Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile 
                325                 330                 335     


Gly Leu Asp Phe Cys Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met 
            340                 345                 350         


Leu Asp Met Gly Phe Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp 
        355                 360                 365             


Thr Met Pro Pro Lys Gly Val Arg His Thr Met Met Phe Ser Ala Thr 
    370                 375                 380                 


Phe Pro Lys Glu Ile Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr 
385                 390                 395                 400 


Ile Phe Leu Ala Val Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr 
                405                 410                 415     


Gln Lys Val Val Trp Val Glu Glu Ser Asp Lys Arg Ser Phe Leu Leu 
            420                 425                 430         


Asp Leu Leu Asn Ala Thr Gly Lys Asp Ser Leu Thr Leu Val Phe Val 
        435                 440                 445             


Glu Thr Lys Lys Gly Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu 
    450                 455                 460                 


Gly Tyr Ala Cys Thr Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg 
465                 470                 475                 480 


Glu Glu Ala Leu His Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val 
                485                 490                 495     


Ala Thr Ala Val Ala Ala Arg Gly Leu Asp Ile Ser Asn Val Lys His 
            500                 505                 510         


Val Ile Asn Phe Asp Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg 
        515                 520                 525             


Ile Gly Arg Thr Gly Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe 
    530                 535                 540                 


Phe Asn Glu Arg Asn Ile Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu 
545                 550                 555                 560 


Val Glu Ala Lys Gln Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr 
                565                 570                 575     


Glu His His Tyr Lys Gly Ser Ser Arg Gly Arg Ser Lys Ser Arg Phe 
            580                 585                 590         


Ser Gly Gly Phe Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ala Ser 
        595                 600                 605             


Ser Ser Ser Phe Ser Ser Ser Arg Ala Ser Ser Ser Arg Ser Gly Gly 
    610                 615                 620                 


Gly Gly His Gly Ser Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly 
625                 630                 635                 640 


Phe Tyr Asn Ser Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val 
                645                 650                 655     


Asp Trp Trp Gly Asn 
            660     


<210>  2968
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX3Y__Homo_sapiens__NP_001289481

<400>  2968

Met Glu Ile Gly Arg Pro Arg Lys Asp Thr Trp Lys Leu Ala Asn Leu 
1               5                   10                  15      


Asp Leu Asn Ser Glu Lys Gln Ser Gly Gly Ala Ser Thr Ala Ser Lys 
            20                  25                  30          


Gly Arg Tyr Ile Pro Pro His Leu Arg Asn Arg Glu Ala Ser Lys Gly 
        35                  40                  45              


Phe His Asp Lys Asp Ser Ser Gly Trp Ser Cys Ser Lys Asp Lys Asp 
    50                  55                  60                  


Ala Tyr Ser Ser Phe Gly Ser Arg Asp Ser Arg Gly Lys Pro Gly Tyr 
65                  70                  75                  80  


Phe Ser Glu Arg Gly Ser Gly Ser Arg Gly Arg Phe Asp Asp Arg Gly 
                85                  90                  95      


Arg Ser Asp Tyr Asp Gly Ile Gly Asn Arg Glu Arg Pro Gly Phe Gly 
            100                 105                 110         


Arg Phe Glu Arg Ser Gly His Ser Arg Trp Cys Asp Lys Ser Val Glu 
        115                 120                 125             


Asp Asp Trp Ser Lys Pro Leu Pro Pro Ser Glu Arg Leu Glu Gln Glu 
    130                 135                 140                 


Leu Phe Ser Gly Gly Asn Thr Gly Ile Asn Phe Glu Lys Tyr Asp Asp 
145                 150                 155                 160 


Ile Pro Val Glu Ala Thr Gly Ser Asn Cys Pro Pro His Ile Glu Asn 
                165                 170                 175     


Phe Ser Asp Ile Asp Met Gly Glu Ile Ile Met Gly Asn Ile Glu Leu 
            180                 185                 190         


Thr Arg Tyr Thr Arg Pro Thr Pro Val Gln Lys His Ala Ile Pro Ile 
        195                 200                 205             


Ile Lys Gly Lys Arg Asp Leu Met Ala Cys Ala Gln Thr Gly Ser Gly 
    210                 215                 220                 


Lys Thr Ala Ala Phe Leu Leu Pro Ile Leu Ser Gln Ile Tyr Thr Asp 
225                 230                 235                 240 


Gly Pro Gly Glu Ala Leu Lys Ala Val Lys Glu Asn Gly Arg Tyr Gly 
                245                 250                 255     


Arg Arg Lys Gln Tyr Pro Ile Ser Leu Val Leu Ala Pro Thr Arg Glu 
            260                 265                 270         


Leu Ala Val Gln Ile Tyr Glu Glu Ala Arg Lys Phe Ser Tyr Arg Ser 
        275                 280                 285             


Arg Val Arg Pro Cys Val Val Tyr Gly Gly Ala Asp Ile Gly Gln Gln 
    290                 295                 300                 


Ile Arg Asp Leu Glu Arg Gly Cys His Leu Leu Val Ala Thr Pro Gly 
305                 310                 315                 320 


Arg Leu Val Asp Met Met Glu Arg Gly Lys Ile Gly Leu Asp Phe Cys 
                325                 330                 335     


Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe 
            340                 345                 350         


Glu Pro Gln Ile Arg Arg Ile Val Glu Gln Asp Thr Met Pro Pro Lys 
        355                 360                 365             


Gly Val Arg His Thr Met Met Phe Ser Ala Thr Phe Pro Lys Glu Ile 
    370                 375                 380                 


Gln Met Leu Ala Arg Asp Phe Leu Asp Glu Tyr Ile Phe Leu Ala Val 
385                 390                 395                 400 


Gly Arg Val Gly Ser Thr Ser Glu Asn Ile Thr Gln Lys Val Val Trp 
                405                 410                 415     


Val Glu Asp Leu Asp Lys Arg Ser Phe Leu Leu Asp Ile Leu Gly Ala 
            420                 425                 430         


Thr Gly Ser Asp Ser Leu Thr Leu Val Phe Val Glu Thr Lys Lys Gly 
        435                 440                 445             


Ala Asp Ser Leu Glu Asp Phe Leu Tyr His Glu Gly Tyr Ala Cys Thr 
    450                 455                 460                 


Ser Ile His Gly Asp Arg Ser Gln Arg Asp Arg Glu Glu Ala Leu His 
465                 470                 475                 480 


Gln Phe Arg Ser Gly Lys Ser Pro Ile Leu Val Ala Thr Ala Val Ala 
                485                 490                 495     


Ala Arg Gly Leu Asp Ile Ser Asn Val Arg His Val Ile Asn Phe Asp 
            500                 505                 510         


Leu Pro Ser Asp Ile Glu Glu Tyr Val His Arg Ile Gly Arg Thr Gly 
        515                 520                 525             


Arg Val Gly Asn Leu Gly Leu Ala Thr Ser Phe Phe Asn Glu Lys Asn 
    530                 535                 540                 


Met Asn Ile Thr Lys Asp Leu Leu Asp Leu Leu Val Glu Ala Lys Gln 
545                 550                 555                 560 


Glu Val Pro Ser Trp Leu Glu Asn Met Ala Tyr Glu His His Tyr Lys 
                565                 570                 575     


Gly Gly Ser Arg Gly Arg Ser Lys Ser Asn Arg Phe Ser Gly Gly Phe 
            580                 585                 590         


Gly Ala Arg Asp Tyr Arg Gln Ser Ser Gly Ser Ser Ser Ser Gly Phe 
        595                 600                 605             


Gly Ala Ser Arg Gly Ser Ser Ser Arg Ser Gly Gly Gly Gly Tyr Gly 
    610                 615                 620                 


Asn Ser Arg Gly Phe Gly Gly Gly Gly Tyr Gly Gly Phe Tyr Asn Ser 
625                 630                 635                 640 


Asp Gly Tyr Gly Gly Asn Tyr Asn Ser Gln Gly Val Asp Trp Trp Gly 
                645                 650                 655     


Asn 
    


<210>  2969
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX41__Homo_sapiens__NP_057306

<400>  2969

Met Glu Glu Ser Glu Pro Glu Arg Lys Arg Ala Arg Thr Asp Glu Val 
1               5                   10                  15      


Pro Ala Gly Gly Ser Arg Ser Glu Ala Glu Asp Glu Asp Asp Glu Asp 
            20                  25                  30          


Tyr Val Pro Tyr Val Pro Leu Arg Gln Arg Arg Gln Leu Leu Leu Gln 
        35                  40                  45              


Lys Leu Leu Gln Arg Arg Arg Lys Gly Ala Ala Glu Glu Glu Gln Gln 
    50                  55                  60                  


Asp Ser Gly Ser Glu Pro Arg Gly Asp Glu Asp Asp Ile Pro Leu Gly 
65                  70                  75                  80  


Pro Gln Ser Asn Val Ser Leu Leu Asp Gln His Gln His Leu Lys Glu 
                85                  90                  95      


Lys Ala Glu Ala Arg Lys Glu Ser Ala Lys Glu Lys Gln Leu Lys Glu 
            100                 105                 110         


Glu Glu Lys Ile Leu Glu Ser Val Ala Glu Gly Arg Ala Leu Met Ser 
        115                 120                 125             


Val Lys Glu Met Ala Lys Gly Ile Thr Tyr Asp Asp Pro Ile Lys Thr 
    130                 135                 140                 


Ser Trp Thr Pro Pro Arg Tyr Val Leu Ser Met Ser Glu Glu Arg His 
145                 150                 155                 160 


Glu Arg Val Arg Lys Lys Tyr His Ile Leu Val Glu Gly Asp Gly Ile 
                165                 170                 175     


Pro Pro Pro Ile Lys Ser Phe Lys Glu Met Lys Phe Pro Ala Ala Ile 
            180                 185                 190         


Leu Arg Gly Leu Lys Lys Lys Gly Ile His His Pro Thr Pro Ile Gln 
        195                 200                 205             


Ile Gln Gly Ile Pro Thr Ile Leu Ser Gly Arg Asp Met Ile Gly Ile 
    210                 215                 220                 


Ala Phe Thr Gly Ser Gly Lys Thr Leu Val Phe Thr Leu Pro Val Ile 
225                 230                 235                 240 


Met Phe Cys Leu Glu Gln Glu Lys Arg Leu Pro Phe Ser Lys Arg Glu 
                245                 250                 255     


Gly Pro Tyr Gly Leu Ile Ile Cys Pro Ser Arg Glu Leu Ala Arg Gln 
            260                 265                 270         


Thr His Gly Ile Leu Glu Tyr Tyr Cys Arg Leu Leu Gln Glu Asp Ser 
        275                 280                 285             


Ser Pro Leu Leu Arg Cys Ala Leu Cys Ile Gly Gly Met Ser Val Lys 
    290                 295                 300                 


Glu Gln Met Glu Thr Ile Arg His Gly Val His Met Met Val Ala Thr 
305                 310                 315                 320 


Pro Gly Arg Leu Met Asp Leu Leu Gln Lys Lys Met Val Ser Leu Asp 
                325                 330                 335     


Ile Cys Arg Tyr Leu Ala Leu Asp Glu Ala Asp Arg Met Ile Asp Met 
            340                 345                 350         


Gly Phe Glu Gly Asp Ile Arg Thr Ile Phe Ser Tyr Phe Lys Gly Gln 
        355                 360                 365             


Arg Gln Thr Leu Leu Phe Ser Ala Thr Met Pro Lys Lys Ile Gln Asn 
    370                 375                 380                 


Phe Ala Lys Ser Ala Leu Val Lys Pro Val Thr Ile Asn Val Gly Arg 
385                 390                 395                 400 


Ala Gly Ala Ala Ser Leu Asp Val Ile Gln Glu Val Glu Tyr Val Lys 
                405                 410                 415     


Glu Glu Ala Lys Met Val Tyr Leu Leu Glu Cys Leu Gln Lys Thr Pro 
            420                 425                 430         


Pro Pro Val Leu Ile Phe Ala Glu Lys Lys Ala Asp Val Asp Ala Ile 
        435                 440                 445             


His Glu Tyr Leu Leu Leu Lys Gly Val Glu Ala Val Ala Ile His Gly 
    450                 455                 460                 


Gly Lys Asp Gln Glu Glu Arg Thr Lys Ala Ile Glu Ala Phe Arg Glu 
465                 470                 475                 480 


Gly Lys Lys Asp Val Leu Val Ala Thr Asp Val Ala Ser Lys Gly Leu 
                485                 490                 495     


Asp Phe Pro Ala Ile Gln His Val Ile Asn Tyr Asp Met Pro Glu Glu 
            500                 505                 510         


Ile Glu Asn Tyr Val His Arg Ile Gly Arg Thr Gly Arg Ser Gly Asn 
        515                 520                 525             


Thr Gly Ile Ala Thr Thr Phe Ile Asn Lys Ala Cys Asp Glu Ser Val 
    530                 535                 540                 


Leu Met Asp Leu Lys Ala Leu Leu Leu Glu Ala Lys Gln Lys Val Pro 
545                 550                 555                 560 


Pro Val Leu Gln Val Leu His Cys Gly Asp Glu Ser Met Leu Asp Ile 
                565                 570                 575     


Gly Gly Glu Arg Gly Cys Ala Phe Cys Gly Gly Leu Gly His Arg Ile 
            580                 585                 590         


Thr Asp Cys Pro Lys Leu Glu Ala Met Gln Thr Lys Gln Val Ser Asn 
        595                 600                 605             


Ile Gly Arg Lys Asp Tyr Leu Ala His Ser Ser Met Asp Phe 
    610                 615                 620         


<210>  2970
<211>  938
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX42__Homo_sapiens__NP_987095

<400>  2970

Met Asn Trp Asn Lys Gly Gly Pro Gly Thr Lys Arg Gly Phe Gly Phe 
1               5                   10                  15      


Gly Gly Phe Ala Ile Ser Ala Gly Lys Lys Glu Glu Pro Lys Leu Pro 
            20                  25                  30          


Gln Gln Ser His Ser Ala Phe Gly Ala Thr Ser Ser Ser Ser Gly Phe 
        35                  40                  45              


Gly Lys Ser Ala Pro Pro Gln Leu Pro Ser Phe Tyr Lys Ile Gly Ser 
    50                  55                  60                  


Lys Arg Ala Asn Phe Asp Glu Glu Asn Ala Tyr Phe Glu Asp Glu Glu 
65                  70                  75                  80  


Glu Asp Ser Ser Asn Val Asp Leu Pro Tyr Ile Pro Ala Glu Asn Ser 
                85                  90                  95      


Pro Thr Arg Gln Gln Phe His Ser Lys Pro Val Asp Ser Asp Ser Asp 
            100                 105                 110         


Asp Asp Pro Leu Glu Ala Phe Met Ala Glu Val Glu Asp Gln Ala Ala 
        115                 120                 125             


Arg Asp Met Lys Arg Leu Glu Glu Lys Asp Lys Glu Arg Lys Asn Val 
    130                 135                 140                 


Lys Gly Ile Arg Asp Asp Ile Glu Glu Glu Asp Asp Gln Glu Ala Tyr 
145                 150                 155                 160 


Phe Arg Tyr Met Ala Glu Asn Pro Thr Ala Gly Val Val Gln Glu Glu 
                165                 170                 175     


Glu Glu Asp Asn Leu Glu Tyr Asp Ser Asp Gly Asn Pro Ile Ala Pro 
            180                 185                 190         


Thr Lys Lys Ile Ile Asp Pro Leu Pro Pro Ile Asp His Ser Glu Ile 
        195                 200                 205             


Asp Tyr Pro Pro Phe Glu Lys Asn Phe Tyr Asn Glu His Glu Glu Ile 
    210                 215                 220                 


Thr Asn Leu Thr Pro Gln Gln Leu Ile Asp Leu Arg His Lys Leu Asn 
225                 230                 235                 240 


Leu Arg Val Ser Gly Ala Ala Pro Pro Arg Pro Gly Ser Ser Phe Ala 
                245                 250                 255     


His Phe Gly Phe Asp Glu Gln Leu Met His Gln Ile Arg Lys Ser Glu 
            260                 265                 270         


Tyr Thr Gln Pro Thr Pro Ile Gln Cys Gln Gly Val Pro Val Ala Leu 
        275                 280                 285             


Ser Gly Arg Asp Met Ile Gly Ile Ala Lys Thr Gly Ser Gly Lys Thr 
    290                 295                 300                 


Ala Ala Phe Ile Trp Pro Met Leu Ile His Ile Met Asp Gln Lys Glu 
305                 310                 315                 320 


Leu Glu Pro Gly Asp Gly Pro Ile Ala Val Ile Val Cys Pro Thr Arg 
                325                 330                 335     


Glu Leu Cys Gln Gln Ile His Ala Glu Cys Lys Arg Phe Gly Lys Ala 
            340                 345                 350         


Tyr Asn Leu Arg Ser Val Ala Val Tyr Gly Gly Gly Ser Met Trp Glu 
        355                 360                 365             


Gln Ala Lys Ala Leu Gln Glu Gly Ala Glu Ile Val Val Cys Thr Pro 
    370                 375                 380                 


Gly Arg Leu Ile Asp His Val Lys Lys Lys Ala Thr Asn Leu Gln Arg 
385                 390                 395                 400 


Val Ser Tyr Leu Val Phe Asp Glu Ala Asp Arg Met Phe Asp Met Gly 
                405                 410                 415     


Phe Glu Tyr Gln Val Arg Ser Ile Ala Ser His Val Arg Pro Asp Arg 
            420                 425                 430         


Gln Thr Leu Leu Phe Ser Ala Thr Phe Arg Lys Lys Ile Glu Lys Leu 
        435                 440                 445             


Ala Arg Asp Ile Leu Ile Asp Pro Ile Arg Val Val Gln Gly Asp Ile 
    450                 455                 460                 


Gly Glu Ala Asn Glu Asp Val Thr Gln Ile Val Glu Ile Leu His Ser 
465                 470                 475                 480 


Gly Pro Ser Lys Trp Asn Trp Leu Thr Arg Arg Leu Val Glu Phe Thr 
                485                 490                 495     


Ser Ser Gly Ser Val Leu Leu Phe Val Thr Lys Lys Ala Asn Ala Glu 
            500                 505                 510         


Glu Leu Ala Asn Asn Leu Lys Gln Glu Gly His Asn Leu Gly Leu Leu 
        515                 520                 525             


His Gly Asp Met Asp Gln Ser Glu Arg Asn Lys Val Ile Ser Asp Phe 
    530                 535                 540                 


Lys Lys Lys Asp Ile Pro Val Leu Val Ala Thr Asp Val Ala Ala Arg 
545                 550                 555                 560 


Gly Leu Asp Ile Pro Ser Ile Lys Thr Val Ile Asn Tyr Asp Val Ala 
                565                 570                 575     


Arg Asp Ile Asp Thr His Thr His Arg Ile Gly Arg Thr Gly Arg Ala 
            580                 585                 590         


Gly Glu Lys Gly Val Ala Tyr Thr Leu Leu Thr Pro Lys Asp Ser Asn 
        595                 600                 605             


Phe Ala Gly Asp Leu Val Arg Asn Leu Glu Gly Ala Asn Gln His Val 
    610                 615                 620                 


Ser Lys Glu Leu Leu Asp Leu Ala Met Gln Asn Ala Trp Phe Arg Lys 
625                 630                 635                 640 


Ser Arg Phe Lys Gly Gly Lys Gly Lys Lys Leu Asn Ile Gly Gly Gly 
                645                 650                 655     


Gly Leu Gly Tyr Arg Glu Arg Pro Gly Leu Gly Ser Glu Asn Met Asp 
            660                 665                 670         


Arg Gly Asn Asn Asn Val Met Ser Asn Tyr Glu Ala Tyr Lys Pro Ser 
        675                 680                 685             


Thr Gly Ala Met Gly Asp Arg Leu Thr Ala Met Lys Ala Ala Phe Gln 
    690                 695                 700                 


Ser Gln Tyr Lys Ser His Phe Val Ala Ala Ser Leu Ser Asn Gln Lys 
705                 710                 715                 720 


Ala Gly Ser Ser Ala Ala Gly Ala Ser Gly Trp Thr Ser Ala Gly Ser 
                725                 730                 735     


Leu Asn Ser Val Pro Thr Asn Ser Ala Gln Gln Gly His Asn Ser Pro 
            740                 745                 750         


Asp Ser Pro Val Thr Ser Ala Ala Lys Gly Ile Pro Gly Phe Gly Asn 
        755                 760                 765             


Thr Gly Asn Ile Ser Gly Ala Pro Val Thr Tyr Pro Ser Ala Gly Ala 
    770                 775                 780                 


Gln Gly Val Asn Asn Thr Ala Ser Gly Asn Asn Ser Arg Glu Gly Thr 
785                 790                 795                 800 


Gly Gly Ser Asn Gly Lys Arg Glu Arg Tyr Thr Glu Asn Arg Gly Ser 
                805                 810                 815     


Ser Arg His Ser His Gly Glu Thr Gly Asn Arg His Ser Asp Ser Pro 
            820                 825                 830         


Arg His Gly Asp Gly Gly Arg His Gly Asp Gly Tyr Arg His Pro Glu 
        835                 840                 845             


Ser Ser Ser Arg His Thr Asp Gly His Arg His Gly Glu Asn Arg His 
    850                 855                 860                 


Gly Gly Ser Ala Gly Arg His Gly Glu Asn Arg Gly Ala Asn Asp Gly 
865                 870                 875                 880 


Arg Asn Gly Glu Ser Arg Lys Glu Ala Phe Asn Arg Glu Ser Lys Met 
                885                 890                 895     


Glu Pro Lys Met Glu Pro Lys Val Asp Ser Ser Lys Met Asp Lys Val 
            900                 905                 910         


Asp Ser Lys Thr Asp Lys Thr Ala Asp Gly Phe Ala Val Pro Glu Pro 
        915                 920                 925             


Pro Lys Arg Lys Lys Ser Arg Trp Asp Ser 
    930                 935             


<210>  2971
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX43__Homo_sapiens__NP_061135

<400>  2971

Met Ser His His Gly Gly Ala Pro Lys Ala Ser Thr Trp Val Val Ala 
1               5                   10                  15      


Ser Arg Arg Ser Ser Thr Val Ser Arg Ala Pro Glu Arg Arg Pro Ala 
            20                  25                  30          


Glu Glu Leu Asn Arg Thr Gly Pro Glu Gly Tyr Ser Val Gly Arg Gly 
        35                  40                  45              


Gly Arg Trp Arg Gly Thr Ser Arg Pro Pro Glu Ala Val Ala Ala Gly 
    50                  55                  60                  


His Glu Glu Leu Pro Leu Cys Phe Ala Leu Lys Ser His Phe Val Gly 
65                  70                  75                  80  


Ala Val Ile Gly Arg Gly Gly Ser Lys Ile Lys Asn Ile Gln Ser Thr 
                85                  90                  95      


Thr Asn Thr Thr Ile Gln Ile Ile Gln Glu Gln Pro Glu Ser Leu Val 
            100                 105                 110         


Lys Ile Phe Gly Ser Lys Ala Met Gln Thr Lys Ala Lys Ala Val Ile 
        115                 120                 125             


Asp Asn Phe Val Lys Lys Leu Glu Glu Asn Tyr Asn Ser Glu Cys Gly 
    130                 135                 140                 


Ile Asp Thr Ala Phe Gln Pro Ser Val Gly Lys Asp Gly Ser Thr Asp 
145                 150                 155                 160 


Asn Asn Val Val Ala Gly Asp Arg Pro Leu Ile Asp Trp Asp Gln Ile 
                165                 170                 175     


Arg Glu Glu Gly Leu Lys Trp Gln Lys Thr Lys Trp Ala Asp Leu Pro 
            180                 185                 190         


Pro Ile Lys Lys Asn Phe Tyr Lys Glu Ser Thr Ala Thr Ser Ala Met 
        195                 200                 205             


Ser Lys Val Glu Ala Asp Ser Trp Arg Lys Glu Asn Phe Asn Ile Thr 
    210                 215                 220                 


Trp Asp Asp Leu Lys Asp Gly Glu Lys Arg Pro Ile Pro Asn Pro Thr 
225                 230                 235                 240 


Cys Thr Phe Asp Asp Ala Phe Gln Cys Tyr Pro Glu Val Met Glu Asn 
                245                 250                 255     


Ile Lys Lys Ala Gly Phe Gln Lys Pro Thr Pro Ile Gln Ser Gln Ala 
            260                 265                 270         


Trp Pro Ile Val Leu Gln Gly Ile Asp Leu Ile Gly Val Ala Gln Thr 
        275                 280                 285             


Gly Thr Gly Lys Thr Leu Cys Tyr Leu Met Pro Gly Phe Ile His Leu 
    290                 295                 300                 


Val Leu Gln Pro Ser Leu Lys Gly Gln Arg Asn Arg Pro Gly Met Leu 
305                 310                 315                 320 


Val Leu Thr Pro Thr Arg Glu Leu Ala Leu Gln Val Glu Gly Glu Cys 
                325                 330                 335     


Cys Lys Tyr Ser Tyr Lys Gly Leu Arg Ser Val Cys Val Tyr Gly Gly 
            340                 345                 350         


Gly Asn Arg Asp Glu Gln Ile Glu Glu Leu Lys Lys Gly Val Asp Ile 
        355                 360                 365             


Ile Ile Ala Thr Pro Gly Arg Leu Asn Asp Leu Gln Met Ser Asn Phe 
    370                 375                 380                 


Val Asn Leu Lys Asn Ile Thr Tyr Leu Val Leu Asp Glu Ala Asp Lys 
385                 390                 395                 400 


Met Leu Asp Met Gly Phe Glu Pro Gln Ile Met Lys Ile Leu Leu Asp 
                405                 410                 415     


Val Arg Pro Asp Arg Gln Thr Val Met Thr Ser Ala Thr Trp Pro His 
            420                 425                 430         


Ser Val His Arg Leu Ala Gln Ser Tyr Leu Lys Glu Pro Met Ile Val 
        435                 440                 445             


Tyr Val Gly Thr Leu Asp Leu Val Ala Val Ser Ser Val Lys Gln Asn 
    450                 455                 460                 


Ile Ile Val Thr Thr Glu Glu Glu Lys Trp Ser His Met Gln Thr Phe 
465                 470                 475                 480 


Leu Gln Ser Met Ser Ser Thr Asp Lys Val Ile Val Phe Val Ser Arg 
                485                 490                 495     


Lys Ala Val Ala Asp His Leu Ser Ser Asp Leu Ile Leu Gly Asn Ile 
            500                 505                 510         


Ser Val Glu Ser Leu His Gly Asp Arg Glu Gln Arg Asp Arg Glu Lys 
        515                 520                 525             


Ala Leu Glu Asn Phe Lys Thr Gly Lys Val Arg Ile Leu Ile Ala Thr 
    530                 535                 540                 


Asp Leu Ala Ser Arg Gly Leu Asp Val His Asp Val Thr His Val Tyr 
545                 550                 555                 560 


Asn Phe Asp Phe Pro Arg Asn Ile Glu Glu Tyr Val His Arg Ile Gly 
                565                 570                 575     


Arg Thr Gly Arg Ala Gly Arg Thr Gly Val Ser Ile Thr Thr Leu Thr 
            580                 585                 590         


Arg Asn Asp Trp Arg Val Ala Ser Glu Leu Ile Asn Ile Leu Glu Arg 
        595                 600                 605             


Ala Asn Gln Ser Ile Pro Glu Glu Leu Val Ser Met Ala Glu Arg Phe 
    610                 615                 620                 


Lys Ala His Gln Gln Lys Arg Glu Met Glu Arg Lys Met Glu Arg Pro 
625                 630                 635                 640 


Gln Gly Arg Pro Lys Lys Phe His 
                645             


<210>  2972
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX46__Homo_sapiens__NP_001287789

<400>  2972

Met Gly Arg Glu Ser Arg His Tyr Arg Lys Arg Ser Ala Ser Arg Gly 
1               5                   10                  15      


Arg Ser Gly Ser Arg Ser Arg Ser Arg Ser Pro Ser Asp Lys Arg Ser 
            20                  25                  30          


Lys Arg Gly Asp Asp Arg Arg Ser Arg Ser Arg Asp Arg Asp Arg Arg 
        35                  40                  45              


Arg Glu Arg Ser Arg Ser Arg Asp Lys Arg Arg Ser Arg Ser Arg Asp 
    50                  55                  60                  


Arg Lys Arg Leu Arg Arg Ser Arg Ser Arg Glu Arg Asp Arg Ser Arg 
65                  70                  75                  80  


Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser Arg 
                85                  90                  95      


Ser Arg Gly Arg Arg Ser Arg Ser Ser Ser Pro Gly Asn Lys Ser Lys 
            100                 105                 110         


Lys Thr Glu Asn Arg Ser Arg Ser Lys Glu Lys Thr Asp Gly Gly Glu 
        115                 120                 125             


Ser Ser Lys Glu Lys Lys Lys Asp Lys Asp Asp Lys Glu Asp Glu Lys 
    130                 135                 140                 


Glu Lys Asp Ala Gly Asn Phe Asp Gln Asn Lys Leu Glu Glu Glu Met 
145                 150                 155                 160 


Arg Lys Arg Lys Glu Arg Val Glu Lys Trp Arg Glu Glu Gln Arg Lys 
                165                 170                 175     


Lys Ala Met Glu Asn Ile Gly Glu Leu Lys Lys Glu Ile Glu Glu Met 
            180                 185                 190         


Lys Gln Gly Lys Lys Trp Ser Leu Glu Asp Asp Asp Asp Asp Glu Asp 
        195                 200                 205             


Asp Pro Ala Glu Ala Glu Lys Glu Gly Asn Glu Met Glu Gly Glu Glu 
    210                 215                 220                 


Leu Asp Pro Leu Asp Ala Tyr Met Glu Glu Val Lys Glu Glu Val Lys 
225                 230                 235                 240 


Lys Phe Asn Met Arg Ser Val Lys Gly Gly Gly Gly Asn Glu Lys Lys 
                245                 250                 255     


Ser Gly Pro Thr Val Thr Lys Val Val Thr Val Val Thr Thr Lys Lys 
            260                 265                 270         


Ala Val Val Asp Ser Asp Lys Lys Lys Gly Glu Leu Met Glu Asn Asp 
        275                 280                 285             


Gln Asp Ala Met Glu Tyr Ser Ser Glu Glu Glu Glu Val Asp Leu Gln 
    290                 295                 300                 


Thr Ala Leu Thr Gly Tyr Gln Thr Lys Gln Arg Lys Leu Leu Glu Pro 
305                 310                 315                 320 


Val Asp His Gly Lys Ile Glu Tyr Glu Pro Phe Arg Lys Asn Phe Tyr 
                325                 330                 335     


Val Glu Val Pro Glu Leu Ala Lys Met Ser Gln Glu Glu Val Asn Val 
            340                 345                 350         


Phe Arg Leu Glu Met Glu Gly Ile Thr Val Lys Gly Lys Gly Cys Pro 
        355                 360                 365             


Lys Pro Ile Lys Ser Trp Val Gln Cys Gly Ile Ser Met Lys Ile Leu 
    370                 375                 380                 


Asn Ser Leu Lys Lys His Gly Tyr Glu Lys Pro Thr Pro Ile Gln Thr 
385                 390                 395                 400 


Gln Ala Ile Pro Ala Ile Met Ser Gly Arg Asp Leu Ile Gly Ile Ala 
                405                 410                 415     


Lys Thr Gly Ser Gly Lys Thr Ile Ala Phe Leu Leu Pro Met Phe Arg 
            420                 425                 430         


His Ile Met Asp Gln Arg Ser Leu Glu Glu Gly Glu Gly Pro Ile Ala 
        435                 440                 445             


Val Ile Met Thr Pro Thr Arg Glu Leu Ala Leu Gln Ile Thr Lys Glu 
    450                 455                 460                 


Cys Lys Lys Phe Ser Lys Thr Leu Gly Leu Arg Val Val Cys Val Tyr 
465                 470                 475                 480 


Gly Gly Thr Gly Ile Ser Glu Gln Ile Ala Glu Leu Lys Arg Gly Ala 
                485                 490                 495     


Glu Ile Ile Val Cys Thr Pro Gly Arg Met Ile Asp Met Leu Ala Ala 
            500                 505                 510         


Asn Ser Gly Arg Val Thr Asn Leu Arg Arg Val Thr Tyr Val Val Leu 
        515                 520                 525             


Asp Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Pro Gln Val Met 
    530                 535                 540                 


Arg Ile Val Asp Asn Val Arg Pro Asp Arg Gln Thr Val Met Phe Ser 
545                 550                 555                 560 


Ala Thr Phe Pro Arg Ala Met Glu Ala Leu Ala Arg Arg Ile Leu Ser 
                565                 570                 575     


Lys Pro Ile Glu Val Gln Val Gly Gly Arg Ser Val Val Cys Ser Asp 
            580                 585                 590         


Val Glu Gln Gln Val Ile Val Ile Glu Glu Glu Lys Lys Phe Leu Lys 
        595                 600                 605             


Leu Leu Glu Leu Leu Gly His Tyr Gln Glu Ser Gly Ser Val Ile Ile 
    610                 615                 620                 


Phe Val Asp Lys Gln Glu His Ala Asp Gly Leu Leu Lys Asp Leu Met 
625                 630                 635                 640 


Arg Ala Ser Tyr Pro Cys Met Ser Leu His Gly Gly Ile Asp Gln Tyr 
                645                 650                 655     


Asp Arg Asp Ser Ile Ile Asn Asp Phe Lys Asn Gly Thr Cys Lys Leu 
            660                 665                 670         


Leu Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Val Lys His Leu 
        675                 680                 685             


Ile Leu Val Val Asn Tyr Ser Cys Pro Asn His Tyr Glu Asp Tyr Val 
    690                 695                 700                 


His Arg Ala Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Tyr Ala Tyr 
705                 710                 715                 720 


Thr Phe Ile Thr Glu Asp Gln Ala Arg Tyr Ala Gly Asp Ile Ile Lys 
                725                 730                 735     


Ala Leu Glu Leu Ser Gly Thr Ala Val Pro Pro Asp Leu Glu Lys Leu 
            740                 745                 750         


Trp Ser Asp Phe Lys Asp Gln Gln Lys Ala Glu Gly Lys Ile Ile Lys 
        755                 760                 765             


Lys Ser Ser Gly Phe Ser Gly Lys Gly Phe Lys Phe Asp Glu Thr Glu 
    770                 775                 780                 


Gln Ala Leu Ala Asn Glu Arg Lys Lys Leu Gln Lys Ala Ala Leu Gly 
785                 790                 795                 800 


Leu Gln Asp Ser Asp Asp Glu Asp Ala Ala Val Asp Ile Asp Glu Gln 
                805                 810                 815     


Ile Glu Ser Met Phe Asn Ser Lys Lys Arg Val Lys Asp Met Ala Ala 
            820                 825                 830         


Pro Gly Thr Ser Ser Val Pro Ala Pro Thr Ala Gly Asn Ala Glu Lys 
        835                 840                 845             


Leu Glu Ile Ala Lys Arg Leu Ala Leu Arg Ile Asn Ala Gln Lys Asn 
    850                 855                 860                 


Leu Gly Ile Glu Ser Gln Val Asp Val Met Gln Gln Ala Thr Asn Ala 
865                 870                 875                 880 


Ile Leu Arg Gly Gly Thr Ile Leu Ala Pro Thr Val Ser Ala Lys Thr 
                885                 890                 895     


Ile Ala Glu Gln Leu Ala Glu Lys Ile Asn Ala Lys Leu Asn Tyr Val 
            900                 905                 910         


Pro Leu Glu Lys Gln Glu Glu Glu Arg Gln Asp Gly Gly Gln Asn Glu 
        915                 920                 925             


Ser Phe Lys Arg Tyr Glu Glu Glu Leu Glu Ile Asn Asp Phe Pro Gln 
    930                 935                 940                 


Thr Ala Arg Trp Lys Val Thr Ser Lys Glu Ala Leu Gln Arg Ile Ser 
945                 950                 955                 960 


Glu Tyr Ser Glu Ala Ala Ile Thr Ile Arg Gly Thr Tyr Phe Pro Pro 
                965                 970                 975     


Gly Lys Glu Pro Lys Glu Gly Glu Arg Lys Ile Tyr Leu Ala Ile Glu 
            980                 985                 990         


Ser Ala Asn Glu Leu Ala Val Gln  Lys Ala Lys Ala Glu  Ile Thr Arg 
        995                 1000                 1005             


Leu Ile  Lys Glu Glu Leu Ile  Arg Leu Gln Asn Ser  Tyr Gln Pro 
    1010                 1015                 1020             


Thr Asn  Lys Gly Arg Tyr Lys  Val Leu 
    1025                 1030         


<210>  2973
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX4__Homo_sapiens__NP_001136021

<400>  2973

Met Gly Asp Glu Asp Trp Glu Ala Glu Ile Asn Pro His Met Ser Ser 
1               5                   10                  15      


Tyr Val Pro Ile Phe Glu Lys Asp Arg Tyr Ser Gly Glu Asn Gly Asp 
            20                  25                  30          


Asn Phe Asn Arg Thr Pro Ala Ser Ser Ser Glu Met Asp Asp Gly Pro 
        35                  40                  45              


Ser Arg Arg Asp His Phe Met Lys Ser Gly Phe Ala Ser Gly Arg Asn 
    50                  55                  60                  


Phe Gly Asn Arg Asp Ala Gly Glu Cys Asn Lys Arg Asp Asn Thr Ser 
65                  70                  75                  80  


Thr Met Gly Gly Phe Gly Val Gly Lys Ser Phe Gly Asn Arg Gly Phe 
                85                  90                  95      


Ser Asn Ser Arg Phe Glu Asp Gly Asp Ser Ser Gly Phe Trp Arg Glu 
            100                 105                 110         


Ser Ser Asn Asp Cys Glu Asp Asn Pro Thr Arg Asn Arg Gly Phe Ser 
        115                 120                 125             


Lys Arg Gly Asp Asn Asp Leu Asp Pro Asp Glu Cys Met Gln Arg Thr 
    130                 135                 140                 


Gly Gly Leu Phe Gly Ser Arg Arg Pro Val Leu Ser Gly Thr Gly Asn 
145                 150                 155                 160 


Gly Asp Thr Ser Gln Ser Arg Ser Gly Ser Gly Ser Glu Arg Gly Gly 
                165                 170                 175     


Tyr Lys Gly Leu Asn Glu Glu Val Ile Thr Gly Ser Gly Lys Asn Ser 
            180                 185                 190         


Trp Lys Ser Glu Ala Glu Gly Gly Glu Ser Ser Asp Thr Gln Gly Pro 
        195                 200                 205             


Lys Val Thr Tyr Ile Pro Pro Pro Pro Pro Glu Asp Glu Asp Ser Ile 
    210                 215                 220                 


Phe Ala His Tyr Gln Thr Gly Ile Asn Phe Asp Lys Tyr Asp Thr Ile 
225                 230                 235                 240 


Leu Val Glu Val Ser Gly His Asp Ala Pro Pro Ala Ile Leu Thr Phe 
                245                 250                 255     


Glu Glu Ala Asn Leu Cys Gln Thr Leu Asn Asn Asn Ile Ala Lys Ala 
            260                 265                 270         


Gly Tyr Thr Lys Leu Thr Pro Val Gln Lys Tyr Ser Ile Pro Ile Ile 
        275                 280                 285             


Leu Ala Gly Arg Asp Leu Met Ala Cys Ala Gln Thr Gly Ser Gly Lys 
    290                 295                 300                 


Thr Ala Ala Phe Leu Leu Pro Ile Leu Ala His Met Met His Asp Gly 
305                 310                 315                 320 


Ile Thr Ala Ser Arg Phe Lys Glu Leu Gln Glu Pro Glu Cys Ile Ile 
                325                 330                 335     


Val Ala Pro Thr Arg Glu Leu Val Asn Gln Ile Tyr Leu Glu Ala Arg 
            340                 345                 350         


Lys Phe Ser Phe Gly Thr Cys Val Arg Ala Val Val Ile Tyr Gly Gly 
        355                 360                 365             


Thr Gln Leu Gly His Ser Ile Arg Gln Ile Val Gln Gly Cys Asn Ile 
    370                 375                 380                 


Leu Cys Ala Thr Pro Gly Arg Leu Met Asp Ile Ile Gly Lys Glu Lys 
385                 390                 395                 400 


Ile Gly Leu Lys Gln Ile Lys Tyr Leu Val Leu Asp Glu Ala Asp Arg 
                405                 410                 415     


Met Leu Asp Met Gly Phe Gly Pro Glu Met Lys Lys Leu Ile Ser Cys 
            420                 425                 430         


Pro Gly Met Pro Ser Lys Glu Gln Arg Gln Thr Leu Met Phe Ser Ala 
        435                 440                 445             


Thr Phe Pro Glu Glu Ile Gln Arg Leu Ala Ala Glu Phe Leu Lys Ser 
    450                 455                 460                 


Asn Tyr Leu Phe Val Ala Val Gly Gln Val Gly Gly Ala Cys Arg Asp 
465                 470                 475                 480 


Val Gln Gln Thr Val Leu Gln Val Gly Gln Phe Ser Lys Arg Glu Lys 
                485                 490                 495     


Leu Val Glu Ile Leu Arg Asn Ile Gly Asp Glu Arg Thr Met Val Phe 
            500                 505                 510         


Val Glu Thr Lys Lys Lys Ala Asp Phe Ile Ala Thr Phe Leu Cys Gln 
        515                 520                 525             


Glu Lys Ile Ser Thr Thr Ser Ile His Gly Asp Arg Glu Gln Arg Glu 
    530                 535                 540                 


Arg Glu Gln Ala Leu Gly Asp Phe Arg Phe Gly Lys Cys Pro Val Leu 
545                 550                 555                 560 


Val Ala Thr Ser Val Ala Ala Arg Gly Leu Asp Ile Glu Asn Val Gln 
                565                 570                 575     


His Val Ile Asn Phe Asp Leu Pro Ser Thr Ile Asp Glu Tyr Val His 
            580                 585                 590         


Arg Ile Gly Arg Thr Gly Arg Cys Gly Asn Thr Gly Arg Ala Ile Ser 
        595                 600                 605             


Phe Phe Asp Leu Glu Ser Asp Asn His Leu Ala Gln Pro Leu Val Lys 
    610                 615                 620                 


Val Leu Thr Asp Ala Gln Gln Asp Val Pro Ala Trp Leu Glu Glu Ile 
625                 630                 635                 640 


Ala Phe Ser Thr Tyr Ile Pro Gly Phe Ser Gly Ser Thr Arg Gly Asn 
                645                 650                 655     


Val Phe Ala Ser Val Asp Thr Arg Lys Gly Lys Ser Thr Leu Asn Thr 
            660                 665                 670         


Ala Gly Phe Ser Ser Ser Gln Ala Pro Asn Pro Val Asp Asp Glu Ser 
        675                 680                 685             


Trp Asp 
    690 


<210>  2974
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX50__Homo_sapiens__NP_076950

<400>  2974

Met Pro Gly Lys Leu Leu Trp Gly Asp Ile Met Glu Leu Glu Ala Pro 
1               5                   10                  15      


Leu Glu Glu Ser Glu Ser Gln Lys Lys Glu Arg Gln Lys Ser Asp Arg 
            20                  25                  30          


Arg Lys Ser Arg His His Tyr Asp Ser Asp Glu Lys Ser Glu Thr Arg 
        35                  40                  45              


Glu Asn Gly Val Thr Asp Asp Leu Asp Ala Pro Lys Ala Lys Lys Ser 
    50                  55                  60                  


Lys Met Lys Glu Lys Leu Asn Gly Asp Thr Glu Glu Gly Phe Asn Arg 
65                  70                  75                  80  


Leu Ser Asp Glu Phe Ser Lys Ser His Lys Ser Arg Arg Lys Asp Leu 
                85                  90                  95      


Pro Asn Gly Asp Ile Asp Glu Tyr Glu Lys Lys Ser Lys Arg Val Ser 
            100                 105                 110         


Ser Leu Asp Thr Ser Thr His Lys Ser Ser Asp Asn Lys Leu Glu Glu 
        115                 120                 125             


Thr Leu Thr Arg Glu Gln Lys Glu Gly Ala Phe Ser Asn Phe Pro Ile 
    130                 135                 140                 


Ser Glu Glu Thr Ile Lys Leu Leu Lys Gly Arg Gly Val Thr Tyr Leu 
145                 150                 155                 160 


Phe Pro Ile Gln Val Lys Thr Phe Gly Pro Val Tyr Glu Gly Lys Asp 
                165                 170                 175     


Leu Ile Ala Gln Ala Arg Thr Gly Thr Gly Lys Thr Phe Ser Phe Ala 
            180                 185                 190         


Ile Pro Leu Ile Glu Arg Leu Gln Arg Asn Gln Glu Thr Ile Lys Lys 
        195                 200                 205             


Ser Arg Ser Pro Lys Val Leu Val Leu Ala Pro Thr Arg Glu Leu Ala 
    210                 215                 220                 


Asn Gln Val Ala Lys Asp Phe Lys Asp Ile Thr Arg Lys Leu Ser Val 
225                 230                 235                 240 


Ala Cys Phe Tyr Gly Gly Thr Ser Tyr Gln Ser Gln Ile Asn His Ile 
                245                 250                 255     


Arg Asn Gly Ile Asp Ile Leu Val Gly Thr Pro Gly Arg Ile Lys Asp 
            260                 265                 270         


His Leu Gln Ser Gly Arg Leu Asp Leu Ser Lys Leu Arg His Val Val 
        275                 280                 285             


Leu Asp Glu Val Asp Gln Met Leu Asp Leu Gly Phe Ala Glu Gln Val 
    290                 295                 300                 


Glu Asp Ile Ile His Glu Ser Tyr Lys Thr Asp Ser Glu Asp Asn Pro 
305                 310                 315                 320 


Gln Thr Leu Leu Phe Ser Ala Thr Cys Pro Gln Trp Val Tyr Lys Val 
                325                 330                 335     


Ala Lys Lys Tyr Met Lys Ser Arg Tyr Glu Gln Val Asp Leu Val Gly 
            340                 345                 350         


Lys Met Thr Gln Lys Ala Ala Thr Thr Val Glu His Leu Ala Ile Gln 
        355                 360                 365             


Cys His Trp Ser Gln Arg Pro Ala Val Ile Gly Asp Val Leu Gln Val 
    370                 375                 380                 


Tyr Ser Gly Ser Glu Gly Arg Ala Ile Ile Phe Cys Glu Thr Lys Lys 
385                 390                 395                 400 


Asn Val Thr Glu Met Ala Met Asn Pro His Ile Lys Gln Asn Ala Gln 
                405                 410                 415     


Cys Leu His Gly Asp Ile Ala Gln Ser Gln Arg Glu Ile Thr Leu Lys 
            420                 425                 430         


Gly Phe Arg Glu Gly Ser Phe Lys Val Leu Val Ala Thr Asn Val Ala 
        435                 440                 445             


Ala Arg Gly Leu Asp Ile Pro Glu Val Asp Leu Val Ile Gln Ser Ser 
    450                 455                 460                 


Pro Pro Gln Asp Val Glu Ser Tyr Ile His Arg Ser Gly Arg Thr Gly 
465                 470                 475                 480 


Arg Ala Gly Arg Thr Gly Ile Cys Ile Cys Phe Tyr Gln Pro Arg Glu 
                485                 490                 495     


Arg Gly Gln Leu Arg Tyr Val Glu Gln Lys Ala Gly Ile Thr Phe Lys 
            500                 505                 510         


Arg Val Gly Val Pro Ser Thr Met Asp Leu Val Lys Ser Lys Ser Met 
        515                 520                 525             


Asp Ala Ile Arg Ser Leu Ala Ser Val Ser Tyr Ala Ala Val Asp Phe 
    530                 535                 540                 


Phe Arg Pro Ser Ala Gln Arg Leu Ile Glu Glu Lys Gly Ala Val Asp 
545                 550                 555                 560 


Ala Leu Ala Ala Ala Leu Ala His Ile Ser Gly Ala Ser Ser Phe Glu 
                565                 570                 575     


Pro Arg Ser Leu Ile Thr Ser Asp Lys Gly Phe Val Thr Met Thr Leu 
            580                 585                 590         


Glu Ser Leu Glu Glu Ile Gln Asp Val Ser Cys Ala Trp Lys Glu Leu 
        595                 600                 605             


Asn Arg Lys Leu Ser Ser Asn Ala Val Ser Gln Ile Thr Arg Met Cys 
    610                 615                 620                 


Leu Leu Lys Gly Asn Met Gly Val Cys Phe Asp Val Pro Thr Thr Glu 
625                 630                 635                 640 


Ser Glu Arg Leu Gln Ala Glu Trp His Asp Ser Asp Trp Ile Leu Ser 
                645                 650                 655     


Val Pro Ala Lys Leu Pro Glu Ile Glu Glu Tyr Tyr Asp Gly Asn Thr 
            660                 665                 670         


Ser Ser Asn Ser Arg Gln Arg Ser Gly Trp Ser Ser Gly Arg Ser Gly 
        675                 680                 685             


Arg Ser Gly Arg Ser Gly Gly Arg Ser Gly Gly Arg Ser Gly Arg Gln 
    690                 695                 700                 


Ser Arg Gln Gly Ser Arg Ser Gly Ser Arg Gln Asp Gly Arg Arg Arg 
705                 710                 715                 720 


Ser Gly Asn Arg Asn Arg Ser Arg Ser Gly Gly His Lys Arg Ser Phe 
                725                 730                 735     


Asp 
    


<210>  2975
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX51__Homo_sapiens__NP_778236

<400>  2975

Met Ala Leu Phe Tyr Val Ala Arg Tyr Pro Gly Pro Asp Ala Ala Ala 
1               5                   10                  15      


Ala Ala Gly Pro Glu Gly Ala Glu Ala Gly Ala His Gly Arg Ala Arg 
            20                  25                  30          


Ala Leu Leu Glu Arg Leu Gln Ser Arg Ala Arg Glu Arg Gln Gln Gln 
        35                  40                  45              


Arg Glu Pro Ala Gln Thr Glu Ala Ala Ala Ser Thr Glu Pro Ala Thr 
    50                  55                  60                  


Arg Arg Arg Arg Arg Pro Arg Arg Arg Arg Arg Val Asn Asp Ala Glu 
65                  70                  75                  80  


Pro Gly Ser Pro Glu Ala Pro Gln Gly Lys Arg Arg Lys Ala Asp Gly 
                85                  90                  95      


Glu Asp Ala Gly Ala Glu Ser Asn Glu Glu Ala Pro Gly Glu Pro Ser 
            100                 105                 110         


Ala Gly Ser Ser Glu Glu Ala Pro Gly Glu Pro Ser Ala Gly Ser Ser 
        115                 120                 125             


Glu Glu Ala Pro Gly Glu Arg Ser Thr Ser Ala Ser Ala Glu Ala Ala 
    130                 135                 140                 


Pro Asp Gly Pro Ala Leu Glu Glu Ala Ala Gly Pro Leu Val Pro Gly 
145                 150                 155                 160 


Leu Val Leu Gly Gly Phe Gly Lys Arg Lys Ala Pro Lys Val Gln Pro 
                165                 170                 175     


Phe Leu Pro Arg Trp Leu Ala Glu Pro Asn Cys Val Arg Arg Asn Val 
            180                 185                 190         


Thr Glu Asp Leu Val Pro Ile Glu Asp Ile Pro Asp Val His Pro Asp 
        195                 200                 205             


Leu Gln Lys Gln Leu Arg Ala His Gly Ile Ser Ser Tyr Phe Pro Val 
    210                 215                 220                 


Gln Ala Ala Val Ile Pro Ala Leu Leu Glu Ser Ala Ala Cys Gly Phe 
225                 230                 235                 240 


Leu Val Gly Arg Gly Gly Tyr Arg Pro Ser Asp Leu Cys Val Ser Ala 
                245                 250                 255     


Pro Thr Gly Ser Gly Lys Thr Leu Ala Phe Val Ile Pro Val Val Gln 
            260                 265                 270         


Ala Leu Leu Ser Arg Val Val Cys His Ile Arg Ala Leu Val Val Leu 
        275                 280                 285             


Pro Thr Lys Glu Leu Ala Gln Gln Val Ser Lys Val Phe Asn Ile Tyr 
    290                 295                 300                 


Thr Asp Ala Thr Pro Leu Arg Val Ser Leu Val Thr Gly Gln Lys Ser 
305                 310                 315                 320 


Leu Ala Lys Glu Gln Glu Ser Leu Val Gln Lys Thr Ala Asp Gly Tyr 
                325                 330                 335     


Arg Cys Leu Ala Asp Ile Val Val Ala Thr Pro Gly Arg Leu Val Asp 
            340                 345                 350         


His Ile Asp Gln Thr Pro Gly Phe Ser Leu Gln Gln Leu Arg Phe Leu 
        355                 360                 365             


Ile Ile Asp Glu Ala Asp Arg Met Ile Asp Ser Met His Gln Ser Trp 
    370                 375                 380                 


Leu Pro Arg Val Val Ala Ala Ala Phe Gln Ser Glu Asp Pro Ala Asp 
385                 390                 395                 400 


Pro Cys Ala Leu Leu Gln Arg Arg Gln Ala Gln Ala Val Thr Ala Ala 
                405                 410                 415     


Ser Thr Cys Cys Pro Gln Met Pro Leu Gln Lys Leu Leu Phe Ser Ala 
            420                 425                 430         


Thr Leu Thr Gln Asn Pro Glu Lys Leu Gln Gln Leu Gly Leu His Gln 
        435                 440                 445             


Pro Arg Leu Phe Ser Thr Gly Leu Ala His Arg Gly Leu Glu Asp Thr 
    450                 455                 460                 


Asp Gly Asp Gly Asp Ser Gly Lys Tyr Ala Phe Pro Val Gly Leu Thr 
465                 470                 475                 480 


His His Tyr Val Pro Cys Ser Leu Ser Ser Lys Pro Leu Val Val Leu 
                485                 490                 495     


His Leu Val Leu Glu Met Gly Phe Ser Arg Val Leu Cys Phe Thr Asn 
            500                 505                 510         


Ser Arg Glu Asn Ser His Arg Leu Phe Leu Leu Val Gln Ala Phe Gly 
        515                 520                 525             


Gly Val Asp Val Ala Glu Phe Ser Ser Arg Tyr Gly Pro Gly Gln Arg 
    530                 535                 540                 


Arg Met Ile Leu Lys Gln Phe Glu Gln Gly Lys Ile Gln Leu Leu Ile 
545                 550                 555                 560 


Ser Thr Asp Ala Thr Ala Arg Gly Ile Asp Val Gln Gly Val Glu Leu 
                565                 570                 575     


Val Val Asn Tyr Asp Ala Pro Gln Tyr Leu Arg Thr Tyr Val His Arg 
            580                 585                 590         


Val Gly Arg Thr Ala Arg Ala Gly Lys Thr Gly Gln Ala Phe Thr Leu 
        595                 600                 605             


Leu Leu Lys Val Gln Glu Arg Arg Phe Leu Arg Met Leu Thr Glu Ala 
    610                 615                 620                 


Gly Ala Pro Glu Leu Gln Arg His Glu Leu Ser Ser Lys Leu Leu Gln 
625                 630                 635                 640 


Pro Leu Val Pro Arg Tyr Glu Glu Ala Leu Ser Gln Leu Glu Glu Ser 
                645                 650                 655     


Val Lys Glu Glu Arg Lys Gln Arg Ala Ala 
            660                 665     


<210>  2976
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX52__Homo_sapiens__NP_008941

<400>  2976

Met Asp Val His Asp Leu Phe Arg Arg Leu Gly Ala Gly Ala Lys Phe 
1               5                   10                  15      


Asp Thr Arg Arg Phe Ser Ala Asp Ala Ala Arg Phe Gln Ile Gly Lys 
            20                  25                  30          


Arg Lys Tyr Asp Phe Asp Ser Ser Glu Val Leu Gln Gly Leu Asp Phe 
        35                  40                  45              


Phe Gly Asn Lys Lys Ser Val Pro Gly Val Cys Gly Ala Ser Gln Thr 
    50                  55                  60                  


His Gln Lys Pro Gln Asn Gly Glu Lys Lys Glu Glu Ser Leu Thr Glu 
65                  70                  75                  80  


Arg Lys Arg Glu Gln Ser Lys Lys Lys Arg Lys Thr Met Thr Ser Glu 
                85                  90                  95      


Ile Ala Ser Gln Glu Glu Gly Ala Thr Ile Gln Trp Met Ser Ser Val 
            100                 105                 110         


Glu Ala Lys Ile Glu Asp Lys Lys Val Gln Arg Glu Ser Lys Leu Thr 
        115                 120                 125             


Ser Gly Lys Leu Glu Asn Leu Arg Lys Glu Lys Ile Asn Phe Leu Arg 
    130                 135                 140                 


Asn Lys His Lys Ile His Val Gln Gly Thr Asp Leu Pro Asp Pro Ile 
145                 150                 155                 160 


Ala Thr Phe Gln Gln Leu Asp Gln Glu Tyr Lys Ile Asn Ser Arg Leu 
                165                 170                 175     


Leu Gln Asn Ile Leu Asp Ala Gly Phe Gln Met Pro Thr Pro Ile Gln 
            180                 185                 190         


Met Gln Ala Ile Pro Val Met Leu His Gly Arg Glu Leu Leu Ala Ser 
        195                 200                 205             


Ala Pro Thr Gly Ser Gly Lys Thr Leu Ala Phe Ser Ile Pro Ile Leu 
    210                 215                 220                 


Met Gln Leu Lys Gln Pro Ala Asn Lys Gly Phe Arg Ala Leu Ile Ile 
225                 230                 235                 240 


Ser Pro Thr Arg Glu Leu Ala Ser Gln Ile His Arg Glu Leu Ile Lys 
                245                 250                 255     


Ile Ser Glu Gly Thr Gly Phe Arg Ile His Met Ile His Lys Ala Ala 
            260                 265                 270         


Val Ala Ala Lys Lys Phe Gly Pro Lys Ser Ser Lys Lys Phe Asp Ile 
        275                 280                 285             


Leu Val Thr Thr Pro Asn Arg Leu Ile Tyr Leu Leu Lys Gln Asp Pro 
    290                 295                 300                 


Pro Gly Ile Asp Leu Ala Ser Val Glu Trp Leu Val Val Asp Glu Ser 
305                 310                 315                 320 


Asp Lys Leu Phe Glu Asp Gly Lys Thr Gly Phe Arg Asp Gln Leu Ala 
                325                 330                 335     


Ser Ile Phe Leu Ala Cys Thr Ser His Lys Val Arg Arg Ala Met Phe 
            340                 345                 350         


Ser Ala Thr Phe Ala Tyr Asp Val Glu Gln Trp Cys Lys Leu Asn Leu 
        355                 360                 365             


Asp Asn Val Ile Ser Val Ser Ile Gly Ala Arg Asn Ser Ala Val Glu 
    370                 375                 380                 


Thr Val Glu Gln Glu Leu Leu Phe Val Gly Ser Glu Thr Gly Lys Leu 
385                 390                 395                 400 


Leu Ala Val Arg Glu Leu Val Lys Lys Gly Phe Asn Pro Pro Val Leu 
                405                 410                 415     


Val Phe Val Gln Ser Ile Glu Arg Ala Lys Glu Leu Phe His Glu Leu 
            420                 425                 430         


Ile Tyr Glu Gly Ile Asn Val Asp Val Ile His Ala Glu Arg Thr Gln 
        435                 440                 445             


Gln Gln Arg Asp Asn Thr Val His Ser Phe Arg Ala Gly Lys Ile Trp 
    450                 455                 460                 


Val Leu Ile Cys Thr Ala Leu Leu Ala Arg Gly Ile Asp Phe Lys Gly 
465                 470                 475                 480 


Val Asn Leu Val Ile Asn Tyr Asp Phe Pro Thr Ser Ser Val Glu Tyr 
                485                 490                 495     


Ile His Arg Ile Gly Arg Thr Gly Arg Ala Gly Asn Lys Gly Lys Ala 
            500                 505                 510         


Ile Thr Phe Phe Thr Glu Asp Asp Lys Pro Leu Leu Arg Ser Val Ala 
        515                 520                 525             


Asn Val Ile Gln Gln Ala Gly Cys Pro Val Pro Glu Tyr Ile Lys Gly 
    530                 535                 540                 


Phe Gln Lys Leu Leu Ser Lys Gln Lys Lys Lys Met Ile Lys Lys Pro 
545                 550                 555                 560 


Leu Glu Arg Glu Ser Ile Ser Thr Thr Pro Lys Cys Phe Leu Glu Lys 
                565                 570                 575     


Ala Lys Asp Lys Gln Lys Lys Val Thr Gly Gln Asn Ser Lys Lys Lys 
            580                 585                 590         


Val Ala Leu Glu Asp Lys Ser 
        595                 


<210>  2977
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX53__Homo_sapiens__NP_874358

<400>  2977

Met Ser His Trp Ala Pro Glu Trp Lys Arg Ala Glu Ala Asn Pro Arg 
1               5                   10                  15      


Asp Leu Gly Ala Ser Trp Asp Val Arg Gly Ser Arg Gly Ser Gly Trp 
            20                  25                  30          


Ser Gly Pro Phe Gly His Gln Gly Pro Arg Ala Ala Gly Ser Arg Glu 
        35                  40                  45              


Pro Pro Leu Cys Phe Lys Ile Lys Asn Asn Met Val Gly Val Val Ile 
    50                  55                  60                  


Gly Tyr Ser Gly Ser Lys Ile Lys Asp Leu Gln His Ser Thr Asn Thr 
65                  70                  75                  80  


Lys Ile Gln Ile Ile Asn Gly Glu Ser Glu Ala Lys Val Arg Ile Phe 
                85                  90                  95      


Gly Asn Arg Glu Met Lys Ala Lys Ala Lys Ala Ala Ile Glu Thr Leu 
            100                 105                 110         


Ile Arg Lys Gln Glu Ser Tyr Asn Ser Glu Ser Ser Val Asp Asn Ala 
        115                 120                 125             


Ala Ser Gln Thr Pro Ile Gly Arg Asn Leu Gly Arg Asn Asp Ile Val 
    130                 135                 140                 


Gly Glu Ala Glu Pro Leu Ser Asn Trp Asp Arg Ile Arg Ala Ala Val 
145                 150                 155                 160 


Val Glu Cys Glu Lys Arg Lys Trp Ala Asp Leu Pro Pro Val Lys Lys 
                165                 170                 175     


Asn Phe Tyr Ile Glu Ser Lys Ala Thr Ser Cys Met Ser Glu Met Gln 
            180                 185                 190         


Val Ile Asn Trp Arg Lys Glu Asn Phe Asn Ile Thr Cys Asp Asp Leu 
        195                 200                 205             


Lys Ser Gly Glu Lys Arg Leu Ile Pro Lys Pro Thr Cys Arg Phe Lys 
    210                 215                 220                 


Asp Ala Phe Gln Gln Tyr Pro Asp Leu Leu Lys Ser Ile Ile Arg Val 
225                 230                 235                 240 


Gly Ile Val Lys Pro Thr Pro Ile Gln Ser Gln Ala Trp Pro Ile Ile 
                245                 250                 255     


Leu Gln Gly Ile Asp Leu Ile Val Val Ala Gln Thr Gly Thr Gly Lys 
            260                 265                 270         


Thr Leu Ser Tyr Leu Met Pro Gly Phe Ile His Leu Asp Ser Gln Pro 
        275                 280                 285             


Ile Ser Arg Glu Gln Arg Asn Gly Pro Gly Met Leu Val Leu Thr Pro 
    290                 295                 300                 


Thr Arg Glu Leu Ala Leu His Val Glu Ala Glu Cys Ser Lys Tyr Ser 
305                 310                 315                 320 


Tyr Lys Gly Leu Lys Ser Ile Cys Ile Tyr Gly Gly Arg Asn Arg Asn 
                325                 330                 335     


Gly Gln Ile Glu Asp Ile Ser Lys Gly Val Asp Ile Ile Ile Ala Thr 
            340                 345                 350         


Pro Gly Arg Leu Asn Asp Leu Gln Met Asn Asn Ser Val Asn Leu Arg 
        355                 360                 365             


Ser Ile Thr Tyr Leu Val Ile Asp Glu Ala Asp Lys Met Leu Asp Met 
    370                 375                 380                 


Glu Phe Glu Pro Gln Ile Arg Lys Ile Leu Leu Asp Val Arg Pro Asp 
385                 390                 395                 400 


Arg Gln Thr Val Met Thr Ser Ala Thr Trp Pro Asp Thr Val Arg Gln 
                405                 410                 415     


Leu Ala Leu Ser Tyr Leu Lys Asp Pro Met Ile Val Tyr Val Gly Asn 
            420                 425                 430         


Leu Asn Leu Val Ala Val Asn Thr Val Lys Gln Asn Ile Ile Val Thr 
        435                 440                 445             


Thr Glu Lys Glu Lys Arg Ala Leu Thr Gln Glu Phe Val Glu Asn Met 
    450                 455                 460                 


Ser Pro Asn Asp Lys Val Ile Met Phe Val Ser Gln Lys His Ile Ala 
465                 470                 475                 480 


Asp Asp Leu Ser Ser Asp Phe Asn Ile Gln Gly Ile Ser Ala Glu Ser 
                485                 490                 495     


Leu His Gly Asn Ser Glu Gln Ser Asp Gln Glu Arg Ala Val Glu Asp 
            500                 505                 510         


Phe Lys Ser Gly Asn Ile Lys Ile Leu Ile Thr Thr Asp Ile Val Ser 
        515                 520                 525             


Arg Gly Leu Asp Leu Asn Asp Val Thr His Val Tyr Asn Tyr Asp Phe 
    530                 535                 540                 


Pro Arg Asn Ile Asp Val Tyr Val His Arg Val Gly Tyr Ile Gly Arg 
545                 550                 555                 560 


Thr Gly Lys Thr Gly Thr Ser Val Thr Leu Ile Thr Gln Arg Asp Ser 
                565                 570                 575     


Lys Met Ala Gly Glu Leu Ile Lys Ile Leu Asp Arg Ala Asn Gln Ser 
            580                 585                 590         


Val Pro Glu Asp Leu Val Val Met Ala Glu Gln Tyr Lys Leu Asn Gln 
        595                 600                 605             


Gln Lys Arg His Arg Glu Thr Arg Ser Arg Lys Pro Gly Gln Arg Arg 
    610                 615                 620                 


Lys Glu Phe Tyr Phe Leu Ser 
625                 630     


<210>  2978
<211>  882
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX54__Homo_sapiens__NP_001104792

<400>  2978

Met Ala Ala Asp Lys Gly Pro Ala Ala Gly Pro Arg Ser Arg Ala Ala 
1               5                   10                  15      


Met Ala Gln Trp Arg Lys Lys Lys Gly Leu Arg Lys Arg Arg Gly Ala 
            20                  25                  30          


Ala Ser Gln Ala Arg Gly Ser Asp Ser Glu Asp Gly Glu Phe Glu Ile 
        35                  40                  45              


Gln Ala Glu Asp Asp Ala Arg Ala Arg Lys Leu Gly Pro Gly Arg Pro 
    50                  55                  60                  


Leu Pro Thr Phe Pro Thr Ser Glu Cys Thr Ser Asp Val Glu Pro Asp 
65                  70                  75                  80  


Thr Arg Glu Met Val Arg Ala Gln Asn Lys Lys Lys Lys Lys Ser Gly 
                85                  90                  95      


Gly Phe Gln Ser Met Gly Leu Ser Tyr Pro Val Phe Lys Gly Ile Met 
            100                 105                 110         


Lys Lys Gly Tyr Lys Val Pro Thr Pro Ile Gln Arg Lys Thr Ile Pro 
        115                 120                 125             


Val Ile Leu Asp Gly Lys Asp Val Val Ala Met Ala Arg Thr Gly Ser 
    130                 135                 140                 


Gly Lys Thr Ala Cys Phe Leu Leu Pro Met Phe Glu Arg Leu Lys Thr 
145                 150                 155                 160 


His Ser Ala Gln Thr Gly Ala Arg Ala Leu Ile Leu Ser Pro Thr Arg 
                165                 170                 175     


Glu Leu Ala Leu Gln Thr Leu Lys Phe Thr Lys Glu Leu Gly Lys Phe 
            180                 185                 190         


Thr Gly Leu Lys Thr Ala Leu Ile Leu Gly Gly Asp Arg Met Glu Asp 
        195                 200                 205             


Gln Phe Ala Ala Leu His Glu Asn Pro Asp Ile Ile Ile Ala Thr Pro 
    210                 215                 220                 


Gly Arg Leu Val His Val Ala Val Glu Met Ser Leu Lys Leu Gln Ser 
225                 230                 235                 240 


Val Glu Tyr Val Val Phe Asp Glu Ala Asp Arg Leu Phe Glu Met Gly 
                245                 250                 255     


Phe Ala Glu Gln Leu Gln Glu Ile Ile Ala Arg Leu Pro Gly Gly His 
            260                 265                 270         


Gln Thr Val Leu Phe Ser Ala Thr Leu Pro Lys Leu Leu Val Glu Phe 
        275                 280                 285             


Ala Arg Ala Gly Leu Thr Glu Pro Val Leu Ile Arg Leu Asp Val Asp 
    290                 295                 300                 


Thr Lys Leu Asn Glu Gln Leu Lys Thr Ser Phe Phe Leu Val Arg Glu 
305                 310                 315                 320 


Asp Thr Lys Ala Ala Val Leu Leu His Leu Leu His Asn Val Val Arg 
                325                 330                 335     


Pro Gln Asp Gln Thr Val Val Phe Val Ala Thr Lys His His Ala Glu 
            340                 345                 350         


Tyr Leu Thr Glu Leu Leu Thr Thr Gln Arg Val Ser Cys Ala His Ile 
        355                 360                 365             


Tyr Ser Ala Leu Asp Pro Thr Ala Arg Lys Ile Asn Leu Ala Lys Phe 
    370                 375                 380                 


Thr Leu Gly Lys Cys Ser Thr Leu Ile Val Thr Asp Leu Ala Ala Arg 
385                 390                 395                 400 


Gly Leu Asp Ile Pro Leu Leu Asp Asn Val Ile Asn Tyr Ser Phe Pro 
                405                 410                 415     


Ala Lys Gly Lys Leu Phe Leu His Arg Val Gly Arg Val Ala Arg Ala 
            420                 425                 430         


Gly Arg Ser Gly Thr Ala Tyr Ser Leu Val Ala Pro Asp Glu Ile Pro 
        435                 440                 445             


Tyr Leu Leu Asp Leu His Leu Phe Leu Gly Arg Ser Leu Thr Leu Ala 
    450                 455                 460                 


Arg Pro Leu Lys Glu Pro Ser Gly Val Ala Gly Val Asp Gly Met Leu 
465                 470                 475                 480 


Gly Arg Val Pro Gln Ser Val Val Asp Glu Glu Asp Ser Gly Leu Gln 
                485                 490                 495     


Ser Thr Leu Glu Ala Ser Leu Glu Leu Arg Gly Leu Ala Arg Val Ala 
            500                 505                 510         


Asp Asn Ala Gln Gln Gln Tyr Val Arg Ser Arg Pro Ala Pro Ser Pro 
        515                 520                 525             


Glu Ser Ile Lys Arg Ala Lys Glu Met Asp Leu Val Gly Leu Gly Leu 
    530                 535                 540                 


His Pro Leu Phe Ser Ser Arg Phe Glu Glu Glu Glu Leu Gln Arg Leu 
545                 550                 555                 560 


Arg Leu Val Asp Ser Ile Lys Asn Tyr Arg Ser Arg Ala Thr Ile Phe 
                565                 570                 575     


Glu Ile Asn Ala Ser Ser Arg Asp Leu Cys Ser Gln Val Met Arg Ala 
            580                 585                 590         


Lys Arg Gln Lys Asp Arg Lys Ala Ile Ala Arg Phe Gln Gln Gly Gln 
        595                 600                 605             


Gln Gly Arg Gln Glu Gln Gln Glu Gly Pro Val Gly Pro Ala Pro Ser 
    610                 615                 620                 


Arg Pro Ala Leu Gln Glu Lys Gln Pro Glu Lys Glu Glu Glu Glu Glu 
625                 630                 635                 640 


Ala Gly Glu Ser Val Glu Asp Ile Phe Ser Glu Val Val Gly Arg Lys 
                645                 650                 655     


Arg Gln Arg Ser Gly Pro Asn Arg Gly Ala Lys Arg Arg Arg Glu Glu 
            660                 665                 670         


Ala Arg Gln Arg Asp Gln Glu Phe Tyr Ile Pro Tyr Arg Pro Lys Asp 
        675                 680                 685             


Phe Asp Ser Glu Arg Gly Leu Ser Ile Ser Gly Glu Gly Gly Ala Phe 
    690                 695                 700                 


Glu Gln Gln Ala Ala Gly Ala Val Leu Asp Leu Met Gly Asp Glu Ala 
705                 710                 715                 720 


Gln Asn Leu Thr Arg Gly Arg Gln Gln Leu Lys Trp Asp Arg Lys Lys 
                725                 730                 735     


Lys Arg Phe Val Gly Gln Ser Gly Gln Glu Asp Lys Lys Lys Ile Lys 
            740                 745                 750         


Thr Glu Ser Gly Arg Tyr Ile Ser Ser Ser Tyr Lys Arg Asp Leu Tyr 
        755                 760                 765             


Gln Lys Trp Lys Gln Lys Gln Lys Ile Asp Asp Arg Asp Ser Asp Glu 
    770                 775                 780                 


Glu Gly Ala Ser Asp Arg Arg Gly Pro Glu Arg Arg Gly Gly Lys Arg 
785                 790                 795                 800 


Asp Arg Gly Gln Ala Gly Ala Ser Arg Pro His Ala Pro Gly Thr Pro 
                805                 810                 815     


Ala Gly Arg Val Arg Pro Glu Leu Lys Thr Lys Gln Gln Ile Leu Lys 
            820                 825                 830         


Gln Arg Arg Arg Ala Gln Lys Leu His Phe Leu Gln Arg Gly Gly Leu 
        835                 840                 845             


Lys Gln Leu Ser Ala Arg Asn Arg Arg Arg Val Gln Glu Leu Gln Gln 
    850                 855                 860                 


Gly Ala Phe Gly Arg Gly Ala Arg Ser Lys Lys Gly Lys Met Arg Lys 
865                 870                 875                 880 


Arg Met 
        


<210>  2979
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX56__Homo_sapiens__NP_001244118

<400>  2979

Met Glu Asp Ser Glu Ala Leu Gly Phe Glu His Met Gly Leu Asp Pro 
1               5                   10                  15      


Arg Leu Leu Gln Ala Val Thr Asp Leu Gly Trp Ser Arg Pro Thr Leu 
            20                  25                  30          


Ile Gln Glu Lys Ala Ile Pro Leu Ala Leu Glu Gly Lys Asp Leu Leu 
        35                  40                  45              


Ala Arg Ala Arg Thr Gly Ser Gly Lys Thr Ala Ala Tyr Ala Ile Pro 
    50                  55                  60                  


Met Leu Gln Leu Leu Leu His Arg Lys Ala Thr Gly Pro Val Val Glu 
65                  70                  75                  80  


Gln Ala Val Arg Gly Leu Val Leu Val Pro Thr Lys Glu Leu Ala Arg 
                85                  90                  95      


Gln Ala Gln Ser Met Ile Gln Gln Leu Ala Thr Tyr Cys Ala Arg Asp 
            100                 105                 110         


Val Arg Val Ala Asn Val Ser Ala Ala Glu Asp Ser Val Ser Gln Arg 
        115                 120                 125             


Ala Val Leu Met Glu Lys Pro Asp Val Val Val Gly Thr Pro Ser Arg 
    130                 135                 140                 


Ile Leu Ser His Leu Gln Gln Asp Ser Leu Lys Leu Arg Asp Ser Leu 
145                 150                 155                 160 


Glu Leu Leu Val Val Asp Glu Ala Asp Leu Leu Phe Ser Phe Gly Phe 
                165                 170                 175     


Glu Glu Glu Leu Lys Ser Leu Leu Cys His Leu Pro Arg Ile Tyr Gln 
            180                 185                 190         


Ala Phe Leu Met Ser Ala Thr Phe Asn Glu Asp Val Gln Ala Leu Lys 
        195                 200                 205             


Glu Leu Ile Leu His Asn Pro Val Thr Leu Lys Leu Gln Glu Ser Gln 
    210                 215                 220                 


Leu Pro Gly Pro Asp Gln Leu Gln Gln Phe Gln Val Val Cys Glu Thr 
225                 230                 235                 240 


Glu Glu Asp Lys Phe Leu Leu Leu Tyr Ala Leu Leu Lys Leu Ser Leu 
                245                 250                 255     


Ile Arg Gly Lys Ser Leu Leu Phe Val Asn Thr Leu Glu Arg Ser Tyr 
            260                 265                 270         


Arg Leu Arg Leu Phe Leu Glu Gln Phe Ser Ile Pro Thr Cys Val Leu 
        275                 280                 285             


Asn Gly Glu Leu Pro Leu Arg Ser Arg Ala Ser Asp Pro Glu Ala Gly 
    290                 295                 300                 


Val Ala Arg Gly Ile Asp Phe His His Val Ser Ala Val Leu Asn Phe 
305                 310                 315                 320 


Asp Leu Pro Pro Thr Pro Glu Ala Tyr Ile His Arg Ala Gly Arg Thr 
                325                 330                 335     


Ala Arg Ala Asn Asn Pro Gly Ile Val Leu Thr Phe Val Leu Pro Thr 
            340                 345                 350         


Glu Gln Phe His Leu Gly Lys Ile Glu Glu Leu Leu Ser Gly Glu Asn 
        355                 360                 365             


Arg Gly Pro Ile Leu Leu Pro Tyr Gln Phe Arg Met Glu Glu Ile Glu 
    370                 375                 380                 


Gly Phe Arg Tyr Arg Cys Arg Asp Ala Met Arg Ser Val Thr Lys Gln 
385                 390                 395                 400 


Ala Ile Arg Glu Ala Arg Leu Lys Glu Ile Lys Glu Glu Leu Leu His 
                405                 410                 415     


Ser Glu Lys Leu Lys Thr Tyr Phe Glu Asp Asn Pro Arg Asp Leu Gln 
            420                 425                 430         


Leu Leu Arg His Asp Leu Pro Leu His Pro Ala Val Val Lys Pro His 
        435                 440                 445             


Leu Gly His Val Pro Asp Tyr Leu Val Pro Pro Ala Leu Arg Gly Leu 
    450                 455                 460                 


Val Arg Pro His Lys Lys Arg Lys Lys Leu Ser Ser Ser Cys Arg Lys 
465                 470                 475                 480 


Ala Lys Arg Ala Lys Ser Gln Asn Pro Leu Arg Ser Phe Lys His Lys 
                485                 490                 495     


Gly Lys Lys Phe Arg Pro Thr Ala Lys Pro Ser 
            500                 505         


<210>  2980
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX58__Homo_sapiens__NP_055129

<400>  2980

Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys 
                245                 250                 255     


Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe 
            260                 265                 270         


Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly 
        275                 280                 285             


Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu 
    290                 295                 300                 


Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg 
305                 310                 315                 320 


Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln 
                325                 330                 335     


Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val 
            340                 345                 350         


Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu 
        355                 360                 365             


Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn 
    370                 375                 380                 


Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp 
                405                 410                 415     


Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala 
            420                 425                 430         


Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu 
        435                 440                 445             


Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu 
    450                 455                 460                 


Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg 
465                 470                 475                 480 


Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu 
                485                 490                 495     


Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp 
            500                 505                 510         


Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys 
        515                 520                 525             


Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His 
    530                 535                 540                 


Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met 
545                 550                 555                 560 


Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala 
                565                 570                 575     


Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu 
            580                 585                 590         


Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn 
        595                 600                 605             


Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu 
    610                 615                 620                 


Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val 
625                 630                 635                 640 


Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu 
                645                 650                 655     


Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly 
            660                 665                 670         


Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser 
        675                 680                 685             


Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile 
    690                 695                 700                 


Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn 
705                 710                 715                 720 


Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser 
                725                 730                 735     


Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln 
            740                 745                 750         


Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu 
        755                 760                 765             


Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln 
    770                 775                 780                 


Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val 
785                 790                 795                 800 


Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu 
                805                 810                 815     


Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr 
            820                 825                 830         


Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro 
        835                 840                 845             


Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys 
    850                 855                 860                 


Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys 
865                 870                 875                 880 


Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp 
                885                 890                 895     


Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His 
            900                 905                 910         


Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
        915                 920                 925 


<210>  2981
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX59__Homo_sapiens__NP_001026895

<400>  2981

Met Phe Val Pro Arg Ser Leu Lys Ile Lys Arg Asn Ala Asn Asp Asp 
1               5                   10                  15      


Gly Lys Ser Cys Val Ala Lys Ile Ile Lys Pro Asp Pro Glu Asp Leu 
            20                  25                  30          


Gln Leu Asp Lys Ser Arg Asp Val Pro Val Asp Ala Val Ala Thr Glu 
        35                  40                  45              


Ala Ala Thr Ile Asp Arg His Ile Ser Glu Ser Cys Pro Phe Pro Ser 
    50                  55                  60                  


Pro Gly Gly Gln Leu Ala Glu Val His Ser Val Ser Pro Glu Gln Gly 
65                  70                  75                  80  


Ala Lys Asp Ser His Pro Ser Glu Glu Pro Val Lys Ser Phe Ser Lys 
                85                  90                  95      


Thr Gln Arg Trp Ala Glu Pro Gly Glu Pro Ile Cys Val Val Cys Gly 
            100                 105                 110         


Arg Tyr Gly Glu Tyr Ile Cys Asp Lys Thr Asp Glu Asp Val Cys Ser 
        115                 120                 125             


Leu Glu Cys Lys Ala Lys His Leu Leu Gln Val Lys Glu Lys Glu Glu 
    130                 135                 140                 


Lys Ser Lys Leu Ser Asn Pro Gln Lys Ala Asp Ser Glu Pro Glu Ser 
145                 150                 155                 160 


Pro Leu Asn Ala Ser Tyr Val Tyr Lys Glu His Pro Phe Ile Leu Asn 
                165                 170                 175     


Leu Gln Glu Asp Gln Ile Glu Asn Leu Lys Gln Gln Leu Gly Ile Leu 
            180                 185                 190         


Val Gln Gly Gln Glu Val Thr Arg Pro Ile Ile Asp Phe Glu His Cys 
        195                 200                 205             


Ser Leu Pro Glu Val Leu Asn His Asn Leu Lys Lys Ser Gly Tyr Glu 
    210                 215                 220                 


Val Pro Thr Pro Ile Gln Met Gln Met Ile Pro Val Gly Leu Leu Gly 
225                 230                 235                 240 


Arg Asp Ile Leu Ala Ser Ala Asp Thr Gly Ser Gly Lys Thr Ala Ala 
                245                 250                 255     


Phe Leu Leu Pro Val Ile Met Arg Ala Leu Phe Glu Ser Lys Thr Pro 
            260                 265                 270         


Ser Ala Leu Ile Leu Thr Pro Thr Arg Glu Leu Ala Ile Gln Ile Glu 
        275                 280                 285             


Arg Gln Ala Lys Glu Leu Met Ser Gly Leu Pro Arg Met Lys Thr Val 
    290                 295                 300                 


Leu Leu Val Gly Gly Leu Pro Leu Pro Pro Gln Leu Tyr Arg Leu Gln 
305                 310                 315                 320 


Gln His Val Lys Val Ile Ile Ala Thr Pro Gly Arg Leu Leu Asp Ile 
                325                 330                 335     


Ile Lys Gln Ser Ser Val Glu Leu Cys Gly Val Lys Ile Val Val Val 
            340                 345                 350         


Asp Glu Ala Asp Thr Met Leu Lys Met Gly Phe Gln Gln Gln Val Leu 
        355                 360                 365             


Asp Ile Leu Glu Asn Ile Pro Asn Asp Cys Gln Thr Ile Leu Val Ser 
    370                 375                 380                 


Ala Thr Ile Pro Thr Ser Ile Glu Gln Leu Ala Ser Gln Leu Leu His 
385                 390                 395                 400 


Asn Pro Val Arg Ile Ile Thr Gly Glu Lys Asn Leu Pro Cys Ala Asn 
                405                 410                 415     


Val Arg Gln Ile Ile Leu Trp Val Glu Asp Pro Ala Lys Lys Lys Lys 
            420                 425                 430         


Leu Phe Glu Ile Leu Asn Asp Lys Lys Leu Phe Lys Pro Pro Val Leu 
        435                 440                 445             


Val Phe Val Asp Cys Lys Leu Gly Ala Asp Leu Leu Ser Glu Ala Val 
    450                 455                 460                 


Gln Lys Ile Thr Gly Leu Lys Ser Ile Ser Ile His Ser Glu Lys Ser 
465                 470                 475                 480 


Gln Ile Glu Arg Lys Asn Ile Leu Lys Gly Leu Leu Glu Gly Asp Tyr 
                485                 490                 495     


Glu Val Val Val Ser Thr Gly Val Leu Gly Arg Gly Leu Asp Leu Ile 
            500                 505                 510         


Ser Val Arg Leu Val Val Asn Phe Asp Met Pro Ser Ser Met Asp Glu 
        515                 520                 525             


Tyr Val His Gln Ile Gly Arg Val Gly Arg Leu Gly Gln Asn Gly Thr 
    530                 535                 540                 


Ala Ile Thr Phe Ile Asn Asn Asn Ser Lys Arg Leu Phe Trp Asp Ile 
545                 550                 555                 560 


Ala Lys Arg Val Lys Pro Thr Gly Ser Ile Leu Pro Pro Gln Leu Leu 
                565                 570                 575     


Asn Ser Pro Tyr Leu His Asp Gln Lys Arg Lys Glu Gln Gln Lys Asp 
            580                 585                 590         


Lys Gln Thr Gln Asn Asp Leu Val Thr Gly Ala Asn Leu Met Asp Ile 
        595                 600                 605             


Ile Arg Lys His Asp Lys Ser Asn Ser Gln Lys 
    610                 615                 


<210>  2982
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX5__Homo_sapiens__NP_004387

<400>  2982

Met Ser Gly Tyr Ser Ser Asp Arg Asp Arg Gly Arg Asp Arg Gly Phe 
1               5                   10                  15      


Gly Ala Pro Arg Phe Gly Gly Ser Arg Ala Gly Pro Leu Ser Gly Lys 
            20                  25                  30          


Lys Phe Gly Asn Pro Gly Glu Lys Leu Val Lys Lys Lys Trp Asn Leu 
        35                  40                  45              


Asp Glu Leu Pro Lys Phe Glu Lys Asn Phe Tyr Gln Glu His Pro Asp 
    50                  55                  60                  


Leu Ala Arg Arg Thr Ala Gln Glu Val Glu Thr Tyr Arg Arg Ser Lys 
65                  70                  75                  80  


Glu Ile Thr Val Arg Gly His Asn Cys Pro Lys Pro Val Leu Asn Phe 
                85                  90                  95      


Tyr Glu Ala Asn Phe Pro Ala Asn Val Met Asp Val Ile Ala Arg Gln 
            100                 105                 110         


Asn Phe Thr Glu Pro Thr Ala Ile Gln Ala Gln Gly Trp Pro Val Ala 
        115                 120                 125             


Leu Ser Gly Leu Asp Met Val Gly Val Ala Gln Thr Gly Ser Gly Lys 
    130                 135                 140                 


Thr Leu Ser Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro 
145                 150                 155                 160 


Phe Leu Glu Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr 
                165                 170                 175     


Arg Glu Leu Ala Gln Gln Val Gln Gln Val Ala Ala Glu Tyr Cys Arg 
            180                 185                 190         


Ala Cys Arg Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly 
        195                 200                 205             


Pro Gln Ile Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr 
    210                 215                 220                 


Pro Gly Arg Leu Ile Asp Phe Leu Glu Cys Gly Lys Thr Asn Leu Arg 
225                 230                 235                 240 


Arg Thr Thr Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met 
                245                 250                 255     


Gly Phe Glu Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp 
            260                 265                 270         


Arg Gln Thr Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln 
        275                 280                 285             


Leu Ala Glu Asp Phe Leu Lys Asp Tyr Ile His Ile Asn Ile Gly Ala 
    290                 295                 300                 


Leu Glu Leu Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys 
305                 310                 315                 320 


His Asp Val Glu Lys Asp Glu Lys Leu Ile Arg Leu Met Glu Glu Ile 
                325                 330                 335     


Met Ser Glu Lys Glu Asn Lys Thr Ile Val Phe Val Glu Thr Lys Arg 
            340                 345                 350         


Arg Cys Asp Glu Leu Thr Arg Lys Met Arg Arg Asp Gly Trp Pro Ala 
        355                 360                 365             


Met Gly Ile His Gly Asp Lys Ser Gln Gln Glu Arg Asp Trp Val Leu 
    370                 375                 380                 


Asn Glu Phe Lys His Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val 
385                 390                 395                 400 


Ala Ser Arg Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr 
                405                 410                 415     


Asp Tyr Pro Asn Ser Ser Glu Asp Tyr Ile His Arg Ile Gly Arg Thr 
            420                 425                 430         


Ala Arg Ser Thr Lys Thr Gly Thr Ala Tyr Thr Phe Phe Thr Pro Asn 
        435                 440                 445             


Asn Ile Lys Gln Val Ser Asp Leu Ile Ser Val Leu Arg Glu Ala Asn 
    450                 455                 460                 


Gln Ala Ile Asn Pro Lys Leu Leu Gln Leu Val Glu Asp Arg Gly Ser 
465                 470                 475                 480 


Gly Arg Ser Arg Gly Arg Gly Gly Met Lys Asp Asp Arg Arg Asp Arg 
                485                 490                 495     


Tyr Ser Ala Gly Lys Arg Gly Gly Phe Asn Thr Phe Arg Asp Arg Glu 
            500                 505                 510         


Asn Tyr Asp Arg Gly Tyr Ser Ser Leu Leu Lys Arg Asp Phe Gly Ala 
        515                 520                 525             


Lys Thr Gln Asn Gly Val Tyr Ser Ala Ala Asn Tyr Thr Asn Gly Ser 
    530                 535                 540                 


Phe Gly Ser Asn Phe Val Ser Ala Gly Ile Gln Thr Ser Phe Arg Thr 
545                 550                 555                 560 


Gly Asn Pro Thr Gly Thr Tyr Gln Asn Gly Tyr Asp Ser Thr Gln Gln 
                565                 570                 575     


Tyr Gly Ser Asn Val Pro Asn Met His Asn Gly Met Asn Gln Gln Ala 
            580                 585                 590         


Tyr Ala Tyr Pro Ala Thr Ala Ala Ala Pro Met Ile Gly Tyr Pro Met 
        595                 600                 605             


Pro Thr Gly Tyr Ser Gln 
    610                 


<210>  2983
<211>  1712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX60__Homo_sapiens__NP_060101

<400>  2983

Met Glu Arg Asn Val Leu Thr Thr Phe Ser Gln Glu Met Ser Gln Leu 
1               5                   10                  15      


Ile Leu Asn Glu Met Pro Lys Ala Glu Tyr Ser Ser Leu Phe Asn Asp 
            20                  25                  30          


Phe Val Glu Ser Glu Phe Phe Leu Ile Asp Gly Asp Ser Leu Leu Ile 
        35                  40                  45              


Thr Cys Ile Cys Glu Ile Ser Phe Lys Pro Gly Gln Asn Leu His Phe 
    50                  55                  60                  


Phe Tyr Leu Val Glu Arg Tyr Leu Val Asp Leu Ile Ser Lys Gly Gly 
65                  70                  75                  80  


Gln Phe Thr Ile Val Phe Phe Lys Asp Ala Glu Tyr Ala Tyr Phe Asn 
                85                  90                  95      


Phe Pro Glu Leu Leu Ser Leu Arg Thr Ala Leu Ile Leu His Leu Gln 
            100                 105                 110         


Lys Asn Thr Thr Ile Asp Val Arg Thr Thr Phe Ser Arg Cys Leu Ser 
        115                 120                 125             


Lys Glu Trp Gly Ser Phe Leu Glu Glu Ser Tyr Pro Tyr Phe Leu Ile 
    130                 135                 140                 


Val Ala Asp Glu Gly Leu Asn Asp Leu Gln Thr Gln Leu Phe Asn Phe 
145                 150                 155                 160 


Leu Ile Ile His Ser Trp Ala Arg Lys Val Asn Val Val Leu Ser Ser 
                165                 170                 175     


Gly Gln Glu Ser Asp Val Leu Cys Leu Tyr Ala Tyr Leu Leu Pro Ser 
            180                 185                 190         


Met Tyr Arg His Gln Ile Phe Ser Trp Lys Asn Lys Gln Asn Ile Lys 
        195                 200                 205             


Asp Ala Tyr Thr Thr Leu Leu Asn Gln Leu Glu Arg Phe Lys Leu Ser 
    210                 215                 220                 


Ala Leu Ala Pro Leu Phe Gly Ser Leu Lys Trp Asn Asn Ile Thr Glu 
225                 230                 235                 240 


Glu Ala His Lys Thr Val Ser Leu Leu Thr Gln Val Trp Pro Glu Gly 
                245                 250                 255     


Ser Asp Ile Arg Arg Val Phe Cys Val Thr Ser Cys Ser Leu Ser Leu 
            260                 265                 270         


Arg Met Tyr His Arg Phe Leu Gly Asn Arg Glu Pro Ser Ser Gly Gln 
        275                 280                 285             


Glu Thr Glu Ile Gln Gln Val Asn Ser Asn Cys Leu Thr Leu Gln Glu 
    290                 295                 300                 


Met Glu Asp Leu Cys Lys Leu His Cys Leu Thr Val Val Phe Leu Leu 
305                 310                 315                 320 


His Leu Pro Leu Ser Gln Arg Ala Cys Ala Arg Val Ile Thr Ser His 
                325                 330                 335     


Trp Ala Glu Asp Met Lys Pro Leu Leu Gln Met Lys Lys Trp Cys Glu 
            340                 345                 350         


Tyr Phe Ile Leu Arg Asn Ile His Thr Phe Glu Phe Trp Asn Leu Asn 
        355                 360                 365             


Leu Ile His Leu Ser Asp Leu Asn Asp Glu Leu Leu Leu Lys Asn Ile 
    370                 375                 380                 


Ala Phe Tyr Tyr Glu Asn Glu Asn Val Lys Gly Leu His Leu Asn Leu 
385                 390                 395                 400 


Gly Asp Thr Ile Met Lys Asp Tyr Glu Tyr Leu Trp Asn Thr Val Ser 
                405                 410                 415     


Lys Leu Val Arg Asp Phe Glu Val Gly Gln Pro Phe Pro Leu Arg Thr 
            420                 425                 430         


Thr Lys Val Cys Phe Leu Glu Lys Lys Pro Ser Pro Ile Lys Asp Ser 
        435                 440                 445             


Ser Asn Glu Met Val Pro Asn Leu Gly Phe Ile Pro Thr Ser Ser Phe 
    450                 455                 460                 


Val Val Asp Lys Phe Ala Gly Asp Ile Leu Lys Asp Leu Pro Phe Leu 
465                 470                 475                 480 


Lys Ser Asp Asp Pro Ile Val Thr Ser Leu Val Lys Gln Lys Glu Phe 
                485                 490                 495     


Asp Glu Leu Val His Trp His Ser His Lys Pro Leu Ser Asp Asp Tyr 
            500                 505                 510         


Asp Arg Ser Arg Cys Gln Phe Asp Glu Lys Ser Arg Asp Pro Arg Val 
        515                 520                 525             


Leu Arg Ser Val Gln Lys Tyr His Val Phe Gln Arg Phe Tyr Gly Asn 
    530                 535                 540                 


Ser Leu Glu Thr Val Ser Ser Lys Ile Ile Val Thr Gln Thr Ile Lys 
545                 550                 555                 560 


Ser Lys Lys Asp Phe Ser Gly Pro Lys Ser Lys Lys Ala His Glu Thr 
                565                 570                 575     


Lys Ala Glu Ile Ile Ala Arg Glu Asn Lys Lys Arg Leu Phe Ala Arg 
            580                 585                 590         


Glu Glu Gln Lys Glu Glu Gln Lys Trp Asn Ala Leu Ser Phe Ser Ile 
        595                 600                 605             


Glu Glu Gln Leu Lys Glu Asn Leu His Ser Gly Ile Lys Ser Leu Glu 
    610                 615                 620                 


Asp Phe Leu Lys Ser Cys Lys Ser Ser Cys Val Lys Leu Gln Val Glu 
625                 630                 635                 640 


Met Val Gly Leu Thr Ala Cys Leu Lys Ala Trp Lys Glu His Cys Arg 
                645                 650                 655     


Ser Glu Glu Gly Lys Thr Thr Lys Asp Leu Ser Ile Ala Val Gln Val 
            660                 665                 670         


Met Lys Arg Ile His Ser Leu Met Glu Lys Tyr Ser Glu Leu Leu Gln 
        675                 680                 685             


Glu Asp Asp Arg Gln Leu Ile Ala Arg Cys Leu Lys Tyr Leu Gly Phe 
    690                 695                 700                 


Asp Glu Leu Ala Ser Ser Leu His Pro Ala Gln Asp Ala Glu Asn Asp 
705                 710                 715                 720 


Val Lys Val Lys Lys Arg Asn Lys Tyr Ser Val Gly Ile Gly Pro Ala 
                725                 730                 735     


Arg Phe Gln Leu Gln Tyr Met Gly His Tyr Leu Ile Arg Asp Glu Arg 
            740                 745                 750         


Lys Asp Pro Asp Pro Arg Val Gln Asp Phe Ile Pro Asp Thr Trp Gln 
        755                 760                 765             


Arg Glu Leu Leu Asp Val Val Asp Lys Asn Glu Ser Ala Val Ile Val 
    770                 775                 780                 


Ala Pro Thr Ser Ser Gly Lys Thr Tyr Ala Ser Tyr Tyr Cys Met Glu 
785                 790                 795                 800 


Lys Val Leu Lys Glu Ser Asp Asp Gly Val Val Val Tyr Val Ala Pro 
                805                 810                 815     


Thr Lys Ala Leu Val Asn Gln Val Ala Ala Thr Val Gln Asn Arg Phe 
            820                 825                 830         


Thr Lys Asn Leu Pro Ser Gly Glu Val Leu Cys Gly Val Phe Thr Arg 
        835                 840                 845             


Glu Tyr Arg His Asp Ala Leu Asn Cys Gln Val Leu Ile Thr Val Pro 
    850                 855                 860                 


Ala Cys Phe Glu Ile Leu Leu Leu Ala Pro His Arg Gln Asn Trp Val 
865                 870                 875                 880 


Lys Lys Ile Arg Tyr Val Ile Phe Asp Glu Val His Cys Leu Gly Gly 
                885                 890                 895     


Glu Ile Gly Ala Glu Ile Trp Glu His Leu Leu Val Met Ile Arg Cys 
            900                 905                 910         


Pro Phe Leu Ala Leu Ser Ala Thr Ile Ser Asn Pro Glu His Leu Thr 
        915                 920                 925             


Glu Trp Leu Gln Ser Val Lys Trp Tyr Trp Lys Gln Glu Asp Lys Ile 
    930                 935                 940                 


Ile Glu Asn Asn Thr Ala Ser Lys Arg His Val Gly Arg Gln Ala Gly 
945                 950                 955                 960 


Phe Pro Lys Asp Tyr Leu Gln Val Lys Gln Ser Tyr Lys Val Arg Leu 
                965                 970                 975     


Val Leu Tyr Gly Glu Arg Tyr Asn Asp Leu Glu Lys His Val Cys Ser 
            980                 985                 990         


Ile Lys His Gly Asp Ile His Phe  Asp His Phe His Pro  Cys Ala Ala 
        995                 1000                 1005             


Leu Thr  Thr Asp His Ile Glu  Arg Tyr Gly Phe Pro  Pro Asp Leu 
    1010                 1015                 1020             


Thr Leu  Ser Pro Arg Glu Ser  Ile Gln Leu Tyr Asp  Ala Met Phe 
    1025                 1030                 1035             


Gln Ile  Trp Lys Ser Trp Pro  Arg Ala Gln Glu Leu  Cys Pro Glu 
    1040                 1045                 1050             


Asn Phe  Ile His Phe Asn Asn  Lys Leu Val Ile Lys  Lys Met Asp 
    1055                 1060                 1065             


Ala Arg  Lys Tyr Glu Glu Ser  Leu Lys Ala Glu Leu  Thr Ser Trp 
    1070                 1075                 1080             


Ile Lys  Asn Gly Asn Val Glu  Gln Ala Arg Met Val  Leu Gln Asn 
    1085                 1090                 1095             


Leu Ser  Pro Glu Ala Asp Leu  Ser Pro Glu Asn Met  Ile Thr Met 
    1100                 1105                 1110             


Phe Pro  Leu Leu Val Glu Lys  Leu Arg Lys Met Glu  Lys Leu Pro 
    1115                 1120                 1125             


Ala Leu  Phe Phe Leu Phe Lys  Leu Gly Ala Val Glu  Asn Ala Ala 
    1130                 1135                 1140             


Glu Ser  Val Ser Thr Phe Leu  Lys Lys Lys Gln Glu  Thr Lys Arg 
    1145                 1150                 1155             


Pro Pro  Lys Ala Asp Lys Glu  Ala His Val Met Ala  Asn Lys Leu 
    1160                 1165                 1170             


Arg Lys  Val Lys Lys Ser Ile  Glu Lys Gln Lys Ile  Ile Asp Glu 
    1175                 1180                 1185             


Lys Ser  Gln Lys Lys Thr Arg  Asn Val Asp Gln Ser  Leu Ile His 
    1190                 1195                 1200             


Glu Ala  Glu His Asp Asn Leu  Val Lys Cys Leu Glu  Lys Asn Leu 
    1205                 1210                 1215             


Glu Ile  Pro Gln Asp Cys Thr  Tyr Ala Asp Gln Lys  Ala Val Asp 
    1220                 1225                 1230             


Thr Glu  Thr Leu Gln Lys Val  Phe Gly Arg Val Lys  Phe Glu Arg 
    1235                 1240                 1245             


Lys Gly  Glu Glu Leu Lys Ala  Leu Ala Glu Arg Gly  Ile Gly Tyr 
    1250                 1255                 1260             


His His  Ser Ala Met Ser Phe  Lys Glu Lys Gln Leu  Val Glu Ile 
    1265                 1270                 1275             


Leu Phe  Arg Lys Gly Tyr Leu  Arg Val Val Thr Ala  Thr Gly Thr 
    1280                 1285                 1290             


Leu Ala  Leu Gly Val Asn Met  Pro Cys Lys Ser Val  Val Phe Ala 
    1295                 1300                 1305             


Gln Asn  Ser Val Tyr Leu Asp  Ala Leu Asn Tyr Arg  Gln Met Ser 
    1310                 1315                 1320             


Gly Arg  Ala Gly Arg Arg Gly  Gln Asp Leu Met Gly  Asp Val Tyr 
    1325                 1330                 1335             


Phe Phe  Asp Ile Pro Phe Pro  Lys Ile Gly Lys Leu  Ile Lys Ser 
    1340                 1345                 1350             


Asn Val  Pro Glu Leu Arg Gly  His Phe Pro Leu Ser  Ile Thr Leu 
    1355                 1360                 1365             


Val Leu  Arg Leu Met Leu Leu  Ala Ser Lys Gly Asp  Asp Pro Glu 
    1370                 1375                 1380             


Asp Ala  Lys Ala Lys Val Leu  Ser Val Leu Lys His  Ser Leu Leu 
    1385                 1390                 1395             


Ser Phe  Lys Gln Pro Arg Val  Met Asp Met Leu Lys  Leu Tyr Phe 
    1400                 1405                 1410             


Leu Phe  Ser Leu Gln Phe Leu  Val Lys Glu Gly Tyr  Leu Asp Gln 
    1415                 1420                 1425             


Glu Gly  Asn Pro Met Gly Phe  Ala Gly Leu Val Ser  His Leu His 
    1430                 1435                 1440             


Tyr His  Glu Pro Ser Asn Leu  Val Phe Val Ser Phe  Leu Val Asn 
    1445                 1450                 1455             


Gly Leu  Phe His Asp Leu Cys  Gln Pro Thr Arg Lys  Gly Ser Lys 
    1460                 1465                 1470             


His Phe  Ser Gln Asp Val Met  Glu Lys Leu Val Leu  Val Leu Ala 
    1475                 1480                 1485             


His Leu  Phe Gly Arg Arg Tyr  Phe Pro Pro Lys Phe  Gln Asp Ala 
    1490                 1495                 1500             


His Phe  Glu Phe Tyr Gln Ser  Lys Val Phe Leu Asp  Asp Leu Pro 
    1505                 1510                 1515             


Glu Asp  Phe Ser Asp Ala Leu  Asp Glu Tyr Asn Met  Lys Ile Met 
    1520                 1525                 1530             


Glu Asp  Phe Thr Thr Phe Leu  Arg Ile Val Ser Lys  Leu Ala Asp 
    1535                 1540                 1545             


Met Asn  Gln Glu Tyr Gln Leu  Pro Leu Ser Lys Ile  Lys Phe Thr 
    1550                 1555                 1560             


Gly Lys  Glu Cys Glu Asp Ser  Gln Leu Val Ser His  Leu Met Ser 
    1565                 1570                 1575             


Cys Lys  Glu Gly Arg Val Ala  Ile Ser Pro Phe Val  Cys Leu Ser 
    1580                 1585                 1590             


Gly Asn  Phe Asp Asp Asp Leu  Leu Arg Leu Glu Thr  Pro Asn His 
    1595                 1600                 1605             


Val Thr  Leu Gly Thr Ile Gly  Val Asn Arg Ser Gln  Ala Pro Val 
    1610                 1615                 1620             


Leu Leu  Ser Gln Lys Phe Asp  Asn Arg Gly Arg Lys  Met Ser Leu 
    1625                 1630                 1635             


Asn Ala  Tyr Ala Leu Asp Phe  Tyr Lys His Gly Ser  Leu Ile Gly 
    1640                 1645                 1650             


Leu Val  Gln Asp Asn Arg Met  Asn Glu Gly Asp Ala  Tyr Tyr Leu 
    1655                 1660                 1665             


Leu Lys  Asp Phe Ala Leu Thr  Ile Lys Ser Ile Ser  Val Ser Leu 
    1670                 1675                 1680             


Arg Glu  Leu Cys Glu Asn Glu  Asp Asp Asn Val Val  Leu Ala Phe 
    1685                 1690                 1695             


Glu Gln  Leu Ser Thr Thr Phe  Trp Glu Lys Leu Asn  Lys Val 
    1700                 1705                 1710         


<210>  2984
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DDX6__Homo_sapiens__NP_004388

<400>  2984

Met Ser Thr Ala Arg Thr Glu Asn Pro Val Ile Met Gly Leu Ser Ser 
1               5                   10                  15      


Gln Asn Gly Gln Leu Arg Gly Pro Val Lys Pro Thr Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Gly Thr Gln Thr Gln Gln Gln Met Asn Gln Leu Lys Asn Thr 
        35                  40                  45              


Asn Thr Ile Asn Asn Gly Thr Gln Gln Gln Ala Gln Ser Met Thr Thr 
    50                  55                  60                  


Thr Ile Lys Pro Gly Asp Asp Trp Lys Lys Thr Leu Lys Leu Pro Pro 
65                  70                  75                  80  


Lys Asp Leu Arg Ile Lys Thr Ser Asp Val Thr Ser Thr Lys Gly Asn 
                85                  90                  95      


Glu Phe Glu Asp Tyr Cys Leu Lys Arg Glu Leu Leu Met Gly Ile Phe 
            100                 105                 110         


Glu Met Gly Trp Glu Lys Pro Ser Pro Ile Gln Glu Glu Ser Ile Pro 
        115                 120                 125             


Ile Ala Leu Ser Gly Arg Asp Ile Leu Ala Arg Ala Lys Asn Gly Thr 
    130                 135                 140                 


Gly Lys Ser Gly Ala Tyr Leu Ile Pro Leu Leu Glu Arg Leu Asp Leu 
145                 150                 155                 160 


Lys Lys Asp Asn Ile Gln Ala Met Val Ile Val Pro Thr Arg Glu Leu 
                165                 170                 175     


Ala Leu Gln Val Ser Gln Ile Cys Ile Gln Val Ser Lys His Met Gly 
            180                 185                 190         


Gly Ala Lys Val Met Ala Thr Thr Gly Gly Thr Asn Leu Arg Asp Asp 
        195                 200                 205             


Ile Met Arg Leu Asp Asp Thr Val His Val Val Ile Ala Thr Pro Gly 
    210                 215                 220                 


Arg Ile Leu Asp Leu Ile Lys Lys Gly Val Ala Lys Val Asp His Val 
225                 230                 235                 240 


Gln Met Ile Val Leu Asp Glu Ala Asp Lys Leu Leu Ser Gln Asp Phe 
                245                 250                 255     


Val Gln Ile Met Glu Asp Ile Ile Leu Thr Leu Pro Lys Asn Arg Gln 
            260                 265                 270         


Ile Leu Leu Tyr Ser Ala Thr Phe Pro Leu Ser Val Gln Lys Phe Met 
        275                 280                 285             


Asn Ser His Leu Gln Lys Pro Tyr Glu Ile Asn Leu Met Glu Glu Leu 
    290                 295                 300                 


Thr Leu Lys Gly Val Thr Gln Tyr Tyr Ala Tyr Val Thr Glu Arg Gln 
305                 310                 315                 320 


Lys Val His Cys Leu Asn Thr Leu Phe Ser Arg Leu Gln Ile Asn Gln 
                325                 330                 335     


Ser Ile Ile Phe Cys Asn Ser Ser Gln Arg Val Glu Leu Leu Ala Lys 
            340                 345                 350         


Lys Ile Ser Gln Leu Gly Tyr Ser Cys Phe Tyr Ile His Ala Lys Met 
        355                 360                 365             


Arg Gln Glu His Arg Asn Arg Val Phe His Asp Phe Arg Asn Gly Leu 
    370                 375                 380                 


Cys Arg Asn Leu Val Cys Thr Asp Leu Phe Thr Arg Gly Ile Asp Ile 
385                 390                 395                 400 


Gln Ala Val Asn Val Val Ile Asn Phe Asp Phe Pro Lys Leu Ala Glu 
                405                 410                 415     


Thr Tyr Leu His Arg Ile Gly Arg Ser Gly Arg Phe Gly His Leu Gly 
            420                 425                 430         


Leu Ala Ile Asn Leu Ile Thr Tyr Asp Asp Arg Phe Asn Leu Lys Ser 
        435                 440                 445             


Ile Glu Glu Gln Leu Gly Thr Glu Ile Lys Pro Ile Pro Ser Asn Ile 
    450                 455                 460                 


Asp Lys Ser Leu Tyr Val Ala Glu Tyr His Ser Glu Pro Val Glu Asp 
465                 470                 475                 480 


Glu Lys Pro 
            


<210>  2985
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEAF1__Homo_sapiens__NP_001280563

<400>  2985

Met Glu Asp Ser Asp Ser Ala Ala Lys Gln Leu Gly Leu Ala Glu Ala 
1               5                   10                  15      


Ala Ala Val Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gly Gly Glu Ala Glu Glu Pro Val Leu Ser Arg Asp Glu Asp Ser 
        35                  40                  45              


Glu Glu Asp Ala Asp Ser Glu Ala Glu Arg Glu Thr Pro Arg Val Thr 
    50                  55                  60                  


Ala Val Ala Val Met Ala Ala Glu Pro Gly His Met Asp Met Gly Ala 
65                  70                  75                  80  


Glu Ala Leu Pro Gly Pro Asp Glu Ala Ala Ala Ala Ala Ala Phe Ala 
                85                  90                  95      


Glu Val Thr Thr Val Thr Val Ala Asn Val Gly Ala Ala Ala Asp Asn 
            100                 105                 110         


Val Phe Thr Thr Ser Val Ala Asn Ala Ala Ser Ile Ser Gly His Val 
        115                 120                 125             


Leu Ser Gly Arg Thr Ala Leu Gln Ile Gly Asp Ser Leu Asn Thr Glu 
    130                 135                 140                 


Lys Ala Thr Leu Ile Val Val His Thr Asp Gly Ser Ile Val Glu Thr 
145                 150                 155                 160 


Thr Gly Leu Lys Gly Pro Ala Ala Pro Leu Thr Pro Gly Pro Gln Ser 
                165                 170                 175     


Pro Pro Thr Pro Leu Ala Pro Gly Gln Glu Lys Gly Gly Thr Lys Tyr 
            180                 185                 190         


Asn Trp Asp Pro Ser Val Tyr Asp Ser Glu Leu Pro Val Arg Cys Arg 
        195                 200                 205             


Asn Ile Ser Gly Thr Leu Tyr Lys Asn Arg Leu Gly Ser Gly Trp Asp 
    210                 215                 220                 


Leu Lys Pro Ser Arg Cys Leu Leu His Leu Cys Cys Leu Leu Arg Arg 
225                 230                 235                 240 


His Asp Leu Ile Thr Val Thr Pro Ser Gly Gln Ile Thr Thr Ser Gly 
                245                 250                 255     


Ala Leu Thr Phe Asp Arg Ala Ser Thr Val Glu Ala Thr Ala Val Ile 
            260                 265                 270         


Ser Glu Ser Pro Ala Gln Gly Asp Val Phe Ala Gly Ala Thr Val Gln 
        275                 280                 285             


Glu Ala Ser Val Gln Pro Pro Cys Arg Ala Ser His Pro Glu Pro His 
    290                 295                 300                 


Tyr Pro Gly Tyr Gln Asp Ser Cys Gln Ile Ala Pro Phe Pro Glu Ala 
305                 310                 315                 320 


Ala Leu Pro Thr Ser His Pro Lys Ile Val Leu Thr Ser Leu Pro Ala 
                325                 330                 335     


Leu Ala Val Pro Pro Pro Thr Pro Thr Lys Ala Ala Pro Pro Ala Leu 
            340                 345                 350         


Val Asn Gly Leu Glu Leu Ser Glu Pro Arg Ser Trp Leu Tyr Leu Glu 
        355                 360                 365             


Glu Met Val Asn Ser Leu Leu Asn Thr Ala Gln Gln Leu Lys Thr Leu 
    370                 375                 380                 


Phe Glu Gln Ala Lys His Ala Ser Thr Tyr Arg Glu Ala Ala Thr Asn 
385                 390                 395                 400 


Gln Ala Lys Ile His Ala Asp Ala Glu Arg Lys Glu Val Ile His Pro 
                405                 410                 415     


Pro Arg Leu Pro Lys Val Leu Gly Leu Gln Gln Ser Cys Val Asn Cys 
            420                 425                 430         


Gly Arg Glu Ala Met Ser Glu Cys Thr Gly Cys His Lys Val Asn Tyr 
        435                 440                 445             


Cys Ser Thr Phe Cys Gln Arg Lys Asp Trp Lys Asp His Gln His Ile 
    450                 455                 460                 


Cys Gly Gln Ser Ala Ala Val Thr Val Gln Ala Asp Glu Val His Val 
465                 470                 475                 480 


Ala Glu Ser Val Met Glu Lys Val Thr Val 
                485                 490 


<210>  2986
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEC1__Homo_sapiens__XP_011517055

<400>  2986

Met Thr Met Asn Val Leu Glu Ala Gly Lys Trp Lys Ser Ile Val Pro 
1               5                   10                  15      


Ala Pro Gly Glu Gly Leu Leu Ala Val Leu His Met Met Val Phe Thr 
            20                  25                  30          


Asp Ala Leu His Arg Glu Arg Ser Val Lys Trp Gln Ala Gly Val Cys 
        35                  40                  45              


Tyr Asn Gly Gly Lys Asp Phe Ala Val Ser Leu Ala Arg Pro Lys Ala 
    50                  55                  60                  


Ala Glu Gly Ile Ala Asp 
65                  70  


<210>  2987
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DECR1__Homo_sapiens__NP_001350

<400>  2987

Met Lys Leu Pro Ala Arg Val Phe Phe Thr Leu Gly Ser Arg Leu Pro 
1               5                   10                  15      


Cys Gly Leu Ala Pro Arg Arg Phe Phe Ser Tyr Gly Thr Lys Ile Leu 
            20                  25                  30          


Tyr Gln Asn Thr Glu Ala Leu Gln Ser Lys Phe Phe Ser Pro Leu Gln 
        35                  40                  45              


Lys Ala Met Leu Pro Pro Asn Ser Phe Gln Gly Lys Val Ala Phe Ile 
    50                  55                  60                  


Thr Gly Gly Gly Thr Gly Leu Gly Lys Gly Met Thr Thr Leu Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Lys Met Asp Val Leu 
                85                  90                  95      


Lys Ala Thr Ala Glu Gln Ile Ser Ser Gln Thr Gly Asn Lys Val His 
            100                 105                 110         


Ala Ile Gln Cys Asp Val Arg Asp Pro Asp Met Val Gln Asn Thr Val 
        115                 120                 125             


Ser Glu Leu Ile Lys Val Ala Gly His Pro Asn Ile Val Ile Asn Asn 
    130                 135                 140                 


Ala Ala Gly Asn Phe Ile Ser Pro Thr Glu Arg Leu Ser Pro Asn Ala 
145                 150                 155                 160 


Trp Lys Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Phe Val Thr 
                165                 170                 175     


Leu Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Ala Ala Phe 
            180                 185                 190         


Leu Ser Ile Thr Thr Ile Tyr Ala Glu Thr Gly Ser Gly Phe Val Val 
        195                 200                 205             


Pro Ser Ala Ser Ala Lys Ala Gly Val Glu Ala Met Ser Lys Ser Leu 
    210                 215                 220                 


Ala Ala Glu Trp Gly Lys Tyr Gly Met Arg Phe Asn Val Ile Gln Pro 
225                 230                 235                 240 


Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly 
                245                 250                 255     


Thr Phe Glu Lys Glu Met Ile Gly Arg Ile Pro Cys Gly Arg Leu Gly 
            260                 265                 270         


Thr Val Glu Glu Leu Ala Asn Leu Ala Ala Phe Leu Cys Ser Asp Tyr 
        275                 280                 285             


Ala Ser Trp Ile Asn Gly Ala Val Ile Lys Phe Asp Gly Gly Glu Glu 
    290                 295                 300                 


Val Leu Ile Ser Gly Glu Phe Asn Asp Leu Arg Lys Val Thr Lys Glu 
305                 310                 315                 320 


Gln Trp Asp Thr Ile Glu Glu Leu Ile Arg Lys Thr Lys Gly Ser 
                325                 330                 335 


<210>  2988
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEDD__Homo_sapiens__NP_001034801

<400>  2988

Met Ala Gly Leu Lys Arg Arg Ala Ser Gln Val Trp Pro Glu Glu His 
1               5                   10                  15      


Gly Glu Gln Glu His Gly Leu Tyr Ser Leu His Arg Met Phe Asp Ile 
            20                  25                  30          


Val Gly Thr His Leu Thr His Arg Asp Val Arg Val Leu Ser Phe Leu 
        35                  40                  45              


Phe Val Asp Val Ile Asp Asp His Glu Arg Gly Leu Ile Arg Asn Gly 
    50                  55                  60                  


Arg Asp Phe Leu Leu Ala Leu Glu Arg Gln Gly Arg Cys Asp Glu Ser 
65                  70                  75                  80  


Asn Phe Arg Gln Val Leu Gln Leu Leu Arg Ile Ile Thr Arg His Asp 
                85                  90                  95      


Leu Leu Pro Tyr Val Thr Leu Lys Arg Arg Arg Ala Val Cys Pro Asp 
            100                 105                 110         


Leu Val Asp Lys Tyr Leu Glu Glu Thr Ser Ile Arg Tyr Val Thr Pro 
        115                 120                 125             


Arg Ala Leu Ser Asp Pro Glu Pro Arg Pro Pro Gln Pro Ser Lys Thr 
    130                 135                 140                 


Val Pro Pro His Tyr Pro Val Val Cys Cys Pro Thr Ser Gly Pro Gln 
145                 150                 155                 160 


Met Cys Ser Lys Arg Pro Ala Arg Gly Arg Ala Thr Leu Gly Ser Gln 
                165                 170                 175     


Arg Lys Arg Arg Lys Ser Val Thr Pro Asp Pro Lys Glu Lys Gln Thr 
            180                 185                 190         


Cys Asp Ile Arg Leu Arg Val Arg Ala Glu Tyr Cys Gln His Glu Thr 
        195                 200                 205             


Ala Leu Gln Gly Asn Val Phe Ser Asn Lys Gln Asp Pro Leu Glu Arg 
    210                 215                 220                 


Gln Phe Glu Arg Phe Asn Gln Ala Asn Thr Ile Leu Lys Ser Arg Asp 
225                 230                 235                 240 


Leu Gly Ser Ile Ile Cys Asp Ile Lys Phe Ser Glu Leu Thr Tyr Leu 
                245                 250                 255     


Asp Ala Phe Trp Arg Asp Tyr Ile Asn Gly Ser Leu Leu Glu Ala Leu 
            260                 265                 270         


Lys Gly Val Phe Ile Thr Asp Ser Leu Lys Gln Ala Val Gly His Glu 
        275                 280                 285             


Ala Ile Lys Leu Leu Val Asn Val Asp Glu Glu Asp Tyr Glu Leu Gly 
    290                 295                 300                 


Arg Gln Lys Leu Leu Arg Asn Leu Met Leu Gln Ala Leu Pro 
305                 310                 315             


<210>  2989
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEF6__Homo_sapiens__NP_071330

<400>  2989

Met Ala Leu Arg Lys Glu Leu Leu Lys Ser Ile Trp Tyr Ala Phe Thr 
1               5                   10                  15      


Ala Leu Asp Val Glu Lys Ser Gly Lys Val Ser Lys Ser Gln Leu Lys 
            20                  25                  30          


Val Leu Ser His Asn Leu Tyr Thr Val Leu His Ile Pro His Asp Pro 
        35                  40                  45              


Val Ala Leu Glu Glu His Phe Arg Asp Asp Asp Asp Gly Pro Val Ser 
    50                  55                  60                  


Ser Gln Gly Tyr Met Pro Tyr Leu Asn Lys Tyr Ile Leu Asp Lys Val 
65                  70                  75                  80  


Glu Glu Gly Ala Phe Val Lys Glu His Phe Asp Glu Leu Cys Trp Thr 
                85                  90                  95      


Leu Thr Ala Lys Lys Asn Tyr Arg Ala Asp Ser Asn Gly Asn Ser Met 
            100                 105                 110         


Leu Ser Asn Gln Asp Ala Phe Arg Leu Trp Cys Leu Phe Asn Phe Leu 
        115                 120                 125             


Ser Glu Asp Lys Tyr Pro Leu Ile Met Val Pro Asp Glu Val Glu Tyr 
    130                 135                 140                 


Leu Leu Lys Lys Val Leu Ser Ser Met Ser Leu Glu Val Ser Leu Gly 
145                 150                 155                 160 


Glu Leu Glu Glu Leu Leu Ala Gln Glu Ala Gln Val Ala Gln Thr Thr 
                165                 170                 175     


Gly Gly Leu Ser Val Trp Gln Phe Leu Glu Leu Phe Asn Ser Gly Arg 
            180                 185                 190         


Cys Leu Arg Gly Val Gly Arg Asp Thr Leu Ser Met Ala Ile His Glu 
        195                 200                 205             


Val Tyr Gln Glu Leu Ile Gln Asp Val Leu Lys Gln Gly Tyr Leu Trp 
    210                 215                 220                 


Lys Arg Gly His Leu Arg Arg Asn Trp Ala Glu Arg Trp Phe Gln Leu 
225                 230                 235                 240 


Gln Pro Ser Cys Leu Cys Tyr Phe Gly Ser Glu Glu Cys Lys Glu Lys 
                245                 250                 255     


Arg Gly Ile Ile Pro Leu Asp Ala His Cys Cys Val Glu Val Leu Pro 
            260                 265                 270         


Asp Arg Asp Gly Lys Arg Cys Met Phe Cys Val Lys Thr Ala Asn Arg 
        275                 280                 285             


Thr Tyr Glu Met Ser Ala Ser Asp Thr Arg Gln Arg Gln Glu Trp Thr 
    290                 295                 300                 


Ala Ala Ile Gln Met Ala Ile Arg Leu Gln Ala Glu Gly Lys Thr Ser 
305                 310                 315                 320 


Leu His Lys Asp Leu Lys Gln Lys Arg Arg Glu Gln Arg Glu Gln Arg 
                325                 330                 335     


Glu Arg Arg Arg Ala Ala Lys Glu Glu Glu Leu Leu Arg Leu Gln Gln 
            340                 345                 350         


Leu Gln Glu Glu Lys Glu Arg Lys Leu Gln Glu Leu Glu Leu Leu Gln 
        355                 360                 365             


Glu Ala Gln Arg Gln Ala Glu Arg Leu Leu Gln Glu Glu Glu Glu Arg 
    370                 375                 380                 


Arg Arg Ser Gln His Arg Glu Leu Gln Gln Ala Leu Glu Gly Gln Leu 
385                 390                 395                 400 


Arg Glu Ala Glu Gln Ala Arg Ala Ser Met Gln Ala Glu Met Glu Leu 
                405                 410                 415     


Lys Glu Glu Glu Ala Ala Arg Gln Arg Gln Arg Ile Lys Glu Leu Glu 
            420                 425                 430         


Glu Met Gln Gln Arg Leu Gln Glu Ala Leu Gln Leu Glu Val Lys Ala 
        435                 440                 445             


Arg Arg Asp Glu Glu Ser Val Arg Ile Ala Gln Thr Arg Leu Leu Glu 
    450                 455                 460                 


Glu Glu Glu Glu Lys Leu Lys Gln Leu Met Gln Leu Lys Glu Glu Gln 
465                 470                 475                 480 


Glu Arg Tyr Ile Glu Arg Ala Gln Gln Glu Lys Glu Glu Leu Gln Gln 
                485                 490                 495     


Glu Met Ala Gln Gln Ser Arg Ser Leu Gln Gln Ala Gln Gln Gln Leu 
            500                 505                 510         


Glu Glu Val Arg Gln Asn Arg Gln Arg Ala Asp Glu Asp Val Glu Ala 
        515                 520                 525             


Ala Gln Arg Lys Leu Arg Gln Ala Ser Thr Asn Val Lys His Trp Asn 
    530                 535                 540                 


Val Gln Met Asn Arg Leu Met His Pro Ile Glu Pro Gly Asp Lys Arg 
545                 550                 555                 560 


Pro Val Thr Ser Ser Ser Phe Ser Gly Phe Gln Pro Pro Leu Leu Ala 
                565                 570                 575     


His Arg Asp Ser Ser Leu Lys Arg Leu Thr Arg Trp Gly Ser Gln Gly 
            580                 585                 590         


Asn Arg Thr Pro Ser Pro Asn Ser Asn Glu Gln Gln Lys Ser Leu Asn 
        595                 600                 605             


Gly Gly Asp Glu Ala Pro Ala Pro Ala Ser Thr Pro Gln Glu Asp Lys 
    610                 615                 620                 


Leu Asp Pro Ala Pro Glu Asn 
625                 630     


<210>  2990
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFA1B__Homo_sapiens__NP_001035965

<400>  2990

Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210>  2991
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFA3__Homo_sapiens__NP_005208

<400>  2991

Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Asp Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210>  2992
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFA4__Homo_sapiens__NP_001916

<400>  2992

Met Arg Ile Ile Ala Leu Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Val Arg Ala Gly Pro Leu Gln Ala Arg Gly Asp Glu Ala Pro Gly Gln 
            20                  25                  30          


Glu Gln Arg Gly Pro Glu Asp Gln Asp Ile Ser Ile Ser Phe Ala Trp 
        35                  40                  45              


Asp Lys Ser Ser Ala Leu Gln Val Ser Gly Ser Thr Arg Gly Met Val 
    50                  55                  60                  


Cys Ser Cys Arg Leu Val Phe Cys Arg Arg Thr Glu Leu Arg Val Gly 
65                  70                  75                  80  


Asn Cys Leu Ile Gly Gly Val Ser Phe Thr Tyr Cys Cys Thr Arg Val 
                85                  90                  95      


Asp 
    


<210>  2993
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFA5__Homo_sapiens__NP_066290

<400>  2993

Met Arg Thr Ile Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Ser Leu Gln Glu Arg Ala Asp Glu Ala Thr Thr Gln 
            20                  25                  30          


Lys Gln Ser Gly Glu Asp Asn Gln Asp Leu Ala Ile Ser Phe Ala Gly 
        35                  40                  45              


Asn Gly Leu Ser Ala Leu Arg Thr Ser Gly Ser Gln Ala Arg Ala Thr 
    50                  55                  60                  


Cys Tyr Cys Arg Thr Gly Arg Cys Ala Thr Arg Glu Ser Leu Ser Gly 
65                  70                  75                  80  


Val Cys Glu Ile Ser Gly Arg Leu Tyr Arg Leu Cys Cys Arg 
                85                  90                  


<210>  2994
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFA6__Homo_sapiens__NP_001917

<400>  2994

Met Arg Thr Leu Thr Ile Leu Thr Ala Val Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Lys Ala Glu Pro Leu Gln Ala Glu Asp Asp Pro Leu Gln Ala Lys 
            20                  25                  30          


Ala Tyr Glu Ala Asp Ala Gln Glu Gln Arg Gly Ala Asn Asp Gln Asp 
        35                  40                  45              


Phe Ala Val Ser Phe Ala Glu Asp Ala Ser Ser Ser Leu Arg Ala Leu 
    50                  55                  60                  


Gly Ser Thr Arg Ala Phe Thr Cys His Cys Arg Arg Ser Cys Tyr Ser 
65                  70                  75                  80  


Thr Glu Tyr Ser Tyr Gly Thr Cys Thr Val Met Gly Ile Asn His Arg 
                85                  90                  95      


Phe Cys Cys Leu 
            100 


<210>  2995
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB103B__Homo_sapiens__NP_061131

<400>  2995

Met Arg Ile His Tyr Leu Leu Phe Ala Leu Leu Phe Leu Phe Leu Val 
1               5                   10                  15      


Pro Val Pro Gly His Gly Gly Ile Ile Asn Thr Leu Gln Lys Tyr Tyr 
            20                  25                  30          


Cys Arg Val Arg Gly Gly Arg Cys Ala Val Leu Ser Cys Leu Pro Lys 
        35                  40                  45              


Glu Glu Gln Ile Gly Lys Cys Ser Thr Arg Gly Arg Lys Cys Cys Arg 
    50                  55                  60                  


Arg Lys Lys 
65          


<210>  2996
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB104B__Homo_sapiens__NP_001035792

<400>  2996

Met Gln Arg Leu Val Leu Leu Leu Ala Ile Ser Leu Leu Leu Tyr Gln 
1               5                   10                  15      


Asp Leu Pro Val Arg Ser Glu Phe Glu Leu Asp Arg Ile Cys Gly Tyr 
            20                  25                  30          


Gly Thr Ala Arg Cys Arg Lys Lys Cys Arg Ser Gln Glu Tyr Arg Ile 
        35                  40                  45              


Gly Arg Cys Pro Asn Thr Tyr Ala Cys Cys Leu Arg Lys Trp Asp Glu 
    50                  55                  60                  


Ser Leu Leu Asn Arg Thr Lys Pro 
65                  70          


<210>  2997
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB105A__Homo_sapiens__NP_689463

<400>  2997

Met Ala Leu Ile Arg Lys Thr Phe Tyr Phe Leu Phe Ala Met Phe Phe 
1               5                   10                  15      


Ile Leu Val Gln Leu Pro Ser Gly Cys Gln Ala Gly Leu Asp Phe Ser 
            20                  25                  30          


Gln Pro Phe Pro Ser Gly Glu Phe Ala Val Cys Glu Ser Cys Lys Leu 
        35                  40                  45              


Gly Arg Gly Lys Cys Arg Lys Glu Cys Leu Glu Asn Glu Lys Pro Asp 
    50                  55                  60                  


Gly Asn Cys Arg Leu Asn Phe Leu Cys Cys Arg Gln Arg Ile 
65                  70                  75              


<210>  2998
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB106A__Homo_sapiens__NP_689464

<400>  2998

Met Arg Thr Phe Leu Phe Leu Phe Ala Val Leu Phe Phe Leu Thr Pro 
1               5                   10                  15      


Ala Lys Asn Ala Phe Phe Asp Glu Lys Cys Asn Lys Leu Lys Gly Thr 
            20                  25                  30          


Cys Lys Asn Asn Cys Gly Lys Asn Glu Glu Leu Ile Ala Leu Cys Gln 
        35                  40                  45              


Lys Ser Leu Lys Cys Cys Arg Thr Ile Gln Pro Cys Gly Ser Ile Ile 
    50                  55                  60                  


Asp 
65  


<210>  2999
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB108B__Homo_sapiens__NP_001002035

<400>  2999

Met Arg Ile Ala Val Leu Leu Phe Ala Ile Phe Phe Phe Met Ser Gln 
1               5                   10                  15      


Val Leu Pro Ala Arg Gly Lys Phe Lys Glu Ile Cys Glu Arg Pro Asn 
            20                  25                  30          


Gly Ser Cys Arg Asp Phe Cys Leu Glu Thr Glu Ile His Val Gly Arg 
        35                  40                  45              


Cys Leu Asn Ser Gln Pro Cys Cys Leu Pro Leu Gly His Gln Pro Arg 
    50                  55                  60                  


Ile Glu Ser Thr Thr Pro Lys Lys Asp 
65                  70              


<210>  3000
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB112__Homo_sapiens__NP_001032587

<400>  3000

Met Lys Leu Leu Thr Thr Ile Cys Arg Leu Lys Leu Glu Lys Met Tyr 
1               5                   10                  15      


Ser Lys Thr Asn Thr Ser Ser Thr Ile Phe Glu Lys Ala Arg His Gly 
            20                  25                  30          


Thr Glu Lys Ile Ser Thr Ala Arg Ser Glu Gly His His Ile Thr Phe 
        35                  40                  45              


Ser Arg Trp Lys Ser Cys Thr Ala Ile Gly Gly Arg Cys Lys Asn Gln 
    50                  55                  60                  


Cys Asp Asp Ser Glu Phe Arg Ile Ser Tyr Cys Ala Arg Pro Thr Thr 
65                  70                  75                  80  


His Cys Cys Val Thr Glu Cys Asp Pro Thr Asp Pro Asn Asn Trp Ile 
                85                  90                  95      


Pro Lys Asp Ser Val Gly Thr Gln Glu Trp Tyr Pro Lys Asp Ser Arg 
            100                 105                 110         


His 
    


<210>  3001
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB125__Homo_sapiens__NP_697020

<400>  3001

Met Asn Ile Leu Met Leu Thr Phe Ile Ile Cys Gly Leu Leu Thr Arg 
1               5                   10                  15      


Val Thr Lys Gly Ser Phe Glu Pro Gln Lys Cys Trp Lys Asn Asn Val 
            20                  25                  30          


Gly His Cys Arg Arg Arg Cys Leu Asp Thr Glu Arg Tyr Ile Leu Leu 
        35                  40                  45              


Cys Arg Asn Lys Leu Ser Cys Cys Ile Ser Ile Ile Ser His Glu Tyr 
    50                  55                  60                  


Thr Arg Arg Pro Ala Phe Pro Val Ile His Leu Glu Asp Ile Thr Leu 
65                  70                  75                  80  


Asp Tyr Ser Asp Val Asp Ser Phe Thr Gly Ser Pro Val Ser Met Leu 
                85                  90                  95      


Asn Asp Leu Ile Thr Phe Asp Thr Thr Lys Phe Gly Glu Thr Met Thr 
            100                 105                 110         


Pro Glu Thr Asn Thr Pro Glu Thr Thr Met Pro Pro Ser Glu Ala Thr 
        115                 120                 125             


Thr Pro Glu Thr Thr Met Pro Pro Ser Glu Thr Ala Thr Ser Glu Thr 
    130                 135                 140                 


Met Pro Pro Pro Ser Gln Thr Ala Leu Thr His Asn 
145                 150                 155     


<210>  3002
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB126__Homo_sapiens__NP_112193

<400>  3002

Met Lys Ser Leu Leu Phe Thr Leu Ala Val Phe Met Leu Leu Ala Gln 
1               5                   10                  15      


Leu Val Ser Gly Asn Trp Tyr Val Lys Lys Cys Leu Asn Asp Val Gly 
            20                  25                  30          


Ile Cys Lys Lys Lys Cys Lys Pro Glu Glu Met His Val Lys Asn Gly 
        35                  40                  45              


Trp Ala Met Cys Gly Lys Gln Arg Asp Cys Cys Val Pro Ala Asp Arg 
    50                  55                  60                  


Arg Ala Asn Tyr Pro Val Phe Cys Val Gln Thr Lys Thr Thr Arg Ile 
65                  70                  75                  80  


Ser Thr Val Thr Ala Thr Thr Ala Thr Thr Thr Leu Met Met Thr Thr 
                85                  90                  95      


Ala Ser Met Ser Ser Met Ala Pro Thr Pro Val Ser Pro Thr Gly 
            100                 105                 110     


<210>  3003
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB1__Homo_sapiens__NP_005209

<400>  3003

Met Arg Thr Ser Tyr Leu Leu Leu Phe Thr Leu Cys Leu Leu Leu Ser 
1               5                   10                  15      


Glu Met Ala Ser Gly Gly Asn Phe Leu Thr Gly Leu Gly His Arg Ser 
            20                  25                  30          


Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
        35                  40                  45              


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
    50                  55                  60                  


Lys Cys Cys Lys 
65              


<210>  3004
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEFB4A__Homo_sapiens__NP_004933

<400>  3004

Met Arg Val Leu Tyr Leu Leu Phe Ser Phe Leu Phe Ile Phe Leu Met 
1               5                   10                  15      


Pro Leu Pro Gly Val Phe Gly Gly Ile Gly Asp Pro Val Thr Cys Leu 
            20                  25                  30          


Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys Pro Arg Arg Tyr Lys 
        35                  40                  45              


Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys Cys Cys Lys Lys Pro 
    50                  55                  60                  


<210>  3005
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEGS1__Homo_sapiens__NP_003667

<400>  3005

Met Gly Ser Arg Val Ser Arg Glu Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Ala Asp Arg Arg Arg Glu Ile Leu Ala Lys Tyr Pro Glu 
            20                  25                  30          


Ile Lys Ser Leu Met Lys Pro Asp Pro Asn Leu Ile Trp Ile Ile Ile 
        35                  40                  45              


Met Met Val Leu Thr Gln Leu Gly Ala Phe Tyr Ile Val Lys Asp Leu 
    50                  55                  60                  


Asp Trp Lys Trp Val Ile Phe Gly Ala Tyr Ala Phe Gly Ser Cys Ile 
65                  70                  75                  80  


Asn His Ser Met Thr Leu Ala Ile His Glu Ile Ala His Asn Ala Ala 
                85                  90                  95      


Phe Gly Asn Cys Lys Ala Met Trp Asn Arg Trp Phe Gly Met Phe Ala 
            100                 105                 110         


Asn Leu Pro Ile Gly Ile Pro Tyr Ser Ile Ser Phe Lys Arg Tyr His 
        115                 120                 125             


Met Asp His His Arg Tyr Leu Gly Ala Asp Gly Val Asp Val Asp Ile 
    130                 135                 140                 


Pro Thr Asp Phe Glu Gly Trp Phe Phe Cys Thr Ala Phe Arg Lys Phe 
145                 150                 155                 160 


Ile Trp Val Ile Leu Gln Pro Leu Phe Tyr Ala Phe Arg Pro Leu Phe 
                165                 170                 175     


Ile Asn Pro Lys Pro Ile Thr Tyr Leu Glu Val Ile Asn Thr Val Ala 
            180                 185                 190         


Gln Val Thr Phe Asp Ile Leu Ile Tyr Tyr Phe Leu Gly Ile Lys Ser 
        195                 200                 205             


Leu Val Tyr Met Leu Ala Ala Ser Leu Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Ile Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Leu Leu Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Asn Glu His His Asp Phe Pro Asn Ile Pro Gly Lys Ser 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Ala Glu Tyr Tyr Asp Asn Leu Pro 
        275                 280                 285             


His Tyr Asn Ser Trp Ile Lys Val Leu Tyr Asp Phe Val Met Asp Asp 
    290                 295                 300                 


Thr Ile Ser Pro Tyr Ser Arg Met Lys Arg His Gln Lys Gly Glu Met 
305                 310                 315                 320 


Val Leu Glu 
            


<210>  3006
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEGS2__Homo_sapiens__NP_996801

<400>  3006

Met Gly Asn Ser Ala Ser Arg Ser Asp Phe Glu Trp Val Tyr Thr Asp 
1               5                   10                  15      


Gln Pro His Thr Gln Arg Arg Lys Glu Ile Leu Ala Lys Tyr Pro Ala 
            20                  25                  30          


Ile Lys Ala Leu Met Arg Pro Asp Pro Arg Leu Lys Trp Ala Val Leu 
        35                  40                  45              


Val Leu Val Leu Val Gln Met Leu Ala Cys Trp Leu Val Arg Gly Leu 
    50                  55                  60                  


Ala Trp Arg Trp Leu Leu Phe Trp Ala Tyr Ala Phe Gly Gly Cys Val 
65                  70                  75                  80  


Asn His Ser Leu Thr Leu Ala Ile His Asp Ile Ser His Asn Ala Ala 
                85                  90                  95      


Phe Gly Thr Gly Arg Ala Ala Arg Asn Arg Trp Leu Ala Val Phe Ala 
            100                 105                 110         


Asn Leu Pro Val Gly Val Pro Tyr Ala Ala Ser Phe Lys Lys Tyr His 
        115                 120                 125             


Val Asp His His Arg Tyr Leu Gly Gly Asp Gly Leu Asp Val Asp Val 
    130                 135                 140                 


Pro Thr Arg Leu Glu Gly Trp Phe Phe Cys Thr Pro Ala Arg Lys Leu 
145                 150                 155                 160 


Leu Trp Leu Val Leu Gln Pro Phe Phe Tyr Ser Leu Arg Pro Leu Cys 
                165                 170                 175     


Val His Pro Lys Ala Val Thr Arg Met Glu Val Leu Asn Thr Leu Val 
            180                 185                 190         


Gln Leu Ala Ala Asp Leu Ala Ile Phe Ala Leu Trp Gly Leu Lys Pro 
        195                 200                 205             


Val Val Tyr Leu Leu Ala Ser Ser Phe Leu Gly Leu Gly Leu His Pro 
    210                 215                 220                 


Ile Ser Gly His Phe Val Ala Glu His Tyr Met Phe Leu Lys Gly His 
225                 230                 235                 240 


Glu Thr Tyr Ser Tyr Tyr Gly Pro Leu Asn Trp Ile Thr Phe Asn Val 
                245                 250                 255     


Gly Tyr His Val Glu His His Asp Phe Pro Ser Ile Pro Gly Tyr Asn 
            260                 265                 270         


Leu Pro Leu Val Arg Lys Ile Ala Pro Glu Tyr Tyr Asp His Leu Pro 
        275                 280                 285             


Gln His His Ser Trp Val Lys Val Leu Trp Asp Phe Val Phe Glu Asp 
    290                 295                 300                 


Ser Leu Gly Pro Tyr Ala Arg Val Lys Arg Val Tyr Arg Leu Ala Lys 
305                 310                 315                 320 


Asp Gly Leu 
            


<210>  3007
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEK__Homo_sapiens__NP_001128181

<400>  3007

Met Ser Ala Ser Ala Pro Ala Ala Glu Gly Glu Gly Thr Pro Thr Gln 
1               5                   10                  15      


Pro Ala Ser Glu Lys Glu Pro Glu Met Pro Gly Pro Arg Glu Glu Ser 
            20                  25                  30          


Glu Glu Glu Glu Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Lys 
        35                  40                  45              


Gly Lys Gly Gln Lys Leu Cys Glu Ile Glu Arg Ile His Phe Phe Leu 
    50                  55                  60                  


Ser Lys Lys Lys Thr Asp Glu Leu Arg Asn Leu His Lys Leu Leu Tyr 
65                  70                  75                  80  


Asn Arg Pro Gly Thr Val Ser Ser Leu Lys Lys Asn Val Gly Gln Phe 
                85                  90                  95      


Ser Gly Phe Pro Phe Glu Lys Gly Ser Val Gln Tyr Lys Lys Lys Glu 
            100                 105                 110         


Glu Met Leu Lys Lys Phe Arg Asn Ala Met Leu Lys Ser Ile Cys Glu 
        115                 120                 125             


Val Leu Asp Leu Glu Arg Ser Gly Val Asn Ser Glu Leu Val Lys Arg 
    130                 135                 140                 


Ile Leu Asn Phe Leu Met His Pro Lys Pro Ser Gly Lys Pro Leu Pro 
145                 150                 155                 160 


Lys Ser Lys Lys Thr Cys Ser Lys Gly Ser Lys Lys Glu Arg Asn Ser 
                165                 170                 175     


Ser Gly Met Ala Arg Lys Ala Lys Arg Thr Lys Cys Pro Glu Ile Leu 
            180                 185                 190         


Ser Asp Glu Ser Ser Ser Asp Glu Asp Glu Lys Lys Asn Lys Glu Glu 
        195                 200                 205             


Ser Ser Asp Asp Glu Asp Lys Glu Ser Glu Glu Glu Pro Pro Lys Lys 
    210                 215                 220                 


Thr Ala Lys Arg Glu Lys Pro Lys Gln Lys Ala Thr Ser Lys Ser Lys 
225                 230                 235                 240 


Lys Ser Val Lys Ser Ala Asn Val Lys Lys Ala Asp Ser Ser Thr Thr 
                245                 250                 255     


Lys Lys Asn Gln Asn Ser Ser Lys Lys Glu Ser Glu Ser Glu Asp Ser 
            260                 265                 270         


Ser Asp Asp Glu Pro Leu Ile Lys Lys Leu Lys Lys Pro Pro Thr Asp 
        275                 280                 285             


Glu Glu Leu Lys Glu Thr Ile Lys Lys Leu Leu Ala Ser Ala Asn Leu 
    290                 295                 300                 


Glu Glu Val Thr Met Lys Gln Ile Cys Lys Lys Val Tyr Glu Asn Tyr 
305                 310                 315                 320 


Pro Thr Tyr Asp Leu Thr Glu Arg Lys Asp Phe Ile Lys Thr Thr Val 
                325                 330                 335     


Lys Glu Leu Ile Ser 
            340     


<210>  3008
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENND1A__Homo_sapiens__NP_065997

<400>  3008

Met Gly Ser Arg Ile Lys Gln Asn Pro Glu Thr Thr Phe Glu Val Tyr 
1               5                   10                  15      


Val Glu Val Ala Tyr Pro Arg Thr Gly Gly Thr Leu Ser Asp Pro Glu 
            20                  25                  30          


Val Gln Arg Gln Phe Pro Glu Asp Tyr Ser Asp Gln Glu Val Leu Gln 
        35                  40                  45              


Thr Leu Thr Lys Phe Cys Phe Pro Phe Tyr Val Asp Ser Leu Thr Val 
    50                  55                  60                  


Ser Gln Val Gly Gln Asn Phe Thr Phe Val Leu Thr Asp Ile Asp Ser 
65                  70                  75                  80  


Lys Gln Arg Phe Gly Phe Cys Arg Leu Ser Ser Gly Ala Lys Ser Cys 
                85                  90                  95      


Phe Cys Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Phe Tyr Lys Leu 
            100                 105                 110         


Leu Asn Ile Leu Ala Asp Tyr Thr Thr Lys Arg Gln Glu Asn Gln Trp 
        115                 120                 125             


Asn Glu Leu Leu Glu Thr Leu His Lys Leu Pro Ile Pro Asp Pro Gly 
    130                 135                 140                 


Val Ser Val His Leu Ser Val His Ser Tyr Phe Thr Val Pro Asp Thr 
145                 150                 155                 160 


Arg Glu Leu Pro Ser Ile Pro Glu Asn Arg Asn Leu Thr Glu Tyr Phe 
                165                 170                 175     


Val Ala Val Asp Val Asn Asn Met Leu His Leu Tyr Ala Ser Met Leu 
            180                 185                 190         


Tyr Glu Arg Arg Ile Leu Ile Ile Cys Ser Lys Leu Ser Thr Leu Thr 
        195                 200                 205             


Ala Cys Ile His Gly Ser Ala Ala Met Leu Tyr Pro Met Tyr Trp Gln 
    210                 215                 220                 


His Val Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr Cys Cys 
225                 230                 235                 240 


Ala Pro Met Pro Tyr Leu Ile Gly Ile His Leu Ser Leu Met Glu Lys 
                245                 250                 255     


Val Arg Asn Met Ala Leu Asp Asp Val Val Ile Leu Asn Val Asp Thr 
            260                 265                 270         


Asn Thr Leu Glu Thr Pro Phe Asp Asp Leu Gln Ser Leu Pro Asn Asp 
        275                 280                 285             


Val Ile Ser Ser Leu Lys Asn Arg Leu Lys Lys Val Ser Thr Thr Thr 
    290                 295                 300                 


Gly Asp Gly Val Ala Arg Ala Phe Leu Lys Ala Gln Ala Ala Phe Phe 
305                 310                 315                 320 


Gly Ser Tyr Arg Asn Ala Leu Lys Ile Glu Pro Glu Glu Pro Ile Thr 
                325                 330                 335     


Phe Cys Glu Glu Ala Phe Val Ser His Tyr Arg Ser Gly Ala Met Arg 
            340                 345                 350         


Gln Phe Leu Gln Asn Ala Thr Gln Leu Gln Leu Phe Lys Gln Phe Ile 
        355                 360                 365             


Asp Gly Arg Leu Asp Leu Leu Asn Ser Gly Glu Gly Phe Ser Asp Val 
    370                 375                 380                 


Phe Glu Glu Glu Ile Asn Met Gly Glu Tyr Ala Gly Ser Asp Lys Leu 
385                 390                 395                 400 


Tyr His Gln Trp Leu Ser Thr Val Arg Lys Gly Ser Gly Ala Ile Leu 
                405                 410                 415     


Asn Thr Val Lys Thr Lys Ala Asn Pro Ala Met Lys Thr Val Tyr Lys 
            420                 425                 430         


Phe Ala Lys Asp His Ala Lys Met Gly Ile Lys Glu Val Lys Asn Arg 
        435                 440                 445             


Leu Lys Gln Lys Asp Ile Ala Glu Asn Gly Cys Ala Pro Thr Pro Glu 
    450                 455                 460                 


Glu Gln Leu Pro Lys Thr Ala Pro Ser Pro Leu Val Glu Ala Lys Asp 
465                 470                 475                 480 


Pro Lys Leu Arg Glu Asp Arg Arg Pro Ile Thr Val His Phe Gly Gln 
                485                 490                 495     


Val Arg Pro Pro Arg Pro His Val Val Lys Arg Pro Lys Ser Asn Ile 
            500                 505                 510         


Ala Val Glu Gly Arg Arg Thr Ser Val Pro Ser Pro Glu Gln Pro Gln 
        515                 520                 525             


Pro Tyr Arg Thr Leu Arg Glu Ser Asp Ser Ala Glu Gly Asp Glu Ala 
    530                 535                 540                 


Glu Ser Pro Glu Gln Gln Val Arg Lys Ser Thr Gly Pro Val Pro Ala 
545                 550                 555                 560 


Pro Pro Asp Arg Ala Ala Ser Ile Asp Leu Leu Glu Asp Val Phe Ser 
                565                 570                 575     


Asn Leu Asp Met Glu Ala Ala Leu Gln Pro Leu Gly Gln Ala Lys Ser 
            580                 585                 590         


Leu Glu Asp Leu Arg Ala Pro Lys Asp Leu Arg Glu Gln Pro Gly Thr 
        595                 600                 605             


Phe Asp Tyr Gln Arg Leu Asp Leu Gly Gly Ser Glu Arg Ser Arg Gly 
    610                 615                 620                 


Val Thr Val Ala Leu Lys Leu Thr His Pro Tyr Asn Lys Leu Trp Ser 
625                 630                 635                 640 


Leu Gly Gln Asp Asp Met Ala Ile Pro Ser Lys Pro Pro Ala Ala Ser 
                645                 650                 655     


Pro Glu Lys Pro Ser Ala Leu Leu Gly Asn Ser Leu Ala Leu Pro Arg 
            660                 665                 670         


Arg Pro Gln Asn Arg Asp Ser Ile Leu Asn Pro Ser Asp Lys Glu Glu 
        675                 680                 685             


Val Pro Thr Pro Thr Leu Gly Ser Ile Thr Ile Pro Arg Pro Gln Gly 
    690                 695                 700                 


Arg Lys Thr Pro Glu Leu Gly Ile Val Pro Pro Pro Pro Ile Pro Arg 
705                 710                 715                 720 


Pro Ala Lys Leu Gln Ala Ala Gly Ala Ala Leu Gly Asp Val Ser Glu 
                725                 730                 735     


Arg Leu Gln Thr Asp Arg Asp Arg Arg Ala Ala Leu Ser Pro Gly Leu 
            740                 745                 750         


Leu Pro Gly Val Val Pro Gln Gly Pro Thr Glu Leu Leu Gln Pro Leu 
        755                 760                 765             


Ser Pro Gly Pro Gly Ala Ala Gly Thr Ser Ser Asp Ala Leu Leu Ala 
    770                 775                 780                 


Leu Leu Asp Pro Leu Ser Thr Ala Trp Ser Gly Ser Thr Leu Pro Ser 
785                 790                 795                 800 


Arg Pro Ala Thr Pro Asn Val Ala Thr Pro Phe Thr Pro Gln Phe Ser 
                805                 810                 815     


Phe Pro Pro Ala Gly Thr Pro Thr Pro Phe Pro Gln Pro Pro Leu Asn 
            820                 825                 830         


Pro Phe Val Pro Ser Met Pro Ala Ala Pro Pro Thr Leu Pro Leu Val 
        835                 840                 845             


Ser Thr Pro Ala Gly Pro Phe Gly Ala Pro Pro Ala Ser Leu Gly Pro 
    850                 855                 860                 


Ala Phe Ala Ser Gly Leu Leu Leu Ser Ser Ala Gly Phe Cys Ala Pro 
865                 870                 875                 880 


His Arg Ser Gln Pro Asn Leu Ser Ala Leu Ser Met Pro Asn Leu Phe 
                885                 890                 895     


Gly Gln Met Pro Met Gly Thr His Thr Ser Pro Leu Gln Pro Leu Gly 
            900                 905                 910         


Pro Pro Ala Val Ala Pro Ser Arg Ile Arg Thr Leu Pro Leu Ala Arg 
        915                 920                 925             


Ser Ser Ala Arg Ala Ala Glu Thr Lys Gln Gly Leu Ala Leu Arg Pro 
    930                 935                 940                 


Gly Asp Pro Pro Leu Leu Pro Pro Arg Pro Pro Gln Gly Leu Glu Pro 
945                 950                 955                 960 


Thr Leu Gln Pro Ser Ala Pro Gln Gln Ala Arg Asp Pro Phe Glu Asp 
                965                 970                 975     


Leu Leu Gln Lys Thr Lys Gln Asp Val Ser Pro Ser Pro Ala Leu Ala 
            980                 985                 990         


Pro Ala Pro Asp Ser Val Glu Gln  Leu Arg Lys Gln Trp  Glu Thr Phe 
        995                 1000                 1005             


Glu 
    


<210>  3009
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENND1B__Homo_sapiens__NP_001287787

<400>  3009

Met Ala Ala Ala Pro Arg Glu Glu Lys Arg Trp Pro Gln Pro Val Phe 
1               5                   10                  15      


Ser Asn Pro Val Val Leu Trp Lys Phe Pro Glu Asp Phe Gly Asp Gln 
            20                  25                  30          


Glu Ile Leu Gln Ser Val Pro Lys Phe Cys Phe Pro Phe Asp Val Glu 
        35                  40                  45              


Arg Val Ser Gln Asn Gln Val Gly Gln His Phe Thr Phe Val Leu Thr 
    50                  55                  60                  


Asp Ile Glu Ser Lys Gln Arg Phe Gly Phe Cys Arg Leu Thr Ser Gly 
65                  70                  75                  80  


Gly Thr Ile Cys Leu Cys Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val 
                85                  90                  95      


Tyr Tyr Lys Leu Leu Asn Thr Leu Ala Asp Tyr Leu Ala Lys Glu Leu 
            100                 105                 110         


Glu Asn Asp Leu Asn Glu Thr Leu Arg Ser Leu Tyr Asn His Pro Val 
        115                 120                 125             


Pro Lys Ala Asn Thr Pro Val Asn Leu Ser Val His Ser Tyr Phe Ile 
    130                 135                 140                 


Ala Pro Asp Val Thr Gly Leu Pro Thr Ile Pro Glu Ser Arg Asn Leu 
145                 150                 155                 160 


Thr Glu Tyr Phe Val Ala Val Asp Val Asn Asn Met Leu Gln Leu Tyr 
                165                 170                 175     


Ala Ser Met Leu His Glu Arg Arg Ile Val Ile Ile Ser Ser Lys Leu 
            180                 185                 190         


Ser Thr Leu Thr Ala Cys Ile His Gly Ser Ala Ala Leu Leu Tyr Pro 
        195                 200                 205             


Met Tyr Trp Gln His Ile Tyr Ile Pro Val Leu Pro Pro His Leu Leu 
    210                 215                 220                 


Asp Tyr Cys Cys Ala Pro Met Pro Tyr Leu Ile Gly Ile His Ser Ser 
225                 230                 235                 240 


Leu Ile Glu Arg Val Lys Asn Lys Ser Leu Glu Asp Val Val Met Leu 
                245                 250                 255     


Asn Val Asp Thr Asn Thr Leu Glu Ser Pro Phe Ser Asp Leu Asn Asn 
            260                 265                 270         


Leu Pro Ser Asp Val Val Ser Ala Leu Lys Asn Lys Leu Lys Lys Gln 
        275                 280                 285             


Ser Thr Ala Thr Gly Asp Gly Val Ala Arg Ala Phe Leu Arg Ala Gln 
    290                 295                 300                 


Ala Ala Leu Phe Gly Ser Tyr Arg Asp Ala Leu Arg Tyr Lys Pro Gly 
305                 310                 315                 320 


Glu Pro Ile Thr Phe Cys Glu Glu Ser Phe Val Lys His Arg Ser Ser 
                325                 330                 335     


Val Met Lys Gln Phe Leu Glu Thr Ala Ile Asn Leu Gln Leu Phe Lys 
            340                 345                 350         


Gln Phe Ile Asp Gly Arg Leu Ala Lys Leu Asn Ala Gly Arg Gly Phe 
        355                 360                 365             


Ser Asp Val Phe Glu Glu Glu Ile Thr Ser Gly Gly Phe Cys Gly Gly 
    370                 375                 380                 


Lys Asp Lys Leu Gln Tyr Asp Tyr Pro Phe Ser Gln 
385                 390                 395     


<210>  3010
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENND2A__Homo_sapiens__NP_056504

<400>  3010

Met Asp Met Phe Ser Leu Asp Met Ile Ile Ser Asp Pro Ala Ala Glu 
1               5                   10                  15      


Ala Ser Arg Ala Gly Lys Lys Gln Leu Arg Gly Val Gln Asn Pro Cys 
            20                  25                  30          


Pro Ser Ala Arg Ala Arg Pro Arg His Lys Ser Leu Asn Ile Lys Asp 
        35                  40                  45              


Lys Ile Ser Glu Trp Glu Gly Lys Lys Glu Val Pro Thr Pro Ala Pro 
    50                  55                  60                  


Ser Arg Arg Ala Asp Gly Gln Glu Asp Tyr Leu Pro Ser Ser Thr Val 
65                  70                  75                  80  


Glu Arg Arg Ser Ser Asp Gly Val Arg Thr Gln Val Thr Glu Ala Lys 
                85                  90                  95      


Asn Gly Met Arg Pro Gly Thr Glu Ser Thr Glu Lys Glu Arg Asn Lys 
            100                 105                 110         


Gly Ala Val Asn Val Gly Gly Gln Asp Pro Glu Pro Gly Gln Asp Leu 
        115                 120                 125             


Ser Gln Pro Glu Arg Glu Val Asp Pro Ser Trp Gly Arg Gly Arg Glu 
    130                 135                 140                 


Pro Arg Leu Gly Lys Leu Arg Phe Gln Asn Asp Pro Leu Ser Val Leu 
145                 150                 155                 160 


Lys Gln Val Lys Lys Leu Glu Gln Ala Leu Lys Asp Gly Ser Ala Gly 
                165                 170                 175     


Leu Asp Pro Gln Leu Pro Gly Thr Cys Tyr Ser Pro His Cys Pro Pro 
            180                 185                 190         


Asp Lys Ala Glu Ala Gly Ser Thr Leu Pro Glu Asn Leu Gly Gly Gly 
        195                 200                 205             


Ser Gly Ser Glu Val Ser Gln Arg Val His Pro Ser Asp Leu Glu Gly 
    210                 215                 220                 


Arg Glu Pro Thr Pro Glu Leu Val Glu Asp Arg Lys Gly Ser Cys Arg 
225                 230                 235                 240 


Arg Pro Trp Asp Arg Ser Leu Glu Asn Val Tyr Arg Gly Ser Glu Gly 
                245                 250                 255     


Ser Pro Thr Lys Pro Phe Ile Asn Pro Leu Pro Lys Pro Arg Arg Thr 
            260                 265                 270         


Phe Lys His Ala Gly Glu Gly Asp Lys Asp Gly Lys Pro Gly Ile Gly 
        275                 280                 285             


Phe Arg Lys Glu Lys Arg Asn Leu Pro Pro Leu Pro Ser Leu Pro Pro 
    290                 295                 300                 


Pro Pro Leu Pro Ser Ser Pro Pro Pro Ser Ser Val Asn Arg Arg Leu 
305                 310                 315                 320 


Trp Thr Gly Arg Gln Lys Ser Ser Ala Asp His Arg Lys Ser Tyr Glu 
                325                 330                 335     


Phe Glu Asp Leu Leu Gln Ser Ser Ser Glu Ser Ser Arg Val Asp Trp 
            340                 345                 350         


Tyr Ala Gln Thr Lys Leu Gly Leu Thr Arg Thr Leu Ser Glu Glu Asn 
        355                 360                 365             


Val Tyr Glu Asp Ile Leu Asp Pro Pro Met Lys Glu Asn Pro Tyr Glu 
    370                 375                 380                 


Asp Ile Glu Leu His Gly Arg Cys Leu Gly Lys Lys Cys Val Leu Asn 
385                 390                 395                 400 


Phe Pro Ala Ser Pro Thr Ser Ser Ile Pro Asp Thr Leu Thr Lys Gln 
                405                 410                 415     


Ser Leu Ser Lys Pro Ala Phe Phe Arg Gln Asn Ser Glu Arg Arg Asn 
            420                 425                 430         


Phe Lys Leu Leu Asp Thr Arg Lys Leu Ser Arg Asp Gly Thr Gly Ser 
        435                 440                 445             


Pro Ser Lys Ile Ser Pro Pro Ser Thr Pro Ser Ser Pro Asp Asp Ile 
    450                 455                 460                 


Phe Phe Asn Leu Gly Asp Pro Gln Asn Gly Arg Lys Lys Arg Lys Ile 
465                 470                 475                 480 


Pro Lys Leu Val Leu Arg Ile Asn Ala Ile Tyr Glu Val Arg Arg Gly 
                485                 490                 495     


Lys Lys Arg Val Lys Arg Leu Ser Gln Ser Met Glu Ser Asn Ser Gly 
            500                 505                 510         


Lys Val Thr Asp Glu Asn Ser Glu Ser Asp Ser Asp Thr Glu Glu Lys 
        515                 520                 525             


Leu Lys Ala His Ser Gln Arg Leu Val Asn Val Lys Ser Arg Leu Lys 
    530                 535                 540                 


Gln Ala Pro Arg Tyr Pro Ser Leu Ala Arg Glu Leu Ile Glu Tyr Gln 
545                 550                 555                 560 


Glu Arg Gln Leu Phe Glu Tyr Phe Val Val Val Ser Leu His Lys Lys 
                565                 570                 575     


Gln Ala Gly Ala Ala Tyr Val Pro Glu Leu Thr Gln Gln Phe Pro Leu 
            580                 585                 590         


Lys Leu Glu Arg Ser Phe Lys Phe Met Arg Glu Ala Glu Asp Gln Leu 
        595                 600                 605             


Lys Ala Ile Pro Gln Phe Cys Phe Pro Asp Ala Lys Asp Trp Val Pro 
    610                 615                 620                 


Val Gln Gln Phe Thr Ser Glu Thr Phe Ser Phe Val Leu Thr Gly Glu 
625                 630                 635                 640 


Asp Gly Ser Arg Arg Phe Gly Tyr Cys Arg Arg Leu Leu Pro Gly Gly 
                645                 650                 655     


Lys Gly Lys Arg Leu Pro Glu Val Tyr Cys Ile Val Ser Arg Leu Gly 
            660                 665                 670         


Cys Phe Ser Leu Phe Ser Arg Ile Leu Asp Glu Val Glu Lys Arg Arg 
        675                 680                 685             


Gly Ile Ser Pro Ala Leu Val Gln Pro Leu Met Arg Ser Val Met Glu 
    690                 695                 700                 


Ala Pro Phe Pro Ala Leu Gly Lys Thr Ile Leu Val Lys Asn Phe Leu 
705                 710                 715                 720 


Pro Gly Ser Gly Thr Glu Val Ile Glu Leu Cys Arg Pro Leu Asp Ser 
                725                 730                 735     


Arg Leu Glu His Val Asp Phe Glu Ser Leu Phe Ser Ser Leu Ser Val 
            740                 745                 750         


Arg His Leu Val Cys Val Phe Ala Ser Leu Leu Leu Glu Arg Arg Val 
        755                 760                 765             


Ile Phe Ile Ala Asp Lys Leu Ser Ile Leu Ser Lys Cys Cys His Ala 
    770                 775                 780                 


Met Val Ala Leu Ile Tyr Pro Phe Ala Trp Gln His Thr Tyr Ile Pro 
785                 790                 795                 800 


Val Leu Pro Pro Ala Met Val Asp Ile Val Cys Ser Pro Thr Pro Phe 
                805                 810                 815     


Leu Ile Gly Leu Leu Ser Ser Ser Leu Pro Leu Leu Arg Glu Leu Pro 
            820                 825                 830         


Leu Glu Glu Val Leu Val Val Asp Leu Val Asn Ser Arg Phe Leu Arg 
        835                 840                 845             


Gln Met Asp Asp Glu Asp Ser Ile Leu Pro Arg Lys Leu Gln Val Ala 
    850                 855                 860                 


Leu Glu His Ile Leu Glu Gln Arg Asn Glu Leu Ala Cys Glu Gln Asp 
865                 870                 875                 880 


Glu Gly Pro Leu Asp Gly Arg His Gly Pro Glu Ser Ser Pro Leu Asn 
                885                 890                 895     


Glu Val Val Ser Glu Ala Phe Val Arg Phe Phe Val Glu Ile Val Gly 
            900                 905                 910         


His Tyr Ser Leu Phe Leu Thr Ser Gly Glu Arg Glu Glu Arg Thr Leu 
        915                 920                 925             


Gln Arg Glu Ala Phe Arg Lys Ala Val Ser Ser Lys Ser Leu Arg His 
    930                 935                 940                 


Phe Leu Glu Val Phe Met Glu Thr Gln Met Phe Arg Gly Phe Ile Gln 
945                 950                 955                 960 


Glu Arg Glu Leu Arg Arg Gln Asp Ala Lys Gly Leu Phe Glu Val Arg 
                965                 970                 975     


Ala Gln Glu Tyr Leu Glu Thr Leu Pro Ser Gly Glu His Ser Gly Val 
            980                 985                 990         


Asn Lys Phe Leu Lys Gly Leu Gly  Asn Lys Met Lys Phe  Leu His Lys 
        995                 1000                 1005             


Lys 
    


<210>  3011
<211>  1906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENND4A__Homo_sapiens__NP_001138295

<400>  3011

Met Ile Glu Asp Lys Gly Pro Arg Val Ala Asp Tyr Phe Val Val Ala 
1               5                   10                  15      


Gly Leu Thr Asp Val Ser Lys Pro Leu Glu Glu Glu Ile His Phe Asn 
            20                  25                  30          


Asp Ala Cys His Lys Val Ala Lys Pro Lys Glu Pro Ile Thr Asp Val 
        35                  40                  45              


Ser Val Ile Ile Lys Ser Leu Gly Glu Glu Val Pro Gln Asp Tyr Ile 
    50                  55                  60                  


Cys Ile Asp Val Thr Pro Thr Gly Leu Ser Ala Asp Leu Asn Asn Gly 
65                  70                  75                  80  


Ser Leu Val Gly Pro Gln Ile Tyr Leu Cys Tyr Arg Arg Gly Arg Asp 
                85                  90                  95      


Lys Pro Pro Leu Thr Asp Leu Gly Val Leu Tyr Asp Trp Lys Glu Arg 
            100                 105                 110         


Leu Lys Gln Gly Cys Glu Ile Ile Gln Ser Thr Pro Tyr Gly Arg Pro 
        115                 120                 125             


Ala Asn Ile Ser Gly Ser Thr Ser Ser Gln Arg Ile Tyr Ile Thr Tyr 
    130                 135                 140                 


Arg Arg Ala Ser Glu Asn Met Thr Gln Asn Thr Leu Ala Val Thr Asp 
145                 150                 155                 160 


Ile Cys Ile Ile Ile Pro Ser Lys Gly Glu Ser Pro Pro His Thr Phe 
                165                 170                 175     


Cys Lys Val Asp Lys Asn Leu Asn Asn Ser Met Trp Gly Ser Ala Val 
            180                 185                 190         


Tyr Leu Cys Tyr Lys Lys Ser Val Ala Lys Thr Asn Thr Val Ser Tyr 
        195                 200                 205             


Lys Ala Gly Leu Ile Cys Arg Tyr Pro Gln Glu Asp Tyr Glu Ser Phe 
    210                 215                 220                 


Ser Leu Pro Glu Ser Val Pro Leu Phe Cys Leu Pro Met Gly Ala Thr 
225                 230                 235                 240 


Ile Glu Cys Trp Pro Ser Asn Ser Lys Tyr Pro Leu Pro Val Phe Ser 
                245                 250                 255     


Thr Phe Val Leu Thr Gly Ala Ser Ala Glu Lys Val Tyr Gly Ala Ala 
            260                 265                 270         


Ile Gln Phe Tyr Glu Pro Tyr Ser Glu Glu Asn Leu Thr Glu Lys Gln 
        275                 280                 285             


Arg Leu Leu Leu Gly Leu Thr Ser Ala Asp Gly Lys Ser Asp Ser Ser 
    290                 295                 300                 


Lys Thr Ile His Thr Asn Lys Cys Ile Cys Leu Leu Ser His Trp Pro 
305                 310                 315                 320 


Phe Phe Asp Ala Phe Arg Lys Phe Leu Thr Phe Leu Tyr Arg Tyr Ser 
                325                 330                 335     


Ile Ser Gly Pro His Val Leu Pro Ile Glu Lys His Ile Ser His Phe 
            340                 345                 350         


Met His Lys Val Pro Phe Pro Ser Pro Gln Arg Pro Arg Ile Leu Val 
        355                 360                 365             


Gln Leu Ser Pro His Asp Asn Leu Ile Leu Ser Gln Pro Val Ser Ser 
    370                 375                 380                 


Pro Leu Pro Leu Ser Gly Gly Lys Phe Ser Thr Leu Leu Gln Asn Leu 
385                 390                 395                 400 


Gly Pro Glu Asn Ala Val Thr Leu Leu Val Phe Ala Val Thr Glu His 
                405                 410                 415     


Lys Ile Leu Ile His Ser Leu Arg Pro Ser Val Leu Thr Ser Val Thr 
            420                 425                 430         


Glu Ala Leu Val Ser Met Ile Phe Pro Phe His Trp Pro Cys Pro Tyr 
        435                 440                 445             


Val Pro Leu Cys Pro Leu Ala Leu Ala Asp Val Leu Ser Ala Pro Cys 
    450                 455                 460                 


Pro Phe Ile Val Gly Ile Asp Ser Arg Tyr Phe Asp Leu Tyr Asp Pro 
465                 470                 475                 480 


Pro Pro Asp Val Ser Cys Val Asp Val Asp Thr Asn Thr Ile Ser Gln 
                485                 490                 495     


Ile Gly Asp Lys Lys Asn Val Ala Trp Lys Ile Leu Pro Lys Lys Pro 
            500                 505                 510         


Cys Lys Asn Leu Met Asn Thr Leu Asn Asn Leu His Gln Gln Leu Ala 
        515                 520                 525             


Lys Leu Gln Gln Arg Pro Arg Asp Asp Gly Leu Met Asp Leu Ala Ile 
    530                 535                 540                 


Asn Asp Tyr Asp Phe Asn Ser Gly Lys Arg Leu His Met Ile Asp Leu 
545                 550                 555                 560 


Glu Ile Gln Glu Ala Phe Leu Phe Phe Met Ala Ser Ile Leu Lys Gly 
                565                 570                 575     


Tyr Arg Ser Tyr Leu Arg Pro Ile Thr Gln Ala Pro Ser Glu Thr Ala 
            580                 585                 590         


Thr Asp Ala Ala Ser Leu Phe Ala Leu Gln Ala Phe Leu Arg Ser Arg 
        595                 600                 605             


Asp Arg Ser His Gln Lys Phe Tyr Asn Met Met Thr Lys Thr Gln Met 
    610                 615                 620                 


Phe Ile Arg Phe Ile Glu Glu Cys Ser Phe Val Ser Asp Lys Asp Ala 
625                 630                 635                 640 


Ser Leu Ala Phe Phe Asp Asp Cys Val Asp Lys Val Asp Met Asp Lys 
                645                 650                 655     


Ser Gly Glu Val Arg Leu Ile Glu Leu Asp Glu Ser Phe Lys Ser Glu 
            660                 665                 670         


His Thr Val Phe Val Thr Pro Pro Glu Ile Pro His Leu Pro Asn Gly 
        675                 680                 685             


Glu Glu Pro Pro Leu Gln Tyr Ser Tyr Asn Gly Phe Pro Val Leu Arg 
    690                 695                 700                 


Asn Asn Leu Phe Glu Arg Pro Glu Gly Phe Leu Gln Ala Lys Lys Asn 
705                 710                 715                 720 


Lys Leu Pro Ser Lys Ser Ser Ser Pro Asn Ser Pro Leu Pro Met Phe 
                725                 730                 735     


Arg Arg Thr Lys Gln Glu Ile Lys Ser Ala His Lys Ile Ala Lys Arg 
            740                 745                 750         


Tyr Ser Ser Ile Pro Gln Met Trp Ser Arg Cys Leu Leu Arg His Cys 
        755                 760                 765             


Tyr Gly Leu Trp Phe Ile Cys Leu Pro Ala Tyr Val Lys Val Cys His 
    770                 775                 780                 


Ser Lys Val Arg Ala Leu Lys Thr Ala Tyr Asp Val Leu Lys Lys Met 
785                 790                 795                 800 


Gln Ser Lys Lys Met Asp Pro Pro Asp Glu Val Cys Tyr Arg Ile Leu 
                805                 810                 815     


Met Gln Leu Cys Gly Gln Tyr Asp Gln Pro Val Leu Ala Val Arg Val 
            820                 825                 830         


Leu Phe Glu Met Gln Lys Ala Gly Ile Asp Pro Asn Ala Ile Thr Tyr 
        835                 840                 845             


Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Thr Trp Pro Ser Arg Ser 
    850                 855                 860                 


Arg Ser Gly Tyr Phe Leu Trp Thr Lys Val Arg Asn Val Val Leu Gly 
865                 870                 875                 880 


Val Thr Gln Phe Lys Arg Ala Leu Lys Lys His Ala His Leu Ser Gln 
                885                 890                 895     


Thr Thr Leu Ser Asp Gly Ser Asp Leu Asp Ala Val Ser His Gly Ser 
            900                 905                 910         


Met Asp Ser Gly His Gly Thr His Thr Val Glu Gln Ala Pro Phe Asn 
        915                 920                 925             


Thr Gly Leu Ile Lys Val Tyr Ala Thr Asp Asp Arg Ser Ser Thr Gly 
    930                 935                 940                 


Gly Gln Ser Asp Leu Gly Tyr Asn Ser Leu Ser Lys Asp Glu Val Arg 
945                 950                 955                 960 


Arg Gly Asp Thr Ser Thr Glu Asp Ile Gln Glu Glu Lys Asp Lys Lys 
                965                 970                 975     


Gly Ser Asp Cys Ser Ser Leu Ser Glu Ser Glu Ser Thr Lys Gly Ser 
            980                 985                 990         


Ala Asp Cys Leu Pro Lys Leu Ser  Tyr Gln Asn Ser Ser  Ser Ile Val 
        995                 1000                 1005             


Arg Leu  Thr Gly Thr Ser Asn  Asn Ser Ala Gly Lys  Ile Ser Gly 
    1010                 1015                 1020             


Glu Ser  Met Glu Ser Thr Pro  Glu Leu Leu Leu Ile  Ser Ser Leu 
    1025                 1030                 1035             


Glu Asp  Thr Asn Glu Thr Arg  Asn Ile Gln Ser Arg  Cys Phe Arg 
    1040                 1045                 1050             


Lys Arg  His Lys Ser Asp Asn  Glu Thr Asn Leu Gln  Gln Gln Val 
    1055                 1060                 1065             


Val Trp  Gly Asn Arg Asn Arg  Asn Leu Ser Gly Gly  Val Leu Met 
    1070                 1075                 1080             


Gly Phe  Met Leu Asn Arg Ile  Asn Gln Glu Ala Thr  Pro Gly Asp 
    1085                 1090                 1095             


Ile Val  Glu Lys Leu Gly Ala  Asp Ala Lys Ile Leu  Ser Asn Val 
    1100                 1105                 1110             


Ile Ser  Lys Ser Thr Arg Pro  Asn Thr Leu Asp Ile  Gly Lys Pro 
    1115                 1120                 1125             


Pro Leu  Arg Ser Lys Arg Asp  Ser Leu Glu Lys Glu  Ser Ser Asp 
    1130                 1135                 1140             


Asp Asp  Thr Pro Phe Asp Gly  Ser Asn Tyr Leu Ala  Asp Lys Val 
    1145                 1150                 1155             


Asp Ser  Pro Val Ile Phe Asp  Leu Glu Asp Leu Asp  Ser Glu Thr 
    1160                 1165                 1170             


Asp Val  Ser Lys Ala Gly Cys  Val Ala Thr Gln Asn  Pro Lys Arg 
    1175                 1180                 1185             


Ile Gln  Arg Met Asn Ser Ser  Phe Ser Val Lys Pro  Phe Glu Lys 
    1190                 1195                 1200             


Thr Asp  Val Ala Thr Gly Phe  Asp Pro Leu Ser Leu  Leu Val Ala 
    1205                 1210                 1215             


Glu Thr  Glu Gln Gln Gln Lys  Glu Glu Glu Glu Glu  Asp Glu Asp 
    1220                 1225                 1230             


Asp Ser  Lys Ser Ile Ser Thr  Pro Ser Ala Arg Arg  Asp Leu Ala 
    1235                 1240                 1245             


Glu Glu  Ile Val Met Tyr Met  Asn Asn Met Ser Ser  Pro Leu Thr 
    1250                 1255                 1260             


Ser Arg  Thr Pro Ser Ile Asp  Leu Gln Arg Ala Cys  Asp Asp Lys 
    1265                 1270                 1275             


Leu Asn  Lys Lys Ser Pro Pro  Leu Val Lys Ala Cys  Arg Arg Ser 
    1280                 1285                 1290             


Ser Leu  Pro Pro Asn Ser Pro  Lys Pro Val Arg Leu  Thr Lys Ser 
    1295                 1300                 1305             


Lys Ser  Tyr Thr Lys Ser Glu  Glu Lys Pro Arg Asp  Arg Leu Trp 
    1310                 1315                 1320             


Ser Ser  Pro Ala Phe Ser Pro  Thr Cys Pro Phe Arg  Glu Glu Ser 
    1325                 1330                 1335             


Gln Asp  Thr Leu Thr His Ser  Ser Pro Ser Phe Asn  Leu Asp Thr 
    1340                 1345                 1350             


Leu Leu  Val Pro Lys Leu Asp  Val Leu Arg Asn Ser  Met Phe Thr 
    1355                 1360                 1365             


Ala Gly  Lys Gly Val Ala Glu  Lys Ala Ser Lys Trp  Tyr Ser Arg 
    1370                 1375                 1380             


Phe Thr  Met Tyr Thr Thr Ser  Ser Lys Asp Gln Ser  Ser Asp Arg 
    1385                 1390                 1395             


Thr Ser  Leu Ser Ser Val Gly  Ala Gln Asp Ser Glu  Ser Thr Ser 
    1400                 1405                 1410             


Leu Thr  Asp Glu Asp Val Cys  His Glu Leu Glu Gly  Pro Ile Ser 
    1415                 1420                 1425             


Ser Gln  Glu Thr Ser Ala Thr  Ser Gly Thr Lys Arg  Ile Asp Leu 
    1430                 1435                 1440             


Ser Arg  Ile Ser Leu Glu Ser  Ser Ala Ser Leu Glu  Gly Ser Leu 
    1445                 1450                 1455             


Ser Lys  Phe Ala Leu Pro Gly  Lys Ser Glu Val Thr  Ser Ser Phe 
    1460                 1465                 1470             


Asn Ala  Ser Asn Thr Asn Ile  Phe Gln Asn Tyr Ala  Met Glu Val 
    1475                 1480                 1485             


Leu Ile  Ser Ser Cys Ser Arg  Cys Arg Thr Cys Asp  Cys Leu Val 
    1490                 1495                 1500             


His Asp  Glu Glu Ile Met Ala  Gly Trp Thr Ala Asp  Asp Ser Asn 
    1505                 1510                 1515             


Leu Asn  Thr Thr Cys Pro Phe  Cys Gly Asn Ile Phe  Leu Pro Phe 
    1520                 1525                 1530             


Leu Asn  Ile Glu Ile Arg Asp  Leu Arg Arg Pro Gly  Arg Tyr Phe 
    1535                 1540                 1545             


Leu Lys  Ser Ser Pro Ser Thr  Glu Asn Met His Phe  Pro Ser Ser 
    1550                 1555                 1560             


Ile Ser  Ser Gln Thr Arg Gln  Ser Cys Ile Ser Thr  Ser Ala Ser 
    1565                 1570                 1575             


Gly Leu  Asp Thr Ser Ala Leu  Ser Val Gln Gly Asn  Phe Asp Leu 
    1580                 1585                 1590             


Asn Ser  Lys Ser Lys Leu Gln  Glu Asn Phe Cys Thr  Arg Ser Ile 
    1595                 1600                 1605             


Gln Ile  Pro Ala Asn Arg Ser  Lys Thr Ala Met Ser  Lys Cys Pro 
    1610                 1615                 1620             


Ile Phe  Pro Met Ala Arg Ser  Ile Ser Thr Ser Gly  Pro Leu Asp 
    1625                 1630                 1635             


Lys Glu  Asp Thr Gly Arg Gln  Lys Leu Ile Ser Thr  Gly Ser Leu 
    1640                 1645                 1650             


Pro Ala  Thr Leu Gln Gly Ala  Thr Asp Ser Leu Gly  Leu Glu Trp 
    1655                 1660                 1665             


His Leu  Pro Ser Pro Asp Pro  Val Thr Val Pro Tyr  Leu Ser Pro 
    1670                 1675                 1680             


Leu Val  Val Trp Lys Glu Leu  Glu Ser Leu Leu Glu  Asn Glu Gly 
    1685                 1690                 1695             


Asp His  Ala Ile Thr Val Ala  Asp Phe Val Asp His  His Pro Ile 
    1700                 1705                 1710             


Val Phe  Trp Asn Leu Val Trp  Tyr Phe Arg Arg Leu  Asp Leu Pro 
    1715                 1720                 1725             


Ser Asn  Leu Pro Gly Leu Ile  Leu Ser Ser Glu His  Cys Asn Lys 
    1730                 1735                 1740             


Tyr Ser  Lys Ile Pro Arg His  Cys Met Ser Glu Asp  Ser Lys Tyr 
    1745                 1750                 1755             


Val Leu  Ile Gln Met Leu Trp  Asp Asn Met Lys Leu  His Gln Asp 
    1760                 1765                 1770             


Pro Gly  Gln Pro Leu Tyr Ile  Leu Trp Asn Ala His  Thr Gln Lys 
    1775                 1780                 1785             


Tyr Pro  Met Val His Leu Leu  Gln Lys Ser Asp Asn  Ser Phe Asn 
    1790                 1795                 1800             


Gln Glu  Leu Leu Lys Ser Met  Val Lys Ser Ile Lys  Met Asn Asp 
    1805                 1810                 1815             


Val Tyr  Gly Pro Met Ser Gln  Ile Leu Glu Thr Leu  Asn Lys Cys 
    1820                 1825                 1830             


Pro His  Phe Lys Arg Gln Arg  Ser Leu Tyr Arg Glu  Ile Leu Phe 
    1835                 1840                 1845             


Leu Ser  Leu Val Ala Leu Gly  Arg Glu Asn Ile Asp  Ile Asp Ala 
    1850                 1855                 1860             


Phe Asp  Lys Glu Tyr Lys Met  Ala Tyr Asp Arg Leu  Thr Pro Ser 
    1865                 1870                 1875             


Gln Val  Lys Ser Thr His Asn  Cys Asp Arg Pro Pro  Ser Thr Gly 
    1880                 1885                 1890             


Val Met  Glu Cys Arg Lys Thr  Phe Gly Glu Pro Tyr  Leu 
    1895                 1900                 1905     


<210>  3012
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENR__Homo_sapiens__NP_003668

<400>  3012

Met Ala Ala Asp Ile Ser Glu Ser Ser Gly Ala Asp Cys Lys Gly Asp 
1               5                   10                  15      


Pro Arg Asn Ser Ala Lys Leu Asp Ala Asp Tyr Pro Leu Arg Val Leu 
            20                  25                  30          


Tyr Cys Gly Val Cys Ser Leu Pro Thr Glu Tyr Cys Glu Tyr Met Pro 
        35                  40                  45              


Asp Val Ala Lys Cys Arg Gln Trp Leu Glu Lys Asn Phe Pro Asn Glu 
    50                  55                  60                  


Phe Ala Lys Leu Thr Val Glu Asn Ser Pro Lys Gln Glu Ala Gly Ile 
65                  70                  75                  80  


Ser Glu Gly Gln Gly Thr Ala Gly Glu Glu Glu Glu Lys Lys Lys Gln 
                85                  90                  95      


Lys Arg Gly Gly Arg Gly Gln Ile Lys Gln Lys Lys Lys Thr Val Pro 
            100                 105                 110         


Gln Lys Val Thr Ile Ala Lys Ile Pro Arg Ala Lys Lys Lys Tyr Val 
        115                 120                 125             


Thr Arg Val Cys Gly Leu Ala Thr Phe Glu Ile Asp Leu Lys Glu Ala 
    130                 135                 140                 


Gln Arg Phe Phe Ala Gln Lys Phe Ser Cys Gly Ala Ser Val Thr Gly 
145                 150                 155                 160 


Glu Asp Glu Ile Ile Ile Gln Gly Asp Phe Thr Asp Asp Ile Ile Asp 
                165                 170                 175     


Val Ile Gln Glu Lys Trp Pro Glu Val Asp Asp Asp Ser Ile Glu Asp 
            180                 185                 190         


Leu Gly Glu Val Lys Lys 
        195             


<210>  3013
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEPDC1B__Homo_sapiens__NP_001138680

<400>  3013

Met Glu His Arg Ile Val Gly Pro Gly Pro Tyr Arg Ala Thr Arg Leu 
1               5                   10                  15      


Trp Asn Glu Thr Val Glu Leu Phe Arg Ala Lys Met Pro Leu Arg Lys 
            20                  25                  30          


His Arg Cys Arg Phe Lys Ser Tyr Glu His Cys Phe Thr Ala Ala Glu 
        35                  40                  45              


Ala Val Asp Trp Leu His Glu Leu Leu Arg Cys Ser Gln Asn Phe Gly 
    50                  55                  60                  


Pro Glu Val Thr Arg Lys Gln Thr Val Gln Leu Leu Lys Lys Phe Leu 
65                  70                  75                  80  


Lys Asn His Val Ile Glu Asp Ile Lys Gly Lys Trp Gly Glu Glu Asp 
                85                  90                  95      


Phe Glu Asp Asn Arg His Leu Tyr Arg Phe Pro Pro Ser Ser Pro Leu 
            100                 105                 110         


Lys Pro Tyr Pro Lys Lys Pro Pro Asn Gln Lys Asp Val Ile Lys Phe 
        115                 120                 125             


Pro Glu Trp Asn Asp Leu Pro Pro Gly Thr Ser Gln Glu Asn Ile Pro 
    130                 135                 140                 


Val Arg Pro Val Val Met Asn Ser Glu Met Trp Tyr Lys Arg His Ser 
145                 150                 155                 160 


Ile Ala Ile Gly Glu Val Pro Ala Cys Arg Leu Val His Arg Arg Gln 
                165                 170                 175     


Leu Thr Glu Ala Asn Val Glu Glu Ile Trp Lys Ser Met Thr Leu Ser 
            180                 185                 190         


Tyr Leu Gln Lys Ile Leu Gly Leu Asp Ser Leu Glu Glu Val Leu Asp 
        195                 200                 205             


Val Lys Leu Val Asn Ser Lys Phe Ile Ile His Asn Val Tyr Ser Val 
    210                 215                 220                 


Ser Lys Gln Gly Val Val Ile Leu Asp Asp Lys Ser Lys Glu Leu Pro 
225                 230                 235                 240 


His Trp Val Leu Ser Ala Met Lys Cys Leu Ala Asn Trp Pro Asn Cys 
                245                 250                 255     


Ser Asp Leu Lys Gln Pro Met Tyr Leu Gly Phe Glu Lys Asp Val Phe 
            260                 265                 270         


Lys Thr Ile Ala Asp Tyr Tyr Gly His Leu Lys Glu Pro Leu Leu Thr 
        275                 280                 285             


Phe His Leu Phe Asp Ala Phe Val Ser Val Leu Gly Leu Leu Gln Lys 
    290                 295                 300                 


Glu Lys Val Ala Val Glu Ala Phe Gln Ile Cys Cys Leu Leu Leu Pro 
305                 310                 315                 320 


Pro Glu Asn Arg Arg Lys Leu Gln Leu Leu Met Arg Met Met Ala Arg 
                325                 330                 335     


Ile Cys Leu Asn Lys Glu Met Pro Pro Leu Cys Asp Gly Phe Gly Thr 
            340                 345                 350         


Arg Thr Leu Met Val Gln Thr Phe Ser Arg Cys Ile Leu Cys Ser Lys 
        355                 360                 365             


Asp Glu Val Asp Leu Asp Glu Leu Leu Ala Ala Arg Leu Val Thr Phe 
    370                 375                 380                 


Leu Met Asp Asn Tyr Gln Glu Ile Leu Lys Val Pro Leu Ala Leu Gln 
385                 390                 395                 400 


Thr Ser Ile Glu Glu Arg Val Ala His Leu Arg Arg Val Gln Phe Gln 
                405                 410                 415     


Lys Ser Tyr Pro Glu Val Tyr Gln Glu Arg Phe Pro Thr Pro Glu Ser 
            420                 425                 430         


Ala Ala Leu Leu Phe Pro Glu Lys Pro Lys Pro Lys Pro Gln Leu Leu 
        435                 440                 445             


Met Trp Ala Leu Lys Lys Pro Phe Gln Pro Phe Gln Arg Thr Arg Ser 
    450                 455                 460                 


Phe Arg Met 
465         


<210>  3014
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEPDC5__Homo_sapiens__NP_001007189

<400>  3014

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Glu His Leu Gly 
545                 550                 555                 


<210>  3015
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEPTOR__Homo_sapiens__NP_073620

<400>  3015

Met Glu Glu Gly Gly Ser Thr Gly Ser Ala Gly Ser Asp Ser Ser Thr 
1               5                   10                  15      


Ser Gly Ser Gly Gly Ala Gln Gln Arg Glu Leu Glu Arg Met Ala Glu 
            20                  25                  30          


Val Leu Val Thr Gly Glu Gln Leu Arg Leu Arg Leu His Glu Glu Lys 
        35                  40                  45              


Val Ile Lys Asp Arg Arg His His Leu Lys Thr Tyr Pro Asn Cys Phe 
    50                  55                  60                  


Val Ala Lys Glu Leu Ile Asp Trp Leu Ile Glu His Lys Glu Ala Ser 
65                  70                  75                  80  


Asp Arg Glu Thr Ala Ile Lys Leu Met Gln Lys Leu Ala Asp Arg Gly 
                85                  90                  95      


Ile Ile His His Val Cys Asp Glu His Lys Glu Phe Lys Asp Val Lys 
            100                 105                 110         


Leu Phe Tyr Arg Phe Arg Lys Asp Asp Gly Thr Phe Pro Leu Asp Asn 
        115                 120                 125             


Glu Val Lys Ala Phe Met Arg Gly Gln Arg Leu Tyr Glu Lys Leu Met 
    130                 135                 140                 


Ser Pro Glu Asn Thr Leu Leu Gln Pro Arg Glu Glu Glu Gly Val Lys 
145                 150                 155                 160 


Tyr Glu Arg Thr Phe Met Ala Ser Glu Phe Leu Asp Trp Leu Val Gln 
                165                 170                 175     


Glu Gly Glu Ala Thr Thr Arg Lys Glu Ala Glu Gln Leu Cys His Arg 
            180                 185                 190         


Leu Met Glu His Gly Ile Ile Gln His Val Ser Asn Lys His Pro Phe 
        195                 200                 205             


Val Asp Ser Asn Leu Leu Tyr Gln Phe Arg Met Asn Phe Arg Arg Arg 
    210                 215                 220                 


Arg Arg Leu Met Glu Leu Leu Asn Glu Lys Ser Pro Ser Ser Gln Glu 
225                 230                 235                 240 


Thr His Asp Ser Pro Phe Cys Leu Arg Lys Gln Ser His Asp Asn Arg 
                245                 250                 255     


Lys Ser Thr Ser Phe Met Ser Val Ser Pro Ser Lys Glu Ile Lys Ile 
            260                 265                 270         


Val Ser Ala Val Arg Arg Ser Ser Met Ser Ser Cys Gly Ser Ser Gly 
        275                 280                 285             


Tyr Phe Ser Ser Ser Pro Thr Leu Ser Ser Ser Pro Pro Val Leu Cys 
    290                 295                 300                 


Asn Pro Lys Ser Val Leu Lys Arg Pro Val Thr Ser Glu Glu Leu Leu 
305                 310                 315                 320 


Thr Pro Gly Ala Pro Tyr Ala Arg Lys Thr Phe Thr Ile Val Gly Asp 
                325                 330                 335     


Ala Val Gly Trp Gly Phe Val Val Arg Gly Ser Lys Pro Cys His Ile 
            340                 345                 350         


Gln Ala Val Asp Pro Ser Gly Pro Ala Ala Ala Ala Gly Met Lys Val 
        355                 360                 365             


Cys Gln Phe Val Val Ser Val Asn Gly Leu Asn Val Leu His Val Asp 
    370                 375                 380                 


Tyr Arg Thr Val Ser Asn Leu Ile Leu Thr Gly Pro Arg Thr Ile Val 
385                 390                 395                 400 


Met Glu Val Met Glu Glu Leu Glu Cys 
                405                 


<210>  3016
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DERA__Homo_sapiens__NP_057038

<400>  3016

Met Ser Ala His Asn Arg Gly Thr Glu Leu Asp Leu Ser Trp Ile Ser 
1               5                   10                  15      


Lys Ile Gln Val Asn His Pro Ala Val Leu Arg Arg Ala Glu Gln Ile 
            20                  25                  30          


Gln Ala Arg Arg Thr Val Lys Lys Glu Trp Gln Ala Ala Trp Leu Leu 
        35                  40                  45              


Lys Ala Val Thr Phe Ile Asp Leu Thr Thr Leu Ser Gly Asp Asp Thr 
    50                  55                  60                  


Ser Ser Asn Ile Gln Arg Leu Cys Tyr Lys Ala Lys Tyr Pro Ile Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Lys Ala Leu Asn Met His Asp Lys Gly Ile Thr Thr 
                85                  90                  95      


Ala Ala Val Cys Val Tyr Pro Ala Arg Val Cys Asp Ala Val Lys Ala 
            100                 105                 110         


Leu Lys Ala Ala Gly Cys Asn Ile Pro Val Ala Ser Val Ala Ala Gly 
        115                 120                 125             


Phe Pro Ala Gly Gln Thr His Leu Lys Thr Arg Leu Glu Glu Ile Arg 
    130                 135                 140                 


Leu Ala Val Glu Asp Gly Ala Thr Glu Ile Asp Val Val Ile Asn Arg 
145                 150                 155                 160 


Ser Leu Val Leu Thr Gly Gln Trp Glu Ala Leu Tyr Asp Glu Ile Arg 
                165                 170                 175     


Gln Phe Arg Lys Ala Cys Gly Glu Ala His Leu Lys Thr Ile Leu Ala 
            180                 185                 190         


Thr Gly Glu Leu Gly Thr Leu Thr Asn Val Tyr Lys Ala Ser Met Ile 
        195                 200                 205             


Ala Met Met Ala Gly Ser Asp Phe Ile Lys Thr Ser Thr Gly Lys Glu 
    210                 215                 220                 


Thr Val Asn Ala Thr Phe Pro Val Ala Ile Val Met Leu Arg Ala Ile 
225                 230                 235                 240 


Arg Asp Phe Phe Trp Lys Thr Gly Asn Lys Ile Gly Phe Lys Pro Ala 
                245                 250                 255     


Gly Gly Ile Arg Ser Ala Lys Asp Ser Leu Ala Trp Leu Ser Leu Val 
            260                 265                 270         


Lys Glu Glu Leu Gly Asp Glu Trp Leu Lys Pro Glu Leu Phe Arg Ile 
        275                 280                 285             


Gly Ala Ser Thr Leu Leu Ser Asp Ile Glu Arg Gln Ile Tyr His His 
    290                 295                 300                 


Val Thr Gly Arg Tyr Ala Ala Tyr His Asp Leu Pro Met Ser 
305                 310                 315             


<210>  3017
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DERL1__Homo_sapiens__NP_001128143

<400>  3017

Met Ser Asp Ile Gly Asp Trp Phe Arg Ser Ile Pro Ala Ile Thr Arg 
1               5                   10                  15      


Tyr Trp Phe Ala Ala Thr Val Ala Val Pro Leu Val Gly Lys Leu Gly 
            20                  25                  30          


Leu Ile Ser Pro Ala Tyr Leu Phe Leu Trp Pro Glu Ala Phe Leu Tyr 
        35                  40                  45              


Arg Phe Gln Ile Trp Arg Pro Ile Thr Ala Thr Phe Tyr Phe Pro Val 
    50                  55                  60                  


Gly Pro Gly Thr Gly Phe Leu Tyr Leu Val Asn Leu Tyr Phe Leu Tyr 
65                  70                  75                  80  


Gln Tyr Ser Thr Arg Leu Glu Thr Gly Ala Phe Asp Gly Arg Pro Ala 
                85                  90                  95      


Asp Tyr Leu Phe Met Leu Leu Phe Asn Trp Ile Cys Ile Val Ile Thr 
            100                 105                 110         


Gly Leu Ala Met Asp Met Gln Leu Leu Met Ile Pro Leu Ile Met Ser 
        115                 120                 125             


Val Leu Tyr Val Trp Ala Gln Leu Asn Arg Asp Met Ile Val Ser Phe 
    130                 135                 140                 


Trp Phe Gly Thr Arg Phe Lys Ala Cys Tyr Leu Pro Trp Val Ile Leu 
145                 150                 155                 160 


Gly Phe Asn Tyr Ile Ile Gly Gly Ser Tyr Pro Met Asp Leu Gly Gly 
                165                 170                 175     


Arg Asn Phe Leu Ser Thr Pro Gln Phe Leu Tyr Arg Trp Leu Pro Ser 
            180                 185                 190         


Arg Arg Gly Gly Val Ser Gly Phe Gly Val Pro Pro Ala Ser Met Arg 
        195                 200                 205             


Arg Ala Ala Asp Gln Asn Gly Gly Gly Gly Arg His Asn Trp Gly Gln 
    210                 215                 220                 


Gly Phe Arg Leu Gly Asp Gln 
225                 230     


<210>  3018
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DERL2__Homo_sapiens__NP_057125

<400>  3018

Met Ala Tyr Gln Ser Leu Arg Leu Glu Tyr Leu Gln Ile Pro Pro Val 
1               5                   10                  15      


Ser Arg Ala Tyr Thr Thr Ala Cys Val Leu Thr Thr Ala Ala Val Gln 
            20                  25                  30          


Leu Glu Leu Ile Thr Pro Phe Gln Leu Tyr Phe Asn Pro Glu Leu Ile 
        35                  40                  45              


Phe Lys His Phe Gln Ile Trp Arg Leu Ile Thr Asn Phe Leu Phe Phe 
    50                  55                  60                  


Gly Pro Val Gly Phe Asn Phe Leu Phe Asn Met Ile Phe Leu Tyr Arg 
65                  70                  75                  80  


Tyr Cys Arg Met Leu Glu Glu Gly Ser Phe Arg Gly Arg Thr Ala Asp 
                85                  90                  95      


Phe Val Phe Met Phe Leu Phe Gly Gly Phe Leu Met Thr Leu Phe Gly 
            100                 105                 110         


Leu Phe Val Ser Leu Val Phe Leu Gly Gln Ala Phe Thr Ile Met Leu 
        115                 120                 125             


Val Tyr Val Trp Ser Arg Arg Asn Pro Tyr Val Arg Met Asn Phe Phe 
    130                 135                 140                 


Gly Leu Leu Asn Phe Gln Ala Pro Phe Leu Pro Trp Val Leu Met Gly 
145                 150                 155                 160 


Phe Ser Leu Leu Leu Gly Asn Ser Ile Ile Val Asp Leu Leu Gly Ile 
                165                 170                 175     


Ala Val Gly His Ile Tyr Phe Phe Leu Glu Asp Val Phe Pro Asn Gln 
            180                 185                 190         


Pro Gly Gly Ile Arg Ile Leu Lys Thr Pro Ser Ile Leu Lys Ala Ile 
        195                 200                 205             


Phe Asp Thr Pro Asp Glu Asp Pro Asn Tyr Asn Pro Leu Pro Glu Glu 
    210                 215                 220                 


Arg Pro Gly Gly Phe Ala Trp Gly Glu Gly Gln Arg Leu Gly Gly 
225                 230                 235                 


<210>  3019
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DERL3__Homo_sapiens__NP_001002862

<400>  3019

Met Ala Trp Gln Gly Leu Ala Ala Glu Phe Leu Gln Val Pro Ala Val 
1               5                   10                  15      


Thr Arg Ala Tyr Thr Ala Ala Cys Val Leu Thr Thr Ala Ala Val Gln 
            20                  25                  30          


Leu Glu Leu Leu Ser Pro Phe Gln Leu Tyr Phe Asn Pro His Leu Val 
        35                  40                  45              


Phe Arg Lys Phe Gln Val Trp Arg Leu Val Thr Asn Phe Leu Phe Phe 
    50                  55                  60                  


Gly Pro Leu Gly Phe Ser Phe Phe Phe Asn Met Leu Phe Val Phe Arg 
65                  70                  75                  80  


Tyr Cys Arg Met Leu Glu Glu Gly Ser Phe Arg Gly Arg Thr Ala Asp 
                85                  90                  95      


Phe Val Phe Met Phe Leu Phe Gly Gly Val Leu Met Thr Leu Leu Gly 
            100                 105                 110         


Leu Leu Gly Ser Leu Phe Phe Leu Gly Gln Ala Leu Met Ala Met Leu 
        115                 120                 125             


Val Tyr Val Trp Ser Arg Arg Ser Pro Arg Val Arg Val Asn Phe Phe 
    130                 135                 140                 


Gly Leu Leu Thr Phe Gln Ala Pro Phe Leu Pro Trp Ala Leu Met Gly 
145                 150                 155                 160 


Phe Ser Leu Leu Leu Gly Asn Ser Ile Leu Val Asp Leu Leu Gly Ile 
                165                 170                 175     


Ala Val Gly His Ile Tyr Tyr Phe Leu Glu Asp Val Phe Pro Asn Gln 
            180                 185                 190         


Pro Gly Gly Lys Arg Leu Leu Gln Thr Pro Gly Phe Leu Lys Leu Leu 
        195                 200                 205             


Leu Asp Ala Pro Ala Glu Asp Pro Asn Tyr Leu Pro Leu Pro Glu Glu 
    210                 215                 220                 


Gln Pro Gly Pro His Leu Pro Pro Pro Gln Gln 
225                 230                 235 


<210>  3020
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DES__Homo_sapiens__NP_001918

<400>  3020

Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg 
1               5                   10                  15      


Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser 
            20                  25                  30          


Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser 
        35                  40                  45              


Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly 
    50                  55                  60                  


Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro 
65                  70                  75                  80  


Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala 
                85                  90                  95      


Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu 
            100                 105                 110         


Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe 
        115                 120                 125             


Leu Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys 
    130                 135                 140                 


Gly Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg 
145                 150                 155                 160 


Glu Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val 
                165                 170                 175     


Asp Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala 
            180                 185                 190         


Lys Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu 
        195                 200                 205             


Ala Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp 
    210                 215                 220                 


Leu Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys 
225                 230                 235                 240 


Lys Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu 
                245                 250                 255     


Gln Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala 
            260                 265                 270         


Ala Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn 
        275                 280                 285             


Ile Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr 
    290                 295                 300                 


Gln Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu 
305                 310                 315                 320 


Met Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp 
                325                 330                 335     


Ala Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu 
            340                 345                 350         


Glu Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala 
        355                 360                 365             


Arg Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His 
    370                 375                 380                 


Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val 
385                 390                 395                 400 


Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile 
                405                 410                 415     


Asn Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser 
            420                 425                 430         


Pro Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile 
        435                 440                 445             


Lys Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln 
    450                 455                 460                 


Gln Gln His Glu Val Leu 
465                 470 


<210>  3021
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DESI2__Homo_sapiens__NP_001284675

<400>  3021

Met Gly Ala Asn Gln Leu Val Val Leu Asn Val Tyr Asp Met Tyr Trp 
1               5                   10                  15      


Met Asn Glu Tyr Thr Ser Ser Ile Gly Ile Gly Val Phe His Ser Gly 
            20                  25                  30          


Ile Glu Val Tyr Gly Arg Ala Val Val Leu Gly Ser Thr Asp Phe Leu 
        35                  40                  45              


Glu Asp Asp Ile Glu Lys Ile Val Glu Glu Leu Gly Lys Glu Tyr Lys 
    50                  55                  60                  


Gly Asn Ala Tyr His Leu Met His Lys Asn Cys Asn His Phe Ser Ser 
65                  70                  75                  80  


Ala Leu Ser Glu Ile Leu Cys Gly Lys Glu Ile Pro Arg Trp Ile Asn 
                85                  90                  95      


Arg Leu Ala Tyr Phe Ser Ser Cys Ile Pro Phe Leu Gln Ser Cys Leu 
            100                 105                 110         


Pro Lys Glu Trp Leu Thr Pro Ala Ala Leu Gln Ser Ser Val Ser Gln 
        115                 120                 125             


Glu Leu Gln Asp Glu Leu Glu Glu Ala Glu Asp Ala Ala Ala Ser Ala 
    130                 135                 140                 


Ser Val Ala Ser Thr Ala Ala Gly Ser Arg Pro Gly Arg His Thr Lys 
145                 150                 155                 160 


Leu 
    


<210>  3022
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEXI__Homo_sapiens__NP_054734

<400>  3022

Met Leu Gly Ala Arg Val Ala Ala His Leu Asp Ala Leu Gly Pro Leu 
1               5                   10                  15      


Val Pro Tyr Val Pro Pro Pro Leu Leu Pro Ser Met Phe Tyr Val Gly 
            20                  25                  30          


Leu Phe Phe Val Asn Val Leu Ile Leu Tyr Tyr Ala Phe Leu Met Glu 
        35                  40                  45              


Tyr Ile Val Leu Asn Val Gly Leu Val Phe Leu Pro Glu Asp Met Asp 
    50                  55                  60                  


Gln Ala Leu Val Asp Leu Gly Val Leu Ser Asp Pro Gly Ser Gly Leu 
65                  70                  75                  80  


Tyr Asp Ala Asp Ser Glu Leu Asp Val Phe Asp Ala Tyr Leu Glu 
                85                  90                  95  


<210>  3023
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DFFB__Homo_sapiens__XP_011539165

<400>  3023

Met Leu Gln Lys Pro Lys Ser Val Lys Leu Arg Ala Leu Arg Ser Pro 
1               5                   10                  15      


Arg Lys Phe Gly Val Ala Gly Arg Ser Cys Gln Glu Val Leu Arg Lys 
            20                  25                  30          


Gly Cys Leu Arg Phe Gln Leu Pro Glu Arg Gly Ser Arg Leu Cys Leu 
        35                  40                  45              


Tyr Glu Asp Gly Thr Glu Leu Thr Glu Asp Tyr Phe Pro Ser Val Pro 
    50                  55                  60                  


Asp Asn Ala Glu Leu Val Leu Leu Thr Leu Gly Gln Ala Trp Gln Gly 
65                  70                  75                  80  


Cys Glu Trp Gln Gly Leu Trp Arg Met Cys Leu Leu Leu Asp Arg His 
                85                  90                  95      


Leu Leu Phe Val Pro Leu Val Ala Asp Val Ser Asp Ile Arg Arg Phe 
            100                 105                 110         


Leu Ser Ala Phe His Glu Pro Gln Val Gly Leu Ile Gln Ala Ala Gln 
        115                 120                 125             


Gln Leu Leu Cys Asp Glu Gln Ala Pro Gln Arg Gln Arg Leu Leu Ala 
    130                 135                 140                 


Asp Leu Leu His Asn Val Ser Gln Asn Ile Ala Ala Glu Thr Arg Ala 
145                 150                 155                 160 


Glu Asp Pro Pro Trp Phe Glu Gly Leu Glu Ser Arg Phe Gln Ser Lys 
                165                 170                 175     


Ser Gly Tyr Leu Arg Tyr Ser Cys Glu Ser Arg Ile Arg Ser Tyr Leu 
            180                 185                 190         


Arg Glu Val Ser Ser Tyr Pro Ser Thr Val Gly Ala Glu Ala Gln Glu 
        195                 200                 205             


Glu Phe Leu Arg Val Leu Gly Ser Met Cys Gln Arg Leu Arg Ser Met 
    210                 215                 220                 


Gln Tyr Asn Gly Ser Tyr Phe Asp Arg Gly Ala Lys Gly Gly Ser Arg 
225                 230                 235                 240 


Leu Cys Thr Pro Glu Gly Trp Phe Ser Cys Gln Gly Pro Phe Asp Met 
                245                 250                 255     


Asp Ser Cys Leu Ser Arg His Ser Ile Asn Pro Tyr Ser Asn Arg Glu 
            260                 265                 270         


Ser Arg Ile Leu Phe Ser Thr Trp Asn Leu Asp His Ile Asp Gly Val 
        275                 280                 285             


Leu Leu Cys Gly Pro Gly 
    290                 


<210>  3024
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DFNA5__Homo_sapiens__NP_001120925

<400>  3024

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser 
                325                 330                 335     


Gly Leu Ser Pro Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln 
            340                 345                 350         


Gln Gln Asp Leu Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln 
        355                 360                 365             


Gly Gly Cys Pro Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met 
    370                 375                 380                 


Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala 
385                 390                 395                 400 


Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu 
                405                 410                 415     


Cys His Leu Leu Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu 
            420                 425                 430         


Asp Pro Thr Leu Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val 
        435                 440                 445             


Gln Arg Leu Phe Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser 
    450                 455                 460                 


Ser Val Lys Ala Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu 
465                 470                 475                 480 


Leu Cys Ile Thr Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                485                 490                 495     


<210>  3025
<211>  907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DFNB31__Homo_sapiens__NP_056219

<400>  3025

Met Asn Ala Pro Leu Asp Gly Leu Ser Val Ser Ser Ser Ser Thr Gly 
1               5                   10                  15      


Ser Leu Gly Ser Ala Ala Gly Ala Gly Gly Gly Gly Gly Ala Gly Leu 
            20                  25                  30          


Arg Leu Leu Ser Ala Asn Val Arg Gln Leu His Gln Ala Leu Thr Ala 
        35                  40                  45              


Leu Leu Ser Glu Ala Glu Arg Glu Gln Phe Thr His Cys Leu Asn Ala 
    50                  55                  60                  


Tyr His Ala Arg Arg Asn Val Phe Asp Leu Val Arg Thr Leu Arg Val 
65                  70                  75                  80  


Leu Leu Asp Ser Pro Val Lys Arg Arg Leu Leu Pro Met Leu Arg Leu 
                85                  90                  95      


Val Ile Pro Arg Ser Asp Gln Leu Leu Phe Asp Gln Tyr Thr Ala Glu 
            100                 105                 110         


Gly Leu Tyr Leu Pro Ala Thr Thr Pro Tyr Arg Gln Pro Ala Trp Gly 
        115                 120                 125             


Gly Pro Asp Ser Ala Gly Pro Gly Glu Val Arg Leu Val Ser Leu Arg 
    130                 135                 140                 


Arg Ala Lys Ala His Glu Gly Leu Gly Phe Ser Ile Arg Gly Gly Ser 
145                 150                 155                 160 


Glu His Gly Val Gly Ile Tyr Val Ser Leu Val Glu Pro Gly Ser Leu 
                165                 170                 175     


Ala Glu Lys Glu Gly Leu Arg Val Gly Asp Gln Ile Leu Arg Val Asn 
            180                 185                 190         


Asp Lys Ser Leu Ala Arg Val Thr His Ala Glu Ala Val Lys Ala Leu 
        195                 200                 205             


Lys Gly Ser Lys Lys Leu Val Leu Ser Val Tyr Ser Ala Gly Arg Ile 
    210                 215                 220                 


Pro Gly Gly Tyr Val Thr Asn His Ile Tyr Thr Trp Val Asp Pro Gln 
225                 230                 235                 240 


Gly Arg Ser Ile Ser Pro Pro Ser Gly Leu Pro Gln Pro His Gly Gly 
                245                 250                 255     


Ala Leu Arg Gln Gln Glu Gly Asp Arg Arg Ser Thr Leu His Leu Leu 
            260                 265                 270         


Gln Gly Gly Asp Glu Lys Lys Val Asn Leu Val Leu Gly Asp Gly Arg 
        275                 280                 285             


Ser Leu Gly Leu Thr Ile Arg Gly Gly Ala Glu Tyr Gly Leu Gly Ile 
    290                 295                 300                 


Tyr Ile Thr Gly Val Asp Pro Gly Ser Glu Ala Glu Gly Ser Gly Leu 
305                 310                 315                 320 


Lys Val Gly Asp Gln Ile Leu Glu Val Asn Gly Arg Ser Phe Leu Asn 
                325                 330                 335     


Ile Leu His Asp Glu Ala Val Arg Leu Leu Lys Ser Ser Arg His Leu 
            340                 345                 350         


Ile Leu Thr Val Lys Asp Val Gly Arg Leu Pro His Ala Arg Thr Thr 
        355                 360                 365             


Val Asp Glu Thr Lys Trp Ile Ala Ser Ser Arg Ile Arg Glu Thr Met 
    370                 375                 380                 


Ala Asn Ser Ala Gly Phe Leu Gly Asp Leu Thr Thr Glu Gly Ile Asn 
385                 390                 395                 400 


Lys Pro Gly Phe Tyr Lys Gly Pro Ala Gly Ser Gln Val Thr Leu Ser 
                405                 410                 415     


Ser Leu Gly Asn Gln Thr Arg Val Leu Leu Glu Glu Gln Ala Arg His 
            420                 425                 430         


Leu Leu Asn Glu Gln Glu His Ala Thr Met Ala Tyr Tyr Leu Asp Glu 
        435                 440                 445             


Tyr Arg Gly Gly Ser Val Ser Val Glu Ala Leu Val Met Ala Leu Phe 
    450                 455                 460                 


Lys Leu Leu Asn Thr His Ala Lys Phe Ser Leu Leu Ser Glu Val Arg 
465                 470                 475                 480 


Gly Thr Ile Ser Pro Gln Asp Leu Glu Arg Phe Asp His Leu Val Leu 
                485                 490                 495     


Arg Arg Glu Ile Glu Ser Met Lys Ala Arg Gln Pro Pro Gly Pro Gly 
            500                 505                 510         


Ala Gly Asp Thr Tyr Ser Met Val Ser Tyr Ser Asp Thr Gly Ser Ser 
        515                 520                 525             


Thr Gly Ser His Gly Thr Ser Thr Thr Val Ser Ser Ala Arg Asn Thr 
    530                 535                 540                 


Leu Asp Leu Glu Glu Thr Gly Glu Ala Val Gln Gly Asn Ile Asn Ala 
545                 550                 555                 560 


Leu Pro Asp Val Ser Val Asp Asp Val Arg Ser Thr Ser Gln Gly Leu 
                565                 570                 575     


Ser Ser Phe Lys Pro Leu Pro Arg Pro Pro Pro Leu Ala Gln Gly Asn 
            580                 585                 590         


Asp Leu Pro Leu Gly Gln Pro Arg Lys Leu Gly Arg Glu Asp Leu Gln 
        595                 600                 605             


Pro Pro Ser Ser Met Pro Ser Cys Ser Gly Thr Val Phe Ser Ala Pro 
    610                 615                 620                 


Gln Asn Arg Ser Pro Pro Ala Gly Thr Ala Pro Thr Pro Gly Thr Ser 
625                 630                 635                 640 


Ser Ala Gln Asp Leu Pro Ser Ser Pro Ile Tyr Ala Ser Val Ser Pro 
                645                 650                 655     


Ala Asn Pro Ser Ser Lys Arg Pro Leu Asp Ala His Leu Ala Leu Val 
            660                 665                 670         


Asn Gln His Pro Ile Gly Pro Phe Pro Arg Val Gln Ser Pro Pro His 
        675                 680                 685             


Leu Lys Ser Pro Ser Ala Glu Ala Thr Val Ala Gly Gly Cys Leu Leu 
    690                 695                 700                 


Pro Pro Ser Pro Ser Gly His Pro Asp Gln Thr Gly Thr Asn Gln His 
705                 710                 715                 720 


Phe Val Met Val Glu Val His Arg Pro Asp Ser Glu Pro Asp Val Asn 
                725                 730                 735     


Glu Val Arg Ala Leu Pro Gln Thr Arg Thr Ala Ser Thr Leu Ser Gln 
            740                 745                 750         


Leu Ser Asp Ser Gly Gln Thr Leu Ser Glu Asp Ser Gly Val Asp Ala 
        755                 760                 765             


Gly Glu Ala Glu Ala Ser Ala Pro Gly Arg Gly Arg Gln Ser Val Ser 
    770                 775                 780                 


Thr Lys Ser Arg Ser Ser Lys Glu Leu Pro Arg Asn Glu Arg Pro Thr 
785                 790                 795                 800 


Asp Gly Ala Asn Lys Pro Pro Gly Leu Leu Glu Pro Thr Ser Thr Leu 
                805                 810                 815     


Val Arg Val Lys Lys Ser Ala Ala Thr Leu Gly Ile Ala Ile Glu Gly 
            820                 825                 830         


Gly Ala Asn Thr Arg Gln Pro Leu Pro Arg Ile Val Thr Ile Gln Arg 
        835                 840                 845             


Gly Gly Ser Ala His Asn Cys Gly Gln Leu Lys Val Gly His Val Ile 
    850                 855                 860                 


Leu Glu Val Asn Gly Leu Thr Leu Arg Gly Lys Glu His Arg Glu Ala 
865                 870                 875                 880 


Ala Arg Ile Ile Ala Glu Ala Phe Lys Thr Lys Asp Arg Asp Tyr Ile 
                885                 890                 895     


Asp Phe Leu Val Thr Glu Phe Asn Val Met Leu 
            900                 905         


<210>  3026
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DFNB59__Homo_sapiens__NP_001036167

<400>  3026

Met Phe Ala Ala Ala Thr Lys Ser Phe Val Lys Gln Val Gly Asp Gly 
1               5                   10                  15      


Gly Arg Leu Val Pro Val Pro Ser Leu Ser Glu Ala Asp Lys Tyr Gln 
            20                  25                  30          


Pro Leu Ser Leu Val Val Lys Lys Lys Arg Cys Phe Leu Phe Pro Arg 
        35                  40                  45              


Tyr Lys Phe Thr Ser Thr Pro Phe Thr Leu Lys Asp Ile Leu Leu Gly 
    50                  55                  60                  


Asp Arg Glu Ile Ser Ala Gly Ile Ser Ser Tyr Gln Leu Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Glu Ser Asp Val Ser Leu Tyr Gly Arg Arg Gly Asn His Ile 
                85                  90                  95      


Val Asn Asp Val Gly Ile Asn Val Ala Gly Ser Asp Ser Ile Ala Val 
            100                 105                 110         


Lys Ala Ser Phe Gly Ile Val Thr Lys His Glu Val Glu Val Ser Thr 
        115                 120                 125             


Leu Leu Lys Glu Ile Thr Thr Arg Lys Ile Asn Phe Asp His Ser Leu 
    130                 135                 140                 


Ile Arg Gln Ser Arg Ser Ser Arg Lys Ala Val Leu Cys Val Val Met 
145                 150                 155                 160 


Glu Ser Ile Arg Thr Thr Arg Gln Cys Ser Leu Ser Val His Ala Gly 
                165                 170                 175     


Ile Arg Gly Glu Ala Met Arg Phe His Phe Met Asp Glu Gln Asn Pro 
            180                 185                 190         


Lys Gly Arg Asp Lys Ala Ile Val Phe Pro Ala His Thr Thr Ile Ala 
        195                 200                 205             


Phe Ser Val Phe Glu Leu Phe Ile Tyr Leu Asp Gly Ala Phe Asp Leu 
    210                 215                 220                 


Cys Val Thr Ser Val Ser Lys Gly Gly Phe Glu Arg Glu Glu Thr Ala 
225                 230                 235                 240 


Thr Phe Ala Leu Leu Tyr Arg Leu Arg Asn Ile Leu Phe Glu Arg Asn 
                245                 250                 255     


Arg Arg Val Met Asp Val Ile Ser Arg Ser Gln Leu Tyr Leu Asp Asp 
            260                 265                 270         


Leu Phe Ser Asp Tyr Tyr Asp Lys Pro Leu Ser Met Thr Asp Ile Ser 
        275                 280                 285             


Leu Lys Glu Gly Thr His Ile Arg Val Asn Leu Leu Asn His Asn Ile 
    290                 295                 300                 


Pro Lys Gly Pro Cys Ile Leu Cys Gly Met Gly Asn Phe Lys Arg Glu 
305                 310                 315                 320 


Thr Val Tyr Gly Cys Phe Gln Cys Ser Val Asp Gly Gln Lys Tyr Val 
                325                 330                 335     


Arg Leu His Ala Val Pro Cys Phe Asp Ile Trp His Lys Arg Met Lys 
            340                 345                 350         


<210>  3027
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGAT1__Homo_sapiens__NP_036211

<400>  3027

Met Gly Asp Arg Gly Ser Ser Arg Arg Arg Arg Thr Gly Ser Arg Pro 
1               5                   10                  15      


Ser Ser His Gly Gly Gly Gly Pro Ala Ala Ala Glu Glu Glu Val Arg 
            20                  25                  30          


Asp Ala Ala Ala Gly Pro Asp Val Gly Ala Ala Gly Asp Ala Pro Ala 
        35                  40                  45              


Pro Ala Pro Asn Lys Asp Gly Asp Ala Gly Val Gly Ser Gly His Trp 
    50                  55                  60                  


Glu Leu Arg Cys His Arg Leu Gln Asp Ser Leu Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Gly Phe Ser Asn Tyr Arg Gly Ile Leu Asn Trp Cys Val Val Met Leu 
                85                  90                  95      


Ile Leu Ser Asn Ala Arg Leu Phe Leu Glu Asn Leu Ile Lys Tyr Gly 
            100                 105                 110         


Ile Leu Val Asp Pro Ile Gln Val Val Ser Leu Phe Leu Lys Asp Pro 
        115                 120                 125             


Tyr Ser Trp Pro Ala Pro Cys Leu Val Ile Ala Ala Asn Val Phe Ala 
    130                 135                 140                 


Val Ala Ala Phe Gln Val Glu Lys Arg Leu Ala Val Gly Ala Leu Thr 
145                 150                 155                 160 


Glu Gln Ala Gly Leu Leu Leu His Val Ala Asn Leu Ala Thr Ile Leu 
                165                 170                 175     


Cys Phe Pro Ala Ala Val Val Leu Leu Val Glu Ser Ile Thr Pro Val 
            180                 185                 190         


Gly Ser Leu Leu Ala Leu Met Ala His Thr Ile Leu Phe Leu Lys Leu 
        195                 200                 205             


Phe Ser Tyr Arg Asp Val Asn Ser Trp Cys Arg Arg Ala Arg Ala Lys 
    210                 215                 220                 


Ala Ala Ser Ala Gly Lys Lys Ala Ser Ser Ala Ala Ala Pro His Thr 
225                 230                 235                 240 


Val Ser Tyr Pro Asp Asn Leu Thr Tyr Arg Asp Leu Tyr Tyr Phe Leu 
                245                 250                 255     


Phe Ala Pro Thr Leu Cys Tyr Glu Leu Asn Phe Pro Arg Ser Pro Arg 
            260                 265                 270         


Ile Arg Lys Arg Phe Leu Leu Arg Arg Ile Leu Glu Met Leu Phe Phe 
        275                 280                 285             


Thr Gln Leu Gln Val Gly Leu Ile Gln Gln Trp Met Val Pro Thr Ile 
    290                 295                 300                 


Gln Asn Ser Met Lys Pro Phe Lys Asp Met Asp Tyr Ser Arg Ile Ile 
305                 310                 315                 320 


Glu Arg Leu Leu Lys Leu Ala Val Pro Asn His Leu Ile Trp Leu Ile 
                325                 330                 335     


Phe Phe Tyr Trp Leu Phe His Ser Cys Leu Asn Ala Val Ala Glu Leu 
            340                 345                 350         


Met Gln Phe Gly Asp Arg Glu Phe Tyr Arg Asp Trp Trp Asn Ser Glu 
        355                 360                 365             


Ser Val Thr Tyr Phe Trp Gln Asn Trp Asn Ile Pro Val His Lys Trp 
    370                 375                 380                 


Cys Ile Arg His Phe Tyr Lys Pro Met Leu Arg Arg Gly Ser Ser Lys 
385                 390                 395                 400 


Trp Met Ala Arg Thr Gly Val Phe Leu Ala Ser Ala Phe Phe His Glu 
                405                 410                 415     


Tyr Leu Val Ser Val Pro Leu Arg Met Phe Arg Leu Trp Ala Phe Thr 
            420                 425                 430         


Gly Met Met Ala Gln Ile Pro Leu Ala Trp Phe Val Gly Arg Phe Phe 
        435                 440                 445             


Gln Gly Asn Tyr Gly Asn Ala Ala Val Trp Leu Ser Leu Ile Ile Gly 
    450                 455                 460                 


Gln Pro Ile Ala Val Leu Met Tyr Val His Asp Tyr Tyr Val Leu Asn 
465                 470                 475                 480 


Tyr Glu Ala Pro Ala Ala Glu Ala 
                485             


<210>  3028
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGAT2__Homo_sapiens__NP_001240820

<400>  3028

Met Lys Thr Leu Ile Ala Ala Tyr Ser Gly Val Leu Arg Gly Glu Arg 
1               5                   10                  15      


Gln Ala Glu Ala Asp Arg Ser Gln Arg Ser His Gly Gly Pro Ala Leu 
            20                  25                  30          


Ser Arg Glu Gly Ser Gly Arg Trp Gly Val Ala Cys Ser Ala Ile Leu 
        35                  40                  45              


Met Tyr Ile Phe Cys Thr Asp Cys Trp Leu Ile Ala Val Leu Tyr Phe 
    50                  55                  60                  


Thr Trp Leu Val Phe Asp Trp Asn Thr Pro Lys Lys Gly Gly Arg Arg 
65                  70                  75                  80  


Ser Gln Trp Val Arg Asn Trp Ala Val Trp Arg Tyr Phe Arg Asp Tyr 
                85                  90                  95      


Phe Pro Ile Gln Leu Val Lys Thr His Asn Leu Leu Thr Thr Arg Asn 
            100                 105                 110         


Tyr Ile Phe Gly Tyr His Pro His Gly Ile Met Gly Leu Gly Ala Phe 
        115                 120                 125             


Cys Asn Phe Ser Thr Glu Ala Thr Glu Val Ser Lys Lys Phe Pro Gly 
    130                 135                 140                 


Ile Arg Pro Tyr Leu Ala Thr Leu Ala Gly Asn Phe Arg Met Pro Val 
145                 150                 155                 160 


Leu Arg Glu Tyr Leu Met Ser Gly Gly Ile Cys Pro Val Ser Arg Asp 
                165                 170                 175     


Thr Ile Asp Tyr Leu Leu Ser Lys Asn Gly Ser Gly Asn Ala Ile Ile 
            180                 185                 190         


Ile Val Val Gly Gly Ala Ala Glu Ser Leu Ser Ser Met Pro Gly Lys 
        195                 200                 205             


Asn Ala Val Thr Leu Arg Asn Arg Lys Gly Phe Val Lys Leu Ala Leu 
    210                 215                 220                 


Arg His Gly Ala Asp Leu Val Pro Ile Tyr Ser Phe Gly Glu Asn Glu 
225                 230                 235                 240 


Val Tyr Lys Gln Val Ile Phe Glu Glu Gly Ser Trp Gly Arg Trp Val 
                245                 250                 255     


Gln Lys Lys Phe Gln Lys Tyr Ile Gly Phe Ala Pro Cys Ile Phe His 
            260                 265                 270         


Gly Arg Gly Leu Phe Ser Ser Asp Thr Trp Gly Leu Val Pro Tyr Ser 
        275                 280                 285             


Lys Pro Ile Thr Thr Val Val Gly Glu Pro Ile Thr Ile Pro Lys Leu 
    290                 295                 300                 


Glu His Pro Thr Gln Gln Asp Ile Asp Leu Tyr His Thr Met Tyr Met 
305                 310                 315                 320 


Glu Ala Leu Val Lys Leu Phe Asp Lys His Lys Thr Lys Phe Gly Leu 
                325                 330                 335     


Pro Glu Thr Glu Val Leu Glu Val Asn 
            340                 345 


<210>  3029
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGCR2__Homo_sapiens__NP_001167004

<400>  3029

Met Val Pro Lys Ala Asp Ser Gly Ala Phe Leu Leu Leu Phe Leu Leu 
1               5                   10                  15      


Val Leu Thr Val Thr Glu Pro Leu Arg Pro Glu Val Thr Gly Glu Val 
            20                  25                  30          


Arg Pro His His Gly Lys Glu Ala Val Asp Pro Arg Gln Gly Arg Ala 
        35                  40                  45              


Arg Gly Gly Asp Pro Ser His Phe His Ala Val Asn Val Ala Gln Pro 
    50                  55                  60                  


Val Arg Phe Ser Ser Phe Leu Gly Lys Cys Pro Thr Gly Trp His His 
65                  70                  75                  80  


Tyr Glu Gly Thr Ala Ser Cys Tyr Arg Val Tyr Leu Ser Gly Glu Asn 
                85                  90                  95      


Tyr Trp Asp Ala Ala Gln Thr Cys Gln Arg Leu Asn Gly Ser Leu Ala 
            100                 105                 110         


Thr Phe Ser Thr Asp Gln Glu Leu Arg Phe Val Leu Ala Gln Glu Trp 
        115                 120                 125             


Asp Gln Pro Glu Arg Ser Phe Gly Trp Lys Asp Gln Arg Lys Leu Trp 
    130                 135                 140                 


Val Gly Tyr Gln Tyr Val Ile Thr Gly Arg Asn Arg Ser Leu Glu Gly 
145                 150                 155                 160 


Arg Trp Glu Val Ala Phe Lys Gly Ser Ser Glu Val Phe Leu Pro Pro 
                165                 170                 175     


Asp Pro Ile Phe Ala Ser Ala Met Ser Glu Asn Asp Asn Val Phe Cys 
            180                 185                 190         


Ala Gln Leu Gln Cys Phe His Phe Pro Thr Leu Arg His His Asp Leu 
        195                 200                 205             


His Ser Trp His Ala Glu Ser Cys Tyr Glu Lys Ser Ser Phe Leu Cys 
    210                 215                 220                 


Lys Arg Ser Gln Thr Cys Val Asp Ile Lys Asp Asn Val Val Asp Glu 
225                 230                 235                 240 


Gly Phe Tyr Phe Thr Pro Lys Gly Asp Asp Pro Cys Leu Ser Cys Thr 
                245                 250                 255     


Cys His Gly Gly Glu Pro Glu Met Cys Val Ala Ala Leu Cys Glu Arg 
            260                 265                 270         


Pro Gln Gly Cys Gln Gln Tyr Arg Lys Asp Pro Lys Glu Cys Cys Lys 
        275                 280                 285             


Phe Met Cys Leu Asp Pro Asp Gly Asn Ser Leu Phe Asp Ser Met Ala 
    290                 295                 300                 


Ser Gly Met Arg Leu Val Val Ser Cys Ile Ser Ser Phe Leu Ile Leu 
305                 310                 315                 320 


Ser Leu Leu Leu Phe Met Val His Arg Leu Arg Gln Arg Arg Arg Glu 
                325                 330                 335     


Arg Ile Glu Ser Leu Ile Gly Ala Asn Leu His His Phe Asn Leu Gly 
            340                 345                 350         


Arg Arg Ile Pro Gly Phe Asp Tyr Gly Pro Asp Gly Phe Gly Thr Gly 
        355                 360                 365             


Leu Thr Pro Leu His Leu Ser Asp Asp Gly Glu Gly Gly Thr Phe His 
    370                 375                 380                 


Phe His Asp Pro Pro Pro Pro Tyr Thr Ala Tyr Lys Tyr Pro Asp Ile 
385                 390                 395                 400 


Gly Gln Pro Asp Asp Pro Pro Pro Pro Tyr Glu Ala Ser Ile His Pro 
                405                 410                 415     


Asp Ser Val Phe Tyr Asp Pro Ala Asp Asp Asp Ala Phe Glu Pro Val 
            420                 425                 430         


Glu Val Ser Leu Pro Ala Pro Gly Asp Gly Gly Ser Glu Gly Ala Leu 
        435                 440                 445             


Leu Arg Arg Leu Glu Gln Pro Leu Pro Thr Ala Gly Ala Ser Leu Ala 
    450                 455                 460                 


Asp Leu Glu Asp Ser Ala Asp Ser Ser Ser Ala Leu Leu Val Pro Pro 
465                 470                 475                 480 


Asp Pro Ala Gln Ser Gly Ser Thr Pro Ala Ala Glu Ala Leu Pro Gly 
                485                 490                 495     


Gly Gly Arg His Ser Arg Ser Ser Leu Asn Thr Val Val 
            500                 505                 


<210>  3030
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGCR6L__Homo_sapiens__NP_150282

<400>  3030

Met Glu Arg Tyr Ala Ala Ala Leu Glu Glu Val Ala Asp Gly Ala Arg 
1               5                   10                  15      


Gln Gln Glu Arg His Tyr Gln Leu Leu Ser Ala Leu Gln Ser Leu Val 
            20                  25                  30          


Lys Glu Leu Pro Ser Ser Phe Gln Gln Arg Leu Ser Tyr Thr Thr Leu 
        35                  40                  45              


Ser Asp Leu Ala Leu Ala Leu Leu Asp Gly Thr Val Phe Glu Ile Val 
    50                  55                  60                  


Gln Gly Leu Leu Glu Ile Gln His Leu Thr Glu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Gln Arg Leu Arg Leu Gln Asn Glu His Arg Val Leu Arg Gln Ala Leu 
                85                  90                  95      


Arg Gln Lys His Gln Glu Ala Gln Gln Ala Cys Arg Pro His Asn Leu 
            100                 105                 110         


Pro Val Val Gln Ala Ala Gln Gln Arg Glu Leu Glu Ala Val Glu His 
        115                 120                 125             


Arg Ile Arg Glu Glu Gln Arg Ala Met Asp Gln Lys Ile Ile Leu Glu 
    130                 135                 140                 


Leu Asp Arg Lys Val Ala Asp Gln Gln Ser Thr Leu Glu Lys Ala Gly 
145                 150                 155                 160 


Val Ala Gly Phe Tyr Val Thr Thr Asn Pro Gln Glu Leu Met Leu Gln 
                165                 170                 175     


Met Asn Leu Leu Glu Leu Ile Arg Lys Leu Gln Gln Arg Gly Cys Arg 
            180                 185                 190         


Ala Gly Asn Ala Ala Leu Gly Leu Gly Gly Pro Trp Gln Ser Pro Ala 
        195                 200                 205             


Ala Gln Cys Asp Gln Lys Gly Ser Pro Val Pro Pro 
    210                 215                 220 


<210>  3031
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGCR8__Homo_sapiens__NP_001177255

<400>  3031

Met Glu Thr Asp Glu Ser Pro Ser Pro Leu Pro Cys Gly Pro Ala Gly 
1               5                   10                  15      


Glu Ala Val Met Glu Ser Arg Ala Arg Pro Phe Gln Ala Leu Pro Arg 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Gly Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Leu Pro Ala Glu 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Ala Glu Arg Asp Val 
    130                 135                 140                 


Arg Ala Glu Cys Gly Leu Leu Leu Ser Pro Val Ser Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asp Gly Val Gly Ile Gly Gly 
                165                 170                 175     


Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Ala Gly Gly Phe Thr Ala Lys Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Pro Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Thr Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Ser Ser 
        355                 360                 365             


Asp Leu Thr Pro Ser Gly Asp Val Ser Pro Val Lys Pro Leu Ser Arg 
    370                 375                 380                 


Ser Ala Glu Leu Glu Phe Pro Leu Asp Glu Pro Asp Ser Met Gly Ala 
385                 390                 395                 400 


Asp Pro Gly Pro Pro Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Pro Gly Ala Leu Gly Gln Val Lys Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Ser Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Ala Arg Ala Thr Leu Glu Ile Leu Ile 
    530                 535                 540                 


Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser Glu 
545                 550                 555                 560 


Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val Tyr 
                565                 570                 575     


Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu His 
            580                 585                 590         


Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys Phe 
        595                 600                 605             


Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala Cys 
    610                 615                 620                 


Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly Lys 
625                 630                 635                 640 


Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val Lys 
                645                 650                 655     


Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys Met 
            660                 665                 670         


Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln Tyr 
        675                 680                 685             


Ala Lys Lys Asn Lys Pro Asn Leu His Ile Leu Ser Lys Leu Gln Glu 
    690                 695                 700                 


Glu Met Lys Arg Leu Ala Glu Glu Arg Glu Glu Thr Arg Lys Lys Pro 
705                 710                 715                 720 


Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu Cys 
                725                 730                 735     


Thr Val Asp Val 
            740 


<210>  3032
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKA__Homo_sapiens__NP_958853

<400>  3032

Met Ala Lys Glu Arg Gly Leu Ile Ser Pro Ser Asp Phe Ala Gln Leu 
1               5                   10                  15      


Gln Lys Tyr Met Glu Tyr Ser Thr Lys Lys Val Ser Asp Val Leu Lys 
            20                  25                  30          


Leu Phe Glu Asp Gly Glu Met Ala Lys Tyr Val Gln Gly Asp Ala Ile 
        35                  40                  45              


Gly Tyr Glu Gly Phe Gln Gln Phe Leu Lys Ile Tyr Leu Glu Val Asp 
    50                  55                  60                  


Asn Val Pro Arg His Leu Ser Leu Ala Leu Phe Gln Ser Phe Glu Thr 
65                  70                  75                  80  


Gly His Cys Leu Asn Glu Thr Asn Val Thr Lys Asp Val Val Cys Leu 
                85                  90                  95      


Asn Asp Val Ser Cys Tyr Phe Ser Leu Leu Glu Gly Gly Arg Pro Glu 
            100                 105                 110         


Asp Lys Leu Glu Phe Thr Phe Lys Leu Tyr Asp Thr Asp Arg Asn Gly 
        115                 120                 125             


Ile Leu Asp Ser Ser Glu Val Asp Lys Ile Ile Leu Gln Met Met Arg 
    130                 135                 140                 


Val Ala Glu Tyr Leu Asp Trp Asp Val Ser Glu Leu Arg Pro Ile Leu 
145                 150                 155                 160 


Gln Glu Met Met Lys Glu Ile Asp Tyr Asp Gly Ser Gly Ser Val Ser 
                165                 170                 175     


Gln Ala Glu Trp Val Arg Ala Gly Ala Thr Thr Val Pro Leu Leu Val 
            180                 185                 190         


Leu Leu Gly Leu Glu Met Thr Leu Lys Asp Asp Gly Gln His Met Trp 
        195                 200                 205             


Arg Pro Lys Arg Phe Pro Arg Pro Val Tyr Cys Asn Leu Cys Glu Ser 
    210                 215                 220                 


Ser Ile Gly Leu Gly Lys Gln Gly Leu Ser Cys Asn Leu Cys Lys Tyr 
225                 230                 235                 240 


Thr Val His Asp Gln Cys Ala Met Lys Ala Leu Pro Cys Glu Val Ser 
                245                 250                 255     


Thr Tyr Ala Lys Ser Arg Lys Asp Ile Gly Val Gln Ser His Val Trp 
            260                 265                 270         


Val Arg Gly Gly Cys Glu Ser Gly Arg Cys Asp Arg Cys Gln Lys Lys 
        275                 280                 285             


Ile Arg Ile Tyr His Ser Leu Thr Gly Leu His Cys Val Trp Cys His 
    290                 295                 300                 


Leu Glu Ile His Asp Asp Cys Leu Gln Ala Val Gly His Glu Cys Asp 
305                 310                 315                 320 


Cys Gly Leu Leu Arg Asp His Ile Leu Pro Pro Ser Ser Ile Tyr Pro 
                325                 330                 335     


Ser Val Leu Ala Ser Gly Pro Asp Arg Lys Asn Ser Lys Thr Ser Gln 
            340                 345                 350         


Lys Thr Met Asp Asp Leu Asn Leu Ser Thr Ser Glu Ala Leu Arg Ile 
        355                 360                 365             


Asp Pro Val Pro Asn Thr His Pro Leu Leu Val Phe Val Asn Pro Lys 
    370                 375                 380                 


Ser Gly Gly Lys Gln Gly Gln Arg Val Leu Trp Lys Phe Gln Tyr Ile 
385                 390                 395                 400 


Leu Asn Pro Arg Gln Val Phe Asn Leu Leu Lys Asp Gly Pro Glu Ile 
                405                 410                 415     


Gly Leu Arg Leu Phe Lys Asp Val Pro Asp Ser Arg Ile Leu Val Cys 
            420                 425                 430         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Glu Thr Ile Asp Lys Ala 
        435                 440                 445             


Asn Leu Pro Val Leu Pro Pro Val Ala Val Leu Pro Leu Gly Thr Gly 
    450                 455                 460                 


Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gln 
465                 470                 475                 480 


Asn Leu Ala Lys Ile Leu Lys Asp Leu Glu Met Ser Lys Val Val His 
                485                 490                 495     


Met Asp Arg Trp Ser Val Glu Val Ile Pro Gln Gln Thr Glu Glu Lys 
            500                 505                 510         


Ser Asp Pro Val Pro Phe Gln Ile Ile Asn Asn Tyr Phe Ser Ile Gly 
        515                 520                 525             


Val Asp Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys Tyr 
    530                 535                 540                 


Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu 
545                 550                 555                 560 


Phe Ala Thr Ser Glu Ser Ile Phe Ser Thr Cys Lys Lys Leu Glu Glu 
                565                 570                 575     


Ser Leu Thr Val Glu Ile Cys Gly Lys Pro Leu Asp Leu Ser Asn Leu 
            580                 585                 590         


Ser Leu Glu Gly Ile Ala Val Leu Asn Ile Pro Ser Met His Gly Gly 
        595                 600                 605             


Ser Asn Leu Trp Gly Asp Thr Arg Arg Pro His Gly Asp Ile Tyr Gly 
    610                 615                 620                 


Ile Asn Gln Ala Leu Gly Ala Thr Ala Lys Val Ile Thr Asp Pro Asp 
625                 630                 635                 640 


Ile Leu Lys Thr Cys Val Pro Asp Leu Ser Asp Lys Arg Leu Glu Val 
                645                 650                 655     


Val Gly Leu Glu Gly Ala Ile Glu Met Gly Gln Ile Tyr Thr Lys Leu 
            660                 665                 670         


Lys Asn Ala Gly Arg Arg Leu Ala Lys Cys Ser Glu Ile Thr Phe His 
        675                 680                 685             


Thr Thr Lys Thr Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln 
    690                 695                 700                 


Thr Pro Cys Thr Ile Lys Ile Thr His Lys Asn Gln Met Pro Met Leu 
705                 710                 715                 720 


Met Gly Pro Pro Pro Arg Ser Thr Asn Phe Phe Gly Phe Leu Ser 
                725                 730                 735 


<210>  3033
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKB__Homo_sapiens__NP_004071

<400>  3033

Met Thr Asn Gln Glu Lys Trp Ala His Leu Ser Pro Ser Glu Phe Ser 
1               5                   10                  15      


Gln Leu Gln Lys Tyr Ala Glu Tyr Ser Thr Lys Lys Leu Lys Asp Val 
            20                  25                  30          


Leu Glu Glu Phe His Gly Asn Gly Val Leu Ala Lys Tyr Asn Pro Glu 
        35                  40                  45              


Gly Lys Gln Asp Ile Leu Asn Gln Thr Ile Asp Phe Glu Gly Phe Lys 
    50                  55                  60                  


Leu Phe Met Lys Thr Phe Leu Glu Ala Glu Leu Pro Asp Asp Phe Thr 
65                  70                  75                  80  


Ala His Leu Phe Met Ser Phe Ser Asn Lys Phe Pro His Ser Ser Pro 
                85                  90                  95      


Met Val Lys Ser Lys Pro Ala Leu Leu Ser Gly Gly Leu Arg Met Asn 
            100                 105                 110         


Lys Gly Ala Ile Thr Pro Pro Arg Thr Thr Ser Pro Ala Asn Thr Cys 
        115                 120                 125             


Ser Pro Glu Val Ile His Leu Lys Asp Ile Val Cys Tyr Leu Ser Leu 
    130                 135                 140                 


Leu Glu Arg Gly Arg Pro Glu Asp Lys Leu Glu Phe Met Phe Arg Leu 
145                 150                 155                 160 


Tyr Asp Thr Asp Gly Asn Gly Phe Leu Asp Ser Ser Glu Leu Glu Asn 
                165                 170                 175     


Ile Ile Ser Gln Met Met His Val Ala Glu Tyr Leu Glu Trp Asp Val 
            180                 185                 190         


Thr Glu Leu Asn Pro Ile Leu His Glu Met Met Glu Glu Ile Asp Tyr 
        195                 200                 205             


Asp His Asp Gly Thr Val Ser Leu Glu Glu Trp Ile Gln Gly Gly Met 
    210                 215                 220                 


Thr Thr Ile Pro Leu Leu Val Leu Leu Gly Leu Glu Asn Asn Val Lys 
225                 230                 235                 240 


Asp Asp Gly Gln His Val Trp Arg Leu Lys His Phe Asn Lys Pro Ala 
                245                 250                 255     


Tyr Cys Asn Leu Cys Leu Asn Met Leu Ile Gly Val Gly Lys Gln Gly 
            260                 265                 270         


Leu Cys Cys Ser Phe Cys Lys Tyr Thr Val His Glu Arg Cys Val Ala 
        275                 280                 285             


Arg Ala Pro Pro Ser Cys Ile Lys Thr Tyr Val Lys Ser Lys Arg Asn 
    290                 295                 300                 


Thr Asp Val Met His His Tyr Trp Val Glu Gly Asn Cys Pro Thr Lys 
305                 310                 315                 320 


Cys Asp Lys Cys His Lys Thr Val Lys Cys Tyr Gln Gly Leu Thr Gly 
                325                 330                 335     


Leu His Cys Val Trp Cys Gln Ile Thr Leu His Asn Lys Cys Ala Ser 
            340                 345                 350         


His Leu Lys Pro Glu Cys Asp Cys Gly Pro Leu Lys Asp His Ile Leu 
        355                 360                 365             


Pro Pro Thr Thr Ile Cys Pro Val Val Leu Gln Thr Leu Pro Thr Ser 
    370                 375                 380                 


Gly Val Ser Val Pro Glu Glu Arg Gln Ser Thr Val Lys Lys Glu Lys 
385                 390                 395                 400 


Ser Gly Ser Gln Gln Pro Asn Lys Val Ile Asp Lys Asn Lys Met Gln 
                405                 410                 415     


Arg Ala Asn Ser Val Thr Val Asp Gly Gln Gly Leu Gln Val Thr Pro 
            420                 425                 430         


Val Pro Gly Thr His Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly 
        435                 440                 445             


Gly Lys Gln Gly Glu Arg Ile Tyr Arg Lys Phe Gln Tyr Leu Leu Asn 
    450                 455                 460                 


Pro Arg Gln Val Tyr Ser Leu Ser Gly Asn Gly Pro Met Pro Gly Leu 
465                 470                 475                 480 


Asn Phe Phe Arg Asp Val Pro Asp Phe Arg Val Leu Ala Cys Gly Gly 
                485                 490                 495     


Asp Gly Thr Val Gly Trp Val Leu Asp Cys Ile Glu Lys Ala Asn Val 
            500                 505                 510         


Gly Lys His Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp 
        515                 520                 525             


Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Glu Asn Leu 
    530                 535                 540                 


Met Lys Ile Leu Lys Asp Ile Glu Asn Ser Thr Glu Ile Met Leu Asp 
545                 550                 555                 560 


Arg Trp Lys Phe Glu Val Ile Pro Asn Asp Lys Asp Glu Lys Gly Asp 
                565                 570                 575     


Pro Val Pro Tyr Ser Ile Ile Asn Asn Tyr Phe Ser Ile Gly Val Asp 
            580                 585                 590         


Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys His Pro Glu 
        595                 600                 605             


Lys Phe Asn Ser Arg Met Lys Asn Lys Phe Trp Tyr Phe Glu Phe Gly 
    610                 615                 620                 


Thr Ser Glu Thr Phe Ser Ala Thr Cys Lys Lys Leu His Glu Ser Val 
625                 630                 635                 640 


Glu Ile Glu Cys Asp Gly Val Gln Ile Asp Leu Ile Asn Ile Ser Leu 
                645                 650                 655     


Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser Met His Gly Gly Ser Asn 
            660                 665                 670         


Leu Trp Gly Glu Ser Lys Lys Arg Arg Ser His Arg Arg Ile Glu Lys 
        675                 680                 685             


Lys Gly Ser Asp Lys Arg Thr Thr Val Thr Asp Ala Lys Glu Leu Lys 
    690                 695                 700                 


Phe Ala Ser Gln Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu 
705                 710                 715                 720 


Glu Gly Ala Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala 
                725                 730                 735     


Gly Arg Arg Leu Ala Gln Cys Ser Cys Val Val Ile Arg Thr Ser Lys 
            740                 745                 750         


Ser Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln Thr Pro Cys 
        755                 760                 765             


Thr Ile Lys Ile Thr His Lys Asn Gln Ala Pro Met Leu Met Gly Pro 
    770                 775                 780                 


Pro Pro Lys Thr Gly Leu Phe Cys Ser Leu Val Lys Arg Thr Arg Asn 
785                 790                 795                 800 


Arg Ser Lys Glu 
                


<210>  3034
<211>  1170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKD__Homo_sapiens__NP_003639

<400>  3034

Met Asn Met Phe Leu Tyr Phe Gln Thr Ile Ile Lys Glu Gly Met Leu 
1               5                   10                  15      


Thr Lys Gln Asn Asn Ser Phe Gln Arg Ser Lys Arg Arg Tyr Phe Lys 
            20                  25                  30          


Leu Arg Gly Arg Thr Leu Tyr Tyr Ala Lys Thr Ala Lys Ser Ile Ile 
        35                  40                  45              


Phe Asp Glu Val Asp Leu Thr Asp Ala Ser Val Ala Glu Ser Ser Thr 
    50                  55                  60                  


Lys Asn Val Asn Asn Ser Phe Thr Val Ile Thr Pro Cys Arg Lys Leu 
65                  70                  75                  80  


Ile Leu Cys Ala Asp Asn Arg Lys Glu Met Glu Asp Trp Ile Ala Ala 
                85                  90                  95      


Leu Lys Thr Val Gln Asn Arg Glu His Phe Glu Pro Thr Gln Tyr Ser 
            100                 105                 110         


Met Asp His Phe Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala 
        115                 120                 125             


Arg Pro Thr Tyr Cys Asn Val Cys Arg Glu Ala Leu Ser Gly Val Thr 
    130                 135                 140                 


Ser His Gly Leu Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg 
145                 150                 155                 160 


Cys Ala Val Arg Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser 
                165                 170                 175     


Ile Gly Lys Asp Ile Ile Glu Asp Ala Asp Gly Ile Ala Met Pro His 
            180                 185                 190         


Gln Trp Leu Glu Gly Asn Leu Pro Val Ser Ala Lys Cys Thr Val Cys 
        195                 200                 205             


Asp Lys Thr Cys Gly Ser Val Leu Arg Leu Gln Asp Trp Arg Cys Leu 
    210                 215                 220                 


Trp Cys Lys Ala Met Val His Thr Ser Cys Lys Glu Ser Leu Leu Thr 
225                 230                 235                 240 


Lys Cys Pro Leu Gly Leu Cys Lys Val Ser Val Ile Pro Pro Thr Ala 
                245                 250                 255     


Leu Asn Ser Ile Asp Ser Asp Gly Phe Trp Lys Ala Ser Cys Pro Pro 
            260                 265                 270         


Ser Cys Thr Ser Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp 
        275                 280                 285             


Asn Gln Gly Val Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro 
    290                 295                 300                 


Ala Gln Val Phe Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg 
305                 310                 315                 320 


Leu Phe Gln Lys Phe Asp Thr Phe Arg Ile Leu Val Cys Gly Gly Asp 
                325                 330                 335     


Gly Ser Val Gly Trp Val Leu Ser Glu Ile Asp Ser Leu Asn Leu His 
            340                 345                 350         


Lys Gln Cys Gln Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu 
        355                 360                 365             


Ala Arg Val Leu Gly Trp Gly Ser Ala Cys Asp Asp Asp Thr Gln Leu 
    370                 375                 380                 


Pro Gln Ile Leu Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp 
385                 390                 395                 400 


Arg Trp Ser Val Met Ala Tyr Glu Ala Lys Leu Pro Arg Gln Ala Ser 
                405                 410                 415     


Ser Ser Thr Val Thr Glu Asp Phe Ser Glu Asp Ser Glu Val Gln Gln 
            420                 425                 430         


Ile Leu Phe Tyr Glu Asp Ser Val Ala Ala His Leu Ser Lys Ile Leu 
        435                 440                 445             


Thr Ser Asp Gln His Ser Val Val Ile Ser Ser Ala Lys Val Leu Cys 
    450                 455                 460                 


Glu Thr Val Lys Asp Phe Val Ala Arg Val Gly Lys Ala Tyr Glu Lys 
465                 470                 475                 480 


Thr Thr Glu Ser Ser Glu Glu Ser Glu Val Met Ala Lys Lys Cys Ser 
                485                 490                 495     


Val Leu Lys Glu Lys Leu Asp Ser Leu Leu Lys Thr Leu Asp Asp Glu 
            500                 505                 510         


Ser Gln Ala Ser Ser Ser Leu Pro Asn Pro Pro Pro Thr Ile Ala Glu 
        515                 520                 525             


Glu Ala Glu Asp Gly Asp Gly Ser Gly Ser Ile Cys Gly Ser Thr Gly 
    530                 535                 540                 


Asp Arg Leu Val Ala Ser Ala Cys Pro Ala Arg Pro Gln Ile Phe Arg 
545                 550                 555                 560 


Pro Arg Glu Gln Leu Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Ile 
                565                 570                 575     


Arg Gln Ile Ile Glu His Thr Glu Lys Ala Val Asp Glu Gln Asn Ala 
            580                 585                 590         


Gln Thr Gln Glu Gln Glu Gly Phe Val Leu Gly Leu Ser Glu Ser Glu 
        595                 600                 605             


Glu Lys Met Asp His Arg Val Cys Pro Pro Leu Ser His Ser Glu Ser 
    610                 615                 620                 


Phe Gly Val Pro Lys Gly Arg Ser Gln Arg Lys Val Ser Lys Ser Pro 
625                 630                 635                 640 


Cys Glu Lys Leu Ile Ser Lys Gly Ser Leu Ser Leu Gly Ser Ser Ala 
                645                 650                 655     


Ser Leu Pro Pro Gln Pro Gly Ser Arg Asp Gly Leu Pro Ala Leu Asn 
            660                 665                 670         


Thr Lys Ile Leu Tyr Pro Asn Val Arg Ala Gly Met Ser Gly Ser Leu 
        675                 680                 685             


Pro Gly Gly Ser Val Ile Ser Arg Leu Leu Ile Asn Ala Asp Pro Phe 
    690                 695                 700                 


Asn Ser Glu Pro Glu Thr Leu Glu Tyr Tyr Thr Glu Lys Cys Val Met 
705                 710                 715                 720 


Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe 
                725                 730                 735     


Asn Asn Lys Arg Asp Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys 
            740                 745                 750         


Asn Met Met Trp Tyr Gly Val Leu Gly Thr Lys Glu Leu Leu His Arg 
        755                 760                 765             


Thr Tyr Lys Asn Leu Glu Gln Lys Val Leu Leu Glu Cys Asp Gly Arg 
    770                 775                 780                 


Pro Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro 
785                 790                 795                 800 


Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp 
                805                 810                 815     


Thr Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala 
            820                 825                 830         


Val Phe Gly Ser Met Gln Met Ala Val Ser Arg Val Ile Arg Leu Gln 
        835                 840                 845             


His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Ser Ile Leu Gly 
    850                 855                 860                 


Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro 
865                 870                 875                 880 


Pro Gly Tyr Ile Arg Ile Val His Lys Asn Arg Ala Gln Thr Leu Thr 
                885                 890                 895     


Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln 
            900                 905                 910         


Lys Cys Glu Leu Pro Arg Pro Pro Ser Cys Ser Leu His Pro Glu Met 
        915                 920                 925             


Leu Ser Glu Glu Glu Ala Thr Gln Met Asp Gln Phe Gly Gln Ala Ala 
    930                 935                 940                 


Gly Val Leu Ile His Ser Ile Arg Glu Ile Ala Gln Ser His Arg Asp 
945                 950                 955                 960 


Met Glu Gln Glu Leu Ala His Ala Val Asn Ala Ser Ser Lys Ser Met 
                965                 970                 975     


Asp Arg Val Tyr Gly Lys Pro Arg Thr Thr Glu Gly Leu Asn Cys Ser 
            980                 985                 990         


Phe Val Leu Glu Met Val Asn Asn  Phe Arg Ala Leu Arg  Ser Glu Thr 
        995                 1000                 1005             


Glu Leu  Leu Leu Ser Gly Lys  Met Ala Leu Gln Leu  Asp Pro Pro 
    1010                 1015                 1020             


Gln Lys  Glu Gln Leu Gly Ser  Ala Leu Ala Glu Met  Asp Arg Gln 
    1025                 1030                 1035             


Leu Arg  Arg Leu Ala Asp Thr  Pro Trp Leu Cys Gln  Ser Ala Glu 
    1040                 1045                 1050             


Pro Gly  Asp Glu Glu Ser Val  Met Leu Asp Leu Ala  Lys Arg Ser 
    1055                 1060                 1065             


Arg Ser  Gly Lys Phe Arg Leu  Val Thr Lys Phe Lys  Lys Glu Lys 
    1070                 1075                 1080             


Asn Asn  Lys Asn Lys Glu Ala  His Ser Ser Leu Gly  Ala Pro Val 
    1085                 1090                 1095             


His Leu  Trp Gly Thr Glu Glu  Val Ala Ala Trp Leu  Glu His Leu 
    1100                 1105                 1110             


Ser Leu  Cys Glu Tyr Lys Asp  Ile Phe Thr Arg His  Asp Ile Arg 
    1115                 1120                 1125             


Gly Ser  Glu Leu Leu His Leu  Glu Arg Arg Asp Leu  Lys Asp Leu 
    1130                 1135                 1140             


Gly Val  Thr Lys Val Gly His  Met Lys Arg Ile Leu  Cys Gly Ile 
    1145                 1150                 1155             


Lys Glu  Leu Ser Arg Ser Ala  Pro Ala Val Glu Ala  
    1160                 1165                 1170 


<210>  3035
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKE__Homo_sapiens__NP_003638

<400>  3035

Met Glu Ala Glu Arg Arg Pro Ala Pro Gly Ser Pro Ser Glu Gly Leu 
1               5                   10                  15      


Phe Ala Asp Gly His Leu Ile Leu Trp Thr Leu Cys Ser Val Leu Leu 
            20                  25                  30          


Pro Val Phe Ile Thr Phe Trp Cys Ser Leu Gln Arg Ser Arg Arg Gln 
        35                  40                  45              


Leu His Arg Arg Asp Ile Phe Arg Lys Ser Lys His Gly Trp Arg Asp 
    50                  55                  60                  


Thr Asp Leu Phe Ser Gln Pro Thr Tyr Cys Cys Val Cys Ala Gln His 
65                  70                  75                  80  


Ile Leu Gln Gly Ala Phe Cys Asp Cys Cys Gly Leu Arg Val Asp Glu 
                85                  90                  95      


Gly Cys Leu Arg Lys Ala Asp Lys Arg Phe Gln Cys Lys Glu Ile Met 
            100                 105                 110         


Leu Lys Asn Asp Thr Lys Val Leu Asp Ala Met Pro His His Trp Ile 
        115                 120                 125             


Arg Gly Asn Val Pro Leu Cys Ser Tyr Cys Met Val Cys Lys Gln Gln 
    130                 135                 140                 


Cys Gly Cys Gln Pro Lys Leu Cys Asp Tyr Arg Cys Ile Trp Cys Gln 
145                 150                 155                 160 


Lys Thr Val His Asp Glu Cys Met Lys Asn Ser Leu Lys Asn Glu Lys 
                165                 170                 175     


Cys Asp Phe Gly Glu Phe Lys Asn Leu Ile Ile Pro Pro Ser Tyr Leu 
            180                 185                 190         


Thr Ser Ile Asn Gln Met Arg Lys Asp Lys Lys Thr Asp Tyr Glu Val 
        195                 200                 205             


Leu Ala Ser Lys Leu Gly Lys Gln Trp Thr Pro Leu Ile Ile Leu Ala 
    210                 215                 220                 


Asn Ser Arg Ser Gly Thr Asn Met Gly Glu Gly Leu Leu Gly Glu Phe 
225                 230                 235                 240 


Arg Ile Leu Leu Asn Pro Val Gln Val Phe Asp Val Thr Lys Thr Pro 
                245                 250                 255     


Pro Ile Lys Ala Leu Gln Leu Cys Thr Leu Leu Pro Tyr Tyr Ser Ala 
            260                 265                 270         


Arg Val Leu Val Cys Gly Gly Asp Gly Thr Val Gly Trp Val Leu Asp 
        275                 280                 285             


Ala Val Asp Asp Met Lys Ile Lys Gly Gln Glu Lys Tyr Ile Pro Gln 
    290                 295                 300                 


Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ser Asn Thr Leu 
305                 310                 315                 320 


Gly Trp Gly Thr Gly Tyr Ala Gly Glu Ile Pro Val Ala Gln Val Leu 
                325                 330                 335     


Arg Asn Val Met Glu Ala Asp Gly Ile Lys Leu Asp Arg Trp Lys Val 
            340                 345                 350         


Gln Val Thr Asn Lys Gly Tyr Tyr Asn Leu Arg Lys Pro Lys Glu Phe 
        355                 360                 365             


Thr Met Asn Asn Tyr Phe Ser Val Gly Pro Asp Ala Leu Met Ala Leu 
    370                 375                 380                 


Asn Phe His Ala His Arg Glu Lys Ala Pro Ser Leu Phe Ser Ser Arg 
385                 390                 395                 400 


Ile Leu Asn Lys Ala Val Tyr Leu Phe Tyr Gly Thr Lys Asp Cys Leu 
                405                 410                 415     


Val Gln Glu Cys Lys Asp Leu Asn Lys Lys Val Glu Leu Glu Leu Asp 
            420                 425                 430         


Gly Glu Arg Val Ala Leu Pro Ser Leu Glu Gly Ile Ile Val Leu Asn 
        435                 440                 445             


Ile Gly Tyr Trp Gly Gly Gly Cys Arg Leu Trp Glu Gly Met Gly Asp 
    450                 455                 460                 


Glu Thr Tyr Pro Leu Ala Arg His Asp Asp Gly Leu Leu Glu Val Val 
465                 470                 475                 480 


Gly Val Tyr Gly Ser Phe His Cys Ala Gln Ile Gln Val Lys Leu Ala 
                485                 490                 495     


Asn Pro Phe Arg Ile Gly Gln Ala His Thr Val Arg Leu Ile Leu Lys 
            500                 505                 510         


Cys Ser Met Met Pro Met Gln Val Asp Gly Glu Pro Trp Ala Gln Gly 
        515                 520                 525             


Pro Cys Thr Val Thr Ile Thr His Lys Thr His Ala Met Met Leu Tyr 
    530                 535                 540                 


Phe Ser Gly Glu Gln Thr Asp Asp Asp Ile Ser Ser Thr Ser Asp Gln 
545                 550                 555                 560 


Glu Asp Ile Lys Ala Thr Glu 
                565         


<210>  3036
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKG__Homo_sapiens__NP_001074213

<400>  3036

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15      


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30          


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45              


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60                  


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80  


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95      


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110         


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125             


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140                 


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160 


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175     


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190         


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205             


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220                 


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240 


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255     


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270         


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285             


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300                 


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320 


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335     


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350         


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365             


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380                 


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400 


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415     


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430         


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445             


Glu Arg Leu Asn Phe Phe Arg Asp Thr Pro Asp Phe Arg Val Leu Ala 
    450                 455                 460                 


Cys Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Asp Cys Ile Asp Lys 
465                 470                 475                 480 


Ala Asn Phe Ala Lys His Pro Pro Val Ala Val Leu Pro Leu Gly Thr 
                485                 490                 495     


Gly Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly 
            500                 505                 510         


Gly Ser Leu Thr Lys Ile Leu Lys Asp Ile Glu Gln Ser Pro Leu Val 
        515                 520                 525             


Met Leu Asp Arg Trp His Leu Glu Val Ile Pro Arg Glu Glu Val Glu 
    530                 535                 540                 


Asn Gly Asp Gln Val Pro Tyr Ser Ile Met Asn Asn Tyr Phe Ser Ile 
545                 550                 555                 560 


Gly Val Asp Ala Ser Ile Ala His Arg Phe His Val Met Arg Glu Lys 
                565                 570                 575     


His Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe 
            580                 585                 590         


Glu Phe Gly Thr Ser Glu Thr Phe Ala Ala Thr Cys Lys Lys Leu His 
        595                 600                 605             


Asp His Ile Glu Leu Glu Cys Asp Gly Val Gly Val Asp Leu Ser Asn 
    610                 615                 620                 


Ile Phe Leu Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser Met Tyr Gly 
625                 630                 635                 640 


Gly Thr Asn Leu Trp Gly Glu Asn Lys Lys Asn Arg Ala Val Ile Arg 
                645                 650                 655     


Glu Ser Arg Lys Gly Val Thr Asp Pro Lys Glu Leu Lys Phe Cys Val 
            660                 665                 670         


Gln Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu Glu Gly Ala 
        675                 680                 685             


Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala Gly Arg Arg 
    690                 695                 700                 


Leu Ala Gln Cys Ala Ser Val Thr Ile Arg Thr Asn Lys Leu Leu Pro 
705                 710                 715                 720 


Met Gln Val Asp Gly Glu Pro Trp Met Gln Pro Cys Cys Thr Ile Lys 
                725                 730                 735     


Ile Thr His Lys Asn Gln Ala Pro Met Met Met Gly Pro Pro Gln Lys 
            740                 745                 750         


Ser Ser Phe Phe Ser Leu Arg Arg Lys Ser Arg Ser Lys Asp 
        755                 760                 765     


<210>  3037
<211>  1164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKH__Homo_sapiens__NP_001191433

<400>  3037

Met Ala Gly Ala Gly Gly Gln His His Pro Pro Gly Ala Ala Gly Gly 
1               5                   10                  15      


Ala Ala Ala Gly Ala Gly Ala Ala Val Thr Ser Ala Ala Ala Ser Ala 
            20                  25                  30          


Gly Pro Gly Glu Asp Ser Ser Asp Ser Glu Ala Glu Gln Glu Gly Pro 
        35                  40                  45              


Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln Ile Arg Thr Lys 
    50                  55                  60                  


Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Ser Phe Gln 
65                  70                  75                  80  


Arg Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr 
                85                  90                  95      


Ala Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp 
            100                 105                 110         


Ala Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr 
        115                 120                 125             


Ile Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys 
    130                 135                 140                 


Glu Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His 
                165                 170                 175     


Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys 
            180                 185                 190         


Arg Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val 
        195                 200                 205             


Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn 
    210                 215                 220                 


Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp 
225                 230                 235                 240 


Glu Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro 
                245                 250                 255     


Val Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu 
            260                 265                 270         


Arg Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr 
        275                 280                 285             


Ala Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys 
    290                 295                 300                 


Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly 
305                 310                 315                 320 


Phe Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe 
                325                 330                 335     


Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg 
            340                 345                 350         


Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly 
        355                 360                 365             


Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg 
    370                 375                 380                 


Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu 
385                 390                 395                 400 


Ile Asp Lys Leu Asn Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro 
                405                 410                 415     


Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser 
            420                 425                 430         


Tyr Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg 
        435                 440                 445             


Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu 
    450                 455                 460                 


Lys Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser 
465                 470                 475                 480 


Glu Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu 
                485                 490                 495     


Thr Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser Ala 
            500                 505                 510         


Lys Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys 
        515                 520                 525             


Thr Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala 
    530                 535                 540                 


Ser Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala 
545                 550                 555                 560 


Leu His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro 
                565                 570                 575     


Leu Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu 
            580                 585                 590         


Gly Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser 
        595                 600                 605             


Gln Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu 
    610                 615                 620                 


Lys Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp 
625                 630                 635                 640 


Asp Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr 
                645                 650                 655     


Asp Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Gly 
            660                 665                 670         


Ala Lys Glu Ser Ile Thr Val Lys Thr Ala Pro Arg Ser Pro Asp Ala 
        675                 680                 685             


Arg Ala Ser Tyr Gly His Ser Gln Thr Asp Ser Val Pro Gly Pro Ala 
    690                 695                 700                 


Val Ala Ala Ser Lys Glu Asn Leu Pro Val Leu Asn Thr Arg Ile Ile 
705                 710                 715                 720 


Cys Pro Gly Leu Arg Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser Ser 
                725                 730                 735     


Ile Ile Asn Lys Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr 
            740                 745                 750         


Pro Phe Ile Asp Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys 
        755                 760                 765             


Cys Val Met Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser 
    770                 775                 780                 


Leu Glu Phe Asn Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser 
785                 790                 795                 800 


Arg Thr Lys Asn Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu 
                805                 810                 815     


Leu Gln Arg Ser Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys 
            820                 825                 830         


Asp Gly Gln Tyr Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu 
        835                 840                 845             


Asn Ile Pro Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys 
    850                 855                 860                 


Glu Asp Asp Ile Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu 
865                 870                 875                 880 


Val Val Ala Ile Phe Asp Ser Met Gln Met Ala Val Ser Arg Val Ile 
                885                 890                 895     


Lys Leu Gln His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr 
            900                 905                 910         


Ile Phe Gly Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp 
        915                 920                 925             


Val Gln Pro Pro Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln 
    930                 935                 940                 


Met Leu Thr Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu 
945                 950                 955                 960 


Asp Lys Gln Lys Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu 
                965                 970                 975     


Tyr Ile His His Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met 
            980                 985                 990         


Gln Leu Cys Ser Gln Ala Ala Glu  Glu Leu Ile Thr Arg  Ile Cys Asp 
        995                 1000                 1005             


Ala Ala  Thr Ile His Cys Leu  Leu Glu Gln Glu Leu  Ala His Ala 
    1010                 1015                 1020             


Val Asn  Ala Cys Ser His Ala  Leu Asn Lys Ala Asn  Pro Arg Cys 
    1025                 1030                 1035             


Pro Glu  Ser Leu Thr Arg Asp  Thr Ala Thr Glu Ile  Ala Ile Asn 
    1040                 1045                 1050             


Val Lys  Ala Leu Tyr Asn Glu  Thr Glu Ser Leu Leu  Val Gly Arg 
    1055                 1060                 1065             


Val Pro  Leu Gln Leu Glu Ser  Pro His Glu Glu Arg  Val Ser Asn 
    1070                 1075                 1080             


Ala Leu  His Ser Val Glu Val  Glu Leu Gln Lys Leu  Thr Glu Ile 
    1085                 1090                 1095             


Pro Trp  Leu Tyr Tyr Ile Leu  His Pro Asn Glu Asp  Glu Glu Pro 
    1100                 1105                 1110             


Pro Met  Asp Cys Thr Lys Arg  Asn Asn Arg Ser Thr  Val Phe Arg 
    1115                 1120                 1125             


Ile Val  Pro Lys Phe Lys Lys  Glu Lys Val Gln Lys  Gln Lys Thr 
    1130                 1135                 1140             


Ser Ser  Gln Pro Gly Ser Gly  Asp Thr Glu Ser Gly  Ser Cys Glu 
    1145                 1150                 1155             


Ala Asn  Ser Pro Gly Asn 
    1160                 


<210>  3038
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKI__Homo_sapiens__NP_004708

<400>  3038

Met Asp Ala Ala Gly Arg Gly Cys His Leu Leu Pro Leu Pro Ala Ala 
1               5                   10                  15      


Arg Gly Pro Ala Arg Ala Pro Ala Ala Ala Ala Ala Ala Ala Ala Ser 
            20                  25                  30          


Pro Pro Gly Pro Cys Ser Gly Ala Ala Cys Ala Pro Ser Ala Ala Ala 
        35                  40                  45              


Gly Ala Gly Ala Met Asn Pro Ser Ser Ser Ala Gly Glu Glu Lys Gly 
    50                  55                  60                  


Ala Thr Gly Gly Ser Ser Ser Ser Gly Ser Gly Ala Gly Ser Cys Cys 
65                  70                  75                  80  


Leu Gly Ala Glu Gly Gly Ala Asp Pro Arg Gly Ala Gly Ser Ala Ala 
                85                  90                  95      


Ala Ala Gly Ala Ala Ala Leu Asp Glu Pro Ala Ala Ala Gly Gln Lys 
            100                 105                 110         


Glu Lys Asp Glu Ala Leu Glu Glu Lys Leu Arg Asn Leu Thr Phe Arg 
        115                 120                 125             


Lys Gln Val Ser Tyr Arg Lys Ala Ile Ser Arg Ala Gly Leu Gln His 
    130                 135                 140                 


Leu Ala Pro Ala His Pro Leu Ser Leu Pro Val Ala Asn Gly Pro Ala 
145                 150                 155                 160 


Lys Glu Pro Arg Ala Thr Leu Asp Trp Ser Glu Asn Ala Val Asn Gly 
                165                 170                 175     


Glu His Leu Trp Leu Glu Thr Asn Val Ser Gly Asp Leu Cys Tyr Leu 
            180                 185                 190         


Gly Glu Glu Asn Cys Gln Val Arg Phe Ala Lys Ser Ala Leu Arg Arg 
        195                 200                 205             


Lys Cys Ala Val Cys Lys Ile Val Val His Thr Ala Cys Ile Glu Gln 
    210                 215                 220                 


Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Thr Phe Arg Glu Gly Gly 
225                 230                 235                 240 


Ser Arg Ser Pro Arg Glu Asn Phe Val Arg His His Trp Val His Arg 
                245                 250                 255     


Arg Arg Gln Glu Gly Lys Cys Lys Gln Cys Gly Lys Gly Phe Gln Gln 
            260                 265                 270         


Lys Phe Ser Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp 
        275                 280                 285             


Cys Lys Gln Ala Phe His Asn Lys Val Thr Cys Phe Met Leu His His 
    290                 295                 300                 


Ile Glu Glu Pro Cys Ser Leu Gly Ala His Ala Ala Val Ile Val Pro 
305                 310                 315                 320 


Pro Thr Trp Ile Ile Lys Val Lys Lys Pro Gln Asn Ser Leu Lys Ala 
                325                 330                 335     


Ser Asn Arg Lys Lys Lys Arg Thr Ser Phe Lys Arg Lys Ala Ser Lys 
            340                 345                 350         


Arg Gly Met Glu Gln Glu Asn Lys Gly Arg Pro Phe Val Ile Lys Pro 
        355                 360                 365             


Ile Ser Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys 
    370                 375                 380                 


Ser Gly Gly Asn Gln Gly Thr Lys Val Leu Gln Met Phe Met Trp Tyr 
385                 390                 395                 400 


Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Glu Gly Pro Lys Asp 
                405                 410                 415     


Ala Leu Glu Leu Tyr Arg Lys Val Pro Asn Leu Arg Ile Leu Ala Cys 
            420                 425                 430         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Ile Leu Asp Glu Leu 
        435                 440                 445             


Gln Leu Ser Pro Gln Pro Pro Val Gly Val Leu Pro Leu Gly Thr Gly 
    450                 455                 460                 


Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu 
465                 470                 475                 480 


Pro Val Ser Lys Ile Leu Cys Gln Val Glu Asp Gly Thr Val Val Gln 
                485                 490                 495     


Leu Asp Arg Trp Asn Leu His Val Glu Arg Asn Pro Asp Leu Pro Pro 
            500                 505                 510         


Glu Glu Leu Glu Asp Gly Val Cys Lys Leu Pro Leu Asn Val Phe Asn 
        515                 520                 525             


Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His 
    530                 535                 540                 


Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn 
545                 550                 555                 560 


Lys Met Phe Tyr Ala Gly Ala Ala Phe Ser Asp Phe Leu Gln Arg Ser 
                565                 570                 575     


Ser Arg Asp Leu Ser Lys His Val Lys Val Val Cys Asp Gly Thr Asp 
            580                 585                 590         


Leu Thr Pro Lys Ile Gln Glu Leu Lys Phe Gln Cys Ile Val Phe Leu 
        595                 600                 605             


Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly Asn Pro Gly 
    610                 615                 620                 


Asp His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Ile Glu 
625                 630                 635                 640 


Val Ile Gly Phe Thr Met Ala Ser Leu Ala Ala Leu Gln Val Gly Gly 
                645                 650                 655     


His Gly Glu Arg Leu His Gln Cys Arg Glu Val Met Leu Leu Thr Tyr 
            660                 665                 670         


Lys Ser Ile Pro Met Gln Val Asp Gly Glu Pro Cys Arg Leu Ala Pro 
        675                 680                 685             


Ala Met Ile Arg Ile Ser Leu Arg Asn Gln Ala Asn Met Val Gln Lys 
    690                 695                 700                 


Ser Lys Arg Arg Thr Ser Met Pro Leu Leu Asn Asp Pro Gln Ser Val 
705                 710                 715                 720 


Pro Asp Arg Leu Arg Ile Arg Val Asn Lys Ile Ser Leu Gln Asp Tyr 
                725                 730                 735     


Glu Gly Phe His Tyr Asp Lys Glu Lys Leu Arg Glu Ala Ser Ile Ser 
            740                 745                 750         


Asp Trp Leu Arg Thr Ile Ala Gly Glu Leu Val Gln Ser Phe Gly Ala 
        755                 760                 765             


Ile Pro Leu Gly Ile Leu Val Val Arg Gly Asp Cys Asp Leu Glu Thr 
    770                 775                 780                 


Cys Arg Met Tyr Ile Asp Arg Leu Gln Glu Asp Leu Gln Ser Val Ser 
785                 790                 795                 800 


Ser Gly Ser Gln Arg Val His Tyr Gln Asp His Glu Thr Ser Phe Pro 
                805                 810                 815     


Arg Ala Leu Ser Ala Gln Arg Leu Ser Pro Arg Trp Cys Phe Leu Asp 
            820                 825                 830         


Asp Arg Ser Gln Glu His Leu His Phe Val Met Glu Ile Ser Gln Asp 
        835                 840                 845             


Glu Ile Phe Ile Leu Asp Pro Asp Met Val Val Ser Gln Pro Ala Gly 
    850                 855                 860                 


Thr Pro Pro Gly Met Pro Asp Leu Val Val Glu Gln Ala Ser Gly Ile 
865                 870                 875                 880 


Ser Asp Trp Trp Asn Pro Ala Leu Arg Lys Arg Met Leu Ser Asp Ser 
                885                 890                 895     


Gly Leu Gly Met Ile Ala Pro Tyr Tyr Glu Asp Ser Asp Leu Lys Asp 
            900                 905                 910         


Leu Ser His Ser Arg Val Leu Gln Ser Pro Val Ser Ser Glu Asp His 
        915                 920                 925             


Ala Ile Leu Gln Ala Val Ile Ala Gly Asp Leu Met Lys Leu Ile Glu 
    930                 935                 940                 


Ser Tyr Lys Asn Gly Gly Ser Leu Leu Ile Gln Gly Pro Asp His Cys 
945                 950                 955                 960 


Ser Leu Leu His Tyr Ala Ala Lys Thr Gly Asn Gly Glu Ile Val Lys 
                965                 970                 975     


Tyr Ile Leu Asp His Gly Pro Ser Glu Leu Leu Asp Met Ala Asp Ser 
            980                 985                 990         


Glu Thr Gly Glu Thr Ala Leu His  Lys Ala Ala Cys Gln  Arg Asn Arg 
        995                 1000                 1005             


Ala Val  Cys Gln Leu Leu Val  Asp Ala Gly Ala Ser  Leu Arg Lys 
    1010                 1015                 1020             


Thr Asp  Ser Lys Gly Lys Thr  Pro Gln Glu Arg Ala  Gln Gln Ala 
    1025                 1030                 1035             


Gly Asp  Pro Asp Leu Ala Ala  Tyr Leu Glu Ser Arg  Gln Asn Tyr 
    1040                 1045                 1050             


Lys Val  Ile Gly His Glu Asp  Leu Glu Thr Ala Val  
    1055                 1060                 1065 


<210>  3039
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKK__Homo_sapiens__NP_001013764

<400>  3039

Met Asp Arg Gly Ala Ala Ala Ala Gln Gly Thr Ala Pro Pro Gln Asp 
1               5                   10                  15      


Gly Glu Gln Pro Ala Glu Ser Pro Glu Pro Pro Pro Pro Trp Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Ala Pro Pro Pro Ala Pro Pro Leu Leu Ser Glu 
        35                  40                  45              


Ala Ser Pro Glu Pro Ile Pro Glu Pro Cys Pro Glu Leu Ala Pro Gly 
    50                  55                  60                  


Pro Cys Pro Glu Ala Thr Ser Glu Ser Ala Thr Glu Leu Tyr Thr Glu 
65                  70                  75                  80  


Pro Thr Pro Glu Pro Ala Thr Glu Pro Ala Ser Glu Pro Ala Pro Glu 
                85                  90                  95      


Pro Ala Thr Glu Pro Ala Pro Glu Pro Ala Thr Glu Pro Ala Pro Glu 
            100                 105                 110         


Pro Ala Pro Glu Pro Ala Thr Glu Ser Ala Pro Glu Pro Thr Pro Glu 
        115                 120                 125             


Pro Ala Leu Glu Ser Val Pro Glu Pro Ala Pro Glu Leu Thr Pro Glu 
    130                 135                 140                 


Val Ala Pro Glu Leu Ala Pro Glu Pro Thr Pro Glu Pro Val Thr Glu 
145                 150                 155                 160 


Leu Ala Pro Glu Phe Cys Pro Glu Ala Ala Pro Glu Phe Arg Pro Ser 
                165                 170                 175     


Pro Ala Pro Cys Leu Leu Gln Cys Pro Val Asp Thr Arg Glu Arg Gly 
            180                 185                 190         


Leu Lys Thr Ser Pro Ser Pro Ser Pro Ser Pro Ser Pro Arg Thr Pro 
        195                 200                 205             


Met Ser Trp Ser Arg Ile Lys Lys Ile Leu Lys Glu Gly Pro Met Leu 
    210                 215                 220                 


Lys Asn Cys Asn Ser Phe Lys Arg Trp Lys Leu Arg Tyr Phe Leu Val 
225                 230                 235                 240 


Gln Gly Gln Lys Leu Tyr Phe Ala His His Pro Ala Phe Ala His Phe 
                245                 250                 255     


Glu Thr Ile Asp Leu Ser Gln Ala Thr Val Ala Glu Ser Ser Cys Arg 
            260                 265                 270         


Asn Leu Cys His Ser Phe Cys Val Ile Thr Pro Gln Arg Lys Ile Thr 
        275                 280                 285             


Leu Ala Ala Pro Asn Arg Lys Asp Met Glu Glu Trp Ile Asn Ile Ile 
    290                 295                 300                 


Lys Thr Ile Gln Gln Gly Glu Ile Tyr Lys Ile Pro Ala Ala Glu Asn 
305                 310                 315                 320 


Asn Pro Phe Leu Val Gly Met His Cys Trp Tyr Ser Ser Tyr Ser His 
                325                 330                 335     


Arg Thr Gln His Cys Asn Val Cys Arg Glu Ser Ile Pro Ala Leu Ser 
            340                 345                 350         


Arg Asp Ala Ile Ile Cys Glu Val Cys Lys Val Lys Ser His Arg Leu 
        355                 360                 365             


Cys Ala Leu Arg Ala Ser Lys Asp Cys Lys Trp Asn Thr Leu Ser Ile 
    370                 375                 380                 


Thr Asp Asp Leu Leu Leu Pro Ala Asp Glu Val Asn Met Pro His Gln 
385                 390                 395                 400 


Trp Val Glu Gly Asn Met Pro Val Ser Ser Gln Cys Ala Val Cys His 
                405                 410                 415     


Glu Ser Cys Gly Ser Tyr Gln Arg Leu Gln Asp Phe Arg Cys Leu Trp 
            420                 425                 430         


Cys Asn Ser Thr Val His Asp Asp Cys Arg Arg Arg Phe Ser Lys Glu 
        435                 440                 445             


Cys Cys Phe Arg Ser His Arg Ser Ser Val Ile Pro Pro Thr Ala Leu 
    450                 455                 460                 


Ser Asp Pro Lys Gly Asp Gly Gln Leu Val Val Ser Ser Asp Phe Trp 
465                 470                 475                 480 


Asn Leu Asp Trp Ser Ser Ala Cys Ser Cys Pro Leu Leu Ile Phe Ile 
                485                 490                 495     


Asn Ser Lys Ser Gly Asp His Gln Gly Ile Val Phe Leu Arg Lys Phe 
            500                 505                 510         


Lys Gln Tyr Leu Asn Pro Ser Gln Val Phe Asp Leu Leu Lys Gly Gly 
        515                 520                 525             


Pro Glu Ala Gly Leu Ser Met Phe Lys Asn Phe Ala Arg Phe Arg Ile 
    530                 535                 540                 


Leu Val Cys Gly Gly Asp Gly Ser Val Ser Trp Val Leu Ser Leu Ile 
545                 550                 555                 560 


Asp Ala Phe Gly Leu His Glu Lys Cys Gln Leu Ala Val Ile Pro Leu 
                565                 570                 575     


Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Ala Phe Trp 
            580                 585                 590         


Asn Lys Ser Lys Ser Pro Leu Asp Ile Leu Asn Arg Val Glu Gln Ala 
        595                 600                 605             


Ser Val Arg Ile Leu Asp Arg Trp Ser Val Met Ile Arg Glu Thr Pro 
    610                 615                 620                 


Arg Gln Thr Pro Leu Leu Lys Gly Gln Val Glu Met Asp Val Pro Arg 
625                 630                 635                 640 


Phe Glu Ala Ala Ala Ile Gln His Leu Glu Ser Ala Ala Thr Glu Leu 
                645                 650                 655     


Asn Lys Ile Leu Lys Ala Lys Tyr Pro Thr Glu Met Ile Ile Ala Thr 
            660                 665                 670         


Arg Phe Leu Cys Ser Ala Val Glu Asp Phe Val Val Asp Ile Val Lys 
        675                 680                 685             


Ala Trp Gly Gln Ile Lys Gln Asn Asn Thr Ala Ile Val Ser Val Ile 
    690                 695                 700                 


Leu Lys Ser Asp Leu Met Tyr Asp Arg Leu Ser Val Leu Ile Asp Val 
705                 710                 715                 720 


Leu Ala Glu Glu Ala Ala Ala Thr Ser Ala Glu Lys Ser Ala Thr Glu 
                725                 730                 735     


Tyr Ala Asp Ser Ser Lys Ala Asp Arg Lys Pro Phe Ile Pro Gln Ile 
            740                 745                 750         


Asp His Ile Ala Lys Cys Lys Leu Glu Leu Ala Thr Lys Ala Gln Ser 
        755                 760                 765             


Leu Gln Lys Ser Leu Lys Leu Ile Ile Phe Gln Val Glu Gln Ala Leu 
    770                 775                 780                 


Asp Glu Glu Ser Arg Gln Thr Ile Ser Val Lys Asn Phe Ser Ser Thr 
785                 790                 795                 800 


Phe Phe Leu Glu Asp Asp Pro Glu Asp Ile Asn Gln Thr Ser Pro Arg 
                805                 810                 815     


Arg Arg Ser Arg Arg Gly Thr Leu Ser Ser Ile Ser Ser Leu Lys Ser 
            820                 825                 830         


Glu Asp Leu Asp Asn Leu Asn Leu Asp His Leu His Phe Thr Pro Glu 
        835                 840                 845             


Ser Ile Arg Phe Lys Glu Lys Cys Val Met Asn Asn Tyr Phe Gly Ile 
    850                 855                 860                 


Gly Leu Asp Ala Lys Ile Ser Leu Asp Phe Asn Thr Arg Arg Asp Glu 
865                 870                 875                 880 


His Pro Gly Gln Tyr Asn Ser Arg Leu Lys Asn Lys Met Trp Tyr Gly 
                885                 890                 895     


Leu Leu Gly Thr Lys Glu Leu Leu Gln Arg Ser Tyr Arg Lys Leu Glu 
            900                 905                 910         


Glu Arg Val His Leu Glu Cys Asp Gly Glu Thr Ile Ser Leu Pro Asn 
        915                 920                 925             


Leu Gln Gly Ile Val Val Leu Asn Ile Thr Ser Tyr Ala Gly Gly Ile 
    930                 935                 940                 


Asn Phe Trp Gly Ser Asn Thr Ala Thr Thr Glu Tyr Glu Ala Pro Ala 
945                 950                 955                 960 


Ile Asp Asp Gly Lys Leu Glu Val Val Ala Ile Phe Gly Ser Val Gln 
                965                 970                 975     


Met Ala Met Ser Arg Ile Ile Asn Leu His His His Arg Ile Ala Gln 
            980                 985                 990         


Cys His Glu Val Met Ile Thr Ile  Asp Gly Glu Glu Gly  Ile Pro Val 
        995                 1000                 1005             


Gln Val  Asp Gly Glu Ala Trp  Ile Gln Arg Pro Gly  Leu Ile Lys 
    1010                 1015                 1020             


Ile Arg  Tyr Lys Asn Ala Ala  Gln Met Leu Thr Arg  Asp Arg Asp 
    1025                 1030                 1035             


Phe Glu  Asn Ser Met Lys Met  Trp Glu Tyr Lys His  Thr Glu Ile 
    1040                 1045                 1050             


Gln Ala  Ala Pro Gln Pro Gln  Leu Asp Phe Gln Asp  Ser Gln Glu 
    1055                 1060                 1065             


Ser Leu  Ser Asp Glu Glu Tyr  Ala Gln Met Gln His  Leu Ala Arg 
    1070                 1075                 1080             


Leu Ala  Glu Asn Leu Ile Ser  Lys Leu Asn Asp Leu  Ser Lys Ile 
    1085                 1090                 1095             


His Gln  His Val Ser Val Leu  Met Gly Ser Val Asn  Ala Ser Ala 
    1100                 1105                 1110             


Asn Ile  Leu Asn Asp Ile Phe  Tyr Gly Gln Asp Ser  Gly Asn Glu 
    1115                 1120                 1125             


Met Gly  Ala Ala Ser Cys Ile  Pro Ile Glu Thr Leu  Ser Arg Asn 
    1130                 1135                 1140             


Asp Ala  Val Asp Val Thr Phe  Ser Leu Lys Gly Leu  Tyr Asp Asp 
    1145                 1150                 1155             


Thr Thr  Ala Phe Leu Asp Glu  Lys Leu Leu Arg Ser  Ala Glu Asp 
    1160                 1165                 1170             


Glu Thr  Ala Leu Gln Ser Ala  Leu Asp Ala Met Asn  Lys Glu Phe 
    1175                 1180                 1185             


Lys Lys  Leu Ser Glu Ile Asp  Trp Met Asn Pro Ile  Phe Val Pro 
    1190                 1195                 1200             


Glu Glu  Lys Ser Ser Asp Thr  Asp Ser Arg Ser Leu  Arg Leu Lys 
    1205                 1210                 1215             


Ile Lys  Phe Pro Lys Leu Gly  Lys Lys Lys Val Glu  Glu Glu Arg 
    1220                 1225                 1230             


Lys Pro  Lys Ser Gly Gln Ser  Val Gln Ser Phe Ile  Gly Asn Leu 
    1235                 1240                 1245             


Trp His  Arg Arg His Arg Glu  Asp Glu Ala Glu Gly  Asp Asp Pro 
    1250                 1255                 1260             


Leu Thr  Pro Ser Arg Ser Gln  Leu 
    1265                 1270     


<210>  3040
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKQ__Homo_sapiens__NP_001338

<400>  3040

Met Ala Ala Ala Ala Glu Pro Gly Ala Arg Ala Trp Leu Gly Gly Gly 
1               5                   10                  15      


Ser Pro Arg Pro Gly Ser Pro Ala Cys Ser Pro Val Leu Gly Ser Gly 
            20                  25                  30          


Gly Arg Ala Arg Pro Gly Pro Gly Pro Gly Pro Gly Pro Glu Arg Ala 
        35                  40                  45              


Gly Val Arg Ala Pro Gly Pro Ala Ala Ala Pro Gly His Ser Phe Arg 
    50                  55                  60                  


Lys Val Thr Leu Thr Lys Pro Thr Phe Cys His Leu Cys Ser Asp Phe 
65                  70                  75                  80  


Ile Trp Gly Leu Ala Gly Phe Leu Cys Asp Val Cys Asn Phe Met Ser 
                85                  90                  95      


His Glu Lys Cys Leu Lys His Val Arg Ile Pro Cys Thr Ser Val Ala 
            100                 105                 110         


Pro Ser Leu Val Arg Val Pro Val Ala His Cys Phe Gly Pro Arg Gly 
        115                 120                 125             


Leu His Lys Arg Lys Phe Cys Ala Val Cys Arg Lys Val Leu Glu Ala 
    130                 135                 140                 


Pro Ala Leu His Cys Glu Val Cys Glu Leu His Leu His Pro Asp Cys 
145                 150                 155                 160 


Val Pro Phe Ala Cys Ser Asp Cys Arg Gln Cys His Gln Asp Gly His 
                165                 170                 175     


Gln Asp His Asp Thr His His His His Trp Arg Glu Gly Asn Leu Pro 
            180                 185                 190         


Ser Gly Ala Arg Cys Glu Val Cys Arg Lys Thr Cys Gly Ser Ser Asp 
        195                 200                 205             


Val Leu Ala Gly Val Arg Cys Glu Trp Cys Gly Val Gln Ala His Ser 
    210                 215                 220                 


Leu Cys Ser Ala Ala Leu Ala Pro Glu Cys Gly Phe Gly Arg Leu Arg 
225                 230                 235                 240 


Ser Leu Val Leu Pro Pro Ala Cys Val Arg Leu Leu Pro Gly Gly Phe 
                245                 250                 255     


Ser Lys Thr Gln Ser Phe Arg Ile Val Glu Ala Ala Glu Pro Gly Glu 
            260                 265                 270         


Gly Gly Asp Gly Ala Asp Gly Ser Ala Ala Val Gly Pro Gly Arg Glu 
        275                 280                 285             


Thr Gln Ala Thr Pro Glu Ser Gly Lys Gln Thr Leu Lys Ile Phe Asp 
    290                 295                 300                 


Gly Asp Asp Ala Val Arg Arg Ser Gln Phe Arg Leu Val Thr Val Ser 
305                 310                 315                 320 


Arg Leu Ala Gly Ala Glu Glu Val Leu Glu Ala Ala Leu Arg Ala His 
                325                 330                 335     


His Ile Pro Glu Asp Pro Gly His Leu Glu Leu Cys Arg Leu Pro Pro 
            340                 345                 350         


Ser Ser Gln Ala Cys Asp Ala Trp Ala Gly Gly Lys Ala Gly Ser Ala 
        355                 360                 365             


Val Ile Ser Glu Glu Gly Arg Ser Pro Gly Ser Gly Glu Ala Thr Pro 
    370                 375                 380                 


Glu Ala Trp Val Ile Arg Ala Leu Pro Arg Ala Gln Glu Val Leu Lys 
385                 390                 395                 400 


Ile Tyr Pro Gly Trp Leu Lys Val Gly Val Ala Tyr Val Ser Val Arg 
                405                 410                 415     


Val Thr Pro Lys Ser Thr Ala Arg Ser Val Val Leu Glu Val Leu Pro 
            420                 425                 430         


Leu Leu Gly Arg Gln Ala Glu Ser Pro Glu Ser Phe Gln Leu Val Glu 
        435                 440                 445             


Val Ala Met Gly Cys Arg His Val Gln Arg Thr Met Leu Met Asp Glu 
    450                 455                 460                 


Gln Pro Leu Leu Asp Arg Leu Gln Asp Ile Arg Gln Met Ser Val Arg 
465                 470                 475                 480 


Gln Val Ser Gln Thr Arg Phe Tyr Val Ala Glu Ser Arg Asp Val Ala 
                485                 490                 495     


Pro His Val Ser Leu Phe Val Gly Gly Leu Pro Pro Gly Leu Ser Pro 
            500                 505                 510         


Glu Glu Tyr Ser Ser Leu Leu His Glu Ala Gly Ala Thr Lys Ala Thr 
        515                 520                 525             


Val Val Ser Val Ser His Ile Tyr Ser Ser Gln Gly Ala Val Val Leu 
    530                 535                 540                 


Asp Val Ala Cys Phe Ala Glu Ala Glu Arg Leu Tyr Met Leu Leu Lys 
545                 550                 555                 560 


Asp Met Ala Val Arg Gly Arg Leu Leu Thr Ala Leu Val Leu Pro Asp 
                565                 570                 575     


Leu Leu His Ala Lys Leu Pro Pro Asp Ser Cys Pro Leu Leu Val Phe 
            580                 585                 590         


Val Asn Pro Lys Ser Gly Gly Leu Lys Gly Arg Asp Leu Leu Cys Ser 
        595                 600                 605             


Phe Arg Lys Leu Leu Asn Pro His Gln Val Phe Asp Leu Thr Asn Gly 
    610                 615                 620                 


Gly Pro Leu Pro Gly Leu His Leu Phe Ser Gln Val Pro Cys Phe Arg 
625                 630                 635                 640 


Val Leu Val Cys Gly Gly Asp Gly Thr Val Gly Trp Val Leu Gly Ala 
                645                 650                 655     


Leu Glu Glu Thr Arg Tyr Arg Leu Ala Cys Pro Glu Pro Ser Val Ala 
            660                 665                 670         


Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Gly Arg Val Leu Arg Trp 
        675                 680                 685             


Gly Ala Gly Tyr Ser Gly Glu Asp Pro Phe Ser Val Leu Leu Ser Val 
    690                 695                 700                 


Asp Glu Ala Asp Ala Val Leu Met Asp Arg Trp Thr Ile Leu Leu Asp 
705                 710                 715                 720 


Ala His Glu Ala Gly Ser Ala Glu Asn Asp Thr Ala Asp Ala Glu Pro 
                725                 730                 735     


Pro Lys Ile Val Gln Met Ser Asn Tyr Cys Gly Ile Gly Ile Asp Ala 
            740                 745                 750         


Glu Leu Ser Leu Asp Phe His Gln Ala Arg Glu Glu Glu Pro Gly Lys 
        755                 760                 765             


Phe Thr Ser Arg Leu His Asn Lys Gly Val Tyr Val Arg Val Gly Leu 
    770                 775                 780                 


Gln Lys Ile Ser His Ser Arg Ser Leu His Lys Gln Ile Arg Leu Gln 
785                 790                 795                 800 


Val Glu Arg Gln Glu Val Glu Leu Pro Ser Ile Glu Gly Leu Ile Phe 
                805                 810                 815     


Ile Asn Ile Pro Ser Trp Gly Ser Gly Ala Asp Leu Trp Gly Ser Asp 
            820                 825                 830         


Ser Asp Thr Arg Phe Glu Lys Pro Arg Met Asp Asp Gly Leu Leu Glu 
        835                 840                 845             


Val Val Gly Val Thr Gly Val Val His Met Gly Gln Val Gln Gly Gly 
    850                 855                 860                 


Leu Arg Ser Gly Ile Arg Ile Ala Gln Gly Ser Tyr Phe Arg Val Thr 
865                 870                 875                 880 


Leu Leu Lys Ala Thr Pro Val Gln Val Asp Gly Glu Pro Trp Val Gln 
                885                 890                 895     


Ala Pro Gly His Met Ile Ile Ser Ala Ala Gly Pro Lys Val His Met 
            900                 905                 910         


Leu Arg Lys Ala Lys Gln Lys Pro Arg Arg Ala Gly Thr Thr Arg Asp 
        915                 920                 925             


Ala Arg Ala Asp Ala Ala Pro Ala Pro Glu Ser Asp Pro Arg 
    930                 935                 940         


<210>  3041
<211>  1117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGKZ__Homo_sapiens__NP_001099010

<400>  3041

Met Glu Thr Phe Phe Arg Arg His Phe Arg Gly Lys Val Pro Gly Pro 
1               5                   10                  15      


Gly Glu Gly Gln Gln Arg Pro Ser Ser Val Gly Leu Pro Thr Gly Lys 
            20                  25                  30          


Ala Arg Arg Arg Ser Pro Ala Gly Gln Ala Ser Ser Ser Leu Ala Gln 
        35                  40                  45              


Arg Arg Arg Ser Ser Ala Gln Leu Gln Gly Cys Leu Leu Ser Cys Gly 
    50                  55                  60                  


Val Arg Ala Gln Gly Ser Ser Arg Arg Arg Ser Ser Thr Val Pro Pro 
65                  70                  75                  80  


Ser Cys Asn Pro Arg Phe Ile Val Asp Lys Val Leu Thr Pro Gln Pro 
                85                  90                  95      


Thr Thr Val Gly Ala Gln Leu Leu Gly Ala Pro Leu Leu Leu Thr Gly 
            100                 105                 110         


Leu Val Gly Met Asn Glu Glu Glu Gly Val Gln Glu Asp Val Val Ala 
        115                 120                 125             


Glu Ala Ser Ser Ala Ile Gln Pro Gly Thr Lys Thr Pro Gly Pro Pro 
    130                 135                 140                 


Pro Pro Arg Gly Ala Gln Pro Leu Leu Pro Leu Pro Arg Tyr Leu Arg 
145                 150                 155                 160 


Arg Ala Ser Ser His Leu Leu Pro Ala Asp Ala Val Tyr Asp His Ala 
                165                 170                 175     


Leu Trp Gly Leu His Gly Tyr Tyr Arg Arg Leu Ser Gln Arg Arg Pro 
            180                 185                 190         


Ser Gly Gln His Pro Gly Pro Gly Gly Arg Arg Ala Ser Gly Thr Thr 
        195                 200                 205             


Ala Gly Thr Met Leu Pro Thr Arg Val Arg Pro Leu Ser Arg Arg Arg 
    210                 215                 220                 


Gln Val Ala Leu Arg Arg Lys Ala Ala Gly Pro Gln Ala Trp Ser Ala 
225                 230                 235                 240 


Leu Leu Ala Lys Ala Ile Thr Lys Ser Gly Leu Gln His Leu Ala Pro 
                245                 250                 255     


Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu Arg Gln Ile 
            260                 265                 270         


Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly Glu His Ile 
        275                 280                 285             


Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val Gly Glu Gln 
    290                 295                 300                 


Tyr Cys Val Ala Arg Met Leu Lys Ser Val Ser Arg Arg Lys Cys Ala 
305                 310                 315                 320 


Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu Gln Leu Glu Lys 
                325                 330                 335     


Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser Gly Ser Arg Asn 
            340                 345                 350         


Val Arg Glu Pro Thr Phe Val Arg His His Trp Val His Arg Arg Arg 
        355                 360                 365             


Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe Gln Gln Lys Phe 
    370                 375                 380                 


Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp Cys Lys 
385                 390                 395                 400 


Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu Gln Gln Ile Glu 
                405                 410                 415     


Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val Ile Pro Pro Thr 
            420                 425                 430         


Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu Lys Ala Ser Lys 
        435                 440                 445             


Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser Lys Lys Gly Pro 
    450                 455                 460                 


Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro Thr Pro Ser Pro 
465                 470                 475                 480 


Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Asn 
                485                 490                 495     


Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr Leu Asn Pro Arg 
            500                 505                 510         


Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu Ala Leu Glu Met 
        515                 520                 525             


Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys Gly Gly Asp Gly 
    530                 535                 540                 


Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu Arg Leu Lys Pro 
545                 550                 555                 560 


Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala 
                565                 570                 575     


Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu Pro Val Ser Lys 
            580                 585                 590         


Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln Leu Asp Arg Trp 
        595                 600                 605             


Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro Glu Asp Arg Asp 
    610                 615                 620                 


Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe Asn Asn Tyr Phe 
625                 630                 635                 640 


Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His Glu Ser Arg 
                645                 650                 655     


Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn Lys Met Phe 
            660                 665                 670         


Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly Ser Ser Lys Asp 
        675                 680                 685             


Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met Asp Leu Thr Pro 
    690                 695                 700                 


Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe Leu Asn Ile Pro 
705                 710                 715                 720 


Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro Gly Glu His His 
                725                 730                 735     


Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu Glu Val Ile Gly 
            740                 745                 750         


Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly Gly His Gly Glu 
        755                 760                 765             


Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr Ser Lys Ala Ile 
    770                 775                 780                 


Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala Ala Ser Arg Ile 
785                 790                 795                 800 


Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln Lys Ala Lys Arg 
                805                 810                 815     


Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro Val Pro Glu Gln 
            820                 825                 830         


Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp Tyr Glu Ala Leu 
        835                 840                 845             


His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val Pro Leu Gly Thr 
    850                 855                 860                 


Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys Arg Ala His Ile 
865                 870                 875                 880 


Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala Lys Ser Pro Thr 
                885                 890                 895     


Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp Ala Thr Thr Ala 
            900                 905                 910         


Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His Leu Asn Tyr Val 
        915                 920                 925             


Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp Pro Glu Leu Leu 
    930                 935                 940                 


Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr Ser Pro Leu Pro 
945                 950                 955                 960 


Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln Gly Asp Ala Ala 
                965                 970                 975     


Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys Arg Asn Asp Phe 
            980                 985                 990         


Cys Lys Leu Gln Glu Leu His Arg  Ala Gly Gly Asp Leu  Met His Arg 
        995                 1000                 1005             


Asp Glu  Gln Ser Arg Thr Leu  Leu His His Ala Val  Ser Thr Gly 
    1010                 1015                 1020             


Ser Lys  Asp Val Val Arg Tyr  Leu Leu Asp His Ala  Pro Pro Glu 
    1025                 1030                 1035             


Ile Leu  Asp Ala Val Glu Glu  Asn Gly Glu Thr Cys  Leu His Gln 
    1040                 1045                 1050             


Ala Ala  Ala Leu Gly Gln Arg  Thr Ile Cys His Tyr  Ile Val Glu 
    1055                 1060                 1065             


Ala Gly  Ala Ser Leu Met Lys  Thr Asp Gln Gln Gly  Asp Thr Pro 
    1070                 1075                 1080             


Arg Gln  Arg Ala Glu Lys Ala  Gln Asp Thr Glu Leu  Ala Ala Tyr 
    1085                 1090                 1095             


Leu Glu  Asn Arg Gln His Tyr  Gln Met Ile Gln Arg  Glu Asp Gln 
    1100                 1105                 1110             


Glu Thr  Ala Val 
    1115         


<210>  3042
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DGUOK__Homo_sapiens__NP_550438

<400>  3042

Met Ala Ala Gly Arg Leu Phe Leu Ser Arg Leu Arg Ala Pro Phe Ser 
1               5                   10                  15      


Ser Met Ala Lys Ser Pro Leu Glu Gly Val Ser Ser Ser Arg Gly Leu 
            20                  25                  30          


His Ala Gly Arg Gly Pro Arg Arg Leu Ser Ile Glu Gly Asn Ile Ala 
        35                  40                  45              


Val Gly Lys Ser Thr Phe Val Lys Leu Leu Thr Lys Thr Tyr Pro Glu 
    50                  55                  60                  


Trp His Val Ala Thr Glu Pro Val Ala Thr Trp Gln Asn Ile Gln Ala 
65                  70                  75                  80  


Ala Gly Thr Gln Lys Ala Cys Thr Ala Gln Ser Leu Gly Asn Leu Leu 
                85                  90                  95      


Asp Met Met Tyr Arg Glu Pro Ala Arg Trp Ser Tyr Thr Phe Gln Thr 
            100                 105                 110         


Phe Ser Phe Leu Ser Arg Leu Lys Val Gln Leu Glu Pro Phe Pro Glu 
        115                 120                 125             


Lys Leu Leu Gln Ala Arg Lys Pro Val Gln Ile Phe Glu Arg Ser Val 
    130                 135                 140                 


Tyr Ser Asp Arg Tyr Ile Phe Ala Lys Asn Leu Phe Glu Asn Gly Ser 
145                 150                 155                 160 


Leu Ser Asp Ile Glu Trp His Ile Tyr Gln Asp Trp His Ser Phe Leu 
                165                 170                 175     


Leu Trp Glu Phe Ala Ser Arg Ile Thr Leu His Gly Phe Ile Tyr Leu 
            180                 185                 190         


Gln Ala Ser Pro Gln Val Cys Leu Lys Arg Leu Tyr Gln Arg Ala Arg 
        195                 200                 205             


Glu Glu Glu Lys Gly Ile Glu Leu Ala Tyr Leu Glu Gln Leu His Gly 
    210                 215                 220                 


Gln His Glu Ala Trp Leu Ile His Lys Thr Thr Lys Leu His Phe Glu 
225                 230                 235                 240 


Ala Leu Met Asn Ile Pro Val Leu Val Leu Asp Val Asn Asp Asp Phe 
                245                 250                 255     


Ser Glu Glu Val Thr Lys Gln Glu Asp Leu Met Arg Glu Val Asn Thr 
            260                 265                 270         


Phe Val Lys Asn Leu 
        275         


<210>  3043
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHCR7__Homo_sapiens__NP_001157289

<400>  3043

Met Ala Ala Lys Ser Gln Pro Asn Ile Pro Lys Ala Lys Ser Leu Asp 
1               5                   10                  15      


Gly Val Thr Asn Asp Arg Thr Ala Ser Gln Gly Gln Trp Gly Arg Ala 
            20                  25                  30          


Trp Glu Val Asp Trp Phe Ser Leu Ala Ser Val Ile Phe Leu Leu Leu 
        35                  40                  45              


Phe Ala Pro Phe Ile Val Tyr Tyr Phe Ile Met Ala Cys Asp Gln Tyr 
    50                  55                  60                  


Ser Cys Ala Leu Thr Gly Pro Val Val Asp Ile Val Thr Gly His Ala 
65                  70                  75                  80  


Arg Leu Ser Asp Ile Trp Ala Lys Thr Pro Pro Ile Thr Arg Lys Ala 
                85                  90                  95      


Ala Gln Leu Tyr Thr Leu Trp Val Thr Phe Gln Val Leu Leu Tyr Thr 
            100                 105                 110         


Ser Leu Pro Asp Phe Cys His Lys Phe Leu Pro Gly Tyr Val Gly Gly 
        115                 120                 125             


Ile Gln Glu Gly Ala Val Thr Pro Ala Gly Val Val Asn Lys Tyr Gln 
    130                 135                 140                 


Ile Asn Gly Leu Gln Ala Trp Leu Leu Thr His Leu Leu Trp Phe Ala 
145                 150                 155                 160 


Asn Ala His Leu Leu Ser Trp Phe Ser Pro Thr Ile Ile Phe Asp Asn 
                165                 170                 175     


Trp Ile Pro Leu Leu Trp Cys Ala Asn Ile Leu Gly Tyr Ala Val Ser 
            180                 185                 190         


Thr Phe Ala Met Val Lys Gly Tyr Phe Phe Pro Thr Ser Ala Arg Asp 
        195                 200                 205             


Cys Lys Phe Thr Gly Asn Phe Phe Tyr Asn Tyr Met Met Gly Ile Glu 
    210                 215                 220                 


Phe Asn Pro Arg Ile Gly Lys Trp Phe Asp Phe Lys Leu Phe Phe Asn 
225                 230                 235                 240 


Gly Arg Pro Gly Ile Val Ala Trp Thr Leu Ile Asn Leu Ser Phe Ala 
                245                 250                 255     


Ala Lys Gln Arg Glu Leu His Ser His Val Thr Asn Ala Met Val Leu 
            260                 265                 270         


Val Asn Val Leu Gln Ala Ile Tyr Val Ile Asp Phe Phe Trp Asn Glu 
        275                 280                 285             


Thr Trp Tyr Leu Lys Thr Ile Asp Ile Cys His Asp His Phe Gly Trp 
    290                 295                 300                 


Tyr Leu Gly Trp Gly Asp Cys Val Trp Leu Pro Tyr Leu Tyr Thr Leu 
305                 310                 315                 320 


Gln Gly Leu Tyr Leu Val Tyr His Pro Val Gln Leu Ser Thr Pro His 
                325                 330                 335     


Ala Val Gly Val Leu Leu Leu Gly Leu Val Gly Tyr Tyr Ile Phe Arg 
            340                 345                 350         


Val Ala Asn His Gln Lys Asp Leu Phe Arg Arg Thr Asp Gly Arg Cys 
        355                 360                 365             


Leu Ile Trp Gly Arg Lys Pro Lys Val Ile Glu Cys Ser Tyr Thr Ser 
    370                 375                 380                 


Ala Asp Gly Gln Arg His His Ser Lys Leu Leu Val Ser Gly Phe Trp 
385                 390                 395                 400 


Gly Val Ala Arg His Phe Asn Tyr Val Gly Asp Leu Met Gly Ser Leu 
                405                 410                 415     


Ala Tyr Cys Leu Ala Cys Gly Gly Gly His Leu Leu Pro Tyr Phe Tyr 
            420                 425                 430         


Ile Ile Tyr Met Ala Ile Leu Leu Thr His Arg Cys Leu Arg Asp Glu 
        435                 440                 445             


His Arg Cys Ala Ser Lys Tyr Gly Arg Asp Trp Glu Arg Tyr Thr Ala 
    450                 455                 460                 


Ala Val Pro Tyr Arg Leu Leu Pro Gly Ile Phe 
465                 470                 475 


<210>  3044
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHDH__Homo_sapiens__NP_055290

<400>  3044

Met Ala Leu Arg Trp Gly Ile Val Ser Val Gly Leu Ile Ser Ser Asp 
1               5                   10                  15      


Phe Thr Ala Val Leu Gln Thr Leu Pro Arg Ser Glu His Gln Val Val 
            20                  25                  30          


Ala Val Ala Ala Arg Asp Leu Ser Arg Ala Lys Glu Phe Ala Gln Lys 
        35                  40                  45              


His Asp Ile Pro Lys Ala Tyr Gly Ser Tyr Glu Glu Leu Ala Lys Asp 
    50                  55                  60                  


Pro Ser Val Glu Val Ala Tyr Ile Gly Thr Gln His Pro Gln His Lys 
65                  70                  75                  80  


Ala Ala Val Met Leu Cys Leu Ala Ala Gly Lys Ala Val Leu Cys Glu 
                85                  90                  95      


Lys Pro Thr Gly Val Asn Ala Ala Glu Val Arg Glu Met Val Ala Glu 
            100                 105                 110         


Ala Arg Ser Arg Ala Leu Phe Leu Met Glu Ala Ile Trp Thr Arg Phe 
        115                 120                 125             


Phe Pro Ala Ser Glu Ala Leu Arg Ser Val Leu Ala Gln Gly Thr Leu 
    130                 135                 140                 


Gly Asp Leu Arg Val Ala Arg Ala Glu Phe Gly Lys Asn Leu Ile His 
145                 150                 155                 160 


Val Pro Arg Ala Val Asp Arg Ala Gln Ala Gly Gly Ala Leu Leu Asp 
                165                 170                 175     


Ile Gly Ile Tyr Cys Val Gln Phe Thr Ser Met Val Phe Gly Gly Gln 
            180                 185                 190         


Lys Pro Glu Lys Ile Ser Val Val Gly Arg Arg His Glu Thr Gly Val 
        195                 200                 205             


Asp Asp Thr Val Thr Val Leu Leu Gln Tyr Pro Gly Glu Val His Gly 
    210                 215                 220                 


Ser Phe Thr Cys Ser Ile Thr Val Gln Leu Ser Asn Thr Ala Ser Val 
225                 230                 235                 240 


Ser Gly Thr Lys Gly Met Val Gln Leu Leu Asn Pro Cys Trp Cys Pro 
                245                 250                 255     


Thr Glu Leu Val Val Lys Gly Glu His Lys Glu Phe Pro Leu Pro Pro 
            260                 265                 270         


Val Pro Lys Asp Cys Asn Phe Asp Asn Gly Ala Gly Met Ser Tyr Glu 
        275                 280                 285             


Ala Lys His Val Trp Glu Cys Leu Arg Lys Gly Met Lys Glu Ser Pro 
    290                 295                 300                 


Val Ile Pro Leu Ser Glu Ser Glu Leu Leu Ala Asp Ile Leu Glu Glu 
305                 310                 315                 320 


Val Arg Lys Ala Ile Gly Val Thr Phe Pro Gln Asp Lys Arg 
                325                 330                 


<210>  3045
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHFR__Homo_sapiens__NP_000782

<400>  3045

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  3046
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHFRL1__Homo_sapiens__NP_001182572

<400>  3046

Met Phe Leu Leu Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Arg Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Asp Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ala Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Arg Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Ile Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Leu Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Ser Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Gly Lys His Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Cys Glu Lys Asp Asp 
            180                 185         


<210>  3047
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHH__Homo_sapiens__NP_066382

<400>  3047

Met Ala Leu Leu Thr Asn Leu Leu Pro Leu Cys Cys Leu Ala Leu Leu 
1               5                   10                  15      


Ala Leu Pro Ala Gln Ser Cys Gly Pro Gly Arg Gly Pro Val Gly Arg 
            20                  25                  30          


Arg Arg Tyr Ala Arg Lys Gln Leu Val Pro Leu Leu Tyr Lys Gln Phe 
        35                  40                  45              


Val Pro Gly Val Pro Glu Arg Thr Leu Gly Ala Ser Gly Pro Ala Glu 
    50                  55                  60                  


Gly Arg Val Ala Arg Gly Ser Glu Arg Phe Arg Asp Leu Val Pro Asn 
65                  70                  75                  80  


Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Ser Gly Ala Asp 
                85                  90                  95      


Arg Leu Met Thr Glu Arg Cys Lys Glu Arg Val Asn Ala Leu Ala Ile 
            100                 105                 110         


Ala Val Met Asn Met Trp Pro Gly Val Arg Leu Arg Val Thr Glu Gly 
        115                 120                 125             


Trp Asp Glu Asp Gly His His Ala Gln Asp Ser Leu His Tyr Glu Gly 
    130                 135                 140                 


Arg Ala Leu Asp Ile Thr Thr Ser Asp Arg Asp Arg Asn Lys Tyr Gly 
145                 150                 155                 160 


Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr 
                165                 170                 175     


Glu Ser Arg Asn His Val His Val Ser Val Lys Ala Asp Asn Ser Leu 
            180                 185                 190         


Ala Val Arg Ala Gly Gly Cys Phe Pro Gly Asn Ala Thr Val Arg Leu 
        195                 200                 205             


Trp Ser Gly Glu Arg Lys Gly Leu Arg Glu Leu His Arg Gly Asp Trp 
    210                 215                 220                 


Val Leu Ala Ala Asp Ala Ser Gly Arg Val Val Pro Thr Pro Val Leu 
225                 230                 235                 240 


Leu Phe Leu Asp Arg Asp Leu Gln Arg Arg Ala Ser Phe Val Ala Val 
                245                 250                 255     


Glu Thr Glu Trp Pro Pro Arg Lys Leu Leu Leu Thr Pro Trp His Leu 
            260                 265                 270         


Val Phe Ala Ala Arg Gly Pro Ala Pro Ala Pro Gly Asp Phe Ala Pro 
        275                 280                 285             


Val Phe Ala Arg Arg Leu Arg Ala Gly Asp Ser Val Leu Ala Pro Gly 
    290                 295                 300                 


Gly Asp Ala Leu Arg Pro Ala Arg Val Ala Arg Val Ala Arg Glu Glu 
305                 310                 315                 320 


Ala Val Gly Val Phe Ala Pro Leu Thr Ala His Gly Thr Leu Leu Val 
                325                 330                 335     


Asn Asp Val Leu Ala Ser Cys Tyr Ala Val Leu Glu Ser His Gln Trp 
            340                 345                 350         


Ala His Arg Ala Phe Ala Pro Leu Arg Leu Leu His Ala Leu Gly Ala 
        355                 360                 365             


Leu Leu Pro Gly Gly Ala Val Gln Pro Thr Gly Met His Trp Tyr Ser 
    370                 375                 380                 


Arg Leu Leu Tyr Arg Leu Ala Glu Glu Leu Leu Gly 
385                 390                 395     


<210>  3048
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHODH__Homo_sapiens__NP_001352

<400>  3048

Met Ala Trp Arg His Leu Lys Lys Arg Ala Gln Asp Ala Val Ile Ile 
1               5                   10                  15      


Leu Gly Gly Gly Gly Leu Leu Phe Ala Ser Tyr Leu Met Ala Thr Gly 
            20                  25                  30          


Asp Glu Arg Phe Tyr Ala Glu His Leu Met Pro Thr Leu Gln Gly Leu 
        35                  40                  45              


Leu Asp Pro Glu Ser Ala His Arg Leu Ala Val Arg Phe Thr Ser Leu 
    50                  55                  60                  


Gly Leu Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp Met Leu Glu Val 
65                  70                  75                  80  


Arg Val Leu Gly His Lys Phe Arg Asn Pro Val Gly Ile Ala Ala Gly 
                85                  90                  95      


Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu Tyr Lys Met Gly Phe 
            100                 105                 110         


Gly Phe Val Glu Ile Gly Ser Val Thr Pro Lys Pro Gln Glu Gly Asn 
        115                 120                 125             


Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp Gln Ala Val Ile Asn 
    130                 135                 140                 


Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val Val Glu His Arg Leu 
145                 150                 155                 160 


Arg Ala Arg Gln Gln Lys Gln Ala Lys Leu Thr Glu Asp Gly Leu Pro 
                165                 170                 175     


Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser Val Asp Ala Ala Glu 
            180                 185                 190         


Asp Tyr Ala Glu Gly Val Arg Val Leu Gly Pro Leu Ala Asp Tyr Leu 
        195                 200                 205             


Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln 
    210                 215                 220                 


Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys Val Leu Gln Glu Arg 
225                 230                 235                 240 


Asp Gly Leu Arg Arg Val His Arg Pro Ala Val Leu Val Lys Ile Ala 
                245                 250                 255     


Pro Asp Leu Thr Ser Gln Asp Lys Glu Asp Ile Ala Ser Val Val Lys 
            260                 265                 270         


Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn Thr Thr Val Ser Arg 
        275                 280                 285             


Pro Ala Gly Leu Gln Gly Ala Leu Arg Ser Glu Thr Gly Gly Leu Ser 
    290                 295                 300                 


Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr Ile Arg Glu Met Tyr 
305                 310                 315                 320 


Ala Leu Thr Gln Gly Arg Val Pro Ile Ile Gly Val Gly Gly Val Ser 
                325                 330                 335     


Ser Gly Gln Asp Ala Leu Glu Lys Ile Arg Ala Gly Ala Ser Leu Val 
            340                 345                 350         


Gln Leu Tyr Thr Ala Leu Thr Phe Trp Gly Pro Pro Val Val Gly Lys 
        355                 360                 365             


Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu Gln Gly Phe Gly Gly 
    370                 375                 380                 


Val Thr Asp Ala Ile Gly Ala Asp His Arg Arg 
385                 390                 395 


<210>  3049
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHPS__Homo_sapiens__NP_001193903

<400>  3049

Met Pro Ile Ile Pro Ala Phe Trp Glu Ala Glu Ala Gly Gly Ser Arg 
1               5                   10                  15      


Glu Glu Glu Phe Glu Thr Ser Leu Ala Asn Met Ile Glu Lys Lys Leu 
            20                  25                  30          


Glu Pro Leu Ser Gln Asp Glu Asp Gln His Ala Asp Leu Thr Gln Ser 
        35                  40                  45              


Arg Arg Pro Leu Thr Ser Cys Thr Ile Phe Leu Gly Tyr Thr Ser Asn 
    50                  55                  60                  


Leu Ile Ser Ser Gly Ile Arg Glu Thr Ile Arg Tyr Leu Val Gln His 
65                  70                  75                  80  


Asn Met Val Asp Val Leu Val Thr Thr Ala Gly Gly Val Glu Glu Asp 
                85                  90                  95      


Leu Ile Lys Cys Leu Ala Pro Thr Tyr Leu Gly Glu Phe Ser Leu Arg 
            100                 105                 110         


Gly Lys Glu Leu Arg Glu Asn Gly Ile Asn Arg Ile Gly Asn Leu Leu 
        115                 120                 125             


Val Pro Asn Glu Asn Tyr Cys Lys Phe Glu Asp Trp Leu Met Pro Ile 
    130                 135                 140                 


Leu Asp Gln Met Val Met Glu Gln Asn Thr Glu Gly Val Lys Trp Thr 
145                 150                 155                 160 


Pro Ser Lys Met Ile Ala Arg Leu Gly Lys Glu Ile Asn Asn Pro Glu 
                165                 170                 175     


Ser Val Tyr Tyr Trp Ala Gln Lys Asn His Ile Pro Val Phe Ser Pro 
            180                 185                 190         


Ala Leu Thr Asp Gly Ser Leu Gly Asp Met Ile Phe Phe His Ser Tyr 
        195                 200                 205             


Lys Asn Pro Gly Leu Val Leu Asp Ile Val Glu Asp Leu Arg Leu Ile 
    210                 215                 220                 


Asn Thr Gln Ala Ile Phe Ala Lys Cys Thr Gly Met Ile Ile Leu Gly 
225                 230                 235                 240 


Gly Gly Val Val Lys His His Ile Ala Asn Ala Asn Leu Met Arg Asn 
                245                 250                 255     


Gly Ala Asp Tyr Ala Val Tyr Ile Asn Thr Ala Gln Glu Phe Asp Gly 
            260                 265                 270         


Ser Asp Ser Gly Ala Arg Pro Asp Glu Ala Val Ser Trp Gly Lys Ile 
        275                 280                 285             


Arg Val Asp Ala Gln Pro Val Lys Val Tyr Ala Asp Ala Ser Leu Val 
    290                 295                 300                 


Phe Pro Leu Leu Val Ala Glu Thr Phe Ala Gln Lys Met Asp Ala Phe 
305                 310                 315                 320 


Met His Glu Lys Asn Glu Asp 
                325         


<210>  3050
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHRS11__Homo_sapiens__NP_077284

<400>  3050

Met Ala Arg Pro Gly Met Glu Arg Trp Arg Asp Arg Leu Ala Leu Val 
1               5                   10                  15      


Thr Gly Ala Ser Gly Gly Ile Gly Ala Ala Val Ala Arg Ala Leu Val 
            20                  25                  30          


Gln Gln Gly Leu Lys Val Val Gly Cys Ala Arg Thr Val Gly Asn Ile 
        35                  40                  45              


Glu Glu Leu Ala Ala Glu Cys Lys Ser Ala Gly Tyr Pro Gly Thr Leu 
    50                  55                  60                  


Ile Pro Tyr Arg Cys Asp Leu Ser Asn Glu Glu Asp Ile Leu Ser Met 
65                  70                  75                  80  


Phe Ser Ala Ile Arg Ser Gln His Ser Gly Val Asp Ile Cys Ile Asn 
                85                  90                  95      


Asn Ala Gly Leu Ala Arg Pro Asp Thr Leu Leu Ser Gly Ser Thr Ser 
            100                 105                 110         


Gly Trp Lys Asp Met Phe Asn Val Asn Val Leu Ala Leu Ser Ile Cys 
        115                 120                 125             


Thr Arg Glu Ala Tyr Gln Ser Met Lys Glu Arg Asn Val Asp Asp Gly 
    130                 135                 140                 


His Ile Ile Asn Ile Asn Ser Met Ser Gly His Arg Val Leu Pro Leu 
145                 150                 155                 160 


Ser Val Thr His Phe Tyr Ser Ala Thr Lys Tyr Ala Val Thr Ala Leu 
                165                 170                 175     


Thr Glu Gly Leu Arg Gln Glu Leu Arg Glu Ala Gln Thr His Ile Arg 
            180                 185                 190         


Ala Thr Cys Ile Ser Pro Gly Val Val Glu Thr Gln Phe Ala Phe Lys 
        195                 200                 205             


Leu His Asp Lys Asp Pro Glu Lys Ala Ala Ala Thr Tyr Glu Gln Met 
    210                 215                 220                 


Lys Cys Leu Lys Pro Glu Asp Val Ala Glu Ala Val Ile Tyr Val Leu 
225                 230                 235                 240 


Ser Thr Pro Ala His Ile Gln Ile Gly Asp Ile Gln Met Arg Pro Thr 
                245                 250                 255     


Glu Gln Val Thr 
            260 


<210>  3051
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHRS2__Homo_sapiens__NP_005785

<400>  3051

Met Leu Ser Ala Val Ala Arg Gly Tyr Gln Gly Trp Phe His Pro Cys 
1               5                   10                  15      


Ala Arg Leu Ser Val Arg Met Ser Ser Thr Gly Ile Asp Arg Lys Gly 
            20                  25                  30          


Val Leu Ala Asn Arg Val Ala Val Val Thr Gly Ser Thr Ser Gly Ile 
        35                  40                  45              


Gly Phe Ala Ile Ala Arg Arg Leu Ala Arg Asp Gly Ala His Val Val 
    50                  55                  60                  


Ile Ser Ser Arg Lys Gln Gln Asn Val Asp Arg Ala Met Ala Lys Leu 
65                  70                  75                  80  


Gln Gly Glu Gly Leu Ser Val Ala Gly Ile Val Cys His Val Gly Lys 
                85                  90                  95      


Ala Glu Asp Arg Glu Gln Leu Val Ala Lys Ala Leu Glu His Cys Gly 
            100                 105                 110         


Gly Val Asp Phe Leu Val Cys Ser Ala Gly Val Asn Pro Leu Val Gly 
        115                 120                 125             


Ser Thr Leu Gly Thr Ser Glu Gln Ile Trp Asp Lys Ile Leu Ser Val 
    130                 135                 140                 


Asn Val Lys Ser Pro Ala Leu Leu Leu Ser Gln Leu Leu Pro Tyr Met 
145                 150                 155                 160 


Glu Asn Arg Arg Gly Ala Val Ile Leu Val Ser Ser Ile Ala Ala Tyr 
                165                 170                 175     


Asn Pro Val Val Ala Leu Gly Val Tyr Asn Val Ser Lys Thr Ala Leu 
            180                 185                 190         


Leu Gly Leu Thr Arg Thr Leu Ala Leu Glu Leu Ala Pro Lys Asp Ile 
        195                 200                 205             


Arg Val Asn Cys Val Val Pro Gly Ile Ile Lys Thr Asp Phe Ser Lys 
    210                 215                 220                 


Val Phe His Gly Asn Glu Ser Leu Trp Lys Asn Phe Lys Glu His His 
225                 230                 235                 240 


Gln Leu Gln Arg Ile Gly Glu Ser Glu Asp Cys Ala Gly Ile Val Ser 
                245                 250                 255     


Phe Leu Cys Ser Pro Asp Ala Ser Tyr Val Asn Gly Glu Asn Ile Ala 
            260                 265                 270         


Val Ala Gly Tyr Ser Thr Arg Leu 
        275                 280 


<210>  3052
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHRS4__Homo_sapiens__NP_001269916

<400>  3052

Met His Lys Ala Gly Leu Leu Gly Leu Cys Ala Arg Ala Trp Asn Ser 
1               5                   10                  15      


Val Arg Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn 
            20                  25                  30          


Lys Val Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile 
        35                  40                  45              


Ala Arg Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg 
    50                  55                  60                  


Lys Gln Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly 
65                  70                  75                  80  


Leu Ser Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg 
                85                  90                  95      


Glu Arg Leu Val Ala Thr Ala Val Lys Leu His Gly Gly Ile Asp Ile 
            100                 105                 110         


Leu Val Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Ile Met Asp 
        115                 120                 125             


Val Thr Glu Glu Val Trp Asp Lys Arg Arg Leu Ser Gly Asp Arg Val 
    130                 135                 140                 


Phe His Ser Ser Leu Gln Ser Ile Ser Ser Leu Asp Gly Gln Gly Lys 
145                 150                 155                 160 


Arg Gly Lys His Glu Arg Asn Pro Ala Asp Lys Lys Val Arg Arg Ala 
                165                 170                 175     


Arg Gly Leu Cys Trp His Arg Val Phe Pro Val Leu 
            180                 185             


<210>  3053
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHRS7C__Homo_sapiens__NP_001099041

<400>  3053

Met Gly Val Met Ala Met Leu Met Leu Pro Leu Leu Leu Leu Gly Ile 
1               5                   10                  15      


Ser Gly Leu Leu Phe Ile Tyr Gln Glu Val Ser Arg Leu Trp Ser Lys 
            20                  25                  30          


Ser Ala Val Gln Asn Lys Val Val Val Ile Thr Asp Ala Ile Ser Gly 
        35                  40                  45              


Leu Gly Lys Glu Cys Ala Arg Val Phe His Thr Gly Gly Ala Arg Leu 
    50                  55                  60                  


Val Leu Cys Gly Lys Asn Trp Glu Arg Leu Glu Asn Leu Tyr Asp Ala 
65                  70                  75                  80  


Leu Ile Ser Val Ala Asp Pro Ser Lys Thr Phe Thr Pro Lys Leu Val 
                85                  90                  95      


Leu Leu Asp Leu Ser Asp Ile Ser Cys Val Pro Asp Val Ala Lys Glu 
            100                 105                 110         


Val Leu Asp Cys Tyr Gly Cys Val Asp Ile Leu Ile Asn Asn Ala Ser 
        115                 120                 125             


Val Lys Val Lys Gly Pro Ala His Lys Ile Ser Leu Glu Leu Asp Lys 
    130                 135                 140                 


Lys Ile Met Asp Ala Asn Tyr Phe Gly Pro Ile Thr Leu Thr Lys Ala 
145                 150                 155                 160 


Leu Leu Pro Asn Met Ile Ser Arg Arg Thr Gly Gln Ile Val Leu Val 
                165                 170                 175     


Asn Asn Ile Gln Gly Lys Phe Gly Ile Pro Phe Arg Thr Thr Tyr Ala 
            180                 185                 190         


Ala Ser Lys His Ala Ala Leu Gly Phe Phe Asp Cys Leu Arg Ala Glu 
        195                 200                 205             


Val Glu Glu Tyr Asp Val Val Ile Ser Thr Val Ser Pro Thr Phe Ile 
    210                 215                 220                 


Arg Ser Tyr His Val Tyr Pro Glu Gln Gly Asn Trp Glu Ala Ser Ile 
225                 230                 235                 240 


Trp Lys Phe Phe Phe Arg Lys Leu Thr Tyr Gly Val His Pro Val Glu 
                245                 250                 255     


Val Ala Glu Glu Val Met Arg Thr Val Arg Arg Lys Lys Gln Glu Val 
            260                 265                 270         


Phe Met Ala Asn Pro Ile Pro Lys Ala Ala Val Tyr Val Arg Thr Phe 
        275                 280                 285             


Phe Pro Glu Phe Phe Phe Ala Val Val Ala Cys Gly Val Lys Glu Lys 
    290                 295                 300                 


Leu Asn Val Pro Glu Glu Gly 
305                 310     


<210>  3054
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHRS9__Homo_sapiens__NP_001276692

<400>  3054

Met Pro Glu Gly Arg Ser His Cys Ala Cys Ser Ile Thr Ser Leu Thr 
1               5                   10                  15      


Leu Leu Val Ser Leu Thr Arg Val Thr Leu Asp Ile Leu Gln Lys Leu 
            20                  25                  30          


Asp Pro Pro Gln Pro Ala His Trp Arg His His Leu Leu Val Leu Tyr 
        35                  40                  45              


Lys Lys Gly Val Tyr Leu Ser His Thr Gly Gly Lys Met Leu Phe Trp 
    50                  55                  60                  


Val Leu Gly Leu Leu Ile Leu Cys Gly Phe Leu Trp Thr Arg Lys Gly 
65                  70                  75                  80  


Lys Leu Lys Ile Glu Asp Ile Thr Asp Lys Tyr Ile Phe Ile Thr Gly 
                85                  90                  95      


Cys Asp Ser Gly Phe Gly Asn Leu Ala Ala Arg Thr Phe Asp Lys Lys 
            100                 105                 110         


Gly Phe His Val Ile Ala Ala Cys Leu Thr Glu Ser Gly Ser Thr Ala 
        115                 120                 125             


Leu Lys Ala Glu Thr Ser Glu Arg Leu Arg Thr Val Leu Leu Asp Val 
    130                 135                 140                 


Thr Asp Pro Glu Asn Val Lys Arg Thr Ala Gln Trp Val Lys Asn Gln 
145                 150                 155                 160 


Val Gly Glu Lys Gly Leu Trp Gly Leu Ile Asn Asn Ala Gly Val Pro 
                165                 170                 175     


Gly Val Leu Ala Pro Thr Asp Trp Leu Thr Leu Glu Asp Tyr Arg Glu 
            180                 185                 190         


Pro Ile Glu Val Asn Leu Phe Gly Leu Ile Ser Val Thr Leu Asn Met 
        195                 200                 205             


Leu Pro Leu Val Lys Lys Ala Gln Gly Arg Val Ile Asn Val Ser Ser 
    210                 215                 220                 


Val Gly Gly Arg Leu Ala Ile Val Gly Gly Gly Tyr Thr Pro Ser Lys 
225                 230                 235                 240 


Tyr Ala Val Glu Gly Phe Asn Asp Ser Leu Arg Arg Asp Met Lys Ala 
                245                 250                 255     


Phe Gly Val His Val Ser Cys Ile Glu Pro Gly Leu Phe Lys Thr Asn 
            260                 265                 270         


Leu Ala Asp Pro Val Lys Val Ile Glu Lys Lys Leu Ala Ile Trp Glu 
        275                 280                 285             


Gln Leu Ser Pro Asp Ile Lys Gln Gln Tyr Gly Glu Gly Tyr Ile Glu 
    290                 295                 300                 


Lys Ser Leu Asp Lys Leu Lys Gly Asn Lys Ser Tyr Val Asn Met Asp 
305                 310                 315                 320 


Leu Ser Pro Val Val Glu Cys Met Asp His Ala Leu Thr Ser Leu Phe 
                325                 330                 335     


Pro Lys Thr His Tyr Ala Ala Gly Lys Asp Ala Lys Ile Phe Trp Ile 
            340                 345                 350         


Pro Leu Ser His Met Pro Ala Ala Leu Gln Asp Phe Leu Leu Leu Lys 
        355                 360                 365             


Gln Lys Ala Glu Leu Ala Asn Pro Lys Ala Val 
    370                 375                 


<210>  3055
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHTKD1__Homo_sapiens__NP_061176

<400>  3055

Met Ala Ser Ala Thr Ala Ala Ala Ala Arg Arg Gly Leu Gly Arg Ala 
1               5                   10                  15      


Leu Pro Leu Leu Trp Arg Gly Tyr Gln Thr Glu Arg Gly Val Tyr Gly 
            20                  25                  30          


Tyr Arg Pro Arg Lys Pro Glu Ser Arg Glu Pro Gln Gly Ala Leu Glu 
        35                  40                  45              


Arg Pro Pro Val Asp His Gly Leu Ala Arg Leu Val Thr Val Tyr Cys 
    50                  55                  60                  


Glu His Gly His Lys Ala Ala Lys Ile Asn Pro Leu Phe Thr Gly Gln 
65                  70                  75                  80  


Ala Leu Leu Glu Asn Val Pro Glu Ile Gln Ala Leu Val Gln Thr Leu 
                85                  90                  95      


Gln Gly Pro Phe His Thr Ala Gly Leu Leu Asn Met Gly Lys Glu Glu 
            100                 105                 110         


Ala Ser Leu Glu Glu Val Leu Val Tyr Leu Asn Gln Ile Tyr Cys Gly 
        115                 120                 125             


Gln Ile Ser Ile Glu Thr Ser Gln Leu Gln Ser Gln Asp Glu Lys Asp 
    130                 135                 140                 


Trp Phe Ala Lys Arg Phe Glu Glu Leu Gln Lys Glu Thr Phe Thr Thr 
145                 150                 155                 160 


Glu Glu Arg Lys His Leu Ser Lys Leu Met Leu Glu Ser Gln Glu Phe 
                165                 170                 175     


Asp His Phe Leu Ala Thr Lys Phe Ser Thr Val Lys Arg Tyr Gly Gly 
            180                 185                 190         


Glu Gly Ala Glu Ser Met Met Gly Phe Phe His Glu Leu Leu Lys Met 
        195                 200                 205             


Ser Ala Tyr Ser Gly Ile Thr Asp Val Ile Ile Gly Met Pro His Arg 
    210                 215                 220                 


Gly Arg Leu Asn Leu Leu Thr Gly Leu Leu Gln Phe Pro Pro Glu Leu 
225                 230                 235                 240 


Met Phe Arg Lys Met Arg Gly Leu Ser Glu Phe Pro Glu Asn Phe Ser 
                245                 250                 255     


Ala Thr Gly Asp Val Leu Ser His Leu Thr Ser Ser Val Asp Leu Tyr 
            260                 265                 270         


Phe Gly Ala His His Pro Leu His Val Thr Met Leu Pro Asn Pro Ser 
        275                 280                 285             


His Leu Glu Ala Val Asn Pro Val Ala Val Gly Lys Thr Arg Gly Arg 
    290                 295                 300                 


Gln Gln Ser Arg Gln Asp Gly Asp Tyr Ser Pro Asp Asn Ser Ala Gln 
305                 310                 315                 320 


Pro Gly Asp Arg Val Ile Cys Leu Gln Val His Gly Asp Ala Ser Phe 
                325                 330                 335     


Cys Gly Gln Gly Ile Val Pro Glu Thr Phe Thr Leu Ser Asn Leu Pro 
            340                 345                 350         


His Phe Arg Ile Gly Gly Ser Val His Leu Ile Val Asn Asn Gln Leu 
        355                 360                 365             


Gly Tyr Thr Thr Pro Ala Glu Arg Gly Arg Ser Ser Leu Tyr Cys Ser 
    370                 375                 380                 


Asp Ile Gly Lys Leu Val Gly Cys Ala Ile Ile His Val Asn Gly Asp 
385                 390                 395                 400 


Ser Pro Glu Glu Val Val Arg Ala Thr Arg Leu Ala Phe Glu Tyr Gln 
                405                 410                 415     


Arg Gln Phe Arg Lys Asp Val Ile Ile Asp Leu Leu Cys Tyr Arg Gln 
            420                 425                 430         


Trp Gly His Asn Glu Leu Asp Glu Pro Phe Tyr Thr Asn Pro Ile Met 
        435                 440                 445             


Tyr Lys Ile Ile Arg Ala Arg Lys Ser Ile Pro Asp Thr Tyr Ala Glu 
    450                 455                 460                 


His Leu Ile Ala Gly Gly Leu Met Thr Gln Glu Glu Val Ser Glu Ile 
465                 470                 475                 480 


Lys Ser Ser Tyr Tyr Ala Lys Leu Asn Asp His Leu Asn Asn Met Ala 
                485                 490                 495     


His Tyr Arg Pro Pro Ala Leu Asn Leu Gln Ala His Trp Gln Gly Leu 
            500                 505                 510         


Ala Gln Pro Glu Ala Gln Ile Thr Thr Trp Ser Thr Gly Val Pro Leu 
        515                 520                 525             


Asp Leu Leu Arg Phe Val Gly Met Lys Ser Val Glu Val Pro Arg Glu 
    530                 535                 540                 


Leu Gln Met His Ser His Leu Leu Lys Thr His Val Gln Ser Arg Met 
545                 550                 555                 560 


Glu Lys Met Met Asp Gly Ile Lys Leu Asp Trp Ala Thr Ala Glu Ala 
                565                 570                 575     


Leu Ala Leu Gly Ser Leu Leu Ala Gln Gly Phe Asn Val Arg Leu Ser 
            580                 585                 590         


Gly Gln Asp Val Gly Arg Gly Thr Phe Ser Gln Arg His Ala Ile Val 
        595                 600                 605             


Val Cys Gln Glu Thr Asp Asp Thr Tyr Ile Pro Leu Asn His Met Asp 
    610                 615                 620                 


Pro Asn Gln Lys Gly Phe Leu Glu Val Ser Asn Ser Pro Leu Ser Glu 
625                 630                 635                 640 


Glu Ala Val Leu Gly Phe Glu Tyr Gly Met Ser Ile Glu Ser Pro Lys 
                645                 650                 655     


Leu Leu Pro Leu Trp Glu Ala Gln Phe Gly Asp Phe Phe Asn Gly Ala 
            660                 665                 670         


Gln Ile Ile Phe Asp Thr Phe Ile Ser Gly Gly Glu Ala Lys Trp Leu 
        675                 680                 685             


Leu Gln Ser Gly Ile Val Ile Leu Leu Pro His Gly Tyr Asp Gly Ala 
    690                 695                 700                 


Gly Pro Asp His Ser Ser Cys Arg Ile Glu Arg Phe Leu Gln Met Cys 
705                 710                 715                 720 


Asp Ser Ala Glu Glu Gly Val Asp Gly Asp Thr Val Asn Met Phe Val 
                725                 730                 735     


Val His Pro Thr Thr Pro Ala Gln Tyr Phe His Leu Leu Arg Arg Gln 
            740                 745                 750         


Met Val Arg Asn Phe Arg Lys Pro Leu Ile Val Ala Ser Pro Lys Met 
        755                 760                 765             


Leu Leu Arg Leu Pro Ala Ala Val Ser Thr Leu Gln Glu Met Ala Pro 
    770                 775                 780                 


Gly Thr Thr Phe Asn Pro Val Ile Gly Asp Ser Ser Val Asp Pro Lys 
785                 790                 795                 800 


Lys Val Lys Thr Leu Val Phe Cys Ser Gly Lys His Phe Tyr Ser Leu 
                805                 810                 815     


Val Lys Gln Arg Glu Ser Leu Gly Ala Lys Lys His Asp Phe Ala Ile 
            820                 825                 830         


Ile Arg Val Glu Glu Leu Cys Pro Phe Pro Leu Asp Ser Leu Gln Gln 
        835                 840                 845             


Glu Met Ser Lys Tyr Lys His Val Lys Asp His Ile Trp Ser Gln Glu 
    850                 855                 860                 


Glu Pro Gln Asn Met Gly Pro Trp Ser Phe Val Ser Pro Arg Phe Glu 
865                 870                 875                 880 


Lys Gln Leu Ala Cys Lys Leu Arg Leu Val Gly Arg Pro Pro Leu Pro 
                885                 890                 895     


Val Pro Ala Val Gly Ile Gly Thr Val His Leu His Gln His Glu Asp 
            900                 905                 910         


Ile Leu Ala Lys Thr Phe Ala 
        915                 


<210>  3056
<211>  795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX15__Homo_sapiens__NP_001349

<400>  3056

Met Ser Lys Arg His Arg Leu Asp Leu Gly Glu Asp Tyr Pro Ser Gly 
1               5                   10                  15      


Lys Lys Arg Ala Gly Thr Asp Gly Lys Asp Arg Asp Arg Asp Arg Asp 
            20                  25                  30          


Arg Glu Asp Arg Ser Lys Asp Arg Asp Arg Glu Arg Asp Arg Gly Asp 
        35                  40                  45              


Arg Glu Arg Glu Arg Glu Lys Glu Lys Glu Lys Glu Leu Arg Ala Ser 
    50                  55                  60                  


Thr Asn Ala Met Leu Ile Ser Ala Gly Leu Pro Pro Leu Lys Ala Ser 
65                  70                  75                  80  


His Ser Ala His Ser Thr His Ser Ala His Ser Thr His Ser Thr His 
                85                  90                  95      


Ser Ala His Ser Thr His Ala Gly His Ala Gly His Thr Ser Leu Pro 
            100                 105                 110         


Gln Cys Ile Asn Pro Phe Thr Asn Leu Pro His Thr Pro Arg Tyr Tyr 
        115                 120                 125             


Asp Ile Leu Lys Lys Arg Leu Gln Leu Pro Val Trp Glu Tyr Lys Asp 
    130                 135                 140                 


Arg Phe Thr Asp Ile Leu Val Arg His Gln Ser Phe Val Leu Val Gly 
145                 150                 155                 160 


Glu Thr Gly Ser Gly Lys Thr Thr Gln Ile Pro Gln Trp Cys Val Glu 
                165                 170                 175     


Tyr Met Arg Ser Leu Pro Gly Pro Lys Arg Gly Val Ala Cys Thr Gln 
            180                 185                 190         


Pro Arg Arg Val Ala Ala Met Ser Val Ala Gln Arg Val Ala Asp Glu 
        195                 200                 205             


Met Asp Val Met Leu Gly Gln Glu Val Gly Tyr Ser Ile Arg Phe Glu 
    210                 215                 220                 


Asp Cys Ser Ser Ala Lys Thr Ile Leu Lys Tyr Met Thr Asp Gly Met 
225                 230                 235                 240 


Leu Leu Arg Glu Ala Met Asn Asp Pro Leu Leu Glu Arg Tyr Gly Val 
                245                 250                 255     


Ile Ile Leu Asp Glu Ala His Glu Arg Thr Leu Ala Thr Asp Ile Leu 
            260                 265                 270         


Met Gly Val Leu Lys Glu Val Val Arg Gln Arg Ser Asp Leu Lys Val 
        275                 280                 285             


Ile Val Met Ser Ala Thr Leu Asp Ala Gly Lys Phe Gln Ile Tyr Phe 
    290                 295                 300                 


Asp Asn Cys Pro Leu Leu Thr Ile Pro Gly Arg Thr His Pro Val Glu 
305                 310                 315                 320 


Ile Phe Tyr Thr Pro Glu Pro Glu Arg Asp Tyr Leu Glu Ala Ala Ile 
                325                 330                 335     


Arg Thr Val Ile Gln Ile His Met Cys Glu Glu Glu Glu Gly Asp Leu 
            340                 345                 350         


Leu Leu Phe Leu Thr Gly Gln Glu Glu Ile Asp Glu Ala Cys Lys Arg 
        355                 360                 365             


Ile Lys Arg Glu Val Asp Asp Leu Gly Pro Glu Val Gly Asp Ile Lys 
    370                 375                 380                 


Ile Ile Pro Leu Tyr Ser Thr Leu Pro Pro Gln Gln Gln Gln Arg Ile 
385                 390                 395                 400 


Phe Glu Pro Pro Pro Pro Lys Lys Gln Asn Gly Ala Ile Gly Arg Lys 
                405                 410                 415     


Val Val Val Ser Thr Asn Ile Ala Glu Thr Ser Leu Thr Ile Asp Gly 
            420                 425                 430         


Val Val Phe Val Ile Asp Pro Gly Phe Ala Lys Gln Lys Val Tyr Asn 
        435                 440                 445             


Pro Arg Ile Arg Val Glu Ser Leu Leu Val Thr Ala Ile Ser Lys Ala 
    450                 455                 460                 


Ser Ala Gln Gln Arg Ala Gly Arg Ala Gly Arg Thr Arg Pro Gly Lys 
465                 470                 475                 480 


Cys Phe Arg Leu Tyr Thr Glu Lys Ala Tyr Lys Thr Glu Met Gln Asp 
                485                 490                 495     


Asn Thr Tyr Pro Glu Ile Leu Arg Ser Asn Leu Gly Ser Val Val Leu 
            500                 505                 510         


Gln Leu Lys Lys Leu Gly Ile Asp Asp Leu Val His Phe Asp Phe Met 
        515                 520                 525             


Asp Pro Pro Ala Pro Glu Thr Leu Met Arg Ala Leu Glu Leu Leu Asn 
    530                 535                 540                 


Tyr Leu Ala Ala Leu Asn Asp Asp Gly Asp Leu Thr Glu Leu Gly Ser 
545                 550                 555                 560 


Met Met Ala Glu Phe Pro Leu Asp Pro Gln Leu Ala Lys Met Val Ile 
                565                 570                 575     


Ala Ser Cys Asp Tyr Asn Cys Ser Asn Glu Val Leu Ser Ile Thr Ala 
            580                 585                 590         


Met Leu Ser Val Pro Gln Cys Phe Val Arg Pro Thr Glu Ala Lys Lys 
        595                 600                 605             


Ala Ala Asp Glu Ala Lys Met Arg Phe Ala His Ile Asp Gly Asp His 
    610                 615                 620                 


Leu Thr Leu Leu Asn Val Tyr His Ala Phe Lys Gln Asn His Glu Ser 
625                 630                 635                 640 


Val Gln Trp Cys Tyr Asp Asn Phe Ile Asn Tyr Arg Ser Leu Met Ser 
                645                 650                 655     


Ala Asp Asn Val Arg Gln Gln Leu Ser Arg Ile Met Asp Arg Phe Asn 
            660                 665                 670         


Leu Pro Arg Arg Ser Thr Asp Phe Thr Ser Arg Asp Tyr Tyr Ile Asn 
        675                 680                 685             


Ile Arg Lys Ala Leu Val Thr Gly Tyr Phe Met Gln Val Ala His Leu 
    690                 695                 700                 


Glu Arg Thr Gly His Tyr Leu Thr Val Lys Asp Asn Gln Val Val Gln 
705                 710                 715                 720 


Leu His Pro Ser Thr Val Leu Asp His Lys Pro Glu Trp Val Leu Tyr 
                725                 730                 735     


Asn Glu Phe Val Leu Thr Thr Lys Asn Tyr Ile Arg Thr Cys Thr Asp 
            740                 745                 750         


Ile Lys Pro Glu Trp Leu Val Lys Ile Ala Pro Gln Tyr Tyr Asp Met 
        755                 760                 765             


Ser Asn Phe Pro Gln Cys Glu Ala Lys Arg Gln Leu Asp Arg Ile Ile 
    770                 775                 780                 


Ala Lys Leu Gln Ser Lys Glu Tyr Ser Gln Tyr 
785                 790                 795 


<210>  3057
<211>  981
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX16__Homo_sapiens__NP_001157711

<400>  3057

Met Ser Glu Asp Pro Arg Gly Pro Lys Val Pro Arg Lys Ala Val Val 
1               5                   10                  15      


Glu Lys Pro Ala Arg Ala Ala Glu Arg Glu Ala Arg Ala Leu Leu Glu 
            20                  25                  30          


Lys Asn Arg Ser Tyr Arg Leu Leu Glu Asp Ser Glu Glu Ser Ser Glu 
        35                  40                  45              


Glu Thr Val Ser Arg Ala Gly Ser Ser Leu Gln Lys Lys Arg Lys Lys 
    50                  55                  60                  


Arg Lys His Leu Arg Lys Lys Arg Glu Glu Glu Glu Glu Glu Glu Ala 
65                  70                  75                  80  


Ser Glu Lys Gly Lys Lys Lys Thr Gly Gly Ser Lys Gln Gln Thr Glu 
                85                  90                  95      


Lys Pro Glu Ser Glu Asp Glu Trp Glu Arg Thr Glu Arg Glu Arg Leu 
            100                 105                 110         


Gln Asp Leu Glu Glu Arg Asp Ala Phe Ala Glu Arg Val Arg Gln Arg 
        115                 120                 125             


Asp Lys Asp Arg Thr Arg Asn Val Leu Glu Arg Ser Asp Lys Lys Ala 
    130                 135                 140                 


Tyr Glu Glu Ala Gln Lys Arg Leu Lys Met Ala Glu Glu Asp Arg Lys 
145                 150                 155                 160 


Ala Met Val Pro Glu Leu Arg Lys Lys Ser Arg Arg Glu Tyr Leu Ala 
                165                 170                 175     


Lys Arg Glu Arg Glu Lys Leu Glu Asp Leu Glu Ala Glu Leu Ala Asp 
            180                 185                 190         


Glu Glu Phe Leu Phe Gly Asp Val Glu Leu Ser Arg His Glu Arg Gln 
        195                 200                 205             


Glu Leu Lys Tyr Lys Arg Arg Val Arg Asp Leu Ala Arg Glu Tyr Arg 
    210                 215                 220                 


Ala Ala Gly Glu Gln Glu Lys Leu Glu Ala Thr Asn Arg Tyr His Met 
225                 230                 235                 240 


Pro Lys Glu Thr Arg Gly Gln Pro Ala Arg Ala Val Asp Leu Val Glu 
                245                 250                 255     


Glu Glu Ser Gly Ala Pro Gly Glu Glu Gln Arg Arg Trp Glu Glu Ala 
            260                 265                 270         


Arg Leu Gly Ala Ala Ser Leu Lys Phe Gly Ala Arg Asp Ala Ala Ser 
        275                 280                 285             


Gln Glu Pro Lys Tyr Gln Leu Val Leu Glu Glu Glu Glu Thr Ile Glu 
    290                 295                 300                 


Phe Val Arg Ala Thr Gln Leu Gln Gly Asp Glu Glu Pro Ser Ala Pro 
305                 310                 315                 320 


Pro Thr Ser Thr Gln Ala Gln Gln Lys Glu Ser Ile Gln Ala Val Arg 
                325                 330                 335     


Arg Ser Leu Pro Val Phe Pro Phe Arg Glu Glu Leu Leu Ala Ala Ile 
            340                 345                 350         


Ala Asn His Gln Val Leu Ile Ile Glu Gly Glu Thr Gly Ser Gly Lys 
        355                 360                 365             


Thr Thr Gln Ile Pro Gln Tyr Leu Phe Glu Glu Gly Tyr Thr Asn Lys 
    370                 375                 380                 


Gly Met Lys Ile Ala Cys Thr Gln Pro Arg Arg Val Ala Ala Met Ser 
385                 390                 395                 400 


Val Ala Ala Arg Val Ala Arg Glu Met Gly Val Lys Leu Gly Asn Glu 
                405                 410                 415     


Val Gly Tyr Ser Ile Arg Phe Glu Asp Cys Thr Ser Glu Arg Thr Val 
            420                 425                 430         


Leu Arg Tyr Met Thr Asp Gly Met Leu Leu Arg Glu Phe Leu Ser Glu 
        435                 440                 445             


Pro Asp Leu Ala Ser Tyr Ser Val Val Met Val Asp Glu Ala His Glu 
    450                 455                 460                 


Arg Thr Leu His Thr Asp Ile Leu Phe Gly Leu Ile Lys Asp Val Ala 
465                 470                 475                 480 


Arg Phe Arg Pro Glu Leu Lys Val Leu Val Ala Ser Ala Thr Met Asp 
                485                 490                 495     


Thr Ala Arg Phe Ser Thr Phe Phe Asp Asp Ala Pro Val Phe Arg Ile 
            500                 505                 510         


Pro Gly Arg Arg Phe Pro Val Asp Ile Phe Tyr Thr Lys Ala Pro Glu 
        515                 520                 525             


Ala Asp Tyr Leu Glu Ala Cys Val Val Ser Val Leu Gln Ile His Val 
    530                 535                 540                 


Thr Gln Pro Pro Gly Asp Ile Leu Val Phe Leu Thr Gly Gln Glu Glu 
545                 550                 555                 560 


Ile Glu Ala Ala Cys Glu Met Leu Gln Asp Arg Cys Arg Arg Leu Gly 
                565                 570                 575     


Ser Lys Ile Arg Glu Leu Leu Val Leu Pro Ile Tyr Ala Asn Leu Pro 
            580                 585                 590         


Ser Asp Met Gln Ala Arg Ile Phe Gln Pro Thr Pro Pro Gly Ala Arg 
        595                 600                 605             


Lys Val Val Val Ala Thr Asn Ile Ala Glu Thr Ser Leu Thr Ile Glu 
    610                 615                 620                 


Gly Ile Ile Tyr Val Leu Asp Pro Gly Phe Cys Lys Gln Lys Ser Tyr 
625                 630                 635                 640 


Asn Pro Arg Thr Gly Met Glu Ser Leu Thr Val Thr Pro Cys Ser Lys 
                645                 650                 655     


Ala Ser Ala Asn Gln Arg Ala Gly Arg Ala Gly Arg Val Ala Ala Gly 
            660                 665                 670         


Lys Cys Phe Arg Leu Tyr Thr Ala Trp Ala Tyr Gln His Glu Leu Glu 
        675                 680                 685             


Glu Thr Thr Val Pro Glu Ile Gln Arg Thr Ser Leu Gly Asn Val Val 
    690                 695                 700                 


Leu Leu Leu Lys Ser Leu Gly Ile His Asp Leu Met His Phe Asp Phe 
705                 710                 715                 720 


Leu Asp Pro Pro Pro Tyr Glu Thr Leu Leu Leu Ala Leu Glu Gln Leu 
                725                 730                 735     


Tyr Ala Leu Gly Ala Leu Asn His Leu Gly Glu Leu Thr Thr Ser Gly 
            740                 745                 750         


Arg Lys Met Ala Glu Leu Pro Val Asp Pro Met Leu Ser Lys Met Ile 
        755                 760                 765             


Leu Ala Ser Glu Lys Tyr Ser Cys Ser Glu Glu Ile Leu Thr Val Ala 
    770                 775                 780                 


Ala Met Leu Ser Val Asn Asn Ser Ile Phe Tyr Arg Pro Lys Asp Lys 
785                 790                 795                 800 


Val Val His Ala Asp Asn Ala Arg Val Asn Phe Phe Leu Pro Gly Gly 
                805                 810                 815     


Asp His Leu Val Leu Leu Asn Val Tyr Thr Gln Trp Ala Glu Ser Gly 
            820                 825                 830         


Tyr Ser Ser Gln Trp Cys Tyr Glu Asn Phe Val Gln Phe Arg Ser Met 
        835                 840                 845             


Arg Arg Ala Arg Asp Val Arg Glu Gln Leu Glu Gly Leu Leu Glu Arg 
    850                 855                 860                 


Val Glu Val Gly Leu Ser Ser Cys Gln Gly Asp Tyr Ile Arg Val Arg 
865                 870                 875                 880 


Lys Ala Ile Thr Ala Gly Tyr Phe Tyr His Thr Ala Arg Leu Thr Arg 
                885                 890                 895     


Ser Gly Tyr Arg Thr Val Lys Gln Gln Gln Thr Val Phe Ile His Pro 
            900                 905                 910         


Asn Ser Ser Leu Phe Glu Gln Gln Pro Arg Trp Leu Leu Tyr His Glu 
        915                 920                 925             


Leu Val Leu Thr Thr Lys Glu Phe Met Arg Gln Val Leu Glu Ile Glu 
    930                 935                 940                 


Ser Ser Trp Leu Leu Glu Val Ala Pro His Tyr Tyr Lys Ala Lys Glu 
945                 950                 955                 960 


Leu Glu Asp Pro His Ala Lys Lys Met Pro Lys Lys Ile Gly Lys Thr 
                965                 970                 975     


Arg Glu Glu Leu Gly 
            980     


<210>  3058
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX32__Homo_sapiens__NP_060650

<400>  3058

Met Glu Glu Glu Gly Leu Glu Cys Pro Asn Ser Ser Ser Glu Lys Arg 
1               5                   10                  15      


Tyr Phe Pro Glu Ser Leu Asp Ser Ser Asp Gly Asp Glu Glu Glu Val 
            20                  25                  30          


Leu Ala Cys Glu Asp Leu Glu Leu Asn Pro Phe Asp Gly Leu Pro Tyr 
        35                  40                  45              


Ser Ser Arg Tyr Tyr Lys Leu Leu Lys Glu Arg Glu Asp Leu Pro Ile 
    50                  55                  60                  


Trp Lys Glu Lys Tyr Ser Phe Met Glu Asn Leu Leu Gln Asn Gln Ile 
65                  70                  75                  80  


Val Ile Val Ser Gly Asp Ala Lys Cys Gly Lys Ser Ala Gln Val Pro 
                85                  90                  95      


Gln Trp Cys Ala Glu Tyr Cys Leu Ser Ile His Tyr Gln His Gly Gly 
            100                 105                 110         


Val Ile Cys Thr Gln Val His Lys Gln Thr Val Val Gln Leu Ala Leu 
        115                 120                 125             


Arg Val Ala Asp Glu Met Asp Val Asn Ile Gly His Glu Val Gly Tyr 
    130                 135                 140                 


Val Ile Pro Phe Glu Asn Cys Cys Thr Asn Glu Thr Ile Leu Arg Tyr 
145                 150                 155                 160 


Cys Thr Asp Asp Met Leu Gln Arg Glu Met Met Ser Asn Pro Phe Leu 
                165                 170                 175     


Gly Ser Tyr Gly Val Ile Ile Leu Asp Asp Ile His Glu Arg Ser Ile 
            180                 185                 190         


Ala Thr Asp Val Leu Leu Gly Leu Leu Lys Asp Val Leu Leu Ala Arg 
        195                 200                 205             


Pro Glu Leu Lys Leu Ile Ile Asn Ser Ser Pro His Leu Ile Ser Lys 
    210                 215                 220                 


Leu Asn Ser Tyr Tyr Gly Asn Val Pro Val Ile Glu Val Lys Asn Lys 
225                 230                 235                 240 


His Pro Val Glu Val Val Tyr Leu Ser Glu Ala Gln Lys Asp Ser Phe 
                245                 250                 255     


Glu Ser Ile Leu Arg Leu Ile Phe Glu Ile His His Ser Gly Glu Lys 
            260                 265                 270         


Gly Asp Ile Val Val Phe Leu Ala Cys Glu Gln Asp Ile Glu Lys Val 
        275                 280                 285             


Cys Glu Thr Val Tyr Gln Gly Ser Asn Leu Asn Pro Asp Leu Gly Glu 
    290                 295                 300                 


Leu Val Val Val Pro Leu Tyr Pro Lys Glu Lys Cys Ser Leu Phe Lys 
305                 310                 315                 320 


Pro Leu Asp Glu Thr Glu Lys Arg Cys Gln Val Tyr Gln Arg Arg Val 
                325                 330                 335     


Val Leu Thr Thr Ser Ser Gly Glu Phe Leu Ile Trp Ser Asn Ser Val 
            340                 345                 350         


Arg Phe Val Ile Asp Val Gly Val Glu Arg Arg Lys Val Tyr Asn Pro 
        355                 360                 365             


Arg Ile Arg Ala Asn Ser Leu Val Met Gln Pro Ile Ser Gln Ser Gln 
    370                 375                 380                 


Ala Glu Ile Arg Lys Gln Ile Leu Gly Ser Ser Ser Ser Gly Lys Phe 
385                 390                 395                 400 


Phe Cys Leu Tyr Thr Glu Glu Phe Ala Ser Lys Asp Met Thr Pro Leu 
                405                 410                 415     


Lys Pro Ala Glu Met Gln Glu Ala Asn Leu Thr Ser Met Val Leu Phe 
            420                 425                 430         


Met Lys Arg Ile Asp Ile Ala Gly Leu Gly His Cys Asp Phe Met Asn 
        435                 440                 445             


Arg Pro Ala Pro Glu Ser Leu Met Gln Ala Leu Glu Asp Leu Asp Tyr 
    450                 455                 460                 


Leu Ala Ala Leu Asp Asn Asp Gly Asn Leu Ser Glu Phe Gly Ile Ile 
465                 470                 475                 480 


Met Ser Glu Phe Pro Leu Asp Pro Gln Leu Ser Lys Ser Ile Leu Ala 
                485                 490                 495     


Ser Cys Glu Phe Asp Cys Val Asp Glu Val Leu Thr Ile Ala Ala Met 
            500                 505                 510         


Val Thr Ala Pro Asn Cys Phe Ser His Val Pro His Gly Ala Glu Glu 
        515                 520                 525             


Ala Ala Leu Thr Cys Trp Lys Thr Phe Leu His Pro Glu Gly Asp His 
    530                 535                 540                 


Phe Thr Leu Ile Ser Ile Tyr Lys Ala Tyr Gln Asp Thr Thr Leu Asn 
545                 550                 555                 560 


Ser Ser Ser Glu Tyr Cys Val Glu Lys Trp Cys Arg Asp Tyr Phe Leu 
                565                 570                 575     


Asn Cys Ser Ala Leu Arg Met Ala Asp Val Ile Arg Ala Glu Leu Leu 
            580                 585                 590         


Glu Ile Ile Lys Arg Ile Glu Leu Pro Tyr Ala Glu Pro Ala Phe Gly 
        595                 600                 605             


Ser Lys Glu Asn Thr Leu Asn Ile Lys Lys Ala Leu Leu Ser Gly Tyr 
    610                 615                 620                 


Phe Met Gln Ile Ala Arg Asp Val Asp Gly Ser Gly Asn Tyr Leu Met 
625                 630                 635                 640 


Leu Thr His Lys Gln Val Ala Gln Leu His Pro Leu Ser Gly Tyr Ser 
                645                 650                 655     


Ile Thr Lys Lys Met Pro Glu Trp Val Leu Phe His Lys Phe Ser Ile 
            660                 665                 670         


Ser Glu Asn Asn Tyr Ile Arg Ile Thr Ser Glu Ile Ser Pro Glu Leu 
        675                 680                 685             


Phe Met Gln Leu Val Pro Gln Tyr Tyr Phe Ser Asn Leu Pro Pro Ser 
    690                 695                 700                 


Glu Ser Lys Asp Ile Leu Gln Gln Val Val Asp His Leu Ser Pro Val 
705                 710                 715                 720 


Ser Thr Met Asn Lys Glu Gln Gln Met Cys Glu Thr Cys Pro Glu Thr 
                725                 730                 735     


Glu Gln Arg Cys Thr Leu Gln 
            740             


<210>  3059
<211>  1143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX34__Homo_sapiens__NP_055496

<400>  3059

Met Pro Pro Pro Arg Thr Arg Glu Gly Arg Asp Arg Arg Asp His His 
1               5                   10                  15      


Arg Ala Pro Ser Glu Glu Glu Ala Leu Glu Lys Trp Asp Trp Asn Cys 
            20                  25                  30          


Pro Glu Thr Arg Arg Leu Leu Glu Asp Ala Phe Phe Arg Glu Glu Asp 
        35                  40                  45              


Tyr Ile Arg Gln Gly Ser Glu Glu Cys Gln Lys Phe Trp Thr Phe Phe 
    50                  55                  60                  


Glu Arg Leu Gln Arg Phe Gln Asn Leu Lys Thr Ser Arg Lys Glu Glu 
65                  70                  75                  80  


Lys Asp Pro Gly Gln Pro Lys His Ser Ile Pro Ala Leu Ala Asp Leu 
                85                  90                  95      


Pro Arg Thr Tyr Asp Pro Arg Tyr Arg Ile Asn Leu Ser Val Leu Gly 
            100                 105                 110         


Pro Ala Thr Arg Gly Ser Gln Gly Leu Gly Arg His Leu Pro Ala Glu 
        115                 120                 125             


Arg Val Ala Glu Phe Arg Arg Ala Leu Leu His Tyr Leu Asp Phe Gly 
    130                 135                 140                 


Gln Lys Gln Ala Phe Gly Arg Leu Ala Lys Leu Gln Arg Glu Arg Ala 
145                 150                 155                 160 


Ala Leu Pro Ile Ala Gln Tyr Gly Asn Arg Ile Leu Gln Thr Leu Lys 
                165                 170                 175     


Glu His Gln Val Val Val Val Ala Gly Asp Thr Gly Cys Gly Lys Ser 
            180                 185                 190         


Thr Gln Val Pro Gln Tyr Leu Leu Ala Ala Gly Phe Ser His Val Ala 
        195                 200                 205             


Cys Thr Gln Pro Arg Arg Ile Ala Cys Ile Ser Leu Ala Lys Arg Val 
    210                 215                 220                 


Gly Phe Glu Ser Leu Ser Gln Tyr Gly Ser Gln Val Gly Tyr Gln Ile 
225                 230                 235                 240 


Arg Phe Glu Ser Thr Arg Ser Ala Ala Thr Lys Ile Val Phe Leu Thr 
                245                 250                 255     


Val Gly Leu Leu Leu Arg Gln Ile Gln Arg Glu Pro Ser Leu Pro Gln 
            260                 265                 270         


Tyr Glu Val Leu Ile Val Asp Glu Val His Glu Arg His Leu His Asn 
        275                 280                 285             


Asp Phe Leu Leu Gly Val Leu Gln Arg Leu Leu Pro Thr Arg Pro Asp 
    290                 295                 300                 


Leu Lys Val Ile Leu Met Ser Ala Thr Ile Asn Ile Ser Leu Phe Ser 
305                 310                 315                 320 


Ser Tyr Phe Ser Asn Ala Pro Val Val Gln Val Pro Gly Arg Leu Phe 
                325                 330                 335     


Pro Ile Thr Val Val Tyr Gln Pro Gln Glu Ala Glu Pro Thr Thr Ser 
            340                 345                 350         


Lys Ser Glu Lys Leu Asp Pro Arg Pro Phe Leu Arg Val Leu Glu Ser 
        355                 360                 365             


Ile Asp His Lys Tyr Pro Pro Glu Glu Arg Gly Asp Leu Leu Val Phe 
    370                 375                 380                 


Leu Ser Gly Met Ala Glu Ile Ser Ala Val Leu Glu Ala Ala Gln Thr 
385                 390                 395                 400 


Tyr Ala Ser His Thr Gln Arg Trp Val Val Leu Pro Leu His Ser Ala 
                405                 410                 415     


Leu Ser Val Ala Asp Gln Asp Lys Val Phe Asp Val Ala Pro Pro Gly 
            420                 425                 430         


Val Arg Lys Cys Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Val Thr 
        435                 440                 445             


Ile Asp Gly Ile Arg Phe Val Val Asp Ser Gly Lys Val Lys Glu Met 
    450                 455                 460                 


Ser Tyr Asp Pro Gln Ala Lys Leu Gln Arg Leu Gln Glu Phe Trp Ile 
465                 470                 475                 480 


Ser Gln Ala Ser Ala Glu Gln Arg Lys Gly Arg Ala Gly Arg Thr Gly 
                485                 490                 495     


Pro Gly Val Cys Phe Arg Leu Tyr Ala Glu Ser Asp Tyr Asp Ala Phe 
            500                 505                 510         


Ala Pro Tyr Pro Val Pro Glu Ile Arg Arg Val Ala Leu Asp Ser Leu 
        515                 520                 525             


Val Leu Gln Met Lys Ser Met Ser Val Gly Asp Pro Arg Thr Phe Pro 
    530                 535                 540                 


Phe Ile Glu Pro Pro Pro Pro Ala Ser Leu Glu Thr Ala Ile Leu Tyr 
545                 550                 555                 560 


Leu Arg Asp Gln Gly Ala Leu Asp Ser Ser Glu Ala Leu Thr Pro Ile 
                565                 570                 575     


Gly Ser Leu Leu Ala Gln Leu Pro Val Asp Val Val Ile Gly Lys Met 
            580                 585                 590         


Leu Ile Leu Gly Ser Met Phe Ser Leu Val Glu Pro Val Leu Thr Ile 
        595                 600                 605             


Ala Ala Ala Leu Ser Val Gln Ser Pro Phe Thr Arg Ser Ala Gln Ser 
    610                 615                 620                 


Ser Pro Glu Cys Ala Ala Ala Arg Arg Pro Leu Glu Ser Asp Gln Gly 
625                 630                 635                 640 


Asp Pro Phe Thr Leu Phe Asn Val Phe Asn Ala Trp Val Gln Val Lys 
                645                 650                 655     


Ser Glu Arg Ser Arg Asn Ser Arg Lys Trp Cys Arg Arg Arg Gly Ile 
            660                 665                 670         


Glu Glu His Arg Leu Tyr Glu Met Ala Asn Leu Arg Arg Gln Phe Lys 
        675                 680                 685             


Glu Leu Leu Glu Asp His Gly Leu Leu Ala Gly Ala Gln Ala Ala Gln 
    690                 695                 700                 


Val Gly Asp Ser Tyr Ser Arg Leu Gln Gln Arg Arg Glu Arg Arg Ala 
705                 710                 715                 720 


Leu His Gln Leu Lys Arg Gln His Glu Glu Gly Ala Gly Arg Arg Arg 
                725                 730                 735     


Lys Val Leu Arg Leu Gln Glu Glu Gln Asp Gly Gly Ser Ser Asp Glu 
            740                 745                 750         


Asp Arg Ala Gly Pro Ala Pro Pro Gly Ala Ser Asp Gly Val Asp Ile 
        755                 760                 765             


Gln Asp Val Lys Phe Lys Leu Arg His Asp Leu Ala Gln Leu Gln Ala 
    770                 775                 780                 


Ala Ala Ser Ser Ala Gln Asp Leu Ser Arg Glu Gln Leu Ala Leu Leu 
785                 790                 795                 800 


Lys Leu Val Leu Gly Arg Gly Leu Tyr Pro Gln Leu Ala Val Pro Asp 
                805                 810                 815     


Ala Phe Asn Ser Ser Arg Lys Asp Ser Asp Gln Ile Phe His Thr Gln 
            820                 825                 830         


Ala Lys Gln Gly Ala Val Leu His Pro Thr Cys Val Phe Ala Gly Ser 
        835                 840                 845             


Pro Glu Val Leu His Ala Gln Glu Leu Glu Ala Ser Asn Cys Asp Gly 
    850                 855                 860                 


Ser Arg Asp Asp Lys Asp Lys Met Ser Ser Lys His Gln Leu Leu Ser 
865                 870                 875                 880 


Phe Val Ser Leu Leu Glu Thr Asn Lys Pro Tyr Leu Val Asn Cys Val 
                885                 890                 895     


Arg Ile Pro Ala Leu Gln Ser Leu Leu Leu Phe Ser Arg Ser Leu Asp 
            900                 905                 910         


Thr Asn Gly Asp Cys Ser Arg Leu Val Ala Asp Gly Trp Leu Glu Leu 
        915                 920                 925             


Gln Leu Ala Asp Ser Glu Ser Ala Ile Arg Leu Leu Ala Ala Ser Leu 
    930                 935                 940                 


Arg Leu Arg Ala Arg Trp Glu Ser Ala Leu Asp Arg Gln Leu Ala His 
945                 950                 955                 960 


Gln Ala Gln Gln Gln Leu Glu Glu Glu Glu Glu Asp Thr Pro Val Ser 
                965                 970                 975     


Pro Lys Glu Val Ala Thr Leu Ser Lys Glu Leu Leu Gln Phe Thr Ala 
            980                 985                 990         


Ser Lys Ile Pro Tyr Ser Leu Arg  Arg Leu Thr Gly Leu  Glu Val Gln 
        995                 1000                 1005             


Asn Met  Tyr Val Gly Pro Gln  Thr Ile Pro Ala Thr  Pro His Leu 
    1010                 1015                 1020             


Pro Gly  Leu Phe Gly Ser Ser  Thr Leu Ser Pro His  Pro Thr Lys 
    1025                 1030                 1035             


Gly Gly  Tyr Ala Val Thr Asp  Phe Leu Thr Tyr Asn  Cys Leu Thr 
    1040                 1045                 1050             


Asn Asp  Thr Asp Leu Tyr Ser  Asp Cys Leu Arg Thr  Phe Trp Thr 
    1055                 1060                 1065             


Cys Pro  His Cys Gly Leu His  Ala Pro Leu Thr Pro  Leu Glu Arg 
    1070                 1075                 1080             


Ile Ala  His Glu Asn Thr Cys  Pro Gln Ala Pro Gln  Asp Gly Pro 
    1085                 1090                 1095             


Pro Gly  Ala Glu Glu Ala Ala  Leu Glu Thr Leu Gln  Lys Thr Ser 
    1100                 1105                 1110             


Val Leu  Gln Arg Pro Tyr His  Cys Glu Ala Cys Gly  Lys Asp Phe 
    1115                 1120                 1125             


Leu Phe  Thr Pro Thr Glu Val  Leu Arg His Arg Lys  Gln His Val 
    1130                 1135                 1140             


<210>  3060
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX36__Homo_sapiens__NP_001107869

<400>  3060

Met Ser Tyr Asp Tyr His Gln Asn Trp Gly Arg Asp Gly Gly Pro Arg 
1               5                   10                  15      


Ser Ser Gly Gly Gly Tyr Gly Gly Gly Pro Ala Gly Gly His Gly Gly 
            20                  25                  30          


Asn Arg Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Gly 
        35                  40                  45              


Gly Arg Gly Arg His Pro Gly His Leu Lys Gly Arg Glu Ile Gly Met 
    50                  55                  60                  


Trp Tyr Ala Lys Lys Gln Gly Gln Lys Asn Lys Glu Ala Glu Arg Gln 
65                  70                  75                  80  


Glu Arg Ala Val Val His Met Asp Glu Arg Arg Glu Glu Gln Ile Val 
                85                  90                  95      


Gln Leu Leu Asn Ser Val Gln Ala Lys Asn Asp Lys Glu Ser Glu Ala 
            100                 105                 110         


Gln Ile Ser Trp Phe Ala Pro Glu Asp His Gly Tyr Gly Thr Glu Val 
        115                 120                 125             


Ser Thr Lys Asn Thr Pro Cys Ser Glu Asn Lys Leu Asp Ile Gln Glu 
    130                 135                 140                 


Lys Lys Leu Ile Asn Gln Glu Lys Lys Met Phe Arg Ile Arg Asn Arg 
145                 150                 155                 160 


Ser Tyr Ile Asp Arg Asp Ser Glu Tyr Leu Leu Gln Glu Asn Glu Pro 
                165                 170                 175     


Asp Gly Thr Leu Asp Gln Lys Leu Leu Glu Asp Leu Gln Lys Lys Lys 
            180                 185                 190         


Asn Asp Leu Arg Tyr Ile Glu Met Gln His Phe Arg Glu Lys Leu Pro 
        195                 200                 205             


Ser Tyr Gly Met Gln Lys Glu Leu Val Asn Leu Ile Asp Asn His Gln 
    210                 215                 220                 


Val Thr Val Ile Ser Gly Glu Thr Gly Cys Gly Lys Thr Thr Gln Val 
225                 230                 235                 240 


Thr Gln Phe Ile Leu Asp Asn Tyr Ile Glu Arg Gly Lys Gly Ser Ala 
                245                 250                 255     


Cys Arg Ile Val Cys Thr Gln Pro Arg Arg Ile Ser Ala Ile Ser Val 
            260                 265                 270         


Ala Glu Arg Val Ala Ala Glu Arg Ala Glu Ser Cys Gly Ser Gly Asn 
        275                 280                 285             


Ser Thr Gly Tyr Gln Ile Arg Leu Gln Ser Arg Leu Pro Arg Lys Gln 
    290                 295                 300                 


Gly Ser Ile Leu Tyr Cys Thr Thr Gly Ile Ile Leu Gln Trp Leu Gln 
305                 310                 315                 320 


Ser Asp Pro Tyr Leu Ser Ser Val Ser His Ile Val Leu Asp Glu Ile 
                325                 330                 335     


His Glu Arg Asn Leu Gln Ser Asp Val Leu Met Thr Val Val Lys Asp 
            340                 345                 350         


Leu Leu Asn Phe Arg Ser Asp Leu Lys Val Ile Leu Met Ser Ala Thr 
        355                 360                 365             


Leu Asn Ala Glu Lys Phe Ser Glu Tyr Phe Gly Asn Cys Pro Met Ile 
    370                 375                 380                 


His Ile Pro Gly Phe Thr Phe Pro Val Val Glu Tyr Leu Leu Glu Asp 
385                 390                 395                 400 


Val Ile Glu Lys Ile Arg Tyr Val Pro Glu Gln Lys Glu His Arg Ser 
                405                 410                 415     


Gln Phe Lys Arg Gly Phe Met Gln Gly His Val Asn Arg Gln Glu Lys 
            420                 425                 430         


Glu Glu Lys Glu Ala Ile Tyr Lys Glu Arg Trp Pro Asp Tyr Val Arg 
        435                 440                 445             


Glu Leu Arg Arg Arg Tyr Ser Ala Ser Thr Val Asp Val Ile Glu Met 
    450                 455                 460                 


Met Glu Asp Asp Lys Val Asp Leu Asn Leu Ile Val Ala Leu Ile Arg 
465                 470                 475                 480 


Tyr Ile Val Leu Glu Glu Glu Asp Gly Ala Ile Leu Val Phe Leu Pro 
                485                 490                 495     


Gly Trp Asp Asn Ile Ser Thr Leu His Asp Leu Leu Met Ser Gln Val 
            500                 505                 510         


Met Phe Lys Ser Val Asn Gln Thr Gln Val Phe Lys Arg Thr Pro Pro 
        515                 520                 525             


Gly Val Arg Lys Ile Val Ile Ala Thr Asn Ile Ala Glu Thr Ser Ile 
    530                 535                 540                 


Thr Ile Asp Asp Val Val Tyr Val Ile Asp Gly Gly Lys Ile Lys Glu 
545                 550                 555                 560 


Thr His Phe Asp Thr Gln Asn Asn Ile Ser Thr Met Ser Ala Glu Trp 
                565                 570                 575     


Val Ser Lys Ala Asn Ala Lys Gln Arg Lys Gly Arg Ala Gly Arg Val 
            580                 585                 590         


Gln Pro Gly His Cys Tyr His Leu Tyr Asn Gly Leu Arg Ala Ser Leu 
        595                 600                 605             


Leu Asp Asp Tyr Gln Leu Pro Glu Ile Leu Arg Thr Pro Leu Glu Glu 
    610                 615                 620                 


Leu Cys Leu Gln Ile Lys Ile Leu Arg Leu Gly Gly Ile Ala Tyr Phe 
625                 630                 635                 640 


Leu Ser Arg Leu Met Asp Pro Pro Ser Asn Glu Ala Val Leu Leu Ser 
                645                 650                 655     


Ile Arg His Leu Met Glu Leu Asn Ala Leu Asp Lys Gln Glu Glu Leu 
            660                 665                 670         


Thr Pro Leu Gly Val His Leu Ala Arg Leu Pro Val Glu Pro His Ile 
        675                 680                 685             


Gly Lys Met Ile Leu Phe Gly Ala Leu Phe Cys Cys Leu Asp Pro Val 
    690                 695                 700                 


Leu Thr Ile Ala Ala Ser Leu Ser Phe Lys Asp Pro Phe Val Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Glu Lys Ile Ala Asp Ala Arg Arg Lys Glu Leu Ala Lys 
                725                 730                 735     


Asp Thr Arg Ser Asp His Leu Thr Val Val Asn Ala Phe Glu Gly Trp 
            740                 745                 750         


Glu Glu Ala Arg Arg Arg Gly Phe Arg Tyr Glu Lys Asp Tyr Cys Trp 
        755                 760                 765             


Glu Tyr Phe Leu Ser Ser Asn Thr Leu Gln Met Leu His Asn Met Lys 
    770                 775                 780                 


Gly Gln Phe Ala Glu His Leu Leu Gly Ala Gly Phe Val Ser Ser Arg 
785                 790                 795                 800 


Asn Pro Lys Asp Pro Glu Ser Asn Ile Asn Ser Asp Asn Glu Lys Ile 
                805                 810                 815     


Ile Lys Ala Val Ile Cys Ala Gly Leu Tyr Pro Lys Val Ala Lys Ile 
            820                 825                 830         


Arg Leu Asn Leu Gly Lys Lys Arg Lys Met Val Lys Val Tyr Thr Lys 
        835                 840                 845             


Thr Asp Gly Leu Val Ala Val His Pro Lys Ser Val Asn Val Glu Gln 
    850                 855                 860                 


Thr Asp Phe His Tyr Asn Trp Leu Ile Tyr His Leu Lys Met Arg Thr 
865                 870                 875                 880 


Ser Ser Ile Tyr Leu Tyr Asp Cys Thr Glu Val Ser Pro Tyr Cys Leu 
                885                 890                 895     


Leu Phe Phe Gly Gly Asp Ile Ser Ile Gln Lys Asp Asn Asp Gln Glu 
            900                 905                 910         


Thr Ile Ala Val Asp Glu Trp Ile Val Phe Gln Ser Pro Ala Arg Ile 
        915                 920                 925             


Ala His Leu Val Lys Glu Leu Arg Lys Glu Leu Asp Ile Leu Leu Gln 
    930                 935                 940                 


Glu Lys Ile Glu Ser Pro His Pro Val Asp Trp Asn Asp Thr Lys Ser 
945                 950                 955                 960 


Arg Asp Cys Ala Val Leu Ser Ala Ile Ile Asp Leu Ile Lys Thr Gln 
                965                 970                 975     


Glu Lys Ala Thr Pro Arg Asn Phe Pro Pro Arg Phe Gln Asp Gly Tyr 
            980                 985                 990         


Tyr Ser 
        


<210>  3061
<211>  1227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX38__Homo_sapiens__NP_054722

<400>  3061

Met Gly Asp Thr Ser Glu Asp Ala Ser Ile His Arg Leu Glu Gly Thr 
1               5                   10                  15      


Asp Leu Asp Cys Gln Val Gly Gly Leu Ile Cys Lys Ser Lys Ser Ala 
            20                  25                  30          


Ala Ser Glu Gln His Val Phe Lys Ala Pro Ala Pro Arg Pro Ser Leu 
        35                  40                  45              


Leu Gly Leu Asp Leu Leu Ala Ser Leu Lys Arg Arg Glu Arg Glu Glu 
    50                  55                  60                  


Lys Asp Asp Gly Glu Asp Lys Lys Lys Ser Lys Val Ser Ser Tyr Lys 
65                  70                  75                  80  


Asp Trp Glu Glu Ser Lys Asp Asp Gln Lys Asp Ala Glu Glu Glu Gly 
                85                  90                  95      


Gly Asp Gln Ala Gly Gln Asn Ile Arg Lys Asp Arg His Tyr Arg Ser 
            100                 105                 110         


Ala Arg Val Glu Thr Pro Ser His Pro Gly Gly Val Ser Glu Glu Phe 
        115                 120                 125             


Trp Glu Arg Ser Arg Gln Arg Glu Arg Glu Arg Arg Glu His Gly Val 
    130                 135                 140                 


Tyr Ala Ser Ser Lys Glu Glu Lys Asp Trp Lys Lys Glu Lys Ser Arg 
145                 150                 155                 160 


Asp Arg Asp Tyr Asp Arg Lys Arg Asp Arg Asp Glu Arg Asp Arg Ser 
                165                 170                 175     


Arg His Ser Ser Arg Ser Glu Arg Asp Gly Gly Ser Glu Arg Ser Ser 
            180                 185                 190         


Arg Arg Asn Glu Pro Glu Ser Pro Arg His Arg Pro Lys Asp Ala Ala 
        195                 200                 205             


Thr Pro Ser Arg Ser Thr Trp Glu Glu Glu Asp Ser Gly Tyr Gly Ser 
    210                 215                 220                 


Ser Arg Arg Ser Gln Trp Glu Ser Pro Ser Pro Thr Pro Ser Tyr Arg 
225                 230                 235                 240 


Asp Ser Glu Arg Ser His Arg Leu Ser Thr Arg Asp Arg Asp Arg Ser 
                245                 250                 255     


Val Arg Gly Lys Tyr Ser Asp Asp Thr Pro Leu Pro Thr Pro Ser Tyr 
            260                 265                 270         


Lys Tyr Asn Glu Trp Ala Asp Asp Arg Arg His Leu Gly Ser Thr Pro 
        275                 280                 285             


Arg Leu Ser Arg Gly Arg Gly Arg Arg Glu Glu Gly Glu Glu Gly Ile 
    290                 295                 300                 


Ser Phe Asp Thr Glu Glu Glu Arg Gln Gln Trp Glu Asp Asp Gln Arg 
305                 310                 315                 320 


Gln Ala Asp Arg Asp Trp Tyr Met Met Asp Glu Gly Tyr Asp Glu Phe 
                325                 330                 335     


His Asn Pro Leu Ala Tyr Ser Ser Glu Asp Tyr Val Arg Arg Arg Glu 
            340                 345                 350         


Gln His Leu His Lys Gln Lys Gln Lys Arg Ile Ser Ala Gln Arg Arg 
        355                 360                 365             


Gln Ile Asn Glu Asp Asn Glu Arg Trp Glu Thr Asn Arg Met Leu Thr 
    370                 375                 380                 


Ser Gly Val Val His Arg Leu Glu Val Asp Glu Asp Phe Glu Glu Asp 
385                 390                 395                 400 


Asn Ala Ala Lys Val His Leu Met Val His Asn Leu Val Pro Pro Phe 
                405                 410                 415     


Leu Asp Gly Arg Ile Val Phe Thr Lys Gln Pro Glu Pro Val Ile Pro 
            420                 425                 430         


Val Lys Asp Ala Thr Ser Asp Leu Ala Ile Ile Ala Arg Lys Gly Ser 
        435                 440                 445             


Gln Thr Val Arg Lys His Arg Glu Gln Lys Glu Arg Lys Lys Ala Gln 
    450                 455                 460                 


His Lys His Trp Glu Leu Ala Gly Thr Lys Leu Gly Asp Ile Met Gly 
465                 470                 475                 480 


Val Lys Lys Glu Glu Glu Pro Asp Lys Ala Val Thr Glu Asp Gly Lys 
                485                 490                 495     


Val Asp Tyr Arg Thr Glu Gln Lys Phe Ala Asp His Met Lys Arg Lys 
            500                 505                 510         


Ser Glu Ala Ser Ser Glu Phe Ala Lys Lys Lys Ser Ile Leu Glu Gln 
        515                 520                 525             


Arg Gln Tyr Leu Pro Ile Phe Ala Val Gln Gln Glu Leu Leu Thr Ile 
    530                 535                 540                 


Ile Arg Asp Asn Ser Ile Val Ile Val Val Gly Glu Thr Gly Ser Gly 
545                 550                 555                 560 


Lys Thr Thr Gln Leu Thr Gln Tyr Leu His Glu Asp Gly Tyr Thr Asp 
                565                 570                 575     


Tyr Gly Met Ile Gly Cys Thr Gln Pro Arg Arg Val Ala Ala Met Ser 
            580                 585                 590         


Val Ala Lys Arg Val Ser Glu Glu Met Gly Gly Asn Leu Gly Glu Glu 
        595                 600                 605             


Val Gly Tyr Ala Ile Arg Phe Glu Asp Cys Thr Ser Glu Asn Thr Leu 
    610                 615                 620                 


Ile Lys Tyr Met Thr Asp Gly Ile Leu Leu Arg Glu Ser Leu Arg Glu 
625                 630                 635                 640 


Ala Asp Leu Asp His Tyr Ser Ala Ile Ile Met Asp Glu Ala His Glu 
                645                 650                 655     


Arg Ser Leu Asn Thr Asp Val Leu Phe Gly Leu Leu Arg Glu Val Val 
            660                 665                 670         


Ala Arg Arg Ser Asp Leu Lys Leu Ile Val Thr Ser Ala Thr Met Asp 
        675                 680                 685             


Ala Glu Lys Phe Ala Ala Phe Phe Gly Asn Val Pro Ile Phe His Ile 
    690                 695                 700                 


Pro Gly Arg Thr Phe Pro Val Asp Ile Leu Phe Ser Lys Thr Pro Gln 
705                 710                 715                 720 


Glu Asp Tyr Val Glu Ala Ala Val Lys Gln Ser Leu Gln Val His Leu 
                725                 730                 735     


Ser Gly Ala Pro Gly Asp Ile Leu Ile Phe Met Pro Gly Gln Glu Asp 
            740                 745                 750         


Ile Glu Val Thr Ser Asp Gln Ile Val Glu His Leu Glu Glu Leu Glu 
        755                 760                 765             


Asn Ala Pro Ala Leu Ala Val Leu Pro Ile Tyr Ser Gln Leu Pro Ser 
    770                 775                 780                 


Asp Leu Gln Ala Lys Ile Phe Gln Lys Ala Pro Asp Gly Val Arg Lys 
785                 790                 795                 800 


Cys Ile Val Ala Thr Asn Ile Ala Glu Thr Ser Leu Thr Val Asp Gly 
                805                 810                 815     


Ile Met Phe Val Ile Asp Ser Gly Tyr Cys Lys Leu Lys Val Phe Asn 
            820                 825                 830         


Pro Arg Ile Gly Met Asp Ala Leu Gln Ile Tyr Pro Ile Ser Gln Ala 
        835                 840                 845             


Asn Ala Asn Gln Arg Ser Gly Arg Ala Gly Arg Thr Gly Pro Gly Gln 
    850                 855                 860                 


Cys Phe Arg Leu Tyr Thr Gln Ser Ala Tyr Lys Asn Glu Leu Leu Thr 
865                 870                 875                 880 


Thr Thr Val Pro Glu Ile Gln Arg Thr Asn Leu Ala Asn Val Val Leu 
                885                 890                 895     


Leu Leu Lys Ser Leu Gly Val Gln Asp Leu Leu Gln Phe His Phe Met 
            900                 905                 910         


Asp Pro Pro Pro Glu Asp Asn Met Leu Asn Ser Met Tyr Gln Leu Trp 
        915                 920                 925             


Ile Leu Gly Ala Leu Asp Asn Thr Gly Gly Leu Thr Ser Thr Gly Arg 
    930                 935                 940                 


Leu Met Val Glu Phe Pro Leu Asp Pro Ala Leu Ser Lys Met Leu Ile 
945                 950                 955                 960 


Val Ser Cys Asp Met Gly Cys Ser Ser Glu Ile Leu Leu Ile Val Ser 
                965                 970                 975     


Met Leu Ser Val Pro Ala Ile Phe Tyr Arg Pro Lys Gly Arg Glu Glu 
            980                 985                 990         


Glu Ser Asp Gln Ile Arg Glu Lys  Phe Ala Val Pro Glu  Ser Asp His 
        995                 1000                 1005             


Leu Thr  Tyr Leu Asn Val Tyr  Leu Gln Trp Lys Asn  Asn Asn Tyr 
    1010                 1015                 1020             


Ser Thr  Ile Trp Cys Asn Asp  His Phe Ile His Ala  Lys Ala Met 
    1025                 1030                 1035             


Arg Lys  Val Arg Glu Val Arg  Ala Gln Leu Lys Asp  Ile Met Val 
    1040                 1045                 1050             


Gln Gln  Arg Met Ser Leu Ala  Ser Cys Gly Thr Asp  Trp Asp Ile 
    1055                 1060                 1065             


Val Arg  Lys Cys Ile Cys Ala  Ala Tyr Phe His Gln  Ala Ala Lys 
    1070                 1075                 1080             


Leu Lys  Gly Ile Gly Glu Tyr  Val Asn Ile Arg Thr  Gly Met Pro 
    1085                 1090                 1095             


Cys His  Leu His Pro Thr Ser  Ser Leu Phe Gly Met  Gly Tyr Thr 
    1100                 1105                 1110             


Pro Asp  Tyr Ile Val Tyr His  Glu Leu Val Met Thr  Thr Lys Glu 
    1115                 1120                 1125             


Tyr Met  Gln Cys Val Thr Ala  Val Asp Gly Glu Trp  Leu Ala Glu 
    1130                 1135                 1140             


Leu Gly  Pro Met Phe Tyr Ser  Val Lys Gln Ala Gly  Lys Ser Arg 
    1145                 1150                 1155             


Gln Glu  Asn Arg Arg Arg Ala  Lys Glu Glu Ala Ser  Ala Met Glu 
    1160                 1165                 1170             


Glu Glu  Met Ala Leu Ala Glu  Glu Gln Leu Arg Ala  Arg Arg Gln 
    1175                 1180                 1185             


Glu Gln  Glu Lys Arg Ser Pro  Leu Gly Ser Val Arg  Ser Thr Lys 
    1190                 1195                 1200             


Ile Tyr  Thr Pro Gly Arg Lys  Glu Gln Gly Glu Pro  Met Thr Pro 
    1205                 1210                 1215             


Arg Arg  Thr Pro Ala Arg Phe  Gly Leu 
    1220                 1225         


<210>  3062
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX40__Homo_sapiens__NP_001159773

<400>  3062

Met Ser Arg Phe Pro Ala Val Ala Gly Arg Ala Pro Arg Arg Gln Glu 
1               5                   10                  15      


Glu Gly Glu Arg Ser Arg Asp Leu Gln Glu Glu Arg Leu Ser Ala Val 
            20                  25                  30          


Cys Ile Ala Asp Arg Glu Glu Lys Gly Cys Thr Ser Gln Glu Gly Gly 
        35                  40                  45              


Thr Thr Pro Thr Phe Pro Ile Gln Lys Gln Arg Lys Lys Ile Ile Gln 
    50                  55                  60                  


Ala Glu Thr Ala Ile Lys Tyr Met Thr Asp Gly Cys Leu Leu Lys His 
65                  70                  75                  80  


Ile Leu Gly Asp Pro Asn Leu Thr Lys Phe Ser Val Ile Ile Leu Asp 
                85                  90                  95      


Glu Ala His Glu Arg Thr Leu Thr Thr Asp Ile Leu Phe Gly Leu Leu 
            100                 105                 110         


Lys Lys Leu Phe Gln Glu Lys Ser Pro Asn Arg Lys Glu His Leu Lys 
        115                 120                 125             


Val Val Val Met Ser Ala Thr Met Glu Leu Ala Lys Leu Ser Ala Phe 
    130                 135                 140                 


Phe Gly Asn Cys Pro Ile Phe Asp Ile Pro Gly Arg Leu Tyr Pro Val 
145                 150                 155                 160 


Arg Glu Lys Phe Cys Asn Leu Ile Gly Pro Arg Asp Arg Glu Asn Thr 
                165                 170                 175     


Ala Tyr Ile Gln Ala Ile Val Lys Val Thr Met Asp Ile His Leu Asn 
            180                 185                 190         


Glu Met Ala Gly Asp Ile Leu Val Phe Leu Thr Gly Gln Phe Glu Ile 
        195                 200                 205             


Glu Lys Ser Cys Glu Leu Leu Phe Gln Met Ala Glu Ser Val Asp Tyr 
    210                 215                 220                 


Asp Tyr Asp Val Gln Asp Thr Thr Leu Asp Gly Leu Leu Ile Leu Pro 
225                 230                 235                 240 


Cys Tyr Gly Ser Met Thr Thr Asp Gln Gln Arg Arg Ile Phe Leu Pro 
                245                 250                 255     


Pro Pro Pro Gly Ile Arg Lys Cys Val Ile Ser Thr Asn Ile Ser Ala 
            260                 265                 270         


Thr Ser Leu Thr Ile Asp Gly Ile Arg Tyr Val Val Asp Gly Gly Phe 
        275                 280                 285             


Val Lys Gln Leu Asn His Asn Pro Arg Leu Gly Leu Asp Ile Leu Glu 
    290                 295                 300                 


Val Val Pro Ile Ser Lys Ser Glu Ala Leu Gln Arg Ser Gly Arg Ala 
305                 310                 315                 320 


Gly Arg Thr Ser Ser Gly Lys Cys Phe Arg Ile Tyr Ser Lys Asp Phe 
                325                 330                 335     


Trp Asn Gln Cys Met Pro Asp His Val Ile Pro Glu Ile Lys Arg Thr 
            340                 345                 350         


Ser Leu Thr Ser Val Val Leu Thr Leu Lys Cys Leu Ala Ile His Asp 
        355                 360                 365             


Val Ile Arg Phe Pro Tyr Leu Asp Pro Pro Asn Glu Arg Leu Ile Leu 
    370                 375                 380                 


Glu Ala Leu Lys Gln Leu Tyr Gln Cys Asp Ala Ile Asp Arg Ser Gly 
385                 390                 395                 400 


His Val Thr Arg Leu Gly Leu Ser Met Val Glu Phe Pro Leu Pro Pro 
                405                 410                 415     


His Leu Thr Cys Ala Val Ile Lys Ala Ala Ser Leu Asp Cys Glu Asp 
            420                 425                 430         


Leu Leu Leu Pro Ile Ala Ala Met Leu Ser Val Glu Asn Val Phe Ile 
        435                 440                 445             


Arg Pro Val Asp Pro Glu Tyr Gln Lys Glu Ala Glu Gln Arg His Arg 
    450                 455                 460                 


Glu Leu Ala Ala Lys Ala Gly Gly Phe Asn Asp Phe Ala Thr Leu Ala 
465                 470                 475                 480 


Val Ile Phe Glu Gln Cys Lys Ser Ser Gly Ala Pro Ala Ser Trp Cys 
                485                 490                 495     


Gln Lys His Trp Ile His Trp Arg Cys Leu Phe Ser Ala Phe Arg Val 
            500                 505                 510         


Glu Ala Gln Leu Arg Glu Leu Ile Arg Lys Leu Lys Gln Gln Ser Asp 
        515                 520                 525             


Phe Pro Lys Glu Thr Phe Glu Gly Pro Lys His Glu Val Leu Arg Arg 
    530                 535                 540                 


Cys Leu Cys Ala Gly Tyr Phe Lys Asn Val Ala Arg Arg Ser Val Gly 
545                 550                 555                 560 


Arg Thr Phe Cys Thr Met Asp Gly Arg Gly Ser Pro Val His Ile His 
                565                 570                 575     


Pro Ser Ser Ala Leu His Glu Gln Glu Thr Lys Leu Glu Trp Ile Ile 
            580                 585                 590         


Phe His Glu Val Leu Val Thr Thr Lys Val Tyr Ala Arg Ile Val Cys 
        595                 600                 605             


Pro Ile Arg Tyr Glu Trp Val Arg Asp Leu Leu Pro Lys Leu His Glu 
    610                 615                 620                 


Phe Asn Ala His Asp Leu Ser Ser Val Ala Arg Arg Glu Val Arg Glu 
625                 630                 635                 640 


Asp Ala Arg Arg Arg Trp Thr Asn Lys Glu Asn Val Lys Gln Leu Lys 
                645                 650                 655     


Asp Gly Ile Ser Lys Asp Val Leu Lys Lys Met Gln Arg Arg Asn Asp 
            660                 665                 670         


Asp Lys Ser Ile Ser Asp Ala Arg Ala Arg Phe Leu Glu Arg Lys Gln 
        675                 680                 685             


Gln Arg Thr Gln Asp His Ser Asp Thr Arg Lys Glu Thr Gly 
    690                 695                 700         


<210>  3063
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX58__Homo_sapiens__NP_077024

<400>  3063

Met Glu Leu Arg Ser Tyr Gln Trp Glu Val Ile Met Pro Ala Leu Glu 
1               5                   10                  15      


Gly Lys Asn Ile Ile Ile Trp Leu Pro Thr Gly Ala Gly Lys Thr Arg 
            20                  25                  30          


Ala Ala Ala Tyr Val Ala Lys Arg His Leu Glu Thr Val Asp Gly Ala 
        35                  40                  45              


Lys Val Val Val Leu Val Asn Arg Val His Leu Val Thr Gln His Gly 
    50                  55                  60                  


Glu Glu Phe Arg Arg Met Leu Asp Gly Arg Trp Thr Val Thr Thr Leu 
65                  70                  75                  80  


Ser Gly Asp Met Gly Pro Arg Ala Gly Phe Gly His Leu Ala Arg Cys 
                85                  90                  95      


His Asp Leu Leu Ile Cys Thr Ala Glu Leu Leu Gln Met Ala Leu Thr 
            100                 105                 110         


Ser Pro Glu Glu Glu Glu His Val Glu Leu Thr Val Phe Ser Leu Ile 
        115                 120                 125             


Val Val Asp Glu Cys His His Thr His Lys Asp Thr Val Tyr Asn Val 
    130                 135                 140                 


Ile Met Ser Gln Tyr Leu Glu Leu Lys Leu Gln Arg Ala Gln Pro Leu 
145                 150                 155                 160 


Pro Gln Val Leu Gly Leu Thr Ala Ser Pro Gly Thr Gly Gly Ala Ser 
                165                 170                 175     


Lys Leu Asp Gly Ala Ile Asn His Val Leu Gln Leu Cys Ala Asn Leu 
            180                 185                 190         


Asp Thr Trp Cys Ile Met Ser Pro Gln Asn Cys Cys Pro Gln Leu Gln 
        195                 200                 205             


Glu His Ser Gln Gln Pro Cys Lys Gln Tyr Asn Leu Cys His Arg Arg 
    210                 215                 220                 


Ser Gln Asp Pro Phe Gly Asp Leu Leu Lys Lys Leu Met Asp Gln Ile 
225                 230                 235                 240 


His Asp His Leu Glu Met Pro Glu Leu Ser Arg Lys Phe Gly Thr Gln 
                245                 250                 255     


Met Tyr Glu Gln Gln Val Val Lys Leu Ser Glu Ala Ala Ala Leu Ala 
            260                 265                 270         


Gly Leu Gln Glu Gln Arg Val Tyr Ala Leu His Leu Arg Arg Tyr Asn 
        275                 280                 285             


Asp Ala Leu Leu Ile His Asp Thr Val Arg Ala Val Asp Ala Leu Ala 
    290                 295                 300                 


Ala Leu Gln Asp Phe Tyr His Arg Glu His Val Thr Lys Thr Gln Ile 
305                 310                 315                 320 


Leu Cys Ala Glu Arg Arg Leu Leu Ala Leu Phe Asp Asp Arg Lys Asn 
                325                 330                 335     


Glu Leu Ala His Leu Ala Thr His Gly Pro Glu Asn Pro Lys Leu Glu 
            340                 345                 350         


Met Leu Glu Lys Ile Leu Gln Arg Gln Phe Ser Ser Ser Asn Ser Pro 
        355                 360                 365             


Arg Gly Ile Ile Phe Thr Arg Thr Arg Gln Ser Ala His Ser Leu Leu 
    370                 375                 380                 


Leu Trp Leu Gln Gln Gln Gln Gly Leu Gln Thr Val Asp Ile Arg Ala 
385                 390                 395                 400 


Gln Leu Leu Ile Gly Ala Gly Asn Ser Ser Gln Ser Thr His Met Thr 
                405                 410                 415     


Gln Arg Asp Gln Gln Glu Val Ile Gln Lys Phe Gln Asp Gly Thr Leu 
            420                 425                 430         


Asn Leu Leu Val Ala Thr Ser Val Ala Glu Glu Gly Leu Asp Ile Pro 
        435                 440                 445             


His Cys Asn Val Val Val Arg Tyr Gly Leu Leu Thr Asn Glu Ile Ser 
    450                 455                 460                 


Met Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Gln Ser Val Tyr Ala 
465                 470                 475                 480 


Phe Val Ala Thr Glu Gly Ser Arg Glu Leu Lys Arg Glu Leu Ile Asn 
                485                 490                 495     


Glu Ala Leu Glu Thr Leu Met Glu Gln Ala Val Ala Ala Val Gln Lys 
            500                 505                 510         


Met Asp Gln Ala Glu Tyr Gln Ala Lys Ile Arg Asp Leu Gln Gln Ala 
        515                 520                 525             


Ala Leu Thr Lys Arg Ala Ala Gln Ala Ala Gln Arg Glu Asn Gln Arg 
    530                 535                 540                 


Gln Gln Phe Pro Val Glu His Val Gln Leu Leu Cys Ile Asn Cys Met 
545                 550                 555                 560 


Val Ala Val Gly His Gly Ser Asp Leu Arg Lys Val Glu Gly Thr His 
                565                 570                 575     


His Val Asn Val Asn Pro Asn Phe Ser Asn Tyr Tyr Asn Val Ser Arg 
            580                 585                 590         


Asp Pro Val Val Ile Asn Lys Val Phe Lys Asp Trp Lys Pro Gly Gly 
        595                 600                 605             


Val Ile Ser Cys Arg Asn Cys Gly Glu Val Trp Gly Leu Gln Met Ile 
    610                 615                 620                 


Tyr Lys Ser Val Lys Leu Pro Val Leu Lys Val Arg Ser Met Leu Leu 
625                 630                 635                 640 


Glu Thr Pro Gln Gly Arg Ile Gln Ala Lys Lys Trp Ser Arg Val Pro 
                645                 650                 655     


Phe Ser Val Pro Asp Phe Asp Phe Leu Gln His Cys Ala Glu Asn Leu 
            660                 665                 670         


Ser Asp Leu Ser Leu Asp 
        675             


<210>  3064
<211>  1181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX8__Homo_sapiens__NP_001289552

<400>  3064

Met Ala Val Ala Val Ala Met Ala Gly Ala Leu Ile Gly Ser Glu Pro 
1               5                   10                  15      


Gly Pro Ala Glu Glu Leu Ala Lys Leu Glu Tyr Leu Ser Leu Val Ser 
            20                  25                  30          


Lys Val Cys Thr Glu Leu Asp Asn His Leu Gly Ile Asn Asp Lys Asp 
        35                  40                  45              


Leu Ala Glu Phe Val Ile Ser Leu Ala Glu Lys Asn Thr Thr Phe Asp 
    50                  55                  60                  


Thr Phe Lys Ala Ser Leu Val Lys Asn Gly Ala Glu Phe Thr Asp Ser 
65                  70                  75                  80  


Leu Ile Ser Asn Leu Leu Arg Leu Ile Gln Thr Met Arg Pro Pro Ala 
                85                  90                  95      


Lys Pro Ser Thr Ser Lys Asp Pro Val Val Lys Pro Lys Thr Glu Lys 
            100                 105                 110         


Glu Lys Leu Lys Glu Leu Phe Pro Val Leu Cys Gln Pro Asp Asn Pro 
        115                 120                 125             


Ser Val Arg Thr Met Leu Asp Glu Asp Asp Val Lys Val Ala Val Asp 
    130                 135                 140                 


Val Leu Lys Glu Leu Glu Ala Leu Met Pro Ser Ala Ala Gly Gln Glu 
145                 150                 155                 160 


Lys Gln Arg Asp Ala Glu His Arg Asp Arg Thr Lys Lys Lys Lys Arg 
                165                 170                 175     


Ser Arg Ser Arg Asp Arg Asn Arg Asp Arg Asp Arg Asp Arg Glu Arg 
            180                 185                 190         


Asn Arg Asp Arg Asp His Lys Arg Arg His Arg Ser Arg Ser Arg Ser 
        195                 200                 205             


Arg Ser Arg Thr Arg Glu Arg Asn Lys Val Lys Ser Arg Tyr Arg Ser 
    210                 215                 220                 


Arg Ser Arg Ser Gln Ser Pro Pro Lys Asp Arg Lys Asp Arg Asp Lys 
225                 230                 235                 240 


Tyr Gly Glu Arg Asn Leu Asp Arg Trp Arg Asp Lys His Val Asp Arg 
                245                 250                 255     


Pro Pro Pro Glu Glu Pro Thr Ile Gly Asp Ile Tyr Asn Gly Lys Val 
            260                 265                 270         


Thr Ser Ile Met Gln Phe Gly Cys Phe Val Gln Leu Glu Gly Leu Arg 
        275                 280                 285             


Lys Arg Trp Glu Gly Leu Val His Ile Ser Glu Leu Arg Arg Glu Gly 
    290                 295                 300                 


Arg Val Ala Asn Val Ala Asp Val Val Ser Lys Gly Gln Arg Val Lys 
305                 310                 315                 320 


Val Lys Val Leu Ser Phe Thr Gly Thr Lys Thr Ser Leu Ser Met Lys 
                325                 330                 335     


Asp Val Asp Gln Glu Thr Gly Glu Asp Leu Asn Pro Asn Arg Arg Arg 
            340                 345                 350         


Asn Leu Val Gly Glu Thr Asn Glu Glu Thr Ser Met Arg Asn Pro Asp 
        355                 360                 365             


Arg Pro Thr His Leu Ser Leu Val Ser Ala Pro Glu Val Glu Asp Asp 
    370                 375                 380                 


Ser Leu Glu Arg Lys Arg Leu Thr Arg Ile Ser Asp Pro Glu Lys Trp 
385                 390                 395                 400 


Glu Ile Lys Gln Met Ile Ala Ala Asn Val Leu Ser Lys Glu Glu Phe 
                405                 410                 415     


Pro Asp Phe Asp Glu Glu Thr Gly Ile Leu Pro Lys Val Asp Asp Glu 
            420                 425                 430         


Glu Asp Glu Asp Leu Glu Ile Glu Leu Val Glu Glu Glu Pro Pro Phe 
        435                 440                 445             


Leu Arg Gly His Thr Lys Gln Ser Met Asp Met Ser Pro Ile Lys Ile 
    450                 455                 460                 


Val Lys Asn Pro Asp Gly Ser Leu Ser Gln Ala Ala Met Met Gln Ser 
465                 470                 475                 480 


Ala Leu Ala Lys Glu Arg Arg Glu Leu Lys Gln Ala Gln Arg Glu Ala 
                485                 490                 495     


Glu Met Asp Ser Ile Pro Met Gly Leu Asn Lys His Trp Val Asp Pro 
            500                 505                 510         


Leu Pro Asp Ala Glu Gly Arg Gln Ile Ala Ala Asn Met Arg Gly Ile 
        515                 520                 525             


Gly Met Met Pro Asn Asp Ile Pro Glu Trp Lys Lys His Ala Phe Gly 
    530                 535                 540                 


Gly Asn Lys Ala Ser Tyr Gly Lys Lys Thr Gln Met Ser Ile Leu Glu 
545                 550                 555                 560 


Gln Arg Glu Ser Leu Pro Ile Tyr Lys Leu Lys Glu Gln Leu Val Gln 
                565                 570                 575     


Ala Val His Asp Asn Gln Ile Leu Ile Val Ile Gly Glu Thr Gly Ser 
            580                 585                 590         


Gly Lys Thr Thr Gln Ile Thr Gln Tyr Leu Ala Glu Ala Gly Tyr Thr 
        595                 600                 605             


Ser Arg Gly Lys Ile Gly Cys Thr Gln Pro Arg Arg Val Ala Ala Met 
    610                 615                 620                 


Ser Val Ala Lys Arg Val Ser Glu Glu Phe Gly Cys Cys Leu Gly Gln 
625                 630                 635                 640 


Glu Val Gly Tyr Thr Ile Arg Phe Glu Asp Cys Thr Ser Pro Glu Thr 
                645                 650                 655     


Val Ile Lys Tyr Met Thr Asp Gly Met Leu Leu Arg Glu Cys Leu Ile 
            660                 665                 670         


Asp Pro Asp Leu Thr Gln Tyr Ala Ile Ile Met Leu Asp Glu Ala His 
        675                 680                 685             


Glu Arg Thr Ile His Thr Asp Val Leu Phe Gly Leu Leu Lys Lys Thr 
    690                 695                 700                 


Val Gln Lys Arg Gln Asp Met Lys Leu Ile Val Thr Ser Ala Thr Leu 
705                 710                 715                 720 


Asp Ala Val Lys Phe Ser Gln Tyr Phe Tyr Glu Ala Pro Ile Phe Thr 
                725                 730                 735     


Ile Pro Gly Arg Thr Tyr Pro Val Glu Ile Leu Tyr Thr Lys Glu Pro 
            740                 745                 750         


Glu Thr Asp Tyr Leu Asp Ala Ser Leu Ile Thr Val Met Gln Ile His 
        755                 760                 765             


Leu Thr Glu Pro Pro Gly Asp Ile Leu Val Phe Leu Thr Gly Gln Glu 
    770                 775                 780                 


Glu Ile Asp Thr Ala Cys Glu Ile Leu Tyr Glu Arg Met Lys Ser Leu 
785                 790                 795                 800 


Gly Pro Asp Val Pro Glu Leu Ile Ile Leu Pro Val Tyr Ser Ala Leu 
                805                 810                 815     


Pro Ser Glu Met Gln Thr Arg Ile Phe Asp Pro Ala Pro Pro Gly Ser 
            820                 825                 830         


Arg Lys Val Val Ile Ala Thr Asn Ile Ala Glu Thr Ser Leu Thr Ile 
        835                 840                 845             


Asp Gly Ile Tyr Tyr Val Val Asp Pro Gly Phe Val Lys Gln Lys Val 
    850                 855                 860                 


Tyr Asn Ser Lys Thr Gly Ile Asp Gln Leu Val Val Thr Pro Ile Ser 
865                 870                 875                 880 


Gln Ala Gln Ala Lys Gln Arg Ala Gly Arg Ala Gly Arg Thr Gly Pro 
                885                 890                 895     


Gly Lys Cys Tyr Arg Leu Tyr Thr Glu Arg Ala Tyr Arg Asp Glu Met 
            900                 905                 910         


Leu Thr Thr Asn Val Pro Glu Ile Gln Arg Thr Asn Leu Ala Ser Thr 
        915                 920                 925             


Val Leu Ser Leu Lys Ala Met Gly Ile Asn Asp Leu Leu Ser Phe Asp 
    930                 935                 940                 


Phe Met Asp Ala Pro Pro Met Glu Thr Leu Ile Thr Ala Met Glu Gln 
945                 950                 955                 960 


Leu Tyr Thr Leu Gly Ala Leu Asp Asp Glu Gly Leu Leu Thr Arg Leu 
                965                 970                 975     


Gly Arg Arg Met Ala Glu Phe Pro Leu Glu Pro Met Leu Cys Lys Met 
            980                 985                 990         


Leu Ile Met Ser Val His Leu Gly  Cys Ser Glu Glu Met  Leu Thr Ile 
        995                 1000                 1005             


Val Ser  Met Leu Ser Val Gln  Asn Val Phe Tyr Arg  Pro Lys Asp 
    1010                 1015                 1020             


Lys Gln  Ala Leu Ala Asp Gln  Lys Lys Ala Lys Phe  His Gln Thr 
    1025                 1030                 1035             


Glu Gly  Asp His Leu Thr Leu  Leu Ala Val Tyr Asn  Ser Trp Lys 
    1040                 1045                 1050             


Asn Asn  Lys Phe Ser Asn Pro  Trp Cys Tyr Glu Asn  Phe Ile Gln 
    1055                 1060                 1065             


Ala Arg  Ser Leu Arg Arg Ala  Gln Asp Ile Arg Lys  Gln Met Leu 
    1070                 1075                 1080             


Gly Ile  Met Asp Arg His Lys  Leu Asp Val Val Ser  Cys Gly Lys 
    1085                 1090                 1095             


Ser Thr  Val Arg Val Gln Lys  Ala Ile Cys Ser Gly  Phe Phe Arg 
    1100                 1105                 1110             


Asn Ala  Ala Lys Lys Asp Pro  Gln Glu Gly Tyr Arg  Thr Leu Ile 
    1115                 1120                 1125             


Asp Gln  Gln Val Val Tyr Ile  His Pro Ser Ser Ala  Leu Phe Asn 
    1130                 1135                 1140             


Arg Gln  Pro Glu Cys Pro Lys  His Phe Leu Pro Val  Val Ala Val 
    1145                 1150                 1155             


Ala Val  Ser Leu Glu Gln Cys  Leu Ser Lys Phe Glu  Asp Leu Asn 
    1160                 1165                 1170             


Lys Glu  Leu Gly Leu Val Thr  Cys 
    1175                 1180     


<210>  3065
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHX9__Homo_sapiens__NP_001348

<400>  3065

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Gly Val Tyr  Pro Asn Val Cys Tyr  His Lys Glu 
        995                 1000                 1005             


Lys Arg  Lys Ile Leu Thr Thr  Glu Gly Arg Asn Ala  Leu Ile His 
    1010                 1015                 1020             


Lys Ser  Ser Val Asn Cys Pro  Phe Ser Ser Gln Asp  Met Lys Tyr 
    1025                 1030                 1035             


Pro Ser  Pro Phe Phe Val Phe  Gly Glu Lys Ile Arg  Thr Arg Ala 
    1040                 1045                 1050             


Ile Ser  Ala Lys Gly Met Thr  Leu Val Thr Pro Leu  Gln Leu Leu 
    1055                 1060                 1065             


Leu Phe  Ala Ser Lys Lys Val  Gln Ser Asp Gly Gln  Ile Val Leu 
    1070                 1075                 1080             


Val Asp  Asp Trp Ile Lys Leu  Gln Ile Ser His Glu  Ala Ala Ala 
    1085                 1090                 1095             


Cys Ile  Thr Gly Leu Arg Ala  Ala Met Glu Ala Leu  Val Val Glu 
    1100                 1105                 1110             


Val Thr  Lys Gln Pro Ala Ile  Ile Ser Gln Leu Asp  Pro Val Asn 
    1115                 1120                 1125             


Glu Arg  Met Leu Asn Met Ile  Arg Gln Ile Ser Arg  Pro Ser Ala 
    1130                 1135                 1140             


Ala Gly  Ile Asn Leu Met Ile  Gly Ser Thr Arg Tyr  Gly Asp Gly 
    1145                 1150                 1155             


Pro Arg  Pro Pro Lys Met Ala  Arg Tyr Asp Asn Gly  Ser Gly Tyr 
    1160                 1165                 1170             


Arg Arg  Gly Gly Ser Ser Tyr  Ser Gly Gly Gly Tyr  Gly Gly Gly 
    1175                 1180                 1185             


Tyr Ser  Ser Gly Gly Tyr Gly  Ser Gly Gly Tyr Gly  Gly Ser Ala 
    1190                 1195                 1200             


Asn Ser  Phe Arg Ala Gly Tyr  Gly Ala Gly Val Gly  Gly Gly Tyr 
    1205                 1210                 1215             


Arg Gly  Val Ser Arg Gly Gly  Phe Arg Gly Asn Ser  Gly Gly Asp 
    1220                 1225                 1230             


Tyr Arg  Gly Pro Ser Gly Gly  Tyr Arg Gly Ser Gly  Gly Phe Gln 
    1235                 1240                 1245             


Arg Gly  Gly Gly Arg Gly Ala  Tyr Gly Thr Gly Tyr  Phe Gly Gln 
    1250                 1255                 1260             


Gly Arg  Gly Gly Gly Gly Tyr  
    1265                 1270 


<210>  3066
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIABLO__Homo_sapiens__NP_001265233

<400>  3066

Met Lys Ser Asp Phe Tyr Phe Gln Lys Ser Glu Pro His Ser Leu Ser 
1               5                   10                  15      


Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr 
            20                  25                  30          


Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr 
        35                  40                  45              


Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr 
    50                  55                  60                  


Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp 
65                  70                  75                  80  


Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu 
                85                  90                  95      


Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu 
            100                 105                 110         


Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile 
        115                 120                 125             


Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val 
    130                 135                 140                 


His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly Glu Glu Arg Ala Glu 
                165                 170                 175     


Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp 
            180                 185     


<210>  3067
<211>  1263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIAPH1__Homo_sapiens__NP_001073280

<400>  3067

Met Glu Pro Pro Gly Gly Ser Leu Gly Pro Gly Arg Gly Thr Arg Asp 
1               5                   10                  15      


Lys Lys Lys Gly Arg Ser Pro Asp Glu Leu Pro Ser Ala Gly Gly Asp 
            20                  25                  30          


Gly Gly Lys Ser Lys Lys Phe Leu Glu Arg Phe Thr Ser Met Arg Ile 
        35                  40                  45              


Lys Lys Glu Lys Glu Lys Pro Asn Ser Ala His Arg Asn Ser Ser Ala 
    50                  55                  60                  


Ser Tyr Gly Asp Asp Pro Thr Ala Gln Ser Leu Gln Asp Val Ser Asp 
65                  70                  75                  80  


Glu Gln Val Leu Val Leu Phe Glu Gln Met Leu Leu Asp Met Asn Leu 
                85                  90                  95      


Asn Glu Glu Lys Gln Gln Pro Leu Arg Glu Lys Asp Ile Ile Ile Lys 
            100                 105                 110         


Arg Glu Met Val Ser Gln Tyr Leu Tyr Thr Ser Lys Ala Gly Met Ser 
        115                 120                 125             


Gln Lys Glu Ser Ser Lys Ser Ala Met Met Tyr Ile Gln Glu Leu Arg 
    130                 135                 140                 


Ser Gly Leu Arg Asp Met Pro Leu Leu Ser Cys Leu Glu Ser Leu Arg 
145                 150                 155                 160 


Val Ser Leu Asn Asn Asn Pro Val Ser Trp Val Gln Thr Phe Gly Ala 
                165                 170                 175     


Glu Gly Leu Ala Ser Leu Leu Asp Ile Leu Lys Arg Leu His Asp Glu 
            180                 185                 190         


Lys Glu Glu Thr Ala Gly Ser Tyr Asp Ser Arg Asn Lys His Glu Ile 
        195                 200                 205             


Ile Arg Cys Leu Lys Ala Phe Met Asn Asn Lys Phe Gly Ile Lys Thr 
    210                 215                 220                 


Met Leu Glu Thr Glu Glu Gly Ile Leu Leu Leu Val Arg Ala Met Asp 
225                 230                 235                 240 


Pro Ala Val Pro Asn Met Met Ile Asp Ala Ala Lys Leu Leu Ser Ala 
                245                 250                 255     


Leu Cys Ile Leu Pro Gln Pro Glu Asp Met Asn Glu Arg Val Leu Glu 
            260                 265                 270         


Ala Met Thr Glu Arg Ala Glu Met Asp Glu Val Glu Arg Phe Gln Pro 
        275                 280                 285             


Leu Leu Asp Gly Leu Lys Ser Gly Thr Thr Ile Ala Leu Lys Val Gly 
    290                 295                 300                 


Cys Leu Gln Leu Ile Asn Ala Leu Ile Thr Pro Ala Glu Glu Leu Asp 
305                 310                 315                 320 


Phe Arg Val His Ile Arg Ser Glu Leu Met Arg Leu Gly Leu His Gln 
                325                 330                 335     


Val Leu Gln Asp Leu Arg Glu Ile Glu Asn Glu Asp Met Arg Val Gln 
            340                 345                 350         


Leu Asn Val Phe Asp Glu Gln Gly Glu Glu Asp Ser Tyr Asp Leu Lys 
        355                 360                 365             


Gly Arg Leu Asp Asp Ile Arg Met Glu Met Asp Asp Phe Asn Glu Val 
    370                 375                 380                 


Phe Gln Ile Leu Leu Asn Thr Val Lys Asp Ser Lys Ala Glu Pro His 
385                 390                 395                 400 


Phe Leu Ser Ile Leu Gln His Leu Leu Leu Val Arg Asn Asp Tyr Glu 
                405                 410                 415     


Ala Arg Pro Gln Tyr Tyr Lys Leu Ile Glu Glu Cys Ile Ser Gln Ile 
            420                 425                 430         


Val Leu His Lys Asn Gly Ala Asp Pro Asp Phe Lys Cys Arg His Leu 
        435                 440                 445             


Gln Ile Glu Ile Glu Gly Leu Ile Asp Gln Met Ile Asp Lys Thr Lys 
    450                 455                 460                 


Val Glu Lys Ser Glu Ala Lys Ala Ala Glu Leu Glu Lys Lys Leu Asp 
465                 470                 475                 480 


Ser Glu Leu Thr Ala Arg His Glu Leu Gln Val Glu Met Lys Lys Met 
                485                 490                 495     


Glu Ser Asp Phe Glu Gln Lys Leu Gln Asp Leu Gln Gly Glu Lys Asp 
            500                 505                 510         


Ala Leu His Ser Glu Lys Gln Gln Ile Ala Thr Glu Lys Gln Asp Leu 
        515                 520                 525             


Glu Ala Glu Val Ser Gln Leu Thr Gly Glu Val Ala Lys Leu Thr Lys 
    530                 535                 540                 


Glu Leu Glu Asp Ala Lys Lys Glu Met Ala Ser Leu Ser Ala Ala Ala 
545                 550                 555                 560 


Ile Thr Val Pro Pro Ser Val Pro Ser Arg Ala Pro Val Pro Pro Ala 
                565                 570                 575     


Pro Pro Leu Pro Gly Asp Ser Gly Thr Ile Ile Pro Pro Pro Pro Ala 
            580                 585                 590         


Pro Gly Asp Ser Thr Thr Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Pro Pro Pro Leu Pro Gly Gly Val Cys Ile Ser Ser Pro Pro Ser Leu 
    610                 615                 620                 


Pro Gly Gly Thr Ala Ile Ser Pro Pro Pro Pro Leu Ser Gly Asp Ala 
625                 630                 635                 640 


Thr Ile Pro Pro Pro Pro Pro Leu Pro Glu Gly Val Gly Ile Pro Ser 
                645                 650                 655     


Pro Ser Ser Leu Pro Gly Gly Thr Ala Ile Pro Pro Pro Pro Pro Leu 
            660                 665                 670         


Pro Gly Ser Ala Arg Ile Pro Pro Pro Pro Pro Pro Leu Pro Gly Ser 
        675                 680                 685             


Ala Gly Ile Pro Pro Pro Pro Pro Pro Leu Pro Gly Glu Ala Gly Met 
    690                 695                 700                 


Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly Pro Gly Ile Pro Pro Pro 
705                 710                 715                 720 


Pro Pro Phe Pro Gly Gly Pro Gly Ile Pro Pro Pro Pro Pro Gly Met 
                725                 730                 735     


Gly Met Pro Pro Pro Pro Pro Phe Gly Phe Gly Val Pro Ala Ala Pro 
            740                 745                 750         


Val Leu Pro Phe Gly Leu Thr Pro Lys Lys Leu Tyr Lys Pro Glu Val 
        755                 760                 765             


Gln Leu Arg Arg Pro Asn Trp Ser Lys Leu Val Ala Glu Asp Leu Ser 
    770                 775                 780                 


Gln Asp Cys Phe Trp Thr Lys Val Lys Glu Asp Arg Phe Glu Asn Asn 
785                 790                 795                 800 


Glu Leu Phe Ala Lys Leu Thr Leu Thr Phe Ser Ala Gln Thr Lys Thr 
                805                 810                 815     


Ser Lys Ala Lys Lys Asp Gln Glu Gly Gly Glu Glu Lys Lys Ser Val 
            820                 825                 830         


Gln Lys Lys Lys Val Lys Glu Leu Lys Val Leu Asp Ser Lys Thr Ala 
        835                 840                 845             


Gln Asn Leu Ser Ile Phe Leu Gly Ser Phe Arg Met Pro Tyr Gln Glu 
    850                 855                 860                 


Ile Lys Asn Val Ile Leu Glu Val Asn Glu Ala Val Leu Thr Glu Ser 
865                 870                 875                 880 


Met Ile Gln Asn Leu Ile Lys Gln Met Pro Glu Pro Glu Gln Leu Lys 
                885                 890                 895     


Met Leu Ser Glu Leu Lys Asp Glu Tyr Asp Asp Leu Ala Glu Ser Glu 
            900                 905                 910         


Gln Phe Gly Val Val Met Gly Thr Val Pro Arg Leu Arg Pro Arg Leu 
        915                 920                 925             


Asn Ala Ile Leu Phe Lys Leu Gln Phe Ser Glu Gln Val Glu Asn Ile 
    930                 935                 940                 


Lys Pro Glu Ile Val Ser Val Thr Ala Ala Cys Glu Glu Leu Arg Lys 
945                 950                 955                 960 


Ser Glu Ser Phe Ser Asn Leu Leu Glu Ile Thr Leu Leu Val Gly Asn 
                965                 970                 975     


Tyr Met Asn Ala Gly Ser Arg Asn Ala Gly Ala Phe Gly Phe Asn Ile 
            980                 985                 990         


Ser Phe Leu Cys Lys Leu Arg Asp  Thr Lys Ser Thr Asp  Gln Lys Met 
        995                 1000                 1005             


Thr Leu  Leu His Phe Leu Ala  Glu Leu Cys Glu Asn  Asp Tyr Pro 
    1010                 1015                 1020             


Asp Val  Leu Lys Phe Pro Asp  Glu Leu Ala His Val  Glu Lys Ala 
    1025                 1030                 1035             


Ser Arg  Val Ser Ala Glu Asn  Leu Gln Lys Asn Leu  Asp Gln Met 
    1040                 1045                 1050             


Lys Lys  Gln Ile Ser Asp Val  Glu Arg Asp Val Gln  Asn Phe Pro 
    1055                 1060                 1065             


Ala Ala  Thr Asp Glu Lys Asp  Lys Phe Val Glu Lys  Met Thr Ser 
    1070                 1075                 1080             


Phe Val  Lys Asp Ala Gln Glu  Gln Tyr Asn Lys Leu  Arg Met Met 
    1085                 1090                 1095             


His Ser  Asn Met Glu Thr Leu  Tyr Lys Glu Leu Gly  Glu Tyr Phe 
    1100                 1105                 1110             


Leu Phe  Asp Pro Lys Lys Leu  Ser Val Glu Glu Phe  Phe Met Asp 
    1115                 1120                 1125             


Leu His  Asn Phe Arg Asn Met  Phe Leu Gln Ala Val  Lys Glu Asn 
    1130                 1135                 1140             


Gln Lys  Arg Arg Glu Thr Glu  Glu Lys Met Arg Arg  Ala Lys Leu 
    1145                 1150                 1155             


Ala Lys  Glu Lys Ala Glu Lys  Glu Arg Leu Glu Lys  Gln Gln Lys 
    1160                 1165                 1170             


Arg Glu  Gln Leu Ile Asp Met  Asn Ala Glu Gly Asp  Glu Thr Gly 
    1175                 1180                 1185             


Val Met  Asp Ser Leu Leu Glu  Ala Leu Gln Ser Gly  Ala Ala Phe 
    1190                 1195                 1200             


Arg Arg  Lys Arg Gly Pro Arg  Gln Ala Asn Arg Lys  Ala Gly Cys 
    1205                 1210                 1215             


Ala Val  Thr Ser Leu Leu Ala  Ser Glu Leu Thr Lys  Asp Asp Ala 
    1220                 1225                 1230             


Met Ala  Ala Val Pro Ala Lys  Val Ser Lys Asn Ser  Glu Thr Phe 
    1235                 1240                 1245             


Pro Thr  Ile Leu Glu Glu Ala  Lys Glu Leu Val Gly  Arg Ala Ser 
    1250                 1255                 1260             


<210>  3068
<211>  1101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIAPH2__Homo_sapiens__NP_006720

<400>  3068

Met Glu Gln Pro Gly Ala Ala Ala Ser Gly Ala Gly Gly Gly Ser Glu 
1               5                   10                  15      


Glu Pro Gly Gly Gly Arg Ser Asn Lys Arg Ser Ala Gly Asn Arg Ala 
            20                  25                  30          


Ala Asn Glu Glu Glu Thr Lys Asn Lys Pro Lys Leu Asn Ile Gln Ile 
        35                  40                  45              


Lys Thr Leu Ala Asp Asp Val Arg Asp Arg Ile Thr Ser Phe Arg Lys 
    50                  55                  60                  


Ser Thr Val Lys Lys Glu Lys Pro Leu Ile Gln His Pro Ile Asp Ser 
65                  70                  75                  80  


Gln Val Ala Met Ser Glu Phe Pro Ala Ala Gln Pro Leu Tyr Asp Glu 
                85                  90                  95      


Arg Ser Leu Asn Leu Ser Glu Lys Glu Val Leu Asp Leu Phe Glu Lys 
            100                 105                 110         


Met Met Glu Asp Met Asn Leu Asn Glu Glu Lys Lys Ala Pro Leu Arg 
        115                 120                 125             


Asn Lys Asp Phe Thr Thr Lys Arg Glu Met Val Val Gln Tyr Ile Ser 
    130                 135                 140                 


Ala Thr Ala Lys Ser Gly Gly Leu Lys Asn Ser Lys His Glu Cys Thr 
145                 150                 155                 160 


Leu Ser Ser Gln Glu Tyr Val His Glu Leu Arg Ser Gly Ile Ser Asp 
                165                 170                 175     


Glu Lys Leu Leu Asn Cys Leu Glu Ser Leu Arg Val Ser Leu Thr Ser 
            180                 185                 190         


Asn Pro Val Ser Trp Val Asn Asn Phe Gly His Glu Gly Leu Gly Leu 
        195                 200                 205             


Leu Leu Asp Glu Leu Glu Lys Leu Leu Asp Lys Lys Gln Gln Glu Asn 
    210                 215                 220                 


Ile Asp Lys Lys Asn Gln Tyr Lys Leu Ile Gln Cys Leu Lys Ala Phe 
225                 230                 235                 240 


Met Asn Asn Lys Phe Gly Leu Gln Arg Ile Leu Gly Asp Glu Arg Ser 
                245                 250                 255     


Leu Leu Leu Leu Ala Arg Ala Ile Asp Pro Lys Gln Pro Asn Met Met 
            260                 265                 270         


Thr Glu Ile Val Lys Ile Leu Ser Ala Ile Cys Ile Val Gly Glu Glu 
        275                 280                 285             


Asn Ile Leu Asp Lys Leu Leu Gly Ala Ile Thr Thr Ala Ala Glu Arg 
    290                 295                 300                 


Asn Asn Arg Glu Arg Phe Ser Pro Ile Val Glu Gly Leu Glu Asn Gln 
305                 310                 315                 320 


Glu Ala Leu Gln Leu Gln Val Ala Cys Met Gln Phe Ile Asn Ala Leu 
                325                 330                 335     


Val Thr Ser Pro Tyr Glu Leu Asp Phe Arg Ile His Leu Arg Asn Glu 
            340                 345                 350         


Phe Leu Arg Ser Gly Leu Lys Thr Met Leu Pro Asp Leu Lys Glu Lys 
        355                 360                 365             


Glu Asn Asp Glu Leu Asp Ile Gln Leu Lys Val Phe Asp Glu Asn Lys 
    370                 375                 380                 


Glu Asp Asp Leu Thr Glu Leu Ser His Arg Leu Asn Asp Ile Arg Ala 
385                 390                 395                 400 


Glu Met Asp Asp Met Asn Glu Val Tyr His Leu Leu Tyr Asn Met Leu 
                405                 410                 415     


Lys Asp Thr Ala Ala Glu Asn Tyr Phe Leu Ser Ile Leu Gln His Phe 
            420                 425                 430         


Leu Leu Ile Arg Asn Asp Tyr Tyr Ile Arg Pro Gln Tyr Tyr Lys Ile 
        435                 440                 445             


Ile Glu Glu Cys Val Ser Gln Ile Val Leu His Cys Ser Gly Met Asp 
    450                 455                 460                 


Pro Asp Phe Lys Tyr Arg Gln Arg Leu Asp Ile Asp Leu Thr His Leu 
465                 470                 475                 480 


Ile Asp Ser Cys Val Asn Lys Ala Lys Val Glu Glu Ser Glu Gln Lys 
                485                 490                 495     


Ala Ala Glu Phe Ser Lys Lys Phe Asp Glu Glu Phe Thr Ala Arg Gln 
            500                 505                 510         


Glu Ala Gln Ala Glu Leu Gln Lys Arg Asp Glu Lys Ile Lys Glu Leu 
        515                 520                 525             


Glu Ala Glu Ile Gln Gln Leu Arg Thr Gln Ala Gln Val Leu Ser Ser 
    530                 535                 540                 


Ser Ser Gly Ile Pro Gly Pro Pro Ala Ala Pro Pro Leu Pro Gly Val 
545                 550                 555                 560 


Gly Pro Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Gly Gly Ala Pro 
                565                 570                 575     


Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly Met Met Gly Ile Pro Pro 
            580                 585                 590         


Pro Pro Pro Pro Pro Leu Leu Phe Gly Gly Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Leu Gly Gly Val Pro Pro Pro Pro Gly Ile Ser Leu Asn Leu Pro Tyr 
    610                 615                 620                 


Gly Met Lys Gln Lys Lys Met Tyr Lys Pro Glu Val Ser Met Lys Arg 
625                 630                 635                 640 


Ile Asn Trp Ser Lys Ile Glu Pro Thr Glu Leu Ser Glu Asn Cys Phe 
                645                 650                 655     


Trp Leu Arg Val Lys Glu Asp Lys Phe Glu Asn Pro Asp Leu Phe Ala 
            660                 665                 670         


Lys Leu Ala Leu Asn Phe Ala Thr Gln Ile Lys Val Gln Lys Asn Ala 
        675                 680                 685             


Glu Ala Leu Glu Glu Lys Lys Thr Gly Pro Thr Lys Lys Lys Val Lys 
    690                 695                 700                 


Glu Leu Arg Ile Leu Asp Pro Lys Thr Ala Gln Asn Leu Ser Ile Phe 
705                 710                 715                 720 


Leu Gly Ser Tyr Arg Met Pro Tyr Glu Asp Ile Arg Asn Val Ile Leu 
                725                 730                 735     


Glu Val Asn Glu Asp Met Leu Ser Glu Ala Leu Ile Gln Asn Leu Val 
            740                 745                 750         


Lys His Leu Pro Glu Gln Lys Ile Leu Asn Glu Leu Ala Glu Leu Lys 
        755                 760                 765             


Asn Glu Tyr Asp Asp Leu Cys Glu Pro Glu Gln Phe Gly Val Val Met 
    770                 775                 780                 


Ser Ser Val Lys Met Leu Gln Pro Arg Leu Ser Ser Ile Leu Phe Lys 
785                 790                 795                 800 


Leu Thr Phe Glu Glu His Ile Asn Asn Ile Lys Pro Ser Ile Ile Ala 
                805                 810                 815     


Val Thr Leu Ala Cys Glu Glu Leu Lys Lys Ser Glu Ser Phe Asn Arg 
            820                 825                 830         


Leu Leu Glu Leu Val Leu Leu Val Gly Asn Tyr Met Asn Ser Gly Ser 
        835                 840                 845             


Arg Asn Ala Gln Ser Leu Gly Phe Lys Ile Asn Phe Leu Cys Lys Ile 
    850                 855                 860                 


Arg Asp Thr Lys Ser Ala Asp Gln Lys Thr Thr Leu Leu His Phe Ile 
865                 870                 875                 880 


Ala Asp Ile Cys Glu Glu Lys Tyr Arg Asp Ile Leu Lys Phe Pro Glu 
                885                 890                 895     


Glu Leu Glu His Val Glu Ser Ala Ser Lys Val Ser Ala Gln Ile Leu 
            900                 905                 910         


Lys Ser Asn Leu Ala Ser Met Glu Gln Gln Ile Val His Leu Glu Arg 
        915                 920                 925             


Asp Ile Lys Lys Phe Pro Gln Ala Glu Asn Gln His Asp Lys Phe Val 
    930                 935                 940                 


Glu Lys Met Thr Ser Phe Thr Lys Thr Ala Arg Glu Gln Tyr Glu Lys 
945                 950                 955                 960 


Leu Ser Thr Met His Asn Asn Met Met Lys Leu Tyr Glu Asn Leu Gly 
                965                 970                 975     


Glu Tyr Phe Ile Phe Asp Ser Lys Thr Val Ser Ile Glu Glu Phe Phe 
            980                 985                 990         


Gly Asp Leu Asn Asn Phe Arg Thr  Leu Phe Leu Glu Ala  Val Arg Glu 
        995                 1000                 1005             


Asn Asn  Lys Arg Arg Glu Met  Glu Glu Lys Thr Arg  Arg Ala Lys 
    1010                 1015                 1020             


Leu Ala  Lys Glu Lys Ala Glu  Gln Glu Lys Leu Glu  Arg Gln Lys 
    1025                 1030                 1035             


Lys Lys  Lys Gln Leu Ile Asp  Ile Asn Lys Glu Gly  Asp Glu Thr 
    1040                 1045                 1050             


Gly Val  Met Asp Asn Leu Leu  Glu Ala Leu Gln Ser  Gly Ala Ala 
    1055                 1060                 1065             


Phe Arg  Asp Arg Arg Lys Arg  Ile Pro Arg Asn Pro  Asp Asn Arg 
    1070                 1075                 1080             


Arg Val  Pro Leu Glu Arg Ser  Arg Ser Arg His Asn  Gly Ala Ile 
    1085                 1090                 1095             


Ser Ser  Lys 
    1100     


<210>  3069
<211>  1193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIAPH3__Homo_sapiens__NP_001035982

<400>  3069

Met Glu Arg His Gln Pro Arg Leu His His Pro Ala Gln Gly Ser Ala 
1               5                   10                  15      


Ala Gly Thr Pro Tyr Pro Ser Ser Ala Ser Leu Arg Gly Cys Arg Glu 
            20                  25                  30          


Ser Lys Met Pro Arg Arg Lys Gly Pro Gln His Pro Pro Pro Pro Ser 
        35                  40                  45              


Gly Pro Glu Glu Pro Gly Glu Lys Arg Pro Lys Phe His Leu Asn Ile 
    50                  55                  60                  


Arg Thr Leu Thr Asp Asp Met Leu Asp Lys Phe Ala Ser Ile Arg Ile 
65                  70                  75                  80  


Pro Gly Ser Lys Lys Glu Arg Pro Pro Leu Pro Asn Leu Lys Thr Ala 
                85                  90                  95      


Phe Ala Ser Ser Asp Cys Ser Ala Ala Pro Leu Glu Met Met Glu Asn 
            100                 105                 110         


Phe Pro Lys Pro Leu Ser Glu Asn Glu Leu Leu Glu Leu Phe Glu Lys 
        115                 120                 125             


Met Met Glu Asp Met Asn Leu Asn Glu Asp Lys Lys Ala Pro Leu Arg 
    130                 135                 140                 


Glu Lys Asp Phe Ser Ile Lys Lys Glu Met Val Met Gln Tyr Ile Asn 
145                 150                 155                 160 


Thr Ala Ser Lys Thr Gly Ser Leu Lys Arg Ser Arg Gln Ile Ser Pro 
                165                 170                 175     


Gln Glu Phe Ile His Glu Leu Lys Met Gly Ser Ala Asp Glu Arg Leu 
            180                 185                 190         


Val Thr Cys Leu Glu Ser Leu Arg Val Ser Leu Thr Ser Asn Pro Val 
        195                 200                 205             


Ser Trp Val Glu Ser Phe Gly His Glu Gly Leu Gly Leu Leu Leu Asp 
    210                 215                 220                 


Ile Leu Glu Lys Leu Ile Ser Gly Lys Ile Gln Glu Lys Val Val Lys 
225                 230                 235                 240 


Lys Asn Gln His Lys Val Ile Gln Cys Leu Lys Ala Leu Met Asn Thr 
                245                 250                 255     


Gln Tyr Gly Leu Glu Arg Ile Met Ser Glu Glu Arg Ser Leu Ser Leu 
            260                 265                 270         


Leu Ala Lys Ala Val Asp Pro Arg His Pro Asn Met Met Thr Asp Val 
        275                 280                 285             


Val Lys Leu Leu Ser Ala Val Cys Ile Val Gly Glu Glu Ser Ile Leu 
    290                 295                 300                 


Glu Glu Val Leu Glu Ala Leu Thr Ser Ala Gly Glu Glu Lys Lys Ile 
305                 310                 315                 320 


Asp Arg Phe Phe Cys Ile Val Glu Gly Leu Arg His Asn Ser Val Gln 
                325                 330                 335     


Leu Gln Val Ala Cys Met Gln Leu Ile Asn Ala Leu Val Thr Ser Pro 
            340                 345                 350         


Asp Asp Leu Asp Phe Arg Leu His Ile Arg Asn Glu Phe Met Arg Cys 
        355                 360                 365             


Gly Leu Lys Glu Ile Leu Pro Asn Leu Lys Cys Ile Lys Asn Asp Gly 
    370                 375                 380                 


Leu Asp Ile Gln Leu Lys Val Phe Asp Glu His Lys Glu Glu Asp Leu 
385                 390                 395                 400 


Phe Glu Leu Ser His Arg Leu Glu Asp Ile Arg Ala Glu Leu Asp Glu 
                405                 410                 415     


Ala Tyr Asp Val Tyr Asn Met Val Trp Ser Thr Val Lys Glu Thr Arg 
            420                 425                 430         


Ala Glu Gly Tyr Phe Ile Ser Ile Leu Gln His Leu Leu Leu Ile Arg 
        435                 440                 445             


Asn Asp Tyr Phe Ile Arg Gln Gln Tyr Phe Lys Leu Ile Asp Glu Cys 
    450                 455                 460                 


Val Ser Gln Ile Val Leu His Arg Asp Gly Met Asp Pro Asp Phe Thr 
465                 470                 475                 480 


Tyr Arg Lys Arg Leu Asp Leu Asp Leu Thr Gln Phe Val Asp Ile Cys 
                485                 490                 495     


Ile Asp Gln Ala Lys Leu Glu Glu Phe Glu Glu Lys Ala Ser Glu Leu 
            500                 505                 510         


Tyr Lys Lys Phe Glu Lys Glu Phe Thr Asp His Gln Glu Thr Gln Ala 
        515                 520                 525             


Glu Leu Gln Lys Lys Glu Ala Lys Ile Asn Glu Leu Gln Ala Glu Leu 
    530                 535                 540                 


Gln Ala Phe Lys Ser Gln Phe Gly Ala Leu Pro Ala Asp Cys Asn Ile 
545                 550                 555                 560 


Pro Leu Pro Pro Ser Lys Glu Gly Gly Thr Gly His Ser Ala Leu Pro 
                565                 570                 575     


Pro Pro Pro Pro Leu Pro Ser Gly Gly Gly Val Pro Pro Pro Pro Pro 
            580                 585                 590         


Pro Pro Pro Pro Pro Pro Leu Pro Gly Met Arg Met Pro Phe Ser Gly 
        595                 600                 605             


Pro Val Pro Pro Pro Pro Pro Leu Gly Phe Leu Gly Gly Gln Asn Ser 
    610                 615                 620                 


Pro Pro Leu Pro Ile Leu Pro Phe Gly Leu Lys Pro Lys Lys Glu Phe 
625                 630                 635                 640 


Lys Pro Glu Ile Ser Met Arg Arg Leu Asn Trp Leu Lys Ile Arg Pro 
                645                 650                 655     


His Glu Met Thr Glu Asn Cys Phe Trp Ile Lys Val Asn Glu Asn Lys 
            660                 665                 670         


Tyr Glu Asn Val Asp Leu Leu Cys Lys Leu Glu Asn Thr Phe Cys Cys 
        675                 680                 685             


Gln Gln Lys Glu Arg Arg Glu Glu Glu Asp Ile Glu Glu Lys Lys Ser 
    690                 695                 700                 


Ile Lys Lys Lys Ile Lys Glu Leu Lys Phe Leu Asp Ser Lys Ile Ala 
705                 710                 715                 720 


Gln Asn Leu Ser Ile Phe Leu Ser Ser Phe Arg Val Pro Tyr Glu Glu 
                725                 730                 735     


Ile Arg Met Met Ile Leu Glu Val Asp Glu Thr Arg Leu Ala Glu Ser 
            740                 745                 750         


Met Ile Gln Asn Leu Ile Lys His Leu Pro Asp Gln Glu Gln Leu Asn 
        755                 760                 765             


Ser Leu Ser Gln Phe Lys Ser Glu Tyr Ser Asn Leu Cys Glu Pro Glu 
    770                 775                 780                 


Gln Phe Val Val Val Met Ser Asn Val Lys Arg Leu Arg Pro Arg Leu 
785                 790                 795                 800 


Ser Ala Ile Leu Phe Lys Leu Gln Phe Glu Glu Gln Val Asn Asn Ile 
                805                 810                 815     


Lys Pro Asp Ile Met Ala Val Ser Thr Ala Cys Glu Glu Ile Lys Lys 
            820                 825                 830         


Ser Lys Ser Phe Ser Lys Leu Leu Glu Leu Val Leu Leu Met Gly Asn 
        835                 840                 845             


Tyr Met Asn Ala Gly Ser Arg Asn Ala Gln Thr Phe Gly Phe Asn Leu 
    850                 855                 860                 


Ser Ser Leu Cys Lys Leu Lys Asp Thr Lys Ser Ala Asp Gln Lys Thr 
865                 870                 875                 880 


Thr Leu Leu His Phe Leu Val Glu Ile Cys Glu Glu Lys Tyr Pro Asp 
                885                 890                 895     


Ile Leu Asn Phe Val Asp Asp Leu Glu Pro Leu Asp Lys Ala Ser Lys 
            900                 905                 910         


Val Ser Val Glu Thr Leu Glu Lys Asn Leu Arg Gln Met Gly Arg Gln 
        915                 920                 925             


Leu Gln Gln Leu Glu Lys Glu Leu Glu Thr Phe Pro Pro Pro Glu Asp 
    930                 935                 940                 


Leu His Asp Lys Phe Val Thr Lys Met Ser Arg Phe Val Ile Ser Ala 
945                 950                 955                 960 


Lys Glu Gln Tyr Glu Thr Leu Ser Lys Leu His Glu Asn Met Glu Lys 
                965                 970                 975     


Leu Tyr Gln Ser Ile Ile Gly Tyr Tyr Ala Ile Asp Val Lys Lys Val 
            980                 985                 990         


Ser Val Glu Asp Phe Leu Thr Asp  Leu Asn Asn Phe Arg  Thr Thr Phe 
        995                 1000                 1005             


Met Gln  Ala Ile Lys Glu Asn  Ile Lys Lys Arg Glu  Ala Glu Glu 
    1010                 1015                 1020             


Lys Glu  Lys Arg Val Arg Ile  Ala Lys Glu Leu Ala  Glu Arg Glu 
    1025                 1030                 1035             


Arg Leu  Glu Arg Gln Gln Lys  Lys Lys Arg Leu Leu  Glu Met Lys 
    1040                 1045                 1050             


Thr Glu  Gly Asp Glu Thr Gly  Val Met Asp Asn Leu  Leu Glu Ala 
    1055                 1060                 1065             


Leu Gln  Ser Gly Ala Ala Phe  Arg Asp Arg Arg Lys  Arg Thr Pro 
    1070                 1075                 1080             


Met Pro  Lys Asp Val Arg Gln  Ser Leu Ser Pro Met  Ser Gln Arg 
    1085                 1090                 1095             


Pro Val  Leu Lys Val Cys Asn  His Glu Asn Gln Lys  Val Gln Leu 
    1100                 1105                 1110             


Thr Glu  Gly Ser Arg Ser His  Tyr Asn Ile Asn Cys  Asn Ser Thr 
    1115                 1120                 1125             


Arg Thr  Pro Val Ala Lys Glu  Leu Asn Tyr Asn Leu  Asp Thr His 
    1130                 1135                 1140             


Thr Ser  Thr Gly Arg Ile Lys  Ala Ala Glu Lys Lys  Glu Ala Cys 
    1145                 1150                 1155             


Asn Val  Glu Ser Asn Arg Lys  Lys Glu Thr Glu Leu  Leu Gly Ser 
    1160                 1165                 1170             


Phe Ser  Lys Asn Glu Ser Val  Pro Glu Val Glu Ala  Leu Leu Ala 
    1175                 1180                 1185             


Arg Leu  Arg Ala Leu 
    1190             


<210>  3070
<211>  1829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DICER1__Homo_sapiens__NP_001182502

<400>  3070

Met Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu 
1               5                   10                  15      


Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp 
            20                  25                  30          


Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln 
        35                  40                  45              


Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu 
    50                  55                  60                  


Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu 
65                  70                  75                  80  


Leu Ser Tyr Gln Ile Arg Gly Asp Phe Ser Arg Asn Gly Lys Arg Thr 
                85                  90                  95      


Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala 
            100                 105                 110         


Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu 
        115                 120                 125             


Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Asn Gln Glu Phe Thr Lys 
    130                 135                 140                 


His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys 
145                 150                 155                 160 


Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu 
                165                 170                 175     


Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu 
            180                 185                 190         


Cys Glu Asn Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser 
        195                 200                 205             


Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln 
    210                 215                 220                 


Lys Leu Glu Lys Ile Leu Lys Ser Asn Ala Glu Thr Ala Thr Asp Leu 
225                 230                 235                 240 


Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp 
                245                 250                 255     


Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met 
            260                 265                 270         


Glu Leu Glu Glu Ala Leu Asn Phe Ile Asn Asp Cys Asn Ile Ser Val 
        275                 280                 285             


His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser 
    290                 295                 300                 


Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys 
305                 310                 315                 320 


Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu 
                325                 330                 335     


Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Phe Leu 
            340                 345                 350         


Arg Lys Ile His Ala Leu Cys Glu Glu His Phe Ser Pro Ala Ser Leu 
        355                 360                 365             


Asp Leu Lys Phe Val Thr Pro Lys Val Ile Lys Leu Leu Glu Ile Leu 
    370                 375                 380                 


Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp 
385                 390                 395                 400 


Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu 
                405                 410                 415     


Asp Asp Asp Glu Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr 
            420                 425                 430         


Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val 
        435                 440                 445             


Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala 
    450                 455                 460                 


Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr 
465                 470                 475                 480 


Gly His Gly Ile Gly Lys Asn Gln Pro Arg Asn Lys Gln Met Glu Ala 
                485                 490                 495     


Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu 
            500                 505                 510         


Thr Asn Leu Leu Ile Ala Thr Ser Ile Val Glu Glu Gly Val Asp Ile 
        515                 520                 525             


Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg 
    530                 535                 540                 


Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr 
545                 550                 555                 560 


Ile Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu 
                565                 570                 575     


Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys 
            580                 585                 590         


Ser Val Asp Thr Gly Glu Thr Asp Ile Asp Pro Val Met Asp Asp Asp 
        595                 600                 605             


Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg 
    610                 615                 620                 


Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg 
625                 630                 635                 640 


Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg 
                645                 650                 655     


Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn 
            660                 665                 670         


Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Ser Cys Val Arg 
        675                 680                 685             


Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys 
    690                 695                 700                 


Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly Lys Glu Thr Val 
705                 710                 715                 720 


Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val 
                725                 730                 735     


Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala 
            740                 745                 750         


Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Arg Pro Asp Gln Pro Cys 
        755                 760                 765             


Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu 
    770                 775                 780                 


Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg 
785                 790                 795                 800 


Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe 
                805                 810                 815     


Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys 
            820                 825                 830         


Lys Ser Gly Phe Met Leu Ser Leu Gln Met Leu Glu Leu Ile Thr Arg 
        835                 840                 845             


Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala 
    850                 855                 860                 


Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr Cys Val Leu Pro 
865                 870                 875                 880 


Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile Asp Phe Lys Phe 
                885                 890                 895     


Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr 
            900                 905                 910         


Lys Tyr Thr Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln 
        915                 920                 925             


Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg 
    930                 935                 940                 


Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe 
945                 950                 955                 960 


Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr 
                965                 970                 975     


Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His 
            980                 985                 990         


Thr Ser Ser Arg Leu Asn Leu Leu  Thr Pro Arg His Leu  Asn Gln Lys 
        995                 1000                 1005             


Gly Lys  Ala Leu Pro Leu Ser  Ser Ala Glu Lys Arg  Lys Ala Lys 
    1010                 1015                 1020             


Trp Glu  Ser Leu Gln Asn Lys  Gln Ile Leu Val Pro  Glu Leu Cys 
    1025                 1030                 1035             


Ala Ile  His Pro Ile Pro Ala  Ser Leu Trp Arg Lys  Ala Val Cys 
    1040                 1045                 1050             


Leu Pro  Ser Ile Leu Tyr Arg  Leu His Cys Leu Leu  Thr Ala Glu 
    1055                 1060                 1065             


Glu Leu  Arg Ala Gln Thr Ala  Ser Asp Ala Gly Val  Gly Val Arg 
    1070                 1075                 1080             


Ser Leu  Pro Ala Asp Phe Arg  Tyr Pro Asn Leu Asp  Phe Gly Trp 
    1085                 1090                 1095             


Lys Lys  Ser Ile Asp Ser Lys  Ser Phe Ile Ser Ile  Ser Asn Ser 
    1100                 1105                 1110             


Ser Ser  Ala Glu Asn Asp Asn  Tyr Cys Lys His Ser  Thr Ile Val 
    1115                 1120                 1125             


Pro Glu  Asn Ala Ala His Gln  Gly Ala Asn Arg Thr  Ser Ser Leu 
    1130                 1135                 1140             


Glu Asn  His Asp Gln Met Ser  Val Asn Cys Arg Thr  Leu Leu Ser 
    1145                 1150                 1155             


Glu Ser  Pro Gly Lys Leu His  Val Glu Val Ser Ala  Asp Leu Thr 
    1160                 1165                 1170             


Ala Ile  Asn Gly Leu Ser Tyr  Asn Gln Asn Leu Ala  Asn Gly Ser 
    1175                 1180                 1185             


Tyr Asp  Leu Ala Asn Arg Asp  Phe Cys Gln Gly Asn  Gln Leu Asn 
    1190                 1195                 1200             


Tyr Tyr  Lys Gln Glu Ile Pro  Val Gln Pro Thr Thr  Ser Tyr Ser 
    1205                 1210                 1215             


Ile Gln  Asn Leu Tyr Ser Tyr  Glu Asn Gln Pro Gln  Pro Ser Asp 
    1220                 1225                 1230             


Glu Cys  Thr Leu Leu Ser Asn  Lys Tyr Leu Asp Gly  Asn Ala Asn 
    1235                 1240                 1245             


Lys Ser  Thr Ser Asp Gly Ser  Pro Val Met Ala Val  Met Pro Gly 
    1250                 1255                 1260             


Thr Thr  Asp Thr Ile Gln Val  Leu Lys Gly Arg Met  Asp Ser Glu 
    1265                 1270                 1275             


Gln Ser  Pro Ser Ile Gly Tyr  Ser Ser Arg Thr Leu  Gly Pro Asn 
    1280                 1285                 1290             


Pro Gly  Leu Ile Leu Gln Ala  Leu Thr Leu Ser Asn  Ala Ser Asp 
    1295                 1300                 1305             


Gly Phe  Asn Leu Glu Arg Leu  Glu Met Leu Gly Asp  Ser Phe Leu 
    1310                 1315                 1320             


Lys His  Ala Ile Thr Thr Tyr  Leu Phe Cys Thr Tyr  Pro Asp Ala 
    1325                 1330                 1335             


His Glu  Gly Arg Leu Ser Tyr  Met Arg Ser Lys Lys  Val Ser Asn 
    1340                 1345                 1350             


Cys Asn  Leu Tyr Arg Leu Gly  Lys Lys Lys Gly Leu  Pro Ser Arg 
    1355                 1360                 1365             


Met Val  Val Ser Ile Phe Asp  Pro Pro Val Asn Trp  Leu Pro Pro 
    1370                 1375                 1380             


Gly Tyr  Val Val Asn Gln Asp  Lys Ser Asn Thr Asp  Lys Trp Glu 
    1385                 1390                 1395             


Lys Asp  Glu Met Thr Lys Asp  Cys Met Leu Ala Asn  Gly Lys Leu 
    1400                 1405                 1410             


Asp Glu  Asp Tyr Glu Glu Glu  Asp Glu Glu Glu Glu  Ser Leu Met 
    1415                 1420                 1425             


Trp Arg  Ala Pro Lys Glu Glu  Ala Asp Tyr Glu Asp  Asp Phe Leu 
    1430                 1435                 1440             


Glu Tyr  Asp Gln Glu His Ile  Arg Phe Ile Asp Asn  Met Leu Met 
    1445                 1450                 1455             


Gly Ser  Gly Ala Phe Val Lys  Lys Ile Ser Leu Ser  Pro Phe Ser 
    1460                 1465                 1470             


Thr Thr  Asp Ser Ala Tyr Glu  Trp Lys Met Pro Lys  Lys Ser Ser 
    1475                 1480                 1485             


Leu Gly  Ser Met Pro Phe Ser  Ser Asp Phe Glu Asp  Phe Asp Tyr 
    1490                 1495                 1500             


Ser Ser  Trp Asp Ala Met Cys  Tyr Leu Asp Pro Ser  Lys Ala Val 
    1505                 1510                 1515             


Glu Glu  Asp Asp Phe Val Val  Gly Phe Trp Asn Pro  Ser Glu Glu 
    1520                 1525                 1530             


Asn Cys  Gly Val Asp Thr Gly  Lys Gln Ser Ile Ser  Tyr Asp Leu 
    1535                 1540                 1545             


His Thr  Glu Gln Cys Ile Ala  Asp Lys Ser Ile Ala  Asp Cys Val 
    1550                 1555                 1560             


Glu Ala  Leu Leu Gly Cys Tyr  Leu Thr Ser Cys Gly  Glu Arg Ala 
    1565                 1570                 1575             


Ala Gln  Leu Phe Leu Cys Ser  Leu Gly Leu Lys Val  Leu Pro Val 
    1580                 1585                 1590             


Ile Lys  Arg Thr Asp Arg Glu  Lys Ala Leu Cys Pro  Thr Arg Glu 
    1595                 1600                 1605             


Asn Phe  Asn Ser Gln Gln Lys  Asn Leu Ser Val Ser  Cys Ala Ala 
    1610                 1615                 1620             


Ala Ser  Val Ala Ser Ser Arg  Ser Ser Val Leu Lys  Asp Ser Glu 
    1625                 1630                 1635             


Tyr Gly  Cys Leu Lys Ile Pro  Pro Arg Cys Met Phe  Asp His Pro 
    1640                 1645                 1650             


Asp Ala  Asp Lys Thr Leu Asn  His Leu Ile Ser Gly  Phe Glu Asn 
    1655                 1660                 1665             


Phe Glu  Lys Lys Ile Asn Tyr  Arg Phe Lys Asn Lys  Ala Tyr Leu 
    1670                 1675                 1680             


Leu Gln  Ala Phe Thr His Ala  Ser Tyr His Tyr Asn  Thr Ile Thr 
    1685                 1690                 1695             


Asp Cys  Tyr Gln Arg Leu Glu  Phe Leu Gly Asp Ala  Ile Leu Asp 
    1700                 1705                 1710             


Tyr Leu  Ile Thr Lys His Leu  Tyr Glu Asp Pro Arg  Gln His Ser 
    1715                 1720                 1725             


Pro Gly  Val Leu Thr Asp Leu  Arg Ser Ala Leu Val  Asn Asn Thr 
    1730                 1735                 1740             


Ile Phe  Ala Ser Leu Ala Val  Lys Tyr Asp Tyr His  Lys Tyr Phe 
    1745                 1750                 1755             


Lys Ala  Val Ser Pro Glu Leu  Phe His Val Ile Asp  Asp Phe Val 
    1760                 1765                 1770             


Gln Phe  Gln Leu Glu Lys Asn  Glu Met Gln Gly Met  Asp Ser Glu 
    1775                 1780                 1785             


Lys Ser  Phe Leu Gln Met Tyr  Pro Val Pro Leu Cys  Glu Asn Cys 
    1790                 1795                 1800             


Leu Lys  Trp Asn Gln Lys Leu  Pro Asn Leu Ala Arg  Leu Arg Glu 
    1805                 1810                 1815             


Leu Thr  Thr Gly Arg Ser Glu  Ser Leu Trp Lys 
    1820                 1825                 


<210>  3071
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIDO1__Homo_sapiens__NP_071388

<400>  3071

Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Cys Met Tyr His Leu Gly Val Gly Leu Leu Asp Pro Ser Arg Ser 
    530                 535                 540                 


Phe Trp Ile Ala Ile Pro Trp Ala Cys Pro Gly Leu Gly Val Ala Ala 
545                 550                 555                 560 


Leu Cys 
        


<210>  3072
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIEXF__Homo_sapiens__NP_055203

<400>  3072

Met Gly Lys Arg Gly Ser Arg Ser Gln Ser Gln Leu Leu Asn Thr Leu 
1               5                   10                  15      


Thr Lys Lys Gln Lys Lys His Leu Arg Asp Phe Gly Glu Glu His Pro 
            20                  25                  30          


Phe Tyr Asp Arg Val Ser Arg Lys Glu Ala Lys Pro Gln Ile Cys Gln 
        35                  40                  45              


Leu Ser Glu Ser Ser Asp Ser Ser Asp Ser Glu Ser Asp Ser Glu Ser 
    50                  55                  60                  


Glu Pro Gln Gln Val Ser Gly Tyr His Arg Leu Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Asn Val Ser Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Asp Ser Ile Val Asp Asp Ala Glu Met Asn Asp Glu Asp Gly Gly Ser 
            100                 105                 110         


Asp Val Ser Val Glu Glu Glu Met Ala Ala Glu Ser Thr Glu Ser Pro 
        115                 120                 125             


Glu Asn Val Ala Leu Ser Ala Asp Pro Glu Gly Lys Glu Asp Gly Glu 
    130                 135                 140                 


Glu Pro Pro Gly Thr Ser Gln Thr Ser Pro Glu Glu Phe Thr Asp Ala 
145                 150                 155                 160 


Lys His Glu Ser Leu Phe Ser Leu Glu Thr Asn Phe Leu Glu Glu Glu 
                165                 170                 175     


Ser Gly Asp Asn Ser Ser Leu Lys Ala Ser Gln Asp Pro Phe Leu Gln 
            180                 185                 190         


His Val Asn Lys Glu Leu Lys Glu Lys Ala Ile Gln Ala Val Ala Thr 
        195                 200                 205             


Asn Pro Lys Thr Thr His Glu Leu Lys Trp Pro Ile Leu Gly Gln Leu 
    210                 215                 220                 


Phe Phe Ser Ser Lys Phe Gln Lys Leu Glu Thr Phe Lys Pro Pro Lys 
225                 230                 235                 240 


Asp Ile Asp Leu Lys Ser Leu His Leu Gln Lys Pro Leu Glu Ser Thr 
                245                 250                 255     


Trp Thr Lys Thr Asn Ser Gln Phe Leu Ser Gly Pro Gln Lys Ser Ser 
            260                 265                 270         


Ser Pro Phe Thr Pro Leu Gln Lys Glu Leu Phe Leu Ile Met Asn Ser 
        275                 280                 285             


Tyr Arg Asp Leu Phe Tyr Pro Glu Arg Thr Ala Leu Lys Asn Gly Glu 
    290                 295                 300                 


Glu Ile Arg His Val Tyr Cys Leu His Val Ile Asn His Ile Leu Lys 
305                 310                 315                 320 


Ala Asn Ala Gln Val Leu Gly Asn Asn Ser Arg Arg Arg Ser Gln Lys 
                325                 330                 335     


Phe Gly Val Gly Asp Asp Asp Asp Phe Arg Asp Gln Gly Leu Thr Arg 
            340                 345                 350         


Pro Lys Val Leu Ile Val Val Pro Phe Arg Glu Ala Ala Leu Arg Val 
        355                 360                 365             


Val Gln Leu Phe Ile Ser Leu Leu Glu Gly Asp Ser Lys Lys Lys Ile 
    370                 375                 380                 


Ile Val Ser Asn Lys Lys Arg Phe Gln Gly Glu Tyr Gly Ser Asp Pro 
385                 390                 395                 400 


Glu Glu Arg Pro Pro Asn Leu Lys Arg Pro Glu Asp Tyr Glu Ala Val 
                405                 410                 415     


Phe Val Gly Asn Ile Asp Asp His Phe Arg Ile Gly Val Ala Ile Leu 
            420                 425                 430         


Gln Arg Ser Ile Arg Leu Tyr Ala Pro Phe Tyr Ser Ser Asp Ile Leu 
        435                 440                 445             


Ile Ala Ser Pro Leu Gly Leu Arg Thr Ile Ile Gly Gly Glu Gly Glu 
    450                 455                 460                 


Lys Lys Arg Asp Phe Asp Phe Leu Ser Ser Ile Glu Leu Leu Ile Ile 
465                 470                 475                 480 


Asp Gln Ala Asp Ile Tyr Leu Met Gln Asn Trp Glu His Val Leu His 
                485                 490                 495     


Leu Met Asn His Met Asn Leu Leu Pro Leu Asp Ser His Gly Val Asp 
            500                 505                 510         


Phe Ser Arg Val Arg Met Trp Ser Leu Asn Asn Trp Ser Lys Tyr Tyr 
        515                 520                 525             


Arg Gln Thr Leu Leu Phe Gly Ala Leu Gln Asp Ala Gln Ile Asn Ser 
    530                 535                 540                 


Val Phe Asn Lys Tyr Cys Val Asn Met Gln Gly Gln Val Ala Val Arg 
545                 550                 555                 560 


Asn Val Pro Met Thr Gly Ser Ile Ser His Val Leu Val Gln Leu Pro 
                565                 570                 575     


His Val Phe Gln Arg Met Glu Ala Glu Asn Leu Ala Ser Val Ile Asp 
            580                 585                 590         


Ala Arg Phe Asn Phe Phe Val Asn Lys Ile Leu Pro Gln Tyr Arg Asp 
        595                 600                 605             


Ala Val Met Ser His Thr Leu Ile Tyr Ile Pro Ser Tyr Phe Asp Phe 
    610                 615                 620                 


Val Arg Leu Arg Asn Tyr Phe Lys Lys Glu Glu Leu Asn Phe Thr His 
625                 630                 635                 640 


Ile Cys Glu Tyr Thr Gln Lys Ser Gly Val Ser Arg Ala Arg His Phe 
                645                 650                 655     


Phe Leu Gln Gly Glu Lys Gln Phe Leu Leu Phe Thr Glu Arg Phe His 
            660                 665                 670         


Phe Tyr Lys Arg Tyr Thr Ile Lys Gly Ile Arg Asn Leu Ile Phe Tyr 
        675                 680                 685             


Glu Leu Pro Thr Tyr Pro His Phe Tyr Ser Glu Ile Cys Asn Met Leu 
    690                 695                 700                 


Arg Ala Thr Asn Arg Gly Glu Glu Ala Thr Trp Thr Cys Thr Val Leu 
705                 710                 715                 720 


Tyr Ser Lys Tyr Asp Ala Gln Arg Leu Ala Ala Val Val Gly Val Glu 
                725                 730                 735     


Arg Ala Ala Gln Met Leu Gln Ser Asn Lys Asn Val His Leu Phe Ile 
            740                 745                 750         


Thr Gly Glu Lys 
        755     


<210>  3073
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIP2A__Homo_sapiens__NP_001139587

<400>  3073

Met Ala Asp Arg Gly Cys Pro Leu Glu Ala Ala Pro Leu Pro Ala Glu 
1               5                   10                  15      


Val Arg Glu Ser Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp 
            20                  25                  30          


Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ala Lys Leu Leu Ala Arg 
        35                  40                  45              


Tyr Ile Pro Leu Ile Gln Gly Ile Asp Pro Ser Leu Gln Ala Glu Asn 
    50                  55                  60                  


Arg Ile Pro Gly Pro Ser Gln Thr Thr Ala Ala Ala Pro Lys Gln Gln 
65                  70                  75                  80  


Lys Ser Arg Pro Thr Ala Ser Arg Asp Glu Arg Phe Arg Ser Asp Val 
                85                  90                  95      


His Thr Glu Ala Val Gln Ala Ala Leu Ala Lys Tyr Lys Glu Arg Lys 
            100                 105                 110         


Met Pro Met Pro Ser Lys Arg Arg Ser Val Leu Val His Ser Ser Val 
        115                 120                 125             


Glu Thr Tyr Thr Pro Pro Asp Thr Ser Ser Ala Ser Glu Asp Glu Gly 
    130                 135                 140                 


Ser Leu Arg Arg Pro Gly Arg Leu Thr Ser Thr Pro Leu Gln Ser His 
145                 150                 155                 160 


Ser Ser Val Glu Pro Trp Leu Asp Arg Val Ile Gln Gly Ser Ser Thr 
                165                 170                 175     


Ser Ser Ser Ala Ser Ser Thr Ser Ser His Pro Gly Gly Arg Pro Thr 
            180                 185                 190         


Thr Ala Pro Ser Ala Ala Ala Thr Pro Gly Ala Ala Ala Thr Thr Ala 
        195                 200                 205             


Leu Ala Gly Leu Glu Ala His Thr His Ile Gly Val Pro Val Asn Ser 
    210                 215                 220                 


Arg Val Ser Ser Lys Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro 
225                 230                 235                 240 


Lys Arg Pro Pro Leu Lys Glu Phe Phe Val Asp Asp Phe Glu Glu Leu 
                245                 250                 255     


Leu Glu Val Gln Gln Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ser 
            260                 265                 270         


Glu Thr Ser Val Leu Arg Gly Glu Pro Leu Thr Ala Gly Val Pro Arg 
        275                 280                 285             


Pro Pro Ser Leu Leu Ala Thr Leu Gln Arg Trp Gly Thr Thr Gln Pro 
    290                 295                 300                 


Lys Ser Pro Cys Leu Thr Ala Leu Asp Thr Thr Gly Lys Ala Val Tyr 
305                 310                 315                 320 


Thr Leu Thr Tyr Gly Lys Leu Trp Ser Arg Ser Leu Lys Leu Ala Tyr 
                325                 330                 335     


Thr Leu Leu Asn Lys Leu Thr Ser Lys Asn Glu Pro Leu Leu Lys Pro 
            340                 345                 350         


Gly Asp Arg Val Ala Leu Val Phe Pro Asn Ser Asp Pro Val Met Phe 
        355                 360                 365             


Met Val Ala Phe Tyr Gly Cys Leu Leu Ala Glu Leu Val Pro Val Pro 
    370                 375                 380                 


Ile Glu Val Pro Leu Thr Arg Lys Asp Ala Gly Ser Gln Gln Val Gly 
385                 390                 395                 400 


Phe Leu Leu Gly Ser Cys Gly Val Phe Leu Ala Leu Thr Thr Asp Ala 
                405                 410                 415     


Cys Gln Lys Gly Leu Pro Lys Ala Gln Thr Gly Glu Val Ala Ala Phe 
            420                 425                 430         


Lys Gly Trp Pro Pro Leu Ser Trp Leu Val Ile Asp Gly Lys His Leu 
        435                 440                 445             


Ala Lys Pro Pro Lys Asp Trp His Pro Leu Ala Gln Asp Thr Gly Thr 
    450                 455                 460                 


Gly Thr Ala Tyr Ile Glu Tyr Lys Thr Ser Lys Glu Gly Ser Thr Val 
465                 470                 475                 480 


Gly Val Thr Val Ser His Ala Ser Leu Leu Ala Gln Cys Arg Ala Leu 
                485                 490                 495     


Thr Gln Ala Cys Gly Tyr Ser Glu Ala Glu Thr Leu Thr Asn Val Leu 
            500                 505                 510         


Asp Phe Lys Arg Asp Ala Gly Leu Trp His Gly Val Leu Thr Ser Val 
        515                 520                 525             


Met Asn Arg Met His Val Val Ser Val Pro Tyr Ala Leu Met Lys Ala 
    530                 535                 540                 


Asn Pro Leu Ser Trp Ile Gln Lys Val Cys Phe Tyr Lys Ala Arg Ala 
545                 550                 555                 560 


Ala Leu Val Lys Ser Arg Asp Met His Trp Ser Leu Leu Ala Gln Arg 
                565                 570                 575     


Gly Gln Arg Asp Val Ser Leu Ser Ser Leu Arg Met Leu Ile Val Ala 
            580                 585                 590         


Asp Gly Ala Asn Pro Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn 
        595                 600                 605             


Val Phe Gln Ser Arg Gly Leu Arg Pro Glu Val Ile Cys Pro Cys Ala 
    610                 615                 620                 


Ser Ser Pro Glu Ala Leu Thr Val Ala Ile Arg Arg Pro Pro Asp Leu 
625                 630                 635                 640 


Gly Gly Pro Pro Pro Arg Lys Ala Val Leu Ser Met Asn Gly Leu Ser 
                645                 650                 655     


Tyr Gly Val Ile Arg Val Asp Thr Glu Glu Lys Leu Ser Val Leu Thr 
            660                 665                 670         


Val Gln Asp Val Gly Gln Val Met Pro Gly Ala Asn Val Cys Val Val 
        675                 680                 685             


Lys Leu Glu Gly Thr Pro Tyr Leu Cys Lys Thr Asp Glu Val Gly Glu 
    690                 695                 700                 


Ile Cys Val Ser Ser Ser Ala Thr Gly Thr Ala Tyr Tyr Gly Leu Leu 
705                 710                 715                 720 


Gly Ile Thr Lys Asn Val Phe Glu Ala Val Pro Val Thr Thr Gly Gly 
                725                 730                 735     


Ala Pro Ile Phe Asp Arg Pro Phe Thr Arg Thr Gly Leu Leu Gly Phe 
            740                 745                 750         


Ile Gly Pro Asp Asn Leu Val Phe Ile Val Gly Lys Leu Asp Gly Leu 
        755                 760                 765             


Met Val Thr Gly Val Arg Arg His Asn Ala Asp Asp Val Val Ala Thr 
    770                 775                 780                 


Ala Leu Ala Val Glu Pro Met Lys Phe Val Tyr Arg Gly Arg 
785                 790                 795             


<210>  3074
<211>  1576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIP2B__Homo_sapiens__NP_775873

<400>  3074

Met Ala Glu Arg Gly Leu Glu Pro Ser Pro Ala Ala Val Ala Ala Leu 
1               5                   10                  15      


Pro Pro Glu Val Arg Ala Gln Leu Ala Glu Leu Glu Leu Glu Leu Ser 
            20                  25                  30          


Glu Gly Asp Ile Thr Gln Lys Gly Tyr Glu Lys Lys Arg Ser Lys Leu 
        35                  40                  45              


Leu Ser Pro Tyr Ser Pro Gln Thr Gln Glu Thr Asp Ser Ala Val Gln 
    50                  55                  60                  


Lys Glu Leu Arg Asn Gln Thr Pro Ala Pro Ser Ala Ala Gln Thr Ser 
65                  70                  75                  80  


Ala Pro Ser Lys Tyr His Arg Thr Arg Ser Gly Gly Ala Arg Asp Glu 
                85                  90                  95      


Arg Tyr Arg Ser Asp Ile His Thr Glu Ala Val Gln Ala Ala Leu Ala 
            100                 105                 110         


Lys His Lys Glu Gln Lys Met Ala Leu Pro Met Pro Thr Lys Arg Arg 
        115                 120                 125             


Ser Thr Phe Val Gln Ser Pro Ala Asp Ala Cys Thr Pro Pro Asp Thr 
    130                 135                 140                 


Ser Ser Ala Ser Glu Asp Glu Gly Ser Leu Arg Arg Gln Ala Ala Leu 
145                 150                 155                 160 


Ser Ala Ala Leu Gln Gln Ser Leu Gln Asn Ala Glu Ser Trp Ile Asn 
                165                 170                 175     


Arg Ser Ile Gln Gly Ser Ser Thr Ser Ser Ser Ala Ser Ser Thr Leu 
            180                 185                 190         


Ser His Gly Glu Val Lys Gly Thr Ser Gly Ser Leu Ala Asp Val Phe 
        195                 200                 205             


Ala Asn Thr Arg Ile Glu Asn Phe Ser Ala Pro Pro Asp Val Thr Thr 
    210                 215                 220                 


Thr Thr Ser Ser Ser Ser Ser Ser Ser Ser Ile Arg Pro Ala Asn Ile 
225                 230                 235                 240 


Asp Leu Pro Pro Ser Gly Ile Val Lys Gly Met His Lys Gly Ser Asn 
                245                 250                 255     


Arg Ser Ser Leu Met Asp Thr Ala Asp Gly Val Pro Val Ser Ser Arg 
            260                 265                 270         


Val Ser Thr Lys Ile Gln Gln Leu Leu Asn Thr Leu Lys Arg Pro Lys 
        275                 280                 285             


Arg Pro Pro Leu Lys Glu Phe Phe Val Asp Asp Ser Glu Glu Ile Val 
    290                 295                 300                 


Glu Val Pro Gln Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Arg Gln 
305                 310                 315                 320 


Met Thr Pro Val Lys Gly Glu Pro Leu Gly Val Ile Cys Asn Trp Pro 
                325                 330                 335     


Pro Ala Leu Glu Ser Ala Leu Gln Arg Trp Gly Thr Thr Gln Ala Lys 
            340                 345                 350         


Cys Ser Cys Leu Thr Ala Leu Asp Met Thr Gly Lys Pro Val Tyr Thr 
        355                 360                 365             


Leu Thr Tyr Gly Lys Leu Trp Ser Arg Ser Leu Lys Leu Ala Tyr Thr 
    370                 375                 380                 


Leu Leu Asn Lys Leu Gly Thr Lys Asn Glu Pro Val Leu Lys Pro Gly 
385                 390                 395                 400 


Asp Arg Val Ala Leu Val Tyr Pro Asn Asn Asp Pro Val Met Phe Met 
                405                 410                 415     


Val Ala Phe Tyr Gly Cys Leu Leu Ala Glu Val Ile Pro Val Pro Ile 
            420                 425                 430         


Glu Val Pro Leu Thr Arg Lys Asp Ala Gly Gly Gln Gln Ile Gly Phe 
        435                 440                 445             


Leu Leu Gly Ser Cys Gly Ile Ala Leu Ala Leu Thr Ser Glu Val Cys 
    450                 455                 460                 


Leu Lys Gly Leu Pro Lys Thr Gln Asn Gly Glu Ile Val Gln Phe Lys 
465                 470                 475                 480 


Gly Trp Pro Arg Leu Lys Trp Val Val Thr Asp Ser Lys Tyr Leu Ser 
                485                 490                 495     


Lys Pro Pro Lys Asp Trp Gln Pro His Ile Ser Pro Ala Gly Thr Glu 
            500                 505                 510         


Pro Ala Tyr Ile Glu Tyr Lys Thr Ser Lys Glu Gly Ser Val Met Gly 
        515                 520                 525             


Val Thr Val Ser Arg Leu Ala Met Leu Ser His Cys Gln Ala Leu Ser 
    530                 535                 540                 


Gln Ala Cys Asn Tyr Ser Glu Gly Glu Thr Ile Val Asn Val Leu Asp 
545                 550                 555                 560 


Phe Lys Lys Asp Ala Gly Leu Trp His Gly Met Phe Ala Asn Val Met 
                565                 570                 575     


Asn Lys Met His Thr Ile Ser Val Pro Tyr Ser Val Met Lys Thr Cys 
            580                 585                 590         


Pro Leu Ser Trp Val Gln Arg Val His Ala His Lys Ala Lys Val Ala 
        595                 600                 605             


Leu Val Lys Cys Arg Asp Leu His Trp Ala Met Met Ala His Arg Asp 
    610                 615                 620                 


Gln Arg Asp Val Ser Leu Ser Ser Leu Arg Met Leu Ile Val Thr Asp 
625                 630                 635                 640 


Gly Ala Asn Pro Trp Ser Val Ser Ser Cys Asp Ala Phe Leu Ser Leu 
                645                 650                 655     


Phe Gln Ser His Gly Leu Lys Pro Glu Ala Ile Cys Pro Cys Ala Thr 
            660                 665                 670         


Ser Ala Glu Ala Met Thr Val Ala Ile Arg Arg Pro Gly Val Pro Gly 
        675                 680                 685             


Ala Pro Leu Pro Gly Arg Ala Ile Leu Ser Met Asn Gly Leu Ser Tyr 
    690                 695                 700                 


Gly Val Ile Arg Val Asn Thr Glu Asp Lys Asn Ser Ala Leu Thr Val 
705                 710                 715                 720 


Gln Asp Val Gly His Val Met Pro Gly Gly Met Met Cys Ile Val Lys 
                725                 730                 735     


Pro Asp Gly Pro Pro Gln Leu Cys Lys Thr Asp Glu Ile Gly Glu Ile 
            740                 745                 750         


Cys Val Ser Ser Arg Thr Gly Gly Met Met Tyr Phe Gly Leu Ala Gly 
        755                 760                 765             


Val Thr Lys Asn Thr Phe Glu Val Ile Pro Val Asn Ser Ala Gly Ser 
    770                 775                 780                 


Pro Val Gly Asp Val Pro Phe Ile Arg Ser Gly Leu Leu Gly Phe Val 
785                 790                 795                 800 


Gly Pro Gly Ser Leu Val Phe Val Val Gly Lys Met Asp Gly Leu Leu 
                805                 810                 815     


Met Val Ser Gly Arg Arg His Asn Ala Asp Asp Ile Val Ala Thr Gly 
            820                 825                 830         


Leu Ala Val Glu Ser Ile Lys Thr Val Tyr Arg Gly Arg Ile Ala Val 
        835                 840                 845             


Phe Ser Val Ser Val Phe Tyr Asp Glu Arg Ile Val Val Val Ala Glu 
    850                 855                 860                 


Gln Arg Pro Asp Ala Ser Glu Glu Asp Ser Phe Gln Trp Met Ser Arg 
865                 870                 875                 880 


Val Leu Gln Ala Ile Asp Ser Ile His Gln Val Gly Val Tyr Cys Leu 
                885                 890                 895     


Ala Leu Val Pro Ala Asn Thr Leu Pro Lys Thr Pro Leu Gly Gly Ile 
            900                 905                 910         


His Ile Ser Gln Thr Lys Gln Leu Phe Leu Glu Gly Ser Leu His Pro 
        915                 920                 925             


Cys Asn Ile Leu Met Cys Pro His Thr Cys Val Thr Asn Leu Pro Lys 
    930                 935                 940                 


Pro Arg Gln Lys Gln Pro Gly Val Gly Pro Ala Ser Val Met Val Gly 
945                 950                 955                 960 


Asn Leu Val Ala Gly Lys Arg Ile Ala Gln Ala Ala Gly Arg Asp Leu 
                965                 970                 975     


Gly Gln Ile Glu Glu Asn Asp Leu Val Arg Lys His Gln Phe Leu Ala 
            980                 985                 990         


Glu Ile Leu Gln Trp Arg Ala Gln  Ala Thr Pro Asp His  Val Leu Phe 
        995                 1000                 1005             


Met Leu  Leu Asn Ala Lys Gly  Thr Thr Val Cys Thr  Ala Ser Cys 
    1010                 1015                 1020             


Leu Gln  Leu His Lys Arg Ala  Glu Arg Ile Ala Ser  Val Leu Gly 
    1025                 1030                 1035             


Asp Lys  Gly His Leu Asn Ala  Gly Asp Asn Val Val  Leu Leu Tyr 
    1040                 1045                 1050             


Pro Pro  Gly Ile Glu Leu Ile  Ala Ala Phe Tyr Gly  Cys Leu Tyr 
    1055                 1060                 1065             


Ala Gly  Cys Ile Pro Val Thr  Val Arg Pro Pro His  Ala Gln Asn 
    1070                 1075                 1080             


Leu Thr  Ala Thr Leu Pro Thr  Val Arg Met Ile Val  Asp Val Ser 
    1085                 1090                 1095             


Lys Ala  Ala Cys Ile Leu Thr  Ser Gln Thr Leu Met  Arg Leu Leu 
    1100                 1105                 1110             


Arg Ser  Arg Glu Ala Ala Ala  Ala Val Asp Val Lys  Thr Trp Pro 
    1115                 1120                 1125             


Thr Ile  Ile Asp Thr Asp Asp  Leu Pro Arg Lys Arg  Leu Pro Gln 
    1130                 1135                 1140             


Leu Tyr  Lys Pro Pro Thr Pro  Glu Met Leu Ala Tyr  Leu Asp Phe 
    1145                 1150                 1155             


Ser Val  Ser Thr Thr Gly Met  Leu Thr Gly Val Lys  Met Ser His 
    1160                 1165                 1170             


Ser Ala  Val Asn Ala Leu Cys  Arg Ala Ile Lys Leu  Gln Cys Glu 
    1175                 1180                 1185             


Leu Tyr  Ser Ser Arg Gln Ile  Ala Ile Cys Leu Asp  Pro Tyr Cys 
    1190                 1195                 1200             


Gly Leu  Gly Phe Ala Leu Trp  Cys Leu Cys Ser Val  Tyr Ser Gly 
    1205                 1210                 1215             


His Gln  Ser Val Leu Ile Pro  Pro Met Glu Leu Glu  Asn Asn Leu 
    1220                 1225                 1230             


Phe Leu  Trp Leu Ser Thr Val  Asn Gln Tyr Lys Ile  Arg Asp Thr 
    1235                 1240                 1245             


Phe Cys  Ser Tyr Ser Val Met  Glu Leu Cys Thr Lys  Gly Leu Gly 
    1250                 1255                 1260             


Asn Gln  Val Glu Val Leu Lys  Thr Arg Gly Ile Asn  Leu Ser Cys 
    1265                 1270                 1275             


Val Arg  Thr Cys Val Val Val  Ala Glu Glu Arg Pro  Arg Val Ala 
    1280                 1285                 1290             


Leu Gln  Gln Ser Phe Ser Lys  Leu Phe Lys Asp Ile  Gly Leu Ser 
    1295                 1300                 1305             


Pro Arg  Ala Val Ser Thr Thr  Phe Gly Ser Arg Val  Asn Val Ala 
    1310                 1315                 1320             


Ile Cys  Leu Gln Gly Thr Ser  Gly Pro Asp Pro Thr  Thr Val Tyr 
    1325                 1330                 1335             


Val Asp  Leu Lys Ser Leu Arg  His Asp Arg Val Arg  Leu Val Glu 
    1340                 1345                 1350             


Arg Gly  Ala Pro Gln Ser Leu  Leu Leu Ser Glu Ser  Gly Lys Ile 
    1355                 1360                 1365             


Leu Pro  Gly Val Lys Val Val  Ile Val Asn Pro Glu  Thr Lys Gly 
    1370                 1375                 1380             


Pro Val  Gly Asp Ser His Leu  Gly Glu Ile Trp Val  Asn Ser Pro 
    1385                 1390                 1395             


His Thr  Ala Ser Gly Tyr Tyr  Thr Ile Tyr Asp Ser  Glu Thr Leu 
    1400                 1405                 1410             


Gln Ala  Asp His Phe Asn Thr  Arg Leu Ser Phe Gly  Asp Ala Ala 
    1415                 1420                 1425             


Gln Thr  Leu Trp Ala Arg Thr  Gly Tyr Leu Gly Phe  Val Arg Arg 
    1430                 1435                 1440             


Thr Glu  Leu Thr Ala Ala Thr  Gly Glu Arg His Asp  Ala Leu Tyr 
    1445                 1450                 1455             


Val Val  Gly Ala Leu Asp Glu  Thr Leu Glu Leu Arg  Gly Leu Arg 
    1460                 1465                 1470             


Tyr His  Pro Ile Asp Ile Glu  Thr Ser Val Ser Arg  Ile His Arg 
    1475                 1480                 1485             


Ser Ile  Ala Glu Cys Ala Val  Phe Thr Trp Thr Asn  Leu Leu Val 
    1490                 1495                 1500             


Val Val  Val Glu Leu Cys Gly  Ser Glu Gln Glu Ala  Leu Asp Leu 
    1505                 1510                 1515             


Val Pro  Leu Val Thr Asn Val  Val Leu Glu Glu His  Tyr Leu Ile 
    1520                 1525                 1530             


Val Gly  Val Val Val Val Val  Asp Pro Gly Val Ile  Pro Ile Asn 
    1535                 1540                 1545             


Ser Arg  Gly Glu Lys Gln Arg  Met His Leu Arg Asp  Ser Phe Leu 
    1550                 1555                 1560             


Ala Asp  Gln Leu Asp Pro Ile  Tyr Val Ala Tyr Asn  Met 
    1565                 1570                 1575     


<210>  3075
<211>  1556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIP2C__Homo_sapiens__NP_055789

<400>  3075

Met Ala Asp Arg Ser Leu Glu Gly Met Ala Leu Pro Leu Glu Val Arg 
1               5                   10                  15      


Ala Arg Leu Ala Glu Leu Glu Leu Glu Leu Ser Glu Gly Asp Ile Thr 
            20                  25                  30          


Gln Lys Gly Tyr Glu Lys Lys Arg Ser Lys Leu Ile Gly Ala Tyr Leu 
        35                  40                  45              


Pro Gln Pro Pro Arg Val Asp Gln Ala Leu Pro Gln Glu Arg Arg Ala 
    50                  55                  60                  


Pro Val Thr Pro Ser Ser Ala Ser Arg Tyr His Arg Arg Arg Ser Ser 
65                  70                  75                  80  


Gly Ser Arg Asp Glu Arg Tyr Arg Ser Asp Val His Thr Glu Ala Val 
                85                  90                  95      


Gln Ala Ala Leu Ala Lys His Lys Glu Arg Lys Met Ala Val Pro Met 
            100                 105                 110         


Pro Ser Lys Arg Arg Ser Leu Val Val Gln Thr Ser Met Asp Ala Tyr 
        115                 120                 125             


Thr Pro Pro Asp Thr Ser Ser Gly Ser Glu Asp Glu Gly Ser Val Gln 
    130                 135                 140                 


Gly Asp Ser Gln Gly Thr Pro Thr Ser Ser Gln Gly Ser Ile Asn Met 
145                 150                 155                 160 


Glu His Trp Ile Ser Gln Ala Ile His Gly Ser Thr Thr Ser Thr Thr 
                165                 170                 175     


Ser Ser Ser Ser Thr Gln Ser Gly Gly Ser Gly Ala Ala His Arg Leu 
            180                 185                 190         


Ala Asp Val Met Ala Gln Thr His Ile Glu Asn His Ser Ala Pro Pro 
        195                 200                 205             


Asp Val Thr Thr Tyr Thr Ser Glu His Ser Ile Gln Val Glu Arg Pro 
    210                 215                 220                 


Gln Gly Ser Thr Gly Ser Arg Thr Ala Pro Lys Tyr Gly Asn Ala Glu 
225                 230                 235                 240 


Leu Met Glu Thr Gly Asp Gly Val Pro Val Ser Ser Arg Val Ser Ala 
                245                 250                 255     


Lys Ile Gln Gln Leu Val Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro 
            260                 265                 270         


Leu Arg Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln 
        275                 280                 285             


Gln Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ala Gln Met Leu Ala 
    290                 295                 300                 


Met Arg Gly Glu Gln Leu Gly Val Val Thr Asn Trp Pro Pro Ser Leu 
305                 310                 315                 320 


Glu Ala Ala Leu Gln Arg Trp Gly Thr Ile Ser Pro Lys Ala Pro Cys 
                325                 330                 335     


Leu Thr Thr Met Asp Thr Asn Gly Lys Pro Leu Tyr Ile Leu Thr Tyr 
            340                 345                 350         


Gly Lys Leu Trp Thr Arg Ser Met Lys Val Ala Tyr Ser Ile Leu His 
        355                 360                 365             


Lys Leu Gly Thr Lys Gln Glu Pro Met Val Arg Pro Gly Asp Arg Val 
    370                 375                 380                 


Ala Leu Val Phe Pro Asn Asn Asp Pro Ala Ala Phe Met Ala Ala Phe 
385                 390                 395                 400 


Tyr Gly Cys Leu Leu Ala Glu Val Val Pro Val Pro Ile Glu Val Pro 
                405                 410                 415     


Leu Thr Arg Lys Asp Ala Gly Ser Gln Gln Ile Gly Phe Leu Leu Gly 
            420                 425                 430         


Ser Cys Gly Val Thr Val Ala Leu Thr Ser Asp Ala Cys His Lys Gly 
        435                 440                 445             


Leu Pro Lys Ser Pro Thr Gly Glu Ile Pro Gln Phe Lys Gly Trp Pro 
    450                 455                 460                 


Lys Leu Leu Trp Phe Val Thr Glu Ser Lys His Leu Ser Lys Pro Pro 
465                 470                 475                 480 


Arg Asp Trp Phe Pro His Ile Lys Asp Ala Asn Asn Asp Thr Ala Tyr 
                485                 490                 495     


Ile Glu Tyr Lys Thr Cys Lys Asp Gly Ser Val Leu Gly Val Thr Val 
            500                 505                 510         


Thr Arg Thr Ala Leu Leu Thr His Cys Gln Ala Leu Thr Gln Ala Cys 
        515                 520                 525             


Gly Tyr Thr Glu Ala Glu Thr Ile Val Asn Val Leu Asp Phe Lys Lys 
    530                 535                 540                 


Asp Val Gly Leu Trp His Gly Ile Leu Thr Ser Val Met Asn Met Met 
545                 550                 555                 560 


His Val Ile Ser Ile Pro Tyr Ser Leu Met Lys Val Asn Pro Leu Ser 
                565                 570                 575     


Trp Ile Gln Lys Val Cys Gln Tyr Lys Ala Lys Val Ala Cys Val Lys 
            580                 585                 590         


Ser Arg Asp Met His Trp Ala Leu Val Ala His Arg Asp Gln Arg Asp 
        595                 600                 605             


Ile Asn Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn 
    610                 615                 620                 


Pro Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser 
625                 630                 635                 640 


Lys Gly Leu Arg Gln Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu 
                645                 650                 655     


Ala Leu Thr Val Ala Ile Arg Arg Pro Thr Asp Asp Ser Asn Gln Pro 
            660                 665                 670         


Pro Gly Arg Gly Val Leu Ser Met His Gly Leu Thr Tyr Gly Val Ile 
        675                 680                 685             


Arg Val Asp Ser Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val 
    690                 695                 700                 


Gly Leu Val Met Pro Gly Ala Ile Met Cys Ser Val Lys Pro Asp Gly 
705                 710                 715                 720 


Val Pro Gln Leu Cys Arg Thr Asp Glu Ile Gly Glu Leu Cys Val Cys 
                725                 730                 735     


Ala Val Ala Thr Gly Thr Ser Tyr Tyr Gly Leu Ser Gly Met Thr Lys 
            740                 745                 750         


Asn Thr Phe Glu Val Phe Pro Met Thr Ser Ser Gly Ala Pro Ile Ser 
        755                 760                 765             


Glu Tyr Pro Phe Ile Arg Thr Gly Leu Leu Gly Phe Val Gly Pro Gly 
    770                 775                 780                 


Gly Leu Val Phe Val Val Gly Lys Met Asp Gly Leu Met Val Val Ser 
785                 790                 795                 800 


Gly Arg Arg His Asn Ala Asp Asp Ile Val Ala Thr Ala Leu Ala Val 
                805                 810                 815     


Glu Pro Met Lys Phe Val Tyr Arg Gly Arg Ile Ala Val Phe Ser Val 
            820                 825                 830         


Thr Val Leu His Asp Glu Arg Ile Val Ile Val Ala Glu Gln Arg Pro 
        835                 840                 845             


Asp Ser Thr Glu Glu Asp Ser Phe Gln Trp Met Ser Arg Val Leu Gln 
    850                 855                 860                 


Ala Ile Asp Ser Ile His Gln Val Gly Val Tyr Cys Leu Ala Leu Val 
865                 870                 875                 880 


Pro Ala Asn Thr Leu Pro Lys Thr Pro Leu Gly Gly Ile His Leu Ser 
                885                 890                 895     


Glu Thr Lys Gln Leu Phe Leu Glu Gly Ser Leu His Pro Cys Asn Val 
            900                 905                 910         


Leu Met Cys Pro His Thr Cys Val Thr Asn Leu Pro Lys Pro Arg Gln 
        915                 920                 925             


Lys Gln Pro Glu Ile Gly Pro Ala Ser Val Met Val Gly Asn Leu Val 
    930                 935                 940                 


Ser Gly Lys Arg Ile Ala Gln Ala Ser Gly Arg Asp Leu Gly Gln Ile 
945                 950                 955                 960 


Glu Asp Asn Asp Gln Ala Arg Lys Phe Leu Phe Leu Ser Glu Val Leu 
                965                 970                 975     


Gln Trp Arg Ala Gln Thr Thr Pro Asp His Ile Leu Tyr Thr Leu Leu 
            980                 985                 990         


Asn Cys Arg Gly Ala Ile Ala Asn  Ser Leu Thr Cys Val  Gln Leu His 
        995                 1000                 1005             


Lys Arg  Ala Glu Lys Ile Ala  Val Met Leu Met Glu  Arg Gly His 
    1010                 1015                 1020             


Leu Gln  Asp Gly Asp His Val  Ala Leu Val Tyr Pro  Pro Gly Ile 
    1025                 1030                 1035             


Asp Leu  Ile Ala Ala Phe Tyr  Gly Cys Leu Tyr Ala  Gly Cys Val 
    1040                 1045                 1050             


Pro Ile  Thr Val Arg Pro Pro  His Pro Gln Asn Ile  Ala Thr Thr 
    1055                 1060                 1065             


Leu Pro  Thr Val Lys Met Ile  Val Glu Val Ser Arg  Ser Ala Cys 
    1070                 1075                 1080             


Leu Met  Thr Thr Gln Leu Ile  Cys Lys Leu Leu Arg  Ser Arg Glu 
    1085                 1090                 1095             


Ala Ala  Ala Ala Val Asp Val  Arg Thr Trp Pro Leu  Ile Leu Asp 
    1100                 1105                 1110             


Thr Asp  Asp Leu Pro Lys Lys  Arg Pro Ala Gln Ile  Cys Lys Pro 
    1115                 1120                 1125             


Cys Asn  Pro Asp Thr Leu Ala  Tyr Leu Asp Phe Ser  Val Ser Thr 
    1130                 1135                 1140             


Thr Gly  Met Leu Ala Gly Val  Lys Met Ser His Ala  Ala Thr Ser 
    1145                 1150                 1155             


Ala Phe  Cys Arg Ser Ile Lys  Leu Gln Cys Glu Leu  Tyr Pro Ser 
    1160                 1165                 1170             


Arg Glu  Val Ala Ile Cys Leu  Asp Pro Tyr Cys Gly  Leu Gly Phe 
    1175                 1180                 1185             


Val Leu  Trp Cys Leu Cys Ser  Val Tyr Ser Gly His  Gln Ser Ile 
    1190                 1195                 1200             


Leu Ile  Pro Pro Ser Glu Leu  Glu Thr Asn Pro Ala  Leu Trp Leu 
    1205                 1210                 1215             


Leu Ala  Val Ser Gln Tyr Lys  Val Arg Asp Thr Phe  Cys Ser Tyr 
    1220                 1225                 1230             


Ser Val  Met Glu Leu Cys Thr  Lys Gly Leu Gly Ser  Gln Thr Glu 
    1235                 1240                 1245             


Ser Leu  Lys Ala Arg Gly Leu  Asp Leu Ser Arg Val  Arg Thr Cys 
    1250                 1255                 1260             


Val Val  Val Ala Glu Glu Arg  Pro Arg Ile Ala Leu  Thr Gln Ser 
    1265                 1270                 1275             


Phe Ser  Lys Leu Phe Lys Asp  Leu Gly Leu His Pro  Arg Ala Val 
    1280                 1285                 1290             


Ser Thr  Ser Phe Gly Cys Arg  Val Asn Leu Ala Ile  Cys Leu Gln 
    1295                 1300                 1305             


Gly Thr  Ser Gly Pro Asp Pro  Thr Thr Val Tyr Val  Asp Met Arg 
    1310                 1315                 1320             


Ala Leu  Arg His Asp Arg Val  Arg Leu Val Glu Arg  Gly Ser Pro 
    1325                 1330                 1335             


His Ser  Leu Pro Leu Met Glu  Ser Gly Lys Ile Leu  Pro Gly Val 
    1340                 1345                 1350             


Arg Ile  Ile Ile Ala Asn Pro  Glu Thr Lys Gly Pro  Leu Gly Asp 
    1355                 1360                 1365             


Ser His  Leu Gly Glu Ile Trp  Val His Ser Ala His  Asn Ala Ser 
    1370                 1375                 1380             


Gly Tyr  Phe Thr Ile Tyr Gly  Asp Glu Ser Leu Gln  Ser Asp His 
    1385                 1390                 1395             


Phe Asn  Ser Arg Leu Ser Phe  Gly Asp Thr Gln Thr  Ile Trp Ala 
    1400                 1405                 1410             


Arg Thr  Gly Tyr Leu Gly Phe  Leu Arg Arg Thr Glu  Leu Thr Asp 
    1415                 1420                 1425             


Ala Asn  Gly Glu Arg His Asp  Ala Leu Tyr Val Val  Gly Ala Leu 
    1430                 1435                 1440             


Asp Glu  Ala Met Glu Leu Arg  Gly Met Arg Tyr His  Pro Ile Asp 
    1445                 1450                 1455             


Ile Glu  Thr Ser Val Ile Arg  Ala His Lys Ser Val  Thr Glu Cys 
    1460                 1465                 1470             


Ala Val  Phe Thr Trp Thr Asn  Leu Leu Val Val Val  Val Glu Leu 
    1475                 1480                 1485             


Asp Gly  Ser Glu Gln Glu Ala  Leu Asp Leu Val Pro  Leu Val Thr 
    1490                 1495                 1500             


Asn Val  Val Leu Glu Glu His  Tyr Leu Ile Val Gly  Val Val Val 
    1505                 1510                 1515             


Val Val  Asp Ile Gly Val Ile  Pro Ile Asn Ser Arg  Gly Glu Lys 
    1520                 1525                 1530             


Gln Arg  Met His Leu Arg Asp  Gly Phe Leu Ala Asp  Gln Leu Asp 
    1535                 1540                 1545             


Pro Ile  Tyr Val Ala Tyr Asn  Met 
    1550                 1555     


<210>  3076
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIRAS1__Homo_sapiens__NP_660156

<400>  3076

Met Pro Glu Gln Ser Asn Asp Tyr Arg Val Val Val Phe Gly Ala Gly 
1               5                   10                  15      


Gly Val Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Thr Phe 
            20                  25                  30          


Arg Asp Thr Tyr Ile Pro Thr Ile Glu Asp Thr Tyr Arg Gln Val Ile 
        35                  40                  45              


Ser Cys Asp Lys Ser Val Cys Thr Leu Gln Ile Thr Asp Thr Thr Gly 
    50                  55                  60                  


Ser His Gln Phe Pro Ala Met Gln Arg Leu Ser Ile Ser Lys Gly His 
65                  70                  75                  80  


Ala Phe Ile Leu Val Phe Ser Val Thr Ser Lys Gln Ser Leu Glu Glu 
                85                  90                  95      


Leu Gly Pro Ile Tyr Lys Leu Ile Val Gln Ile Lys Gly Ser Val Glu 
            100                 105                 110         


Asp Ile Pro Val Met Leu Val Gly Asn Lys Cys Asp Glu Thr Gln Arg 
        115                 120                 125             


Glu Val Asp Thr Arg Glu Ala Gln Ala Val Ala Gln Glu Trp Lys Cys 
    130                 135                 140                 


Ala Phe Met Glu Thr Ser Ala Lys Met Asn Tyr Asn Val Lys Glu Leu 
145                 150                 155                 160 


Phe Gln Glu Leu Leu Thr Leu Glu Thr Arg Arg Asn Met Ser Leu Asn 
                165                 170                 175     


Ile Asp Gly Lys Arg Ser Gly Lys Gln Lys Arg Thr Asp Arg Val Lys 
            180                 185                 190         


Gly Lys Cys Thr Leu Met 
        195             


<210>  3077
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIRAS2__Homo_sapiens__NP_060064

<400>  3077

Met Pro Glu Gln Ser Asn Asp Tyr Arg Val Ala Val Phe Gly Ala Gly 
1               5                   10                  15      


Gly Val Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Thr Phe 
            20                  25                  30          


Arg Glu Ser Tyr Ile Pro Thr Val Glu Asp Thr Tyr Arg Gln Val Ile 
        35                  40                  45              


Ser Cys Asp Lys Ser Ile Cys Thr Leu Gln Ile Thr Asp Thr Thr Gly 
    50                  55                  60                  


Ser His Gln Phe Pro Ala Met Gln Arg Leu Ser Ile Ser Lys Gly His 
65                  70                  75                  80  


Ala Phe Ile Leu Val Tyr Ser Ile Thr Ser Arg Gln Ser Leu Glu Glu 
                85                  90                  95      


Leu Lys Pro Ile Tyr Glu Gln Ile Cys Glu Ile Lys Gly Asp Val Glu 
            100                 105                 110         


Ser Ile Pro Ile Met Leu Val Gly Asn Lys Cys Asp Glu Ser Pro Ser 
        115                 120                 125             


Arg Glu Val Gln Ser Ser Glu Ala Glu Ala Leu Ala Arg Thr Trp Lys 
    130                 135                 140                 


Cys Ala Phe Met Glu Thr Ser Ala Lys Leu Asn His Asn Val Lys Glu 
145                 150                 155                 160 


Leu Phe Gln Glu Leu Leu Asn Leu Glu Lys Arg Arg Thr Val Ser Leu 
                165                 170                 175     


Gln Ile Asp Gly Lys Lys Ser Lys Gln Gln Lys Arg Lys Glu Lys Leu 
            180                 185                 190         


Lys Gly Lys Cys Val Ile Met 
        195                 


<210>  3078
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIRC1__Homo_sapiens__XP_011508847

<400>  3078

Met Pro Glu Ala His Met Gln Pro Ala Lys Leu Gln Thr Ser Leu Pro 
1               5                   10                  15      


Thr Thr Asp His Gly Ser Lys Lys Pro Val Ser Cys Tyr Leu Pro Pro 
            20                  25                  30          


Leu Ser Asn Ala His Pro Met Cys Ile Glu Val Gln Asn Ala Gln Asn 
        35                  40                  45              


Cys Ser Ser Ala Ala Ala Thr Leu Glu Pro Ser Ile Ile Ser Asp Thr 
    50                  55                  60                  


Cys Phe Tyr Lys Pro Ile Thr Lys Asp Gln Leu Ser Ser Arg Ser Glu 
65                  70                  75                  80  


Leu Asn Thr Val Arg Leu Lys Cys Leu Asn Ser Leu Arg Gly Trp Lys 
                85                  90                  95      


Ile Leu Asn Gln Leu Ser Leu Thr 
            100                 


<210>  3079
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIRC2__Homo_sapiens__NP_116228

<400>  3079

Met Gly Ser Arg Trp Ser Ser Glu Glu Glu Arg Gln Pro Leu Leu Gly 
1               5                   10                  15      


Pro Gly Leu Gly Pro Gly Leu Gly Ala Ser Trp Arg Ser Arg Glu Ala 
            20                  25                  30          


Ala Ala Ala Ala Leu Pro Ala Ala Val Pro Gly Pro Gly Arg Val Tyr 
        35                  40                  45              


Gly Arg Arg Trp Leu Val Leu Leu Leu Phe Ser Leu Leu Ala Phe Val 
    50                  55                  60                  


Gln Gly Leu Val Trp Asn Thr Trp Gly Pro Ile Gln Asn Ser Ala Arg 
65                  70                  75                  80  


Gln Ala Tyr Gly Phe Ser Ser Trp Asp Ile Ala Leu Leu Val Leu Trp 
                85                  90                  95      


Gly Pro Ile Gly Phe Leu Pro Cys Phe Ala Phe Met Trp Leu Leu Asp 
            100                 105                 110         


Lys Arg Gly Leu Arg Ile Thr Val Leu Leu Thr Ser Phe Leu Met Val 
        115                 120                 125             


Leu Gly Thr Gly Leu Arg Cys Ile Pro Ile Ser Asp Leu Ile Leu Lys 
    130                 135                 140                 


Arg Arg Leu Ile His Gly Gly Gln Met Leu Asn Gly Leu Ala Gly Pro 
145                 150                 155                 160 


Thr Val Met Asn Ala Ala Pro Phe Leu Ser Thr Thr Trp Phe Ser Ala 
                165                 170                 175     


Asp Glu Arg Ala Thr Ala Thr Ala Ile Ala Ser Met Leu Ser Tyr Leu 
            180                 185                 190         


Gly Gly Ala Cys Ala Phe Leu Val Gly Pro Leu Val Val Pro Ala Pro 
        195                 200                 205             


Asn Gly Thr Ser Pro Leu Leu Ala Ala Glu Ser Ser Arg Ala His Ile 
    210                 215                 220                 


Lys Asp Arg Ile Glu Ala Val Leu Tyr Ala Glu Phe Gly Val Val Cys 
225                 230                 235                 240 


Leu Ile Phe Ser Ala Thr Leu Ala Tyr Phe Pro Pro Arg Pro Pro Leu 
                245                 250                 255     


Pro Pro Ser Val Ala Ala Ala Ser Gln Arg Leu Ser Tyr Arg Arg Ser 
            260                 265                 270         


Val Cys Arg Leu Leu Ser Asn Phe Arg Phe Leu Met Ile Ala Leu Ala 
        275                 280                 285             


Tyr Ala Ile Pro Leu Gly Val Phe Ala Gly Trp Ser Gly Val Leu Asp 
    290                 295                 300                 


Leu Ile Leu Thr Pro Ala His Val Ser Gln Val Asp Ala Gly Trp Ile 
305                 310                 315                 320 


Gly Phe Trp Ser Ile Val Gly Gly Cys Val Val Gly Ile Ala Met Ala 
                325                 330                 335     


Arg Phe Ala Asp Phe Ile Arg Gly Met Leu Lys Leu Ile Leu Leu Leu 
            340                 345                 350         


Leu Phe Ser Gly Ala Thr Leu Ser Ser Thr Trp Phe Thr Leu Thr Cys 
        355                 360                 365             


Leu Asn Ser Ile Thr His Leu Pro Leu Thr Thr Val Thr Leu Tyr Ala 
    370                 375                 380                 


Ser Cys Ile Leu Leu Gly Val Phe Leu Asn Ser Ser Val Pro Ile Phe 
385                 390                 395                 400 


Phe Glu Leu Phe Val Glu Thr Val Tyr Pro Val Pro Glu Gly Ile Thr 
                405                 410                 415     


Cys Gly Val Val Thr Phe Leu Ser Asn Met Phe Met Gly Val Leu Leu 
            420                 425                 430         


Phe Phe Leu Thr Phe Tyr His Thr Glu Leu Ser Trp Phe Asn Trp Cys 
        435                 440                 445             


Leu Pro Gly Ser Cys Leu Leu Ser Leu Leu Leu Ile Leu Cys Phe Arg 
    450                 455                 460                 


Glu Ser Tyr Asp Arg Leu Tyr Leu Asp Val Val Val Ser Val 
465                 470                 475             


<210>  3080
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIS3__Homo_sapiens__NP_001121698

<400>  3080

Met Leu Lys Ser Lys Thr Phe Leu Lys Lys Thr Arg Ala Gly Gly Val 
1               5                   10                  15      


Met Lys Ile Val Arg Glu His Tyr Leu Arg Asp Asp Ile Gly Cys Gly 
            20                  25                  30          


Ala Pro Gly Cys Ala Ala Cys Gly Gly Ala His Glu Gly Pro Ala Leu 
        35                  40                  45              


Glu Pro Gln Pro Gln Asp Pro Ala Ser Ser Val Cys Pro Gln Pro His 
    50                  55                  60                  


Tyr Leu Leu Pro Asp Thr Asn Val Leu Leu His Gln Ile Val Ser Ala 
65                  70                  75                  80  


Trp Arg Pro Gly Thr Trp Ala Ser Val Ala Ser Ser Leu Arg Leu Pro 
                85                  90                  95      


Gly Ser Leu Glu Thr Tyr Val Glu Gln Glu Gln Gly Glu Asn Ala Asn 
            100                 105                 110         


Asp Arg Asn Asp Arg Ala Ile Arg Val Ala Ala Lys Trp Tyr Asn Glu 
        115                 120                 125             


His Leu Lys Lys Met Ser Ala Asp Asn Gln Leu Gln Val Ile Phe Ile 
    130                 135                 140                 


Thr Asn Asp Arg Arg Asn Lys Glu Lys Ala Ile Glu Glu Gly Ile Pro 
145                 150                 155                 160 


Ala Phe Thr Cys Glu Glu Tyr Val Lys Ser Leu Thr Ala Asn Pro Glu 
                165                 170                 175     


Leu Ile Asp Arg Leu Ala Cys Leu Ser Glu Glu Gly Asn Glu Ile Glu 
            180                 185                 190         


Ser Gly Lys Ile Ile Phe Ser Glu His Leu Pro Leu Ser Lys Leu Gln 
        195                 200                 205             


Gln Gly Ile Lys Ser Gly Thr Tyr Leu Gln Gly Thr Phe Arg Ala Ser 
    210                 215                 220                 


Arg Glu Asn Tyr Leu Glu Ala Thr Val Trp Ile His Gly Asp Asn Glu 
225                 230                 235                 240 


Glu Asn Lys Glu Ile Ile Leu Gln Gly Leu Lys His Leu Asn Arg Ala 
                245                 250                 255     


Val His Glu Asp Ile Val Ala Val Glu Leu Leu Pro Lys Ser Gln Trp 
            260                 265                 270         


Val Ala Pro Ser Ser Val Val Leu His Asp Glu Gly Gln Asn Glu Glu 
        275                 280                 285             


Asp Val Glu Lys Glu Glu Glu Thr Glu Arg Met Leu Lys Thr Ala Val 
    290                 295                 300                 


Ser Glu Lys Met Leu Lys Pro Thr Gly Arg Val Val Gly Ile Ile Lys 
305                 310                 315                 320 


Arg Asn Trp Arg Pro Tyr Cys Gly Met Leu Ser Lys Ser Asp Ile Lys 
                325                 330                 335     


Glu Ser Arg Arg His Leu Phe Thr Pro Ala Asp Lys Arg Ile Pro Arg 
            340                 345                 350         


Ile Arg Ile Glu Thr Arg Gln Ala Ser Thr Leu Glu Gly Arg Arg Ile 
        355                 360                 365             


Ile Val Ala Ile Asp Gly Trp Pro Arg Asn Ser Arg Tyr Pro Asn Gly 
    370                 375                 380                 


His Phe Val Arg Asn Leu Gly Asp Val Gly Glu Lys Glu Thr Glu Thr 
385                 390                 395                 400 


Glu Val Leu Leu Leu Glu His Asp Val Pro His Gln Pro Phe Ser Gln 
                405                 410                 415     


Ala Val Leu Ser Phe Leu Pro Lys Met Pro Trp Ser Ile Thr Glu Lys 
            420                 425                 430         


Asp Met Lys Asn Arg Glu Asp Leu Arg His Leu Cys Ile Cys Ser Val 
        435                 440                 445             


Asp Pro Pro Gly Cys Thr Asp Ile Asp Asp Ala Leu His Cys Arg Glu 
    450                 455                 460                 


Leu Glu Asn Gly Asn Leu Glu Val Gly Val His Ile Ala Asp Val Ser 
465                 470                 475                 480 


His Phe Ile Arg Pro Gly Asn Ala Leu Asp Gln Glu Ser Ala Arg Arg 
                485                 490                 495     


Gly Thr Thr Val Tyr Leu Cys Glu Lys Arg Ile Asp Met Val Pro Glu 
            500                 505                 510         


Leu Leu Ser Ser Asn Leu Cys Ser Leu Lys Cys Asp Val Asp Arg Leu 
        515                 520                 525             


Ala Phe Ser Cys Ile Trp Glu Met Asn His Asn Ala Glu Ile Leu Lys 
    530                 535                 540                 


Thr Lys Phe Thr Lys Ser Val Ile Asn Ser Lys Ala Ser Leu Thr Tyr 
545                 550                 555                 560 


Ala Glu Ala Gln Leu Arg Ile Asp Ser Ala Asn Met Asn Asp Asp Ile 
                565                 570                 575     


Thr Thr Ser Leu Arg Gly Leu Asn Lys Leu Ala Lys Ile Leu Lys Lys 
            580                 585                 590         


Arg Arg Ile Glu Lys Gly Ala Leu Thr Leu Ser Ser Pro Glu Val Arg 
        595                 600                 605             


Phe His Met Asp Ser Glu Thr His Asp Pro Ile Asp Leu Gln Thr Lys 
    610                 615                 620                 


Glu Leu Arg Glu Thr Asn Ser Met Val Glu Glu Phe Met Leu Leu Ala 
625                 630                 635                 640 


Asn Ile Ser Val Ala Lys Lys Ile His Glu Glu Phe Ser Glu His Ala 
                645                 650                 655     


Leu Leu Arg Lys His Pro Ala Pro Pro Pro Ser Asn Tyr Glu Ile Leu 
            660                 665                 670         


Val Lys Ala Ala Arg Ser Arg Asn Leu Glu Ile Lys Thr Asp Thr Ala 
        675                 680                 685             


Lys Ser Leu Ala Glu Ser Leu Asp Gln Ala Glu Ser Pro Thr Phe Pro 
    690                 695                 700                 


Tyr Leu Asn Thr Leu Leu Arg Ile Leu Ala Thr Arg Cys Met Met Gln 
705                 710                 715                 720 


Ala Val Tyr Phe Cys Ser Gly Met Asp Asn Asp Phe His His Tyr Gly 
                725                 730                 735     


Leu Ala Ser Pro Ile Tyr Thr His Phe Thr Ser Pro Ile Arg Arg Tyr 
            740                 745                 750         


Ala Asp Val Ile Val His Arg Leu Leu Ala Val Ala Ile Gly Ala Asp 
        755                 760                 765             


Cys Thr Tyr Pro Glu Leu Thr Asp Lys His Lys Leu Ala Asp Ile Cys 
    770                 775                 780                 


Lys Asn Leu Asn Phe Arg His Lys Met Ala Gln Tyr Ala Gln Arg Ala 
785                 790                 795                 800 


Ser Val Ala Phe His Thr Gln Leu Phe Phe Lys Ser Lys Gly Ile Val 
                805                 810                 815     


Ser Glu Glu Ala Tyr Ile Leu Phe Val Arg Lys Asn Ala Ile Val Val 
            820                 825                 830         


Leu Ile Pro Lys Tyr Gly Leu Glu Gly Thr Val Phe Phe Glu Glu Lys 
        835                 840                 845             


Asp Lys Pro Asn Pro Gln Leu Ile Tyr Asp Asp Glu Ile Pro Ser Leu 
    850                 855                 860                 


Lys Ile Glu Asp Thr Val Phe His Val Phe Asp Lys Val Lys Val Lys 
865                 870                 875                 880 


Ile Met Leu Asp Ser Ser Asn Leu Gln His Gln Lys Ile Arg Met Ser 
                885                 890                 895     


Leu Val Glu Pro Gln Ile Pro Gly Ile Ser Ile Pro Thr Asp Thr Ser 
            900                 905                 910         


Asn Met Asp Leu Asn Gly Pro Lys Lys Lys Lys Met Lys Leu Gly Lys 
        915                 920                 925             


<210>  3081
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIS3L2__Homo_sapiens__NP_001244210

<400>  3081

Met Ser His Pro Asp Tyr Arg Met Asn Leu Arg Pro Leu Gly Thr Pro 
1               5                   10                  15      


Arg Gly Val Ser Ala Val Ala Gly Pro His Asp Ile Gly Ala Ser Pro 
            20                  25                  30          


Gly Asp Lys Lys Ser Lys Asn Arg Ser Thr Arg Gly Lys Lys Lys Ser 
        35                  40                  45              


Ile Phe Glu Thr Tyr Met Ser Lys Glu Asp Val Ser Glu Gly Leu Lys 
    50                  55                  60                  


Arg Gly Thr Leu Ile Gln Gly Val Leu Arg Ile Asn Pro Lys Lys Phe 
65                  70                  75                  80  


His Glu Ala Phe Ile Pro Ser Pro Asp Gly Asp Arg Asp Ile Phe Ile 
                85                  90                  95      


Asp Gly Val Val Ala Arg Asn Arg Ala Leu Asn Gly Asp Leu Val Val 
            100                 105                 110         


Val Lys Leu Leu Pro Glu Glu His Trp Lys Val Val Lys Pro Glu Ser 
        115                 120                 125             


Asn Asp Lys Glu Thr Glu Ala Ala Tyr Glu Ser Asp Ile Pro Glu Glu 
    130                 135                 140                 


Leu Cys Gly His His Leu Pro Gln Gln Ser Leu Lys Ser Tyr Asn Asp 
145                 150                 155                 160 


Ser Pro Asp Val Ile Val Glu Ala Gln Phe Asp Gly Ser Asp Ser Glu 
                165                 170                 175     


Asp Gly His Gly Ile Thr Gln Asn Val Leu Val Asp Gly Val Lys Lys 
            180                 185                 190         


Leu Ser Val Cys Val Ser Glu Lys Gly Arg Glu Asp Gly Asp Ala Pro 
        195                 200                 205             


Val Thr Lys Asp Glu Thr Thr Cys Ile Ser Gln Asp Thr Arg Ala Leu 
    210                 215                 220                 


Ser Glu Lys Ser Leu Gln Arg Ser Ala Lys Val Val Tyr Ile Leu Glu 
225                 230                 235                 240 


Lys Lys His Ser Arg Ala Ala Thr Gly Phe Leu Lys Leu Leu Ala Asp 
                245                 250                 255     


Lys Asn Ser Glu Leu Phe Arg Lys Tyr Ala Leu Phe Ser Pro Ser Asp 
            260                 265                 270         


His Arg Val Pro Arg Ile Tyr Val Pro Leu Lys Asp Cys Pro Gln Asp 
        275                 280                 285             


Phe Val Ala Arg Pro Lys Asp Tyr Ala Asn Thr Leu Phe Ile Cys Arg 
    290                 295                 300                 


Ile Val Asp Trp Lys Glu Asp Cys Asn Phe Ala Leu Gly Gln Leu Ala 
305                 310                 315                 320 


Lys Ser Leu Gly Gln Ala Gly Glu Ile Glu Pro Glu Thr Glu Gly Ile 
                325                 330                 335     


Leu Thr Glu Tyr Gly Val Asp Phe Ser Asp Phe Ser Ser Glu Val Leu 
            340                 345                 350         


Glu Cys Leu Pro Gln Gly Leu Pro Trp Thr Ile Pro Pro Glu Glu Phe 
        355                 360                 365             


Ser Lys Arg Arg Asp Leu Arg Lys Asp Cys Ile Phe Thr Ile Asp Pro 
    370                 375                 380                 


Ser Thr Ala Arg Asp Leu Asp Asp Ala Leu Ser Cys Lys Pro Leu Ala 
385                 390                 395                 400 


Asp Gly Asn Phe Lys Val Gly Val His Ile Ala Asp Val Ser Tyr Phe 
                405                 410                 415     


Val Pro Glu Gly Ser Asp Leu Asp Lys Val Ala Ala Glu Arg Ala Thr 
            420                 425                 430         


Ser Val Tyr Leu Val Gln Lys Val Val Pro Met Leu Pro Arg Leu Leu 
        435                 440                 445             


Cys Glu Glu Leu Cys Ser Leu Asn Pro Met Ser Asp Lys Leu Thr Phe 
    450                 455                 460                 


Ser Val Ile Trp Thr Leu Thr Pro Glu Gly Lys Ile Leu Asp Glu Trp 
465                 470                 475                 480 


Phe Gly Arg Thr Ile Ile Arg Ser Cys Thr Lys Leu Ser Tyr Glu His 
                485                 490                 495     


Ala Gln Ser Met Ile Glu Ser Pro Thr Glu Lys Ile Pro Ala Lys Glu 
            500                 505                 510         


Leu Pro Pro Ile Ser Pro Glu His Ser Ser Glu Glu Val His Gln Gln 
        515                 520                 525             


Asn Ala Asp Lys Asp Gly Ala Ala His Leu Gln Ala Ser His Ser Pro 
    530                 535                 540                 


Ser Ala Glu Asp Ala Glu Ala Gln Pro Ser Thr Glu Glu Arg Leu Pro 
545                 550                 555                 560 


Glu Thr Arg Gly Ile Cys Asp Arg Asp Pro Asp Thr Arg Leu Phe Phe 
                565                 570                 575     


Leu Gln Gln Gln Ser Arg Val Leu Glu Ala Lys Pro Gln Asn Thr Ile 
            580                 585                 590         


Arg Val Glu Glu Gln Thr Thr Gln Leu Gln Ile 
        595                 600             


<210>  3082
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIS3L__Homo_sapiens__NP_001137160

<400>  3082

Met Leu Gln Lys Arg Glu Lys Val Leu Leu Leu Arg Thr Phe Gln Gly 
1               5                   10                  15      


Arg Thr Leu Arg Ile Val Arg Glu His Tyr Leu Arg Pro Cys Val Pro 
            20                  25                  30          


Cys His Ser Pro Leu Cys Pro Gln Pro Ala Ala Cys Ser His Asp Gly 
        35                  40                  45              


Lys Leu Leu Ser Ser Asp Val Thr His Tyr Val Ile Pro Asp Trp Lys 
    50                  55                  60                  


Val Val Gln Asp Tyr Leu Glu Ile Leu Glu Phe Pro Glu Leu Lys Gly 
65                  70                  75                  80  


Ile Ile Phe Met Gln Thr Ala Cys Gln Ala Val Gln His Gln Arg Gly 
                85                  90                  95      


Arg Arg Gln Tyr Asn Lys Leu Arg Asn Leu Leu Lys Asp Ala Arg His 
            100                 105                 110         


Asp Cys Ile Leu Phe Ala Asn Glu Phe Gln Gln Cys Cys Tyr Leu Pro 
        115                 120                 125             


Arg Glu Arg Gly Glu Ser Met Glu Lys Trp Gln Thr Arg Ser Ile Tyr 
    130                 135                 140                 


Asn Ala Ala Val Trp Tyr Tyr His His Cys Gln Asp Arg Met Pro Ile 
145                 150                 155                 160 


Val Met Val Thr Glu Asp Glu Glu Ala Ile Gln Gln Tyr Gly Ser Glu 
                165                 170                 175     


Thr Glu Gly Val Phe Val Ile Thr Phe Lys Asn Tyr Leu Asp Asn Phe 
            180                 185                 190         


Trp Pro Asp Leu Lys Ala Ala His Glu Leu Cys Asp Ser Ile Leu Gln 
        195                 200                 205             


Ser Arg Arg Glu Arg Glu Asn Glu Ser Gln Glu Ser His Gly Lys Glu 
    210                 215                 220                 


Tyr Pro Glu His Leu Pro Leu Glu Val Leu Glu Ala Gly Ile Lys Ser 
225                 230                 235                 240 


Gly Arg Tyr Ile Gln Gly Ile Leu Asn Val Asn Lys His Arg Ala Gln 
                245                 250                 255     


Ile Glu Ala Phe Val Arg Leu Gln Gly Ala Ser Ser Lys Asp Ser Asp 
            260                 265                 270         


Leu Val Ser Asp Ile Leu Ile His Gly Met Lys Ala Arg Asn Arg Ser 
        275                 280                 285             


Ile His Gly Asp Val Val Val Val Glu Leu Leu Pro Lys Asn Glu Trp 
    290                 295                 300                 


Lys Gly Arg Thr Val Ala Leu Cys Glu Asn Asp Cys Asp Asp Lys Ala 
305                 310                 315                 320 


Ser Gly Glu Ser Pro Ser Glu Pro Met Pro Thr Gly Arg Val Val Gly 
                325                 330                 335     


Ile Leu Gln Lys Asn Trp Arg Asp Tyr Val Val Thr Phe Pro Ser Lys 
            340                 345                 350         


Glu Glu Val Gln Ser Gln Gly Lys Asn Ala Gln Lys Ile Leu Val Thr 
        355                 360                 365             


Pro Trp Asp Tyr Arg Ile Pro Lys Ile Arg Ile Ser Thr Gln Gln Ala 
    370                 375                 380                 


Glu Thr Leu Gln Asp Phe Arg Val Val Val Arg Ile Asp Ser Trp Glu 
385                 390                 395                 400 


Ser Thr Ser Val Tyr Pro Asn Gly His Phe Val Arg Val Leu Gly Arg 
                405                 410                 415     


Ile Gly Asp Leu Glu Gly Glu Ile Ala Thr Ile Leu Val Glu Asn Ser 
            420                 425                 430         


Ile Ser Val Ile Pro Phe Ser Glu Ala Gln Met Cys Glu Met Pro Val 
        435                 440                 445             


Asn Thr Pro Glu Ser Pro Trp Lys Val Ser Pro Glu Glu Glu Gln Lys 
    450                 455                 460                 


Arg Lys Asp Leu Arg Lys Ser His Leu Val Phe Ser Ile Asp Pro Lys 
465                 470                 475                 480 


Gly Cys Glu Asp Val Asp Asp Thr Leu Ser Val Arg Thr Leu Asn Asn 
                485                 490                 495     


Gly Asn Leu Glu Leu Gly Val His Ile Ala Asp Val Thr His Phe Val 
            500                 505                 510         


Ala Pro Asn Ser Tyr Ile Asp Ile Glu Ala Arg Thr Arg Ala Thr Thr 
        515                 520                 525             


Tyr Tyr Leu Ala Asp Arg Arg Tyr Asp Met Leu Pro Ser Val Leu Ser 
    530                 535                 540                 


Ala Asp Leu Cys Ser Leu Leu Gly Gly Val Asp Arg Tyr Ala Val Ser 
545                 550                 555                 560 


Ile Met Trp Glu Leu Asp Lys Ala Ser Tyr Glu Ile Lys Lys Val Trp 
                565                 570                 575     


Tyr Gly Arg Thr Ile Ile Arg Ser Ala Tyr Lys Leu Phe Tyr Glu Ala 
            580                 585                 590         


Ala Gln Glu Leu Leu Asp Gly Asn Leu Ser Val Val Asp Asp Ile Pro 
        595                 600                 605             


Glu Phe Lys Asp Leu Asp Glu Lys Ser Arg Gln Ala Lys Leu Glu Glu 
    610                 615                 620                 


Leu Val Trp Ala Ile Gly Lys Leu Thr Asp Ile Ala Arg His Val Arg 
625                 630                 635                 640 


Ala Lys Arg Asp Gly Cys Gly Ala Leu Glu Leu Glu Gly Val Glu Val 
                645                 650                 655     


Cys Val Gln Leu Asp Asp Lys Lys Asn Ile His Asp Leu Ile Pro Lys 
            660                 665                 670         


Gln Pro Leu Glu Val His Glu Thr Val Ala Glu Cys Met Ile Leu Ala 
        675                 680                 685             


Asn His Trp Val Ala Lys Lys Ile Trp Glu Ser Phe Pro His Gln Ala 
    690                 695                 700                 


Leu Leu Arg Gln His Pro Pro Pro His Gln Glu Phe Phe Ser Glu Leu 
705                 710                 715                 720 


Arg Glu Cys Ala Lys Ala Lys Gly Phe Phe Ile Asp Thr Arg Ser Asn 
                725                 730                 735     


Lys Thr Leu Ala Asp Ser Leu Asp Asn Ala Asn Asp Pro His Asp Pro 
            740                 745                 750         


Ile Val Asn Arg Leu Leu Arg Ser Met Ala Thr Gln Ala Met Ser Asn 
        755                 760                 765             


Ala Leu Tyr Phe Ser Thr Gly Ser Cys Ala Glu Glu Glu Phe His His 
    770                 775                 780                 


Tyr Gly Leu Ala Leu Asp Lys Tyr Thr His Phe Thr Ser Pro Ile Arg 
785                 790                 795                 800 


Arg Tyr Ser Asp Ile Val Val His Arg Leu Leu Met Ala Ala Ile Ser 
                805                 810                 815     


Lys Asp Lys Lys Met Glu Ile Lys Gly Asn Leu Phe Ser Asn Lys Asp 
            820                 825                 830         


Leu Glu Glu Leu Cys Arg His Ile Asn Asn Arg Asn Gln Ala Ala Gln 
        835                 840                 845             


His Ser Gln Lys Gln Ser Thr Glu Leu Phe Gln Cys Met Tyr Phe Lys 
    850                 855                 860                 


Asp Lys Asp Pro Ala Thr Glu Glu Arg Cys Ile Ser Asp Gly Val Ile 
865                 870                 875                 880 


Tyr Ser Ile Arg Thr Asn Gly Val Leu Leu Phe Ile Pro Arg Phe Gly 
                885                 890                 895     


Ile Lys Gly Ala Ala Tyr Leu Lys Asn Lys Asp Gly Leu Val Ile Ser 
            900                 905                 910         


Cys Gly Pro Asp Ser Cys Ser Glu Trp Lys Pro Gly Ser Leu Gln Arg 
        915                 920                 925             


Phe Gln Asn Lys Ile Thr Ser Thr Thr Thr Asp Gly Glu Ser Val Thr 
    930                 935                 940                 


Phe His Leu Phe Asp His Val Thr Val Arg Ile Ser Ile Gln Ala Ser 
945                 950                 955                 960 


Arg Cys His Ser Asp Thr Ile Arg Leu Glu Ile Ile Ser Asn Lys Pro 
                965                 970                 975     


Tyr Lys Ile Pro Asn Thr Glu Leu Ile His Gln Ser Ser Pro Leu Leu 
            980                 985                 990         


Lys Ser Glu Leu Val Lys Glu Val  Thr Lys Ser Val Glu  Glu Ala Gln 
        995                 1000                 1005             


Leu Ala  Gln Glu Val Lys Val  Asn Ile Ile Gln Glu  Glu Tyr Gln 
    1010                 1015                 1020             


Glu Tyr  Arg Gln Thr Lys Gly  Arg Ser Leu Tyr Thr  Leu Leu Glu 
    1025                 1030                 1035             


Glu Ile  Arg Asp Leu Ala Leu  Leu Asp Val Ser Asn  Asn Tyr Gly 
    1040                 1045                 1050             


Ile 
    


<210>  3083
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DISC1__Homo_sapiens__NP_001012975

<400>  3083

Met Pro Gly Gly Gly Pro Gln Gly Ala Pro Ala Ala Ala Gly Gly Gly 
1               5                   10                  15      


Gly Val Ser His Arg Ala Gly Ser Arg Asp Cys Leu Pro Pro Ala Ala 
            20                  25                  30          


Cys Phe Arg Arg Arg Arg Leu Ala Arg Arg Pro Gly Tyr Met Arg Ser 
        35                  40                  45              


Ser Thr Gly Pro Gly Ile Gly Phe Leu Ser Pro Ala Val Gly Thr Leu 
    50                  55                  60                  


Phe Arg Phe Pro Gly Gly Val Ser Gly Glu Glu Ser His His Ser Glu 
65                  70                  75                  80  


Ser Arg Ala Arg Gln Cys Gly Leu Asp Ser Arg Gly Leu Leu Val Arg 
                85                  90                  95      


Ser Pro Val Ser Lys Ser Ala Ala Ala Pro Thr Val Thr Ser Val Arg 
            100                 105                 110         


Gly Thr Ser Ala His Phe Gly Ile Gln Leu Arg Gly Gly Thr Arg Leu 
        115                 120                 125             


Pro Asp Arg Leu Ser Trp Pro Cys Gly Pro Gly Ser Ala Gly Trp Gln 
    130                 135                 140                 


Gln Glu Phe Ala Ala Met Asp Ser Ser Glu Thr Leu Asp Ala Ser Trp 
145                 150                 155                 160 


Glu Ala Ala Cys Ser Asp Gly Ala Arg Arg Val Arg Ala Ala Gly Ser 
                165                 170                 175     


Leu Pro Ser Ala Glu Leu Ser Ser Asn Ser Cys Ser Pro Gly Cys Gly 
            180                 185                 190         


Pro Glu Val Pro Pro Thr Pro Pro Gly Ser His Ser Ala Phe Thr Ser 
        195                 200                 205             


Ser Phe Ser Phe Ile Arg Leu Ser Leu Gly Ser Ala Gly Glu Arg Gly 
    210                 215                 220                 


Glu Ala Glu Gly Cys Pro Pro Ser Arg Glu Ala Glu Ser His Cys Gln 
225                 230                 235                 240 


Ser Pro Gln Glu Met Gly Ala Lys Ala Ala Ser Leu Asp Gly Pro His 
                245                 250                 255     


Glu Asp Pro Arg Cys Leu Ser Arg Pro Phe Ser Leu Leu Ala Thr Arg 
            260                 265                 270         


Val Ser Ala Asp Leu Ala Gln Ala Ala Arg Asn Ser Ser Arg Pro Glu 
        275                 280                 285             


Arg Asp Met His Ser Leu Pro Asp Met Asp Pro Gly Ser Ser Ser Ser 
    290                 295                 300                 


Leu Asp Pro Ser Leu Ala Gly Cys Gly Gly Asp Gly Ser Ser Gly Ser 
305                 310                 315                 320 


Gly Asp Ala His Ser Trp Asp Thr Leu Leu Arg Lys Trp Glu Pro Val 
                325                 330                 335     


Leu Arg Asp Cys Leu Leu Arg Asn Arg Arg Gln Met Glu Val Ile Ser 
            340                 345                 350         


Leu Arg Leu Lys Leu Gln Lys Leu Gln Glu Asp Ala Val Glu Asn Asp 
        355                 360                 365             


Asp Tyr Asp Lys Ala Glu Thr Leu Gln Gln Arg Leu Glu Asp Leu Glu 
    370                 375                 380                 


Gln Glu Lys Ile Ser Leu His Phe Gln Leu Pro Ser Arg Gln Pro Ala 
385                 390                 395                 400 


Leu Ser Ser Phe Leu Gly His Leu Ala Ala Gln Val Gln Ala Ala Leu 
                405                 410                 415     


Arg Arg Gly Ala Thr Gln Gln Ala Ser Gly Asp Asp Thr His Thr Pro 
            420                 425                 430         


Leu Arg Met Glu Pro Arg Leu Leu Glu Pro Thr Ala Gln Asp Ser Leu 
        435                 440                 445             


His Val Ser Ile Thr Arg Arg Asp Trp Leu Leu Gln Glu Lys Gln Gln 
    450                 455                 460                 


Leu Gln Lys Glu Ile Glu Ala Leu Gln Ala Arg Met Phe Val Leu Glu 
465                 470                 475                 480 


Ala Lys Asp Gln Gln Leu Arg Arg Glu Ile Glu Glu Gln Glu Gln Gln 
                485                 490                 495     


Leu Gln Trp Gln Gly Cys Asp Leu Thr Pro Leu Val Gly Gln Leu Ser 
            500                 505                 510         


Leu Gly Gln Leu Gln Glu Val Ser Lys Ala Leu Gln Asp Thr Leu Ala 
        515                 520                 525             


Ser Ala Gly Gln Ile Pro Phe His Ala Glu Pro Pro Glu Thr Ile Arg 
    530                 535                 540                 


Ser Leu Gln Glu Arg Ile Lys Ser Leu Asn Leu Ser Leu Lys Glu Ile 
545                 550                 555                 560 


Thr Thr Lys Val Cys Met Ser Glu Lys Phe Cys Ser Thr Leu Arg Lys 
                565                 570                 575     


Lys Val Asn Asp Ile Glu Thr Gln Leu Pro Ala Leu Leu Glu Ala Lys 
            580                 585                 590         


Met His Ala Ile Ser Gly Asn His Phe Trp Thr Ala Lys Asp Leu Thr 
        595                 600                 605             


Glu Glu Ile Arg Ser Leu Thr Ser Glu Arg Glu Gly Leu Glu Gly Leu 
    610                 615                 620                 


Leu Ser Lys Leu Leu Val Leu Ser Ser Arg Asn Val Lys Lys Leu Gly 
625                 630                 635                 640 


Ser Val Lys Glu Asp Tyr Asn Arg Leu Arg Arg Glu Val Glu His Gln 
                645                 650                 655     


Glu Thr Ala Tyr Glu Thr Ser Val Lys Glu Asn Thr Met Lys Tyr Met 
            660                 665                 670         


Glu Thr Leu Lys Asn Lys Leu Cys Ser Cys Lys Cys Pro Leu Leu Gly 
        675                 680                 685             


Lys Val Trp Glu Ala Asp Leu Glu Ala Cys Arg Leu Leu Ile Gln Ser 
    690                 695                 700                 


Leu Gln Leu Gln Glu Ala Arg Gly Ser Leu Ser Val Glu Asp Glu Arg 
705                 710                 715                 720 


Gln Met Asp Asp Leu Glu Gly Ala Ala Pro Pro Ile Pro Pro Arg Leu 
                725                 730                 735     


His Ser Glu Asp Lys Arg Lys Thr Pro Leu Lys Glu Ser Tyr Ile Leu 
            740                 745                 750         


Ser Ala Glu Leu Gly Glu Lys Cys Glu Asp Ile Gly Lys Lys Leu Leu 
        755                 760                 765             


Tyr Leu Glu Asp Gln Leu His Thr Ala Ile His Ser His Asp Glu Asp 
    770                 775                 780                 


Leu Ile Gln Ser Leu Arg Arg Glu Leu Gln Met Val Lys Glu Thr Leu 
785                 790                 795                 800 


Gln Ala Met Ile Leu Gln Leu Gln Pro Ala Lys Glu Ala Gly Glu Arg 
                805                 810                 815     


Glu Ala Ala Ala Ser Cys Met Thr Ala Gly Val His Glu Ala Gln Ala 
            820                 825                 830         


<210>  3084
<211>  1524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DISP1__Homo_sapiens__NP_116279

<400>  3084

Met Ala Met Ser Asn Gly Asn Asn Asp Phe Val Val Leu Ser Asn Ser 
1               5                   10                  15      


Ser Ile Ala Thr Ser Ala Ala Asn Pro Ser Pro Leu Thr Pro Cys Asp 
            20                  25                  30          


Gly Asp His Ala Ala Gln Gln Leu Thr Pro Lys Glu Ala Thr Arg Thr 
        35                  40                  45              


Lys Val Ser Pro Asn Gly Cys Leu Gln Leu Asn Gly Thr Val Lys Ser 
    50                  55                  60                  


Ser Phe Leu Pro Leu Asp Asn Gln Arg Met Pro Gln Met Leu Pro Gln 
65                  70                  75                  80  


Cys Cys His Pro Cys Pro Tyr His His Pro Leu Thr Ser His Ser Ser 
                85                  90                  95      


His Gln Glu Cys His Pro Glu Ala Gly Pro Ala Ala Pro Ser Ala Leu 
            100                 105                 110         


Ala Ser Cys Cys Met Gln Pro His Ser Glu Tyr Ser Ala Ser Leu Cys 
        115                 120                 125             


Pro Asn His Ser Pro Val Tyr Gln Thr Thr Cys Cys Leu Gln Pro Ser 
    130                 135                 140                 


Pro Ser Phe Cys Leu His His Pro Trp Pro Asp His Phe Gln His Gln 
145                 150                 155                 160 


Pro Val Gln Gln His Ile Ala Asn Ile Arg Pro Ser Arg Pro Phe Lys 
                165                 170                 175     


Leu Pro Lys Ser Tyr Ala Ala Leu Ile Ala Asp Trp Pro Val Val Val 
            180                 185                 190         


Leu Gly Met Cys Thr Met Phe Ile Val Val Cys Ala Leu Val Gly Val 
        195                 200                 205             


Leu Val Pro Glu Leu Pro Asp Phe Ser Asp Pro Leu Leu Gly Phe Glu 
    210                 215                 220                 


Pro Arg Gly Thr Ala Ile Gly Gln Arg Leu Val Thr Trp Asn Asn Met 
225                 230                 235                 240 


Val Lys Asn Thr Gly Tyr Lys Ala Thr Leu Ala Asn Tyr Pro Phe Lys 
                245                 250                 255     


Tyr Ala Asp Glu Gln Ala Lys Ser His Arg Asp Asp Arg Trp Ser Asp 
            260                 265                 270         


Asp His Tyr Glu Arg Glu Lys Arg Glu Val Asp Trp Asn Phe His Lys 
        275                 280                 285             


Asp Ser Phe Phe Cys Asp Val Pro Ser Asp Arg Tyr Ser Arg Val Val 
    290                 295                 300                 


Phe Thr Ser Ser Gly Gly Glu Thr Leu Trp Asn Leu Pro Ala Ile Lys 
305                 310                 315                 320 


Ser Met Cys Asn Val Asp Asn Ser Arg Ile Arg Ser His Pro Gln Phe 
                325                 330                 335     


Gly Asp Leu Cys Gln Arg Thr Thr Ala Ala Ser Cys Cys Pro Ser Trp 
            340                 345                 350         


Thr Leu Gly Asn Tyr Ile Ala Ile Leu Asn Asn Arg Ser Ser Cys Gln 
        355                 360                 365             


Lys Ile Val Glu Arg Asp Val Ser His Thr Leu Lys Leu Leu Arg Thr 
    370                 375                 380                 


Cys Ala Lys His Tyr Gln Asn Gly Thr Leu Gly Pro Asp Cys Trp Asp 
385                 390                 395                 400 


Met Ala Ala Arg Arg Lys Asp Gln Leu Lys Cys Thr Asn Val Pro Arg 
                405                 410                 415     


Lys Cys Thr Lys Tyr Asn Ala Val Tyr Gln Ile Leu His Tyr Leu Val 
            420                 425                 430         


Asp Lys Asp Phe Met Thr Pro Lys Thr Ala Asp Tyr Ala Thr Pro Ala 
        435                 440                 445             


Leu Lys Tyr Ser Met Leu Phe Ser Pro Thr Glu Lys Gly Glu Ser Met 
    450                 455                 460                 


Met Asn Ile Tyr Leu Asp Asn Phe Glu Asn Trp Asn Ser Ser Asp Gly 
465                 470                 475                 480 


Val Thr Thr Ile Thr Gly Ile Glu Phe Gly Ile Lys His Ser Leu Phe 
                485                 490                 495     


Gln Asp Tyr Leu Leu Met Asp Thr Val Tyr Pro Ala Ile Ala Ile Val 
            500                 505                 510         


Ile Val Leu Leu Val Met Cys Val Tyr Thr Lys Ser Met Phe Ile Thr 
        515                 520                 525             


Leu Met Thr Met Phe Ala Ile Ile Ser Ser Leu Ile Val Ser Tyr Phe 
    530                 535                 540                 


Leu Tyr Arg Val Val Phe His Phe Glu Phe Phe Pro Phe Met Asn Leu 
545                 550                 555                 560 


Thr Ala Leu Ile Ile Leu Val Gly Ile Gly Ala Asp Asp Ala Phe Val 
                565                 570                 575     


Leu Cys Asp Val Trp Asn Tyr Thr Lys Phe Asp Lys Pro His Ala Glu 
            580                 585                 590         


Thr Ser Glu Thr Val Ser Ile Thr Leu Gln His Ala Ala Leu Ser Met 
        595                 600                 605             


Phe Val Thr Ser Phe Thr Thr Ala Ala Ala Phe Tyr Ala Asn Tyr Val 
    610                 615                 620                 


Ser Asn Ile Thr Ala Ile Arg Cys Phe Gly Val Tyr Ala Gly Thr Ala 
625                 630                 635                 640 


Ile Leu Val Asn Tyr Val Leu Met Val Thr Trp Leu Pro Ala Val Val 
                645                 650                 655     


Val Leu His Glu Arg Tyr Leu Leu Asn Ile Phe Thr Cys Phe Lys Lys 
            660                 665                 670         


Pro Gln Gln Gln Ile Tyr Asp Asn Lys Ser Cys Trp Thr Val Ala Cys 
        675                 680                 685             


Gln Lys Cys His Lys Val Leu Phe Ala Ile Ser Glu Ala Ser Arg Ile 
    690                 695                 700                 


Phe Phe Glu Lys Val Leu Pro Cys Ile Val Ile Lys Phe Arg Tyr Leu 
705                 710                 715                 720 


Trp Leu Phe Trp Phe Leu Ala Leu Thr Val Gly Gly Ala Tyr Ile Val 
                725                 730                 735     


Cys Ile Asn Pro Lys Met Lys Leu Pro Ser Leu Glu Leu Ser Glu Phe 
            740                 745                 750         


Gln Val Phe Arg Ser Ser His Pro Phe Glu Arg Tyr Asp Ala Glu Tyr 
        755                 760                 765             


Lys Lys Leu Phe Met Phe Glu Arg Val His His Gly Glu Glu Leu His 
    770                 775                 780                 


Met Pro Ile Thr Val Ile Trp Gly Val Ser Pro Glu Asp Asn Gly Asn 
785                 790                 795                 800 


Pro Leu Asn Pro Lys Ser Lys Gly Lys Leu Thr Leu Asp Ser Ser Phe 
                805                 810                 815     


Asn Ile Ala Ser Pro Ala Ser Gln Ala Trp Ile Leu His Phe Cys Gln 
            820                 825                 830         


Lys Leu Arg Asn Gln Thr Phe Phe Tyr Gln Thr Asp Glu Gln Asp Phe 
        835                 840                 845             


Thr Ser Cys Phe Ile Glu Thr Phe Lys Gln Trp Met Glu Asn Gln Asp 
    850                 855                 860                 


Cys Asp Glu Pro Ala Leu Tyr Pro Cys Cys Ser His Trp Ser Phe Pro 
865                 870                 875                 880 


Tyr Lys Gln Glu Ile Phe Glu Leu Cys Ile Lys Arg Ala Ile Met Glu 
                885                 890                 895     


Leu Glu Arg Ser Thr Gly Tyr His Leu Asp Ser Lys Thr Pro Gly Pro 
            900                 905                 910         


Arg Phe Asp Ile Asn Asp Thr Ile Arg Ala Val Val Leu Glu Phe Gln 
        915                 920                 925             


Ser Thr Tyr Leu Phe Thr Leu Ala Tyr Glu Lys Met His Gln Phe Tyr 
    930                 935                 940                 


Lys Glu Val Asp Ser Trp Ile Ser Ser Glu Leu Ser Ser Ala Pro Glu 
945                 950                 955                 960 


Gly Leu Ser Asn Gly Trp Phe Val Ser Asn Leu Glu Phe Tyr Asp Leu 
                965                 970                 975     


Gln Asp Ser Leu Ser Asp Gly Thr Leu Ile Ala Met Gly Leu Ser Val 
            980                 985                 990         


Ala Val Ala Phe Ser Val Met Leu  Leu Thr Thr Trp Asn  Ile Ile Ile 
        995                 1000                 1005             


Ser Leu  Tyr Ala Ile Ile Ser  Ile Ala Gly Thr Ile  Phe Val Thr 
    1010                 1015                 1020             


Val Gly  Ser Leu Val Leu Leu  Gly Trp Glu Leu Asn  Val Leu Glu 
    1025                 1030                 1035             


Ser Val  Thr Ile Ser Val Ala  Val Gly Leu Ser Val  Asp Phe Ala 
    1040                 1045                 1050             


Val His  Tyr Gly Val Ala Tyr  Arg Leu Ala Pro Asp  Pro Asp Arg 
    1055                 1060                 1065             


Glu Gly  Lys Val Ile Phe Ser  Leu Ser Arg Val Gly  Ser Ala Met 
    1070                 1075                 1080             


Ala Met  Ala Ala Leu Thr Thr  Phe Val Ala Gly Ala  Met Met Met 
    1085                 1090                 1095             


Pro Ser  Thr Val Leu Ala Tyr  Thr Gln Leu Gly Thr  Phe Met Met 
    1100                 1105                 1110             


Leu Ile  Met Cys Ile Ser Trp  Ala Phe Ala Thr Phe  Phe Phe Gln 
    1115                 1120                 1125             


Cys Met  Cys Arg Cys Leu Gly  Pro Gln Gly Thr Cys  Gly Gln Ile 
    1130                 1135                 1140             


Pro Leu  Pro Lys Lys Leu Gln  Cys Ser Ala Phe Ser  His Ala Leu 
    1145                 1150                 1155             


Ser Thr  Ser Pro Ser Asp Lys  Gly Gln Ser Lys Thr  His Thr Ile 
    1160                 1165                 1170             


Asn Ala  Tyr His Leu Asp Pro  Arg Gly Pro Lys Ser  Glu Leu Glu 
    1175                 1180                 1185             


His Glu  Phe Tyr Glu Leu Glu  Pro Leu Ala Ser His  Ser Cys Thr 
    1190                 1195                 1200             


Ala Pro  Glu Lys Thr Thr Tyr  Glu Glu Thr His Ile  Cys Ser Glu 
    1205                 1210                 1215             


Phe Phe  Asn Ser Gln Ala Lys  Asn Leu Gly Met Pro  Val His Ala 
    1220                 1225                 1230             


Ala Tyr  Asn Ser Glu Leu Ser  Lys Ser Thr Glu Ser  Asp Ala Gly 
    1235                 1240                 1245             


Ser Ala  Leu Leu Gln Pro Pro  Leu Glu Gln His Thr  Val Cys His 
    1250                 1255                 1260             


Phe Phe  Ser Leu Asn Gln Arg  Cys Ser Cys Pro Asp  Ala Tyr Lys 
    1265                 1270                 1275             


His Leu  Asn Tyr Gly Pro His  Ser Cys Gln Gln Met  Gly Asp Cys 
    1280                 1285                 1290             


Leu Cys  His Gln Cys Ser Pro  Thr Thr Ser Ser Phe  Val Gln Ile 
    1295                 1300                 1305             


Gln Asn  Gly Val Ala Pro Leu  Lys Ala Thr His Gln  Ala Val Glu 
    1310                 1315                 1320             


Gly Phe  Val His Pro Ile Thr  His Ile His His Cys  Pro Cys Leu 
    1325                 1330                 1335             


Gln Gly  Arg Val Lys Pro Ala  Gly Met Gln Asn Ser  Leu Pro Arg 
    1340                 1345                 1350             


Asn Phe  Phe Leu His Pro Val  Gln His Ile Gln Ala  Gln Glu Lys 
    1355                 1360                 1365             


Ile Gly  Lys Thr Asn Val His  Ser Leu Gln Arg Ser  Ile Glu Glu 
    1370                 1375                 1380             


His Leu  Pro Lys Met Ala Glu  Pro Ser Ser Phe Val  Cys Arg Ser 
    1385                 1390                 1395             


Thr Gly  Ser Leu Leu Lys Thr  Cys Cys Asp Pro Glu  Asn Lys Gln 
    1400                 1405                 1410             


Arg Glu  Leu Cys Lys Asn Arg  Asp Val Ser Asn Leu  Glu Ser Ser 
    1415                 1420                 1425             


Gly Gly  Thr Glu Asn Lys Ala  Gly Gly Lys Val Glu  Leu Ser Leu 
    1430                 1435                 1440             


Ser Gln  Thr Asp Ala Ser Val  Asn Ser Glu His Phe  Asn Gln Asn 
    1445                 1450                 1455             


Glu Pro  Lys Val Leu Phe Asn  His Leu Met Gly Glu  Ala Gly Cys 
    1460                 1465                 1470             


Arg Ser  Cys Pro Asn Asn Ser  Gln Ser Cys Gly Arg  Ile Val Arg 
    1475                 1480                 1485             


Val Lys  Cys Asn Ser Val Asp  Cys Gln Met Pro Asn  Met Glu Ala 
    1490                 1495                 1500             


Asn Val  Pro Ala Val Leu Thr  His Ser Glu Leu Ser  Gly Glu Ser 
    1505                 1510                 1515             


Leu Leu  Ile Lys Thr Leu 
    1520                 


<210>  3085
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIXDC1__Homo_sapiens__NP_001033043

<400>  3085

Met Leu Ala Cys Leu Thr Arg Gly Asn Leu Leu Asp Val Leu Gln Glu 
1               5                   10                  15      


Gly Phe Asn Glu Gln Gln Leu Gln Ala Tyr Val Ala Trp Val Asn Ala 
            20                  25                  30          


Gln Leu Lys Lys Arg Pro Ala Val Lys Pro Val Gln Asp Leu Arg Gln 
        35                  40                  45              


Asp Leu Arg Asp Gly Val Ile Leu Ala Tyr Leu Ile Glu Ile Val Ala 
    50                  55                  60                  


Gly Glu Lys Leu Ser Gly Val Gln Leu Ser Pro Gly Asn Gln Gln Glu 
65                  70                  75                  80  


Met Lys Asn Asn Val Glu Lys Val Leu Gln Phe Val Ala Ser Lys Lys 
                85                  90                  95      


Ile Arg Met His Gln Thr Ser Ala Lys Asp Ile Val Asp Gly Asn Leu 
            100                 105                 110         


Lys Ser Ile Met Arg Leu Val Leu Ala Leu Ala Ala His Phe Lys Pro 
        115                 120                 125             


Gly Ser Ser Arg Thr Val Asn Gln Gly Arg Asp Ser Arg Ala Pro Leu 
    130                 135                 140                 


Gln Ser His Arg Pro His Cys Ala Thr Ala Val Ala Gln Gly Ala Ala 
145                 150                 155                 160 


Ala Ala Leu Ala Asp Val Cys His Asp Met Ser Arg Ser Gly Arg Asp 
                165                 170                 175     


Val Phe Arg Tyr Arg Gln Arg Asn Ser Ser Met Asp Glu Glu Ile Glu 
            180                 185                 190         


Asn Pro Tyr Trp Ser Val Arg Ala Leu Val Gln Gln Tyr Glu Gly Gln 
        195                 200                 205             


Gln Arg Ser Pro Ser Glu Ser Ser Cys Ser Ser Leu Thr Ser Pro Ser 
    210                 215                 220                 


Pro Ile His Ser Ala Lys Ser Glu Ser Ile Ile Thr Gln Ser Glu Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Val Ile Ile Pro Ala Glu Gly Ile Glu Asn Arg Thr 
                245                 250                 255     


Glu Gly Thr Asp Ser Pro Leu Ser Arg Asp Trp Arg Pro Gly Ser Pro 
            260                 265                 270         


Gly Thr Tyr Leu Glu Thr Ser Trp Glu Glu Gln Leu Leu Glu Gln Gln 
        275                 280                 285             


Glu Tyr Leu Glu Lys Glu Met Glu Glu Ala Lys Lys Met Ile Ser Gly 
    290                 295                 300                 


Leu Gln Ala Leu Leu Leu Asn Gly Ser Leu Pro Glu Asp Glu Gln Glu 
305                 310                 315                 320 


Arg Pro Leu Ala Leu Cys Glu Pro Gly Val Asn Pro Glu Glu Gln Leu 
                325                 330                 335     


Ile Ile Ile Gln Ser Arg Leu Asp Gln Ser Met Glu Glu Asn Gln Asp 
            340                 345                 350         


Leu Lys Lys Glu Leu Leu Lys Cys Lys Gln Glu Ala Arg Asn Leu Gln 
        355                 360                 365             


Gly Ile Lys Asp Ala Leu Gln Gln Arg Leu Thr Gln Gln Asp Thr Ser 
    370                 375                 380                 


Val Leu Gln Leu Lys Gln Glu Leu Leu Arg Ala Asn Met Asp Lys Asp 
385                 390                 395                 400 


Glu Leu His Asn Gln Asn Val Asp Leu Gln Arg Lys Leu Asp Glu Arg 
                405                 410                 415     


Asn Arg Leu Leu Gly Glu Tyr Lys Lys Glu Leu Gly Gln Lys Asp Arg 
            420                 425                 430         


Leu Leu Gln Gln His Gln Ala Lys Leu Glu Glu Ala Leu Arg Lys Leu 
        435                 440                 445             


Ser Asp Val Ser Tyr His Gln Val Asp Leu Glu Arg Glu Leu Glu His 
    450                 455                 460                 


Lys Asp Val Leu Leu Ala His Cys Met Lys Arg Glu Ala Asp Glu Ala 
465                 470                 475                 480 


Thr Asn Tyr Asn Ser His Asn Ser Gln Ser Asn Gly Phe Leu Leu Pro 
                485                 490                 495     


Thr Ala Gly Lys Gly Ala Thr Ser Val Ser Asn Arg Gly Thr Ser Asp 
            500                 505                 510         


Leu Gln Leu Val Arg Asp Ala Leu Arg Ser Leu Arg Asn Ser Phe Ser 
        515                 520                 525             


Gly His Asp Pro Gln His His Thr Ile Asp Ser Leu Glu Gln Gly Ile 
    530                 535                 540                 


Ser Ser Leu Met Glu Arg Leu His Val Met Glu Thr Gln Lys Lys Gln 
545                 550                 555                 560 


Glu Arg Lys Val Arg Val Lys Ser Pro Arg Thr Gln Val Gly Ser Glu 
                565                 570                 575     


Tyr Arg Glu Ser Trp Pro Pro Asn Ser Lys Leu Pro His Ser Gln Ser 
            580                 585                 590         


Ser Pro Thr Val Ser Ser Thr Cys Thr Lys Val Leu Tyr Phe Thr Asp 
        595                 600                 605             


Arg Ser Leu Thr Pro Phe Met Val Asn Ile Pro Lys Arg Leu Glu Glu 
    610                 615                 620                 


Val Thr Leu Lys Asp Phe Lys Ala Ala Ile Asp Arg Glu Gly Asn His 
625                 630                 635                 640 


Arg Tyr His Phe Lys Ala Leu Asp Pro Glu Phe Gly Thr Val Lys Glu 
                645                 650                 655     


Glu Ile Phe His Asp Asp Asp Ala Ile Pro Gly Trp Glu Gly Lys Ile 
            660                 665                 670         


Val Ala Trp Val Glu Glu Asp His Gly Glu Asn 
        675                 680             


<210>  3086
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DKC1__Homo_sapiens__NP_001354

<400>  3086

Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys 
1               5                   10                  15      


Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Glu Ile Gln His 
            20                  25                  30          


Ala Glu Glu Phe Leu Ile Lys Pro Glu Ser Lys Val Ala Lys Leu Asp 
        35                  40                  45              


Thr Ser Gln Trp Pro Leu Leu Leu Lys Asn Phe Asp Lys Leu Asn Val 
    50                  55                  60                  


Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn Pro Leu Lys 
65                  70                  75                  80  


Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn Leu Asp Lys 
                85                  90                  95      


Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile Arg Arg Ile 
            100                 105                 110         


Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp Pro Lys Val 
        115                 120                 125             


Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg Leu Val Lys 
    130                 135                 140                 


Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val Arg Leu His 
145                 150                 155                 160 


Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu Glu Thr Leu 
                165                 170                 175     


Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala Val Lys Arg 
            180                 185                 190         


Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile Glu Tyr Asp 
        195                 200                 205             


Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu Ala Gly Thr 
    210                 215                 220                 


Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu Gly Val Gly 
225                 230                 235                 240 


Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val Met Ser Glu 
                245                 250                 255     


Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala Gln Trp Leu 
            260                 265                 270         


Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val Val Tyr Pro 
        275                 280                 285             


Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met Lys Asp Ser 
    290                 295                 300                 


Ala Val Asn Ala Ile Cys Tyr Gly Ala Lys Ile Met Leu Pro Gly Val 
305                 310                 315                 320 


Leu Arg Tyr Glu Asp Gly Ile Glu Val Asn Gln Glu Ile Val Val Ile 
                325                 330                 335     


Thr Thr Lys Gly Glu Ala Ile Cys Met Ala Ile Ala Leu Met Thr Thr 
            340                 345                 350         


Ala Val Ile Ser Thr Cys Asp His Gly Ile Val Ala Lys Ile Lys Arg 
        355                 360                 365             


Val Ile Met Glu Arg Asp Thr Tyr Pro Arg Lys Trp Gly Leu Gly Pro 
    370                 375                 380                 


Lys Ala Ser Gln Lys Lys Leu Met Ile Lys Gln Gly Leu Leu Asp Lys 
385                 390                 395                 400 


His Gly Lys Pro Thr Asp Ser Thr Pro Ala Thr Trp Lys Gln Glu Tyr 
                405                 410                 415     


Val Asp Tyr Ser Glu Ser Ala Lys Lys Glu Val Val Ala Glu Val Val 
            420                 425                 430         


Lys Ala Pro Gln Val Val Ala Glu Ala Ala Lys Thr Ala Lys Arg Lys 
        435                 440                 445             


Arg Glu Ser Glu Ser Glu Ser Asp Glu Thr Pro Pro Ala Ala Pro Gln 
    450                 455                 460                 


Leu Ile Lys Lys Glu Lys Lys Lys Ser Lys Lys Asp Lys Lys Ala Lys 
465                 470                 475                 480 


Ala Gly Leu Glu Ser Gly Ala Glu Pro Gly Asp Gly Asp Ser Asp Thr 
                485                 490                 495     


Thr Lys Lys Lys Lys Lys Lys Lys Lys Ala Lys Glu Val Glu Leu Val 
            500                 505                 510         


Ser Glu 
        


<210>  3087
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DKK1__Homo_sapiens__NP_036374

<400>  3087

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265     


<210>  3088
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DKK2__Homo_sapiens__NP_055236

<400>  3088

Met Ala Ala Leu Met Arg Ser Lys Asp Ser Ser Cys Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Val Leu Met Val Glu Ser Ser Gln Ile Gly Ser Ser Arg 
            20                  25                  30          


Ala Lys Leu Asn Ser Ile Lys Ser Ser Leu Gly Gly Glu Thr Pro Gly 
        35                  40                  45              


Gln Ala Ala Asn Arg Ser Ala Gly Met Tyr Gln Gly Leu Ala Phe Gly 
    50                  55                  60                  


Gly Ser Lys Lys Gly Lys Asn Leu Gly Gln Ala Tyr Pro Cys Ser Ser 
65                  70                  75                  80  


Asp Lys Glu Cys Glu Val Gly Arg Tyr Cys His Ser Pro His Gln Gly 
                85                  90                  95      


Ser Ser Ala Cys Met Val Cys Arg Arg Lys Lys Lys Arg Cys His Arg 
            100                 105                 110         


Asp Gly Met Cys Cys Pro Ser Thr Arg Cys Asn Asn Gly Ile Cys Ile 
        115                 120                 125             


Pro Val Thr Glu Ser Ile Leu Thr Pro His Ile Pro Ala Leu Asp Gly 
    130                 135                 140                 


Thr Arg His Arg Asp Arg Asn His Gly His Tyr Ser Asn His Asp Leu 
145                 150                 155                 160 


Gly Trp Gln Asn Leu Gly Arg Pro His Thr Lys Met Ser His Ile Lys 
                165                 170                 175     


Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly 
            180                 185                 190         


Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu 
        195                 200                 205             


His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly 
    210                 215                 220                 


Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys 
225                 230                 235                 240 


Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys 
                245                 250                 255     


Gln Lys Ile 
            


<210>  3089
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DKK3__Homo_sapiens__XP_006718241

<400>  3089

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  3090
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DKK4__Homo_sapiens__XP_011542791

<400>  3090

Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu 
1               5                   10                  15      


Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu 
            20                  25                  30          


His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn 
        35                  40                  45              


Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala 
    50                  55                  60                  


Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys 
65                  70                  75                  80  


Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Met Glu Asp Ala 
                85                  90                  95      


Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala 
            100                 105                 110         


Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys 
        115                 120                 125             


Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Gln Glu Gly Glu Ser 
    130                 135                 140                 


Cys Leu Arg Thr Phe Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His 
145                 150                 155                 160 


Phe Trp Thr Lys Ile Cys Lys Pro Val Leu Leu Glu Gly Gln Val Cys 
                165                 170                 175     


Ser Arg Arg Gly His Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln 
            180                 185                 190         


Arg Cys Asp Cys Gly Pro Gly Leu Leu Cys Arg Ser Gln Leu Thr Ser 
        195                 200                 205             


Asn Arg Gln His Ala Arg Leu Arg Val Cys Gln Lys Ile Glu Lys Leu 
    210                 215                 220                 


<210>  3091
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DKKL1__Homo_sapiens__NP_001184230

<400>  3091

Met Gly Glu Ala Ser Pro Pro Ala Pro Ala Arg Arg His Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Thr Leu Val Ile Pro Ser Ala Ala Ala Pro 
            20                  25                  30          


Ile His Asp Ala Asp Ala Gln Glu Ser Ser Leu Gly Leu Thr Gly Leu 
        35                  40                  45              


Gln Ser Leu Leu Gln Gly Phe Ser Arg Leu Phe Leu Lys Gly Asn Leu 
    50                  55                  60                  


Leu Arg Gly Ile Asp Ser Leu Phe Ser Ala Pro Met Asp Phe Arg Gly 
65                  70                  75                  80  


Leu Pro Gly Asn Tyr His Lys Glu Glu Asn Gln Glu His Gln Leu Gly 
                85                  90                  95      


Asn Asn Thr Leu Ser Ser His Leu Gln Ile Asp Lys Val Pro Arg Met 
            100                 105                 110         


Glu Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala Thr Asp Ser Phe 
        115                 120                 125             


His Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile Ile Lys Leu Pro 
    130                 135                 140                 


Arg Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly His Trp Leu Ser 
145                 150                 155                 160 


Glu Lys Arg His Arg Leu Gln Ala Ile Arg Asp Gly Leu Arg Lys Gly 
                165                 170                 175     


Thr His Lys Asp Val Leu Glu Glu Gly Thr Glu Ser Ser Ser His Ser 
            180                 185                 190         


Arg Leu Ser Pro Arg Lys Thr His Leu Leu Tyr Ile Leu Arg Pro Ser 
        195                 200                 205             


Arg Gln Leu 
    210     


<210>  3092
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLAT__Homo_sapiens__NP_001922

<400>  3092

Met Trp Arg Val Cys Ala Arg Arg Ala Gln Asn Val Ala Pro Trp Ala 
1               5                   10                  15      


Gly Leu Glu Ala Arg Trp Thr Ala Leu Gln Glu Val Pro Gly Thr Pro 
            20                  25                  30          


Arg Val Thr Ser Arg Ser Gly Pro Ala Pro Ala Arg Arg Asn Ser Val 
        35                  40                  45              


Thr Thr Gly Tyr Gly Gly Val Arg Ala Leu Cys Gly Trp Thr Pro Ser 
    50                  55                  60                  


Ser Gly Ala Thr Pro Arg Asn Arg Leu Leu Leu Gln Leu Leu Gly Ser 
65                  70                  75                  80  


Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu 
                85                  90                  95      


Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu 
            100                 105                 110         


Lys Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val 
        115                 120                 125             


Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr 
    130                 135                 140                 


Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly 
145                 150                 155                 160 


Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe 
                165                 170                 175     


Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala 
            180                 185                 190         


Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala 
        195                 200                 205             


Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro 
    210                 215                 220                 


Ala Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys 
225                 230                 235                 240 


Lys Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu 
                245                 250                 255     


Thr Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu 
            260                 265                 270         


Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr 
        275                 280                 285             


Pro Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala 
    290                 295                 300                 


Asp Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Val Pro Pro 
305                 310                 315                 320 


Pro Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu 
                325                 330                 335     


Ala Pro Thr Pro Ser Ala Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys 
            340                 345                 350         


Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu Lys 
        355                 360                 365             


Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile 
    370                 375                 380                 


Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala 
385                 390                 395                 400 


Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro 
                405                 410                 415     


Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile 
            420                 425                 430         


Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu 
        435                 440                 445             


Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu 
    450                 455                 460                 


Asn Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile 
465                 470                 475                 480 


Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser 
                485                 490                 495     


Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser 
            500                 505                 510         


Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn 
        515                 520                 525             


Ala His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu 
    530                 535                 540                 


Ala Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly 
545                 550                 555                 560 


Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe 
                565                 570                 575     


Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala 
            580                 585                 590         


Ser Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Phe Asp Val 
        595                 600                 605             


Ala Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp 
    610                 615                 620                 


Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu 
625                 630                 635                 640 


Lys Pro Ile Thr Met Leu Leu 
                645         


<210>  3093
<211>  1091
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLC1__Homo_sapiens__NP_006085

<400>  3093

Met Cys Arg Lys Lys Pro Asp Thr Met Ile Leu Thr Gln Ile Glu Ala 
1               5                   10                  15      


Lys Glu Ala Cys Asp Trp Leu Arg Ala Thr Gly Phe Pro Gln Tyr Ala 
            20                  25                  30          


Gln Leu Tyr Glu Asp Phe Leu Phe Pro Ile Asp Ile Ser Leu Val Lys 
        35                  40                  45              


Arg Glu His Asp Phe Leu Asp Arg Asp Ala Ile Glu Ala Leu Cys Arg 
    50                  55                  60                  


Arg Leu Asn Thr Leu Asn Lys Cys Ala Val Met Lys Leu Glu Ile Ser 
65                  70                  75                  80  


Pro His Arg Lys Arg Ser Asp Asp Ser Asp Glu Asp Glu Pro Cys Ala 
                85                  90                  95      


Ile Ser Gly Lys Trp Thr Phe Gln Arg Asp Ser Lys Arg Trp Ser Arg 
            100                 105                 110         


Leu Glu Glu Phe Asp Val Phe Ser Pro Lys Gln Asp Leu Val Pro Gly 
        115                 120                 125             


Ser Pro Asp Asp Ser His Pro Lys Asp Gly Pro Ser Pro Gly Gly Thr 
    130                 135                 140                 


Leu Met Asp Leu Ser Glu Arg Gln Glu Val Ser Ser Val Arg Ser Leu 
145                 150                 155                 160 


Ser Ser Thr Gly Ser Leu Pro Ser His Ala Pro Pro Ser Glu Asp Ala 
                165                 170                 175     


Ala Thr Pro Arg Thr Asn Ser Val Ile Ser Val Cys Ser Ser Ser Asn 
            180                 185                 190         


Leu Ala Gly Asn Asp Asp Ser Phe Gly Ser Leu Pro Ser Pro Lys Glu 
        195                 200                 205             


Leu Ser Ser Phe Ser Phe Ser Met Lys Gly His Glu Lys Thr Ala Lys 
    210                 215                 220                 


Ser Lys Thr Arg Ser Leu Leu Lys Arg Met Glu Ser Leu Lys Leu Lys 
225                 230                 235                 240 


Ser Ser His His Ser Lys His Lys Ala Pro Ser Lys Leu Gly Leu Ile 
                245                 250                 255     


Ile Ser Gly Pro Ile Leu Gln Glu Gly Met Asp Glu Glu Lys Leu Lys 
            260                 265                 270         


Gln Leu Asn Cys Val Glu Ile Ser Ala Leu Asn Gly Asn Arg Ile Asn 
        275                 280                 285             


Val Pro Met Val Arg Lys Arg Ser Val Ser Asn Ser Thr Gln Thr Ser 
    290                 295                 300                 


Ser Ser Ser Ser Gln Ser Glu Thr Ser Ser Ala Val Ser Thr Pro Ser 
305                 310                 315                 320 


Pro Val Thr Arg Thr Arg Ser Leu Ser Ala Cys Asn Lys Arg Val Gly 
                325                 330                 335     


Met Tyr Leu Glu Gly Phe Asp Pro Phe Asn Gln Ser Thr Phe Asn Asn 
            340                 345                 350         


Val Val Glu Gln Asn Phe Lys Asn Arg Glu Ser Tyr Pro Glu Asp Thr 
        355                 360                 365             


Val Phe Tyr Ile Pro Glu Asp His Lys Pro Gly Thr Phe Pro Lys Ala 
    370                 375                 380                 


Leu Thr Asn Gly Ser Phe Ser Pro Ser Gly Asn Asn Gly Ser Val Asn 
385                 390                 395                 400 


Trp Arg Thr Gly Ser Phe His Gly Pro Gly His Ile Ser Leu Arg Arg 
                405                 410                 415     


Glu Asn Ser Ser Asp Ser Pro Lys Glu Leu Lys Arg Arg Asn Ser Ser 
            420                 425                 430         


Ser Ser Met Ser Ser Arg Leu Ser Ile Tyr Asp Asn Val Pro Gly Ser 
        435                 440                 445             


Ile Leu Tyr Ser Ser Ser Gly Asp Leu Ala Asp Leu Glu Asn Glu Asp 
    450                 455                 460                 


Ile Phe Pro Glu Leu Asp Asp Ile Leu Tyr His Val Lys Gly Met Gln 
465                 470                 475                 480 


Arg Ile Val Asn Gln Trp Ser Glu Lys Phe Ser Asp Glu Gly Asp Ser 
                485                 490                 495     


Asp Ser Ala Leu Asp Ser Val Ser Pro Cys Pro Ser Ser Pro Lys Gln 
            500                 505                 510         


Ile His Leu Asp Val Asp Asn Asp Arg Thr Thr Pro Ser Asp Leu Asp 
        515                 520                 525             


Ser Thr Gly Asn Ser Leu Asn Glu Pro Glu Glu Pro Ser Glu Ile Pro 
    530                 535                 540                 


Glu Arg Arg Asp Ser Gly Val Gly Ala Ser Leu Thr Arg Ser Asn Arg 
545                 550                 555                 560 


His Arg Leu Arg Trp His Ser Phe Gln Ser Ser His Arg Pro Ser Leu 
                565                 570                 575     


Asn Ser Val Ser Leu Gln Ile Asn Cys Gln Ser Val Ala Gln Met Asn 
            580                 585                 590         


Leu Leu Gln Lys Tyr Ser Leu Leu Lys Leu Thr Ala Leu Leu Glu Lys 
        595                 600                 605             


Tyr Thr Pro Ser Asn Lys His Gly Phe Ser Trp Ala Val Pro Lys Phe 
    610                 615                 620                 


Met Lys Arg Ile Lys Val Pro Asp Tyr Lys Asp Arg Ser Val Phe Gly 
625                 630                 635                 640 


Val Pro Leu Thr Val Asn Val Gln Arg Thr Gly Gln Pro Leu Pro Gln 
                645                 650                 655     


Ser Ile Gln Gln Ala Met Arg Tyr Leu Arg Asn His Cys Leu Asp Gln 
            660                 665                 670         


Val Gly Leu Phe Arg Lys Ser Gly Val Lys Ser Arg Ile Gln Ala Leu 
        675                 680                 685             


Arg Gln Met Asn Glu Gly Ala Ile Asp Cys Val Asn Tyr Glu Gly Gln 
    690                 695                 700                 


Ser Ala Tyr Asp Val Ala Asp Met Leu Lys Gln Tyr Phe Arg Asp Leu 
705                 710                 715                 720 


Pro Glu Pro Leu Met Thr Asn Lys Leu Ser Glu Thr Phe Leu Gln Ile 
                725                 730                 735     


Tyr Gln Tyr Val Pro Lys Asp Gln Arg Leu Gln Ala Ile Lys Ala Ala 
            740                 745                 750         


Ile Met Leu Leu Pro Asp Glu Asn Arg Glu Val Leu Gln Thr Leu Leu 
        755                 760                 765             


Tyr Phe Leu Ser Asp Val Thr Ala Ala Val Lys Glu Asn Gln Met Thr 
    770                 775                 780                 


Pro Thr Asn Leu Ala Val Cys Leu Ala Pro Ser Leu Phe His Leu Asn 
785                 790                 795                 800 


Thr Leu Lys Arg Glu Asn Ser Ser Pro Arg Val Met Gln Arg Lys Gln 
                805                 810                 815     


Ser Leu Gly Lys Pro Asp Gln Lys Asp Leu Asn Glu Asn Leu Ala Ala 
            820                 825                 830         


Thr Gln Gly Leu Ala His Met Ile Ala Glu Cys Lys Lys Leu Phe Gln 
        835                 840                 845             


Val Pro Glu Glu Met Ser Arg Cys Arg Asn Ser Tyr Thr Glu Gln Glu 
    850                 855                 860                 


Leu Lys Pro Leu Thr Leu Glu Ala Leu Gly His Leu Gly Asn Asp Asp 
865                 870                 875                 880 


Ser Ala Asp Tyr Gln His Phe Leu Gln Asp Cys Val Asp Gly Leu Phe 
                885                 890                 895     


Lys Glu Val Lys Glu Lys Phe Lys Gly Trp Val Ser Tyr Ser Thr Ser 
            900                 905                 910         


Glu Gln Ala Glu Leu Ser Tyr Lys Lys Val Ser Glu Gly Pro Pro Leu 
        915                 920                 925             


Arg Leu Trp Arg Ser Val Ile Glu Val Pro Ala Val Pro Glu Glu Ile 
    930                 935                 940                 


Leu Lys Arg Leu Leu Lys Glu Gln His Leu Trp Asp Val Asp Leu Leu 
945                 950                 955                 960 


Asp Ser Lys Val Ile Glu Ile Leu Asp Ser Gln Thr Glu Ile Tyr Gln 
                965                 970                 975     


Tyr Val Gln Asn Ser Met Ala Pro His Pro Ala Arg Asp Tyr Val Val 
            980                 985                 990         


Leu Arg Thr Trp Arg Thr Asn Leu  Pro Lys Gly Ala Cys  Ala Leu Leu 
        995                 1000                 1005             


Leu Thr  Ser Val Asp His Asp  Arg Ala Pro Val Val  Gly Val Arg 
    1010                 1015                 1020             


Val Asn  Val Leu Leu Ser Arg  Tyr Leu Ile Glu Pro  Cys Gly Pro 
    1025                 1030                 1035             


Gly Lys  Ser Lys Leu Thr Tyr  Met Cys Arg Val Asp  Leu Arg Gly 
    1040                 1045                 1050             


His Met  Pro Glu Trp Tyr Thr  Lys Ser Phe Gly His  Leu Cys Ala 
    1055                 1060                 1065             


Ala Glu  Val Val Lys Ile Arg  Asp Ser Phe Ser Asn  Gln Asn Thr 
    1070                 1075                 1080             


Glu Thr  Lys Asp Thr Lys Ser  Arg 
    1085                 1090     


<210>  3094
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLD__Homo_sapiens__NP_000099

<400>  3094

Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His 
1               5                   10                  15      


Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu 
            20                  25                  30          


Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly 
        35                  40                  45              


Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly 
    50                  55                  60                  


Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys 
65                  70                  75                  80  


Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His 
                85                  90                  95      


Tyr Tyr His Met Ala His Gly Lys Asp Phe Ala Ser Arg Gly Ile Glu 
            100                 105                 110         


Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser 
        115                 120                 125             


Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln 
    130                 135                 140                 


Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn 
145                 150                 155                 160 


Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr 
                165                 170                 175     


Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly 
            180                 185                 190         


Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser 
        195                 200                 205             


Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile 
    210                 215                 220                 


Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr 
225                 230                 235                 240 


Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu 
                245                 250                 255     


Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe 
            260                 265                 270         


Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys 
        275                 280                 285             


Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile 
    290                 295                 300                 


Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys 
305                 310                 315                 320 


Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg 
                325                 330                 335     


Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala 
            340                 345                 350         


Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp 
        355                 360                 365             


Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile 
    370                 375                 380                 


Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala 
385                 390                 395                 400 


Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr 
                405                 410                 415     


Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn 
            420                 425                 430         


Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp 
        435                 440                 445             


Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val 
    450                 455                 460                 


Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile 
465                 470                 475                 480 


Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu 
                485                 490                 495     


Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe 
            500                 505                 


<210>  3095
<211>  1755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLEC1__Homo_sapiens__NP_031361

<400>  3095

Met Glu Thr Arg Ser Ser Lys Thr Arg Arg Ser Leu Ala Ser Arg Thr 
1               5                   10                  15      


Asn Glu Cys Gln Gly Thr Met Trp Ala Pro Thr Ser Pro Pro Ala Gly 
            20                  25                  30          


Ser Ser Ser Pro Ser Gln Pro Thr Trp Lys Ser Ser Leu Tyr Ser Ser 
        35                  40                  45              


Leu Ala Tyr Ser Glu Ala Phe His Tyr Ser Phe Ala Ala Arg Pro Arg 
    50                  55                  60                  


Arg Leu Thr Gln Leu Ala Leu Ala Gln Arg Pro Glu Pro Gln Leu Leu 
65                  70                  75                  80  


Arg Leu Arg Pro Ser Ser Leu Arg Thr Gln Asp Ile Ser His Leu Leu 
                85                  90                  95      


Thr Gly Val Phe Arg Asn Leu Tyr Ser Ala Glu Val Ile Gly Asp Glu 
            100                 105                 110         


Val Ser Ala Ser Leu Ile Lys Ala Arg Gly Ser Glu Asn Glu Arg His 
        115                 120                 125             


Glu Glu Phe Val Asp Gln Leu Gln Gln Ile Arg Glu Leu Tyr Lys Gln 
    130                 135                 140                 


Arg Leu Asp Glu Phe Glu Met Leu Glu Arg His Ile Thr Gln Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Ile Ala Glu Asn Glu Arg Val Met Ser Gln Ala Gly Val 
                165                 170                 175     


Gln Asp Leu Glu Ser Leu Val Arg Leu Pro Pro Val Lys Ser Val Ser 
            180                 185                 190         


Arg Trp Cys Ile Asp Ser Glu Leu Leu Arg Lys His His Leu Ile Ser 
        195                 200                 205             


Pro Glu Asp Tyr Tyr Thr Asp Thr Val Pro Phe His Ser Ala Pro Lys 
    210                 215                 220                 


Gly Ile Ser Leu Pro Gly Cys Ser Lys Leu Thr Phe Ser Cys Glu Lys 
225                 230                 235                 240 


Arg Ser Val Gln Lys Lys Glu Leu Asn Lys Lys Leu Glu Asp Ser Cys 
                245                 250                 255     


Arg Lys Lys Leu Ala Glu Phe Glu Asp Glu Leu Asp His Thr Val Asp 
            260                 265                 270         


Ser Leu Thr Trp Asn Leu Thr Pro Lys Ala Lys Glu Arg Thr Arg Glu 
        275                 280                 285             


Pro Leu Lys Lys Ala Ser Gln Pro Arg Asn Lys Asn Trp Met Asn His 
    290                 295                 300                 


Leu Arg Val Pro Gln Arg Glu Leu Asp Arg Leu Leu Leu Ala Arg Met 
305                 310                 315                 320 


Glu Ser Arg Asn His Phe Leu Lys Asn Pro Arg Phe Phe Pro Pro Asn 
                325                 330                 335     


Thr Arg Tyr Gly Gly Lys Ser Leu Val Phe Pro Pro Lys Lys Pro Ala 
            340                 345                 350         


Pro Ile Gly Glu Phe Gln Ser Thr Glu Pro Glu Gln Ser Cys Ala Asp 
        355                 360                 365             


Thr Pro Val Phe Leu Ala Lys Pro Pro Ile Gly Phe Phe Thr Asp Tyr 
    370                 375                 380                 


Glu Ile Gly Pro Val Tyr Glu Met Val Ile Ala Leu Gln Asn Thr Thr 
385                 390                 395                 400 


Thr Thr Ser Arg Tyr Leu Arg Val Leu Pro Pro Ser Thr Pro Tyr Phe 
                405                 410                 415     


Ala Leu Gly Leu Gly Met Phe Pro Gly Lys Gly Gly Met Val Ala Pro 
            420                 425                 430         


Gly Met Thr Cys Gln Tyr Ile Val Gln Phe Phe Pro Asp Cys Leu Gly 
        435                 440                 445             


Asp Phe Asp Asp Phe Ile Leu Val Glu Thr Gln Ser Ala His Thr Leu 
    450                 455                 460                 


Leu Ile Pro Leu Gln Ala Arg Arg Pro Pro Pro Val Leu Thr Leu Ser 
465                 470                 475                 480 


Pro Val Leu Asp Cys Gly Tyr Cys Leu Ile Gly Gly Val Lys Met Thr 
                485                 490                 495     


Arg Phe Ile Cys Lys Asn Val Gly Phe Ser Val Gly Arg Phe Cys Ile 
            500                 505                 510         


Met Pro Lys Thr Ser Trp Pro Pro Leu Ser Phe Lys Ala Ile Ala Thr 
        515                 520                 525             


Val Gly Phe Val Glu Gln Pro Pro Phe Gly Ile Leu Pro Ser Val Phe 
    530                 535                 540                 


Glu Leu Ala Pro Gly His Ala Ile Leu Val Glu Val Leu Phe Ser Pro 
545                 550                 555                 560 


Lys Ser Leu Gly Lys Ala Glu Gln Thr Phe Ile Ile Met Cys Asp Asn 
                565                 570                 575     


Cys Gln Ile Lys Glu Leu Val Thr Ile Gly Ile Gly Gln Leu Ile Ala 
            580                 585                 590         


Leu Asp Leu Ile Tyr Ile Ser Gly Glu Lys Ser Gln Pro Asp Pro Gly 
        595                 600                 605             


Glu Leu Thr Asp Leu Thr Ala Gln His Phe Ile Arg Phe Glu Pro Glu 
    610                 615                 620                 


Asn Leu Arg Ser Thr Ala Arg Lys Gln Leu Ile Ile Arg Asn Ala Thr 
625                 630                 635                 640 


His Val Glu Leu Ala Phe Tyr Trp Gln Ile Met Lys Pro Asn Leu Gln 
                645                 650                 655     


Pro Leu Met Pro Gly Glu Thr Phe Ser Met Asp Ser Ile Lys Cys Tyr 
            660                 665                 670         


Pro Asp Lys Glu Thr Ala Phe Ser Ile Met Pro Arg Lys Gly Val Leu 
        675                 680                 685             


Ser Pro His Thr Asp His Glu Phe Ile Leu Ser Phe Ser Pro His Glu 
    690                 695                 700                 


Leu Arg Asp Phe His Ser Val Leu Gln Met Val Leu Glu Glu Val Pro 
705                 710                 715                 720 


Glu Pro Val Ser Ser Glu Ala Glu Ser Leu Gly His Ser Ser Tyr Ser 
                725                 730                 735     


Val Asp Asp Val Ile Val Leu Glu Ile Glu Val Lys Gly Ser Val Glu 
            740                 745                 750         


Pro Phe Gln Val Leu Leu Glu Pro Tyr Ala Leu Ile Ile Pro Gly Glu 
        755                 760                 765             


Asn Tyr Ile Gly Ile Asn Val Lys Lys Ala Phe Lys Met Trp Asn Asn 
    770                 775                 780                 


Ser Lys Ser Pro Ile Arg Tyr Leu Trp Gly Lys Ile Ser Asp Cys His 
785                 790                 795                 800 


Ile Ile Glu Val Glu Pro Gly Thr Gly Val Ile Glu Pro Ser Glu Val 
                805                 810                 815     


Gly Asp Phe Glu Leu Asn Phe Thr Gly Gly Val Pro Gly Pro Thr Ser 
            820                 825                 830         


Gln Asp Leu Leu Cys Glu Ile Glu Asp Ser Pro Ser Pro Val Val Leu 
        835                 840                 845             


His Ile Glu Ala Val Phe Lys Gly Pro Ala Leu Ile Ile Asn Val Ser 
    850                 855                 860                 


Ala Leu Gln Phe Gly Leu Leu Arg Leu Gly Gln Lys Ala Thr Asn Ser 
865                 870                 875                 880 


Ile Gln Ile Arg Asn Val Ser Gln Leu Pro Ala Thr Trp Arg Met Lys 
                885                 890                 895     


Glu Ser Pro Val Ser Leu Gln Glu Arg Pro Glu Asp Val Ser Pro Phe 
            900                 905                 910         


Asp Ile Glu Pro Ser Ser Gly Gln Leu His Ser Leu Gly Glu Cys Arg 
        915                 920                 925             


Val Asp Ile Thr Leu Glu Ala Leu His Cys Gln His Leu Glu Thr Val 
    930                 935                 940                 


Leu Glu Leu Glu Val Glu Asn Gly Ala Trp Ser Tyr Leu Pro Val Tyr 
945                 950                 955                 960 


Ala Glu Val Gln Lys Pro His Val Tyr Leu Gln Ser Ser Gln Val Glu 
                965                 970                 975     


Val Arg Asn Leu Tyr Leu Gly Val Pro Thr Lys Thr Thr Ile Thr Leu 
            980                 985                 990         


Ile Asn Gly Thr Leu Leu Pro Thr  Gln Phe His Trp Gly  Lys Leu Leu 
        995                 1000                 1005             


Gly His  Gln Ala Glu Phe Cys  Met Val Thr Val Ser  Pro Lys His 
    1010                 1015                 1020             


Gly Leu  Leu Gly Pro Ser Glu  Glu Cys Gln Leu Lys  Leu Glu Leu 
    1025                 1030                 1035             


Thr Ala  His Thr Gln Glu Glu  Leu Thr His Leu Ala  Leu Pro Cys 
    1040                 1045                 1050             


His Val  Ser Gly Met Lys Lys  Pro Leu Val Leu Gly  Ile Ser Gly 
    1055                 1060                 1065             


Lys Pro  Gln Gly Leu Gln Val  Ala Ile Thr Ile Ser  Lys Glu Ser 
    1070                 1075                 1080             


Ser Asp  Cys Ser Thr Glu Gln  Trp Pro Gly His Pro  Lys Glu Leu 
    1085                 1090                 1095             


Arg Leu  Asp Phe Gly Ser Ala  Val Pro Leu Arg Thr  Arg Val Thr 
    1100                 1105                 1110             


Arg Gln  Leu Ile Leu Thr Asn  Arg Ser Pro Ile Arg  Thr Arg Phe 
    1115                 1120                 1125             


Ser Leu  Lys Phe Glu Tyr Phe  Gly Ser Pro Gln Asn  Ser Leu Ser 
    1130                 1135                 1140             


Lys Lys  Thr Ser Leu Pro Asn  Met Pro Pro Ala Leu  Leu Lys Thr 
    1145                 1150                 1155             


Val Arg  Met Gln Glu His Leu  Ala Lys Arg Glu Gln  Leu Asp Phe 
    1160                 1165                 1170             


Met Glu  Ser Met Leu Ser His  Gly Lys Gly Ala Ala  Phe Phe Pro 
    1175                 1180                 1185             


His Phe  Ser Gln Gly Met Leu  Gly Pro Tyr Gln Gln  Leu Cys Ile 
    1190                 1195                 1200             


Asp Ile  Thr Gly Cys Ala Asn  Met Trp Gly Glu Tyr  Trp Asp Asn 
    1205                 1210                 1215             


Leu Ile  Cys Thr Val Gly Asp  Leu Leu Pro Glu Val  Ile Pro Val 
    1220                 1225                 1230             


His Met  Ala Ala Val Gly Cys  Pro Ile Ser Ser Leu  Arg Thr Thr 
    1235                 1240                 1245             


Ser Tyr  Thr Ile Asp Gln Ala  Gln Lys Glu Pro Ala  Met Arg Phe 
    1250                 1255                 1260             


Gly Thr  Gln Val Ser Gly Gly  Asp Thr Val Thr Arg  Thr Leu Arg 
    1265                 1270                 1275             


Leu Asn  Asn Ser Ser Pro Cys  Asp Ile Arg Leu Asp  Trp Glu Thr 
    1280                 1285                 1290             


Tyr Val  Pro Glu Asp Lys Glu  Asp Arg Leu Val Glu  Leu Leu Val 
    1295                 1300                 1305             


Phe Tyr  Gly Pro Pro Phe Pro  Leu Arg Asp Gln Ala  Gly Asn Glu 
    1310                 1315                 1320             


Leu Val  Cys Pro Asp Thr Pro  Glu Gly Gly Cys Leu  Leu Trp Ser 
    1325                 1330                 1335             


Pro Gly  Pro Ser Ser Ser Ser  Glu Phe Ser His Glu  Thr Asp Ser 
    1340                 1345                 1350             


Ser Val  Glu Gly Ser Ser Ser  Ala Ser Asn Arg Val  Ala Gln Lys 
    1355                 1360                 1365             


Leu Ile  Ser Val Ile Leu Gln  Ala His Glu Gly Val  Pro Ser Gly 
    1370                 1375                 1380             


His Leu  Tyr Cys Ile Ser Pro  Lys Gln Val Val Val  Pro Ala Gly 
    1385                 1390                 1395             


Gly Ser  Ser Thr Ile Tyr Ile  Ser Phe Thr Pro Met  Val Leu Ser 
    1400                 1405                 1410             


Pro Glu  Ile Leu His Lys Val  Glu Cys Thr Gly Tyr  Ala Leu Gly 
    1415                 1420                 1425             


Phe Met  Ser Leu Asp Ser Lys  Val Glu Arg Glu Ile  Pro Gly Lys 
    1430                 1435                 1440             


Arg His  Arg Leu Gln Asp Phe  Ala Val Gly Pro Leu  Lys Leu Asp 
    1445                 1450                 1455             


Leu His  Ser Tyr Val Arg Pro  Ala Gln Leu Ser Val  Glu Leu Asp 
    1460                 1465                 1470             


Tyr Gly  Gly Ser Met Glu Phe  Gln Cys Gln Ala Ser  Asp Leu Ile 
    1475                 1480                 1485             


Pro Glu  Gln Pro Cys Ser Gly  Val Leu Ser Glu Leu  Val Thr Thr 
    1490                 1495                 1500             


His His  Leu Lys Leu Thr Asn  Thr Thr Glu Ile Pro  His Tyr Phe 
    1505                 1510                 1515             


Arg Leu  Met Val Ser Arg Pro  Phe Ser Val Ser Gln  Asp Gly Ala 
    1520                 1525                 1530             


Ser Gln  Asp His Arg Ala Pro  Gly Pro Gly Gln Lys  Gln Glu Cys 
    1535                 1540                 1545             


Glu Glu  Glu Thr Ala Ser Ala  Asp Lys Gln Leu Val  Leu Gln Ala 
    1550                 1555                 1560             


Gln Glu  Asn Met Leu Val Asn  Val Ser Phe Ser Leu  Ser Leu Glu 
    1565                 1570                 1575             


Leu Leu  Ser Tyr Gln Lys Leu  Pro Ala Asp Gln Thr  Leu Pro Gly 
    1580                 1585                 1590             


Val Asp  Ile Gln Gln Ser Ala  Ser Gly Glu Arg Glu  Met Val Phe 
    1595                 1600                 1605             


Thr Gln  Asn Leu Leu Leu Glu  Tyr Thr Asn Gln Thr  Thr Gln Val 
    1610                 1615                 1620             


Val Pro  Leu Arg Ala Val Val  Ala Val Pro Glu Leu  Gln Leu Ser 
    1625                 1630                 1635             


Thr Ser  Trp Val Asp Phe Gly  Thr Cys Phe Val Ser  Gln Gln Arg 
    1640                 1645                 1650             


Val Arg  Glu Val Tyr Leu Met  Asn Leu Ser Gly Cys  Arg Ser Tyr 
    1655                 1660                 1665             


Trp Thr  Met Leu Met Gly Gln  Gln Glu Pro Ala Lys  Ala Ala Val 
    1670                 1675                 1680             


Ala Phe  Arg Val Ser Pro Asn  Ser Gly Leu Leu Glu  Ala Arg Ser 
    1685                 1690                 1695             


Ala Asn  Ala Pro Pro Thr Ser  Ile Ala Leu Gln Val  Phe Phe Thr 
    1700                 1705                 1710             


Ala Arg  Ser Ser Glu Leu Tyr  Glu Ser Thr Met Val  Val Glu Gly 
    1715                 1720                 1725             


Val Leu  Gly Glu Lys Ser Cys  Thr Leu Arg Leu Arg  Gly Gln Gly 
    1730                 1735                 1740             


Ser Tyr  Asp Glu Arg Tyr Met  Leu Pro His Gln Pro  
    1745                 1750                 1755 


<210>  3096
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLEU7__Homo_sapiens__NP_945340

<400>  3096

Met Ala Ser Pro Ala Pro Leu Val Ala Ser Ile Ser His Gln Met Val 
1               5                   10                  15      


Ala Leu Gln Thr Leu Gln Leu Leu Gln Gln Glu Trp Gly Trp Gly Asp 
            20                  25                  30          


Gly Pro Val Ala Pro Gly Asn Pro Arg Asp Pro Asp His Val Ser Thr 
        35                  40                  45              


Ala Pro Ala Arg Arg Ser Gly Pro Pro Arg Ala Arg Pro Gly Pro Gly 
    50                  55                  60                  


Arg Glu Glu Arg Gly Gly Gly Val Gly Thr Arg Ser Arg Arg Thr Ala 
65                  70                  75                  80  


Ala Arg Ala Asn Ser Pro Glu Glu Glu Val Val Arg Gly Ala Glu Gly 
                85                  90                  95      


Gly Ala Glu Leu Leu Pro Phe Pro Arg Asp Arg Gly Pro Cys Thr Leu 
            100                 105                 110         


Ala Gln Met Ala Met Arg Ser Ala Leu Ala Arg Val Val Asp Ser Thr 
        115                 120                 125             


Ser Glu Leu Val Ser Val Glu Gln Thr Leu Leu Gly Pro Leu Gln Gln 
    130                 135                 140                 


Glu Arg Ser Phe Pro Ile His Leu Lys Leu Gln Leu Leu Ala Asn Glu 
145                 150                 155                 160 


<210>  3097
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLG1__Homo_sapiens__NP_001191315

<400>  3097

Met Pro Val Arg Lys Gln Asp Thr Gln Arg Ala Leu His Leu Leu Glu 
1               5                   10                  15      


Glu Tyr Arg Ser Lys Leu Ser Gln Thr Glu Asp Arg Gln Leu Arg Ser 
            20                  25                  30          


Ser Ile Glu Arg Val Ile Asn Ile Phe Gln Ser Asn Leu Phe Gln Ala 
        35                  40                  45              


Leu Ile Asp Ile Gln Glu Phe Tyr Glu Val Thr Leu Leu Asp Asn Pro 
    50                  55                  60                  


Lys Cys Ile Asp Arg Ser Lys Pro Ser Glu Pro Ile Gln Pro Val Asn 
65                  70                  75                  80  


Thr Trp Glu Ile Ser Ser Leu Pro Ser Ser Thr Val Thr Ser Glu Thr 
                85                  90                  95      


Leu Pro Ser Ser Leu Ser Pro Ser Val Glu Lys Tyr Arg Tyr Gln Asp 
            100                 105                 110         


Glu Asp Thr Pro Pro Gln Glu His Ile Ser Pro Gln Ile Thr Asn Glu 
        115                 120                 125             


Val Ile Gly Pro Glu Leu Val His Val Ser Glu Lys Asn Leu Ser Glu 
    130                 135                 140                 


Ile Glu Asn Val His Gly Phe Val Ser His Ser His Ile Ser Pro Ile 
145                 150                 155                 160 


Lys Ala Asn Pro Pro Pro Val Leu Val Asn Thr Asp Ser Leu Glu Thr 
                165                 170                 175     


Pro Thr Tyr Val Asn Gly Thr Asp Ala Asp Tyr Glu Tyr Glu Glu Ile 
            180                 185                 190         


Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly 
        195                 200                 205             


Thr Asp Asn Pro His Ile Gly Asp Asp Ser Ser Ile Phe Ile Thr Lys 
    210                 215                 220                 


Ile Ile Thr Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn 
225                 230                 235                 240 


Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Arg Asp Val Thr His 
                245                 250                 255     


Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu 
            260                 265                 270         


Tyr Val Lys Arg Arg Lys Pro Val Ser Glu Lys Ile Met Glu Ile Lys 
        275                 280                 285             


Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val 
    290                 295                 300                 


Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile 
305                 310                 315                 320 


Ile Glu Gly Gly Ala Ala His Lys Asp Gly Lys Leu Gln Ile Gly Asp 
                325                 330                 335     


Lys Leu Leu Ala Val Asn Asn Val Cys Leu Glu Glu Val Thr His Glu 
            340                 345                 350         


Glu Ala Val Thr Ala Leu Lys Asn Thr Ser Asp Phe Val Tyr Leu Lys 
        355                 360                 365             


Val Ala Lys Pro Thr Ser Met Tyr Met Asn Asp Gly Tyr Ala Pro Pro 
    370                 375                 380                 


Asp Ile Thr Asn Ser Ser Ser Gln Pro Val Asp Asn His Val Ser Pro 
385                 390                 395                 400 


Ser Ser Phe Leu Gly Gln Thr Pro Ala Ser Pro Ala Arg Tyr Ser Pro 
                405                 410                 415     


Val Ser Lys Ala Val Leu Gly Asp Asp Glu Ile Thr Arg Glu Pro Arg 
            420                 425                 430         


Lys Val Val Leu His Arg Gly Ser Thr Gly Leu Gly Phe Asn Ile Val 
        435                 440                 445             


Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile Leu Ala Gly 
    450                 455                 460                 


Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp Arg Ile Ile 
465                 470                 475                 480 


Ser Val Asn Ser Val Asp Leu Arg Ala Ala Ser His Glu Gln Ala Ala 
                485                 490                 495     


Ala Ala Leu Lys Asn Ala Gly Gln Ala Val Thr Ile Val Ala Gln Tyr 
            500                 505                 510         


Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His Asp Leu Arg 
        515                 520                 525             


Glu Gln Met Met Asn Ser Ser Ile Ser Ser Gly Ser Gly Ser Leu Arg 
    530                 535                 540                 


Thr Ser Gln Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe Asp Tyr Asp 
545                 550                 555                 560 


Lys Thr Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu Asn Phe Lys Phe 
                565                 570                 575     


Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp Trp Gln 
            580                 585                 590         


Ala Arg Gln Val Thr Pro Asp Gly Glu Ser Asp Glu Val Gly Val Ile 
        595                 600                 605             


Pro Ser Lys Arg Arg Val Glu Lys Lys Glu Arg Ala Arg Leu Lys Thr 
    610                 615                 620                 


Val Lys Phe Asn Ser Lys Thr Arg Asp Lys Gly Ser Phe Asn Asp Lys 
625                 630                 635                 640 


Arg Lys Lys Asn Leu Phe Ser Arg Lys Phe Pro Phe Tyr Lys Asn Lys 
                645                 650                 655     


Asp Gln Ser Glu Gln Glu Thr Ser Asp Ala Asp Gln His Val Thr Ser 
            660                 665                 670         


Asn Ala Ser Asp Ser Glu Ser Ser Tyr Arg Gly Gln Glu Glu Tyr Val 
        675                 680                 685             


Leu Ser Tyr Glu Pro Val Asn Gln Gln Glu Val Asn Tyr Thr Arg Pro 
    690                 695                 700                 


Val Ile Ile Leu Gly Pro Met Lys Asp Arg Ile Asn Asp Asp Leu Ile 
705                 710                 715                 720 


Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr Arg 
                725                 730                 735     


Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp Tyr His Phe Val Thr 
            740                 745                 750         


Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Glu His Lys Phe Ile Glu 
        755                 760                 765             


Ala Gly Gln Tyr Asn Asn His Leu Tyr Gly Thr Ser Val Gln Ser Val 
    770                 775                 780                 


Arg Glu Val Ala Glu Lys Gly Lys His Cys Ile Leu Asp Val Ser Gly 
785                 790                 795                 800 


Asn Ala Ile Lys Arg Leu Gln Ile Ala Gln Leu Tyr Pro Ile Ser Ile 
                805                 810                 815     


Phe Ile Lys Pro Lys Ser Met Glu Asn Ile Met Glu Met Asn Lys Arg 
            820                 825                 830         


Leu Thr Glu Glu Gln Ala Arg Lys Thr Phe Glu Arg Ala Met Lys Leu 
        835                 840                 845             


Glu Gln Glu Phe Thr Glu His Phe Thr Ala Ile Val Gln Gly Asp Thr 
    850                 855                 860                 


Leu Glu Asp Ile Tyr Asn Gln Val Lys Gln Ile Ile Glu Glu Gln Ser 
865                 870                 875                 880 


Gly Ser Tyr Ile Trp Val Pro Ala Lys Glu Lys Leu 
                885                 890         


<210>  3098
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLG2__Homo_sapiens__NP_001136172

<400>  3098

Met Gln Arg Pro Ser Val Ser Arg Ala Glu Asn Tyr Gln Leu Leu Trp 
1               5                   10                  15      


Asp Thr Ile Ala Ser Leu Lys Gln Cys Glu Gln Ala Met Gln His Ala 
            20                  25                  30          


Phe Ile Pro Val Asn Gly Thr Glu Ile Glu Tyr Glu Phe Glu Glu Ile 
        35                  40                  45              


Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly 
    50                  55                  60                  


Thr Asp Asn Pro His Ile Gly Asp Asp Pro Gly Ile Phe Ile Thr Lys 
65                  70                  75                  80  


Ile Ile Pro Gly Gly Ala Ala Ala Glu Asp Gly Arg Leu Arg Val Asn 
                85                  90                  95      


Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Ser Glu Val Ser His 
            100                 105                 110         


Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu 
        115                 120                 125             


Tyr Val Arg Arg Arg Arg Pro Ile Leu Glu Thr Val Val Glu Ile Lys 
    130                 135                 140                 


Leu Phe Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val 
145                 150                 155                 160 


Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile 
                165                 170                 175     


Ile Asp Gly Gly Ala Ala Gln Lys Asp Gly Arg Leu Gln Val Gly Asp 
            180                 185                 190         


Arg Leu Leu Met Val Asn Asn Tyr Ser Leu Glu Glu Val Thr His Glu 
        195                 200                 205             


Glu Ala Val Ala Ile Leu Lys Asn Thr Ser Glu Val Val Tyr Leu Lys 
    210                 215                 220                 


Val Gly Lys Pro Thr Thr Ile Tyr Met Thr Asp Pro Tyr Gly Pro Pro 
225                 230                 235                 240 


Asp Ile Thr His Ser Tyr Ser Pro Pro Met Glu Asn His Leu Leu Ser 
                245                 250                 255     


Gly Asn Asn Gly Thr Leu Glu Tyr Lys Thr Ser Leu Pro Pro Ile Ser 
            260                 265                 270         


Pro Gly Arg Tyr Ser Pro Ile Pro Lys His Met Leu Val Asp Asp Asp 
        275                 280                 285             


Tyr Thr Ser His Ser Gln His Ser Thr Ala Thr Arg Gln Pro Ser Met 
    290                 295                 300                 


Thr Leu Gln Arg Ala Val Ser Leu Glu Gly Glu Pro Arg Lys Val Val 
305                 310                 315                 320 


Leu His Lys Gly Ser Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu 
                325                 330                 335     


Asp Gly Glu Gly Ile Phe Val Ser Phe Ile Leu Ala Gly Gly Pro Ala 
            340                 345                 350         


Asp Leu Ser Gly Glu Leu Gln Arg Gly Asp Gln Ile Leu Ser Val Asn 
        355                 360                 365             


Gly Ile Asp Leu Arg Gly Ala Ser His Glu Gln Ala Ala Ala Ala Leu 
    370                 375                 380                 


Lys Gly Ala Gly Gln Thr Val Thr Ile Ile Ala Gln Tyr Gln Pro Glu 
385                 390                 395                 400 


Asp Tyr Ala Arg Phe Glu Ala Lys Ile His Asp Leu Arg Glu Gln Met 
                405                 410                 415     


Met Asn His Ser Met Ser Ser Gly Ser Gly Ser Leu Arg Thr Asn Gln 
            420                 425                 430         


Lys Arg Ser Leu Tyr Val Arg Ala Met Phe Asp Tyr Asp Lys Ser Lys 
        435                 440                 445             


Asp Ser Gly Leu Pro Ser Gln Gly Leu Ser Phe Lys Tyr Gly Asp Ile 
    450                 455                 460                 


Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp Trp Gln Ala Arg Arg 
465                 470                 475                 480 


Val Met Leu Glu Gly Asp Ser Glu Glu Met Gly Val Ile Pro Ser Lys 
                485                 490                 495     


Arg Arg Val Glu Arg Lys Glu Arg Ala Arg Leu Lys Thr Val Lys Phe 
            500                 505                 510         


Asn Ala Lys Pro Gly Val Ile Asp Ser Lys Gly Asp Ile Pro Gly Leu 
        515                 520                 525             


Gly Asp Asp Gly Tyr Gly Thr Lys Thr Leu Arg Gly Gln Glu Asp Leu 
    530                 535                 540                 


Ile Leu Ser Tyr Glu Pro Val Thr Arg Gln Glu Ile Asn Tyr Thr Arg 
545                 550                 555                 560 


Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Ile Asn Asp Asp Leu 
                565                 570                 575     


Ile Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His Thr Thr 
            580                 585                 590         


Arg Pro Lys Arg Asp Tyr Glu Val Asp Gly Arg Asp Tyr His Phe Val 
        595                 600                 605             


Ile Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Glu His Lys Phe Ile 
    610                 615                 620                 


Glu Ala Gly Gln Tyr Asn Asp Asn Leu Tyr Gly Thr Ser Val Gln Ser 
625                 630                 635                 640 


Val Arg Phe Val Ala Glu Arg Gly Lys His Cys Ile Leu Asp Val Ser 
                645                 650                 655     


Gly Asn Ala Ile Lys Arg Leu Gln Val Ala Gln Leu Tyr Pro Ile Ala 
            660                 665                 670         


Ile Phe Ile Lys Pro Arg Ser Leu Glu Pro Leu Met Glu Met Asn Lys 
        675                 680                 685             


Arg Leu Thr Glu Glu Gln Ala Lys Lys Thr Tyr Asp Arg Ala Ile Lys 
    690                 695                 700                 


Leu Glu Gln Glu Phe Gly Glu Tyr Phe Thr Ala Ile Val Gln Gly Asp 
705                 710                 715                 720 


Thr Leu Glu Asp Ile Tyr Asn Gln Cys Lys Leu Val Ile Glu Glu Gln 
                725                 730                 735     


Ser Gly Pro Phe Ile Trp Ile Pro Ser Lys Glu Lys Leu 
            740                 745                 


<210>  3099
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLG3__Homo_sapiens__NP_001159750

<400>  3099

Met Met Asn Ser Ser Met Ser Ser Gly Ser Gly Ser Leu Arg Thr Ser 
1               5                   10                  15      


Glu Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe Asp Tyr Asp Arg Thr 
            20                  25                  30          


Arg Asp Ser Cys Leu Pro Ser Gln Gly Leu Ser Phe Ser Tyr Gly Asp 
        35                  40                  45              


Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu Trp Trp Gln Ala Arg 
    50                  55                  60                  


Leu Val Thr Pro His Gly Glu Ser Glu Gln Ile Gly Val Ile Pro Ser 
65                  70                  75                  80  


Lys Lys Arg Val Glu Lys Lys Glu Arg Ala Arg Leu Lys Thr Val Lys 
                85                  90                  95      


Phe His Ala Arg Thr Gly Met Ile Glu Ser Asn Arg Ser Ile Lys Thr 
            100                 105                 110         


Lys Arg Lys Lys Ser Phe Arg Leu Ser Arg Lys Phe Pro Phe Tyr Lys 
        115                 120                 125             


Ser Lys Glu Asn Met Ala Gln Glu Ser Ser Ile Gln Glu Gln Gly Val 
    130                 135                 140                 


Thr Ser Asn Thr Ser Asp Ser Glu Ser Ser Ser Lys Gly Gln Glu Asp 
145                 150                 155                 160 


Ala Ile Leu Ser Tyr Glu Pro Val Thr Arg Gln Glu Ile His Tyr Ala 
                165                 170                 175     


Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Val Asn Asp Asp 
            180                 185                 190         


Leu Ile Ser Glu Phe Pro His Lys Phe Gly Ser Cys Val Pro His Thr 
        195                 200                 205             


Thr Arg Pro Arg Arg Asp Asn Glu Val Asp Gly Gln Asp Tyr His Phe 
    210                 215                 220                 


Val Val Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Asp Asn Lys Phe 
225                 230                 235                 240 


Ile Glu Ala Gly Gln Phe Asn Asp Asn Leu Tyr Gly Thr Ser Ile Gln 
                245                 250                 255     


Ser Val Arg Ala Val Ala Glu Arg Gly Lys His Cys Ile Leu Asp Val 
            260                 265                 270         


Ser Gly Asn Ala Ile Lys Arg Leu Gln Gln Ala Gln Leu Tyr Pro Ile 
        275                 280                 285             


Ala Ile Phe Ile Lys Pro Lys Ser Ile Glu Ala Leu Met Glu Met Asn 
    290                 295                 300                 


Arg Arg Gln Thr Tyr Glu Gln Ala Asn Lys Ile Tyr Asp Lys Ala Met 
305                 310                 315                 320 


Lys Leu Glu Gln Glu Phe Gly Glu Tyr Phe Thr Ala Ile Val Gln Gly 
                325                 330                 335     


Asp Ser Leu Glu Glu Ile Tyr Asn Lys Ile Lys Gln Ile Ile Glu Asp 
            340                 345                 350         


Gln Ser Gly His Tyr Ile Trp Val Pro Ser Pro Glu Lys Leu 
        355                 360                 365     


<210>  3100
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLG4__Homo_sapiens__NP_001122299

<400>  3100

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr 
    50                  55                  60                  


Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr 
65                  70                  75                  80  


Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile 
                85                  90                  95      


Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp 
            100                 105                 110         


Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser 
        115                 120                 125             


Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr 
    130                 135                 140                 


Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu 
145                 150                 155                 160 


Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly 
                165                 170                 175     


Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile 
            180                 185                 190         


Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys 
        195                 200                 205             


Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp 
    210                 215                 220                 


Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val 
225                 230                 235                 240 


Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp 
                245                 250                 255     


Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser 
            260                 265                 270         


Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro 
        275                 280                 285             


Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile 
    290                 295                 300                 


Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu 
305                 310                 315                 320 


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
                325                 330                 335     


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
            340                 345                 350         


Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser 
        355                 360                 365             


His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr 
    370                 375                 380                 


Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
385                 390                 395                 400 


Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly 
                405                 410                 415     


Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala 
            420                 425                 430         


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala 
        435                 440                 445             


Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp 
    450                 455                 460                 


Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp 
465                 470                 475                 480 


Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp 
                485                 490                 495     


Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly 
            500                 505                 510         


Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val 
        515                 520                 525             


His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala 
    530                 535                 540                 


Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val 
545                 550                 555                 560 


Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp 
                565                 570                 575     


Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala 
            580                 585                 590         


His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr 
        595                 600                 605             


Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile 
    610                 615                 620                 


Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu 
625                 630                 635                 640 


His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu 
                645                 650                 655     


Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp 
            660                 665                 670         


Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile 
        675                 680                 685             


Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val 
    690                 695                 700                 


Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg 
705                 710                 715                 720 


Leu 
    


<210>  3101
<211>  1919
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLG5__Homo_sapiens__NP_004738

<400>  3101

Met Glu Pro Gln Arg Arg Glu Leu Leu Ala Gln Cys Gln Gln Ser Leu 
1               5                   10                  15      


Ala Gln Ala Met Thr Glu Val Glu Ala Val Leu Gly Leu Leu Glu Ala 
            20                  25                  30          


Ala Gly Ala Leu Ser Pro Gly Glu Arg Arg Gln Leu Asp Glu Glu Ala 
        35                  40                  45              


Gly Gly Ala Lys Ala Glu Leu Leu Leu Lys Leu Leu Leu Ala Lys Glu 
    50                  55                  60                  


Arg Asp His Phe Gln Asp Leu Arg Ala Ala Leu Glu Lys Thr Gln Pro 
65                  70                  75                  80  


His Leu Leu Pro Ile Leu Tyr Leu Asn Gly Val Val Gly Pro Pro Gln 
                85                  90                  95      


Pro Ala Glu Gly Ala Gly Ser Thr Tyr Ser Val Leu Ser Thr Met Pro 
            100                 105                 110         


Ser Asp Ser Glu Ser Ser Ser Ser Leu Ser Ser Val Gly Thr Thr Gly 
        115                 120                 125             


Lys Ala Pro Ser Pro Pro Pro Leu Leu Thr Asp Gln Gln Val Asn Glu 
    130                 135                 140                 


Lys Val Glu Asn Leu Ser Ile Gln Leu Arg Leu Met Thr Arg Glu Arg 
145                 150                 155                 160 


Asn Glu Leu Arg Lys Arg Leu Ala Phe Ala Thr His Gly Thr Ala Phe 
                165                 170                 175     


Asp Lys Arg Pro Tyr His Arg Leu Asn Pro Asp Tyr Glu Arg Leu Lys 
            180                 185                 190         


Ile Gln Cys Val Arg Ala Met Ser Asp Leu Gln Ser Leu Gln Asn Gln 
        195                 200                 205             


His Thr Asn Ala Leu Lys Arg Cys Glu Glu Val Ala Lys Glu Thr Asp 
    210                 215                 220                 


Phe Tyr His Thr Leu His Ser Arg Leu Leu Ser Asp Gln Thr Arg Leu 
225                 230                 235                 240 


Lys Asp Asp Val Asp Met Leu Arg Arg Glu Asn Gly Gln Leu Leu Arg 
                245                 250                 255     


Glu Arg Asn Leu Leu Gln Gln Ser Trp Glu Asp Met Lys Arg Leu His 
            260                 265                 270         


Glu Glu Asp Gln Lys Glu Ile Gly Asp Leu Arg Ala Gln Gln Gln Gln 
        275                 280                 285             


Val Leu Lys His Asn Gly Ser Ser Glu Ile Leu Asn Lys Leu Tyr Asp 
    290                 295                 300                 


Thr Ala Met Asp Lys Leu Glu Val Val Lys Lys Asp Tyr Asp Ala Leu 
305                 310                 315                 320 


Arg Lys Arg Tyr Ser Glu Lys Val Ala Ile His Asn Ala Asp Leu Ser 
                325                 330                 335     


Arg Leu Glu Gln Leu Gly Glu Glu Asn Gln Arg Leu Leu Lys Gln Thr 
            340                 345                 350         


Glu Met Leu Thr Gln Gln Arg Asp Thr Ala Ile Gln Leu Gln His Gln 
        355                 360                 365             


Cys Ala Leu Ser Leu Arg Arg Phe Glu Ala Ile His His Glu Leu Asn 
    370                 375                 380                 


Lys Ala Thr Ala Gln Asn Lys Asp Leu Gln Trp Glu Met Glu Leu Leu 
385                 390                 395                 400 


Gln Ser Glu Leu Thr Glu Leu Arg Thr Thr Gln Val Lys Thr Ala Lys 
                405                 410                 415     


Glu Ser Glu Lys Tyr Arg Glu Glu Arg Asp Ala Val Tyr Ser Glu Tyr 
            420                 425                 430         


Lys Leu Ile Met Ser Glu Arg Asp Gln Val Ile Ser Glu Leu Asp Lys 
        435                 440                 445             


Leu Gln Thr Glu Val Glu Leu Ala Glu Ser Lys Leu Lys Ser Ser Thr 
    450                 455                 460                 


Ser Glu Lys Lys Ala Ala Asn Glu Glu Met Glu Ala Leu Arg Gln Ile 
465                 470                 475                 480 


Lys Asp Thr Val Thr Met Asp Ala Gly Arg Ala Asn Lys Glu Val Glu 
                485                 490                 495     


Ile Leu Arg Lys Gln Cys Lys Ala Leu Cys Gln Glu Leu Lys Glu Ala 
            500                 505                 510         


Leu Gln Glu Ala Asp Val Ala Lys Cys Arg Arg Asp Trp Ala Phe Gln 
        515                 520                 525             


Glu Arg Asp Lys Ile Val Ala Glu Arg Asp Ser Ile Arg Thr Leu Cys 
    530                 535                 540                 


Asp Asn Leu Arg Arg Glu Arg Asp Arg Ala Val Ser Glu Leu Ala Glu 
545                 550                 555                 560 


Ala Leu Arg Ser Leu Asp Asp Thr Arg Lys Gln Lys Asn Asp Val Ser 
                565                 570                 575     


Arg Glu Leu Lys Glu Leu Lys Glu Gln Met Glu Ser Gln Leu Glu Lys 
            580                 585                 590         


Glu Ala Arg Phe Arg Gln Leu Met Ala His Ser Ser His Asp Ser Ala 
        595                 600                 605             


Ile Asp Thr Asp Ser Met Glu Trp Glu Thr Glu Val Val Glu Phe Glu 
    610                 615                 620                 


Arg Glu Thr Glu Asp Ile Asp Leu Lys Ala Leu Gly Phe Asp Met Ala 
625                 630                 635                 640 


Glu Gly Val Asn Glu Pro Cys Phe Pro Gly Asp Cys Gly Ile Phe Val 
                645                 650                 655     


Thr Lys Val Asp Lys Gly Ser Ile Ala Asp Gly Arg Leu Arg Val Asn 
            660                 665                 670         


Asp Trp Leu Leu Arg Ile Asn Asp Val Asp Leu Ile Asn Lys Asp Lys 
        675                 680                 685             


Lys Gln Ala Ile Lys Ala Leu Leu Asn Gly Glu Gly Ala Ile Asn Met 
    690                 695                 700                 


Val Val Arg Arg Arg Lys Ser Leu Gly Gly Lys Val Val Thr Pro Leu 
705                 710                 715                 720 


His Ile Asn Leu Ser Gly Gln Lys Asp Ser Gly Ile Ser Leu Glu Asn 
                725                 730                 735     


Gly Val Tyr Ala Ala Ala Val Leu Pro Gly Ser Pro Ala Ala Lys Glu 
            740                 745                 750         


Gly Ser Leu Ala Val Gly Asp Arg Ile Val Ala Ile Asn Gly Ile Ala 
        755                 760                 765             


Leu Asp Asn Lys Ser Leu Asn Glu Cys Glu Ser Leu Leu Arg Ser Cys 
    770                 775                 780                 


Gln Asp Ser Leu Thr Leu Ser Leu Leu Lys Val Phe Pro Gln Ser Ser 
785                 790                 795                 800 


Ser Trp Ser Gly Gln Asn Ile Phe Glu Asn Ile Lys Asp Ser Asp Lys 
                805                 810                 815     


Met Leu Ser Phe Arg Ala His Gly Pro Glu Val Gln Ala His Asn Lys 
            820                 825                 830         


Arg Asn Leu Ile Gln His Asn Asn Ser Thr Gln Thr Asp Ile Phe Tyr 
        835                 840                 845             


Thr Asp Arg Leu Glu Asp Arg Lys Glu Pro Gly Pro Pro Gly Gly Ser 
    850                 855                 860                 


Ser Ser Phe Leu His Lys Pro Phe Pro Gly Gly Pro Leu Gln Val Cys 
865                 870                 875                 880 


Pro Gln Ala Cys Pro Ser Ala Ser Glu Arg Ser Leu Ser Ser Phe Arg 
                885                 890                 895     


Ser Asp Ala Ser Gly Asp Arg Gly Phe Gly Leu Val Asp Val Arg Gly 
            900                 905                 910         


Arg Arg Pro Leu Leu Pro Phe Glu Thr Glu Val Gly Pro Cys Gly Val 
        915                 920                 925             


Gly Glu Ala Ser Leu Asp Lys Ala Asp Ser Glu Gly Ser Asn Ser Gly 
    930                 935                 940                 


Gly Thr Trp Pro Lys Ala Met Leu Ser Ser Thr Ala Val Pro Glu Lys 
945                 950                 955                 960 


Leu Ser Val Tyr Lys Lys Pro Lys Gln Arg Lys Ser Ile Phe Asp Pro 
                965                 970                 975     


Asn Thr Phe Lys Arg Pro Gln Thr Pro Pro Lys Ile Asp Tyr Leu Leu 
            980                 985                 990         


Pro Gly Pro Gly Pro Ala His Ser  Pro Gln Pro Ser Lys  Arg Ala Gly 
        995                 1000                 1005             


Pro Leu  Thr Pro Pro Lys Pro  Pro Arg Arg Ser Asp  Ser Ile Lys 
    1010                 1015                 1020             


Phe Gln  His Arg Leu Glu Thr  Ser Ser Glu Ser Glu  Ala Thr Leu 
    1025                 1030                 1035             


Val Gly  Ser Ser Pro Ser Thr  Ser Pro Pro Ser Ala  Leu Pro Pro 
    1040                 1045                 1050             


Asp Val  Asp Pro Gly Glu Pro  Met His Ala Ser Pro  Pro Arg Lys 
    1055                 1060                 1065             


Ala Arg  Val Arg Ile Ala Ser  Ser Tyr Tyr Pro Glu  Gly Asp Gly 
    1070                 1075                 1080             


Asp Ser  Ser His Leu Pro Ala  Lys Lys Ser Cys Asp  Glu Asp Leu 
    1085                 1090                 1095             


Thr Ser  Gln Lys Val Asp Glu  Leu Gly Gln Lys Arg  Arg Arg Pro 
    1100                 1105                 1110             


Lys Ser  Ala Pro Ser Phe Arg  Pro Lys Leu Ala Pro  Val Val Ile 
    1115                 1120                 1125             


Pro Ala  Gln Phe Leu Glu Glu  Gln Lys Cys Val Pro  Ala Ser Gly 
    1130                 1135                 1140             


Glu Leu  Ser Pro Glu Leu Gln  Glu Trp Ala Pro Tyr  Ser Pro Gly 
    1145                 1150                 1155             


His Ser  Ser Arg His Ser Asn  Pro Pro Leu Tyr Pro  Ser Arg Pro 
    1160                 1165                 1170             


Ser Val  Gly Thr Val Pro Arg  Ser Leu Thr Pro Ser  Thr Thr Val 
    1175                 1180                 1185             


Ser Ser  Ile Leu Arg Asn Pro  Ile Tyr Thr Val Arg  Ser His Arg 
    1190                 1195                 1200             


Val Gly  Pro Cys Ser Ser Pro  Pro Ala Ala Arg Asp  Ala Gly Pro 
    1205                 1210                 1215             


Gln Gly  Leu His Pro Ser Val  Gln His Gln Gly Arg  Leu Ser Leu 
    1220                 1225                 1230             


Asp Leu  Ser His Arg Thr Cys  Ser Asp Tyr Ser Glu  Met Arg Ala 
    1235                 1240                 1245             


Thr His  Gly Ser Asn Ser Leu  Pro Ser Ser Ala Arg  Leu Gly Ser 
    1250                 1255                 1260             


Ser Ser  Asn Leu Gln Phe Lys  Ala Glu Arg Ile Lys  Ile Pro Ser 
    1265                 1270                 1275             


Thr Pro  Arg Tyr Pro Arg Ser  Val Val Gly Ser Glu  Arg Gly Ser 
    1280                 1285                 1290             


Val Ser  His Ser Glu Cys Ser  Thr Pro Pro Gln Ser  Pro Leu Asn 
    1295                 1300                 1305             


Ile Asp  Thr Leu Ser Ser Cys  Ser Gln Ser Gln Thr  Ser Ala Ser 
    1310                 1315                 1320             


Thr Leu  Pro Arg Ile Ala Val  Asn Pro Ala Ser Leu  Gly Glu Arg 
    1325                 1330                 1335             


Arg Lys  Asp Arg Pro Tyr Val  Glu Glu Pro Arg His  Val Lys Val 
    1340                 1345                 1350             


Gln Lys  Gly Ser Glu Pro Leu  Gly Ile Ser Ile Val  Ser Gly Glu 
    1355                 1360                 1365             


Lys Gly  Gly Ile Tyr Val Ser  Lys Val Thr Val Gly  Ser Ile Ala 
    1370                 1375                 1380             


His Gln  Ala Gly Leu Glu Tyr  Gly Asp Gln Leu Leu  Glu Phe Asn 
    1385                 1390                 1395             


Gly Ile  Asn Leu Arg Ser Ala  Thr Glu Gln Gln Ala  Arg Leu Ile 
    1400                 1405                 1410             


Ile Gly  Gln Gln Cys Asp Thr  Ile Thr Ile Leu Ala  Gln Tyr Asn 
    1415                 1420                 1425             


Pro His  Val His Gln Leu Ser  Ser His Ser Arg Ser  Ser Ser His 
    1430                 1435                 1440             


Leu Asp  Pro Ala Gly Thr His  Ser Thr Leu Gln Gly  Ser Gly Thr 
    1445                 1450                 1455             


Thr Thr  Pro Glu His Pro Ser  Val Ile Asp Pro Leu  Met Glu Gln 
    1460                 1465                 1470             


Asp Glu  Gly Pro Ser Thr Pro  Pro Ala Lys Gln Ser  Ser Ser Arg 
    1475                 1480                 1485             


Ile Ala  Gly Asp Ala Asn Lys  Lys Thr Leu Glu Pro  Arg Val Val 
    1490                 1495                 1500             


Phe Ile  Lys Lys Ser Gln Leu  Glu Leu Gly Val His  Leu Cys Gly 
    1505                 1510                 1515             


Gly Asn  Leu His Gly Val Phe  Val Ala Glu Val Glu  Asp Asp Ser 
    1520                 1525                 1530             


Pro Ala  Lys Gly Pro Asp Gly  Leu Val Pro Gly Asp  Leu Ile Leu 
    1535                 1540                 1545             


Glu Tyr  Gly Ser Leu Asp Val  Arg Asn Lys Thr Val  Glu Glu Val 
    1550                 1555                 1560             


Tyr Val  Glu Met Leu Lys Pro  Arg Asp Gly Val Arg  Leu Lys Val 
    1565                 1570                 1575             


Gln Tyr  Arg Pro Glu Glu Phe  Thr Lys Ala Lys Gly  Leu Pro Gly 
    1580                 1585                 1590             


Asp Ser  Phe Tyr Ile Arg Ala  Leu Tyr Asp Arg Leu  Ala Asp Val 
    1595                 1600                 1605             


Glu Gln  Glu Leu Ser Phe Lys  Lys Asp Asp Ile Leu  Tyr Val Asp 
    1610                 1615                 1620             


Asp Thr  Leu Pro Gln Gly Thr  Phe Gly Ser Trp Met  Ala Trp Gln 
    1625                 1630                 1635             


Leu Asp  Glu Asn Ala Gln Lys  Ile Gln Arg Gly Gln  Ile Pro Ser 
    1640                 1645                 1650             


Lys Tyr  Val Met Asp Gln Glu  Phe Ser Arg Arg Leu  Ser Met Ser 
    1655                 1660                 1665             


Glu Val  Lys Asp Asp Asn Ser  Ala Thr Lys Thr Leu  Ser Ala Ala 
    1670                 1675                 1680             


Ala Arg  Arg Ser Phe Phe Arg  Arg Lys His Lys His  Lys Arg Ser 
    1685                 1690                 1695             


Gly Ser  Lys Asp Gly Lys Asp  Leu Leu Ala Leu Asp  Ala Phe Ser 
    1700                 1705                 1710             


Ser Asp  Ser Ile Pro Leu Phe  Glu Asp Ser Val Ser  Leu Ala Tyr 
    1715                 1720                 1725             


Gln Arg  Val Gln Lys Val Asp  Cys Thr Ala Leu Arg  Pro Val Leu 
    1730                 1735                 1740             


Ile Leu  Gly Pro Leu Leu Asp  Val Val Lys Glu Met  Leu Val Asn 
    1745                 1750                 1755             


Glu Ala  Pro Gly Lys Phe Cys  Arg Cys Pro Leu Glu  Val Met Lys 
    1760                 1765                 1770             


Ala Ser  Gln Gln Ala Ile Glu  Arg Gly Val Lys Asp  Cys Leu Phe 
    1775                 1780                 1785             


Val Asp  Tyr Lys Arg Arg Ser  Gly His Phe Asp Val  Thr Thr Val 
    1790                 1795                 1800             


Ala Ser  Ile Lys Glu Ile Thr  Glu Lys Asn Arg His  Cys Leu Leu 
    1805                 1810                 1815             


Asp Ile  Ala Pro His Ala Ile  Glu Arg Leu His His  Met His Ile 
    1820                 1825                 1830             


Tyr Pro  Ile Val Ile Phe Ile  His Tyr Lys Ser Ala  Lys His Ile 
    1835                 1840                 1845             


Lys Glu  Gln Arg Asp Pro Ile  Tyr Leu Arg Asp Lys  Val Thr Gln 
    1850                 1855                 1860             


Arg His  Ser Lys Glu Gln Phe  Glu Ala Ala Gln Lys  Leu Glu Gln 
    1865                 1870                 1875             


Glu Tyr  Ser Arg Tyr Phe Thr  Gly Val Ile Gln Gly  Gly Ala Leu 
    1880                 1885                 1890             


Ser Ser  Ile Cys Thr Gln Ile  Leu Ala Met Val Asn  Gln Glu Gln 
    1895                 1900                 1905             


Asn Lys  Val Leu Trp Ile Pro  Ala Cys Pro Leu 
    1910                 1915                 


<210>  3102
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLGAP1__Homo_sapiens__NP_001003809

<400>  3102

Met Asn Leu Ile Phe His Lys Asp Ile Leu Phe Gly Ile Pro Ala Asn 
1               5                   10                  15      


Lys Val Pro Gln Asp Glu Trp Thr Gly Tyr Thr Pro Arg Gly Lys Asp 
            20                  25                  30          


Asp Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala 
        35                  40                  45              


Met Gly Asp Glu Asp Ser Gly Asp Ser Asp Thr Ser Pro Lys Pro Ser 
    50                  55                  60                  


Pro Lys Val Ala Ala Arg Arg Glu Ser Tyr Leu Lys Ala Thr Gln Pro 
65                  70                  75                  80  


Ser Leu Thr Glu Leu Thr Thr Leu Lys Ile Ser Asn Glu His Ser Pro 
                85                  90                  95      


Lys Leu Gln Ile Arg Ser His Ser Tyr Leu Arg Ala Val Ser Glu Val 
            100                 105                 110         


Ser Ile Asn Arg Ser Leu Asp Ser Leu Asp Pro Ala Gly Leu Leu Thr 
        115                 120                 125             


Ser Pro Lys Phe Arg Ser Arg Asn Glu Ser Tyr Met Arg Ala Met Ser 
    130                 135                 140                 


Thr Ile Ser Gln Val Ser Glu Met Glu Val Asn Gly Gln Phe Glu Ser 
145                 150                 155                 160 


Val Cys Glu Ser Val Phe Ser Glu Leu Glu Ser Gln Ala Val Glu Ala 
                165                 170                 175     


Leu Asp Leu Pro Met Pro Gly Cys Phe Arg Met Arg Ser His Ser Tyr 
            180                 185                 190         


Val Arg Ala Ile Glu Lys Gly Cys Ser Gln Asp Asp Glu Cys Val Ser 
        195                 200                 205             


Leu Arg Ser Ser Ser Pro Pro Arg Thr Thr Thr Thr Val Arg Thr Ile 
    210                 215                 220                 


Gln Ser Ser Thr Val Ser Ser Cys Ile Thr Thr Tyr Lys Lys Thr Pro 
225                 230                 235                 240 


Pro Pro Val Pro Pro Arg Thr Thr Thr Lys Pro Phe Ile Ser Ile Thr 
                245                 250                 255     


Ala Gln Ser Ser Thr Glu Ser Ala Gln Asp Ala Tyr Met Asp Gly Gln 
            260                 265                 270         


Gly Gln Arg Gly Asp Ile Ile Ser Gln Ser Gly Leu Ser Asn Ser Thr 
        275                 280                 285             


Glu Ser Leu Asp Ser Met Lys Ala Leu Thr Ala Ala Ile Glu Ala Ala 
    290                 295                 300                 


Asn Ala Gln Ile His Gly Pro Ala Ser Gln His Met Gly Asn Asn Thr 
305                 310                 315                 320 


Ala Thr Val Thr Thr Thr Thr Thr Ile Ala Thr Val Thr Thr Glu Asp 
                325                 330                 335     


Arg Lys Lys Asp His Phe Lys Lys Asn Arg Cys Leu Ser Ile Gly Ile 
            340                 345                 350         


Gln Val Asp Asp Ala Glu Glu Pro Asp Lys Thr Gly Glu Asn Lys Ala 
        355                 360                 365             


Pro Ser Lys Phe Gln Ser Val Gly Val Gln Val Glu Glu Glu Lys Cys 
    370                 375                 380                 


Phe Arg Arg Phe Thr Arg Ser Asn Ser Val Thr Thr Ala Val Gln Ala 
385                 390                 395                 400 


Asp Leu Asp Phe His Asp Asn Leu Glu Asn Ser Leu Glu Ser Ile Glu 
                405                 410                 415     


Asp Asn Ser Cys Pro Gly Pro Met Ala Arg Gln Phe Ser Arg Asp Ala 
            420                 425                 430         


Ser Thr Ser Thr Val Ser Ile Gln Gly Ser Gly Asn His Tyr His Ala 
        435                 440                 445             


Cys Ala Ala Asp Asp Asp Phe Asp Thr Asp Phe Asp Pro Ser Ile Leu 
    450                 455                 460                 


Pro Pro Pro Asp Pro Trp Ile Asp Ser Ile Thr Glu Asp Pro Leu Glu 
465                 470                 475                 480 


Ala Val Gln Arg Ser Val Cys His Arg Asp Gly His Trp Phe Leu Lys 
                485                 490                 495     


Leu Leu Gln Ala Glu Arg Asp Arg Met Glu Gly Trp Cys Gln Gln Met 
            500                 505                 510         


Glu Arg Glu Glu Arg Glu Asn Asn Leu Pro Glu Asp Ile Leu Gly Lys 
        515                 520                 525             


Ile Arg Thr Ala Val Gly Ser Ala Gln Leu Leu Met Ala Gln Lys Phe 
    530                 535                 540                 


Tyr Gln Phe Arg Glu Leu Cys Glu Glu Asn Leu Asn Pro Asn Ala His 
545                 550                 555                 560 


Pro Arg Pro Thr Ser Gln Asp Leu Ala Gly Phe Trp Asp Met Leu Gln 
                565                 570                 575     


Leu Ser Ile Glu Asn Ile Ser Met Lys Phe Asp Glu Leu His Gln Leu 
            580                 585                 590         


Lys Ala Asn Asn Trp Lys Gln Met Asp Pro Leu Asp Lys Lys Glu Arg 
        595                 600                 605             


Arg Ala Pro Pro Pro Val Pro Lys Lys Pro Ala Lys Gly Pro Ala Pro 
    610                 615                 620                 


Leu Ile Arg Glu Arg Ser Leu Glu Ser Ser Gln Arg Gln Glu Ala Arg 
625                 630                 635                 640 


Lys Arg Leu Met Ala Ala Lys Arg Ala Ala Ser Val Arg Gln Asn Ser 
                645                 650                 655     


Ala Thr Glu Ser Ala Glu Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln 
            660                 665                 670         


Thr Arg Leu 
        675 


<210>  3103
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLGAP2__Homo_sapiens__XP_011533064

<400>  3103

Met Lys Gly Leu Ser Gly Ser Arg Thr Gln Pro Pro Leu Cys Ser Gly 
1               5                   10                  15      


His Thr Cys Gly Leu Ala Pro Pro Glu Asp Cys Glu His Leu His His 
            20                  25                  30          


Gly Pro Asp Ala Arg Pro Pro Tyr Leu Leu Ser Pro Ala Asp Ser Cys 
        35                  40                  45              


Pro Gly Gly Arg His Arg Cys Ser Pro Arg Ser Ser Val His Ser Glu 
    50                  55                  60                  


Cys Val Met Met Pro Val Val Leu Gly Asp His Val Ser Ser Ser Thr 
65                  70                  75                  80  


Phe Pro Arg Met His Tyr Ser Ser His Tyr Asp Thr Arg Asp Asp Cys 
                85                  90                  95      


Ala Val Ala His Ala Gly Ala Lys Ile Asn Arg Ile Pro Ala Asn Leu 
            100                 105                 110         


Leu Asp Gln Phe Glu Lys Gln Leu Pro Leu His Arg Asp Gly Phe His 
        115                 120                 125             


Thr Leu Gln Tyr Gln Arg Thr Ser Ala Ala Ala Glu Gln Arg Ser Glu 
    130                 135                 140                 


Ser Pro Gly Arg Ile Arg His Leu Val His Ser Val Gln Lys Leu Phe 
145                 150                 155                 160 


Thr Lys Ser His Ser Leu Glu Gly Ser Ser Lys Ser Asn Ala Asn Gly 
                165                 170                 175     


Thr Lys Ala Asp Gly Arg Ala Asp Asp His His His Ala His His Ala 
            180                 185                 190         


Lys His Ser Lys Arg Ser Lys Ser Lys Glu Arg Lys Pro Glu Gly Lys 
        195                 200                 205             


Pro Arg Pro Gly Met Ser Ser Trp Trp Ser Ser Asp Asp Asn Leu Asp 
    210                 215                 220                 


Ser Asp Ser Thr Tyr Arg Thr Pro Ser Val Leu Asn Arg His His Leu 
225                 230                 235                 240 


Gly Pro Val Ala His Cys Tyr Pro Asp Ala Leu Gln Ser Pro Phe Gly 
                245                 250                 255     


Asp Leu Ser Leu Lys Thr Ser Lys Ser Asn Asn Asp Val Lys Cys Ser 
            260                 265                 270         


Ala Cys Glu Gly Leu Ala Leu Thr Pro Asp Ala Lys Tyr Leu Lys Arg 
        275                 280                 285             


Ser Ser Trp Ser Thr Leu Thr Val Ser Gln Ala Lys Glu Ala Tyr Arg 
    290                 295                 300                 


Lys Ser Ser Leu Asn Leu Asp Lys Pro Leu Leu His Gln Asp Ala Lys 
305                 310                 315                 320 


Pro Ala Leu Arg Pro Cys His Tyr Leu Gln Val Pro Gln Asp Glu Trp 
                325                 330                 335     


Gly Gly Tyr Pro Thr Gly Gly Lys Asp Glu Glu Ile Pro Cys Arg Arg 
            340                 345                 350         


Met Arg Ser Gly Ser Tyr Ile Lys Ala Met Gly Asp Glu Glu Ser Gly 
        355                 360                 365             


Glu Ser Asp Ser Ser Pro Lys Thr Ser Pro Lys Ser Ala Ile Leu Pro 
    370                 375                 380                 


Glu Pro Leu Leu Lys Ser Ile Gly Gln Arg Pro Leu Gly Glu His Gln 
385                 390                 395                 400 


Thr Gln Thr Tyr Leu Gln Ala Ala Ser Asp Val Pro Val Gly His Ser 
                405                 410                 415     


Leu Asp Pro Ala Ala Asn Tyr Asn Ser Pro Lys Phe Arg Ser Arg Asn 
            420                 425                 430         


Gln Ser Tyr Met Arg Ala Val Ser Thr Leu Ser Gln Ala Ser Cys Val 
        435                 440                 445             


Ser Gln Val Ser Glu Ala Glu Ile Asn Gly Gln Phe Glu Ser Val Cys 
    450                 455                 460                 


Glu Ser Val Phe Ser Glu Val Glu Ser Gln Ala Met Asp Ala Leu Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Phe Arg Thr Arg Ser His Ser Tyr Leu Arg Ala Ile 
                485                 490                 495     


Gln Ala Gly Tyr Ser Gln Asp Asp Glu Cys Ile Pro Met Met Thr Pro 
            500                 505                 510         


Ser Asp Ile Thr Ser Thr Ile Arg Ser Thr Ala Ala Val Ser Tyr Thr 
        515                 520                 525             


Asn Tyr Lys Lys Thr Pro Pro Pro Val Pro Pro Arg Thr Thr Ser Lys 
    530                 535                 540                 


Pro Leu Ile Ser Val Thr Ala Gln Ser Ser Thr Glu Ser Thr Gln Asp 
545                 550                 555                 560 


Ala Tyr Gln Asp Ser Arg Ala Gln Arg Met Ser Pro Trp Pro Gln Asp 
                565                 570                 575     


Ser Arg Gly Leu Tyr Asn Ser Thr Asp Ser Leu Asp Ser Asn Lys Ala 
            580                 585                 590         


Met Asn Leu Ala Leu Glu Thr Ala Ala Ala Gln Arg His Leu Pro Glu 
        595                 600                 605             


Ser Gln Ser Ser Ser Val Arg Thr Ser Asp Lys Ala Ile Leu Val Ser 
    610                 615                 620                 


Lys Ala Glu Glu Leu Leu Lys Ser Arg Cys Ser Ser Ile Gly Ile Gln 
625                 630                 635                 640 


Asp Ser Glu Phe Pro Glu His Gln Pro Tyr Pro Arg Ser Asp Val Glu 
                645                 650                 655     


Thr Ala Thr Asp Ser Asp Thr Glu Ser Arg Gly Leu Arg Glu Tyr His 
            660                 665                 670         


Ser Val Gly Val Gln Val Glu Asp Glu Lys Arg His Gly Arg Phe Lys 
        675                 680                 685             


Arg Ser Asn Ser Val Thr Ala Ala Val Gln Ala Asp Leu Glu Leu Glu 
    690                 695                 700                 


Gly Phe Pro Gly His Ile Thr Thr Glu Asp Lys Gly Leu Gln Phe Gly 
705                 710                 715                 720 


Ser Ser Phe Gln Arg His Ser Glu Pro Ser Thr Pro Thr Gln Tyr Ser 
                725                 730                 735     


Ala Val Arg Thr Val Arg Thr Gln Gly Leu Phe Ser Tyr Arg Glu Asp 
            740                 745                 750         


Tyr Arg Thr Gln Val Asp Thr Ser Thr Leu Pro Pro Pro Asp Pro Trp 
        755                 760                 765             


Leu Glu Pro Ala Ile Asp Thr Val Glu Thr Gly Arg Met Ser Pro Cys 
    770                 775                 780                 


Arg Arg Asp Gly Ser Trp Phe Leu Lys Leu Leu His Ala Glu Thr Lys 
785                 790                 795                 800 


Arg Met Glu Gly Trp Cys Lys Glu Met Glu Arg Glu Ala Glu Glu Asn 
                805                 810                 815     


Asp Leu Ser Glu Glu Ile Leu Gly Lys Ile Arg Ser Ala Val Gly Ser 
            820                 825                 830         


Ala Gln Leu Leu Met Ser Gln Lys Phe Gln Gln Phe Tyr Trp Leu Cys 
        835                 840                 845             


Gln Gln Asn Met Asp Pro Ser Ala Met Pro Arg Pro Thr Ser Gln Asp 
    850                 855                 860                 


Leu Ala Gly Tyr Trp Asp Met Leu Gln Leu Ser Ile Glu Asp Val Ser 
865                 870                 875                 880 


Met Lys Phe Asp Glu Leu Gln Arg Leu Arg Leu Asn Asp Trp Lys Met 
                885                 890                 895     


Met Glu Ser Pro Glu Arg Lys Glu Glu Arg Lys Val Pro Pro Pro Ile 
            900                 905                 910         


Pro Lys Lys Pro Pro Lys Gly Lys Phe Pro Ile Thr Arg Glu Lys Ser 
        915                 920                 925             


Leu Asp Leu Pro Asp Arg Gln Arg Gln Glu Ala Arg Arg Arg Leu Met 
    930                 935                 940                 


Ala Ala Lys Arg Ala Ala Ser Phe Arg Gln Asn Ser Ala Ser Glu Arg 
945                 950                 955                 960 


Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln Thr Arg Leu 
                965                 970                 975 


<210>  3104
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLGAP3__Homo_sapiens__XP_011540181

<400>  3104

Met Arg Gly Tyr His Gly Asp Arg Gly Ser His Pro Arg Pro Ala Arg 
1               5                   10                  15      


Phe Ala Asp Gln Gln His Met Asp Val Gly Pro Ala Ala Arg Ala Pro 
            20                  25                  30          


Tyr Leu Leu Gly Ser Arg Glu Ala Phe Ser Thr Glu Pro Arg Phe Cys 
        35                  40                  45              


Ala Pro Arg Ala Gly Leu Gly His Ile Ser Pro Glu Gly Pro Leu Ser 
    50                  55                  60                  


Leu Ser Glu Gly Pro Ser Val Gly Pro Glu Gly Gly Pro Ala Gly Ala 
65                  70                  75                  80  


Gly Val Gly Gly Gly Ser Ser Thr Phe Pro Arg Met Tyr Pro Gly Gln 
                85                  90                  95      


Gly Pro Phe Asp Thr Cys Glu Asp Cys Val Gly His Pro Gln Gly Lys 
            100                 105                 110         


Gly Ala Pro Arg Leu Pro Pro Thr Leu Leu Asp Gln Phe Glu Lys Gln 
        115                 120                 125             


Leu Pro Val Gln Gln Asp Gly Phe His Thr Leu Pro Tyr Gln Arg Gly 
    130                 135                 140                 


Pro Ala Gly Ala Gly Pro Gly Pro Ala Pro Gly Thr Gly Thr Ala Pro 
145                 150                 155                 160 


Glu Pro Arg Ser Glu Ser Pro Ser Arg Ile Arg His Leu Val His Ser 
                165                 170                 175     


Val Gln Lys Leu Phe Ala Lys Ser His Ser Leu Glu Ala Pro Gly Lys 
            180                 185                 190         


Arg Asp Tyr Asn Gly Pro Lys Ala Glu Gly Arg Gly Gly Ser Gly Gly 
        195                 200                 205             


Asp Ser Tyr Pro Gly Pro Gly Ser Gly Gly Pro His Thr Ser His His 
    210                 215                 220                 


His His His His His His His His His His Gln Ser Arg His Gly Lys 
225                 230                 235                 240 


Arg Ser Lys Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Ala Lys 
                245                 250                 255     


Ser Thr Gly Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly 
            260                 265                 270         


Phe Leu Ala Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys 
        275                 280                 285             


Leu Glu Gly Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg 
    290                 295                 300                 


Ser Gly Gly Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met 
305                 310                 315                 320 


Ser Leu Asp Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met 
                325                 330                 335     


Val Ser Gln Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly 
            340                 345                 350         


Leu Leu Gly Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu 
        355                 360                 365             


Gln Val Pro Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp 
    370                 375                 380                 


Gly Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala 
385                 390                 395                 400 


Met Gly Asp Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser 
                405                 410                 415     


Pro Lys Ala Val Ala Arg Arg Phe Thr Thr Arg Arg Ser Ser Ser Val 
            420                 425                 430         


Asp Gln Ala Arg Ile Asn Cys Cys Val Pro Pro Arg Ile His Pro Arg 
        435                 440                 445             


Ser Ser Ile Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser 
    450                 455                 460                 


Asp Glu Leu Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly 
465                 470                 475                 480 


Glu Leu Glu Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe 
                485                 490                 495     


Arg Met Arg Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser 
            500                 505                 510         


Gln Asp Asp Asp Cys Leu Pro Leu Leu Ala Thr Pro Ala Ala Val Ser 
        515                 520                 525             


Gly Arg Pro Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile 
    530                 535                 540                 


Pro Pro Gly Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser 
545                 550                 555                 560 


Ser Thr Asp Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala 
                565                 570                 575     


Arg Arg Cys Ser Ser Ala Asp Gly Leu Asp Gly Pro Ala Met Gly Ala 
            580                 585                 590         


Arg Thr Leu Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro 
        595                 600                 605             


Pro Thr Leu Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser 
    610                 615                 620                 


Leu Ala Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu 
625                 630                 635                 640 


Thr Ile Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His 
                645                 650                 655     


Ser Ile Gly Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys 
            660                 665                 670         


Arg Ser Asn Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu 
        675                 680                 685             


Gly Leu Ala Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln 
    690                 695                 700                 


Phe Gly Arg Ser Phe Gln Arg His Ala Ser Glu Pro Gln Pro Gly Pro 
705                 710                 715                 720 


Arg Ala Pro Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln 
                725                 730                 735     


Trp Ala Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr 
            740                 745                 750         


Asp Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro Gly Pro Gly Ala 
        755                 760                 765             


Gly Arg Arg Asp Ser Trp Ile Glu Arg Gly Ser Arg Ser Leu Pro Asp 
    770                 775                 780                 


Ser Gly Arg Ala Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys 
785                 790                 795                 800 


Met Leu Arg Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met 
                805                 810                 815     


Glu Arg Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys 
            820                 825                 830         


Ile Arg Ser Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val 
        835                 840                 845             


Gln Gln Phe Phe Arg Leu Cys Gln Gln Ser Met Asp Pro Thr Ala Phe 
    850                 855                 860                 


Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln 
865                 870                 875                 880 


Leu Ser Ile Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu 
                885                 890                 895     


Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val 
            900                 905                 910         


Pro Pro Pro Ile Pro Lys Lys Pro Leu Arg Gly Arg Gly Val Pro Val 
        915                 920                 925             


Lys Glu Arg Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg 
    930                 935                 940                 


Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser 
945                 950                 955                 960 


Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln 
                965                 970                 975     


Thr Arg Leu 
            


<210>  3105
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLGAP5__Homo_sapiens__NP_001139487

<400>  3105

Met Ser Ser Ser His Phe Ala Ser Arg His Arg Lys Asp Ile Ser Thr 
1               5                   10                  15      


Glu Met Ile Arg Thr Lys Ile Ala His Arg Lys Ser Leu Ser Gln Lys 
            20                  25                  30          


Glu Asn Arg His Lys Glu Tyr Glu Arg Asn Arg His Phe Gly Leu Lys 
        35                  40                  45              


Asp Val Asn Ile Pro Thr Leu Glu Gly Arg Ile Leu Val Glu Leu Asp 
    50                  55                  60                  


Glu Thr Ser Gln Gly Leu Val Pro Glu Lys Thr Asn Val Lys Pro Arg 
65                  70                  75                  80  


Ala Met Lys Thr Ile Leu Gly Asp Gln Arg Lys Gln Met Leu Gln Lys 
                85                  90                  95      


Tyr Lys Glu Glu Lys Gln Leu Gln Lys Leu Lys Glu Gln Arg Glu Lys 
            100                 105                 110         


Ala Lys Arg Gly Ile Phe Lys Val Gly Arg Tyr Arg Pro Asp Met Pro 
        115                 120                 125             


Cys Phe Leu Leu Ser Asn Gln Asn Ala Val Lys Ala Glu Pro Lys Lys 
    130                 135                 140                 


Ala Ile Pro Ser Ser Val Arg Ile Thr Arg Ser Lys Ala Lys Asp Gln 
145                 150                 155                 160 


Met Glu Gln Thr Lys Ile Asp Asn Glu Ser Asp Val Arg Ala Ile Arg 
                165                 170                 175     


Pro Gly Pro Arg Gln Thr Ser Glu Lys Lys Val Ser Asp Lys Glu Lys 
            180                 185                 190         


Lys Val Val Gln Pro Val Met Pro Thr Ser Leu Arg Met Thr Arg Ser 
        195                 200                 205             


Ala Thr Gln Ala Ala Lys Gln Val Pro Arg Thr Val Ser Ser Thr Thr 
    210                 215                 220                 


Ala Arg Lys Pro Val Thr Arg Ala Ala Asn Glu Asn Glu Pro Glu Gly 
225                 230                 235                 240 


Lys Val Pro Ser Lys Gly Arg Pro Ala Lys Asn Val Glu Thr Lys Pro 
                245                 250                 255     


Asp Lys Gly Ile Ser Cys Lys Val Asp Ser Glu Glu Asn Thr Leu Asn 
            260                 265                 270         


Ser Gln Thr Asn Ala Thr Ser Gly Met Asn Pro Asp Gly Val Leu Ser 
        275                 280                 285             


Lys Met Glu Asn Leu Pro Glu Ile Asn Thr Ala Lys Ile Lys Gly Lys 
    290                 295                 300                 


Asn Ser Phe Ala Pro Lys Asp Phe Met Phe Gln Pro Leu Asp Gly Leu 
305                 310                 315                 320 


Lys Thr Tyr Gln Val Thr Pro Met Thr Pro Arg Ser Ala Asn Ala Phe 
                325                 330                 335     


Leu Thr Pro Ser Tyr Thr Trp Thr Pro Leu Lys Thr Glu Val Asp Glu 
            340                 345                 350         


Ser Gln Ala Thr Lys Glu Ile Leu Ala Gln Lys Cys Lys Thr Tyr Ser 
        355                 360                 365             


Thr Lys Thr Ile Gln Gln Asp Ser Asn Lys Leu Pro Cys Pro Leu Gly 
    370                 375                 380                 


Pro Leu Thr Val Trp His Glu Glu His Val Leu Asn Lys Asn Glu Ala 
385                 390                 395                 400 


Thr Thr Lys Asn Leu Asn Gly Leu Pro Ile Lys Glu Val Pro Ser Leu 
                405                 410                 415     


Glu Arg Asn Glu Gly Arg Ile Ala Gln Pro His His Gly Val Pro Tyr 
            420                 425                 430         


Phe Arg Asn Ile Leu Gln Ser Glu Thr Glu Lys Leu Thr Ser His Cys 
        435                 440                 445             


Phe Glu Trp Asp Arg Lys Leu Glu Leu Asp Ile Pro Asp Asp Ala Lys 
    450                 455                 460                 


Asp Leu Ile Arg Thr Ala Val Gly Gln Thr Arg Leu Leu Met Lys Glu 
465                 470                 475                 480 


Arg Phe Lys Gln Phe Glu Gly Leu Val Asp Asp Cys Glu Tyr Lys Arg 
                485                 490                 495     


Gly Ile Lys Glu Thr Thr Cys Thr Asp Leu Asp Gly Phe Trp Asp Met 
            500                 505                 510         


Val Ser Phe Gln Ile Glu Asp Val Ile His Lys Phe Asn Asn Leu Ile 
        515                 520                 525             


Lys Leu Glu Glu Ser Gly Trp Gln Val Asn Asn Asn Met Asn His Asn 
    530                 535                 540                 


Met Asn Lys Asn Val Phe Arg Lys Lys Val Val Ser Gly Ile Ala Ser 
545                 550                 555                 560 


Lys Pro Lys Gln Asp Asp Ala Gly Arg Ile Ala Ala Arg Asn Arg Leu 
                565                 570                 575     


Ala Ala Ile Lys Asn Ala Met Arg Glu Arg Ile Arg Gln Glu Glu Cys 
            580                 585                 590         


Ala Glu Thr Ala Val Ser Val Ile Pro Lys Glu Val Asp Lys Ile Val 
        595                 600                 605             


Phe Asp Ala Gly Phe Phe Arg Val Glu Ser Pro Val Lys Leu Phe Ser 
    610                 615                 620                 


Gly Leu Ser Val Ser Ser Glu Gly Pro Ser Gln Arg Leu Gly Thr Pro 
625                 630                 635                 640 


Lys Ser Val Asn Lys Ala Val Ser Gln Ser Arg Asn Glu Met Gly Ile 
                645                 650                 655     


Pro Gln Gln Thr Thr Ser Pro Glu Asn Ala Gly Pro Gln Asn Thr Lys 
            660                 665                 670         


Ser Glu His Val Lys Lys Thr Leu Phe Leu Ser Ile Pro Glu Ser Arg 
        675                 680                 685             


Ser Ser Ile Glu Asp Ala Gln Cys Pro Gly Leu Pro Asp Leu Ile Glu 
    690                 695                 700                 


Glu Asn His Val Val Asn Lys Thr Asp Leu Lys Val Asp Cys Leu Ser 
705                 710                 715                 720 


Ser Glu Arg Met Ser Leu Pro Leu Leu Ala Gly Gly Val Ala Asp Asp 
                725                 730                 735     


Ile Asn Thr Asn Lys Lys Glu Gly Ile Ser Asp Val Val Glu Gly Met 
            740                 745                 750         


Glu Leu Asn Ser Ser Ile Thr Ser Gln Asp Val Leu Met Ser Ser Pro 
        755                 760                 765             


Glu Lys Asn Thr Ala Ser Gln Asn Ser Ile Leu Glu Glu Gly Glu Thr 
    770                 775                 780                 


Lys Ile Ser Gln Ser Glu Leu Phe Asp Asn Lys Ser Leu Thr Thr Glu 
785                 790                 795                 800 


Cys His Leu Leu Asp Ser Val Gly Ser Cys Tyr Val Ala Arg Ala Gly 
                805                 810                 815     


Leu Glu Val Leu Gly Ser Ser Asp Pro Thr Thr Ser Ala Ser Arg Val 
            820                 825                 830         


Ala Gly Thr Thr Ala Arg Ser Lys Leu Gln 
        835                 840         


<210>  3106
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLK1__Homo_sapiens__NP_003827

<400>  3106

Met Thr Ala Thr Glu Ala Leu Leu Arg Val Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gly His Ser Thr Tyr Gly Ala Glu Cys Phe Pro Ala Cys Asn Pro 
            20                  25                  30          


Gln Asn Gly Phe Cys Glu Asp Asp Asn Val Cys Arg Cys Gln Pro Gly 
        35                  40                  45              


Trp Gln Gly Pro Leu Cys Asp Gln Cys Val Thr Ser Pro Gly Cys Leu 
    50                  55                  60                  


His Gly Leu Cys Gly Glu Pro Gly Gln Cys Ile Cys Thr Asp Gly Trp 
65                  70                  75                  80  


Asp Gly Glu Leu Cys Asp Arg Asp Val Arg Ala Cys Ser Ser Ala Pro 
                85                  90                  95      


Cys Ala Asn Asn Gly Thr Cys Val Ser Leu Asp Asp Gly Leu Tyr Glu 
            100                 105                 110         


Cys Ser Cys Ala Pro Gly Tyr Ser Gly Lys Asp Cys Gln Lys Lys Asp 
        115                 120                 125             


Gly Pro Cys Val Ile Asn Gly Ser Pro Cys Gln His Gly Gly Thr Cys 
    130                 135                 140                 


Val Asp Asp Glu Gly Arg Ala Ser His Ala Ser Cys Leu Cys Pro Pro 
145                 150                 155                 160 


Gly Phe Ser Gly Asn Phe Cys Glu Ile Val Ala Asn Ser Cys Thr Pro 
                165                 170                 175     


Asn Pro Cys Glu Asn Asp Gly Val Cys Thr Asp Ile Gly Gly Asp Phe 
            180                 185                 190         


Arg Cys Arg Cys Pro Ala Gly Phe Ile Asp Lys Thr Cys Ser Arg Pro 
        195                 200                 205             


Val Thr Asn Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Thr Cys Leu 
    210                 215                 220                 


Gln His Thr Gln Val Ser Tyr Glu Cys Leu Cys Lys Pro Glu Phe Thr 
225                 230                 235                 240 


Gly Leu Thr Cys Val Lys Lys Arg Ala Leu Ser Pro Gln Gln Val Thr 
                245                 250                 255     


Arg Leu Pro Ser Gly Tyr Gly Leu Ala Tyr Arg Leu Thr Pro Gly Val 
            260                 265                 270         


His Glu Leu Pro Val Gln Gln Pro Glu His Arg Ile Leu Lys Val Ser 
        275                 280                 285             


Met Lys Glu Leu Asn Lys Lys Thr Pro Leu Leu Thr Glu Gly Gln Ala 
    290                 295                 300                 


Ile Cys Phe Thr Ile Leu Gly Val Leu Thr Ser Leu Val Val Leu Gly 
305                 310                 315                 320 


Thr Val Gly Ile Val Phe Leu Asn Lys Cys Glu Thr Trp Val Ser Asn 
                325                 330                 335     


Leu Arg Tyr Asn His Met Leu Arg Lys Lys Lys Asn Leu Leu Leu Gln 
            340                 345                 350         


Tyr Asn Ser Gly Glu Asp Leu Ala Val Asn Ile Ile Phe Pro Glu Lys 
        355                 360                 365             


Ile Asp Met Thr Thr Phe Ser Lys Glu Ala Gly Asp Glu Glu Ile 
    370                 375                 380             


<210>  3107
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL1__Homo_sapiens__XP_011534060

<400>  3107

Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      


Cys Gln Val Trp Ser Ser Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 
            20                  25                  30          


Val Asn Lys Lys Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 
        35                  40                  45              


Ala Gly Pro Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly 
65                  70                  75                  80  


Ser Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro Asp 
                85                  90                  95      


Gly Gly Gly Ala Asp Ser Ala Phe Ser Asn Pro Ile Arg Phe Pro Phe 
            100                 105                 110         


Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 
        115                 120                 125             


Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile 
    130                 135                 140                 


Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu Trp Ser 
145                 150                 155                 160 


Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys Tyr Ser Tyr Arg 
                165                 170                 175     


Phe Val Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys 
            180                 185                 190         


Arg Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Glu Arg Gly 
        195                 200                 205             


Glu Lys Val Cys Asn Pro Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 
    210                 215                 220                 


Ile Cys Leu Pro Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 
225                 230                 235                 240 


Gly Glu Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 
                245                 250                 255     


Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 
            260                 265                 270         


Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp 
        275                 280                 285             


Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn Gly Ala Thr Cys 
    290                 295                 300                 


Thr Asn Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr 
305                 310                 315                 320 


Thr Gly Ala Thr Cys Glu Leu Gly Ile Asp Glu Cys Asp Pro Ser Pro 
                325                 330                 335     


Cys Lys Asn Gly Gly Ser Cys Thr Asp Leu Glu Asn Ser Tyr Ser Cys 
            340                 345                 350         


Thr Cys Pro Pro Gly Phe Tyr Gly Lys Ile Cys Glu Leu Ser Ala Met 
        355                 360                 365             


Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Arg Cys Ser Asp Ser 
    370                 375                 380                 


Pro Asp Gly Gly Tyr Ser Cys Arg Cys Pro Val Gly Tyr Ser Gly Phe 
385                 390                 395                 400 


Asn Cys Glu Lys Lys Ile Asp Tyr Cys Ser Ser Ser Pro Cys Ser Asn 
                405                 410                 415     


Gly Ala Lys Cys Val Asp Leu Gly Asp Ala Tyr Leu Cys Arg Cys Gln 
            420                 425                 430         


Ala Gly Phe Ser Gly Arg His Cys Asp Asp Asn Val Asp Asp Cys Ala 
        435                 440                 445             


Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Gly Val Asn Asp 
    450                 455                 460                 


Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Arg Asn Cys Ser Ala 
465                 470                 475                 480 


Pro Val Ser Arg Cys Glu His Ala Pro Cys His Asn Gly Ala Thr Cys 
                485                 490                 495     


His Glu Arg Gly His Arg Tyr Val Cys Glu Cys Ala Arg Gly Tyr Gly 
            500                 505                 510         


Gly Pro Asn Cys Gln Phe Leu Leu Pro Glu Leu Pro Pro Gly Pro Ala 
        515                 520                 525             


Val Val Asp Leu Thr Glu Lys Leu Glu Gly Gln Gly Gly Pro Phe Pro 
    530                 535                 540                 


Trp Val Ala Val Cys Ala Gly Val Ile Leu Val Leu Met Leu Leu Leu 
545                 550                 555                 560 


Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Arg Leu Gln Lys His 
                565                 570                 575     


Arg Pro Pro Ala Asp Pro Cys Arg Gly Glu Thr Glu Thr Met Asn Asn 
            580                 585                 590         


Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 
        595                 600                 605             


Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp 
    610                 615                 620                 


His Ser Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro Ala Val Asp 
625                 630                 635                 640 


Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val Arg Asp 
                645                 650                 655     


Ala His Ser Lys Arg Asp Thr Lys Cys Gln Pro Gln Gly Ser Ser Gly 
            660                 665                 670         


Glu Glu Lys Gly Thr Pro Thr Thr Leu Arg Gly Gly Glu Ala Ser Glu 
        675                 680                 685             


Arg Lys Arg Pro Asp Ser Gly Cys Ser Thr Ser Lys Asp Thr Lys Tyr 
    690                 695                 700                 


Gln Ser Val Tyr Val Ile Ser Glu Glu Lys Asp Glu Cys Val Ile Ala 
705                 710                 715                 720 


Thr Glu Val 
            


<210>  3108
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL3__Homo_sapiens__NP_058637

<400>  3108

Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      


Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Ala Gly Val Phe Glu Leu 
            20                  25                  30          


Gln Ile His Ser Phe Gly Pro Gly Pro Gly Pro Gly Ala Pro Arg Ser 
        35                  40                  45              


Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu Phe Phe Arg Val Cys Leu 
    50                  55                  60                  


Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu Ser Pro Cys Ala Leu Gly 
65                  70                  75                  80  


Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr Thr Glu Gln Pro Gly Ala 
                85                  90                  95      


Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly Leu Leu Gln Val Pro Phe 
            100                 105                 110         


Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe Ile Ile Glu Thr Trp Arg 
        115                 120                 125             


Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro Ala Trp Ser Leu Leu Ala 
    130                 135                 140                 


Arg Val Ala Gly Arg Arg Arg Leu Ala Ala Gly Gly Pro Trp Ala Arg 
145                 150                 155                 160 


Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu Arg Phe Ser Tyr Arg Ala 
                165                 170                 175     


Arg Cys Glu Pro Pro Ala Val Gly Thr Ala Cys Thr Arg Leu Cys Arg 
            180                 185                 190         


Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro Gly Leu Arg Pro Cys Ala 
        195                 200                 205             


Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu Val Cys Arg Ala Gly Cys 
    210                 215                 220                 


Ser Pro Glu His Gly Phe Cys Glu Gln Pro Gly Glu Cys Arg Cys Leu 
225                 230                 235                 240 


Glu Gly Trp Thr Gly Pro Leu Cys Thr Val Pro Val Ser Thr Ser Ser 
                245                 250                 255     


Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala Thr Thr Gly Cys Leu Val 
            260                 265                 270         


Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser 
        275                 280                 285             


Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe 
    290                 295                 300                 


Tyr Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro 
305                 310                 315                 320 


Cys Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala 
                325                 330                 335     


Tyr Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu Lys 
            340                 345                 350         


Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
        355                 360                 365             


Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
    370                 375                 380                 


Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 
385                 390                 395                 400 


Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 
                405                 410                 415     


Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg Glu Arg Ala Asp Pro 
            420                 425                 430         


Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys Tyr Ala His Phe 
        435                 440                 445             


Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met Gly Ala Arg Cys 
    450                 455                 460                 


Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro 
465                 470                 475                 480 


Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu Leu Pro Pro Ala 
                485                 490                 495     


Leu Gly Leu Leu Val Ala Ala Gly Val Ala Gly Ala Ala Leu Leu Leu 
            500                 505                 510         


Val His Val Arg Arg Arg Gly His Ser Gln Asp Ala Gly Ser Arg Leu 
        515                 520                 525             


Leu Ala Gly Thr Pro Glu Pro Ser Val His Ala Leu Pro Asp Ala Leu 
    530                 535                 540                 


Asn Asn Leu Arg Thr Gln Glu Gly Ser Gly Asp Gly Pro Ser Ser Ser 
545                 550                 555                 560 


Val Asp Trp Asn Arg Pro Glu Asp Val Asp Pro Gln Gly Ile Tyr Val 
                565                 570                 575     


Ile Ser Ala Pro Ser Ile Tyr Ala Arg Glu Val Ala Thr Pro Leu Phe 
            580                 585                 590         


Pro Pro Leu His Thr Gly Arg Ala Gly Gln Arg Gln His Leu Leu Phe 
        595                 600                 605             


Pro Tyr Pro Ser Ser Ile Leu Ser Val Lys 
    610                 615             


<210>  3109
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL4__Homo_sapiens__NP_061947

<400>  3109

Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      


Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Ser Gly Val Phe Gln Leu 
            20                  25                  30          


Gln Leu Gln Glu Phe Ile Asn Glu Arg Gly Val Leu Ala Ser Gly Arg 
        35                  40                  45              


Pro Cys Glu Pro Gly Cys Arg Thr Phe Phe Arg Val Cys Leu Lys His 
    50                  55                  60                  


Phe Gln Ala Val Val Ser Pro Gly Pro Cys Thr Phe Gly Thr Val Ser 
65                  70                  75                  80  


Thr Pro Val Leu Gly Thr Asn Ser Phe Ala Val Arg Asp Asp Ser Ser 
                85                  90                  95      


Gly Gly Gly Arg Asn Pro Leu Gln Leu Pro Phe Asn Phe Thr Trp Pro 
            100                 105                 110         


Gly Thr Phe Ser Leu Ile Ile Glu Ala Trp His Ala Pro Gly Asp Asp 
        115                 120                 125             


Leu Arg Pro Glu Ala Leu Pro Pro Asp Ala Leu Ile Ser Lys Ile Ala 
    130                 135                 140                 


Ile Gln Gly Ser Leu Ala Val Gly Gln Asn Trp Leu Leu Asp Glu Gln 
145                 150                 155                 160 


Thr Ser Thr Leu Thr Arg Leu Arg Tyr Ser Tyr Arg Val Ile Cys Ser 
                165                 170                 175     


Asp Asn Tyr Tyr Gly Asp Asn Cys Ser Arg Leu Cys Lys Lys Arg Asn 
            180                 185                 190         


Asp His Phe Gly His Tyr Val Cys Gln Pro Asp Gly Asn Leu Ser Cys 
        195                 200                 205             


Leu Pro Gly Trp Thr Gly Glu Tyr Cys Gln Gln Pro Ile Cys Leu Ser 
    210                 215                 220                 


Gly Cys His Glu Gln Asn Gly Tyr Cys Ser Lys Pro Ala Glu Cys Leu 
225                 230                 235                 240 


Cys Arg Pro Gly Trp Gln Gly Arg Leu Cys Asn Glu Cys Ile Pro His 
                245                 250                 255     


Asn Gly Cys Arg His Gly Thr Cys Ser Thr Pro Trp Gln Cys Thr Cys 
            260                 265                 270         


Asp Glu Gly Trp Gly Gly Leu Phe Cys Asp Gln Asp Leu Asn Tyr Cys 
        275                 280                 285             


Thr His His Ser Pro Cys Lys Asn Gly Ala Thr Cys Ser Asn Ser Gly 
    290                 295                 300                 


Gln Arg Ser Tyr Thr Cys Thr Cys Arg Pro Gly Tyr Thr Gly Val Asp 
305                 310                 315                 320 


Cys Glu Leu Glu Leu Ser Glu Cys Asp Ser Asn Pro Cys Arg Asn Gly 
                325                 330                 335     


Gly Ser Cys Lys Asp Gln Glu Asp Gly Tyr His Cys Leu Cys Pro Pro 
            340                 345                 350         


Gly Tyr Tyr Gly Leu His Cys Glu His Ser Thr Leu Ser Cys Ala Asp 
        355                 360                 365             


Ser Pro Cys Phe Asn Gly Gly Ser Cys Arg Glu Arg Asn Gln Gly Ala 
    370                 375                 380                 


Asn Tyr Ala Cys Glu Cys Pro Pro Asn Phe Thr Gly Ser Asn Cys Glu 
385                 390                 395                 400 


Lys Lys Val Asp Arg Cys Thr Ser Asn Pro Cys Ala Asn Gly Gly Gln 
                405                 410                 415     


Cys Leu Asn Arg Gly Pro Ser Arg Met Cys Arg Cys Arg Pro Gly Phe 
            420                 425                 430         


Thr Gly Thr Tyr Cys Glu Leu His Val Ser Asp Cys Ala Arg Asn Pro 
        435                 440                 445             


Cys Ala His Gly Gly Thr Cys His Asp Leu Glu Asn Gly Leu Met Cys 
    450                 455                 460                 


Thr Cys Pro Ala Gly Phe Ser Gly Arg Arg Cys Glu Val Arg Thr Ser 
465                 470                 475                 480 


Ile Asp Ala Cys Ala Ser Ser Pro Cys Phe Asn Arg Ala Thr Cys Tyr 
                485                 490                 495     


Thr Asp Leu Ser Thr Asp Thr Phe Val Cys Asn Cys Pro Tyr Gly Phe 
            500                 505                 510         


Val Gly Ser Arg Cys Glu Phe Pro Val Gly Leu Pro Pro Ser Phe Pro 
        515                 520                 525             


Trp Val Ala Val Ser Leu Gly Val Gly Leu Ala Val Leu Leu Val Leu 
    530                 535                 540                 


Leu Gly Met Val Ala Val Ala Val Arg Gln Leu Arg Leu Arg Arg Pro 
545                 550                 555                 560 


Asp Asp Gly Ser Arg Glu Ala Met Asn Asn Leu Ser Asp Phe Gln Lys 
                565                 570                 575     


Asp Asn Leu Ile Pro Ala Ala Gln Leu Lys Asn Thr Asn Gln Lys Lys 
            580                 585                 590         


Glu Leu Glu Val Asp Cys Gly Leu Asp Lys Ser Asn Cys Gly Lys Gln 
        595                 600                 605             


Gln Asn His Thr Leu Asp Tyr Asn Leu Ala Pro Gly Pro Leu Gly Arg 
    610                 615                 620                 


Gly Thr Met Pro Gly Lys Phe Pro His Ser Asp Lys Ser Leu Gly Glu 
625                 630                 635                 640 


Lys Ala Pro Leu Arg Leu His Ser Glu Lys Pro Glu Cys Arg Ile Ser 
                645                 650                 655     


Ala Ile Cys Ser Pro Arg Asp Ser Met Tyr Gln Ser Val Cys Leu Ile 
            660                 665                 670         


Ser Glu Glu Arg Asn Glu Cys Val Ile Ala Thr Glu Val 
        675                 680                 685 


<210>  3110
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLST__Homo_sapiens__NP_001924

<400>  3110

Met Leu Ser Arg Ser Arg Cys Val Ser Arg Ala Phe Ser Arg Ser Leu 
1               5                   10                  15      


Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg Arg Ser Leu Pro 
            20                  25                  30          


Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asn Ser Arg Lys Val 
        35                  40                  45              


Val Ile Asn Asn Ser Val Phe Ser Val Arg Phe Phe Arg Thr Thr Ala 
    50                  55                  60                  


Val Cys Lys Asp Asp Leu Val Thr Val Lys Thr Pro Ala Phe Ala Glu 
65                  70                  75                  80  


Ser Val Thr Glu Gly Asp Val Arg Trp Glu Lys Ala Val Gly Asp Thr 
                85                  90                  95      


Val Ala Glu Asp Glu Val Val Cys Glu Ile Glu Thr Asp Lys Thr Ser 
            100                 105                 110         


Val Gln Val Pro Ser Pro Ala Asn Gly Val Ile Glu Ala Leu Leu Val 
        115                 120                 125             


Pro Asp Gly Gly Lys Val Glu Gly Gly Thr Pro Leu Phe Thr Leu Arg 
    130                 135                 140                 


Lys Thr Gly Ala Ala Pro Ala Lys Ala Lys Pro Ala Glu Ala Pro Ala 
145                 150                 155                 160 


Ala Ala Ala Pro Lys Ala Glu Pro Thr Ala Ala Ala Val Pro Pro Pro 
                165                 170                 175     


Ala Ala Pro Ile Pro Thr Gln Met Pro Pro Val Pro Ser Pro Ser Gln 
            180                 185                 190         


Pro Pro Ser Gly Lys Pro Val Ser Ala Val Lys Pro Thr Val Ala Pro 
        195                 200                 205             


Pro Leu Ala Glu Pro Gly Ala Gly Lys Gly Leu Arg Ser Glu His Arg 
    210                 215                 220                 


Glu Lys Met Asn Arg Met Arg Gln Arg Ile Ala Gln Arg Leu Lys Glu 
225                 230                 235                 240 


Ala Gln Asn Thr Cys Ala Met Leu Thr Thr Phe Asn Glu Ile Asp Met 
                245                 250                 255     


Ser Asn Ile Gln Glu Met Arg Ala Arg His Lys Glu Ala Phe Leu Lys 
            260                 265                 270         


Lys His Asn Leu Lys Leu Gly Phe Met Ser Ala Phe Val Lys Ala Ser 
        275                 280                 285             


Ala Phe Ala Leu Gln Glu Gln Pro Val Val Asn Ala Val Ile Asp Asp 
    290                 295                 300                 


Thr Thr Lys Glu Val Val Tyr Arg Asp Tyr Ile Asp Ile Ser Val Ala 
305                 310                 315                 320 


Val Ala Thr Pro Arg Gly Leu Val Val Pro Val Ile Arg Asn Val Glu 
                325                 330                 335     


Ala Met Asn Phe Ala Asp Ile Glu Arg Thr Ile Thr Glu Leu Gly Glu 
            340                 345                 350         


Lys Ala Arg Lys Asn Glu Leu Ala Ile Glu Asp Met Asp Gly Gly Thr 
        355                 360                 365             


Phe Thr Ile Ser Asn Gly Gly Val Phe Gly Ser Leu Phe Gly Thr Pro 
    370                 375                 380                 


Ile Ile Asn Pro Pro Gln Ser Ala Ile Leu Gly Met His Gly Ile Phe 
385                 390                 395                 400 


Asp Arg Pro Val Ala Ile Gly Gly Lys Val Glu Val Arg Pro Met Met 
                405                 410                 415     


Tyr Val Ala Leu Thr Tyr Asp His Arg Leu Ile Asp Gly Arg Glu Ala 
            420                 425                 430         


Val Thr Phe Leu Arg Lys Ile Lys Ala Ala Val Glu Asp Pro Arg Val 
        435                 440                 445             


Leu Leu Leu Asp Leu 
    450             


<210>  3111
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLX1__Homo_sapiens__NP_001033582

<400>  3111

Met Thr Met Thr Thr Met Pro Glu Ser Leu Asn Ser Pro Val Ser Gly 
1               5                   10                  15      


Lys Ala Val Phe Met Glu Phe Gly Pro Pro Asn Gln Gln Met Ser Pro 
            20                  25                  30          


Ser Pro Met Ser His Gly His Tyr Ser Met His Cys Leu His Ser Ala 
        35                  40                  45              


Gly His Ser Gln Pro Asp Gly Ala Tyr Ser Ser Ala Ser Ser Phe Ser 
    50                  55                  60                  


Arg Pro Leu Gly Tyr Pro Tyr Val Asn Ser Val Ser Ser His Ala Ser 
65                  70                  75                  80  


Ser Pro Tyr Ile Ser Ser Val Gln Ser Tyr Pro Gly Ser Ala Ser Leu 
                85                  90                  95      


Ala Gln Ser Arg Leu Glu Asp Pro Gly Gln Asp Leu Val Pro Lys Gln 
            100                 105                 110         


Ala Ile Gln Val Gln Glu Ala Asp Glu Ala Gly Trp Gly Gly Ser Gly 
        115                 120                 125             


Gly 
    


<210>  3112
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLX2__Homo_sapiens__NP_004396

<400>  3112

Met Thr Gly Val Phe Asp Ser Leu Val Ala Asp Met His Ser Thr Gln 
1               5                   10                  15      


Ile Ala Ala Ser Ser Thr Tyr His Gln His Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Gly Gly Ala Gly Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Leu His 
        35                  40                  45              


Lys Pro Gln Glu Ser Pro Thr Leu Pro Val Ser Thr Ala Thr Asp Ser 
    50                  55                  60                  


Ser Tyr Tyr Thr Asn Gln Gln His Pro Ala Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Pro Tyr Ala His Met Gly Ser Tyr Gln Tyr Gln Ala Ser Gly 
                85                  90                  95      


Leu Asn Asn Val Pro Tyr Ser Ala Lys Ser Ser Tyr Asp Leu Gly Tyr 
            100                 105                 110         


Thr Ala Ala Tyr Thr Ser Tyr Ala Pro Tyr Gly Thr Ser Ser Ser Pro 
        115                 120                 125             


Ala Asn Asn Glu Pro Glu Lys Glu Asp Leu Glu Pro Glu Ile Arg Ile 
    130                 135                 140                 


Val Asn Gly Lys Pro Lys Lys Val Arg Lys Pro Arg Thr Ile Tyr Ser 
145                 150                 155                 160 


Ser Phe Gln Leu Ala Ala Leu Gln Arg Arg Phe Gln Lys Thr Gln Tyr 
                165                 170                 175     


Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu Gly Leu Thr 
            180                 185                 190         


Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ser Lys Phe Lys 
        195                 200                 205             


Lys Met Trp Lys Ser Gly Glu Ile Pro Ser Glu Gln His Pro Gly Ala 
    210                 215                 220                 


Ser Ala Ser Pro Pro Cys Ala Ser Pro Pro Val Ser Ala Pro Ala Ser 
225                 230                 235                 240 


Trp Asp Phe Gly Val Pro Gln Arg Met Ala Gly Gly Gly Gly Pro Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Ala Gly Ser Ser Gly Ser Ser Pro Ser Ser Ala 
            260                 265                 270         


Ala Ser Ala Phe Leu Gly Asn Tyr Pro Trp Tyr His Gln Thr Ser Gly 
        275                 280                 285             


Ser Ala Ser His Leu Gln Ala Thr Ala Pro Leu Leu His Pro Thr Gln 
    290                 295                 300                 


Thr Pro Gln Pro His His His His His His His Gly Gly Gly Gly Ala 
305                 310                 315                 320 


Pro Val Ser Ala Gly Thr Ile Phe 
                325             


<210>  3113
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLX3__Homo_sapiens__NP_005211

<400>  3113

Met Ser Gly Ser Phe Asp Arg Lys Leu Ser Ser Ile Leu Thr Asp Ile 
1               5                   10                  15      


Ser Ser Ser Leu Ser Cys His Ala Gly Ser Lys Asp Ser Pro Thr Leu 
            20                  25                  30          


Pro Glu Ser Ser Val Thr Asp Leu Gly Tyr Tyr Ser Ala Pro Gln His 
        35                  40                  45              


Asp Tyr Tyr Ser Gly Gln Pro Tyr Gly Gln Thr Val Asn Pro Tyr Thr 
    50                  55                  60                  


Tyr His His Gln Phe Asn Leu Asn Gly Leu Ala Gly Thr Gly Ala Tyr 
65                  70                  75                  80  


Ser Pro Lys Ser Glu Tyr Thr Tyr Gly Ala Ser Tyr Arg Gln Tyr Gly 
                85                  90                  95      


Ala Tyr Arg Glu Gln Pro Leu Pro Ala Gln Asp Pro Val Ser Val Lys 
            100                 105                 110         


Glu Glu Pro Glu Ala Glu Val Arg Met Val Asn Gly Lys Pro Lys Lys 
        115                 120                 125             


Val Arg Lys Pro Arg Thr Ile Tyr Ser Ser Tyr Gln Leu Ala Ala Leu 
    130                 135                 140                 


Gln Arg Arg Phe Gln Lys Ala Gln Tyr Leu Ala Leu Pro Glu Arg Ala 
145                 150                 155                 160 


Glu Leu Ala Ala Gln Leu Gly Leu Thr Gln Thr Gln Val Lys Ile Trp 
                165                 170                 175     


Phe Gln Asn Arg Arg Ser Lys Phe Lys Lys Leu Tyr Lys Asn Gly Glu 
            180                 185                 190         


Val Pro Leu Glu His Ser Pro Asn Asn Ser Asp Ser Met Ala Cys Asn 
        195                 200                 205             


Ser Pro Pro Ser Pro Ala Leu Trp Asp Thr Ser Ser His Ser Thr Pro 
    210                 215                 220                 


Ala Pro Ala Arg Ser Gln Leu Pro Pro Pro Leu Pro Tyr Ser Ala Ser 
225                 230                 235                 240 


Pro Ser Tyr Leu Asp Asp Pro Thr Asn Ser Trp Tyr His Ala Gln Asn 
                245                 250                 255     


Leu Ser Gly Pro His Leu Gln Gln Gln Pro Pro Gln Pro Ala Thr Leu 
            260                 265                 270         


His His Ala Ser Pro Gly Pro Pro Pro Asn Pro Gly Ala Val Tyr 
        275                 280                 285         


<210>  3114
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLX4__Homo_sapiens__NP_612138

<400>  3114

Met Thr Ser Leu Pro Cys Pro Leu Pro Gly Arg Asp Ala Ser Lys Ala 
1               5                   10                  15      


Val Phe Pro Asp Leu Ala Pro Val Pro Ser Val Ala Ala Ala Tyr Pro 
            20                  25                  30          


Leu Gly Leu Ser Pro Thr Thr Ala Ala Ser Pro Asn Leu Ser Tyr Ser 
        35                  40                  45              


Arg Pro Tyr Gly His Leu Leu Ser Tyr Pro Tyr Thr Glu Pro Ala Asn 
    50                  55                  60                  


Pro Gly Asp Ser Tyr Leu Ser Cys Gln Gln Pro Ala Ala Leu Ser Gln 
65                  70                  75                  80  


Pro Leu Cys Gly Pro Ala Glu His Pro Gln Glu Leu Glu Ala Asp Ser 
                85                  90                  95      


Glu Lys Pro Arg Leu Ser Pro Glu Pro Ser Glu Arg Arg Pro Gln Ala 
            100                 105                 110         


Pro Ala Lys Lys Leu Arg Lys Pro Arg Thr Ile Tyr Ser Ser Leu Gln 
        115                 120                 125             


Leu Gln His Leu Asn Gln Arg Phe Gln His Thr Gln Tyr Leu Ala Leu 
    130                 135                 140                 


Pro Glu Arg Ala Gln Leu Ala Ala Gln Leu Gly Leu Thr Gln Thr Gln 
145                 150                 155                 160 


Val Lys Ile Trp Phe Gln Asn Lys Arg Ser Lys Tyr Lys Lys Leu Leu 
                165                 170                 175     


Lys Gln Asn Ser Gly Gly Gln Glu Gly Asp Phe Pro Gly Arg Thr Phe 
            180                 185                 190         


Ser Val Ser Pro Cys Ser Pro Pro Leu Pro Ser Leu Trp Asp Leu Pro 
        195                 200                 205             


Lys Ala Gly Thr Leu Pro Thr Ser Gly Tyr Gly Asn Ser Phe Gly Ala 
    210                 215                 220                 


Trp Tyr Gln His His Ser Ser Asp Val Leu Ala Ser Pro Gln Met Met 
225                 230                 235                 240 


<210>  3115
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLX5__Homo_sapiens__NP_005212

<400>  3115

Met Thr Gly Val Phe Asp Arg Arg Val Pro Ser Ile Arg Ser Gly Asp 
1               5                   10                  15      


Phe Gln Ala Pro Phe Gln Thr Ser Ala Ala Met His His Pro Ser Gln 
            20                  25                  30          


Glu Ser Pro Thr Leu Pro Glu Ser Ser Ala Thr Asp Ser Asp Tyr Tyr 
        35                  40                  45              


Ser Pro Thr Gly Gly Ala Pro His Gly Tyr Cys Ser Pro Thr Ser Ala 
    50                  55                  60                  


Ser Tyr Gly Lys Ala Leu Asn Pro Tyr Gln Tyr Gln Tyr His Gly Val 
65                  70                  75                  80  


Asn Gly Ser Ala Gly Ser Tyr Pro Ala Lys Ala Tyr Ala Asp Tyr Ser 
                85                  90                  95      


Tyr Ala Ser Ser Tyr His Gln Tyr Gly Gly Ala Tyr Asn Arg Val Pro 
            100                 105                 110         


Ser Ala Thr Asn Gln Pro Glu Lys Glu Val Thr Glu Pro Glu Val Arg 
        115                 120                 125             


Met Val Asn Gly Lys Pro Lys Lys Val Arg Lys Pro Arg Thr Ile Tyr 
    130                 135                 140                 


Ser Ser Phe Gln Leu Ala Ala Leu Gln Arg Arg Phe Gln Lys Thr Gln 
145                 150                 155                 160 


Tyr Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu Gly Leu 
                165                 170                 175     


Thr Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Lys Arg Ser Lys Ile 
            180                 185                 190         


Lys Lys Ile Met Lys Asn Gly Glu Met Pro Pro Glu His Ser Pro Ser 
        195                 200                 205             


Ser Ser Asp Pro Met Ala Cys Asn Ser Pro Gln Ser Pro Ala Val Trp 
    210                 215                 220                 


Glu Pro Gln Gly Ser Ser Arg Ser Leu Ser His His Pro His Ala His 
225                 230                 235                 240 


Pro Pro Thr Ser Asn Gln Ser Pro Ala Ser Ser Tyr Leu Glu Asn Ser 
                245                 250                 255     


Ala Ser Trp Tyr Thr Ser Ala Ala Ser Ser Ile Asn Ser His Leu Pro 
            260                 265                 270         


Pro Pro Gly Ser Leu Gln His Pro Leu Ala Leu Ala Ser Gly Thr Leu 
        275                 280                 285             


Tyr 
    


<210>  3116
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLX6__Homo_sapiens__NP_005213

<400>  3116

Met Met Thr Met Thr Thr Met Ala Asp Gly Leu Glu Gly Gln Asp Ser 
1               5                   10                  15      


Ser Lys Ser Ala Phe Met Glu Phe Gly Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Gln Pro His Ser Gln Gln Ser Ser Pro Ala Met 
    50                  55                  60                  


Ala Gly Ala His Tyr Pro Leu His Cys Leu His Ser Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Gly Ser His His His His His His Gln His His His His 
                85                  90                  95      


Gly Ser Pro Tyr Ala Ser Gly Gly Gly Asn Ser Tyr Asn His Arg Ser 
            100                 105                 110         


Leu Ala Ala Tyr Pro Tyr Met Ser His Ser Gln His Ser Pro Tyr Leu 
        115                 120                 125             


Gln Ser Tyr His Asn Ser Ser Ala Ala Ala Gln Thr Arg Gly Asp Asp 
    130                 135                 140                 


Thr Asp Gln Gln Lys Thr Thr Val Ile Glu Asn Gly Glu Ile Arg Phe 
145                 150                 155                 160 


Asn Gly Lys Gly Lys Lys Ile Arg Lys Pro Arg Thr Ile Tyr Ser Ser 
                165                 170                 175     


Leu Gln Leu Gln Ala Leu Asn His Arg Phe Gln Gln Thr Gln Tyr Leu 
            180                 185                 190         


Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu Gly Leu Thr Gln 
        195                 200                 205             


Thr Gln Val Lys Ile Trp Phe Gln Asn Lys Arg Ser Lys Phe Lys Lys 
    210                 215                 220                 


Leu Leu Lys Gln Gly Ser Asn Pro His Glu Ser Asp Pro Leu Gln Gly 
225                 230                 235                 240 


Ser Ala Ala Leu Ser Pro Arg Ser Pro Ala Leu Pro Pro Val Trp Asp 
                245                 250                 255     


Val Ser Ala Ser Ala Lys Gly Val Ser Met Pro Pro Asn Ser Tyr Met 
            260                 265                 270         


Pro Gly Tyr Ser His Trp Tyr Ser Ser Pro His Gln Asp Thr Met Gln 
        275                 280                 285             


Arg Pro Gln Met Met 
    290             


<210>  3117
<211>  1785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMBT1__Homo_sapiens__NP_004397

<400>  3117

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Gln 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro 
        595                 600                 605             


Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu Arg 
    610                 615                 620                 


Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr 
625                 630                 635                 640 


Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp 
                645                 650                 655     


Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala 
            660                 665                 670         


Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp 
        675                 680                 685             


Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His 
    690                 695                 700                 


Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val 
705                 710                 715                 720 


Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr Trp 
                725                 730                 735     


Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu 
            740                 745                 750         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        755                 760                 765             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn 
    770                 775                 780                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
785                 790                 795                 800 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                805                 810                 815     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            820                 825                 830         


His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        835                 840                 845             


Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr 
    850                 855                 860                 


Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser Glu Ser Thr Leu Ala 
865                 870                 875                 880 


Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Val 
                885                 890                 895     


Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr 
            900                 905                 910         


Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met 
        915                 920                 925             


Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser Gly Pro Ile Val 
    930                 935                 940                 


Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys 
945                 950                 955                 960 


Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala 
                965                 970                 975     


Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser Thr Pro Arg Pro Asp 
            980                 985                 990         


Thr Trp Leu Thr Thr Asn Leu Pro  Ala Leu Thr Val Gly  Ser Glu Ser 
        995                 1000                 1005             


Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly Asp Arg  Cys Arg Gly 
    1010                 1015                 1020             


Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp 
    1025                 1030                 1035             


Asp Ser  Trp Asp Thr Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu 
    1040                 1045                 1050             


Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly 
    1055                 1060                 1065             


Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly 
    1070                 1075                 1080             


Asn Glu  Ser Tyr Leu Trp Ser  Cys Pro His Lys Gly  Trp Leu Thr 
    1085                 1090                 1095             


His Asn  Cys Gly His His Glu  Asp Ala Gly Val Ile  Cys Ser Ala 
    1100                 1105                 1110             


Thr Gln  Ile Asn Ser Thr Thr  Thr Asp Trp Trp His  Pro Thr Thr 
    1115                 1120                 1125             


Thr Thr  Thr Ala Arg Pro Ser  Ser Asn Cys Gly Gly  Phe Leu Phe 
    1130                 1135                 1140             


Tyr Ala  Ser Gly Thr Phe Ser  Ser Pro Ser Tyr Pro  Ala Tyr Tyr 
    1145                 1150                 1155             


Pro Asn  Asn Ala Lys Cys Val  Trp Glu Ile Glu Val  Asn Ser Gly 
    1160                 1165                 1170             


Tyr Arg  Ile Asn Leu Gly Phe  Ser Asn Leu Lys Leu  Glu Ala His 
    1175                 1180                 1185             


His Asn  Cys Ser Phe Asp Tyr  Val Glu Ile Phe Asp  Gly Ser Leu 
    1190                 1195                 1200             


Asn Ser  Ser Leu Leu Leu Gly  Lys Ile Cys Asn Asp  Thr Arg Gln 
    1205                 1210                 1215             


Ile Phe  Thr Ser Ser Tyr Asn  Arg Met Thr Ile His  Phe Arg Ser 
    1220                 1225                 1230             


Asp Ile  Ser Phe Gln Asn Thr  Gly Phe Leu Ala Trp  Tyr Asn Ser 
    1235                 1240                 1245             


Phe Pro  Ser Asp Ala Thr Leu  Arg Leu Val Asn Leu  Asn Ser Ser 
    1250                 1255                 1260             


Tyr Gly  Leu Cys Ala Gly Arg  Val Glu Ile Tyr His  Gly Gly Thr 
    1265                 1270                 1275             


Trp Gly  Thr Val Cys Asp Asp  Ser Trp Thr Ile Gln  Glu Ala Glu 
    1280                 1285                 1290             


Val Val  Cys Arg Gln Leu Gly  Cys Gly Arg Ala Val  Ser Ala Leu 
    1295                 1300                 1305             


Gly Asn  Ala Tyr Phe Gly Ser  Gly Ser Gly Pro Ile  Thr Leu Asp 
    1310                 1315                 1320             


Asp Val  Glu Cys Ser Gly Thr  Glu Ser Thr Leu Trp  Gln Cys Arg 
    1325                 1330                 1335             


Asn Arg  Gly Trp Phe Ser His  Asn Cys Asn His Arg  Glu Asp Ala 
    1340                 1345                 1350             


Gly Val  Ile Cys Ser Gly Asn  His Leu Ser Thr Pro  Ala Pro Phe 
    1355                 1360                 1365             


Leu Asn  Ile Thr Arg Pro Asn  Thr Asp Tyr Ser Cys  Gly Gly Phe 
    1370                 1375                 1380             


Leu Ser  Gln Pro Ser Gly Asp  Phe Ser Ser Pro Phe  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Tyr  Pro Asn Asn Ala Lys  Cys Val Trp Asp Ile  Glu Val Gln 
    1400                 1405                 1410             


Asn Asn  Tyr Arg Val Thr Val  Ile Phe Arg Asp Val  Gln Leu Glu 
    1415                 1420                 1425             


Gly Gly  Cys Asn Tyr Asp Tyr  Ile Glu Val Phe Asp  Gly Pro Tyr 
    1430                 1435                 1440             


Arg Ser  Ser Pro Leu Ile Ala  Arg Val Cys Asp Gly  Ala Arg Gly 
    1445                 1450                 1455             


Ser Phe  Thr Ser Ser Ser Asn  Phe Met Ser Ile Arg  Phe Ile Ser 
    1460                 1465                 1470             


Asp His  Ser Ile Thr Arg Arg  Gly Phe Arg Ala Glu  Tyr Tyr Ser 
    1475                 1480                 1485             


Ser Pro  Ser Asn Asp Ser Thr  Asn Leu Leu Cys Leu  Pro Asn His 
    1490                 1495                 1500             


Met Gln  Ala Ser Val Ser Arg  Ser Tyr Leu Gln Ser  Leu Gly Phe 
    1505                 1510                 1515             


Ser Ala  Ser Asp Leu Val Ile  Ser Thr Trp Asn Gly  Tyr Tyr Glu 
    1520                 1525                 1530             


Cys Arg  Pro Gln Ile Thr Pro  Asn Leu Val Ile Phe  Thr Ile Pro 
    1535                 1540                 1545             


Tyr Ser  Gly Cys Gly Thr Phe  Lys Gln Ala Asp Asn  Asp Thr Ile 
    1550                 1555                 1560             


Asp Tyr  Ser Asn Phe Leu Thr  Ala Ala Val Ser Gly  Gly Ile Ile 
    1565                 1570                 1575             


Lys Arg  Arg Thr Asp Leu Arg  Ile His Val Ser Cys  Arg Met Leu 
    1580                 1585                 1590             


Gln Asn  Thr Trp Val Asp Thr  Met Tyr Ile Ala Asn  Asp Thr Ile 
    1595                 1600                 1605             


His Val  Ala Asn Asn Thr Ile  Gln Val Glu Glu Val  Gln Tyr Gly 
    1610                 1615                 1620             


Asn Phe  Asp Val Asn Ile Ser  Phe Tyr Thr Ser Ser  Ser Phe Leu 
    1625                 1630                 1635             


Tyr Pro  Val Thr Ser Arg Pro  Tyr Tyr Val Asp Leu  Asn Gln Asp 
    1640                 1645                 1650             


Leu Tyr  Val Gln Ala Glu Ile  Leu His Ser Asp Ala  Val Leu Thr 
    1655                 1660                 1665             


Leu Phe  Val Asp Thr Cys Val  Ala Ser Pro Tyr Ser  Asn Asp Phe 
    1670                 1675                 1680             


Thr Ser  Leu Thr Tyr Asp Leu  Ile Arg Ser Gly Cys  Val Arg Asp 
    1685                 1690                 1695             


Asp Thr  Tyr Gly Pro Tyr Ser  Ser Pro Ser Leu Arg  Ile Ala Arg 
    1700                 1705                 1710             


Phe Arg  Phe Arg Ala Phe His  Phe Leu Asn Arg Phe  Pro Ser Val 
    1715                 1720                 1725             


Tyr Leu  Arg Cys Lys Met Val  Val Cys Arg Ala Tyr  Asp Pro Ser 
    1730                 1735                 1740             


Ser Arg  Cys Tyr Arg Gly Cys  Val Leu Arg Ser Lys  Arg Asp Val 
    1745                 1750                 1755             


Gly Ser  Tyr Gln Glu Lys Val  Asp Val Val Leu Gly  Pro Ile Gln 
    1760                 1765                 1770             


Leu Gln  Thr Pro Pro Arg Arg  Glu Glu Glu Pro Arg  
    1775                 1780                 1785 


<210>  3118
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMC1__Homo_sapiens__NP_008999

<400>  3118

Met Lys Glu Asp Gln Val Val Ala Glu Glu Pro Gly Phe Gln Asp Glu 
1               5                   10                  15      


Glu Glu Ser Leu Phe Gln Asp Ile Asp Leu Leu Gln Lys His Gly Ile 
            20                  25                  30          


Asn Val Ala Asp Ile Lys Lys Leu Lys Ser Val Gly Ile Cys Thr Ile 
        35                  40                  45              


Lys Gly Ile Gln Met Thr Thr Arg Arg Ala Leu Cys Asn Val Lys Gly 
    50                  55                  60                  


Leu Ser Glu Ala Lys Val Asp Lys Ile Lys Glu Ala Ala Asn Lys Leu 
65                  70                  75                  80  


Ile Glu Pro Gly Phe Leu Thr Ala Phe Glu Tyr Ser Glu Lys Arg Lys 
                85                  90                  95      


Met Val Phe His Ile Thr Thr Gly Ser Gln Glu Phe Asp Lys Leu Leu 
            100                 105                 110         


Gly Gly Gly Ile Glu Ser Met Ala Ile Thr Glu Ala Phe Gly Glu Phe 
        115                 120                 125             


Arg Thr Gly Lys Thr Gln Leu Ser His Thr Leu Cys Val Thr Ala Gln 
    130                 135                 140                 


Leu Pro Gly Ala Gly Gly Tyr Pro Gly Gly Lys Ile Ile Phe Ile Asp 
145                 150                 155                 160 


Thr Glu Asn Thr Phe Arg Pro Asp Arg Leu Arg Asp Ile Ala Asp Arg 
                165                 170                 175     


Phe Asn Val Asp His Asp Ala Val Leu Asp Asn Val Leu Tyr Ala Arg 
            180                 185                 190         


Ala Tyr Thr Ser Glu His Gln Met Glu Leu Leu Asp Tyr Val Ala Ala 
        195                 200                 205             


Lys Phe His Glu Glu Ala Gly Ile Phe Lys Leu Leu Ile Ile Asp Ser 
    210                 215                 220                 


Ile Met Ala Leu Phe Arg Val Asp Phe Ser Gly Arg Gly Glu Leu Ala 
225                 230                 235                 240 


Glu Arg Gln Gln Lys Leu Ala Gln Met Leu Ser Arg Leu Gln Lys Ile 
                245                 250                 255     


Ser Glu Glu Tyr Asn Val Ala Val Phe Val Thr Asn Gln Met Thr Ala 
            260                 265                 270         


Asp Pro Gly Ala Thr Met Thr Phe Gln Ala Asp Pro Lys Lys Pro Ile 
        275                 280                 285             


Gly Gly His Ile Leu Ala His Ala Ser Thr Thr Arg Ile Ser Leu Arg 
    290                 295                 300                 


Lys Gly Arg Gly Glu Leu Arg Ile Ala Lys Ile Tyr Asp Ser Pro Glu 
305                 310                 315                 320 


Met Pro Glu Asn Glu Ala Thr Phe Ala Ile Thr Ala Gly Gly Ile Gly 
                325                 330                 335     


Asp Ala Lys Glu 
            340 


<210>  3119
<211>  3677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMD__Homo_sapiens__NP_000100

<400>  3119

Met Glu Asp Glu Arg Glu Asp Val Gln Lys Lys Thr Phe Thr Lys Trp 
1               5                   10                  15      


Val Asn Ala Gln Phe Ser Lys Phe Gly Lys Gln His Ile Glu Asn Leu 
            20                  25                  30          


Phe Ser Asp Leu Gln Asp Gly Arg Arg Leu Leu Asp Leu Leu Glu Gly 
        35                  40                  45              


Leu Thr Gly Gln Lys Leu Pro Lys Glu Lys Gly Ser Thr Arg Val His 
    50                  55                  60                  


Ala Leu Asn Asn Val Asn Lys Ala Leu Arg Val Leu Gln Asn Asn Asn 
65                  70                  75                  80  


Val Asp Leu Val Asn Ile Gly Ser Thr Asp Ile Val Asp Gly Asn His 
                85                  90                  95      


Lys Leu Thr Leu Gly Leu Ile Trp Asn Ile Ile Leu His Trp Gln Val 
            100                 105                 110         


Lys Asn Val Met Lys Asn Ile Met Ala Gly Leu Gln Gln Thr Asn Ser 
        115                 120                 125             


Glu Lys Ile Leu Leu Ser Trp Val Arg Gln Ser Thr Arg Asn Tyr Pro 
    130                 135                 140                 


Gln Val Asn Val Ile Asn Phe Thr Thr Ser Trp Ser Asp Gly Leu Ala 
145                 150                 155                 160 


Leu Asn Ala Leu Ile His Ser His Arg Pro Asp Leu Phe Asp Trp Asn 
                165                 170                 175     


Ser Val Val Cys Gln Gln Ser Ala Thr Gln Arg Leu Glu His Ala Phe 
            180                 185                 190         


Asn Ile Ala Arg Tyr Gln Leu Gly Ile Glu Lys Leu Leu Asp Pro Glu 
        195                 200                 205             


Asp Val Asp Thr Thr Tyr Pro Asp Lys Lys Ser Ile Leu Met Tyr Ile 
    210                 215                 220                 


Thr Ser Leu Phe Gln Val Leu Pro Gln Gln Val Ser Ile Glu Ala Ile 
225                 230                 235                 240 


Gln Glu Val Glu Met Leu Pro Arg Pro Pro Lys Val Thr Lys Glu Glu 
                245                 250                 255     


His Phe Gln Leu His His Gln Met His Tyr Ser Gln Gln Ile Thr Val 
            260                 265                 270         


Ser Leu Ala Gln Gly Tyr Glu Arg Thr Ser Ser Pro Lys Pro Arg Phe 
        275                 280                 285             


Lys Ser Tyr Ala Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro 
    290                 295                 300                 


Thr Arg Ser Pro Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys 
305                 310                 315                 320 


Ser Phe Gly Ser Ser Leu Met Glu Ser Glu Val Asn Leu Asp Arg Tyr 
                325                 330                 335     


Gln Thr Ala Leu Glu Glu Val Leu Ser Trp Leu Leu Ser Ala Glu Asp 
            340                 345                 350         


Thr Leu Gln Ala Gln Gly Glu Ile Ser Asn Asp Val Glu Val Val Lys 
        355                 360                 365             


Asp Gln Phe His Thr His Glu Gly Tyr Met Met Asp Leu Thr Ala His 
    370                 375                 380                 


Gln Gly Arg Val Gly Asn Ile Leu Gln Leu Gly Ser Lys Leu Ile Gly 
385                 390                 395                 400 


Thr Gly Lys Leu Ser Glu Asp Glu Glu Thr Glu Val Gln Glu Gln Met 
                405                 410                 415     


Asn Leu Leu Asn Ser Arg Trp Glu Cys Leu Arg Val Ala Ser Met Glu 
            420                 425                 430         


Lys Gln Ser Asn Leu His Arg Val Leu Met Asp Leu Gln Asn Gln Lys 
        435                 440                 445             


Leu Lys Glu Leu Asn Asp Trp Leu Thr Lys Thr Glu Glu Arg Thr Arg 
    450                 455                 460                 


Lys Met Glu Glu Glu Pro Leu Gly Pro Asp Leu Glu Asp Leu Lys Arg 
465                 470                 475                 480 


Gln Val Gln Gln His Lys Val Leu Gln Glu Asp Leu Glu Gln Glu Gln 
                485                 490                 495     


Val Arg Val Asn Ser Leu Thr His Met Val Val Val Val Asp Glu Ser 
            500                 505                 510         


Ser Gly Asp His Ala Thr Ala Ala Leu Glu Glu Gln Leu Lys Val Leu 
        515                 520                 525             


Gly Asp Arg Trp Ala Asn Ile Cys Arg Trp Thr Glu Asp Arg Trp Val 
    530                 535                 540                 


Leu Leu Gln Asp Ile Leu Leu Lys Trp Gln Arg Leu Thr Glu Glu Gln 
545                 550                 555                 560 


Cys Leu Phe Ser Ala Trp Leu Ser Glu Lys Glu Asp Ala Val Asn Lys 
                565                 570                 575     


Ile His Thr Thr Gly Phe Lys Asp Gln Asn Glu Met Leu Ser Ser Leu 
            580                 585                 590         


Gln Lys Leu Ala Val Leu Lys Ala Asp Leu Glu Lys Lys Lys Gln Ser 
        595                 600                 605             


Met Gly Lys Leu Tyr Ser Leu Lys Gln Asp Leu Leu Ser Thr Leu Lys 
    610                 615                 620                 


Asn Lys Ser Val Thr Gln Lys Thr Glu Ala Trp Leu Asp Asn Phe Ala 
625                 630                 635                 640 


Arg Cys Trp Asp Asn Leu Val Gln Lys Leu Glu Lys Ser Thr Ala Gln 
                645                 650                 655     


Ile Ser Gln Ala Val Thr Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr 
            660                 665                 670         


Val Met Glu Thr Val Thr Thr Val Thr Thr Arg Glu Gln Ile Leu Val 
        675                 680                 685             


Lys His Ala Gln Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg 
    690                 695                 700                 


Gln Ile Thr Val Asp Ser Glu Ile Arg Lys Arg Leu Asp Val Asp Ile 
705                 710                 715                 720 


Thr Glu Leu His Ser Trp Ile Thr Arg Ser Glu Ala Val Leu Gln Ser 
                725                 730                 735     


Pro Glu Phe Ala Ile Phe Arg Lys Glu Gly Asn Phe Ser Asp Leu Lys 
            740                 745                 750         


Glu Lys Val Asn Ala Ile Glu Arg Glu Lys Ala Glu Lys Phe Arg Lys 
        755                 760                 765             


Leu Gln Asp Ala Ser Arg Ser Ala Gln Ala Leu Val Glu Gln Met Val 
    770                 775                 780                 


Asn Glu Gly Val Asn Ala Asp Ser Ile Lys Gln Ala Ser Glu Gln Leu 
785                 790                 795                 800 


Asn Ser Arg Trp Ile Glu Phe Cys Gln Leu Leu Ser Glu Arg Leu Asn 
                805                 810                 815     


Trp Leu Glu Tyr Gln Asn Asn Ile Ile Ala Phe Tyr Asn Gln Leu Gln 
            820                 825                 830         


Gln Leu Glu Gln Met Thr Thr Thr Ala Glu Asn Trp Leu Lys Ile Gln 
        835                 840                 845             


Pro Thr Thr Pro Ser Glu Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile 
    850                 855                 860                 


Cys Lys Asp Glu Val Asn Arg Leu Ser Gly Leu Gln Pro Gln Ile Glu 
865                 870                 875                 880 


Arg Leu Lys Ile Gln Ser Ile Ala Leu Lys Glu Lys Gly Gln Gly Pro 
                885                 890                 895     


Met Phe Leu Asp Ala Asp Phe Val Ala Phe Thr Asn His Phe Lys Gln 
            900                 905                 910         


Val Phe Ser Asp Val Gln Ala Arg Glu Lys Glu Leu Gln Thr Ile Phe 
        915                 920                 925             


Asp Thr Leu Pro Pro Met Arg Tyr Gln Glu Thr Met Ser Ala Ile Arg 
    930                 935                 940                 


Thr Trp Val Gln Gln Ser Glu Thr Lys Leu Ser Ile Pro Gln Leu Ser 
945                 950                 955                 960 


Val Thr Asp Tyr Glu Ile Met Glu Gln Arg Leu Gly Glu Leu Gln Ala 
                965                 970                 975     


Leu Gln Ser Ser Leu Gln Glu Gln Gln Ser Gly Leu Tyr Tyr Leu Ser 
            980                 985                 990         


Thr Thr Val Lys Glu Met Ser Lys  Lys Ala Pro Ser Glu  Ile Ser Arg 
        995                 1000                 1005             


Lys Tyr  Gln Ser Glu Phe Glu  Glu Ile Glu Gly Arg  Trp Lys Lys 
    1010                 1015                 1020             


Leu Ser  Ser Gln Leu Val Glu  His Cys Gln Lys Leu  Glu Glu Gln 
    1025                 1030                 1035             


Met Asn  Lys Leu Arg Lys Ile  Gln Asn His Ile Gln  Thr Leu Lys 
    1040                 1045                 1050             


Lys Trp  Met Ala Glu Val Asp  Val Phe Leu Lys Glu  Glu Trp Pro 
    1055                 1060                 1065             


Ala Leu  Gly Asp Ser Glu Ile  Leu Lys Lys Gln Leu  Lys Gln Cys 
    1070                 1075                 1080             


Arg Leu  Leu Val Ser Asp Ile  Gln Thr Ile Gln Pro  Ser Leu Asn 
    1085                 1090                 1095             


Ser Val  Asn Glu Gly Gly Gln  Lys Ile Lys Asn Glu  Ala Glu Pro 
    1100                 1105                 1110             


Glu Phe  Ala Ser Arg Leu Glu  Thr Glu Leu Lys Glu  Leu Asn Thr 
    1115                 1120                 1125             


Gln Trp  Asp His Met Cys Gln  Gln Val Tyr Ala Arg  Lys Glu Ala 
    1130                 1135                 1140             


Leu Lys  Gly Gly Leu Glu Lys  Thr Val Ser Leu Gln  Lys Asp Leu 
    1145                 1150                 1155             


Ser Glu  Met His Glu Trp Met  Thr Gln Ala Glu Glu  Glu Tyr Leu 
    1160                 1165                 1170             


Glu Arg  Asp Phe Glu Tyr Lys  Thr Pro Asp Glu Leu  Gln Lys Ala 
    1175                 1180                 1185             


Val Glu  Glu Met Lys Arg Ala  Lys Glu Glu Ala Gln  Gln Lys Glu 
    1190                 1195                 1200             


Ala Lys  Val Lys Leu Leu Thr  Glu Ser Val Asn Ser  Val Ile Ala 
    1205                 1210                 1215             


Gln Ala  Pro Pro Val Ala Gln  Glu Ala Leu Lys Lys  Glu Leu Glu 
    1220                 1225                 1230             


Thr Leu  Thr Thr Asn Tyr Gln  Trp Leu Cys Thr Arg  Leu Asn Gly 
    1235                 1240                 1245             


Lys Cys  Lys Thr Leu Glu Glu  Val Trp Ala Cys Trp  His Glu Leu 
    1250                 1255                 1260             


Leu Ser  Tyr Leu Glu Lys Ala  Asn Lys Trp Leu Asn  Glu Val Glu 
    1265                 1270                 1275             


Phe Lys  Leu Lys Thr Thr Glu  Asn Ile Pro Gly Gly  Ala Glu Glu 
    1280                 1285                 1290             


Ile Ser  Glu Val Leu Asp Ser  Leu Glu Asn Leu Met  Arg His Ser 
    1295                 1300                 1305             


Glu Asp  Asn Pro Asn Gln Ile  Arg Ile Leu Ala Gln  Thr Leu Thr 
    1310                 1315                 1320             


Asp Gly  Gly Val Met Asp Glu  Leu Ile Asn Glu Glu  Leu Glu Thr 
    1325                 1330                 1335             


Phe Asn  Ser Arg Trp Arg Glu  Leu His Glu Glu Ala  Val Arg Arg 
    1340                 1345                 1350             


Gln Lys  Leu Leu Glu Gln Ser  Ile Gln Ser Ala Gln  Glu Thr Glu 
    1355                 1360                 1365             


Lys Ser  Leu His Leu Ile Gln  Glu Ser Leu Thr Phe  Ile Asp Lys 
    1370                 1375                 1380             


Gln Leu  Ala Ala Tyr Ile Ala  Asp Lys Val Asp Ala  Ala Gln Met 
    1385                 1390                 1395             


Pro Gln  Glu Ala Gln Lys Ile  Gln Ser Asp Leu Thr  Ser His Glu 
    1400                 1405                 1410             


Ile Ser  Leu Glu Glu Met Lys  Lys His Asn Gln Gly  Lys Glu Ala 
    1415                 1420                 1425             


Ala Gln  Arg Val Leu Ser Gln  Ile Asp Val Ala Gln  Lys Lys Leu 
    1430                 1435                 1440             


Gln Asp  Val Ser Met Lys Phe  Arg Leu Phe Gln Lys  Pro Ala Asn 
    1445                 1450                 1455             


Phe Glu  Gln Arg Leu Gln Glu  Ser Lys Met Ile Leu  Asp Glu Val 
    1460                 1465                 1470             


Lys Met  His Leu Pro Ala Leu  Glu Thr Lys Ser Val  Glu Gln Glu 
    1475                 1480                 1485             


Val Val  Gln Ser Gln Leu Asn  His Cys Val Asn Leu  Tyr Lys Ser 
    1490                 1495                 1500             


Leu Ser  Glu Val Lys Ser Glu  Val Glu Met Val Ile  Lys Thr Gly 
    1505                 1510                 1515             


Arg Gln  Ile Val Gln Lys Lys  Gln Thr Glu Asn Pro  Lys Glu Leu 
    1520                 1525                 1530             


Asp Glu  Arg Val Thr Ala Leu  Lys Leu His Tyr Asn  Glu Leu Gly 
    1535                 1540                 1545             


Ala Lys  Val Thr Glu Arg Lys  Gln Gln Leu Glu Lys  Cys Leu Lys 
    1550                 1555                 1560             


Leu Ser  Arg Lys Met Arg Lys  Glu Met Asn Val Leu  Thr Glu Trp 
    1565                 1570                 1575             


Leu Ala  Ala Thr Asp Met Glu  Leu Thr Lys Arg Ser  Ala Val Glu 
    1580                 1585                 1590             


Gly Met  Pro Ser Asn Leu Asp  Ser Glu Val Ala Trp  Gly Lys Ala 
    1595                 1600                 1605             


Thr Gln  Lys Glu Ile Glu Lys  Gln Lys Val His Leu  Lys Ser Ile 
    1610                 1615                 1620             


Thr Glu  Val Gly Glu Ala Leu  Lys Thr Val Leu Gly  Lys Lys Glu 
    1625                 1630                 1635             


Thr Leu  Val Glu Asp Lys Leu  Ser Leu Leu Asn Ser  Asn Trp Ile 
    1640                 1645                 1650             


Ala Val  Thr Ser Arg Ala Glu  Glu Trp Leu Asn Leu  Leu Leu Glu 
    1655                 1660                 1665             


Tyr Gln  Lys His Met Glu Thr  Phe Asp Gln Asn Val  Asp His Ile 
    1670                 1675                 1680             


Thr Lys  Trp Ile Ile Gln Ala  Asp Thr Leu Leu Asp  Glu Ser Glu 
    1685                 1690                 1695             


Lys Lys  Lys Pro Gln Gln Lys  Glu Asp Val Leu Lys  Arg Leu Lys 
    1700                 1705                 1710             


Ala Glu  Leu Asn Asp Ile Arg  Pro Lys Val Asp Ser  Thr Arg Asp 
    1715                 1720                 1725             


Gln Ala  Ala Asn Leu Met Ala  Asn Arg Gly Asp His  Cys Arg Lys 
    1730                 1735                 1740             


Leu Val  Glu Pro Gln Ile Ser  Glu Leu Asn His Arg  Phe Ala Ala 
    1745                 1750                 1755             


Ile Ser  His Arg Ile Lys Thr  Gly Lys Ala Ser Ile  Pro Leu Lys 
    1760                 1765                 1770             


Glu Leu  Glu Gln Phe Asn Ser  Asp Ile Gln Lys Leu  Leu Glu Pro 
    1775                 1780                 1785             


Leu Glu  Ala Glu Ile Gln Gln  Gly Val Asn Leu Lys  Glu Glu Asp 
    1790                 1795                 1800             


Phe Asn  Lys Asp Met Asn Glu  Asp Asn Glu Gly Thr  Val Lys Glu 
    1805                 1810                 1815             


Leu Leu  Gln Arg Gly Asp Asn  Leu Gln Gln Arg Ile  Thr Asp Glu 
    1820                 1825                 1830             


Arg Lys  Arg Glu Glu Ile Lys  Ile Lys Gln Gln Leu  Leu Gln Thr 
    1835                 1840                 1845             


Lys His  Asn Ala Leu Lys Asp  Leu Arg Ser Gln Arg  Arg Lys Lys 
    1850                 1855                 1860             


Ala Leu  Glu Ile Ser His Gln  Trp Tyr Gln Tyr Lys  Arg Gln Ala 
    1865                 1870                 1875             


Asp Asp  Leu Leu Lys Cys Leu  Asp Asp Ile Glu Lys  Lys Leu Ala 
    1880                 1885                 1890             


Ser Leu  Pro Glu Pro Arg Asp  Glu Arg Lys Ile Lys  Glu Ile Asp 
    1895                 1900                 1905             


Arg Glu  Leu Gln Lys Lys Lys  Glu Glu Leu Asn Ala  Val Arg Arg 
    1910                 1915                 1920             


Gln Ala  Glu Gly Leu Ser Glu  Asp Gly Ala Ala Met  Ala Val Glu 
    1925                 1930                 1935             


Pro Thr  Gln Ile Gln Leu Ser  Lys Arg Trp Arg Glu  Ile Glu Ser 
    1940                 1945                 1950             


Lys Phe  Ala Gln Phe Arg Arg  Leu Asn Phe Ala Gln  Ile His Thr 
    1955                 1960                 1965             


Val Arg  Glu Glu Thr Met Met  Val Met Thr Glu Asp  Met Pro Leu 
    1970                 1975                 1980             


Glu Ile  Ser Tyr Val Pro Ser  Thr Tyr Leu Thr Glu  Ile Thr His 
    1985                 1990                 1995             


Val Ser  Gln Ala Leu Leu Glu  Val Glu Gln Leu Leu  Asn Ala Pro 
    2000                 2005                 2010             


Asp Leu  Cys Ala Lys Asp Phe  Glu Asp Leu Phe Lys  Gln Glu Glu 
    2015                 2020                 2025             


Ser Leu  Lys Asn Ile Lys Asp  Ser Leu Gln Gln Ser  Ser Gly Arg 
    2030                 2035                 2040             


Ile Asp  Ile Ile His Ser Lys  Lys Thr Ala Ala Leu  Gln Ser Ala 
    2045                 2050                 2055             


Thr Pro  Val Glu Arg Val Lys  Leu Gln Glu Ala Leu  Ser Gln Leu 
    2060                 2065                 2070             


Asp Phe  Gln Trp Glu Lys Val  Asn Lys Met Tyr Lys  Asp Arg Gln 
    2075                 2080                 2085             


Gly Arg  Phe Asp Arg Ser Val  Glu Lys Trp Arg Arg  Phe His Tyr 
    2090                 2095                 2100             


Asp Ile  Lys Ile Phe Asn Gln  Trp Leu Thr Glu Ala  Glu Gln Phe 
    2105                 2110                 2115             


Leu Arg  Lys Thr Gln Ile Pro  Glu Asn Trp Glu His  Ala Lys Tyr 
    2120                 2125                 2130             


Lys Trp  Tyr Leu Lys Glu Leu  Gln Asp Gly Ile Gly  Gln Arg Gln 
    2135                 2140                 2145             


Thr Val  Val Arg Thr Leu Asn  Ala Thr Gly Glu Glu  Ile Ile Gln 
    2150                 2155                 2160             


Gln Ser  Ser Lys Thr Asp Ala  Ser Ile Leu Gln Glu  Lys Leu Gly 
    2165                 2170                 2175             


Ser Leu  Asn Leu Arg Trp Gln  Glu Val Cys Lys Gln  Leu Ser Asp 
    2180                 2185                 2190             


Arg Lys  Lys Arg Leu Glu Glu  Gln Lys Asn Ile Leu  Ser Glu Phe 
    2195                 2200                 2205             


Gln Arg  Asp Leu Asn Glu Phe  Val Leu Trp Leu Glu  Glu Ala Asp 
    2210                 2215                 2220             


Asn Ile  Ala Ser Ile Pro Leu  Glu Pro Gly Lys Glu  Gln Gln Leu 
    2225                 2230                 2235             


Lys Glu  Lys Leu Glu Gln Val  Lys Leu Leu Val Glu  Glu Leu Pro 
    2240                 2245                 2250             


Leu Arg  Gln Gly Ile Leu Lys  Gln Leu Asn Glu Thr  Gly Gly Pro 
    2255                 2260                 2265             


Val Leu  Val Ser Ala Pro Ile  Ser Pro Glu Glu Gln  Asp Lys Leu 
    2270                 2275                 2280             


Glu Asn  Lys Leu Lys Gln Thr  Asn Leu Gln Trp Ile  Lys Val Ser 
    2285                 2290                 2295             


Arg Ala  Leu Pro Glu Lys Gln  Gly Glu Ile Glu Ala  Gln Ile Lys 
    2300                 2305                 2310             


Asp Leu  Gly Gln Leu Glu Lys  Lys Leu Glu Asp Leu  Glu Glu Gln 
    2315                 2320                 2325             


Leu Asn  His Leu Leu Leu Trp  Leu Ser Pro Ile Arg  Asn Gln Leu 
    2330                 2335                 2340             


Glu Ile  Tyr Asn Gln Pro Asn  Gln Glu Gly Pro Phe  Asp Val Gln 
    2345                 2350                 2355             


Glu Thr  Glu Ile Ala Val Gln  Ala Lys Gln Pro Asp  Val Glu Glu 
    2360                 2365                 2370             


Ile Leu  Ser Lys Gly Gln His  Leu Tyr Lys Glu Lys  Pro Ala Thr 
    2375                 2380                 2385             


Gln Pro  Val Lys Arg Lys Leu  Glu Asp Leu Ser Ser  Glu Trp Lys 
    2390                 2395                 2400             


Ala Val  Asn Arg Leu Leu Gln  Glu Leu Arg Ala Lys  Gln Pro Asp 
    2405                 2410                 2415             


Leu Ala  Pro Gly Leu Thr Thr  Ile Gly Ala Ser Pro  Thr Gln Thr 
    2420                 2425                 2430             


Val Thr  Leu Val Thr Gln Pro  Val Val Thr Lys Glu  Thr Ala Ile 
    2435                 2440                 2445             


Ser Lys  Leu Glu Met Pro Ser  Ser Leu Met Leu Glu  Val Pro Ala 
    2450                 2455                 2460             


Leu Ala  Asp Phe Asn Arg Ala  Trp Thr Glu Leu Thr  Asp Trp Leu 
    2465                 2470                 2475             


Ser Leu  Leu Asp Gln Val Ile  Lys Ser Gln Arg Val  Met Val Gly 
    2480                 2485                 2490             


Asp Leu  Glu Asp Ile Asn Glu  Met Ile Ile Lys Gln  Lys Ala Thr 
    2495                 2500                 2505             


Met Gln  Asp Leu Glu Gln Arg  Arg Pro Gln Leu Glu  Glu Leu Ile 
    2510                 2515                 2520             


Thr Ala  Ala Gln Asn Leu Lys  Asn Lys Thr Ser Asn  Gln Glu Ala 
    2525                 2530                 2535             


Arg Thr  Ile Ile Thr Asp Arg  Ile Glu Arg Ile Gln  Asn Gln Trp 
    2540                 2545                 2550             


Asp Glu  Val Gln Glu His Leu  Gln Asn Arg Arg Gln  Gln Leu Asn 
    2555                 2560                 2565             


Glu Met  Leu Lys Asp Ser Thr  Gln Trp Leu Glu Ala  Lys Glu Glu 
    2570                 2575                 2580             


Ala Glu  Gln Val Leu Gly Gln  Ala Arg Ala Lys Leu  Glu Ser Trp 
    2585                 2590                 2595             


Lys Glu  Gly Pro Tyr Thr Val  Asp Ala Ile Gln Lys  Lys Ile Thr 
    2600                 2605                 2610             


Glu Thr  Lys Gln Leu Ala Lys  Asp Leu Arg Gln Trp  Gln Thr Asn 
    2615                 2620                 2625             


Val Asp  Val Ala Asn Asp Leu  Ala Leu Lys Leu Leu  Arg Asp Tyr 
    2630                 2635                 2640             


Ser Ala  Asp Asp Thr Arg Lys  Val His Met Ile Thr  Glu Asn Ile 
    2645                 2650                 2655             


Asn Ala  Ser Trp Arg Ser Ile  His Lys Arg Val Ser  Glu Arg Glu 
    2660                 2665                 2670             


Ala Ala  Leu Glu Glu Thr His  Arg Leu Leu Gln Gln  Phe Pro Leu 
    2675                 2680                 2685             


Asp Leu  Glu Lys Phe Leu Ala  Trp Leu Thr Glu Ala  Glu Thr Thr 
    2690                 2695                 2700             


Ala Asn  Val Leu Gln Asp Ala  Thr Arg Lys Glu Arg  Leu Leu Glu 
    2705                 2710                 2715             


Asp Ser  Lys Gly Val Lys Glu  Leu Met Lys Gln Trp  Gln Asp Leu 
    2720                 2725                 2730             


Gln Gly  Glu Ile Glu Ala His  Thr Asp Val Tyr His  Asn Leu Asp 
    2735                 2740                 2745             


Glu Asn  Ser Gln Lys Ile Leu  Arg Ser Leu Glu Gly  Ser Asp Asp 
    2750                 2755                 2760             


Ala Val  Leu Leu Gln Arg Arg  Leu Asp Asn Met Asn  Phe Lys Trp 
    2765                 2770                 2775             


Ser Glu  Leu Arg Lys Lys Ser  Leu Asn Ile Arg Ser  His Leu Glu 
    2780                 2785                 2790             


Ala Ser  Ser Asp Gln Trp Lys  Arg Leu His Leu Ser  Leu Gln Glu 
    2795                 2800                 2805             


Leu Leu  Val Trp Leu Gln Leu  Lys Asp Asp Glu Leu  Ser Arg Gln 
    2810                 2815                 2820             


Ala Pro  Ile Gly Gly Asp Phe  Pro Ala Val Gln Lys  Gln Asn Asp 
    2825                 2830                 2835             


Val His  Arg Ala Phe Lys Arg  Glu Leu Lys Thr Lys  Glu Pro Val 
    2840                 2845                 2850             


Ile Met  Ser Thr Leu Glu Thr  Val Arg Ile Phe Leu  Thr Glu Gln 
    2855                 2860                 2865             


Pro Leu  Glu Gly Leu Glu Lys  Leu Tyr Gln Glu Pro  Arg Glu Leu 
    2870                 2875                 2880             


Pro Pro  Glu Glu Arg Ala Gln  Asn Val Thr Arg Leu  Leu Arg Lys 
    2885                 2890                 2895             


Gln Ala  Glu Glu Val Asn Thr  Glu Trp Glu Lys Leu  Asn Leu His 
    2900                 2905                 2910             


Ser Ala  Asp Trp Gln Arg Lys  Ile Asp Glu Thr Leu  Glu Arg Leu 
    2915                 2920                 2925             


Gln Glu  Leu Gln Glu Ala Thr  Asp Glu Leu Asp Leu  Lys Leu Arg 
    2930                 2935                 2940             


Gln Ala  Glu Val Ile Lys Gly  Ser Trp Gln Pro Val  Gly Asp Leu 
    2945                 2950                 2955             


Leu Ile  Asp Ser Leu Gln Asp  His Leu Glu Lys Val  Lys Ala Leu 
    2960                 2965                 2970             


Arg Gly  Glu Ile Ala Pro Leu  Lys Glu Asn Val Ser  His Val Asn 
    2975                 2980                 2985             


Asp Leu  Ala Arg Gln Leu Thr  Thr Leu Gly Ile Gln  Leu Ser Pro 
    2990                 2995                 3000             


Tyr Asn  Leu Ser Thr Leu Glu  Asp Leu Asn Thr Arg  Trp Lys Leu 
    3005                 3010                 3015             


Leu Gln  Val Ala Val Glu Asp  Arg Val Arg Gln Leu  His Glu Ala 
    3020                 3025                 3030             


His Arg  Asp Phe Gly Pro Ala  Ser Gln His Phe Leu  Ser Thr Ser 
    3035                 3040                 3045             


Val Gln  Gly Pro Trp Glu Arg  Ala Ile Ser Pro Asn  Lys Val Pro 
    3050                 3055                 3060             


Tyr Tyr  Ile Asn His Glu Thr  Gln Thr Thr Cys Trp  Asp His Pro 
    3065                 3070                 3075             


Lys Met  Thr Glu Leu Tyr Gln  Ser Leu Ala Asp Leu  Asn Asn Val 
    3080                 3085                 3090             


Arg Phe  Ser Ala Tyr Arg Thr  Ala Met Lys Leu Arg  Arg Leu Gln 
    3095                 3100                 3105             


Lys Ala  Leu Cys Leu Asp Leu  Leu Ser Leu Ser Ala  Ala Cys Asp 
    3110                 3115                 3120             


Ala Leu  Asp Gln His Asn Leu  Lys Gln Asn Asp Gln  Pro Met Asp 
    3125                 3130                 3135             


Ile Leu  Gln Ile Ile Asn Cys  Leu Thr Thr Ile Tyr  Asp Arg Leu 
    3140                 3145                 3150             


Glu Gln  Glu His Asn Asn Leu  Val Asn Val Pro Leu  Cys Val Asp 
    3155                 3160                 3165             


Met Cys  Leu Asn Trp Leu Leu  Asn Val Tyr Asp Thr  Gly Arg Thr 
    3170                 3175                 3180             


Gly Arg  Ile Arg Val Leu Ser  Phe Lys Thr Gly Ile  Ile Ser Leu 
    3185                 3190                 3195             


Cys Lys  Ala His Leu Glu Asp  Lys Tyr Arg Tyr Leu  Phe Lys Gln 
    3200                 3205                 3210             


Val Ala  Ser Ser Thr Gly Phe  Cys Asp Gln Arg Arg  Leu Gly Leu 
    3215                 3220                 3225             


Leu Leu  His Asp Ser Ile Gln  Ile Pro Arg Gln Leu  Gly Glu Val 
    3230                 3235                 3240             


Ala Ser  Phe Gly Gly Ser Asn  Ile Glu Pro Ser Val  Arg Ser Cys 
    3245                 3250                 3255             


Phe Gln  Phe Ala Asn Asn Lys  Pro Glu Ile Glu Ala  Ala Leu Phe 
    3260                 3265                 3270             


Leu Asp  Trp Met Arg Leu Glu  Pro Gln Ser Met Val  Trp Leu Pro 
    3275                 3280                 3285             


Val Leu  His Arg Val Ala Ala  Ala Glu Thr Ala Lys  His Gln Ala 
    3290                 3295                 3300             


Lys Cys  Asn Ile Cys Lys Glu  Cys Pro Ile Ile Gly  Phe Arg Tyr 
    3305                 3310                 3315             


Arg Ser  Leu Lys His Phe Asn  Tyr Asp Ile Cys Gln  Ser Cys Phe 
    3320                 3325                 3330             


Phe Ser  Gly Arg Val Ala Lys  Gly His Lys Met His  Tyr Pro Met 
    3335                 3340                 3345             


Val Glu  Tyr Cys Thr Pro Thr  Thr Ser Gly Glu Asp  Val Arg Asp 
    3350                 3355                 3360             


Phe Ala  Lys Val Leu Lys Asn  Lys Phe Arg Thr Lys  Arg Tyr Phe 
    3365                 3370                 3375             


Ala Lys  His Pro Arg Met Gly  Tyr Leu Pro Val Gln  Thr Val Leu 
    3380                 3385                 3390             


Glu Gly  Asp Asn Met Glu Thr  Pro Val Thr Leu Ile  Asn Phe Trp 
    3395                 3400                 3405             


Pro Val  Asp Ser Ala Pro Ala  Ser Ser Pro Gln Leu  Ser His Asp 
    3410                 3415                 3420             


Asp Thr  His Ser Arg Ile Glu  His Tyr Ala Ser Arg  Leu Ala Glu 
    3425                 3430                 3435             


Met Glu  Asn Ser Asn Gly Ser  Tyr Leu Asn Asp Ser  Ile Ser Pro 
    3440                 3445                 3450             


Asn Glu  Ser Ile Asp Asp Glu  His Leu Leu Ile Gln  His Tyr Cys 
    3455                 3460                 3465             


Gln Ser  Leu Asn Gln Asp Ser  Pro Leu Ser Gln Pro  Arg Ser Pro 
    3470                 3475                 3480             


Ala Gln  Ile Leu Ile Ser Leu  Glu Ser Glu Glu Arg  Gly Glu Leu 
    3485                 3490                 3495             


Glu Arg  Ile Leu Ala Asp Leu  Glu Glu Glu Asn Arg  Asn Leu Gln 
    3500                 3505                 3510             


Ala Glu  Tyr Asp Arg Leu Lys  Gln Gln His Glu His  Lys Gly Leu 
    3515                 3520                 3525             


Ser Pro  Leu Pro Ser Pro Pro  Glu Met Met Pro Thr  Ser Pro Gln 
    3530                 3535                 3540             


Ser Pro  Arg Asp Ala Glu Leu  Ile Ala Glu Ala Lys  Leu Leu Arg 
    3545                 3550                 3555             


Gln His  Lys Gly Arg Leu Glu  Ala Arg Met Gln Ile  Leu Glu Asp 
    3560                 3565                 3570             


His Asn  Lys Gln Leu Glu Ser  Gln Leu His Arg Leu  Arg Gln Leu 
    3575                 3580                 3585             


Leu Glu  Gln Pro Gln Ala Glu  Ala Lys Val Asn Gly  Thr Thr Val 
    3590                 3595                 3600             


Ser Ser  Pro Ser Thr Ser Leu  Gln Arg Ser Asp Ser  Ser Gln Pro 
    3605                 3610                 3615             


Met Leu  Leu Arg Val Val Gly  Ser Gln Thr Ser Asp  Ser Met Gly 
    3620                 3625                 3630             


Glu Glu  Asp Leu Leu Ser Pro  Pro Gln Asp Thr Ser  Thr Gly Leu 
    3635                 3640                 3645             


Glu Glu  Val Met Glu Gln Leu  Asn Asn Ser Phe Pro  Ser Ser Arg 
    3650                 3655                 3660             


Gly Arg  Asn Thr Pro Gly Lys  Pro Met Arg Glu Asp  Thr Met 
    3665                 3670                 3675         


<210>  3120
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMGDH__Homo_sapiens__NP_037523

<400>  3120

Met Leu Arg Pro Gly Ala Gln Leu Leu Arg Gly Leu Leu Leu Arg Ser 
1               5                   10                  15      


Cys Pro Leu Gln Gly Ser Pro Gly Arg Pro Arg Ser Val Cys Gly Arg 
            20                  25                  30          


Glu Gly Glu Glu Lys Pro Pro Leu Ser Ala Glu Thr Gln Trp Lys Asp 
        35                  40                  45              


Arg Ala Glu Thr Val Ile Ile Gly Gly Gly Cys Val Gly Val Ser Leu 
    50                  55                  60                  


Ala Tyr His Leu Ala Lys Ala Gly Met Lys Asp Val Val Leu Leu Glu 
65                  70                  75                  80  


Lys Ser Glu Leu Thr Ala Gly Ser Thr Trp His Ala Ala Gly Leu Thr 
                85                  90                  95      


Thr Tyr Phe His Pro Gly Ile Asn Leu Lys Lys Ile His Tyr Asp Ser 
            100                 105                 110         


Ile Lys Leu Tyr Glu Lys Leu Glu Glu Glu Thr Gly Gln Val Val Gly 
        115                 120                 125             


Phe His Gln Pro Gly Ser Ile Arg Leu Ala Thr Thr Pro Val Arg Val 
    130                 135                 140                 


Asp Glu Phe Lys Tyr Gln Met Thr Arg Thr Gly Trp His Ala Thr Glu 
145                 150                 155                 160 


Gln Tyr Leu Ile Glu Pro Glu Lys Ile Gln Glu Met Phe Pro Leu Leu 
                165                 170                 175     


Asn Met Asn Lys Val Leu Ala Gly Leu Tyr Asn Pro Gly Asp Gly His 
            180                 185                 190         


Ile Asp Pro Tyr Ser Leu Thr Met Ala Leu Ala Ala Gly Ala Arg Lys 
        195                 200                 205             


Cys Gly Ala Leu Leu Lys Tyr Pro Ala Pro Val Thr Ser Leu Lys Ala 
    210                 215                 220                 


Arg Ser Asp Gly Thr Trp Asp Val Glu Thr Pro Gln Gly Ser Met Arg 
225                 230                 235                 240 


Ala Asn Arg Ile Val Asn Ala Ala Gly Phe Trp Ala Arg Glu Val Gly 
                245                 250                 255     


Lys Met Ile Gly Leu Glu His Pro Leu Ile Pro Val Gln His Gln Tyr 
            260                 265                 270         


Val Val Thr Ser Thr Ile Ser Glu Val Lys Ala Leu Lys Arg Glu Leu 
        275                 280                 285             


Pro Val Leu Arg Asp Leu Glu Gly Ser Tyr Tyr Leu Arg Gln Glu Arg 
    290                 295                 300                 


Asp Gly Leu Leu Phe Gly Pro Tyr Glu Ser Gln Glu Lys Met Lys Val 
305                 310                 315                 320 


Gln Asp Ser Trp Val Thr Asn Gly Val Pro Pro Gly Phe Gly Lys Glu 
                325                 330                 335     


Leu Phe Glu Ser Asp Leu Asp Arg Ile Met Glu His Ile Lys Ala Ala 
            340                 345                 350         


Met Glu Met Val Pro Val Leu Lys Lys Ala Asp Ile Ile Asn Val Val 
        355                 360                 365             


Asn Gly Pro Ile Thr Tyr Ser Pro Asp Ile Leu Pro Met Val Gly Pro 
    370                 375                 380                 


His Gln Gly Val Arg Asn Tyr Trp Val Ala Ile Gly Phe Gly Tyr Gly 
385                 390                 395                 400 


Ile Ile His Ala Gly Gly Val Gly Lys Tyr Leu Ser Asp Trp Ile Leu 
                405                 410                 415     


His Gly Glu Pro Pro Phe Asp Leu Ile Glu Leu Asp Pro Asn Arg Tyr 
            420                 425                 430         


Gly Lys Trp Thr Thr Thr Gln Tyr Thr Glu Ala Lys Ala Arg Glu Ser 
        435                 440                 445             


Tyr Gly Phe Asn Asn Ile Val Gly Tyr Pro Lys Glu Glu Arg Phe Ala 
    450                 455                 460                 


Gly Arg Pro Thr Gln Arg Val Ser Gly Leu Tyr Gln Arg Leu Glu Ser 
465                 470                 475                 480 


Lys Cys Ser Met Gly Phe His Ala Gly Trp Glu Gln Pro His Trp Phe 
                485                 490                 495     


Tyr Lys Pro Gly Gln Asp Thr Gln Tyr Arg Pro Ser Phe Arg Arg Thr 
            500                 505                 510         


Asn Trp Phe Glu Pro Val Gly Ser Glu Tyr Lys Gln Val Met Gln Arg 
        515                 520                 525             


Val Ala Val Thr Asp Leu Ser Pro Phe Gly Lys Phe Asn Ile Lys Gly 
    530                 535                 540                 


Gln Asp Ser Ile Arg Leu Leu Asp His Leu Phe Ala Asn Val Ile Pro 
545                 550                 555                 560 


Lys Val Gly Phe Thr Asn Ile Ser His Met Leu Thr Pro Lys Gly Arg 
                565                 570                 575     


Val Tyr Ala Glu Leu Thr Val Ser His Gln Ser Pro Gly Glu Phe Leu 
            580                 585                 590         


Leu Ile Thr Gly Ser Gly Ser Glu Leu His Asp Leu Arg Trp Ile Glu 
        595                 600                 605             


Glu Glu Ala Val Lys Gly Gly Tyr Asp Val Glu Ile Lys Asn Ile Thr 
    610                 615                 620                 


Asp Glu Leu Gly Val Leu Gly Val Ala Gly Pro Gln Ala Arg Lys Val 
625                 630                 635                 640 


Leu Gln Lys Leu Thr Ser Glu Asp Leu Ser Asp Asp Val Phe Lys Phe 
                645                 650                 655     


Leu Gln Thr Lys Ser Leu Lys Val Ser Asn Ile Pro Val Thr Ala Ile 
            660                 665                 670         


Arg Ile Ser Tyr Thr Gly Glu Leu Gly Trp Glu Leu Tyr His Arg Arg 
        675                 680                 685             


Glu Asp Ser Val Ala Leu Tyr Asp Ala Ile Met Asn Ala Gly Gln Glu 
    690                 695                 700                 


Glu Gly Ile Asp Asn Phe Gly Thr Tyr Ala Met Asn Ala Leu Arg Leu 
705                 710                 715                 720 


Glu Lys Ala Phe Arg Ala Trp Gly Leu Glu Met Asn Cys Asp Thr Asn 
                725                 730                 735     


Pro Leu Glu Ala Gly Leu Glu Tyr Phe Val Lys Leu Asn Lys Pro Ala 
            740                 745                 750         


Asp Phe Ile Gly Lys Gln Ala Leu Lys Gln Ile Lys Ala Lys Gly Leu 
        755                 760                 765             


Lys Arg Arg Leu Val Cys Leu Thr Leu Ala Thr Asp Asp Val Asp Pro 
    770                 775                 780                 


Glu Gly Asn Glu Ser Ile Trp Tyr Asn Gly Lys Val Val Gly Asn Thr 
785                 790                 795                 800 


Thr Ser Gly Ser Tyr Ser Tyr Ser Ile Gln Lys Ser Leu Ala Phe Ala 
                805                 810                 815     


Tyr Val Pro Val Gln Leu Ser Glu Val Gly Gln Gln Val Glu Val Glu 
            820                 825                 830         


Leu Leu Gly Lys Asn Tyr Pro Ala Val Ile Ile Gln Glu Pro Leu Val 
        835                 840                 845             


Leu Thr Glu Pro Thr Arg Asn Arg Leu Gln Lys Lys Gly Gly Lys Asp 
    850                 855                 860                 


Lys Thr 
865     


<210>  3121
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMKN__Homo_sapiens__NP_001030593

<400>  3121

Met Asn Met Lys Pro Ala Thr Ala Ser Ala Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Gly Leu Ala Trp Thr Gln Gly Ser His Gly Trp Gly Ala Asp Ala Ser 
            20                  25                  30          


Ser Leu Gln Lys Arg Ala Gly Arg Ala Asp Gln Asn Tyr Asn Tyr Asn 
        35                  40                  45              


Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val Lys Thr 
    50                  55                  60                  


Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg Val Gln 
65                  70                  75                  80  


Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 
                85                  90  


<210>  3122
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMP1__Homo_sapiens__NP_001073380

<400>  3122

Met Lys Ile Ser Ile Leu Leu Met Phe Leu Trp Gly Leu Ser Cys Ala 
1               5                   10                  15      


Leu Pro Val Thr Arg Tyr Gln Asn Asn Glu Ser Glu Asp Ser Glu Glu 
            20                  25                  30          


Trp Lys Gly His Leu Ala Gln Ala Pro Thr Pro Pro Leu Ala Asn Glu 
        35                  40                  45              


Asp Pro Ser Asp Ser Thr Gln Ser Glu Glu Gly Leu Gly Ser Asp Asp 
    50                  55                  60                  


His Gln Tyr Ile Tyr Arg Leu Ala Gly Gly Phe Ser Arg Ser Thr Gly 
65                  70                  75                  80  


Lys Gly Gly Asp Asp Lys Asp Asp Asp Glu Asp Asp Ser Gly Asp Asp 
                85                  90                  95      


Thr Phe Gly Asp Asp Asp Ser Gly Pro Gly Pro Lys Asp Arg Gln Glu 
            100                 105                 110         


Gly Gly Asn Ser Arg Leu Gly Ser Asp Glu Asp Ser Asp Asp Thr Ile 
        115                 120                 125             


Gln Ala Ser Glu Glu Ser Ala Pro Gln Gly Gln Asp Ser Ala Gln Asp 
    130                 135                 140                 


Thr Thr Ser Glu Ser Arg Glu Leu Asp Asn Glu Asp Arg Val Asp Ser 
145                 150                 155                 160 


Lys Pro Glu Gly Gly Asp Ser Thr Gln Glu Ser Glu Ser Glu Glu His 
                165                 170                 175     


Trp Val Gly Gly Gly Ser Asp Gly Glu Ser Ser His Gly Asp Gly Ser 
            180                 185                 190         


Glu Leu Asp Asp Glu Gly Met Gln Ser Asp Asp Pro Glu Ser Ile Arg 
        195                 200                 205             


Ser Glu Arg Gly Asn Ser Arg Met Asn Ser Ala Gly Met Lys Ser Lys 
    210                 215                 220                 


Glu Ser Gly Glu Asn Ser Glu Gln Ala Asn Thr Gln Asp Ser Gly Gly 
225                 230                 235                 240 


Ser Gln Leu Leu Glu His Pro Ser Arg Lys Ile Phe Arg Lys Ser Arg 
                245                 250                 255     


Ile Ser Glu Glu Asp Asp Arg Ser Glu Leu Asp Asp Asn Asn Thr Met 
            260                 265                 270         


Glu Glu Val Lys Ser Asp Ser Thr Glu Asn Ser Asn Ser Arg Asp Thr 
        275                 280                 285             


Gly Leu Ser Gln Pro Arg Arg Asp Ser Lys Gly Asp Ser Gln Glu Asp 
    290                 295                 300                 


Ser Lys Glu Asn Leu Ser Gln Glu Glu Ser Gln Asn Val Asp Gly Pro 
305                 310                 315                 320 


Ser Ser Glu Ser Ser Gln Glu Ala Asn Leu Ser Ser Gln Glu Asn Ser 
                325                 330                 335     


Ser Glu Ser Gln Glu Glu Val Val Ser Glu Ser Arg Gly Asp Asn Pro 
            340                 345                 350         


Asp Pro Thr Thr Ser Tyr Val Glu Asp Gln Glu Asp Ser Asp Ser Ser 
        355                 360                 365             


Glu Glu Asp Ser Ser His Thr Leu Ser His Ser Lys Ser Glu Ser Arg 
    370                 375                 380                 


Glu Glu Gln Ala Asp Ser Glu Ser Ser Glu Ser Leu Asn Phe Ser Glu 
385                 390                 395                 400 


Glu Ser Pro Glu Ser Pro Glu Asp Glu Asn Ser Ser Ser Gln Glu Gly 
                405                 410                 415     


Leu Gln Ser His Ser Ser Ser Ala Glu Ser Gln Ser Glu Glu Ser His 
            420                 425                 430         


Ser Glu Glu Asp Asp Ser Asp Ser Gln Asp Ser Ser Arg Ser Lys Glu 
        435                 440                 445             


Asp Ser Asn Ser Thr Glu Ser Lys Ser Ser Ser Glu Glu Asp Gly Gln 
    450                 455                 460                 


Leu Lys Asn Ile Glu Ile Glu Ser Arg Lys Leu Thr Val Asp Ala Tyr 
465                 470                 475                 480 


His Asn Lys Pro Ile Gly Asp Gln Asp Asp Asn Asp Cys Gln Asp Gly 
                485                 490                 495     


Tyr 
    


<210>  3123
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMPK__Homo_sapiens__NP_001075029

<400>  3123

Met Ser Ala Glu Val Arg Leu Arg Arg Leu Gln Gln Leu Val Leu Asp 
1               5                   10                  15      


Pro Gly Phe Leu Gly Leu Glu Pro Leu Leu Asp Leu Leu Leu Gly Val 
            20                  25                  30          


His Gln Glu Leu Gly Ala Ser Glu Leu Ala Gln Asp Lys Tyr Val Ala 
        35                  40                  45              


Asp Phe Leu Gln Trp Ala Glu Pro Ile Val Val Arg Leu Lys Glu Val 
    50                  55                  60                  


Arg Leu Gln Arg Asp Asp Phe Glu Ile Leu Lys Val Ile Gly Arg Gly 
65                  70                  75                  80  


Ala Phe Ser Glu Val Ala Val Val Lys Met Lys Gln Thr Gly Gln Val 
                85                  90                  95      


Tyr Ala Met Lys Ile Met Asn Lys Trp Asp Met Leu Lys Arg Gly Glu 
            100                 105                 110         


Val Ser Cys Phe Arg Glu Glu Arg Asp Val Leu Val Asn Gly Asp Arg 
        115                 120                 125             


Arg Trp Ile Thr Gln Leu His Phe Ala Phe Gln Asp Glu Asn Tyr Leu 
    130                 135                 140                 


Tyr Leu Val Met Glu Tyr Tyr Val Gly Gly Asp Leu Leu Thr Leu Leu 
145                 150                 155                 160 


Ser Lys Phe Gly Glu Arg Ile Pro Ala Glu Met Ala Arg Phe Tyr Leu 
                165                 170                 175     


Ala Glu Ile Val Met Ala Ile Asp Ser Val His Arg Leu Gly Tyr Val 
            180                 185                 190         


His Arg Asp Ile Lys Pro Asp Asn Ile Leu Leu Asp Arg Cys Gly His 
        195                 200                 205             


Ile Arg Leu Ala Asp Phe Gly Ser Cys Leu Lys Leu Arg Ala Asp Gly 
    210                 215                 220                 


Thr Val Arg Ser Leu Val Ala Val Gly Thr Pro Asp Tyr Leu Ser Pro 
225                 230                 235                 240 


Glu Ile Leu Gln Ala Val Gly Gly Gly Pro Gly Thr Gly Ser Tyr Gly 
                245                 250                 255     


Pro Glu Cys Asp Trp Trp Ala Leu Gly Val Phe Ala Tyr Glu Met Phe 
            260                 265                 270         


Tyr Gly Gln Thr Pro Phe Tyr Ala Asp Ser Thr Ala Glu Thr Tyr Gly 
        275                 280                 285             


Lys Ile Val His Tyr Lys Glu His Leu Ser Leu Pro Leu Val Asp Glu 
    290                 295                 300                 


Gly Val Pro Glu Glu Ala Arg Asp Phe Ile Gln Arg Leu Leu Cys Pro 
305                 310                 315                 320 


Pro Glu Thr Arg Leu Gly Arg Gly Gly Ala Gly Asp Phe Arg Thr His 
                325                 330                 335     


Pro Phe Phe Phe Gly Leu Asp Trp Asp Gly Leu Arg Asp Ser Val Pro 
            340                 345                 350         


Pro Phe Thr Pro Asp Phe Glu Gly Ala Thr Asp Thr Cys Asn Phe Asp 
        355                 360                 365             


Leu Val Glu Asp Gly Leu Thr Ala Met Glu Thr Leu Ser Asp Ile Arg 
    370                 375                 380                 


Glu Gly Ala Pro Leu Gly Val His Leu Pro Phe Val Gly Tyr Ser Tyr 
385                 390                 395                 400 


Ser Cys Met Ala Leu Arg Asp Ser Glu Val Pro Gly Pro Thr Pro Met 
                405                 410                 415     


Glu Leu Glu Ala Glu Gln Leu Leu Glu Pro His Val Gln Ala Pro Ser 
            420                 425                 430         


Leu Glu Pro Ser Val Ser Pro Gln Asp Glu Thr Ala Glu Val Ala Val 
        435                 440                 445             


Pro Ala Ala Val Pro Ala Ala Glu Ala Glu Ala Glu Val Thr Leu Arg 
    450                 455                 460                 


Glu Leu Gln Glu Ala Leu Glu Glu Glu Val Leu Thr Arg Gln Ser Leu 
465                 470                 475                 480 


Ser Arg Glu Met Glu Ala Ile Arg Thr Asp Asn Gln Asn Phe Ala Ser 
                485                 490                 495     


Gln Leu Arg Glu Ala Glu Ala Arg Asn Arg Asp Leu Glu Ala His Val 
            500                 505                 510         


Arg Gln Leu Gln Glu Arg Met Glu Leu Leu Gln Ala Glu Gly Ala Thr 
        515                 520                 525             


Ala Val Thr Gly Val Pro Ser Pro Arg Ala Thr Asp Pro Pro Ser His 
    530                 535                 540                 


Leu Asp Gly Pro Pro Ala Val Ala Val Gly Gln Cys Pro Leu Val Gly 
545                 550                 555                 560 


Pro Gly Pro Met His Arg Arg His Leu Leu Leu Pro Ala Arg Val Pro 
                565                 570                 575     


Arg Pro Gly Leu Ser Glu Ala Leu Ser Leu Leu Leu Phe Ala Val Val 
            580                 585                 590         


Leu Ser Arg Ala Ala Ala Leu Gly Cys Ile Gly Leu Val Ala His Ala 
        595                 600                 605             


Gly Gln Leu Thr Ala Val Trp Arg Arg Pro Gly Ala Ala Arg Ala Pro 
    610                 615                 620                 


<210>  3124
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMRT1__Homo_sapiens__NP_068770

<400>  3124

Met Pro Asn Asp Glu Ala Phe Ser Lys Pro Ser Thr Pro Ser Glu Ala 
1               5                   10                  15      


Pro His Ala Pro Gly Val Pro Pro Gln Gly Arg Ala Gly Gly Phe Gly 
            20                  25                  30          


Lys Ala Ser Gly Ala Leu Val Gly Ala Ala Ser Gly Ser Ser Ala Gly 
        35                  40                  45              


Gly Ser Ser Arg Gly Gly Gly Ser Gly Ser Gly Ala Ser Asp Leu Gly 
    50                  55                  60                  


Ala Gly Ser Lys Lys Ser Pro Arg Leu Pro Lys Cys Ala Arg Cys Arg 
65                  70                  75                  80  


Asn His Gly Tyr Ala Ser Pro Leu Lys Gly His Lys Arg Phe Cys Met 
                85                  90                  95      


Trp Arg Asp Cys Gln Cys Lys Lys Cys Asn Leu Ile Ala Glu Arg Gln 
            100                 105                 110         


Arg Val Met Ala Ala Gln Val Ala Leu Arg Arg Gln Gln Ala Gln Glu 
        115                 120                 125             


Glu Glu Leu Gly Ile Ser His Pro Ile Pro Leu Pro Ser Ala Ala Glu 
    130                 135                 140                 


Leu Leu Val Lys Arg Glu Asn Asn Gly Ser Asn Pro Cys Leu Met Thr 
145                 150                 155                 160 


Glu Cys Ser Gly Thr Ser Gln Pro Pro Pro Ala Ser Val Pro Thr Thr 
                165                 170                 175     


Ala Ala Ser Glu Gly Arg Met Val Ile Gln Asp Ile Pro Ala Val Thr 
            180                 185                 190         


Ser Arg Gly His Val Glu Asn Thr Pro Asp Leu Val Ser Asp Ser Thr 
        195                 200                 205             


Tyr Tyr Ser Ser Phe Tyr Gln Pro Ser Leu Phe Pro Tyr Tyr Asn Asn 
    210                 215                 220                 


Leu Tyr Asn Cys Pro Gln Tyr Ser Met Ala Leu Ala Ala Asp Ser Ala 
225                 230                 235                 240 


Ser Gly Glu Val Gly Asn Pro Leu Gly Gly Ser Pro Val Lys Asn Ser 
                245                 250                 255     


Leu Arg Gly Leu Pro Gly Pro Tyr Val Pro Gly Gln Thr Gly Asn Gln 
            260                 265                 270         


Trp Gln Met Lys Asn Met Glu Asn Arg His Ala Met Ser Ser Gln Tyr 
        275                 280                 285             


Arg Met His Ser Tyr Tyr Pro Pro Pro Ser Tyr Leu Gly Gln Ser Val 
    290                 295                 300                 


Pro Gln Phe Phe Thr Phe Glu Asp Ala Pro Ser Tyr Pro Glu Ala Arg 
305                 310                 315                 320 


Ala Ser Val Phe Ser Pro Pro Ser Ser Gln Asp Ser Gly Leu Val Ser 
                325                 330                 335     


Leu Ser Ser Ser Ser Pro Ile Ser Asn Lys Ser Thr Lys Ala Val Leu 
            340                 345                 350         


Glu Cys Glu Pro Ala Ser Glu Pro Ser Ser Phe Thr Val Thr Pro Val 
        355                 360                 365             


Ile Glu Glu Asp Glu 
    370             


<210>  3125
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMRT2__Homo_sapiens__XP_006716781

<400>  3125

Met Asp Lys Lys Gly Leu Ser Gly Lys Gln Asn Asn Phe Glu Arg Lys 
1               5                   10                  15      


Ala Val Tyr Gln Arg Gln Val Arg Ala Pro Ser Leu Leu Ala Lys Ser 
            20                  25                  30          


Ile Leu Glu Gly Tyr Arg Pro Ile Pro Ala Glu Thr Tyr Val Gly Gly 
        35                  40                  45              


Thr Phe Pro Leu Pro Pro Pro Val Ser Asp Arg Met Arg Lys Arg Arg 
    50                  55                  60                  


Ala Phe Ala Asp Lys Glu Leu Glu Asn Ile Met Leu Glu Arg Glu Tyr 
65                  70                  75                  80  


Lys Glu Arg Glu Met Leu Glu Thr Ser Gln Ala Ala Ala Leu Phe Leu 
                85                  90                  95      


Pro Asn Arg Met Val Pro Gly Pro Asp Tyr Asn Ser Tyr Lys Ser Ala 
            100                 105                 110         


Tyr Ser Pro Ser Pro Val Glu Pro Pro Ser Lys Asp Phe Cys Asn Phe 
        115                 120                 125             


Leu Pro Thr Cys Leu Asp Leu Thr Met Gln Tyr Ser Gly Ser Gly Asn 
    130                 135                 140                 


Met Glu Leu Ile Ser Ser Asn Val Ser Val Ala Thr Thr Tyr Arg Gln 
145                 150                 155                 160 


Tyr Pro Leu Ser Ser Arg Phe Leu Val Trp Pro Lys Cys Gly Pro Ile 
                165                 170                 175     


Ser Asp Thr Leu Leu Tyr Gln Gln Cys Leu Leu Asn Ala Thr Thr Ser 
            180                 185                 190         


Val Gln Ala Leu Lys Pro Gly Ala Ser Trp Asp Leu Lys Gly Ala Arg 
        195                 200                 205             


Val Gln Asp Gly Leu Ser Ala Glu Gln Asp Met Met Pro Ser Lys Leu 
    210                 215                 220                 


Glu Gly Ser Leu Val Leu Pro His Thr Pro Glu Ile Gln Thr Thr Arg 
225                 230                 235                 240 


Ser Asp Leu Gln Gly His Gln Ala Val Pro Glu Arg Ser Ala Phe Ser 
                245                 250                 255     


Pro Pro Arg Arg Asn Phe Ser Pro Ile Val Asp Thr Asp Ser Leu Ala 
            260                 265                 270         


Ala Gln Gly His Val Leu Thr Lys Ile Ser Lys Glu Asn Thr Arg His 
        275                 280                 285             


Pro Leu Pro Leu Arg His Asn Pro Phe His Ser Leu Phe Gln Gln Thr 
    290                 295                 300                 


Leu Thr Asp Lys Ser Gly Pro Glu Leu Lys Thr Pro Phe Val Lys Glu 
305                 310                 315                 320 


Ala Phe Glu Glu Thr Pro Lys Lys His Arg Glu Cys Leu Val Lys Asp 
                325                 330                 335     


Asn Gln Lys Tyr Thr Phe Thr Ile Asp Arg Cys Ala Lys Asp Leu Phe 
            340                 345                 350         


Val Ala Lys Gln Val Gly Thr Lys Leu Ser Val Asn Glu Pro Leu Ser 
        355                 360                 365             


Phe Ser Val Glu Ser Ile Leu Lys Arg Pro Ser Ser Ala Ile Thr Arg 
    370                 375                 380                 


Val Ser Gln 
385         


<210>  3126
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMRT3__Homo_sapiens__NP_067063

<400>  3126

Met Asn Gly Tyr Gly Ser Pro Tyr Leu Tyr Met Gly Gly Pro Val Ser 
1               5                   10                  15      


Gln Pro Pro Arg Ala Pro Leu Gln Arg Thr Pro Lys Cys Ala Arg Cys 
            20                  25                  30          


Arg Asn His Gly Val Leu Ser Trp Leu Lys Gly His Lys Arg Tyr Cys 
        35                  40                  45              


Arg Phe Lys Asp Cys Thr Cys Glu Lys Cys Ile Leu Ile Ile Glu Arg 
    50                  55                  60                  


Gln Arg Val Met Ala Ala Gln Val Ala Leu Arg Arg Gln Gln Ala Asn 
65                  70                  75                  80  


Glu Ser Leu Glu Ser Leu Ile Pro Asp Ser Leu Arg Ala Leu Pro Gly 
                85                  90                  95      


Pro Pro Pro Pro Gly Asp Ala Val Ala Ala Pro Gln Pro Pro Pro Ala 
            100                 105                 110         


Ser Gln Pro Ser Gln Pro Gln Pro Pro Arg Pro Ala Ala Glu Leu Ala 
        115                 120                 125             


Ala Ala Ala Ala Leu Arg Trp Thr Ala Glu Pro Gln Pro Gly Ala Leu 
    130                 135                 140                 


Gln Ala Gln Leu Ala Lys Pro Asp Leu Thr Glu Glu Arg Leu Gly Asp 
145                 150                 155                 160 


Gly Lys Ser Ala Asp Asn Thr Glu Val Phe Ser Asp Lys Asp Thr Asp 
                165                 170                 175     


Gln Arg Ser Ser Pro Asp Val Ala Lys Ser Lys Gly Cys Phe Thr Pro 
            180                 185                 190         


Glu Ser Pro Glu Ile Val Ser Val Glu Glu Gly Gly Tyr Ala Val Gln 
        195                 200                 205             


Lys Asn Gly Gly Asn Pro Glu Ser Arg Pro Asp Ser Pro Lys Cys His 
    210                 215                 220                 


Ala Glu Gln Asn His Leu Leu Ile Glu Gly Pro Ser Gly Thr Val Ser 
225                 230                 235                 240 


Leu Pro Phe Ser Leu Lys Ala Asn Arg Pro Pro Leu Glu Val Leu Lys 
                245                 250                 255     


Lys Ile Phe Pro Asn Gln Lys Pro Thr Val Leu Glu Leu Ile Leu Lys 
            260                 265                 270         


Gly Cys Gly Gly Asp Leu Val Ser Ala Val Glu Val Leu Leu Ser Ser 
        275                 280                 285             


Arg Ser Ser Val Thr Gly Ala Glu Arg Thr Ser Ala Glu Pro Glu Ser 
    290                 295                 300                 


Leu Ala Leu Pro Ser Asn Gly His Ile Phe Glu His Thr Leu Ser Ser 
305                 310                 315                 320 


Tyr Pro Ile Ser Ser Ser Lys Trp Ser Val Gly Ser Ala Phe Arg Val 
                325                 330                 335     


Pro Asp Thr Leu Arg Phe Ser Ala Asp Ser Ser Asn Val Val Pro Ser 
            340                 345                 350         


Pro Leu Ala Gly Pro Leu Gln Pro Pro Phe Pro Gln Pro Pro Arg Tyr 
        355                 360                 365             


Pro Leu Met Leu Arg Asn Thr Leu Ala Arg Ser Gln Ser Ser Pro Phe 
    370                 375                 380                 


Leu Pro Asn Asp Val Thr Leu Trp Asn Thr Met Thr Leu Gln Gln Gln 
385                 390                 395                 400 


Tyr Gln Leu Arg Ser Gln Tyr Val Ser Pro Phe Pro Ser Asn Ser Thr 
                405                 410                 415     


Ser Val Phe Arg Ser Ser Pro Val Leu Pro Ala Arg Ala Thr Glu Asp 
            420                 425                 430         


Pro Arg Ile Ser Ile Pro Asp Asp Gly Cys Pro Phe Val Ser Lys Gln 
        435                 440                 445             


Ser Ile Tyr Thr Glu Asp Asp Tyr Asp Glu Arg Ser Asp Ser Ser Asp 
    450                 455                 460                 


Ser Arg Thr Leu Asn Thr Ser Ser 
465                 470         


<210>  3127
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMRTA1__Homo_sapiens__NP_071443

<400>  3127

Met Glu Arg Ser Gln Cys Gly Ser Arg Asp Arg Gly Val Ser Gly Arg 
1               5                   10                  15      


Pro His Leu Ala Pro Gly Leu Val Val Ala Ala Pro Pro Pro Pro Ser 
            20                  25                  30          


Pro Ala Leu Pro Val Pro Ser Gly Met Gln Val Pro Pro Ala Phe Leu 
        35                  40                  45              


Arg Pro Pro Ser Leu Phe Leu Arg Ala Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Thr Ser Gly Ser Gly Gly Cys Pro Pro Ala Pro Gly Leu 
65                  70                  75                  80  


Glu Ser Gly Val Gly Ala Val Gly Cys Gly Tyr Pro Arg Thr Pro Lys 
                85                  90                  95      


Cys Ala Arg Cys Arg Asn His Gly Val Val Ser Ala Leu Lys Gly His 
            100                 105                 110         


Lys Arg Phe Cys Arg Trp Arg Asp Cys Ala Cys Ala Lys Cys Thr Leu 
        115                 120                 125             


Ile Ala Glu Arg Gln Arg Val Met Ala Ala Gln Val Ala Leu Arg Arg 
    130                 135                 140                 


Gln Gln Ala Gln Glu Glu Ser Glu Ala Arg Gly Leu Gln Arg Leu Leu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Trp Pro Pro Gly Gly Arg Ala Ser Gly Gly Gly 
                165                 170                 175     


Gly Arg Ala Glu Asn Pro Gln Ser Thr Gly Gly Pro Ala Ala Gly Ala 
            180                 185                 190         


Ala Leu Gly Leu Gly Ala Leu Arg Gln Ala Ser Gly Ser Ala Thr Pro 
        195                 200                 205             


Ala Phe Glu Val Phe Gln Gln Asp Tyr Pro Glu Glu Lys Gln Glu Gln 
    210                 215                 220                 


Lys Glu Ser Lys Cys Glu Ser Cys Gln Asn Gly Gln Glu Glu Leu Ile 
225                 230                 235                 240 


Ser Lys Ser His Gln Leu Tyr Leu Gly Ser Ser Ser Arg Ser Asn Gly 
                245                 250                 255     


Val Ile Gly Lys Gln Ser Ile Gly Ser Ser Ile Ser Glu Tyr Ser Asn 
            260                 265                 270         


Lys Pro Asp Ser Ile Leu Ser Pro His Pro Gly Glu Gln Ser Gly Gly 
        275                 280                 285             


Glu Glu Ser Pro Arg Ser Leu Ser Ser Ser Asp Leu Glu Ser Gly Asn 
    290                 295                 300                 


Glu Ser Glu Trp Val Lys Asp Leu Thr Ala Thr Lys Ala Ser Leu Pro 
305                 310                 315                 320 


Thr Val Ser Ser Arg Pro Arg Asp Pro Leu Asp Ile Leu Thr Lys Ile 
                325                 330                 335     


Phe Pro Asn Tyr Arg Arg Ser Arg Leu Glu Gly Ile Leu Arg Phe Cys 
            340                 345                 350         


Lys Gly Asp Val Val Gln Ala Ile Glu Gln Val Leu Asn Gly Lys Glu 
        355                 360                 365             


His Lys Pro Asp Asn Arg Asn Leu Ala Asn Ser Glu Glu Leu Glu Asn 
    370                 375                 380                 


Thr Ala Phe Gln Arg Ala Ser Ser Phe Ser Leu Ala Gly Ile Gly Phe 
385                 390                 395                 400 


Gly Thr Leu Gly Asn Lys Ser Ala Phe Ser Pro Leu Gln Thr Thr Ser 
                405                 410                 415     


Ala Ser Tyr Gly Gly Asp Ser Ser Leu Tyr Gly Val Asn Pro Arg Val 
            420                 425                 430         


Gly Ile Ser Pro Leu Arg Leu Ala Tyr Ser Ser Ala Gly Arg Gly Leu 
        435                 440                 445             


Ser Gly Phe Met Ser Pro Tyr Leu Thr Pro Gly Leu Val Pro Thr Leu 
    450                 455                 460                 


Pro Phe Arg Pro Ala Leu Asp Tyr Ala Phe Ser Gly Met Ile Arg Asp 
465                 470                 475                 480 


Ser Ser Tyr Leu Ser Ser Lys Asp Ser Ile Thr Cys Gly Arg Leu Tyr 
                485                 490                 495     


Phe Arg Pro Asn Gln Asp Asn Pro 
            500                 


<210>  3128
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMTF1__Homo_sapiens__NP_001135798

<400>  3128

Met Thr Ala Thr Thr Glu Val Ala Asp Asp Glu Val Thr Glu Gly Thr 
1               5                   10                  15      


Val Thr Gln Ile Gln Ile Leu Gln Asn Glu Gln Leu Asp Glu Ile Ser 
            20                  25                  30          


Pro Leu Gly Asn Glu Glu Val Ser Ala Val Ser Gln Ala Trp Phe Thr 
        35                  40                  45              


Thr Lys Glu Asp Lys Asp Ser Leu Thr Asn Lys Gly His Lys Trp Lys 
    50                  55                  60                  


Gln Gly Met Trp Ser Lys Glu Glu Ile Asp Ile Leu Met Asn Asn Ile 
65                  70                  75                  80  


Glu Arg Tyr Leu Lys Ala Arg Gly Ile Lys Asp Ala Thr Glu Ile Ile 
                85                  90                  95      


Phe Glu Met Ser Lys Asp Glu Arg Lys Asp Phe Tyr Arg Thr Ile Ala 
            100                 105                 110         


Trp Gly Leu Asn Arg Pro Leu Phe Ala Val Tyr Arg Arg Val Leu Arg 
        115                 120                 125             


Met Tyr Asp Asp Arg Asn His Val Gly Lys Tyr Thr Pro Glu Glu Ile 
    130                 135                 140                 


Glu Lys Leu Lys Glu Leu Arg Ile Lys His Gly Asn Asp Trp Ala Thr 
145                 150                 155                 160 


Ile Gly Ala Ala Leu Gly Arg Ser Ala Ser Ser Val Lys Asp Arg Cys 
                165                 170                 175     


Arg Leu Met Lys Asp Thr Cys Asn Thr Gly Lys Trp Thr Glu Glu Glu 
            180                 185                 190         


Glu Lys Arg Leu Ala Glu Val Val His Glu Leu Thr Ser Thr Glu Pro 
        195                 200                 205             


Gly Asp Ile Val Thr Gln Gly Val Ser Trp Ala Ala Val Ala Glu Arg 
    210                 215                 220                 


Val Gly Thr Arg Ser Glu Lys Gln Cys Arg Ser Lys Trp Leu Asn Tyr 
225                 230                 235                 240 


Leu Asn Trp Lys Gln Ser Gly Gly Thr Glu Trp Thr Lys Glu Asp Glu 
                245                 250                 255     


Ile Asn Leu Ile Leu Arg Ile Ala Glu Leu Asp Val Ala Asp Glu Asn 
            260                 265                 270         


Asp Ile Asn Trp Asp Leu Leu Ala Glu Gly Trp Ser Ser Val Arg Ser 
        275                 280                 285             


Pro Gln Trp Leu Arg Ser Lys Trp Trp Thr Ile Lys Arg Gln Ile Ala 
    290                 295                 300                 


Asn His Lys Asp Val Ser Phe Pro Val Leu Ile Lys Gly Leu Lys Gln 
305                 310                 315                 320 


Leu His Glu Asn Gln Lys Asn Asn Pro Thr Leu Leu Glu Asn Lys Ser 
                325                 330                 335     


Gly Ser Gly Val Pro Asn Ser Asn Thr Asn Ser Ser Val Gln His Val 
            340                 345                 350         


Gln Ile Arg Val Ala Arg Leu Glu Asp Asn Thr Ala Ile Ser Ser Ser 
        355                 360                 365             


Pro Met Ala Ala Leu Gln Ile Pro Val Gln Ile Thr His Val Ser Ser 
    370                 375                 380                 


Ala Asp Ser Pro Ala Thr Val Asp Ser Glu Thr Ile Thr Leu Asn Ser 
385                 390                 395                 400 


Gly Thr Leu Gln Thr Phe Glu Ile Leu Pro Ser Phe His Leu Gln Pro 
                405                 410                 415     


Thr Gly Thr Pro Gly Thr Tyr Leu Leu Gln Thr Ser Ser Ser Gln Gly 
            420                 425                 430         


Leu Pro Leu Thr Leu Thr Ala Ser Pro Thr Val Thr Leu Thr Ala Ala 
        435                 440                 445             


Ala Pro Ala Ser Pro Glu Gln Ile Ile Val His Ala Leu Ser Pro Glu 
    450                 455                 460                 


His Leu Leu Asn Thr Ser Asp Asn Val Thr Val Gln Cys His Thr Pro 
465                 470                 475                 480 


Arg Val Ile Ile Gln Thr Val Ala Thr Glu Asp Ile Thr Ser Ser Ile 
                485                 490                 495     


Ser Gln Ala Glu Leu Thr Val Asp Ser Asp Ile Gln Ser Ser Asp Phe 
            500                 505                 510         


Pro Glu Pro Pro Asp Ala Leu Glu Ala Asp Thr Phe Pro Asp Glu Ile 
        515                 520                 525             


His His Pro Lys Met Thr Val Glu Pro Ser Phe Asn Asp Ala His Val 
    530                 535                 540                 


Ser Lys Phe Ser Asp Gln Asn Ser Thr Glu Leu Met Asn Ser Val Met 
545                 550                 555                 560 


Val Arg Thr Glu Glu Glu Ile Ser Asp Thr Asp Leu Lys Gln Glu Glu 
                565                 570                 575     


Ser Pro Ser Asp Leu Ala Ser Ala Tyr Val Thr Glu Gly Leu Glu Ser 
            580                 585                 590         


Pro Thr Ile Glu Glu Gln Val Asp Gln Thr Ile Asp Asp Glu Thr Ile 
        595                 600                 605             


Leu Ile Val Pro Ser Pro His Gly Phe Ile Gln Ala Ser Asp Val Ile 
    610                 615                 620                 


Asp Thr Glu Ser Val Leu Pro Leu Thr Thr Leu Thr Asp Pro Ile Leu 
625                 630                 635                 640 


Gln His His Gln Glu Glu Ser Asn Ile Ile Gly Ser Ser Leu Gly Ser 
                645                 650                 655     


Pro Val Ser Glu Asp Ser Lys Asp Val Glu Asp Leu Val Asn Cys His 
            660                 665                 670         


<210>  3129
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMTN__Homo_sapiens__NP_001107611

<400>  3129

Met Glu Arg Leu Gln Lys Ala Lys Met Asp Asn Gln Val Leu Gly Tyr 
1               5                   10                  15      


Lys Asp Leu Ala Ala Ile Pro Lys Asp Lys Ala Ile Leu Asp Ile Glu 
            20                  25                  30          


Arg Pro Asp Leu Met Ile Tyr Glu Pro His Phe Thr Tyr Ser Leu Leu 
        35                  40                  45              


Glu His Val Glu Leu Pro Arg Ser Arg Glu Arg Ser Leu Ser Pro Lys 
    50                  55                  60                  


Ser Thr Ser Pro Pro Pro Ser Pro Glu Val Trp Ala Asp Ser Arg Ser 
65                  70                  75                  80  


Pro Gly Ile Ile Ser Gln Ala Ser Ala Pro Arg Thr Thr Gly Thr Pro 
                85                  90                  95      


Arg Thr Ser Leu Pro His Phe His His Pro Glu Thr Ser Arg Pro Asp 
            100                 105                 110         


Ser Asn Ile Tyr Lys Lys Pro Pro Ile Tyr Lys Gln Arg Glu Ser Val 
        115                 120                 125             


Gly Gly Ser Pro Gln Thr Lys His Leu Ile Glu Asp Leu Ile Ile Glu 
    130                 135                 140                 


Ser Ser Lys Phe Pro Ala Ala Gln Pro Pro Asp Pro Asn Gln Pro Ala 
145                 150                 155                 160 


Lys Ile Glu Thr Asp Tyr Trp Pro Cys Pro Pro Ser Leu Ala Val Val 
                165                 170                 175     


Glu Thr Glu Trp Arg Lys Arg Lys Ala Ser Arg Arg Gly Ala Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Asp Asp Asp Ser Gly Glu Glu Met Lys Ala Leu 
        195                 200                 205             


Arg Glu Arg Gln Arg Glu Glu Leu Ser Lys Val Thr Ser Asn Leu Gly 
    210                 215                 220                 


Lys Met Ile Leu Lys Glu Glu Met Glu Lys Ser Leu Pro Ile Arg Arg 
225                 230                 235                 240 


Lys Thr Arg Ser Leu Pro Asp Arg Thr Pro Phe His Thr Ser Leu His 
                245                 250                 255     


Gln Gly Thr Ser Lys Ser Ser Ser Leu Pro Ala Tyr Gly Arg Thr Thr 
            260                 265                 270         


Leu Ser Arg Leu Gln Ser Thr Glu Phe Ser Pro Ser Gly Ser Glu Thr 
        275                 280                 285             


Gly Ser Pro Gly Leu Gln Ile Tyr Pro Tyr Glu Met Leu Val Val Thr 
    290                 295                 300                 


Asn Lys Gly Arg Thr Lys Leu Pro Pro Gly Val Asp Arg Met Arg Leu 
305                 310                 315                 320 


Glu Arg His Leu Ser Ala Glu Asp Phe Ser Arg Val Phe Ala Met Ser 
                325                 330                 335     


Pro Glu Glu Phe Gly Lys Leu Ala Leu Trp Lys Arg Asn Glu Leu Lys 
            340                 345                 350         


Lys Lys Ala Ser Leu Phe 
        355             


<210>  3130
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMWD__Homo_sapiens__NP_004934

<400>  3130

Met Ala Ala Gly Gly Ala Glu Gly Gly Ser Gly Pro Gly Ala Ala Met 
1               5                   10                  15      


Gly Asp Cys Ala Glu Ile Lys Ser Gln Phe Arg Thr Arg Glu Gly Phe 
            20                  25                  30          


Tyr Lys Leu Leu Pro Gly Asp Gly Ala Ala Arg Arg Ser Gly Pro Ala 
        35                  40                  45              


Ser Ala Gln Thr Pro Val Pro Pro Gln Pro Pro Gln Pro Pro Pro Gly 
    50                  55                  60                  


Pro Ala Ser Ala Ser Gly Pro Gly Ala Ala Gly Pro Ala Ser Ser Pro 
65                  70                  75                  80  


Pro Pro Ala Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala Val Arg Leu 
                85                  90                  95      


Ser Leu Val Arg Leu Gly Glu Pro Asp Ser Ala Gly Ala Gly Glu Pro 
            100                 105                 110         


Pro Ala Thr Pro Ala Gly Leu Gly Ser Gly Gly Asp Arg Val Cys Phe 
        115                 120                 125             


Asn Leu Gly Arg Glu Leu Tyr Phe Tyr Pro Gly Cys Cys Arg Arg Gly 
    130                 135                 140                 


Ser Gln Arg Ser Ile Asp Leu Asn Lys Pro Ile Asp Lys Arg Ile Tyr 
145                 150                 155                 160 


Lys Gly Thr Gln Pro Thr Cys His Asp Phe Asn Gln Phe Thr Ala Ala 
                165                 170                 175     


Thr Glu Thr Ile Ser Leu Leu Val Gly Phe Ser Ala Gly Gln Val Gln 
            180                 185                 190         


Tyr Leu Asp Leu Ile Lys Lys Asp Thr Ser Lys Leu Phe Asn Glu Glu 
        195                 200                 205             


Arg Leu Ile Asp Lys Thr Lys Val Thr Tyr Leu Lys Trp Leu Pro Glu 
    210                 215                 220                 


Ser Glu Ser Leu Phe Leu Ala Ser His Ala Ser Gly His Leu Tyr Leu 
225                 230                 235                 240 


Tyr Asn Val Ser His Pro Cys Ala Ser Ala Pro Pro Gln Tyr Ser Leu 
                245                 250                 255     


Leu Lys Gln Gly Glu Gly Phe Ser Val Tyr Ala Ala Lys Ser Lys Ala 
            260                 265                 270         


Pro Arg Asn Pro Leu Ala Lys Trp Ala Val Gly Glu Gly Pro Leu Asn 
        275                 280                 285             


Glu Phe Ala Phe Ser Pro Asp Gly Arg His Leu Ala Cys Val Ser Gln 
    290                 295                 300                 


Asp Gly Cys Leu Arg Val Phe His Phe Asp Ser Met Leu Leu Arg Gly 
305                 310                 315                 320 


Leu Met Lys Ser Tyr Phe Gly Gly Leu Leu Cys Val Cys Trp Ser Pro 
                325                 330                 335     


Asp Gly Arg Tyr Val Val Thr Gly Gly Glu Asp Asp Leu Val Thr Val 
            340                 345                 350         


Trp Ser Phe Thr Glu Gly Arg Val Val Ala Arg Gly His Gly His Lys 
        355                 360                 365             


Ser Trp Val Asn Ala Val Ala Phe Asp Pro Tyr Thr Thr Arg Ala Glu 
    370                 375                 380                 


Glu Ala Ala Thr Ala Ala Gly Ala Asp Gly Glu Arg Ser Gly Glu Glu 
385                 390                 395                 400 


Glu Glu Glu Glu Pro Glu Ala Ala Gly Thr Gly Ser Ala Gly Gly Ala 
                405                 410                 415     


Pro Leu Ser Pro Leu Pro Lys Ala Gly Ser Ile Thr Tyr Arg Phe Gly 
            420                 425                 430         


Ser Ala Gly Gln Asp Thr Gln Phe Cys Leu Trp Asp Leu Thr Glu Asp 
        435                 440                 445             


Val Leu Tyr Pro His Pro Pro Leu Ala Arg Thr Arg Thr Leu Pro Gly 
    450                 455                 460                 


Thr Pro Gly Thr Thr Pro Pro Ala Ala Ser Ser Ser Arg Gly Gly Glu 
465                 470                 475                 480 


Pro Gly Pro Gly Pro Leu Pro Arg Ser Leu Ser Arg Ser Asn Ser Leu 
                485                 490                 495     


Pro His Pro Ala Gly Gly Gly Lys Ala Gly Gly Pro Gly Val Ala Ala 
            500                 505                 510         


Glu Pro Gly Thr Pro Phe Ser Ile Gly Arg Phe Ala Thr Leu Thr Leu 
        515                 520                 525             


Gln Glu Arg Arg Asp Arg Gly Ala Glu Lys Glu His Lys Arg Tyr His 
    530                 535                 540                 


Ser Leu Gly Asn Ile Ser Arg Gly Gly Ser Gly Gly Ser Gly Ser Gly 
545                 550                 555                 560 


Gly Glu Lys Pro Ser Gly Pro Val Pro Arg Ser Arg Leu Asp Pro Ala 
                565                 570                 575     


Lys Val Leu Gly Thr Ala Leu Cys Pro Arg Ile His Glu Val Pro Leu 
            580                 585                 590         


Leu Glu Pro Leu Val Cys Lys Lys Ile Ala Gln Glu Arg Leu Thr Val 
        595                 600                 605             


Leu Leu Phe Leu Glu Asp Cys Ile Ile Thr Ala Cys Gln Glu Gly Leu 
    610                 615                 620                 


Ile Cys Thr Trp Ala Arg Pro Gly Lys Ala Phe Thr Asp Glu Glu Thr 
625                 630                 635                 640 


Glu Ala Gln Thr Gly Glu Gly Ser Trp Pro Arg Ser Pro Ser Lys Ser 
                645                 650                 655     


Val Val Glu Gly Ile Ser Ser Gln Pro Gly Asn Ser Pro Ser Gly Thr 
            660                 665                 670         


Val Val 
        


<210>  3131
<211>  3048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMXL1__Homo_sapiens__NP_001277250

<400>  3131

Met Asn Leu His Gln Val Leu Thr Gly Ala Val Asn Pro Gly Asp His 
1               5                   10                  15      


Cys Phe Ser Val Gly Ser Ile Gly Asp Gln Arg Phe Thr Ala Tyr Ala 
            20                  25                  30          


Ser Gly Cys Asp Ile Val Ile Leu Gly Ser Asp Phe Glu Arg Leu Gln 
        35                  40                  45              


Ile Ile Pro Gly Ala Lys His Gly Asn Ile Gln Val Gly Cys Val Asp 
    50                  55                  60                  


Cys Ser Met Gln Gln Gly Lys Ile Ala Ala Ser Tyr Gly Asn Val Ile 
65                  70                  75                  80  


Ser Ile Phe Glu Pro Val Asn Leu Pro Lys Gln Lys Lys Asn Leu Glu 
                85                  90                  95      


Leu Tyr Ser Gln Trp Gln Lys Ser Gly Gln Phe Phe Leu Glu Ser Ile 
            100                 105                 110         


Ala His Asn Ile Thr Trp Asp Pro Thr Gly Ser Arg Leu Leu Thr Gly 
        115                 120                 125             


Ser Ser Tyr Leu Gln Leu Trp Ser Asn Thr Asn Leu Glu Lys Pro Thr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Asn Lys Thr Asp Leu Asn Phe Gly Asp Trp Lys 
145                 150                 155                 160 


Cys Ile Trp His Cys Lys Thr Ala Ser Gln Val His Leu Met Lys Phe 
                165                 170                 175     


Ser Pro Asp Gly Glu Phe Phe Ala Thr Ala Gly Lys Asp Asp Cys Leu 
            180                 185                 190         


Leu Lys Val Trp Tyr Asn Val Glu Asn Trp Arg Thr Ala Val Thr Ser 
        195                 200                 205             


Pro Asp Gly Ser Ser Glu Lys Gln Ser Gln Gly Glu Ile Asp Phe Ser 
    210                 215                 220                 


Phe Val Tyr Leu Ala His Pro Arg Ala Val Asn Gly Phe Ser Trp Arg 
225                 230                 235                 240 


Lys Thr Ser Lys Tyr Met Pro Arg Ala Ser Val Cys Asn Val Leu Leu 
                245                 250                 255     


Thr Cys Cys Lys Asp Asn Val Cys Arg Leu Trp Val Glu Thr Phe Leu 
            260                 265                 270         


Pro Asn Asp Cys Leu Leu Tyr Gly Gly Asp Cys Ser His Trp Thr Glu 
        275                 280                 285             


Ser Ile Asn Leu Thr Asn Asn Phe Lys Arg Asn Ala Ser Ser Lys Glu 
    290                 295                 300                 


Arg Val Gln Asn Ala Leu Glu Val Asn Leu Arg His Phe Arg Arg Gly 
305                 310                 315                 320 


Arg Arg Arg Ser Leu Ala Leu Val Ala His Thr Gly Tyr Leu Pro His 
                325                 330                 335     


Gln Gln Asp Pro His His Val His Arg Asn Thr Pro Leu His Ala Asn 
            340                 345                 350         


Ala Leu Cys His Phe His Ile Ala Ala Ser Ile Asn Pro Ala Thr Asp 
        355                 360                 365             


Ile Pro Leu Leu Pro Ser Ile Thr Ser Leu Ser Leu Asn Glu Asn Glu 
    370                 375                 380                 


Glu Lys Thr Gly Pro Phe Val Val His Trp Leu Asn Asn Lys Glu Leu 
385                 390                 395                 400 


His Phe Thr Leu Ser Met Glu Val Phe Leu Gln Gln Leu Arg Lys Ser 
                405                 410                 415     


Phe Glu Gln Pro Ser Ser Glu Ala Ser Val Glu Asp Ser Asn Gln Ala 
            420                 425                 430         


Asp Val Lys Ser Asp Glu Glu Thr Asp Asp Gly Val Asp Asp Leu Lys 
        435                 440                 445             


Ile Asn Pro Glu Lys Lys Glu Leu Gly Cys Asp Lys Met Val Pro Asn 
    450                 455                 460                 


Ser Ser Phe Thr Ser Leu Ser Ser Ala Ala Ile Asp His Gln Ile Glu 
465                 470                 475                 480 


Val Leu Leu Ser Glu Trp Ser Lys Asn Ala Asp Met Leu Phe Ser Ile 
                485                 490                 495     


His Pro Met Asp Gly Ser Leu Leu Val Trp His Val Asp Trp Leu Asp 
            500                 505                 510         


Glu Tyr Gln Pro Gly Met Phe Arg Gln Val Gln Val Ser Phe Val Ser 
        515                 520                 525             


Arg Ile Pro Val Ala Phe Pro Thr Gly Asp Ala Asn Ser Leu Cys Lys 
    530                 535                 540                 


Ser Ile Met Met Tyr Ala Cys Thr Lys Asn Val Asp Leu Ala Ile Gln 
545                 550                 555                 560 


Gln Gly Lys Gln Lys Pro Ser Gly Leu Thr Arg Ser Thr Ser Met Leu 
                565                 570                 575     


Ile Ser Ser Gly His Asn Lys Ser Ser Asn Ser Leu Lys Leu Ser Ile 
            580                 585                 590         


Phe Thr Pro Asn Val Met Met Ile Ser Lys His Ala Asp Gly Ser Leu 
        595                 600                 605             


Asn Gln Trp Leu Val Ser Phe Ala Glu Glu Ser Ala Phe Ser Thr Val 
    610                 615                 620                 


Leu Ser Ile Ser His Lys Ser Arg Tyr Cys Gly His Arg Phe His Leu 
625                 630                 635                 640 


Asn Asp Leu Ala Cys His Ser Val Leu Pro Leu Leu Leu Thr Thr Ser 
                645                 650                 655     


His His Asn Ala Leu Arg Thr Pro Asp Val Asp Asn Pro Glu Gln Pro 
            660                 665                 670         


Phe Asp Ala Leu Asn Ile Glu Glu Cys Ser Leu Thr Gln Gln Asn Lys 
        675                 680                 685             


Ser Thr Val Asp Val Ala Phe Gln Asp Pro Ser Ala Val Tyr Ser Glu 
    690                 695                 700                 


Leu Ile Leu Trp Arg Val Asp Pro Val Gly Pro Leu Ser Phe Ser Gly 
705                 710                 715                 720 


Gly Val Ser Glu Leu Ala Arg Ile Asn Ser Leu His Val Ser Ala Phe 
                725                 730                 735     


Ser Asn Val Ala Trp Leu Pro Thr Leu Ile Pro Ser Tyr Cys Leu Gly 
            740                 745                 750         


Ala Tyr Cys Asn Ser Pro Ser Ala Cys Phe Val Ala Ser Asp Gly Gln 
        755                 760                 765             


Tyr Leu Arg Leu Tyr Glu Ala Val Ile Asp Ala Lys Lys Leu Leu Ser 
    770                 775                 780                 


Glu Leu Ser Asn Pro Glu Ile Ser Lys Tyr Val Gly Glu Val Phe Asn 
785                 790                 795                 800 


Ile Val Ser Gln Gln Ser Thr Ala Arg Pro Gly Cys Ile Ile Ala Leu 
                805                 810                 815     


Asp Pro Ile Thr Lys Leu His Gly Arg Lys Thr Gln Leu Leu His Val 
            820                 825                 830         


Phe Glu Glu Asp Phe Ile Leu Asn Asn Leu Glu Lys Lys Ser Leu Gly 
        835                 840                 845             


Lys Asp Ser Ile Leu Ser Asn Ala Gly Ser Ser Pro Asn Gly Phe Ser 
    850                 855                 860                 


Glu Lys Phe Tyr Leu Ile Val Ile Glu Cys Thr Gln Asp Asn Arg Ser 
865                 870                 875                 880 


Leu Leu His Met Trp Asn Leu His Leu Lys Ser Ile Pro Val Ser Leu 
                885                 890                 895     


Asp Glu Lys Val Asp Thr Lys Leu Ser Glu Ala Val Trp Gln Pro Glu 
            900                 905                 910         


Glu His Tyr Ser Ser Ser Pro Glu Lys Ile Leu Ser Pro Phe Ser Gln 
        915                 920                 925             


Lys Tyr Gln Ala Cys Arg Ala Asn Leu Gln Ser Thr Ser Arg Leu Thr 
    930                 935                 940                 


Leu Phe Ser Glu Met Val Tyr Ser Gln Glu Leu His Leu Pro Glu Gly 
945                 950                 955                 960 


Val Glu Ile Ile Ser Ile Lys Pro Ser Ala Gly His Leu Ser Ser Ser 
                965                 970                 975     


Ser Ile Tyr Pro Ala Cys Ser Ala Pro Tyr Leu Leu Ala Thr Ser Cys 
            980                 985                 990         


Ser Asp Glu Lys Val Arg Phe Trp  Arg Cys Arg Val Thr  Asp Gly Glu 
        995                 1000                 1005             


Ser Ala  Thr Ser Lys Asn Gly  Lys Ile Asp Leu Ala  Tyr Ile Trp 
    1010                 1015                 1020             


Glu Glu  Trp Pro Leu Leu Ile  Glu Asp Gly Leu Gln  Ser Asn Ser 
    1025                 1030                 1035             


Ser Ile  Thr Val Pro Gly Arg  Pro Val Glu Val Ser  Cys Ala His 
    1040                 1045                 1050             


Thr Asn  Arg Leu Ala Val Ala  Tyr Lys Gln Pro Ala  Ser Asn Ser 
    1055                 1060                 1065             


Arg Ser  Ser Gln Asp Phe Val  Met His Val Ser Ile  Phe Glu Cys 
    1070                 1075                 1080             


Glu Ser  Thr Gly Gly Ser Cys  Trp Val Leu Glu Gln  Thr Ile His 
    1085                 1090                 1095             


Leu Asp  Glu Leu Ser Thr Val  Leu Asp Ser Gly Ile  Ser Val Asp 
    1100                 1105                 1110             


Ser Asn  Leu Val Ala Tyr Asn  Lys Gln Asp Met Tyr  Leu Ser Ser 
    1115                 1120                 1125             


Lys Glu  Asn Ile Thr Ser Asn  Thr Lys His Leu Val  His Leu Asp 
    1130                 1135                 1140             


Trp Met  Ser Arg Glu Asp Gly  Ser His Ile Leu Thr  Val Gly Ile 
    1145                 1150                 1155             


Gly Ser  Lys Leu Phe Met Tyr  Gly Pro Leu Ala Gly  Lys Val Gln 
    1160                 1165                 1170             


Asp Gln  Thr Gly Lys Glu Thr  Leu Ala Phe Pro Leu  Trp Glu Ser 
    1175                 1180                 1185             


Thr Lys  Val Val Pro Leu Ser  Lys Phe Val Leu Leu  Arg Ser Val 
    1190                 1195                 1200             


Asp Leu  Val Ser Ser Val Asp  Gly Ser Pro Pro Phe  Pro Val Ser 
    1205                 1210                 1215             


Leu Ser  Trp Val Arg Asp Gly  Ile Leu Val Val Gly  Met Asp Cys 
    1220                 1225                 1230             


Glu Met  His Val Tyr Cys Gln  Trp Gln Pro Ser Ser  Lys Gln Glu 
    1235                 1240                 1245             


Pro Val  Ile Thr Asp Ser Tyr  Ser Gly Ser Thr Pro  Ser Ile Thr 
    1250                 1255                 1260             


Ser Leu  Ile Lys Gln Ser Asn  Ser Ser Ser Gly Leu  His Pro Pro 
    1265                 1270                 1275             


Lys Lys  Thr Leu Thr Arg Ser  Met Thr Ser Leu Ala  Gln Lys Ile 
    1280                 1285                 1290             


Cys Gly  Lys Lys Thr Ala Phe  Asp Pro Ser Val Asp  Met Glu Asp 
    1295                 1300                 1305             


Ser Gly  Leu Phe Glu Ala Ala  His Val Leu Ser Pro  Thr Leu Pro 
    1310                 1315                 1320             


Gln Tyr  His Pro Leu Gln Leu  Leu Glu Leu Met Asp  Leu Gly Lys 
    1325                 1330                 1335             


Val Arg  Arg Ala Lys Ala Ile  Leu Ser His Leu Val  Lys Cys Ile 
    1340                 1345                 1350             


Ala Gly  Glu Val Val Ala Leu  Asn Glu Ala Glu Ser  Asn His Glu 
    1355                 1360                 1365             


Arg Arg  Leu Arg Ser Leu Thr  Ile Ser Ala Ser Gly  Ser Thr Thr 
    1370                 1375                 1380             


Arg Asp  Pro Gln Ala Phe Asn  Lys Ala Glu Asn Thr  Asp Tyr Thr 
    1385                 1390                 1395             


Glu Ile  Asp Ser Val Pro Pro  Leu Pro Leu Tyr Ala  Leu Leu Ala 
    1400                 1405                 1410             


Ala Asp  Asp Asp Ser Cys Tyr  Ser Ser Leu Glu Lys  Ser Ser Asn 
    1415                 1420                 1425             


Glu Ser  Thr Leu Ser Lys Ser  Asn Gln Leu Ser Lys  Glu Ser Tyr 
    1430                 1435                 1440             


Asp Glu  Leu Phe Gln Thr Gln  Leu Leu Met Thr Asp  Thr His Met 
    1445                 1450                 1455             


Leu Glu  Thr Asp Glu Glu Asn  Thr Lys Pro Arg Val  Ile Asp Leu 
    1460                 1465                 1470             


Ser Gln  Tyr Ser Pro Thr Tyr  Phe Gly Pro Glu His  Ala Gln Val 
    1475                 1480                 1485             


Leu Ser  Gly His Leu Leu His  Ser Ser Leu Pro Gly  Leu Ser Arg 
    1490                 1495                 1500             


Met Glu  Gln Met Ser Leu Met  Ala Leu Ala Asp Thr  Ile Ala Thr 
    1505                 1510                 1515             


Thr Ser  Thr Asp Ile Gly Glu  Ser Arg Asp Arg Ser  Gln Gly Gly 
    1520                 1525                 1530             


Glu Thr  Leu Asp Glu Cys Gly  Leu Lys Phe Leu Leu  Ala Val Arg 
    1535                 1540                 1545             


Leu His  Thr Phe Leu Thr Thr  Ser Leu Pro Ala Tyr  Arg Ala Gln 
    1550                 1555                 1560             


Leu Leu  His Gln Gly Leu Ser  Thr Ser His Phe Ala  Trp Ala Phe 
    1565                 1570                 1575             


His Ser  Val Ala Glu Glu Glu  Leu Leu Asn Met Leu  Pro Ala Met 
    1580                 1585                 1590             


Gln Lys  Asp Asp Pro Thr Trp  Ser Glu Leu Arg Ala  Met Gly Val 
    1595                 1600                 1605             


Gly Trp  Trp Val Arg Asn Thr  Arg Ile Leu Arg Lys  Cys Ile Glu 
    1610                 1615                 1620             


Lys Val  Ala Lys Ala Ala Phe  Tyr Arg Lys Asn Asp  Pro Leu Asp 
    1625                 1630                 1635             


Ala Ala  Ile Phe Tyr Leu Ala  Met Lys Lys Lys Ala  Val Ile Trp 
    1640                 1645                 1650             


Gly Leu  Tyr Arg Ala Glu Lys  Asn Thr Arg Met Thr  Gln Phe Phe 
    1655                 1660                 1665             


Gly His  Asn Phe Glu Asp Glu  Arg Trp Arg Lys Ala  Ala Leu Lys 
    1670                 1675                 1680             


Asn Ala  Phe Ser Leu Leu Gly  Lys Gln Arg Phe Glu  His Ser Ala 
    1685                 1690                 1695             


Ala Phe  Phe Leu Leu Ala Gly  Cys Leu Arg Asp Ala  Ile Glu Val 
    1700                 1705                 1710             


Cys Leu  Glu Lys Leu Asn Asp  Ile Gln Leu Ala Leu  Val Ile Ala 
    1715                 1720                 1725             


Arg Leu  Tyr Glu Ser Glu Phe  Asp Thr Ser Ala Ala  Tyr Lys Ser 
    1730                 1735                 1740             


Ile Leu  Arg Lys Lys Val Leu  Gly Ile Asp Ser Pro  Val Ser Glu 
    1745                 1750                 1755             


Leu Cys  Ser Leu Asn Ile Asn  Met His His Asp Pro  Phe Leu Arg 
    1760                 1765                 1770             


Ser Met  Ala Tyr Trp Ile Leu  Glu Asp Tyr Ser Gly  Ala Leu Glu 
    1775                 1780                 1785             


Thr Leu  Ile Lys Gln Pro Ile  Arg Glu Asn Asp Asp  Gln Val Leu 
    1790                 1795                 1800             


Ser Ala  Ser Asn Pro Thr Val  Phe Asn Phe Tyr Asn  Tyr Leu Arg 
    1805                 1810                 1815             


Thr His  Pro Leu Leu Leu Arg  Arg His Phe Gly Ser  Ser Asp Thr 
    1820                 1825                 1830             


Phe Ser  Thr His Met Ser Leu  Thr Gly Lys Ser Gly  Leu Ala Gly 
    1835                 1840                 1845             


Thr Ile  Asn Leu Ser Glu Arg  Arg Leu Phe Phe Thr  Thr Ala Ser 
    1850                 1855                 1860             


Ala His  Leu Lys Ala Gly Cys  Pro Met Leu Ala Leu  Glu Val Leu 
    1865                 1870                 1875             


Ser Lys  Met Pro Lys Val Ile  Lys Lys Thr Arg Pro  Phe Tyr Arg 
    1880                 1885                 1890             


Ala Ser  Ser Phe Leu Asp Thr  Ser Lys Asp Cys Ser  Pro Ser Ser 
    1895                 1900                 1905             


Pro Leu  Lys Leu Asp Ala Arg  Glu Asp Lys Ser Ser  Ala Val Asp 
    1910                 1915                 1920             


Trp Ser  Gln Ser Leu Ile Asn  Gly Phe Gly Ser Ser  Ser Glu Gly 
    1925                 1930                 1935             


Ser Ser  Glu Lys Gln Ser Asn  Ser Thr Leu Ser Phe  Asp Trp Ser 
    1940                 1945                 1950             


Gln Pro  Ser Val Val Phe Gln  Asp Asp Ser Leu Glu  Leu Lys Trp 
    1955                 1960                 1965             


Asp Ser  Asp Asn Asp Glu Glu  Asn Glu Asp Val Pro  Ile Ser Met 
    1970                 1975                 1980             


Lys Glu  Leu Lys Pro Leu Gln  Arg Lys Thr Asp Lys  Lys Leu Asp 
    1985                 1990                 1995             


Asp Ile  Ser Ser Asn Tyr Thr  Glu Ser Phe Ser Thr  Leu Asp Glu 
    2000                 2005                 2010             


Asn Asp  Leu Leu Asn Pro Ser  Glu Asp Ile Ile Ala  Val Gln Leu 
    2015                 2020                 2025             


Lys Phe  Arg Ala Cys Leu Lys  Ile Leu Thr Val Glu  Leu Arg Thr 
    2030                 2035                 2040             


Leu Ser  Thr Gly Tyr Glu Ile  Asp Gly Gly Lys Leu  Arg Tyr Gln 
    2045                 2050                 2055             


Leu Tyr  His Trp Leu Glu Lys  Glu Val Ile Ala Leu  Gln Arg Thr 
    2060                 2065                 2070             


Cys Asp  Phe Cys Ser Asp Ala  Glu Glu Leu Gln Ser  Ala Phe Gly 
    2075                 2080                 2085             


Arg Asn  Glu Asp Glu Phe Gly  Leu Asn Glu Asp Ala  Glu Asp Leu 
    2090                 2095                 2100             


Pro His  Gln Thr Lys Val Lys  Gln Leu Arg Glu Asn  Phe Gln Glu 
    2105                 2110                 2115             


Lys Arg  Gln Trp Leu Leu Lys  Tyr Gln Ser Leu Leu  Arg Met Phe 
    2120                 2125                 2130             


Leu Ser  Tyr Cys Ile Leu His  Gly Ser His Gly Gly  Gly Leu Ala 
    2135                 2140                 2145             


Ser Val  Arg Met Glu Leu Ile  Leu Leu Leu Gln Glu  Ser Gln Gln 
    2150                 2155                 2160             


Glu Thr  Ser Glu Pro Leu Phe  Ser Ser Pro Leu Ser  Glu Gln Thr 
    2165                 2170                 2175             


Ser Val  Pro Leu Leu Phe Ala  Cys Thr Ala Asn Ala  Lys Thr Val 
    2180                 2185                 2190             


Val Ala  Asn Pro Leu Leu His  Leu Ser Asn Leu Thr  His Asp Ile 
    2195                 2200                 2205             


Leu His  Ala Ile Ile Asn Phe  Asp Ser Pro Pro His  Pro Asp Ile 
    2210                 2215                 2220             


Gln Ser  Asn Lys Val Tyr Val  Met His Thr Leu Ala  Ala Ser Leu 
    2225                 2230                 2235             


Ser Ala  Cys Ile Tyr Gln Cys  Leu Cys Gly Ser His  Asn Tyr Ser 
    2240                 2245                 2250             


Ser Phe  Gln Thr Asn Gln Phe  Thr Gly Met Val Tyr  Gln Thr Val 
    2255                 2260                 2265             


Leu Leu  Pro His Arg Pro Ser  Leu Lys Thr Gly Ser  Leu Asp Glu 
    2270                 2275                 2280             


Ala Leu  Thr Pro Asn Thr Ser  Pro Ala Gln Trp Pro  Gly Ile Thr 
    2285                 2290                 2295             


Cys Leu  Ile Arg Leu Leu Asn  Ser Ser Gly Glu Glu  Ala Gln Ser 
    2300                 2305                 2310             


Gly Leu  Thr Val Leu Leu Cys  Glu Ile Leu Thr Ala  Val Tyr Leu 
    2315                 2320                 2325             


Ser Leu  Phe Ile His Gly Leu  Ala Thr His Ser Ser  Asn Glu Leu 
    2330                 2335                 2340             


Phe Arg  Ile Val Ala His Pro  Leu Asn Glu Lys Met  Trp Ser Ala 
    2345                 2350                 2355             


Val Phe  Gly Gly Gly Ala His  Val Pro Ser Lys Glu  Gln Thr His 
    2360                 2365                 2370             


Ser Lys  Thr Leu Pro Val Ser  Ser Leu Val Glu Glu  Gly Glu Lys 
    2375                 2380                 2385             


Gln Asn  Lys Arg Phe Arg Pro  Ser Lys Met Ser Cys  Arg Glu Ser 
    2390                 2395                 2400             


Ala Pro  Leu Thr Pro Ser Ser  Ala Pro Val Ser Gln  Glu Ser Leu 
    2405                 2410                 2415             


Ala Val  Lys Glu Lys Phe Ile  Pro Pro Glu Leu Ser  Ile Trp Asp 
    2420                 2425                 2430             


Tyr Phe  Ile Ala Lys Pro Phe  Leu Pro Ser Ser Gln  Ser Arg Ala 
    2435                 2440                 2445             


Glu Tyr  Asp Ser Glu Glu Ser  Leu Gly Ser Asp Asp  Asp Asp Asn 
    2450                 2455                 2460             


Asp Asp  Asp Asp Asp Val Leu  Ala Ser Asp Phe His  Leu Gln Glu 
    2465                 2470                 2475             


His Ser  Asn Ser Asn Ser Tyr  Ser Trp Ser Leu Met  Arg Leu Ala 
    2480                 2485                 2490             


Met Val  Gln Leu Val Leu Asn  Asn Leu Lys Thr Phe  Tyr Pro Phe 
    2495                 2500                 2505             


Ala Gly  His Asp Leu Ala Glu  Leu Pro Val Ser Ser  Pro Leu Cys 
    2510                 2515                 2520             


His Ala  Val Leu Lys Thr Leu  Gln Cys Trp Glu Gln  Val Leu Leu 
    2525                 2530                 2535             


Arg Arg  Leu Glu Ile His Gly  Gly Pro Pro Gln Asn  Tyr Ile Ala 
    2540                 2545                 2550             


Ser His  Thr Ala Glu Glu Ser  Leu Ser Ala Gly Pro  Ala Ile Leu 
    2555                 2560                 2565             


Arg His  Lys Ala Leu Leu Glu  Pro Thr Asn Thr Pro  Phe Lys Ser 
    2570                 2575                 2580             


Lys His  His Leu Ala Leu Ser  Val Lys Arg Leu Trp  Gln Tyr Leu 
    2585                 2590                 2595             


Val Lys  Gln Glu Glu Ile Gln  Glu Thr Phe Ile Lys  Asn Ile Phe 
    2600                 2605                 2610             


Thr Lys  Lys Arg Cys Leu Asn  Glu Ser Leu Glu Asp  Asn Ser Glu 
    2615                 2620                 2625             


Thr Ile  Lys Asn Ser Met Met  Glu Glu Pro Asn Ile  Asn Lys Ile 
    2630                 2635                 2640             


Glu Ala  Asp Leu Gly Tyr Pro  Gly Gly Lys Ala Arg  Ile Ile His 
    2645                 2650                 2655             


Lys Glu  Ser Asp Ile Ile Thr  Ala Phe Ala Val Asn  Lys Ala Asn 
    2660                 2665                 2670             


Arg Asn  Cys Ile Ala Ile Ala  Ser Ser His Asp Val  Gln Glu Leu 
    2675                 2680                 2685             


Asp Val  Ser Gly Ile Leu Ala  Thr Gln Val Tyr Thr  Trp Val Asp 
    2690                 2695                 2700             


Asp Asp  Ile Glu Val Glu Thr  Lys Gly Ser Glu Asp  Phe Leu Val 
    2705                 2710                 2715             


Ile His  Ala Arg Asp Asp Leu  Thr Ala Val Gln Gly  Thr Thr Pro 
    2720                 2725                 2730             


Tyr Thr  His Ser Asn Pro Gly  Thr Pro Ile Asn Met  Pro Trp Leu 
    2735                 2740                 2745             


Gly Ser  Thr Gln Thr Gly Arg  Gly Ala Ser Val Met  Ile Lys Lys 
    2750                 2755                 2760             


Ala Ile  Asn Asn Val Arg Arg  Met Thr Ser His Pro  Thr Leu Pro 
    2765                 2770                 2775             


Tyr Tyr  Leu Thr Gly Ala Gln  Asp Gly Ser Val Arg  Met Phe Glu 
    2780                 2785                 2790             


Trp Gly  His Ser Gln Gln Ile  Thr Cys Phe Arg Ser  Gly Gly Asn 
    2795                 2800                 2805             


Ser Arg  Val Thr Arg Met Arg  Phe Asn Tyr Gln Gly  Asn Lys Phe 
    2810                 2815                 2820             


Gly Ile  Val Asp Ala Asp Gly  Tyr Leu Ser Leu Tyr  Gln Thr Asn 
    2825                 2830                 2835             


Trp Lys  Cys Cys Pro Val Thr  Gly Ser Met Pro Lys  Pro Tyr Leu 
    2840                 2845                 2850             


Thr Trp  Gln Cys His Asn Lys  Thr Ala Asn Asp Phe  Val Phe Val 
    2855                 2860                 2865             


Ser Ser  Ser Ser Leu Ile Ala  Thr Ala Gly Leu Ser  Thr Asp Asn 
    2870                 2875                 2880             


Arg Asn  Val Cys Leu Trp Asp  Thr Leu Val Ala Pro  Ala Asn Ser 
    2885                 2890                 2895             


Leu Val  His Ala Phe Thr Cys  His Asp Ser Gly Ala  Thr Val Leu 
    2900                 2905                 2910             


Ala Tyr  Ala Pro Lys His Gln  Leu Leu Ile Ser Gly  Gly Arg Lys 
    2915                 2920                 2925             


Gly Phe  Thr Tyr Val Phe Asp  Leu Cys Gln Arg Gln  Gln Arg Gln 
    2930                 2935                 2940             


Leu Phe  Gln Ser His Asp Ser  Pro Val Lys Ala Val  Ala Val Asp 
    2945                 2950                 2955             


Pro Thr  Glu Glu Tyr Phe Val  Thr Gly Ser Ala Glu  Gly Asn Ile 
    2960                 2965                 2970             


Lys Ile  Trp Ser Leu Ser Thr  Phe Gly Leu Leu His  Thr Phe Val 
    2975                 2980                 2985             


Ser Glu  His Ala Arg Gln Ser  Ile Phe Arg Asn Ile  Gly Thr Gly 
    2990                 2995                 3000             


Val Met  Gln Ile Glu Thr Gly  Pro Ala Asn His Ile  Phe Ser Cys 
    3005                 3010                 3015             


Gly Ala  Asp Gly Thr Met Lys  Met Arg Ile Leu Pro  Asp Gln Phe 
    3020                 3025                 3030             


Ser Pro  Leu Asn Glu Val Leu  Lys Asn Asp Val Lys  Phe Met Leu 
    3035                 3040                 3045             


<210>  3132
<211>  3037
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMXL2__Homo_sapiens__NP_001167587

<400>  3132

Met His Leu His Gln Val Leu Thr Gly Ala Val Asn Pro Gly Asp Asn 
1               5                   10                  15      


Cys Tyr Ser Val Gly Ser Val Gly Asp Val Pro Phe Thr Ala Tyr Gly 
            20                  25                  30          


Ser Gly Cys Asp Ile Val Ile Leu Ala Asn Asp Phe Glu Cys Val Gln 
        35                  40                  45              


Ile Ile Pro Gly Ala Lys His Gly Asn Ile Gln Val Ser Cys Val Glu 
    50                  55                  60                  


Cys Ser Asn Gln Gln Gly Arg Ile Ala Ala Ser Tyr Gly Asn Ala Val 
65                  70                  75                  80  


Cys Ile Phe Glu Pro Leu Gly Ile Asn Ser His Lys Arg Asn Cys Gln 
                85                  90                  95      


Leu Lys Cys Gln Trp Leu Lys Thr Gly Gln Phe Phe Leu Ser Ser Val 
            100                 105                 110         


Thr Tyr Asn Leu Ala Trp Asp Pro Gln Asp Asn Arg Leu Leu Thr Ala 
        115                 120                 125             


Thr Asp Ser Ile Gln Leu Trp Ala Pro Pro Gly Asp Asp Ile Leu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Ile Asp Asn Thr Val Pro Pro Val Leu Asn Asp Trp 
145                 150                 155                 160 


Lys Cys Val Trp Gln Cys Lys Thr Ser Val Ser Val His Leu Met Glu 
                165                 170                 175     


Trp Ser Pro Asp Gly Glu Tyr Phe Ala Thr Ala Gly Lys Asp Asp Cys 
            180                 185                 190         


Leu Leu Lys Val Trp Tyr Pro Met Thr Gly Trp Lys Ser Ser Ile Ile 
        195                 200                 205             


Pro Gln Asp His His Glu Val Lys Arg Arg Gln Ser Ser Thr Gln Phe 
    210                 215                 220                 


Ser Phe Val Tyr Leu Ala His Pro Arg Ala Val Thr Gly Phe Ser Trp 
225                 230                 235                 240 


Arg Lys Thr Ser Lys Tyr Met Pro Arg Gly Ser Val Cys Asn Val Leu 
                245                 250                 255     


Leu Thr Ser Cys His Asp Gly Val Cys Arg Leu Trp Ala Glu Thr Leu 
            260                 265                 270         


Leu Pro Glu Asp Cys Leu Leu Gly Glu Gln Ile Cys Glu Thr Thr Thr 
        275                 280                 285             


Ser Ser Ile Ala Ser Ser Leu Ser His Ala Gly Arg His Lys Asp Arg 
    290                 295                 300                 


Ile Gln His Ala Leu Glu Thr Ile His His Leu Lys Asn Leu Arg Lys 
305                 310                 315                 320 


Gly Gln Arg Arg Ser Ser Val Leu Val Thr His Ala Glu Leu Met Pro 
                325                 330                 335     


Asp Gln Thr Ala Met His Glu Val Gln Arg His Ile Ser His His Ala 
            340                 345                 350         


Asn Ala Leu Cys His Phe His Ile Ala Ala Ser Ile Asn Pro Ala Thr 
        355                 360                 365             


Asp Ile Pro Asn Val Leu Val Gly Thr Ala Phe Asn Val Asp Asp Gly 
    370                 375                 380                 


Asn Gly Gly Phe Val Val His Trp Leu Asn Asn Lys Glu Phe His Phe 
385                 390                 395                 400 


Thr Ser Ser Thr Glu Val Phe Met His Gln Leu Arg Lys Leu Ser Asp 
                405                 410                 415     


Lys Gln Val Asp His Glu Asn Asp Asp Ala Asp Arg Glu Asp Glu Glu 
            420                 425                 430         


His Ser Gln Glu Asp Arg Glu Arg Gly Leu His Met Lys Leu Asp His 
        435                 440                 445             


Asp Leu Ser Leu Asp Arg Glu Ser Glu Ala Gly Thr Gly Ser Ser Glu 
    450                 455                 460                 


His Glu Asp Gly Glu Arg Glu Gly Ser Pro Arg Thr Tyr Ser Arg Leu 
465                 470                 475                 480 


Ser Val Pro Met Pro Leu Pro Thr Val Leu Leu Asp Arg Lys Ile Glu 
                485                 490                 495     


Thr Leu Leu Thr Glu Trp Asn Lys Asn Pro Asp Met Leu Phe Thr Ile 
            500                 505                 510         


His Pro Val Asp Gly Thr Phe Leu Val Trp His Val Lys Tyr Leu Asp 
        515                 520                 525             


Glu Tyr Asn Pro Gly Ile Phe Arg Gln Val Gln Val Ser Phe Ser Ser 
    530                 535                 540                 


Arg Ile Pro Val Ala Phe Pro Ser Gly Asp Ala Ser Ser Leu Ser Lys 
545                 550                 555                 560 


Asn Ile Met Met Tyr Ala Cys Ile Asn Ala Thr Lys Asp Ser His His 
                565                 570                 575     


Thr Leu Leu His Gln Glu Gly Met Ser Val Gly Ser Pro His Gly Ser 
            580                 585                 590         


Gln Pro His Ser Arg Ser His Ser Thr His Met Asn Ile Leu Ala Pro 
        595                 600                 605             


Thr Val Met Met Ile Ser Lys His Ile Asp Gly Ser Leu Asn Gln Trp 
    610                 615                 620                 


Ala Val Thr Phe Ala Asp Lys Ser Ala Phe Thr Thr Val Leu Thr Val 
625                 630                 635                 640 


Ser His Lys Phe Arg Tyr Cys Gly His Arg Phe His Leu Asn Asp Leu 
                645                 650                 655     


Ala Cys His Ser Val Leu Pro Leu Leu Leu Thr Ser Ser His His Asn 
            660                 665                 670         


Ala Leu Leu Thr Pro Glu Leu Asp Cys Gln Trp Asp Ser Asp Asn Lys 
        675                 680                 685             


Leu Ser Arg Leu Met Asp Pro Val Lys His Ile Lys Gly Ser Ser Lys 
    690                 695                 700                 


Gln Pro Leu Arg Asn Ala Ala Thr Arg Thr Phe His Asp Pro Asn Ala 
705                 710                 715                 720 


Ile Tyr Ser Glu Leu Ile Leu Trp Arg Val Asp Pro Ile Gly Pro Leu 
                725                 730                 735     


Ser Tyr Thr Gly Gly Val Ser Glu Leu Ala Arg Ile Asn Ser Leu His 
            740                 745                 750         


Thr Ser Ala Phe Ser Asn Val Ala Trp Leu Pro Thr Leu Ile Pro Ser 
        755                 760                 765             


Tyr Cys Leu Gly Thr Tyr Cys Asn Ser Ala Ser Ala Cys Phe Val Ala 
    770                 775                 780                 


Ser Asp Gly Lys Asn Leu Arg Leu Tyr Gln Ala Val Val Asp Ala Arg 
785                 790                 795                 800 


Lys Leu Leu Asp Glu Leu Ser Asp Pro Glu Ser Ser Lys Leu Ile Gly 
                805                 810                 815     


Glu Val Phe Asn Ile Val Ser Gln Gln Ser Thr Ala Arg Pro Gly Cys 
            820                 825                 830         


Ile Ile Glu Leu Asp Ala Ile Thr Asn Gln Cys Gly Ser Asn Thr Gln 
        835                 840                 845             


Leu Leu His Val Phe Gln Glu Asp Phe Ile Ile Gly Tyr Lys Pro His 
    850                 855                 860                 


Lys Glu Asp Met Glu Lys Lys Glu Thr Glu Ile Phe Phe Gln Pro Ser 
865                 870                 875                 880 


Gln Gly Tyr Arg Pro Pro Pro Phe Ser Glu Lys Phe Phe Leu Val Val 
                885                 890                 895     


Ile Glu Lys Asp Ser Asn Asn Asn Ser Ile Leu His Met Trp His Leu 
            900                 905                 910         


His Leu Lys Ser Val Gln Ala Cys Leu Ala Lys Ala Ser Glu Gly Ala 
        915                 920                 925             


Ser Ser Glu Ser Leu Leu Ser Val Pro Gly Gln Lys Asn Val Asp Ser 
    930                 935                 940                 


Ser Pro Glu Thr Ser Pro Ser Val Ser Pro Met Pro His Ser Ser Ser 
945                 950                 955                 960 


Ile Ala Asn Leu Gln Thr Ala Ser Lys Leu Ile Leu Ser Ser Arg Leu 
                965                 970                 975     


Val Tyr Ser Gln Pro Leu Asp Leu Pro Glu Ser Val Glu Val Ile Arg 
            980                 985                 990         


Ala Thr Pro Ser Ala Gly His Leu  Ser Ser Ser Ser Ile  Tyr Pro Val 
        995                 1000                 1005             


Cys Leu  Ala Pro Tyr Leu Val  Val Thr Thr Cys Ser  Asp Asn Lys 
    1010                 1015                 1020             


Val Arg  Phe Trp Lys Cys Cys  Met Glu Ala Asn Pro  Glu Cys Asn 
    1025                 1030                 1035             


Lys Ser  Asp Glu Lys Glu Ile  Tyr His Trp Lys Arg  Trp Pro Leu 
    1040                 1045                 1050             


Met Asn  Asp Glu Gly Glu Asp  Asn Ser Ser Thr Val  Ser Ile Val 
    1055                 1060                 1065             


Gly Arg  Pro Val Ala Val Ser  Cys Ser Tyr Thr Gly  Arg Leu Ala 
    1070                 1075                 1080             


Val Ala  Tyr Lys Gln Pro Ile  His His Asn Gly Phe  Val Ser Lys 
    1085                 1090                 1095             


Glu Phe  Ser Met His Val Cys  Ile Phe Glu Cys Glu  Ser Thr Gly 
    1100                 1105                 1110             


Gly Ser  Glu Trp Val Leu Glu  Gln Thr Ile His Leu  Asp Asp Leu 
    1115                 1120                 1125             


Val Lys  Val Gly Ser Val Leu  Asp Ser Arg Val Ser  Val Asp Ser 
    1130                 1135                 1140             


Asn Leu  Phe Val Tyr Ser Lys  Ser Asp Ala Leu Leu  Ser Lys Asp 
    1145                 1150                 1155             


Arg Tyr  Leu Ile Pro Asn Ile  Lys His Leu Val His  Leu Asp Trp 
    1160                 1165                 1170             


Val Ser  Lys Glu Asp Gly Ser  His Ile Leu Thr Val  Gly Val Gly 
    1175                 1180                 1185             


Ala Asn  Ile Phe Met Tyr Gly  Arg Leu Ser Gly Ile  Val Thr Glu 
    1190                 1195                 1200             


Gln Thr  Asn Ser Lys Asp Gly  Val Ala Val Ile Thr  Leu Pro Leu 
    1205                 1210                 1215             


Gly Gly  Ser Ile Lys Gln Gly  Val Lys Ser Arg Trp  Val Leu Leu 
    1220                 1225                 1230             


Arg Ser  Ile Asp Leu Val Ser  Ser Val Asp Gly Thr  Pro Ser Leu 
    1235                 1240                 1245             


Pro Val  Ser Leu Ser Trp Val  Arg Asp Gly Ile Leu  Val Val Gly 
    1250                 1255                 1260             


Met Asp  Cys Glu Met His Val  Tyr Ala Gln Trp Lys  His Ala Val 
    1265                 1270                 1275             


Lys Phe  Gly Asp Thr Glu Ala  Asp Ser Ser Asn Ala  Glu Glu Ala 
    1280                 1285                 1290             


Ala Met  Gln Asp His Ser Thr  Phe Lys Ser Asn Met  Leu Ala Arg 
    1295                 1300                 1305             


Lys Ser  Val Val Glu Gly Thr  Ala Ile Ser Asp Asp  Val Phe Cys 
    1310                 1315                 1320             


Ser Pro  Thr Val Ile Gln Asp  Gly Gly Leu Phe Glu  Ala Ala His 
    1325                 1330                 1335             


Val Leu  Ser Pro Thr Leu Pro  Gln Tyr His Pro Thr  Gln Leu Leu 
    1340                 1345                 1350             


Glu Leu  Met Asp Leu Gly Lys  Val Arg Arg Ala Lys  Ala Ile Leu 
    1355                 1360                 1365             


Ser His  Leu Val Lys Cys Ile  Ala Gly Glu Val Ala  Ile Val Arg 
    1370                 1375                 1380             


Asp Pro  Asp Ala Gly Glu Gly  Thr Lys Arg His Leu  Ser Arg Thr 
    1385                 1390                 1395             


Ile Ser  Val Ser Gly Ser Thr  Ala Lys Glu Thr Val  Thr Val Gly 
    1400                 1405                 1410             


Lys Asp  Gly Thr Arg Asp Tyr  Thr Glu Ile Asp Ser  Ile Pro Pro 
    1415                 1420                 1425             


Leu Pro  Leu Tyr Ala Leu Leu  Ala Ala Asp Gln Asp  Thr Ser Tyr 
    1430                 1435                 1440             


Arg Ile  Ser Glu Glu Ser Thr  Lys Ile Pro Gln Ser  Tyr Glu Asp 
    1445                 1450                 1455             


Gln Thr  Val Ser Gln Pro Glu  Asp Gln Tyr Ser Glu  Leu Phe Gln 
    1460                 1465                 1470             


Ile Gln  Asp Ile Pro Thr Asp  Asp Ile Asp Leu Glu  Pro Glu Lys 
    1475                 1480                 1485             


Arg Glu  Asn Lys Ser Lys Val  Ile Asn Leu Ser Gln  Tyr Gly Pro 
    1490                 1495                 1500             


Ala Tyr  Phe Gly Gln Glu His  Ala Arg Val Leu Ser  Ser His Leu 
    1505                 1510                 1515             


Met His  Ser Ser Leu Pro Gly  Leu Thr Arg Leu Glu  Gln Met Phe 
    1520                 1525                 1530             


Leu Val  Ala Leu Ala Asp Thr  Val Ala Thr Thr Ser  Thr Glu Leu 
    1535                 1540                 1545             


Asp Glu  Ser Arg Asp Lys Ser  Cys Ser Gly Arg Asp  Thr Leu Asp 
    1550                 1555                 1560             


Glu Cys  Gly Leu Arg Tyr Leu  Leu Ala Met Arg Leu  His Thr Cys 
    1565                 1570                 1575             


Leu Leu  Thr Ser Leu Pro Pro  Leu Tyr Arg Val Gln  Leu Leu His 
    1580                 1585                 1590             


Gln Gly  Val Ser Thr Cys His  Phe Ala Trp Ala Phe  His Ser Glu 
    1595                 1600                 1605             


Ala Glu  Glu Glu Leu Ile Asn  Met Ile Pro Ala Ile  Gln Arg Gly 
    1610                 1615                 1620             


Asp Pro  Gln Trp Ser Glu Leu  Arg Ala Met Gly Ile  Gly Trp Trp 
    1625                 1630                 1635             


Val Arg  Asn Ile Asn Thr Leu  Arg Arg Cys Ile Glu  Lys Val Ala 
    1640                 1645                 1650             


Lys Ala  Ser Phe Gln Arg Asn  Asn Asp Ala Leu Asp  Ala Ala Leu 
    1655                 1660                 1665             


Phe Tyr  Leu Ser Met Lys Lys  Lys Ala Val Val Trp  Gly Leu Phe 
    1670                 1675                 1680             


Arg Ser  Gln His Asp Glu Lys  Met Thr Thr Phe Phe  Ser His Asn 
    1685                 1690                 1695             


Phe Asn  Glu Asp Arg Trp Arg  Lys Ala Ala Leu Lys  Asn Ala Phe 
    1700                 1705                 1710             


Ser Leu  Leu Gly Lys Gln Arg  Phe Glu Gln Ser Ala  Ala Phe Phe 
    1715                 1720                 1725             


Leu Leu  Ala Gly Ser Leu Lys  Asp Ala Ile Glu Val  Cys Leu Glu 
    1730                 1735                 1740             


Lys Met  Glu Asp Ile Gln Leu  Ala Met Val Ile Ala  Arg Leu Tyr 
    1745                 1750                 1755             


Glu Ser  Glu Phe Glu Thr Ser  Ser Thr Tyr Ile Ser  Ile Leu Asn 
    1760                 1765                 1770             


Gln Lys  Ile Leu Gly Cys Gln  Lys Asp Gly Ser Gly  Phe Ser Cys 
    1775                 1780                 1785             


Lys Arg  Leu His Pro Asp Pro  Phe Leu Arg Ser Leu  Ala Tyr Trp 
    1790                 1795                 1800             


Val Met  Lys Asp Tyr Thr Arg  Ala Leu Asp Thr Leu  Leu Glu Gln 
    1805                 1810                 1815             


Thr Pro  Lys Glu Asp Asp Glu  His Gln Val Ile Ile  Lys Ser Cys 
    1820                 1825                 1830             


Asn Pro  Val Ala Phe Ser Phe  Tyr Asn Tyr Leu Arg  Thr His Pro 
    1835                 1840                 1845             


Leu Leu  Ile Arg Arg Asn Leu  Ala Ser Pro Glu Gly  Thr Leu Ala 
    1850                 1855                 1860             


Thr Leu  Gly Leu Lys Thr Glu  Lys Asn Phe Val Asp  Lys Ile Asn 
    1865                 1870                 1875             


Leu Ile  Glu Arg Lys Leu Phe  Phe Thr Thr Ala Asn  Ala His Phe 
    1880                 1885                 1890             


Lys Val  Gly Cys Pro Val Leu  Ala Leu Glu Val Leu  Ser Lys Ile 
    1895                 1900                 1905             


Pro Lys  Val Thr Lys Thr Ser  Ala Leu Ser Ala Lys  Lys Asp Gln 
    1910                 1915                 1920             


Pro Asp  Phe Ile Ser His Arg  Met Asp Asp Val Pro  Ser His Ser 
    1925                 1930                 1935             


Lys Ala  Leu Ser Asp Gly Asn  Gly Ser Ser Gly Ile  Glu Trp Ser 
    1940                 1945                 1950             


Asn Val  Thr Ser Ser Gln Tyr  Asp Trp Ser Gln Pro  Ile Val Lys 
    1955                 1960                 1965             


Val Asp  Glu Glu Pro Leu Asn  Leu Asp Trp Gly Glu  Asp His Asp 
    1970                 1975                 1980             


Ser Ala  Leu Asp Glu Glu Glu  Asp Asp Ala Val Gly  Leu Val Met 
    1985                 1990                 1995             


Lys Ser  Thr Asp Ala Arg Glu  Lys Asp Lys Gln Ser  Asp Gln Lys 
    2000                 2005                 2010             


Ala Ser  Asp Pro Asn Met Leu  Leu Thr Pro Gln Glu  Glu Asp Asp 
    2015                 2020                 2025             


Pro Glu  Gly Asp Thr Glu Val  Asp Val Ile Ala Glu  Gln Leu Lys 
    2030                 2035                 2040             


Phe Arg  Ala Cys Leu Lys Ile  Leu Met Thr Glu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Ala Thr  Gly Tyr Glu Val Asp  Gly Gly Lys Leu Arg  Phe Gln Leu 
    2060                 2065                 2070             


Tyr Asn  Trp Leu Glu Lys Glu  Ile Ala Ala Leu His  Glu Ile Cys 
    2075                 2080                 2085             


Asn His  Glu Ser Val Ile Lys  Glu Tyr Ser Ser Lys  Thr Tyr Ser 
    2090                 2095                 2100             


Lys Val  Glu Ser Asp Leu Leu  Asp Gln Glu Glu Met  Val Asp Lys 
    2105                 2110                 2115             


Pro Asp  Ile Gly Ser Tyr Glu  Arg His Gln Ile Glu  Arg Arg Arg 
    2120                 2125                 2130             


Leu Gln  Ala Lys Arg Glu His  Ala Glu Arg Arg Lys  Ser Trp Leu 
    2135                 2140                 2145             


Gln Lys  Asn Gln Asp Leu Leu  Arg Val Phe Leu Ser  Tyr Cys Ser 
    2150                 2155                 2160             


Leu His  Gly Ala Gln Gly Gly  Gly Leu Ala Ser Val  Arg Met Glu 
    2165                 2170                 2175             


Leu Lys  Phe Leu Leu Gln Glu  Ser Gln Gln Glu Thr  Thr Val Lys 
    2180                 2185                 2190             


Gln Leu  Gln Ser Pro Leu Pro  Leu Pro Thr Thr Leu  Pro Leu Leu 
    2195                 2200                 2205             


Ser Ala  Ser Ile Ala Ser Thr  Lys Thr Val Ile Ala  Asn Pro Val 
    2210                 2215                 2220             


Leu Tyr  Leu Asn Asn His Ile  His Asp Ile Leu Tyr  Thr Ile Val 
    2225                 2230                 2235             


Gln Met  Lys Thr Pro Pro His  Pro Ser Ile Glu Asp  Val Lys Val 
    2240                 2245                 2250             


His Thr  Leu His Ser Leu Ala  Ala Ser Leu Ser Ala  Ser Ile Tyr 
    2255                 2260                 2265             


Gln Ala  Leu Cys Asp Ser His  Ser Tyr Ser Ser Gln  Thr Glu Gly 
    2270                 2275                 2280             


Asn Gln  Phe Thr Gly Met Ala  Tyr Gln Gly Leu Leu  Leu Ser Asp 
    2285                 2290                 2295             


Arg Arg  Arg Leu Arg Thr Glu  Ser Ile Glu Glu His  Ala Thr Pro 
    2300                 2305                 2310             


Asn Ser  Ser Pro Ala Gln Trp  Pro Gly Val Ser Ser  Leu Ile Asn 
    2315                 2320                 2325             


Leu Leu  Ser Ser Ala Gln Asp  Glu Asp Gln Pro Lys  Leu Asn Ile 
    2330                 2335                 2340             


Leu Leu  Cys Glu Ala Val Val  Ala Val Tyr Leu Ser  Leu Leu Ile 
    2345                 2350                 2355             


His Ala  Leu Ala Thr Asn Ser  Ser Ser Glu Leu Phe  Arg Leu Ala 
    2360                 2365                 2370             


Ala His  Pro Leu Asn Asn Arg  Met Trp Ala Ala Val  Phe Gly Gly 
    2375                 2380                 2385             


Gly Val  Lys Leu Val Val Lys  Pro Arg Arg Gln Ser  Glu Asn Ile 
    2390                 2395                 2400             


Ser Ala  Pro Pro Val Leu Ser  Glu Asp Ile Asp Lys  His Arg Arg 
    2405                 2410                 2415             


Arg Phe  Asn Met Arg Met Leu  Val Pro Gly Arg Pro  Val Lys Asp 
    2420                 2425                 2430             


Ala Thr  Pro Pro Pro Val Pro  Ala Glu Arg Pro Ser  Tyr Lys Glu 
    2435                 2440                 2445             


Lys Phe  Ile Pro Pro Glu Leu  Ser Met Trp Asp Tyr  Phe Val Ala 
    2450                 2455                 2460             


Lys Pro  Phe Leu Pro Leu Ser  Asp Ser Gly Val Ile  Tyr Asp Ser 
    2465                 2470                 2475             


Asp Glu  Ser Ile His Ser Asp  Glu Glu Asp Asp Ala  Phe Phe Ser 
    2480                 2485                 2490             


Asp Thr  Gln Ile Gln Glu His  Gln Asp Pro Asn Ser  Tyr Ser Trp 
    2495                 2500                 2505             


Ala Leu  Leu His Leu Thr Met  Val Lys Leu Ala Leu  His Asn Val 
    2510                 2515                 2520             


Lys Asn  Phe Phe Pro Ile Ala  Gly Leu Glu Phe Ser  Glu Leu Pro 
    2525                 2530                 2535             


Val Thr  Ser Pro Leu Gly Ile  Ala Val Ile Lys Asn  Leu Glu Asn 
    2540                 2545                 2550             


Trp Glu  Gln Ile Leu Gln Glu  Lys Met Asp Gln Phe  Glu Gly Pro 
    2555                 2560                 2565             


Pro Pro  Asn Tyr Ile Asn Thr  Tyr Pro Thr Asp Leu  Ser Val Gly 
    2570                 2575                 2580             


Ala Gly  Pro Ala Ile Leu Arg  Asn Lys Ala Met Leu  Glu Pro Glu 
    2585                 2590                 2595             


Asn Thr  Pro Phe Lys Ser Arg  Asp Ser Ser Ala Phe  Pro Val Lys 
    2600                 2605                 2610             


Arg Leu  Trp His Phe Leu Val  Lys Gln Glu Val Leu  Gln Glu Thr 
    2615                 2620                 2625             


Phe Ile  Arg Tyr Ile Phe Thr  Lys Lys Arg Lys Gln  Ser Glu Val 
    2630                 2635                 2640             


Glu Ala  Asp Leu Gly Tyr Pro  Gly Gly Lys Ala Lys  Val Ile His 
    2645                 2650                 2655             


Lys Glu  Ser Asp Met Ile Met  Ala Phe Ser Val Asn  Lys Ala Asn 
    2660                 2665                 2670             


Cys Asn  Glu Ile Val Leu Ala  Ser Thr His Asp Val  Gln Glu Leu 
    2675                 2680                 2685             


Asp Val  Thr Ser Leu Leu Ala  Cys Gln Ser Tyr Ile  Trp Ile Gly 
    2690                 2695                 2700             


Glu Glu  Tyr Asp Arg Glu Ser  Lys Ser Ser Asp Asp  Val Asp Tyr 
    2705                 2710                 2715             


Arg Gly  Ser Thr Thr Thr Leu  Tyr Gln Pro Ser Ala  Thr Ser Tyr 
    2720                 2725                 2730             


Ser Ala  Ser Gln Val His Pro  Pro Ser Ser Leu Pro  Trp Leu Gly 
    2735                 2740                 2745             


Thr Gly  Gln Thr Ser Thr Gly  Ala Ser Val Leu Met  Lys Arg Asn 
    2750                 2755                 2760             


Leu His  Asn Val Lys Arg Met  Thr Ser His Pro Val  His Gln Tyr 
    2765                 2770                 2775             


Tyr Leu  Thr Gly Ala Gln Asp  Gly Ser Val Arg Met  Phe Glu Trp 
    2780                 2785                 2790             


Thr Arg  Pro Gln Gln Leu Val  Cys Phe Arg Gln Ala  Gly Asn Ala 
    2795                 2800                 2805             


Arg Val  Thr Arg Leu Tyr Phe  Asn Ser Gln Gly Asn  Lys Cys Gly 
    2810                 2815                 2820             


Val Ala  Asp Gly Glu Gly Phe  Leu Ser Ile Trp Gln  Val Asn Gln 
    2825                 2830                 2835             


Thr Ala  Ser Asn Pro Lys Pro  Tyr Met Ser Trp Gln  Cys His Ser 
    2840                 2845                 2850             


Lys Ala  Thr Ser Asp Phe Ala  Phe Ile Thr Ser Ser  Ser Leu Val 
    2855                 2860                 2865             


Ala Thr  Ser Gly His Ser Asn  Asp Asn Arg Asn Val  Cys Leu Trp 
    2870                 2875                 2880             


Asp Thr  Leu Ile Ser Pro Gly  Asn Ser Leu Ile His  Gly Phe Thr 
    2885                 2890                 2895             


Cys His  Asp His Gly Ala Thr  Val Leu Gln Tyr Ala  Pro Lys Gln 
    2900                 2905                 2910             


Gln Leu  Leu Ile Ser Gly Gly  Arg Lys Gly His Val  Cys Ile Phe 
    2915                 2920                 2925             


Asp Ile  Arg Gln Arg Gln Leu  Ile His Thr Phe Gln  Ala His Asp 
    2930                 2935                 2940             


Ser Ala  Ile Lys Ala Leu Ala  Leu Asp Pro Tyr Glu  Glu Tyr Phe 
    2945                 2950                 2955             


Thr Thr  Gly Ser Ala Glu Gly  Asn Ile Lys Val Trp  Arg Leu Thr 
    2960                 2965                 2970             


Gly His  Gly Leu Ile His Ser  Phe Lys Ser Glu His  Ala Lys Gln 
    2975                 2980                 2985             


Ser Ile  Phe Arg Asn Ile Gly  Ala Gly Val Met Gln  Ile Asp Ile 
    2990                 2995                 3000             


Ile Gln  Gly Asn Arg Leu Phe  Ser Cys Gly Ala Asp  Gly Thr Leu 
    3005                 3010                 3015             


Lys Thr  Arg Val Leu Pro Asn  Ala Phe Asn Ile Pro  Asn Arg Ile 
    3020                 3025                 3030             


Leu Asp  Ile Leu 
    3035         


<210>  3133
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNA2__Homo_sapiens__NP_001073918

<400>  3133

Met Glu Gln Leu Asn Glu Leu Glu Leu Leu Met Glu Lys Ser Phe Trp 
1               5                   10                  15      


Glu Glu Ala Glu Leu Pro Ala Glu Leu Phe Gln Lys Lys Val Val Ala 
            20                  25                  30          


Ser Phe Pro Arg Thr Val Leu Ser Thr Gly Met Asp Asn Arg Tyr Leu 
        35                  40                  45              


Val Leu Ala Val Asn Thr Val Gln Asn Lys Glu Gly Asn Cys Glu Lys 
    50                  55                  60                  


Arg Leu Val Ile Thr Ala Ser Gln Ser Leu Glu Asn Lys Glu Leu Cys 
65                  70                  75                  80  


Ile Leu Arg Asn Asp Trp Cys Ser Val Pro Val Glu Pro Gly Asp Ile 
                85                  90                  95      


Ile His Leu Glu Gly Asp Cys Thr Ser Asp Thr Trp Ile Ile Asp Lys 
            100                 105                 110         


Asp Phe Gly Tyr Leu Ile Leu Tyr Pro Asp Met Leu Ile Ser Gly Thr 
        115                 120                 125             


Ser Ile Ala Ser Ser Ile Arg Cys Met Arg Arg Ala Val Leu Ser Glu 
    130                 135                 140                 


Thr Phe Arg Ser Ser Asp Pro Ala Thr Arg Gln Met Leu Ile Gly Thr 
145                 150                 155                 160 


Val Leu His Glu Val Phe Gln Lys Ala Ile Asn Asn Ser Phe Ala Pro 
                165                 170                 175     


Glu Lys Leu Gln Glu Leu Ala Phe Gln Thr Ile Gln Glu Ile Arg His 
            180                 185                 190         


Leu Lys Glu Met Tyr Arg Leu Asn Leu Ser Gln Asp Glu Ile Lys Gln 
        195                 200                 205             


Glu Val Glu Asp Tyr Leu Pro Ser Phe Cys Lys Trp Ala Gly Asp Phe 
    210                 215                 220                 


Met His Lys Asn Thr Ser Thr Asp Phe Pro Gln Met Gln Leu Ser Leu 
225                 230                 235                 240 


Pro Ser Asp Asn Ser Lys Asp Asn Ser Thr Cys Asn Ile Glu Val Val 
                245                 250                 255     


Lys Pro Met Asp Ile Glu Glu Ser Ile Trp Ser Pro Arg Phe Gly Leu 
            260                 265                 270         


Lys Gly Lys Ile Asp Val Thr Val Gly Val Lys Ile His Arg Gly Tyr 
        275                 280                 285             


Lys Thr Lys Tyr Lys Ile Met Pro Leu Glu Leu Lys Thr Gly Lys Glu 
    290                 295                 300                 


Ser Asn Ser Ile Glu His Arg Ser Gln Val Val Leu Tyr Thr Leu Leu 
305                 310                 315                 320 


Ser Gln Glu Arg Arg Ala Asp Pro Glu Ala Gly Leu Leu Leu Tyr Leu 
                325                 330                 335     


Lys Thr Gly Gln Met Tyr Pro Val Pro Ala Asn His Leu Asp Lys Arg 
            340                 345                 350         


Glu Leu Leu Lys Leu Arg Asn Gln Met Ala Phe Ser Leu Phe His Arg 
        355                 360                 365             


Ile Ser Lys Ser Ala Thr Arg Gln Lys Thr Gln Leu Ala Ser Leu Pro 
    370                 375                 380                 


Gln Ile Ile Glu Glu Glu Lys Thr Cys Lys Tyr Cys Ser Gln Ile Gly 
385                 390                 395                 400 


Asn Cys Ala Leu Tyr Ser Arg Ala Val Glu Gln Gln Met Asp Cys Ser 
                405                 410                 415     


Ser Val Pro Ile Val Met Leu Pro Lys Ile Glu Glu Glu Thr Gln His 
            420                 425                 430         


Leu Lys Gln Thr His Leu Glu Tyr Phe Ser Leu Trp Cys Leu Met Leu 
        435                 440                 445             


Thr Leu Glu Ser Gln Ser Lys Asp Asn Lys Lys Asn His Gln Asn Ile 
    450                 455                 460                 


Trp Leu Met Pro Ala Ser Glu Met Glu Lys Ser Gly Ser Cys Ile Gly 
465                 470                 475                 480 


Asn Leu Ile Arg Met Glu His Val Lys Ile Val Cys Asp Gly Gln Tyr 
                485                 490                 495     


Leu His Asn Phe Gln Cys Lys His Gly Ala Ile Pro Val Thr Asn Leu 
            500                 505                 510         


Met Ala Gly Asp Arg Val Ile Val Ser Gly Glu Glu Arg Ser Leu Phe 
        515                 520                 525             


Ala Leu Ser Arg Gly Tyr Val Lys Glu Ile Asn Met Thr Thr Val Thr 
    530                 535                 540                 


Cys Leu Leu Asp Arg Asn Leu Ser Val Leu Pro Glu Ser Thr Leu Phe 
545                 550                 555                 560 


Arg Leu Asp Gln Glu Glu Lys Asn Cys Asp Ile Asp Thr Pro Leu Gly 
                565                 570                 575     


Asn Leu Ser Lys Leu Met Glu Asn Thr Phe Val Ser Lys Lys Leu Arg 
            580                 585                 590         


Asp Leu Ile Ile Asp Phe Arg Glu Pro Gln Phe Ile Ser Tyr Leu Ser 
        595                 600                 605             


Ser Val Leu Pro His Asp Ala Lys Asp Thr Val Ala Cys Ile Leu Lys 
    610                 615                 620                 


Gly Leu Asn Lys Pro Gln Arg Gln Ala Met Lys Lys Val Leu Leu Ser 
625                 630                 635                 640 


Lys Asp Tyr Thr Leu Ile Val Gly Met Pro Gly Thr Gly Lys Thr Thr 
                645                 650                 655     


Thr Ile Cys Thr Leu Val Arg Ile Leu Tyr Ala Cys Gly Phe Ser Val 
            660                 665                 670         


Leu Leu Thr Ser Tyr Thr His Ser Ala Val Asp Asn Ile Leu Leu Lys 
        675                 680                 685             


Leu Ala Lys Phe Lys Ile Gly Phe Leu Arg Leu Gly Gln Ile Gln Lys 
    690                 695                 700                 


Val His Pro Ala Ile Gln Gln Phe Thr Glu Gln Glu Ile Cys Arg Ser 
705                 710                 715                 720 


Lys Ser Ile Lys Ser Leu Ala Leu Leu Glu Glu Leu Tyr Asn Ser Gln 
                725                 730                 735     


Leu Ile Val Ala Thr Thr Cys Met Gly Ile Asn His Pro Ile Phe Ser 
            740                 745                 750         


Arg Lys Ile Phe Asp Phe Cys Ile Val Asp Glu Ala Ser Gln Ile Ser 
        755                 760                 765             


Gln Pro Ile Cys Leu Gly Pro Leu Phe Phe Ser Arg Arg Phe Val Leu 
    770                 775                 780                 


Val Gly Asp His Gln Gln Leu Pro Pro Leu Val Leu Asn Arg Glu Ala 
785                 790                 795                 800 


Arg Ala Leu Gly Met Ser Glu Ser Leu Phe Lys Arg Leu Glu Gln Asn 
                805                 810                 815     


Lys Ser Ala Val Val Gln Leu Thr Val Gln Tyr Arg Met Asn Ser Lys 
            820                 825                 830         


Ile Met Ser Leu Ser Asn Lys Leu Thr Tyr Glu Gly Lys Leu Glu Cys 
        835                 840                 845             


Gly Ser Asp Lys Val Ala Asn Ala Val Ile Asn Leu Arg His Phe Lys 
    850                 855                 860                 


Asp Val Lys Leu Glu Leu Glu Phe Tyr Ala Asp Tyr Ser Asp Asn Pro 
865                 870                 875                 880 


Trp Leu Met Gly Val Phe Glu Pro Asn Asn Pro Val Cys Phe Leu Asn 
                885                 890                 895     


Thr Asp Lys Val Pro Ala Pro Glu Gln Val Glu Lys Gly Gly Val Ser 
            900                 905                 910         


Asn Val Thr Glu Ala Lys Leu Ile Val Phe Leu Thr Ser Ile Phe Val 
        915                 920                 925             


Lys Ala Gly Cys Ser Pro Ser Asp Ile Gly Ile Ile Ala Pro Tyr Arg 
    930                 935                 940                 


Gln Gln Leu Lys Ile Ile Asn Asp Leu Leu Ala Arg Ser Ile Gly Met 
945                 950                 955                 960 


Val Glu Val Asn Thr Val Asp Lys Tyr Gln Gly Arg Asp Lys Ser Ile 
                965                 970                 975     


Val Leu Val Ser Phe Val Arg Ser Asn Lys Asp Gly Thr Val Gly Glu 
            980                 985                 990         


Leu Leu Lys Asp Trp Arg Arg Leu  Asn Val Ala Ile Thr  Arg Ala Lys 
        995                 1000                 1005             


His Lys  Leu Ile Leu Leu Gly  Cys Val Pro Ser Leu  Asn Cys Tyr 
    1010                 1015                 1020             


Pro Pro  Leu Glu Lys Leu Leu  Asn His Leu Asn Ser  Glu Lys Leu 
    1025                 1030                 1035             


Ile Ile  Asp Leu Pro Ser Arg  Glu His Glu Ser Leu  Cys His Ile 
    1040                 1045                 1050             


Leu Gly  Asp Phe Gln Arg Glu  
    1055                 1060 


<210>  3134
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAAF1__Homo_sapiens__NP_848547

<400>  3134

Met His Pro Glu Pro Ser Glu Pro Ala Thr Gly Gly Ala Ala Glu Leu 
1               5                   10                  15      


Asp Cys Ala Gln Glu Pro Gly Val Glu Glu Ser Ala Gly Asp His Gly 
            20                  25                  30          


Ser Ala Gly Arg Gly Gly Cys Lys Glu Glu Ile Asn Asp Pro Lys Glu 
        35                  40                  45              


Ile Cys Val Gly Ser Ser Asp Thr Ser Tyr His Ser Gln Gln Lys Gln 
    50                  55                  60                  


Ser Gly Asp Asn Gly Ser Gly Gly His Phe Ala His Pro Arg Glu Asp 
65                  70                  75                  80  


Arg Glu Asp Arg Gly Pro Arg Met Thr Lys Ser Ser Leu Gln Lys Leu 
                85                  90                  95      


Cys Lys Gln His Lys Leu Tyr Ile Thr Pro Ala Leu Asn Asp Thr Leu 
            100                 105                 110         


Tyr Leu His Phe Lys Gly Phe Asp Arg Ile Glu Asn Leu Glu Glu Tyr 
        115                 120                 125             


Thr Gly Leu Arg Cys Leu Trp Leu Gln Ser Asn Gly Ile Gln Lys Ile 
    130                 135                 140                 


Glu Asn Leu Glu Ala Gln Thr Glu Leu Arg Cys Leu Phe Leu Gln Met 
145                 150                 155                 160 


Asn Leu Leu Arg Lys Ile Glu Asn Leu Glu Pro Leu Gln Lys Leu Asp 
                165                 170                 175     


Ala Leu Asn Leu Ser Asn Asn Tyr Ile Lys Thr Ile Glu Asn Leu Ser 
            180                 185                 190         


Cys Leu Pro Val Leu Asn Thr Leu Gln Met Ala His Asn His Leu Glu 
        195                 200                 205             


Thr Val Glu Asp Ile Gln His Leu Gln Glu Cys Leu Arg Leu Cys Val 
    210                 215                 220                 


Leu Asp Leu Ser His Asn Lys Leu Ser Asp Pro Glu Ile Leu Ser Ile 
225                 230                 235                 240 


Leu Glu Ser Met Pro Asp Leu Arg Val Leu Asn Leu Met Gly Asn Pro 
                245                 250                 255     


Val Ile Arg Gln Ile Pro Asn Tyr Arg Arg Thr Val Thr Val Arg Leu 
            260                 265                 270         


Lys His Leu Thr Tyr Leu Asp Asp Arg Pro Val Phe Pro Lys Asp Arg 
        275                 280                 285             


Ala Cys Ala Glu Ala Trp Ala Arg Gly Gly Tyr Ala Ala Glu Lys Glu 
    290                 295                 300                 


Glu Arg Gln Gln Trp Glu Ser Arg Glu Arg Lys Lys Ile Thr Asp Ser 
305                 310                 315                 320 


Ile Glu Ala Leu Ala Met Ile Lys Gln Arg Ala Glu Glu Arg Lys Arg 
                325                 330                 335     


Gln Arg Glu Ser Gln Glu Arg Gly Glu Met Thr Ser Ser Asp Asp Gly 
            340                 345                 350         


Glu Asn Val Pro Ala Ser Ala Glu Gly Lys Glu Glu Pro Pro Gly Asp 
        355                 360                 365             


Arg Glu Thr Arg Gln Lys Met Glu Leu Phe Val Lys Glu Ser Phe Glu 
    370                 375                 380                 


Ala Lys Asp Glu Leu Cys Pro Glu Lys Pro Ser Gly Glu Glu Pro Pro 
385                 390                 395                 400 


Val Glu Ala Lys Arg Glu Asp Gly Gly Pro Glu Pro Glu Gly Thr Leu 
                405                 410                 415     


Pro Ala Glu Thr Leu Leu Leu Ser Ser Pro Val Glu Val Lys Gly Glu 
            420                 425                 430         


Asp Gly Asp Gly Glu Pro Glu Gly Thr Leu Pro Ala Glu Ala Pro Pro 
        435                 440                 445             


Pro Pro Pro Pro Val Glu Val Lys Gly Glu Asp Gly Asp Gln Glu Pro 
    450                 455                 460                 


Glu Gly Thr Leu Pro Ala Glu Thr Leu Leu Leu Ser Pro Pro Val Lys 
465                 470                 475                 480 


Val Lys Gly Glu Asp Gly Asp Arg Glu Pro Glu Gly Thr Leu Pro Ala 
                485                 490                 495     


Glu Ala Pro Pro Pro Pro Pro Leu Gly Ala Ala Arg Glu Glu Pro Thr 
            500                 505                 510         


Pro Gln Ala Val Ala Thr Glu Gly Val Phe Val Thr Glu Leu Asp Gly 
        515                 520                 525             


Thr Arg Thr Glu Asp Leu Glu Thr Ile Arg Leu Glu Thr Lys Glu Thr 
    530                 535                 540                 


Phe Cys Ile Asp Asp Leu Pro Asp Leu Glu Asp Asp Asp Glu Thr Gly 
545                 550                 555                 560 


Lys Ser Leu Glu Asp Gln Asn Met Cys Phe Pro Lys Ile Glu Val Ile 
                565                 570                 575     


Ser Ser Leu Ser Asp Asp Ser Asp Pro Glu Leu Asp Tyr Thr Ser Leu 
            580                 585                 590         


Pro Val Leu Glu Asn Leu Pro Thr Asp Thr Leu Ser Asn Ile Phe Ala 
        595                 600                 605             


Val Ser Lys Asp Thr Ser Lys Ala Ala Arg Val Pro Phe Thr Asp Ile 
    610                 615                 620                 


Phe Lys Lys Glu Ala Lys Arg Asp Leu Glu Ile Arg Lys Gln Asp Thr 
625                 630                 635                 640 


Lys Ser Pro Arg Pro Leu Ile Gln Glu Leu Ser Asp Glu Asp Pro Ser 
                645                 650                 655     


Gly Gln Leu Leu Met Pro Pro Thr Cys Gln Arg Asp Ala Ala Pro Leu 
            660                 665                 670         


Thr Ser Ser Gly Asp Arg Asp Ser Asp Phe Leu Ala Ala Ser Ser Pro 
        675                 680                 685             


Val Pro Thr Glu Ser Ala Ala Thr Pro Pro Glu Thr Cys Val Gly Val 
    690                 695                 700                 


Ala Gln Pro Ser Gln Ala Leu Pro Thr Trp Asp Leu Thr Ala Phe Pro 
705                 710                 715                 720 


Ala Pro Lys Ala Ser 
                725 


<210>  3135
<211>  789
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAAF2__Homo_sapiens__NP_001077377

<400>  3135

Met Ala Lys Ala Ala Ala Ser Ser Ser Leu Glu Asp Leu Asp Leu Ser 
1               5                   10                  15      


Gly Glu Glu Val Gln Arg Leu Thr Ser Ala Phe Gln Asp Pro Glu Phe 
            20                  25                  30          


Arg Arg Met Phe Ser Gln Tyr Ala Glu Glu Leu Thr Asp Pro Glu Asn 
        35                  40                  45              


Arg Arg Arg Tyr Glu Ala Glu Ile Thr Ala Leu Glu Arg Glu Arg Gly 
    50                  55                  60                  


Val Glu Val Arg Phe Val His Pro Glu Pro Gly His Val Leu Arg Thr 
65                  70                  75                  80  


Ser Leu Asp Gly Ala Arg Arg Cys Phe Val Asn Val Cys Ser Asn Ala 
                85                  90                  95      


Leu Val Gly Ala Pro Ser Ser Arg Pro Gly Ser Gly Gly Asp Arg Gly 
            100                 105                 110         


Ala Ala Pro Gly Ser His Trp Ser Leu Pro Tyr Ser Leu Ala Pro Gly 
        115                 120                 125             


Arg Glu Tyr Ala Gly Arg Ser Ser Ser Arg Tyr Met Val Tyr Asp Val 
    130                 135                 140                 


Val Phe His Pro Asp Ala Leu Ala Leu Ala Arg Arg His Glu Gly Phe 
145                 150                 155                 160 


Arg Gln Met Leu Asp Ala Thr Ala Leu Glu Ala Val Glu Lys Gln Phe 
                165                 170                 175     


Gly Val Lys Leu Asp Arg Arg Asn Ala Lys Thr Leu Lys Ala Lys Tyr 
            180                 185                 190         


Lys Gly Thr Pro Glu Ala Ala Val Leu Arg Thr Pro Leu Pro Gly Val 
        195                 200                 205             


Ile Pro Ala Arg Pro Asp Gly Glu Pro Lys Gly Pro Leu Pro Asp Phe 
    210                 215                 220                 


Pro Tyr Pro Tyr Gln Tyr Pro Ala Ala Pro Gly Pro Arg Ala Pro Ser 
225                 230                 235                 240 


Pro Pro Glu Ala Ala Leu Gln Pro Ala Pro Thr Glu Pro Arg Tyr Ser 
                245                 250                 255     


Val Val Gln Arg His His Val Asp Leu Gln Asp Tyr Arg Cys Ser Arg 
            260                 265                 270         


Asp Ser Ala Pro Ser Pro Val Pro His Glu Leu Val Ile Thr Ile Glu 
        275                 280                 285             


Leu Pro Leu Leu Arg Ser Ala Glu Gln Ala Ala Leu Glu Val Thr Arg 
    290                 295                 300                 


Lys Leu Leu Cys Leu Asp Ser Arg Lys Pro Asp Tyr Arg Leu Arg Leu 
305                 310                 315                 320 


Ser Leu Pro Tyr Pro Val Asp Asp Gly Arg Gly Lys Ala Gln Phe Asn 
                325                 330                 335     


Lys Ala Arg Arg Gln Leu Val Val Thr Leu Pro Val Val Leu Pro Ala 
            340                 345                 350         


Ala Arg Arg Glu Pro Ala Val Ala Val Ala Ala Ala Ala Pro Glu Glu 
        355                 360                 365             


Ser Ala Asp Arg Ser Gly Thr Asp Gly Gln Ala Cys Ala Ser Ala Arg 
    370                 375                 380                 


Glu Gly Glu Ala Gly Pro Ala Arg Ser Arg Ala Glu Asp Gly Gly His 
385                 390                 395                 400 


Asp Thr Cys Val Ala Gly Ala Ala Gly Ser Gly Val Thr Thr Leu Gly 
                405                 410                 415     


Asp Pro Glu Val Ala Pro Pro Pro Ala Ala Ala Gly Glu Glu Arg Val 
            420                 425                 430         


Pro Lys Pro Gly Glu Gln Asp Leu Ser Arg His Ala Gly Ser Pro Pro 
        435                 440                 445             


Gly Ser Val Glu Glu Pro Ser Pro Gly Gly Glu Asn Ser Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Pro Cys Leu Ser Ser Arg Ser Leu Ala Trp Gly Ser Ser 
465                 470                 475                 480 


Ala Gly Arg Glu Ser Ala Arg Gly Asp Ser Ser Val Glu Thr Arg Glu 
                485                 490                 495     


Glu Ser Glu Gly Thr Gly Gly Gln Arg Ser Ala Cys Ala Met Gly Gly 
            500                 505                 510         


Pro Gly Thr Lys Ser Gly Glu Pro Leu Cys Pro Pro Leu Leu Cys Asn 
        515                 520                 525             


Gln Asp Lys Glu Thr Leu Thr Leu Leu Ile Gln Val Pro Arg Ile Gln 
    530                 535                 540                 


Pro Gln Ser Leu Gln Gly Asp Leu Asn Pro Leu Trp Tyr Lys Leu Arg 
545                 550                 555                 560 


Phe Ser Ala Gln Asp Leu Val Tyr Ser Phe Phe Leu Gln Phe Ala Pro 
                565                 570                 575     


Glu Asn Lys Leu Ser Thr Thr Glu Pro Val Ile Ser Ile Ser Ser Asn 
            580                 585                 590         


Asn Ala Val Ile Glu Leu Ala Lys Ser Pro Glu Ser His Gly His Trp 
        595                 600                 605             


Arg Glu Trp Tyr Tyr Gly Val Asn Asn Asp Ser Leu Glu Leu Gln Glu 
    610                 615                 620                 


Cys Ser Asn Ser Asp Gln Leu Gln Gly Lys Glu Glu Arg Val Asn Glu 
625                 630                 635                 640 


Glu Ser His Leu Thr Glu Lys Glu Tyr Ile Glu His Cys Asn Thr Pro 
                645                 650                 655     


Thr Thr Asp Ser Asp Ser Ser Ile Ala Val Lys Ala Leu Gln Ile Asp 
            660                 665                 670         


Ser Phe Gly Leu Val Thr Cys Phe Gln Gln Glu Ser Leu Asp Val Ser 
        675                 680                 685             


Gln Met Ile Leu Gly Lys Ser Gln Gln Pro Glu Ser Lys Met Gln Ser 
    690                 695                 700                 


Glu Phe Ile Lys Glu Lys Ser Ala Thr Cys Ser Asn Glu Glu Lys Asp 
705                 710                 715                 720 


Asn Leu Asn Glu Ser Val Ile Thr Glu Glu Lys Glu Thr Asp Gly Asp 
                725                 730                 735     


His Leu Ser Ser Leu Leu Asn Lys Thr Thr Val His Asn Ile Pro Gly 
            740                 745                 750         


Phe Asp Ser Ile Lys Glu Thr Asn Met Gln Asp Gly Ser Val Gln Val 
        755                 760                 765             


Ile Lys Asp His Val Thr Asn Cys Ala Phe Ser Phe Gln Asn Ser Leu 
    770                 775                 780                 


Leu Tyr Asp Leu Asp 
785                 


<210>  3136
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAAF3__Homo_sapiens__NP_001243643

<400>  3136

Met Leu Pro Leu Leu Asp Ser Ser Lys Arg Ala Gly Thr Leu Gly Ser 
1               5                   10                  15      


Gly Cys Gly Val Pro Arg Val His Ser Ala Ala Leu Ser Arg Glu Glu 
            20                  25                  30          


Gly Ala Ser Arg Asp Ile Trp Arg Ile Lys Val Trp Ala Arg Val Met 
        35                  40                  45              


Thr Thr Pro Ala Gly Ser Gly Ser Gly Phe Gly Ser Val Ser Trp Trp 
    50                  55                  60                  


Gly Leu Ser Pro Ala Leu Asp Leu Gln Ala Glu Arg Asp Ala Thr Val 
65                  70                  75                  80  


Asp Ala Leu Pro Thr Thr Met Val Pro Gln Pro Ala Val Ile Leu Pro 
                85                  90                  95      


Gly Pro Pro Val Asp Pro Asp Ser Gln Ala Asp Thr Val His Ser Asn 
            100                 105                 110         


Pro Glu Leu Asp Val Leu Leu Leu Gly Ser Val Asp Gly Arg His Leu 
        115                 120                 125             


Leu Arg Thr Leu Ser Arg Ala Lys Phe Trp Pro Arg Arg Arg Phe Asn 
    130                 135                 140                 


Phe Phe Val Leu Glu Asn Asn Leu Glu Ala Val Ala Arg His Met Leu 
145                 150                 155                 160 


Ile Phe Ser Leu Ala Leu Glu Glu Pro Glu Lys Met Gly Leu Gln Glu 
                165                 170                 175     


Arg Ser Glu Thr Phe Leu Glu Val Trp Gly Asn Ala Leu Leu Arg Pro 
            180                 185                 190         


Pro Val Ala Ala Phe Val Arg Ala Gln Ala Asp Leu Leu Ala His Leu 
        195                 200                 205             


Val Pro Glu Pro Asp Arg Leu Glu Glu Gln Leu Pro Trp Leu Ser Leu 
    210                 215                 220                 


Arg Ala Leu Lys Phe Arg Glu Arg Asp Ala Leu Glu Ala Val Phe Arg 
225                 230                 235                 240 


Phe Trp Ala Gly Gly Glu Lys Gly Pro Gln Ala Phe Pro Met Ser Arg 
                245                 250                 255     


Leu Trp Asp Ser Arg Leu Arg His Tyr Leu Gly Ser Arg Tyr Asp Ala 
            260                 265                 270         


Arg Arg Gly Val Ser Asp Trp Asp Leu Arg Met Lys Leu His Asp Arg 
        275                 280                 285             


Gly Ala Gln Val Ile His Pro Gln Glu Phe Arg Arg Trp Arg Asp Thr 
    290                 295                 300                 


Gly Val Ala Phe Glu Leu Arg Asp Ser Ser Ala Tyr His Val Pro Asn 
305                 310                 315                 320 


Arg Thr Leu Ala Ser Gly Arg Leu Leu Ser Tyr Arg Gly Glu Arg Val 
                325                 330                 335     


Ala Ala Arg Gly Tyr Trp Gly Asp Ile Ala Thr Gly Pro Phe Val Ala 
            340                 345                 350         


Phe Gly Ile Glu Ala Asp Asp Glu Ser Leu Leu Arg Thr Ser Asn Gly 
        355                 360                 365             


Gln Pro Val Lys Thr Ala Gly Glu Ile Thr Gln His Asn Val Thr Glu 
    370                 375                 380                 


Leu Leu Arg Asp Val Ala Ala Trp Gly Arg Ala Arg Ala Thr Gly Gly 
385                 390                 395                 400 


Asp Leu Glu Glu Gln Gln His Ala Glu Gly Ser Pro Glu Pro Gly Thr 
                405                 410                 415     


Pro Ala Pro Thr Pro Glu Ser Phe Thr Val His Phe Leu Pro Leu Asn 
            420                 425                 430         


Ser Ala Gln Thr Leu His His Lys Ser Cys Tyr Asn Gly Arg Phe Gln 
        435                 440                 445             


Leu Leu Tyr Val Ala Cys Gly Met Val His Leu Leu Ile Pro Glu Leu 
    450                 455                 460                 


Gly Ala Cys Val Ala Pro Gly Gly Asn Leu Ile Val Glu Leu Ala Arg 
465                 470                 475                 480 


Tyr Leu Val Asp Val Arg Gln Glu Gln Leu Gln Gly Phe Asn Thr Arg 
                485                 490                 495     


Val Arg Glu Leu Ala Gln Ala Ala Gly Phe Ala Pro Gln Thr Gly Ala 
            500                 505                 510         


Arg Pro Ser Glu Thr Phe Ala Arg Phe Cys Lys Ser Gln Glu Ser Ala 
        515                 520                 525             


Leu Gly Asn Thr Val Pro Ala Val Glu Pro Gly Thr Pro Pro Leu Asp 
    530                 535                 540                 


Ile Leu Ala Gln Pro Leu Glu Ala Ser Asn Pro Ala Leu Glu Gly Leu 
545                 550                 555                 560 


Thr Gln Pro Leu Gln Gly Gly Thr Pro His Cys Glu Pro Cys Gln Leu 
                565                 570                 575     


Pro Ser Glu Ser Pro Gly Ser Leu Ser Glu Val Leu Ala Gln Pro Gln 
            580                 585                 590         


Gly Ala Leu Ala Pro Pro Asn Cys Glu Ser Asp Ser Lys Thr Gly Val 
        595                 600                 605             


<210>  3137
<211>  855
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAAF5__Homo_sapiens__NP_060272

<400>  3137

Met Ala Ala Leu Gly Val Ala Glu Ala Val Ala Ala Pro His Pro Ala 
1               5                   10                  15      


Glu Gly Ala Glu Thr Ala Glu Ala Val Glu Leu Ser Arg Ala Leu Ser 
            20                  25                  30          


Arg Leu Leu Pro Gly Leu Glu Ala Asp Ser Lys Pro Gly Arg Arg Arg 
        35                  40                  45              


Ala Leu Glu Ala Leu Arg Arg Ala Leu Glu Glu Pro Gly Pro Ala Ala 
    50                  55                  60                  


Asp Pro Thr Ala Phe Gln Gly Pro Trp Ala Arg Leu Leu Leu Pro Arg 
65                  70                  75                  80  


Leu Leu Arg Cys Leu Ser Asp Pro Ala Glu Gly Cys Arg Ala Leu Ala 
                85                  90                  95      


Val His Leu Leu Asp Leu Gly Leu Arg Arg Ala Ala Arg Pro Arg Asp 
            100                 105                 110         


Ala Leu Pro Arg Leu Leu Pro Ala Leu Ala Ala Arg Leu Ala Gly Pro 
        115                 120                 125             


Val Pro Ala Arg Arg Pro Pro Glu Ala Cys Glu Glu Leu Arg Leu Ala 
    130                 135                 140                 


Leu Val Gln Leu Leu Gly Leu Ala Val Asp Leu Cys Gly Ala Ala Leu 
145                 150                 155                 160 


Ala Pro His Leu Asp Asp Ala Leu Arg Ala Leu Arg Cys Ser Leu Leu 
                165                 170                 175     


Asp Pro Phe Ala Ala Val Arg Arg Glu Ser Cys Ser Cys Ala Ala Ala 
            180                 185                 190         


Leu Ala Gln Ala Thr Pro Asp His Phe His Met Gln Ser Glu Ser Leu 
        195                 200                 205             


Ile Gly Pro Leu Met Gln Thr Ile Ser His Gln His Trp Lys Val Arg 
    210                 215                 220                 


Val Ala Ala Ile Glu Ala Thr Gly Ala Val Ile His Phe Gly Asn Gly 
225                 230                 235                 240 


Lys Ser Val Asp Asp Val Leu Ser His Phe Ala Gln Arg Leu Phe Asp 
                245                 250                 255     


Asp Val Pro Gln Val Arg Arg Ala Val Ala Ser Val Val Gly Gly Trp 
            260                 265                 270         


Leu Leu Cys Leu Arg Asp Arg Tyr Ser Phe Phe His Lys Leu Ile Pro 
        275                 280                 285             


Leu Leu Leu Ser Ser Leu Asn Asp Glu Val Pro Glu Val Arg Gln Leu 
    290                 295                 300                 


Ala Ala Ser Leu Trp Glu Asp Val Gly Leu Gln Trp Gln Lys Glu Asn 
305                 310                 315                 320 


Glu Glu Asp Leu Lys Asp Lys Leu Asp Phe Ala Pro Pro Thr Pro Pro 
                325                 330                 335     


His Tyr Pro Pro His Glu Arg Arg Pro Val Leu Gly Cys Arg Glu Leu 
            340                 345                 350         


Val Phe Arg Asn Leu Ser Lys Ile Leu Pro Ala Leu Cys His Asp Ile 
        355                 360                 365             


Thr Asp Trp Val Val Gly Thr Arg Val Lys Ser Ala Gln Leu Leu Pro 
    370                 375                 380                 


Val Leu Leu Leu His Ala Glu Asp His Ala Thr Gln His Leu Glu Val 
385                 390                 395                 400 


Val Leu Arg Thr Leu Phe Gln Ala Cys Thr Asp Glu Glu Ala Ala Val 
                405                 410                 415     


Val Gln Ser Cys Thr Arg Ser Ala Glu Leu Val Gly Thr Phe Val Ser 
            420                 425                 430         


Pro Glu Val Phe Leu Lys Leu Ile Leu Ser Thr Leu Lys Lys Thr Pro 
        435                 440                 445             


Ser Ala Ser Gly Leu Leu Val Leu Ala Ser Ala Met Arg Gly Cys Pro 
    450                 455                 460                 


Arg Glu Ala Leu Gln Pro His Leu Ala Ala Ile Ala Thr Glu Leu Ala 
465                 470                 475                 480 


Gln Ala His Ile Cys Gln Ala Ser Glu Asn Asp Leu Tyr Leu Glu Arg 
                485                 490                 495     


Leu Leu Leu Cys Val Gln Ala Leu Val Ser Val Cys His Glu Asp Cys 
            500                 505                 510         


Gly Val Ala Ser Leu Gln Leu Leu Asp Val Leu Leu Thr Ile Val Ala 
        515                 520                 525             


Leu Ala Gly Ala Thr Gly Leu Arg Asp Lys Ala Gln Glu Thr Met Asp 
    530                 535                 540                 


Ser Leu Ala Met Val Glu Gly Val Ser Ser Cys Gln Asp Leu Tyr Arg 
545                 550                 555                 560 


Lys His Ile Gly Pro Leu Leu Glu Arg Val Thr Ala Ser His Leu Asp 
                565                 570                 575     


Trp Thr Ala His Ser Pro Glu Leu Leu Gln Phe Ser Val Ile Val Ala 
            580                 585                 590         


Gln Ser Gly Pro Ala Leu Gly Glu Ala Leu Pro His Val Val Pro Thr 
        595                 600                 605             


Leu Arg Ala Cys Leu Gln Pro Ser Gln Asp Pro Gln Met Arg Leu Lys 
    610                 615                 620                 


Leu Phe Ser Ile Leu Ser Thr Val Leu Leu Arg Ala Thr Asp Thr Ile 
625                 630                 635                 640 


Asn Ser Gln Gly Gln Phe Pro Ser Tyr Leu Glu Thr Val Thr Lys Asp 
                645                 650                 655     


Ile Leu Ala Pro Asn Leu Gln Trp His Ala Gly Arg Thr Ala Ala Ala 
            660                 665                 670         


Ile Arg Thr Ala Ala Val Ser Cys Leu Trp Ala Leu Thr Ser Ser Glu 
        675                 680                 685             


Val Leu Ser Ala Glu Gln Ile Arg Asp Val Gln Glu Thr Leu Met Pro 
    690                 695                 700                 


Gln Val Leu Thr Thr Leu Glu Glu Asp Ser Lys Met Thr Arg Leu Ile 
705                 710                 715                 720 


Ser Cys Arg Ile Ile Asn Thr Phe Leu Lys Thr Ser Gly Gly Met Thr 
                725                 730                 735     


Asp Pro Glu Lys Leu Ile Arg Ile Tyr Pro Glu Leu Leu Lys Arg Leu 
            740                 745                 750         


Asp Asp Val Ser Asn Asp Val Arg Met Ala Ala Ala Ser Thr Leu Val 
        755                 760                 765             


Thr Trp Leu Gln Cys Val Lys Gly Ala Asn Ala Lys Ser Tyr Tyr Gln 
    770                 775                 780                 


Ser Ser Val Gln Tyr Leu Tyr Arg Glu Leu Leu Val His Leu Asp Asp 
785                 790                 795                 800 


Pro Glu Arg Ala Ile Gln Asp Ala Ile Leu Glu Val Leu Lys Glu Gly 
                805                 810                 815     


Ser Gly Leu Phe Pro Asp Leu Leu Val Arg Glu Thr Glu Ala Val Ile 
            820                 825                 830         


His Lys His Arg Ser Ala Thr Tyr Cys Glu Gln Leu Leu Gln His Val 
        835                 840                 845             


Gln Ala Val Pro Ala Thr Gln 
    850                 855 


<210>  3138
<211>  4516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH11__Homo_sapiens__NP_001264044

<400>  3138

Met Ala Ala Gln Val Ala Ala Arg Glu Ala Arg Asp Phe Arg Glu Ala 
1               5                   10                  15      


Pro Thr Leu Arg Leu Thr Ser Gly Ala Gly Leu Glu Ala Val Gly Ala 
            20                  25                  30          


Val Glu Leu Glu Glu Glu Glu Glu Asn Glu Glu Glu Ala Ala Ala Arg 
        35                  40                  45              


Arg Ala Arg Ser Phe Ala Gln Asp Ala Arg Val Arg Phe Leu Gly Gly 
    50                  55                  60                  


Arg Leu Ala Met Met Leu Gly Phe Thr Glu Glu Lys Trp Ser Gln Tyr 
65                  70                  75                  80  


Leu Glu Ser Glu Asp Asn Arg Gln Val Leu Gly Glu Phe Leu Glu Ser 
                85                  90                  95      


Thr Ser Pro Ala Cys Leu Val Phe Ser Phe Ala Ala Ser Gly Arg Leu 
            100                 105                 110         


Ala Ala Ser Gln Glu Ile Pro Arg Asp Ala Asn His Lys Leu Val Phe 
        115                 120                 125             


Ile Ser Lys Lys Ile Thr Glu Ser Ile Gly Val Asn Asp Phe Ser Gln 
    130                 135                 140                 


Val Val Leu Phe Gly Glu Leu Pro Ala Leu Ser Leu Gly His Val Ser 
145                 150                 155                 160 


Ala Phe Leu Asp Glu Ile Leu Val Pro Val Leu Ser Asn Lys Asn Asn 
                165                 170                 175     


His Lys Ser Trp Ser Cys Phe Thr Ser Gln Asp Met Glu Tyr His Ile 
            180                 185                 190         


Glu Val Met Lys Lys Lys Met Tyr Ile Phe Arg Gly Lys Met Ser Arg 
        195                 200                 205             


Arg Thr Leu Leu Pro Ile Pro Thr Val Ala Gly Lys Met Asp Leu Asp 
    210                 215                 220                 


Gln Asn Cys Ser Glu Asn Lys Pro Pro Ser Asn Glu Arg Ile Ile Leu 
225                 230                 235                 240 


His Ala Ile Glu Ser Val Val Ile Glu Trp Ser His Gln Ile Gln Glu 
                245                 250                 255     


Ile Ile Glu Arg Asp Ser Val Gln Arg Leu Leu Asn Gly Leu His Leu 
            260                 265                 270         


Ser Pro Gln Ala Glu Leu Asp Phe Trp Met Met Arg Arg Glu Asn Leu 
        275                 280                 285             


Ser Cys Ile Tyr Asp Gln Leu Gln Ala Pro Val Val Leu Lys Met Val 
    290                 295                 300                 


Lys Ile Leu Thr Thr Lys Gln Ser Ser Tyr Phe Pro Thr Leu Lys Asp 
305                 310                 315                 320 


Ile Phe Leu Ala Val Glu Asn Ala Leu Leu Glu Ala Gln Asp Val Glu 
                325                 330                 335     


Leu Tyr Leu Arg Pro Leu Arg Arg His Ile Gln Cys Leu Gln Glu Thr 
            340                 345                 350         


Glu Phe Pro Gln Thr Arg Ile Leu Ile Ala Pro Leu Phe His Thr Ile 
        355                 360                 365             


Cys Leu Ile Trp Ser His Ser Lys Phe Tyr Asn Thr Pro Ala Arg Val 
    370                 375                 380                 


Ile Val Leu Leu Gln Glu Phe Cys Asn Leu Phe Ile Asn Gln Ala Thr 
385                 390                 395                 400 


Ala Tyr Leu Ser Pro Glu Asp Leu Leu Arg Gly Glu Ile Glu Glu Ser 
                405                 410                 415     


Leu Glu Lys Val Gln Val Ala Val Asn Ile Leu Lys Thr Phe Lys Asn 
            420                 425                 430         


Ser Phe Phe Asn Tyr Arg Lys Lys Leu Ala Ser Tyr Phe Met Gly Arg 
        435                 440                 445             


Lys Leu Arg Pro Trp Asp Phe Gln Ser His Leu Val Phe Cys Arg Phe 
    450                 455                 460                 


Asp Lys Phe Leu Asp Arg Leu Ile Lys Ile Glu Asp Ile Phe Ala Thr 
465                 470                 475                 480 


Thr Leu Glu Phe Glu Lys Leu Glu Arg Leu Glu Phe Gly Gly Thr Lys 
                485                 490                 495     


Gly Ala Ile Leu Asn Gly Gln Val His Glu Met Ser Glu Glu Leu Met 
            500                 505                 510         


Glu Leu Cys Lys Leu Phe Lys Gln Ser Thr Tyr Asp Pro Ser Asp Cys 
        515                 520                 525             


Thr Asn Met Glu Phe Glu Ser Asp Tyr Val Ala Phe Lys Ser Lys Thr 
    530                 535                 540                 


Leu Glu Phe Asp Arg Arg Leu Gly Thr Ile Ile Cys Glu Ala Phe Phe 
545                 550                 555                 560 


Asn Cys Asn Gly Leu Glu Ala Ala Phe Lys Leu Leu Thr Ile Phe Gly 
                565                 570                 575     


Asn Phe Leu Glu Lys Pro Val Val Met Glu Ile Phe Ser Leu His Tyr 
            580                 585                 590         


Ser Thr Leu Val His Met Phe Asn Thr Glu Leu Asp Val Cys Lys Gln 
        595                 600                 605             


Leu Tyr Asn Glu His Met Lys Gln Ile Glu Cys Gly His Val Val Leu 
    610                 615                 620                 


Asn Lys Asn Met Pro Phe Thr Ser Gly Asn Met Lys Trp Ala Gln Gln 
625                 630                 635                 640 


Val Leu Gln Arg Leu Gln Met Phe Trp Ser Asn Phe Ala Ser Leu Arg 
                645                 650                 655     


Tyr Leu Phe Leu Gly Asn Pro Asp His Ala Leu Val Tyr Gln Lys Tyr 
            660                 665                 670         


Val Glu Met Thr Thr Leu Leu Asp Gln Phe Glu Ser Arg Ile Tyr Asn 
        675                 680                 685             


Glu Trp Lys Ser Asn Val Asp Glu Ile Cys Glu Phe Asn Leu Asn Gln 
    690                 695                 700                 


Pro Leu Val Lys Phe Ser Ala Ile Asn Gly Leu Leu Cys Val Asn Phe 
705                 710                 715                 720 


Asp Pro Lys Leu Val Ala Val Leu Arg Glu Val Lys Tyr Leu Leu Met 
                725                 730                 735     


Leu Lys Lys Gln Asp Ile Pro Asp Ser Ala Leu Ala Ile Phe Lys Lys 
            740                 745                 750         


Arg Asn Thr Ile Leu Lys Tyr Ile Gly Asn Leu Asp Leu Leu Val Gln 
        755                 760                 765             


Gly Tyr Asn Lys Leu Lys Gln Thr Leu Leu Glu Val Glu Tyr Pro Leu 
    770                 775                 780                 


Ile Glu Asp Glu Leu Arg Ala Ile Asp Glu Gln Leu Thr Ala Ala Thr 
785                 790                 795                 800 


Thr Trp Leu Thr Trp Gln Asp Asp Cys Trp Gly Tyr Ile Glu Arg Val 
                805                 810                 815     


Arg Ala Ala Thr Ser Glu Leu Glu His Arg Val Glu Arg Thr Gln Lys 
            820                 825                 830         


Asn Val Lys Val Ile Gln Gln Thr Met Arg Gly Trp Ala Arg Cys Val 
        835                 840                 845             


Leu Pro Pro Arg Arg Glu His Arg Arg Glu Ala Ala Phe Thr Leu Glu 
    850                 855                 860                 


Asp Lys Gly Asp Leu Phe Thr Lys Lys Tyr Lys Leu Ile Gln Gly Asp 
865                 870                 875                 880 


Gly Cys Lys Ile His Asn Leu Val Glu Glu Asn Arg Lys Leu Phe Lys 
                885                 890                 895     


Ala Asn Pro Ser Leu Asp Thr Trp Lys Ile Tyr Val Glu Phe Ile Asp 
            900                 905                 910         


Asp Ile Val Val Glu Gly Phe Phe Gln Ala Ile Met His Asp Leu Asp 
        915                 920                 925             


Phe Phe Leu Lys Asn Thr Glu Lys Gln Leu Lys Pro Ala Pro Phe Phe 
    930                 935                 940                 


Gln Ala Gln Met Ile Leu Leu Pro Pro Glu Ile Val Phe Lys Pro Ser 
945                 950                 955                 960 


Leu Asp Arg Glu Ala Gly Asp Gly Phe Tyr Asp Leu Val Glu Glu Met 
                965                 970                 975     


Leu Cys Asn Ser Phe Arg Met Ser Ala Gln Met Asn Arg Ile Ala Thr 
            980                 985                 990         


His Leu Glu Ile Lys Asn Tyr Gln  Asn Asp Met Asp Asn  Met Leu Gly 
        995                 1000                 1005             


Leu Ala  Glu Val Arg Gln Glu  Ile Met Asn Arg Val  Val Asn Val 
    1010                 1015                 1020             


Ile Asn  Lys Val Leu Asp Phe  Arg Asn Thr Leu Glu  Thr His Thr 
    1025                 1030                 1035             


Tyr Leu  Trp Val Asp Asp Arg  Ala Glu Phe Met Lys  His Phe Leu 
    1040                 1045                 1050             


Leu Tyr  Gly His Ala Val Ser  Ser Asp Glu Met Asp  Ala His Ala 
    1055                 1060                 1065             


Asn Glu  Glu Ile Pro Glu Gln  Pro Pro Thr Leu Glu  Gln Phe Lys 
    1070                 1075                 1080             


Glu Gln  Ile Asp Ile Tyr Glu  Ala Leu Tyr Val Gln  Met Ser Lys 
    1085                 1090                 1095             


Phe Glu  Asp Phe Arg Val Phe  Asp Ser Trp Phe Lys  Val Asp Met 
    1100                 1105                 1110             


Lys Pro  Phe Lys Val Ser Leu  Leu Thr Ile Ile Lys  Lys Trp Ser 
    1115                 1120                 1125             


Trp Met  Phe Gln Glu His Leu  Leu Arg Phe Val Ile  Asp Ser Leu 
    1130                 1135                 1140             


Asn Glu  Leu Gln Glu Phe Ile  Lys Glu Thr Asp Ser  Gly Leu Gln 
    1145                 1150                 1155             


Arg Glu  Leu Asn Glu Gly Asp  His Asp Gly Leu Val  Asp Ile Met 
    1160                 1165                 1170             


Val His  Leu Leu Ala Val Arg  Ser Arg Gln Arg Ala  Thr Asp Glu 
    1175                 1180                 1185             


Leu Phe  Glu Pro Leu Lys Glu  Thr Ile Thr Leu Leu  Glu Ser Tyr 
    1190                 1195                 1200             


Gly Gln  Lys Met Pro Glu Gln  Val Tyr Ile Gln Leu  Glu Glu Leu 
    1205                 1210                 1215             


Pro Glu  Arg Trp Glu Thr Thr  Lys Lys Ile Ala Ala  Thr Val Arg 
    1220                 1225                 1230             


His Glu  Val Ser Pro Leu His  Asn Ala Glu Val Thr  Leu Ile Arg 
    1235                 1240                 1245             


Lys Lys  Cys Ile Leu Phe Asp  Ala Lys Gln Ala Glu  Phe Arg Glu 
    1250                 1255                 1260             


Arg Phe  Arg His Tyr Ala Pro  Leu Gly Phe Asn Ala  Glu Asn Pro 
    1265                 1270                 1275             


Tyr Thr  Ala Leu Asp Lys Ala  Asn Glu Glu Leu Glu  Ala Leu Glu 
    1280                 1285                 1290             


Glu Glu  Met Leu Gln Met Gln  Glu Ser Thr Arg Leu  Phe Glu Val 
    1295                 1300                 1305             


Ala Leu  Pro Glu Tyr Lys Gln  Met Lys Gln Cys Arg  Lys Glu Ile 
    1310                 1315                 1320             


Lys Leu  Leu Lys Gly Leu Trp  Asp Val Ile Ile Tyr  Val Arg Arg 
    1325                 1330                 1335             


Ser Ile  Asp Asn Trp Thr Lys  Thr Gln Trp Arg Gln  Ile His Val 
    1340                 1345                 1350             


Glu Gln  Met Asp Val Glu Leu  Arg Arg Phe Ala Lys  Glu Ile Trp 
    1355                 1360                 1365             


Ser Leu  Asn Lys Glu Val Arg  Val Trp Asp Ala Tyr  Thr Gly Leu 
    1370                 1375                 1380             


Glu Gly  Thr Val Lys Asp Met  Thr Ala Ser Leu Arg  Ala Ile Thr 
    1385                 1390                 1395             


Glu Leu  Gln Ser Pro Ala Leu  Arg Asp Arg His Trp  His Gln Leu 
    1400                 1405                 1410             


Met Lys  Ala Ile Gly Val Lys  Phe Leu Ile Asn Glu  Ala Thr Thr 
    1415                 1420                 1425             


Leu Ala  Asp Leu Leu Ala Leu  Arg Leu His Arg Val  Glu Asp Asp 
    1430                 1435                 1440             


Val Arg  Arg Ile Val Asp Lys  Ala Val Lys Glu Leu  Gly Thr Glu 
    1445                 1450                 1455             


Lys Val  Ile Thr Glu Ile Ser  Gln Thr Trp Ala Thr  Met Lys Phe 
    1460                 1465                 1470             


Ser Tyr  Glu Val His Tyr Arg  Thr Gly Ile Pro Leu  Leu Lys Ser 
    1475                 1480                 1485             


Asp Glu  Gln Leu Phe Glu Thr  Leu Glu His Asn Gln  Val Gln Leu 
    1490                 1495                 1500             


Gln Thr  Leu Leu Gln Ser Lys  Tyr Val Glu Tyr Phe  Ile Glu Gln 
    1505                 1510                 1515             


Val Leu  Ser Trp Gln Asn Lys  Leu Asn Ile Ala Asp  Leu Val Ile 
    1520                 1525                 1530             


Phe Thr  Trp Met Glu Val Gln  Arg Thr Trp Ser His  Leu Glu Ser 
    1535                 1540                 1545             


Ile Phe  Val Cys Ser Glu Asp  Ile Arg Ile Gln Leu  Val Lys Asp 
    1550                 1555                 1560             


Ala Arg  Arg Phe Asp Gly Val  Asp Ala Glu Phe Lys  Glu Leu Met 
    1565                 1570                 1575             


Phe Lys  Thr Ala Lys Val Glu  Asn Val Leu Glu Ala  Thr Cys Arg 
    1580                 1585                 1590             


Pro Asn  Leu Tyr Glu Lys Leu  Lys Asp Leu Gln Ser  Arg Leu Ser 
    1595                 1600                 1605             


Leu Cys  Glu Lys Ala Leu Ala  Glu Tyr Leu Glu Thr  Lys Arg Ile 
    1610                 1615                 1620             


Ala Phe  Pro Arg Phe Tyr Phe  Val Ser Ser Ala Asp  Leu Leu Asp 
    1625                 1630                 1635             


Ile Leu  Ser Lys Gly Ala Gln  Pro Lys Gln Val Thr  Cys His Leu 
    1640                 1645                 1650             


Ala Lys  Leu Phe Asp Ser Ile  Ala Asp Leu Gln Phe  Glu Asp Asn 
    1655                 1660                 1665             


Gln Asp  Val Ser Ala His Arg  Ala Val Gly Met Tyr  Ser Lys Glu 
    1670                 1675                 1680             


Lys Glu  Tyr Val Pro Phe Gln  Ala Glu Cys Glu Cys  Val Gly His 
    1685                 1690                 1695             


Val Glu  Thr Trp Leu Leu Gln  Leu Glu Gln Thr Met  Gln Glu Thr 
    1700                 1705                 1710             


Val Arg  His Ser Ile Thr Glu  Ala Ile Val Ala Tyr  Glu Glu Lys 
    1715                 1720                 1725             


Pro Arg  Glu Leu Trp Ile Phe  Asp Phe Pro Ala Gln  Val Ala Leu 
    1730                 1735                 1740             


Thr Ser  Ser Gln Ile Trp Trp  Thr Thr Asp Val Gly  Ile Ala Phe 
    1745                 1750                 1755             


Ser Arg  Leu Glu Glu Gly Tyr  Glu Thr Ala Leu Lys  Asp Phe His 
    1760                 1765                 1770             


Lys Lys  Gln Ile Ser Gln Leu  Asn Thr Leu Ile Thr  Leu Leu Leu 
    1775                 1780                 1785             


Gly Glu  Leu Pro Pro Gly Asp  Arg Gln Lys Ile Met  Thr Ile Cys 
    1790                 1795                 1800             


Thr Ile  Asp Val His Ala Arg  Asp Val Val Ala Lys  Leu Ile Ser 
    1805                 1810                 1815             


Gln Lys  Val Val Ser Pro Gln  Ala Phe Thr Trp Leu  Ser Gln Leu 
    1820                 1825                 1830             


Arg His  Arg Trp Glu Asp Thr  Gln Lys His Cys Phe  Val Asn Ile 
    1835                 1840                 1845             


Cys Asp  Ala Gln Phe Gln Tyr  Phe Tyr Glu Tyr Leu  Gly Asn Ser 
    1850                 1855                 1860             


Pro Arg  Leu Val Ile Thr Pro  Leu Thr Asp Arg Cys  Tyr Ile Thr 
    1865                 1870                 1875             


Leu Thr  Gln Ser Leu His Leu  Thr Met Ser Gly Ala  Pro Ala Gly 
    1880                 1885                 1890             


Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Thr Lys Asp  Leu Gly Arg 
    1895                 1900                 1905             


Ala Leu  Gly Met Met Val Tyr  Val Phe Asn Cys Ser  Glu Gln Met 
    1910                 1915                 1920             


Asp Tyr  Lys Ser Ile Gly Asn  Ile Tyr Lys Gly Leu  Val Gln Thr 
    1925                 1930                 1935             


Gly Ala  Trp Gly Cys Phe Asp  Glu Phe Asn Arg Ile  Ser Val Glu 
    1940                 1945                 1950             


Val Leu  Ser Val Val Ala Val  Gln Val Lys Met Ile  His Asp Ala 
    1955                 1960                 1965             


Ile Arg  Asn Arg Lys Lys Arg  Phe Val Phe Leu Gly  Glu Ala Ile 
    1970                 1975                 1980             


Thr Leu  Lys Pro Ser Val Gly  Ile Phe Ile Thr Met  Asn Pro Gly 
    1985                 1990                 1995             


Tyr Ala  Gly Arg Thr Glu Leu  Pro Glu Asn Leu Lys  Ala Leu Phe 
    2000                 2005                 2010             


Arg Pro  Cys Ala Met Val Ala  Pro Asp Ile Glu Leu  Ile Cys Glu 
    2015                 2020                 2025             


Ile Leu  Leu Val Ala Glu Gly  Phe Val Asp Ala Arg  Ala Leu Ala 
    2030                 2035                 2040             


Arg Lys  Phe Ile Thr Leu Tyr  Thr Leu Cys Lys Glu  Leu Leu Ser 
    2045                 2050                 2055             


Lys Gln  Asp His Tyr Asp Trp  Gly Leu Arg Ala Ile  Lys Ser Val 
    2060                 2065                 2070             


Leu Val  Val Ala Gly Ser Leu  Lys Arg Gly Asp Lys  Asn Arg Pro 
    2075                 2080                 2085             


Glu Asp  Gln Val Leu Met Arg  Ala Leu Arg Asp Phe  Asn Met Pro 
    2090                 2095                 2100             


Lys Ile  Val Thr Asp Asp Ile  Pro Val Phe Leu Gly  Leu Val Gly 
    2105                 2110                 2115             


Asp Leu  Phe Pro Ala Leu Asp  Val Pro Arg Arg Arg  Lys Leu His 
    2120                 2125                 2130             


Phe Glu  Gln Met Val Arg Gln  Ser Thr Leu Glu Leu  Arg Leu Gln 
    2135                 2140                 2145             


Pro Glu  Glu Ser Phe Ile Leu  Lys Val Val Gln Leu  Glu Glu Leu 
    2150                 2155                 2160             


Leu Ala  Val Arg His Ser Val  Phe Val Val Gly Asn  Ala Gly Thr 
    2165                 2170                 2175             


Gly Lys  Ser Lys Ile Leu Arg  Thr Leu Asn Arg Thr  Tyr Val Asn 
    2180                 2185                 2190             


Met Lys  Gln Lys Pro Val Trp  Asn Asp Leu Asn Pro  Lys Ala Val 
    2195                 2200                 2205             


Thr Thr  Asp Glu Leu Phe Gly  Phe Ile His His Ala  Thr Arg Glu 
    2210                 2215                 2220             


Trp Lys  Asp Gly Lys Ile Val  Tyr Ser Tyr Phe Ile  Gly Leu Phe 
    2225                 2230                 2235             


Ser Ser  Ile Leu Arg Glu Gln  Ala Asn Leu Lys His  Asp Gly Pro 
    2240                 2245                 2250             


Lys Trp  Ile Val Leu Asp Gly  Asp Ile Asp Pro Met  Trp Ile Glu 
    2255                 2260                 2265             


Ser Leu  Asn Thr Val Met Asp  Asp Asn Lys Val Leu  Thr Leu Ala 
    2270                 2275                 2280             


Ser Asn  Glu Arg Ile Ala Leu  Thr Pro Phe Met Arg  Leu Leu Phe 
    2285                 2290                 2295             


Glu Ile  His His Leu Arg Ser  Ala Thr Pro Ala Thr  Val Ser Arg 
    2300                 2305                 2310             


Ala Gly  Ile Leu Tyr Val Asn  Pro Gln Asp Leu Gly  Trp Asn Pro 
    2315                 2320                 2325             


Tyr Val  Ala Ser Trp Ile Asp  Arg Arg Arg His Gln  Ser Glu Lys 
    2330                 2335                 2340             


Ala Asn  Leu Thr Ile Leu Phe  Asp Lys Tyr Val Pro  Ala Cys Leu 
    2345                 2350                 2355             


Asp Lys  Leu Arg Thr Ser Phe  Lys Thr Ile Thr Ser  Ile Pro Glu 
    2360                 2365                 2370             


Ser Ser  Leu Val Gln Thr Leu  Cys Val Leu Leu Glu  Cys Leu Leu 
    2375                 2380                 2385             


Thr Pro  Glu Asn Val Pro Ser  Asp Ser Pro Lys Glu  Val Tyr Glu 
    2390                 2395                 2400             


Val Tyr  Phe Val Phe Ala Cys  Ile Trp Ala Phe Gly  Gly Thr Leu 
    2405                 2410                 2415             


Leu Gln  Asp Gln Ile Ser Asp  Tyr Gln Ala Asp Phe  Ser Arg Trp 
    2420                 2425                 2430             


Trp Gln  Lys Glu Met Lys Ala  Val Lys Phe Pro Ser  Gln Gly Thr 
    2435                 2440                 2445             


Ile Phe  Asp Tyr Tyr Val Asp  His Lys Thr Lys Lys  Leu Leu Pro 
    2450                 2455                 2460             


Trp Ala  Asp Lys Ile Ala Gln  Phe Thr Met Asp Pro  Asp Val Pro 
    2465                 2470                 2475             


Leu Gln  Thr Val Leu Val His  Thr Thr Glu Thr Ala  Arg Leu Arg 
    2480                 2485                 2490             


Tyr Phe  Met Glu Leu Leu Leu  Glu Lys Gly Lys Pro  Leu Met Leu 
    2495                 2500                 2505             


Val Gly  Asn Ala Gly Val Gly  Lys Thr Val Phe Val  Gly Asp Thr 
    2510                 2515                 2520             


Leu Ala  Ser Leu Ser Glu Asp  Tyr Ile Val Ser Arg  Val Pro Phe 
    2525                 2530                 2535             


Asn Tyr  Tyr Thr Thr Ser Thr  Ala Leu Gln Lys Ile  Leu Glu Lys 
    2540                 2545                 2550             


Pro Leu  Glu Lys Lys Ala Gly  His Asn Tyr Gly Pro  Gly Gly Asn 
    2555                 2560                 2565             


Lys Lys  Leu Ile Tyr Phe Ile  Asp Asp Met Asn Met  Pro Glu Val 
    2570                 2575                 2580             


Asp Leu  Tyr Gly Thr Val Gln  Pro His Thr Leu Ile  Arg Gln His 
    2585                 2590                 2595             


Ile Asp  Tyr Gly His Trp Tyr  Asp Arg Gln Lys Val  Met Leu Lys 
    2600                 2605                 2610             


Glu Ile  His Asn Cys Gln Tyr  Val Ala Cys Met Asn  Pro Met Val 
    2615                 2620                 2625             


Gly Ser  Phe Thr Ile Asn Pro  Arg Leu Gln Arg His  Phe Thr Val 
    2630                 2635                 2640             


Phe Ala  Phe Asn Phe Pro Ser  Leu Asp Ala Leu Asn  Thr Ile Tyr 
    2645                 2650                 2655             


Gly Gln  Ile Phe Ser Phe His  Phe Gln Gln Gln Ala  Phe Ala Pro 
    2660                 2665                 2670             


Ser Ile  Leu Arg Ser Gly Pro  Thr Leu Ile Gln Ala  Thr Ile Ala 
    2675                 2680                 2685             


Phe His  Gln Thr Met Met Cys  Asn Phe Leu Pro Thr  Ala Ile Lys 
    2690                 2695                 2700             


Phe His  Tyr Ile Phe Asn Leu  Arg Asp Leu Ser Asn  Val Phe Gln 
    2705                 2710                 2715             


Gly Ile  Leu Phe Ala Ser Pro  Glu Cys Leu Lys Gly  Pro Leu Asp 
    2720                 2725                 2730             


Leu Ile  His Leu Trp Leu His  Glu Ser Ala Arg Val  Tyr Gly Asp 
    2735                 2740                 2745             


Lys Leu  Ile Asp Lys Lys Asp  Cys Asp Leu Phe Gln  Arg Arg Met 
    2750                 2755                 2760             


Leu Glu  Thr Ala Tyr Lys Tyr  Phe Glu Gly Ile Asp  Ser His Met 
    2765                 2770                 2775             


Leu Leu  Gln Gln Pro Leu Ile  Tyr Cys His Phe Ala  Asp Arg Gly 
    2780                 2785                 2790             


Lys Asp  Pro His Tyr Met Pro  Val Lys Asp Trp Glu  Val Leu Lys 
    2795                 2800                 2805             


Thr Ile  Leu Thr Glu Thr Leu  Asp Asn Tyr Asn Glu  Leu Asn Ala 
    2810                 2815                 2820             


Ala Met  His Leu Val Leu Phe  Glu Asp Ala Met Gln  His Val Cys 
    2825                 2830                 2835             


Arg Ile  Ser Arg Ile Leu Arg  Thr Pro Gln Gly Cys  Ala Leu Leu 
    2840                 2845                 2850             


Val Gly  Val Gly Gly Ser Gly  Lys Gln Ser Leu Ser  Arg Leu Ala 
    2855                 2860                 2865             


Ala Tyr  Leu Arg Gly Leu Glu  Val Phe Gln Ile Thr  Leu Thr Glu 
    2870                 2875                 2880             


Gly Tyr  Gly Ile Gln Glu Leu  Arg Val Asp Leu Ala  Asn Leu Tyr 
    2885                 2890                 2895             


Ile Arg  Thr Gly Ala Lys Asn  Met Pro Thr Val Phe  Leu Leu Thr 
    2900                 2905                 2910             


Asp Ala  Gln Val Leu Asp Glu  Ser Phe Leu Val Leu  Ile Asn Asp 
    2915                 2920                 2925             


Leu Leu  Ala Ser Gly Glu Ile  Pro Asp Leu Phe Ser  Asp Glu Asp 
    2930                 2935                 2940             


Val Asp  Lys Ile Ile Ser Gly  Ile His Asn Glu Val  His Ala Leu 
    2945                 2950                 2955             


Gly Met  Val Asp Ser Arg Glu  Asn Cys Trp Lys Phe  Phe Met Ala 
    2960                 2965                 2970             


Arg Val  Arg Leu Gln Leu Lys  Ile Ile Leu Cys Phe  Ser Pro Val 
    2975                 2980                 2985             


Gly Arg  Thr Leu Arg Val Arg  Ala Arg Lys Phe Pro  Ala Ile Val 
    2990                 2995                 3000             


Asn Cys  Thr Ala Ile Asp Trp  Phe His Ala Trp Pro  Gln Glu Ala 
    3005                 3010                 3015             


Leu Val  Ser Val Ser Arg Arg  Phe Ile Glu Glu Thr  Lys Gly Ile 
    3020                 3025                 3030             


Glu Pro  Val His Lys Asp Ser  Ile Ser Leu Phe Met  Ala His Val 
    3035                 3040                 3045             


His Thr  Thr Val Asn Glu Met  Ser Thr Arg Tyr Tyr  Gln Asn Glu 
    3050                 3055                 3060             


Arg Arg  His Asn Tyr Thr Thr  Pro Lys Ser Phe Leu  Glu Gln Ile 
    3065                 3070                 3075             


Ser Leu  Phe Lys Asn Leu Leu  Lys Lys Lys Gln Asn  Glu Val Ser 
    3080                 3085                 3090             


Glu Lys  Lys Glu Arg Leu Val  Asn Gly Ile Gln Lys  Leu Lys Thr 
    3095                 3100                 3105             


Thr Ala  Ser Gln Val Gly Asp  Leu Lys Ala Arg Leu  Ala Ser Gln 
    3110                 3115                 3120             


Glu Ala  Glu Leu Gln Leu Arg  Asn His Asp Ala Glu  Ala Leu Ile 
    3125                 3130                 3135             


Thr Lys  Ile Gly Leu Gln Thr  Glu Lys Val Ser Arg  Glu Lys Thr 
    3140                 3145                 3150             


Ile Ala  Asp Ala Glu Glu Arg  Lys Val Thr Ala Ile  Gln Thr Glu 
    3155                 3160                 3165             


Val Phe  Gln Lys Gln Arg Glu  Cys Glu Ala Asp Leu  Leu Lys Ala 
    3170                 3175                 3180             


Glu Pro  Ala Leu Val Ala Ala  Thr Ala Ala Leu Asn  Thr Leu Asn 
    3185                 3190                 3195             


Arg Val  Asn Leu Ser Glu Leu  Lys Ala Phe Pro Asn  Pro Pro Ile 
    3200                 3205                 3210             


Ala Val  Thr Asn Val Thr Ala  Ala Val Met Val Leu  Leu Ala Pro 
    3215                 3220                 3225             


Arg Gly  Arg Val Pro Lys Asp  Arg Ser Trp Lys Ala  Ala Lys Val 
    3230                 3235                 3240             


Phe Met  Gly Lys Val Asp Asp  Phe Leu Gln Ala Leu  Ile Asn Tyr 
    3245                 3250                 3255             


Asp Lys  Glu His Ile Pro Glu  Asn Cys Leu Lys Val  Val Asn Glu 
    3260                 3265                 3270             


His Tyr  Leu Lys Asp Pro Glu  Phe Asn Pro Asn Leu  Ile Arg Thr 
    3275                 3280                 3285             


Lys Ser  Phe Ala Ala Ala Gly  Leu Cys Ala Trp Val  Ile Asn Ile 
    3290                 3295                 3300             


Ile Lys  Phe Tyr Glu Val Tyr  Cys Asp Val Glu Pro  Lys Arg Gln 
    3305                 3310                 3315             


Ala Leu  Ala Gln Ala Asn Leu  Glu Leu Ala Ala Ala  Thr Glu Lys 
    3320                 3325                 3330             


Leu Glu  Ala Ile Arg Lys Lys  Leu Val Asp Leu Asp  Arg Asn Leu 
    3335                 3340                 3345             


Ser Arg  Leu Thr Ala Ser Phe  Glu Lys Ala Thr Ala  Glu Lys Val 
    3350                 3355                 3360             


Arg Cys  Gln Glu Glu Val Asn  Gln Thr Asn Lys Thr  Ile Lys Leu 
    3365                 3370                 3375             


Ala Asn  Arg Leu Val Lys Glu  Leu Glu Ala Lys Lys  Ile Arg Trp 
    3380                 3385                 3390             


Gly Gln  Ser Ile Lys Ser Phe  Glu Ala Gln Glu Lys  Thr Leu Cys 
    3395                 3400                 3405             


Gly Asp  Val Leu Leu Thr Ala  Ala Phe Val Ser Tyr  Val Gly Pro 
    3410                 3415                 3420             


Phe Thr  Arg Gln Tyr Arg Gln  Glu Leu Val His Cys  Lys Trp Val 
    3425                 3430                 3435             


Pro Phe  Leu Gln Gln Lys Val  Ser Ile Pro Leu Thr  Glu Gly Leu 
    3440                 3445                 3450             


Asp Leu  Ile Ser Met Leu Thr  Asp Asp Ala Thr Ile  Ala Ala Trp 
    3455                 3460                 3465             


Asn Asn  Glu Gly Leu Pro Ser  Asp Arg Met Ser Thr  Glu Asn Ala 
    3470                 3475                 3480             


Ala Ile  Leu Thr His Cys Glu  Arg Trp Pro Leu Val  Ile Asp Pro 
    3485                 3490                 3495             


Gln Gln  Gln Gly Ile Lys Trp  Ile Lys Asn Lys Tyr  Gly Met Asp 
    3500                 3505                 3510             


Leu Lys  Val Thr His Leu Gly  Gln Lys Gly Phe Leu  Asn Ala Ile 
    3515                 3520                 3525             


Glu Thr  Ala Leu Ala Phe Gly  Asp Val Ile Leu Ile  Glu Asn Leu 
    3530                 3535                 3540             


Glu Glu  Thr Ile Asp Pro Val  Leu Asp Pro Leu Leu  Gly Arg Asn 
    3545                 3550                 3555             


Thr Ile  Lys Lys Gly Lys Tyr  Ile Arg Ile Gly Asp  Lys Glu Cys 
    3560                 3565                 3570             


Glu Phe  Asn Lys Asn Phe Arg  Leu Ile Leu His Thr  Lys Leu Ala 
    3575                 3580                 3585             


Asn Pro  His Tyr Lys Pro Glu  Leu Gln Ala Gln Thr  Thr Leu Leu 
    3590                 3595                 3600             


Asn Phe  Thr Val Thr Glu Asp  Gly Leu Glu Ala Gln  Leu Leu Ala 
    3605                 3610                 3615             


Glu Val  Val Ser Ile Glu Arg  Pro Asp Leu Glu Lys  Leu Lys Leu 
    3620                 3625                 3630             


Val Leu  Thr Lys His Gln Asn  Asp Phe Lys Ile Glu  Leu Lys Tyr 
    3635                 3640                 3645             


Leu Glu  Asp Asp Leu Leu Leu  Arg Leu Ser Ala Ala  Glu Gly Ser 
    3650                 3655                 3660             


Phe Leu  Asp Asp Thr Lys Leu  Val Glu Arg Leu Glu  Ala Thr Lys 
    3665                 3670                 3675             


Thr Thr  Val Ala Glu Ile Glu  His Lys Val Ile Glu  Ala Lys Glu 
    3680                 3685                 3690             


Asn Glu  Arg Lys Ile Asn Glu  Ala Arg Glu Cys Tyr  Arg Pro Val 
    3695                 3700                 3705             


Ala Ala  Arg Ala Ser Leu Leu  Tyr Phe Val Ile Asn  Asp Leu Gln 
    3710                 3715                 3720             


Lys Ile  Asn Pro Leu Tyr Gln  Phe Ser Leu Lys Ala  Phe Asn Val 
    3725                 3730                 3735             


Leu Phe  His Arg Ala Ile Glu  Gln Ala Asp Lys Val  Glu Asp Met 
    3740                 3745                 3750             


Gln Gly  Arg Ile Ser Ile Leu  Met Glu Ser Ile Thr  His Ala Val 
    3755                 3760                 3765             


Phe Leu  Tyr Thr Ser Gln Ala  Leu Phe Glu Lys Asp  Lys Leu Thr 
    3770                 3775                 3780             


Phe Leu  Ser Gln Met Ala Phe  Gln Ile Leu Leu Arg  Lys Lys Glu 
    3785                 3790                 3795             


Ile Asp  Pro Leu Glu Leu Asp  Phe Leu Leu Arg Phe  Thr Val Glu 
    3800                 3805                 3810             


His Thr  His Leu Ser Pro Val  Asp Phe Leu Thr Ser  Gln Ser Trp 
    3815                 3820                 3825             


Ser Ala  Ile Lys Ala Ile Ala  Val Met Glu Glu Phe  Arg Gly Ile 
    3830                 3835                 3840             


Asp Arg  Asp Val Glu Gly Ser  Ala Lys Gln Trp Arg  Lys Trp Val 
    3845                 3850                 3855             


Glu Ser  Glu Cys Pro Glu Lys  Glu Lys Leu Pro Gln  Glu Trp Lys 
    3860                 3865                 3870             


Lys Lys  Ser Leu Ile Gln Lys  Leu Ile Leu Leu Arg  Ala Met Arg 
    3875                 3880                 3885             


Pro Asp  Arg Met Thr Tyr Ala  Leu Arg Asn Phe Val  Glu Glu Lys 
    3890                 3895                 3900             


Leu Gly  Ala Lys Tyr Val Glu  Arg Thr Arg Leu Asp  Leu Val Lys 
    3905                 3910                 3915             


Ala Phe  Glu Glu Ser Ser Pro  Ala Thr Pro Ile Phe  Phe Ile Leu 
    3920                 3925                 3930             


Ser Pro  Gly Val Asp Ala Leu  Lys Asp Leu Glu Ile  Leu Gly Lys 
    3935                 3940                 3945             


Arg Leu  Gly Phe Thr Ile Asp  Ser Gly Lys Phe His  Asn Val Ser 
    3950                 3955                 3960             


Leu Gly  Gln Gly Gln Glu Thr  Val Ala Glu Val Ala  Leu Glu Lys 
    3965                 3970                 3975             


Ala Ser  Lys Gly Gly His Trp  Val Ile Leu Gln Asn  Val His Leu 
    3980                 3985                 3990             


Val Ala  Lys Trp Leu Gly Thr  Leu Glu Lys Leu Leu  Glu Arg Phe 
    3995                 4000                 4005             


Ser Gln  Gly Ser His Arg Asp  Tyr Arg Val Phe Met  Ser Ala Glu 
    4010                 4015                 4020             


Ser Ala  Pro Thr Pro Asp Glu  His Ile Ile Pro Gln  Gly Leu Leu 
    4025                 4030                 4035             


Glu Asn  Ser Ile Lys Ile Thr  Asn Glu Pro Pro Thr  Gly Met Leu 
    4040                 4045                 4050             


Ala Asn  Leu His Ala Ala Leu  Tyr Asn Phe Asp Gln  Asp Thr Leu 
    4055                 4060                 4065             


Glu Ile  Cys Ser Lys Glu Gln  Glu Phe Lys Ser Ile  Leu Phe Ser 
    4070                 4075                 4080             


Leu Cys  Tyr Phe His Ala Cys  Val Ala Gly Arg Leu  Arg Phe Gly 
    4085                 4090                 4095             


Pro Gln  Gly Trp Ser Arg Ser  Tyr Pro Phe Asn Pro  Gly Asp Leu 
    4100                 4105                 4110             


Thr Ile  Cys Ala Ser Val Leu  Tyr Asn Tyr Leu Glu  Ala Asn Ser 
    4115                 4120                 4125             


Lys Val  Pro Trp Glu Asp Leu  Arg Tyr Leu Phe Gly  Glu Ile Met 
    4130                 4135                 4140             


Tyr Gly  Gly His Ile Thr Asp  Asp Trp Asp Arg Lys  Leu Cys Arg 
    4145                 4150                 4155             


Val Tyr  Leu Glu Glu Phe Met  Asn Pro Ser Leu Thr  Glu Asp Glu 
    4160                 4165                 4170             


Leu Met  Leu Ala Pro Gly Phe  Ala Ala Pro Pro Tyr  Leu Asp Tyr 
    4175                 4180                 4185             


Ala Gly  Tyr His Gln Tyr Ile  Glu Glu Met Leu Pro  Pro Glu Ser 
    4190                 4195                 4200             


Pro Ala  Leu Tyr Gly Leu His  Pro Asn Ala Glu Ile  Glu Phe Leu 
    4205                 4210                 4215             


Thr Val  Thr Ser Asn Thr Leu  Phe Arg Thr Leu Leu  Glu Met Gln 
    4220                 4225                 4230             


Pro Arg  Asn Ala Leu Ser Gly  Asp Glu Leu Gly Gln  Ser Thr Glu 
    4235                 4240                 4245             


Glu Lys  Val Lys Asn Val Leu  Asp Asp Ile Leu Glu  Lys Leu Pro 
    4250                 4255                 4260             


Glu Glu  Phe Asn Met Ala Glu  Ile Met Gln Lys Asn  Ser Asn Arg 
    4265                 4270                 4275             


Ser Pro  Tyr Val Leu Val Cys  Phe Gln Glu Cys Glu  Arg Met Asn 
    4280                 4285                 4290             


Ile Leu  Ile Arg Glu Ile Arg  Ile Ser Leu Glu Gln  Leu Asp Leu 
    4295                 4300                 4305             


Ser Leu  Lys Gly Glu Leu Ala  Leu Ser Pro Ala Val  Glu Ala Gln 
    4310                 4315                 4320             


Gln Phe  Ala Leu Ser Tyr Asp  Thr Val Pro Asp Thr  Trp Ser Lys 
    4325                 4330                 4335             


Leu Ala  Tyr Pro Ser Thr Tyr  Gly Leu Ala Gln Trp  Phe Asn Asp 
    4340                 4345                 4350             


Leu Leu  Leu Arg Cys Arg Glu  Leu Asp Thr Trp Thr  Gln Asp Leu 
    4355                 4360                 4365             


Thr Leu  Pro Ala Val Val Trp  Leu Ser Gly Phe Phe  Asn Pro Gln 
    4370                 4375                 4380             


Ser Phe  Leu Thr Ala Ile Met  Gln Thr Met Ala Arg  Lys Asn Glu 
    4385                 4390                 4395             


Trp Pro  Leu Asp Lys Thr Arg  Leu Thr Ala Asp Val  Thr Lys Lys 
    4400                 4405                 4410             


Thr Lys  Glu Asp Tyr Gly His  Pro Pro Arg Glu Gly  Ala Tyr Leu 
    4415                 4420                 4425             


His Gly  Leu Phe Met Glu Gly  Ala Arg Trp Asp Thr  Gln Ala Gly 
    4430                 4435                 4440             


Thr Ile  Val Glu Ala Arg Leu  Lys Glu Leu Ala Cys  Pro Met Pro 
    4445                 4450                 4455             


Val Ile  Phe Ala Lys Ala Thr  Pro Val Asp Arg Gln  Glu Thr Lys 
    4460                 4465                 4470             


Gln Thr  Tyr Glu Cys Pro Val  Tyr Arg Thr Lys Leu  Arg Gly Pro 
    4475                 4480                 4485             


Ser Tyr  Ile Trp Thr Phe Arg  Leu Lys Ser Glu Glu  Lys Thr Ala 
    4490                 4495                 4500             


Lys Trp  Val Leu Ala Gly Val  Ala Leu Leu Leu Glu  Ala 
    4505                 4510                 4515     


<210>  3139
<211>  3964
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH12__Homo_sapiens__NP_001278590

<400>  3139

Met Ser Asp Ala Asn Lys Ala Ala Ile Ala Ala Glu Lys Glu Ala Leu 
1               5                   10                  15      


Asn Leu Lys Leu Pro Pro Ile Val His Leu Pro Glu Asn Ile Gly Val 
            20                  25                  30          


Asp Thr Pro Thr Gln Ser Lys Leu Leu Lys Tyr Arg Arg Ser Lys Glu 
        35                  40                  45              


Gln Gln Gln Lys Ile Asn Gln Leu Val Ile Asp Gly Ala Lys Arg Asn 
    50                  55                  60                  


Leu Asp Arg Thr Leu Gly Lys Arg Thr Pro Leu Leu Pro Pro Pro Asp 
65                  70                  75                  80  


Tyr Pro Gln Thr Met Thr Ser Glu Met Lys Lys Lys Gly Phe Asn Tyr 
                85                  90                  95      


Ile Tyr Met Lys Gln Cys Val Glu Ser Ser Pro Leu Val Pro Ile Gln 
            100                 105                 110         


Gln Glu Trp Leu Asp His Met Leu Arg Leu Ile Pro Glu Ser Leu Lys 
        115                 120                 125             


Glu Gly Lys Glu Arg Glu Glu Leu Leu Glu Ser Leu Ile Asn Glu Val 
    130                 135                 140                 


Ser Ser Asp Phe Glu Asn Ser Met Lys Arg Tyr Leu Val Gln Ser Val 
145                 150                 155                 160 


Leu Val Lys Pro Pro Val Lys Ser Leu Glu Asp Glu Gly Gly Pro Leu 
                165                 170                 175     


Pro Glu Ser Pro Val Gly Leu Asp Tyr Ser Asn Pro Trp His Ser Ser 
            180                 185                 190         


Tyr Val Gln Ala Arg Asn Gln Ile Phe Ser Asn Leu His Ile Ile His 
        195                 200                 205             


Pro Thr Met Lys Met Leu Leu Asp Leu Gly Tyr Thr Thr Phe Ala Asp 
    210                 215                 220                 


Thr Val Leu Leu Asp Phe Thr Gly Ile Arg Ala Lys Gly Pro Ile Asp 
225                 230                 235                 240 


Cys Glu Ser Leu Lys Thr Asp Leu Ser Ile Gln Thr Arg Asn Ala Glu 
                245                 250                 255     


Glu Lys Ile Met Asn Thr Trp Tyr Pro Lys Val Ile Asn Leu Phe Thr 
            260                 265                 270         


Lys Lys Glu Ala Leu Glu Gly Val Lys Pro Glu Lys Leu Asp Ala Phe 
        275                 280                 285             


Tyr Ser Cys Val Ser Thr Leu Met Ser Asn Gln Leu Lys Asp Leu Leu 
    290                 295                 300                 


Arg Arg Thr Val Glu Gly Phe Val Lys Leu Phe Asp Pro Lys Asp Gln 
305                 310                 315                 320 


Gln Arg Leu Pro Ile Phe Lys Ile Glu Leu Thr Phe Asp Asp Asp Lys 
                325                 330                 335     


Met Glu Phe Tyr Pro Thr Phe Gln Asp Leu Glu Asp Asn Val Leu Ser 
            340                 345                 350         


Leu Val Glu Arg Ile Ala Glu Ala Leu Gln Asn Val Gln Thr Ile Pro 
        355                 360                 365             


Ser Trp Leu Ser Gly Thr Ser Thr Pro Val Asn Leu Asp Thr Glu Leu 
    370                 375                 380                 


Pro Glu His Val Leu His Trp Ala Val Asp Thr Leu Lys Ala Ala Val 
385                 390                 395                 400 


His Arg Asn Leu Glu Gly Ala Arg Lys His Tyr Glu Thr Tyr Val Glu 
                405                 410                 415     


Lys Tyr Asn Trp Leu Leu Asp Gly Thr Ala Val Glu Asn Ile Glu Thr 
            420                 425                 430         


Phe Gln Thr Glu Asp His Thr Phe Asp Glu Tyr Thr Glu Phe Ile Glu 
        435                 440                 445             


Lys Phe Leu Ser Leu Ala Ser Glu Ile Met Leu Leu Pro Gln Trp Ile 
    450                 455                 460                 


His Tyr Thr Met Val Arg Leu Asp Cys Glu Asp Leu Lys Thr Gly Leu 
465                 470                 475                 480 


Thr Asn Lys Ala Lys Ala Phe Ala Asn Ile Leu Leu Asn Asp Ile Ala 
                485                 490                 495     


Ser Lys Tyr Arg Lys Glu Asn Glu Cys Ile Cys Ser Glu Phe Glu Ala 
            500                 505                 510         


Ile Lys Glu His Ala Leu Lys Val Pro Glu Thr Thr Glu Glu Met Met 
        515                 520                 525             


Asp Leu Ile Ser Tyr Val Glu Lys Ala Arg Thr Val Gly Ile Glu Glu 
    530                 535                 540                 


Leu Ile Leu Arg Ile Gln Glu Ser Lys Arg Gln Met Ser Tyr Phe Leu 
545                 550                 555                 560 


Asp Val Phe Leu Phe Pro Gln Glu Asp Leu Ala Leu Asn Ala Thr Val 
                565                 570                 575     


Leu Met Trp Pro Arg Lys Ile Asn Pro Ile Phe Asp Glu Asn Asp Glu 
            580                 585                 590         


Leu Ile Glu Asn Ala Lys His Lys Lys Glu Asn Glu Leu Met Ala Lys 
        595                 600                 605             


Arg Glu Lys Leu Ile Leu Glu Ile Glu Lys Glu Ser Arg Arg Met Glu 
    610                 615                 620                 


Glu Phe Thr Glu Phe Ala Glu Leu Glu Arg Met Gln Gln Tyr Val Thr 
625                 630                 635                 640 


Asp Val Arg Gln Leu Gln Lys Arg Ile Gln Glu Ser Glu Glu Ala Val 
                645                 650                 655     


Gln Phe Ile Asn Lys Glu Glu Glu Leu Phe Lys Trp Glu Leu Thr Lys 
            660                 665                 670         


Tyr Pro Glu Leu Asp Lys Leu Lys Val Asn Ile Glu Pro Tyr Gln Lys 
        675                 680                 685             


Phe Phe Asn Phe Val Leu Lys Trp Gln Arg Ser Glu Lys Arg Trp Met 
    690                 695                 700                 


Asp Gly Gly Phe Leu Asp Leu Asn Gly Glu Ser Met Glu Ala Asp Val 
705                 710                 715                 720 


Glu Glu Phe Ser Arg Glu Ile Phe Lys Thr Leu Lys Phe Phe Gln Thr 
                725                 730                 735     


Lys Leu Lys Lys Glu Leu Gln Glu Lys Arg Lys Ala Ala Arg Lys Arg 
            740                 745                 750         


Ser Leu Glu Glu Glu Lys Ile Glu Glu Glu Pro Lys Asp Asn Ala Thr 
        755                 760                 765             


Ile Thr Met Cys Ser Thr Val Met Glu Gln Ile Lys Ala Phe Lys Glu 
    770                 775                 780                 


Tyr Ile Pro Thr Val Ser Ile Leu Cys Asn Pro Gly Met Arg Ala Arg 
785                 790                 795                 800 


His Trp Lys Gln Ile Ser Glu Ile Val Gly Tyr Asp Leu Thr Pro Asp 
                805                 810                 815     


Ser Gly Thr Thr Leu Arg Lys Val Leu Lys Leu Asn Leu Thr Pro Tyr 
            820                 825                 830         


Leu Glu Gln Phe Glu Val Ile Ser Ala Gly Ala Ser Lys Glu Phe Ser 
        835                 840                 845             


Leu Glu Lys Ala Met Asn Thr Met Ile Gly Thr Trp Glu Asp Ile Ala 
    850                 855                 860                 


Phe His Ile Ser Leu Tyr Arg Asp Thr Gly Val Cys Ile Leu Ser Ser 
865                 870                 875                 880 


Val Asp Glu Ile Gln Ala Ile Leu Asp Asp Gln Ile Ile Lys Thr Gln 
                885                 890                 895     


Thr Met Arg Gly Ser Pro Phe Ile Lys Pro Phe Glu His Glu Ile Lys 
            900                 905                 910         


Ala Trp Glu Asp Arg Leu Ile Arg Ile Gln Glu Thr Ile Asp Glu Trp 
        915                 920                 925             


Leu Lys Val Gln Ala Gln Trp Leu Tyr Leu Glu Pro Ile Phe Cys Ser 
    930                 935                 940                 


Glu Asp Ile Met Gln Gln Met Pro Glu Glu Gly Arg Gln Phe Gln Thr 
945                 950                 955                 960 


Val Asp Arg His Trp Arg Asp Ile Met Lys Phe Cys Ala Lys Asp Pro 
                965                 970                 975     


Lys Val Leu Ala Ala Thr Ser Leu Thr Gly Leu Leu Glu Lys Leu Gln 
            980                 985                 990         


Asn Cys Asn Glu Leu Leu Glu Lys  Ile Met Lys Gly Leu  Asn Ala Tyr 
        995                 1000                 1005             


Leu Glu  Lys Lys Arg Leu Phe  Phe Pro Arg Phe Phe  Phe Leu Ser 
    1010                 1015                 1020             


Asn Asp  Glu Met Leu Glu Ile  Leu Ser Glu Thr Lys  Asp Pro Leu 
    1025                 1030                 1035             


Arg Val  Gln Pro His Leu Lys  Lys Cys Phe Glu Gly  Ile Ala Lys 
    1040                 1045                 1050             


Leu Glu  Phe Leu Pro Asn Leu  Asp Ile Lys Ala Met  Tyr Ser Ser 
    1055                 1060                 1065             


Glu Gly  Glu Arg Val Glu Leu  Ile Ala Leu Ile Ser  Thr Ser Ala 
    1070                 1075                 1080             


Ala Arg  Gly Ala Val Glu Lys  Trp Leu Ile Gln Val  Glu Asp Leu 
    1085                 1090                 1095             


Met Leu  Arg Ser Val His Asp  Val Ile Ala Ala Ala  Arg Leu Ala 
    1100                 1105                 1110             


Tyr Pro  Glu Ser Ala Arg Arg  Asp Trp Val Arg Glu  Trp Pro Gly 
    1115                 1120                 1125             


Gln Val  Val Leu Cys Ile Ser  Gln Met Phe Trp Thr  Ser Glu Thr 
    1130                 1135                 1140             


Gln Glu  Val Ile Ser Gly Gly  Thr Glu Gly Leu Lys  Lys Tyr Tyr 
    1145                 1150                 1155             


Lys Glu  Leu Gln Asn Gln Leu  Asn Glu Ile Val Glu  Leu Val Arg 
    1160                 1165                 1170             


Gly Lys  Leu Ser Lys Gln Thr  Arg Thr Thr Leu Gly  Ala Leu Val 
    1175                 1180                 1185             


Thr Ile  Asp Val His Ala Arg  Asp Val Val Met Asp  Met Ile Lys 
    1190                 1195                 1200             


Met Gly  Val Ser His Asp Thr  Asp Phe Leu Trp Leu  Ala Gln Leu 
    1205                 1210                 1215             


Arg Tyr  Tyr Trp Glu Asn Glu  Asn Ala Arg Val Arg  Ile Ile Asn 
    1220                 1225                 1230             


Cys Asn  Val Lys Tyr Ala Tyr  Glu Tyr Leu Gly Asn  Ser Pro Arg 
    1235                 1240                 1245             


Leu Val  Ile Thr Pro Leu Thr  Asp Arg Cys Tyr Arg  Thr Leu Ile 
    1250                 1255                 1260             


Gly Ala  Phe Tyr Leu Asn Leu  Gly Gly Ala Pro Glu  Gly Pro Ala 
    1265                 1270                 1275             


Gly Thr  Gly Lys Thr Glu Thr  Thr Lys Asp Leu Ala  Lys Ala Leu 
    1280                 1285                 1290             


Ala Val  Gln Cys Val Val Phe  Asn Cys Ser Asp Gly  Leu Asp Tyr 
    1295                 1300                 1305             


Leu Ala  Met Gly Lys Phe Phe  Lys Gly Leu Ala Ser  Ser Gly Ala 
    1310                 1315                 1320             


Trp Ala  Cys Phe Asp Glu Phe  Asn Arg Ile Glu Leu  Glu Val Leu 
    1325                 1330                 1335             


Ser Val  Val Ala Gln Gln Ile  Leu Cys Ile Gln Arg  Ala Ile Gln 
    1340                 1345                 1350             


Gln Lys  Leu Val Val Phe Val  Phe Glu Gly Thr Glu  Leu Lys Leu 
    1355                 1360                 1365             


Asn Pro  Asn Cys Phe Val Ala  Ile Thr Met Asn Pro  Gly Tyr Ala 
    1370                 1375                 1380             


Gly Arg  Ser Glu Leu Pro Asp  Asn Leu Lys Val Leu  Phe Arg Thr 
    1385                 1390                 1395             


Val Ala  Met Met Val Pro Asn  Tyr Ala Leu Ile Ala  Glu Ile Ser 
    1400                 1405                 1410             


Leu Tyr  Ser Tyr Gly Phe Leu  Asn Ala Arg Pro Leu  Ser Val Lys 
    1415                 1420                 1425             


Ile Val  Met Thr Tyr Arg Leu  Cys Ser Glu Gln Leu  Ser Ser Gln 
    1430                 1435                 1440             


Phe His  Tyr Asp Tyr Gly Met  Arg Ala Val Lys Ala  Val Leu Val 
    1445                 1450                 1455             


Ala Ala  Gly Asn Leu Lys Leu  Lys Tyr Pro Asn Glu  Asn Glu Asp 
    1460                 1465                 1470             


Ile Leu  Leu Leu Arg Ser Ile  Lys Asp Val Asn Glu  Pro Lys Phe 
    1475                 1480                 1485             


Leu Ser  His Asp Ile Pro Leu  Phe Asn Gly Ile Thr  Ser Asp Leu 
    1490                 1495                 1500             


Phe Pro  Gly Ile Lys Leu Pro  Glu Ala Asp Tyr His  Glu Phe Leu 
    1505                 1510                 1515             


Glu Cys  Ala His Glu Ala Cys  Asn Val His Asn Leu  Gln Pro Val 
    1520                 1525                 1530             


Lys Phe  Phe Leu Glu Lys Ile  Ile Gln Thr Tyr Glu  Met Met Ile 
    1535                 1540                 1545             


Val Arg  His Gly Phe Met Leu  Val Gly Glu Pro Phe  Ala Ala Lys 
    1550                 1555                 1560             


Thr Lys  Val Leu His Val Leu  Ala Asp Thr Leu Thr  Leu Met Asn 
    1565                 1570                 1575             


Glu His  Gly Tyr Gly Glu Glu  Glu Lys Val Ile Tyr  Arg Thr Val 
    1580                 1585                 1590             


Asn Pro  Lys Ser Ile Thr Met  Gly Gln Leu Phe Gly  Gln Phe Asp 
    1595                 1600                 1605             


Pro Val  Ser His Glu Trp Thr  Asp Gly Ile Val Ala  Asn Thr Phe 
    1610                 1615                 1620             


Arg Glu  Phe Ala Leu Ser Glu  Thr Pro Asp Arg Lys  Trp Val Val 
    1625                 1630                 1635             


Phe Asp  Gly Pro Ile Asp Thr  Leu Trp Ile Glu Ser  Met Asn Thr 
    1640                 1645                 1650             


Val Leu  Asp Asp Asn Lys Lys  Leu Cys Leu Met Ser  Gly Glu Ile 
    1655                 1660                 1665             


Ile Gln  Met Ser Pro Gln Met  Ser Leu Ile Phe Glu  Thr Met Asp 
    1670                 1675                 1680             


Leu Ser  Gln Ala Ser Pro Ala  Thr Val Ser Arg Cys  Gly Met Ile 
    1685                 1690                 1695             


Tyr Leu  Glu Pro Ser Gln Leu  Gly Trp Glu Pro Leu  Val Ser Ser 
    1700                 1705                 1710             


Trp Leu  Asn Ser Leu Lys Gly  Pro Leu Cys Glu Pro  Glu Tyr Gln 
    1715                 1720                 1725             


Ala Leu  Leu Arg Gly Leu Phe  Ala Trp Leu Ile Pro  Pro Ser Leu 
    1730                 1735                 1740             


Asn Gln  Arg Val Glu Leu Phe  Gln Leu Asn Tyr Leu  Tyr Thr Thr 
    1745                 1750                 1755             


Ile Val  Ser Lys Ile Leu Lys  Ile Leu Ile Thr Phe  Arg Ile Ser 
    1760                 1765                 1770             


Asn Tyr  Phe Lys Tyr Val Pro  Leu Lys Thr Gln Cys  Thr Phe Ile 
    1775                 1780                 1785             


Lys Phe  Phe Leu His Gln Gln  Ala Cys Phe Ile Phe  Ser Leu Ile 
    1790                 1795                 1800             


Trp Ser  Ile Gly Gly Ser Cys  Asp Thr Asp Gly Arg  Arg Val Phe 
    1805                 1810                 1815             


Asp Thr  Phe Ile Arg Leu Ile  Ile Leu Gly Lys Asp  Asp Glu Asn 
    1820                 1825                 1830             


Pro Val  Pro Asp Ser Val Gly  Lys Trp Glu Cys Pro  Phe Asp Glu 
    1835                 1840                 1845             


Lys Gly  Leu Val Tyr Asp Tyr  Met Tyr Glu Leu Lys  Asn Lys Gly 
    1850                 1855                 1860             


Arg Trp  Val His Trp Asn Glu  Leu Ile Lys Asn Thr  Asn Leu Gly 
    1865                 1870                 1875             


Asp Lys  Gln Ile Lys Ile Gln  Asp Ile Ile Val Pro  Thr Met Asp 
    1880                 1885                 1890             


Thr Ile  Arg Tyr Thr Phe Leu  Met Asp Leu Ser Ile  Thr Tyr Ala 
    1895                 1900                 1905             


Lys Pro  Leu Leu Phe Val Gly  Pro Thr Gly Thr Gly  Lys Ser Val 
    1910                 1915                 1920             


Tyr Val  Lys Asp Lys Leu Met  Asn His Leu Glu Lys  Asp Gln Tyr 
    1925                 1930                 1935             


Phe Pro  Phe Tyr Ile Asn Leu  Ser Ala Arg Thr Ser  Ala Asn Gln 
    1940                 1945                 1950             


Val Gln  Asn Ile Ile Met Ala  Arg Leu Asp Lys Arg  Arg Lys Gly 
    1955                 1960                 1965             


Val Phe  Gly Pro Pro Met Gly  Lys Lys Cys Ile Ile  Phe Ile Asp 
    1970                 1975                 1980             


Asp Met  Asn Met Pro Ala Leu  Glu Lys Tyr Gly Ala  Gln Pro Pro 
    1985                 1990                 1995             


Ile Glu  Leu Leu Arg Gln Phe  Phe Asp Cys Gly His  Trp Tyr Asp 
    2000                 2005                 2010             


Leu Lys  Asp Thr Ser Lys Ile  Thr Leu Val Asp Ile  Glu Leu Ile 
    2015                 2020                 2025             


Ala Ala  Met Gly Pro Pro Gly  Gly Gly Arg Asn Pro  Val Thr Pro 
    2030                 2035                 2040             


Arg Cys  Ile Arg His Phe Asn  Ile Cys Ser Ile Asn  Ser Phe Ser 
    2045                 2050                 2055             


Asp Glu  Thr Met Val Arg Ile  Phe Ser Ser Ile Val  Ala Phe Tyr 
    2060                 2065                 2070             


Leu Arg  Thr His Glu Phe Pro  Pro Glu Tyr Phe Val  Ile Gly Asn 
    2075                 2080                 2085             


Gln Ile  Val Asn Gly Thr Met  Glu Ile Tyr Lys Gln  Ser Val Glu 
    2090                 2095                 2100             


Asn Leu  Leu Pro Thr Pro Thr  Lys Ser His Tyr Thr  Phe Asn Leu 
    2105                 2110                 2115             


Arg Asp  Phe Ser Arg Val Ile  Arg Gly Cys Leu Leu  Ile Glu Arg 
    2120                 2125                 2130             


Asp Ala  Val Ala Asn Lys His  Thr Met Ile Arg Leu  Phe Val His 
    2135                 2140                 2145             


Glu Val  Leu Arg Val Phe Tyr  Asp Arg Leu Ile Asn  Asp Asp Asp 
    2150                 2155                 2160             


Arg Arg  Trp Leu Phe Gln Leu  Thr Lys Thr Val Ile  Lys Asp His 
    2165                 2170                 2175             


Phe Lys  Glu Ser Phe His Ser  Ile Phe Ser His Leu  Arg Lys Gln 
    2180                 2185                 2190             


Asn Ala  Pro Val Thr Glu Glu  Asp Leu Arg Asn Leu  Met Phe Gly 
    2195                 2200                 2205             


Asp Tyr  Met Asn Pro Asp Leu  Glu Gly Asp Asp Arg  Val Tyr Ile 
    2210                 2215                 2220             


Glu Ile  Pro Asn Ile His His  Phe Ser Asp Val Val  Asp Gln Cys 
    2225                 2230                 2235             


Leu Asp  Glu Tyr Asn Gln Thr  His Lys Thr Arg Met  Asn Leu Val 
    2240                 2245                 2250             


Ile Phe  Arg Tyr Val Leu Glu  His Leu Ser Arg Ile  Cys Arg Val 
    2255                 2260                 2265             


Leu Lys  Gln Ser Gly Gly Asn  Ala Leu Leu Val Gly  Leu Gly Gly 
    2270                 2275                 2280             


Ser Gly  Arg Gln Ser Leu Thr  Arg Leu Ala Thr Ser  Met Ala Lys 
    2285                 2290                 2295             


Met His  Ile Phe Gln Pro Glu  Ile Ser Lys Ser Tyr  Gly Met Asn 
    2300                 2305                 2310             


Glu Trp  Arg Glu Asp Met Lys  Gly Leu Leu Arg Asn  Val Gly Met 
    2315                 2320                 2325             


Lys Gly  Gln Lys Thr Val Phe  Leu Ile Thr Asp Thr  Gln Ile Lys 
    2330                 2335                 2340             


Glu Glu  Ala Phe Leu Glu Asp  Ile Asp Ser Val Leu  Asn Thr Gly 
    2345                 2350                 2355             


Glu Val  Pro Asn Ile Phe Ala  Ala Asp Glu Lys Gln  Glu Val Met 
    2360                 2365                 2370             


Glu Gly  Val Arg Pro Val Ala  Gln Ala Gly Asn Lys  His Asp Glu 
    2375                 2380                 2385             


Leu Ser  Pro Leu Ala Leu Phe  Ala Phe Phe Val Asn  Arg Cys Lys 
    2390                 2395                 2400             


Asp Asn  Leu His Val Val Val  Ala Phe Ser Pro Ile  Gly Asp Ala 
    2405                 2410                 2415             


Phe Arg  Asn Arg Leu Arg Gln  Phe Pro Ser Leu Ile  Asn Cys Cys 
    2420                 2425                 2430             


Thr Ile  Asp Trp Phe Gln Ser  Trp Pro Glu Asp Ala  Leu Glu Arg 
    2435                 2440                 2445             


Val Ala  Val Lys Phe Leu Glu  Thr Leu Glu Leu Thr  Glu Val Glu 
    2450                 2455                 2460             


Gln Gln  Glu Ile Val Pro Ile  Cys Lys His Phe His  Thr Ser Ile 
    2465                 2470                 2475             


Met Asp  Leu Ser Glu Arg Phe  Leu His Glu Leu Gly  Arg His Asn 
    2480                 2485                 2490             


Tyr Val  Thr Ala Thr Ser Tyr  Leu Glu Leu Ile Gly  Ser Phe Arg 
    2495                 2500                 2505             


Gln Leu  Leu Thr Gln Lys Arg  Gln Ala Val Met Glu  Ala Lys Gln 
    2510                 2515                 2520             


Arg Tyr  Met Asn Gly Leu Asp  Lys Leu Ala Phe Ala  Glu Ser Gln 
    2525                 2530                 2535             


Val Gly  Glu Met Gln Met Glu  Leu Val Glu Leu Gln  Pro Lys Leu 
    2540                 2545                 2550             


Glu Glu  Ala Lys Ile Glu Asn  Ala Asn Met Met Gln  Val Ile Glu 
    2555                 2560                 2565             


Ile Glu  Ser Val Gln Val Glu  Ala Lys Arg Gln Phe  Val Lys Leu 
    2570                 2575                 2580             


Asp Glu  Glu Ile Ala Ser Gly  Lys Ala Glu Glu Ala  Gln Ala Leu 
    2585                 2590                 2595             


Lys Asn  Glu Cys Glu Ser Asp  Leu Ala Glu Ala Ile  Pro Ala Leu 
    2600                 2605                 2610             


Glu Ala  Ala Leu Ser Ala Leu  Asp Thr Leu Lys Pro  Ala Asp Ile 
    2615                 2620                 2625             


Thr Ile  Val Lys Ser Met Lys  Asn Pro Pro Ser Gly  Val Lys Leu 
    2630                 2635                 2640             


Val Met  Ala Ala Val Cys Val  Met Lys Asp Ile Lys  Pro Glu Lys 
    2645                 2650                 2655             


Ile Ser  Asp Pro Ser Gly Thr  Gly Gly Lys Ile Leu  Asp Tyr Trp 
    2660                 2665                 2670             


Gly Pro  Ser Lys Lys Leu Leu  Gly Asp Met Asn Phe  Leu Arg Asp 
    2675                 2680                 2685             


Leu Lys  Glu Tyr Asp Lys Asp  Asn Ile Pro Val Thr  Val Met Gln 
    2690                 2695                 2700             


Lys Ile  Arg Ser Glu Tyr Leu  Met Asn Pro Glu Phe  Asp Pro Pro 
    2705                 2710                 2715             


Lys Val  Ala Lys Ala Ser Ser  Ala Ala Glu Gly Leu  Cys Lys Trp 
    2720                 2725                 2730             


Ile Met  Ala Met Glu Val Tyr  Asp Arg Val Ala Lys  Val Val Ala 
    2735                 2740                 2745             


Pro Lys  Lys Ala Arg Leu Ser  Glu Ala Gln Lys Ser  Leu Ala Glu 
    2750                 2755                 2760             


Thr Met  Glu Leu Leu Asn Gln  Lys Arg Ala Glu Leu  Ala Glu Val 
    2765                 2770                 2775             


Glu His  His Leu Glu Asn Leu  Gln Met Thr Phe Leu  Glu Lys Thr 
    2780                 2785                 2790             


Glu Glu  Lys Ala Ala Leu Glu  Asp Gln Val Glu Leu  Cys Ala Lys 
    2795                 2800                 2805             


Lys Leu  Glu Arg Ala Ser Gln  Leu Ile Gly Gly Leu  Gly Gly Glu 
    2810                 2815                 2820             


Lys Ser  Arg Trp Ala Gln Ala  Ala Asp Asp Leu Gln  Ile Thr Tyr 
    2825                 2830                 2835             


Glu Asn  Leu Thr Gly Asp Val  Leu Val Ser Ala Gly  Val Ile Ala 
    2840                 2845                 2850             


Tyr Leu  Gly Ala Phe Thr Ser  Gly Phe Arg Gln Thr  Cys Thr Lys 
    2855                 2860                 2865             


Asp Trp  Ser Met Leu Cys Lys  Lys Lys Lys Ile Pro  Cys Ser Glu 
    2870                 2875                 2880             


Glu Phe  Leu Leu Ser Lys Thr  Leu Gly Asp Pro Val  Lys Ile Arg 
    2885                 2890                 2895             


Ala Trp  Asn Ile Ala Gly Leu  Pro Thr Asp Thr Phe  Ser Ile Asp 
    2900                 2905                 2910             


Asn Gly  Val Ile Val Asn Asn  Cys Arg Arg Trp Pro  Leu Met Ile 
    2915                 2920                 2925             


Asp Pro  Gln Gly Gln Ala Asn  Lys Trp Ile Lys Asn  Ser Glu Lys 
    2930                 2935                 2940             


Glu Asn  Gln Leu Ser Val Ile  Lys Leu Ser Asp Ser  Asp Tyr Met 
    2945                 2950                 2955             


Arg Thr  Leu Glu Asn Cys Ile  Gln Phe Gly Thr Pro  Leu Leu Leu 
    2960                 2965                 2970             


Glu Asn  Val Gly Glu Glu Leu  Asp Pro Ser Leu Glu  Pro Leu Leu 
    2975                 2980                 2985             


Leu Arg  Gln Thr Phe Lys Gln  Gly Gly Ile Asp Cys  Ile Arg Leu 
    2990                 2995                 3000             


Gly Glu  Val Ile Ile Glu Tyr  Ser Phe Asp Phe Lys  Phe Tyr Ile 
    3005                 3010                 3015             


Thr Thr  Lys Leu Arg Asn Pro  His Tyr Met Pro Glu  Leu Ala Thr 
    3020                 3025                 3030             


Lys Val  Ser Leu Leu Asn Phe  Met Ile Thr Pro Glu  Gly Leu Glu 
    3035                 3040                 3045             


Asp Gln  Leu Leu Gly Ile Val  Val Ala Lys Glu Arg  Pro Glu Leu 
    3050                 3055                 3060             


Glu Glu  Glu Arg Asn Ala Leu  Ile Leu Gln Ser Ala  Ala Asn Lys 
    3065                 3070                 3075             


Lys Gln  Leu Lys Asp Ile Glu  Lys Lys Ile Leu Glu  Thr Leu Ser 
    3080                 3085                 3090             


Ser Ser  Glu Gly Asn Ile Leu  Glu Asp Glu Ser Ala  Ile Lys Val 
    3095                 3100                 3105             


Leu Asp  Ser Ala Lys Met Met  Ser Asn Glu Ile Thr  Lys Lys Gln 
    3110                 3115                 3120             


Gln Ile  Ala Glu Lys Thr Glu  Leu Lys Ile Ala Glu  Ser Arg Glu 
    3125                 3130                 3135             


Gly Tyr  Arg Pro Ile Ala Lys  His Ser Ser Val Leu  Phe Phe Ser 
    3140                 3145                 3150             


Ile Ala  Asp Leu Ala Asn Ile  Asp Pro Met Tyr Gln  Tyr Ser Leu 
    3155                 3160                 3165             


Thr Trp  Phe Val Asn Leu Tyr  Ile Asn Ser Ile His  Asp Ser Asn 
    3170                 3175                 3180             


Lys Ser  Lys Ile Leu Glu Lys  Arg Leu Arg Tyr Leu  Asn Asp His 
    3185                 3190                 3195             


Phe Thr  Tyr Asn Leu Tyr Cys  Asn Ile Cys Arg Ser  Leu Phe Glu 
    3200                 3205                 3210             


Lys Asp  Lys Leu Leu Phe Ser  Phe Leu Leu Cys Ala  Asn Leu Leu 
    3215                 3220                 3225             


Leu Ala  Arg Lys Glu Ile Glu  Tyr Gln Glu Leu Met  Phe Leu Leu 
    3230                 3235                 3240             


Thr Gly  Gly Val Ser Leu Lys  Ser Ala Glu Lys Asn  Pro Asp Pro 
    3245                 3250                 3255             


Thr Trp  Leu Gln Asp Lys Ser  Trp Glu Glu Ile Cys  Arg Ala Ser 
    3260                 3265                 3270             


Glu Phe  Pro Ala Phe Arg Gly  Leu Arg Gln His Phe  Cys Glu His 
    3275                 3280                 3285             


Ile Tyr  Glu Trp Arg Glu Ile  Tyr Asp Ser Lys Glu  Pro His Asn 
    3290                 3295                 3300             


Ala Lys  Phe Pro Ala Pro Met  Asp Lys Asn Leu Asn  Glu Leu Gln 
    3305                 3310                 3315             


Lys Ile  Ile Ile Leu Arg Cys  Leu Arg Pro Asp Lys  Ile Thr Pro 
    3320                 3325                 3330             


Ala Ile  Thr Asn Tyr Val Thr  Asp Lys Leu Gly Lys  Lys Phe Val 
    3335                 3340                 3345             


Glu Pro  Pro Pro Phe Asp Leu  Thr Lys Ser Tyr Leu  Asp Ser Asn 
    3350                 3355                 3360             


Cys Thr  Ile Pro Leu Ile Phe  Val Leu Ser Pro Gly  Ala Asp Pro 
    3365                 3370                 3375             


Met Ala  Ser Leu Leu Lys Phe  Ala Asn Asp Lys Ser  Met Ser Gly 
    3380                 3385                 3390             


Asn Lys  Phe Gln Ala Ile Ser  Leu Gly Gln Gly Gln  Gly Pro Ile 
    3395                 3400                 3405             


Ala Ala  Lys Met Ile Lys Ala  Ala Ile Glu Glu Gly  Thr Trp Val 
    3410                 3415                 3420             


Cys Leu  Gln Asn Cys His Leu  Ala Val Ser Trp Met  Pro Met Leu 
    3425                 3430                 3435             


Glu Lys  Ile Cys Glu Asp Phe  Thr Ser Glu Thr Cys  Asn Ser Ser 
    3440                 3445                 3450             


Phe Arg  Leu Trp Leu Thr Ser  Tyr Pro Ser Ser Lys  Phe Pro Val 
    3455                 3460                 3465             


Thr Ile  Leu Gln Asn Gly Val  Lys Met Thr Asn Glu  Pro Pro Thr 
    3470                 3475                 3480             


Gly Leu  Arg Leu Asn Leu Leu  Gln Ser Tyr Leu Thr  Asp Pro Val 
    3485                 3490                 3495             


Ser Asp  Pro Glu Phe Phe Lys  Gly Cys Arg Gly Lys  Glu Leu Ala 
    3500                 3505                 3510             


Trp Glu  Lys Leu Leu Phe Gly  Val Cys Phe Phe His  Ala Leu Val 
    3515                 3520                 3525             


Gln Glu  Arg Lys Lys Phe Gly  Pro Leu Gly Trp Asn  Ile Pro Tyr 
    3530                 3535                 3540             


Gly Phe  Asn Glu Ser Asp Leu  Arg Ile Ser Ile Arg  Gln Leu Gln 
    3545                 3550                 3555             


Leu Phe  Ile Asn Glu Tyr Asp  Thr Ile Pro Phe Glu  Ala Ile Ser 
    3560                 3565                 3570             


Tyr Leu  Thr Gly Glu Cys Asn  Tyr Gly Gly Arg Val  Thr Asp Asp 
    3575                 3580                 3585             


Trp Asp  Arg Arg Leu Leu Leu  Thr Met Leu Ala Asp  Phe Tyr Asn 
    3590                 3595                 3600             


Leu Tyr  Ile Val Glu Asn Pro  His Tyr Lys Phe Ser  Pro Ser Gly 
    3605                 3610                 3615             


Asn Tyr  Phe Ala Pro Pro Lys  Gly Thr Tyr Glu Asp  Tyr Ile Glu 
    3620                 3625                 3630             


Phe Ile  Lys Lys Leu Pro Phe  Thr Gln His Pro Glu  Ile Phe Gly 
    3635                 3640                 3645             


Leu His  Glu Asn Val Asp Ile  Ser Lys Asp Leu Gln  Gln Thr Lys 
    3650                 3655                 3660             


Thr Leu  Phe Glu Ser Leu Leu  Leu Thr Gln Gly Gly  Ser Lys Gln 
    3665                 3670                 3675             


Thr Gly  Ala Ser Gly Ser Thr  Asp Gln Ile Leu Leu  Glu Ile Thr 
    3680                 3685                 3690             


Lys Asp  Ile Leu Asn Lys Leu  Pro Ser Asp Phe Asp  Ile Glu Met 
    3695                 3700                 3705             


Ala Leu  Arg Lys Tyr Pro Val  Arg Tyr Glu Glu Ser  Met Asn Thr 
    3710                 3715                 3720             


Val Leu  Val Gln Glu Met Glu  Arg Phe Asn Asn Leu  Ile Ile Thr 
    3725                 3730                 3735             


Ile Arg  Asn Thr Leu Arg Asp  Leu Glu Lys Ala Ile  Lys Gly Val 
    3740                 3745                 3750             


Val Val  Met Asp Ser Ala Leu  Glu Ala Leu Ser Gly  Ser Leu Leu 
    3755                 3760                 3765             


Val Gly  Lys Val Pro Glu Ile  Trp Ala Lys Arg Ser  Tyr Pro Ser 
    3770                 3775                 3780             


Leu Lys  Pro Leu Gly Ser Tyr  Ile Thr Asp Phe Leu  Ala Arg Leu 
    3785                 3790                 3795             


Asn Phe  Leu Gln Asp Trp Tyr  Asn Ser Gly Lys Pro  Cys Val Phe 
    3800                 3805                 3810             


Trp Leu  Ser Gly Phe Phe Phe  Thr Gln Ala Phe Leu  Thr Gly Ala 
    3815                 3820                 3825             


Met Gln  Asn Tyr Ala Arg Lys  Tyr Thr Thr Pro Ile  Asp Leu Leu 
    3830                 3835                 3840             


Gly Tyr  Glu Phe Glu Val Ile  Pro Ser Asp Thr Ser  Asp Thr Ser 
    3845                 3850                 3855             


Pro Glu  Asp Gly Val Tyr Ile  His Gly Leu Tyr Leu  Asp Gly Ala 
    3860                 3865                 3870             


Arg Trp  Asp Arg Glu Ser Gly  Leu Leu Ala Glu Gln  Tyr Pro Lys 
    3875                 3880                 3885             


Leu Leu  Phe Asp Leu Met Pro  Ile Ile Trp Ile Lys  Pro Thr Gln 
    3890                 3895                 3900             


Lys Ser  Arg Ile Ile Lys Ser  Asp Ala Tyr Val Cys  Pro Leu Tyr 
    3905                 3910                 3915             


Lys Thr  Ser Glu Arg Lys Gly  Thr Leu Ser Thr Thr  Gly His Ser 
    3920                 3925                 3930             


Thr Asn  Phe Val Ile Ala Met  Leu Leu Lys Thr Asp  Gln Pro Thr 
    3935                 3940                 3945             


Arg His  Trp Ile Lys Arg Gly  Val Ala Leu Leu Cys  Gln Leu Asp 
    3950                 3955                 3960             


Asp 
    


<210>  3140
<211>  4462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH17__Homo_sapiens__NP_775899

<400>  3140

Met Thr Met Ala Pro Asp Val Arg Leu Glu Tyr Leu Glu Glu Val Ala 
1               5                   10                  15      


Ser Ile Val Leu Lys Phe Lys Pro Asp Lys Trp Ser Lys Leu Ile Gly 
            20                  25                  30          


Ala Glu Glu Asn Val Ala Leu Phe Thr Glu Phe Phe Glu Lys Pro Asp 
        35                  40                  45              


Val Gln Val Leu Val Leu Thr Leu Asn Ala Ala Gly Met Ile Ile Pro 
    50                  55                  60                  


Cys Leu Gly Phe Pro Gln Ser Leu Lys Ser Lys Gly Val Tyr Phe Ile 
65                  70                  75                  80  


Lys Thr Lys Ser Glu Asn Ile Asn Lys Asp Asn Tyr Arg Ala Arg Leu 
                85                  90                  95      


Leu Tyr Gly Asp Ile Ser Pro Thr Pro Val Asp Gln Leu Ile Ala Val 
            100                 105                 110         


Val Glu Glu Val Leu Ser Ser Leu Leu Asn Gln Ser Glu Asn Met Ala 
        115                 120                 125             


Gly Trp Pro Gln Val Val Ser Glu Asp Ile Val Lys Gln Val His Arg 
    130                 135                 140                 


Leu Lys Asn Glu Met Phe Val Met Ser Gly Lys Ile Lys Gly Lys Thr 
145                 150                 155                 160 


Leu Leu Pro Ile Pro Glu His Leu Gly Ser Leu Asp Gly Thr Leu Glu 
                165                 170                 175     


Ser Met Glu Arg Ile Pro Ser Ser Leu Asp Asn Leu Leu Leu His Ala 
            180                 185                 190         


Ile Glu Thr Thr Ile Ile Asp Trp Ser His Gln Ile Arg Asp Val Leu 
        195                 200                 205             


Ser Lys Asp Ser Ala Gln Ala Leu Leu Asp Gly Leu His Pro Leu Pro 
    210                 215                 220                 


Gln Val Glu Phe Glu Phe Trp Asp Thr Arg Leu Leu Asn Leu Lys Cys 
225                 230                 235                 240 


Ile His Glu Gln Leu Asn Arg Pro Lys Val Asn Lys Ile Val Glu Ile 
                245                 250                 255     


Leu Glu Lys Ala Lys Ser Cys Tyr Trp Pro Ala Leu Gln Asn Val Tyr 
            260                 265                 270         


Thr Asn Val Thr Glu Gly Leu Lys Glu Ala Asn Asp Ile Val Leu Tyr 
        275                 280                 285             


Leu Lys Pro Leu Arg Ile Leu Leu Glu Glu Met Glu Gln Ala Asp Phe 
    290                 295                 300                 


Thr Met Leu Pro Thr Phe Ile Ala Lys Val Leu Asp Thr Ile Cys Phe 
305                 310                 315                 320 


Ile Trp Ala Thr Ser Glu Tyr Tyr Asn Thr Pro Ala Arg Ile Ile Val 
                325                 330                 335     


Ile Leu Gln Glu Phe Cys Asn Gln Ile Ile Glu Met Thr Arg Thr Phe 
            340                 345                 350         


Leu Ser Pro Glu Glu Val Leu Lys Gly Leu Gln Gly Glu Ile Glu Glu 
        355                 360                 365             


Val Leu Ser Gly Ile Ser Leu Ala Val Asn Val Leu Lys Glu Leu Tyr 
    370                 375                 380                 


Gln Thr Tyr Asp Phe Cys Cys Val Asn Met Lys Leu Phe Phe Lys Asp 
385                 390                 395                 400 


Lys Glu Pro Val Pro Trp Glu Phe Pro Ser Ser Leu Ala Phe Ser Arg 
                405                 410                 415     


Ile Asn Ser Phe Phe Gln Arg Ile Gln Thr Ile Glu Glu Leu Tyr Lys 
            420                 425                 430         


Thr Ala Ile Glu Phe Leu Lys Leu Glu Lys Ile Glu Leu Gly Gly Val 
        435                 440                 445             


Arg Gly Asn Leu Leu Gly Ser Leu Val Thr Arg Ile Tyr Asp Glu Val 
    450                 455                 460                 


Phe Glu Leu Val Lys Val Phe Ala Asp Cys Lys Tyr Asp Pro Leu Asp 
465                 470                 475                 480 


Pro Gly Asp Ser Asn Phe Asp Arg Asp Tyr Ala Asp Phe Glu Ile Lys 
                485                 490                 495     


Ile Gln Asp Leu Asp Arg Arg Leu Ala Thr Ile Phe Cys Gln Gly Phe 
            500                 505                 510         


Asp Asp Cys Ser Cys Ile Lys Ser Ser Ala Lys Leu Leu Tyr Met Cys 
        515                 520                 525             


Gly Gly Leu Met Glu Arg Pro Leu Ile Leu Ala Glu Val Ala Pro Arg 
    530                 535                 540                 


Tyr Ser Val Met Leu Glu Leu Phe Asp Ala Glu Leu Asp Asn Ala Lys 
545                 550                 555                 560 


Ile Leu Tyr Asp Ala Gln Met Ala Ala Ser Glu Glu Gly Asn Ile Pro 
                565                 570                 575     


Leu Ile His Lys Asn Met Pro Pro Val Ala Gly Gln Leu Lys Trp Ser 
            580                 585                 590         


Leu Glu Leu Gln Glu Arg Leu Glu Val Ser Met Lys His Leu Lys His 
        595                 600                 605             


Val Glu His Pro Val Met Ser Gly Ala Glu Ala Lys Leu Thr Tyr Gln 
    610                 615                 620                 


Lys Tyr Asp Glu Met Met Glu Leu Leu Arg Cys His Arg Glu Lys Ile 
625                 630                 635                 640 


Tyr Gln Gln Trp Val Ala Gly Val Asp Gln Asp Cys His Phe Asn Leu 
                645                 650                 655     


Gly Gln Pro Leu Ile Leu Arg Asp Ala Ala Ser Asn Leu Ile His Val 
            660                 665                 670         


Asn Phe Ser Lys Ala Leu Val Ala Val Leu Arg Glu Val Lys Tyr Leu 
        675                 680                 685             


Asn Phe Gln Gln Gln Lys Glu Ile Pro Asp Ser Ala Glu Ser Leu Phe 
    690                 695                 700                 


Ser Glu Asn Glu Thr Phe Arg Lys Phe Val Gly Asn Leu Glu Leu Ile 
705                 710                 715                 720 


Val Gly Trp Tyr Asn Glu Ile Lys Thr Ile Val Lys Ala Val Glu Phe 
                725                 730                 735     


Leu Leu Ile Lys Ser Glu Leu Glu Ala Ile Asp Val Lys Leu Leu Ser 
            740                 745                 750         


Ala Glu Thr Thr Leu Phe Trp Asn Gly Glu Gly Val Phe Gln Tyr Ile 
        755                 760                 765             


Gln Glu Val Arg Glu Ile Leu His Asn Leu Gln Asn Arg Met Gln Lys 
    770                 775                 780                 


Ala Lys Gln Asn Ile Glu Gly Ile Ser Gln Ala Met Lys Asp Trp Ser 
785                 790                 795                 800 


Ala Asn Pro Leu Phe Glu Arg Lys Asp Asn Lys Lys Glu Ala Leu Leu 
                805                 810                 815     


Asp Leu Asp Gly Arg Ile Ala Asn Leu Asn Lys Arg Tyr Ala Ala Val 
            820                 825                 830         


Arg Asp Ala Gly Val Lys Ile Gln Ala Met Val Ala Glu Asn Ala Glu 
        835                 840                 845             


Leu Phe Arg Ala Asp Thr Leu Ser Leu Pro Trp Lys Asp Tyr Val Ile 
    850                 855                 860                 


Tyr Ile Asp Asp Met Val Leu Asp Glu Phe Asp Gln Phe Ile Arg Lys 
865                 870                 875                 880 


Ser Leu Ser Phe Leu Met Asp Asn Met Val Ile Asp Glu Ser Ile Ala 
                885                 890                 895     


Pro Leu Phe Glu Ile Arg Met Glu Leu Asp Glu Asp Gly Leu Thr Phe 
            900                 905                 910         


Asn Pro Thr Leu Glu Val Gly Ser Asp Arg Gly Phe Leu Ala Leu Ile 
        915                 920                 925             


Glu Gly Leu Val Asn Asp Ile Tyr Asn Val Ala Arg Leu Ile Pro Arg 
    930                 935                 940                 


Leu Ala Lys Asp Arg Met Asn Tyr Lys Met Asp Leu Glu Asp Asn Thr 
945                 950                 955                 960 


Asp Leu Ile Glu Met Arg Glu Glu Val Ser Ser Leu Val Ile Asn Ala 
                965                 970                 975     


Met Lys Glu Ala Glu Glu Tyr Gln Asp Ser Phe Glu Arg Tyr Ser Tyr 
            980                 985                 990         


Leu Trp Thr Asp Asn Leu Gln Glu  Phe Met Lys Asn Phe  Leu Ile Tyr 
        995                 1000                 1005             


Gly Cys  Ala Val Thr Ala Glu  Asp Leu Asp Thr Trp  Thr Asp Asp 
    1010                 1015                 1020             


Thr Ile  Pro Lys Thr Pro Pro  Thr Leu Ala Gln Phe  Gln Glu Gln 
    1025                 1030                 1035             


Ile Asp  Ser Tyr Glu Lys Leu  Tyr Glu Glu Val Ser  Lys Cys Glu 
    1040                 1045                 1050             


Asn Thr  Lys Val Phe His Gly  Trp Leu Gln Cys Asp  Cys Arg Pro 
    1055                 1060                 1065             


Phe Lys  Gln Ala Leu Leu Ser  Thr Ile Arg Arg Trp  Gly Phe Met 
    1070                 1075                 1080             


Phe Lys  Arg His Leu Ser Asn  His Val Thr Asn Ser  Leu Ala Asp 
    1085                 1090                 1095             


Leu Glu  Ala Phe Met Lys Val  Ala Arg Met Gly Leu  Thr Lys Pro 
    1100                 1105                 1110             


Leu Lys  Glu Gly Asp Tyr Asp  Gly Leu Val Glu Val  Met Gly His 
    1115                 1120                 1125             


Leu Met  Lys Val Lys Glu Arg  Gln Ala Ala Thr Asp  Asn Met Phe 
    1130                 1135                 1140             


Glu Pro  Leu Lys Gln Thr Ile  Glu Leu Leu Lys Thr  Tyr Gly Glu 
    1145                 1150                 1155             


Glu Met  Pro Glu Glu Ile His  Leu Lys Leu Gln Glu  Leu Pro Glu 
    1160                 1165                 1170             


His Trp  Ala Asn Thr Lys Lys  Leu Ala Ile Gln Val  Lys Leu Thr 
    1175                 1180                 1185             


Val Ala  Pro Leu Gln Ala Asn  Glu Val Ser Ile Leu  Arg Arg Lys 
    1190                 1195                 1200             


Cys Gln  Gln Phe Glu Leu Lys  Gln His Glu Phe Arg  Glu Arg Phe 
    1205                 1210                 1215             


Arg Arg  Glu Ala Pro Phe Ser  Phe Ser Asp Pro Asn  Pro Tyr Lys 
    1220                 1225                 1230             


Ser Leu  Asn Lys Gln Gln Lys  Ser Ile Ser Ala Met  Glu Gly Ile 
    1235                 1240                 1245             


Met Glu  Ala Leu Ser Lys Ser  Gly Gly Leu Phe Glu  Val Pro Val 
    1250                 1255                 1260             


Pro Asp  Tyr Lys Gln Leu Lys  Ala Cys His Arg Glu  Val Arg Leu 
    1265                 1270                 1275             


Leu Lys  Glu Leu Trp Asp Met  Val Val Val Val Asn  Thr Ser Ile 
    1280                 1285                 1290             


Glu Asp  Trp Lys Thr Thr Lys  Trp Lys Asp Ile Asn  Val Glu Gln 
    1295                 1300                 1305             


Met Asp  Ile Asp Cys Lys Lys  Phe Ala Lys Asp Met  Arg Ser Leu 
    1310                 1315                 1320             


Asp Lys  Glu Met Lys Thr Trp  Asp Ala Phe Val Gly  Leu Asp Asn 
    1325                 1330                 1335             


Thr Val  Lys Asn Val Ile Thr  Ser Leu Arg Ala Val  Ser Glu Leu 
    1340                 1345                 1350             


Gln Asn  Pro Ala Ile Arg Glu  Arg His Trp Gln Gln  Leu Met Gln 
    1355                 1360                 1365             


Ala Thr  Gln Val Lys Phe Lys  Met Ser Glu Glu Thr  Thr Leu Ala 
    1370                 1375                 1380             


Asp Leu  Leu Gln Leu Asn Leu  His Ser Tyr Glu Asp  Glu Val Arg 
    1385                 1390                 1395             


Asn Ile  Val Asp Lys Ala Val  Lys Glu Ser Gly Met  Glu Lys Val 
    1400                 1405                 1410             


Leu Lys  Ala Leu Asp Ser Thr  Trp Ser Met Met Glu  Phe Gln His 
    1415                 1420                 1425             


Glu Pro  His Pro Arg Thr Gly  Thr Met Met Leu Lys  Ser Ser Glu 
    1430                 1435                 1440             


Val Leu  Val Glu Thr Leu Glu  Asp Asn Gln Val Gln  Leu Gln Asn 
    1445                 1450                 1455             


Leu Met  Met Ser Lys Tyr Leu  Ala His Phe Leu Lys  Glu Val Thr 
    1460                 1465                 1470             


Ser Trp  Gln Gln Lys Leu Ser  Thr Ala Asp Ser Val  Ile Ser Ile 
    1475                 1480                 1485             


Trp Phe  Glu Val Gln Arg Thr  Trp Ser His Leu Glu  Ser Ile Phe 
    1490                 1495                 1500             


Ile Gly  Ser Glu Asp Ile Arg  Thr Gln Leu Pro Gly  Asp Ser Gln 
    1505                 1510                 1515             


Arg Phe  Asp Asp Ile Asn Gln  Glu Phe Lys Ala Leu  Met Glu Asp 
    1520                 1525                 1530             


Ala Val  Lys Thr Pro Asn Val  Val Glu Ala Thr Ser  Lys Pro Gly 
    1535                 1540                 1545             


Leu Tyr  Asn Lys Leu Glu Ala  Leu Lys Lys Ser Leu  Ala Ile Cys 
    1550                 1555                 1560             


Glu Lys  Ala Leu Ala Glu Tyr  Leu Glu Thr Lys Arg  Leu Ala Phe 
    1565                 1570                 1575             


Pro Arg  Phe Tyr Phe Val Ser  Ser Ala Asp Leu Leu  Asp Ile Leu 
    1580                 1585                 1590             


Ser Asn  Gly Asn Asp Pro Val  Glu Val Ser Arg His  Leu Ser Lys 
    1595                 1600                 1605             


Leu Phe  Asp Ser Leu Cys Lys  Leu Lys Phe Arg Leu  Asp Ala Ser 
    1610                 1615                 1620             


Asp Lys  Pro Leu Lys Val Gly  Leu Gly Met Tyr Ser  Lys Glu Asp 
    1625                 1630                 1635             


Glu Tyr  Met Val Phe Asp Gln  Glu Cys Asp Leu Ser  Gly Gln Val 
    1640                 1645                 1650             


Glu Val  Trp Leu Asn Arg Val  Leu Asp Arg Met Cys  Ser Thr Leu 
    1655                 1660                 1665             


Arg His  Glu Ile Pro Glu Ala  Val Val Thr Tyr Glu  Glu Lys Pro 
    1670                 1675                 1680             


Arg Glu  Gln Trp Ile Leu Asp  Tyr Pro Ala Gln Val  Ala Leu Thr 
    1685                 1690                 1695             


Cys Thr  Gln Ile Trp Trp Thr  Thr Glu Val Gly Leu  Ala Phe Ala 
    1700                 1705                 1710             


Arg Leu  Glu Glu Gly Tyr Glu  Asn Ala Ile Arg Asp  Tyr Asn Lys 
    1715                 1720                 1725             


Lys Gln  Ile Ser Gln Leu Asn  Val Leu Ile Thr Leu  Leu Met Gly 
    1730                 1735                 1740             


Asn Leu  Asn Ala Gly Asp Arg  Met Lys Ile Met Thr  Ile Cys Thr 
    1745                 1750                 1755             


Ile Asp  Val His Ala Arg Asp  Val Val Ala Lys Met  Ile Val Ala 
    1760                 1765                 1770             


Lys Val  Glu Ser Ser Gln Ala  Phe Thr Trp Gln Ala  Gln Leu Arg 
    1775                 1780                 1785             


His Arg  Trp Asp Glu Glu Lys  Arg His Cys Phe Ala  Asn Ile Cys 
    1790                 1795                 1800             


Asp Ala  Gln Ile Gln Tyr Ser  Tyr Glu Tyr Leu Gly  Asn Thr Pro 
    1805                 1810                 1815             


Arg Leu  Val Ile Thr Pro Leu  Thr Asp Arg Cys Tyr  Ile Thr Leu 
    1820                 1825                 1830             


Thr Gln  Ser Leu His Leu Ile  Met Gly Gly Ala Pro  Ala Gly Pro 
    1835                 1840                 1845             


Ala Gly  Thr Gly Lys Thr Glu  Thr Thr Lys Asp Leu  Gly Arg Ala 
    1850                 1855                 1860             


Leu Gly  Thr Met Val Tyr Val  Phe Asn Cys Ser Glu  Gln Met Asp 
    1865                 1870                 1875             


Tyr Lys  Ser Cys Gly Asn Ile  Tyr Lys Gly Leu Ala  Gln Thr Gly 
    1880                 1885                 1890             


Ala Trp  Gly Cys Phe Asp Glu  Phe Asn Arg Ile Ser  Val Glu Val 
    1895                 1900                 1905             


Leu Ser  Val Ile Ala Val Gln  Val Lys Cys Val Gln  Asp Ala Ile 
    1910                 1915                 1920             


Arg Ala  Lys Lys Lys Ala Phe  Asn Phe Leu Gly Glu  Ile Ile Gly 
    1925                 1930                 1935             


Leu Ile  Pro Thr Val Gly Ile  Phe Ile Thr Met Asn  Pro Gly Tyr 
    1940                 1945                 1950             


Ala Gly  Arg Ala Glu Leu Pro  Glu Asn Leu Lys Ala  Leu Phe Arg 
    1955                 1960                 1965             


Pro Cys  Ala Met Val Val Pro  Asp Phe Glu Leu Ile  Cys Glu Ile 
    1970                 1975                 1980             


Met Leu  Met Ala Glu Gly Phe  Leu Glu Ala Arg Leu  Leu Ala Arg 
    1985                 1990                 1995             


Lys Phe  Ile Thr Leu Tyr Thr  Leu Cys Lys Glu Leu  Leu Ser Lys 
    2000                 2005                 2010             


Gln Asp  His Tyr Asp Trp Gly  Leu Arg Ala Ile Lys  Ser Val Leu 
    2015                 2020                 2025             


Val Val  Ala Gly Ser Leu Lys  Arg Gly Asp Pro Ser  Arg Ala Glu 
    2030                 2035                 2040             


Asp Gln  Val Leu Met Arg Ala  Leu Arg Asp Phe Asn  Ile Pro Lys 
    2045                 2050                 2055             


Ile Val  Thr Asp Asp Leu Pro  Val Phe Met Gly Leu  Ile Gly Asp 
    2060                 2065                 2070             


Leu Phe  Pro Ala Leu Asp Val  Pro Arg Lys Arg Asp  Leu Asn Phe 
    2075                 2080                 2085             


Glu Lys  Ile Ile Lys Gln Ser  Ile Val Glu Leu Lys  Leu Gln Ala 
    2090                 2095                 2100             


Glu Asp  Ser Phe Val Leu Lys  Val Val Gln Leu Glu  Glu Leu Leu 
    2105                 2110                 2115             


Gln Val  Arg His Ser Val Phe  Ile Val Gly Asn Ala  Gly Ser Gly 
    2120                 2125                 2130             


Lys Ser  Gln Val Leu Lys Ser  Leu Asn Lys Thr Tyr  Gln Asn Leu 
    2135                 2140                 2145             


Lys Arg  Lys Pro Val Ala Val  Asp Leu Asp Pro Lys  Ala Val Thr 
    2150                 2155                 2160             


Cys Asp  Glu Leu Phe Gly Ile  Ile Asn Pro Val Thr  Arg Glu Trp 
    2165                 2170                 2175             


Lys Asp  Gly Leu Phe Ser Thr  Ile Met Arg Asp Leu  Ala Asn Ile 
    2180                 2185                 2190             


Thr His  Asp Gly Pro Lys Trp  Ile Ile Leu Asp Gly  Asp Ile Asp 
    2195                 2200                 2205             


Pro Met  Trp Ile Glu Ser Leu  Asn Thr Val Met Asp  Asp Asn Lys 
    2210                 2215                 2220             


Val Leu  Thr Leu Ala Ser Asn  Glu Arg Ile Pro Leu  Asn Arg Thr 
    2225                 2230                 2235             


Met Arg  Leu Val Phe Glu Ile  Ser His Leu Arg Thr  Ala Thr Pro 
    2240                 2245                 2250             


Ala Thr  Val Ser Arg Ala Gly  Ile Leu Tyr Ile Asn  Pro Ala Asp 
    2255                 2260                 2265             


Leu Gly  Trp Asn Pro Val Val  Ser Ser Trp Ile Glu  Arg Arg Lys 
    2270                 2275                 2280             


Val Gln  Ser Glu Lys Ala Asn  Leu Met Ile Leu Phe  Asp Lys Tyr 
    2285                 2290                 2295             


Leu Pro  Thr Cys Leu Asp Lys  Leu Arg Phe Gly Phe  Lys Lys Ile 
    2300                 2305                 2310             


Thr Pro  Val Pro Glu Ile Thr  Val Ile Gln Thr Ile  Leu Tyr Leu 
    2315                 2320                 2325             


Leu Glu  Cys Leu Leu Thr Glu  Lys Thr Val Pro Pro  Asp Ser Pro 
    2330                 2335                 2340             


Arg Glu  Leu Tyr Glu Leu Tyr  Phe Val Phe Thr Cys  Phe Trp Ala 
    2345                 2350                 2355             


Phe Gly  Gly Ala Met Phe Gln  Asp Gln Leu Val Asp  Tyr Arg Val 
    2360                 2365                 2370             


Glu Phe  Ser Lys Trp Trp Ile  Asn Glu Phe Lys Thr  Ile Lys Phe 
    2375                 2380                 2385             


Pro Ser  Gln Gly Thr Ile Phe  Asp Tyr Tyr Ile Asp  Pro Asp Thr 
    2390                 2395                 2400             


Lys Lys  Phe Leu Pro Trp Thr  Asp Lys Val Pro Ser  Phe Glu Leu 
    2405                 2410                 2415             


Asp Pro  Asp Val Pro Leu Gln  Ala Ser Leu Val His  Thr Thr Glu 
    2420                 2425                 2430             


Thr Ile  Arg Ile Arg Tyr Phe  Met Asp Leu Leu Met  Glu Lys Ser 
    2435                 2440                 2445             


Trp Pro  Val Met Leu Val Gly  Asn Ala Gly Thr Gly  Lys Ser Val 
    2450                 2455                 2460             


Leu Met  Gly Asp Lys Leu Glu  Ser Leu Asn Thr Asp  Asn Tyr Leu 
    2465                 2470                 2475             


Val Gln  Ala Val Pro Phe Asn  Phe Tyr Thr Thr Ser  Ala Met Leu 
    2480                 2485                 2490             


Gln Gly  Val Leu Glu Lys Pro  Leu Glu Lys Lys Ser  Gly Arg Asn 
    2495                 2500                 2505             


Tyr Gly  Pro Pro Gly Thr Lys  Lys Leu Val Tyr Phe  Ile Asp Asp 
    2510                 2515                 2520             


Met Asn  Met Pro Glu Val Asp  Lys Tyr Gly Thr Val  Ala Pro His 
    2525                 2530                 2535             


Thr Leu  Ile Arg Gln His Met  Asp His Arg His Trp  Tyr Asp Arg 
    2540                 2545                 2550             


His Lys  Leu Thr Leu Lys Asp  Ile His Asn Cys Gln  Tyr Val Ala 
    2555                 2560                 2565             


Cys Met  Asn Pro Thr Ser Gly  Ser Phe Thr Ile Asp  Ser Arg Leu 
    2570                 2575                 2580             


Gln Arg  His Phe Cys Val Phe  Ala Val Ser Phe Pro  Gly Gln Glu 
    2585                 2590                 2595             


Ala Leu  Thr Thr Ile Tyr Asn  Thr Ile Leu Thr Gln  His Leu Ala 
    2600                 2605                 2610             


Phe Arg  Ser Val Ser Met Ala  Ile Gln Arg Ile Ser  Ser Gln Leu 
    2615                 2620                 2625             


Val Ala  Ala Ala Leu Ala Leu  His Gln Lys Ile Thr  Ala Thr Phe 
    2630                 2635                 2640             


Leu Pro  Thr Ala Ile Lys Phe  His Tyr Val Phe Asn  Leu Arg Asp 
    2645                 2650                 2655             


Leu Ser  Asn Ile Phe Gln Gly  Leu Leu Phe Ser Thr  Ala Glu Val 
    2660                 2665                 2670             


Leu Lys  Thr Pro Leu Asp Leu  Val Arg Leu Trp Leu  His Glu Thr 
    2675                 2680                 2685             


Glu Arg  Val Tyr Gly Asp Lys  Met Val Asp Glu Lys  Asp Gln Glu 
    2690                 2695                 2700             


Thr Leu  His Arg Val Thr Met  Ala Ser Thr Lys Lys  Phe Phe Asp 
    2705                 2710                 2715             


Asp Leu  Gly Asp Glu Leu Leu  Phe Ala Lys Pro Asn  Ile Phe Cys 
    2720                 2725                 2730             


His Phe  Ala Gln Gly Ile Gly  Asp Pro Lys Tyr Val  Pro Val Thr 
    2735                 2740                 2745             


Asp Met  Ala Pro Leu Asn Lys  Leu Leu Val Asp Val  Leu Asp Ser 
    2750                 2755                 2760             


Tyr Asn  Glu Val Asn Ala Val  Met Asn Leu Val Leu  Phe Glu Asp 
    2765                 2770                 2775             


Ala Val  Ala His Ile Cys Arg  Ile Asn Arg Ile Leu  Glu Ser Pro 
    2780                 2785                 2790             


Arg Gly  Asn Ala Leu Leu Val  Gly Val Gly Gly Ser  Gly Lys Gln 
    2795                 2800                 2805             


Ser Leu  Ser Arg Leu Ala Ala  Tyr Ile Ser Gly Leu  Asp Val Phe 
    2810                 2815                 2820             


Gln Ile  Thr Leu Lys Lys Gly  Tyr Gly Ile Pro Asp  Leu Lys Ile 
    2825                 2830                 2835             


Asp Leu  Ala Ala Gln Tyr Ile  Lys Ala Ala Val Lys  Asn Val Pro 
    2840                 2845                 2850             


Ser Val  Phe Leu Met Thr Asp  Ser Gln Val Ala Glu  Glu Gln Phe 
    2855                 2860                 2865             


Leu Val  Leu Ile Asn Asp Leu  Leu Ala Ser Gly Glu  Ile Pro Gly 
    2870                 2875                 2880             


Leu Phe  Met Glu Asp Glu Val  Glu Asn Ile Ile Ser  Ser Met Arg 
    2885                 2890                 2895             


Pro Gln  Val Lys Ser Leu Gly  Met Asn Asp Thr Arg  Glu Thr Cys 
    2900                 2905                 2910             


Trp Lys  Phe Phe Ile Glu Lys  Val Arg Arg Gln Leu  Lys Val Ile 
    2915                 2920                 2925             


Leu Cys  Phe Ser Pro Val Gly  Ser Val Leu Arg Val  Arg Ala Arg 
    2930                 2935                 2940             


Lys Phe  Pro Ala Val Val Asn  Cys Thr Ala Ile Asp  Trp Phe His 
    2945                 2950                 2955             


Glu Trp  Pro Glu Asp Ala Leu  Val Ser Val Ser Ala  Arg Phe Leu 
    2960                 2965                 2970             


Glu Glu  Thr Glu Gly Ile Pro  Trp Glu Val Lys Ala  Ser Ile Ser 
    2975                 2980                 2985             


Phe Phe  Met Ser Tyr Val His  Thr Thr Val Asn Glu  Met Ser Arg 
    2990                 2995                 3000             


Val Tyr  Leu Ala Thr Glu Arg  Arg Tyr Asn Tyr Thr  Thr Pro Lys 
    3005                 3010                 3015             


Thr Phe  Leu Glu Gln Ile Lys  Leu Tyr Gln Asn Leu  Leu Ala Lys 
    3020                 3025                 3030             


Lys Arg  Thr Glu Leu Val Ala  Lys Ile Glu Arg Leu  Glu Asn Gly 
    3035                 3040                 3045             


Leu Met  Lys Leu Gln Ser Thr  Ala Ser Gln Val Asp  Asp Leu Lys 
    3050                 3055                 3060             


Ala Lys  Leu Ala Ile Gln Glu  Ala Glu Leu Lys Gln  Lys Asn Glu 
    3065                 3070                 3075             


Ser Ala  Asp Gln Leu Ile Gln  Val Val Gly Ile Glu  Ala Glu Lys 
    3080                 3085                 3090             


Val Ser  Lys Glu Lys Ala Ile  Ala Asp Gln Glu Glu  Val Lys Val 
    3095                 3100                 3105             


Glu Val  Ile Asn Lys Asn Val  Thr Glu Lys Gln Lys  Ala Cys Glu 
    3110                 3115                 3120             


Thr Asp  Leu Ala Lys Ala Glu  Pro Ala Leu Leu Ala  Ala Gln Glu 
    3125                 3130                 3135             


Ala Leu  Asp Thr Leu Asn Lys  Asn Asn Leu Thr Glu  Leu Lys Ser 
    3140                 3145                 3150             


Phe Gly  Ser Pro Pro Asp Ala  Val Val Asn Val Thr  Ala Ala Val 
    3155                 3160                 3165             


Met Ile  Leu Thr Ala Pro Gly  Gly Lys Ile Pro Lys  Asp Lys Ser 
    3170                 3175                 3180             


Trp Lys  Ala Ala Lys Ile Met  Met Gly Lys Val Asp  Thr Phe Leu 
    3185                 3190                 3195             


Asp Ser  Leu Lys Lys Phe Asp  Lys Glu His Ile Pro  Glu Ala Cys 
    3200                 3205                 3210             


Leu Lys  Ala Phe Lys Pro Tyr  Gln Gly Asn Pro Thr  Phe Asp Pro 
    3215                 3220                 3225             


Glu Phe  Ile Arg Ser Lys Ser  Thr Ala Ala Ala Gly  Leu Cys Ser 
    3230                 3235                 3240             


Trp Cys  Ile Asn Ile Val Arg  Phe Tyr Glu Val Tyr  Cys Asp Val 
    3245                 3250                 3255             


Ala Pro  Lys Arg Gln Ala Leu  Glu Glu Ala Asn Ala  Glu Leu Ala 
    3260                 3265                 3270             


Glu Ala  Gln Glu Lys Leu Ser  Arg Ile Lys Asn Lys  Ile Ala Glu 
    3275                 3280                 3285             


Leu Asn  Ala Asn Leu Ser Asn  Leu Thr Ser Ala Phe  Glu Lys Ala 
    3290                 3295                 3300             


Thr Ala  Glu Lys Ile Lys Cys  Gln Gln Glu Ala Asp  Ala Thr Asn 
    3305                 3310                 3315             


Arg Val  Ile Leu Leu Ala Asn  Arg Leu Val Gly Gly  Leu Ala Ser 
    3320                 3325                 3330             


Glu Asn  Ile Arg Trp Ala Glu  Ser Val Glu Asn Phe  Arg Ser Gln 
    3335                 3340                 3345             


Gly Val  Thr Leu Cys Gly Asp  Val Leu Leu Ile Ser  Ala Phe Val 
    3350                 3355                 3360             


Ser Tyr  Val Gly Tyr Phe Thr  Lys Lys Tyr Arg Asn  Glu Leu Met 
    3365                 3370                 3375             


Glu Lys  Phe Trp Ile Pro Tyr  Ile His Asn Leu Lys  Val Pro Ile 
    3380                 3385                 3390             


Pro Ile  Thr Asn Gly Leu Asp  Pro Leu Ser Leu Leu  Thr Asp Asp 
    3395                 3400                 3405             


Ala Asp  Val Ala Thr Trp Asn  Asn Gln Gly Leu Pro  Ser Asp Arg 
    3410                 3415                 3420             


Met Ser  Thr Glu Asn Ala Thr  Ile Leu Gly Asn Thr  Glu Arg Trp 
    3425                 3430                 3435             


Pro Leu  Ile Val Asp Ala Gln  Leu Gln Gly Ile Lys  Trp Ile Lys 
    3440                 3445                 3450             


Asn Lys  Tyr Arg Ser Glu Leu  Lys Ala Ile Arg Leu  Gly Gln Lys 
    3455                 3460                 3465             


Ser Tyr  Leu Asp Val Ile Glu  Gln Ala Ile Ser Glu  Gly Asp Thr 
    3470                 3475                 3480             


Leu Leu  Ile Glu Asn Ile Gly  Glu Thr Val Asp Pro  Val Leu Asp 
    3485                 3490                 3495             


Pro Leu  Leu Gly Arg Asn Thr  Ile Lys Lys Gly Lys  Tyr Ile Lys 
    3500                 3505                 3510             


Ile Gly  Asp Lys Glu Val Glu  Tyr His Pro Lys Phe  Arg Leu Ile 
    3515                 3520                 3525             


Leu His  Thr Lys Tyr Phe Asn  Pro His Tyr Lys Pro  Glu Met Gln 
    3530                 3535                 3540             


Ala Gln  Cys Thr Leu Ile Asn  Phe Leu Val Thr Arg  Asp Gly Leu 
    3545                 3550                 3555             


Glu Asp  Gln Leu Leu Ala Ala  Val Val Ala Lys Glu  Arg Pro Asp 
    3560                 3565                 3570             


Leu Glu  Gln Leu Lys Ala Asn  Leu Thr Lys Ser Gln  Asn Glu Phe 
    3575                 3580                 3585             


Lys Ile  Val Leu Lys Glu Leu  Glu Asp Ser Leu Leu  Ala Arg Leu 
    3590                 3595                 3600             


Ser Ala  Ala Ser Gly Asn Phe  Leu Gly Asp Thr Ala  Leu Val Glu 
    3605                 3610                 3615             


Asn Leu  Glu Thr Thr Lys His  Thr Ala Ser Glu Ile  Glu Glu Lys 
    3620                 3625                 3630             


Val Val  Glu Ala Lys Ile Thr  Glu Val Lys Ile Asn  Glu Ala Arg 
    3635                 3640                 3645             


Glu Asn  Tyr Arg Pro Ala Ala  Glu Arg Ala Ser Leu  Leu Tyr Phe 
    3650                 3655                 3660             


Ile Leu  Asn Asp Leu Asn Lys  Ile Asn Pro Val Tyr  Gln Phe Ser 
    3665                 3670                 3675             


Leu Lys  Ala Phe Asn Val Val  Phe Glu Lys Ala Ile  Gln Arg Thr 
    3680                 3685                 3690             


Thr Pro  Ala Asn Glu Val Lys  Gln Arg Val Ile Asn  Leu Thr Asp 
    3695                 3700                 3705             


Glu Ile  Thr Tyr Ser Val Tyr  Met Tyr Thr Ala Arg  Gly Leu Phe 
    3710                 3715                 3720             


Glu Arg  Asp Lys Leu Ile Phe  Leu Ala Gln Val Thr  Phe Gln Val 
    3725                 3730                 3735             


Leu Ser  Met Lys Lys Glu Leu  Asn Pro Val Glu Leu  Asp Phe Leu 
    3740                 3745                 3750             


Leu Arg  Phe Pro Phe Lys Ala  Gly Val Val Ser Pro  Val Asp Phe 
    3755                 3760                 3765             


Leu Gln  His Gln Gly Trp Gly  Gly Ile Lys Ala Leu  Ser Glu Met 
    3770                 3775                 3780             


Asp Glu  Phe Lys Asn Leu Asp  Ser Asp Ile Glu Gly  Ser Ala Lys 
    3785                 3790                 3795             


Arg Trp  Lys Lys Leu Val Glu  Ser Glu Ala Pro Glu  Lys Glu Ile 
    3800                 3805                 3810             


Phe Pro  Lys Glu Trp Lys Asn  Lys Thr Ala Leu Gln  Lys Leu Cys 
    3815                 3820                 3825             


Met Val  Arg Cys Leu Arg Pro  Asp Arg Met Thr Tyr  Ala Ile Lys 
    3830                 3835                 3840             


Asn Phe  Val Glu Glu Lys Met  Gly Ser Lys Phe Val  Glu Gly Arg 
    3845                 3850                 3855             


Ser Val  Glu Phe Ser Lys Ser  Tyr Glu Glu Ser Ser  Pro Ser Thr 
    3860                 3865                 3870             


Ser Ile  Phe Phe Ile Leu Ser  Pro Gly Val Asp Pro  Leu Lys Asp 
    3875                 3880                 3885             


Val Glu  Ala Leu Gly Lys Lys  Leu Gly Phe Thr Ile  Asp Asn Gly 
    3890                 3895                 3900             


Lys Leu  His Asn Val Ser Leu  Gly Gln Gly Gln Glu  Val Val Ala 
    3905                 3910                 3915             


Glu Asn  Ala Leu Asp Val Ala  Ala Glu Lys Gly His  Trp Val Ile 
    3920                 3925                 3930             


Leu Gln  Asn Ile His Leu Val  Ala Arg Trp Leu Gly  Thr Leu Asp 
    3935                 3940                 3945             


Lys Lys  Leu Glu His Tyr Ser  Thr Gly Ser His Glu  Asp Tyr Arg 
    3950                 3955                 3960             


Val Phe  Ile Ser Ala Glu Pro  Ala Pro Ser Pro Glu  Thr His Ile 
    3965                 3970                 3975             


Ile Pro  Gln Gly Ile Leu Glu  Asn Ala Ile Lys Ile  Thr Asn Glu 
    3980                 3985                 3990             


Pro Pro  Thr Gly Met His Ala  Asn Leu His Lys Ala  Leu Asp Leu 
    3995                 4000                 4005             


Phe Thr  Gln Asp Thr Leu Glu  Met Cys Thr Lys Glu  Met Glu Phe 
    4010                 4015                 4020             


Lys Cys  Met Leu Phe Ala Leu  Cys Tyr Phe His Ala  Val Val Ala 
    4025                 4030                 4035             


Glu Arg  Arg Lys Phe Gly Ala  Gln Gly Trp Asn Arg  Ser Tyr Pro 
    4040                 4045                 4050             


Phe Asn  Asn Gly Asp Leu Thr  Ile Ser Ile Asn Val  Leu Tyr Asn 
    4055                 4060                 4065             


Tyr Leu  Glu Ala Asn Pro Lys  Val Pro Trp Asp Asp  Leu Arg Tyr 
    4070                 4075                 4080             


Leu Phe  Gly Glu Ile Met Tyr  Gly Gly His Ile Thr  Asp Asp Trp 
    4085                 4090                 4095             


Asp Arg  Arg Leu Cys Arg Thr  Tyr Leu Ala Glu Tyr  Ile Arg Thr 
    4100                 4105                 4110             


Glu Met  Leu Glu Gly Asp Val  Leu Leu Ala Pro Gly  Phe Gln Ile 
    4115                 4120                 4125             


Pro Pro  Asn Leu Asp Tyr Lys  Gly Tyr His Glu Tyr  Ile Asp Glu 
    4130                 4135                 4140             


Asn Leu  Pro Pro Glu Ser Pro  Tyr Leu Tyr Gly Leu  His Pro Asn 
    4145                 4150                 4155             


Ala Glu  Ile Gly Phe Leu Thr  Val Thr Ser Glu Lys  Leu Phe Arg 
    4160                 4165                 4170             


Thr Val  Leu Glu Met Gln Pro  Lys Glu Thr Asp Ser  Gly Ala Gly 
    4175                 4180                 4185             


Thr Gly  Val Ser Arg Glu Glu  Lys Val Lys Ala Val  Leu Asp Asp 
    4190                 4195                 4200             


Ile Leu  Glu Lys Ile Pro Glu  Thr Phe Asn Met Ala  Glu Ile Met 
    4205                 4210                 4215             


Ala Lys  Ala Ala Glu Lys Thr  Pro Tyr Val Val Val  Ala Phe Gln 
    4220                 4225                 4230             


Glu Cys  Glu Arg Met Asn Ile  Leu Thr Asn Glu Met  Arg Arg Ser 
    4235                 4240                 4245             


Leu Lys  Glu Leu Asn Leu Gly  Leu Lys Gly Glu Leu  Thr Ile Thr 
    4250                 4255                 4260             


Thr Asp  Val Glu Asp Leu Ser  Thr Ala Leu Phe Tyr  Asp Thr Val 
    4265                 4270                 4275             


Pro Asp  Thr Trp Val Ala Arg  Ala Tyr Pro Ser Met  Met Gly Leu 
    4280                 4285                 4290             


Ala Ala  Trp Tyr Ala Asp Leu  Leu Leu Arg Ile Arg  Glu Leu Glu 
    4295                 4300                 4305             


Ala Trp  Thr Thr Asp Phe Ala  Leu Pro Thr Thr Val  Trp Leu Ala 
    4310                 4315                 4320             


Gly Phe  Phe Asn Pro Gln Ser  Phe Leu Thr Ala Ile  Met Gln Ser 
    4325                 4330                 4335             


Met Ala  Arg Lys Asn Glu Trp  Pro Leu Asp Lys Met  Cys Leu Ser 
    4340                 4345                 4350             


Val Glu  Val Thr Lys Lys Asn  Arg Glu Asp Met Thr  Ala Pro Pro 
    4355                 4360                 4365             


Arg Glu  Gly Ser Tyr Val Tyr  Gly Leu Phe Met Glu  Gly Ala Arg 
    4370                 4375                 4380             


Trp Asp  Thr Gln Thr Gly Val  Ile Ala Glu Ala Arg  Leu Lys Glu 
    4385                 4390                 4395             


Leu Thr  Pro Ala Met Pro Val  Ile Phe Ile Lys Ala  Ile Pro Val 
    4400                 4405                 4410             


Asp Arg  Met Glu Thr Lys Asn  Ile Tyr Glu Cys Pro  Val Tyr Lys 
    4415                 4420                 4425             


Thr Arg  Ile Arg Gly Pro Thr  Tyr Val Trp Thr Phe  Asn Leu Lys 
    4430                 4435                 4440             


Thr Lys  Glu Lys Ala Ala Lys  Trp Ile Leu Ala Ala  Val Ala Leu 
    4445                 4450                 4455             


Leu Leu  Gln Val 
    4460         


<210>  3141
<211>  4265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH1__Homo_sapiens__NP_056327

<400>  3141

Met Glu Gln Pro Asn Ser Lys Gly Tyr Ser Leu Gly Arg Thr Pro Gln 
1               5                   10                  15      


Gly Pro Glu Cys Ser Ser Ala Pro Ala Val Gln Val Gly Thr His Arg 
            20                  25                  30          


Gly Leu Glu Tyr Asn Pro Gly Lys Ile Leu Pro Gly Ser Asp Tyr Gly 
        35                  40                  45              


Leu Gly Asn Pro Pro Ala Leu Asp Pro Lys Leu Pro His Leu Pro Leu 
    50                  55                  60                  


Pro Pro Ala Pro Pro Thr Leu Ser Asp Leu Gly Gln Pro Arg Lys Ser 
65                  70                  75                  80  


Pro Leu Thr Gly Thr Asp Lys Lys Tyr Pro Leu Met Lys Gln Arg Gly 
                85                  90                  95      


Phe Tyr Ser Asp Ile Leu Ser Pro Gly Thr Leu Asp Gln Leu Gly Glu 
            100                 105                 110         


Val Cys Arg Gly Pro Arg Met Ser Gln Asn Leu Leu Arg Gln Ala Asp 
        115                 120                 125             


Leu Asp Lys Phe Thr Pro Arg Val Gly Ser Phe Glu Val Pro Glu Asp 
    130                 135                 140                 


Phe Gln Glu Arg Met Glu Gln Gln Cys Ile Gly Ser Thr Thr Arg Leu 
145                 150                 155                 160 


Leu Ala Gln Thr Asp Phe Pro Leu Gln Ala Tyr Glu Pro Lys Met Gln 
                165                 170                 175     


Val Pro Phe Gln Val Leu Pro Gly Gln His Pro Arg Lys Ile Glu Ile 
            180                 185                 190         


Glu Arg Arg Lys Gln Gln Tyr Leu Ser Leu Asp Ile Glu Gln Leu Leu 
        195                 200                 205             


Phe Ser Gln Gly Ile Asp Ser Asn Lys Leu Met Pro Arg His Leu Asp 
    210                 215                 220                 


His Gln His Pro Gln Thr Ile Glu Gln Gly His Asp Pro Ile Phe Pro 
225                 230                 235                 240 


Ile Tyr Leu Pro Leu Lys Val Phe Asp Asn Glu Asp Phe Asp Cys Arg 
                245                 250                 255     


Thr Pro Arg Glu Trp Ile Asn Met Gly Leu Glu Pro Gly Ser Leu Asp 
            260                 265                 270         


Arg Lys Pro Val Pro Gly Lys Ala Leu Leu Pro Thr Asp Asp Phe Leu 
        275                 280                 285             


Gly His Glu Asp Pro Lys Ser Gln Lys Leu Lys Tyr Lys Trp Cys Glu 
    290                 295                 300                 


Val Gly Val Leu Asp Tyr Asp Glu Glu Lys Lys Leu Tyr Leu Val His 
305                 310                 315                 320 


Lys Thr Asp Glu Lys Gly Leu Val Arg Asp Glu Met Gly Arg Pro Ile 
                325                 330                 335     


Leu Asn Ala Gly Val Thr Thr Glu Gly Arg Pro Pro Leu Gln Val Cys 
            340                 345                 350         


Gln Tyr Trp Val Pro Arg Ile Gln Leu Leu Phe Cys Ala Glu Asp Pro 
        355                 360                 365             


Cys Met Phe Ala Gln Arg Val Val Gln Ala Asn Ala Leu Arg Lys Asn 
    370                 375                 380                 


Thr Glu Ala Leu Leu Leu Tyr Asn Leu Tyr Val Asp Cys Met Pro Ser 
385                 390                 395                 400 


Asp Gly Gln His Val Ile Ser Glu Gln Ser Leu Ser Lys Ile Lys Gln 
                405                 410                 415     


Trp Ala Leu Ser Thr Pro Arg Met Arg Lys Gly Pro Ser Val Leu Glu 
            420                 425                 430         


His Leu Ser Ser Leu Ala Arg Glu Val Ser Leu Asp Tyr Glu Arg Ser 
        435                 440                 445             


Met Asn Lys Ile Asn Phe Asp His Val Val Ser Ser Lys Pro Glu Thr 
    450                 455                 460                 


Phe Ser Tyr Val Thr Leu Pro Lys Lys Glu Glu Glu Gln Val Pro Glu 
465                 470                 475                 480 


Arg Gly Leu Val Ser Val Pro Lys Tyr His Phe Trp Glu Gln Lys Glu 
                485                 490                 495     


Asp Phe Thr Phe Val Ser Leu Leu Thr Arg Pro Glu Val Ile Thr Ala 
            500                 505                 510         


Leu Ser Lys Val Arg Ala Glu Cys Asn Lys Val Thr Ala Met Ser Leu 
        515                 520                 525             


Phe His Ser Ser Leu Ser Lys Tyr Ser His Leu Glu Glu Phe Glu Gln 
    530                 535                 540                 


Ile Gln Ser Gln Thr Phe Ser Gln Val Gln Met Phe Leu Lys Asp Ser 
545                 550                 555                 560 


Trp Ile Ser Ser Leu Lys Val Ala Met Arg Ser Ser Leu Arg Asp Met 
                565                 570                 575     


Ser Lys Gly Trp Tyr Asn Leu Tyr Glu Thr Asn Trp Glu Val Tyr Leu 
            580                 585                 590         


Met Ser Lys Leu Arg Lys Leu Met Glu Leu Val Lys Tyr Met Leu Gln 
        595                 600                 605             


Asp Thr Leu Arg Phe Leu Val Gln Asp Ser Leu Ala Ser Phe Ser Gln 
    610                 615                 620                 


Phe Ile Ser Asp Thr Cys Cys Ser Val Leu Asn Cys Thr Asp Asp Met 
625                 630                 635                 640 


Val Trp Gly Asp Asp Leu Ile Asn Ser Pro Tyr Arg Pro Arg Lys Asn 
                645                 650                 655     


Pro Leu Phe Ile Met Asp Leu Val Leu Asp Ser Ser Gly Val His Tyr 
            660                 665                 670         


Ser Thr Pro Leu Glu Gln Phe Glu Ala Ser Leu Leu Asn Leu Phe Asp 
        675                 680                 685             


Lys Gly Ile Leu Ala Thr His Ala Val Pro Gln Leu Glu Lys Leu Val 
    690                 695                 700                 


Met Glu Asp Ile Phe Ile Ser Gly Asp Pro Leu Leu Glu Ser Val Gly 
705                 710                 715                 720 


Leu His Glu Pro Leu Val Glu Glu Leu Arg Ala Thr Ile Ala Ser Ala 
                725                 730                 735     


Val Ser Lys Ala Met Ile Pro Leu Gln Ala Tyr Ala Lys Glu Tyr Arg 
            740                 745                 750         


Lys Tyr Leu Glu Leu Asn Asn Asn Asp Ile Ala Ser Phe Leu Lys Thr 
        755                 760                 765             


Tyr Gln Thr Gln Gly Leu Leu Ala Gln Glu Val Arg Glu Val Val Leu 
    770                 775                 780                 


Thr His Leu Arg Glu Lys Glu Ile Leu Asp Ser Ser Leu Pro Ser Ser 
785                 790                 795                 800 


Ile Ile Ile Gly Pro Phe Tyr Ile Asn Thr Asp Asn Val Lys Gln Ser 
                805                 810                 815     


Leu Ser Lys Lys Arg Lys Ala Leu Ala Thr Ser Val Leu Asp Ile Leu 
            820                 825                 830         


Ala Lys Asn Leu His Lys Glu Val Asp Ser Ile Cys Glu Glu Phe Arg 
        835                 840                 845             


Ser Ile Ser Arg Lys Ile Tyr Glu Lys Pro Asn Ser Ile Glu Glu Leu 
    850                 855                 860                 


Ala Glu Leu Arg Glu Trp Met Lys Gly Ile Pro Glu Arg Leu Val Gly 
865                 870                 875                 880 


Leu Glu Glu Arg Ile Val Lys Val Met Asp Asp Tyr Gln Val Met Asp 
                885                 890                 895     


Glu Phe Leu Tyr Asn Leu Ser Ser Asp Asp Phe Asn Asp Lys Trp Ile 
            900                 905                 910         


Ala Ser Asn Trp Pro Ser Lys Ile Leu Gly Gln Ile Glu Leu Val Gln 
        915                 920                 925             


Gln Gln His Val Glu Asp Glu Glu Lys Phe Arg Lys Ile Gln Ile Met 
    930                 935                 940                 


Asp Gln Asn Asn Phe Gln Glu Lys Leu Glu Gly Leu Gln Leu Val Val 
945                 950                 955                 960 


Ala Gly Phe Ser Ile His Val Glu Ile Ser Arg Ala His Glu Ile Ala 
                965                 970                 975     


Asn Glu Val Arg Arg Val Lys Lys Gln Leu Lys Asp Cys Gln Gln Leu 
            980                 985                 990         


Ala Met Leu Tyr Asn Asn Arg Glu  Arg Ile Phe Ser Leu  Pro Ile Thr 
        995                 1000                 1005             


Asn Tyr  Asp Lys Leu Ser Arg  Met Val Lys Glu Phe  Gln Pro Tyr 
    1010                 1015                 1020             


Leu Asp  Leu Trp Thr Thr Ala  Ser Asp Trp Leu Arg  Trp Ser Glu 
    1025                 1030                 1035             


Ser Trp  Met Asn Asp Pro Leu  Ser Ala Ile Asp Ala  Glu Gln Leu 
    1040                 1045                 1050             


Glu Lys  Asn Val Val Glu Ala  Phe Lys Thr Met His  Lys Cys Val 
    1055                 1060                 1065             


Lys Gln  Phe Lys Asp Met Pro  Ala Cys Gln Glu Val  Ala Leu Asp 
    1070                 1075                 1080             


Ile Arg  Ala Arg Ile Glu Glu  Phe Lys Pro Tyr Ile  Pro Leu Ile 
    1085                 1090                 1095             


Gln Gly  Leu Arg Asn Pro Gly  Met Arg Ile Arg His  Trp Glu Thr 
    1100                 1105                 1110             


Leu Ser  Asn Gln Ile Asn Ile  Asn Val Arg Pro Lys  Ala Asn Leu 
    1115                 1120                 1125             


Thr Phe  Ala Arg Cys Leu Glu  Met Asn Leu Gln Asp  His Ile Glu 
    1130                 1135                 1140             


Ser Ile  Ser Lys Val Ala Glu  Val Ala Gly Lys Glu  Tyr Ala Ile 
    1145                 1150                 1155             


Glu Gln  Ala Leu Asp Lys Met  Glu Lys Glu Trp Ser  Thr Ile Leu 
    1160                 1165                 1170             


Phe Asn  Val Leu Pro Tyr Lys  Ala Thr Asp Thr Tyr  Ile Leu Lys 
    1175                 1180                 1185             


Ser Pro  Asp Glu Ala Ser Gln  Leu Leu Asp Asp His  Ile Val Met 
    1190                 1195                 1200             


Thr Gln  Asn Met Ser Phe Ser  Pro Tyr Lys Lys Pro  Phe Glu Gln 
    1205                 1210                 1215             


Arg Ile  Asn Ser Trp Glu Asn  Lys Leu Lys Leu Thr  Gln Glu Val 
    1220                 1225                 1230             


Leu Glu  Glu Trp Leu Asn Cys  Gln Arg Ser Trp Leu  Tyr Leu Glu 
    1235                 1240                 1245             


Pro Ile  Phe Ser Ser Glu Asp  Ile Asn Gln Gln Leu  Pro Val Glu 
    1250                 1255                 1260             


Ser Lys  Arg Tyr Gln Thr Met  Glu Arg Ile Trp Lys  Lys Ile Met 
    1265                 1270                 1275             


Lys Asn  Ala Tyr Glu Asn Arg  Glu Val Ile Asn Val  Cys Ser Asp 
    1280                 1285                 1290             


Leu Arg  Met Leu Asp Ser Leu  Arg Asp Cys Asn Lys  Ile Leu Asp 
    1295                 1300                 1305             


Leu Val  Gln Lys Gly Leu Ser  Glu Tyr Leu Glu Thr  Lys Arg Ser 
    1310                 1315                 1320             


Ala Phe  Pro Arg Phe Tyr Phe  Leu Ser Asp Asp Glu  Leu Leu Glu 
    1325                 1330                 1335             


Ile Leu  Ser Gln Thr Lys Asp  Pro Thr Ala Val Gln  Pro His Leu 
    1340                 1345                 1350             


Arg Lys  Cys Phe Glu Asn Ile  Ala Arg Leu Leu Phe  Gln Glu Asp 
    1355                 1360                 1365             


Leu Glu  Ile Thr His Met Tyr  Ser Ala Glu Gly Glu  Glu Val Gln 
    1370                 1375                 1380             


Leu Cys  Phe Ser Ile Tyr Pro  Ser Ser Asn Val Glu  Asp Trp Leu 
    1385                 1390                 1395             


Arg Glu  Val Glu Arg Ser Met  Lys Ala Ser Val His  Asp Ile Ile 
    1400                 1405                 1410             


Glu Lys  Ala Ile Arg Ala Tyr  Pro Thr Met Pro Arg  Thr Gln Trp 
    1415                 1420                 1425             


Val Leu  Asn Trp Pro Gly Gln  Val Thr Ile Ala Gly  Cys Gln Thr 
    1430                 1435                 1440             


Tyr Trp  Thr Met Glu Val Ala  Glu Ala Leu Glu Ala  Gly Asn Leu 
    1445                 1450                 1455             


Arg Ser  Gln Leu Phe Pro Gln  Leu Cys Gln Gln Leu  Ser Asp Leu 
    1460                 1465                 1470             


Val Ala  Leu Val Arg Gly Lys  Leu Ser Arg Met Gln  Arg Ala Val 
    1475                 1480                 1485             


Leu Ser  Ala Leu Ile Val Ile  Glu Val His Ala Lys  Asp Val Val 
    1490                 1495                 1500             


Ser Lys  Leu Ile Gln Glu Asn  Val Val Ser Val Asn  Asp Phe Gln 
    1505                 1510                 1515             


Trp Ile  Ser Gln Leu Arg Tyr  Tyr Trp Thr Asn Asn  Asp Leu Tyr 
    1520                 1525                 1530             


Ile Arg  Ala Val Asn Ala Glu  Phe Ile Tyr Gly Tyr  Glu Tyr Leu 
    1535                 1540                 1545             


Gly Asn  Ser Gly Arg Leu Val  Ile Thr Pro Leu Thr  Asp Arg Cys 
    1550                 1555                 1560             


Tyr Leu  Thr Leu Thr Gly Ala  Leu His Leu Lys Phe  Gly Gly Ala 
    1565                 1570                 1575             


Pro Ala  Gly Pro Ala Gly Thr  Gly Lys Thr Glu Thr  Thr Lys Asp 
    1580                 1585                 1590             


Leu Gly  Lys Ala Leu Ala Ile  Gln Thr Val Val Phe  Asn Cys Ser 
    1595                 1600                 1605             


Asp Gln  Leu Asp Phe Met Ala  Met Gly Lys Phe Phe  Lys Gly Leu 
    1610                 1615                 1620             


Ala Ser  Ala Gly Ala Trp Ala  Cys Phe Asp Glu Phe  Asn Arg Ile 
    1625                 1630                 1635             


Asp Ile  Glu Val Leu Ser Val  Val Ala Gln Gln Ile  Thr Thr Ile 
    1640                 1645                 1650             


Gln Lys  Ala Gln Gln Gln Arg  Val Glu Arg Phe Met  Phe Glu Gly 
    1655                 1660                 1665             


Val Glu  Ile Pro Leu Val Pro  Ser Cys Ala Val Phe  Ile Thr Met 
    1670                 1675                 1680             


Asn Pro  Gly Tyr Ala Gly Arg  Thr Glu Leu Pro Asp  Asn Leu Lys 
    1685                 1690                 1695             


Ala Leu  Phe Arg Pro Val Ala  Met Met Val Pro Asp  Tyr Ala Met 
    1700                 1705                 1710             


Ile Thr  Glu Ile Ser Leu Tyr  Ser Phe Gly Phe Asn  Glu Ala Ser 
    1715                 1720                 1725             


Val Leu  Ala Lys Lys Ile Thr  Thr Thr Phe Lys Leu  Ser Ser Glu 
    1730                 1735                 1740             


Gln Leu  Ser Ser Gln Asp His  Tyr Asp Phe Gly Met  Arg Ala Val 
    1745                 1750                 1755             


Lys Thr  Val Ile Ser Ala Ala  Gly Asn Leu Lys Arg  Glu Asn Pro 
    1760                 1765                 1770             


Ser Met  Asn Glu Glu Leu Ile  Cys Leu Arg Ala Ile  Arg Asp Val 
    1775                 1780                 1785             


Asn Val  Pro Lys Phe Leu Gln  Glu Asp Leu Lys Leu  Phe Ser Gly 
    1790                 1795                 1800             


Ile Val  Ser Asp Leu Phe Pro  Thr Ile Lys Glu Glu  Asp Thr Asp 
    1805                 1810                 1815             


Tyr Gly  Ile Leu Asp Glu Ala  Ile Arg Glu Ala Cys  Arg Asn Ser 
    1820                 1825                 1830             


Asn Leu  Lys Asp Val Glu Gly  Phe Leu Thr Lys Cys  Ile Gln Leu 
    1835                 1840                 1845             


Tyr Glu  Thr Thr Val Val Arg  His Gly Leu Met Leu  Val Gly Pro 
    1850                 1855                 1860             


Thr Gly  Ser Gly Lys Ser Thr  Cys Tyr Arg Val Leu  Ala Ala Ala 
    1865                 1870                 1875             


Met Thr  Ser Leu Lys Gly Gln  Pro Ser Ile Ser Gly  Gly Met Tyr 
    1880                 1885                 1890             


Glu Ala  Val Asn Tyr Tyr Val  Leu Asn Pro Lys Ser  Ile Thr Met 
    1895                 1900                 1905             


Gly Gln  Leu Tyr Gly Glu Phe  Asp Leu Leu Thr His  Glu Trp Thr 
    1910                 1915                 1920             


Asp Gly  Ile Phe Ser Ser Phe  Ile Arg Ala Gly Ala  Ile Thr Ser 
    1925                 1930                 1935             


Asp Thr  Asn Lys Lys Trp Tyr  Met Phe Asp Gly Pro  Val Asp Ala 
    1940                 1945                 1950             


Ile Trp  Ile Glu Asn Met Asn  Thr Val Leu Asp Asp  Asn Lys Lys 
    1955                 1960                 1965             


Leu Cys  Leu Ser Ser Gly Glu  Ile Ile Lys Leu Thr  Glu Ala Met 
    1970                 1975                 1980             


Thr Met  Met Phe Glu Val Gln  Asp Leu Ala Val Ala  Ser Pro Ala 
    1985                 1990                 1995             


Thr Val  Ser Arg Cys Gly Met  Val Tyr Leu Glu Pro  Ser Ile Leu 
    2000                 2005                 2010             


Gly Leu  Met Pro Phe Ile Glu  Cys Trp Leu Arg Lys  Leu Pro Pro 
    2015                 2020                 2025             


Leu Leu  Lys Pro Tyr Glu Glu  His Phe Lys Ala Leu  Phe Val Ser 
    2030                 2035                 2040             


Phe Leu  Glu Glu Ser Ile Ser  Phe Val Arg Ser Ser  Val Lys Glu 
    2045                 2050                 2055             


Val Ile  Ala Ser Thr Asn Cys  Asn Leu Thr Met Ser  Leu Leu Lys 
    2060                 2065                 2070             


Leu Leu  Asp Cys Phe Phe Lys  Pro Phe Leu Pro Arg  Glu Gly Leu 
    2075                 2080                 2085             


Lys Lys  Ile Pro Ser Glu Lys  Leu Ser Arg Ile Val  Glu Leu Ile 
    2090                 2095                 2100             


Glu Pro  Trp Phe Ile Phe Ser  Leu Ile Trp Ser Val  Gly Ala Thr 
    2105                 2110                 2115             


Gly Asp  Ser Ser Gly Arg Thr  Ser Phe Ser His Trp  Leu Arg Leu 
    2120                 2125                 2130             


Lys Met  Glu Asn Glu Gln Leu  Thr Leu Leu Phe Pro  Glu Glu Gly 
    2135                 2140                 2145             


Leu Val  Phe Asp Tyr Arg Leu  Glu Asp Ala Gly Ile  Ser Gly Thr 
    2150                 2155                 2160             


Asn Asp  Ser Glu Asp Glu Glu  Glu Glu Tyr Lys Gln  Val Ala Trp 
    2165                 2170                 2175             


Val Lys  Trp Met Asp Ser Ser  Ala Pro Phe Thr Met  Val Pro Asp 
    2180                 2185                 2190             


Thr Asn  Tyr Cys Asn Ile Ile  Val Pro Thr Met Asp  Thr Val Gln 
    2195                 2200                 2205             


Met Ser  His Leu Leu Asp Met  Leu Leu Thr Asn Lys  Lys Pro Val 
    2210                 2215                 2220             


Leu Cys  Ile Gly Pro Thr Gly  Thr Gly Lys Thr Leu  Thr Ile Ser 
    2225                 2230                 2235             


Asp Lys  Leu Leu Lys Asn Leu  Ala Leu Asp Tyr Ile  Ser His Phe 
    2240                 2245                 2250             


Leu Thr  Phe Ser Ala Arg Thr  Ser Ala Asn Gln Thr  Gln Asp Phe 
    2255                 2260                 2265             


Ile Asp  Ser Lys Leu Asp Lys  Arg Arg Lys Gly Val  Phe Gly Pro 
    2270                 2275                 2280             


Pro Leu  Gly Arg Asn Phe Ile  Phe Phe Ile Asp Asp  Leu Asn Met 
    2285                 2290                 2295             


Pro Ala  Leu Glu Thr Tyr Gly  Ala Gln Pro Pro Ile  Glu Leu Leu 
    2300                 2305                 2310             


Arg Gln  Trp Met Asp His Gly  Gly Trp Tyr Asp Arg  Lys Ile Ile 
    2315                 2320                 2325             


Gly Ala  Phe Lys Asn Leu Val  Asp Ile Asn Phe Val  Cys Ala Met 
    2330                 2335                 2340             


Gly Pro  Pro Gly Gly Gly Arg  Asn Thr Val Thr Pro  Arg Leu Met 
    2345                 2350                 2355             


Arg His  Phe Asn Tyr Leu Ser  Phe Ala Glu Met Asp  Glu Val Ser 
    2360                 2365                 2370             


Lys Lys  Arg Ile Phe Ser Thr  Ile Leu Gly Asn Trp  Leu Asp Gly 
    2375                 2380                 2385             


Leu Leu  Gly Glu Lys Ser Tyr  Arg Glu Arg Val Pro  Gly Ala Pro 
    2390                 2395                 2400             


His Ile  Ala His Phe Thr Glu  Pro Leu Val Glu Ala  Thr Ile Met 
    2405                 2410                 2415             


Val Tyr  Ala Thr Ile Thr Ser  Gln Leu Leu Pro Thr  Pro Ala Lys 
    2420                 2425                 2430             


Ser His  Tyr Thr Phe Asn Leu  Arg Asp Leu Ser Lys  Val Phe Gln 
    2435                 2440                 2445             


Gly Met  Leu Met Ala Asp Pro  Ala Lys Val Glu Asp  Gln Val Gln 
    2450                 2455                 2460             


Leu Leu  Arg Leu Trp Tyr His  Glu Asn Cys Arg Val  Phe Arg Asp 
    2465                 2470                 2475             


Arg Leu  Val Asn Glu Glu Asp  Arg Ser Trp Phe Asp  Gln Leu Leu 
    2480                 2485                 2490             


Lys Arg  Cys Met Glu Gln Trp  Glu Val Thr Phe Asn  Lys Val Cys 
    2495                 2500                 2505             


Pro Phe  Gln Pro Ile Leu Tyr  Gly Asp Phe Met Ser  Pro Gly Ser 
    2510                 2515                 2520             


Asp Val  Lys Ser Tyr Glu Leu  Ile Thr Ser Glu Ser  Lys Met Met 
    2525                 2530                 2535             


Gln Val  Ile Glu Glu Tyr Ile  Glu Asp Tyr Asn Gln  Ile Asn Thr 
    2540                 2545                 2550             


Ala Lys  Leu Lys Leu Val Leu  Phe Met Asp Ala Met  Ser His Ile 
    2555                 2560                 2565             


Cys Arg  Ile Ser Arg Thr Leu  Arg Gln Ala Leu Gly  Asn Ala Leu 
    2570                 2575                 2580             


Leu Leu  Gly Val Gly Gly Ser  Gly Arg Ser Ser Leu  Thr Arg Leu 
    2585                 2590                 2595             


Ala Ser  His Met Ala Glu Tyr  Glu Cys Phe Gln Ile  Glu Leu Ser 
    2600                 2605                 2610             


Lys Asn  Tyr Gly Met Ser Glu  Trp Arg Asp Asp Val  Lys Lys Val 
    2615                 2620                 2625             


Leu Leu  Lys Ala Gly Leu Gln  Asn Leu Pro Ile Thr  Phe Leu Phe 
    2630                 2635                 2640             


Ser Asp  Thr Gln Ile Lys Asn  Glu Ser Phe Leu Glu  Asp Ile Asn 
    2645                 2650                 2655             


Asn Val  Leu Asn Ser Gly Asp  Ile Pro Asn Leu Tyr  Thr Ala Asp 
    2660                 2665                 2670             


Glu Gln  Asp Gln Ile Val Ser  Thr Met Arg Pro Tyr  Ile Gln Glu 
    2675                 2680                 2685             


Gln Gly  Leu Gln Pro Thr Lys  Ala Asn Leu Met Ala  Ala Tyr Thr 
    2690                 2695                 2700             


Gly Arg  Val Arg Ser Asn Ile  His Met Val Leu Cys  Met Ser Pro 
    2705                 2710                 2715             


Ile Gly  Glu Val Phe Arg Ala  Arg Leu Arg Gln Phe  Pro Ser Leu 
    2720                 2725                 2730             


Val Asn  Cys Cys Thr Ile Asp  Trp Phe Asn Glu Trp  Pro Ala Glu 
    2735                 2740                 2745             


Ala Leu  Lys Ser Val Ala Thr  Val Phe Leu Asn Glu  Ile Pro Glu 
    2750                 2755                 2760             


Leu Glu  Ser Ser Gln Glu Glu  Ile Gln Gly Leu Ile  Gln Val Cys 
    2765                 2770                 2775             


Val Tyr  Ile His Gln Ser Val  Ser Lys Lys Cys Ile  Glu Tyr Leu 
    2780                 2785                 2790             


Ala Glu  Leu Thr Arg His Asn  Tyr Val Thr Pro Lys  Ser Tyr Leu 
    2795                 2800                 2805             


Glu Leu  Leu His Ile Phe Ser  Ile Leu Ile Gly Gln  Lys Lys Leu 
    2810                 2815                 2820             


Glu Leu  Lys Thr Ala Lys Asn  Arg Met Lys Ser Gly  Leu Asp Lys 
    2825                 2830                 2835             


Leu Leu  Arg Thr Ser Glu Asp  Val Ala Lys Met Gln  Glu Asp Leu 
    2840                 2845                 2850             


Glu Ser  Met His Pro Leu Leu  Glu Glu Ala Ala Lys  Asp Thr Met 
    2855                 2860                 2865             


Leu Thr  Met Glu Gln Ile Lys  Val Asp Thr Ala Ile  Ala Glu Glu 
    2870                 2875                 2880             


Thr Arg  Asn Ser Val Gln Thr  Glu Glu Ile Lys Ala  Asn Glu Lys 
    2885                 2890                 2895             


Ala Lys  Lys Ala Gln Ala Ile  Ala Asp Asp Ala Gln  Lys Asp Leu 
    2900                 2905                 2910             


Asp Glu  Ala Leu Pro Ala Leu  Asp Ala Ala Leu Ala  Ser Leu Arg 
    2915                 2920                 2925             


Asn Leu  Asn Lys Asn Asp Val  Thr Glu Val Arg Ala  Met Gln Arg 
    2930                 2935                 2940             


Pro Pro  Pro Gly Val Lys Leu  Val Ile Glu Ala Val  Cys Ile Met 
    2945                 2950                 2955             


Lys Gly  Ile Lys Pro Lys Lys  Val Pro Gly Glu Lys  Pro Gly Thr 
    2960                 2965                 2970             


Lys Val  Asp Asp Tyr Trp Glu  Pro Gly Lys Gly Leu  Leu Gln Asp 
    2975                 2980                 2985             


Pro Gly  His Phe Leu Glu Ser  Leu Phe Lys Phe Asp  Lys Asp Asn 
    2990                 2995                 3000             


Ile Gly  Asp Val Val Ile Lys  Ala Ile Gln Pro Tyr  Ile Asp Asn 
    3005                 3010                 3015             


Glu Glu  Phe Gln Pro Ala Thr  Ile Ala Lys Val Ser  Lys Ala Cys 
    3020                 3025                 3030             


Thr Ser  Ile Cys Gln Trp Val  Arg Ala Met His Lys  Tyr His Phe 
    3035                 3040                 3045             


Val Ala  Lys Ala Val Glu Pro  Lys Arg Gln Ala Leu  Leu Glu Ala 
    3050                 3055                 3060             


Gln Asp  Asp Leu Gly Val Thr  Gln Arg Ile Leu Asp  Glu Ala Lys 
    3065                 3070                 3075             


Gln Arg  Leu Arg Glu Val Glu  Asp Gly Ile Ala Thr  Met Gln Ala 
    3080                 3085                 3090             


Lys Tyr  Arg Glu Cys Ile Thr  Lys Lys Glu Glu Leu  Glu Leu Lys 
    3095                 3100                 3105             


Cys Glu  Gln Cys Glu Gln Arg  Leu Gly Arg Ala Gly  Lys Leu Ile 
    3110                 3115                 3120             


Asn Gly  Leu Ser Asp Glu Lys  Val Arg Trp Gln Glu  Thr Val Glu 
    3125                 3130                 3135             


Asn Leu  Gln Tyr Met Leu Asn  Asn Ile Ser Gly Asp  Val Leu Val 
    3140                 3145                 3150             


Ala Ala  Gly Phe Val Ala Tyr  Leu Gly Pro Phe Thr  Gly Gln Tyr 
    3155                 3160                 3165             


Arg Thr  Val Leu Tyr Asp Ser  Trp Val Lys Gln Leu  Arg Ser His 
    3170                 3175                 3180             


Asn Val  Pro His Thr Ser Glu  Pro Thr Leu Ile Gly  Thr Leu Gly 
    3185                 3190                 3195             


Asn Pro  Val Lys Ile Arg Ser  Trp Gln Ile Ala Gly  Leu Pro Asn 
    3200                 3205                 3210             


Asp Thr  Leu Ser Val Glu Asn  Gly Val Ile Asn Gln  Phe Ser Gln 
    3215                 3220                 3225             


Arg Trp  Thr His Phe Ile Asp  Pro Gln Ser Gln Ala  Asn Lys Trp 
    3230                 3235                 3240             


Ile Lys  Asn Met Glu Lys Asp  Asn Gly Leu Asp Val  Phe Lys Leu 
    3245                 3250                 3255             


Ser Asp  Arg Asp Phe Leu Arg  Ser Met Glu Asn Ala  Ile Arg Phe 
    3260                 3265                 3270             


Gly Lys  Pro Cys Leu Leu Glu  Asn Val Gly Glu Glu  Leu Asp Pro 
    3275                 3280                 3285             


Ala Leu  Glu Pro Val Leu Leu  Lys Gln Thr Tyr Lys  Gln Gln Gly 
    3290                 3295                 3300             


Asn Thr  Val Leu Lys Leu Gly  Asp Thr Val Ile Pro  Tyr His Glu 
    3305                 3310                 3315             


Asp Phe  Arg Met Tyr Ile Thr  Thr Lys Leu Pro Asn  Pro His Tyr 
    3320                 3325                 3330             


Thr Pro  Glu Ile Ser Thr Lys  Leu Thr Leu Ile Asn  Phe Thr Leu 
    3335                 3340                 3345             


Ser Pro  Ser Gly Leu Glu Asp  Gln Leu Leu Gly Gln  Val Val Ala 
    3350                 3355                 3360             


Glu Glu  Arg Pro Asp Leu Glu  Glu Ala Lys Asn Gln  Leu Ile Ile 
    3365                 3370                 3375             


Ser Asn  Ala Lys Met Arg Gln  Glu Leu Lys Asp Ile  Glu Asp Gln 
    3380                 3385                 3390             


Ile Leu  Tyr Arg Leu Ser Ser  Ser Glu Gly Asn Pro  Val Asp Asp 
    3395                 3400                 3405             


Met Glu  Leu Ile Lys Val Leu  Glu Ala Ser Lys Met  Lys Ala Ala 
    3410                 3415                 3420             


Glu Ile  Gln Ala Lys Val Arg  Ile Ala Glu Gln Thr  Glu Lys Asp 
    3425                 3430                 3435             


Ile Asp  Leu Thr Arg Met Glu  Tyr Ile Pro Val Ala  Ile Arg Thr 
    3440                 3445                 3450             


Gln Ile  Leu Phe Phe Cys Val  Ser Asp Leu Ala Asn  Val Asp Pro 
    3455                 3460                 3465             


Met Tyr  Gln Tyr Ser Leu Glu  Trp Phe Leu Asn Ile  Phe Leu Ser 
    3470                 3475                 3480             


Gly Ile  Ala Asn Ser Glu Arg  Ala Asp Asn Leu Lys  Lys Arg Ile 
    3485                 3490                 3495             


Ser Asn  Ile Asn Arg Tyr Leu  Thr Tyr Ser Leu Tyr  Ser Asn Val 
    3500                 3505                 3510             


Cys Arg  Ser Leu Phe Glu Lys  His Lys Leu Met Phe  Ala Phe Leu 
    3515                 3520                 3525             


Leu Cys  Val Arg Ile Met Met  Asn Glu Gly Lys Ile  Asn Gln Ser 
    3530                 3535                 3540             


Glu Trp  Arg Tyr Leu Leu Ser  Gly Gly Ser Ile Ser  Ile Met Thr 
    3545                 3550                 3555             


Glu Asn  Pro Ala Pro Asp Trp  Leu Ser Asp Arg Ala  Trp Arg Asp 
    3560                 3565                 3570             


Ile Leu  Ala Leu Ser Asn Leu  Pro Thr Phe Ser Ser  Phe Ser Ser 
    3575                 3580                 3585             


Asp Phe  Val Lys His Leu Ser  Glu Phe Arg Val Ile  Phe Asp Ser 
    3590                 3595                 3600             


Leu Glu  Pro His Arg Glu Pro  Leu Pro Gly Ile Trp  Asp Gln Tyr 
    3605                 3610                 3615             


Leu Asp  Gln Phe Gln Lys Leu  Leu Val Leu Arg Cys  Leu Arg Gly 
    3620                 3625                 3630             


Asp Lys  Val Thr Asn Ala Met  Gln Asp Phe Val Ala  Thr Asn Leu 
    3635                 3640                 3645             


Glu Pro  Arg Phe Ile Glu Pro  Gln Thr Ala Asn Leu  Ser Val Val 
    3650                 3655                 3660             


Phe Lys  Asp Ser Asn Ser Thr  Thr Pro Leu Ile Phe  Val Leu Ser 
    3665                 3670                 3675             


Pro Gly  Thr Asp Pro Ala Ala  Asp Leu Tyr Lys Phe  Ala Glu Glu 
    3680                 3685                 3690             


Met Lys  Phe Ser Lys Lys Leu  Ser Ala Ile Ser Leu  Gly Gln Gly 
    3695                 3700                 3705             


Gln Gly  Pro Arg Ala Glu Ala  Met Met Arg Ser Ser  Ile Glu Arg 
    3710                 3715                 3720             


Gly Lys  Trp Val Phe Phe Gln  Asn Cys His Leu Ala  Pro Ser Trp 
    3725                 3730                 3735             


Met Pro  Ala Leu Glu Arg Leu  Ile Glu His Ile Asn  Pro Asp Lys 
    3740                 3745                 3750             


Val His  Arg Asp Phe Arg Leu  Trp Leu Thr Ser Leu  Pro Ser Asn 
    3755                 3760                 3765             


Lys Phe  Pro Val Ser Ile Leu  Gln Asn Gly Ser Lys  Met Thr Ile 
    3770                 3775                 3780             


Glu Pro  Pro Arg Gly Val Arg  Ala Asn Leu Leu Lys  Ser Tyr Ser 
    3785                 3790                 3795             


Ser Leu  Gly Glu Asp Phe Leu  Asn Ser Cys His Lys  Val Met Glu 
    3800                 3805                 3810             


Phe Lys  Ser Leu Leu Leu Ser  Leu Cys Leu Phe His  Gly Asn Ala 
    3815                 3820                 3825             


Leu Glu  Arg Arg Lys Phe Gly  Pro Leu Gly Phe Asn  Ile Pro Tyr 
    3830                 3835                 3840             


Glu Phe  Thr Asp Gly Asp Leu  Arg Ile Cys Ile Ser  Gln Leu Lys 
    3845                 3850                 3855             


Met Phe  Leu Asp Glu Tyr Asp  Asp Ile Pro Tyr Lys  Val Leu Lys 
    3860                 3865                 3870             


Tyr Thr  Ala Gly Glu Ile Asn  Tyr Gly Gly Arg Val  Thr Asp Asp 
    3875                 3880                 3885             


Trp Asp  Arg Arg Cys Ile Met  Asn Ile Leu Glu Asp  Phe Tyr Asn 
    3890                 3895                 3900             


Pro Asp  Val Leu Ser Pro Glu  His Ser Tyr Ser Ala  Ser Gly Ile 
    3905                 3910                 3915             


Tyr His  Gln Ile Pro Pro Thr  Tyr Asp Leu His Gly  Tyr Leu Ser 
    3920                 3925                 3930             


Tyr Ile  Lys Ser Leu Pro Leu  Asn Asp Met Pro Glu  Ile Phe Gly 
    3935                 3940                 3945             


Leu His  Asp Asn Ala Asn Ile  Thr Phe Ala Gln Asn  Glu Thr Phe 
    3950                 3955                 3960             


Ala Leu  Leu Gly Thr Ile Ile  Gln Leu Gln Pro Lys  Ser Ser Ser 
    3965                 3970                 3975             


Ala Gly  Ser Gln Gly Arg Glu  Glu Ile Val Glu Asp  Val Thr Gln 
    3980                 3985                 3990             


Asn Ile  Leu Leu Lys Val Pro  Glu Pro Ile Asn Leu  Gln Trp Val 
    3995                 4000                 4005             


Met Ala  Lys Tyr Pro Val Leu  Tyr Glu Glu Ser Met  Asn Thr Val 
    4010                 4015                 4020             


Leu Val  Gln Glu Val Ile Arg  Tyr Asn Arg Leu Leu  Gln Val Ile 
    4025                 4030                 4035             


Thr Gln  Thr Leu Gln Asp Leu  Leu Lys Ala Leu Lys  Gly Leu Val 
    4040                 4045                 4050             


Val Met  Ser Ser Gln Leu Glu  Leu Met Ala Ala Ser  Leu Tyr Asn 
    4055                 4060                 4065             


Asn Thr  Val Pro Glu Leu Trp  Ser Ala Lys Ala Tyr  Pro Ser Leu 
    4070                 4075                 4080             


Lys Pro  Leu Ser Ser Trp Val  Met Asp Leu Leu Gln  Arg Leu Asp 
    4085                 4090                 4095             


Phe Leu  Gln Ala Trp Ile Gln  Asp Gly Ile Pro Ala  Val Phe Trp 
    4100                 4105                 4110             


Ile Ser  Gly Phe Phe Phe Pro  Gln Ala Phe Leu Thr  Gly Thr Leu 
    4115                 4120                 4125             


Gln Asn  Phe Ala Arg Lys Phe  Val Ile Ser Ile Asp  Thr Ile Ser 
    4130                 4135                 4140             


Phe Asp  Phe Lys Val Met Phe  Glu Ala Pro Ser Glu  Leu Thr Gln 
    4145                 4150                 4155             


Arg Pro  Gln Val Gly Cys Tyr  Ile His Gly Leu Phe  Leu Glu Gly 
    4160                 4165                 4170             


Ala Arg  Trp Asp Pro Glu Ala  Phe Gln Leu Ala Glu  Ser Gln Pro 
    4175                 4180                 4185             


Lys Glu  Leu Tyr Thr Glu Met  Ala Val Ile Trp Leu  Leu Pro Thr 
    4190                 4195                 4200             


Pro Asn  Arg Lys Ala Gln Asp  Gln Asp Phe Tyr Leu  Cys Pro Ile 
    4205                 4210                 4215             


Tyr Lys  Thr Leu Thr Arg Ala  Gly Thr Leu Ser Thr  Thr Gly His 
    4220                 4225                 4230             


Ser Thr  Asn Tyr Val Ile Ala  Val Glu Ile Pro Thr  His Gln Pro 
    4235                 4240                 4245             


Gln Arg  His Trp Ile Lys Arg  Gly Val Ala Leu Ile  Cys Ala Leu 
    4250                 4255                 4260             


Asp Tyr  
    4265 


<210>  3142
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH2__Homo_sapiens__NP_001290199

<400>  3142

Met Ser Ser Lys Ala Glu Lys Lys Gln Arg Leu Ser Gly Arg Gly Ser 
1               5                   10                  15      


Ser Gln Ala Ser Trp Ser Gly Arg Ala Thr Arg Ala Ala Val Ala Thr 
            20                  25                  30          


Gln Glu Gln Gly Asn Ala Pro Ala Val Ser Glu Pro Glu Leu Gln Ala 
        35                  40                  45              


Glu Leu Pro Lys Glu Glu Pro Glu Pro Arg Leu Glu Gly Pro Gln Ala 
    50                  55                  60                  


Gln Ser Glu Glu Ser Val Glu Pro Glu Ala Asp Val Lys Pro Leu Phe 
65                  70                  75                  80  


Leu Ser Arg Ala Ala Leu Thr Gly Leu Ala Asp Ala Val Trp Thr Gln 
                85                  90                  95      


Glu His Asp Ala Ile Leu Glu His Phe Ala Gln Asp Pro Thr Glu Ser 
            100                 105                 110         


Ile Leu Thr Ile Phe Ile Asp Pro Cys Phe Gly Leu Lys Leu Glu Leu 
        115                 120                 125             


Gly Met Pro Val Gln Thr Gln Asn Gln Leu Val Tyr Phe Ile Arg Gln 
    130                 135                 140                 


Ala Pro Val Pro Ile Thr Trp Glu Asn Phe Glu Ala Thr Val Gln Phe 
145                 150                 155                 160 


Gly Thr Val Arg Gly Pro Tyr Ile Pro Ala Leu Leu Arg Leu Leu Gly 
                165                 170                 175     


Gly Val Phe Ala Pro Gln Ile Phe Ala Asn Thr Gly Trp Pro Glu Ser 
            180                 185                 190         


Ile Arg Asn His Phe Ala Ser His Leu His Lys Phe Leu Ala Cys Leu 
        195                 200                 205             


Thr Asp Thr Arg Tyr Lys Leu Glu Gly His Thr Val Leu Tyr Ile Pro 
    210                 215                 220                 


Ala Glu Ala Met Asn Met Lys Pro Glu Met Val Ile Lys Asp Lys Glu 
225                 230                 235                 240 


Leu Val Gln Arg Leu Glu Thr Ser Met Ile His Trp Thr Arg Gln Ile 
                245                 250                 255     


Lys Glu Met Leu Ser Ala Gln Glu Thr Val Glu Thr Gly Glu Asn Leu 
            260                 265                 270         


Gly Pro Leu Glu Glu Ile Glu Phe Trp Arg Asn Arg Cys Met Asp Leu 
        275                 280                 285             


Ser Gly Ile Ser Lys Gln Leu Val Lys Lys Gly Val Lys His Val Glu 
    290                 295                 300                 


Ser Ile Leu His Leu Ala Lys Ser Ser Tyr Leu Ala Pro Phe Met Lys 
305                 310                 315                 320 


Leu Ala Gln Gln Ile Gln Asp Gly Ser Arg Gln Ala Gln Ser Asn Leu 
                325                 330                 335     


Thr Phe Leu Ser Ile Leu Lys Glu Pro Tyr Gln Glu Leu Ala Phe Met 
            340                 345                 350         


Lys Pro Lys Asp Ile Ser Ser Lys Leu Pro Lys Leu Ile Ser Leu Ile 
        355                 360                 365             


Arg Ile Ile Trp Val Asn Ser Pro His Tyr Asn Thr Arg Glu Arg Leu 
    370                 375                 380                 


Thr Ser Leu Phe Arg Lys Met Ser Asn Glu Ile Ile Arg Leu Cys Cys 
385                 390                 395                 400 


His Ala Ile Ser Leu Asp Arg Ile Phe Glu Gly Tyr Val Ser Ser Ser 
                405                 410                 415     


Lys Glu Asp Leu Gln Gly Cys Ile Leu Cys Cys His Ala Trp Lys Asp 
            420                 425                 430         


His Tyr Val Gln Ala Val Gln Met His Ile Gln Phe Ser Ser Arg Gly 
        435                 440                 445             


Trp Val Leu Asp Gln Thr Ser Ile Phe Ala Gln Val Asp Ala Phe Val 
    450                 455                 460                 


Gln Arg Cys Lys Asp Leu Ile Glu Val Cys Asp Cys Gln Tyr His Phe 
465                 470                 475                 480 


Ala Arg Trp Glu Asp Gly Lys Gln Gly Pro Leu Pro Cys Phe Phe Gly 
                485                 490                 495     


Ala Gln Gly Pro Gln Ile Thr Arg Asn Leu Leu Glu Ile Glu Asp Ile 
            500                 505                 510         


Phe His Lys Asn Leu His Thr Leu Arg Ala Val Arg Gly Gly Ile Leu 
        515                 520                 525             


Asp Val Lys Asn Thr Cys Trp His Glu Asp Tyr Asn Lys Phe Arg Ala 
    530                 535                 540                 


Gly Ile Lys Asp Leu Glu Val Met Thr Gln Asn Leu Ile Thr Ser Ala 
545                 550                 555                 560 


Phe Glu Leu Val Arg Asp Val Pro His Gly Val Leu Leu Leu Asp Thr 
                565                 570                 575     


Phe His Arg Leu Ala Ser Arg Glu Ala Ile Lys Arg Thr Tyr Asp Lys 
            580                 585                 590         


Lys Ala Val Asp Leu Tyr Met Leu Phe Asn Ser Glu Leu Ala Leu Val 
        595                 600                 605             


Asn Arg Glu Arg Asn Lys Lys Trp Pro Asp Leu Glu Pro Tyr Val Ala 
    610                 615                 620                 


Gln Tyr Ser Gly Lys Ala Arg Trp Val His Ile Leu Arg Arg Arg Ile 
625                 630                 635                 640 


Asp Arg Val Met Thr Cys Leu Ala Gly Ala His Phe Leu Pro Arg Ile 
                645                 650                 655     


Gly Thr Gly Lys Glu Ser Val His Thr Tyr Gln Gln Met Val Gln Ala 
            660                 665                 670         


Ile Asp Glu Leu Val Arg Lys Thr Phe Gln Glu Trp Thr Ser Ser Leu 
        675                 680                 685             


Asp Lys Asp Cys Ile Arg Arg Leu Asp Thr Pro Leu Leu Arg Ile Ser 
    690                 695                 700                 


Gln Glu Lys Ala Gly Met Leu Asp Val Asn Phe Asp Lys Tyr Arg Ser 
705                 710                 715                 720 


His Leu Ala Pro Phe Pro Tyr Thr Pro Leu Leu Gln Leu Ser Gln Glu 
                725                 730                 735     


Phe His Ser His Leu Leu Thr Pro Leu Phe Ile Ile Leu Ser Leu Ser 
            740                 745                 750         


His Thr Ile Cys Leu Leu Ser Ser Phe Tyr Phe Phe Phe Ser Ser Phe 
        755                 760                 765             


Ile Phe Val Ser Pro His Leu Pro Pro Cys Tyr Gln His Phe Asn Phe 
    770                 775                 780                 


Thr Thr Tyr Leu Lys Thr Gln Gln Asn Lys Thr Met Ile Gly Gln Ala 
785                 790                 795                 800 


Arg Trp Leu Thr Pro Val Ile Pro Ala Leu Trp Glu Ala Glu Val Gly 
                805                 810                 815     


Ala Ser Leu Glu Pro Arg Ser Leu Arg Thr Ala Trp Ala Thr Trp Gln 
            820                 825                 830         


Asn Pro Val Ser Ala Lys Asn Thr Lys Ile Ser Trp Ala Trp Trp His 
        835                 840                 845             


Lys Pro Val Val Ser Ala Thr Trp Glu Gly Glu Val Gly Gly Ser Pro 
    850                 855                 860                 


Glu Pro Gly Arg Gln Arg Leu Gln 
865                 870         


<210>  3143
<211>  4116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH3__Homo_sapiens__NP_060009

<400>  3143

Met Gly Ala Thr Gly Arg Leu Glu Leu Thr Leu Ala Ala Pro Pro His 
1               5                   10                  15      


Pro Gly Pro Ala Phe Gln Arg Ser Lys Ala Arg Glu Thr Gln Gly Glu 
            20                  25                  30          


Glu Glu Gly Ser Glu Met Gln Ile Ala Lys Ser Asp Ser Ile His His 
        35                  40                  45              


Met Ser His Ser Gln Gly Gln Pro Glu Leu Pro Pro Leu Pro Ala Ser 
    50                  55                  60                  


Ala Asn Glu Glu Pro Ser Gly Leu Tyr Gln Thr Val Met Ser His Ser 
65                  70                  75                  80  


Phe Tyr Pro Pro Leu Met Gln Arg Thr Ser Trp Thr Leu Ala Ala Pro 
                85                  90                  95      


Phe Lys Glu Gln His His His Arg Gly Pro Ser Asp Ser Ile Ala Asn 
            100                 105                 110         


Asn Tyr Ser Leu Met Ala Gln Asp Leu Lys Leu Lys Asp Leu Leu Lys 
        115                 120                 125             


Val Tyr Gln Pro Ala Thr Ile Ser Val Pro Arg Asp Arg Thr Gly Gln 
    130                 135                 140                 


Gly Leu Pro Ser Ser Gly Asn Arg Ser Ser Ser Glu Pro Met Arg Lys 
145                 150                 155                 160 


Lys Thr Lys Phe Ser Ser Arg Asn Lys Glu Asp Ser Thr Arg Ile Lys 
                165                 170                 175     


Leu Ala Phe Lys Thr Ser Ile Phe Ser Pro Met Lys Lys Glu Val Lys 
            180                 185                 190         


Thr Ser Leu Thr Phe Pro Gly Ser Arg Pro Met Ser Pro Glu Gln Gln 
        195                 200                 205             


Leu Asp Val Met Leu Gln Gln Glu Met Glu Met Glu Ser Lys Glu Lys 
    210                 215                 220                 


Lys Pro Ser Glu Ser Asp Leu Glu Arg Tyr Tyr Tyr Tyr Leu Thr Asn 
225                 230                 235                 240 


Gly Ile Arg Lys Asp Met Ile Ala Pro Glu Glu Gly Glu Val Met Val 
                245                 250                 255     


Arg Ile Ser Lys Leu Ile Ser Asn Thr Leu Leu Thr Ser Pro Phe Leu 
            260                 265                 270         


Glu Pro Leu Met Val Val Leu Val Gln Glu Lys Glu Asn Asp Tyr Tyr 
        275                 280                 285             


Cys Ser Leu Met Lys Ser Ile Val Asp Tyr Ile Leu Met Asp Pro Met 
    290                 295                 300                 


Glu Arg Lys Arg Leu Phe Ile Glu Ser Ile Pro Arg Leu Phe Pro Gln 
305                 310                 315                 320 


Arg Val Ile Arg Ala Pro Val Pro Trp His Ser Val Tyr Arg Ser Ala 
                325                 330                 335     


Lys Lys Trp Asn Glu Glu His Leu His Thr Val Asn Pro Met Met Leu 
            340                 345                 350         


Arg Leu Lys Glu Leu Trp Phe Ala Glu Phe Arg Asp Leu Arg Phe Val 
        355                 360                 365             


Arg Thr Ala Glu Ile Leu Ala Gly Lys Leu Pro Leu Gln Pro Gln Glu 
    370                 375                 380                 


Phe Trp Asp Val Ile Gln Lys His Cys Leu Glu Ala His Gln Thr Leu 
385                 390                 395                 400 


Leu Asn Lys Trp Ile Pro Thr Cys Ala Gln Leu Phe Thr Ser Arg Lys 
                405                 410                 415     


Glu His Trp Ile His Phe Ala Pro Lys Ser Asn Tyr Asp Ser Ser Arg 
            420                 425                 430         


Asn Ile Glu Glu Tyr Phe Ala Ser Val Ala Ser Phe Met Ser Leu Gln 
        435                 440                 445             


Leu Arg Glu Leu Val Ile Lys Ser Leu Glu Asp Leu Val Ser Leu Phe 
    450                 455                 460                 


Met Ile His Lys Asp Gly Asn Asp Phe Lys Glu Pro Tyr Gln Glu Met 
465                 470                 475                 480 


Lys Phe Phe Ile Pro Gln Leu Ile Met Ile Lys Leu Glu Val Ser Glu 
                485                 490                 495     


Pro Ile Ile Val Phe Asn Pro Ser Phe Asp Gly Cys Trp Glu Leu Ile 
            500                 505                 510         


Arg Asp Ser Phe Leu Glu Ile Ile Lys Asn Ser Asn Gly Ile Pro Lys 
        515                 520                 525             


Leu Lys Tyr Ile Pro Leu Lys Phe Ser Phe Thr Ala Ala Ala Ala Asp 
    530                 535                 540                 


Arg Gln Cys Val Lys Ala Ala Glu Pro Gly Glu Pro Ser Met His Ala 
545                 550                 555                 560 


Ala Ala Thr Ala Met Ala Glu Leu Lys Gly Tyr Asn Leu Leu Leu Gly 
                565                 570                 575     


Thr Val Asn Ala Glu Glu Lys Leu Val Ser Asp Phe Leu Ile Gln Thr 
            580                 585                 590         


Phe Lys Val Phe Gln Lys Asn Gln Val Gly Pro Cys Lys Tyr Leu Asn 
        595                 600                 605             


Val Tyr Lys Lys Tyr Val Asp Leu Leu Asp Asn Thr Ala Glu Gln Asn 
    610                 615                 620                 


Ile Ala Ala Phe Leu Lys Glu Asn His Asp Ile Asp Asp Phe Val Thr 
625                 630                 635                 640 


Lys Ile Asn Ala Ile Lys Lys Arg Arg Asn Glu Ile Ala Ser Met Asn 
                645                 650                 655     


Ile Thr Val Pro Leu Ala Met Phe Cys Leu Asp Ala Thr Ala Leu Asn 
            660                 665                 670         


His Asp Leu Cys Glu Arg Ala Gln Asn Leu Lys Asp His Leu Ile Gln 
        675                 680                 685             


Phe Gln Val Asp Val Asn Arg Asp Thr Asn Thr Ser Ile Cys Asn Gln 
    690                 695                 700                 


Tyr Ser His Ile Ala Asp Lys Val Ser Glu Val Pro Ala Asn Thr Lys 
705                 710                 715                 720 


Glu Leu Val Ser Leu Ile Glu Phe Leu Lys Lys Ser Ser Ala Val Thr 
                725                 730                 735     


Val Phe Lys Leu Arg Arg Gln Leu Arg Asp Ala Ser Glu Arg Leu Glu 
            740                 745                 750         


Phe Leu Met Asp Tyr Ala Asp Leu Pro Tyr Gln Ile Glu Asp Ile Phe 
        755                 760                 765             


Asp Asn Ser Arg Asn Leu Leu Leu His Lys Arg Asp Gln Ala Glu Met 
    770                 775                 780                 


Asp Leu Ile Lys Arg Cys Ser Glu Phe Glu Leu Arg Leu Glu Gly Tyr 
785                 790                 795                 800 


His Arg Glu Leu Glu Ser Phe Arg Lys Arg Glu Val Met Thr Thr Glu 
                805                 810                 815     


Glu Met Lys His Asn Val Glu Lys Leu Asn Glu Leu Ser Lys Asn Leu 
            820                 825                 830         


Asn Arg Ala Phe Ala Glu Phe Glu Leu Ile Asn Lys Glu Glu Glu Leu 
        835                 840                 845             


Leu Glu Lys Glu Lys Ser Thr Tyr Pro Leu Leu Gln Ala Met Leu Lys 
    850                 855                 860                 


Asn Lys Val Pro Tyr Glu Gln Leu Trp Ser Thr Ala Tyr Glu Phe Ser 
865                 870                 875                 880 


Ile Lys Ser Glu Glu Trp Met Asn Gly Pro Leu Phe Leu Leu Asn Ala 
                885                 890                 895     


Glu Gln Ile Ala Glu Glu Ile Gly Asn Met Trp Arg Thr Thr Tyr Lys 
            900                 905                 910         


Leu Ile Lys Thr Leu Ser Asp Val Pro Ala Pro Arg Arg Leu Ala Glu 
        915                 920                 925             


Asn Val Lys Ile Lys Ile Asp Lys Phe Lys Gln Tyr Ile Pro Ile Leu 
    930                 935                 940                 


Ser Ile Ser Cys Asn Pro Gly Met Lys Asp Arg His Trp Gln Gln Ile 
945                 950                 955                 960 


Ser Glu Ile Val Gly Tyr Glu Ile Lys Pro Thr Glu Thr Thr Cys Leu 
                965                 970                 975     


Ser Asn Met Leu Glu Phe Gly Phe Gly Lys Phe Val Glu Lys Leu Glu 
            980                 985                 990         


Pro Ile Gly Ala Ala Ala Ser Lys  Glu Tyr Ser Leu Glu  Lys Asn Leu 
        995                 1000                 1005             


Asp Arg  Met Lys Leu Asp Trp  Val Asn Val Thr Phe  Ser Phe Val 
    1010                 1015                 1020             


Lys Tyr  Arg Asp Thr Asp Thr  Asn Ile Leu Cys Ala  Ile Asp Asp 
    1025                 1030                 1035             


Ile Gln  Met Leu Leu Asp Asp  His Val Ile Lys Thr  Gln Thr Met 
    1040                 1045                 1050             


Cys Gly  Ser Pro Phe Ile Lys  Pro Ile Glu Ala Glu  Cys Arg Lys 
    1055                 1060                 1065             


Trp Glu  Glu Lys Leu Ile Arg  Ile Gln Asp Asn Leu  Asp Ala Trp 
    1070                 1075                 1080             


Leu Lys  Cys Gln Ala Thr Trp  Leu Tyr Leu Glu Pro  Ile Phe Ser 
    1085                 1090                 1095             


Ser Glu  Asp Ile Ile Ala Gln  Met Pro Glu Glu Gly  Arg Lys Phe 
    1100                 1105                 1110             


Gly Ile  Val Asp Ser Tyr Trp  Lys Ser Leu Met Ser  Gln Ala Val 
    1115                 1120                 1125             


Lys Asp  Asn Arg Ile Leu Val  Ala Ala Asp Gln Pro  Arg Met Ala 
    1130                 1135                 1140             


Glu Lys  Leu Gln Glu Ala Asn  Phe Leu Leu Glu Asp  Ile Gln Lys 
    1145                 1150                 1155             


Gly Leu  Asn Asp Tyr Leu Glu  Lys Lys Arg Leu Phe  Phe Pro Arg 
    1160                 1165                 1170             


Phe Phe  Phe Leu Ser Asn Asp  Glu Leu Leu Glu Ile  Leu Ser Glu 
    1175                 1180                 1185             


Thr Lys  Asp Pro Leu Arg Val  Gln Pro His Leu Lys  Lys Cys Phe 
    1190                 1195                 1200             


Glu Gly  Ile Ala Lys Leu Glu  Phe Thr Asp Asn Leu  Glu Ile Val 
    1205                 1210                 1215             


Gly Met  Ile Ser Ser Glu Lys  Glu Thr Val Pro Phe  Ile Gln Lys 
    1220                 1225                 1230             


Ile Tyr  Pro Ala Asn Ala Lys  Gly Met Val Glu Lys  Trp Leu Gln 
    1235                 1240                 1245             


Gln Val  Glu Gln Met Met Leu  Ala Ser Met Arg Glu  Val Ile Gly 
    1250                 1255                 1260             


Leu Gly  Ile Glu Ala Tyr Val  Lys Val Pro Arg Asn  His Trp Val 
    1265                 1270                 1275             


Leu Gln  Trp Pro Gly Gln Val  Val Ile Cys Val Ser  Ser Ile Phe 
    1280                 1285                 1290             


Trp Thr  Gln Glu Val Ser Gln  Ala Leu Ala Glu Asn  Thr Leu Leu 
    1295                 1300                 1305             


Asp Phe  Leu Lys Lys Ser Asn  Asp Gln Ile Ala Gln  Ile Val Gln 
    1310                 1315                 1320             


Leu Val  Arg Gly Lys Leu Ser  Ser Gly Ala Arg Leu  Thr Leu Gly 
    1325                 1330                 1335             


Ala Leu  Thr Val Ile Asp Val  His Ala Arg Asp Val  Val Ala Lys 
    1340                 1345                 1350             


Leu Ser  Glu Asp Arg Val Ser  Asp Leu Asn Asp Phe  Gln Trp Ile 
    1355                 1360                 1365             


Ser Gln  Leu Arg Tyr Tyr Trp  Val Ala Lys Asp Val  Gln Val Gln 
    1370                 1375                 1380             


Ile Ile  Thr Thr Glu Ala Leu  Tyr Gly Tyr Glu Tyr  Leu Gly Asn 
    1385                 1390                 1395             


Ser Pro  Arg Leu Val Ile Thr  Pro Leu Thr Asp Arg  Cys Tyr Arg 
    1400                 1405                 1410             


Thr Leu  Met Gly Ala Leu Lys  Leu Asn Leu Gly Gly  Ala Pro Glu 
    1415                 1420                 1425             


Gly Pro  Ala Gly Thr Gly Lys  Thr Glu Thr Thr Lys  Asp Leu Ala 
    1430                 1435                 1440             


Lys Ala  Leu Ala Lys Gln Cys  Val Val Phe Asn Cys  Ser Asp Gly 
    1445                 1450                 1455             


Leu Asp  Tyr Lys Ala Met Gly  Lys Phe Phe Lys Gly  Leu Ala Gln 
    1460                 1465                 1470             


Ala Gly  Ala Trp Ala Cys Phe  Asp Glu Phe Asn Arg  Ile Glu Val 
    1475                 1480                 1485             


Glu Val  Leu Ser Val Val Ala  Gln Gln Ile Leu Ser  Ile Gln Gln 
    1490                 1495                 1500             


Ala Ile  Ile Arg Lys Leu Lys  Thr Phe Ile Phe Glu  Gly Thr Glu 
    1505                 1510                 1515             


Leu Ser  Leu Asn Pro Thr Cys  Ala Val Phe Ile Thr  Met Asn Pro 
    1520                 1525                 1530             


Gly Tyr  Ala Gly Arg Ala Glu  Leu Pro Asp Asn Leu  Lys Ala Leu 
    1535                 1540                 1545             


Phe Arg  Thr Val Ala Met Met  Val Pro Asp Tyr Ala  Leu Ile Gly 
    1550                 1555                 1560             


Glu Ile  Ser Leu Tyr Ser Met  Gly Phe Leu Asp Ser  Arg Ser Leu 
    1565                 1570                 1575             


Ala Gln  Lys Ile Val Ala Thr  Tyr Arg Leu Cys Ser  Glu Gln Leu 
    1580                 1585                 1590             


Ser Ser  Gln His His Tyr Asp  Tyr Gly Met Arg Ala  Val Lys Ser 
    1595                 1600                 1605             


Val Leu  Thr Ala Ala Gly Asn  Leu Lys Leu Lys Tyr  Pro Glu Glu 
    1610                 1615                 1620             


Asn Glu  Ser Val Leu Leu Leu  Arg Ala Leu Leu Asp  Val Asn Leu 
    1625                 1630                 1635             


Ala Lys  Phe Leu Ala Gln Asp  Val Pro Leu Phe Gln  Gly Ile Ile 
    1640                 1645                 1650             


Ser Asp  Leu Phe Pro Gly Val  Val Leu Pro Lys Pro  Asp Tyr Glu 
    1655                 1660                 1665             


Val Phe  Leu Lys Val Leu Asn  Asp Asn Ile Lys Lys  Met Lys Leu 
    1670                 1675                 1680             


Gln Pro  Val Pro Trp Phe Ile  Gly Lys Ile Ile Gln  Ile Tyr Glu 
    1685                 1690                 1695             


Met Met  Leu Val Arg His Gly  Tyr Met Ile Val Gly  Asp Pro Met 
    1700                 1705                 1710             


Gly Gly  Lys Thr Ser Ala Tyr  Lys Val Leu Ala Ala  Ala Leu Gly 
    1715                 1720                 1725             


Asp Leu  His Ala Ala Asn Gln  Met Glu Glu Phe Ala  Val Glu Tyr 
    1730                 1735                 1740             


Lys Ile  Ile Asn Pro Lys Ala  Ile Thr Met Gly Gln  Leu Tyr Gly 
    1745                 1750                 1755             


Cys Phe  Asp Gln Val Ser His  Glu Trp Met Asp Gly  Val Leu Ala 
    1760                 1765                 1770             


Asn Ala  Phe Arg Glu Gln Ala  Ser Ser Leu Ser Asp  Asp Arg Lys 
    1775                 1780                 1785             


Trp Ile  Ile Phe Asp Gly Pro  Val Asp Ala Ile Trp  Ile Glu Asn 
    1790                 1795                 1800             


Met Asn  Thr Val Leu Asp Asp  Asn Lys Lys Leu Cys  Leu Met Ser 
    1805                 1810                 1815             


Gly Glu  Ile Ile Gln Met Asn  Ser Lys Met Ser Leu  Ile Phe Glu 
    1820                 1825                 1830             


Pro Ala  Asp Leu Glu Gln Ala  Ser Pro Ala Thr Val  Ser Arg Cys 
    1835                 1840                 1845             


Gly Met  Ile Tyr Met Glu Pro  His Gln Leu Gly Trp  Lys Pro Leu 
    1850                 1855                 1860             


Lys Asp  Ser Tyr Met Asp Thr  Leu Pro Ser Ser Leu  Thr Lys Glu 
    1865                 1870                 1875             


His Lys  Glu Leu Val Asn Asp  Met Phe Met Trp Leu  Val Gln Pro 
    1880                 1885                 1890             


Cys Leu  Glu Phe Gly Arg Leu  His Cys Lys Phe Val  Val Gln Thr 
    1895                 1900                 1905             


Ser Pro  Ile His Leu Ala Phe  Ser Met Met Arg Leu  Tyr Ser Ser 
    1910                 1915                 1920             


Leu Leu  Asp Glu Ile Arg Ala  Val Glu Glu Glu Glu  Met Glu Leu 
    1925                 1930                 1935             


Gly Glu  Gly Leu Ser Ser Gln  Gln Ile Phe Leu Trp  Leu Gln Gly 
    1940                 1945                 1950             


Leu Phe  Leu Phe Ser Leu Val  Trp Thr Val Ala Gly  Thr Ile Asn 
    1955                 1960                 1965             


Ala Asp  Ser Arg Lys Lys Phe  Asp Val Phe Phe Arg  Asn Leu Ile 
    1970                 1975                 1980             


Met Gly  Met Asp Asp Asn His  Pro Arg Pro Lys Ser  Val Lys Leu 
    1985                 1990                 1995             


Thr Lys  Asn Asn Ile Phe Pro  Glu Arg Gly Ser Ile  Tyr Asp Phe 
    2000                 2005                 2010             


Tyr Phe  Ile Lys Gln Ala Ser  Gly His Trp Glu Thr  Trp Thr Gln 
    2015                 2020                 2025             


Tyr Ile  Thr Lys Glu Glu Glu  Lys Val Pro Ala Gly  Ala Lys Val 
    2030                 2035                 2040             


Ser Glu  Leu Ile Ile Pro Thr  Met Glu Thr Ala Arg  Gln Ser Phe 
    2045                 2050                 2055             


Phe Leu  Lys Thr Tyr Leu Asp  His Glu Ile Pro Met  Leu Phe Val 
    2060                 2065                 2070             


Gly Pro  Thr Gly Thr Gly Lys  Ser Ala Ile Thr Asn  Asn Phe Leu 
    2075                 2080                 2085             


Leu His  Leu Pro Lys Asn Thr  Tyr Leu Pro Asn Cys  Ile Asn Phe 
    2090                 2095                 2100             


Ser Ala  Arg Thr Ser Ala Asn  Gln Thr Gln Asp Ile  Ile Met Ser 
    2105                 2110                 2115             


Lys Leu  Asp Arg Arg Arg Lys  Gly Leu Phe Gly Pro  Pro Ile Gly 
    2120                 2125                 2130             


Lys Lys  Ala Val Val Phe Val  Asp Asp Leu Asn Met  Pro Ala Lys 
    2135                 2140                 2145             


Glu Val  Tyr Gly Ala Gln Pro  Pro Ile Glu Leu Leu  Arg Gln Trp 
    2150                 2155                 2160             


Ile Asp  His Gly Tyr Trp Phe  Asp Lys Lys Asp Thr  Thr Arg Leu 
    2165                 2170                 2175             


Asp Ile  Val Asp Met Leu Leu  Val Thr Ala Met Gly  Pro Pro Gly 
    2180                 2185                 2190             


Gly Gly  Arg Asn Asp Ile Thr  Gly Arg Phe Thr Arg  His Leu Asn 
    2195                 2200                 2205             


Ile Ile  Ser Ile Asn Ala Phe  Glu Asp Asp Ile Leu  Thr Lys Ile 
    2210                 2215                 2220             


Phe Ser  Ser Ile Val Asp Trp  His Phe Gly Lys Gly  Phe Asp Val 
    2225                 2230                 2235             


Met Phe  Leu Arg Tyr Gly Lys  Met Leu Val Gln Ala  Thr Lys Thr 
    2240                 2245                 2250             


Ile Tyr  Arg Asp Ala Val Glu  Asn Phe Leu Pro Thr  Pro Ser Lys 
    2255                 2260                 2265             


Ser His  Tyr Val Phe Asn Leu  Arg Asp Phe Ser Arg  Val Ile Gln 
    2270                 2275                 2280             


Gly Val  Leu Leu Cys Pro His  Thr His Leu Gln Asp  Val Glu Lys 
    2285                 2290                 2295             


Cys Ile  Arg Leu Trp Ile His  Glu Val Tyr Arg Val  Phe Tyr Asp 
    2300                 2305                 2310             


Arg Leu  Ile Asp Lys Glu Asp  Arg Gln Val Phe Phe  Asn Met Val 
    2315                 2320                 2325             


Lys Glu  Thr Thr Ser Asn Cys  Phe Lys Gln Thr Ile  Glu Lys Val 
    2330                 2335                 2340             


Leu Ile  His Leu Ser Pro Thr  Gly Lys Ile Val Asp  Asp Asn Ile 
    2345                 2350                 2355             


Arg Ser  Leu Phe Phe Gly Asp  Tyr Phe Lys Pro Glu  Ser Asp Gln 
    2360                 2365                 2370             


Lys Ile  Tyr Asp Glu Ile Thr  Asp Leu Lys Gln Leu  Thr Val Val 
    2375                 2380                 2385             


Met Glu  His Tyr Leu Glu Glu  Phe Asn Asn Ile Ser  Lys Ala Pro 
    2390                 2395                 2400             


Met Ser  Leu Val Met Phe Arg  Phe Ala Ile Glu His  Ile Ser Arg 
    2405                 2410                 2415             


Ile Cys  Arg Val Leu Lys Gln  Asp Lys Gly His Leu  Leu Leu Val 
    2420                 2425                 2430             


Gly Ile  Gly Gly Ser Gly Arg  Gln Ser Ala Ala Lys  Leu Ser Thr 
    2435                 2440                 2445             


Phe Met  Asn Ala Tyr Glu Leu  Tyr Gln Ile Glu Ile  Thr Lys Asn 
    2450                 2455                 2460             


Tyr Ala  Gly Asn Asp Trp Arg  Glu Asp Leu Lys Lys  Ile Ile Leu 
    2465                 2470                 2475             


Gln Val  Gly Val Ala Thr Lys  Ser Thr Val Phe Leu  Phe Ala Asp 
    2480                 2485                 2490             


Asn Gln  Ile Lys Asp Glu Ser  Phe Val Glu Asp Ile  Asn Met Leu 
    2495                 2500                 2505             


Leu Asn  Thr Gly Asp Val Pro  Asn Ile Phe Pro Ala  Asp Glu Lys 
    2510                 2515                 2520             


Ala Asp  Ile Val Glu Lys Met  Gln Thr Ala Ala Arg  Thr Gln Gly 
    2525                 2530                 2535             


Glu Lys  Val Glu Val Thr Pro  Leu Ser Met Tyr Asn  Phe Phe Ile 
    2540                 2545                 2550             


Glu Arg  Val Ile Asn Lys Ile  Ser Phe Ser Leu Ala  Met Ser Pro 
    2555                 2560                 2565             


Ile Gly  Asp Ala Phe Arg Asn  Arg Leu Arg Met Phe  Pro Ser Leu 
    2570                 2575                 2580             


Ile Asn  Cys Cys Thr Ile Asp  Trp Phe Gln Ser Trp  Pro Thr Asp 
    2585                 2590                 2595             


Ala Leu  Glu Leu Val Ala Asn  Lys Phe Leu Glu Asp  Val Glu Leu 
    2600                 2605                 2610             


Asp Asp  Asn Ile Arg Val Glu  Val Val Ser Met Cys  Lys Tyr Phe 
    2615                 2620                 2625             


Gln Glu  Ser Val Lys Lys Leu  Ser Leu Asp Tyr Tyr  Asn Lys Leu 
    2630                 2635                 2640             


Arg Arg  His Asn Tyr Val Thr  Pro Thr Ser Tyr Leu  Glu Leu Ile 
    2645                 2650                 2655             


Leu Thr  Phe Lys Thr Leu Leu  Asn Ser Lys Arg Gln  Glu Val Ala 
    2660                 2665                 2670             


Met Met  Arg Asn Arg Tyr Leu  Thr Gly Leu Gln Lys  Leu Asp Phe 
    2675                 2680                 2685             


Ala Ala  Ser Gln Val Ala Val  Met Gln Arg Glu Leu  Thr Ala Leu 
    2690                 2695                 2700             


Gln Pro  Gln Leu Ile Leu Thr  Ser Glu Glu Thr Ala  Lys Met Met 
    2705                 2710                 2715             


Val Lys  Ile Glu Ala Glu Thr  Arg Glu Ala Asp Gly  Lys Lys Leu 
    2720                 2725                 2730             


Leu Val  Gln Ala Asp Glu Lys  Glu Ala Asn Val Ala  Ala Ala Ile 
    2735                 2740                 2745             


Ala Gln  Gly Ile Lys Asn Glu  Cys Glu Gly Asp Leu  Ala Glu Ala 
    2750                 2755                 2760             


Met Pro  Ala Leu Glu Ala Ala  Leu Ala Ala Leu Asp  Thr Leu Asn 
    2765                 2770                 2775             


Pro Ala  Asp Ile Ser Leu Val  Lys Ser Met Gln Asn  Pro Pro Gly 
    2780                 2785                 2790             


Pro Val  Lys Leu Val Met Glu  Ser Ile Cys Ile Met  Lys Gly Met 
    2795                 2800                 2805             


Lys Pro  Glu Arg Lys Pro Asp  Pro Ser Gly Ser Gly  Lys Met Ile 
    2810                 2815                 2820             


Glu Asp  Tyr Trp Gly Val Ser  Lys Lys Ile Leu Gly  Asp Leu Lys 
    2825                 2830                 2835             


Phe Leu  Glu Ser Leu Lys Thr  Tyr Asp Lys Asp Asn  Ile Pro Pro 
    2840                 2845                 2850             


Leu Thr  Met Lys Arg Ile Arg  Glu Arg Phe Ile Asn  His Pro Glu 
    2855                 2860                 2865             


Phe Gln  Pro Ala Val Ile Lys  Asn Val Ser Ser Ala  Cys Glu Gly 
    2870                 2875                 2880             


Leu Cys  Lys Trp Val Arg Ala  Met Glu Val Tyr Asp  Arg Val Ala 
    2885                 2890                 2895             


Lys Val  Val Ala Pro Lys Arg  Glu Arg Leu Arg Glu  Ala Glu Gly 
    2900                 2905                 2910             


Lys Leu  Ala Ala Gln Met Gln  Lys Leu Asn Gln Lys  Arg Ala Glu 
    2915                 2920                 2925             


Leu Lys  Leu Val Val Asp Arg  Leu Gln Ala Leu Asn  Asp Asp Phe 
    2930                 2935                 2940             


Glu Glu  Met Asn Thr Lys Lys  Lys Asp Leu Glu Glu  Asn Ile Glu 
    2945                 2950                 2955             


Ile Cys  Ser Gln Lys Leu Val  Arg Ala Glu Lys Leu  Ile Ser Gly 
    2960                 2965                 2970             


Leu Gly  Gly Glu Lys Asp Arg  Trp Thr Glu Ala Ala  Arg Gln Leu 
    2975                 2980                 2985             


Gly Ile  Arg Tyr Thr Asn Leu  Thr Gly Asp Val Leu  Leu Ser Ser 
    2990                 2995                 3000             


Gly Thr  Val Ala Tyr Leu Gly  Ala Phe Thr Val Asp  Tyr Arg Val 
    3005                 3010                 3015             


Gln Cys  Gln Asn Gln Trp Leu  Ala Glu Cys Lys Asp  Lys Val Ile 
    3020                 3025                 3030             


Pro Gly  Phe Ser Asp Phe Ser  Leu Ser His Thr Leu  Gly Asp Pro 
    3035                 3040                 3045             


Ile Lys  Ile Arg Ala Trp Gln  Ile Ala Gly Leu Pro  Val Asp Ser 
    3050                 3055                 3060             


Phe Ser  Ile Asp Asn Gly Ile  Ile Val Ser Asn Ser  Arg Arg Trp 
    3065                 3070                 3075             


Ala Leu  Met Ile Asp Pro His  Gly Gln Ala Asn Lys  Trp Ile Lys 
    3080                 3085                 3090             


Asn Met  Glu Lys Ala Asn Lys  Leu Ala Val Ile Lys  Phe Ser Asp 
    3095                 3100                 3105             


Ser Asn  Tyr Met Arg Met Leu  Glu Asn Ala Leu Gln  Leu Gly Thr 
    3110                 3115                 3120             


Pro Val  Leu Ile Glu Asn Ile  Gly Glu Glu Leu Asp  Ala Ser Ile 
    3125                 3130                 3135             


Glu Pro  Ile Leu Leu Lys Ala  Thr Phe Lys Gln Gln  Gly Val Glu 
    3140                 3145                 3150             


Tyr Met  Arg Leu Gly Glu Asn  Ile Ile Glu Tyr Ser  Arg Asp Phe 
    3155                 3160                 3165             


Lys Leu  Tyr Ile Thr Thr Arg  Leu Arg Asn Pro His  Tyr Leu Pro 
    3170                 3175                 3180             


Glu Val  Ala Val Lys Val Cys  Leu Leu Asn Phe Met  Ile Thr Pro 
    3185                 3190                 3195             


Leu Gly  Leu Gln Asp Gln Leu  Leu Gly Ile Val Ala  Ala Lys Glu 
    3200                 3205                 3210             


Lys Pro  Glu Leu Glu Glu Lys  Lys Asn Gln Leu Ile  Val Glu Ser 
    3215                 3220                 3225             


Ala Lys  Asn Lys Lys His Leu  Lys Glu Ile Glu Asp  Lys Ile Leu 
    3230                 3235                 3240             


Glu Val  Leu Ser Met Ser Lys  Gly Asn Ile Leu Glu  Asp Glu Thr 
    3245                 3250                 3255             


Ala Ile  Lys Val Leu Ser Ser  Ser Lys Val Leu Ser  Glu Glu Ile 
    3260                 3265                 3270             


Ser Glu  Lys Gln Lys Val Ala  Ser Met Thr Glu Thr  Gln Ile Asp 
    3275                 3280                 3285             


Glu Thr  Arg Met Gly Tyr Lys  Pro Val Ala Val His  Ser Ala Thr 
    3290                 3295                 3300             


Ile Phe  Phe Cys Ile Ser Asp  Leu Ala Asn Ile Glu  Pro Met Tyr 
    3305                 3310                 3315             


Gln Tyr  Ser Leu Thr Trp Phe  Ile Asn Leu Tyr Met  His Ser Leu 
    3320                 3325                 3330             


Thr His  Ser Thr Lys Ser Glu  Glu Leu Asn Leu Arg  Ile Lys Tyr 
    3335                 3340                 3345             


Ile Ile  Asp His Phe Thr Leu  Ser Ile Tyr Asn Asn  Val Cys Arg 
    3350                 3355                 3360             


Ser Leu  Phe Glu Lys Asp Lys  Leu Leu Phe Ser Leu  Leu Leu Thr 
    3365                 3370                 3375             


Ile Gly  Ile Met Lys Gln Lys  Lys Glu Ile Thr Glu  Glu Val Trp 
    3380                 3385                 3390             


Tyr Phe  Leu Leu Thr Gly Gly  Ile Ala Leu Asp Asn  Pro Tyr Pro 
    3395                 3400                 3405             


Asn Pro  Ala Pro Gln Trp Leu  Ser Glu Lys Ala Trp  Ala Glu Ile 
    3410                 3415                 3420             


Val Arg  Ala Ser Ala Leu Pro  Lys Leu His Gly Leu  Met Glu His 
    3425                 3430                 3435             


Leu Glu  Gln Asn Leu Gly Glu  Trp Lys Leu Ile Tyr  Asp Ser Ala 
    3440                 3445                 3450             


Trp Pro  His Glu Glu Gln Leu  Pro Gly Ser Trp Lys  Phe Ser Gln 
    3455                 3460                 3465             


Gly Leu  Glu Lys Met Val Ile  Leu Arg Cys Leu Arg  Pro Asp Lys 
    3470                 3475                 3480             


Met Val  Pro Ala Val Arg Glu  Phe Ile Ala Glu His  Met Gly Lys 
    3485                 3490                 3495             


Leu Tyr  Ile Glu Ala Pro Thr  Phe Asp Leu Gln Gly  Ser Tyr Asn 
    3500                 3505                 3510             


Asp Ser  Ser Cys Cys Ala Pro  Leu Ile Phe Val Leu  Ser Pro Ser 
    3515                 3520                 3525             


Ala Asp  Pro Met Ala Gly Leu  Leu Lys Phe Ala Asp  Asp Leu Gly 
    3530                 3535                 3540             


Met Gly  Gly Thr Arg Thr Gln  Thr Ile Ser Leu Gly  Gln Gly Gln 
    3545                 3550                 3555             


Gly Pro  Ile Ala Ala Lys Met  Ile Asn Asn Ala Ile  Lys Asp Gly 
    3560                 3565                 3570             


Thr Trp  Val Val Leu Gln Asn  Cys His Leu Ala Ala  Ser Trp Met 
    3575                 3580                 3585             


Pro Thr  Leu Glu Lys Ile Cys  Glu Glu Val Ile Val  Pro Glu Ser 
    3590                 3595                 3600             


Thr Asn  Ala Arg Phe Arg Leu  Trp Leu Thr Ser Tyr  Pro Ser Glu 
    3605                 3610                 3615             


Lys Phe  Pro Val Ser Ile Leu  Gln Asn Gly Ile Lys  Met Thr Asn 
    3620                 3625                 3630             


Glu Pro  Pro Lys Gly Leu Arg  Ala Asn Leu Leu Arg  Ser Tyr Leu 
    3635                 3640                 3645             


Asn Asp  Pro Ile Ser Asp Pro  Val Phe Phe Gln Ser  Cys Ala Lys 
    3650                 3655                 3660             


Ala Val  Met Trp Gln Lys Met  Leu Phe Gly Leu Cys  Phe Phe His 
    3665                 3670                 3675             


Ala Val  Val Gln Glu Arg Arg  Asn Phe Gly Pro Leu  Gly Trp Asn 
    3680                 3685                 3690             


Ile Pro  Tyr Glu Phe Asn Glu  Ser Asp Leu Arg Ile  Ser Met Trp 
    3695                 3700                 3705             


Gln Ile  Gln Met Phe Leu Asn  Asp Tyr Lys Glu Val  Pro Phe Asp 
    3710                 3715                 3720             


Ala Leu  Thr Tyr Leu Thr Gly  Glu Cys Asn Tyr Gly  Gly Arg Val 
    3725                 3730                 3735             


Thr Asp  Asp Lys Asp Arg Arg  Leu Leu Leu Ser Leu  Leu Ser Met 
    3740                 3745                 3750             


Phe Tyr  Cys Lys Glu Ile Glu  Glu Asp Tyr Tyr Ser  Leu Ala Pro 
    3755                 3760                 3765             


Gly Asp  Thr Tyr Tyr Ile Pro  Pro His Gly Ser Tyr  Gln Ser Tyr 
    3770                 3775                 3780             


Ile Asp  Tyr Leu Arg Asn Leu  Pro Ile Thr Ala His  Pro Glu Val 
    3785                 3790                 3795             


Phe Gly  Leu His Glu Asn Ala  Asp Ile Thr Lys Asp  Asn Gln Glu 
    3800                 3805                 3810             


Thr Asn  Gln Leu Phe Glu Gly  Val Leu Leu Thr Leu  Pro Arg Gln 
    3815                 3820                 3825             


Ser Gly  Gly Ser Gly Lys Ser  Pro Gln Glu Val Val  Glu Glu Leu 
    3830                 3835                 3840             


Ala Gln  Asp Ile Leu Ser Lys  Leu Pro Arg Asp Phe  Asp Leu Glu 
    3845                 3850                 3855             


Glu Val  Met Lys Leu Tyr Pro  Val Val Tyr Glu Glu  Ser Met Asn 
    3860                 3865                 3870             


Thr Val  Leu Arg Gln Glu Leu  Ile Arg Phe Asn Arg  Leu Thr Lys 
    3875                 3880                 3885             


Val Val  Arg Arg Ser Leu Ile  Asn Leu Gly Arg Ala  Ile Lys Gly 
    3890                 3895                 3900             


Gln Val  Leu Met Ser Ser Glu  Leu Glu Glu Val Phe  Asn Ser Met 
    3905                 3910                 3915             


Leu Val  Gly Lys Val Pro Ala  Met Trp Ala Ala Lys  Ser Tyr Pro 
    3920                 3925                 3930             


Ser Leu  Lys Pro Leu Gly Gly  Tyr Val Ala Asp Leu  Leu Ala Arg 
    3935                 3940                 3945             


Leu Thr  Phe Phe Gln Glu Trp  Ile Asp Lys Gly Pro  Pro Val Val 
    3950                 3955                 3960             


Phe Trp  Ile Ser Gly Phe Tyr  Phe Thr Gln Ser Phe  Leu Thr Gly 
    3965                 3970                 3975             


Val Ser  Gln Asn Tyr Ala Arg  Lys Tyr Thr Ile Pro  Ile Asp His 
    3980                 3985                 3990             


Ile Gly  Phe Glu Phe Glu Val  Thr Pro Gln Glu Thr  Val Met Glu 
    3995                 4000                 4005             


Asn Asn  Pro Glu Asp Gly Ala  Tyr Ile Lys Gly Leu  Phe Leu Glu 
    4010                 4015                 4020             


Gly Ala  Arg Trp Asp Arg Lys  Thr Met Gln Ile Gly  Glu Ser Leu 
    4025                 4030                 4035             


Pro Lys  Ile Leu Tyr Asp Pro  Leu Pro Ile Ile Trp  Leu Lys Pro 
    4040                 4045                 4050             


Gly Glu  Ser Ala Met Phe Leu  His Gln Asp Ile Tyr  Val Cys Pro 
    4055                 4060                 4065             


Val Tyr  Lys Thr Ser Ala Arg  Arg Gly Thr Leu Ser  Thr Thr Gly 
    4070                 4075                 4080             


His Ser  Thr Asn Tyr Val Leu  Ser Ile Glu Leu Pro  Thr Asp Met 
    4085                 4090                 4095             


Pro Gln  Lys His Trp Ile Asn  Arg Gly Val Ala Ser  Leu Cys Gln 
    4100                 4105                 4110             


Leu Asp  Asn 
    4115     


<210>  3144
<211>  4624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH5__Homo_sapiens__NP_001360

<400>  3144

Met Phe Arg Ile Gly Arg Arg Gln Leu Trp Lys His Ser Val Thr Arg 
1               5                   10                  15      


Val Leu Thr Gln Arg Leu Lys Gly Glu Lys Glu Ala Lys Arg Ala Leu 
            20                  25                  30          


Leu Asp Ala Arg His Asn Tyr Leu Phe Ala Ile Val Ala Ser Cys Leu 
        35                  40                  45              


Asp Leu Asn Lys Thr Glu Val Glu Asp Ala Ile Leu Glu Gly Asn Gln 
    50                  55                  60                  


Ile Glu Arg Ile Asp Gln Leu Phe Ala Val Gly Gly Leu Arg His Leu 
65                  70                  75                  80  


Met Phe Tyr Tyr Gln Asp Val Glu Glu Ala Glu Thr Gly Gln Leu Gly 
                85                  90                  95      


Ser Leu Gly Gly Val Asn Leu Val Ser Gly Lys Ile Lys Lys Pro Lys 
            100                 105                 110         


Val Phe Val Thr Glu Gly Asn Asp Val Ala Leu Thr Gly Val Cys Val 
        115                 120                 125             


Phe Phe Ile Arg Thr Asp Pro Ser Lys Ala Ile Thr Pro Asp Asn Ile 
    130                 135                 140                 


His Gln Glu Val Ser Phe Asn Met Leu Asp Ala Ala Asp Gly Gly Leu 
145                 150                 155                 160 


Leu Asn Ser Val Arg Arg Leu Leu Ser Asp Ile Phe Ile Pro Ala Leu 
                165                 170                 175     


Arg Ala Thr Ser His Gly Trp Gly Glu Leu Glu Gly Leu Gln Asp Ala 
            180                 185                 190         


Ala Asn Ile Arg Gln Glu Phe Leu Ser Ser Leu Glu Gly Phe Val Asn 
        195                 200                 205             


Val Leu Ser Gly Ala Gln Glu Ser Leu Lys Glu Lys Val Asn Leu Arg 
    210                 215                 220                 


Lys Cys Asp Ile Leu Glu Leu Lys Thr Leu Lys Glu Pro Thr Asp Tyr 
225                 230                 235                 240 


Leu Thr Leu Ala Asn Asn Pro Glu Thr Leu Gly Lys Ile Glu Asp Cys 
                245                 250                 255     


Met Lys Val Trp Ile Lys Gln Thr Glu Gln Val Leu Ala Glu Asn Asn 
            260                 265                 270         


Gln Leu Leu Lys Glu Ala Asp Asp Val Gly Pro Arg Ala Glu Leu Glu 
        275                 280                 285             


His Trp Lys Lys Arg Leu Ser Lys Phe Asn Tyr Leu Leu Glu Gln Leu 
    290                 295                 300                 


Lys Ser Pro Asp Val Lys Ala Val Leu Ala Val Leu Ala Ala Ala Lys 
305                 310                 315                 320 


Ser Lys Leu Leu Lys Thr Trp Arg Glu Met Asp Ile Arg Ile Thr Asp 
                325                 330                 335     


Ala Thr Asn Glu Ala Lys Asp Asn Val Lys Tyr Leu Tyr Thr Leu Glu 
            340                 345                 350         


Lys Cys Cys Asp Pro Leu Tyr Ser Ser Asp Pro Leu Ser Met Met Asp 
        355                 360                 365             


Ala Ile Pro Thr Leu Ile Asn Ala Ile Lys Met Ile Tyr Ser Ile Ser 
    370                 375                 380                 


His Tyr Tyr Asn Thr Ser Glu Lys Ile Thr Ser Leu Phe Val Lys Val 
385                 390                 395                 400 


Thr Asn Gln Ile Ile Ser Ala Cys Lys Ala Tyr Ile Thr Asn Asn Gly 
                405                 410                 415     


Thr Ala Ser Ile Trp Asn Gln Pro Gln Asp Val Val Glu Glu Lys Ile 
            420                 425                 430         


Leu Ser Ala Ile Lys Leu Lys Gln Glu Tyr Gln Leu Cys Phe His Lys 
        435                 440                 445             


Thr Lys Gln Lys Leu Lys Gln Asn Pro Asn Ala Lys Gln Phe Asp Phe 
    450                 455                 460                 


Ser Glu Met Tyr Ile Phe Gly Lys Phe Glu Thr Phe His Arg Arg Leu 
465                 470                 475                 480 


Ala Lys Ile Ile Asp Ile Phe Thr Thr Leu Lys Thr Tyr Ser Val Leu 
                485                 490                 495     


Gln Asp Ser Thr Ile Glu Gly Leu Glu Asp Met Ala Thr Lys Tyr Gln 
            500                 505                 510         


Gly Ile Val Ala Thr Ile Lys Lys Lys Glu Tyr Asn Phe Leu Asp Gln 
        515                 520                 525             


Arg Lys Met Asp Phe Asp Gln Asp Tyr Glu Glu Phe Cys Lys Gln Thr 
    530                 535                 540                 


Asn Asp Leu His Asn Glu Leu Arg Lys Phe Met Asp Val Thr Phe Ala 
545                 550                 555                 560 


Lys Ile Gln Asn Thr Asn Gln Ala Leu Arg Met Leu Lys Lys Phe Glu 
                565                 570                 575     


Arg Leu Asn Ile Pro Asn Leu Gly Ile Asp Asp Lys Tyr Gln Leu Ile 
            580                 585                 590         


Leu Glu Asn Tyr Gly Ala Asp Ile Asp Met Ile Ser Lys Leu Tyr Thr 
        595                 600                 605             


Lys Gln Lys Tyr Asp Pro Pro Leu Ala Arg Asn Gln Pro Pro Ile Ala 
    610                 615                 620                 


Gly Lys Ile Leu Trp Ala Arg Gln Leu Phe His Arg Ile Gln Gln Pro 
625                 630                 635                 640 


Met Gln Leu Phe Gln Gln His Pro Ala Val Leu Ser Thr Ala Glu Ala 
                645                 650                 655     


Lys Pro Ile Ile Arg Ser Tyr Asn Arg Met Ala Lys Val Leu Leu Glu 
            660                 665                 670         


Phe Glu Val Leu Phe His Arg Ala Trp Leu Arg Gln Ile Glu Glu Ile 
        675                 680                 685             


His Val Gly Leu Glu Ala Ser Leu Leu Val Lys Ala Pro Gly Thr Gly 
    690                 695                 700                 


Glu Leu Phe Val Asn Phe Asp Pro Gln Ile Leu Ile Leu Phe Arg Glu 
705                 710                 715                 720 


Thr Glu Cys Met Ala Gln Met Gly Leu Glu Val Ser Pro Leu Ala Thr 
                725                 730                 735     


Ser Leu Phe Gln Lys Arg Asp Arg Tyr Lys Arg Asn Phe Ser Asn Met 
            740                 745                 750         


Lys Met Met Leu Ala Glu Tyr Gln Arg Val Lys Ser Lys Ile Pro Ala 
        755                 760                 765             


Ala Ile Glu Gln Leu Ile Val Pro His Leu Ala Lys Val Asp Glu Ala 
    770                 775                 780                 


Leu Gln Pro Gly Leu Ala Ala Leu Thr Trp Thr Ser Leu Asn Ile Glu 
785                 790                 795                 800 


Ala Tyr Leu Glu Asn Thr Phe Ala Lys Ile Lys Asp Leu Glu Leu Leu 
                805                 810                 815     


Leu Asp Arg Val Asn Asp Leu Ile Glu Phe Arg Ile Asp Ala Ile Leu 
            820                 825                 830         


Glu Glu Met Ser Ser Thr Pro Leu Cys Gln Leu Pro Gln Glu Glu Pro 
        835                 840                 845             


Leu Thr Cys Glu Glu Phe Leu Gln Met Thr Lys Asp Leu Cys Val Asn 
    850                 855                 860                 


Gly Ala Gln Ile Leu His Phe Lys Ser Ser Leu Val Glu Glu Ala Val 
865                 870                 875                 880 


Asn Glu Leu Val Asn Met Leu Leu Asp Val Glu Val Leu Ser Glu Glu 
                885                 890                 895     


Glu Ser Glu Lys Ile Ser Asn Glu Asn Ser Val Asn Tyr Lys Asn Glu 
            900                 905                 910         


Ser Ser Ala Lys Arg Glu Glu Gly Asn Phe Asp Thr Leu Thr Ser Ser 
        915                 920                 925             


Ile Asn Ala Arg Ala Asn Ala Leu Leu Leu Thr Thr Val Thr Arg Lys 
    930                 935                 940                 


Lys Lys Glu Thr Glu Met Leu Gly Glu Glu Ala Arg Glu Leu Leu Ser 
945                 950                 955                 960 


His Phe Asn His Gln Asn Met Asp Ala Leu Leu Lys Val Thr Arg Asn 
                965                 970                 975     


Thr Leu Glu Ala Ile Arg Lys Arg Ile His Ser Ser His Thr Ile Asn 
            980                 985                 990         


Phe Arg Asp Ser Asn Ser Ala Ser  Asn Met Lys Gln Asn  Ser Leu Pro 
        995                 1000                 1005             


Ile Phe  Arg Ala Ser Val Thr  Leu Ala Ile Pro Asn  Ile Val Met 
    1010                 1015                 1020             


Ala Pro  Ala Leu Glu Asp Val  Gln Gln Thr Leu Asn  Lys Ala Val 
    1025                 1030                 1035             


Glu Cys  Ile Ile Ser Val Pro  Lys Gly Val Arg Gln  Trp Ser Ser 
    1040                 1045                 1050             


Glu Leu  Leu Ser Lys Lys Lys  Ile Gln Glu Arg Lys  Met Ala Ala 
    1055                 1060                 1065             


Leu Gln  Ser Asn Glu Asp Ser  Asp Ser Asp Val Glu  Met Gly Glu 
    1070                 1075                 1080             


Asn Glu  Leu Gln Asp Thr Leu  Glu Ile Ala Ser Val  Asn Leu Pro 
    1085                 1090                 1095             


Ile Pro  Val Gln Thr Lys Asn  Tyr Tyr Lys Asn Val  Ser Glu Asn 
    1100                 1105                 1110             


Lys Glu  Ile Val Lys Leu Val  Ser Val Leu Ser Thr  Ile Ile Asn 
    1115                 1120                 1125             


Ser Thr  Lys Lys Glu Val Ile  Thr Ser Met Asp Cys  Phe Lys Arg 
    1130                 1135                 1140             


Tyr Asn  His Ile Trp Gln Lys  Gly Lys Glu Glu Ala  Ile Lys Thr 
    1145                 1150                 1155             


Phe Ile  Thr Gln Ser Pro Leu  Leu Ser Glu Phe Glu  Ser Gln Ile 
    1160                 1165                 1170             


Leu Tyr  Phe Gln Asn Leu Glu  Gln Glu Ile Asn Ala  Glu Pro Glu 
    1175                 1180                 1185             


Tyr Val  Cys Val Gly Ser Ile  Ala Leu Tyr Thr Ala  Asp Leu Lys 
    1190                 1195                 1200             


Phe Ala  Leu Thr Ala Glu Thr  Lys Ala Trp Met Val  Val Ile Gly 
    1205                 1210                 1215             


Arg His  Cys Asn Lys Lys Tyr  Arg Ser Glu Met Glu  Asn Ile Phe 
    1220                 1225                 1230             


Met Leu  Ile Glu Glu Phe Asn  Lys Lys Leu Asn Arg  Pro Ile Lys 
    1235                 1240                 1245             


Asp Leu  Asp Asp Ile Arg Ile  Ala Met Ala Ala Leu  Lys Glu Ile 
    1250                 1255                 1260             


Arg Glu  Glu Gln Ile Ser Ile  Asp Phe Gln Val Gly  Pro Ile Glu 
    1265                 1270                 1275             


Glu Ser  Tyr Ala Leu Leu Asn  Arg Tyr Gly Leu Leu  Ile Ala Arg 
    1280                 1285                 1290             


Glu Glu  Ile Asp Lys Val Asp  Thr Leu His Tyr Ala  Trp Glu Lys 
    1295                 1300                 1305             


Leu Leu  Ala Arg Ala Gly Glu  Val Gln Asn Lys Leu  Val Ser Leu 
    1310                 1315                 1320             


Gln Pro  Ser Phe Lys Lys Glu  Leu Ile Ser Ala Val  Glu Val Phe 
    1325                 1330                 1335             


Leu Gln  Asp Cys His Gln Phe  Tyr Leu Asp Tyr Asp  Leu Asn Gly 
    1340                 1345                 1350             


Pro Met  Ala Ser Gly Leu Lys  Pro Gln Glu Ala Ser  Asp Arg Leu 
    1355                 1360                 1365             


Ile Met  Phe Gln Asn Gln Phe  Asp Asn Ile Tyr Arg  Lys Tyr Ile 
    1370                 1375                 1380             


Thr Tyr  Thr Gly Gly Glu Glu  Leu Phe Gly Leu Pro  Ala Thr Gln 
    1385                 1390                 1395             


Tyr Pro  Gln Leu Leu Glu Ile  Lys Lys Gln Leu Asn  Leu Leu Gln 
    1400                 1405                 1410             


Lys Ile  Tyr Thr Leu Tyr Asn  Ser Val Ile Glu Thr  Val Asn Ser 
    1415                 1420                 1425             


Tyr Tyr  Asp Ile Leu Trp Ser  Glu Val Asn Ile Glu  Lys Ile Asn 
    1430                 1435                 1440             


Asn Glu  Leu Leu Glu Phe Gln  Asn Arg Cys Arg Lys  Leu Pro Arg 
    1445                 1450                 1455             


Ala Leu  Lys Asp Trp Gln Ala  Phe Leu Asp Leu Lys  Lys Ile Ile 
    1460                 1465                 1470             


Asp Asp  Phe Ser Glu Cys Cys  Pro Leu Leu Glu Tyr  Met Ala Ser 
    1475                 1480                 1485             


Lys Ala  Met Met Glu Arg His  Trp Glu Arg Ile Thr  Thr Leu Thr 
    1490                 1495                 1500             


Gly His  Ser Leu Asp Val Gly  Asn Glu Ser Phe Lys  Leu Arg Asn 
    1505                 1510                 1515             


Ile Met  Glu Ala Pro Leu Leu  Lys Tyr Lys Glu Glu  Ile Glu Asp 
    1520                 1525                 1530             


Ile Cys  Ile Ser Ala Val Lys  Glu Arg Asp Ile Glu  Gln Lys Leu 
    1535                 1540                 1545             


Lys Gln  Val Ile Asn Glu Trp  Asp Asn Lys Thr Phe  Thr Phe Gly 
    1550                 1555                 1560             


Ser Phe  Lys Thr Arg Gly Glu  Leu Leu Leu Arg Gly  Asp Ser Thr 
    1565                 1570                 1575             


Ser Glu  Ile Ile Ala Asn Met  Glu Asp Ser Leu Met  Leu Leu Gly 
    1580                 1585                 1590             


Ser Leu  Leu Ser Asn Arg Tyr  Asn Met Pro Phe Lys  Ala Gln Ile 
    1595                 1600                 1605             


Gln Lys  Trp Val Gln Tyr Leu  Ser Asn Ser Thr Asp  Ile Ile Glu 
    1610                 1615                 1620             


Ser Trp  Met Thr Val Gln Asn  Leu Trp Ile Tyr Leu  Glu Ala Val 
    1625                 1630                 1635             


Phe Val  Gly Gly Asp Ile Ala  Lys Gln Leu Pro Lys  Glu Ala Lys 
    1640                 1645                 1650             


Arg Phe  Ser Asn Ile Asp Lys  Ser Trp Val Lys Ile  Met Thr Arg 
    1655                 1660                 1665             


Ala His  Glu Val Pro Ser Val  Val Gln Cys Cys Val  Gly Asp Glu 
    1670                 1675                 1680             


Thr Leu  Gly Gln Leu Leu Pro  His Leu Leu Asp Gln  Leu Glu Ile 
    1685                 1690                 1695             


Cys Gln  Lys Ser Leu Thr Gly  Tyr Leu Glu Lys Lys  Arg Leu Cys 
    1700                 1705                 1710             


Phe Pro  Arg Phe Phe Phe Val  Ser Asp Pro Ala Leu  Leu Glu Ile 
    1715                 1720                 1725             


Leu Gly  Gln Ala Ser Asp Ser  His Thr Ile Gln Ala  His Leu Leu 
    1730                 1735                 1740             


Asn Val  Phe Asp Asn Ile Lys  Ser Val Lys Phe His  Glu Lys Ile 
    1745                 1750                 1755             


Tyr Asp  Arg Ile Leu Ser Ile  Ser Ser Gln Glu Gly  Glu Thr Ile 
    1760                 1765                 1770             


Glu Leu  Asp Lys Pro Val Met  Ala Glu Gly Asn Val  Glu Val Trp 
    1775                 1780                 1785             


Leu Asn  Ser Leu Leu Glu Glu  Ser Gln Ser Ser Leu  His Leu Val 
    1790                 1795                 1800             


Ile Arg  Gln Ala Ala Ala Asn  Ile Gln Glu Thr Gly  Phe Gln Leu 
    1805                 1810                 1815             


Thr Glu  Phe Leu Ser Ser Phe  Pro Ala Gln Val Gly  Leu Leu Gly 
    1820                 1825                 1830             


Ile Gln  Met Ile Trp Thr Arg  Asp Ser Glu Glu Ala  Leu Arg Asn 
    1835                 1840                 1845             


Ala Lys  Phe Asp Lys Lys Ile  Met Gln Lys Thr Asn  Gln Ala Phe 
    1850                 1855                 1860             


Leu Glu  Leu Leu Asn Thr Leu  Ile Asp Val Thr Thr  Arg Asp Leu 
    1865                 1870                 1875             


Ser Ser  Thr Glu Arg Val Lys  Tyr Glu Thr Leu Ile  Thr Ile His 
    1880                 1885                 1890             


Val His  Gln Arg Asp Ile Phe  Asp Asp Leu Cys His  Met His Ile 
    1895                 1900                 1905             


Lys Ser  Pro Met Asp Phe Glu  Trp Leu Lys Gln Cys  Arg Phe Tyr 
    1910                 1915                 1920             


Phe Asn  Glu Asp Ser Asp Lys  Met Met Ile His Ile  Thr Asp Val 
    1925                 1930                 1935             


Ala Phe  Ile Tyr Gln Asn Glu  Phe Leu Gly Cys Thr  Asp Arg Leu 
    1940                 1945                 1950             


Val Ile  Thr Pro Leu Thr Asp  Arg Cys Tyr Ile Thr  Leu Ala Gln 
    1955                 1960                 1965             


Ala Leu  Gly Met Ser Met Gly  Gly Ala Pro Ala Gly  Pro Ala Gly 
    1970                 1975                 1980             


Thr Gly  Lys Thr Glu Thr Thr  Lys Asp Met Gly Arg  Cys Leu Gly 
    1985                 1990                 1995             


Lys Tyr  Val Val Val Phe Asn  Cys Ser Asp Gln Met  Asp Phe Arg 
    2000                 2005                 2010             


Gly Leu  Gly Arg Ile Phe Lys  Gly Leu Ala Gln Ser  Gly Ser Trp 
    2015                 2020                 2025             


Gly Cys  Phe Asp Glu Phe Asn  Arg Ile Asp Leu Pro  Val Leu Ser 
    2030                 2035                 2040             


Val Ala  Ala Gln Gln Ile Ser  Ile Ile Leu Thr Cys  Lys Lys Glu 
    2045                 2050                 2055             


His Lys  Lys Ser Phe Ile Phe  Thr Asp Gly Asp Asn  Val Thr Met 
    2060                 2065                 2070             


Asn Pro  Glu Phe Gly Leu Phe  Leu Thr Met Asn Pro  Gly Tyr Ala 
    2075                 2080                 2085             


Gly Arg  Gln Glu Leu Pro Glu  Asn Leu Lys Ile Asn  Phe Arg Ser 
    2090                 2095                 2100             


Val Ala  Met Met Val Pro Asp  Arg Gln Ile Ile Ile  Arg Val Lys 
    2105                 2110                 2115             


Leu Ala  Ser Cys Gly Phe Ile  Asp Asn Val Val Leu  Ala Arg Lys 
    2120                 2125                 2130             


Phe Phe  Thr Leu Tyr Lys Leu  Cys Glu Glu Gln Leu  Ser Lys Gln 
    2135                 2140                 2145             


Val His  Tyr Asp Phe Gly Leu  Arg Asn Ile Leu Ser  Val Leu Arg 
    2150                 2155                 2160             


Thr Leu  Gly Ala Ala Lys Arg  Ala Asn Pro Met Asp  Thr Glu Ser 
    2165                 2170                 2175             


Thr Ile  Val Met Arg Val Leu  Arg Asp Met Asn Leu  Ser Lys Leu 
    2180                 2185                 2190             


Ile Asp  Glu Asp Glu Pro Leu  Phe Leu Ser Leu Ile  Glu Asp Leu 
    2195                 2200                 2205             


Phe Pro  Asn Ile Leu Leu Asp  Lys Ala Gly Tyr Pro  Glu Leu Glu 
    2210                 2215                 2220             


Ala Ala  Ile Ser Arg Gln Val  Glu Glu Ala Gly Leu  Ile Asn His 
    2225                 2230                 2235             


Pro Pro  Trp Lys Leu Lys Val  Ile Gln Leu Phe Glu  Thr Gln Arg 
    2240                 2245                 2250             


Val Arg  His Gly Met Met Thr  Leu Gly Pro Ser Gly  Ala Gly Lys 
    2255                 2260                 2265             


Thr Thr  Cys Ile His Thr Leu  Met Arg Ala Met Thr  Asp Cys Gly 
    2270                 2275                 2280             


Lys Pro  His Arg Glu Met Arg  Met Asn Pro Lys Ala  Ile Thr Ala 
    2285                 2290                 2295             


Pro Gln  Met Phe Gly Arg Leu  Asp Val Ala Thr Asn  Asp Trp Thr 
    2300                 2305                 2310             


Asp Gly  Ile Phe Ser Thr Leu  Trp Arg Lys Thr Leu  Arg Ala Lys 
    2315                 2320                 2325             


Lys Gly  Glu His Ile Trp Ile  Ile Leu Asp Gly Pro  Val Asp Ala 
    2330                 2335                 2340             


Ile Trp  Ile Glu Asn Leu Asn  Ser Val Leu Asp Asp  Asn Lys Thr 
    2345                 2350                 2355             


Leu Thr  Leu Ala Asn Gly Asp  Arg Ile Pro Met Ala  Pro Asn Cys 
    2360                 2365                 2370             


Lys Ile  Ile Phe Glu Pro His  Asn Ile Asp Asn Ala  Ser Pro Ala 
    2375                 2380                 2385             


Thr Val  Ser Arg Asn Gly Met  Val Phe Met Ser Ser  Ser Ile Leu 
    2390                 2395                 2400             


Asp Trp  Ser Pro Ile Leu Glu  Gly Phe Leu Lys Lys  Arg Ser Pro 
    2405                 2410                 2415             


Gln Glu  Ala Glu Ile Leu Arg  Gln Leu Tyr Thr Glu  Ser Phe Pro 
    2420                 2425                 2430             


Asp Leu  Tyr Arg Phe Cys Ile  Gln Asn Leu Glu Tyr  Lys Met Glu 
    2435                 2440                 2445             


Val Leu  Glu Ala Phe Val Ile  Thr Gln Ser Ile Asn  Met Leu Gln 
    2450                 2455                 2460             


Gly Leu  Ile Pro Leu Lys Glu  Gln Gly Gly Glu Val  Ser Gln Ala 
    2465                 2470                 2475             


His Leu  Gly Arg Leu Phe Val  Phe Ala Leu Leu Trp  Ser Ala Gly 
    2480                 2485                 2490             


Ala Ala  Leu Glu Leu Asp Gly  Arg Arg Arg Leu Glu  Leu Trp Leu 
    2495                 2500                 2505             


Arg Ser  Arg Pro Thr Gly Thr  Leu Glu Leu Pro Pro  Pro Ala Gly 
    2510                 2515                 2520             


Pro Gly  Asp Thr Ala Phe Asp  Tyr Tyr Val Ala Pro  Asp Gly Thr 
    2525                 2530                 2535             


Trp Thr  His Trp Asn Thr Arg  Thr Gln Glu Tyr Leu  Tyr Pro Ser 
    2540                 2545                 2550             


Asp Thr  Thr Pro Glu Tyr Gly  Ser Ile Leu Val Pro  Asn Val Asp 
    2555                 2560                 2565             


Asn Val  Arg Thr Asp Phe Leu  Ile Gln Thr Ile Ala  Lys Gln Gly 
    2570                 2575                 2580             


Lys Ala  Val Leu Leu Ile Gly  Glu Gln Gly Thr Ala  Lys Thr Val 
    2585                 2590                 2595             


Ile Ile  Lys Gly Phe Met Ser  Lys Tyr Asp Pro Glu  Cys His Met 
    2600                 2605                 2610             


Ile Lys  Ser Leu Asn Phe Ser  Ser Ala Thr Thr Pro  Leu Met Phe 
    2615                 2620                 2625             


Gln Arg  Thr Ile Glu Ser Tyr  Val Asp Lys Arg Met  Gly Thr Thr 
    2630                 2635                 2640             


Tyr Gly  Pro Pro Ala Gly Lys  Lys Met Thr Val Phe  Ile Asp Asp 
    2645                 2650                 2655             


Val Asn  Met Pro Ile Ile Asn  Glu Trp Gly Asp Gln  Val Thr Asn 
    2660                 2665                 2670             


Glu Ile  Val Arg Gln Leu Met  Glu Gln Asn Gly Phe  Tyr Asn Leu 
    2675                 2680                 2685             


Glu Lys  Pro Gly Glu Phe Thr  Ser Ile Val Asp Ile  Gln Phe Leu 
    2690                 2695                 2700             


Ala Ala  Met Ile His Pro Gly  Gly Gly Arg Asn Asp  Ile Pro Gln 
    2705                 2710                 2715             


Arg Leu  Lys Arg Gln Phe Ser  Ile Phe Asn Cys Thr  Leu Pro Ser 
    2720                 2725                 2730             


Glu Ala  Ser Val Asp Lys Ile  Phe Gly Val Ile Gly  Val Gly His 
    2735                 2740                 2745             


Tyr Cys  Thr Gln Arg Gly Phe  Ser Glu Glu Val Arg  Asp Ser Val 
    2750                 2755                 2760             


Thr Lys  Leu Val Pro Leu Thr  Arg Arg Leu Trp Gln  Met Thr Lys 
    2765                 2770                 2775             


Ile Lys  Met Leu Pro Thr Pro  Ala Lys Phe His Tyr  Val Phe Asn 
    2780                 2785                 2790             


Leu Arg  Asp Leu Ser Arg Val  Trp Gln Gly Met Leu  Asn Thr Thr 
    2795                 2800                 2805             


Ser Glu  Val Ile Lys Glu Pro  Asn Asp Leu Leu Lys  Leu Trp Lys 
    2810                 2815                 2820             


His Glu  Cys Lys Arg Val Ile  Ala Asp Arg Phe Thr  Val Ser Ser 
    2825                 2830                 2835             


Asp Val  Thr Trp Phe Asp Lys  Ala Leu Val Ser Leu  Val Glu Glu 
    2840                 2845                 2850             


Glu Phe  Gly Glu Glu Lys Lys  Leu Leu Val Asp Cys  Gly Ile Asp 
    2855                 2860                 2865             


Thr Tyr  Phe Val Asp Phe Leu  Arg Asp Ala Pro Glu  Ala Ala Gly 
    2870                 2875                 2880             


Glu Thr  Ser Glu Glu Ala Asp  Ala Glu Thr Pro Lys  Ile Tyr Glu 
    2885                 2890                 2895             


Pro Ile  Glu Ser Phe Ser His  Leu Lys Glu Arg Leu  Asn Met Phe 
    2900                 2905                 2910             


Leu Gln  Leu Tyr Asn Glu Ser  Ile Arg Gly Ala Gly  Met Asp Met 
    2915                 2920                 2925             


Val Phe  Phe Ala Asp Ala Met  Val His Leu Val Lys  Ile Ser Arg 
    2930                 2935                 2940             


Val Ile  Arg Thr Pro Gln Gly  Asn Ala Leu Leu Val  Gly Val Gly 
    2945                 2950                 2955             


Gly Ser  Gly Lys Gln Ser Leu  Thr Arg Leu Ala Ser  Phe Ile Ala 
    2960                 2965                 2970             


Gly Tyr  Val Ser Phe Gln Ile  Thr Leu Thr Arg Ser  Tyr Asn Thr 
    2975                 2980                 2985             


Ser Asn  Leu Met Glu Asp Leu  Lys Val Leu Tyr Arg  Thr Ala Gly 
    2990                 2995                 3000             


Gln Gln  Gly Lys Gly Ile Thr  Phe Ile Phe Thr Asp  Asn Glu Ile 
    3005                 3010                 3015             


Lys Asp  Glu Ser Phe Leu Glu  Tyr Met Asn Asn Val  Leu Ser Ser 
    3020                 3025                 3030             


Gly Glu  Val Ser Asn Leu Phe  Ala Arg Asp Glu Ile  Asp Glu Ile 
    3035                 3040                 3045             


Asn Ser  Asp Leu Ala Ser Val  Met Lys Lys Glu Phe  Pro Arg Cys 
    3050                 3055                 3060             


Leu Pro  Thr Asn Glu Asn Leu  His Asp Tyr Phe Met  Ser Arg Val 
    3065                 3070                 3075             


Arg Gln  Asn Leu His Ile Val  Leu Cys Phe Ser Pro  Val Gly Glu 
    3080                 3085                 3090             


Lys Phe  Arg Asn Arg Ala Leu  Lys Phe Pro Ala Leu  Ile Ser Gly 
    3095                 3100                 3105             


Cys Thr  Ile Asp Trp Phe Ser  Arg Trp Pro Lys Asp  Ala Leu Val 
    3110                 3115                 3120             


Ala Val  Ser Glu His Phe Leu  Thr Ser Tyr Asp Ile  Asp Cys Ser 
    3125                 3130                 3135             


Leu Glu  Ile Lys Lys Glu Val  Val Gln Cys Met Gly  Ser Phe Gln 
    3140                 3145                 3150             


Asp Gly  Val Ala Glu Lys Cys  Val Asp Tyr Phe Gln  Arg Phe Arg 
    3155                 3160                 3165             


Arg Ser  Thr His Val Thr Pro  Lys Ser Tyr Leu Ser  Phe Ile Gln 
    3170                 3175                 3180             


Gly Tyr  Lys Phe Ile Tyr Gly  Glu Lys His Val Glu  Val Arg Thr 
    3185                 3190                 3195             


Leu Ala  Asn Arg Met Asn Thr  Gly Leu Glu Lys Leu  Lys Glu Ala 
    3200                 3205                 3210             


Ser Glu  Ser Val Ala Ala Leu  Ser Lys Glu Leu Glu  Ala Lys Glu 
    3215                 3220                 3225             


Lys Glu  Leu Gln Val Ala Asn  Asp Lys Ala Asp Met  Val Leu Lys 
    3230                 3235                 3240             


Glu Val  Thr Met Lys Ala Gln  Ala Ala Glu Lys Val  Lys Ala Glu 
    3245                 3250                 3255             


Val Gln  Lys Val Lys Asp Arg  Ala Gln Ala Ile Val  Asp Ser Ile 
    3260                 3265                 3270             


Ser Lys  Asp Lys Ala Ile Ala  Glu Glu Lys Leu Glu  Ala Ala Lys 
    3275                 3280                 3285             


Pro Ala  Leu Glu Glu Ala Glu  Ala Ala Leu Gln Thr  Ile Arg Pro 
    3290                 3295                 3300             


Ser Asp  Ile Ala Thr Val Arg  Thr Leu Gly Arg Pro  Pro His Leu 
    3305                 3310                 3315             


Ile Met  Arg Ile Met Asp Cys  Val Leu Leu Leu Phe  Gln Arg Lys 
    3320                 3325                 3330             


Val Ser  Ala Val Lys Ile Asp  Leu Glu Lys Ser Cys  Thr Met Pro 
    3335                 3340                 3345             


Ser Trp  Gln Glu Ser Leu Lys  Leu Met Thr Ala Gly  Asn Phe Leu 
    3350                 3355                 3360             


Gln Asn  Leu Gln Gln Phe Pro  Lys Asp Thr Ile Asn  Glu Glu Val 
    3365                 3370                 3375             


Ile Glu  Phe Leu Ser Pro Tyr  Phe Glu Met Pro Asp  Tyr Asn Ile 
    3380                 3385                 3390             


Glu Thr  Ala Lys Arg Val Cys  Gly Asn Val Ala Gly  Leu Cys Ser 
    3395                 3400                 3405             


Trp Thr  Lys Ala Met Ala Ser  Phe Phe Ser Ile Asn  Lys Glu Val 
    3410                 3415                 3420             


Leu Pro  Leu Lys Ala Asn Leu  Val Val Gln Glu Asn  Arg His Leu 
    3425                 3430                 3435             


Leu Ala  Met Gln Asp Leu Gln  Lys Ala Gln Ala Glu  Leu Asp Asp 
    3440                 3445                 3450             


Lys Gln  Ala Glu Leu Asp Val  Val Gln Ala Glu Tyr  Glu Gln Ala 
    3455                 3460                 3465             


Met Thr  Glu Lys Gln Thr Leu  Leu Glu Asp Ala Glu  Arg Cys Arg 
    3470                 3475                 3480             


His Lys  Met Gln Thr Ala Ser  Thr Leu Ile Ser Gly  Leu Ala Gly 
    3485                 3490                 3495             


Glu Lys  Glu Arg Trp Thr Glu  Gln Ser Gln Glu Phe  Ala Ala Gln 
    3500                 3505                 3510             


Thr Lys  Arg Leu Val Gly Asp  Val Leu Leu Ala Thr  Ala Phe Leu 
    3515                 3520                 3525             


Ser Tyr  Ser Gly Pro Phe Asn  Gln Glu Phe Arg Asp  Leu Leu Leu 
    3530                 3535                 3540             


Asn Asp  Trp Arg Lys Glu Met  Lys Ala Arg Lys Ile  Pro Phe Gly 
    3545                 3550                 3555             


Lys Asn  Leu Asn Leu Ser Glu  Met Leu Ile Asp Ala  Pro Thr Ile 
    3560                 3565                 3570             


Ser Glu  Trp Asn Leu Gln Gly  Leu Pro Asn Asp Asp  Leu Ser Ile 
    3575                 3580                 3585             


Gln Asn  Gly Ile Ile Val Thr  Lys Ala Ser Arg Tyr  Pro Leu Leu 
    3590                 3595                 3600             


Ile Asp  Pro Gln Thr Gln Gly  Lys Ile Trp Ile Lys  Asn Lys Glu 
    3605                 3610                 3615             


Ser Arg  Asn Glu Leu Gln Ile  Thr Ser Leu Asn His  Lys Tyr Phe 
    3620                 3625                 3630             


Arg Asn  His Leu Glu Asp Ser  Leu Ser Leu Gly Arg  Pro Leu Leu 
    3635                 3640                 3645             


Ile Glu  Asp Val Gly Glu Glu  Leu Asp Pro Ala Leu  Asp Asn Val 
    3650                 3655                 3660             


Leu Glu  Arg Asn Phe Ile Lys  Thr Gly Ser Thr Phe  Lys Val Lys 
    3665                 3670                 3675             


Val Gly  Asp Lys Glu Val Asp  Val Leu Asp Gly Phe  Arg Leu Tyr 
    3680                 3685                 3690             


Ile Thr  Thr Lys Leu Pro Asn  Pro Ala Tyr Thr Pro  Glu Ile Ser 
    3695                 3700                 3705             


Ala Arg  Thr Ser Ile Ile Asp  Phe Thr Val Thr Met  Lys Gly Leu 
    3710                 3715                 3720             


Glu Asp  Gln Leu Leu Gly Arg  Val Ile Leu Thr Glu  Lys Gln Glu 
    3725                 3730                 3735             


Leu Glu  Lys Glu Arg Thr His  Leu Met Glu Asp Val  Thr Ala Asn 
    3740                 3745                 3750             


Lys Arg  Arg Met Lys Glu Leu  Glu Asp Asn Leu Leu  Tyr Arg Leu 
    3755                 3760                 3765             


Thr Ser  Thr Gln Gly Ser Leu  Val Glu Asp Glu Ser  Leu Ile Val 
    3770                 3775                 3780             


Val Leu  Ser Asn Thr Lys Arg  Thr Ala Glu Glu Val  Thr Gln Lys 
    3785                 3790                 3795             


Leu Glu  Ile Ser Ala Glu Thr  Glu Val Gln Ile Asn  Ser Ala Arg 
    3800                 3805                 3810             


Glu Glu  Tyr Arg Pro Val Ala  Thr Arg Gly Ser Ile  Leu Tyr Phe 
    3815                 3820                 3825             


Leu Ile  Thr Glu Met Arg Leu  Val Asn Glu Met Tyr  Gln Thr Ser 
    3830                 3835                 3840             


Leu Arg  Gln Phe Leu Gly Leu  Phe Asp Leu Ser Leu  Ala Arg Ser 
    3845                 3850                 3855             


Val Lys  Ser Pro Ile Thr Ser  Lys Arg Ile Ala Asn  Ile Ile Glu 
    3860                 3865                 3870             


His Met  Thr Tyr Glu Val Tyr  Lys Tyr Ala Ala Arg  Gly Leu Tyr 
    3875                 3880                 3885             


Glu Glu  His Lys Phe Leu Phe  Thr Leu Leu Leu Thr  Leu Lys Ile 
    3890                 3895                 3900             


Asp Ile  Gln Arg Asn Arg Val  Lys His Glu Glu Phe  Leu Thr Leu 
    3905                 3910                 3915             


Ile Lys  Gly Gly Ala Ser Leu  Asp Leu Lys Ala Cys  Pro Pro Lys 
    3920                 3925                 3930             


Pro Ser  Lys Trp Ile Leu Asp  Ile Thr Trp Leu Asn  Leu Val Glu 
    3935                 3940                 3945             


Leu Ser  Lys Leu Arg Gln Phe  Ser Asp Val Leu Asp  Gln Ile Ser 
    3950                 3955                 3960             


Arg Asn  Glu Lys Met Trp Lys  Ile Trp Phe Asp Lys  Glu Asn Pro 
    3965                 3970                 3975             


Glu Glu  Glu Pro Leu Pro Asn  Ala Tyr Asp Lys Ser  Leu Asp Cys 
    3980                 3985                 3990             


Phe Arg  Arg Leu Leu Leu Ile  Arg Ser Trp Cys Pro  Asp Arg Thr 
    3995                 4000                 4005             


Ile Ala  Gln Ala Arg Lys Tyr  Ile Val Asp Ser Met  Gly Glu Lys 
    4010                 4015                 4020             


Tyr Ala  Glu Gly Val Ile Leu  Asp Leu Glu Lys Thr  Trp Glu Glu 
    4025                 4030                 4035             


Ser Asp  Pro Arg Thr Pro Leu  Ile Cys Leu Leu Ser  Met Gly Ser 
    4040                 4045                 4050             


Asp Pro  Thr Asp Ser Ile Ile  Ala Leu Gly Lys Arg  Leu Lys Ile 
    4055                 4060                 4065             


Glu Thr  Arg Tyr Val Ser Met  Gly Gln Gly Gln Glu  Val His Ala 
    4070                 4075                 4080             


Arg Lys  Leu Leu Gln Gln Thr  Met Ala Asn Gly Gly  Trp Ala Leu 
    4085                 4090                 4095             


Leu Gln  Asn Cys His Leu Gly  Leu Asp Phe Met Asp  Glu Leu Met 
    4100                 4105                 4110             


Asp Ile  Ile Ile Glu Thr Glu  Leu Val His Asp Ala  Phe Arg Leu 
    4115                 4120                 4125             


Trp Met  Thr Thr Glu Ala His  Lys Gln Phe Pro Ile  Thr Leu Leu 
    4130                 4135                 4140             


Gln Met  Ser Ile Lys Phe Ala  Asn Asp Pro Pro Gln  Gly Leu Arg 
    4145                 4150                 4155             


Ala Gly  Leu Lys Arg Thr Tyr  Ser Gly Val Ser Gln  Asp Leu Leu 
    4160                 4165                 4170             


Asp Val  Ser Ser Gly Ser Gln  Trp Lys Pro Met Leu  Tyr Ala Val 
    4175                 4180                 4185             


Ala Phe  Leu His Ser Thr Val  Gln Glu Arg Arg Lys  Phe Gly Ala 
    4190                 4195                 4200             


Leu Gly  Trp Asn Ile Pro Tyr  Glu Phe Asn Gln Ala  Asp Phe Asn 
    4205                 4210                 4215             


Ala Thr  Val Gln Phe Ile Gln  Asn His Leu Asp Asp  Met Asp Val 
    4220                 4225                 4230             


Lys Lys  Gly Val Ser Trp Thr  Thr Ile Arg Tyr Met  Ile Gly Glu 
    4235                 4240                 4245             


Ile Gln  Tyr Gly Gly Arg Val  Thr Asp Asp Tyr Asp  Lys Arg Leu 
    4250                 4255                 4260             


Leu Asn  Thr Phe Ala Lys Val  Trp Phe Ser Glu Asn  Met Phe Gly 
    4265                 4270                 4275             


Pro Asp  Phe Ser Phe Tyr Gln  Gly Tyr Asn Ile Pro  Lys Cys Ser 
    4280                 4285                 4290             


Thr Val  Asp Asn Tyr Leu Gln  Tyr Ile Gln Ser Leu  Pro Ala Tyr 
    4295                 4300                 4305             


Asp Ser  Pro Glu Val Phe Gly  Leu His Pro Asn Ala  Asp Ile Thr 
    4310                 4315                 4320             


Tyr Gln  Ser Lys Leu Ala Lys  Asp Val Leu Asp Thr  Ile Leu Gly 
    4325                 4330                 4335             


Ile Gln  Pro Lys Asp Thr Ser  Gly Gly Gly Asp Glu  Thr Arg Glu 
    4340                 4345                 4350             


Ala Val  Val Ala Arg Leu Ala  Asp Asp Met Leu Glu  Lys Leu Pro 
    4355                 4360                 4365             


Pro Asp  Tyr Val Pro Phe Glu  Val Lys Glu Arg Leu  Gln Lys Met 
    4370                 4375                 4380             


Gly Pro  Phe Gln Pro Met Asn  Ile Phe Leu Arg Gln  Glu Ile Asp 
    4385                 4390                 4395             


Arg Met  Gln Arg Val Leu Ser  Leu Val Arg Ser Thr  Leu Thr Glu 
    4400                 4405                 4410             


Leu Lys  Leu Ala Ile Asp Gly  Thr Ile Ile Met Ser  Glu Asn Leu 
    4415                 4420                 4425             


Arg Asp  Ala Leu Asp Cys Met  Phe Asp Ala Arg Ile  Pro Ala Trp 
    4430                 4435                 4440             


Trp Lys  Lys Ala Ser Trp Ile  Ser Ser Thr Leu Gly  Phe Trp Phe 
    4445                 4450                 4455             


Thr Glu  Leu Ile Glu Arg Asn  Ser Gln Phe Thr Ser  Trp Val Phe 
    4460                 4465                 4470             


Asn Gly  Arg Pro His Cys Phe  Trp Met Thr Gly Phe  Phe Asn Pro 
    4475                 4480                 4485             


Gln Gly  Phe Leu Thr Ala Met  Arg Gln Glu Ile Thr  Arg Ala Asn 
    4490                 4495                 4500             


Lys Gly  Trp Ala Leu Asp Asn  Met Val Leu Cys Asn  Glu Val Thr 
    4505                 4510                 4515             


Lys Trp  Met Lys Asp Asp Ile  Ser Ala Pro Pro Thr  Glu Gly Val 
    4520                 4525                 4530             


Tyr Val  Tyr Gly Leu Tyr Leu  Glu Gly Ala Gly Trp  Asp Lys Arg 
    4535                 4540                 4545             


Asn Met  Lys Leu Ile Glu Ser  Lys Pro Lys Val Leu  Phe Glu Leu 
    4550                 4555                 4560             


Met Pro  Val Ile Arg Ile Tyr  Ala Glu Asn Asn Thr  Leu Arg Asp 
    4565                 4570                 4575             


Pro Arg  Phe Tyr Ser Cys Pro  Ile Tyr Lys Lys Pro  Val Arg Thr 
    4580                 4585                 4590             


Asp Leu  Asn Tyr Ile Ala Ala  Val Asp Leu Arg Thr  Ala Gln Thr 
    4595                 4600                 4605             


Pro Glu  His Trp Val Leu Arg  Gly Val Ala Leu Leu  Cys Asp Val 
    4610                 4615                 4620             


Lys 
    


<210>  3145
<211>  4158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH6__Homo_sapiens__NP_001361

<400>  3145

Met Thr Phe Arg Ala Thr Asp Ser Glu Phe Asp Leu Thr Asn Ile Glu 
1               5                   10                  15      


Glu Tyr Ala Glu Asn Ser Ala Leu Ser Arg Leu Asn Asn Ile Lys Ala 
            20                  25                  30          


Lys Gln Arg Val Ser Tyr Val Thr Ser Thr Glu Asn Glu Ser Asp Thr 
        35                  40                  45              


Gln Ile Leu Thr Phe Arg His Ile Thr Lys Ala Gln Glu Lys Thr Arg 
    50                  55                  60                  


Lys Arg Gln Gln Pro Ile Lys Leu Glu Pro Leu Pro Val Leu Lys Val 
65                  70                  75                  80  


Tyr Gln Asp His Lys Gln Pro Glu Tyr Ile His Glu Gln Asn Arg Phe 
                85                  90                  95      


Gln Leu Met Thr Ala Gly Ile Ile Lys Arg Pro Val Ser Ile Ala Lys 
            100                 105                 110         


Lys Ser Phe Ala Thr Ser Ser Thr Gln Phe Leu Glu His Gln Asp Ala 
        115                 120                 125             


Val Lys Lys Met Gln Ile His Arg Pro Tyr Val Glu Val Phe Ser Pro 
    130                 135                 140                 


Ser Pro Pro Lys Leu Pro His Thr Gly Ile Gly Lys Arg Gly Leu Phe 
145                 150                 155                 160 


Gly Thr Arg Ser Ser Ala Tyr Pro Lys Tyr Thr Phe His Asp Arg Glu 
                165                 170                 175     


Glu Val Val Lys Ala Asn Ile Arg Asp Pro Leu Gln Ile Ile Lys Ile 
            180                 185                 190         


Ile Arg Glu Asn Glu His Leu Gly Phe Leu Tyr Met Ile Pro Ala Val 
        195                 200                 205             


Pro Arg Ser Ser Ile Glu Tyr Asp Thr Tyr Asn Leu Lys Val Val Ser 
    210                 215                 220                 


Tyr Glu Asn Ile Asn Lys Asn Asp Tyr Tyr Thr Ile Ser Gln Arg Ala 
225                 230                 235                 240 


Val Thr His Ile Tyr Asn Glu Asp Ile Glu Phe Ile Glu Ile Asp Arg 
                245                 250                 255     


Trp Glu Gln Glu Tyr Leu Tyr His Arg Glu Leu Thr Lys Ile Pro Ile 
            260                 265                 270         


Phe Ser Leu Phe Arg Lys Trp Lys Ala Phe Ser Val Trp Arg Lys Asn 
        275                 280                 285             


Val Arg Ser Lys Lys Ile Thr Gly Cys Gln Lys Ser Leu Gln Lys Asn 
    290                 295                 300                 


Leu Phe Ile Val Asn Pro His Leu Arg Pro Ala Leu Leu Lys Ile Asn 
305                 310                 315                 320 


Glu Leu Cys Tyr His Leu Ser Phe Met Gly Leu Cys Tyr Ile Glu Lys 
                325                 330                 335     


Cys His Thr Tyr Thr Leu Gln Glu Phe Lys Ala Ala Gln Val Ile Arg 
            340                 345                 350         


Leu Ala Glu Val Thr Glu Arg Leu Gly Glu Phe Arg Asn Glu Ala Lys 
        355                 360                 365             


Tyr Val Val Arg Arg Ala Cys Arg Phe Ala Leu Arg Ala Ala Gly Phe 
    370                 375                 380                 


Val Pro Asp Asp Cys Ala Phe Gly Pro Phe Glu Asp Tyr His Lys Val 
385                 390                 395                 400 


Gln Ser Ser Gly Ser Phe Ile Asn Thr Pro His Glu Leu Pro Thr Tyr 
                405                 410                 415     


Gly Asp Ser Glu Lys Met Thr Tyr Thr Glu Gln Ala Ser Lys Arg His 
            420                 425                 430         


Tyr Cys Met Arg Leu Thr Cys Phe Ile Arg Leu Asn Asp Tyr Leu Ile 
        435                 440                 445             


Glu Asn Thr Met His Ile Leu Thr Val Asn Ala Val Asn Ser Leu Leu 
    450                 455                 460                 


Asn His Leu Thr Asp Lys Leu Lys Arg Thr Pro Ser Ala Asp Val Ile 
465                 470                 475                 480 


Gln Lys Trp Ile Thr Glu Glu Lys Pro Glu Val Pro Asp Lys Lys Gly 
                485                 490                 495     


Thr Leu Met Val Glu Lys Gln Glu Glu Asp Glu Ser Leu Ile Pro Met 
            500                 505                 510         


Phe Leu Thr Glu Leu Met Leu Thr Val Gln Ser Leu Leu Phe Glu Pro 
        515                 520                 525             


Ser Leu Glu Asp Phe Leu Asp Gly Ile Leu Gly Ala Val Asn His Cys 
    530                 535                 540                 


Gln Asn Thr Val Leu Ser Val Pro Asn Leu Val Pro Asp Ser Tyr Phe 
545                 550                 555                 560 


Asp Ala Phe Thr Ser Pro Tyr Ile Asn Asn Lys Leu Glu Gly Lys Thr 
                565                 570                 575     


Cys Gly Thr Gly Pro Ser Leu Ala Ala Val Phe Glu Asp Asp Lys Asn 
            580                 585                 590         


Phe His Thr Ile Ile Ser Gln Ile Lys Glu Thr Ile Gln Ala Ala Phe 
        595                 600                 605             


Glu Ser Ala Arg Ile Tyr Ala Ala Thr Phe Glu Lys Phe Gln Ile Phe 
    610                 615                 620                 


Phe Lys Glu Asn Glu Ser Leu Asp Leu Gln Ala Leu Lys Leu Gln Glu 
625                 630                 635                 640 


Pro Asp Ile Asn Phe Phe Ser Glu Gln Leu Glu Lys Tyr His Lys Gln 
                645                 650                 655     


His Lys Asp Ala Val Ala Leu Arg Pro Thr Arg Asn Val Gly Leu Leu 
            660                 665                 670         


Leu Ile Asp Thr Arg Leu Leu Arg Glu Lys Leu Ile Pro Ser Pro Leu 
        675                 680                 685             


Arg Cys Leu Glu Val Leu Asn Phe Met Leu Pro Arg Gln Ser Lys Lys 
    690                 695                 700                 


Lys Val Asp Ala Ile Ile Phe Glu Ala Gln Asp Ala Glu Tyr Lys Leu 
705                 710                 715                 720 


Glu Phe Val Pro Thr Thr Thr Thr Glu Tyr Val His Ser Leu Leu Phe 
                725                 730                 735     


Leu Asp Glu Ile Gln Glu Arg Ile Glu Ser Leu Glu Asp Glu Gly Asn 
            740                 745                 750         


Ile Val Thr Gln Met Tyr Lys Leu Met Glu Gln Tyr Gln Val Pro Thr 
        755                 760                 765             


Pro Pro Glu Asp Phe Ala Val Phe Ala Thr Met Lys Pro Ser Ile Val 
    770                 775                 780                 


Ala Val Arg Asn Ala Ile Asp Lys Ser Val Gly Asp Arg Glu Ser Ser 
785                 790                 795                 800 


Ile Lys Gln Phe Cys Val His Leu Gly Ser Asp Leu Glu Glu Leu Asn 
                805                 810                 815     


Asn Glu Val Asn Glu Val Lys Leu Gln Ala Gln Asp Pro Gln Ile Leu 
            820                 825                 830         


Asp Ile Ser Ala Asp Gln Asp Lys Ile Arg Leu Ile Leu Asn Asn Leu 
        835                 840                 845             


Gln Ser Val Leu Ala Asp Leu Gln Lys Arg Ala Phe Gln Tyr Lys Ser 
    850                 855                 860                 


Tyr Gln Lys Asn Phe Lys Val Glu Val Ser Lys Phe Glu Ala Leu Glu 
865                 870                 875                 880 


Glu Val Ser Ala Glu Leu Lys Leu Lys Gln Leu Leu Trp Asp Ser Phe 
                885                 890                 895     


Ser Glu Trp Asp Lys Leu Gln Gln Glu Trp Leu Lys Ser Lys Phe Asp 
            900                 905                 910         


Cys Leu Asp Pro Glu Val Leu Asn Gly Gln Val Ser Lys Tyr Ala Lys 
        915                 920                 925             


Phe Val Thr Gln Leu Glu Lys Gly Leu Pro Pro Asn Ser Val Val Pro 
    930                 935                 940                 


Gln Leu Lys Tyr Lys Val Glu Lys Met Lys Glu Lys Leu Pro Val Ile 
945                 950                 955                 960 


Ile Asp Leu Arg Asn Pro Thr Leu Lys Ala Arg His Trp Ala Ala Ile 
                965                 970                 975     


Glu Gln Thr Val Asp Ala Thr Leu Val Asp Ala Glu Ile Pro Leu Thr 
            980                 985                 990         


Leu Glu Arg Leu Ser Gln Leu His  Val Phe Asp Phe Gly  Gln Glu Ile 
        995                 1000                 1005             


Gln Asp  Ile Ser Gly Gln Ala  Ser Gly Glu Ala Ala  Leu Glu Ala 
    1010                 1015                 1020             


Ile Leu  Lys Lys Val Glu Asp  Ser Trp Lys Thr Thr  Glu Phe Val 
    1025                 1030                 1035             


Ile Leu  Pro His Arg Asp Ser  Lys Asp Val Phe Ile  Leu Gly Gly 
    1040                 1045                 1050             


Thr Asp  Asp Ile Gln Val Leu  Leu Asp Asp Ser Thr  Ile Asn Val 
    1055                 1060                 1065             


Ala Thr  Leu Ala Ser Ser Arg  Tyr Leu Gly Pro Leu  Lys Thr Arg 
    1070                 1075                 1080             


Val Asp  Glu Trp Gln Lys Gln  Leu Ala Leu Phe Asn  Gln Thr Leu 
    1085                 1090                 1095             


Glu Glu  Trp Leu Thr Cys Gln  Arg Asn Trp Leu Tyr  Leu Glu Ser 
    1100                 1105                 1110             


Ile Phe  Asn Ala Pro Asp Ile  Gln Arg Gln Leu Pro  Ala Glu Ala 
    1115                 1120                 1125             


Lys Met  Phe Leu Gln Val Asp  Lys Ser Trp Lys Glu  Ile Met Arg 
    1130                 1135                 1140             


Lys Val  Asn Arg Leu Pro Asn  Ala Leu Arg Ala Ala  Thr Gln Pro 
    1145                 1150                 1155             


Gly Leu  Leu Glu Thr Phe Gln  Asn Asn Asn Ala Leu  Leu Asp Gln 
    1160                 1165                 1170             


Ile Gln  Lys Cys Leu Glu Ala  Tyr Leu Glu Ser Lys  Arg Val Ile 
    1175                 1180                 1185             


Phe Pro  Arg Phe Tyr Phe Leu  Ser Asn Asp Glu Leu  Leu Glu Ile 
    1190                 1195                 1200             


Leu Ala  Gln Thr Arg Asn Pro  Gln Ala Val Gln Pro  His Leu Arg 
    1205                 1210                 1215             


Lys Cys  Phe Asp Ser Ile Ser  Lys Leu Glu Phe Ala  Leu Met Pro 
    1220                 1225                 1230             


Pro Ala  Glu Gly Lys Ile Pro  Gly Ile Asp Gly Glu  Pro Glu Lys 
    1235                 1240                 1245             


Val Tyr  Thr Asn Asp Ile Leu  Ala Met Leu Ser Pro  Glu Gly Glu 
    1250                 1255                 1260             


Arg Val  Ser Leu Gly Lys Gly  Leu Lys Ala Arg Gly  Asn Val Glu 
    1265                 1270                 1275             


Glu Trp  Leu Gly Lys Val Glu  Glu Ala Met Phe Thr  Ser Leu Arg 
    1280                 1285                 1290             


Arg Leu  Cys Lys Ala Ala Ile  Ala Asp Tyr Gln Gly  Lys Leu Arg 
    1295                 1300                 1305             


Thr Asp  Trp Val Val Ala Gly  His Pro Ser Gln Val  Ile Leu Thr 
    1310                 1315                 1320             


Val Ser  Gln Ile Met Trp Cys  Arg Asp Leu Thr Glu  Cys Leu Glu 
    1325                 1330                 1335             


Thr Glu  His Ser Asn His Ile  Gln Ala Leu Lys Asn  Phe Glu Lys 
    1340                 1345                 1350             


Val Asn  Phe Glu Arg Leu Asn  Ala Leu Ala Ala Ile  Val Gln Gly 
    1355                 1360                 1365             


Ser Leu  Pro Lys Leu His Arg  Asn Ile Leu Thr Ala  Leu Ile Thr 
    1370                 1375                 1380             


Ile Asp  Val His Ala Arg Asp  Ile Val Thr Glu Leu  Val Gln Ser 
    1385                 1390                 1395             


Lys Val  Glu Thr Val Glu Ser  Phe Asp Trp Gln Arg  Gln Leu Arg 
    1400                 1405                 1410             


Tyr Tyr  Trp Asp Ile Asp Leu  Asp Asn Cys Val Ala  Arg Met Ala 
    1415                 1420                 1425             


Leu Ser  Gln Tyr Thr Tyr Gly  Tyr Glu Tyr Leu Gly  Ala Cys Pro 
    1430                 1435                 1440             


Arg Leu  Val Ile Thr Pro Leu  Thr Asp Arg Cys Tyr  Leu Cys Leu 
    1445                 1450                 1455             


Met Gly  Ala Leu Gln Leu Asp  Leu Gly Gly Ala Pro  Ala Gly Pro 
    1460                 1465                 1470             


Ala Gly  Thr Gly Lys Thr Glu  Thr Thr Lys Asp Leu  Ala Lys Ala 
    1475                 1480                 1485             


Leu Ala  Ile Gln Cys Val Val  Phe Asn Cys Ser Asp  Gly Leu Asp 
    1490                 1495                 1500             


Tyr Lys  Met Met Gly Arg Phe  Phe Ser Gly Leu Ala  Gln Ser Gly 
    1505                 1510                 1515             


Ala Trp  Cys Cys Phe Asp Glu  Phe Asn Arg Ile Asp  Ile Glu Val 
    1520                 1525                 1530             


Leu Ser  Val Ile Ala Gln Gln  Leu Ile Thr Ile Arg  Asn Ala Lys 
    1535                 1540                 1545             


Ala Ala  Lys Leu Ser Arg Phe  Met Phe Glu Gly Arg  Glu Ile Lys 
    1550                 1555                 1560             


Leu Val  Met Thr Cys Ala Ala  Phe Ile Thr Met Asn  Pro Gly Tyr 
    1565                 1570                 1575             


Ala Gly  Arg Thr Glu Leu Pro  Asp Asn Leu Lys Ala  Leu Phe Arg 
    1580                 1585                 1590             


Pro Phe  Ala Met Met Val Pro  Asn Tyr Ala Leu Ile  Ala Glu Val 
    1595                 1600                 1605             


Ile Leu  Tyr Ser Glu Gly Phe  Glu Ser Ser Lys Ile  Leu Ala Arg 
    1610                 1615                 1620             


Lys Met  Thr Gln Met Tyr Lys  Leu Cys Ser Glu Gln  Leu Ser Gln 
    1625                 1630                 1635             


Gln Asp  His Tyr Asp Phe Gly  Met Arg Ala Val Lys  Ser Val Leu 
    1640                 1645                 1650             


Val Met  Ala Gly Ser Leu Lys  Arg Glu Asn Pro Asp  Leu Asn Glu 
    1655                 1660                 1665             


Asp Val  Val Leu Ile Arg Ala  Leu Gln Asp Ser Asn  Leu Pro Lys 
    1670                 1675                 1680             


Phe Leu  Thr Asp Asp Ala Leu  Leu Phe Ser Gly Ile  Ile Ser Asp 
    1685                 1690                 1695             


Leu Phe  Pro Gly Val Gln Ile  Pro Glu His Asp Tyr  Gly Ile Leu 
    1700                 1705                 1710             


Gln Ser  Thr Ile Val Asp Val  Met Asn Arg Gln Asn  Leu Gln Pro 
    1715                 1720                 1725             


Glu Met  Cys Met Val Arg Lys  Val Ile Gln Phe Tyr  Glu Thr Met 
    1730                 1735                 1740             


Leu Val  Arg His Gly Val Met  Leu Val Gly Pro Thr  Gly Gly Gly 
    1745                 1750                 1755             


Lys Thr  Thr Val Tyr Arg Ile  Leu Ala Glu Thr Leu  Gly Asn Leu 
    1760                 1765                 1770             


Gln Lys  Leu Gly Ile Glu Asn  Ser Phe Tyr Gln Ala  Val Lys Thr 
    1775                 1780                 1785             


Tyr Val  Leu Asn Pro Lys Ser  Ile Thr Met Gly Glu  Leu Tyr Gly 
    1790                 1795                 1800             


Glu Val  Asn Asn Leu Thr Leu  Glu Trp Lys Asp Gly  Leu Met Ala 
    1805                 1810                 1815             


Leu Ser  Val Arg Ala Ala Val  Asn Asp Thr Ser Glu  Asp His Lys 
    1820                 1825                 1830             


Trp Ile  Ile Ser Asp Gly Pro  Val Asp Ala Leu Trp  Ile Glu Asn 
    1835                 1840                 1845             


Met Asn  Thr Val Leu Asp Asp  Asn Lys Met Leu Cys  Leu Ala Asn 
    1850                 1855                 1860             


Ser Glu  Arg Ile Lys Leu Thr  Pro Gln Ile His Met  Leu Phe Glu 
    1865                 1870                 1875             


Val Gln  Asp Leu Arg Val Ala  Ser Pro Ala Thr Val  Ser Arg Cys 
    1880                 1885                 1890             


Gly Met  Val Phe Val Asp Pro  Glu Glu Leu Lys Trp  Met Pro Tyr 
    1895                 1900                 1905             


Val Lys  Thr Trp Met Lys Gly  Ile Ser Lys Lys Leu  Thr Glu Glu 
    1910                 1915                 1920             


Thr Gln  Glu Tyr Ile Leu Asn  Leu Phe Gln Arg Tyr  Val Asp Glu 
    1925                 1930                 1935             


Gly Leu  His Phe Ile Asn Lys  Lys Cys Ser Gln Ala  Ile Pro Gln 
    1940                 1945                 1950             


Val Asp  Ile Ser Lys Val Thr  Thr Leu Cys Cys Leu  Leu Glu Ser 
    1955                 1960                 1965             


Leu Ile  Leu Gly Lys Asp Gly  Val Asn Leu Ala Met  Glu Gln Thr 
    1970                 1975                 1980             


Lys Leu  Asn Thr Ile Leu Cys  Gln Thr Phe Val Phe  Cys Tyr Leu 
    1985                 1990                 1995             


Trp Ser  Leu Gly Gly Asn Leu  Thr Glu Asn Tyr Tyr  Asp Ser Phe 
    2000                 2005                 2010             


Asp Thr  Phe Ile Arg Thr Gln  Phe Asp Asp Asn Pro  Asp Ala Arg 
    2015                 2020                 2025             


Leu Pro  Asn Ser Gly Asp Leu  Trp Ser Ile His Met  Asp Phe Asp 
    2030                 2035                 2040             


Thr Lys  Arg Leu Asp Pro Trp  Glu Arg Ile Ile Pro  Thr Phe Lys 
    2045                 2050                 2055             


Tyr Asn  Arg Asp Val Pro Phe  Phe Glu Met Leu Val  Pro Thr Thr 
    2060                 2065                 2070             


Asp Thr  Val Arg Tyr Gly Tyr  Leu Met Glu Lys Leu  Leu Ala Val 
    2075                 2080                 2085             


Lys His  Ser Val Leu Phe Thr  Gly Ile Thr Gly Val  Gly Lys Ser 
    2090                 2095                 2100             


Val Ile  Ala Lys Gly Leu Leu  Asn Lys Ile Gln Glu  Ser Ala Gly 
    2105                 2110                 2115             


Tyr Val  Pro Val Tyr Leu Asn  Phe Ser Ala Gln Thr  Ser Ser Ala 
    2120                 2125                 2130             


Arg Thr  Gln Glu Ile Ile Glu  Ser Lys Leu Glu Arg  Lys Arg Lys 
    2135                 2140                 2145             


Asn Ile  Leu Gly Ala Pro Gly  Asn Lys Arg Ile Val  Ile Phe Val 
    2150                 2155                 2160             


Asp Asp  Leu Asn Met Pro Arg  Leu Asp Arg Tyr Gly  Ser Gln Pro 
    2165                 2170                 2175             


Pro Ile  Glu Leu Leu Arg Gln  Tyr Gln Asp Phe Gly  Gly Phe Tyr 
    2180                 2185                 2190             


Asp Arg  Asn Lys Leu Phe Trp  Lys Glu Ile Gln Asp  Val Thr Ile 
    2195                 2200                 2205             


Ile Ser  Ala Cys Ala Pro Pro  Gly Gly Gly Arg Asn  Pro Val Thr 
    2210                 2215                 2220             


Pro Arg  Phe Ile Arg His Phe  Ser Met Leu Cys Leu  Pro Met Pro 
    2225                 2230                 2235             


Ser Glu  His Ser Leu Lys Gln  Ile Phe Gln Ala Ile  Leu Asn Gly 
    2240                 2245                 2250             


Phe Leu  Ser Asp Phe Pro Pro  Ala Val Lys Gln Thr  Ala Ser Ser 
    2255                 2260                 2265             


Ile Val  Glu Ala Ser Val Glu  Ile Tyr Asn Lys Met  Ser Val Asp 
    2270                 2275                 2280             


Leu Leu  Pro Thr Pro Ala Lys  Ser His Tyr Val Phe  Asn Leu Arg 
    2285                 2290                 2295             


Asp Leu  Ser Lys Cys Val Gln  Gly Ile Leu Gln Cys  Asp Pro Gly 
    2300                 2305                 2310             


Thr Ile  Arg Glu Glu Ile Gln  Ile Phe Arg Leu Phe  Cys His Glu 
    2315                 2320                 2325             


Cys Gln  Arg Val Phe His Asp  Arg Leu Ile Asn Asn  Glu Asp Lys 
    2330                 2335                 2340             


His Tyr  Phe His Val Ile Leu  Thr Glu Met Ala Asn  Lys His Phe 
    2345                 2350                 2355             


Gly Ile  Ala Ile Asp Leu Glu  Tyr Phe Leu Asn Lys  Pro Ile Ile 
    2360                 2365                 2370             


Phe Gly  Asp Phe Ile Lys Phe  Gly Ala Asp Lys Ala  Asp Arg Ile 
    2375                 2380                 2385             


Tyr Asp  Asp Met Pro Asp Ile  Glu Lys Thr Ala Asn  Val Leu Gln 
    2390                 2395                 2400             


Asp Tyr  Leu Asp Asp Tyr Asn  Leu Thr Asn Pro Lys  Glu Val Lys 
    2405                 2410                 2415             


Leu Val  Phe Phe Gln Asp Ala  Ile Glu His Val Ser  Arg Ile Ala 
    2420                 2425                 2430             


Arg Met  Ile Arg Gln Glu Arg  Gly Asn Ala Leu Leu  Val Gly Val 
    2435                 2440                 2445             


Gly Gly  Thr Gly Lys Gln Ser  Leu Thr Arg Leu Ala  Ala His Ile 
    2450                 2455                 2460             


Cys Gly  Tyr Lys Cys Leu Gln  Ile Glu Leu Ser Arg  Gly Tyr Asn 
    2465                 2470                 2475             


Tyr Asp  Ser Phe His Glu Asp  Leu Arg Lys Leu Tyr  Lys Met Ala 
    2480                 2485                 2490             


Gly Val  Glu Asp Lys Asn Met  Val Phe Leu Phe Thr  Asp Thr Gln 
    2495                 2500                 2505             


Ile Val  Val Glu Glu Phe Leu  Glu Asp Ile Asn Asn  Ile Leu Asn 
    2510                 2515                 2520             


Ser Gly  Glu Val Pro Asn Leu  Phe Glu Lys Asp Glu  Leu Glu Gln 
    2525                 2530                 2535             


Val Leu  Ala Ala Thr Arg Pro  Arg Ala Lys Glu Val  Gly Ile Ser 
    2540                 2545                 2550             


Glu Gly  Asn Arg Asp Glu Val  Phe Gln Tyr Phe Ile  Ser Lys Val 
    2555                 2560                 2565             


Arg Gln  Lys Leu His Ile Val  Leu Cys Met Ser Pro  Val Gly Glu 
    2570                 2575                 2580             


Ala Phe  Arg Ser Arg Cys Arg  Met Phe Pro Ser Leu  Val Asn Cys 
    2585                 2590                 2595             


Cys Thr  Ile Asp Trp Phe Val  Gln Trp Pro Arg Glu  Ala Leu Leu 
    2600                 2605                 2610             


Ser Val  Ser Lys Thr Phe Phe  Ser Gln Val Asp Ala  Gly Asn Glu 
    2615                 2620                 2625             


Glu Leu  Lys Glu Lys Leu Pro  Leu Met Cys Val Asn  Val His Leu 
    2630                 2635                 2640             


Ser Val  Ser Ser Met Ala Glu  Arg Tyr Tyr Asn Glu  Leu Arg Arg 
    2645                 2650                 2655             


Arg Tyr  Tyr Thr Thr Pro Thr  Ser Tyr Leu Glu Leu  Ile Asn Leu 
    2660                 2665                 2670             


Tyr Leu  Ser Met Leu Ser Glu  Lys Arg Lys Gln Ile  Ile Ser Ala 
    2675                 2680                 2685             


Arg Asp  Arg Val Lys Asn Gly  Leu Thr Lys Leu Leu  Glu Thr Asn 
    2690                 2695                 2700             


Ile Leu  Val Asp Lys Met Lys  Leu Asp Leu Ser Ala  Leu Glu Pro 
    2705                 2710                 2715             


Val Leu  Leu Ala Lys Ser Glu  Asp Val Glu Ala Leu  Met Glu Lys 
    2720                 2725                 2730             


Leu Ala  Val Asp Gln Glu Ser  Ala Asp Gln Val Arg  Asn Thr Val 
    2735                 2740                 2745             


Gln Glu  Asp Glu Ala Thr Ala  Lys Val Lys Ala Glu  Glu Thr Gln 
    2750                 2755                 2760             


Ala Ile  Ala Asp Asp Ala Gln  Arg Asp Leu Asp Glu  Ala Leu Pro 
    2765                 2770                 2775             


Ala Leu  Asp Ala Ala Asn Lys  Ala Leu Asp Ser Leu  Asp Lys Ala 
    2780                 2785                 2790             


Asp Ile  Ser Glu Ile Arg Val  Phe Thr Lys Pro Pro  Asp Leu Val 
    2795                 2800                 2805             


Met Thr  Val Met Glu Ala Ile  Ser Ile Leu Leu Asn  Ala Lys Pro 
    2810                 2815                 2820             


Asp Trp  Pro Ser Ala Lys Gln  Leu Leu Gly Asp Ser  Asn Phe Leu 
    2825                 2830                 2835             


Lys Arg  Leu Leu Glu Tyr Asp  Lys Glu Asn Ile Lys  Pro Gln Ile 
    2840                 2845                 2850             


Leu Ala  Lys Leu Gln Lys Tyr  Ile Asn Asn Pro Asp  Phe Val Pro 
    2855                 2860                 2865             


Glu Lys  Val Glu Lys Val Ser  Lys Ala Cys Lys Ser  Met Cys Met 
    2870                 2875                 2880             


Trp Val  Arg Ala Met Asp Leu  Tyr Ser Arg Val Val  Lys Val Val 
    2885                 2890                 2895             


Glu Pro  Lys Arg Gln Lys Leu  Arg Ala Ala Gln Ala  Glu Leu Asp 
    2900                 2905                 2910             


Ile Thr  Met Ala Thr Leu Arg  Glu Lys Gln Ala Leu  Leu Arg Gln 
    2915                 2920                 2925             


Val Glu  Asp Gln Ile Gln Ala  Leu Gln Asp Glu Tyr  Asp Lys Gly 
    2930                 2935                 2940             


Val Asn  Glu Lys Glu Ser Leu  Ala Lys Thr Met Ala  Leu Thr Lys 
    2945                 2950                 2955             


Ala Arg  Leu Val Arg Ala Gly  Lys Leu Thr Ala Ala  Leu Glu Asp 
    2960                 2965                 2970             


Glu Gln  Val Arg Trp Glu Glu  Ser Ile Gln Lys Phe  Glu Glu Glu 
    2975                 2980                 2985             


Ile Ser  Asn Ile Thr Gly Asn  Val Phe Ile Ala Ala  Ala Cys Val 
    2990                 2995                 3000             


Ala Tyr  Tyr Gly Ala Phe Thr  Ala Gln Tyr Arg Gln  Ser Leu Ile 
    3005                 3010                 3015             


Glu Cys  Trp Ile Gln Asp Cys  Gln Ser Leu Glu Ile  Pro Ile Asp 
    3020                 3025                 3030             


Pro Ser  Phe Ser Leu Ile Asn  Ile Leu Gly Asp Pro  Tyr Glu Ile 
    3035                 3040                 3045             


Arg Gln  Trp Asn Thr Asp Gly  Leu Pro Arg Asp Leu  Ile Ser Thr 
    3050                 3055                 3060             


Glu Asn  Gly Ile Leu Val Thr  Gln Gly Arg Arg Trp  Pro Leu Met 
    3065                 3070                 3075             


Ile Asp  Pro Gln Asp Gln Ala  Asn Arg Trp Ile Arg  Asn Lys Glu 
    3080                 3085                 3090             


Ser Lys  Ser Gly Leu Lys Ile  Ile Lys Leu Thr Asp  Ser Asn Phe 
    3095                 3100                 3105             


Leu Arg  Ile Leu Glu Asn Ser  Ile Arg Leu Gly Leu  Pro Val Leu 
    3110                 3115                 3120             


Leu Glu  Glu Leu Lys Glu Thr  Leu Asp Pro Ala Leu  Glu Pro Ile 
    3125                 3130                 3135             


Leu Leu  Lys Gln Ile Phe Ile  Ser Gly Gly Arg Leu  Leu Ile Arg 
    3140                 3145                 3150             


Leu Gly  Asp Ser Asp Ile Asp  Tyr Asp Lys Asn Phe  Arg Phe Tyr 
    3155                 3160                 3165             


Met Thr  Thr Lys Met Pro Asn  Pro His Tyr Leu Pro  Glu Val Cys 
    3170                 3175                 3180             


Ile Lys  Val Thr Ile Ile Asn  Phe Thr Val Thr Lys  Ser Gly Leu 
    3185                 3190                 3195             


Glu Asp  Gln Leu Leu Ser Asp  Val Val Arg Leu Glu  Lys Pro Arg 
    3200                 3205                 3210             


Leu Glu  Glu Gln Arg Ile Lys  Leu Ile Val Arg Ile  Asn Thr Asp 
    3215                 3220                 3225             


Lys Asn  Gln Leu Lys Thr Ile  Glu Glu Lys Ile Leu  Arg Met Leu 
    3230                 3235                 3240             


Phe Thr  Ser Glu Gly Asn Ile  Leu Asp Asn Glu Glu  Leu Ile Asp 
    3245                 3250                 3255             


Thr Leu  Gln Asp Ser Lys Ile  Thr Ser Gly Ala Ile  Lys Thr Arg 
    3260                 3265                 3270             


Leu Glu  Glu Ala Glu Ser Thr  Glu Gln Met Ile Asn  Val Ala Arg 
    3275                 3280                 3285             


Glu Lys  Tyr Arg Pro Val Ala  Thr Gln Gly Ser Val  Met Tyr Phe 
    3290                 3295                 3300             


Val Ile  Ala Ser Leu Ser Glu  Ile Asp Pro Met Tyr  Gln Tyr Ser 
    3305                 3310                 3315             


Leu Lys  Tyr Phe Lys Gln Leu  Phe Asn Thr Thr Ile  Glu Thr Ser 
    3320                 3325                 3330             


Val Lys  Thr Glu Asn Leu Gln  Gln Arg Leu Asp Val  Leu Leu Glu 
    3335                 3340                 3345             


Gln Thr  Leu Leu Thr Ala Tyr  Val Asn Val Ser Arg  Gly Leu Phe 
    3350                 3355                 3360             


Glu Gln  His Lys Leu Ile Tyr  Ser Phe Met Leu Cys  Val Glu Met 
    3365                 3370                 3375             


Met Arg  Gln Gln Gly Thr Leu  Ser Asp Ala Glu Trp  Asn Phe Phe 
    3380                 3385                 3390             


Leu Arg  Gly Ser Ala Gly Leu  Glu Lys Glu Arg Pro  Pro Lys Pro 
    3395                 3400                 3405             


Glu Ala  Pro Trp Leu Pro Thr  Ala Thr Trp Phe Ala  Cys Cys Asp 
    3410                 3415                 3420             


Leu Glu  Glu Ser Phe Pro Val  Phe His Gly Leu Thr  Gln Asn Ile 
    3425                 3430                 3435             


Leu Ser  His Pro Ile Ser Ile  Arg Leu Gly Ser Phe  Glu Thr Tyr 
    3440                 3445                 3450             


Ile Asn  Pro Gln Lys Trp Glu  Gly Tyr Ser Lys Met  Lys His Glu 
    3455                 3460                 3465             


Asp Lys  His Met Arg Gln Glu  Lys Glu Ala Ala His  Gln Asp Pro 
    3470                 3475                 3480             


Trp Ser  Ala Gly Leu Ser Ser  Phe His Lys Leu Ile  Leu Ile Lys 
    3485                 3490                 3495             


Cys Cys  Lys Glu Glu Lys Val  Val Phe Ala Leu Thr  Asp Phe Val 
    3500                 3505                 3510             


Ile Glu  Asn Leu Gly Lys Gln  Phe Ile Glu Thr Pro  Pro Val Asp 
    3515                 3520                 3525             


Leu Pro  Thr Leu Tyr Gln Asp  Met Ser Cys Asn Thr  Pro Leu Val 
    3530                 3535                 3540             


Phe Ile  Leu Ser Thr Gly Ser  Asp Pro Met Gly Ala  Phe Gln Arg 
    3545                 3550                 3555             


Phe Ala  Arg Glu Ser Gly Tyr  Ser Glu Arg Val Gln  Ser Ile Ser 
    3560                 3565                 3570             


Leu Gly  Gln Gly Gln Gly Pro  Ile Ala Glu Lys Met  Val Lys Asp 
    3575                 3580                 3585             


Ala Met  Lys Ser Gly Asn Trp  Val Phe Leu Gln Asn  Cys His Leu 
    3590                 3595                 3600             


Ala Val  Ser Trp Met Leu Ala  Met Glu Glu Leu Ile  Lys Thr Phe 
    3605                 3610                 3615             


Thr Asp  Pro Asp Ser Ala Ile  Lys Asp Thr Phe Arg  Leu Phe Leu 
    3620                 3625                 3630             


Ser Ser  Met Pro Ser Asn Thr  Phe Pro Val Thr Val  Leu Gln Asn 
    3635                 3640                 3645             


Ser Val  Lys Val Thr Asn Glu  Pro Pro Lys Gly Leu  Arg Ala Asn 
    3650                 3655                 3660             


Ile Arg  Arg Ala Phe Thr Glu  Met Thr Pro Ser Phe  Phe Glu Glu 
    3665                 3670                 3675             


Asn Ile  Leu Gly Lys Lys Trp  Arg Gln Ile Ile Phe  Gly Ile Cys 
    3680                 3685                 3690             


Phe Phe  His Ala Ile Ile Gln  Glu Arg Lys Lys Phe  Gly Pro Leu 
    3695                 3700                 3705             


Gly Trp  Asn Ile Cys Tyr Glu  Phe Asn Asp Ser Asp  Arg Glu Cys 
    3710                 3715                 3720             


Ala Leu  Leu Asn Leu Lys Leu  Tyr Cys Lys Glu Gly  Lys Ile Pro 
    3725                 3730                 3735             


Trp Asp  Ala Leu Ile Tyr Ile  Thr Gly Glu Ile Thr  Tyr Gly Gly 
    3740                 3745                 3750             


Arg Val  Thr Asp Ser Trp Asp  Gln Arg Cys Leu Arg  Thr Ile Leu 
    3755                 3760                 3765             


Lys Arg  Phe Phe Ser Pro Glu  Thr Leu Glu Glu Asp  Tyr Lys Tyr 
    3770                 3775                 3780             


Ser Glu  Ser Gly Ile Tyr Phe  Ala Pro Met Ala Asp  Ser Leu Gln 
    3785                 3790                 3795             


Glu Phe  Lys Asp Tyr Ile Glu  Asn Leu Pro Leu Ile  Asp Asp Pro 
    3800                 3805                 3810             


Glu Ile  Phe Gly Met His Glu  Asn Ala Asn Leu Val  Phe Gln Tyr 
    3815                 3820                 3825             


Lys Glu  Thr Ser Thr Leu Ile  Asn Thr Ile Leu Glu  Val Gln Pro 
    3830                 3835                 3840             


Arg Ser  Ser Thr Gly Gly Glu  Gly Lys Ser Asn Asp  Glu Ile Val 
    3845                 3850                 3855             


Gln Glu  Leu Val Ala Ser Val  Gln Thr Arg Val Pro  Glu Lys Leu 
    3860                 3865                 3870             


Glu Met  Glu Gly Ala Ser Glu  Ser Leu Phe Val Lys  Asp Leu Gln 
    3875                 3880                 3885             


Gly Arg  Leu Asn Ser Leu Thr  Thr Val Leu Gly Gln  Glu Val Asp 
    3890                 3895                 3900             


Arg Phe  Asn Asn Leu Leu Lys  Leu Ile His Thr Ser  Leu Glu Thr 
    3905                 3910                 3915             


Leu Asn  Lys Ala Ile Ala Gly  Phe Val Val Met Ser  Glu Glu Met 
    3920                 3925                 3930             


Glu Lys  Val Tyr Asn Ser Phe  Leu Asn Asn Gln Val  Pro Ala Leu 
    3935                 3940                 3945             


Trp Ser  Asn Thr Ala Tyr Pro  Ser Leu Lys Pro Leu  Gly Ser Trp 
    3950                 3955                 3960             


Val Lys  Asp Leu Ile Leu Arg  Thr Ser Phe Val Asp  Leu Trp Leu 
    3965                 3970                 3975             


Lys Arg  Gly Gln Pro Lys Ser  Tyr Trp Ile Ser Gly  Phe Phe Phe 
    3980                 3985                 3990             


Pro Gln  Gly Phe Leu Thr Gly  Thr Leu Gln Asn His  Ala Arg Lys 
    3995                 4000                 4005             


Tyr Asn  Leu Pro Ile Asp Glu  Leu Ser Phe Lys Tyr  Ser Val Ile 
    4010                 4015                 4020             


Pro Thr  Tyr Arg Asp Gln Ala  Ala Val Ile Glu Ala  Ala Lys Thr 
    4025                 4030                 4035             


Val Gln  Phe Gly Gln Glu Leu  Pro Met Asp Met Glu  Leu Pro Ser 
    4040                 4045                 4050             


Pro Glu  Asp Gly Val Leu Val  His Gly Met Phe Met  Asp Ala Ser 
    4055                 4060                 4065             


Arg Trp  Asp Asp Lys Glu Met  Val Ile Glu Asp Ala  Leu Pro Gly 
    4070                 4075                 4080             


Gln Met  Asn Pro Val Leu Pro  Val Val His Phe Glu  Pro Gln Gln 
    4085                 4090                 4095             


Asn Tyr  Lys Pro Ser Pro Thr  Leu Tyr His Cys Pro  Leu Tyr Lys 
    4100                 4105                 4110             


Thr Gly  Ala Arg Ala Gly Thr  Leu Ser Thr Thr Gly  His Ser Thr 
    4115                 4120                 4125             


Asn Phe  Val Val Thr Val Leu  Leu Pro Ser Lys Arg  Ser Lys Asp 
    4130                 4135                 4140             


Tyr Trp  Ile Ala Lys Gly Ser  Ala Leu Leu Cys Gln  Leu Ser Glu 
    4145                 4150                 4155             


<210>  3146
<211>  4024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH7__Homo_sapiens__NP_061720

<400>  3146

Met Ser Ser Glu Gln Asp Lys Ser Ala Ser Lys Glu Lys Ser Lys Lys 
1               5                   10                  15      


Pro Val Arg Phe Leu Pro Gln Leu Ser Met Glu Lys Leu Ala Ser Lys 
            20                  25                  30          


Glu Lys Phe Lys Ala Pro Ala Arg Ala Leu Pro Gln Leu Ser Met Val 
        35                  40                  45              


Ser Thr Lys Pro His Trp Gln Gln Ala Ala Pro Ser Phe His Leu Ser 
    50                  55                  60                  


Val Lys Gln Asp Asp Glu Ser Pro Glu Pro Phe Ser Val Lys Asn Glu 
65                  70                  75                  80  


Gln Ser His Ala Glu Tyr Met Glu Arg Phe Gly Lys Lys Gly Lys Leu 
                85                  90                  95      


Pro His Gln Val Asp Asp Ser Tyr Val Gly Pro Ser Thr Ser Lys Ser 
            100                 105                 110         


Lys Gly Lys Ser Pro His Lys Glu Arg Glu Asn Phe Arg Ser Thr Leu 
        115                 120                 125             


Val Asn Val Ile Met Gln Gln Asp Ala Asp Leu Asp Ser Ala Val Pro 
    130                 135                 140                 


Asp Gly Ser Thr Ile Pro Lys Pro Thr Ala Ser Ala Ile Glu Lys Asp 
145                 150                 155                 160 


Ile Leu Arg Tyr Tyr Tyr Tyr Ile His His Gly Ile Asp Thr Asp His 
                165                 170                 175     


Val Ala Pro Met Glu Asp Ser Trp Leu Glu His Val Leu Asp Leu Val 
            180                 185                 190         


Pro Gln His Leu Lys Val Phe Thr Asp Ser Ile Val Thr Leu Ser Asp 
        195                 200                 205             


Glu Met Arg Glu Asp Tyr Leu Leu Ser Val Arg Lys Ser Ile Val Asp 
    210                 215                 220                 


Phe Val Leu Lys Asp Pro Arg Glu Lys Gly Asp Asp Lys Lys Thr Asp 
225                 230                 235                 240 


Glu Leu Pro Ala His Arg Ala Glu Met Glu Ile Leu Pro Lys Pro Trp 
                245                 250                 255     


Arg Lys Ser Phe Leu Ala Ala Ser Ser Tyr Ile Arg Asp His Leu Asn 
            260                 265                 270         


Ala Met Asn Pro Thr Met Leu Ala Val Leu Asp Leu Trp His Thr Asn 
        275                 280                 285             


Phe Lys Lys Leu Arg Leu Val Asp Ile Lys Glu Phe His Asn Cys Gln 
    290                 295                 300                 


Asp Ala Leu Glu Leu Ser Ser Phe Gln Asn Ile Ile Met Arg His Met 
305                 310                 315                 320 


Asp Ser Ala Lys Glu Thr Leu Leu Lys Met Trp Phe Pro Glu Val Gln 
                325                 330                 335     


Asn Ile Tyr Tyr Gln Gly Asn Lys Lys Lys Gln Leu Pro Thr Gly Asp 
            340                 345                 350         


Ser Ser Ala Lys Leu Glu Ser Phe Phe Asn Cys Ala Ala Ala Leu Met 
        355                 360                 365             


Thr Leu Gln Leu Gln Asp Leu Thr Leu Val Ser Met Gln Asp Phe Thr 
    370                 375                 380                 


Asp Leu Ile Ala Gln Pro Pro Asp Ser Val Arg Ala Phe Glu His Pro 
385                 390                 395                 400 


Gly Phe Ile Met Arg Leu Ile Leu Asp Asn Asp Thr Ile Lys Phe Glu 
                405                 410                 415     


Pro Glu Leu Ser Asp Tyr Ile Asp Ile Phe Leu Asn Val Tyr Asp Val 
            420                 425                 430         


Met Ile Lys Ala Val Ser Phe Val Pro Arg Val Glu Thr Lys Leu Tyr 
        435                 440                 445             


Ser Lys Trp Glu Ser Lys Ser Lys Pro Thr Thr Leu Lys Pro Ile Ile 
    450                 455                 460                 


Leu Asn Glu Ile Val Asp Ala His Lys Glu Lys Ile Lys Glu Val Ile 
465                 470                 475                 480 


Met Lys Glu Ser Val Ala Pro Thr Glu His Leu Arg Leu Tyr Asp Lys 
                485                 490                 495     


Tyr Asp Phe Leu Ile Thr Arg Lys Ala Glu Arg Asp Val Asp Asn Phe 
            500                 505                 510         


Leu Ala Glu Asn His Ser Tyr Glu Lys Ile Ile Asp Glu Ile Cys Lys 
        515                 520                 525             


Tyr Gln Lys Leu Ile Glu Glu Ile Gln Tyr Thr Ser Ile Lys Thr Ile 
    530                 535                 540                 


Arg Leu Gly Met Phe Glu Met His Cys Glu Glu Leu Ile Arg Ala Leu 
545                 550                 555                 560 


Val Lys Arg Ala Asp Ile Ile Cys Gly Lys Leu Leu Ala Lys Met Phe 
                565                 570                 575     


Arg Asp His Gln Glu Val Asn Thr Arg Leu Cys Asp Glu Phe Glu Arg 
            580                 585                 590         


Ile Ala Glu Lys Ala Leu Ser Thr Pro Pro Asn Thr Ala Glu Leu Met 
        595                 600                 605             


Glu Met Lys Ala Tyr Ile Gln Lys Val Glu Val Thr Asp Met Ile Glu 
    610                 615                 620                 


Leu Glu Gln Arg Leu Val Asp Ser Lys Asn Cys Leu Ala Phe Leu Ile 
625                 630                 635                 640 


Glu Tyr Val Asn Phe Ser Pro Ala Asp Met Arg Leu Asn Asn Ser Val 
                645                 650                 655     


Phe Gln Trp Tyr Gly Arg Met Gly Glu Ile Phe Glu Glu His Arg Lys 
            660                 665                 670         


Ile Ile Lys Glu Lys Ile Glu Gln Tyr Gln Glu Gly Leu Lys Leu Arg 
        675                 680                 685             


Cys Glu Arg Phe Val Glu Glu Leu Glu Ser Tyr Ala Lys Gln Ser Glu 
    690                 695                 700                 


Glu Phe Tyr Ser Phe Gly Asp Leu Gln Asp Val Gln Arg Tyr Leu Lys 
705                 710                 715                 720 


Lys Ala Gln Ile Leu Asn Gly Lys Leu Asp Leu Ala Ala Asp Lys Ile 
                725                 730                 735     


Glu Gln Phe Asn Ala Glu Glu Glu Ala Phe Gly Trp Leu Pro Ser Val 
            740                 745                 750         


Tyr Pro Gln Arg Lys Lys Ile Gln Asp Gly Leu Asn Pro Tyr Leu Arg 
        755                 760                 765             


Leu Tyr Glu Thr Ala Val Glu Phe Ser Ser Asn Tyr Arg Ala Trp Thr 
    770                 775                 780                 


Glu Gly Pro Tyr His Lys Val Asn Pro Asp Gln Val Glu Ala Asp Ile 
785                 790                 795                 800 


Gly Asn Tyr Trp Arg Gly Leu Tyr Lys Leu Glu Lys Thr Phe His Asp 
                805                 810                 815     


Ser Pro Tyr Ala Leu Ala Met Thr Lys Lys Val Arg Ser Lys Val Glu 
            820                 825                 830         


Asp Phe Lys Gln His Ile Pro Leu Ile Gln Val Ile Cys Asn Pro Gly 
        835                 840                 845             


Leu Arg Pro Arg His Trp Glu Ala Met Ser Ala Ile Val Gly Tyr Pro 
    850                 855                 860                 


Leu Gln Pro Ser Asp Asp Ser Thr Val Ser Ser Phe Leu Asp Met Asn 
865                 870                 875                 880 


Leu Glu Pro Tyr Ile Asp Arg Phe Glu Gly Ile Ser Glu Ala Ala Ser 
                885                 890                 895     


Lys Glu Tyr Ser Leu Glu Lys Ala Met Glu Lys Met Ile Thr Glu Trp 
            900                 905                 910         


Asp Ala Val Glu Phe Val Ile His Ser Tyr Arg Glu Thr Gly Thr Phe 
        915                 920                 925             


Ile Leu Ala Ser Val Asp Glu Ile Gln Met Leu Leu Asp Asp His Ile 
    930                 935                 940                 


Ile Lys Thr Gln Thr Met Arg Gly Ser Pro Phe Ile Lys Pro Tyr Glu 
945                 950                 955                 960 


Lys Gln Met Arg Glu Trp Glu Gly Lys Leu Leu Leu Leu Gln Glu Ile 
                965                 970                 975     


Leu Asp Glu Trp Leu Lys Val Gln Ala Thr Trp Leu Tyr Leu Glu Pro 
            980                 985                 990         


Ile Phe Ser Ser Pro Asp Ile Met  Ser Gln Met Pro Glu  Glu Gly Arg 
        995                 1000                 1005             


Arg Phe  Thr Ala Val Asp Lys  Thr Trp Arg Asp Ile  Met Arg Ser 
    1010                 1015                 1020             


Val Met  Gln Asp Lys His Val  Leu Thr Val Val Thr  Ile Asp Arg 
    1025                 1030                 1035             


Met Leu  Glu Arg Leu Lys Lys  Ser Asn Glu Leu Leu  Glu Leu Ile 
    1040                 1045                 1050             


Leu Lys  Gly Leu Asn Glu Tyr  Leu Glu Lys Lys Arg  Leu Phe Phe 
    1055                 1060                 1065             


Pro Arg  Phe Phe Phe Leu Ser  Asn Asp Glu Leu Leu  Glu Ile Leu 
    1070                 1075                 1080             


Ser Glu  Thr Lys Asp Pro Thr  Arg Val Gln Pro His  Leu Lys Lys 
    1085                 1090                 1095             


Cys Phe  Glu Gly Ile Ala Lys  Val Glu Phe Thr Glu  Thr Leu Asp 
    1100                 1105                 1110             


Ile Thr  His Met Lys Ser Ser  Glu Gly Glu Val Val  Glu Leu Ile 
    1115                 1120                 1125             


Glu Ile  Ile Ser Thr Ala Lys  Ala Arg Gly Gln Val  Glu Lys Trp 
    1130                 1135                 1140             


Leu Val  Glu Leu Glu Arg Val  Met Ile Asn Ser Ile  His Lys Val 
    1145                 1150                 1155             


Thr Gly  Asp Ala Thr Phe Ala  Tyr Thr Lys Tyr Glu  Arg Ile Asn 
    1160                 1165                 1170             


Trp Val  Arg Asp Trp Pro Gly  Gln Thr Val Leu Cys  Val Ser Gln 
    1175                 1180                 1185             


Ile Phe  Trp Thr Lys Glu Val  Gln Thr Ala Ile Pro  Met Gly Ile 
    1190                 1195                 1200             


Lys Ala  Leu Glu Gln Tyr Leu  Lys Thr Cys Asn Arg  Gln Ile Asp 
    1205                 1210                 1215             


Asp Ile  Val Thr Leu Val Arg  Gly Lys Leu Ser Met  Gln Asn Arg 
    1220                 1225                 1230             


Val Thr  Leu Gly Ala Leu Val  Val Leu Asp Val His  Ala Arg Asp 
    1235                 1240                 1245             


Val Leu  Ser Ser Leu Val Lys  Lys Asn Ile Ser Asp  Asp Ser Asp 
    1250                 1255                 1260             


Phe Glu  Trp Leu Ser Gln Leu  Arg Tyr Tyr Trp Gln  Glu Asn His 
    1265                 1270                 1275             


Leu Glu  Thr Lys Met Ile Asn  Ala Gly Leu Arg Tyr  Gly Tyr Glu 
    1280                 1285                 1290             


Tyr Leu  Gly Asn Ser Pro Arg  Leu Val Ile Thr Pro  Leu Thr Asp 
    1295                 1300                 1305             


Arg Cys  Tyr Arg Thr Leu Phe  Gly Ala Leu His Leu  His Leu Gly 
    1310                 1315                 1320             


Gly Ala  Pro Glu Gly Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Thr 
    1325                 1330                 1335             


Lys Asp  Leu Ala Lys Ala Val  Ala Lys Gln Cys Val  Val Phe Asn 
    1340                 1345                 1350             


Cys Ser  Asp Gly Leu Asp Tyr  Leu Ala Leu Gly Lys  Phe Phe Lys 
    1355                 1360                 1365             


Gly Leu  Leu Ser Cys Gly Ala  Trp Ala Cys Phe Asp  Glu Phe Asn 
    1370                 1375                 1380             


Arg Ile  Asp Leu Glu Val Leu  Ser Val Val Ala Gln  Gln Ile Leu 
    1385                 1390                 1395             


Thr Ile  Gln Arg Gly Ile Asn  Ala Gly Ala Asp Ile  Leu Met Phe 
    1400                 1405                 1410             


Glu Gly  Thr Glu Leu Lys Leu  Asp Pro Thr Cys Ala  Val Phe Ile 
    1415                 1420                 1425             


Thr Met  Asn Pro Gly Tyr Ala  Gly Arg Ser Glu Leu  Pro Asp Asn 
    1430                 1435                 1440             


Leu Lys  Ala Leu Phe Arg Thr  Val Ala Met Met Val  Pro Asp Tyr 
    1445                 1450                 1455             


Ala Met  Ile Ala Glu Ile Val  Leu Tyr Ser Cys Gly  Phe Val Thr 
    1460                 1465                 1470             


Ala Arg  Pro Leu Ser Val Lys  Ile Val Ala Thr Tyr  Arg Leu Cys 
    1475                 1480                 1485             


Ser Glu  Gln Leu Ser Ser Gln  His His Tyr Asp Tyr  Gly Met Arg 
    1490                 1495                 1500             


Ala Val  Lys Ser Val Leu Thr  Ala Ala Gly Asn Leu  Lys Leu Lys 
    1505                 1510                 1515             


Tyr Pro  Asn Glu Asn Glu Glu  Ile Leu Leu Leu Arg  Ser Ile Ile 
    1520                 1525                 1530             


Asp Val  Asn Leu Pro Lys Phe  Leu Ser His Asp Leu  Pro Leu Phe 
    1535                 1540                 1545             


Glu Gly  Ile Thr Ser Asp Leu  Phe Pro Gly Val Lys  Leu Pro Lys 
    1550                 1555                 1560             


Pro Asp  Tyr Asn Asp Leu Leu  Ala Ala Ile Lys Asp  Asn Cys Ala 
    1565                 1570                 1575             


Ser Met  Asn Leu Gln Met Thr  Ala Phe Phe Ser Glu  Lys Ile Leu 
    1580                 1585                 1590             


Gln Val  Tyr Glu Met Met Ile  Val Arg His Gly Phe  Met Ile Val 
    1595                 1600                 1605             


Gly Glu  Pro Phe Gly Gly Lys  Thr Ser Ala Tyr Arg  Val Leu Ala 
    1610                 1615                 1620             


Gly Ala  Leu Asn Asp Ile Cys  Glu Lys Gly Leu Met  Glu Glu Asn 
    1625                 1630                 1635             


Lys Val  Gln Ile Thr Val Leu  Asn Pro Lys Ser Val  Thr Met Gly 
    1640                 1645                 1650             


Gln Leu  Tyr Gly Gln Phe Asp  Ser Val Ser His Glu  Trp Ser Asp 
    1655                 1660                 1665             


Gly Val  Leu Ala Val Ser Phe  Arg Ala Phe Ala Ser  Ser Val Thr 
    1670                 1675                 1680             


Pro Asp  Arg Lys Trp Leu Ile  Phe Asp Gly Pro Val  Asp Ala Val 
    1685                 1690                 1695             


Trp Ile  Glu Asn Met Asn Thr  Val Leu Asp Asp Asn  Lys Lys Leu 
    1700                 1705                 1710             


Cys Leu  Met Ser Gly Glu Ile  Ile Gln Met Ser Pro  Gln Met Asn 
    1715                 1720                 1725             


Leu Ile  Phe Glu Pro Met Asp  Leu Glu Val Ala Ser  Pro Ala Thr 
    1730                 1735                 1740             


Val Ser  Arg Cys Gly Met Ile  Tyr Met Glu Pro His  Met Leu Gly 
    1745                 1750                 1755             


Trp Arg  Pro Leu Met Leu Ser  Trp Val Asn Leu Leu  Pro Ala Ser 
    1760                 1765                 1770             


Val Ser  Val Ile Gln Lys Glu  Phe Ile Met Gly Leu  Phe Asp Arg 
    1775                 1780                 1785             


Met Val  Pro Val Ser Val Glu  Phe Ile Arg Lys His  Thr Lys Glu 
    1790                 1795                 1800             


Leu Ser  Pro Thr Ser Asp Thr  Asn Leu Val Arg Ser  Leu Met Asn 
    1805                 1810                 1815             


Leu Ile  Asp Cys Phe Met Asp  Asp Phe Ala Asp Glu  Val Lys Leu 
    1820                 1825                 1830             


Lys Glu  Arg Asn Asp Arg Glu  Thr Tyr Ser Leu Leu  Glu Gly Ile 
    1835                 1840                 1845             


Phe Leu  Phe Ser Leu Ile Trp  Ser Val Gly Ala Ser  Cys Thr Asp 
    1850                 1855                 1860             


Asp Asp  Arg Leu Lys Phe Asn  Lys Ile Leu Arg Glu  Leu Met Glu 
    1865                 1870                 1875             


Ser Pro  Ile Ser Asp Arg Thr  Arg Asn Thr Phe Lys  Leu Gln Ser 
    1880                 1885                 1890             


Gly Thr  Glu Gln Thr Ser Ser  Lys Ala Leu Thr Val  Pro Phe Pro 
    1895                 1900                 1905             


Glu Lys  Gly Thr Ile Tyr Asp  Tyr Gln Phe Val Thr  Glu Gly Ile 
    1910                 1915                 1920             


Gly Lys  Trp Glu Pro Trp Ile  Lys Lys Leu Lys Glu  Ala Pro Pro 
    1925                 1930                 1935             


Ile Pro  Lys Asp Val Met Phe  Asn Glu Ile Ile Val  Pro Thr Leu 
    1940                 1945                 1950             


Asp Thr  Ile Arg Tyr Ser Ala  Leu Met Glu Leu Leu  Thr Thr His 
    1955                 1960                 1965             


Gln Lys  Pro Ser Ile Phe Val  Gly Pro Thr Gly Thr  Gly Lys Ser 
    1970                 1975                 1980             


Val Tyr  Ile Thr Asn Phe Leu  Leu Asn Gln Leu Asn  Lys Glu Ile 
    1985                 1990                 1995             


Tyr Lys  Pro Leu Leu Ile Asn  Phe Ser Ala Gln Thr  Thr Ala Ala 
    2000                 2005                 2010             


Gln Thr  Gln Asn Ile Val Met  Ser Lys Leu Asp Lys  Arg Arg Lys 
    2015                 2020                 2025             


Gly Val  Phe Gly Pro Pro Leu  Gly Lys Arg Met Val  Val Phe Val 
    2030                 2035                 2040             


Asp Asp  Val Asn Met Pro Ala  Arg Glu Val Tyr Gly  Ala Gln Pro 
    2045                 2050                 2055             


Pro Ile  Glu Leu Leu Arg Gln  Trp Leu Asp His Trp  Asn Trp Tyr 
    2060                 2065                 2070             


Asp Leu  Lys Asp Cys Ser Met  Ile Lys Leu Val Asp  Ile Gln Ile 
    2075                 2080                 2085             


Met Cys  Ala Met Gly Pro Pro  Gly Gly Gly Arg Asn  Pro Val Thr 
    2090                 2095                 2100             


Pro Arg  Tyr Met Arg His Phe  Asn Ile Ile Thr Ile  Asn Glu Phe 
    2105                 2110                 2115             


Ser Asp  Lys Ser Met Tyr Thr  Ile Phe Ser Arg Ile  Leu Thr Trp 
    2120                 2125                 2130             


His Leu  Glu Ile Cys Tyr Lys  Phe Pro Asp Glu Phe  Leu Asp Leu 
    2135                 2140                 2145             


Thr Thr  Gln Ile Val Asn Gly  Thr Met Thr Leu Tyr  Lys Glu Ala 
    2150                 2155                 2160             


Met Lys  Asn Leu Leu Pro Thr  Pro Ala Lys Ser His  Tyr Leu Phe 
    2165                 2170                 2175             


Asn Leu  Arg Asp Phe Ser Arg  Val Ile Gln Gly Val  Cys Leu Ser 
    2180                 2185                 2190             


Arg Pro  Glu Thr Thr Glu Thr  Thr Glu Val Ile Lys  Arg Leu Trp 
    2195                 2200                 2205             


Val His  Glu Val Leu Arg Val  Tyr Tyr Asp Arg Leu  Leu Asp Asn 
    2210                 2215                 2220             


Thr Asp  Arg Ser Trp Leu Ile  Asn Tyr Ile Gln Glu  Ile Leu Arg 
    2225                 2230                 2235             


Asn Tyr  Met Tyr Glu Asp Phe  His Glu Leu Phe Gln  Arg Leu Asp 
    2240                 2245                 2250             


Phe Asp  Asn Asp Gly Met Val  Glu Ala Asp Asp Leu  Arg Ser Leu 
    2255                 2260                 2265             


Met Phe  Cys Asp Phe His Asp  Pro Lys Arg Glu Asp  Thr Asn Tyr 
    2270                 2275                 2280             


Arg Glu  Ile Ala Asp Val Asp  Asn Leu Arg Met Ile  Val Glu Ile 
    2285                 2290                 2295             


His Leu  Glu Glu Tyr Asn Asn  Ile Ser Lys Lys Pro  Met Asn Leu 
    2300                 2305                 2310             


Val Leu  Phe Arg Phe Ala Ile  Glu His Ile Ser Arg  Ile Ser Arg 
    2315                 2320                 2325             


Ile Leu  Lys Gln Pro Arg Ser  His Ala Leu Leu Val  Gly Val Gly 
    2330                 2335                 2340             


Gly Ser  Gly Arg Gln Ser Val  Thr Arg Leu Ala Ala  His Met Ala 
    2345                 2350                 2355             


Asp Tyr  Ser Val Phe Gln Val  Glu Ile Ser Lys Gly  Tyr Asp Thr 
    2360                 2365                 2370             


Thr Glu  Trp His Glu Asp Leu  Lys Val Ile Leu Arg  Lys Cys Ala 
    2375                 2380                 2385             


Glu Gly  Glu Met Gln Gly Val  Phe Leu Phe Thr Asp  Thr Gln Ile 
    2390                 2395                 2400             


Lys Glu  Glu Ser Phe Leu Glu  Asp Val Ser Asn Leu  Leu Asn Ala 
    2405                 2410                 2415             


Gly Glu  Ile Pro Asn Leu Phe  Ala Leu Asp Glu Lys  Gln Glu Ile 
    2420                 2425                 2430             


Cys Asp  Lys Met Arg Gln Leu  Asp Arg Gln Arg Asp  Lys Thr Lys 
    2435                 2440                 2445             


Gln Thr  Asp Gly Ser Pro Ile  Ala Leu Phe Asn Met  Phe Ile Asp 
    2450                 2455                 2460             


His Cys  Arg Ser Gln Leu His  Val Val Leu Ala Met  Ser Pro Ile 
    2465                 2470                 2475             


Gly Asp  Ala Phe Arg Asn Arg  Leu Arg Lys Phe Pro  Ala Leu Val 
    2480                 2485                 2490             


Asn Cys  Cys Thr Ile Asp Trp  Phe Gln Ser Trp Pro  Glu Asp Ala 
    2495                 2500                 2505             


Leu Gln  Ala Val Ala Ser Arg  Phe Leu Glu Glu Ile  Glu Met Ser 
    2510                 2515                 2520             


Glu Glu  Ile Arg Asp Gly Cys  Ile Asp Met Cys Lys  Ser Phe His 
    2525                 2530                 2535             


Thr Ser  Thr Ile Asp Leu Ser  Lys Ser Phe Phe Val  Glu Leu Gln 
    2540                 2545                 2550             


Arg Tyr  Asn Tyr Val Thr Pro  Thr Ser Tyr Leu Glu  Leu Ile Ser 
    2555                 2560                 2565             


Thr Phe  Lys Leu Leu Leu Glu  Lys Lys Arg Ser Glu  Val Met Lys 
    2570                 2575                 2580             


Met Lys  Lys Arg Tyr Glu Val  Gly Leu Glu Lys Leu  Asp Ser Ala 
    2585                 2590                 2595             


Ser Ser  Gln Val Ala Thr Met  Gln Met Glu Leu Glu  Ala Leu His 
    2600                 2605                 2610             


Pro Gln  Leu Lys Val Ala Ser  Lys Glu Val Asp Glu  Met Met Ile 
    2615                 2620                 2625             


Met Ile  Glu Lys Glu Ser Val  Glu Val Ala Lys Thr  Glu Lys Ile 
    2630                 2635                 2640             


Val Lys  Ala Asp Glu Thr Ile  Ala Asn Glu Gln Ala  Met Ala Ser 
    2645                 2650                 2655             


Lys Ala  Ile Lys Asp Glu Cys  Asp Ala Asp Leu Ala  Gly Ala Leu 
    2660                 2665                 2670             


Pro Ile  Leu Glu Ser Ala Leu  Ala Ala Leu Asp Thr  Leu Thr Ala 
    2675                 2680                 2685             


Gln Asp  Ile Thr Val Val Lys  Ser Met Lys Ser Pro  Pro Ala Gly 
    2690                 2695                 2700             


Val Lys  Leu Val Met Glu Ala  Ile Cys Ile Leu Lys  Gly Ile Lys 
    2705                 2710                 2715             


Ala Asp  Lys Ile Pro Asp Pro  Thr Gly Ser Gly Lys  Lys Ile Glu 
    2720                 2725                 2730             


Asp Phe  Trp Gly Pro Ala Lys  Arg Leu Leu Gly Asp  Met Arg Phe 
    2735                 2740                 2745             


Leu Gln  Ser Leu His Glu Tyr  Asp Lys Asp Asn Ile  Pro Pro Ala 
    2750                 2755                 2760             


Tyr Met  Asn Ile Ile Arg Lys  Asn Tyr Ile Pro Asn  Pro Asp Phe 
    2765                 2770                 2775             


Val Pro  Glu Lys Ile Arg Asn  Ala Ser Thr Ala Ala  Glu Gly Leu 
    2780                 2785                 2790             


Cys Lys  Trp Val Ile Ala Met  Asp Ser Tyr Asp Lys  Val Ala Lys 
    2795                 2800                 2805             


Ile Val  Ala Pro Lys Lys Ile  Lys Leu Ala Ala Ala  Glu Gly Glu 
    2810                 2815                 2820             


Leu Lys  Ile Ala Met Asp Gly  Leu Arg Lys Lys Gln  Ala Ala Leu 
    2825                 2830                 2835             


Lys Glu  Val Gln Asp Lys Leu  Ala Arg Leu Gln Asp  Thr Leu Glu 
    2840                 2845                 2850             


Leu Asn  Lys Gln Lys Lys Ala  Asp Leu Glu Asn Gln  Val Asp Leu 
    2855                 2860                 2865             


Cys Ser  Lys Lys Leu Glu Arg  Ala Glu Gln Leu Ile  Gly Gly Leu 
    2870                 2875                 2880             


Gly Gly  Glu Lys Thr Arg Trp  Ser His Thr Ala Leu  Glu Leu Gly 
    2885                 2890                 2895             


Gln Leu  Tyr Ile Asn Leu Thr  Gly Asp Ile Leu Ile  Ser Ser Gly 
    2900                 2905                 2910             


Val Val  Ala Tyr Leu Gly Ala  Phe Thr Ser Thr Tyr  Arg Gln Asn 
    2915                 2920                 2925             


Gln Thr  Lys Glu Trp Thr Thr  Leu Cys Lys Gly Arg  Asp Ile Pro 
    2930                 2935                 2940             


Cys Ser  Asp Asp Cys Ser Leu  Met Gly Thr Leu Gly  Glu Ala Val 
    2945                 2950                 2955             


Thr Ile  Arg Thr Trp Asn Ile  Ala Gly Leu Pro Ser  Asp Ser Phe 
    2960                 2965                 2970             


Ser Ile  Asp Asn Gly Ile Ile  Ile Met Asn Ala Arg  Arg Trp Pro 
    2975                 2980                 2985             


Leu Met  Ile Asp Pro Gln Ser  Gln Ala Asn Lys Trp  Ile Lys Asn 
    2990                 2995                 3000             


Met Glu  Lys Ala Asn Ser Leu  Tyr Val Ile Lys Leu  Ser Glu Pro 
    3005                 3010                 3015             


Asp Tyr  Val Arg Thr Leu Glu  Asn Cys Ile Gln Phe  Gly Thr Pro 
    3020                 3025                 3030             


Val Leu  Leu Glu Asn Val Gly  Glu Glu Leu Asp Pro  Ile Leu Glu 
    3035                 3040                 3045             


Pro Leu  Leu Leu Lys Gln Thr  Phe Lys Gln Gly Gly  Ser Thr Cys 
    3050                 3055                 3060             


Ile Arg  Leu Gly Asp Ser Thr  Ile Glu Tyr Ala Pro  Asp Phe Arg 
    3065                 3070                 3075             


Phe Tyr  Ile Thr Thr Lys Leu  Arg Asn Pro His Tyr  Leu Pro Glu 
    3080                 3085                 3090             


Thr Ser  Val Lys Val Thr Leu  Leu Asn Phe Met Ile  Thr Pro Glu 
    3095                 3100                 3105             


Gly Met  Gln Asp Gln Leu Leu  Gly Ile Val Val Ala  Gln Glu Arg 
    3110                 3115                 3120             


Pro Asp  Leu Glu Glu Glu Lys  Gln Ala Leu Ile Leu  Gln Gly Ala 
    3125                 3130                 3135             


Glu Asn  Lys Arg Gln Leu Lys  Glu Ile Glu Asp Lys  Ile Leu Glu 
    3140                 3145                 3150             


Val Leu  Ser Ser Ser Glu Gly  Asn Ile Leu Glu Asp  Glu Thr Ala 
    3155                 3160                 3165             


Ile Lys  Ile Leu Ser Ser Ser  Lys Ala Leu Ala Asn  Glu Ile Ser 
    3170                 3175                 3180             


Gln Lys  Gln Glu Val Ala Glu  Glu Thr Glu Lys Lys  Ile Asp Thr 
    3185                 3190                 3195             


Thr Arg  Met Gly Tyr Arg Pro  Ile Ala Ile His Ser  Ser Ile Leu 
    3200                 3205                 3210             


Phe Phe  Ser Leu Ala Asp Leu  Ala Asn Ile Glu Pro  Met Tyr Gln 
    3215                 3220                 3225             


Tyr Ser  Leu Thr Trp Phe Ile  Asn Leu Phe Ile Leu  Ser Ile Glu 
    3230                 3235                 3240             


Asn Ser  Glu Lys Ser Glu Ile  Leu Ala Lys Arg Leu  Gln Ile Leu 
    3245                 3250                 3255             


Lys Asp  His Phe Thr Tyr Ser  Leu Tyr Val Asn Val  Cys Arg Ser 
    3260                 3265                 3270             


Leu Phe  Glu Lys Asp Lys Leu  Leu Phe Ser Phe Cys  Leu Thr Ile 
    3275                 3280                 3285             


Asn Leu  Leu Leu His Glu Arg  Ala Ile Asn Lys Ala  Glu Trp Arg 
    3290                 3295                 3300             


Phe Leu  Leu Thr Gly Gly Ile  Gly Leu Asp Asn Pro  Tyr Ala Asn 
    3305                 3310                 3315             


Leu Cys  Thr Trp Leu Pro Gln  Lys Ser Trp Asp Glu  Ile Cys Arg 
    3320                 3325                 3330             


Leu Asp  Asp Leu Pro Ala Phe  Lys Thr Ile Arg Arg  Glu Phe Met 
    3335                 3340                 3345             


Arg Leu  Lys Asp Gly Trp Lys  Lys Val Tyr Asp Ser  Leu Glu Pro 
    3350                 3355                 3360             


His His  Glu Val Phe Pro Glu  Glu Trp Glu Asp Lys  Ala Asn Glu 
    3365                 3370                 3375             


Phe Gln  Arg Met Leu Ile Ile  Arg Cys Leu Arg Pro  Asp Lys Val 
    3380                 3385                 3390             


Ile Pro  Met Leu Gln Glu Phe  Ile Ile Asn Arg Leu  Gly Arg Ala 
    3395                 3400                 3405             


Phe Ile  Glu Pro Pro Pro Phe  Asp Leu Ala Lys Ala  Phe Gly Asp 
    3410                 3415                 3420             


Ser Asn  Cys Cys Ala Pro Leu  Ile Phe Val Leu Ser  Pro Gly Ala 
    3425                 3430                 3435             


Asp Pro  Met Ala Ala Leu Leu  Lys Phe Ala Asp Asp  Gln Gly Tyr 
    3440                 3445                 3450             


Gly Gly  Ser Lys Leu Ser Ser  Leu Ser Leu Gly Gln  Gly Gln Gly 
    3455                 3460                 3465             


Pro Ile  Ala Met Lys Met Leu  Glu Lys Ala Val Lys  Glu Gly Thr 
    3470                 3475                 3480             


Trp Val  Val Leu Gln Asn Cys  His Leu Ala Thr Ser  Trp Met Pro 
    3485                 3490                 3495             


Thr Leu  Glu Lys Val Cys Glu  Glu Leu Ser Pro Glu  Ser Thr His 
    3500                 3505                 3510             


Pro Asp  Phe Arg Met Trp Leu  Thr Ser Tyr Pro Ser  Pro Asn Phe 
    3515                 3520                 3525             


Pro Val  Ser Val Leu Gln Asn  Gly Val Lys Met Thr  Asn Glu Ala 
    3530                 3535                 3540             


Pro Lys  Gly Leu Arg Ala Asn  Ile Ile Arg Ser Tyr  Leu Met Asp 
    3545                 3550                 3555             


Pro Ile  Ser Asp Pro Glu Phe  Phe Gly Ser Cys Lys  Lys Pro Glu 
    3560                 3565                 3570             


Glu Phe  Lys Lys Leu Leu Tyr  Gly Leu Cys Phe Phe  His Ala Leu 
    3575                 3580                 3585             


Val Gln  Glu Arg Arg Lys Phe  Gly Pro Leu Gly Trp  Asn Ile Pro 
    3590                 3595                 3600             


Tyr Glu  Phe Asn Glu Thr Asp  Leu Arg Ile Ser Val  Gln Gln Leu 
    3605                 3610                 3615             


His Met  Phe Leu Asn Gln Tyr  Glu Glu Leu Pro Tyr  Glu Ala Leu 
    3620                 3625                 3630             


Arg Tyr  Met Thr Gly Glu Cys  Asn Tyr Gly Gly Arg  Val Thr Asp 
    3635                 3640                 3645             


Asp Trp  Asp Arg Arg Thr Leu  Arg Ser Ile Leu Asn  Lys Phe Phe 
    3650                 3655                 3660             


Asn Pro  Glu Leu Val Glu Asn  Ser Asp Tyr Lys Phe  Asp Ser Ser 
    3665                 3670                 3675             


Gly Ile  Tyr Phe Val Pro Pro  Ser Gly Asp His Lys  Ser Tyr Ile 
    3680                 3685                 3690             


Glu Tyr  Thr Lys Thr Leu Pro  Leu Thr Pro Ala Pro  Glu Ile Phe 
    3695                 3700                 3705             


Gly Met  Asn Ala Asn Ala Asp  Ile Thr Lys Asp Gln  Ser Glu Thr 
    3710                 3715                 3720             


Gln Leu  Leu Phe Asp Asn Ile  Leu Leu Thr Gln Ser  Arg Ser Ala 
    3725                 3730                 3735             


Gly Ala  Gly Ala Lys Ser Ser  Asp Glu Val Val Asn  Glu Val Ala 
    3740                 3745                 3750             


Ser Asp  Ile Leu Gly Lys Leu  Pro Asn Asn Phe Asp  Ile Glu Ala 
    3755                 3760                 3765             


Ala Met  Arg Arg Tyr Pro Thr  Thr Tyr Thr Gln Ser  Met Asn Thr 
    3770                 3775                 3780             


Val Leu  Val Gln Glu Met Gly  Arg Phe Asn Lys Leu  Leu Lys Thr 
    3785                 3790                 3795             


Ile Arg  Asp Ser Cys Val Asn  Ile Gln Lys Ala Ile  Lys Gly Leu 
    3800                 3805                 3810             


Ala Val  Met Ser Thr Asp Leu  Glu Glu Val Val Ser  Ser Ile Leu 
    3815                 3820                 3825             


Asn Val  Lys Ile Pro Glu Met  Trp Met Gly Lys Ser  Tyr Pro Ser 
    3830                 3835                 3840             


Leu Lys  Pro Leu Gly Ser Tyr  Val Asn Asp Phe Leu  Ala Arg Leu 
    3845                 3850                 3855             


Lys Phe  Leu Gln Gln Trp Tyr  Glu Val Gly Pro Pro  Pro Val Phe 
    3860                 3865                 3870             


Trp Leu  Ser Gly Phe Phe Phe  Thr Gln Ala Phe Leu  Thr Gly Ala 
    3875                 3880                 3885             


Gln Gln  Asn Tyr Ala Arg Lys  Tyr Thr Ile Pro Ile  Asp Leu Leu 
    3890                 3895                 3900             


Gly Phe  Asp Tyr Glu Val Met  Glu Asp Lys Glu Tyr  Lys His Pro 
    3905                 3910                 3915             


Pro Glu  Asp Gly Val Phe Ile  His Gly Leu Phe Leu  Asp Gly Ala 
    3920                 3925                 3930             


Ser Trp  Asn Arg Lys Ile Lys  Lys Leu Ala Glu Ser  His Pro Lys 
    3935                 3940                 3945             


Ile Leu  Tyr Asp Thr Val Pro  Val Met Trp Leu Lys  Pro Cys Lys 
    3950                 3955                 3960             


Arg Ala  Asp Ile Pro Lys Arg  Pro Ser Tyr Val Ala  Pro Leu Tyr 
    3965                 3970                 3975             


Lys Thr  Ser Glu Arg Arg Gly  Val Leu Ser Thr Thr  Gly His Ser 
    3980                 3985                 3990             


Thr Asn  Phe Val Ile Ala Met  Thr Leu Pro Ser Asp  Gln Pro Lys 
    3995                 4000                 4005             


Glu His  Trp Ile Gly Arg Gly  Val Ala Leu Leu Cys  Gln Leu Asn 
    4010                 4015                 4020             


Ser 
    


<210>  3147
<211>  4707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH8__Homo_sapiens__NP_001193856

<400>  3147

Met Glu Lys Asp Ala Glu Asp Gly Ala Pro Ser Glu Gly Ala Glu Ala 
1               5                   10                  15      


Pro Pro Ser Thr Glu Glu Ala Ala Pro Pro Arg Ser Glu Glu Glu Glu 
            20                  25                  30          


Ala Pro Arg Pro Pro Thr Val Glu Ala Pro Ala Glu Asp Gly Phe Ser 
        35                  40                  45              


Pro Ser Ala Glu Asp Ala Val Ser Ser Val Val Asp Tyr Arg Asp Leu 
    50                  55                  60                  


Ile Pro Ser Glu Glu Gly Ile Val Leu Pro Asp Asp His Glu Ala Asp 
65                  70                  75                  80  


Leu Asn Arg Val Arg Gln Arg Leu Ala Pro Arg Pro Val Gln Ser Val 
                85                  90                  95      


Ile Ser Glu Val Leu Ser Leu Pro Ser Ser Arg Arg Ser Ser Arg Tyr 
            100                 105                 110         


Arg Arg Ser Met Ser Gly Leu Pro Asn Leu Gln Glu Thr Leu Lys Glu 
        115                 120                 125             


Arg Gln Ala Arg Phe Arg Glu Ala Arg Glu Ser Arg Arg Leu Lys Ile 
    130                 135                 140                 


Asp Pro Ser Tyr Lys Tyr Ile Phe Glu Ile Leu Ala Glu Asn Leu Gly 
145                 150                 155                 160 


Leu Asp Ile Val Thr Val Glu Glu Leu Ile Leu Asp Cys Pro Ser Leu 
                165                 170                 175     


Glu Ala Phe Thr Asn Phe Phe Ala Lys Asp Gly Cys Lys Thr Leu Lys 
            180                 185                 190         


Phe Leu Tyr Gln Glu Gly Asp Val Pro Gly Ile Glu Cys Gly Arg Thr 
        195                 200                 205             


Ile Ala Gly Ala Thr Lys Gly Ala Lys Met Met Lys Leu Tyr Ile Asp 
    210                 215                 220                 


Asn Ala Ala Pro Asp Lys Leu Lys Gly Leu Cys Ile Phe Phe Val Arg 
225                 230                 235                 240 


Cys Arg Asn Asp Val Ala Ile Asn Val Lys Thr Ile Gln Glu Glu Ala 
                245                 250                 255     


Leu Phe Thr Val Leu Asp Ala Ser Lys Gly Leu Leu Asn Gly Ile Arg 
            260                 265                 270         


Asp Met Leu Ala Asn Ile Phe Leu Pro Ala Val Leu Ala Thr Asn Asn 
        275                 280                 285             


Trp Gly Ala Leu Asn Gln Ser Lys Gln Gly Glu Ser Glu Lys His Ile 
    290                 295                 300                 


Phe Thr Glu Thr Ile Asn Arg Tyr Leu Ser Phe Leu Asp Gly Ala Arg 
305                 310                 315                 320 


Ile Ser Ile Glu Gly Thr Val Lys Leu Lys Thr Ile Asp Asn Val Asn 
                325                 330                 335     


Phe Ser Lys Leu His Thr Phe Glu Glu Val Thr Ala Ala Ala Ser Asn 
            340                 345                 350         


Ser Glu Thr Val His Gln Leu Glu Glu Val Leu Met Val Trp Tyr Lys 
        355                 360                 365             


Gln Ile Glu Gln Val Leu Ile Glu Ser Glu Gln Met Arg Lys Glu Ala 
    370                 375                 380                 


Gly Asp Ser Gly Pro Leu Thr Glu Leu Glu His Trp Lys Arg Met Ser 
385                 390                 395                 400 


Ala Lys Phe Asn Tyr Ile Ile Glu Gln Ile Lys Gly Pro Ser Cys Lys 
                405                 410                 415     


Ala Val Ile Asn Val Leu Asn Val Ala His Ser Lys Leu Leu Lys Asn 
            420                 425                 430         


Trp Arg Asp Leu Asp Ala Arg Ile Thr Asp Thr Ala Asn Glu Ser Lys 
        435                 440                 445             


Asp Asn Val Arg Tyr Leu Tyr Thr Leu Glu Lys Val Cys Gln Pro Leu 
    450                 455                 460                 


Tyr Asn His Asp Leu Val Ser Met Ala His Gly Ile Gln Asn Leu Ile 
465                 470                 475                 480 


Asn Ala Ile Arg Met Ile His Gly Val Ser Arg Tyr Tyr Asn Thr Ser 
                485                 490                 495     


Glu Arg Met Thr Ser Leu Phe Ile Lys Val Thr Asn Gln Met Val Thr 
            500                 505                 510         


Ala Cys Lys Ala Tyr Ile Thr Asp Gly Gly Leu Asn His Val Trp Asp 
        515                 520                 525             


Gln Glu Thr Pro Val Val Leu Lys Lys Ile Gln Asp Cys Ile Phe Leu 
    530                 535                 540                 


Phe Lys Glu Tyr Gln Ala Ser Phe His Lys Thr Arg Lys Leu Ile Ser 
545                 550                 555                 560 


Glu Ser Ser Gly Glu Lys Ser Phe Glu Val Ser Glu Met Tyr Ile Phe 
                565                 570                 575     


Gly Lys Phe Glu Ala Phe Cys Lys Arg Leu Glu Lys Ile Thr Glu Met 
            580                 585                 590         


Ile Thr Val Val Gln Thr Tyr Ser Thr Leu Ser Asn Ser Thr Ile Glu 
        595                 600                 605             


Gly Ile Asp Ile Met Ala Ile Lys Phe Arg Asn Ile Tyr Gln Gly Val 
    610                 615                 620                 


Lys Lys Lys Gln Tyr Asp Ile Leu Asp Pro Arg Arg Thr Glu Phe Asp 
625                 630                 635                 640 


Thr Asp Phe Leu Asp Phe Met Thr Lys Ile Asn Gly Leu Glu Val Gln 
                645                 650                 655     


Ile Gln Ala Phe Met Asn Ser Ser Phe Gly Lys Ile Leu Ser Ser Gln 
            660                 665                 670         


Gln Ala Leu Gln Leu Leu Gln Arg Phe Gln Lys Leu Asn Ile Pro Cys 
        675                 680                 685             


Leu Gly Leu Glu Ile Asn His Thr Ile Glu Arg Ile Leu Gln Tyr Tyr 
    690                 695                 700                 


Val Ala Glu Leu Asp Ala Thr Lys Lys Leu Tyr His Ser Gln Lys Asp 
705                 710                 715                 720 


Asp Pro Pro Leu Ala Arg Asn Met Pro Pro Ile Ala Gly Lys Ile Leu 
                725                 730                 735     


Trp Val Arg Gln Leu Tyr Arg Arg Ile Ser Glu Pro Ile Asn Tyr Phe 
            740                 745                 750         


Phe Lys Asn Ser Asp Ile Leu Ser Ser Pro Asp Gly Lys Ala Val Ile 
        755                 760                 765             


Arg Gln Tyr Asn Lys Ile Ser Tyr Val Leu Val Glu Phe Glu Val Val 
    770                 775                 780                 


Tyr His Thr Ala Trp Ile Arg Glu Ile Ser Gln Leu His Tyr Ala Leu 
785                 790                 795                 800 


Gln Ala Thr Leu Phe Val Arg His Pro Glu Thr Gly Lys Leu Leu Val 
                805                 810                 815     


Asn Phe Asp Pro Lys Ile Leu Glu Val Val Arg Glu Thr Lys Cys Met 
            820                 825                 830         


Ile Lys Met Lys Leu Asp Val Pro Glu Gln Ala Lys Arg Leu Leu Lys 
        835                 840                 845             


Leu Glu Ser Lys Leu Lys Ala Asp Lys Leu Tyr Leu Gln Gly Leu Leu 
    850                 855                 860                 


Gln Tyr Tyr Asp Glu Leu Cys Gln Glu Val Pro Ser Val Phe Val Asn 
865                 870                 875                 880 


Leu Met Thr Pro Lys Met Lys Lys Val Glu Ser Val Leu Arg Gln Gly 
                885                 890                 895     


Leu Thr Val Leu Thr Trp Ser Ser Leu Thr Leu Glu Ser Phe Phe Gln 
            900                 905                 910         


Glu Val Glu Leu Val Leu Asp Met Phe Asn Gln Leu Leu Lys Lys Ile 
        915                 920                 925             


Ser Asp Leu Cys Glu Met His Ile Asp Thr Val Leu Lys Glu Ile Ala 
    930                 935                 940                 


Lys Thr Val Leu Ile Ser Leu Pro Glu Ser Gly Ala Thr Lys Val Glu 
945                 950                 955                 960 


Asp Met Leu Thr Leu Asn Glu Thr Tyr Thr Lys Glu Trp Ala Asp Ile 
                965                 970                 975     


Leu Asn His Lys Ser Lys His Val Glu Glu Ala Val Arg Glu Leu Ile 
            980                 985                 990         


Ser Ile Phe Glu Gln Ile Tyr Glu  Val Lys Tyr Thr Gly  Lys Val Gly 
        995                 1000                 1005             


Lys Gln  Ser Glu Gln Arg Lys  His Val Val Phe Gly  Ser Glu Thr 
    1010                 1015                 1020             


Gly Glu  Gly Glu Asn Asn Asp  Tyr Glu Ala Asn Ile  Val Asn Glu 
    1025                 1030                 1035             


Phe Asp  Thr His Asp Lys Glu  Asp Glu Phe Lys Lys  Glu Cys Lys 
    1040                 1045                 1050             


Glu Val  Phe Ala Phe Phe Ser  His Gln Leu Leu Asp  Ser Leu Gln 
    1055                 1060                 1065             


Lys Ala  Thr Arg Leu Ser Leu  Asp Thr Met Lys Arg  Arg Ile Phe 
    1070                 1075                 1080             


Val Ala  Ser Leu Tyr Gly Arg  Lys Gln Ser Glu Asp  Ile Ile Ser 
    1085                 1090                 1095             


Phe Ile  Lys Ser Glu Val His  Leu Ala Ile Pro Asn  Val Val Met 
    1100                 1105                 1110             


Ile Pro  Ser Leu Asp Asp Ile  Gln Gln Ala Ile Asn  Arg Met Ile 
    1115                 1120                 1125             


Gln Leu  Thr Leu Glu Val Ser  Arg Gly Val Ala His  Trp Gly Gln 
    1130                 1135                 1140             


Gln Gln  Ile Arg Pro Ile Lys  Ser Val Ile Pro Ser  Pro Thr Thr 
    1145                 1150                 1155             


Thr Asp  Val Thr His Gln Asn  Thr Gly Lys Leu Leu  Lys Lys Glu 
    1160                 1165                 1170             


Glu Arg  Ser Phe Glu Glu Ala  Ile Pro Ala Arg Lys  Leu Lys Asn 
    1175                 1180                 1185             


Phe Tyr  Pro Gly Val Ala Glu  His Lys Asp Ile Ser  Lys Leu Val 
    1190                 1195                 1200             


Leu Leu  Leu Ser Ser Ser Val  Asn Ser Leu Arg Lys  Ala Ala His 
    1205                 1210                 1215             


Glu Ala  Leu Gln Asp Phe Gln  Lys Tyr Lys Thr Leu  Trp Thr Glu 
    1220                 1225                 1230             


Asp Arg  Asp Val Lys Val Lys  Glu Phe Leu Ala Asn  Asn Pro Ser 
    1235                 1240                 1245             


Leu Thr  Glu Ile Arg Ser Glu  Ile Leu His Tyr Ala  Thr Phe Glu 
    1250                 1255                 1260             


Gln Glu  Ile Asp Glu Leu Lys  Pro Ile Ile Val Val  Gly Ala Leu 
    1265                 1270                 1275             


Glu Leu  His Thr Glu Pro Met  Lys Leu Ala Leu Ser  Ile Glu Ala 
    1280                 1285                 1290             


Lys Ala  Trp Lys Met Leu Leu  Cys Arg Tyr Leu Asn  Glu Glu Tyr 
    1295                 1300                 1305             


Lys Lys  Lys Met Ser Tyr Met  Ile Ala Phe Ile Asn  Glu Tyr Leu 
    1310                 1315                 1320             


Lys Lys  Leu Ser Arg Pro Ile  Arg Asp Leu Asp Asp  Val Arg Phe 
    1325                 1330                 1335             


Ala Met  Glu Ala Leu Ser Cys  Ile Arg Asp Asn Glu  Ile Gln Met 
    1340                 1345                 1350             


Asp Met  Thr Leu Gly Pro Ile  Glu Glu Ala Tyr Ala  Ile Leu Asn 
    1355                 1360                 1365             


Arg Phe  Glu Val Glu Val Thr  Lys Glu Glu Ser Glu  Ala Val Asp 
    1370                 1375                 1380             


Thr Leu  Arg Tyr Ser Phe Asn  Lys Leu Gln Ser Lys  Ala Val Ser 
    1385                 1390                 1395             


Val Gln  Glu Asp Leu Val Gln  Val Gln Pro Lys Phe  Lys Ser Asn 
    1400                 1405                 1410             


Leu Leu  Glu Ser Val Glu Val  Phe Arg Glu Asp Val  Ile Asn Phe 
    1415                 1420                 1425             


Ala Glu  Ala Tyr Glu Leu Glu  Gly Pro Met Val Pro  Asn Ile Pro 
    1430                 1435                 1440             


Pro Gln  Glu Ala Ser Asn Arg  Leu Gln Ile Phe Gln  Ala Ser Phe 
    1445                 1450                 1455             


Asp Asp  Leu Trp Arg Lys Phe  Val Thr Tyr Ser Ser  Gly Glu Gln 
    1460                 1465                 1470             


Leu Phe  Gly Leu Pro Val Thr  Asp Tyr Glu Val Leu  His Lys Thr 
    1475                 1480                 1485             


Arg Lys  Glu Leu Asn Leu Leu  Gln Lys Leu Tyr Gly  Leu Tyr Asp 
    1490                 1495                 1500             


Thr Val  Met Ser Ser Ile Ser  Gly Tyr Tyr Glu Ile  Leu Trp Gly 
    1505                 1510                 1515             


Asp Val  Asp Ile Glu Lys Ile  Asn Ala Glu Leu Leu  Glu Phe Gln 
    1520                 1525                 1530             


Asn Arg  Cys Arg Lys Leu Pro  Lys Gly Leu Lys Asp  Trp Gln Ala 
    1535                 1540                 1545             


Phe Leu  Asp Leu Lys Lys Arg  Ile Asp Asp Phe Ser  Glu Ser Cys 
    1550                 1555                 1560             


Pro Leu  Leu Glu Met Met Thr  Asn Lys Ala Met Lys  Gln Arg His 
    1565                 1570                 1575             


Trp Asp  Arg Ile Ser Glu Leu  Thr Gly Thr Pro Phe  Asp Val Glu 
    1580                 1585                 1590             


Ser Asp  Ser Phe Cys Leu Arg  Asn Ile Met Glu Ala  Pro Leu Leu 
    1595                 1600                 1605             


Lys His  Lys Asp Asp Ile Glu  Asp Ile Cys Ile Ser  Ala Ile Lys 
    1610                 1615                 1620             


Glu Lys  Asp Ile Glu Ala Lys  Leu Thr Gln Val Ile  Glu Asn Trp 
    1625                 1630                 1635             


Thr Asn  Gln Asn Leu Ser Phe  Ala Ala Phe Lys Gly  Lys Gly Glu 
    1640                 1645                 1650             


Leu Leu  Leu Lys Gly Thr Glu  Ser Gly Glu Ile Ile  Thr Leu Met 
    1655                 1660                 1665             


Glu Asp  Ser Leu Met Val Leu  Gly Ser Leu Leu Ser  Asn Arg Tyr 
    1670                 1675                 1680             


Asn Ala  Pro Phe Lys Lys Asn  Ile Gln Asn Trp Val  Tyr Lys Leu 
    1685                 1690                 1695             


Ser Thr  Ser Ser Asp Ile Ile  Glu Glu Trp Leu Val  Val Gln Asn 
    1700                 1705                 1710             


Leu Trp  Val Tyr Leu Glu Ala  Val Phe Val Gly Gly  Asp Ile Ala 
    1715                 1720                 1725             


Lys Gln  Leu Pro Gln Glu Ala  Lys Arg Phe Gln Asn  Ile Asp Lys 
    1730                 1735                 1740             


Ser Trp  Ile Lys Ile Met Gln  Arg Ala His Glu Asn  Pro Asn Val 
    1745                 1750                 1755             


Ile Asn  Cys Cys Val Gly Asp  Glu Thr Met Gly Gln  Leu Leu Pro 
    1760                 1765                 1770             


His Leu  His Glu Gln Leu Glu  Val Cys Gln Lys Ser  Leu Thr Gly 
    1775                 1780                 1785             


Tyr Leu  Glu Lys Lys Arg Leu  Leu Phe Pro Arg Phe  Phe Phe Val 
    1790                 1795                 1800             


Ser Asp  Pro Val Leu Leu Glu  Ile Leu Gly Gln Ala  Ser Asp Ser 
    1805                 1810                 1815             


His Thr  Ile Gln Pro His Leu  Pro Ala Val Ser Asp  Asn Ile Asn 
    1820                 1825                 1830             


Glu Val  Thr Phe His Ala Lys  Asp Tyr Asp Arg Ile  Met Ala Val 
    1835                 1840                 1845             


Ile Ser  Arg Glu Gly Glu Lys  Ile Val Leu Asp Asn  Ser Val Met 
    1850                 1855                 1860             


Ala Lys  Gly Pro Val Glu Ile  Trp Leu Leu Asp Leu  Leu Lys Met 
    1865                 1870                 1875             


Gln Met  Ser Ser Leu His Asn  Ile Ile Arg Ser Ala  Phe Tyr Gln 
    1880                 1885                 1890             


Ile Ser  Asp Ser Gly Phe Gln  Leu Leu Pro Phe Leu  Ser His Phe 
    1895                 1900                 1905             


Pro Ala  Gln Val Gly Leu Leu  Gly Ile Gln Met Leu  Trp Thr His 
    1910                 1915                 1920             


Asp Ser  Glu Glu Ala Leu Arg  Asn Ala Lys Asp Asp  Arg Lys Ile 
    1925                 1930                 1935             


Met Gln  Val Thr Asn Gln Lys  Phe Leu Asp Ile Leu  Asn Thr Leu 
    1940                 1945                 1950             


Ile Ser  Gln Thr Thr His Asp  Leu Ser Lys Phe Asp  Arg Val Lys 
    1955                 1960                 1965             


Phe Glu  Thr Leu Ile Thr Ile  His Val His Gln Arg  Asp Ile Phe 
    1970                 1975                 1980             


Asp Asp  Leu Val Lys Met His  Ile Lys Ser Pro Thr  Asp Phe Glu 
    1985                 1990                 1995             


Trp Leu  Lys Gln Ser Arg Phe  Tyr Phe Lys Glu Asp  Leu Asp Gln 
    2000                 2005                 2010             


Thr Val  Val Ser Ile Thr Asp  Val Asp Phe Ile Tyr  Gln Asn Glu 
    2015                 2020                 2025             


Phe Leu  Gly Cys Thr Asp Arg  Leu Val Ile Thr Pro  Leu Thr Asp 
    2030                 2035                 2040             


Arg Cys  Tyr Ile Thr Leu Ala  Gln Ala Leu Gly Met  Asn Met Gly 
    2045                 2050                 2055             


Gly Ala  Pro Ala Gly Pro Ala  Gly Thr Gly Lys Thr  Glu Thr Thr 
    2060                 2065                 2070             


Lys Asp  Met Gly Arg Cys Leu  Gly Lys Tyr Val Val  Val Phe Asn 
    2075                 2080                 2085             


Cys Ser  Asp Gln Met Asp Phe  Arg Gly Leu Gly Arg  Ile Phe Lys 
    2090                 2095                 2100             


Gly Leu  Ala Gln Ser Gly Ser  Trp Gly Cys Phe Asp  Glu Phe Asn 
    2105                 2110                 2115             


Arg Ile  Glu Leu Pro Val Leu  Ser Val Ala Ala Gln  Gln Ile Tyr 
    2120                 2125                 2130             


Ile Val  Leu Thr Ala Arg Lys  Glu Arg Lys Lys Gln  Phe Ile Phe 
    2135                 2140                 2145             


Ser Asp  Gly Asp Cys Val Asp  Leu Asn Pro Glu Phe  Gly Ile Phe 
    2150                 2155                 2160             


Leu Thr  Met Asn Pro Gly Tyr  Ala Gly Arg Gln Glu  Leu Pro Glu 
    2165                 2170                 2175             


Asn Leu  Lys Ile Gln Phe Arg  Thr Val Ala Met Met  Val Pro Asp 
    2180                 2185                 2190             


Arg Gln  Ile Ile Met Arg Val  Lys Leu Ala Ser Cys  Gly Phe Leu 
    2195                 2200                 2205             


Glu Asn  Val Ile Leu Ala Gln  Lys Phe Tyr Val Leu  Tyr Lys Leu 
    2210                 2215                 2220             


Cys Glu  Glu Gln Leu Thr Lys  Gln Val His Tyr Asp  Phe Gly Leu 
    2225                 2230                 2235             


Arg Asn  Ile Leu Ser Val Leu  Arg Thr Leu Gly Ser  Gln Lys Arg 
    2240                 2245                 2250             


Ala Arg  Pro Glu Asp Ser Glu  Leu Ser Ile Val Met  Arg Gly Leu 
    2255                 2260                 2265             


Arg Asp  Met Asn Leu Ser Lys  Leu Val Asp Glu Asp  Glu Pro Leu 
    2270                 2275                 2280             


Phe Leu  Ser Leu Ile Asn Asp  Leu Phe Pro Gly Leu  Gln Leu Asp 
    2285                 2290                 2295             


Ser Asn  Thr Tyr Ala Glu Leu  Gln Asn Ala Val Ala  His Gln Val 
    2300                 2305                 2310             


Gln Ile  Glu Gly Leu Ile Asn  His Pro Pro Trp Asn  Leu Lys Leu 
    2315                 2320                 2325             


Val Gln  Leu Tyr Glu Thr Ser  Leu Val Arg His Gly  Leu Met Thr 
    2330                 2335                 2340             


Leu Gly  Pro Ser Gly Ser Gly  Lys Thr Thr Val Ile  Thr Ile Leu 
    2345                 2350                 2355             


Met Lys  Ala Gln Thr Glu Cys  Gly Arg Pro His Arg  Glu Met Arg 
    2360                 2365                 2370             


Met Asn  Pro Lys Ala Ile Thr  Ala Pro Gln Met Phe  Gly Arg Leu 
    2375                 2380                 2385             


Asp Thr  Ala Thr Asn Asp Trp  Thr Asp Gly Ile Phe  Ser Thr Leu 
    2390                 2395                 2400             


Trp Arg  Lys Thr Leu Lys Ala  Lys Lys Gly Glu Asn  Ile Phe Leu 
    2405                 2410                 2415             


Ile Leu  Asp Gly Pro Val Asp  Ala Ile Trp Ile Glu  Asn Leu Asn 
    2420                 2425                 2430             


Ser Val  Leu Asp Asp Asn Lys  Thr Leu Thr Leu Ala  Asn Gly Asp 
    2435                 2440                 2445             


Arg Ile  Pro Met Ala Pro Ser  Cys Lys Leu Leu Phe  Glu Val His 
    2450                 2455                 2460             


Asn Ile  Glu Asn Ala Ser Pro  Ala Thr Val Ser Arg  Met Gly Met 
    2465                 2470                 2475             


Val Tyr  Ile Ser Ser Ser Ala  Leu Ser Trp Arg Pro  Ile Leu Gln 
    2480                 2485                 2490             


Ala Trp  Leu Lys Lys Arg Thr  Ala Gln Glu Ala Ala  Val Phe Leu 
    2495                 2500                 2505             


Thr Leu  Tyr Glu Lys Val Phe  Glu Asp Thr Tyr Thr  Tyr Met Lys 
    2510                 2515                 2520             


Leu Asn  Leu Asn Pro Lys Met  Gln Leu Leu Glu Cys  Asn Tyr Ile 
    2525                 2530                 2535             


Val Gln  Ser Leu Asn Leu Leu  Glu Gly Leu Ile Pro  Ser Lys Glu 
    2540                 2545                 2550             


Glu Gly  Gly Val Ser Cys Val  Glu His Leu His Lys  Leu Phe Val 
    2555                 2560                 2565             


Phe Gly  Leu Met Trp Ser Leu  Gly Ala Leu Leu Glu  Leu Glu Ser 
    2570                 2575                 2580             


Arg Glu  Lys Leu Glu Ala Phe  Leu Arg Gln His Glu  Ser Lys Leu 
    2585                 2590                 2595             


Asp Leu  Pro Glu Ile Pro Lys  Gly Ser Asn Gln Thr  Met Tyr Glu 
    2600                 2605                 2610             


Phe Tyr  Val Thr Asp Tyr Gly  Asp Trp Glu His Trp  Asn Lys Lys 
    2615                 2620                 2625             


Leu Gln  Pro Tyr Tyr Tyr Pro  Thr Asp Ser Ile Pro  Glu Tyr Ser 
    2630                 2635                 2640             


Ser Ile  Leu Val Pro Asn Val  Asp Asn Ile Arg Thr  Asn Phe Leu 
    2645                 2650                 2655             


Ile Asp  Thr Ile Ala Lys Gln  His Lys Ala Val Leu  Leu Thr Gly 
    2660                 2665                 2670             


Glu Gln  Gly Thr Ala Lys Thr  Val Met Val Lys Ala  Tyr Leu Lys 
    2675                 2680                 2685             


Lys Tyr  Asp Pro Glu Val Gln  Leu Ser Lys Ser Leu  Asn Phe Ser 
    2690                 2695                 2700             


Ser Ala  Thr Glu Pro Met Met  Phe Gln Arg Thr Ile  Glu Ser Tyr 
    2705                 2710                 2715             


Val Asp  Lys Arg Ile Gly Ser  Thr Tyr Gly Pro Pro  Gly Gly Arg 
    2720                 2725                 2730             


Lys Met  Thr Val Phe Ile Asp  Asp Ile Asn Met Pro  Val Ile Asn 
    2735                 2740                 2745             


Glu Trp  Gly Asp Gln Ile Thr  Asn Glu Ile Val Arg  Gln Met Met 
    2750                 2755                 2760             


Glu Met  Glu Gly Met Tyr Ser  Leu Asp Lys Pro Gly  Asp Phe Thr 
    2765                 2770                 2775             


Thr Ile  Val Asp Val Gln Leu  Ile Ala Ala Met Ile  His Pro Gly 
    2780                 2785                 2790             


Gly Gly  Arg Asn Asp Ile Pro  Gln Arg Leu Lys Arg  Gln Phe Thr 
    2795                 2800                 2805             


Val Phe  Asn Cys Thr Leu Pro  Ser Asn Ala Ser Ile  Asp Lys Ile 
    2810                 2815                 2820             


Phe Gly  Ile Ile Gly Cys Gly  Tyr Phe Asp Pro Cys  Arg Ser Phe 
    2825                 2830                 2835             


Lys Pro  Gln Ile Cys Glu Met  Ile Val Asn Leu Val  Ser Val Gly 
    2840                 2845                 2850             


Arg Val  Leu Trp Gln Trp Thr  Lys Val Lys Met Leu  Pro Thr Pro 
    2855                 2860                 2865             


Ser Lys  Phe His Tyr Ile Phe  Asn Leu Arg Asp Leu  Ser Arg Ile 
    2870                 2875                 2880             


Trp Gln  Gly Met Leu Thr Ile  Lys Ala Glu Glu Cys  Ala Ser Ile 
    2885                 2890                 2895             


Pro Thr  Leu Leu Ser Leu Phe  Lys His Glu Cys Ser  Arg Val Ile 
    2900                 2905                 2910             


Ala Asp  Arg Phe Ile Thr Pro  Glu Asp Glu Gln Trp  Phe Asn Ala 
    2915                 2920                 2925             


His Leu  Thr Arg Ala Val Glu  Glu Asn Ile Gly Ser  Asp Ala Ala 
    2930                 2935                 2940             


Ser Cys  Ile Leu Pro Glu Pro  Tyr Phe Val Asp Phe  Leu Arg Glu 
    2945                 2950                 2955             


Met Pro  Glu Pro Thr Gly Asp  Glu Pro Glu Asp Ser  Val Phe Glu 
    2960                 2965                 2970             


Val Pro  Lys Ile Tyr Glu Leu  Met Pro Ser Phe Asp  Phe Leu Ala 
    2975                 2980                 2985             


Glu Lys  Leu Gln Phe Tyr Gln  Arg Gln Phe Asn Glu  Ile Ile Arg 
    2990                 2995                 3000             


Gly Thr  Ser Leu Asp Leu Val  Phe Phe Lys Asp Ala  Met Thr His 
    3005                 3010                 3015             


Leu Ile  Lys Ile Ser Arg Ile  Ile Arg Thr Ser Cys  Gly Asn Ala 
    3020                 3025                 3030             


Leu Leu  Val Gly Val Gly Gly  Ser Gly Lys Gln Ser  Leu Ser Arg 
    3035                 3040                 3045             


Leu Ala  Ser Phe Ile Ala Gly  Tyr Gln Ile Phe Gln  Ile Thr Leu 
    3050                 3055                 3060             


Thr Arg  Ser Tyr Asn Val Thr  Asn Leu Thr Asp Asp  Leu Lys Ala 
    3065                 3070                 3075             


Leu Tyr  Lys Val Ala Gly Ala  Asp Gly Lys Gly Ile  Thr Phe Ile 
    3080                 3085                 3090             


Phe Thr  Asp Ser Glu Ile Lys  Asp Glu Ala Phe Leu  Glu Tyr Leu 
    3095                 3100                 3105             


Asn Asn  Leu Leu Ser Ser Gly  Glu Ile Ser Asn Leu  Phe Ala Arg 
    3110                 3115                 3120             


Asp Glu  Met Asp Glu Ile Thr  Gln Gly Leu Ile Ser  Val Met Lys 
    3125                 3130                 3135             


Arg Glu  Leu Pro Arg His Pro  Pro Thr Phe Asp Asn  Leu Tyr Glu 
    3140                 3145                 3150             


Tyr Phe  Ile Ser Arg Ser Arg  Lys Asn Leu His Val  Val Leu Cys 
    3155                 3160                 3165             


Phe Ser  Pro Val Gly Glu Lys  Phe Arg Ala Arg Ser  Leu Lys Phe 
    3170                 3175                 3180             


Pro Gly  Leu Ile Ser Gly Cys  Thr Met Asp Trp Phe  Ser Arg Trp 
    3185                 3190                 3195             


Pro Arg  Glu Ala Leu Ile Ala  Val Ala Ser Tyr Phe  Leu Ser Asp 
    3200                 3205                 3210             


Tyr Asn  Ile Val Cys Ser Ser  Glu Ile Lys Arg Gln  Val Val Glu 
    3215                 3220                 3225             


Thr Met  Gly Leu Phe His Asp  Met Val Ser Glu Ser  Cys Glu Ser 
    3230                 3235                 3240             


Tyr Phe  Gln Arg Tyr Arg Arg  Arg Ala His Val Thr  Pro Lys Ser 
    3245                 3250                 3255             


Tyr Leu  Ser Phe Ile Asn Gly  Tyr Lys Asn Ile Tyr  Ala Glu Lys 
    3260                 3265                 3270             


Val Lys  Phe Ile Asn Glu Gln  Ala Glu Arg Met Asn  Ile Gly Leu 
    3275                 3280                 3285             


Asp Lys  Leu Met Glu Ala Ser  Glu Ser Val Ala Lys  Leu Ser Gln 
    3290                 3295                 3300             


Asp Leu  Ala Val Lys Glu Lys  Glu Leu Ala Val Ala  Ser Ile Lys 
    3305                 3310                 3315             


Ala Asp  Glu Val Leu Ala Glu  Val Thr Val Ser Ala  Gln Ala Ser 
    3320                 3325                 3330             


Ala Lys  Ile Lys Asn Glu Val  Gln Glu Val Lys Asp  Lys Ala Gln 
    3335                 3340                 3345             


Lys Ile  Val Asp Glu Ile Asp  Ser Glu Lys Val Lys  Ala Glu Ser 
    3350                 3355                 3360             


Lys Leu  Glu Ala Ala Lys Pro  Ala Leu Glu Glu Ala  Glu Ala Ala 
    3365                 3370                 3375             


Leu Asn  Thr Ile Lys Pro Asn  Asp Ile Ala Thr Val  Arg Lys Leu 
    3380                 3385                 3390             


Ala Lys  Pro Pro His Leu Ile  Met Arg Ile Met Asp  Cys Val Leu 
    3395                 3400                 3405             


Leu Leu  Phe Gln Lys Lys Ile  Asp Pro Val Thr Met  Asp Pro Glu 
    3410                 3415                 3420             


Lys Ser  Cys Cys Lys Pro Ser  Trp Gly Glu Ser Leu  Lys Leu Met 
    3425                 3430                 3435             


Ser Ala  Thr Gly Phe Leu Trp  Ser Leu Gln Gln Phe  Pro Lys Asp 
    3440                 3445                 3450             


Thr Ile  Asn Glu Glu Thr Val  Glu Leu Leu Gln Pro  Tyr Phe Asn 
    3455                 3460                 3465             


Met Asp  Asp Tyr Thr Phe Glu  Ser Ala Lys Lys Val  Cys Gly Asn 
    3470                 3475                 3480             


Val Ala  Gly Leu Leu Ser Trp  Thr Leu Ala Met Ala  Ile Phe Tyr 
    3485                 3490                 3495             


Gly Ile  Asn Arg Glu Val Leu  Pro Leu Lys Ala Asn  Leu Ala Lys 
    3500                 3505                 3510             


Gln Glu  Gly Arg Leu Ala Val  Ala Asn Ala Glu Leu  Gly Lys Ala 
    3515                 3520                 3525             


Gln Ala  Leu Leu Asp Glu Lys  Gln Ala Glu Leu Asp  Lys Val Gln 
    3530                 3535                 3540             


Ala Lys  Phe Asp Ala Ala Met  Asn Glu Lys Met Asp  Leu Leu Asn 
    3545                 3550                 3555             


Asp Ala  Asp Thr Cys Arg Lys  Lys Met Gln Ala Ala  Ser Thr Leu 
    3560                 3565                 3570             


Ile Asp  Gly Leu Ser Gly Glu  Lys Ile Arg Trp Thr  Gln Gln Ser 
    3575                 3580                 3585             


Lys Glu  Phe Lys Ala Gln Ile  Asn Arg Leu Val Gly  Asp Ile Leu 
    3590                 3595                 3600             


Leu Cys  Thr Gly Phe Leu Ser  Tyr Leu Gly Pro Phe  Asn Gln Ile 
    3605                 3610                 3615             


Phe Arg  Asn Tyr Leu Leu Lys  Asp Gln Trp Glu Met  Glu Leu Arg 
    3620                 3625                 3630             


Ala Arg  Lys Ile Pro Phe Thr  Glu Asn Leu Asn Leu  Ile Ser Met 
    3635                 3640                 3645             


Leu Val  Asp Pro Pro Thr Ile  Gly Glu Trp Gly Leu  Gln Gly Leu 
    3650                 3655                 3660             


Pro Gly  Asp Asp Leu Ser Ile  Gln Asn Gly Ile Ile  Val Thr Lys 
    3665                 3670                 3675             


Ala Thr  Arg Tyr Pro Leu Leu  Ile Asp Pro Gln Thr  Gln Gly Lys 
    3680                 3685                 3690             


Thr Trp  Ile Lys Ser Lys Glu  Lys Glu Asn Asp Leu  Gln Val Thr 
    3695                 3700                 3705             


Ser Leu  Asn His Lys Tyr Phe  Arg Thr His Leu Glu  Asp Ser Leu 
    3710                 3715                 3720             


Ser Leu  Gly Arg Pro Leu Leu  Ile Glu Asp Ile His  Glu Glu Leu 
    3725                 3730                 3735             


Asp Pro  Ala Leu Asp Asn Val  Leu Glu Lys Asn Phe  Ile Lys Ser 
    3740                 3745                 3750             


Gly Thr  Thr Phe Lys Val Lys  Val Gly Asp Lys Glu  Cys Asp Ile 
    3755                 3760                 3765             


Met Asp  Thr Phe Lys Leu Tyr  Ile Thr Thr Lys Leu  Pro Asn Pro 
    3770                 3775                 3780             


Ala Phe  Thr Pro Glu Ile Asn  Ala Lys Thr Ser Val  Ile Asp Phe 
    3785                 3790                 3795             


Thr Val  Thr Met Lys Gly Leu  Glu Asn Gln Leu Leu  Arg Arg Val 
    3800                 3805                 3810             


Ile Leu  Thr Glu Lys Gln Glu  Leu Glu Ala Glu Arg  Val Lys Leu 
    3815                 3820                 3825             


Leu Glu  Asp Val Thr Phe Asn  Lys Arg Lys Met Lys  Glu Leu Glu 
    3830                 3835                 3840             


Asp Asn  Leu Leu Tyr Lys Leu  Ser Ala Thr Lys Gly  Ser Leu Val 
    3845                 3850                 3855             


Asp Asp  Glu Ser Leu Ile Gly  Val Leu Arg Thr Thr  Lys Gln Thr 
    3860                 3865                 3870             


Ala Ala  Glu Val Ser Glu Lys  Leu His Val Ala Ala  Glu Thr Glu 
    3875                 3880                 3885             


Ile Lys  Ile Asn Ala Ala Gln  Glu Glu Phe Arg Pro  Ala Ala Thr 
    3890                 3895                 3900             


Arg Gly  Ser Ile Leu Tyr Phe  Leu Ile Thr Glu Met  Ser Met Val 
    3905                 3910                 3915             


Asn Ile  Met Tyr Gln Thr Ser  Leu Ala Gln Phe Leu  Lys Leu Phe 
    3920                 3925                 3930             


Asp Gln  Ser Met Ala Arg Ser  Glu Lys Ser Pro Leu  Pro Gln Lys 
    3935                 3940                 3945             


Arg Ile  Thr Asn Ile Ile Glu  Tyr Leu Thr Tyr Glu  Val Phe Thr 
    3950                 3955                 3960             


Tyr Ser  Val Arg Gly Leu Tyr  Glu Asn His Lys Phe  Leu Phe Val 
    3965                 3970                 3975             


Leu Leu  Met Thr Leu Lys Ile  Asp Leu Gln Arg Gly  Thr Val Lys 
    3980                 3985                 3990             


His Arg  Glu Phe Gln Ala Leu  Ile Lys Gly Gly Ala  Ala Leu Asp 
    3995                 4000                 4005             


Leu Lys  Ala Cys Pro Pro Lys  Pro Tyr Arg Trp Ile  Leu Asp Met 
    4010                 4015                 4020             


Thr Trp  Leu Asn Leu Val Glu  Leu Ser Lys Leu Pro  Gln Phe Ala 
    4025                 4030                 4035             


Glu Ile  Met Asn Gln Ile Ser  Arg Asn Glu Lys Gly  Trp Lys Ser 
    4040                 4045                 4050             


Trp Phe  Asp Lys Asp Ala Pro  Glu Glu Glu Ile Ile  Pro Asp Gly 
    4055                 4060                 4065             


Tyr Asn  Asp Ser Leu Asp Thr  Cys His Lys Leu Leu  Leu Ile Arg 
    4070                 4075                 4080             


Ser Trp  Cys Pro Asp Arg Thr  Val Phe Gln Ala Arg  Lys Tyr Ile 
    4085                 4090                 4095             


Ala Asp  Ser Leu Glu Glu Lys  Tyr Thr Glu Pro Val  Ile Leu Asn 
    4100                 4105                 4110             


Leu Glu  Lys Thr Trp Glu Glu  Ser Asp Thr Arg Thr  Pro Leu Ile 
    4115                 4120                 4125             


Cys Phe  Leu Ser Met Gly Ser  Asp Pro Thr Asn Gln  Ile Asp Ala 
    4130                 4135                 4140             


Leu Ala  Lys Lys Leu Lys Leu  Glu Cys Arg Thr Ile  Ser Met Gly 
    4145                 4150                 4155             


Gln Gly  Gln Glu Val His Ala  Arg Lys Leu Ile Gln  Met Ser Met 
    4160                 4165                 4170             


Gln Gln  Gly Gly Trp Val Leu  Leu Gln Asn Cys His  Leu Gly Leu 
    4175                 4180                 4185             


Glu Phe  Met Glu Glu Leu Leu  Glu Thr Leu Ile Thr  Thr Glu Ala 
    4190                 4195                 4200             


Ser Asp  Asp Ser Phe Arg Val  Trp Ile Thr Thr Glu  Pro His Asp 
    4205                 4210                 4215             


Arg Phe  Pro Ile Thr Leu Leu  Gln Thr Ser Leu Lys  Phe Thr Asn 
    4220                 4225                 4230             


Glu Pro  Pro Gln Gly Val Arg  Ala Gly Leu Lys Arg  Thr Phe Ala 
    4235                 4240                 4245             


Gly Ile  Asn Gln Asp Leu Leu  Asp Ile Ser Asn Leu  Pro Met Trp 
    4250                 4255                 4260             


Lys Pro  Met Leu Tyr Thr Val  Ala Phe Leu His Ser  Thr Val Gln 
    4265                 4270                 4275             


Glu Arg  Arg Lys Phe Gly Pro  Leu Gly Trp Asn Ile  Pro Tyr Glu 
    4280                 4285                 4290             


Phe Asn  Ser Ala Asp Phe Ser  Ala Ser Val Gln Phe  Ile Gln Asn 
    4295                 4300                 4305             


His Leu  Asp Glu Cys Asp Ile  Lys Lys Gly Val Ser  Trp Asn Thr 
    4310                 4315                 4320             


Val Arg  Tyr Met Ile Gly Glu  Val Gln Tyr Gly Gly  Arg Val Thr 
    4325                 4330                 4335             


Asp Asp  Phe Asp Lys Arg Leu  Leu Asn Cys Phe Ala  Arg Val Trp 
    4340                 4345                 4350             


Phe Ser  Glu Lys Met Phe Glu  Pro Ser Phe Cys Phe  Tyr Thr Gly 
    4355                 4360                 4365             


Tyr Lys  Ile Pro Leu Cys Lys  Thr Leu Asp Gln Tyr  Phe Glu Tyr 
    4370                 4375                 4380             


Ile Gln  Ser Leu Pro Ser Leu  Asp Asn Pro Glu Val  Phe Gly Leu 
    4385                 4390                 4395             


His Pro  Asn Ala Asp Ile Thr  Tyr Gln Ser Asn Thr  Ala Ser Ala 
    4400                 4405                 4410             


Val Leu  Glu Thr Ile Thr Asn  Ile Gln Pro Lys Glu  Ser Gly Gly 
    4415                 4420                 4425             


Gly Val  Gly Glu Thr Arg Glu  Ala Ile Val Tyr Arg  Leu Ser Glu 
    4430                 4435                 4440             


Asp Met  Leu Ser Lys Leu Pro  Pro Asp Tyr Ile Pro  His Glu Val 
    4445                 4450                 4455             


Lys Ser  Arg Leu Ile Lys Met  Gly His Leu Asn Ser  Met Asn Ile 
    4460                 4465                 4470             


Phe Leu  Arg Gln Glu Ile Asp  Arg Met Gln Arg Val  Ile Ser Ile 
    4475                 4480                 4485             


Leu Arg  Ser Ser Leu Ser Asp  Leu Lys Leu Ala Ile  Glu Gly Thr 
    4490                 4495                 4500             


Ile Ile  Met Ser Glu Asn Leu  Arg Asp Ala Leu Asp  Asn Met Tyr 
    4505                 4510                 4515             


Asp Ala  Arg Ile Pro Gln Leu  Trp Lys Arg Val Ser  Trp Asp Ser 
    4520                 4525                 4530             


Ser Thr  Leu Gly Phe Trp Phe  Thr Glu Leu Leu Glu  Arg Asn Ala 
    4535                 4540                 4545             


Gln Phe  Ser Thr Trp Ile Phe  Glu Gly Arg Pro Asn  Val Phe Trp 
    4550                 4555                 4560             


Met Thr  Gly Phe Phe Asn Pro  Gln Gly Phe Leu Thr  Ala Met Arg 
    4565                 4570                 4575             


Gln Glu  Val Thr Arg Ala His  Lys Gly Trp Ala Leu  Asp Thr Val 
    4580                 4585                 4590             


Thr Ile  His Asn Glu Val Leu  Arg Gln Thr Lys Glu  Glu Ile Thr 
    4595                 4600                 4605             


Ser Pro  Pro Gly Glu Gly Val  Tyr Ile Tyr Gly Leu  Tyr Met Asp 
    4610                 4615                 4620             


Gly Ala  Ala Trp Asp Arg Arg  Asn Gly Lys Leu Met  Glu Ser Thr 
    4625                 4630                 4635             


Pro Lys  Val Leu Phe Thr Gln  Leu Pro Val Leu His  Ile Phe Ala 
    4640                 4645                 4650             


Ile Asn  Ser Thr Ala Pro Lys  Asp Pro Lys Leu Tyr  Val Cys Pro 
    4655                 4660                 4665             


Ile Tyr  Lys Lys Pro Arg Arg  Thr Asp Leu Thr Phe  Ile Thr Val 
    4670                 4675                 4680             


Val Tyr  Leu Arg Thr Val Leu  Ser Pro Asp His Trp  Ile Leu Arg 
    4685                 4690                 4695             


Gly Val  Ala Leu Leu Cys Asp  Ile Lys 
    4700                 4705         


<210>  3148
<211>  4486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAH9__Homo_sapiens__NP_001363

<400>  3148

Met Arg Leu Ala Glu Glu Arg Ala Ala Leu Ala Ala Glu Asn Ala Asp 
1               5                   10                  15      


Gly Glu Pro Gly Ala Asp Arg Arg Leu Arg Leu Leu Gly Thr Tyr Val 
            20                  25                  30          


Ala Met Ser Leu Arg Pro Ala Ala Gly Ala Trp Glu Arg Cys Ala Gly 
        35                  40                  45              


Ser Ala Glu Ala Glu Gln Leu Leu Gln Ala Phe Leu Gly Arg Asp Ala 
    50                  55                  60                  


Ala Glu Gly Pro Arg Pro Leu Leu Val Val Arg Pro Gly Pro Arg Gly 
65                  70                  75                  80  


Leu Ala Ile Arg Pro Gly Leu Glu Val Gly Pro Glu Ser Gly Leu Ala 
                85                  90                  95      


Gly Ala Lys Ala Leu Phe Phe Leu Arg Thr Gly Pro Glu Pro Pro Gly 
            100                 105                 110         


Pro Asp Ser Phe Arg Gly Ala Val Val Cys Gly Asp Leu Pro Ala Ala 
        115                 120                 125             


Pro Leu Glu His Leu Ala Ala Leu Phe Ser Glu Val Val Leu Pro Val 
    130                 135                 140                 


Leu Ala Asn Glu Lys Asn Arg Leu Asn Trp Pro His Met Ile Cys Glu 
145                 150                 155                 160 


Asp Val Arg Arg His Ala His Ser Leu Gln Cys Asp Leu Ser Val Ile 
                165                 170                 175     


Leu Glu Gln Val Lys Gly Lys Thr Leu Leu Pro Leu Pro Ala Gly Ser 
            180                 185                 190         


Glu Lys Met Glu Phe Ala Asp Ser Lys Ser Glu Thr Val Leu Asp Ser 
        195                 200                 205             


Ile Asp Lys Ser Val Ile Tyr Ala Ile Glu Ser Ala Val Ile Lys Trp 
    210                 215                 220                 


Ser Tyr Gln Val Gln Val Val Leu Lys Arg Glu Ser Ser Gln Pro Leu 
225                 230                 235                 240 


Leu Gln Gly Glu Asn Pro Thr Pro Lys Val Glu Leu Glu Phe Trp Lys 
                245                 250                 255     


Ser Arg Tyr Glu Asp Leu Lys Tyr Ile Tyr Asn Gln Leu Arg Thr Ile 
            260                 265                 270         


Thr Val Arg Gly Met Ala Lys Leu Leu Asp Lys Leu Gln Ser Ser Tyr 
        275                 280                 285             


Phe Pro Ala Phe Lys Ala Met Tyr Arg Asp Val Val Ala Ala Leu Ala 
    290                 295                 300                 


Glu Ala Gln Asp Ile His Val His Leu Ile Pro Leu Gln Arg His Leu 
305                 310                 315                 320 


Glu Ala Leu Glu Asn Ala Glu Phe Pro Glu Val Lys Pro Gln Leu Arg 
                325                 330                 335     


Pro Leu Leu His Val Val Cys Leu Ile Trp Ala Thr Cys Lys Ser Tyr 
            340                 345                 350         


Arg Ser Pro Gly Arg Leu Thr Val Leu Leu Gln Glu Ile Cys Asn Leu 
        355                 360                 365             


Leu Ile Gln Gln Ala Ser Asn Tyr Leu Ser Pro Glu Asp Leu Leu Arg 
    370                 375                 380                 


Ser Glu Val Glu Glu Ser Gln Arg Lys Leu Gln Val Val Ser Asp Thr 
385                 390                 395                 400 


Leu Ser Phe Phe Lys Gln Glu Phe Gln Asp Arg Arg Glu Asn Leu His 
                405                 410                 415     


Thr Tyr Phe Lys Glu Asn Gln Glu Val Lys Glu Trp Asp Phe Gln Ser 
            420                 425                 430         


Ser Leu Val Phe Val Arg Leu Asp Gly Phe Leu Gly Gln Leu His Val 
        435                 440                 445             


Val Glu Gly Leu Leu Lys Thr Ala Leu Asp Phe His Lys Leu Gly Lys 
    450                 455                 460                 


Val Glu Phe Ser Gly Val Arg Gly Asn Ala Leu Ser Gln Gln Val Gln 
465                 470                 475                 480 


Gln Met His Glu Glu Phe Gln Glu Met Tyr Arg Leu Leu Ser Gly Ser 
                485                 490                 495     


Ser Ser Asp Cys Leu Tyr Leu Gln Ser Thr Asp Phe Glu Asn Asp Val 
            500                 505                 510         


Ser Glu Phe Asn Gln Lys Val Glu Asp Leu Asp Arg Arg Leu Gly Thr 
        515                 520                 525             


Ile Phe Ile Gln Ala Phe Asp Asp Ala Pro Gly Leu Glu His Ala Phe 
    530                 535                 540                 


Lys Leu Leu Asp Ile Ala Gly Asn Leu Leu Glu Arg Pro Leu Val Ala 
545                 550                 555                 560 


Arg Asp Thr Ser Asp Lys Tyr Leu Val Leu Ile Gln Met Phe Asn Lys 
                565                 570                 575     


Asp Leu Asp Ala Val Arg Met Ile Tyr Ser Gln His Val Gln Glu Glu 
            580                 585                 590         


Ala Glu Leu Gly Phe Ser Pro Val His Lys Asn Met Pro Thr Val Ala 
        595                 600                 605             


Gly Gly Leu Arg Trp Ala Gln Glu Leu Arg Gln Arg Ile Gln Gly Pro 
    610                 615                 620                 


Phe Ser Asn Phe Gly Arg Ile Thr His Pro Cys Met Glu Ser Ala Glu 
625                 630                 635                 640 


Gly Lys Arg Met Gln Gln Lys Tyr Glu Asp Met Leu Ser Leu Leu Glu 
                645                 650                 655     


Lys Tyr Glu Thr Arg Leu Tyr Glu Asp Trp Cys Arg Thr Val Ser Glu 
            660                 665                 670         


Lys Ser Gln Tyr Asn Leu Ser Gln Pro Leu Leu Lys Arg Asp Pro Glu 
        675                 680                 685             


Thr Lys Glu Ile Thr Ile Asn Phe Asn Pro Gln Leu Ile Ser Val Leu 
    690                 695                 700                 


Lys Glu Met Ser Tyr Leu Glu Pro Arg Glu Met Lys His Met Pro Glu 
705                 710                 715                 720 


Thr Ala Ala Ala Met Phe Ser Ser Arg Asp Phe Tyr Arg Gln Leu Val 
                725                 730                 735     


Ala Asn Leu Glu Leu Met Ala Asn Trp Tyr Asn Lys Val Met Lys Thr 
            740                 745                 750         


Leu Leu Glu Val Glu Phe Pro Leu Val Glu Glu Glu Leu Gln Asn Ile 
        755                 760                 765             


Asp Leu Arg Leu Arg Ala Ala Glu Glu Thr Leu Asn Trp Lys Thr Glu 
    770                 775                 780                 


Gly Ile Cys Asp Tyr Val Thr Glu Ile Thr Ser Ser Ile His Asp Leu 
785                 790                 795                 800 


Glu Gln Arg Ile Gln Lys Thr Lys Asp Asn Val Glu Glu Ile Gln Asn 
                805                 810                 815     


Ile Met Lys Thr Trp Val Thr Pro Ile Phe Lys Thr Lys Asp Gly Lys 
            820                 825                 830         


Arg Glu Ser Leu Leu Ser Leu Asp Asp Arg His Asp Arg Met Glu Lys 
        835                 840                 845             


Tyr Tyr Asn Leu Ile Lys Glu Ser Gly Leu Lys Ile His Ala Leu Val 
    850                 855                 860                 


Gln Glu Asn Leu Gly Leu Phe Ser Ala Asp Pro Thr Ser Asn Ile Trp 
865                 870                 875                 880 


Lys Thr Tyr Val Asn Ser Ile Asp Asn Leu Leu Leu Asn Gly Phe Phe 
                885                 890                 895     


Leu Ala Ile Glu Cys Ser Leu Lys Tyr Leu Leu Glu Asn Thr Glu Cys 
            900                 905                 910         


Lys Ala Gly Leu Thr Pro Ile Phe Glu Ala Gln Leu Ser Leu Ala Ile 
        915                 920                 925             


Pro Glu Leu Val Phe Tyr Pro Ser Leu Glu Ser Gly Val Lys Gly Gly 
    930                 935                 940                 


Phe Cys Asp Ile Val Glu Gly Leu Ile Thr Ser Ile Phe Arg Ile Pro 
945                 950                 955                 960 


Ser Leu Val Pro Arg Leu Ser Pro Gln Asn Gly Ser Pro His Tyr Gln 
                965                 970                 975     


Val Asp Leu Asp Gly Ile Pro Asp Leu Ala Asn Met Arg Arg Thr Leu 
            980                 985                 990         


Met Glu Arg Val Gln Arg Met Met  Gly Leu Cys Cys Gly  Tyr Gln Ser 
        995                 1000                 1005             


Thr Phe  Ser Gln Tyr Ser Tyr  Leu Tyr Val Glu Asp  Arg Lys Glu 
    1010                 1015                 1020             


Val Leu  Gly Gln Phe Leu Leu  Tyr Gly His Ile Leu  Thr Pro Glu 
    1025                 1030                 1035             


Glu Ile  Glu Asp His Val Glu  Asp Gly Ile Pro Glu  Asn Pro Pro 
    1040                 1045                 1050             


Leu Leu  Ser Gln Phe Lys Val  Gln Ile Asp Ser Tyr  Glu Thr Leu 
    1055                 1060                 1065             


Tyr Glu  Glu Val Cys Arg Leu  Glu Pro Ile Lys Val  Phe Asp Gly 
    1070                 1075                 1080             


Trp Met  Lys Ile Asp Ile Arg  Pro Phe Lys Ala Ser  Leu Leu Asn 
    1085                 1090                 1095             


Ile Ile  Lys Arg Trp Ser Leu  Leu Phe Lys Gln His  Leu Val Asp 
    1100                 1105                 1110             


His Val  Thr His Ser Leu Ala  Asn Leu Asp Ala Phe  Ile Lys Lys 
    1115                 1120                 1125             


Ser Glu  Ser Gly Leu Leu Lys  Lys Val Glu Lys Gly  Asp Phe Gln 
    1130                 1135                 1140             


Gly Leu  Val Glu Ile Met Gly  His Leu Met Ala Val  Lys Glu Arg 
    1145                 1150                 1155             


Gln Ser  Asn Thr Asp Glu Met  Phe Glu Pro Leu Lys  Gln Thr Ile 
    1160                 1165                 1170             


Glu Leu  Leu Lys Thr Tyr Glu  Gln Glu Leu Pro Glu  Thr Val Phe 
    1175                 1180                 1185             


Lys Gln  Leu Glu Glu Leu Pro  Glu Lys Trp Asn Asn  Ile Lys Lys 
    1190                 1195                 1200             


Val Ala  Ile Thr Val Lys Gln  Gln Val Ala Pro Leu  Gln Ala Asn 
    1205                 1210                 1215             


Glu Val  Thr Leu Leu Arg Gln  Arg Cys Thr Ala Phe  Asp Ala Glu 
    1220                 1225                 1230             


Gln Gln  Gln Phe Trp Glu Gln  Phe His Lys Glu Ala  Pro Phe Arg 
    1235                 1240                 1245             


Phe Asp  Ser Ile His Pro His  Gln Met Leu Asp Ala  Arg His Ile 
    1250                 1255                 1260             


Glu Ile  Gln Gln Met Glu Ser  Thr Met Ala Ser Ile  Ser Glu Ser 
    1265                 1270                 1275             


Ala Ser  Leu Phe Glu Val Asn  Val Pro Asp Tyr Lys  Gln Leu Arg 
    1280                 1285                 1290             


Gln Cys  Arg Lys Glu Val Cys  Gln Leu Lys Glu Leu  Trp Asp Thr 
    1295                 1300                 1305             


Ile Gly  Met Val Thr Ser Ser  Ile His Ala Trp Glu  Thr Thr Pro 
    1310                 1315                 1320             


Trp Arg  Asn Ile Asn Val Glu  Ala Met Glu Leu Glu  Cys Lys Gln 
    1325                 1330                 1335             


Phe Ala  Arg His Ile Arg Asn  Leu Asp Lys Glu Val  Arg Ala Trp 
    1340                 1345                 1350             


Asp Ala  Phe Thr Gly Leu Glu  Ser Thr Val Trp Asn  Thr Leu Ser 
    1355                 1360                 1365             


Ser Leu  Arg Ala Val Ala Glu  Leu Gln Asn Pro Ala  Ile Arg Glu 
    1370                 1375                 1380             


Arg His  Trp Arg Gln Leu Met  Gln Ala Thr Gly Val  Ser Phe Thr 
    1385                 1390                 1395             


Met Asp  Gln Asp Thr Thr Leu  Ala His Leu Leu Gln  Leu Gln Leu 
    1400                 1405                 1410             


His His  Tyr Glu Asp Glu Val  Arg Gly Ile Val Asp  Lys Ala Ala 
    1415                 1420                 1425             


Lys Glu  Met Gly Met Glu Lys  Thr Leu Lys Glu Leu  Gln Thr Thr 
    1430                 1435                 1440             


Trp Ala  Gly Met Glu Phe Gln  Tyr Glu Pro His Pro  Arg Thr Asn 
    1445                 1450                 1455             


Val Pro  Leu Leu Cys Ser Asp  Glu Asp Leu Ile Glu  Val Leu Glu 
    1460                 1465                 1470             


Asp Asn  Gln Val Gln Leu Gln  Asn Leu Val Met Ser  Lys Tyr Val 
    1475                 1480                 1485             


Ala Phe  Phe Leu Glu Glu Val  Ser Gly Trp Gln Lys  Lys Leu Ser 
    1490                 1495                 1500             


Thr Val  Asp Ala Val Ile Ser  Ile Trp Phe Glu Val  Gln Arg Thr 
    1505                 1510                 1515             


Trp Thr  His Leu Glu Ser Ile  Phe Thr Gly Ser Glu  Asp Ile Arg 
    1520                 1525                 1530             


Ala Gln  Leu Pro Gln Asp Ser  Lys Arg Phe Glu Gly  Ile Asp Ile 
    1535                 1540                 1545             


Asp Phe  Lys Glu Leu Ala Tyr  Asp Ala Gln Lys Ile  Pro Asn Val 
    1550                 1555                 1560             


Val Gln  Thr Thr Asn Lys Pro  Gly Leu Tyr Glu Lys  Leu Glu Asp 
    1565                 1570                 1575             


Ile Gln  Gly Arg Leu Cys Leu  Cys Glu Lys Ala Leu  Ala Glu Tyr 
    1580                 1585                 1590             


Leu Asp  Thr Lys Arg Leu Ala  Phe Pro Arg Phe Tyr  Phe Leu Ser 
    1595                 1600                 1605             


Ser Ser  Asp Leu Leu Asp Ile  Leu Ser Asn Gly Thr  Ala Pro Gln 
    1610                 1615                 1620             


Gln Val  Gln Arg His Leu Ser  Lys Leu Phe Asp Asn  Met Ala Lys 
    1625                 1630                 1635             


Met Arg  Phe Gln Leu Asp Ala  Ser Gly Glu Pro Thr  Lys Thr Ser 
    1640                 1645                 1650             


Leu Gly  Met Tyr Ser Lys Glu  Glu Glu Tyr Val Ala  Phe Ser Glu 
    1655                 1660                 1665             


Pro Cys  Asp Cys Ser Gly Gln  Val Glu Ile Trp Leu  Asn His Val 
    1670                 1675                 1680             


Leu Gly  His Met Lys Ala Thr  Val Arg His Glu Met  Thr Glu Gly 
    1685                 1690                 1695             


Val Thr  Ala Tyr Glu Glu Lys  Pro Arg Glu Gln Trp  Leu Phe Asp 
    1700                 1705                 1710             


His Pro  Ala Gln Val Ala Leu  Thr Cys Thr Gln Ile  Trp Trp Thr 
    1715                 1720                 1725             


Thr Glu  Val Gly Met Ala Phe  Ala Arg Leu Glu Glu  Gly Tyr Glu 
    1730                 1735                 1740             


Ser Ala  Met Lys Asp Tyr Tyr  Lys Lys Gln Val Ala  Gln Leu Lys 
    1745                 1750                 1755             


Thr Leu  Ile Thr Met Leu Ile  Gly Gln Leu Ser Lys  Gly Asp Arg 
    1760                 1765                 1770             


Gln Lys  Ile Met Thr Ile Cys  Thr Ile Asp Val His  Ala Arg Asp 
    1775                 1780                 1785             


Val Val  Ala Lys Met Ile Ala  Gln Lys Val Asp Asn  Ala Gln Ala 
    1790                 1795                 1800             


Phe Leu  Trp Leu Ser Gln Leu  Arg His Arg Trp Asp  Asp Glu Val 
    1805                 1810                 1815             


Lys His  Cys Phe Ala Asn Ile  Cys Asp Ala Gln Phe  Leu Tyr Ser 
    1820                 1825                 1830             


Tyr Glu  Tyr Leu Gly Asn Thr  Pro Arg Leu Val Ile  Thr Pro Leu 
    1835                 1840                 1845             


Thr Asp  Arg Cys Tyr Ile Thr  Leu Thr Gln Ser Leu  His Leu Thr 
    1850                 1855                 1860             


Met Ser  Gly Ala Pro Ala Gly  Pro Ala Gly Thr Gly  Lys Thr Glu 
    1865                 1870                 1875             


Thr Thr  Lys Asp Leu Gly Arg  Ala Leu Gly Ile Leu  Val Tyr Val 
    1880                 1885                 1890             


Phe Asn  Cys Ser Glu Gln Met  Asp Tyr Lys Ser Cys  Gly Asn Ile 
    1895                 1900                 1905             


Tyr Lys  Gly Leu Ala Gln Thr  Gly Ala Trp Gly Cys  Phe Asp Glu 
    1910                 1915                 1920             


Phe Asn  Arg Ile Ser Val Glu  Val Leu Ser Val Val  Ala Val Gln 
    1925                 1930                 1935             


Val Lys  Ser Ile Gln Asp Ala  Ile Arg Asp Lys Lys  Gln Trp Phe 
    1940                 1945                 1950             


Ser Phe  Leu Gly Glu Glu Ile  Ser Leu Asn Pro Ser  Val Gly Ile 
    1955                 1960                 1965             


Phe Ile  Thr Met Asn Pro Gly  Tyr Ala Gly Arg Thr  Glu Leu Pro 
    1970                 1975                 1980             


Glu Asn  Leu Lys Ser Leu Phe  Arg Pro Cys Ala Met  Val Val Pro 
    1985                 1990                 1995             


Asp Phe  Glu Leu Ile Cys Glu  Ile Met Leu Val Ala  Glu Gly Phe 
    2000                 2005                 2010             


Ile Glu  Ala Gln Ser Leu Ala  Arg Lys Phe Ile Thr  Leu Tyr Gln 
    2015                 2020                 2025             


Leu Cys  Lys Glu Leu Leu Ser  Lys Gln Asp His Tyr  Asp Trp Gly 
    2030                 2035                 2040             


Leu Arg  Ala Ile Lys Ser Val  Leu Val Val Ala Gly  Ser Leu Lys 
    2045                 2050                 2055             


Arg Gly  Asp Pro Asp Arg Pro  Glu Asp Gln Val Leu  Met Arg Ser 
    2060                 2065                 2070             


Leu Arg  Asp Phe Asn Ile Pro  Lys Ile Val Thr Asp  Asp Met Pro 
    2075                 2080                 2085             


Ile Phe  Met Gly Leu Ile Gly  Asp Leu Phe Pro Ala  Leu Asp Val 
    2090                 2095                 2100             


Pro Arg  Arg Arg Asp Pro Asn  Phe Glu Ala Leu Val  Arg Lys Ala 
    2105                 2110                 2115             


Ile Val  Asp Leu Lys Leu Gln  Ala Glu Asp Asn Phe  Val Leu Lys 
    2120                 2125                 2130             


Val Val  Gln Leu Glu Glu Leu  Leu Ala Val Arg His  Ser Val Phe 
    2135                 2140                 2145             


Val Val  Gly Gly Ala Gly Thr  Gly Lys Ser Gln Val  Leu Arg Ser 
    2150                 2155                 2160             


Leu His  Lys Thr Tyr Gln Ile  Met Lys Arg Arg Pro  Val Trp Thr 
    2165                 2170                 2175             


Asp Leu  Asn Pro Lys Ala Val  Thr Asn Asp Glu Leu  Phe Gly Ile 
    2180                 2185                 2190             


Ile Asn  Pro Ala Thr Gly Glu  Trp Lys Asp Gly Leu  Phe Ser Ser 
    2195                 2200                 2205             


Ile Met  Arg Glu Leu Ala Asn  Ile Thr His Asp Gly  Pro Lys Trp 
    2210                 2215                 2220             


Ile Leu  Leu Asp Gly Asp Ile  Asp Pro Met Trp Ile  Glu Ser Leu 
    2225                 2230                 2235             


Asn Thr  Val Met Asp Asp Asn  Lys Val Leu Thr Leu  Ala Ser Asn 
    2240                 2245                 2250             


Glu Arg  Ile Pro Leu Asn Pro  Thr Met Lys Leu Leu  Phe Glu Ile 
    2255                 2260                 2265             


Ser His  Leu Arg Thr Ala Thr  Pro Ala Thr Val Ser  Arg Ala Gly 
    2270                 2275                 2280             


Ile Leu  Tyr Ile Asn Pro Ala  Asp Leu Gly Trp Asn  Pro Pro Val 
    2285                 2290                 2295             


Ser Ser  Trp Ile Glu Lys Arg  Glu Ile Gln Thr Glu  Arg Ala Asn 
    2300                 2305                 2310             


Leu Thr  Ile Leu Phe Asp Lys  Tyr Leu Pro Thr Cys  Leu Asp Thr 
    2315                 2320                 2325             


Leu Arg  Thr Arg Phe Lys Lys  Ile Ile Pro Ile Pro  Glu Gln Ser 
    2330                 2335                 2340             


Met Val  Gln Met Val Cys His  Leu Leu Glu Cys Leu  Leu Thr Thr 
    2345                 2350                 2355             


Glu Asp  Ile Pro Ala Asp Cys  Pro Lys Glu Ile Tyr  Glu His Tyr 
    2360                 2365                 2370             


Phe Val  Phe Ala Ala Ile Trp  Ala Phe Gly Gly Ala  Met Val Gln 
    2375                 2380                 2385             


Asp Gln  Leu Val Asp Tyr Arg  Ala Glu Phe Ser Lys  Trp Trp Leu 
    2390                 2395                 2400             


Thr Glu  Phe Lys Thr Val Lys  Phe Pro Ser Gln Gly  Thr Ile Phe 
    2405                 2410                 2415             


Asp Tyr  Tyr Ile Asp Pro Glu  Thr Lys Lys Phe Glu  Pro Trp Ser 
    2420                 2425                 2430             


Lys Leu  Val Pro Gln Phe Glu  Phe Asp Pro Glu Met  Pro Leu Gln 
    2435                 2440                 2445             


Ala Cys  Leu Val His Thr Ser  Glu Thr Ile Arg Val  Cys Tyr Phe 
    2450                 2455                 2460             


Met Glu  Arg Leu Met Ala Arg  Gln Arg Pro Val Met  Leu Val Gly 
    2465                 2470                 2475             


Thr Ala  Gly Thr Gly Lys Ser  Val Leu Val Gly Ala  Lys Leu Ala 
    2480                 2485                 2490             


Ser Leu  Asp Pro Glu Ala Tyr  Leu Val Lys Asn Val  Pro Phe Asn 
    2495                 2500                 2505             


Tyr Tyr  Thr Thr Ser Ala Met  Leu Gln Ala Val Leu  Glu Lys Pro 
    2510                 2515                 2520             


Leu Glu  Lys Lys Ala Gly Arg  Asn Tyr Gly Pro Pro  Gly Asn Lys 
    2525                 2530                 2535             


Lys Leu  Ile Tyr Phe Ile Asp  Asp Met Asn Met Pro  Glu Val Asp 
    2540                 2545                 2550             


Ala Tyr  Gly Thr Val Gln Pro  His Thr Ile Ile Arg  Gln His Leu 
    2555                 2560                 2565             


Asp Tyr  Gly His Trp Tyr Asp  Arg Ser Lys Leu Ser  Leu Lys Glu 
    2570                 2575                 2580             


Ile Thr  Asn Val Gln Tyr Val  Ser Cys Met Asn Pro  Thr Ala Gly 
    2585                 2590                 2595             


Ser Phe  Thr Ile Asn Pro Arg  Leu Gln Arg His Phe  Ser Val Phe 
    2600                 2605                 2610             


Val Leu  Ser Phe Pro Gly Ala  Asp Ala Leu Ser Ser  Ile Tyr Ser 
    2615                 2620                 2625             


Ile Ile  Leu Thr Gln His Leu  Lys Leu Gly Asn Phe  Pro Ala Ser 
    2630                 2635                 2640             


Leu Gln  Lys Ser Ile Pro Pro  Leu Ile Asp Leu Ala  Leu Ala Phe 
    2645                 2650                 2655             


His Gln  Lys Ile Ala Thr Thr  Phe Leu Pro Thr Gly  Ile Lys Phe 
    2660                 2665                 2670             


His Tyr  Ile Phe Asn Leu Arg  Asp Phe Ala Asn Ile  Phe Gln Gly 
    2675                 2680                 2685             


Ile Leu  Phe Ser Ser Val Glu  Cys Val Lys Ser Thr  Trp Asp Leu 
    2690                 2695                 2700             


Ile Arg  Leu Tyr Leu His Glu  Ser Asn Arg Val Tyr  Arg Asp Lys 
    2705                 2710                 2715             


Met Val  Glu Glu Lys Asp Phe  Asp Leu Phe Asp Lys  Ile Gln Thr 
    2720                 2725                 2730             


Glu Val  Leu Lys Lys Thr Phe  Asp Asp Ile Glu Asp  Pro Val Glu 
    2735                 2740                 2745             


Gln Thr  Gln Ser Pro Asn Leu  Tyr Cys His Phe Ala  Asn Gly Ile 
    2750                 2755                 2760             


Gly Glu  Pro Lys Tyr Met Pro  Val Gln Ser Trp Glu  Leu Leu Thr 
    2765                 2770                 2775             


Gln Thr  Leu Val Glu Ala Leu  Glu Asn His Asn Glu  Val Asn Thr 
    2780                 2785                 2790             


Val Met  Asp Leu Val Leu Phe  Glu Asp Ala Met Arg  His Val Cys 
    2795                 2800                 2805             


His Ile  Asn Arg Ile Leu Glu  Ser Pro Arg Gly Asn  Ala Leu Leu 
    2810                 2815                 2820             


Val Gly  Val Gly Gly Ser Gly  Lys Gln Ser Leu Thr  Arg Leu Ala 
    2825                 2830                 2835             


Ala Phe  Ile Ser Ser Met Asp  Val Phe Gln Ile Thr  Leu Arg Lys 
    2840                 2845                 2850             


Gly Tyr  Gln Ile Gln Asp Phe  Lys Met Asp Leu Ala  Ser Leu Cys 
    2855                 2860                 2865             


Leu Lys  Ala Gly Val Lys Asn  Leu Asn Thr Val Phe  Leu Met Thr 
    2870                 2875                 2880             


Asp Ala  Gln Val Ala Asp Glu  Arg Phe Leu Val Leu  Ile Asn Asp 
    2885                 2890                 2895             


Leu Leu  Ala Ser Gly Glu Ile  Pro Asp Leu Tyr Ser  Asp Asp Glu 
    2900                 2905                 2910             


Val Glu  Asn Ile Ile Ser Asn  Val Arg Asn Glu Val  Lys Ser Gln 
    2915                 2920                 2925             


Gly Leu  Val Asp Asn Arg Glu  Asn Cys Trp Lys Phe  Phe Ile Asp 
    2930                 2935                 2940             


Arg Ile  Arg Arg Gln Leu Lys  Val Thr Leu Cys Phe  Ser Pro Val 
    2945                 2950                 2955             


Gly Asn  Lys Leu Arg Val Arg  Ser Arg Lys Phe Pro  Ala Ile Val 
    2960                 2965                 2970             


Asn Cys  Thr Ala Ile His Trp  Phe His Glu Trp Pro  Gln Gln Ala 
    2975                 2980                 2985             


Leu Glu  Ser Val Ser Leu Arg  Phe Leu Gln Asn Thr  Glu Gly Ile 
    2990                 2995                 3000             


Glu Pro  Thr Val Lys Gln Ser  Ile Ser Lys Phe Met  Ala Phe Val 
    3005                 3010                 3015             


His Thr  Ser Val Asn Gln Thr  Ser Gln Ser Tyr Leu  Ser Asn Glu 
    3020                 3025                 3030             


Gln Arg  Tyr Asn Tyr Thr Thr  Pro Lys Ser Phe Leu  Glu Phe Ile 
    3035                 3040                 3045             


Arg Leu  Tyr Gln Ser Leu Leu  His Arg His Arg Lys  Glu Leu Lys 
    3050                 3055                 3060             


Cys Lys  Thr Glu Arg Leu Glu  Asn Gly Leu Leu Lys  Leu His Ser 
    3065                 3070                 3075             


Thr Ser  Ala Gln Val Asp Asp  Leu Lys Ala Lys Leu  Ala Ala Gln 
    3080                 3085                 3090             


Glu Val  Glu Leu Lys Gln Lys  Asn Glu Asp Ala Asp  Lys Leu Ile 
    3095                 3100                 3105             


Gln Val  Val Gly Val Glu Thr  Asp Lys Val Ser Arg  Glu Lys Ala 
    3110                 3115                 3120             


Met Ala  Asp Glu Glu Glu Gln  Lys Val Ala Val Ile  Met Leu Glu 
    3125                 3130                 3135             


Val Lys  Gln Lys Gln Lys Asp  Cys Glu Glu Asp Leu  Ala Lys Ala 
    3140                 3145                 3150             


Glu Pro  Ala Leu Thr Ala Ala  Gln Ala Ala Leu Asn  Thr Leu Asn 
    3155                 3160                 3165             


Lys Thr  Asn Leu Thr Glu Leu  Lys Ser Phe Gly Ser  Pro Pro Leu 
    3170                 3175                 3180             


Ala Val  Ser Asn Val Ser Ala  Ala Val Met Val Leu  Met Ala Pro 
    3185                 3190                 3195             


Arg Gly  Arg Val Pro Lys Asp  Arg Ser Trp Lys Ala  Ala Lys Val 
    3200                 3205                 3210             


Thr Met  Ala Lys Val Asp Gly  Phe Leu Asp Ser Leu  Ile Asn Phe 
    3215                 3220                 3225             


Asn Lys  Glu Asn Ile His Glu  Asn Cys Leu Lys Ala  Ile Arg Pro 
    3230                 3235                 3240             


Tyr Leu  Gln Asp Pro Glu Phe  Asn Pro Glu Phe Val  Ala Thr Lys 
    3245                 3250                 3255             


Ser Tyr  Ala Ala Ala Gly Leu  Cys Ser Trp Val Ile  Asn Ile Val 
    3260                 3265                 3270             


Arg Phe  Tyr Glu Val Phe Cys  Asp Val Glu Pro Lys  Arg Gln Ala 
    3275                 3280                 3285             


Leu Asn  Lys Ala Thr Ala Asp  Leu Thr Ala Ala Gln  Glu Lys Leu 
    3290                 3295                 3300             


Ala Ala  Ile Lys Ala Lys Ile  Ala His Leu Asn Glu  Asn Leu Ala 
    3305                 3310                 3315             


Lys Leu  Thr Ala Arg Phe Glu  Lys Ala Thr Ala Asp  Lys Leu Lys 
    3320                 3325                 3330             


Cys Gln  Gln Glu Ala Glu Val  Thr Ala Val Thr Ile  Ser Leu Ala 
    3335                 3340                 3345             


Asn Arg  Leu Val Gly Gly Leu  Ala Ser Glu Asn Val  Arg Trp Ala 
    3350                 3355                 3360             


Asp Ala  Val Gln Asn Phe Lys  Gln Gln Glu Arg Thr  Leu Cys Gly 
    3365                 3370                 3375             


Asp Ile  Leu Leu Ile Thr Ala  Phe Ile Ser Tyr Leu  Gly Phe Phe 
    3380                 3385                 3390             


Thr Lys  Lys Tyr Arg Gln Ser  Leu Leu Asp Arg Thr  Trp Arg Pro 
    3395                 3400                 3405             


Tyr Leu  Ser Gln Leu Lys Thr  Pro Ile Pro Val Thr  Pro Ala Leu 
    3410                 3415                 3420             


Asp Pro  Leu Arg Met Leu Met  Asp Asp Ala Asp Val  Ala Ala Trp 
    3425                 3430                 3435             


Gln Asn  Glu Gly Leu Pro Ala  Asp Arg Met Ser Val  Glu Asn Ala 
    3440                 3445                 3450             


Thr Ile  Leu Ile Asn Cys Glu  Arg Trp Pro Leu Met  Val Asp Pro 
    3455                 3460                 3465             


Gln Leu  Gln Gly Ile Lys Trp  Ile Lys Asn Lys Tyr  Gly Glu Asp 
    3470                 3475                 3480             


Leu Arg  Val Thr Gln Ile Gly  Gln Lys Gly Tyr Leu  Gln Ile Ile 
    3485                 3490                 3495             


Glu Gln  Ala Leu Glu Ala Gly  Ala Val Val Leu Ile  Glu Asn Leu 
    3500                 3505                 3510             


Glu Glu  Ser Ile Asp Pro Val  Leu Gly Pro Leu Leu  Gly Arg Glu 
    3515                 3520                 3525             


Val Ile  Lys Lys Gly Arg Phe  Ile Lys Ile Gly Asp  Lys Glu Cys 
    3530                 3535                 3540             


Glu Tyr  Asn Pro Lys Phe Arg  Leu Ile Leu His Thr  Lys Leu Ala 
    3545                 3550                 3555             


Asn Pro  His Tyr Gln Pro Glu  Leu Gln Ala Gln Ala  Thr Leu Ile 
    3560                 3565                 3570             


Asn Phe  Thr Val Thr Arg Asp  Gly Leu Glu Asp Gln  Leu Leu Ala 
    3575                 3580                 3585             


Ala Val  Val Ser Met Glu Arg  Pro Asp Leu Glu Gln  Leu Lys Ser 
    3590                 3595                 3600             


Asp Leu  Thr Lys Gln Gln Asn  Gly Phe Lys Ile Thr  Leu Lys Thr 
    3605                 3610                 3615             


Leu Glu  Asp Ser Leu Leu Ser  Arg Leu Ser Ser Ala  Ser Gly Asn 
    3620                 3625                 3630             


Phe Leu  Gly Glu Thr Val Leu  Val Glu Asn Leu Glu  Ile Thr Lys 
    3635                 3640                 3645             


Gln Thr  Ala Ala Glu Val Glu  Lys Lys Val Gln Glu  Ala Lys Val 
    3650                 3655                 3660             


Thr Glu  Val Lys Ile Asn Glu  Ala Arg Glu His Tyr  Arg Pro Ala 
    3665                 3670                 3675             


Ala Ala  Arg Ala Ser Leu Leu  Tyr Phe Ile Met Asn  Asp Leu Ser 
    3680                 3685                 3690             


Lys Ile  His Pro Met Tyr Gln  Phe Ser Leu Lys Ala  Phe Ser Ile 
    3695                 3700                 3705             


Val Phe  Gln Lys Ala Val Glu  Arg Ala Ala Pro Asp  Glu Ser Leu 
    3710                 3715                 3720             


Arg Glu  Arg Val Ala Asn Leu  Ile Asp Ser Ile Thr  Phe Ser Val 
    3725                 3730                 3735             


Tyr Gln  Tyr Thr Ile Arg Gly  Leu Phe Glu Cys Asp  Lys Leu Thr 
    3740                 3745                 3750             


Tyr Leu  Ala Gln Leu Thr Phe  Gln Ile Leu Leu Met  Asn Arg Glu 
    3755                 3760                 3765             


Val Asn  Ala Val Glu Leu Asp  Phe Leu Leu Arg Ser  Pro Val Gln 
    3770                 3775                 3780             


Thr Gly  Thr Ala Ser Pro Val  Glu Phe Leu Ser His  Gln Ala Trp 
    3785                 3790                 3795             


Gly Ala  Val Lys Val Leu Ser  Ser Met Glu Glu Phe  Ser Asn Leu 
    3800                 3805                 3810             


Asp Arg  Asp Ile Glu Gly Ser  Ala Lys Ser Trp Lys  Lys Phe Val 
    3815                 3820                 3825             


Glu Ser  Glu Cys Pro Glu Lys  Glu Lys Leu Pro Gln  Glu Trp Lys 
    3830                 3835                 3840             


Asn Lys  Thr Ala Leu Gln Arg  Leu Cys Met Leu Arg  Ala Met Arg 
    3845                 3850                 3855             


Pro Asp  Arg Met Thr Tyr Ala  Leu Arg Asp Phe Val  Glu Glu Lys 
    3860                 3865                 3870             


Leu Gly  Ser Lys Tyr Val Val  Gly Arg Ala Leu Asp  Phe Ala Thr 
    3875                 3880                 3885             


Ser Phe  Glu Glu Ser Gly Pro  Ala Thr Pro Met Phe  Phe Ile Leu 
    3890                 3895                 3900             


Ser Pro  Gly Val Asp Pro Leu  Lys Asp Val Glu Ser  Gln Gly Arg 
    3905                 3910                 3915             


Lys Leu  Gly Tyr Thr Phe Asn  Asn Gln Asn Phe His  Asn Val Ser 
    3920                 3925                 3930             


Leu Gly  Gln Gly Gln Glu Val  Val Ala Glu Ala Ala  Leu Asp Leu 
    3935                 3940                 3945             


Ala Ala  Lys Lys Gly His Trp  Val Ile Leu Gln Asn  Ile His Leu 
    3950                 3955                 3960             


Val Ala  Lys Trp Leu Ser Thr  Leu Glu Lys Lys Leu  Glu Glu His 
    3965                 3970                 3975             


Ser Glu  Asn Ser His Pro Glu  Phe Arg Val Phe Met  Ser Ala Glu 
    3980                 3985                 3990             


Pro Ala  Pro Ser Pro Glu Gly  His Ile Ile Pro Gln  Gly Ile Leu 
    3995                 4000                 4005             


Glu Asn  Ser Ile Lys Ile Thr  Asn Glu Pro Pro Thr  Gly Met His 
    4010                 4015                 4020             


Ala Asn  Leu His Lys Ala Leu  Asp Asn Phe Thr Gln  Asp Thr Leu 
    4025                 4030                 4035             


Glu Met  Cys Ser Arg Glu Thr  Glu Phe Lys Ser Ile  Leu Phe Ala 
    4040                 4045                 4050             


Leu Cys  Tyr Phe His Ala Val  Val Ala Glu Arg Arg  Lys Phe Gly 
    4055                 4060                 4065             


Pro Gln  Gly Trp Asn Arg Ser  Tyr Pro Phe Asn Thr  Gly Asp Leu 
    4070                 4075                 4080             


Thr Ile  Ser Val Asn Val Leu  Tyr Asn Phe Leu Glu  Ala Asn Ala 
    4085                 4090                 4095             


Lys Val  Pro Tyr Asp Asp Leu  Arg Tyr Leu Phe Gly  Glu Ile Met 
    4100                 4105                 4110             


Tyr Gly  Gly His Ile Thr Asp  Asp Trp Asp Arg Arg  Leu Cys Arg 
    4115                 4120                 4125             


Thr Tyr  Leu Gly Glu Phe Ile  Arg Pro Glu Met Leu  Glu Gly Glu 
    4130                 4135                 4140             


Leu Ser  Leu Ala Pro Gly Phe  Pro Leu Pro Gly Asn  Met Asp Tyr 
    4145                 4150                 4155             


Asn Gly  Tyr His Gln Tyr Ile  Asp Ala Glu Leu Pro  Pro Glu Ser 
    4160                 4165                 4170             


Pro Tyr  Leu Tyr Gly Leu His  Pro Asn Ala Glu Ile  Gly Phe Leu 
    4175                 4180                 4185             


Thr Gln  Thr Ser Glu Lys Leu  Phe Arg Thr Val Leu  Glu Leu Gln 
    4190                 4195                 4200             


Pro Arg  Asp Ser Gln Ala Arg  Asp Gly Ala Gly Ala  Thr Arg Glu 
    4205                 4210                 4215             


Glu Lys  Val Lys Ala Leu Leu  Glu Glu Ile Leu Glu  Arg Val Thr 
    4220                 4225                 4230             


Asp Glu  Phe Asn Ile Pro Glu  Leu Met Ala Lys Val  Glu Glu Arg 
    4235                 4240                 4245             


Thr Pro  Tyr Ile Val Val Ala  Phe Gln Glu Cys Gly  Arg Met Asn 
    4250                 4255                 4260             


Ile Leu  Thr Arg Glu Ile Gln  Arg Ser Leu Arg Glu  Leu Glu Leu 
    4265                 4270                 4275             


Gly Leu  Lys Gly Glu Leu Thr  Met Thr Ser His Met  Glu Asn Leu 
    4280                 4285                 4290             


Gln Asn  Ala Leu Tyr Phe Asp  Met Val Pro Glu Ser  Trp Ala Arg 
    4295                 4300                 4305             


Arg Ala  Tyr Pro Ser Thr Ala  Gly Leu Ala Ala Trp  Phe Pro Asp 
    4310                 4315                 4320             


Leu Leu  Asn Arg Ile Lys Glu  Leu Glu Ala Trp Thr  Gly Asp Phe 
    4325                 4330                 4335             


Thr Met  Pro Ser Thr Val Trp  Leu Thr Gly Phe Phe  Asn Pro Gln 
    4340                 4345                 4350             


Ser Phe  Leu Thr Ala Ile Met  Gln Ser Thr Ala Arg  Lys Asn Glu 
    4355                 4360                 4365             


Trp Pro  Leu Asp Gln Met Ala  Leu Gln Cys Asp Met  Thr Lys Lys 
    4370                 4375                 4380             


Asn Arg  Glu Glu Phe Arg Ser  Pro Pro Arg Glu Gly  Ala Tyr Ile 
    4385                 4390                 4395             


His Gly  Leu Phe Met Glu Gly  Ala Cys Trp Asp Thr  Gln Ala Gly 
    4400                 4405                 4410             


Ile Ile  Thr Glu Ala Lys Leu  Lys Asp Leu Thr Pro  Pro Met Pro 
    4415                 4420                 4425             


Val Met  Phe Ile Lys Ala Ile  Pro Ala Asp Lys Gln  Asp Cys Arg 
    4430                 4435                 4440             


Ser Val  Tyr Ser Cys Pro Val  Tyr Lys Thr Ser Gln  Arg Gly Pro 
    4445                 4450                 4455             


Thr Tyr  Val Trp Thr Phe Asn  Leu Lys Thr Lys Glu  Asn Pro Ser 
    4460                 4465                 4470             


Lys Trp  Val Leu Ala Gly Val  Ala Leu Leu Leu Gln  Ile 
    4475                 4480                 4485     


<210>  3149
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAI1__Homo_sapiens__NP_036276

<400>  3149

Met Ile Pro Ala Ser Ala Lys Ala Pro His Lys Gln Pro His Lys Gln 
1               5                   10                  15      


Ser Ile Ser Ile Gly Arg Gly Thr Arg Lys Arg Asp Glu Asp Ser Gly 
            20                  25                  30          


Thr Glu Val Gly Glu Gly Thr Asp Glu Trp Ala Gln Ser Lys Ala Thr 
        35                  40                  45              


Val Arg Pro Pro Asp Gln Leu Glu Leu Thr Asp Ala Glu Leu Lys Glu 
    50                  55                  60                  


Glu Phe Thr Arg Ile Leu Thr Ala Asn Asn Pro His Ala Pro Gln Asn 
65                  70                  75                  80  


Ile Val Arg Tyr Ser Phe Lys Glu Gly Thr Tyr Lys Pro Ile Gly Phe 
                85                  90                  95      


Val Asn Gln Leu Ala Val His Tyr Thr Gln Val Gly Asn Leu Ile Pro 
            100                 105                 110         


Lys Asp Ser Asp Glu Gly Arg Arg Gln His Tyr Arg Asp Glu Leu Val 
        115                 120                 125             


Ala Gly Ser Gln Glu Ser Val Lys Val Ile Ser Glu Thr Gly Asn Leu 
    130                 135                 140                 


Glu Glu Asp Glu Glu Pro Lys Glu Leu Glu Thr Glu Pro Gly Ser Gln 
145                 150                 155                 160 


Thr Asp Val Pro Ala Ala Gly Ala Ala Glu Lys Val Thr Glu Glu Glu 
                165                 170                 175     


Leu Met Thr Pro Lys Gln Pro Lys Glu Arg Lys Leu Thr Asn Gln Phe 
            180                 185                 190         


Asn Phe Ser Glu Arg Ala Ser Gln Thr Tyr Asn Asn Pro Val Arg Asp 
        195                 200                 205             


Arg Glu Cys Gln Thr Glu Pro Pro Pro Arg Thr Asn Phe Ser Ala Thr 
    210                 215                 220                 


Ala Asn Gln Trp Glu Ile Tyr Asp Ala Tyr Val Glu Glu Leu Glu Lys 
225                 230                 235                 240 


Gln Glu Lys Thr Lys Glu Lys Glu Lys Ala Lys Thr Pro Val Ala Lys 
                245                 250                 255     


Lys Ser Gly Lys Met Ala Met Arg Lys Leu Thr Ser Met Glu Ser Gln 
            260                 265                 270         


Thr Asp Asp Leu Ile Lys Leu Ser Gln Ala Ala Lys Ile Met Glu Arg 
        275                 280                 285             


Met Val Asn Gln Asn Thr Tyr Asp Asp Ile Ala Gln Asp Phe Lys Tyr 
    290                 295                 300                 


Tyr Asp Asp Ala Ala Asp Glu Tyr Arg Asp Gln Val Gly Thr Leu Leu 
305                 310                 315                 320 


Pro Leu Trp Lys Phe Gln Asn Asp Lys Ala Lys Arg Leu Ser Val Thr 
                325                 330                 335     


Ala Leu Cys Trp Asn Pro Lys Tyr Arg Asp Leu Phe Ala Val Gly Tyr 
            340                 345                 350         


Gly Ser Tyr Asp Phe Met Lys Gln Ser Arg Gly Met Leu Leu Leu Tyr 
        355                 360                 365             


Ser Leu Lys Asn Pro Ser Phe Pro Glu Tyr Met Phe Ser Ser Asn Ser 
    370                 375                 380                 


Gly Val Met Cys Leu Asp Ile His Val Asp His Pro Tyr Leu Val Ala 
385                 390                 395                 400 


Val Gly His Tyr Asp Gly Asn Val Ala Ile Tyr Asn Leu Lys Lys Pro 
                405                 410                 415     


His Ser Gln Pro Ser Phe Cys Ser Ser Ala Lys Ser Gly Lys His Ser 
            420                 425                 430         


Asp Pro Val Trp Gln Val Lys Trp Gln Lys Asp Asp Met Asp Gln Asn 
        435                 440                 445             


Leu Asn Phe Phe Ser Val Ser Ser Asp Gly Arg Ile Val Ser Trp Thr 
    450                 455                 460                 


Leu Val Lys Arg Lys Leu Val His Ile Asp Val Ile Lys Leu Lys Val 
465                 470                 475                 480 


Glu Gly Ser Thr Thr Glu Val Pro Glu Gly Leu Gln Leu His Pro Val 
                485                 490                 495     


Gly Cys Gly Thr Ala Phe Asp Phe His Lys Glu Ile Asp Tyr Met Phe 
            500                 505                 510         


Leu Val Gly Thr Glu Glu Gly Lys Ile Tyr Lys Cys Ser Lys Ser Tyr 
        515                 520                 525             


Ser Ser Gln Phe Leu Asp Thr Tyr Asp Ala His Asn Met Ser Val Asp 
    530                 535                 540                 


Thr Val Ser Trp Asn Pro Tyr His Thr Lys Val Phe Met Ser Cys Ser 
545                 550                 555                 560 


Ser Asp Trp Thr Val Lys Ile Trp Asp His Thr Ile Lys Thr Pro Met 
                565                 570                 575     


Phe Ile Tyr Asp Leu Asn Ser Ala Val Gly Asp Val Ala Trp Ala Pro 
            580                 585                 590         


Tyr Ser Ser Thr Val Phe Ala Ala Val Thr Thr Asp Gly Lys Ala His 
        595                 600                 605             


Ile Phe Asp Leu Ala Ile Asn Lys Tyr Glu Ala Ile Cys Asn Gln Pro 
    610                 615                 620                 


Val Ala Ala Lys Lys Asn Arg Leu Thr His Val Gln Phe Asn Leu Ile 
625                 630                 635                 640 


His Pro Ile Ile Ile Val Gly Asp Asp Arg Gly His Ile Ile Ser Leu 
                645                 650                 655     


Lys Leu Ser Pro Asn Leu Arg Lys Met Pro Lys Glu Lys Lys Gly Gln 
            660                 665                 670         


Glu Val Gln Lys Gly Pro Ala Val Glu Ile Ala Lys Leu Asp Lys Leu 
        675                 680                 685             


Leu Asn Leu Val Arg Glu Val Lys Ile Lys Thr 
    690                 695                 


<210>  3150
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAI2__Homo_sapiens__NP_001166281

<400>  3150

Met Glu Ile Val Tyr Val Tyr Val Lys Lys Arg Ser Glu Phe Gly Lys 
1               5                   10                  15      


Gln Cys Asn Phe Ser Asp Arg Gln Ala Glu Leu Asn Ile Asp Ile Met 
            20                  25                  30          


Pro Asn Pro Glu Leu Ala Glu Gln Phe Val Glu Arg Asn Pro Val Asp 
        35                  40                  45              


Thr Gly Ile Gln Cys Ser Ile Ser Met Ser Glu His Glu Ala Asn Ser 
    50                  55                  60                  


Glu Arg Phe Glu Met Glu Thr Arg Gly Val Asn His Val Glu Gly Gly 
65                  70                  75                  80  


Trp Pro Lys Asp Val Asn Pro Leu Glu Leu Glu Gln Thr Ile Arg Phe 
                85                  90                  95      


Arg Lys Lys Val Glu Lys Asp Glu Asn Tyr Val Asn Ala Ile Met Gln 
            100                 105                 110         


Leu Gly Ser Ile Met Glu His Cys Ile Lys Gln Asn Asn Ala Ile Asp 
        115                 120                 125             


Ile Tyr Glu Glu Tyr Phe Asn Asp Glu Glu Ala Met Glu Val Met Glu 
    130                 135                 140                 


Glu Asp Pro Ser Ala Lys Thr Ile Asn Val Phe Arg Asp Pro Gln Glu 
145                 150                 155                 160 


Ile Lys Arg Ala Ala Thr His Leu Ser Trp His Pro Asp Gly Asn Arg 
                165                 170                 175     


Lys Leu Ala Val Ala Tyr Ser Cys Leu Asp Phe Gln Arg Ala Pro Val 
            180                 185                 190         


Gly Met Ser Ser Asp Ser Tyr Ile Trp Asp Leu Glu Asn Pro Asn Lys 
        195                 200                 205             


Pro Glu Leu Ala Leu Lys Pro Ser Ser Pro Leu Val Thr Leu Glu Phe 
    210                 215                 220                 


Asn Pro Lys Asp Ser His Val Leu Leu Gly Gly Cys Tyr Asn Gly Gln 
225                 230                 235                 240 


Ile Ala Cys Trp Asp Thr Arg Lys Gly Ser Leu Val Ala Glu Leu Ser 
                245                 250                 255     


Thr Ile Glu Ser Ser His Arg Asp Pro Val Tyr Gly Thr Ile Trp Leu 
            260                 265                 270         


Gln Ser Lys Thr Gly Thr Glu Cys Phe Ser Ala Ser Thr Asp Gly Gln 
        275                 280                 285             


Val Met Trp Trp Asp Ile Arg Lys Met Ser Glu Pro Thr Glu Val Val 
    290                 295                 300                 


Ile Leu Asp Ile Thr Lys Lys Glu Gln Leu Glu Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Ile Ser Leu Glu Phe Glu Ser Thr Leu Pro Thr Lys Phe Met Val Gly 
                325                 330                 335     


Thr Glu Gln Gly Ile Val Ile Ser Cys Asn Arg Lys Ala Lys Thr Ser 
            340                 345                 350         


Ala Glu Lys Ile Val Cys Thr Phe Pro Gly His His Gly Pro Ile Tyr 
        355                 360                 365             


Ala Leu Gln Arg Asn Pro Phe Tyr Pro Lys Asn Phe Leu Thr Val Gly 
    370                 375                 380                 


Asp Trp Thr Ala Arg Ile Trp Ser Glu Asp Ser Arg Glu Ser Ser Ile 
385                 390                 395                 400 


Met Trp Thr Lys Tyr His Met Ala Tyr Leu Thr Asp Ala Ala Trp Ser 
                405                 410                 415     


Pro Val Arg Pro Thr Val Phe Phe Thr Thr Arg Met Asp Gly Thr Leu 
            420                 425                 430         


Asp Ile Trp Asp Phe Met Phe Glu Gln Cys Asp Pro Thr Leu Ser Leu 
        435                 440                 445             


Lys Asp Asn Gly Cys Leu Ile Ala Cys Gly Ser Gln Leu Gly Thr Thr 
    450                 455                 460                 


Thr Leu Leu Glu Val Ser Pro Gly Leu Ser Thr Leu Gln Arg Asn Glu 
465                 470                 475                 480 


Lys Asn Val Ala Ser Ser Met Phe Glu Arg Glu Thr Arg Arg Glu Lys 
                485                 490                 495     


Ile Leu Glu Ala Arg His Arg Glu Met Arg Leu Lys Glu Lys Gly Lys 
            500                 505                 510         


Ala Glu Gly Arg Asp Glu Glu Gln Thr Asp Glu Glu Leu Ala Val Asp 
        515                 520                 525             


Leu Glu Ala Leu Val Ser Lys Ala Glu Glu Glu Phe Phe Asp Ile Ile 
    530                 535                 540                 


Phe Ala Glu Leu Lys Lys Lys Glu Ala Asp Ala Ile Lys Leu Thr Pro 
545                 550                 555                 560 


Val Pro Gln Gln Pro Ser Pro Glu Glu Asp Gln Val Val Glu Glu Gly 
                565                 570                 575     


Glu Glu Ala Ala Gly Glu Glu Gly Asp Glu Glu Val Glu Glu Asp Leu 
            580                 585                 590         


Ala 
    


<210>  3151
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJA1__Homo_sapiens__NP_001530

<400>  3151

Met Val Lys Glu Thr Thr Tyr Tyr Asp Val Leu Gly Val Lys Pro Asn 
1               5                   10                  15      


Ala Thr Gln Glu Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys 
            20                  25                  30          


Tyr His Pro Asp Lys Asn Pro Asn Glu Gly Glu Lys Phe Lys Gln Ile 
        35                  40                  45              


Ser Gln Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Glu Leu Tyr 
    50                  55                  60                  


Asp Lys Gly Gly Glu Gln Ala Ile Lys Glu Gly Gly Ala Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Ser Pro Met Asp Ile Phe Asp Met Phe Phe Gly Gly Gly Gly 
                85                  90                  95      


Arg Met Gln Arg Glu Arg Arg Gly Lys Asn Val Val His Gln Leu Ser 
            100                 105                 110         


Val Thr Leu Glu Asp Leu Tyr Asn Gly Ala Thr Arg Lys Leu Ala Leu 
        115                 120                 125             


Gln Lys Asn Val Ile Cys Asp Lys Cys Glu Gly Arg Gly Gly Lys Lys 
    130                 135                 140                 


Gly Ala Val Glu Cys Cys Pro Asn Cys Arg Gly Thr Gly Met Gln Ile 
145                 150                 155                 160 


Arg Ile His Gln Ile Gly Pro Gly Met Val Gln Gln Ile Gln Ser Val 
                165                 170                 175     


Cys Met Glu Cys Gln Gly His Gly Glu Arg Ile Ser Pro Lys Asp Arg 
            180                 185                 190         


Cys Lys Ser Cys Asn Gly Arg Lys Ile Val Arg Glu Lys Lys Ile Leu 
        195                 200                 205             


Glu Val His Ile Asp Lys Gly Met Lys Asp Gly Gln Lys Ile Thr Phe 
    210                 215                 220                 


His Gly Glu Gly Asp Gln Glu Pro Gly Leu Glu Pro Gly Asp Ile Ile 
225                 230                 235                 240 


Ile Val Leu Asp Gln Lys Asp His Ala Val Phe Thr Arg Arg Gly Glu 
                245                 250                 255     


Asp Leu Phe Met Cys Met Asp Ile Gln Leu Val Glu Ala Leu Cys Gly 
            260                 265                 270         


Phe Gln Lys Pro Ile Ser Thr Leu Asp Asn Arg Thr Ile Val Ile Thr 
        275                 280                 285             


Ser His Pro Gly Gln Ile Val Lys His Gly Asp Ile Lys Cys Val Leu 
    290                 295                 300                 


Asn Glu Gly Met Pro Ile Tyr Arg Arg Pro Tyr Glu Lys Gly Arg Leu 
305                 310                 315                 320 


Ile Ile Glu Phe Lys Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro 
                325                 330                 335     


Asp Lys Leu Ser Leu Leu Glu Lys Leu Leu Pro Glu Arg Lys Glu Val 
            340                 345                 350         


Glu Glu Thr Asp Glu Met Asp Gln Val Glu Leu Val Asp Phe Asp Pro 
        355                 360                 365             


Asn Gln Glu Arg Arg Arg His Tyr Asn Gly Glu Ala Tyr Glu Asp Asp 
    370                 375                 380                 


Glu His His Pro Arg Gly Gly Val Gln Cys Gln Thr Ser 
385                 390                 395         


<210>  3152
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJA2__Homo_sapiens__NP_005871

<400>  3152

Met Ala Asn Val Ala Asp Thr Lys Leu Tyr Asp Ile Leu Gly Val Pro 
1               5                   10                  15      


Pro Gly Ala Ser Glu Asn Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala 
            20                  25                  30          


Lys Glu Tyr His Pro Asp Lys Asn Pro Asn Ala Gly Asp Lys Phe Lys 
        35                  40                  45              


Glu Ile Ser Phe Ala Tyr Glu Val Leu Ser Asn Pro Glu Lys Arg Glu 
    50                  55                  60                  


Leu Tyr Asp Arg Tyr Gly Glu Gln Gly Leu Arg Glu Gly Ser Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Met Asp Asp Ile Phe Ser His Ile Phe Gly Gly Gly Leu 
                85                  90                  95      


Phe Gly Phe Met Gly Asn Gln Ser Arg Ser Arg Asn Gly Arg Arg Arg 
            100                 105                 110         


Gly Glu Asp Met Met His Pro Leu Lys Val Ser Leu Glu Asp Leu Tyr 
        115                 120                 125             


Asn Gly Lys Thr Thr Lys Leu Gln Leu Ser Lys Asn Val Leu Cys Ser 
    130                 135                 140                 


Ala Cys Ser Gly Gln Gly Gly Lys Ser Gly Ala Val Gln Lys Cys Ser 
145                 150                 155                 160 


Ala Cys Arg Gly Arg Gly Val Arg Ile Met Ile Arg Gln Leu Ala Pro 
                165                 170                 175     


Gly Met Val Gln Gln Met Gln Ser Val Cys Ser Asp Cys Asn Gly Glu 
            180                 185                 190         


Gly Glu Val Ile Asn Glu Lys Asp Arg Cys Lys Lys Cys Glu Gly Lys 
        195                 200                 205             


Lys Val Ile Lys Glu Val Lys Ile Leu Glu Val His Val Asp Lys Gly 
    210                 215                 220                 


Met Lys His Gly Gln Arg Ile Thr Phe Thr Gly Glu Ala Asp Gln Ala 
225                 230                 235                 240 


Pro Gly Val Glu Pro Gly Asp Ile Val Leu Leu Leu Gln Glu Lys Glu 
                245                 250                 255     


His Glu Val Phe Gln Arg Asp Gly Asn Asp Leu His Met Thr Tyr Lys 
            260                 265                 270         


Ile Gly Leu Val Glu Ala Leu Cys Gly Phe Gln Phe Thr Phe Lys His 
        275                 280                 285             


Leu Asp Gly Arg Gln Ile Val Val Lys Tyr Pro Pro Gly Lys Val Ile 
    290                 295                 300                 


Glu Pro Gly Cys Val Arg Val Val Arg Gly Glu Gly Met Pro Gln Tyr 
305                 310                 315                 320 


Arg Asn Pro Phe Glu Lys Gly Asp Leu Tyr Ile Lys Phe Asp Val Gln 
                325                 330                 335     


Phe Pro Glu Asn Asn Trp Ile Asn Pro Asp Lys Leu Ser Glu Leu Glu 
            340                 345                 350         


Asp Leu Leu Pro Ser Arg Pro Glu Val Pro Asn Ile Ile Gly Glu Thr 
        355                 360                 365             


Glu Glu Val Glu Leu Gln Glu Phe Asp Ser Thr Arg Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gln Arg Arg Glu Ala Tyr Asn Asp Ser Ser Asp Glu Glu Ser Ser 
385                 390                 395                 400 


Ser His His Gly Pro Gly Val Gln Cys Ala His Gln 
                405                 410         


<210>  3153
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJA3__Homo_sapiens__NP_001128582

<400>  3153

Met Ala Ala Arg Cys Ser Thr Arg Trp Leu Leu Val Val Val Gly Thr 
1               5                   10                  15      


Pro Arg Leu Pro Ala Ile Ser Gly Arg Gly Ala Arg Pro Pro Arg Glu 
            20                  25                  30          


Gly Val Val Gly Ala Trp Leu Ser Arg Lys Leu Ser Val Pro Ala Phe 
        35                  40                  45              


Ala Ser Ser Leu Thr Ser Cys Gly Pro Arg Ala Leu Leu Thr Leu Arg 
    50                  55                  60                  


Pro Gly Val Ser Leu Thr Gly Thr Lys His Asn Pro Phe Ile Cys Thr 
65                  70                  75                  80  


Ala Ser Phe His Thr Ser Ala Pro Leu Ala Lys Glu Asp Tyr Tyr Gln 
                85                  90                  95      


Ile Leu Gly Val Pro Arg Asn Ala Ser Gln Lys Glu Ile Lys Lys Ala 
            100                 105                 110         


Tyr Tyr Gln Leu Ala Lys Lys Tyr His Pro Asp Thr Asn Lys Asp Asp 
        115                 120                 125             


Pro Lys Ala Lys Glu Lys Phe Ser Gln Leu Ala Glu Ala Tyr Glu Val 
    130                 135                 140                 


Leu Ser Asp Glu Val Lys Arg Lys Gln Tyr Asp Ala Tyr Gly Ser Ala 
145                 150                 155                 160 


Gly Phe Asp Pro Gly Ala Ser Gly Ser Gln His Ser Tyr Trp Lys Gly 
                165                 170                 175     


Gly Pro Thr Val Asp Pro Glu Glu Leu Phe Arg Lys Ile Phe Gly Glu 
            180                 185                 190         


Phe Ser Ser Ser Ser Phe Gly Asp Phe Gln Thr Val Phe Asp Gln Pro 
        195                 200                 205             


Gln Glu Tyr Phe Met Glu Leu Thr Phe Asn Gln Ala Ala Lys Gly Val 
    210                 215                 220                 


Asn Lys Glu Phe Thr Val Asn Ile Met Asp Thr Cys Glu Arg Cys Asn 
225                 230                 235                 240 


Gly Lys Gly Asn Glu Pro Gly Thr Lys Val Gln His Cys His Tyr Cys 
                245                 250                 255     


Gly Gly Ser Gly Met Glu Thr Ile Asn Thr Gly Pro Phe Val Met Arg 
            260                 265                 270         


Ser Thr Cys Arg Arg Cys Gly Gly Arg Gly Ser Ile Ile Ile Ser Pro 
        275                 280                 285             


Cys Val Val Cys Arg Gly Ala Gly Gln Ala Lys Gln Lys Lys Arg Val 
    290                 295                 300                 


Met Ile Pro Val Pro Ala Gly Val Glu Asp Gly Gln Thr Val Arg Met 
305                 310                 315                 320 


Pro Val Gly Lys Arg Glu Ile Phe Ile Thr Phe Arg Val Gln Lys Ser 
                325                 330                 335     


Pro Val Phe Arg Arg Asp Gly Ala Asp Ile His Ser Asp Leu Phe Ile 
            340                 345                 350         


Ser Ile Ala Gln Ala Leu Leu Gly Gly Thr Ala Arg Ala Gln Gly Leu 
        355                 360                 365             


Tyr Glu Thr Ile Asn Val Thr Ile Pro Pro Gly Thr Gln Thr Asp Gln 
    370                 375                 380                 


Lys Ile Arg Met Gly Gly Lys Gly Ile Pro Arg Ile Asn Ser Tyr Gly 
385                 390                 395                 400 


Tyr Gly Asp His Tyr Ile His Ile Lys Ile Arg Val Pro Lys Arg Leu 
                405                 410                 415     


Thr Ser Arg Gln Gln Ser Leu Ile Leu Ser Tyr Ala Glu Asp Glu Thr 
            420                 425                 430         


Asp Val Glu Gly Thr Val Asn Gly Val Thr Leu Thr Ser Ser Gly Lys 
        435                 440                 445             


Arg Ser Thr Gly Asn 
    450             


<210>  3154
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB11__Homo_sapiens__NP_057390

<400>  3154

Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 
            20                  25                  30          


Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 
        35                  40                  45              


Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 
    50                  55                  60                  


Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 
65                  70                  75                  80  


Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 
                85                  90                  95      


Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 
            100                 105                 110         


Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 
        115                 120                 125             


Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 
    130                 135                 140                 


Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 
                165                 170                 175     


Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 
            180                 185                 190         


Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 
        195                 200                 205             


Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 
    210                 215                 220                 


Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 
225                 230                 235                 240 


Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 
                245                 250                 255     


Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 
            260                 265                 270         


Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 
        275                 280                 285             


Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 
    290                 295                 300                 


Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 
305                 310                 315                 320 


Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 
                325                 330                 335     


Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 
            340                 345                 350         


Asn Gly Leu Gln Gly Tyr 
        355             


<210>  3155
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB13__Homo_sapiens__NP_705842

<400>  3155

Met Gly Gln Asp Tyr Tyr Ser Val Leu Gly Ile Thr Arg Asn Ser Glu 
1               5                   10                  15      


Asp Ala Gln Ile Lys Gln Ala Tyr Arg Arg Leu Ala Leu Lys His His 
            20                  25                  30          


Pro Leu Lys Ser Asn Glu Pro Ser Ser Ala Glu Ile Phe Arg Gln Ile 
        35                  40                  45              


Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Met Lys Arg Gly Ile Tyr 
    50                  55                  60                  


Asp Lys Phe Gly Glu Glu Gly Leu Lys Gly Gly Ile Pro Leu Glu Phe 
65                  70                  75                  80  


Gly Ser Gln Thr Pro Trp Thr Thr Gly Tyr Val Phe His Gly Lys Pro 
                85                  90                  95      


Glu Lys Val Phe His Glu Phe Phe Gly Gly Asn Asn Pro Phe Ser Glu 
            100                 105                 110         


Phe Phe Asp Ala Glu Gly Ser Glu Val Asp Leu Asn Phe Gly Gly Leu 
        115                 120                 125             


Gln Gly Arg Gly Val Lys Lys Gln Asp Pro Gln Val Glu Arg Asp Leu 
    130                 135                 140                 


Tyr Leu Ser Leu Glu Asp Leu Phe Phe Gly Cys Thr Lys Lys Ile Lys 
145                 150                 155                 160 


Ile Ser Arg Arg Val Leu Asn Glu Asp Gly Tyr Ser Ser Thr Ile Lys 
                165                 170                 175     


Asp Lys Ile Leu Thr Ile Asp Val Lys Pro Gly Trp Arg Gln Gly Thr 
            180                 185                 190         


Arg Ile Thr Phe Glu Lys Glu Gly Asp Gln Gly Pro Asn Ile Ile Pro 
        195                 200                 205             


Ala Asp Ile Ile Phe Ile Val Lys Glu Lys Leu His Pro Arg Phe Arg 
    210                 215                 220                 


Arg Glu Asn Asp Asn Leu Phe Phe Val Asn Pro Ile Pro Leu Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Cys Cys Thr Val Glu Val Arg Thr Leu Asp Asp Arg Leu 
                245                 250                 255     


Leu Asn Ile Pro Ile Asn Asp Ile Ile His Pro Lys Tyr Phe Lys Lys 
            260                 265                 270         


Val Pro Gly Glu Gly Met Pro Leu Pro Glu Asp Pro Thr Lys Lys Gly 
        275                 280                 285             


Asp Leu Phe Ile Phe Phe Asp Ile Gln Phe Pro Thr Arg Leu Thr Pro 
    290                 295                 300                 


Gln Lys Lys Gln Met Leu Arg Gln Ala Leu Leu Thr 
305                 310                 315     


<210>  3156
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB1__Homo_sapiens__NP_001287843

<400>  3156

Met Phe Ala Glu Phe Phe Gly Gly Arg Asn Pro Phe Asp Thr Phe Phe 
1               5                   10                  15      


Gly Gln Arg Asn Gly Glu Glu Gly Met Asp Ile Asp Asp Pro Phe Ser 
            20                  25                  30          


Gly Phe Pro Met Gly Met Gly Gly Phe Thr Asn Val Asn Phe Gly Arg 
        35                  40                  45              


Ser Arg Ser Ala Gln Glu Pro Ala Arg Lys Lys Gln Asp Pro Pro Val 
    50                  55                  60                  


Thr His Asp Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
65                  70                  75                  80  


Lys Lys Met Lys Ile Ser His Lys Arg Leu Asn Pro Asp Gly Lys Ser 
                85                  90                  95      


Ile Arg Asn Glu Asp Lys Ile Leu Thr Ile Glu Val Lys Lys Gly Trp 
            100                 105                 110         


Lys Glu Gly Thr Lys Ile Thr Phe Pro Lys Glu Gly Asp Gln Thr Ser 
        115                 120                 125             


Asn Asn Ile Pro Ala Asp Ile Val Phe Val Leu Lys Asp Lys Pro His 
    130                 135                 140                 


Asn Ile Phe Lys Arg Asp Gly Ser Asp Val Ile Tyr Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Leu Arg Glu Ala Leu Cys Gly Cys Thr Val Asn Val Pro Thr Leu 
                165                 170                 175     


Asp Gly Arg Thr Ile Pro Val Val Phe Lys Asp Val Ile Arg Pro Gly 
            180                 185                 190         


Met Arg Arg Lys Val Pro Gly Glu Gly Leu Pro Leu Pro Lys Thr Pro 
        195                 200                 205             


Glu Lys Arg Gly Asp Leu Ile Ile Glu Phe Glu Val Ile Phe Pro Glu 
    210                 215                 220                 


Arg Ile Pro Gln Thr Ser Arg Thr Val Leu Glu Gln Val Leu Pro Ile 
225                 230                 235                 240 


<210>  3157
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB2__Homo_sapiens__NP_001034639

<400>  3157

Met Ala Ser Tyr Tyr Glu Ile Leu Asp Val Pro Arg Ser Ala Ser Ala 
1               5                   10                  15      


Asp Asp Ile Lys Lys Ala Tyr Arg Arg Lys Ala Leu Gln Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Asp Asn Lys Glu Phe Ala Glu Lys Lys Phe Lys Glu 
        35                  40                  45              


Val Ala Glu Ala Tyr Glu Val Leu Ser Asp Lys His Lys Arg Glu Ile 
    50                  55                  60                  


Tyr Asp Arg Tyr Gly Arg Glu Gly Leu Thr Gly Thr Gly Thr Gly Pro 
65                  70                  75                  80  


Ser Arg Ala Glu Ala Gly Ser Gly Gly Pro Gly Phe Thr Phe Thr Phe 
                85                  90                  95      


Arg Ser Pro Glu Glu Val Phe Arg Glu Phe Phe Gly Ser Gly Asp Pro 
            100                 105                 110         


Phe Ala Glu Leu Phe Asp Asp Leu Gly Pro Phe Ser Glu Leu Gln Asn 
        115                 120                 125             


Arg Gly Ser Arg His Ser Gly Pro Phe Phe Thr Phe Ser Ser Ser Phe 
    130                 135                 140                 


Pro Gly His Ser Asp Phe Ser Ser Ser Ser Phe Ser Phe Ser Pro Gly 
145                 150                 155                 160 


Ala Gly Ala Phe Arg Ser Val Ser Thr Ser Thr Thr Phe Val Gln Gly 
                165                 170                 175     


Arg Arg Ile Thr Thr Arg Arg Ile Met Glu Asn Gly Gln Glu Arg Val 
            180                 185                 190         


Glu Val Glu Glu Asp Gly Gln Leu Lys Ser Val Thr Ile Asn Gly Val 
        195                 200                 205             


Pro Asp Asp Leu Ala Leu Gly Leu Glu Leu Ser Arg Arg Glu Gln Gln 
    210                 215                 220                 


Pro Ser Val Thr Ser Arg Ser Gly Gly Thr Gln Val Gln Gln Thr Pro 
225                 230                 235                 240 


Ala Ser Cys Pro Leu Asp Ser Asp Leu Ser Glu Asp Glu Asp Leu Gln 
                245                 250                 255     


Leu Ala Met Ala Tyr Ser Leu Ser Glu Met Glu Ala Ala Gly Lys Lys 
            260                 265                 270         


Pro Ala Asp Val Phe 
        275         


<210>  3158
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB5__Homo_sapiens__NP_001128476

<400>  3158

Met Gly Gly Ala Glu Ala Glu Pro Trp Gly Arg Ala Pro Gly Pro Ala 
1               5                   10                  15      


Ile Gly Gly Arg Arg Ala Gly Asp Ser Cys Pro Gly Trp Arg Arg Arg 
            20                  25                  30          


Ser Arg Ser Arg Gly Arg Gly Gln Arg Leu Ser His Gly Pro Arg Arg 
        35                  40                  45              


Arg Pro Gln Leu Leu Thr Ala Ala Pro Pro Leu Gln Ala Arg Gly Ala 
    50                  55                  60                  


Phe Arg Ser Phe Pro His Ser Trp Gly Glu Asp Phe Leu Ala Ser Leu 
65                  70                  75                  80  


Met Phe Lys Ile Gln Leu Glu Pro Leu Lys Leu Arg Ala Trp Thr Leu 
                85                  90                  95      


Asn Gly Phe Val Lys Phe Arg Asn Lys Glu Thr Ser Ala Gly Pro Val 
            100                 105                 110         


Ala Val Met Gly Lys Asp Tyr Tyr Lys Ile Leu Gly Ile Pro Ser Gly 
        115                 120                 125             


Ala Asn Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Met Ala Leu Lys 
    130                 135                 140                 


Tyr His Pro Asp Lys Asn Lys Glu Pro Asn Ala Glu Glu Lys Phe Lys 
145                 150                 155                 160 


Glu Ile Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Lys Lys Arg Gly 
                165                 170                 175     


Leu Tyr Asp Gln Tyr Gly Glu Glu Gly Leu Lys Thr Gly Gly Gly Thr 
            180                 185                 190         


Ser Gly Gly Ser Ser Gly Ser Phe His Tyr Thr Phe His Gly Asp Pro 
        195                 200                 205             


His Ala Thr Phe Ala Ser Phe Phe Gly Gly Ser Asn Pro Phe Asp Ile 
    210                 215                 220                 


Phe Phe Ala Ser Ser Arg Ser Thr Arg Pro Phe Ser Gly Phe Asp Pro 
225                 230                 235                 240 


Asp Asp Met Asp Val Asp Glu Asp Glu Asp Pro Phe Gly Ala Phe Gly 
                245                 250                 255     


Arg Phe Gly Phe Asn Gly Leu Ser Arg Gly Pro Arg Arg Ala Pro Glu 
            260                 265                 270         


Pro Leu Tyr Pro Arg Arg Lys Val Gln Asp Pro Pro Val Val His Glu 
        275                 280                 285             


Leu Arg Val Ser Leu Glu Glu Ile Tyr His Gly Ser Thr Lys Arg Met 
    290                 295                 300                 


Lys Ile Thr Arg Arg Arg Leu Asn Pro Asp Gly Arg Thr Val Arg Thr 
305                 310                 315                 320 


Glu Asp Lys Ile Leu His Ile Val Ile Lys Arg Gly Trp Lys Glu Gly 
                325                 330                 335     


Thr Lys Ile Thr Phe Pro Lys Glu Gly Asp Ala Thr Pro Asp Asn Ile 
            340                 345                 350         


Pro Ala Asp Ile Val Phe Val Leu Lys Asp Lys Pro His Ala His Phe 
        355                 360                 365             


Arg Arg Asp Gly Thr Asn Val Leu Tyr Ser Ala Leu Ile Ser Leu Lys 
    370                 375                 380                 


Glu Ala Leu Cys Gly Cys Thr Val Asn Ile Pro Thr Ile Asp Gly Arg 
385                 390                 395                 400 


Val Ile Pro Leu Pro Cys Asn Asp Val Ile Lys Pro Gly Thr Val Lys 
                405                 410                 415     


Arg Leu Arg Gly Glu Gly Leu Pro Phe Pro Lys Val Pro Thr Gln Arg 
            420                 425                 430         


Gly Asp Leu Ile Val Glu Phe Lys Val Arg Phe Pro Asp Arg Leu Thr 
        435                 440                 445             


Pro Gln Thr Arg Gln Ile Leu Lys Gln His Leu Pro Cys Ser 
    450                 455                 460         


<210>  3159
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB6__Homo_sapiens__NP_005485

<400>  3159

Met Val Asp Tyr Tyr Glu Val Leu Gly Val Gln Arg His Ala Ser Pro 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Glu Asn Lys Glu Glu Ala Glu Arg Lys Phe Lys Gln 
        35                  40                  45              


Val Ala Glu Ala Tyr Glu Val Leu Ser Asp Ala Lys Lys Arg Asp Ile 
    50                  55                  60                  


Tyr Asp Lys Tyr Gly Lys Glu Gly Leu Asn Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ser His Phe Asp Ser Pro Phe Glu Phe Gly Phe Thr Phe Arg Asn Pro 
                85                  90                  95      


Asp Asp Val Phe Arg Glu Phe Phe Gly Gly Arg Asp Pro Phe Ser Phe 
            100                 105                 110         


Asp Phe Phe Glu Asp Pro Phe Glu Asp Phe Phe Gly Asn Arg Arg Gly 
        115                 120                 125             


Pro Arg Gly Ser Arg Ser Arg Gly Thr Gly Ser Phe Phe Ser Ala Phe 
    130                 135                 140                 


Ser Gly Phe Pro Ser Phe Gly Ser Gly Phe Ser Ser Phe Asp Thr Gly 
145                 150                 155                 160 


Phe Thr Ser Phe Gly Ser Leu Gly His Gly Gly Leu Thr Ser Phe Ser 
                165                 170                 175     


Ser Thr Ser Phe Gly Gly Ser Gly Met Gly Asn Phe Lys Ser Ile Ser 
            180                 185                 190         


Thr Ser Thr Lys Met Val Asn Gly Arg Lys Ile Thr Thr Lys Arg Ile 
        195                 200                 205             


Val Glu Asn Gly Gln Glu Arg Val Glu Val Glu Glu Asp Gly Gln Leu 
    210                 215                 220                 


Lys Ser Leu Thr Ile Asn Gly Lys Glu Gln Leu Leu Arg Leu Asp Asn 
225                 230                 235                 240 


Lys 
    


<210>  3160
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB7__Homo_sapiens__NP_660157

<400>  3160

Met Val Asp Tyr Tyr Glu Val Leu Gly Leu Gln Arg Tyr Ala Ser Pro 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ala Tyr His Lys Val Ala Leu Lys Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Glu Asn Lys Glu Glu Ala Glu Arg Lys Phe Lys Glu 
        35                  40                  45              


Val Ala Glu Ala Tyr Glu Val Leu Ser Asn Asp Glu Lys Arg Asp Ile 
    50                  55                  60                  


Tyr Asp Lys Tyr Gly Thr Glu Gly Leu Asn Gly Gly Gly Ser His Phe 
65                  70                  75                  80  


Asp Asp Glu Cys Glu Tyr Gly Phe Thr Phe His Lys Pro Asp Asp Val 
                85                  90                  95      


Phe Lys Glu Ile Phe His Glu Arg Asp Pro Phe Ser Phe His Phe Phe 
            100                 105                 110         


Glu Asp Ser Leu Glu Asp Leu Leu Asn Arg Pro Gly Ser Ser Tyr Gly 
        115                 120                 125             


Asn Arg Asn Arg Asp Ala Gly Tyr Phe Phe Ser Thr Ala Ser Glu Tyr 
    130                 135                 140                 


Pro Ile Phe Glu Lys Phe Ser Ser Tyr Asp Thr Gly Tyr Thr Ser Gln 
145                 150                 155                 160 


Gly Ser Leu Gly His Glu Gly Leu Thr Ser Phe Ser Ser Leu Ala Phe 
                165                 170                 175     


Asp Asn Ser Gly Met Asp Asn Tyr Ile Ser Val Thr Thr Ser Asp Lys 
            180                 185                 190         


Ile Val Asn Gly Arg Asn Ile Asn Thr Lys Lys Ile Ile Glu Ser Asp 
        195                 200                 205             


Gln Glu Arg Glu Ala Glu Asp Asn Gly Glu Leu Thr Phe Phe Leu Val 
    210                 215                 220                 


Asn Ser Val Ala Asn Glu Glu Gly Phe Ala Lys Glu Cys Ser Trp Arg 
225                 230                 235                 240 


Thr Gln Ser Phe Asn Asn Tyr Ser Pro Asn Ser His Ser Ser Lys His 
                245                 250                 255     


Val Ser Gln Tyr Thr Phe Val Asp Asn Asp Glu Gly Gly Ile Ser Trp 
            260                 265                 270         


Val Thr Ser Asn Arg Asp Pro Pro Ile Phe Ser Ala Gly Val Lys Glu 
        275                 280                 285             


Gly Gly Lys Arg Lys Lys Lys Lys Arg Lys Glu Val Gln Lys Lys Ser 
    290                 295                 300                 


Thr Lys Arg Asn Cys 
305                 


<210>  3161
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB8__Homo_sapiens__NP_699161

<400>  3161

Met Ala Asn Tyr Tyr Glu Val Leu Gly Val Gln Ala Ser Ala Ser Pro 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Arg Trp His Pro 
            20                  25                  30          


Asp Lys Asn Pro Asp Asn Lys Glu Glu Ala Glu Lys Lys Phe Lys Leu 
        35                  40                  45              


Val Ser Glu Ala Tyr Glu Val Leu Ser Asp Ser Lys Lys Arg Ser Leu 
    50                  55                  60                  


Tyr Asp Arg Ala Gly Cys Asp Ser Trp Arg Ala Gly Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Pro Tyr His Ser Pro Phe Asp Thr Gly Tyr Thr Phe Arg Asn Pro 
                85                  90                  95      


Glu Asp Ile Phe Arg Glu Phe Phe Gly Gly Leu Asp Pro Phe Ser Phe 
            100                 105                 110         


Glu Phe Trp Asp Ser Pro Phe Asn Ser Asp Arg Gly Gly Arg Gly His 
        115                 120                 125             


Gly Leu Arg Gly Ala Phe Ser Ala Gly Phe Gly Glu Phe Pro Ala Phe 
    130                 135                 140                 


Met Glu Ala Phe Ser Ser Phe Asn Met Leu Gly Cys Ser Gly Gly Ser 
145                 150                 155                 160 


His Thr Thr Phe Ser Ser Thr Ser Phe Gly Gly Ser Ser Ser Gly Ser 
                165                 170                 175     


Ser Gly Phe Lys Ser Val Met Ser Ser Thr Glu Met Ile Asn Gly His 
            180                 185                 190         


Lys Val Thr Thr Lys Arg Ile Val Glu Asn Gly Gln Glu Arg Val Glu 
        195                 200                 205             


Val Glu Glu Asp Gly Gln Leu Lys Ser Val Thr Val Asn Gly Lys Glu 
    210                 215                 220                 


Gln Leu Lys Trp Met Asp Ser Lys 
225                 230         


<210>  3162
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJB9__Homo_sapiens__NP_036460

<400>  3162

Met Ala Thr Pro Gln Ser Ile Phe Ile Phe Ala Ile Cys Ile Leu Met 
1               5                   10                  15      


Ile Thr Glu Leu Ile Leu Ala Ser Lys Ser Tyr Tyr Asp Ile Leu Gly 
            20                  25                  30          


Val Pro Lys Ser Ala Ser Glu Arg Gln Ile Lys Lys Ala Phe His Lys 
        35                  40                  45              


Leu Ala Met Lys Tyr His Pro Asp Lys Asn Lys Ser Pro Asp Ala Glu 
    50                  55                  60                  


Ala Lys Phe Arg Glu Ile Ala Glu Ala Tyr Glu Thr Leu Ser Asp Ala 
65                  70                  75                  80  


Asn Arg Arg Lys Glu Tyr Asp Thr Leu Gly His Ser Ala Phe Thr Ser 
                85                  90                  95      


Gly Lys Gly Gln Arg Gly Ser Gly Ser Ser Phe Glu Gln Ser Phe Asn 
            100                 105                 110         


Phe Asn Phe Asp Asp Leu Phe Lys Asp Phe Gly Phe Phe Gly Gln Asn 
        115                 120                 125             


Gln Asn Thr Gly Ser Lys Lys Arg Phe Glu Asn His Phe Gln Thr Arg 
    130                 135                 140                 


Gln Asp Gly Gly Ser Ser Arg Gln Arg His His Phe Gln Glu Phe Ser 
145                 150                 155                 160 


Phe Gly Gly Gly Leu Phe Asp Asp Met Phe Glu Asp Met Glu Lys Met 
                165                 170                 175     


Phe Ser Phe Ser Gly Phe Asp Ser Thr Asn Gln His Thr Val Gln Thr 
            180                 185                 190         


Glu Asn Arg Phe His Gly Ser Ser Lys His Cys Arg Thr Val Thr Gln 
        195                 200                 205             


Arg Arg Gly Asn Met Val Thr Thr Tyr Thr Asp Cys Ser Gly Gln 
    210                 215                 220             


<210>  3163
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC10__Homo_sapiens__NP_001258510

<400>  3163

Met Gly Val Trp Leu Asn Lys Asp Asp Tyr Ile Arg Asp Leu Lys Arg 
1               5                   10                  15      


Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val Gly Thr 
            20                  25                  30          


Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser 
        35                  40                  45              


Arg Glu Ile Arg Gln Ala Phe Lys Lys Leu Ala Leu Lys Leu His Pro 
    50                  55                  60                  


Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asp Phe Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr 
                85                  90                  95      


Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr 
            100                 105                 110         


Glu Ser Trp Asn Tyr Tyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp 
        115                 120                 125             


Pro Glu Ile Ile Thr Leu Glu Arg Arg Glu Phe Asp Ala Ala Val Asn 
    130                 135                 140                 


Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His 
145                 150                 155                 160 


Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp 
                165                 170                 175     


Gly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu 
            180                 185                 190         


Cys Arg Met Lys Gly Val Asn Ser Tyr Pro Ser Leu Phe Ile Phe Arg 
        195                 200                 205             


Ser Gly Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser 
    210                 215                 220                 


Leu Val Ser Phe Ala Met Gln His Val Arg Ser Thr Val Thr Glu Leu 
225                 230                 235                 240 


Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Phe Ala Ala Gly 
                245                 250                 255     


Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys Leu Thr 
            260                 265                 270         


Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Phe Leu Asn Ser Leu 
        275                 280                 285             


Asp Ala Lys Glu Ile Tyr Leu Glu Val Ile His Asn Leu Pro Asp Phe 
    290                 295                 300                 


Glu Leu Leu Ser Ala Asn Thr Leu Glu Asp Arg Leu Ala His His Arg 
305                 310                 315                 320 


Trp Leu Leu Phe Phe His Phe Gly Lys Asn Glu Asn Ser Asn Asp Pro 
                325                 330                 335     


Glu Leu Lys Lys Leu Lys Thr Leu Leu Lys Asn Asp His Ile Gln Val 
            340                 345                 350         


Gly Arg Phe Asp Cys Ser Ser Ala Pro Asp Ile Cys Ser Asn Leu Tyr 
        355                 360                 365             


Val Phe Gln Pro Ser Leu Ala Val Phe Lys Gly Gln Gly Thr Lys Glu 
    370                 375                 380                 


Tyr Glu Ile His His Gly Lys Lys Ile Leu Tyr Asp Ile Leu Ala Phe 
385                 390                 395                 400 


Ala Lys Glu Ser Val Asn Ser His Val Thr Thr Leu Gly Pro Gln Asn 
                405                 410                 415     


Phe Pro Ala Asn Asp Lys Glu Pro Trp Leu Val Asp Phe Phe Ala Pro 
            420                 425                 430         


Trp Cys Pro Pro Cys Arg Ala Leu Leu Pro Glu Leu Arg Arg Ala Ser 
        435                 440                 445             


Asn Leu Leu Tyr Gly Gln Leu Lys Phe Gly Thr Leu Asp Cys Thr Val 
    450                 455                 460                 


His Glu Gly Leu Cys Asn Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr 
465                 470                 475                 480 


Val Val Phe Asn Gln Ser Asn Ile His Glu Tyr Glu Gly His His Ser 
                485                 490                 495     


Ala Glu Gln Ile Leu Glu Phe Ile Glu Asp Leu Met Asn Pro Ser Val 
            500                 505                 510         


Val Ser Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr Gln Arg Lys 
        515                 520                 525             


His Asn Glu Val Trp Met Val Asp Phe Tyr Ser Pro Trp Cys His Pro 
    530                 535                 540                 


Cys Gln Val Leu Met Pro Glu Trp Lys Arg Met Ala Arg Thr Leu Thr 
545                 550                 555                 560 


Gly Leu Ile Asn Val Gly Ser Ile Asp Cys Gln Gln Tyr His Ser Phe 
                565                 570                 575     


Cys Ala Gln Glu Asn Val Gln Arg Tyr Pro Glu Ile Arg Phe Phe Pro 
            580                 585                 590         


Pro Lys Ser Asn Lys Ala Tyr His Tyr His Ser Tyr Asn Gly Trp Asn 
        595                 600                 605             


Arg Asp Ala Tyr Ser Leu Arg Ile Trp Gly Leu Gly Phe Leu Pro Gln 
    610                 615                 620                 


Val Ser Thr Asp Leu Thr Pro Gln Thr Phe Ser Glu Lys Val Leu Gln 
625                 630                 635                 640 


Gly Lys Asn His Trp Val Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro 
                645                 650                 655     


Cys Gln Asn Phe Ala Pro Glu Phe Glu Leu Leu Ala Arg Met Ile Lys 
            660                 665                 670         


Gly Lys Val Lys Ala Gly Lys Val Asp Cys Gln Ala Tyr Ala Gln Thr 
        675                 680                 685             


Cys Gln Lys Ala Gly Ile Arg Ala Tyr Pro Thr Val Lys Phe Tyr Phe 
    690                 695                 700                 


Tyr Glu Arg Ala Lys Arg Asn Phe Gln Glu Glu Gln Ile Asn Thr Arg 
705                 710                 715                 720 


Asp Ala Lys Ala Ile Ala Ala Leu Ile Ser Glu Lys Leu Glu Thr Leu 
                725                 730                 735     


Arg Asn Gln Gly Lys Arg Asn Lys Asp Glu Leu 
            740                 745         


<210>  3164
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC12__Homo_sapiens__NP_068572

<400>  3164

Met Asp Ala Ile Leu Asn Tyr Arg Ser Glu Asp Thr Glu Asp Tyr Tyr 
1               5                   10                  15      


Thr Leu Leu Gly Cys Asp Glu Leu Ser Ser Val Glu Gln Ile Leu Ala 
            20                  25                  30          


Glu Phe Lys Val Arg Ala Leu Glu Cys His Pro Asp Lys His Pro Glu 
        35                  40                  45              


Asn Pro Lys Ala Val Glu Thr Phe Gln Lys Leu Gln Lys Ala Lys Glu 
    50                  55                  60                  


Ile Leu Thr Asn Glu Glu Ser Arg Ala Arg Tyr Asp His Trp Arg Arg 
65                  70                  75                  80  


Ser Gln Met Ser Met Pro Phe Gln Gln Trp Glu Ala Leu Asn Asp Ser 
                85                  90                  95      


Val Lys Thr Ser Met His Trp Val Val Arg Gly Lys Lys Asp Leu Met 
            100                 105                 110         


Leu Glu Glu Ser Asp Lys Thr His Thr Thr Lys Met Glu Asn Glu Glu 
        115                 120                 125             


Cys Asn Glu Gln Arg Glu Arg Lys Lys Glu Glu Leu Ala Ser Thr Ala 
    130                 135                 140                 


Glu Lys Thr Glu Gln Lys Glu Pro Lys Pro Leu Glu Lys Ser Val Ser 
145                 150                 155                 160 


Pro Gln Asn Ser Asp Ser Ser Gly Phe Ala Asp Val Asn Gly Trp His 
                165                 170                 175     


Leu Arg Phe Arg Trp Ser Lys Asp Ala Pro Ser Glu Leu Leu Arg Lys 
            180                 185                 190         


Phe Arg Asn Tyr Glu Ile 
        195             


<210>  3165
<211>  2243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC13__Homo_sapiens__NP_056083

<400>  3165

Met Asn Ile Ile Arg Glu Asn Lys Asp Leu Ala Cys Phe Tyr Thr Thr 
1               5                   10                  15      


Lys His Ser Trp Arg Gly Lys Tyr Lys Arg Val Phe Ser Val Gly Thr 
            20                  25                  30          


His Ala Ile Thr Thr Tyr Asn Pro Asn Thr Leu Glu Val Thr Asn Gln 
        35                  40                  45              


Trp Pro Tyr Gly Asp Ile Cys Ser Ile Ser Pro Val Gly Lys Gly Gln 
    50                  55                  60                  


Gly Thr Glu Phe Asn Leu Thr Phe Arg Lys Gly Ser Gly Lys Lys Ser 
65                  70                  75                  80  


Glu Thr Leu Lys Phe Ser Thr Glu His Arg Thr Glu Leu Leu Thr Glu 
                85                  90                  95      


Ala Leu Arg Phe Arg Thr Asp Phe Ser Glu Gly Lys Ile Thr Gly Arg 
            100                 105                 110         


Arg Tyr Asn Cys Tyr Lys His His Trp Ser Asp Ser Arg Lys Pro Val 
        115                 120                 125             


Ile Leu Glu Val Thr Pro Gly Gly Phe Asp Gln Ile Asn Pro Ala Thr 
    130                 135                 140                 


Asn Arg Val Leu Cys Ser Tyr Asp Tyr Arg Asn Ile Glu Gly Phe Val 
145                 150                 155                 160 


Asp Leu Ser Asp Tyr Gln Gly Gly Phe Cys Ile Leu Tyr Gly Gly Phe 
                165                 170                 175     


Ser Arg Leu His Leu Phe Ala Ser Glu Gln Arg Glu Glu Ile Ile Lys 
            180                 185                 190         


Ser Ala Ile Asp His Ala Gly Asn Tyr Ile Gly Ile Ser Leu Arg Ile 
        195                 200                 205             


Arg Lys Glu Pro Leu Glu Phe Glu Gln Tyr Leu Asn Leu Arg Phe Gly 
    210                 215                 220                 


Lys Tyr Ser Thr Asp Glu Ser Ile Thr Ser Leu Ala Glu Phe Val Val 
225                 230                 235                 240 


Gln Lys Ile Ser Pro Arg His Ser Glu Pro Val Lys Arg Val Leu Ala 
                245                 250                 255     


Leu Thr Glu Thr Cys Leu Val Glu Arg Asp Pro Ala Thr Tyr Asn Ile 
            260                 265                 270         


Ala Thr Leu Lys Pro Leu Gly Glu Val Phe Ala Leu Val Cys Asp Ser 
        275                 280                 285             


Glu Asn Pro Gln Leu Phe Thr Ile Glu Phe Ile Lys Gly Gln Val Arg 
    290                 295                 300                 


Lys Tyr Ser Ser Thr Glu Arg Asp Ser Leu Leu Ala Ser Leu Leu Asp 
305                 310                 315                 320 


Gly Val Arg Ala Ser Gly Asn Arg Asp Val Cys Val Lys Met Thr Pro 
                325                 330                 335     


Thr His Lys Gly Gln Arg Trp Gly Leu Leu Ser Met Pro Val Asp Glu 
            340                 345                 350         


Glu Val Glu Ser Leu His Leu Arg Phe Leu Ala Thr Pro Pro Asn Gly 
        355                 360                 365             


Asn Phe Ala Asp Ala Val Phe Arg Phe Asn Ala Asn Ile Ser Tyr Ser 
    370                 375                 380                 


Gly Val Leu His Ala Val Thr Gln Asp Gly Leu Phe Ser Glu Asn Lys 
385                 390                 395                 400 


Glu Lys Leu Ile Asn Asn Ala Ile Thr Ala Leu Leu Ser Gln Glu Gly 
                405                 410                 415     


Asp Val Val Ala Ser Asn Ala Glu Leu Glu Ser Gln Phe Gln Ala Val 
            420                 425                 430         


Arg Arg Leu Val Ala Ser Lys Ala Gly Phe Leu Ala Phe Thr Gln Leu 
        435                 440                 445             


Pro Lys Phe Arg Glu Arg Leu Gly Val Lys Val Val Lys Ala Leu Lys 
    450                 455                 460                 


Arg Ser Asn Asn Gly Ile Ile His Ala Ala Val Asp Met Leu Cys Ala 
465                 470                 475                 480 


Leu Met Cys Pro Met His Asp Asp Tyr Asp Leu Arg Gln Glu Gln Leu 
                485                 490                 495     


Asn Lys Ala Ser Leu Leu Ser Ser Lys Lys Phe Leu Glu Asn Leu Leu 
            500                 505                 510         


Glu Lys Phe Asn Ser His Val Asp His Gly Thr Gly Ala Leu Val Ile 
        515                 520                 525             


Ser Ser Leu Leu Asp Phe Leu Thr Phe Ala Leu Cys Ala Pro Tyr Ser 
    530                 535                 540                 


Glu Thr Thr Glu Gly Gln Gln Phe Asp Met Leu Leu Glu Met Val Ala 
545                 550                 555                 560 


Ser Asn Gly Arg Thr Leu Phe Lys Leu Phe Gln His Pro Ser Met Ala 
                565                 570                 575     


Ile Ile Lys Gly Ala Gly Leu Val Met Lys Ala Ile Ile Glu Glu Gly 
            580                 585                 590         


Asp Lys Glu Ile Ala Thr Lys Met Gln Glu Leu Ala Leu Ser Glu Gly 
        595                 600                 605             


Ala Leu Pro Arg His Leu His Thr Ala Met Phe Thr Ile Ser Ser Asp 
    610                 615                 620                 


Gln Arg Met Leu Thr Asn Arg Gln Leu Ser Arg His Leu Val Gly Leu 
625                 630                 635                 640 


Trp Thr Ala Asp Asn Ala Thr Ala Thr Asn Leu Leu Lys Arg Ile Leu 
                645                 650                 655     


Pro Pro Gly Leu Leu Ala Tyr Leu Glu Ser Ser Asp Leu Val Pro Glu 
            660                 665                 670         


Lys Asp Ala Asp Arg Met His Val Arg Asp Asn Val Lys Ile Ala Met 
        675                 680                 685             


Asp Gln Tyr Gly Lys Phe Asn Lys Val Pro Glu Trp Gln Arg Leu Ala 
    690                 695                 700                 


Gly Lys Ala Ala Lys Glu Val Glu Lys Phe Ala Lys Glu Lys Val Asp 
705                 710                 715                 720 


Leu Val Leu Met His Trp Arg Asp Arg Met Gly Ile Ala Gln Lys Glu 
                725                 730                 735     


Asn Ile Asn Gln Lys Pro Val Val Leu Arg Lys Arg Arg Gln Arg Ile 
            740                 745                 750         


Lys Ile Glu Ala Asn Trp Asp Leu Phe Tyr Tyr Arg Phe Gly Gln Asp 
        755                 760                 765             


His Ala Arg Ser Asn Leu Ile Trp Asn Phe Lys Thr Arg Glu Glu Leu 
    770                 775                 780                 


Lys Asp Thr Leu Glu Ser Glu Met Arg Ala Phe Asn Ile Asp Arg Glu 
785                 790                 795                 800 


Leu Gly Ser Ala Asn Val Ile Ser Trp Asn His His Glu Phe Glu Val 
                805                 810                 815     


Lys Tyr Glu Cys Leu Ala Glu Glu Ile Lys Ile Gly Asp Tyr Tyr Leu 
            820                 825                 830         


Arg Leu Leu Leu Glu Glu Asp Glu Asn Glu Glu Ser Gly Ser Ile Lys 
        835                 840                 845             


Arg Ser Tyr Glu Phe Phe Asn Glu Leu Tyr His Arg Phe Leu Leu Thr 
    850                 855                 860                 


Pro Lys Val Asn Met Lys Cys Leu Cys Leu Gln Ala Leu Ala Ile Val 
865                 870                 875                 880 


Tyr Gly Arg Cys His Glu Glu Ile Gly Pro Phe Thr Asp Thr Arg Tyr 
                885                 890                 895     


Ile Ile Gly Met Leu Glu Arg Cys Thr Asp Lys Leu Glu Arg Asp Arg 
            900                 905                 910         


Leu Ile Leu Phe Leu Asn Lys Leu Ile Leu Asn Lys Lys Asn Val Lys 
        915                 920                 925             


Asp Leu Met Asp Ser Asn Gly Ile Arg Ile Leu Val Asp Leu Leu Thr 
    930                 935                 940                 


Leu Ala His Leu His Val Ser Arg Ala Thr Val Pro Leu Gln Ser Asn 
945                 950                 955                 960 


Val Ile Glu Ala Ala Pro Asp Met Lys Arg Glu Ser Glu Lys Glu Trp 
                965                 970                 975     


Tyr Phe Gly Asn Ala Asp Lys Glu Arg Ser Gly Pro Tyr Gly Phe His 
            980                 985                 990         


Glu Met Gln Glu Leu Trp Thr Lys  Gly Met Leu Asn Ala  Lys Thr Arg 
        995                 1000                 1005             


Cys Trp  Ala Gln Gly Met Asp  Gly Trp Arg Pro Leu  Gln Ser Ile 
    1010                 1015                 1020             


Pro Gln  Leu Lys Trp Cys Leu  Leu Ala Ser Gly Gln  Ala Val Leu 
    1025                 1030                 1035             


Asn Glu  Thr Asp Leu Ala Thr  Leu Ile Leu Asn Met  Leu Ile Thr 
    1040                 1045                 1050             


Met Cys  Gly Tyr Phe Pro Ser  Arg Asp Gln Asp Asn  Ala Ile Ile 
    1055                 1060                 1065             


Arg Pro  Leu Pro Lys Val Lys  Arg Leu Leu Ser Asp  Ser Thr Cys 
    1070                 1075                 1080             


Leu Pro  His Ile Ile Gln Leu  Leu Leu Thr Phe Asp  Pro Ile Leu 
    1085                 1090                 1095             


Val Glu  Lys Val Ala Ile Leu  Leu Tyr His Ile Met  Gln Asp Asn 
    1100                 1105                 1110             


Pro Gln  Leu Pro Arg Leu Tyr  Leu Ser Gly Val Phe  Phe Phe Ile 
    1115                 1120                 1125             


Met Met  Tyr Thr Gly Ser Asn  Val Leu Pro Val Ala  Arg Phe Leu 
    1130                 1135                 1140             


Lys Tyr  Thr His Thr Lys Gln  Ala Phe Lys Ser Glu  Glu Thr Lys 
    1145                 1150                 1155             


Gly Gln  Asp Ile Phe Gln Arg  Ser Ile Leu Gly His  Ile Leu Pro 
    1160                 1165                 1170             


Glu Ala  Met Val Cys Tyr Leu  Glu Asn Tyr Glu Pro  Glu Lys Phe 
    1175                 1180                 1185             


Ser Glu  Ile Phe Leu Gly Glu  Phe Asp Thr Pro Glu  Ala Ile Trp 
    1190                 1195                 1200             


Ser Ser  Glu Met Arg Arg Leu  Met Ile Glu Lys Ile  Ala Ala His 
    1205                 1210                 1215             


Leu Ala  Asp Phe Thr Pro Arg  Leu Gln Ser Asn Thr  Arg Ala Leu 
    1220                 1225                 1230             


Tyr Gln  Tyr Cys Pro Ile Pro  Ile Ile Asn Tyr Pro  Gln Leu Glu 
    1235                 1240                 1245             


Asn Glu  Leu Phe Cys Asn Ile  Tyr Tyr Leu Lys Gln  Leu Cys Asp 
    1250                 1255                 1260             


Thr Leu  Arg Phe Pro Asp Trp  Pro Ile Lys Asp Pro  Val Lys Leu 
    1265                 1270                 1275             


Leu Lys  Asp Thr Leu Asp Ala  Trp Lys Lys Glu Val  Glu Lys Lys 
    1280                 1285                 1290             


Pro Pro  Met Met Ser Ile Asp  Asp Ala Tyr Glu Val  Leu Asn Leu 
    1295                 1300                 1305             


Pro Gln  Gly Gln Gly Pro His  Asp Glu Ser Lys Ile  Arg Lys Ala 
    1310                 1315                 1320             


Tyr Phe  Arg Leu Ala Gln Lys  Tyr His Pro Asp Lys  Asn Pro Glu 
    1325                 1330                 1335             


Gly Arg  Asp Met Phe Glu Lys  Val Asn Lys Ala Tyr  Glu Phe Leu 
    1340                 1345                 1350             


Cys Thr  Lys Ser Ala Lys Ile  Val Asp Gly Pro Asp  Pro Glu Asn 
    1355                 1360                 1365             


Ile Ile  Leu Ile Leu Lys Thr  Gln Ser Ile Leu Phe  Asn Arg His 
    1370                 1375                 1380             


Lys Glu  Asp Leu Gln Pro Tyr  Lys Tyr Ala Gly Tyr  Pro Met Leu 
    1385                 1390                 1395             


Ile Arg  Thr Ile Thr Met Glu  Thr Ser Asp Asp Leu  Leu Phe Ser 
    1400                 1405                 1410             


Lys Glu  Ser Pro Leu Leu Pro  Ala Ala Thr Glu Leu  Ala Phe His 
    1415                 1420                 1425             


Thr Val  Asn Cys Ser Ala Leu  Asn Ala Glu Glu Leu  Arg Arg Glu 
    1430                 1435                 1440             


Asn Gly  Leu Glu Val Leu Gln  Glu Ala Phe Ser Arg  Cys Val Ala 
    1445                 1450                 1455             


Val Leu  Thr Arg Ala Ser Lys  Pro Ser Asp Met Ser  Val Gln Val 
    1460                 1465                 1470             


Cys Gly  Tyr Ile Ser Lys Cys  Tyr Ser Val Ala Ala  Gln Phe Glu 
    1475                 1480                 1485             


Glu Cys  Arg Glu Lys Ile Thr  Glu Met Pro Ser Ile  Ile Lys Asp 
    1490                 1495                 1500             


Leu Cys  Arg Val Leu Tyr Phe  Gly Lys Ser Ile Pro  Arg Val Ala 
    1505                 1510                 1515             


Ala Leu  Gly Val Glu Cys Val  Ser Ser Phe Ala Val  Asp Phe Trp 
    1520                 1525                 1530             


Leu Gln  Thr His Leu Phe Gln  Ala Gly Ile Leu Trp  Tyr Leu Leu 
    1535                 1540                 1545             


Gly Phe  Leu Phe Asn Tyr Asp  Tyr Thr Leu Glu Glu  Ser Gly Ile 
    1550                 1555                 1560             


Gln Lys  Ser Glu Glu Thr Asn  Gln Gln Glu Val Ala  Asn Ser Leu 
    1565                 1570                 1575             


Ala Lys  Leu Ser Val His Ala  Leu Ser Arg Leu Gly  Gly Tyr Leu 
    1580                 1585                 1590             


Ala Glu  Glu Gln Ala Thr Pro  Glu Asn Pro Thr Ile  Arg Lys Ser 
    1595                 1600                 1605             


Leu Ala  Gly Met Leu Thr Pro  Tyr Val Ala Arg Lys  Leu Ala Val 
    1610                 1615                 1620             


Ala Ser  Val Thr Glu Ile Leu  Lys Met Leu Asn Ser  Asn Thr Glu 
    1625                 1630                 1635             


Ser Pro  Tyr Leu Ile Trp Asn  Asn Ser Thr Arg Ala  Glu Leu Leu 
    1640                 1645                 1650             


Glu Phe  Leu Glu Ser Gln Gln  Glu Asn Met Ile Lys  Lys Gly Asp 
    1655                 1660                 1665             


Cys Asp  Lys Thr Tyr Gly Ser  Glu Phe Val Tyr Ser  Asp His Ala 
    1670                 1675                 1680             


Lys Glu  Leu Ile Val Gly Glu  Ile Phe Val Arg Val  Tyr Asn Glu 
    1685                 1690                 1695             


Val Pro  Thr Phe Gln Leu Glu  Val Pro Lys Ala Phe  Ala Ala Ser 
    1700                 1705                 1710             


Leu Leu  Asp Tyr Ile Gly Ser  Gln Ala Gln Tyr Leu  His Thr Phe 
    1715                 1720                 1725             


Met Ala  Ile Thr His Ala Ala  Lys Val Glu Ser Glu  Gln His Gly 
    1730                 1735                 1740             


Asp Arg  Leu Pro Arg Val Glu  Met Ala Leu Glu Ala  Leu Arg Asn 
    1745                 1750                 1755             


Val Ile  Lys Tyr Asn Pro Gly  Ser Glu Ser Glu Cys  Ile Gly His 
    1760                 1765                 1770             


Phe Lys  Leu Ile Phe Ser Leu  Leu Arg Val His Gly  Ala Gly Gln 
    1775                 1780                 1785             


Val Gln  Gln Leu Ala Leu Glu  Val Val Asn Ile Val  Thr Ser Asn 
    1790                 1795                 1800             


Gln Asp  Cys Val Asn Asn Ile  Ala Glu Ser Met Val  Leu Ser Ser 
    1805                 1810                 1815             


Leu Leu  Ala Leu Leu His Ser  Leu Pro Ser Ser Arg  Gln Leu Val 
    1820                 1825                 1830             


Leu Glu  Thr Leu Tyr Ala Leu  Thr Ser Ser Thr Lys  Ile Ile Lys 
    1835                 1840                 1845             


Glu Ala  Met Ala Lys Gly Ala  Leu Ile Tyr Leu Leu  Asp Met Phe 
    1850                 1855                 1860             


Cys Asn  Ser Thr His Pro Gln  Val Arg Ala Gln Thr  Ala Glu Leu 
    1865                 1870                 1875             


Phe Ala  Lys Met Thr Ala Asp  Lys Leu Ile Gly Pro  Lys Val Arg 
    1880                 1885                 1890             


Ile Thr  Leu Met Lys Phe Leu  Pro Ser Val Phe Met  Asp Ala Met 
    1895                 1900                 1905             


Arg Asp  Asn Pro Glu Ala Ala  Val His Ile Phe Glu  Gly Thr His 
    1910                 1915                 1920             


Glu Asn  Pro Glu Leu Ile Trp  Asn Asp Asn Ser Arg  Asp Lys Val 
    1925                 1930                 1935             


Ser Thr  Thr Val Arg Glu Met  Met Leu Glu His Phe  Lys Asn Gln 
    1940                 1945                 1950             


Gln Asp  Asn Pro Glu Ala Asn  Trp Lys Leu Pro Glu  Asp Phe Ala 
    1955                 1960                 1965             


Val Val  Phe Gly Glu Ala Glu  Gly Glu Leu Ala Val  Gly Gly Val 
    1970                 1975                 1980             


Phe Leu  Arg Ile Phe Ile Ala  Gln Pro Ala Trp Val  Leu Arg Lys 
    1985                 1990                 1995             


Pro Arg  Glu Phe Leu Ile Ala  Leu Leu Glu Lys Leu  Thr Glu Leu 
    2000                 2005                 2010             


Leu Glu  Lys Asn Asn Pro His  Gly Glu Thr Leu Glu  Thr Leu Thr 
    2015                 2020                 2025             


Met Ala  Thr Val Cys Leu Phe  Ser Ala Gln Pro Gln  Leu Ala Asp 
    2030                 2035                 2040             


Gln Val  Pro Pro Leu Gly His  Leu Pro Lys Val Ile  Gln Ala Met 
    2045                 2050                 2055             


Asn His  Arg Asn Asn Ala Ile  Pro Lys Ser Ala Ile  Arg Val Ile 
    2060                 2065                 2070             


His Ala  Leu Ser Glu Asn Glu  Leu Cys Val Arg Ala  Met Ala Ser 
    2075                 2080                 2085             


Leu Glu  Thr Ile Gly Pro Leu  Met Asn Gly Met Lys  Lys Arg Ala 
    2090                 2095                 2100             


Asp Thr  Val Gly Leu Ala Cys  Glu Ala Ile Asn Arg  Met Phe Gln 
    2105                 2110                 2115             


Lys Glu  Gln Ser Glu Leu Val  Ala Gln Ala Leu Lys  Ala Asp Leu 
    2120                 2125                 2130             


Val Pro  Tyr Leu Leu Lys Leu  Leu Glu Gly Ile Gly  Leu Glu Asn 
    2135                 2140                 2145             


Leu Asp  Ser Pro Ala Ala Thr  Lys Ala Gln Ile Val  Lys Ala Leu 
    2150                 2155                 2160             


Lys Ala  Met Thr Arg Ser Leu  Gln Tyr Gly Glu Gln  Val Asn Glu 
    2165                 2170                 2175             


Ile Leu  Cys Arg Ser Ser Val  Trp Ser Ala Phe Lys  Asp Gln Lys 
    2180                 2185                 2190             


His Asp  Leu Phe Ile Ser Glu  Ser Gln Thr Ala Gly  Tyr Leu Thr 
    2195                 2200                 2205             


Gly Pro  Gly Val Ala Gly Tyr  Leu Thr Ala Gly Thr  Ser Thr Ser 
    2210                 2215                 2220             


Val Met  Ser Asn Leu Pro Pro  Pro Val Asp His Glu  Ala Gly Asp 
    2225                 2230                 2235             


Leu Gly  Tyr Gln Thr 
    2240             


<210>  3166
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC14__Homo_sapiens__NP_115740

<400>  3166

Met Ala Gln Lys His Pro Gly Glu Arg Gly Leu Tyr Gly Ala His His 
1               5                   10                  15      


Ser Gly Gly Ala Ser Leu Arg Thr Leu Gly Pro Ser Val Asp Pro Glu 
            20                  25                  30          


Ile Pro Ser Phe Ser Gly Leu Arg Asp Ser Ala Gly Thr Ala Pro Asn 
        35                  40                  45              


Gly Thr Arg Cys Leu Thr Glu His Ser Gly Pro Lys His Thr Gln His 
    50                  55                  60                  


Pro Asn Pro Ala His Trp Leu Asp Pro Ser His Gly Pro Pro Gly Gly 
65                  70                  75                  80  


Pro Gly Pro Pro Arg Asp Ala Glu Asp Pro Asp Gln Ser Glu Thr Ser 
                85                  90                  95      


Ser Glu Glu Glu Ser Gly Val Asp Gln Glu Leu Ser Lys Glu Asn Glu 
            100                 105                 110         


Thr Gly Asn Gln Lys Asp Gly Asn Ser Phe Leu Ser Ile Pro Ser Ala 
        115                 120                 125             


Cys Asn Cys Gln Gly Thr Pro Gly Ile Pro Glu Gly Pro Tyr Ser Glu 
    130                 135                 140                 


Gly Gly Asn Gly Ser Ser Ser Asn Phe Cys His His Cys Thr Ser Pro 
145                 150                 155                 160 


Ala Leu Gly Glu Asp Glu Leu Glu Glu Glu Tyr Asp Asp Glu Glu Ser 
                165                 170                 175     


Leu Lys Phe Pro Ser Asp Phe Ser Arg Val Ser Ser Gly Lys Lys Pro 
            180                 185                 190         


Pro Ser Arg Arg Gln Arg His Arg Phe Pro Thr Lys Glu Asp Thr Arg 
        195                 200                 205             


Glu Gly Gly Arg Arg Asp Pro Arg Ser Pro Gly Arg His Arg Leu Gly 
    210                 215                 220                 


Arg Lys Arg Ser Gln Ala Asp Lys Arg Lys Gly Leu Gly Leu Trp Gly 
225                 230                 235                 240 


Ala Glu Glu Leu Cys Gln Leu Gly Gln Ala Gly Phe Trp Trp Leu Ile 
                245                 250                 255     


Glu Leu Leu Val Leu Val Gly Glu Tyr Val Glu Thr Cys Gly His Leu 
            260                 265                 270         


Ile Tyr Ala Cys Arg Gln Leu Lys Ser Ser Asp Leu Asp Leu Phe Arg 
        275                 280                 285             


Val Trp Met Gly Val Trp Thr Gly Arg Leu Gly Gly Trp Ala Gln Val 
    290                 295                 300                 


Met Phe Gln Phe Leu Ser Gln Gly Phe Tyr Cys Gly Val Gly Leu Phe 
305                 310                 315                 320 


Thr Arg Phe Leu Lys Leu Leu Gly Ala Leu Leu Leu Leu Ala Leu Ala 
                325                 330                 335     


Leu Phe Leu Gly Phe Leu Gln Leu Gly Trp Arg Phe Leu Val Gly Leu 
            340                 345                 350         


Gly Asp Arg Leu Gly Trp Arg Asp Lys Ala Thr Trp Leu Phe Ser Trp 
        355                 360                 365             


Leu Asp Ser Pro Ala Leu Gln Arg Cys Leu Thr Leu Leu Arg Asp Ser 
    370                 375                 380                 


Arg Pro Trp Gln Arg Leu Val Arg Ile Val Gln Trp Gly Trp Leu Glu 
385                 390                 395                 400 


Leu Pro Trp Val Lys Gln Asn Ile Asn Arg Gln Gly Asn Ala Pro Val 
                405                 410                 415     


Ala Ser Gly Arg Tyr Cys Gln Pro Glu Glu Glu Val Ala Arg Leu Leu 
            420                 425                 430         


Thr Met Ala Gly Val Pro Glu Asp Glu Leu Asn Pro Phe His Val Leu 
        435                 440                 445             


Gly Val Glu Ala Thr Ala Ser Asp Val Glu Leu Lys Lys Ala Tyr Arg 
    450                 455                 460                 


Gln Leu Ala Val Met Val His Pro Asp Lys Asn His His Pro Arg Ala 
465                 470                 475                 480 


Glu Glu Ala Phe Lys Val Leu Arg Ala Ala Trp Asp Ile Val Ser Asn 
                485                 490                 495     


Ala Glu Lys Arg Lys Glu Tyr Glu Met Lys Arg Met Ala Glu Asn Glu 
            500                 505                 510         


Leu Ser Arg Ser Val Asn Glu Phe Leu Ser Lys Leu Gln Asp Asp Leu 
        515                 520                 525             


Lys Glu Ala Met Asn Thr Met Met Cys Ser Arg Cys Gln Gly Lys His 
    530                 535                 540                 


Arg Arg Phe Glu Met Asp Arg Glu Pro Lys Ser Ala Arg Tyr Cys Ala 
545                 550                 555                 560 


Glu Cys Asn Arg Leu His Pro Ala Glu Glu Gly Asp Phe Trp Ala Glu 
                565                 570                 575     


Ser Ser Met Leu Gly Leu Lys Ile Thr Tyr Phe Ala Leu Met Asp Gly 
            580                 585                 590         


Lys Val Tyr Asp Ile Thr Glu Trp Ala Gly Cys Gln Arg Val Gly Ile 
        595                 600                 605             


Ser Pro Asp Thr His Arg Val Pro Tyr His Ile Ser Phe Gly Ser Arg 
    610                 615                 620                 


Ile Pro Gly Thr Arg Gly Arg Gln Arg Ala Thr Pro Asp Ala Pro Pro 
625                 630                 635                 640 


Ala Asp Leu Gln Asp Phe Leu Ser Arg Ile Phe Gln Val Pro Pro Gly 
                645                 650                 655     


Gln Met Pro Asn Gly Asn Phe Phe Ala Ala Pro Gln Pro Ala Pro Gly 
            660                 665                 670         


Ala Ala Ala Ala Ser Lys Pro Asn Ser Thr Val Pro Lys Gly Glu Ala 
        675                 680                 685             


Lys Pro Lys Arg Arg Lys Lys Val Arg Arg Pro Phe Gln Arg 
    690                 695                 700         


<210>  3167
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC15__Homo_sapiens__NP_037370

<400>  3167

Met Ala Ala Arg Gly Val Ile Ala Pro Val Gly Glu Ser Leu Arg Tyr 
1               5                   10                  15      


Ala Glu Tyr Leu Gln Pro Ser Ala Lys Arg Pro Asp Ala Asp Val Asp 
            20                  25                  30          


Gln Gln Arg Leu Val Arg Ser Leu Ile Ala Val Gly Leu Gly Val Ala 
        35                  40                  45              


Ala Leu Ala Phe Ala Gly Arg Tyr Ala Phe Arg Ile Trp Lys Pro Leu 
    50                  55                  60                  


Glu Gln Val Ile Thr Glu Thr Ala Lys Lys Ile Ser Thr Pro Ser Phe 
65                  70                  75                  80  


Ser Ser Tyr Tyr Lys Gly Gly Phe Glu Gln Lys Met Ser Arg Arg Glu 
                85                  90                  95      


Ala Gly Leu Ile Leu Gly Val Ser Pro Ser Ala Gly Lys Ala Lys Ile 
            100                 105                 110         


Arg Thr Ala His Arg Arg Val Met Ile Leu Asn His Pro Asp Lys Gly 
        115                 120                 125             


Gly Ser Pro Tyr Val Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu 
    130                 135                 140                 


Glu Thr Thr Thr Lys His 
145                 150 


<210>  3168
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC18__Homo_sapiens__NP_689899

<400>  3168

Met Ala Ala Thr Leu Gly Ser Gly Glu Arg Trp Thr Glu Ala Tyr Ile 
1               5                   10                  15      


Asp Ala Val Arg Arg Asn Lys Tyr Pro Glu Asp Thr Pro Pro Glu Ser 
            20                  25                  30          


His Asp Pro Cys Gly Cys Cys Asn Cys Met Lys Ala Gln Lys Glu Lys 
        35                  40                  45              


Lys Ser Glu Asn Glu Trp Thr Gln Thr Arg Gln Gly Glu Gly Asn Ser 
    50                  55                  60                  


Thr Tyr Ser Glu Glu Gln Leu Leu Gly Val Gln Arg Ile Lys Lys Cys 
65                  70                  75                  80  


Arg Asn Tyr Tyr Glu Ile Leu Gly Val Ser Arg Asp Ala Ser Asp Glu 
                85                  90                  95      


Glu Leu Lys Lys Ala Tyr Arg Lys Leu Ala Leu Lys Phe His Pro Asp 
            100                 105                 110         


Lys Asn Cys Ala Pro Gly Ala Thr Asp Ala Phe Lys Ala Ile Gly Asn 
        115                 120                 125             


Ala Phe Ala Val Leu Ser Asn Pro Asp Lys Arg Leu Arg Tyr Asp Glu 
    130                 135                 140                 


Tyr Gly Asp Glu Gln Val Thr Phe Thr Ala Pro Arg Ala Arg Pro Tyr 
145                 150                 155                 160 


Asn Tyr Tyr Arg Asp Phe Glu Ala Asp Ile Thr Pro Glu Glu Leu Phe 
                165                 170                 175     


Asn Val Phe Phe Gly Gly His Phe Pro Thr Gly Asn Ile His Met Phe 
            180                 185                 190         


Ser Asn Val Thr Asp Asp Thr Tyr Tyr Tyr Arg Arg Arg His Arg His 
        195                 200                 205             


Glu Arg Thr Gln Thr Gln Lys Glu Glu Glu Glu Glu Lys Pro Gln Thr 
    210                 215                 220                 


Thr Tyr Ser Ala Phe Ile Gln Leu Leu Pro Val Leu Val Ile Val Ile 
225                 230                 235                 240 


Ile Ser Val Ile Thr Gln Leu Leu Ala Thr Asn Pro Pro Tyr Ser Leu 
                245                 250                 255     


Phe Tyr Lys Ser Thr Leu Gly Tyr Thr Ile Ser Arg Glu Thr Gln Asn 
            260                 265                 270         


Leu Gln Val Pro Tyr Phe Val Asp Lys Asn Phe Asp Lys Ala Tyr Arg 
        275                 280                 285             


Gly Ala Ser Leu His Asp Leu Glu Lys Thr Ile Glu Lys Asp Tyr Ile 
    290                 295                 300                 


Asp Tyr Ile Gln Thr Ser Cys Trp Lys Glu Lys Gln Gln Lys Ser Glu 
305                 310                 315                 320 


Leu Thr Asn Leu Ala Gly Leu Tyr Arg Asp Glu Arg Leu Lys Gln Lys 
                325                 330                 335     


Ala Glu Ser Leu Lys Leu Glu Asn Cys Glu Lys Leu Ser Lys Leu Ile 
            340                 345                 350         


Gly Leu Arg Arg Gly Gly 
        355             


<210>  3169
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC19__Homo_sapiens__NP_660304

<400>  3169

Met Ala Ser Thr Val Val Ala Val Gly Leu Thr Ile Ala Ala Ala Gly 
1               5                   10                  15      


Phe Ala Gly Arg Tyr Val Leu Gln Ala Met Lys His Met Glu Pro Gln 
            20                  25                  30          


Val Lys Gln Val Phe Gln Ser Leu Pro Lys Ser Ala Phe Ser Gly Gly 
        35                  40                  45              


Tyr Tyr Arg Gly Gly Phe Glu Pro Lys Met Thr Lys Arg Glu Ala Ala 
    50                  55                  60                  


Leu Ile Leu Gly Val Ser Pro Thr Ala Asn Lys Gly Lys Ile Arg Asp 
65                  70                  75                  80  


Ala His Arg Arg Ile Met Leu Leu Asn His Pro Asp Lys Gly Gly Ser 
                85                  90                  95      


Pro Tyr Ile Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu Glu Gly 
            100                 105                 110         


Gln Ala Lys Lys 
        115     


<210>  3170
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC1__Homo_sapiens__NP_071760

<400>  3170

Met Thr Ala Pro Cys Ser Gln Pro Ala Gln Leu Pro Gly Arg Arg Gln 
1               5                   10                  15      


Leu Gly Leu Val Pro Phe Pro Pro Pro Pro Pro Arg Thr Pro Leu Leu 
            20                  25                  30          


Trp Leu Leu Leu Leu Leu Leu Ala Ala Val Ala Pro Ala Arg Gly Trp 
        35                  40                  45              


Glu Ser Gly Asp Leu Glu Leu Phe Asp Leu Val Glu Glu Val Gln Leu 
    50                  55                  60                  


Asn Phe Tyr Gln Phe Leu Gly Val Gln Gln Asp Ala Ser Ser Ala Asp 
65                  70                  75                  80  


Ile Arg Lys Ala Tyr Arg Lys Leu Ser Leu Thr Leu His Pro Asp Lys 
                85                  90                  95      


Asn Lys Asp Glu Asn Ala Glu Thr Gln Phe Arg Gln Leu Val Ala Ile 
            100                 105                 110         


Tyr Glu Val Leu Lys Asp Asp Glu Arg Arg Gln Arg Tyr Asp Asp Ile 
        115                 120                 125             


Leu Ile Asn Gly Leu Pro Asp Trp Arg Gln Pro Val Phe Tyr Tyr Arg 
    130                 135                 140                 


Arg Val Arg Lys Met Ser Asn Ala Glu Leu Ala Leu Leu Leu Phe Ile 
145                 150                 155                 160 


Ile Leu Thr Val Gly His Tyr Ala Val Val Trp Ser Ile Tyr Leu Glu 
                165                 170                 175     


Lys Gln Leu Asp Glu Leu Leu Ser Arg Lys Lys Arg Glu Lys Lys Lys 
            180                 185                 190         


Lys Thr Gly Ser Lys Ser Val Asp Val Ser Lys Leu Gly Ala Ser Glu 
        195                 200                 205             


Lys Asn Glu Arg Leu Leu Met Lys Pro Gln Trp His Asp Leu Leu Pro 
    210                 215                 220                 


Cys Lys Leu Gly Ile Trp Phe Cys Leu Thr Leu Lys Ala Leu Pro His 
225                 230                 235                 240 


Leu Ile Gln Asp Ala Gly Gln Phe Tyr Ala Lys Tyr Lys Glu Thr Arg 
                245                 250                 255     


Leu Lys Glu Lys Glu Asp Ala Leu Thr Arg Thr Glu Leu Glu Thr Leu 
            260                 265                 270         


Gln Lys Gln Lys Lys Val Lys Lys Pro Lys Pro Glu Phe Pro Val Tyr 
        275                 280                 285             


Thr Pro Leu Glu Thr Thr Tyr Ile Gln Ser Tyr Asp His Gly Thr Ser 
    290                 295                 300                 


Ile Glu Glu Ile Glu Glu Gln Met Asp Asp Trp Leu Glu Asn Arg Asn 
305                 310                 315                 320 


Arg Thr Gln Lys Lys Gln Ala Pro Glu Trp Thr Glu Glu Asp Leu Ser 
                325                 330                 335     


Gln Leu Thr Arg Ser Met Val Lys Phe Pro Gly Gly Thr Pro Gly Arg 
            340                 345                 350         


Trp Glu Lys Ile Ala His Glu Leu Gly Arg Ser Val Thr Asp Val Thr 
        355                 360                 365             


Thr Lys Ala Lys Gln Leu Lys Asp Ser Val Thr Cys Ser Pro Gly Met 
    370                 375                 380                 


Val Arg Leu Ser Glu Leu Lys Ser Thr Val Gln Asn Ser Arg Pro Ile 
385                 390                 395                 400 


Lys Thr Ala Thr Thr Leu Pro Asp Asp Met Ile Thr Gln Arg Glu Asp 
                405                 410                 415     


Ala Glu Gly Val Ala Ala Glu Glu Glu Gln Glu Gly Asp Ser Gly Glu 
            420                 425                 430         


Gln Glu Thr Gly Ala Thr Asp Ala Arg Pro Arg Arg Arg Lys Pro Ala 
        435                 440                 445             


Arg Leu Leu Glu Ala Thr Ala Lys Pro Glu Pro Glu Glu Lys Ser Arg 
    450                 455                 460                 


Ala Lys Arg Gln Lys Asp Phe Asp Ile Ala Glu Gln Asn Glu Ser Ser 
465                 470                 475                 480 


Asp Glu Glu Ser Leu Arg Lys Glu Arg Ala Arg Ser Ala Glu Glu Pro 
                485                 490                 495     


Trp Thr Gln Asn Gln Gln Lys Leu Leu Glu Leu Ala Leu Gln Gln Tyr 
            500                 505                 510         


Pro Arg Gly Ser Ser Asp Arg Trp Asp Lys Ile Ala Arg Cys Val Pro 
        515                 520                 525             


Ser Lys Ser Lys Glu Asp Cys Ile Ala Arg Tyr Lys Leu Leu Val Glu 
    530                 535                 540                 


Leu Val Gln Lys Lys Lys Gln Ala Lys Ser 
545                 550                 


<210>  3171
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC27__Homo_sapiens__NP_057628

<400>  3171

Met Glu Ala Asn Met Pro Lys Arg Lys Glu Pro Gly Arg Ser Leu Arg 
1               5                   10                  15      


Ile Lys Val Ile Ser Met Gly Asn Ala Glu Val Gly Lys Ser Cys Ile 
            20                  25                  30          


Ile Lys Arg Tyr Cys Glu Lys Arg Phe Val Ser Lys Tyr Leu Ala Thr 
        35                  40                  45              


Ile Gly Ile Asp Tyr Gly Val Thr Lys Val His Val Arg Asp Arg Glu 
    50                  55                  60                  


Ile Lys Val Asn Ile Phe Asp Met Ala Gly His Pro Phe Phe Tyr Glu 
65                  70                  75                  80  


Val Arg Asn Glu Phe Tyr Lys Asp Thr Gln Gly Val Ile Leu Val Tyr 
                85                  90                  95      


Asp Val Gly Gln Lys Asp Ser Phe Asp Ala Leu Asp Ala Trp Leu Ala 
            100                 105                 110         


Glu Met Lys Gln Glu Leu Gly Pro His Gly Asn Met Glu Asn Ile Ile 
        115                 120                 125             


Phe Val Val Cys Ala Asn Lys Ile Asp Cys Thr Lys His Arg Cys Val 
    130                 135                 140                 


Asp Glu Ser Glu Gly Arg Leu Trp Ala Glu Ser Lys Gly Phe Leu Tyr 
145                 150                 155                 160 


Phe Glu Thr Ser Ala Gln Thr Gly Glu Gly Ile Asn Glu Met Phe Gln 
                165                 170                 175     


Thr Phe Tyr Ile Ser Ile Val Asp Leu Cys Glu Asn Gly Gly Lys Arg 
            180                 185                 190         


Pro Thr Thr Asn Ser Ser Ala Ser Phe Thr Lys Glu Gln Ala Asp Ala 
        195                 200                 205             


Ile Arg Arg Ile Arg Asn Ser Lys Asp Ser Trp Asp Met Leu Gly Val 
    210                 215                 220                 


Lys Pro Gly Ala Ser Arg Asp Glu Val Asn Lys Ala Tyr Arg Lys Leu 
225                 230                 235                 240 


Ala Val Leu Leu His Pro Asp Lys Cys Val Ala Pro Gly Ser Glu Asp 
                245                 250                 255     


Ala Phe Lys Ala Val Val Asn Ala Arg Thr Ala Leu Leu Lys Asn Ile 
            260                 265                 270         


Lys 
    


<210>  3172
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC28__Homo_sapiens__NP_060303

<400>  3172

Met Asn Thr Met Tyr Val Met Met Ala Gln Ile Leu Arg Ser His Leu 
1               5                   10                  15      


Ile Lys Ala Thr Val Ile Pro Asn Arg Val Lys Met Leu Pro Tyr Phe 
            20                  25                  30          


Gly Ile Ile Arg Asn Arg Met Met Ser Thr His Lys Ser Lys Lys Lys 
        35                  40                  45              


Ile Arg Glu Tyr Tyr Arg Leu Leu Asn Val Glu Glu Gly Cys Ser Ala 
    50                  55                  60                  


Asp Glu Val Arg Glu Ser Phe His Lys Leu Ala Lys Gln Tyr His Pro 
65                  70                  75                  80  


Asp Ser Gly Ser Asn Thr Ala Asp Ser Ala Thr Phe Ile Arg Ile Glu 
                85                  90                  95      


Lys Ala Tyr Arg Lys Val Leu Ser His Val Ile Glu Gln Thr Asn Ala 
            100                 105                 110         


Ser Gln Ser Lys Gly Glu Glu Glu Glu Asp Val Glu Lys Phe Lys Tyr 
        115                 120                 125             


Lys Thr Pro Gln His Arg His Tyr Leu Ser Phe Glu Gly Ile Gly Phe 
    130                 135                 140                 


Gly Thr Pro Thr Gln Arg Glu Lys His Tyr Arg Gln Phe Arg Ala Asp 
145                 150                 155                 160 


Arg Ala Ala Glu Gln Val Met Glu Tyr Gln Lys Gln Lys Leu Gln Ser 
                165                 170                 175     


Gln Tyr Phe Pro Asp Ser Val Ile Val Lys Asn Ile Arg Gln Ser Lys 
            180                 185                 190         


Gln Gln Lys Ile Thr Gln Ala Ile Glu Arg Leu Val Glu Asp Leu Ile 
        195                 200                 205             


Gln Glu Ser Met Ala Lys Gly Asp Phe Asp Asn Leu Ser Gly Lys Gly 
    210                 215                 220                 


Lys Pro Leu Lys Lys Phe Ser Asp Cys Ser Tyr Ile Asp Pro Met Thr 
225                 230                 235                 240 


His Asn Leu Asn Arg Ile Leu Ile Asp Asn Gly Tyr Gln Pro Glu Trp 
                245                 250                 255     


Ile Leu Lys Gln Lys Glu Ile Ser Asp Thr Ile Glu Gln Leu Arg Glu 
            260                 265                 270         


Ala Ile Leu Val Ser Arg Lys Lys Leu Gly Asn Pro Met Thr Pro Thr 
        275                 280                 285             


Glu Lys Lys Gln Trp Asn His Val Cys Glu Gln Phe Gln Glu Asn Ile 
    290                 295                 300                 


Arg Lys Leu Asn Lys Arg Ile Asn Asp Phe Asn Leu Ile Val Pro Ile 
305                 310                 315                 320 


Leu Thr Arg Gln Lys Val His Phe Asp Ala Gln Lys Glu Ile Val Arg 
                325                 330                 335     


Ala Gln Lys Ile Tyr Glu Thr Leu Ile Lys Thr Lys Glu Val Thr Asp 
            340                 345                 350         


Arg Asn Pro Asn Asn Leu Asp Gln Gly Glu Gly Glu Lys Thr Pro Glu 
        355                 360                 365             


Ile Lys Lys Gly Phe Leu Asn Trp Met Asn Leu Trp Lys Phe Ile Lys 
    370                 375                 380                 


Ile Arg Ser Phe 
385             


<210>  3173
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC2__Homo_sapiens__NP_001123359

<400>  3173

Met Leu Leu Leu Pro Ser Ala Ala Asp Gly Arg Gly Thr Ala Ile Thr 
1               5                   10                  15      


His Ala Leu Thr Ser Ala Ser Thr Leu Cys Gln Val Glu Pro Val Gly 
            20                  25                  30          


Arg Trp Phe Glu Ala Phe Val Lys Arg Arg Asn Arg Asn Ala Ser Ala 
        35                  40                  45              


Ser Phe Gln Glu Leu Glu Asp Lys Lys Glu Leu Ser Glu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Glu Leu Gln Leu Glu Glu Phe Pro Met Leu Lys Thr Leu Asp 
65                  70                  75                  80  


Pro Lys Asp Trp Lys Asn Gln Asp His Tyr Ala Val Leu Gly Leu Gly 
                85                  90                  95      


His Val Arg Tyr Lys Ala Thr Gln Arg Gln Ile Lys Ala Ala His Lys 
            100                 105                 110         


Ala Met Val Leu Lys His His Pro Asp Lys Arg Lys Ala Ala Gly Glu 
        115                 120                 125             


Pro Ile Lys Glu Gly Asp Asn Asp Tyr Phe Thr Cys Ile Thr Lys Ala 
    130                 135                 140                 


Tyr Glu Met Leu Ser Asp Pro Val Lys Arg Arg Ala Phe Asn Ser Val 
145                 150                 155                 160 


Asp Pro Thr Phe Asp Asn Ser Val Pro Ser Lys Ser Glu Ala Lys Asp 
                165                 170                 175     


Asn Phe Phe Glu Val Phe Thr Pro Val Phe Glu Arg Asn Ser Arg Trp 
            180                 185                 190         


Ser Asn Lys Lys Asn Val Pro Lys Leu Gly Asp Met Asn Ser Ser Phe 
        195                 200                 205             


Glu Asp Val Asp Ile Phe Tyr Ser Phe Trp Tyr Asn Phe Asp Ser Trp 
    210                 215                 220                 


Arg Glu Phe Ser Tyr Leu Asp Glu Glu Glu Lys Glu Lys Ala Glu Cys 
225                 230                 235                 240 


Arg Asp Glu Arg Arg Trp Ile Glu Lys Gln Asn Arg Ala Thr Arg Ala 
                245                 250                 255     


Gln Arg Lys Lys Glu Glu Met Asn Arg Ile Arg Thr Leu Val Asp Asn 
            260                 265                 270         


Ala Tyr Ser Cys Asp Pro Arg Ile Lys Lys Phe Lys Glu Glu Glu Lys 
        275                 280                 285             


Ala Lys Lys Glu Ala Glu Lys Lys Ala Lys Ala Glu Ala Lys Arg Lys 
    290                 295                 300                 


Glu Gln Glu Ala Lys Glu Lys Gln Arg Gln Ala Glu Leu Glu Ala Ala 
305                 310                 315                 320 


Arg Leu Ala Lys Glu Lys Glu Glu Glu Glu Val Arg Gln Gln Ala Leu 
                325                 330                 335     


Leu Ala Lys Lys Glu Lys Asp Ile Gln Lys Lys Ala Ile Lys Lys Glu 
            340                 345                 350         


Arg Gln Lys Leu Arg Asn Ser Cys Lys Ile Glu Glu Ile Asn Glu Gln 
        355                 360                 365             


Ile Arg Lys Glu Lys Glu Glu Ala Glu Ala Arg Met Arg Gln Ala Ser 
    370                 375                 380                 


Lys Asn Thr Glu Lys Ser Thr Gly Gly Gly Gly Asn Gly Ser Lys Asn 
385                 390                 395                 400 


Trp Ser Glu Asp Asp Leu Gln Leu Leu Ile Lys Ala Val Asn Leu Phe 
                405                 410                 415     


Pro Ala Gly Thr Asn Ser Arg Trp Glu Val Ile Ala Asn Tyr Met Asn 
            420                 425                 430         


Ile His Ser Ser Ser Gly Val Lys Arg Thr Ala Lys Asp Val Ile Gly 
        435                 440                 445             


Lys Ala Lys Ser Leu Gln Lys Leu Asp Pro His Gln Lys Asp Asp Ile 
    450                 455                 460                 


Asn Lys Lys Ala Phe Asp Lys Phe Lys Lys Glu His Gly Val Val Pro 
465                 470                 475                 480 


Gln Ala Asp Asn Ala Thr Pro Ser Glu Arg Phe Glu Gly Pro Tyr Thr 
                485                 490                 495     


Asp Phe Thr Pro Trp Thr Thr Glu Glu Gln Lys Leu Leu Glu Gln Ala 
            500                 505                 510         


Leu Lys Thr Tyr Pro Val Asn Thr Pro Glu Arg Trp Glu Lys Ile Ala 
        515                 520                 525             


Glu Ala Val Pro Gly Arg Thr Lys Lys Asp Cys Met Lys Arg Tyr Lys 
    530                 535                 540                 


Glu Leu Val Glu Met Val Lys Ala Lys Lys Ala Ala Gln Glu Gln Val 
545                 550                 555                 560 


Leu Asn Ala Ser Arg Ala Lys Lys 
                565             


<210>  3174
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC3__Homo_sapiens__NP_006251

<400>  3174

Met Val Ala Pro Gly Ser Val Thr Ser Arg Leu Gly Ser Val Phe Pro 
1               5                   10                  15      


Phe Leu Leu Val Leu Val Asp Leu Gln Tyr Glu Gly Ala Glu Cys Gly 
            20                  25                  30          


Val Asn Ala Asp Val Glu Lys His Leu Glu Leu Gly Lys Lys Leu Leu 
        35                  40                  45              


Ala Ala Gly Gln Leu Ala Asp Ala Leu Ser Gln Phe His Ala Ala Val 
    50                  55                  60                  


Asp Gly Asp Pro Asp Asn Tyr Ile Ala Tyr Tyr Arg Arg Ala Thr Val 
65                  70                  75                  80  


Phe Leu Ala Met Gly Lys Ser Lys Ala Ala Leu Pro Asp Leu Thr Lys 
                85                  90                  95      


Val Ile Gln Leu Lys Met Asp Phe Thr Ala Ala Arg Leu Gln Arg Gly 
            100                 105                 110         


His Leu Leu Leu Lys Gln Gly Lys Leu Asp Glu Ala Glu Asp Asp Phe 
        115                 120                 125             


Lys Lys Val Leu Lys Ser Asn Pro Ser Glu Asn Glu Glu Lys Glu Ala 
    130                 135                 140                 


Gln Ser Gln Leu Ile Lys Ser Asp Glu Met Gln Arg Leu Arg Ser Gln 
145                 150                 155                 160 


Ala Leu Asn Ala Phe Gly Ser Gly Asp Tyr Thr Ala Ala Ile Ala Phe 
                165                 170                 175     


Leu Asp Lys Ile Leu Glu Val Cys Val Trp Asp Ala Glu Leu Arg Glu 
            180                 185                 190         


Leu Arg Ala Glu Cys Phe Ile Lys Glu Gly Glu Pro Arg Lys Ala Ile 
        195                 200                 205             


Ser Asp Leu Lys Ala Ala Ser Lys Leu Lys Asn Asp Asn Thr Glu Ala 
    210                 215                 220                 


Phe Tyr Lys Ile Ser Thr Leu Tyr Tyr Gln Leu Gly Asp His Glu Leu 
225                 230                 235                 240 


Ser Leu Ser Glu Val Arg Glu Cys Leu Lys Leu Asp Gln Asp His Lys 
                245                 250                 255     


Arg Cys Phe Ala His Tyr Lys Gln Val Lys Lys Leu Asn Lys Leu Ile 
            260                 265                 270         


Glu Ser Ala Glu Glu Leu Ile Arg Asp Gly Arg Tyr Thr Asp Ala Thr 
        275                 280                 285             


Ser Lys Tyr Glu Ser Val Met Lys Thr Glu Pro Ser Ile Ala Glu Tyr 
    290                 295                 300                 


Thr Val Arg Ser Lys Glu Arg Ile Cys His Cys Phe Ser Lys Asp Glu 
305                 310                 315                 320 


Lys Pro Val Glu Ala Ile Arg Val Cys Ser Glu Val Leu Gln Met Glu 
                325                 330                 335     


Pro Asp Asn Val Asn Ala Leu Lys Asp Arg Ala Glu Ala Tyr Leu Ile 
            340                 345                 350         


Glu Glu Met Tyr Asp Glu Ala Ile Gln Asp Tyr Glu Thr Ala Gln Glu 
        355                 360                 365             


His Asn Glu Asn Asp Gln Gln Ile Arg Glu Gly Leu Glu Lys Ala Gln 
    370                 375                 380                 


Arg Leu Leu Lys Gln Ser Gln Lys Arg Asp Tyr Tyr Lys Ile Leu Gly 
385                 390                 395                 400 


Val Lys Arg Asn Ala Lys Lys Gln Glu Ile Ile Lys Ala Tyr Arg Lys 
                405                 410                 415     


Leu Ala Leu Gln Trp His Pro Asp Asn Phe Gln Asn Glu Glu Glu Lys 
            420                 425                 430         


Lys Lys Ala Glu Lys Lys Phe Ile Asp Ile Ala Ala Ala Lys Glu Val 
        435                 440                 445             


Leu Ser Asp Pro Glu Met Arg Lys Lys Phe Asp Asp Gly Glu Asp Pro 
    450                 455                 460                 


Leu Asp Ala Glu Ser Gln Gln Gly Gly Gly Gly Asn Pro Phe His Arg 
465                 470                 475                 480 


Ser Trp Asn Ser Trp Gln Gly Phe Asn Pro Phe Ser Ser Gly Gly Pro 
                485                 490                 495     


Phe Arg Phe Lys Phe His Phe Asn 
            500                 


<210>  3175
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC5__Homo_sapiens__NP_079495

<400>  3175

Met Ala Asp Gln Arg Gln Arg Ser Leu Ser Thr Ser Gly Glu Ser Leu 
1               5                   10                  15      


Tyr His Val Leu Gly Leu Asp Lys Asn Ala Thr Ser Asp Asp Ile Lys 
            20                  25                  30          


Lys Ser Tyr Arg Lys Leu Ala Leu Lys Tyr His Pro Asp Lys Asn Pro 
        35                  40                  45              


Asp Asn Pro Glu Ala Ala Asp Lys Phe Lys Glu Ile Asn Asn Ala His 
    50                  55                  60                  


Ala Ile Leu Thr Asp Ala Thr Lys Arg Asn Ile Tyr Asp Lys Tyr Gly 
65                  70                  75                  80  


Ser Leu Gly Leu Tyr Val Ala Glu Gln Phe Gly Glu Glu Asn Val Asn 
                85                  90                  95      


Thr Tyr Phe Val Leu Ser Ser Trp Trp Ala Lys Ala Leu Phe Val Phe 
            100                 105                 110         


Cys Gly Leu Leu Thr Cys Cys Tyr Cys Cys Cys Cys Leu Cys Cys Cys 
        115                 120                 125             


Phe Asn Cys Cys Cys Gly Lys Cys Lys Pro Lys Ala Pro Glu Gly Glu 
    130                 135                 140                 


Glu Thr Glu Phe Tyr Val Ser Pro Glu Asp Leu Glu Ala Gln Leu Gln 
145                 150                 155                 160 


Ser Asp Glu Arg Glu Ala Thr Asp Thr Pro Ile Val Ile Gln Pro Ala 
                165                 170                 175     


Ser Ala Thr Glu Thr Thr Gln Leu Thr Ala Asp Ser His Pro Ser Tyr 
            180                 185                 190         


His Thr Asp Gly Phe Asn 
        195             


<210>  3176
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAJC7__Homo_sapiens__NP_001138238

<400>  3176

Met Cys Pro Lys Asn Ala Ser Tyr Tyr Gly Asn Arg Ala Ala Thr Leu 
1               5                   10                  15      


Met Met Leu Gly Arg Phe Arg Glu Ala Leu Gly Asp Ala Gln Gln Ser 
            20                  25                  30          


Val Arg Leu Asp Asp Ser Phe Val Arg Gly His Leu Arg Glu Gly Lys 
        35                  40                  45              


Cys His Leu Ser Leu Gly Asn Ala Met Ala Ala Cys Arg Ser Phe Gln 
    50                  55                  60                  


Arg Ala Leu Glu Leu Asp His Lys Asn Ala Gln Ala Gln Gln Glu Phe 
65                  70                  75                  80  


Lys Asn Ala Asn Ala Val Met Glu Tyr Glu Lys Ile Ala Glu Thr Asp 
                85                  90                  95      


Phe Glu Lys Arg Asp Phe Arg Lys Val Val Phe Cys Met Asp Arg Ala 
            100                 105                 110         


Leu Glu Phe Ala Pro Ala Cys His Arg Phe Lys Ile Leu Lys Ala Glu 
        115                 120                 125             


Cys Leu Ala Met Leu Gly Arg Tyr Pro Glu Ala Gln Ser Val Ala Ser 
    130                 135                 140                 


Asp Ile Leu Arg Met Asp Ser Thr Asn Ala Asp Ala Leu Tyr Val Arg 
145                 150                 155                 160 


Gly Leu Cys Leu Tyr Tyr Glu Asp Cys Ile Glu Lys Ala Val Gln Phe 
                165                 170                 175     


Phe Val Gln Ala Leu Arg Met Ala Pro Asp His Glu Lys Ala Cys Ile 
            180                 185                 190         


Ala Cys Arg Asn Ala Lys Ala Leu Lys Ala Lys Lys Glu Asp Gly Asn 
        195                 200                 205             


Lys Ala Phe Lys Glu Gly Asn Tyr Lys Leu Ala Tyr Glu Leu Tyr Thr 
    210                 215                 220                 


Glu Ala Leu Gly Ile Asp Pro Asn Asn Ile Lys Thr Asn Ala Lys Leu 
225                 230                 235                 240 


Tyr Cys Asn Arg Gly Thr Val Asn Ser Lys Leu Arg Lys Leu Asp Asp 
                245                 250                 255     


Ala Ile Glu Asp Cys Thr Asn Ala Val Lys Leu Asp Asp Thr Tyr Ile 
            260                 265                 270         


Lys Ala Tyr Leu Arg Arg Ala Gln Cys Tyr Met Asp Thr Glu Gln Tyr 
        275                 280                 285             


Glu Glu Ala Val Arg Asp Tyr Glu Lys Val Tyr Gln Thr Glu Lys Thr 
    290                 295                 300                 


Lys Glu His Lys Gln Leu Leu Lys Asn Ala Gln Leu Glu Leu Lys Lys 
305                 310                 315                 320 


Ser Lys Arg Lys Asp Tyr Tyr Lys Ile Leu Gly Val Asp Lys Asn Ala 
                325                 330                 335     


Ser Glu Asp Glu Ile Lys Lys Ala Tyr Arg Lys Arg Ala Leu Met His 
            340                 345                 350         


His Pro Asp Arg His Ser Gly Ala Ser Ala Glu Val Gln Lys Glu Glu 
        355                 360                 365             


Glu Lys Lys Phe Lys Glu Val Gly Glu Ala Phe Thr Ile Leu Ser Asp 
    370                 375                 380                 


Pro Lys Lys Lys Thr Arg Tyr Asp Ser Gly Gln Asp Leu Asp Glu Glu 
385                 390                 395                 400 


Gly Met Asn Met Gly Asp Phe Asp Pro Asn Asn Ile Phe Lys Ala Phe 
                405                 410                 415     


Phe Gly Gly Pro Gly Gly Phe Ser Phe Glu Ala Ser Gly Pro Gly Asn 
            420                 425                 430         


Phe Phe Phe Gln Phe Gly 
        435             


<210>  3177
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNAL1__Homo_sapiens__NP_113615

<400>  3177

Met Ala Lys Ala Thr Thr Ile Lys Glu Ala Leu Ala Arg Trp Glu Glu 
1               5                   10                  15      


Lys Thr Gly Gln Arg Pro Ser Glu Ala Lys Glu Ile Lys Leu Tyr Ala 
            20                  25                  30          


Gln Ile Pro Pro Ile Glu Lys Met Asp Ala Ser Leu Ser Met Leu Ala 
        35                  40                  45              


Asn Cys Glu Lys Leu Ser Leu Ser Thr Asn Cys Ile Glu Lys Ile Ala 
    50                  55                  60                  


Asn Leu Asn Gly Leu Lys Asn Leu Arg Ile Leu Ser Leu Gly Arg Asn 
65                  70                  75                  80  


Asn Ile Lys Asn Leu Asn Gly Leu Glu Ala Val Gly Asp Thr Leu Glu 
                85                  90                  95      


Glu Leu Trp Ile Ser Tyr Asn Phe Ile Glu Lys Leu Lys Gly Ile His 
            100                 105                 110         


Ile Met Lys Lys Leu Lys Ile Leu Tyr Met Ser Asn Asn Leu Val Lys 
        115                 120                 125             


Asp Trp Ala Glu Phe Val Lys Leu Ala Glu Leu Pro Cys Leu Glu Asp 
    130                 135                 140                 


Leu Val Phe Val Gly Asn Pro Leu Glu Glu Lys His Ser Ala Glu Asn 
145                 150                 155                 160 


Asn Trp Ile Glu Glu Ala Thr Lys Arg Val Pro Lys Leu Lys Lys Leu 
                165                 170                 175     


Asp Gly Thr Pro Val Ile Lys Gly Asp Glu Glu Glu Asp Asn 
            180                 185                 190 


<210>  3178
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNASE1__Homo_sapiens__XP_011520696

<400>  3178

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys 
        275                 280         


<210>  3179
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNASE1L2__Homo_sapiens__NP_001288609

<400>  3179

Met Gly Gly Pro Arg Ala Leu Leu Ala Ala Leu Trp Ala Leu Glu Ala 
1               5                   10                  15      


Ala Gly Thr Ala Ala Leu Arg Ile Gly Ala Phe Asn Ile Gln Ser Phe 
            20                  25                  30          


Gly Asp Ser Lys Val Ser Asp Pro Ala Cys Gly Ser Ile Ile Ala Lys 
        35                  40                  45              


Ile Leu Ala Gly Tyr Asp Leu Ala Leu Val Gln Glu Val Arg Asp Pro 
    50                  55                  60                  


Asp Leu Ser Ala Val Ser Ala Leu Met Glu Gln Ile Asn Ser Val Ser 
65                  70                  75                  80  


Glu His Glu Tyr Ser Phe Val Ser Ser Gln Pro Leu Gly Arg Asp Gln 
                85                  90                  95      


Tyr Lys Glu Met Tyr Leu Phe Val Tyr Arg Lys Asp Ala Val Ser Val 
            100                 105                 110         


Val Asp Thr Tyr Leu Tyr Pro Asp Pro Glu Asp Val Phe Ser Arg Glu 
        115                 120                 125             


Pro Phe Val Val Lys Phe Ser Ala Pro Gly Thr Gly Glu Arg Ala Pro 
    130                 135                 140                 


Pro Leu Pro Ser Arg Arg Ala Leu Thr Pro Pro Pro Leu Pro Ala Ala 
145                 150                 155                 160 


Ala Gln Asn Leu Val Leu Ile Pro Leu His Ala Ala Pro His Gln Ala 
                165                 170                 175     


Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val Ile Asp 
            180                 185                 190         


Lys Trp Gly Thr Asp Asp Met Leu Phe Leu Gly Asp Phe Asn Ala Asp 
        195                 200                 205             


Cys Ser Tyr Val Arg Ala Gln Asp Trp Ala Ala Ile Arg Leu Arg Ser 
    210                 215                 220                 


Ser Glu Val Phe Lys Trp Leu Ile Pro Asp Ser Ala Asp Thr Thr Val 
225                 230                 235                 240 


Gly Asn Ser Asp Cys Ala Tyr Asp Arg Ile Val Ala Cys Gly Ala Arg 
                245                 250                 255     


Leu Arg Arg Ser Leu Lys Pro Gln Ser Ala Thr Val His Asp Phe Gln 
            260                 265                 270         


Glu Glu Phe Gly Leu Asp Gln Thr Gln Ala Leu Ala Ile Ser Asp His 
        275                 280                 285             


Phe Pro Val Glu Val Thr Leu Lys Phe His Arg 
    290                 295                 


<210>  3180
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNASE1L3__Homo_sapiens__NP_001243489

<400>  3180

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Glu Lys Leu 
65                  70                  75                  80  


Val Ser Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp 
                85                  90                  95      


Ala Asp Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro 
            100                 105                 110         


His Thr Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro 
        115                 120                 125             


Glu Thr Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp 
    130                 135                 140                 


Val Lys His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe 
145                 150                 155                 160 


Asn Ala Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg 
                165                 170                 175     


Leu Arg Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp 
            180                 185                 190         


Thr Thr Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu 
        195                 200                 205             


Arg Gly Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val 
    210                 215                 220                 


Phe Asp Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp 
225                 230                 235                 240 


Val Ser Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala 
                245                 250                 255     


Phe Thr Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser 
            260                 265                 270         


Lys Arg Ser 
        275 


<210>  3181
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNASE2B__Homo_sapiens__XP_011540180

<400>  3181

Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
1               5                   10                  15      


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
            20                  25                  30          


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
        35                  40                  45              


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
    50                  55                  60                  


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
65                  70                  75                  80  


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
                85                  90                  95      


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
            100                 105                 110         


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
        115                 120                 125             


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
    130                 135                 140                 


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
145                 150             


<210>  3182
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNASE2__Homo_sapiens__NP_001366

<400>  3182

Met Ile Pro Leu Leu Leu Ala Ala Leu Leu Cys Val Pro Ala Gly Ala 
1               5                   10                  15      


Leu Thr Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val 
            20                  25                  30          


Tyr Lys Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly 
        35                  40                  45              


Leu Gln Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly 
    50                  55                  60                  


Arg Ala Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln 
65                  70                  75                  80  


Pro Leu Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn 
                85                  90                  95      


Asp Gln Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly 
            100                 105                 110         


His Thr Lys Gly Val Leu Leu Leu Asp His Asp Gly Gly Phe Trp Leu 
        115                 120                 125             


Val His Ser Val Pro Asn Phe Pro Pro Pro Ala Ser Ser Ala Ala Tyr 
    130                 135                 140                 


Ser Trp Pro His Ser Ala Cys Thr Tyr Gly Gln Thr Leu Leu Cys Val 
145                 150                 155                 160 


Ser Phe Pro Phe Ala Gln Phe Ser Lys Met Gly Lys Gln Leu Thr Tyr 
                165                 170                 175     


Thr Tyr Pro Trp Val Tyr Asn Tyr Gln Leu Glu Gly Ile Phe Ala Gln 
            180                 185                 190         


Glu Phe Pro Asp Leu Glu Asn Val Val Lys Gly His His Val Ser Gln 
        195                 200                 205             


Glu Pro Trp Asn Ser Ser Ile Thr Leu Thr Ser Gln Ala Gly Ala Val 
    210                 215                 220                 


Phe Gln Ser Phe Ala Lys Phe Ser Lys Phe Gly Asp Asp Leu Tyr Ser 
225                 230                 235                 240 


Gly Trp Leu Ala Ala Ala Leu Gly Thr Asn Leu Gln Val Gln Phe Trp 
                245                 250                 255     


His Lys Thr Val Gly Ile Leu Pro Ser Asn Cys Ser Asp Ile Trp Gln 
            260                 265                 270         


Val Leu Asn Val Asn Gln Ile Ala Phe Pro Gly Pro Ala Gly Pro Ser 
        275                 280                 285             


Phe Asn Ser Thr Glu Asp His Ser Lys Trp Cys Val Ser Pro Lys Gly 
    290                 295                 300                 


Pro Trp Thr Cys Val Gly Asp Met Asn Arg Asn Gln Gly Glu Glu Gln 
305                 310                 315                 320 


Arg Gly Gly Gly Thr Leu Cys Ala Gln Leu Pro Ala Leu Trp Lys Ala 
                325                 330                 335     


Phe Gln Pro Leu Val Lys Asn Tyr Gln Pro Cys Asn Gly Met Ala Arg 
            340                 345                 350         


Lys Pro Ser Arg Ala Tyr Lys Ile 
        355                 360 


<210>  3183
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DND1__Homo_sapiens__NP_919225

<400>  3183

Met Gln Ser Lys Arg Asp Cys Glu Leu Trp Cys Glu Arg Val Asn Pro 
1               5                   10                  15      


Glu Asn Lys Ala Ala Leu Glu Ala Trp Val Arg Glu Thr Gly Ile Arg 
            20                  25                  30          


Leu Val Gln Val Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly 
        35                  40                  45              


Trp Val Gly Ser Pro Pro Pro Ala Gly Ser Glu Val Phe Ile Gly Arg 
    50                  55                  60                  


Leu Pro Gln Asp Val Tyr Glu His Gln Leu Ile Pro Leu Phe Gln Arg 
65                  70                  75                  80  


Val Gly Arg Leu Tyr Glu Phe Arg Leu Met Met Thr Phe Ser Gly Leu 
                85                  90                  95      


Asn Arg Gly Phe Ala Tyr Ala Arg Tyr Ser Ser Arg Arg Gly Ala Gln 
            100                 105                 110         


Ala Ala Ile Ala Thr Leu His Asn His Pro Leu Arg Pro Ser Cys Pro 
        115                 120                 125             


Leu Leu Val Cys Arg Ser Thr Glu Lys Cys Glu Leu Ser Val Asp Gly 
    130                 135                 140                 


Leu Pro Pro Asn Leu Thr Arg Ser Ala Leu Leu Leu Ala Leu Gln Pro 
145                 150                 155                 160 


Leu Gly Pro Gly Leu Gln Glu Ala Arg Leu Leu Pro Ser Pro Gly Pro 
                165                 170                 175     


Ala Pro Gly Gln Ile Ala Leu Leu Lys Phe Ser Ser His Arg Ala Ala 
            180                 185                 190         


Ala Met Ala Lys Lys Ala Leu Val Glu Gly Gln Ser His Leu Cys Gly 
        195                 200                 205             


Glu Gln Val Ala Val Glu Trp Leu Lys Pro Asp Leu Lys Gln Arg Leu 
    210                 215                 220                 


Arg Gln Gln Leu Val Gly Pro Phe Leu Arg Ser Pro Gln Pro Glu Gly 
225                 230                 235                 240 


Ser Gln Leu Ala Leu Ala Arg Asp Lys Leu Gly Phe Gln Gly Ala Arg 
                245                 250                 255     


Ala Thr Leu Gln Leu Leu Cys Gln Arg Met Lys Leu Gly Ser Pro Val 
            260                 265                 270         


Phe Leu Thr Lys Cys Leu Gly Ile Gly Pro Ala Gly Trp His Arg Phe 
        275                 280                 285             


Trp Tyr Gln Val Val Ile Pro Gly His Pro Val Pro Phe Ser Gly Leu 
    290                 295                 300                 


Ile Trp Val Val Leu Thr Leu Asp Gly Arg Asp Gly His Glu Val Ala 
305                 310                 315                 320 


Lys Asp Ala Val Ser Val Arg Leu Leu Gln Ala Leu Ser Glu Ser Gly 
                325                 330                 335     


Ala Asn Leu Leu Trp Ser Ala Gly Ala Glu Ala Gly Thr Met Val Lys 
            340                 345                 350         


Gln 
    


<210>  3184
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNER__Homo_sapiens__NP_620711

<400>  3184

Met Gln Pro Arg Arg Ala Gln Ala Pro Gly Ala Gln Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Leu Leu Leu Leu Leu Leu Gly Ala Gly Pro Arg Gly Ser Ser 
            20                  25                  30          


Leu Ala Asn Pro Val Pro Ala Ala Pro Leu Ser Ala Pro Gly Pro Cys 
        35                  40                  45              


Ala Ala Gln Pro Cys Arg Asn Gly Gly Val Cys Thr Ser Arg Pro Glu 
    50                  55                  60                  


Pro Asp Pro Gln His Pro Ala Pro Ala Gly Glu Pro Gly Tyr Ser Cys 
65                  70                  75                  80  


Thr Cys Pro Ala Gly Ile Ser Gly Ala Asn Cys Gln Leu Val Ala Asp 
                85                  90                  95      


Pro Cys Ala Ser Asn Pro Cys His His Gly Asn Cys Ser Ser Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Asp Gly Tyr Leu Cys Ile Cys Asn Glu Gly Tyr Glu 
        115                 120                 125             


Gly Pro Asn Cys Glu Gln Ala Leu Pro Ser Leu Pro Ala Thr Gly Trp 
    130                 135                 140                 


Thr Glu Ser Met Ala Pro Arg Gln Leu Gln Pro Val Pro Ala Thr Gln 
145                 150                 155                 160 


Glu Pro Asp Lys Ile Leu Pro Arg Ser Gln Ala Thr Val Thr Leu Pro 
                165                 170                 175     


Thr Trp Gln Pro Lys Thr Gly Gln Lys Val Val Glu Met Lys Trp Asp 
            180                 185                 190         


Gln Val Glu Val Ile Pro Asp Ile Ala Cys Gly Asn Ala Ser Ser Asn 
        195                 200                 205             


Ser Ser Ala Gly Gly Arg Leu Val Ser Phe Glu Val Pro Gln Asn Thr 
    210                 215                 220                 


Ser Val Lys Ile Arg Gln Asp Ala Thr Ala Ser Leu Ile Leu Leu Trp 
225                 230                 235                 240 


Lys Val Thr Ala Thr Gly Phe Gln Gln Cys Ser Leu Ile Asp Gly Arg 
                245                 250                 255     


Ser Val Thr Pro Leu Gln Ala Ser Gly Gly Leu Val Leu Leu Glu Glu 
            260                 265                 270         


Met Leu Ala Leu Gly Asn Asn His Phe Ile Gly Phe Val Asn Asp Ser 
        275                 280                 285             


Val Thr Lys Ser Ile Val Ala Leu Arg Leu Thr Leu Val Val Lys Val 
    290                 295                 300                 


Ser Thr Cys Val Pro Gly Glu Ser His Ala Asn Asp Leu Glu Cys Ser 
305                 310                 315                 320 


Gly Lys Gly Lys Cys Thr Thr Lys Pro Ser Glu Ala Thr Phe Ser Cys 
                325                 330                 335     


Thr Cys Glu Glu Gln Tyr Val Gly Thr Phe Cys Glu Glu Tyr Asp Ala 
            340                 345                 350         


Cys Gln Arg Lys Pro Cys Gln Asn Asn Ala Ser Cys Ile Asp Ala Asn 
        355                 360                 365             


Glu Lys Gln Asp Gly Ser Asn Phe Thr Cys Val Cys Leu Pro Gly Tyr 
    370                 375                 380                 


Thr Gly Glu Leu Cys Gln Ser Lys Ile Asp Tyr Cys Ile Leu Asp Pro 
385                 390                 395                 400 


Cys Arg Asn Gly Ala Thr Cys Ile Ser Ser Leu Ser Gly Phe Thr Cys 
                405                 410                 415     


Gln Cys Pro Glu Gly Tyr Phe Gly Ser Ala Cys Glu Glu Lys Val Asp 
            420                 425                 430         


Pro Cys Ala Ser Ser Pro Cys Gln Asn Asn Gly Thr Cys Tyr Val Asp 
        435                 440                 445             


Gly Val His Phe Thr Cys Asn Cys Ser Pro Gly Phe Thr Gly Pro Thr 
    450                 455                 460                 


Cys Ala Gln Leu Ile Asp Phe Cys Ala Leu Ser Pro Cys Ala His Gly 
465                 470                 475                 480 


Thr Cys Arg Ser Val Gly Thr Ser Tyr Lys Cys Leu Cys Asp Pro Gly 
                485                 490                 495     


Tyr His Gly Leu Tyr Cys Glu Glu Glu Tyr Asn Glu Cys Leu Ser Ala 
            500                 505                 510         


Pro Cys Leu Asn Ala Ala Thr Cys Arg Asp Leu Val Asn Gly Tyr Glu 
        515                 520                 525             


Cys Val Cys Leu Ala Glu Tyr Lys Gly Thr His Cys Glu Leu Tyr Lys 
    530                 535                 540                 


Asp Pro Cys Ala Asn Val Ser Cys Leu Asn Gly Ala Thr Cys Asp Ser 
545                 550                 555                 560 


Asp Gly Leu Asn Gly Thr Cys Ile Cys Ala Pro Gly Phe Thr Gly Glu 
                565                 570                 575     


Glu Cys Asp Ile Asp Ile Asn Glu Cys Asp Ser Asn Pro Cys His His 
            580                 585                 590         


Gly Gly Ser Cys Leu Asp Gln Pro Asn Gly Tyr Asn Cys His Cys Pro 
        595                 600                 605             


His Gly Trp Val Gly Ala Asn Cys Glu Ile His Leu Gln Trp Lys Ser 
    610                 615                 620                 


Gly His Met Ala Glu Ser Leu Thr Asn Met Pro Arg His Ser Leu Tyr 
625                 630                 635                 640 


Ile Ile Ile Gly Ala Leu Cys Val Ala Phe Ile Leu Met Leu Ile Ile 
                645                 650                 655     


Leu Ile Val Gly Ile Cys Arg Ile Ser Arg Ile Glu Tyr Gln Gly Ser 
            660                 665                 670         


Ser Arg Pro Ala Tyr Glu Glu Phe Tyr Asn Cys Arg Ser Ile Asp Ser 
        675                 680                 685             


Glu Phe Ser Asn Ala Ile Ala Ser Ile Arg His Ala Arg Phe Gly Lys 
    690                 695                 700                 


Lys Ser Arg Pro Ala Met Tyr Asp Val Ser Pro Ile Ala Tyr Glu Asp 
705                 710                 715                 720 


Tyr Ser Pro Asp Asp Lys Pro Leu Val Thr Leu Ile Lys Thr Lys Asp 
                725                 730                 735     


Leu 
    


<210>  3185
<211>  4753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNHD1__Homo_sapiens__NP_653267

<400>  3185

Met Val Pro Glu Glu Arg Arg Val Gly Leu Ser Ser Asp Glu Thr Ser 
1               5                   10                  15      


Ser Asp Ser Leu Lys Ser Trp His Ser Ile Cys Val Leu Asp Ser Lys 
            20                  25                  30          


Glu Gln Pro Leu Ala Cys Gln Gln Lys Gln Arg Gln Phe Val Lys Pro 
        35                  40                  45              


Val Thr Glu Ser Glu Gln Pro Thr Val Leu Glu Leu Leu Leu Ala Glu 
    50                  55                  60                  


Leu Arg Thr Leu Phe Ser Ala Val Leu Gln Asp Ser Ser Pro Ala Ala 
65                  70                  75                  80  


Trp Arg Tyr Leu His Ala Val Leu Gly Leu Leu Pro Pro Tyr Arg Glu 
                85                  90                  95      


Leu Leu Val Gly His Leu Asp Leu Leu Pro Phe Leu Glu Gln Leu Tyr 
            100                 105                 110         


Cys Trp Ala Pro Trp Val Gln Thr His Leu His Leu Asp Leu Leu Gly 
        115                 120                 125             


Ala Ile Val Gln Ala Phe Pro Pro Asp Ser Ser Leu Leu Asp Ser Ala 
    130                 135                 140                 


Ser His Ala Asp Cys Cys Pro Gln Lys Arg Arg Leu His His Arg Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Cys Pro Phe Val Gln Ala Gln Trp Ser Arg Gln Gln 
                165                 170                 175     


Val Lys Glu Glu Leu Ala Thr Trp Leu Arg Pro Leu Thr Leu Pro Glu 
            180                 185                 190         


Leu Gln Arg Cys Leu Gly Ile Val Gly Ala Gln Val Ala Leu Glu Glu 
        195                 200                 205             


Ala Val Trp Leu Asp Gly Leu Ser Leu Leu Pro Leu Ala Leu Ala Ala 
    210                 215                 220                 


Asp Ile Pro Val Arg Tyr Glu Ser Ser Asp Thr Asp Asn Ala Glu Val 
225                 230                 235                 240 


Glu Pro Val Gly Arg Lys Glu Thr Arg Ser Gln Leu Asp Tyr Glu Val 
                245                 250                 255     


Pro Arg Glu Lys Ala Phe Gln Lys Ser Ser Thr Gly Phe Ser Pro Glu 
            260                 265                 270         


Thr Ser Phe Leu Asp Ser Gln Val Met Thr Ala Leu Lys Met Glu Arg 
        275                 280                 285             


Tyr Leu Lys Lys Ile His Phe Leu Tyr Leu Asn Val Ala Pro Ser Arg 
    290                 295                 300                 


Tyr Phe Arg Pro Tyr Ser Leu Met Val Val Pro Pro Asp Lys Val Asn 
305                 310                 315                 320 


Pro Glu His Tyr Ile Phe Ser Pro Phe Gly Ile Leu His Val His Pro 
                325                 330                 335     


Val Glu Gly Ser Glu Thr Met Thr Leu Gly Thr Trp His His His Cys 
            340                 345                 350         


Val Leu Trp Gln Gln Leu Gln Phe Ile Pro Phe Phe Lys Tyr Cys Leu 
        355                 360                 365             


Leu Arg Lys Ser Phe Thr Cys Trp Lys Lys Asn Val Arg Leu Gln Gly 
    370                 375                 380                 


Leu His Arg Leu Gln Lys Phe Leu Glu Asn His Leu Leu Leu Ala Val 
385                 390                 395                 400 


Pro His Phe Gly Ala Gly Leu Leu His Ile Ser Arg Leu Leu Gln Glu 
                405                 410                 415     


Leu His Ser Val Ser Trp Leu Pro Gln Glu Leu Asp Arg Cys Tyr Glu 
            420                 425                 430         


Leu Leu Asp Leu Gln Thr Ala Leu Ala Glu Glu Lys His Lys Ala Leu 
        435                 440                 445             


Arg Leu Leu His Arg Cys Leu Asn Leu Cys Thr Ser Ile Leu Arg Leu 
    450                 455                 460                 


Val His Glu Asp Thr Tyr His Met Gln Gln Cys Leu Gln Glu Arg Val 
465                 470                 475                 480 


Gln Asn Cys Asp Arg Ile Arg Thr Gly Gln Gly Ser Ile Tyr Leu Gln 
                485                 490                 495     


Arg Val Gln His Lys Gln Leu Glu Gln Lys Leu Lys Gln Ala Glu Ala 
            500                 505                 510         


Trp Trp Leu Gln Leu Gly Lys Phe Ala Arg Leu Val Asp Tyr Met Ile 
        515                 520                 525             


Cys Gln Ser Leu Ile Ser Val Leu Glu Glu Gln Ile Thr Ser Phe Val 
    530                 535                 540                 


Ala Asn Ile Leu Gln Ala Pro Arg Gln Lys Pro Phe Leu Ser Ser Gln 
545                 550                 555                 560 


Leu Val Phe Asp Asp His Gly Gln Leu Ser His Val Pro Cys Val Glu 
                565                 570                 575     


Asn Met Ile Gln Thr Leu Thr Gly Gly Leu Gln Ser Val Lys Thr Ser 
            580                 585                 590         


Ala Leu Gln Val Val Gln Ser Ala Asp Leu Lys Thr Ser Ser Asp Ser 
        595                 600                 605             


Leu Tyr Ser Glu Glu Glu Asp Glu Glu Glu Asp Ser Lys Asp Glu Phe 
    610                 615                 620                 


Leu Met Pro Lys Phe Gln Gly Gln Pro Ser Asp Ala Val Ser Ile Phe 
625                 630                 635                 640 


Cys Gly Pro Asn Val Gly Leu Val Trp Pro Trp Lys Ser His Pro Ile 
                645                 650                 655     


Ala Gly Ile Leu Glu Val Arg Gly Cys Arg Leu Arg Gly Gln Tyr Phe 
            660                 665                 670         


Pro His Asn Tyr Lys Gln Leu Glu Glu Asp Leu Asp Asn Asn Pro Lys 
        675                 680                 685             


Ile Gln Gln Ala Leu Asn Ile Gln Gln Val Leu Leu Glu Gly Val Leu 
    690                 695                 700                 


Cys Lys Val Gln Glu Phe Cys Arg Glu His His Trp Ile Thr Gly Ile 
705                 710                 715                 720 


Tyr Glu Phe Leu Gln Ser Trp Gly Pro Gln Lys Leu Glu Asp Met Arg 
                725                 730                 735     


Gly Gly Pro Ile Lys Asn Tyr Val Thr Leu Val Ser Arg Leu Asn Val 
            740                 745                 750         


Trp Gln Ala Arg Val Ser Ser Met Pro Ile Glu Leu Leu Thr Lys Gly 
        755                 760                 765             


Gly Leu Leu Leu Leu Ser Cys His Asp Val Gln Ala Glu Met Glu Ser 
    770                 775                 780                 


Lys Leu Asn Ser Ile Arg Lys Asp Ile Leu Ala His Val Gln Asn Glu 
785                 790                 795                 800 


Cys Trp Asn Leu Ser Gln Gln Leu Met Thr Glu Leu Thr Asp Phe Met 
                805                 810                 815     


His Ile Phe Arg Thr Ile Asn Ser Asp Ile His Ala Ile Ala Gln Cys 
            820                 825                 830         


Thr Gln Lys Leu Asn Glu Ala Asn Glu Gln Tyr Val Glu Leu Glu Glu 
        835                 840                 845             


Arg Met Glu Tyr Val Arg Ala Leu His Glu Leu Ile Arg Asn His Phe 
    850                 855                 860                 


Ser Leu Phe Ser Ala Glu Asn Glu Ala Leu Asp Ile Ser Val Arg Arg 
865                 870                 875                 880 


Gln Phe Gly Glu Ser Pro Ile Pro Pro Cys Pro Pro Pro Pro Gln Pro 
                885                 890                 895     


His Leu Leu His Cys Pro Leu Leu Ala Pro Gln Leu Leu Asp Met Trp 
            900                 905                 910         


Glu Ala Phe Gln Phe Glu Lys Ser Gln Ala Ser Glu Phe Leu Leu Ser 
        915                 920                 925             


Lys Arg His Ala Ile Met Pro Lys Leu Gln Gln Leu Met Ala Ala Ala 
    930                 935                 940                 


Leu Ala Glu Leu Glu Gly Leu Leu Ala Lys Ala Leu Ser Gly Pro Phe 
945                 950                 955                 960 


Met Asp Pro Thr Gln Asp Gln Arg Ser Thr Glu His Gln Leu Val Ser 
                965                 970                 975     


Leu Glu Arg Gln Phe Gln Asn Thr Val Ser Asp Leu Ser Glu Leu His 
            980                 985                 990         


His Ala Tyr Ala Ile Phe Thr Glu  Asp Glu Thr Pro Val  Pro Leu Pro 
        995                 1000                 1005             


Ile Cys  Gly Thr Arg Pro Ile  Val Gln Gln Gln Arg  Ile Trp His 
    1010                 1015                 1020             


Leu Tyr  Arg Val Ile Ser Glu  Asn Ile Ser Glu Trp  Lys Cys Met 
    1025                 1030                 1035             


Ala Phe  Ala Lys Phe Ser Pro  Ala Met Ala Gln Glu  Lys Thr Glu 
    1040                 1045                 1050             


Gly Trp  Leu Thr Glu Ala Ala  Arg Met Ser Thr Thr  Leu Glu Leu 
    1055                 1060                 1065             


His Ser  Pro Val Leu Gln His  Cys Met Arg Ile Leu  Gly Glu Phe 
    1070                 1075                 1080             


Arg Ser  Tyr Leu Pro Leu Leu  Thr Lys Leu Gly Ser  Leu His Pro 
    1085                 1090                 1095             


Gln Ser  Leu Asn Cys Gln Cys  Leu Leu Arg Ala Leu  Gly Leu Gly 
    1100                 1105                 1110             


Ser Leu  Gln Thr Ile Glu Leu  Leu Thr Leu Gly Gln  Leu Leu Thr 
    1115                 1120                 1125             


Tyr Pro  Leu Leu Glu Phe Ala  Asp Arg Ile Asn Gln  Val Trp Gln 
    1130                 1135                 1140             


Asn Glu  Asn Glu Arg Ile His  Ala Gln Glu Thr Ile  Arg Arg Leu 
    1145                 1150                 1155             


Gln Arg  Tyr Trp Glu Ala Arg  Gln Leu Arg Leu Leu  Asn Phe Ile 
    1160                 1165                 1170             


Leu His  Val Pro Tyr Glu Pro  Pro Ala Ser Glu Arg  Ser Lys Arg 
    1175                 1180                 1185             


Gln Val  Leu Arg Ser Pro Gln  Trp Glu Val Val Asp  Lys Asp Ser 
    1190                 1195                 1200             


Gly Thr  Phe Ile Leu Ser Asp  Tyr Ser Asn Leu Gln  Asp Ser Ile 
    1205                 1210                 1215             


Gln Glu  Ser Leu Gln Val Leu  Ser Lys Ile Leu Ala  Ile Glu Lys 
    1220                 1225                 1230             


Ser Gly  Asp Leu Asn Lys Ile  Ala Leu Glu Trp Val  Ala Ile Met 
    1235                 1240                 1245             


His Gly  Leu Gly Ala Leu Leu  Glu Val Trp Leu Thr  Phe Gln Gln 
    1250                 1255                 1260             


Lys Trp  Ile Phe Leu Asn Lys  Val Leu His Glu Met  Lys Ile Gln 
    1265                 1270                 1275             


Phe Pro  Asn Ala Asp Leu Asn  Ser Arg Phe Lys Val  Met Asp Asp 
    1280                 1285                 1290             


Gln Tyr  Arg Thr Leu Met Arg  Ile Ser Val Ala Asp  Pro Met Val 
    1295                 1300                 1305             


Leu Ser  Leu Val Val Pro Ser  Ala Glu Arg Ser Pro  Tyr Phe Gln 
    1310                 1315                 1320             


Gly Gln  Gln Leu Gln Gln Leu  Leu Gln Ala Gly Ser  Val Glu Leu 
    1325                 1330                 1335             


Glu Gly  Ile Ile Met Ser Leu  Glu Ser Val Leu Tyr  Gly Val Cys 
    1340                 1345                 1350             


Ala His  Phe Pro Arg Leu Phe  Phe Leu Ser Asp Ser  Glu Leu Val 
    1355                 1360                 1365             


Ala Leu  Leu Ala Ala Arg Leu  Glu Ser Cys Glu Ala  Gln Leu Trp 
    1370                 1375                 1380             


Val Arg  Arg Cys Phe Pro His  Val His Ala Val Ser  Phe Arg Ser 
    1385                 1390                 1395             


Cys Pro  Thr Gly Glu Lys Asn  Thr Asp Asp Trp Glu  Ser Ser Pro 
    1400                 1405                 1410             


Asn Thr  Gln Thr Gln Val Glu  Ala Leu Ala Val Leu  Gly Ala Gly 
    1415                 1420                 1425             


Gly Glu  Glu Val Lys Leu Gln  Gly Pro Leu Pro Leu  His Pro Asp 
    1430                 1435                 1440             


Leu Pro  Lys Trp Leu Ala Ser  Leu Glu Lys Cys Leu  Arg Leu Ala 
    1445                 1450                 1455             


Leu Val  His Met Leu Gln Gly  Cys Val Ala Ala Arg  Leu Ala Arg 
    1460                 1465                 1470             


Gly Pro  Ser Leu Gly Glu Ala  Leu Lys Gln Leu Pro  Lys Gln Asn 
    1475                 1480                 1485             


Lys Leu  Tyr Leu Gln Leu Tyr  Val Gln His Trp Ile  Asp Leu Val 
    1490                 1495                 1500             


Gln Ala  Phe Pro Trp Gln Cys  Val Leu Val Ala Glu  Glu Val Val 
    1505                 1510                 1515             


Trp Arg  Ala Glu Met Glu Glu  Ala Leu Leu Glu Trp  Gly Thr Leu 
    1520                 1525                 1530             


Ala Met  Val Ser Met His Met  Arg Lys Leu Glu Val  Leu Val Asn 
    1535                 1540                 1545             


Phe Met  Arg Ala Gln Arg Ala  Ser Gln Gly Gly Gln  Ser Leu Pro 
    1550                 1555                 1560             


Ser Val  Arg Gln Thr Ser Leu  Leu Ser Ala Leu Leu  Val Met Ala 
    1565                 1570                 1575             


Val Thr  His Arg Asp Ile Ala  Gln Leu Leu Glu Gln  His Gln Val 
    1580                 1585                 1590             


Ser Asp  Leu Thr Asp Phe His  Trp Val Arg Gln Leu  Lys Tyr His 
    1595                 1600                 1605             


Leu Gly  Ser Pro His Ile Ile  Pro Lys Ser Pro Leu  Gln Ser Leu 
    1610                 1615                 1620             


Lys Thr  Ile Ala Ser Ser Glu  Pro Ser Leu Ser Pro  Ala Ala Cys 
    1625                 1630                 1635             


Trp Ile  Asp Val Leu Gly Arg  Ser Phe Leu Tyr Asn  Tyr Glu Tyr 
    1640                 1645                 1650             


Leu Gly  Pro Arg Leu Gly Pro  Leu Pro Ser Leu Leu  Pro Glu Arg 
    1655                 1660                 1665             


Pro Ala  Leu Val Leu Leu Leu  Ala Leu Glu Glu Val  Ala Cys Gly 
    1670                 1675                 1680             


Thr Val  Leu Gly Pro Asn Gly  Val Gly Lys Arg Ala  Ile Val Asn 
    1685                 1690                 1695             


Ser Leu  Ala Gln Ala Leu Gly  Arg Gln Leu Val Met  Leu Pro Cys 
    1700                 1705                 1710             


Ser Pro  Gln Ile Glu Ala Gln  Cys Leu Ser Asn Tyr  Leu Asn Gly 
    1715                 1720                 1725             


Ala Leu  Gln Gly Gly Ala Trp  Leu Leu Leu Glu Lys  Val His Gln 
    1730                 1735                 1740             


Leu Pro  Pro Gly Leu Leu Ser  Ala Leu Gly Gln Arg  Leu Gly Glu 
    1745                 1750                 1755             


Leu His  His Leu Tyr Ala Pro  Leu Tyr Gln Glu Ala  Ser Arg Asn 
    1760                 1765                 1770             


Thr Ser  Thr Ile Asp Pro Thr  Gln Pro Gln Leu Leu  Gly Ser Ser 
    1775                 1780                 1785             


Phe Phe  Glu Lys His His Val  Ser Val Arg Leu Gly  Tyr Gly Cys 
    1790                 1795                 1800             


Leu Leu  Val Leu Arg Ala Leu  Ser Ser Ala Val Pro  Ala Asn Leu 
    1805                 1810                 1815             


His Leu  Leu Leu Arg Pro Val  Ala Leu Ala Leu Pro  Asp Leu Arg 
    1820                 1825                 1830             


Gln Val  Ala Glu Leu Thr Leu  Leu Gly Ala Gly Met  Arg Asp Ala 
    1835                 1840                 1845             


Phe Gln  Met Ala Thr Arg Leu  Ser Lys Phe Phe Ser  Leu Glu Arg 
    1850                 1855                 1860             


Glu Leu  Val Ser Gly Pro Leu  Pro Cys Arg Leu Pro  Leu Leu Lys 
    1865                 1870                 1875             


Gln Ile  Leu Glu Asp Thr Ile  Arg Thr Leu Asn Val  Thr Lys Glu 
    1880                 1885                 1890             


Glu Pro  Lys Cys Gln Lys Pro  Arg Ser Leu Ala Ala  Ile Glu Glu 
    1895                 1900                 1905             


Ala Ala  Leu Leu Arg Ser Pro  Leu Phe Ser Ile Leu  Asn Gly Leu 
    1910                 1915                 1920             


His Leu  His Asn Leu Arg Gly  Leu Leu Cys Ala Leu  Phe Pro Ser 
    1925                 1930                 1935             


Ala Ser  Gln Val Leu Ala Glu  Pro Met Thr Tyr Lys  Leu Met Lys 
    1940                 1945                 1950             


Pro Leu  Val Val Glu Glu Leu  Gln Gln Val Gly Leu  Asp Pro Ser 
    1955                 1960                 1965             


Pro Asp  Ile Leu Gly Ser Leu  Glu Gln Leu Ser Gln  Ala Leu Ser 
    1970                 1975                 1980             


Arg Ala  Ser Gly Ile Leu Leu  Leu Gly Pro Ala Gly  Ser Gly Lys 
    1985                 1990                 1995             


Thr Thr  Cys Trp His Ser Leu  Phe Lys Ile Gln Asn  Arg Leu Ala 
    2000                 2005                 2010             


Ala Met  Glu Asp Thr Ser Thr  Gln Gly Cys Gln Pro  Val Glu Ile 
    2015                 2020                 2025             


Thr His  Leu Tyr Pro Ser Gly  Leu Ser Pro Gln Glu  Phe Leu Gly 
    2030                 2035                 2040             


Trp Leu  Glu Gly Ser Cys Trp  His His Gly Ile Phe  Pro Lys Val 
    2045                 2050                 2055             


Leu Arg  Ala Ala Gly Gln Cys  Asn Asn Met Gly Gln  Lys Arg Gln 
    2060                 2065                 2070             


Thr Glu  Glu Ser Ile Gly Ile  Gln His Trp Ile Ile  Cys Asp Gly 
    2075                 2080                 2085             


Ala Ser  Asn Gly Ala Trp Leu  Asp Ser Ile Thr Cys  Leu Leu Ser 
    2090                 2095                 2100             


Glu Leu  Pro Gln Leu Ser Leu  Pro Ser Gly Gln Gln  Ile Ala Arg 
    2105                 2110                 2115             


Pro Pro  Gly Thr Phe Leu Leu  Met Glu Val Ala Asp  Thr Thr Gly 
    2120                 2125                 2130             


Ile Ser  Pro Thr Val Val Gly  Cys Cys Ala Leu Val  Trp Cys Gly 
    2135                 2140                 2145             


Gly Glu  Gln Thr Trp Gln Cys  Ile Leu Ser Ala Leu  Met Ala Ser 
    2150                 2155                 2160             


Leu Pro  Tyr Glu Tyr Arg Leu  Gln His Arg Thr Val  Ala Glu Leu 
    2165                 2170                 2175             


Asn His  Met Ala Glu Val Leu  Val Pro Ala Thr Leu  Arg Phe Leu 
    2180                 2185                 2190             


Thr Cys  Gln Gly Val Ser Ser  Leu Leu Gln Val His  Gly Gln Gln 
    2195                 2200                 2205             


Ala Val  Cys Ala Gly Val Ala  Glu Val Thr Ser Met  Ala Arg Ile 
    2210                 2215                 2220             


Leu His  Ser Leu Leu Asp Leu  His Leu Arg Leu Lys  Glu Glu Lys 
    2225                 2230                 2235             


Ala Pro  Gly Pro Glu Asp Leu  Ser Tyr Ser Asp Pro  Val Ala Gln 
    2240                 2245                 2250             


Ser Phe  Arg Ser Ser Lys Ser  Ser Phe Leu Asn Arg  Ser Gln Val 
    2255                 2260                 2265             


Asp Ser  Asp Asp Val Pro Asp  Lys Cys Arg Glu His  Leu Leu Ala 
    2270                 2275                 2280             


Val Ser  Ser Phe Leu Phe Ala  Leu Ile Trp Gly Phe  Gly Ala His 
    2285                 2290                 2295             


Leu Pro  Ser Arg Phe Trp Pro  Ile Phe Asp Thr Phe  Ile Arg Asp 
    2300                 2305                 2310             


Ser Ile  Ser Arg Leu Ser Asn  Tyr Pro Glu Pro Pro  Pro Ser Ala 
    2315                 2320                 2325             


Leu Val  Phe Asp Leu His Val  Ser Pro Glu Asp Gly  Thr Leu Val 
    2330                 2335                 2340             


Pro Phe  Thr Gly Gln Tyr Leu  Ser Ser His Ile Lys  Gly Thr Leu 
    2345                 2350                 2355             


Gly Thr  Phe His Pro Ser Ile  Gln Thr Glu Arg Leu  Leu Tyr Val 
    2360                 2365                 2370             


Val Asp  Leu Leu Leu Ser Gly  Gly Gln Pro Val Leu  Leu Ala Gly 
    2375                 2380                 2385             


Glu Ala  Ala Thr Gly Lys Ser  Ala Phe Val Glu Val  Leu Val Glu 
    2390                 2395                 2400             


Pro His  His Pro Tyr Ile Tyr  Ser Pro Ile His Pro  Ala Phe Ser 
    2405                 2410                 2415             


Ser Ser  His Leu Arg Leu Leu  Leu Ser Arg Gly Ile  Gln Gly Gln 
    2420                 2425                 2430             


Thr Gln  Ala Ser Pro Gln Pro  Gly His His Gln Asp  Ser Lys Pro 
    2435                 2440                 2445             


Ser Leu  Leu Phe Leu Leu Glu  Asp Leu His Leu Ala  Thr Ser Asp 
    2450                 2455                 2460             


Pro Glu  Lys Ser Cys Gln Pro  Val Leu Glu Thr Leu  Arg Gln Ala 
    2465                 2470                 2475             


Met Asp  Gly Thr Val Tyr Ala  His Ser Thr Leu Glu  Leu Gln Thr 
    2480                 2485                 2490             


Leu Gln  Pro Thr Val Asn Phe  Leu Ala Thr Val Thr  Val Pro Gly 
    2495                 2500                 2505             


Tyr Cys  Glu Arg Pro Leu Cys  Pro Arg Leu Phe Arg  Leu Phe Thr 
    2510                 2515                 2520             


Val Leu  Ala Leu Glu Ser Met  Thr Gln Ala Thr Leu  Leu Glu Arg 
    2525                 2530                 2535             


His Val  Pro Ile Ile Gln Ala  Trp Leu Glu Arg Phe  Pro Ser Val 
    2540                 2545                 2550             


Glu Arg  Glu Arg Ala Leu Ala  Arg Gly Leu Val Arg  Ala Ser Val 
    2555                 2560                 2565             


Glu Ala  Trp Glu Ala Val Cys  Asn Cys Phe Met Pro  Ser Pro Leu 
    2570                 2575                 2580             


His Pro  His Tyr His Phe Ser  Leu His Ser Val Ser  His Leu Leu 
    2585                 2590                 2595             


Ser Ser  Leu Gln Leu Leu Pro  Asn Arg Thr Gly Ser  Arg Gly Phe 
    2600                 2605                 2610             


Val Asp  Tyr Pro Asn His Gln  Glu His Leu Arg Arg  Val Ser Gly 
    2615                 2620                 2625             


Leu Arg  Gly Thr Cys Leu Thr  Val Met Met Ala Thr  Arg Asn Val 
    2630                 2635                 2640             


Val Arg  Leu Trp Leu His Glu  Ala Gln Arg Thr Phe  Cys Asp Arg 
    2645                 2650                 2655             


Leu Asp  Ser Pro Arg Glu Arg  Ser Tyr Cys Ala Lys  Leu Leu Leu 
    2660                 2665                 2670             


Val Val  Ala Gln Ser Val Phe  Cys Cys Gly Pro Gly  Pro Gln His 
    2675                 2680                 2685             


Leu Gly  Lys Asp His Gln Glu  Ser Glu Glu Glu Glu  Glu Glu Glu 
    2690                 2695                 2700             


Arg Val  Pro Glu Val Glu Ser  Glu Gly Glu Leu Ala  Gln Trp Glu 
    2705                 2710                 2715             


Asp Phe  Ser Asn Ser Asn Ser  Glu Thr Glu Glu Glu  Glu Glu Pro 
    2720                 2725                 2730             


Tyr Gly  Leu Gln Val Ala Arg  Val Ser Asn Ser Arg  Asp Pro Ser 
    2735                 2740                 2745             


Leu Thr  Pro Ser Ile Gly Pro  Val Ser Arg Gly Met  Lys Glu Ser 
    2750                 2755                 2760             


Ile Ser  His Lys Ile Arg Gln  Glu Lys Gly Thr Arg  Ala Ser Asn 
    2765                 2770                 2775             


Tyr Arg  Leu Gln Val Arg Arg  Ser Phe Lys Thr Trp  Trp Gln Lys 
    2780                 2785                 2790             


Lys Pro  Gln Met Asp Leu Ile  Ser Pro Leu Leu Leu  Pro Val Leu 
    2795                 2800                 2805             


Leu Leu  His Pro Gln Glu Lys  Pro Ser Asp Leu Val  Phe Ser Gln 
    2810                 2815                 2820             


Glu Leu  Ile Leu Gly Pro Asn  Ser Glu Thr Pro Asn  Leu Tyr Leu 
    2825                 2830                 2835             


Glu Arg  Gln Trp Glu Lys Leu  Glu Glu Gln Leu Ala  Thr Ser Ala 
    2840                 2845                 2850             


Ala Gln  Leu Lys Leu Ser Pro  His Leu Ala Arg Cys  His Ser Met 
    2855                 2860                 2865             


Ala Gln  His Val Ala Arg Leu  Val Arg Val Leu Ala  Arg Pro Arg 
    2870                 2875                 2880             


Gln His  Gly Leu Leu Leu Ser  Gly Ala Leu Gly Thr  Gly Arg His 
    2885                 2890                 2895             


Thr Ala  Ile Thr Leu Ala Ser  Ser Ile Cys Gln Ala  His Phe Phe 
    2900                 2905                 2910             


His Leu  Pro Ser Gly Ser Glu  Glu Ala Ile Leu Gln  Cys Leu Arg 
    2915                 2920                 2925             


Asp Ala  Ser Trp His Ala Gly  Met Leu Ser Gln Pro  Val Ala Leu 
    2930                 2935                 2940             


Leu Val  Pro Ser Gly Val Asp  Leu Thr Thr Leu His  Arg Leu Leu 
    2945                 2950                 2955             


Ala Leu  Ala Thr Ser Gly Ser  Phe Pro Gly Gln Tyr  Thr Glu Ala 
    2960                 2965                 2970             


Asp Leu  Asp Arg Ile Gly Glu  His Leu Pro Arg Glu  Asn Leu Gly 
    2975                 2980                 2985             


Val Lys  Gln Asn Ile Lys Lys  Glu Met Val Leu Gln  Arg Phe His 
    2990                 2995                 3000             


Gln Gln  Val Cys Ser His Leu  His Leu Phe Phe Leu  Ile Gly Asp 
    3005                 3010                 3015             


Lys Gln  Ala His Lys Gln Leu  Pro Ser Thr Leu Phe  Leu Arg Leu 
    3020                 3025                 3030             


Leu Gln  Leu Ala Thr Ala Ser  Ile Asp Arg Tyr Glu  Pro Trp Asp 
    3035                 3040                 3045             


Gln Ala  Ala Leu Ala Lys Val  Ala Gln His His Leu  Glu Gly Ala 
    3050                 3055                 3060             


Gln Ser  Val Pro Leu Asp Asp  Gly Ser Trp Lys Tyr  Pro Asp Leu 
    3065                 3070                 3075             


Gln Ala  Ser Ile Pro Ser Val  Ala Lys Ala Met Ala  Leu Ile His 
    3080                 3085                 3090             


Leu Ser  Ala Thr His Tyr His  Glu His Leu Cys Pro  Ala Leu Pro 
    3095                 3100                 3105             


Leu Val  Thr Pro Lys Thr Phe  Leu Asp Phe Leu Asp  Thr Phe Leu 
    3110                 3115                 3120             


Met Leu  Gln Gln Gln Thr Ile  Leu Lys Ile Lys Asn  Lys Ala Gln 
    3125                 3130                 3135             


Arg Val  Gln Asn Ala Leu Glu  Asn Leu Arg Met Leu  Ile Lys Glu 
    3140                 3145                 3150             


His Gly  Thr His Ala Asn Leu  Ile Phe Asp Leu Glu  Gln Gln Leu 
    3155                 3160                 3165             


Lys Asp  Ser Gly Lys Ser Leu  Ser Met Phe Gln Gln  Gln Leu Glu 
    3170                 3175                 3180             


Gln Ser  Lys Leu Leu Tyr Lys  Gln Gln Leu Glu Glu  Cys Arg His 
    3185                 3190                 3195             


Gln Glu  Asn Leu Ile Glu Asn  Leu Ala Arg Gln Arg  Asp Ala Leu 
    3200                 3205                 3210             


Gln Ala  Gln Arg Glu Ala Phe  Leu Glu Gln Met Ser  Lys Ala Phe 
    3215                 3220                 3225             


Leu Glu  Pro Leu Ser Gln Leu  Gln Val Ala Asp Phe  Glu Glu Ile 
    3230                 3235                 3240             


Arg Ser  Tyr Arg Ala Pro Pro  Glu Ser Val Val Arg  Val Thr Asp 
    3245                 3250                 3255             


Ala Met  Cys Asp Leu Phe His  His Glu Thr Gly Trp  Ala Ser Ala 
    3260                 3265                 3270             


Lys Gln  Leu Leu Cys Thr Glu  Asp Phe Tyr Gln Glu  Leu Val Phe 
    3275                 3280                 3285             


Phe Pro  Lys Glu Lys Ile Thr  Asp Ser Glu Leu Ile  Lys Leu His 
    3290                 3295                 3300             


Leu Ile  Leu Lys Ala Pro Gly  Met Asp Asp Ala Ala  Leu Arg Ala 
    3305                 3310                 3315             


Val Ser  Arg Pro Ala Ala Ser  Leu Ala Ala Trp Leu  Trp Ala Val 
    3320                 3325                 3330             


Leu His  Tyr Gly Leu Ala His  Cys Arg Gly Leu Pro  Thr Asp Leu 
    3335                 3340                 3345             


Leu Leu  Gln Gln Val Glu Ala  Thr Leu Thr Arg Glu  Gln Ala Arg 
    3350                 3355                 3360             


Leu Gly  Tyr Tyr Gln Phe Gln  Ala Gln Glu Thr Leu  Glu His Asn 
    3365                 3370                 3375             


Leu Ala  Leu Ala Lys Met Val  Glu Asp Ala Gln Ala  Ser His Asn 
    3380                 3385                 3390             


Cys Val  Ala Lys Thr Leu Ser  Gln Ala Gln Cys Gly  Gln Tyr His 
    3395                 3400                 3405             


Lys Trp  Pro Met Lys Ala Ala  Leu Leu Thr Pro Met  Arg Ala Trp 
    3410                 3415                 3420             


Thr Thr  Gln Leu Gln Lys Leu  Lys Gly Arg Cys Met  Thr Val Phe 
    3425                 3430                 3435             


Gly Asp  Thr Leu Leu Cys Ser  Ala Ala Ile Ile Tyr  Leu Gly Pro 
    3440                 3445                 3450             


Phe Pro  Pro Leu Arg Arg Gln  Glu Leu Leu Asp Glu  Trp Leu Ala 
    3455                 3460                 3465             


Leu Cys  Arg Gly Phe Gln Glu  Ala Leu Gly Pro Asp  Asp Val Ala 
    3470                 3475                 3480             


Gln Ala  Leu Lys Arg Lys Gln  Lys Ser Val Ser Ile  Pro Pro Lys 
    3485                 3490                 3495             


Asn Pro  Leu Leu Ala Thr His  Ser Pro Phe Ser Ile  Leu Ser Leu 
    3500                 3505                 3510             


Leu Ser  Ser Glu Ser Glu Gln  Tyr Gln Trp Asp Gly  Asn Leu Lys 
    3515                 3520                 3525             


Pro Gln  Ala Lys Ser Ala His  Leu Ala Gly Leu Leu  Leu Arg Ser 
    3530                 3535                 3540             


Pro Thr  His Tyr Ser Ser Cys  Arg Trp Pro Leu Leu  Leu Asp Pro 
    3545                 3550                 3555             


Ser Asn  Glu Ala Leu Ile Trp  Leu Asp Pro Leu Pro  Leu Glu Glu 
    3560                 3565                 3570             


Asn Arg  Ser Phe Ala Pro Ala  Leu Thr Glu Gly Arg  Gly Lys Gly 
    3575                 3580                 3585             


Leu Met  Arg Asn Gln Lys Arg  Glu Ser Lys Thr Asp  Met Lys Glu 
    3590                 3595                 3600             


Glu Asp  Asp Glu Ser Glu Glu  Ser Asn Glu Ala Glu  Asp Gln Thr 
    3605                 3610                 3615             


Lys Glu  Gln Lys Ala Glu Glu  Arg Lys Asn Glu Gln  Glu Lys Glu 
    3620                 3625                 3630             


Gln Glu  Glu Asn Glu Glu Lys  Glu Glu Glu Lys Thr  Glu Ser Gln 
    3635                 3640                 3645             


Gly Ser  Lys Pro Ala Tyr Glu  Thr Gln Leu Pro Ser  Leu Pro Tyr 
    3650                 3655                 3660             


Leu Ser  Val Leu Ser Gly Ala  Asp Pro Glu Leu Gly  Ser Gln Leu 
    3665                 3670                 3675             


Gln Glu  Ala Ala Ala Cys Gly  Leu Pro Val Leu Leu  Thr Asn Val 
    3680                 3685                 3690             


Glu Leu  Gly Leu Gly Cys Glu  Glu Leu Gln Trp Leu  Leu Gln Arg 
    3695                 3700                 3705             


Glu Gln  Leu Ser Pro Pro Gln  Val Gln Pro Gly Phe  Cys Leu Tyr 
    3710                 3715                 3720             


Leu Ser  Thr Thr Leu Ser Leu  Cys Ala Met Glu Lys  Val Leu Gly 
    3725                 3730                 3735             


Cys Glu  Leu Leu Lys Gly Leu  Asn Val Leu Asp Leu  Gly Leu Asn 
    3740                 3745                 3750             


Met Glu  Ile Leu Glu Glu Gln  Met Leu His Glu Ile  Leu Cys Arg 
    3755                 3760                 3765             


Glu Tyr  Pro Glu Leu Glu Thr  Arg Trp Gln Asp Leu  Lys Ile Arg 
    3770                 3775                 3780             


Ala Leu  Asp Thr Cys Lys Ala  Val Glu Ala Ala Glu  Glu Arg Leu 
    3785                 3790                 3795             


Leu Thr  Met Leu Leu Phe Gln  Asn Pro Lys Arg Gln  Lys Pro Ala 
    3800                 3805                 3810             


Lys Phe  Leu Arg Asn Ile Val  Arg Ala Gln Gly Lys  Leu Cys Gln 
    3815                 3820                 3825             


Leu Arg  Ala His Cys Glu Glu  Leu Glu Gly Gln Lys  Leu Gln Glu 
    3830                 3835                 3840             


Met Val  Leu Trp Ala Pro Tyr  Arg Pro Val Val Trp  His Gly Met 
    3845                 3850                 3855             


Ala Met  Val Lys Ala Leu Ser  Gln Leu Gln Asn Leu  Leu Pro Leu 
    3860                 3865                 3870             


Phe Cys  Met Ser Pro Glu Asn  Trp Leu Ala Val Thr  Lys Gln Ala 
    3875                 3880                 3885             


Leu Asp  Ser Met Lys Pro Arg  Glu Ile Asn His Gly  Glu Asp Leu 
    3890                 3895                 3900             


Ala Ser  His Leu Leu Gln Leu  Arg Ala His Leu Thr  Arg Gln Leu 
    3905                 3910                 3915             


Leu Gly  Ser Thr Val Thr Ala  Leu Gly Leu Thr Gln  Val Pro Leu 
    3920                 3925                 3930             


Val Gly  Ala Leu Gly Ala Leu  Ala Leu Leu Gln Ala  Thr Gly Lys 
    3935                 3940                 3945             


Ala Ser  Glu Leu Glu Arg Leu  Ala Leu Trp Pro Gly  Leu Ala Ala 
    3950                 3955                 3960             


Ser Pro  Ser Thr Val His Ser  Lys Pro Val Ser Asp  Val Ala Arg 
    3965                 3970                 3975             


Pro Ala  Trp Leu Gly Pro Lys  Ala Trp His Glu Cys  Glu Met Leu 
    3980                 3985                 3990             


Glu Leu  Leu Pro Pro Phe Val  Gly Leu Cys Ala Ser  Leu Ala Gly 
    3995                 4000                 4005             


His Ser  Ser Ala Trp Gln Ala  Tyr Leu Ser Leu Ser  Ser Thr Val 
    4010                 4015                 4020             


Leu Gly  Pro Ala Pro Gly Pro  Gly Pro Glu Pro Leu  Ser Leu Leu 
    4025                 4030                 4035             


Gln Lys  Leu Ile Leu Trp Arg  Val Leu Arg Pro Glu  Cys Leu Ala 
    4040                 4045                 4050             


Gly Ala  Leu Ala Asp Phe Thr  Thr Ser Leu Leu Gly  Arg Pro Leu 
    4055                 4060                 4065             


Asp Glu  Asn Thr Tyr Ala Pro  Thr Met Pro Phe Lys  His Ser Gln 
    4070                 4075                 4080             


Ala Thr  Gln Pro Met Leu Ile  Leu Leu Pro Pro Pro  Gly His Pro 
    4085                 4090                 4095             


Ser Ala  Thr Leu His Pro Leu  Thr Val Ile Gln Lys  Leu Ala Ala 
    4100                 4105                 4110             


Lys Tyr  Gln Gln Gly Gln Lys  Gln Leu Gln Val Ile  Ala Leu Gly 
    4115                 4120                 4125             


Ser Glu  Ala Trp Asp Pro Val  Ser Val Val Val Ser  Thr Leu Ser 
    4130                 4135                 4140             


Gln Ala  Met Tyr Glu Gly His  Trp Leu Val Leu Asp  Asn Cys His 
    4145                 4150                 4155             


Leu Met  Pro His Trp Pro Lys  Glu Leu Leu Gln Leu  Leu Leu Glu 
    4160                 4165                 4170             


Leu Leu  Gly Arg Ala Lys Val  Val Ala Asp Leu Glu  Ser Glu Gln 
    4175                 4180                 4185             


Leu Leu  Asp Gln Pro Glu Ser  Arg Asn Val Ser Thr  Val His Arg 
    4190                 4195                 4200             


Asp Phe  Arg Leu Trp Leu Ile  Val Pro Ala Glu Ser  Ser Ala Ser 
    4205                 4210                 4215             


Leu Pro  Ala Val Leu Thr Gln  His Ser Met Pro Val  Phe Trp Asn 
    4220                 4225                 4230             


Gln Ser  Leu Glu Leu Gly His  Val Leu Ile Asp Ser  Val Glu Leu 
    4235                 4240                 4245             


Ala Gln  Gln Val Leu Tyr Met  Gln Pro Pro Thr Gln  Ala Leu Pro 
    4250                 4255                 4260             


Leu Leu  Leu Leu His Gly Leu  Leu Leu His Arg Gln  Leu Tyr Gly 
    4265                 4270                 4275             


Thr Arg  Leu Gln Ala His Arg  Gly Arg Trp Ser Gln  Val Thr Leu 
    4280                 4285                 4290             


Thr Gln  Val Leu Gln Thr Gln  Asp Gln Leu Trp Ala  Ser Leu Ser 
    4295                 4300                 4305             


Asn Pro  Arg Ala Ala Met Gln  Glu Leu Ala Ala Ser  Val Phe Tyr 
    4310                 4315                 4320             


Gly Gly  Pro Leu Gly Asp Thr  Glu Asp Arg Glu Ala  Leu Ile Ser 
    4325                 4330                 4335             


Leu Thr  Gln Ala Cys Leu Ser  Pro Ser Ser Gly Ser  Trp Val Gln 
    4340                 4345                 4350             


Pro His  Thr Pro Gln Ser Leu  Leu Ala Thr Leu Met  Pro Leu Pro 
    4355                 4360                 4365             


Glu Leu  Arg Glu Leu Asp Ala  Met Ala Glu Cys Lys  Ala Gln Met 
    4370                 4375                 4380             


His Leu  Leu Pro Ser Pro Pro  Glu Pro Arg Leu Cys  Gly Leu Ser 
    4385                 4390                 4395             


Glu Gly  Pro Gln Ala Trp Leu  Leu Arg Arg Gln Ser  Arg Ala Leu 
    4400                 4405                 4410             


Leu Ser  Ala Leu Gln Arg Ser  Ser Pro Val Trp Val  Pro Glu Ser 
    4415                 4420                 4425             


Arg Arg  Gly Ala Gln Leu Ala  Glu Arg Arg Leu Arg  Gln Arg Leu 
    4430                 4435                 4440             


Val Gln  Val Asn Arg Arg Leu  Glu Ser Leu Gln Asp  Leu Leu Thr 
    4445                 4450                 4455             


His Val  Ile Arg Gln Asp Glu  Ser Asp Ala Pro Trp  Ser Val Leu 
    4460                 4465                 4470             


Gly Pro  Asn Ala Arg Arg Pro  Leu Glu Gly Val Leu  Glu Thr Glu 
    4475                 4480                 4485             


Ala Leu  Glu Leu Ser Gln Leu  Val Gly Thr Leu Gln  Arg Asp Leu 
    4490                 4495                 4500             


Asp Cys  Leu Leu Gln Gln Leu  Lys Gly Ala Pro Pro  Cys Pro Ser 
    4505                 4510                 4515             


Arg Arg  Cys Ala Ala Val Ala  His Ala Leu Trp Thr  Gly Arg Leu 
    4520                 4525                 4530             


Pro Leu  Pro Trp Arg Pro His  Ala Pro Ala Gly Pro  Gln Pro Pro 
    4535                 4540                 4545             


Trp His  Trp Leu Arg Gln Leu  Ser Arg Arg Gly Gln  Leu Leu Val 
    4550                 4555                 4560             


Arg Tyr  Leu Gly Val Gly Ala  Asp Ala Ser Ser Asp  Val Pro Glu 
    4565                 4570                 4575             


Arg Val  Phe His Leu Ser Ala  Phe Arg His Pro Arg  Arg Leu Leu 
    4580                 4585                 4590             


Leu Ala  Leu Arg Gly Glu Ala  Ala Leu Asp Gln Asn  Val Pro Ser 
    4595                 4600                 4605             


Ser Asn  Phe Pro Gly Ser Arg  Gly Ser Val Ser Ser  Gln Leu Gln 
    4610                 4615                 4620             


Tyr Lys  Arg Leu Glu Met Asn  Ser Asn Pro Leu His  Phe Arg Val 
    4625                 4630                 4635             


Glu Asn  Gly Pro Asn Pro Thr  Val Pro Glu Arg Gly  Leu Leu Leu 
    4640                 4645                 4650             


Ile Gly  Leu Gln Val Leu His  Ala Glu Trp Asp Pro  Ile Ala Gly 
    4655                 4660                 4665             


Ala Leu  Gln Asp Ser Pro Ser  Ser Gln Pro Ser Pro  Leu Pro Pro 
    4670                 4675                 4680             


Val Ser  Ile Ser Thr Gln Ala  Pro Gly Thr Ser Asp  Leu Pro Ala 
    4685                 4690                 4695             


Pro Ala  Asp Leu Thr Val Tyr  Ser Cys Pro Val Tyr  Met Gly Gly 
    4700                 4705                 4710             


Pro Leu  Gly Thr Ala Lys Leu  Gln Ser Arg Asn Ile  Val Met His 
    4715                 4720                 4725             


Leu Pro  Leu Pro Thr Lys Leu  Thr Pro Asn Thr Cys  Val Gln Arg 
    4730                 4735                 4740             


Arg Val  His Val Cys Ser Pro  Pro Leu Ser 
    4745                 4750             


<210>  3186
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNLZ__Homo_sapiens__NP_001074318

<400>  3186

Met Leu Arg Thr Ala Leu Arg Gly Ala Pro Arg Leu Leu Ser Arg Val 
1               5                   10                  15      


Gln Pro Arg Ala Pro Cys Leu Arg Arg Leu Trp Gly Arg Gly Ala Arg 
            20                  25                  30          


Pro Glu Val Ala Gly Arg Arg Arg Ala Trp Ala Trp Gly Trp Arg Arg 
        35                  40                  45              


Ser Ser Ser Glu Gln Gly Pro Gly Pro Ala Ala Ala Leu Gly Arg Val 
    50                  55                  60                  


Glu Ala Ala His Tyr Gln Leu Val Tyr Thr Cys Lys Val Cys Gly Thr 
65                  70                  75                  80  


Arg Ser Ser Lys Arg Ile Ser Lys Leu Ala Tyr His Gln Gly Val Val 
                85                  90                  95      


Ile Val Thr Cys Pro Gly Cys Gln Asn His His Ile Ile Ala Asp Asn 
            100                 105                 110         


Leu Gly Trp Phe Ser Asp Leu Asn Gly Lys Arg Asn Ile Glu Glu Ile 
        115                 120                 125             


Leu Thr Ala Arg Gly Glu Gln Val His Arg Val Ala Gly Glu Gly Ala 
    130                 135                 140                 


Leu Glu Leu Val Leu Glu Ala Ala Gly Ala Pro Thr Ser Thr Ala Ala 
145                 150                 155                 160 


Pro Glu Ala Gly Glu Asp Glu Gly Pro Pro Ser Pro Gly Lys Thr Glu 
                165                 170                 175     


Pro Ser 
        


<210>  3187
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNM1__Homo_sapiens__NP_001005336

<400>  3187

Met Gly Asn Arg Gly Met Glu Asp Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Ile Gly Gln Asn Ala Asp Leu Asp Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Asn Ala Thr Thr Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Glu Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
            100                 105                 110         


Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Phe Gln Ile Arg Asp Met Leu 
145                 150                 155                 160 


Met Gln Phe Val Thr Lys Glu Asn Cys Leu Ile Leu Ala Val Ser Pro 
                165                 170                 175     


Ala Asn Ser Asp Leu Ala Asn Ser Asp Ala Leu Lys Val Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Gln Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Thr Ala Ala Leu Ala Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ser Tyr Arg His Leu Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro Tyr Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Gly Leu Arg Asn Lys Leu Gln Ser Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp 
305                 310                 315                 320 


Asp Pro Ala Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Ile Asp 
            340                 345                 350         


Thr Tyr Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Thr Ile Val Lys Lys Gln 
                405                 410                 415     


Val Lys Lys Ile Arg Glu Pro Cys Leu Lys Cys Val Asp Met Val Ile 
            420                 425                 430         


Ser Glu Leu Ile Ser Thr Val Arg Gln Cys Thr Lys Lys Leu Gln Gln 
        435                 440                 445             


Tyr Pro Arg Leu Arg Glu Glu Met Glu Arg Ile Val Thr Thr His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Arg Thr Lys Glu Gln Val Met Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Glu Leu Ala Tyr Met Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Asn Gln Met Asn Lys Lys Lys Thr Ser 
            500                 505                 510         


Gly Asn Gln Asp Glu Ile Leu Val Ile Arg Lys Gly Trp Leu Thr Ile 
        515                 520                 525             


Asn Asn Ile Gly Ile Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val 
    530                 535                 540                 


Leu Thr Ala Glu Asn Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu 
545                 550                 555                 560 


Lys Lys Tyr Met Leu Ser Val Asp Asn Leu Lys Leu Arg Asp Val Glu 
                565                 570                 575     


Lys Gly Phe Met Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu 
            580                 585                 590         


Gln Arg Asn Val Tyr Lys Asp Tyr Arg Gln Leu Glu Leu Ala Cys Glu 
        595                 600                 605             


Thr Gln Glu Glu Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly 
    610                 615                 620                 


Val Tyr Pro Glu Arg Val Gly Asp Lys Glu Lys Ala Ser Glu Thr Glu 
625                 630                 635                 640 


Glu Asn Gly Ser Asp Ser Phe Met His Ser Met Asp Pro Gln Leu Glu 
                645                 650                 655     


Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser Tyr Met Ala Ile 
            660                 665                 670         


Val Asn Lys Thr Val Arg Asp Leu Met Pro Lys Thr Ile Met His Leu 
        675                 680                 685             


Met Ile Asn Asn Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ala Asn 
    690                 695                 700                 


Leu Tyr Ser Cys Gly Asp Gln Asn Thr Leu Met Glu Glu Ser Ala Glu 
705                 710                 715                 720 


Gln Ala Gln Arg Arg Asp Glu Met Leu Arg Met Tyr His Ala Leu Lys 
                725                 730                 735     


Glu Ala Leu Ser Ile Ile Gly Asp Ile Asn Thr Thr Thr Val Ser Thr 
            740                 745                 750         


Pro Met Pro Pro Pro Val Asp Asp Ser Trp Leu Gln Val Gln Ser Val 
        755                 760                 765             


Pro Ala Gly Arg Arg Ser Pro Thr Ser Ser Pro Thr Pro Gln Arg Arg 
    770                 775                 780                 


Ala Pro Ala Val Pro Pro Ala Arg Pro Gly Ser Arg Gly Pro Ala Pro 
785                 790                 795                 800 


Gly Pro Pro Pro Ala Gly Ser Ala Leu Gly Gly Ala Pro Pro Val Pro 
                805                 810                 815     


Ser Arg Pro Gly Ala Ser Pro Asp Pro Phe Gly Pro Pro Pro Gln Val 
            820                 825                 830         


Pro Ser Arg Pro Asn Arg Ala Pro Pro Gly Val Pro Arg Ile Thr Ile 
        835                 840                 845             


Ser Asp Pro 
    850     


<210>  3188
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNM1L__Homo_sapiens__NP_001265392

<400>  3188

Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser 
    530                 535                 540                 


Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Val Ala 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly 
                565                 570                 575     


Asn Trp Arg Gly Met Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala 
            580                 585                 590         


Glu Glu Lys Ser Lys Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys 
        595                 600                 605             


Gly His Ala Val Asn Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys 
    610                 615                 620                 


Leu Ser Ala Arg Glu Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile 
625                 630                 635                 640 


Lys Ser Tyr Phe Leu Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro 
                645                 650                 655     


Lys Ala Val Met His Phe Leu Val Asn His Val Lys Asp Thr Leu Gln 
            660                 665                 670         


Ser Glu Leu Val Gly Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu 
        675                 680                 685             


Leu Thr Glu Ser Glu Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp 
    690                 695                 700                 


Met Leu Lys Ala Leu Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg 
705                 710                 715                 720 


Glu Thr His Leu Trp 
                725 


<210>  3189
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNM2__Homo_sapiens__NP_001005360

<400>  3189

Met Gly Asn Arg Gly Met Glu Glu Leu Ile Pro Leu Val Asn Lys Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ser Ile Gly Gln Ser Cys His Leu Asp Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Ile Leu Gln Leu Ile Phe Ser Lys Thr Glu His 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Ser Lys Lys Phe Thr Asp Phe Asp Glu 
                85                  90                  95      


Val Arg Gln Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
            100                 105                 110         


Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Lys Asp Met Ile 
145                 150                 155                 160 


Leu Gln Phe Ile Ser Arg Glu Ser Ser Leu Ile Leu Ala Val Thr Pro 
                165                 170                 175     


Ala Asn Met Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Glu Gly Lys Lys Asp Ile Arg Ala Ala Leu Ala Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Met Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro His Leu Gln Lys Thr Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Glu Ser Leu Pro Ala Leu Arg Ser Lys Leu Gln Ser Gln Leu 
    290                 295                 300                 


Leu Ser Leu Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp 
305                 310                 315                 320 


Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Gly Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
            340                 345                 350         


Thr Leu Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Asp Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Val Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Leu Ala Phe Glu Ala Ile Val Lys Lys Gln 
                405                 410                 415     


Val Val Lys Leu Lys Glu Pro Cys Leu Lys Cys Val Asp Leu Val Ile 
            420                 425                 430         


Gln Glu Leu Ile Asn Thr Val Arg Gln Cys Thr Ser Lys Leu Ser Ser 
        435                 440                 445             


Tyr Pro Arg Leu Arg Glu Glu Thr Glu Arg Ile Val Thr Thr Tyr Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Arg Thr Lys Asp Gln Ile Leu Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Glu Gln Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Thr Gln Leu Asn Lys Lys Arg Ala Ile 
            500                 505                 510         


Pro Asn Gln Gly Glu Ile Leu Val Ile Arg Arg Gly Trp Leu Thr Ile 
        515                 520                 525             


Asn Asn Ile Ser Leu Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val 
    530                 535                 540                 


Leu Thr Ala Glu Ser Leu Ser Trp Tyr Lys Asp Glu Glu Glu Lys Glu 
545                 550                 555                 560 


Lys Lys Tyr Met Leu Pro Leu Asp Asn Leu Lys Ile Arg Asp Val Glu 
                565                 570                 575     


Lys Gly Phe Met Ser Asn Lys His Val Phe Ala Ile Phe Asn Thr Glu 
            580                 585                 590         


Gln Arg Asn Val Tyr Lys Asp Leu Arg Gln Ile Glu Leu Ala Cys Asp 
        595                 600                 605             


Ser Gln Glu Asp Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly 
    610                 615                 620                 


Val Tyr Pro Glu Lys Asp Gln Ala Glu Asn Glu Asp Gly Ala Gln Glu 
625                 630                 635                 640 


Asn Thr Phe Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile 
                645                 650                 655     


Arg Asn Leu Val Asp Ser Tyr Val Ala Ile Ile Asn Lys Ser Ile Arg 
            660                 665                 670         


Asp Leu Met Pro Lys Thr Ile Met His Leu Met Ile Asn Asn Thr Lys 
        675                 680                 685             


Ala Phe Ile His His Glu Leu Leu Ala Tyr Leu Tyr Ser Ser Ala Asp 
    690                 695                 700                 


Gln Ser Ser Leu Met Glu Glu Ser Ala Asp Gln Ala Gln Arg Arg Asp 
705                 710                 715                 720 


Asp Met Leu Arg Met Tyr His Ala Leu Lys Glu Ala Leu Asn Ile Ile 
                725                 730                 735     


Gly Asp Ile Ser Thr Ser Thr Val Ser Thr Pro Val Pro Pro Pro Val 
            740                 745                 750         


Asp Asp Thr Trp Leu Gln Ser Ala Ser Ser His Ser Pro Thr Pro Gln 
        755                 760                 765             


Arg Arg Pro Val Ser Ser Ile His Pro Pro Gly Arg Pro Pro Ala Val 
    770                 775                 780                 


Arg Gly Pro Thr Pro Gly Pro Pro Leu Ile Pro Val Pro Val Gly Ala 
785                 790                 795                 800 


Ala Ala Ser Phe Ser Ala Pro Pro Ile Pro Ser Arg Pro Gly Pro Gln 
                805                 810                 815     


Ser Val Phe Ala Asn Ser Asp Leu Phe Pro Ala Pro Pro Gln Ile Pro 
            820                 825                 830         


Ser Arg Pro Val Arg Ile Pro Pro Gly Ile Pro Pro Gly Val Pro Ser 
        835                 840                 845             


Arg Arg Pro Pro Ala Ala Pro Ser Arg Pro Thr Ile Ile Arg Pro Ala 
    850                 855                 860                 


Glu Pro Ser Leu Leu Asp 
865                 870 


<210>  3190
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNM3__Homo_sapiens__NP_001129599

<400>  3190

Met Gly Asn Arg Glu Met Glu Glu Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Leu Gly Gln Ser Cys Leu Leu Glu Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Thr Ser Lys Ala Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Asp Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Met Asn 
            100                 105                 110         


Lys Gly Ile Ser Ser Ile Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Ile Asp Leu Pro Gly Ile Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Tyr Gln Ile Arg Glu Met Ile 
145                 150                 155                 160 


Met Gln Phe Ile Thr Arg Glu Asn Cys Leu Ile Leu Ala Val Thr Pro 
                165                 170                 175     


Ala Asn Thr Asp Leu Ala Asn Ser Asp Ala Leu Lys Leu Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Leu Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Val Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Lys Ala Ala Met Leu Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ala Tyr Arg His Ile Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro His Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Asn Phe Arg Asn Lys Leu Gln Gly Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu His Glu Val Glu Ala Tyr Lys Asn Phe Lys Pro Glu 
305                 310                 315                 320 


Asp Pro Thr Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Val Asp 
            340                 345                 350         


Thr Leu Glu Leu Ser Gly Gly Ala Lys Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Ile Val Lys Met Glu Phe Asn Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Ala Ile Val Lys Lys Gln 
                405                 410                 415     


Ile Val Lys Leu Lys Gly Pro Ser Leu Lys Ser Val Asp Leu Val Ile 
            420                 425                 430         


Gln Glu Leu Ile Asn Thr Val Lys Lys Cys Thr Lys Lys Leu Ala Asn 
        435                 440                 445             


Phe Pro Arg Leu Cys Glu Glu Thr Glu Arg Ile Val Ala Asn His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Lys Thr Lys Asp Gln Val Leu Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Gln Val Ser Tyr Ile Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Ser Gln Val His Lys Lys Thr Thr Val 
            500                 505                 510         


Gly Asn Gln Val Ile Arg Lys Gly Trp Leu Thr Ile Ser Asn Ile Gly 
        515                 520                 525             


Ile Met Lys Gly Gly Ser Lys Gly Tyr Trp Phe Val Leu Thr Ala Glu 
    530                 535                 540                 


Ser Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met 
545                 550                 555                 560 


Leu Pro Leu Asp Asn Leu Lys Val Arg Asp Val Glu Lys Ser Phe Met 
                565                 570                 575     


Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu Gln Arg Asn Val 
            580                 585                 590         


Tyr Lys Asp Tyr Arg Phe Leu Glu Leu Ala Cys Asp Ser Gln Glu Asp 
        595                 600                 605             


Val Asp Ser Trp Lys Ala Ser Leu Leu Arg Ala Gly Val Tyr Pro Asp 
    610                 615                 620                 


Lys Ser Val Ala Glu Asn Asp Glu Asn Gly Gln Ala Glu Asn Phe Ser 
625                 630                 635                 640 


Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg Asn Leu Val 
                645                 650                 655     


Asp Ser Tyr Met Ser Ile Ile Asn Lys Cys Ile Arg Asp Leu Ile Pro 
            660                 665                 670         


Lys Thr Ile Met His Leu Met Ile Asn Asn Val Lys Asp Phe Ile Asn 
        675                 680                 685             


Ser Glu Leu Leu Ala Gln Leu Tyr Ser Ser Glu Asp Gln Asn Thr Leu 
    690                 695                 700                 


Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp Glu Met Leu Arg 
705                 710                 715                 720 


Met Tyr Gln Ala Leu Lys Glu Ala Leu Gly Ile Ile Gly Asp Ile Ser 
                725                 730                 735     


Thr Ala Thr Val Ser Thr Pro Ala Pro Pro Pro Val Asp Asp Ser Trp 
            740                 745                 750         


Ile Gln His Ser Arg Arg Ser Pro Pro Pro Ser Pro Thr Thr Gln Arg 
        755                 760                 765             


Arg Pro Thr Leu Ser Ala Pro Leu Ala Arg Pro Thr Ser Gly Arg Gly 
    770                 775                 780                 


Pro Ala Pro Ala Ile Pro Ser Pro Gly Pro His Ser Gly Ala Pro Pro 
785                 790                 795                 800 


Val Pro Phe Arg Pro Gly Pro Leu Pro Pro Phe Pro Ser Ser Ser Asp 
                805                 810                 815     


Ser Phe Gly Ala Pro Pro Gln Val Pro Ser Arg Pro Thr Arg Ala Pro 
            820                 825                 830         


Pro Ser Val Pro Ser Arg Arg Pro Pro Pro Ser Pro Thr Arg Pro Thr 
        835                 840                 845             


Ile Ile Arg Pro Leu Glu Ser Ser Leu Leu Asp 
    850                 855                 


<210>  3191
<211>  1577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNMBP__Homo_sapiens__NP_056036

<400>  3191

Met Glu Ala Gly Ser Val Val Arg Ala Ile Phe Asp Phe Cys Pro Ser 
1               5                   10                  15      


Val Ser Glu Glu Leu Pro Leu Phe Val Gly Asp Ile Ile Glu Val Leu 
            20                  25                  30          


Ala Val Val Asp Glu Phe Trp Leu Leu Gly Lys Lys Glu Asp Val Thr 
        35                  40                  45              


Gly Gln Phe Pro Ser Ser Phe Val Glu Ile Val Thr Ile Pro Ser Leu 
    50                  55                  60                  


Lys Glu Gly Glu Arg Leu Phe Val Cys Ile Cys Glu Phe Thr Ser Gln 
65                  70                  75                  80  


Glu Leu Asp Asn Leu Pro Leu His Arg Gly Asp Leu Val Ile Leu Asp 
                85                  90                  95      


Gly Ile Pro Thr Ala Gly Trp Leu Gln Gly Arg Ser Cys Trp Gly Ala 
            100                 105                 110         


Arg Gly Phe Phe Pro Ser Ser Cys Val Arg Glu Leu Cys Leu Ser Ser 
        115                 120                 125             


Gln Ser Arg Gln Trp His Ser Gln Ser Ala Leu Phe Gln Ile Pro Glu 
    130                 135                 140                 


Tyr Ser Met Gly Gln Ala Arg Ala Leu Met Gly Leu Ser Ala Gln Leu 
145                 150                 155                 160 


Asp Glu Glu Leu Asp Phe Arg Glu Gly Asp Val Ile Thr Ile Ile Gly 
                165                 170                 175     


Val Pro Glu Pro Gly Trp Phe Glu Gly Glu Leu Glu Gly Arg Arg Gly 
            180                 185                 190         


Ile Phe Pro Glu Gly Phe Val Glu Leu Leu Gly Pro Leu Arg Thr Val 
        195                 200                 205             


Asp Glu Ser Val Ser Ser Gly Asn Gln Asp Asp Cys Ile Val Asn Gly 
    210                 215                 220                 


Glu Val Asp Thr Pro Val Gly Glu Glu Glu Ile Gly Pro Asp Glu Asp 
225                 230                 235                 240 


Glu Glu Glu Pro Gly Thr Tyr Gly Val Ala Leu Tyr Arg Phe Gln Ala 
                245                 250                 255     


Leu Glu Pro Asn Glu Leu Asp Phe Glu Val Gly Asp Lys Ile Arg Ile 
            260                 265                 270         


Leu Ala Thr Leu Glu Asp Gly Trp Leu Glu Gly Ser Leu Lys Gly Arg 
        275                 280                 285             


Thr Gly Ile Phe Pro Tyr Arg Phe Val Lys Leu Cys Pro Asp Thr Arg 
    290                 295                 300                 


Val Glu Glu Thr Met Ala Leu Pro Gln Glu Gly Ser Leu Ala Arg Ile 
305                 310                 315                 320 


Pro Glu Thr Ser Leu Asp Cys Leu Glu Asn Thr Leu Gly Val Glu Glu 
                325                 330                 335     


Gln Arg His Glu Thr Ser Asp His Glu Ala Glu Glu Pro Asp Cys Ile 
            340                 345                 350         


Ile Ser Glu Ala Pro Thr Ser Pro Leu Gly His Leu Thr Ser Glu Tyr 
        355                 360                 365             


Asp Thr Asp Arg Asn Ser Tyr Gln Asp Glu Asp Thr Ala Gly Gly Pro 
    370                 375                 380                 


Pro Arg Ser Pro Gly Val Glu Trp Glu Met Pro Leu Ala Thr Asp Ser 
385                 390                 395                 400 


Pro Thr Ser Asp Pro Thr Glu Val Val Asn Gly Ile Ser Ser Gln Pro 
                405                 410                 415     


Gln Val Pro Phe His Pro Asn Leu Gln Lys Ser Gln Tyr Tyr Ser Thr 
            420                 425                 430         


Val Gly Gly Ser His Pro His Ser Glu Gln Tyr Pro Asp Leu Leu Pro 
        435                 440                 445             


Leu Glu Ala Arg Thr Arg Asp Tyr Ala Ser Leu Pro Pro Lys Arg Met 
    450                 455                 460                 


Tyr Ser Gln Leu Lys Thr Leu Gln Lys Pro Val Leu Pro Leu Tyr Arg 
465                 470                 475                 480 


Gly Ser Ser Val Ser Ala Ser Arg Val Val Lys Pro Arg Gln Ser Ser 
                485                 490                 495     


Pro Gln Leu His Asn Leu Ala Ser Tyr Thr Lys Lys His His Thr Ser 
            500                 505                 510         


Ser Val Tyr Ser Ile Ser Glu Arg Leu Glu Met Lys Pro Gly Pro Gln 
        515                 520                 525             


Ala Gln Gly Leu Val Met Glu Ala Ala Thr His Ser Gln Gly Asp Gly 
    530                 535                 540                 


Ser Thr Asp Leu Asp Ser Lys Leu Thr Gln Gln Leu Ile Glu Phe Glu 
545                 550                 555                 560 


Lys Ser Leu Ala Gly Pro Gly Thr Glu Pro Asp Lys Ile Leu Arg His 
                565                 570                 575     


Phe Ser Ile Met Asp Phe Asn Ser Glu Lys Asp Ile Val Arg Gly Ser 
            580                 585                 590         


Ser Lys Leu Ile Thr Glu Gln Glu Leu Pro Glu Arg Arg Lys Ala Leu 
        595                 600                 605             


Arg Pro Pro Pro Pro Arg Pro Cys Thr Pro Val Ser Thr Ser Pro His 
    610                 615                 620                 


Leu Leu Val Asp Gln Asn Leu Lys Pro Ala Pro Pro Leu Val Val Arg 
625                 630                 635                 640 


Pro Ser Arg Pro Ala Pro Leu Pro Pro Ser Ala Gln Gln Arg Thr Asn 
                645                 650                 655     


Ala Val Ser Pro Lys Leu Leu Ser Arg His Arg Pro Thr Cys Glu Thr 
            660                 665                 670         


Leu Glu Lys Glu Gly Pro Gly His Met Gly Arg Ser Leu Asp Gln Thr 
        675                 680                 685             


Ser Pro Cys Pro Leu Val Leu Val Arg Ile Glu Glu Met Glu Arg Asp 
    690                 695                 700                 


Leu Asp Met Tyr Ser Arg Ala Gln Glu Glu Leu Asn Leu Met Leu Glu 
705                 710                 715                 720 


Glu Lys Gln Asp Glu Ser Ser Arg Ala Glu Thr Leu Glu Asp Leu Lys 
                725                 730                 735     


Phe Cys Glu Ser Asn Ile Glu Ser Leu Asn Met Glu Leu Gln Gln Leu 
            740                 745                 750         


Arg Glu Met Thr Leu Leu Ser Ser Gln Ser Ser Ser Leu Val Ala Pro 
        755                 760                 765             


Ser Gly Ser Val Ser Ala Glu Asn Pro Glu Gln Arg Met Leu Glu Lys 
    770                 775                 780                 


Arg Ala Lys Val Ile Glu Glu Leu Leu Gln Thr Glu Arg Asp Tyr Ile 
785                 790                 795                 800 


Arg Asp Leu Glu Met Cys Ile Glu Arg Ile Met Val Pro Met Gln Gln 
                805                 810                 815     


Ala Gln Val Pro Asn Ile Asp Phe Glu Gly Leu Phe Gly Asn Met Gln 
            820                 825                 830         


Met Val Ile Lys Val Ser Lys Gln Leu Leu Ala Ala Leu Glu Ile Ser 
        835                 840                 845             


Asp Ala Val Gly Pro Val Phe Leu Gly His Arg Asp Glu Leu Glu Gly 
    850                 855                 860                 


Thr Tyr Lys Ile Tyr Cys Gln Asn His Asp Glu Ala Ile Ala Leu Leu 
865                 870                 875                 880 


Glu Ile Tyr Glu Lys Asp Glu Lys Ile Gln Lys His Leu Gln Asp Ser 
                885                 890                 895     


Leu Ala Asp Leu Lys Ser Leu Tyr Asn Glu Trp Gly Cys Thr Asn Tyr 
            900                 905                 910         


Ile Asn Leu Gly Ser Phe Leu Ile Lys Pro Val Gln Arg Val Met Arg 
        915                 920                 925             


Tyr Pro Leu Leu Leu Met Glu Leu Leu Asn Ser Thr Pro Glu Ser His 
    930                 935                 940                 


Pro Asp Lys Val Pro Leu Thr Asn Ala Val Leu Ala Val Lys Glu Ile 
945                 950                 955                 960 


Asn Val Asn Ile Asn Glu Tyr Lys Arg Arg Lys Asp Leu Val Leu Lys 
                965                 970                 975     


Tyr Arg Lys Gly Asp Glu Asp Ser Leu Met Glu Lys Ile Ser Lys Leu 
            980                 985                 990         


Asn Ile His Ser Ile Ile Lys Lys  Ser Asn Arg Val Ser  Ser His Leu 
        995                 1000                 1005             


Lys His  Leu Thr Gly Phe Ala  Pro Gln Ile Lys Asp  Glu Val Phe 
    1010                 1015                 1020             


Glu Glu  Thr Glu Lys Asn Phe  Arg Met Gln Glu Arg  Leu Ile Lys 
    1025                 1030                 1035             


Ser Phe  Ile Arg Asp Leu Ser  Leu Tyr Leu Gln His  Ile Arg Glu 
    1040                 1045                 1050             


Ser Ala  Cys Val Lys Val Val  Ala Ala Val Ser Met  Trp Asp Val 
    1055                 1060                 1065             


Cys Met  Glu Arg Gly His Arg  Asp Leu Glu Gln Phe  Glu Arg Val 
    1070                 1075                 1080             


His Arg  Tyr Ile Ser Asp Gln  Leu Phe Thr Asn Phe  Lys Glu Arg 
    1085                 1090                 1095             


Thr Glu  Arg Leu Val Ile Ser  Pro Leu Asn Gln Leu  Leu Ser Met 
    1100                 1105                 1110             


Phe Thr  Gly Pro His Lys Leu  Val Gln Lys Arg Phe  Asp Lys Leu 
    1115                 1120                 1125             


Leu Asp  Phe Tyr Asn Cys Thr  Glu Arg Ala Glu Lys  Leu Lys Asp 
    1130                 1135                 1140             


Lys Lys  Thr Leu Glu Glu Leu  Gln Ser Ala Arg Asn  Asn Tyr Glu 
    1145                 1150                 1155             


Ala Leu  Asn Ala Gln Leu Leu  Asp Glu Leu Pro Lys  Phe His Gln 
    1160                 1165                 1170             


Tyr Ala  Gln Gly Leu Phe Thr  Asn Cys Val His Gly  Tyr Ala Glu 
    1175                 1180                 1185             


Ala His  Cys Asp Phe Val His  Gln Ala Leu Glu Gln  Leu Lys Pro 
    1190                 1195                 1200             


Leu Leu  Ser Leu Leu Lys Val  Ala Gly Arg Glu Gly  Asn Leu Ile 
    1205                 1210                 1215             


Ala Ile  Phe His Glu Glu His  Ser Arg Val Leu Gln  Gln Leu Gln 
    1220                 1225                 1230             


Val Phe  Thr Phe Phe Pro Glu  Ser Leu Pro Ala Thr  Lys Lys Pro 
    1235                 1240                 1245             


Phe Glu  Arg Lys Thr Ile Asp  Arg Gln Ser Ala Arg  Lys Pro Leu 
    1250                 1255                 1260             


Leu Gly  Leu Pro Ser Tyr Met  Leu Gln Ser Glu Glu  Leu Arg Ala 
    1265                 1270                 1275             


Ser Leu  Leu Ala Arg Tyr Pro  Pro Glu Lys Leu Phe  Gln Ala Glu 
    1280                 1285                 1290             


Arg Asn  Phe Asn Ala Ala Gln  Asp Leu Asp Val Ser  Leu Leu Glu 
    1295                 1300                 1305             


Gly Asp  Leu Val Gly Val Ile  Lys Lys Lys Asp Pro  Met Gly Ser 
    1310                 1315                 1320             


Gln Asn  Arg Trp Leu Ile Asp  Asn Gly Val Thr Lys  Gly Phe Val 
    1325                 1330                 1335             


Tyr Ser  Ser Phe Leu Lys Pro  Tyr Asn Pro Arg Arg  Ser His Ser 
    1340                 1345                 1350             


Asp Ala  Ser Val Gly Ser His  Ser Ser Thr Glu Ser  Glu His Gly 
    1355                 1360                 1365             


Ser Ser  Ser Pro Arg Phe Pro  Arg Gln Asn Ser Gly  Ser Thr Leu 
    1370                 1375                 1380             


Thr Phe  Asn Pro Ser Ser Met  Ala Val Ser Phe Thr  Ser Gly Ser 
    1385                 1390                 1395             


Cys Gln  Lys Gln Pro Gln Asp  Ala Ser Pro Pro Pro  Lys Glu Cys 
    1400                 1405                 1410             


Asp Gln  Gly Thr Leu Ser Ala  Ser Leu Asn Pro Ser  Asn Ser Glu 
    1415                 1420                 1425             


Ser Ser  Pro Ser Arg Cys Pro  Ser Asp Pro Asp Ser  Thr Ser Gln 
    1430                 1435                 1440             


Pro Arg  Ser Gly Asp Ser Ala  Asp Val Ala Arg Asp  Val Lys Gln 
    1445                 1450                 1455             


Pro Thr  Ala Thr Pro Arg Ser  Tyr Arg Asn Phe Arg  His Pro Glu 
    1460                 1465                 1470             


Ile Val  Gly Tyr Ser Val Pro  Gly Arg Asn Gly Gln  Ser Gln Asp 
    1475                 1480                 1485             


Leu Val  Lys Gly Cys Ala Arg  Thr Ala Gln Ala Pro  Glu Asp Arg 
    1490                 1495                 1500             


Ser Thr  Glu Pro Asp Gly Ser  Glu Ala Glu Gly Asn  Gln Val Tyr 
    1505                 1510                 1515             


Phe Ala  Val Tyr Thr Phe Lys  Ala Arg Asn Pro Asn  Glu Leu Ser 
    1520                 1525                 1530             


Val Ser  Ala Asn Gln Lys Leu  Lys Ile Leu Glu Phe  Lys Asp Val 
    1535                 1540                 1545             


Thr Gly  Asn Thr Glu Trp Trp  Leu Ala Glu Val Asn  Gly Lys Lys 
    1550                 1555                 1560             


Gly Tyr  Val Pro Ser Asn Tyr  Ile Arg Lys Thr Glu  Tyr Thr 
    1565                 1570                 1575         


<210>  3192
<211>  1632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNMT1__Homo_sapiens__NP_001124295

<400>  3192

Met Pro Ala Arg Thr Ala Pro Ala Arg Val Pro Thr Leu Ala Val Pro 
1               5                   10                  15      


Ala Ile Ser Leu Pro Asp Asp Val Arg Arg Arg Leu Lys Asp Leu Glu 
            20                  25                  30          


Arg Asp Ser Leu Thr Glu Lys Glu Cys Val Lys Glu Lys Leu Asn Leu 
        35                  40                  45              


Leu His Glu Phe Leu Gln Thr Glu Ile Lys Asn Gln Leu Cys Asp Leu 
    50                  55                  60                  


Glu Thr Lys Leu Arg Lys Glu Glu Leu Ser Glu Glu Gly Tyr Leu Ala 
65                  70                  75                  80  


Lys Val Lys Ser Leu Leu Asn Lys Asp Leu Ser Leu Glu Asn Gly Ala 
                85                  90                  95      


His Ala Tyr Asn Arg Glu Val Asn Gly Arg Leu Glu Asn Gly Asn Gln 
            100                 105                 110         


Ala Arg Ser Glu Ala Arg Arg Val Gly Met Ala Asp Ala Asn Ser Pro 
        115                 120                 125             


Pro Lys Pro Leu Ser Lys Pro Arg Thr Pro Arg Arg Ser Lys Ser Asp 
    130                 135                 140                 


Gly Glu Ala Lys Arg Ser Arg Asp Pro Pro Ala Ser Ala Ser Gln Val 
145                 150                 155                 160 


Thr Gly Ile Arg Ala Glu Pro Ser Pro Ser Pro Arg Ile Thr Arg Lys 
                165                 170                 175     


Ser Thr Arg Gln Thr Thr Ile Thr Ser His Phe Ala Lys Gly Pro Ala 
            180                 185                 190         


Lys Arg Lys Pro Gln Glu Glu Ser Glu Arg Ala Lys Ser Asp Glu Ser 
        195                 200                 205             


Ile Lys Glu Glu Asp Lys Asp Gln Asp Glu Lys Arg Arg Arg Val Thr 
    210                 215                 220                 


Ser Arg Glu Arg Val Ala Arg Pro Leu Pro Ala Glu Glu Pro Glu Arg 
225                 230                 235                 240 


Ala Lys Ser Gly Thr Arg Thr Glu Lys Glu Glu Glu Arg Asp Glu Lys 
                245                 250                 255     


Glu Glu Lys Arg Leu Arg Ser Gln Thr Lys Glu Pro Thr Pro Lys Gln 
            260                 265                 270         


Lys Leu Lys Glu Glu Pro Asp Arg Glu Ala Arg Ala Gly Val Gln Ala 
        275                 280                 285             


Asp Glu Asp Glu Asp Gly Asp Glu Lys Asp Glu Lys Lys His Arg Ser 
    290                 295                 300                 


Gln Pro Lys Asp Leu Ala Ala Lys Arg Arg Pro Glu Glu Lys Glu Pro 
305                 310                 315                 320 


Glu Lys Val Asn Pro Gln Ile Ser Asp Glu Lys Asp Glu Asp Glu Lys 
                325                 330                 335     


Glu Glu Lys Arg Arg Lys Thr Thr Pro Lys Glu Pro Thr Glu Lys Lys 
            340                 345                 350         


Met Ala Arg Ala Lys Thr Val Met Asn Ser Lys Thr His Pro Pro Lys 
        355                 360                 365             


Cys Ile Gln Cys Gly Gln Tyr Leu Asp Asp Pro Asp Leu Lys Tyr Gly 
    370                 375                 380                 


Gln His Pro Pro Asp Ala Val Asp Glu Pro Gln Met Leu Thr Asn Glu 
385                 390                 395                 400 


Lys Leu Ser Ile Phe Asp Ala Asn Glu Ser Gly Phe Glu Ser Tyr Glu 
                405                 410                 415     


Ala Leu Pro Gln His Lys Leu Thr Cys Phe Ser Val Tyr Cys Lys His 
            420                 425                 430         


Gly His Leu Cys Pro Ile Asp Thr Gly Leu Ile Glu Lys Asn Ile Glu 
        435                 440                 445             


Leu Phe Phe Ser Gly Ser Ala Lys Pro Ile Tyr Asp Asp Asp Pro Ser 
    450                 455                 460                 


Leu Glu Gly Gly Val Asn Gly Lys Asn Leu Gly Pro Ile Asn Glu Trp 
465                 470                 475                 480 


Trp Ile Thr Gly Phe Asp Gly Gly Glu Lys Ala Leu Ile Gly Phe Ser 
                485                 490                 495     


Thr Ser Phe Ala Glu Tyr Ile Leu Met Asp Pro Ser Pro Glu Tyr Ala 
            500                 505                 510         


Pro Ile Phe Gly Leu Met Gln Glu Lys Ile Tyr Ile Ser Lys Ile Val 
        515                 520                 525             


Val Glu Phe Leu Gln Ser Asn Ser Asp Ser Thr Tyr Glu Asp Leu Ile 
    530                 535                 540                 


Asn Lys Ile Glu Thr Thr Val Pro Pro Ser Gly Leu Asn Leu Asn Arg 
545                 550                 555                 560 


Phe Thr Glu Asp Ser Leu Leu Arg His Ala Gln Phe Val Val Glu Gln 
                565                 570                 575     


Val Glu Ser Tyr Asp Glu Ala Gly Asp Ser Asp Glu Gln Pro Ile Phe 
            580                 585                 590         


Leu Thr Pro Cys Met Arg Asp Leu Ile Lys Leu Ala Gly Val Thr Leu 
        595                 600                 605             


Gly Gln Arg Arg Ala Gln Ala Arg Arg Gln Thr Ile Arg His Ser Thr 
    610                 615                 620                 


Arg Glu Lys Asp Arg Gly Pro Thr Lys Ala Thr Thr Thr Lys Leu Val 
625                 630                 635                 640 


Tyr Gln Ile Phe Asp Thr Phe Phe Ala Glu Gln Ile Glu Lys Asp Asp 
                645                 650                 655     


Arg Glu Asp Lys Glu Asn Ala Phe Lys Arg Arg Arg Cys Gly Val Cys 
            660                 665                 670         


Glu Val Cys Gln Gln Pro Glu Cys Gly Lys Cys Lys Ala Cys Lys Asp 
        675                 680                 685             


Met Val Lys Phe Gly Gly Ser Gly Arg Ser Lys Gln Ala Cys Gln Glu 
    690                 695                 700                 


Arg Arg Cys Pro Asn Met Ala Met Lys Glu Ala Asp Asp Asp Glu Glu 
705                 710                 715                 720 


Val Asp Asp Asn Ile Pro Glu Met Pro Ser Pro Lys Lys Met His Gln 
                725                 730                 735     


Gly Lys Lys Lys Lys Gln Asn Lys Asn Arg Ile Ser Trp Val Gly Glu 
            740                 745                 750         


Ala Val Lys Thr Asp Gly Lys Lys Ser Tyr Tyr Lys Lys Val Cys Ile 
        755                 760                 765             


Asp Ala Glu Thr Leu Glu Val Gly Asp Cys Val Ser Val Ile Pro Asp 
    770                 775                 780                 


Asp Ser Ser Lys Pro Leu Tyr Leu Ala Arg Val Thr Ala Leu Trp Glu 
785                 790                 795                 800 


Asp Ser Ser Asn Gly Gln Met Phe His Ala His Trp Phe Cys Ala Gly 
                805                 810                 815     


Thr Asp Thr Val Leu Gly Ala Thr Ser Asp Pro Leu Glu Leu Phe Leu 
            820                 825                 830         


Val Asp Glu Cys Glu Asp Met Gln Leu Ser Tyr Ile His Ser Lys Val 
        835                 840                 845             


Lys Val Ile Tyr Lys Ala Pro Ser Glu Asn Trp Ala Met Glu Gly Gly 
    850                 855                 860                 


Met Asp Pro Glu Ser Leu Leu Glu Gly Asp Asp Gly Lys Thr Tyr Phe 
865                 870                 875                 880 


Tyr Gln Leu Trp Tyr Asp Gln Asp Tyr Ala Arg Phe Glu Ser Pro Pro 
                885                 890                 895     


Lys Thr Gln Pro Thr Glu Asp Asn Lys Phe Lys Phe Cys Val Ser Cys 
            900                 905                 910         


Ala Arg Leu Ala Glu Met Arg Gln Lys Glu Ile Pro Arg Val Leu Glu 
        915                 920                 925             


Gln Leu Glu Asp Leu Asp Ser Arg Val Leu Tyr Tyr Ser Ala Thr Lys 
    930                 935                 940                 


Asn Gly Ile Leu Tyr Arg Val Gly Asp Gly Val Tyr Leu Pro Pro Glu 
945                 950                 955                 960 


Ala Phe Thr Phe Asn Ile Lys Leu Ser Ser Pro Val Lys Arg Pro Arg 
                965                 970                 975     


Lys Glu Pro Val Asp Glu Asp Leu Tyr Pro Glu His Tyr Arg Lys Tyr 
            980                 985                 990         


Ser Asp Tyr Ile Lys Gly Ser Asn  Leu Asp Ala Pro Glu  Pro Tyr Arg 
        995                 1000                 1005             


Ile Gly  Arg Ile Lys Glu Ile  Phe Cys Pro Lys Lys  Ser Asn Gly 
    1010                 1015                 1020             


Arg Pro  Asn Glu Thr Asp Ile  Lys Ile Arg Val Asn  Lys Phe Tyr 
    1025                 1030                 1035             


Arg Pro  Glu Asn Thr His Lys  Ser Thr Pro Ala Ser  Tyr His Ala 
    1040                 1045                 1050             


Asp Ile  Asn Leu Leu Tyr Trp  Ser Asp Glu Glu Ala  Val Val Asp 
    1055                 1060                 1065             


Phe Lys  Ala Val Gln Gly Arg  Cys Thr Val Glu Tyr  Gly Glu Asp 
    1070                 1075                 1080             


Leu Pro  Glu Cys Val Gln Val  Tyr Ser Met Gly Gly  Pro Asn Arg 
    1085                 1090                 1095             


Phe Tyr  Phe Leu Glu Ala Tyr  Asn Ala Lys Ser Lys  Ser Phe Glu 
    1100                 1105                 1110             


Asp Pro  Pro Asn His Ala Arg  Ser Pro Gly Asn Lys  Gly Lys Gly 
    1115                 1120                 1125             


Lys Gly  Lys Gly Lys Gly Lys  Pro Lys Ser Gln Ala  Cys Glu Pro 
    1130                 1135                 1140             


Ser Glu  Pro Glu Ile Glu Ile  Lys Leu Pro Lys Leu  Arg Thr Leu 
    1145                 1150                 1155             


Asp Val  Phe Ser Gly Cys Gly  Gly Leu Ser Glu Gly  Phe His Gln 
    1160                 1165                 1170             


Ala Gly  Ile Ser Asp Thr Leu  Trp Ala Ile Glu Met  Trp Asp Pro 
    1175                 1180                 1185             


Ala Ala  Gln Ala Phe Arg Leu  Asn Asn Pro Gly Ser  Thr Val Phe 
    1190                 1195                 1200             


Thr Glu  Asp Cys Asn Ile Leu  Leu Lys Leu Val Met  Ala Gly Glu 
    1205                 1210                 1215             


Thr Thr  Asn Ser Arg Gly Gln  Arg Leu Pro Gln Lys  Gly Asp Val 
    1220                 1225                 1230             


Glu Met  Leu Cys Gly Gly Pro  Pro Cys Gln Gly Phe  Ser Gly Met 
    1235                 1240                 1245             


Asn Arg  Phe Asn Ser Arg Thr  Tyr Ser Lys Phe Lys  Asn Ser Leu 
    1250                 1255                 1260             


Val Val  Ser Phe Leu Ser Tyr  Cys Asp Tyr Tyr Arg  Pro Arg Phe 
    1265                 1270                 1275             


Phe Leu  Leu Glu Asn Val Arg  Asn Phe Val Ser Phe  Lys Arg Ser 
    1280                 1285                 1290             


Met Val  Leu Lys Leu Thr Leu  Arg Cys Leu Val Arg  Met Gly Tyr 
    1295                 1300                 1305             


Gln Cys  Thr Phe Gly Val Leu  Gln Ala Gly Gln Tyr  Gly Val Ala 
    1310                 1315                 1320             


Gln Thr  Arg Arg Arg Ala Ile  Ile Leu Ala Ala Ala  Pro Gly Glu 
    1325                 1330                 1335             


Lys Leu  Pro Leu Phe Pro Glu  Pro Leu His Val Phe  Ala Pro Arg 
    1340                 1345                 1350             


Ala Cys  Gln Leu Ser Val Val  Val Asp Asp Lys Lys  Phe Val Ser 
    1355                 1360                 1365             


Asn Ile  Thr Arg Leu Ser Ser  Gly Pro Phe Arg Thr  Ile Thr Val 
    1370                 1375                 1380             


Arg Asp  Thr Met Ser Asp Leu  Pro Glu Val Arg Asn  Gly Ala Ser 
    1385                 1390                 1395             


Ala Leu  Glu Ile Ser Tyr Asn  Gly Glu Pro Gln Ser  Trp Phe Gln 
    1400                 1405                 1410             


Arg Gln  Leu Arg Gly Ala Gln  Tyr Gln Pro Ile Leu  Arg Asp His 
    1415                 1420                 1425             


Ile Cys  Lys Asp Met Ser Ala  Leu Val Ala Ala Arg  Met Arg His 
    1430                 1435                 1440             


Ile Pro  Leu Ala Pro Gly Ser  Asp Trp Arg Asp Leu  Pro Asn Ile 
    1445                 1450                 1455             


Glu Val  Arg Leu Ser Asp Gly  Thr Met Ala Arg Lys  Leu Arg Tyr 
    1460                 1465                 1470             


Thr His  His Asp Arg Lys Asn  Gly Arg Ser Ser Ser  Gly Ala Leu 
    1475                 1480                 1485             


Arg Gly  Val Cys Ser Cys Val  Glu Ala Gly Lys Ala  Cys Asp Pro 
    1490                 1495                 1500             


Ala Ala  Arg Gln Phe Asn Thr  Leu Ile Pro Trp Cys  Leu Pro His 
    1505                 1510                 1515             


Thr Gly  Asn Arg His Asn His  Trp Ala Gly Leu Tyr  Gly Arg Leu 
    1520                 1525                 1530             


Glu Trp  Asp Gly Phe Phe Ser  Thr Thr Val Thr Asn  Pro Glu Pro 
    1535                 1540                 1545             


Met Gly  Lys Gln Gly Arg Val  Leu His Pro Glu Gln  His Arg Val 
    1550                 1555                 1560             


Val Ser  Val Arg Glu Cys Ala  Arg Ser Gln Gly Phe  Pro Asp Thr 
    1565                 1570                 1575             


Tyr Arg  Leu Phe Gly Asn Ile  Leu Asp Lys His Arg  Gln Val Gly 
    1580                 1585                 1590             


Asn Ala  Val Pro Pro Pro Leu  Ala Lys Ala Ile Gly  Leu Glu Ile 
    1595                 1600                 1605             


Lys Leu  Cys Met Leu Ala Lys  Ala Arg Glu Ser Ala  Ser Ala Lys 
    1610                 1615                 1620             


Ile Lys  Glu Glu Glu Ala Ala  Lys Asp 
    1625                 1630         


<210>  3193
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNMT3A__Homo_sapiens__NP_715640

<400>  3193

Met Gly Ile Leu Glu Arg Val Val Arg Arg Asn Gly Arg Val Asp Arg 
1               5                   10                  15      


Ser Leu Lys Asp Glu Cys Asp Thr Ala Glu Lys Lys Ala Lys Val Ile 
            20                  25                  30          


Ala Gly Met Asn Ala Val Glu Glu Asn Gln Gly Pro Gly Glu Ser Gln 
        35                  40                  45              


Lys Val Glu Glu Ala Ser Pro Pro Ala Val Gln Gln Pro Thr Asp Pro 
    50                  55                  60                  


Ala Ser Pro Thr Val Ala Thr Thr Pro Glu Pro Val Gly Ser Asp Ala 
65                  70                  75                  80  


Gly Asp Lys Asn Ala Thr Lys Ala Gly Asp Asp Glu Pro Glu Tyr Glu 
                85                  90                  95      


Asp Gly Arg Gly Phe Gly Ile Gly Glu Leu Val Trp Gly Lys Leu Arg 
            100                 105                 110         


Gly Phe Ser Trp Trp Pro Gly Arg Ile Val Ser Trp Trp Met Thr Gly 
        115                 120                 125             


Arg Ser Arg Ala Ala Glu Gly Thr Arg Trp Val Met Trp Phe Gly Asp 
    130                 135                 140                 


Gly Lys Phe Ser Val Val Cys Val Glu Lys Leu Met Pro Leu Ser Ser 
145                 150                 155                 160 


Phe Cys Ser Ala Phe His Gln Ala Thr Tyr Asn Lys Gln Pro Met Tyr 
                165                 170                 175     


Arg Lys Ala Ile Tyr Glu Val Leu Gln Val Ala Ser Ser Arg Ala Gly 
            180                 185                 190         


Lys Leu Phe Pro Val Cys His Asp Ser Asp Glu Ser Asp Thr Ala Lys 
        195                 200                 205             


Ala Val Glu Val Gln Asn Lys Pro Met Ile Glu Trp Ala Leu Gly Gly 
    210                 215                 220                 


Phe Gln Pro Ser Gly Pro Lys Gly Leu Glu Pro Pro Glu Glu Glu Lys 
225                 230                 235                 240 


Asn Pro Tyr Lys Glu Val Tyr Thr Asp Met Trp Val Glu Pro Glu Ala 
                245                 250                 255     


Ala Ala Tyr Ala Pro Pro Pro Pro Ala Lys Lys Pro Arg Lys Ser Thr 
            260                 265                 270         


Ala Glu Lys Pro Lys Val Lys Glu Ile Ile Asp Glu Arg Thr Arg Glu 
        275                 280                 285             


Arg Leu Val Tyr Glu Val Arg Gln Lys Cys Arg Asn Ile Glu Asp Ile 
    290                 295                 300                 


Cys Ile Ser Cys Gly Ser Leu Asn Val Thr Leu Glu His Pro Leu Phe 
305                 310                 315                 320 


Val Gly Gly Met Cys Gln Asn Cys Lys Asn Cys Phe Leu Glu Cys Ala 
                325                 330                 335     


Tyr Gln Tyr Asp Asp Asp Gly Tyr Gln Ser Tyr Cys Thr Ile Cys Cys 
            340                 345                 350         


Gly Gly Arg Glu Val Leu Met Cys Gly Asn Asn Asn Cys Cys Arg Cys 
        355                 360                 365             


Phe Cys Val Glu Cys Val Asp Leu Leu Val Gly Pro Gly Ala Ala Gln 
    370                 375                 380                 


Ala Ala Ile Lys Glu Asp Pro Trp Asn Cys Tyr Met Cys Gly His Lys 
385                 390                 395                 400 


Gly Thr Tyr Gly Leu Leu Arg Arg Arg Glu Asp Trp Pro Ser Arg Leu 
                405                 410                 415     


Gln Met Phe Phe Ala Asn Asn His Asp Gln Glu Phe Asp Pro Pro Lys 
            420                 425                 430         


Val Tyr Pro Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu 
        435                 440                 445             


Ser Leu Phe Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu 
    450                 455                 460                 


Gly Ile Gln Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser 
465                 470                 475                 480 


Ile Thr Val Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly 
                485                 490                 495     


Asp Val Arg Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe 
            500                 505                 510         


Asp Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn 
        515                 520                 525             


Pro Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu 
    530                 535                 540                 


Phe Tyr Arg Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg 
545                 550                 555                 560 


Pro Phe Phe Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp 
                565                 570                 575     


Lys Arg Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp 
            580                 585                 590         


Ala Lys Glu Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn 
        595                 600                 605             


Leu Pro Gly Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu 
    610                 615                 620                 


Glu Leu Gln Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys 
625                 630                 635                 640 


Val Arg Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp 
                645                 650                 655     


Gln His Phe Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys 
            660                 665                 670         


Thr Glu Met Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val 
        675                 680                 685             


Ser Asn Met Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp 
    690                 695                 700                 


Ser Val Pro Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe 
705                 710                 715                 720 


Ala Cys Val 
            


<210>  3194
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNMT3B__Homo_sapiens__NP_001193984

<400>  3194

Met Lys Gly Asp Thr Arg His Leu Asn Gly Glu Glu Asp Ala Gly Gly 
1               5                   10                  15      


Arg Glu Asp Ser Ile Leu Val Asn Gly Ala Cys Ser Asp Gln Ser Ser 
            20                  25                  30          


Asp Ser Pro Pro Ile Leu Glu Ala Ile Arg Thr Pro Glu Ile Arg Gly 
        35                  40                  45              


Arg Arg Ser Ser Ser Arg Leu Ser Lys Arg Glu Val Ser Ser Leu Leu 
    50                  55                  60                  


Ser Tyr Thr Gln Asp Leu Thr Gly Asp Gly Asp Gly Glu Asp Gly Asp 
65                  70                  75                  80  


Gly Ser Asp Thr Pro Val Met Pro Lys Leu Phe Arg Glu Thr Arg Thr 
                85                  90                  95      


Arg Ser Glu Ser Pro Ala Ser Leu Arg Arg Arg Ala Thr Ala Ser Ala 
            100                 105                 110         


Gly Thr Pro Trp Pro Ser Pro Pro Ser Ser Tyr Leu Thr Ile Asp Leu 
        115                 120                 125             


Thr Asp Asp Thr Glu Asp Thr His Gly Thr Pro Gln Ser Ser Ser Thr 
    130                 135                 140                 


Pro Tyr Ala Arg Leu Ala Gln Asp Ser Gln Gln Gly Gly Met Glu Ser 
145                 150                 155                 160 


Pro Gln Val Glu Ala Asp Ser Gly Asp Gly Asp Ser Ser Glu Tyr Gln 
                165                 170                 175     


Asp Gly Lys Glu Phe Gly Ile Gly Asp Leu Val Trp Gly Lys Ile Lys 
            180                 185                 190         


Gly Phe Ser Trp Trp Pro Ala Met Val Val Ser Trp Lys Ala Thr Ser 
        195                 200                 205             


Lys Arg Gln Ala Met Ser Gly Met Arg Trp Val Gln Trp Phe Gly Asp 
    210                 215                 220                 


Gly Lys Phe Ser Glu Val Ser Ala Asp Lys Leu Val Ala Leu Gly Leu 
225                 230                 235                 240 


Phe Ser Gln His Phe Asn Leu Ala Thr Phe Asn Lys Leu Val Ser Tyr 
                245                 250                 255     


Arg Lys Ala Met Tyr His Ala Leu Glu Lys Ala Arg Val Arg Ala Gly 
            260                 265                 270         


Lys Thr Phe Pro Ser Ser Pro Gly Asp Ser Leu Glu Asp Gln Leu Lys 
        275                 280                 285             


Pro Met Leu Glu Trp Ala His Gly Gly Phe Lys Pro Thr Gly Ile Glu 
    290                 295                 300                 


Gly Leu Lys Pro Asn Asn Thr Gln Pro Glu Asn Lys Thr Arg Arg Arg 
305                 310                 315                 320 


Thr Ala Asp Asp Ser Ala Thr Ser Asp Tyr Cys Pro Ala Pro Lys Arg 
                325                 330                 335     


Leu Lys Thr Asn Cys Tyr Asn Asn Gly Lys Asp Arg Gly Asp Glu Asp 
            340                 345                 350         


Gln Ser Arg Glu Gln Met Ala Ser Asp Val Ala Asn Asn Lys Ser Ser 
        355                 360                 365             


Leu Glu Asp Gly Cys Leu Ser Cys Gly Arg Lys Asn Pro Val Ser Phe 
    370                 375                 380                 


His Pro Leu Phe Glu Gly Gly Leu Cys Gln Thr Cys Arg Asp Arg Phe 
385                 390                 395                 400 


Leu Glu Leu Phe Tyr Met Tyr Asp Asp Asp Gly Tyr Gln Ser Tyr Cys 
                405                 410                 415     


Thr Val Cys Cys Glu Gly Arg Glu Leu Leu Leu Cys Ser Asn Thr Ser 
            420                 425                 430         


Cys Cys Arg Cys Phe Cys Val Glu Cys Leu Glu Val Leu Val Gly Thr 
        435                 440                 445             


Gly Thr Ala Ala Glu Ala Lys Leu Gln Glu Pro Trp Ser Cys Tyr Met 
    450                 455                 460                 


Cys Leu Pro Gln Arg Cys His Gly Val Leu Arg Arg Arg Lys Asp Trp 
465                 470                 475                 480 


Asn Val Arg Leu Gln Ala Phe Phe Thr Ser Asp Thr Gly Leu Glu Tyr 
                485                 490                 495     


Glu Ala Pro Lys Leu Tyr Pro Ala Ile Pro Ala Ala Arg Arg Arg Pro 
            500                 505                 510         


Ile Arg Val Leu Ser Leu Phe Asp Gly Ile Ala Thr Gly Tyr Leu Val 
        515                 520                 525             


Leu Lys Glu Leu Gly Ile Lys Val Gly Lys Tyr Val Ala Ser Glu Val 
    530                 535                 540                 


Cys Glu Glu Ser Ile Ala Val Gly Thr Val Lys His Glu Gly Asn Ile 
545                 550                 555                 560 


Lys Tyr Val Asn Asp Val Arg Asn Ile Thr Lys Lys Asn Ile Glu Glu 
                565                 570                 575     


Trp Gly Pro Phe Asp Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu 
            580                 585                 590         


Ser Asn Val Asn Pro Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg 
        595                 600                 605             


Leu Phe Phe Glu Phe Tyr His Leu Leu Asn Tyr Ser Arg Pro Lys Glu 
    610                 615                 620                 


Gly Asp Asp Arg Pro Phe Phe Trp Met Phe Glu Asn Val Val Ala Met 
625                 630                 635                 640 


Lys Val Gly Asp Lys Arg Asp Ile Ser Arg Phe Leu Glu Cys Asn Pro 
                645                 650                 655     


Val Met Ile Asp Ala Ile Lys Val Ser Ala Ala His Arg Ala Arg Tyr 
            660                 665                 670         


Phe Trp Gly Asn Leu Pro Gly Met Asn Arg Ile Phe Gly Phe Pro Val 
        675                 680                 685             


His Tyr Thr Asp Val Ser Asn Met Gly Arg Gly Ala Arg Gln Lys Leu 
    690                 695                 700                 


Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg His Leu Phe Ala Pro 
705                 710                 715                 720 


Leu Lys Asp Tyr Phe Ala Cys Glu 
                725             


<210>  3195
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNMT3L__Homo_sapiens__NP_787063

<400>  3195

Met Ala Ala Ile Pro Ala Leu Asp Pro Glu Ala Glu Pro Ser Met Asp 
1               5                   10                  15      


Val Ile Leu Val Gly Ser Ser Glu Leu Ser Ser Ser Val Ser Pro Gly 
            20                  25                  30          


Thr Gly Arg Asp Leu Ile Ala Tyr Glu Val Lys Ala Asn Gln Arg Asn 
        35                  40                  45              


Ile Glu Asp Ile Cys Ile Cys Cys Gly Ser Leu Gln Val His Thr Gln 
    50                  55                  60                  


His Pro Leu Phe Glu Gly Gly Ile Cys Ala Pro Cys Lys Asp Lys Phe 
65                  70                  75                  80  


Leu Asp Ala Leu Phe Leu Tyr Asp Asp Asp Gly Tyr Gln Ser Tyr Cys 
                85                  90                  95      


Ser Ile Cys Cys Ser Gly Glu Thr Leu Leu Ile Cys Gly Asn Pro Asp 
            100                 105                 110         


Cys Thr Arg Cys Tyr Cys Phe Glu Cys Val Asp Ser Leu Val Gly Pro 
        115                 120                 125             


Gly Thr Ser Gly Lys Val His Ala Met Ser Asn Trp Val Cys Tyr Leu 
    130                 135                 140                 


Cys Leu Pro Ser Ser Arg Ser Gly Leu Leu Gln Arg Arg Arg Lys Trp 
145                 150                 155                 160 


Arg Ser Gln Leu Lys Ala Phe Tyr Asp Arg Glu Ser Glu Asn Pro Leu 
                165                 170                 175     


Glu Met Phe Glu Thr Val Pro Val Trp Arg Arg Gln Pro Val Arg Val 
            180                 185                 190         


Leu Ser Leu Phe Glu Asp Ile Lys Lys Glu Leu Thr Ser Leu Gly Phe 
        195                 200                 205             


Leu Glu Ser Gly Ser Asp Pro Gly Gln Leu Lys His Val Val Asp Val 
    210                 215                 220                 


Thr Asp Thr Val Arg Lys Asp Val Glu Glu Trp Gly Pro Phe Asp Leu 
225                 230                 235                 240 


Val Tyr Gly Ala Thr Pro Pro Leu Gly His Thr Cys Asp Arg Pro Pro 
                245                 250                 255     


Ser Trp Tyr Leu Phe Gln Phe His Arg Leu Leu Gln Tyr Ala Arg Pro 
            260                 265                 270         


Lys Pro Gly Ser Pro Arg Pro Phe Phe Trp Met Phe Val Asp Asn Leu 
        275                 280                 285             


Val Leu Asn Lys Glu Asp Leu Asp Val Ala Ser Arg Phe Leu Glu Met 
    290                 295                 300                 


Glu Pro Val Thr Ile Pro Asp Val His Gly Gly Ser Leu Gln Asn Ala 
305                 310                 315                 320 


Val Arg Val Trp Ser Asn Ile Pro Ala Ile Arg Ser Arg His Trp Ala 
                325                 330                 335     


Leu Val Ser Glu Glu Glu Leu Ser Leu Leu Ala Gln Asn Lys Gln Ser 
            340                 345                 350         


Ser Lys Leu Ala Ala Lys Trp Pro Thr Lys Leu Val Lys Asn Cys Phe 
        355                 360                 365             


Leu Pro Leu Arg Glu Tyr Phe Lys Tyr Phe Ser Thr Glu Leu Thr Ser 
    370                 375                 380                 


Ser Leu 
385     


<210>  3196
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNPEP__Homo_sapiens__NP_036232

<400>  3196

Met Ser Gly His Ser Pro Thr Arg Gly Ala Met Gln Val Ala Met Asn 
1               5                   10                  15      


Gly Lys Ala Arg Lys Glu Ala Val Gln Thr Ala Ala Lys Glu Leu Leu 
            20                  25                  30          


Lys Phe Val Asn Arg Ser Pro Ser Pro Phe His Ala Val Ala Glu Cys 
        35                  40                  45              


Arg Asn Arg Leu Leu Gln Ala Gly Phe Ser Glu Leu Lys Glu Thr Glu 
    50                  55                  60                  


Lys Trp Asn Ile Lys Pro Glu Ser Lys Tyr Phe Met Thr Arg Asn Ser 
65                  70                  75                  80  


Ser Thr Ile Ile Ala Phe Ala Val Gly Gly Gln Tyr Val Pro Gly Asn 
                85                  90                  95      


Gly Phe Ser Leu Ile Gly Ala His Thr Asp Ser Pro Cys Leu Arg Val 
            100                 105                 110         


Lys Arg Arg Ser Arg Arg Ser Gln Val Gly Phe Gln Gln Val Gly Val 
        115                 120                 125             


Glu Thr Tyr Gly Gly Gly Ile Trp Ser Thr Trp Phe Asp Arg Asp Leu 
    130                 135                 140                 


Thr Leu Ala Gly Arg Val Ile Val Lys Cys Pro Thr Ser Gly Arg Leu 
145                 150                 155                 160 


Glu Gln Gln Leu Val His Val Glu Arg Pro Ile Leu Arg Ile Pro His 
                165                 170                 175     


Leu Ala Ile His Leu Gln Arg Asn Ile Asn Glu Asn Phe Gly Pro Asn 
            180                 185                 190         


Thr Glu Met His Leu Val Pro Ile Leu Ala Thr Ala Ile Gln Glu Glu 
        195                 200                 205             


Leu Glu Lys Gly Thr Pro Glu Pro Gly Pro Leu Asn Ala Val Asp Glu 
    210                 215                 220                 


Arg His His Ser Val Leu Met Ser Leu Leu Cys Ala His Leu Gly Leu 
225                 230                 235                 240 


Ser Pro Lys Asp Ile Val Glu Met Glu Leu Cys Leu Ala Asp Thr Gln 
                245                 250                 255     


Pro Ala Val Leu Gly Gly Ala Tyr Asp Glu Phe Ile Phe Ala Pro Arg 
            260                 265                 270         


Leu Asp Asn Leu His Ser Cys Phe Cys Ala Leu Gln Ala Leu Ile Asp 
        275                 280                 285             


Ser Cys Ala Gly Pro Gly Ser Leu Ala Thr Glu Pro His Val Arg Met 
    290                 295                 300                 


Val Thr Leu Tyr Asp Asn Glu Glu Val Gly Ser Glu Ser Ala Gln Gly 
305                 310                 315                 320 


Ala Gln Ser Leu Leu Thr Glu Leu Val Leu Arg Arg Ile Ser Ala Ser 
                325                 330                 335     


Cys Gln His Pro Thr Ala Phe Glu Glu Ala Ile Pro Lys Ser Phe Met 
            340                 345                 350         


Ile Ser Ala Asp Met Ala His Ala Val His Pro Asn Tyr Leu Asp Lys 
        355                 360                 365             


His Glu Glu Asn His Arg Pro Leu Phe His Lys Gly Pro Val Ile Lys 
    370                 375                 380                 


Val Asn Ser Lys Gln Arg Tyr Ala Ser Asn Ala Val Ser Glu Ala Leu 
385                 390                 395                 400 


Ile Arg Glu Val Ala Asn Lys Val Lys Val Pro Leu Gln Asp Leu Met 
                405                 410                 415     


Val Arg Asn Asp Thr Pro Cys Gly Thr Thr Ile Gly Pro Ile Leu Ala 
            420                 425                 430         


Ser Arg Leu Gly Leu Arg Val Leu Asp Leu Gly Ser Pro Gln Leu Ala 
        435                 440                 445             


Met His Ser Ile Arg Glu Met Ala Cys Thr Thr Gly Val Leu Gln Thr 
    450                 455                 460                 


Leu Thr Leu Phe Lys Gly Phe Phe Glu Leu Phe Pro Ser Leu Ser His 
465                 470                 475                 480 


Asn Leu Leu Val Asp 
                485 


<210>  3197
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DNTT__Homo_sapiens__NP_001017520

<400>  3197

Met Asp Pro Pro Arg Ala Ser His Leu Ser Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Thr Gly Ala Leu Met Ala Ser Ser Pro Gln Asp Ile Lys Phe 
            20                  25                  30          


Gln Asp Leu Val Val Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Leu Glu Trp Leu Gln Ala Gln Lys Val Gln Val Ser 
                85                  90                  95      


Ser Gln Pro Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Ile Arg 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Thr Gly Lys His Gln Leu Val Val Arg 
        115                 120                 125             


Arg Asp Tyr Ser Asp Ser Thr Asn Pro Gly Pro Pro Lys Thr Pro Pro 
    130                 135                 140                 


Ile Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Cys Asn Gln Ile Phe Thr Asp Ala Phe Asp Ile Leu Ala 
                165                 170                 175     


Glu Asn Cys Glu Phe Arg Glu Asn Glu Asp Ser Cys Val Thr Phe Met 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Ser Lys Val Lys Gly Ile 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Thr Leu Ser Lys Val Arg Ser Asp Lys Ser Leu Lys Phe Thr Arg Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Ser Val Leu Val Lys Glu Ala Val Trp 
305                 310                 315                 320 


Ala Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Lys Met Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Ser Thr Glu Asp Glu Glu Gln Leu Leu Gln Lys Val Met Asn Leu Trp 
        355                 360                 365             


Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe 
    370                 375                 380                 


Glu Lys Leu Arg Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
385                 390                 395                 400 


Gln Lys Cys Phe Leu Ile Phe Lys Leu Pro Arg Gln Arg Val Asp Ser 
                405                 410                 415     


Asp Gln Ser Ser Trp Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val 
            420                 425                 430         


Asp Leu Val Leu Cys Pro Tyr Glu Arg Arg Ala Phe Ala Leu Leu Gly 
        435                 440                 445             


Trp Thr Gly Ser Arg Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr His 
    450                 455                 460                 


Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys 
465                 470                 475                 480 


Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His Leu 
                485                 490                 495     


Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505             


<210>  3198
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOC2A__Homo_sapiens__XP_011544277

<400>  3198

Met Arg Gly Arg Arg Gly Asp Arg Met Thr Ile Asn Ile Gln Glu His 
1               5                   10                  15      


Met Ala Ile Asn Val Cys Pro Gly Pro Ile Arg Pro Ile Arg Gln Ile 
            20                  25                  30          


Ser Asp Tyr Phe Pro Arg Gly Pro Gly Pro Glu Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Glu Ala Pro Ala His Leu Val Pro Leu Ala Leu Ala Pro Pro 
    50                  55                  60                  


Ala Ala Leu Leu Gly Ala Thr Thr Pro Glu Asp Gly Ala Glu Val Asp 
65                  70                  75                  80  


Ser Tyr Asp Ser Asp Asp Ala Thr Ala Leu Gly Thr Leu Glu Phe Asp 
                85                  90                  95      


Leu Leu Tyr Asp Arg Ala Ser Cys Thr Leu His Cys Ser Ile Leu Arg 
            100                 105                 110         


Ala Lys Gly Leu Lys Pro Met Asp Phe Asn Gly Leu Ala Asp Pro Tyr 
        115                 120                 125             


Val Lys Leu His Leu Leu Pro Gly Ala Cys Lys Ala Asn Lys Leu Lys 
    130                 135                 140                 


Thr Lys Thr Gln Arg Asn Thr Leu Asn Pro Val Trp Asn Glu Asp Leu 
145                 150                 155                 160 


Thr Tyr Ser Gly Ile Thr Asp Asp Asp Ile Thr His Lys Val Leu Arg 
                165                 170                 175     


Ile Ala Val Cys Asp Glu Asp Lys Leu Ser His Asn Glu Phe Ile Gly 
            180                 185                 190         


Glu Ile Arg Val Pro Leu Arg Arg Leu Lys Pro Ser Gln Lys Lys His 
        195                 200                 205             


Phe Asn Ile Cys Leu Glu Arg Gln Val Pro Leu Ala Ser Pro Ser Ser 
    210                 215                 220                 


Met Ser Ala Ala Leu Arg Gly Ile Ser Cys Tyr Leu Lys Glu Leu Glu 
225                 230                 235                 240 


Gln Ala Glu Gln Gly Gln Gly Leu Leu Glu Glu Arg Gly Arg Ile Leu 
                245                 250                 255     


Leu Ser Leu Ser Tyr Ser Ser Arg Arg Arg Gly Leu Leu Val Gly Ile 
            260                 265                 270         


Leu Arg Cys Ala His Leu Ala Ala Met Asp Val Asn Gly Tyr Ser Asp 
        275                 280                 285             


Pro Tyr Val Lys Thr Tyr Leu Arg Pro Asp Val Asp Lys Lys Ser Lys 
    290                 295                 300                 


His Lys Thr Cys Val Lys Lys Lys Thr Leu Asn Pro Glu Phe Asn Glu 
305                 310                 315                 320 


Glu Phe Phe Tyr Glu Ile Glu Leu Ser Thr Leu Ala Thr Lys Thr Leu 
                325                 330                 335     


Glu Val Thr Val Trp Asp Tyr Asp Ile Gly Lys Ser Asn Asp Phe Ile 
            340                 345                 350         


Gly Gly Val Ser Leu Gly Pro Gly Ala Arg Gly Glu Ala Arg Lys His 
        355                 360                 365             


Trp Ser Asp Cys Leu Gln Gln Pro Asp Ala Ala Leu Glu Arg Trp His 
    370                 375                 380                 


Thr Leu Thr Ser Glu Leu Pro Pro Ala Ala Gly Ala Leu Ser Ser Ala 
385                 390                 395                 400 


<210>  3199
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOC2B__Homo_sapiens__NP_003576

<400>  3199

Met Thr Leu Arg Arg Arg Gly Glu Lys Ala Thr Ile Ser Ile Gln Glu 
1               5                   10                  15      


His Met Ala Ile Asp Val Cys Pro Gly Pro Ile Arg Pro Ile Lys Gln 
            20                  25                  30          


Ile Ser Asp Tyr Phe Pro Arg Phe Pro Arg Gly Leu Pro Pro Asp Ala 
        35                  40                  45              


Gly Pro Arg Ala Ala Ala Pro Pro Asp Ala Pro Ala Arg Pro Ala Val 
    50                  55                  60                  


Ala Gly Ala Gly Arg Arg Ser Pro Ser Asp Gly Ala Arg Glu Asp Asp 
65                  70                  75                  80  


Glu Asp Val Asp Gln Leu Phe Gly Ala Tyr Gly Ser Ser Pro Gly Pro 
                85                  90                  95      


Ser Pro Gly Pro Ser Pro Ala Arg Pro Pro Ala Lys Pro Pro Glu Asp 
            100                 105                 110         


Glu Pro Asp Ala Asp Gly Tyr Glu Ser Asp Asp Cys Thr Ala Leu Gly 
        115                 120                 125             


Thr Leu Asp Phe Ser Leu Leu Tyr Asp Gln Glu Asn Asn Ala Leu His 
    130                 135                 140                 


Cys Thr Ile Thr Lys Ala Lys Gly Leu Lys Pro Met Asp His Asn Gly 
145                 150                 155                 160 


Leu Ala Asp Pro Tyr Val Lys Leu His Leu Leu Pro Gly Ala Ser Lys 
                165                 170                 175     


Ala Asn Lys Leu Arg Thr Lys Thr Leu Arg Asn Thr Leu Asn Pro Thr 
            180                 185                 190         


Trp Asn Glu Thr Leu Thr Tyr Tyr Gly Ile Thr Asp Glu Asp Met Ile 
        195                 200                 205             


Arg Lys Thr Leu Arg Ile Ser Val Cys Asp Glu Asp Lys Phe Arg His 
    210                 215                 220                 


Asn Glu Phe Ile Gly Glu Thr Arg Val Pro Leu Lys Lys Leu Lys Pro 
225                 230                 235                 240 


Asn His Thr Lys Thr Phe Ser Ile Cys Leu Glu Lys Gln Leu Pro Val 
                245                 250                 255     


Asp Lys Thr Glu Asp Lys Ser Leu Glu Glu Arg Gly Arg Ile Leu Ile 
            260                 265                 270         


Ser Leu Lys Tyr Ser Ser Gln Lys Gln Gly Leu Leu Val Gly Ile Val 
        275                 280                 285             


Arg Cys Ala His Leu Ala Ala Met Asp Ala Asn Gly Tyr Ser Asp Pro 
    290                 295                 300                 


Tyr Val Lys Thr Tyr Leu Arg Pro Asp Val Asp Lys Lys Ser Lys His 
305                 310                 315                 320 


Lys Thr Ala Val Lys Lys Lys Thr Leu Asn Pro Glu Phe Asn Glu Glu 
                325                 330                 335     


Phe Cys Tyr Glu Ile Lys His Gly Asp Leu Ala Lys Lys Ser Leu Glu 
            340                 345                 350         


Val Thr Val Trp Asp Tyr Asp Ile Gly Lys Ser Asn Asp Phe Ile Gly 
        355                 360                 365             


Gly Val Val Leu Gly Ile His Ala Lys Gly Glu Arg Leu Lys His Trp 
    370                 375                 380                 


Phe Asp Cys Leu Lys Asn Lys Asp Lys Arg Ile Glu Arg Trp His Thr 
385                 390                 395                 400 


Leu Thr Ser Glu Leu Pro Gly Ala Val Leu Ser Asp 
                405                 410         


<210>  3200
<211>  2180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK10__Homo_sapiens__NP_001277192

<400>  3200

Met Ser Phe Arg Gly Lys Val Phe Lys Arg Glu Pro Ser Glu Phe Trp 
1               5                   10                  15      


Lys Lys Arg Arg Thr Val Arg Arg Val Asn Gln Glu Glu Ile His Arg 
            20                  25                  30          


Phe Ser Ser Gln Glu Lys Pro Arg Leu Leu Glu Pro Leu Asp Tyr Glu 
        35                  40                  45              


Thr Val Ile Glu Glu Leu Glu Lys Thr Tyr Arg Asn Asp Pro Leu Gln 
    50                  55                  60                  


Asp Leu Leu Phe Phe Pro Ser Asp Asp Phe Ser Ala Ala Thr Val Ser 
65                  70                  75                  80  


Trp Asp Ile Arg Thr Leu Tyr Ser Thr Val Pro Glu Asp Ala Glu His 
                85                  90                  95      


Lys Ala Glu Asn Leu Leu Val Lys Glu Ala Cys Lys Phe Tyr Ser Ser 
            100                 105                 110         


Gln Trp His Val Val Asn Tyr Lys Tyr Glu Gln Tyr Ser Gly Asp Ile 
        115                 120                 125             


Arg Gln Leu Pro Arg Ala Glu Tyr Lys Pro Glu Lys Leu Pro Ser His 
    130                 135                 140                 


Ser Phe Glu Ile Asp His Glu Asp Ala Asp Lys Asp Glu Asp Thr Thr 
145                 150                 155                 160 


Ser His Ser Ser Ser Lys Gly Gly Gly Gly Ala Gly Gly Thr Gly Val 
                165                 170                 175     


Phe Lys Ser Gly Trp Leu Tyr Lys Gly Asn Phe Asn Ser Thr Val Asn 
            180                 185                 190         


Asn Thr Val Thr Val Arg Ser Phe Lys Lys Arg Tyr Phe Gln Leu Thr 
        195                 200                 205             


Gln Leu Pro Asp Asn Ser Tyr Ile Met Asn Phe Tyr Lys Asp Glu Lys 
    210                 215                 220                 


Ile Ser Lys Glu Pro Lys Gly Cys Ile Phe Leu Asp Ser Cys Thr Gly 
225                 230                 235                 240 


Val Val Gln Asn Asn Arg Leu Arg Lys Tyr Ala Phe Glu Leu Lys Met 
                245                 250                 255     


Asn Asp Leu Thr Tyr Phe Val Leu Ala Ala Glu Thr Glu Ser Asp Met 
            260                 265                 270         


Asp Glu Trp Ile His Thr Leu Asn Arg Ile Leu Gln Ile Ser Pro Glu 
        275                 280                 285             


Gly Pro Leu Gln Gly Arg Arg Ser Thr Glu Leu Thr Asp Leu Gly Leu 
    290                 295                 300                 


Asp Ser Leu Asp Asn Ser Val Thr Cys Glu Cys Thr Pro Glu Glu Thr 
305                 310                 315                 320 


Asp Ser Ser Glu Asn Asn Leu His Ala Asp Phe Ala Lys Tyr Leu Thr 
                325                 330                 335     


Glu Thr Glu Asp Thr Val Lys Thr Thr Arg Asn Met Glu Arg Leu Asn 
            340                 345                 350         


Leu Phe Ser Leu Asp Pro Asp Ile Asp Thr Leu Lys Leu Gln Lys Lys 
        355                 360                 365             


Asp Leu Leu Glu Pro Glu Ser Val Ile Lys Pro Phe Glu Glu Lys Ala 
    370                 375                 380                 


Ala Lys Arg Ile Met Ile Ile Cys Lys Ala Leu Asn Ser Asn Leu Gln 
385                 390                 395                 400 


Gly Cys Val Thr Glu Asn Glu Asn Asp Pro Ile Thr Asn Ile Glu Pro 
                405                 410                 415     


Phe Phe Val Ser Val Ala Leu Tyr Asp Leu Arg Asp Ser Arg Lys Ile 
            420                 425                 430         


Ser Ala Asp Phe His Val Asp Leu Asn His Ala Ala Val Arg Gln Met 
        435                 440                 445             


Leu Leu Gly Ala Ser Val Ala Leu Glu Asn Gly Asn Ile Asp Thr Ile 
    450                 455                 460                 


Thr Pro Arg Gln Ser Glu Glu Pro His Ile Lys Gly Leu Pro Glu Glu 
465                 470                 475                 480 


Trp Leu Lys Phe Pro Lys Gln Ala Val Phe Ser Val Ser Asn Pro His 
                485                 490                 495     


Ser Glu Ile Val Leu Val Ala Lys Ile Glu Lys Val Leu Met Gly Asn 
            500                 505                 510         


Ile Ala Ser Gly Ala Glu Pro Tyr Ile Lys Asn Pro Asp Ser Asn Lys 
        515                 520                 525             


Tyr Ala Gln Lys Ile Leu Lys Ser Asn Arg Gln Phe Cys Ser Lys Leu 
    530                 535                 540                 


Gly Lys Tyr Arg Met Pro Phe Ala Trp Ala Val Arg Ser Val Phe Lys 
545                 550                 555                 560 


Asp Asn Gln Gly Asn Val Asp Arg Asp Ser Arg Phe Ser Pro Leu Phe 
                565                 570                 575     


Arg Gln Glu Ser Ser Lys Ile Ser Thr Glu Asp Leu Val Lys Leu Val 
            580                 585                 590         


Ser Asp Tyr Arg Arg Ala Asp Arg Ile Ser Lys Met Gln Thr Ile Pro 
        595                 600                 605             


Gly Ser Leu Asp Ile Ala Val Asp Asn Val Pro Leu Glu His Pro Asn 
    610                 615                 620                 


Cys Val Thr Ser Ser Phe Ile Pro Val Lys Pro Phe Asn Met Met Ala 
625                 630                 635                 640 


Gln Thr Glu Pro Thr Val Glu Val Glu Glu Phe Val Tyr Asp Ser Thr 
                645                 650                 655     


Lys Tyr Cys Arg Pro Tyr Arg Val Tyr Lys Asn Gln Ile Tyr Ile Tyr 
            660                 665                 670         


Pro Lys His Leu Lys Tyr Asp Ser Gln Lys Cys Phe Asn Lys Ala Arg 
        675                 680                 685             


Asn Ile Thr Val Cys Ile Glu Phe Lys Asn Ser Asp Glu Glu Ser Ala 
    690                 695                 700                 


Lys Pro Leu Lys Cys Ile Tyr Gly Lys Pro Gly Gly Pro Leu Phe Thr 
705                 710                 715                 720 


Ser Ala Ala Tyr Thr Ala Val Leu His His Ser Gln Asn Pro Asp Phe 
                725                 730                 735     


Ser Asp Glu Val Lys Ile Glu Leu Pro Thr Gln Leu His Glu Lys His 
            740                 745                 750         


His Ile Leu Phe Ser Phe Tyr His Val Thr Cys Asp Ile Asn Ala Lys 
        755                 760                 765             


Ala Asn Ala Lys Lys Lys Glu Ala Leu Glu Thr Ser Val Gly Tyr Ala 
    770                 775                 780                 


Trp Leu Pro Leu Met Lys His Asp Gln Ile Ala Ser Gln Glu Tyr Asn 
785                 790                 795                 800 


Ile Pro Ile Ala Thr Ser Leu Pro Pro Asn Tyr Leu Ser Phe Gln Asp 
                805                 810                 815     


Ser Ala Ser Gly Lys His Gly Gly Ser Asp Ile Lys Trp Val Asp Gly 
            820                 825                 830         


Gly Lys Pro Leu Phe Lys Val Ser Thr Phe Val Val Ser Thr Val Asn 
        835                 840                 845             


Thr Gln Asp Pro His Val Asn Ala Phe Phe Gln Glu Cys Gln Lys Arg 
    850                 855                 860                 


Glu Lys Asp Met Ser Gln Ser Pro Thr Ser Asn Phe Ile Arg Ser Cys 
865                 870                 875                 880 


Lys Asn Leu Leu Asn Val Glu Lys Ile His Ala Ile Met Ser Phe Leu 
                885                 890                 895     


Pro Ile Ile Leu Asn Gln Leu Phe Lys Val Leu Val Gln Asn Glu Glu 
            900                 905                 910         


Asp Glu Ile Thr Thr Thr Val Thr Arg Val Leu Thr Asp Ile Val Ala 
        915                 920                 925             


Lys Cys His Glu Glu Gln Leu Asp His Ser Val Gln Ser Tyr Ile Lys 
    930                 935                 940                 


Phe Val Phe Lys Thr Arg Ala Cys Lys Glu Arg Thr Val His Glu Glu 
945                 950                 955                 960 


Leu Ala Lys Asn Val Thr Gly Leu Leu Lys Ser Asn Asp Ser Thr Thr 
                965                 970                 975     


Val Lys His Val Leu Lys His Ser Trp Phe Phe Phe Ala Ile Ile Leu 
            980                 985                 990         


Lys Ser Met Ala Gln His Leu Ile  Asp Thr Asn Lys Ile  Gln Leu Pro 
        995                 1000                 1005             


Arg Pro  Gln Arg Phe Pro Glu  Ser Tyr Gln Asn Glu  Leu Asp Asn 
    1010                 1015                 1020             


Leu Val  Met Val Leu Ser Asp  His Val Ile Trp Lys  Tyr Lys Asp 
    1025                 1030                 1035             


Ala Leu  Glu Glu Thr Arg Arg  Ala Asn His Ser Val  Ala Arg Phe 
    1040                 1045                 1050             


Leu Lys  Arg Cys Phe Thr Phe  Met Asp Arg Gly Tyr  Val Phe Lys 
    1055                 1060                 1065             


Met Val  Asn Asn Tyr Ile Ser  Met Phe Ser Ser Gly  Asp Leu Lys 
    1070                 1075                 1080             


Thr Leu  Cys Gln Tyr Lys Phe  Asp Phe Leu Gln Glu  Val Cys Gln 
    1085                 1090                 1095             


His Glu  His Phe Ile Pro Leu  Cys Leu Pro Ile Arg  Ser Ala Asn 
    1100                 1105                 1110             


Ile Pro  Asp Pro Leu Thr Pro  Ser Glu Ser Thr Gln  Glu Leu His 
    1115                 1120                 1125             


Ala Ser  Asp Met Pro Glu Tyr  Ser Val Thr Asn Glu  Phe Cys Arg 
    1130                 1135                 1140             


Lys His  Phe Leu Ile Gly Ile  Leu Leu Arg Glu Val  Gly Phe Ala 
    1145                 1150                 1155             


Leu Gln  Glu Asp Gln Asp Val  Arg His Leu Ala Leu  Ala Val Leu 
    1160                 1165                 1170             


Lys Asn  Leu Met Ala Lys His  Ser Phe Asp Asp Arg  Tyr Arg Glu 
    1175                 1180                 1185             


Pro Arg  Lys Gln Ala Gln Ile  Ala Ser Leu Tyr Met  Pro Leu Tyr 
    1190                 1195                 1200             


Gly Met  Leu Leu Asp Asn Met  Pro Arg Ile Tyr Leu  Lys Asp Leu 
    1205                 1210                 1215             


Tyr Pro  Phe Thr Val Asn Thr  Ser Asn Gln Gly Ser  Arg Asp Asp 
    1220                 1225                 1230             


Leu Ser  Thr Asn Gly Gly Phe  Gln Ser Gln Thr Ala  Ile Lys His 
    1235                 1240                 1245             


Ala Asn  Ser Val Asp Thr Ser  Phe Ser Lys Asp Val  Leu Asn Ser 
    1250                 1255                 1260             


Ile Ala  Ala Phe Ser Ser Ile  Ala Ile Ser Thr Val  Asn His Ala 
    1265                 1270                 1275             


Asp Ser  Arg Ala Ser Leu Ala  Ser Leu Asp Ser Asn  Pro Ser Thr 
    1280                 1285                 1290             


Asn Glu  Lys Ser Ser Glu Lys  Thr Asp Asn Cys Glu  Lys Ile Pro 
    1295                 1300                 1305             


Arg Pro  Leu Ser Leu Ile Gly  Ser Thr Leu Arg Phe  Asp Lys Leu 
    1310                 1315                 1320             


Asp Gln  Ala Glu Thr Arg Ser  Leu Leu Met Cys Phe  Leu His Ile 
    1325                 1330                 1335             


Met Lys  Thr Ile Ser Tyr Glu  Thr Leu Ile Ala Tyr  Trp Gln Arg 
    1340                 1345                 1350             


Ala Pro  Ser Pro Glu Val Ser  Asp Phe Phe Ser Ile  Leu Asp Val 
    1355                 1360                 1365             


Cys Leu  Gln Asn Phe Arg Tyr  Leu Gly Lys Arg Asn  Ile Ile Arg 
    1370                 1375                 1380             


Lys Ile  Ala Ala Ala Phe Lys  Phe Val Gln Ser Thr  Gln Asn Asn 
    1385                 1390                 1395             


Gly Thr  Leu Lys Gly Ser Asn  Pro Ser Cys Gln Thr  Ser Gly Leu 
    1400                 1405                 1410             


Leu Ser  Gln Trp Met His Ser  Thr Ser Ser His Glu  Gly His Lys 
    1415                 1420                 1425             


Gln His  Arg Ser Gln Thr Leu  Pro Ile Ile Arg Gly  Lys Asn Ala 
    1430                 1435                 1440             


Leu Ser  Asn Pro Lys Leu Leu  Gln Met Leu Asp Asn  Thr Met Thr 
    1445                 1450                 1455             


Ser Asn  Ser Asn Glu Ile Asp  Ile Val His His Val  Asp Thr Glu 
    1460                 1465                 1470             


Ala Asn  Ile Ala Thr Glu Val  Cys Leu Thr Ile Leu  Asp Leu Leu 
    1475                 1480                 1485             


Ser Leu  Phe Thr Gln Thr His  Gln Arg Gln Leu Gln  Gln Cys Asp 
    1490                 1495                 1500             


Cys Gln  Asn Ser Leu Met Lys  Arg Val Phe Asp Thr  Tyr Met Leu 
    1505                 1510                 1515             


Phe Phe  Gln Val Asn Gln Ser  Ala Thr Ala Leu Lys  His Val Phe 
    1520                 1525                 1530             


Ala Ser  Leu Arg Leu Phe Val  Cys Lys Phe Pro Ser  Ala Phe Phe 
    1535                 1540                 1545             


Gln Gly  Pro Ala Asp Leu Cys  Gly Ser Phe Cys Tyr  Glu Val Leu 
    1550                 1555                 1560             


Lys Cys  Cys Asn His Arg Ser  Arg Ser Thr Gln Thr  Glu Ala Ser 
    1565                 1570                 1575             


Ala Leu  Leu Tyr Phe Phe Met  Arg Lys Asn Phe Glu  Phe Asn Lys 
    1580                 1585                 1590             


Gln Lys  Ser Ile Val Arg Ser  His Leu Gln Leu Ile  Lys Ala Val 
    1595                 1600                 1605             


Ser Gln  Leu Ile Ala Asp Ala  Gly Ile Gly Gly Ser  Arg Phe Gln 
    1610                 1615                 1620             


His Ser  Leu Ala Ile Thr Asn  Asn Phe Ala Asn Gly  Asp Lys Gln 
    1625                 1630                 1635             


Met Lys  Asn Ser Asn Phe Pro  Ala Glu Val Lys Asp  Leu Thr Lys 
    1640                 1645                 1650             


Arg Ile  Arg Thr Val Leu Met  Ala Thr Ala Gln Met  Lys Glu His 
    1655                 1660                 1665             


Glu Lys  Asp Pro Glu Met Leu  Val Asp Leu Gln Tyr  Ser Leu Ala 
    1670                 1675                 1680             


Asn Ser  Tyr Ala Ser Thr Pro  Glu Leu Arg Arg Thr  Trp Leu Glu 
    1685                 1690                 1695             


Ser Met  Ala Lys Ile His Ala  Arg Asn Gly Asp Leu  Ser Glu Ala 
    1700                 1705                 1710             


Ala Met  Cys Tyr Ile His Ile  Ala Ala Leu Ile Ala  Glu Tyr Leu 
    1715                 1720                 1725             


Lys Arg  Lys Gly Tyr Trp Lys  Val Glu Lys Ile Cys  Thr Ala Ser 
    1730                 1735                 1740             


Leu Leu  Ser Glu Asp Thr His  Pro Cys Asp Ser Asn  Ser Leu Leu 
    1745                 1750                 1755             


Thr Thr  Pro Ser Gly Gly Ser  Met Phe Ser Met Gly  Trp Pro Ala 
    1760                 1765                 1770             


Phe Leu  Ser Ile Thr Pro Asn  Ile Lys Glu Glu Gly  Ala Met Lys 
    1775                 1780                 1785             


Glu Asp  Ser Gly Met Gln Asp  Thr Pro Tyr Asn Glu  Asn Ile Leu 
    1790                 1795                 1800             


Val Glu  Gln Leu Tyr Met Cys  Val Glu Phe Leu Trp  Lys Ser Glu 
    1805                 1810                 1815             


Arg Tyr  Glu Leu Ile Ala Asp  Val Asn Lys Pro Ile  Ile Ala Val 
    1820                 1825                 1830             


Phe Glu  Lys Gln Arg Asp Phe  Lys Lys Leu Ser Asp  Leu Tyr Tyr 
    1835                 1840                 1845             


Asp Ile  His Arg Ser Tyr Leu  Lys Val Ala Glu Val  Val Asn Ser 
    1850                 1855                 1860             


Glu Lys  Arg Leu Phe Gly Arg  Tyr Tyr Arg Val Ala  Phe Tyr Gly 
    1865                 1870                 1875             


Gln Gly  Phe Phe Glu Glu Glu  Glu Gly Lys Glu Tyr  Ile Tyr Lys 
    1880                 1885                 1890             


Glu Pro  Lys Leu Thr Gly Leu  Ser Glu Ile Ser Gln  Arg Leu Leu 
    1895                 1900                 1905             


Lys Leu  Tyr Ala Asp Lys Phe  Gly Ala Asp Asn Val  Lys Ile Ile 
    1910                 1915                 1920             


Gln Asp  Ser Asn Lys Val Asn  Pro Lys Asp Leu Asp  Pro Lys Tyr 
    1925                 1930                 1935             


Ala Tyr  Ile Gln Val Thr Tyr  Val Thr Pro Phe Phe  Glu Glu Lys 
    1940                 1945                 1950             


Glu Ile  Glu Asp Arg Lys Thr  Asp Phe Glu Met His  His Asn Ile 
    1955                 1960                 1965             


Asn Arg  Phe Val Phe Glu Thr  Pro Phe Thr Leu Ser  Gly Lys Lys 
    1970                 1975                 1980             


His Gly  Gly Val Ala Glu Gln  Cys Lys Arg Arg Thr  Ile Leu Thr 
    1985                 1990                 1995             


Thr Ser  His Leu Phe Pro Tyr  Val Lys Lys Arg Ile  Gln Val Ile 
    2000                 2005                 2010             


Ser Gln  Ser Ser Thr Glu Leu  Asn Pro Ile Glu Val  Ala Ile Asp 
    2015                 2020                 2025             


Glu Met  Ser Lys Lys Val Ser  Glu Leu Asn Gln Leu  Cys Thr Met 
    2030                 2035                 2040             


Glu Glu  Val Asp Met Ile Arg  Leu Gln Leu Lys Leu  Gln Gly Ser 
    2045                 2050                 2055             


Val Ser  Val Lys Val Asn Ala  Gly Pro Met Ala Tyr  Ala Arg Ala 
    2060                 2065                 2070             


Phe Leu  Glu Glu Thr Asn Ala  Lys Lys Tyr Pro Asp  Asn Gln Val 
    2075                 2080                 2085             


Lys Leu  Leu Lys Glu Ile Phe  Arg Gln Phe Ala Asp  Ala Cys Gly 
    2090                 2095                 2100             


Gln Ala  Leu Asp Val Asn Glu  Arg Leu Ile Lys Glu  Asp Gln Leu 
    2105                 2110                 2115             


Glu Tyr  Gln Glu Glu Leu Arg  Ser His Tyr Lys Asp  Met Leu Ser 
    2120                 2125                 2130             


Glu Leu  Ser Thr Val Met Asn  Glu Gln Ile Thr Gly  Arg Asp Asp 
    2135                 2140                 2145             


Leu Ser  Lys Arg Gly Val Asp  Gln Thr Cys Thr Arg  Val Ile Ser 
    2150                 2155                 2160             


Lys Ala  Thr Pro Ala Leu Pro  Thr Val Ser Ile Ser  Ser Ser Ala 
    2165                 2170                 2175             


Glu Val  
    2180 


<210>  3201
<211>  2073
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK11__Homo_sapiens__NP_653259

<400>  3201

Met Ala Glu Val Arg Lys Phe Thr Lys Arg Leu Ser Lys Pro Gly Thr 
1               5                   10                  15      


Ala Ala Glu Leu Arg Gln Ser Val Ser Glu Ala Val Arg Gly Ser Val 
            20                  25                  30          


Val Leu Glu Lys Ala Lys Val Val Glu Pro Leu Asp Tyr Glu Asn Val 
        35                  40                  45              


Ile Ala Gln Arg Lys Thr Gln Ile Tyr Ser Asp Pro Leu Arg Asp Leu 
    50                  55                  60                  


Leu Met Phe Pro Met Glu Asp Ile Ser Ile Ser Val Ile Gly Arg Gln 
65                  70                  75                  80  


Arg Arg Thr Val Gln Ser Thr Val Pro Glu Asp Ala Glu Lys Arg Ala 
                85                  90                  95      


Gln Ser Leu Phe Val Lys Glu Cys Ile Lys Thr Tyr Ser Thr Asp Trp 
            100                 105                 110         


His Val Val Asn Tyr Lys Tyr Glu Asp Phe Ser Gly Asp Phe Arg Met 
        115                 120                 125             


Leu Pro Cys Lys Ser Leu Arg Pro Glu Lys Ile Pro Asn His Val Phe 
    130                 135                 140                 


Glu Ile Asp Glu Asp Cys Glu Lys Asp Glu Asp Ser Ser Ser Leu Cys 
145                 150                 155                 160 


Ser Gln Lys Gly Gly Val Ile Lys Gln Gly Trp Leu His Lys Ala Asn 
                165                 170                 175     


Val Asn Ser Thr Ile Thr Val Thr Met Lys Val Phe Lys Arg Arg Tyr 
            180                 185                 190         


Phe Tyr Leu Thr Gln Leu Pro Asp Gly Ser Tyr Ile Leu Asn Ser Tyr 
        195                 200                 205             


Lys Asp Glu Lys Asn Ser Lys Glu Ser Lys Gly Cys Ile Tyr Leu Asp 
    210                 215                 220                 


Ala Cys Ile Asp Val Val Gln Cys Pro Lys Met Arg Arg His Ala Phe 
225                 230                 235                 240 


Glu Leu Lys Met Leu Asp Lys Tyr Ser His Tyr Leu Ala Ala Glu Thr 
                245                 250                 255     


Glu Gln Glu Met Glu Glu Trp Leu Ile Thr Leu Lys Lys Ile Ile Gln 
            260                 265                 270         


Ile Asn Thr Asp Ser Leu Val Gln Glu Lys Lys Glu Thr Val Glu Thr 
        275                 280                 285             


Ala Gln Asp Asp Glu Thr Ser Ser Gln Gly Lys Ala Glu Asn Ile Met 
    290                 295                 300                 


Ala Ser Leu Glu Arg Ser Met His Pro Glu Leu Met Lys Tyr Gly Arg 
305                 310                 315                 320 


Glu Thr Glu Gln Leu Asn Lys Leu Ser Arg Gly Asp Gly Arg Gln Asn 
                325                 330                 335     


Leu Phe Ser Phe Asp Ser Glu Val Gln Arg Leu Asp Phe Ser Gly Ile 
            340                 345                 350         


Glu Pro Asp Ile Lys Pro Phe Glu Glu Lys Cys Asn Lys Arg Phe Leu 
        355                 360                 365             


Val Asn Cys His Asp Leu Thr Phe Asn Ile Leu Gly Gln Ile Gly Asp 
    370                 375                 380                 


Asn Ala Lys Gly Pro Pro Thr Asn Val Glu Pro Phe Phe Ile Asn Leu 
385                 390                 395                 400 


Ala Leu Phe Asp Val Lys Asn Asn Cys Lys Ile Ser Ala Asp Phe His 
                405                 410                 415     


Val Asp Leu Asn Pro Pro Ser Val Arg Glu Met Leu Trp Gly Ser Ser 
            420                 425                 430         


Thr Gln Leu Ala Ser Asp Gly Ser Pro Lys Gly Ser Ser Pro Glu Ser 
        435                 440                 445             


Tyr Ile His Gly Ile Ala Glu Ser Gln Leu Arg Tyr Ile Gln Gln Gly 
    450                 455                 460                 


Ile Phe Ser Val Thr Asn Pro His Pro Glu Ile Phe Leu Val Ala Arg 
465                 470                 475                 480 


Ile Glu Lys Val Leu Gln Gly Asn Ile Thr His Cys Ala Glu Pro Tyr 
                485                 490                 495     


Ile Lys Asn Ser Asp Pro Val Lys Thr Ala Gln Lys Val His Arg Thr 
            500                 505                 510         


Ala Lys Gln Val Cys Ser Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala 
        515                 520                 525             


Trp Ala Ala Arg Pro Ile Phe Lys Asp Thr Gln Gly Ser Leu Asp Leu 
    530                 535                 540                 


Asp Gly Arg Phe Ser Pro Leu Tyr Lys Gln Asp Ser Ser Lys Leu Ser 
545                 550                 555                 560 


Ser Glu Asp Ile Leu Lys Leu Leu Ser Glu Tyr Lys Lys Pro Glu Lys 
                565                 570                 575     


Thr Lys Leu Gln Ile Ile Pro Gly Gln Leu Asn Ile Thr Val Glu Cys 
            580                 585                 590         


Val Pro Val Asp Leu Ser Asn Cys Ile Thr Ser Ser Tyr Val Pro Leu 
        595                 600                 605             


Lys Pro Phe Glu Lys Asn Cys Gln Asn Ile Thr Val Glu Val Glu Glu 
    610                 615                 620                 


Phe Val Pro Glu Met Thr Lys Tyr Cys Tyr Pro Phe Thr Ile Tyr Lys 
625                 630                 635                 640 


Asn His Leu Tyr Val Tyr Pro Leu Gln Leu Lys Tyr Asp Ser Gln Lys 
                645                 650                 655     


Thr Phe Ala Lys Ala Arg Asn Ile Ala Val Cys Val Glu Phe Arg Asp 
            660                 665                 670         


Ser Asp Glu Ser Asp Ala Ser Ala Leu Lys Cys Ile Tyr Gly Lys Pro 
        675                 680                 685             


Ala Gly Ser Val Phe Thr Thr Asn Ala Tyr Ala Val Val Ser His His 
    690                 695                 700                 


Asn Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Ile 
705                 710                 715                 720 


His Leu His Gln Lys His His Leu Leu Phe Thr Phe Tyr His Val Ser 
                725                 730                 735     


Cys Glu Ile Asn Thr Lys Gly Thr Thr Lys Lys Gln Asp Thr Val Glu 
            740                 745                 750         


Thr Pro Val Gly Phe Ala Trp Val Pro Leu Leu Lys Asp Gly Arg Ile 
        755                 760                 765             


Ile Thr Phe Glu Gln Gln Leu Pro Val Ser Ala Asn Leu Pro Pro Gly 
    770                 775                 780                 


Tyr Leu Asn Leu Asn Asp Ala Glu Ser Arg Arg Gln Cys Asn Val Asp 
785                 790                 795                 800 


Ile Lys Trp Val Asp Gly Ala Lys Pro Leu Leu Lys Ile Lys Ser His 
                805                 810                 815     


Leu Glu Ser Thr Ile Tyr Thr Gln Asp Leu His Val His Lys Phe Phe 
            820                 825                 830         


His His Cys Gln Leu Ile Gln Ser Gly Ser Lys Glu Val Pro Gly Glu 
        835                 840                 845             


Leu Ile Lys Tyr Leu Lys Cys Leu His Ala Met Glu Ile Gln Val Met 
    850                 855                 860                 


Ile Gln Phe Leu Pro Val Ile Leu Met Gln Leu Phe Arg Val Leu Thr 
865                 870                 875                 880 


Asn Met Thr His Glu Asp Asp Val Pro Ile Asn Cys Thr Met Val Leu 
                885                 890                 895     


Leu His Ile Val Ser Lys Cys His Glu Glu Gly Leu Asp Ser Tyr Leu 
            900                 905                 910         


Arg Ser Phe Ile Lys Tyr Ser Phe Arg Pro Glu Lys Pro Ser Ala Pro 
        915                 920                 925             


Gln Ala Gln Leu Ile His Glu Thr Leu Ala Thr Thr Met Ile Ala Ile 
    930                 935                 940                 


Leu Lys Gln Ser Ala Asp Phe Leu Ser Ile Asn Lys Leu Leu Lys Tyr 
945                 950                 955                 960 


Ser Trp Phe Phe Phe Glu Ile Ile Ala Lys Ser Met Ala Thr Tyr Leu 
                965                 970                 975     


Leu Glu Glu Asn Lys Ile Lys Leu Pro Arg Gly Gln Arg Phe Pro Glu 
            980                 985                 990         


Thr Tyr His His Val Leu His Ser  Leu Leu Leu Ala Ile  Ile Pro His 
        995                 1000                 1005             


Val Thr  Ile Arg Tyr Ala Glu  Ile Pro Asp Glu Ser  Arg Asn Val 
    1010                 1015                 1020             


Asn Tyr  Ser Leu Ala Ser Phe  Leu Lys Arg Cys Leu  Thr Leu Met 
    1025                 1030                 1035             


Asp Arg  Gly Phe Ile Phe Asn  Leu Ile Asn Asp Tyr  Ile Ser Gly 
    1040                 1045                 1050             


Phe Ser  Pro Lys Asp Pro Lys  Val Leu Ala Glu Tyr  Lys Phe Glu 
    1055                 1060                 1065             


Phe Leu  Gln Thr Ile Cys Asn  His Glu His Tyr Ile  Pro Leu Asn 
    1070                 1075                 1080             


Leu Pro  Met Ala Phe Ala Lys  Pro Lys Leu Gln Arg  Val Gln Asp 
    1085                 1090                 1095             


Ser Asn  Leu Glu Tyr Ser Leu  Ser Asp Glu Tyr Cys  Lys His His 
    1100                 1105                 1110             


Phe Leu  Val Gly Leu Leu Leu  Arg Glu Thr Ser Ile  Ala Leu Gln 
    1115                 1120                 1125             


Asp Asn  Tyr Glu Ile Arg Tyr  Thr Ala Ile Ser Val  Ile Lys Asn 
    1130                 1135                 1140             


Leu Leu  Ile Lys His Ala Phe  Asp Thr Arg Tyr Gln  His Lys Asn 
    1145                 1150                 1155             


Gln Gln  Ala Lys Ile Ala Gln  Leu Tyr Leu Pro Phe  Val Gly Leu 
    1160                 1165                 1170             


Leu Leu  Glu Asn Ile Gln Arg  Leu Ala Gly Arg Asp  Thr Leu Tyr 
    1175                 1180                 1185             


Ser Cys  Ala Ala Met Pro Asn  Ser Ala Ser Arg Asp  Glu Phe Pro 
    1190                 1195                 1200             


Cys Gly  Phe Thr Ser Pro Ala  Asn Arg Gly Ser Leu  Ser Thr Asp 
    1205                 1210                 1215             


Lys Asp  Thr Ala Tyr Gly Ser  Phe Gln Asn Gly His  Gly Ile Lys 
    1220                 1225                 1230             


Arg Glu  Asp Ser Arg Gly Ser  Leu Ile Pro Glu Gly  Ala Thr Gly 
    1235                 1240                 1245             


Phe Pro  Asp Gln Gly Asn Thr  Gly Glu Asn Thr Arg  Gln Ser Ser 
    1250                 1255                 1260             


Thr Arg  Ser Ser Val Ser Gln  Tyr Asn Arg Leu Asp  Gln Tyr Glu 
    1265                 1270                 1275             


Ile Arg  Ser Leu Leu Met Cys  Tyr Leu Tyr Ile Val  Lys Met Ile 
    1280                 1285                 1290             


Ser Glu  Asp Thr Leu Leu Thr  Tyr Trp Asn Lys Val  Ser Pro Gln 
    1295                 1300                 1305             


Glu Leu  Ile Asn Ile Leu Ile  Leu Leu Glu Val Cys  Leu Phe His 
    1310                 1315                 1320             


Phe Arg  Tyr Met Gly Lys Arg  Asn Ile Ala Arg Val  His Asp Ala 
    1325                 1330                 1335             


Trp Leu  Ser Lys His Phe Gly  Ile Asp Arg Lys Ser  Gln Thr Met 
    1340                 1345                 1350             


Pro Ala  Leu Arg Asn Arg Ser  Gly Val Met Gln Ala  Arg Leu Gln 
    1355                 1360                 1365             


His Leu  Ser Ser Leu Glu Ser  Ser Phe Thr Leu Asn  His Ser Ser 
    1370                 1375                 1380             


Thr Thr  Thr Glu Ala Asp Ile  Phe His Gln Ala Leu  Leu Glu Gly 
    1385                 1390                 1395             


Asn Thr  Ala Thr Glu Val Ser  Leu Thr Val Leu Asp  Thr Ile Ser 
    1400                 1405                 1410             


Phe Phe  Thr Gln Cys Phe Lys  Thr Gln Leu Leu Asn  Asn Asp Gly 
    1415                 1420                 1425             


His Asn  Pro Leu Met Lys Lys  Val Phe Asp Ile His  Leu Ala Phe 
    1430                 1435                 1440             


Leu Lys  Asn Gly Gln Ser Glu  Val Ser Leu Lys His  Val Phe Ala 
    1445                 1450                 1455             


Ser Leu  Arg Ala Phe Ile Ser  Lys Phe Pro Ser Ala  Phe Phe Lys 
    1460                 1465                 1470             


Gly Arg  Val Asn Met Cys Ala  Ala Phe Cys Tyr Glu  Val Leu Lys 
    1475                 1480                 1485             


Cys Cys  Thr Ser Lys Ile Ser  Ser Thr Arg Asn Glu  Ala Ser Ala 
    1490                 1495                 1500             


Leu Leu  Tyr Leu Leu Met Arg  Asn Asn Phe Glu Tyr  Thr Lys Arg 
    1505                 1510                 1515             


Lys Thr  Phe Leu Arg Thr His  Leu Gln Ile Ile Ile  Ala Val Ser 
    1520                 1525                 1530             


Gln Leu  Ile Ala Asp Val Ala  Leu Ser Gly Gly Ser  Arg Phe Gln 
    1535                 1540                 1545             


Glu Ser  Leu Phe Ile Ile Asn  Asn Phe Ala Asn Ser  Asp Arg Pro 
    1550                 1555                 1560             


Met Lys  Ala Thr Ala Phe Pro  Ala Glu Val Lys Asp  Leu Thr Lys 
    1565                 1570                 1575             


Arg Ile  Arg Thr Val Leu Met  Ala Thr Ala Gln Met  Lys Glu His 
    1580                 1585                 1590             


Glu Lys  Asp Pro Glu Met Leu  Ile Asp Leu Gln Tyr  Ser Leu Ala 
    1595                 1600                 1605             


Lys Ser  Tyr Ala Ser Thr Pro  Glu Leu Arg Lys Thr  Trp Leu Asp 
    1610                 1615                 1620             


Ser Met  Ala Lys Ile His Val  Lys Asn Gly Asp Phe  Ser Glu Ala 
    1625                 1630                 1635             


Ala Met  Cys Tyr Val His Val  Ala Ala Leu Val Ala  Glu Phe Leu 
    1640                 1645                 1650             


His Arg  Lys Lys Leu Phe Pro  Asn Gly Cys Ser Ala  Phe Lys Lys 
    1655                 1660                 1665             


Ile Thr  Pro Asn Ile Asp Glu  Glu Gly Ala Met Lys  Glu Asp Ala 
    1670                 1675                 1680             


Gly Met  Met Asp Val His Tyr  Ser Glu Glu Val Leu  Leu Glu Leu 
    1685                 1690                 1695             


Leu Glu  Gln Cys Val Asp Gly  Leu Trp Lys Ala Glu  Arg Tyr Glu 
    1700                 1705                 1710             


Ile Ile  Ser Glu Ile Ser Lys  Leu Ile Val Pro Ile  Tyr Glu Lys 
    1715                 1720                 1725             


Arg Arg  Glu Phe Glu Lys Leu  Thr Gln Val Tyr Arg  Thr Leu His 
    1730                 1735                 1740             


Gly Ala  Tyr Thr Lys Ile Leu  Glu Val Met His Thr  Lys Lys Arg 
    1745                 1750                 1755             


Leu Leu  Gly Thr Phe Phe Arg  Val Ala Phe Tyr Gly  Gln Ser Phe 
    1760                 1765                 1770             


Phe Glu  Glu Glu Asp Gly Lys  Glu Tyr Ile Tyr Lys  Glu Pro Lys 
    1775                 1780                 1785             


Leu Thr  Gly Leu Ser Glu Ile  Ser Leu Arg Leu Val  Lys Leu Tyr 
    1790                 1795                 1800             


Gly Glu  Lys Phe Gly Thr Glu  Asn Val Lys Ile Ile  Gln Asp Ser 
    1805                 1810                 1815             


Asp Lys  Val Asn Ala Lys Glu  Leu Asp Pro Lys Tyr  Ala His Ile 
    1820                 1825                 1830             


Gln Val  Thr Tyr Val Lys Pro  Tyr Phe Asp Asp Lys  Glu Leu Thr 
    1835                 1840                 1845             


Glu Arg  Lys Thr Glu Phe Glu  Arg Asn His Asn Ile  Ser Arg Phe 
    1850                 1855                 1860             


Val Phe  Glu Ala Pro Tyr Thr  Leu Ser Gly Lys Lys  Gln Gly Cys 
    1865                 1870                 1875             


Ile Glu  Glu Gln Cys Lys Arg  Arg Thr Ile Leu Thr  Thr Ser Asn 
    1880                 1885                 1890             


Ser Phe  Pro Tyr Val Lys Lys  Arg Ile Pro Ile Asn  Cys Glu Gln 
    1895                 1900                 1905             


Gln Ile  Asn Leu Lys Pro Ile  Asp Val Ala Thr Asp  Glu Ile Lys 
    1910                 1915                 1920             


Asp Lys  Thr Ala Glu Leu Gln  Lys Leu Cys Ser Ser  Thr Asp Val 
    1925                 1930                 1935             


Asp Met  Ile Gln Leu Gln Leu  Lys Leu Gln Gly Cys  Val Ser Val 
    1940                 1945                 1950             


Gln Val  Asn Ala Gly Pro Leu  Ala Tyr Ala Arg Ala  Phe Leu Asn 
    1955                 1960                 1965             


Asp Ser  Gln Ala Ser Lys Tyr  Pro Pro Lys Lys Val  Ser Glu Leu 
    1970                 1975                 1980             


Lys Asp  Met Phe Arg Lys Phe  Ile Gln Ala Cys Ser  Ile Ala Leu 
    1985                 1990                 1995             


Glu Leu  Asn Glu Arg Leu Ile  Lys Glu Asp Gln Val  Glu Tyr His 
    2000                 2005                 2010             


Glu Gly  Leu Lys Ser Asn Phe  Arg Asp Met Val Lys  Glu Leu Ser 
    2015                 2020                 2025             


Asp Ile  Ile His Glu Gln Ile  Leu Gln Glu Asp Thr  Met His Ser 
    2030                 2035                 2040             


Pro Trp  Met Ser Asn Thr Leu  His Val Phe Cys Ala  Ile Ser Gly 
    2045                 2050                 2055             


Thr Ser  Ser Asp Arg Gly Tyr  Gly Ser Pro Arg Tyr  Ala Glu Val 
    2060                 2065                 2070             


<210>  3202
<211>  1865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK1__Homo_sapiens__NP_001371

<400>  3202

Met Thr Arg Trp Val Pro Thr Lys Arg Glu Glu Lys Tyr Gly Val Ala 
1               5                   10                  15      


Phe Tyr Asn Tyr Asp Ala Arg Gly Ala Asp Glu Leu Ser Leu Gln Ile 
            20                  25                  30          


Gly Asp Thr Val His Ile Leu Glu Thr Tyr Glu Gly Trp Tyr Arg Gly 
        35                  40                  45              


Tyr Thr Leu Arg Lys Lys Ser Lys Lys Gly Ile Phe Pro Ala Ser Tyr 
    50                  55                  60                  


Ile His Leu Lys Glu Ala Ile Val Glu Gly Lys Gly Gln His Glu Thr 
65                  70                  75                  80  


Val Ile Pro Gly Asp Leu Pro Leu Ile Gln Glu Val Thr Thr Thr Leu 
                85                  90                  95      


Arg Glu Trp Ser Thr Ile Trp Arg Gln Leu Tyr Val Gln Asp Asn Arg 
            100                 105                 110         


Glu Met Phe Arg Ser Val Arg His Met Ile Tyr Asp Leu Ile Glu Trp 
        115                 120                 125             


Arg Ser Gln Ile Leu Ser Gly Thr Leu Pro Gln Asp Glu Leu Lys Glu 
    130                 135                 140                 


Leu Lys Lys Lys Val Thr Ala Lys Ile Asp Tyr Gly Asn Arg Ile Leu 
145                 150                 155                 160 


Asp Leu Asp Leu Val Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro 
                165                 170                 175     


Glu Leu Thr Ser Thr Ile Ser Leu Phe Arg Ala His Glu Ile Ala Ser 
            180                 185                 190         


Lys Gln Val Glu Glu Arg Leu Gln Glu Glu Lys Ser Gln Lys Gln Asn 
        195                 200                 205             


Ile Asp Ile Asn Arg Gln Ala Lys Phe Ala Ala Thr Pro Ser Leu Ala 
    210                 215                 220                 


Leu Phe Val Asn Leu Lys Asn Val Val Cys Lys Ile Gly Glu Asp Ala 
225                 230                 235                 240 


Glu Val Leu Met Ser Leu Tyr Asp Pro Val Glu Ser Lys Phe Ile Ser 
                245                 250                 255     


Glu Asn Tyr Leu Val Arg Trp Ser Ser Ser Gly Leu Pro Lys Asp Ile 
            260                 265                 270         


Asp Arg Leu His Asn Leu Arg Ala Val Phe Thr Asp Leu Gly Ser Lys 
        275                 280                 285             


Asp Leu Lys Arg Glu Lys Ile Ser Phe Val Cys Gln Ile Val Arg Val 
    290                 295                 300                 


Gly Arg Met Glu Leu Arg Asp Asn Asn Thr Arg Lys Leu Thr Ser Gly 
305                 310                 315                 320 


Leu Arg Arg Pro Phe Gly Val Ala Val Met Asp Val Thr Asp Ile Ile 
                325                 330                 335     


Asn Gly Lys Val Asp Asp Glu Asp Lys Gln His Phe Ile Pro Phe Gln 
            340                 345                 350         


Pro Val Ala Gly Glu Asn Asp Phe Leu Gln Thr Val Ile Asn Lys Val 
        355                 360                 365             


Ile Ala Ala Lys Glu Val Asn His Lys Gly Gln Gly Leu Trp Val Thr 
    370                 375                 380                 


Leu Lys Leu Leu Pro Gly Asp Ile His Gln Ile Arg Lys Glu Phe Pro 
385                 390                 395                 400 


His Leu Val Asp Arg Thr Thr Ala Val Ala Arg Lys Thr Gly Phe Pro 
                405                 410                 415     


Glu Ile Ile Met Pro Gly Asp Val Arg Asn Asp Ile Tyr Val Thr Leu 
            420                 425                 430         


Val Gln Gly Asp Phe Asp Lys Gly Ser Lys Thr Thr Ala Lys Asn Val 
        435                 440                 445             


Glu Val Thr Val Ser Val Tyr Asp Glu Asp Gly Lys Arg Leu Glu His 
    450                 455                 460                 


Val Ile Phe Pro Gly Ala Gly Asp Glu Ala Ile Ser Glu Tyr Lys Ser 
465                 470                 475                 480 


Val Ile Tyr Tyr Gln Val Lys Gln Pro Arg Trp Phe Glu Thr Val Lys 
                485                 490                 495     


Val Ala Ile Pro Ile Glu Asp Val Asn Arg Ser His Leu Arg Phe Thr 
            500                 505                 510         


Phe Arg His Arg Ser Ser Gln Asp Ser Lys Asp Lys Ser Glu Lys Ile 
        515                 520                 525             


Phe Ala Leu Ala Phe Val Lys Leu Met Arg Tyr Asp Gly Thr Thr Leu 
    530                 535                 540                 


Arg Asp Gly Glu His Asp Leu Ile Val Tyr Lys Ala Glu Ala Lys Lys 
545                 550                 555                 560 


Leu Glu Asp Ala Ala Thr Tyr Leu Ser Leu Pro Ser Thr Lys Ala Glu 
                565                 570                 575     


Leu Glu Glu Lys Gly His Ser Ala Thr Gly Lys Ser Met Gln Ser Leu 
            580                 585                 590         


Gly Ser Cys Thr Ile Ser Lys Asp Ser Phe Gln Ile Ser Thr Leu Val 
        595                 600                 605             


Cys Ser Thr Lys Leu Thr Gln Asn Val Asp Leu Leu Gly Leu Leu Lys 
    610                 615                 620                 


Trp Arg Ser Asn Thr Ser Leu Leu Gln Gln Asn Leu Arg Gln Leu Met 
625                 630                 635                 640 


Lys Val Asp Gly Gly Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp 
                645                 650                 655     


Ala Leu Phe Asn Ile Met Met Glu Asn Ser Glu Ser Glu Thr Phe Asp 
            660                 665                 670         


Thr Leu Val Phe Asp Ala Leu Val Phe Ile Ile Gly Leu Ile Ala Asp 
        675                 680                 685             


Arg Lys Phe Gln His Phe Asn Pro Val Leu Glu Thr Tyr Ile Lys Lys 
    690                 695                 700                 


His Phe Ser Ala Thr Leu Ala Tyr Thr Lys Leu Thr Lys Val Leu Lys 
705                 710                 715                 720 


Asn Tyr Val Asp Gly Ala Glu Lys Pro Gly Val Asn Glu Gln Leu Tyr 
                725                 730                 735     


Lys Ala Met Lys Ala Leu Glu Ser Ile Phe Lys Phe Ile Val Arg Ser 
            740                 745                 750         


Arg Ile Leu Phe Asn Gln Leu Tyr Glu Asn Lys Gly Glu Ala Asp Phe 
        755                 760                 765             


Val Glu Ser Leu Leu Gln Leu Phe Arg Ser Ile Asn Asp Met Met Ser 
    770                 775                 780                 


Ser Met Ser Asp Gln Thr Val Arg Val Lys Gly Ala Ala Leu Lys Tyr 
785                 790                 795                 800 


Leu Pro Thr Ile Val Asn Asp Val Lys Leu Val Phe Asp Pro Lys Glu 
                805                 810                 815     


Leu Ser Lys Met Phe Thr Glu Phe Ile Leu Asn Val Pro Met Gly Leu 
            820                 825                 830         


Leu Thr Ile Gln Lys Leu Tyr Cys Leu Ile Glu Ile Val His Ser Asp 
        835                 840                 845             


Leu Phe Thr Gln His Asp Cys Arg Glu Ile Leu Leu Pro Met Met Thr 
    850                 855                 860                 


Asp Gln Leu Lys Tyr His Leu Glu Arg Gln Glu Asp Leu Glu Ala Cys 
865                 870                 875                 880 


Cys Gln Leu Leu Ser His Ile Leu Glu Val Leu Tyr Arg Lys Asp Val 
                885                 890                 895     


Gly Pro Thr Gln Arg His Val Gln Ile Ile Met Glu Lys Leu Leu Arg 
            900                 905                 910         


Thr Val Asn Arg Thr Val Ile Ser Met Gly Arg Asp Ser Glu Leu Ile 
        915                 920                 925             


Gly Asn Phe Val Ala Cys Met Thr Ala Ile Leu Arg Gln Met Glu Asp 
    930                 935                 940                 


Tyr His Tyr Ala His Leu Ile Lys Thr Phe Gly Lys Met Arg Thr Asp 
945                 950                 955                 960 


Val Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe Lys Asn Leu Ile 
                965                 970                 975     


Gly Lys Asn Val Tyr Pro Phe Asp Trp Val Ile Met Asn Met Val Gln 
            980                 985                 990         


Asn Lys Val Phe Leu Arg Ala Ile  Asn Gln Tyr Ala Asp  Met Leu Asn 
        995                 1000                 1005             


Lys Lys  Phe Leu Asp Gln Ala  Asn Phe Glu Leu Gln  Leu Trp Asn 
    1010                 1015                 1020             


Asn Tyr  Phe His Leu Ala Val  Ala Phe Leu Thr Gln  Glu Ser Leu 
    1025                 1030                 1035             


Gln Leu  Glu Asn Phe Ser Ser  Ala Lys Arg Ala Lys  Ile Leu Asn 
    1040                 1045                 1050             


Lys Tyr  Gly Asp Met Arg Arg  Gln Ile Gly Phe Glu  Ile Arg Asp 
    1055                 1060                 1065             


Met Trp  Tyr Asn Leu Gly Gln  His Lys Ile Lys Phe  Ile Pro Glu 
    1070                 1075                 1080             


Met Val  Gly Pro Ile Leu Glu  Met Thr Leu Ile Pro  Glu Thr Glu 
    1085                 1090                 1095             


Leu Arg  Lys Ala Thr Ile Pro  Ile Phe Phe Asp Met  Met Gln Cys 
    1100                 1105                 1110             


Glu Phe  His Ser Thr Arg Ser  Phe Gln Met Phe Glu  Asn Glu Ile 
    1115                 1120                 1125             


Ile Thr  Lys Leu Asp His Glu  Val Glu Gly Gly Arg  Gly Asp Glu 
    1130                 1135                 1140             


Gln Tyr  Lys Val Leu Phe Asp  Lys Ile Leu Leu Glu  His Cys Arg 
    1145                 1150                 1155             


Lys His  Lys Tyr Leu Ala Lys  Thr Gly Glu Thr Phe  Val Lys Leu 
    1160                 1165                 1170             


Val Val  Arg Leu Met Glu Arg  Leu Leu Asp Tyr Arg  Thr Ile Met 
    1175                 1180                 1185             


His Asp  Glu Asn Lys Glu Asn  Arg Met Ser Cys Thr  Val Asn Val 
    1190                 1195                 1200             


Leu Asn  Phe Tyr Lys Glu Ile  Glu Arg Glu Glu Met  Tyr Ile Arg 
    1205                 1210                 1215             


Tyr Leu  Tyr Lys Leu Cys Asp  Leu His Lys Glu Cys  Asp Asn Tyr 
    1220                 1225                 1230             


Thr Glu  Ala Ala Tyr Thr Leu  Leu Leu His Ala Lys  Leu Leu Lys 
    1235                 1240                 1245             


Trp Ser  Glu Asp Val Cys Val  Ala His Leu Thr Gln  Arg Asp Gly 
    1250                 1255                 1260             


Tyr Gln  Ala Thr Thr Gln Gly  Gln Leu Lys Glu Gln  Leu Tyr Gln 
    1265                 1270                 1275             


Glu Ile  Ile His Tyr Phe Asp  Lys Gly Lys Met Trp  Glu Glu Ala 
    1280                 1285                 1290             


Ile Ala  Leu Gly Lys Glu Leu  Ala Glu Gln Tyr Glu  Asn Glu Met 
    1295                 1300                 1305             


Phe Asp  Tyr Glu Gln Leu Ser  Glu Leu Leu Lys Lys  Gln Ala Gln 
    1310                 1315                 1320             


Phe Tyr  Glu Asn Ile Val Lys  Val Ile Arg Pro Lys  Pro Asp Tyr 
    1325                 1330                 1335             


Phe Ala  Val Gly Tyr Tyr Gly  Gln Gly Phe Pro Thr  Phe Leu Arg 
    1340                 1345                 1350             


Gly Lys  Val Phe Ile Tyr Arg  Gly Lys Glu Tyr Glu  Arg Arg Glu 
    1355                 1360                 1365             


Asp Phe  Glu Ala Arg Leu Leu  Thr Gln Phe Pro Asn  Ala Glu Lys 
    1370                 1375                 1380             


Met Lys  Thr Thr Ser Pro Pro  Gly Asp Asp Ile Lys  Asn Ser Pro 
    1385                 1390                 1395             


Gly Gln  Tyr Ile Gln Cys Phe  Thr Val Lys Pro Lys  Leu Asp Leu 
    1400                 1405                 1410             


Pro Pro  Lys Phe His Arg Pro  Val Ser Glu Gln Ile  Val Ser Phe 
    1415                 1420                 1425             


Tyr Arg  Val Asn Glu Val Gln  Arg Phe Glu Tyr Ser  Arg Pro Ile 
    1430                 1435                 1440             


Arg Lys  Gly Glu Lys Asn Pro  Asp Asn Glu Phe Ala  Asn Met Trp 
    1445                 1450                 1455             


Ile Glu  Arg Thr Ile Tyr Thr  Thr Ala Tyr Lys Leu  Pro Gly Ile 
    1460                 1465                 1470             


Leu Arg  Trp Phe Glu Val Lys  Ser Val Phe Met Val  Glu Ile Ser 
    1475                 1480                 1485             


Pro Leu  Glu Asn Ala Ile Glu  Thr Met Gln Leu Thr  Asn Asp Lys 
    1490                 1495                 1500             


Ile Asn  Ser Met Val Gln Gln  His Leu Asp Asp Pro  Ser Leu Pro 
    1505                 1510                 1515             


Ile Asn  Pro Leu Ser Met Leu  Leu Asn Gly Ile Val  Asp Pro Ala 
    1520                 1525                 1530             


Val Met  Gly Gly Phe Ala Asn  Tyr Glu Lys Ala Phe  Phe Thr Asp 
    1535                 1540                 1545             


Arg Tyr  Leu Gln Glu His Pro  Glu Ala His Glu Lys  Ile Glu Lys 
    1550                 1555                 1560             


Leu Lys  Asp Leu Ile Ala Trp  Gln Ile Pro Phe Leu  Ala Glu Gly 
    1565                 1570                 1575             


Ile Arg  Ile His Gly Asp Lys  Val Thr Glu Ala Leu  Arg Pro Phe 
    1580                 1585                 1590             


His Glu  Arg Met Glu Ala Cys  Phe Lys Gln Leu Lys  Glu Lys Val 
    1595                 1600                 1605             


Glu Lys  Glu Tyr Gly Val Arg  Ile Met Pro Ser Ser  Leu Asp Asp 
    1610                 1615                 1620             


Arg Arg  Gly Ser Arg Pro Arg  Ser Met Val Arg Ser  Phe Thr Met 
    1625                 1630                 1635             


Pro Ser  Ser Ser Arg Pro Leu  Ser Val Ala Ser Val  Ser Ser Leu 
    1640                 1645                 1650             


Ser Ser  Asp Ser Thr Pro Ser  Arg Pro Gly Ser Asp  Gly Phe Ala 
    1655                 1660                 1665             


Leu Glu  Pro Leu Leu Pro Lys  Lys Met His Ser Arg  Ser Gln Asp 
    1670                 1675                 1680             


Lys Leu  Asp Lys Asp Asp Leu  Glu Lys Glu Lys Lys  Asp Lys Lys 
    1685                 1690                 1695             


Lys Glu  Lys Arg Asn Ser Lys  His Gln Glu Ile Phe  Glu Lys Glu 
    1700                 1705                 1710             


Phe Lys  Pro Thr Asp Ile Ser  Leu Gln Gln Ser Glu  Ala Val Ile 
    1715                 1720                 1725             


Leu Ser  Glu Thr Ile Ser Pro  Leu Arg Pro Gln Arg  Pro Lys Ser 
    1730                 1735                 1740             


Gln Val  Met Asn Val Ile Gly  Ser Glu Arg Arg Phe  Ser Val Ser 
    1745                 1750                 1755             


Pro Ser  Ser Pro Ser Ser Gln  Gln Thr Pro Pro Pro  Val Thr Pro 
    1760                 1765                 1770             


Arg Ala  Lys Leu Ser Phe Ser  Met Gln Ser Ser Leu  Glu Leu Asn 
    1775                 1780                 1785             


Gly Met  Thr Gly Ala Asp Val  Ala Asp Val Pro Pro  Pro Leu Pro 
    1790                 1795                 1800             


Leu Lys  Gly Ser Val Ala Asp  Tyr Gly Asn Leu Met  Glu Asn Gln 
    1805                 1810                 1815             


Asp Leu  Leu Gly Ser Pro Thr  Pro Pro Pro Pro Pro  Pro His Gln 
    1820                 1825                 1830             


Arg His  Leu Pro Pro Pro Leu  Pro Ser Lys Thr Pro  Pro Pro Pro 
    1835                 1840                 1845             


Pro Pro  Lys Thr Thr Arg Lys  Gln Thr Ser Val Asp  Ser Gly Ile 
    1850                 1855                 1860             


Val Gln  
    1865 


<210>  3203
<211>  1830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK2__Homo_sapiens__NP_004937

<400>  3203

Met Ala Pro Trp Arg Lys Ala Asp Lys Glu Arg His Gly Val Ala Ile 
1               5                   10                  15      


Tyr Asn Phe Gln Gly Ser Gly Ala Pro Gln Leu Ser Leu Gln Ile Gly 
            20                  25                  30          


Asp Val Val Arg Ile Gln Glu Thr Cys Gly Asp Trp Tyr Arg Gly Tyr 
        35                  40                  45              


Leu Ile Lys His Lys Met Leu Gln Gly Ile Phe Pro Lys Ser Phe Ile 
    50                  55                  60                  


His Ile Lys Glu Val Thr Val Glu Lys Arg Arg Asn Thr Glu Asn Ile 
65                  70                  75                  80  


Ile Pro Ala Glu Ile Pro Leu Ala Gln Glu Val Thr Thr Thr Leu Trp 
                85                  90                  95      


Glu Trp Gly Ser Ile Trp Lys Gln Leu Tyr Val Ala Ser Lys Lys Glu 
            100                 105                 110         


Arg Phe Leu Gln Val Gln Ser Met Met Tyr Asp Leu Met Glu Trp Arg 
        115                 120                 125             


Ser Gln Leu Leu Ser Gly Thr Leu Pro Lys Asp Glu Leu Lys Glu Leu 
    130                 135                 140                 


Lys Gln Lys Val Thr Ser Lys Ile Asp Tyr Gly Asn Lys Ile Leu Glu 
145                 150                 155                 160 


Leu Asp Leu Ile Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro Asp 
                165                 170                 175     


Asn Thr Ser Val Ile Ser Leu Phe His Ala His Glu Glu Ala Thr Asp 
            180                 185                 190         


Lys Ile Thr Glu Arg Ile Lys Glu Glu Met Ser Lys Asp Gln Pro Asp 
        195                 200                 205             


Tyr Ala Met Tyr Ser Arg Ile Ser Ser Ser Pro Thr His Ser Leu Tyr 
    210                 215                 220                 


Val Phe Val Arg Asn Phe Val Cys Arg Ile Gly Glu Asp Ala Glu Leu 
225                 230                 235                 240 


Phe Met Ser Leu Tyr Asp Pro Asn Lys Gln Thr Val Ile Ser Glu Asn 
                245                 250                 255     


Tyr Leu Val Arg Trp Gly Ser Arg Gly Phe Pro Lys Glu Ile Glu Met 
            260                 265                 270         


Leu Asn Asn Leu Lys Val Val Phe Thr Asp Leu Gly Asn Lys Asp Leu 
        275                 280                 285             


Asn Arg Asp Lys Ile Tyr Leu Ile Cys Gln Ile Val Arg Val Gly Lys 
    290                 295                 300                 


Met Asp Leu Lys Asp Thr Gly Ala Lys Lys Cys Thr Gln Gly Leu Arg 
305                 310                 315                 320 


Arg Pro Phe Gly Val Ala Val Met Asp Ile Thr Asp Ile Ile Lys Gly 
                325                 330                 335     


Lys Ala Glu Ser Asp Glu Glu Lys Gln His Phe Ile Pro Phe His Pro 
            340                 345                 350         


Val Thr Ala Glu Asn Asp Phe Leu His Ser Leu Leu Gly Lys Val Ile 
        355                 360                 365             


Ala Ser Lys Gly Asp Ser Gly Gly Gln Gly Leu Trp Val Thr Met Lys 
    370                 375                 380                 


Met Leu Val Gly Asp Ile Ile Gln Ile Arg Lys Asp Tyr Pro His Leu 
385                 390                 395                 400 


Val Asp Arg Thr Thr Val Val Ala Arg Lys Leu Gly Phe Pro Glu Ile 
                405                 410                 415     


Ile Met Pro Gly Asp Val Arg Asn Asp Ile Tyr Ile Thr Leu Leu Gln 
            420                 425                 430         


Gly Asp Phe Asp Lys Tyr Asn Lys Thr Thr Gln Arg Asn Val Glu Val 
        435                 440                 445             


Ile Met Cys Val Cys Ala Glu Asp Gly Lys Thr Leu Pro Asn Ala Ile 
    450                 455                 460                 


Cys Val Gly Ala Gly Asp Lys Pro Met Asn Glu Tyr Arg Ser Val Val 
465                 470                 475                 480 


Tyr Tyr Gln Val Lys Gln Pro Arg Trp Met Glu Thr Val Lys Val Ala 
                485                 490                 495     


Val Pro Ile Glu Asp Met Gln Arg Ile His Leu Arg Phe Met Phe Arg 
            500                 505                 510         


His Arg Ser Ser Leu Glu Ser Lys Asp Lys Gly Glu Lys Asn Phe Ala 
        515                 520                 525             


Met Ser Tyr Val Lys Leu Met Lys Glu Asp Gly Thr Thr Leu His Asp 
    530                 535                 540                 


Gly Phe His Asp Leu Val Val Leu Lys Gly Asp Ser Lys Lys Met Glu 
545                 550                 555                 560 


Asp Ala Ser Ala Tyr Leu Thr Leu Pro Ser Tyr Arg His His Val Glu 
                565                 570                 575     


Asn Lys Gly Ala Thr Leu Ser Arg Ser Ser Ser Ser Val Gly Gly Leu 
            580                 585                 590         


Ser Val Ser Ser Arg Asp Val Phe Ser Ile Ser Thr Leu Val Cys Ser 
        595                 600                 605             


Thr Lys Leu Thr Gln Asn Val Gly Leu Leu Gly Leu Leu Lys Trp Arg 
    610                 615                 620                 


Met Lys Pro Gln Leu Leu Gln Glu Asn Leu Glu Lys Leu Lys Ile Val 
625                 630                 635                 640 


Asp Gly Glu Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp Ala Leu 
                645                 650                 655     


Phe Asn Ile Met Met Glu His Ser Gln Ser Asp Glu Tyr Asp Ile Leu 
            660                 665                 670         


Val Phe Asp Ala Leu Ile Tyr Ile Ile Gly Leu Ile Ala Asp Arg Lys 
        675                 680                 685             


Phe Gln His Phe Asn Thr Val Leu Glu Ala Tyr Ile Gln Gln His Phe 
    690                 695                 700                 


Ser Ala Thr Leu Ala Tyr Lys Lys Leu Met Thr Val Leu Lys Thr Tyr 
705                 710                 715                 720 


Leu Asp Thr Ser Ser Arg Gly Glu Gln Cys Glu Pro Ile Leu Arg Thr 
                725                 730                 735     


Leu Lys Ala Leu Glu Tyr Val Phe Lys Phe Ile Val Arg Ser Arg Thr 
            740                 745                 750         


Leu Phe Ser Gln Leu Tyr Glu Gly Lys Glu Gln Met Glu Phe Glu Glu 
        755                 760                 765             


Ser Met Arg Arg Leu Phe Glu Ser Ile Asn Asn Leu Met Lys Ser Gln 
    770                 775                 780                 


Tyr Lys Thr Thr Ile Leu Leu Gln Val Ala Ala Leu Lys Tyr Ile Pro 
785                 790                 795                 800 


Ser Val Leu His Asp Val Glu Met Val Phe Asp Ala Lys Leu Leu Ser 
                805                 810                 815     


Gln Leu Leu Tyr Glu Phe Tyr Thr Cys Ile Pro Pro Val Lys Leu Gln 
            820                 825                 830         


Lys Gln Lys Val Gln Ser Met Asn Glu Ile Val Gln Ser Asn Leu Phe 
        835                 840                 845             


Lys Lys Gln Glu Cys Arg Asp Ile Leu Leu Pro Val Ile Thr Lys Glu 
    850                 855                 860                 


Leu Lys Glu Leu Leu Glu Gln Lys Asp Asp Met Gln His Gln Val Leu 
865                 870                 875                 880 


Glu Arg Lys Tyr Cys Val Glu Leu Leu Asn Ser Ile Leu Glu Val Leu 
                885                 890                 895     


Ser Tyr Gln Asp Ala Ala Phe Thr Tyr His His Ile Gln Glu Ile Met 
            900                 905                 910         


Val Gln Leu Leu Arg Thr Val Asn Arg Thr Val Ile Thr Met Gly Arg 
        915                 920                 925             


Asp His Ile Leu Ile Ser His Phe Val Ala Cys Met Thr Ala Ile Leu 
    930                 935                 940                 


Asn Gln Met Gly Asp Gln His Tyr Ser Phe Tyr Ile Glu Thr Phe Gln 
945                 950                 955                 960 


Thr Ser Ser Glu Leu Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe 
                965                 970                 975     


Lys Asp Leu Ile Gly Lys Asn Val Tyr Pro Gly Asp Trp Met Ala Met 
            980                 985                 990         


Ser Met Val Gln Asn Arg Val Phe  Leu Arg Ala Ile Asn  Lys Phe Ala 
        995                 1000                 1005             


Glu Thr  Met Asn Gln Lys Phe  Leu Glu His Thr Asn  Phe Glu Phe 
    1010                 1015                 1020             


Gln Leu  Trp Asn Asn Tyr Phe  His Leu Ala Val Ala  Phe Ile Thr 
    1025                 1030                 1035             


Gln Asp  Ser Leu Gln Leu Glu  Gln Phe Ser His Ala  Lys Tyr Asn 
    1040                 1045                 1050             


Lys Ile  Leu Asn Lys Tyr Gly  Asp Met Arg Arg Leu  Ile Gly Phe 
    1055                 1060                 1065             


Ser Ile  Arg Asp Met Trp Tyr  Lys Leu Gly Gln Asn  Lys Ile Cys 
    1070                 1075                 1080             


Phe Ile  Pro Gly Met Val Gly  Pro Ile Leu Glu Met  Thr Leu Ile 
    1085                 1090                 1095             


Pro Glu  Ala Glu Leu Arg Lys  Ala Thr Ile Pro Ile  Phe Phe Asp 
    1100                 1105                 1110             


Met Met  Leu Cys Glu Tyr Gln  Arg Ser Gly Asp Phe  Lys Lys Phe 
    1115                 1120                 1125             


Glu Asn  Glu Ile Ile Leu Lys  Leu Asp His Glu Val  Glu Gly Gly 
    1130                 1135                 1140             


Arg Gly  Asp Glu Gln Tyr Met  Gln Leu Leu Glu Ser  Ile Leu Met 
    1145                 1150                 1155             


Glu Cys  Ala Ala Glu His Pro  Thr Ile Ala Lys Ser  Val Glu Asn 
    1160                 1165                 1170             


Phe Val  Asn Leu Val Lys Gly  Leu Leu Glu Lys Leu  Leu Asp Tyr 
    1175                 1180                 1185             


Arg Gly  Val Met Thr Asp Glu  Ser Lys Asp Asn Arg  Met Ser Cys 
    1190                 1195                 1200             


Thr Val  Asn Leu Leu Asn Phe  Tyr Lys Asp Asn Asn  Arg Glu Glu 
    1205                 1210                 1215             


Met Tyr  Ile Arg Tyr Leu Tyr  Lys Leu Arg Asp Leu  His Leu Asp 
    1220                 1225                 1230             


Cys Asp  Asn Tyr Thr Glu Ala  Ala Tyr Thr Leu Leu  Leu His Thr 
    1235                 1240                 1245             


Trp Leu  Leu Lys Trp Ser Asp  Glu Gln Cys Ala Ser  Gln Val Met 
    1250                 1255                 1260             


Gln Thr  Gly Gln Gln His Pro  Gln Thr His Arg Gln  Leu Lys Glu 
    1265                 1270                 1275             


Thr Leu  Tyr Glu Thr Ile Ile  Gly Tyr Phe Asp Lys  Gly Lys Met 
    1280                 1285                 1290             


Trp Glu  Glu Ala Ile Ser Leu  Cys Lys Glu Leu Ala  Glu Gln Tyr 
    1295                 1300                 1305             


Glu Met  Glu Ile Phe Asp Tyr  Glu Leu Leu Ser Gln  Asn Leu Ile 
    1310                 1315                 1320             


Gln Gln  Ala Lys Phe Tyr Glu  Ser Ile Met Lys Ile  Leu Arg Pro 
    1325                 1330                 1335             


Lys Pro  Asp Tyr Phe Ala Val  Gly Tyr Tyr Gly Gln  Gly Phe Pro 
    1340                 1345                 1350             


Ser Phe  Leu Arg Asn Lys Val  Phe Ile Tyr Arg Gly  Lys Glu Tyr 
    1355                 1360                 1365             


Glu Arg  Arg Glu Asp Phe Gln  Met Gln Leu Met Thr  Gln Phe Pro 
    1370                 1375                 1380             


Asn Ala  Glu Lys Met Asn Thr  Thr Ser Ala Pro Gly  Asp Asp Val 
    1385                 1390                 1395             


Lys Asn  Ala Pro Gly Gln Tyr  Ile Gln Cys Phe Thr  Val Gln Pro 
    1400                 1405                 1410             


Val Leu  Asp Glu His Pro Arg  Phe Lys Asn Lys Pro  Val Pro Asp 
    1415                 1420                 1425             


Gln Ile  Ile Asn Phe Tyr Lys  Ser Asn Tyr Val Gln  Arg Phe His 
    1430                 1435                 1440             


Tyr Ser  Arg Pro Val Arg Arg  Gly Thr Val Asp Pro  Glu Asn Glu 
    1445                 1450                 1455             


Phe Ala  Ser Met Trp Ile Glu  Arg Thr Ser Phe Val  Thr Ala Tyr 
    1460                 1465                 1470             


Lys Leu  Pro Gly Ile Leu Arg  Trp Phe Glu Val Val  His Met Ser 
    1475                 1480                 1485             


Gln Thr  Thr Ile Ser Pro Leu  Glu Asn Ala Ile Glu  Thr Met Ser 
    1490                 1495                 1500             


Thr Ala  Asn Glu Lys Ile Leu  Met Met Ile Asn Gln  Tyr Gln Ser 
    1505                 1510                 1515             


Asp Glu  Thr Leu Pro Ile Asn  Pro Leu Ser Met Leu  Leu Asn Gly 
    1520                 1525                 1530             


Ile Val  Asp Pro Ala Val Met  Gly Gly Phe Ala Lys  Tyr Glu Lys 
    1535                 1540                 1545             


Ala Phe  Phe Thr Glu Glu Tyr  Val Arg Asp His Pro  Glu Asp Gln 
    1550                 1555                 1560             


Asp Lys  Leu Thr His Leu Lys  Asp Leu Ile Ala Trp  Gln Ile Pro 
    1565                 1570                 1575             


Phe Leu  Gly Ala Gly Ile Lys  Ile His Glu Lys Arg  Val Ser Asp 
    1580                 1585                 1590             


Asn Leu  Arg Pro Phe His Asp  Arg Met Glu Glu Cys  Phe Lys Asn 
    1595                 1600                 1605             


Leu Lys  Met Lys Val Glu Lys  Glu Tyr Gly Val Arg  Glu Met Pro 
    1610                 1615                 1620             


Asp Phe  Asp Asp Arg Arg Val  Gly Arg Pro Arg Ser  Met Leu Arg 
    1625                 1630                 1635             


Ser Tyr  Arg Gln Met Ser Ile  Ile Ser Leu Ala Ser  Met Asn Ser 
    1640                 1645                 1650             


Asp Cys  Ser Thr Pro Ser Lys  Pro Thr Ser Glu Ser  Phe Asp Leu 
    1655                 1660                 1665             


Glu Leu  Ala Ser Pro Lys Thr  Pro Arg Val Glu Gln  Glu Glu Pro 
    1670                 1675                 1680             


Ile Ser  Pro Gly Ser Thr Leu  Pro Glu Val Lys Leu  Arg Arg Ser 
    1685                 1690                 1695             


Lys Lys  Arg Thr Lys Arg Ser  Ser Val Val Phe Ala  Asp Glu Lys 
    1700                 1705                 1710             


Ala Ala  Ala Glu Ser Asp Leu  Lys Arg Leu Ser Arg  Lys His Glu 
    1715                 1720                 1725             


Phe Met  Ser Asp Thr Asn Leu  Ser Glu His Ala Ala  Ile Pro Leu 
    1730                 1735                 1740             


Lys Ala  Ser Val Leu Ser Gln  Met Ser Phe Ala Ser  Gln Ser Met 
    1745                 1750                 1755             


Pro Thr  Ile Pro Ala Leu Ala  Leu Ser Val Ala Gly  Ile Pro Gly 
    1760                 1765                 1770             


Leu Asp  Glu Ala Asn Thr Ser  Pro Arg Leu Ser Gln  Thr Phe Leu 
    1775                 1780                 1785             


Gln Leu  Ser Asp Gly Asp Lys  Lys Thr Leu Thr Arg  Lys Lys Val 
    1790                 1795                 1800             


Asn Gln  Phe Phe Lys Thr Met  Leu Ala Ser Lys Ser  Ala Glu Glu 
    1805                 1810                 1815             


Gly Lys  Gln Ile Pro Asp Ser  Leu Ser Thr Asp Leu  
    1820                 1825                 1830 


<210>  3204
<211>  2030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK3__Homo_sapiens__NP_004938

<400>  3204

Met Trp Thr Pro Thr Glu Glu Glu Lys Tyr Gly Val Val Ile Cys Ser 
1               5                   10                  15      


Phe Arg Gly Ser Val Pro Gln Gly Leu Val Leu Glu Ile Gly Glu Thr 
            20                  25                  30          


Val Gln Ile Leu Glu Lys Cys Glu Gly Trp Tyr Arg Gly Val Ser Thr 
        35                  40                  45              


Lys Lys Pro Asn Val Lys Gly Ile Phe Pro Ala Asn Tyr Ile His Leu 
    50                  55                  60                  


Lys Lys Ala Ile Val Ser Asn Arg Gly Gln Tyr Glu Thr Val Val Pro 
65                  70                  75                  80  


Leu Glu Asp Ser Ile Val Thr Glu Val Thr Ala Thr Leu Gln Glu Trp 
                85                  90                  95      


Ala Ser Leu Trp Lys Gln Leu Tyr Val Lys His Lys Val Asp Leu Phe 
            100                 105                 110         


Tyr Lys Leu Arg His Val Met Asn Glu Leu Ile Asp Leu Arg Arg Gln 
        115                 120                 125             


Leu Leu Ser Gly His Leu Thr Gln Asp Gln Val Arg Glu Val Lys Arg 
    130                 135                 140                 


His Ile Thr Val Arg Leu Asp Trp Gly Asn Glu His Leu Gly Leu Asp 
145                 150                 155                 160 


Leu Val Pro Arg Lys Asp Phe Glu Val Val Asp Ser Asp Gln Ile Ser 
                165                 170                 175     


Val Ser Asp Leu Tyr Lys Met His Leu Ser Ser Arg Gln Ser Val Gln 
            180                 185                 190         


Gln Ser Thr Ser Gln Val Asp Thr Met Arg Pro Arg His Gly Glu Thr 
        195                 200                 205             


Cys Arg Met Pro Val Pro His His Phe Phe Leu Ser Leu Lys Ser Phe 
    210                 215                 220                 


Thr Tyr Asn Thr Ile Gly Glu Asp Thr Asp Val Phe Phe Ser Leu Tyr 
225                 230                 235                 240 


Asp Met Arg Glu Gly Lys Gln Ile Ser Glu Arg Phe Leu Val Arg Leu 
                245                 250                 255     


Asn Lys Asn Gly Gly Pro Arg Asn Pro Glu Lys Ile Glu Arg Met Cys 
            260                 265                 270         


Ala Leu Phe Thr Asp Leu Ser Ser Lys Asp Met Lys Arg Asp Leu Tyr 
        275                 280                 285             


Ile Val Ala His Val Ile Arg Ile Gly Arg Met Leu Leu Asn Asp Ser 
    290                 295                 300                 


Lys Lys Gly Pro Pro His Leu His Tyr Arg Arg Pro Tyr Gly Cys Ala 
305                 310                 315                 320 


Val Leu Ser Ile Leu Asp Val Leu Gln Ser Leu Thr Glu Val Lys Glu 
                325                 330                 335     


Glu Lys Asp Phe Val Leu Lys Val Tyr Thr Cys Asn Asn Glu Ser Glu 
            340                 345                 350         


Trp Ser Gln Ile His Glu Asn Ile Ile Arg Lys Ser Ser Ala Lys Tyr 
        355                 360                 365             


Ser Ala Pro Ser Ala Ser His Gly Leu Ile Ile Ser Leu Gln Leu Leu 
    370                 375                 380                 


Arg Gly Asp Met Glu Gln Ile Arg Arg Glu Asn Pro Met Ile Phe Asn 
385                 390                 395                 400 


Arg Gly Leu Ala Ile Thr Arg Lys Leu Gly Phe Pro Asp Val Ile Met 
                405                 410                 415     


Pro Gly Asp Ile Arg Asn Asp Leu Tyr Leu Thr Leu Glu Lys Gly Asp 
            420                 425                 430         


Phe Glu Arg Gly Gly Lys Ser Val Gln Lys Asn Ile Glu Val Thr Met 
        435                 440                 445             


Tyr Val Leu Tyr Ala Asp Gly Glu Ile Leu Lys Asp Cys Ile Ser Leu 
    450                 455                 460                 


Gly Ser Gly Glu Pro Asn Arg Ser Ser Tyr His Ser Phe Val Leu Tyr 
465                 470                 475                 480 


His Ser Asn Ser Pro Arg Trp Gly Glu Ile Ile Lys Leu Pro Ile Pro 
                485                 490                 495     


Ile Asp Arg Phe Arg Gly Ser His Leu Arg Phe Glu Phe Arg His Cys 
            500                 505                 510         


Ser Thr Lys Asp Lys Gly Glu Lys Lys Leu Phe Gly Phe Ala Phe Ser 
        515                 520                 525             


Thr Leu Met Arg Asp Asp Gly Thr Thr Leu Ser Asp Asp Ile His Glu 
    530                 535                 540                 


Leu Tyr Val Tyr Lys Cys Asp Glu Asn Ser Thr Phe Asn Asn His Ala 
545                 550                 555                 560 


Leu Tyr Leu Gly Leu Pro Cys Cys Lys Glu Asp Tyr Asn Gly Cys Pro 
                565                 570                 575     


Asn Ile Pro Ser Ser Leu Ile Phe Gln Arg Ser Thr Lys Glu Ser Phe 
            580                 585                 590         


Phe Ile Ser Thr Gln Leu Ser Ser Thr Lys Leu Thr Gln Asn Val Asp 
        595                 600                 605             


Leu Leu Ala Leu Leu Lys Trp Lys Ala Phe Pro Asp Arg Ile Met Asp 
    610                 615                 620                 


Val Leu Gly Arg Leu Arg His Val Ser Gly Glu Glu Ile Val Lys Phe 
625                 630                 635                 640 


Leu Gln Asp Ile Leu Asp Thr Leu Phe Val Ile Leu Asp Asp Asn Thr 
                645                 650                 655     


Glu Lys Tyr Gly Leu Leu Val Phe Gln Ser Leu Val Phe Ile Ile Asn 
            660                 665                 670         


Leu Leu Arg Asp Ile Lys Tyr Phe His Phe Arg Pro Val Met Asp Thr 
        675                 680                 685             


Tyr Ile Gln Lys His Phe Ala Gly Ala Leu Ala Tyr Lys Glu Leu Ile 
    690                 695                 700                 


Arg Cys Leu Lys Trp Tyr Met Asp Cys Ser Ala Glu Leu Ile Arg Gln 
705                 710                 715                 720 


Asp His Ile Gln Glu Ala Met Arg Ala Leu Glu Tyr Leu Phe Lys Phe 
                725                 730                 735     


Ile Val Gln Ser Arg Ile Leu Tyr Ser Arg Ala Thr Cys Gly Met Glu 
            740                 745                 750         


Glu Glu Gln Phe Arg Ser Ser Ile Gln Glu Leu Phe Gln Ser Ile Arg 
        755                 760                 765             


Phe Val Leu Ser Leu Asp Ser Arg Asn Ser Glu Thr Leu Leu Phe Thr 
    770                 775                 780                 


Gln Ala Ala Leu Leu Asn Ser Phe Pro Thr Ile Phe Asp Glu Leu Leu 
785                 790                 795                 800 


Gln Met Phe Thr Val Gln Glu Val Ala Glu Phe Val Arg Gly Thr Leu 
                805                 810                 815     


Gly Ser Met Pro Ser Thr Val His Ile Gly Gln Ser Met Asp Val Val 
            820                 825                 830         


Lys Leu Gln Ser Ile Ala Arg Thr Val Asp Ser Arg Leu Phe Ser Phe 
        835                 840                 845             


Ser Glu Ser Arg Arg Ile Leu Leu Pro Val Val Leu His His Ile His 
    850                 855                 860                 


Leu His Leu Arg Gln Gln Lys Glu Leu Leu Ile Cys Ser Gly Ile Leu 
865                 870                 875                 880 


Gly Ser Ile Phe Ser Ile Val Lys Thr Ser Ser Leu Glu Ala Asp Val 
                885                 890                 895     


Met Glu Glu Val Glu Met Met Val Glu Ser Leu Leu Asp Val Leu Leu 
            900                 905                 910         


Gln Thr Leu Leu Thr Ile Met Ser Lys Ser His Ala Gln Glu Ala Val 
        915                 920                 925             


Arg Gly Gln Arg Cys Pro Gln Cys Thr Ala Glu Ile Thr Gly Glu Tyr 
    930                 935                 940                 


Val Ser Cys Leu Leu Ser Leu Leu Arg Gln Met Cys Asp Thr His Phe 
945                 950                 955                 960 


Gln His Leu Leu Asp Asn Phe Gln Ser Lys Asp Glu Leu Lys Glu Phe 
                965                 970                 975     


Leu Leu Lys Ile Phe Cys Val Phe Arg Asn Leu Met Lys Met Ser Val 
            980                 985                 990         


Phe Pro Arg Asp Trp Met Val Met  Arg Leu Leu Thr Ser  Asn Ile Ile 
        995                 1000                 1005             


Val Thr  Thr Val Gln Tyr Leu  Ser Ser Ala Leu His  Lys Asn Phe 
    1010                 1015                 1020             


Thr Glu  Thr Asp Phe Asp Phe  Lys Val Trp Asn Ser  Tyr Phe Ser 
    1025                 1030                 1035             


Leu Ala  Val Leu Phe Ile Asn  Gln Pro Ser Leu Gln  Leu Glu Ile 
    1040                 1045                 1050             


Ile Thr  Ser Ala Lys Arg Lys  Lys Ile Leu Asp Lys  Tyr Gly Asp 
    1055                 1060                 1065             


Met Arg  Val Met Met Ala Tyr  Glu Leu Phe Ser Met  Trp Gln Asn 
    1070                 1075                 1080             


Leu Gly  Glu His Lys Ile His  Phe Ile Pro Gly Met  Ile Gly Pro 
    1085                 1090                 1095             


Phe Leu  Gly Val Thr Leu Val  Pro Gln Pro Glu Val  Arg Asn Ile 
    1100                 1105                 1110             


Met Ile  Pro Ile Phe His Asp  Met Met Asp Trp Glu  Gln Arg Lys 
    1115                 1120                 1125             


Asn Gly  Asn Phe Lys Gln Val  Glu Ala Glu Leu Ile  Asp Lys Leu 
    1130                 1135                 1140             


Asp Ser  Met Val Ser Glu Gly  Lys Gly Asp Glu Ser  Tyr Arg Glu 
    1145                 1150                 1155             


Leu Phe  Ser Leu Leu Thr Gln  Leu Phe Gly Pro Tyr  Pro Ser Leu 
    1160                 1165                 1170             


Leu Glu  Lys Val Glu Gln Glu  Thr Trp Arg Glu Thr  Gly Ile Ser 
    1175                 1180                 1185             


Phe Val  Thr Ser Val Thr Arg  Leu Met Glu Arg Leu  Leu Asp Tyr 
    1190                 1195                 1200             


Arg Asp  Cys Met Lys Gly Glu  Glu Thr Glu Asn Lys  Lys Ile Gly 
    1205                 1210                 1215             


Cys Thr  Val Asn Leu Met Asn  Phe Tyr Lys Ser Glu  Ile Asn Lys 
    1220                 1225                 1230             


Glu Glu  Met Tyr Ile Arg Tyr  Ile His Lys Leu Cys  Asp Met His 
    1235                 1240                 1245             


Leu Gln  Ala Glu Asn Tyr Thr  Glu Ala Ala Phe Thr  Leu Leu Leu 
    1250                 1255                 1260             


Tyr Cys  Glu Leu Leu Gln Trp  Glu Asp Arg Pro Leu  Arg Glu Phe 
    1265                 1270                 1275             


Leu His  Tyr Pro Ser Gln Thr  Glu Trp Gln Arg Lys  Glu Gly Leu 
    1280                 1285                 1290             


Cys Arg  Lys Ile Ile His Tyr  Phe Asn Lys Gly Lys  Ser Trp Glu 
    1295                 1300                 1305             


Phe Gly  Ile Pro Leu Cys Arg  Glu Leu Ala Cys Gln  Tyr Glu Ser 
    1310                 1315                 1320             


Leu Tyr  Asp Tyr Gln Ser Leu  Ser Trp Ile Arg Lys  Met Glu Ala 
    1325                 1330                 1335             


Ser Tyr  Tyr Asp Asn Ile Met  Glu Gln Gln Arg Leu  Glu Pro Glu 
    1340                 1345                 1350             


Phe Phe  Arg Val Gly Phe Tyr  Gly Arg Lys Phe Pro  Phe Phe Leu 
    1355                 1360                 1365             


Arg Asn  Lys Glu Tyr Val Cys  Arg Gly His Asp Tyr  Glu Arg Leu 
    1370                 1375                 1380             


Glu Ala  Phe Gln Gln Arg Met  Leu Ser Glu Phe Pro  Gln Ala Val 
    1385                 1390                 1395             


Ala Met  Gln His Pro Asn His  Pro Asp Asp Ala Ile  Leu Gln Cys 
    1400                 1405                 1410             


Asp Ala  Gln Tyr Leu Gln Ile  Tyr Ala Val Thr Pro  Ile Pro Asp 
    1415                 1420                 1425             


Tyr Val  Asp Val Leu Gln Met  Asp Arg Val Pro Asp  Arg Val Lys 
    1430                 1435                 1440             


Ser Phe  Tyr Arg Val Asn Asn  Val Arg Lys Phe Arg  Tyr Asp Arg 
    1445                 1450                 1455             


Pro Phe  His Lys Gly Pro Lys  Asp Lys Glu Asn Glu  Phe Lys Ser 
    1460                 1465                 1470             


Leu Trp  Ile Glu Arg Thr Thr  Leu Thr Leu Thr His  Ser Leu Pro 
    1475                 1480                 1485             


Gly Ile  Ser Arg Trp Phe Glu  Val Glu Arg Arg Glu  Leu Val Glu 
    1490                 1495                 1500             


Val Ser  Pro Leu Glu Asn Ala  Ile Gln Val Val Glu  Asn Lys Asn 
    1505                 1510                 1515             


Gln Glu  Leu Arg Ser Leu Ile  Ser Gln Tyr Gln His  Lys Gln Val 
    1520                 1525                 1530             


His Gly  Asn Ile Asn Leu Leu  Ser Met Cys Leu Asn  Gly Val Ile 
    1535                 1540                 1545             


Asp Ala  Ala Val Asn Gly Gly  Ile Ala Arg Tyr Gln  Glu Ala Phe 
    1550                 1555                 1560             


Phe Asp  Lys Asp Tyr Ile Asn  Lys His Pro Gly Asp  Ala Glu Lys 
    1565                 1570                 1575             


Ile Thr  Gln Leu Lys Glu Leu  Met Gln Glu Gln Val  His Val Leu 
    1580                 1585                 1590             


Gly Val  Gly Leu Ala Val His  Glu Lys Phe Val His  Pro Glu Met 
    1595                 1600                 1605             


Arg Pro  Leu His Lys Lys Leu  Ile Asp Gln Phe Gln  Met Met Arg 
    1610                 1615                 1620             


Ala Ser  Leu Tyr His Glu Phe  Pro Gly Leu Asp Lys  Leu Ser Pro 
    1625                 1630                 1635             


Ala Cys  Ser Gly Thr Ser Thr  Pro Arg Gly Asn Val  Leu Ala Ser 
    1640                 1645                 1650             


His Ser  Pro Met Ser Pro Glu  Ser Ile Lys Met Thr  His Arg His 
    1655                 1660                 1665             


Ser Pro  Met Asn Leu Met Gly  Thr Gly Arg His Ser  Ser Ser Ser 
    1670                 1675                 1680             


Leu Ser  Ser His Ala Ser Ser  Glu Ala Gly Asn Met  Val Met Leu 
    1685                 1690                 1695             


Gly Asp  Gly Ser Met Gly Asp  Ala Pro Glu Asp Leu  Tyr His His 
    1700                 1705                 1710             


Met Gln  Leu Ala Tyr Pro Asn  Pro Arg Tyr Gln Gly  Ser Val Thr 
    1715                 1720                 1725             


Asn Val  Ser Val Leu Ser Ser  Ser Gln Ala Ser Pro  Ser Ser Ser 
    1730                 1735                 1740             


Ser Leu  Ser Ser Thr His Ser  Ala Pro Ser Gln Met  Ile Thr Ser 
    1745                 1750                 1755             


Ala Pro  Ser Ser Ala Arg Gly  Ser Pro Ser Leu Pro  Asp Lys Tyr 
    1760                 1765                 1770             


Arg His  Ala Arg Glu Met Met  Leu Leu Leu Pro Thr  Tyr Arg Asp 
    1775                 1780                 1785             


Arg Pro  Ser Ser Ala Met Tyr  Pro Ala Ala Ile Leu  Glu Asn Gly 
    1790                 1795                 1800             


Gln Pro  Pro Asn Phe Gln Arg  Ala Leu Phe Gln Gln  Val Val Gly 
    1805                 1810                 1815             


Ala Cys  Lys Pro Cys Ser Asp  Pro Asn Leu Ser Val  Ala Glu Lys 
    1820                 1825                 1830             


Gly His  Tyr Ser Leu His Phe  Asp Ala Phe His His  Pro Leu Gly 
    1835                 1840                 1845             


Asp Thr  Pro Pro Ala Leu Pro  Ala Arg Thr Leu Arg  Lys Ser Pro 
    1850                 1855                 1860             


Leu His  Pro Ile Pro Ala Ser  Pro Thr Ser Pro Gln  Ser Gly Leu 
    1865                 1870                 1875             


Asp Gly  Ser Asn Ser Thr Leu  Ser Gly Ser Ala Ser  Ser Gly Val 
    1880                 1885                 1890             


Ser Ser  Leu Ser Glu Ser Asn  Phe Gly His Ser Ser  Glu Ala Pro 
    1895                 1900                 1905             


Pro Arg  Thr Asp Thr Met Asp  Ser Met Pro Ser Gln  Ala Trp Asn 
    1910                 1915                 1920             


Ala Asp  Glu Asp Leu Glu Pro  Pro Tyr Leu Pro Val  His Tyr Ser 
    1925                 1930                 1935             


Leu Ser  Glu Ser Ala Val Leu  Asp Ser Ile Lys Ala  Gln Pro Cys 
    1940                 1945                 1950             


Arg Ser  His Ser Ala Pro Gly  Cys Val Ile Pro Gln  Asp Pro Met 
    1955                 1960                 1965             


Asp Pro  Pro Ala Leu Pro Pro  Lys Pro Tyr His Pro  Arg Leu Pro 
    1970                 1975                 1980             


Ala Leu  Glu His Asp Glu Gly  Val Leu Leu Arg Glu  Glu Thr Glu 
    1985                 1990                 1995             


Arg Pro  Arg Gly Leu His Arg  Lys Ala Pro Leu Pro  Pro Gly Ser 
    2000                 2005                 2010             


Ala Lys  Glu Glu Gln Ala Arg  Met Ala Trp Glu His  Gly Arg Gly 
    2015                 2020                 2025             


Glu Gln  
    2030 


<210>  3205
<211>  1966
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK4__Homo_sapiens__NP_055520

<400>  3205

Met Trp Ile Pro Thr Glu His Glu Lys Tyr Gly Val Val Ile Ala Ser 
1               5                   10                  15      


Phe Arg Gly Thr Val Pro Tyr Gly Leu Ser Leu Glu Ile Gly Asp Thr 
            20                  25                  30          


Val Gln Ile Leu Glu Lys Cys Asp Gly Trp Tyr Arg Gly Phe Ala Leu 
        35                  40                  45              


Lys Asn Pro Asn Ile Lys Gly Ile Phe Pro Ser Ser Tyr Val His Leu 
    50                  55                  60                  


Lys Asn Ala Cys Val Lys Asn Lys Gly Gln Phe Glu Met Val Ile Pro 
65                  70                  75                  80  


Thr Glu Asp Ser Val Ile Thr Glu Met Thr Ser Thr Leu Arg Asp Trp 
                85                  90                  95      


Gly Thr Met Trp Lys Gln Leu Tyr Val Arg Asn Glu Gly Asp Leu Phe 
            100                 105                 110         


His Arg Leu Trp His Ile Met Asn Glu Ile Leu Asp Leu Arg Arg Gln 
        115                 120                 125             


Val Leu Val Gly His Leu Thr His Asp Arg Met Lys Asp Val Lys Arg 
    130                 135                 140                 


His Ile Thr Ala Arg Leu Asp Trp Gly Asn Glu Gln Leu Gly Leu Asp 
145                 150                 155                 160 


Leu Val Pro Arg Lys Glu Tyr Ala Met Val Asp Pro Glu Asp Ile Ser 
                165                 170                 175     


Ile Thr Glu Leu Tyr Arg Leu Met Glu His Arg His Arg Lys Lys Asp 
            180                 185                 190         


Thr Pro Val Gln Ala Ser Ser His His Leu Phe Val Gln Met Lys Ser 
        195                 200                 205             


Leu Met Cys Ser Asn Leu Gly Glu Glu Leu Glu Val Ile Phe Ser Leu 
    210                 215                 220                 


Phe Asp Ser Lys Glu Asn Arg Pro Ile Ser Glu Arg Phe Phe Leu Arg 
225                 230                 235                 240 


Leu Asn Arg Asn Gly Leu Pro Lys Ala Pro Asp Lys Pro Glu Arg His 
                245                 250                 255     


Cys Ser Leu Phe Val Asp Leu Gly Ser Ser Glu Leu Arg Lys Asp Ile 
            260                 265                 270         


Tyr Ile Thr Val His Ile Ile Arg Ile Gly Arg Met Gly Ala Gly Glu 
        275                 280                 285             


Lys Lys Asn Ala Cys Ser Val Gln Tyr Arg Arg Pro Phe Gly Cys Ala 
    290                 295                 300                 


Val Leu Ser Ile Ala Asp Leu Leu Thr Gly Glu Thr Lys Asp Asp Leu 
305                 310                 315                 320 


Ile Leu Lys Val Tyr Met Cys Asn Thr Glu Ser Glu Trp Tyr Gln Ile 
                325                 330                 335     


His Glu Asn Ile Ile Lys Lys Leu Asn Ala Arg Tyr Asn Leu Thr Gly 
            340                 345                 350         


Ser Asn Ala Gly Leu Ala Val Ser Leu Gln Leu Leu His Gly Asp Ile 
        355                 360                 365             


Glu Gln Ile Arg Arg Glu Tyr Ser Ser Val Phe Ser His Gly Val Ser 
    370                 375                 380                 


Ile Thr Arg Lys Leu Gly Phe Ser Asn Ile Ile Met Pro Gly Glu Met 
385                 390                 395                 400 


Arg Asn Asp Leu Tyr Ile Thr Ile Glu Arg Gly Glu Phe Glu Lys Gly 
                405                 410                 415     


Gly Lys Ser Val Ala Arg Asn Val Glu Val Thr Met Phe Ile Val Asp 
            420                 425                 430         


Ser Ser Gly Gln Thr Leu Lys Asp Phe Ile Ser Phe Gly Ser Gly Glu 
        435                 440                 445             


Pro Pro Ala Ser Glu Tyr His Ser Phe Val Leu Tyr His Asn Asn Ser 
    450                 455                 460                 


Pro Arg Trp Ser Glu Leu Leu Lys Leu Pro Ile Pro Val Asp Lys Phe 
465                 470                 475                 480 


Arg Gly Ala His Ile Arg Phe Glu Phe Arg His Cys Ser Thr Lys Glu 
                485                 490                 495     


Lys Gly Glu Lys Lys Leu Phe Gly Phe Ser Phe Val Pro Leu Met Gln 
            500                 505                 510         


Glu Asp Gly Arg Thr Leu Pro Asp Gly Thr His Glu Leu Ile Val His 
        515                 520                 525             


Lys Cys Glu Glu Asn Thr Asn Leu Gln Asp Thr Thr Arg Tyr Leu Lys 
    530                 535                 540                 


Leu Pro Phe Ser Lys Gly Ile Phe Leu Gly Asn Asn Asn Gln Ala Met 
545                 550                 555                 560 


Lys Ala Thr Lys Glu Ser Phe Cys Ile Thr Ser Phe Leu Cys Ser Thr 
                565                 570                 575     


Lys Leu Thr Gln Asn Gly Asp Met Leu Asp Leu Leu Lys Trp Arg Thr 
            580                 585                 590         


His Pro Asp Lys Ile Thr Gly Cys Leu Ser Lys Leu Lys Glu Ile Asp 
        595                 600                 605             


Gly Ser Glu Ile Val Lys Phe Leu Gln Asp Thr Leu Asp Thr Leu Phe 
    610                 615                 620                 


Gly Ile Leu Asp Glu Asn Ser Gln Lys Tyr Gly Ser Lys Val Phe Asp 
625                 630                 635                 640 


Ser Leu Val His Ile Ile Asn Leu Leu Gln Asp Ser Lys Phe His His 
                645                 650                 655     


Phe Lys Pro Val Met Asp Thr Tyr Ile Glu Ser His Phe Ala Gly Ala 
            660                 665                 670         


Leu Ala Tyr Arg Asp Leu Ile Lys Val Leu Lys Trp Tyr Val Asp Arg 
        675                 680                 685             


Ile Thr Glu Ala Glu Arg Gln Glu His Ile Gln Glu Val Leu Lys Ala 
    690                 695                 700                 


Gln Glu Tyr Ile Phe Lys Tyr Ile Val Gln Ser Arg Arg Leu Phe Ser 
705                 710                 715                 720 


Leu Ala Thr Gly Gly Gln Asn Glu Glu Glu Phe Arg Cys Cys Ile Gln 
                725                 730                 735     


Glu Leu Leu Met Ser Val Arg Phe Phe Leu Ser Gln Glu Ser Lys Gly 
            740                 745                 750         


Ser Gly Ala Leu Ser Gln Ser Gln Ala Val Phe Leu Ser Ser Phe Pro 
        755                 760                 765             


Ala Val Tyr Ser Glu Leu Leu Lys Leu Phe Asp Val Arg Glu Val Ala 
    770                 775                 780                 


Asn Leu Val Gln Asp Thr Leu Gly Ser Leu Pro Thr Ile Leu His Val 
785                 790                 795                 800 


Asp Asp Ser Leu Gln Ala Ile Lys Leu Gln Cys Ile Gly Lys Thr Val 
                805                 810                 815     


Glu Ser Gln Leu Tyr Thr Asn Pro Asp Ser Arg Tyr Ile Leu Leu Pro 
            820                 825                 830         


Val Val Leu His His Leu His Ile His Leu Gln Glu Gln Lys Asp Leu 
        835                 840                 845             


Ile Met Cys Ala Arg Ile Leu Ser Asn Val Phe Cys Leu Ile Lys Lys 
    850                 855                 860                 


Asn Ser Ser Glu Lys Ser Val Leu Glu Glu Ile Asp Val Ile Val Ala 
865                 870                 875                 880 


Ser Leu Leu Asp Ile Leu Leu Arg Thr Ile Leu Glu Ile Thr Ser Arg 
                885                 890                 895     


Pro Gln Pro Ser Ser Ser Ala Met Arg Phe Gln Phe Gln Asp Val Thr 
            900                 905                 910         


Gly Glu Phe Val Ala Cys Leu Leu Ser Leu Leu Arg Gln Met Thr Asp 
        915                 920                 925             


Arg His Tyr Gln Gln Leu Leu Asp Ser Phe Asn Thr Lys Glu Glu Leu 
    930                 935                 940                 


Arg Asp Phe Leu Leu Gln Ile Phe Thr Val Phe Arg Ile Leu Ile Arg 
945                 950                 955                 960 


Pro Glu Met Phe Pro Lys Asp Trp Thr Val Met Arg Leu Val Ala Asn 
                965                 970                 975     


Asn Val Ile Ile Thr Thr Val Leu Tyr Leu Ser Asp Ala Leu Arg Lys 
            980                 985                 990         


Asn Phe Leu Asn Glu Asn Phe Asp  Tyr Lys Ile Trp Asp  Ser Tyr Phe 
        995                 1000                 1005             


Tyr Leu  Ala Val Ile Phe Ile  Asn Gln Leu Cys Leu  Gln Leu Glu 
    1010                 1015                 1020             


Met Phe  Thr Pro Ser Lys Lys  Lys Lys Val Leu Glu  Lys Tyr Gly 
    1025                 1030                 1035             


Asp Met  Arg Val Thr Met Gly  Cys Glu Ile Phe Ser  Met Trp Gln 
    1040                 1045                 1050             


Asn Leu  Gly Glu His Lys Leu  His Phe Ile Pro Ala  Leu Ile Gly 
    1055                 1060                 1065             


Pro Phe  Leu Glu Val Thr Leu  Ile Pro Gln Pro Asp  Leu Arg Asn 
    1070                 1075                 1080             


Val Met  Ile Pro Ile Phe His  Asp Met Met Asp Trp  Glu Gln Arg 
    1085                 1090                 1095             


Arg Ser  Gly Asn Phe Lys Gln  Val Glu Ala Lys Leu  Ile Asp Lys 
    1100                 1105                 1110             


Leu Asp  Ser Leu Met Ser Glu  Gly Lys Gly Asp Glu  Thr Tyr Arg 
    1115                 1120                 1125             


Glu Leu  Phe Asn Ser Ile Leu  Leu Lys Lys Ile Glu  Arg Glu Thr 
    1130                 1135                 1140             


Trp Arg  Glu Ser Gly Val Ser  Leu Ile Ala Thr Val  Thr Arg Leu 
    1145                 1150                 1155             


Met Glu  Arg Leu Leu Asp Tyr  Arg Asp Cys Met Lys  Met Gly Glu 
    1160                 1165                 1170             


Val Asp  Gly Lys Lys Ile Gly  Cys Thr Val Ser Leu  Leu Asn Phe 
    1175                 1180                 1185             


Tyr Lys  Thr Glu Leu Asn Lys  Glu Glu Met Tyr Ile  Arg Tyr Ile 
    1190                 1195                 1200             


His Lys  Leu Tyr Asp Leu His  Leu Lys Ala Gln Asn  Phe Thr Glu 
    1205                 1210                 1215             


Ala Ala  Tyr Thr Leu Leu Leu  Tyr Asp Glu Leu Leu  Glu Trp Ser 
    1220                 1225                 1230             


Asp Arg  Pro Leu Arg Glu Phe  Leu Thr Tyr Pro Met  Gln Thr Glu 
    1235                 1240                 1245             


Trp Gln  Arg Lys Glu His Leu  His Leu Thr Ile Ile  Gln Asn Phe 
    1250                 1255                 1260             


Asp Arg  Gly Lys Cys Trp Glu  Asn Gly Ile Ile Leu  Cys Arg Lys 
    1265                 1270                 1275             


Ile Ala  Glu Gln Tyr Glu Ser  Tyr Tyr Asp Tyr Arg  Asn Leu Ser 
    1280                 1285                 1290             


Lys Met  Arg Met Met Glu Ala  Ser Leu Tyr Asp Lys  Ile Met Asp 
    1295                 1300                 1305             


Gln Gln  Arg Leu Glu Pro Glu  Phe Phe Arg Val Gly  Phe Tyr Gly 
    1310                 1315                 1320             


Lys Lys  Phe Pro Phe Phe Leu  Arg Asn Lys Glu Phe  Val Cys Arg 
    1325                 1330                 1335             


Gly His  Asp Tyr Glu Arg Leu  Glu Ala Phe Gln Gln  Arg Met Leu 
    1340                 1345                 1350             


Asn Glu  Phe Pro His Ala Ile  Ala Met Gln His Ala  Asn Gln Pro 
    1355                 1360                 1365             


Asp Glu  Thr Ile Phe Gln Ala  Glu Ala Gln Tyr Leu  Gln Ile Tyr 
    1370                 1375                 1380             


Ala Val  Thr Pro Ile Pro Glu  Ser Gln Glu Val Leu  Gln Arg Glu 
    1385                 1390                 1395             


Gly Val  Pro Asp Asn Ile Lys  Ser Phe Tyr Lys Val  Asn His Ile 
    1400                 1405                 1410             


Trp Lys  Phe Arg Tyr Asp Arg  Pro Phe His Lys Gly  Thr Lys Asp 
    1415                 1420                 1425             


Lys Glu  Asn Glu Phe Lys Ser  Leu Trp Val Glu Arg  Thr Ser Leu 
    1430                 1435                 1440             


Tyr Leu  Val Gln Ser Leu Pro  Gly Ile Ser Arg Trp  Phe Glu Val 
    1445                 1450                 1455             


Glu Lys  Arg Glu Val Val Glu  Met Ser Pro Leu Glu  Asn Ala Ile 
    1460                 1465                 1470             


Glu Val  Leu Glu Asn Lys Asn  Gln Gln Leu Lys Thr  Leu Ile Ser 
    1475                 1480                 1485             


Gln Cys  Gln Thr Arg Gln Met  Gln Asn Ile Asn Pro  Leu Thr Met 
    1490                 1495                 1500             


Cys Leu  Asn Gly Val Ile Asp  Ala Ala Val Asn Gly  Gly Val Ser 
    1505                 1510                 1515             


Arg Tyr  Gln Glu Ala Phe Phe  Val Lys Glu Tyr Ile  Leu Ser His 
    1520                 1525                 1530             


Pro Glu  Asp Gly Glu Lys Ile  Ala Arg Leu Arg Glu  Leu Met Leu 
    1535                 1540                 1545             


Glu Gln  Ala Gln Ile Leu Glu  Phe Gly Leu Ala Val  His Glu Lys 
    1550                 1555                 1560             


Phe Val  Pro Gln Asp Met Arg  Pro Leu His Lys Lys  Leu Val Asp 
    1565                 1570                 1575             


Gln Phe  Phe Val Met Lys Ser  Ser Leu Gly Ile Gln  Glu Phe Ser 
    1580                 1585                 1590             


Ala Cys  Met Gln Ala Ser Pro  Val His Phe Pro Asn  Gly Ser Pro 
    1595                 1600                 1605             


Arg Val  Cys Arg Asn Ser Ala  Pro Ala Ser Val Ser  Pro Asp Gly 
    1610                 1615                 1620             


Thr Arg  Val Ile Pro Arg Arg  Ser Pro Leu Ser Tyr  Pro Ala Val 
    1625                 1630                 1635             


Asn Arg  Tyr Ser Ser Ser Ser  Leu Ser Ser Gln Ala  Ser Ala Glu 
    1640                 1645                 1650             


Val Ser  Asn Ile Thr Gly Gln  Ser Glu Ser Ser Asp  Glu Val Phe 
    1655                 1660                 1665             


Asn Met  Gln Pro Ser Pro Ser  Thr Ser Ser Leu Ser  Ser Thr His 
    1670                 1675                 1680             


Ser Ala  Ser Pro Asn Val Thr  Ser Ser Ala Pro Ser  Ser Ala Arg 
    1685                 1690                 1695             


Ala Ser  Pro Leu Leu Ser Asp  Lys His Lys His Ser  Arg Glu Asn 
    1700                 1705                 1710             


Ser Cys  Leu Ser Pro Arg Glu  Arg Pro Cys Ser Ala  Ile Tyr Pro 
    1715                 1720                 1725             


Thr Pro  Val Glu Pro Ser Gln  Arg Met Leu Phe Asn  His Ile Gly 
    1730                 1735                 1740             


Asp Gly  Ala Leu Pro Arg Ser  Asp Pro Asn Leu Ser  Ala Pro Glu 
    1745                 1750                 1755             


Lys Ala  Val Asn Pro Thr Pro  Ser Ser Trp Ser Leu  Asp Ser Gly 
    1760                 1765                 1770             


Lys Glu  Ala Lys Asn Met Ser  Asp Ser Gly Lys Leu  Ile Ser Pro 
    1775                 1780                 1785             


Pro Val  Pro Pro Arg Pro Thr  Gln Thr Ala Ser Pro  Ala Arg His 
    1790                 1795                 1800             


Thr Thr  Ser Val Ser Pro Ser  Pro Ala Gly Arg Ser  Pro Leu Lys 
    1805                 1810                 1815             


Gly Ser  Val Gln Ser Phe Thr  Pro Ser Pro Val Glu  Tyr His Ser 
    1820                 1825                 1830             


Pro Gly  Leu Ile Ser Asn Ser  Pro Val Leu Ser Gly  Ser Tyr Ser 
    1835                 1840                 1845             


Ser Gly  Ile Ser Ser Leu Ser  Arg Cys Ser Thr Ser  Glu Thr Ser 
    1850                 1855                 1860             


Gly Phe  Glu Asn Gln Val Asn  Glu Gln Ser Ala Pro  Leu Pro Val 
    1865                 1870                 1875             


Pro Val  Pro Val Pro Val Pro  Ser Tyr Gly Gly Glu  Glu Pro Val 
    1880                 1885                 1890             


Arg Lys  Glu Ser Lys Thr Pro  Pro Pro Tyr Ser Val  Tyr Glu Arg 
    1895                 1900                 1905             


Thr Leu  Arg Arg Pro Val Pro  Leu Pro His Ser Leu  Ser Ile Pro 
    1910                 1915                 1920             


Val Thr  Ser Glu Pro Pro Ala  Leu Pro Pro Lys Pro  Leu Ala Ala 
    1925                 1930                 1935             


Arg Ser  Ser His Leu Glu Asn  Gly Ala Arg Arg Thr  Asp Pro Gly 
    1940                 1945                 1950             


Pro Arg  Pro Arg Pro Leu Pro  Arg Lys Val Ser Gln  Leu 
    1955                 1960                 1965     


<210>  3206
<211>  1870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK5__Homo_sapiens__NP_079216

<400>  3206

Met Ala Arg Trp Ile Pro Thr Lys Arg Gln Lys Tyr Gly Val Ala Ile 
1               5                   10                  15      


Tyr Asn Tyr Asn Ala Ser Gln Asp Val Glu Leu Ser Leu Gln Ile Gly 
            20                  25                  30          


Asp Thr Val His Ile Leu Glu Met Tyr Glu Gly Trp Tyr Arg Gly Tyr 
        35                  40                  45              


Thr Leu Gln Asn Lys Ser Lys Lys Gly Ile Phe Pro Glu Thr Tyr Ile 
    50                  55                  60                  


His Leu Lys Glu Ala Thr Val Glu Asp Leu Gly Gln His Glu Thr Val 
65                  70                  75                  80  


Ile Pro Gly Glu Leu Pro Leu Val Gln Glu Leu Thr Ser Thr Leu Arg 
                85                  90                  95      


Glu Trp Ala Val Ile Trp Arg Lys Leu Tyr Val Asn Asn Lys Leu Thr 
            100                 105                 110         


Leu Phe Arg Gln Leu Gln Gln Met Thr Tyr Ser Leu Ile Glu Trp Arg 
        115                 120                 125             


Ser Gln Ile Leu Ser Gly Thr Leu Pro Lys Asp Glu Leu Ala Glu Leu 
    130                 135                 140                 


Lys Lys Lys Val Thr Ala Lys Ile Asp His Gly Asn Arg Met Leu Gly 
145                 150                 155                 160 


Leu Asp Leu Val Val Arg Asp Asp Asn Gly Asn Ile Leu Asp Pro Asp 
                165                 170                 175     


Glu Thr Ser Thr Ile Ala Leu Phe Lys Ala His Glu Val Ala Ser Lys 
            180                 185                 190         


Arg Ile Glu Glu Lys Ile Gln Glu Glu Lys Ser Ile Leu Gln Asn Leu 
        195                 200                 205             


Asp Leu Arg Gly Gln Ser Ile Phe Ser Thr Ile His Thr Tyr Gly Leu 
    210                 215                 220                 


Tyr Val Asn Phe Lys Asn Phe Val Cys Asn Ile Gly Glu Asp Ala Glu 
225                 230                 235                 240 


Leu Phe Met Ala Leu Tyr Asp Pro Asp Gln Ser Thr Phe Ile Ser Glu 
                245                 250                 255     


Asn Tyr Leu Ile Arg Trp Gly Ser Asn Gly Met Pro Lys Glu Ile Glu 
            260                 265                 270         


Lys Leu Asn Asn Leu Gln Ala Val Phe Thr Asp Leu Ser Ser Met Asp 
        275                 280                 285             


Leu Ile Arg Pro Arg Val Ser Leu Val Cys Gln Ile Val Arg Val Gly 
    290                 295                 300                 


His Met Glu Leu Lys Glu Gly Lys Lys His Thr Cys Gly Leu Arg Arg 
305                 310                 315                 320 


Pro Phe Gly Val Ala Val Met Asp Ile Thr Asp Ile Ile His Gly Lys 
                325                 330                 335     


Val Asp Asp Glu Glu Lys Gln His Phe Ile Pro Phe Gln Gln Ile Ala 
            340                 345                 350         


Met Glu Thr Tyr Ile Arg Gln Arg Gln Leu Ile Met Ser Pro Leu Ile 
        355                 360                 365             


Thr Ser His Val Ile Gly Glu Asn Glu Pro Leu Thr Ser Val Leu Asn 
    370                 375                 380                 


Lys Val Ile Ala Ala Lys Glu Val Asn His Lys Gly Gln Gly Leu Trp 
385                 390                 395                 400 


Val Ser Leu Lys Leu Leu Pro Gly Asp Leu Thr Gln Val Gln Lys Asn 
                405                 410                 415     


Phe Ser His Leu Val Asp Arg Ser Thr Ala Ile Ala Arg Lys Met Gly 
            420                 425                 430         


Phe Pro Glu Ile Ile Leu Pro Gly Asp Val Arg Asn Asp Ile Tyr Val 
        435                 440                 445             


Thr Leu Ile His Gly Glu Phe Asp Lys Gly Lys Lys Lys Thr Pro Lys 
    450                 455                 460                 


Asn Val Glu Val Thr Met Ser Val His Asp Glu Glu Gly Lys Leu Leu 
465                 470                 475                 480 


Glu Lys Ala Ile His Pro Gly Ala Gly Tyr Glu Gly Ile Ser Glu Tyr 
                485                 490                 495     


Lys Ser Val Val Tyr Tyr Gln Val Lys Gln Pro Cys Trp Tyr Glu Thr 
            500                 505                 510         


Val Lys Val Ser Ile Ala Ile Glu Glu Val Thr Arg Cys His Ile Arg 
        515                 520                 525             


Phe Thr Phe Arg His Arg Ser Ser Gln Glu Thr Arg Asp Lys Ser Glu 
    530                 535                 540                 


Arg Ala Phe Gly Val Ala Phe Val Lys Leu Met Asn Pro Asp Gly Thr 
545                 550                 555                 560 


Thr Leu Gln Asp Gly Arg His Asp Leu Val Val Tyr Lys Gly Asp Asn 
                565                 570                 575     


Lys Lys Met Glu Asp Ala Lys Phe Tyr Leu Thr Leu Pro Gly Thr Lys 
            580                 585                 590         


Met Glu Met Glu Glu Lys Glu Leu Gln Ala Ser Lys Asn Leu Val Thr 
        595                 600                 605             


Phe Thr Pro Ser Lys Asp Ser Thr Lys Asp Ser Phe Gln Ile Ala Thr 
    610                 615                 620                 


Leu Ile Cys Ser Thr Lys Leu Thr Gln Asn Val Asp Leu Leu Gly Leu 
625                 630                 635                 640 


Leu Asn Trp Arg Ser Asn Ser Gln Asn Ile Lys His Asn Leu Lys Lys 
                645                 650                 655     


Leu Met Glu Val Asp Gly Gly Glu Ile Val Lys Phe Leu Gln Asp Thr 
            660                 665                 670         


Leu Asp Ala Leu Phe Asn Ile Met Met Glu Met Ser Asp Ser Glu Thr 
        675                 680                 685             


Tyr Asp Phe Leu Val Phe Asp Ala Leu Val Phe Ile Ile Ser Leu Ile 
    690                 695                 700                 


Gly Asp Ile Lys Phe Gln His Phe Asn Pro Val Leu Glu Thr Tyr Ile 
705                 710                 715                 720 


Tyr Lys His Phe Ser Ala Thr Leu Ala Tyr Val Lys Leu Ser Lys Val 
                725                 730                 735     


Leu Asn Phe Tyr Val Ala Asn Ala Asp Asp Ser Ser Lys Thr Glu Leu 
            740                 745                 750         


Leu Phe Ala Ala Leu Lys Ala Leu Lys Tyr Leu Phe Arg Phe Ile Ile 
        755                 760                 765             


Gln Ser Arg Val Leu Tyr Leu Arg Phe Tyr Gly Gln Ser Lys Asp Gly 
    770                 775                 780                 


Asp Glu Phe Asn Asn Ser Ile Arg Gln Leu Phe Leu Ala Phe Asn Met 
785                 790                 795                 800 


Leu Met Asp Arg Pro Leu Glu Glu Ala Val Lys Ile Lys Gly Ala Ala 
                805                 810                 815     


Leu Lys Tyr Leu Pro Ser Ile Ile Asn Asp Val Lys Leu Val Phe Asp 
            820                 825                 830         


Pro Val Glu Leu Ser Val Leu Phe Cys Lys Phe Ile Gln Ser Ile Pro 
        835                 840                 845             


Asp Asn Gln Leu Val Arg Gln Lys Leu Asn Cys Met Thr Lys Ile Val 
    850                 855                 860                 


Glu Ser Thr Leu Phe Arg Gln Ser Glu Cys Arg Glu Val Leu Leu Pro 
865                 870                 875                 880 


Leu Leu Thr Asp Gln Leu Ser Gly Gln Leu Asp Asp Asn Ser Asn Lys 
                885                 890                 895     


Pro Asp His Glu Ala Ser Ser Gln Leu Leu Ser Asn Ile Leu Glu Val 
            900                 905                 910         


Leu Asp Arg Lys Asp Val Gly Ala Thr Ala Val His Ile Gln Leu Ile 
        915                 920                 925             


Met Glu Arg Leu Leu Arg Arg Ile Asn Arg Thr Val Ile Gly Met Asn 
    930                 935                 940                 


Arg Gln Ser Pro His Ile Gly Ser Phe Val Ala Cys Met Ile Ala Leu 
945                 950                 955                 960 


Leu Gln Gln Met Asp Asp Ser His Tyr Ser His Tyr Ile Ser Thr Phe 
                965                 970                 975     


Lys Thr Arg Gln Asp Ile Ile Asp Phe Leu Met Glu Thr Phe Ile Met 
            980                 985                 990         


Phe Lys Asp Leu Ile Gly Lys Asn  Val Tyr Ala Lys Asp  Trp Met Val 
        995                 1000                 1005             


Met Asn  Met Thr Gln Asn Arg  Val Phe Leu Arg Ala  Ile Asn Gln 
    1010                 1015                 1020             


Phe Ala  Glu Val Leu Thr Arg  Phe Phe Met Asp Gln  Ala Ser Phe 
    1025                 1030                 1035             


Glu Leu  Gln Leu Trp Asn Asn  Tyr Phe His Leu Ala  Val Ala Phe 
    1040                 1045                 1050             


Leu Thr  His Glu Ser Leu Gln  Leu Glu Thr Phe Ser  Gln Ala Lys 
    1055                 1060                 1065             


Arg Asn  Lys Ile Val Lys Lys  Tyr Gly Asp Met Arg  Lys Glu Ile 
    1070                 1075                 1080             


Gly Phe  Arg Ile Arg Asp Met  Trp Tyr Asn Leu Gly  Pro His Lys 
    1085                 1090                 1095             


Ile Lys  Phe Ile Pro Ser Met  Val Gly Pro Ile Leu  Glu Val Thr 
    1100                 1105                 1110             


Leu Thr  Pro Glu Val Glu Leu  Arg Lys Ala Thr Ile  Pro Ile Phe 
    1115                 1120                 1125             


Phe Asp  Met Met Gln Cys Glu  Phe Asn Phe Ser Gly  Asn Gly Asn 
    1130                 1135                 1140             


Phe His  Met Phe Glu Asn Glu  Leu Ile Thr Lys Leu  Asp Gln Glu 
    1145                 1150                 1155             


Val Glu  Gly Gly Arg Gly Asp  Glu Gln Tyr Lys Val  Leu Leu Glu 
    1160                 1165                 1170             


Lys Leu  Leu Leu Glu His Cys  Arg Lys His Lys Tyr  Leu Ser Ser 
    1175                 1180                 1185             


Ser Gly  Glu Val Phe Ala Leu  Leu Val Ser Ser Leu  Leu Glu Asn 
    1190                 1195                 1200             


Leu Leu  Asp Tyr Arg Thr Ile  Ile Met Gln Asp Glu  Ser Lys Glu 
    1205                 1210                 1215             


Asn Arg  Met Ser Cys Thr Val  Asn Val Leu Asn Phe  Tyr Lys Glu 
    1220                 1225                 1230             


Lys Lys  Arg Glu Asp Ile Tyr  Ile Arg Tyr Leu Tyr  Lys Leu Arg 
    1235                 1240                 1245             


Asp Leu  His Arg Asp Cys Glu  Asn Tyr Thr Glu Ala  Ala Tyr Thr 
    1250                 1255                 1260             


Leu Leu  Leu His Ala Glu Leu  Leu Gln Trp Ser Asp  Lys Pro Cys 
    1265                 1270                 1275             


Val Pro  His Leu Leu Gln Lys  Asp Ser Tyr Tyr Val  Tyr Thr Gln 
    1280                 1285                 1290             


Gln Glu  Leu Lys Glu Lys Leu  Tyr Gln Glu Ile Ile  Ser Tyr Phe 
    1295                 1300                 1305             


Asp Lys  Gly Lys Met Trp Glu  Lys Ala Ile Lys Leu  Ser Lys Glu 
    1310                 1315                 1320             


Leu Ala  Glu Thr Tyr Glu Ser  Lys Val Phe Asp Tyr  Glu Gly Leu 
    1325                 1330                 1335             


Gly Asn  Leu Leu Lys Lys Arg  Ala Ser Phe Tyr Glu  Asn Ile Ile 
    1340                 1345                 1350             


Lys Ala  Met Arg Pro Gln Pro  Glu Tyr Phe Ala Val  Gly Tyr Tyr 
    1355                 1360                 1365             


Gly Gln  Gly Phe Pro Ser Phe  Leu Arg Asn Lys Ile  Phe Ile Tyr 
    1370                 1375                 1380             


Arg Gly  Lys Glu Tyr Glu Arg  Arg Glu Asp Phe Ser  Leu Arg Leu 
    1385                 1390                 1395             


Leu Thr  Gln Phe Pro Asn Ala  Glu Lys Met Thr Ser  Thr Thr Pro 
    1400                 1405                 1410             


Pro Gly  Glu Asp Ile Lys Ser  Ser Pro Lys Gln Tyr  Met Gln Cys 
    1415                 1420                 1425             


Phe Thr  Val Lys Pro Val Met  Ser Leu Pro Pro Ser  Tyr Lys Asp 
    1430                 1435                 1440             


Lys Pro  Val Pro Glu Gln Ile  Leu Asn Tyr Tyr Arg  Ala Asn Glu 
    1445                 1450                 1455             


Val Gln  Gln Phe Arg Tyr Ser  Arg Pro Phe Arg Lys  Gly Glu Lys 
    1460                 1465                 1470             


Asp Pro  Asp Asn Glu Phe Ala  Thr Met Trp Ile Glu  Arg Thr Thr 
    1475                 1480                 1485             


Tyr Thr  Thr Ala Tyr Thr Phe  Pro Gly Ile Leu Lys  Trp Phe Glu 
    1490                 1495                 1500             


Val Lys  Gln Ile Ser Thr Glu  Glu Ile Ser Pro Leu  Glu Asn Ala 
    1505                 1510                 1515             


Ile Glu  Thr Met Glu Leu Thr  Asn Glu Arg Ile Ser  Asn Cys Val 
    1520                 1525                 1530             


Gln Gln  His Ala Trp Asp Arg  Ser Leu Ser Val His  Pro Leu Ser 
    1535                 1540                 1545             


Met Leu  Leu Ser Gly Ile Val  Asp Pro Ala Val Met  Gly Gly Phe 
    1550                 1555                 1560             


Ser Asn  Tyr Glu Lys Ala Phe  Phe Thr Glu Lys Tyr  Leu Gln Glu 
    1565                 1570                 1575             


His Pro  Glu Asp Gln Glu Lys  Val Glu Leu Leu Lys  Arg Leu Ile 
    1580                 1585                 1590             


Ala Leu  Gln Met Pro Leu Leu  Thr Glu Gly Ile Arg  Ile His Gly 
    1595                 1600                 1605             


Glu Lys  Leu Thr Glu Gln Leu  Lys Pro Leu His Glu  Arg Leu Ser 
    1610                 1615                 1620             


Ser Cys  Phe Arg Glu Leu Lys  Glu Lys Val Glu Lys  His Tyr Gly 
    1625                 1630                 1635             


Val Ile  Thr Leu Pro Pro Asn  Leu Thr Glu Arg Lys  Gln Ser Arg 
    1640                 1645                 1650             


Thr Gly  Ser Ile Val Leu Pro  Tyr Ile Met Ser Ser  Thr Leu Arg 
    1655                 1660                 1665             


Arg Leu  Ser Ile Thr Ser Val  Thr Ser Ser Val Val  Ser Thr Ser 
    1670                 1675                 1680             


Ser Asn  Ser Ser Asp Asn Ala  Pro Ser Arg Pro Gly  Ser Asp Gly 
    1685                 1690                 1695             


Ser Ile  Leu Glu Pro Leu Leu  Glu Arg Arg Ala Ser  Ser Gly Ala 
    1700                 1705                 1710             


Arg Val  Glu Asp Leu Ser Leu  Arg Glu Glu Asn Ser  Glu Asn Arg 
    1715                 1720                 1725             


Ile Ser  Lys Phe Lys Arg Lys  Asp Trp Ser Leu Ser  Lys Ser Gln 
    1730                 1735                 1740             


Val Ile  Ala Glu Lys Ala Pro  Glu Pro Asp Leu Met  Ser Pro Thr 
    1745                 1750                 1755             


Arg Lys  Ala Gln Arg Pro Lys  Ser Leu Gln Leu Met  Asp Asn Arg 
    1760                 1765                 1770             


Leu Ser  Pro Phe His Gly Ser  Ser Pro Pro Gln Ser  Thr Pro Leu 
    1775                 1780                 1785             


Ser Pro  Pro Pro Leu Thr Pro  Lys Ala Thr Arg Thr  Leu Ser Ser 
    1790                 1795                 1800             


Pro Ser  Leu Gln Thr Asp Gly  Ile Ala Ala Thr Pro  Val Pro Pro 
    1805                 1810                 1815             


Pro Pro  Pro Pro Lys Ser Lys  Pro Tyr Glu Gly Ser  Gln Arg Asn 
    1820                 1825                 1830             


Ser Thr  Glu Leu Ala Pro Pro  Leu Pro Val Arg Arg  Glu Ala Lys 
    1835                 1840                 1845             


Ala Pro  Pro Pro Pro Pro Pro  Lys Ala Arg Lys Ser  Gly Ile Pro 
    1850                 1855                 1860             


Thr Ser  Glu Pro Gly Ser Gln  
    1865                 1870 


<210>  3207
<211>  2047
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK6__Homo_sapiens__NP_065863

<400>  3207

Met Ala Ala Ser Glu Arg Arg Ala Phe Ala His Lys Ile Asn Arg Thr 
1               5                   10                  15      


Val Ala Ala Glu Val Arg Lys Gln Val Ser Arg Glu Arg Ser Gly Ser 
            20                  25                  30          


Pro His Ser Ser Arg Arg Cys Ser Ser Ser Leu Gly Val Pro Leu Thr 
        35                  40                  45              


Glu Val Val Glu Pro Leu Asp Phe Glu Asp Val Leu Leu Ser Arg Pro 
    50                  55                  60                  


Pro Asp Ala Glu Pro Gly Pro Leu Arg Asp Leu Val Glu Phe Pro Ala 
65                  70                  75                  80  


Asp Asp Leu Glu Leu Leu Leu Gln Pro Arg Glu Cys Arg Thr Thr Glu 
                85                  90                  95      


Pro Gly Ile Pro Lys Asp Glu Lys Leu Asp Ala Gln Val Arg Ala Ala 
            100                 105                 110         


Val Glu Met Tyr Ile Glu Asp Trp Val Ile Val His Arg Arg Tyr Gln 
        115                 120                 125             


Tyr Leu Ser Ala Ala Tyr Ser Pro Val Thr Thr Asp Thr Gln Arg Glu 
    130                 135                 140                 


Arg Gln Lys Gly Leu Pro Arg Gln Val Phe Glu Gln Asp Ala Ser Gly 
145                 150                 155                 160 


Asp Glu Arg Ser Gly Pro Glu Asp Ser Asn Asp Ser Arg Arg Gly Ser 
                165                 170                 175     


Gly Ser Pro Glu Asp Thr Pro Arg Ser Ser Gly Ala Ser Ser Ile Phe 
            180                 185                 190         


Asp Leu Arg Asn Leu Ala Ala Asp Ser Leu Leu Pro Ser Leu Leu Glu 
        195                 200                 205             


Arg Ala Ala Pro Glu Asp Val Asp Arg Arg Asn Glu Thr Leu Arg Arg 
    210                 215                 220                 


Gln His Arg Pro Pro Ala Leu Leu Thr Leu Tyr Pro Ala Pro Asp Glu 
225                 230                 235                 240 


Asp Glu Ala Val Glu Arg Cys Ser Arg Pro Glu Pro Pro Arg Glu His 
                245                 250                 255     


Phe Gly Gln Arg Ile Leu Val Lys Cys Leu Ser Leu Lys Phe Glu Ile 
            260                 265                 270         


Glu Ile Glu Pro Ile Phe Gly Ile Leu Ala Leu Tyr Asp Val Arg Glu 
        275                 280                 285             


Lys Lys Lys Ile Ser Glu Asn Phe Tyr Phe Asp Leu Asn Ser Asp Ser 
    290                 295                 300                 


Met Lys Gly Leu Leu Arg Ala His Gly Thr His Pro Ala Ile Ser Thr 
305                 310                 315                 320 


Leu Ala Arg Ser Ala Ile Phe Ser Val Thr Tyr Pro Ser Pro Asp Ile 
                325                 330                 335     


Phe Leu Val Ile Lys Leu Glu Lys Val Leu Gln Gln Gly Asp Ile Ser 
            340                 345                 350         


Glu Cys Cys Glu Pro Tyr Met Val Leu Lys Glu Val Asp Thr Ala Lys 
        355                 360                 365             


Asn Lys Glu Lys Leu Glu Lys Leu Arg Leu Ala Ala Glu Gln Phe Cys 
    370                 375                 380                 


Thr Arg Leu Gly Arg Tyr Arg Met Pro Phe Ala Trp Thr Ala Val His 
385                 390                 395                 400 


Leu Ala Asn Ile Val Ser Ser Ala Gly Gln Leu Asp Arg Asp Ser Asp 
                405                 410                 415     


Ser Glu Gly Glu Arg Arg Pro Ala Trp Thr Asp Arg Arg Arg Arg Gly 
            420                 425                 430         


Pro Gln Asp Arg Ala Ser Ser Gly Asp Asp Ala Cys Ser Phe Ser Gly 
        435                 440                 445             


Phe Arg Pro Ala Thr Leu Thr Val Thr Asn Phe Phe Lys Gln Glu Ala 
    450                 455                 460                 


Glu Arg Leu Ser Asp Glu Asp Leu Phe Lys Phe Leu Ala Asp Met Arg 
465                 470                 475                 480 


Arg Pro Ser Ser Leu Leu Arg Arg Leu Arg Pro Val Thr Ala Gln Leu 
                485                 490                 495     


Lys Ile Asp Ile Ser Pro Ala Pro Glu Asn Pro His Phe Cys Leu Ser 
            500                 505                 510         


Pro Glu Leu Leu His Ile Lys Pro Tyr Pro Asp Pro Arg Gly Arg Pro 
        515                 520                 525             


Thr Lys Glu Ile Leu Glu Phe Pro Ala Arg Glu Val Tyr Ala Pro His 
    530                 535                 540                 


Thr Ser Tyr Arg Asn Leu Leu Tyr Val Tyr Pro His Ser Leu Asn Phe 
545                 550                 555                 560 


Ser Ser Arg Gln Gly Ser Val Arg Asn Leu Ala Val Arg Val Gln Tyr 
                565                 570                 575     


Met Thr Gly Glu Asp Pro Ser Gln Ala Leu Pro Val Ile Phe Gly Lys 
            580                 585                 590         


Ser Ser Cys Ser Glu Phe Thr Arg Glu Ala Phe Thr Pro Val Val Tyr 
        595                 600                 605             


His Asn Lys Ser Pro Glu Phe Tyr Glu Glu Phe Lys Leu His Leu Pro 
    610                 615                 620                 


Ala Cys Val Thr Glu Asn His His Leu Leu Phe Thr Phe Tyr His Val 
625                 630                 635                 640 


Ser Cys Gln Pro Arg Pro Gly Thr Ala Leu Glu Thr Pro Val Gly Phe 
                645                 650                 655     


Thr Trp Ile Pro Leu Leu Gln His Gly Arg Leu Arg Thr Gly Pro Phe 
            660                 665                 670         


Cys Leu Pro Val Ser Val Asp Gln Pro Pro Pro Ser Tyr Ser Val Leu 
        675                 680                 685             


Thr Pro Asp Val Ala Leu Pro Gly Met Arg Trp Val Asp Gly His Lys 
    690                 695                 700                 


Gly Val Phe Ser Val Glu Leu Thr Ala Val Ser Ser Val His Pro Gln 
705                 710                 715                 720 


Asp Pro Tyr Leu Asp Lys Phe Phe Thr Leu Val His Val Leu Glu Glu 
                725                 730                 735     


Gly Ala Phe Pro Phe Arg Leu Lys Asp Thr Val Leu Ser Glu Gly Asn 
            740                 745                 750         


Val Glu Gln Glu Leu Arg Ala Ser Leu Ala Ala Leu Arg Leu Ala Ser 
        755                 760                 765             


Pro Glu Pro Leu Val Ala Phe Ser His His Val Leu Asp Lys Leu Val 
    770                 775                 780                 


Arg Leu Val Ile Arg Pro Pro Ile Ile Ser Gly Gln Ile Val Asn Leu 
785                 790                 795                 800 


Gly Arg Gly Ala Phe Glu Ala Met Ala His Val Val Ser Leu Val His 
                805                 810                 815     


Arg Ser Leu Glu Ala Ala Gln Asp Ala Arg Gly His Cys Pro Gln Leu 
            820                 825                 830         


Ala Ala Tyr Val His Tyr Ala Phe Arg Leu Pro Gly Thr Glu Pro Ser 
        835                 840                 845             


Leu Pro Asp Gly Ala Pro Pro Val Thr Val Gln Ala Ala Thr Leu Ala 
    850                 855                 860                 


Arg Gly Ser Gly Arg Pro Ala Ser Leu Tyr Leu Ala Arg Ser Lys Ser 
865                 870                 875                 880 


Ile Ser Ser Ser Asn Pro Asp Leu Ala Val Ala Pro Gly Ser Val Asp 
                885                 890                 895     


Asp Glu Val Ser Arg Ile Leu Ala Ser Lys Leu Leu His Glu Glu Leu 
            900                 905                 910         


Ala Leu Gln Trp Val Val Ser Ser Ser Ala Val Arg Glu Ala Ile Leu 
        915                 920                 925             


Gln His Ala Trp Phe Phe Phe Gln Leu Met Val Lys Ser Met Ala Leu 
    930                 935                 940                 


His Leu Leu Leu Gly Gln Arg Leu Asp Thr Pro Arg Lys Leu Arg Phe 
945                 950                 955                 960 


Pro Gly Arg Phe Leu Asp Asp Ile Thr Ala Leu Val Gly Ser Val Gly 
                965                 970                 975     


Leu Glu Val Ile Thr Arg Val His Lys Asp Val Glu Leu Ala Glu His 
            980                 985                 990         


Leu Asn Ala Ser Leu Ala Phe Phe  Leu Ser Asp Leu Leu  Ser Leu Val 
        995                 1000                 1005             


Asp Arg  Gly Phe Val Phe Ser  Leu Val Arg Ala His  Tyr Lys Gln 
    1010                 1015                 1020             


Val Ala  Thr Arg Leu Gln Ser  Ser Pro Asn Pro Ala  Ala Leu Leu 
    1025                 1030                 1035             


Thr Leu  Arg Met Glu Phe Thr  Arg Ile Leu Cys Ser  His Glu His 
    1040                 1045                 1050             


Tyr Val  Thr Leu Asn Leu Pro  Cys Cys Pro Leu Ser  Pro Pro Ala 
    1055                 1060                 1065             


Ser Pro  Ser Pro Ser Val Ser  Ser Thr Thr Ser Gln  Ser Ser Thr 
    1070                 1075                 1080             


Phe Ser  Ser Gln Ala Pro Asp  Pro Lys Val Thr Ser  Met Phe Glu 
    1085                 1090                 1095             


Leu Ser  Gly Pro Phe Arg Gln  Gln His Phe Leu Ala  Gly Leu Leu 
    1100                 1105                 1110             


Leu Thr  Glu Leu Ala Leu Ala  Leu Glu Pro Glu Ala  Glu Gly Ala 
    1115                 1120                 1125             


Phe Leu  Leu His Lys Lys Ala  Ile Ser Ala Val His  Ser Leu Leu 
    1130                 1135                 1140             


Cys Gly  His Asp Thr Asp Pro  Arg Tyr Ala Glu Ala  Thr Val Lys 
    1145                 1150                 1155             


Ala Arg  Val Ala Glu Leu Tyr  Leu Pro Leu Leu Ser  Ile Ala Arg 
    1160                 1165                 1170             


Asp Thr  Leu Pro Arg Leu His  Asp Phe Ala Glu Gly  Pro Gly Gln 
    1175                 1180                 1185             


Arg Ser  Arg Leu Ala Ser Met  Leu Asp Ser Asp Thr  Glu Gly Glu 
    1190                 1195                 1200             


Gly Asp  Ile Ala Gly Thr Ile  Asn Pro Ser Val Ala  Met Ala Ile 
    1205                 1210                 1215             


Ala Gly  Gly Pro Leu Ala Pro  Gly Ser Arg Ala Ser  Ile Ser Gln 
    1220                 1225                 1230             


Gly Pro  Pro Thr Ala Ser Arg  Ala Gly Cys Ala Leu  Ser Ala Glu 
    1235                 1240                 1245             


Ser Ser  Arg Thr Leu Leu Ala  Cys Val Leu Trp Val  Leu Lys Asn 
    1250                 1255                 1260             


Thr Glu  Pro Ala Leu Leu Gln  Arg Trp Ala Thr Asp  Leu Thr Leu 
    1265                 1270                 1275             


Pro Gln  Leu Gly Arg Leu Leu  Asp Leu Leu Tyr Leu  Cys Leu Ala 
    1280                 1285                 1290             


Ala Phe  Glu Tyr Lys Gly Lys  Lys Ala Phe Glu Arg  Ile Asn Ser 
    1295                 1300                 1305             


Leu Thr  Phe Lys Lys Ser Leu  Asp Met Lys Ala Arg  Leu Glu Glu 
    1310                 1315                 1320             


Ala Ile  Leu Gly Thr Ile Gly  Ala Arg Gln Glu Met  Val Arg Arg 
    1325                 1330                 1335             


Ser Arg  Glu Arg Ser Pro Phe  Gly Asn Pro Glu Asn  Val Arg Trp 
    1340                 1345                 1350             


Arg Lys  Ser Val Thr His Trp  Lys Gln Thr Ser Asp  Arg Val Asp 
    1355                 1360                 1365             


Lys Thr  Lys Asp Glu Met Glu  His Glu Ala Leu Val  Glu Gly Asn 
    1370                 1375                 1380             


Leu Ala  Thr Glu Ala Ser Leu  Val Val Leu Asp Thr  Leu Glu Ile 
    1385                 1390                 1395             


Ile Val  Gln Thr Val Met Leu  Ser Glu Ala Arg Glu  Ser Val Leu 
    1400                 1405                 1410             


Gly Ala  Val Leu Lys Val Val  Leu Tyr Ser Leu Gly  Ser Ala Gln 
    1415                 1420                 1425             


Ser Ala  Leu Phe Leu Gln His  Gly Leu Ala Thr Gln  Arg Ala Leu 
    1430                 1435                 1440             


Val Ser  Lys Phe Pro Glu Leu  Leu Phe Glu Glu Asp  Thr Glu Leu 
    1445                 1450                 1455             


Cys Ala  Asp Leu Cys Leu Arg  Leu Leu Arg His Cys  Gly Ser Arg 
    1460                 1465                 1470             


Ile Ser  Thr Ile Arg Thr His  Ala Ser Ala Ser Leu  Tyr Leu Leu 
    1475                 1480                 1485             


Met Arg  Gln Asn Phe Glu Ile  Gly His Asn Phe Ala  Arg Val Lys 
    1490                 1495                 1500             


Met Gln  Val Thr Met Ser Leu  Ser Ser Leu Val Gly  Thr Thr Gln 
    1505                 1510                 1515             


Asn Phe  Ser Glu Glu His Leu  Arg Arg Ser Leu Lys  Thr Ile Leu 
    1520                 1525                 1530             


Thr Tyr  Ala Glu Glu Asp Met  Gly Leu Arg Asp Ser  Thr Phe Ala 
    1535                 1540                 1545             


Glu Gln  Val Gln Asp Leu Met  Phe Asn Leu His Met  Ile Leu Thr 
    1550                 1555                 1560             


Asp Thr  Val Lys Met Lys Glu  His Gln Glu Asp Pro  Glu Met Leu 
    1565                 1570                 1575             


Ile Asp  Leu Met Tyr Arg Ile  Ala Arg Gly Tyr Gln  Gly Ser Pro 
    1580                 1585                 1590             


Asp Leu  Arg Leu Thr Trp Leu  Gln Asn Met Ala Gly  Lys His Ala 
    1595                 1600                 1605             


Glu Leu  Gly Asn His Ala Glu  Ala Ala Gln Cys Met  Val His Ala 
    1610                 1615                 1620             


Ala Ala  Leu Val Ala Glu Tyr  Leu Ala Leu Leu Glu  Asp His Arg 
    1625                 1630                 1635             


His Leu  Pro Val Gly Cys Val  Ser Phe Gln Asn Ile  Ser Ser Asn 
    1640                 1645                 1650             


Val Leu  Glu Glu Ser Ala Ile  Ser Asp Asp Ile Leu  Ser Pro Asp 
    1655                 1660                 1665             


Glu Glu  Gly Phe Cys Ser Gly  Lys His Phe Thr Glu  Leu Gly Leu 
    1670                 1675                 1680             


Val Gly  Leu Leu Glu Gln Ala  Ala Gly Tyr Phe Thr  Met Gly Gly 
    1685                 1690                 1695             


Leu Tyr  Glu Ala Val Asn Glu  Val Tyr Lys Asn Leu  Ile Pro Ile 
    1700                 1705                 1710             


Leu Glu  Ala His Arg Asp Tyr  Lys Lys Leu Ala Ala  Val His Gly 
    1715                 1720                 1725             


Lys Leu  Gln Glu Ala Phe Thr  Lys Ile Met His Gln  Ser Ser Gly 
    1730                 1735                 1740             


Trp Glu  Arg Val Phe Gly Thr  Tyr Phe Arg Val Gly  Phe Tyr Gly 
    1745                 1750                 1755             


Ala His  Phe Gly Asp Leu Asp  Glu Gln Glu Phe Val  Tyr Lys Glu 
    1760                 1765                 1770             


Pro Ser  Ile Thr Lys Leu Ala  Glu Ile Ser His Arg  Leu Glu Glu 
    1775                 1780                 1785             


Phe Tyr  Thr Glu Arg Phe Gly  Asp Asp Val Val Glu  Ile Ile Lys 
    1790                 1795                 1800             


Asp Ser  Asn Pro Val Asp Lys  Ser Lys Leu Asp Ser  Gln Lys Ala 
    1805                 1810                 1815             


Tyr Ile  Gln Ile Thr Tyr Val  Glu Pro Tyr Phe Asp  Thr Tyr Glu 
    1820                 1825                 1830             


Leu Lys  Asp Arg Val Thr Tyr  Phe Asp Arg Asn Tyr  Gly Leu Arg 
    1835                 1840                 1845             


Thr Phe  Leu Phe Cys Thr Pro  Phe Thr Pro Asp Gly  Arg Ala His 
    1850                 1855                 1860             


Gly Glu  Leu Pro Glu Gln His  Lys Arg Lys Thr Leu  Leu Ser Thr 
    1865                 1870                 1875             


Asp His  Ala Phe Pro Tyr Ile  Lys Thr Arg Ile Arg  Val Cys His 
    1880                 1885                 1890             


Arg Glu  Glu Thr Val Leu Thr  Pro Val Glu Val Ala  Ile Glu Asp 
    1895                 1900                 1905             


Met Gln  Lys Lys Thr Arg Glu  Leu Ala Phe Ala Thr  Glu Gln Asp 
    1910                 1915                 1920             


Pro Pro  Asp Ala Lys Met Leu  Gln Met Val Leu Gln  Gly Ser Val 
    1925                 1930                 1935             


Gly Pro  Thr Val Asn Gln Gly  Pro Leu Glu Val Ala  Gln Val Phe 
    1940                 1945                 1950             


Leu Ala  Glu Ile Pro Glu Asp  Pro Lys Leu Phe Arg  His His Asn 
    1955                 1960                 1965             


Lys Leu  Arg Leu Cys Phe Lys  Asp Phe Cys Lys Lys  Cys Glu Asp 
    1970                 1975                 1980             


Ala Leu  Arg Lys Asn Lys Ala  Leu Ile Gly Pro Asp  Gln Lys Glu 
    1985                 1990                 1995             


Tyr His  Arg Glu Leu Glu Arg  Asn Tyr Cys Arg Leu  Arg Glu Ala 
    2000                 2005                 2010             


Leu Gln  Pro Leu Leu Thr Gln  Arg Leu Pro Gln Leu  Met Ala Pro 
    2015                 2020                 2025             


Thr Pro  Pro Gly Leu Arg Asn  Ser Leu Asn Arg Ala  Ser Phe Arg 
    2030                 2035                 2040             


Lys Ala  Asp Leu 
    2045         


<210>  3208
<211>  2140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK7__Homo_sapiens__XP_011540628

<400>  3208

Met Ala Glu Arg Arg Ala Phe Ala Gln Lys Ile Ser Arg Thr Val Ala 
1               5                   10                  15      


Ala Glu Val Arg Lys Gln Ile Ser Gly Gln Tyr Ser Gly Ser Pro Gln 
            20                  25                  30          


Leu Leu Lys Asn Leu Asn Ile Val Gly Asn Ile Ser His His Thr Thr 
        35                  40                  45              


Val Pro Leu Thr Glu Ala Val Asp Pro Val Asp Leu Glu Asp Tyr Leu 
    50                  55                  60                  


Ile Thr His Pro Leu Ala Val Asp Ser Gly Pro Leu Arg Asp Leu Ile 
65                  70                  75                  80  


Glu Phe Pro Pro Asp Asp Ile Glu Val Val Tyr Ser Pro Arg Asp Cys 
                85                  90                  95      


Arg Thr Leu Val Ser Ala Val Pro Glu Glu Ser Glu Met Asp Pro His 
            100                 105                 110         


Val Arg Asp Cys Ile Arg Ser Tyr Thr Glu Asp Trp Ala Ile Val Ile 
        115                 120                 125             


Arg Lys Tyr His Lys Leu Gly Thr Gly Phe Asn Pro Asn Thr Leu Asp 
    130                 135                 140                 


Lys Gln Lys Glu Arg Gln Lys Gly Leu Pro Lys Gln Val Phe Glu Ser 
145                 150                 155                 160 


Asp Glu Ala Pro Asp Gly Asn Ser Tyr Gln Asp Asp Gln Asp Asp Leu 
                165                 170                 175     


Lys Arg Arg Ser Met Ser Ile Asp Asp Thr Pro Arg Gly Ser Trp Ala 
            180                 185                 190         


Cys Ser Ile Phe Asp Leu Lys Asn Ser Leu Pro Asp Ala Leu Leu Pro 
        195                 200                 205             


Asn Leu Leu Asp Arg Thr Pro Asn Glu Glu Ile Asp Arg Gln Asn Asp 
    210                 215                 220                 


Asp Gln Arg Lys Ser Asn Arg His Lys Glu Leu Phe Ala Leu His Pro 
225                 230                 235                 240 


Ser Pro Asp Glu Glu Glu Pro Ile Glu Arg Leu Ser Val Pro Asp Ile 
                245                 250                 255     


Pro Lys Glu His Phe Gly Gln Arg Leu Leu Val Lys Cys Leu Ser Leu 
            260                 265                 270         


Lys Phe Glu Ile Glu Ile Glu Pro Ile Phe Ala Ser Leu Ala Leu Tyr 
        275                 280                 285             


Asp Val Lys Glu Lys Lys Lys Ile Ser Glu Asn Phe Tyr Phe Asp Leu 
    290                 295                 300                 


Asn Ser Glu Gln Met Lys Gly Leu Leu Arg Pro His Val Pro Pro Ala 
305                 310                 315                 320 


Ala Ile Thr Thr Leu Ala Arg Ser Ala Ile Phe Ser Ile Thr Tyr Pro 
                325                 330                 335     


Ser Gln Asp Val Phe Leu Val Ile Lys Leu Glu Lys Val Leu Gln Gln 
            340                 345                 350         


Gly Asp Ile Gly Glu Cys Ala Glu Pro Tyr Met Ile Phe Lys Glu Ala 
        355                 360                 365             


Asp Ala Thr Lys Asn Lys Glu Lys Leu Glu Lys Leu Lys Ser Gln Ala 
    370                 375                 380                 


Asp Gln Phe Cys Gln Arg Leu Gly Lys Tyr Arg Met Pro Phe Ala Trp 
385                 390                 395                 400 


Thr Ala Ile His Leu Met Asn Ile Val Ser Ser Ala Gly Ser Leu Glu 
                405                 410                 415     


Arg Asp Ser Thr Glu Val Glu Ile Ser Thr Gly Glu Arg Lys Gly Ser 
            420                 425                 430         


Trp Ser Glu Arg Arg Asn Ser Ser Ile Val Gly Arg Arg Ser Leu Glu 
        435                 440                 445             


Arg Thr Thr Ser Gly Asp Asp Ala Cys Asn Leu Thr Ser Phe Arg Pro 
    450                 455                 460                 


Ala Thr Leu Thr Val Thr Asn Phe Phe Lys Gln Glu Gly Asp Arg Leu 
465                 470                 475                 480 


Ser Asp Glu Asp Leu Tyr Lys Phe Leu Ala Asp Met Arg Arg Pro Ser 
                485                 490                 495     


Ser Val Leu Arg Arg Leu Arg Pro Ile Thr Ala Gln Leu Lys Ile Asp 
            500                 505                 510         


Ile Ser Pro Ala Pro Glu Asn Pro His Tyr Cys Leu Thr Pro Glu Leu 
        515                 520                 525             


Leu Gln Val Lys Leu Tyr Pro Asp Ser Arg Val Arg Pro Thr Arg Glu 
    530                 535                 540                 


Ile Leu Glu Phe Pro Ala Arg Asp Val Tyr Val Pro Asn Thr Thr Tyr 
545                 550                 555                 560 


Arg Asn Leu Leu Tyr Ile Tyr Pro Gln Ser Leu Asn Phe Ala Asn Arg 
                565                 570                 575     


Gln Gly Ser Ala Arg Asn Ile Thr Val Lys Val Gln Phe Met Tyr Gly 
            580                 585                 590         


Glu Asp Pro Ser Asn Ala Met Pro Val Ile Phe Gly Lys Ser Ser Cys 
        595                 600                 605             


Ser Glu Phe Ser Lys Glu Ala Tyr Thr Ala Val Val Tyr His Asn Arg 
    610                 615                 620                 


Ser Pro Asp Phe His Glu Glu Ile Lys Val Lys Leu Pro Ala Thr Leu 
625                 630                 635                 640 


Thr Asp His His His Leu Leu Phe Thr Phe Tyr His Val Ser Cys Gln 
                645                 650                 655     


Gln Lys Gln Asn Thr Pro Leu Glu Thr Pro Val Gly Tyr Thr Trp Ile 
            660                 665                 670         


Pro Met Leu Gln Asn Gly Arg Leu Lys Thr Gly Gln Phe Cys Leu Pro 
        675                 680                 685             


Val Ser Leu Glu Lys Pro Pro Gln Ala Tyr Ser Val Leu Ser Pro Glu 
    690                 695                 700                 


Val Pro Leu Pro Gly Met Lys Trp Val Asp Asn His Lys Gly Val Phe 
705                 710                 715                 720 


Asn Val Glu Val Val Ala Val Ser Ser Ile His Thr Gln Asp Pro Tyr 
                725                 730                 735     


Leu Asp Lys Phe Phe Ala Leu Val Asn Ala Leu Asp Glu His Leu Phe 
            740                 745                 750         


Pro Val Arg Ile Gly Asp Met Arg Ile Met Glu Asn Asn Leu Glu Asn 
        755                 760                 765             


Glu Leu Lys Ser Ser Ile Ser Ala Leu Asn Ser Ser Gln Leu Glu Pro 
    770                 775                 780                 


Val Val Arg Phe Leu His Leu Leu Leu Asp Lys Leu Ile Leu Leu Val 
785                 790                 795                 800 


Ile Arg Pro Pro Val Ile Ala Gly Gln Ile Val Asn Leu Gly Gln Ala 
                805                 810                 815     


Ser Phe Glu Ala Met Ala Ser Ile Ile Asn Arg Leu His Lys Asn Leu 
            820                 825                 830         


Glu Gly Asn His Asp Gln His Gly Arg Asn Ser Leu Leu Ala Ser Tyr 
        835                 840                 845             


Ile His Tyr Val Phe Arg Leu Pro Asn Thr Tyr Pro Asn Ser Ser Ser 
    850                 855                 860                 


Pro Gly Pro Gly Gly Leu Gly Gly Ser Val His Tyr Ala Thr Met Ala 
865                 870                 875                 880 


Arg Ser Ala Val Arg Pro Ala Ser Leu Asn Leu Asn Arg Ser Arg Ser 
                885                 890                 895     


Leu Ser Asn Ser Asn Pro Asp Ile Ser Gly Thr Pro Thr Ser Pro Asp 
            900                 905                 910         


Asp Glu Val Arg Ser Ile Ile Gly Ser Lys Gly Leu Asp Arg Ser Asn 
        915                 920                 925             


Ser Trp Val Asn Thr Gly Gly Pro Lys Ala Ala Pro Trp Gly Ser Asn 
    930                 935                 940                 


Pro Ser Pro Ser Ala Glu Ser Thr Gln Ala Met Asp Arg Ser Cys Asn 
945                 950                 955                 960 


Arg Met Ser Ser His Thr Glu Thr Ser Ser Phe Leu Gln Thr Leu Thr 
                965                 970                 975     


Gly Arg Leu Pro Thr Lys Lys Leu Phe His Glu Glu Leu Ala Leu Gln 
            980                 985                 990         


Trp Val Val Cys Ser Gly Ser Val  Arg Glu Ser Ala Leu  Gln Gln Ala 
        995                 1000                 1005             


Trp Phe  Phe Phe Glu Leu Met  Val Lys Ser Met Val  His His Leu 
    1010                 1015                 1020             


Tyr Phe  Asn Asp Lys Leu Glu  Ala Pro Arg Lys Ser  Arg Phe Pro 
    1025                 1030                 1035             


Glu Arg  Phe Met Asp Asp Ile  Ala Ala Leu Val Ser  Thr Ile Ala 
    1040                 1045                 1050             


Ser Asp  Ile Val Ser Arg Phe  Gln Lys Asp Thr Glu  Met Val Glu 
    1055                 1060                 1065             


Arg Leu  Asn Thr Ser Leu Ala  Phe Phe Leu Asn Asp  Leu Leu Ser 
    1070                 1075                 1080             


Val Met  Asp Arg Gly Phe Val  Phe Ser Leu Ile Lys  Ser Cys Tyr 
    1085                 1090                 1095             


Lys Gln  Val Ser Ser Lys Leu  Tyr Ser Leu Pro Asn  Pro Ser Val 
    1100                 1105                 1110             


Leu Val  Ser Leu Arg Leu Asp  Phe Leu Arg Ile Ile  Cys Ser His 
    1115                 1120                 1125             


Glu His  Tyr Val Thr Leu Asn  Leu Pro Cys Ser Leu  Leu Thr Pro 
    1130                 1135                 1140             


Pro Ala  Ser Pro Ser Pro Ser  Val Ser Ser Ala Thr  Ser Gln Ser 
    1145                 1150                 1155             


Ser Gly  Phe Ser Thr Asn Val  Gln Asp Gln Lys Ile  Ala Asn Met 
    1160                 1165                 1170             


Phe Glu  Leu Ser Val Pro Phe  Arg Gln Gln His Tyr  Leu Ala Gly 
    1175                 1180                 1185             


Leu Val  Leu Thr Glu Leu Ala  Val Ile Leu Asp Pro  Asp Ala Glu 
    1190                 1195                 1200             


Gly Leu  Phe Gly Leu His Lys  Lys Val Ile Asn Met  Val His Asn 
    1205                 1210                 1215             


Leu Leu  Ser Ser His Asp Ser  Asp Pro Arg Tyr Ser  Asp Pro Gln 
    1220                 1225                 1230             


Ile Lys  Ala Arg Val Ala Met  Leu Tyr Leu Pro Leu  Ile Gly Ile 
    1235                 1240                 1245             


Ile Met  Glu Thr Val Pro Gln  Leu Tyr Asp Phe Thr  Glu Thr His 
    1250                 1255                 1260             


Asn Gln  Arg Gly Arg Pro Ile  Cys Ile Ala Thr Asp  Asp Tyr Glu 
    1265                 1270                 1275             


Ser Glu  Ser Gly Ser Met Ile  Ser Gln Thr Val Ala  Met Ala Ile 
    1280                 1285                 1290             


Ala Gly  Thr Ser Val Pro Gln  Leu Thr Arg Pro Gly  Ser Phe Leu 
    1295                 1300                 1305             


Leu Thr  Ser Thr Ser Gly Arg  Gln His Thr Thr Phe  Ser Ala Glu 
    1310                 1315                 1320             


Ser Ser  Arg Ser Leu Leu Ile  Cys Leu Leu Trp Val  Leu Lys Asn 
    1325                 1330                 1335             


Ala Asp  Glu Thr Val Leu Gln  Lys Trp Phe Thr Asp  Leu Ser Val 
    1340                 1345                 1350             


Leu Gln  Leu Asn Arg Leu Leu  Asp Leu Leu Tyr Leu  Cys Val Ser 
    1355                 1360                 1365             


Cys Phe  Glu Tyr Lys Gly Lys  Lys Val Phe Glu Arg  Met Asn Ser 
    1370                 1375                 1380             


Leu Thr  Phe Lys Lys Ser Lys  Asp Met Arg Ala Lys  Leu Glu Glu 
    1385                 1390                 1395             


Ala Ile  Leu Gly Ser Ile Gly  Ala Arg Gln Glu Met  Val Arg Arg 
    1400                 1405                 1410             


Ser Arg  Gly Gln Leu Gly Thr  Tyr Thr Ile Ala Ser  Pro Pro Glu 
    1415                 1420                 1425             


Arg Ser  Pro Ser Gly Ser Ala  Phe Gly Ser Gln Glu  Asn Leu Arg 
    1430                 1435                 1440             


Trp Arg  Lys Asp Met Thr His  Trp Arg Gln Asn Thr  Glu Lys Leu 
    1445                 1450                 1455             


Asp Lys  Ser Arg Ala Glu Ile  Glu His Glu Ala Leu  Ile Asp Gly 
    1460                 1465                 1470             


Asn Leu  Ala Thr Glu Ala Asn  Leu Ile Ile Leu Asp  Thr Leu Glu 
    1475                 1480                 1485             


Ile Val  Val Gln Thr Val Ser  Val Thr Glu Ser Lys  Glu Ser Ile 
    1490                 1495                 1500             


Leu Gly  Gly Val Leu Lys Val  Leu Leu His Ser Met  Ala Cys Asn 
    1505                 1510                 1515             


Gln Ser  Ala Val Tyr Leu Gln  His Cys Phe Ala Thr  Gln Arg Ala 
    1520                 1525                 1530             


Leu Val  Ser Lys Phe Pro Glu  Leu Leu Phe Glu Glu  Glu Thr Glu 
    1535                 1540                 1545             


Gln Cys  Ala Asp Leu Cys Leu  Arg Leu Leu Arg His  Cys Ser Ser 
    1550                 1555                 1560             


Ser Ile  Gly Thr Ile Arg Ser  His Ala Ser Ala Ser  Leu Tyr Leu 
    1565                 1570                 1575             


Leu Met  Arg Gln Asn Phe Glu  Ile Gly Asn Asn Phe  Ala Arg Val 
    1580                 1585                 1590             


Lys Met  Gln Val Thr Met Ser  Leu Ser Ser Leu Val  Gly Thr Ser 
    1595                 1600                 1605             


Gln Asn  Phe Asn Glu Glu Phe  Leu Arg Arg Ser Leu  Lys Thr Ile 
    1610                 1615                 1620             


Leu Thr  Tyr Ala Glu Glu Asp  Leu Glu Leu Arg Glu  Thr Thr Phe 
    1625                 1630                 1635             


Pro Asp  Gln Val Gln Asp Leu  Val Phe Asn Leu His  Met Ile Leu 
    1640                 1645                 1650             


Ser Asp  Thr Val Lys Met Lys  Glu His Gln Glu Asp  Pro Glu Met 
    1655                 1660                 1665             


Leu Ile  Asp Leu Met Tyr Arg  Ile Ala Lys Gly Tyr  Gln Thr Ser 
    1670                 1675                 1680             


Pro Asp  Leu Arg Leu Thr Trp  Leu Gln Asn Met Ala  Gly Lys His 
    1685                 1690                 1695             


Ser Glu  Arg Ser Asn His Ala  Glu Ala Ala Gln Cys  Leu Val His 
    1700                 1705                 1710             


Ser Ala  Ala Leu Val Ala Glu  Tyr Leu Ser Met Leu  Glu Asp Arg 
    1715                 1720                 1725             


Lys Tyr  Leu Pro Val Gly Cys  Val Thr Phe Gln Asn  Ile Ser Ser 
    1730                 1735                 1740             


Asn Val  Leu Glu Glu Ser Ala  Val Ser Asp Asp Val  Val Ser Pro 
    1745                 1750                 1755             


Asp Glu  Glu Gly Ile Cys Ser  Gly Lys Tyr Phe Thr  Glu Ser Gly 
    1760                 1765                 1770             


Leu Val  Gly Leu Leu Glu Gln  Ala Ala Ala Ser Phe  Ser Met Ala 
    1775                 1780                 1785             


Gly Met  Tyr Glu Ala Val Asn  Glu Val Tyr Lys Val  Leu Ile Pro 
    1790                 1795                 1800             


Ile His  Glu Ala Asn Arg Asp  Ala Lys Lys Leu Ser  Thr Ile His 
    1805                 1810                 1815             


Gly Lys  Leu Gln Glu Ala Phe  Ser Lys Ile Val His  Gln Ser Thr 
    1820                 1825                 1830             


Gly Trp  Glu Arg Met Phe Gly  Thr Tyr Phe Arg Val  Gly Phe Tyr 
    1835                 1840                 1845             


Gly Thr  Lys Phe Gly Asp Leu  Asp Glu Gln Glu Phe  Val Tyr Lys 
    1850                 1855                 1860             


Glu Pro  Ala Ile Thr Lys Leu  Ala Glu Ile Ser His  Arg Leu Glu 
    1865                 1870                 1875             


Gly Phe  Tyr Gly Glu Arg Phe  Gly Glu Asp Val Val  Glu Val Ile 
    1880                 1885                 1890             


Lys Asp  Ser Asn Pro Val Asp  Lys Cys Lys Leu Asp  Pro Asn Lys 
    1895                 1900                 1905             


Ala Tyr  Ile Gln Ile Thr Tyr  Val Glu Pro Tyr Phe  Asp Thr Tyr 
    1910                 1915                 1920             


Glu Met  Lys Asp Arg Ile Thr  Tyr Phe Asp Lys Asn  Tyr Asn Leu 
    1925                 1930                 1935             


Arg Arg  Phe Met Tyr Cys Thr  Pro Phe Thr Leu Asp  Gly Arg Ala 
    1940                 1945                 1950             


His Gly  Glu Leu His Glu Gln  Phe Lys Arg Lys Thr  Ile Leu Thr 
    1955                 1960                 1965             


Thr Ser  His Ala Phe Pro Tyr  Ile Lys Thr Arg Val  Asn Val Thr 
    1970                 1975                 1980             


His Lys  Glu Glu Ile Ile Leu  Thr Pro Ile Glu Val  Ala Ile Glu 
    1985                 1990                 1995             


Asp Met  Gln Lys Lys Thr Gln  Glu Leu Ala Phe Ala  Thr His Gln 
    2000                 2005                 2010             


Asp Pro  Ala Asp Pro Lys Met  Leu Gln Met Val Leu  Gln Gly Ser 
    2015                 2020                 2025             


Val Gly  Thr Thr Val Asn Gln  Gly Pro Leu Glu Val  Ala Gln Val 
    2030                 2035                 2040             


Phe Leu  Ser Glu Ile Pro Ser  Asp Pro Lys Leu Phe  Arg His His 
    2045                 2050                 2055             


Asn Lys  Leu Arg Leu Cys Phe  Lys Asp Phe Thr Lys  Arg Cys Glu 
    2060                 2065                 2070             


Asp Ala  Leu Arg Lys Asn Lys  Ser Leu Ile Gly Pro  Asp Gln Lys 
    2075                 2080                 2085             


Glu Tyr  Gln Arg Glu Leu Glu  Arg Asn Tyr His Arg  Leu Lys Glu 
    2090                 2095                 2100             


Ala Leu  Gln Pro Leu Ile Asn  Arg Lys Ile Pro Gln  Leu Tyr Lys 
    2105                 2110                 2115             


Ala Val  Leu Pro Val Thr Cys  His Arg Asp Ser Phe  Ser Arg Met 
    2120                 2125                 2130             


Ser Leu  Arg Lys Met Asp Leu  
    2135                 2140 


<210>  3209
<211>  2099
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK8__Homo_sapiens__NP_982272

<400>  3209

Met Ala Thr Leu Pro Ser Ala Glu Arg Arg Ala Phe Ala Leu Lys Ile 
1               5                   10                  15      


Asn Arg Tyr Ser Ser Ala Glu Ile Arg Lys Gln Phe Thr Leu Pro Pro 
            20                  25                  30          


Asn Leu Gly Gln Tyr His Arg Gln Ser Ile Ser Thr Ser Gly Phe Pro 
        35                  40                  45              


Ser Leu Gln Leu Pro Gln Phe Tyr Asp Pro Val Glu Pro Val Asp Phe 
    50                  55                  60                  


Glu Gly Leu Leu Met Thr His Leu Asn Ser Leu Asp Val Gln Leu Ala 
65                  70                  75                  80  


Gln Glu Leu Gly Asp Phe Thr Asp Asp Asp Leu Asp Val Val Phe Thr 
                85                  90                  95      


Pro Lys Glu Cys Arg Thr Leu Gln Pro Ser Leu Pro Glu Glu Gly Val 
            100                 105                 110         


Glu Leu Asp Pro His Val Arg Asp Cys Val Gln Thr Tyr Ile Arg Glu 
        115                 120                 125             


Trp Leu Ile Val Asn Arg Lys Asn Gln Gly Ser Pro Glu Ile Cys Gly 
    130                 135                 140                 


Phe Lys Lys Thr Gly Ser Arg Lys Asp Phe His Lys Thr Leu Pro Lys 
145                 150                 155                 160 


Gln Thr Phe Glu Ser Glu Thr Leu Glu Cys Ser Glu Pro Ala Ala Gln 
                165                 170                 175     


Ala Gly Pro Arg His Leu Asn Val Leu Cys Asp Val Ser Gly Lys Gly 
            180                 185                 190         


Pro Val Thr Ala Cys Asp Phe Asp Leu Arg Ser Leu Gln Pro Asp Lys 
        195                 200                 205             


Arg Leu Glu Asn Leu Leu Gln Gln Val Ser Ala Glu Asp Phe Glu Lys 
    210                 215                 220                 


Gln Asn Glu Glu Ala Arg Arg Thr Asn Arg Gln Ala Glu Leu Phe Ala 
225                 230                 235                 240 


Leu Tyr Pro Ser Val Asp Glu Glu Asp Ala Val Glu Ile Arg Pro Val 
                245                 250                 255     


Pro Glu Cys Pro Lys Glu His Leu Gly Asn Arg Ile Leu Val Lys Leu 
            260                 265                 270         


Leu Thr Leu Lys Phe Glu Ile Glu Ile Glu Pro Leu Phe Ala Ser Ile 
        275                 280                 285             


Ala Leu Tyr Asp Val Lys Glu Arg Lys Lys Ile Ser Glu Asn Phe His 
    290                 295                 300                 


Cys Asp Leu Asn Ser Asp Gln Phe Lys Gly Phe Leu Arg Ala His Thr 
305                 310                 315                 320 


Pro Ser Val Ala Ala Ser Ser Gln Ala Arg Ser Ala Val Phe Ser Val 
                325                 330                 335     


Thr Tyr Pro Ser Ser Asp Ile Tyr Leu Val Val Lys Ile Glu Lys Val 
            340                 345                 350         


Leu Gln Gln Gly Glu Ile Gly Asp Cys Ala Glu Pro Tyr Thr Val Ile 
        355                 360                 365             


Lys Glu Ser Asp Gly Gly Lys Ser Lys Glu Lys Ile Glu Lys Leu Lys 
    370                 375                 380                 


Leu Gln Ala Glu Ser Phe Cys Gln Arg Leu Gly Lys Tyr Arg Met Pro 
385                 390                 395                 400 


Phe Ala Trp Ala Pro Ile Ser Leu Ser Ser Phe Phe Asn Val Ser Thr 
                405                 410                 415     


Leu Glu Arg Glu Val Thr Asp Val Asp Ser Val Val Gly Arg Ser Ser 
            420                 425                 430         


Val Gly Glu Arg Arg Thr Leu Ala Gln Ser Arg Arg Leu Ser Glu Arg 
        435                 440                 445             


Ala Leu Ser Leu Glu Glu Asn Gly Val Gly Ser Asn Phe Lys Thr Ser 
    450                 455                 460                 


Thr Leu Ser Val Ser Ser Phe Phe Lys Gln Glu Gly Asp Arg Leu Ser 
465                 470                 475                 480 


Asp Glu Asp Leu Phe Lys Phe Leu Ala Asp Tyr Lys Arg Ser Ser Ser 
                485                 490                 495     


Leu Gln Arg Arg Val Lys Ser Ile Pro Gly Leu Leu Arg Leu Glu Ile 
            500                 505                 510         


Ser Thr Ala Pro Glu Ile Ile Asn Cys Cys Leu Thr Pro Glu Met Leu 
        515                 520                 525             


Pro Val Lys Pro Phe Pro Glu Asn Arg Thr Arg Pro His Lys Glu Ile 
    530                 535                 540                 


Leu Glu Phe Pro Thr Arg Glu Val Tyr Val Pro His Thr Val Tyr Arg 
545                 550                 555                 560 


Asn Leu Leu Tyr Val Tyr Pro Gln Arg Leu Asn Phe Val Asn Lys Leu 
                565                 570                 575     


Ala Ser Ala Arg Asn Ile Thr Ile Lys Ile Gln Phe Met Cys Gly Glu 
            580                 585                 590         


Asp Ala Ser Asn Ala Met Pro Val Ile Phe Gly Lys Ser Ser Gly Pro 
        595                 600                 605             


Glu Phe Leu Gln Glu Val Tyr Thr Ala Val Thr Tyr His Asn Lys Ser 
    610                 615                 620                 


Pro Asp Phe Tyr Glu Glu Val Lys Ile Lys Leu Pro Ala Lys Leu Thr 
625                 630                 635                 640 


Val Asn His His Leu Leu Phe Thr Phe Tyr His Ile Ser Cys Gln Gln 
                645                 650                 655     


Lys Gln Gly Ala Ser Val Glu Thr Leu Leu Gly Tyr Ser Trp Leu Pro 
            660                 665                 670         


Ile Leu Leu Asn Glu Arg Leu Gln Thr Gly Ser Tyr Cys Leu Pro Val 
        675                 680                 685             


Ala Leu Glu Lys Leu Pro Pro Asn Tyr Ser Met His Ser Ala Glu Lys 
    690                 695                 700                 


Val Pro Leu Gln Asn Pro Pro Ile Lys Trp Ala Glu Gly His Lys Gly 
705                 710                 715                 720 


Val Phe Asn Ile Glu Val Gln Ala Val Ser Ser Val His Thr Gln Asp 
                725                 730                 735     


Asn His Leu Glu Lys Phe Phe Thr Leu Cys His Ser Leu Glu Ser Gln 
            740                 745                 750         


Val Thr Phe Pro Ile Arg Val Leu Asp Gln Lys Ile Ser Glu Met Ala 
        755                 760                 765             


Leu Glu His Glu Leu Lys Leu Ser Ile Ile Cys Leu Asn Ser Ser Arg 
    770                 775                 780                 


Leu Glu Pro Leu Val Leu Phe Leu His Leu Val Leu Asp Lys Leu Phe 
785                 790                 795                 800 


Gln Leu Ser Val Gln Pro Met Val Ile Ala Gly Gln Thr Ala Asn Phe 
                805                 810                 815     


Ser Gln Phe Ala Phe Glu Ser Val Val Ala Ile Ala Asn Ser Leu His 
            820                 825                 830         


Asn Ser Lys Asp Leu Ser Lys Asp Gln His Gly Arg Asn Cys Leu Leu 
        835                 840                 845             


Ala Ser Tyr Val His Tyr Val Phe Arg Leu Pro Glu Val Gln Arg Asp 
    850                 855                 860                 


Val Pro Lys Ser Gly Ala Pro Thr Ala Leu Leu Asp Pro Arg Ser Tyr 
865                 870                 875                 880 


His Thr Tyr Gly Arg Thr Ser Ala Ala Ala Val Ser Ser Lys Leu Leu 
                885                 890                 895     


Gln Ala Arg Val Met Ser Ser Ser Asn Pro Asp Leu Ala Gly Thr His 
            900                 905                 910         


Ser Ala Ala Asp Glu Glu Val Lys Asn Ile Met Ser Ser Lys Ile Ala 
        915                 920                 925             


Asp Arg Asn Cys Ser Arg Met Ser Tyr Tyr Cys Ser Gly Ser Ser Asp 
    930                 935                 940                 


Ala Pro Ser Ser Pro Ala Ala Pro Arg Pro Ala Ser Lys Lys His Phe 
945                 950                 955                 960 


His Glu Glu Leu Ala Leu Gln Met Val Val Ser Thr Gly Met Val Arg 
                965                 970                 975     


Glu Thr Val Phe Lys Tyr Ala Trp Phe Phe Phe Glu Leu Leu Val Lys 
            980                 985                 990         


Ser Met Ala Gln His Val His Asn  Met Asp Lys Arg Asp  Ser Phe Arg 
        995                 1000                 1005             


Arg Thr  Arg Phe Ser Asp Arg  Phe Met Asp Asp Ile  Thr Thr Ile 
    1010                 1015                 1020             


Val Asn  Val Val Thr Ser Glu  Ile Ala Ala Leu Leu  Val Lys Pro 
    1025                 1030                 1035             


Gln Lys  Glu Asn Glu Gln Ala  Glu Lys Met Asn Ile  Ser Leu Ala 
    1040                 1045                 1050             


Phe Phe  Leu Tyr Asp Leu Leu  Ser Leu Met Asp Arg  Gly Phe Val 
    1055                 1060                 1065             


Phe Asn  Leu Ile Arg His Tyr  Cys Ser Gln Leu Ser  Ala Lys Leu 
    1070                 1075                 1080             


Ser Asn  Leu Pro Thr Leu Ile  Ser Met Arg Leu Glu  Phe Leu Arg 
    1085                 1090                 1095             


Ile Leu  Cys Ser His Glu His  Tyr Leu Asn Leu Asn  Leu Phe Phe 
    1100                 1105                 1110             


Met Asn  Ala Asp Thr Ala Pro  Thr Ser Pro Cys Pro  Ser Ile Ser 
    1115                 1120                 1125             


Ser Gln  Asn Ser Ser Ser Cys  Ser Ser Phe Gln Asp  Gln Lys Ile 
    1130                 1135                 1140             


Ala Ser  Met Phe Asp Leu Thr  Ser Glu Tyr Arg Gln  Gln His Phe 
    1145                 1150                 1155             


Leu Thr  Gly Leu Leu Phe Thr  Glu Leu Ala Ala Ala  Leu Asp Ala 
    1160                 1165                 1170             


Glu Gly  Glu Gly Ile Ser Lys  Val Gln Arg Lys Ala  Val Ser Ala 
    1175                 1180                 1185             


Ile His  Ser Leu Leu Ser Ser  His Asp Leu Asp Pro  Arg Cys Val 
    1190                 1195                 1200             


Lys Pro  Glu Val Lys Val Lys  Ile Ala Ala Leu Tyr  Leu Pro Leu 
    1205                 1210                 1215             


Val Gly  Ile Ile Leu Asp Ala  Leu Pro Gln Leu Cys  Asp Phe Thr 
    1220                 1225                 1230             


Val Ala  Asp Thr Arg Arg Tyr  Arg Thr Ser Gly Ser  Asp Glu Glu 
    1235                 1240                 1245             


Gln Glu  Gly Ala Gly Ala Ile  Asn Gln Asn Val Ala  Leu Ala Ile 
    1250                 1255                 1260             


Ala Gly  Asn Asn Phe Asn Leu  Lys Thr Ser Gly Ile  Val Leu Ser 
    1265                 1270                 1275             


Ser Leu  Pro Tyr Lys Gln Tyr  Asn Met Leu Asn Ala  Asp Thr Thr 
    1280                 1285                 1290             


Arg Asn  Leu Met Ile Cys Phe  Leu Trp Ile Met Lys  Asn Ala Asp 
    1295                 1300                 1305             


Gln Ser  Leu Ile Arg Lys Trp  Ile Ala Asp Leu Pro  Ser Thr Gln 
    1310                 1315                 1320             


Leu Asn  Arg Ile Leu Asp Leu  Leu Phe Ile Cys Val  Leu Cys Phe 
    1325                 1330                 1335             


Glu Tyr  Lys Gly Lys Gln Ser  Ser Asp Lys Val Ser  Thr Gln Val 
    1340                 1345                 1350             


Leu Gln  Lys Ser Arg Asp Val  Lys Ala Arg Leu Glu  Glu Ala Leu 
    1355                 1360                 1365             


Leu Arg  Gly Glu Gly Ala Arg  Gly Glu Met Met Arg  Arg Arg Ala 
    1370                 1375                 1380             


Pro Gly  Asn Asp Arg Phe Pro  Gly Leu Asn Glu Asn  Leu Arg Trp 
    1385                 1390                 1395             


Lys Lys  Glu Gln Thr His Trp  Arg Gln Ala Asn Glu  Lys Leu Asp 
    1400                 1405                 1410             


Lys Thr  Lys Ala Glu Leu Asp  Gln Glu Ala Leu Ile  Ser Gly Asn 
    1415                 1420                 1425             


Leu Ala  Thr Glu Ala His Leu  Ile Ile Leu Asp Met  Gln Glu Asn 
    1430                 1435                 1440             


Ile Ile  Gln Ala Ser Ser Ala  Leu Asp Cys Lys Asp  Ser Leu Leu 
    1445                 1450                 1455             


Gly Gly  Val Leu Arg Val Leu  Val Asn Ser Leu Asn  Cys Asp Gln 
    1460                 1465                 1470             


Ser Thr  Thr Tyr Leu Thr His  Cys Phe Ala Thr Leu  Arg Ala Leu 
    1475                 1480                 1485             


Ile Ala  Lys Phe Gly Asp Leu  Leu Phe Glu Glu Glu  Val Glu Gln 
    1490                 1495                 1500             


Cys Phe  Asp Leu Cys His Gln  Val Leu His His Cys  Ser Ser Ser 
    1505                 1510                 1515             


Met Asp  Val Thr Arg Ser Gln  Ala Cys Ala Thr Leu  Tyr Leu Leu 
    1520                 1525                 1530             


Met Arg  Phe Ser Phe Gly Ala  Thr Ser Asn Phe Ala  Arg Val Lys 
    1535                 1540                 1545             


Met Gln  Val Thr Met Ser Leu  Ala Ser Leu Val Gly  Arg Ala Pro 
    1550                 1555                 1560             


Asp Phe  Asn Glu Glu His Leu  Arg Arg Ser Leu Arg  Thr Ile Leu 
    1565                 1570                 1575             


Ala Tyr  Ser Glu Glu Asp Thr  Ala Met Gln Met Thr  Pro Phe Pro 
    1580                 1585                 1590             


Thr Gln  Val Glu Glu Leu Leu  Cys Asn Leu Asn Ser  Ile Leu Tyr 
    1595                 1600                 1605             


Asp Thr  Val Lys Met Arg Glu  Phe Gln Glu Asp Pro  Glu Met Leu 
    1610                 1615                 1620             


Met Asp  Leu Met Tyr Arg Ile  Ala Lys Ser Tyr Gln  Ala Ser Pro 
    1625                 1630                 1635             


Asp Leu  Arg Leu Thr Trp Leu  Gln Asn Met Ala Glu  Lys His Thr 
    1640                 1645                 1650             


Lys Lys  Lys Cys Tyr Thr Glu  Ala Ala Met Cys Leu  Val His Ala 
    1655                 1660                 1665             


Ala Ala  Leu Val Ala Glu Tyr  Leu Ser Met Leu Glu  Asp His Ser 
    1670                 1675                 1680             


Tyr Leu  Pro Val Gly Ser Val  Ser Phe Gln Asn Ile  Ser Ser Asn 
    1685                 1690                 1695             


Val Leu  Glu Glu Ser Val Val  Ser Glu Asp Thr Leu  Ser Pro Asp 
    1700                 1705                 1710             


Glu Asp  Gly Val Cys Ala Gly  Gln Tyr Phe Thr Glu  Ser Gly Leu 
    1715                 1720                 1725             


Val Gly  Leu Leu Glu Gln Ala  Ala Glu Leu Phe Ser  Thr Gly Gly 
    1730                 1735                 1740             


Leu Tyr  Glu Thr Val Asn Glu  Val Tyr Lys Leu Val  Ile Pro Ile 
    1745                 1750                 1755             


Leu Glu  Ala His Arg Glu Phe  Arg Lys Leu Thr Leu  Thr His Ser 
    1760                 1765                 1770             


Lys Leu  Gln Arg Ala Phe Asp  Ser Ile Val Asn Lys  Asp His Lys 
    1775                 1780                 1785             


Arg Met  Phe Gly Thr Tyr Phe  Arg Val Gly Phe Phe  Gly Ser Lys 
    1790                 1795                 1800             


Phe Gly  Asp Leu Asp Glu Gln  Glu Phe Val Tyr Lys  Glu Pro Ala 
    1805                 1810                 1815             


Ile Thr  Lys Leu Pro Glu Ile  Ser His Arg Leu Glu  Ala Phe Tyr 
    1820                 1825                 1830             


Gly Gln  Cys Phe Gly Ala Glu  Phe Val Glu Val Ile  Lys Asp Ser 
    1835                 1840                 1845             


Thr Pro  Val Asp Lys Thr Lys  Leu Asp Pro Asn Lys  Ala Tyr Ile 
    1850                 1855                 1860             


Gln Ile  Thr Phe Val Glu Pro  Tyr Phe Asp Glu Tyr  Glu Met Lys 
    1865                 1870                 1875             


Asp Arg  Val Thr Tyr Phe Glu  Lys Asn Phe Asn Leu  Arg Arg Phe 
    1880                 1885                 1890             


Met Tyr  Thr Thr Pro Phe Thr  Leu Glu Gly Arg Pro  Arg Gly Glu 
    1895                 1900                 1905             


Leu His  Glu Gln Tyr Arg Arg  Asn Thr Val Leu Thr  Thr Met His 
    1910                 1915                 1920             


Ala Phe  Pro Tyr Ile Lys Thr  Arg Ile Ser Val Ile  Gln Lys Glu 
    1925                 1930                 1935             


Glu Phe  Val Leu Thr Pro Ile  Glu Val Ala Ile Glu  Asp Met Lys 
    1940                 1945                 1950             


Lys Lys  Thr Leu Gln Leu Ala  Val Ala Ile Asn Gln  Glu Pro Pro 
    1955                 1960                 1965             


Asp Ala  Lys Met Leu Gln Met  Val Leu Gln Gly Ser  Val Gly Ala 
    1970                 1975                 1980             


Thr Val  Asn Gln Gly Pro Leu  Glu Val Ala Gln Val  Phe Leu Ala 
    1985                 1990                 1995             


Glu Ile  Pro Ala Asp Pro Lys  Leu Tyr Arg His His  Asn Lys Leu 
    2000                 2005                 2010             


Arg Leu  Cys Phe Lys Glu Phe  Ile Met Arg Cys Gly  Glu Ala Val 
    2015                 2020                 2025             


Glu Lys  Asn Lys Arg Leu Ile  Thr Ala Asp Gln Arg  Glu Tyr Gln 
    2030                 2035                 2040             


Gln Glu  Leu Lys Lys Asn Tyr  Asn Lys Leu Lys Glu  Asn Leu Arg 
    2045                 2050                 2055             


Pro Met  Ile Glu Arg Lys Ile  Pro Glu Leu Tyr Lys  Pro Ile Phe 
    2060                 2065                 2070             


Arg Val  Glu Ser Gln Lys Arg  Asp Ser Phe His Arg  Ser Ser Phe 
    2075                 2080                 2085             


Arg Lys  Cys Glu Thr Gln Leu  Ser Gln Gly Ser 
    2090                 2095                 


<210>  3210
<211>  2068
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOCK9__Homo_sapiens__NP_001123520

<400>  3210

Met Gln Ala Asp Lys Cys Arg Thr Ser Ser Arg Ser Val Lys Lys Glu 
1               5                   10                  15      


Leu Val Ile Glu Ser Pro Leu Gln Tyr Lys Asp Ala Ala Gln Gly Glu 
            20                  25                  30          


Val Glu Ala Glu Ser Pro Gly Pro Val Pro Ala Lys Pro Lys Leu Ile 
        35                  40                  45              


Glu Pro Leu Asp Tyr Glu Asn Val Ile Val Gln Lys Lys Thr Gln Ile 
    50                  55                  60                  


Leu Asn Asp Cys Leu Arg Glu Met Leu Leu Phe Pro Tyr Asp Asp Phe 
65                  70                  75                  80  


Gln Thr Ala Ile Leu Arg Arg Gln Gly Arg Tyr Ile Cys Ser Thr Val 
                85                  90                  95      


Pro Ala Lys Ala Glu Glu Glu Ala Gln Ser Leu Phe Val Thr Glu Cys 
            100                 105                 110         


Ile Lys Thr Tyr Asn Ser Asp Trp His Leu Val Asn Tyr Lys Tyr Glu 
        115                 120                 125             


Asp Tyr Ser Gly Glu Phe Arg Gln Leu Pro Asn Lys Val Val Lys Leu 
    130                 135                 140                 


Asp Lys Leu Pro Val His Val Tyr Glu Val Asp Glu Glu Val Asp Lys 
145                 150                 155                 160 


Asp Glu Asp Ala Ala Ser Leu Gly Ser Gln Lys Gly Gly Ile Thr Lys 
                165                 170                 175     


His Gly Trp Leu Tyr Lys Gly Asn Met Asn Ser Ala Ile Ser Val Thr 
            180                 185                 190         


Met Arg Ser Phe Lys Arg Arg Phe Phe His Leu Ile Gln Leu Gly Asp 
        195                 200                 205             


Gly Ser Tyr Asn Leu Asn Phe Tyr Lys Asp Glu Lys Ile Ser Lys Glu 
    210                 215                 220                 


Pro Lys Gly Ser Ile Phe Leu Asp Ser Cys Met Gly Val Val Gln Asn 
225                 230                 235                 240 


Asn Lys Val Arg Arg Phe Ala Phe Glu Leu Lys Met Gln Asp Lys Ser 
                245                 250                 255     


Ser Tyr Leu Leu Ala Ala Asp Ser Glu Val Glu Met Glu Glu Trp Ile 
            260                 265                 270         


Thr Ile Leu Asn Lys Ile Leu Gln Leu Asn Phe Glu Ala Ala Met Gln 
        275                 280                 285             


Glu Lys Arg Asn Gly Asp Ser His Glu Asp Asp Glu Gln Ser Lys Leu 
    290                 295                 300                 


Glu Gly Ser Gly Ser Gly Leu Asp Ser Tyr Leu Pro Glu Leu Ala Lys 
305                 310                 315                 320 


Ser Ala Arg Glu Ala Glu Ile Lys Leu Lys Ser Glu Ser Arg Val Lys 
                325                 330                 335     


Leu Phe Tyr Leu Asp Pro Asp Ala Gln Lys Leu Asp Phe Ser Ser Ala 
            340                 345                 350         


Glu Pro Glu Val Lys Ser Phe Glu Glu Lys Phe Gly Lys Arg Ile Leu 
        355                 360                 365             


Val Lys Cys Asn Asp Leu Ser Phe Asn Leu Gln Cys Cys Val Ala Glu 
    370                 375                 380                 


Asn Glu Glu Gly Pro Thr Thr Asn Val Glu Pro Phe Phe Val Thr Leu 
385                 390                 395                 400 


Ser Leu Phe Asp Ile Lys Tyr Asn Arg Lys Ile Ser Ala Asp Phe His 
                405                 410                 415     


Val Asp Leu Asn His Phe Ser Val Arg Gln Met Leu Ala Thr Thr Ser 
            420                 425                 430         


Pro Ala Leu Met Asn Gly Ser Gly Gln Ser Pro Ser Val Leu Lys Gly 
        435                 440                 445             


Ile Leu His Glu Ala Ala Met Gln Tyr Pro Lys Gln Gly Ile Phe Ser 
    450                 455                 460                 


Val Thr Cys Pro His Pro Asp Ile Phe Leu Val Ala Arg Ile Glu Lys 
465                 470                 475                 480 


Val Leu Gln Gly Ser Ile Thr His Cys Ala Glu Pro Tyr Met Lys Ser 
                485                 490                 495     


Ser Asp Ser Ser Lys Val Ala Gln Lys Val Leu Lys Asn Ala Lys Gln 
            500                 505                 510         


Ala Cys Gln Arg Leu Gly Gln Tyr Arg Met Pro Phe Ala Trp Ala Ala 
        515                 520                 525             


Arg Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala Arg 
    530                 535                 540                 


Phe Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp Asp 
545                 550                 555                 560 


Met Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala Lys 
                565                 570                 575     


Leu Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val Ser 
            580                 585                 590         


Ser Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys Gln 
        595                 600                 605             


Phe Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu Phe 
    610                 615                 620                 


Val Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr Asn 
625                 630                 635                 640 


His Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys Ser 
                645                 650                 655     


Phe Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp Ser 
            660                 665                 670         


Asp Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro Gly 
        675                 680                 685             


Gly Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His His 
    690                 695                 700                 


Gln Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr Gln 
705                 710                 715                 720 


Leu His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser Cys 
                725                 730                 735     


Asp Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu Thr 
            740                 745                 750         


Gln Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val Val 
        755                 760                 765             


Thr Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly Tyr 
    770                 775                 780                 


Leu Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu Ile 
785                 790                 795                 800 


Lys Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His Leu 
                805                 810                 815     


Val Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe Gln 
            820                 825                 830         


Tyr Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu Leu 
        835                 840                 845             


Val Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met Ile 
    850                 855                 860                 


Ala Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr Arg 
865                 870                 875                 880 


Ala Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile His 
                885                 890                 895     


Val Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg Ser 
            900                 905                 910         


Tyr Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu Tyr 
        915                 920                 925             


Lys Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu Lys 
    930                 935                 940                 


Pro Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser Trp 
945                 950                 955                 960 


Phe Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile Glu 
                965                 970                 975     


Asn Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser Tyr 
            980                 985                 990         


His His Ala Val Glu Thr Val Val  Asn Met Leu Met Pro  His Ile Thr 
        995                 1000                 1005             


Gln Lys  Phe Arg Asp Asn Pro  Glu Ala Ser Lys Asn  Ala Asn His 
    1010                 1015                 1020             


Ser Leu  Ala Val Phe Ile Lys  Arg Cys Phe Thr Phe  Met Asp Arg 
    1025                 1030                 1035             


Gly Phe  Val Phe Lys Gln Ile  Asn Asn Tyr Ile Ser  Cys Phe Ala 
    1040                 1045                 1050             


Pro Gly  Asp Pro Lys Thr Leu  Phe Glu Tyr Lys Phe  Glu Phe Leu 
    1055                 1060                 1065             


Arg Val  Val Cys Asn His Glu  His Tyr Ile Pro Leu  Asn Leu Pro 
    1070                 1075                 1080             


Met Pro  Phe Gly Lys Gly Arg  Ile Gln Arg Tyr Gln  Asp Leu Gln 
    1085                 1090                 1095             


Leu Asp  Tyr Ser Leu Thr Asp  Glu Phe Cys Arg Asn  His Phe Leu 
    1100                 1105                 1110             


Val Gly  Leu Leu Leu Arg Glu  Val Gly Thr Ala Leu  Gln Glu Phe 
    1115                 1120                 1125             


Arg Glu  Val Arg Leu Ile Ala  Ile Ser Val Leu Lys  Asn Leu Leu 
    1130                 1135                 1140             


Ile Lys  His Ser Phe Asp Asp  Arg Tyr Ala Ser Arg  Ser His Gln 
    1145                 1150                 1155             


Ala Arg  Ile Ala Thr Leu Tyr  Leu Pro Leu Phe Gly  Leu Leu Ile 
    1160                 1165                 1170             


Glu Asn  Val Gln Arg Ile Asn  Val Arg Asp Val Ser  Pro Phe Pro 
    1175                 1180                 1185             


Val Asn  Ala Gly Met Thr Val  Lys Asp Glu Ser Leu  Ala Leu Pro 
    1190                 1195                 1200             


Ala Val  Asn Pro Leu Val Thr  Pro Gln Lys Gly Ser  Thr Leu Asp 
    1205                 1210                 1215             


Asn Ser  Leu His Lys Asp Leu  Leu Gly Ala Ile Ser  Gly Ile Ala 
    1220                 1225                 1230             


Ser Pro  Tyr Thr Thr Ser Thr  Pro Asn Ile Asn Ser  Val Arg Asn 
    1235                 1240                 1245             


Ala Asp  Ser Arg Gly Ser Leu  Ile Ser Thr Asp Ser  Gly Asn Ser 
    1250                 1255                 1260             


Leu Pro  Glu Arg Asn Ser Glu  Lys Ser Asn Ser Leu  Asp Lys His 
    1265                 1270                 1275             


Gln Gln  Ser Ser Thr Leu Gly  Asn Ser Val Val Arg  Cys Asp Lys 
    1280                 1285                 1290             


Leu Asp  Gln Ser Glu Ile Lys  Ser Leu Leu Met Cys  Phe Leu Tyr 
    1295                 1300                 1305             


Ile Leu  Lys Ser Met Ser Asp  Asp Ala Leu Phe Thr  Tyr Trp Asn 
    1310                 1315                 1320             


Lys Ala  Ser Thr Ser Glu Leu  Met Asp Phe Phe Thr  Ile Ser Glu 
    1325                 1330                 1335             


Val Cys  Leu His Gln Phe Gln  Tyr Met Gly Lys Arg  Tyr Ile Ala 
    1340                 1345                 1350             


Arg Thr  Gly Met Met His Ala  Arg Leu Gln Gln Leu  Gly Ser Leu 
    1355                 1360                 1365             


Asp Asn  Ser Leu Thr Phe Asn  His Ser Tyr Gly His  Ser Asp Ala 
    1370                 1375                 1380             


Asp Val  Leu His Gln Ser Leu  Leu Glu Ala Asn Ile  Ala Thr Glu 
    1385                 1390                 1395             


Val Cys  Leu Thr Ala Leu Asp  Thr Leu Ser Leu Phe  Thr Leu Ala 
    1400                 1405                 1410             


Phe Lys  Asn Gln Leu Leu Ala  Asp His Gly His Asn  Pro Leu Met 
    1415                 1420                 1425             


Lys Lys  Val Phe Asp Val Tyr  Leu Cys Phe Leu Gln  Lys His Gln 
    1430                 1435                 1440             


Ser Glu  Thr Ala Leu Lys Asn  Val Phe Thr Ala Leu  Arg Ser Leu 
    1445                 1450                 1455             


Ile Tyr  Lys Phe Pro Ser Thr  Phe Tyr Glu Gly Arg  Ala Asp Met 
    1460                 1465                 1470             


Cys Ala  Ala Leu Cys Tyr Glu  Ile Leu Lys Cys Cys  Asn Ser Lys 
    1475                 1480                 1485             


Leu Ser  Ser Ile Arg Thr Glu  Ala Ser Gln Leu Leu  Tyr Phe Leu 
    1490                 1495                 1500             


Met Arg  Asn Asn Phe Asp Tyr  Thr Gly Lys Lys Ser  Phe Val Arg 
    1505                 1510                 1515             


Thr His  Leu Gln Val Ile Ile  Ser Val Ser Gln Leu  Ile Ala Asp 
    1520                 1525                 1530             


Val Val  Gly Ile Gly Gly Thr  Arg Phe Gln Gln Ser  Leu Ser Ile 
    1535                 1540                 1545             


Ile Asn  Asn Cys Ala Asn Ser  Asp Arg Leu Ile Lys  His Thr Ser 
    1550                 1555                 1560             


Phe Ser  Ser Asp Val Lys Asp  Leu Thr Lys Arg Ile  Arg Thr Val 
    1565                 1570                 1575             


Leu Met  Ala Thr Ala Gln Met  Lys Glu His Glu Asn  Asp Pro Glu 
    1580                 1585                 1590             


Met Leu  Val Asp Leu Gln Tyr  Ser Leu Ala Lys Ser  Tyr Ala Ser 
    1595                 1600                 1605             


Thr Pro  Glu Leu Arg Lys Thr  Trp Leu Asp Ser Met  Ala Arg Ile 
    1610                 1615                 1620             


His Val  Lys Asn Gly Asp Leu  Ser Glu Ala Ala Met  Cys Tyr Val 
    1625                 1630                 1635             


His Val  Thr Ala Leu Val Ala  Glu Tyr Leu Thr Arg  Lys Glu Ala 
    1640                 1645                 1650             


Val Gln  Trp Glu Pro Pro Leu  Leu Pro His Ser His  Ser Ala Cys 
    1655                 1660                 1665             


Leu Arg  Arg Ser Arg Gly Gly  Val Phe Arg Gln Gly  Cys Thr Ala 
    1670                 1675                 1680             


Phe Arg  Val Ile Thr Pro Asn  Ile Asp Glu Glu Ala  Ser Met Met 
    1685                 1690                 1695             


Glu Asp  Val Gly Met Gln Asp  Val His Phe Asn Glu  Asp Val Leu 
    1700                 1705                 1710             


Met Glu  Leu Leu Glu Gln Cys  Ala Asp Gly Leu Trp  Lys Ala Glu 
    1715                 1720                 1725             


Arg Tyr  Glu Leu Ile Ala Asp  Ile Tyr Lys Leu Ile  Ile Pro Ile 
    1730                 1735                 1740             


Tyr Glu  Lys Arg Arg Asp Phe  Glu Arg Leu Ala His  Leu Tyr Asp 
    1745                 1750                 1755             


Thr Leu  His Arg Ala Tyr Ser  Lys Val Thr Glu Val  Met His Ser 
    1760                 1765                 1770             


Gly Arg  Arg Leu Leu Gly Thr  Tyr Phe Arg Val Ala  Phe Phe Gly 
    1775                 1780                 1785             


Gln Ala  Ala Gln Tyr Gln Phe  Thr Asp Ser Glu Thr  Asp Val Glu 
    1790                 1795                 1800             


Gly Phe  Phe Glu Asp Glu Asp  Gly Lys Glu Tyr Ile  Tyr Lys Glu 
    1805                 1810                 1815             


Pro Lys  Leu Thr Pro Leu Ser  Glu Ile Ser Gln Arg  Leu Leu Lys 
    1820                 1825                 1830             


Leu Tyr  Ser Asp Lys Phe Gly  Ser Glu Asn Val Lys  Met Ile Gln 
    1835                 1840                 1845             


Asp Ser  Gly Lys Val Asn Pro  Lys Asp Leu Asp Ser  Lys Tyr Ala 
    1850                 1855                 1860             


Tyr Ile  Gln Val Thr His Val  Ile Pro Phe Phe Asp  Glu Lys Glu 
    1865                 1870                 1875             


Leu Gln  Glu Arg Lys Thr Glu  Phe Glu Arg Ser His  Asn Ile Arg 
    1880                 1885                 1890             


Arg Phe  Met Phe Glu Met Pro  Phe Thr Gln Thr Gly  Lys Arg Gln 
    1895                 1900                 1905             


Gly Gly  Val Glu Glu Gln Cys  Lys Arg Arg Thr Ile  Leu Thr Ala 
    1910                 1915                 1920             


Ile His  Cys Phe Pro Tyr Val  Lys Lys Arg Ile Pro  Val Met Tyr 
    1925                 1930                 1935             


Gln His  His Thr Asp Leu Asn  Pro Ile Glu Val Ala  Ile Asp Glu 
    1940                 1945                 1950             


Met Ser  Lys Lys Val Ala Glu  Leu Arg Gln Leu Cys  Ser Ser Ala 
    1955                 1960                 1965             


Glu Val  Asp Met Ile Lys Leu  Gln Leu Lys Leu Gln  Gly Ser Val 
    1970                 1975                 1980             


Ser Val  Gln Val Asn Ala Gly  Pro Leu Ala Tyr Ala  Arg Ala Phe 
    1985                 1990                 1995             


Leu Asp  Asp Thr Asn Thr Lys  Arg Tyr Pro Asp Asn  Lys Val Lys 
    2000                 2005                 2010             


Leu Leu  Lys Glu Val Phe Arg  Gln Phe Val Glu Ala  Cys Gly Gln 
    2015                 2020                 2025             


Ala Leu  Ala Val Asn Glu Arg  Leu Ile Lys Glu Asp  Gln Leu Glu 
    2030                 2035                 2040             


Tyr Gln  Glu Glu Met Lys Ala  Asn Tyr Arg Glu Met  Ala Lys Glu 
    2045                 2050                 2055             


Leu Ser  Glu Ile Met His Glu  Gln Leu Gly 
    2060                 2065             


<210>  3211
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOHH__Homo_sapiens__XP_011526642

<400>  3211

Met Val Thr Glu Gln Glu Val Asp Ala Ile Gly Gln Thr Leu Val Asp 
1               5                   10                  15      


Pro Lys Gln Pro Leu Gln Ala Arg Phe Arg Ala Leu Phe Thr Leu Arg 
            20                  25                  30          


Gly Leu Gly Gly Pro Gly Ala Ile Ala Trp Ile Ser Gln Ala Phe Asp 
        35                  40                  45              


Asp Asp Ser Ala Leu Leu Lys His Glu Leu Ala Tyr Cys Leu Gly Gln 
    50                  55                  60                  


Met Gln Asp Ala Arg Ala Ile Pro Met Leu Val Asp Val Leu Gln Asp 
65                  70                  75                  80  


Thr Arg Gln Glu Pro Met Val Arg His Glu Ala Gly Glu Ala Leu Gly 
                85                  90                  95      


Ala Ile Gly Asp Pro Glu Val Leu Glu Ile Leu Lys Gln Tyr Ser Ser 
            100                 105                 110         


Asp Pro Val Ile Glu Val Ala Glu Thr Cys Gln Leu Ala Val Arg Arg 
        115                 120                 125             


Leu Glu Trp Leu Gln Gln His Gly Gly Glu Pro Ala Ala Gly Pro Tyr 
    130                 135                 140                 


Leu Ser Val Asp Pro Ala Pro Pro Ala Glu Glu Arg Asp Val Gly Arg 
145                 150                 155                 160 


Leu Arg Glu Ala Leu Leu Asp Glu Ser Arg Pro Leu Phe Glu Arg Tyr 
                165                 170                 175     


Arg Ala Met Phe Ala Leu Arg Asn Ala Gly Gly Glu Glu Ala Ala Leu 
            180                 185                 190         


Ala Leu Ala Glu Gly Leu His Cys Gly Ser Ala Leu Phe Arg His Glu 
        195                 200                 205             


Val Gly Tyr Val Leu Gly Gln Leu Gln His Glu Ala Ala Val Pro Gln 
    210                 215                 220                 


Leu Ala Ala Ala Leu Ala Arg Cys Thr Glu Asn Pro Met Val Arg His 
225                 230                 235                 240 


Glu Cys Ala Glu Ala Leu Gly Ala Ile Ala Arg Pro Ala Cys Leu Ala 
                245                 250                 255     


Ala Leu Gln Ala His Ala Asp Asp Pro Glu Arg Val Val Arg Glu Ser 
            260                 265                 270         


Cys Glu Val Ala Leu Asp Met Tyr Glu His Glu Thr Gly Arg Ala Phe 
        275                 280                 285             


Gln Tyr Ala Asp Gly Leu Glu Gln Leu Arg Gly Ala Pro Ser 
    290                 295                 300         


<210>  3212
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOK1__Homo_sapiens__NP_001184189

<400>  3212

Met Leu Glu Asn Ser Leu Tyr Ser Pro Thr Trp Glu Gly Ser Gln Phe 
1               5                   10                  15      


Trp Val Thr Val Gln Arg Thr Glu Ala Ala Glu Arg Cys Gly Leu His 
            20                  25                  30          


Gly Ser Tyr Val Leu Arg Val Glu Ala Glu Arg Leu Thr Leu Leu Thr 
        35                  40                  45              


Val Gly Ala Gln Ser Gln Ile Leu Glu Pro Leu Leu Ser Trp Pro Tyr 
    50                  55                  60                  


Thr Leu Leu Arg Arg Tyr Gly Arg Asp Lys Val Met Phe Ser Phe Glu 
65                  70                  75                  80  


Ala Gly Arg Arg Cys Pro Ser Gly Pro Gly Thr Phe Thr Phe Gln Thr 
                85                  90                  95      


Ala Gln Gly Asn Asp Ile Phe Gln Ala Val Glu Thr Ala Ile His Arg 
            100                 105                 110         


Gln Lys Ala Gln Gly Lys Ala Gly Gln Gly His Asp Val Leu Arg Ala 
        115                 120                 125             


Asp Ser His Glu Gly Glu Val Ala Glu Gly Lys Leu Pro Ser Pro Pro 
    130                 135                 140                 


Gly Pro Gln Glu Leu Leu Asp Ser Pro Pro Ala Leu Tyr Ala Glu Pro 
145                 150                 155                 160 


Leu Asp Ser Leu Arg Ile Ala Pro Cys Pro Ser Gln Asp Ser Leu Tyr 
                165                 170                 175     


Ser Asp Pro Leu Asp Ser Thr Ser Ala Gln Ala Gly Glu Gly Val Gln 
            180                 185                 190         


Arg Lys Lys Pro Leu Tyr Trp Asp Leu Tyr Glu His Ala Gln Gln Gln 
        195                 200                 205             


Leu Leu Lys Ala Lys Leu Thr Asp Pro Lys Glu Asp Pro Ile Tyr Asp 
    210                 215                 220                 


Glu Pro Glu Gly Leu Ala Pro Val Pro Pro Gln Gly Leu Tyr Asp Leu 
225                 230                 235                 240 


Pro Arg Glu Pro Lys Asp Ala Trp Trp Cys Gln Ala Arg Val Lys Glu 
                245                 250                 255     


Glu Gly Tyr Glu Leu Pro Tyr Asn Pro Ala Thr Asp Asp Tyr Ala Val 
            260                 265                 270         


Pro Pro Pro Arg Ser Thr Lys Pro Leu Leu Ala Pro Lys Pro Gln Gly 
        275                 280                 285             


Pro Ala Phe Pro Glu Pro Gly Thr Ala Thr Gly Ser Gly Ile Lys Ser 
    290                 295                 300                 


His Asn Ser Ala Leu Tyr Ser Gln Val Gln Lys Ser Gly Ala Ser Gly 
305                 310                 315                 320 


Ser Trp Asp Cys Gly Leu Ser Arg Val Gly Thr Asp Lys Thr Gly Val 
                325                 330                 335     


Lys Ser Glu Gly Ser Thr 
            340         


<210>  3213
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOK2__Homo_sapiens__NP_003965

<400>  3213

Met Gly Asp Gly Ala Val Lys Gln Gly Phe Leu Tyr Leu Gln Gln Gln 
1               5                   10                  15      


Gln Thr Phe Gly Lys Lys Trp Arg Arg Phe Gly Ala Ser Leu Tyr Gly 
            20                  25                  30          


Gly Ser Asp Cys Ala Leu Ala Arg Leu Glu Leu Gln Glu Gly Pro Glu 
        35                  40                  45              


Lys Pro Arg Arg Cys Glu Ala Ala Arg Lys Val Ile Arg Leu Ser Asp 
    50                  55                  60                  


Cys Leu Arg Val Ala Glu Ala Gly Gly Glu Ala Ser Ser Pro Arg Asp 
65                  70                  75                  80  


Thr Ser Ala Phe Phe Leu Glu Thr Lys Glu Arg Leu Tyr Leu Leu Ala 
                85                  90                  95      


Ala Pro Ala Ala Glu Arg Gly Asp Trp Val Gln Ala Ile Cys Leu Leu 
            100                 105                 110         


Ala Phe Pro Gly Gln Arg Lys Glu Leu Ser Gly Pro Glu Gly Lys Gln 
        115                 120                 125             


Ser Arg Pro Cys Met Glu Glu Asn Glu Leu Tyr Ser Ser Ala Val Thr 
    130                 135                 140                 


Val Gly Pro His Lys Glu Phe Ala Val Thr Met Arg Pro Thr Glu Ala 
145                 150                 155                 160 


Ser Glu Arg Cys His Leu Arg Gly Ser Tyr Thr Leu Arg Ala Gly Glu 
                165                 170                 175     


Ser Ala Leu Glu Leu Trp Gly Gly Pro Glu Pro Gly Thr Gln Leu Tyr 
            180                 185                 190         


Asp Trp Pro Tyr Arg Phe Leu Arg Arg Phe Gly Arg Asp Lys Val Thr 
        195                 200                 205             


Phe Ser Phe Glu Ala Gly Arg Arg Cys Val Ser Gly Glu Gly Asn Phe 
    210                 215                 220                 


Glu Phe Glu Thr Arg Gln Gly Asn Glu Ile Phe Leu Ala Leu Glu Glu 
225                 230                 235                 240 


Ala Ile Ser Ala Gln Lys Asn Ala Ala Pro Ala Thr Pro Gln Pro Gln 
                245                 250                 255     


Pro Ala Thr Ile Pro Ala Ser Leu Pro Arg Pro Asp Ser Pro Tyr Ser 
            260                 265                 270         


Arg Pro His Asp Ser Leu Pro Pro Pro Ser Pro Thr Thr Pro Val Pro 
        275                 280                 285             


Ala Pro Arg Pro Arg Gly Gln Glu Gly Glu Tyr Ala Val Pro Phe Asp 
    290                 295                 300                 


Ala Val Ala Arg Ser Leu Gly Lys Asn Phe Arg Gly Ile Leu Ala Val 
305                 310                 315                 320 


Pro Pro Gln Leu Leu Ala Asp Pro Leu Tyr Asp Ser Ile Glu Glu Thr 
                325                 330                 335     


Leu Pro Pro Arg Pro Asp His Ile Tyr Asp Glu Pro Glu Gly Val Ala 
            340                 345                 350         


Ala Leu Ser Leu Tyr Asp Ser Pro Gln Glu Pro Arg Gly Glu Ala Trp 
        355                 360                 365             


Arg Arg Gln Ala Thr Ala Asp Arg Asp Pro Ala Gly Leu Gln His Val 
    370                 375                 380                 


Gln Pro Ala Gly Gln Asp Phe Ser Ala Ser Gly Trp Gln Pro Gly Thr 
385                 390                 395                 400 


Glu Tyr Asp Asn Val Val Leu Lys Lys Gly Pro Lys 
                405                 410         


<210>  3214
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOK3__Homo_sapiens__NP_001138347

<400>  3214

Met Asp Pro Leu Glu Thr Pro Ile Lys Asp Gly Ile Leu Tyr Gln Gln 
1               5                   10                  15      


His Val Lys Phe Gly Lys Lys Cys Trp Arg Lys Val Trp Ala Leu Leu 
            20                  25                  30          


Tyr Ala Gly Gly Pro Ser Gly Val Ala Arg Leu Glu Ser Trp Glu Val 
        35                  40                  45              


Arg Asp Gly Gly Leu Gly Ala Ala Gly Asp Arg Ser Ala Gly Pro Gly 
    50                  55                  60                  


Arg Arg Gly Glu Arg Arg Val Ile Arg Leu Ala Asp Cys Val Ser Val 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Glu Ser Cys Pro Arg Asp Thr Gly Ala Phe Leu 
                85                  90                  95      


Leu Thr Thr Thr Glu Arg Ser His Leu Leu Ala Ala Gln His Arg Gln 
            100                 105                 110         


Ala Trp Met Gly Pro Ile Cys Gln Leu Ala Phe Pro Gly Thr Gly Glu 
        115                 120                 125             


Ala Ser Ser Gly Ser Thr Asp Ala Gln Ser Pro Lys Arg Gly Leu Val 
    130                 135                 140                 


Pro Met Glu Glu Asn Ser Ile Tyr Ser Ser Trp Gln Glu Val Gly Glu 
145                 150                 155                 160 


Phe Pro Val Val Val Gln Arg Thr Glu Ala Ala Thr Arg Cys Gln Leu 
                165                 170                 175     


Lys Gly Pro Ala Leu Leu Val Leu Gly Pro Asp Ala Ile Gln Leu Arg 
            180                 185                 190         


Glu Ala Lys Gly Thr Gln Ala Leu Tyr Ser Trp Pro Tyr His Phe Leu 
        195                 200                 205             


Arg Lys Phe Gly Ser Asp Lys Ile Leu Leu Gly Thr Pro Gly Val Ser 
    210                 215                 220                 


Leu Leu Ile Cys Lys Gly Glu Arg Thr Asp Asp Val Ser Gly Ile Ile 
225                 230                 235                 240 


Leu Asp Glu Ser Leu Leu Arg Ala Tyr Ser Val Pro Gly Ala Gly Gly 
                245                 250                 255     


His Ser Arg Val Gln Asp Ser Leu Gly Pro Val Leu Arg Glu Pro Thr 
            260                 265                 270         


Phe Gln Gly Glu Arg Ser Phe Leu Lys Thr Ser Met Leu Arg Ser Leu 
        275                 280                 285             


Leu Cys Ser Cys Ser Trp Arg His Pro Arg Ser Gln Pro Arg Thr Gln 
    290                 295                 300                 


Ala Ser Cys Leu Gln Gly Ser Asp Cys Pro Ala Pro His Arg Asn Ser 
305                 310                 315                 320 


Thr Ser Ala Ala His Thr Leu Gly Thr Ser 
                325                 330 


<210>  3215
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOK4__Homo_sapiens__NP_060580

<400>  3215

Met Ala Thr Asn Phe Ser Asp Ile Val Lys Gln Gly Tyr Val Lys Met 
1               5                   10                  15      


Lys Ser Arg Lys Leu Gly Ile Tyr Arg Arg Cys Trp Leu Val Phe Arg 
            20                  25                  30          


Lys Ser Ser Ser Lys Gly Pro Gln Arg Leu Glu Lys Tyr Pro Asp Glu 
        35                  40                  45              


Lys Ser Val Cys Leu Arg Gly Cys Pro Lys Val Thr Glu Ile Ser Asn 
    50                  55                  60                  


Val Lys Cys Val Thr Arg Leu Pro Lys Glu Thr Lys Arg Gln Ala Val 
65                  70                  75                  80  


Ala Ile Ile Phe Thr Asp Asp Ser Ala Arg Thr Phe Thr Cys Asp Ser 
                85                  90                  95      


Glu Leu Glu Ala Glu Glu Trp Tyr Lys Thr Leu Ser Val Glu Cys Leu 
            100                 105                 110         


Gly Ser Arg Leu Asn Asp Ile Ser Leu Gly Glu Pro Asp Leu Leu Ala 
        115                 120                 125             


Pro Gly Val Gln Cys Glu Gln Thr Asp Arg Phe Asn Val Phe Leu Leu 
    130                 135                 140                 


Pro Cys Pro Asn Leu Asp Val Tyr Gly Glu Cys Lys Leu Gln Ile Thr 
145                 150                 155                 160 


His Glu Asn Ile Tyr Leu Trp Asp Ile His Asn Pro Arg Val Lys Leu 
                165                 170                 175     


Val Ser Trp Pro Leu Cys Ser Leu Arg Arg Tyr Gly Arg Asp Ala Thr 
            180                 185                 190         


Arg Phe Thr Phe Glu Ala Gly Arg Met Cys Asp Ala Gly Glu Gly Leu 
        195                 200                 205             


Tyr Thr Phe Gln Thr Gln Glu Gly Glu Gln Ile Tyr Gln Arg Val His 
    210                 215                 220                 


Ser Ala Thr Leu Ala Ile Ala Glu Gln His Lys Arg Val Leu Leu Glu 
225                 230                 235                 240 


Met Glu Lys Asn Val Arg Leu Leu Asn Lys Gly Thr Glu His Tyr Ser 
                245                 250                 255     


Tyr Pro Cys Thr Pro Thr Thr Met Leu Pro Arg Ser Ala Tyr Trp His 
            260                 265                 270         


His Ile Thr Gly Ser Gln Asn Ile Ala Glu Ala Ser Ser Tyr Ala Gly 
        275                 280                 285             


Glu Gly Tyr Gly Ala Ala Gln Ala Ser Ser Glu Thr Asp Leu Leu Asn 
    290                 295                 300                 


Arg Phe Ile Leu Leu Lys Pro Lys Pro Ser Gln Gly Asp Ser Ser Glu 
305                 310                 315                 320 


Ala Lys Thr Pro Ser Gln 
                325     


<210>  3216
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOK5__Homo_sapiens__NP_060901

<400>  3216

Met Ala Ser Asn Phe Asn Asp Ile Val Lys Gln Gly Tyr Val Arg Ile 
1               5                   10                  15      


Arg Ser Arg Arg Leu Gly Ile Tyr Gln Arg Cys Trp Leu Val Phe Lys 
            20                  25                  30          


Lys Ala Ser Ser Lys Gly Pro Lys Arg Leu Glu Lys Phe Ser Asp Glu 
        35                  40                  45              


Arg Ala Ala Tyr Phe Arg Cys Tyr His Lys Val Thr Glu Leu Asn Asn 
    50                  55                  60                  


Val Lys Asn Val Ala Arg Leu Pro Lys Ser Thr Lys Lys His Ala Ile 
65                  70                  75                  80  


Gly Ile Tyr Phe Asn Asp Asp Thr Ser Lys Thr Phe Ala Cys Glu Ser 
                85                  90                  95      


Asp Leu Glu Ala Asp Glu Trp Cys Lys Val Leu Gln Met Glu Cys Val 
            100                 105                 110         


Gly Thr Arg Ile Asn Asp Ile Ser Leu Gly Glu Pro Asp Leu Leu Ala 
        115                 120                 125             


Thr Gly Val Glu Arg Glu Gln Ser Glu Arg Phe Asn Val Tyr Leu Met 
    130                 135                 140                 


Pro Ser Pro Asn Leu Asp Val His Gly Glu Cys Ala Leu Gln Ile Thr 
145                 150                 155                 160 


Tyr Glu Tyr Ile Cys Leu Trp Asp Val Gln Asn Pro Arg Val Lys Leu 
                165                 170                 175     


Ile Ser Trp Pro Leu Ser Ala Leu Arg Arg Tyr Gly Arg Asp Thr Thr 
            180                 185                 190         


Trp Phe Thr Phe Glu Ala Gly Arg Met Cys Glu Thr Gly Glu Gly Leu 
        195                 200                 205             


Phe Ile Phe Gln Thr Arg Asp Gly Glu Ala Ile Tyr Gln Lys Val His 
    210                 215                 220                 


Ser Ala Ala Leu Ala Ile Ala Glu Gln His Glu Arg Leu Leu Gln Ser 
225                 230                 235                 240 


Val Lys Asn Ser Met Leu Gln Met Lys Met Ser Glu Arg Ala Ala Ser 
                245                 250                 255     


Leu Ser Thr Met Val Pro Leu Pro Arg Ser Ala Tyr Trp Gln His Ile 
            260                 265                 270         


Thr Arg Gln His Ser Thr Gly Gln Leu Tyr Arg Leu Gln Asp Val Ser 
        275                 280                 285             


Ser Pro Leu Lys Leu His Arg Thr Glu Thr Phe Pro Ala Tyr Arg Ser 
    290                 295                 300                 


Glu His 
305     


<210>  3217
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOK6__Homo_sapiens__NP_689934

<400>  3217

Met Ala Ser Asn Phe Asn Asp Ile Val Lys Gln Gly Tyr Val Lys Ile 
1               5                   10                  15      


Arg Ser Arg Lys Leu Gly Ile Phe Arg Arg Cys Trp Leu Val Phe Lys 
            20                  25                  30          


Lys Ala Ser Ser Lys Gly Pro Arg Arg Leu Glu Lys Phe Pro Asp Glu 
        35                  40                  45              


Lys Ala Ala Tyr Phe Arg Asn Phe His Lys Val Thr Glu Leu His Asn 
    50                  55                  60                  


Ile Lys Asn Ile Thr Arg Leu Pro Arg Glu Thr Lys Lys His Ala Val 
65                  70                  75                  80  


Ala Ile Ile Phe His Asp Glu Thr Ser Lys Thr Phe Ala Cys Glu Ser 
                85                  90                  95      


Glu Leu Glu Ala Glu Glu Trp Cys Lys His Leu Cys Met Glu Cys Leu 
            100                 105                 110         


Gly Thr Arg Leu Asn Asp Ile Ser Leu Gly Glu Pro Asp Leu Leu Ala 
        115                 120                 125             


Ala Gly Val Gln Arg Glu Gln Asn Glu Arg Phe Asn Val Tyr Leu Met 
    130                 135                 140                 


Pro Thr Pro Asn Leu Asp Ile Tyr Gly Glu Cys Thr Met Gln Ile Thr 
145                 150                 155                 160 


His Glu Asn Ile Tyr Leu Trp Asp Ile His Asn Ala Lys Val Lys Leu 
                165                 170                 175     


Val Met Trp Pro Leu Ser Ser Leu Arg Arg Tyr Gly Arg Asp Ser Thr 
            180                 185                 190         


Trp Phe Thr Phe Glu Ser Gly Arg Met Cys Asp Thr Gly Glu Gly Leu 
        195                 200                 205             


Phe Thr Phe Gln Thr Arg Glu Gly Glu Met Ile Tyr Gln Lys Val His 
    210                 215                 220                 


Ser Ala Thr Leu Ala Ile Ala Glu Gln His Glu Arg Leu Met Leu Glu 
225                 230                 235                 240 


Met Glu Gln Lys Ala Arg Leu Gln Thr Ser Leu Thr Glu Pro Met Thr 
                245                 250                 255     


Leu Ser Lys Ser Ile Ser Leu Pro Arg Ser Ala Tyr Trp His His Ile 
            260                 265                 270         


Thr Arg Gln Asn Ser Val Gly Glu Ile Tyr Ser Leu Gln Gly His Gly 
        275                 280                 285             


Phe Gly Ser Ser Lys Met Ser Arg Ala Gln Thr Phe Pro Ser Tyr Ala 
    290                 295                 300                 


Pro Glu Gln Ser Glu Glu Ala Gln Gln Pro Leu Ser Arg Ser Ser Ser 
305                 310                 315                 320 


Tyr Gly Phe Ser Tyr Ser Ser Ser Leu Ile Gln 
                325                 330     


<210>  3218
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOK7__Homo_sapiens__NP_001158145

<400>  3218

Met Thr Glu Ala Ala Leu Val Glu Gly Gln Val Lys Leu Arg Asp Gly 
1               5                   10                  15      


Lys Lys Trp Lys Ser Arg Trp Leu Val Leu Arg Lys Pro Ser Pro Val 
            20                  25                  30          


Ala Asp Cys Leu Leu Met Leu Val Tyr Lys Asp Lys Ser Glu Arg Ile 
        35                  40                  45              


Lys Gly Leu Arg Glu Arg Ser Ser Leu Thr Leu Glu Asp Ile Cys Gly 
    50                  55                  60                  


Leu Glu Pro Gly Leu Pro Tyr Glu Gly Leu Val His Thr Leu Ala Ile 
65                  70                  75                  80  


Val Cys Leu Ser Gln Ala Ile Met Leu Gly Phe Asp Ser His Glu Ala 
                85                  90                  95      


Met Cys Ala Trp Asp Ala Arg Ile Arg Tyr Ala Leu Gly Glu Val His 
            100                 105                 110         


Arg Phe His Val Thr Val Ala Pro Gly Thr Lys Leu Glu Ser Gly Pro 
        115                 120                 125             


Ala Thr Leu His Leu Cys Asn Asp Val Leu Val Leu Ala Arg Asp Ile 
    130                 135                 140                 


Pro Pro Ala Val Thr Gly Gln Trp Lys Leu Ser Asp Leu Arg Arg Tyr 
145                 150                 155                 160 


Gly Ala Val Pro Ser Gly Phe Ile Phe Glu Gly Gly Thr Arg Gly Trp 
                165                 170                 175     


Arg Leu Leu Pro Val Leu Gly Arg Gly Gly Ala Asp Gln Leu Pro Val 
            180                 185                 190         


Arg Leu His Arg Pro Arg His Leu Pro His Gln Gly Pro Leu Trp Ala 
        195                 200                 205             


Ala Ala Gly Ser Thr Arg Pro Lys Ser Pro Gly Thr Leu Asp Cys Gly 
    210                 215                 220                 


Gly Ala Cys Gly Pro Gly Ser Pro Gly Asn Pro Thr Ala Gly Glu Ala 
225                 230                 235                 240 


Ala Glu Pro Pro Leu Thr Cys Gly Gln Ala Gly Gln Trp Arg Gly 
                245                 250                 255 


<210>  3219
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOLK__Homo_sapiens__NP_055723

<400>  3219

Met Thr Arg Glu Cys Pro Ser Pro Ala Pro Gly Pro Gly Ala Pro Leu 
1               5                   10                  15      


Ser Gly Ser Val Leu Ala Glu Ala Ala Val Val Phe Ala Val Val Leu 
            20                  25                  30          


Ser Ile His Ala Thr Val Trp Asp Arg Tyr Ser Trp Cys Ala Val Ala 
        35                  40                  45              


Leu Ala Val Gln Ala Phe Tyr Val Gln Tyr Lys Trp Asp Arg Leu Leu 
    50                  55                  60                  


Gln Gln Gly Ser Ala Val Phe Gln Phe Arg Met Ser Ala Asn Ser Gly 
65                  70                  75                  80  


Leu Leu Pro Ala Ser Met Val Met Pro Leu Leu Gly Leu Val Met Lys 
                85                  90                  95      


Glu Arg Cys Gln Thr Ala Gly Asn Pro Phe Phe Glu Arg Phe Gly Ile 
            100                 105                 110         


Val Val Ala Ala Thr Gly Met Ala Val Ala Leu Phe Ser Ser Val Leu 
        115                 120                 125             


Ala Leu Gly Ile Thr Arg Pro Val Pro Thr Asn Thr Cys Val Ile Leu 
    130                 135                 140                 


Gly Leu Ala Gly Gly Val Ile Ile Tyr Ile Met Lys His Ser Leu Ser 
145                 150                 155                 160 


Val Gly Glu Val Ile Glu Val Leu Glu Val Leu Leu Ile Phe Val Tyr 
                165                 170                 175     


Leu Asn Met Ile Leu Leu Tyr Leu Leu Pro Arg Cys Phe Thr Pro Gly 
            180                 185                 190         


Glu Ala Leu Leu Val Leu Gly Gly Ile Ser Phe Val Leu Asn Gln Leu 
        195                 200                 205             


Ile Lys Arg Ser Leu Thr Leu Val Glu Ser Gln Gly Asp Pro Val Asp 
    210                 215                 220                 


Phe Phe Leu Leu Val Val Val Val Gly Met Val Leu Met Gly Ile Phe 
225                 230                 235                 240 


Phe Ser Thr Leu Phe Val Phe Met Asp Ser Gly Thr Trp Ala Ser Ser 
                245                 250                 255     


Ile Phe Phe His Leu Met Thr Cys Val Leu Ser Leu Gly Val Val Leu 
            260                 265                 270         


Pro Trp Leu His Arg Leu Ile Arg Arg Asn Pro Leu Leu Trp Leu Leu 
        275                 280                 285             


Gln Phe Leu Phe Gln Thr Asp Thr Arg Ile Tyr Leu Leu Ala Tyr Trp 
    290                 295                 300                 


Ser Leu Leu Ala Thr Leu Ala Cys Leu Val Val Leu Tyr Gln Asn Ala 
305                 310                 315                 320 


Lys Arg Ser Ser Ser Glu Ser Lys Lys His Gln Ala Pro Thr Ile Ala 
                325                 330                 335     


Arg Lys Tyr Phe His Leu Ile Val Val Ala Thr Tyr Ile Pro Gly Ile 
            340                 345                 350         


Ile Phe Asp Arg Pro Leu Leu Tyr Val Ala Ala Thr Val Cys Leu Ala 
        355                 360                 365             


Val Phe Ile Phe Leu Glu Tyr Val Arg Tyr Phe Arg Ile Lys Pro Leu 
    370                 375                 380                 


Gly His Thr Leu Arg Ser Phe Leu Ser Leu Phe Leu Asp Glu Arg Asp 
385                 390                 395                 400 


Ser Gly Pro Leu Ile Leu Thr His Ile Tyr Leu Leu Leu Gly Met Ser 
                405                 410                 415     


Leu Pro Ile Trp Leu Ile Pro Arg Pro Cys Thr Gln Lys Gly Ser Leu 
            420                 425                 430         


Gly Gly Ala Arg Ala Leu Val Pro Tyr Ala Gly Val Leu Ala Val Gly 
        435                 440                 445             


Val Gly Asp Thr Val Ala Ser Ile Phe Gly Ser Thr Met Gly Glu Ile 
    450                 455                 460                 


Arg Trp Pro Gly Thr Lys Lys Thr Phe Glu Gly Thr Met Thr Ser Ile 
465                 470                 475                 480 


Phe Ala Gln Ile Ile Ser Val Ala Leu Ile Leu Ile Phe Asp Ser Gly 
                485                 490                 495     


Val Asp Leu Asn Tyr Ser Tyr Ala Trp Ile Leu Gly Ser Ile Ser Thr 
            500                 505                 510         


Val Ser Leu Leu Glu Ala Tyr Thr Thr Gln Ile Asp Asn Leu Leu Leu 
        515                 520                 525             


Pro Leu Tyr Leu Leu Ile Leu Leu Met Ala 
    530                 535             


<210>  3220
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DONSON__Homo_sapiens__NP_060083

<400>  3220

Met Ala Leu Ser Val Pro Gly Tyr Ser Pro Gly Phe Arg Lys Pro Pro 
1               5                   10                  15      


Glu Val Val Arg Leu Arg Arg Lys Arg Ala Arg Ser Arg Gly Ala Ala 
            20                  25                  30          


Ala Ser Pro Pro Arg Glu Leu Thr Glu Pro Ala Ala Arg Arg Ala Ala 
        35                  40                  45              


Leu Val Ala Gly Leu Pro Leu Arg Pro Phe Pro Ala Ala Gly Gly Arg 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Pro Ala Ala Ala Arg Arg Asn Pro Phe 
65                  70                  75                  80  


Ala Arg Leu Asp Asn Arg Pro Arg Val Ala Ala Glu Pro Pro Asp Gly 
                85                  90                  95      


Pro Ala Arg Glu Gln Pro Glu Ala Pro Val Pro Phe Leu Asp Ser Asn 
            100                 105                 110         


Gln Glu Asn Asp Leu Leu Trp Glu Glu Lys Phe Pro Glu Arg Thr Thr 
        115                 120                 125             


Val Thr Glu Leu Pro Gln Thr Ser His Val Ser Phe Ser Glu Pro Asp 
    130                 135                 140                 


Ile Pro Ser Ser Lys Ser Thr Glu Leu Pro Val Asp Trp Ser Ile Lys 
145                 150                 155                 160 


Thr Arg Leu Leu Phe Thr Ser Ser Gln Pro Phe Thr Trp Ala Asp His 
                165                 170                 175     


Leu Lys Ala Gln Glu Glu Ala Gln Gly Leu Val Gln His Cys Arg Ala 
            180                 185                 190         


Thr Glu Val Thr Leu Pro Lys Ser Ile Gln Asp Pro Lys Leu Ser Ser 
        195                 200                 205             


Glu Leu Arg Cys Thr Phe Gln Gln Ser Leu Ile Tyr Trp Leu His Pro 
    210                 215                 220                 


Ala Leu Ser Trp Leu Pro Leu Phe Pro Arg Ile Gly Ala Asp Arg Lys 
225                 230                 235                 240 


Met Ala Gly Lys Thr Ser Pro Trp Ser Asn Asp Ala Thr Leu Gln His 
                245                 250                 255     


Val Leu Met Ser Asp Trp Ser Val Ser Phe Thr Ser Leu Tyr Asn Leu 
            260                 265                 270         


Leu Lys Thr Lys Leu Cys Pro Tyr Phe Tyr Val Cys Thr Tyr Gln Phe 
        275                 280                 285             


Thr Val Leu Phe Arg Ala Ala Gly Leu Ala Gly Ser Asp Leu Ile Thr 
    290                 295                 300                 


Ala Leu Ile Ser Pro Thr Thr Arg Gly Leu Arg Glu Ala Met Arg Asn 
305                 310                 315                 320 


Glu Gly Ile Glu Phe Ser Leu Pro Leu Ile Lys Glu Ser Gly His Lys 
                325                 330                 335     


Lys Glu Thr Ala Ser Gly Thr Ser Leu Gly Tyr Gly Glu Glu Gln Ala 
            340                 345                 350         


Ile Ser Asp Glu Asp Glu Glu Glu Ser Phe Ser Trp Leu Glu Glu Met 
        355                 360                 365             


Gly Val Gln Asp Lys Ile Lys Lys Pro Asp Ile Leu Ser Ile Lys Leu 
    370                 375                 380                 


Arg Lys Glu Lys His Glu Val Gln Met Asp His Arg Pro Glu Ser Val 
385                 390                 395                 400 


Val Leu Val Lys Gly Ile Asn Thr Phe Thr Leu Leu Asn Phe Leu Ile 
                405                 410                 415     


Asn Ser Lys Ser Leu Val Ala Thr Ser Gly Pro Gln Ala Gly Leu Pro 
            420                 425                 430         


Pro Thr Leu Leu Ser Pro Val Ala Phe Arg Gly Ala Thr Met Gln Met 
        435                 440                 445             


Leu Lys Ala Arg Ser Val Asn Val Lys Thr Gln Ala Leu Ser Gly Tyr 
    450                 455                 460                 


Arg Asp Gln Phe Ser Leu Glu Ile Thr Gly Pro Ile Met Pro His Ser 
465                 470                 475                 480 


Leu His Ser Leu Thr Met Leu Leu Lys Ser Ser Gln Ser Gly Ser Phe 
                485                 490                 495     


Ser Ala Val Leu Tyr Pro His Glu Pro Thr Ala Val Phe Asn Ile Cys 
            500                 505                 510         


Leu Gln Met Asp Lys Val Leu Asp Met Glu Val Val His Lys Glu Leu 
        515                 520                 525             


Thr Asn Cys Gly Leu His Pro Asn Thr Leu Glu Gln Leu Ser Gln Ile 
    530                 535                 540                 


Pro Leu Leu Gly Lys Ser Ser Leu Arg Asn Val Val Leu Arg Asp Tyr 
545                 550                 555                 560 


Ile Tyr Asn Trp Arg Ser 
                565     


<210>  3221
<211>  2298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOPEY2__Homo_sapiens__NP_001307643

<400>  3221

Met Asp Pro Glu Glu Gln Glu Leu Leu Asn Asp Tyr Arg Tyr Arg Ser 
1               5                   10                  15      


Tyr Ser Ser Val Ile Glu Lys Ala Leu Arg Asn Phe Glu Ser Ser Ser 
            20                  25                  30          


Glu Trp Ala Asp Leu Ile Ser Ser Leu Gly Lys Leu Asn Lys Ala Leu 
        35                  40                  45              


Gln Ser Asn Leu Arg Tyr Ser Leu Leu Pro Arg Arg Leu Leu Ile Ser 
    50                  55                  60                  


Lys Arg Leu Ala Gln Cys Leu His Pro Ala Leu Pro Ser Gly Val His 
65                  70                  75                  80  


Leu Lys Ala Leu Glu Thr Tyr Glu Ile Ile Phe Lys Ile Val Gly Thr 
                85                  90                  95      


Lys Trp Leu Ala Lys Asp Leu Phe Leu Tyr Ser Cys Gly Leu Phe Pro 
            100                 105                 110         


Leu Leu Ala His Ala Ala Val Ser Val Arg Pro Val Leu Leu Thr Leu 
        115                 120                 125             


Tyr Glu Lys Tyr Phe Leu Pro Leu Gln Lys Leu Leu Leu Pro Ser Leu 
    130                 135                 140                 


Gln Ala Phe Ile Val Gly Leu Leu Pro Gly Leu Glu Glu Gly Ser Glu 
145                 150                 155                 160 


Ile Ser Asp Arg Thr Asp Ala Leu Leu Leu Arg Leu Ser Leu Val Val 
                165                 170                 175     


Gly Lys Glu Val Phe Tyr Thr Ala Leu Trp Gly Ser Val Leu Ala Ser 
            180                 185                 190         


Pro Ser Ile Arg Leu Pro Ala Ser Val Phe Val Val Gly His Ile Asn 
        195                 200                 205             


Arg Asp Ala Pro Gly Arg Glu Gln Lys Tyr Met Leu Gly Thr Asn His 
    210                 215                 220                 


Gln Leu Thr Val Lys Ser Leu Arg Ala Ser Leu Leu Asp Ser Asn Val 
225                 230                 235                 240 


Leu Val Gln Arg Asn Asn Leu Glu Ile Val Leu Phe Phe Phe Pro Phe 
                245                 250                 255     


Tyr Thr Cys Leu Asp Ser Asn Glu Arg Ala Ile Pro Leu Leu Arg Ser 
            260                 265                 270         


Asp Ile Val Arg Ile Leu Ser Ala Ala Thr Gln Thr Leu Leu Arg Arg 
        275                 280                 285             


Asp Met Ser Leu Asn Arg Arg Leu Tyr Ala Trp Leu Leu Gly Ser Asp 
    290                 295                 300                 


Ile Lys Gly Asn Thr Val Val Pro Glu Ser Glu Ile Ser Asn Ser Tyr 
305                 310                 315                 320 


Glu Asp Gln Ser Ser Tyr Phe Phe Glu Lys Tyr Ser Lys Asp Leu Leu 
                325                 330                 335     


Val Glu Gly Leu Ala Glu Ile Leu His Gln Lys Phe Ile Asp Ala Asp 
            340                 345                 350         


Val Glu Glu Arg His His Ala Tyr Leu Lys Pro Phe Arg Val Leu Ile 
        355                 360                 365             


Ser Leu Leu Asp Lys Pro Glu Ile Gly Pro Gln Val Val Gly Asn Leu 
    370                 375                 380                 


Phe Leu Glu Val Ile Arg Ala Phe Tyr Ser Tyr Cys Arg Asp Ala Leu 
385                 390                 395                 400 


Gly Ser Asp Leu Lys Leu Ser Tyr Thr Gln Ser Gly Asn Ser Leu Ile 
                405                 410                 415     


Ser Ala Ile Lys Glu Asn Arg Asn Ala Ser Glu Ile Val Lys Thr Val 
            420                 425                 430         


Asn Leu Leu Ile Thr Ser Leu Ser Thr Asp Phe Leu Trp Asp Tyr Met 
        435                 440                 445             


Thr Arg Cys Phe Glu Glu Cys Phe Arg Pro Val Lys Gln Arg Tyr Ser 
    450                 455                 460                 


Val Arg Asn Ser Val Ser Pro Pro Pro Thr Val Ser Glu Leu Cys Ala 
465                 470                 475                 480 


Leu Leu Val Phe Leu Leu Asp Val Ile Pro Leu Glu Leu Tyr Ser Glu 
                485                 490                 495     


Val Gln Thr Gln Tyr Leu Pro Gln Val Leu Gly Cys Leu Val Gln Pro 
            500                 505                 510         


Leu Ala Glu Asp Met Glu Ala Leu Ser Leu Pro Glu Leu Thr His Ala 
        515                 520                 525             


Leu Lys Thr Cys Phe Lys Val Leu Ser Lys Val Gln Met Pro Pro Ser 
    530                 535                 540                 


Tyr Leu Asp Thr Glu Ser Thr Ser Gly Thr Ser Ser Pro Val Lys Gly 
545                 550                 555                 560 


Glu Asn Gly Lys Ile Ile Leu Glu Thr Lys Ala Val Ile Pro Gly Asp 
                565                 570                 575     


Glu Asp Ala Ser Phe Pro Pro Leu Lys Ser Glu Asp Ser Gly Ile Gly 
            580                 585                 590         


Leu Ser Ala Ser Ser Pro Glu Leu Ser Glu His Leu Arg Val Pro Arg 
        595                 600                 605             


Val Ser Leu Glu Arg Asp Asp Val Trp Lys Lys Gly Gly Ser Met Gln 
    610                 615                 620                 


Arg Thr Phe Leu Cys Ile Gln Glu Leu Ile Ala Asn Phe Ala Ser Lys 
625                 630                 635                 640 


Asn Ile Phe Gly Val Gln Leu Thr Ala Ser Gly Glu Glu Ser Lys Ser 
                645                 650                 655     


Glu Glu Pro Ala Gly Lys Arg Asp Arg Asp Gly Thr Gln Ser Leu Ala 
            660                 665                 670         


Ala Asn Asp Ser Ser Arg Lys Asn Ser Trp Glu Pro Lys Pro Ile Thr 
        675                 680                 685             


Val Pro Gln Phe Lys Gln Met Leu Ser Asp Leu Phe Thr Ala Arg Gly 
    690                 695                 700                 


Ser Pro Phe Lys Thr Lys Ser Ser Glu Ser Pro Ser Ser Ser Pro Ser 
705                 710                 715                 720 


Ser Pro Ala Arg Lys Asn Gly Gly Glu Trp Asp Val Glu Lys Val Val 
                725                 730                 735     


Ile Asp Leu Gly Gly Ser Arg Glu Glu Arg Arg Glu Ala Phe Ala Ala 
            740                 745                 750         


Ala Cys His Leu Leu Leu Asp Cys Ala Thr Phe Pro Val Tyr Leu Ser 
        755                 760                 765             


Glu Glu Glu Thr Glu Gln Leu Cys Ala Thr Leu Phe Gln Leu Pro Gly 
    770                 775                 780                 


Ala Gly Asp Ser Ser Phe Pro Ser Trp Leu Lys Ser Leu Met Thr Ile 
785                 790                 795                 800 


Cys Cys Cys Val Thr Asp Cys Tyr Leu Gln Asn Val Ala Ile Ser Thr 
                805                 810                 815     


Leu Leu Glu Val Ile Asn His Ser Gln Ser Leu Ala Leu Val Ile Glu 
            820                 825                 830         


Asp Lys Met Lys Arg Tyr Lys Ser Ser Gly His Asn Pro Phe Phe Gly 
        835                 840                 845             


Lys Leu Gln Met Val Thr Val Pro Pro Ile Ala Pro Gly Ile Leu Lys 
    850                 855                 860                 


Val Ile Ala Glu Lys Thr Asp Phe Tyr Gln Arg Val Ala Arg Val Leu 
865                 870                 875                 880 


Trp Asn Gln Leu Asn Lys Glu Thr Arg Glu His His Val Thr Cys Val 
                885                 890                 895     


Glu Leu Phe Tyr Arg Leu His Cys Leu Ala Pro Thr Ala Asn Ile Cys 
            900                 905                 910         


Glu Asp Ile Ile Cys His Ala Leu Leu Asp Pro Asp Lys Gly Thr Arg 
        915                 920                 925             


Leu Glu Ala Leu Phe Arg Phe Ser Val Ile Trp His Leu Thr Arg Glu 
    930                 935                 940                 


Ile Gln Gly Ser Arg Val Thr Ser His Asn Arg Ser Phe Asp Arg Ser 
945                 950                 955                 960 


Leu Phe Val Val Leu Asp Ser Leu Ala Cys Thr Asp Gly Ala Ile Gly 
                965                 970                 975     


Ala Ala Ala Gln Gly Trp Leu Val Arg Ala Leu Ser Leu Gly Asp Val 
            980                 985                 990         


Ala Arg Ile Leu Glu Pro Val Leu  Leu Leu Leu Leu Gln  Pro Lys Thr 
        995                 1000                 1005             


Gln Arg  Thr Ser Ile His Cys  Leu Lys Gln Glu Asn  Ser Ala Asp 
    1010                 1015                 1020             


Asp Leu  His Arg Trp Phe Asn  Arg Lys Lys Thr Ser  Phe Arg Glu 
    1025                 1030                 1035             


Ala Cys  Ala Val Pro Glu Pro  Gln Glu Ser Gly Ser  Glu Glu His 
    1040                 1045                 1050             


Leu Pro  Leu Ser Gln Phe Thr  Thr Val Asp Arg Glu  Ala Ile Trp 
    1055                 1060                 1065             


Ala Glu  Val Glu Lys Glu Pro  Glu Lys Tyr Pro Leu  Arg Gly Glu 
    1070                 1075                 1080             


Leu Ser  Glu Glu Glu Leu Pro  Tyr Tyr Val Glu Leu  Pro Asp Arg 
    1085                 1090                 1095             


Thr Ala  His Gly Ala Pro Asp  Ser Ser Glu His Thr  Glu Ser Ala 
    1100                 1105                 1110             


Asp Thr  Ser Ser Cys His Thr  Asp Ser Glu Asn Thr  Ser Ser Phe 
    1115                 1120                 1125             


Ser Ser  Pro Ser His Asp Leu  Gln Glu Leu Ser Asn  Glu Glu Asn 
    1130                 1135                 1140             


Cys Cys  Ala Pro Ile Pro Met  Gly Gly Arg Ala Tyr  Pro Lys Arg 
    1145                 1150                 1155             


Ser Ala  Leu Leu Ala Ala Phe  Gln Ser Glu Ser Phe  Lys Ala Gly 
    1160                 1165                 1170             


Ala Lys  Leu Ser Leu Val Arg  Val Asp Ser Asp Lys  Thr Gln Ala 
    1175                 1180                 1185             


Ser Glu  Ser Phe Ser Ser Asp  Glu Glu Ala Asp Leu  Glu Leu Gln 
    1190                 1195                 1200             


Ala Leu  Thr Thr Ser Arg Leu  Leu Lys Gln Gln Arg  Glu Arg Gln 
    1205                 1210                 1215             


Glu Ala  Val Glu Ala Leu Phe  Lys His Ile Leu Leu  Tyr Leu Gln 
    1220                 1225                 1230             


Pro Tyr  Asp Ser Arg Arg Val  Leu Tyr Ala Phe Ser  Val Leu Glu 
    1235                 1240                 1245             


Ala Val  Leu Lys Thr Asn Pro  Lys Glu Phe Ile Glu  Ala Val Ser 
    1250                 1255                 1260             


Arg Thr  Ser Met Asp Thr Ser  Ser Thr Ala His Leu  Asn Leu Ile 
    1265                 1270                 1275             


Ser Asn  Leu Leu Ala Arg His  Gln Glu Ala Leu Ile  Gly Gln Ser 
    1280                 1285                 1290             


Phe Tyr  Gly Lys Leu Gln Thr  Gln Val Pro Asn Val  Cys Pro His 
    1295                 1300                 1305             


Ser Leu  Leu Leu Glu Leu Leu  Thr Tyr Leu Cys Leu  Ser Phe Leu 
    1310                 1315                 1320             


Arg Ser  Tyr Tyr Pro Cys Tyr  Leu Lys Val Ser His  Arg Asp Ile 
    1325                 1330                 1335             


Leu Gly  Asn Arg Asp Val Gln  Val Lys Ser Val Glu  Val Leu Ile 
    1340                 1345                 1350             


Arg Ile  Met Met Gln Leu Val  Ser Val Ala Lys Ser  Ser Glu Gly 
    1355                 1360                 1365             


Lys Asn  Val Glu Phe Ile His  Ser Leu Leu Gln Arg  Cys Lys Val 
    1370                 1375                 1380             


Gln Glu  Phe Val Leu Leu Ser  Leu Ser Ala Ser Met  Tyr Thr Ser 
    1385                 1390                 1395             


Gln Lys  Arg Tyr Gly Leu Ala  Thr Ala His His Gly  Arg Ala Leu 
    1400                 1405                 1410             


Pro Glu  Asp Ser Leu Phe Glu  Glu Ser Leu Ile Asn  Leu Gly Gln 
    1415                 1420                 1425             


Asp Gln  Ile Trp Ser Glu His  Pro Leu Gln Ile Glu  Leu Leu Lys 
    1430                 1435                 1440             


Leu Leu  Gln Val Leu Ile Val  Leu Glu His His Leu  Gly Arg Ala 
    1445                 1450                 1455             


His Glu  Glu Ala Glu Asn Gln  Pro Asp Leu Ser Arg  Glu Trp Gln 
    1460                 1465                 1470             


Arg Ala  Leu Asn Phe Gln Gln  Ala Ile Ser Ala Leu  Gln Tyr Val 
    1475                 1480                 1485             


Gln Pro  His Pro Leu Thr Ser  Gln Gly Leu Leu Val  Ser Ala Val 
    1490                 1495                 1500             


Val Arg  Gly Leu Gln Pro Ala  Tyr Gly Tyr Gly Met  His Pro Ala 
    1505                 1510                 1515             


Trp Val  Ser Leu Val Thr His  Ser Leu Pro Tyr Phe  Gly Lys Ser 
    1520                 1525                 1530             


Leu Gly  Trp Thr Val Thr Pro  Phe Val Val Gln Ile  Cys Lys Asn 
    1535                 1540                 1545             


Leu Asp  Asp Leu Val Lys Gln  Tyr Glu Ser Glu Ser  Val Lys Leu 
    1550                 1555                 1560             


Ser Val  Ser Thr Thr Ser Lys  Arg Glu Asn Ile Ser  Pro Asp Tyr 
    1565                 1570                 1575             


Pro Leu  Thr Leu Leu Glu Gly  Leu Thr Thr Ile Ser  His Phe Cys 
    1580                 1585                 1590             


Leu Leu  Glu Gln Ala Asn Gln  Asn Lys Lys Thr Met  Ala Ala Gly 
    1595                 1600                 1605             


Asp Pro  Ala Asn Leu Arg Asn  Ala Arg Asn Ala Ile  Leu Glu Glu 
    1610                 1615                 1620             


Leu Pro  Arg Thr Val Asn Thr  Met Ala Leu Leu Trp  Asn Val Leu 
    1625                 1630                 1635             


Arg Lys  Glu Glu Thr Gln Lys  Arg Pro Val Asp Leu  Leu Gly Ala 
    1640                 1645                 1650             


Thr Lys  Gly Ser Ser Ser Val  Tyr Phe Lys Thr Thr  Lys Thr Ile 
    1655                 1660                 1665             


Arg Gln  Lys Ile Leu Asp Phe  Leu Asn Pro Leu Thr  Ala His Leu 
    1670                 1675                 1680             


Gly Val  Gln Leu Thr Ala Ala  Val Ala Ala Val Trp  Ser Arg Lys 
    1685                 1690                 1695             


Lys Ala  Gln Arg His Ser Lys  Met Lys Ile Ile Pro  Thr Ala Ser 
    1700                 1705                 1710             


Ala Ser  Gln Leu Thr Leu Val  Asp Leu Val Cys Ala  Leu Ser Thr 
    1715                 1720                 1725             


Leu Gln  Thr Asp Thr Leu Leu  His Leu Val Lys Glu  Val Val Lys 
    1730                 1735                 1740             


Arg Pro  Pro Gln Val Lys Gly  Gly Asp Glu Lys Ser  Pro Leu Val 
    1745                 1750                 1755             


Asp Ile  Pro Val Leu Gln Phe  Cys Tyr Ala Phe Leu  Gln Arg Leu 
    1760                 1765                 1770             


Pro Val  Pro Ala Leu Gln Glu  Asn Phe Ser Ser Leu  Leu Gly Val 
    1775                 1780                 1785             


Leu Lys  Glu Ser Val Gln Leu  Asn Leu Ala Pro Pro  Gly Tyr Phe 
    1790                 1795                 1800             


Leu Leu  Leu Ser Met Leu Asn  Asp Phe Val Thr Arg  Thr Pro Asn 
    1805                 1810                 1815             


Leu Glu  Asn Lys Lys Asp Gln  Lys Asp Leu Gln Glu  Ile Thr Gln 
    1820                 1825                 1830             


Lys Ile  Leu Glu Ala Val Gly  Asn Ile Ala Gly Ser  Ser Leu Glu 
    1835                 1840                 1845             


Gln Thr  Ser Trp Leu Ser Arg  Asn Leu Glu Val Lys  Ala Gln Pro 
    1850                 1855                 1860             


Gln Ala  Ser Leu Glu Glu Ser  Asp Ala Glu Glu Asp  Leu Tyr Asp 
    1865                 1870                 1875             


Ala Ala  Ala Ala Ser Ala Met  Val Ser Ser Ser Ala  Pro Ser Val 
    1880                 1885                 1890             


Tyr Ser  Val Gln Ala Leu Ser  Leu Leu Ala Glu Val  Leu Ala Ser 
    1895                 1900                 1905             


Leu Leu  Asp Met Val Tyr Arg  Ser Asp Glu Lys Glu  Lys Ala Val 
    1910                 1915                 1920             


Pro Leu  Ile Ser Arg Leu Leu  Tyr Tyr Val Phe Pro  Tyr Leu Arg 
    1925                 1930                 1935             


Asn His  Ser Ala Tyr Asn Ala  Pro Ser Phe Arg Ala  Gly Ala Gln 
    1940                 1945                 1950             


Leu Leu  Ser Ser Leu Ser Gly  Tyr Ala Tyr Thr Lys  Arg Ala Trp 
    1955                 1960                 1965             


Arg Lys  Glu Val Leu Glu Leu  Phe Leu Asp Pro Ala  Phe Phe Gln 
    1970                 1975                 1980             


Met Asp  Thr Ser Cys Val His  Trp Lys Ser Ile Ile  Asp His Leu 
    1985                 1990                 1995             


Leu Thr  His Glu Lys Thr Met  Phe Lys Asp Leu Met  Asn Met Gln 
    2000                 2005                 2010             


Ser Ser  Ser Leu Lys Leu Phe  Ser Ser Phe Glu Gln  Lys Ala Met 
    2015                 2020                 2025             


Leu Leu  Lys Arg Gln Ala Phe  Ala Val Phe Ser Gly  Glu Leu Asp 
    2030                 2035                 2040             


Gln Tyr  His Leu Tyr Leu Pro  Leu Ile Gln Glu Arg  Leu Thr Asp 
    2045                 2050                 2055             


Asn Leu  Arg Val Gly Gln Thr  Ser Ile Val Ala Ala  Gln Met Phe 
    2060                 2065                 2070             


Leu Phe  Phe Arg Val Leu Leu  Leu Arg Ile Ser Pro  Gln His Leu 
    2075                 2080                 2085             


Thr Ser  Leu Trp Pro Ile Met  Val Ser Glu Leu Ile  Gln Thr Phe 
    2090                 2095                 2100             


Thr Gln  Leu Glu Glu Asp Leu  Lys Asp Glu Asp Glu  Ser Leu Arg 
    2105                 2110                 2115             


Ser Thr  Asn Lys Val Asn Arg  Thr Lys Val Ser Val  Pro Asp Ala 
    2120                 2125                 2130             


Asn Gly  Pro Ser Val Gly Glu  Ile Pro Gln Ser Glu  Leu Ile Leu 
    2135                 2140                 2145             


Tyr Leu  Ser Ala Cys Lys Phe  Leu Asp Thr Ala Leu  Ser Phe Pro 
    2150                 2155                 2160             


Pro Asp  Lys Met Pro Leu Phe  Gln Ile Tyr Arg Trp  Ala Phe Ile 
    2165                 2170                 2175             


Pro Glu  Val Asp Thr Glu Gly  Pro Ala Phe Leu Ser  Asp Val Glu 
    2180                 2185                 2190             


Glu Asn  His Gln Glu Cys Lys  Pro His Thr Val Arg  Ile Leu Glu 
    2195                 2200                 2205             


Leu Leu  Lys Leu Lys Phe Gly  Glu Ile Ser Ser Ser  Asp Glu Ile 
    2210                 2215                 2220             


Thr Met  Lys Ser Glu Phe Pro  Leu Leu Arg Gln His  Ser Val Ser 
    2225                 2230                 2235             


Ser Ile  Arg Gln Leu Met Pro  Phe Phe Met Thr Leu  Asn Gly Ala 
    2240                 2245                 2250             


Phe Lys  Thr Gln Arg Gln Leu  Pro Ala Asp Ser Pro  Gly Thr Pro 
    2255                 2260                 2265             


Phe Leu  Asp Phe Pro Val Thr  Asp Ser Pro Arg Ile  Leu Lys Gln 
    2270                 2275                 2280             


Leu Glu  Glu Cys Ile Glu Tyr  Asp Phe Leu Glu His  Pro Glu Cys 
    2285                 2290                 2295             


<210>  3222
<211>  1537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DOT1L__Homo_sapiens__NP_115871

<400>  3222

Met Gly Glu Lys Leu Glu Leu Arg Leu Lys Ser Pro Val Gly Ala Glu 
1               5                   10                  15      


Pro Ala Val Tyr Pro Trp Pro Leu Pro Val Tyr Asp Lys His His Asp 
            20                  25                  30          


Ala Ala His Glu Ile Ile Glu Thr Ile Arg Trp Val Cys Glu Glu Ile 
        35                  40                  45              


Pro Asp Leu Lys Leu Ala Met Glu Asn Tyr Val Leu Ile Asp Tyr Asp 
    50                  55                  60                  


Thr Lys Ser Phe Glu Ser Met Gln Arg Leu Cys Asp Lys Tyr Asn Arg 
65                  70                  75                  80  


Ala Ile Asp Ser Ile His Gln Leu Trp Lys Gly Thr Thr Gln Pro Met 
                85                  90                  95      


Lys Leu Asn Thr Arg Pro Ser Thr Gly Leu Leu Arg His Ile Leu Gln 
            100                 105                 110         


Gln Val Tyr Asn His Ser Val Thr Asp Pro Glu Lys Leu Asn Asn Tyr 
        115                 120                 125             


Glu Pro Phe Ser Pro Glu Val Tyr Gly Glu Thr Ser Phe Asp Leu Val 
    130                 135                 140                 


Ala Gln Met Ile Asp Glu Ile Lys Met Thr Asp Asp Asp Leu Phe Val 
145                 150                 155                 160 


Asp Leu Gly Ser Gly Val Gly Gln Val Val Leu Gln Val Ala Ala Ala 
                165                 170                 175     


Thr Asn Cys Lys His His Tyr Gly Val Glu Lys Ala Asp Ile Pro Ala 
            180                 185                 190         


Lys Tyr Ala Glu Thr Met Asp Arg Glu Phe Arg Lys Trp Met Lys Trp 
        195                 200                 205             


Tyr Gly Lys Lys His Ala Glu Tyr Thr Leu Glu Arg Gly Asp Phe Leu 
    210                 215                 220                 


Ser Glu Glu Trp Arg Glu Arg Ile Ala Asn Thr Ser Val Ile Phe Val 
225                 230                 235                 240 


Asn Asn Phe Ala Phe Gly Pro Glu Val Asp His Gln Leu Lys Glu Arg 
                245                 250                 255     


Phe Ala Asn Met Lys Glu Gly Gly Arg Ile Val Ser Ser Lys Pro Phe 
            260                 265                 270         


Ala Pro Leu Asn Phe Arg Ile Asn Ser Arg Asn Leu Ser Asp Ile Gly 
        275                 280                 285             


Thr Ile Met Arg Val Val Glu Leu Ser Pro Leu Lys Gly Ser Val Ser 
    290                 295                 300                 


Trp Thr Gly Lys Pro Val Ser Tyr Tyr Leu His Thr Ile Asp Arg Thr 
305                 310                 315                 320 


Ile Leu Glu Asn Tyr Phe Ser Ser Leu Lys Asn Pro Lys Leu Arg Glu 
                325                 330                 335     


Glu Gln Glu Ala Ala Arg Arg Arg Gln Gln Arg Glu Ser Lys Ser Asn 
            340                 345                 350         


Ala Ala Thr Pro Thr Lys Gly Pro Glu Gly Lys Val Ala Gly Pro Ala 
        355                 360                 365             


Asp Ala Pro Met Asp Ser Gly Ala Glu Glu Glu Lys Ala Gly Ala Ala 
    370                 375                 380                 


Thr Val Lys Lys Pro Ser Pro Ser Lys Ala Arg Lys Lys Lys Leu Asn 
385                 390                 395                 400 


Lys Lys Gly Arg Lys Met Ala Gly Arg Lys Arg Gly Arg Pro Lys Lys 
                405                 410                 415     


Met Asn Thr Ala Asn Pro Glu Arg Lys Pro Lys Lys Asn Gln Thr Ala 
            420                 425                 430         


Leu Asp Ala Leu His Ala Gln Thr Val Ser Gln Thr Ala Ala Ser Ser 
        435                 440                 445             


Pro Gln Asp Ala Tyr Arg Ser Pro His Ser Pro Phe Tyr Gln Leu Pro 
    450                 455                 460                 


Pro Ser Val Gln Arg His Ser Pro Asn Pro Leu Leu Val Ala Pro Thr 
465                 470                 475                 480 


Pro Pro Ala Leu Gln Lys Leu Leu Glu Ser Phe Lys Ile Gln Tyr Leu 
                485                 490                 495     


Gln Phe Leu Ala Tyr Thr Lys Thr Pro Gln Tyr Lys Ala Ser Leu Gln 
            500                 505                 510         


Glu Leu Leu Gly Gln Glu Lys Glu Lys Asn Ala Gln Leu Leu Gly Ala 
        515                 520                 525             


Ala Gln Gln Leu Leu Ser His Cys Gln Ala Gln Lys Glu Glu Ile Arg 
    530                 535                 540                 


Arg Leu Phe Gln Gln Lys Leu Asp Glu Leu Gly Val Lys Ala Leu Thr 
545                 550                 555                 560 


Tyr Asn Asp Leu Ile Gln Ala Gln Lys Glu Ile Ser Ala His Asn Gln 
                565                 570                 575     


Gln Leu Arg Glu Gln Ser Glu Gln Leu Glu Gln Asp Asn Arg Ala Leu 
            580                 585                 590         


Arg Gly Gln Ser Leu Gln Leu Leu Lys Ala Arg Cys Glu Glu Leu Gln 
        595                 600                 605             


Leu Asp Trp Ala Thr Leu Ser Leu Glu Lys Leu Leu Lys Glu Lys Gln 
    610                 615                 620                 


Ala Leu Lys Ser Gln Ile Ser Glu Lys Gln Arg His Cys Leu Glu Leu 
625                 630                 635                 640 


Gln Ile Ser Ile Val Glu Leu Glu Lys Ser Gln Arg Gln Gln Glu Leu 
                645                 650                 655     


Leu Gln Leu Lys Ser Cys Val Pro Pro Asp Asp Ala Leu Ser Leu His 
            660                 665                 670         


Leu Arg Gly Lys Gly Ala Leu Gly Arg Glu Leu Glu Pro Asp Ala Ser 
        675                 680                 685             


Arg Leu His Leu Glu Leu Asp Cys Thr Lys Phe Ser Leu Pro His Leu 
    690                 695                 700                 


Ser Ser Met Ser Pro Glu Leu Ser Met Asn Gly Gln Ala Ala Gly Tyr 
705                 710                 715                 720 


Glu Leu Cys Gly Val Leu Ser Arg Pro Ser Ser Lys Gln Asn Thr Pro 
                725                 730                 735     


Gln Tyr Leu Ala Ser Pro Leu Asp Gln Glu Val Val Pro Cys Thr Pro 
            740                 745                 750         


Ser His Val Gly Arg Pro Arg Leu Glu Lys Leu Ser Gly Leu Ala Ala 
        755                 760                 765             


Pro Asp Tyr Thr Arg Leu Ser Pro Ala Lys Ile Val Leu Arg Arg His 
    770                 775                 780                 


Leu Ser Gln Asp His Thr Val Pro Gly Arg Pro Ala Ala Ser Glu Leu 
785                 790                 795                 800 


His Ser Arg Ala Glu His Thr Lys Glu Asn Gly Leu Pro Tyr Gln Ser 
                805                 810                 815     


Pro Ser Val Pro Gly Ser Met Lys Leu Ser Pro Gln Asp Pro Arg Pro 
            820                 825                 830         


Leu Ser Pro Gly Ala Leu Gln Leu Ala Gly Glu Lys Ser Ser Glu Lys 
        835                 840                 845             


Gly Leu Arg Glu Arg Ala Tyr Gly Ser Ser Gly Glu Leu Ile Thr Ser 
    850                 855                 860                 


Leu Pro Ile Ser Ile Pro Leu Ser Thr Val Gln Pro Asn Lys Leu Pro 
865                 870                 875                 880 


Val Ser Ile Pro Leu Ala Ser Val Val Leu Pro Ser Arg Ala Glu Arg 
                885                 890                 895     


Ala Arg Ser Thr Pro Ser Pro Val Leu Gln Pro Arg Asp Pro Ser Ser 
            900                 905                 910         


Thr Leu Glu Lys Gln Ile Gly Ala Asn Ala His Gly Ala Gly Ser Arg 
        915                 920                 925             


Ser Leu Ala Leu Ala Pro Ala Gly Phe Ser Tyr Ala Gly Ser Val Ala 
    930                 935                 940                 


Ile Ser Gly Ala Leu Ala Gly Ser Pro Ala Ser Leu Thr Pro Gly Ala 
945                 950                 955                 960 


Glu Pro Ala Thr Leu Asp Glu Ser Ser Ser Ser Gly Ser Leu Phe Ala 
                965                 970                 975     


Thr Val Gly Ser Arg Ser Ser Thr Pro Gln His Pro Leu Leu Leu Ala 
            980                 985                 990         


Gln Pro Arg Asn Ser Leu Pro Ala  Ser Pro Ala His Gln  Leu Ser Ser 
        995                 1000                 1005             


Ser Pro  Arg Leu Gly Gly Ala  Ala Gln Gly Pro Leu  Pro Glu Ala 
    1010                 1015                 1020             


Ser Lys  Gly Asp Leu Pro Ser  Asp Ser Gly Phe Ser  Asp Pro Glu 
    1025                 1030                 1035             


Ser Glu  Ala Lys Arg Arg Ile  Val Phe Thr Ile Thr  Thr Gly Ala 
    1040                 1045                 1050             


Gly Ser  Ala Lys Gln Ser Pro  Ser Ser Lys His Ser  Pro Leu Thr 
    1055                 1060                 1065             


Ala Ser  Ala Arg Gly Asp Cys  Val Pro Ser His Gly  Gln Asp Ser 
    1070                 1075                 1080             


Arg Arg  Arg Gly Arg Arg Lys  Arg Ala Ser Ala Gly  Thr Pro Ser 
    1085                 1090                 1095             


Leu Ser  Ala Gly Val Ser Pro  Lys Arg Arg Ala Leu  Pro Ser Val 
    1100                 1105                 1110             


Ala Gly  Leu Phe Thr Gln Pro  Ser Gly Ser Pro Leu  Asn Leu Asn 
    1115                 1120                 1125             


Ser Met  Val Ser Asn Ile Asn  Gln Pro Leu Glu Ile  Thr Ala Ile 
    1130                 1135                 1140             


Ser Ser  Pro Glu Thr Ser Leu  Lys Ser Ser Pro Val  Pro Tyr Gln 
    1145                 1150                 1155             


Asp His  Asp Gln Pro Pro Val  Leu Lys Lys Glu Arg  Pro Leu Ser 
    1160                 1165                 1170             


Gln Thr  Asn Gly Ala His Tyr  Ser Pro Leu Thr Ser  Asp Glu Glu 
    1175                 1180                 1185             


Pro Gly  Ser Glu Asp Glu Pro  Ser Ser Ala Arg Ile  Glu Arg Lys 
    1190                 1195                 1200             


Ile Ala  Thr Ile Ser Leu Glu  Ser Lys Ser Pro Pro  Lys Thr Leu 
    1205                 1210                 1215             


Glu Asn  Gly Gly Gly Leu Ala  Gly Arg Lys Pro Ala  Pro Ala Gly 
    1220                 1225                 1230             


Glu Pro  Val Asn Ser Ser Lys  Trp Lys Ser Thr Phe  Ser Pro Ile 
    1235                 1240                 1245             


Ser Asp  Ile Gly Leu Ala Lys  Ser Ala Asp Ser Pro  Leu Gln Ala 
    1250                 1255                 1260             


Ser Ser  Ala Leu Ser Gln Asn  Ser Leu Phe Thr Phe  Arg Pro Ala 
    1265                 1270                 1275             


Leu Glu  Glu Pro Ser Ala Asp  Ala Lys Leu Ala Ala  His Pro Arg 
    1280                 1285                 1290             


Lys Gly  Phe Pro Gly Ser Leu  Ser Gly Ala Asp Gly  Leu Ser Pro 
    1295                 1300                 1305             


Gly Thr  Asn Pro Ala Asn Gly  Cys Thr Phe Gly Gly  Gly Leu Ala 
    1310                 1315                 1320             


Ala Asp  Leu Ser Leu His Ser  Phe Ser Asp Gly Ala  Ser Leu Pro 
    1325                 1330                 1335             


His Lys  Gly Pro Glu Ala Ala  Gly Leu Ser Ser Pro  Leu Ser Phe 
    1340                 1345                 1350             


Pro Ser  Gln Arg Gly Lys Glu  Gly Ser Asp Ala Asn  Pro Phe Leu 
    1355                 1360                 1365             


Ser Lys  Arg Gln Leu Asp Gly  Leu Ala Gly Leu Lys  Gly Glu Gly 
    1370                 1375                 1380             


Ser Arg  Gly Lys Glu Ala Gly  Glu Gly Gly Leu Pro  Leu Cys Gly 
    1385                 1390                 1395             


Pro Thr  Asp Lys Thr Pro Leu  Leu Ser Gly Lys Ala  Ala Lys Ala 
    1400                 1405                 1410             


Arg Asp  Arg Glu Val Asp Leu  Lys Asn Gly His Asn  Leu Phe Ile 
    1415                 1420                 1425             


Ser Ala  Ala Ala Val Pro Pro  Gly Ser Leu Leu Ser  Gly Pro Gly 
    1430                 1435                 1440             


Leu Ala  Pro Ala Ala Ser Ser  Ala Gly Gly Ala Ala  Ser Ser Ala 
    1445                 1450                 1455             


Gln Thr  His Arg Ser Phe Leu  Gly Pro Phe Pro Pro  Gly Pro Gln 
    1460                 1465                 1470             


Phe Ala  Leu Gly Pro Met Ser  Leu Gln Ala Asn Leu  Gly Ser Val 
    1475                 1480                 1485             


Ala Gly  Ser Ser Val Leu Gln  Ser Leu Phe Ser Ser  Val Pro Ala 
    1490                 1495                 1500             


Ala Ala  Gly Leu Val His Val  Ser Ser Ala Ala Thr  Arg Leu Thr 
    1505                 1510                 1515             


Asn Ser  His Ala Met Gly Ser  Phe Ser Gly Val Ala  Gly Gly Thr 
    1520                 1525                 1530             


Val Gly  Gly Asn 
    1535         


<210>  3223
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPAGT1__Homo_sapiens__NP_001373

<400>  3223

Met Trp Ala Phe Ser Glu Leu Pro Met Pro Leu Leu Ile Asn Leu Ile 
1               5                   10                  15      


Val Ser Leu Leu Gly Phe Val Ala Thr Val Thr Leu Ile Pro Ala Phe 
            20                  25                  30          


Arg Gly His Phe Ile Ala Ala Arg Leu Cys Gly Gln Asp Leu Asn Lys 
        35                  40                  45              


Thr Ser Arg Gln Gln Ile Pro Glu Ser Gln Gly Val Ile Ser Gly Ala 
    50                  55                  60                  


Val Phe Leu Ile Ile Leu Phe Cys Phe Ile Pro Phe Pro Phe Leu Asn 
65                  70                  75                  80  


Cys Phe Val Lys Glu Gln Cys Lys Ala Phe Pro His His Glu Phe Val 
                85                  90                  95      


Ala Leu Ile Gly Ala Leu Leu Ala Ile Cys Cys Met Ile Phe Leu Gly 
            100                 105                 110         


Phe Ala Asp Asp Val Leu Asn Leu Arg Trp Arg His Lys Leu Leu Leu 
        115                 120                 125             


Pro Thr Ala Ala Ser Leu Pro Leu Leu Met Val Tyr Phe Thr Asn Phe 
    130                 135                 140                 


Gly Asn Thr Thr Ile Val Val Pro Lys Pro Phe Arg Pro Ile Leu Gly 
145                 150                 155                 160 


Leu His Leu Asp Leu Gly Ile Leu Tyr Tyr Val Tyr Met Gly Leu Leu 
                165                 170                 175     


Ala Val Phe Cys Thr Asn Ala Ile Asn Ile Leu Ala Gly Ile Asn Gly 
            180                 185                 190         


Leu Glu Ala Gly Gln Ser Leu Val Ile Ser Ala Ser Ile Ile Val Phe 
        195                 200                 205             


Asn Leu Val Glu Leu Glu Gly Asp Cys Arg Asp Asp His Val Phe Ser 
    210                 215                 220                 


Leu Tyr Phe Met Ile Pro Phe Phe Phe Thr Thr Leu Gly Leu Leu Tyr 
225                 230                 235                 240 


His Asn Trp Tyr Pro Ser Arg Val Phe Val Gly Asp Thr Phe Cys Tyr 
                245                 250                 255     


Phe Ala Gly Met Thr Phe Ala Val Val Gly Ile Leu Gly His Phe Ser 
            260                 265                 270         


Lys Thr Met Leu Leu Phe Phe Met Pro Gln Val Phe Asn Phe Leu Tyr 
        275                 280                 285             


Ser Leu Pro Gln Leu Leu His Ile Ile Pro Cys Pro Arg His Arg Ile 
    290                 295                 300                 


Pro Arg Leu Asn Ile Lys Thr Gly Lys Leu Glu Met Ser Tyr Ser Lys 
305                 310                 315                 320 


Phe Lys Thr Lys Ser Leu Ser Phe Leu Gly Thr Phe Ile Leu Lys Val 
                325                 330                 335     


Ala Glu Ser Leu Gln Leu Val Thr Val His Gln Ser Glu Thr Glu Asp 
            340                 345                 350         


Gly Glu Phe Thr Glu Cys Asn Asn Met Thr Leu Ile Asn Leu Leu Leu 
        355                 360                 365             


Lys Val Leu Gly Pro Ile His Glu Arg Asn Leu Thr Leu Leu Leu Leu 
    370                 375                 380                 


Leu Leu Gln Ile Leu Gly Ser Ala Ile Thr Phe Ser Ile Arg Tyr Gln 
385                 390                 395                 400 


Leu Val Arg Leu Phe Tyr Asp Val 
                405             


<210>  3224
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPCD__Homo_sapiens__NP_056263

<400>  3224

Met Ala Val Thr Gly Trp Leu Glu Ser Leu Arg Thr Ala Gln Lys Thr 
1               5                   10                  15      


Ala Leu Leu Gln Asp Gly Arg Arg Lys Val His Tyr Leu Phe Pro Asp 
            20                  25                  30          


Gly Lys Glu Met Ala Glu Glu Tyr Asp Glu Lys Thr Ser Glu Leu Leu 
        35                  40                  45              


Val Arg Lys Trp Arg Val Lys Ser Ala Leu Gly Ala Met Gly Gln Trp 
    50                  55                  60                  


Gln Leu Glu Val Gly Asp Pro Ala Pro Leu Gly Ala Gly Asn Leu Gly 
65                  70                  75                  80  


Pro Glu Leu Ile Lys Glu Ser Asn Ala Asn Pro Ile Phe Met Arg Lys 
                85                  90                  95      


Asp Thr Lys Met Ser Phe Gln Trp Arg Ile Arg Asn Leu Pro Tyr Pro 
            100                 105                 110         


Lys Asp Val Tyr Ser Val Ser Val Asp Gln Lys Glu Arg Cys Ile Ile 
        115                 120                 125             


Val Arg Thr Thr Asn Lys Lys Tyr Tyr Lys Lys Phe Ser Ile Pro Asp 
    130                 135                 140                 


Leu Asp Arg His Gln Leu Pro Leu Asp Asp Ala Leu Leu Ser Phe Ala 
145                 150                 155                 160 


His Ala Asn Cys Thr Leu Ile Ile Ser Tyr Gln Lys Pro Lys Glu Val 
                165                 170                 175     


Val Val Ala Glu Ser Glu Leu Gln Lys Glu Leu Lys Lys Val Lys Thr 
            180                 185                 190         


Ala His Ser Asn Asp Gly Asp Cys Lys Thr Gln 
        195                 200             


<210>  3225
<211>  1393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPCR1__Homo_sapiens__NP_543146

<400>  3225

Met Ala Gln Pro Val His Ser Leu Cys Ser Ala Phe Gly Leu Gln Cys 
1               5                   10                  15      


Cys Leu Leu Phe Leu Leu Ala Ser Trp Gly Ala Gly Ala Thr Thr Phe 
            20                  25                  30          


Gln Glu Tyr Gln Lys Thr Gly Glu Leu Ser Thr Ser Asp His Ile Phe 
        35                  40                  45              


Pro Leu Thr Pro Gly Leu Val Tyr Ser Ile Pro Phe Asp His Ile Val 
    50                  55                  60                  


Leu His Ser Gly Gln Arg Pro Pro Glu Leu Pro Lys Ser Thr Glu Ile 
65                  70                  75                  80  


His Glu Gln Lys Arg His Cys Asn Thr Thr Arg His Ser Lys Pro Thr 
                85                  90                  95      


Asp Lys Pro Thr Gly Asn Ser Lys Thr Ile Asp His Lys Ser Ser Thr 
            100                 105                 110         


Asp Asn His Glu Ala Pro Pro Thr Ser Glu Glu Asn Ser Ser Asn Gln 
        115                 120                 125             


Gly Lys Asp Pro Met Ile Arg Asn Gln Arg Ser Val Asp Pro Ala Asp 
    130                 135                 140                 


Ser Thr Thr Thr His Lys Glu Ser Ala Gly Lys Lys His Ile Thr Pro 
145                 150                 155                 160 


Ala Pro Lys Ser Lys Ile Asn Cys Arg Lys Ser Thr Thr Gly Lys Ser 
                165                 170                 175     


Thr Val Thr Arg Lys Ser Asp Lys Thr Gly Arg Pro Leu Glu Lys Ser 
            180                 185                 190         


Met Ser Thr Leu Asp Lys Thr Ser Thr Ser Ser His Lys Thr Thr Thr 
        195                 200                 205             


Ser Phe His Asn Ser Gly Asn Ser Gln Thr Lys Gln Lys Ser Thr Ser 
    210                 215                 220                 


Phe Pro Glu Lys Ile Thr Ala Ala Ser Lys Thr Thr Tyr Lys Thr Thr 
225                 230                 235                 240 


Gly Thr Pro Glu Glu Ser Glu Lys Thr Glu Asp Ser Arg Thr Thr Val 
                245                 250                 255     


Ala Ser Asp Lys Leu Leu Thr Lys Thr Thr Lys Asn Ile Gln Glu Thr 
            260                 265                 270         


Ile Ser Ala Asn Glu Leu Thr Gln Ser Leu Ala Glu Pro Thr Glu His 
        275                 280                 285             


Gly Gly Arg Thr Ala Asn Glu Asn Asn Thr Pro Ser Pro Ala Glu Pro 
    290                 295                 300                 


Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Leu Ser Pro 
305                 310                 315                 320 


Ala Glu Pro Ile Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Ala 
                325                 330                 335     


Pro Phe Pro Ala Gly Pro Thr Glu Asn Arg Glu Met Thr Ala Asn Glu 
            340                 345                 350         


Asn Thr Thr Leu Phe Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr 
        355                 360                 365             


Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu His Gly 
    370                 375                 380                 


Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr 
385                 390                 395                 400 


Glu His Gly Glu Arg Thr Pro Phe Ala Asn Asp Lys Thr Thr Ser Ser 
                405                 410                 415     


Ser Ala Glu Ser Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn Glu 
            420                 425                 430         


Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr 
        435                 440                 445             


Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Gly Pro Thr Glu Asn Arg 
    450                 455                 460                 


Glu Thr Thr Ala Asn Glu Lys Thr Thr Leu Ser Pro Val Glu Pro Thr 
465                 470                 475                 480 


Glu Asn Arg Glu Thr Thr Ala Asn Glu Lys Thr Thr Pro Ser Pro Ala 
                485                 490                 495     


Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn Glu Lys Thr 
            500                 505                 510         


Thr Ser Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Leu 
        515                 520                 525             


Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg 
    530                 535                 540                 


Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro Ser Pro Ala Glu Pro Thr 
545                 550                 555                 560 


Glu Asn Gly Asp Arg Thr Pro Leu Ala Asn Glu Lys Thr Thr Pro Ser 
                565                 570                 575     


Leu Ala Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn Glu 
            580                 585                 590         


Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Glu Glu Arg Thr 
        595                 600                 605             


Pro Leu Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu 
    610                 615                 620                 


Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Gly 
625                 630                 635                 640 


Pro Thr Glu Asn Arg Glu Met Thr Ala Asn Glu Lys Thr Thr Leu Phe 
                645                 650                 655     


Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr 
            660                 665                 670         


Thr Ser Ser Pro Ala Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe 
        675                 680                 685             


Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Gly 
    690                 695                 700                 


Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Leu Ser Pro Ala Glu 
705                 710                 715                 720 


Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro Phe 
                725                 730                 735     


Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr 
            740                 745                 750         


Thr Pro Ser Pro Ala Gln Pro Thr Glu Asn Gly Asp Arg Thr Pro Leu 
        755                 760                 765             


Ala Asn Glu Lys Thr Thr Pro Ser Leu Ala Glu Pro Thr Glu Asn Gly 
    770                 775                 780                 


Lys Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu 
785                 790                 795                 800 


Pro Thr Glu His Ala Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr 
                805                 810                 815     


Ser Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu 
            820                 825                 830         


Lys Thr Thr Gln Phe Pro Ala Glu Pro Thr Glu Asn Arg Glu Ser Thr 
        835                 840                 845             


Ala Asn Glu Lys Thr Thr Pro Phe Pro Ala Glu Pro Thr Glu Asn Arg 
    850                 855                 860                 


Glu Trp Thr Ala Asn Glu Asn Thr Thr Leu Ser Pro Ala Glu Pro Thr 
865                 870                 875                 880 


Glu His Glu Glu Met Thr Pro Leu Ala Asn Glu Lys Thr Thr Leu Ser 
                885                 890                 895     


Pro Ala Glu Pro Thr Glu Asn Gly Glu Arg Thr Pro Phe Thr Asn Glu 
            900                 905                 910         


Lys Thr Thr Pro Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr 
        915                 920                 925             


Pro Leu Ala Asn Glu Ile Thr Thr Pro Ser Arg Ala Glu Pro Thr Glu 
    930                 935                 940                 


His Gly Glu Arg Ile Ala Asn Glu Lys Ala Thr Pro Ser Pro Ala Lys 
945                 950                 955                 960 


Pro Thr Glu His Gly Glu Thr Thr Val Asn Glu Asp Thr Thr Pro Ser 
                965                 970                 975     


Ser Ala Glu Pro Thr Glu Asn Gly Glu Arg Thr Pro Leu Ala Asn Glu 
            980                 985                 990         


Asn Thr Thr Thr Ser Pro Thr Glu  Ser Thr Glu His Gly  Glu Arg Thr 
        995                 1000                 1005             


Ala Asn  Glu Lys Thr Thr Pro  Ser Pro Ala Glu Pro  Thr Glu His 
    1010                 1015                 1020             


Gly Glu  Arg Thr Pro Ser Ala  Asn Glu Lys Thr Ile  Pro Ser Pro 
    1025                 1030                 1035             


Ala Lys  Pro Thr Glu His Glu  Glu Met Thr Pro Ser  Ala Asn Glu 
    1040                 1045                 1050             


Asn Thr  Thr Pro Ser Pro Val  Lys Pro Thr Glu His  Gly Glu Lys 
    1055                 1060                 1065             


Thr Thr  Leu Ala Asn Glu Lys  Ile Thr Leu Ser Pro  Glu Gly Pro 
    1070                 1075                 1080             


Thr Glu  His Gly Ala Lys Thr  Thr Ser Ala Asn Glu  Lys Ile Thr 
    1085                 1090                 1095             


Pro Ser  Leu Ala Lys Pro Thr  Glu His Gly Glu Arg  Thr Thr Ser 
    1100                 1105                 1110             


Pro Asn  Asp Lys Ile Thr Ser  Ser Ala Ala Glu Ser  Thr Glu His 
    1115                 1120                 1125             


Arg Asp  Arg Ala Thr Ser Ala  Asn Val Ile Thr Pro  Ala Pro Ala 
    1130                 1135                 1140             


Glu Pro  Ile Lys His Ala Lys  Arg Thr Thr Leu Ala  His Glu Lys 
    1145                 1150                 1155             


Met Thr  Gln Val Thr Glu Lys  Ser Thr Glu His Pro  Glu Lys Thr 
    1160                 1165                 1170             


Thr Ser  Thr Thr Glu Lys Thr  Thr Arg Thr Pro Glu  Lys Pro Thr 
    1175                 1180                 1185             


Leu Tyr  Ser Glu Lys Thr Ile  Cys Thr Lys Gly Lys  Asn Thr Pro 
    1190                 1195                 1200             


Val Pro  Glu Lys Pro Thr Glu  Asn Leu Gly Asn Thr  Thr Leu Thr 
    1205                 1210                 1215             


Thr Glu  Thr Ile Lys Ala Pro  Val Lys Ser Thr Glu  Asn Pro Glu 
    1220                 1225                 1230             


Lys Thr  Ala Ala Val Thr Lys  Thr Ile Lys Pro Ser  Val Lys Val 
    1235                 1240                 1245             


Thr Gly  Asp Lys Ser Leu Thr  Thr Thr Ser Ser His  Leu Asn Lys 
    1250                 1255                 1260             


Thr Glu  Val Thr His Gln Val  Pro Thr Gly Ser Phe  Thr Leu Ile 
    1265                 1270                 1275             


Thr Ser  Arg Thr Lys Leu Ser  Ser Ile Thr Ser Glu  Ala Thr Gly 
    1280                 1285                 1290             


Asn Glu  Ser His Pro Tyr Leu  Asn Lys Asp Gly Ser  Gln Lys Gly 
    1295                 1300                 1305             


Ile His  Ala Gly Gln Met Gly  Glu Asn Asp Ser Phe  Pro Ala Trp 
    1310                 1315                 1320             


Ala Ile  Val Ile Val Val Leu  Val Ala Val Ile Leu  Leu Leu Val 
    1325                 1330                 1335             


Phe Leu  Gly Leu Ile Phe Leu  Val Ser Tyr Met Met  Arg Thr Arg 
    1340                 1345                 1350             


Arg Thr  Leu Thr Gln Asn Thr  Gln Tyr Asn Asp Ala  Glu Asp Glu 
    1355                 1360                 1365             


Gly Gly  Pro Asn Ser Tyr Pro  Val Tyr Leu Met Glu  Gln Gln Asn 
    1370                 1375                 1380             


Leu Gly  Met Gly Gln Ile Pro  Ser Pro Arg 
    1385                 1390             


<210>  3226
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPEP1__Homo_sapiens__NP_001121613

<400>  3226

Met Trp Ser Gly Trp Trp Leu Trp Pro Leu Val Ala Val Cys Thr Ala 
1               5                   10                  15      


Asp Phe Phe Arg Asp Glu Ala Glu Arg Ile Met Arg Asp Ser Pro Val 
            20                  25                  30          


Ile Asp Gly His Asn Asp Leu Pro Trp Gln Leu Leu Asp Met Phe Asn 
        35                  40                  45              


Asn Arg Leu Gln Asp Glu Arg Ala Asn Leu Thr Thr Leu Ala Gly Thr 
    50                  55                  60                  


His Thr Asn Ile Pro Lys Leu Arg Ala Gly Phe Val Gly Gly Gln Phe 
65                  70                  75                  80  


Trp Ser Val Tyr Thr Pro Cys Asp Thr Gln Asn Lys Asp Ala Val Arg 
                85                  90                  95      


Arg Thr Leu Glu Gln Met Asp Val Val His Arg Met Cys Arg Met Tyr 
            100                 105                 110         


Pro Glu Thr Phe Leu Tyr Val Thr Ser Ser Ala Gly Ile Arg Gln Ala 
        115                 120                 125             


Phe Arg Glu Gly Lys Val Ala Ser Leu Ile Gly Val Glu Gly Gly His 
    130                 135                 140                 


Ser Ile Asp Ser Ser Leu Gly Val Leu Arg Ala Leu Tyr Gln Leu Gly 
145                 150                 155                 160 


Met Arg Tyr Leu Thr Leu Thr His Ser Cys Asn Thr Pro Trp Ala Asp 
                165                 170                 175     


Asn Trp Leu Val Asp Thr Gly Asp Ser Glu Pro Gln Ser Gln Gly Leu 
            180                 185                 190         


Ser Pro Phe Gly Gln Arg Val Val Lys Glu Leu Asn Arg Leu Gly Val 
        195                 200                 205             


Leu Ile Asp Leu Ala His Val Ser Val Ala Thr Met Lys Ala Thr Leu 
    210                 215                 220                 


Gln Leu Ser Arg Ala Pro Val Ile Phe Ser His Ser Ser Ala Tyr Ser 
225                 230                 235                 240 


Val Cys Ala Ser Arg Arg Asn Val Pro Asp Asp Val Leu Arg Leu Val 
                245                 250                 255     


Lys Gln Thr Asp Ser Leu Val Met Val Asn Phe Tyr Asn Asn Tyr Ile 
            260                 265                 270         


Ser Cys Thr Asn Lys Ala Asn Leu Ser Gln Val Ala Asp His Leu Asp 
        275                 280                 285             


His Ile Lys Glu Val Ala Gly Ala Arg Ala Val Gly Phe Gly Gly Asp 
    290                 295                 300                 


Phe Asp Gly Val Pro Arg Val Pro Glu Gly Leu Glu Asp Val Ser Lys 
305                 310                 315                 320 


Tyr Pro Asp Leu Ile Ala Glu Leu Leu Arg Arg Asn Trp Thr Glu Ala 
                325                 330                 335     


Glu Val Lys Gly Ala Leu Ala Asp Asn Leu Leu Arg Val Phe Glu Ala 
            340                 345                 350         


Val Glu Gln Ala Ser Asn Leu Thr Gln Ala Pro Glu Glu Glu Pro Ile 
        355                 360                 365             


Pro Leu Asp Gln Leu Gly Gly Ser Cys Arg Thr His Tyr Gly Tyr Ser 
    370                 375                 380                 


Ser Gly Ala Ser Ser Leu His Arg His Trp Gly Leu Leu Leu Ala Ser 
385                 390                 395                 400 


Leu Ala Pro Leu Val Leu Cys Leu Ser Leu Leu 
                405                 410     


<210>  3227
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPEP2__Homo_sapiens__NP_071750

<400>  3227

Met Gln Pro Ser Gly Leu Glu Gly Pro Gly Thr Phe Gly Arg Trp Pro 
1               5                   10                  15      


Leu Leu Ser Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Val Thr Cys 
            20                  25                  30          


Ala Tyr Thr Thr Pro Gly Pro Pro Arg Ala Leu Thr Thr Leu Gly Ala 
        35                  40                  45              


Pro Arg Ala His Thr Met Pro Gly Thr Tyr Ala Pro Ser Thr Thr Leu 
    50                  55                  60                  


Ser Ser Pro Ser Thr Gln Gly Leu Gln Glu Gln Ala Arg Ala Leu Met 
65                  70                  75                  80  


Arg Asp Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Leu Val Leu 
                85                  90                  95      


Arg Gln Val Tyr Gln Lys Gly Leu Gln Asp Val Asn Leu Arg Asn Phe 
            100                 105                 110         


Ser Tyr Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val Gly 
        115                 120                 125             


Ala Gln Phe Trp Ser Ala Tyr Val Pro Cys Gln Thr Gln Asp Arg Asp 
    130                 135                 140                 


Ala Leu Arg Leu Thr Leu Glu Gln Ile Asp Leu Ile Arg Arg Met Cys 
145                 150                 155                 160 


Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Lys Ala Leu Asn 
                165                 170                 175     


Asp Thr Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His Ser 
            180                 185                 190         


Leu Asp Asn Ser Leu Ser Ile Leu Arg Thr Phe Tyr Met Leu Gly Val 
        195                 200                 205             


Arg Tyr Leu Thr Leu Thr His Thr Cys Asn Thr Pro Trp Ala Glu Ser 
    210                 215                 220                 


Ser Ala Lys Gly Val His Ser Phe Tyr Asn Asn Ile Ser Gly Leu Thr 
225                 230                 235                 240 


Asp Phe Gly Glu Lys Val Val Ala Glu Met Asn Arg Leu Gly Met Met 
                245                 250                 255     


Val Asp Leu Ser His Val Ser Asp Ala Val Ala Arg Arg Ala Leu Glu 
            260                 265                 270         


Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Gly Val 
        275                 280                 285             


Cys Asn Ser Ala Arg Asn Val Pro Asp Asp Ile Leu Gln Leu Leu Lys 
    290                 295                 300                 


Lys Asn Gly Gly Val Val Met Val Ser Leu Ser Met Gly Val Ile Gln 
305                 310                 315                 320 


Cys Asn Pro Ser Ala Asn Val Ser Thr Val Ala Asp His Phe Asp His 
                325                 330                 335     


Ile Lys Ala Val Ile Gly Ser Lys Phe Ile Gly Ile Gly Gly Asp Tyr 
            340                 345                 350         


Asp Gly Ala Gly Lys Phe Pro Gln Gly Leu Glu Asp Val Ser Thr Tyr 
        355                 360                 365             


Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Gly Trp Ser Glu Glu Glu 
    370                 375                 380                 


Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln Val 
385                 390                 395                 400 


Glu Lys Val Gln Glu Glu Asn Lys Trp Gln Ser Pro Leu Glu Asp Lys 
                405                 410                 415     


Phe Pro Asp Glu Gln Leu Ser Ser Ser Cys His Ser Asp Leu Ser Arg 
            420                 425                 430         


Leu Arg Gln Arg Gln Ser Leu Thr Ser Gly Gln Glu Leu Thr Glu Ile 
        435                 440                 445             


Pro Ile His Trp Thr Ala Lys Leu Pro Ala Lys Trp Ser Val Ser Glu 
    450                 455                 460                 


Ser Ser Pro His Met Ala Pro Val Leu Ala Val Val Ala Thr Phe Pro 
465                 470                 475                 480 


Val Leu Ile Leu Trp Leu 
                485     


<210>  3228
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPEP3__Homo_sapiens__NP_071752

<400>  3228

Met Ile Arg Thr Pro Leu Ser Ala Ser Ala His Arg Leu Leu Leu Pro 
1               5                   10                  15      


Gly Ser Arg Gly Arg Pro Pro Arg Asn Met Gln Pro Thr Gly Arg Glu 
            20                  25                  30          


Gly Ser Arg Ala Leu Ser Arg Arg Tyr Leu Arg Arg Leu Leu Leu Leu 
        35                  40                  45              


Leu Leu Leu Leu Leu Leu Arg Gln Pro Val Thr Arg Ala Glu Thr Thr 
    50                  55                  60                  


Pro Gly Ala Pro Arg Ala Leu Ser Thr Leu Gly Ser Pro Ser Leu Phe 
65                  70                  75                  80  


Thr Thr Pro Gly Val Pro Ser Ala Leu Thr Thr Pro Gly Leu Thr Thr 
                85                  90                  95      


Pro Gly Thr Pro Lys Thr Leu Asp Leu Arg Gly Arg Ala Gln Ala Leu 
            100                 105                 110         


Met Arg Ser Phe Pro Leu Val Asp Gly His Asn Asp Leu Pro Gln Val 
        115                 120                 125             


Leu Arg Gln Arg Tyr Lys Asn Val Leu Gln Asp Val Asn Leu Arg Asn 
    130                 135                 140                 


Phe Ser His Gly Gln Thr Ser Leu Asp Arg Leu Arg Asp Gly Leu Val 
145                 150                 155                 160 


Gly Ala Gln Phe Trp Ser Ala Ser Val Ser Cys Gln Ser Gln Asp Gln 
                165                 170                 175     


Thr Ala Val Arg Leu Ala Leu Glu Gln Ile Asp Leu Ile His Arg Met 
            180                 185                 190         


Cys Ala Ser Tyr Ser Glu Leu Glu Leu Val Thr Ser Ala Glu Gly Leu 
        195                 200                 205             


Asn Ser Ser Gln Lys Leu Ala Cys Leu Ile Gly Val Glu Gly Gly His 
    210                 215                 220                 


Ser Leu Asp Ser Ser Leu Ser Val Leu Arg Ser Phe Tyr Val Leu Gly 
225                 230                 235                 240 


Val Arg Tyr Leu Thr Leu Thr Phe Thr Cys Ser Thr Pro Trp Ala Glu 
                245                 250                 255     


Ser Ser Thr Lys Phe Arg His His Met Tyr Thr Asn Val Ser Gly Leu 
            260                 265                 270         


Thr Ser Phe Gly Glu Lys Val Val Glu Glu Leu Asn Arg Leu Gly Met 
        275                 280                 285             


Met Ile Asp Leu Ser Tyr Ala Ser Asp Thr Leu Ile Arg Arg Val Leu 
    290                 295                 300                 


Glu Val Ser Gln Ala Pro Val Ile Phe Ser His Ser Ala Ala Arg Ala 
305                 310                 315                 320 


Val Cys Asp Asn Leu Leu Asn Val Pro Asp Asp Ile Leu Gln Leu Leu 
                325                 330                 335     


Lys Lys Asn Gly Gly Ile Val Met Val Thr Leu Ser Met Gly Val Leu 
            340                 345                 350         


Gln Cys Asn Leu Leu Ala Asn Val Ser Thr Val Ala Asp His Phe Asp 
        355                 360                 365             


His Ile Arg Ala Val Ile Gly Ser Glu Phe Ile Gly Ile Gly Gly Asn 
    370                 375                 380                 


Tyr Asp Gly Thr Gly Arg Phe Pro Gln Gly Leu Glu Asp Val Ser Thr 
385                 390                 395                 400 


Tyr Pro Val Leu Ile Glu Glu Leu Leu Ser Arg Ser Trp Ser Glu Glu 
                405                 410                 415     


Glu Leu Gln Gly Val Leu Arg Gly Asn Leu Leu Arg Val Phe Arg Gln 
            420                 425                 430         


Val Glu Lys Val Arg Glu Glu Ser Arg Ala Gln Ser Pro Val Glu Ala 
        435                 440                 445             


Glu Phe Pro Tyr Gly Gln Leu Ser Thr Ser Cys His Ser His Leu Val 
    450                 455                 460                 


Pro Gln Asn Gly His Gln Ala Thr His Leu Glu Val Thr Lys Gln Pro 
465                 470                 475                 480 


Thr Asn Arg Val Pro Trp Arg Ser Ser Asn Ala Ser Pro Tyr Leu Val 
                485                 490                 495     


Pro Gly Leu Val Ala Ala Ala Thr Ile Pro Thr Phe Thr Gln Trp Leu 
            500                 505                 510         


Cys 
    


<210>  3229
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPF1__Homo_sapiens__NP_001128627

<400>  3229

Met Gly Gly Leu Ser Ala Arg Pro Thr Ala Gly Arg Thr Asp Pro Ala 
1               5                   10                  15      


Gly Thr Cys Trp Gly Gln Asp Pro Gly Ser Lys Met Ala Thr Val Ile 
            20                  25                  30          


Pro Gly Pro Leu Ser Leu Gly Glu Asp Phe Tyr Arg Glu Ala Ile Glu 
        35                  40                  45              


His Cys Arg Ser Tyr Asn Ala Arg Leu Cys Ala Glu Arg Ser Leu Arg 
    50                  55                  60                  


Leu Pro Phe Leu Asp Ser Gln Thr Gly Val Ala Gln Asn Asn Cys Tyr 
65                  70                  75                  80  


Ile Trp Met Glu Lys Thr His Arg Gly Pro Gly Leu Ala Pro Gly Gln 
                85                  90                  95      


Ile Tyr Thr Tyr Pro Ala Arg Cys Trp Arg Lys Lys Arg Arg Leu Asn 
            100                 105                 110         


Ile Leu Glu Asp Pro Arg Leu Arg Pro Cys Glu Tyr Lys Ile Asp Cys 
        115                 120                 125             


Glu Ala Pro Leu Lys Lys Glu Gly Gly Leu Pro Glu Gly Pro Val Leu 
    130                 135                 140                 


Glu Ala Leu Leu Cys Ala Glu Thr Gly Glu Lys Lys Ile Glu Leu Lys 
145                 150                 155                 160 


Glu Glu Glu Thr Ile Met Asp Cys Gln Lys Gln Gln Leu Leu Glu Phe 
                165                 170                 175     


Pro His Asp Leu Glu Val Glu Asp Leu Glu Asp Asp Ile Pro Arg Arg 
            180                 185                 190         


Lys Asn Arg Ala Lys Gly Lys Ala Tyr Gly Ile Gly Gly Leu Arg Lys 
        195                 200                 205             


Arg Gln Asp Thr Ala Ser Leu Glu Asp Arg Asp Lys Pro Tyr Val Cys 
    210                 215                 220                 


Asp Ile Cys Gly Lys Arg Tyr Lys Asn Arg Pro Gly Leu Ser Tyr His 
225                 230                 235                 240 


Tyr Thr His Thr His Leu Ala Glu Glu Glu Gly Glu Glu Asn Ala Glu 
                245                 250                 255     


Arg His Ala Leu Pro Phe His Arg Lys Asn Asn His Lys Gln Phe Tyr 
            260                 265                 270         


Lys Glu Leu Ala Trp Val Pro Glu Ala Gln Arg Lys His Thr Ala Lys 
        275                 280                 285             


Lys Ala Pro Asp Gly Thr Val Ile Pro Asn Gly Tyr Cys Asp Phe Cys 
    290                 295                 300                 


Leu Gly Gly Ser Lys Lys Thr Gly Cys Pro Glu Asp Leu Ile Ser Cys 
305                 310                 315                 320 


Ala Asp Cys Gly Arg Ser Gly His Pro Ser Cys Leu Gln Phe Thr Val 
                325                 330                 335     


Asn Met Thr Ala Ala Val Arg Thr Tyr Arg Trp Gln Cys Ile Glu Cys 
            340                 345                 350         


Lys Ser Cys Ser Leu Cys Gly Thr Ser Glu Asn Asp Asp Gln Leu Leu 
        355                 360                 365             


Phe Cys Asp Asp Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Ser Pro 
    370                 375                 380                 


Pro Met Ala Glu Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Leu 
385                 390                 395                 400 


Arg His Leu Lys Glu Lys Ala Ser Ala Tyr Ile Thr Leu Thr 
                405                 410                 


<210>  3230
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPF3__Homo_sapiens__NP_001267471

<400>  3230

Met Ala Thr Val Ile His Asn Pro Leu Lys Ala Leu Gly Asp Gln Phe 
1               5                   10                  15      


Tyr Lys Glu Ala Ile Glu His Cys Arg Ser Tyr Asn Ser Arg Leu Cys 
            20                  25                  30          


Ala Glu Arg Ser Val Arg Leu Pro Phe Leu Asp Ser Gln Thr Gly Val 
        35                  40                  45              


Ala Gln Asn Asn Cys Tyr Ile Trp Met Glu Lys Arg His Arg Gly Pro 
    50                  55                  60                  


Gly Leu Ala Pro Gly Gln Leu Tyr Thr Tyr Pro Ala Arg Cys Trp Arg 
65                  70                  75                  80  


Lys Lys Arg Arg Leu His Pro Pro Glu Asp Pro Lys Leu Arg Leu Leu 
                85                  90                  95      


Glu Ile Lys Pro Glu Val Glu Leu Pro Leu Lys Lys Asp Gly Phe Thr 
            100                 105                 110         


Ser Glu Ser Thr Thr Leu Glu Ala Leu Leu Arg Gly Glu Gly Val Glu 
        115                 120                 125             


Lys Lys Val Asp Ala Arg Glu Glu Glu Ser Ile Gln Glu Ile Gln Arg 
    130                 135                 140                 


Val Leu Glu Asn Asp Glu Asn Val Glu Glu Gly Asn Glu Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Glu Asp Ile Pro Lys Arg Lys Asn Arg Thr Arg Gly Arg Ala 
                165                 170                 175     


Arg Gly Ser Ala Gly Gly Arg Arg Arg His Asp Ala Ala Ser Gln Glu 
            180                 185                 190         


Asp His Asp Lys Pro Tyr Val Cys Asp Ile Cys Gly Lys Arg Tyr Lys 
        195                 200                 205             


Asn Arg Pro Gly Leu Ser Tyr His Tyr Ala His Thr His Leu Ala Ser 
    210                 215                 220                 


Glu Glu Gly Asp Glu Ala Gln Asp Gln Glu Thr Arg Ser Pro Pro Asn 
225                 230                 235                 240 


His Arg Asn Glu Asn His Arg Pro Gln Lys Gly Pro Asp Gly Thr Val 
                245                 250                 255     


Ile Pro Asn Asn Tyr Cys Asp Phe Cys Leu Gly Gly Ser Asn Met Asn 
            260                 265                 270         


Lys Lys Ser Gly Arg Pro Glu Glu Leu Val Ser Cys Ala Asp Cys Gly 
        275                 280                 285             


Arg Ser Gly His Pro Thr Cys Leu Gln Phe Thr Leu Asn Met Thr Glu 
    290                 295                 300                 


Ala Val Lys Thr Tyr Lys Trp Gln Cys Ile Glu Cys Lys Ser Cys Ile 
305                 310                 315                 320 


Leu Cys Gly Thr Ser Glu Asn Asp Asp Gln Leu Leu Phe Cys Asp Asp 
                325                 330                 335     


Cys Asp Arg Gly Tyr His Met Tyr Cys Leu Asn Pro Pro Val Ala Glu 
            340                 345                 350         


Pro Pro Glu Gly Ser Trp Ser Cys His Leu Cys Trp Glu Leu Leu Lys 
        355                 360                 365             


Glu Lys Ala Ser Ala Phe Gly Cys Gln Ala 
    370                 375             


<210>  3231
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPH1__Homo_sapiens__NP_001374

<400>  3231

Met Arg Arg Gln Val Met Ala Ala Leu Val Val Ser Gly Ala Ala Glu 
1               5                   10                  15      


Gln Gly Gly Arg Asp Gly Pro Gly Arg Gly Arg Ala Pro Arg Gly Arg 
            20                  25                  30          


Val Ala Asn Gln Ile Pro Pro Glu Ile Leu Lys Asn Pro Gln Leu Gln 
        35                  40                  45              


Ala Ala Ile Arg Val Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys 
    50                  55                  60                  


Thr Ile Trp Arg Ile Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Met Pro Glu Gly Leu Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu 
                85                  90                  95      


Glu Arg Phe Thr Glu Ala Glu Val Met Val Met Gly Asp Val Thr Tyr 
            100                 105                 110         


Gly Ala Cys Cys Val Asp Asp Phe Thr Ala Arg Ala Leu Gly Ala Asp 
        115                 120                 125             


Phe Leu Val His Tyr Gly His Ser Cys Leu Ile Pro Met Asp Thr Ser 
    130                 135                 140                 


Ala Gln Asp Phe Arg Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp 
145                 150                 155                 160 


Thr Thr His Leu Leu Asp Ser Leu Arg Leu Thr Phe Pro Pro Ala Thr 
                165                 170                 175     


Ala Leu Ala Leu Val Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala 
            180                 185                 190         


Ala Ala Gln Glu Leu Lys Ala Glu Tyr Arg Val Ser Val Pro Gln Cys 
        195                 200                 205             


Lys Pro Leu Ser Pro Gly Glu Ile Leu Gly Cys Thr Ser Pro Arg Leu 
    210                 215                 220                 


Ser Lys Glu Val Glu Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His 
225                 230                 235                 240 


Leu Glu Ser Val Met Ile Ala Asn Pro Asn Val Pro Ala Tyr Arg Tyr 
                245                 250                 255     


Asp Pro Tyr Ser Lys Val Leu Ser Arg Glu His Tyr Asp His Gln Arg 
            260                 265                 270         


Met Gln Ala Ala Arg Gln Glu Ala Ile Ala Thr Ala Arg Ser Ala Lys 
        275                 280                 285             


Ser Trp Gly Leu Ile Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys 
    290                 295                 300                 


Ile Leu Glu His Leu Glu Ser Arg Leu Arg Ala Leu Gly Leu Ser Phe 
305                 310                 315                 320 


Val Arg Leu Leu Leu Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu 
                325                 330                 335     


Pro Glu Val Asp Val Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile 
            340                 345                 350         


Asp Trp Gly Thr Ala Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala 
        355                 360                 365             


Ala Val Ala Leu Arg Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp 
    370                 375                 380                 


Phe Tyr Ala Gly Ser Ser Leu Gly Pro Trp Thr Val Asn His Gly Gln 
385                 390                 395                 400 


Asp Arg Arg Pro His Ala Pro Gly Arg Pro Ala Arg Gly Lys Val Gln 
                405                 410                 415     


Glu Gly Ser Ala Arg Pro Pro Ser Ala Val Ala Cys Glu Asp Cys Ser 
            420                 425                 430         


Cys Arg Asp Glu Lys Val Ala Pro Leu Ala Pro 
        435                 440             


<210>  3232
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPH3__Homo_sapiens__NP_001040899

<400>  3232

Met Ala Val Phe His Asp Glu Val Glu Ile Glu Asp Phe Gln Tyr Asp 
1               5                   10                  15      


Glu Asp Ser Glu Thr Tyr Phe Tyr Pro Cys Pro Cys Gly Asp Asn Phe 
            20                  25                  30          


Ser Ile Thr Lys Asp Gln Phe Val Cys Gly Glu Thr Val Pro Ala Pro 
        35                  40                  45              


Ser Ala Asn Lys Glu Leu Val Lys Cys 
    50                  55          


<210>  3233
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPH6__Homo_sapiens__NP_001135444

<400>  3233

Met Arg Val Ala Ala Leu Ile Ser Gly Gly Lys Asp Ser Cys Tyr Asn 
1               5                   10                  15      


Met Met Gln Cys Ile Ala Ala Gly His Gln Ile Val Ala Leu Ala Asn 
            20                  25                  30          


Leu Arg Pro Ala Glu Asn Gln Val Gly Ser Asp Glu Leu Asp Ser Tyr 
        35                  40                  45              


Met Tyr Gln Thr Val Gly His His Ala Ile Asp Leu Tyr Ala Glu Ala 
    50                  55                  60                  


Met Ala Leu Pro Leu Tyr Arg Arg Thr Ile Arg Gly Arg Ser Leu Asp 
65                  70                  75                  80  


Thr Arg Gln Val Tyr Thr Lys Cys Glu Gly Asp Glu Val Glu Asp Leu 
                85                  90                  95      


Tyr Glu Leu Leu Lys Leu Val Lys Gly Ile Thr Arg Met Thr Leu Leu 
            100                 105                 110         


Ala Glu Tyr Asp Ala Leu Asn Leu Gln Asp Phe His Met His Leu Lys 
        115                 120                 125             


Val Gly Ser Gln Ala Ile Val Tyr Arg Thr Pro Asn Glu Leu Cys Thr 
    130                 135                 140                 


His Ser Lys Phe Asp Lys His Thr Phe Pro Pro Phe Ile Ser Glu Ile 
145                 150                 155                 160 


Ala Lys Cys Glu Val 
                165 


<210>  3234
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPH7__Homo_sapiens__NP_620133

<400>  3234

Met Met Gly Cys Phe Ala Leu Gln Thr Val Asp Thr Glu Leu Thr Ala 
1               5                   10                  15      


Asp Ser Val Glu Trp Cys Pro Leu Gln Gly Cys Arg His Leu Leu Ala 
            20                  25                  30          


Cys Gly Thr Tyr Gln Leu Arg Arg Pro Glu Asp Arg Pro Ala Gly Pro 
        35                  40                  45              


Gln Asn Lys Gly Gly Met Glu Val Lys Glu Pro Gln Val Arg Leu Gly 
    50                  55                  60                  


Arg Leu Phe Leu Tyr Ser Phe Asn Asp Asn Asn Ser Ile His Pro Leu 
65                  70                  75                  80  


Val Glu Val Gln Arg Lys Asp Thr Ser Ala Ile Leu Asp Met Lys Trp 
                85                  90                  95      


Cys His Ile Pro Val Ala Gly His Ala Leu Leu Gly Leu Ala Asp Ala 
            100                 105                 110         


Ser Gly Ser Ile Gln Leu Leu Arg Leu Val Glu Ser Glu Lys Ser His 
        115                 120                 125             


Val Leu Glu Pro Leu Ser Ser Leu Ala Leu Glu Glu Gln Cys Leu Ala 
    130                 135                 140                 


Leu Ser Leu Asp Trp Ser Thr Gly Lys Thr Gly Arg Ala Gly Asp Gln 
145                 150                 155                 160 


Pro Leu Lys Ile Ile Ser Ser Asp Ser Thr Gly Gln Leu His Leu Leu 
                165                 170                 175     


Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
            180                 185                 190         


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
        195                 200                 205             


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
    210                 215                 220                 


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Arg His Thr Met 
225                 230                 235                 240 


Gly Val Cys Ser Ile Gln Ser Ser Pro His Arg Glu His Ile Leu Ala 
                245                 250                 255     


Thr Gly Ser Tyr Asp Glu His Ile Leu Leu Trp Asp Thr Arg Asn Met 
            260                 265                 270         


Lys Gln Pro Leu Ala Asp Thr Pro Val Gln Gly Gly Val Trp Arg Ile 
        275                 280                 285             


Lys Trp His Pro Phe His His His Leu Leu Leu Ala Ala Cys Met His 
    290                 295                 300                 


Ser Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala Met Glu Glu Arg Gln 
305                 310                 315                 320 


Glu Ala Thr Val Leu Thr Ser His Thr Leu Pro Asp Ser Leu Val Tyr 
                325                 330                 335     


Gly Ala Asp Trp Ser Trp Leu Leu Phe Arg Ser Leu Gln Arg Ala Pro 
            340                 345                 350         


Ser Trp Ser Phe Pro Ser Asn Leu Gly Thr Lys Thr Ala Asp Leu Lys 
        355                 360                 365             


Gly Ala Ser Glu Leu Pro Thr Pro Cys His Glu Cys Arg Glu Asp Asn 
    370                 375                 380                 


Asp Gly Glu Gly His Ala Arg Pro Gln Ser Gly Met Lys Pro Leu Thr 
385                 390                 395                 400 


Glu Gly Met Arg Lys Asn Gly Thr Trp Leu Gln Ala Thr Ala Ala Thr 
                405                 410                 415     


Thr Arg Asp Cys Gly Val Asn Pro Glu Glu Ala Asp Ser Ala Phe Ser 
            420                 425                 430         


Leu Leu Ala Thr Cys Ser Phe Tyr Asp His Ala Leu His Leu Trp Glu 
        435                 440                 445             


Trp Glu Gly Asn 
    450         


<210>  3235
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPM1__Homo_sapiens__NP_003850

<400>  3235

Met Ala Ser Leu Glu Val Ser Arg Ser Pro Arg Arg Ser Arg Arg Glu 
1               5                   10                  15      


Leu Glu Val Arg Ser Pro Arg Gln Asn Lys Tyr Ser Val Leu Leu Pro 
            20                  25                  30          


Thr Tyr Asn Glu Arg Glu Asn Leu Pro Leu Ile Val Trp Leu Leu Val 
        35                  40                  45              


Lys Ser Phe Ser Glu Ser Gly Ile Asn Tyr Glu Ile Ile Ile Ile Asp 
    50                  55                  60                  


Asp Gly Ser Pro Asp Gly Thr Arg Asp Val Ala Glu Gln Leu Glu Lys 
65                  70                  75                  80  


Ile Tyr Gly Ser Asp Arg Ile Leu Leu Arg Pro Arg Glu Lys Lys Leu 
                85                  90                  95      


Gly Leu Gly Thr Ala Tyr Ile His Gly Met Lys His Ala Thr Gly Asn 
            100                 105                 110         


Tyr Ile Ile Ile Met Asp Ala Asp Leu Ser His His Pro Lys Phe Ile 
        115                 120                 125             


Pro Glu Phe Ile Arg Lys Gln Lys Glu Gly Asn Phe Asp Ile Val Ser 
    130                 135                 140                 


Gly Thr Arg Tyr Lys Gly Asn Gly Gly Val Tyr Gly Trp Asp Leu Lys 
145                 150                 155                 160 


Arg Lys Ile Ile Ser Arg Gly Ala Asn Phe Leu Thr Gln Ile Leu Leu 
                165                 170                 175     


Arg Pro Gly Ala Ser Asp Leu Thr Gly Ser Phe Arg Leu Tyr Arg Lys 
            180                 185                 190         


Glu Val Leu Glu Lys Leu Ile Glu Lys Cys Val Ser Lys Gly Tyr Val 
        195                 200                 205             


Phe Gln Met Glu Met Ile Val Arg Ala Arg Gln Leu Asn Tyr Thr Ile 
    210                 215                 220                 


Gly Glu Val Pro Ile Ser Phe Val Asp Arg Val Tyr Gly Glu Ser Lys 
225                 230                 235                 240 


Leu Gly Gly Asn Glu Ile Val Ser Phe Leu Lys Gly Leu Leu Thr Leu 
                245                 250                 255     


Phe Ala Thr Thr 
            260 


<210>  3236
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPM2__Homo_sapiens__NP_003854

<400>  3236

Met Ala Thr Gly Thr Asp Gln Val Val Gly Leu Gly Leu Val Ala Val 
1               5                   10                  15      


Ser Leu Ile Ile Phe Thr Tyr Tyr Thr Ala Trp Val Ile Leu Leu Pro 
            20                  25                  30          


Phe Ile Asp Ser Gln His Val Ile His Lys Tyr Phe Leu Pro Arg Ala 
        35                  40                  45              


Tyr Ala Val Ala Ile Pro Leu Ala Ala Gly Leu Leu Leu Leu Leu Phe 
    50                  55                  60                  


Val Gly Leu Phe Ile Ser Tyr Val Met Leu Lys Thr Lys Arg Val Thr 
65                  70                  75                  80  


Lys Lys Ala Gln 
                


<210>  3237
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPM3__Homo_sapiens__NP_061846

<400>  3237

Met Leu Ser Val Gly Gly Leu Arg Leu Ser Leu Val Arg Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Arg Gly Ala Leu Leu Pro Ser Leu Ala Val Thr Met Thr 
            20                  25                  30          


Lys Leu Ala Gln Trp Leu Trp Gly Leu Ala Ile Leu Gly Ser Thr Trp 
        35                  40                  45              


Val Ala Leu Thr Thr Gly Ala Leu Gly Leu Glu Leu Pro Leu Ser Cys 
    50                  55                  60                  


Gln Glu Val Leu Trp Pro Leu Pro Ala Tyr Leu Leu Val Ser Ala Gly 
65                  70                  75                  80  


Cys Tyr Ala Leu Gly Thr Val Gly Tyr Arg Val Ala Thr Phe His Asp 
                85                  90                  95      


Cys Glu Asp Ala Ala Arg Glu Leu Gln Ser Gln Ile Gln Glu Ala Arg 
            100                 105                 110         


Ala Asp Leu Ala Arg Arg Gly Leu Arg Phe 
        115                 120         


<210>  3238
<211>  800
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPP10__Homo_sapiens__NP_001171505

<400>  3238

Met Thr Ala Ala Lys Gln Glu Pro Gln Pro Thr Pro Gly Ala Arg Ala 
1               5                   10                  15      


Ser Gln Ala Gln Pro Ala Asp Gln Glu Leu Gly Ser Asn Ser Pro Pro 
            20                  25                  30          


Gln Arg Asn Trp Lys Gly Ile Ala Ile Ala Leu Leu Val Ile Leu Val 
        35                  40                  45              


Val Cys Ser Leu Ile Thr Met Ser Val Ile Leu Leu Thr Pro Asp Glu 
    50                  55                  60                  


Leu Thr Asn Ser Ser Glu Thr Arg Leu Ser Leu Glu Asp Leu Phe Arg 
65                  70                  75                  80  


Lys Asp Phe Val Leu His Asp Pro Glu Ala Arg Trp Ile Asn Asp Thr 
                85                  90                  95      


Asp Val Val Tyr Lys Ser Glu Asn Gly His Val Ile Lys Leu Asn Ile 
            100                 105                 110         


Glu Thr Asn Ala Thr Thr Leu Leu Leu Glu Asn Thr Thr Phe Val Thr 
        115                 120                 125             


Phe Lys Ala Ser Arg His Ser Val Ser Pro Asp Leu Lys Tyr Val Leu 
    130                 135                 140                 


Leu Ala Tyr Asp Val Lys Gln Ile Phe His Tyr Ser Tyr Thr Ala Ser 
145                 150                 155                 160 


Tyr Val Ile Tyr Asn Ile His Thr Arg Glu Val Trp Glu Leu Asn Pro 
                165                 170                 175     


Pro Glu Val Glu Asp Ser Val Leu Gln Tyr Ala Ala Trp Gly Val Gln 
            180                 185                 190         


Gly Gln Gln Leu Ile Tyr Ile Phe Glu Asn Asn Ile Tyr Tyr Gln Pro 
        195                 200                 205             


Asp Ile Lys Ser Ser Ser Leu Arg Leu Thr Ser Ser Gly Lys Glu Glu 
    210                 215                 220                 


Ile Ile Phe Asn Gly Ile Ala Asp Trp Leu Tyr Glu Glu Glu Leu Leu 
225                 230                 235                 240 


His Ser His Ile Ala His Trp Trp Ser Pro Asp Gly Glu Arg Leu Ala 
                245                 250                 255     


Phe Leu Met Ile Asn Asp Ser Leu Val Pro Thr Met Val Ile Pro Arg 
            260                 265                 270         


Phe Thr Gly Ala Leu Tyr Pro Lys Gly Lys Gln Tyr Pro Tyr Pro Lys 
        275                 280                 285             


Ala Gly Gln Val Asn Pro Thr Ile Lys Leu Tyr Val Val Asn Leu Tyr 
    290                 295                 300                 


Gly Pro Thr His Thr Leu Glu Leu Met Pro Pro Asp Ser Phe Lys Ser 
305                 310                 315                 320 


Arg Glu Tyr Tyr Ile Thr Met Val Lys Trp Val Ser Asn Thr Lys Thr 
                325                 330                 335     


Val Val Arg Trp Leu Asn Arg Ala Gln Asn Ile Ser Ile Leu Thr Val 
            340                 345                 350         


Cys Glu Thr Thr Thr Gly Ala Cys Ser Lys Lys Tyr Glu Met Thr Ser 
        355                 360                 365             


Asp Thr Trp Leu Ser Gln Gln Asn Glu Glu Pro Val Phe Ser Arg Asp 
    370                 375                 380                 


Gly Ser Lys Phe Phe Met Thr Val Pro Val Lys Gln Gly Gly Arg Gly 
385                 390                 395                 400 


Glu Phe His His Ile Ala Met Phe Leu Ile Gln Ser Lys Ser Glu Gln 
                405                 410                 415     


Ile Thr Val Arg His Leu Thr Ser Gly Asn Trp Glu Val Ile Lys Ile 
            420                 425                 430         


Leu Ala Tyr Asp Glu Thr Thr Gln Lys Ile Tyr Phe Leu Ser Thr Glu 
        435                 440                 445             


Ser Ser Pro Arg Gly Arg Gln Leu Tyr Ser Ala Ser Thr Glu Gly Leu 
    450                 455                 460                 


Leu Asn Arg Gln Cys Ile Ser Cys Asn Phe Met Lys Glu Gln Cys Thr 
465                 470                 475                 480 


Tyr Phe Asp Ala Ser Phe Ser Pro Met Asn Gln His Phe Leu Leu Phe 
                485                 490                 495     


Cys Glu Gly Pro Arg Val Pro Val Val Ser Leu His Ser Thr Asp Asn 
            500                 505                 510         


Pro Ala Lys Tyr Phe Ile Leu Glu Ser Asn Ser Met Leu Lys Glu Ala 
        515                 520                 525             


Ile Leu Lys Lys Lys Ile Gly Lys Pro Glu Ile Lys Ile Leu His Ile 
    530                 535                 540                 


Asp Asp Tyr Glu Leu Pro Leu Gln Leu Ser Leu Pro Lys Asp Phe Met 
545                 550                 555                 560 


Asp Arg Asn Gln Tyr Ala Leu Leu Leu Ile Met Asp Glu Glu Pro Gly 
                565                 570                 575     


Gly Gln Leu Val Thr Asp Lys Phe His Ile Asp Trp Asp Ser Val Leu 
            580                 585                 590         


Ile Asp Met Asp Asn Val Ile Val Ala Arg Phe Asp Gly Arg Gly Ser 
        595                 600                 605             


Gly Phe Gln Gly Leu Lys Ile Leu Gln Glu Ile His Arg Arg Leu Gly 
    610                 615                 620                 


Ser Val Glu Val Lys Asp Gln Ile Thr Ala Val Lys Phe Leu Leu Lys 
625                 630                 635                 640 


Leu Pro Tyr Ile Asp Ser Lys Arg Leu Ser Ile Phe Gly Lys Gly Tyr 
                645                 650                 655     


Gly Gly Tyr Ile Ala Ser Met Ile Leu Lys Ser Asp Glu Lys Leu Phe 
            660                 665                 670         


Lys Cys Gly Ser Val Val Ala Pro Ile Thr Asp Leu Lys Leu Tyr Ala 
        675                 680                 685             


Ser Ala Phe Ser Glu Arg Tyr Leu Gly Met Pro Ser Lys Glu Glu Ser 
    690                 695                 700                 


Thr Tyr Gln Ala Ala Ser Val Leu His Asn Val His Gly Leu Lys Glu 
705                 710                 715                 720 


Glu Asn Ile Leu Ile Ile His Gly Thr Ala Asp Thr Lys Val His Phe 
                725                 730                 735     


Gln His Ser Ala Glu Leu Ile Lys His Leu Ile Lys Ala Gly Val Asn 
            740                 745                 750         


Tyr Thr Met Gln Val Tyr Pro Asp Glu Gly His Asn Val Ser Glu Lys 
        755                 760                 765             


Ser Lys Tyr His Leu Tyr Ser Thr Ile Leu Lys Phe Phe Ser Asp Cys 
    770                 775                 780                 


Leu Lys Glu Glu Ile Ser Val Leu Pro Gln Glu Pro Glu Glu Asp Glu 
785                 790                 795                 800 


<210>  3239
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPP3__Homo_sapiens__NP_001243599

<400>  3239

Met Ala Asp Thr Gln Tyr Ile Leu Pro Asn Asp Ile Gly Val Ser Ser 
1               5                   10                  15      


Leu Asp Cys Arg Glu Ala Phe Arg Leu Leu Ser Pro Thr Glu Arg Leu 
            20                  25                  30          


Tyr Ala Tyr His Leu Ser Arg Ala Ala Trp Tyr Gly Gly Leu Ala Val 
        35                  40                  45              


Leu Leu Gln Thr Ser Pro Glu Ala Pro Tyr Ile Tyr Ala Leu Leu Ser 
    50                  55                  60                  


Arg Leu Phe Arg Ala Gln Asp Pro Asp Gln Leu Arg Gln His Ala Leu 
65                  70                  75                  80  


Ala Glu Gly Leu Thr Glu Glu Glu Tyr Gln Glu Lys Leu Glu Arg Val 
                85                  90                  95      


Ile Leu Gly Ser Glu Ala Ala Gln Gln His Pro Glu Glu Val Arg Gly 
            100                 105                 110         


Leu Trp Gln Thr Cys Gly Glu Leu Met Phe Ser Leu Glu Pro Arg Leu 
        115                 120                 125             


Arg His Leu Gly Leu Gly Lys Glu Gly Ile Thr Thr Tyr Phe Ser Gly 
    130                 135                 140                 


Asn Cys Thr Met Glu Asp Ala Lys Leu Ala Gln Asp Phe Leu Asp Ser 
145                 150                 155                 160 


Gln Asn Leu Ser Ala Tyr Asn Thr Arg Leu Phe Lys Glu Val Asp Gly 
                165                 170                 175     


Glu Gly Lys Pro Tyr Tyr Glu Val Arg Leu Ala Ser Val Leu Gly Ser 
            180                 185                 190         


Glu Pro Ser Leu Asp Ser Glu Val Thr Ser Lys Leu Lys Ser Tyr Glu 
        195                 200                 205             


Phe Arg Gly Ser Pro Phe Gln Val Thr Arg Gly Asp Tyr Ala Pro Ile 
    210                 215                 220                 


Leu Gln Lys Val Val Glu Gln Leu Glu Lys Ala Lys Ala Tyr Ala Ala 
225                 230                 235                 240 


Asn Ser His Gln Gly Gln Met Leu Ala Gln Tyr Ile Glu Ser Phe Thr 
                245                 250                 255     


Gln Gly Ser Ile Glu Ala His Lys Arg Gly Ser Arg Phe Trp Ile Gln 
            260                 265                 270         


Asp Lys Gly Pro Ile Val Glu Ser Tyr Ile Gly Phe Ile Glu Ser Tyr 
        275                 280                 285             


Arg Asp Pro Phe Gly Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Val 
    290                 295                 300                 


Val Asn Lys Ala Met Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala 
305                 310                 315                 320 


Glu Gln Leu Leu Lys Glu Leu Pro Trp Pro Pro Thr Phe Glu Lys Asp 
                325                 330                 335     


Lys Phe Leu Thr Pro Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala 
            340                 345                 350         


Gly Ser Gly Ile Pro Ala Gly Ile Asn Ile Pro Asn Tyr Asp Asp Leu 
        355                 360                 365             


Arg Gln Thr Glu Gly Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala 
    370                 375                 380                 


Val Ala Tyr Ala Thr Gln Arg Glu Lys Leu Thr Phe Leu Glu Glu Asp 
385                 390                 395                 400 


Asp Lys Asp Leu Tyr Ile Leu Trp Lys Gly Pro Ser Phe Asp Val Gln 
                405                 410                 415     


Val Gly Leu His Glu Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val 
            420                 425                 430         


Gln Asp Glu Lys Gly Ala Phe Asn Phe Asp Gln Glu Thr Val Ile Asn 
        435                 440                 445             


Pro Glu Thr Gly Glu Gln Ile Gln Ser Trp Tyr Arg Ser Gly Glu Thr 
    450                 455                 460                 


Trp Asp Ser Lys Phe Ser Thr Ile Ala Ser Ser Tyr Glu Glu Cys Arg 
465                 470                 475                 480 


Ala Glu Ser Val Gly Leu Tyr Leu Cys Leu His Pro Gln Val Leu Glu 
                485                 490                 495     


Ile Phe Gly Phe Glu Gly Ala Asp Ala Glu Asp Val Ile Tyr Val Asn 
            500                 505                 510         


Trp Leu Asn Met Val Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr 
        515                 520                 525             


Pro Glu Ala Phe Asn Trp Arg Gln Ala His Met Gln Ala Arg Phe Val 
    530                 535                 540                 


Ile Leu Arg Val Leu Leu Glu Ala Gly Glu Gly Leu Val Thr Ile Thr 
545                 550                 555                 560 


Pro Thr Thr Gly Ser Asp Gly Arg Pro Asp Ala Arg Val Arg Leu Asp 
                565                 570                 575     


Arg Ser Lys Ile Arg Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu 
            580                 585                 590         


Arg Arg Leu Gln Val Leu Lys Ser Thr Gly Asp Val Ala Gly Gly Arg 
        595                 600                 605             


Ala Leu Tyr Glu Gly Tyr Ala Thr Val Thr Asp Ala Pro Pro Glu Cys 
    610                 615                 620                 


Phe Leu Thr Leu Arg Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys 
625                 630                 635                 640 


Leu Ile Val Gln Pro Asn Thr Arg Leu Glu Gly Ser Asp Val Gln Leu 
                645                 650                 655     


Leu Glu Tyr Glu Ala Ser Ala Ala Gly Leu Ile Arg Ser Phe Ser Glu 
            660                 665                 670         


Arg Phe Pro Glu Asp Gly Pro Glu Leu Glu Glu Ile Leu Thr Gln Leu 
        675                 680                 685             


Ala Thr Ala Asp Ala Arg Phe Trp Lys Gly Pro Ser Glu Ala Pro Ser 
    690                 695                 700                 


Gly Gln Ala 
705         


<210>  3240
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPP4__Homo_sapiens__NP_001926

<400>  3240

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  3241
<211>  801
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPP6__Homo_sapiens__NP_001034439

<400>  3241

Met Lys Glu Lys Ala Met Ile Lys Thr Ala Lys Met Gln Gly Asn Val 
1               5                   10                  15      


Met Glu Leu Val Gly Ser Asn Pro Pro Gln Arg Asn Trp Lys Gly Ile 
            20                  25                  30          


Ala Ile Ala Leu Leu Val Ile Leu Val Ile Cys Ser Leu Ile Val Thr 
        35                  40                  45              


Ser Val Ile Leu Leu Thr Pro Ala Glu Asp Asn Ser Leu Ser Gln Lys 
    50                  55                  60                  


Lys Lys Val Thr Val Glu Asp Leu Phe Ser Glu Asp Phe Lys Ile His 
65                  70                  75                  80  


Asp Pro Glu Ala Lys Trp Ile Ser Asp Thr Glu Phe Ile Tyr Arg Glu 
                85                  90                  95      


Gln Lys Gly Thr Val Arg Leu Trp Asn Val Glu Thr Asn Thr Ser Thr 
            100                 105                 110         


Val Leu Ile Glu Gly Lys Lys Ile Glu Ser Leu Arg Ala Ile Arg Tyr 
        115                 120                 125             


Glu Ile Ser Pro Asp Arg Glu Tyr Ala Leu Phe Ser Tyr Asn Val Glu 
    130                 135                 140                 


Pro Ile Tyr Gln His Ser Tyr Thr Gly Tyr Tyr Val Leu Ser Lys Ile 
145                 150                 155                 160 


Pro His Gly Asp Pro Gln Ser Leu Asp Pro Pro Glu Val Ser Asn Ala 
                165                 170                 175     


Lys Leu Gln Tyr Ala Gly Trp Gly Pro Lys Gly Gln Gln Leu Ile Phe 
            180                 185                 190         


Ile Phe Glu Asn Asn Ile Tyr Tyr Cys Ala His Val Gly Lys Gln Ala 
        195                 200                 205             


Ile Arg Val Val Ser Thr Gly Lys Glu Gly Val Ile Tyr Asn Gly Leu 
    210                 215                 220                 


Ser Asp Trp Leu Tyr Glu Glu Glu Ile Leu Lys Thr His Ile Ala His 
225                 230                 235                 240 


Trp Trp Ser Pro Asp Gly Thr Arg Leu Ala Tyr Ala Ala Ile Asn Asp 
                245                 250                 255     


Ser Arg Val Pro Ile Met Glu Leu Pro Thr Tyr Thr Gly Ser Ile Tyr 
            260                 265                 270         


Pro Thr Val Lys Pro Tyr His Tyr Pro Lys Ala Gly Ser Glu Asn Pro 
        275                 280                 285             


Ser Ile Ser Leu His Val Ile Gly Leu Asn Gly Pro Thr His Asp Leu 
    290                 295                 300                 


Glu Met Met Pro Pro Asp Asp Pro Arg Met Arg Glu Tyr Tyr Ile Thr 
305                 310                 315                 320 


Met Val Lys Trp Ala Thr Ser Thr Lys Val Ala Val Thr Trp Leu Asn 
                325                 330                 335     


Arg Ala Gln Asn Val Ser Ile Leu Thr Leu Cys Asp Ala Thr Thr Gly 
            340                 345                 350         


Val Cys Thr Lys Lys His Glu Asp Glu Ser Glu Ala Trp Leu His Arg 
        355                 360                 365             


Gln Asn Glu Glu Pro Val Phe Ser Lys Asp Gly Arg Lys Phe Phe Phe 
    370                 375                 380                 


Ile Arg Ala Ile Pro Gln Gly Gly Arg Gly Lys Phe Tyr His Ile Thr 
385                 390                 395                 400 


Val Ser Ser Ser Gln Pro Asn Ser Ser Asn Asp Asn Ile Gln Ser Ile 
                405                 410                 415     


Thr Ser Gly Asp Trp Asp Val Thr Lys Ile Leu Ala Tyr Asp Glu Lys 
            420                 425                 430         


Gly Asn Lys Ile Tyr Phe Leu Ser Thr Glu Asp Leu Pro Arg Arg Arg 
        435                 440                 445             


Gln Leu Tyr Ser Ala Asn Thr Val Gly Asn Phe Asn Arg Gln Cys Leu 
    450                 455                 460                 


Ser Cys Asp Leu Val Glu Asn Cys Thr Tyr Phe Ser Ala Ser Phe Ser 
465                 470                 475                 480 


His Ser Met Asp Phe Phe Leu Leu Lys Cys Glu Gly Pro Gly Val Pro 
                485                 490                 495     


Met Val Thr Val His Asn Thr Thr Asp Lys Lys Lys Met Phe Asp Leu 
            500                 505                 510         


Glu Thr Asn Glu His Val Lys Lys Ala Ile Asn Asp Arg Gln Met Pro 
        515                 520                 525             


Lys Val Glu Tyr Arg Asp Ile Glu Ile Asp Asp Tyr Asn Leu Pro Met 
    530                 535                 540                 


Gln Ile Leu Lys Pro Ala Thr Phe Thr Asp Thr Thr His Tyr Pro Leu 
545                 550                 555                 560 


Leu Leu Val Val Asp Gly Thr Pro Gly Ser Gln Ser Val Ala Glu Lys 
                565                 570                 575     


Phe Glu Val Ser Trp Glu Thr Val Met Val Ser Ser His Gly Ala Val 
            580                 585                 590         


Val Val Lys Cys Asp Gly Arg Gly Ser Gly Phe Gln Gly Thr Lys Leu 
        595                 600                 605             


Leu His Glu Val Arg Arg Arg Leu Gly Leu Leu Glu Glu Lys Asp Gln 
    610                 615                 620                 


Met Glu Ala Val Arg Thr Met Leu Lys Glu Gln Tyr Ile Asp Arg Thr 
625                 630                 635                 640 


Arg Val Ala Val Phe Gly Lys Asp Tyr Gly Gly Tyr Leu Ser Thr Tyr 
                645                 650                 655     


Ile Leu Pro Ala Lys Gly Glu Asn Gln Gly Gln Thr Phe Thr Cys Gly 
            660                 665                 670         


Ser Ala Leu Ser Pro Ile Thr Asp Phe Lys Leu Tyr Ala Ser Ala Phe 
        675                 680                 685             


Ser Glu Arg Tyr Leu Gly Leu His Gly Leu Asp Asn Arg Ala Tyr Glu 
    690                 695                 700                 


Met Thr Lys Val Ala His Arg Val Ser Ala Leu Glu Glu Gln Gln Phe 
705                 710                 715                 720 


Leu Ile Ile His Pro Thr Ala Asp Glu Lys Ile His Phe Gln His Thr 
                725                 730                 735     


Ala Glu Leu Ile Thr Gln Leu Ile Arg Gly Lys Ala Asn Tyr Ser Leu 
            740                 745                 750         


Gln Ile Tyr Pro Asp Glu Ser His Tyr Phe Thr Ser Ser Ser Leu Lys 
        755                 760                 765             


Gln His Leu Tyr Arg Ser Ile Ile Asn Phe Phe Val Glu Cys Phe Arg 
    770                 775                 780                 


Ile Gln Asp Lys Leu Leu Thr Val Thr Ala Lys Glu Asp Glu Glu Glu 
785                 790                 795                 800 


Asp 
    


<210>  3242
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPP7__Homo_sapiens__NP_037511

<400>  3242

Met Gly Ser Ala Pro Trp Ala Pro Val Leu Leu Leu Ala Leu Gly Leu 
1               5                   10                  15      


Arg Gly Leu Gln Ala Gly Ala Arg Arg Ala Pro Asp Pro Gly Phe Gln 
            20                  25                  30          


Glu Arg Phe Phe Gln Gln Arg Leu Asp His Phe Asn Phe Glu Arg Phe 
        35                  40                  45              


Gly Asn Lys Thr Phe Pro Gln Arg Phe Leu Val Ser Asp Arg Phe Trp 
    50                  55                  60                  


Val Arg Gly Glu Gly Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp 
65                  70                  75                  80  


Val Trp Ala Phe Ala Asn Asn Ser Ala Phe Val Ala Glu Leu Ala Ala 
                85                  90                  95      


Glu Arg Gly Ala Leu Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Lys 
            100                 105                 110         


Ser Leu Pro Phe Gly Ala Gln Ser Thr Gln Arg Gly His Thr Glu Leu 
        115                 120                 125             


Leu Thr Val Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Leu Arg Ala 
    130                 135                 140                 


Leu Arg Arg Asp Leu Gly Ala Gln Asp Ala Pro Ala Ile Ala Phe Gly 
145                 150                 155                 160 


Gly Ser Tyr Gly Gly Met Leu Ser Ala Tyr Leu Arg Met Lys Tyr Pro 
                165                 170                 175     


His Leu Val Ala Gly Ala Leu Ala Ala Ser Ala Pro Val Leu Ala Val 
            180                 185                 190         


Ala Gly Leu Gly Asp Ser Asn Gln Phe Phe Arg Asp Val Thr Ala Asp 
        195                 200                 205             


Phe Glu Gly Gln Ser Pro Lys Cys Thr Gln Gly Val Arg Glu Ala Phe 
    210                 215                 220                 


Arg Gln Ile Lys Asp Leu Phe Leu Gln Gly Ala Tyr Asp Thr Val Arg 
225                 230                 235                 240 


Trp Glu Phe Gly Thr Cys Gln Pro Leu Ser Asp Glu Lys Asp Leu Thr 
                245                 250                 255     


Gln Leu Phe Met Phe Ala Arg Asn Ala Phe Thr Val Leu Ala Met Met 
            260                 265                 270         


Asp Tyr Pro Tyr Pro Thr Asp Phe Leu Gly Pro Leu Pro Ala Asn Pro 
        275                 280                 285             


Val Lys Val Gly Cys Asp Arg Leu Leu Ser Glu Ala Gln Arg Ile Thr 
    290                 295                 300                 


Gly Leu Arg Ala Leu Ala Gly Leu Val Tyr Asn Ala Ser Gly Ser Glu 
305                 310                 315                 320 


His Cys Tyr Asp Ile Tyr Arg Leu Tyr His Ser Cys Ala Asp Pro Thr 
                325                 330                 335     


Gly Cys Gly Thr Gly Pro Asp Ala Arg Ala Trp Asp Tyr Gln Ala Cys 
            340                 345                 350         


Thr Glu Ile Asn Leu Thr Phe Ala Ser Asn Asn Val Thr Asp Met Phe 
        355                 360                 365             


Pro Asp Leu Pro Phe Thr Asp Glu Leu Arg Gln Arg Tyr Cys Leu Asp 
    370                 375                 380                 


Thr Trp Gly Val Trp Pro Arg Pro Asp Trp Leu Leu Thr Ser Phe Trp 
385                 390                 395                 400 


Gly Gly Asp Leu Arg Ala Ala Ser Asn Ile Ile Phe Ser Asn Gly Asn 
                405                 410                 415     


Leu Asp Pro Trp Ala Gly Gly Gly Ile Arg Arg Asn Leu Ser Ala Ser 
            420                 425                 430         


Val Ile Ala Val Thr Ile Gln Gly Gly Ala His His Leu Asp Leu Arg 
        435                 440                 445             


Ala Ser His Pro Glu Asp Pro Ala Ser Val Val Glu Ala Arg Lys Leu 
    450                 455                 460                 


Glu Ala Thr Ile Ile Gly Glu Trp Val Lys Ala Ala Arg Arg Glu Gln 
465                 470                 475                 480 


Gln Pro Ala Leu Arg Gly Gly Pro Arg Leu Ser Leu 
                485                 490         


<210>  3243
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPP8__Homo_sapiens__NP_060213

<400>  3243

Met Ala Ala Ala Met Glu Thr Glu Gln Leu Gly Val Glu Ile Phe Glu 
1               5                   10                  15      


Thr Ala Asp Cys Glu Glu Asn Ile Glu Ser Gln Asp Arg Pro Lys Leu 
            20                  25                  30          


Glu Pro Phe Tyr Val Glu Arg Tyr Ser Trp Ser Gln Leu Lys Lys Leu 
        35                  40                  45              


Leu Ala Asp Thr Arg Lys Tyr His Gly Tyr Met Met Ala Lys Ala Pro 
    50                  55                  60                  


His Asp Phe Met Phe Val Lys Arg Asn Asp Pro Asp Gly Pro His Ser 
65                  70                  75                  80  


Asp Arg Ile Tyr Tyr Leu Ala Met Ser Gly Glu Asn Arg Glu Asn Thr 
                85                  90                  95      


Leu Phe Tyr Ser Glu Ile Pro Lys Thr Ile Asn Arg Ala Ala Val Leu 
            100                 105                 110         


Met Leu Ser Trp Lys Pro Leu Leu Asp Leu Phe Gln Ala Thr Leu Asp 
        115                 120                 125             


Tyr Gly Met Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg Lys Arg 
    130                 135                 140                 


Ile Gly Thr Val Gly Ile Ala Ser Tyr Asp Tyr His Gln Gly Ser Gly 
145                 150                 155                 160 


Thr Phe Leu Phe Gln Ala Gly Ser Gly Ile Tyr His Val Lys Asp Gly 
                165                 170                 175     


Gly Pro Gln Gly Phe Thr Gln Gln Pro Leu Arg Pro Asn Leu Val Glu 
            180                 185                 190         


Thr Ser Cys Pro Asn Ile Arg Met Asp Pro Lys Leu Cys Pro Ala Asp 
        195                 200                 205             


Pro Asp Trp Ile Ala Phe Ile His Ser Asn Asp Ile Trp Ile Ser Asn 
    210                 215                 220                 


Ile Val Thr Arg Glu Glu Arg Arg Leu Thr Tyr Val His Asn Glu Leu 
225                 230                 235                 240 


Ala Asn Met Glu Glu Asp Ala Arg Ser Ala Gly Val Ala Thr Phe Val 
                245                 250                 255     


Leu Gln Glu Glu Phe Asp Arg Tyr Ser Gly Tyr Trp Trp Cys Pro Lys 
            260                 265                 270         


Ala Glu Thr Thr Pro Ser Gly Gly Lys Ile Leu Arg Ile Leu Tyr Glu 
        275                 280                 285             


Glu Asn Asp Glu Ser Glu Val Glu Ile Ile His Val Thr Ser Pro Met 
    290                 295                 300                 


Leu Glu Thr Arg Arg Ala Asp Ser Phe Arg Tyr Pro Lys Thr Gly Thr 
305                 310                 315                 320 


Ala Asn Pro Lys Val Thr Phe Lys Met Ser Glu Ile Met Ile Asp Ala 
                325                 330                 335     


Glu Gly Arg Ile Ile Asp Val Ile Asp Lys Glu Leu Ile Gln Pro Phe 
            340                 345                 350         


Glu Ile Leu Phe Glu Gly Val Glu Tyr Ile Ala Arg Ala Gly Trp Thr 
        355                 360                 365             


Pro Glu Gly Lys Tyr Ala Trp Ser Ile Leu Leu Asp Arg Ser Gln Thr 
    370                 375                 380                 


Arg Leu Gln Ile Val Leu Ile Ser Pro Glu Leu Phe Ile Pro Val Glu 
385                 390                 395                 400 


Asp Asp Val Met Glu Arg Gln Arg Leu Ile Glu Ser Val Pro Asp Ser 
                405                 410                 415     


Val Thr Pro Leu Ile Ile Tyr Glu Glu Thr Thr Asp Ile Trp Ile Asn 
            420                 425                 430         


Ile His Asp Ile Phe His Val Phe Pro Gln Ser His Glu Glu Glu Ile 
        435                 440                 445             


Glu Phe Ile Phe Ala Ser Glu Cys Lys Thr Gly Phe Arg His Leu Tyr 
    450                 455                 460                 


Lys Ile Thr Ser Ile Leu Lys Glu Ser Lys Tyr Lys Arg Ser Ser Gly 
465                 470                 475                 480 


Gly Leu Pro Ala Pro Ser Asp Phe Lys Cys Pro Ile Lys Glu Glu Ile 
                485                 490                 495     


Ala Ile Thr Ser Gly Glu Trp Glu Val Leu Gly Arg His Gly Ser Asn 
            500                 505                 510         


Ile Gln Val Asp Glu Val Arg Arg Leu Val Tyr Phe Glu Gly Thr Lys 
        515                 520                 525             


Asp Ser Pro Leu Glu His His Leu Tyr Val Val Ser Tyr Val Asn Pro 
    530                 535                 540                 


Gly Glu Val Thr Arg Leu Thr Asp Arg Gly Tyr Ser His Ser Cys Cys 
545                 550                 555                 560 


Ile Ser Gln His Cys Asp Phe Phe Ile Ser Lys Tyr Ser Asn Gln Lys 
                565                 570                 575     


Asn Pro His Cys Val Ser Leu Tyr Lys Leu Ser Ser Pro Glu Asp Asp 
            580                 585                 590         


Pro Thr Cys Lys Thr Lys Glu Phe Trp Ala Thr Ile Leu Asp Ser Ala 
        595                 600                 605             


Gly Pro Leu Pro Asp Tyr Thr Pro Pro Glu Ile Phe Ser Phe Glu Ser 
    610                 615                 620                 


Thr Thr Gly Phe Thr Leu Tyr Gly Met Leu Tyr Lys Pro His Asp Leu 
625                 630                 635                 640 


Gln Pro Gly Lys Lys Tyr Pro Thr Val Leu Phe Ile Tyr Gly Gly Pro 
                645                 650                 655     


Gln Val Ala Ile Ala Gly Ala Pro Val Thr Leu Trp Ile Phe Tyr Asp 
            660                 665                 670         


Thr Gly Tyr Thr Glu Arg Tyr Met Gly His Pro Asp Gln Asn Glu Gln 
        675                 680                 685             


Gly Tyr Tyr Leu Gly Ser Val Ala Met Gln Ala Glu Lys Phe Pro Ser 
    690                 695                 700                 


Glu Pro Asn Arg Leu Leu Leu Leu His Gly Phe Leu Asp Glu Asn Val 
705                 710                 715                 720 


His Phe Ala His Thr Ser Ile Leu Leu Ser Phe Leu Val Arg Ala Gly 
                725                 730                 735     


Lys Pro Tyr Asp Leu Gln Ile Tyr Pro Gln Glu Arg His Ser Ile Arg 
            740                 745                 750         


Val Pro Glu Ser Gly Glu His Tyr Glu Leu His Leu Leu His Tyr Leu 
        755                 760                 765             


Gln Glu Asn Leu Gly Ser Arg Ile Ala Ala Leu Lys Val Ile 
    770                 775                 780         


<210>  3244
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPP9__Homo_sapiens__XP_005259730

<400>  3244

Met Arg Lys Val Lys Lys Leu Arg Leu Asp Lys Glu Asn Thr Gly Ser 
1               5                   10                  15      


Trp Arg Ser Phe Ser Leu Asn Ser Glu Gly Ala Glu Arg Met Ala Thr 
            20                  25                  30          


Thr Gly Thr Pro Thr Ala Asp Arg Gly Asp Ala Ala Ala Thr Asp Asp 
        35                  40                  45              


Pro Ala Ala Arg Phe Gln Val Gln Lys His Ser Trp Asp Gly Leu Arg 
    50                  55                  60                  


Ser Ile Ile His Gly Ser Arg Lys Tyr Ser Gly Leu Ile Val Asn Lys 
65                  70                  75                  80  


Ala Pro His Asp Phe Gln Phe Val Gln Lys Thr Asp Glu Ser Gly Pro 
                85                  90                  95      


His Ser His Arg Leu Tyr Tyr Leu Gly Met Pro Tyr Gly Ser Arg Glu 
            100                 105                 110         


Asn Ser Leu Leu Tyr Ser Glu Ile Pro Lys Lys Val Arg Lys Glu Ala 
        115                 120                 125             


Leu Leu Leu Leu Ser Trp Lys Gln Met Leu Asp His Phe Gln Ala Thr 
    130                 135                 140                 


Pro His His Gly Val Tyr Ser Arg Glu Glu Glu Leu Leu Arg Glu Arg 
145                 150                 155                 160 


Lys Arg Leu Gly Val Phe Gly Ile Thr Ser Tyr Asp Phe His Ser Glu 
                165                 170                 175     


Ser Gly Leu Phe Leu Phe Gln Ala Ser Asn Ser Leu Phe His Cys Arg 
            180                 185                 190         


Asp Gly Gly Lys Asn Gly Phe Met Val Ser Pro Met Lys Pro Leu Glu 
        195                 200                 205             


Ile Lys Thr Gln Cys Ser Gly Pro Arg Met Asp Pro Lys Ile Cys Pro 
    210                 215                 220                 


Ala Asp Pro Ala Phe Phe Ser Phe Ile Asn Asn Ser Asp Leu Trp Val 
225                 230                 235                 240 


Ala Asn Ile Glu Thr Gly Glu Glu Arg Arg Leu Thr Phe Cys His Gln 
                245                 250                 255     


Gly Leu Ser Asn Val Leu Asp Asp Pro Lys Ser Ala Gly Val Ala Thr 
            260                 265                 270         


Phe Val Ile Gln Glu Glu Phe Asp Arg Phe Thr Gly Tyr Trp Trp Cys 
        275                 280                 285             


Pro Thr Ala Ser Trp Glu Gly Ser Glu Gly Leu Lys Thr Leu Arg Ile 
    290                 295                 300                 


Leu Tyr Glu Glu Val Asp Glu Ser Glu Val Glu Val Ile His Val Pro 
305                 310                 315                 320 


Ser Pro Ala Leu Glu Glu Arg Lys Thr Asp Ser Tyr Arg Tyr Pro Arg 
                325                 330                 335     


Thr Gly Ser Lys Asn Pro Lys Ile Ala Leu Lys Leu Ala Glu Phe Gln 
            340                 345                 350         


Thr Asp Ser Gln Gly Lys Ile Val Ser Thr Gln Glu Lys Glu Leu Val 
        355                 360                 365             


Gln Pro Phe Ser Ser Leu Phe Pro Lys Val Glu Tyr Ile Ala Arg Ala 
    370                 375                 380                 


Gly Trp Thr Arg Asp Gly Lys Tyr Ala Trp Ala Met Phe Leu Asp Arg 
385                 390                 395                 400 


Pro Gln Gln Trp Leu Gln Leu Val Leu Leu Pro Pro Ala Leu Phe Ile 
                405                 410                 415     


Pro Ser Thr Glu Asn Glu Glu Gln Arg Leu Ala Ser Ala Arg Ala Val 
            420                 425                 430         


Pro Arg Asn Val Gln Pro Tyr Val Val Tyr Glu Glu Val Thr Asn Val 
        435                 440                 445             


Trp Ile Asn Val His Asp Ile Phe Tyr Pro Phe Pro Gln Ser Glu Gly 
    450                 455                 460                 


Glu Asp Glu Leu Cys Phe Leu Arg Ala Asn Glu Cys Lys Thr Gly Phe 
465                 470                 475                 480 


Cys His Leu Tyr Lys Val Thr Ala Val Leu Lys Ser Gln Gly Tyr Asp 
                485                 490                 495     


Trp Ser Glu Pro Phe Ser Pro Gly Glu Asp Glu Phe Lys Cys Pro Ile 
            500                 505                 510         


Lys Glu Glu Ile Ala Leu Thr Ser Gly Glu Trp Glu Val Leu Ala Arg 
        515                 520                 525             


His Gly Ser Lys Ile Trp Val Asn Glu Glu Thr Lys Leu Val Tyr Phe 
    530                 535                 540                 


Gln Gly Thr Lys Asp Thr Pro Leu Glu His His Leu Tyr Val Val Ser 
545                 550                 555                 560 


Tyr Glu Ala Ala Gly Glu Ile Val Arg Leu Thr Thr Pro Gly Phe Ser 
                565                 570                 575     


His Ser Cys Ser Met Ser Gln Asn Phe Asp Met Phe Val Ser His Tyr 
            580                 585                 590         


Ser Ser Val Ser Thr Pro Pro Cys Val His Val Tyr Lys Leu Ser Gly 
        595                 600                 605             


Pro Asp Asp Asp Pro Leu His Lys Gln Pro Arg Phe Trp Ala Ser Met 
    610                 615                 620                 


Met Glu Ala Ala Ser Cys Pro Pro Asp Tyr Val Pro Pro Glu Ile Phe 
625                 630                 635                 640 


His Phe His Thr Arg Ser Asp Val Arg Leu Tyr Gly Met Ile Tyr Lys 
                645                 650                 655     


Pro His Ala Leu Gln Pro Gly Lys Lys His Pro Thr Val Leu Phe Val 
            660                 665                 670         


Tyr Gly Gly Pro Gln Val Gln Leu Val Asn Asn Ser Phe Lys Gly Ile 
        675                 680                 685             


Lys Tyr Leu Arg Leu Asn Thr Leu Ala Ser Leu Gly Tyr Ala Val Val 
    690                 695                 700                 


Val Ile Asp Gly Arg Gly Ser Cys Gln Arg Gly Leu Arg Phe Glu Gly 
705                 710                 715                 720 


Ala Leu Lys Asn Gln Met Gly Gln Val Glu Ile Glu Asp Gln Val Glu 
                725                 730                 735     


Gly Leu Gln Phe Val Ala Glu Lys Tyr Gly Phe Ile Asp Leu Ser Arg 
            740                 745                 750         


Val Ala Ile His Gly Trp Ser Tyr Gly Gly Phe Leu Ser Leu Met Gly 
        755                 760                 765             


Leu Ile His Lys Pro Gln Val Phe Lys Val Ala Ile Ala Gly Ala Pro 
    770                 775                 780                 


Val Thr Val Trp Met Ala Tyr Asp Thr Gly Tyr Thr Glu Arg Tyr Met 
785                 790                 795                 800 


Asp Val Pro Glu Asn Asn Gln His Gly Tyr Glu Ala Gly Ser Val Ala 
                805                 810                 815     


Leu His Val Glu Lys Leu Pro Asn Glu Pro Asn Arg Leu Leu Ile Leu 
            820                 825                 830         


His Gly Phe Leu Asp Glu Asn Val His Phe Phe His Thr Asn Phe Leu 
        835                 840                 845             


Val Ser Gln Leu Ile Arg Ala Gly Lys Pro Tyr Gln Leu Gln Ile Tyr 
    850                 855                 860                 


Pro Asn Glu Arg His Ser Ile Arg Cys Pro Glu Ser Gly Glu His Tyr 
865                 870                 875                 880 


Glu Val Thr Leu Leu His Phe Leu Gln Glu Tyr Leu 
                885                 890         


<210>  3245
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPPA2__Homo_sapiens__NP_620170

<400>  3245

Met Ser Asp Ala Asn Leu Asp Ser Ser Lys Lys Asn Phe Leu Glu Gly 
1               5                   10                  15      


Glu Val Asp Asp Glu Glu Ser Val Ile Leu Thr Leu Val Pro Val Lys 
            20                  25                  30          


Asp Asp Ala Asn Met Glu Gln Met Glu Pro Ser Val Ser Ser Thr Ser 
        35                  40                  45              


Asp Val Lys Leu Glu Lys Pro Lys Lys Tyr Asn Pro Gly His Leu Leu 
    50                  55                  60                  


Gln Thr Asn Glu Gln Phe Thr Ala Pro Gln Lys Ala Arg Cys Lys Ile 
65                  70                  75                  80  


Pro Ala Leu Pro Leu Pro Thr Ile Leu Pro Pro Ile Asn Lys Val Cys 
                85                  90                  95      


Arg Asp Thr Leu Arg Asp Trp Cys Gln Gln Leu Gly Leu Ser Thr Asn 
            100                 105                 110         


Gly Lys Lys Ile Glu Val Tyr Leu Arg Leu His Arg His Ala Tyr Pro 
        115                 120                 125             


Glu Gln Arg Gln Asp Met Pro Glu Met Ser Gln Glu Thr Arg Leu Gln 
    130                 135                 140                 


Arg Cys Ser Arg Lys Arg Lys Ala Val Thr Lys Arg Ala Arg Leu Gln 
145                 150                 155                 160 


Arg Ser Tyr Glu Met Asn Glu Arg Ala Glu Glu Thr Asn Thr Val Glu 
                165                 170                 175     


Val Ile Thr Ser Ala Pro Gly Ala Met Leu Ala Ser Trp Ala Arg Ile 
            180                 185                 190         


Ala Ala Arg Ala Val Gln Pro Lys Ala Leu Asn Ser Cys Ser Ile Pro 
        195                 200                 205             


Val Ser Val Glu Ala Phe Leu Met Gln Ala Ser Gly Val Arg Trp Cys 
    210                 215                 220                 


Val Val His Gly Arg Leu Leu Ser Ala Asp Thr Lys Gly Trp Val Arg 
225                 230                 235                 240 


Leu Gln Phe His Ala Gly Gln Ala Trp Val Pro Thr Thr His Arg Arg 
                245                 250                 255     


Met Ile Ser Leu Phe Leu Leu Pro Ala Cys Ile Phe Pro Ser Pro Gly 
            260                 265                 270         


Ile Glu Asp Asn Met Leu Cys Pro Asp Cys Ala Lys Arg Asn Lys Lys 
        275                 280                 285             


Met Met Lys Arg Leu Met Thr Val Glu Lys 
    290                 295             


<210>  3246
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPPA3__Homo_sapiens__NP_954980

<400>  3246

Met Asp Pro Ser Gln Phe Asn Pro Thr Tyr Ile Pro Gly Ser Pro Gln 
1               5                   10                  15      


Met Leu Thr Glu Glu Asn Ser Arg Asp Asp Ser Gly Ala Ser Gln Ile 
            20                  25                  30          


Ser Ser Glu Thr Leu Ile Lys Asn Leu Ser Asn Leu Thr Ile Asn Ala 
        35                  40                  45              


Ser Ser Glu Ser Val Ser Pro Leu Ser Glu Ala Leu Leu Arg Arg Glu 
    50                  55                  60                  


Ser Val Gly Ala Ala Val Leu Arg Glu Ile Glu Asp Glu Trp Leu Tyr 
65                  70                  75                  80  


Ser Arg Arg Gly Val Arg Thr Leu Leu Ser Val Gln Arg Glu Lys Met 
                85                  90                  95      


Ala Arg Leu Arg Tyr Met Leu Leu Gly Gly Val Arg Thr His Glu Arg 
            100                 105                 110         


Arg Pro Thr Asn Lys Glu Pro Lys Gly Val Lys Lys Glu Ser Arg Pro 
        115                 120                 125             


Phe Lys Cys Pro Cys Ser Phe Cys Val Ser Asn Gly Trp Asp Pro Ser 
    130                 135                 140                 


Glu Asn Ala Arg Ile Gly Asn Gln Asp Thr Lys Pro Leu Gln Pro 
145                 150                 155                 


<210>  3247
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPPA4__Homo_sapiens__NP_060659

<400>  3247

Met Leu Arg Gly Ser Ala Ser Ser Thr Ser Met Glu Lys Ala Lys Gly 
1               5                   10                  15      


Lys Glu Trp Thr Ser Thr Glu Lys Ser Arg Glu Glu Asp Gln Gln Ala 
            20                  25                  30          


Ser Asn Gln Pro Asn Ser Ile Ala Leu Pro Gly Thr Ser Ala Lys Arg 
        35                  40                  45              


Thr Lys Glu Lys Met Ser Ile Lys Gly Ser Lys Val Leu Cys Pro Lys 
    50                  55                  60                  


Lys Lys Ala Glu His Thr Asp Asn Pro Arg Pro Gln Lys Lys Ile Pro 
65                  70                  75                  80  


Ile Pro Pro Leu Pro Ser Lys Leu Pro Pro Val Asn Leu Ile His Arg 
                85                  90                  95      


Asp Ile Leu Arg Ala Trp Cys Gln Gln Leu Lys Leu Ser Ser Lys Gly 
            100                 105                 110         


Gln Lys Leu Asp Ala Tyr Lys Arg Leu Cys Ala Phe Ala Tyr Pro Asn 
        115                 120                 125             


Gln Lys Asp Phe Pro Ser Thr Ala Lys Glu Ala Lys Ile Arg Lys Ser 
    130                 135                 140                 


Leu Gln Lys Lys Leu Lys Val Glu Lys Gly Glu Thr Ser Leu Gln Ser 
145                 150                 155                 160 


Ser Glu Thr His Pro Pro Glu Val Ala Leu Pro Pro Val Gly Glu Pro 
                165                 170                 175     


Pro Ala Leu Glu Asn Ser Thr Ala Leu Leu Glu Gly Val Asn Thr Val 
            180                 185                 190         


Val Val Thr Thr Ser Ala Pro Glu Ala Leu Leu Ala Ser Trp Ala Arg 
        195                 200                 205             


Ile Ser Ala Arg Ala Arg Thr Pro Glu Ala Val Glu Ser Pro Gln Glu 
    210                 215                 220                 


Ala Ser Gly Val Arg Trp Cys Val Val His Gly Lys Ser Leu Pro Ala 
225                 230                 235                 240 


Asp Thr Asp Gly Trp Val His Leu Gln Phe His Ala Gly Gln Ala Trp 
                245                 250                 255     


Val Pro Glu Lys Gln Glu Gly Arg Val Ser Ala Leu Phe Leu Leu Pro 
            260                 265                 270         


Ala Ser Asn Phe Pro Pro Pro His Leu Glu Asp Asn Met Leu Cys Pro 
        275                 280                 285             


Lys Cys Val His Arg Asn Lys Val Leu Ile Lys Ser Leu Gln Trp Glu 
    290                 295                 300                 


<210>  3248
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPT__Homo_sapiens__NP_001928

<400>  3248

Met Asp Leu Ser Leu Leu Trp Val Leu Leu Pro Leu Val Thr Met Ala 
1               5                   10                  15      


Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp 
            20                  25                  30          


Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr 
        35                  40                  45              


Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser 
    50                  55                  60                  


Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr 
65                  70                  75                  80  


Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn 
                85                  90                  95      


Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val 
            100                 105                 110         


Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp 
        115                 120                 125             


Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp 
    130                 135                 140                 


Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile 
145                 150                 155                 160 


Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser 
                165                 170                 175     


Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr 
            180                 185                 190         


Glu Tyr Asp Cys Glu Phe Ala Asn Val 
        195                 200     


<210>  3249
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPY19L2__Homo_sapiens__NP_776173

<400>  3249

Met Arg Lys Gln Gly Val Ser Ser Lys Arg Leu Gln Ser Ser Gly Arg 
1               5                   10                  15      


Ser Gln Ser Lys Gly Arg Arg Gly Ala Ser Leu Ala Arg Glu Pro Glu 
            20                  25                  30          


Val Glu Glu Glu Met Glu Lys Ser Ala Leu Gly Gly Gly Lys Leu Pro 
        35                  40                  45              


Arg Gly Ser Trp Arg Ser Ser Pro Gly Arg Ile Gln Ser Leu Lys Glu 
    50                  55                  60                  


Arg Lys Gly Leu Glu Leu Glu Val Val Ala Lys Thr Phe Leu Leu Gly 
65                  70                  75                  80  


Pro Phe Gln Phe Val Arg Asn Ser Leu Ala Gln Leu Arg Glu Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Ala Arg Arg Phe Ser Ser Arg Thr Thr Leu Gly Ile 
            100                 105                 110         


Ala Val Phe Val Ala Ile Leu His Trp Leu His Leu Val Thr Leu Phe 
        115                 120                 125             


Glu Asn Asp Arg His Phe Ser His Leu Ser Ser Leu Glu Arg Glu Met 
    130                 135                 140                 


Thr Phe Arg Thr Glu Met Gly Leu Tyr Tyr Ser Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Ile Glu Ala Pro Ser Phe Leu Glu Gly Leu Trp Met Ile Met Asn Asp 
                165                 170                 175     


Arg Leu Thr Glu Tyr Pro Leu Ile Ile Asn Ala Ile Lys Arg Phe His 
            180                 185                 190         


Leu Tyr Pro Glu Val Ile Ile Ala Ser Trp Tyr Cys Thr Phe Met Gly 
        195                 200                 205             


Ile Met Asn Leu Phe Gly Leu Glu Thr Lys Thr Cys Trp Asn Val Thr 
    210                 215                 220                 


Arg Ile Glu Pro Leu Asn Glu Val Gln Ser Cys Glu Gly Leu Gly Asp 
225                 230                 235                 240 


Pro Ala Cys Phe Tyr Val Gly Val Ile Phe Ile Leu Asn Gly Leu Met 
                245                 250                 255     


Met Gly Leu Phe Phe Met Tyr Gly Ala Tyr Leu Ser Gly Thr Gln Leu 
            260                 265                 270         


Gly Gly Leu Ile Thr Val Leu Cys Phe Phe Phe Asn His Gly Glu Ala 
        275                 280                 285             


Thr Arg Val Met Trp Thr Pro Pro Leu Arg Glu Ser Phe Ser Tyr Pro 
    290                 295                 300                 


Phe Leu Val Leu Gln Met Cys Ile Leu Thr Leu Ile Leu Arg Thr Ser 
305                 310                 315                 320 


Ser Asn Asp Arg Arg Pro Phe Ile Ala Leu Cys Leu Ser Asn Val Ala 
                325                 330                 335     


Phe Met Leu Pro Trp Gln Phe Ala Gln Phe Ile Leu Phe Thr Gln Ile 
            340                 345                 350         


Ala Ser Leu Phe Pro Met Tyr Val Val Gly Tyr Ile Glu Pro Ser Lys 
        355                 360                 365             


Phe Gln Lys Ile Ile Tyr Met Asn Met Ile Ser Val Thr Leu Ser Phe 
    370                 375                 380                 


Ile Leu Met Phe Gly Asn Ser Met Tyr Leu Ser Ser Tyr Tyr Ser Ser 
385                 390                 395                 400 


Ser Leu Leu Met Thr Trp Ala Ile Ile Leu Lys Arg Asn Glu Ile Gln 
                405                 410                 415     


Lys Leu Gly Val Ser Lys Leu Asn Phe Trp Leu Ile Gln Gly Ser Ala 
            420                 425                 430         


Trp Trp Cys Gly Thr Ile Ile Leu Lys Phe Leu Thr Ser Lys Ile Leu 
        435                 440                 445             


Gly Val Ser Asp His Ile Arg Leu Ser Asp Leu Ile Ala Ala Arg Ile 
    450                 455                 460                 


Leu Arg Tyr Thr Asp Phe Asp Thr Leu Ile Tyr Thr Cys Ala Pro Glu 
465                 470                 475                 480 


Phe Asp Phe Met Glu Lys Ala Thr Pro Leu Arg Tyr Thr Lys Thr Leu 
                485                 490                 495     


Leu Leu Pro Val Val Met Val Ile Thr Cys Phe Ile Phe Lys Lys Thr 
            500                 505                 510         


Val Arg Asp Ile Ser Tyr Val Leu Ala Thr Asn Ile Tyr Leu Arg Lys 
        515                 520                 525             


Gln Leu Leu Glu His Ser Glu Leu Ala Phe His Thr Leu Gln Leu Leu 
    530                 535                 540                 


Val Phe Thr Ala Leu Ala Ile Leu Ile Met Arg Leu Lys Met Phe Leu 
545                 550                 555                 560 


Thr Pro His Met Cys Val Met Ala Ser Leu Ile Cys Ser Arg Gln Leu 
                565                 570                 575     


Phe Gly Trp Leu Phe Arg Arg Val Arg Phe Glu Lys Val Ile Phe Gly 
            580                 585                 590         


Ile Leu Thr Val Met Ser Ile Gln Gly Tyr Ala Asn Leu Arg Asn Gln 
        595                 600                 605             


Trp Ser Ile Ile Gly Glu Phe Asn Asn Leu Pro Gln Glu Glu Leu Leu 
    610                 615                 620                 


Gln Trp Ile Lys Tyr Ser Thr Thr Ser Asp Ala Val Phe Ala Gly Ala 
625                 630                 635                 640 


Met Pro Thr Met Ala Ser Ile Lys Leu Ser Thr Leu His Pro Ile Val 
                645                 650                 655     


Asn His Pro His Tyr Glu Asp Ala Asp Leu Arg Ala Arg Thr Lys Ile 
            660                 665                 670         


Val Tyr Ser Thr Tyr Ser Arg Lys Ser Ala Lys Glu Val Arg Asp Lys 
        675                 680                 685             


Leu Leu Glu Leu His Val Asn Tyr Tyr Val Leu Glu Glu Ala Trp Cys 
    690                 695                 700                 


Val Val Arg Thr Lys Pro Gly Cys Ser Met Leu Glu Ile Trp Asp Val 
705                 710                 715                 720 


Glu Asp Pro Ser Asn Ala Ala Asn Pro Pro Leu Cys Ser Val Leu Leu 
                725                 730                 735     


Glu Asp Ala Arg Pro Tyr Phe Thr Thr Val Phe Gln Asn Ser Val Tyr 
            740                 745                 750         


Arg Val Leu Lys Val Asn 
        755             


<210>  3250
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPY19L3__Homo_sapiens__XP_011524828

<400>  3250

Met Met Ser Ile Arg Gln Arg Arg Glu Ile Arg Ala Thr Glu Val Ser 
1               5                   10                  15      


Glu Asp Phe Pro Ala Gln Glu Glu Asn Val Lys Leu Glu Asn Lys Leu 
            20                  25                  30          


Pro Ser Gly Cys Thr Ser Arg Arg Leu Trp Lys Ile Leu Ser Leu Thr 
        35                  40                  45              


Ile Gly Gly Thr Ile Ala Leu Cys Ile Gly Leu Leu Thr Ser Val Tyr 
    50                  55                  60                  


Leu Ala Thr Leu His Glu Asn Asp Leu Trp Phe Ser Asn Ile Lys Glu 
65                  70                  75                  80  


Val Glu Arg Glu Ile Ser Phe Arg Thr Glu Cys Gly Leu Tyr Tyr Ser 
                85                  90                  95      


Tyr Tyr Lys Gln Met Leu Gln Ala Pro Thr Leu Val Gln Gly Phe His 
            100                 105                 110         


Gly Leu Ile Tyr Asp Asn Lys Thr Glu Ser Met Lys Thr Ile Asn Leu 
        115                 120                 125             


Leu Gln Arg Met Asn Ile Tyr Gln Glu Val Phe Leu Ser Ile Leu Tyr 
    130                 135                 140                 


Arg Val Leu Pro Ile Gln Lys Tyr Leu Glu Pro Val Tyr Phe Tyr Ile 
145                 150                 155                 160 


Tyr Thr Leu Phe Gly Leu Gln Ala Ile Tyr Val Thr Ala Leu Tyr Ile 
                165                 170                 175     


Thr Ser Trp Leu Leu Ser Gly Thr Trp Leu Ser Gly Leu Leu Ala Ala 
            180                 185                 190         


Phe Trp Tyr Val Thr Asn Arg Ile Asp Thr Thr Arg Val Glu Phe Thr 
        195                 200                 205             


Ile Pro Leu Arg Glu Asn Trp Ala Leu Pro Phe Phe Ala Ile Gln Ile 
    210                 215                 220                 


Ala Ala Ile Thr Tyr Phe Leu Arg Pro Asn Leu Gln Pro Leu Ser Glu 
225                 230                 235                 240 


Arg Leu Thr Leu Leu Ala Ile Phe Ile Ser Thr Phe Leu Phe Ser Leu 
                245                 250                 255     


Thr Trp Gln Phe Asn Gln Phe Met Met Leu Met Gln Ala Leu Val Leu 
            260                 265                 270         


Phe Thr Leu Asp Ser Leu Asp Met Leu Pro Ala Val Lys Ala Thr Trp 
        275                 280                 285             


Leu Tyr Gly Ile Gln Ile Thr Ser Leu Leu Leu Val Cys Ile Leu Gln 
    290                 295                 300                 


Phe Phe Asn Ser Met Ile Leu Gly Ser Leu Leu Ile Ser Phe Asn Leu 
305                 310                 315                 320 


Ser Val Phe Ile Ala Arg Lys Leu Gln Lys Asn Leu Lys Thr Gly Ser 
                325                 330                 335     


Phe Leu Asn Arg Leu Gly Lys Leu Leu Leu His Leu Phe Met Val Leu 
            340                 345                 350         


Cys Leu Thr Leu Phe Leu Asn Asn Ile Ile Lys Lys Ile Leu Asn Leu 
        355                 360                 365             


Lys Ser Asp Glu His Ile Phe Lys Phe Leu Lys Ala Lys Phe Gly Leu 
    370                 375                 380                 


Gly Ala Thr Arg Asp Phe Asp Ala Asn Leu Tyr Leu Cys Glu Glu Ala 
385                 390                 395                 400 


Phe Gly Leu Leu Pro Phe Asn Thr Phe Gly Arg Leu Ser Asp Thr Leu 
                405                 410                 415     


Leu Phe Tyr Ala Tyr Ile Phe Val Leu Ser Ile Thr Val Ile Val Ala 
            420                 425                 430         


Phe Val Val Ala Phe His Asn Leu Ser Asp Ser Thr Asn Gln Gln Ser 
        435                 440                 445             


Val Gly Lys Met Glu Lys Gly Thr Val Asp Leu Lys Pro Glu Thr Ala 
    450                 455                 460                 


Tyr Asn Leu Ile His Thr Ile Leu Phe Gly Phe Leu Ala Leu Ser Thr 
465                 470                 475                 480 


Met Arg Met Lys Tyr Leu Trp Thr Ser His Met Cys Val Phe Ala Ser 
                485                 490                 495     


Phe Gly Leu Cys Ser Pro Glu Ile Trp Glu Leu Leu Leu Lys Ser Val 
            500                 505                 510         


His Leu Tyr Asn Pro Lys Arg Ile Cys Ile Met Arg Tyr Ser Val Pro 
        515                 520                 525             


Ile Leu Ile Leu Leu Tyr Leu Cys Tyr Lys Phe Trp Pro Gly Met Met 
    530                 535                 540                 


Asp Glu Leu Ser Glu Leu Arg Glu Phe Tyr Asp Pro Asp Thr Val Glu 
545                 550                 555                 560 


Leu Met Asn Trp Ile Asn Ser Asn Thr Pro Arg Lys Ala Val Phe Ala 
                565                 570                 575     


Gly Ser Met Gln Leu Leu Ala Gly Val Lys Leu Cys Thr Gly Arg Thr 
            580                 585                 590         


Leu Thr Asn His Pro His Tyr Glu Asp Ser Ser Leu Arg Glu Arg Thr 
        595                 600                 605             


Arg Ala Val Tyr Gln Ile Tyr Ala Lys Arg Ala Pro Glu Glu Val His 
    610                 615                 620                 


Ala Leu Leu Arg Ser Phe Gly Thr Asp Tyr Val Ile Leu Glu Asp Ser 
625                 630                 635                 640 


Ile Cys Tyr Glu Arg Arg His Arg Arg Gly Cys Arg Leu Arg Asp Leu 
                645                 650                 655     


Leu Asp Ile Ala Asn Gly His Met Met Asp Gly Pro Gly Glu Asn Asp 
            660                 665                 670         


Pro Asp Leu Lys Pro Ala Asp His Pro Arg Phe Cys Glu Glu Ile Lys 
        675                 680                 685             


Arg Asn Leu Pro Pro Tyr Val Ala Tyr Phe Thr Arg Val Phe Gln Asn 
    690                 695                 700                 


Lys Thr Phe His Val Tyr Lys Leu Ser Arg Asn Lys 
705                 710                 715     


<210>  3251
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPY30__Homo_sapiens__NP_115963

<400>  3251

Met Glu Pro Glu Gln Met Leu Glu Gly Gln Thr Gln Val Ala Glu Asn 
1               5                   10                  15      


Pro His Ser Glu Tyr Gly Leu Thr Asp Asn Val Glu Arg Ile Val Glu 
            20                  25                  30          


Asn Glu Lys Ile Asn Ala Glu Lys Ser Ser Lys Gln Lys Val Asp Leu 
        35                  40                  45              


Gln Ser Leu Pro Thr Arg Ala Tyr Leu Asp Gln Thr Val Val Pro Ile 
    50                  55                  60                  


Leu Leu Gln Gly Leu Ala Val Leu Ala Lys Glu Arg Pro Pro Asn Pro 
65                  70                  75                  80  


Ile Glu Phe Leu Ala Ser Tyr Leu Leu Lys Asn Lys Ala Gln Phe Glu 
                85                  90                  95      


Asp Arg Asn 
            


<210>  3252
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPYS__Homo_sapiens__NP_001376

<400>  3252

Met Ala Ala Pro Ser Arg Leu Leu Ile Arg Gly Gly Arg Val Val Asn 
1               5                   10                  15      


Asp Asp Phe Ser Glu Val Ala Asp Val Leu Val Glu Asp Gly Val Val 
            20                  25                  30          


Arg Ala Leu Gly His Asp Leu Leu Pro Pro Gly Gly Ala Pro Ala Gly 
        35                  40                  45              


Leu Arg Val Leu Asp Ala Ala Gly Lys Leu Val Leu Pro Gly Gly Ile 
    50                  55                  60                  


Asp Thr His Thr His Met Gln Phe Pro Phe Met Gly Ser Arg Ser Ile 
65                  70                  75                  80  


Asp Asp Phe His Gln Gly Thr Lys Ala Ala Leu Ser Gly Gly Thr Thr 
                85                  90                  95      


Met Ile Ile Asp Phe Ala Ile Pro Gln Lys Gly Gly Ser Leu Ile Glu 
            100                 105                 110         


Ala Phe Glu Thr Trp Arg Ser Trp Ala Asp Pro Lys Val Cys Cys Asp 
        115                 120                 125             


Tyr Ser Leu His Val Ala Val Thr Trp Trp Ser Asp Gln Val Lys Glu 
    130                 135                 140                 


Glu Met Lys Ile Leu Val Gln Asp Lys Gly Val Asn Ser Phe Lys Met 
145                 150                 155                 160 


Phe Met Ala Tyr Lys Asp Leu Tyr Met Val Thr Asp Leu Glu Leu Tyr 
                165                 170                 175     


Glu Ala Phe Ser Arg Cys Lys Glu Ile Gly Ala Ile Ala Gln Val His 
            180                 185                 190         


Ala Glu Asn Gly Asp Leu Ile Ala Glu Gly Ala Lys Lys Met Leu Ala 
        195                 200                 205             


Leu Gly Ile Thr Gly Pro Glu Gly His Glu Leu Cys Arg Pro Glu Ala 
    210                 215                 220                 


Val Glu Ala Glu Ala Thr Leu Arg Ala Ile Thr Ile Ala Ser Ala Val 
225                 230                 235                 240 


Asn Cys Pro Leu Tyr Ile Val His Val Met Ser Lys Ser Ala Ala Lys 
                245                 250                 255     


Val Ile Ala Asp Ala Arg Arg Asp Gly Lys Val Val Tyr Gly Glu Pro 
            260                 265                 270         


Ile Ala Ala Ser Leu Gly Thr Asp Gly Thr His Tyr Trp Asn Lys Glu 
        275                 280                 285             


Trp His His Ala Ala His His Val Met Gly Pro Pro Leu Arg Pro Asp 
    290                 295                 300                 


Pro Ser Thr Pro Asp Phe Leu Met Asn Leu Leu Ala Asn Asp Asp Leu 
305                 310                 315                 320 


Thr Thr Thr Gly Thr Asp Asn Cys Thr Phe Asn Thr Cys Gln Lys Ala 
                325                 330                 335     


Leu Gly Lys Asp Asp Phe Thr Lys Ile Pro Asn Gly Val Asn Gly Val 
            340                 345                 350         


Glu Asp Arg Met Ser Val Ile Trp Glu Lys Gly Val His Ser Gly Lys 
        355                 360                 365             


Met Asp Glu Asn Arg Phe Val Ala Val Thr Ser Thr Asn Ala Ala Lys 
    370                 375                 380                 


Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ala Val Gly Ser Asp 
385                 390                 395                 400 


Ala Asp Ile Val Ile Trp Asp Pro Lys Gly Thr Arg Thr Ile Ser Ala 
                405                 410                 415     


Lys Thr His His Gln Ala Val Asn Phe Asn Ile Phe Glu Gly Met Val 
            420                 425                 430         


Cys His Gly Val Pro Leu Val Thr Ile Ser Arg Gly Lys Val Val Tyr 
        435                 440                 445             


Glu Ala Gly Val Phe Ser Val Thr Ala Gly Asp Gly Lys Phe Ile Pro 
    450                 455                 460                 


Arg Lys Pro Phe Ala Glu Tyr Ile Tyr Lys Arg Ile Lys Gln Arg Asp 
465                 470                 475                 480 


Arg Thr Cys Thr Pro Thr Pro Val Glu Arg Ala Pro Tyr Lys Gly Glu 
                485                 490                 495     


Val Ala Thr Leu Lys Ser Arg Val Thr Lys Glu Asp Ala Thr Ala Gly 
            500                 505                 510         


Thr Arg Lys Gln Ala His Pro 
        515                 


<210>  3253
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPYSL2__Homo_sapiens__NP_001184222

<400>  3253

Met Ala Glu Arg Lys Gln Ser Gly Lys Ala Ala Glu Asp Glu Glu Val 
1               5                   10                  15      


Pro Ala Phe Phe Lys Asn Leu Gly Ser Gly Ser Pro Lys Pro Arg Gln 
            20                  25                  30          


Lys Phe Cys Gly Met Phe Cys Pro Val Glu Gly Ser Ser Glu Asn Lys 
        35                  40                  45              


Thr Ile Asp Phe Asp Ser Leu Ser Val Gly Arg Gly Ser Gly Gln Val 
    50                  55                  60                  


Val Ala Gln Gln Arg Asp Val Ala His Leu Gly Pro Asp Pro Gln Pro 
65                  70                  75                  80  


Pro Tyr Ser Arg Gln Gly Arg Arg Ala Gly Gly Glu Pro Ser Val Glu 
                85                  90                  95      


Ser Gly Arg Lys Val Glu Ile Arg Arg Ala Ser Gly Lys Glu Ala Leu 
            100                 105                 110         


Gln Asn Ile Asn Asp Gln Ser Asp Arg Leu Leu Ile Lys Gly Gly Lys 
        115                 120                 125             


Ile Val Asn Asp Asp Gln Ser Phe Tyr Ala Asp Ile Tyr Met Glu Asp 
    130                 135                 140                 


Gly Leu Ile Lys Gln Ile Gly Glu Asn Leu Ile Val Pro Gly Gly Val 
145                 150                 155                 160 


Lys Thr Ile Glu Ala His Ser Arg Met Val Ile Pro Gly Gly Ile Asp 
                165                 170                 175     


Val His Thr Arg Phe Gln Met Pro Asp Gln Gly Met Thr Ser Ala Asp 
            180                 185                 190         


Asp Phe Phe Gln Gly Thr Lys Ala Ala Leu Ala Gly Gly Thr Thr Met 
        195                 200                 205             


Ile Ile Asp His Val Val Pro Glu Pro Gly Thr Ser Leu Leu Ala Ala 
    210                 215                 220                 


Phe Asp Gln Trp Arg Glu Trp Ala Asp Ser Lys Ser Cys Cys Asp Tyr 
225                 230                 235                 240 


Ser Leu His Val Asp Ile Ser Glu Trp His Lys Gly Ile Gln Glu Glu 
                245                 250                 255     


Met Glu Ala Leu Val Lys Asp His Gly Val Asn Ser Phe Leu Val Tyr 
            260                 265                 270         


Met Ala Phe Lys Asp Arg Phe Gln Leu Thr Asp Cys Gln Ile Tyr Glu 
        275                 280                 285             


Val Leu Ser Val Ile Arg Asp Ile Gly Ala Ile Ala Gln Val His Ala 
    290                 295                 300                 


Glu Asn Gly Asp Ile Ile Ala Glu Glu Gln Gln Arg Ile Leu Asp Leu 
305                 310                 315                 320 


Gly Ile Thr Gly Pro Glu Gly His Val Leu Ser Arg Pro Glu Glu Val 
                325                 330                 335     


Glu Ala Glu Ala Val Asn Arg Ala Ile Thr Ile Ala Asn Gln Thr Asn 
            340                 345                 350         


Cys Pro Leu Tyr Ile Thr Lys Val Met Ser Lys Ser Ser Ala Glu Val 
        355                 360                 365             


Ile Ala Gln Ala Arg Lys Lys Gly Thr Val Val Tyr Gly Glu Pro Ile 
    370                 375                 380                 


Thr Ala Ser Leu Gly Thr Asp Gly Ser His Tyr Trp Ser Lys Asn Trp 
385                 390                 395                 400 


Ala Lys Ala Ala Ala Phe Val Thr Ser Pro Pro Leu Ser Pro Asp Pro 
                405                 410                 415     


Thr Thr Pro Asp Phe Leu Asn Ser Leu Leu Ser Cys Gly Asp Leu Gln 
            420                 425                 430         


Val Thr Gly Ser Ala His Cys Thr Phe Asn Thr Ala Gln Lys Ala Val 
        435                 440                 445             


Gly Lys Asp Asn Phe Thr Leu Ile Pro Glu Gly Thr Asn Gly Thr Glu 
    450                 455                 460                 


Glu Arg Met Ser Val Ile Trp Asp Lys Ala Val Val Thr Gly Lys Met 
465                 470                 475                 480 


Asp Glu Asn Gln Phe Val Ala Val Thr Ser Thr Asn Ala Ala Lys Val 
                485                 490                 495     


Phe Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ala Val Gly Ser Asp Ala 
            500                 505                 510         


Asp Leu Val Ile Trp Asp Pro Asp Ser Val Lys Thr Ile Ser Ala Lys 
        515                 520                 525             


Thr His Asn Ser Ser Leu Glu Tyr Asn Ile Phe Glu Gly Met Glu Cys 
    530                 535                 540                 


Arg Gly Ser Pro Leu Val Val Ile Ser Gln Gly Lys Ile Val Leu Glu 
545                 550                 555                 560 


Asp Gly Thr Leu His Val Thr Glu Gly Ser Gly Arg Tyr Ile Pro Arg 
                565                 570                 575     


Lys Pro Phe Pro Asp Phe Val Tyr Lys Arg Ile Lys Ala Arg Ser Arg 
            580                 585                 590         


Leu Ala Glu Leu Arg Gly Val Pro Arg Gly Leu Tyr Asp Gly Pro Val 
        595                 600                 605             


Cys Glu Val Ser Val Thr Pro Lys Thr Val Thr Pro Ala Ser Ser Ala 
    610                 615                 620                 


Lys Thr Ser Pro Ala Lys Gln Gln Ala Pro Pro Val Arg Asn Leu His 
625                 630                 635                 640 


Gln Ser Gly Phe Ser Leu Ser Gly Ala Gln Ile Asp Asp Asn Ile Pro 
                645                 650                 655     


Arg Arg Thr Thr Gln Arg Ile Val Ala Pro Pro Gly Gly Arg Ala Asn 
            660                 665                 670         


Ile Thr Ser Leu Gly 
        675         


<210>  3254
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPYSL3__Homo_sapiens__NP_001184223

<400>  3254

Met Ala Ser Gly Arg Arg Gly Trp Asp Ser Ser His Glu Asp Asp Leu 
1               5                   10                  15      


Pro Val Tyr Leu Ala Arg Pro Gly Thr Thr Asp Gln Val Pro Arg Gln 
            20                  25                  30          


Lys Tyr Gly Gly Met Phe Cys Asn Val Glu Gly Ala Phe Glu Ser Lys 
        35                  40                  45              


Thr Leu Asp Phe Asp Ala Leu Ser Val Gly Gln Arg Gly Ala Lys Thr 
    50                  55                  60                  


Pro Arg Ser Gly Gln Gly Ser Asp Arg Gly Ser Gly Ser Arg Pro Gly 
65                  70                  75                  80  


Ile Glu Gly Asp Thr Pro Arg Arg Gly Gln Gly Arg Glu Glu Ser Arg 
                85                  90                  95      


Glu Pro Ala Pro Ala Ser Pro Ala Pro Ala Gly Val Glu Ile Arg Ser 
            100                 105                 110         


Ala Thr Gly Lys Glu Val Leu Gln Asn Leu Gly Pro Lys Asp Lys Ser 
        115                 120                 125             


Asp Arg Leu Leu Ile Lys Gly Gly Arg Ile Val Asn Asp Asp Gln Ser 
    130                 135                 140                 


Phe Tyr Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly 
145                 150                 155                 160 


Asp Asn Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly 
                165                 170                 175     


Lys Met Val Ile Pro Gly Gly Ile Asp Val His Thr His Phe Gln Met 
            180                 185                 190         


Pro Tyr Lys Gly Met Thr Thr Val Asp Asp Phe Phe Gln Gly Thr Lys 
        195                 200                 205             


Ala Ala Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro 
    210                 215                 220                 


Glu Pro Glu Ser Ser Leu Thr Glu Ala Tyr Glu Lys Trp Arg Glu Trp 
225                 230                 235                 240 


Ala Asp Gly Lys Ser Cys Cys Asp Tyr Ala Leu His Val Asp Ile Thr 
                245                 250                 255     


His Trp Asn Asp Ser Val Lys Gln Glu Val Gln Asn Leu Ile Lys Asp 
            260                 265                 270         


Lys Gly Val Asn Ser Phe Met Val Tyr Met Ala Tyr Lys Asp Leu Tyr 
        275                 280                 285             


Gln Val Ser Asn Thr Glu Leu Tyr Glu Ile Phe Thr Cys Leu Gly Glu 
    290                 295                 300                 


Leu Gly Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala 
305                 310                 315                 320 


Gln Glu Gln Thr Arg Met Leu Glu Met Gly Ile Thr Gly Pro Glu Gly 
                325                 330                 335     


His Val Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg 
            340                 345                 350         


Ala Ile Thr Ile Ala Ser Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys 
        355                 360                 365             


Val Met Ser Lys Ser Ala Ala Asp Leu Ile Ser Gln Ala Arg Lys Lys 
    370                 375                 380                 


Gly Asn Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Ile Asp 
385                 390                 395                 400 


Gly Thr His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val 
                405                 410                 415     


Thr Ser Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Ile Asn 
            420                 425                 430         


Ser Leu Leu Ala Ser Gly Asp Leu Gln Leu Ser Gly Ser Ala His Cys 
        435                 440                 445             


Thr Phe Ser Thr Ala Gln Lys Ala Ile Gly Lys Asp Asn Phe Thr Ala 
    450                 455                 460                 


Ile Pro Glu Gly Thr Asn Gly Val Glu Glu Arg Met Ser Val Ile Trp 
465                 470                 475                 480 


Asp Lys Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala 
                485                 490                 495     


Val Thr Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys 
            500                 505                 510         


Gly Arg Ile Ser Val Gly Ser Asp Ser Asp Leu Val Ile Trp Asp Pro 
        515                 520                 525             


Asp Ala Val Lys Ile Val Ser Ala Lys Asn His Gln Ser Ala Ala Glu 
    530                 535                 540                 


Tyr Asn Ile Phe Glu Gly Met Glu Leu Arg Gly Ala Pro Leu Val Val 
545                 550                 555                 560 


Ile Cys Gln Gly Lys Ile Met Leu Glu Asp Gly Asn Leu His Val Thr 
                565                 570                 575     


Gln Gly Ala Gly Arg Phe Ile Pro Cys Ser Pro Phe Ser Asp Tyr Val 
            580                 585                 590         


Tyr Lys Arg Ile Lys Ala Arg Arg Lys Met Ala Asp Leu His Ala Val 
        595                 600                 605             


Pro Arg Gly Met Tyr Asp Gly Pro Val Phe Asp Leu Thr Thr Thr Pro 
    610                 615                 620                 


Lys Gly Gly Thr Pro Ala Gly Ser Ala Arg Gly Ser Pro Thr Arg Pro 
625                 630                 635                 640 


Asn Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly 
                645                 650                 655     


Thr Gln Val Asp Glu Gly Val Arg Ser Ala Ser Lys Arg Ile Val Ala 
            660                 665                 670         


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
        675                 680                 


<210>  3255
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPYSL4__Homo_sapiens__NP_006417

<400>  3255

Met Ser Phe Gln Gly Lys Lys Ser Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Arg Gly Gly Arg Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Val His Val Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Ile Lys Thr Ile Asp Ala His Gly Leu Met 
    50                  55                  60                  


Val Leu Pro Gly Gly Val Asp Val His Thr Arg Leu Gln Met Pro Val 
65                  70                  75                  80  


Leu Gly Met Thr Pro Ala Asp Asp Phe Cys Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Leu Asp His Val Phe Pro Asp Thr 
            100                 105                 110         


Gly Val Ser Leu Leu Ala Ala Tyr Glu Gln Trp Arg Glu Arg Ala Asp 
        115                 120                 125             


Ser Ala Ala Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Arg Trp 
    130                 135                 140                 


His Glu Ser Ile Lys Glu Glu Leu Glu Ala Leu Val Lys Glu Lys Gly 
145                 150                 155                 160 


Val Asn Ser Phe Leu Val Phe Met Ala Tyr Lys Asp Arg Cys Gln Cys 
                165                 170                 175     


Ser Asp Ser Gln Met Tyr Glu Ile Phe Ser Ile Ile Arg Asp Leu Gly 
            180                 185                 190         


Ala Leu Ala Gln Val His Ala Glu Asn Gly Asp Ile Val Glu Glu Glu 
        195                 200                 205             


Gln Lys Arg Leu Leu Glu Leu Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr Arg Ala Val 
225                 230                 235                 240 


Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr Lys Val Met 
                245                 250                 255     


Ser Lys Gly Ala Ala Asp Ala Ile Ala Gln Ala Lys Arg Arg Gly Val 
            260                 265                 270         


Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Val Asn Pro Asp Pro Thr Thr Ala Asp His Leu Thr Cys Leu 
305                 310                 315                 320 


Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Ala Leu Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Ile Glu Glu Arg Met Ser Met Val Trp Glu Lys 
        355                 360                 365             


Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn Pro Lys Ala 
                405                 410                 415     


Thr Lys Ile Ile Ser Ala Lys Thr His Asn Leu Asn Val Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Val Glu Cys Arg Gly Ala Pro Ala Val Val Ile Ser 
        435                 440                 445             


Gln Gly Arg Val Ala Leu Glu Asp Gly Lys Met Phe Val Thr Pro Gly 
    450                 455                 460                 


Ala Gly Arg Phe Val Pro Arg Lys Thr Phe Pro Asp Phe Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly Val Pro Arg 
                485                 490                 495     


Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Val Pro Ala Lys Pro 
            500                 505                 510         


Gly Ser Gly Ala Pro Ala Arg Ala Ser Cys Pro Gly Lys Ile Ser Val 
        515                 520                 525             


Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ser 
    530                 535                 540                 


Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys Ile Met Ala 
545                 550                 555                 560 


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
                565                 570         


<210>  3256
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPYSL5__Homo_sapiens__NP_001240652

<400>  3256

Met Leu Ala Asn Ser Ala Ser Val Arg Ile Leu Ile Lys Gly Gly Lys 
1               5                   10                  15      


Val Val Asn Asp Asp Cys Thr His Glu Ala Asp Val Tyr Ile Glu Asn 
            20                  25                  30          


Gly Ile Ile Gln Gln Val Gly Arg Glu Leu Met Ile Pro Gly Gly Ala 
        35                  40                  45              


Lys Val Ile Asp Ala Thr Gly Lys Leu Val Ile Pro Gly Gly Ile Asp 
    50                  55                  60                  


Thr Ser Thr His Phe His Gln Thr Phe Met Asn Ala Thr Cys Val Asp 
65                  70                  75                  80  


Asp Phe Tyr His Gly Thr Lys Ala Ala Leu Val Gly Gly Thr Thr Met 
                85                  90                  95      


Ile Ile Gly His Val Leu Pro Asp Lys Glu Thr Ser Leu Val Asp Ala 
            100                 105                 110         


Tyr Glu Lys Cys Arg Gly Leu Ala Asp Pro Lys Val Cys Cys Asp Tyr 
        115                 120                 125             


Ala Leu His Val Gly Ile Thr Trp Trp Ala Pro Lys Val Lys Ala Glu 
    130                 135                 140                 


Met Glu Thr Leu Val Arg Glu Lys Gly Val Asn Ser Phe Gln Met Phe 
145                 150                 155                 160 


Met Thr Tyr Lys Asp Leu Tyr Met Leu Arg Asp Ser Glu Leu Tyr Gln 
                165                 170                 175     


Val Leu His Ala Cys Lys Asp Ile Gly Ala Ile Ala Arg Val His Ala 
            180                 185                 190         


Glu Asn Gly Glu Leu Val Ala Glu Gly Ala Lys Glu Ala Leu Asp Leu 
        195                 200                 205             


Gly Ile Thr Gly Pro Glu Gly Ile Glu Ile Ser Arg Pro Glu Glu Leu 
    210                 215                 220                 


Glu Ala Glu Ala Thr His Arg Val Ile Thr Ile Ala Asn Arg Thr His 
225                 230                 235                 240 


Cys Pro Ile Tyr Leu Val Asn Val Ser Ser Ile Ser Ala Gly Asp Val 
                245                 250                 255     


Ile Ala Ala Ala Lys Met Gln Gly Lys Val Val Leu Ala Glu Thr Thr 
            260                 265                 270         


Thr Ala His Ala Thr Leu Thr Gly Leu His Tyr Tyr His Gln Asp Trp 
        275                 280                 285             


Ser His Ala Ala Ala Tyr Val Thr Val Pro Pro Leu Arg Leu Asp Thr 
    290                 295                 300                 


Asn Thr Ser Thr Tyr Leu Met Ser Leu Leu Ala Asn Asp Thr Leu Asn 
305                 310                 315                 320 


Ile Val Ala Ser Asp His Arg Pro Phe Thr Thr Lys Gln Lys Ala Met 
                325                 330                 335     


Gly Lys Glu Asp Phe Thr Lys Ile Pro His Gly Val Ser Gly Val Gln 
            340                 345                 350         


Asp Arg Met Ser Val Ile Trp Glu Arg Gly Val Val Gly Gly Lys Met 
        355                 360                 365             


Asp Glu Asn Arg Phe Val Ala Val Thr Ser Ser Asn Ala Ala Lys Leu 
    370                 375                 380                 


Leu Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ile Pro Gly Ala Asp Ala 
385                 390                 395                 400 


Asp Val Val Val Trp Asp Pro Glu Ala Thr Lys Thr Ile Ser Ala Ser 
                405                 410                 415     


Thr Gln Val Gln Gly Gly Asp Phe Asn Leu Tyr Glu Asn Met Arg Cys 
            420                 425                 430         


His Gly Val Pro Leu Val Thr Ile Ser Arg Gly Arg Val Val Tyr Glu 
        435                 440                 445             


Asn Gly Val Phe Met Cys Ala Glu Gly Thr Gly Lys Phe Cys Pro Leu 
    450                 455                 460                 


Arg Ser Phe Pro Asp Thr Val Tyr Lys Lys Leu Val Gln Arg Glu Lys 
465                 470                 475                 480 


Thr Leu Lys Val Arg Gly Val Asp Arg Thr Pro Tyr Leu Gly Asp Val 
                485                 490                 495     


Ala Val Val Val His Pro Gly Lys Lys Glu Met Gly Thr Pro Leu Ala 
            500                 505                 510         


Asp Thr Pro Thr Arg Pro Val Thr Arg His Gly Gly Met Arg Asp Leu 
        515                 520                 525             


His Glu Ser Ser Phe Ser Leu Ser Gly Ser Gln Ile Asp Asp His Val 
    530                 535                 540                 


Pro Lys Arg Ala Ser Ala Arg Ile Leu Ala Pro Pro Gly Gly Arg Ser 
545                 550                 555                 560 


Ser Gly Ile Trp 
                


<210>  3257
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRAM1__Homo_sapiens__NP_060840

<400>  3257

Met Leu Cys Phe Leu Arg Gly Met Ala Phe Val Pro Phe Leu Leu Val 
1               5                   10                  15      


Thr Trp Ser Ser Ala Ala Phe Ile Ile Ser Tyr Val Val Ala Val Leu 
            20                  25                  30          


Ser Gly His Val Asn Pro Phe Leu Pro Tyr Ile Ser Asp Thr Gly Thr 
        35                  40                  45              


Thr Pro Pro Glu Ser Gly Ile Phe Gly Phe Met Ile Asn Phe Ser Ala 
    50                  55                  60                  


Phe Leu Gly Ala Ala Thr Met Tyr Thr Arg Tyr Lys Ile Val Gln Lys 
65                  70                  75                  80  


Gln Asn Gln Thr Cys Tyr Phe Ser Thr Pro Val Phe Asn Leu Val Ser 
                85                  90                  95      


Leu Val Leu Gly Leu Val Gly Cys Phe Gly Met Gly Ile Val Ala Asn 
            100                 105                 110         


Phe Gln Glu Leu Ala Val Pro Val Val His Asp Gly Gly Ala Leu Leu 
        115                 120                 125             


Ala Phe Val Cys Gly Val Val Tyr Thr Leu Leu Gln Ser Ile Ile Ser 
    130                 135                 140                 


Tyr Lys Ser Cys Pro Gln Trp Asn Ser Leu Ser Thr Cys His Ile Arg 
145                 150                 155                 160 


Met Val Ile Ser Ala Val Ser Cys Ala Ala Val Ile Pro Met Ile Val 
                165                 170                 175     


Cys Ala Ser Leu Ile Ser Ile Thr Lys Leu Glu Trp Asn Pro Arg Glu 
            180                 185                 190         


Lys Asp Tyr Val Tyr His Val Val Ser Ala Ile Cys Glu Trp Thr Val 
        195                 200                 205             


Ala Phe Gly Phe Ile Phe Tyr Phe Leu Thr Phe Ile Gln Asp Phe Gln 
    210                 215                 220                 


Ser Val Thr Leu Arg Ile Ser Thr Glu Ile Asn Gly Asp Ile 
225                 230                 235             


<210>  3258
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRAP1__Homo_sapiens__NP_006433

<400>  3258

Met Pro Ser Lys Lys Lys Lys Tyr Asn Ala Arg Phe Pro Pro Ala Arg 
1               5                   10                  15      


Ile Lys Lys Ile Met Gln Thr Asp Glu Glu Ile Gly Lys Val Ala Ala 
            20                  25                  30          


Ala Val Pro Val Ile Ile Ser Arg Ala Leu Glu Leu Phe Leu Glu Ser 
        35                  40                  45              


Leu Leu Lys Lys Ala Cys Gln Val Thr Gln Ser Arg Asn Ala Lys Thr 
    50                  55                  60                  


Met Thr Thr Ser His Leu Lys Gln Cys Ile Glu Leu Glu Gln Gln Phe 
65                  70                  75                  80  


Asp Phe Leu Lys Asp Leu Val Ala Ser Val Pro Asp Met Gln Gly Asp 
                85                  90                  95      


Gly Glu Asp Asn His Met Asp Gly Asp Lys Gly Ala Arg Arg Gly Arg 
            100                 105                 110         


Lys Pro Gly Ser Gly Gly Arg Lys Asn Gly Gly Met Gly Thr Lys Ser 
        115                 120                 125             


Lys Asp Lys Lys Leu Ser Gly Thr Asp Ser Glu Gln Glu Asp Glu Ser 
    130                 135                 140                 


Glu Asp Thr Asp Thr Asp Gly Glu Glu Glu Thr Ser Gln Pro Pro Pro 
145                 150                 155                 160 


Gln Ala Ser His Pro Ser Ala His Phe Gln Ser Pro Pro Thr Pro Phe 
                165                 170                 175     


Leu Pro Phe Ala Ser Thr Leu Pro Leu Pro Pro Ala Pro Pro Gly Pro 
            180                 185                 190         


Ser Ala Pro Asp Glu Glu Asp Glu Glu Asp Tyr Asp Ser 
        195                 200                 205 


<210>  3259
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRC1__Homo_sapiens__NP_659475

<400>  3259

Met Asn Pro Pro Gly Ser Leu Glu Ala Leu Asp Pro Asn Val Asp Glu 
1               5                   10                  15      


His Leu Ser Thr Gln Ile Leu Ala Pro Ser Val His Ser Asp Asn Ser 
            20                  25                  30          


Gln Glu Arg Ile Gln Ala Arg Arg Leu Arg Ile Ala Ala Arg Leu Glu 
        35                  40                  45              


Ala Arg Arg Arg Glu Ala Leu Gly Glu Tyr Leu Asp Gly Lys Lys Glu 
    50                  55                  60                  


Ser Glu Glu Asp Gln Ser Lys Ser Tyr Lys Gln Lys Glu Glu Ser Arg 
65                  70                  75                  80  


Leu Lys Leu Ala Lys Leu Leu Leu Cys Gly Thr Glu Leu Val Thr Asn 
                85                  90                  95      


Ile Gln Val Ala Ile Asp Ile Arg Glu Ile His Arg Arg Val Glu Glu 
            100                 105                 110         


Glu Glu Ile Lys Arg Gln Arg Ile Glu Lys Leu Glu Asn Glu Val Lys 
        115                 120                 125             


Thr Ser Gln Asp Lys Phe Asp Glu Ile Thr Ser Lys Trp Glu Glu Gly 
    130                 135                 140                 


Lys Gln Lys Arg Ile Pro Gln Glu Leu Trp Glu Met Leu Asn Thr Gln 
145                 150                 155                 160 


Gln Leu His Cys Ala Gly Leu Leu Glu Asp Lys Asn Lys Leu Ile Ser 
                165                 170                 175     


Glu Leu Gln Gln Glu Leu Lys Thr Lys Asp Asp Gln Tyr Val Lys Asp 
            180                 185                 190         


Leu Lys Lys Gln Ser Asp Asp Ile Cys Leu Leu Leu Glu Arg Met Glu 
        195                 200                 205             


Glu Gln Val Lys Asn Val Met Lys Thr Phe Arg Glu Glu Leu Tyr Asn 
    210                 215                 220                 


Ile Glu Lys Ala Phe Glu Val Glu Arg Gln Glu Leu Leu Ala Ser Asn 
225                 230                 235                 240 


Lys Lys Lys Trp Glu Gln Ala Leu Gln Ala His Asn Ala Lys Glu Leu 
                245                 250                 255     


Glu Tyr Leu Asn Asn Arg Met Lys Lys Val Glu Asp Tyr Glu Lys Gln 
            260                 265                 270         


Leu Asn Arg Gln Arg Ile Trp Asp Cys Glu Glu Tyr Asn Met Ile Lys 
        275                 280                 285             


Ile Lys Leu Glu Gln Asp Val Gln Ile Leu Glu Gln Gln Leu Gln Gln 
    290                 295                 300                 


Arg Lys Ala Ile Tyr Gln Leu Asn Gln Glu Lys Leu Glu Tyr Asn Leu 
305                 310                 315                 320 


Gln Val Leu Lys Lys Arg Asp Glu Glu Ser Thr Val Ile Lys Ser Gln 
                325                 330                 335     


Gln Lys Arg Lys Ile Asn Arg Leu His Asp Ile Leu Asn Asn Leu Arg 
            340                 345                 350         


Ser Lys Tyr Ala Lys Gln Ile Lys Gln Phe Gln Glu Glu Asn Gln Ser 
        355                 360                 365             


Leu Thr Ser Asp Tyr Lys Arg Leu Val Met Gln Phe Lys Glu Leu Gln 
    370                 375                 380                 


Lys Ala Met Arg His Phe Ala Leu Ile Asp Asp Glu Lys Phe Trp Glu 
385                 390                 395                 400 


Ile Trp Leu Met Asn Glu Glu Glu Ala Lys Asp Leu Ile Ala Arg Ala 
                405                 410                 415     


Phe Asp Val Asp Arg Ile Ile His Thr His His Leu Gly Leu Pro Trp 
            420                 425                 430         


Ala Ala Pro Asp Phe Trp Phe Leu Asn Asn Val Gly Pro Ile Ser Gln 
        435                 440                 445             


Gln Pro Gln Lys Ser Ala Thr Gln Ile Val Glu Glu Met Leu Met Arg 
    450                 455                 460                 


Ser Glu Glu Glu Glu Ala Glu Glu Ala Ala Ala Glu Pro Glu Ser Tyr 
465                 470                 475                 480 


Leu Asp Leu Pro Lys Gln Ile Ser Glu Lys Thr Thr Lys Arg Ile Leu 
                485                 490                 495     


Met Leu Leu Cys Asp Glu Ser Gly Phe Leu Ile Glu Ser Lys Leu Leu 
            500                 505                 510         


Ser Leu Leu Leu Pro Leu Glu Gln Asn Glu Cys Tyr Leu Leu Arg Leu 
        515                 520                 525             


Asp Ala Ile Phe Ser Ala Leu Gly Ile Glu Ser Glu Asp Asp Leu Tyr 
    530                 535                 540                 


Lys Leu Val Asn Phe Phe Leu Lys Tyr Arg Ala His Arg Leu Ser Ser 
545                 550                 555                 560 


Ser Leu Gln Ile Lys Pro Cys Ser Gln Ala Ser Met Glu Lys Ala Ser 
                565                 570                 575     


Met Glu Glu Thr Ser Thr Arg Ser Glu Leu Glu Leu Ala Glu Gln Thr 
            580                 585                 590         


Glu Met Glu Gly Glu Lys Glu Glu Ser Leu Val Glu Gly Glu Lys Glu 
        595                 600                 605             


Glu Glu Glu Glu Thr Pro Pro Ser Pro Trp Val Ile His Pro Asn Asp 
    610                 615                 620                 


Val Leu Lys Ile Leu Glu Ala Phe Val Met Gly Leu Lys Lys Pro Arg 
625                 630                 635                 640 


Asp Ser Arg Ala Pro Leu Arg Val Gln Lys Asn Val Arg Asp Asn Ser 
                645                 650                 655     


Lys Asp Ser Glu Tyr Trp Gln Ala Leu Thr Thr Val Ile Pro Ser Ser 
            660                 665                 670         


Lys Gln Asn Leu Trp Asp Ala Leu Tyr Thr Ala Leu Glu Lys Tyr His 
        675                 680                 685             


Leu Val Leu Thr Gln Arg Ala Lys Leu Leu Leu Glu Asn Ser Ser Leu 
    690                 695                 700                 


Glu Gln Gln Asn Thr Glu Leu Gln Ala Leu Leu Gln Gln Tyr Leu Asn 
705                 710                 715                 720 


Ser Lys Ile Asn Ser Glu Leu Gln Val Pro Pro Thr Gln Val Leu Arg 
                725                 730                 735     


Val Pro Thr Lys 
            740 


<210>  3260
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRD1__Homo_sapiens__NP_000785

<400>  3260

Met Arg Thr Leu Asn Thr Ser Ala Met Asp Gly Thr Gly Leu Val Val 
1               5                   10                  15      


Glu Arg Asp Phe Ser Val Arg Ile Leu Thr Ala Cys Phe Leu Ser Leu 
            20                  25                  30          


Leu Ile Leu Ser Thr Leu Leu Gly Asn Thr Leu Val Cys Ala Ala Val 
        35                  40                  45              


Ile Arg Phe Arg His Leu Arg Ser Lys Val Thr Asn Phe Phe Val Ile 
    50                  55                  60                  


Ser Leu Ala Val Ser Asp Leu Leu Val Ala Val Leu Val Met Pro Trp 
65                  70                  75                  80  


Lys Ala Val Ala Glu Ile Ala Gly Phe Trp Pro Phe Gly Ser Phe Cys 
                85                  90                  95      


Asn Ile Trp Val Ala Phe Asp Ile Met Cys Ser Thr Ala Ser Ile Leu 
            100                 105                 110         


Asn Leu Cys Val Ile Ser Val Asp Arg Tyr Trp Ala Ile Ser Ser Pro 
        115                 120                 125             


Phe Arg Tyr Glu Arg Lys Met Thr Pro Lys Ala Ala Phe Ile Leu Ile 
    130                 135                 140                 


Ser Val Ala Trp Thr Leu Ser Val Leu Ile Ser Phe Ile Pro Val Gln 
145                 150                 155                 160 


Leu Ser Trp His Lys Ala Lys Pro Thr Ser Pro Ser Asp Gly Asn Ala 
                165                 170                 175     


Thr Ser Leu Ala Glu Thr Ile Asp Asn Cys Asp Ser Ser Leu Ser Arg 
            180                 185                 190         


Thr Tyr Ala Ile Ser Ser Ser Val Ile Ser Phe Tyr Ile Pro Val Ala 
        195                 200                 205             


Ile Met Ile Val Thr Tyr Thr Arg Ile Tyr Arg Ile Ala Gln Lys Gln 
    210                 215                 220                 


Ile Arg Arg Ile Ala Ala Leu Glu Arg Ala Ala Val His Ala Lys Asn 
225                 230                 235                 240 


Cys Gln Thr Thr Thr Gly Asn Gly Lys Pro Val Glu Cys Ser Gln Pro 
                245                 250                 255     


Glu Ser Ser Phe Lys Met Ser Phe Lys Arg Glu Thr Lys Val Leu Lys 
            260                 265                 270         


Thr Leu Ser Val Ile Met Gly Val Phe Val Cys Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Ile Leu Asn Cys Ile Leu Pro Phe Cys Gly Ser Gly Glu Thr Gln 
    290                 295                 300                 


Pro Phe Cys Ile Asp Ser Asn Thr Phe Asp Val Phe Val Trp Phe Gly 
305                 310                 315                 320 


Trp Ala Asn Ser Ser Leu Asn Pro Ile Ile Tyr Ala Phe Asn Ala Asp 
                325                 330                 335     


Phe Arg Lys Ala Phe Ser Thr Leu Leu Gly Cys Tyr Arg Leu Cys Pro 
            340                 345                 350         


Ala Thr Asn Asn Ala Ile Glu Thr Val Ser Ile Asn Asn Asn Gly Ala 
        355                 360                 365             


Ala Met Phe Ser Ser His His Glu Pro Arg Gly Ser Ile Ser Lys Glu 
    370                 375                 380                 


Cys Asn Leu Val Tyr Leu Ile Pro His Ala Val Gly Ser Ser Glu Asp 
385                 390                 395                 400 


Leu Lys Lys Glu Glu Ala Ala Gly Ile Ala Arg Pro Leu Glu Lys Leu 
                405                 410                 415     


Ser Pro Ala Leu Ser Val Ile Leu Asp Tyr Asp Thr Asp Val Ser Leu 
            420                 425                 430         


Glu Lys Ile Gln Pro Ile Thr Gln Asn Gly Gln His Pro Thr 
        435                 440                 445     


<210>  3261
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRD2__Homo_sapiens__NP_000786

<400>  3261

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Gly Asn Cys Thr His Pro Glu Asp Met Lys Leu Cys Thr Val Ile 
                245                 250                 255     


Met Lys Ser Asn Gly Ser Phe Pro Val Asn Arg Arg Arg Val Glu Ala 
            260                 265                 270         


Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser 
        275                 280                 285             


Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln 
    290                 295                 300                 


Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser Thr Pro Asp 
305                 310                 315                 320 


Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp His Pro Lys 
                325                 330                 335     


Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg 
            340                 345                 350         


Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu 
        355                 360                 365             


Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile 
    370                 375                 380                 


Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile His Cys Asp 
385                 390                 395                 400 


Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr 
                405                 410                 415     


Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu 
            420                 425                 430         


Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
        435                 440             


<210>  3262
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRD3__Homo_sapiens__NP_001269492

<400>  3262

Met Ala Ser Leu Ser Gln Leu Ser Gly His Leu Asn Tyr Thr Cys Gly 
1               5                   10                  15      


Ala Glu Asn Ser Thr Gly Ala Ser Gln Ala Arg Pro His Ala Tyr Tyr 
            20                  25                  30          


Ala Leu Ser Tyr Cys Ala Leu Ile Leu Ala Ile Val Phe Gly Asn Gly 
        35                  40                  45              


Leu Val Cys Met Ala Val Leu Lys Glu Arg Ala Leu Gln Thr Thr Thr 
    50                  55                  60                  


Asn Tyr Leu Val Val Ser Leu Ala Val Ala Asp Leu Leu Val Ala Thr 
65                  70                  75                  80  


Leu Val Met Pro Trp Val Val Tyr Leu Glu Val Thr Gly Gly Val Trp 
                85                  90                  95      


Asn Phe Ser Arg Ile Cys Cys Asp Val Phe Val Thr Leu Asp Val Met 
            100                 105                 110         


Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Ile Asp Arg 
        115                 120                 125             


Tyr Thr Ala Val Val Met Pro Val His Tyr Gln His Gly Thr Gly Gln 
    130                 135                 140                 


Ser Ser Cys Arg Arg Val Ala Leu Met Ile Thr Ala Val Trp Val Leu 
145                 150                 155                 160 


Ala Phe Ala Val Ser Cys Pro Leu Leu Phe Gly Phe Asn Thr Thr Gly 
                165                 170                 175     


Asp Pro Thr Val Cys Ser Ile Ser Asn Pro Asp Phe Val Ile Tyr Ser 
            180                 185                 190         


Ser Val Val Ser Phe Tyr Leu Pro Phe Gly Val Thr Val Leu Val Tyr 
        195                 200                 205             


Ala Arg Ile Tyr Val Val Leu Lys Gln Arg Arg Arg Lys Arg Ile Leu 
    210                 215                 220                 


Thr Arg Gln Asn Ser Gln Cys Asn Ser Val Arg Pro Gly Phe Pro Gln 
225                 230                 235                 240 


Gln Thr Leu Ser Pro Asp Pro Ala His Leu Glu Leu Lys Arg Tyr Tyr 
                245                 250                 255     


Ser Ile Cys Gln Asp Thr Ala Leu Gly Gly Pro Gly Phe Gln Glu Arg 
            260                 265                 270         


Gly Gly Glu Leu Lys Arg Glu Glu Lys Thr Arg Asn Ser Leu Ser Pro 
        275                 280                 285             


Thr Ile Ala Pro Lys Leu Ser Leu Glu Val Arg Lys Leu Ser Asn Gly 
    290                 295                 300                 


Arg Leu Ser Thr Ser Leu Lys Leu Gly Pro Leu Gln Pro Arg Gly Val 
305                 310                 315                 320 


Pro Leu Arg Glu Lys Lys Ala Thr Gln Met Val Ala Ile Val Leu Gly 
                325                 330                 335     


Ala Phe Ile Val Cys Trp Leu Pro Phe Phe Leu Thr His Val Leu Asn 
            340                 345                 350         


Thr His Cys Gln Thr Cys His Val Ser Pro Glu Leu Tyr Ser Ala Thr 
        355                 360                 365             


Thr Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr Thr 
    370                 375                 380                 


Thr Phe Asn Ile Glu Phe Arg Lys Ala Phe Leu Lys Ile Leu Ser Cys 
385                 390                 395                 400 


<210>  3263
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRD4__Homo_sapiens__NP_000788

<400>  3263

Met Gly Asn Arg Ser Thr Ala Asp Ala Asp Gly Leu Leu Ala Gly Arg 
1               5                   10                  15      


Gly Pro Ala Ala Gly Ala Ser Ala Gly Ala Ser Ala Gly Leu Ala Gly 
            20                  25                  30          


Gln Gly Ala Ala Ala Leu Val Gly Gly Val Leu Leu Ile Gly Ala Val 
        35                  40                  45              


Leu Ala Gly Asn Ser Leu Val Cys Val Ser Val Ala Thr Glu Arg Ala 
    50                  55                  60                  


Leu Gln Thr Pro Thr Asn Ser Phe Ile Val Ser Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Leu Leu Leu Ala Leu Leu Val Leu Pro Leu Phe Val Tyr Ser Glu Val 
                85                  90                  95      


Gln Gly Gly Ala Trp Leu Leu Ser Pro Arg Leu Cys Asp Ala Leu Met 
            100                 105                 110         


Ala Met Asp Val Met Leu Cys Thr Ala Ser Ile Phe Asn Leu Cys Ala 
        115                 120                 125             


Ile Ser Val Asp Arg Phe Val Ala Val Ala Val Pro Leu Arg Tyr Asn 
    130                 135                 140                 


Arg Gln Gly Gly Ser Arg Arg Gln Leu Leu Leu Ile Gly Ala Thr Trp 
145                 150                 155                 160 


Leu Leu Ser Ala Ala Val Ala Ala Pro Val Leu Cys Gly Leu Asn Asp 
                165                 170                 175     


Val Arg Gly Arg Asp Pro Ala Val Cys Arg Leu Glu Asp Arg Asp Tyr 
            180                 185                 190         


Val Val Tyr Ser Ser Val Cys Ser Phe Phe Leu Pro Cys Pro Leu Met 
        195                 200                 205             


Leu Leu Leu Tyr Trp Ala Thr Phe Arg Gly Leu Gln Arg Trp Glu Val 
    210                 215                 220                 


Ala Arg Arg Ala Lys Leu His Gly Arg Ala Pro Arg Arg Pro Ser Gly 
225                 230                 235                 240 


Pro Gly Pro Pro Ser Pro Thr Pro Pro Ala Pro Arg Leu Pro Gln Asp 
                245                 250                 255     


Pro Cys Gly Pro Asp Cys Ala Pro Pro Ala Pro Gly Leu Pro Arg Gly 
            260                 265                 270         


Pro Cys Gly Pro Asp Cys Ala Pro Ala Ala Pro Ser Leu Pro Gln Asp 
        275                 280                 285             


Pro Cys Gly Pro Asp Cys Ala Pro Pro Ala Pro Gly Leu Pro Pro Asp 
    290                 295                 300                 


Pro Cys Gly Ser Asn Cys Ala Pro Pro Asp Ala Val Arg Ala Ala Ala 
305                 310                 315                 320 


Leu Pro Pro Gln Thr Pro Pro Gln Thr Arg Arg Arg Arg Arg Ala Lys 
                325                 330                 335     


Ile Thr Gly Arg Glu Arg Lys Ala Met Arg Val Leu Pro Val Val Val 
            340                 345                 350         


Gly Ala Phe Leu Leu Cys Trp Thr Pro Phe Phe Val Val His Ile Thr 
        355                 360                 365             


Gln Ala Leu Cys Pro Ala Cys Ser Val Pro Pro Arg Leu Val Ser Ala 
    370                 375                 380                 


Val Thr Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Thr Val Phe Asn Ala Glu Phe Arg Asn Val Phe Arg Lys Ala Leu Arg 
                405                 410                 415     


Ala Cys Cys 
            


<210>  3264
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRD5__Homo_sapiens__NP_000789

<400>  3264

Met Leu Pro Pro Gly Ser Asn Gly Thr Ala Tyr Pro Gly Gln Phe Ala 
1               5                   10                  15      


Leu Tyr Gln Gln Leu Ala Gln Gly Asn Ala Val Gly Gly Ser Ala Gly 
            20                  25                  30          


Ala Pro Pro Leu Gly Pro Ser Gln Val Val Thr Ala Cys Leu Leu Thr 
        35                  40                  45              


Leu Leu Ile Ile Trp Thr Leu Leu Gly Asn Val Leu Val Cys Ala Ala 
    50                  55                  60                  


Ile Val Arg Ser Arg His Leu Arg Ala Asn Met Thr Asn Val Phe Ile 
65                  70                  75                  80  


Val Ser Leu Ala Val Ser Asp Leu Phe Val Ala Leu Leu Val Met Pro 
                85                  90                  95      


Trp Lys Ala Val Ala Glu Val Ala Gly Tyr Trp Pro Phe Gly Ala Phe 
            100                 105                 110         


Cys Asp Val Trp Val Ala Phe Asp Ile Met Cys Ser Thr Ala Ser Ile 
        115                 120                 125             


Leu Asn Leu Cys Val Ile Ser Val Asp Arg Tyr Trp Ala Ile Ser Arg 
    130                 135                 140                 


Pro Phe Arg Tyr Lys Arg Lys Met Thr Gln Arg Met Ala Leu Val Met 
145                 150                 155                 160 


Val Gly Leu Ala Trp Thr Leu Ser Ile Leu Ile Ser Phe Ile Pro Val 
                165                 170                 175     


Gln Leu Asn Trp His Arg Asp Gln Ala Ala Ser Trp Gly Gly Leu Asp 
            180                 185                 190         


Leu Pro Asn Asn Leu Ala Asn Trp Thr Pro Trp Glu Glu Asp Phe Trp 
        195                 200                 205             


Glu Pro Asp Val Asn Ala Glu Asn Cys Asp Ser Ser Leu Asn Arg Thr 
    210                 215                 220                 


Tyr Ala Ile Ser Ser Ser Leu Ile Ser Phe Tyr Ile Pro Val Ala Ile 
225                 230                 235                 240 


Met Ile Val Thr Tyr Thr Arg Ile Tyr Arg Ile Ala Gln Val Gln Ile 
                245                 250                 255     


Arg Arg Ile Ser Ser Leu Glu Arg Ala Ala Glu His Ala Gln Ser Cys 
            260                 265                 270         


Arg Ser Ser Ala Ala Cys Ala Pro Asp Thr Ser Leu Arg Ala Ser Ile 
        275                 280                 285             


Lys Lys Glu Thr Lys Val Leu Lys Thr Leu Ser Val Ile Met Gly Val 
    290                 295                 300                 


Phe Val Cys Cys Trp Leu Pro Phe Phe Ile Leu Asn Cys Met Val Pro 
305                 310                 315                 320 


Phe Cys Ser Gly His Pro Glu Gly Pro Pro Ala Gly Phe Pro Cys Val 
                325                 330                 335     


Ser Glu Thr Thr Phe Asp Val Phe Val Trp Phe Gly Trp Ala Asn Ser 
            340                 345                 350         


Ser Leu Asn Pro Val Ile Tyr Ala Phe Asn Ala Asp Phe Gln Lys Val 
        355                 360                 365             


Phe Ala Gln Leu Leu Gly Cys Ser His Phe Cys Ser Arg Thr Pro Val 
    370                 375                 380                 


Glu Thr Val Asn Ile Ser Asn Glu Leu Ile Ser Tyr Asn Gln Asp Ile 
385                 390                 395                 400 


Val Phe His Lys Glu Ile Ala Ala Ala Tyr Ile His Met Met Pro Asn 
                405                 410                 415     


Ala Val Thr Pro Gly Asn Arg Glu Val Asp Asn Asp Glu Glu Glu Gly 
            420                 425                 430         


Pro Phe Asp Arg Met Phe Gln Ile Tyr Gln Thr Ser Pro Asp Gly Asp 
        435                 440                 445             


Pro Val Ala Glu Ser Val Trp Glu Leu Asp Cys Glu Gly Glu Ile Ser 
    450                 455                 460                 


Leu Asp Lys Ile Thr Pro Phe Thr Pro Asn Gly Phe His 
465                 470                 475         


<210>  3265
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRG1__Homo_sapiens__NP_004138

<400>  3265

Met Ser Ser Thr Leu Ala Lys Ile Ala Glu Ile Glu Ala Glu Met Ala 
1               5                   10                  15      


Arg Thr Gln Lys Asn Lys Ala Thr Ala His His Leu Gly Leu Leu Lys 
            20                  25                  30          


Ala Arg Leu Ala Lys Leu Arg Arg Glu Leu Ile Thr Pro Lys Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Pro Gly Glu Gly Phe Asp Val Ala Lys Thr Gly Asp 
    50                  55                  60                  


Ala Arg Ile Gly Phe Val Gly Phe Pro Ser Val Gly Lys Ser Thr Leu 
65                  70                  75                  80  


Leu Ser Asn Leu Ala Gly Val Tyr Ser Glu Val Ala Ala Tyr Glu Phe 
                85                  90                  95      


Thr Thr Leu Thr Thr Val Pro Gly Val Ile Arg Tyr Lys Gly Ala Lys 
            100                 105                 110         


Ile Gln Leu Leu Asp Leu Pro Gly Ile Ile Glu Gly Ala Lys Asp Gly 
        115                 120                 125             


Lys Gly Arg Gly Arg Gln Val Ile Ala Val Ala Arg Thr Cys Asn Leu 
    130                 135                 140                 


Ile Leu Ile Val Leu Asp Val Leu Lys Pro Leu Gly His Lys Lys Ile 
145                 150                 155                 160 


Ile Glu Asn Glu Leu Glu Gly Phe Gly Ile Arg Leu Asn Ser Lys Pro 
                165                 170                 175     


Pro Asn Ile Gly Phe Lys Lys Lys Asp Lys Gly Gly Ile Asn Leu Thr 
            180                 185                 190         


Ala Thr Cys Pro Gln Ser Glu Leu Asp Ala Glu Thr Val Lys Ser Ile 
        195                 200                 205             


Leu Ala Glu Tyr Lys Ile His Asn Ala Asp Val Thr Leu Arg Ser Asp 
    210                 215                 220                 


Ala Thr Ala Asp Asp Leu Ile Asp Val Val Glu Gly Asn Arg Val Tyr 
225                 230                 235                 240 


Ile Pro Cys Ile Tyr Val Leu Asn Lys Ile Asp Gln Ile Ser Ile Glu 
                245                 250                 255     


Glu Leu Asp Ile Ile Tyr Lys Val Pro His Cys Val Pro Ile Ser Ala 
            260                 265                 270         


His His Arg Trp Asn Phe Asp Asp Leu Leu Glu Lys Ile Trp Asp Tyr 
        275                 280                 285             


Leu Lys Leu Val Arg Ile Tyr Thr Lys Pro Lys Gly Gln Leu Pro Asp 
    290                 295                 300                 


Tyr Thr Ser Pro Val Val Leu Pro Tyr Ser Arg Thr Thr Val Glu Asp 
305                 310                 315                 320 


Phe Cys Met Lys Ile His Lys Asn Leu Ile Lys Glu Phe Lys Tyr Ala 
                325                 330                 335     


Leu Val Trp Gly Leu Ser Val Lys His Asn Pro Gln Lys Val Gly Lys 
            340                 345                 350         


Asp His Thr Leu Glu Asp Glu Asp Val Ile Gln Ile Val Lys Lys 
        355                 360                 365         


<210>  3266
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRGX__Homo_sapiens__NP_001263380

<400>  3266

Met Phe Tyr Phe His Cys Pro Pro Gln Leu Glu Gly Thr Ala Thr Phe 
1               5                   10                  15      


Gly Asn His Ser Ser Gly Asp Phe Asp Asp Gly Phe Leu Arg Arg Lys 
            20                  25                  30          


Gln Arg Arg Asn Arg Thr Thr Phe Thr Leu Gln Gln Leu Glu Ala Leu 
        35                  40                  45              


Glu Ala Val Phe Ala Gln Thr His Tyr Pro Asp Val Phe Thr Arg Glu 
    50                  55                  60                  


Glu Leu Ala Met Lys Ile Asn Leu Thr Glu Ala Arg Val Gln Val Trp 
65                  70                  75                  80  


Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Thr Glu Arg Gly Ala Ser 
                85                  90                  95      


Asp Gln Glu Pro Gly Ala Lys Glu Pro Met Ala Glu Val Thr Pro Pro 
            100                 105                 110         


Pro Val Arg Asn Ile Asn Ser Pro Pro Pro Gly Asp Gln Ala Arg Ser 
        115                 120                 125             


Lys Lys Glu Ala Leu Glu Ala Gln Gln Ser Leu Gly Arg Thr Val Gly 
    130                 135                 140                 


Pro Ala Gly Pro Phe Phe Pro Ser Cys Leu Pro Gly Thr Leu Leu Asn 
145                 150                 155                 160 


Thr Ala Thr Tyr Ala Gln Ala Leu Ser His Val Ala Ser Leu Lys Gly 
                165                 170                 175     


Gly Pro Leu Cys Ser Cys Cys Val Pro Asp Pro Met Gly Leu Ser Phe 
            180                 185                 190         


Leu Pro Thr Tyr Gly Cys Gln Ser Asn Arg Thr Ala Ser Val Ala Thr 
        195                 200                 205             


Leu Arg Met Lys Ala Arg Glu His Ser Glu Ala Val Leu Gln Ser Ala 
    210                 215                 220                 


Asn Leu Leu Pro Ser Thr Ser Ser Ser Pro Gly Pro Val Ala Lys Pro 
225                 230                 235                 240 


Ala Pro Pro Asp Gly Ser Gln Glu Lys Thr Ser Pro Thr Lys Glu Gln 
                245                 250                 255     


Ser Glu Ala Glu Lys Ser Val 
            260             


<210>  3267
<211>  1337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DROSHA__Homo_sapiens__NP_001093882

<400>  3267

Met Met Gln Gly Asn Thr Cys His Arg Met Ser Phe His Pro Gly Arg 
1               5                   10                  15      


Gly Cys Pro Arg Gly Arg Gly Gly His Gly Ala Arg Pro Ser Ala Pro 
            20                  25                  30          


Ser Phe Arg Pro Gln Asn Leu Arg Leu Leu His Pro Gln Gln Pro Pro 
        35                  40                  45              


Val Gln Tyr Gln Tyr Glu Pro Pro Ser Ala Pro Ser Thr Thr Phe Ser 
    50                  55                  60                  


Asn Ser Pro Ala Pro Asn Phe Leu Pro Pro Arg Pro Asp Phe Val Pro 
65                  70                  75                  80  


Phe Pro Pro Pro Met Pro Pro Ser Ala Gln Gly Pro Leu Pro Pro Cys 
                85                  90                  95      


Pro Ile Arg Pro Pro Phe Pro Asn His Gln Met Arg His Pro Phe Pro 
            100                 105                 110         


Val Pro Pro Cys Phe Pro Pro Met Pro Pro Pro Met Pro Cys Pro Asn 
        115                 120                 125             


Asn Pro Pro Val Pro Gly Ala Pro Pro Gly Gln Gly Thr Phe Pro Phe 
    130                 135                 140                 


Met Met Pro Pro Pro Ser Met Pro His Pro Pro Pro Pro Pro Val Met 
145                 150                 155                 160 


Pro Gln Gln Val Asn Tyr Gln Tyr Pro Pro Gly Tyr Ser His His Asn 
                165                 170                 175     


Phe Pro Pro Pro Ser Phe Asn Ser Phe Gln Asn Asn Pro Ser Ser Phe 
            180                 185                 190         


Leu Pro Ser Ala Asn Asn Ser Ser Ser Pro His Phe Arg His Leu Pro 
        195                 200                 205             


Pro Tyr Pro Leu Pro Lys Ala Pro Ser Glu Arg Arg Ser Pro Glu Arg 
    210                 215                 220                 


Leu Lys His Tyr Asp Asp His Arg His Arg Asp His Ser His Gly Arg 
225                 230                 235                 240 


Gly Glu Arg His Arg Ser Leu Asp Arg Arg Glu Arg Gly Arg Ser Pro 
                245                 250                 255     


Asp Arg Arg Arg Gln Asp Ser Arg Tyr Arg Ser Asp Tyr Asp Arg Gly 
            260                 265                 270         


Arg Thr Pro Ser Arg His Arg Ser Tyr Glu Arg Ser Arg Glu Arg Glu 
        275                 280                 285             


Arg Glu Arg His Arg His Arg Asp Asn Arg Arg Ser Pro Ser Leu Glu 
    290                 295                 300                 


Arg Ser Tyr Lys Lys Glu Tyr Lys Arg Ser Gly Ser Arg Ser Pro Ser 
305                 310                 315                 320 


Arg Glu Lys Lys Arg Ala Arg Trp Glu Glu Glu Lys Asp Arg Trp Ser 
                325                 330                 335     


Asp Asn Gln Ser Ser Gly Lys Asp Lys Asn Tyr Thr Ser Ile Lys Glu 
            340                 345                 350         


Lys Glu Pro Glu Glu Thr Met Pro Asp Lys Asn Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Leu Leu Lys Pro Val Trp Ile Arg Cys Thr His Ser Glu Asn Tyr 
    370                 375                 380                 


Tyr Ser Ser Asp Pro Met Asp Gln Val Gly Asp Ser Thr Val Val Gly 
385                 390                 395                 400 


Thr Ser Arg Leu Arg Asp Leu Tyr Asp Lys Phe Glu Glu Glu Leu Gly 
                405                 410                 415     


Ser Arg Gln Glu Lys Ala Lys Ala Ala Arg Pro Pro Trp Glu Pro Pro 
            420                 425                 430         


Lys Thr Lys Leu Asp Glu Asp Leu Glu Ser Ser Ser Glu Ser Glu Cys 
        435                 440                 445             


Glu Ser Asp Glu Asp Ser Thr Cys Ser Ser Ser Ser Asp Ser Glu Val 
    450                 455                 460                 


Phe Asp Val Ile Ala Glu Ile Lys Arg Lys Lys Ala His Pro Asp Arg 
465                 470                 475                 480 


Leu His Asp Glu Leu Trp Tyr Asn Asp Pro Gly Gln Met Asn Asp Gly 
                485                 490                 495     


Pro Leu Cys Lys Cys Ser Ala Lys Ala Arg Arg Thr Gly Ile Arg His 
            500                 505                 510         


Ser Ile Tyr Pro Gly Glu Glu Ala Ile Lys Pro Cys Arg Pro Met Thr 
        515                 520                 525             


Asn Asn Ala Gly Arg Leu Phe His Tyr Arg Ile Thr Val Ser Pro Pro 
    530                 535                 540                 


Thr Asn Phe Leu Thr Asp Arg Pro Thr Val Ile Glu Tyr Asp Asp His 
545                 550                 555                 560 


Glu Tyr Ile Phe Glu Gly Phe Ser Met Phe Ala His Ala Pro Leu Thr 
                565                 570                 575     


Asn Ile Pro Leu Cys Lys Val Ile Arg Phe Asn Ile Asp Tyr Thr Ile 
            580                 585                 590         


His Phe Ile Glu Glu Met Met Pro Glu Asn Phe Cys Val Lys Gly Leu 
        595                 600                 605             


Glu Leu Phe Ser Leu Phe Leu Phe Arg Asp Ile Leu Glu Leu Tyr Asp 
    610                 615                 620                 


Trp Asn Leu Lys Gly Pro Leu Phe Glu Asp Ser Pro Pro Cys Cys Pro 
625                 630                 635                 640 


Arg Phe His Phe Met Pro Arg Phe Val Arg Phe Leu Pro Asp Gly Gly 
                645                 650                 655     


Lys Glu Val Leu Ser Met His Gln Ile Leu Leu Tyr Leu Leu Arg Cys 
            660                 665                 670         


Ser Lys Ala Leu Val Pro Glu Glu Glu Ile Ala Asn Met Leu Gln Trp 
        675                 680                 685             


Glu Glu Leu Glu Trp Gln Lys Tyr Ala Glu Glu Cys Lys Gly Met Ile 
    690                 695                 700                 


Val Thr Asn Pro Gly Thr Lys Pro Ser Ser Val Arg Ile Asp Gln Leu 
705                 710                 715                 720 


Asp Arg Glu Gln Phe Asn Pro Asp Val Ile Thr Phe Pro Ile Ile Val 
                725                 730                 735     


His Phe Gly Ile Arg Pro Ala Gln Leu Ser Tyr Ala Gly Asp Pro Gln 
            740                 745                 750         


Tyr Gln Lys Leu Trp Lys Ser Tyr Val Lys Leu Arg His Leu Leu Ala 
        755                 760                 765             


Asn Ser Pro Lys Val Lys Gln Thr Asp Lys Gln Lys Leu Ala Gln Arg 
    770                 775                 780                 


Glu Glu Ala Leu Gln Lys Ile Arg Gln Lys Asn Thr Met Arg Arg Glu 
785                 790                 795                 800 


Val Thr Val Glu Leu Ser Ser Gln Gly Phe Trp Lys Thr Gly Ile Arg 
                805                 810                 815     


Ser Asp Val Cys Gln His Ala Met Met Leu Pro Val Leu Thr His His 
            820                 825                 830         


Ile Arg Tyr His Gln Cys Leu Met His Leu Asp Lys Leu Ile Gly Tyr 
        835                 840                 845             


Thr Phe Gln Asp Arg Cys Leu Leu Gln Leu Ala Met Thr His Pro Ser 
    850                 855                 860                 


His His Leu Asn Phe Gly Met Asn Pro Asp His Ala Arg Asn Ser Leu 
865                 870                 875                 880 


Ser Asn Cys Gly Ile Arg Gln Pro Lys Tyr Gly Asp Arg Lys Val His 
                885                 890                 895     


His Met His Met Arg Lys Lys Gly Ile Asn Thr Leu Ile Asn Ile Met 
            900                 905                 910         


Ser Arg Leu Gly Gln Asp Asp Pro Thr Pro Ser Arg Ile Asn His Asn 
        915                 920                 925             


Glu Arg Leu Glu Phe Leu Gly Asp Ala Val Val Glu Phe Leu Thr Ser 
    930                 935                 940                 


Val His Leu Tyr Tyr Leu Phe Pro Ser Leu Glu Glu Gly Gly Leu Ala 
945                 950                 955                 960 


Thr Tyr Arg Thr Ala Ile Val Gln Asn Gln His Leu Ala Met Leu Ala 
                965                 970                 975     


Lys Lys Leu Glu Leu Asp Arg Phe Met Leu Tyr Ala His Gly Pro Asp 
            980                 985                 990         


Leu Cys Arg Glu Ser Asp Leu Arg  His Ala Met Ala Asn  Cys Phe Glu 
        995                 1000                 1005             


Ala Leu  Ile Gly Ala Val Tyr  Leu Glu Gly Ser Leu  Glu Glu Ala 
    1010                 1015                 1020             


Lys Gln  Leu Phe Gly Arg Leu  Leu Phe Asn Asp Pro  Asp Leu Arg 
    1025                 1030                 1035             


Glu Val  Trp Leu Asn Tyr Pro  Leu His Pro Leu Gln  Leu Gln Glu 
    1040                 1045                 1050             


Pro Asn  Thr Asp Arg Gln Leu  Ile Glu Thr Ser Pro  Val Leu Gln 
    1055                 1060                 1065             


Lys Leu  Thr Glu Phe Glu Glu  Ala Ile Gly Val Ile  Phe Thr His 
    1070                 1075                 1080             


Val Arg  Leu Leu Ala Arg Ala  Phe Thr Leu Arg Thr  Val Gly Phe 
    1085                 1090                 1095             


Asn His  Leu Thr Leu Gly His  Asn Gln Arg Met Glu  Phe Leu Gly 
    1100                 1105                 1110             


Asp Ser  Ile Met Gln Leu Val  Ala Thr Glu Tyr Leu  Phe Ile His 
    1115                 1120                 1125             


Phe Pro  Asp His His Glu Gly  His Leu Thr Leu Leu  Arg Ser Ser 
    1130                 1135                 1140             


Leu Val  Asn Asn Arg Thr Gln  Ala Lys Val Ala Glu  Glu Leu Gly 
    1145                 1150                 1155             


Met Gln  Glu Tyr Ala Ile Thr  Asn Asp Lys Thr Lys  Arg Pro Val 
    1160                 1165                 1170             


Ala Leu  Arg Thr Lys Thr Leu  Ala Asp Leu Leu Glu  Ser Phe Ile 
    1175                 1180                 1185             


Ala Ala  Leu Tyr Ile Asp Lys  Asp Leu Glu Tyr Val  His Thr Phe 
    1190                 1195                 1200             


Met Asn  Val Cys Phe Phe Pro  Arg Leu Lys Glu Phe  Ile Leu Asn 
    1205                 1210                 1215             


Gln Asp  Trp Asn Asp Pro Lys  Ser Gln Leu Gln Gln  Cys Cys Leu 
    1220                 1225                 1230             


Thr Leu  Arg Thr Glu Gly Lys  Glu Pro Asp Ile Pro  Leu Tyr Lys 
    1235                 1240                 1245             


Thr Leu  Gln Thr Val Gly Pro  Ser His Ala Arg Thr  Tyr Thr Val 
    1250                 1255                 1260             


Ala Val  Tyr Phe Lys Gly Glu  Arg Ile Gly Cys Gly  Lys Gly Pro 
    1265                 1270                 1275             


Ser Ile  Gln Gln Ala Glu Met  Gly Ala Ala Met Asp  Ala Leu Glu 
    1280                 1285                 1290             


Lys Tyr  Asn Phe Pro Gln Met  Ala His Gln Lys Arg  Phe Ile Glu 
    1295                 1300                 1305             


Arg Lys  Tyr Arg Gln Glu Leu  Lys Glu Met Arg Trp  Glu Arg Glu 
    1310                 1315                 1320             


His Gln  Glu Arg Glu Pro Asp  Glu Thr Glu Asp Ile  Lys Lys 
    1325                 1330                 1335         


<210>  3268
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRP2__Homo_sapiens__NP_001164655

<400>  3268

Met Asn Leu Cys Trp Asn Glu Ile Lys Lys Lys Ser His Asn Leu Arg 
1               5                   10                  15      


Ala Arg Leu Glu Ala Phe Ser Asp His Ser Gly Lys Leu Gln Leu Pro 
            20                  25                  30          


Leu Gln Glu Ile Ile Asp Trp Leu Ser Gln Lys Asp Glu Glu Leu Ser 
        35                  40                  45              


Ala Gln Leu Pro Leu Gln Gly Asp Val Ala Leu Val Gln Gln Glu Lys 
    50                  55                  60                  


Glu Thr His Ala Ala Phe Met Glu Glu Val Lys Ser Arg Gly Pro Tyr 
65                  70                  75                  80  


Ile Tyr Ser Val Leu Glu Ser Ala Gln Ala Phe Leu Ser Gln His Pro 
                85                  90                  95      


Phe Glu Glu Leu Glu Glu Pro His Ser Glu Ser Lys Asp Thr Ser Pro 
            100                 105                 110         


Lys Gln Arg Ile Gln Asn Leu Ser Arg Phe Val Trp Lys Gln Ala Thr 
        115                 120                 125             


Val Ala Ser Glu Leu Trp Glu Lys Leu Thr Ala Arg Cys Val Asp Gln 
    130                 135                 140                 


His Arg His Ile Glu Arg Thr Leu Glu Gln Leu Leu Glu Ile Gln Gly 
145                 150                 155                 160 


Ala Met Glu Glu Leu Ser Thr Thr Leu Ser Gln Ala Glu Gly Val Arg 
                165                 170                 175     


Ala Thr Trp Glu Pro Ile Gly Asp Leu Phe Ile Asp Ser Leu Pro Glu 
            180                 185                 190         


His Ile Gln Ala Ile Lys Leu Phe Lys Glu Glu Phe Ser Pro Met Lys 
        195                 200                 205             


Asp Gly Val Lys Leu Val Asn Asp Leu Ala His Gln Leu Ala Ile Ser 
    210                 215                 220                 


Asp Val His Leu Ser Met Glu Asn Ser Gln Ala Leu Glu Gln Ile Asn 
225                 230                 235                 240 


Val Arg Trp Lys Gln Leu Gln Ala Ser Val Ser Glu Arg Leu Lys Gln 
                245                 250                 255     


Leu Gln Asp Ala His Arg Asp Phe Gly Pro Gly Ser Gln His Phe Leu 
            260                 265                 270         


Ser Ser Ser Val Gln Val Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys 
        275                 280                 285             


Val Pro Tyr Tyr Ile Asn His Gln Ala Gln Thr Thr Cys Trp Asp His 
    290                 295                 300                 


Pro Lys Met Thr Glu Leu Tyr Gln Thr Leu Ala Asp Leu Asn Asn Ile 
305                 310                 315                 320 


Lys Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Val Gln Lys 
                325                 330                 335     


Ala Leu Arg Leu Asp Leu Val Thr Leu Thr Thr Ala Leu Glu Ile Phe 
            340                 345                 350         


Asn Glu His Asp Leu Gln Ala Ser Glu His Val Met Asp Val Val Glu 
        355                 360                 365             


Val Ile His Cys Leu Thr Ala Leu Tyr Glu Arg Leu Glu Glu Glu Arg 
    370                 375                 380                 


Gly Ile Leu Val Asn Val Pro Leu Cys Val Asp Met Ser Leu Asn Trp 
385                 390                 395                 400 


Leu Leu Asn Val Phe Asp Ser Gly Arg Ser Gly Lys Met Arg Ala Leu 
                405                 410                 415     


Ser Phe Lys Thr Gly Ile Ala Cys Leu Cys Gly Thr Glu Val Lys Glu 
            420                 425                 430         


Lys Leu Gln Tyr Leu Phe Ser Gln Val Ala Asn Ser Gly Ser Gln Cys 
        435                 440                 445             


Asp Gln Arg His Leu Gly Val Leu Leu His Glu Ala Ile Gln Val Pro 
    450                 455                 460                 


Arg Gln Leu Gly Glu Val Ala Ala Phe Gly Gly Ser Asn Val Glu Pro 
465                 470                 475                 480 


Ser Val Arg Ser Cys Phe Arg Phe Ser Thr Gly Lys Pro Val Ile Glu 
                485                 490                 495     


Ala Ser Gln Phe Leu Glu Trp Val Asn Leu Glu Pro Gln Ser Met Val 
            500                 505                 510         


Trp Leu Ala Val Leu His Arg Val Thr Ile Ala Glu Gln Val Lys His 
        515                 520                 525             


Gln Thr Lys Cys Ser Ile Cys Arg Gln Cys Pro Ile Lys Gly Phe Arg 
    530                 535                 540                 


Tyr Arg Ser Leu Lys Gln Phe Asn Val Asp Ile Cys Gln Thr Cys Phe 
545                 550                 555                 560 


Leu Thr Gly Arg Ala Ser Lys Gly Asn Lys Leu His Tyr Pro Ile Met 
                565                 570                 575     


Glu Tyr Tyr Thr Pro Thr Thr Ser Ser Glu Asn Met Arg Asp Phe Ala 
            580                 585                 590         


Thr Thr Leu Lys Asn Lys Phe Arg Ser Lys His Tyr Phe Ser Lys His 
        595                 600                 605             


Pro Gln Arg Gly Tyr Leu Pro Val Gln Ser Val Leu Glu Ala Asp Tyr 
    610                 615                 620                 


Ser Glu Thr Pro Ala Ser Ser Pro Met Trp Pro His Ala Asp Thr His 
625                 630                 635                 640 


Ser Arg Ile Glu His Phe Ala Ser Arg Leu Ala Glu Met Glu Ser Gln 
                645                 650                 655     


Asn Cys Ser Phe Phe Asn Asp Ser Leu Ser Pro Asp Asp Ser Ile Asp 
            660                 665                 670         


Glu Asp Gln Tyr Leu Leu Arg His Ser Ser Pro Ile Thr Asp Arg Glu 
        675                 680                 685             


Pro Ala Phe Gly Gln Gln Ala Pro Cys Ser Val Ala Thr Glu Ser Lys 
    690                 695                 700                 


Gly Glu Leu Gln Lys Ile Leu Ala His Leu Glu Asp Glu Asn Arg Ile 
705                 710                 715                 720 


Leu Gln Gly Glu Leu Arg Arg Leu Lys Trp Gln His Glu Glu Ala Ala 
                725                 730                 735     


Glu Ala Pro Ser Leu Ala Asp Gly Ser Thr Glu Ala Ala Thr Asp His 
            740                 745                 750         


Arg Asn Glu Glu Leu Leu Ala Glu Ala Arg Ile Leu Arg Gln His Lys 
        755                 760                 765             


Ser Arg Leu Glu Thr Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln 
    770                 775                 780                 


Leu Glu Ser Gln Leu Gln Arg Leu Arg Glu Leu Leu Leu Gln Pro Pro 
785                 790                 795                 800 


Thr Glu Ser Asp Gly Ser Gly Ser Ala Gly Ser Ser Leu Ala Ser Ser 
                805                 810                 815     


Pro Gln Gln Ser Glu Gly Ser His Pro Arg Glu Lys Gly Gln Thr Thr 
            820                 825                 830         


Pro Asp Thr Glu Ala Ala Asp Asp Val Gly Ser Lys Ser Gln Asp Val 
        835                 840                 845             


Ser Leu Cys Leu Glu Asp Ile Met Glu Lys Leu Arg His Ala Phe Pro 
    850                 855                 860                 


Ser Val Arg Ser Ser Asp Val Thr Ala Asn Thr Leu Leu Ala Ser 
865                 870                 875                 


<210>  3269
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSC1__Homo_sapiens__NP_004939

<400>  3269

Met Ala Leu Ala Ser Ala Ala Pro Gly Ser Ile Phe Cys Lys Gln Leu 
1               5                   10                  15      


Leu Phe Ser Leu Leu Val Leu Thr Leu Leu Cys Asp Ala Cys Gln Lys 
            20                  25                  30          


Val Tyr Leu Arg Val Pro Ser His Leu Gln Ala Glu Thr Leu Val Gly 
        35                  40                  45              


Lys Val Asn Leu Glu Glu Cys Leu Lys Ser Ala Ser Leu Ile Arg Ser 
    50                  55                  60                  


Ser Asp Pro Ala Phe Arg Ile Leu Glu Asp Gly Ser Ile Tyr Thr Thr 
65                  70                  75                  80  


His Asp Leu Ile Leu Ser Ser Glu Arg Lys Ser Phe Ser Ile Phe Leu 
                85                  90                  95      


Ser Asp Gly Gln Arg Arg Glu Gln Gln Glu Ile Lys Val Val Leu Ser 
            100                 105                 110         


Ala Arg Glu Asn Lys Ser Pro Lys Lys Arg His Thr Lys Asp Thr Ala 
        115                 120                 125             


Leu Lys Arg Ser Lys Arg Arg Trp Ala Pro Ile Pro Ala Ser Leu Met 
    130                 135                 140                 


Glu Asn Ser Leu Gly Pro Phe Pro Gln His Val Gln Gln Ile Gln Ser 
145                 150                 155                 160 


Asp Ala Ala Gln Asn Tyr Thr Ile Phe Tyr Ser Ile Ser Gly Pro Gly 
                165                 170                 175     


Val Asp Lys Glu Pro Phe Asn Leu Phe Tyr Ile Glu Lys Asp Thr Gly 
            180                 185                 190         


Asp Ile Phe Cys Thr Arg Ser Ile Asp Arg Glu Lys Tyr Glu Gln Phe 
        195                 200                 205             


Ala Leu Tyr Gly Tyr Ala Thr Thr Ala Asp Gly Tyr Ala Pro Glu Tyr 
    210                 215                 220                 


Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Asp Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Tyr Phe Glu His Arg Val Thr Ile Phe Thr Val Pro Glu Asn Cys Arg 
                245                 250                 255     


Ser Gly Thr Ser Val Gly Lys Val Thr Ala Thr Asp Leu Asp Glu Pro 
            260                 265                 270         


Asp Thr Leu His Thr Arg Leu Lys Tyr Lys Ile Leu Gln Gln Ile Pro 
        275                 280                 285             


Asp His Pro Lys His Phe Ser Ile His Pro Asp Thr Gly Val Ile Thr 
    290                 295                 300                 


Thr Thr Thr Pro Phe Leu Asp Arg Glu Lys Cys Asp Thr Tyr Gln Leu 
305                 310                 315                 320 


Ile Met Glu Val Arg Asp Met Gly Gly Gln Pro Phe Gly Leu Phe Asn 
                325                 330                 335     


Thr Gly Thr Ile Thr Ile Ser Leu Glu Asp Glu Asn Asp Asn Pro Pro 
            340                 345                 350         


Ser Phe Thr Glu Thr Ser Tyr Val Thr Glu Val Glu Glu Asn Arg Ile 
        355                 360                 365             


Asp Val Glu Ile Leu Arg Met Lys Val Gln Asp Gln Asp Leu Pro Asn 
    370                 375                 380                 


Thr Pro His Ser Lys Ala Val Tyr Lys Ile Leu Gln Gly Asn Glu Asn 
385                 390                 395                 400 


Gly Asn Phe Ile Ile Ser Thr Asp Pro Asn Thr Asn Glu Gly Val Leu 
                405                 410                 415     


Cys Val Val Lys Pro Leu Asn Tyr Glu Val Asn Arg Gln Val Ile Leu 
            420                 425                 430         


Gln Val Gly Val Ile Asn Glu Ala Gln Phe Ser Lys Ala Ala Ser Ser 
        435                 440                 445             


Gln Thr Pro Thr Met Cys Thr Thr Thr Val Thr Val Lys Ile Ile Asp 
    450                 455                 460                 


Ser Asp Glu Gly Pro Glu Cys His Pro Pro Val Lys Val Ile Gln Ser 
465                 470                 475                 480 


Gln Asp Gly Phe Pro Ala Gly Gln Glu Leu Leu Gly Tyr Lys Ala Leu 
                485                 490                 495     


Asp Pro Glu Ile Ser Ser Gly Glu Gly Leu Arg Tyr Gln Lys Leu Gly 
            500                 505                 510         


Asp Glu Asp Asn Trp Phe Glu Ile Asn Gln His Thr Gly Asp Leu Arg 
        515                 520                 525             


Thr Leu Lys Val Leu Asp Arg Glu Ser Lys Phe Val Lys Asn Asn Gln 
    530                 535                 540                 


Tyr Asn Ile Ser Val Val Ala Val Asp Ala Val Gly Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Val Val His Leu Asp Asp Tyr Asn Asp His Ala Pro Gln 
                565                 570                 575     


Ile Asp Lys Glu Val Thr Ile Cys Gln Asn Asn Glu Asp Phe Ala Val 
            580                 585                 590         


Leu Lys Pro Val Asp Pro Asp Gly Pro Glu Asn Gly Pro Pro Phe Gln 
        595                 600                 605             


Phe Phe Leu Asp Asn Ser Ala Ser Lys Asn Trp Asn Ile Glu Glu Lys 
    610                 615                 620                 


Asp Gly Lys Thr Ala Ile Leu Arg Gln Arg Gln Asn Leu Asp Tyr Asn 
625                 630                 635                 640 


Tyr Tyr Ser Val Pro Ile Gln Ile Lys Asp Arg His Gly Leu Val Ala 
                645                 650                 655     


Thr His Met Leu Thr Val Arg Val Cys Asp Cys Ser Thr Pro Ser Glu 
            660                 665                 670         


Cys Arg Met Lys Asp Lys Ser Thr Arg Asp Val Arg Pro Asn Val Ile 
        675                 680                 685             


Leu Gly Arg Trp Ala Ile Leu Ala Met Val Leu Gly Ser Val Leu Leu 
    690                 695                 700                 


Leu Cys Ile Leu Phe Thr Cys Phe Cys Val Thr Ala Lys Arg Thr Val 
705                 710                 715                 720 


Lys Lys Cys Phe Pro Glu Asp Ile Ala Gln Gln Asn Leu Ile Val Ser 
                725                 730                 735     


Asn Thr Glu Gly Pro Gly Glu Glu Val Thr Glu Ala Asn Ile Arg Leu 
            740                 745                 750         


Pro Met Gln Thr Ser Asn Ile Cys Asp Thr Ser Met Ser Val Gly Thr 
        755                 760                 765             


Val Gly Gly Gln Gly Ile Lys Thr Gln Gln Ser Phe Glu Met Val Lys 
    770                 775                 780                 


Gly Gly Tyr Thr Leu Asp Ser Asn Lys Gly Gly Gly His Gln Thr Leu 
785                 790                 795                 800 


Glu Ser Val Lys Gly Val Gly Gln Gly Asp Thr Gly Arg Tyr Ala Tyr 
                805                 810                 815     


Thr Asp Trp Gln Ser Phe Thr Gln Pro Arg Leu Gly Glu Glu Ser Ile 
            820                 825                 830         


Arg Gly His Thr Leu Ile Lys Asn 
        835                 840 


<210>  3270
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSC2__Homo_sapiens__NP_004940

<400>  3270

Met Glu Ala Ala Arg Pro Ser Gly Ser Trp Asn Gly Ala Leu Cys Arg 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Ala Ile Leu Ile Phe Ala Ser Asp Ala Cys 
            20                  25                  30          


Lys Asn Val Thr Leu His Val Pro Ser Lys Leu Asp Ala Glu Lys Leu 
        35                  40                  45              


Val Gly Arg Val Asn Leu Lys Glu Cys Phe Thr Ala Ala Asn Leu Ile 
    50                  55                  60                  


His Ser Ser Asp Pro Asp Phe Gln Ile Leu Glu Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Thr Asn Thr Ile Leu Leu Ser Ser Glu Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Leu Leu Ser Asn Thr Glu Asn Gln Glu Lys Lys Lys Ile Phe Val Phe 
            100                 105                 110         


Leu Glu His Gln Thr Lys Val Leu Lys Lys Arg His Thr Lys Glu Lys 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Leu Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Gln 
145                 150                 155                 160 


Ser Asp Thr Ala Gln Asn Tyr Thr Ile Tyr Tyr Ser Ile Arg Gly Pro 
                165                 170                 175     


Gly Val Asp Gln Glu Pro Arg Asn Leu Phe Tyr Val Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Tyr Cys Thr Arg Pro Val Asp Arg Glu Gln Tyr Glu Ser 
        195                 200                 205             


Phe Glu Ile Ile Ala Phe Ala Thr Thr Pro Asp Gly Tyr Thr Pro Glu 
    210                 215                 220                 


Leu Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Glu Asn Asp Asn Tyr 
225                 230                 235                 240 


Pro Ile Phe Thr Glu Glu Thr Tyr Thr Phe Thr Ile Phe Glu Asn Cys 
                245                 250                 255     


Arg Val Gly Thr Thr Val Gly Gln Val Cys Ala Thr Asp Lys Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Ile Gly Gln Val 
        275                 280                 285             


Pro Pro Ser Pro Thr Leu Phe Ser Met His Pro Thr Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Thr Ser Ser Gln Leu Asp Arg Glu Leu Ile Asp Lys Tyr Gln 
305                 310                 315                 320 


Leu Lys Ile Lys Val Gln Asp Met Asp Gly Gln Tyr Phe Gly Leu Gln 
                325                 330                 335     


Thr Thr Ser Thr Cys Ile Ile Asn Ile Asp Asp Val Asn Asp His Leu 
            340                 345                 350         


Pro Thr Phe Thr Arg Thr Ser Tyr Val Thr Ser Val Glu Glu Asn Thr 
        355                 360                 365             


Val Asp Val Glu Ile Leu Arg Val Thr Val Glu Asp Lys Asp Leu Val 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Ala Asn Tyr Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly Asn Phe Lys Ile Val Thr Asp Ala Lys Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Cys Val Val Lys Pro Leu Asn Tyr Glu Glu Lys Gln Gln Met Ile 
            420                 425                 430         


Leu Gln Ile Gly Val Val Asn Glu Ala Pro Phe Ser Arg Glu Ala Ser 
        435                 440                 445             


Pro Arg Ser Ala Met Ser Thr Ala Thr Val Thr Val Asn Val Glu Asp 
    450                 455                 460                 


Gln Asp Glu Gly Pro Glu Cys Asn Pro Pro Ile Gln Thr Val Arg Met 
465                 470                 475                 480 


Lys Glu Asn Ala Glu Val Gly Thr Thr Ser Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Thr Arg Ser Ser Ser Gly Ile Arg Tyr Lys Lys Leu Thr 
            500                 505                 510         


Asp Pro Thr Gly Trp Val Thr Ile Asp Glu Asn Thr Gly Ser Ile Lys 
        515                 520                 525             


Val Phe Arg Ser Leu Asp Arg Glu Ala Glu Thr Ile Lys Asn Gly Ile 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ser Asp Gln Gly Gly Arg Thr Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Gly Ile Ile Leu Gln Asp Val Asn Asp Asn Ser Pro Phe 
                565                 570                 575     


Ile Pro Lys Lys Thr Val Ile Ile Cys Lys Pro Thr Met Ser Ser Ala 
            580                 585                 590         


Glu Ile Val Ala Val Asp Pro Asp Glu Pro Ile His Gly Pro Pro Phe 
        595                 600                 605             


Asp Phe Ser Leu Glu Ser Ser Thr Ser Glu Val Gln Arg Met Trp Arg 
    610                 615                 620                 


Leu Lys Ala Ile Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Asn Asp 
625                 630                 635                 640 


Pro Pro Phe Gly Ser Tyr Val Val Pro Ile Thr Val Arg Asp Arg Leu 
                645                 650                 655     


Gly Met Ser Ser Val Thr Ser Leu Asp Val Thr Leu Cys Asp Cys Ile 
            660                 665                 670         


Thr Glu Asn Asp Cys Thr His Arg Val Asp Pro Arg Ile Gly Gly Gly 
        675                 680                 685             


Gly Val Gln Leu Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile 
    690                 695                 700                 


Ala Leu Leu Phe Cys Ile Leu Phe Thr Leu Val Cys Gly Ala Ser Gly 
705                 710                 715                 720 


Thr Ser Lys Gln Pro Lys Val Ile Pro Asp Asp Leu Ala Gln Gln Asn 
                725                 730                 735     


Leu Ile Val Ser Asn Thr Glu Ala Pro Gly Asp Asp Lys Val Tyr Ser 
            740                 745                 750         


Ala Asn Gly Phe Thr Thr Gln Thr Val Gly Ala Ser Ala Gln Gly Val 
        755                 760                 765             


Cys Gly Thr Val Gly Ser Gly Ile Lys Asn Gly Gly Gln Glu Thr Ile 
    770                 775                 780                 


Glu Met Val Lys Gly Gly His Gln Thr Ser Glu Ser Cys Arg Gly Ala 
785                 790                 795                 800 


Gly His His His Thr Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val 
                805                 810                 815     


Asp Asn Cys Arg Tyr Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro 
            820                 825                 830         


Arg Leu Gly Glu Glu Ser Ile Arg Gly His Thr Leu Ile Lys Asn 
        835                 840                 845         


<210>  3271
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSC3__Homo_sapiens__NP_001932

<400>  3271

Met Ala Ala Ala Gly Pro Arg Arg Ser Val Arg Gly Ala Val Cys Leu 
1               5                   10                  15      


His Leu Leu Leu Thr Leu Val Ile Phe Ser Arg Ala Gly Glu Ala Cys 
            20                  25                  30          


Lys Lys Val Ile Leu Asn Val Pro Ser Lys Leu Glu Ala Asp Lys Ile 
        35                  40                  45              


Ile Gly Arg Val Asn Leu Glu Glu Cys Phe Arg Ser Ala Asp Leu Ile 
    50                  55                  60                  


Arg Ser Ser Asp Pro Asp Phe Arg Val Leu Asn Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Ala Arg Ala Val Ala Leu Ser Asp Lys Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Trp Leu Ser Asp Lys Arg Lys Gln Thr Gln Lys Glu Val Thr Val Leu 
            100                 105                 110         


Leu Glu His Gln Lys Lys Val Ser Lys Thr Arg His Thr Arg Glu Thr 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Gln Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Glu 
145                 150                 155                 160 


Ser Asp Ala Ala Gln Asn Tyr Thr Val Phe Tyr Ser Ile Ser Gly Arg 
                165                 170                 175     


Gly Val Asp Lys Glu Pro Leu Asn Leu Phe Tyr Ile Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Phe Cys Thr Arg Pro Val Asp Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Phe Asp Leu Ile Ala Tyr Ala Ser Thr Ala Asp Gly Tyr Ser Ala Asp 
    210                 215                 220                 


Leu Pro Leu Pro Leu Pro Ile Arg Val Glu Asp Glu Asn Asp Asn His 
225                 230                 235                 240 


Pro Val Phe Thr Glu Ala Ile Tyr Asn Phe Glu Val Leu Glu Ser Ser 
                245                 250                 255     


Arg Pro Gly Thr Thr Val Gly Val Val Cys Ala Thr Asp Arg Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Leu Gln Gln Thr 
        275                 280                 285             


Pro Arg Ser Pro Gly Leu Phe Ser Val His Pro Ser Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Val Ser His Tyr Leu Asp Arg Glu Val Val Asp Lys Tyr Ser 
305                 310                 315                 320 


Leu Ile Met Lys Val Gln Asp Met Asp Gly Gln Phe Phe Gly Leu Ile 
                325                 330                 335     


Gly Thr Ser Thr Cys Ile Ile Thr Val Thr Asp Ser Asn Asp Asn Ala 
            340                 345                 350         


Pro Thr Phe Arg Gln Asn Ala Tyr Glu Ala Phe Val Glu Glu Asn Ala 
        355                 360                 365             


Phe Asn Val Glu Ile Leu Arg Ile Pro Ile Glu Asp Lys Asp Leu Ile 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Val Asn Phe Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly His Phe Lys Ile Ser Thr Asp Lys Glu Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Ser Val Val Lys Pro Leu Asn Tyr Glu Glu Asn Arg Gln Val Asn 
            420                 425                 430         


Leu Glu Ile Gly Val Asn Asn Glu Ala Pro Phe Ala Arg Asp Ile Pro 
        435                 440                 445             


Arg Val Thr Ala Leu Asn Arg Ala Leu Val Thr Val His Val Arg Asp 
    450                 455                 460                 


Leu Asp Glu Gly Pro Glu Cys Thr Pro Ala Ala Gln Tyr Val Arg Ile 
465                 470                 475                 480 


Lys Glu Asn Leu Ala Val Gly Ser Lys Ile Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Asn Arg Asn Gly Asn Gly Leu Arg Tyr Lys Lys Leu His 
            500                 505                 510         


Asp Pro Lys Gly Trp Ile Thr Ile Asp Glu Ile Ser Gly Ser Ile Ile 
        515                 520                 525             


Thr Ser Lys Ile Leu Asp Arg Glu Val Glu Thr Pro Lys Asn Glu Leu 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ile Asp Lys Asp Asp Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Ala Val Asn Ile Glu Asp Val Asn Asp Asn Pro Pro Glu 
                565                 570                 575     


Ile Leu Gln Glu Tyr Val Val Ile Cys Lys Pro Lys Met Gly Tyr Thr 
            580                 585                 590         


Asp Ile Leu Ala Val Asp Pro Asp Glu Pro Val His Gly Ala Pro Phe 
        595                 600                 605             


Tyr Phe Ser Leu Pro Asn Thr Ser Pro Glu Ile Ser Arg Leu Trp Ser 
    610                 615                 620                 


Leu Thr Lys Val Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Lys Asn 
625                 630                 635                 640 


Ala Gly Phe Gln Glu Tyr Thr Ile Pro Ile Thr Val Lys Asp Arg Ala 
                645                 650                 655     


Gly Gln Ala Ala Thr Lys Leu Leu Arg Val Asn Leu Cys Glu Cys Thr 
            660                 665                 670         


His Pro Thr Gln Cys Arg Ala Thr Ser Arg Ser Thr Gly Val Ile Leu 
        675                 680                 685             


Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile Ala Leu Leu Phe 
    690                 695                 700                 


Ser Val Leu Leu Thr Leu Val Cys Gly Val Phe Gly Ala Thr Lys Gly 
705                 710                 715                 720 


Lys Arg Phe Pro Glu Asp Leu Ala Gln Gln Asn Leu Ile Ile Ser Asn 
                725                 730                 735     


Thr Glu Ala Pro Gly Asp Asp Arg Val Cys Ser Ala Asn Gly Phe Met 
            740                 745                 750         


Thr Gln Thr Thr Asn Asn Ser Ser Gln Gly Phe Cys Gly Thr Met Gly 
        755                 760                 765             


Ser Gly Met Lys Asn Gly Gly Gln Glu Thr Ile Glu Met Met Lys Gly 
    770                 775                 780                 


Gly Asn Gln Thr Leu Glu Ser Cys Arg Gly Ala Gly His His His Thr 
785                 790                 795                 800 


Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val Asp Asn Cys Arg Tyr 
                805                 810                 815     


Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro Arg Leu Gly Glu Lys 
            820                 825                 830         


Leu His Arg Cys Asn Gln Asn Glu Asp Arg Met Pro Ser Gln Asp Tyr 
        835                 840                 845             


Val Leu Thr Tyr Asn Tyr Glu Gly Arg Gly Ser Pro Ala Gly Ser Val 
    850                 855                 860                 


Gly Cys Cys Ser Glu Lys Gln Glu Glu Asp Gly Leu Asp Phe Leu Asn 
865                 870                 875                 880 


Asn Leu Glu Pro Lys Phe Ile Thr Leu Ala Glu Ala Cys Thr Lys Arg 
                885                 890                 895     


<210>  3272
<211>  2012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSCAM__Homo_sapiens__NP_001380

<400>  3272

Met Trp Ile Leu Ala Leu Ser Leu Phe Gln Ser Phe Ala Asn Val Phe 
1               5                   10                  15      


Ser Glu Asp Leu His Ser Ser Leu Tyr Phe Val Asn Ala Ser Leu Gln 
            20                  25                  30          


Glu Val Val Phe Ala Ser Thr Thr Gly Thr Leu Val Pro Cys Pro Ala 
        35                  40                  45              


Ala Gly Ile Pro Pro Val Thr Leu Arg Trp Tyr Leu Ala Thr Gly Glu 
    50                  55                  60                  


Glu Ile Tyr Asp Val Pro Gly Ile Arg His Val His Pro Asn Gly Thr 
65                  70                  75                  80  


Leu Gln Ile Phe Pro Phe Pro Pro Ser Ser Phe Ser Thr Leu Ile His 
                85                  90                  95      


Asp Asn Thr Tyr Tyr Cys Thr Ala Glu Asn Pro Ser Gly Lys Ile Arg 
            100                 105                 110         


Ser Gln Asp Val His Ile Lys Ala Val Leu Arg Glu Pro Tyr Thr Val 
        115                 120                 125             


Arg Val Glu Asp Gln Lys Thr Met Arg Gly Asn Val Ala Val Phe Lys 
    130                 135                 140                 


Cys Ile Ile Pro Ser Ser Val Glu Ala Tyr Ile Thr Val Val Ser Trp 
145                 150                 155                 160 


Glu Lys Asp Thr Val Ser Leu Val Ser Gly Ser Arg Phe Leu Ile Thr 
                165                 170                 175     


Ser Thr Gly Ala Leu Tyr Ile Lys Asp Val Gln Asn Glu Asp Gly Leu 
            180                 185                 190         


Tyr Asn Tyr Arg Cys Ile Thr Arg His Arg Tyr Thr Gly Glu Thr Arg 
        195                 200                 205             


Gln Ser Asn Ser Ala Arg Leu Phe Val Ser Asp Pro Ala Asn Ser Ala 
    210                 215                 220                 


Pro Ser Ile Leu Asp Gly Phe Asp His Arg Lys Ala Met Ala Gly Gln 
225                 230                 235                 240 


Arg Val Glu Leu Pro Cys Lys Ala Leu Gly His Pro Glu Pro Asp Tyr 
                245                 250                 255     


Arg Trp Leu Lys Asp Asn Met Pro Leu Glu Leu Ser Gly Arg Phe Gln 
            260                 265                 270         


Lys Thr Val Thr Gly Leu Leu Ile Glu Asn Ile Arg Pro Ser Asp Ser 
        275                 280                 285             


Gly Ser Tyr Val Cys Glu Val Ser Asn Arg Tyr Gly Thr Ala Lys Val 
    290                 295                 300                 


Ile Gly Arg Leu Tyr Val Lys Gln Pro Leu Lys Ala Thr Ile Ser Pro 
305                 310                 315                 320 


Arg Lys Val Lys Ser Ser Val Gly Ser Gln Val Ser Leu Ser Cys Ser 
                325                 330                 335     


Val Thr Gly Thr Glu Asp Gln Glu Leu Ser Trp Tyr Arg Asn Gly Glu 
            340                 345                 350         


Ile Leu Asn Pro Gly Lys Asn Val Arg Ile Thr Gly Ile Asn His Glu 
        355                 360                 365             


Asn Leu Ile Met Asp His Met Val Lys Ser Asp Gly Gly Ala Tyr Gln 
    370                 375                 380                 


Cys Phe Val Arg Lys Asp Lys Leu Ser Ala Gln Asp Tyr Val Gln Val 
385                 390                 395                 400 


Val Leu Glu Asp Gly Thr Pro Lys Ile Ile Ser Ala Phe Ser Glu Lys 
                405                 410                 415     


Val Val Ser Pro Ala Glu Pro Val Ser Leu Met Cys Asn Val Lys Gly 
            420                 425                 430         


Thr Pro Leu Pro Thr Ile Thr Trp Thr Leu Asp Asp Asp Pro Ile Leu 
        435                 440                 445             


Lys Gly Gly Ser His Arg Ile Ser Gln Met Ile Thr Ser Glu Gly Asn 
    450                 455                 460                 


Val Val Ser Tyr Leu Asn Ile Ser Ser Ser Gln Val Arg Asp Gly Gly 
465                 470                 475                 480 


Val Tyr Arg Cys Thr Ala Asn Asn Ser Ala Gly Val Val Leu Tyr Gln 
                485                 490                 495     


Ala Arg Ile Asn Val Arg Gly Pro Ala Ser Ile Arg Pro Met Lys Asn 
            500                 505                 510         


Ile Thr Ala Ile Ala Gly Arg Asp Thr Tyr Ile His Cys Arg Val Ile 
        515                 520                 525             


Gly Tyr Pro Tyr Tyr Ser Ile Lys Trp Tyr Lys Asn Ser Asn Leu Leu 
    530                 535                 540                 


Pro Phe Asn His Arg Gln Val Ala Phe Glu Asn Asn Gly Thr Leu Lys 
545                 550                 555                 560 


Leu Ser Asp Val Gln Lys Glu Val Asp Glu Gly Glu Tyr Thr Cys Asn 
                565                 570                 575     


Val Leu Val Gln Pro Gln Leu Ser Thr Ser Gln Ser Val His Val Thr 
            580                 585                 590         


Val Lys Val Pro Pro Phe Ile Gln Pro Phe Glu Phe Pro Arg Phe Ser 
        595                 600                 605             


Ile Gly Gln Arg Val Phe Ile Pro Cys Val Val Val Ser Gly Asp Leu 
    610                 615                 620                 


Pro Ile Thr Ile Thr Trp Gln Lys Asp Gly Arg Pro Ile Pro Gly Ser 
625                 630                 635                 640 


Leu Gly Val Thr Ile Asp Asn Ile Asp Phe Thr Ser Ser Leu Arg Ile 
                645                 650                 655     


Ser Asn Leu Ser Leu Met His Asn Gly Asn Tyr Thr Cys Ile Ala Arg 
            660                 665                 670         


Asn Glu Ala Ala Ala Val Glu His Gln Ser Gln Leu Ile Val Arg Val 
        675                 680                 685             


Pro Pro Lys Phe Val Val Gln Pro Arg Asp Gln Asp Gly Ile Tyr Gly 
    690                 695                 700                 


Lys Ala Val Ile Leu Asn Cys Ser Ala Glu Gly Tyr Pro Val Pro Thr 
705                 710                 715                 720 


Ile Val Trp Lys Phe Ser Lys Gly Ala Gly Val Pro Gln Phe Gln Pro 
                725                 730                 735     


Ile Ala Leu Asn Gly Arg Ile Gln Val Leu Ser Asn Gly Ser Leu Leu 
            740                 745                 750         


Ile Lys His Val Val Glu Glu Asp Ser Gly Tyr Tyr Leu Cys Lys Val 
        755                 760                 765             


Ser Asn Asp Val Gly Ala Asp Val Ser Lys Ser Met Tyr Leu Thr Val 
    770                 775                 780                 


Lys Ile Pro Ala Met Ile Thr Ser Tyr Pro Asn Thr Thr Leu Ala Thr 
785                 790                 795                 800 


Gln Gly Gln Lys Lys Glu Met Ser Cys Thr Ala His Gly Glu Lys Pro 
                805                 810                 815     


Ile Ile Val Arg Trp Glu Lys Glu Asp Arg Ile Ile Asn Pro Glu Met 
            820                 825                 830         


Ala Arg Tyr Leu Val Ser Thr Lys Glu Val Gly Glu Glu Val Ile Ser 
        835                 840                 845             


Thr Leu Gln Ile Leu Pro Thr Val Arg Glu Asp Ser Gly Phe Phe Ser 
    850                 855                 860                 


Cys His Ala Ile Asn Ser Tyr Gly Glu Asp Arg Gly Ile Ile Gln Leu 
865                 870                 875                 880 


Thr Val Gln Glu Pro Pro Asp Pro Pro Glu Ile Glu Ile Lys Asp Val 
                885                 890                 895     


Lys Ala Arg Thr Ile Thr Leu Arg Trp Thr Met Gly Phe Asp Gly Asn 
            900                 905                 910         


Ser Pro Ile Thr Gly Tyr Asp Ile Glu Cys Lys Asn Lys Ser Asp Ser 
        915                 920                 925             


Trp Asp Ser Ala Gln Arg Thr Lys Asp Val Ser Pro Gln Leu Asn Ser 
    930                 935                 940                 


Ala Thr Ile Ile Asp Ile His Pro Ser Ser Thr Tyr Ser Ile Arg Met 
945                 950                 955                 960 


Tyr Ala Lys Asn Arg Ile Gly Lys Ser Glu Pro Ser Asn Glu Leu Thr 
                965                 970                 975     


Ile Thr Ala Asp Glu Ala Ala Pro Asp Gly Pro Pro Gln Glu Val His 
            980                 985                 990         


Leu Glu Pro Ile Ser Ser Gln Ser  Ile Arg Val Thr Trp  Lys Ala Pro 
        995                 1000                 1005             


Lys Lys  His Leu Gln Asn Gly  Ile Ile Arg Gly Tyr  Gln Ile Gly 
    1010                 1015                 1020             


Tyr Arg  Glu Tyr Ser Thr Gly  Gly Asn Phe Gln Phe  Asn Ile Ile 
    1025                 1030                 1035             


Ser Val  Asp Thr Ser Gly Asp  Ser Glu Val Tyr Thr  Leu Asp Asn 
    1040                 1045                 1050             


Leu Asn  Lys Phe Thr Gln Tyr  Gly Leu Val Val Gln  Ala Cys Asn 
    1055                 1060                 1065             


Arg Ala  Gly Thr Gly Pro Ser  Ser Gln Glu Ile Ile  Thr Thr Thr 
    1070                 1075                 1080             


Leu Glu  Asp Val Pro Ser Tyr  Pro Pro Glu Asn Val  Gln Ala Ile 
    1085                 1090                 1095             


Ala Thr  Ser Pro Glu Ser Ile  Ser Ile Ser Trp Ser  Thr Leu Ser 
    1100                 1105                 1110             


Lys Glu  Ala Leu Asn Gly Ile  Leu Gln Gly Phe Arg  Val Ile Tyr 
    1115                 1120                 1125             


Trp Ala  Asn Leu Met Asp Gly  Glu Leu Gly Glu Ile  Lys Asn Ile 
    1130                 1135                 1140             


Thr Thr  Thr Gln Pro Ser Leu  Glu Leu Asp Gly Leu  Glu Lys Tyr 
    1145                 1150                 1155             


Thr Asn  Tyr Ser Ile Gln Val  Leu Ala Phe Thr Arg  Ala Gly Asp 
    1160                 1165                 1170             


Gly Val  Arg Ser Glu Gln Ile  Phe Thr Arg Thr Lys  Glu Asp Val 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ala Gly Val  Lys Ala Ala Ala Ala  Ser Ala Ser 
    1190                 1195                 1200             


Met Val  Phe Val Ser Trp Leu  Pro Pro Leu Lys Leu  Asn Gly Ile 
    1205                 1210                 1215             


Ile Arg  Lys Tyr Thr Val Phe  Cys Ser His Pro Tyr  Pro Thr Val 
    1220                 1225                 1230             


Ile Ser  Glu Phe Glu Ala Ser  Pro Asp Ser Phe Ser  Tyr Arg Ile 
    1235                 1240                 1245             


Pro Asn  Leu Ser Arg Asn Arg  Gln Tyr Ser Val Trp  Val Val Ala 
    1250                 1255                 1260             


Val Thr  Ser Ala Gly Arg Gly  Asn Ser Ser Glu Ile  Ile Thr Val 
    1265                 1270                 1275             


Glu Pro  Leu Ala Lys Ala Pro  Ala Arg Ile Leu Thr  Phe Ser Gly 
    1280                 1285                 1290             


Thr Val  Thr Thr Pro Trp Met  Lys Asp Ile Val Leu  Pro Cys Lys 
    1295                 1300                 1305             


Ala Val  Gly Asp Pro Ser Pro  Ala Val Lys Trp Met  Lys Asp Ser 
    1310                 1315                 1320             


Asn Gly  Thr Pro Ser Leu Val  Thr Ile Asp Gly Arg  Arg Ser Ile 
    1325                 1330                 1335             


Phe Ser  Asn Gly Ser Phe Ile  Ile Arg Thr Val Lys  Ala Glu Asp 
    1340                 1345                 1350             


Ser Gly  Tyr Tyr Ser Cys Ile  Ala Asn Asn Asn Trp  Gly Ser Asp 
    1355                 1360                 1365             


Glu Ile  Ile Leu Asn Leu Gln  Val Gln Val Pro Pro  Asp Gln Pro 
    1370                 1375                 1380             


Arg Leu  Thr Val Ser Lys Thr  Thr Ser Ser Ser Ile  Thr Leu Ser 
    1385                 1390                 1395             


Trp Leu  Pro Gly Asp Asn Gly  Gly Ser Ser Ile Arg  Gly Tyr Ile 
    1400                 1405                 1410             


Leu Gln  Tyr Ser Glu Asp Asn  Ser Glu Gln Trp Gly  Ser Phe Pro 
    1415                 1420                 1425             


Ile Ser  Pro Ser Glu Arg Ser  Tyr Arg Leu Glu Asn  Leu Lys Cys 
    1430                 1435                 1440             


Gly Thr  Trp Tyr Lys Phe Thr  Leu Thr Ala Gln Asn  Gly Val Gly 
    1445                 1450                 1455             


Pro Gly  Arg Ile Ser Glu Ile  Ile Glu Ala Lys Thr  Leu Gly Lys 
    1460                 1465                 1470             


Glu Pro  Gln Phe Ser Lys Glu  Gln Glu Leu Phe Ala  Ser Ile Asn 
    1475                 1480                 1485             


Thr Thr  Arg Val Arg Leu Asn  Leu Ile Gly Trp Asn  Asp Gly Gly 
    1490                 1495                 1500             


Cys Pro  Ile Thr Ser Phe Thr  Leu Glu Tyr Arg Pro  Phe Gly Thr 
    1505                 1510                 1515             


Thr Val  Trp Thr Thr Ala Gln  Arg Thr Ser Leu Ser  Lys Ser Tyr 
    1520                 1525                 1530             


Ile Leu  Tyr Asp Leu Gln Glu  Ala Thr Trp Tyr Glu  Leu Gln Met 
    1535                 1540                 1545             


Arg Val  Cys Asn Ser Ala Gly  Cys Ala Glu Lys Gln  Ala Asn Phe 
    1550                 1555                 1560             


Ala Thr  Leu Asn Tyr Asp Gly  Ser Thr Ile Pro Pro  Leu Ile Lys 
    1565                 1570                 1575             


Ser Val  Val Gln Asn Glu Glu  Gly Leu Thr Thr Asn  Glu Gly Leu 
    1580                 1585                 1590             


Lys Met  Leu Val Thr Ile Ser  Cys Ile Leu Val Gly  Val Leu Leu 
    1595                 1600                 1605             


Leu Phe  Val Leu Leu Leu Val  Val Arg Arg Arg Arg  Arg Glu Gln 
    1610                 1615                 1620             


Arg Leu  Lys Arg Leu Arg Asp  Ala Lys Ser Leu Ala  Glu Met Leu 
    1625                 1630                 1635             


Met Ser  Lys Asn Thr Arg Thr  Ser Asp Thr Leu Ser  Lys Gln Gln 
    1640                 1645                 1650             


Gln Thr  Leu Arg Met His Ile  Asp Ile Pro Arg Ala  Gln Leu Leu 
    1655                 1660                 1665             


Ile Glu  Glu Arg Asp Thr Met  Glu Thr Ile Asp Asp  Arg Ser Thr 
    1670                 1675                 1680             


Val Leu  Leu Thr Asp Ala Asp  Phe Gly Glu Ala Ala  Lys Gln Lys 
    1685                 1690                 1695             


Ser Leu  Thr Val Thr His Thr  Val His Tyr Gln Ser  Val Ser Gln 
    1700                 1705                 1710             


Ala Thr  Gly Pro Leu Val Asp  Val Ser Asp Ala Arg  Pro Gly Thr 
    1715                 1720                 1725             


Asn Pro  Thr Thr Arg Arg Asn  Ala Lys Ala Gly Pro  Thr Ala Arg 
    1730                 1735                 1740             


Asn Arg  Tyr Ala Ser Gln Trp  Thr Leu Asn Arg Pro  His Pro Thr 
    1745                 1750                 1755             


Ile Ser  Ala His Thr Leu Thr  Thr Asp Trp Arg Leu  Pro Thr Pro 
    1760                 1765                 1770             


Arg Ala  Ala Gly Ser Val Asp  Lys Glu Ser Asp Ser  Tyr Ser Val 
    1775                 1780                 1785             


Ser Pro  Ser Gln Asp Thr Asp  Arg Ala Arg Ser Ser  Met Val Ser 
    1790                 1795                 1800             


Thr Glu  Ser Ala Ser Ser Thr  Tyr Glu Glu Leu Ala  Arg Ala Tyr 
    1805                 1810                 1815             


Glu His  Ala Lys Met Glu Glu  Gln Leu Arg His Ala  Lys Phe Thr 
    1820                 1825                 1830             


Ile Thr  Glu Cys Phe Ile Ser  Asp Thr Ser Ser Glu  Gln Leu Thr 
    1835                 1840                 1845             


Ala Gly  Thr Asn Glu Tyr Thr  Asp Ser Leu Thr Ser  Ser Thr Pro 
    1850                 1855                 1860             


Ser Glu  Ser Gly Ile Cys Arg  Phe Thr Ala Ser Pro  Pro Lys Pro 
    1865                 1870                 1875             


Gln Asp  Gly Gly Arg Val Met  Asn Met Ala Val Pro  Lys Ala His 
    1880                 1885                 1890             


Arg Pro  Gly Asp Leu Ile His  Leu Pro Pro Tyr Leu  Arg Met Asp 
    1895                 1900                 1905             


Phe Leu  Leu Asn Arg Gly Gly  Pro Gly Thr Ser Arg  Asp Leu Ser 
    1910                 1915                 1920             


Leu Gly  Gln Ala Cys Leu Glu  Pro Gln Lys Ser Arg  Thr Leu Lys 
    1925                 1930                 1935             


Arg Pro  Thr Val Leu Glu Pro  Ile Pro Met Glu Ala  Ala Ser Ser 
    1940                 1945                 1950             


Ala Ser  Ser Thr Arg Glu Gly  Gln Ser Trp Gln Pro  Gly Ala Val 
    1955                 1960                 1965             


Ala Thr  Leu Pro Gln Arg Glu  Gly Ala Glu Leu Gly  Gln Ala Ala 
    1970                 1975                 1980             


Lys Met  Ser Ser Ser Gln Glu  Ser Leu Leu Asp Ser  Arg Gly His 
    1985                 1990                 1995             


Leu Lys  Gly Asn Asn Pro Tyr  Ala Lys Ser Tyr Thr  Leu Val 
    2000                 2005                 2010         


<210>  3273
<211>  2113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSCAML1__Homo_sapiens__NP_065744

<400>  3273

Met Thr Gly Ala Gly Glu Pro Arg Arg Glu Glu Pro Pro Pro Gln Pro 
1               5                   10                  15      


Ser Ala Gly Leu Arg Ser Arg Glu Ser Gly Ala Pro Ser Ala Gly Gly 
            20                  25                  30          


Trp Glu Arg Ala Glu Arg Gly Arg Gly Ala Ala Ala Arg Pro Ala Thr 
        35                  40                  45              


Gly Pro Pro Pro Arg Arg Ile Gly Pro Leu Tyr Gly Met Trp Leu Val 
    50                  55                  60                  


Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys Ala Arg Pro Glu Asp 
65                  70                  75                  80  


Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser Leu Gln Gln Val Thr 
                85                  90                  95      


Phe Ser Ser Ser Val Gly Val Val Val Pro Cys Pro Ala Ala Gly Ser 
            100                 105                 110         


Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr Gly Asp Asp Ile Tyr 
        115                 120                 125             


Asp Val Pro His Ile Arg His Val His Ala Asn Gly Thr Leu Gln Leu 
    130                 135                 140                 


Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe Ile His Asp Asn Asp 
145                 150                 155                 160 


Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys Ile Arg Ser Pro Asn 
                165                 170                 175     


Ile Arg Val Lys Ala Val Phe Arg Glu Pro Tyr Thr Val Arg Val Glu 
            180                 185                 190         


Asp Gln Arg Ser Met Arg Gly Asn Val Ala Val Phe Lys Cys Leu Ile 
        195                 200                 205             


Pro Ser Ser Val Gln Glu Tyr Val Ser Val Val Ser Trp Glu Lys Asp 
    210                 215                 220                 


Thr Val Ser Ile Ile Pro Glu His Arg Phe Phe Ile Thr Tyr His Gly 
225                 230                 235                 240 


Gly Leu Tyr Ile Ser Asp Val Gln Lys Glu Asp Ala Leu Ser Thr Tyr 
                245                 250                 255     


Arg Cys Ile Thr Lys His Lys Tyr Ser Gly Glu Thr Arg Gln Ser Asn 
            260                 265                 270         


Gly Ala Arg Leu Ser Val Thr Asp Pro Ala Glu Ser Ile Pro Thr Ile 
        275                 280                 285             


Leu Asp Gly Phe His Ser Gln Glu Val Trp Ala Gly His Thr Val Glu 
    290                 295                 300                 


Leu Pro Cys Thr Ala Ser Gly Tyr Pro Ile Pro Ala Ile Arg Trp Leu 
305                 310                 315                 320 


Lys Asp Gly Arg Pro Leu Pro Ala Asp Ser Arg Trp Thr Lys Arg Ile 
                325                 330                 335     


Thr Gly Leu Thr Ile Ser Asp Leu Arg Thr Glu Asp Ser Gly Thr Tyr 
            340                 345                 350         


Ile Cys Glu Val Thr Asn Thr Phe Gly Ser Ala Glu Ala Thr Gly Ile 
        355                 360                 365             


Leu Met Val Ile Asp Pro Leu His Val Thr Leu Thr Pro Lys Lys Leu 
    370                 375                 380                 


Lys Thr Gly Ile Gly Ser Thr Val Ile Leu Ser Cys Ala Leu Thr Gly 
385                 390                 395                 400 


Ser Pro Glu Phe Thr Ile Arg Trp Tyr Arg Asn Thr Glu Leu Val Leu 
                405                 410                 415     


Pro Asp Glu Ala Ile Ser Ile Arg Gly Leu Ser Asn Glu Thr Leu Leu 
            420                 425                 430         


Ile Thr Ser Ala Gln Lys Ser His Ser Gly Ala Tyr Gln Cys Phe Ala 
        435                 440                 445             


Thr Arg Lys Ala Gln Thr Ala Gln Asp Phe Ala Ile Ile Ala Leu Glu 
    450                 455                 460                 


Asp Gly Thr Pro Arg Ile Val Ser Ser Phe Ser Glu Lys Val Val Asn 
465                 470                 475                 480 


Pro Gly Glu Gln Phe Ser Leu Met Cys Ala Ala Lys Gly Ala Pro Pro 
                485                 490                 495     


Pro Thr Val Thr Trp Ala Leu Asp Asp Glu Pro Ile Val Arg Asp Gly 
            500                 505                 510         


Ser His Arg Thr Asn Gln Tyr Thr Met Ser Asp Gly Thr Thr Ile Ser 
        515                 520                 525             


His Met Asn Val Thr Gly Pro Gln Ile Arg Asp Gly Gly Val Tyr Arg 
    530                 535                 540                 


Cys Thr Ala Arg Asn Leu Val Gly Ser Ala Glu Tyr Gln Ala Arg Ile 
545                 550                 555                 560 


Asn Val Arg Gly Pro Pro Ser Ile Arg Ala Met Arg Asn Ile Thr Ala 
                565                 570                 575     


Val Ala Gly Arg Asp Thr Leu Ile Asn Cys Arg Val Ile Gly Tyr Pro 
            580                 585                 590         


Tyr Tyr Ser Ile Lys Trp Tyr Lys Asp Ala Leu Leu Leu Pro Asp Asn 
        595                 600                 605             


His Arg Gln Val Val Phe Glu Asn Gly Thr Leu Lys Leu Thr Asp Val 
    610                 615                 620                 


Gln Lys Gly Met Asp Glu Gly Glu Tyr Leu Cys Ser Val Leu Ile Gln 
625                 630                 635                 640 


Pro Gln Leu Ser Ile Ser Gln Ser Val His Val Ala Val Lys Val Pro 
                645                 650                 655     


Pro Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala Ser Ile Gly Gln Leu 
            660                 665                 670         


Leu Tyr Ile Pro Cys Val Val Ser Ser Gly Asp Met Pro Ile Arg Ile 
        675                 680                 685             


Thr Trp Arg Lys Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val Thr 
    690                 695                 700                 


Ile Glu Ser Lys Glu Phe Met Ser Ser Leu Gln Ile Ser Ser Val Ser 
705                 710                 715                 720 


Leu Lys His Asn Gly Asn Tyr Thr Cys Ile Ala Ser Asn Ala Ala Ala 
                725                 730                 735     


Thr Val Ser Arg Glu Arg Gln Leu Ile Val Arg Val Pro Pro Arg Phe 
            740                 745                 750         


Val Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr Gly Lys Ala Gly Val 
        755                 760                 765             


Leu Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro Lys Val Met Trp Lys 
    770                 775                 780                 


His Ala Lys Gly Ser Gly Asn Pro Gln Gln Tyr His Pro Val Pro Leu 
785                 790                 795                 800 


Thr Gly Arg Ile Gln Ile Leu Pro Asn Ser Ser Leu Leu Ile Arg His 
                805                 810                 815     


Val Leu Glu Glu Asp Ile Gly Tyr Tyr Leu Cys Gln Ala Ser Asn Gly 
            820                 825                 830         


Val Gly Thr Asp Ile Ser Lys Ser Met Phe Leu Thr Val Lys Ile Pro 
        835                 840                 845             


Ala Met Ile Thr Ser His Pro Asn Thr Thr Ile Ala Ile Lys Gly His 
    850                 855                 860                 


Ala Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu Arg Pro Ile Ile Ile 
865                 870                 875                 880 


Arg Trp Glu Lys Gly Asp Thr Val Ile Asp Pro Asp Arg Val Met Arg 
                885                 890                 895     


Tyr Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu Val Val Ser Thr Leu 
            900                 905                 910         


Lys Leu Lys Pro Ala Asp Arg Gly Asp Ser Val Phe Phe Ser Cys His 
        915                 920                 925             


Ala Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu Ile Gln Leu Thr Val 
    930                 935                 940                 


Gln Glu Pro Pro Asp Pro Pro Glu Leu Glu Ile Arg Glu Val Lys Ala 
945                 950                 955                 960 


Arg Ser Met Asn Leu Arg Trp Thr Gln Arg Phe Asp Gly Asn Ser Ile 
                965                 970                 975     


Ile Thr Gly Phe Asp Ile Glu Tyr Lys Asn Lys Ser Asp Ser Trp Asp 
            980                 985                 990         


Phe Lys Gln Ser Thr Arg Asn Ile  Ser Pro Thr Ile Asn  Gln Ala Asn 
        995                 1000                 1005             


Ile Val  Asp Leu His Pro Ala  Ser Val Tyr Ser Ile  Arg Met Tyr 
    1010                 1015                 1020             


Ser Phe  Asn Lys Ile Gly Arg  Ser Glu Pro Ser Lys  Glu Leu Thr 
    1025                 1030                 1035             


Ile Ser  Thr Glu Glu Ala Ala  Pro Asp Gly Pro Pro  Met Asp Val 
    1040                 1045                 1050             


Thr Leu  Gln Pro Val Thr Ser  Gln Ser Ile Gln Val  Thr Trp Lys 
    1055                 1060                 1065             


Ala Pro  Lys Lys Glu Leu Gln  Asn Gly Val Ile Arg  Gly Tyr Gln 
    1070                 1075                 1080             


Ile Gly  Tyr Arg Glu Asn Ser  Pro Gly Ser Asn Gly  Gln Tyr Ser 
    1085                 1090                 1095             


Ile Val  Glu Met Lys Ala Thr  Gly Asp Ser Glu Val  Tyr Thr Leu 
    1100                 1105                 1110             


Asp Asn  Leu Lys Lys Phe Ala  Gln Tyr Gly Val Val  Val Gln Ala 
    1115                 1120                 1125             


Phe Asn  Arg Ala Gly Thr Gly  Pro Ser Ser Ser Glu  Ile Asn Ala 
    1130                 1135                 1140             


Thr Thr  Leu Glu Asp Val Pro  Ser Gln Pro Pro Glu  Asn Val Arg 
    1145                 1150                 1155             


Ala Leu  Ser Ile Thr Ser Asp  Val Ala Val Ile Ser  Trp Ser Glu 
    1160                 1165                 1170             


Pro Pro  Arg Ser Thr Leu Asn  Gly Val Leu Lys Gly  Tyr Arg Val 
    1175                 1180                 1185             


Ile Phe  Trp Ser Leu Tyr Val  Asp Gly Glu Trp Gly  Glu Met Gln 
    1190                 1195                 1200             


Asn Ile  Thr Thr Thr Arg Glu  Arg Val Glu Leu Arg  Gly Met Glu 
    1205                 1210                 1215             


Lys Phe  Thr Asn Tyr Ser Val  Gln Val Leu Ala Tyr  Thr Gln Ala 
    1220                 1225                 1230             


Gly Asp  Gly Val Arg Ser Ser  Val Leu Tyr Ile Gln  Thr Lys Glu 
    1235                 1240                 1245             


Asp Val  Pro Gly Pro Pro Ala  Gly Ile Lys Ala Val  Pro Ser Ser 
    1250                 1255                 1260             


Ala Ser  Ser Val Val Val Ser  Trp Leu Pro Pro Thr  Lys Pro Asn 
    1265                 1270                 1275             


Gly Val  Ile Arg Lys Tyr Thr  Ile Phe Cys Ser Ser  Pro Gly Ser 
    1280                 1285                 1290             


Gly Gln  Pro Ala Pro Ser Glu  Tyr Glu Thr Ser Pro  Glu Gln Leu 
    1295                 1300                 1305             


Phe Tyr  Arg Ile Ala His Leu  Asn Arg Gly Gln Gln  Tyr Leu Leu 
    1310                 1315                 1320             


Trp Val  Ala Ala Val Thr Ser  Ala Gly Arg Gly Asn  Ser Ser Glu 
    1325                 1330                 1335             


Lys Val  Thr Ile Glu Pro Ala  Gly Lys Ala Pro Ala  Lys Ile Ile 
    1340                 1345                 1350             


Ser Phe  Gly Gly Thr Val Thr  Thr Pro Trp Met Lys  Asp Val Arg 
    1355                 1360                 1365             


Leu Pro  Cys Asn Ser Val Gly  Asp Pro Ala Pro Ala  Val Lys Trp 
    1370                 1375                 1380             


Thr Lys  Asp Ser Glu Asp Ser  Ala Ile Pro Val Ser  Met Asp Gly 
    1385                 1390                 1395             


His Arg  Leu Ile His Thr Asn  Gly Thr Leu Leu Leu  Arg Ala Val 
    1400                 1405                 1410             


Lys Ala  Glu Asp Ser Gly Tyr  Tyr Thr Cys Thr Ala  Thr Asn Thr 
    1415                 1420                 1425             


Gly Gly  Phe Asp Thr Ile Ile  Val Asn Leu Leu Val  Gln Val Pro 
    1430                 1435                 1440             


Pro Asp  Gln Pro Arg Leu Thr  Val Ser Lys Thr Ser  Ala Ser Ser 
    1445                 1450                 1455             


Ile Thr  Leu Thr Trp Ile Pro  Gly Asp Asn Gly Gly  Ser Ser Ile 
    1460                 1465                 1470             


Arg Gly  Phe Val Leu Gln Tyr  Ser Val Asp Asn Ser  Glu Glu Trp 
    1475                 1480                 1485             


Lys Asp  Val Phe Ile Ser Ser  Ser Glu Arg Ser Phe  Lys Leu Asp 
    1490                 1495                 1500             


Ser Leu  Lys Cys Gly Thr Trp  Tyr Lys Val Lys Leu  Ala Ala Lys 
    1505                 1510                 1515             


Asn Ser  Val Gly Ser Gly Arg  Ile Ser Glu Ile Ile  Glu Ala Lys 
    1520                 1525                 1530             


Thr His  Gly Arg Glu Pro Ser  Phe Ser Lys Asp Gln  His Leu Phe 
    1535                 1540                 1545             


Thr His  Ile Asn Ser Thr His  Ala Arg Leu Asn Leu  Gln Gly Trp 
    1550                 1555                 1560             


Asn Asn  Gly Gly Cys Pro Ile  Thr Ala Ile Val Leu  Glu Tyr Arg 
    1565                 1570                 1575             


Pro Lys  Gly Thr Trp Ala Trp  Gln Gly Leu Arg Ala  Asn Ser Ser 
    1580                 1585                 1590             


Gly Glu  Val Phe Leu Thr Glu  Leu Arg Glu Ala Thr  Trp Tyr Glu 
    1595                 1600                 1605             


Leu Arg  Met Arg Ala Cys Asn  Ser Ala Gly Cys Gly  Asn Glu Thr 
    1610                 1615                 1620             


Ala Gln  Phe Ala Thr Leu Asp  Tyr Asp Gly Ser Thr  Ile Pro Pro 
    1625                 1630                 1635             


Ile Lys  Ser Ala Gln Gly Glu  Gly Asp Asp Val Lys  Lys Leu Phe 
    1640                 1645                 1650             


Thr Ile  Gly Cys Pro Val Ile  Leu Ala Thr Leu Gly  Val Ala Leu 
    1655                 1660                 1665             


Leu Phe  Ile Val Arg Lys Lys  Arg Lys Glu Lys Arg  Leu Lys Arg 
    1670                 1675                 1680             


Leu Arg  Asp Ala Lys Ser Leu  Ala Glu Met Leu Ile  Ser Lys Asn 
    1685                 1690                 1695             


Asn Arg  Ser Phe Asp Thr Pro  Val Lys Gly Pro Pro  Gln Gly Pro 
    1700                 1705                 1710             


Arg Leu  His Ile Asp Ile Pro  Arg Val Gln Leu Leu  Ile Glu Asp 
    1715                 1720                 1725             


Lys Glu  Gly Ile Lys Gln Leu  Gly Asp Asp Lys Ala  Thr Ile Pro 
    1730                 1735                 1740             


Val Thr  Asp Ala Glu Phe Ser  Gln Ala Val Asn Pro  Gln Ser Phe 
    1745                 1750                 1755             


Cys Thr  Gly Val Ser Leu His  His Pro Thr Leu Ile  Gln Ser Thr 
    1760                 1765                 1770             


Gly Pro  Leu Ile Asp Met Ser  Asp Ile Arg Pro Gly  Thr Asn Pro 
    1775                 1780                 1785             


Val Ser  Arg Lys Asn Val Lys  Ser Ala His Ser Thr  Arg Asn Arg 
    1790                 1795                 1800             


Tyr Ser  Ser Gln Trp Thr Leu  Thr Lys Cys Gln Ala  Ser Thr Pro 
    1805                 1810                 1815             


Ala Arg  Thr Leu Thr Ser Asp  Trp Arg Thr Val Gly  Ser Gln His 
    1820                 1825                 1830             


Gly Val  Thr Val Thr Glu Ser  Asp Ser Tyr Ser Ala  Ser Leu Ser 
    1835                 1840                 1845             


Gln Asp  Thr Asp Lys Gly Arg  Asn Ser Met Val Ser  Thr Glu Ser 
    1850                 1855                 1860             


Ala Ser  Ser Thr Tyr Glu Glu  Leu Ala Arg Ala Tyr  Glu His Ala 
    1865                 1870                 1875             


Lys Leu  Glu Glu Gln Leu Gln  His Ala Lys Phe Glu  Ile Thr Glu 
    1880                 1885                 1890             


Cys Phe  Ile Ser Asp Ser Ser  Ser Asp Gln Met Thr  Thr Gly Thr 
    1895                 1900                 1905             


Asn Glu  Asn Ala Asp Ser Met  Thr Ser Met Ser Thr  Pro Ser Glu 
    1910                 1915                 1920             


Pro Gly  Ile Cys Arg Phe Thr  Ala Ser Pro Pro Lys  Pro Gln Asp 
    1925                 1930                 1935             


Ala Asp  Arg Gly Lys Asn Val  Ala Val Pro Ile Pro  His Arg Ala 
    1940                 1945                 1950             


Asn Lys  Ser Asp Tyr Cys Asn  Leu Pro Leu Tyr Ala  Lys Ser Glu 
    1955                 1960                 1965             


Ala Phe  Phe Arg Lys Ala Asp  Gly Arg Glu Pro Cys  Pro Val Val 
    1970                 1975                 1980             


Pro Pro  Arg Glu Ala Ser Ile  Arg Asn Leu Ala Arg  Thr Tyr His 
    1985                 1990                 1995             


Thr Gln  Ala Arg His Leu Thr  Leu Asp Pro Ala Ser  Lys Ser Leu 
    2000                 2005                 2010             


Gly Leu  Pro His Pro Gly Ala  Pro Ala Ala Ala Ser  Thr Ala Thr 
    2015                 2020                 2025             


Leu Pro  Gln Arg Thr Leu Ala  Met Pro Ala Pro Pro  Ala Gly Thr 
    2030                 2035                 2040             


Ala Pro  Pro Ala Pro Gly Pro  Thr Pro Ala Glu Pro  Pro Thr Ala 
    2045                 2050                 2055             


Pro Ser  Ala Ala Pro Pro Ala  Pro Ser Thr Glu Pro  Pro Arg Ala 
    2060                 2065                 2070             


Gly Gly  Pro His Thr Lys Met  Gly Gly Ser Arg Asp  Ser Leu Leu 
    2075                 2080                 2085             


Glu Met  Ser Thr Ser Gly Val  Gly Arg Ser Gln Lys  Gln Gly Ala 
    2090                 2095                 2100             


Gly Ala  Tyr Ser Lys Ser Tyr  Thr Leu Val 
    2105                 2110             


<210>  3274
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSCC1__Homo_sapiens__NP_076999

<400>  3274

Met Lys Arg Thr Arg Asp Glu Val Asp Ala Thr Leu Gln Ile Ala Lys 
1               5                   10                  15      


Leu Asn Ala Ala Glu Leu Leu Pro Ala Val His Cys Leu Gly Phe Gly 
            20                  25                  30          


Pro Gly Ala Ser Gly Ala Ala Ala Gly Asp Phe Cys Leu Leu Glu Leu 
        35                  40                  45              


Glu Pro Thr Leu Cys Gln Gln Leu Glu Asp Gly His Ser Leu Val Ile 
    50                  55                  60                  


Arg Gly Asp Lys Asp Glu Gln Ala Val Leu Cys Ser Lys Asp Lys Thr 
65                  70                  75                  80  


Tyr Asp Leu Lys Ile Ala Asp Thr Ser Asn Met Leu Leu Phe Ile Pro 
                85                  90                  95      


Gly Cys Lys Thr Pro Asp Gln Leu Lys Lys Glu Asp Ser His Cys Asn 
            100                 105                 110         


Ile Ile His Thr Glu Ile Phe Gly Phe Ser Asn Asn Tyr Trp Glu Leu 
        115                 120                 125             


Arg Arg Arg Arg Pro Lys Leu Lys Lys Leu Lys Lys Leu Leu Met Glu 
    130                 135                 140                 


Asn Pro Tyr Glu Gly Pro Asp Ser Gln Lys Glu Lys Asp Ser Asn Ser 
145                 150                 155                 160 


Ser Lys Tyr Thr Thr Glu Asp Leu Leu Asp Gln Ile Gln Ala Ser Glu 
                165                 170                 175     


Glu Glu Ile Met Thr Gln Leu Gln Val Leu Asn Ala Cys Lys Ile Gly 
            180                 185                 190         


Gly Tyr Trp Arg Ile Leu Glu Phe Asp Tyr Glu Met Lys Leu Leu Asn 
        195                 200                 205             


His Val Thr Gln Leu Val Asp Ser Glu Ser Trp Ser Phe Gly Lys Val 
    210                 215                 220                 


Pro Leu Asn Thr Cys Leu Gln Glu Leu Gly Pro Leu Glu Pro Glu Glu 
225                 230                 235                 240 


Met Ile Glu His Cys Leu Lys Cys Tyr Gly Lys Lys Tyr Val Asp Glu 
                245                 250                 255     


Gly Glu Val Tyr Phe Glu Leu Asp Ala Asp Lys Ile Cys Arg Ala Ala 
            260                 265                 270         


Ala Arg Met Leu Leu Gln Asn Ala Val Lys Phe Asn Leu Ala Glu Phe 
        275                 280                 285             


Gln Glu Val Trp Gln Gln Ser Val Pro Glu Gly Met Val Thr Ser Leu 
    290                 295                 300                 


Asp Gln Leu Lys Gly Leu Ala Leu Val Asp Arg His Ser Arg Pro Glu 
305                 310                 315                 320 


Ile Ile Phe Leu Leu Lys Val Asp Asp Leu Pro Glu Asp Asn Gln Glu 
                325                 330                 335     


Arg Phe Asn Ser Leu Phe Ser Leu Arg Glu Lys Trp Thr Glu Glu Asp 
            340                 345                 350         


Ile Ala Pro Tyr Ile Gln Asp Leu Cys Gly Glu Lys Gln Thr Ile Gly 
        355                 360                 365             


Ala Leu Leu Thr Lys Tyr Ser His Ser Ser Met Gln Asn Gly Val Lys 
    370                 375                 380                 


Val Tyr Asn Ser Arg Arg Pro Ile Ser 
385                 390             


<210>  3275
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSCR4__Homo_sapiens__NP_005858

<400>  3275

Met Ser Leu Ile Ile Leu Thr Arg Asp Asp Glu Pro Arg Ile Phe Thr 
1               5                   10                  15      


Pro Asp Ser Asp Ala Ala Ser Pro Ala Leu His Ser Thr Ser Pro Leu 
            20                  25                  30          


Pro Asp Pro Ala Ser Ala Ser Pro Leu His Arg Glu Glu Lys Ile Leu 
        35                  40                  45              


Pro Lys Val Cys Asn Ile Val Ser Cys Leu Ser Phe Ser Leu Pro Ala 
    50                  55                  60                  


Ser Pro Thr Asp Ser Gly Leu Ala Ser Pro Thr Ile Ile Thr Arg Glu 
65                  70                  75                  80  


Gly Gln Gln Phe Trp Ala Lys Cys Leu Ile Trp Lys Tyr Gln Leu Tyr 
                85                  90                  95      


Leu His Gly Leu His Lys Lys Ser Asp Gly Arg Arg Asp Lys Gln Ile 
            100                 105                 110         


Ser Ala Ser Pro Ser Thr 
        115             


<210>  3276
<211>  958
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSE__Homo_sapiens__NP_037484

<400>  3276

Met Arg Thr His Thr Arg Gly Ala Pro Ser Val Phe Phe Ile Tyr Leu 
1               5                   10                  15      


Leu Cys Phe Val Ser Ala Tyr Ile Thr Asp Glu Asn Pro Glu Val Met 
            20                  25                  30          


Ile Pro Phe Thr Asn Ala Asn Tyr Asp Ser His Pro Met Leu Tyr Phe 
        35                  40                  45              


Ser Arg Ala Glu Val Ala Glu Leu Gln Leu Arg Ala Ala Ser Ser His 
    50                  55                  60                  


Glu His Ile Ala Ala Arg Leu Thr Glu Ala Val His Thr Met Leu Ser 
65                  70                  75                  80  


Ser Pro Leu Glu Tyr Leu Pro Pro Trp Asp Pro Lys Asp Tyr Ser Ala 
                85                  90                  95      


Arg Trp Asn Glu Ile Phe Gly Asn Asn Leu Gly Ala Leu Ala Met Phe 
            100                 105                 110         


Cys Val Leu Tyr Pro Glu Asn Ile Glu Ala Arg Asp Met Ala Lys Asp 
        115                 120                 125             


Tyr Met Glu Arg Met Ala Ala Gln Pro Ser Trp Leu Val Lys Asp Ala 
    130                 135                 140                 


Pro Trp Asp Glu Val Pro Leu Ala His Ser Leu Val Gly Phe Ala Thr 
145                 150                 155                 160 


Ala Tyr Asp Phe Leu Tyr Asn Tyr Leu Ser Lys Thr Gln Gln Glu Lys 
                165                 170                 175     


Phe Leu Glu Val Ile Ala Asn Ala Ser Gly Tyr Met Tyr Glu Thr Ser 
            180                 185                 190         


Tyr Arg Arg Gly Trp Gly Phe Gln Tyr Leu His Asn His Gln Pro Thr 
        195                 200                 205             


Asn Cys Met Ala Leu Leu Thr Gly Ser Leu Val Leu Met Asn Gln Gly 
    210                 215                 220                 


Tyr Leu Gln Glu Ala Tyr Leu Trp Thr Lys Gln Val Leu Thr Ile Met 
225                 230                 235                 240 


Glu Lys Ser Leu Val Leu Leu Arg Glu Val Thr Asp Gly Ser Leu Tyr 
                245                 250                 255     


Glu Gly Val Ala Tyr Gly Ser Tyr Thr Thr Arg Ser Leu Phe Gln Tyr 
            260                 265                 270         


Met Phe Leu Val Gln Arg His Phe Asn Ile Asn His Phe Gly His Pro 
        275                 280                 285             


Trp Leu Lys Gln His Phe Ala Phe Met Tyr Arg Thr Ile Leu Pro Gly 
    290                 295                 300                 


Phe Gln Arg Thr Val Ala Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr 
305                 310                 315                 320 


Gly Pro Glu Ser Gln Leu Val Phe Leu Asp Lys Phe Val Met Arg Asn 
                325                 330                 335     


Gly Ser Gly Asn Trp Leu Ala Asp Gln Ile Arg Arg Asn Arg Val Val 
            340                 345                 350         


Glu Gly Pro Gly Thr Pro Ser Lys Gly Gln Arg Trp Cys Thr Leu His 
        355                 360                 365             


Thr Glu Phe Leu Trp Tyr Asp Gly Ser Leu Lys Ser Val Pro Pro Pro 
    370                 375                 380                 


Asp Phe Gly Thr Pro Thr Leu His Tyr Phe Glu Asp Trp Gly Val Val 
385                 390                 395                 400 


Thr Tyr Gly Ser Ala Leu Pro Ala Glu Ile Asn Arg Ser Phe Leu Ser 
                405                 410                 415     


Phe Lys Ser Gly Lys Leu Gly Gly Arg Ala Ile Tyr Asp Ile Val His 
            420                 425                 430         


Arg Asn Lys Tyr Lys Asp Trp Ile Lys Gly Trp Arg Asn Phe Asn Ala 
        435                 440                 445             


Gly His Glu His Pro Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly 
    450                 455                 460                 


Val Pro Phe Ile Thr Glu Ala Leu Tyr Gly Pro Lys Tyr Thr Phe Phe 
465                 470                 475                 480 


Asn Asn Val Leu Met Phe Ser Pro Ala Val Ser Lys Ser Cys Phe Ser 
                485                 490                 495     


Pro Trp Val Gly Gln Val Thr Glu Asp Cys Ser Ser Lys Trp Ser Lys 
            500                 505                 510         


Tyr Lys His Asp Leu Ala Ala Ser Cys Gln Gly Arg Val Val Ala Ala 
        515                 520                 525             


Glu Glu Lys Asn Gly Val Val Phe Ile Arg Gly Glu Gly Val Gly Ala 
    530                 535                 540                 


Tyr Asn Pro Gln Leu Asn Leu Lys Asn Val Gln Arg Asn Leu Ile Leu 
545                 550                 555                 560 


Leu His Pro Gln Leu Leu Leu Leu Val Asp Gln Ile His Leu Gly Glu 
                565                 570                 575     


Glu Ser Pro Leu Glu Thr Ala Ala Ser Phe Phe His Asn Val Asp Val 
            580                 585                 590         


Pro Phe Glu Glu Thr Val Val Asp Gly Val His Gly Ala Phe Ile Arg 
        595                 600                 605             


Gln Arg Asp Gly Leu Tyr Lys Met Tyr Trp Met Asp Asp Thr Gly Tyr 
    610                 615                 620                 


Ser Glu Lys Ala Thr Phe Ala Ser Val Thr Tyr Pro Arg Gly Tyr Pro 
625                 630                 635                 640 


Tyr Asn Gly Thr Asn Tyr Val Asn Val Thr Met His Leu Arg Ser Pro 
                645                 650                 655     


Ile Thr Arg Ala Ala Tyr Leu Phe Ile Gly Pro Ser Ile Asp Val Gln 
            660                 665                 670         


Ser Phe Thr Val His Gly Asp Ser Gln Gln Leu Asp Val Phe Ile Ala 
        675                 680                 685             


Thr Ser Lys His Ala Tyr Ala Thr Tyr Leu Trp Thr Gly Glu Ala Thr 
    690                 695                 700                 


Gly Gln Ser Ala Phe Ala Gln Val Ile Ala Asp Arg His Lys Ile Leu 
705                 710                 715                 720 


Phe Asp Arg Asn Ser Ala Ile Lys Ser Ser Ile Val Pro Glu Val Lys 
                725                 730                 735     


Asp Tyr Ala Ala Ile Val Glu Gln Asn Leu Gln His Phe Lys Pro Val 
            740                 745                 750         


Phe Gln Leu Leu Glu Lys Gln Ile Leu Ser Arg Val Arg Asn Thr Ala 
        755                 760                 765             


Ser Phe Arg Lys Thr Ala Glu Arg Leu Leu Arg Phe Ser Asp Lys Arg 
    770                 775                 780                 


Gln Thr Glu Glu Ala Ile Asp Arg Ile Phe Ala Ile Ser Gln Gln Gln 
785                 790                 795                 800 


Gln Gln Gln Ser Lys Ser Lys Lys Asn Arg Arg Ala Gly Lys Arg Tyr 
                805                 810                 815     


Lys Phe Val Asp Ala Val Pro Asp Ile Phe Ala Gln Ile Glu Val Asn 
            820                 825                 830         


Glu Lys Lys Ile Arg Gln Lys Ala Gln Ile Leu Ala Gln Lys Glu Leu 
        835                 840                 845             


Pro Ile Asp Glu Asp Glu Glu Met Lys Asp Leu Leu Asp Phe Ala Asp 
    850                 855                 860                 


Val Thr Tyr Glu Lys His Lys Asn Gly Gly Leu Ile Lys Gly Arg Phe 
865                 870                 875                 880 


Gly Gln Ala Arg Met Val Thr Thr Thr His Ser Arg Ala Pro Ser Leu 
                885                 890                 895     


Ser Ala Ser Tyr Thr Arg Leu Phe Leu Ile Leu Asn Ile Ala Ile Phe 
            900                 905                 910         


Phe Val Met Leu Ala Met Gln Leu Thr Tyr Phe Gln Arg Ala Gln Ser 
        915                 920                 925             


Leu His Gly Gln Arg Cys Leu Tyr Ala Val Leu Leu Ile Asp Ser Cys 
    930                 935                 940                 


Ile Leu Leu Trp Leu Tyr Ser Ser Cys Ser Gln Ser Gln Cys 
945                 950                 955             


<210>  3277
<211>  1222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSEL__Homo_sapiens__NP_115536

<400>  3277

Met Pro Lys Gly Gly Ala Pro Pro Trp Ile Met Ala Leu Met Phe Thr 
1               5                   10                  15      


Gly His Leu Leu Phe Leu Ala Leu Leu Met Phe Ala Phe Ser Thr Phe 
            20                  25                  30          


Glu Glu Ser Val Ser Asn Tyr Ser Glu Trp Ala Val Phe Thr Asp Asp 
        35                  40                  45              


Ile Asp Gln Phe Lys Thr Gln Lys Val Gln Asp Phe Arg Pro Asn Gln 
    50                  55                  60                  


Lys Leu Lys Lys Ser Met Leu His Pro Ser Leu Tyr Phe Asp Ala Gly 
65                  70                  75                  80  


Glu Ile Gln Ala Met Arg Gln Lys Ser Arg Ala Ser His Leu His Leu 
                85                  90                  95      


Phe Arg Ala Ile Arg Ser Ala Val Thr Val Met Leu Ser Asn Pro Thr 
            100                 105                 110         


Tyr Tyr Leu Pro Pro Pro Lys His Ala Asp Phe Ala Ala Lys Trp Asn 
        115                 120                 125             


Glu Ile Tyr Gly Asn Asn Leu Pro Pro Leu Ala Leu Tyr Cys Leu Leu 
    130                 135                 140                 


Cys Pro Glu Asp Lys Val Ala Phe Glu Phe Val Leu Glu Tyr Met Asp 
145                 150                 155                 160 


Arg Met Val Gly Tyr Lys Asp Trp Leu Val Glu Asn Ala Pro Gly Asp 
                165                 170                 175     


Glu Val Pro Ile Gly His Ser Leu Thr Gly Phe Ala Thr Ala Phe Asp 
            180                 185                 190         


Phe Leu Tyr Asn Leu Leu Asp Asn His Arg Arg Gln Lys Tyr Leu Glu 
        195                 200                 205             


Lys Ile Trp Val Ile Thr Glu Glu Met Tyr Glu Tyr Ser Lys Val Arg 
    210                 215                 220                 


Ser Trp Gly Lys Gln Leu Leu His Asn His Gln Ala Thr Asn Met Ile 
225                 230                 235                 240 


Ala Leu Leu Thr Gly Ala Leu Val Thr Gly Val Asp Lys Gly Ser Lys 
                245                 250                 255     


Ala Asn Ile Trp Lys Gln Ala Val Val Asp Val Met Glu Lys Thr Met 
            260                 265                 270         


Phe Leu Leu Asn His Ile Val Asp Gly Ser Leu Asp Glu Gly Val Ala 
        275                 280                 285             


Tyr Gly Ser Tyr Thr Ala Lys Ser Val Thr Gln Tyr Val Phe Leu Ala 
    290                 295                 300                 


Gln Arg His Phe Asn Ile Asn Asn Leu Asp Asn Asn Trp Leu Lys Met 
305                 310                 315                 320 


His Phe Trp Phe Tyr Tyr Ala Thr Leu Leu Pro Gly Phe Gln Arg Thr 
                325                 330                 335     


Val Gly Ile Ala Asp Ser Asn Tyr Asn Trp Phe Tyr Gly Pro Glu Ser 
            340                 345                 350         


Gln Leu Val Phe Leu Asp Lys Phe Ile Leu Lys Asn Gly Ala Gly Asn 
        355                 360                 365             


Trp Leu Ala Gln Gln Ile Arg Lys His Arg Pro Lys Asp Gly Pro Met 
    370                 375                 380                 


Val Pro Ser Thr Ala Gln Arg Trp Ser Thr Leu His Thr Glu Tyr Ile 
385                 390                 395                 400 


Trp Tyr Asp Pro Gln Leu Thr Pro Gln Pro Pro Ala Asp Tyr Gly Thr 
                405                 410                 415     


Ala Lys Ile His Thr Phe Pro Asn Trp Gly Val Val Thr Tyr Gly Ala 
            420                 425                 430         


Gly Leu Pro Asn Thr Gln Thr Asn Thr Phe Val Ser Phe Lys Ser Gly 
        435                 440                 445             


Lys Leu Gly Gly Arg Ala Val Tyr Asp Ile Val His Phe Gln Pro Tyr 
    450                 455                 460                 


Ser Trp Ile Asp Gly Trp Arg Ser Phe Asn Pro Gly His Glu His Pro 
465                 470                 475                 480 


Asp Gln Asn Ser Phe Thr Phe Ala Pro Asn Gly Gln Val Phe Val Ser 
                485                 490                 495     


Glu Ala Leu Tyr Gly Pro Lys Leu Ser His Leu Asn Asn Val Leu Val 
            500                 505                 510         


Phe Ala Pro Ser Pro Ser Ser Gln Cys Asn Lys Pro Trp Glu Gly Gln 
        515                 520                 525             


Leu Gly Glu Cys Ala Gln Trp Leu Lys Trp Thr Gly Glu Glu Val Gly 
    530                 535                 540                 


Asp Ala Ala Gly Glu Ile Ile Thr Ala Ser Gln His Gly Glu Met Val 
545                 550                 555                 560 


Phe Val Ser Gly Glu Ala Val Ser Ala Tyr Ser Ser Ala Met Arg Leu 
                565                 570                 575     


Lys Ser Val Tyr Arg Ala Leu Leu Leu Leu Asn Ser Gln Thr Leu Leu 
            580                 585                 590         


Val Val Asp His Ile Glu Arg Gln Glu Asp Ser Pro Ile Asn Ser Val 
        595                 600                 605             


Ser Ala Phe Phe His Asn Leu Asp Ile Asp Phe Lys Tyr Ile Pro Tyr 
    610                 615                 620                 


Lys Phe Met Asn Arg Tyr Asn Gly Ala Met Met Asp Val Trp Asp Ala 
625                 630                 635                 640 


His Tyr Lys Met Phe Trp Phe Asp His His Gly Asn Ser Pro Met Ala 
                645                 650                 655     


Ser Ile Gln Glu Ala Glu Gln Ala Ala Glu Phe Lys Lys Arg Trp Thr 
            660                 665                 670         


Gln Phe Val Asn Val Thr Phe Gln Met Glu Pro Thr Ile Thr Arg Ile 
        675                 680                 685             


Ala Tyr Val Phe Tyr Gly Pro Tyr Ile Asn Val Ser Ser Cys Arg Phe 
    690                 695                 700                 


Ile Asp Ser Ser Asn Pro Gly Leu Gln Ile Ser Leu Asn Val Asn Asn 
705                 710                 715                 720 


Thr Glu His Val Val Ser Ile Val Thr Asp Tyr His Asn Leu Lys Thr 
                725                 730                 735     


Arg Phe Asn Tyr Leu Gly Phe Gly Gly Phe Ala Ser Val Ala Asp Gln 
            740                 745                 750         


Gly Gln Ile Thr Arg Phe Gly Leu Gly Thr Gln Ala Ile Val Lys Pro 
        755                 760                 765             


Val Arg His Asp Arg Ile Ile Phe Pro Phe Gly Phe Lys Phe Asn Ile 
    770                 775                 780                 


Ala Val Gly Leu Ile Leu Cys Ile Ser Leu Val Ile Leu Thr Phe Gln 
785                 790                 795                 800 


Trp Arg Phe Tyr Leu Ser Phe Arg Lys Leu Met Arg Trp Ile Leu Ile 
                805                 810                 815     


Leu Val Ile Ala Leu Trp Phe Ile Glu Leu Leu Asp Val Trp Ser Thr 
            820                 825                 830         


Cys Ser Gln Pro Ile Cys Ala Lys Trp Thr Arg Thr Glu Ala Glu Gly 
        835                 840                 845             


Ser Lys Lys Ser Leu Ser Ser Glu Gly His His Met Asp Leu Pro Asp 
    850                 855                 860                 


Val Val Ile Thr Ser Leu Pro Gly Ser Gly Ala Glu Ile Leu Lys Gln 
865                 870                 875                 880 


Leu Phe Phe Asn Ser Ser Asp Phe Leu Tyr Ile Arg Val Pro Thr Ala 
                885                 890                 895     


Tyr Ile Asp Ile Pro Glu Thr Glu Leu Glu Ile Asp Ser Phe Val Asp 
            900                 905                 910         


Ala Cys Glu Trp Lys Val Ser Asp Ile Arg Ser Gly His Phe Arg Leu 
        915                 920                 925             


Leu Arg Gly Trp Leu Gln Ser Leu Val Gln Asp Thr Lys Leu His Leu 
    930                 935                 940                 


Gln Asn Ile His Leu His Glu Pro Asn Arg Gly Lys Leu Ala Gln Tyr 
945                 950                 955                 960 


Phe Ala Met Asn Lys Asp Lys Lys Arg Lys Phe Lys Arg Arg Glu Ser 
                965                 970                 975     


Leu Pro Glu Gln Arg Ser Gln Met Lys Gly Ala Phe Asp Arg Asp Ala 
            980                 985                 990         


Glu Tyr Ile Arg Ala Leu Arg Arg  His Leu Val Tyr Tyr  Pro Ser Ala 
        995                 1000                 1005             


Arg Pro  Val Leu Ser Leu Ser  Ser Gly Ser Trp Thr  Leu Lys Leu 
    1010                 1015                 1020             


His Phe  Phe Gln Glu Val Leu  Gly Ala Ser Met Arg  Ala Leu Tyr 
    1025                 1030                 1035             


Ile Val  Arg Asp Pro Arg Ala  Trp Ile Tyr Ser Met  Leu Tyr Asn 
    1040                 1045                 1050             


Ser Lys  Pro Ser Leu Tyr Ser  Leu Lys Asn Val Pro  Glu His Leu 
    1055                 1060                 1065             


Ala Lys  Leu Phe Lys Ile Glu  Gly Gly Lys Gly Lys  Cys Asn Leu 
    1070                 1075                 1080             


Asn Ser  Gly Tyr Ala Phe Glu  Tyr Glu Pro Leu Arg  Lys Glu Leu 
    1085                 1090                 1095             


Ser Lys  Ser Lys Ser Asn Ala  Val Ser Leu Leu Ser  His Leu Trp 
    1100                 1105                 1110             


Leu Ala  Asn Thr Ala Ala Ala  Leu Arg Ile Asn Thr  Asp Leu Leu 
    1115                 1120                 1125             


Pro Thr  Ser Tyr Gln Leu Val  Lys Phe Glu Asp Ile  Val His Phe 
    1130                 1135                 1140             


Pro Gln  Lys Thr Thr Glu Arg  Ile Phe Ala Phe Leu  Gly Ile Pro 
    1145                 1150                 1155             


Leu Ser  Pro Ala Ser Leu Asn  Gln Ile Leu Phe Ala  Thr Ser Thr 
    1160                 1165                 1170             


Asn Leu  Phe Tyr Leu Pro Tyr  Glu Gly Glu Ile Ser  Pro Thr Asn 
    1175                 1180                 1185             


Thr Asn  Val Trp Lys Gln Asn  Leu Pro Arg Asp Glu  Ile Lys Leu 
    1190                 1195                 1200             


Ile Glu  Asn Ile Cys Trp Thr  Leu Met Asp Arg Leu  Gly Tyr Pro 
    1205                 1210                 1215             


Lys Phe  Met Asp 
    1220         


<210>  3278
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSG1__Homo_sapiens__NP_001933

<400>  3278

Met Asp Trp Ser Phe Phe Arg Val Val Ala Met Leu Phe Ile Phe Leu 
1               5                   10                  15      


Val Val Val Glu Val Asn Ser Glu Phe Arg Ile Gln Val Arg Asp Tyr 
            20                  25                  30          


Asn Thr Lys Asn Gly Thr Ile Lys Trp His Ser Ile Arg Arg Gln Lys 
        35                  40                  45              


Arg Glu Trp Ile Lys Phe Ala Ala Ala Cys Arg Glu Gly Glu Asp Asn 
    50                  55                  60                  


Ser Lys Arg Asn Pro Ile Ala Lys Ile His Ser Asp Cys Ala Ala Asn 
65                  70                  75                  80  


Gln Gln Val Thr Tyr Arg Ile Ser Gly Val Gly Ile Asp Gln Pro Pro 
                85                  90                  95      


Tyr Gly Ile Phe Val Ile Asn Gln Lys Thr Gly Glu Ile Asn Ile Thr 
            100                 105                 110         


Ser Ile Val Asp Arg Glu Val Thr Pro Phe Phe Ile Ile Tyr Cys Arg 
        115                 120                 125             


Ala Leu Asn Ser Met Gly Gln Asp Leu Glu Arg Pro Leu Glu Leu Arg 
    130                 135                 140                 


Val Arg Val Leu Asp Ile Asn Asp Asn Pro Pro Val Phe Ser Met Ala 
145                 150                 155                 160 


Thr Phe Ala Gly Gln Ile Glu Glu Asn Ser Asn Ala Asn Thr Leu Val 
                165                 170                 175     


Met Ile Leu Asn Ala Thr Asp Ala Asp Glu Pro Asn Asn Leu Asn Ser 
            180                 185                 190         


Lys Ile Ala Phe Lys Ile Ile Arg Gln Glu Pro Ser Asp Ser Pro Met 
        195                 200                 205             


Phe Ile Ile Asn Arg Asn Thr Gly Glu Ile Arg Thr Met Asn Asn Phe 
    210                 215                 220                 


Leu Asp Arg Glu Gln Tyr Gly Gln Tyr Ala Leu Ala Val Arg Gly Ser 
225                 230                 235                 240 


Asp Arg Asp Gly Gly Ala Asp Gly Met Ser Ala Glu Cys Glu Cys Asn 
                245                 250                 255     


Ile Lys Ile Leu Asp Val Asn Asp Asn Ile Pro Tyr Met Glu Gln Ser 
            260                 265                 270         


Ser Tyr Thr Ile Glu Ile Gln Glu Asn Thr Leu Asn Ser Asn Leu Leu 
        275                 280                 285             


Glu Ile Arg Val Ile Asp Leu Asp Glu Glu Phe Ser Ala Asn Trp Met 
    290                 295                 300                 


Ala Val Ile Phe Phe Ile Ser Gly Asn Glu Gly Asn Trp Phe Glu Ile 
305                 310                 315                 320 


Glu Met Asn Glu Arg Thr Asn Val Gly Ile Leu Lys Val Val Lys Pro 
                325                 330                 335     


Leu Asp Tyr Glu Ala Met Gln Ser Leu Gln Leu Ser Ile Gly Val Arg 
            340                 345                 350         


Asn Lys Ala Glu Phe His His Ser Ile Met Ser Gln Tyr Lys Leu Lys 
        355                 360                 365             


Ala Ser Ala Ile Ser Val Thr Val Leu Asn Val Ile Glu Gly Pro Val 
    370                 375                 380                 


Phe Arg Pro Gly Ser Lys Thr Tyr Val Val Thr Gly Asn Met Gly Ser 
385                 390                 395                 400 


Asn Asp Lys Val Gly Asp Phe Val Ala Thr Asp Leu Asp Thr Gly Arg 
                405                 410                 415     


Pro Ser Thr Thr Val Arg Tyr Val Met Gly Asn Asn Pro Ala Asp Leu 
            420                 425                 430         


Leu Ala Val Asp Ser Arg Thr Gly Lys Leu Thr Leu Lys Asn Lys Val 
        435                 440                 445             


Thr Lys Glu Gln Tyr Asn Met Leu Gly Gly Lys Tyr Gln Gly Thr Ile 
    450                 455                 460                 


Leu Ser Ile Asp Asp Asn Leu Gln Arg Thr Cys Thr Gly Thr Ile Asn 
465                 470                 475                 480 


Ile Asn Ile Gln Ser Phe Gly Asn Asp Asp Arg Thr Asn Thr Glu Pro 
                485                 490                 495     


Asn Thr Lys Ile Thr Thr Asn Thr Gly Arg Gln Glu Ser Thr Ser Ser 
            500                 505                 510         


Thr Asn Tyr Asp Thr Ser Thr Thr Ser Thr Asp Ser Ser Gln Val Tyr 
        515                 520                 525             


Ser Ser Glu Pro Gly Asn Gly Ala Lys Asp Leu Leu Ser Asp Asn Val 
    530                 535                 540                 


His Phe Gly Pro Ala Gly Ile Gly Leu Leu Ile Met Gly Phe Leu Val 
545                 550                 555                 560 


Leu Gly Leu Val Pro Phe Leu Met Ile Cys Cys Asp Cys Gly Gly Ala 
                565                 570                 575     


Pro Arg Ser Ala Ala Gly Phe Glu Pro Val Pro Glu Cys Ser Asp Gly 
            580                 585                 590         


Ala Ile His Ser Trp Ala Val Glu Gly Pro Gln Pro Glu Pro Arg Asp 
        595                 600                 605             


Ile Thr Thr Val Ile Pro Gln Ile Pro Pro Asp Asn Ala Asn Ile Ile 
    610                 615                 620                 


Glu Cys Ile Asp Asn Ser Gly Val Tyr Thr Asn Glu Tyr Gly Gly Arg 
625                 630                 635                 640 


Glu Met Gln Asp Leu Gly Gly Gly Glu Arg Met Thr Gly Phe Glu Leu 
                645                 650                 655     


Thr Glu Gly Val Lys Thr Ser Gly Met Pro Glu Ile Cys Gln Glu Tyr 
            660                 665                 670         


Ser Gly Thr Leu Arg Arg Asn Ser Met Arg Glu Cys Arg Glu Gly Gly 
        675                 680                 685             


Leu Asn Met Asn Phe Met Glu Ser Tyr Phe Cys Gln Lys Ala Tyr Ala 
    690                 695                 700                 


Tyr Ala Asp Glu Asp Glu Gly Arg Pro Ser Asn Asp Cys Leu Leu Ile 
705                 710                 715                 720 


Tyr Asp Ile Glu Gly Val Gly Ser Pro Ala Gly Ser Val Gly Cys Cys 
                725                 730                 735     


Ser Phe Ile Gly Glu Asp Leu Asp Asp Ser Phe Leu Asp Thr Leu Gly 
            740                 745                 750         


Pro Lys Phe Lys Lys Leu Ala Asp Ile Ser Leu Gly Lys Glu Ser Tyr 
        755                 760                 765             


Pro Asp Leu Asp Pro Ser Trp Pro Pro Gln Ser Thr Glu Pro Val Cys 
    770                 775                 780                 


Leu Pro Gln Glu Thr Glu Pro Val Val Ser Gly His Pro Pro Ile Ser 
785                 790                 795                 800 


Pro His Phe Gly Thr Thr Thr Val Ile Ser Glu Ser Thr Tyr Pro Ser 
                805                 810                 815     


Gly Pro Gly Val Leu His Pro Lys Pro Ile Leu Asp Pro Leu Gly Tyr 
            820                 825                 830         


Gly Asn Val Thr Val Thr Glu Ser Tyr Thr Thr Ser Asp Thr Leu Lys 
        835                 840                 845             


Pro Ser Val His Val His Asp Asn Arg Pro Ala Ser Asn Val Val Val 
    850                 855                 860                 


Thr Glu Arg Val Val Gly Pro Ile Ser Gly Ala Asp Leu His Gly Met 
865                 870                 875                 880 


Leu Glu Met Pro Asp Leu Arg Asp Gly Ser Asn Val Ile Val Thr Glu 
                885                 890                 895     


Arg Val Ile Ala Pro Ser Ser Ser Leu Pro Thr Ser Leu Thr Ile His 
            900                 905                 910         


His Pro Arg Glu Ser Ser Asn Val Val Val Thr Glu Arg Val Ile Gln 
        915                 920                 925             


Pro Thr Ser Gly Met Ile Gly Ser Leu Ser Met His Pro Glu Leu Ala 
    930                 935                 940                 


Asn Ala His Asn Val Ile Val Thr Glu Arg Val Val Ser Gly Ala Gly 
945                 950                 955                 960 


Val Thr Gly Ile Ser Gly Thr Thr Gly Ile Ser Gly Gly Ile Gly Ser 
                965                 970                 975     


Ser Gly Leu Val Gly Thr Ser Met Gly Ala Gly Ser Gly Ala Leu Ser 
            980                 985                 990         


Gly Ala Gly Ile Ser Gly Gly Gly  Ile Gly Leu Ser Ser  Leu Gly Gly 
        995                 1000                 1005             


Thr Ala  Ser Ile Gly His Met  Arg Ser Ser Ser Asp  His His Phe 
    1010                 1015                 1020             


Asn Gln  Thr Ile Gly Ser Ala  Ser Pro Ser Thr Ala  Arg Ser Arg 
    1025                 1030                 1035             


Ile Thr  Lys Tyr Ser Thr Val  Gln Tyr Ser Lys 
    1040                 1045                 


<210>  3279
<211>  1118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSG2__Homo_sapiens__NP_001934

<400>  3279

Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu 
225                 230                 235                 240 


Ala Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala 
                245                 250                 255     


Gln Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val 
            260                 265                 270         


Glu Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val 
        275                 280                 285             


Glu Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp 
    290                 295                 300                 


Asn Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr 
305                 310                 315                 320 


Phe His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu 
                325                 330                 335     


Ile Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val 
            340                 345                 350         


Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr 
        355                 360                 365             


Lys Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu 
    370                 375                 380                 


Gly Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser 
385                 390                 395                 400 


Met Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe 
                405                 410                 415     


Asp Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu 
            420                 425                 430         


Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys 
        435                 440                 445             


Leu Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr 
    450                 455                 460                 


Tyr Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr 
465                 470                 475                 480 


Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys 
                485                 490                 495     


Pro Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr 
            500                 505                 510         


Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro 
        515                 520                 525             


Phe Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp 
    530                 535                 540                 


Lys Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu 
545                 550                 555                 560 


Lys Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln 
                565                 570                 575     


Gly Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu 
            580                 585                 590         


Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val 
        595                 600                 605             


Gly Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu 
    610                 615                 620                 


Leu Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly 
625                 630                 635                 640 


Ala Lys Gly Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro 
                645                 650                 655     


Trp Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe 
            660                 665                 670         


Leu Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly 
        675                 680                 685             


Gly Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile 
    690                 695                 700                 


Val Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu 
705                 710                 715                 720 


His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr 
                725                 730                 735     


Gly Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly 
            740                 745                 750         


Ala Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn 
        755                 760                 765             


Glu Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr 
    770                 775                 780                 


Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser 
785                 790                 795                 800 


Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe 
                805                 810                 815     


Ile Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys 
            820                 825                 830         


Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn 
        835                 840                 845             


Lys Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn 
    850                 855                 860                 


Thr Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn 
865                 870                 875                 880 


Thr Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu 
                885                 890                 895     


Ala Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val 
            900                 905                 910         


Ser Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met 
        915                 920                 925             


Ala Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser 
    930                 935                 940                 


Thr Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser 
945                 950                 955                 960 


Leu Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp 
                965                 970                 975     


Gln Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile 
            980                 985                 990         


Gln Pro His Gly Gly Gly Ser Asn  Pro Leu Glu Gly Thr  Gln His Leu 
        995                 1000                 1005             


Gln Asp  Val Pro Tyr Val Met  Val Arg Glu Arg Glu  Ser Phe Leu 
    1010                 1015                 1020             


Ala Pro  Ser Ser Gly Val Gln  Pro Thr Leu Ala Met  Pro Asn Ile 
    1025                 1030                 1035             


Ala Val  Gly Gln Asn Val Thr  Val Thr Glu Arg Val  Leu Ala Pro 
    1040                 1045                 1050             


Ala Ser  Thr Leu Gln Ser Ser  Tyr Gln Ile Pro Thr  Glu Asn Ser 
    1055                 1060                 1065             


Met Thr  Ala Arg Asn Thr Thr  Val Ser Gly Ala Gly  Val Pro Gly 
    1070                 1075                 1080             


Pro Leu  Pro Asp Phe Gly Leu  Glu Glu Ser Gly His  Ser Asn Ser 
    1085                 1090                 1095             


Thr Ile  Thr Thr Ser Ser Thr  Arg Val Thr Lys His  Ser Thr Val 
    1100                 1105                 1110             


Gln His  Ser Tyr Ser 
    1115             


<210>  3280
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSG3__Homo_sapiens__NP_001935

<400>  3280

Met Met Gly Leu Phe Pro Arg Thr Thr Gly Ala Leu Ala Ile Phe Val 
1               5                   10                  15      


Val Val Ile Leu Val His Gly Glu Leu Arg Ile Glu Thr Lys Gly Gln 
            20                  25                  30          


Tyr Asp Glu Glu Glu Met Thr Met Gln Gln Ala Lys Arg Arg Gln Lys 
        35                  40                  45              


Arg Glu Trp Val Lys Phe Ala Lys Pro Cys Arg Glu Gly Glu Asp Asn 
    50                  55                  60                  


Ser Lys Arg Asn Pro Ile Ala Lys Ile Thr Ser Asp Tyr Gln Ala Thr 
65                  70                  75                  80  


Gln Lys Ile Thr Tyr Arg Ile Ser Gly Val Gly Ile Asp Gln Pro Pro 
                85                  90                  95      


Phe Gly Ile Phe Val Val Asp Lys Asn Thr Gly Asp Ile Asn Ile Thr 
            100                 105                 110         


Ala Ile Val Asp Arg Glu Glu Thr Pro Ser Phe Leu Ile Thr Cys Arg 
        115                 120                 125             


Ala Leu Asn Ala Gln Gly Leu Asp Val Glu Lys Pro Leu Ile Leu Thr 
    130                 135                 140                 


Val Lys Ile Leu Asp Ile Asn Asp Asn Pro Pro Val Phe Ser Gln Gln 
145                 150                 155                 160 


Ile Phe Met Gly Glu Ile Glu Glu Asn Ser Ala Ser Asn Ser Leu Val 
                165                 170                 175     


Met Ile Leu Asn Ala Thr Asp Ala Asp Glu Pro Asn His Leu Asn Ser 
            180                 185                 190         


Lys Ile Ala Phe Lys Ile Val Ser Gln Glu Pro Ala Gly Thr Pro Met 
        195                 200                 205             


Phe Leu Leu Ser Arg Asn Thr Gly Glu Val Arg Thr Leu Thr Asn Ser 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ala Ser Ser Tyr Arg Leu Val Val Ser Gly Ala 
225                 230                 235                 240 


Asp Lys Asp Gly Glu Gly Leu Ser Thr Gln Cys Glu Cys Asn Ile Lys 
                245                 250                 255     


Val Lys Asp Val Asn Asp Asn Phe Pro Met Phe Arg Asp Ser Gln Tyr 
            260                 265                 270         


Ser Ala Arg Ile Glu Glu Asn Ile Leu Ser Ser Glu Leu Leu Arg Phe 
        275                 280                 285             


Gln Val Thr Asp Leu Asp Glu Glu Tyr Thr Asp Asn Trp Leu Ala Val 
    290                 295                 300                 


Tyr Phe Phe Thr Ser Gly Asn Glu Gly Asn Trp Phe Glu Ile Gln Thr 
305                 310                 315                 320 


Asp Pro Arg Thr Asn Glu Gly Ile Leu Lys Val Val Lys Ala Leu Asp 
                325                 330                 335     


Tyr Glu Gln Leu Gln Ser Val Lys Leu Ser Ile Ala Val Lys Asn Lys 
            340                 345                 350         


Ala Glu Phe His Gln Ser Val Ile Ser Arg Tyr Arg Val Gln Ser Thr 
        355                 360                 365             


Pro Val Thr Ile Gln Val Ile Asn Val Arg Glu Gly Ile Ala Phe Arg 
    370                 375                 380                 


Pro Ala Ser Lys Thr Phe Thr Val Gln Lys Gly Ile Ser Ser Lys Lys 
385                 390                 395                 400 


Leu Val Asp Tyr Ile Leu Gly Thr Tyr Gln Ala Ile Asp Glu Asp Thr 
                405                 410                 415     


Asn Lys Ala Ala Ser Asn Val Lys Tyr Val Met Gly Arg Asn Asp Gly 
            420                 425                 430         


Gly Tyr Leu Met Ile Asp Ser Lys Thr Ala Glu Ile Lys Phe Val Lys 
        435                 440                 445             


Asn Met Asn Arg Asp Ser Thr Phe Ile Val Asn Lys Thr Ile Thr Ala 
    450                 455                 460                 


Glu Val Leu Ala Ile Asp Glu Tyr Thr Gly Lys Thr Ser Thr Gly Thr 
465                 470                 475                 480 


Val Tyr Val Arg Val Pro Asp Phe Asn Asp Asn Cys Pro Thr Ala Val 
                485                 490                 495     


Leu Glu Lys Asp Ala Val Cys Ser Ser Ser Pro Ser Val Val Val Ser 
            500                 505                 510         


Ala Arg Thr Leu Asn Asn Arg Tyr Thr Gly Pro Tyr Thr Phe Ala Leu 
        515                 520                 525             


Glu Asp Gln Pro Val Lys Leu Pro Ala Val Trp Ser Ile Thr Thr Leu 
    530                 535                 540                 


Asn Ala Thr Ser Ala Leu Leu Arg Ala Gln Glu Gln Ile Pro Pro Gly 
545                 550                 555                 560 


Val Tyr His Ile Ser Leu Val Leu Thr Asp Ser Gln Asn Asn Arg Cys 
                565                 570                 575     


Glu Met Pro Arg Ser Leu Thr Leu Glu Val Cys Gln Cys Asp Asn Arg 
            580                 585                 590         


Gly Ile Cys Gly Thr Ser Tyr Pro Thr Thr Ser Pro Gly Thr Arg Tyr 
        595                 600                 605             


Gly Arg Pro His Ser Gly Arg Leu Gly Pro Ala Ala Ile Gly Leu Leu 
    610                 615                 620                 


Leu Leu Gly Leu Leu Leu Leu Leu Leu Ala Pro Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Asp Cys Gly Ala Gly Ser Thr Gly Gly Val Thr Gly Gly Phe Ile 
                645                 650                 655     


Pro Val Pro Asp Gly Ser Glu Gly Thr Ile His Gln Trp Gly Ile Glu 
            660                 665                 670         


Gly Ala His Pro Glu Asp Lys Glu Ile Thr Asn Ile Cys Val Pro Pro 
        675                 680                 685             


Val Thr Ala Asn Gly Ala Asp Phe Met Glu Ser Ser Glu Val Cys Thr 
    690                 695                 700                 


Asn Thr Tyr Ala Arg Gly Thr Ala Val Glu Gly Thr Ser Gly Met Glu 
705                 710                 715                 720 


Met Thr Thr Lys Leu Gly Ala Ala Thr Glu Ser Gly Gly Ala Ala Gly 
                725                 730                 735     


Phe Ala Thr Gly Thr Val Ser Gly Ala Ala Ser Gly Phe Gly Ala Ala 
            740                 745                 750         


Thr Gly Val Gly Ile Cys Ser Ser Gly Gln Ser Gly Thr Met Arg Thr 
        755                 760                 765             


Arg His Ser Thr Gly Gly Thr Asn Lys Asp Tyr Ala Asp Gly Ala Ile 
    770                 775                 780                 


Ser Met Asn Phe Leu Asp Ser Tyr Phe Ser Gln Lys Ala Phe Ala Cys 
785                 790                 795                 800 


Ala Glu Glu Asp Asp Gly Gln Glu Ala Asn Asp Cys Leu Leu Ile Tyr 
                805                 810                 815     


Asp Asn Glu Gly Ala Asp Ala Thr Gly Ser Pro Val Gly Ser Val Gly 
            820                 825                 830         


Cys Cys Ser Phe Ile Ala Asp Asp Leu Asp Asp Ser Phe Leu Asp Ser 
        835                 840                 845             


Leu Gly Pro Lys Phe Lys Lys Leu Ala Glu Ile Ser Leu Gly Val Asp 
    850                 855                 860                 


Gly Glu Gly Lys Glu Val Gln Pro Pro Ser Lys Asp Ser Gly Tyr Gly 
865                 870                 875                 880 


Ile Glu Ser Cys Gly His Pro Ile Glu Val Gln Gln Thr Gly Phe Val 
                885                 890                 895     


Lys Cys Gln Thr Leu Ser Gly Ser Gln Gly Ala Ser Ala Leu Ser Thr 
            900                 905                 910         


Ser Gly Ser Val Gln Pro Ala Val Ser Ile Pro Asp Pro Leu Gln His 
        915                 920                 925             


Gly Asn Tyr Leu Val Thr Glu Thr Tyr Ser Ala Ser Gly Ser Leu Val 
    930                 935                 940                 


Gln Pro Ser Thr Ala Gly Phe Asp Pro Leu Leu Thr Gln Asn Val Ile 
945                 950                 955                 960 


Val Thr Glu Arg Val Ile Cys Pro Ile Ser Ser Val Pro Gly Asn Leu 
                965                 970                 975     


Ala Gly Pro Thr Gln Leu Arg Gly Ser His Thr Met Leu Cys Thr Glu 
            980                 985                 990         


Asp Pro Cys Ser Arg Leu Ile 
        995                 


<210>  3281
<211>  1059
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSG4__Homo_sapiens__NP_001127925

<400>  3281

Met Asp Trp Leu Phe Phe Arg Asn Ile Cys Leu Leu Ile Ile Leu Met 
1               5                   10                  15      


Val Val Met Glu Val Asn Ser Glu Phe Ile Val Glu Val Lys Glu Phe 
            20                  25                  30          


Asp Ile Glu Asn Gly Thr Thr Lys Trp Gln Thr Val Arg Arg Gln Lys 
        35                  40                  45              


Arg Glu Trp Ile Lys Phe Ala Ala Ala Cys Arg Glu Gly Glu Asp Asn 
    50                  55                  60                  


Ser Lys Arg Asn Pro Ile Ala Lys Ile Arg Ser Asp Cys Glu Ser Asn 
65                  70                  75                  80  


Gln Lys Ile Thr Tyr Arg Ile Ser Gly Val Gly Ile Asp Arg Pro Pro 
                85                  90                  95      


Tyr Gly Val Phe Thr Ile Asn Pro Arg Thr Gly Glu Ile Asn Ile Thr 
            100                 105                 110         


Ser Val Val Asp Arg Glu Ile Thr Pro Leu Phe Leu Ile Tyr Cys Arg 
        115                 120                 125             


Ala Leu Asn Ser Arg Gly Glu Asp Leu Glu Arg Pro Leu Glu Leu Arg 
    130                 135                 140                 


Val Lys Val Met Asp Ile Asn Asp Asn Ala Pro Val Phe Ser Gln Ser 
145                 150                 155                 160 


Val Tyr Thr Ala Ser Ile Glu Glu Asn Ser Asp Ala Asn Thr Leu Val 
                165                 170                 175     


Val Lys Leu Cys Ala Thr Asp Ala Asp Glu Glu Asn His Leu Asn Ser 
            180                 185                 190         


Lys Ile Ala Tyr Lys Ile Val Ser Gln Glu Pro Ser Gly Ala Pro Met 
        195                 200                 205             


Phe Ile Leu Asn Arg Tyr Thr Gly Glu Val Cys Thr Met Ser Ser Phe 
    210                 215                 220                 


Leu Asp Arg Glu Gln His Ser Met Tyr Asn Leu Val Val Arg Gly Ser 
225                 230                 235                 240 


Asp Arg Asp Gly Ala Ala Asp Gly Leu Ser Ser Glu Cys Asp Cys Arg 
                245                 250                 255     


Ile Lys Val Leu Asp Val Asn Asp Asn Phe Pro Thr Leu Glu Lys Thr 
            260                 265                 270         


Ser Tyr Ser Ala Ser Ile Glu Glu Asn Cys Leu Ser Ser Glu Leu Ile 
        275                 280                 285             


Arg Leu Gln Ala Ile Asp Leu Asp Glu Glu Gly Thr Asp Asn Trp Leu 
    290                 295                 300                 


Ala Gln Tyr Leu Ile Leu Ser Gly Asn Asp Gly Asn Trp Phe Asp Ile 
305                 310                 315                 320 


Gln Thr Asp Pro Gln Thr Asn Glu Gly Ile Leu Lys Val Val Lys Met 
                325                 330                 335     


Leu Asp Tyr Glu Gln Ala Pro Asn Ile Gln Leu Ser Ile Gly Val Lys 
            340                 345                 350         


Asn Gln Ala Asp Phe His Tyr Ser Val Ala Ser Gln Phe Gln Met His 
        355                 360                 365             


Pro Thr Pro Val Arg Ile Gln Val Val Asp Val Arg Glu Gly Pro Ala 
    370                 375                 380                 


Phe His Pro Ser Thr Met Ala Phe Ser Val Arg Glu Gly Ile Lys Gly 
385                 390                 395                 400 


Ser Ser Leu Leu Asn Tyr Val Leu Gly Thr Tyr Thr Ala Ile Asp Leu 
                405                 410                 415     


Asp Thr Gly Asn Pro Ala Thr Asp Val Arg Tyr Ile Ile Gly His Asp 
            420                 425                 430         


Ala Gly Ser Trp Leu Lys Ile Asp Ser Arg Thr Gly Glu Ile Gln Phe 
        435                 440                 445             


Ser Arg Glu Phe Asp Lys Lys Ser Lys Tyr Ile Ile Asn Gly Ile Tyr 
    450                 455                 460                 


Thr Ala Glu Ile Leu Ala Ile Asp Asp Gly Ser Gly Lys Thr Ala Thr 
465                 470                 475                 480 


Gly Thr Ile Cys Ile Glu Val Pro Asp Ile Asn Asp Tyr Cys Pro Asn 
                485                 490                 495     


Ile Phe Pro Glu Arg Arg Thr Ile Cys Ile Asp Ser Pro Ser Val Leu 
            500                 505                 510         


Ile Ser Val Asn Glu His Ser Tyr Gly Ser Pro Phe Thr Phe Cys Val 
        515                 520                 525             


Val Asp Glu Pro Pro Gly Ile Ala Asp Met Trp Asp Val Arg Ser Thr 
    530                 535                 540                 


Asn Ala Thr Ser Ala Ile Leu Thr Ala Lys Gln Val Leu Ser Pro Gly 
545                 550                 555                 560 


Phe Tyr Glu Ile Pro Ile Leu Val Lys Asp Ser Tyr Asn Arg Ala Cys 
                565                 570                 575     


Glu Leu Ala Gln Met Val Gln Leu Tyr Ala Cys Asp Cys Asp Asp Asn 
            580                 585                 590         


His Met Cys Leu Asp Ser Gly Ala Ala Gly Ile Tyr Thr Glu Asp Ile 
        595                 600                 605             


Thr Gly Asp Thr Tyr Gly Pro Val Thr Glu Asp Gln Ala Gly Val Ser 
    610                 615                 620                 


Asn Val Gly Leu Gly Pro Ala Gly Ile Gly Met Met Val Leu Gly Ile 
625                 630                 635                 640 


Leu Leu Leu Ile Leu Ala Pro Leu Leu Leu Leu Leu Cys Cys Cys Lys 
                645                 650                 655     


Gln Arg Gln Pro Glu Gly Leu Gly Thr Arg Phe Ala Pro Val Pro Glu 
            660                 665                 670         


Gly Gly Glu Gly Val Met Gln Ser Trp Arg Ile Glu Gly Ala His Pro 
        675                 680                 685             


Glu Asp Arg Leu Phe Ser Ala Tyr Ala Leu Pro Gly Gly Gly Gly Thr 
    690                 695                 700                 


Ala Asp Gly Gly Gly Ser Val Leu Gly Arg Cys Ala Leu Gln Ala Thr 
705                 710                 715                 720 


Pro Ala Leu Leu Asn Gln His Pro Pro Phe Ser Glu Ile Tyr Thr Asn 
                725                 730                 735     


Thr Tyr Ala Ala Gly Gly Thr Val Glu Gly Gly Val Ser Gly Val Glu 
            740                 745                 750         


Leu Asn Thr Gly Met Gly Thr Ala Val Gly Leu Met Ala Ala Gly Ala 
        755                 760                 765             


Ala Gly Ala Ser Gly Ala Ala Arg Lys Arg Ser Ser Thr Met Gly Thr 
    770                 775                 780                 


Leu Arg Asp Tyr Ala Asp Ala Asp Ile Asn Met Ala Phe Leu Asp Ser 
785                 790                 795                 800 


Tyr Phe Ser Glu Lys Ala Tyr Ala Tyr Ala Asp Glu Asp Glu Gly Arg 
                805                 810                 815     


Pro Ala Asn Asp Cys Leu Leu Ile Tyr Asp His Glu Gly Val Gly Ser 
            820                 825                 830         


Pro Val Gly Ser Ile Gly Cys Cys Ser Trp Ile Val Asp Asp Leu Asp 
        835                 840                 845             


Glu Ser Cys Met Glu Thr Leu Asp Pro Lys Phe Arg Thr Leu Ala Glu 
    850                 855                 860                 


Ile Cys Leu Asn Thr Glu Ile Glu Pro Phe Pro Ser His Gln Ala Cys 
865                 870                 875                 880 


Ile Pro Ile Ser Thr Asp Leu Pro Leu Leu Gly Pro Asn Tyr Phe Val 
                885                 890                 895     


Asn Glu Ser Ser Gly Leu Thr Pro Ser Glu Val Glu Phe Gln Glu Glu 
            900                 905                 910         


Met Ala Ala Ser Glu Pro Val Val His Gly Asp Ile Ile Val Thr Glu 
        915                 920                 925             


Thr Tyr Gly Asn Ala Asp Pro Cys Val Gln Pro Thr Thr Ile Ile Phe 
    930                 935                 940                 


Asp Pro Gln Leu Ala Pro Asn Val Val Val Thr Glu Ala Val Met Ala 
945                 950                 955                 960 


Pro Val Tyr Asp Ile Gln Gly Asn Ile Cys Val Pro Ala Glu Leu Ala 
                965                 970                 975     


Asp Tyr Asn Asn Val Ile Tyr Ala Glu Arg Val Leu Ala Ser Pro Gly 
            980                 985                 990         


Val Pro Asp Met Ser Asn Ser Ser  Thr Thr Glu Gly Cys  Met Gly Pro 
        995                 1000                 1005             


Val Met  Ser Gly Asn Ile Leu  Val Gly Pro Glu Ile  Gln Val Met 
    1010                 1015                 1020             


Gln Met  Met Ser Pro Asp Leu  Pro Ile Gly Gln Thr  Val Gly Ser 
    1025                 1030                 1035             


Thr Ser  Pro Met Thr Ser Arg  His Arg Val Thr Arg  Tyr Ser Asn 
    1040                 1045                 1050             


Ile His  Tyr Thr Gln Gln 
    1055                 


<210>  3282
<211>  2272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSP__Homo_sapiens__NP_001008844

<400>  3282

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Ala  Ser Asn Arg Ile Gln  Glu Ser Lys 
    1190                 1195                 1200             


Asn Gln  Cys Thr Gln Val Val  Gln Glu Arg Glu Ser  Leu Leu Val 
    1205                 1210                 1215             


Lys Ile  Lys Val Leu Glu Gln  Asp Lys Ala Arg Leu  Gln Arg Leu 
    1220                 1225                 1230             


Glu Asp  Glu Leu Asn Arg Ala  Lys Ser Thr Leu Glu  Ala Glu Thr 
    1235                 1240                 1245             


Arg Val  Lys Gln Arg Leu Glu  Cys Glu Lys Gln Gln  Ile Gln Asn 
    1250                 1255                 1260             


Asp Leu  Asn Gln Trp Lys Thr  Gln Tyr Ser Arg Lys  Glu Glu Ala 
    1265                 1270                 1275             


Ile Arg  Lys Ile Glu Ser Glu  Arg Glu Lys Ser Glu  Arg Glu Lys 
    1280                 1285                 1290             


Asn Ser  Leu Arg Ser Glu Ile  Glu Arg Leu Gln Ala  Glu Ile Lys 
    1295                 1300                 1305             


Arg Ile  Glu Glu Arg Cys Arg  Arg Lys Leu Glu Asp  Ser Thr Arg 
    1310                 1315                 1320             


Glu Thr  Gln Ser Gln Leu Glu  Thr Glu Arg Ser Arg  Tyr Gln Arg 
    1325                 1330                 1335             


Glu Ile  Asp Lys Leu Arg Gln  Arg Pro Tyr Gly Ser  His Arg Glu 
    1340                 1345                 1350             


Thr Gln  Thr Glu Cys Glu Trp  Thr Val Asp Thr Ser  Lys Leu Val 
    1355                 1360                 1365             


Phe Asp  Gly Leu Arg Lys Lys  Val Thr Ala Met Gln  Leu Tyr Glu 
    1370                 1375                 1380             


Cys Gln  Leu Ile Asp Lys Thr  Thr Leu Asp Lys Leu  Leu Lys Gly 
    1385                 1390                 1395             


Lys Lys  Ser Val Glu Glu Val  Ala Ser Glu Ile Gln  Pro Phe Leu 
    1400                 1405                 1410             


Arg Gly  Ala Gly Ser Ile Ala  Gly Ala Ser Ala Ser  Pro Lys Glu 
    1415                 1420                 1425             


Lys Tyr  Ser Leu Val Glu Ala  Lys Arg Lys Lys Leu  Ile Ser Pro 
    1430                 1435                 1440             


Glu Ser  Thr Val Met Leu Leu  Glu Ala Gln Ala Ala  Thr Gly Gly 
    1445                 1450                 1455             


Ile Ile  Asp Pro His Arg Asn  Glu Lys Leu Thr Val  Asp Ser Ala 
    1460                 1465                 1470             


Ile Ala  Arg Asp Leu Ile Asp  Phe Asp Asp Arg Gln  Gln Ile Tyr 
    1475                 1480                 1485             


Ala Ala  Glu Lys Ala Ile Thr  Gly Phe Asp Asp Pro  Phe Ser Gly 
    1490                 1495                 1500             


Lys Thr  Val Ser Val Ser Glu  Ala Ile Lys Lys Asn  Leu Ile Asp 
    1505                 1510                 1515             


Arg Glu  Thr Gly Met Arg Leu  Leu Glu Ala Gln Ile  Ala Ser Gly 
    1520                 1525                 1530             


Gly Val  Val Asp Pro Val Asn  Ser Val Phe Leu Pro  Lys Asp Val 
    1535                 1540                 1545             


Ala Leu  Ala Arg Gly Leu Ile  Asp Arg Asp Leu Tyr  Arg Ser Leu 
    1550                 1555                 1560             


Asn Asp  Pro Arg Asp Ser Gln  Lys Asn Phe Val Asp  Pro Val Thr 
    1565                 1570                 1575             


Lys Lys  Lys Val Ser Tyr Val  Gln Leu Lys Glu Arg  Cys Arg Ile 
    1580                 1585                 1590             


Glu Pro  His Thr Gly Leu Leu  Leu Leu Ser Val Gln  Lys Arg Ser 
    1595                 1600                 1605             


Met Ser  Phe Gln Gly Ile Arg  Gln Pro Val Thr Val  Thr Glu Leu 
    1610                 1615                 1620             


Val Asp  Ser Gly Ile Leu Arg  Pro Ser Thr Val Asn  Glu Leu Glu 
    1625                 1630                 1635             


Ser Gly  Gln Ile Ser Tyr Asp  Glu Val Gly Glu Arg  Ile Lys Asp 
    1640                 1645                 1650             


Phe Leu  Gln Gly Ser Ser Cys  Ile Ala Gly Ile Tyr  Asn Glu Thr 
    1655                 1660                 1665             


Thr Lys  Gln Lys Leu Gly Ile  Tyr Glu Ala Met Lys  Ile Gly Leu 
    1670                 1675                 1680             


Val Arg  Pro Gly Thr Ala Leu  Glu Leu Leu Glu Ala  Gln Ala Ala 
    1685                 1690                 1695             


Thr Gly  Phe Ile Val Asp Pro  Val Ser Asn Leu Arg  Leu Pro Val 
    1700                 1705                 1710             


Glu Glu  Ala Tyr Lys Arg Gly  Leu Val Gly Ile Glu  Phe Lys Glu 
    1715                 1720                 1725             


Lys Leu  Leu Ser Ala Glu Arg  Ala Val Thr Gly Tyr  Asn Asp Pro 
    1730                 1735                 1740             


Glu Thr  Gly Asn Ile Ile Ser  Leu Phe Gln Ala Met  Asn Lys Glu 
    1745                 1750                 1755             


Leu Ile  Glu Lys Gly His Gly  Ile Arg Leu Leu Glu  Ala Gln Ile 
    1760                 1765                 1770             


Ala Thr  Gly Gly Ile Ile Asp  Pro Lys Glu Ser His  Arg Leu Pro 
    1775                 1780                 1785             


Val Asp  Ile Ala Tyr Lys Arg  Gly Tyr Phe Asn Glu  Glu Leu Ser 
    1790                 1795                 1800             


Glu Ile  Leu Ser Asp Pro Ser  Asp Asp Thr Lys Gly  Phe Phe Asp 
    1805                 1810                 1815             


Pro Asn  Thr Glu Glu Asn Leu  Thr Tyr Leu Gln Leu  Lys Glu Arg 
    1820                 1825                 1830             


Cys Ile  Lys Asp Glu Glu Thr  Gly Leu Cys Leu Leu  Pro Leu Lys 
    1835                 1840                 1845             


Glu Lys  Lys Lys Gln Val Gln  Thr Ser Gln Lys Asn  Thr Leu Arg 
    1850                 1855                 1860             


Lys Arg  Arg Val Val Ile Val  Asp Pro Glu Thr Asn  Lys Glu Met 
    1865                 1870                 1875             


Ser Val  Gln Glu Ala Tyr Lys  Lys Gly Leu Ile Asp  Tyr Glu Thr 
    1880                 1885                 1890             


Phe Lys  Glu Leu Cys Glu Gln  Glu Cys Glu Trp Glu  Glu Ile Thr 
    1895                 1900                 1905             


Ile Thr  Gly Ser Asp Gly Ser  Thr Arg Val Val Leu  Val Asp Arg 
    1910                 1915                 1920             


Lys Thr  Gly Ser Gln Tyr Asp  Ile Gln Asp Ala Ile  Asp Lys Gly 
    1925                 1930                 1935             


Leu Val  Asp Arg Lys Phe Phe  Asp Gln Tyr Arg Ser  Gly Ser Leu 
    1940                 1945                 1950             


Ser Leu  Thr Gln Phe Ala Asp  Met Ile Ser Leu Lys  Asn Gly Val 
    1955                 1960                 1965             


Gly Thr  Ser Ser Ser Met Gly  Ser Gly Val Ser Asp  Asp Val Phe 
    1970                 1975                 1980             


Ser Ser  Ser Arg His Glu Ser  Val Ser Lys Ile Ser  Thr Ile Ser 
    1985                 1990                 1995             


Ser Val  Arg Asn Leu Thr Ile  Arg Ser Ser Ser Phe  Ser Asp Thr 
    2000                 2005                 2010             


Leu Glu  Glu Ser Ser Pro Ile  Ala Ala Ile Phe Asp  Thr Glu Asn 
    2015                 2020                 2025             


Leu Glu  Lys Ile Ser Ile Thr  Glu Gly Ile Glu Arg  Gly Ile Val 
    2030                 2035                 2040             


Asp Ser  Ile Thr Gly Gln Arg  Leu Leu Glu Ala Gln  Ala Cys Thr 
    2045                 2050                 2055             


Gly Gly  Ile Ile His Pro Thr  Thr Gly Gln Lys Leu  Ser Leu Gln 
    2060                 2065                 2070             


Asp Ala  Val Ser Gln Gly Val  Ile Asp Gln Asp Met  Ala Thr Arg 
    2075                 2080                 2085             


Leu Lys  Pro Ala Gln Lys Ala  Phe Ile Gly Phe Glu  Gly Val Lys 
    2090                 2095                 2100             


Gly Lys  Lys Lys Met Ser Ala  Ala Glu Ala Val Lys  Glu Lys Trp 
    2105                 2110                 2115             


Leu Pro  Tyr Glu Ala Gly Gln  Arg Phe Leu Glu Phe  Gln Tyr Leu 
    2120                 2125                 2130             


Thr Gly  Gly Leu Val Asp Pro  Glu Val His Gly Arg  Ile Ser Thr 
    2135                 2140                 2145             


Glu Glu  Ala Ile Arg Lys Gly  Phe Ile Asp Gly Arg  Ala Ala Gln 
    2150                 2155                 2160             


Arg Leu  Gln Asp Thr Ser Ser  Tyr Ala Lys Ile Leu  Thr Cys Pro 
    2165                 2170                 2175             


Lys Thr  Lys Leu Lys Ile Ser  Tyr Lys Asp Ala Ile  Asn Arg Ser 
    2180                 2185                 2190             


Met Val  Glu Asp Ile Thr Gly  Leu Arg Leu Leu Glu  Ala Ala Ser 
    2195                 2200                 2205             


Val Ser  Ser Lys Gly Leu Pro  Ser Pro Tyr Asn Met  Ser Ser Ala 
    2210                 2215                 2220             


Pro Gly  Ser Arg Ser Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser 
    2225                 2230                 2235             


Arg Ser  Gly Ser Arg Ser Gly  Ser Arg Arg Gly Ser  Phe Asp Ala 
    2240                 2245                 2250             


Thr Gly  Asn Ser Ser Tyr Ser  Tyr Ser Tyr Ser Phe  Ser Ser Ser 
    2255                 2260                 2265             


Ser Ile  Gly His 
    2270         


<210>  3283
<211>  1301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSPP__Homo_sapiens__NP_055023

<400>  3283

Met Lys Ile Ile Thr Tyr Phe Cys Ile Trp Ala Val Ala Trp Ala Ile 
1               5                   10                  15      


Pro Val Pro Gln Ser Lys Pro Leu Glu Arg His Val Glu Lys Ser Met 
            20                  25                  30          


Asn Leu His Leu Leu Ala Arg Ser Asn Val Ser Val Gln Asp Glu Leu 
        35                  40                  45              


Asn Ala Ser Gly Thr Ile Lys Glu Ser Gly Val Leu Val His Glu Gly 
    50                  55                  60                  


Asp Arg Gly Arg Gln Glu Asn Thr Gln Asp Gly His Lys Gly Glu Gly 
65                  70                  75                  80  


Asn Gly Ser Lys Trp Ala Glu Val Gly Gly Lys Ser Phe Ser Thr Tyr 
                85                  90                  95      


Ser Thr Leu Ala Asn Glu Glu Gly Asn Ile Glu Gly Trp Asn Gly Asp 
            100                 105                 110         


Thr Gly Lys Ala Glu Thr Tyr Gly His Asp Gly Ile His Gly Lys Glu 
        115                 120                 125             


Glu Asn Ile Thr Ala Asn Gly Ile Gln Gly Gln Val Ser Ile Ile Asp 
    130                 135                 140                 


Asn Ala Gly Ala Thr Asn Arg Ser Asn Thr Asn Gly Asn Thr Asp Lys 
145                 150                 155                 160 


Asn Thr Gln Asn Gly Asp Val Gly Asp Ala Gly His Asn Glu Asp Val 
                165                 170                 175     


Ala Val Val Gln Glu Asp Gly Pro Gln Val Ala Gly Ser Asn Asn Ser 
            180                 185                 190         


Thr Asp Asn Glu Asp Glu Ile Ile Glu Asn Ser Cys Arg Asn Glu Gly 
        195                 200                 205             


Asn Thr Ser Glu Ile Thr Pro Gln Ile Asn Ser Lys Arg Asn Gly Thr 
    210                 215                 220                 


Lys Glu Ala Glu Val Thr Pro Gly Thr Gly Glu Asp Ala Gly Leu Asp 
225                 230                 235                 240 


Asn Ser Asp Gly Ser Pro Ser Gly Asn Gly Ala Asp Glu Asp Glu Asp 
                245                 250                 255     


Glu Gly Ser Gly Asp Asp Glu Asp Glu Glu Ala Gly Asn Gly Lys Asp 
            260                 265                 270         


Ser Ser Asn Asn Ser Lys Gly Gln Glu Gly Gln Asp His Gly Lys Glu 
        275                 280                 285             


Asp Asp His Asp Ser Ser Ile Gly Gln Asn Ser Asp Ser Lys Glu Tyr 
    290                 295                 300                 


Tyr Asp Pro Glu Gly Lys Glu Asp Pro His Asn Glu Val Asp Gly Asp 
305                 310                 315                 320 


Lys Thr Ser Lys Ser Glu Glu Asn Ser Ala Gly Ile Pro Glu Asp Asn 
                325                 330                 335     


Gly Ser Gln Arg Ile Glu Asp Thr Gln Lys Leu Asn His Arg Glu Ser 
            340                 345                 350         


Lys Arg Val Glu Asn Arg Ile Thr Lys Glu Ser Glu Thr His Ala Val 
        355                 360                 365             


Gly Lys Ser Gln Asp Lys Gly Ile Glu Ile Lys Gly Pro Ser Ser Gly 
    370                 375                 380                 


Asn Arg Asn Ile Thr Lys Glu Val Gly Lys Gly Asn Glu Gly Lys Glu 
385                 390                 395                 400 


Asp Lys Gly Gln His Gly Met Ile Leu Gly Lys Gly Asn Val Lys Thr 
                405                 410                 415     


Gln Gly Glu Val Val Asn Ile Glu Gly Pro Gly Gln Lys Ser Glu Pro 
            420                 425                 430         


Gly Asn Lys Val Gly His Ser Asn Thr Gly Ser Asp Ser Asn Ser Asp 
        435                 440                 445             


Gly Tyr Asp Ser Tyr Asp Phe Asp Asp Lys Ser Met Gln Gly Asp Asp 
    450                 455                 460                 


Pro Asn Ser Ser Asp Glu Ser Asn Gly Asn Asp Asp Ala Asn Ser Glu 
465                 470                 475                 480 


Ser Asp Asn Asn Ser Ser Ser Arg Gly Asp Ala Ser Tyr Asn Ser Asp 
                485                 490                 495     


Glu Ser Lys Asp Asn Gly Asn Gly Ser Asp Ser Lys Gly Ala Glu Asp 
            500                 505                 510         


Asp Asp Ser Asp Ser Thr Ser Asp Thr Asn Asn Ser Asp Ser Asn Gly 
        515                 520                 525             


Asn Gly Asn Asn Gly Asn Asp Asp Asn Asp Lys Ser Asp Ser Gly Lys 
    530                 535                 540                 


Gly Lys Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser 
545                 550                 555                 560 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Asn Ser 
                565                 570                 575     


Ser Ser Asp Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp 
            580                 585                 590         


Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser 
        595                 600                 605             


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Lys Ser 
    610                 615                 620                 


Asp Ser Ser Lys Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Lys Ser 
625                 630                 635                 640 


Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser Ser Asp Asn Ser Asp Ser 
                645                 650                 655     


Ser Asp Ser Ser Asn Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser 
            660                 665                 670         


Asp Ser Ser Asp Ser Ser Ser Ser Ser Asp Ser Ser Asn Ser Ser Asp 
        675                 680                 685             


Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Glu Ser Ser Asp Ser 
    690                 695                 700                 


Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn 
705                 710                 715                 720 


Ser Asn Ser Ser Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp 
                725                 730                 735     


Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser 
            740                 745                 750         


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
        755                 760                 765             


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp 
    770                 775                 780                 


Ser Asn Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser 
785                 790                 795                 800 


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
                805                 810                 815     


Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
            820                 825                 830         


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
        835                 840                 845             


Asp Gly Ser Asp Ser Asp Ser Ser Asn Arg Ser Asp Ser Ser Asn Ser 
    850                 855                 860                 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
865                 870                 875                 880 


Asp Ser Ser Asp Ser Asn Glu Ser Ser Asn Ser Ser Asp Ser Ser Asp 
                885                 890                 895     


Ser Ser Asn Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser 
            900                 905                 910         


Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Glu Ser Ser Asn 
        915                 920                 925             


Ser Ser Asp Asn Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
    930                 935                 940                 


Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser 
945                 950                 955                 960 


Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser 
                965                 970                 975     


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
            980                 985                 990         


Asp Ser Ser Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
        995                 1000                 1005             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asn 
    1010                 1015                 1020             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1025                 1030                 1035             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1040                 1045                 1050             


Ser Ser  Asn Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1055                 1060                 1065             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Glu 
    1070                 1075                 1080             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1085                 1090                 1095             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1100                 1105                 1110             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1115                 1120                 1125             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asn  Ser Ser Asp 
    1130                 1135                 1140             


Ser Ser  Asp Ser Ser Glu Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1145                 1150                 1155             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1160                 1165                 1170             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1175                 1180                 1185             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1190                 1195                 1200             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1205                 1210                 1215             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Asn Glu 
    1220                 1225                 1230             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asn 
    1235                 1240                 1245             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Thr Ser 
    1250                 1255                 1260             


Asp Ser  Asn Asp Glu Ser Asp  Ser Gln Ser Lys Ser  Gly Asn Gly 
    1265                 1270                 1275             


Asn Asn  Asn Gly Ser Asp Ser  Asp Ser Asp Ser Glu  Gly Ser Asp 
    1280                 1285                 1290             


Ser Asn  His Ser Thr Ser Asp  Asp 
    1295                 1300     


<210>  3284
<211>  2649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DST__Homo_sapiens__NP_001714

<400>  3284

Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser 
1               5                   10                  15      


Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu 
            20                  25                  30          


Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly 
        35                  40                  45              


Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala 
    50                  55                  60                  


Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu 
65                  70                  75                  80  


Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val 
                85                  90                  95      


Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu 
            100                 105                 110         


Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly 
        115                 120                 125             


Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg 
    130                 135                 140                 


Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys 
145                 150                 155                 160 


Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile 
                165                 170                 175     


Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu 
            180                 185                 190         


Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser 
        195                 200                 205             


Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser 
    210                 215                 220                 


Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn 
225                 230                 235                 240 


Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met 
                245                 250                 255     


Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp 
        275                 280                 285             


Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp 
    290                 295                 300                 


Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg 
305                 310                 315                 320 


Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu 
                325                 330                 335     


Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His 
            340                 345                 350         


Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln 
        355                 360                 365             


Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn 
    370                 375                 380                 


Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp 
385                 390                 395                 400 


Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala 
                405                 410                 415     


Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val 
            420                 425                 430         


Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu 
        435                 440                 445             


Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile 
    450                 455                 460                 


Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala 
465                 470                 475                 480 


Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg 
                485                 490                 495     


Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser 
            500                 505                 510         


Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys 
        515                 520                 525             


Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys 
    530                 535                 540                 


Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu 
545                 550                 555                 560 


Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu 
                565                 570                 575     


Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His 
            580                 585                 590         


Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val 
        595                 600                 605             


Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp 
    610                 615                 620                 


Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp 
625                 630                 635                 640 


His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu 
                645                 650                 655     


Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys 
            660                 665                 670         


Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser 
        675                 680                 685             


Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser 
    690                 695                 700                 


Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln 
705                 710                 715                 720 


Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu 
                725                 730                 735     


Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg 
            740                 745                 750         


Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu 
        755                 760                 765             


Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu 
    770                 775                 780                 


Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile 
785                 790                 795                 800 


Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser 
                805                 810                 815     


Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn 
            820                 825                 830         


Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val 
        835                 840                 845             


Asn Leu Val Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu 
    850                 855                 860                 


Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn 
865                 870                 875                 880 


Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val 
                885                 890                 895     


Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys 
            900                 905                 910         


Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp 
        915                 920                 925             


Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg 
    930                 935                 940                 


Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu 
945                 950                 955                 960 


Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu 
                965                 970                 975     


Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu 
            980                 985                 990         


Asn Gln Pro Glu Asn Ser Lys Thr  Leu Ala Thr Gln Leu  Asn Gln Gln 
        995                 1000                 1005             


Lys Met  Leu Val Ser Glu Ile  Glu Met Lys Gln Ser  Lys Met Asp 
    1010                 1015                 1020             


Glu Cys  Gln Lys Tyr Ala Glu  Gln Tyr Ser Ala Thr  Val Lys Asp 
    1025                 1030                 1035             


Tyr Glu  Leu Gln Thr Met Thr  Tyr Arg Ala Met Val  Asp Ser Gln 
    1040                 1045                 1050             


Gln Lys  Ser Pro Val Lys Arg  Arg Arg Met Gln Ser  Ser Ala Asp 
    1055                 1060                 1065             


Leu Ile  Ile Gln Glu Phe Met  Asp Leu Arg Thr Arg  Tyr Thr Ala 
    1070                 1075                 1080             


Leu Val  Thr Leu Met Thr Gln  Tyr Ile Lys Phe Ala  Gly Asp Ser 
    1085                 1090                 1095             


Leu Lys  Arg Leu Glu Glu Glu  Glu Ile Lys Arg Cys  Lys Glu Thr 
    1100                 1105                 1110             


Ser Glu  His Gly Ala Tyr Ser  Asp Leu Leu Gln Arg  Gln Lys Ala 
    1115                 1120                 1125             


Thr Val  Leu Glu Asn Ser Lys  Leu Thr Gly Lys Ile  Ser Glu Leu 
    1130                 1135                 1140             


Glu Arg  Met Val Ala Glu Leu  Lys Lys Gln Lys Ser  Arg Val Glu 
    1145                 1150                 1155             


Glu Glu  Leu Pro Lys Val Arg  Glu Ala Ala Glu Asn  Glu Leu Arg 
    1160                 1165                 1170             


Lys Gln  Gln Arg Asn Val Glu  Asp Ile Ser Leu Gln  Lys Ile Arg 
    1175                 1180                 1185             


Ala Glu  Ser Glu Ala Lys Gln  Tyr Arg Arg Glu Leu  Glu Thr Ile 
    1190                 1195                 1200             


Val Arg  Glu Lys Glu Ala Ala  Glu Arg Glu Leu Glu  Arg Val Arg 
    1205                 1210                 1215             


Gln Leu  Thr Ile Glu Ala Glu  Ala Lys Arg Ala Ala  Val Glu Glu 
    1220                 1225                 1230             


Asn Leu  Leu Asn Phe Arg Asn  Gln Leu Glu Glu Asn  Thr Phe Thr 
    1235                 1240                 1245             


Arg Arg  Thr Leu Glu Asp His  Leu Lys Arg Lys Asp  Leu Ser Leu 
    1250                 1255                 1260             


Asn Asp  Leu Glu Gln Gln Lys  Asn Lys Leu Met Glu  Glu Leu Arg 
    1265                 1270                 1275             


Arg Lys  Arg Asp Asn Glu Glu  Glu Leu Leu Lys Leu  Ile Lys Gln 
    1280                 1285                 1290             


Met Glu  Lys Asp Leu Ala Phe  Gln Lys Gln Val Ala  Glu Lys Gln 
    1295                 1300                 1305             


Leu Lys  Glu Lys Gln Lys Ile  Glu Leu Glu Ala Arg  Arg Lys Ile 
    1310                 1315                 1320             


Thr Glu  Ile Gln Tyr Thr Cys  Arg Glu Asn Ala Leu  Pro Val Cys 
    1325                 1330                 1335             


Pro Ile  Thr Gln Ala Thr Ser  Cys Arg Ala Val Thr  Gly Leu Gln 
    1340                 1345                 1350             


Gln Glu  His Asp Lys Gln Lys  Ala Glu Glu Leu Lys  Gln Gln Val 
    1355                 1360                 1365             


Asp Glu  Leu Thr Ala Ala Asn  Arg Lys Ala Glu Gln  Asp Met Arg 
    1370                 1375                 1380             


Glu Leu  Thr Tyr Glu Leu Asn  Ala Leu Gln Leu Glu  Lys Thr Ser 
    1385                 1390                 1395             


Ser Glu  Glu Lys Ala Arg Leu  Leu Lys Asp Lys Leu  Asp Glu Thr 
    1400                 1405                 1410             


Asn Asn  Thr Leu Arg Cys Leu  Lys Leu Glu Leu Glu  Arg Lys Asp 
    1415                 1420                 1425             


Gln Ala  Glu Lys Gly Tyr Ser  Gln Gln Leu Arg Glu  Leu Gly Arg 
    1430                 1435                 1440             


Gln Leu  Asn Gln Thr Thr Gly  Lys Ala Glu Glu Ala  Met Gln Glu 
    1445                 1450                 1455             


Ala Ser  Asp Leu Lys Lys Ile  Lys Arg Asn Tyr Gln  Leu Glu Leu 
    1460                 1465                 1470             


Glu Ser  Leu Asn His Glu Lys  Gly Lys Leu Gln Arg  Glu Val Asp 
    1475                 1480                 1485             


Arg Ile  Thr Arg Ala His Ala  Val Ala Glu Lys Asn  Ile Gln His 
    1490                 1495                 1500             


Leu Asn  Ser Gln Ile His Ser  Phe Arg Asp Glu Lys  Glu Leu Glu 
    1505                 1510                 1515             


Arg Leu  Gln Ile Cys Gln Arg  Lys Ser Asp His Leu  Lys Glu Gln 
    1520                 1525                 1530             


Phe Glu  Lys Ser His Glu Gln  Leu Leu Gln Asn Ile  Lys Ala Glu 
    1535                 1540                 1545             


Lys Glu  Asn Asn Asp Lys Ile  Gln Arg Leu Asn Glu  Glu Leu Glu 
    1550                 1555                 1560             


Lys Ser  Asn Glu Cys Ala Glu  Met Leu Lys Gln Lys  Val Glu Glu 
    1565                 1570                 1575             


Leu Thr  Arg Gln Asn Asn Glu  Thr Lys Leu Met Met  Gln Arg Ile 
    1580                 1585                 1590             


Gln Ala  Glu Ser Glu Asn Ile  Val Leu Glu Lys Gln  Thr Ile Gln 
    1595                 1600                 1605             


Gln Arg  Cys Glu Ala Leu Lys  Ile Gln Ala Asp Gly  Phe Lys Asp 
    1610                 1615                 1620             


Gln Leu  Arg Ser Thr Asn Glu  His Leu His Lys Gln  Thr Lys Thr 
    1625                 1630                 1635             


Glu Gln  Asp Phe Gln Arg Lys  Ile Lys Cys Leu Glu  Glu Asp Leu 
    1640                 1645                 1650             


Ala Lys  Ser Gln Asn Leu Val  Ser Glu Phe Lys Gln  Lys Cys Asp 
    1655                 1660                 1665             


Gln Gln  Asn Ile Ile Ile Gln  Asn Thr Lys Lys Glu  Val Arg Asn 
    1670                 1675                 1680             


Leu Asn  Ala Glu Leu Asn Ala  Ser Lys Glu Glu Lys  Arg Arg Gly 
    1685                 1690                 1695             


Glu Gln  Lys Val Gln Leu Gln  Gln Ala Gln Val Gln  Glu Leu Asn 
    1700                 1705                 1710             


Asn Arg  Leu Lys Lys Val Gln  Asp Glu Leu His Leu  Lys Thr Ile 
    1715                 1720                 1725             


Glu Glu  Gln Met Thr His Arg  Lys Met Val Leu Phe  Gln Glu Glu 
    1730                 1735                 1740             


Ser Gly  Lys Phe Lys Gln Ser  Ala Glu Glu Phe Arg  Lys Lys Met 
    1745                 1750                 1755             


Glu Lys  Leu Met Glu Ser Lys  Val Ile Thr Glu Asn  Asp Ile Ser 
    1760                 1765                 1770             


Gly Ile  Arg Leu Asp Phe Val  Ser Leu Gln Gln Glu  Asn Ser Arg 
    1775                 1780                 1785             


Ala Gln  Glu Asn Ala Lys Leu  Cys Glu Thr Asn Ile  Lys Glu Leu 
    1790                 1795                 1800             


Glu Arg  Gln Leu Gln Gln Tyr  Arg Glu Gln Met Gln  Gln Gly Gln 
    1805                 1810                 1815             


His Met  Glu Ala Asn His Tyr  Gln Lys Cys Gln Lys  Leu Glu Asp 
    1820                 1825                 1830             


Glu Leu  Ile Ala Gln Lys Arg  Glu Val Glu Asn Leu  Lys Gln Lys 
    1835                 1840                 1845             


Met Asp  Gln Gln Ile Lys Glu  His Glu His Gln Leu  Val Leu Leu 
    1850                 1855                 1860             


Gln Cys  Glu Ile Gln Lys Lys  Ser Thr Ala Lys Asp  Cys Thr Phe 
    1865                 1870                 1875             


Lys Pro  Asp Phe Glu Met Thr  Val Lys Glu Cys Gln  His Ser Gly 
    1880                 1885                 1890             


Glu Leu  Ser Ser Arg Asn Thr  Gly His Leu His Pro  Thr Pro Arg 
    1895                 1900                 1905             


Ser Pro  Leu Leu Arg Trp Thr  Gln Glu Pro Gln Pro  Leu Glu Glu 
    1910                 1915                 1920             


Lys Trp  Gln His Arg Val Val  Glu Gln Ile Pro Lys  Glu Val Gln 
    1925                 1930                 1935             


Phe Gln  Pro Pro Gly Ala Pro  Leu Glu Lys Glu Lys  Ser Gln Gln 
    1940                 1945                 1950             


Cys Tyr  Ser Glu Tyr Phe Ser  Gln Thr Ser Thr Glu  Leu Gln Ile 
    1955                 1960                 1965             


Thr Phe  Asp Glu Thr Asn Pro  Ile Thr Arg Leu Ser  Glu Ile Glu 
    1970                 1975                 1980             


Lys Ile  Arg Asp Gln Ala Leu  Asn Asn Ser Arg Pro  Pro Val Arg 
    1985                 1990                 1995             


Tyr Gln  Asp Asn Ala Cys Glu  Met Glu Leu Val Lys  Val Leu Thr 
    2000                 2005                 2010             


Pro Leu  Glu Ile Ala Lys Asn  Lys Gln Tyr Asp Met  His Thr Glu 
    2015                 2020                 2025             


Val Thr  Thr Leu Lys Gln Glu  Lys Asn Pro Val Pro  Ser Ala Glu 
    2030                 2035                 2040             


Glu Trp  Met Leu Glu Gly Cys  Arg Ala Ser Gly Gly  Leu Lys Lys 
    2045                 2050                 2055             


Gly Asp  Phe Leu Lys Lys Gly  Leu Glu Pro Glu Thr  Phe Gln Asn 
    2060                 2065                 2070             


Phe Asp  Gly Asp His Ala Cys  Ser Val Arg Asp Asp  Glu Phe Lys 
    2075                 2080                 2085             


Phe Gln  Gly Leu Arg His Thr  Val Thr Ala Arg Gln  Leu Val Glu 
    2090                 2095                 2100             


Ala Lys  Leu Leu Asp Met Arg  Thr Ile Glu Gln Leu  Arg Leu Gly 
    2105                 2110                 2115             


Leu Lys  Thr Val Glu Glu Val  Gln Lys Thr Leu Asn  Lys Phe Leu 
    2120                 2125                 2130             


Thr Lys  Ala Thr Ser Ile Ala  Gly Leu Tyr Leu Glu  Ser Thr Lys 
    2135                 2140                 2145             


Glu Lys  Ile Ser Phe Ala Ser  Ala Ala Glu Arg Ile  Ile Ile Asp 
    2150                 2155                 2160             


Lys Met  Val Ala Leu Ala Phe  Leu Glu Ala Gln Ala  Ala Thr Gly 
    2165                 2170                 2175             


Phe Ile  Ile Asp Pro Ile Ser  Gly Gln Thr Tyr Ser  Val Glu Asp 
    2180                 2185                 2190             


Ala Val  Leu Lys Gly Val Val  Asp Pro Glu Phe Arg  Ile Arg Leu 
    2195                 2200                 2205             


Leu Glu  Ala Glu Lys Ala Ala  Val Gly Tyr Ser Tyr  Ser Ser Lys 
    2210                 2215                 2220             


Thr Leu  Ser Val Phe Gln Ala  Met Glu Asn Arg Met  Leu Asp Arg 
    2225                 2230                 2235             


Gln Lys  Gly Lys His Ile Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2240                 2245                 2250             


Val Ile  Asp Pro Val Arg Gly  Ile Arg Val Pro Pro  Glu Ile Ala 
    2255                 2260                 2265             


Leu Gln  Gln Gly Leu Leu Asn  Asn Ala Ile Leu Gln  Phe Leu His 
    2270                 2275                 2280             


Glu Pro  Ser Ser Asn Thr Arg  Val Phe Pro Asn Pro  Asn Asn Lys 
    2285                 2290                 2295             


Gln Ala  Leu Tyr Tyr Ser Glu  Leu Leu Arg Met Cys  Val Phe Asp 
    2300                 2305                 2310             


Val Glu  Ser Gln Cys Phe Leu  Phe Pro Phe Gly Glu  Arg Asn Ile 
    2315                 2320                 2325             


Ser Asn  Leu Asn Val Lys Lys  Thr His Arg Ile Ser  Val Val Asp 
    2330                 2335                 2340             


Thr Lys  Thr Gly Ser Glu Leu  Thr Val Tyr Glu Ala  Phe Gln Arg 
    2345                 2350                 2355             


Asn Leu  Ile Glu Lys Ser Ile  Tyr Leu Glu Leu Ser  Gly Gln Gln 
    2360                 2365                 2370             


Tyr Gln  Trp Lys Glu Ala Met  Phe Phe Glu Ser Tyr  Gly His Ser 
    2375                 2380                 2385             


Ser His  Met Leu Thr Asp Thr  Lys Thr Gly Leu His  Phe Asn Ile 
    2390                 2395                 2400             


Asn Glu  Ala Ile Glu Gln Gly  Thr Ile Asp Lys Ala  Leu Val Lys 
    2405                 2410                 2415             


Lys Tyr  Gln Glu Gly Leu Ile  Thr Leu Thr Glu Leu  Ala Asp Ser 
    2420                 2425                 2430             


Leu Leu  Ser Arg Leu Val Pro  Lys Lys Asp Leu His  Ser Pro Val 
    2435                 2440                 2445             


Ala Gly  Tyr Trp Leu Thr Ala  Ser Gly Glu Arg Ile  Ser Val Leu 
    2450                 2455                 2460             


Lys Ala  Ser Arg Arg Asn Leu  Val Asp Arg Ile Thr  Ala Leu Arg 
    2465                 2470                 2475             


Cys Leu  Glu Ala Gln Val Ser  Thr Gly Gly Ile Ile  Asp Pro Leu 
    2480                 2485                 2490             


Thr Gly  Lys Lys Tyr Arg Val  Ala Glu Ala Leu His  Arg Gly Leu 
    2495                 2500                 2505             


Val Asp  Glu Gly Phe Ala Gln  Gln Leu Arg Gln Cys  Glu Leu Val 
    2510                 2515                 2520             


Ile Thr  Gly Ile Gly His Pro  Ile Thr Asn Lys Met  Met Ser Val 
    2525                 2530                 2535             


Val Glu  Ala Val Asn Ala Asn  Ile Ile Asn Lys Glu  Met Gly Ile 
    2540                 2545                 2550             


Arg Cys  Leu Glu Phe Gln Tyr  Leu Thr Gly Gly Leu  Ile Glu Pro 
    2555                 2560                 2565             


Gln Val  His Ser Arg Leu Ser  Ile Glu Glu Ala Leu  Gln Val Gly 
    2570                 2575                 2580             


Ile Ile  Asp Val Leu Ile Ala  Thr Lys Leu Lys Asp  Gln Lys Ser 
    2585                 2590                 2595             


Tyr Val  Arg Asn Ile Ile Cys  Pro Gln Thr Lys Arg  Lys Leu Thr 
    2600                 2605                 2610             


Tyr Lys  Glu Ala Leu Glu Lys  Ala Asp Phe Asp Phe  His Thr Gly 
    2615                 2620                 2625             


Leu Lys  Leu Leu Glu Val Ser  Glu Pro Leu Met Thr  Gly Ile Ser 
    2630                 2635                 2640             


Ser Leu  Tyr Tyr Ser Ser 
    2645                 


<210>  3285
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSTN__Homo_sapiens__XP_011527445

<400>  3285

Met Ala Ser Gly Val Gln Val Ala Asp Glu Val Cys Arg Ile Phe Tyr 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile 
        35                  40                  45              


Val Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile 
    50                  55                  60                  


Thr Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys 
                85                  90                  95      


Glu Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe 
        115                 120                 125             


Gln Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn 
    130                 135                 140                 


Arg Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe 
145                 150                 155                 160 


Glu Gly Cys Pro Val 
                165 


<210>  3286
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSTYK__Homo_sapiens__NP_056190

<400>  3286

Met Glu Gly Asp Gly Val Pro Trp Gly Ser Glu Pro Val Ser Gly Pro 
1               5                   10                  15      


Gly Pro Gly Gly Gly Gly Met Ile Arg Glu Leu Cys Arg Gly Phe Gly 
            20                  25                  30          


Arg Tyr Arg Arg Tyr Leu Gly Arg Leu Arg Gln Asn Leu Arg Glu Thr 
        35                  40                  45              


Gln Lys Phe Phe Arg Asp Ile Lys Cys Ser His Asn His Thr Cys Leu 
    50                  55                  60                  


Ser Ser Leu Thr Gly Gly Gly Gly Ala Glu Arg Gly Pro Ala Gly Asp 
65                  70                  75                  80  


Val Ala Glu Thr Gly Leu Gln Ala Gly Gln Leu Ser Cys Ile Ser Phe 
                85                  90                  95      


Pro Pro Lys Glu Glu Lys Tyr Leu Gln Gln Ile Val Asp Cys Leu Pro 
            100                 105                 110         


Cys Ile Leu Ile Leu Gly Gln Asp Cys Asn Val Lys Cys Gln Leu Leu 
        115                 120                 125             


Asn Leu Leu Leu Gly Val Gln Val Leu Pro Thr Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Glu Ser Cys Lys Leu Arg Arg Leu Arg Phe Thr Tyr Gly Thr Gln 
145                 150                 155                 160 


Thr Arg Val Ser Leu Ala Leu Pro Gly Gln Tyr Glu Leu Val His Thr 
                165                 170                 175     


Leu Val Ala His Gln Gly Asn Trp Glu Thr Ile Pro Glu Glu Asp Leu 
            180                 185                 190         


Glu Val Gln Glu Asn Asn Glu Asp Ala Ala His Val Leu Ala Glu Leu 
        195                 200                 205             


Glu Val Thr Met His His Ala Leu Leu Gln Glu Val Asp Val Val Val 
    210                 215                 220                 


Ala Pro Cys Gln Gly Leu Arg Pro Thr Val Asp Val Leu Gly Asp Leu 
225                 230                 235                 240 


Val Asn Asp Phe Leu Pro Val Ile Thr Tyr Ala Leu His Lys Asp Glu 
                245                 250                 255     


Leu Ser Glu Arg Asp Glu Gln Glu Leu Gln Glu Ile Arg Lys Tyr Phe 
            260                 265                 270         


Ser Phe Pro Val Phe Phe Phe Lys Val Pro Lys Leu Gly Ser Glu Ile 
        275                 280                 285             


Ile Asp Ser Ser Thr Arg Arg Met Glu Ser Glu Arg Ser Pro Leu Tyr 
    290                 295                 300                 


Arg Gln Leu Ile Asp Leu Gly Tyr Leu Ser Ser Ser His Trp Asn Cys 
305                 310                 315                 320 


Gly Ala Pro Gly Gln Asp Thr Lys Ala Gln Ser Met Leu Val Glu Gln 
                325                 330                 335     


Ser Glu Lys Leu Arg His Leu Ser Thr Phe Ser His Gln Val Leu Gln 
            340                 345                 350         


Thr Arg Leu Val Asp Ala Ala Lys Ala Leu Asn Leu Val His Cys His 
        355                 360                 365             


Cys Leu Asp Ile Phe Ile Asn Gln Ala Phe Asp Met Gln Arg Asp Leu 
    370                 375                 380                 


Gln Ile Thr Pro Lys Arg Leu Glu Tyr Thr Arg Lys Lys Glu Asn Glu 
385                 390                 395                 400 


Leu Tyr Glu Ser Leu Met Asn Ile Ala Asn Arg Lys Gln Glu Glu Met 
                405                 410                 415     


Lys Asp Met Ile Val Glu Thr Leu Asn Thr Met Lys Glu Glu Leu Leu 
            420                 425                 430         


Asp Asp Ala Thr Asn Met Glu Phe Lys Asp Val Ile Val Pro Glu Asn 
        435                 440                 445             


Gly Glu Pro Val Gly Thr Arg Glu Ile Lys Cys Cys Ile Arg Gln Ile 
    450                 455                 460                 


Gln Glu Leu Ile Ile Ser Arg Leu Asn Gln Ala Val Ala Asn Lys Leu 
465                 470                 475                 480 


Ile Ser Ser Val Asp Tyr Leu Arg Glu Ser Phe Val Gly Thr Leu Glu 
                485                 490                 495     


Arg Cys Leu Gln Ser Leu Glu Lys Ser Gln Asp Val Ser Val His Ile 
            500                 505                 510         


Thr Ser Asn Tyr Leu Lys Gln Ile Leu Asn Ala Ala Tyr His Val Glu 
        515                 520                 525             


Val Thr Phe His Ser Gly Ser Ser Val Thr Arg Met Leu Trp Glu Gln 
    530                 535                 540                 


Ile Lys Gln Ile Ile Gln Arg Ile Thr Trp Val Ser Pro Pro Ala Ile 
545                 550                 555                 560 


Thr Leu Glu Trp Lys Arg Lys Val Ala Gln Glu Ala Ile Glu Ser Leu 
                565                 570                 575     


Ser Ala Ser Lys Leu Ala Lys Ser Ile Cys Ser Gln Phe Arg Thr Arg 
            580                 585                 590         


Leu Asn Ser Ser His Glu Ala Phe Ala Ala Ser Leu Arg Gln Leu Glu 
        595                 600                 605             


Ala Gly His Ser Gly Arg Leu Glu Lys Thr Glu Asp Leu Trp Leu Arg 
    610                 615                 620                 


Val Arg Lys Asp His Ala Pro Arg Leu Ala Arg Leu Ser Leu Glu Ser 
625                 630                 635                 640 


Cys Ser Leu Gln Asp Val Leu Leu His Arg Lys Pro Lys Leu Gly Gln 
                645                 650                 655     


Glu Leu Gly Arg Gly Gln Tyr Gly Val Val Tyr Leu Cys Asp Asn Trp 
            660                 665                 670         


Gly Gly His Phe Pro Cys Ala Leu Lys Ser Val Val Pro Pro Asp Glu 
        675                 680                 685             


Lys His Trp Asn Asp Leu Ala Leu Glu Phe His Tyr Met Arg Ser Leu 
    690                 695                 700                 


Pro Lys His Glu Arg Leu Val Asp Leu His Gly Ser Val Ile Asp Tyr 
705                 710                 715                 720 


Asn Tyr Gly Gly Gly Ser Ser Ile Ala Val Leu Leu Ile Met Glu Arg 
                725                 730                 735     


Leu His Arg Asp Leu Tyr Thr Gly Leu Lys Ala Gly Leu Thr Leu Glu 
            740                 745                 750         


Thr Arg Leu Gln Ile Ala Leu Asp Val Val Glu Gly Ile Arg Phe Leu 
        755                 760                 765             


His Ser Gln Gly Leu Val His Arg Asp Ile Lys Leu Lys Asn Val Leu 
    770                 775                 780                 


Leu Asp Lys Gln Asn Arg Ala Lys Ile Thr Asp Leu Gly Phe Cys Lys 
785                 790                 795                 800 


Pro Glu Ala Met Met Ser Gly Ser Ile Val Gly Thr Pro Ile His Met 
                805                 810                 815     


Ala Pro Glu Leu Phe Thr Gly Lys Tyr Asp Asn Ser Val Asp Val Tyr 
            820                 825                 830         


Ala Phe Gly Ile Leu Phe Trp Tyr Ile Cys Ser Gly Ser Val Lys Leu 
        835                 840                 845             


Pro Glu Ala Phe Glu Arg Cys Ala Ser Lys Asp His Leu Trp Asn Asn 
    850                 855                 860                 


Val Arg Arg Gly Ala Arg Pro Glu Arg Leu Pro Val Phe Asp Glu Glu 
865                 870                 875                 880 


Cys Trp Gln Leu Met Glu Ala Cys Trp Asp Gly Asp Pro Leu Lys Arg 
                885                 890                 895     


Pro Leu Leu Gly Ile Val Gln Pro Met Leu Gln Gly Ile Met Asn Arg 
            900                 905                 910         


Leu Cys Lys Ser Asn Ser Glu Gln Pro Asn Arg Gly Leu Asp Asp Ser 
        915                 920                 925             


Thr 
    


<210>  3287
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTD1__Homo_sapiens__NP_543010

<400>  3287

Met Lys Ala Val Val Gln Arg Val Thr Arg Ala Ser Val Thr Val Gly 
1               5                   10                  15      


Gly Glu Gln Ile Ser Ala Ile Gly Arg Gly Ile Cys Val Leu Leu Gly 
            20                  25                  30          


Ile Ser Leu Glu Asp Thr Gln Lys Glu Leu Glu His Met Val Arg Lys 
        35                  40                  45              


Ile Leu Asn Leu Arg Val Phe Glu Asp Glu Ser Gly Lys His Trp Ser 
    50                  55                  60                  


Lys Ser Val Met Asp Lys Gln Tyr Glu Ile Leu Cys Val Ser Gln Phe 
65                  70                  75                  80  


Thr Leu Gln Cys Val Leu Lys Gly Asn Lys Pro Asp Phe His Leu Ala 
                85                  90                  95      


Met Pro Thr Glu Gln Ala Glu Gly Phe Tyr Asn Ser Phe Leu Glu Gln 
            100                 105                 110         


Leu Arg Lys Thr Tyr Arg Pro Glu Leu Ile Lys Asp Gly Lys Phe Gly 
        115                 120                 125             


Ala Tyr Met Gln Val His Ile Gln Asn Asp Gly Pro Val Thr Ile Glu 
    130                 135                 140                 


Leu Glu Ser Pro Ala Pro Gly Thr Ala Thr Ser Asp Pro Lys Gln Leu 
145                 150                 155                 160 


Ser Lys Leu Glu Lys Gln Gln Gln Arg Lys Glu Lys Thr Arg Ala Lys 
                165                 170                 175     


Gly Pro Ser Glu Ser Ser Lys Glu Arg Asn Thr Pro Arg Lys Glu Asp 
            180                 185                 190         


Arg Ser Ala Ser Ser Gly Ala Glu Gly Asp Val Ser Ser Glu Arg Glu 
        195                 200                 205             


Pro 
    


<210>  3288
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTHD1__Homo_sapiens__NP_001130008

<400>  3288

Met Cys Leu Glu Lys Arg Tyr Leu Asp Val Leu Ser Asp Val Thr Gly 
1               5                   10                  15      


Pro Gln Val Ser Cys Tyr Ile Thr Ala Pro Ser Tyr Val Leu Gln Gln 
            20                  25                  30          


Leu Glu Cys Arg Ile Ile Asn His Met Ser Ser Leu Ile Val Gly Asp 
        35                  40                  45              


Asn Glu Glu Leu Val Ser Asn Val Ile Thr Ile Glu Cys Ser Asp Lys 
    50                  55                  60                  


Glu Lys Arg Val Pro Phe Pro Ile Gly Ile Ala Ile Pro Phe Thr Ala 
65                  70                  75                  80  


Arg Tyr Arg Gly Asn Tyr Arg Asp Ile Met Val Lys Val Cys Asp Ile 
                85                  90                  95      


Asn Leu Gln Ser Ser Tyr Leu Asn Pro Asn Ser Leu Glu Gly Met Lys 
            100                 105                 110         


Gly Gly Tyr Lys Gly Thr Cys Ala Ser Val Lys Val Tyr Lys Leu Gly 
        115                 120                 125             


Ile Phe Ser Val Val Ser Cys Leu Lys Lys Glu Ser Phe Thr Val Thr 
    130                 135                 140                 


Lys Lys Gly Leu Ala Leu Lys Ser Ser Met Asp Ser Arg Ile Ser Leu 
145                 150                 155                 160 


Asn Tyr Pro Pro Gly Val Phe Thr Ser Pro Val Leu Val Gln Leu Lys 
                165                 170                 175     


Ile Gln Pro Val Asp Pro Ala Leu Val Ala His Leu Lys Ala Gln Gln 
            180                 185                 190         


Asp Thr Phe Tyr Ser Val Gln Ser Thr Ser Pro Leu Ile His Ile Gln 
        195                 200                 205             


His Pro Ser Thr Tyr Pro Phe Gln Lys Pro Val Thr Leu Phe Leu Pro 
    210                 215                 220                 


Cys Ser Pro Tyr Leu Asp Lys Asn Asn Leu Gly Ser Glu Ile Asp His 
225                 230                 235                 240 


Lys Arg Arg Ala Ser Ala Thr Ile Asn Arg Ile Thr Pro Ser Tyr Phe 
                245                 250                 255     


Asn Arg Thr Lys Ile Ala Ser Ile Arg Lys Pro Arg Lys Asn Ala Ser 
            260                 265                 270         


Glu Cys Leu Lys Leu Leu Gly Phe Arg Ser Gln Asp Ser Gly Trp Cys 
        275                 280                 285             


Gly Leu Asp Asp Val Val Lys Thr Ile Gln Ser Gly Leu Val Ser Val 
    290                 295                 300                 


Glu Leu Tyr Glu His Leu Glu Arg Phe Ile Val Leu His Leu Ser Ser 
305                 310                 315                 320 


Thr Met Asp Asn Ser His Leu Val Thr Phe Val Lys Ser Leu Glu Glu 
                325                 330                 335     


Ala Met Leu Ser Thr Thr Ala Cys Ile Val Leu Ser His Gln Lys Asp 
            340                 345                 350         


Asn Pro His Arg Ile Ala Val Leu Val Val Pro Ser Lys Asp Leu Ser 
        355                 360                 365             


Gln Val Leu Lys Asp Leu His Leu Glu Gly Phe Gly Gly Pro Pro Glu 
    370                 375                 380                 


Pro Ser Arg His Phe Gln Val Arg Glu Gly Glu Gln Leu Leu Leu Arg 
385                 390                 395                 400 


Phe Thr Gly Asn Ile Phe Ala Ser Ser Asn Gly Lys Asp Tyr Gly Lys 
                405                 410                 415     


Asp Tyr Thr Leu Ile Phe His Leu Gln Arg Lys Pro Arg Leu Glu Leu 
            420                 425                 430         


Gln Ile Lys Glu Val Asp Glu Phe Gly Asn Tyr Ser Cys Pro His Tyr 
        435                 440                 445             


Lys Gly Thr Ile Val Val Tyr Lys Val Pro Lys Gly Lys Ile Val Pro 
    450                 455                 460                 


Asn Leu Asn Gln Ser Leu Val Ile Asn Glu Asn His Ser Gln Leu Pro 
465                 470                 475                 480 


Ile Cys Lys Leu Pro Leu Lys Leu Pro Lys His Lys Lys Leu Ile Asn 
                485                 490                 495     


Arg Pro Gln Ser Thr Lys Arg Val Ser Lys Asp Pro Val Glu Ala Leu 
            500                 505                 510         


Trp Asp Asn Leu Leu His Trp Leu Ala Glu Glu Leu Ser Glu Glu Asn 
        515                 520                 525             


Ala Glu Ser Leu Ser Ser Thr Leu Pro Leu Arg Arg Ser Thr Ile Gln 
    530                 535                 540                 


Leu Ile Lys Leu Lys Asn Pro Asp Asp Leu Thr Glu Gln Ile His Glu 
545                 550                 555                 560 


Phe Leu Cys Phe Trp Lys Lys Ser Leu Pro Thr Phe Thr Asp Lys Leu 
                565                 570                 575     


Arg Leu Leu Ala Arg His Leu Arg Lys Ile Gly Arg Ser Asp Leu Ala 
            580                 585                 590         


Glu Glu Leu Lys Phe Lys Trp Glu Asn Lys Val Phe Thr Glu Pro Gln 
        595                 600                 605             


Gln Cys Phe Asp Val Ala Pro Glu 
    610                 615     


<210>  3289
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTL__Homo_sapiens__NP_001273158

<400>  3289

Met Gly Tyr Ser Ser Leu Ile Leu Asp Ser Thr Gly Ser Thr Leu Phe 
1               5                   10                  15      


Ala Asn Cys Thr Asp Asp Asn Ile Tyr Met Phe Asn Met Thr Gly Leu 
            20                  25                  30          


Lys Thr Ser Pro Val Ala Ile Phe Asn Gly His Gln Asn Ser Thr Phe 
        35                  40                  45              


Tyr Val Lys Ser Ser Leu Ser Pro Asp Asp Gln Phe Leu Val Ser Gly 
    50                  55                  60                  


Ser Ser Asp Glu Ala Ala Tyr Ile Trp Lys Val Ser Thr Pro Trp Gln 
65                  70                  75                  80  


Pro Pro Thr Val Leu Leu Gly His Ser Gln Glu Val Thr Ser Val Cys 
                85                  90                  95      


Trp Cys Pro Ser Asp Phe Thr Lys Ile Ala Thr Cys Ser Asp Asp Asn 
            100                 105                 110         


Thr Leu Lys Ile Trp Arg Leu Asn Arg Gly Leu Glu Glu Lys Pro Gly 
        115                 120                 125             


Gly Asp Lys Leu Ser Thr Val Gly Trp Ala Ser Gln Lys Lys Lys Glu 
    130                 135                 140                 


Ser Arg Pro Gly Leu Val Thr Val Thr Ser Ser Gln Ser Thr Pro Ala 
145                 150                 155                 160 


Lys Ala Pro Arg Val Lys Cys Asn Pro Ser Asn Ser Ser Pro Ser Ser 
                165                 170                 175     


Ala Ala Cys Ala Pro Ser Cys Ala Gly Asp Leu Pro Leu Pro Ser Asn 
            180                 185                 190         


Thr Pro Thr Phe Ser Ile Lys Thr Ser Pro Ala Lys Ala Arg Ser Pro 
        195                 200                 205             


Ile Asn Arg Arg Gly Ser Val Ser Ser Val Ser Pro Lys Pro Pro Ser 
    210                 215                 220                 


Ser Phe Lys Met Ser Ile Arg Asn Trp Val Thr Arg Thr Pro Ser Ser 
225                 230                 235                 240 


Ser Pro Pro Ile Thr Pro Pro Ala Ser Glu Thr Lys Ile Met Ser Pro 
                245                 250                 255     


Arg Lys Ala Leu Ile Pro Val Ser Gln Lys Ser Ser Gln Ala Glu Ala 
            260                 265                 270         


Cys Ser Glu Ser Arg Asn Arg Val Lys Arg Arg Leu Asp Ser Ser Cys 
        275                 280                 285             


Leu Glu Ser Val Lys Gln Lys Cys Val Lys Ser Cys Asn Cys Val Thr 
    290                 295                 300                 


Glu Leu Asp Gly Gln Val Glu Asn Leu His Leu Asp Leu Cys Cys Leu 
305                 310                 315                 320 


Ala Gly Asn Gln Glu Asp Leu Ser Lys Asp Ser Leu Gly Pro Thr Lys 
                325                 330                 335     


Ser Ser Lys Ile Glu Gly Ala Gly Thr Ser Ile Ser Glu Pro Pro Ser 
            340                 345                 350         


Pro Ile Ser Pro Tyr Ala Ser Glu Ser Cys Gly Thr Leu Pro Leu Pro 
        355                 360                 365             


Leu Arg Pro Cys Gly Glu Gly Ser Glu Met Val Gly Lys Glu Asn Ser 
    370                 375                 380                 


Ser Pro Glu Asn Lys Asn Trp Leu Leu Ala Met Ala Ala Lys Arg Lys 
385                 390                 395                 400 


Ala Glu Asn Pro Ser Pro Arg Ser Pro Ser Ser Gln Thr Pro Asn Ser 
                405                 410                 415     


Arg Arg Gln Ser Gly Lys Thr Leu Pro Ser Pro Val Thr Ile Thr Pro 
            420                 425                 430         


Ser Ser Met Arg Lys Ile Cys Thr Tyr Phe His Arg Lys Ser Gln Glu 
        435                 440                 445             


Asp Phe Cys Gly Pro Glu His Ser Thr Glu Leu 
    450                 455                 


<210>  3290
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTNA__Homo_sapiens__NP_001121647

<400>  3290

Met Ile Glu Asp Ser Gly Lys Arg Gly Asn Thr Met Ala Glu Arg Arg 
1               5                   10                  15      


Gln Leu Phe Ala Glu Met Arg Ala Gln Asp Leu Asp Arg Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Lys Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Val Ile Glu Ala Leu Arg Glu 
    50                  55                  60                  


Asn Ala Leu Asn Asn Leu Asp Pro Asn Thr Glu Leu Asn Val Ser Arg 
65                  70                  75                  80  


Leu Glu Ala Val Leu Ser Thr Ile Phe Tyr Gln Leu Asn Lys Arg Met 
                85                  90                  95      


Pro Thr Thr His Gln Ile His Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Leu Leu Ala Ala Phe Asp Pro Glu Gly His Gly Lys Ile Ser 
        115                 120                 125             


Val Phe Ala Val Lys Met Ala Leu Ala Thr Leu Cys Gly Gly Lys Ile 
    130                 135                 140                 


Met Asp Lys Leu Arg Tyr Ile Phe Ser Met Ile Ser Asp Ser Ser Gly 
145                 150                 155                 160 


Val Met Val Tyr Gly Arg Tyr Asp Gln Phe Leu Arg Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu Gln 
            180                 185                 190         


Ser Ala Arg Ser Cys Phe Ser Gln Gln Lys Lys Val Thr Leu Asn Gly 
        195                 200                 205             


Phe Leu Asp Thr Leu Met Ser Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Leu His Arg Leu Ala Asn Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys His Ser Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asp Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Ser His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


Tyr Thr Ser Trp Lys Ser Pro Ala Lys Lys Leu Thr Asn Ala Leu Ser 
    290                 295                 300                 


Lys Ser Leu Ser Cys Ala Ser Ser Arg Glu Pro Leu His Pro Met Phe 
305                 310                 315                 320 


Pro Asp Gln Pro Glu Lys Pro Leu Asn Leu Ala His Ile Val Pro Pro 
                325                 330                 335     


Arg Pro Val Thr Ser Met Asn Asp Thr Leu Phe Ser His Ser Val Pro 
            340                 345                 350         


Ser Ser Gly Ser Pro Phe Ile Thr Arg Ser Ser Asp Gly Ala Phe Gly 
        355                 360                 365             


Gly Cys Val 
    370     


<210>  3291
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTNB__Homo_sapiens__NP_001243232

<400>  3291

Met Ile Glu Glu Ser Gly Asn Lys Arg Lys Thr Met Ala Glu Lys Arg 
1               5                   10                  15      


Gln Leu Phe Ile Glu Met Arg Ala Gln Asn Phe Asp Val Ile Arg Leu 
            20                  25                  30          


Ser Thr Tyr Arg Thr Ala Cys Lys Leu Arg Phe Val Gln Lys Arg Cys 
        35                  40                  45              


Asn Leu His Leu Val Asp Ile Trp Asn Met Ile Glu Ala Phe Arg Asp 
    50                  55                  60                  


Asn Gly Leu Asn Thr Leu Asp His Thr Thr Glu Ile Ser Val Ser Arg 
65                  70                  75                  80  


Leu Glu Thr Val Ile Ser Ser Ile Tyr Tyr Gln Leu Asn Lys Arg Leu 
                85                  90                  95      


Pro Ser Thr His Gln Ile Ser Val Glu Gln Ser Ile Ser Leu Leu Leu 
            100                 105                 110         


Asn Phe Met Ile Ala Ala Tyr Asp Ser Glu Gly Arg Gly Lys Leu Thr 
        115                 120                 125             


Val Phe Ser Val Lys Ala Met Leu Ala Thr Met Cys Gly Gly Lys Met 
    130                 135                 140                 


Leu Asp Lys Leu Arg Tyr Val Phe Ser Gln Met Ser Asp Ser Asn Gly 
145                 150                 155                 160 


Leu Met Ile Phe Ser Lys Phe Asp Gln Phe Leu Lys Glu Val Leu Lys 
                165                 170                 175     


Leu Pro Thr Ala Val Phe Glu Gly Pro Ser Phe Gly Tyr Thr Glu His 
            180                 185                 190         


Ser Val Arg Thr Cys Phe Pro Gln Gln Arg Lys Ile Met Leu Asn Met 
        195                 200                 205             


Phe Leu Asp Thr Met Met Ala Asp Pro Pro Pro Gln Cys Leu Val Trp 
    210                 215                 220                 


Leu Pro Leu Met His Arg Leu Ala His Val Glu Asn Val Phe His Pro 
225                 230                 235                 240 


Val Glu Cys Ser Tyr Cys Arg Cys Glu Ser Met Met Gly Phe Arg Tyr 
                245                 250                 255     


Arg Cys Gln Gln Cys His Asn Tyr Gln Leu Cys Gln Asn Cys Phe Trp 
            260                 265                 270         


Arg Gly His Ala Gly Gly Pro His Ser Asn Gln His Gln Met Lys Glu 
        275                 280                 285             


His Ser Ser Trp Lys Ser Pro Ala Lys Lys Leu Ser His Ala Ile Ser 
    290                 295                 300                 


Lys Ser Leu Gly Cys Val Pro Thr Arg Glu Pro Pro His Pro Val Phe 
305                 310                 315                 320 


Pro Glu Gln Pro Glu Lys Pro Leu Asp Leu Ala His Ile Val Pro Pro 
                325                 330                 335     


Arg Pro Leu Thr Asn Met Asn Asp Thr Met Val Ser His Met Ser Ser 
            340                 345                 350         


Gly Val Pro Thr Pro Thr Lys Arg Leu Gln Tyr Ser Gln Asp Ile Pro 
        355                 360                 365             


Ser His Leu Ala Asp Glu His Ala Leu Ile Ala Ser Tyr Val Ala Arg 
    370                 375                 380                 


Leu Gln His Cys Ala Arg Val Leu Asp Ser Pro Ser Arg Leu Asp Glu 
385                 390                 395                 400 


Glu His Arg Leu Ile Ala Arg Tyr Ala Ala Arg Leu Ala Ala Glu Ala 
                405                 410                 415     


Gly Asn Val Thr Arg Pro Pro Thr Asp Leu Ser Phe Asn Phe Asp Ala 
            420                 425                 430         


Asn Lys Gln Gln Arg Gln Leu Ile Ala Glu Leu Glu Asn Lys Asn Arg 
        435                 440                 445             


Glu Ile Leu Gln Glu Ile Gln Arg Leu Arg Leu Glu His Glu Gln Ala 
    450                 455                 460                 


Ser Gln Pro Thr Pro Glu Lys Ala Gln Gln Asn Pro Thr Leu Leu Ala 
465                 470                 475                 480 


Glu Leu Arg Leu Leu Arg Gln Arg Lys Asp Glu Leu Glu Gln Arg Met 
                485                 490                 495     


Ser Ala Leu Gln Glu Ser Arg Arg Glu Leu Met Val Gln Leu Glu Glu 
            500                 505                 510         


Leu Met Lys Leu Leu Lys Ala Gln Ala Thr Gly Ser Pro His Thr Ser 
        515                 520                 525             


Pro Thr His Gly Gly Gly Arg Pro Met Pro Met Pro Val Arg Ser Thr 
    530                 535                 540                 


Ser Ala Gly Ser Thr Pro Thr His Cys Pro Gln Asp Ser Leu Ser Gly 
545                 550                 555                 560 


Val Gly Gly Asp Val Gln Glu Ala Phe Ala Gln Gly Thr Arg Arg Asn 
                565                 570                 575     


Leu Arg Asn Asp Leu Leu Val Ala Ala Asp Ser Ile Thr Asn Thr Met 
            580                 585                 590         


Ser Ser Leu Val Lys Glu Leu His Ser Ala Glu Glu Gly Ala Glu Glu 
        595                 600                 605             


Glu Glu Glu Lys Met Gln Asn Gly Lys Asp Arg Gly 
    610                 615                 620 


<210>  3292
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTNBP1__Homo_sapiens__NP_001258596

<400>  3292

Met Leu Ser Ala His Trp Glu Lys Lys Lys Thr Ser Leu Val Glu Leu 
1               5                   10                  15      


Gln Glu Gln Leu Gln Gln Leu Pro Ala Leu Ile Ala Asp Leu Glu Ser 
            20                  25                  30          


Met Thr Ala Asn Leu Thr His Leu Glu Ala Ser Phe Glu Glu Val Glu 
        35                  40                  45              


Asn Asn Leu Leu His Leu Glu Asp Leu Cys Gly Gln Cys Glu Leu Glu 
    50                  55                  60                  


Arg Cys Lys His Met Gln Ser Gln Gln Leu Glu Asn Tyr Lys Lys Asn 
65                  70                  75                  80  


Lys Arg Lys Glu Leu Glu Thr Phe Lys Ala Glu Leu Asp Ala Glu His 
                85                  90                  95      


Ala Gln Lys Val Leu Glu Met Glu His Thr Gln Gln Met Lys Leu Lys 
            100                 105                 110         


Glu Arg Gln Lys Phe Phe Glu Glu Ala Phe Gln Gln Asp Met Glu Gln 
        115                 120                 125             


Tyr Leu Ser Thr Gly Tyr Leu Gln Ile Ala Glu Arg Arg Glu Pro Ile 
    130                 135                 140                 


Gly Ser Met Ser Ser Met Glu Val Asn Val Asp Met Leu Glu Gln Met 
145                 150                 155                 160 


Asp Leu Met Asp Ile Ser Asp Gln Glu Ala Leu Asp Val Phe Leu Asn 
                165                 170                 175     


Ser Gly Gly Glu Glu Asn Thr Val Leu Ser Pro Ala Leu Gly Pro Glu 
            180                 185                 190         


Ser Ser Thr Cys Gln Asn Glu Ile Thr Leu Gln Val Pro Asn Pro Ser 
        195                 200                 205             


Glu Leu Arg Ala Lys Pro Pro Ser Ser Ser Ser Thr Cys Thr Asp Ser 
    210                 215                 220                 


Ala Thr Arg Asp Ile Ser Glu Gly Gly Glu Ser Pro Val Val Gln Ser 
225                 230                 235                 240 


Asp Glu Glu Glu Val Gln Val Asp Thr Ala Leu Ala Thr Ser His Thr 
                245                 250                 255     


Asp Arg Glu Ala Thr Pro Asp Gly Gly Glu Asp Ser Asp Ser 
            260                 265                 270 


<210>  3293
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTX1__Homo_sapiens__XP_011536311

<400>  3293

Met Ser Arg Pro Gly His Gly Gly Leu Met Pro Val Asn Gly Leu Gly 
1               5                   10                  15      


Phe Pro Pro Gln Asn Val Ala Arg Val Val Val Trp Glu Trp Leu Asn 
            20                  25                  30          


Glu His Ser Arg Trp Arg Pro Tyr Thr Ala Thr Val Cys His His Ile 
        35                  40                  45              


Glu Asn Val Leu Lys Glu Asp Ala Arg Gly Ser Val Val Leu Gly Gln 
    50                  55                  60                  


Val Asp Ala Gln Leu Val Pro Tyr Ile Ile Asp Leu Gln Ser Met His 
65                  70                  75                  80  


Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Pro Val Arg Arg Asn Phe 
                85                  90                  95      


Tyr Asp Pro Ser Ser Ala Pro Gly Lys Gly Ile Val Trp Glu Trp Glu 
            100                 105                 110         


Asn Asp Gly Gly Ala Trp Thr Ala Tyr Asp Met Asp Ile Cys Ile Thr 
        115                 120                 125             


Ile Gln Asn Ala Tyr Glu Lys Gln His Pro Trp Leu Asp Leu Ser Ser 
    130                 135                 140                 


Leu Gly Phe Cys Tyr Leu Ile Tyr Phe Asn Ser Met Ser Gln Met Asn 
145                 150                 155                 160 


Arg Gln Thr Arg Arg Arg Arg Arg Leu Arg Arg Arg Leu Asp Leu Ala 
                165                 170                 175     


Tyr Pro Leu Thr Val Gly Ser Ile Pro Lys Ser Gln Ser Trp Pro Val 
            180                 185                 190         


Gly Ala Ser Ser Gly Gln Pro Cys Ser Cys Gln Gln Cys Leu Leu Val 
        195                 200                 205             


Asn Ser Thr Arg Ala Ala Ser Asn Ala Ile Leu Ala Ser Gln Arg Arg 
    210                 215                 220                 


Lys Ala Pro Pro Ala Pro Pro Leu Pro Pro Pro Pro Pro Pro Gly Gly 
225                 230                 235                 240 


Pro Pro Gly Ala Leu Ala Val Arg Pro Ser Ala Thr Phe Thr Gly Ala 
                245                 250                 255     


Ala Leu Trp Ala Ala Pro Ala Ala Gly Pro Ala Glu Pro Ala Pro Pro 
            260                 265                 270         


Pro Gly Ala Pro Pro Arg Ser Pro Gly Ala Pro Gly Gly Ala Arg Thr 
        275                 280                 285             


Pro Gly Gln Asn Asn Leu Asn Arg Pro Gly Pro Gln Arg Thr Thr Ser 
    290                 295                 300                 


Val Ser Ala Arg Ala Ser Ile Pro Pro Gly Val Pro Ala Leu Pro Val 
305                 310                 315                 320 


Lys Asn Leu Asn Gly Thr Gly Pro Val His Pro Ala Leu Ala Gly Met 
                325                 330                 335     


Thr Gly Ile Leu Leu Cys Ala Ala Gly Leu Pro Val Cys Leu Thr Arg 
            340                 345                 350         


Ala Pro Lys Pro Ile Leu His Pro Pro Pro Val Ser Lys Ser Asp Val 
        355                 360                 365             


Lys Pro Val Pro Gly Val Pro Gly Val Cys Arg Lys Thr Lys Lys Lys 
    370                 375                 380                 


His Leu Lys Lys Ser Lys Asn Pro Glu Asp Val Val Arg Arg Tyr Met 
385                 390                 395                 400 


Gln Lys Val Lys Asn Pro Pro Asp Glu Asp Cys Thr Ile Cys Met Glu 
                405                 410                 415     


Arg Leu Val Thr Ala Ser Gly Tyr Glu Gly Val Leu Arg His Lys Gly 
            420                 425                 430         


Val Arg Pro Glu Leu Val Gly Arg Leu Gly Arg Cys Gly His Met Tyr 
        435                 440                 445             


His Leu Leu Cys Leu Val Ala Met Tyr Ser Asn Gly Asn Lys Asp Gly 
    450                 455                 460                 


Ser Leu Gln Cys Pro Thr Cys Lys Ala Ile Tyr Gly Glu Lys Thr Gly 
465                 470                 475                 480 


Thr Gln Pro Pro Gly Lys Met Glu Phe His Leu Ile Pro His Ser Leu 
                485                 490                 495     


Pro Gly Phe Pro Asp Thr Gln Thr Ile Arg Ile Val Tyr Asp Ile Pro 
            500                 505                 510         


Thr Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Lys Phe Thr 
        515                 520                 525             


Ala Arg Gly Phe Pro Arg His Cys Tyr Leu Pro Asn Asn Glu Lys Gly 
    530                 535                 540                 


Arg Lys Val Leu Arg Leu Leu Ile Thr Ala Trp Glu Arg Arg Leu Ile 
545                 550                 555                 560 


Phe Thr Ile Gly Thr Ser Asn Thr Thr Gly Glu Ser Asp Thr Val Val 
                565                 570                 575     


Trp Asn Glu Ile His His Lys Thr Glu Phe Gly Ser Asn Leu Thr Gly 
            580                 585                 590         


His Gly Tyr Pro Asp Ala Ser Tyr Leu Asp Asn Val Leu Ala Glu Leu 
        595                 600                 605             


Thr Ala Gln Gly Val Ser Glu Ala Ala Ala Lys Ala 
    610                 615                 620 


<210>  3294
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTX2__Homo_sapiens__NP_001096064

<400>  3294

Met Ala Met Ala Pro Ser Pro Ser Leu Val Gln Val Tyr Thr Ser Pro 
1               5                   10                  15      


Ala Ala Val Ala Val Trp Glu Trp Gln Asp Gly Leu Gly Thr Trp His 
            20                  25                  30          


Pro Tyr Ser Ala Thr Val Cys Ser Phe Ile Glu Gln Gln Phe Val Gln 
        35                  40                  45              


Gln Lys Gly Gln Arg Phe Gly Leu Gly Ser Leu Ala His Ser Ile Pro 
    50                  55                  60                  


Leu Gly Gln Ala Asp Pro Ser Leu Ala Pro Tyr Ile Ile Asp Leu Pro 
65                  70                  75                  80  


Ser Trp Thr Gln Phe Arg Gln Asp Thr Gly Thr Met Arg Ala Val Arg 
                85                  90                  95      


Arg His Leu Phe Pro Gln His Ser Ala Pro Gly Arg Gly Val Val Trp 
            100                 105                 110         


Glu Trp Leu Ser Asp Asp Gly Ser Trp Thr Ala Tyr Glu Ala Ser Val 
        115                 120                 125             


Cys Asp Tyr Leu Glu Gln Gln Val Ala Arg Gly Asn Gln Leu Val Asp 
    130                 135                 140                 


Leu Ala Pro Leu Gly Tyr Asn Tyr Thr Val Asn Tyr Thr Thr His Thr 
145                 150                 155                 160 


Gln Thr Asn Lys Thr Ser Ser Phe Cys Arg Ser Val Arg Arg Gln Ala 
                165                 170                 175     


Gly Pro Pro Tyr Pro Val Thr Thr Ile Ile Ala Pro Pro Gly His Thr 
            180                 185                 190         


Gly Val Ala Cys Ser Cys His Gln Cys Leu Ser Gly Ser Arg Thr Gly 
        195                 200                 205             


Pro Val Ser Gly Arg Tyr Arg His Ser Met Thr Asn Leu Pro Ala Tyr 
    210                 215                 220                 


Pro Val Pro Gln His Pro Pro His Arg Thr Ala Ser Val Phe Gly Thr 
225                 230                 235                 240 


His Gln Ala Phe Ala Pro Tyr Asn Lys Pro Ser Leu Ser Gly Ala Arg 
                245                 250                 255     


Ser Ala Pro Arg Leu Asn Thr Thr Asn Ala Trp Gly Ala Ala Pro Pro 
            260                 265                 270         


Ser Leu Gly Ser Gln Pro Leu Tyr Arg Ser Ser Leu Ser His Leu Gly 
        275                 280                 285             


Pro Gln His Leu Pro Pro Gly Ser Ser Thr Ser Gly Ala Val Ser Ala 
    290                 295                 300                 


Ser Leu Pro Ser Gly Pro Ser Ser Ser Pro Gly Ser Val Pro Ala Thr 
305                 310                 315                 320 


Val Pro Met Gln Met Pro Lys Pro Ser Arg Val Gln Gln Ala Leu Ala 
                325                 330                 335     


Gly Met Thr Ser Val Leu Met Ser Ala Ile Gly Leu Pro Val Cys Leu 
            340                 345                 350         


Ser Arg Ala Pro Gln Pro Thr Ser Pro Pro Ala Ser Arg Leu Ala Ser 
        355                 360                 365             


Lys Ser His Gly Ser Val Lys Arg Leu Arg Lys Met Ser Val Lys Gly 
    370                 375                 380                 


Ala Thr Pro Lys Pro Glu Pro Glu Pro Glu Gln Val Ile Lys Asn Tyr 
385                 390                 395                 400 


Thr Glu Glu Leu Lys Val Pro Pro Asp Glu Asp Cys Ile Ile Cys Met 
                405                 410                 415     


Glu Lys Leu Ser Thr Ala Ser Gly Tyr Ser Asp Val Thr Asp Ser Lys 
            420                 425                 430         


Ala Ile Gly Ser Leu Ala Val Gly His Leu Thr Lys Cys Ser His Ala 
        435                 440                 445             


Phe His Leu Leu Cys Leu Leu Ala Met Tyr Cys Asn Gly Asn Lys Asp 
    450                 455                 460                 


Gly Ser Leu Gln Cys Pro Ser Cys Lys Thr Ile Tyr Gly Glu Lys Thr 
465                 470                 475                 480 


Gly Thr Gln Pro Gln Gly Lys Met Glu Val Leu Arg Phe Gln Met Ser 
                485                 490                 495     


Leu Pro Gly His Glu Asp Cys Gly Thr Ile Leu Ile Val Tyr Ser Ile 
            500                 505                 510         


Pro His Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Pro Phe 
        515                 520                 525             


Thr Ala Arg Gly Phe Pro Arg Gln Cys Tyr Leu Pro Asp Asn Ala Gln 
    530                 535                 540                 


Gly Arg Lys Val Leu Glu Leu Leu Lys Val Ala Trp Lys Arg Arg Leu 
545                 550                 555                 560 


Ile Phe Thr Val Gly Thr Ser Ser Thr Thr Gly Glu Thr Asp Thr Val 
                565                 570                 575     


Val Trp Asn Glu Ile His His Lys Thr Glu Met Asp Arg Asn Ile Thr 
            580                 585                 590         


Gly His Gly Tyr Pro Asp Pro Asn Tyr Leu Gln Asn Val Leu Ala Glu 
        595                 600                 605             


Leu Ala Ala Gln Gly Val Thr Glu Asp Cys Leu Glu Gln Gln 
    610                 615                 620         


<210>  3295
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTX3__Homo_sapiens__NP_001273174

<400>  3295

Met Pro Ile Leu Ser Ser Ser Gly Ser Lys Met Ala Ala Cys Gly Gly 
1               5                   10                  15      


Thr Cys Lys Asn Lys Val Thr Val Ser Lys Pro Val Trp Asp Phe Leu 
            20                  25                  30          


Ser Lys Glu Thr Pro Ala Arg Leu Ala Arg Leu Arg Glu Glu His Arg 
        35                  40                  45              


Val Ser Ile Leu Ile Asp Gly Glu Thr Ser Asp Ile Tyr Val Leu Gln 
    50                  55                  60                  


Leu Ser Pro Gln Gly Pro Pro Pro Ala Pro Pro Asn Gly Leu Tyr Leu 
65                  70                  75                  80  


Ala Arg Lys Ala Leu Lys Gly Leu Leu Lys Glu Ala Glu Lys Glu Leu 
                85                  90                  95      


Lys Lys Ala Gln Arg Gln Gly Glu Leu Met Gly Cys Leu Ala Leu Gly 
            100                 105                 110         


Gly Gly Gly Glu His Pro Glu Met His Arg Ala Gly Pro Pro Pro Leu 
        115                 120                 125             


Arg Ala Ala Pro Leu Leu Pro Pro Gly Ala Arg Gly Leu Pro Pro Pro 
    130                 135                 140                 


Pro Pro Pro Leu Pro Pro Pro Leu Pro Pro Arg Leu Arg Glu Glu Ala 
145                 150                 155                 160 


Glu Glu Gln Glu Ser Thr Cys Pro Ile Cys Leu Gly Glu Ile Gln Asn 
                165                 170                 175     


Ala Lys Thr Leu Glu Lys Cys Arg His Ser Phe Cys Glu Gly Cys Ile 
            180                 185                 190         


Thr Arg Ala Leu Gln Val Lys Lys Ala Cys Pro Met Cys Gly Arg Phe 
        195                 200                 205             


Tyr Gly Gln Leu Val Gly Asn Gln Pro Gln Asn Gly Arg Met Leu Val 
    210                 215                 220                 


Ser Lys Asp Ala Thr Leu Leu Leu Pro Ser Tyr Glu Lys Tyr Gly Thr 
225                 230                 235                 240 


Ile Val Ile Gln Tyr Val Phe Pro Pro Gly Val Gln Gly Ala Glu His 
                245                 250                 255     


Pro Asn Pro Gly Val Arg Tyr Pro Gly Thr Thr Arg Val Ala Tyr Leu 
            260                 265                 270         


Pro Asp Cys Pro Glu Gly Asn Lys Val Leu Thr Leu Phe Arg Lys Ala 
        275                 280                 285             


Phe Asp Gln Arg Leu Thr Phe Thr Ile Gly Thr Ser Met Thr Thr Gly 
    290                 295                 300                 


Arg Pro Asn Val Ile Thr Trp Asn Asp Ile His His Lys Thr Ser Cys 
305                 310                 315                 320 


Thr Gly Gly Pro Gln Leu Phe Gly Tyr Pro Asp Pro Thr Tyr Leu Thr 
                325                 330                 335     


Arg Val Gln Glu Glu Leu Arg Ala Lys Gly Ile Thr Asp Asp 
            340                 345                 350 


<210>  3296
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTX4__Homo_sapiens__NP_001287656

<400>  3296

Met Glu Val Gly Ile Thr Ile Gln His Ala Tyr Glu Lys Gln His Pro 
1               5                   10                  15      


Trp Ile Asp Leu Thr Ser Ile Gly Phe Ser Tyr Val Ile Asp Phe Asn 
            20                  25                  30          


Thr Met Gly Gln Ile Asn Arg Gln Thr Gln Arg Gln Arg Arg Val Arg 
        35                  40                  45              


Arg Arg Leu Asp Leu Ile Tyr Pro Met Val Thr Gly Thr Leu Pro Lys 
    50                  55                  60                  


Ala Gln Ser Trp Pro Val Ser Pro Gly Pro Ala Thr Ser Pro Pro Met 
65                  70                  75                  80  


Ser Pro Cys Ser Cys Pro Gln Cys Val Leu Val Met Ser Val Lys Ala 
                85                  90                  95      


Ala Val Val Asn Gly Ser Thr Gly Pro Leu Gln Leu Pro Val Thr Arg 
            100                 105                 110         


Lys Asn Met Pro Pro Pro Gly Val Val Lys Leu Pro Pro Leu Pro Gly 
        115                 120                 125             


Ser Gly Ala Lys Pro Leu Asp Ser Thr Gly Thr Ile Arg Gly Pro Leu 
    130                 135                 140                 


Lys Thr Ala Pro Ser Gln Val Ile Arg Arg Gln Ala Ser Ser Met Pro 
145                 150                 155                 160 


Thr Gly Thr Thr Met Gly Ser Pro Ala Ser Pro Pro Gly Pro Asn Ser 
                165                 170                 175     


Lys Thr Gly Arg Val Ala Leu Ala Thr Leu Asn Arg Thr Asn Leu Gln 
            180                 185                 190         


Arg Leu Ala Ile Ala Gln Ser Arg Val Leu Ile Ala Ser Gly Val Pro 
        195                 200                 205             


Thr Val Pro Val Lys Asn Leu Asn Gly Ser Ser Pro Val Asn Pro Ala 
    210                 215                 220                 


Leu Ala Gly Ile Thr Gly Ile Leu Met Ser Ala Ala Gly Leu Pro Val 
225                 230                 235                 240 


Cys Leu Thr Arg Pro Pro Lys Leu Val Leu His Pro Pro Pro Val Ser 
                245                 250                 255     


Lys Ser Glu Ile Lys Ser Ile Pro Gly Val Ser Asn Thr Ser Arg Lys 
            260                 265                 270         


Thr Thr Lys Lys Gln Ala Lys Lys Gly Lys Thr Pro Glu Glu Val Leu 
        275                 280                 285             


Lys Lys Tyr Leu Gln Lys Val Arg His Pro Pro Asp Glu Asp Cys Thr 
    290                 295                 300                 


Ile Cys Met Glu Arg Leu Thr Ala Pro Ser Gly Tyr Lys Gly Pro Gln 
305                 310                 315                 320 


Pro Thr Val Lys Pro Asp Leu Val Gly Lys Leu Ser Arg Cys Gly His 
                325                 330                 335     


Val Tyr His Ile Tyr Cys Leu Val Ala Met Tyr Asn Asn Gly Asn Lys 
            340                 345                 350         


Asp Gly Ser Leu Gln Cys Pro Thr Cys Lys Thr Ile Tyr Gly Val Lys 
        355                 360                 365             


Thr Gly Thr Gln Pro Pro Gly Lys Met Glu Tyr His Leu Ile Pro His 
    370                 375                 380                 


Ser Leu Pro Gly His Pro Asp Cys Lys Thr Ile Arg Ile Ile Tyr Ser 
385                 390                 395                 400 


Ile Pro Pro Gly Ile Gln Gly Pro Glu His Pro Asn Pro Gly Lys Ser 
                405                 410                 415     


Phe Ser Ala Arg Gly Phe Pro Arg His Cys Tyr Leu Pro Asp Ser Glu 
            420                 425                 430         


Lys Gly Arg Lys Val Leu Lys Leu Leu Leu Val Ala Trp Asp Arg Arg 
        435                 440                 445             


Leu Ile Phe Ala Ile Gly Thr Ser Ser Thr Thr Gly Glu Ser Asp Thr 
    450                 455                 460                 


Val Ile Trp Asn Glu Val His His Lys Thr Glu Phe Gly Ser Asn Leu 
465                 470                 475                 480 


Thr Gly His Gly Tyr Pro Asp Ala Asn Tyr Leu Asp Asn Val Leu Ala 
                485                 490                 495     


Glu Leu Ala Ala Gln Gly Ile Ser Glu Asp Ser Thr Ala Gln Glu Lys 
            500                 505                 510         


Asp 
    


<210>  3297
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DTYMK__Homo_sapiens__NP_036277

<400>  3297

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  3298
<211>  1551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUOX1__Homo_sapiens__NP_787954

<400>  3298

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Gly Glu Pro His Leu Pro Asn Pro Arg Asp Leu Ser Asn 
65                  70                  75                  80  


Thr Ile Ser Arg Gly Pro Ala Gly Leu Ala Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Arg Ile Pro 
        115                 120                 125             


Pro Gly Asp Pro Met Phe Asp Pro Asp Gln Arg Gly Asp Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu Thr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Pro Ala Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Ala Leu Arg Ser Phe 
            180                 185                 190         


Ser Arg Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Arg Asp 
        195                 200                 205             


Ser Gln Asn Pro Leu Leu Met Trp Ala Ala Pro Asp Pro Ala Thr Gly 
    210                 215                 220                 


Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe Gly Ala Glu Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln His Pro Asp Trp Glu Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser Phe Leu Gln Lys Thr Leu 
    290                 295                 300                 


Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Ser 
305                 310                 315                 320 


Glu Phe Val Ala Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Pro 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Val Ile Asn 
            340                 345                 350         


Arg Asn Ser Ser Val Ser Arg Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Ser Leu Gln Ser Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Leu 
385                 390                 395                 400 


Val Glu Asp Val Arg Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg 
                405                 410                 415     


Thr Asp His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu 
            420                 425                 430         


Pro Ser Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr 
        435                 440                 445             


Arg Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val 
    450                 455                 460                 


Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu 
465                 470                 475                 480 


Leu Leu Pro Gly Gly Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu 
                485                 490                 495     


Phe Ser Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp 
            500                 505                 510         


Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu 
        515                 520                 525             


Ile Glu Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val 
    530                 535                 540                 


Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His 
545                 550                 555                 560 


Lys Gly Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu 
                565                 570                 575     


Pro Ala Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly 
            580                 585                 590         


Phe Gly Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val 
        595                 600                 605             


Ser Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe 
    610                 615                 620                 


Lys Arg Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu 
625                 630                 635                 640 


Val Gly Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys 
                645                 650                 655     


Arg Pro Val Leu Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp 
            660                 665                 670         


Gly Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys 
        675                 680                 685             


Val Asn Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu 
    690                 695                 700                 


Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu 
705                 710                 715                 720 


Glu Arg Gln Ala Leu Val Glu Asn Leu Arg Gly Ala Leu Lys Glu Ser 
                725                 730                 735     


Gly Leu Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg 
            740                 745                 750         


Ala Ala Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe 
        755                 760                 765             


Arg His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly 
    770                 775                 780                 


Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys 
785                 790                 795                 800 


Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln 
                805                 810                 815     


Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn 
            820                 825                 830         


Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met 
        835                 840                 845             


Lys Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp 
    850                 855                 860                 


Phe Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu 
865                 870                 875                 880 


Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu 
                885                 890                 895     


Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys 
            900                 905                 910         


Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn 
        915                 920                 925             


Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro 
    930                 935                 940                 


Glu Val Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp 
945                 950                 955                 960 


Met Ile Cys Pro Ser Pro Arg Val Ser Ala Arg Cys Ser Arg Ser Asp 
                965                 970                 975     


Ile Glu Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr 
            980                 985                 990         


Asp Pro Pro Gln Glu Ile Arg Arg  Arg Phe Gly Lys Lys  Val Thr Ser 
        995                 1000                 1005             


Phe Gln  Pro Leu Leu Phe Thr  Glu Ala His Arg Glu  Lys Phe Gln 
    1010                 1015                 1020             


Arg Ser  Cys Leu His Gln Thr  Val Gln Gln Phe Lys  Arg Phe Ile 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Arg His Ile  Gly Cys Val Ala Val  Phe Tyr Ala 
    1040                 1045                 1050             


Ile Ala  Gly Gly Leu Phe Leu  Glu Arg Ala Tyr Tyr  Tyr Ala Phe 
    1055                 1060                 1065             


Ala Ala  His His Thr Gly Ile  Thr Asp Thr Thr Arg  Val Gly Ile 
    1070                 1075                 1080             


Ile Leu  Ser Arg Gly Thr Ala  Ala Ser Ile Ser Phe  Met Phe Ser 
    1085                 1090                 1095             


Tyr Ile  Leu Leu Thr Met Cys  Arg Asn Leu Ile Thr  Phe Leu Arg 
    1100                 1105                 1110             


Glu Thr  Phe Leu Asn Arg Tyr  Val Pro Phe Asp Ala  Ala Val Asp 
    1115                 1120                 1125             


Phe His  Arg Leu Ile Ala Ser  Thr Ala Ile Val Leu  Thr Val Leu 
    1130                 1135                 1140             


His Ser  Val Gly His Val Val  Asn Val Tyr Leu Phe  Ser Ile Ser 
    1145                 1150                 1155             


Pro Leu  Ser Val Leu Ser Cys  Leu Phe Pro Gly Leu  Phe His Asp 
    1160                 1165                 1170             


Asp Gly  Ser Glu Leu Pro Gln  Lys Tyr Tyr Trp Trp  Phe Phe Gln 
    1175                 1180                 1185             


Thr Val  Pro Gly Leu Thr Gly  Val Val Leu Leu Leu  Ile Leu Ala 
    1190                 1195                 1200             


Ile Met  Tyr Val Phe Ala Ser  His His Phe Arg Arg  Arg Ser Phe 
    1205                 1210                 1215             


Arg Gly  Phe Trp Leu Thr His  His Leu Tyr Ile Leu  Leu Tyr Val 
    1220                 1225                 1230             


Leu Leu  Ile Ile His Gly Ser  Phe Ala Leu Ile Gln  Leu Pro Arg 
    1235                 1240                 1245             


Phe His  Ile Phe Phe Leu Val  Pro Ala Ile Ile Tyr  Gly Gly Asp 
    1250                 1255                 1260             


Lys Leu  Val Ser Leu Ser Arg  Lys Lys Val Glu Ile  Ser Val Val 
    1265                 1270                 1275             


Lys Ala  Glu Leu Leu Pro Ser  Gly Val Thr His Leu  Arg Phe Gln 
    1280                 1285                 1290             


Arg Pro  Gln Gly Phe Glu Tyr  Lys Ser Gly Gln Trp  Val Arg Ile 
    1295                 1300                 1305             


Ala Cys  Leu Ala Leu Gly Thr  Thr Glu Tyr His Pro  Phe Thr Leu 
    1310                 1315                 1320             


Thr Ser  Ala Pro His Glu Asp  Thr Leu Ser Leu His  Ile Arg Ala 
    1325                 1330                 1335             


Ala Gly  Pro Trp Thr Thr Arg  Leu Arg Glu Ile Tyr  Ser Ala Pro 
    1340                 1345                 1350             


Thr Gly  Asp Arg Cys Ala Arg  Tyr Pro Lys Leu Tyr  Leu Asp Gly 
    1355                 1360                 1365             


Pro Phe  Gly Glu Gly His Gln  Glu Trp His Lys Phe  Glu Val Ser 
    1370                 1375                 1380             


Val Leu  Val Gly Gly Gly Ile  Gly Val Thr Pro Phe  Ala Ser Ile 
    1385                 1390                 1395             


Leu Lys  Asp Leu Val Phe Lys  Ser Ser Val Ser Cys  Gln Val Phe 
    1400                 1405                 1410             


Cys Lys  Lys Ile Tyr Phe Ile  Trp Val Thr Arg Thr  Gln Arg Gln 
    1415                 1420                 1425             


Phe Glu  Trp Leu Ala Asp Ile  Ile Arg Glu Val Glu  Glu Asn Asp 
    1430                 1435                 1440             


His Gln  Asp Leu Val Ser Val  His Ile Tyr Ile Thr  Gln Leu Ala 
    1445                 1450                 1455             


Glu Lys  Phe Asp Leu Arg Thr  Thr Met Leu Tyr Ile  Cys Glu Arg 
    1460                 1465                 1470             


His Phe  Gln Lys Val Leu Asn  Arg Ser Leu Phe Thr  Gly Leu Arg 
    1475                 1480                 1485             


Ser Ile  Thr His Phe Gly Arg  Pro Pro Phe Glu Pro  Phe Phe Asn 
    1490                 1495                 1500             


Ser Leu  Gln Glu Val His Pro  Gln Val Arg Lys Ile  Gly Val Phe 
    1505                 1510                 1515             


Ser Cys  Gly Pro Pro Gly Met  Thr Lys Asn Val Glu  Lys Ala Cys 
    1520                 1525                 1530             


Gln Leu  Ile Asn Arg Gln Asp  Arg Thr His Phe Ser  His His Tyr 
    1535                 1540                 1545             


Glu Asn  Phe 
    1550     


<210>  3299
<211>  1548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUOX2__Homo_sapiens__NP_054799

<400>  3299

Met Leu Arg Ala Arg Pro Glu Ala Leu Met Leu Leu Gly Ala Leu Leu 
1               5                   10                  15      


Thr Gly Ser Leu Gly Pro Ser Gly Asn Gln Asp Ala Leu Ser Leu Pro 
            20                  25                  30          


Trp Glu Val Gln Arg Tyr Asp Gly Trp Phe Asn Asn Leu Arg His His 
        35                  40                  45              


Glu Arg Gly Ala Val Gly Cys Arg Leu Gln Arg Arg Val Pro Ala Asn 
    50                  55                  60                  


Tyr Ala Asp Gly Val Tyr Gln Ala Leu Glu Glu Pro Gln Leu Pro Asn 
65                  70                  75                  80  


Pro Arg Arg Leu Ser Asn Ala Ala Thr Arg Gly Ile Ala Gly Leu Pro 
                85                  90                  95      


Ser Leu His Asn Arg Thr Val Leu Gly Val Phe Phe Gly Tyr His Val 
            100                 105                 110         


Leu Ser Asp Val Val Ser Val Glu Thr Pro Gly Cys Pro Ala Glu Phe 
        115                 120                 125             


Leu Asn Ile Arg Ile Pro Pro Gly Asp Pro Val Phe Asp Pro Asp Gln 
    130                 135                 140                 


Arg Gly Asp Val Val Leu Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu 
145                 150                 155                 160 


Thr Gly Arg Ser Pro Ser Asn Pro Arg Asp Leu Ala Asn Gln Val Thr 
                165                 170                 175     


Gly Trp Leu Asp Gly Ser Ala Ile Tyr Gly Ser Ser His Ser Trp Ser 
            180                 185                 190         


Asp Ala Leu Arg Ser Phe Ser Gly Gly Gln Leu Ala Ser Gly Pro Asp 
        195                 200                 205             


Pro Ala Phe Pro Arg Asp Ser Gln Asn Pro Leu Leu Met Trp Ala Ala 
    210                 215                 220                 


Pro Asp Pro Ala Thr Gly Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe 
225                 230                 235                 240 


Gly Ala Glu Arg Gly Asn Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu 
                245                 250                 255     


Leu Trp Phe Arg Tyr His Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln 
            260                 265                 270         


His Pro Asp Trp Glu Asp Glu Glu Leu Phe Gln His Ala Arg Lys Arg 
        275                 280                 285             


Val Ile Ala Thr Tyr Gln Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser 
    290                 295                 300                 


Phe Leu Gln Lys Thr Leu Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu 
305                 310                 315                 320 


Asp Pro Ser Ile Ser Pro Glu Phe Val Val Ala Ser Glu Gln Phe Phe 
                325                 330                 335     


Ser Thr Met Val Pro Pro Gly Val Tyr Met Arg Asn Ala Ser Cys His 
            340                 345                 350         


Phe Arg Lys Val Leu Asn Lys Gly Phe Gln Ser Ser Gln Ala Leu Arg 
        355                 360                 365             


Val Cys Asn Asn Tyr Trp Ile Arg Glu Asn Pro Asn Leu Asn Ser Thr 
    370                 375                 380                 


Gln Glu Val Asn Glu Leu Leu Leu Gly Met Ala Ser Gln Ile Ser Glu 
385                 390                 395                 400 


Leu Glu Asp Asn Ile Val Val Glu Asp Leu Arg Asp Tyr Trp Pro Gly 
                405                 410                 415     


Pro Gly Lys Phe Ser Arg Thr Asp Tyr Val Ala Ser Ser Ile Gln Arg 
            420                 425                 430         


Gly Arg Asp Met Gly Leu Pro Ser Tyr Ser Gln Ala Leu Leu Ala Phe 
        435                 440                 445             


Gly Leu Asp Ile Pro Arg Asn Trp Ser Asp Leu Asn Pro Asn Val Asp 
    450                 455                 460                 


Pro Gln Val Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser 
465                 470                 475                 480 


Gln Leu Glu Leu Leu Leu Gly Gly Leu Leu Glu Ser His Gly Asp Pro 
                485                 490                 495     


Gly Pro Leu Phe Ser Ala Ile Val Leu Asp Gln Phe Val Arg Leu Arg 
            500                 505                 510         


Asp Gly Asp Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser 
        515                 520                 525             


Lys Lys Glu Ile Glu Asp Ile Arg Asn Thr Thr Leu Arg Asp Val Leu 
    530                 535                 540                 


Val Ala Val Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe 
545                 550                 555                 560 


Val Trp His Lys Gly Ala Pro Cys Pro Gln Pro Lys Gln Leu Thr Thr 
                565                 570                 575     


Asp Gly Leu Pro Gln Cys Ala Pro Leu Thr Val Leu Asp Phe Phe Glu 
            580                 585                 590         


Gly Ser Ser Pro Gly Phe Ala Ile Thr Ile Ile Ala Leu Cys Cys Leu 
        595                 600                 605             


Pro Leu Val Ser Leu Leu Leu Ser Gly Val Val Ala Tyr Phe Arg Gly 
    610                 615                 620                 


Arg Glu His Lys Lys Leu Gln Lys Lys Leu Lys Glu Ser Val Lys Lys 
625                 630                 635                 640 


Glu Ala Ala Lys Asp Gly Val Pro Ala Met Glu Trp Pro Gly Pro Lys 
                645                 650                 655     


Glu Arg Ser Ser Pro Ile Ile Ile Gln Leu Leu Ser Asp Arg Cys Leu 
            660                 665                 670         


Gln Val Leu Asn Arg His Leu Thr Val Leu Arg Val Val Gln Leu Gln 
        675                 680                 685             


Pro Leu Gln Gln Val Asn Leu Ile Leu Ser Asn Asn Arg Gly Cys Arg 
    690                 695                 700                 


Thr Leu Leu Leu Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe 
705                 710                 715                 720 


Ser Ser Glu Glu Glu Arg Gly Ala Phe Val Gln Gln Leu Trp Asp Phe 
                725                 730                 735     


Cys Val Arg Trp Ala Leu Gly Leu His Val Ala Glu Met Ser Glu Lys 
            740                 745                 750         


Glu Leu Phe Arg Lys Ala Val Thr Lys Gln Gln Arg Glu Arg Ile Leu 
        755                 760                 765             


Glu Ile Phe Phe Arg His Leu Phe Ala Gln Val Leu Asp Ile Asn Gln 
    770                 775                 780                 


Ala Asp Ala Gly Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu 
785                 790                 795                 800 


Ala Leu Thr Cys Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly 
                805                 810                 815     


Leu Lys Pro Gln Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp 
            820                 825                 830         


Lys Asp Gly Asn Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu 
        835                 840                 845             


Val Val Phe Met Lys Gly Ser Pro Glu Asp Lys Ser Arg Leu Met Phe 
    850                 855                 860                 


Thr Met Tyr Asp Leu Asp Glu Asn Gly Phe Leu Ser Lys Asp Glu Phe 
865                 870                 875                 880 


Phe Thr Met Met Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser 
                885                 890                 895     


Lys Ala Gln Leu Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly 
            900                 905                 910         


Phe Gln Asp Lys Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu 
        915                 920                 925             


Arg Asp His Asp Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly 
    930                 935                 940                 


Gly Gly Gly Gly Gly Asn Gly Ile Arg Asp Ile Phe Lys Gln Asn Ile 
945                 950                 955                 960 


Ser Cys Arg Val Ser Phe Ile Thr Arg Thr Pro Gly Glu Arg Ser His 
                965                 970                 975     


Pro Gln Gly Leu Gly Pro Pro Ala Pro Glu Ala Pro Glu Leu Gly Gly 
            980                 985                 990         


Pro Gly Leu Lys Lys Arg Phe Gly  Lys Lys Ala Ala Val  Pro Thr Pro 
        995                 1000                 1005             


Arg Leu  Tyr Thr Glu Ala Leu  Gln Glu Lys Met Gln  Arg Gly Phe 
    1010                 1015                 1020             


Leu Ala  Gln Lys Leu Gln Gln  Tyr Lys Arg Phe Val  Glu Asn Tyr 
    1025                 1030                 1035             


Arg Arg  His Ile Val Cys Val  Ala Ile Phe Ser Ala  Ile Cys Val 
    1040                 1045                 1050             


Gly Val  Phe Ala Asp Arg Ala  Tyr Tyr Tyr Gly Phe  Ala Ser Pro 
    1055                 1060                 1065             


Pro Ser  Asp Ile Ala Gln Thr  Thr Leu Val Gly Ile  Ile Leu Ser 
    1070                 1075                 1080             


Arg Gly  Thr Ala Ala Ser Val  Ser Phe Met Phe Ser  Tyr Ile Leu 
    1085                 1090                 1095             


Leu Thr  Met Cys Arg Asn Leu  Ile Thr Phe Leu Arg  Glu Thr Phe 
    1100                 1105                 1110             


Leu Asn  Arg Tyr Val Pro Phe  Asp Ala Ala Val Asp  Phe His Arg 
    1115                 1120                 1125             


Trp Ile  Ala Met Ala Ala Val  Val Leu Ala Ile Leu  His Ser Ala 
    1130                 1135                 1140             


Gly His  Ala Val Asn Val Tyr  Ile Phe Ser Val Ser  Pro Leu Ser 
    1145                 1150                 1155             


Leu Leu  Ala Cys Ile Phe Pro  Asn Val Phe Val Asn  Asp Gly Ser 
    1160                 1165                 1170             


Lys Leu  Pro Gln Lys Phe Tyr  Trp Trp Phe Phe Gln  Thr Val Pro 
    1175                 1180                 1185             


Gly Met  Thr Gly Val Leu Leu  Leu Leu Val Leu Ala  Ile Met Tyr 
    1190                 1195                 1200             


Val Phe  Ala Ser His His Phe  Arg Arg Arg Ser Phe  Arg Gly Phe 
    1205                 1210                 1215             


Trp Leu  Thr His His Leu Tyr  Ile Leu Leu Tyr Ala  Leu Leu Ile 
    1220                 1225                 1230             


Ile His  Gly Ser Tyr Ala Leu  Ile Gln Leu Pro Thr  Phe His Ile 
    1235                 1240                 1245             


Tyr Phe  Leu Val Pro Ala Ile  Ile Tyr Gly Gly Asp  Lys Leu Val 
    1250                 1255                 1260             


Ser Leu  Ser Arg Lys Lys Val  Glu Ile Ser Val Val  Lys Ala Glu 
    1265                 1270                 1275             


Leu Leu  Pro Ser Gly Val Thr  Tyr Leu Gln Phe Gln  Arg Pro Gln 
    1280                 1285                 1290             


Gly Phe  Glu Tyr Lys Ser Gly  Gln Trp Val Arg Ile  Ala Cys Leu 
    1295                 1300                 1305             


Ala Leu  Gly Thr Thr Glu Tyr  His Pro Phe Thr Leu  Thr Ser Ala 
    1310                 1315                 1320             


Pro His  Glu Asp Thr Leu Ser  Leu His Ile Arg Ala  Val Gly Pro 
    1325                 1330                 1335             


Trp Thr  Thr Arg Leu Arg Glu  Ile Tyr Ser Ser Pro  Lys Gly Asn 
    1340                 1345                 1350             


Gly Cys  Ala Gly Tyr Pro Lys  Leu Tyr Leu Asp Gly  Pro Phe Gly 
    1355                 1360                 1365             


Glu Gly  His Gln Glu Trp His  Lys Phe Glu Val Ser  Val Leu Val 
    1370                 1375                 1380             


Gly Gly  Gly Ile Gly Val Thr  Pro Phe Ala Ser Ile  Leu Lys Asp 
    1385                 1390                 1395             


Leu Val  Phe Lys Ser Ser Leu  Gly Ser Gln Met Leu  Cys Lys Lys 
    1400                 1405                 1410             


Ile Tyr  Phe Ile Trp Val Thr  Arg Thr Gln Arg Gln  Phe Glu Trp 
    1415                 1420                 1425             


Leu Ala  Asp Ile Ile Gln Glu  Val Glu Glu Asn Asp  His Gln Asp 
    1430                 1435                 1440             


Leu Val  Ser Val His Ile Tyr  Val Thr Gln Leu Ala  Glu Lys Phe 
    1445                 1450                 1455             


Asp Leu  Arg Thr Thr Met Leu  Tyr Ile Cys Glu Arg  His Phe Gln 
    1460                 1465                 1470             


Lys Val  Leu Asn Arg Ser Leu  Phe Thr Gly Leu Arg  Ser Ile Thr 
    1475                 1480                 1485             


His Phe  Gly Arg Pro Pro Phe  Glu Pro Phe Phe Asn  Ser Leu Gln 
    1490                 1495                 1500             


Glu Val  His Pro Gln Val Arg  Lys Ile Gly Val Phe  Ser Cys Gly 
    1505                 1510                 1515             


Pro Pro  Gly Met Thr Lys Asn  Val Glu Lys Ala Cys  Gln Leu Val 
    1520                 1525                 1530             


Asn Arg  Gln Asp Arg Ala His  Phe Met His His Tyr  Glu Asn Phe 
    1535                 1540                 1545             


<210>  3300
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUOXA1__Homo_sapiens__NP_001263193

<400>  3300

Met Ala Thr Leu Gly His Thr Phe Pro Phe Tyr Ala Gly Pro Lys Pro 
1               5                   10                  15      


Thr Phe Pro Met Asp Thr Thr Leu Ala Ser Ile Ile Met Ile Phe Leu 
            20                  25                  30          


Thr Ala Leu Ala Thr Phe Ile Val Ile Leu Pro Gly Ile Arg Gly Lys 
        35                  40                  45              


Thr Arg Leu Phe Trp Leu Leu Arg Val Val Thr Ser Leu Phe Ile Gly 
    50                  55                  60                  


Ala Ala Ile Leu Ala Val Asn Phe Ser Ser Glu Trp Ser Val Gly Gln 
65                  70                  75                  80  


Val Ser Thr Asn Thr Ser Tyr Lys Ala Phe Ser Ser Glu Trp Ile Ser 
                85                  90                  95      


Ala Asp Ile Gly Leu Gln Val Gly Leu Gly Gly Val Asn Ile Thr Leu 
            100                 105                 110         


Thr Gly Thr Pro Val Gln Gln Leu Asn Glu Thr Ile Asn Tyr Asn Glu 
        115                 120                 125             


Glu Phe Thr Trp Arg Leu Gly Glu Asn Tyr Ala Glu Glu Tyr Ala Lys 
    130                 135                 140                 


Ala Leu Glu Lys Gly Leu Pro Asp Pro Val Leu Tyr Leu Ala Glu Lys 
145                 150                 155                 160 


Phe Thr Pro Arg Ser Pro Cys Gly Leu Tyr Arg Gln Tyr Arg Leu Ala 
                165                 170                 175     


Gly His Tyr Thr Ser Ala Met Leu Trp Val Ala Phe Leu Cys Trp Leu 
            180                 185                 190         


Leu Ala Asn Val Met Leu Ser Met Pro Val Leu Val Tyr Gly Gly Tyr 
        195                 200                 205             


Met Leu Leu Ala Thr Gly Ile Phe Gln Leu Leu Ala Leu Leu Phe Phe 
    210                 215                 220                 


Ser Met Ala Thr Ser Leu Thr Ser Pro Cys Pro Leu His Leu Gly Ala 
225                 230                 235                 240 


Ser Val Leu His Thr His His Gly Pro Ala Phe Trp Ile Thr Leu Thr 
                245                 250                 255     


Thr Gly Leu Leu Cys Val Leu Leu Gly Leu Ala Met Ala Val Ala His 
            260                 265                 270         


Arg Met Gln Pro His Arg Leu Lys Ala Phe Phe Asn Gln Ser Val Asp 
        275                 280                 285             


Glu Asp Pro Met Leu Glu Trp Ser Pro Glu Glu Gly Gly Leu Leu Ser 
    290                 295                 300                 


Pro Arg Tyr Arg Ser Met Ala Asp Ser Pro Lys Ser Gln Asp Ile Pro 
305                 310                 315                 320 


Leu Ser Glu Ala Ser Ser Thr Lys Ala Tyr Tyr Arg Pro Arg Arg Leu 
                325                 330                 335     


Ser Leu Val Pro Ala Asp Val Arg Gly Leu Ala Pro Ala Ala Leu Ser 
            340                 345                 350         


Ala Leu Pro Gly Ala Leu Leu Ala Gln Ala Trp Arg Ala Leu Leu Pro 
        355                 360                 365             


Gly Leu Arg Cys Pro Lys Ala Gly Lys Glu Ser Arg Leu Gly Pro Pro 
    370                 375                 380                 


His Ser Pro Trp Arg Phe Gly Pro Glu Gly Cys Glu Glu Arg Trp Ala 
385                 390                 395                 400 


Glu His Thr Gly Asp Ser Pro Arg Pro Leu Arg Gly Arg Gly Thr Gly 
                405                 410                 415     


Arg Leu Trp Arg Trp Gly Ser Lys Glu Arg Arg Ala Cys Gly Val Arg 
            420                 425                 430         


Ala Met Leu Pro Arg Leu Val Ser Asn Ser Gly Leu Lys Arg Pro Ser 
        435                 440                 445             


Cys Leu Asp Leu Pro Lys Cys Trp Asp Tyr Arg Arg Asp Ala Arg Ala 
    450                 455                 460                 


Phe Phe His Leu Leu Glu Pro Thr Pro Cys Val Thr Ser Arg His Thr 
465                 470                 475                 480 


Pro Leu Ile 
            


<210>  3301
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUOXA2__Homo_sapiens__NP_997464

<400>  3301

Met Thr Leu Trp Asn Gly Val Leu Pro Phe Tyr Pro Gln Pro Arg His 
1               5                   10                  15      


Ala Ala Gly Phe Ser Val Pro Leu Leu Ile Val Ile Leu Val Phe Leu 
            20                  25                  30          


Ala Leu Ala Ala Ser Phe Leu Leu Ile Leu Pro Gly Ile Arg Gly His 
        35                  40                  45              


Ser Arg Trp Phe Trp Leu Val Arg Val Leu Leu Ser Leu Phe Ile Gly 
    50                  55                  60                  


Ala Glu Ile Val Ala Val His Phe Ser Ala Glu Trp Phe Val Gly Thr 
65                  70                  75                  80  


Val Asn Thr Asn Thr Ser Tyr Lys Ala Phe Ser Ala Ala Arg Val Thr 
                85                  90                  95      


Ala Arg Val Arg Leu Leu Val Gly Leu Glu Gly Ile Asn Ile Thr Leu 
            100                 105                 110         


Thr Gly Thr Pro Val His Gln Leu Asn Glu Thr Ile Asp Tyr Asn Glu 
        115                 120                 125             


Gln Phe Thr Trp Arg Leu Lys Glu Asn Tyr Ala Ala Glu Tyr Ala Asn 
    130                 135                 140                 


Ala Leu Glu Lys Gly Leu Pro Asp Pro Val Leu Tyr Leu Ala Glu Lys 
145                 150                 155                 160 


Phe Thr Pro Ser Ser Pro Cys Gly Leu Tyr His Gln Tyr His Leu Ala 
                165                 170                 175     


Gly His Tyr Ala Ser Ala Thr Leu Trp Val Ala Phe Cys Phe Trp Leu 
            180                 185                 190         


Leu Ser Asn Val Leu Leu Ser Thr Pro Ala Pro Leu Tyr Gly Gly Leu 
        195                 200                 205             


Ala Leu Leu Thr Thr Gly Ala Phe Ala Leu Phe Gly Val Phe Ala Leu 
    210                 215                 220                 


Ala Ser Ile Ser Ser Val Pro Leu Cys Pro Leu Arg Leu Gly Ser Ser 
225                 230                 235                 240 


Ala Leu Thr Thr Gln Tyr Gly Ala Ala Phe Trp Val Thr Leu Ala Thr 
                245                 250                 255     


Gly Val Leu Cys Leu Phe Leu Gly Gly Ala Val Val Ser Leu Gln Tyr 
            260                 265                 270         


Val Arg Pro Ser Ala Leu Arg Thr Leu Leu Asp Gln Ser Ala Lys Asp 
        275                 280                 285             


Cys Ser Gln Glu Arg Gly Gly Ser Pro Leu Ile Leu Gly Asp Pro Leu 
    290                 295                 300                 


His Lys Gln Ala Ala Leu Pro Asp Leu Lys Cys Ile Thr Thr Asn Leu 
305                 310                 315                 320 


<210>  3302
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUPD1__Homo_sapiens__NP_001003892

<400>  3302

Met Thr Ser Gly Glu Val Lys Thr Ser Leu Lys Asn Ala Tyr Ser Ser 
1               5                   10                  15      


Ala Lys Arg Leu Ser Pro Lys Met Glu Glu Glu Gly Glu Glu Glu Asp 
            20                  25                  30          


Tyr Cys Thr Pro Gly Ala Phe Glu Leu Glu Arg Leu Phe Trp Lys Gly 
        35                  40                  45              


Ser Pro Gln Tyr Thr His Val Asn Glu Val Trp Pro Lys Leu Tyr Ile 
    50                  55                  60                  


Gly Asp Glu Ala Thr Ala Leu Asp Arg Tyr Arg Leu Gln Lys Ala Gly 
65                  70                  75                  80  


Phe Thr His Val Leu Asn Ala Ala His Gly Arg Trp Asn Val Asp Thr 
                85                  90                  95      


Gly Pro Asp Tyr Tyr Arg Asp Met Asp Ile Gln Tyr His Gly Val Glu 
            100                 105                 110         


Ala Asp Asp Leu Pro Thr Phe Asp Leu Ser Val Phe Phe Tyr Pro Ala 
        115                 120                 125             


Ala Ala Phe Ile Asp Arg Ala Leu Ser Asp Asp His Ser Lys Ile Leu 
    130                 135                 140                 


Val His Cys Val Met Gly Arg Ser Arg Ser Ala Thr Leu Val Leu Ala 
145                 150                 155                 160 


Tyr Leu Met Ile His Lys Asp Met Thr Leu Val Asp Ala Ile Gln Gln 
                165                 170                 175     


Val Ala Lys Asn Arg Cys Val Leu Pro Asn Arg Gly Phe Leu Lys Gln 
            180                 185                 190         


Leu Arg Glu Leu Asp Lys Gln Leu Val Gln Gln Arg Arg Arg Ser Gln 
        195                 200                 205             


Arg Gln Asp Gly Glu Glu Glu Asp Gly Arg Glu Leu 
    210                 215                 220 


<210>  3303
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUS2__Homo_sapiens__NP_001258691

<400>  3303

Met Ile Leu Asn Ser Leu Ser Leu Cys Tyr His Asn Lys Leu Ile Leu 
1               5                   10                  15      


Ala Pro Met Val Arg Val Gly Thr Leu Pro Met Arg Leu Leu Ala Leu 
            20                  25                  30          


Asp Tyr Gly Ala Asp Ile Val Tyr Cys Glu Glu Leu Ile Asp Leu Lys 
        35                  40                  45              


Met Ile Gln Cys Lys Arg Val Val Asn Glu Val Leu Ser Thr Val Asp 
    50                  55                  60                  


Phe Val Ala Pro Asp Asp Arg Val Val Phe Arg Thr Cys Glu Arg Glu 
65                  70                  75                  80  


Gln Asn Arg Val Val Phe Gln Met Gly Thr Ser Asp Ala Glu Arg Ala 
                85                  90                  95      


Leu Ala Val Ala Arg Leu Val Glu Asn Asp Val Ala Gly Ile Asp Val 
            100                 105                 110         


Asn Met Gly Cys Pro Lys Gln Tyr Ser Thr Lys Gly Gly Met Gly Ala 
        115                 120                 125             


Ala Leu Leu Ser Asp Pro Asp Lys Ile Glu Lys Ile Leu Ser Thr Leu 
    130                 135                 140                 


Val Lys Gly Thr Arg Arg Pro Val Thr Cys Lys Ile Arg Ile Leu Pro 
145                 150                 155                 160 


Ser Leu Glu Asp Thr Leu Ser Leu Val Lys Arg Ile Glu Arg Thr Gly 
                165                 170                 175     


Ile Ala Ala Ile Ala Val His Gly Arg Lys Arg Glu Glu Arg Pro Gln 
            180                 185                 190         


His Pro Val Ser Cys Glu Val Ile Lys Ala Ile Ala Asp Thr Leu Ser 
        195                 200                 205             


Ile Pro Val Ile Ala Asn Gly Gly Ser His Asp His Ile Gln Gln Tyr 
    210                 215                 220                 


Ser Asp Ile Glu Asp Phe Arg Gln Ala Thr Ala Ala Ser Ser Val Met 
225                 230                 235                 240 


Val Ala Arg Ala Ala Met Trp Asn Pro Ser Ile Phe Leu Lys Glu Gly 
                245                 250                 255     


Leu Arg Pro Leu Glu Glu Val Met Gln Lys Tyr Ile Arg Tyr Ala Val 
            260                 265                 270         


Gln Tyr Asp Asn His Tyr Thr Asn Thr Lys Tyr Cys Leu Cys Gln Met 
        275                 280                 285             


Leu Arg Glu Gln Leu Glu Ser Pro Gln Gly Arg Leu Leu His Ala Ala 
    290                 295                 300                 


Gln Ser Ser Arg Glu Ile Cys Glu Ala Phe Gly Leu Gly Ala Phe Tyr 
305                 310                 315                 320 


Glu Glu Thr Thr Gln Glu Leu Asp Ala Gln Gln Ala Arg Leu Ser Ala 
                325                 330                 335     


Lys Thr Ser Glu Gln Thr Gly Glu Pro Ala Glu Asp Thr Ser Gly Val 
            340                 345                 350         


Ile Lys Met Ala Val Lys Phe Asp Arg Arg Ala Tyr Pro Ala Gln Ile 
        355                 360                 365             


Thr Pro Lys Met Cys Leu Leu Glu Trp Cys Arg Arg Glu Lys Leu Ala 
    370                 375                 380                 


Gln Pro Val Tyr Glu Thr Val Gln Arg Pro Leu Asp Arg Leu Phe Ser 
385                 390                 395                 400 


Ser Ile Val Thr Val Ala Glu Gln Lys Tyr Gln Ser Thr Leu Trp Asp 
                405                 410                 415     


Lys Ser Lys Lys Leu Ala Glu Gln Ala Ala Ala Ile Val Cys Leu Arg 
            420                 425                 430         


Ser Gln Gly Leu Pro Glu Gly Arg Leu Gly Glu Glu Ser Pro Ser Leu 
        435                 440                 445             


His Lys Arg Lys Arg Glu Ala Pro Asp Gln Asp Pro Gly Gly Pro Arg 
    450                 455                 460                 


Ala Gln Glu Leu Ala Gln Pro Gly Asp Leu Cys Lys Lys Pro Phe Val 
465                 470                 475                 480 


Ala Leu Gly Ser Gly Glu Glu Ser Pro Leu Glu Gly Trp 
                485                 490             


<210>  3304
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP10__Homo_sapiens__NP_009138

<400>  3304

Met Pro Pro Ser Pro Leu Asp Asp Arg Val Val Val Ala Leu Ser Arg 
1               5                   10                  15      


Pro Val Arg Pro Gln Asp Leu Asn Leu Cys Leu Asp Ser Ser Tyr Leu 
            20                  25                  30          


Gly Ser Ala Asn Pro Gly Ser Asn Ser His Pro Pro Val Ile Ala Thr 
        35                  40                  45              


Thr Val Val Ser Leu Lys Ala Ala Asn Leu Thr Tyr Met Pro Ser Ser 
    50                  55                  60                  


Ser Gly Ser Ala Arg Ser Leu Asn Cys Gly Cys Ser Ser Ala Ser Cys 
65                  70                  75                  80  


Cys Thr Val Ala Thr Tyr Asp Lys Asp Asn Gln Ala Gln Thr Gln Ala 
                85                  90                  95      


Ile Ala Ala Gly Thr Thr Thr Thr Ala Ile Gly Thr Ser Thr Thr Cys 
            100                 105                 110         


Pro Ala Asn Gln Met Val Asn Asn Asn Glu Asn Thr Gly Ser Leu Ser 
        115                 120                 125             


Pro Ser Ser Gly Val Gly Ser Pro Val Ser Gly Thr Pro Lys Gln Leu 
    130                 135                 140                 


Ala Ser Ile Lys Ile Ile Tyr Pro Asn Asp Leu Ala Lys Lys Met Thr 
145                 150                 155                 160 


Lys Cys Ser Lys Ser His Leu Pro Ser Gln Gly Pro Val Ile Ile Asp 
                165                 170                 175     


Cys Arg Pro Phe Met Glu Tyr Asn Lys Ser His Ile Gln Gly Ala Val 
            180                 185                 190         


His Ile Asn Cys Ala Asp Lys Ile Ser Arg Arg Arg Leu Gln Gln Gly 
        195                 200                 205             


Lys Ile Thr Val Leu Asp Leu Ile Ser Cys Arg Glu Gly Lys Asp Ser 
    210                 215                 220                 


Phe Lys Arg Ile Phe Ser Lys Glu Ile Ile Val Tyr Asp Glu Asn Thr 
225                 230                 235                 240 


Asn Glu Pro Ser Arg Val Met Pro Ser Gln Pro Leu His Ile Val Leu 
                245                 250                 255     


Glu Ser Leu Lys Arg Glu Gly Lys Glu Pro Leu Val Leu Lys Gly Gly 
            260                 265                 270         


Leu Ser Ser Phe Lys Gln Asn His Glu Asn Leu Cys Asp Asn Ser Leu 
        275                 280                 285             


Gln Leu Gln Glu Cys Arg Glu Val Gly Gly Gly Ala Ser Ala Ala Ser 
    290                 295                 300                 


Ser Leu Leu Pro Gln Pro Ile Pro Thr Thr Pro Asp Ile Glu Asn Ala 
305                 310                 315                 320 


Glu Leu Thr Pro Ile Leu Pro Phe Leu Phe Leu Gly Asn Glu Gln Asp 
                325                 330                 335     


Ala Gln Asp Leu Asp Thr Met Gln Arg Leu Asn Ile Gly Tyr Val Ile 
            340                 345                 350         


Asn Val Thr Thr His Leu Pro Leu Tyr His Tyr Glu Lys Gly Leu Phe 
        355                 360                 365             


Asn Tyr Lys Arg Leu Pro Ala Thr Asp Ser Asn Lys Gln Asn Leu Arg 
    370                 375                 380                 


Gln Tyr Phe Glu Glu Ala Phe Glu Phe Ile Glu Glu Ala His Gln Cys 
385                 390                 395                 400 


Gly Lys Gly Leu Leu Ile His Cys Gln Ala Gly Val Ser Arg Ser Ala 
                405                 410                 415     


Thr Ile Val Ile Ala Tyr Leu Met Lys His Thr Arg Met Thr Met Thr 
            420                 425                 430         


Asp Ala Tyr Lys Phe Val Lys Gly Lys Arg Pro Ile Ile Ser Pro Asn 
        435                 440                 445             


Leu Asn Phe Met Gly Gln Leu Leu Glu Phe Glu Glu Asp Leu Asn Asn 
    450                 455                 460                 


Gly Val Thr Pro Arg Ile Leu Thr Pro Lys Leu Met Gly Val Glu Thr 
465                 470                 475                 480 


Val Val 
        


<210>  3305
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP11__Homo_sapiens__NP_003575

<400>  3305

Met Arg Asn Ser Glu Thr Leu Glu Arg Gly Val Gly Gly Cys Arg Val 
1               5                   10                  15      


Phe Ser Cys Leu Gly Ser Tyr Pro Gly Ile Glu Gly Ala Gly Leu Ala 
            20                  25                  30          


Leu Leu Ala Asp Leu Ala Leu Gly Gly Arg Leu Leu Gly Thr His Met 
        35                  40                  45              


Ser Gln Trp His His Pro Arg Ser Gly Trp Gly Arg Arg Arg Asp Phe 
    50                  55                  60                  


Ser Gly Arg Ser Ser Ala Lys Lys Lys Gly Gly Asn His Ile Pro Glu 
65                  70                  75                  80  


Arg Trp Lys Asp Tyr Leu Pro Val Gly Gln Arg Met Pro Gly Thr Arg 
                85                  90                  95      


Phe Ile Ala Phe Lys Val Pro Leu Gln Lys Ser Phe Glu Lys Lys Leu 
            100                 105                 110         


Ala Pro Glu Glu Cys Phe Ser Pro Leu Asp Leu Phe Asn Lys Ile Arg 
        115                 120                 125             


Glu Gln Asn Glu Glu Leu Gly Leu Ile Ile Asp Leu Thr Tyr Thr Gln 
    130                 135                 140                 


Arg Tyr Tyr Lys Pro Glu Asp Leu Pro Glu Thr Val Pro Tyr Leu Lys 
145                 150                 155                 160 


Ile Phe Thr Val Gly His Gln Val Pro Asp Asp Glu Thr Ile Phe Lys 
                165                 170                 175     


Phe Lys His Ala Val Asn Gly Phe Leu Lys Glu Asn Lys Asp Asn Asp 
            180                 185                 190         


Lys Leu Ile Gly Val His Cys Thr His Gly Leu Asn Arg Thr Gly Tyr 
        195                 200                 205             


Leu Ile Cys Arg Tyr Leu Ile Asp Val Glu Gly Val Arg Pro Asp Asp 
    210                 215                 220                 


Ala Ile Glu Leu Phe Asn Arg Cys Arg Gly His Cys Leu Glu Arg Gln 
225                 230                 235                 240 


Asn Tyr Ile Glu Asp Leu Gln Asn Gly Pro Ile Arg Lys Asn Trp Asn 
                245                 250                 255     


Ser Ser Val Pro Arg Ser Ser Asp Phe Glu Asp Ser Ala His Leu Met 
            260                 265                 270         


Gln Pro Val His Asn Lys Pro Val Lys Gln Gly Pro Arg Tyr Asn Leu 
        275                 280                 285             


His Gln Ile Gln Gly His Ser Ala Pro Arg His Phe His Thr Gln Thr 
    290                 295                 300                 


Gln Ser Leu Gln Gln Ser Val Arg Lys Phe Ser Glu Asn Pro His Val 
305                 310                 315                 320 


Tyr Gln Arg His His Leu Pro Pro Pro Gly Pro Pro Gly Glu Asp Tyr 
                325                 330                 335     


Ser His Arg Arg Tyr Ser Trp Asn Val Lys Pro Asn Ala Ser Arg Ala 
            340                 345                 350         


Ala Gln Asp Arg Arg Arg Trp Tyr Pro Tyr Asn Tyr Ser Arg Leu Ser 
        355                 360                 365             


Tyr Pro Ala Cys Trp Glu Trp Thr Gln 
    370                 375         


<210>  3306
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP12__Homo_sapiens__NP_009171

<400>  3306

Met Leu Glu Ala Pro Gly Pro Ser Asp Gly Cys Glu Leu Ser Asn Pro 
1               5                   10                  15      


Ser Ala Ser Arg Val Ser Cys Ala Gly Gln Met Leu Glu Val Gln Pro 
            20                  25                  30          


Gly Leu Tyr Phe Gly Gly Ala Ala Ala Val Ala Glu Pro Asp His Leu 
        35                  40                  45              


Arg Glu Ala Gly Ile Thr Ala Val Leu Thr Val Asp Ser Glu Glu Pro 
    50                  55                  60                  


Ser Phe Lys Ala Gly Pro Gly Val Glu Asp Leu Trp Arg Leu Phe Val 
65                  70                  75                  80  


Pro Ala Leu Asp Lys Pro Glu Thr Asp Leu Leu Ser His Leu Asp Arg 
                85                  90                  95      


Cys Val Ala Phe Ile Gly Gln Ala Arg Ala Glu Gly Arg Ala Val Leu 
            100                 105                 110         


Val His Cys His Ala Gly Val Ser Arg Ser Val Ala Ile Ile Thr Ala 
        115                 120                 125             


Phe Leu Met Lys Thr Asp Gln Leu Pro Phe Glu Lys Ala Tyr Glu Lys 
    130                 135                 140                 


Leu Gln Ile Leu Lys Pro Glu Ala Lys Met Asn Glu Gly Phe Glu Trp 
145                 150                 155                 160 


Gln Leu Lys Leu Tyr Gln Ala Met Gly Tyr Glu Val Asp Thr Ser Ser 
                165                 170                 175     


Ala Ile Tyr Lys Gln Tyr Arg Leu Gln Lys Val Thr Glu Lys Tyr Pro 
            180                 185                 190         


Glu Leu Gln Asn Leu Pro Gln Glu Leu Phe Ala Val Asp Pro Thr Thr 
        195                 200                 205             


Val Ser Gln Gly Leu Lys Asp Glu Val Leu Tyr Lys Cys Arg Lys Cys 
    210                 215                 220                 


Arg Arg Ser Leu Phe Arg Ser Ser Ser Ile Leu Asp His Arg Glu Gly 
225                 230                 235                 240 


Ser Gly Pro Ile Ala Phe Ala His Lys Arg Met Thr Pro Ser Ser Met 
                245                 250                 255     


Leu Thr Thr Gly Arg Gln Ala Gln Cys Thr Ser Tyr Phe Ile Glu Pro 
            260                 265                 270         


Val Gln Trp Met Glu Ser Ala Leu Leu Gly Val Met Asp Gly Gln Leu 
        275                 280                 285             


Leu Cys Pro Lys Cys Ser Ala Lys Leu Gly Ser Phe Asn Trp Tyr Gly 
    290                 295                 300                 


Glu Gln Cys Ser Cys Gly Arg Trp Ile Thr Pro Ala Phe Gln Ile His 
305                 310                 315                 320 


Lys Asn Arg Val Asp Glu Met Lys Ile Leu Pro Val Leu Gly Ser Gln 
                325                 330                 335     


Thr Gly Lys Ile 
            340 


<210>  3307
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP13__Homo_sapiens__NP_001007272

<400>  3307

Met Ala Glu Thr Ser Leu Pro Glu Leu Gly Gly Glu Asp Lys Ala Thr 
1               5                   10                  15      


Pro Cys Pro Ser Ile Leu Glu Leu Glu Glu Leu Leu Arg Ala Gly Lys 
            20                  25                  30          


Ser Ser Cys Ser Arg Val Asp Glu Val Trp Pro Asn Leu Phe Ile Gly 
        35                  40                  45              


Asp Ala Ala Thr Ala Asn Asn Arg Phe Glu Leu Trp Lys Leu Gly Ile 
    50                  55                  60                  


Thr His Val Leu Asn Ala Ala His Lys Gly Leu Tyr Cys Gln Gly Gly 
65                  70                  75                  80  


Pro Asp Phe Tyr Gly Ser Ser Val Ser Tyr Leu Gly Val Pro Ala His 
                85                  90                  95      


Asp Leu Pro Asp Phe Asp Ile Ser Ala Tyr Phe Ser Ser Ala Ala Asp 
            100                 105                 110         


Phe Ile His Arg Ala Leu Asn Thr Pro Gly Ala Lys Val Leu Val His 
        115                 120                 125             


Cys Val Val Gly Val Ser Arg Ser Ala Thr Leu Val Leu Ala Tyr Leu 
    130                 135                 140                 


Met Leu His Gln Arg Leu Ser Leu Arg Gln Ala Val Ile Thr Val Arg 
145                 150                 155                 160 


Gln His Arg Trp Val Phe Pro Asn Arg Gly Phe Leu His Gln Leu Cys 
                165                 170                 175     


Arg Leu Asp Gln Gln Leu Arg Gly Ala Gly Gln Ser 
            180                 185             


<210>  3308
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP14__Homo_sapiens__NP_008957

<400>  3308

Met Ser Ser Arg Gly His Ser Thr Leu Pro Arg Thr Leu Met Ala Pro 
1               5                   10                  15      


Arg Met Ile Ser Glu Gly Asp Ile Gly Gly Ile Ala Gln Ile Thr Ser 
            20                  25                  30          


Ser Leu Phe Leu Gly Arg Gly Ser Val Ala Ser Asn Arg His Leu Leu 
        35                  40                  45              


Gln Ala Arg Gly Ile Thr Cys Ile Val Asn Ala Thr Ile Glu Ile Pro 
    50                  55                  60                  


Asn Phe Asn Trp Pro Gln Phe Glu Tyr Val Lys Val Pro Leu Ala Asp 
65                  70                  75                  80  


Met Pro His Ala Pro Ile Gly Leu Tyr Phe Asp Thr Val Ala Asp Lys 
                85                  90                  95      


Ile His Ser Val Ser Arg Lys His Gly Ala Thr Leu Val His Cys Ala 
            100                 105                 110         


Ala Gly Val Ser Arg Ser Ala Thr Leu Cys Ile Ala Tyr Leu Met Lys 
        115                 120                 125             


Phe His Asn Val Cys Leu Leu Glu Ala Tyr Asn Trp Val Lys Ala Arg 
    130                 135                 140                 


Arg Pro Val Ile Arg Pro Asn Val Gly Phe Trp Arg Gln Leu Ile Asp 
145                 150                 155                 160 


Tyr Glu Arg Gln Leu Phe Gly Lys Ser Thr Val Lys Met Val Gln Thr 
                165                 170                 175     


Pro Tyr Gly Ile Val Pro Asp Val Tyr Glu Lys Glu Ser Arg His Leu 
            180                 185                 190         


Met Pro Tyr Trp Gly Ile 
        195             


<210>  3309
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP15__Homo_sapiens__NP_542178

<400>  3309

Met Gly Asn Gly Met Thr Lys Val Leu Pro Gly Leu Tyr Leu Gly Asn 
1               5                   10                  15      


Phe Ile Asp Ala Lys Asp Leu Asp Gln Leu Gly Arg Asn Lys Ile Thr 
            20                  25                  30          


His Ile Ile Ser Ile His Glu Ser Pro Gln Pro Leu Leu Gln Asp Ile 
        35                  40                  45              


Thr Tyr Leu Arg Ile Pro Val Ala Asp Thr Pro Glu Val Pro Ile Lys 
    50                  55                  60                  


Lys His Phe Lys Glu Cys Ile Asn Phe Ile His Cys Cys Arg Leu Asn 
65                  70                  75                  80  


Gly Gly Asn Cys Leu Val His Cys Phe Ala Gly Ile Ser Arg Ser Thr 
                85                  90                  95      


Thr Ile Val Thr Ala Tyr Val Met Thr Val Thr Gly Leu Gly Trp Arg 
            100                 105                 110         


Asp Val Leu Glu Ala Ile Lys Ala Thr Arg Pro Ile Ala Asn Pro Asn 
        115                 120                 125             


Pro Gly Phe Arg Gln Gln Leu Glu Glu Phe Gly Trp Ala Ser Ser Gln 
    130                 135                 140                 


Lys Leu Arg Arg Gln Leu Glu Glu Arg Phe Gly Glu Ser Pro Phe Arg 
145                 150                 155                 160 


Asp Glu Glu Glu Leu Arg Ala Leu Leu Pro Leu Cys Lys Arg Cys Arg 
                165                 170                 175     


Gln Gly Ser Ala Thr Ser Ala Ser Ser Ala Gly Pro His Ser Ala Ala 
            180                 185                 190         


Ser Glu Gly Thr Val Gln Arg Leu Val Pro Arg Thr Pro Arg Glu Ala 
        195                 200                 205             


His Arg Pro Leu Pro Leu Leu Ala Arg Val Lys Gln Thr Phe Ser Cys 
    210                 215                 220                 


Leu Pro Arg Cys Leu Ser Arg Lys Gly Gly Lys 
225                 230                 235 


<210>  3310
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP16__Homo_sapiens__XP_005253545

<400>  3310

Met Leu Pro Leu Ser Leu Gln Thr Val Phe Ser Leu Tyr Phe Trp Val 
1               5                   10                  15      


Asn Trp Arg Arg Ala Ser Thr Leu Phe Thr Cys Leu Gln Glu Leu Met 
            20                  25                  30          


Gln Gln Asn Gly Ile Gly Tyr Val Leu Asn Ala Ser Asn Thr Cys Pro 
        35                  40                  45              


Lys Pro Asp Phe Ile Pro Glu Ser His Phe Leu Arg Val Pro Val Asn 
    50                  55                  60                  


Asp Ser Phe Cys Glu Lys Ile Leu Pro Trp Leu Asp Lys Ser Val Asp 
65                  70                  75                  80  


Phe Ile Glu Lys Ala Lys Ala Ser Asn Gly Cys Val Leu Val His Cys 
                85                  90                  95      


Leu Ala Gly Ile Ser Arg Ser Ala Thr Ile Ala Ile Ala Tyr Ile Met 
            100                 105                 110         


Lys Arg Met Asp Met Ser Leu Asp Glu Ala Tyr Arg Phe Val Lys Glu 
        115                 120                 125             


Lys Arg Pro Thr Ile Ser Pro Asn Phe Asn Phe Leu Gly Gln Leu Leu 
    130                 135                 140                 


Asp Tyr Glu Lys Lys Ile Lys Asn Gln Thr Gly Ala Ser Gly Pro Lys 
145                 150                 155                 160 


Ser Lys Leu Lys Leu Leu His Leu Glu Lys Pro Asn Glu Pro Val Pro 
                165                 170                 175     


Ala Val Ser Glu Gly Gly Gln Lys Ser Glu Thr Pro Leu Ser Pro Pro 
            180                 185                 190         


Cys Ala Asp Ser Ala Thr Ser Glu Ala Ala Gly Gln Arg Pro Val His 
        195                 200                 205             


Pro Ala Ser Val Pro Ser Val Pro Ser Val Gln Pro Ser Leu Leu Glu 
    210                 215                 220                 


Asp Ser Pro Leu Val Gln Ala Leu Ser Gly Leu His Leu Ser Ala Asp 
225                 230                 235                 240 


Arg Leu Glu Asp Ser Asn Lys Leu Lys Arg Ser Phe Ser Leu Asp Ile 
                245                 250                 255     


Lys Ser Val Ser Tyr Ser Ala Ser Met Ala Ala Ser Leu His Gly Phe 
            260                 265                 270         


Ser Ser Ser Glu Asp Ala Leu Glu Tyr Tyr Lys Pro Ser Thr Thr Leu 
        275                 280                 285             


Asp Gly Thr Asn Lys Leu Cys Gln Phe Ser Pro Val Gln Glu Leu Ser 
    290                 295                 300                 


Glu Gln Thr Pro Glu Thr Ser Pro Asp Lys Glu Glu Ala Ser Ile Pro 
305                 310                 315                 320 


Lys Lys Leu Gln Thr Ala Arg Pro Ser Asp Ser Gln Ser Lys Arg Leu 
                325                 330                 335     


His Ser Val Arg Thr Ser Ser Ser Gly Thr Ala Gln Arg Ser Leu Leu 
            340                 345                 350         


Ser Pro Leu His Arg Ser Gly Ser Val Glu Asp Asn Tyr His Thr Ser 
        355                 360                 365             


Phe Leu Phe Gly Leu Ser Thr Ser Gln Gln His Leu Thr Lys Ser Ala 
    370                 375                 380                 


Gly Leu Gly Leu Lys Gly Trp His Ser Asp Ile Leu Ala Pro Gln Thr 
385                 390                 395                 400 


Ser Thr Pro Ser Leu Thr Ser Ser Trp Tyr Phe Ala Thr Glu Ser Ser 
                405                 410                 415     


His Phe Tyr Ser Ala Ser Ala Ile Tyr Gly Gly Ser Ala Ser Tyr Ser 
            420                 425                 430         


Ala Tyr Ser Cys Ser Gln Leu Pro Thr Cys Gly Asp Gln Val Tyr Ser 
        435                 440                 445             


Val Arg Arg Arg Gln Lys Pro Ser Asp Arg Ala Asp Ser Arg Arg Ser 
    450                 455                 460                 


Trp His Glu Glu Ser Pro Phe Glu Lys Gln Phe Lys Arg Arg Ser Cys 
465                 470                 475                 480 


Gln Met Glu Phe Gly Glu Ser Ile Met Ser Glu Asn Arg Ser Arg Glu 
                485                 490                 495     


Glu Leu Gly Lys Val Gly Ser Gln Ser Ser Phe Ser Gly Ser Met Glu 
            500                 505                 510         


Ile Ile Glu Val Ser 
        515         


<210>  3311
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP18__Homo_sapiens__NP_001291723

<400>  3311

Met Thr Ala Pro Ser Cys Ala Phe Pro Val Gln Phe Arg Gln Pro Ser 
1               5                   10                  15      


Val Ser Gly Leu Ser Gln Ile Thr Lys Ser Leu Tyr Ile Ser Asn Gly 
            20                  25                  30          


Val Ala Ala Asn Asn Lys Leu Met Leu Ser Ser Asn Gln Ile Thr Met 
        35                  40                  45              


Val Ile Asn Val Ser Val Glu Val Val Asn Thr Leu Tyr Glu Asp Ile 
    50                  55                  60                  


Gln Tyr Met Gln Val Pro Val Ala Asp Ser Pro Asn Ser Arg Leu Cys 
65                  70                  75                  80  


Asp Phe Phe Asp Pro Ile Ala Asp His Ile His Ser Val Glu Met Lys 
                85                  90                  95      


Gln Gly Arg Thr Leu Leu His Cys Ala Ala Gly Val Ser Arg Ser Ala 
            100                 105                 110         


Ala Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ala Met Ser Leu Leu 
        115                 120                 125             


Asp Ala His Thr Trp Thr Lys Ser Cys Arg Pro Ile Ile Arg Pro Asn 
    130                 135                 140                 


Ser Gly Phe Trp Glu Gln Leu Ile His Tyr Glu Phe Gln Leu Phe Gly 
145                 150                 155                 160 


Lys Asn Thr Val His Met Val Ser Ser Pro Val Gly Met Ile Pro Asp 
                165                 170                 175     


Ile Tyr Glu Lys Glu Val Arg Leu Met Ile Pro Leu 
            180                 185             


<210>  3312
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP1__Homo_sapiens__NP_004408

<400>  3312

Met Val Met Glu Val Gly Thr Leu Asp Ala Gly Gly Leu Arg Ala Leu 
1               5                   10                  15      


Leu Gly Glu Arg Ala Ala Gln Cys Leu Leu Leu Asp Cys Arg Ser Phe 
            20                  25                  30          


Phe Ala Phe Asn Ala Gly His Ile Ala Gly Ser Val Asn Val Arg Phe 
        35                  40                  45              


Ser Thr Ile Val Arg Arg Arg Ala Lys Gly Ala Met Gly Leu Glu His 
    50                  55                  60                  


Ile Val Pro Asn Ala Glu Leu Arg Gly Arg Leu Leu Ala Gly Ala Tyr 
65                  70                  75                  80  


His Ala Val Val Leu Leu Asp Glu Arg Ser Ala Ala Leu Asp Gly Ala 
                85                  90                  95      


Lys Arg Asp Gly Thr Leu Ala Leu Ala Ala Gly Ala Leu Cys Arg Glu 
            100                 105                 110         


Ala Arg Ala Ala Gln Val Phe Phe Leu Lys Gly Gly Tyr Glu Ala Phe 
        115                 120                 125             


Ser Ala Ser Cys Pro Glu Leu Cys Ser Lys Gln Ser Thr Pro Met Gly 
    130                 135                 140                 


Leu Ser Leu Pro Leu Ser Thr Ser Val Pro Asp Ser Ala Glu Ser Gly 
145                 150                 155                 160 


Cys Ser Ser Cys Ser Thr Pro Leu Tyr Asp Gln Gly Gly Pro Val Glu 
                165                 170                 175     


Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr His Ala Ser Arg Lys 
            180                 185                 190         


Asp Met Leu Asp Ala Leu Gly Ile Thr Ala Leu Ile Asn Val Ser Ala 
        195                 200                 205             


Asn Cys Pro Asn His Phe Glu Gly His Tyr Gln Tyr Lys Ser Ile Pro 
    210                 215                 220                 


Val Glu Asp Asn His Lys Ala Asp Ile Ser Ser Trp Phe Asn Glu Ala 
225                 230                 235                 240 


Ile Asp Phe Ile Asp Ser Ile Lys Asn Ala Gly Gly Arg Val Phe Val 
                245                 250                 255     


His Cys Gln Ala Gly Ile Ser Arg Ser Ala Thr Ile Cys Leu Ala Tyr 
            260                 265                 270         


Leu Met Arg Thr Asn Arg Val Lys Leu Asp Glu Ala Phe Glu Phe Val 
        275                 280                 285             


Lys Gln Arg Arg Ser Ile Ile Ser Pro Asn Phe Ser Phe Met Gly Gln 
    290                 295                 300                 


Leu Leu Gln Phe Glu Ser Gln Val Leu Ala Pro His Cys Ser Ala Glu 
305                 310                 315                 320 


Ala Gly Ser Pro Ala Met Ala Val Leu Asp Arg Gly Thr Ser Thr Thr 
                325                 330                 335     


Thr Val Phe Asn Phe Pro Val Ser Ile Pro Val His Ser Thr Asn Ser 
            340                 345                 350         


Ala Leu Ser Tyr Leu Gln Ser Pro Ile Thr Thr Ser Pro Ser Cys 
        355                 360                 365         


<210>  3313
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP21__Homo_sapiens__NP_071359

<400>  3313

Met Thr Ala Ser Ala Ser Ser Phe Ser Ser Ser Gln Gly Val Gln Gln 
1               5                   10                  15      


Pro Ser Ile Tyr Ser Phe Ser Gln Ile Thr Arg Ser Leu Phe Leu Ser 
            20                  25                  30          


Asn Gly Val Ala Ala Asn Asp Lys Leu Leu Leu Ser Ser Asn Arg Ile 
        35                  40                  45              


Thr Ala Ile Val Asn Ala Ser Val Glu Val Val Asn Val Phe Phe Glu 
    50                  55                  60                  


Gly Ile Gln Tyr Ile Lys Val Pro Val Thr Asp Ala Arg Asp Ser Arg 
65                  70                  75                  80  


Leu Tyr Asp Phe Phe Asp Pro Ile Ala Asp Leu Ile His Thr Ile Asp 
                85                  90                  95      


Met Arg Gln Gly Arg Thr Leu Leu His Cys Met Ala Gly Val Ser Arg 
            100                 105                 110         


Ser Ala Ser Leu Cys Leu Ala Tyr Leu Met Lys Tyr His Ser Met Ser 
        115                 120                 125             


Leu Leu Asp Ala His Thr Trp Thr Lys Ser Arg Arg Pro Ile Ile Arg 
    130                 135                 140                 


Pro Asn Asn Gly Phe Trp Glu Gln Leu Ile Asn Tyr Glu Phe Lys Leu 
145                 150                 155                 160 


Phe Asn Asn Asn Thr Val Arg Met Ile Asn Ser Pro Val Gly Asn Ile 
                165                 170                 175     


Pro Asp Ile Tyr Glu Lys Asp Leu Arg Met Met Ile Ser Met 
            180                 185                 190 


<210>  3314
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP22__Homo_sapiens__NP_001273484

<400>  3314

Met Gly Asn Gly Met Asn Lys Ile Leu Pro Gly Leu Tyr Ile Gly Asn 
1               5                   10                  15      


Phe Lys Asp Ala Arg Asp Ala Glu Gln Leu Ser Lys Asn Lys Val Thr 
            20                  25                  30          


His Ile Leu Ser Val His Asp Ser Ala Arg Pro Met Leu Glu Gly Val 
        35                  40                  45              


Lys Tyr Leu Cys Ile Pro Ala Ala Asp Ser Pro Ser Gln Asn Leu Thr 
    50                  55                  60                  


Arg His Phe Lys Glu Ser Ile Lys Phe Ile His Glu Cys Arg Leu Arg 
65                  70                  75                  80  


Gly Glu Ser Cys Leu Val His Cys Leu Ala Gly Val Ser Arg Ser Val 
                85                  90                  95      


Thr Leu Val Ile Ala Tyr Ile Met Thr Val Thr Asp Phe Gly Trp Glu 
            100                 105                 110         


Asp Ala Leu His Thr Val Arg Ala Gly Arg Ser Cys Ala Asn Pro Asn 
        115                 120                 125             


Val Gly Phe Gln Arg Gln Leu Gln Glu Phe Glu Lys His Glu Val His 
    130                 135                 140                 


Gln Tyr Arg Gln Trp Leu Lys Glu Glu Tyr Gly Glu Ser Pro Leu Gln 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Lys Asn Ile Leu Gly Lys Tyr Lys Glu Gln Gly 
                165                 170                 175     


Arg Thr Glu Pro Gln Pro Gly Ala Arg Arg Trp Ser Ser Phe Pro Ala 
            180                 185                 190         


Leu Ala Pro Leu Thr Tyr Asp Asn Tyr Thr Thr Glu Thr 
        195                 200                 205 


<210>  3315
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP23__Homo_sapiens__NP_060293

<400>  3315

Met Gly Val Gln Pro Pro Asn Phe Ser Trp Val Leu Pro Gly Arg Leu 
1               5                   10                  15      


Ala Gly Leu Ala Leu Pro Arg Leu Pro Ala His Tyr Gln Phe Leu Leu 
            20                  25                  30          


Asp Leu Gly Val Arg His Leu Val Ser Leu Thr Glu Arg Gly Pro Pro 
        35                  40                  45              


His Ser Asp Ser Cys Pro Gly Leu Thr Leu His Arg Leu Arg Ile Pro 
    50                  55                  60                  


Asp Phe Cys Pro Pro Ala Pro Asp Gln Ile Asp Arg Phe Val Gln Ile 
65                  70                  75                  80  


Val Asp Glu Ala Asn Ala Arg Gly Glu Ala Val Gly Val His Cys Ala 
                85                  90                  95      


Leu Gly Phe Gly Arg Thr Gly Thr Met Leu Ala Cys Tyr Leu Val Lys 
            100                 105                 110         


Glu Arg Gly Leu Ala Ala Gly Asp Ala Ile Ala Glu Ile Arg Arg Leu 
        115                 120                 125             


Arg Pro Gly Ser Ile Glu Thr Tyr Glu Gln Glu Lys Ala Val Phe Gln 
    130                 135                 140                 


Phe Tyr Gln Arg Thr Lys 
145                 150 


<210>  3316
<211>  1158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP27__Homo_sapiens__XP_005245660

<400>  3316

Met Ala Thr Arg Lys Asp Thr Glu Glu Glu Gln Val Val Pro Ser Glu 
1               5                   10                  15      


Glu Asp Glu Ala Asn Val Arg Ala Val Gln Ala His Tyr Leu Arg Ser 
            20                  25                  30          


Pro Ser Pro Ser Gln Tyr Ser Met Val Ser Asp Ala Glu Thr Glu Ser 
        35                  40                  45              


Ile Phe Met Glu Pro Ile His Leu Ser Ser Ala Ile Ala Ala Lys Gln 
    50                  55                  60                  


Ile Ile Asn Glu Glu Leu Lys Pro Pro Gly Val Arg Ala Asp Ala Glu 
65                  70                  75                  80  


Cys Pro Gly Met Leu Glu Ser Ala Glu Gln Leu Leu Val Glu Asp Leu 
                85                  90                  95      


Tyr Asn Arg Val Arg Glu Lys Met Asp Asp Thr Ser Leu Tyr Asn Thr 
            100                 105                 110         


Pro Cys Val Leu Asp Leu Gln Arg Ala Leu Val Gln Asp Arg Gln Glu 
        115                 120                 125             


Ala Pro Trp Asn Glu Val Asp Glu Val Trp Pro Asn Val Phe Ile Ala 
    130                 135                 140                 


Glu Lys Ser Val Ala Val Asn Lys Gly Arg Leu Lys Arg Leu Gly Ile 
145                 150                 155                 160 


Thr His Ile Leu Asn Ala Ala His Gly Thr Gly Val Tyr Thr Gly Pro 
                165                 170                 175     


Glu Phe Tyr Thr Gly Leu Glu Ile Gln Tyr Leu Gly Val Glu Val Asp 
            180                 185                 190         


Asp Phe Pro Glu Val Asp Ile Ser Gln His Phe Arg Lys Ala Ser Glu 
        195                 200                 205             


Phe Leu Asp Glu Ala Leu Leu Thr Tyr Arg Gly Lys Val Leu Val Ser 
    210                 215                 220                 


Ser Glu Met Gly Ile Ser Arg Ser Ala Val Leu Val Val Ala Tyr Leu 
225                 230                 235                 240 


Met Ile Phe His Asn Met Ala Ile Leu Glu Ala Leu Met Thr Val Arg 
                245                 250                 255     


Lys Lys Arg Ala Ile Tyr Pro Asn Glu Gly Phe Leu Lys Gln Leu Arg 
            260                 265                 270         


Glu Leu Asn Glu Lys Leu Met Glu Glu Arg Glu Glu Asp Tyr Gly Arg 
        275                 280                 285             


Glu Gly Gly Ser Ala Glu Ala Glu Glu Gly Glu Gly Thr Gly Ser Met 
    290                 295                 300                 


Leu Gly Ala Arg Val His Ala Leu Thr Val Glu Glu Glu Asp Asp Ser 
305                 310                 315                 320 


Ala Ser His Leu Ser Gly Ser Ser Leu Gly Lys Ala Thr Gln Ala Ser 
                325                 330                 335     


Lys Pro Leu Thr Leu Ile Asp Glu Glu Glu Glu Glu Lys Leu Tyr Glu 
            340                 345                 350         


Gln Trp Lys Lys Gly Gln Gly Leu Leu Ser Asp Lys Val Pro Gln Asp 
        355                 360                 365             


Gly Gly Gly Trp Arg Ser Ala Ser Ser Gly Gln Gly Gly Glu Glu Leu 
    370                 375                 380                 


Glu Asp Glu Asp Val Glu Arg Ile Ile Gln Glu Trp Gln Ser Arg Asn 
385                 390                 395                 400 


Glu Arg Tyr Gln Ala Glu Gly Tyr Arg Arg Trp Gly Arg Glu Glu Glu 
                405                 410                 415     


Lys Glu Glu Glu Ser Asp Ala Gly Ser Ser Val Gly Arg Arg Arg Arg 
            420                 425                 430         


Thr Leu Ser Glu Ser Ser Ala Trp Glu Ser Val Ser Ser His Asp Ile 
        435                 440                 445             


Trp Val Leu Lys Gln Gln Leu Glu Leu Asn Arg Pro Asp His Gly Arg 
    450                 455                 460                 


Arg Arg Arg Ala Asp Ser Met Ser Ser Glu Ser Thr Trp Asp Ala Trp 
465                 470                 475                 480 


Asn Glu Arg Leu Leu Glu Ile Glu Lys Glu Ala Ser Arg Arg Tyr His 
                485                 490                 495     


Ala Lys Ser Lys Arg Glu Glu Ala Ala Asp Arg Ser Ser Glu Ala Gly 
            500                 505                 510         


Ser Arg Val Arg Glu Asp Asp Glu Asp Ser Val Gly Ser Glu Ala Ser 
        515                 520                 525             


Ser Phe Tyr Asn Phe Cys Ser Arg Asn Lys Asp Lys Leu Thr Ala Leu 
    530                 535                 540                 


Glu Arg Trp Lys Ile Lys Arg Ile Gln Phe Gly Phe His Lys Lys Asp 
545                 550                 555                 560 


Leu Gly Ala Gly Asp Ser Ser Gly Glu Pro Gly Ala Glu Glu Ala Val 
                565                 570                 575     


Gly Glu Lys Asn Pro Ser Asp Val Ser Leu Thr Ala Tyr Gln Ala Trp 
            580                 585                 590         


Lys Leu Lys His Gln Lys Lys Val Gly Ser Glu Asn Lys Glu Glu Val 
        595                 600                 605             


Val Glu Leu Ser Lys Gly Glu Asp Ser Ala Leu Ala Lys Lys Arg Gln 
    610                 615                 620                 


Arg Arg Leu Glu Leu Leu Glu Arg Ser Arg Gln Thr Leu Glu Glu Ser 
625                 630                 635                 640 


Gln Ser Met Ala Ser Trp Glu Ala Asp Ser Ser Thr Ala Ser Gly Ser 
                645                 650                 655     


Ile Pro Leu Ser Ala Phe Trp Ser Ala Asp Pro Ser Val Ser Ala Asp 
            660                 665                 670         


Gly Asp Thr Thr Ser Val Leu Ser Thr Gln Ser His Arg Ser His Leu 
        675                 680                 685             


Ser Gln Ala Ala Ser Asn Ile Ala Gly Cys Ser Thr Ser Asn Pro Thr 
    690                 695                 700                 


Thr Pro Leu Pro Asn Leu Pro Val Gly Pro Gly Asp Thr Ile Ser Ile 
705                 710                 715                 720 


Ala Ser Ile Gln Asn Trp Ile Ala Asn Val Val Ser Glu Thr Leu Ala 
                725                 730                 735     


Gln Lys Gln Asn Glu Met Leu Leu Leu Ser Arg Ser Pro Ser Val Ala 
            740                 745                 750         


Ser Met Lys Ala Val Pro Ala Ala Ser Cys Leu Gly Asp Asp Gln Val 
        755                 760                 765             


Ser Met Leu Ser Gly His Ser Ser Ser Ser Leu Gly Gly Cys Leu Leu 
    770                 775                 780                 


Pro Gln Ser Gln Ala Arg Pro Ser Ser Asp Met Gln Ser Val Leu Ser 
785                 790                 795                 800 


Cys Asn Thr Thr Leu Ser Ser Pro Ala Glu Ser Cys Arg Ser Lys Val 
                805                 810                 815     


Arg Gly Thr Ser Lys Pro Ile Phe Ser Leu Phe Ala Asp Asn Val Asp 
            820                 825                 830         


Leu Lys Glu Leu Gly Arg Lys Glu Lys Glu Met Gln Met Glu Leu Arg 
        835                 840                 845             


Glu Lys Met Ser Glu Tyr Lys Met Glu Lys Leu Ala Ser Asp Asn Lys 
    850                 855                 860                 


Arg Ser Ser Leu Phe Lys Lys Lys Lys Val Lys Glu Asp Glu Asp Asp 
865                 870                 875                 880 


Gly Val Gly Asp Gly Asp Glu Asp Thr Asp Ser Ala Ile Gly Ser Phe 
                885                 890                 895     


Arg Tyr Ser Ser Arg Ser Asn Ser Gln Lys Pro Glu Thr Asp Thr Cys 
            900                 905                 910         


Ser Ser Leu Ala Val Cys Asp His Tyr Ala Ser Gly Ser Arg Val Gly 
        915                 920                 925             


Lys Glu Met Asp Ser Ser Ile Asn Lys Trp Leu Ser Gly Leu Arg Thr 
    930                 935                 940                 


Glu Glu Lys Pro Pro Phe Gln Ser Asp Trp Ser Gly Ser Ser Arg Gly 
945                 950                 955                 960 


Lys Tyr Thr Arg Ser Ser Leu Leu Arg Glu Thr Glu Ser Lys Ser Ser 
                965                 970                 975     


Ser Tyr Lys Phe Ser Lys Ser Gln Ser Glu Glu Gln Asp Thr Ser Ser 
            980                 985                 990         


Tyr His Glu Ala Asn Gly Asn Ser  Val Arg Ser Thr Ser  Arg Phe Ser 
        995                 1000                 1005             


Ser Ser  Ser Thr Arg Glu Gly  Arg Glu Met His Lys  Phe Ser Arg 
    1010                 1015                 1020             


Ser Thr  Tyr Asn Glu Thr Ser  Ser Ser Arg Glu Glu  Ser Pro Glu 
    1025                 1030                 1035             


Pro Tyr  Phe Phe Arg Arg Thr  Pro Glu Ser Ser Glu  Arg Glu Glu 
    1040                 1045                 1050             


Ser Pro  Glu Pro Gln Arg Pro  Asn Trp Ala Arg Ser  Arg Asp Trp 
    1055                 1060                 1065             


Glu Asp  Val Glu Glu Ser Ser  Lys Ser Asp Phe Ser  Glu Phe Gly 
    1070                 1075                 1080             


Ala Lys  Arg Lys Phe Thr Gln  Ser Phe Met Arg Ser  Glu Glu Glu 
    1085                 1090                 1095             


Gly Glu  Lys Glu Arg Thr Glu  Asn Arg Glu Glu Gly  Arg Phe Ala 
    1100                 1105                 1110             


Ser Gly  Arg Arg Ser Gln Tyr  Arg Arg Ser Thr Asp  Arg Glu Glu 
    1115                 1120                 1125             


Glu Glu  Glu Met Asp Asp Glu  Ala Ile Ile Ala Ala  Trp Arg Arg 
    1130                 1135                 1140             


Arg Gln  Glu Glu Thr Arg Thr  Lys Leu Gln Lys Arg  Arg Glu Asp 
    1145                 1150                 1155             


<210>  3317
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP28__Homo_sapiens__NP_001028747

<400>  3317

Met Gly Pro Ala Glu Ala Gly Arg Arg Gly Ala Ala Ser Pro Val Pro 
1               5                   10                  15      


Pro Pro Leu Val Arg Val Ala Pro Ser Leu Phe Leu Gly Ser Ala Arg 
            20                  25                  30          


Ala Ala Gly Ala Glu Glu Gln Leu Ala Arg Ala Gly Val Thr Leu Cys 
        35                  40                  45              


Val Asn Val Ser Arg Gln Gln Pro Gly Pro Arg Ala Pro Gly Val Ala 
    50                  55                  60                  


Glu Leu Arg Val Pro Val Phe Asp Asp Pro Ala Glu Asp Leu Leu Ala 
65                  70                  75                  80  


His Leu Glu Pro Thr Cys Ala Ala Met Glu Ala Ala Val Arg Ala Gly 
                85                  90                  95      


Gly Ala Cys Leu Val Tyr Cys Lys Asn Gly Arg Ser Arg Ser Ala Ala 
            100                 105                 110         


Val Cys Thr Ala Tyr Leu Met Arg His Arg Gly Leu Ser Leu Ala Lys 
        115                 120                 125             


Ala Phe Gln Met Val Lys Ser Ala Arg Pro Val Ala Glu Pro Asn Pro 
    130                 135                 140                 


Gly Phe Trp Ser Gln Leu Gln Lys Tyr Glu Glu Ala Leu Gln Ala Gln 
145                 150                 155                 160 


Ser Cys Leu Gln Gly Glu Pro Pro Ala Leu Gly Leu Gly Pro Glu Ala 
                165                 170                 175     


<210>  3318
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP2__Homo_sapiens__NP_004409

<400>  3318

Met Gly Leu Glu Ala Ala Arg Glu Leu Glu Cys Ala Ala Leu Gly Thr 
1               5                   10                  15      


Leu Leu Arg Asp Pro Arg Glu Ala Glu Arg Thr Leu Leu Leu Asp Cys 
            20                  25                  30          


Arg Pro Phe Leu Ala Phe Cys Arg Arg His Val Arg Ala Ala Arg Pro 
        35                  40                  45              


Val Pro Trp Asn Ala Leu Leu Arg Arg Arg Ala Arg Gly Pro Pro Ala 
    50                  55                  60                  


Ala Val Leu Ala Cys Leu Leu Pro Asp Arg Ala Leu Arg Thr Arg Leu 
65                  70                  75                  80  


Val Arg Gly Glu Leu Ala Arg Ala Val Val Leu Asp Glu Gly Ser Ala 
                85                  90                  95      


Ser Val Ala Glu Leu Arg Pro Asp Ser Pro Ala His Val Leu Leu Ala 
            100                 105                 110         


Ala Leu Leu His Glu Thr Arg Ala Gly Pro Thr Ala Val Tyr Phe Leu 
        115                 120                 125             


Arg Gly Gly Phe Asp Gly Phe Gln Gly Cys Cys Pro Asp Leu Cys Ser 
    130                 135                 140                 


Glu Ala Pro Ala Pro Ala Leu Pro Pro Thr Gly Asp Lys Thr Ser Arg 
145                 150                 155                 160 


Ser Asp Ser Arg Ala Pro Val Tyr Asp Gln Gly Gly Pro Val Glu Ile 
                165                 170                 175     


Leu Pro Tyr Leu Phe Leu Gly Ser Cys Ser His Ser Ser Asp Leu Gln 
            180                 185                 190         


Gly Leu Gln Ala Cys Gly Ile Thr Ala Val Leu Asn Val Ser Ala Ser 
        195                 200                 205             


Cys Pro Asn His Phe Glu Gly Leu Phe Arg Tyr Lys Ser Ile Pro Val 
    210                 215                 220                 


Glu Asp Asn Gln Met Val Glu Ile Ser Ala Trp Phe Gln Glu Ala Ile 
225                 230                 235                 240 


Gly Phe Ile Asp Trp Val Lys Asn Ser Gly Gly Arg Val Leu Val His 
                245                 250                 255     


Cys Gln Ala Gly Ile Ser Arg Ser Ala Thr Ile Cys Leu Ala Tyr Leu 
            260                 265                 270         


Met Gln Ser Arg Arg Val Arg Leu Asp Glu Ala Phe Asp Phe Val Lys 
        275                 280                 285             


Gln Arg Arg Gly Val Ile Ser Pro Asn Phe Ser Phe Met Gly Gln Leu 
    290                 295                 300                 


Leu Gln Phe Glu Thr Gln Val Leu Cys His 
305                 310                 


<210>  3319
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP3__Homo_sapiens__NP_004081

<400>  3319

Met Ser Gly Ser Phe Glu Leu Ser Val Gln Asp Leu Asn Asp Leu Leu 
1               5                   10                  15      


Ser Asp Gly Ser Gly Cys Tyr Ser Leu Pro Ser Gln Pro Cys Asn Glu 
            20                  25                  30          


Val Thr Pro Arg Ile Tyr Val Gly Asn Ala Ser Val Ala Gln Asp Ile 
        35                  40                  45              


Pro Lys Leu Gln Lys Leu Gly Ile Thr His Val Leu Asn Ala Ala Glu 
    50                  55                  60                  


Gly Arg Ser Phe Met His Val Asn Thr Asn Ala Asn Phe Tyr Lys Asp 
65                  70                  75                  80  


Ser Gly Ile Thr Tyr Leu Gly Ile Lys Ala Asn Asp Thr Gln Glu Phe 
                85                  90                  95      


Asn Leu Ser Ala Tyr Phe Glu Arg Ala Ala Asp Phe Ile Asp Gln Ala 
            100                 105                 110         


Leu Ala Gln Lys Asn Gly Arg Val Leu Val His Cys Arg Glu Gly Tyr 
        115                 120                 125             


Ser Arg Ser Pro Thr Leu Val Ile Ala Tyr Leu Met Met Arg Gln Lys 
    130                 135                 140                 


Met Asp Val Lys Ser Ala Leu Ser Ile Val Arg Gln Asn Arg Glu Ile 
145                 150                 155                 160 


Gly Pro Asn Asp Gly Phe Leu Ala Gln Leu Cys Gln Leu Asn Asp Arg 
                165                 170                 175     


Leu Ala Lys Glu Gly Lys Leu Lys Pro 
            180                 185 


<210>  3320
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP4__Homo_sapiens__NP_001385

<400>  3320

Met Val Thr Met Glu Glu Leu Arg Glu Met Asp Cys Ser Val Leu Lys 
1               5                   10                  15      


Arg Leu Met Asn Arg Asp Glu Asn Gly Gly Gly Ala Gly Gly Ser Gly 
            20                  25                  30          


Ser His Gly Thr Leu Gly Leu Pro Ser Gly Gly Lys Cys Leu Leu Leu 
        35                  40                  45              


Asp Cys Arg Pro Phe Leu Ala His Ser Ala Gly Tyr Ile Leu Gly Ser 
    50                  55                  60                  


Val Asn Val Arg Cys Asn Thr Ile Val Arg Arg Arg Ala Lys Gly Ser 
65                  70                  75                  80  


Val Ser Leu Glu Gln Ile Leu Pro Ala Glu Glu Glu Val Arg Ala Arg 
                85                  90                  95      


Leu Arg Ser Gly Leu Tyr Ser Ala Val Ile Val Tyr Asp Glu Arg Ser 
            100                 105                 110         


Pro Arg Ala Glu Ser Leu Arg Glu Asp Ser Thr Val Ser Leu Val Val 
        115                 120                 125             


Gln Ala Leu Arg Arg Asn Ala Glu Arg Thr Asp Ile Cys Leu Leu Lys 
    130                 135                 140                 


Gly Gly Tyr Glu Arg Phe Ser Ser Glu Tyr Pro Glu Phe Cys Ser Lys 
145                 150                 155                 160 


Thr Lys Ala Leu Ala Ala Ile Pro Pro Pro Val Pro Pro Ser Ala Thr 
                165                 170                 175     


Glu Pro Leu Asp Leu Gly Cys Ser Ser Cys Gly Thr Pro Leu His Asp 
            180                 185                 190         


Gln Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala 
        195                 200                 205             


Tyr His Ala Ala Arg Arg Asp Met Leu Asp Ala Leu Gly Ile Thr Ala 
    210                 215                 220                 


Leu Leu Asn Val Ser Ser Asp Cys Pro Asn His Phe Glu Gly His Tyr 
225                 230                 235                 240 


Gln Tyr Lys Cys Ile Pro Val Glu Asp Asn His Lys Ala Asp Ile Ser 
                245                 250                 255     


Ser Trp Phe Met Glu Ala Ile Glu Tyr Ile Asp Ala Val Lys Asp Cys 
            260                 265                 270         


Arg Gly Arg Val Leu Val His Cys Gln Ala Gly Ile Ser Arg Ser Ala 
        275                 280                 285             


Thr Ile Cys Leu Ala Tyr Leu Met Met Lys Lys Arg Val Arg Leu Glu 
    290                 295                 300                 


Glu Ala Phe Glu Phe Val Lys Gln Arg Arg Ser Ile Ile Ser Pro Asn 
305                 310                 315                 320 


Phe Ser Phe Met Gly Gln Leu Leu Gln Phe Glu Ser Gln Val Leu Ala 
                325                 330                 335     


Thr Ser Cys Ala Ala Glu Ala Ala Ser Pro Ser Gly Pro Leu Arg Glu 
            340                 345                 350         


Arg Gly Lys Thr Pro Ala Thr Pro Thr Ser Gln Phe Val Phe Ser Phe 
        355                 360                 365             


Pro Val Ser Val Gly Val His Ser Ala Pro Ser Ser Leu Pro Tyr Leu 
    370                 375                 380                 


His Ser Pro Ile Thr Thr Ser Pro Ser Cys 
385                 390                 


<210>  3321
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP5__Homo_sapiens__NP_004410

<400>  3321

Met Lys Val Thr Ser Leu Asp Gly Arg Gln Leu Arg Lys Met Leu Arg 
1               5                   10                  15      


Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu 
            20                  25                  30          


Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn 
        35                  40                  45              


Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr 
    50                  55                  60                  


Val Leu Pro Asp Glu Ala Ala Arg Ala Arg Leu Leu Gln Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp 
                85                  90                  95      


Gln Lys Leu Arg Glu Glu Ser Ala Ala Arg Val Val Leu Thr Ser Leu 
            100                 105                 110         


Leu Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly 
        115                 120                 125             


Tyr Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys 
    130                 135                 140                 


Pro Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln 
145                 150                 155                 160 


Cys Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln 
                165                 170                 175     


Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr 
            180                 185                 190         


His Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu 
        195                 200                 205             


Leu Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Ala Thr His Leu His 
    210                 215                 220                 


Tyr Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser 
225                 230                 235                 240 


His Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly 
                245                 250                 255     


Gly Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr 
            260                 265                 270         


Ile Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu 
        275                 280                 285             


Ala Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe 
    290                 295                 300                 


Gly Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser 
305                 310                 315                 320 


Thr Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser 
                325                 330                 335     


Ser Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala 
            340                 345                 350         


Tyr Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser 
        355                 360                 365             


Thr Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Thr Ser Cys 
    370                 375                 380                 


<210>  3322
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP6__Homo_sapiens__NP_001937

<400>  3322

Met Ile Asp Thr Leu Arg Pro Val Pro Phe Ala Ser Glu Met Ala Ile 
1               5                   10                  15      


Ser Lys Thr Val Ala Trp Leu Asn Glu Gln Leu Glu Leu Gly Asn Glu 
            20                  25                  30          


Arg Leu Leu Leu Met Asp Cys Arg Pro Gln Glu Leu Tyr Glu Ser Ser 
        35                  40                  45              


His Ile Glu Ser Ala Ile Asn Val Ala Ile Pro Gly Ile Met Leu Arg 
    50                  55                  60                  


Arg Leu Gln Lys Gly Asn Leu Pro Val Arg Ala Leu Phe Thr Arg Gly 
65                  70                  75                  80  


Glu Asp Arg Asp Arg Phe Thr Arg Arg Cys Gly Thr Asp Thr Val Val 
                85                  90                  95      


Leu Tyr Asp Glu Ser Ser Ser Asp Trp Asn Glu Asn Thr Gly Gly Glu 
            100                 105                 110         


Ser Val Leu Gly Leu Leu Leu Lys Lys Leu Lys Asp Glu Gly Cys Arg 
        115                 120                 125             


Ala Phe Tyr Leu Glu Gly Gly Phe Ser Lys Phe Gln Ala Glu Phe Ser 
    130                 135                 140                 


Leu His Cys Glu Thr Asn Leu Asp Gly Ser Cys Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Pro Leu Pro Val Leu Gly Leu Gly Gly Leu Arg Ile Ser Ser Asp Ser 
                165                 170                 175     


Ser Ser Asp Ile Glu Ser Asp Leu Asp Arg Asp Pro Asn Ser Ala Thr 
            180                 185                 190         


Asp Ser Asp Gly Ser Pro Leu Ser Asn Ser Gln Pro Ser Phe Pro Val 
        195                 200                 205             


Glu Ile Leu Pro Phe Leu Tyr Leu Gly Cys Ala Lys Asp Ser Thr Asn 
    210                 215                 220                 


Leu Asp Val Leu Glu Glu Phe Gly Ile Lys Tyr Ile Leu Asn Val Thr 
225                 230                 235                 240 


Pro Asn Leu Pro Asn Leu Phe Glu Asn Ala Gly Glu Phe Lys Tyr Lys 
                245                 250                 255     


Gln Ile Pro Ile Ser Asp His Trp Ser Gln Asn Leu Ser Gln Phe Phe 
            260                 265                 270         


Pro Glu Ala Ile Ser Phe Ile Asp Glu Ala Arg Gly Lys Asn Cys Gly 
        275                 280                 285             


Val Leu Val His Cys Leu Ala Gly Ile Ser Arg Ser Val Thr Val Thr 
    290                 295                 300                 


Val Ala Tyr Leu Met Gln Lys Leu Asn Leu Ser Met Asn Asp Ala Tyr 
305                 310                 315                 320 


Asp Ile Val Lys Met Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe 
                325                 330                 335     


Met Gly Gln Leu Leu Asp Phe Glu Arg Thr Leu Gly Leu Ser Ser Pro 
            340                 345                 350         


Cys Asp Asn Arg Val Pro Ala Gln Gln Leu Tyr Phe Thr Thr Pro Ser 
        355                 360                 365             


Asn Gln Asn Val Tyr Gln Val Asp Ser Leu Gln Ser Thr 
    370                 375                 380     


<210>  3323
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP7__Homo_sapiens__NP_001938

<400>  3323

Met Lys Asn Gln Leu Arg Gly Pro Pro Ala Arg Ala His Met Ser Thr 
1               5                   10                  15      


Ser Gly Ala Ala Ala Ala Gly Gly Thr Arg Ala Gly Ser Glu Pro Gly 
            20                  25                  30          


Ala Gly Ser Gly Ser Gly Ala Gly Thr Gly Ala Gly Ala Ala Thr Gly 
        35                  40                  45              


Ala Gly Ala Met Pro Cys Lys Ser Ala Glu Trp Leu Gln Glu Glu Leu 
    50                  55                  60                  


Glu Ala Arg Gly Gly Ala Ser Leu Leu Leu Leu Asp Cys Arg Pro His 
65                  70                  75                  80  


Glu Leu Phe Glu Ser Ser His Ile Glu Thr Ala Ile Asn Leu Ala Ile 
                85                  90                  95      


Pro Gly Leu Met Leu Arg Arg Leu Arg Lys Gly Asn Leu Pro Ile Arg 
            100                 105                 110         


Ser Ile Ile Pro Asn His Ala Asp Lys Glu Arg Phe Ala Thr Arg Cys 
        115                 120                 125             


Lys Ala Ala Thr Val Leu Leu Tyr Asp Glu Ala Thr Ala Glu Trp Gln 
    130                 135                 140                 


Pro Glu Pro Gly Ala Pro Ala Ser Val Leu Gly Leu Leu Leu Gln Lys 
145                 150                 155                 160 


Leu Arg Asp Asp Gly Cys Gln Ala Tyr Tyr Leu Gln Gly Gly Phe Asn 
                165                 170                 175     


Lys Phe Gln Thr Glu Tyr Ser Glu His Cys Glu Thr Asn Val Asp Ser 
            180                 185                 190         


Ser Ser Ser Pro Ser Ser Ser Pro Pro Thr Ser Val Leu Gly Leu Gly 
        195                 200                 205             


Gly Leu Arg Ile Ser Ser Asp Cys Ser Asp Gly Glu Ser Asp Arg Glu 
    210                 215                 220                 


Leu Pro Ser Ser Ala Thr Glu Ser Asp Gly Ser Pro Val Pro Ser Ser 
225                 230                 235                 240 


Gln Pro Ala Phe Pro Val Gln Ile Leu Pro Tyr Leu Tyr Leu Gly Cys 
                245                 250                 255     


Ala Lys Asp Ser Thr Asn Leu Asp Val Leu Gly Lys Tyr Gly Ile Lys 
            260                 265                 270         


Tyr Ile Leu Asn Val Thr Pro Asn Leu Pro Asn Ala Phe Glu His Gly 
        275                 280                 285             


Gly Glu Phe Thr Tyr Lys Gln Ile Pro Ile Ser Asp His Trp Ser Gln 
    290                 295                 300                 


Asn Leu Ser Gln Phe Phe Pro Glu Ala Ile Ser Phe Ile Asp Glu Ala 
305                 310                 315                 320 


Arg Ser Lys Lys Cys Gly Val Leu Val His Cys Leu Ala Gly Ile Ser 
                325                 330                 335     


Arg Ser Val Thr Val Thr Val Ala Tyr Leu Met Gln Lys Met Asn Leu 
            340                 345                 350         


Ser Leu Asn Asp Ala Tyr Asp Phe Val Lys Arg Lys Lys Ser Asn Ile 
        355                 360                 365             


Ser Pro Asn Phe Asn Phe Met Gly Gln Leu Leu Asp Phe Glu Arg Thr 
    370                 375                 380                 


Leu Gly Leu Ser Ser Pro Cys Asp Asn His Ala Ser Ser Glu Gln Leu 
385                 390                 395                 400 


Tyr Phe Ser Thr Pro Thr Asn His Asn Leu Phe Pro Leu Asn Thr Leu 
                405                 410                 415     


Glu Ser Thr 
            


<210>  3324
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP8__Homo_sapiens__XP_011518235

<400>  3324

Met Ala Gly Asp Arg Leu Pro Arg Lys Val Met Asp Ala Lys Lys Leu 
1               5                   10                  15      


Ala Ser Leu Leu Arg Gly Gly Pro Gly Gly Pro Leu Val Ile Asp Ser 
            20                  25                  30          


Arg Ser Phe Val Glu Tyr Asn Ser Trp His Val Leu Ser Ser Val Asn 
        35                  40                  45              


Ile Cys Cys Ser Lys Leu Val Lys Arg Arg Leu Gln Gln Gly Lys Val 
    50                  55                  60                  


Thr Ile Ala Glu Leu Ile Gln Pro Ala Ala Arg Ser Gln Val Glu Ala 
65                  70                  75                  80  


Thr Glu Pro Gln Asp Val Val Val Tyr Asp Gln Ser Thr Arg Asp Ala 
                85                  90                  95      


Ser Val Leu Ala Ala Asp Ser Phe Leu Ser Ile Leu Leu Ser Lys Leu 
            100                 105                 110         


Asp Gly Cys Phe Asp Ser Val Ala Ile Leu Thr Gly Gly Phe Ala Thr 
        115                 120                 125             


Phe Ser Ser Cys Phe Pro Gly Leu Cys Glu Gly Lys Pro Ala Ala Leu 
    130                 135                 140                 


Leu Pro Met Ser Leu Ser Gln Pro Cys Leu Pro Val Pro Ser Val Gly 
145                 150                 155                 160 


Leu Thr Arg Ile Leu Pro His Leu Tyr Leu Gly Ser Gln Lys Asp Val 
                165                 170                 175     


Leu Asn Lys Asp Leu Met Thr Gln Asn Gly Ile Ser Tyr Val Leu Asn 
            180                 185                 190         


Ala Ser Asn Ser Cys Pro Lys Pro Asp Phe Ile Cys Glu Ser Arg Phe 
        195                 200                 205             


Met Arg Val Pro Ile Asn Asp Asn Tyr Cys Glu Lys Leu Leu Pro Trp 
    210                 215                 220                 


Leu Asp Lys Ser Ile Glu Phe Ile Asp Lys Ala Lys Leu Ser Ser Cys 
225                 230                 235                 240 


Gln Val Ile Val His Cys Leu Ala Gly Ile Ser Arg Ser Ala Thr Ile 
                245                 250                 255     


Ala Ile Ala Tyr Ile Met Lys Thr Met Gly Met Ser Ser Asp Asp Ala 
            260                 265                 270         


Tyr Arg Phe Val Lys Asp Arg Arg Pro Ser Ile Ser Pro Asn Phe Asn 
        275                 280                 285             


Phe Leu Gly Gln Leu Leu Glu Tyr Glu Arg Ser Leu Lys Leu Leu Ala 
    290                 295                 300                 


Ala Leu Gln Gly Asp Pro Gly Thr Pro Ser Gly Thr Pro Glu Pro Pro 
305                 310                 315                 320 


Pro Ser Pro Ala Ala Gly Ala Pro Leu Pro Arg Leu Pro Pro Pro Thr 
                325                 330                 335     


Ser Glu Ser Ala Ala Thr Gly Asn Ala Ala Ala Arg Glu Gly Gly Leu 
            340                 345                 350         


Ser Ala Gly Gly Glu Pro Pro Ala Pro Pro Thr Pro Pro Ala Thr Ser 
        355                 360                 365             


Ala Leu Gln Gln Gly Leu Arg Gly Leu His Leu Ser Ser Asp Arg Leu 
    370                 375                 380                 


Gln Asp Thr Asn Arg Leu Lys Arg Ser Phe Ser Leu Asp Ile Lys Ser 
385                 390                 395                 400 


Ala Tyr Ala Pro Ser Arg Arg Pro Asp Gly Pro Gly Pro Pro Asp Pro 
                405                 410                 415     


Gly Glu Ala Pro Lys Leu Cys Lys Leu Asp Ser Pro Ser Gly Ala Ala 
            420                 425                 430         


Leu Gly Leu Ser Ser Pro Ser Pro Asp Ser Pro Asp Ala Ala Pro Glu 
        435                 440                 445             


Ala Arg Pro Arg Pro Arg Arg Arg Pro Arg Pro Pro Ala Gly Ser Pro 
    450                 455                 460                 


Ala Arg Ser Pro Ala His Ser Leu Gly Leu Asn Phe Gly Asp Ala Ala 
465                 470                 475                 480 


Arg Gln Thr Pro Arg His Gly Leu Ser Ala Leu Ser Ala Pro Gly Leu 
                485                 490                 495     


Pro Gly Pro Gly Gln Pro Ala Gly Pro Gly Ala Trp Ala Pro Pro Leu 
            500                 505                 510         


Asp Ser Pro Gly Thr Pro Ser Pro Asp Gly Pro Trp Cys Phe Ser Pro 
        515                 520                 525             


Glu Gly Ala Gln Gly Ala Gly Gly Val Leu Phe Ala Pro Phe Gly Arg 
    530                 535                 540                 


Ala Gly Ala Pro Gly Pro Gly Gly Gly Ser Asp Leu Arg Arg Arg Glu 
545                 550                 555                 560 


Ala Ala Arg Ala Glu Pro Arg Asp Ala Arg Thr Gly Trp Pro Glu Glu 
                565                 570                 575     


Pro Ala Pro Glu Thr Gln Phe Lys Arg Arg Ser Cys Gln Met Glu Phe 
            580                 585                 590         


Glu Glu Gly Met Val Glu Gly Arg Ala Arg Gly Glu Glu Leu Ala Ala 
        595                 600                 605             


Leu Gly Lys Gln Ala Ser Phe Ser Gly Ser Val Glu Val Ile Glu Val 
    610                 615                 620                 


Ser 
625 


<210>  3325
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUSP9__Homo_sapiens__XP_011529425

<400>  3325

Met Glu Ala Ala Gln Val Gly Pro Lys Gly Arg Gln Leu Pro Gly Lys 
1               5                   10                  15      


His Val Val Ala Pro Val Val Gln Arg Val Gly Ser Arg Ser Pro Met 
            20                  25                  30          


Glu Gly Leu Gly Arg Ser Cys Leu Trp Leu Arg Arg Glu Leu Ser Pro 
        35                  40                  45              


Pro Arg Pro Arg Leu Leu Leu Leu Asp Cys Arg Ser Arg Glu Leu Tyr 
    50                  55                  60                  


Glu Ser Ala Arg Ile Gly Gly Ala Leu Ser Val Ala Leu Pro Ala Leu 
65                  70                  75                  80  


Leu Leu Arg Arg Leu Arg Arg Gly Ser Leu Ser Val Arg Ala Leu Leu 
                85                  90                  95      


Pro Gly Pro Pro Leu Gln Pro Pro Pro Pro Ala Pro Val Leu Leu Tyr 
            100                 105                 110         


Asp Gln Gly Gly Gly Arg Arg Arg Arg Gly Glu Ala Glu Ala Glu Ala 
        115                 120                 125             


Glu Glu Trp Glu Ala Glu Ser Val Leu Gly Thr Leu Leu Gln Lys Leu 
    130                 135                 140                 


Arg Glu Glu Gly Tyr Leu Ala Tyr Tyr Leu Gln Gly Gly Phe Ser Arg 
145                 150                 155                 160 


Phe Gln Ala Glu Cys Pro His Leu Cys Glu Thr Ser Leu Ala Gly Arg 
                165                 170                 175     


Ala Gly Ser Ser Met Ala Pro Val Pro Gly Pro Val Pro Val Val Gly 
            180                 185                 190         


Leu Gly Ser Leu Cys Leu Gly Ser Asp Cys Ser Asp Ala Glu Ser Glu 
        195                 200                 205             


Ala Asp Arg Asp Ser Met Ser Cys Gly Leu Asp Ser Glu Gly Ala Thr 
    210                 215                 220                 


Pro Pro Pro Val Gly Leu Arg Ala Ser Phe Pro Val Gln Ile Leu Pro 
225                 230                 235                 240 


Asn Leu Tyr Leu Gly Ser Ala Arg Asp Ser Ala Asn Leu Glu Ser Leu 
                245                 250                 255     


Ala Lys Leu Gly Ile Arg Tyr Ile Leu Asn Val Thr Pro Asn Leu Pro 
            260                 265                 270         


Asn Phe Phe Glu Lys Asn Gly Asp Phe His Tyr Lys Gln Ile Pro Ile 
        275                 280                 285             


Ser Asp His Trp Ser Gln Asn Leu Ser Arg Phe Phe Pro Glu Ala Ile 
    290                 295                 300                 


Glu Phe Ile Asp Glu Ala Leu Ser Gln Asn Cys Gly Val Leu Val His 
305                 310                 315                 320 


Cys Leu Ala Gly Val Ser Arg Ser Val Thr Val Thr Val Ala Tyr Leu 
                325                 330                 335     


Met Gln Lys Leu His Leu Ser Leu Asn Asp Ala Tyr Asp Leu Val Lys 
            340                 345                 350         


Arg Lys Lys Ser Asn Ile Ser Pro Asn Phe Asn Phe Met Gly Gln Leu 
        355                 360                 365             


Leu Asp Phe Glu Arg Ser Leu Arg Leu Glu Glu Arg His Ser Gln Glu 
    370                 375                 380                 


Gln Gly Ser Gly Gly Gln Ala Ser Ala Ala Ser Asn Pro Pro Ser Phe 
385                 390                 395                 400 


Phe Thr Thr Pro Thr Ser Asp Gly Ala Phe Glu Leu Ala Pro Thr 
                405                 410                 415 


<210>  3326
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUT__Homo_sapiens__NP_001020419

<400>  3326

Met Thr Pro Leu Cys Pro Arg Pro Ala Leu Cys Tyr His Phe Leu Thr 
1               5                   10                  15      


Ser Leu Leu Arg Ser Ala Met Gln Asn Ala Arg Gly Ala Arg Gln Arg 
            20                  25                  30          


Ala Glu Ala Ala Val Leu Ser Gly Pro Gly Pro Pro Leu Gly Arg Ala 
        35                  40                  45              


Ala Gln His Gly Ile Pro Arg Pro Leu Ser Ser Ala Gly Arg Leu Ser 
    50                  55                  60                  


Gln Gly Cys Arg Gly Ala Ser Thr Val Gly Ala Ala Gly Trp Lys Gly 
65                  70                  75                  80  


Glu Leu Pro Lys Ala Gly Gly Ser Pro Ala Pro Gly Pro Glu Thr Pro 
                85                  90                  95      


Ala Ile Ser Pro Ser Lys Arg Ala Arg Pro Ala Glu Val Gly Gly Met 
            100                 105                 110         


Gln Leu Arg Phe Ala Arg Leu Ser Glu His Ala Thr Ala Pro Thr Arg 
        115                 120                 125             


Gly Ser Ala Arg Ala Ala Gly Tyr Asp Leu Tyr Ser Ala Tyr Asp Tyr 
    130                 135                 140                 


Thr Ile Pro Pro Met Glu Lys Ala Val Val Lys Thr Asp Ile Gln Ile 
145                 150                 155                 160 


Ala Leu Pro Ser Gly Cys Tyr Gly Arg Val Ala Pro Arg Ser Gly Leu 
                165                 170                 175     


Ala Ala Lys His Phe Ile Asp Val Gly Ala Gly Val Ile Asp Glu Asp 
            180                 185                 190         


Tyr Arg Gly Asn Val Gly Val Val Leu Phe Asn Phe Gly Lys Glu Lys 
        195                 200                 205             


Phe Glu Val Lys Lys Gly Asp Arg Ile Ala Gln Leu Ile Cys Glu Arg 
    210                 215                 220                 


Ile Phe Tyr Pro Glu Ile Glu Glu Val Gln Ala Leu Asp Asp Thr Glu 
225                 230                 235                 240 


Arg Gly Ser Gly Gly Phe Gly Ser Thr Gly Lys Asn 
                245                 250         


<210>  3327
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DUX4__Homo_sapiens__XP_011529816

<400>  3327

Met Ala Leu Pro Thr Pro Ser Asp Ser Thr Leu Pro Ala Glu Ala Arg 
1               5                   10                  15      


Gly Arg Gly Arg Arg Arg Arg Leu Val Trp Thr Pro Ser Gln Ser Glu 
            20                  25                  30          


Ala Leu Arg Ala Cys Phe Glu Arg Asn Pro Tyr Pro Gly Ile Ala Thr 
        35                  40                  45              


Arg Glu Arg Leu Ala Gln Ala Ile Gly Ile Pro Glu Pro Arg Val Gln 
    50                  55                  60                  


Ile Trp Phe Gln Asn Glu Arg Ser Arg Gln Leu Arg Gln His Arg Arg 
65                  70                  75                  80  


Glu Ser Arg Pro Trp Pro Gly Arg Arg Gly Pro Pro Glu Gly Arg Arg 
                85                  90                  95      


Lys Arg Thr Ala Val Thr Gly Ser Gln Thr Ala Leu Leu Leu Arg Ala 
            100                 105                 110         


Phe Glu Lys Asp Arg Phe Pro Gly Ile Ala Ala Arg Glu Glu Leu Ala 
        115                 120                 125             


Arg Glu Thr Gly Leu Pro Glu Ser Arg Ile Gln Ile Trp Phe Gln Asn 
    130                 135                 140                 


Arg Arg Ala Arg His Pro Gly Gln Gly Gly Arg Ala Pro Ala Gln Val 
145                 150                 155                 160 


<210>  3328
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DVL2__Homo_sapiens__NP_004413

<400>  3328

Met Ala Gly Ser Ser Thr Gly Gly Gly Gly Val Gly Glu Thr Lys Val 
1               5                   10                  15      


Ile Tyr His Leu Asp Glu Glu Glu Thr Pro Tyr Leu Val Lys Ile Pro 
            20                  25                  30          


Val Pro Ala Glu Arg Ile Thr Leu Gly Asp Phe Lys Ser Val Leu Gln 
        35                  40                  45              


Arg Pro Ala Gly Ala Lys Tyr Phe Phe Lys Ser Met Asp Gln Asp Phe 
    50                  55                  60                  


Gly Val Val Lys Glu Glu Ile Ser Asp Asp Asn Ala Arg Leu Pro Cys 
65                  70                  75                  80  


Phe Asn Gly Arg Val Val Ser Trp Leu Val Ser Ser Asp Asn Pro Gln 
                85                  90                  95      


Pro Glu Met Ala Pro Pro Val His Glu Pro Arg Ala Glu Leu Ala Pro 
            100                 105                 110         


Pro Ala Pro Pro Leu Pro Pro Leu Pro Pro Glu Arg Thr Ser Gly Ile 
        115                 120                 125             


Gly Asp Ser Arg Pro Pro Ser Phe His Pro Asn Val Ser Ser Ser His 
    130                 135                 140                 


Glu Asn Leu Glu Pro Glu Thr Glu Thr Glu Ser Val Val Ser Leu Arg 
145                 150                 155                 160 


Arg Glu Arg Pro Arg Arg Arg Asp Ser Ser Glu His Gly Ala Gly Gly 
                165                 170                 175     


His Arg Thr Gly Gly Pro Ser Arg Leu Glu Arg His Leu Ala Gly Tyr 
            180                 185                 190         


Glu Ser Ser Ser Thr Leu Met Thr Ser Glu Leu Glu Ser Thr Ser Leu 
        195                 200                 205             


Gly Asp Ser Asp Glu Glu Asp Thr Met Ser Arg Phe Ser Ser Ser Thr 
    210                 215                 220                 


Glu Gln Ser Ser Ala Ser Arg Leu Leu Lys Arg His Arg Arg Arg Arg 
225                 230                 235                 240 


Lys Gln Arg Pro Pro Arg Leu Glu Arg Thr Ser Ser Phe Ser Ser Val 
                245                 250                 255     


Thr Asp Ser Thr Met Ser Leu Asn Ile Ile Thr Val Thr Leu Asn Met 
            260                 265                 270         


Glu Lys Tyr Asn Phe Leu Gly Ile Ser Ile Val Gly Gln Ser Asn Glu 
        275                 280                 285             


Arg Gly Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly Gly Ala 
    290                 295                 300                 


Val Ala Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu Gln Val 
305                 310                 315                 320 


Asn Asp Met Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val Arg Val 
                325                 330                 335     


Leu Arg Asp Ile Val His Lys Pro Gly Pro Ile Val Leu Thr Val Ala 
            340                 345                 350         


Lys Cys Trp Asp Pro Ser Pro Gln Ala Tyr Phe Thr Leu Pro Arg Asn 
        355                 360                 365             


Glu Pro Ile Gln Pro Ile Asp Pro Ala Ala Trp Val Ser His Ser Ala 
    370                 375                 380                 


Ala Leu Thr Gly Thr Phe Pro Ala Tyr Pro Gly Ser Ser Ser Met Ser 
385                 390                 395                 400 


Thr Ile Thr Ser Gly Ser Ser Leu Pro Asp Gly Cys Glu Gly Arg Gly 
                405                 410                 415     


Leu Ser Val His Thr Asp Met Ala Ser Val Thr Lys Ala Met Ala Ala 
            420                 425                 430         


Pro Glu Ser Gly Leu Glu Val Arg Asp Arg Met Trp Leu Lys Ile Thr 
        435                 440                 445             


Ile Pro Asn Ala Phe Leu Gly Ser Asp Val Val Asp Trp Leu Tyr His 
    450                 455                 460                 


His Val Glu Gly Phe Pro Glu Arg Arg Glu Ala Arg Lys Tyr Ala Ser 
465                 470                 475                 480 


Gly Leu Leu Lys Ala Gly Leu Ile Arg His Thr Val Asn Lys Ile Thr 
                485                 490                 495     


Phe Ser Glu Gln Cys Tyr Tyr Val Phe Gly Asp Leu Ser Gly Gly Cys 
            500                 505                 510         


Glu Ser Tyr Leu Val Asn Leu Ser Leu Asn Asp Asn Asp Gly Ser Ser 
        515                 520                 525             


Gly Ala Ser Asp Gln Asp Thr Leu Ala Pro Leu Pro Gly Ala Thr Pro 
    530                 535                 540                 


Trp Pro Leu Leu Pro Thr Phe Ser Tyr Gln Tyr Pro Ala Pro His Pro 
545                 550                 555                 560 


Tyr Ser Pro Gln Pro Pro Pro Tyr His Glu Leu Ser Ser Tyr Thr Tyr 
                565                 570                 575     


Gly Gly Gly Ser Ala Ser Ser Gln His Ser Glu Gly Ser Arg Ser Ser 
            580                 585                 590         


Gly Ser Thr Arg Ser Asp Gly Gly Ala Gly Arg Thr Gly Arg Pro Glu 
        595                 600                 605             


Glu Arg Ala Pro Glu Ser Lys Ser Gly Ser Gly Ser Glu Ser Glu Pro 
    610                 615                 620                 


Ser Ser Arg Gly Gly Ser Leu Arg Arg Gly Gly Glu Ala Ser Gly Thr 
625                 630                 635                 640 


Ser Asp Gly Gly Pro Pro Pro Ser Arg Gly Ser Thr Gly Gly Ala Pro 
                645                 650                 655     


Asn Leu Arg Ala His Pro Gly Leu His Pro Tyr Gly Pro Pro Pro Gly 
            660                 665                 670         


Met Ala Leu Pro Tyr Asn Pro Met Met Val Val Met Met Pro Pro Pro 
        675                 680                 685             


Pro Pro Pro Val Pro Pro Ala Val Gln Pro Pro Gly Ala Pro Pro Val 
    690                 695                 700                 


Arg Asp Leu Gly Ser Val Pro Pro Glu Leu Thr Ala Ser Arg Gln Ser 
705                 710                 715                 720 


Phe His Met Ala Met Gly Asn Pro Ser Glu Phe Phe Val Asp Val Met 
                725                 730                 735     


<210>  3329
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DVL3__Homo_sapiens__NP_004414

<400>  3329

Met Gly Glu Thr Lys Ile Ile Tyr His Leu Asp Gly Gln Glu Thr Pro 
1               5                   10                  15      


Tyr Leu Val Lys Leu Pro Leu Pro Ala Glu Arg Val Thr Leu Ala Asp 
            20                  25                  30          


Phe Lys Gly Val Leu Gln Arg Pro Ser Tyr Lys Phe Phe Phe Lys Ser 
        35                  40                  45              


Met Asp Asp Asp Phe Gly Val Val Lys Glu Glu Ile Ser Asp Asp Asn 
    50                  55                  60                  


Ala Lys Leu Pro Cys Phe Asn Gly Arg Val Val Ser Trp Leu Val Ser 
65                  70                  75                  80  


Ala Glu Gly Ser His Pro Asp Pro Ala Pro Phe Cys Ala Asp Asn Pro 
                85                  90                  95      


Ser Glu Leu Pro Pro Pro Met Glu Arg Thr Gly Gly Ile Gly Asp Ser 
            100                 105                 110         


Arg Pro Pro Ser Phe His Pro His Ala Gly Gly Gly Ser Gln Glu Asn 
        115                 120                 125             


Leu Asp Asn Asp Thr Glu Thr Asp Ser Leu Val Ser Ala Gln Arg Glu 
    130                 135                 140                 


Arg Pro Arg Arg Arg Asp Gly Pro Glu His Ala Thr Arg Leu Asn Gly 
145                 150                 155                 160 


Thr Ala Lys Gly Glu Arg Arg Arg Glu Pro Gly Gly Tyr Asp Ser Ser 
                165                 170                 175     


Ser Thr Leu Met Ser Ser Glu Leu Glu Thr Thr Ser Phe Phe Asp Ser 
            180                 185                 190         


Asp Glu Asp Asp Ser Thr Ser Arg Phe Ser Ser Ser Thr Glu Gln Ser 
        195                 200                 205             


Ser Ala Ser Arg Leu Met Arg Arg His Lys Arg Arg Arg Arg Lys Gln 
    210                 215                 220                 


Lys Val Ser Arg Ile Glu Arg Ser Ser Ser Phe Ser Ser Ile Thr Asp 
225                 230                 235                 240 


Ser Thr Met Ser Leu Asn Ile Ile Thr Val Thr Leu Asn Met Glu Lys 
                245                 250                 255     


Tyr Asn Phe Leu Gly Ile Ser Ile Val Gly Gln Ser Asn Glu Arg Gly 
            260                 265                 270         


Asp Gly Gly Ile Tyr Ile Gly Ser Ile Met Lys Gly Gly Ala Val Ala 
        275                 280                 285             


Ala Asp Gly Arg Ile Glu Pro Gly Asp Met Leu Leu Gln Val Asn Glu 
    290                 295                 300                 


Ile Asn Phe Glu Asn Met Ser Asn Asp Asp Ala Val Arg Val Leu Arg 
305                 310                 315                 320 


Glu Ile Val His Lys Pro Gly Pro Ile Thr Leu Thr Val Ala Lys Cys 
                325                 330                 335     


Trp Asp Pro Ser Pro Arg Gly Cys Phe Thr Leu Pro Arg Ser Glu Pro 
            340                 345                 350         


Ile Arg Pro Ile Asp Pro Ala Ala Trp Val Ser His Thr Ala Ala Met 
        355                 360                 365             


Thr Gly Thr Phe Pro Ala Tyr Gly Met Ser Pro Ser Leu Ser Thr Ile 
    370                 375                 380                 


Thr Ser Thr Ser Ser Ser Ile Thr Ser Ser Ile Pro Asp Thr Glu Arg 
385                 390                 395                 400 


Leu Asp Asp Phe His Leu Ser Ile His Ser Asp Met Ala Ala Ile Val 
                405                 410                 415     


Lys Ala Met Ala Ser Pro Glu Ser Gly Leu Glu Val Arg Asp Arg Met 
            420                 425                 430         


Trp Leu Lys Ile Thr Ile Pro Asn Ala Phe Ile Gly Ser Asp Val Val 
        435                 440                 445             


Asp Trp Leu Tyr His Asn Val Glu Gly Phe Thr Asp Arg Arg Glu Ala 
    450                 455                 460                 


Arg Lys Tyr Ala Ser Asn Leu Leu Lys Ala Gly Phe Ile Arg His Thr 
465                 470                 475                 480 


Val Asn Lys Ile Thr Phe Ser Glu Gln Cys Tyr Tyr Ile Phe Gly Asp 
                485                 490                 495     


Leu Cys Gly Asn Met Ala Asn Leu Ser Leu His Asp His Asp Gly Ser 
            500                 505                 510         


Ser Gly Ala Ser Asp Gln Asp Thr Leu Ala Pro Leu Pro His Pro Gly 
        515                 520                 525             


Ala Ala Pro Trp Pro Met Ala Phe Pro Tyr Gln Tyr Pro Pro Pro Pro 
    530                 535                 540                 


His Pro Tyr Asn Pro His Pro Gly Phe Pro Glu Leu Gly Tyr Ser Tyr 
545                 550                 555                 560 


Gly Gly Gly Ser Ala Ser Ser Gln His Ser Glu Gly Ser Arg Ser Ser 
                565                 570                 575     


Gly Ser Asn Arg Ser Gly Ser Asp Arg Arg Lys Glu Lys Asp Pro Lys 
            580                 585                 590         


Ala Gly Asp Ser Lys Ser Gly Gly Ser Gly Ser Glu Ser Asp His Thr 
        595                 600                 605             


Thr Arg Ser Ser Leu Arg Gly Pro Arg Glu Arg Ala Pro Ser Glu Arg 
    610                 615                 620                 


Ser Gly Pro Ala Ala Ser Glu His Ser His Arg Ser His His Ser Leu 
625                 630                 635                 640 


Ala Ser Ser Leu Arg Ser His His Thr His Pro Ser Tyr Gly Pro Pro 
                645                 650                 655     


Gly Val Pro Pro Leu Tyr Gly Pro Pro Met Leu Met Met Pro Pro Pro 
            660                 665                 670         


Pro Ala Ala Met Gly Pro Pro Gly Ala Pro Pro Gly Arg Asp Leu Ala 
        675                 680                 685             


Ser Val Pro Pro Glu Leu Thr Ala Ser Arg Gln Ser Phe Arg Met Ala 
    690                 695                 700                 


Met Gly Asn Pro Ser Glu Phe Phe Val Asp Val Met 
705                 710                 715     


<210>  3330
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DXO__Homo_sapiens__XP_006715068

<400>  3330

Met Asp Pro Arg Gly Thr Lys Arg Gly Ala Glu Lys Thr Glu Val Ala 
1               5                   10                  15      


Glu Pro Arg Asn Lys Leu Pro Arg Pro Ala Pro Ser Leu Pro Thr Asp 
            20                  25                  30          


Pro Ala Leu Tyr Ser Gly Pro Phe Pro Phe Tyr Arg Arg Pro Ser Glu 
        35                  40                  45              


Leu Gly Cys Phe Ser Leu Asp Ala Gln Arg Gln Tyr His Gly Asp Ala 
    50                  55                  60                  


Arg Ala Leu Arg Tyr Tyr Ser Pro Pro Pro Thr Asn Gly Pro Gly Pro 
65                  70                  75                  80  


Asn Phe Asp Leu Arg Asp Gly Tyr Pro Asp Arg Tyr Gln Pro Arg Asp 
                85                  90                  95      


Glu Glu Val Gln Glu Arg Leu Asp His Leu Leu Cys Trp Leu Leu Glu 
            100                 105                 110         


His Arg Gly Arg Leu Glu Gly Gly Pro Gly Trp Leu Ala Glu Ala Ile 
        115                 120                 125             


Val Thr Trp Arg Gly His Leu Thr Lys Leu Leu Thr Thr Pro Tyr Glu 
    130                 135                 140                 


Arg Gln Glu Gly Trp Gln Leu Ala Ala Ser Arg Phe Gln Gly Thr Leu 
145                 150                 155                 160 


Tyr Leu Ser Glu Val Glu Thr Pro Asn Ala Arg Ala Gln Arg Leu Ala 
                165                 170                 175     


Arg Pro Pro Leu Leu Arg Glu Leu Met Tyr Met Gly Tyr Lys Phe Glu 
            180                 185                 190         


Gln Tyr Met Cys Ala Asp Lys Pro Gly Ser Ser Pro Asp Pro Ser Gly 
        195                 200                 205             


Glu Val Asn Thr Asn Val Ala Phe Cys Ser Val Leu Arg Ser Arg Leu 
    210                 215                 220                 


Gly Ser His Pro Leu Leu Phe Ser Gly Glu Val Asp Cys Thr Asp Pro 
225                 230                 235                 240 


Gln Ala Pro Ser Thr Gln Pro Pro Thr Cys Tyr Val Glu Leu Lys Thr 
                245                 250                 255     


Ser Lys Glu Met His Ser Pro Gly Gln Trp Arg Ser Phe Tyr Arg His 
            260                 265                 270         


Lys Leu Leu Lys Trp Trp Ala Gln Ser Phe Leu Pro Gly Val Pro Asn 
        275                 280                 285             


Val Val Ala Gly Phe Arg Asn Pro Asp Gly Phe Val Ser Ser Leu Lys 
    290                 295                 300                 


Thr Phe Pro Thr Met Lys Met Phe Glu Tyr Val Arg Asn Asp Arg Asp 
305                 310                 315                 320 


Gly Trp Asn Pro Ser Val Cys Met Asn Phe Cys Ala Ala Phe Leu Ser 
                325                 330                 335     


Phe Ala Gln Ser Thr Val Val Gln Asp Asp Pro Arg Leu Val His Leu 
            340                 345                 350         


Phe Ser Trp Glu Pro Gly Gly Pro Val Thr Val Ser Val His Gln Asp 
        355                 360                 365             


Ala Pro Tyr Ala Phe Leu Pro Ile Trp Tyr Val Glu Ala Met Thr Gln 
    370                 375                 380                 


Asp Leu Pro Ser Pro Pro Lys Thr Pro Ser Pro Lys 
385                 390                 395     


<210>  3331
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYM__Homo_sapiens__NP_060123

<400>  3331

Met Gly Ser Asn Ser Ser Arg Ile Gly Asp Leu Pro Lys Asn Glu Tyr 
1               5                   10                  15      


Leu Lys Lys Leu Ser Gly Thr Glu Ser Ile Ser Glu Asn Asp Pro Phe 
            20                  25                  30          


Trp Asn Gln Leu Leu Ser Phe Ser Phe Pro Ala Pro Thr Ser Ser Ser 
        35                  40                  45              


Glu Leu Lys Leu Leu Glu Glu Ala Thr Ile Ser Val Cys Arg Ser Leu 
    50                  55                  60                  


Val Glu Asn Asn Pro Arg Thr Gly Asn Leu Gly Ala Leu Ile Lys Val 
65                  70                  75                  80  


Phe Leu Ser Arg Thr Lys Glu Leu Lys Leu Ser Ala Glu Cys Gln Asn 
                85                  90                  95      


His Ile Phe Ile Trp Gln Thr His Asn Ala Leu Phe Ile Ile Cys Cys 
            100                 105                 110         


Leu Leu Lys Val Phe Ile Cys Gln Met Ser Glu Glu Glu Leu Gln Leu 
        115                 120                 125             


His Phe Thr Tyr Glu Glu Lys Ser Pro Gly Asn Tyr Ser Ser Asp Ser 
    130                 135                 140                 


Glu Asp Leu Leu Glu Glu Leu Leu Cys Cys Leu Met Gln Leu Ile Thr 
145                 150                 155                 160 


Asp Ile Pro Leu Leu Asp Ile Thr Tyr Glu Ile Ser Val Glu Ala Ile 
                165                 170                 175     


Ser Thr Met Val Val Phe Leu Ser Cys Gln Leu Phe His Lys Glu Val 
            180                 185                 190         


Leu Arg Gln Ser Ile Ser His Lys Tyr Leu Met Arg Gly Pro Cys Leu 
        195                 200                 205             


Pro Tyr Thr Ser Lys Leu Val Lys Thr Leu Leu Tyr Asn Phe Ile Arg 
    210                 215                 220                 


Gln Glu Lys Pro Pro Pro Pro Gly Ala His Val Phe Pro Gln Gln Ser 
225                 230                 235                 240 


Asp Gly Gly Gly Leu Leu Tyr Gly Leu Ala Ser Gly Val Ala Thr Gly 
                245                 250                 255     


Leu Trp Thr Val Phe Thr Leu Gly Gly Val Gly Ser Lys Ala Ala Ala 
            260                 265                 270         


Ser Pro Glu Leu Ser Ser Pro Leu Ala Asn Gln Ser Leu Leu Leu Leu 
        275                 280                 285             


Leu Val Leu Ala Asn Leu Thr Asp Ala Ser Asp Ala Pro Asn Pro Tyr 
    290                 295                 300                 


Arg Gln Ala Ile Met Ser Phe Lys Asn Thr Gln Asp Ser Ser Pro Phe 
305                 310                 315                 320 


Pro Ser Ser Ile Pro His Ala Phe Gln Ile Asn Phe Asn Ser Leu Tyr 
                325                 330                 335     


Thr Ala Leu Cys Glu Gln Gln Thr Ser Asp Gln Ala Thr Leu Leu Leu 
            340                 345                 350         


Tyr Thr Leu Leu His Gln Asn Ser Asn Ile Arg Thr Tyr Met Leu Ala 
        355                 360                 365             


Arg Thr Asp Met Glu Asn Leu Val Leu Pro Ile Leu Glu Ile Leu Tyr 
    370                 375                 380                 


His Val Glu Glu Arg Asn Ser His His Val Tyr Met Ala Leu Ile Ile 
385                 390                 395                 400 


Leu Leu Ile Leu Thr Glu Asp Asp Gly Phe Asn Arg Ser Ile His Glu 
                405                 410                 415     


Val Ile Leu Lys Asn Ile Thr Trp Tyr Ser Glu Arg Val Leu Thr Glu 
            420                 425                 430         


Ile Ser Leu Gly Ser Leu Leu Ile Leu Val Val Ile Arg Thr Ile Gln 
        435                 440                 445             


Tyr Asn Met Thr Arg Thr Arg Asp Lys Tyr Leu His Thr Asn Cys Leu 
    450                 455                 460                 


Ala Ala Leu Ala Asn Met Ser Ala Gln Phe Arg Ser Leu His Gln Tyr 
465                 470                 475                 480 


Ala Ala Gln Arg Ile Ile Ser Leu Phe Ser Leu Leu Ser Lys Lys His 
                485                 490                 495     


Asn Lys Val Leu Glu Gln Ala Thr Gln Ser Leu Arg Gly Ser Leu Ser 
            500                 505                 510         


Ser Asn Asp Val Pro Leu Pro Asp Tyr Ala Gln Asp Leu Asn Val Ile 
        515                 520                 525             


Glu Glu Val Ile Arg Met Met Leu Glu Ile Ile Asn Ser Cys Leu Thr 
    530                 535                 540                 


Asn Ser Leu His His Asn Pro Asn Leu Val Tyr Ala Leu Leu Tyr Lys 
545                 550                 555                 560 


Arg Asp Leu Phe Glu Gln Phe Arg Thr His Pro Ser Phe Gln Asp Ile 
                565                 570                 575     


Met Gln Asn Ile Asp Leu Val Ile Ser Phe Phe Ser Ser Arg Leu Leu 
            580                 585                 590         


Gln Ala Gly Ala Glu Leu Ser Val Glu Arg Val Leu Glu Ile Ile Lys 
        595                 600                 605             


Gln Gly Val Val Ala Leu Pro Lys Asp Arg Leu Lys Lys Phe Pro Glu 
    610                 615                 620                 


Leu Lys Phe Lys Tyr Val Glu Glu Glu Gln Pro Glu Glu Phe Phe Ile 
625                 630                 635                 640 


Pro Tyr Val Trp Ser Leu Val Tyr Asn Ser Ala Val Gly Leu Tyr Trp 
                645                 650                 655     


Asn Pro Gln Asp Ile Gln Leu Phe Thr Met Asp Ser Asp 
            660                 665                 


<210>  3332
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNAP__Homo_sapiens__NP_775900

<400>  3332

Met Val Ala Asp Ile Lys Gly Asn Glu Gln Ile Glu Lys Tyr Ser Trp 
1               5                   10                  15      


Arg Glu Ala Cys Asp Thr Gly Ser Ser Arg Met Asp Arg Lys His Gly 
            20                  25                  30          


Lys Tyr Ile Leu Asn Val Glu His Ser Glu Asn Gln Pro Pro Ile Thr 
        35                  40                  45              


His Pro Asn Asp Gln Glu Ala His Ser Ser Ile Cys Trp Cys Leu Pro 
    50                  55                  60                  


Ser Asn Asp Ile Thr Ser Asp Val Ser Pro Asn Leu Thr Gly Val Cys 
65                  70                  75                  80  


Val Asn Pro Gly Ile Leu Ala His Ser Arg Cys Leu Gln Ser Glu Ser 
                85                  90                  95      


Cys Asn Thr Gln Val Lys Glu Tyr Cys Arg Asn Asp Trp Ser Met Trp 
            100                 105                 110         


Lys Val Phe Leu Ala Cys Leu Leu Ala Cys Val Ile Met Thr Ala Ile 
        115                 120                 125             


Gly Val Leu Ile Ile Cys Leu Val Asn Asn Lys Gly Ser Ala Asn Ser 
    130                 135                 140                 


Ser Ile Val Ile Gln Leu Ser Thr Asn Asp Gly Glu Cys Val Thr Val 
145                 150                 155                 160 


Lys Pro Gly Thr Pro Ser Pro Ala Cys Pro Pro Thr Met Thr Thr Thr 
                165                 170                 175     


Ser Thr Val Pro Ala Ser Thr Ala Thr Glu Ser Thr Thr Ser Thr Ala 
            180                 185                 190         


Thr Ala Ala Thr Thr Ser Thr Glu Pro Ile Thr Val Ala Pro Thr Asp 
        195                 200                 205             


His Leu 
    210 


<210>  3333
<211>  4646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNC1H1__Homo_sapiens__NP_001367

<400>  3333

Met Ser Glu Pro Gly Gly Gly Gly Gly Glu Asp Gly Ser Ala Gly Leu 
1               5                   10                  15      


Glu Val Ser Ala Val Gln Asn Val Ala Asp Val Ser Val Leu Gln Lys 
            20                  25                  30          


His Leu Arg Lys Leu Val Pro Leu Leu Leu Glu Asp Gly Gly Glu Ala 
        35                  40                  45              


Pro Ala Ala Leu Glu Ala Ala Leu Glu Glu Lys Ser Ala Leu Glu Gln 
    50                  55                  60                  


Met Arg Lys Phe Leu Ser Asp Pro Gln Val His Thr Val Leu Val Glu 
65                  70                  75                  80  


Arg Ser Thr Leu Lys Glu Asp Val Gly Asp Glu Gly Glu Glu Glu Lys 
                85                  90                  95      


Glu Phe Ile Ser Tyr Asn Ile Asn Ile Asp Ile His Tyr Gly Val Lys 
            100                 105                 110         


Ser Asn Ser Leu Ala Phe Ile Lys Arg Thr Pro Val Ile Asp Ala Asp 
        115                 120                 125             


Lys Pro Val Ser Ser Gln Leu Arg Val Leu Thr Leu Ser Glu Asp Ser 
    130                 135                 140                 


Pro Tyr Glu Thr Leu His Ser Phe Ile Ser Asn Ala Val Ala Pro Phe 
145                 150                 155                 160 


Phe Lys Ser Tyr Ile Arg Glu Ser Gly Lys Ala Asp Arg Asp Gly Asp 
                165                 170                 175     


Lys Met Ala Pro Ser Val Glu Lys Lys Ile Ala Glu Leu Glu Met Gly 
            180                 185                 190         


Leu Leu His Leu Gln Gln Asn Ile Glu Ile Pro Glu Ile Ser Leu Pro 
        195                 200                 205             


Ile His Pro Met Ile Thr Asn Val Ala Lys Gln Cys Tyr Glu Arg Gly 
    210                 215                 220                 


Glu Lys Pro Lys Val Thr Asp Phe Gly Asp Lys Val Glu Asp Pro Thr 
225                 230                 235                 240 


Phe Leu Asn Gln Leu Gln Ser Gly Val Asn Arg Trp Ile Arg Glu Ile 
                245                 250                 255     


Gln Lys Val Thr Lys Leu Asp Arg Asp Pro Ala Ser Gly Thr Ala Leu 
            260                 265                 270         


Gln Glu Ile Ser Phe Trp Leu Asn Leu Glu Arg Ala Leu Tyr Arg Ile 
        275                 280                 285             


Gln Glu Lys Arg Glu Ser Pro Glu Val Leu Leu Thr Leu Asp Ile Leu 
    290                 295                 300                 


Lys His Gly Lys Arg Phe His Ala Thr Val Ser Phe Asp Thr Asp Thr 
305                 310                 315                 320 


Gly Leu Lys Gln Ala Leu Glu Thr Val Asn Asp Tyr Asn Pro Leu Met 
                325                 330                 335     


Lys Asp Phe Pro Leu Asn Asp Leu Leu Ser Ala Thr Glu Leu Asp Lys 
            340                 345                 350         


Ile Arg Gln Ala Leu Val Ala Ile Phe Thr His Leu Arg Lys Ile Arg 
        355                 360                 365             


Asn Thr Lys Tyr Pro Ile Gln Arg Ala Leu Arg Leu Val Glu Ala Ile 
    370                 375                 380                 


Ser Arg Asp Leu Ser Ser Gln Leu Leu Lys Val Leu Gly Thr Arg Lys 
385                 390                 395                 400 


Leu Met His Val Ala Tyr Glu Glu Phe Glu Lys Val Met Val Ala Cys 
                405                 410                 415     


Phe Glu Val Phe Gln Thr Trp Asp Asp Glu Tyr Glu Lys Leu Gln Val 
            420                 425                 430         


Leu Leu Arg Asp Ile Val Lys Arg Lys Arg Glu Glu Asn Leu Lys Met 
        435                 440                 445             


Val Trp Arg Ile Asn Pro Ala His Arg Lys Leu Gln Ala Arg Leu Asp 
    450                 455                 460                 


Gln Met Arg Lys Phe Arg Arg Gln His Glu Gln Leu Arg Ala Val Ile 
465                 470                 475                 480 


Val Arg Val Leu Arg Pro Gln Val Thr Ala Val Ala Gln Gln Asn Gln 
                485                 490                 495     


Gly Glu Val Pro Glu Pro Gln Asp Met Lys Val Ala Glu Val Leu Phe 
            500                 505                 510         


Asp Ala Ala Asp Ala Asn Ala Ile Glu Glu Val Asn Leu Ala Tyr Glu 
        515                 520                 525             


Asn Val Lys Glu Val Asp Gly Leu Asp Val Ser Lys Glu Gly Thr Glu 
    530                 535                 540                 


Ala Trp Glu Ala Ala Met Lys Arg Tyr Asp Glu Arg Ile Asp Arg Val 
545                 550                 555                 560 


Glu Thr Arg Ile Thr Ala Arg Leu Arg Asp Gln Leu Gly Thr Ala Lys 
                565                 570                 575     


Asn Ala Asn Glu Met Phe Arg Ile Phe Ser Arg Phe Asn Ala Leu Phe 
            580                 585                 590         


Val Arg Pro His Ile Arg Gly Ala Ile Arg Glu Tyr Gln Thr Gln Leu 
        595                 600                 605             


Ile Gln Arg Val Lys Asp Asp Ile Glu Ser Leu His Asp Lys Phe Lys 
    610                 615                 620                 


Val Gln Tyr Pro Gln Ser Gln Ala Cys Lys Met Ser His Val Arg Asp 
625                 630                 635                 640 


Leu Pro Pro Val Ser Gly Ser Ile Ile Trp Ala Lys Gln Ile Asp Arg 
                645                 650                 655     


Gln Leu Thr Ala Tyr Met Lys Arg Val Glu Asp Val Leu Gly Lys Gly 
            660                 665                 670         


Trp Glu Asn His Val Glu Gly Gln Lys Leu Lys Gln Asp Gly Asp Ser 
        675                 680                 685             


Phe Arg Met Lys Leu Asn Thr Gln Glu Ile Phe Asp Asp Trp Ala Arg 
    690                 695                 700                 


Lys Val Gln Gln Arg Asn Leu Gly Val Ser Gly Arg Ile Phe Thr Ile 
705                 710                 715                 720 


Glu Ser Thr Arg Val Arg Gly Arg Thr Gly Asn Val Leu Lys Leu Lys 
                725                 730                 735     


Val Asn Phe Leu Pro Glu Ile Ile Thr Leu Ser Lys Glu Val Arg Asn 
            740                 745                 750         


Leu Lys Trp Leu Gly Phe Arg Val Pro Leu Ala Ile Val Asn Lys Ala 
        755                 760                 765             


His Gln Ala Asn Gln Leu Tyr Pro Phe Ala Ile Ser Leu Ile Glu Ser 
    770                 775                 780                 


Val Arg Thr Tyr Glu Arg Thr Cys Glu Lys Val Glu Glu Arg Asn Thr 
785                 790                 795                 800 


Ile Ser Leu Leu Val Ala Gly Leu Lys Lys Glu Val Gln Ala Leu Ile 
                805                 810                 815     


Ala Glu Gly Ile Ala Leu Val Trp Glu Ser Tyr Lys Leu Asp Pro Tyr 
            820                 825                 830         


Val Gln Arg Leu Ala Glu Thr Val Phe Asn Phe Gln Glu Lys Val Asp 
        835                 840                 845             


Asp Leu Leu Ile Ile Glu Glu Lys Ile Asp Leu Glu Val Arg Ser Leu 
    850                 855                 860                 


Glu Thr Cys Met Tyr Asp His Lys Thr Phe Ser Glu Ile Leu Asn Arg 
865                 870                 875                 880 


Val Gln Lys Ala Val Asp Asp Leu Asn Leu His Ser Tyr Ser Asn Leu 
                885                 890                 895     


Pro Ile Trp Val Asn Lys Leu Asp Met Glu Ile Glu Arg Ile Leu Gly 
            900                 905                 910         


Val Arg Leu Gln Ala Gly Leu Arg Ala Trp Thr Gln Val Leu Leu Gly 
        915                 920                 925             


Gln Ala Glu Asp Lys Ala Glu Val Asp Met Asp Thr Asp Ala Pro Gln 
    930                 935                 940                 


Val Ser His Lys Pro Gly Gly Glu Pro Lys Ile Lys Asn Val Val His 
945                 950                 955                 960 


Glu Leu Arg Ile Thr Asn Gln Val Ile Tyr Leu Asn Pro Pro Ile Glu 
                965                 970                 975     


Glu Cys Arg Tyr Lys Leu Tyr Gln Glu Met Phe Ala Trp Lys Met Val 
            980                 985                 990         


Val Leu Ser Leu Pro Arg Ile Gln  Ser Gln Arg Tyr Gln  Val Gly Val 
        995                 1000                 1005             


His Tyr  Glu Leu Thr Glu Glu  Glu Lys Phe Tyr Arg  Asn Ala Leu 
    1010                 1015                 1020             


Thr Arg  Met Pro Asp Gly Pro  Val Ala Leu Glu Glu  Ser Tyr Ser 
    1025                 1030                 1035             


Ala Val  Met Gly Ile Val Ser  Glu Val Glu Gln Tyr  Val Lys Val 
    1040                 1045                 1050             


Trp Leu  Gln Tyr Gln Cys Leu  Trp Asp Met Gln Ala  Glu Asn Ile 
    1055                 1060                 1065             


Tyr Asn  Arg Leu Gly Glu Asp  Leu Asn Lys Trp Gln  Ala Leu Leu 
    1070                 1075                 1080             


Val Gln  Ile Arg Lys Ala Arg  Gly Thr Phe Asp Asn  Ala Glu Thr 
    1085                 1090                 1095             


Lys Lys  Glu Phe Gly Pro Val  Val Ile Asp Tyr Gly  Lys Val Gln 
    1100                 1105                 1110             


Ser Lys  Val Asn Leu Lys Tyr  Asp Ser Trp His Lys  Glu Val Leu 
    1115                 1120                 1125             


Ser Lys  Phe Gly Gln Met Leu  Gly Ser Asn Met Thr  Glu Phe His 
    1130                 1135                 1140             


Ser Gln  Ile Ser Lys Ser Arg  Gln Glu Leu Glu Gln  His Ser Val 
    1145                 1150                 1155             


Asp Thr  Ala Ser Thr Ser Asp  Ala Val Thr Phe Ile  Thr Tyr Val 
    1160                 1165                 1170             


Gln Ser  Leu Lys Arg Lys Ile  Lys Gln Phe Glu Lys  Gln Val Glu 
    1175                 1180                 1185             


Leu Tyr  Arg Asn Gly Gln Arg  Leu Leu Glu Lys Gln  Arg Phe Gln 
    1190                 1195                 1200             


Phe Pro  Pro Ser Trp Leu Tyr  Ile Asp Asn Ile Glu  Gly Glu Trp 
    1205                 1210                 1215             


Gly Ala  Phe Asn Asp Ile Met  Arg Arg Lys Asp Ser  Ala Ile Gln 
    1220                 1225                 1230             


Gln Gln  Val Ala Asn Leu Gln  Met Lys Ile Val Gln  Glu Asp Arg 
    1235                 1240                 1245             


Ala Val  Glu Ser Arg Thr Thr  Asp Leu Leu Thr Asp  Trp Glu Lys 
    1250                 1255                 1260             


Thr Lys  Pro Val Thr Gly Asn  Leu Arg Pro Glu Glu  Ala Leu Gln 
    1265                 1270                 1275             


Ala Leu  Thr Ile Tyr Glu Gly  Lys Phe Gly Arg Leu  Lys Asp Asp 
    1280                 1285                 1290             


Arg Glu  Lys Cys Ala Lys Ala  Lys Glu Ala Leu Glu  Leu Thr Asp 
    1295                 1300                 1305             


Thr Gly  Leu Leu Ser Gly Ser  Glu Glu Arg Val Gln  Val Ala Leu 
    1310                 1315                 1320             


Glu Glu  Leu Gln Asp Leu Lys  Gly Val Trp Ser Glu  Leu Ser Lys 
    1325                 1330                 1335             


Val Trp  Glu Gln Ile Asp Gln  Met Lys Glu Gln Pro  Trp Val Ser 
    1340                 1345                 1350             


Val Gln  Pro Arg Lys Leu Arg  Gln Asn Leu Asp Ala  Leu Leu Asn 
    1355                 1360                 1365             


Gln Leu  Lys Ser Phe Pro Ala  Arg Leu Arg Gln Tyr  Ala Ser Tyr 
    1370                 1375                 1380             


Glu Phe  Val Gln Arg Leu Leu  Lys Gly Tyr Met Lys  Ile Asn Met 
    1385                 1390                 1395             


Leu Val  Ile Glu Leu Lys Ser  Glu Ala Leu Lys Asp  Arg His Trp 
    1400                 1405                 1410             


Lys Gln  Leu Met Lys Arg Leu  His Val Asn Trp Val  Val Ser Glu 
    1415                 1420                 1425             


Leu Thr  Leu Gly Gln Ile Trp  Asp Val Asp Leu Gln  Lys Asn Glu 
    1430                 1435                 1440             


Ala Ile  Val Lys Asp Val Leu  Leu Val Ala Gln Gly  Glu Met Ala 
    1445                 1450                 1455             


Leu Glu  Glu Phe Leu Lys Gln  Ile Arg Glu Val Trp  Asn Thr Tyr 
    1460                 1465                 1470             


Glu Leu  Asp Leu Val Asn Tyr  Gln Asn Lys Cys Arg  Leu Ile Arg 
    1475                 1480                 1485             


Gly Trp  Asp Asp Leu Phe Asn  Lys Val Lys Glu His  Ile Asn Ser 
    1490                 1495                 1500             


Val Ser  Ala Met Lys Leu Ser  Pro Tyr Tyr Lys Val  Phe Glu Glu 
    1505                 1510                 1515             


Asp Ala  Leu Ser Trp Glu Asp  Lys Leu Asn Arg Ile  Met Ala Leu 
    1520                 1525                 1530             


Phe Asp  Val Trp Ile Asp Val  Gln Arg Arg Trp Val  Tyr Leu Glu 
    1535                 1540                 1545             


Gly Ile  Phe Thr Gly Ser Ala  Asp Ile Lys His Leu  Leu Pro Val 
    1550                 1555                 1560             


Glu Thr  Gln Arg Phe Gln Ser  Ile Ser Thr Glu Phe  Leu Ala Leu 
    1565                 1570                 1575             


Met Lys  Lys Val Ser Lys Ser  Pro Leu Val Met Asp  Val Leu Asn 
    1580                 1585                 1590             


Ile Gln  Gly Val Gln Arg Ser  Leu Glu Arg Leu Ala  Asp Leu Leu 
    1595                 1600                 1605             


Gly Lys  Ile Gln Lys Ala Leu  Gly Glu Tyr Leu Glu  Arg Glu Arg 
    1610                 1615                 1620             


Ser Ser  Phe Pro Arg Phe Tyr  Phe Val Gly Asp Glu  Asp Leu Leu 
    1625                 1630                 1635             


Glu Ile  Ile Gly Asn Ser Lys  Asn Val Ala Lys Leu  Gln Lys His 
    1640                 1645                 1650             


Phe Lys  Lys Met Phe Ala Gly  Val Ser Ser Ile Ile  Leu Asn Glu 
    1655                 1660                 1665             


Asp Asn  Ser Val Val Leu Gly  Ile Ser Ser Arg Glu  Gly Glu Glu 
    1670                 1675                 1680             


Val Met  Phe Lys Thr Pro Val  Ser Ile Thr Glu His  Pro Lys Ile 
    1685                 1690                 1695             


Asn Glu  Trp Leu Thr Leu Val  Glu Lys Glu Met Arg  Val Thr Leu 
    1700                 1705                 1710             


Ala Lys  Leu Leu Ala Glu Ser  Val Thr Glu Val Glu  Ile Phe Gly 
    1715                 1720                 1725             


Lys Ala  Thr Ser Ile Asp Pro  Asn Thr Tyr Ile Thr  Trp Ile Asp 
    1730                 1735                 1740             


Lys Tyr  Gln Ala Gln Leu Val  Val Leu Ser Ala Gln  Ile Ala Trp 
    1745                 1750                 1755             


Ser Glu  Asn Val Glu Thr Ala  Leu Ser Ser Met Gly  Gly Gly Gly 
    1760                 1765                 1770             


Asp Ala  Ala Pro Leu His Ser  Val Leu Ser Asn Val  Glu Val Thr 
    1775                 1780                 1785             


Leu Asn  Val Leu Ala Asp Ser  Val Leu Met Glu Gln  Pro Pro Leu 
    1790                 1795                 1800             


Arg Arg  Arg Lys Leu Glu His  Leu Ile Thr Glu Leu  Val His Gln 
    1805                 1810                 1815             


Arg Asp  Val Thr Arg Ser Leu  Ile Lys Ser Lys Ile  Asp Asn Ala 
    1820                 1825                 1830             


Lys Ser  Phe Glu Trp Leu Ser  Gln Met Arg Phe Tyr  Phe Asp Pro 
    1835                 1840                 1845             


Lys Gln  Thr Asp Val Leu Gln  Gln Leu Ser Ile Gln  Met Ala Asn 
    1850                 1855                 1860             


Ala Lys  Phe Asn Tyr Gly Phe  Glu Tyr Leu Gly Val  Gln Asp Lys 
    1865                 1870                 1875             


Leu Val  Gln Thr Pro Leu Thr  Asp Arg Cys Tyr Leu  Thr Met Thr 
    1880                 1885                 1890             


Gln Ala  Leu Glu Ala Arg Leu  Gly Gly Ser Pro Phe  Gly Pro Ala 
    1895                 1900                 1905             


Gly Thr  Gly Lys Thr Glu Ser  Val Lys Ala Leu Gly  His Gln Leu 
    1910                 1915                 1920             


Gly Arg  Phe Val Leu Val Phe  Asn Cys Asp Glu Thr  Phe Asp Phe 
    1925                 1930                 1935             


Gln Ala  Met Gly Arg Ile Phe  Val Gly Leu Cys Gln  Val Gly Ala 
    1940                 1945                 1950             


Trp Gly  Cys Phe Asp Glu Phe  Asn Arg Leu Glu Glu  Arg Met Leu 
    1955                 1960                 1965             


Ser Ala  Val Ser Gln Gln Val  Gln Cys Ile Gln Glu  Ala Leu Arg 
    1970                 1975                 1980             


Glu His  Ser Asn Pro Asn Tyr  Asp Lys Thr Ser Ala  Pro Ile Thr 
    1985                 1990                 1995             


Cys Glu  Leu Leu Asn Lys Gln  Val Lys Val Ser Pro  Asp Met Ala 
    2000                 2005                 2010             


Ile Phe  Ile Thr Met Asn Pro  Gly Tyr Ala Gly Arg  Ser Asn Leu 
    2015                 2020                 2025             


Pro Asp  Asn Leu Lys Lys Leu  Phe Arg Ser Leu Ala  Met Thr Lys 
    2030                 2035                 2040             


Pro Asp  Arg Gln Leu Ile Ala  Gln Val Met Leu Tyr  Ser Gln Gly 
    2045                 2050                 2055             


Phe Arg  Thr Ala Glu Val Leu  Ala Asn Lys Ile Val  Pro Phe Phe 
    2060                 2065                 2070             


Lys Leu  Cys Asp Glu Gln Leu  Ser Ser Gln Ser His  Tyr Asp Phe 
    2075                 2080                 2085             


Gly Leu  Arg Ala Leu Lys Ser  Val Leu Val Ser Ala  Gly Asn Val 
    2090                 2095                 2100             


Lys Arg  Glu Arg Ile Gln Lys  Ile Lys Arg Glu Lys  Glu Glu Arg 
    2105                 2110                 2115             


Gly Glu  Ala Val Asp Glu Gly  Glu Ile Ala Glu Asn  Leu Pro Glu 
    2120                 2125                 2130             


Gln Glu  Ile Leu Ile Gln Ser  Val Cys Glu Thr Met  Val Pro Lys 
    2135                 2140                 2145             


Leu Val  Ala Glu Asp Ile Pro  Leu Leu Phe Ser Leu  Leu Ser Asp 
    2150                 2155                 2160             


Val Phe  Pro Gly Val Gln Tyr  His Arg Gly Glu Met  Thr Ala Leu 
    2165                 2170                 2175             


Arg Glu  Glu Leu Lys Lys Val  Cys Gln Glu Met Tyr  Leu Thr Tyr 
    2180                 2185                 2190             


Gly Asp  Gly Glu Glu Val Gly  Gly Met Trp Val Glu  Lys Val Leu 
    2195                 2200                 2205             


Gln Leu  Tyr Gln Ile Thr Gln  Ile Asn His Gly Leu  Met Met Val 
    2210                 2215                 2220             


Gly Pro  Ser Gly Ser Gly Lys  Ser Met Ala Trp Arg  Val Leu Leu 
    2225                 2230                 2235             


Lys Ala  Leu Glu Arg Leu Glu  Gly Val Glu Gly Val  Ala His Ile 
    2240                 2245                 2250             


Ile Asp  Pro Lys Ala Ile Ser  Lys Asp His Leu Tyr  Gly Thr Leu 
    2255                 2260                 2265             


Asp Pro  Asn Thr Arg Glu Trp  Thr Asp Gly Leu Phe  Thr His Val 
    2270                 2275                 2280             


Leu Arg  Lys Ile Ile Asp Ser  Val Arg Gly Glu Leu  Gln Lys Arg 
    2285                 2290                 2295             


Gln Trp  Ile Val Phe Asp Gly  Asp Val Asp Pro Glu  Trp Val Glu 
    2300                 2305                 2310             


Asn Leu  Asn Ser Val Leu Asp  Asp Asn Lys Leu Leu  Thr Leu Pro 
    2315                 2320                 2325             


Asn Gly  Glu Arg Leu Ser Leu  Pro Pro Asn Val Arg  Ile Met Phe 
    2330                 2335                 2340             


Glu Val  Gln Asp Leu Lys Tyr  Ala Thr Leu Ala Thr  Val Ser Arg 
    2345                 2350                 2355             


Cys Gly  Met Val Trp Phe Ser  Glu Asp Val Leu Ser  Thr Asp Met 
    2360                 2365                 2370             


Ile Phe  Asn Asn Phe Leu Ala  Arg Leu Arg Ser Ile  Pro Leu Asp 
    2375                 2380                 2385             


Glu Gly  Glu Asp Glu Ala Gln  Arg Arg Arg Lys Gly  Lys Glu Asp 
    2390                 2395                 2400             


Glu Gly  Glu Glu Ala Ala Ser  Pro Met Leu Gln Ile  Gln Arg Asp 
    2405                 2410                 2415             


Ala Ala  Thr Ile Met Gln Pro  Tyr Phe Thr Ser Asn  Gly Leu Val 
    2420                 2425                 2430             


Thr Lys  Ala Leu Glu His Ala  Phe Gln Leu Glu His  Ile Met Asp 
    2435                 2440                 2445             


Leu Thr  Arg Leu Arg Cys Leu  Gly Ser Leu Phe Ser  Met Leu His 
    2450                 2455                 2460             


Gln Ala  Cys Arg Asn Val Ala  Gln Tyr Asn Ala Asn  His Pro Asp 
    2465                 2470                 2475             


Phe Pro  Met Gln Ile Glu Gln  Leu Glu Arg Tyr Ile  Gln Arg Tyr 
    2480                 2485                 2490             


Leu Val  Tyr Ala Ile Leu Trp  Ser Leu Ser Gly Asp  Ser Arg Leu 
    2495                 2500                 2505             


Lys Met  Arg Ala Glu Leu Gly  Glu Tyr Ile Arg Arg  Ile Thr Thr 
    2510                 2515                 2520             


Val Pro  Leu Pro Thr Ala Pro  Asn Ile Pro Ile Ile  Asp Tyr Glu 
    2525                 2530                 2535             


Val Ser  Ile Ser Gly Glu Trp  Ser Pro Trp Gln Ala  Lys Val Pro 
    2540                 2545                 2550             


Gln Ile  Glu Val Glu Thr His  Lys Val Ala Ala Pro  Asp Val Val 
    2555                 2560                 2565             


Val Pro  Thr Leu Asp Thr Val  Arg His Glu Ala Leu  Leu Tyr Thr 
    2570                 2575                 2580             


Trp Leu  Ala Glu His Lys Pro  Leu Val Leu Cys Gly  Pro Pro Gly 
    2585                 2590                 2595             


Ser Gly  Lys Thr Met Thr Leu  Phe Ser Ala Leu Arg  Ala Leu Pro 
    2600                 2605                 2610             


Asp Met  Glu Val Val Gly Leu  Asn Phe Ser Ser Ala  Thr Thr Pro 
    2615                 2620                 2625             


Glu Leu  Leu Leu Lys Thr Phe  Asp His Tyr Cys Glu  Tyr Arg Arg 
    2630                 2635                 2640             


Thr Pro  Asn Gly Val Val Leu  Ala Pro Val Gln Leu  Gly Lys Trp 
    2645                 2650                 2655             


Leu Val  Leu Phe Cys Asp Glu  Ile Asn Leu Pro Asp  Met Asp Lys 
    2660                 2665                 2670             


Tyr Gly  Thr Gln Arg Val Ile  Ser Phe Ile Arg Gln  Met Val Glu 
    2675                 2680                 2685             


His Gly  Gly Phe Tyr Arg Thr  Ser Asp Gln Thr Trp  Val Lys Leu 
    2690                 2695                 2700             


Glu Arg  Ile Gln Phe Val Gly  Ala Cys Asn Pro Pro  Thr Asp Pro 
    2705                 2710                 2715             


Gly Arg  Lys Pro Leu Ser His  Arg Phe Leu Arg His  Val Pro Val 
    2720                 2725                 2730             


Val Tyr  Val Asp Tyr Pro Gly  Pro Ala Ser Leu Thr  Gln Ile Tyr 
    2735                 2740                 2745             


Gly Thr  Phe Asn Arg Ala Met  Leu Arg Leu Ile Pro  Ser Leu Arg 
    2750                 2755                 2760             


Thr Tyr  Ala Glu Pro Leu Thr  Ala Ala Met Val Glu  Phe Tyr Thr 
    2765                 2770                 2775             


Met Ser  Gln Glu Arg Phe Thr  Gln Asp Thr Gln Pro  His Tyr Ile 
    2780                 2785                 2790             


Tyr Ser  Pro Arg Glu Met Thr  Arg Trp Val Arg Gly  Ile Phe Glu 
    2795                 2800                 2805             


Ala Leu  Arg Pro Leu Glu Thr  Leu Pro Val Glu Gly  Leu Ile Arg 
    2810                 2815                 2820             


Ile Trp  Ala His Glu Ala Leu  Arg Leu Phe Gln Asp  Arg Leu Val 
    2825                 2830                 2835             


Glu Asp  Glu Glu Arg Arg Trp  Thr Asp Glu Asn Ile  Asp Thr Val 
    2840                 2845                 2850             


Ala Leu  Lys His Phe Pro Asn  Ile Asp Arg Glu Lys  Ala Met Ser 
    2855                 2860                 2865             


Arg Pro  Ile Leu Tyr Ser Asn  Trp Leu Ser Lys Asp  Tyr Ile Pro 
    2870                 2875                 2880             


Val Asp  Gln Glu Glu Leu Arg  Asp Tyr Val Lys Ala  Arg Leu Lys 
    2885                 2890                 2895             


Val Phe  Tyr Glu Glu Glu Leu  Asp Val Pro Leu Val  Leu Phe Asn 
    2900                 2905                 2910             


Glu Val  Leu Asp His Val Leu  Arg Ile Asp Arg Ile  Phe Arg Gln 
    2915                 2920                 2925             


Pro Gln  Gly His Leu Leu Leu  Ile Gly Val Ser Gly  Ala Gly Lys 
    2930                 2935                 2940             


Thr Thr  Leu Ser Arg Phe Val  Ala Trp Met Asn Gly  Leu Ser Val 
    2945                 2950                 2955             


Tyr Gln  Ile Lys Val His Arg  Lys Tyr Thr Gly Glu  Asp Phe Asp 
    2960                 2965                 2970             


Glu Asp  Leu Arg Thr Val Leu  Arg Arg Ser Gly Cys  Lys Asn Glu 
    2975                 2980                 2985             


Lys Ile  Ala Phe Ile Met Asp  Glu Ser Asn Val Leu  Asp Ser Gly 
    2990                 2995                 3000             


Phe Leu  Glu Arg Met Asn Thr  Leu Leu Ala Asn Gly  Glu Val Pro 
    3005                 3010                 3015             


Gly Leu  Phe Glu Gly Asp Glu  Tyr Ala Thr Leu Met  Thr Gln Cys 
    3020                 3025                 3030             


Lys Glu  Gly Ala Gln Lys Glu  Gly Leu Met Leu Asp  Ser His Glu 
    3035                 3040                 3045             


Glu Leu  Tyr Lys Trp Phe Thr  Ser Gln Val Ile Arg  Asn Leu His 
    3050                 3055                 3060             


Val Val  Phe Thr Met Asn Pro  Ser Ser Glu Gly Leu  Lys Asp Arg 
    3065                 3070                 3075             


Ala Ala  Thr Ser Pro Ala Leu  Phe Asn Arg Cys Val  Leu Asn Trp 
    3080                 3085                 3090             


Phe Gly  Asp Trp Ser Thr Glu  Ala Leu Tyr Gln Val  Gly Lys Glu 
    3095                 3100                 3105             


Phe Thr  Ser Lys Met Asp Leu  Glu Lys Pro Asn Tyr  Ile Val Pro 
    3110                 3115                 3120             


Asp Tyr  Met Pro Val Val Tyr  Asp Lys Leu Pro Gln  Pro Pro Ser 
    3125                 3130                 3135             


His Arg  Glu Ala Ile Val Asn  Ser Cys Val Phe Val  His Gln Thr 
    3140                 3145                 3150             


Leu His  Gln Ala Asn Ala Arg  Leu Ala Lys Arg Gly  Gly Arg Thr 
    3155                 3160                 3165             


Met Ala  Ile Thr Pro Arg His  Tyr Leu Asp Phe Ile  Asn His Tyr 
    3170                 3175                 3180             


Ala Asn  Leu Phe His Glu Lys  Arg Ser Glu Leu Glu  Glu Gln Gln 
    3185                 3190                 3195             


Met His  Leu Asn Val Gly Leu  Arg Lys Ile Lys Glu  Thr Val Asp 
    3200                 3205                 3210             


Gln Val  Glu Glu Leu Arg Arg  Asp Leu Arg Ile Lys  Ser Gln Glu 
    3215                 3220                 3225             


Leu Glu  Val Lys Asn Ala Ala  Ala Asn Asp Lys Leu  Lys Lys Met 
    3230                 3235                 3240             


Val Lys  Asp Gln Gln Glu Ala  Glu Lys Lys Lys Val  Met Ser Gln 
    3245                 3250                 3255             


Glu Ile  Gln Glu Gln Leu His  Lys Gln Gln Glu Val  Ile Ala Asp 
    3260                 3265                 3270             


Lys Gln  Met Ser Val Lys Glu  Asp Leu Asp Lys Val  Glu Pro Ala 
    3275                 3280                 3285             


Val Ile  Glu Ala Gln Asn Ala  Val Lys Ser Ile Lys  Lys Gln His 
    3290                 3295                 3300             


Leu Val  Glu Val Arg Ser Met  Ala Asn Pro Pro Ala  Ala Val Lys 
    3305                 3310                 3315             


Leu Ala  Leu Glu Ser Ile Cys  Leu Leu Leu Gly Glu  Ser Thr Thr 
    3320                 3325                 3330             


Asp Trp  Lys Gln Ile Arg Ser  Ile Ile Met Arg Glu  Asn Phe Ile 
    3335                 3340                 3345             


Pro Thr  Ile Val Asn Phe Ser  Ala Glu Glu Ile Ser  Asp Ala Ile 
    3350                 3355                 3360             


Arg Glu  Lys Met Lys Lys Asn  Tyr Met Ser Asn Pro  Ser Tyr Asn 
    3365                 3370                 3375             


Tyr Glu  Ile Val Asn Arg Ala  Ser Leu Ala Cys Gly  Pro Met Val 
    3380                 3385                 3390             


Lys Trp  Ala Ile Ala Gln Leu  Asn Tyr Ala Asp Met  Leu Lys Arg 
    3395                 3400                 3405             


Val Glu  Pro Leu Arg Asn Glu  Leu Gln Lys Leu Glu  Asp Asp Ala 
    3410                 3415                 3420             


Lys Asp  Asn Gln Gln Lys Ala  Asn Glu Val Glu Gln  Met Ile Arg 
    3425                 3430                 3435             


Asp Leu  Glu Ala Ser Ile Ala  Arg Tyr Lys Glu Glu  Tyr Ala Val 
    3440                 3445                 3450             


Leu Ile  Ser Glu Ala Gln Ala  Ile Lys Ala Asp Leu  Ala Ala Val 
    3455                 3460                 3465             


Glu Ala  Lys Val Asn Arg Ser  Thr Ala Leu Leu Lys  Ser Leu Ser 
    3470                 3475                 3480             


Ala Glu  Arg Glu Arg Trp Glu  Lys Thr Ser Glu Thr  Phe Lys Asn 
    3485                 3490                 3495             


Gln Met  Ser Thr Ile Ala Gly  Asp Cys Leu Leu Ser  Ala Ala Phe 
    3500                 3505                 3510             


Ile Ala  Tyr Ala Gly Tyr Phe  Asp Gln Gln Met Arg  Gln Asn Leu 
    3515                 3520                 3525             


Phe Thr  Thr Trp Ser His His  Leu Gln Gln Ala Asn  Ile Gln Phe 
    3530                 3535                 3540             


Arg Thr  Asp Ile Ala Arg Thr  Glu Tyr Leu Ser Asn  Ala Asp Glu 
    3545                 3550                 3555             


Arg Leu  Arg Trp Gln Ala Ser  Ser Leu Pro Ala Asp  Asp Leu Cys 
    3560                 3565                 3570             


Thr Glu  Asn Ala Ile Met Leu  Lys Arg Phe Asn Arg  Tyr Pro Leu 
    3575                 3580                 3585             


Ile Ile  Asp Pro Ser Gly Gln  Ala Thr Glu Phe Ile  Met Asn Glu 
    3590                 3595                 3600             


Tyr Lys  Asp Arg Lys Ile Thr  Arg Thr Ser Phe Leu  Asp Asp Ala 
    3605                 3610                 3615             


Phe Arg  Lys Asn Leu Glu Ser  Ala Leu Arg Phe Gly  Asn Pro Leu 
    3620                 3625                 3630             


Leu Val  Gln Asp Val Glu Ser  Tyr Asp Pro Val Leu  Asn Pro Val 
    3635                 3640                 3645             


Leu Asn  Arg Glu Val Arg Arg  Thr Gly Gly Arg Val  Leu Ile Thr 
    3650                 3655                 3660             


Leu Gly  Asp Gln Asp Ile Asp  Leu Ser Pro Ser Phe  Val Ile Phe 
    3665                 3670                 3675             


Leu Ser  Thr Arg Asp Pro Thr  Val Glu Phe Pro Pro  Asp Leu Cys 
    3680                 3685                 3690             


Ser Arg  Val Thr Phe Val Asn  Phe Thr Val Thr Arg  Ser Ser Leu 
    3695                 3700                 3705             


Gln Ser  Gln Cys Leu Asn Glu  Val Leu Lys Ala Glu  Arg Pro Asp 
    3710                 3715                 3720             


Val Asp  Glu Lys Arg Ser Asp  Leu Leu Lys Leu Gln  Gly Glu Phe 
    3725                 3730                 3735             


Gln Leu  Arg Leu Arg Gln Leu  Glu Lys Ser Leu Leu  Gln Ala Leu 
    3740                 3745                 3750             


Asn Glu  Val Lys Gly Arg Ile  Leu Asp Asp Asp Thr  Ile Ile Thr 
    3755                 3760                 3765             


Thr Leu  Glu Asn Leu Lys Arg  Glu Ala Ala Glu Val  Thr Arg Lys 
    3770                 3775                 3780             


Val Glu  Glu Thr Asp Ile Val  Met Gln Glu Val Glu  Thr Val Ser 
    3785                 3790                 3795             


Gln Gln  Tyr Leu Pro Leu Ser  Thr Ala Cys Ser Ser  Ile Tyr Phe 
    3800                 3805                 3810             


Thr Met  Glu Ser Leu Lys Gln  Ile His Phe Leu Tyr  Gln Tyr Ser 
    3815                 3820                 3825             


Leu Gln  Phe Phe Leu Asp Ile  Tyr His Asn Val Leu  Tyr Glu Asn 
    3830                 3835                 3840             


Pro Asn  Leu Lys Gly Val Thr  Asp His Thr Gln Arg  Leu Ser Ile 
    3845                 3850                 3855             


Ile Thr  Lys Asp Leu Phe Gln  Val Ala Phe Asn Arg  Val Ala Arg 
    3860                 3865                 3870             


Gly Met  Leu His Gln Asp His  Ile Thr Phe Ala Met  Leu Leu Ala 
    3875                 3880                 3885             


Arg Ile  Lys Leu Lys Gly Thr  Val Gly Glu Pro Thr  Tyr Asp Ala 
    3890                 3895                 3900             


Glu Phe  Gln His Phe Leu Arg  Gly Asn Glu Ile Val  Leu Ser Ala 
    3905                 3910                 3915             


Gly Ser  Thr Pro Arg Ile Gln  Gly Leu Thr Val Glu  Gln Ala Glu 
    3920                 3925                 3930             


Ala Val  Val Arg Leu Ser Cys  Leu Pro Ala Phe Lys  Asp Leu Ile 
    3935                 3940                 3945             


Ala Lys  Val Gln Ala Asp Glu  Gln Phe Gly Ile Trp  Leu Asp Ser 
    3950                 3955                 3960             


Ser Ser  Pro Glu Gln Thr Val  Pro Tyr Leu Trp Ser  Glu Glu Thr 
    3965                 3970                 3975             


Pro Ala  Thr Pro Ile Gly Gln  Ala Ile His Arg Leu  Leu Leu Ile 
    3980                 3985                 3990             


Gln Ala  Phe Arg Pro Asp Arg  Leu Leu Ala Met Ala  His Met Phe 
    3995                 4000                 4005             


Val Ser  Thr Asn Leu Gly Glu  Ser Phe Met Ser Ile  Met Glu Gln 
    4010                 4015                 4020             


Pro Leu  Asp Leu Thr His Ile  Val Gly Thr Glu Val  Lys Pro Asn 
    4025                 4030                 4035             


Thr Pro  Val Leu Met Cys Ser  Val Pro Gly Tyr Asp  Ala Ser Gly 
    4040                 4045                 4050             


His Val  Glu Asp Leu Ala Ala  Glu Gln Asn Thr Gln  Ile Thr Ser 
    4055                 4060                 4065             


Ile Ala  Ile Gly Ser Ala Glu  Gly Phe Asn Gln Ala  Asp Lys Ala 
    4070                 4075                 4080             


Ile Asn  Thr Ala Val Lys Ser  Gly Arg Trp Val Met  Leu Lys Asn 
    4085                 4090                 4095             


Val His  Leu Ala Pro Gly Trp  Leu Met Gln Leu Glu  Lys Lys Leu 
    4100                 4105                 4110             


His Ser  Leu Gln Pro His Ala  Cys Phe Arg Leu Phe  Leu Thr Met 
    4115                 4120                 4125             


Glu Ile  Asn Pro Lys Val Pro  Val Asn Leu Leu Arg  Ala Gly Arg 
    4130                 4135                 4140             


Ile Phe  Val Phe Glu Pro Pro  Pro Gly Val Lys Ala  Asn Met Leu 
    4145                 4150                 4155             


Arg Thr  Phe Ser Ser Ile Pro  Val Ser Arg Ile Cys  Lys Ser Pro 
    4160                 4165                 4170             


Asn Glu  Arg Ala Arg Leu Tyr  Phe Leu Leu Ala Trp  Phe His Ala 
    4175                 4180                 4185             


Ile Ile  Gln Glu Arg Leu Arg  Tyr Ala Pro Leu Gly  Trp Ser Lys 
    4190                 4195                 4200             


Lys Tyr  Glu Phe Gly Glu Ser  Asp Leu Arg Ser Ala  Cys Asp Thr 
    4205                 4210                 4215             


Val Asp  Thr Trp Leu Asp Asp  Thr Ala Lys Gly Arg  Gln Asn Ile 
    4220                 4225                 4230             


Ser Pro  Asp Lys Ile Pro Trp  Ser Ala Leu Lys Thr  Leu Met Ala 
    4235                 4240                 4245             


Gln Ser  Ile Tyr Gly Gly Arg  Val Asp Asn Glu Phe  Asp Gln Arg 
    4250                 4255                 4260             


Leu Leu  Asn Thr Phe Leu Glu  Arg Leu Phe Thr Thr  Arg Ser Phe 
    4265                 4270                 4275             


Asp Ser  Glu Phe Lys Leu Ala  Cys Lys Val Asp Gly  His Lys Asp 
    4280                 4285                 4290             


Ile Gln  Met Pro Asp Gly Ile  Arg Arg Glu Glu Phe  Val Gln Trp 
    4295                 4300                 4305             


Val Glu  Leu Leu Pro Asp Thr  Gln Thr Pro Ser Trp  Leu Gly Leu 
    4310                 4315                 4320             


Pro Asn  Asn Ala Glu Arg Val  Leu Leu Thr Thr Gln  Gly Val Asp 
    4325                 4330                 4335             


Met Ile  Ser Lys Met Leu Lys  Met Gln Met Leu Glu  Asp Glu Asp 
    4340                 4345                 4350             


Asp Leu  Ala Tyr Ala Glu Thr  Glu Lys Lys Thr Arg  Thr Asp Ser 
    4355                 4360                 4365             


Thr Ser  Asp Gly Arg Pro Ala  Trp Met Arg Thr Leu  His Thr Thr 
    4370                 4375                 4380             


Ala Ser  Asn Trp Leu His Leu  Ile Pro Gln Thr Leu  Ser His Leu 
    4385                 4390                 4395             


Lys Arg  Thr Val Glu Asn Ile  Lys Asp Pro Leu Phe  Arg Phe Phe 
    4400                 4405                 4410             


Glu Arg  Glu Val Lys Met Gly  Ala Lys Leu Leu Gln  Asp Val Arg 
    4415                 4420                 4425             


Gln Asp  Leu Ala Asp Val Val  Gln Val Cys Glu Gly  Lys Lys Lys 
    4430                 4435                 4440             


Gln Thr  Asn Tyr Leu Arg Thr  Leu Ile Asn Glu Leu  Val Lys Gly 
    4445                 4450                 4455             


Ile Leu  Pro Arg Ser Trp Ser  His Tyr Thr Val Pro  Ala Gly Met 
    4460                 4465                 4470             


Thr Val  Ile Gln Trp Val Ser  Asp Phe Ser Glu Arg  Ile Lys Gln 
    4475                 4480                 4485             


Leu Gln  Asn Ile Ser Leu Ala  Ala Ala Ser Gly Gly  Ala Lys Glu 
    4490                 4495                 4500             


Leu Lys  Asn Ile His Val Cys  Leu Gly Gly Leu Phe  Val Pro Glu 
    4505                 4510                 4515             


Ala Tyr  Ile Thr Ala Thr Arg  Gln Tyr Val Ala Gln  Ala Asn Ser 
    4520                 4525                 4530             


Trp Ser  Leu Glu Glu Leu Cys  Leu Glu Val Asn Val  Thr Thr Ser 
    4535                 4540                 4545             


Gln Gly  Ala Thr Leu Asp Ala  Cys Ser Phe Gly Val  Thr Gly Leu 
    4550                 4555                 4560             


Lys Leu  Gln Gly Ala Thr Cys  Asn Asn Asn Lys Leu  Ser Leu Ser 
    4565                 4570                 4575             


Asn Ala  Ile Ser Thr Ala Leu  Pro Leu Thr Gln Leu  Arg Trp Val 
    4580                 4585                 4590             


Lys Gln  Thr Asn Thr Glu Lys  Lys Ala Ser Val Val  Thr Leu Pro 
    4595                 4600                 4605             


Val Tyr  Leu Asn Phe Thr Arg  Ala Asp Leu Ile Phe  Thr Val Asp 
    4610                 4615                 4620             


Phe Glu  Ile Ala Thr Lys Glu  Asp Pro Arg Ser Phe  Tyr Glu Arg 
    4625                 4630                 4635             


Gly Val  Ala Val Leu Cys Thr  Glu 
    4640                 4645     


<210>  3334
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNC1I1__Homo_sapiens__NP_001129029

<400>  3334

Met Ser Asp Lys Ser Asp Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Ala Asp Met Gln Gln Lys Lys Glu Pro Val Gln Asp 
        35                  40                  45              


Asp Ser Asp Leu Asp Arg Lys Arg Arg Glu Thr Glu Ala Leu Leu Gln 
    50                  55                  60                  


Ser Ile Gly Ile Ser Pro Glu Pro Pro Leu Val Pro Thr Pro Met Ser 
65                  70                  75                  80  


Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly Ser Gln Asp 
                85                  90                  95      


Ser Gly Asp Leu Gly Pro Leu Thr Arg Arg Arg Leu His Lys Leu Gly 
            100                 105                 110         


Val Ser Lys Val Thr Gln Val Asp Phe Leu Pro Arg Glu Val Val Ser 
        115                 120                 125             


Tyr Ser Lys Glu Thr Gln Thr Pro Leu Ala Thr His Gln Ser Glu Glu 
    130                 135                 140                 


Asp Glu Glu Asp Glu Glu Met Val Glu Ser Lys Val Gly Gln Asp Ser 
145                 150                 155                 160 


Glu Leu Glu Asn Gln Asp Lys Lys Gln Glu Val Lys Glu Ala Pro Pro 
                165                 170                 175     


Arg Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile Leu His Ser Glu Glu 
            180                 185                 190         


Phe Leu Ile Phe Phe Asp Arg Thr Ile Arg Val Ile Glu Arg Ala Leu 
        195                 200                 205             


Ala Glu Asp Ser Asp Ile Phe Phe Asp Tyr Ser Gly Arg Glu Leu Glu 
    210                 215                 220                 


Glu Lys Asp Gly Asp Val Gln Ala Gly Ala Asn Leu Ser Phe Asn Arg 
225                 230                 235                 240 


Gln Phe Tyr Asp Glu His Trp Ser Lys His Arg Val Val Thr Cys Met 
                245                 250                 255     


Asp Trp Ser Leu Gln Tyr Pro Glu Leu Met Val Ala Ser Tyr Asn Asn 
            260                 265                 270         


Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val Ala Leu Val Trp Asn 
        275                 280                 285             


Met Lys Phe Lys Lys Thr Thr Pro Glu Tyr Val Phe His Cys Gln Ser 
    290                 295                 300                 


Ser Val Met Ser Val Cys Phe Ala Arg Phe His Pro Asn Leu Val Val 
305                 310                 315                 320 


Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp Asp Asn Arg Ser His 
                325                 330                 335     


Arg Arg Thr Pro Val Gln Arg Thr Pro Leu Ser Ala Ala Ala His Thr 
            340                 345                 350         


His Pro Val Tyr Cys Val Asn Val Val Gly Thr Gln Asn Ala His Asn 
        355                 360                 365             


Leu Ile Thr Val Ser Thr Asp Gly Lys Met Cys Ser Trp Ser Leu Asp 
    370                 375                 380                 


Met Leu Ser Thr Pro Gln Glu Ser Met Glu Leu Val Tyr Asn Lys Ser 
385                 390                 395                 400 


Lys Pro Val Ala Val Thr Gly Met Ala Phe Pro Thr Gly Asp Val Asn 
                405                 410                 415     


Asn Phe Val Val Gly Ser Glu Glu Gly Thr Val Tyr Thr Ala Cys Arg 
            420                 425                 430         


His Gly Ser Lys Ala Gly Ile Gly Glu Val Phe Glu Gly His Gln Gly 
        435                 440                 445             


Pro Val Thr Gly Ile Asn Cys His Met Ala Val Gly Pro Ile Asp Phe 
    450                 455                 460                 


Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp Thr Val Lys Leu Trp 
465                 470                 475                 480 


Thr Thr Lys His Asn Lys Pro Leu Tyr Ser Phe Glu Asp Asn Ala Asp 
                485                 490                 495     


Tyr Val Tyr Asp Val Met Trp Ser Pro Val His Pro Ala Leu Phe Ala 
            500                 505                 510         


Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp Asn Leu Asn Asn Asp 
        515                 520                 525             


Thr Glu Val Pro Thr Ala Ser Val Ala Ile Glu Gly Ala Ser Ala Leu 
    530                 535                 540                 


Asn Arg Val Arg Trp Ala Gln Ala Gly Lys Glu Val Ala Val Gly Asp 
545                 550                 555                 560 


Ser Glu Gly Arg Ile Trp Val Tyr Asp Val Gly Glu Leu Ala Val Pro 
                565                 570                 575     


His Asn Asp Glu Trp Thr Arg Phe Ala Arg Thr Leu Val Glu Ile Arg 
            580                 585                 590         


Ala Asn Arg Ala Asp Ser Glu Glu Glu Gly Thr Val Glu Leu Ser Ala 
        595                 600                 605             


<210>  3335
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNC1I2__Homo_sapiens__NP_001258715

<400>  3335

Met Ser Asp Lys Ser Glu Leu Lys Ala Glu Leu Glu Arg Lys Lys Gln 
1               5                   10                  15      


Arg Leu Ala Gln Ile Arg Glu Glu Lys Lys Arg Lys Glu Glu Glu Arg 
            20                  25                  30          


Lys Lys Lys Glu Thr Asp Gln Lys Lys Glu Ala Val Ala Pro Val Gln 
        35                  40                  45              


Glu Glu Ser Asp Leu Glu Lys Lys Arg Arg Glu Ala Glu Ala Leu Leu 
    50                  55                  60                  


Gln Ser Met Gly Leu Thr Pro Glu Ser Pro Ile Ala Glu Gln Pro Leu 
65                  70                  75                  80  


Arg Val Val Thr Ala Asp Thr Cys Leu Phe His Tyr Leu Val Pro Pro 
                85                  90                  95      


Pro Met Ser Pro Ser Ser Lys Ser Val Ser Thr Pro Ser Glu Ala Gly 
            100                 105                 110         


Ser Gln Asp Ser Gly Asp Gly Ala Val Gly Ser Arg Arg Gly Pro Ile 
        115                 120                 125             


Lys Leu Gly Met Ala Lys Ile Thr Gln Val Asp Phe Pro Pro Arg Glu 
    130                 135                 140                 


Ile Val Thr Tyr Thr Lys Glu Thr Gln Thr Pro Val Met Ala Gln Pro 
145                 150                 155                 160 


Lys Glu Asp Glu Glu Glu Asp Asp Asp Val Val Ala Pro Lys Pro Pro 
                165                 170                 175     


Ile Glu Pro Glu Glu Glu Lys Thr Leu Lys Lys Asp Glu Glu Asn Asp 
            180                 185                 190         


Ser Lys Ala Pro Pro His Glu Leu Thr Glu Glu Glu Lys Gln Gln Ile 
        195                 200                 205             


Leu His Ser Glu Glu Phe Leu Ser Phe Phe Asp His Ser Thr Arg Ile 
    210                 215                 220                 


Val Glu Arg Ala Leu Ser Glu Gln Ile Asn Ile Phe Phe Asp Tyr Ser 
225                 230                 235                 240 


Gly Arg Asp Leu Glu Asp Lys Glu Gly Glu Ile Gln Ala Gly Ala Lys 
                245                 250                 255     


Leu Ser Leu Asn Arg Gln Phe Phe Asp Glu Arg Trp Ser Lys His Arg 
            260                 265                 270         


Val Val Ser Cys Leu Asp Trp Ser Ser Gln Tyr Pro Glu Leu Leu Val 
        275                 280                 285             


Ala Ser Tyr Asn Asn Asn Glu Asp Ala Pro His Glu Pro Asp Gly Val 
    290                 295                 300                 


Ala Leu Val Trp Asn Met Lys Tyr Lys Lys Thr Thr Pro Glu Tyr Val 
305                 310                 315                 320 


Phe His Cys Gln Ser Ala Val Met Ser Ala Thr Phe Ala Lys Phe His 
                325                 330                 335     


Pro Asn Leu Val Val Gly Gly Thr Tyr Ser Gly Gln Ile Val Leu Trp 
            340                 345                 350         


Asp Asn Arg Ser Asn Lys Arg Thr Pro Val Gln Arg Thr Pro Leu Ser 
        355                 360                 365             


Ala Ala Ala His Thr His Pro Val Tyr Cys Val Asn Val Val Gly Thr 
    370                 375                 380                 


Gln Asn Ala His Asn Leu Ile Ser Ile Ser Thr Asp Gly Lys Ile Cys 
385                 390                 395                 400 


Ser Trp Ser Leu Asp Met Leu Ser His Pro Gln Asp Ser Met Glu Leu 
                405                 410                 415     


Val His Lys Gln Ser Lys Ala Val Ala Val Thr Ser Met Ser Phe Pro 
            420                 425                 430         


Val Gly Asp Val Asn Asn Phe Val Val Gly Ser Glu Glu Gly Ser Val 
        435                 440                 445             


Tyr Thr Ala Cys Arg His Gly Ser Lys Ala Gly Ile Ser Glu Met Phe 
    450                 455                 460                 


Glu Gly His Gln Gly Pro Ile Thr Gly Ile His Cys His Ala Ala Val 
465                 470                 475                 480 


Gly Ala Val Asp Phe Ser His Leu Phe Val Thr Ser Ser Phe Asp Trp 
                485                 490                 495     


Thr Val Lys Leu Trp Thr Thr Lys Asn Asn Lys Pro Leu Tyr Ser Phe 
            500                 505                 510         


Glu Asp Asn Ala Asp Tyr Val Tyr Asp Val Met Trp Ser Pro Thr His 
        515                 520                 525             


Pro Ala Leu Phe Ala Cys Val Asp Gly Met Gly Arg Leu Asp Leu Trp 
    530                 535                 540                 


Asn Leu Asn Asn Asp Thr Glu Val Pro Thr Ala Ser Ile Ser Val Glu 
545                 550                 555                 560 


Gly Asn Pro Ala Leu Asn Arg Val Arg Trp Thr His Ser Gly Arg Glu 
                565                 570                 575     


Ile Ala Val Gly Asp Ser Glu Gly Gln Ile Val Ile Tyr Asp Val Gly 
            580                 585                 590         


Glu Gln Ile Ala Val Pro Arg Asn Asp Glu Trp Ala Arg Phe Gly Arg 
        595                 600                 605             


Thr Leu Ala Glu Ile Asn Ala Asn Arg Ala Asp Ala Glu Glu Glu Ala 
    610                 615                 620                 


Ala Thr Arg Ile Pro Ala 
625                 630 


<210>  3336
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNC1LI1__Homo_sapiens__NP_057225

<400>  3336

Met Ala Ala Val Gly Arg Val Gly Ser Phe Gly Ser Ser Pro Pro Gly 
1               5                   10                  15      


Leu Ser Ser Thr Tyr Thr Gly Gly Pro Leu Gly Asn Glu Ile Ala Ser 
            20                  25                  30          


Gly Asn Gly Gly Ala Ala Ala Gly Asp Asp Glu Asp Gly Gln Asn Leu 
        35                  40                  45              


Trp Ser Cys Ile Leu Ser Glu Val Ser Thr Arg Ser Arg Ser Lys Leu 
    50                  55                  60                  


Pro Ala Gly Lys Asn Val Leu Leu Leu Gly Glu Asp Gly Ala Gly Lys 
65                  70                  75                  80  


Thr Ser Leu Ile Arg Lys Ile Gln Gly Ile Glu Glu Tyr Lys Lys Gly 
                85                  90                  95      


Arg Gly Leu Glu Tyr Leu Tyr Leu Asn Val His Asp Glu Asp Arg Asp 
            100                 105                 110         


Asp Gln Thr Arg Cys Asn Val Trp Ile Leu Asp Gly Asp Leu Tyr His 
        115                 120                 125             


Lys Gly Leu Leu Lys Phe Ser Leu Asp Ala Val Ser Leu Lys Asp Thr 
    130                 135                 140                 


Leu Val Met Leu Val Val Asp Met Ser Lys Pro Trp Thr Ala Leu Asp 
145                 150                 155                 160 


Ser Leu Gln Lys Trp Ala Ser Val Val Arg Glu His Val Asp Lys Leu 
                165                 170                 175     


Lys Ile Pro Pro Glu Glu Met Lys Gln Met Glu Gln Lys Leu Ile Arg 
            180                 185                 190         


Asp Phe Gln Glu Tyr Val Glu Pro Gly Glu Asp Phe Pro Ala Ser Pro 
        195                 200                 205             


Gln Arg Arg Asn Thr Ala Ser Gln Glu Asp Lys Asp Asp Ser Val Val 
    210                 215                 220                 


Leu Pro Leu Gly Ala Asp Thr Leu Thr His Asn Leu Gly Ile Pro Val 
225                 230                 235                 240 


Leu Val Val Cys Thr Lys Cys Asp Ala Ile Ser Val Leu Glu Lys Glu 
                245                 250                 255     


His Asp Tyr Arg Asp Glu His Phe Asp Phe Ile Gln Ser His Ile Arg 
            260                 265                 270         


Lys Phe Cys Leu Gln Tyr Gly Ala Ala Leu Ile Tyr Thr Ser Val Lys 
        275                 280                 285             


Glu Asn Lys Asn Ile Asp Leu Val Tyr Lys Tyr Ile Val Gln Lys Leu 
    290                 295                 300                 


Tyr Gly Phe Pro Tyr Lys Ile Pro Ala Val Val Val Glu Lys Asp Ala 
305                 310                 315                 320 


Val Phe Ile Pro Ala Gly Trp Asp Asn Asp Lys Lys Ile Gly Ile Leu 
                325                 330                 335     


His Glu Asn Phe Gln Thr Leu Lys Ala Glu Asp Asn Phe Glu Asp Ile 
            340                 345                 350         


Ile Thr Lys Pro Pro Val Arg Lys Phe Val His Glu Lys Glu Ile Met 
        355                 360                 365             


Ala Glu Asp Asp Gln Val Phe Leu Met Lys Leu Gln Ser Leu Leu Ala 
    370                 375                 380                 


Lys Gln Pro Pro Thr Ala Ala Gly Arg Pro Val Asp Ala Ser Pro Arg 
385                 390                 395                 400 


Val Pro Gly Gly Ser Pro Arg Thr Pro Asn Arg Ser Val Ser Ser Asn 
                405                 410                 415     


Val Ala Ser Val Ser Pro Ile Pro Ala Gly Ser Lys Lys Ile Asp Pro 
            420                 425                 430         


Asn Met Lys Ala Gly Ala Thr Ser Glu Gly Val Leu Ala Asn Phe Phe 
        435                 440                 445             


Asn Ser Leu Leu Ser Lys Lys Thr Gly Ser Pro Gly Gly Pro Gly Val 
    450                 455                 460                 


Ser Gly Gly Ser Pro Ala Gly Gly Ala Gly Gly Gly Ser Ser Gly Leu 
465                 470                 475                 480 


Pro Pro Ser Thr Lys Lys Ser Gly Gln Lys Pro Val Leu Asp Val His 
                485                 490                 495     


Ala Glu Leu Asp Arg Ile Thr Arg Lys Pro Val Thr Val Ser Pro Thr 
            500                 505                 510         


Thr Pro Thr Ser Pro Thr Glu Gly Glu Ala Ser 
        515                 520             


<210>  3337
<211>  4314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNC2H1__Homo_sapiens__NP_001073932

<400>  3337

Met Ala Asn Gly Thr Ala Asp Val Arg Lys Leu Phe Ile Phe Thr Thr 
1               5                   10                  15      


Thr Gln Asn Tyr Phe Gly Leu Met Ser Glu Leu Trp Asp Gln Pro Leu 
            20                  25                  30          


Leu Cys Asn Cys Leu Glu Ile Asn Asn Phe Leu Asp Asp Gly Asn Gln 
        35                  40                  45              


Met Leu Leu Arg Val Gln Arg Ser Asp Ala Gly Ile Ser Phe Ser Asn 
    50                  55                  60                  


Thr Ile Glu Phe Gly Asp Thr Lys Asp Lys Val Leu Val Phe Phe Lys 
65                  70                  75                  80  


Leu Arg Pro Glu Val Ile Thr Asp Glu Asn Leu His Asp Asn Ile Leu 
                85                  90                  95      


Val Ser Ser Met Leu Glu Ser Pro Ile Ser Ser Leu Tyr Gln Ala Val 
            100                 105                 110         


Arg Gln Val Phe Ala Pro Met Leu Leu Lys Asp Gln Glu Trp Ser Arg 
        115                 120                 125             


Asn Phe Asp Pro Lys Leu Gln Asn Leu Leu Ser Glu Leu Glu Ala Gly 
    130                 135                 140                 


Leu Gly Ile Val Leu Arg Arg Ser Asp Thr Asn Leu Thr Lys Leu Lys 
145                 150                 155                 160 


Phe Lys Glu Asp Asp Thr Arg Gly Ile Leu Thr Pro Ser Asp Glu Phe 
                165                 170                 175     


Gln Phe Trp Ile Glu Gln Ala His Arg Gly Asn Lys Gln Ile Ser Lys 
            180                 185                 190         


Glu Arg Ala Asn Tyr Phe Lys Glu Leu Phe Glu Thr Ile Ala Arg Glu 
        195                 200                 205             


Phe Tyr Asn Leu Asp Ser Leu Ser Leu Leu Glu Val Val Asp Leu Val 
    210                 215                 220                 


Glu Thr Thr Gln Asp Val Val Asp Asp Val Trp Arg Gln Thr Glu His 
225                 230                 235                 240 


Asp His Tyr Pro Glu Ser Arg Met Leu His Leu Leu Asp Ile Ile Gly 
                245                 250                 255     


Gly Ser Phe Gly Arg Phe Val Gln Lys Lys Leu Gly Thr Leu Asn Leu 
            260                 265                 270         


Trp Glu Asp Pro Tyr Tyr Leu Val Lys Glu Ser Leu Lys Ala Gly Ile 
        275                 280                 285             


Ser Ile Cys Glu Gln Trp Val Ile Val Cys Asn His Leu Thr Gly Gln 
    290                 295                 300                 


Val Trp Gln Arg Tyr Val Pro His Pro Trp Lys Asn Glu Lys Tyr Phe 
305                 310                 315                 320 


Pro Glu Thr Leu Asp Lys Leu Gly Lys Arg Leu Glu Glu Val Leu Ala 
                325                 330                 335     


Ile Arg Thr Ile His Glu Lys Phe Leu Tyr Phe Leu Pro Ala Ser Glu 
            340                 345                 350         


Glu Lys Ile Ile Cys Leu Thr Arg Val Phe Glu Pro Phe Thr Gly Leu 
        355                 360                 365             


Asn Pro Val Gln Tyr Asn Pro Tyr Thr Glu Pro Leu Trp Lys Ala Ala 
    370                 375                 380                 


Val Ser Gln Tyr Glu Lys Ile Ile Ala Pro Ala Glu Gln Lys Ile Ala 
385                 390                 395                 400 


Gly Lys Leu Lys Asn Tyr Ile Ser Glu Ile Gln Asp Ser Pro Gln Gln 
                405                 410                 415     


Leu Leu Gln Ala Phe Leu Lys Tyr Lys Glu Leu Val Lys Arg Pro Thr 
            420                 425                 430         


Ile Ser Lys Glu Leu Met Leu Glu Arg Glu Thr Leu Leu Ala Arg Leu 
        435                 440                 445             


Val Asp Ser Ile Lys Asp Phe Arg Leu Asp Phe Glu Asn Arg Cys Arg 
    450                 455                 460                 


Gly Ile Pro Gly Asp Ala Ser Gly Pro Leu Ser Gly Lys Asn Leu Ser 
465                 470                 475                 480 


Glu Val Val Asn Ser Ile Val Trp Val Arg Gln Leu Glu Leu Lys Val 
                485                 490                 495     


Asp Asp Thr Ile Lys Ile Ala Glu Ala Leu Leu Ser Asp Leu Pro Gly 
            500                 505                 510         


Phe Arg Cys Phe His Gln Ser Ala Lys Asp Leu Leu Asp Gln Leu Lys 
        515                 520                 525             


Leu Tyr Glu Gln Glu Gln Phe Asp Asp Trp Ser Arg Asp Ile Gln Ser 
    530                 535                 540                 


Gly Leu Ser Asp Ser Arg Ser Gly Leu Cys Ile Glu Ala Ser Ser Arg 
545                 550                 555                 560 


Ile Met Glu Leu Asp Ser Asn Asp Gly Leu Leu Lys Val His Tyr Ser 
                565                 570                 575     


Asp Arg Leu Val Ile Leu Leu Arg Glu Val Arg Gln Leu Ser Ala Leu 
            580                 585                 590         


Gly Phe Val Ile Pro Ala Lys Ile Gln Gln Val Ala Asn Ile Ala Gln 
        595                 600                 605             


Lys Phe Cys Lys Gln Ala Ile Ile Leu Lys Gln Val Ala His Phe Tyr 
    610                 615                 620                 


Asn Ser Ile Asp Gln Gln Met Ile Gln Ser Gln Arg Pro Met Met Leu 
625                 630                 635                 640 


Gln Ser Ala Leu Ala Phe Glu Gln Ile Ile Lys Asn Ser Lys Ala Gly 
                645                 650                 655     


Ser Gly Gly Lys Ser Gln Ile Thr Trp Asp Asn Pro Lys Glu Leu Glu 
            660                 665                 670         


Gly Tyr Ile Gln Lys Leu Gln Asn Ala Ala Glu Arg Leu Ala Thr Glu 
        675                 680                 685             


Asn Arg Lys Leu Arg Lys Trp His Thr Thr Phe Cys Glu Lys Val Val 
    690                 695                 700                 


Val Leu Met Asn Ile Asp Leu Leu Arg Gln Gln Gln Arg Trp Lys Asp 
705                 710                 715                 720 


Gly Leu Gln Glu Leu Arg Thr Gly Leu Ala Thr Val Glu Ala Gln Gly 
                725                 730                 735     


Phe Gln Ala Ser Asp Met His Ala Trp Lys Gln His Trp Asn His Gln 
            740                 745                 750         


Leu Tyr Lys Ala Leu Glu His Gln Tyr Gln Met Gly Leu Glu Ala Leu 
        755                 760                 765             


Asn Glu Asn Leu Pro Glu Ile Asn Ile Asp Leu Thr Tyr Lys Gln Gly 
    770                 775                 780                 


Arg Leu Gln Phe Arg Pro Pro Phe Glu Glu Ile Arg Ala Lys Tyr Tyr 
785                 790                 795                 800 


Arg Glu Met Lys Arg Phe Ile Gly Ile Pro Asn Gln Phe Lys Gly Val 
                805                 810                 815     


Gly Glu Ala Gly Asp Glu Ser Ile Phe Ser Ile Met Ile Asp Arg Asn 
            820                 825                 830         


Ala Ser Gly Phe Leu Thr Ile Phe Ser Lys Ala Glu Asp Leu Phe Arg 
        835                 840                 845             


Arg Leu Ser Ala Val Leu His Gln His Lys Glu Trp Ile Val Ile Gly 
    850                 855                 860                 


Gln Val Asp Met Glu Ala Leu Val Glu Lys His Leu Phe Thr Val His 
865                 870                 875                 880 


Asp Trp Glu Lys Asn Phe Lys Ala Leu Lys Ile Lys Gly Lys Glu Val 
                885                 890                 895     


Glu Arg Leu Pro Ser Ala Val Lys Val Asp Cys Leu Asn Ile Asn Cys 
            900                 905                 910         


Asn Pro Val Lys Thr Val Ile Asp Asp Leu Ile Gln Lys Leu Phe Asp 
        915                 920                 925             


Leu Leu Val Leu Ser Leu Lys Lys Ser Ile Gln Ala His Leu His Glu 
    930                 935                 940                 


Ile Asp Thr Phe Val Thr Glu Ala Met Glu Val Leu Thr Ile Met Pro 
945                 950                 955                 960 


Gln Ser Val Glu Glu Ile Gly Asp Ala Asn Leu Gln Tyr Ser Lys Leu 
                965                 970                 975     


Gln Glu Arg Lys Pro Glu Ile Leu Pro Leu Phe Gln Glu Ala Glu Asp 
            980                 985                 990         


Lys Asn Arg Leu Leu Arg Thr Val  Ala Gly Gly Gly Leu  Glu Thr Ile 
        995                 1000                 1005             


Ser Asn  Leu Lys Ala Lys Trp  Asp Lys Phe Glu Leu  Met Met Glu 
    1010                 1015                 1020             


Ser His  Gln Leu Met Ile Lys  Asp Gln Ile Glu Val  Met Lys Gly 
    1025                 1030                 1035             


Asn Val  Lys Ser Arg Leu Gln  Ile Tyr Tyr Gln Glu  Leu Glu Lys 
    1040                 1045                 1050             


Phe Lys  Ala Arg Trp Asp Gln  Leu Lys Pro Gly Asp  Asp Val Ile 
    1055                 1060                 1065             


Glu Thr  Gly Gln His Asn Thr  Leu Asp Lys Ser Ala  Lys Leu Ile 
    1070                 1075                 1080             


Lys Glu  Lys Lys Ile Glu Phe  Asp Asp Leu Glu Val  Thr Arg Lys 
    1085                 1090                 1095             


Lys Leu  Val Asp Asp Cys His  His Phe Arg Leu Glu  Glu Pro Asn 
    1100                 1105                 1110             


Phe Ser  Leu Ala Ser Ser Ile  Ser Lys Asp Ile Glu  Ser Cys Ala 
    1115                 1120                 1125             


Gln Ile  Trp Ala Phe Tyr Glu  Glu Phe Gln Gln Gly  Phe Gln Glu 
    1130                 1135                 1140             


Met Ala  Asn Glu Asp Trp Ile  Thr Phe Arg Thr Lys  Thr Tyr Leu 
    1145                 1150                 1155             


Phe Glu  Glu Phe Leu Met Asn  Trp His Asp Arg Leu  Arg Lys Val 
    1160                 1165                 1170             


Glu Glu  His Ser Val Met Thr  Val Lys Leu Gln Ser  Glu Val Asp 
    1175                 1180                 1185             


Lys Tyr  Lys Ile Val Ile Pro  Ile Leu Lys Tyr Val  Arg Gly Glu 
    1190                 1195                 1200             


His Leu  Ser Pro Asp His Trp  Leu Asp Leu Phe Arg  Leu Leu Gly 
    1205                 1210                 1215             


Leu Pro  Arg Gly Thr Ser Leu  Glu Lys Leu Leu Phe  Gly Asp Leu 
    1220                 1225                 1230             


Leu Arg  Val Ala Asp Thr Ile  Val Ala Lys Ala Ala  Asp Leu Lys 
    1235                 1240                 1245             


Asp Leu  Asn Ser Arg Ala Gln  Gly Glu Val Thr Ile  Arg Glu Ala 
    1250                 1255                 1260             


Leu Arg  Glu Leu Asp Leu Trp  Gly Val Gly Ala Val  Phe Thr Leu 
    1265                 1270                 1275             


Ile Asp  Tyr Glu Asp Ser Gln  Ser Arg Thr Met Lys  Leu Ile Lys 
    1280                 1285                 1290             


Asp Trp  Lys Asp Ile Val Asn  Gln Val Gly Asp Asn  Arg Cys Leu 
    1295                 1300                 1305             


Leu Gln  Ser Leu Lys Asp Ser  Pro Tyr Tyr Lys Gly  Phe Glu Asp 
    1310                 1315                 1320             


Lys Val  Ser Ile Trp Glu Arg  Lys Leu Ala Glu Leu  Asp Glu Tyr 
    1325                 1330                 1335             


Leu Gln  Asn Leu Asn His Ile  Gln Arg Lys Trp Val  Tyr Leu Glu 
    1340                 1345                 1350             


Pro Ile  Phe Gly Arg Gly Ala  Leu Pro Lys Glu Gln  Thr Arg Phe 
    1355                 1360                 1365             


Asn Arg  Val Asp Glu Asp Phe  Arg Ser Ile Met Thr  Asp Ile Lys 
    1370                 1375                 1380             


Lys Asp  Asn Arg Val Thr Thr  Leu Thr Thr His Ala  Gly Ile Arg 
    1385                 1390                 1395             


Asn Ser  Leu Leu Thr Ile Leu  Asp Gln Leu Gln Arg  Cys Gln Lys 
    1400                 1405                 1410             


Ser Leu  Asn Glu Phe Leu Glu  Glu Lys Arg Ser Ala  Phe Pro Arg 
    1415                 1420                 1425             


Phe Tyr  Phe Ile Gly Asp Asp  Asp Leu Leu Glu Ile  Leu Gly Gln 
    1430                 1435                 1440             


Ser Thr  Asn Pro Ser Val Ile  Gln Ser His Leu Lys  Lys Leu Phe 
    1445                 1450                 1455             


Ala Gly  Ile Asn Ser Val Cys  Phe Asp Glu Lys Ser  Lys His Ile 
    1460                 1465                 1470             


Thr Ala  Met Lys Ser Leu Glu  Gly Glu Val Val Pro  Phe Lys Asn 
    1475                 1480                 1485             


Lys Val  Pro Leu Ser Asn Asn  Val Glu Thr Trp Leu  Asn Asp Leu 
    1490                 1495                 1500             


Ala Leu  Glu Met Lys Lys Thr  Leu Glu Gln Leu Leu  Lys Glu Cys 
    1505                 1510                 1515             


Val Thr  Thr Gly Arg Ser Ser  Gln Gly Ala Val Asp  Pro Ser Leu 
    1520                 1525                 1530             


Phe Pro  Ser Gln Ile Leu Cys  Leu Ala Glu Gln Ile  Lys Phe Thr 
    1535                 1540                 1545             


Glu Asp  Val Glu Asn Ala Ile  Lys Asp His Ser Leu  His Gln Ile 
    1550                 1555                 1560             


Glu Thr  Gln Leu Val Asn Lys  Leu Glu Gln Tyr Thr  Asn Ile Asp 
    1565                 1570                 1575             


Thr Ser  Ser Glu Asp Pro Gly  Asn Thr Glu Ser Gly  Ile Leu Glu 
    1580                 1585                 1590             


Leu Lys  Leu Lys Ala Leu Ile  Leu Asp Ile Ile His  Asn Ile Asp 
    1595                 1600                 1605             


Val Val  Lys Gln Leu Asn Gln  Ile Gln Val His Thr  Thr Glu Asp 
    1610                 1615                 1620             


Trp Ala  Trp Lys Lys Gln Leu  Arg Phe Tyr Met Lys  Ser Asp His 
    1625                 1630                 1635             


Thr Cys  Cys Val Gln Met Val  Asp Ser Glu Phe Gln  Tyr Thr Tyr 
    1640                 1645                 1650             


Glu Tyr  Gln Gly Asn Ala Ser  Lys Leu Val Tyr Thr  Pro Leu Thr 
    1655                 1660                 1665             


Asp Lys  Cys Tyr Leu Thr Leu  Thr Gln Ala Met Lys  Met Gly Leu 
    1670                 1675                 1680             


Gly Gly  Asn Pro Tyr Gly Pro  Ala Gly Thr Gly Lys  Thr Glu Ser 
    1685                 1690                 1695             


Val Lys  Ala Leu Gly Gly Leu  Leu Gly Arg Gln Val  Leu Val Phe 
    1700                 1705                 1710             


Asn Cys  Asp Glu Gly Ile Asp  Val Lys Ser Met Gly  Arg Ile Phe 
    1715                 1720                 1725             


Val Gly  Leu Val Lys Cys Gly  Ala Trp Gly Cys Phe  Asp Glu Phe 
    1730                 1735                 1740             


Asn Arg  Leu Glu Glu Ser Val  Leu Ser Ala Val Ser  Met Gln Ile 
    1745                 1750                 1755             


Gln Thr  Ile Gln Asp Ala Leu  Lys Asn His Arg Thr  Val Cys Glu 
    1760                 1765                 1770             


Leu Leu  Gly Lys Glu Val Glu  Val Asn Ser Asn Ser  Gly Ile Phe 
    1775                 1780                 1785             


Ile Thr  Met Asn Pro Ala Gly  Lys Gly Tyr Gly Gly  Arg Gln Lys 
    1790                 1795                 1800             


Leu Pro  Asp Asn Leu Lys Gln  Leu Phe Arg Pro Val  Ala Met Ser 
    1805                 1810                 1815             


His Pro  Asp Asn Glu Leu Ile  Ala Glu Val Ile Leu  Tyr Ser Glu 
    1820                 1825                 1830             


Gly Phe  Lys Asp Ala Lys Val  Leu Ser Arg Lys Leu  Val Ala Ile 
    1835                 1840                 1845             


Phe Asn  Leu Ser Arg Glu Leu  Leu Thr Pro Gln Gln  His Tyr Asp 
    1850                 1855                 1860             


Trp Gly  Leu Arg Ala Leu Lys  Thr Val Leu Arg Gly  Ser Gly Asn 
    1865                 1870                 1875             


Leu Leu  Arg Gln Leu Asn Lys  Ser Gly Thr Thr Gln  Asn Ala Asn 
    1880                 1885                 1890             


Glu Ser  His Ile Val Val Gln  Ala Leu Arg Leu Asn  Thr Met Ser 
    1895                 1900                 1905             


Lys Phe  Thr Phe Thr Asp Cys  Thr Arg Phe Asp Ala  Leu Ile Lys 
    1910                 1915                 1920             


Asp Val  Phe Pro Gly Ile Glu  Leu Lys Glu Val Glu  Tyr Asp Glu 
    1925                 1930                 1935             


Leu Ser  Ala Ala Leu Lys Gln  Val Phe Glu Glu Ala  Asn Tyr Glu 
    1940                 1945                 1950             


Ile Ile  Pro Asn Gln Ile Lys  Lys Ala Leu Glu Leu  Tyr Glu Gln 
    1955                 1960                 1965             


Leu Cys  Gln Arg Met Gly Val  Val Ile Val Gly Pro  Ser Gly Ala 
    1970                 1975                 1980             


Gly Lys  Ser Thr Leu Trp Arg  Met Leu Arg Ala Ala  Leu Cys Lys 
    1985                 1990                 1995             


Thr Gly  Lys Val Val Lys Gln  Tyr Thr Met Asn Pro  Lys Ala Met 
    2000                 2005                 2010             


Pro Arg  Tyr Gln Leu Leu Gly  His Ile Asp Met Asp  Thr Arg Glu 
    2015                 2020                 2025             


Trp Ser  Asp Gly Val Leu Thr  Asn Ser Ala Arg Gln  Val Val Arg 
    2030                 2035                 2040             


Glu Pro  Gln Asp Val Ser Ser  Trp Ile Ile Cys Asp  Gly Asp Ile 
    2045                 2050                 2055             


Asp Pro  Glu Trp Ile Glu Ser  Leu Asn Ser Val Leu  Asp Asp Asn 
    2060                 2065                 2070             


Arg Leu  Leu Thr Met Pro Ser  Gly Glu Arg Ile Gln  Phe Gly Pro 
    2075                 2080                 2085             


Asn Val  Asn Phe Val Phe Glu  Thr His Asp Leu Ser  Cys Ala Ser 
    2090                 2095                 2100             


Pro Ala  Thr Ile Ser Arg Met  Gly Met Ile Phe Leu  Ser Asp Glu 
    2105                 2110                 2115             


Glu Thr  Asp Leu Asn Ser Leu  Ile Lys Ser Trp Leu  Arg Asn Gln 
    2120                 2125                 2130             


Pro Ala  Glu Tyr Arg Asn Asn  Leu Glu Asn Trp Ile  Gly Asp Tyr 
    2135                 2140                 2145             


Phe Glu  Lys Ala Leu Gln Trp  Val Leu Lys Gln Asn  Asp Tyr Val 
    2150                 2155                 2160             


Val Glu  Thr Ser Leu Val Gly  Thr Val Met Asn Gly  Leu Ser His 
    2165                 2170                 2175             


Leu His  Gly Cys Arg Asp His  Asp Glu Phe Ile Ile  Asn Leu Ile 
    2180                 2185                 2190             


Arg Gly  Leu Gly Gly Asn Leu  Asn Met Lys Ser Arg  Leu Glu Phe 
    2195                 2200                 2205             


Thr Lys  Glu Val Phe His Trp  Ala Arg Glu Ser Pro  Pro Asp Phe 
    2210                 2215                 2220             


His Lys  Pro Met Asp Thr Tyr  Tyr Asp Ser Thr Arg  Gly Arg Leu 
    2225                 2230                 2235             


Ala Thr  Tyr Val Leu Lys Lys  Pro Glu Asp Leu Thr  Ala Asp Asp 
    2240                 2245                 2250             


Phe Ser  Asn Gly Leu Thr Leu  Pro Val Ile Gln Thr  Pro Asp Met 
    2255                 2260                 2265             


Gln Arg  Gly Leu Asp Tyr Phe  Lys Pro Trp Leu Ser  Ser Asp Thr 
    2270                 2275                 2280             


Lys Gln  Pro Phe Ile Leu Val  Gly Pro Glu Gly Cys  Gly Lys Gly 
    2285                 2290                 2295             


Met Leu  Leu Arg Tyr Ala Phe  Ser Gln Leu Arg Ser  Thr Gln Ile 
    2300                 2305                 2310             


Ala Thr  Val His Cys Ser Ala  Gln Thr Thr Ser Arg  His Leu Leu 
    2315                 2320                 2325             


Gln Lys  Leu Ser Gln Thr Cys  Met Val Ile Ser Thr  Asn Thr Gly 
    2330                 2335                 2340             


Arg Val  Tyr Arg Pro Lys Asp  Cys Glu Arg Leu Val  Leu Tyr Leu 
    2345                 2350                 2355             


Lys Asp  Ile Asn Leu Pro Lys  Leu Asp Lys Trp Gly  Thr Ser Thr 
    2360                 2365                 2370             


Leu Val  Ala Phe Leu Gln Gln  Val Leu Thr Tyr Gln  Gly Phe Tyr 
    2375                 2380                 2385             


Asp Glu  Asn Leu Glu Trp Val  Gly Leu Glu Asn Ile  Gln Ile Val 
    2390                 2395                 2400             


Ala Ser  Met Ser Ala Gly Gly  Arg Leu Gly Arg His  Lys Leu Thr 
    2405                 2410                 2415             


Thr Arg  Phe Thr Ser Ile Val  Arg Leu Cys Ser Ile  Asp Tyr Pro 
    2420                 2425                 2430             


Glu Arg  Glu Gln Leu Gln Thr  Ile Tyr Gly Ala Tyr  Leu Glu Pro 
    2435                 2440                 2445             


Val Leu  His Lys Asn Leu Lys  Asn His Ser Ile Trp  Gly Ser Ser 
    2450                 2455                 2460             


Ser Lys  Ile Tyr Leu Leu Ala  Gly Ser Met Val Gln  Val Tyr Glu 
    2465                 2470                 2475             


Gln Val  Arg Ala Lys Phe Thr  Val Asp Asp Tyr Ser  His Tyr Phe 
    2480                 2485                 2490             


Phe Thr  Pro Cys Ile Leu Thr  Gln Trp Val Leu Gly  Leu Phe Arg 
    2495                 2500                 2505             


Tyr Asp  Leu Glu Gly Gly Ser  Ser Asn His Pro Leu  Asp Tyr Val 
    2510                 2515                 2520             


Leu Glu  Ile Val Ala Tyr Glu  Ala Arg Arg Leu Phe  Arg Asp Lys 
    2525                 2530                 2535             


Ile Val  Gly Ala Lys Glu Leu  His Leu Phe Asp Ile  Ile Leu Thr 
    2540                 2545                 2550             


Ser Val  Phe Gln Gly Asp Trp  Gly Ser Asp Ile Leu  Asp Asn Met 
    2555                 2560                 2565             


Ser Asp  Ser Phe Tyr Val Thr  Trp Gly Ala Arg His  Asn Ser Gly 
    2570                 2575                 2580             


Ala Arg  Ala Ala Pro Gly Gln  Pro Leu Pro Pro His  Gly Lys Pro 
    2585                 2590                 2595             


Leu Gly  Lys Leu Asn Ser Thr  Asp Leu Lys Asp Val  Ile Lys Lys 
    2600                 2605                 2610             


Gly Leu  Ile His Tyr Gly Arg  Asp Asn Gln Asn Leu  Asp Ile Leu 
    2615                 2620                 2625             


Leu Phe  His Glu Val Leu Glu  Tyr Met Ser Arg Ile  Asp Arg Val 
    2630                 2635                 2640             


Leu Ser  Phe Pro Gly Gly Ser  Leu Leu Leu Ala Gly  Arg Ser Gly 
    2645                 2650                 2655             


Val Gly  Arg Arg Thr Ile Thr  Ser Leu Val Ser His  Met His Gly 
    2660                 2665                 2670             


Ala Val  Leu Phe Ser Pro Lys  Ile Ser Arg Gly Tyr  Glu Leu Lys 
    2675                 2680                 2685             


Gln Phe  Lys Asn Asp Leu Lys  His Val Leu Gln Leu  Ala Gly Ile 
    2690                 2695                 2700             


Glu Ala  Gln Gln Val Val Leu  Leu Leu Glu Asp Tyr  Gln Phe Val 
    2705                 2710                 2715             


His Pro  Thr Phe Leu Glu Met  Ile Asn Ser Leu Leu  Ser Ser Gly 
    2720                 2725                 2730             


Glu Val  Pro Gly Leu Tyr Thr  Leu Glu Glu Leu Glu  Pro Leu Leu 
    2735                 2740                 2745             


Leu Pro  Leu Lys Asp Gln Ala  Ser Gln Asp Gly Phe  Phe Gly Pro 
    2750                 2755                 2760             


Val Phe  Asn Tyr Phe Thr Tyr  Arg Ile Gln Gln Asn  Leu His Ile 
    2765                 2770                 2775             


Val Leu  Ile Met Asp Ser Ala  Asn Ser Asn Phe Met  Ile Asn Cys 
    2780                 2785                 2790             


Glu Ser  Asn Pro Ala Leu His  Lys Lys Cys Gln Val  Leu Trp Met 
    2795                 2800                 2805             


Glu Gly  Trp Ser Asn Ser Ser  Met Lys Lys Ile Pro  Glu Met Leu 
    2810                 2815                 2820             


Phe Ser  Glu Thr Gly Gly Gly  Glu Lys Tyr Asn Asp  Lys Lys Arg 
    2825                 2830                 2835             


Lys Glu  Glu Lys Lys Lys Asn  Ser Val Asp Pro Asp  Phe Leu Lys 
    2840                 2845                 2850             


Ser Phe  Leu Leu Ile His Glu  Ser Cys Lys Ala Tyr  Gly Ala Thr 
    2855                 2860                 2865             


Pro Ser  Arg Tyr Met Thr Phe  Leu His Val Tyr Ser  Ala Ile Ser 
    2870                 2875                 2880             


Ser Ser  Lys Lys Lys Glu Leu  Leu Lys Arg Gln Ser  His Leu Gln 
    2885                 2890                 2895             


Ala Gly  Val Ser Lys Leu Asn  Glu Ala Lys Ala Leu  Val Asp Glu 
    2900                 2905                 2910             


Leu Asn  Arg Lys Ala Gly Glu  Gln Ser Val Leu Leu  Lys Thr Lys 
    2915                 2920                 2925             


Gln Asp  Glu Ala Asp Ala Ala  Leu Gln Met Ile Thr  Val Ser Met 
    2930                 2935                 2940             


Gln Asp  Ala Ser Glu Gln Lys  Thr Glu Leu Glu Arg  Leu Lys His 
    2945                 2950                 2955             


Arg Ile  Ala Glu Glu Val Val  Lys Ile Glu Glu Arg  Lys Asn Lys 
    2960                 2965                 2970             


Ile Asp  Asp Glu Leu Lys Glu  Val Gln Pro Leu Val  Asn Glu Ala 
    2975                 2980                 2985             


Lys Leu  Ala Val Gly Asn Ile  Lys Pro Glu Ser Leu  Ser Glu Ile 
    2990                 2995                 3000             


Arg Ser  Leu Arg Met Pro Pro  Asp Val Ile Arg Asp  Ile Leu Glu 
    3005                 3010                 3015             


Gly Val  Leu Arg Leu Met Gly  Ile Phe Asp Thr Ser  Trp Val Ser 
    3020                 3025                 3030             


Met Lys  Ser Phe Leu Ala Lys  Arg Gly Val Arg Glu  Asp Ile Ala 
    3035                 3040                 3045             


Thr Phe  Asp Ala Arg Asn Ile  Ser Lys Glu Ile Arg  Glu Ser Val 
    3050                 3055                 3060             


Glu Glu  Leu Leu Phe Lys Asn  Lys Gly Ser Phe Asp  Pro Lys Asn 
    3065                 3070                 3075             


Ala Lys  Arg Ala Ser Thr Ala  Ala Ala Pro Leu Ala  Ala Trp Val 
    3080                 3085                 3090             


Lys Ala  Asn Ile Gln Tyr Ser  His Val Leu Glu Arg  Ile His Pro 
    3095                 3100                 3105             


Leu Glu  Thr Glu Gln Ala Gly  Leu Glu Ser Asn Leu  Lys Lys Thr 
    3110                 3115                 3120             


Glu Asp  Arg Lys Arg Lys Leu  Glu Glu Leu Leu Asn  Ser Val Gly 
    3125                 3130                 3135             


Gln Lys  Val Ser Glu Leu Lys  Glu Lys Phe Gln Ser  Arg Thr Ser 
    3140                 3145                 3150             


Glu Ala  Ala Lys Leu Glu Ala  Glu Val Ser Lys Ala  Gln Glu Thr 
    3155                 3160                 3165             


Ile Lys  Ala Ala Glu Val Leu  Ile Asn Gln Leu Asp  Arg Glu His 
    3170                 3175                 3180             


Lys Arg  Trp Asn Ala Gln Val  Val Glu Ile Thr Glu  Glu Leu Ala 
    3185                 3190                 3195             


Thr Leu  Pro Lys Arg Ala Gln  Leu Ala Ala Ala Phe  Ile Thr Tyr 
    3200                 3205                 3210             


Leu Ser  Ala Ala Pro Glu Ser  Leu Arg Lys Thr Cys  Leu Glu Glu 
    3215                 3220                 3225             


Trp Thr  Lys Ser Ala Gly Leu  Glu Lys Phe Asp Leu  Arg Arg Phe 
    3230                 3235                 3240             


Leu Cys  Thr Glu Ser Glu Gln  Leu Ile Trp Lys Ser  Glu Gly Leu 
    3245                 3250                 3255             


Pro Ser  Asp Asp Leu Ser Ile  Glu Asn Ala Leu Val  Ile Leu Gln 
    3260                 3265                 3270             


Ile Ile  Gly Leu Lys Ser Trp  Ser Arg Val Cys Pro  Phe Leu Ile 
    3275                 3280                 3285             


Asp Pro  Ser Ser Gln Ala Thr  Glu Trp Leu Lys Thr  His Leu Lys 
    3290                 3295                 3300             


Asp Ser  Arg Leu Glu Val Ile  Asn Gln Gln Asp Ser  Asn Phe Ile 
    3305                 3310                 3315             


Thr Ala  Leu Glu Leu Ala Val  Arg Phe Gly Lys Thr  Leu Ile Ile 
    3320                 3325                 3330             


Gln Glu  Met Asp Gly Val Glu  Pro Val Leu Tyr Pro  Leu Leu Arg 
    3335                 3340                 3345             


Arg Asp  Leu Val Ala Gln Gly  Pro Arg Tyr Val Val  Gln Ile Gly 
    3350                 3355                 3360             


Asp Lys  Ile Ile Asp Tyr Asn  Glu Glu Phe Arg Leu  Phe Leu Ser 
    3365                 3370                 3375             


Thr Arg  Asn Pro Asn Pro Phe  Ile Pro Pro Asp Ala  Ala Ser Ile 
    3380                 3385                 3390             


Val Thr  Glu Val Asn Phe Thr  Thr Thr Arg Ser Gly  Leu Arg Gly 
    3395                 3400                 3405             


Gln Leu  Leu Ala Leu Thr Ile  Gln His Glu Lys Pro  Asp Leu Glu 
    3410                 3415                 3420             


Glu Gln  Lys Thr Lys Leu Leu  Gln Gln Glu Glu Asp  Lys Lys Ile 
    3425                 3430                 3435             


Gln Leu  Ala Lys Leu Glu Glu  Ser Leu Leu Glu Thr  Leu Ala Thr 
    3440                 3445                 3450             


Ser Gln  Gly Asn Ile Leu Glu  Asn Lys Asp Leu Ile  Glu Ser Leu 
    3455                 3460                 3465             


Asn Gln  Thr Lys Ala Ser Ser  Ala Leu Ile Gln Glu  Ser Leu Lys 
    3470                 3475                 3480             


Glu Ser  Tyr Lys Leu Gln Ile  Ser Leu Asp Gln Glu  Arg Asp Ala 
    3485                 3490                 3495             


Tyr Leu  Pro Leu Ala Glu Ser  Ala Ser Lys Met Tyr  Phe Ile Ile 
    3500                 3505                 3510             


Ser Asp  Leu Ser Lys Ile Asn  Asn Met Tyr Arg Phe  Ser Leu Ala 
    3515                 3520                 3525             


Ala Phe  Leu Arg Leu Phe Gln  Arg Ala Leu Gln Asn  Lys Gln Asp 
    3530                 3535                 3540             


Ser Glu  Asn Thr Glu Gln Arg  Ile Gln Ser Leu Ile  Ser Ser Leu 
    3545                 3550                 3555             


Gln His  Met Val Tyr Glu Tyr  Ile Cys Arg Cys Leu  Phe Lys Ala 
    3560                 3565                 3570             


Asp Gln  Leu Met Phe Ala Leu  His Phe Val Arg Gly  Met His Pro 
    3575                 3580                 3585             


Glu Leu  Phe Gln Glu Asn Glu  Trp Asp Thr Phe Thr  Gly Val Val 
    3590                 3595                 3600             


Val Gly  Asp Met Leu Arg Lys  Ala Asp Ser Gln Gln  Lys Ile Arg 
    3605                 3610                 3615             


Asp Gln  Leu Pro Ser Trp Ile  Asp Gln Glu Arg Ser  Trp Ala Val 
    3620                 3625                 3630             


Ala Thr  Leu Lys Ile Ala Leu  Pro Ser Leu Tyr Gln  Thr Leu Cys 
    3635                 3640                 3645             


Phe Glu  Asp Ala Ala Leu Trp  Arg Thr Tyr Tyr Asn  Asn Ser Met 
    3650                 3655                 3660             


Cys Glu  Gln Glu Phe Pro Ser  Ile Leu Ala Lys Lys  Val Ser Leu 
    3665                 3670                 3675             


Phe Gln  Gln Ile Leu Val Val  Gln Ala Leu Arg Pro  Asp Arg Leu 
    3680                 3685                 3690             


Gln Ser  Ala Met Ala Leu Phe  Ala Cys Lys Thr Leu  Gly Leu Lys 
    3695                 3700                 3705             


Glu Val  Ser Pro Leu Pro Leu  Asn Leu Lys Arg Leu  Tyr Lys Glu 
    3710                 3715                 3720             


Thr Leu  Glu Ile Glu Pro Ile  Leu Ile Ile Ile Ser  Pro Gly Ala 
    3725                 3730                 3735             


Asp Pro  Ser Gln Glu Leu Gln  Glu Leu Ala Asn Ala  Glu Arg Ser 
    3740                 3745                 3750             


Gly Glu  Cys Tyr His Gln Val  Ala Met Gly Gln Gly  Gln Ala Asp 
    3755                 3760                 3765             


Leu Ala  Ile Gln Met Leu Lys  Glu Cys Ala Arg Asn  Gly Asp Trp 
    3770                 3775                 3780             


Leu Cys  Leu Lys Asn Leu His  Leu Val Val Ser Trp  Leu Pro Val 
    3785                 3790                 3795             


Leu Glu  Lys Glu Leu Asn Thr  Leu Gln Pro Lys Asp  Thr Phe Arg 
    3800                 3805                 3810             


Leu Trp  Leu Thr Ala Glu Val  His Pro Asn Phe Thr  Pro Ile Leu 
    3815                 3820                 3825             


Leu Gln  Ser Ser Leu Lys Ile  Thr Tyr Glu Ser Pro  Pro Gly Leu 
    3830                 3835                 3840             


Lys Lys  Asn Leu Met Arg Thr  Tyr Glu Ser Trp Thr  Pro Glu Gln 
    3845                 3850                 3855             


Ile Ser  Lys Lys Asp Asn Thr  His Arg Ala His Ala  Leu Phe Ser 
    3860                 3865                 3870             


Leu Ala  Trp Phe His Ala Ala  Cys Gln Glu Arg Arg  Asn Tyr Ile 
    3875                 3880                 3885             


Pro Gln  Gly Trp Thr Lys Phe  Tyr Glu Phe Ser Leu  Ser Asp Leu 
    3890                 3895                 3900             


Arg Ala  Gly Tyr Asn Ile Ile  Asp Arg Leu Phe Asp  Gly Ala Lys 
    3905                 3910                 3915             


Asp Val  Gln Trp Glu Phe Val  His Gly Leu Leu Glu  Asn Ala Ile 
    3920                 3925                 3930             


Tyr Gly  Gly Arg Ile Asp Asn  Tyr Phe Asp Leu Arg  Val Leu Gln 
    3935                 3940                 3945             


Ser Tyr  Leu Lys Gln Phe Phe  Asn Ser Ser Val Ile  Asp Val Phe 
    3950                 3955                 3960             


Asn Gln  Arg Asn Lys Lys Ser  Ile Phe Pro Tyr Ser  Val Ser Leu 
    3965                 3970                 3975             


Pro Gln  Ser Cys Ser Ile Leu  Asp Tyr Arg Ala Val  Ile Glu Lys 
    3980                 3985                 3990             


Ile Pro  Glu Asp Asp Lys Pro  Ser Phe Phe Gly Leu  Pro Ala Asn 
    3995                 4000                 4005             


Ile Ala  Arg Ser Ser Gln Arg  Met Ile Ser Ser Gln  Val Ile Ser 
    4010                 4015                 4020             


Gln Leu  Arg Ile Leu Gly Arg  Ser Ile Thr Ala Gly  Ser Lys Phe 
    4025                 4030                 4035             


Asp Arg  Glu Ile Trp Ser Asn  Glu Leu Ser Pro Val  Leu Asn Leu 
    4040                 4045                 4050             


Trp Lys  Lys Leu Asn Gln Asn  Ser Asn Leu Ile His  Gln Lys Val 
    4055                 4060                 4065             


Pro Pro  Pro Asn Asp Arg Gln  Gly Ser Pro Ile Leu  Ser Phe Ile 
    4070                 4075                 4080             


Ile Leu  Glu Gln Phe Asn Ala  Ile Arg Leu Val Gln  Ser Val His 
    4085                 4090                 4095             


Gln Ser  Leu Ala Ala Leu Ser  Lys Val Ile Arg Gly  Thr Thr Leu 
    4100                 4105                 4110             


Leu Ser  Ser Glu Val Gln Lys  Leu Ala Ser Ala Leu  Leu Asn Gln 
    4115                 4120                 4125             


Lys Cys  Pro Leu Ala Trp Gln  Ser Lys Trp Glu Gly  Pro Glu Asp 
    4130                 4135                 4140             


Pro Leu  Gln Tyr Leu Arg Gly  Leu Val Ala Arg Ala  Leu Ala Ile 
    4145                 4150                 4155             


Gln Asn  Trp Val Asp Lys Ala  Glu Lys Gln Ala Leu  Leu Ser Glu 
    4160                 4165                 4170             


Thr Leu  Asp Leu Ser Glu Leu  Phe His Pro Asp Thr  Phe Leu Asn 
    4175                 4180                 4185             


Ala Leu  Arg Gln Glu Thr Ala  Arg Ala Val Gly Arg  Ser Val Asp 
    4190                 4195                 4200             


Ser Leu  Lys Phe Val Ala Ser  Trp Lys Gly Arg Leu  Gln Glu Ala 
    4205                 4210                 4215             


Lys Leu  Gln Ile Lys Ile Ser  Gly Leu Leu Leu Glu  Gly Cys Ser 
    4220                 4225                 4230             


Phe Asp  Gly Asn Gln Leu Ser  Glu Asn Gln Leu Asp  Ser Pro Ser 
    4235                 4240                 4245             


Val Ser  Ser Val Leu Pro Cys  Phe Met Gly Trp Ile  Pro Gln Asp 
    4250                 4255                 4260             


Ala Cys  Gly Pro Tyr Ser Pro  Asp Glu Cys Ile Ser  Leu Pro Val 
    4265                 4270                 4275             


Tyr Thr  Ser Ala Glu Arg Asp  Arg Val Val Thr Asn  Ile Asp Val 
    4280                 4285                 4290             


Pro Cys  Gly Gly Asn Gln Asp  Gln Trp Ile Gln Cys  Gly Ala Ala 
    4295                 4300                 4305             


Leu Phe  Leu Lys Asn Gln 
    4310                 


<210>  3338
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNLL1__Homo_sapiens__NP_001032584

<400>  3338

Met Cys Asp Arg Lys Ala Val Ile Lys Asn Ala Asp Met Ser Glu Glu 
1               5                   10                  15      


Met Gln Gln Asp Ser Val Glu Cys Ala Thr Gln Ala Leu Glu Lys Tyr 
            20                  25                  30          


Asn Ile Glu Lys Asp Ile Ala Ala His Ile Lys Lys Glu Phe Asp Lys 
        35                  40                  45              


Lys Tyr Asn Pro Thr Trp His Cys Ile Val Gly Arg Asn Phe Gly Ser 
    50                  55                  60                  


Tyr Val Thr His Glu Thr Lys His Phe Ile Tyr Phe Tyr Leu Gly Gln 
65                  70                  75                  80  


Val Ala Ile Leu Leu Phe Lys Ser Gly 
                85                  


<210>  3339
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNLL2__Homo_sapiens__NP_542408

<400>  3339

Met Ser Asp Arg Lys Ala Val Ile Lys Asn Ala Asp Met Ser Glu Asp 
1               5                   10                  15      


Met Gln Gln Asp Ala Val Asp Cys Ala Thr Gln Ala Met Glu Lys Tyr 
            20                  25                  30          


Asn Ile Glu Lys Asp Ile Ala Ala Tyr Ile Lys Lys Glu Phe Asp Lys 
        35                  40                  45              


Lys Tyr Asn Pro Thr Trp His Cys Ile Val Gly Arg Asn Phe Gly Ser 
    50                  55                  60                  


Tyr Val Thr His Glu Thr Lys His Phe Ile Tyr Phe Tyr Leu Gly Gln 
65                  70                  75                  80  


Val Ala Ile Leu Leu Phe Lys Ser Gly 
                85                  


<210>  3340
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNLRB1__Homo_sapiens__NP_001268658

<400>  3340

Met Asn Ser Gln Arg Arg Gly Pro His Ser Cys Leu Lys Thr Ala Pro 
1               5                   10                  15      


Lys Ala Lys Pro Phe His Trp Glu Ala Leu Ala Ala Tyr Leu Leu Asp 
            20                  25                  30          


Thr Ser Ile Pro Ile Lys Ser Thr Met Asp Asn Pro Thr Thr Thr Gln 
        35                  40                  45              


Tyr Ala Ser Leu Met His Ser Phe Ile Leu Lys Ala Arg Ser Thr Val 
    50                  55                  60                  


Arg Asp Ile Asp Pro Gln Asn Asp Leu Thr Phe Leu Arg Ile Arg Ser 
65                  70                  75                  80  


Lys Lys Asn Glu Ile Met Val Ala Pro Asp Lys Asp Tyr Phe Leu Ile 
                85                  90                  95      


Val Ile Gln Asn Pro Thr Glu 
            100             


<210>  3341
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNLT1__Homo_sapiens__NP_001278531

<400>  3341

Met Glu Asp Tyr Gln Ala Ala Glu Glu Ala Ile Glu Ser Ala Ile Gly 
1               5                   10                  15      


Gly Asn Ala Tyr Gln His Ser Lys Val Asn Gln Trp Thr Thr Asn Val 
            20                  25                  30          


Val Glu Gln Thr Leu Ser Gln Leu Thr Lys Leu Gly Lys Pro Phe Lys 
        35                  40                  45              


Tyr Ile Val Thr Cys Val Ile Met Gln Lys Asn Gly Ala Gly Leu His 
    50                  55                  60                  


Thr Ala Ser Ser Cys Phe Trp Asp Ser Ser Thr Asp Gly Ser Cys Thr 
65                  70                  75                  80  


Val Arg Trp Glu Asn Lys Thr Met Tyr Cys Ile Val Ser Ala Phe Gly 
                85                  90                  95      


Leu Ser Ile 
            


<210>  3342
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYNLT3__Homo_sapiens__NP_006511

<400>  3342

Met Glu Glu Tyr His Arg His Cys Asp Glu Val Gly Phe Asn Ala Glu 
1               5                   10                  15      


Glu Ala His Asn Ile Val Lys Glu Cys Val Asp Gly Val Leu Gly Gly 
            20                  25                  30          


Glu Asp Tyr Asn His Asn Asn Ile Asn Gln Trp Thr Ala Ser Ile Val 
        35                  40                  45              


Glu Gln Ser Leu Thr His Leu Val Lys Leu Gly Lys Ala Tyr Lys Tyr 
    50                  55                  60                  


Ile Val Thr Cys Ala Val Val Gln Lys Ser Ala Tyr Gly Phe His Thr 
65                  70                  75                  80  


Ala Ser Ser Cys Phe Trp Asp Thr Thr Ser Asp Gly Thr Cys Thr Val 
                85                  90                  95      


Arg Trp Glu Asn Arg Thr Met Asn Cys Ile Val Asn Val Phe Ala Ile 
            100                 105                 110         


Ala Ile Val Leu 
        115     


<210>  3343
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYRK1A__Homo_sapiens__NP_001387

<400>  3343

Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Gly Ser Ser Gly Thr Ser Asn Ser Gly Arg Ala Arg 
        515                 520                 525             


Ser Asp Pro Thr His Gln His Arg His Ser Gly Gly His Phe Thr Ala 
    530                 535                 540                 


Ala Val Gln Ala Met Asp Cys Glu Thr His Ser Pro Gln Val Arg Gln 
545                 550                 555                 560 


Gln Phe Pro Ala Pro Leu Gly Trp Ser Gly Thr Glu Ala Pro Thr Gln 
                565                 570                 575     


Val Thr Val Glu Thr His Pro Val Gln Glu Thr Thr Phe His Val Ala 
            580                 585                 590         


Pro Gln Gln Asn Ala Leu His His His His Gly Asn Ser Ser His His 
        595                 600                 605             


His His His His His His His His His His His Gly Gln Gln Ala Leu 
    610                 615                 620                 


Gly Asn Arg Thr Arg Pro Arg Val Tyr Asn Ser Pro Thr Asn Ser Ser 
625                 630                 635                 640 


Ser Thr Gln Asp Ser Met Glu Val Gly His Ser His His Ser Met Thr 
                645                 650                 655     


Ser Leu Ser Ser Ser Thr Thr Ser Ser Ser Thr Ser Ser Ser Ser Thr 
            660                 665                 670         


Gly Asn Gln Gly Asn Gln Ala Tyr Gln Asn Arg Pro Val Ala Ala Asn 
        675                 680                 685             


Thr Leu Asp Phe Gly Gln Asn Gly Ala Met Asp Val Asn Leu Thr Val 
    690                 695                 700                 


Tyr Ser Asn Pro Arg Gln Glu Thr Gly Ile Ala Gly His Pro Thr Tyr 
705                 710                 715                 720 


Gln Phe Ser Ala Asn Thr Gly Pro Ala His Tyr Met Thr Glu Gly His 
                725                 730                 735     


Leu Thr Met Arg Gln Gly Ala Asp Arg Glu Glu Ser Pro Met Thr Gly 
            740                 745                 750         


Val Cys Val Gln Gln Ser Pro Val Ala Ser Ser 
        755                 760             


<210>  3344
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYRK1B__Homo_sapiens__NP_004705

<400>  3344

Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro 
1               5                   10                  15      


Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg 
            20                  25                  30          


Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu 
        35                  40                  45              


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
    50                  55                  60                  


Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser 
65                  70                  75                  80  


Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn 
                85                  90                  95      


His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu 
            100                 105                 110         


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
        115                 120                 125             


Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn 
    130                 135                 140                 


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu 
145                 150                 155                 160 


Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
                165                 170                 175     


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu 
            180                 185                 190         


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly 
        195                 200                 205             


Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala 
    210                 215                 220                 


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
225                 230                 235                 240 


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
                245                 250                 255     


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
            260                 265                 270         


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr 
        275                 280                 285             


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
    290                 295                 300                 


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp 
305                 310                 315                 320 


Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met 
                325                 330                 335     


Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly 
            340                 345                 350         


Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Tyr Gln 
        355                 360                 365             


Gly Pro Gly Thr Arg Arg Leu Gln Glu Val Leu Gly Val Gln Thr Gly 
    370                 375                 380                 


Gly Pro Gly Gly Arg Arg Ala Gly Glu Pro Gly His Ser Pro Ala Asp 
385                 390                 395                 400 


Tyr Leu Arg Phe Gln Asp Leu Val Leu Arg Met Leu Glu Tyr Glu Pro 
                405                 410                 415     


Ala Ala Arg Ile Ser Pro Leu Gly Ala Leu Gln His Gly Phe Phe Arg 
            420                 425                 430         


Arg Thr Ala Asp Glu Ala Thr Asn Thr Gly Pro Ala Gly Ser Ser Ala 
        435                 440                 445             


Ser Thr Ser Pro Ala Pro Leu Asp Thr Cys Pro Ser Ser Ser Thr Ala 
    450                 455                 460                 


Ser Ser Ile Ser Ser Ser Gly Gly Ser Ser Gly Ser Ser Ser Asp Asn 
465                 470                 475                 480 


Arg Thr Tyr Arg Tyr Ser Asn Arg Tyr Cys Gly Gly Pro Gly Pro Pro 
                485                 490                 495     


Ile Thr Asp Cys Glu Met Asn Ser Pro Gln Val Pro Pro Ser Gln Pro 
            500                 505                 510         


Leu Arg Pro Trp Ala Gly Gly Asp Val Pro His Lys Thr His Gln Ala 
        515                 520                 525             


Pro Ala Ser Ala Ser Ser Leu Pro Gly Thr Gly Ala Gln Leu Pro Pro 
    530                 535                 540                 


Gln Pro Arg Tyr Leu Gly Arg Pro Pro Ser Pro Thr Ser Pro Pro Pro 
545                 550                 555                 560 


Pro Glu Leu Met Asp Val Ser Leu Val Gly Gly Pro Ala Asp Cys Ser 
                565                 570                 575     


Pro Pro His Pro Ala Pro Ala Pro Gln His Pro Ala Ala Ser Ala Leu 
            580                 585                 590         


Arg Thr Arg Met Thr Gly Gly Arg Pro Pro Leu Pro Pro Pro Asp Asp 
        595                 600                 605             


Pro Ala Thr Leu Gly Pro His Leu Gly Leu Arg Gly Val Pro Gln Ser 
    610                 615                 620                 


Thr Ala Ala Ser Ser 
625                 


<210>  3345
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYRK2__Homo_sapiens__NP_003574

<400>  3345

Met Asn Asp His Leu His Val Gly Ser His Ala His Gly Gln Ile Gln 
1               5                   10                  15      


Val Gln Gln Leu Phe Glu Asp Asn Ser Asn Lys Arg Thr Val Leu Thr 
            20                  25                  30          


Thr Gln Pro Asn Gly Leu Thr Thr Val Gly Lys Thr Gly Leu Pro Val 
        35                  40                  45              


Val Pro Glu Arg Gln Leu Asp Ser Ile His Arg Arg Gln Gly Ser Ser 
    50                  55                  60                  


Thr Ser Leu Lys Ser Met Glu Gly Met Gly Lys Val Lys Ala Thr Pro 
65                  70                  75                  80  


Met Thr Pro Glu Gln Ala Met Lys Gln Tyr Met Gln Lys Leu Thr Ala 
                85                  90                  95      


Phe Glu His His Glu Ile Phe Ser Tyr Pro Glu Ile Tyr Phe Leu Gly 
            100                 105                 110         


Leu Asn Ala Lys Lys Arg Gln Gly Met Thr Gly Gly Pro Asn Asn Gly 
        115                 120                 125             


Gly Tyr Asp Asp Asp Gln Gly Ser Tyr Val Gln Val Pro His Asp His 
    130                 135                 140                 


Val Ala Tyr Arg Tyr Glu Val Leu Lys Val Ile Gly Lys Gly Ser Phe 
145                 150                 155                 160 


Gly Gln Val Val Lys Ala Tyr Asp His Lys Val His Gln His Val Ala 
                165                 170                 175     


Leu Lys Met Val Arg Asn Glu Lys Arg Phe His Arg Gln Ala Ala Glu 
            180                 185                 190         


Glu Ile Arg Ile Leu Glu His Leu Arg Lys Gln Asp Lys Asp Asn Thr 
        195                 200                 205             


Met Asn Val Ile His Met Leu Glu Asn Phe Thr Phe Arg Asn His Ile 
    210                 215                 220                 


Cys Met Thr Phe Glu Leu Leu Ser Met Asn Leu Tyr Glu Leu Ile Lys 
225                 230                 235                 240 


Lys Asn Lys Phe Gln Gly Phe Ser Leu Pro Leu Val Arg Lys Phe Ala 
                245                 250                 255     


His Ser Ile Leu Gln Cys Leu Asp Ala Leu His Lys Asn Arg Ile Ile 
            260                 265                 270         


His Cys Asp Leu Lys Pro Glu Asn Ile Leu Leu Lys Gln Gln Gly Arg 
        275                 280                 285             


Ser Gly Ile Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr Glu His Gln 
    290                 295                 300                 


Arg Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ala Pro Glu Val 
305                 310                 315                 320 


Ile Leu Gly Ala Arg Tyr Gly Met Pro Ile Asp Met Trp Ser Leu Gly 
                325                 330                 335     


Cys Ile Leu Ala Glu Leu Leu Thr Gly Tyr Pro Leu Leu Pro Gly Glu 
            340                 345                 350         


Asp Glu Gly Asp Gln Leu Ala Cys Met Ile Glu Leu Leu Gly Met Pro 
        355                 360                 365             


Ser Gln Lys Leu Leu Asp Ala Ser Lys Arg Ala Lys Asn Phe Val Ser 
    370                 375                 380                 


Ser Lys Gly Tyr Pro Arg Tyr Cys Thr Val Thr Thr Leu Ser Asp Gly 
385                 390                 395                 400 


Ser Val Val Leu Asn Gly Gly Arg Ser Arg Arg Gly Lys Leu Arg Gly 
                405                 410                 415     


Pro Pro Glu Ser Arg Glu Trp Gly Asn Ala Leu Lys Gly Cys Asp Asp 
            420                 425                 430         


Pro Leu Phe Leu Asp Phe Leu Lys Gln Cys Leu Glu Trp Asp Pro Ala 
        435                 440                 445             


Val Arg Met Thr Pro Gly Gln Ala Leu Arg His Pro Trp Leu Arg Arg 
    450                 455                 460                 


Arg Leu Pro Lys Pro Pro Thr Gly Glu Lys Thr Ser Val Lys Arg Ile 
465                 470                 475                 480 


Thr Glu Ser Thr Gly Ala Ile Thr Ser Ile Ser Lys Leu Pro Pro Pro 
                485                 490                 495     


Ser Ser Ser Ala Ser Lys Leu Arg Thr Asn Leu Ala Gln Met Thr Asp 
            500                 505                 510         


Ala Asn Gly Asn Ile Gln Gln Arg Thr Val Leu Pro Lys Leu Val Ser 
        515                 520                 525             


<210>  3346
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYRK3__Homo_sapiens__NP_001004023

<400>  3346

Met Lys Trp Lys Glu Lys Leu Gly Asp Gly Val Tyr Asp Thr Phe Met 
1               5                   10                  15      


Met Ile Asp Glu Thr Lys Cys Pro Pro Cys Ser Asn Val Leu Cys Asn 
            20                  25                  30          


Pro Ser Glu Pro Pro Pro Pro Arg Arg Leu Asn Met Thr Thr Glu Gln 
        35                  40                  45              


Phe Thr Gly Asp His Thr Gln His Phe Leu Asp Gly Gly Glu Met Lys 
    50                  55                  60                  


Val Glu Gln Leu Phe Gln Glu Phe Gly Asn Arg Lys Ser Asn Thr Ile 
65                  70                  75                  80  


Gln Ser Asp Gly Ile Ser Asp Ser Glu Lys Cys Ser Pro Thr Val Ser 
                85                  90                  95      


Gln Gly Lys Ser Ser Asp Cys Leu Asn Thr Val Lys Ser Asn Ser Ser 
            100                 105                 110         


Ser Lys Ala Pro Lys Val Val Pro Leu Thr Pro Glu Gln Ala Leu Lys 
        115                 120                 125             


Gln Tyr Lys His His Leu Thr Ala Tyr Glu Lys Leu Glu Ile Ile Asn 
    130                 135                 140                 


Tyr Pro Glu Ile Tyr Phe Val Gly Pro Asn Ala Lys Lys Arg His Gly 
145                 150                 155                 160 


Val Ile Gly Gly Pro Asn Asn Gly Gly Tyr Asp Asp Ala Asp Gly Ala 
                165                 170                 175     


Tyr Ile His Val Pro Arg Asp His Leu Ala Tyr Arg Tyr Glu Val Leu 
            180                 185                 190         


Lys Ile Ile Gly Lys Gly Ser Phe Gly Gln Val Ala Arg Val Tyr Asp 
        195                 200                 205             


His Lys Leu Arg Gln Tyr Val Ala Leu Lys Met Val Arg Asn Glu Lys 
    210                 215                 220                 


Arg Phe His Arg Gln Ala Ala Glu Glu Ile Arg Ile Leu Glu His Leu 
225                 230                 235                 240 


Lys Lys Gln Asp Lys Thr Gly Ser Met Asn Val Ile His Met Leu Glu 
                245                 250                 255     


Ser Phe Thr Phe Arg Asn His Val Cys Met Ala Phe Glu Leu Leu Ser 
            260                 265                 270         


Ile Asp Leu Tyr Glu Leu Ile Lys Lys Asn Lys Phe Gln Gly Phe Ser 
        275                 280                 285             


Val Gln Leu Val Arg Lys Phe Ala Gln Ser Ile Leu Gln Ser Leu Asp 
    290                 295                 300                 


Ala Leu His Lys Asn Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Leu Leu Lys His His Gly Arg Ser Ser Thr Lys Val Ile Asp Phe 
                325                 330                 335     


Gly Ser Ser Cys Phe Glu Tyr Gln Lys Leu Tyr Thr Tyr Ile Gln Ser 
            340                 345                 350         


Arg Phe Tyr Arg Ala Pro Glu Ile Ile Leu Gly Ser Arg Tyr Ser Thr 
        355                 360                 365             


Pro Ile Asp Ile Trp Ser Phe Gly Cys Ile Leu Ala Glu Leu Leu Thr 
    370                 375                 380                 


Gly Gln Pro Leu Phe Pro Gly Glu Asp Glu Gly Asp Gln Leu Ala Cys 
385                 390                 395                 400 


Met Met Glu Leu Leu Gly Met Pro Pro Pro Lys Leu Leu Glu Gln Ser 
                405                 410                 415     


Lys Arg Ala Lys Tyr Phe Ile Asn Ser Lys Gly Ile Pro Arg Tyr Cys 
            420                 425                 430         


Ser Val Thr Thr Gln Ala Asp Gly Arg Val Val Leu Val Gly Gly Arg 
        435                 440                 445             


Ser Arg Arg Gly Lys Lys Arg Gly Pro Pro Gly Ser Lys Asp Trp Gly 
    450                 455                 460                 


Thr Ala Leu Lys Gly Cys Asp Asp Tyr Leu Phe Ile Glu Phe Leu Lys 
465                 470                 475                 480 


Arg Cys Leu His Trp Asp Pro Ser Ala Arg Leu Thr Pro Ala Gln Ala 
                485                 490                 495     


Leu Arg His Pro Trp Ile Ser Lys Ser Val Pro Arg Pro Leu Thr Thr 
            500                 505                 510         


Ile Asp Lys Val Ser Gly Lys Arg Val Val Asn Pro Ala Ser Ala Phe 
        515                 520                 525             


Gln Gly Leu Gly Ser Lys Leu Pro Pro Val Val Gly Ile Ala Asn Lys 
    530                 535                 540                 


Leu Lys Ala Asn Leu Met Ser Glu Thr Asn Gly Ser Ile Pro Leu Cys 
545                 550                 555                 560 


Ser Val Leu Pro Lys Leu Ile Ser 
                565             


<210>  3347
<211>  2081
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYSF__Homo_sapiens__NP_001123927

<400>  3347

Met Leu Cys Cys Leu Leu Val Arg Ala Ser Asn Leu Pro Ser Ala Lys 
1               5                   10                  15      


Lys Asp Arg Arg Ser Asp Pro Val Ala Ser Leu Thr Phe Arg Gly Val 
            20                  25                  30          


Lys Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn 
        35                  40                  45              


Glu Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser 
    50                  55                  60                  


Glu Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg 
65                  70                  75                  80  


Phe Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro 
                85                  90                  95      


Ser Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln 
            100                 105                 110         


Pro Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro 
        115                 120                 125             


Gly Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro 
    130                 135                 140                 


Thr Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp 
145                 150                 155                 160 


Thr Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp 
                165                 170                 175     


Gln Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser 
            180                 185                 190         


Arg Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro 
        195                 200                 205             


Thr Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg 
    210                 215                 220                 


Val Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro 
225                 230                 235                 240 


Val Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His 
                245                 250                 255     


Lys Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe 
            260                 265                 270         


Asp Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val 
        275                 280                 285             


Asp Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met 
    290                 295                 300                 


Asp Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys 
305                 310                 315                 320 


Trp Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly 
                325                 330                 335     


Tyr Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro 
            340                 345                 350         


Leu Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn 
        355                 360                 365             


Leu Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu 
    370                 375                 380                 


Lys Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met 
385                 390                 395                 400 


Asp Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu 
                405                 410                 415     


Val Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser 
            420                 425                 430         


Lys Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr 
        435                 440                 445             


Leu Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile 
    450                 455                 460                 


Ile Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr 
465                 470                 475                 480 


Leu Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu 
                485                 490                 495     


Pro Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr 
            500                 505                 510         


Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly 
        515                 520                 525             


Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn 
    530                 535                 540                 


Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser 
545                 550                 555                 560 


Leu Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu 
                565                 570                 575     


Pro Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys 
            580                 585                 590         


Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val 
        595                 600                 605             


Asp Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys 
    610                 615                 620                 


Phe Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg 
625                 630                 635                 640 


Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val 
                645                 650                 655     


Lys Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg 
            660                 665                 670         


Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala 
        675                 680                 685             


Gly Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu 
    690                 695                 700                 


Asp Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly 
705                 710                 715                 720 


Cys Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His 
                725                 730                 735     


Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile 
            740                 745                 750         


Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala 
        755                 760                 765             


Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala 
    770                 775                 780                 


Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln 
785                 790                 795                 800 


Gly Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu 
                805                 810                 815     


Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu 
            820                 825                 830         


Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg 
        835                 840                 845             


Met Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp 
    850                 855                 860                 


Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala 
865                 870                 875                 880 


Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly 
                885                 890                 895     


Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile 
            900                 905                 910         


Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala 
        915                 920                 925             


Gly Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp 
    930                 935                 940                 


Ala Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg 
945                 950                 955                 960 


Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val 
                965                 970                 975     


Asn Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly 
            980                 985                 990         


Trp Lys Trp Glu Asp Glu Glu Trp  Ser Thr Asp Leu Asn  Arg Ala Val 
        995                 1000                 1005             


Asp Glu  Gln Gly Trp Glu Tyr  Ser Ile Thr Ile Pro  Pro Glu Arg 
    1010                 1015                 1020             


Lys Pro  Lys His Trp Val Pro  Ala Glu Lys Met Tyr  Tyr Thr His 
    1025                 1030                 1035             


Arg Arg  Arg Arg Trp Val Arg  Leu Arg Arg Arg Asp  Leu Ser Gln 
    1040                 1045                 1050             


Met Glu  Ala Leu Lys Arg His  Arg Gln Ala Glu Ala  Glu Gly Glu 
    1055                 1060                 1065             


Gly Trp  Glu Tyr Ala Ser Leu  Phe Gly Trp Lys Phe  His Leu Glu 
    1070                 1075                 1080             


Tyr Arg  Lys Thr Asp Ala Phe  Arg Arg Arg Arg Trp  Arg Arg Arg 
    1085                 1090                 1095             


Met Glu  Pro Leu Glu Lys Thr  Gly Pro Ala Ala Val  Phe Ala Leu 
    1100                 1105                 1110             


Glu Gly  Ala Leu Gly Gly Val  Met Asp Asp Lys Ser  Glu Asp Ser 
    1115                 1120                 1125             


Met Ser  Val Ser Thr Leu Ser  Phe Gly Val Asn Arg  Pro Thr Ile 
    1130                 1135                 1140             


Ser Cys  Ile Phe Asp Tyr Gly  Asn Arg Tyr His Leu  Arg Cys Tyr 
    1145                 1150                 1155             


Met Tyr  Gln Ala Arg Asp Leu  Ala Ala Met Asp Lys  Asp Ser Phe 
    1160                 1165                 1170             


Ser Asp  Pro Tyr Ala Ile Val  Ser Phe Leu His Gln  Ser Gln Lys 
    1175                 1180                 1185             


Thr Val  Val Val Lys Asn Thr  Leu Asn Pro Thr Trp  Asp Gln Thr 
    1190                 1195                 1200             


Leu Ile  Phe Tyr Glu Ile Glu  Ile Phe Gly Glu Pro  Ala Thr Val 
    1205                 1210                 1215             


Ala Glu  Gln Pro Pro Ser Ile  Val Val Glu Leu Tyr  Asp His Asp 
    1220                 1225                 1230             


Thr Tyr  Gly Ala Asp Glu Phe  Met Gly Arg Cys Ile  Cys Gln Pro 
    1235                 1240                 1245             


Ser Leu  Glu Arg Met Pro Arg  Leu Ala Trp Phe Pro  Leu Thr Arg 
    1250                 1255                 1260             


Gly Ser  Gln Pro Ser Gly Glu  Leu Leu Ala Ser Phe  Glu Leu Ile 
    1265                 1270                 1275             


Gln Arg  Glu Lys Pro Ala Ile  His His Ile Pro Gly  Phe Glu Val 
    1280                 1285                 1290             


Gln Glu  Thr Ser Arg Ile Leu  Asp Glu Ser Glu Asp  Thr Asp Leu 
    1295                 1300                 1305             


Pro Tyr  Pro Pro Pro Gln Arg  Glu Ala Asn Ile Tyr  Met Val Pro 
    1310                 1315                 1320             


Gln Asn  Ile Lys Pro Ala Leu  Gln Arg Thr Ala Ile  Glu Ile Leu 
    1325                 1330                 1335             


Ala Trp  Gly Leu Arg Asn Met  Lys Ser Tyr Gln Leu  Ala Asn Ile 
    1340                 1345                 1350             


Ser Ser  Pro Ser Leu Val Val  Glu Cys Gly Gly Gln  Thr Val Gln 
    1355                 1360                 1365             


Ser Cys  Val Ile Arg Asn Leu  Arg Lys Asn Pro Asn  Phe Asp Ile 
    1370                 1375                 1380             


Cys Thr  Leu Phe Met Glu Val  Met Leu Pro Arg Glu  Glu Leu Tyr 
    1385                 1390                 1395             


Cys Pro  Pro Ile Thr Val Lys  Val Ile Asp Asn Arg  Gln Phe Gly 
    1400                 1405                 1410             


Arg Arg  Pro Val Val Gly Gln  Cys Thr Ile Arg Ser  Leu Glu Ser 
    1415                 1420                 1425             


Phe Leu  Cys Asp Pro Tyr Ser  Ala Glu Ser Pro Ser  Pro Gln Gly 
    1430                 1435                 1440             


Gly Pro  Asp Asp Val Ser Leu  Leu Ser Pro Gly Glu  Asp Val Leu 
    1445                 1450                 1455             


Ile Asp  Ile Asp Asp Lys Glu  Pro Leu Ile Pro Ile  Gln Glu Glu 
    1460                 1465                 1470             


Glu Phe  Ile Asp Trp Trp Ser  Lys Phe Phe Ala Ser  Ile Gly Glu 
    1475                 1480                 1485             


Arg Glu  Lys Cys Gly Ser Tyr  Leu Glu Lys Asp Phe  Asp Thr Leu 
    1490                 1495                 1500             


Lys Val  Tyr Asp Thr Gln Leu  Glu Asn Val Glu Ala  Phe Glu Gly 
    1505                 1510                 1515             


Leu Ser  Asp Phe Cys Asn Thr  Phe Lys Leu Tyr Arg  Gly Lys Thr 
    1520                 1525                 1530             


Gln Glu  Glu Thr Glu Asp Pro  Ser Val Ile Gly Glu  Phe Lys Gly 
    1535                 1540                 1545             


Leu Phe  Lys Ile Tyr Pro Leu  Pro Glu Asp Pro Ala  Ile Pro Met 
    1550                 1555                 1560             


Pro Pro  Arg Gln Phe His Gln  Leu Ala Ala Gln Gly  Pro Gln Glu 
    1565                 1570                 1575             


Cys Leu  Val Arg Ile Tyr Ile  Val Arg Ala Phe Gly  Leu Gln Pro 
    1580                 1585                 1590             


Lys Asp  Pro Asn Gly Lys Cys  Asp Pro Tyr Ile Lys  Ile Ser Ile 
    1595                 1600                 1605             


Gly Lys  Lys Ser Val Ser Asp  Gln Asp Asn Tyr Ile  Pro Cys Thr 
    1610                 1615                 1620             


Leu Glu  Pro Val Phe Gly Lys  Met Phe Glu Leu Thr  Cys Thr Leu 
    1625                 1630                 1635             


Pro Leu  Glu Lys Asp Leu Lys  Ile Thr Leu Tyr Asp  Tyr Asp Leu 
    1640                 1645                 1650             


Leu Ser  Lys Asp Glu Lys Ile  Gly Glu Thr Val Val  Asp Leu Glu 
    1655                 1660                 1665             


Asn Arg  Leu Leu Ser Lys Phe  Gly Ala Arg Cys Gly  Leu Pro Gln 
    1670                 1675                 1680             


Thr Tyr  Cys Val Ser Gly Pro  Asn Gln Trp Arg Asp  Gln Leu Arg 
    1685                 1690                 1695             


Pro Ser  Gln Leu Leu His Leu  Phe Cys Gln Gln His  Arg Val Lys 
    1700                 1705                 1710             


Ala Pro  Val Tyr Arg Thr Asp  Arg Val Met Phe Gln  Asp Lys Glu 
    1715                 1720                 1725             


Tyr Ser  Ile Glu Glu Ile Glu  Ala Gly Arg Ile Pro  Asn Pro His 
    1730                 1735                 1740             


Leu Gly  Pro Val Glu Glu Arg  Leu Ala Leu His Val  Leu Gln Gln 
    1745                 1750                 1755             


Gln Gly  Leu Val Pro Glu His  Val Glu Ser Arg Pro  Leu Tyr Ser 
    1760                 1765                 1770             


Pro Leu  Gln Pro Asp Ile Glu  Gln Gly Lys Leu Gln  Met Trp Val 
    1775                 1780                 1785             


Asp Leu  Phe Pro Lys Ala Leu  Gly Arg Pro Gly Pro  Pro Phe Asn 
    1790                 1795                 1800             


Ile Thr  Pro Arg Arg Ala Arg  Arg Phe Phe Leu Arg  Cys Ile Ile 
    1805                 1810                 1815             


Trp Asn  Thr Arg Asp Val Ile  Leu Asp Asp Leu Ser  Leu Thr Gly 
    1820                 1825                 1830             


Glu Lys  Met Ser Asp Ile Tyr  Val Lys Gly Trp Met  Ile Gly Phe 
    1835                 1840                 1845             


Glu Glu  His Lys Gln Lys Thr  Asp Val His Tyr Arg  Ser Leu Gly 
    1850                 1855                 1860             


Gly Glu  Gly Asn Phe Asn Trp  Arg Phe Ile Phe Pro  Phe Asp Tyr 
    1865                 1870                 1875             


Leu Pro  Ala Glu Gln Val Cys  Thr Ile Ala Lys Lys  Asp Ala Phe 
    1880                 1885                 1890             


Trp Arg  Leu Asp Lys Thr Glu  Ser Lys Ile Pro Ala  Arg Val Val 
    1895                 1900                 1905             


Phe Gln  Ile Trp Asp Asn Asp  Lys Phe Ser Phe Asp  Asp Phe Leu 
    1910                 1915                 1920             


Gly Ser  Leu Gln Leu Asp Leu  Asn Arg Met Pro Lys  Pro Ala Lys 
    1925                 1930                 1935             


Thr Ala  Lys Lys Cys Ser Leu  Asp Gln Leu Asp Asp  Ala Phe His 
    1940                 1945                 1950             


Pro Glu  Trp Phe Val Ser Leu  Phe Glu Gln Lys Thr  Val Lys Gly 
    1955                 1960                 1965             


Trp Trp  Pro Cys Val Ala Glu  Glu Gly Glu Lys Lys  Ile Leu Ala 
    1970                 1975                 1980             


Gly Lys  Leu Glu Met Thr Leu  Glu Ile Val Ala Glu  Ser Glu His 
    1985                 1990                 1995             


Glu Glu  Arg Pro Ala Gly Gln  Gly Arg Asp Glu Pro  Asn Met Asn 
    2000                 2005                 2010             


Pro Lys  Leu Glu Asp Pro Arg  Arg Pro Asp Thr Ser  Phe Leu Trp 
    2015                 2020                 2025             


Phe Thr  Ser Pro Tyr Lys Thr  Met Lys Phe Ile Leu  Trp Arg Arg 
    2030                 2035                 2040             


Phe Arg  Trp Ala Ile Ile Leu  Phe Ile Ile Leu Phe  Ile Leu Leu 
    2045                 2050                 2055             


Leu Phe  Leu Ala Ile Phe Ile  Tyr Ala Phe Pro Asn  Tyr Ala Ala 
    2060                 2065                 2070             


Met Lys  Leu Val Lys Pro Phe  Ser 
    2075                 2080     


<210>  3348
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DYX1C1__Homo_sapiens__NP_001028731

<400>  3348

Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 
1               5                   10                  15      


Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 
            20                  25                  30          


Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 
        35                  40                  45              


Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 
    50                  55                  60                  


Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 
65                  70                  75                  80  


Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 
                85                  90                  95      


Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 
            100                 105                 110         


Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 
        115                 120                 125             


Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 
    130                 135                 140                 


Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu 
145                 150                 155                 160 


Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 
                165                 170                 175     


Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 
            180                 185                 190         


Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 
        195                 200                 205             


Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 
    210                 215                 220                 


Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile 
225                 230                 235                 240 


Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 
                245                 250                 255     


Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 
            260                 265                 270         


Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 
        275                 280                 285             


Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 
    290                 295                 300                 


Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn 
305                 310                 315                 320 


Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 
                325                 330                 335     


Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Tyr Arg 
            340                 345                 350         


Ile Met Lys Arg His Leu Arg Leu Ile His Pro Thr Lys Leu Tyr Lys 
        355                 360                 365             


Leu Met Leu Arg Arg Phe Gly Met 
    370                 375     


<210>  3349
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DZIP1__Homo_sapiens__NP_055749

<400>  3349

Met Gln Ala Glu Ala Ala Asp Trp Phe Ser Ser Met Pro Phe Gln Lys 
1               5                   10                  15      


His Val Tyr Tyr Pro Leu Ala Ser Gly Pro Glu Gly Pro Asp Val Ala 
            20                  25                  30          


Val Ala Ala Ala Ala Ala Gly Ala Ala Ser Met Ala Cys Ala Pro Pro 
        35                  40                  45              


Ser Ala Ala Ser Gly Pro Leu Pro Phe Phe Gln Phe Arg Pro Arg Leu 
    50                  55                  60                  


Glu Ser Val Asp Trp Arg Arg Leu Ser Ala Ile Asp Val Asp Lys Val 
65                  70                  75                  80  


Ala Gly Ala Val Asp Val Leu Thr Leu Gln Glu Asn Ile Met Asn Ile 
                85                  90                  95      


Thr Phe Cys Lys Leu Glu Asp Glu Lys Cys Pro His Cys Gln Ser Gly 
            100                 105                 110         


Val Asp Pro Val Leu Leu Lys Leu Ile Arg Leu Ala Gln Phe Thr Ile 
        115                 120                 125             


Glu Tyr Leu Leu His Ser Gln Glu Phe Leu Thr Ser Gln Leu His Thr 
    130                 135                 140                 


Leu Glu Glu Arg Leu Arg Leu Ser His Cys Asp Gly Glu Gln Ser Lys 
145                 150                 155                 160 


Lys Leu Leu Thr Lys Gln Ala Gly Glu Ile Lys Thr Leu Lys Glu Glu 
                165                 170                 175     


Cys Lys Arg Arg Lys Lys Met Ile Ser Thr Gln Gln Leu Met Ile Glu 
            180                 185                 190         


Ala Lys Ala Asn Tyr Tyr Gln Cys His Phe Cys Asp Lys Ala Phe Met 
        195                 200                 205             


Asn Gln Ala Phe Leu Gln Ser His Ile Gln Arg Arg His Thr Glu Glu 
    210                 215                 220                 


Asn Ser His Phe Glu Tyr Gln Lys Asn Ala Gln Ile Glu Lys Leu Arg 
225                 230                 235                 240 


Ser Glu Ile Val Val Leu Lys Glu Glu Leu Gln Leu Thr Arg Ser Glu 
                245                 250                 255     


Leu Glu Ala Ala His His Ala Ser Ala Val Arg Phe Ser Lys Glu Tyr 
            260                 265                 270         


Glu Met Gln Lys Thr Lys Glu Glu Asp Phe Leu Lys Leu Phe Asp Arg 
        275                 280                 285             


Trp Lys Glu Glu Glu Lys Glu Lys Leu Val Asp Glu Met Glu Lys Val 
    290                 295                 300                 


Lys Glu Met Phe Met Lys Glu Phe Lys Glu Leu Thr Ser Lys Asn Ser 
305                 310                 315                 320 


Ala Leu Glu Tyr Gln Leu Ser Glu Ile Gln Lys Ser Asn Met Gln Ile 
                325                 330                 335     


Lys Ser Asn Ile Gly Thr Leu Lys Asp Ala His Glu Phe Lys Glu Asp 
            340                 345                 350         


Arg Ser Pro Tyr Pro Gln Asp Phe His Asn Val Met Gln Leu Leu Asp 
        355                 360                 365             


Ser Gln Glu Ser Lys Trp Thr Ala Arg Val Gln Ala Ile His Gln Glu 
    370                 375                 380                 


His Lys Lys Glu Lys Gly Arg Leu Leu Ser His Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Thr Ser Met Ile Asp Asp Leu Asn Ala Ser Asn Val Phe Tyr Lys Lys 
                405                 410                 415     


Arg Ile Glu Glu Leu Gly Gln Arg Leu Gln Glu Gln Asn Glu Leu Ile 
            420                 425                 430         


Ile Thr Gln Arg Gln Gln Ile Lys Asp Phe Thr Cys Asn Pro Leu Asn 
        435                 440                 445             


Ser Ile Ser Glu Pro Lys Val Asn Ala Pro Ala Leu His Thr Leu Glu 
    450                 455                 460                 


Thr Lys Ser Ser Leu Pro Met Val His Glu Gln Ala Phe Ser Ser His 
465                 470                 475                 480 


Ile Leu Glu Pro Ile Glu Glu Leu Ser Glu Glu Glu Lys Gly Arg Glu 
                485                 490                 495     


Asn Glu Gln Lys Leu Asn Asn Asn Lys Met His Leu Arg Lys Ala Leu 
            500                 505                 510         


Lys Ser Asn Ser Ser Leu Thr Lys Gly Leu Arg Thr Met Val Glu Gln 
        515                 520                 525             


Asn Leu Met Glu Lys Leu Glu Thr Leu Gly Ile Asn Ala Asp Ile Arg 
    530                 535                 540                 


Gly Ile Ser Ser Asp Gln Leu His Arg Val Leu Lys Ser Val Glu Ser 
545                 550                 555                 560 


Glu Arg His Lys Gln Glu Arg Glu Ile Pro Asn Phe His Gln Ile Arg 
                565                 570                 575     


Glu Phe Leu Glu His Gln Val Ser Cys Lys Ile Glu Glu Lys Ala Leu 
            580                 585                 590         


Leu Ser Ser Asp Gln Cys Ser Val Ser Gln Met Asp Thr Leu Ser Thr 
        595                 600                 605             


Gly Glu Val Pro Lys Met Ile Gln Leu Pro Ser Lys Asn Arg Gln Leu 
    610                 615                 620                 


Ile Arg Gln Lys Ala Val Ser Thr Asp Arg Thr Ser Val Pro Lys Ile 
625                 630                 635                 640 


Lys Lys Asn Val Met Glu Asp Pro Phe Pro Arg Lys Ser Ser Thr Ile 
                645                 650                 655     


Thr Thr Pro Pro Phe Ser Ser Glu Glu Glu Gln Glu Asp Asp Asp Leu 
            660                 665                 670         


Ile Arg Ala Tyr Ala Ser Pro Gly Pro Leu Pro Val Pro Pro Pro Gln 
        675                 680                 685             


Asn Lys Gly Ser Phe Gly Lys Asn Thr Val Lys Ser Asp Ala Asp Gly 
    690                 695                 700                 


Thr Glu Gly Ser Glu Ile Glu Asp Thr Asp Asp Ser Pro Lys Pro Ala 
705                 710                 715                 720 


Gly Val Ala Val Lys Thr Pro Thr Glu Lys Val Glu Lys Met Phe Pro 
                725                 730                 735     


His Arg Lys Asn Val Asn Lys Pro Val Gly Gly Thr Asn Val Pro Glu 
            740                 745                 750         


Met Phe Ile Lys Lys Glu Glu Leu Gln Glu Leu Lys Cys Ala Asp Val 
        755                 760                 765             


Glu Asp Glu Asp Trp Asp Ile Ser Ser Leu Glu Glu Glu Ile Ser Leu 
    770                 775                 780                 


Gly Lys Lys Ser Gly Lys Glu Gln Lys Glu Pro Pro Pro Ala Lys Asn 
785                 790                 795                 800 


Glu Pro His Phe Ala His Val Leu Asn Ala Trp Gly Ala Phe Asn Pro 
                805                 810                 815     


Lys Gly Pro Lys Gly Glu Gly Leu Gln Glu Asn Glu Ser Ser Thr Leu 
            820                 825                 830         


Lys Ser Ser Leu Val Thr Val Thr Asp Trp Ser Asp Thr Ser Asp Val 
        835                 840                 845             


<210>  3350
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2F1__Homo_sapiens__NP_005216

<400>  3350

Met Ala Leu Ala Gly Ala Pro Ala Gly Gly Pro Cys Ala Pro Ala Leu 
1               5                   10                  15      


Glu Ala Leu Leu Gly Ala Gly Ala Leu Arg Leu Leu Asp Ser Ser Gln 
            20                  25                  30          


Ile Val Ile Ile Ser Ala Ala Gln Asp Ala Ser Ala Pro Pro Ala Pro 
        35                  40                  45              


Thr Gly Pro Ala Ala Pro Ala Ala Gly Pro Cys Asp Pro Asp Leu Leu 
    50                  55                  60                  


Leu Phe Ala Thr Pro Gln Ala Pro Arg Pro Thr Pro Ser Ala Pro Arg 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Pro Pro Val Lys Arg Arg Leu Asp Leu Glu Thr 
                85                  90                  95      


Asp His Gln Tyr Leu Ala Glu Ser Ser Gly Pro Ala Arg Gly Arg Gly 
            100                 105                 110         


Arg His Pro Gly Lys Gly Val Lys Ser Pro Gly Glu Lys Ser Arg Tyr 
        115                 120                 125             


Glu Thr Ser Leu Asn Leu Thr Thr Lys Arg Phe Leu Glu Leu Leu Ser 
    130                 135                 140                 


His Ser Ala Asp Gly Val Val Asp Leu Asn Trp Ala Ala Glu Val Leu 
145                 150                 155                 160 


Lys Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val Leu Glu Gly 
                165                 170                 175     


Ile Gln Leu Ile Ala Lys Lys Ser Lys Asn His Ile Gln Trp Leu Gly 
            180                 185                 190         


Ser His Thr Thr Val Gly Val Gly Gly Arg Leu Glu Gly Leu Thr Gln 
        195                 200                 205             


Asp Leu Arg Gln Leu Gln Glu Ser Glu Gln Gln Leu Asp His Leu Met 
    210                 215                 220                 


Asn Ile Cys Thr Thr Gln Leu Arg Leu Leu Ser Glu Asp Thr Asp Ser 
225                 230                 235                 240 


Gln Arg Leu Ala Tyr Val Thr Cys Gln Asp Leu Arg Ser Ile Ala Asp 
                245                 250                 255     


Pro Ala Glu Gln Met Val Met Val Ile Lys Ala Pro Pro Glu Thr Gln 
            260                 265                 270         


Leu Gln Ala Val Asp Ser Ser Glu Asn Phe Gln Ile Ser Leu Lys Ser 
        275                 280                 285             


Lys Gln Gly Pro Ile Asp Val Phe Leu Cys Pro Glu Glu Thr Val Gly 
    290                 295                 300                 


Gly Ile Ser Pro Gly Lys Thr Pro Ser Gln Glu Val Thr Ser Glu Glu 
305                 310                 315                 320 


Glu Asn Arg Ala Thr Asp Ser Ala Thr Ile Val Ser Pro Pro Pro Ser 
                325                 330                 335     


Ser Pro Pro Ser Ser Leu Thr Thr Asp Pro Ser Gln Ser Leu Leu Ser 
            340                 345                 350         


Leu Glu Gln Glu Pro Leu Leu Ser Arg Met Gly Ser Leu Arg Ala Pro 
        355                 360                 365             


Val Asp Glu Asp Arg Leu Ser Pro Leu Val Ala Ala Asp Ser Leu Leu 
    370                 375                 380                 


Glu His Val Arg Glu Asp Phe Ser Gly Leu Leu Pro Glu Glu Phe Ile 
385                 390                 395                 400 


Ser Leu Ser Pro Pro His Glu Ala Leu Asp Tyr His Phe Gly Leu Glu 
                405                 410                 415     


Glu Gly Glu Gly Ile Arg Asp Leu Phe Asp Cys Asp Phe Gly Asp Leu 
            420                 425                 430         


Thr Pro Leu Asp Phe 
        435         


<210>  3351
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2F3__Homo_sapiens__NP_001230005

<400>  3351

Met Pro Leu Gln Gln Gln Ala Lys Arg Arg Leu Glu Leu Gly Glu Ser 
1               5                   10                  15      


Gly His Gln Tyr Leu Ser Asp Gly Leu Lys Thr Pro Lys Gly Lys Gly 
            20                  25                  30          


Arg Ala Ala Leu Arg Ser Pro Asp Ser Pro Lys Lys Lys Thr Arg Tyr 
        35                  40                  45              


Asp Thr Ser Leu Gly Leu Leu Thr Lys Lys Phe Ile Gln Leu Leu Ser 
    50                  55                  60                  


Gln Ser Pro Asp Gly Val Leu Asp Leu Asn Lys Ala Ala Glu Val Leu 
65                  70                  75                  80  


Lys Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val Leu Glu Gly 
                85                  90                  95      


Ile His Leu Ile Lys Lys Lys Ser Lys Asn Asn Val Gln Trp Met Gly 
            100                 105                 110         


Cys Ser Leu Ser Glu Asp Gly Gly Met Leu Ala Gln Cys Gln Gly Leu 
        115                 120                 125             


Ser Lys Glu Val Thr Glu Leu Ser Gln Glu Glu Lys Lys Leu Asp Glu 
    130                 135                 140                 


Leu Ile Gln Ser Cys Thr Leu Asp Leu Lys Leu Leu Thr Glu Asp Ser 
145                 150                 155                 160 


Glu Asn Gln Arg Leu Ala Tyr Val Thr Tyr Gln Asp Ile Arg Lys Ile 
                165                 170                 175     


Ser Gly Leu Lys Asp Gln Thr Val Ile Val Val Lys Ala Pro Pro Glu 
            180                 185                 190         


Thr Arg Leu Glu Val Pro Asp Ser Ile Glu Ser Leu Gln Ile His Leu 
        195                 200                 205             


Ala Ser Thr Gln Gly Pro Ile Glu Val Tyr Leu Cys Pro Glu Glu Thr 
    210                 215                 220                 


Glu Thr His Ser Pro Met Lys Thr Asn Asn Gln Asp His Asn Gly Asn 
225                 230                 235                 240 


Ile Pro Lys Pro Ala Ser Lys Asp Leu Ala Ser Thr Asn Ser Gly His 
                245                 250                 255     


Ser Asp Cys Ser Val Ser Met Gly Asn Leu Ser Pro Leu Ala Ser Pro 
            260                 265                 270         


Ala Asn Leu Leu Gln Gln Thr Glu Asp Gln Ile Pro Ser Asn Leu Glu 
        275                 280                 285             


Gly Pro Phe Val Asn Leu Leu Pro Pro Leu Leu Gln Glu Asp Tyr Leu 
    290                 295                 300                 


Leu Ser Leu Gly Glu Glu Glu Gly Ile Ser Asp Leu Phe Asp Ala Tyr 
305                 310                 315                 320 


Asp Leu Glu Lys Leu Pro Leu Val Glu Asp Phe Met Cys Ser 
                325                 330                 


<210>  3352
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2F4__Homo_sapiens__NP_001941

<400>  3352

Met Ala Glu Ala Gly Pro Gln Ala Pro Pro Pro Pro Gly Thr Pro Ser 
1               5                   10                  15      


Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser Leu 
            20                  25                  30          


Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Leu Ala Ala Asp 
        35                  40                  45              


Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val 
    50                  55                  60                  


Leu Glu Gly Ile Gly Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile Gln 
65                  70                  75                  80  


Trp Lys Gly Val Gly Pro Gly Cys Asn Thr Arg Glu Ile Ala Asp Lys 
                85                  90                  95      


Leu Ile Glu Leu Lys Ala Glu Ile Glu Glu Leu Gln Gln Arg Glu Gln 
            100                 105                 110         


Glu Leu Asp Gln His Lys Val Trp Val Gln Gln Ser Ile Arg Asn Val 
        115                 120                 125             


Thr Glu Asp Val Gln Asn Ser Cys Leu Ala Tyr Val Thr His Glu Asp 
    130                 135                 140                 


Ile Cys Arg Cys Phe Ala Gly Asp Thr Leu Leu Ala Ile Arg Ala Pro 
145                 150                 155                 160 


Ser Gly Thr Ser Leu Glu Val Pro Ile Pro Glu Gly Leu Asn Gly Gln 
                165                 170                 175     


Lys Lys Tyr Gln Ile His Leu Lys Ser Val Ser Gly Pro Ile Glu Val 
            180                 185                 190         


Leu Leu Val Asn Lys Glu Ala Trp Ser Ser Pro Pro Val Ala Val Pro 
        195                 200                 205             


Val Pro Pro Pro Glu Asp Leu Leu Gln Ser Pro Ser Ala Val Ser Thr 
    210                 215                 220                 


Pro Pro Pro Leu Pro Lys Pro Ala Leu Ala Gln Ser Gln Glu Ala Ser 
225                 230                 235                 240 


Arg Pro Asn Ser Pro Gln Leu Thr Pro Thr Ala Val Pro Gly Ser Ala 
                245                 250                 255     


Glu Val Gln Gly Met Ala Gly Pro Ala Ala Glu Ile Thr Val Ser Gly 
            260                 265                 270         


Gly Pro Gly Thr Asp Ser Lys Asp Ser Gly Glu Leu Ser Ser Leu Pro 
        275                 280                 285             


Leu Gly Pro Thr Thr Leu Asp Thr Arg Pro Leu Gln Ser Ser Ala Leu 
    290                 295                 300                 


Leu Asp Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn 
305                 310                 315                 320 


Ser Asn Ser Ser Ser Ser Ser Gly Pro Asn Pro Ser Thr Ser Phe Glu 
                325                 330                 335     


Pro Ile Lys Ala Asp Pro Thr Gly Val Leu Glu Leu Pro Lys Glu Leu 
            340                 345                 350         


Ser Glu Ile Phe Asp Pro Thr Arg Glu Cys Met Ser Ser Glu Leu Leu 
        355                 360                 365             


Glu Glu Leu Met Ser Ser Glu Val Phe Ala Pro Leu Leu Arg Leu Ser 
    370                 375                 380                 


Pro Pro Pro Gly Asp His Asp Tyr Ile Tyr Asn Leu Asp Glu Ser Glu 
385                 390                 395                 400 


Gly Val Cys Asp Leu Phe Asp Val Pro Val Leu Asn Leu 
                405                 410             


<210>  3353
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2F5__Homo_sapiens__NP_001077057

<400>  3353

Met Ala Ala Ala Glu Pro Ala Ser Ser Gly Gln Gln Ala Pro Ala Gly 
1               5                   10                  15      


Gln Gly Gln Gly Gln Arg Pro Pro Pro Gln Pro Pro Gln Ala Gln Ala 
            20                  25                  30          


Pro Gln Pro Pro Pro Pro Pro Gln Leu Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45              


Ser Arg His Glu Lys Ser Leu Gly Leu Leu Thr Thr Lys Phe Val Ser 
    50                  55                  60                  


Leu Leu Gln Glu Ala Lys Asp Gly Val Leu Asp Leu Lys Ala Ala Ala 
65                  70                  75                  80  


Asp Thr Leu Ala Val Arg Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn 
                85                  90                  95      


Val Leu Glu Gly Ile Asp Leu Ile Glu Lys Lys Ser Lys Asn Ser Ile 
            100                 105                 110         


Gln Trp Lys Gly Val Gly Ala Gly Cys Asn Thr Lys Glu Val Ile Asp 
        115                 120                 125             


Arg Leu Arg Tyr Leu Lys Ala Glu Ile Glu Asp Leu Glu Leu Lys Glu 
    130                 135                 140                 


Arg Glu Leu Asp Gln Gln Lys Leu Trp Leu Gln Gln Ser Ile Lys Asn 
145                 150                 155                 160 


Val Met Asp Asp Ser Ile Asn Asn Arg Phe Ser Tyr Val Thr His Glu 
                165                 170                 175     


Asp Ile Cys Asn Cys Phe Asn Gly Asp Thr Leu Leu Ala Ile Gln Ala 
            180                 185                 190         


Pro Ser Gly Thr Gln Leu Glu Val Pro Ile Pro Glu Met Gly Gln Asn 
        195                 200                 205             


Gly Gln Lys Lys Tyr Gln Ile Asn Leu Lys Ser His Ser Gly Pro Ile 
    210                 215                 220                 


His Val Leu Leu Ile Asn Lys Glu Ser Ser Ser Ser Lys Pro Val Val 
225                 230                 235                 240 


Phe Pro Val Pro Pro Pro Asp Asp Leu Thr Gln Pro Ser Ser Gln Ser 
                245                 250                 255     


Leu Thr Pro Val Thr Pro Gln Lys Ser Ser Met Ala Thr Gln Asn Leu 
            260                 265                 270         


Pro Glu Gln His Val Ser Glu Arg Ser Gln Ala Leu Gln Gln Thr Ser 
        275                 280                 285             


Ala Thr Asp Ile Ser Ser Gly Ser Ile Ser Gly Asp Ile Ile Asp Glu 
    290                 295                 300                 


Leu Met Ser Ser Asp Val Phe Pro Leu Leu Arg Leu Ser Pro Thr Pro 
305                 310                 315                 320 


Ala Asp Asp Tyr Asn Phe Asn Leu Asp Asp Asn Glu Gly Val Cys Asp 
                325                 330                 335     


Leu Phe Asp Val Gln Ile Leu Asn Tyr 
            340                 345 


<210>  3354
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2F6__Homo_sapiens__NP_001265204

<400>  3354

Met Asn Pro Ser Pro Ser Lys Ile Arg Ile Asn Leu Glu Asp Asn Val 
1               5                   10                  15      


Gln Tyr Val Ser Met Arg Lys Ala Leu Lys Val Lys Arg Pro Arg Phe 
            20                  25                  30          


Asp Val Ser Leu Val Tyr Leu Thr Arg Lys Phe Met Asp Leu Val Arg 
        35                  40                  45              


Ser Ala Pro Gly Gly Ile Leu Asp Leu Asn Lys Val Ala Thr Lys Leu 
    50                  55                  60                  


Gly Val Arg Lys Arg Arg Val Tyr Asp Ile Thr Asn Val Leu Asp Gly 
65                  70                  75                  80  


Ile Asp Leu Val Glu Lys Lys Ser Lys Asn His Ile Arg Trp Ile Gly 
                85                  90                  95      


Ser Asp Leu Ser Asn Phe Gly Ala Val Pro Gln Gln Lys Lys Leu Gln 
            100                 105                 110         


Glu Glu Leu Ser Asp Leu Ser Ala Met Glu Asp Ala Leu Asp Glu Leu 
        115                 120                 125             


Ile Lys Asp Cys Ala Gln Gln Leu Phe Glu Leu Thr Asp Asp Lys Glu 
    130                 135                 140                 


Asn Glu Arg Leu Ala Tyr Val Thr Tyr Gln Asp Ile His Ser Ile Gln 
145                 150                 155                 160 


Ala Phe His Glu Gln Ile Val Ile Ala Val Lys Ala Pro Ala Glu Thr 
                165                 170                 175     


Arg Leu Asp Val Pro Ala Pro Arg Glu Asp Ser Ile Thr Val His Ile 
            180                 185                 190         


Arg Ser Thr Asn Gly Pro Ile Asp Val Tyr Leu Cys Glu Val Glu Gln 
        195                 200                 205             


Gly Gln Thr Ser Asn Lys Arg Ser Glu Gly Val Gly Thr Ser Ser Ser 
    210                 215                 220                 


Glu Ser Thr His Pro Glu Gly Pro Glu Glu Glu Glu Asn Pro Gln Gln 
225                 230                 235                 240 


Ser Glu Glu Leu Leu Glu Val Ser Asn 
                245                 


<210>  3355
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2F7__Homo_sapiens__NP_976328

<400>  3355

Met Glu Val Asn Cys Leu Thr Leu Lys Asp Leu Ile Ser Pro Arg Gln 
1               5                   10                  15      


Pro Arg Leu Asp Phe Ala Val Glu Asp Gly Glu Asn Ala Gln Lys Glu 
            20                  25                  30          


Asn Ile Phe Val Asp Arg Ser Arg Met Ala Pro Lys Thr Pro Ile Lys 
        35                  40                  45              


Asn Glu Pro Ile Asp Leu Ser Lys Gln Lys Lys Phe Thr Pro Glu Arg 
    50                  55                  60                  


Asn Pro Ile Thr Pro Val Lys Phe Val Asp Arg Gln Gln Ala Glu Pro 
65                  70                  75                  80  


Trp Thr Pro Thr Ala Asn Leu Lys Met Leu Ile Ser Ala Ala Ser Pro 
                85                  90                  95      


Asp Ile Arg Asp Arg Glu Lys Lys Lys Gly Leu Phe Arg Pro Ile Glu 
            100                 105                 110         


Asn Lys Asp Asp Ala Phe Thr Asp Ser Leu Gln Leu Asp Val Val Gly 
        115                 120                 125             


Asp Ser Ala Val Asp Glu Phe Glu Lys Gln Arg Pro Ser Arg Lys Gln 
    130                 135                 140                 


Lys Ser Leu Gly Leu Leu Cys Gln Lys Phe Leu Ala Arg Tyr Pro Ser 
145                 150                 155                 160 


Tyr Pro Leu Ser Thr Glu Lys Thr Thr Ile Ser Leu Asp Glu Val Ala 
                165                 170                 175     


Val Ser Leu Gly Val Glu Arg Arg Arg Ile Tyr Asp Ile Val Asn Val 
            180                 185                 190         


Leu Glu Ser Leu His Leu Val Ser Arg Val Ala Lys Asn Gln Tyr Gly 
        195                 200                 205             


Trp His Gly Arg His Ser Leu Pro Lys Thr Leu Arg Asn Leu Gln Arg 
    210                 215                 220                 


Leu Gly Glu Glu Gln Lys Tyr Glu Glu Gln Met Ala Tyr Leu Gln Gln 
225                 230                 235                 240 


Lys Glu Leu Asp Leu Ile Asp Tyr Lys Phe Gly Glu Arg Lys Lys Asp 
                245                 250                 255     


Gly Asp Pro Asp Ser Gln Glu Gln Gln Leu Leu Asp Phe Ser Glu Pro 
            260                 265                 270         


Asp Cys Pro Ser Ser Ser Ala Asn Ser Arg Lys Asp Lys Ser Leu Arg 
        275                 280                 285             


Ile Met Ser Gln Lys Phe Val Met Leu Phe Leu Val Ser Lys Thr Lys 
    290                 295                 300                 


Ile Val Thr Leu Asp Val Ala Ala Lys Ile Leu Ile Glu Glu Ser Gln 
305                 310                 315                 320 


Asp Ala Pro Asp His Ser Lys Phe Lys Thr Lys Val Arg Arg Leu Tyr 
                325                 330                 335     


Asp Ile Ala Asn Val Leu Thr Ser Leu Ala Leu Ile Lys Lys Val His 
            340                 345                 350         


Val Thr Glu Glu Arg Gly Arg Lys Pro Ala Phe Lys Trp Ile Gly Pro 
        355                 360                 365             


Val Asp Phe Ser Ser Ser Asp Glu Glu Leu Val Asp Val Ser Ala Ser 
    370                 375                 380                 


Val Leu Pro Glu Leu Lys Arg Glu Thr Tyr Gly Gln Ile Gln Val Cys 
385                 390                 395                 400 


Ala Lys Gln Lys Leu Ala Arg His Gly Ser Phe Asn Thr Val Gln Ala 
                405                 410                 415     


Ser Glu Arg Ile Gln Arg Lys Val Asn Ser Glu Pro Ser Ser Pro Tyr 
            420                 425                 430         


Arg Glu Glu Gln Gly Ser Gly Gly Tyr Ser Leu Glu Ile Gly Ser Leu 
        435                 440                 445             


Ala Ala Val Tyr Arg Gln Lys Ile Glu Asp Asn Ser Gln Gly Lys Ala 
    450                 455                 460                 


Phe Ala Ser Lys Arg Val Val Pro Pro Ser Ser Ser Leu Asp Pro Val 
465                 470                 475                 480 


Ala Pro Phe Pro Val Leu Ser Val Asp Pro Glu Tyr Cys Val Asn Pro 
                485                 490                 495     


Leu Ala His Pro Val Phe Ser Val Ala Gln Thr Asp Leu Gln Ala Phe 
            500                 505                 510         


Ser Met Gln Asn Gly Leu Asn Gly Gln Val Asp Val Ser Leu Ala Ser 
        515                 520                 525             


Ala Ala Ser Ala Val Glu Ser Leu Lys Pro Ala Leu Leu Ala Gly Gln 
    530                 535                 540                 


Pro Leu Val Tyr Val Pro Ser Ala Ser Leu Phe Met Leu Tyr Gly Ser 
545                 550                 555                 560 


Leu Gln Glu Gly Pro Ala Ser Gly Ser Gly Ser Glu Arg Asp Asp Arg 
                565                 570                 575     


Ser Ser Glu Ala Pro Ala Thr Val Glu Leu Ser Ser Ala Pro Ser Ala 
            580                 585                 590         


Gln Lys Arg Leu Cys Glu Glu Arg Lys Pro Gln Glu Glu Asp Glu Pro 
        595                 600                 605             


Ala Thr Lys Arg Gln Ser Arg Glu Tyr Glu Asp Gly Pro Leu Ser Leu 
    610                 615                 620                 


Val Met Pro Lys Lys Pro Ser Asp Ser Thr Asp Leu Ala Ser Pro Lys 
625                 630                 635                 640 


Thr Met Gly Asn Arg Ala Ser Ile Pro Leu Lys Asp Ile His Val Asn 
                645                 650                 655     


Gly Gln Leu Pro Ala Ala Glu Glu Ile Ser Gly Lys Ala Thr Ala Asn 
            660                 665                 670         


Ser Leu Val Ser Ser Glu Trp Gly Asn Pro Ser Arg Asn Thr Asp Val 
        675                 680                 685             


Glu Lys Pro Ser Lys Glu Asn Glu Ser Thr Lys Glu Pro Ser Leu Leu 
    690                 695                 700                 


Gln Tyr Leu Cys Val Gln Ser Pro Ala Gly Leu Asn Gly Phe Asn Val 
705                 710                 715                 720 


Leu Leu Ser Gly Ser Gln Thr Pro Pro Thr Val Gly Pro Ser Ser Gly 
                725                 730                 735     


Gln Leu Pro Ser Phe Ser Val Pro Cys Met Val Leu Pro Ser Pro Pro 
            740                 745                 750         


Leu Gly Pro Phe Pro Val Leu Tyr Ser Pro Ala Met Pro Gly Pro Val 
        755                 760                 765             


Ser Ser Thr Leu Gly Ala Leu Pro Asn Thr Gly Pro Val Asn Phe Ser 
    770                 775                 780                 


Leu Pro Gly Leu Gly Ser Ile Ala Gln Leu Leu Val Gly Pro Thr Ala 
785                 790                 795                 800 


Val Val Asn Pro Lys Ser Ser Thr Leu Pro Ser Ala Asp Pro Gln Leu 
                805                 810                 815     


Gln Ser Gln Pro Ser Leu Asn Leu Ser Pro Val Met Ser Arg Ser His 
            820                 825                 830         


Ser Val Val Gln Gln Pro Glu Ser Pro Val Tyr Val Gly His Pro Val 
        835                 840                 845             


Ser Val Val Lys Leu His Gln Ser Pro Val Pro Val Thr Pro Lys Ser 
    850                 855                 860                 


Ile Gln Arg Thr His Arg Glu Thr Phe Phe Lys Thr Pro Gly Ser Leu 
865                 870                 875                 880 


Gly Asp Pro Val Leu Lys Arg Arg Glu Arg Asn Gln Ser Arg Asn Thr 
                885                 890                 895     


Ser Ser Ala Gln Arg Arg Leu Glu Ile Pro Ser Gly Gly Ala Asp 
            900                 905                 910     


<210>  3356
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2F8__Homo_sapiens__NP_078956

<400>  3356

Met Glu Asn Glu Lys Glu Asn Leu Phe Cys Glu Pro His Lys Arg Gly 
1               5                   10                  15      


Leu Met Lys Thr Pro Leu Lys Glu Ser Thr Thr Ala Asn Ile Val Leu 
            20                  25                  30          


Ala Glu Ile Gln Pro Asp Phe Gly Pro Leu Thr Thr Pro Thr Lys Pro 
        35                  40                  45              


Lys Glu Gly Ser Gln Gly Glu Pro Trp Thr Pro Thr Ala Asn Leu Lys 
    50                  55                  60                  


Met Leu Ile Ser Ala Val Ser Pro Glu Ile Arg Asn Arg Asp Gln Lys 
65                  70                  75                  80  


Arg Gly Leu Phe Asp Asn Arg Ser Gly Leu Pro Glu Ala Lys Asp Cys 
                85                  90                  95      


Ile His Glu His Leu Ser Gly Asp Glu Phe Glu Lys Ser Gln Pro Ser 
            100                 105                 110         


Arg Lys Glu Lys Ser Leu Gly Leu Leu Cys His Lys Phe Leu Ala Arg 
        115                 120                 125             


Tyr Pro Asn Tyr Pro Asn Pro Ala Val Asn Asn Asp Ile Cys Leu Asp 
    130                 135                 140                 


Glu Val Ala Glu Glu Leu Asn Val Glu Arg Arg Arg Ile Tyr Asp Ile 
145                 150                 155                 160 


Val Asn Val Leu Glu Ser Leu His Met Val Ser Arg Leu Ala Lys Asn 
                165                 170                 175     


Arg Tyr Thr Trp His Gly Arg His Asn Leu Asn Lys Thr Leu Gly Thr 
            180                 185                 190         


Leu Lys Ser Ile Gly Glu Glu Asn Lys Tyr Ala Glu Gln Ile Met Met 
        195                 200                 205             


Ile Lys Lys Lys Glu Tyr Glu Gln Glu Phe Asp Phe Ile Lys Ser Tyr 
    210                 215                 220                 


Ser Ile Glu Asp His Ile Ile Lys Ser Asn Thr Gly Pro Asn Gly His 
225                 230                 235                 240 


Pro Asp Met Cys Phe Val Glu Leu Pro Gly Val Glu Phe Arg Ala Ala 
                245                 250                 255     


Ser Val Asn Ser Arg Lys Asp Lys Ser Leu Arg Val Met Ser Gln Lys 
            260                 265                 270         


Phe Val Met Leu Phe Leu Val Ser Thr Pro Gln Ile Val Ser Leu Glu 
        275                 280                 285             


Val Ala Ala Lys Ile Leu Ile Gly Glu Asp His Val Glu Asp Leu Asp 
    290                 295                 300                 


Lys Ser Lys Phe Lys Thr Lys Ile Arg Arg Leu Tyr Asp Ile Ala Asn 
305                 310                 315                 320 


Val Leu Ser Ser Leu Asp Leu Ile Lys Lys Val His Val Thr Glu Glu 
                325                 330                 335     


Arg Gly Arg Lys Pro Ala Phe Lys Trp Thr Gly Pro Glu Ile Ser Pro 
            340                 345                 350         


Asn Thr Ser Gly Ser Ser Pro Val Ile His Phe Thr Pro Ser Asp Leu 
        355                 360                 365             


Glu Val Arg Arg Ser Ser Lys Glu Asn Cys Ala Lys Asn Leu Phe Ser 
    370                 375                 380                 


Thr Arg Gly Lys Pro Asn Phe Thr Arg His Pro Ser Leu Ile Lys Leu 
385                 390                 395                 400 


Val Lys Ser Ile Glu Ser Asp Arg Arg Lys Ile Asn Ser Ala Pro Ser 
                405                 410                 415     


Ser Pro Ile Lys Thr Asn Lys Ala Glu Ser Ser Gln Asn Ser Ala Pro 
            420                 425                 430         


Phe Pro Ser Lys Met Ala Gln Leu Ala Ala Ile Cys Lys Met Gln Leu 
        435                 440                 445             


Glu Glu Gln Ser Ser Glu Ser Arg Gln Lys Val Lys Val Gln Leu Ala 
    450                 455                 460                 


Arg Ser Gly Pro Cys Lys Pro Val Ala Pro Leu Asp Pro Pro Val Asn 
465                 470                 475                 480 


Ala Glu Met Glu Leu Thr Ala Pro Ser Leu Ile Gln Pro Leu Gly Met 
                485                 490                 495     


Val Pro Leu Ile Pro Ser Pro Leu Ser Ser Ala Val Pro Leu Ile Leu 
            500                 505                 510         


Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Ile Tyr Leu Gln Pro Thr 
        515                 520                 525             


Gln Ala His Gln Ser Val Thr Pro Pro Gln Gly Leu Ser Pro Thr Val 
    530                 535                 540                 


Cys Thr Thr His Ser Ser Lys Ala Thr Gly Ser Lys Asp Ser Thr Asp 
545                 550                 555                 560 


Ala Thr Thr Glu Lys Ala Ala Asn Asp Thr Ser Lys Ala Ser Ala Ser 
                565                 570                 575     


Thr Arg Pro Gly Ser Leu Leu Pro Ala Pro Glu Arg Gln Gly Ala Lys 
            580                 585                 590         


Ser Arg Thr Arg Glu Pro Ala Gly Glu Arg Gly Ser Lys Arg Ala Ser 
        595                 600                 605             


Met Leu Glu Asp Ser Gly Ser Lys Lys Lys Phe Lys Glu Asp Leu Lys 
    610                 615                 620                 


Gly Leu Glu Asn Val Ser Ala Thr Leu Phe Pro Ser Gly Tyr Leu Ile 
625                 630                 635                 640 


Pro Leu Thr Gln Cys Ser Ser Leu Gly Ala Glu Ser Ile Leu Ser Gly 
                645                 650                 655     


Lys Glu Asn Ser Ser Ala Leu Ser Pro Asn His Arg Ile Tyr Ser Ser 
            660                 665                 670         


Pro Ile Ala Gly Val Ile Pro Val Thr Ser Ser Glu Leu Thr Ala Val 
        675                 680                 685             


Asn Phe Pro Ser Phe His Val Thr Pro Leu Lys Leu Met Val Ser Pro 
    690                 695                 700                 


Thr Ser Val Ala Ala Val Pro Val Gly Asn Ser Pro Ala Leu Ala Ser 
705                 710                 715                 720 


Ser His Pro Val Pro Ile Gln Asn Pro Ser Ser Ala Ile Val Asn Phe 
                725                 730                 735     


Thr Leu Gln His Leu Gly Leu Ile Ser Pro Asn Val Gln Leu Ser Ala 
            740                 745                 750         


Ser Pro Gly Ser Gly Ile Val Pro Val Ser Pro Arg Ile Glu Ser Val 
        755                 760                 765             


Asn Val Ala Pro Glu Asn Ala Gly Thr Gln Gln Gly Arg Ala Thr Asn 
    770                 775                 780                 


Tyr Asp Ser Pro Val Pro Gly Gln Ser Gln Pro Asn Gly Gln Ser Val 
785                 790                 795                 800 


Ala Val Thr Gly Ala Gln Gln Pro Val Pro Val Thr Pro Lys Gly Ser 
                805                 810                 815     


Gln Leu Val Ala Glu Ser Phe Phe Arg Thr Pro Gly Gly Pro Thr Lys 
            820                 825                 830         


Pro Thr Ser Ser Ser Cys Met Asp Phe Glu Gly Ala Asn Lys Thr Ser 
        835                 840                 845             


Leu Gly Thr Leu Phe Val Pro Gln Arg Lys Leu Glu Val Ser Thr Glu 
    850                 855                 860                 


Asp Val His 
865         


<210>  3357
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E4F1__Homo_sapiens__NP_004415

<400>  3357

Met Glu Gly Ala Met Ala Val Arg Val Thr Ala Ala His Thr Ala Glu 
1               5                   10                  15      


Ala Gln Ala Glu Ala Gly Arg Glu Ala Gly Glu Gly Ala Val Ala Ala 
            20                  25                  30          


Val Ala Ala Ala Leu Ala Pro Ser Gly Phe Leu Gly Leu Pro Ala Pro 
        35                  40                  45              


Phe Ser Glu Glu Asp Glu Asp Asp Val His Arg Cys Gly Arg Cys Gln 
    50                  55                  60                  


Ala Glu Phe Thr Ala Leu Glu Asp Phe Val Gln His Lys Ile Gln Lys 
65                  70                  75                  80  


Ala Cys Gln Arg Ala Pro Pro Glu Ala Leu Pro Ala Thr Pro Ala Thr 
                85                  90                  95      


Thr Ala Leu Leu Gly Gln Glu Val Val Pro Ala Ala Pro Gly Pro Glu 
            100                 105                 110         


Glu Pro Ile Thr Val Ala His Ile Val Val Glu Ala Ala Ser Leu Ala 
        115                 120                 125             


Ala Asp Ile Ser His Ala Ser Asp Leu Val Gly Gly Gly His Ile Lys 
    130                 135                 140                 


Glu Val Ile Val Ala Ala Glu Ala Glu Leu Gly Asp Gly Glu Met Ala 
145                 150                 155                 160 


Glu Ala Pro Gly Ser Pro His Gln Gln Gly Leu Gly Leu Ala Gly Glu 
                165                 170                 175     


Gly Glu Gln Ala Gln Val Lys Leu Leu Val Asn Lys Asp Gly Arg Tyr 
            180                 185                 190         


Val Cys Ala Leu Cys His Lys Thr Phe Lys Thr Gly Ser Ile Leu Lys 
        195                 200                 205             


Ala His Met Val Thr His Ser Ser Arg Lys Asp His Glu Cys Lys Leu 
    210                 215                 220                 


Cys Gly Ala Ser Phe Arg Thr Lys Gly Ser Leu Ile Arg His His Arg 
225                 230                 235                 240 


Arg His Thr Asp Glu Arg Pro Tyr Lys Cys Ser Lys Cys Gly Lys Ser 
                245                 250                 255     


Phe Arg Glu Ser Gly Ala Leu Thr Arg His Leu Lys Ser Leu Thr Pro 
            260                 265                 270         


Cys Thr Glu Lys Ile Arg Phe Ser Val Ser Lys Asp Val Val Val Ser 
        275                 280                 285             


Lys Glu Asp Ala Arg Ala Gly Ser Gly Ala Gly Ala Ala Gly Leu Gly 
    290                 295                 300                 


Thr Ala Thr Ser Ser Val Thr Gly Glu Pro Ile Glu Thr Ser Pro Val 
305                 310                 315                 320 


Ile His Leu Val Thr Asp Ala Lys Gly Thr Val Ile His Glu Val His 
                325                 330                 335     


Val Gln Met Gln Glu Leu Ser Leu Gly Met Lys Ala Leu Ala Pro Glu 
            340                 345                 350         


Pro Pro Val Ser Gln Glu Leu Pro Cys Ser Ser Glu Gly Ser Arg Glu 
        355                 360                 365             


Asn Leu Leu His Gln Ala Met Gln Asn Ser Gly Ile Val Leu Glu Arg 
    370                 375                 380                 


Ala Ala Gly Glu Glu Gly Ala Leu Glu Pro Ala Pro Ala Ala Gly Ser 
385                 390                 395                 400 


Ser Pro Gln Pro Leu Ala Val Ala Ala Pro Gln Leu Pro Val Leu Glu 
                405                 410                 415     


Val Gln Pro Leu Glu Thr Gln Val Ala Ser Glu Ala Ser Ala Val Pro 
            420                 425                 430         


Arg Thr His Pro Cys Pro Gln Cys Ser Glu Thr Phe Pro Thr Ala Ala 
        435                 440                 445             


Thr Leu Glu Ala His Lys Arg Gly His Thr Gly Pro Arg Pro Phe Ala 
    450                 455                 460                 


Cys Ala Gln Cys Gly Lys Ala Phe Pro Lys Ala Tyr Leu Leu Lys Lys 
465                 470                 475                 480 


His Gln Glu Val His Val Arg Glu Arg Arg Phe Arg Cys Gly Asp Cys 
                485                 490                 495     


Gly Lys Leu Tyr Lys Thr Ile Ala His Val Arg Gly His Arg Arg Val 
            500                 505                 510         


His Ser Asp Glu Arg Pro Tyr Pro Cys Pro Lys Cys Gly Lys Arg Tyr 
        515                 520                 525             


Lys Thr Lys Asn Ala Gln Gln Val His Phe Arg Thr His Leu Glu Glu 
    530                 535                 540                 


Lys Pro His Val Cys Gln Phe Cys Ser Arg Gly Phe Arg Glu Lys Gly 
545                 550                 555                 560 


Ser Leu Val Arg His Val Arg His His Thr Gly Glu Lys Pro Phe Lys 
                565                 570                 575     


Cys Tyr Lys Cys Gly Arg Gly Phe Ala Glu His Gly Thr Leu Asn Arg 
            580                 585                 590         


His Leu Arg Thr Lys Gly Gly Cys Leu Leu Glu Val Glu Glu Leu Leu 
        595                 600                 605             


Val Ser Glu Asp Ser Pro Ala Ala Ala Thr Thr Val Leu Thr Glu Asp 
    610                 615                 620                 


Pro His Thr Val Leu Val Glu Phe Ser Ser Val Val Ala Asp Thr Gln 
625                 630                 635                 640 


Glu Tyr Ile Ile Glu Ala Thr Ala Asp Asp Ala Glu Thr Ser Glu Ala 
                645                 650                 655     


Thr Glu Ile Ile Glu Gly Thr Gln Thr Glu Val Asp Ser His Ile Met 
            660                 665                 670         


Lys Val Val Gln Gln Ile Val His Gln Ala Ser Ala Gly His Gln Ile 
        675                 680                 685             


Ile Val Gln Asn Val Thr Met Asp Glu Glu Thr Ala Leu Gly Pro Glu 
    690                 695                 700                 


Ala Ala Ala Ala Asp Thr Ile Thr Ile Ala Thr Pro Glu Ser Leu Thr 
705                 710                 715                 720 


Glu Gln Val Ala Met Thr Leu Ala Ser Ala Ile Ser Glu Gly Thr Val 
                725                 730                 735     


Leu Ala Ala Arg Ala Gly Thr Ser Gly Thr Glu Gln Ala Thr Val Thr 
            740                 745                 750         


Met Val Ser Ser Glu Asp Ile Glu Ile Leu Glu His Ala Gly Glu Leu 
        755                 760                 765             


Val Ile Ala Ser Pro Glu Gly Gln Leu Glu Val Gln Thr Val Ile Val 
    770                 775                 780                 


<210>  3358
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EAF1__Homo_sapiens__NP_149074

<400>  3358

Met Asn Gly Thr Ala Asn Pro Leu Leu Asp Arg Glu Glu His Cys Leu 
1               5                   10                  15      


Arg Leu Gly Glu Ser Phe Glu Lys Arg Pro Arg Ala Ser Phe His Thr 
            20                  25                  30          


Ile Arg Tyr Asp Phe Lys Pro Ala Ser Ile Asp Thr Ser Cys Glu Gly 
        35                  40                  45              


Glu Leu Gln Val Gly Lys Gly Asp Glu Val Thr Ile Thr Leu Pro His 
    50                  55                  60                  


Ile Pro Gly Ser Thr Pro Pro Met Thr Val Phe Lys Gly Asn Lys Arg 
65                  70                  75                  80  


Pro Tyr Gln Lys Asp Cys Val Leu Ile Ile Asn His Asp Thr Gly Glu 
                85                  90                  95      


Tyr Val Leu Glu Lys Leu Ser Ser Ser Ile Gln Val Lys Lys Thr Arg 
            100                 105                 110         


Ala Glu Gly Ser Ser Lys Ile Gln Ala Arg Met Glu Gln Gln Pro Thr 
        115                 120                 125             


Arg Pro Pro Gln Thr Ser Gln Pro Pro Pro Pro Pro Pro Pro Met Pro 
    130                 135                 140                 


Phe Arg Ala Pro Thr Lys Pro Pro Val Gly Pro Lys Thr Ser Pro Leu 
145                 150                 155                 160 


Lys Asp Asn Pro Ser Pro Glu Pro Gln Leu Asp Asp Ile Lys Arg Glu 
                165                 170                 175     


Leu Arg Ala Glu Val Asp Ile Ile Glu Gln Met Ser Ser Ser Ser Gly 
            180                 185                 190         


Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser Gly Ser Asp Asp Asp Ser 
        195                 200                 205             


Ser Ser Ser Gly Gly Glu Asp Asn Gly Pro Ala Ser Pro Pro Gln Pro 
    210                 215                 220                 


Ser His Gln Gln Pro Tyr Asn Ser Arg Pro Ala Val Ala Asn Gly Thr 
225                 230                 235                 240 


Ser Arg Pro Gln Gly Ser Asn Gln Leu Met Asn Thr Leu Arg Asn Asp 
                245                 250                 255     


Leu Gln Leu Ser Glu Ser Gly Ser Asp Ser Asp Asp 
            260                 265             


<210>  3359
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EAF2__Homo_sapiens__NP_060926

<400>  3359

Met Asn Ser Ala Ala Gly Phe Ser His Leu Asp Arg Arg Glu Arg Val 
1               5                   10                  15      


Leu Lys Leu Gly Glu Ser Phe Glu Lys Gln Pro Arg Cys Ala Phe His 
            20                  25                  30          


Thr Val Arg Tyr Asp Phe Lys Pro Ala Ser Ile Asp Thr Ser Ser Glu 
        35                  40                  45              


Gly Tyr Leu Glu Val Gly Glu Gly Glu Gln Val Thr Ile Thr Leu Pro 
    50                  55                  60                  


Asn Ile Glu Gly Ser Thr Pro Pro Val Thr Val Phe Lys Gly Ser Lys 
65                  70                  75                  80  


Lys Pro Tyr Leu Lys Glu Cys Ile Leu Ile Ile Asn His Asp Thr Gly 
                85                  90                  95      


Glu Cys Arg Leu Glu Lys Leu Ser Ser Asn Ile Thr Val Lys Lys Thr 
            100                 105                 110         


Arg Val Glu Gly Ser Ser Lys Ile Gln Tyr Arg Lys Glu Gln Gln Gln 
        115                 120                 125             


Gln Gln Met Trp Asn Ser Ala Arg Thr Pro Asn Leu Val Lys His Ser 
    130                 135                 140                 


Pro Ser Glu Asp Lys Met Ser Pro Ala Ser Pro Ile Asp Asp Ile Glu 
145                 150                 155                 160 


Arg Glu Leu Lys Ala Glu Ala Ser Leu Met Asp Gln Met Ser Ser Cys 
                165                 170                 175     


Asp Ser Ser Ser Asp Ser Lys Ser Ser Ser Ser Ser Ser Ser Glu Asp 
            180                 185                 190         


Ser Ser Ser Asp Ser Glu Asp Glu Asp Cys Lys Ser Ser Thr Ser Asp 
        195                 200                 205             


Thr Gly Asn Cys Val Ser Gly His Pro Thr Met Thr Gln Tyr Arg Ile 
    210                 215                 220                 


Pro Asp Ile Asp Ala Ser His Asn Arg Phe Arg Asp Asn Ser Gly Leu 
225                 230                 235                 240 


Leu Met Asn Thr Leu Arg Asn Asp Leu Gln Leu Ser Glu Ser Gly Ser 
                245                 250                 255     


Asp Ser Asp Asp 
            260 


<210>  3360
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EARS2__Homo_sapiens__NP_001077083

<400>  3360

Met Ala Ala Leu Leu Arg Arg Leu Leu Gln Arg Glu Arg Pro Ser Ala 
1               5                   10                  15      


Ala Ser Gly Arg Pro Val Gly Arg Arg Glu Ala Asn Leu Gly Thr Asp 
            20                  25                  30          


Ala Gly Val Ala Val Arg Val Arg Phe Ala Pro Ser Pro Thr Gly Phe 
        35                  40                  45              


Leu His Leu Gly Gly Leu Arg Thr Ala Leu Tyr Asn Tyr Ile Phe Ala 
    50                  55                  60                  


Lys Lys Tyr Gln Gly Ser Phe Ile Leu Arg Leu Glu Asp Thr Asp Gln 
65                  70                  75                  80  


Thr Arg Val Val Pro Gly Ala Ala Glu Asn Ile Glu Asp Met Leu Glu 
                85                  90                  95      


Trp Ala Gly Ile Pro Pro Asp Glu Ser Pro Arg Arg Gly Gly Pro Ala 
            100                 105                 110         


Gly Pro Tyr Gln Gln Ser Gln Arg Leu Glu Leu Tyr Ala Gln Ala Thr 
        115                 120                 125             


Glu Ala Leu Leu Lys Thr Gly Ala Ala Tyr Pro Cys Phe Cys Ser Pro 
    130                 135                 140                 


Gln Arg Leu Glu Leu Leu Lys Lys Glu Ala Leu Arg Asn His Gln Thr 
145                 150                 155                 160 


Pro Arg Tyr Asp Asn Arg Cys Arg Asn Met Ser Gln Glu Gln Val Ala 
                165                 170                 175     


Gln Lys Leu Ala Lys Asp Pro Lys Pro Ala Ile Arg Phe Arg Leu Glu 
            180                 185                 190         


Gln Val Val Pro Ala Phe Gln Asp Leu Val Tyr Gly Trp Asn Arg His 
        195                 200                 205             


Glu Val Ala Ser Val Glu Gly Asp Pro Val Ile Met Lys Ser Asp Gly 
    210                 215                 220                 


Phe Pro Thr Tyr His Leu Ala Cys Val Val Asp Asp His His Met Gly 
225                 230                 235                 240 


Ile Ser His Val Leu Arg Gly Ser Glu Trp Leu Val Ser Thr Ala Lys 
                245                 250                 255     


His Leu Leu Leu Tyr Gln Ala Leu Gly Trp Gln Pro Pro His Phe Ala 
            260                 265                 270         


His Leu Pro Leu Leu Leu Asn Arg Asp Gly Ser Lys Leu Ser Lys Arg 
        275                 280                 285             


Gln Gly Asp Val Phe Leu Glu His Phe Ala Ala Asp Gly Phe Leu Pro 
    290                 295                 300                 


Asp Ser Leu Leu Asp Ile Ile Thr Asn Cys Gly Ser Gly Phe Ala Glu 
305                 310                 315                 320 


Asn Gln Met Gly Arg Thr Leu Pro Glu Leu Ile Thr Gln Phe Asn Leu 
                325                 330                 335     


Thr Gln Val Thr Cys His Ser Ala Leu Leu Asp Leu Glu Lys Leu Pro 
            340                 345                 350         


Glu Phe Asn Arg Leu His Leu Gln Arg Leu Val Ser Asn Glu Ser Gln 
        355                 360                 365             


Arg Arg Gln Leu Val Gly Lys Leu Gln Val Leu Val Glu Glu Ala Phe 
    370                 375                 380                 


Gly Cys Gln Leu Gln Asn Arg Asp Val Leu Asn Pro Val Tyr Val Glu 
385                 390                 395                 400 


Arg Ile Leu Leu Leu Arg Gln Gly His Ile Cys Arg Leu Gln Asp Leu 
                405                 410                 415     


Val Ser Pro Val Tyr Ser Tyr Leu Trp Thr Arg Pro Ala Val Gly Arg 
            420                 425                 430         


Ala Gln Leu Asp Ala Ile Ser Glu Lys Val Asp Val Ile Ala Lys Arg 
        435                 440                 445             


Val Leu Gly Leu Leu Glu Arg Ser Ser Met Ser Leu Thr Gln Asp Met 
    450                 455                 460                 


Leu Asn Gly Glu Leu Lys Lys Leu Ser Glu Gly Leu Glu Gly Thr Lys 
465                 470                 475                 480 


Tyr Ser Asn Val Met Lys Leu Leu Arg Met Ala Leu Ser Gly Gln Gln 
                485                 490                 495     


Gln Gly Pro Pro Val Ala Glu Met Met Leu Ala Leu Gly Pro Lys Glu 
            500                 505                 510         


Val Arg Glu Arg Ile Gln Lys Val Val Ser Ser 
        515                 520             


<210>  3361
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBAG9__Homo_sapiens__NP_001265867

<400>  3361

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Gln Gln 
                165                 170                 175     


Lys Leu Ala Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys 
            180                 185                 190         


Met Glu Lys Glu Ala Gln Arg Leu Met Lys Lys Glu Gln Asn Lys Ile 
        195                 200                 205             


Gly Val Lys Leu Ser 
    210             


<210>  3362
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBF1__Homo_sapiens__NP_076870

<400>  3362

Met Phe Gly Ile Gln Glu Ser Ile Gln Arg Ser Gly Ser Ser Met Lys 
1               5                   10                  15      


Glu Glu Pro Leu Gly Ser Gly Met Asn Ala Val Arg Thr Trp Met Gln 
            20                  25                  30          


Gly Ala Gly Val Leu Asp Ala Asn Thr Ala Ala Gln Ser Gly Val Gly 
        35                  40                  45              


Leu Ala Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys 
    50                  55                  60                  


Ser Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln 
65                  70                  75                  80  


Pro Val Glu Ile Glu Arg Thr Ala Phe Val Gly Phe Val Glu Lys Glu 
                85                  90                  95      


Lys Glu Ala Asn Ser Glu Lys Thr Asn Asn Gly Ile His Tyr Arg Leu 
            100                 105                 110         


Gln Leu Leu Tyr Ser Asn Gly Ile Arg Thr Glu Gln Asp Phe Tyr Val 
        115                 120                 125             


Arg Leu Ile Asp Ser Met Thr Lys Gln Ala Ile Val Tyr Glu Gly Gln 
    130                 135                 140                 


Asp Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Ile Met 
145                 150                 155                 160 


Cys Ser Arg Cys Cys Asp Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr 
                165                 170                 175     


Pro Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu 
            180                 185                 190         


Lys Cys Asn Gln Asn Cys Leu Lys Asn Ala Gly Asn Pro Arg Asp Met 
        195                 200                 205             


Arg Arg Phe Gln Val Val Val Ser Thr Thr Val Asn Val Asp Gly His 
    210                 215                 220                 


Val Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His 
225                 230                 235                 240 


Gly Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Gly Thr Pro Ser Tyr 
                245                 250                 255     


Leu Glu His Ala Thr Pro Cys Ile Lys Ala Ile Ser Pro Ser Glu Gly 
            260                 265                 270         


Trp Thr Thr Gly Gly Ala Thr Val Ile Ile Ile Gly Asp Asn Phe Phe 
        275                 280                 285             


Asp Gly Leu Gln Val Ile Phe Gly Thr Met Leu Val Trp Ser Glu Leu 
    290                 295                 300                 


Ile Thr Pro His Ala Ile Arg Val Gln Thr Pro Pro Arg His Ile Pro 
305                 310                 315                 320 


Gly Val Val Glu Val Thr Leu Ser Tyr Lys Ser Lys Gln Phe Cys Lys 
                325                 330                 335     


Gly Thr Pro Gly Arg Phe Ile Tyr Thr Ala Leu Asn Glu Pro Thr Ile 
            340                 345                 350         


Asp Tyr Gly Phe Gln Arg Leu Gln Lys Val Ile Pro Arg His Pro Gly 
        355                 360                 365             


Asp Pro Glu Arg Leu Pro Lys Glu Val Ile Leu Lys Arg Ala Ala Asp 
    370                 375                 380                 


Leu Val Glu Ala Leu Tyr Gly Met Pro His Asn Asn Gln Glu Ile Ile 
385                 390                 395                 400 


Leu Lys Arg Ala Ala Asp Ile Ala Glu Ala Leu Tyr Ser Val Pro Arg 
                405                 410                 415     


Asn His Asn Gln Leu Pro Ala Leu Ala Asn Thr Ser Val His Ala Gly 
            420                 425                 430         


Met Met Gly Val Asn Ser Phe Ser Gly Gln Leu Ala Val Asn Val Ser 
        435                 440                 445             


Glu Ala Ser Gln Ala Thr Asn Gln Gly Phe Thr Arg Asn Ser Ser Ser 
    450                 455                 460                 


Val Ser Pro His Gly Tyr Val Pro Ser Thr Thr Pro Gln Gln Thr Asn 
465                 470                 475                 480 


Tyr Asn Ser Val Thr Thr Ser Met Asn Gly Tyr Gly Ser Ala Ala Met 
                485                 490                 495     


Ser Asn Leu Gly Gly Ser Pro Thr Phe Leu Asn Gly Ser Ala Ala Asn 
            500                 505                 510         


Ser Pro Tyr Ala Ile Val Pro Ser Ser Pro Thr Met Ala Ser Ser Thr 
        515                 520                 525             


Ser Leu Pro Ser Asn Cys Ser Ser Ser Ser Gly Ile Phe Ser Phe Ser 
    530                 535                 540                 


Pro Ala Asn Met Val Ser Ala Val Lys Gln Lys Ser Ala Phe Ala Pro 
545                 550                 555                 560 


Val Val Arg Pro Gln Thr Ser Pro Pro Pro Thr Cys Thr Ser Thr Asn 
                565                 570                 575     


Gly Asn Ser Leu Gln Ala Ile Ser Gly Met Ile Val Pro Pro Met 
            580                 585                 590     


<210>  3363
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBF2__Homo_sapiens__NP_073150

<400>  3363

Met Phe Gly Ile Gln Asp Thr Leu Gly Arg Gly Pro Thr Leu Lys Glu 
1               5                   10                  15      


Lys Ser Leu Gly Ala Glu Met Asp Ser Val Arg Ser Trp Val Arg Asn 
            20                  25                  30          


Val Gly Val Val Asp Ala Asn Val Ala Ala Gln Ser Gly Val Ala Leu 
        35                  40                  45              


Ser Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys Ser 
    50                  55                  60                  


Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln Pro 
65                  70                  75                  80  


Val Glu Ile Glu Arg Thr Ala Phe Val Asp Phe Val Glu Asn Asp Lys 
                85                  90                  95      


Glu Gln Gly Asn Glu Lys Thr Asn Asn Gly Thr His Tyr Lys Leu Gln 
            100                 105                 110         


Leu Leu Tyr Ser Asn Gly Val Arg Thr Glu Gln Asp Leu Tyr Val Arg 
        115                 120                 125             


Leu Ile Asp Ser Val Thr Lys Gln Pro Ile Ala Tyr Glu Gly Gln Asn 
    130                 135                 140                 


Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Val Met Cys 
145                 150                 155                 160 


Ser Arg Cys Cys Glu Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro 
                165                 170                 175     


Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys 
            180                 185                 190         


Cys Asn Gln Asn Cys Leu Lys Thr Ala Gly Asn Pro Arg Asp Met Arg 
        195                 200                 205             


Arg Phe Gln Val Val Leu Ser Thr Thr Val Asn Val Asp Gly His Val 
    210                 215                 220                 


Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His Gly 
225                 230                 235                 240 


Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Ala Thr Pro Cys Ile Lys 
                245                 250                 255     


Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Met Val Ile 
            260                 265                 270         


Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Val Phe Gly Thr 
        275                 280                 285             


Met Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val Gln 
    290                 295                 300                 


Thr Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser Tyr 
305                 310                 315                 320 


Lys Ser Lys Gln Phe Cys Lys Gly Ala Pro Gly Arg Phe Ile Tyr Thr 
                325                 330                 335     


Ala Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys 
            340                 345                 350         


Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Ala Lys Glu Met 
        355                 360                 365             


Leu Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly Thr Pro 
    370                 375                 380                 


His Asn Asn Gln Asp Ile Ile Leu Lys Arg Ala Ala Asp Ile Ala Glu 
385                 390                 395                 400 


Ala Leu Tyr Ser Val Pro Arg Asn Pro Ser Gln Leu Pro Ala Leu Ser 
                405                 410                 415     


Ser Ser Pro Ala His Ser Gly Met Met Gly Ile Asn Ser Tyr Gly Ser 
            420                 425                 430         


Gln Leu Gly Val Ser Ile Ser Glu Ser Thr Gln Gly Asn Asn Gln Gly 
        435                 440                 445             


Tyr Ile Arg Asn Thr Ser Ser Ile Ser Pro Arg Gly Tyr Ser Ser Ser 
    450                 455                 460                 


Ser Thr Pro Gln Gln Ser Asn Tyr Ser Thr Ser Ser Asn Ser Met Asn 
465                 470                 475                 480 


Gly Tyr Ser Asn Val Pro Met Ala Asn Leu Gly Val Pro Gly Ser Pro 
                485                 490                 495     


Gly Phe Leu Asn Gly Ser Pro Thr Gly Ser Pro Tyr Gly Ile Met Ser 
            500                 505                 510         


Ser Ser Pro Thr Val Gly Ser Ser Ser Thr Ser Ser Ile Leu Pro Phe 
        515                 520                 525             


Ser Ser Ser Val Phe Pro Ala Val Lys Gln Lys Ser Ala Phe Ala Pro 
    530                 535                 540                 


Val Ile Arg Pro Gln Gly Ser Pro Ser Pro Ala Cys Ser Ser Gly Asn 
545                 550                 555                 560 


Gly Asn Gly Phe Arg Ala Met Thr Gly Leu Val Val Pro Pro Met 
                565                 570                 575 


<210>  3364
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBF3__Homo_sapiens__NP_001005463

<400>  3364

Met Phe Gly Ile Gln Glu Asn Ile Pro Arg Gly Gly Thr Thr Met Lys 
1               5                   10                  15      


Glu Glu Pro Leu Gly Ser Gly Met Asn Pro Val Arg Ser Trp Met His 
            20                  25                  30          


Thr Ala Gly Val Val Asp Ala Asn Thr Ala Ala Gln Ser Gly Val Gly 
        35                  40                  45              


Leu Ala Arg Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys 
    50                  55                  60                  


Ser Asn Phe Phe His Phe Val Leu Ala Leu Tyr Asp Arg Gln Gly Gln 
65                  70                  75                  80  


Pro Val Glu Ile Glu Arg Thr Ala Phe Val Asp Phe Val Glu Lys Glu 
                85                  90                  95      


Lys Glu Pro Asn Asn Glu Lys Thr Asn Asn Gly Ile His Tyr Lys Leu 
            100                 105                 110         


Gln Leu Leu Tyr Ser Asn Gly Val Arg Thr Glu Gln Asp Leu Tyr Val 
        115                 120                 125             


Arg Leu Ile Asp Ser Met Thr Lys Gln Ala Ile Val Tyr Glu Gly Gln 
    130                 135                 140                 


Asp Lys Asn Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Ile Met 
145                 150                 155                 160 


Cys Ser Arg Cys Cys Asp Lys Lys Ser Cys Gly Asn Arg Asn Glu Thr 
                165                 170                 175     


Pro Ser Asp Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu 
            180                 185                 190         


Lys Cys Asn Gln Asn Cys Leu Lys Asn Ala Gly Asn Pro Arg Asp Met 
        195                 200                 205             


Arg Arg Phe Gln Val Val Val Ser Thr Thr Val Asn Val Asp Gly His 
    210                 215                 220                 


Val Leu Ala Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His 
225                 230                 235                 240 


Gly Arg Arg Ala Arg Arg Leu Asp Pro Ser Glu Ala Thr Pro Cys Ile 
                245                 250                 255     


Lys Ala Ile Ser Pro Ser Glu Gly Trp Thr Thr Gly Gly Ala Thr Val 
            260                 265                 270         


Ile Ile Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Val Phe Gly 
        275                 280                 285             


Thr Met Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val 
    290                 295                 300                 


Gln Thr Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser 
305                 310                 315                 320 


Tyr Lys Ser Lys Gln Phe Cys Lys Gly Ala Pro Gly Arg Phe Val Tyr 
                325                 330                 335     


Thr Ala Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln 
            340                 345                 350         


Lys Val Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Pro Lys Glu 
        355                 360                 365             


Val Leu Leu Lys Arg Ala Ala Asp Leu Val Glu Ala Leu Tyr Gly Met 
    370                 375                 380                 


Pro His Asn Asn Gln Glu Ile Ile Leu Lys Arg Ala Ala Asp Ile Ala 
385                 390                 395                 400 


Glu Ala Leu Tyr Ser Val Pro Arg Asn His Asn Gln Ile Pro Thr Leu 
                405                 410                 415     


Gly Asn Asn Pro Ala His Thr Gly Met Met Gly Val Asn Ser Phe Ser 
            420                 425                 430         


Ser Gln Leu Ala Val Asn Val Ser Glu Thr Ser Gln Ala Asn Asp Gln 
        435                 440                 445             


Val Gly Tyr Ser Arg Asn Thr Ser Ser Val Ser Pro Arg Gly Tyr Val 
    450                 455                 460                 


Pro Ser Ser Thr Pro Gln Gln Ser Asn Tyr Asn Thr Val Ser Thr Ser 
465                 470                 475                 480 


Met Asn Gly Tyr Gly Ser Gly Ala Met Ala Ser Leu Gly Val Pro Gly 
                485                 490                 495     


Ser Pro Gly Phe Leu Asn Gly Ser Ser Ala Asn Ser Pro Tyr Gly Met 
            500                 505                 510         


Lys Gln Lys Ser Ala Phe Ala Pro Val Val Arg Pro Gln Ala Ser Pro 
        515                 520                 525             


Pro Pro Ser Cys Thr Ser Ala Asn Gly Asn Gly Leu Gln Ala Met Ser 
    530                 535                 540                 


Gly Leu Val Val Pro Pro Met 
545                 550     


<210>  3365
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBF4__Homo_sapiens__NP_001103984

<400>  3365

Met Asp Ala Leu Pro Arg Ser Gly Leu Asn Leu Lys Glu Glu Pro Leu 
1               5                   10                  15      


Leu Pro Ala Gly Leu Gly Ser Val Arg Ser Trp Met Gln Gly Ala Gly 
            20                  25                  30          


Ile Leu Asp Ala Ser Thr Ala Ala Gln Ser Gly Val Gly Leu Ala Arg 
        35                  40                  45              


Ala His Phe Glu Lys Gln Pro Pro Ser Asn Leu Arg Lys Ser Asn Phe 
    50                  55                  60                  


Phe His Phe Val Leu Ala Met Tyr Asp Arg Gln Gly Gln Pro Val Glu 
65                  70                  75                  80  


Val Glu Arg Thr Ala Phe Ile Asp Phe Val Glu Lys Asp Arg Glu Pro 
                85                  90                  95      


Gly Ala Glu Lys Thr Asn Asn Gly Ile His Tyr Arg Leu Arg Leu Val 
            100                 105                 110         


Tyr Asn Asn Gly Leu Arg Thr Glu Gln Asp Leu Tyr Val Arg Leu Ile 
        115                 120                 125             


Asp Ser Met Ser Lys Gln Ala Ile Ile Tyr Glu Gly Gln Asp Lys Asn 
    130                 135                 140                 


Pro Glu Met Cys Arg Val Leu Leu Thr His Glu Ile Met Cys Ser Arg 
145                 150                 155                 160 


Cys Cys Asp Arg Lys Ser Cys Gly Asn Arg Asn Glu Thr Pro Ser Asp 
                165                 170                 175     


Pro Val Ile Ile Asp Arg Phe Phe Leu Lys Phe Phe Leu Lys Cys Asn 
            180                 185                 190         


Gln Asn Cys Leu Lys Asn Ala Gly Asn Pro Arg Asp Met Arg Arg Phe 
        195                 200                 205             


Gln Val Val Val Ser Thr Thr Val Ser Val Asp Gly His Val Leu Ala 
    210                 215                 220                 


Val Ser Asp Asn Met Phe Val His Asn Asn Ser Lys His Gly Arg Arg 
225                 230                 235                 240 


Ala Arg Arg Leu Asp Pro Ser Glu Ala Ala Thr Pro Cys Ile Lys Ala 
                245                 250                 255     


Ile Ser Pro Gly Glu Gly Trp Thr Thr Gly Gly Ala Thr Val Ile Val 
            260                 265                 270         


Ile Gly Asp Asn Phe Phe Asp Gly Leu Gln Val Val Phe Gly Asn Val 
        275                 280                 285             


Leu Val Trp Ser Glu Leu Ile Thr Pro His Ala Ile Arg Val Gln Thr 
    290                 295                 300                 


Pro Pro Arg His Ile Pro Gly Val Val Glu Val Thr Leu Ser Tyr Lys 
305                 310                 315                 320 


Ser Lys Gln Phe Cys Lys Gly Cys Pro Gly Arg Phe Val Tyr Thr Ala 
                325                 330                 335     


Leu Asn Glu Pro Thr Ile Asp Tyr Gly Phe Gln Arg Leu Gln Lys Val 
            340                 345                 350         


Ile Pro Arg His Pro Gly Asp Pro Glu Arg Leu Pro Lys Glu Val Leu 
        355                 360                 365             


Leu Lys Arg Ala Ala Asp Leu Ala Glu Ala Leu Tyr Gly Val Pro Gly 
    370                 375                 380                 


Ser Asn Gln Glu Leu Leu Leu Lys Arg Ala Ala Asp Val Ala Glu Ala 
385                 390                 395                 400 


Leu Tyr Ser Thr Pro Arg Ala Pro Gly Pro Leu Ala Pro Leu Ala Pro 
                405                 410                 415     


Ser His Pro His Pro Ala Val Val Gly Ile Asn Ala Phe Ser Ser Pro 
            420                 425                 430         


Leu Ala Ile Ala Val Gly Asp Ala Thr Pro Gly Pro Glu Pro Gly Tyr 
        435                 440                 445             


Ala Arg Ser Cys Ser Ser Ala Ser Pro Arg Gly Phe Ala Pro Ser Pro 
    450                 455                 460                 


Gly Ser Gln Gln Ser Gly Tyr Gly Gly Gly Leu Gly Ala Gly Leu Gly 
465                 470                 475                 480 


Gly Tyr Gly Ala Pro Gly Val Ala Gly Leu Gly Val Pro Gly Ser Pro 
                485                 490                 495     


Ser Phe Leu Asn Gly Ser Thr Ala Thr Ser Pro Phe Ala Ile Met Pro 
            500                 505                 510         


Ser Ser Pro Pro Leu Ala Ala Ala Ser Ser Met Ser Leu Pro Ala Ala 
        515                 520                 525             


Ala Pro Thr Thr Ser Val Phe Ser Phe Ser Pro Val Asn Met Ile Ser 
    530                 535                 540                 


Ala Val Lys Gln Arg Ser Ala Phe Ala Pro Val Leu Arg Pro Pro Ser 
545                 550                 555                 560 


Ser Pro Pro Gln Ala Cys Pro Arg Ala His Gly Glu Gly Leu Pro Asp 
                565                 570                 575     


Gln Ser Phe Glu Asp Ser Asp Lys Phe His Ser Pro Ala Arg Gly Leu 
            580                 585                 590         


Gln Gly Leu Ala Tyr Ser 
        595             


<210>  3366
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBI3__Homo_sapiens__NP_005746

<400>  3366

Met Thr Pro Gln Leu Leu Leu Ala Leu Val Leu Trp Ala Ser Cys Pro 
1               5                   10                  15      


Pro Cys Ser Gly Arg Lys Gly Pro Pro Ala Ala Leu Thr Leu Pro Arg 
            20                  25                  30          


Val Gln Cys Arg Ala Ser Arg Tyr Pro Ile Ala Val Asp Cys Ser Trp 
        35                  40                  45              


Thr Leu Pro Pro Ala Pro Asn Ser Thr Ser Pro Val Ser Phe Ile Ala 
    50                  55                  60                  


Thr Tyr Arg Leu Gly Met Ala Ala Arg Gly His Ser Trp Pro Cys Leu 
65                  70                  75                  80  


Gln Gln Thr Pro Thr Ser Thr Ser Cys Thr Ile Thr Asp Val Gln Leu 
                85                  90                  95      


Phe Ser Met Ala Pro Tyr Val Leu Asn Val Thr Ala Val His Pro Trp 
            100                 105                 110         


Gly Ser Ser Ser Ser Phe Val Pro Phe Ile Thr Glu His Ile Ile Lys 
        115                 120                 125             


Pro Asp Pro Pro Glu Gly Val Arg Leu Ser Pro Leu Ala Glu Arg Gln 
    130                 135                 140                 


Leu Gln Val Gln Trp Glu Pro Pro Gly Ser Trp Pro Phe Pro Glu Ile 
145                 150                 155                 160 


Phe Ser Leu Lys Tyr Trp Ile Arg Tyr Lys Arg Gln Gly Ala Ala Arg 
                165                 170                 175     


Phe His Arg Val Gly Pro Ile Glu Ala Thr Ser Phe Ile Leu Arg Ala 
            180                 185                 190         


Val Arg Pro Arg Ala Arg Tyr Tyr Val Gln Val Ala Ala Gln Asp Leu 
        195                 200                 205             


Thr Asp Tyr Gly Glu Leu Ser Asp Trp Ser Leu Pro Ala Thr Ala Thr 
    210                 215                 220                 


Met Ser Leu Gly Lys 
225                 


<210>  3367
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBP__Homo_sapiens__NP_006570

<400>  3367

Met Thr Thr Asn Ala Gly Pro Leu His Pro Tyr Trp Pro Gln His Leu 
1               5                   10                  15      


Arg Leu Asp Asn Phe Val Pro Asn Asp Arg Pro Thr Trp His Ile Leu 
            20                  25                  30          


Ala Gly Leu Phe Ser Val Thr Gly Val Leu Val Val Thr Thr Trp Leu 
        35                  40                  45              


Leu Ser Gly Arg Ala Ala Val Val Pro Leu Gly Thr Trp Arg Arg Leu 
    50                  55                  60                  


Ser Leu Cys Trp Phe Ala Val Cys Gly Phe Ile His Leu Val Ile Glu 
65                  70                  75                  80  


Gly Trp Phe Val Leu Tyr Tyr Glu Asp Leu Leu Gly Asp Gln Ala Phe 
                85                  90                  95      


Leu Ser Gln Leu Trp Lys Glu Tyr Ala Lys Gly Asp Ser Arg Tyr Ile 
            100                 105                 110         


Leu Gly Asp Asn Phe Thr Val Cys Met Glu Thr Ile Thr Ala Cys Leu 
        115                 120                 125             


Trp Gly Pro Leu Ser Leu Trp Val Val Ile Ala Phe Leu Arg Gln His 
    130                 135                 140                 


Pro Leu Arg Phe Ile Leu Gln Leu Val Val Ser Val Gly Gln Ile Tyr 
145                 150                 155                 160 


Gly Asp Val Leu Tyr Phe Leu Thr Glu His Arg Asp Gly Phe Gln His 
                165                 170                 175     


Gly Glu Leu Gly His Pro Leu Tyr Phe Trp Phe Tyr Phe Val Phe Met 
            180                 185                 190         


Asn Ala Leu Trp Leu Val Leu Pro Gly Val Leu Val Leu Asp Ala Val 
        195                 200                 205             


Lys His Leu Thr His Ala Gln Ser Thr Leu Asp Ala Lys Ala Thr Lys 
    210                 215                 220                 


Ala Lys Ser Lys Lys Asn 
225                 230 


<210>  3368
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBPL__Homo_sapiens__NP_001265565

<400>  3368

Met Gly Ala Glu Trp Glu Leu Gly Ala Glu Ala Gly Gly Ser Leu Leu 
1               5                   10                  15      


Leu Cys Ala Ala Leu Leu Ala Ala Gly Cys Ala Leu Gly Leu Arg Leu 
            20                  25                  30          


Gly Arg Gly Gln Gly Ala Ala Asp Arg Gly Ala Leu Ile Trp Leu Cys 
        35                  40                  45              


Tyr Asp Ala Leu Val His Phe Ala Leu Glu Gly Pro Phe Val Tyr Leu 
    50                  55                  60                  


Ser Leu Val Gly Asn Val Ala Asn Ser Asp Gly Leu Ile Ala Ser Leu 
65                  70                  75                  80  


Trp Lys Glu Tyr Gly Lys Ala Asp Ala Arg Trp Val Tyr Phe Asp Pro 
                85                  90                  95      


Thr Ile Val Ser Val Glu Ile Leu Thr Val Ala Leu Asp Gly Ser Leu 
            100                 105                 110         


Ala Leu Phe Leu Ile Tyr Ala Ile Val Lys Glu Lys Tyr Tyr Arg Asp 
        115                 120                 125             


Arg Val Ala Trp Gly Glu 
    130                 


<210>  3369
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECD__Homo_sapiens__NP_001129224

<400>  3369

Met Glu Glu Thr Met Lys Leu Ala Thr Met Glu Asp Thr Val Glu Tyr 
1               5                   10                  15      


Cys Leu Phe Leu Ile Pro Asp Glu Ser Arg Asp Ser Asp Lys His Lys 
            20                  25                  30          


Glu Ile Leu Gln Lys Tyr Ile Glu Arg Ile Ile Thr Arg Phe Ala Pro 
        35                  40                  45              


Met Leu Val Pro Tyr Ile Trp Gln Asn Gln Pro Phe Asn Leu Lys Tyr 
    50                  55                  60                  


Lys Pro Gly Lys Gly Gly Val Pro Ala His Met Phe Gly Val Thr Lys 
65                  70                  75                  80  


Phe Gly Asp Asn Ile Glu Asp Glu Trp Phe Ile Val Tyr Val Ile Lys 
                85                  90                  95      


Gln Ile Thr Lys Glu Phe Pro Glu Leu Val Ala Arg Ile Glu Asp Asn 
            100                 105                 110         


Asp Gly Glu Phe Leu Leu Ile Glu Ala Ala Asp Phe Leu Pro Lys Trp 
        115                 120                 125             


Leu Asp Pro Glu Asn Ser Thr Asn Arg Val Phe Phe Cys His Gly Glu 
    130                 135                 140                 


Leu Cys Ile Ile Pro Ala Pro Arg Lys Ser Gly Ala Glu Ser Trp Leu 
145                 150                 155                 160 


Pro Thr Thr Pro Pro Thr Ile Pro Gln Ala Leu Asn Ile Ile Thr Ala 
                165                 170                 175     


His Ser Glu Lys Ile Leu Ala Ser Glu Ser Ile Arg Ala Ala Val Asn 
            180                 185                 190         


Arg Arg Ile Arg Gly Tyr Pro Glu Lys Ile Gln Ala Ser Leu His Arg 
        195                 200                 205             


Ala His Cys Phe Leu Pro Ala Gly Ile Val Ala Val Leu Lys Gln Arg 
    210                 215                 220                 


Pro Arg Leu Val Ala Ala Ala Val Gln Ala Phe Tyr Leu Arg Asp Pro 
225                 230                 235                 240 


Ile Asp Leu Arg Ala Cys Arg Val Phe Lys Thr Phe Leu Pro Glu Thr 
                245                 250                 255     


Arg Ile Met Thr Ser Val Thr Phe Thr Lys Cys Leu Tyr Ala Gln Leu 
            260                 265                 270         


Val Gln Gln Arg Phe Val Pro Asp Arg Arg Ser Gly Tyr Arg Leu Pro 
        275                 280                 285             


Pro Pro Ser Asp Pro Gln Tyr Arg Ala His Glu Leu Gly Met Lys Leu 
    290                 295                 300                 


Ala His Gly Phe Glu Ile Leu Cys Ser Lys Cys Ser Pro His Phe Ser 
305                 310                 315                 320 


Asp Cys Lys Lys Ser Leu Val Thr Ala Ser Pro Leu Trp Ala Ser Phe 
                325                 330                 335     


Leu Glu Ser Leu Lys Lys Asn Asp Tyr Phe Lys Gly Leu Ile Glu Gly 
            340                 345                 350         


Ser Ala Gln Tyr Arg Glu Arg Leu Glu Met Ala Glu Asn Tyr Phe Gln 
        355                 360                 365             


Leu Ser Val Asp Trp Pro Glu Arg Leu Glu Val Gln Trp Arg Asp Pro 
    370                 375                 380                 


Gly Leu Leu Gln Ala Pro Pro Pro Gly Phe Thr Pro Phe Ile Cys Leu 
385                 390                 395                 400 


Ser Leu Leu Ser Thr Trp Asp Asn Ser Ser Leu Ala Met Ser Pro Gly 
                405                 410                 415     


Glu Glu Ile Leu Thr Leu Leu Gln Thr Ile Pro Phe Asp Ile Glu Asp 
            420                 425                 430         


Leu Lys Lys Glu Ala Ala Asn Leu Pro Pro Glu Asp Asp Asp Gln Trp 
        435                 440                 445             


Leu Asp Leu Ser Pro Asp Gln Leu Asp Gln Leu Leu Gln Glu Ala Val 
    450                 455                 460                 


Gly Lys Lys Glu Ser Glu Ser Val Ser Lys Glu Glu Lys Glu Gln Asn 
465                 470                 475                 480 


Tyr Asp Leu Thr Glu Val Ser Glu Ser Met Lys Ala Phe Ile Ser Lys 
                485                 490                 495     


Val Ser Thr His Lys Gly Ala Glu Leu Pro Arg Glu Pro Ser Glu Ala 
            500                 505                 510         


Pro Ile Thr Phe Asp Ala Asp Ser Phe Leu Asn Tyr Phe Asp Lys Ile 
        515                 520                 525             


Leu Gly Pro Arg Pro Asn Glu Ser Asp Ser Asp Asp Leu Asp Asp Glu 
    530                 535                 540                 


Asp Phe Glu Cys Leu Asp Ser Asp Asp Asp Leu Asp Phe Glu Thr His 
545                 550                 555                 560 


Glu Pro Gly Glu Glu Ala Ser Leu Lys Gly Thr Leu Asp Asn Leu Lys 
                565                 570                 575     


Ser Tyr Met Ala Gln Met Asp Gln Glu Leu Ala His Thr Cys Ile Ser 
            580                 585                 590         


Lys Ser Phe Thr Thr Arg Asn Gln Val Glu Pro Val Ser Gln Thr Thr 
        595                 600                 605             


Asp Asn Asn Ser Asp Glu Glu Asp Ser Gly Thr Gly Glu Ser Val Met 
    610                 615                 620                 


Ala Pro Val Asp Val Asp Leu Asn Leu Val Ser Asn Ile Leu Glu Ser 
625                 630                 635                 640 


Tyr Ser Ser Gln Ala Gly Leu Ala Gly Pro Ala Ser Asn Leu Leu Gln 
                645                 650                 655     


Ser Met Gly Val Gln Leu Pro Asp Asn Thr Asp His Arg Pro Thr Ser 
            660                 665                 670         


Lys Pro Thr Lys Asn 
        675         


<210>  3370
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECE2__Homo_sapiens__NP_001032401

<400>  3370

Met Asn Val Ala Leu Gln Glu Leu Gly Ala Gly Ser Asn Val Gly Phe 
1               5                   10                  15      


Gln Lys Gly Thr Arg Gln Leu Leu Gly Ser Arg Thr Gln Leu Glu Leu 
            20                  25                  30          


Val Leu Ala Gly Ala Ser Leu Leu Leu Ala Ala Leu Leu Leu Gly Cys 
        35                  40                  45              


Leu Val Ala Leu Gly Val Gln Tyr His Arg Asp Pro Ser His Ser Thr 
    50                  55                  60                  


Cys Leu Thr Glu Ala Cys Ile Arg Val Ala Gly Lys Ile Leu Glu Ser 
65                  70                  75                  80  


Leu Asp Arg Gly Val Ser Pro Cys Glu Asp Phe Tyr Gln Phe Ser Cys 
                85                  90                  95      


Gly Gly Trp Ile Arg Arg Asn Pro Leu Pro Asp Gly Arg Ser Arg Trp 
            100                 105                 110         


Asn Thr Phe Asn Ser Leu Trp Asp Gln Asn Gln Ala Ile Leu Lys His 
        115                 120                 125             


Leu Leu Glu Asn Thr Thr Phe Asn Ser Ser Ser Glu Ala Glu Gln Lys 
    130                 135                 140                 


Thr Gln Arg Phe Tyr Leu Ser Cys Leu Gln Val Glu Arg Ile Glu Glu 
145                 150                 155                 160 


Leu Gly Ala Gln Pro Leu Arg Asp Leu Ile Glu Lys Ile Gly Gly Trp 
                165                 170                 175     


Asn Ile Thr Gly Pro Trp Asp Gln Asp Asn Phe Met Glu Val Leu Lys 
            180                 185                 190         


Ala Val Ala Gly Thr Tyr Arg Ala Thr Pro Phe Phe Thr Val Tyr Ile 
        195                 200                 205             


Ser Ala Asp Ser Lys Ser Ser Asn Ser Asn Val Ile Gln Val Asp Gln 
    210                 215                 220                 


Ser Gly Leu Phe Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Arg Thr Ala 
225                 230                 235                 240 


Asn Glu Lys Val Leu Thr Ala Tyr Leu Asp Tyr Met Glu Glu Leu Gly 
                245                 250                 255     


Met Leu Leu Gly Gly Arg Pro Thr Ser Thr Arg Glu Gln Met Gln Gln 
            260                 265                 270         


Val Leu Glu Leu Glu Ile Gln Leu Ala Asn Ile Thr Val Pro Gln Asp 
        275                 280                 285             


Gln Arg Arg Asp Glu Glu Lys Ile Tyr His Lys Met Ser Ile Ser Glu 
    290                 295                 300                 


Leu Gln Ala Leu Ala Pro Ser Met Asp Trp Leu Glu Phe Leu Ser Phe 
305                 310                 315                 320 


Leu Leu Ser Pro Leu Glu Leu Ser Asp Ser Glu Pro Val Val Val Tyr 
                325                 330                 335     


Gly Met Asp Tyr Leu Gln Gln Val Ser Glu Leu Ile Asn Arg Thr Glu 
            340                 345                 350         


Pro Ser Ile Leu Asn Asn Tyr Leu Ile Trp Asn Leu Val Gln Lys Thr 
        355                 360                 365             


Thr Ser Ser Leu Asp Arg Arg Phe Glu Ser Ala Gln Glu Lys Leu Leu 
    370                 375                 380                 


Glu Thr Leu Tyr Gly Thr Lys Lys Ser Cys Val Pro Arg Trp Gln Thr 
385                 390                 395                 400 


Cys Ile Ser Asn Thr Asp Asp Ala Leu Gly Phe Ala Leu Gly Ser Leu 
                405                 410                 415     


Phe Val Lys Ala Thr Phe Asp Arg Gln Ser Lys Glu Ile Ala Glu Gly 
            420                 425                 430         


Met Ile Ser Glu Ile Arg Thr Ala Phe Glu Glu Ala Leu Gly Gln Leu 
        435                 440                 445             


Val Trp Met Asp Glu Lys Thr Arg Gln Ala Ala Lys Glu Lys Ala Asp 
    450                 455                 460                 


Ala Ile Tyr Asp Met Ile Gly Phe Pro Asp Phe Ile Leu Glu Pro Lys 
465                 470                 475                 480 


Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser Phe 
                485                 490                 495     


Phe Gln Asn Met Leu Asn Leu Tyr Asn Phe Ser Ala Lys Val Met Ala 
            500                 505                 510         


Asp Gln Leu Arg Lys Pro Pro Ser Arg Asp Gln Trp Ser Met Thr Pro 
        515                 520                 525             


Gln Thr Val Asn Ala Tyr Tyr Leu Pro Thr Lys Asn Glu Ile Val Phe 
    530                 535                 540                 


Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Ala Arg Asn His Pro Lys 
545                 550                 555                 560 


Ala Leu Asn Phe Gly Gly Ile Gly Val Val Met Gly His Glu Leu Thr 
                565                 570                 575     


His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Glu Gly Asn Leu 
            580                 585                 590         


Arg Pro Trp Trp Gln Asn Glu Ser Leu Ala Ala Phe Arg Asn His Thr 
        595                 600                 605             


Ala Cys Met Glu Glu Gln Tyr Asn Gln Tyr Gln Val Asn Gly Glu Arg 
    610                 615                 620                 


Leu Asn Gly Arg Gln Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly 
625                 630                 635                 640 


Leu Lys Ala Ala Tyr Asn Ala Tyr Lys Ala Trp Leu Arg Lys His Gly 
                645                 650                 655     


Glu Glu Gln Gln Leu Pro Ala Val Gly Leu Thr Asn His Gln Leu Phe 
            660                 665                 670         


Phe Val Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro Glu Ser 
        675                 680                 685             


Ser His Glu Gly Leu Val Thr Asp Pro His Ser Pro Ala Arg Phe Arg 
    690                 695                 700                 


Val Leu Gly Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly 
705                 710                 715                 720 


Cys Pro Val Gly Ser Pro Met Asn Pro Gly Gln Leu Cys Glu Val Trp 
                725                 730                 735     


<210>  3371
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECEL1__Homo_sapiens__NP_001277716

<400>  3371

Met Glu Pro Pro Tyr Ser Leu Thr Ala His Tyr Asp Glu Phe Gln Glu 
1               5                   10                  15      


Val Lys Tyr Val Ser Arg Cys Gly Ala Gly Gly Ala Arg Gly Ala Ser 
            20                  25                  30          


Leu Pro Pro Gly Phe Pro Leu Gly Ala Ala Arg Ser Ala Thr Gly Ala 
        35                  40                  45              


Arg Ser Gly Leu Pro Arg Trp Asn Arg Arg Glu Val Cys Leu Leu Ser 
    50                  55                  60                  


Gly Leu Val Phe Ala Ala Gly Leu Cys Ala Ile Leu Ala Ala Met Leu 
65                  70                  75                  80  


Ala Leu Lys Tyr Leu Gly Pro Val Ala Ala Gly Gly Gly Ala Cys Pro 
                85                  90                  95      


Glu Gly Cys Pro Glu Arg Lys Ala Phe Ala Arg Ala Ala Arg Phe Leu 
            100                 105                 110         


Ala Ala Asn Leu Asp Ala Ser Ile Asp Pro Cys Gln Asp Phe Tyr Ser 
        115                 120                 125             


Phe Ala Cys Gly Gly Trp Leu Arg Arg His Ala Ile Pro Asp Asp Lys 
    130                 135                 140                 


Leu Thr Tyr Gly Thr Ile Ala Ala Ile Gly Glu Gln Asn Glu Glu Arg 
145                 150                 155                 160 


Leu Arg Arg Leu Leu Ala Arg Pro Gly Gly Gly Pro Gly Gly Ala Ala 
                165                 170                 175     


Gln Arg Lys Val Arg Ala Phe Phe Arg Ser Cys Leu Asp Met Arg Glu 
            180                 185                 190         


Ile Glu Arg Leu Gly Pro Arg Pro Met Leu Glu Val Ile Glu Asp Cys 
        195                 200                 205             


Gly Gly Trp Asp Leu Gly Gly Ala Glu Glu Arg Pro Gly Val Ala Ala 
    210                 215                 220                 


Arg Trp Asp Leu Asn Arg Leu Leu Tyr Lys Ala Gln Gly Val Tyr Ser 
225                 230                 235                 240 


Ala Ala Ala Leu Phe Ser Leu Thr Val Ser Leu Asp Asp Arg Asn Ser 
                245                 250                 255     


Ser Arg Tyr Val Ile Arg Ile Asp Gln Asp Gly Leu Thr Leu Pro Glu 
            260                 265                 270         


Arg Thr Leu Tyr Leu Ala Gln Asp Glu Asp Ser Glu Lys Ile Leu Ala 
        275                 280                 285             


Ala Tyr Arg Val Phe Met Glu Arg Val Leu Ser Leu Leu Gly Ala Asp 
    290                 295                 300                 


Ala Val Glu Gln Lys Ala Gln Glu Ile Leu Gln Val Glu Gln Gln Leu 
305                 310                 315                 320 


Ala Asn Ile Thr Val Ser Glu His Asp Asp Leu Arg Arg Asp Val Ser 
                325                 330                 335     


Ser Met Tyr Asn Lys Val Thr Leu Gly Gln Leu Gln Lys Ile Thr Pro 
            340                 345                 350         


His Leu Arg Trp Lys Trp Leu Leu Asp Gln Ile Phe Gln Glu Asp Phe 
        355                 360                 365             


Ser Glu Glu Glu Glu Val Val Leu Leu Ala Thr Asp Tyr Met Gln Gln 
    370                 375                 380                 


Val Ser Gln Leu Ile Arg Ser Thr Pro His Arg Val Leu His Asn Tyr 
385                 390                 395                 400 


Leu Val Trp Arg Val Val Val Val Leu Ser Glu His Leu Ser Pro Pro 
                405                 410                 415     


Phe Arg Glu Ala Leu His Glu Leu Ala Gln Glu Met Glu Gly Ser Asp 
            420                 425                 430         


Lys Pro Gln Glu Leu Ala Arg Val Cys Leu Gly Gln Ala Asn Arg His 
        435                 440                 445             


Phe Gly Met Ala Leu Gly Ala Leu Phe Val His Glu His Phe Ser Ala 
    450                 455                 460                 


Ala Ser Lys Ala Lys Val Gln Gln Leu Val Glu Asp Ile Lys Tyr Ile 
465                 470                 475                 480 


Leu Gly Gln Arg Leu Glu Glu Leu Asp Trp Met Asp Ala Glu Thr Arg 
                485                 490                 495     


Ala Ala Ala Arg Ala Lys Leu Gln Tyr Met Met Val Met Val Gly Tyr 
            500                 505                 510         


Pro Asp Phe Leu Leu Lys Pro Asp Ala Val Asp Lys Glu Tyr Glu Phe 
        515                 520                 525             


Glu Val His Glu Lys Thr Tyr Phe Lys Asn Ile Leu Asn Ser Ile Arg 
    530                 535                 540                 


Phe Ser Ile Gln Leu Ser Val Lys Lys Ile Arg Gln Glu Val Asp Lys 
545                 550                 555                 560 


Trp Leu Leu Pro Pro Gln Ala Leu Asn Ala Tyr Tyr Leu Pro Asn Lys 
                565                 570                 575     


Asn Gln Met Val Phe Pro Ala Gly Ile Leu Gln Pro Thr Leu Tyr Asp 
            580                 585                 590         


Pro Asp Phe Pro Gln Ser Leu Asn Tyr Gly Gly Ile Gly Thr Ile Ile 
        595                 600                 605             


Gly His Glu Leu Thr His Gly Tyr Asp Asp Trp Gly Gly Gln Tyr Asp 
    610                 615                 620                 


Arg Ser Gly Asn Leu Leu His Trp Trp Thr Glu Ala Ser Tyr Ser Arg 
625                 630                 635                 640 


Phe Leu Arg Lys Ala Glu Cys Ile Val Arg Leu Tyr Asp Asn Phe Thr 
                645                 650                 655     


Val Tyr Asn Gln Arg Val Asn Gly Lys His Thr Leu Gly Glu Asn Ile 
            660                 665                 670         


Ala Asp Met Gly Gly Leu Lys Leu Ala Tyr His Ala Tyr Gln Lys Trp 
        675                 680                 685             


Val Arg Glu His Gly Pro Glu His Pro Leu Pro Arg Leu Lys Tyr Thr 
    690                 695                 700                 


His Asp Gln Leu Phe Phe Ile Ala Phe Ala Gln Asn Trp Cys Ile Lys 
705                 710                 715                 720 


Arg Arg Ser Gln Ser Ile Tyr Leu Gln Val Leu Thr Asp Lys His Ala 
                725                 730                 735     


Pro Glu His Tyr Arg Val Leu Gly Ser Val Ser Gln Phe Glu Glu Phe 
            740                 745                 750         


Gly Arg Ala Phe His Cys Pro Lys Asp Ser Pro Met Asn Pro Ala His 
        755                 760                 765             


Lys Cys Ser Val Trp 
    770             


<210>  3372
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECHDC1__Homo_sapiens__NP_001099014

<400>  3372

Met Met Leu Gln Leu Leu Glu Lys Val Ile Glu Leu Glu Asn Trp Thr 
1               5                   10                  15      


Glu Gly Lys Gly Leu Ile Val Arg Gly Ala Lys Asn Thr Phe Ser Ser 
            20                  25                  30          


Gly Ser Asp Leu Asn Ala Val Lys Ser Leu Gly Thr Pro Glu Asp Gly 
        35                  40                  45              


Met Ala Val Cys Met Phe Met Gln Asn Thr Leu Thr Arg Phe Met Arg 
    50                  55                  60                  


Leu Pro Leu Ile Ser Val Ala Leu Val Gln Gly Trp Ala Leu Gly Gly 
65                  70                  75                  80  


Gly Ala Glu Phe Thr Thr Ala Cys Asp Phe Arg Leu Met Thr Pro Glu 
                85                  90                  95      


Ser Lys Ile Arg Phe Val His Lys Glu Met Gly Ile Ile Pro Ser Trp 
            100                 105                 110         


Gly Gly Thr Thr Arg Leu Val Glu Ile Ile Gly Ser Arg Gln Ala Leu 
        115                 120                 125             


Lys Val Leu Ser Gly Ala Leu Lys Leu Asp Ser Lys Asn Ala Leu Asn 
    130                 135                 140                 


Ile Gly Met Val Glu Glu Val Leu Gln Ser Ser Asp Glu Thr Lys Ser 
145                 150                 155                 160 


Leu Glu Glu Ala Gln Glu Trp Leu Lys Gln Phe Ile Gln Gly Pro Pro 
                165                 170                 175     


Glu Val Ile Arg Ala Leu Lys Lys Ser Val Cys Ser Gly Arg Glu Leu 
            180                 185                 190         


Tyr Leu Glu Glu Ala Leu Gln Asn Glu Arg Asp Leu Leu Gly Thr Val 
        195                 200                 205             


Trp Gly Gly Pro Ala Asn Leu Glu Ala Ile Ala Lys Lys Gly Lys Phe 
    210                 215                 220                 


Asn Lys 
225     


<210>  3373
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECHDC3__Homo_sapiens__NP_078969

<400>  3373

Met Ala Ala Val Ala Val Leu Arg Ala Phe Gly Ala Ser Gly Pro Met 
1               5                   10                  15      


Cys Leu Arg Arg Gly Pro Trp Ala Gln Leu Pro Ala Arg Phe Cys Ser 
            20                  25                  30          


Arg Asp Pro Ala Gly Ala Gly Arg Arg Glu Ser Glu Pro Arg Pro Thr 
        35                  40                  45              


Ser Ala Arg Gln Leu Asp Gly Ile Arg Asn Ile Val Leu Ser Asn Pro 
    50                  55                  60                  


Lys Lys Arg Asn Thr Leu Ser Leu Ala Met Leu Lys Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Ile Leu His Asp Ala Asp Ser Asn Asp Leu Lys Val Ile Ile Ile 
                85                  90                  95      


Ser Ala Glu Gly Pro Val Phe Ser Ser Gly His Asp Leu Lys Glu Leu 
            100                 105                 110         


Thr Glu Glu Gln Gly Arg Asp Tyr His Ala Glu Val Phe Gln Thr Cys 
        115                 120                 125             


Ser Lys Val Met Met His Ile Arg Asn His Pro Val Pro Val Ile Ala 
    130                 135                 140                 


Met Val Asn Gly Leu Ala Thr Ala Ala Gly Cys Gln Leu Val Ala Ser 
145                 150                 155                 160 


Cys Asp Ile Ala Val Ala Ser Asp Lys Ser Ser Phe Ala Thr Pro Gly 
                165                 170                 175     


Val Asn Val Gly Leu Phe Cys Ser Thr Pro Gly Val Ala Leu Ala Arg 
            180                 185                 190         


Ala Val Pro Arg Lys Val Ala Leu Glu Met Leu Phe Thr Gly Glu Pro 
        195                 200                 205             


Ile Ser Ala Gln Glu Ala Leu Leu His Gly Leu Leu Ser Lys Val Val 
    210                 215                 220                 


Pro Glu Ala Glu Leu Gln Glu Glu Thr Met Arg Ile Ala Arg Lys Ile 
225                 230                 235                 240 


Ala Ser Leu Ser Arg Pro Val Val Ser Leu Gly Lys Ala Thr Phe Tyr 
                245                 250                 255     


Lys Gln Leu Pro Gln Asp Leu Gly Thr Ala Tyr Tyr Leu Thr Ser Gln 
            260                 265                 270         


Ala Met Val Asp Asn Leu Ala Leu Arg Asp Gly Gln Glu Gly Ile Thr 
        275                 280                 285             


Ala Phe Leu Gln Lys Arg Lys Pro Val Trp Ser His Glu Pro Val 
    290                 295                 300             


<210>  3374
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECHS1__Homo_sapiens__NP_004083

<400>  3374

Met Ala Ala Leu Arg Val Leu Leu Ser Cys Val Arg Gly Pro Leu Arg 
1               5                   10                  15      


Pro Pro Val Arg Cys Pro Ala Trp Arg Pro Phe Ala Ser Gly Ala Asn 
            20                  25                  30          


Phe Glu Tyr Ile Ile Ala Glu Lys Arg Gly Lys Asn Asn Thr Val Gly 
        35                  40                  45              


Leu Ile Gln Leu Asn Arg Pro Lys Ala Leu Asn Ala Leu Cys Asp Gly 
    50                  55                  60                  


Leu Ile Asp Glu Leu Asn Gln Ala Leu Lys Thr Phe Glu Glu Asp Pro 
65                  70                  75                  80  


Ala Val Gly Ala Ile Val Leu Thr Gly Gly Asp Lys Ala Phe Ala Ala 
                85                  90                  95      


Gly Ala Asp Ile Lys Glu Met Gln Asn Leu Ser Phe Gln Asp Cys Tyr 
            100                 105                 110         


Ser Ser Lys Phe Leu Lys His Trp Asp His Leu Thr Gln Val Lys Lys 
        115                 120                 125             


Pro Val Ile Ala Ala Val Asn Gly Tyr Ala Phe Gly Gly Gly Cys Glu 
    130                 135                 140                 


Leu Ala Met Met Cys Asp Ile Ile Tyr Ala Gly Glu Lys Ala Gln Phe 
145                 150                 155                 160 


Ala Gln Pro Glu Ile Leu Ile Gly Thr Ile Pro Gly Ala Gly Gly Thr 
                165                 170                 175     


Gln Arg Leu Thr Arg Ala Val Gly Lys Ser Leu Ala Met Glu Met Val 
            180                 185                 190         


Leu Thr Gly Asp Arg Ile Ser Ala Gln Asp Ala Lys Gln Ala Gly Leu 
        195                 200                 205             


Val Ser Lys Ile Cys Pro Val Glu Thr Leu Val Glu Glu Ala Ile Gln 
    210                 215                 220                 


Cys Ala Glu Lys Ile Ala Ser Asn Ser Lys Ile Val Val Ala Met Ala 
225                 230                 235                 240 


Lys Glu Ser Val Asn Ala Ala Phe Glu Met Thr Leu Thr Glu Gly Ser 
                245                 250                 255     


Lys Leu Glu Lys Lys Leu Phe Tyr Ser Thr Phe Ala Thr Asp Asp Arg 
            260                 265                 270         


Lys Glu Gly Met Thr Ala Phe Val Glu Lys Arg Lys Ala Asn Phe Lys 
        275                 280                 285             


Asp Gln 
    290 


<210>  3375
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECI1__Homo_sapiens__NP_001171500

<400>  3375

Met Ala Leu Val Ala Ser Val Arg Val Pro Ala Arg Val Leu Leu Arg 
1               5                   10                  15      


Ala Gly Ala Arg Leu Pro Gly Ala Ala Leu Gly Arg Thr Glu Arg Ala 
            20                  25                  30          


Ala Gly Gly Gly Asp Gly Ala Arg Arg Phe Gly Ser Gln Arg Val Leu 
        35                  40                  45              


Val Glu Pro Asp Ala Gly Ala Gly Val Ala Val Met Lys Phe Lys Asn 
    50                  55                  60                  


Pro Pro Val Asn Ser Leu Ser Leu Glu Phe Leu Thr Glu Leu Val Ile 
65                  70                  75                  80  


Ser Leu Glu Lys Leu Glu Asn Asp Lys Ser Phe Arg Gly Val Ile Leu 
                85                  90                  95      


Thr Ser Asp Arg Pro Gly Val Phe Ser Ala Gly Leu Asp Leu Thr Glu 
            100                 105                 110         


Met Cys Gly Arg Ser Pro Ala His Tyr Ala Gly Tyr Trp Lys Ala Val 
        115                 120                 125             


Gln Glu Leu Trp Leu Arg Leu Tyr Gln Ser Asn Leu Val Leu Val Ser 
    130                 135                 140                 


Ala Ile Asn Gly Ala Cys Pro Ala Gly Gly Cys Leu Val Ala Leu Thr 
145                 150                 155                 160 


Cys Asp Tyr Arg Ile Leu Ala Asp Asn Pro Arg Leu Lys Asp Thr Leu 
                165                 170                 175     


Glu Asn Thr Ile Gly His Arg Ala Ala Glu Arg Ala Leu Gln Leu Gly 
            180                 185                 190         


Leu Leu Phe Pro Pro Ala Glu Ala Leu Gln Val Gly Ile Val Asp Gln 
        195                 200                 205             


Val Val Pro Glu Glu Gln Val Gln Ser Thr Ala Leu Ser Ala Ile Ala 
    210                 215                 220                 


Gln Trp Met Ala Ile Pro Asp His Ala Arg Gln Leu Thr Lys Ala Met 
225                 230                 235                 240 


Met Arg Lys Ala Thr Ala Ser Arg Leu Val Thr Gln Arg Asp Ala Asp 
                245                 250                 255     


Val Gln Asn Phe Val Ser Phe Ile Ser Lys Asp Ser Ile Gln Lys Ser 
            260                 265                 270         


Leu Gln Met Tyr Leu Glu Arg Leu Lys Glu Glu Lys Gly 
        275                 280                 285 


<210>  3376
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECI2__Homo_sapiens__NP_006108

<400>  3376

Met Asn Arg Thr Ala Met Arg Ala Ser Gln Lys Asp Phe Glu Asn Ser 
1               5                   10                  15      


Met Asn Gln Val Lys Leu Leu Lys Lys Asp Pro Gly Asn Glu Val Lys 
            20                  25                  30          


Leu Lys Leu Tyr Ala Leu Tyr Lys Gln Ala Thr Glu Gly Pro Cys Asn 
        35                  40                  45              


Met Pro Lys Pro Gly Val Phe Asp Leu Ile Asn Lys Ala Lys Trp Asp 
    50                  55                  60                  


Ala Trp Asn Ala Leu Gly Ser Leu Pro Lys Glu Ala Ala Arg Gln Asn 
65                  70                  75                  80  


Tyr Val Asp Leu Val Ser Ser Leu Ser Pro Ser Leu Glu Ser Ser Ser 
                85                  90                  95      


Gln Val Glu Pro Gly Thr Asp Arg Lys Ser Thr Gly Phe Glu Thr Leu 
            100                 105                 110         


Val Val Thr Ser Glu Asp Gly Ile Thr Lys Ile Met Phe Asn Arg Pro 
        115                 120                 125             


Lys Lys Lys Asn Ala Ile Asn Thr Glu Met Tyr His Glu Ile Met Arg 
    130                 135                 140                 


Ala Leu Lys Ala Ala Ser Lys Asp Asp Ser Ile Ile Thr Val Leu Thr 
145                 150                 155                 160 


Gly Asn Gly Asp Tyr Tyr Ser Ser Gly Asn Asp Leu Thr Asn Phe Thr 
                165                 170                 175     


Asp Ile Pro Pro Gly Gly Val Glu Glu Lys Ala Lys Asn Asn Ala Val 
            180                 185                 190         


Leu Leu Arg Glu Phe Val Gly Cys Phe Ile Asp Phe Pro Lys Pro Leu 
        195                 200                 205             


Ile Ala Val Val Asn Gly Pro Ala Val Gly Ile Ser Val Thr Leu Leu 
    210                 215                 220                 


Gly Leu Phe Asp Ala Val Tyr Ala Ser Asp Arg Ala Thr Phe His Thr 
225                 230                 235                 240 


Pro Phe Ser His Leu Gly Gln Ser Pro Glu Gly Cys Ser Ser Tyr Thr 
                245                 250                 255     


Phe Pro Lys Ile Met Ser Pro Ala Lys Ala Thr Glu Met Leu Ile Phe 
            260                 265                 270         


Gly Lys Lys Leu Thr Ala Gly Glu Ala Cys Ala Gln Gly Leu Val Thr 
        275                 280                 285             


Glu Val Phe Pro Asp Ser Thr Phe Gln Lys Glu Val Trp Thr Arg Leu 
    290                 295                 300                 


Lys Ala Phe Ala Lys Leu Pro Pro Asn Ala Leu Arg Ile Ser Lys Glu 
305                 310                 315                 320 


Val Ile Arg Lys Arg Glu Arg Glu Lys Leu His Ala Val Asn Ala Glu 
                325                 330                 335     


Glu Cys Asn Val Leu Gln Gly Arg Trp Leu Ser Asp Glu Cys Thr Asn 
            340                 345                 350         


Ala Val Val Asn Phe Leu Ser Arg Lys Ser Lys Leu 
        355                 360                 


<210>  3377
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECSCR__Homo_sapiens__NP_001071161

<400>  3377

Met Gly Thr Ala Gly Ala Met Gln Leu Cys Trp Val Ile Leu Gly Phe 
1               5                   10                  15      


Leu Leu Phe Arg Gly His Asn Ser Gln Pro Thr Met Thr Gln Thr Ser 
            20                  25                  30          


Ser Ser Gln Gly Gly Leu Gly Gly Leu Ser Leu Thr Thr Glu Pro Val 
        35                  40                  45              


Ser Ser Asn Pro Gly Tyr Ile Pro Ser Ser Glu Ala Asn Arg Pro Ser 
    50                  55                  60                  


His Leu Ser Ser Thr Gly Thr Pro Gly Ala Gly Val Pro Ser Ser Gly 
65                  70                  75                  80  


Arg Asp Gly Gly Thr Ser Arg Asp Thr Phe Gln Thr Val Pro Pro Asn 
                85                  90                  95      


Ser Thr Thr Met Ser Leu Ser Met Arg Glu Asp Ala Thr Ile Leu Pro 
            100                 105                 110         


Ser Pro Thr Ser Glu Thr Val Leu Thr Val Ala Ala Phe Gly Val Ile 
        115                 120                 125             


Ser Phe Ile Val Ile Leu Val Val Val Val Ile Ile Leu Val Gly Val 
    130                 135                 140                 


Val Ser Leu Arg Phe Lys Cys Arg Lys Ser Lys Glu Ser Glu Asp Pro 
145                 150                 155                 160 


Gln Lys Pro Gly Ser Ser Gly Leu Ser Glu Ser Cys Ser Thr Ala Asn 
                165                 170                 175     


Gly Glu Lys Asp Ser Ile Thr Leu Ile Ser Met Lys Asn Ile Asn Met 
            180                 185                 190         


Asn Asn Gly Lys Gln Ser Leu Ser Ala Glu Lys Val Leu 
        195                 200                 205 


<210>  3378
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECSIT__Homo_sapiens__NP_001135936

<400>  3378

Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala 
1               5                   10                  15      


Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln 
            20                  25                  30          


Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His 
        35                  40                  45              


Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg 
    50                  55                  60                  


Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro 
65                  70                  75                  80  


Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe 
                85                  90                  95      


Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu 
            100                 105                 110         


Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val 
        115                 120                 125             


Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg 
    130                 135                 140                 


Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys 
145                 150                 155                 160 


Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn 
                165                 170                 175     


Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr 
            180                 185                 190         


Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met 
        195                 200                 205             


Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val 
    210                 215                 220                 


Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala 
225                 230                 235                 240 


Arg Val Thr Ile Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala 
                245                 250                 255     


Ala Asp Pro Pro Gln Pro His Ile Val Gly Ser Gly Arg Asp Ala Gly 
            260                 265                 270         


Gly Val Glu Pro Leu Leu Pro Asp Ala Ala Gly Pro Gly Val Cys Glu 
        275                 280                 285             


Glu Trp Leu Gly Gln Leu Arg Val 
    290                 295     


<210>  3379
<211>  914
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECT2__Homo_sapiens__NP_001245244

<400>  3379

Met Ala Glu Asn Ser Val Leu Thr Ser Thr Thr Gly Arg Thr Ser Leu 
1               5                   10                  15      


Ala Asp Ser Ser Ile Phe Asp Ser Lys Val Thr Glu Ile Ser Lys Glu 
            20                  25                  30          


Asn Leu Leu Ile Gly Ser Thr Ser Tyr Val Glu Glu Glu Met Pro Gln 
        35                  40                  45              


Ile Glu Thr Arg Val Ile Leu Val Gln Glu Ala Gly Lys Gln Glu Glu 
    50                  55                  60                  


Leu Ile Lys Ala Leu Lys Thr Ile Lys Ile Met Glu Val Pro Val Ile 
65                  70                  75                  80  


Lys Ile Lys Glu Ser Cys Pro Gly Lys Ser Asp Glu Lys Leu Ile Lys 
                85                  90                  95      


Ser Val Ile Asn Met Asp Ile Lys Val Gly Phe Val Lys Met Glu Ser 
            100                 105                 110         


Val Glu Glu Phe Glu Gly Leu Asp Ser Pro Glu Phe Glu Asn Val Phe 
        115                 120                 125             


Val Val Thr Asp Phe Gln Asp Ser Val Phe Asn Asp Leu Tyr Lys Ala 
    130                 135                 140                 


Asp Cys Arg Val Ile Gly Pro Pro Val Val Leu Asn Cys Ser Gln Lys 
145                 150                 155                 160 


Gly Glu Pro Leu Pro Phe Ser Cys Arg Pro Leu Tyr Cys Thr Ser Met 
                165                 170                 175     


Met Asn Leu Val Leu Cys Phe Thr Gly Phe Arg Lys Lys Glu Glu Leu 
            180                 185                 190         


Val Arg Leu Val Thr Leu Val His His Met Gly Gly Val Ile Arg Lys 
        195                 200                 205             


Asp Phe Asn Ser Lys Val Thr His Leu Val Ala Asn Cys Thr Gln Gly 
    210                 215                 220                 


Glu Lys Phe Arg Val Ala Val Ser Leu Gly Thr Pro Ile Met Lys Pro 
225                 230                 235                 240 


Glu Trp Ile Tyr Lys Ala Trp Glu Arg Arg Asn Glu Gln Asp Phe Tyr 
                245                 250                 255     


Ala Ala Val Asp Asp Phe Arg Asn Glu Phe Lys Val Pro Pro Phe Gln 
            260                 265                 270         


Asp Cys Ile Leu Ser Phe Leu Gly Phe Ser Asp Glu Glu Lys Thr Asn 
        275                 280                 285             


Met Glu Glu Met Thr Glu Met Gln Gly Gly Lys Tyr Leu Pro Leu Gly 
    290                 295                 300                 


Asp Glu Arg Cys Thr His Leu Val Val Glu Glu Asn Ile Val Lys Asp 
305                 310                 315                 320 


Leu Pro Phe Glu Pro Ser Lys Lys Leu Tyr Val Val Lys Gln Glu Trp 
                325                 330                 335     


Phe Trp Gly Ser Ile Gln Met Asp Ala Arg Ala Gly Glu Thr Met Tyr 
            340                 345                 350         


Leu Tyr Glu Lys Ala Asn Thr Pro Glu Leu Lys Lys Ser Val Ser Met 
        355                 360                 365             


Leu Ser Leu Asn Thr Pro Asn Ser Asn Arg Lys Arg Arg Arg Leu Lys 
    370                 375                 380                 


Glu Thr Leu Ala Gln Leu Ser Arg Glu Thr Asp Val Ser Pro Phe Pro 
385                 390                 395                 400 


Pro Arg Lys Arg Pro Ser Ala Glu His Ser Leu Ser Ile Gly Ser Leu 
                405                 410                 415     


Leu Asp Ile Ser Asn Thr Pro Glu Ser Ser Ile Asn Tyr Gly Asp Thr 
            420                 425                 430         


Pro Lys Ser Cys Thr Lys Ser Ser Lys Ser Ser Thr Pro Val Pro Ser 
        435                 440                 445             


Lys Gln Ser Ala Arg Trp Gln Val Ala Lys Glu Leu Tyr Gln Thr Glu 
    450                 455                 460                 


Ser Asn Tyr Val Asn Ile Leu Ala Thr Ile Ile Gln Leu Phe Gln Val 
465                 470                 475                 480 


Pro Leu Glu Glu Glu Gly Gln Arg Gly Gly Pro Ile Leu Ala Pro Glu 
                485                 490                 495     


Glu Ile Lys Thr Ile Phe Gly Ser Ile Pro Asp Ile Phe Asp Val His 
            500                 505                 510         


Thr Lys Ile Lys Asp Asp Leu Glu Asp Leu Ile Val Asn Trp Asp Glu 
        515                 520                 525             


Ser Lys Ser Ile Gly Asp Ile Phe Leu Lys Tyr Ser Lys Asp Leu Val 
    530                 535                 540                 


Lys Thr Tyr Pro Pro Phe Val Asn Phe Phe Glu Met Ser Lys Glu Thr 
545                 550                 555                 560 


Ile Ile Lys Cys Glu Lys Gln Lys Pro Arg Phe His Ala Phe Leu Lys 
                565                 570                 575     


Ile Asn Gln Ala Lys Pro Glu Cys Gly Arg Gln Ser Leu Val Glu Leu 
            580                 585                 590         


Leu Ile Arg Pro Val Gln Arg Leu Pro Ser Val Ala Leu Leu Leu Asn 
        595                 600                 605             


Asp Leu Lys Lys His Thr Ala Asp Glu Asn Pro Asp Lys Ser Thr Leu 
    610                 615                 620                 


Glu Lys Ala Ile Gly Ser Leu Lys Glu Val Met Thr His Ile Asn Glu 
625                 630                 635                 640 


Asp Lys Arg Lys Thr Glu Ala Gln Lys Gln Ile Phe Asp Val Val Tyr 
                645                 650                 655     


Glu Val Asp Gly Cys Pro Ala Asn Leu Leu Ser Ser His Arg Ser Leu 
            660                 665                 670         


Val Gln Arg Val Glu Thr Ile Ser Leu Gly Glu His Pro Cys Asp Arg 
        675                 680                 685             


Gly Glu Gln Val Thr Leu Phe Leu Phe Asn Asp Cys Leu Glu Ile Ala 
    690                 695                 700                 


Arg Lys Arg His Lys Val Ile Gly Thr Phe Arg Ser Pro His Gly Gln 
705                 710                 715                 720 


Thr Arg Pro Pro Ala Ser Leu Lys His Ile His Leu Met Pro Leu Ser 
                725                 730                 735     


Gln Ile Lys Lys Val Leu Asp Ile Arg Glu Thr Glu Asp Cys His Asn 
            740                 745                 750         


Ala Phe Ala Leu Leu Val Arg Pro Pro Thr Glu Gln Ala Asn Val Leu 
        755                 760                 765             


Leu Ser Phe Gln Met Thr Ser Asp Glu Leu Pro Lys Glu Asn Trp Leu 
    770                 775                 780                 


Lys Met Leu Cys Arg His Val Ala Asn Thr Ile Cys Lys Ala Asp Ala 
785                 790                 795                 800 


Glu Asn Leu Ile Tyr Thr Ala Asp Pro Glu Ser Phe Glu Val Asn Thr 
                805                 810                 815     


Lys Asp Met Asp Ser Thr Leu Ser Arg Ala Ser Arg Ala Ile Lys Lys 
            820                 825                 830         


Thr Ser Lys Lys Val Thr Arg Ala Phe Ser Phe Ser Lys Thr Pro Lys 
        835                 840                 845             


Arg Ala Leu Arg Arg Ala Leu Met Thr Ser His Gly Ser Val Glu Gly 
    850                 855                 860                 


Arg Ser Pro Ser Ser Asn Asp Lys His Val Met Ser Arg Leu Ser Ser 
865                 870                 875                 880 


Thr Ser Ser Leu Ala Gly Ile Pro Ser Pro Ser Leu Val Ser Leu Pro 
                885                 890                 895     


Ser Phe Phe Glu Arg Arg Ser His Thr Leu Ser Arg Ser Thr Thr His 
            900                 905                 910         


Leu Ile 
        


<210>  3380
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDA2R__Homo_sapiens__NP_001186616

<400>  3380

Met Asp Cys Gln Glu Asn Glu Tyr Trp Asp Gln Trp Gly Arg Cys Val 
1               5                   10                  15      


Thr Cys Gln Arg Cys Gly Pro Gly Gln Glu Leu Ser Lys Asp Cys Gly 
            20                  25                  30          


Tyr Gly Glu Gly Gly Asp Ala Tyr Cys Thr Ala Cys Pro Pro Arg Arg 
        35                  40                  45              


Tyr Lys Ser Ser Trp Gly His His Arg Cys Gln Ser Cys Ile Thr Cys 
    50                  55                  60                  


Ala Val Ile Asn Arg Val Gln Lys Val Asn Cys Thr Ala Thr Ser Asn 
65                  70                  75                  80  


Ala Val Cys Gly Asp Cys Leu Pro Arg Phe Tyr Arg Lys Thr Arg Ile 
                85                  90                  95      


Gly Gly Leu Gln Asp Gln Glu Cys Ile Pro Cys Thr Lys Gln Thr Pro 
            100                 105                 110         


Thr Ser Glu Val Gln Cys Ala Phe Gln Leu Ser Leu Val Glu Ala Asp 
        115                 120                 125             


Ala Pro Thr Val Pro Pro Gln Glu Ala Thr Leu Val Ala Leu Val Ser 
    130                 135                 140                 


Ser Leu Leu Val Val Phe Thr Leu Ala Phe Leu Gly Leu Phe Phe Leu 
145                 150                 155                 160 


Tyr Cys Lys Gln Phe Phe Asn Arg His Cys Gln Arg Gly Gly Leu Leu 
                165                 170                 175     


Gln Phe Glu Ala Asp Lys Thr Ala Lys Glu Glu Ser Leu Phe Pro Val 
            180                 185                 190         


Pro Pro Ser Lys Glu Thr Ser Ala Glu Ser Gln Val Ser Glu Asn Ile 
        195                 200                 205             


Phe Gln Thr Gln Pro Leu Asn Pro Ile Leu Glu Asp Asp Cys Ser Ser 
    210                 215                 220                 


Thr Ser Gly Phe Pro Thr Gln Glu Ser Phe Thr Met Ala Ser Cys Thr 
225                 230                 235                 240 


Ser Glu Ser His Ser His Trp Val His Ser Pro Ile Glu Cys Thr Glu 
                245                 250                 255     


Leu Asp Leu Gln Lys Phe Ser Ser Ser Ala Ser Tyr Thr Gly Ala Glu 
            260                 265                 270         


Thr Leu Gly Gly Asn Thr Val Glu Ser Thr Gly Asp Arg Leu Glu Leu 
        275                 280                 285             


Asn Val Pro Phe Glu Val Pro Ser Pro 
    290                 295         


<210>  3381
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDA__Homo_sapiens__NP_001005609

<400>  3381

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 
    130                 135                 140                 


Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 
145                 150                 155                 160 


Lys Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 
                165                 170                 175     


Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly 
            180                 185                 190         


Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 
        195                 200                 205             


Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    210                 215                 220                 


Pro Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln 
                245                 250                 255     


Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn 
            260                 265                 270         


Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro 
        275                 280                 285             


Arg Ser Gly Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr 
    290                 295                 300                 


Ser Gln Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr Glu Val 
305                 310                 315                 320 


Val Val Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile Glu Thr 
                325                 330                 335     


Gly Lys Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys Leu Leu 
            340                 345                 350         


Lys Ala Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp Ile Ser 
        355                 360                 365             


Ile Asn Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg Leu Gly 
    370                 375                 380                 


Glu Ala Pro Ala Ser 
385                 


<210>  3382
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDARADD__Homo_sapiens__NP_542776

<400>  3382

Met Ala Ser Pro Asp Asp Pro Leu Arg Ala Asp His Met Val Lys Glu 
1               5                   10                  15      


Pro Val Glu Asp Thr Asp Pro Ser Thr Leu Ser Phe Asn Met Ser Asp 
            20                  25                  30          


Lys Tyr Pro Ile Gln Asp Thr Glu Leu Pro Lys Ala Glu Glu Cys Asp 
        35                  40                  45              


Thr Ile Thr Leu Asn Cys Pro Arg Asn Ser Asp Met Lys Asn Gln Gly 
    50                  55                  60                  


Glu Glu Asn Gly Phe Pro Asp Ser Thr Gly Asp Pro Leu Pro Glu Ile 
65                  70                  75                  80  


Ser Lys Asp Asn Ser Cys Lys Glu Asn Cys Thr Cys Ser Ser Cys Leu 
                85                  90                  95      


Leu Arg Ala Pro Thr Ile Ser Asp Leu Leu Asn Asp Gln Asp Leu Leu 
            100                 105                 110         


Asp Val Ile Arg Ile Lys Leu Asp Pro Cys His Pro Thr Val Lys Asn 
        115                 120                 125             


Trp Arg Asn Phe Ala Ser Lys Trp Gly Met Ser Tyr Asp Glu Leu Cys 
    130                 135                 140                 


Phe Leu Glu Gln Arg Pro Gln Ser Pro Thr Leu Glu Phe Leu Leu Arg 
145                 150                 155                 160 


Asn Ser Gln Arg Thr Val Gly Gln Leu Met Glu Leu Cys Arg Leu Tyr 
                165                 170                 175     


His Arg Ala Asp Val Glu Lys Val Leu Arg Arg Trp Val Asp Glu Glu 
            180                 185                 190         


Trp Pro Lys Arg Glu Arg Gly Asp Pro Ser Arg His Phe 
        195                 200                 205 


<210>  3383
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDAR__Homo_sapiens__NP_071731

<400>  3383

Met Ala His Val Gly Asp Cys Thr Gln Thr Pro Trp Leu Pro Val Leu 
1               5                   10                  15      


Val Val Ser Leu Met Cys Ser Ala Arg Ala Glu Tyr Ser Asn Cys Gly 
            20                  25                  30          


Glu Asn Glu Tyr Tyr Asn Gln Thr Thr Gly Leu Cys Gln Glu Cys Pro 
        35                  40                  45              


Pro Cys Gly Pro Gly Glu Glu Pro Tyr Leu Ser Cys Gly Tyr Gly Thr 
    50                  55                  60                  


Lys Asp Glu Asp Tyr Gly Cys Val Pro Cys Pro Ala Glu Lys Phe Ser 
65                  70                  75                  80  


Lys Gly Gly Tyr Gln Ile Cys Arg Arg His Lys Asp Cys Glu Gly Phe 
                85                  90                  95      


Phe Arg Ala Thr Val Leu Thr Pro Gly Asp Met Glu Asn Asp Ala Glu 
            100                 105                 110         


Cys Gly Pro Cys Leu Pro Gly Tyr Tyr Met Leu Glu Asn Arg Pro Arg 
        115                 120                 125             


Asn Ile Tyr Gly Met Val Cys Tyr Ser Cys Leu Leu Ala Pro Pro Asn 
    130                 135                 140                 


Thr Lys Glu Cys Val Gly Ala Thr Ser Gly Ala Ser Ala Asn Phe Pro 
145                 150                 155                 160 


Gly Thr Ser Gly Ser Ser Thr Leu Ser Pro Phe Gln His Ala His Lys 
                165                 170                 175     


Glu Leu Ser Gly Gln Gly His Leu Ala Thr Ala Leu Ile Ile Ala Met 
            180                 185                 190         


Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val Leu Ile Ile Met Phe 
        195                 200                 205             


Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
    210                 215                 220                 


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
225                 230                 235                 240 


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
                245                 250                 255     


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
            260                 265                 270         


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
        275                 280                 285             


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
    290                 295                 300                 


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
305                 310                 315                 320 


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
                325                 330                 335     


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
            340                 345                 350         


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
        355                 360                 365             


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
    370                 375                 380                 


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
385                 390                 395                 400 


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
                405                 410                 415     


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
            420                 425                 430         


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
        435                 440                 445             


<210>  3384
<211>  1401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDC4__Homo_sapiens__NP_055144

<400>  3384

Met Ala Ser Cys Ala Ser Ile Asp Ile Glu Asp Ala Thr Gln His Leu 
1               5                   10                  15      


Arg Asp Ile Leu Lys Leu Asp Arg Pro Ala Gly Gly Pro Ser Ala Glu 
            20                  25                  30          


Ser Pro Arg Pro Ser Ser Ala Tyr Asn Gly Asp Leu Asn Gly Leu Leu 
        35                  40                  45              


Val Pro Asp Pro Leu Cys Ser Gly Asp Ser Thr Ser Ala Asn Lys Thr 
    50                  55                  60                  


Gly Leu Arg Thr Met Pro Pro Ile Asn Leu Gln Glu Lys Gln Val Ile 
65                  70                  75                  80  


Cys Leu Ser Gly Asp Asp Ser Ser Thr Cys Ile Gly Ile Leu Ala Lys 
                85                  90                  95      


Glu Val Glu Ile Val Ala Ser Ser Asp Ser Ser Ile Ser Ser Lys Ala 
            100                 105                 110         


Arg Gly Ser Asn Lys Val Lys Ile Gln Pro Val Ala Lys Tyr Asp Trp 
        115                 120                 125             


Glu Gln Lys Tyr Tyr Tyr Gly Asn Leu Ile Ala Val Ser Asn Ser Phe 
    130                 135                 140                 


Leu Ala Tyr Ala Ile Arg Ala Ala Asn Asn Gly Ser Ala Met Val Arg 
145                 150                 155                 160 


Val Ile Ser Val Ser Thr Ser Glu Arg Thr Leu Leu Lys Gly Phe Thr 
                165                 170                 175     


Gly Ser Val Ala Asp Leu Ala Phe Ala His Leu Asn Ser Pro Gln Leu 
            180                 185                 190         


Ala Cys Leu Asp Glu Ala Gly Asn Leu Phe Val Trp Arg Leu Ala Leu 
        195                 200                 205             


Val Asn Gly Lys Ile Gln Glu Glu Ile Leu Val His Ile Arg Gln Pro 
    210                 215                 220                 


Glu Gly Thr Pro Leu Asn His Phe Arg Arg Ile Ile Trp Cys Pro Phe 
225                 230                 235                 240 


Ile Pro Glu Glu Ser Glu Asp Cys Cys Glu Glu Ser Ser Pro Thr Val 
                245                 250                 255     


Ala Leu Leu His Glu Asp Arg Ala Glu Val Trp Asp Leu Asp Met Leu 
            260                 265                 270         


Arg Ser Ser His Ser Thr Trp Pro Val Asp Val Ser Gln Ile Lys Gln 
        275                 280                 285             


Gly Phe Ile Val Val Lys Gly His Ser Thr Cys Leu Ser Glu Gly Ala 
    290                 295                 300                 


Leu Ser Pro Asp Gly Thr Val Leu Ala Thr Ala Ser His Asp Gly Tyr 
305                 310                 315                 320 


Val Lys Phe Trp Gln Ile Tyr Ile Glu Gly Gln Asp Glu Pro Arg Cys 
                325                 330                 335     


Leu His Glu Trp Lys Pro His Asp Gly Arg Pro Leu Ser Cys Leu Leu 
            340                 345                 350         


Phe Cys Asp Asn His Lys Lys Gln Asp Pro Asp Val Pro Phe Trp Arg 
        355                 360                 365             


Phe Leu Ile Thr Gly Ala Asp Gln Asn Arg Glu Leu Lys Met Trp Cys 
    370                 375                 380                 


Thr Val Ser Trp Thr Cys Leu Gln Thr Ile Arg Phe Ser Pro Asp Ile 
385                 390                 395                 400 


Phe Ser Ser Val Ser Val Pro Pro Ser Leu Lys Val Cys Leu Asp Leu 
                405                 410                 415     


Ser Ala Glu Tyr Leu Ile Leu Ser Asp Val Gln Arg Lys Val Leu Tyr 
            420                 425                 430         


Val Met Glu Leu Leu Gln Asn Gln Glu Glu Gly His Ala Cys Phe Ser 
        435                 440                 445             


Ser Ile Ser Glu Phe Leu Leu Thr His Pro Val Leu Ser Phe Gly Ile 
    450                 455                 460                 


Gln Val Val Ser Arg Cys Arg Leu Arg His Thr Glu Val Leu Pro Ala 
465                 470                 475                 480 


Glu Glu Glu Asn Asp Ser Leu Gly Ala Asp Gly Thr His Gly Ala Gly 
                485                 490                 495     


Ala Met Glu Ser Ala Ala Gly Val Leu Ile Lys Leu Phe Cys Val His 
            500                 505                 510         


Thr Lys Ala Leu Gln Asp Val Gln Ile Arg Phe Gln Pro Gln Leu Asn 
        515                 520                 525             


Pro Asp Val Val Ala Pro Leu Pro Thr His Thr Ala His Glu Asp Phe 
    530                 535                 540                 


Thr Phe Gly Glu Ser Arg Pro Glu Leu Gly Ser Glu Gly Leu Gly Ser 
545                 550                 555                 560 


Ala Ala His Gly Ser Gln Pro Asp Leu Arg Arg Ile Val Glu Leu Pro 
                565                 570                 575     


Ala Pro Ala Asp Phe Leu Ser Leu Ser Ser Glu Thr Lys Pro Lys Leu 
            580                 585                 590         


Met Thr Pro Asp Ala Phe Met Thr Pro Ser Ala Ser Leu Gln Gln Ile 
        595                 600                 605             


Thr Ala Ser Pro Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
    610                 615                 620                 


Ser Ser Ser Ser Ser Leu Thr Ala Val Ser Ala Met Ser Ser Thr Ser 
625                 630                 635                 640 


Ala Val Asp Pro Ser Leu Thr Arg Pro Pro Glu Glu Leu Thr Leu Ser 
                645                 650                 655     


Pro Lys Leu Gln Leu Asp Gly Ser Leu Thr Met Ser Ser Ser Gly Ser 
            660                 665                 670         


Leu Gln Ala Ser Pro Arg Gly Leu Leu Pro Gly Leu Leu Pro Ala Pro 
        675                 680                 685             


Ala Asp Lys Leu Thr Pro Lys Gly Pro Gly Gln Val Pro Thr Ala Thr 
    690                 695                 700                 


Ser Ala Leu Ser Leu Glu Leu Gln Glu Val Glu Pro Leu Gly Leu Pro 
705                 710                 715                 720 


Gln Ala Ser Pro Ser Arg Thr Arg Ser Pro Asp Val Ile Ser Ser Ala 
                725                 730                 735     


Ser Thr Ala Leu Ser Gln Asp Ile Pro Glu Ile Ala Ser Glu Ala Leu 
            740                 745                 750         


Ser Arg Gly Phe Gly Ser Ser Ala Pro Glu Gly Leu Glu Pro Asp Ser 
        755                 760                 765             


Met Ala Ser Ala Ala Ser Ala Leu His Leu Leu Ser Pro Arg Pro Arg 
    770                 775                 780                 


Pro Gly Pro Glu Leu Gly Pro Gln Leu Gly Leu Asp Gly Gly Pro Gly 
785                 790                 795                 800 


Asp Gly Asp Arg His Asn Thr Pro Ser Leu Leu Glu Ala Ala Leu Thr 
                805                 810                 815     


Gln Glu Ala Ser Thr Pro Asp Ser Gln Val Trp Pro Thr Ala Pro Asp 
            820                 825                 830         


Ile Thr Arg Glu Thr Cys Ser Thr Leu Ala Glu Ser Pro Arg Asn Gly 
        835                 840                 845             


Leu Gln Glu Lys His Lys Ser Leu Ala Phe His Arg Pro Pro Tyr His 
    850                 855                 860                 


Leu Leu Gln Gln Arg Asp Ser Gln Asp Ala Ser Ala Glu Gln Ser Asp 
865                 870                 875                 880 


His Asp Asp Glu Val Ala Ser Leu Ala Ser Ala Ser Gly Gly Phe Gly 
                885                 890                 895     


Thr Lys Val Pro Ala Pro Arg Leu Pro Ala Lys Asp Trp Lys Thr Lys 
            900                 905                 910         


Gly Ser Pro Arg Thr Ser Pro Lys Leu Lys Arg Lys Ser Lys Lys Asp 
        915                 920                 925             


Asp Gly Asp Ala Ala Met Gly Ser Arg Leu Thr Glu His Gln Val Ala 
    930                 935                 940                 


Glu Pro Pro Glu Asp Trp Pro Ala Leu Ile Trp Gln Gln Gln Arg Glu 
945                 950                 955                 960 


Leu Ala Glu Leu Arg His Ser Gln Glu Glu Leu Leu Gln Arg Leu Cys 
                965                 970                 975     


Thr Gln Leu Glu Gly Leu Gln Ser Thr Val Thr Gly His Val Glu Arg 
            980                 985                 990         


Ala Leu Glu Thr Arg His Glu Gln  Glu Gln Arg Arg Leu  Glu Arg Ala 
        995                 1000                 1005             


Leu Ala  Glu Gly Gln Gln Arg  Gly Gly Gln Leu Gln  Glu Gln Leu 
    1010                 1015                 1020             


Thr Gln  Gln Leu Ser Gln Ala  Leu Ser Ser Ala Val  Ala Gly Arg 
    1025                 1030                 1035             


Leu Glu  Arg Ser Ile Arg Asp  Glu Ile Lys Lys Thr  Val Pro Pro 
    1040                 1045                 1050             


Cys Val  Ser Arg Ser Leu Glu  Pro Met Ala Gly Gln  Leu Ser Asn 
    1055                 1060                 1065             


Ser Val  Ala Thr Lys Leu Thr  Ala Val Glu Gly Ser  Met Lys Glu 
    1070                 1075                 1080             


Asn Ile  Ser Lys Leu Leu Lys  Ser Lys Asn Leu Thr  Asp Ala Ile 
    1085                 1090                 1095             


Ala Arg  Ala Ala Ala Asp Thr  Leu Gln Gly Pro Met  Gln Ala Ala 
    1100                 1105                 1110             


Tyr Arg  Glu Ala Phe Gln Ser  Val Val Leu Pro Ala  Phe Glu Lys 
    1115                 1120                 1125             


Ser Cys  Gln Ala Met Phe Gln  Gln Ile Asn Asp Ser  Phe Arg Leu 
    1130                 1135                 1140             


Gly Thr  Gln Glu Tyr Leu Gln  Gln Leu Glu Ser His  Met Lys Ser 
    1145                 1150                 1155             


Arg Lys  Ala Arg Glu Gln Glu  Ala Arg Glu Pro Val  Leu Ala Gln 
    1160                 1165                 1170             


Leu Arg  Gly Leu Val Ser Thr  Leu Gln Ser Ala Thr  Glu Gln Met 
    1175                 1180                 1185             


Ala Ala  Thr Val Ala Gly Ser  Val Arg Ala Glu Val  Gln His Gln 
    1190                 1195                 1200             


Leu His  Val Ala Val Gly Ser  Leu Gln Glu Ser Ile  Leu Ala Gln 
    1205                 1210                 1215             


Val Gln  Arg Ile Val Lys Gly  Glu Val Ser Val Ala  Leu Lys Glu 
    1220                 1225                 1230             


Gln Gln  Ala Ala Val Thr Ser  Ser Ile Met Gln Ala  Met Arg Ser 
    1235                 1240                 1245             


Ala Ala  Gly Thr Pro Val Pro  Ser Ala His Leu Asp  Cys Gln Ala 
    1250                 1255                 1260             


Gln Gln  Ala His Ile Leu Gln  Leu Leu Gln Gln Gly  His Leu Asn 
    1265                 1270                 1275             


Gln Ala  Phe Gln Gln Ala Leu  Thr Ala Ala Asp Leu  Asn Leu Val 
    1280                 1285                 1290             


Leu Tyr  Val Cys Glu Thr Val  Asp Pro Ala Gln Val  Phe Gly Gln 
    1295                 1300                 1305             


Pro Pro  Cys Pro Leu Ser Gln  Pro Val Leu Leu Ser  Leu Ile Gln 
    1310                 1315                 1320             


Gln Leu  Ala Ser Asp Leu Gly  Thr Arg Thr Asp Leu  Lys Leu Ser 
    1325                 1330                 1335             


Tyr Leu  Glu Glu Ala Val Met  His Leu Asp His Ser  Asp Pro Ile 
    1340                 1345                 1350             


Thr Arg  Asp His Met Gly Ser  Val Met Ala Gln Val  Arg Gln Lys 
    1355                 1360                 1365             


Leu Phe  Gln Phe Leu Gln Ala  Glu Pro His Asn Ser  Leu Gly Lys 
    1370                 1375                 1380             


Ala Ala  Arg Arg Leu Ser Leu  Met Leu His Gly Leu  Val Thr Pro 
    1385                 1390                 1395             


Ser Leu  Pro 
    1400     


<210>  3385
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDEM1__Homo_sapiens__NP_055489

<400>  3385

Met Gln Trp Arg Ala Leu Val Leu Gly Leu Val Leu Leu Arg Leu Gly 
1               5                   10                  15      


Leu His Gly Val Leu Trp Leu Val Phe Gly Leu Gly Pro Ser Met Gly 
            20                  25                  30          


Phe Tyr Gln Arg Phe Pro Leu Ser Phe Gly Phe Gln Arg Leu Arg Ser 
        35                  40                  45              


Pro Asp Gly Pro Ala Ser Pro Thr Ser Gly Pro Val Gly Arg Pro Gly 
    50                  55                  60                  


Gly Val Ser Gly Pro Ser Trp Leu Gln Pro Pro Gly Thr Gly Ala Ala 
65                  70                  75                  80  


Gln Ser Pro Arg Lys Ala Pro Arg Arg Pro Gly Pro Gly Met Cys Gly 
                85                  90                  95      


Pro Ala Asn Trp Gly Tyr Val Leu Gly Gly Arg Gly Arg Gly Pro Asp 
            100                 105                 110         


Glu Tyr Glu Lys Arg Tyr Ser Gly Ala Phe Pro Pro Gln Leu Arg Ala 
        115                 120                 125             


Gln Met Arg Asp Leu Ala Arg Gly Met Phe Val Phe Gly Tyr Asp Asn 
    130                 135                 140                 


Tyr Met Ala His Ala Phe Pro Gln Asp Glu Leu Asn Pro Ile His Cys 
145                 150                 155                 160 


Arg Gly Arg Gly Pro Asp Arg Gly Asp Pro Ser Asn Leu Asn Ile Asn 
                165                 170                 175     


Asp Val Leu Gly Asn Tyr Ser Leu Thr Leu Val Asp Ala Leu Asp Thr 
            180                 185                 190         


Leu Ala Ile Met Gly Asn Ser Ser Glu Phe Gln Lys Ala Val Lys Leu 
        195                 200                 205             


Val Ile Asn Thr Val Ser Phe Asp Lys Asp Ser Thr Val Gln Val Phe 
    210                 215                 220                 


Glu Ala Thr Ile Arg Val Leu Gly Ser Leu Leu Ser Ala His Arg Ile 
225                 230                 235                 240 


Ile Thr Asp Ser Lys Gln Pro Phe Gly Asp Met Thr Ile Lys Asp Tyr 
                245                 250                 255     


Asp Asn Glu Leu Leu Tyr Met Ala His Asp Leu Ala Val Arg Leu Leu 
            260                 265                 270         


Pro Ala Phe Glu Asn Thr Lys Thr Gly Ile Pro Tyr Pro Arg Val Asn 
        275                 280                 285             


Leu Lys Thr Gly Val Pro Pro Asp Thr Asn Asn Glu Thr Cys Thr Ala 
    290                 295                 300                 


Gly Ala Gly Ser Leu Leu Val Glu Phe Gly Ile Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Gly Asp Ser Thr Phe Glu Trp Val Ala Arg Arg Ala Val Lys Ala Leu 
                325                 330                 335     


Trp Asn Leu Arg Ser Asn Asp Thr Gly Leu Leu Gly Asn Val Val Asn 
            340                 345                 350         


Ile Gln Thr Gly His Trp Val Gly Lys Gln Ser Gly Leu Gly Ala Gly 
        355                 360                 365             


Leu Asp Ser Phe Tyr Glu Tyr Leu Leu Lys Ser Tyr Ile Leu Phe Gly 
    370                 375                 380                 


Glu Lys Glu Asp Leu Glu Met Phe Asn Ala Ala Tyr Gln Ser Ile Gln 
385                 390                 395                 400 


Asn Tyr Leu Arg Arg Gly Arg Glu Ala Cys Asn Glu Gly Glu Gly Asp 
                405                 410                 415     


Pro Pro Leu Tyr Val Asn Val Asn Met Phe Ser Gly Gln Leu Met Asn 
            420                 425                 430         


Thr Trp Ile Asp Ser Leu Gln Ala Phe Phe Pro Gly Leu Gln Val Leu 
        435                 440                 445             


Ile Gly Asp Val Glu Asp Ala Ile Cys Leu His Ala Phe Tyr Tyr Ala 
    450                 455                 460                 


Ile Trp Lys Arg Tyr Gly Ala Leu Pro Glu Arg Tyr Asn Trp Gln Leu 
465                 470                 475                 480 


Gln Ala Pro Asp Val Leu Phe Tyr Pro Leu Arg Pro Glu Leu Val Glu 
                485                 490                 495     


Ser Thr Tyr Leu Leu Tyr Gln Ala Thr Lys Asn Pro Phe Tyr Leu His 
            500                 505                 510         


Val Gly Met Asp Ile Leu Gln Ser Leu Glu Lys Tyr Thr Lys Val Lys 
        515                 520                 525             


Cys Gly Tyr Ala Thr Leu His His Val Ile Asp Lys Ser Thr Glu Asp 
    530                 535                 540                 


Arg Met Glu Ser Phe Phe Leu Ser Glu Thr Cys Lys Tyr Leu Tyr Leu 
545                 550                 555                 560 


Leu Phe Asp Glu Asp Asn Pro Val His Lys Ser Gly Thr Arg Tyr Met 
                565                 570                 575     


Phe Thr Thr Glu Gly His Ile Val Ser Val Asp Glu His Leu Arg Glu 
            580                 585                 590         


Leu Pro Trp Lys Glu Phe Phe Ser Glu Glu Gly Gly Gln Asp Gln Gly 
        595                 600                 605             


Gly Lys Ser Val His Arg Pro Lys Pro His Glu Leu Lys Val Ile Asn 
    610                 615                 620                 


Ser Ser Ser Asn Cys Asn Arg Val Pro Asp Glu Arg Arg Tyr Ser Leu 
625                 630                 635                 640 


Pro Leu Lys Ser Ile Tyr Met Arg Gln Ile Asp Gln Met Val Gly Leu 
                645                 650                 655     


Ile 
    


<210>  3386
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDIL3__Homo_sapiens__NP_001265571

<400>  3386

Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly 
1               5                   10                  15      


Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu 
            20                  25                  30          


Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys 
        35                  40                  45              


Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu 
    50                  55                  60                  


Val Gly Pro Cys Thr Pro Asn Pro Cys His Asn Gly Gly Thr Cys Glu 
65                  70                  75                  80  


Ile Ser Glu Ala Tyr Arg Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys 
                85                  90                  95      


Cys Pro Arg Gly Phe Asn Gly Ile His Cys Gln His Asn Ile Asn Glu 
            100                 105                 110         


Cys Glu Val Glu Pro Cys Lys Asn Gly Gly Ile Cys Thr Asp Leu Val 
        115                 120                 125             


Ala Asn Tyr Ser Cys Glu Cys Pro Gly Glu Phe Met Gly Arg Asn Cys 
    130                 135                 140                 


Gln Tyr Lys Cys Ser Gly Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser 
145                 150                 155                 160 


Asn Gln Gln Ile Thr Ala Ser Ser Thr His Arg Ala Leu Phe Gly Leu 
                165                 170                 175     


Gln Lys Trp Tyr Pro Tyr Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile 
            180                 185                 190         


Asn Ala Trp Thr Ala Ala Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile 
        195                 200                 205             


Asn Leu Gln Arg Lys Met Arg Val Thr Gly Val Ile Thr Gln Gly Ala 
    210                 215                 220                 


Lys Arg Ile Gly Ser Pro Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr 
225                 230                 235                 240 


Ser Asn Asp Gly Lys Thr Trp Ala Met Tyr Lys Val Lys Gly Thr Asn 
                245                 250                 255     


Glu Asp Met Val Phe Arg Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala 
            260                 265                 270         


Asn Ser Phe Thr Pro Pro Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro 
        275                 280                 285             


Gln Val Cys Arg Arg His Cys Thr Leu Arg Met Glu Leu Leu Gly Cys 
    290                 295                 300                 


Glu Leu Ser Gly Cys Ser Glu Pro Leu Gly Met Lys Ser Gly His Ile 
305                 310                 315                 320 


Gln Asp Tyr Gln Ile Thr Ala Ser Ser Ile Phe Arg Thr Leu Asn Met 
                325                 330                 335     


Asp Met Phe Thr Trp Glu Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly 
            340                 345                 350         


Lys Val Asn Ala Trp Thr Ser Gly His Asn Asp Gln Ser Gln Trp Leu 
        355                 360                 365             


Gln Val Asp Leu Leu Val Pro Thr Lys Val Thr Gly Ile Ile Thr Gln 
    370                 375                 380                 


Gly Ala Lys Asp Phe Gly His Val Gln Phe Val Gly Ser Tyr Lys Leu 
385                 390                 395                 400 


Ala Tyr Ser Asn Asp Gly Glu His Trp Thr Val Tyr Gln Asp Glu Lys 
                405                 410                 415     


Gln Arg Lys Asp Lys Val Phe Gln Gly Asn Phe Asp Asn Asp Thr His 
            420                 425                 430         


Arg Lys Asn Val Ile Asp Pro Pro Ile Tyr Ala Arg His Ile Arg Ile 
        435                 440                 445             


Leu Pro Trp Ser Trp Tyr Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu 
    450                 455                 460                 


Gly Cys Thr Glu Glu Glu 
465                 470 


<210>  3387
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDN1__Homo_sapiens__NP_001946

<400>  3387

Met Asp Tyr Leu Leu Met Ile Phe Ser Leu Leu Phe Val Ala Cys Gln 
1               5                   10                  15      


Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly 
            20                  25                  30          


Glu Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn 
                85                  90                  95      


Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala 
            100                 105                 110         


Ser Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu 
        115                 120                 125             


Leu Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys 
    130                 135                 140                 


Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu 
145                 150                 155                 160 


Val Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln 
                165                 170                 175     


Thr Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp 
            180                 185                 190         


Pro Lys Leu Lys Gly Lys Pro Ser Arg Glu Arg Tyr Val Thr His Asn 
        195                 200                 205             


Arg Ala His Trp 
    210         


<210>  3388
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDN3__Homo_sapiens__NP_001289385

<400>  3388

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30          


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60                  


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80  


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140                 


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160 


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175     


Leu Asp Val Ser Arg Leu Lys Ser Arg Thr Asn Lys Ala Ser Arg Leu 
            180                 185                 190         


<210>  3389
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDNRA__Homo_sapiens__NP_001159527

<400>  3389

Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Phe Tyr Gln Asp 
    130                 135                 140                 


Val Lys Asp Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val 
145                 150                 155                 160 


Cys Thr Ala Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg 
                165                 170                 175     


Arg Asn Gly Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg 
            180                 185                 190         


Arg Glu Val Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu 
        195                 200                 205             


Cys Trp Phe Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr 
    210                 215                 220                 


Asn Glu Met Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu 
225                 230                 235                 240 


Met Asp Tyr Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn 
                245                 250                 255     


Pro Ile Ala Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln 
            260                 265                 270         


Ser Cys Leu Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser 
        275                 280                 285             


Val Pro Met Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn 
    290                 295                 300                 


Asn His Asn Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
305                 310                 315             


<210>  3390
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EDNRB__Homo_sapiens__NP_000106

<400>  3390

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  3391
<211>  1411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEA1__Homo_sapiens__NP_003557

<400>  3391

Met Leu Arg Arg Ile Leu Gln Arg Thr Pro Gly Arg Val Gly Ser Gln 
1               5                   10                  15      


Gly Ser Asp Leu Asp Ser Ser Ala Thr Pro Ile Asn Thr Val Asp Val 
            20                  25                  30          


Asn Asn Glu Ser Ser Ser Glu Gly Phe Ile Cys Pro Gln Cys Met Lys 
        35                  40                  45              


Ser Leu Gly Ser Ala Asp Glu Leu Phe Lys His Tyr Glu Ala Val His 
    50                  55                  60                  


Asp Ala Gly Asn Asp Ser Gly His Gly Gly Glu Ser Asn Leu Ala Leu 
65                  70                  75                  80  


Lys Arg Asp Asp Val Thr Leu Leu Arg Gln Glu Val Gln Asp Leu Gln 
                85                  90                  95      


Ala Ser Leu Lys Glu Glu Lys Trp Tyr Ser Glu Glu Leu Lys Lys Glu 
            100                 105                 110         


Leu Glu Lys Tyr Gln Gly Leu Gln Gln Gln Glu Ala Lys Pro Asp Gly 
        115                 120                 125             


Leu Val Thr Asp Ser Ser Ala Glu Leu Gln Ser Leu Glu Gln Gln Leu 
    130                 135                 140                 


Glu Glu Ala Gln Thr Glu Asn Phe Asn Ile Lys Gln Met Lys Asp Leu 
145                 150                 155                 160 


Phe Glu Gln Lys Ala Ala Gln Leu Ala Thr Glu Ile Ala Asp Ile Lys 
                165                 170                 175     


Ser Lys Tyr Asp Glu Glu Arg Ser Leu Arg Glu Ala Ala Glu Gln Lys 
            180                 185                 190         


Val Thr Arg Leu Thr Glu Glu Leu Asn Lys Glu Ala Thr Val Ile Gln 
        195                 200                 205             


Asp Leu Lys Thr Glu Leu Leu Gln Arg Pro Gly Ile Glu Asp Val Ala 
    210                 215                 220                 


Val Leu Lys Lys Glu Leu Val Gln Val Gln Thr Leu Met Asp Asn Met 
225                 230                 235                 240 


Thr Leu Glu Arg Glu Arg Glu Ser Glu Lys Leu Lys Asp Glu Cys Lys 
                245                 250                 255     


Lys Leu Gln Ser Gln Tyr Ala Ser Ser Glu Ala Thr Ile Ser Gln Leu 
            260                 265                 270         


Arg Ser Glu Leu Ala Lys Gly Pro Gln Glu Val Ala Val Tyr Val Gln 
        275                 280                 285             


Glu Leu Gln Lys Leu Lys Ser Ser Val Asn Glu Leu Thr Gln Lys Asn 
    290                 295                 300                 


Gln Thr Leu Thr Glu Asn Leu Leu Lys Lys Glu Gln Asp Tyr Thr Lys 
305                 310                 315                 320 


Leu Glu Glu Lys His Asn Glu Glu Ser Val Ser Lys Lys Asn Ile Gln 
                325                 330                 335     


Ala Thr Leu His Gln Lys Asp Leu Asp Cys Gln Gln Leu Gln Ser Arg 
            340                 345                 350         


Leu Ser Ala Ser Glu Thr Ser Leu His Arg Ile His Val Glu Leu Ser 
        355                 360                 365             


Glu Lys Gly Glu Ala Thr Gln Lys Leu Lys Glu Glu Leu Ser Glu Val 
    370                 375                 380                 


Glu Thr Lys Tyr Gln His Leu Lys Ala Glu Phe Lys Gln Leu Gln Gln 
385                 390                 395                 400 


Gln Arg Glu Glu Lys Glu Gln His Gly Leu Gln Leu Gln Ser Glu Ile 
                405                 410                 415     


Asn Gln Leu His Ser Lys Leu Leu Glu Thr Glu Arg Gln Leu Gly Glu 
            420                 425                 430         


Ala His Gly Arg Leu Lys Glu Gln Arg Gln Leu Ser Ser Glu Lys Leu 
        435                 440                 445             


Met Asp Lys Glu Gln Gln Val Ala Asp Leu Gln Leu Lys Leu Ser Arg 
    450                 455                 460                 


Leu Glu Glu Gln Leu Lys Glu Lys Val Thr Asn Ser Thr Glu Leu Gln 
465                 470                 475                 480 


His Gln Leu Asp Lys Thr Lys Gln Gln His Gln Glu Gln Gln Ala Leu 
                485                 490                 495     


Gln Gln Ser Thr Thr Ala Lys Leu Arg Glu Ala Gln Asn Asp Leu Glu 
            500                 505                 510         


Gln Val Leu Arg Gln Ile Gly Asp Lys Asp Gln Lys Ile Gln Asn Leu 
        515                 520                 525             


Glu Ala Leu Leu Gln Lys Ser Lys Glu Asn Ile Ser Leu Leu Glu Lys 
    530                 535                 540                 


Glu Arg Glu Asp Leu Tyr Ala Lys Ile Gln Ala Gly Glu Gly Glu Thr 
545                 550                 555                 560 


Ala Val Leu Asn Gln Leu Gln Glu Lys Asn His Thr Leu Gln Glu Gln 
                565                 570                 575     


Val Thr Gln Leu Thr Glu Lys Leu Lys Asn Gln Ser Glu Ser His Lys 
            580                 585                 590         


Gln Ala Gln Glu Asn Leu His Asp Gln Val Gln Glu Gln Lys Ala His 
        595                 600                 605             


Leu Arg Ala Ala Gln Asp Arg Val Leu Ser Leu Glu Thr Ser Val Asn 
    610                 615                 620                 


Glu Leu Asn Ser Gln Leu Asn Glu Ser Lys Glu Lys Val Ser Gln Leu 
625                 630                 635                 640 


Asp Ile Gln Ile Lys Ala Lys Thr Glu Leu Leu Leu Ser Ala Glu Ala 
                645                 650                 655     


Ala Lys Thr Ala Gln Arg Ala Asp Leu Gln Asn His Leu Asp Thr Ala 
            660                 665                 670         


Gln Asn Ala Leu Gln Asp Lys Gln Gln Glu Leu Asn Lys Ile Thr Thr 
        675                 680                 685             


Gln Leu Asp Gln Val Thr Ala Lys Leu Gln Asp Lys Gln Glu His Cys 
    690                 695                 700                 


Ser Gln Leu Glu Ser His Leu Lys Glu Tyr Lys Glu Lys Tyr Leu Ser 
705                 710                 715                 720 


Leu Glu Gln Lys Thr Glu Glu Leu Glu Gly Gln Ile Lys Lys Leu Glu 
                725                 730                 735     


Ala Asp Ser Leu Glu Val Lys Ala Ser Lys Glu Gln Ala Leu Gln Asp 
            740                 745                 750         


Leu Gln Gln Gln Arg Gln Leu Asn Thr Asp Leu Glu Leu Arg Ala Thr 
        755                 760                 765             


Glu Leu Ser Lys Gln Leu Glu Met Glu Lys Glu Ile Val Ser Ser Thr 
    770                 775                 780                 


Arg Leu Asp Leu Gln Lys Lys Ser Glu Ala Leu Glu Ser Ile Lys Gln 
785                 790                 795                 800 


Lys Leu Thr Lys Gln Glu Glu Glu Lys Gln Ile Leu Lys Gln Asp Phe 
                805                 810                 815     


Glu Thr Leu Ser Gln Glu Thr Lys Ile Gln His Glu Glu Leu Asn Asn 
            820                 825                 830         


Arg Ile Gln Thr Thr Val Thr Glu Leu Gln Lys Val Lys Met Glu Lys 
        835                 840                 845             


Glu Ala Leu Met Thr Glu Leu Ser Thr Val Lys Asp Lys Leu Ser Lys 
    850                 855                 860                 


Val Ser Asp Ser Leu Lys Asn Ser Lys Ser Glu Phe Glu Lys Glu Asn 
865                 870                 875                 880 


Gln Lys Gly Lys Ala Ala Ile Leu Asp Leu Glu Lys Thr Cys Lys Glu 
                885                 890                 895     


Leu Lys His Gln Leu Gln Val Gln Met Glu Asn Thr Leu Lys Glu Gln 
            900                 905                 910         


Lys Glu Leu Lys Lys Ser Leu Glu Lys Glu Lys Glu Ala Ser His Gln 
        915                 920                 925             


Leu Lys Leu Glu Leu Asn Ser Met Gln Glu Gln Leu Ile Gln Ala Gln 
    930                 935                 940                 


Asn Thr Leu Lys Gln Asn Glu Lys Glu Glu Gln Gln Leu Gln Gly Asn 
945                 950                 955                 960 


Ile Asn Glu Leu Lys Gln Ser Ser Glu Gln Lys Lys Lys Gln Ile Glu 
                965                 970                 975     


Ala Leu Gln Gly Glu Leu Lys Ile Ala Val Leu Gln Lys Thr Glu Leu 
            980                 985                 990         


Glu Asn Lys Leu Gln Gln Gln Leu  Thr Gln Ala Ala Gln  Glu Leu Ala 
        995                 1000                 1005             


Ala Glu  Lys Glu Lys Ile Ser  Val Leu Gln Asn Asn  Tyr Glu Lys 
    1010                 1015                 1020             


Ser Gln  Glu Thr Phe Lys Gln  Leu Gln Ser Asp Phe  Tyr Gly Arg 
    1025                 1030                 1035             


Glu Ser  Glu Leu Leu Ala Thr  Arg Gln Asp Leu Lys  Ser Val Glu 
    1040                 1045                 1050             


Glu Lys  Leu Ser Leu Ala Gln  Glu Asp Leu Ile Ser  Asn Arg Asn 
    1055                 1060                 1065             


Gln Ile  Gly Asn Gln Asn Lys  Leu Ile Gln Glu Leu  Lys Thr Ala 
    1070                 1075                 1080             


Lys Ala  Thr Leu Glu Gln Asp  Ser Ala Lys Lys Glu  Gln Gln Leu 
    1085                 1090                 1095             


Gln Glu  Arg Cys Lys Ala Leu  Gln Asp Ile Gln Lys  Glu Lys Ser 
    1100                 1105                 1110             


Leu Lys  Glu Lys Glu Leu Val  Asn Glu Lys Ser Lys  Leu Ala Glu 
    1115                 1120                 1125             


Ile Glu  Glu Ile Lys Cys Arg  Gln Glu Lys Glu Ile  Thr Lys Leu 
    1130                 1135                 1140             


Asn Glu  Glu Leu Lys Ser His  Lys Leu Glu Ser Ile  Lys Glu Ile 
    1145                 1150                 1155             


Thr Asn  Leu Lys Asp Ala Lys  Gln Leu Leu Ile Gln  Gln Lys Leu 
    1160                 1165                 1170             


Glu Leu  Gln Gly Lys Ala Asp  Ser Leu Lys Ala Ala  Val Glu Gln 
    1175                 1180                 1185             


Glu Lys  Arg Asn Gln Gln Ile  Leu Lys Asp Gln Val  Lys Lys Glu 
    1190                 1195                 1200             


Glu Glu  Glu Leu Lys Lys Glu  Phe Ile Glu Lys Glu  Ala Lys Leu 
    1205                 1210                 1215             


His Ser  Glu Ile Lys Glu Lys  Glu Val Gly Met Lys  Lys His Glu 
    1220                 1225                 1230             


Glu Asn  Glu Ala Lys Leu Thr  Met Gln Ile Thr Ala  Leu Asn Glu 
    1235                 1240                 1245             


Asn Leu  Gly Thr Val Lys Lys  Glu Trp Gln Ser Ser  Gln Arg Arg 
    1250                 1255                 1260             


Val Ser  Glu Leu Glu Lys Gln  Thr Asp Asp Leu Arg  Gly Glu Ile 
    1265                 1270                 1275             


Ala Val  Leu Glu Ala Thr Val  Gln Asn Asn Gln Asp  Glu Arg Arg 
    1280                 1285                 1290             


Ala Leu  Leu Glu Arg Cys Leu  Lys Gly Glu Gly Glu  Ile Glu Lys 
    1295                 1300                 1305             


Leu Gln  Thr Lys Val Leu Glu  Leu Gln Arg Lys Leu  Asp Asn Thr 
    1310                 1315                 1320             


Thr Ala  Ala Val Gln Glu Leu  Gly Arg Glu Asn Gln  Ser Leu Gln 
    1325                 1330                 1335             


Ile Lys  His Thr Gln Ala Leu  Asn Arg Lys Trp Ala  Glu Asp Asn 
    1340                 1345                 1350             


Glu Val  Gln Asn Cys Met Ala  Cys Gly Lys Gly Phe  Ser Val Thr 
    1355                 1360                 1365             


Val Arg  Arg His His Cys Arg  Gln Cys Gly Asn Ile  Phe Cys Ala 
    1370                 1375                 1380             


Glu Cys  Ser Ala Lys Asn Ala  Leu Thr Pro Ser Ser  Lys Lys Pro 
    1385                 1390                 1395             


Val Arg  Val Cys Asp Ala Cys  Phe Asn Asp Leu Gln  Gly 
    1400                 1405                 1410     


<210>  3392
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EED__Homo_sapiens__NP_003788

<400>  3392

Met Ser Glu Arg Glu Val Ser Thr Ala Pro Ala Gly Thr Asp Met Pro 
1               5                   10                  15      


Ala Ala Lys Lys Gln Lys Leu Ser Ser Asp Glu Asn Ser Asn Pro Asp 
            20                  25                  30          


Leu Ser Gly Asp Glu Asn Asp Asp Ala Val Ser Ile Glu Ser Gly Thr 
        35                  40                  45              


Asn Thr Glu Arg Pro Asp Thr Pro Thr Asn Thr Pro Asn Ala Pro Gly 
    50                  55                  60                  


Arg Lys Ser Trp Gly Lys Gly Lys Trp Lys Ser Lys Lys Cys Lys Tyr 
65                  70                  75                  80  


Ser Phe Lys Cys Val Asn Ser Leu Lys Glu Asp His Asn Gln Pro Leu 
                85                  90                  95      


Phe Gly Val Gln Phe Asn Trp His Ser Lys Glu Gly Asp Pro Leu Val 
            100                 105                 110         


Phe Ala Thr Val Gly Ser Asn Arg Val Thr Leu Tyr Glu Cys His Ser 
        115                 120                 125             


Gln Gly Glu Ile Arg Leu Leu Gln Ser Tyr Val Asp Ala Asp Ala Asp 
    130                 135                 140                 


Glu Asn Phe Tyr Thr Cys Ala Trp Thr Tyr Asp Ser Asn Thr Ser His 
145                 150                 155                 160 


Pro Leu Leu Ala Val Ala Gly Ser Arg Gly Ile Ile Arg Ile Ile Asn 
                165                 170                 175     


Pro Ile Thr Met Gln Cys Ile Lys His Tyr Val Gly His Gly Asn Ala 
            180                 185                 190         


Ile Asn Glu Leu Lys Phe His Pro Arg Asp Pro Asn Leu Leu Leu Ser 
        195                 200                 205             


Val Ser Lys Asp His Ala Leu Arg Leu Trp Asn Ile Gln Thr Asp Thr 
    210                 215                 220                 


Leu Val Ala Ile Phe Gly Gly Val Glu Gly His Arg Asp Glu Val Leu 
225                 230                 235                 240 


Ser Ala Asp Tyr Asp Leu Leu Gly Glu Lys Ile Met Ser Cys Gly Met 
                245                 250                 255     


Asp His Ser Leu Lys Leu Trp Arg Ile Asn Ser Lys Arg Met Met Asn 
            260                 265                 270         


Ala Ile Lys Glu Ser Tyr Asp Tyr Asn Pro Asn Lys Thr Asn Arg Pro 
        275                 280                 285             


Phe Ile Ser Gln Lys Ile His Phe Pro Asp Phe Ser Thr Arg Asp Ile 
    290                 295                 300                 


His Arg Asn Tyr Val Asp Cys Val Arg Trp Leu Gly Asp Leu Ile Leu 
305                 310                 315                 320 


Ser Lys Ser Cys Glu Asn Ala Ile Val Cys Trp Lys Pro Gly Lys Met 
                325                 330                 335     


Glu Asp Asp Ile Asp Lys Ile Lys Pro Ser Glu Ser Asn Val Thr Ile 
            340                 345                 350         


Leu Gly Arg Phe Asp Tyr Ser Gln Cys Asp Ile Trp Tyr Met Arg Phe 
        355                 360                 365             


Ser Met Asp Phe Trp Gln Lys Met Leu Ala Leu Gly Asn Gln Val Gly 
    370                 375                 380                 


Lys Leu Tyr Val Trp Asp Leu Glu Val Glu Asp Pro His Lys Ala Lys 
385                 390                 395                 400 


Cys Thr Thr Leu Thr His His Lys Cys Gly Ala Ala Ile Arg Gln Thr 
                405                 410                 415     


Ser Phe Ser Arg Asp Ser Ser Ile Leu Ile Ala Val Cys Asp Asp Ala 
            420                 425                 430         


Ser Ile Trp Arg Trp Asp Arg Leu Arg 
        435                 440     


<210>  3393
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEF1A1__Homo_sapiens__XP_011533816

<400>  3393

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
    210                 215                 220                 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
            260                 265                 270         


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
305                 310                 315                 320 


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                325                 330                 335     


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
    450                 455                 460         


<210>  3394
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEF1A2__Homo_sapiens__NP_001949

<400>  3394

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Thr Lys Tyr Tyr Ile Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Ala Tyr Ser Glu Lys Arg Tyr Asp Glu Ile Val Lys Glu Val Ser Ala 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Ala Thr Val Pro Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp His Gly Asp Asn Met Leu Glu Pro Ser Pro Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Glu Arg Lys Glu Gly Asn Ala Ser 
    210                 215                 220                 


Gly Val Ser Leu Leu Glu Ala Leu Asp Thr Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Ile Leu 
            260                 265                 270         


Arg Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Ile Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Ile 
305                 310                 315                 320 


Arg Arg Gly Asn Val Cys Gly Asp Ser Lys Ser Asp Pro Pro Gln Glu 
                325                 330                 335     


Ala Ala Gln Phe Thr Ser Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ser Pro Val Ile Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Asn Pro Lys Ser Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Glu Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Gln Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Asn Val Glu Lys Lys Ser Gly Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Gly Lys 
    450                 455                 460             


<210>  3395
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEF1B2__Homo_sapiens__NP_001032752

<400>  3395

Met Gly Phe Gly Asp Leu Lys Ser Pro Ala Gly Leu Gln Val Leu Asn 
1               5                   10                  15      


Asp Tyr Leu Ala Asp Lys Ser Tyr Ile Glu Gly Tyr Val Pro Ser Gln 
            20                  25                  30          


Ala Asp Val Ala Val Phe Glu Ala Val Ser Ser Pro Pro Pro Ala Asp 
        35                  40                  45              


Leu Cys His Ala Leu Arg Trp Tyr Asn His Ile Lys Ser Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ala Ser Leu Pro Gly Val Lys Lys Ala Leu Gly Lys Tyr Gly 
65                  70                  75                  80  


Pro Ala Asp Val Glu Asp Thr Thr Gly Ser Gly Ala Thr Asp Ser Lys 
                85                  90                  95      


Asp Asp Asp Asp Ile Asp Leu Phe Gly Ser Asp Asp Glu Glu Glu Ser 
            100                 105                 110         


Glu Glu Ala Lys Arg Leu Arg Glu Glu Arg Leu Ala Gln Tyr Glu Ser 
        115                 120                 125             


Lys Lys Ala Lys Lys Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu 
    130                 135                 140                 


Asp Val Lys Pro Trp Asp Asp Glu Thr Asp Met Ala Lys Leu Glu Glu 
145                 150                 155                 160 


Cys Val Arg Ser Ile Gln Ala Asp Gly Leu Val Trp Gly Ser Ser Lys 
                165                 170                 175     


Leu Val Pro Val Gly Tyr Gly Ile Lys Lys Leu Gln Ile Gln Cys Val 
            180                 185                 190         


Val Glu Asp Asp Lys Val Gly Thr Asp Met Leu Glu Glu Gln Ile Thr 
        195                 200                 205             


Ala Phe Glu Asp Tyr Val Gln Ser Met Asp Val Ala Ala Phe Asn Lys 
    210                 215                 220                 


Ile 
225 


<210>  3396
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEF1D__Homo_sapiens__NP_001123525

<400>  3396

Met Arg Ser Gly Lys Ala Ser Cys Thr Leu Glu Thr Val Trp Glu Asp 
1               5                   10                  15      


Lys His Lys Tyr Glu Glu Ala Glu Arg Arg Phe Tyr Glu His Glu Ala 
            20                  25                  30          


Thr Gln Ala Ala Ala Ser Ala Gln Gln Leu Pro Ala Glu Gly Pro Ala 
        35                  40                  45              


Met Asn Gly Pro Gly Gln Asp Asp Pro Glu Asp Ala Asp Glu Ala Glu 
    50                  55                  60                  


Ala Pro Asp Gly Gly Ser Arg Arg Asp Pro Arg Lys Ser Gln Asp Ser 
65                  70                  75                  80  


Arg Lys Pro Leu Gln Lys Lys Arg Lys Arg Ser Pro Lys Ser Gly Leu 
                85                  90                  95      


Gly Pro Ala Asp Leu Ala Leu Leu Gly Leu Ser Ala Glu Arg Val Trp 
            100                 105                 110         


Leu Asp Lys Ser Leu Phe Asp Gln Ala Glu Ser Ser Tyr Arg Gln Lys 
        115                 120                 125             


Leu Ala Asp Val Ala Ala Gln Ala Ala Trp Pro Pro Ala Leu Ala Pro 
    130                 135                 140                 


Trp Gly Leu Cys Thr His Gly Asn Gln Val Ala Cys His His Val Thr 
145                 150                 155                 160 


Trp Gly Ile Trp Val Asn Lys Ser Ser Phe Asp Gln Ala Glu Arg Ala 
                165                 170                 175     


Phe Val Glu Trp Ser Gln Ala Leu Leu Leu Ala Pro Glu Gly Ser Arg 
            180                 185                 190         


Arg Gln Gly Thr Pro Asn Thr Gly Gln Gln Val Ala Val Pro Asp Leu 
        195                 200                 205             


Ala His Gln Pro Ser Pro Pro Val Asn Gly Gln Pro Pro Leu Gly Ser 
    210                 215                 220                 


Leu Gln Ala Leu Val Arg Glu Val Trp Leu Glu Lys Pro Arg Tyr Asp 
225                 230                 235                 240 


Ala Ala Glu Arg Gly Phe Tyr Glu Ala Leu Phe Asp Gly His Pro Pro 
                245                 250                 255     


Gly Lys Val Arg Leu Gln Glu Arg Ala Gly Leu Ala Glu Gly Ala Arg 
            260                 265                 270         


Arg Gly Arg Arg Asp Arg Arg Gly Arg Asn Ile Leu Gly Asn Lys Arg 
        275                 280                 285             


Ala Gly Leu Arg Arg Ala Asp Gly Glu Ala Pro Ser Ala Leu Pro Tyr 
    290                 295                 300                 


Cys Tyr Phe Leu Gln Lys Asp Ala Glu Ala Pro Trp Leu Ser Lys Pro 
305                 310                 315                 320 


Ala Tyr Asp Ser Ala Glu Cys Arg His His Ala Ala Glu Ala Leu Arg 
                325                 330                 335     


Val Ala Trp Cys Leu Glu Ala Ala Ser Leu Ser His Arg Pro Gly Pro 
            340                 345                 350         


Arg Ser Gly Leu Ser Val Ser Ser Leu Arg Pro Asn Arg Lys Met Ala 
        355                 360                 365             


Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe Lys Tyr 
    370                 375                 380                 


Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro Val Ala 
385                 390                 395                 400 


Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg Asp Ile 
                405                 410                 415     


Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser Ser Gly 
            420                 425                 430         


Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu Val Val 
        435                 440                 445             


Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly Val Val 
    450                 455                 460                 


Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu Asn Val 
465                 470                 475                 480 


Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln Thr Gln 
                485                 490                 495     


His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys Pro Ala 
            500                 505                 510         


Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe Gly Ser 
        515                 520                 525             


Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu Glu Arg 
    530                 535                 540                 


Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu Val Ala 
545                 550                 555                 560 


Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu Thr Asp 
                565                 570                 575     


Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp Gly Leu 
            580                 585                 590         


Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile Arg Lys 
        595                 600                 605             


Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr Asp Leu 
    610                 615                 620                 


Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser Val Asp 
625                 630                 635                 640 


Ile Ala Ala Phe Asn Lys Ile 
                645         


<210>  3397
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEF1E1__Homo_sapiens__NP_001129122

<400>  3397

Met Ala Ala Ala Ala Glu Leu Ser Leu Leu Glu Lys Ser Leu Gly Leu 
1               5                   10                  15      


Ser Lys Gly Asn Lys Tyr Ser Ala Gln Gly Glu Arg Gln Ile Pro Val 
            20                  25                  30          


Leu Gln Thr Asn Asn Gly Pro Ser Leu Thr Gly Leu Thr Thr Ile Ala 
        35                  40                  45              


Ala His Leu Val Lys Gln Ala Asn Lys Glu Tyr Leu Leu Gly Ser Thr 
    50                  55                  60                  


Ala Glu Glu Lys Ala Ile Val Gln Gln Trp Leu Glu Tyr Arg Val Thr 
65                  70                  75                  80  


Gln Val Asp Gly His Ser Ser Lys Asn Asp Ile His Thr Leu Leu Lys 
                85                  90                  95      


Asp Leu Asn Ser Tyr Leu Glu Asp Lys Val Tyr Leu Thr Gly Tyr Asn 
            100                 105                 110         


Phe Thr Leu Ala Asp Ile Leu Leu Tyr Tyr Gly Leu His Arg Phe Ile 
        115                 120                 125             


Ile Arg Lys Leu Arg His Thr Glu Val Gly Asn 
    130                 135                 


<210>  3398
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEF1G__Homo_sapiens__NP_001395

<400>  3398

Met Ala Ala Gly Thr Leu Tyr Thr Tyr Pro Glu Asn Trp Arg Ala Phe 
1               5                   10                  15      


Lys Ala Leu Ile Ala Ala Gln Tyr Ser Gly Ala Gln Val Arg Val Leu 
            20                  25                  30          


Ser Ala Pro Pro His Phe His Phe Gly Gln Thr Asn Arg Thr Pro Glu 
        35                  40                  45              


Phe Leu Arg Lys Phe Pro Ala Gly Lys Val Pro Ala Phe Glu Gly Asp 
    50                  55                  60                  


Asp Gly Phe Cys Val Phe Glu Ser Asn Ala Ile Ala Tyr Tyr Val Ser 
65                  70                  75                  80  


Asn Glu Glu Leu Arg Gly Ser Thr Pro Glu Ala Ala Ala Gln Val Val 
                85                  90                  95      


Gln Trp Val Ser Phe Ala Asp Ser Asp Ile Val Pro Pro Ala Ser Thr 
            100                 105                 110         


Trp Val Phe Pro Thr Leu Gly Ile Met His His Asn Lys Gln Ala Thr 
        115                 120                 125             


Glu Asn Ala Lys Glu Glu Val Arg Arg Ile Leu Gly Leu Leu Asp Ala 
    130                 135                 140                 


Tyr Leu Lys Thr Arg Thr Phe Leu Val Gly Glu Arg Val Thr Leu Ala 
145                 150                 155                 160 


Asp Ile Thr Val Val Cys Thr Leu Leu Trp Leu Tyr Lys Gln Val Leu 
                165                 170                 175     


Glu Pro Ser Phe Arg Gln Ala Phe Pro Asn Thr Asn Arg Trp Phe Leu 
            180                 185                 190         


Thr Cys Ile Asn Gln Pro Gln Phe Arg Ala Val Leu Gly Glu Val Lys 
        195                 200                 205             


Leu Cys Glu Lys Met Ala Gln Phe Asp Ala Lys Lys Phe Ala Glu Thr 
    210                 215                 220                 


Gln Pro Lys Lys Asp Thr Pro Arg Lys Glu Lys Gly Ser Arg Glu Glu 
225                 230                 235                 240 


Lys Gln Lys Pro Gln Ala Glu Arg Lys Glu Glu Lys Lys Ala Ala Ala 
                245                 250                 255     


Pro Ala Pro Glu Glu Glu Met Asp Glu Cys Glu Gln Ala Leu Ala Ala 
            260                 265                 270         


Glu Pro Lys Ala Lys Asp Pro Phe Ala His Leu Pro Lys Ser Thr Phe 
        275                 280                 285             


Val Leu Asp Glu Phe Lys Arg Lys Tyr Ser Asn Glu Asp Thr Leu Ser 
    290                 295                 300                 


Val Ala Leu Pro Tyr Phe Trp Glu His Phe Asp Lys Asp Gly Trp Ser 
305                 310                 315                 320 


Leu Trp Tyr Ser Glu Tyr Arg Phe Pro Glu Glu Leu Thr Gln Thr Phe 
                325                 330                 335     


Met Ser Cys Asn Leu Ile Thr Gly Met Phe Gln Arg Leu Asp Lys Leu 
            340                 345                 350         


Arg Lys Asn Ala Phe Ala Ser Val Ile Leu Phe Gly Thr Asn Asn Ser 
        355                 360                 365             


Ser Ser Ile Ser Gly Val Trp Val Phe Arg Gly Gln Glu Leu Ala Phe 
    370                 375                 380                 


Pro Leu Ser Pro Asp Trp Gln Val Asp Tyr Glu Ser Tyr Thr Trp Arg 
385                 390                 395                 400 


Lys Leu Asp Pro Gly Ser Glu Glu Thr Gln Thr Leu Val Arg Glu Tyr 
                405                 410                 415     


Phe Ser Trp Glu Gly Ala Phe Gln His Val Gly Lys Ala Phe Asn Gln 
            420                 425                 430         


Gly Lys Ile Phe Lys 
        435         


<210>  3399
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEF2__Homo_sapiens__NP_001952

<400>  3399

Met Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys 
1               5                   10                  15      


Ala Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys 
            20                  25                  30          


Ser Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser 
        35                  40                  45              


Ala Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln 
    50                  55                  60                  


Glu Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu 
65                  70                  75                  80  


Leu Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala 
                85                  90                  95      


Gly Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser 
            100                 105                 110         


Ser Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val 
        115                 120                 125             


Val Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg 
    130                 135                 140                 


Gln Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met 
145                 150                 155                 160 


Asp Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln 
                165                 170                 175     


Thr Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr 
            180                 185                 190         


Gly Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val 
        195                 200                 205             


Leu Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr 
    210                 215                 220                 


Leu Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly 
225                 230                 235                 240 


Glu Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met 
                245                 250                 255     


Met Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys 
            260                 265                 270         


Phe Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr 
        275                 280                 285             


Phe Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile 
    290                 295                 300                 


Met Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp 
305                 310                 315                 320 


Ile Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu 
                325                 330                 335     


Lys Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln 
            340                 345                 350         


Met Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg 
        355                 360                 365             


Cys Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly 
    370                 375                 380                 


Ile Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys 
385                 390                 395                 400 


Met Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val 
                405                 410                 415     


Phe Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro 
            420                 425                 430         


Asn Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln 
        435                 440                 445             


Arg Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val 
    450                 455                 460                 


Pro Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val 
465                 470                 475                 480 


Lys Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val 
                485                 490                 495     


Met Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys 
            500                 505                 510         


Asn Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala 
        515                 520                 525             


Lys Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His 
    530                 535                 540                 


Ile Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp 
545                 550                 555                 560 


Leu Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val 
                565                 570                 575     


Val Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu 
            580                 585                 590         


Ser Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro 
        595                 600                 605             


Phe Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala 
    610                 615                 620                 


Arg Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu 
625                 630                 635                 640 


Trp Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly 
                645                 650                 655     


Thr Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu 
            660                 665                 670         


Asn Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys 
        675                 680                 685             


Glu Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val 
    690                 695                 700                 


His Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln 
705                 710                 715                 720 


Ile Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala 
                725                 730                 735     


Gln Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro 
            740                 745                 750         


Glu Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly 
        755                 760                 765             


His Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val 
    770                 775                 780                 


Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu 
785                 790                 795                 800 


Arg Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His 
                805                 810                 815     


Trp Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser 
            820                 825                 830         


Gln Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile 
        835                 840                 845             


Pro Ala Leu Asp Asn Phe Leu Asp Lys Leu 
    850                 855             


<210>  3400
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEFSEC__Homo_sapiens__NP_068756

<400>  3400

Met Ala Gly Arg Arg Val Asn Val Asn Val Gly Val Leu Gly His Ile 
1               5                   10                  15      


Asp Ser Gly Lys Thr Ala Leu Ala Arg Ala Leu Ser Thr Thr Ala Ser 
            20                  25                  30          


Thr Ala Ala Phe Asp Lys Gln Pro Gln Ser Arg Glu Arg Gly Ile Thr 
        35                  40                  45              


Leu Asp Leu Gly Phe Ser Cys Phe Ser Val Pro Leu Pro Ala Arg Leu 
    50                  55                  60                  


Arg Ser Ser Leu Pro Glu Phe Gln Ala Ala Pro Glu Ala Glu Pro Glu 
65                  70                  75                  80  


Pro Gly Glu Pro Leu Leu Gln Val Thr Leu Val Asp Cys Pro Gly His 
                85                  90                  95      


Ala Ser Leu Ile Arg Thr Ile Ile Gly Gly Ala Gln Ile Ile Asp Leu 
            100                 105                 110         


Met Met Leu Val Ile Asp Val Thr Lys Gly Met Gln Thr Gln Ser Ala 
        115                 120                 125             


Glu Cys Leu Val Ile Gly Gln Ile Ala Cys Gln Lys Leu Val Val Val 
    130                 135                 140                 


Leu Asn Lys Ile Asp Leu Leu Pro Glu Gly Lys Arg Gln Ala Ala Ile 
145                 150                 155                 160 


Asp Lys Met Thr Lys Lys Met Gln Lys Thr Leu Glu Asn Thr Lys Phe 
                165                 170                 175     


Arg Gly Ala Pro Ile Ile Pro Val Ala Ala Lys Pro Gly Gly Pro Glu 
            180                 185                 190         


Ala Pro Glu Thr Glu Ala Pro Gln Gly Ile Pro Glu Leu Ile Glu Leu 
        195                 200                 205             


Leu Thr Ser Gln Ile Ser Ile Pro Thr Arg Asp Pro Ser Gly Pro Phe 
    210                 215                 220                 


Leu Met Ser Val Asp His Cys Phe Ser Ile Lys Gly Gln Gly Thr Val 
225                 230                 235                 240 


Met Thr Gly Thr Ile Leu Ser Gly Ser Ile Ser Leu Gly Asp Ser Val 
                245                 250                 255     


Glu Ile Pro Ala Leu Lys Val Val Lys Lys Val Lys Ser Met Gln Met 
            260                 265                 270         


Phe His Met Pro Ile Thr Ser Ala Met Gln Gly Asp Arg Leu Gly Ile 
        275                 280                 285             


Cys Val Thr Gln Phe Asp Pro Lys Leu Leu Glu Arg Gly Leu Val Cys 
    290                 295                 300                 


Ala Pro Glu Ser Leu His Thr Val His Ala Ala Leu Ile Ser Val Glu 
305                 310                 315                 320 


Lys Ile Pro Tyr Phe Arg Gly Pro Leu Gln Thr Lys Ala Lys Phe His 
                325                 330                 335     


Ile Thr Val Gly His Glu Thr Val Met Gly Arg Leu Met Phe Phe Ser 
            340                 345                 350         


Pro Ala Pro Asp Asn Phe Asp Gln Glu Pro Ile Leu Asp Ser Phe Asn 
        355                 360                 365             


Phe Ser Gln Glu Tyr Leu Phe Gln Glu Gln Tyr Leu Ser Lys Asp Leu 
    370                 375                 380                 


Thr Pro Ala Val Thr Asp Asn Asp Glu Ala Asp Lys Lys Ala Gly Gln 
385                 390                 395                 400 


Ala Thr Glu Gly His Cys Pro Arg Gln Gln Trp Ala Leu Val Glu Phe 
                405                 410                 415     


Glu Lys Pro Val Thr Cys Pro Arg Leu Cys Leu Val Ile Gly Ser Arg 
            420                 425                 430         


Leu Asp Ala Asp Ile His Thr Asn Thr Cys Arg Leu Ala Phe His Gly 
        435                 440                 445             


Ile Leu Leu His Gly Leu Glu Asp Arg Asn Tyr Ala Asp Ser Phe Leu 
    450                 455                 460                 


Pro Arg Leu Lys Val Tyr Lys Leu Lys His Lys His Gly Leu Val Glu 
465                 470                 475                 480 


Arg Ala Met Asp Asp Tyr Ser Val Ile Gly Arg Ser Leu Phe Lys Lys 
                485                 490                 495     


Glu Thr Asn Ile Gln Leu Phe Val Gly Leu Lys Val His Leu Ser Thr 
            500                 505                 510         


Gly Glu Leu Gly Ile Ile Asp Ser Ala Phe Gly Gln Ser Gly Lys Phe 
        515                 520                 525             


Lys Ile His Ile Pro Gly Gly Leu Ser Pro Glu Ser Lys Lys Ile Leu 
    530                 535                 540                 


Thr Pro Ala Leu Lys Lys Arg Ala Arg Ala Gly Arg Gly Glu Ala Thr 
545                 550                 555                 560 


Arg Gln Glu Glu Ser Ala Glu Arg Ser Glu Pro Ser Gln His Val Val 
                565                 570                 575     


Leu Ser Leu Thr Phe Lys Arg Tyr Val Phe Asp Thr His Lys Arg Met 
            580                 585                 590         


Val Gln Ser Pro 
        595     


<210>  3401
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFCAB11__Homo_sapiens__NP_001271195

<400>  3401

Met Phe Phe Ser Glu Ala Arg Ala Arg Ser Arg Thr Trp Glu Ala Ser 
1               5                   10                  15      


Pro Ser Glu His Arg Lys Trp Val Glu Val Phe Lys Ala Cys Asp Glu 
            20                  25                  30          


Asp His Lys Gly Tyr Leu Ser Arg Glu Asp Phe Lys Thr Ala Val Val 
        35                  40                  45              


Met Leu Phe Gly Tyr Lys Pro Ser Lys Ile Glu Val Asp Ser Val Met 
    50                  55                  60                  


Ser Ser Ile Asn Pro Asn Thr Ser Gly Ile Leu Leu Glu Gly Phe Leu 
65                  70                  75                  80  


Asn Ile Val Arg Lys Lys Lys Glu Ala Gln Arg Tyr Arg Asn Glu Val 
                85                  90                  95      


Arg His Ile Phe Thr Ala Phe Asp Thr Tyr Tyr Arg Gly Phe Leu Thr 
            100                 105                 110         


Leu Glu Asp Phe Lys Lys Ala Phe Arg Gln Val Ala Pro Lys Leu Pro 
        115                 120                 125             


Glu Arg Thr Val Leu Glu Val Phe Arg Gly Ile Phe Ser Ala 
    130                 135                 140         


<210>  3402
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFCAB1__Homo_sapiens__XP_005251361

<400>  3402

Met Asn Arg Lys Lys Leu Gln Lys Leu Thr Asp Thr Leu Thr Lys Asn 
1               5                   10                  15      


Cys Lys His Leu Phe Arg Gly Phe Asp Lys Asp Asn Asp Gly Cys Val 
            20                  25                  30          


Asn Val Leu Glu Trp Ile His Gly Leu Ser Leu Phe Leu Arg Gly Ser 
        35                  40                  45              


Leu Glu Glu Lys Met Lys Tyr Cys Phe Glu Val Phe Asp Leu Asn Gly 
    50                  55                  60                  


Asp Gly Phe Ile Ser Lys Glu Glu Met Phe His Met Leu Lys Asn Ser 
65                  70                  75                  80  


Leu Leu Lys Gln Pro Ser Glu Glu Asp Pro Asp Glu Gly Ile Lys Asp 
                85                  90                  95      


Leu Val Glu Ile Thr Leu Lys Lys Met Asp His Asp His Asp Gly Lys 
            100                 105                 110         


Leu Ser Phe Ala Asp Tyr Glu Leu Ala Val Arg Glu Glu Thr Leu Leu 
        115                 120                 125             


Leu Glu Ala Phe Gly Pro Cys Leu Pro Asp Pro Lys Ser Gln Met Glu 
    130                 135                 140                 


Phe Glu Ala Gln Val Phe Lys Asp Pro Asn Glu Phe Asn Asp Met 
145                 150                 155                 


<210>  3403
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFEMP1__Homo_sapiens__NP_001034438

<400>  3403

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  3404
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFEMP2__Homo_sapiens__NP_058634

<400>  3404

Met Leu Pro Cys Ala Ser Cys Leu Pro Gly Ser Leu Leu Leu Trp Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Ser Ala Ser Pro Gln Asp Ser Glu Glu 
            20                  25                  30          


Pro Asp Ser Tyr Thr Glu Cys Thr Asp Gly Tyr Glu Trp Asp Pro Asp 
        35                  40                  45              


Ser Gln His Cys Arg Asp Val Asn Glu Cys Leu Thr Ile Pro Glu Ala 
    50                  55                  60                  


Cys Lys Gly Glu Met Lys Cys Ile Asn His Tyr Gly Gly Tyr Leu Cys 
65                  70                  75                  80  


Leu Pro Arg Ser Ala Ala Val Ile Asn Asp Leu His Gly Glu Gly Pro 
                85                  90                  95      


Pro Pro Pro Val Pro Pro Ala Gln His Pro Asn Pro Cys Pro Pro Gly 
            100                 105                 110         


Tyr Glu Pro Asp Asp Gln Asp Ser Cys Val Asp Val Asp Glu Cys Ala 
        115                 120                 125             


Gln Ala Leu His Asp Cys Arg Pro Ser Gln Asp Cys His Asn Leu Pro 
    130                 135                 140                 


Gly Ser Tyr Gln Cys Thr Cys Pro Asp Gly Tyr Arg Lys Ile Gly Pro 
145                 150                 155                 160 


Glu Cys Val Asp Ile Asp Glu Cys Arg Tyr Arg Tyr Cys Gln His Arg 
                165                 170                 175     


Cys Val Asn Leu Pro Gly Ser Phe Arg Cys Gln Cys Glu Pro Gly Phe 
            180                 185                 190         


Gln Leu Gly Pro Asn Asn Arg Ser Cys Val Asp Val Asn Glu Cys Asp 
        195                 200                 205             


Met Gly Ala Pro Cys Glu Gln Arg Cys Phe Asn Ser Tyr Gly Thr Phe 
    210                 215                 220                 


Leu Cys Arg Cys His Gln Gly Tyr Glu Leu His Arg Asp Gly Phe Ser 
225                 230                 235                 240 


Cys Ser Asp Ile Asp Glu Cys Ser Tyr Ser Ser Tyr Leu Cys Gln Tyr 
                245                 250                 255     


Arg Cys Ile Asn Glu Pro Gly Arg Phe Ser Cys His Cys Pro Gln Gly 
            260                 265                 270         


Tyr Gln Leu Leu Ala Thr Arg Leu Cys Gln Asp Ile Asp Glu Cys Glu 
        275                 280                 285             


Ser Gly Ala His Gln Cys Ser Glu Ala Gln Thr Cys Val Asn Phe His 
    290                 295                 300                 


Gly Gly Tyr Arg Cys Val Asp Thr Asn Arg Cys Val Glu Pro Tyr Ile 
305                 310                 315                 320 


Gln Val Ser Glu Asn Arg Cys Leu Cys Pro Ala Ser Asn Pro Leu Cys 
                325                 330                 335     


Arg Glu Gln Pro Ser Ser Ile Val His Arg Tyr Met Thr Ile Thr Ser 
            340                 345                 350         


Glu Arg Ser Val Pro Ala Asp Val Phe Gln Ile Gln Ala Thr Ser Val 
        355                 360                 365             


Tyr Pro Gly Ala Tyr Asn Ala Phe Gln Ile Arg Ala Gly Asn Ser Gln 
    370                 375                 380                 


Gly Asp Phe Tyr Ile Arg Gln Ile Asn Asn Val Ser Ala Met Leu Val 
385                 390                 395                 400 


Leu Ala Arg Pro Val Thr Gly Pro Arg Glu Tyr Val Leu Asp Leu Glu 
                405                 410                 415     


Met Val Thr Met Asn Ser Leu Met Ser Tyr Arg Ala Ser Ser Val Leu 
            420                 425                 430         


Arg Leu Thr Val Phe Val Gly Ala Tyr Thr Phe 
        435                 440             


<210>  3405
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFHB__Homo_sapiens__NP_653316

<400>  3405

Met Asn Met Glu Ile Gly His Pro His Glu Gly Lys Asp Asp Leu Gly 
1               5                   10                  15      


Asp Lys Arg Val Ile Met Gly Thr Lys Phe Pro Met Glu Leu Gly Ile 
            20                  25                  30          


Arg Val Gly Leu Gly Lys Glu Asp Ser Arg Cys Gly Glu Ser Pro Val 
        35                  40                  45              


Val Ser Asn Lys Cys Glu Gly Arg Met Ala Pro Pro Glu Thr Lys Phe 
    50                  55                  60                  


Pro Leu Ser Lys Gly Leu Glu Met Gly Leu Glu Arg Gln Asn Ile Ser 
65                  70                  75                  80  


Arg Thr Val Met Gln Arg Gly Ser Leu Gly Val Asp Ser Val Ser Ala 
                85                  90                  95      


Ser Gln Gly Thr Lys Pro Ser Leu Leu Pro Gly Arg Met Gly Leu Glu 
            100                 105                 110         


Asn Glu Ser Leu Leu Ala Gly Tyr Thr His Glu Arg Ile Ile Gln Pro 
        115                 120                 125             


Pro Leu Gly Arg Val Cys Gly Ser Ser Gln Ala Ala Gly Ser Arg Arg 
    130                 135                 140                 


Ala Pro Leu Ala Ser Gly Pro Glu Gly Val Glu Glu Leu Val Gly Lys 
145                 150                 155                 160 


Pro Ala Phe Val Met Glu Pro Arg Gln Glu Met Glu Lys Glu Ser Thr 
                165                 170                 175     


Cys Val Leu Met Lys Pro Asn Thr Glu Ile Lys Leu Pro Val Glu Val 
            180                 185                 190         


Asp Ile Gly Leu Thr Gln Ala Glu Gly Pro Asp Glu Thr Lys Asn Thr 
        195                 200                 205             


Glu Pro Gln Met Gly Leu Val Ile Glu Pro Pro Gln Cys Gln Phe Ala 
    210                 215                 220                 


Gln Gln His Glu Gln Arg Lys Glu Ala Gly Asn Ile Glu Ser Gly Val 
225                 230                 235                 240 


Glu Pro Pro Asp Arg Ile Arg Pro Ile Tyr Ser Gly Lys Phe Phe Asp 
                245                 250                 255     


Arg Thr Pro Cys Trp Pro Ser Ala Gly Lys Val Ile Pro Val Gly Tyr 
            260                 265                 270         


Arg Val Ala Thr Cys Leu Thr Glu Lys Leu Pro Arg Leu Ile Thr Pro 
        275                 280                 285             


Pro Glu Ala Lys Lys Tyr Phe Asn Phe Arg Tyr Pro Pro Ala Gly Val 
    290                 295                 300                 


Glu Arg Val Phe Tyr Gly Arg Ala Asn Asp Pro Gln Ile Ala Pro Tyr 
305                 310                 315                 320 


Leu Thr His Gly Ile Arg Ser Lys Ile Ser Val Leu Ala Asn Thr Leu 
                325                 330                 335     


Ile Asn Pro Gln Pro Ile Thr Thr Phe Gln Gln Lys Ile Lys Asp Lys 
            340                 345                 350         


Lys Glu Ser Ile Tyr Leu Ser Asn Arg Arg Ala Pro Leu Gly Lys Ser 
        355                 360                 365             


His Asp Gln Ala Pro Gly Leu Pro Lys Gly Met Asp Thr Thr Asn Thr 
    370                 375                 380                 


Thr Phe Gly Thr Ala Val Ile Lys Glu Tyr Ser Ala Lys Asp Val Val 
385                 390                 395                 400 


Asn Pro Pro Lys Ser Tyr Glu Glu Val Phe Lys Glu Gly Asn Glu Gly 
                405                 410                 415     


His Asp Leu Tyr Val Val Ser His Asn Asp Tyr Tyr Ala Gly Glu Ala 
            420                 425                 430         


Lys Asn Arg Lys Tyr Asn Pro Ser Ser Phe His Arg Cys Ser Val Tyr 
        435                 440                 445             


Gly Val Pro Thr Pro His Phe Asn Asp Gly Arg Ala Met Ala Lys Ser 
    450                 455                 460                 


Leu Tyr Trp Leu His Glu Leu Gln Met Lys Arg Gly Ala Lys Phe Val 
465                 470                 475                 480 


Ser Lys Arg Ala Asp Asp Phe Lys Glu Lys Phe Gln His Lys Leu Gly 
                485                 490                 495     


Arg Val Leu Asp Pro Ile Ala Glu Thr Met Asn Val Pro Pro Asp Cys 
            500                 505                 510         


Thr Phe Gly Ala Cys Leu Arg Pro Glu Glu Tyr Gly Val Gly Asp Leu 
        515                 520                 525             


Ile His Asn Arg Leu Pro Asp Glu Tyr Leu Arg Gly Lys Asp Arg Gln 
    530                 535                 540                 


Arg Ala Leu Ile Ala Ala Val Arg His His Leu Lys Lys Val Asn Tyr 
545                 550                 555                 560 


Gln Lys Phe Asp Thr Leu Leu Ala Ala Phe Arg His Tyr Asp Lys Lys 
                565                 570                 575     


Gly Asp Gly Met Ile Asp Lys Asp Glu Leu Gln Glu Ala Cys Asp Gln 
            580                 585                 590         


Ala Asn Leu Ser Leu Asp Asp Lys Leu Leu Asp Gln Leu Phe Asp Tyr 
        595                 600                 605             


Cys Asp Val Asp Asn Asp Gly Phe Ile Asn Tyr Leu Glu Phe Ala Asn 
    610                 615                 620                 


Phe Leu Asn Trp Lys Asp Lys Met Leu Leu Lys Glu Tyr Glu Glu Arg 
625                 630                 635                 640 


Val Ile Ile Lys Gly Arg Lys Pro Asp Cys Val Asn Pro Thr Glu Ala 
                645                 650                 655     


Asn Val Glu Glu Pro Glu Gln Thr Leu Leu Ile Lys Pro Glu Asp Ile 
            660                 665                 670         


Val Leu Lys Glu Ala Gly Ser Thr Glu Lys Thr Leu Arg Thr Leu Leu 
        675                 680                 685             


Arg Pro Ser Asp Lys Val Ser Asn Tyr Tyr Lys Thr Thr Ser Ser Glu 
    690                 695                 700                 


Ile Asn Ala Ile Val Gly Ala Ile Pro Ser Thr Cys Tyr Pro Ile Cys 
705                 710                 715                 720 


Gly Val Pro Thr Ile Arg Ser Asp Ile Pro Ala Pro Arg Ile Arg Arg 
                725                 730                 735     


Ile Ser Asp Arg Thr Asn Tyr Gly Glu Glu Gly Ser Ala Tyr Ser Leu 
            740                 745                 750         


Leu Tyr Pro Thr Ile Phe Ala Arg Lys Gly Val Phe Glu Arg Asp Phe 
        755                 760                 765             


Phe Lys Thr Arg Ser Lys Glu Glu Ile Ala Glu Ile Leu Cys Asn Ile 
    770                 775                 780                 


Gly Val Lys Leu Ser Asp Glu Glu Phe Glu Asn Val Trp Asn Leu Ala 
785                 790                 795                 800 


Ser Lys Lys His His Arg Gly Glu Val Cys Val Glu Asn Ile Arg Asn 
                805                 810                 815     


Val Leu Asp Glu Leu Arg His Ala Asp Arg Ile Lys Cys Lys Thr Leu 
            820                 825                 830         


Met 
    


<210>  3406
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFHC1__Homo_sapiens__NP_001165891

<400>  3406

Met Leu Lys Thr Ala Phe His Arg Ser Gln Thr Leu Ser Tyr Arg Asn 
1               5                   10                  15      


Gly Tyr Ala Ile Val Arg Arg Pro Thr Val Gly Ile Gly Gly Asp Arg 
            20                  25                  30          


Leu Gln Phe Asn Gln Leu Ser Gln Ala Glu Leu Asp Glu Leu Ala Ser 
        35                  40                  45              


Lys Ala Pro Val Leu Thr Tyr Gly Gln Pro Lys Gln Ala Pro Pro Ala 
    50                  55                  60                  


Asp Phe Ile Pro Ala His Val Ala Phe Asp Lys Lys Val Leu Lys Phe 
65                  70                  75                  80  


Asp Ala Tyr Phe Gln Glu Asp Val Pro Met Ser Thr Glu Glu Gln Tyr 
                85                  90                  95      


Arg Ile Arg Gln Val Asn Ile Tyr Tyr Tyr Leu Glu Asp Asp Ser Met 
            100                 105                 110         


Ser Val Ile Glu Pro Val Val Glu Asn Ser Gly Ile Leu Gln Gly Lys 
        115                 120                 125             


Leu Ile Lys Arg Gln Arg Leu Ala Lys Asn Asp Arg Gly Asp His Tyr 
    130                 135                 140                 


His Trp Lys Asp Leu Asn Arg Gly Ile Asn Ile Thr Ile Tyr Gly Lys 
145                 150                 155                 160 


Thr Phe Arg Val Val Asp Cys Asp Gln Phe Thr Gln Val Phe Leu Glu 
                165                 170                 175     


Ser Gln Gly Ile Glu Leu Asn Pro Pro Glu Lys Met Ala Leu Asp Pro 
            180                 185                 190         


Tyr Thr Glu Leu Arg Lys Gln Pro Leu Arg Lys Tyr Val Thr Pro Ser 
        195                 200                 205             


Asp Phe Asp Gln Leu Lys Gln Phe Leu Thr Phe Asp Lys Gln Val Leu 
    210                 215                 220                 


Arg Phe Tyr Ala Ile Trp Asp Asp Thr Asp Ser Met Tyr Gly Glu Cys 
225                 230                 235                 240 


Arg Thr Tyr Ile Ile His Tyr Tyr Leu Met Asp Asp Thr Val Glu Ile 
                245                 250                 255     


Arg Glu Val His Glu Arg Asn Asp Gly Arg Asp Pro Phe Pro Leu Leu 
            260                 265                 270         


Met Asn Arg Gln Arg Val Pro Lys Val Leu Val Glu Asn Ala Lys Asn 
        275                 280                 285             


Phe Pro Gln Cys Val Leu Glu Ile Ser Asp Gln Glu Val Leu Glu Trp 
    290                 295                 300                 


Tyr Thr Ala Lys Asp Phe Ile Val Gly Lys Ser Leu Thr Ile Leu Gly 
305                 310                 315                 320 


Arg Thr Phe Phe Ile Tyr Asp Cys Asp Pro Phe Thr Arg Arg Tyr Tyr 
                325                 330                 335     


Lys Glu Lys Phe Gly Ile Thr Asp Leu Pro Arg Ile Asp Val Ser Lys 
            340                 345                 350         


Arg Glu Pro Pro Pro Val Lys Gln Glu Leu Pro Pro Tyr Asn Gly Phe 
        355                 360                 365             


Gly Leu Val Glu Asp Ser Ala Gln Asn Cys Phe Ala Leu Ile Pro Lys 
    370                 375                 380                 


Ala Pro Lys Lys Asp Val Ile Lys Met Leu Val Asn Asp Asn Lys Val 
385                 390                 395                 400 


Leu Arg Tyr Leu Ala Val Leu Glu Ser Pro Ile Pro Glu Asp Lys Asp 
                405                 410                 415     


Arg Arg Phe Val Phe Ser Tyr Phe Leu Ala Thr Asp Met Ile Ser Ile 
            420                 425                 430         


Phe Glu Pro Pro Val Arg Asn Ser Gly Ile Ile Gly Gly Lys Tyr Leu 
        435                 440                 445             


Gly Arg Thr Lys Val Val Lys Pro Tyr Ser Thr Val Asp Asn Pro Val 
    450                 455                 460                 


Tyr Tyr Gly Pro Ser Asp Phe Phe Ile Gly Ala Val Ile Glu Val Phe 
465                 470                 475                 480 


Gly His Arg Phe Ile Ile Leu Asp Thr Asp Glu Tyr Val Leu Lys Tyr 
                485                 490                 495     


Met Glu Ser Asn Ala Ala Gln Tyr Ser Pro Glu Ala Leu Ala Ser Ile 
            500                 505                 510         


Gln Asn His Val Arg Lys Arg Glu Ala Pro Ala Pro Glu Ala Glu Ser 
        515                 520                 525             


Lys Gln Thr Glu Lys Asp Pro Gly Val Gln Glu Leu Glu Ala Leu Ile 
    530                 535                 540                 


Asp Thr Ile Gln Lys Gln Leu Lys Asp His Ser Cys Lys Asp Asn Ile 
545                 550                 555                 560 


Arg Glu Ala Phe Gln Ile Tyr Asp Lys Glu Ala Ser Gly Tyr Val Asp 
                565                 570                 575     


Arg Asp Met Phe Phe Lys Ile Cys Glu Ser Leu Asn Val Pro Val Asp 
            580                 585                 590         


Asp Ser Leu Val Lys Glu Leu Ile Arg Met Cys Ser His Gly Glu Gly 
        595                 600                 605             


Lys Ile Asn Tyr Tyr Asn Phe Val Arg Ala Phe Ser Asn 
    610                 615                 620     


<210>  3407
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFHC2__Homo_sapiens__NP_079460

<400>  3407

Met Ala Leu Pro Leu Leu Pro Gly Asn Ser Phe Asn Arg Asn Val Gly 
1               5                   10                  15      


Lys Glu Lys Phe His Lys Ser Gln His Trp Gly Phe Cys Asn Asn Val 
            20                  25                  30          


Met Met Leu Val Ser Asp Glu Lys Pro Gly Ile Gly Gly Glu Pro Leu 
        35                  40                  45              


Leu Gly Gln Lys Ile Lys Pro Lys Cys Ser Ile Tyr Pro Lys Gly Asp 
    50                  55                  60                  


Gly Ser Asp Val Pro Ser Trp Val Ala Phe Asp Lys Gln Val Leu Ser 
65                  70                  75                  80  


Phe Asp Ala Tyr Leu Glu Glu Glu Val Leu Asp Lys Ser Gln Thr Asn 
                85                  90                  95      


Tyr Arg Ile Arg Tyr Tyr Lys Ile Tyr Phe Tyr Pro Glu Asp Asp Thr 
            100                 105                 110         


Ile Gln Val Asn Glu Pro Glu Val Lys Asn Ser Gly Leu Leu Gln Gly 
        115                 120                 125             


Thr Ser Ile Arg Arg His Arg Ile Thr Leu Pro Pro Pro Asp Glu Asp 
    130                 135                 140                 


Gln Phe Tyr Thr Val Tyr His Phe Asn Val Gly Thr Glu Val Val Phe 
145                 150                 155                 160 


Tyr Gly Arg Thr Phe Lys Ile Tyr Asp Cys Asp Ala Phe Thr Arg Asn 
                165                 170                 175     


Phe Leu Arg Lys Ile Gly Val Lys Val Asn Pro Pro Val Gln Cys Pro 
            180                 185                 190         


Glu Asp Pro Tyr Met Lys Ile Arg Arg Glu Val Val Glu His Val Glu 
        195                 200                 205             


Pro Leu Arg Pro Tyr Glu Ser Leu Asp Thr Leu Lys Gln Phe Leu Gln 
    210                 215                 220                 


Tyr His Gly Lys Ile Leu Cys Phe Phe Cys Leu Trp Asp Asp Ser Val 
225                 230                 235                 240 


Ser Met Phe Gly Asp Arg Arg Glu Leu Ile Leu His Tyr Phe Leu Cys 
                245                 250                 255     


Asp Asp Thr Ile Glu Ile Lys Glu Leu Leu Pro His Ser Ser Gly Arg 
            260                 265                 270         


Asp Ala Leu Lys Met Phe Leu Arg Arg Ser Lys Leu Pro Lys Asn Cys 
        275                 280                 285             


Pro Pro Arg Val Tyr Gln Pro Gly Gln Ile Thr Asp Arg Ala Val Leu 
    290                 295                 300                 


Asn Ser Tyr Gly Asp Phe Ile Lys Asn Gln Ala Asp Gly Tyr Leu Phe 
305                 310                 315                 320 


Asp Arg Tyr Lys Leu Gly Lys Val Asp Gln Glu Phe Tyr Lys Asp Ser 
                325                 330                 335     


Asp Leu Ser Leu Gly Val Thr Ile Asn Val Trp Gly Arg Lys Val Leu 
            340                 345                 350         


Leu Tyr Asp Cys Asp Glu Phe Thr Lys Ser Tyr Tyr Lys Ser Lys Tyr 
        355                 360                 365             


Gly Ile Glu Asn Phe Thr Ser Val Ser Cys Lys Pro Pro Ser Pro Pro 
    370                 375                 380                 


Pro Lys Ile Glu Arg Lys Phe Pro Pro Tyr Asn Gly Phe Gly Ser Glu 
385                 390                 395                 400 


Glu Asp Ser Leu Arg Asn Cys Ile Asp Leu Lys Pro Thr Pro His Arg 
                405                 410                 415     


Arg Asn Phe Lys Lys Phe Met Glu Lys Asp Ser Tyr Gly Ser Lys Ser 
            420                 425                 430         


Asn Ile Leu Arg Phe Phe Ala Lys Leu Val Thr Asp Lys Cys Val Asp 
        435                 440                 445             


Leu Asp Arg Met Phe Val Ile Ser Tyr Tyr Leu Gly Asp Asp Thr Ile 
    450                 455                 460                 


Ser Val Phe Glu Pro Ile Glu Arg Asn Ser Gly Ile Ala Gly Gly Met 
465                 470                 475                 480 


Phe Leu Lys Arg Ser Arg Val Lys Lys Pro Gly Gln Glu Val Phe Lys 
                485                 490                 495     


Ser Glu Leu Ser Glu Tyr Ile Lys Ala Glu Glu Leu Tyr Ile Gly Val 
            500                 505                 510         


Thr Val Asn Val Asn Gly Tyr Leu Phe Arg Leu Leu Asn Ala Asp Glu 
        515                 520                 525             


Tyr Thr Leu Asn Tyr Met Glu Gln Asn Thr Asp Lys Tyr Pro Phe Ser 
    530                 535                 540                 


Asn Leu Lys Leu Ala Leu Gln Lys Leu Lys Gln Glu Glu Gly Lys Ser 
545                 550                 555                 560 


Arg Glu Leu Lys Gln Val Phe Lys Ala Ala Asp Ser Lys His Thr Asn 
                565                 570                 575     


Met Val Asp Tyr Asn Thr Phe Arg Asp Ile Leu Met Ser Leu Thr Val 
            580                 585                 590         


Gly Asn Leu Ala Glu Gln Glu Phe Val Thr Ile Ala Arg His Tyr Arg 
        595                 600                 605             


Val Pro Glu Gly Thr Cys Ser Asp Met Asp Phe Leu Ile Ala Leu Ala 
    610                 615                 620                 


His Glu Lys Phe Lys Lys Asn Met Phe Glu Asn Phe Asp Thr Phe Ile 
625                 630                 635                 640 


Tyr Ser Cys Val Tyr Glu Asp Arg Glu Lys Lys Asn Val Leu Pro Thr 
                645                 650                 655     


Lys Asp Ile Lys Arg Leu Cys Lys Ser Ser Arg Leu Pro Leu Ser Asp 
            660                 665                 670         


Asp Leu Leu Glu Ser Leu Leu Ser Arg Phe Glu Asp Ser Glu Lys Gln 
        675                 680                 685             


Ile Asp Tyr Lys Ser Phe Phe Ser Ala Leu Asn Trp Arg Lys Asn Pro 
    690                 695                 700                 


Val Pro Glu Leu Gln Pro Ala Ser Tyr Leu Lys Glu Arg Cys Glu Asp 
705                 710                 715                 720 


Val Trp Leu Gly Met Pro Ser Pro Ile Pro Ala Lys Tyr Ile Asp Tyr 
                725                 730                 735     


Trp Thr Phe Leu Lys Asp Ala Phe Gly Leu Glu Glu Glu 
            740                 745                 


<210>  3408
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFHD1__Homo_sapiens__NP_001230181

<400>  3408

Met Gly Glu Leu Gln Tyr Asp Ala Gly Arg Asp Gly Phe Ile Asp Leu 
1               5                   10                  15      


Met Glu Leu Lys Leu Met Met Glu Lys Leu Gly Ala Pro Gln Thr His 
            20                  25                  30          


Leu Gly Leu Lys Ser Met Ile Lys Glu Val Asp Glu Asp Phe Asp Gly 
        35                  40                  45              


Lys Leu Ser Phe Arg Glu Phe Leu Leu Ile Phe His Lys Ala Ala Ala 
    50                  55                  60                  


Gly Glu Leu Gln Glu Asp Ser Gly Leu Met Ala Leu Ala Lys Leu Ser 
65                  70                  75                  80  


Glu Ile Asp Val Ala Leu Glu Gly Val Lys Gly Ala Lys Asn Phe Phe 
                85                  90                  95      


Glu Ala Lys Val Gln Ala Leu Ser Ser Ala Ser Lys Phe Glu Ala Glu 
            100                 105                 110         


Leu Lys Ala Glu Gln Asp Glu Arg Lys Arg Glu Glu Glu Glu Arg Arg 
        115                 120                 125             


Leu Arg Gln Ala Ala Phe Gln Lys Leu Lys Ala Asn Phe Asn Thr 
    130                 135                 140             


<210>  3409
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNA1__Homo_sapiens__NP_004419

<400>  3409

Met Glu Phe Leu Trp Ala Pro Leu Leu Gly Leu Cys Cys Ser Leu Ala 
1               5                   10                  15      


Ala Ala Asp Arg His Thr Val Phe Trp Asn Ser Ser Asn Pro Lys Phe 
            20                  25                  30          


Arg Asn Glu Asp Tyr Thr Ile His Val Gln Leu Asn Asp Tyr Val Asp 
        35                  40                  45              


Ile Ile Cys Pro His Tyr Glu Asp His Ser Val Ala Asp Ala Ala Met 
    50                  55                  60                  


Glu Gln Tyr Ile Leu Tyr Leu Val Glu His Glu Glu Tyr Gln Leu Cys 
65                  70                  75                  80  


Gln Pro Gln Ser Lys Asp Gln Val Arg Trp Gln Cys Asn Arg Pro Ser 
                85                  90                  95      


Ala Lys His Gly Pro Glu Lys Leu Ser Glu Lys Phe Gln Arg Phe Thr 
            100                 105                 110         


Pro Phe Thr Leu Gly Lys Glu Phe Lys Glu Gly His Ser Tyr Tyr Tyr 
        115                 120                 125             


Ile Ser Lys Pro Ile His Gln His Glu Asp Arg Cys Leu Arg Leu Lys 
    130                 135                 140                 


Val Thr Val Ser Gly Lys Ile Thr His Ser Pro Gln Ala His Asp Asn 
145                 150                 155                 160 


Pro Gln Glu Lys Arg Leu Ala Ala Asp Asp Pro Glu Val Arg Val Leu 
                165                 170                 175     


His Ser Ile Gly His Ser Ala Ala Pro Arg Leu Phe Pro Leu Ala Trp 
            180                 185                 190         


Thr Val Leu Leu Leu Pro Leu Leu Leu Leu Gln Thr Pro 
        195                 200                 205 


<210>  3410
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNA2__Homo_sapiens__NP_001396

<400>  3410

Met Ala Pro Ala Gln Arg Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Pro Pro Pro Pro Phe Ala Arg Ala Glu Asp Ala Ala Arg Ala 
            20                  25                  30          


Asn Ser Asp Arg Tyr Ala Val Tyr Trp Asn Arg Ser Asn Pro Arg Phe 
        35                  40                  45              


His Ala Gly Ala Gly Asp Asp Gly Gly Gly Tyr Thr Val Glu Val Ser 
    50                  55                  60                  


Ile Asn Asp Tyr Leu Asp Ile Tyr Cys Pro His Tyr Gly Ala Pro Leu 
65                  70                  75                  80  


Pro Pro Ala Glu Arg Met Glu His Tyr Val Leu Tyr Met Val Asn Gly 
                85                  90                  95      


Glu Gly His Ala Ser Cys Asp His Arg Gln Arg Gly Phe Lys Arg Trp 
            100                 105                 110         


Glu Cys Asn Arg Pro Ala Ala Pro Gly Gly Pro Leu Lys Phe Ser Glu 
        115                 120                 125             


Lys Phe Gln Leu Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Arg Pro 
    130                 135                 140                 


Gly His Glu Tyr Tyr Tyr Ile Ser Ala Thr Pro Pro Asn Ala Val Asp 
145                 150                 155                 160 


Arg Pro Cys Leu Arg Leu Lys Val Tyr Val Arg Pro Thr Asn Glu Thr 
                165                 170                 175     


Leu Tyr Glu Ala Pro Glu Pro Ile Phe Thr Ser Asn Asn Ser Cys Ser 
            180                 185                 190         


Ser Pro Gly Gly Cys Arg Leu Phe Leu Ser Thr Ile Pro Val Leu Trp 
        195                 200                 205             


Thr Leu Leu Gly Ser 
    210             


<210>  3411
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNA3__Homo_sapiens__NP_004943

<400>  3411

Met Ala Ala Ala Pro Leu Leu Leu Leu Leu Leu Leu Val Pro Val Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Ala Gln Gly Pro Gly Gly Ala Leu Gly Asn Arg 
            20                  25                  30          


His Ala Val Tyr Trp Asn Ser Ser Asn Gln His Leu Arg Arg Glu Gly 
        35                  40                  45              


Tyr Thr Val Gln Val Asn Val Asn Asp Tyr Leu Asp Ile Tyr Cys Pro 
    50                  55                  60                  


His Tyr Asn Ser Ser Gly Val Gly Pro Gly Ala Gly Pro Gly Pro Gly 
65                  70                  75                  80  


Gly Gly Ala Glu Gln Tyr Val Leu Tyr Met Val Ser Arg Asn Gly Tyr 
                85                  90                  95      


Arg Thr Cys Asn Ala Ser Gln Gly Phe Lys Arg Trp Glu Cys Asn Arg 
            100                 105                 110         


Pro His Ala Pro His Ser Pro Ile Lys Phe Ser Glu Lys Phe Gln Arg 
        115                 120                 125             


Tyr Ser Ala Phe Ser Leu Gly Tyr Glu Phe His Ala Gly His Glu Tyr 
    130                 135                 140                 


Tyr Tyr Ile Ser Thr Pro Thr His Asn Leu His Trp Lys Cys Leu Arg 
145                 150                 155                 160 


Met Lys Val Phe Val Cys Cys Ala Ser Thr Ser His Ser Gly Glu Lys 
                165                 170                 175     


Pro Val Pro Thr Leu Pro Gln Phe Thr Met Gly Pro Asn Val Lys Ile 
            180                 185                 190         


Asn Val Leu Glu Asp Phe Glu Gly Glu Asn Pro Gln Val Pro Lys Leu 
        195                 200                 205             


Glu Lys Ser Ile Ser Gly Thr Ser Pro Lys Arg Glu His Leu Pro Leu 
    210                 215                 220                 


Ala Val Gly Ile Ala Phe Phe Leu Met Thr Phe Leu Ala Ser 
225                 230                 235             


<210>  3412
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNA4__Homo_sapiens__NP_005218

<400>  3412

Met Arg Leu Leu Pro Leu Leu Arg Thr Val Leu Trp Ala Ala Phe Leu 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Gly Ser Ser Leu Arg His Val Val Tyr Trp 
            20                  25                  30          


Asn Ser Ser Asn Pro Arg Leu Leu Arg Gly Asp Ala Val Val Glu Leu 
        35                  40                  45              


Gly Leu Asn Asp Tyr Leu Asp Ile Val Cys Pro His Tyr Glu Gly Pro 
    50                  55                  60                  


Gly Pro Pro Glu Gly Pro Glu Thr Phe Ala Leu Tyr Met Val Asp Trp 
65                  70                  75                  80  


Pro Gly Tyr Glu Ser Cys Gln Ala Glu Gly Pro Arg Ala Tyr Lys Arg 
                85                  90                  95      


Trp Val Cys Ser Leu Pro Phe Gly His Val Gln Phe Ser Glu Lys Ile 
            100                 105                 110         


Gln Arg Phe Thr Pro Phe Ser Leu Gly Phe Glu Phe Leu Pro Gly Glu 
        115                 120                 125             


Thr Tyr Tyr Tyr Ile Ser Val Pro Thr Pro Glu Ser Ser Gly Gln Cys 
    130                 135                 140                 


Leu Arg Leu Gln Val Ser Val Cys Cys Lys Glu Arg Lys Ser Glu Ser 
145                 150                 155                 160 


Ala His Pro Val Gly Ser Pro Gly Glu Ser Gly Thr Ser Gly Trp Arg 
                165                 170                 175     


Gly Gly Asp Thr Pro Ser Pro Leu Cys Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Leu Ile Leu Arg Leu Leu Arg Ile Leu 
        195                 200     


<210>  3413
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNA5__Homo_sapiens__NP_001953

<400>  3413

Met Leu His Val Glu Met Leu Thr Leu Val Phe Leu Val Leu Trp Met 
1               5                   10                  15      


Cys Val Phe Ser Gln Asp Pro Gly Ser Lys Ala Val Ala Asp Arg Tyr 
            20                  25                  30          


Ala Val Tyr Trp Asn Ser Ser Asn Pro Arg Phe Gln Arg Gly Asp Tyr 
        35                  40                  45              


His Ile Asp Val Cys Ile Asn Asp Tyr Leu Asp Val Phe Cys Pro His 
    50                  55                  60                  


Tyr Glu Asp Ser Val Pro Glu Asp Lys Thr Glu Arg Tyr Val Leu Tyr 
65                  70                  75                  80  


Met Val Asn Phe Asp Gly Tyr Ser Ala Cys Asp His Thr Ser Lys Gly 
                85                  90                  95      


Phe Lys Arg Trp Glu Cys Asn Arg Pro His Ser Pro Asn Gly Pro Leu 
            100                 105                 110         


Lys Phe Ser Glu Lys Phe Gln Leu Phe Thr Pro Phe Ser Leu Gly Phe 
        115                 120                 125             


Glu Phe Arg Pro Gly Arg Glu Tyr Phe Tyr Ile Ser Ser Ala Ile Pro 
    130                 135                 140                 


Asp Asn Gly Arg Arg Ser Cys Leu Lys Leu Lys Val Phe Val Arg Pro 
145                 150                 155                 160 


Thr Asn Ser Cys Met Lys Thr Ile Gly Val His Asp Arg Val Phe Asp 
                165                 170                 175     


Val Asn Asp Lys Val Glu Asn Ser Leu Glu Pro Ala Asp Asp Thr Val 
            180                 185                 190         


His Glu Ser Ala Glu Pro Ser Arg Gly Glu Asn Ala Ala Gln Thr Pro 
        195                 200                 205             


Arg Ile Pro Ser Arg Leu Leu Ala Ile Leu Leu Phe Leu Leu Ala Met 
    210                 215                 220                 


Leu Leu Thr Leu 
225             


<210>  3414
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNB1__Homo_sapiens__NP_004420

<400>  3414

Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met 
1               5                   10                  15      


Val Val Trp Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu 
            20                  25                  30          


Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys 
        35                  40                  45              


Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys 
    50                  55                  60                  


Pro Arg Ala Glu Ala Gly Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu 
65                  70                  75                  80  


Val Arg Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn 
                85                  90                  95      


Val Leu Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile 
            100                 105                 110         


Lys Phe Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys 
        115                 120                 125             


His His Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu Gly 
    130                 135                 140                 


Leu Glu Asn Arg Glu Gly Gly Val Cys Arg Thr Arg Thr Met Lys Ile 
145                 150                 155                 160 


Ile Met Lys Val Gly Gln Asp Pro Asn Ala Val Thr Pro Glu Gln Leu 
                165                 170                 175     


Thr Thr Ser Arg Pro Ser Lys Glu Ala Asp Asn Thr Val Lys Met Ala 
            180                 185                 190         


Thr Gln Ala Pro Gly Ser Arg Gly Ser Leu Gly Asp Ser Asp Gly Lys 
        195                 200                 205             


His Glu Thr Val Asn Gln Glu Glu Lys Ser Gly Pro Gly Ala Ser Gly 
    210                 215                 220                 


Gly Ser Ser Gly Asp Pro Asp Gly Phe Phe Asn Ser Lys Val Ala Leu 
225                 230                 235                 240 


Phe Ala Ala Val Gly Ala Gly Cys Val Ile Phe Leu Leu Ile Ile Ile 
                245                 250                 255     


Phe Leu Thr Val Leu Leu Leu Lys Leu Arg Lys Arg His Arg Lys His 
            260                 265                 270         


Thr Gln Gln Arg Ala Ala Ala Leu Ser Leu Ser Thr Leu Ala Ser Pro 
        275                 280                 285             


Lys Gly Gly Ser Gly Thr Ala Gly Thr Glu Pro Ser Asp Ile Ile Ile 
    290                 295                 300                 


Pro Leu Arg Thr Thr Glu Asn Asn Tyr Cys Pro His Tyr Glu Lys Val 
305                 310                 315                 320 


Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu Met Pro Pro 
                325                 330                 335     


Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val 
            340                 345     


<210>  3415
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNB2__Homo_sapiens__NP_004084

<400>  3415

Met Ala Val Arg Arg Asp Ser Val Trp Lys Tyr Cys Trp Gly Val Leu 
1               5                   10                  15      


Met Val Leu Cys Arg Thr Ala Ile Ser Lys Ser Ile Val Leu Glu Pro 
            20                  25                  30          


Ile Tyr Trp Asn Ser Ser Asn Ser Lys Phe Leu Pro Gly Gln Gly Leu 
        35                  40                  45              


Val Leu Tyr Pro Gln Ile Gly Asp Lys Leu Asp Ile Ile Cys Pro Lys 
    50                  55                  60                  


Val Asp Ser Lys Thr Val Gly Gln Tyr Glu Tyr Tyr Lys Val Tyr Met 
65                  70                  75                  80  


Val Asp Lys Asp Gln Ala Asp Arg Cys Thr Ile Lys Lys Glu Asn Thr 
                85                  90                  95      


Pro Leu Leu Asn Cys Ala Lys Pro Asp Gln Asp Ile Lys Phe Thr Ile 
            100                 105                 110         


Lys Phe Gln Glu Phe Ser Pro Asn Leu Trp Gly Leu Glu Phe Gln Lys 
        115                 120                 125             


Asn Lys Asp Tyr Tyr Ile Ile Ser Thr Ser Asn Gly Ser Leu Glu Gly 
    130                 135                 140                 


Leu Asp Asn Gln Glu Gly Gly Val Cys Gln Thr Arg Ala Met Lys Ile 
145                 150                 155                 160 


Leu Met Lys Val Gly Gln Asp Ala Ser Ser Ala Gly Ser Thr Arg Asn 
                165                 170                 175     


Lys Asp Pro Thr Arg Arg Pro Glu Leu Glu Ala Gly Thr Asn Gly Arg 
            180                 185                 190         


Ser Ser Thr Thr Ser Pro Phe Val Lys Pro Asn Pro Gly Ser Ser Thr 
        195                 200                 205             


Asp Gly Asn Ser Ala Gly His Ser Gly Asn Asn Ile Leu Gly Ser Glu 
    210                 215                 220                 


Val Ala Leu Phe Ala Gly Ile Ala Ser Gly Cys Ile Ile Phe Ile Val 
225                 230                 235                 240 


Ile Ile Ile Thr Leu Val Val Leu Leu Leu Lys Tyr Arg Arg Arg His 
                245                 250                 255     


Arg Lys His Ser Pro Gln His Thr Thr Thr Leu Ser Leu Ser Thr Leu 
            260                 265                 270         


Ala Thr Pro Lys Arg Ser Gly Asn Asn Asn Gly Ser Glu Pro Ser Asp 
        275                 280                 285             


Ile Ile Ile Pro Leu Arg Thr Ala Asp Ser Val Phe Cys Pro His Tyr 
    290                 295                 300                 


Glu Lys Val Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu 
305                 310                 315                 320 


Met Pro Pro Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val 
                325                 330             


<210>  3416
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFNB3__Homo_sapiens__NP_001397

<400>  3416

Met Gly Pro Pro His Ser Gly Pro Gly Gly Val Arg Val Gly Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Val Leu Gly Leu Val Ser Gly Leu Ser Leu Glu Pro 
            20                  25                  30          


Val Tyr Trp Asn Ser Ala Asn Lys Arg Phe Gln Ala Glu Gly Gly Tyr 
        35                  40                  45              


Val Leu Tyr Pro Gln Ile Gly Asp Arg Leu Asp Leu Leu Cys Pro Arg 
    50                  55                  60                  


Ala Arg Pro Pro Gly Pro His Ser Ser Pro Asn Tyr Glu Phe Tyr Lys 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Gly Ala Gln Gly Arg Arg Cys Glu Ala Pro Pro 
                85                  90                  95      


Ala Pro Asn Leu Leu Leu Thr Cys Asp Arg Pro Asp Leu Asp Leu Arg 
            100                 105                 110         


Phe Thr Ile Lys Phe Gln Glu Tyr Ser Pro Asn Leu Trp Gly His Glu 
        115                 120                 125             


Phe Arg Ser His His Asp Tyr Tyr Ile Ile Ala Thr Ser Asp Gly Thr 
    130                 135                 140                 


Arg Glu Gly Leu Glu Ser Leu Gln Gly Gly Val Cys Leu Thr Arg Gly 
145                 150                 155                 160 


Met Lys Val Leu Leu Arg Val Gly Gln Ser Pro Arg Gly Gly Ala Val 
                165                 170                 175     


Pro Arg Lys Pro Val Ser Glu Met Pro Met Glu Arg Asp Arg Gly Ala 
            180                 185                 190         


Ala His Ser Leu Glu Pro Gly Lys Glu Asn Leu Pro Gly Asp Pro Thr 
        195                 200                 205             


Ser Asn Ala Thr Ser Arg Gly Ala Glu Gly Pro Leu Pro Pro Pro Ser 
    210                 215                 220                 


Met Pro Ala Val Ala Gly Ala Ala Gly Gly Leu Ala Leu Leu Leu Leu 
225                 230                 235                 240 


Gly Val Ala Gly Ala Gly Gly Ala Met Cys Trp Arg Arg Arg Arg Ala 
                245                 250                 255     


Lys Pro Ser Glu Ser Arg His Pro Gly Pro Gly Ser Phe Gly Arg Gly 
            260                 265                 270         


Gly Ser Leu Gly Leu Gly Gly Gly Gly Gly Met Gly Pro Arg Glu Ala 
        275                 280                 285             


Glu Pro Gly Glu Leu Gly Ile Ala Leu Arg Gly Gly Gly Ala Ala Asp 
    290                 295                 300                 


Pro Pro Phe Cys Pro His Tyr Glu Lys Val Ser Gly Asp Tyr Gly His 
305                 310                 315                 320 


Pro Val Tyr Ile Val Gln Asp Gly Pro Pro Gln Ser Pro Pro Asn Ile 
                325                 330                 335     


Tyr Tyr Lys Val 
            340 


<210>  3417
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFR3A__Homo_sapiens__NP_055952

<400>  3417

Met Pro Thr Arg Val Cys Cys Cys Cys Ser Ala Leu Arg Pro Arg Tyr 
1               5                   10                  15      


Lys Arg Leu Val Asp Asn Ile Phe Pro Glu Asp Pro Lys Asp Gly Leu 
            20                  25                  30          


Val Lys Thr Asp Met Glu Lys Leu Thr Phe Tyr Ala Val Ser Ala Pro 
        35                  40                  45              


Glu Lys Leu Asp Arg Ile Gly Ser Tyr Leu Ala Glu Arg Leu Ser Arg 
    50                  55                  60                  


Asp Val Val Arg His Arg Ser Gly Tyr Val Leu Ile Ala Met Glu Ala 
65                  70                  75                  80  


Leu Asp Gln Leu Leu Met Ala Cys His Ser Gln Ser Ile Lys Pro Phe 
                85                  90                  95      


Val Glu Ser Phe Leu His Met Val Ala Lys Leu Leu Glu Ser Gly Glu 
            100                 105                 110         


Pro Lys Leu Gln Val Leu Gly Thr Asn Ser Phe Val Lys Phe Ala Asn 
        115                 120                 125             


Ile Glu Glu Asp Thr Pro Ser Tyr His Arg Arg Tyr Asp Phe Phe Val 
    130                 135                 140                 


Ser Arg Phe Ser Ala Met Cys His Ser Cys His Ser Asp Pro Glu Ile 
145                 150                 155                 160 


Arg Thr Glu Ile Arg Ile Ala Gly Ile Arg Gly Ile Gln Gly Val Val 
                165                 170                 175     


Arg Lys Thr Val Asn Asp Glu Leu Arg Ala Thr Ile Trp Glu Pro Gln 
            180                 185                 190         


His Met Asp Lys Ile Val Pro Ser Leu Leu Phe Asn Met Gln Lys Ile 
        195                 200                 205             


Glu Glu Val Asp Ser Arg Ile Gly Pro Pro Ser Ser Pro Ser Ala Thr 
    210                 215                 220                 


Asp Lys Glu Glu Asn Pro Ala Val Leu Ala Glu Asn Cys Phe Arg Glu 
225                 230                 235                 240 


Leu Leu Gly Arg Ala Thr Phe Gly Asn Met Asn Asn Ala Val Arg Pro 
                245                 250                 255     


Val Phe Ala His Leu Asp His His Lys Leu Trp Asp Pro Asn Glu Phe 
            260                 265                 270         


Ala Val His Cys Phe Lys Ile Ile Met Tyr Ser Ile Gln Ala Gln Tyr 
        275                 280                 285             


Ser His His Val Ile Gln Glu Ile Leu Gly His Leu Asp Ala Arg Lys 
    290                 295                 300                 


Lys Asp Ala Pro Arg Val Arg Ala Gly Ile Ile Gln Val Leu Leu Glu 
305                 310                 315                 320 


Ala Val Ala Ile Ala Ala Lys Gly Ser Ile Gly Pro Thr Val Leu Glu 
                325                 330                 335     


Val Phe Asn Thr Leu Leu Lys His Leu Arg Leu Ser Val Glu Phe Glu 
            340                 345                 350         


Ala Asn Asp Leu Gln Gly Gly Ser Val Gly Ser Val Asn Leu Asn Thr 
        355                 360                 365             


Ser Ser Lys Asp Asn Asp Glu Lys Ile Val Gln Asn Ala Ile Ile Gln 
    370                 375                 380                 


Thr Ile Gly Phe Phe Gly Ser Asn Leu Pro Asp Tyr Gln Arg Ser Glu 
385                 390                 395                 400 


Ile Met Met Phe Ile Met Gly Lys Val Pro Val Phe Gly Thr Ser Thr 
                405                 410                 415     


His Thr Leu Asp Ile Ser Gln Leu Gly Asp Leu Gly Thr Arg Arg Ile 
            420                 425                 430         


Gln Ile Met Leu Leu Arg Ser Leu Leu Met Val Thr Ser Gly Tyr Lys 
        435                 440                 445             


Ala Lys Thr Ile Val Thr Ala Leu Pro Gly Ser Phe Leu Asp Pro Leu 
    450                 455                 460                 


Leu Ser Pro Ser Leu Met Glu Asp Tyr Glu Leu Arg Gln Leu Val Leu 
465                 470                 475                 480 


Glu Val Met His Asn Leu Met Asp Arg His Asp Asn Arg Ala Lys Leu 
                485                 490                 495     


Arg Gly Ile Arg Ile Ile Pro Asp Val Ala Asp Leu Lys Ile Lys Arg 
            500                 505                 510         


Glu Lys Ile Cys Arg Gln Asp Thr Ser Phe Met Lys Lys Asn Gly Gln 
        515                 520                 525             


Gln Leu Tyr Arg His Ile Tyr Leu Gly Cys Lys Glu Glu Asp Asn Val 
    530                 535                 540                 


Gln Lys Asn Tyr Glu Leu Leu Tyr Thr Ser Leu Ala Leu Ile Thr Ile 
545                 550                 555                 560 


Glu Leu Ala Asn Glu Glu Val Val Ile Asp Leu Ile Arg Leu Ala Ile 
                565                 570                 575     


Ala Leu Gln Asp Ser Ala Ile Ile Asn Glu Asp Asn Leu Pro Met Phe 
            580                 585                 590         


His Arg Cys Gly Ile Met Ala Leu Val Ala Ala Tyr Leu Asn Phe Val 
        595                 600                 605             


Ser Gln Met Ile Ala Val Pro Ala Phe Cys Gln His Val Ser Lys Val 
    610                 615                 620                 


Ile Glu Ile Arg Thr Met Glu Ala Pro Tyr Phe Leu Pro Glu His Ile 
625                 630                 635                 640 


Phe Arg Asp Lys Cys Met Leu Pro Lys Ser Leu Glu Lys His Glu Lys 
                645                 650                 655     


Asp Leu Tyr Phe Leu Thr Asn Lys Ile Ala Glu Ser Leu Gly Gly Ser 
            660                 665                 670         


Gly Tyr Ser Val Glu Arg Leu Ser Val Pro Tyr Val Pro Gln Val Thr 
        675                 680                 685             


Asp Glu Asp Arg Leu Ser Arg Arg Lys Ser Ile Val Asp Thr Val Ser 
    690                 695                 700                 


Ile Gln Val Asp Ile Leu Ser Asn Asn Val Pro Ser Asp Asp Val Val 
705                 710                 715                 720 


Ser Asn Thr Glu Glu Ile Thr Phe Glu Ala Leu Lys Lys Ala Ile Asp 
                725                 730                 735     


Thr Ser Gly Met Glu Glu Gln Glu Lys Glu Lys Arg Arg Leu Val Ile 
            740                 745                 750         


Glu Lys Phe Gln Lys Ala Pro Phe Glu Glu Ile Ala Ala Gln Cys Glu 
        755                 760                 765             


Ser Lys Ala Asn Leu Leu His Asp Arg Leu Ala Gln Ile Leu Glu Leu 
    770                 775                 780                 


Thr Ile Arg Pro Pro Pro Ser Pro Ser Gly Thr Leu Thr Ile Thr Ser 
785                 790                 795                 800 


Gly His Ala Gln Tyr Gln Ser Val Pro Val Tyr Glu Met Lys Phe Pro 
                805                 810                 815     


Asp Leu Cys Val Tyr 
            820     


<210>  3418
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFR3B__Homo_sapiens__NP_055786

<400>  3418

Met Tyr Gly Val Cys Gly Cys Cys Gly Ala Leu Arg Pro Arg Tyr Lys 
1               5                   10                  15      


Arg Leu Val Asp Asn Ile Phe Pro Glu Asp Pro Glu Asp Gly Leu Val 
            20                  25                  30          


Lys Thr Asn Met Glu Lys Leu Thr Phe Tyr Ala Leu Ser Ala Pro Glu 
        35                  40                  45              


Lys Leu Asp Arg Ile Gly Ala Tyr Leu Ser Glu Arg Leu Ile Arg Asp 
    50                  55                  60                  


Val Gly Arg His Arg Tyr Gly Tyr Val Cys Ile Ala Met Glu Ala Leu 
65                  70                  75                  80  


Asp Gln Leu Leu Met Ala Cys His Cys Gln Ser Ile Asn Leu Phe Val 
                85                  90                  95      


Glu Ser Phe Leu Lys Met Val Ala Lys Leu Leu Glu Ser Glu Lys Pro 
            100                 105                 110         


Asn Leu Gln Ile Leu Gly Thr Asn Ser Phe Val Lys Phe Ala Asn Ile 
        115                 120                 125             


Glu Glu Asp Thr Pro Ser Tyr His Arg Ser Tyr Asp Phe Phe Val Ser 
    130                 135                 140                 


Arg Phe Ser Glu Met Cys His Ser Ser His Asp Asp Leu Glu Ile Lys 
145                 150                 155                 160 


Thr Lys Ile Arg Met Ser Gly Ile Lys Gly Leu Gln Gly Val Val Arg 
                165                 170                 175     


Lys Thr Val Asn Asp Glu Leu Gln Ala Asn Ile Trp Asp Pro Gln His 
            180                 185                 190         


Met Asp Lys Ile Val Pro Ser Leu Leu Phe Asn Leu Gln His Val Glu 
        195                 200                 205             


Glu Ala Glu Ser Arg Ser Pro Ser Pro Leu Gln Ala Pro Glu Lys Glu 
    210                 215                 220                 


Lys Glu Ser Pro Ala Glu Leu Ala Glu Arg Cys Leu Arg Glu Leu Leu 
225                 230                 235                 240 


Gly Arg Ala Ala Phe Gly Asn Ile Lys Asn Ala Ile Lys Pro Val Leu 
                245                 250                 255     


Ile His Leu Asp Asn His Ser Leu Trp Glu Pro Lys Val Phe Ala Ile 
            260                 265                 270         


Arg Cys Phe Lys Ile Ile Met Tyr Ser Ile Gln Pro Gln His Ser His 
        275                 280                 285             


Leu Val Ile Gln Gln Leu Leu Gly His Leu Asp Ala Asn Ser Arg Ser 
    290                 295                 300                 


Ala Ala Thr Val Arg Ala Gly Ile Val Glu Val Leu Ser Glu Ala Ala 
305                 310                 315                 320 


Val Ile Ala Ala Thr Gly Ser Val Gly Pro Thr Val Leu Glu Met Phe 
                325                 330                 335     


Asn Thr Leu Leu Arg Gln Leu Arg Leu Ser Ile Asp Tyr Ala Leu Thr 
            340                 345                 350         


Gly Ser Tyr Asp Gly Ala Val Ser Leu Gly Thr Lys Ile Ile Lys Glu 
        355                 360                 365             


His Glu Glu Arg Met Phe Gln Glu Ala Val Ile Lys Thr Val Gly Ser 
    370                 375                 380                 


Phe Ala Ser Thr Leu Pro Thr Tyr Gln Arg Ser Glu Val Ile Leu Phe 
385                 390                 395                 400 


Ile Met Ser Lys Val Pro Arg Pro Ser Leu His Gln Ala Val Asp Thr 
                405                 410                 415     


Gly Arg Thr Gly Glu Asn Arg Asn Arg Leu Thr Gln Ile Met Leu Leu 
            420                 425                 430         


Lys Ser Leu Leu Gln Val Ser Thr Gly Phe Gln Cys Asn Asn Met Met 
        435                 440                 445             


Ser Ala Leu Pro Ser Asn Phe Leu Asp Arg Leu Leu Ser Thr Ala Leu 
    450                 455                 460                 


Met Glu Asp Ala Glu Ile Arg Leu Phe Val Leu Glu Ile Leu Ile Ser 
465                 470                 475                 480 


Phe Ile Asp Arg His Gly Asn Arg His Lys Phe Ser Thr Ile Ser Thr 
                485                 490                 495     


Leu Ser Asp Ile Ser Val Leu Lys Leu Lys Val Asp Lys Cys Ser Arg 
            500                 505                 510         


Gln Asp Thr Val Phe Met Lys Lys His Ser Gln Gln Leu Tyr Arg His 
        515                 520                 525             


Ile Tyr Leu Ser Cys Lys Glu Glu Thr Asn Val Gln Lys His Tyr Glu 
    530                 535                 540                 


Ala Leu Tyr Gly Leu Leu Ala Leu Ile Ser Ile Glu Leu Ala Asn Glu 
545                 550                 555                 560 


Glu Val Val Val Asp Leu Ile Arg Leu Val Leu Ala Val Gln Asp Val 
                565                 570                 575     


Ala Gln Val Asn Glu Glu Asn Leu Pro Val Tyr Asn Arg Cys Ala Leu 
            580                 585                 590         


Tyr Ala Leu Gly Ala Ala Tyr Leu Asn Leu Ile Ser Gln Leu Thr Thr 
        595                 600                 605             


Val Pro Ala Phe Cys Gln His Ile His Glu Val Ile Glu Thr Arg Lys 
    610                 615                 620                 


Lys Glu Ala Pro Tyr Met Leu Pro Glu Asp Val Phe Val Glu Arg Pro 
625                 630                 635                 640 


Arg Leu Ser Gln Asn Leu Asp Gly Val Val Ile Glu Leu Leu Phe Arg 
                645                 650                 655     


Gln Ser Lys Ile Ser Glu Val Leu Gly Gly Ser Gly Tyr Asn Ser Asp 
            660                 665                 670         


Arg Leu Cys Leu Pro Tyr Ile Pro Gln Leu Thr Asp Glu Asp Arg Leu 
        675                 680                 685             


Ser Lys Arg Arg Ser Ile Gly Glu Thr Ile Ser Leu Gln Val Glu Val 
    690                 695                 700                 


Glu Ser Arg Asn Ser Pro Glu Lys Glu Glu Arg Val Pro Ala Glu Glu 
705                 710                 715                 720 


Ile Thr Tyr Glu Thr Leu Lys Lys Ala Ile Val Asp Ser Val Ala Val 
                725                 730                 735     


Glu Glu Gln Glu Arg Glu Arg Arg Arg Gln Val Val Glu Lys Phe Gln 
            740                 745                 750         


Lys Ala Pro Phe Glu Glu Ile Ala Ala His Cys Gly Ala Arg Ala Ser 
        755                 760                 765             


Leu Leu Gln Ser Lys Leu Asn Gln Ile Phe Glu Ile Thr Ile Arg Pro 
    770                 775                 780                 


Pro Pro Ser Pro Ser Gly Thr Ile Thr Ala Ala Tyr Gly Gln Pro Gln 
785                 790                 795                 800 


Asn His Ser Ile Pro Val Tyr Glu Met Lys Phe Pro Asp Leu Cys Val 
                805                 810                 815     


Tyr 
    


<210>  3419
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFS__Homo_sapiens__NP_001264103

<400>  3419

Met Ala Ile Ala Thr Ser Val Tyr Val Val Pro Pro Pro Ala Arg Pro 
1               5                   10                  15      


Cys Pro Thr Ser Gly Pro Pro Ala Gly Pro Cys Pro Pro Ser Pro Asp 
            20                  25                  30          


Leu Ile Tyr Lys Ile Pro Arg Ala Ser Gly Thr Gln Leu Ala Ala Pro 
        35                  40                  45              


Arg Asp Ala Leu Glu Val Tyr Asp Val Pro Pro Thr Ala Leu Arg Val 
    50                  55                  60                  


Pro Ser Ser Gly Pro Tyr Asp Cys Pro Ala Ser Phe Ser His Pro Leu 
65                  70                  75                  80  


Thr Arg Val Ala Pro Gln Pro Pro Gly Glu Asp Asp Ala Pro Pro Ser 
                85                  90                  95      


Pro Glu Pro Pro Gly Ala Leu Ala Ser His Asp Gln Asp Thr Leu Ala 
            100                 105                 110         


Gln Leu Leu Ala Arg Ser Pro Pro Pro Pro His Arg Pro Arg Leu Pro 
        115                 120                 125             


Ser Ala Glu Ser Leu Ser Arg Arg Pro Leu Pro Ala Leu Pro Val Pro 
    130                 135                 140                 


Glu Ala Pro Ser Pro Ser Pro Val Pro Ser Pro Ala Pro Gly Arg Lys 
145                 150                 155                 160 


Gly Ser Ile Gln Asp Arg Pro Leu Pro Pro Pro Pro Pro Arg Leu Pro 
                165                 170                 175     


Gly Tyr Gly Gly Pro Lys Val Glu Gly Asp Pro Glu Gly Arg Glu Met 
            180                 185                 190         


Glu Asp Asp Pro Ala Gly His His Asn Glu Tyr Glu Gly Ile Pro Met 
        195                 200                 205             


Ala Glu Glu Tyr Asp Tyr Val His Leu Lys Gly Met Asp Lys Ala Gln 
    210                 215                 220                 


Gly Ser Arg Pro Pro Asp Gln Ala Cys Thr Gly Asp Pro Glu Leu Pro 
225                 230                 235                 240 


Glu Arg Gly Met Pro Ala Pro Gln Glu Ala Leu Ser Pro Gly Glu Pro 
                245                 250                 255     


Leu Val Val Ser Thr Gly Asp Leu Gln Leu Leu Tyr Phe Tyr Ala Gly 
            260                 265                 270         


Gln Cys Gln Ser His Tyr Ser Ala Leu Gln Ala Ala Val Ala Ala Leu 
        275                 280                 285             


Met Ser Ser Thr Gln Ala Asn Gln Pro Pro Arg Leu Phe Val Pro His 
    290                 295                 300                 


Ser Lys Arg Val Val Val Ala Ala His Arg Leu Val Phe Val Gly Asp 
305                 310                 315                 320 


Thr Leu Gly Arg Leu Ala Ala Ser Ala Pro Leu Arg Ala Gln Val Arg 
                325                 330                 335     


Ala Ala Gly Thr Ala Leu Gly Gln Ala Leu Arg Ala Thr Val Leu Ala 
            340                 345                 350         


Val Lys Gly Ala Ala Leu Gly Tyr Pro Ser Ser Pro Ala Ile Gln Glu 
        355                 360                 365             


Met Val Gln Cys Val Thr Glu Leu Ala Gly Gln Ala Leu Gln Phe Thr 
    370                 375                 380                 


Thr Leu Leu Thr Ser Leu Ala Pro 
385                 390         


<210>  3420
<211>  1069
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFTUD1__Homo_sapiens__NP_001035700

<400>  3420

Met Val Leu Asn Ser Leu Asp Lys Met Ile Gln Leu Gln Lys Asn Thr 
1               5                   10                  15      


Ala Asn Ile Arg Asn Ile Cys Val Leu Ala His Val Asp His Gly Asn 
            20                  25                  30          


Glu Glu Tyr Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe 
        35                  40                  45              


Ser Ser Glu Val Ser Thr Ala Val Arg Ile Cys Asp Gly Cys Ile Ile 
    50                  55                  60                  


Val Val Asp Ala Val Glu Gly Val Cys Pro Gln Thr Gln Ala Val Leu 
65                  70                  75                  80  


Arg Gln Ala Trp Leu Glu Asn Ile Arg Pro Val Leu Val Ile Asn Lys 
                85                  90                  95      


Ile Asp Arg Leu Ile Val Glu Leu Lys Phe Thr Pro Gln Glu Ala Tyr 
            100                 105                 110         


Ser His Leu Lys Asn Ile Leu Glu Gln Ile Asn Ala Leu Thr Gly Thr 
        115                 120                 125             


Leu Phe Thr Ser Lys Val Leu Glu Glu Arg Ala Glu Arg Glu Thr Glu 
    130                 135                 140                 


Ser Gln Val Asn Pro Asn Ser Glu Gln Gly Glu Gln Val Tyr Asp Trp 
145                 150                 155                 160 


Ser Thr Gly Leu Glu Asp Thr Asp Asp Ser His Leu Tyr Phe Ser Pro 
                165                 170                 175     


Glu Gln Gly Asn Val Val Phe Thr Ser Ala Ile Asp Gly Trp Gly Phe 
            180                 185                 190         


Gly Ile Glu His Phe Ala Arg Ile Tyr Ser Gln Lys Ile Gly Ile Lys 
        195                 200                 205             


Lys Glu Val Leu Met Lys Thr Leu Trp Gly Asp Tyr Tyr Ile Asn Met 
    210                 215                 220                 


Lys Ala Lys Lys Ile Met Lys Gly Asp Gln Ala Lys Gly Lys Lys Pro 
225                 230                 235                 240 


Leu Phe Val Gln Leu Ile Leu Glu Asn Ile Trp Ser Leu Tyr Asp Ala 
                245                 250                 255     


Val Leu Lys Lys Asp Lys Asp Lys Ile Asp Lys Ile Val Thr Ser Leu 
            260                 265                 270         


Gly Leu Lys Ile Gly Ala Arg Glu Ala Arg His Ser Asp Pro Lys Val 
        275                 280                 285             


Gln Ile Asn Ala Ile Cys Ser Gln Trp Leu Pro Ile Ser His Ala Val 
    290                 295                 300                 


Leu Ala Met Val Cys Gln Lys Leu Pro Ser Pro Leu Asp Ile Thr Ala 
305                 310                 315                 320 


Glu Arg Val Glu Arg Leu Met Cys Thr Gly Ser Gln Thr Phe Asp Ser 
                325                 330                 335     


Phe Pro Pro Glu Thr Gln Ala Leu Lys Ala Ala Phe Met Lys Cys Gly 
            340                 345                 350         


Ser Glu Asp Thr Ala Pro Val Ile Ile Phe Val Ser Lys Met Phe Ala 
        355                 360                 365             


Val Asp Ala Lys Ala Leu Pro Gln Asn Lys Pro Arg Pro Leu Thr Gln 
    370                 375                 380                 


Glu Glu Ile Ala Gln Arg Arg Glu Arg Ala Arg Gln Arg His Ala Glu 
385                 390                 395                 400 


Lys Leu Ala Ala Ala Gln Gly Gln Ala Pro Leu Glu Pro Thr Gln Asp 
                405                 410                 415     


Gly Ser Ala Ile Glu Thr Cys Pro Lys Gly Glu Glu Pro Arg Gly Asp 
            420                 425                 430         


Glu Gln Gln Val Glu Ser Met Thr Pro Lys Pro Val Leu Gln Glu Glu 
        435                 440                 445             


Asn Asn Gln Glu Ser Phe Ile Ala Phe Ala Arg Val Phe Ser Gly Val 
    450                 455                 460                 


Ala Arg Arg Gly Lys Lys Ile Phe Val Leu Gly Pro Lys Tyr Ser Pro 
465                 470                 475                 480 


Leu Glu Phe Leu Arg Arg Val Pro Leu Gly Phe Ser Ala Pro Pro Asp 
                485                 490                 495     


Gly Leu Pro Gln Val Pro His Met Ala Tyr Cys Ala Leu Glu Asn Leu 
            500                 505                 510         


Tyr Leu Leu Met Gly Arg Glu Leu Glu Tyr Leu Glu Glu Val Pro Pro 
        515                 520                 525             


Gly Asn Val Leu Gly Ile Gly Gly Leu Gln Asp Phe Val Leu Lys Ser 
    530                 535                 540                 


Ala Thr Leu Cys Ser Leu Pro Ser Cys Pro Pro Phe Ile Pro Leu Asn 
545                 550                 555                 560 


Phe Glu Ala Thr Pro Ile Val Arg Val Ala Val Glu Pro Lys His Pro 
                565                 570                 575     


Ser Glu Met Pro Gln Leu Val Lys Gly Met Lys Leu Leu Asn Gln Ala 
            580                 585                 590         


Asp Pro Cys Val Gln Ile Leu Ile Gln Glu Thr Gly Glu His Val Leu 
        595                 600                 605             


Val Thr Ala Gly Glu Val His Leu Gln Arg Cys Leu Asp Asp Leu Lys 
    610                 615                 620                 


Glu Arg Phe Ala Lys Ile His Ile Ser Val Ser Glu Pro Ile Ile Pro 
625                 630                 635                 640 


Phe Arg Glu Thr Ile Thr Lys Pro Pro Lys Val Asp Met Val Asn Glu 
                645                 650                 655     


Glu Ile Gly Lys Gln Gln Lys Val Ala Val Ile His Gln Met Lys Glu 
            660                 665                 670         


Asp Gln Ser Lys Ile Pro Glu Gly Ile Gln Val Asp Ser Asp Gly Leu 
        675                 680                 685             


Ile Thr Ile Thr Thr Pro Asn Lys Leu Ala Thr Leu Ser Val Arg Ala 
    690                 695                 700                 


Met Pro Leu Pro Glu Glu Val Thr Gln Ile Leu Glu Glu Asn Ser Asp 
705                 710                 715                 720 


Leu Ile Arg Ser Met Glu Gln Leu Thr Ser Ser Leu Asn Glu Gly Glu 
                725                 730                 735     


Asn Thr His Met Ile His Gln Lys Thr Gln Glu Lys Ile Trp Glu Phe 
            740                 745                 750         


Lys Gly Lys Leu Glu Gln His Leu Thr Gly Arg Arg Trp Arg Asn Ile 
        755                 760                 765             


Val Asp Gln Ile Trp Ser Phe Gly Pro Arg Lys Cys Gly Pro Asn Ile 
    770                 775                 780                 


Leu Val Asn Lys Ser Glu Asp Phe Gln Asn Ser Val Trp Thr Gly Pro 
785                 790                 795                 800 


Ala Asp Lys Ala Ser Lys Glu Ala Ser Arg Tyr Arg Asp Leu Gly Asn 
                805                 810                 815     


Ser Ile Val Ser Gly Phe Gln Leu Ala Thr Leu Ser Gly Pro Met Cys 
            820                 825                 830         


Glu Glu Pro Leu Met Gly Val Cys Phe Val Leu Glu Lys Trp Asp Leu 
        835                 840                 845             


Ser Lys Phe Glu Glu Gln Gly Ala Ser Asp Leu Ala Lys Glu Gly Gln 
    850                 855                 860                 


Glu Glu Asn Glu Thr Cys Ser Gly Gly Asn Glu Asn Gln Glu Leu Gln 
865                 870                 875                 880 


Asp Gly Cys Ser Glu Ala Phe Glu Lys Arg Thr Ser Gln Lys Gly Glu 
                885                 890                 895     


Ser Pro Leu Thr Asp Cys Tyr Gly Pro Phe Ser Gly Gln Leu Ile Ala 
            900                 905                 910         


Thr Met Lys Glu Ala Cys Arg Tyr Ala Leu Gln Val Lys Pro Gln Arg 
        915                 920                 925             


Leu Met Ala Ala Met Tyr Thr Cys Asp Ile Met Ala Thr Gly Asp Val 
    930                 935                 940                 


Leu Gly Arg Val Tyr Ala Val Leu Ser Lys Arg Glu Gly Arg Val Leu 
945                 950                 955                 960 


Gln Glu Glu Met Lys Glu Gly Thr Asp Met Phe Ile Ile Lys Ala Val 
                965                 970                 975     


Leu Pro Val Ala Glu Ser Phe Gly Phe Ala Asp Glu Ile Arg Lys Arg 
            980                 985                 990         


Thr Ser Gly Leu Ala Ser Pro Gln  Leu Val Phe Ser His  Trp Glu Ile 
        995                 1000                 1005             


Ile Pro  Ser Asp Pro Phe Trp  Val Pro Thr Thr Glu  Glu Glu Tyr 
    1010                 1015                 1020             


Leu His  Phe Gly Glu Lys Ala  Asp Ser Glu Asn Gln  Ala Arg Lys 
    1025                 1030                 1035             


Tyr Met  Asn Ala Val Arg Lys  Arg Lys Gly Leu Tyr  Val Glu Glu 
    1040                 1045                 1050             


Lys Ile  Val Glu His Ala Glu  Lys Gln Arg Thr Leu  Ser Lys Asn 
    1055                 1060                 1065             


Lys 
    


<210>  3421
<211>  937
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFTUD2__Homo_sapiens__NP_001136077

<400>  3421

Met Asp Asp Asp Asp Asp Asp Asp Asp Val Gly Asp His Asp Asp Asp 
1               5                   10                  15      


His Pro Gly Met Glu Val Val Leu His Glu Asp Lys Lys Tyr Tyr Pro 
            20                  25                  30          


Thr Ala Glu Glu Val Tyr Gly Pro Glu Val Glu Thr Ile Val Gln Glu 
        35                  40                  45              


Glu Asp Thr Gln Pro Leu Thr Glu Pro Ile Ile Lys Pro Val Lys Thr 
    50                  55                  60                  


Lys Lys Phe Thr Leu Met Glu Gln Thr Leu Pro Val Thr Val Tyr Glu 
65                  70                  75                  80  


Met Asp Phe Leu Ala Asp Leu Met Asp Asn Ser Glu Leu Ile Arg Asn 
                85                  90                  95      


Val Thr Leu Cys Gly His Leu His His Gly Lys Thr Cys Phe Val Asp 
            100                 105                 110         


Cys Leu Ile Glu Gln Thr His Pro Glu Ile Arg Lys Arg Tyr Asp Gln 
        115                 120                 125             


Asp Leu Cys Tyr Thr Asp Ile Leu Phe Thr Glu Gln Glu Arg Gly Val 
    130                 135                 140                 


Gly Ile Lys Ser Thr Pro Val Thr Val Val Leu Pro Asp Thr Lys Gly 
145                 150                 155                 160 


Lys Ser Tyr Leu Phe Asn Ile Met Asp Thr Pro Gly His Val Asn Phe 
                165                 170                 175     


Ser Asp Glu Val Thr Ala Gly Leu Arg Ile Ser Asp Gly Val Val Leu 
            180                 185                 190         


Phe Ile Asp Ala Ala Glu Gly Val Met Leu Asn Thr Glu Arg Leu Ile 
        195                 200                 205             


Lys His Ala Val Gln Glu Arg Leu Ala Val Thr Val Cys Ile Asn Lys 
    210                 215                 220                 


Ile Asp Arg Leu Ile Leu Glu Leu Lys Leu Pro Pro Thr Asp Ala Tyr 
225                 230                 235                 240 


Tyr Lys Leu Arg His Ile Val Asp Glu Val Asn Gly Leu Ile Ser Met 
                245                 250                 255     


Tyr Ser Thr Asp Glu Asn Leu Ile Leu Ser Pro Leu Leu Gly Asn Val 
            260                 265                 270         


Cys Phe Ser Ser Ser Gln Tyr Ser Ile Cys Phe Thr Leu Gly Ser Phe 
        275                 280                 285             


Ala Lys Ile Tyr Ala Asp Thr Phe Gly Asp Ile Asn Tyr Gln Glu Phe 
    290                 295                 300                 


Ala Lys Arg Leu Trp Gly Asp Ile Tyr Phe Asn Pro Lys Thr Arg Lys 
305                 310                 315                 320 


Phe Thr Lys Lys Ala Pro Thr Ser Ser Ser Gln Arg Ser Phe Val Glu 
                325                 330                 335     


Phe Ile Leu Glu Pro Leu Tyr Lys Ile Leu Ala Gln Val Val Gly Asp 
            340                 345                 350         


Val Asp Thr Ser Leu Pro Arg Thr Leu Asp Glu Leu Gly Ile His Leu 
        355                 360                 365             


Thr Lys Glu Glu Leu Lys Leu Asn Ile Arg Pro Leu Leu Arg Leu Val 
    370                 375                 380                 


Cys Lys Lys Phe Phe Gly Glu Phe Thr Gly Phe Val Asp Met Cys Val 
385                 390                 395                 400 


Gln His Ile Pro Ser Pro Lys Val Gly Ala Lys Pro Lys Ile Glu His 
                405                 410                 415     


Thr Tyr Thr Gly Gly Val Asp Ser Asp Leu Gly Glu Ala Met Ser Asp 
            420                 425                 430         


Cys Asp Pro Asp Gly Pro Leu Met Cys His Thr Thr Lys Met Tyr Ser 
        435                 440                 445             


Thr Asp Asp Gly Val Gln Phe His Ala Phe Gly Arg Val Leu Ser Gly 
    450                 455                 460                 


Thr Ile His Ala Gly Gln Pro Val Lys Val Leu Gly Glu Asn Tyr Thr 
465                 470                 475                 480 


Leu Glu Asp Glu Glu Asp Ser Gln Ile Cys Thr Val Gly Arg Leu Trp 
                485                 490                 495     


Ile Ser Val Ala Arg Tyr His Ile Glu Val Asn Arg Val Pro Ala Gly 
            500                 505                 510         


Asn Trp Val Leu Ile Glu Gly Val Asp Gln Pro Ile Val Lys Thr Ala 
        515                 520                 525             


Thr Ile Thr Glu Pro Arg Gly Asn Glu Glu Ala Gln Ile Phe Arg Pro 
    530                 535                 540                 


Leu Lys Phe Asn Thr Thr Ser Val Ile Lys Ile Ala Val Glu Pro Val 
545                 550                 555                 560 


Asn Pro Ser Glu Leu Pro Lys Met Leu Asp Gly Leu Arg Lys Val Asn 
                565                 570                 575     


Lys Ser Tyr Pro Ser Leu Thr Thr Lys Val Glu Glu Ser Gly Glu His 
            580                 585                 590         


Val Ile Leu Gly Thr Gly Glu Leu Tyr Leu Asp Cys Val Met His Asp 
        595                 600                 605             


Leu Arg Lys Met Tyr Ser Glu Ile Asp Ile Lys Val Ala Asp Pro Val 
    610                 615                 620                 


Val Thr Phe Cys Glu Thr Val Val Glu Thr Ser Ser Leu Lys Cys Phe 
625                 630                 635                 640 


Ala Glu Thr Pro Asn Lys Lys Asn Lys Ile Thr Met Ile Ala Glu Pro 
                645                 650                 655     


Leu Glu Lys Gly Leu Ala Glu Asp Ile Glu Asn Glu Val Val Gln Ile 
            660                 665                 670         


Thr Trp Asn Arg Lys Lys Leu Gly Glu Phe Phe Gln Thr Lys Tyr Asp 
        675                 680                 685             


Trp Asp Leu Leu Ala Ala Arg Ser Ile Trp Ala Phe Gly Pro Asp Ala 
    690                 695                 700                 


Thr Gly Pro Asn Ile Leu Val Asp Asp Thr Leu Pro Ser Glu Val Asp 
705                 710                 715                 720 


Lys Ala Leu Leu Gly Ser Val Lys Asp Ser Ile Val Gln Gly Phe Gln 
                725                 730                 735     


Trp Gly Thr Arg Glu Gly Pro Leu Cys Asp Glu Leu Ile Arg Asn Val 
            740                 745                 750         


Lys Phe Lys Ile Leu Asp Ala Val Val Ala Gln Glu Pro Leu His Arg 
        755                 760                 765             


Gly Gly Gly Gln Ile Ile Pro Thr Ala Arg Arg Val Val Tyr Ser Ala 
    770                 775                 780                 


Phe Leu Met Ala Thr Pro Arg Leu Met Glu Pro Tyr Tyr Phe Val Glu 
785                 790                 795                 800 


Val Gln Ala Pro Ala Asp Cys Val Ser Ala Val Tyr Thr Val Leu Ala 
                805                 810                 815     


Arg Arg Arg Gly His Val Thr Gln Asp Ala Pro Ile Pro Gly Ser Pro 
            820                 825                 830         


Leu Tyr Thr Ile Lys Ala Phe Ile Pro Ala Ile Asp Ser Phe Gly Phe 
        835                 840                 845             


Glu Thr Asp Leu Arg Thr His Thr Gln Gly Gln Ala Phe Ser Leu Ser 
    850                 855                 860                 


Val Phe His His Trp Gln Ile Val Pro Gly Asp Pro Leu Asp Lys Ser 
865                 870                 875                 880 


Ile Val Ile Arg Pro Leu Glu Pro Gln Pro Ala Pro His Leu Ala Arg 
                885                 890                 895     


Glu Phe Met Ile Lys Thr Arg Arg Arg Lys Gly Leu Ser Glu Asp Val 
            900                 905                 910         


Ser Ile Ser Lys Phe Phe Asp Asp Pro Met Leu Leu Glu Leu Ala Lys 
        915                 920                 925             


Gln Asp Val Val Leu Asn Tyr Pro Met 
    930                 935         


<210>  3422
<211>  1166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGF__Homo_sapiens__NP_001171601

<400>  3422

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ser Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val 
        915                 920                 925             


Arg Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
    930                 935                 940                 


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
945                 950                 955                 960 


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
                965                 970                 975     


Lys Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val 
            980                 985                 990         


Ile Val Val Ala Val Cys Val Val  Val Leu Val Met Leu  Leu Leu Leu 
        995                 1000                 1005             


Ser Leu  Trp Gly Ala His Tyr  Tyr Arg Thr Gln Lys  Leu Leu Ser 
    1010                 1015                 1020             


Lys Asn  Pro Lys Asn Pro Tyr  Glu Glu Ser Ser Arg  Asp Val Arg 
    1025                 1030                 1035             


Ser Arg  Arg Pro Ala Asp Thr  Glu Asp Gly Met Ser  Ser Cys Pro 
    1040                 1045                 1050             


Gln Pro  Trp Phe Val Val Ile  Lys Glu His Gln Asp  Leu Lys Asn 
    1055                 1060                 1065             


Gly Gly  Gln Pro Val Ala Gly  Glu Asp Gly Gln Ala  Ala Asp Gly 
    1070                 1075                 1080             


Ser Met  Gln Pro Thr Ser Trp  Arg Gln Glu Pro Gln  Leu Cys Gly 
    1085                 1090                 1095             


Met Gly  Thr Glu Gln Gly Cys  Trp Ile Pro Val Ser  Ser Asp Lys 
    1100                 1105                 1110             


Gly Ser  Cys Pro Gln Val Met  Glu Arg Ser Phe His  Met Pro Ser 
    1115                 1120                 1125             


Tyr Gly  Thr Gln Thr Leu Glu  Gly Gly Val Glu Lys  Pro His Ser 
    1130                 1135                 1140             


Leu Leu  Ser Ala Asn Pro Leu  Trp Gln Gln Arg Ala  Leu Asp Pro 
    1145                 1150                 1155             


Pro His  Gln Met Glu Leu Thr  Gln 
    1160                 1165     


<210>  3423
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFL6__Homo_sapiens__NP_001161362

<400>  3423

Met Pro Leu Pro Trp Ser Leu Ala Leu Pro Leu Leu Leu Ser Trp Val 
1               5                   10                  15      


Ala Gly Gly Phe Gly Asn Ala Ala Ser Ala Arg His His Gly Leu Leu 
            20                  25                  30          


Ala Ser Ala Arg Gln Pro Gly Val Cys His Tyr Gly Thr Lys Leu Ala 
        35                  40                  45              


Cys Cys Tyr Gly Trp Arg Arg Asn Ser Lys Gly Val Cys Glu Ala Thr 
    50                  55                  60                  


Cys Glu Pro Gly Cys Lys Phe Gly Glu Cys Val Gly Pro Asn Lys Cys 
65                  70                  75                  80  


Arg Cys Phe Pro Gly Tyr Thr Gly Lys Thr Cys Ser Gln Asp Val Asn 
                85                  90                  95      


Glu Cys Gly Met Lys Pro Arg Pro Cys Gln His Arg Cys Val Asn Thr 
            100                 105                 110         


His Gly Ser Tyr Lys Cys Phe Cys Leu Ser Gly His Met Leu Met Pro 
        115                 120                 125             


Asp Ala Thr Cys Val Asn Ser Arg Thr Cys Ala Met Ile Asn Cys Gln 
    130                 135                 140                 


Tyr Ser Cys Glu Asp Thr Glu Glu Gly Pro Gln Cys Leu Cys Pro Ser 
145                 150                 155                 160 


Ser Gly Leu Arg Leu Ala Pro Asn Gly Arg Asp Cys Leu Asp Ile Asp 
                165                 170                 175     


Glu Cys Ala Ser Gly Lys Val Ile Cys Pro Tyr Asn Arg Arg Cys Val 
            180                 185                 190         


Asn Thr Phe Gly Ser Tyr Tyr Cys Lys Cys His Ile Gly Phe Glu Leu 
        195                 200                 205             


Gln Tyr Ile Ser Gly Arg Tyr Asp Cys Ile Asp Ile Asn Glu Cys Thr 
    210                 215                 220                 


Met Asp Ser His Thr Cys Ser His His Ala Asn Cys Phe Asn Thr Gln 
225                 230                 235                 240 


Gly Ser Phe Lys Cys Lys Cys Lys Gln Gly Tyr Lys Gly Asn Gly Leu 
                245                 250                 255     


Arg Cys Ser Ala Ile Pro Glu Asn Ser Val Lys Glu Val Leu Arg Ala 
            260                 265                 270         


Pro Gly Thr Ile Lys Asp Arg Ile Lys Lys Leu Leu Ala His Lys Asn 
        275                 280                 285             


Ser Met Lys Lys Lys Ala Lys Ile Lys Asn Val Thr Pro Glu Pro Thr 
    290                 295                 300                 


Arg Thr Pro Thr Pro Lys Val Asn Leu Gln Pro Phe Asn Tyr Glu Glu 
305                 310                 315                 320 


Ile Val Ser Arg Gly Gly Asn Ser His Gly Gly Lys Lys Gly Asn Glu 
                325                 330                 335     


Glu Lys Met Lys Glu Gly Leu Glu Asp Glu Lys Arg Glu Glu Lys Ala 
            340                 345                 350         


Leu Lys Asn Asp Ile Glu Glu Arg Ser Leu Arg Gly Asp Val Phe Phe 
        355                 360                 365             


Pro Lys Val Asn Glu Ala Gly Glu Phe Gly Leu Ile Leu Val Gln Arg 
    370                 375                 380                 


Lys Ala Leu Thr Ser Lys Leu Glu His Lys Ala Asp Leu Asn Ile Ser 
385                 390                 395                 400 


Val Asp Cys Ser Phe Asn His Gly Ile Cys Asp Trp Lys Gln Asp Arg 
                405                 410                 415     


Glu Asp Asp Phe Asp Trp Asn Pro Ala Asp Arg Asp Asn Ala Ile Gly 
            420                 425                 430         


Phe Tyr Met Ala Val Pro Ala Leu Ala Gly His Lys Lys Asp Ile Gly 
        435                 440                 445             


Arg Leu Lys Leu Leu Leu Pro Asp Leu Gln Pro Gln Ser Asn Phe Cys 
    450                 455                 460                 


Leu Leu Phe Asp Tyr Arg Leu Ala Gly Asp Lys Val Gly Lys Leu Arg 
465                 470                 475                 480 


Val Phe Val Lys Asn Ser Asn Asn Ala Leu Ala Trp Glu Lys Thr Thr 
                485                 490                 495     


Ser Glu Asp Glu Lys Trp Lys Thr Gly Lys Ile Gln Leu Tyr Gln Gly 
            500                 505                 510         


Thr Asp Ala Thr Lys Ser Ile Ile Phe Glu Ala Glu Arg Gly Lys Gly 
        515                 520                 525             


Lys Thr Gly Glu Ile Ala Val Asp Gly Val Leu Leu Val Ser Gly Leu 
    530                 535                 540                 


Cys Pro Asp Ser Leu Leu Ser Val Asp Asp 
545                 550                 


<210>  3424
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFL7__Homo_sapiens__XP_011517068

<400>  3424

Met Arg Gly Ser Gln Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala 
1               5                   10                  15      


Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala 
            20                  25                  30          


Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val 
        35                  40                  45              


Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr 
    50                  55                  60                  


Tyr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala 
65                  70                  75                  80  


Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser 
                85                  90                  95      


Gly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly 
        115                 120                 125             


Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu Cys Ser Ala Arg 
    130                 135                 140                 


Arg Gly Gly Cys Pro Gln Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp 
145                 150                 155                 160 


Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys 
                165                 170                 175     


Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Val 
            180                 185                 190         


Asp Ser Ala Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp 
        195                 200                 205             


Leu Leu Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu 
    210                 215                 220                 


Ala Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro Gly Ser Leu Leu 
225                 230                 235                 240 


Val His Ser Phe Gln Gln Leu Gly Arg Ile Asp Ser Leu Ser Glu Gln 
                245                 250                 255     


Ile Ser Phe Leu Glu Glu Gln Leu Gly Ser Cys Ser Cys Lys Lys Asp 
            260                 265                 270         


Ser 
    


<210>  3425
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFL8__Homo_sapiens__NP_085155

<400>  3425

Met Gly Ser Arg Ala Glu Leu Cys Thr Leu Leu Gly Gly Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Ile Pro Gly Glu Gly Ala Lys Gly Gly Ser Leu Arg 
            20                  25                  30          


Glu Ser Gln Gly Val Cys Ser Lys Gln Thr Leu Val Val Pro Leu His 
        35                  40                  45              


Tyr Asn Glu Ser Tyr Ser Gln Pro Val Tyr Lys Pro Tyr Leu Thr Leu 
    50                  55                  60                  


Cys Ala Gly Arg Arg Ile Cys Ser Thr Tyr Arg Thr Met Tyr Arg Val 
65                  70                  75                  80  


Met Trp Arg Glu Val Arg Arg Glu Val Gln Gln Thr His Ala Val Cys 
                85                  90                  95      


Cys Gln Gly Trp Lys Lys Arg His Pro Gly Ala Leu Thr Cys Glu Ala 
            100                 105                 110         


Ile Cys Ala Lys Pro Cys Leu Asn Gly Gly Val Cys Val Arg Pro Asp 
        115                 120                 125             


Gln Cys Glu Cys Ala Pro Gly Trp Gly Gly Lys His Cys His Val Asp 
    130                 135                 140                 


Val Asp Glu Cys Arg Thr Ser Ile Thr Leu Cys Ser His His Cys Phe 
145                 150                 155                 160 


Asn Thr Ala Gly Ser Phe Thr Cys Gly Cys Pro His Asp Leu Val Leu 
                165                 170                 175     


Gly Val Asp Gly Arg Thr Cys Met Glu Gly Ser Pro Glu Pro Pro Thr 
            180                 185                 190         


Ser Ala Ser Ile Leu Ser Val Ala Val Arg Glu Ala Glu Lys Asp Glu 
        195                 200                 205             


Arg Ala Leu Lys Gln Glu Ile His Glu Leu Arg Gly Arg Leu Glu Arg 
    210                 215                 220                 


Leu Glu Gln Trp Ala Gly Gln Ala Gly Ala Trp Val Arg Ala Val Leu 
225                 230                 235                 240 


Pro Val Pro Pro Glu Glu Leu Gln Pro Glu Gln Val Ala Glu Leu Trp 
                245                 250                 255     


Gly Arg Gly Asp Arg Ile Glu Ser Leu Ser Asp Gln Val Leu Leu Leu 
            260                 265                 270         


Glu Glu Arg Leu Gly Ala Cys Ser Cys Glu Asp Asn Ser Leu Gly Leu 
        275                 280                 285             


Gly Val Asn His Arg 
    290             


<210>  3426
<211>  1017
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFLAM__Homo_sapiens__NP_001192230

<400>  3426

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15      


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30          


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45              


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60                  


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80  


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95      


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110         


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125             


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140                 


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160 


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175     


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190         


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205             


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220                 


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240 


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255     


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270         


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285             


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300                 


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320 


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335     


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350         


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365             


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380                 


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400 


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415     


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430         


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445             


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460                 


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480 


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495     


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510         


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525             


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540                 


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560 


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575     


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590         


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605             


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620                 


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640 


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655     


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670         


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685             


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700                 


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720 


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735     


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750         


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765             


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780                 


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800 


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815     


Leu His Cys Gln Lys Glu Cys Gly Asn Tyr Cys Leu Asn Thr Ile Ile 
            820                 825                 830         


Glu Ala Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr 
        835                 840                 845             


Asp Asn Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val 
    850                 855                 860                 


Phe Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg 
865                 870                 875                 880 


Gly Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu 
                885                 890                 895     


Arg Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala 
            900                 905                 910         


Ser Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val 
        915                 920                 925             


Lys Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr 
    930                 935                 940                 


Gly Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile 
945                 950                 955                 960 


Asn Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr 
                965                 970                 975     


Asn Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr 
            980                 985                 990         


Leu Ser Thr Asp Tyr His Ile Ser  Leu Val Glu Asp Ala  Val Asp Gly 
        995                 1000                 1005             


Lys Asn  Ile Asn Thr Cys Gly  Ala Lys 
    1010                 1015         


<210>  3427
<211>  1210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR__Homo_sapiens__NP_005219

<400>  3427

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  3428
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGLN1__Homo_sapiens__NP_071334

<400>  3428

Met Ala Asn Asp Ser Gly Gly Pro Gly Gly Pro Ser Pro Ser Glu Arg 
1               5                   10                  15      


Asp Arg Gln Tyr Cys Glu Leu Cys Gly Lys Met Glu Asn Leu Leu Arg 
            20                  25                  30          


Cys Ser Arg Cys Arg Ser Ser Phe Tyr Cys Cys Lys Glu His Gln Arg 
        35                  40                  45              


Gln Asp Trp Lys Lys His Lys Leu Val Cys Gln Gly Ser Glu Gly Ala 
    50                  55                  60                  


Leu Gly His Gly Val Gly Pro His Gln His Ser Gly Pro Ala Pro Pro 
65                  70                  75                  80  


Ala Ala Val Pro Pro Pro Arg Ala Gly Ala Arg Glu Pro Arg Lys Ala 
                85                  90                  95      


Ala Ala Arg Arg Asp Asn Ala Ser Gly Asp Ala Ala Lys Gly Lys Val 
            100                 105                 110         


Lys Ala Lys Pro Pro Ala Asp Pro Ala Ala Ala Ala Ser Pro Cys Arg 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Ser Ala Val Ala Ala Glu Ala Glu Pro 
    130                 135                 140                 


Gly Lys Glu Glu Pro Pro Ala Arg Ser Ser Leu Phe Gln Glu Lys Ala 
145                 150                 155                 160 


Asn Leu Tyr Pro Pro Ser Asn Thr Pro Gly Asp Ala Leu Ser Pro Gly 
                165                 170                 175     


Gly Gly Leu Arg Pro Asn Gly Gln Thr Lys Pro Leu Pro Ala Leu Lys 
            180                 185                 190         


Leu Ala Leu Glu Tyr Ile Val Pro Cys Met Asn Lys His Gly Ile Cys 
        195                 200                 205             


Val Val Asp Asp Phe Leu Gly Lys Glu Thr Gly Gln Gln Ile Gly Asp 
    210                 215                 220                 


Glu Val Arg Ala Leu His Asp Thr Gly Lys Phe Thr Asp Gly Gln Leu 
225                 230                 235                 240 


Val Ser Gln Lys Ser Asp Ser Ser Lys Asp Ile Arg Gly Asp Lys Ile 
                245                 250                 255     


Thr Trp Ile Glu Gly Lys Glu Pro Gly Cys Glu Thr Ile Gly Leu Leu 
            260                 265                 270         


Met Ser Ser Met Asp Asp Leu Ile Arg His Cys Asn Gly Lys Leu Gly 
        275                 280                 285             


Ser Tyr Lys Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
    290                 295                 300                 


Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp 
305                 310                 315                 320 


Gly Arg Cys Val Thr Cys Ile Tyr Tyr Leu Asn Lys Asp Trp Asp Ala 
                325                 330                 335     


Lys Val Ser Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ala Gln 
            340                 345                 350         


Phe Ala Asp Ile Glu Pro Lys Phe Asp Arg Leu Leu Phe Phe Trp Ser 
        355                 360                 365             


Asp Arg Arg Asn Pro His Glu Val Gln Pro Ala Tyr Ala Thr Arg Tyr 
    370                 375                 380                 


Ala Ile Thr Val Trp Tyr Phe Asp Ala Asp Glu Arg Ala Arg Ala Lys 
385                 390                 395                 400 


Val Lys Tyr Leu Thr Gly Glu Lys Gly Val Arg Val Glu Leu Asn Lys 
                405                 410                 415     


Pro Ser Asp Ser Val Gly Lys Asp Val Phe 
            420                 425     


<210>  3429
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGLN2__Homo_sapiens__NP_444274

<400>  3429

Met Asp Ser Pro Cys Gln Pro Gln Pro Leu Ser Gln Ala Leu Pro Gln 
1               5                   10                  15      


Leu Pro Gly Ser Ser Ser Glu Pro Leu Glu Pro Glu Pro Gly Arg Ala 
            20                  25                  30          


Arg Met Gly Val Glu Ser Tyr Leu Pro Cys Pro Leu Leu Pro Ser Tyr 
        35                  40                  45              


His Cys Pro Gly Val Pro Ser Glu Ala Ser Ala Gly Ser Gly Thr Pro 
    50                  55                  60                  


Arg Ala Thr Ala Thr Ser Thr Thr Ala Ser Pro Leu Arg Asp Gly Phe 
65                  70                  75                  80  


Gly Gly Gln Asp Gly Gly Glu Leu Arg Pro Leu Gln Ser Glu Gly Ala 
                85                  90                  95      


Ala Ala Leu Val Thr Lys Gly Cys Gln Arg Leu Ala Ala Gln Gly Ala 
            100                 105                 110         


Arg Pro Glu Ala Pro Lys Arg Lys Trp Ala Glu Asp Gly Gly Asp Ala 
        115                 120                 125             


Pro Ser Pro Ser Lys Arg Pro Trp Ala Arg Gln Glu Asn Gln Glu Ala 
    130                 135                 140                 


Glu Arg Glu Gly Gly Met Ser Cys Ser Cys Ser Ser Gly Ser Gly Glu 
145                 150                 155                 160 


Ala Ser Ala Gly Leu Met Glu Glu Ala Leu Pro Ser Ala Pro Glu Arg 
                165                 170                 175     


Leu Ala Leu Asp Tyr Ile Val Pro Cys Met Arg Tyr Tyr Gly Ile Cys 
            180                 185                 190         


Val Lys Asp Ser Phe Leu Gly Ala Ala Leu Gly Gly Arg Val Leu Ala 
        195                 200                 205             


Glu Val Glu Ala Leu Lys Arg Gly Gly Arg Leu Arg Asp Gly Gln Leu 
    210                 215                 220                 


Val Ser Gln Arg Ala Ile Pro Pro Arg Ser Ile Arg Gly Asp Gln Ile 
225                 230                 235                 240 


Ala Trp Val Glu Gly His Glu Pro Gly Cys Arg Ser Ile Gly Ala Leu 
                245                 250                 255     


Met Ala His Val Asp Ala Val Ile Arg His Cys Ala Gly Arg Leu Gly 
            260                 265                 270         


Ser Tyr Val Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
        275                 280                 285             


Gly Asn Gly Leu Gly Tyr Val Arg His Val Asp Asn Pro His Gly Asp 
    290                 295                 300                 


Gly Arg Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Gln Asn Trp Asp Val 
305                 310                 315                 320 


Lys Val His Gly Gly Leu Leu Gln Ile Phe Pro Glu Gly Arg Pro Val 
                325                 330                 335     


Val Ala Asn Ile Glu Pro Leu Phe Asp Arg Leu Leu Ile Phe Trp Ser 
            340                 345                 350         


Asp Arg Arg Asn Pro His Glu Val Lys Pro Ala Tyr Ala Thr Arg Tyr 
        355                 360                 365             


Ala Ile Thr Val Trp Tyr Phe Asp Ala Lys Glu Arg Ala Ala Ala Lys 
    370                 375                 380                 


Asp Lys Tyr Gln Leu Ala Ser Gly Gln Lys Gly Val Gln Val Pro Val 
385                 390                 395                 400 


Ser Gln Pro Pro Thr Pro Thr 
                405         


<210>  3430
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGLN3__Homo_sapiens__NP_071356

<400>  3430

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
            20                  25                  30          


Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
        35                  40                  45              


Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
    50                  55                  60                  


Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
65                  70                  75                  80  


Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                85                  90                  95      


Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
            100                 105                 110         


Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
        115                 120                 125             


Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
    130                 135                 140                 


Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
145                 150                 155                 160 


His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                165                 170                 175     


Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
            180                 185                 190         


Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
        195                 200                 205             


Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
    210                 215                 220                 


Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp 
225                 230                 235                 


<210>  3431
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGR1__Homo_sapiens__NP_001955

<400>  3431

Met Ala Ala Ala Lys Ala Glu Met Gln Leu Met Ser Pro Leu Gln Ile 
1               5                   10                  15      


Ser Asp Pro Phe Gly Ser Phe Pro His Ser Pro Thr Met Asp Asn Tyr 
            20                  25                  30          


Pro Lys Leu Glu Glu Met Met Leu Leu Ser Asn Gly Ala Pro Gln Phe 
        35                  40                  45              


Leu Gly Ala Ala Gly Ala Pro Glu Gly Ser Gly Ser Asn Ser Ser Ser 
    50                  55                  60                  


Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Asn Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Thr Phe Asn Pro Gln Ala Asp Thr Gly Glu Gln Pro 
                85                  90                  95      


Tyr Glu His Leu Thr Ala Glu Ser Phe Pro Asp Ile Ser Leu Asn Asn 
            100                 105                 110         


Glu Lys Val Leu Val Glu Thr Ser Tyr Pro Ser Gln Thr Thr Arg Leu 
        115                 120                 125             


Pro Pro Ile Thr Tyr Thr Gly Arg Phe Ser Leu Glu Pro Ala Pro Asn 
    130                 135                 140                 


Ser Gly Asn Thr Leu Trp Pro Glu Pro Leu Phe Ser Leu Val Ser Gly 
145                 150                 155                 160 


Leu Val Ser Met Thr Asn Pro Pro Ala Ser Ser Ser Ser Ala Pro Ser 
                165                 170                 175     


Pro Ala Ala Ser Ser Ala Ser Ala Ser Gln Ser Pro Pro Leu Ser Cys 
            180                 185                 190         


Ala Val Pro Ser Asn Asp Ser Ser Pro Ile Tyr Ser Ala Ala Pro Thr 
        195                 200                 205             


Phe Pro Thr Pro Asn Thr Asp Ile Phe Pro Glu Pro Gln Ser Gln Ala 
    210                 215                 220                 


Phe Pro Gly Ser Ala Gly Thr Ala Leu Gln Tyr Pro Pro Pro Ala Tyr 
225                 230                 235                 240 


Pro Ala Ala Lys Gly Gly Phe Gln Val Pro Met Ile Pro Asp Tyr Leu 
                245                 250                 255     


Phe Pro Gln Gln Gln Gly Asp Leu Gly Leu Gly Thr Pro Asp Gln Lys 
            260                 265                 270         


Pro Phe Gln Gly Leu Glu Ser Arg Thr Gln Gln Pro Ser Leu Thr Pro 
        275                 280                 285             


Leu Ser Thr Ile Lys Ala Phe Ala Thr Gln Ser Gly Ser Gln Asp Leu 
    290                 295                 300                 


Lys Ala Leu Asn Thr Ser Tyr Gln Ser Gln Leu Ile Lys Pro Ser Arg 
305                 310                 315                 320 


Met Arg Lys Tyr Pro Asn Arg Pro Ser Lys Thr Pro Pro His Glu Arg 
                325                 330                 335     


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            340                 345                 350         


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        355                 360                 365             


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    370                 375                 380                 


Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
385                 390                 395                 400 


Cys Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His Thr Lys 
                405                 410                 415     


Ile His Leu Arg Gln Lys Asp Lys Lys Ala Asp Lys Ser Val Val Ala 
            420                 425                 430         


Ser Ser Ala Thr Ser Ser Leu Ser Ser Tyr Pro Ser Pro Val Ala Thr 
        435                 440                 445             


Ser Tyr Pro Ser Pro Val Thr Thr Ser Tyr Pro Ser Pro Ala Thr Thr 
    450                 455                 460                 


Ser Tyr Pro Ser Pro Val Pro Thr Ser Phe Ser Ser Pro Gly Ser Ser 
465                 470                 475                 480 


Thr Tyr Pro Ser Pro Val His Ser Gly Phe Pro Ser Pro Ser Val Ala 
                485                 490                 495     


Thr Thr Tyr Ser Ser Val Pro Pro Ala Phe Pro Ala Gln Val Ser Ser 
            500                 505                 510         


Phe Pro Ser Ser Ala Val Thr Asn Ser Phe Ser Ala Ser Thr Gly Leu 
        515                 520                 525             


Ser Asp Met Thr Ala Thr Phe Ser Pro Arg Thr Ile Glu Ile Cys 
    530                 535                 540             


<210>  3432
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGR2__Homo_sapiens__NP_001129650

<400>  3432

Met Met Thr Ala Lys Ala Val Asp Lys Ile Pro Val Thr Leu Ser Gly 
1               5                   10                  15      


Phe Val His Gln Leu Ser Asp Asn Ile Tyr Pro Val Glu Asp Leu Ala 
            20                  25                  30          


Ala Thr Ser Val Thr Ile Phe Pro Asn Ala Glu Leu Gly Gly Pro Phe 
        35                  40                  45              


Asp Gln Met Asn Gly Val Ala Gly Asp Gly Met Ile Asn Ile Asp Met 
    50                  55                  60                  


Thr Gly Glu Lys Arg Ser Leu Asp Leu Pro Tyr Pro Ser Ser Phe Ala 
65                  70                  75                  80  


Pro Val Ser Ala Pro Arg Asn Gln Thr Phe Thr Tyr Met Gly Lys Phe 
                85                  90                  95      


Ser Ile Asp Pro Gln Tyr Pro Gly Ala Ser Cys Tyr Pro Glu Gly Ile 
            100                 105                 110         


Ile Asn Ile Val Ser Ala Gly Ile Leu Gln Gly Val Thr Ser Pro Ala 
        115                 120                 125             


Ser Thr Thr Ala Ser Ser Ser Val Thr Ser Ala Ser Pro Asn Pro Leu 
    130                 135                 140                 


Ala Thr Gly Pro Leu Gly Val Cys Thr Met Ser Gln Thr Gln Pro Asp 
145                 150                 155                 160 


Leu Asp His Leu Tyr Ser Pro Pro Pro Pro Pro Pro Pro Tyr Ser Gly 
                165                 170                 175     


Cys Ala Gly Asp Leu Tyr Gln Asp Pro Ser Ala Phe Leu Ser Ala Ala 
            180                 185                 190         


Thr Thr Ser Thr Ser Ser Ser Leu Ala Tyr Pro Pro Pro Pro Ser Tyr 
        195                 200                 205             


Pro Ser Pro Lys Pro Ala Thr Asp Pro Gly Leu Phe Pro Met Ile Pro 
    210                 215                 220                 


Asp Tyr Pro Gly Phe Phe Pro Ser Gln Cys Gln Arg Asp Leu His Gly 
225                 230                 235                 240 


Thr Ala Gly Pro Asp Arg Lys Pro Phe Pro Cys Pro Leu Asp Thr Leu 
                245                 250                 255     


Arg Val Pro Pro Pro Leu Thr Pro Leu Ser Thr Ile Arg Asn Phe Thr 
            260                 265                 270         


Leu Gly Gly Pro Ser Ala Gly Val Thr Gly Pro Gly Ala Ser Gly Gly 
        275                 280                 285             


Ser Glu Gly Pro Arg Leu Pro Gly Ser Ser Ser Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Tyr Asn Pro His His Leu Pro Leu Arg Pro Ile 
305                 310                 315                 320 


Leu Arg Pro Arg Lys Tyr Pro Asn Arg Pro Ser Lys Thr Pro Val His 
                325                 330                 335     


Glu Arg Pro Tyr Pro Cys Pro Ala Glu Gly Cys Asp Arg Arg Phe Ser 
            340                 345                 350         


Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly His Lys 
        355                 360                 365             


Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His 
    370                 375                 380                 


Leu Thr Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys 
385                 390                 395                 400 


Asp Tyr Cys Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His 
                405                 410                 415     


Thr Lys Ile His Leu Arg Gln Lys Glu Arg Lys Ser Ser Ala Pro Ser 
            420                 425                 430         


Ala Ser Val Pro Ala Pro Ser Thr Ala Ser Cys Ser Gly Gly Val Gln 
        435                 440                 445             


Pro Gly Gly Thr Leu Cys Ser Ser Asn Ser Ser Ser Leu Gly Gly Gly 
    450                 455                 460                 


Pro Leu Ala Pro Cys Ser Ser Arg Thr Arg Thr Pro 
465                 470                 475     


<210>  3433
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGR3__Homo_sapiens__NP_001186810

<400>  3433

Met Asp Ile Gly Leu Thr Asn Glu Lys Pro Asn Pro Glu Leu Ser Tyr 
1               5                   10                  15      


Ser Gly Ser Phe Gln Pro Ala Pro Gly Asn Lys Thr Val Thr Tyr Leu 
            20                  25                  30          


Gly Lys Phe Ala Phe Asp Ser Pro Ser Asn Trp Cys Gln Asp Asn Ile 
        35                  40                  45              


Ile Ser Leu Met Ser Ala Gly Ile Leu Gly Val Pro Pro Ala Ser Gly 
    50                  55                  60                  


Ala Leu Ser Thr Gln Thr Ser Thr Ala Ser Met Val Gln Pro Pro Gln 
65                  70                  75                  80  


Gly Asp Val Glu Ala Met Tyr Pro Ala Leu Pro Pro Tyr Ser Asn Cys 
                85                  90                  95      


Gly Asp Leu Tyr Ser Glu Pro Val Ser Phe His Asp Pro Gln Gly Asn 
            100                 105                 110         


Pro Gly Leu Ala Tyr Ser Pro Gln Asp Tyr Gln Ser Ala Lys Pro Ala 
        115                 120                 125             


Leu Asp Ser Asn Leu Phe Pro Met Ile Pro Asp Tyr Asn Leu Tyr His 
    130                 135                 140                 


His Pro Asn Asp Met Gly Ser Ile Pro Glu His Lys Pro Phe Gln Gly 
145                 150                 155                 160 


Met Asp Pro Ile Arg Val Asn Pro Pro Pro Ile Thr Pro Leu Glu Thr 
                165                 170                 175     


Ile Lys Ala Phe Lys Asp Lys Gln Ile His Pro Gly Phe Gly Ser Leu 
            180                 185                 190         


Pro Gln Pro Pro Leu Thr Leu Lys Pro Ile Arg Pro Arg Lys Tyr Pro 
        195                 200                 205             


Asn Arg Pro Ser Lys Thr Pro Leu His Glu Arg Pro His Ala Cys Pro 
    210                 215                 220                 


Ala Glu Gly Cys Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg 
225                 230                 235                 240 


His Leu Arg Ile His Thr Gly His Lys Pro Phe Gln Cys Arg Ile Cys 
                245                 250                 255     


Met Arg Ser Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr 
            260                 265                 270         


His Thr Gly Glu Lys Pro Phe Ala Cys Glu Phe Cys Gly Arg Lys Phe 
        275                 280                 285             


Ala Arg Ser Asp Glu Arg Lys Arg His Ala Lys Ile His Leu Lys Gln 
    290                 295                 300                 


Lys Glu Lys Lys Ala Glu Lys Gly Gly Ala Pro Ser Ala Ser Ser Ala 
305                 310                 315                 320 


Pro Pro Val Ser Leu Ala Pro Val Val Thr Thr Cys Ala 
                325                 330             


<210>  3434
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGR4__Homo_sapiens__NP_001956

<400>  3434

Met Ala Val Ala Arg Gly Val Gly Ser Pro Glu Pro Ala Pro Pro Gln 
1               5                   10                  15      


Leu Tyr Lys Trp Gly Gly Cys Gly Leu Gly Glu Pro Gly Ser Ala Leu 
            20                  25                  30          


Glu Arg Arg Gly Ala Ala Ala Arg Gly Arg Cys Gly Arg Ala Arg Ala 
        35                  40                  45              


Pro Arg Leu Pro Asp Ser Phe Pro Arg Gly Glu Cys Pro Lys Pro Gly 
    50                  55                  60                  


Ala Arg Ala Pro Arg Ser Val Arg Cys Gly Glu Pro Leu Pro Pro Ala 
65                  70                  75                  80  


Ser Pro Pro Pro Ala Arg Pro Gln Ala Gln Arg Ala Arg Pro Arg Ala 
                85                  90                  95      


Pro His Ser Arg Arg Arg Ala Met Leu His Leu Ser Glu Phe Ser Glu 
            100                 105                 110         


Pro Asp Ala Leu Leu Val Lys Ser Thr Glu Gly Cys Cys Ala Glu Pro 
        115                 120                 125             


Ser Ala Glu Leu Pro Arg Leu Pro Ala Arg Asp Ala Pro Ala Ala Thr 
    130                 135                 140                 


Gly Tyr Pro Gly Ala Gly Asp Phe Leu Ser Trp Ala Leu Asn Ser Cys 
145                 150                 155                 160 


Gly Ala Ser Gly Asp Leu Ala Asp Ser Cys Phe Leu Glu Gly Pro Ala 
                165                 170                 175     


Pro Thr Pro Pro Pro Gly Leu Ser Tyr Ser Gly Ser Phe Phe Ile Gln 
            180                 185                 190         


Ala Val Pro Glu His Pro His Asp Pro Glu Ala Leu Phe Asn Leu Met 
        195                 200                 205             


Ser Gly Ile Leu Gly Leu Ala Pro Phe Pro Gly Pro Glu Ala Ala Ala 
    210                 215                 220                 


Ser Arg Ser Pro Leu Asp Ala Pro Phe Pro Ala Gly Ser Asp Ala Leu 
225                 230                 235                 240 


Leu Pro Gly Pro Pro Asp Leu Tyr Ser Pro Asp Leu Gly Ala Ala Pro 
                245                 250                 255     


Phe Pro Glu Ala Phe Trp Glu Ala Ser Pro Cys Ala Gly Ala Pro Ser 
            260                 265                 270         


Gln Cys Leu Tyr Glu Pro Gln Leu Ser Pro Pro Asp Val Lys Pro Gly 
        275                 280                 285             


Leu Arg Ala Pro Pro Ala Ser Pro Ala Leu Asp Ala Val Ser Ala Phe 
    290                 295                 300                 


Lys Gly Pro Tyr Ala Pro Trp Glu Leu Leu Ser Val Gly Ala Pro Gly 
305                 310                 315                 320 


Asn Cys Gly Ser Gln Gly Asp Tyr Gln Ala Ala Pro Glu Ala Arg Phe 
                325                 330                 335     


Pro Val Ile Gly Thr Lys Ile Glu Asp Leu Leu Ser Ile Ser Cys Pro 
            340                 345                 350         


Ala Glu Leu Pro Ala Val Pro Ala Asn Arg Leu Tyr Pro Ser Gly Ala 
        355                 360                 365             


Tyr Asp Ala Phe Pro Leu Ala Pro Gly Asp Leu Gly Glu Gly Ala Glu 
    370                 375                 380                 


Gly Leu Pro Gly Leu Leu Thr Pro Pro Ser Gly Glu Gly Gly Ser Ser 
385                 390                 395                 400 


Gly Asp Gly Gly Glu Phe Leu Ala Ser Thr Gln Pro Gln Leu Ser Pro 
                405                 410                 415     


Leu Gly Leu Arg Ser Ala Ala Ala Ala Asp Phe Pro Lys Pro Leu Val 
            420                 425                 430         


Ala Asp Ile Pro Gly Ser Ser Gly Val Ala Ala Pro Pro Val Pro Pro 
        435                 440                 445             


Pro Pro Pro Thr Pro Phe Pro Gln Ala Lys Ala Arg Arg Lys Gly Arg 
    450                 455                 460                 


Arg Gly Gly Lys Cys Ser Thr Arg Cys Phe Cys Pro Arg Pro His Ala 
465                 470                 475                 480 


Lys Ala Phe Ala Cys Pro Val Glu Ser Cys Val Arg Ser Phe Ala Arg 
                485                 490                 495     


Ser Asp Glu Leu Asn Arg His Leu Arg Ile His Thr Gly His Lys Pro 
            500                 505                 510         


Phe Gln Cys Arg Ile Cys Leu Arg Asn Phe Ser Arg Ser Asp His Leu 
        515                 520                 525             


Thr Thr His Val Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp 
    530                 535                 540                 


Val Cys Gly Arg Arg Phe Ala Arg Ser Asp Glu Lys Lys Arg His Ser 
545                 550                 555                 560 


Lys Val His Leu Lys Gln Lys Ala Arg Ala Glu Glu Arg Leu Lys Gly 
                565                 570                 575     


Leu Gly Phe Tyr Ser Leu Gly Leu Ser Phe Ala Ser Leu 
            580                 585                 


<210>  3435
<211>  1160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHBP1__Homo_sapiens__NP_001136087

<400>  3435

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80  


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95      


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
            100                 105                 110         


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125             


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140                 


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160 


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175     


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190         


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205             


Lys Ile Thr Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp Glu Ala Glu 
    210                 215                 220                 


Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp Pro Asp Ala 
225                 230                 235                 240 


Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu Pro Ile Thr 
                245                 250                 255     


Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr Asn Asn Ser 
            260                 265                 270         


Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu Asn Pro Phe 
        275                 280                 285             


Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro Pro Gln Ser 
    290                 295                 300                 


Thr Lys Arg Lys Asn Ile Arg Pro Val Asp Met Ser Lys Tyr Leu Tyr 
305                 310                 315                 320 


Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu Ser Asn Pro 
                325                 330                 335     


Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu Val Asn Pro 
            340                 345                 350         


Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys Ala Pro Ala 
        355                 360                 365             


Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu Asn Thr Val 
    370                 375                 380                 


Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser Pro Ile Pro 
385                 390                 395                 400 


Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser Leu Leu Val 
                405                 410                 415     


Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys Ile Thr Asn 
            420                 425                 430         


Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala Ile Leu His 
        435                 440                 445             


His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn Pro Gln Asp 
    450                 455                 460                 


Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala Ser Ile Gly 
465                 470                 475                 480 


Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu Ala Ile Pro 
                485                 490                 495     


Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg Ala His Phe 
            500                 505                 510         


Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn Ser Ser Lys 
        515                 520                 525             


Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn Ser Ser Val 
    530                 535                 540                 


Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys Arg Glu Pro 
545                 550                 555                 560 


Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu Ser Gln Asp 
                565                 570                 575     


Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser Glu Ser Glu 
            580                 585                 590         


His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala Ser Pro Tyr 
        595                 600                 605             


Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser Gln Gln Ser 
    610                 615                 620                 


Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys Ser Asn Thr 
625                 630                 635                 640 


Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg Leu Leu Lys 
                645                 650                 655     


Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp Lys Lys Lys 
            660                 665                 670         


Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu Gln Lys Leu 
        675                 680                 685             


Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys Leu Glu Asn 
    690                 695                 700                 


Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro Ile Lys Lys 
705                 710                 715                 720 


Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr Ser Arg Asp 
                725                 730                 735     


Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln Thr Glu Ser 
            740                 745                 750         


Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp His Ser Ser 
        755                 760                 765             


Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu Leu Lys Glu 
    770                 775                 780                 


Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala Ala Leu Lys 
785                 790                 795                 800 


Ala Gly Asn Lys His Asn Thr Asn Thr Ala Thr Pro Phe Cys Asn Arg 
                805                 810                 815     


Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln Leu Arg Glu 
            820                 825                 830         


Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Val Lys Met Ser 
        835                 840                 845             


Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala Glu Lys Leu Lys Glu Arg 
    850                 855                 860                 


Ser Lys Ala Ser Gly Glu Gln Asn Ser Lys Leu Val Asp Leu Lys Leu 
865                 870                 875                 880 


Lys Lys Leu Leu Glu Val Gln Pro Gln Val Ala Asn Ser Pro Ser Ser 
                885                 890                 895     


Ala Ala Gln Lys Ala Val Thr Glu Ser Ser Glu Gln Asp Met Lys Ser 
            900                 905                 910         


Gly Thr Glu Asp Leu Arg Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg 
        915                 920                 925             


Phe Arg Asn Pro Val Val Phe Ser Lys Asp Ser Thr Val Arg Lys Thr 
    930                 935                 940                 


Gln Leu Gln Ser Phe Ser Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys 
945                 950                 955                 960 


Arg Gln Arg Ser Ile Gln Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys 
                965                 970                 975     


Ala Ala Ile Thr Glu Thr Gln Arg Lys Pro Ser Glu Asp Glu Val Leu 
            980                 985                 990         


Asn Lys Gly Phe Lys Asp Thr Ser  Gln Tyr Val Val Gly  Glu Leu Ala 
        995                 1000                 1005             


Ala Leu  Glu Asn Glu Gln Lys  Gln Ile Asp Thr Arg  Ala Ala Leu 
    1010                 1015                 1020             


Val Glu  Lys Arg Leu Arg Tyr  Leu Met Asp Thr Gly  Arg Asn Thr 
    1025                 1030                 1035             


Glu Glu  Glu Glu Ala Met Met  Gln Glu Trp Phe Met  Leu Val Asn 
    1040                 1045                 1050             


Lys Lys  Asn Ala Leu Ile Arg  Arg Met Asn Gln Leu  Ser Leu Leu 
    1055                 1060                 1065             


Glu Lys  Glu His Asp Leu Glu  Arg Arg Tyr Glu Leu  Leu Asn Arg 
    1070                 1075                 1080             


Glu Leu  Arg Ala Met Leu Ala  Ile Glu Asp Trp Gln  Lys Thr Glu 
    1085                 1090                 1095             


Ala Gln  Lys Arg Arg Glu Gln  Leu Leu Leu Asp Glu  Leu Val Ala 
    1100                 1105                 1110             


Leu Val  Asn Lys Arg Asp Ala  Leu Val Arg Asp Leu  Asp Ala Gln 
    1115                 1120                 1125             


Glu Lys  Gln Ala Glu Glu Glu  Asp Glu His Leu Glu  Arg Thr Leu 
    1130                 1135                 1140             


Glu Gln  Asn Lys Gly Lys Met  Ala Lys Lys Glu Glu  Lys Cys Val 
    1145                 1150                 1155             


Leu Gln  
    1160 


<210>  3436
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHD1__Homo_sapiens__NP_001269374

<400>  3436

Met Glu Gln Pro Gly Thr Ala Ala Ser Pro Val Ser Gly Ser Met Phe 
1               5                   10                  15      


Ser Trp Val Ser Lys Asp Ala Arg Arg Lys Lys Glu Pro Glu Leu Phe 
            20                  25                  30          


Gln Thr Val Ala Glu Gly Leu Arg Gln Leu Tyr Ala Gln Lys Leu Leu 
        35                  40                  45              


Pro Leu Glu Glu His Tyr Arg Phe His Glu Phe His Ser Pro Ala Leu 
    50                  55                  60                  


Glu Asp Ala Asp Phe Asp Asn Lys Pro Met Val Leu Leu Val Gly Gln 
65                  70                  75                  80  


Tyr Ser Thr Gly Lys Thr Thr Phe Ile Arg His Leu Ile Glu Gln Asp 
                85                  90                  95      


Phe Pro Gly Met Arg Ile Gly Pro Glu Pro Thr Thr Asp Ser Phe Ile 
            100                 105                 110         


Ala Val Met His Gly Pro Thr Glu Gly Val Val Pro Gly Asn Ala Leu 
        115                 120                 125             


Val Val Asp Pro Arg Arg Pro Phe Arg Lys Leu Asn Ala Phe Gly Asn 
    130                 135                 140                 


Ala Phe Leu Asn Arg Phe Met Cys Ala Gln Leu Pro Asn Pro Val Leu 
145                 150                 155                 160 


Asp Ser Ile Ser Ile Ile Asp Thr Pro Gly Ile Leu Ser Gly Glu Lys 
                165                 170                 175     


Gln Arg Ile Ser Arg Gly Tyr Asp Phe Ala Ala Val Leu Glu Trp Phe 
            180                 185                 190         


Ala Glu Arg Val Asp Arg Ile Ile Leu Leu Phe Asp Ala His Lys Leu 
        195                 200                 205             


Asp Ile Ser Asp Glu Phe Ser Glu Val Ile Lys Ala Leu Lys Asn His 
    210                 215                 220                 


Glu Asp Lys Ile Arg Val Val Leu Asn Lys Ala Asp Gln Ile Glu Thr 
225                 230                 235                 240 


Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met Trp Ser Leu Gly Lys 
                245                 250                 255     


Ile Ile Asn Thr Pro Glu Val Val Arg Val Tyr Ile Gly Ser Phe Trp 
            260                 265                 270         


Ser His Pro Leu Leu Ile Pro Asp Asn Arg Lys Leu Phe Glu Ala Glu 
        275                 280                 285             


Glu Gln Asp Leu Phe Lys Asp Ile Gln Ser Leu Pro Arg Asn Ala Ala 
    290                 295                 300                 


Leu Arg Lys Leu Asn Asp Leu Ile Lys Arg Ala Arg Leu Ala Lys Val 
305                 310                 315                 320 


His Ala Tyr Ile Ile Ser Ser Leu Lys Lys Glu Met Pro Asn Val Phe 
                325                 330                 335     


Gly Lys Glu Ser Lys Lys Lys Glu Leu Val Asn Asn Leu Gly Glu Ile 
            340                 345                 350         


Tyr Gln Lys Ile Glu Arg Glu His Gln Ile Ser Pro Gly Asp Phe Pro 
        355                 360                 365             


Ser Leu Arg Lys Met Gln Glu Leu Leu Gln Thr Gln Asp Phe Ser Lys 
    370                 375                 380                 


Phe Gln Ala Leu Lys Pro Lys Leu Leu Asp Thr Val Asp Asp Met Leu 
385                 390                 395                 400 


Ala Asn Asp Ile Ala Arg Leu Met Val Met Val Arg Gln Glu Glu Ser 
                405                 410                 415     


Leu Met Pro Ser Gln Val Val Lys Gly Gly Ala Phe Asp Gly Thr Met 
            420                 425                 430         


Asn Gly Pro Phe Gly His Gly Tyr Gly Glu Gly Ala Gly Glu Gly Ile 
        435                 440                 445             


Asp Asp Val Glu Trp Val Val Gly Lys Asp Lys Pro Thr Tyr Asp Glu 
    450                 455                 460                 


Ile Phe Tyr Thr Leu Ser Pro Val Asn Gly Lys Ile Thr Gly Ala Asn 
465                 470                 475                 480 


Ala Lys Lys Glu Met Val Lys Ser Lys Leu Pro Asn Thr Val Leu Gly 
                485                 490                 495     


Lys Ile Trp Lys Leu Ala Asp Val Asp Lys Asp Gly Leu Leu Asp Asp 
            500                 505                 510         


Glu Glu Phe Ala Leu Ala Asn His Leu Ile Lys Val Lys Leu Glu Gly 
        515                 520                 525             


His Glu Leu Pro Ala Asp Leu Pro Pro His Leu Val Pro Pro Ser Lys 
    530                 535                 540                 


Arg Arg His Glu 
545             


<210>  3437
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHD2__Homo_sapiens__NP_055416

<400>  3437

Met Phe Ser Trp Leu Lys Arg Gly Gly Ala Arg Gly Gln Gln Pro Glu 
1               5                   10                  15      


Ala Ile Arg Thr Val Thr Ser Ala Leu Lys Glu Leu Tyr Arg Thr Lys 
            20                  25                  30          


Leu Leu Pro Leu Glu Glu His Tyr Arg Phe Gly Ala Phe His Ser Pro 
        35                  40                  45              


Ala Leu Glu Asp Ala Asp Phe Asp Gly Lys Pro Met Val Leu Val Ala 
    50                  55                  60                  


Gly Gln Tyr Ser Thr Gly Lys Thr Ser Phe Ile Gln Tyr Leu Leu Glu 
65                  70                  75                  80  


Gln Glu Val Pro Gly Ser Arg Val Gly Pro Glu Pro Thr Thr Asp Cys 
                85                  90                  95      


Phe Val Ala Val Met His Gly Asp Thr Glu Gly Thr Val Pro Gly Asn 
            100                 105                 110         


Ala Leu Val Val Asp Pro Asp Lys Pro Phe Arg Lys Leu Asn Pro Phe 
        115                 120                 125             


Gly Asn Thr Phe Leu Asn Arg Phe Met Cys Ala Gln Leu Pro Asn Gln 
    130                 135                 140                 


Val Leu Glu Ser Ile Ser Ile Ile Asp Thr Pro Gly Ile Leu Ser Gly 
145                 150                 155                 160 


Ala Lys Gln Arg Val Ser Arg Gly Tyr Asp Phe Pro Ala Val Leu Arg 
                165                 170                 175     


Trp Phe Ala Glu Arg Val Asp Leu Ile Ile Leu Leu Phe Asp Ala His 
            180                 185                 190         


Lys Leu Glu Ile Ser Asp Glu Phe Ser Glu Ala Ile Gly Ala Leu Arg 
        195                 200                 205             


Gly His Glu Asp Lys Ile Arg Val Val Leu Asn Lys Ala Asp Met Val 
    210                 215                 220                 


Glu Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met Trp Ala Leu 
225                 230                 235                 240 


Gly Lys Val Val Gly Thr Pro Glu Val Leu Arg Val Tyr Ile Gly Ser 
                245                 250                 255     


Phe Trp Ser Gln Pro Leu Leu Val Pro Asp Asn Arg Arg Leu Phe Glu 
            260                 265                 270         


Leu Glu Glu Gln Asp Leu Phe Arg Asp Ile Gln Gly Leu Pro Arg His 
        275                 280                 285             


Ala Ala Leu Arg Lys Leu Asn Asp Leu Val Lys Arg Ala Arg Leu Val 
    290                 295                 300                 


Arg Val His Ala Tyr Ile Ile Ser Tyr Leu Lys Lys Glu Met Pro Ser 
305                 310                 315                 320 


Val Phe Gly Lys Glu Asn Lys Lys Lys Gln Leu Ile Leu Lys Leu Pro 
                325                 330                 335     


Val Ile Phe Ala Lys Ile Gln Leu Glu His His Ile Ser Pro Gly Asp 
            340                 345                 350         


Phe Pro Asp Cys Gln Lys Met Gln Glu Leu Leu Met Ala His Asp Phe 
        355                 360                 365             


Thr Lys Phe His Ser Leu Lys Pro Lys Leu Leu Glu Ala Leu Asp Glu 
    370                 375                 380                 


Met Leu Thr His Asp Ile Ala Lys Leu Met Pro Leu Leu Arg Gln Glu 
385                 390                 395                 400 


Glu Leu Glu Ser Thr Glu Val Gly Val Gln Gly Gly Ala Phe Glu Gly 
                405                 410                 415     


Thr His Met Gly Pro Phe Val Glu Arg Gly Pro Asp Glu Ala Met Glu 
            420                 425                 430         


Asp Gly Glu Glu Gly Ser Asp Asp Glu Ala Glu Trp Val Val Thr Lys 
        435                 440                 445             


Asp Lys Ser Lys Tyr Asp Glu Ile Phe Tyr Asn Leu Ala Pro Ala Asp 
    450                 455                 460                 


Gly Lys Leu Ser Gly Ser Lys Ala Lys Thr Trp Met Val Gly Thr Lys 
465                 470                 475                 480 


Leu Pro Asn Ser Val Leu Gly Arg Ile Trp Lys Leu Ser Asp Val Asp 
                485                 490                 495     


Arg Asp Gly Met Leu Asp Asp Glu Glu Phe Ala Leu Ala Ser His Leu 
            500                 505                 510         


Ile Glu Ala Lys Leu Glu Gly His Gly Leu Pro Ala Asn Leu Pro Arg 
        515                 520                 525             


Arg Leu Val Pro Pro Ser Lys Arg Arg His Lys Gly Ser Ala Glu 
    530                 535                 540             


<210>  3438
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHD3__Homo_sapiens__NP_055415

<400>  3438

Met Phe Ser Trp Leu Gly Thr Asp Asp Arg Arg Arg Lys Asp Pro Glu 
1               5                   10                  15      


Val Phe Gln Thr Val Ser Glu Gly Leu Lys Lys Leu Tyr Lys Ser Lys 
            20                  25                  30          


Leu Leu Pro Leu Glu Glu His Tyr Arg Phe His Glu Phe His Ser Pro 
        35                  40                  45              


Ala Leu Glu Asp Ala Asp Phe Asp Asn Lys Pro Met Val Leu Leu Val 
    50                  55                  60                  


Gly Gln Tyr Ser Thr Gly Lys Thr Thr Phe Ile Arg Tyr Leu Leu Glu 
65                  70                  75                  80  


Gln Asp Phe Pro Gly Met Arg Ile Gly Pro Glu Pro Thr Thr Asp Ser 
                85                  90                  95      


Phe Ile Ala Val Met Gln Gly Asp Met Glu Gly Ile Ile Pro Gly Asn 
            100                 105                 110         


Ala Leu Val Val Asp Pro Lys Lys Pro Phe Arg Lys Leu Asn Ala Phe 
        115                 120                 125             


Gly Asn Ala Phe Leu Asn Arg Phe Val Cys Ala Gln Leu Pro Asn Pro 
    130                 135                 140                 


Val Leu Glu Ser Ile Ser Val Ile Asp Thr Pro Gly Ile Leu Ser Gly 
145                 150                 155                 160 


Glu Lys Gln Arg Ile Ser Arg Gly Tyr Asp Phe Ala Ala Val Leu Glu 
                165                 170                 175     


Trp Phe Ala Glu Arg Val Asp Arg Ile Ile Leu Leu Phe Asp Ala His 
            180                 185                 190         


Lys Leu Asp Ile Ser Asp Glu Phe Ser Glu Val Ile Lys Ala Leu Lys 
        195                 200                 205             


Asn His Glu Asp Lys Met Arg Val Val Leu Asn Lys Ala Asp Gln Ile 
    210                 215                 220                 


Glu Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met Trp Ser Leu 
225                 230                 235                 240 


Gly Lys Ile Val Asn Thr Pro Glu Val Ile Arg Val Tyr Ile Gly Ser 
                245                 250                 255     


Phe Trp Ser His Pro Leu Leu Ile Pro Asp Asn Arg Lys Leu Phe Glu 
            260                 265                 270         


Ala Glu Glu Gln Asp Leu Phe Arg Asp Ile Gln Ser Leu Pro Arg Asn 
        275                 280                 285             


Ala Ala Leu Arg Lys Leu Asn Asp Leu Ile Lys Arg Ala Arg Leu Ala 
    290                 295                 300                 


Lys Val His Ala Tyr Ile Ile Ser Ser Leu Lys Lys Glu Met Pro Ser 
305                 310                 315                 320 


Val Phe Gly Lys Asp Asn Lys Lys Lys Glu Leu Val Asn Asn Leu Ala 
                325                 330                 335     


Glu Ile Tyr Gly Arg Ile Glu Arg Glu His Gln Ile Ser Pro Gly Asp 
            340                 345                 350         


Phe Pro Asn Leu Lys Arg Met Gln Asp Gln Leu Gln Ala Gln Asp Phe 
        355                 360                 365             


Ser Lys Phe Gln Pro Leu Lys Ser Lys Leu Leu Glu Val Val Asp Asp 
    370                 375                 380                 


Met Leu Ala His Asp Ile Ala Gln Leu Met Val Leu Val Arg Gln Glu 
385                 390                 395                 400 


Glu Ser Gln Arg Pro Ile Gln Met Val Lys Gly Gly Ala Phe Glu Gly 
                405                 410                 415     


Thr Leu His Gly Pro Phe Gly His Gly Tyr Gly Glu Gly Ala Gly Glu 
            420                 425                 430         


Gly Ile Asp Asp Ala Glu Trp Val Val Ala Arg Asp Lys Pro Met Tyr 
        435                 440                 445             


Asp Glu Ile Phe Tyr Thr Leu Ser Pro Val Asp Gly Lys Ile Thr Gly 
    450                 455                 460                 


Ala Asn Ala Lys Lys Glu Met Val Arg Ser Lys Leu Pro Asn Ser Val 
465                 470                 475                 480 


Leu Gly Lys Ile Trp Lys Leu Ala Asp Ile Asp Lys Asp Gly Met Leu 
                485                 490                 495     


Asp Asp Asp Glu Phe Ala Leu Ala Asn His Leu Ile Lys Val Lys Leu 
            500                 505                 510         


Glu Gly His Glu Leu Pro Asn Glu Leu Pro Ala His Leu Leu Pro Pro 
        515                 520                 525             


Ser Lys Arg Lys Val Ala Glu 
    530                 535 


<210>  3439
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHD4__Homo_sapiens__NP_644670

<400>  3439

Met Phe Ser Trp Met Gly Arg Gln Ala Gly Gly Arg Glu Arg Ala Gly 
1               5                   10                  15      


Gly Ala Asp Ala Val Gln Thr Val Thr Gly Gly Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Arg Lys Val Leu Pro Leu Glu Glu Ala Tyr Arg Phe His Glu Phe 
        35                  40                  45              


His Ser Pro Ala Leu Glu Asp Ala Asp Phe Glu Asn Lys Pro Met Ile 
    50                  55                  60                  


Leu Leu Val Gly Gln Tyr Ser Thr Gly Lys Thr Thr Phe Ile Arg Tyr 
65                  70                  75                  80  


Leu Leu Glu Gln Asp Phe Pro Gly Met Arg Ile Gly Pro Glu Pro Thr 
                85                  90                  95      


Thr Asp Ser Phe Ile Ala Val Met Tyr Gly Glu Thr Glu Gly Ser Thr 
            100                 105                 110         


Pro Gly Asn Ala Leu Val Val Asp Pro Lys Lys Pro Phe Arg Lys Leu 
        115                 120                 125             


Ser Arg Phe Gly Asn Ala Phe Leu Asn Arg Phe Met Cys Ser Gln Leu 
    130                 135                 140                 


Pro Asn Gln Val Leu Lys Ser Ile Ser Val Ile Asp Ser Pro Gly Ile 
145                 150                 155                 160 


Leu Ser Gly Glu Lys Gln Arg Ile Ser Arg Gly Tyr Asp Phe Cys Gln 
                165                 170                 175     


Val Leu Gln Trp Phe Ala Glu Arg Val Asp Arg Ile Ile Leu Leu Phe 
            180                 185                 190         


Asp Ala His Lys Leu Asp Ile Ser Asp Glu Phe Ser Glu Ala Ile Lys 
        195                 200                 205             


Ala Phe Arg Gly Gln Asp Asp Lys Ile Arg Val Val Leu Asn Lys Ala 
    210                 215                 220                 


Asp Gln Val Asp Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met 
225                 230                 235                 240 


Trp Ser Leu Gly Lys Val Ile Asn Thr Pro Glu Val Leu Arg Val Tyr 
                245                 250                 255     


Ile Gly Ser Phe Trp Ala Gln Pro Leu Gln Asn Thr Asp Asn Arg Arg 
            260                 265                 270         


Leu Phe Glu Ala Glu Ala Gln Asp Leu Phe Arg Asp Ile Gln Ser Leu 
        275                 280                 285             


Pro Gln Lys Ala Ala Val Arg Lys Leu Asn Asp Leu Ile Lys Arg Ala 
    290                 295                 300                 


Arg Leu Ala Lys Val His Ala Tyr Ile Ile Ser Tyr Leu Lys Lys Glu 
305                 310                 315                 320 


Met Pro Ser Val Phe Gly Lys Glu Asn Lys Lys Arg Glu Leu Ile Ser 
                325                 330                 335     


Arg Leu Pro Glu Ile Tyr Ile Gln Leu Gln Arg Glu Tyr Gln Ile Ser 
            340                 345                 350         


Ala Gly Asp Phe Pro Glu Val Lys Ala Met Gln Glu Gln Leu Glu Asn 
        355                 360                 365             


Tyr Asp Phe Thr Lys Phe His Ser Leu Lys Pro Lys Leu Ile Glu Ala 
    370                 375                 380                 


Val Asp Asn Met Leu Ser Asn Lys Ile Ser Pro Leu Met Asn Leu Ile 
385                 390                 395                 400 


Ser Gln Glu Glu Thr Ser Thr Pro Thr Gln Leu Val Gln Gly Gly Ala 
                405                 410                 415     


Phe Asp Gly Thr Thr Glu Gly Pro Phe Asn Gln Gly Tyr Gly Glu Gly 
            420                 425                 430         


Ala Lys Glu Gly Ala Asp Glu Glu Glu Trp Val Val Ala Lys Asp Lys 
        435                 440                 445             


Pro Val Tyr Asp Glu Leu Phe Tyr Thr Leu Ser Pro Ile Asn Gly Lys 
    450                 455                 460                 


Ile Ser Gly Val Asn Ala Lys Lys Glu Met Val Thr Ser Lys Leu Pro 
465                 470                 475                 480 


Asn Ser Val Leu Gly Lys Ile Trp Lys Leu Ala Asp Cys Asp Cys Asp 
                485                 490                 495     


Gly Met Leu Asp Glu Glu Glu Phe Ala Leu Ala Lys His Leu Ile Lys 
            500                 505                 510         


Ile Lys Leu Asp Gly Tyr Glu Leu Pro Ser Ser Leu Pro Pro His Leu 
        515                 520                 525             


Val Pro Pro Ser His Arg Lys Ser Leu Pro Lys Ala Asp 
    530                 535                 540     


<210>  3440
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHF__Homo_sapiens__NP_001193545

<400>  3440

Met Gly Leu Pro Glu Arg Arg Gly Leu Val Leu Leu Leu Ser Leu Ala 
1               5                   10                  15      


Glu Ile Leu Phe Lys Ile Met Ile Leu Glu Gly Gly Gly Val Met Asn 
            20                  25                  30          


Leu Asn Pro Gly Asn Asn Leu Leu His Gln Pro Pro Ala Trp Thr Asp 
        35                  40                  45              


Ser Tyr Ser Thr Cys Asn Val Ser Ser Gly Phe Phe Gly Gly Gln Trp 
    50                  55                  60                  


His Glu Ile His Pro Gln Tyr Trp Thr Lys Tyr Gln Val Trp Glu Trp 
65                  70                  75                  80  


Leu Gln His Leu Leu Asp Thr Asn Gln Leu Asp Ala Asn Cys Ile Pro 
                85                  90                  95      


Phe Gln Glu Phe Asp Ile Asn Gly Glu His Leu Cys Ser Met Ser Leu 
            100                 105                 110         


Gln Glu Phe Thr Arg Ala Ala Gly Thr Ala Gly Gln Leu Leu Tyr Ser 
        115                 120                 125             


Asn Leu Gln His Leu Lys Trp Asn Gly Gln Cys Ser Ser Asp Leu Phe 
    130                 135                 140                 


Gln Ser Thr His Asn Val Ile Val Lys Thr Glu Gln Thr Glu Pro Ser 
145                 150                 155                 160 


Ile Met Asn Thr Trp Lys Asp Glu Asn Tyr Leu Tyr Asp Thr Asn Tyr 
                165                 170                 175     


Gly Ser Thr Val Asp Leu Leu Asp Ser Lys Thr Phe Cys Arg Ala Gln 
            180                 185                 190         


Ile Ser Met Thr Thr Thr Ser His Leu Pro Val Ala Glu Ser Pro Asp 
        195                 200                 205             


Met Lys Lys Glu Gln Asp Pro Pro Ala Lys Cys His Thr Lys Lys His 
    210                 215                 220                 


Asn Pro Arg Gly Thr His Leu Trp Glu Phe Ile Arg Asp Ile Leu Leu 
225                 230                 235                 240 


Asn Pro Asp Lys Asn Pro Gly Leu Ile Lys Trp Glu Asp Arg Ser Glu 
                245                 250                 255     


Gly Val Phe Arg Phe Leu Lys Ser Glu Ala Val Ala Gln Leu Trp Gly 
            260                 265                 270         


Lys Lys Lys Asn Asn Ser Ser Met Thr Tyr Glu Lys Leu Ser Arg Ala 
        275                 280                 285             


Met Arg Tyr Tyr Tyr Lys Arg Glu Ile Leu Glu Arg Val Asp Gly Arg 
    290                 295                 300                 


Arg Leu Val Tyr Lys Phe Gly Lys Asn Ala Arg Gly Trp Arg Glu Asn 
305                 310                 315                 320 


Glu Asn 
        


<210>  3441
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHHADH__Homo_sapiens__NP_001159887

<400>  3441

Met Ala Phe Gly Gly Gly Leu Glu Leu Ala Leu Gly Cys His Tyr Arg 
1               5                   10                  15      


Ile Ala His Ala Glu Ala Gln Val Gly Leu Pro Glu Val Thr Leu Gly 
            20                  25                  30          


Leu Leu Pro Gly Ala Arg Gly Thr Gln Leu Leu Pro Arg Leu Thr Gly 
        35                  40                  45              


Val Pro Ala Ala Leu Asp Leu Ile Thr Ser Gly Arg Arg Ile Leu Ala 
    50                  55                  60                  


Asp Glu Ala Leu Lys Leu Gly Ile Leu Asp Lys Val Val Asn Ser Asp 
65                  70                  75                  80  


Pro Val Glu Glu Ala Ile Arg Phe Ala Gln Arg Val Ser Asp Gln Pro 
                85                  90                  95      


Leu Glu Ser Arg Arg Leu Cys Asn Lys Pro Ile Gln Ser Leu Pro Asn 
            100                 105                 110         


Met Asp Ser Ile Phe Ser Glu Ala Leu Leu Lys Met Arg Arg Gln His 
        115                 120                 125             


Pro Gly Cys Leu Ala Gln Glu Ala Cys Val Arg Ala Val Gln Ala Ala 
    130                 135                 140                 


Val Gln Tyr Pro Tyr Glu Val Gly Ile Lys Lys Glu Glu Glu Leu Phe 
145                 150                 155                 160 


Leu Tyr Leu Leu Gln Ser Gly Gln Ala Arg Ala Leu Gln Tyr Ala Phe 
                165                 170                 175     


Phe Ala Glu Arg Lys Ala Asn Lys Trp Ser Thr Pro Ser Gly Ala Ser 
            180                 185                 190         


Trp Lys Thr Ala Ser Ala Arg Pro Val Ser Ser Val Gly Val Val Gly 
        195                 200                 205             


Leu Gly Thr Met Gly Arg Gly Ile Val Ile Ser Phe Ala Arg Ala Arg 
    210                 215                 220                 


Ile Pro Val Ile Ala Val Asp Ser Asp Lys Asn Gln Leu Ala Thr Ala 
225                 230                 235                 240 


Asn Lys Met Ile Thr Ser Val Leu Glu Lys Glu Ala Ser Lys Met Gln 
                245                 250                 255     


Gln Ser Gly His Pro Trp Ser Gly Pro Lys Pro Arg Leu Thr Ser Ser 
            260                 265                 270         


Val Lys Glu Leu Gly Gly Val Asp Leu Val Ile Glu Ala Val Phe Glu 
        275                 280                 285             


Glu Met Ser Leu Lys Lys Gln Val Phe Ala Glu Leu Ser Ala Val Cys 
    290                 295                 300                 


Lys Pro Glu Ala Phe Leu Cys Thr Asn Thr Ser Ala Leu Asp Val Asp 
305                 310                 315                 320 


Glu Ile Ala Ser Ser Thr Asp Arg Pro His Leu Val Ile Gly Thr His 
                325                 330                 335     


Phe Phe Ser Pro Ala His Val Met Lys Leu Leu Glu Val Ile Pro Ser 
            340                 345                 350         


Gln Tyr Ser Ser Pro Thr Thr Ile Ala Thr Val Met Asn Leu Ser Lys 
        355                 360                 365             


Lys Ile Lys Lys Ile Gly Val Val Val Gly Asn Cys Phe Gly Phe Val 
    370                 375                 380                 


Gly Asn Arg Met Leu Asn Pro Tyr Tyr Asn Gln Ala Tyr Phe Leu Leu 
385                 390                 395                 400 


Glu Glu Gly Ser Lys Pro Glu Glu Val Asp Gln Val Leu Glu Glu Phe 
                405                 410                 415     


Gly Phe Lys Met Gly Pro Phe Arg Val Ser Asp Leu Ala Gly Leu Asp 
            420                 425                 430         


Val Gly Trp Lys Ser Arg Lys Gly Gln Gly Leu Thr Gly Pro Thr Leu 
        435                 440                 445             


Leu Pro Gly Thr Pro Ala Arg Lys Arg Gly Asn Arg Arg Tyr Cys Pro 
    450                 455                 460                 


Ile Pro Asp Val Leu Cys Glu Leu Gly Arg Phe Gly Gln Lys Thr Gly 
465                 470                 475                 480 


Lys Gly Trp Tyr Gln Tyr Asp Lys Pro Leu Gly Arg Ile His Lys Pro 
                485                 490                 495     


Asp Pro Trp Leu Ser Lys Phe Leu Ser Arg Tyr Arg Lys Thr His His 
            500                 505                 510         


Ile Glu Pro Arg Thr Ile Ser Gln Asp Glu Ile Leu Glu Arg Cys Leu 
        515                 520                 525             


Tyr Ser Leu Ile Asn Glu Ala Phe Arg Ile Leu Gly Glu Gly Ile Ala 
    530                 535                 540                 


Ala Ser Pro Glu His Ile Asp Val Val Tyr Leu His Gly Tyr Gly Trp 
545                 550                 555                 560 


Pro Arg His Lys Gly Gly Pro Met Phe Tyr Ala Ser Thr Val Gly Leu 
                565                 570                 575     


Pro Thr Val Leu Glu Lys Leu Gln Lys Tyr Tyr Arg Gln Asn Pro Asp 
            580                 585                 590         


Ile Pro Gln Leu Glu Pro Ser Asp Tyr Leu Lys Lys Leu Ala Ser Gln 
        595                 600                 605             


Gly Asn Pro Pro Leu Lys Glu Trp Gln Ser Leu Ala Gly Ser Pro Ser 
    610                 615                 620                 


Ser Lys Leu 
625         


<210>  3442
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHMT1__Homo_sapiens__NP_001138999

<400>  3442

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Phe Cys Arg Leu Gly Ser 
785                 790                 795                 800 


Pro Arg Ser Arg Gly Cys Leu Trp 
                805             


<210>  3443
<211>  1233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHMT2__Homo_sapiens__NP_001276342

<400>  3443

Met Arg Gly Leu Pro Arg Gly Arg Gly Leu Met Arg Ala Arg Gly Arg 
1               5                   10                  15      


Gly Arg Ala Ala Pro Pro Gly Ser Arg Gly Arg Gly Arg Gly Gly Pro 
            20                  25                  30          


His Arg Gly Arg Gly Arg Pro Arg Ser Leu Leu Ser Leu Pro Arg Ala 
        35                  40                  45              


Gln Ala Ser Trp Thr Pro Gln Leu Ser Thr Gly Leu Thr Ser Pro Pro 
    50                  55                  60                  


Val Pro Cys Leu Pro Ser Gln Gly Glu Ala Pro Ala Glu Met Gly Ala 
65                  70                  75                  80  


Leu Leu Leu Glu Lys Glu Thr Arg Gly Ala Thr Glu Arg Val His Gly 
                85                  90                  95      


Ser Leu Gly Asp Thr Pro Arg Ser Glu Glu Thr Leu Pro Lys Ala Thr 
            100                 105                 110         


Pro Asp Ser Leu Glu Pro Ala Gly Pro Ser Ser Pro Ala Ser Val Thr 
        115                 120                 125             


Val Thr Val Gly Asp Glu Gly Ala Asp Thr Pro Val Gly Ala Thr Pro 
    130                 135                 140                 


Leu Ile Gly Asp Glu Ser Glu Asn Leu Glu Gly Asp Gly Asp Leu Arg 
145                 150                 155                 160 


Gly Gly Arg Ile Leu Leu Gly His Ala Thr Lys Ser Phe Pro Ser Ser 
                165                 170                 175     


Pro Ser Lys Gly Gly Ser Cys Pro Ser Arg Ala Lys Met Ser Met Thr 
            180                 185                 190         


Gly Ala Gly Lys Ser Pro Pro Ser Val Gln Ser Leu Ala Met Arg Leu 
        195                 200                 205             


Leu Ser Met Pro Gly Ala Gln Gly Ala Ala Ala Ala Gly Ser Glu Pro 
    210                 215                 220                 


Pro Pro Ala Thr Thr Ser Pro Glu Gly Gln Pro Lys Val His Arg Ala 
225                 230                 235                 240 


Arg Lys Thr Met Ser Lys Pro Gly Asn Gly Gln Pro Pro Val Pro Glu 
                245                 250                 255     


Lys Arg Pro Pro Glu Ile Gln His Phe Arg Met Ser Asp Asp Val His 
            260                 265                 270         


Ser Leu Gly Lys Val Thr Ser Asp Leu Ala Lys Arg Arg Lys Leu Asn 
        275                 280                 285             


Ser Gly Gly Gly Leu Ser Glu Glu Leu Gly Ser Ala Arg Arg Ser Gly 
    290                 295                 300                 


Glu Val Thr Leu Thr Lys Gly Asp Pro Gly Ser Leu Glu Glu Trp Glu 
305                 310                 315                 320 


Thr Val Val Gly Asp Asp Phe Ser Leu Tyr Tyr Asp Ser Tyr Ser Val 
                325                 330                 335     


Asp Glu Arg Val Asp Ser Asp Ser Lys Ser Glu Val Glu Ala Leu Thr 
            340                 345                 350         


Glu Gln Leu Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Ser 
    370                 375                 380                 


Gly Asn Gln Ser Asp Arg Ser Gly Ser Ser Gly Arg Arg Lys Ala Lys 
385                 390                 395                 400 


Lys Lys Trp Arg Lys Asp Ser Pro Trp Val Lys Pro Ser Arg Lys Arg 
                405                 410                 415     


Arg Lys Arg Glu Pro Pro Arg Ala Lys Glu Pro Arg Gly Val Ser Asn 
            420                 425                 430         


Asp Thr Ser Ser Leu Glu Thr Glu Arg Gly Phe Glu Glu Leu Pro Leu 
        435                 440                 445             


Cys Ser Cys Arg Met Glu Ala Pro Lys Ile Asp Arg Ile Ser Glu Arg 
    450                 455                 460                 


Ala Gly His Lys Cys Met Ala Thr Glu Ser Val Asp Gly Glu Leu Ser 
465                 470                 475                 480 


Gly Cys Asn Ala Ala Ile Leu Lys Arg Glu Thr Met Arg Pro Ser Ser 
                485                 490                 495     


Arg Val Ala Leu Met Val Leu Cys Glu Thr His Arg Ala Arg Met Val 
            500                 505                 510         


Lys His His Cys Cys Pro Gly Cys Gly Tyr Phe Cys Thr Ala Gly Thr 
        515                 520                 525             


Phe Leu Glu Cys His Pro Asp Phe Arg Val Ala His Arg Phe His Lys 
    530                 535                 540                 


Ala Cys Val Ser Gln Leu Asn Gly Met Val Phe Cys Pro His Cys Gly 
545                 550                 555                 560 


Glu Asp Ala Ser Glu Ala Gln Glu Val Thr Ile Pro Arg Gly Asp Gly 
                565                 570                 575     


Val Thr Pro Pro Ala Gly Thr Ala Ala Pro Ala Pro Pro Pro Leu Ser 
            580                 585                 590         


Gln Asp Val Pro Gly Arg Ala Asp Thr Ser Gln Pro Ser Ala Arg Met 
        595                 600                 605             


Arg Gly His Gly Glu Pro Arg Arg Pro Pro Cys Asp Pro Leu Ala Asp 
    610                 615                 620                 


Thr Ile Asp Ser Ser Gly Pro Ser Leu Thr Leu Pro Asn Gly Gly Cys 
625                 630                 635                 640 


Leu Ser Ala Val Gly Leu Pro Leu Gly Pro Gly Arg Glu Ala Leu Glu 
                645                 650                 655     


Lys Ala Leu Val Ile Gln Glu Ser Glu Arg Arg Lys Lys Leu Arg Phe 
            660                 665                 670         


His Pro Arg Gln Leu Tyr Leu Ser Val Lys Gln Gly Glu Leu Gln Lys 
        675                 680                 685             


Val Ile Leu Met Leu Leu Asp Asn Leu Asp Pro Asn Phe Gln Ser Asp 
    690                 695                 700                 


Gln Gln Ser Lys Arg Thr Pro Leu His Ala Ala Ala Gln Lys Gly Ser 
705                 710                 715                 720 


Val Glu Ile Cys His Val Leu Leu Gln Ala Gly Ala Asn Ile Asn Ala 
                725                 730                 735     


Val Asp Lys Gln Gln Arg Thr Pro Leu Met Glu Ala Val Val Asn Asn 
            740                 745                 750         


His Leu Glu Val Ala Arg Tyr Met Val Gln Arg Gly Gly Cys Val Tyr 
        755                 760                 765             


Ser Lys Glu Glu Asp Gly Ser Thr Cys Leu His His Ala Ala Lys Ile 
    770                 775                 780                 


Gly Asn Leu Glu Met Val Ser Leu Leu Leu Ser Thr Gly Gln Val Asp 
785                 790                 795                 800 


Val Asn Ala Gln Asp Ser Gly Gly Trp Thr Pro Ile Ile Trp Ala Ala 
                805                 810                 815     


Glu His Lys His Ile Glu Val Ile Arg Met Leu Leu Thr Arg Gly Ala 
            820                 825                 830         


Asp Val Thr Leu Thr Asp Asn Glu Glu Asn Ile Cys Leu His Trp Ala 
        835                 840                 845             


Ser Phe Thr Gly Ser Ala Ala Ile Ala Glu Val Leu Leu Asn Ala Arg 
    850                 855                 860                 


Cys Asp Leu His Ala Val Asn Tyr His Gly Asp Thr Pro Leu His Ile 
865                 870                 875                 880 


Ala Ala Arg Glu Ser Tyr His Asp Cys Val Leu Leu Phe Leu Ser Arg 
                885                 890                 895     


Gly Ala Asn Pro Glu Leu Arg Asn Lys Glu Gly Asp Thr Ala Trp Asp 
            900                 905                 910         


Leu Thr Pro Glu Arg Ser Asp Val Trp Phe Ala Leu Gln Leu Asn Arg 
        915                 920                 925             


Lys Leu Arg Leu Gly Val Gly Asn Arg Ala Ile Arg Thr Glu Lys Ile 
    930                 935                 940                 


Ile Cys Arg Asp Val Ala Arg Gly Tyr Glu Asn Val Pro Ile Pro Cys 
945                 950                 955                 960 


Val Asn Gly Val Asp Gly Glu Pro Cys Pro Glu Asp Tyr Lys Tyr Ile 
                965                 970                 975     


Ser Glu Asn Cys Glu Thr Ser Thr Met Asn Ile Asp Arg Asn Ile Thr 
            980                 985                 990         


His Leu Gln His Cys Thr Cys Val  Asp Asp Cys Ser Ser  Ser Asn Cys 
        995                 1000                 1005             


Leu Cys  Gly Gln Leu Ser Ile  Arg Cys Trp Tyr Asp  Lys Asp Gly 
    1010                 1015                 1020             


Arg Leu  Leu Gln Glu Phe Asn  Lys Ile Glu Pro Pro  Leu Ile Phe 
    1025                 1030                 1035             


Glu Cys  Asn Gln Ala Cys Ser  Cys Trp Arg Asn Cys  Lys Asn Arg 
    1040                 1045                 1050             


Val Val  Gln Ser Gly Ile Lys  Val Arg Leu Gln Leu  Tyr Arg Thr 
    1055                 1060                 1065             


Ala Lys  Met Gly Trp Gly Val  Arg Ala Leu Gln Thr  Ile Pro Gln 
    1070                 1075                 1080             


Gly Thr  Phe Ile Cys Glu Tyr  Val Gly Glu Leu Ile  Ser Asp Ala 
    1085                 1090                 1095             


Glu Ala  Asp Val Arg Glu Asp  Asp Ser Tyr Leu Phe  Asp Leu Asp 
    1100                 1105                 1110             


Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp Ala Arg  Tyr Tyr Gly 
    1115                 1120                 1125             


Asn Ile  Ser Arg Phe Ile Asn  His Leu Cys Asp Pro  Asn Ile Ile 
    1130                 1135                 1140             


Pro Val  Arg Val Phe Met Leu  His Gln Asp Leu Arg  Phe Pro Arg 
    1145                 1150                 1155             


Ile Ala  Phe Phe Ser Ser Arg  Asp Ile Arg Thr Gly  Glu Glu Leu 
    1160                 1165                 1170             


Gly Phe  Asp Tyr Gly Asp Arg  Phe Trp Asp Ile Lys  Ser Lys Tyr 
    1175                 1180                 1185             


Phe Thr  Cys Gln Cys Gly Ser  Glu Lys Cys Lys His  Ser Ala Glu 
    1190                 1195                 1200             


Ala Ile  Ala Leu Glu Gln Ser  Arg Leu Ala Arg Leu  Asp Pro His 
    1205                 1210                 1215             


Pro Glu  Leu Leu Pro Glu Leu  Gly Ser Leu Pro Pro  Val Asn Thr 
    1220                 1225                 1230             


<210>  3444
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EI24__Homo_sapiens__XP_011541371

<400>  3444

Met Ala Asp Ser Val Lys Thr Phe Leu Gln Asp Leu Ala Arg Gly Ile 
1               5                   10                  15      


Lys Asp Ser Ile Trp Gly Ile Cys Thr Ile Ser Lys Leu Asp Ala Arg 
            20                  25                  30          


Ile Gln Gln Lys Arg Glu Glu Gln Arg Arg Arg Arg Ala Ser Ser Val 
        35                  40                  45              


Leu Ala Gln Arg Arg Ala Gln Ser Ile Glu Arg Lys Gln Glu Ser Glu 
    50                  55                  60                  


Pro Arg Ile Val Ser Arg Ile Phe Gln Cys Cys Ala Trp Asn Gly Gly 
65                  70                  75                  80  


Val Phe Trp Phe Ser Leu Leu Leu Phe Tyr Arg Val Phe Ile Pro Val 
                85                  90                  95      


Leu Gln Ser Val Thr Ala Arg Ile Ile Gly Asp Pro Ser Leu His Gly 
            100                 105                 110         


Asp Val Trp Ser Trp Leu Glu Phe Phe Leu Thr Ser Ile Phe Ser Ala 
        115                 120                 125             


Leu Trp Val Leu Pro Leu Phe Val Leu Ser Lys Val Val Asn Ala Ile 
    130                 135                 140                 


Trp Phe Gln Asp Ile Ala Asp Leu Ala Phe Glu Val Ser Gly Arg Lys 
145                 150                 155                 160 


Pro His Pro Phe Pro Ser Val Ser Lys Ile Ile Ala Asp Met Leu Phe 
                165                 170                 175     


Asn Leu Leu Leu Gln Ala Leu Phe Leu Ile Gln Gly Met Phe Val Ser 
            180                 185                 190         


Leu Phe Pro Ile His Leu Val Gly Gln Leu Val Ser Leu Leu His Met 
        195                 200                 205             


Ser Leu Leu Tyr Ser Leu Tyr Cys Phe Glu Tyr Arg Trp Phe Asn Lys 
    210                 215                 220                 


Gly Ile Glu Met His Gln Arg Leu Ser Asn Ile Glu Arg Asn Trp Pro 
225                 230                 235                 240 


Tyr Tyr Phe Gly Phe Gly Leu Pro Leu Ala Phe Leu Thr Ala Met Gln 
                245                 250                 255     


Ser Ser Tyr Ile Ile Ser Gly Cys Leu Phe Ser Ile Leu Phe Pro Leu 
            260                 265                 270         


Phe Ile Ile Ser Ala Asn Glu Ala Lys Thr Pro Gly Lys Ala Tyr Leu 
        275                 280                 285             


Phe Gln Leu Arg Leu Phe Ser Leu Val Val Phe Leu Ser Asn Arg Leu 
    290                 295                 300                 


Phe His Lys Thr Val Tyr Leu Gln Ser Ala Leu Ser Ser Ser Thr Ser 
305                 310                 315                 320 


Ala Glu Lys Phe Pro Ser Pro His Pro Ser Pro Ala Lys Leu Lys Ala 
                325                 330                 335     


Thr Ala Gly His 
            340 


<210>  3445
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EID1__Homo_sapiens__NP_055150

<400>  3445

Met Ser Glu Met Ala Glu Leu Ser Glu Leu Tyr Glu Glu Ser Ser Asp 
1               5                   10                  15      


Leu Gln Met Asp Val Met Pro Gly Glu Gly Asp Leu Pro Gln Met Glu 
            20                  25                  30          


Val Gly Ser Gly Ser Arg Glu Leu Ser Leu Arg Pro Ser Arg Ser Gly 
        35                  40                  45              


Ala Gln Gln Leu Glu Glu Glu Gly Pro Met Glu Glu Glu Glu Ala Gln 
    50                  55                  60                  


Pro Met Ala Ala Pro Glu Gly Lys Arg Ser Leu Ala Asn Gly Pro Asn 
65                  70                  75                  80  


Ala Gly Glu Gln Pro Gly Gln Val Ala Gly Ala Asp Phe Glu Ser Glu 
                85                  90                  95      


Asp Glu Gly Glu Glu Phe Asp Asp Trp Glu Asp Asp Tyr Asp Tyr Pro 
            100                 105                 110         


Glu Glu Glu Gln Leu Ser Gly Ala Gly Tyr Arg Val Ser Ala Ala Leu 
        115                 120                 125             


Glu Glu Ala Asp Lys Met Phe Leu Arg Thr Arg Glu Pro Ala Leu Asp 
    130                 135                 140                 


Gly Gly Phe Gln Met His Tyr Glu Lys Thr Pro Phe Asp Gln Leu Ala 
145                 150                 155                 160 


Phe Ile Glu Glu Leu Phe Ser Leu Met Val Val Asn Arg Leu Thr Glu 
                165                 170                 175     


Glu Leu Gly Cys Asp Glu Ile Ile Asp Arg Glu 
            180                 185         


<210>  3446
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF1AD__Homo_sapiens__NP_001229411

<400>  3446

Met Ser Gln Ala Thr Lys Arg Lys His Val Val Lys Glu Val Leu Gly 
1               5                   10                  15      


Glu His Ile Val Pro Ser Asp Gln Gln Gln Ile Val Arg Val Leu Arg 
            20                  25                  30          


Thr Pro Gly Asn Asn Leu His Glu Val Glu Thr Ala Gln Gly Gln Arg 
        35                  40                  45              


Phe Leu Val Ser Met Pro Ser Lys Tyr Arg Lys Asn Ile Trp Ile Lys 
    50                  55                  60                  


Arg Gly Asp Phe Leu Ile Val Asp Pro Ile Glu Glu Gly Glu Lys Val 
65                  70                  75                  80  


Lys Ala Glu Ile Ser Phe Val Leu Cys Lys Asp His Val Arg Ser Leu 
                85                  90                  95      


Gln Lys Glu Gly Phe Trp Pro Glu Ala Phe Ser Glu Val Ala Glu Lys 
            100                 105                 110         


His Asn Asn Arg Asn Arg Gln Thr Gln Pro Glu Leu Pro Ala Glu Pro 
        115                 120                 125             


Gln Leu Ser Gly Glu Glu Ser Ser Ser Glu Asp Asp Ser Asp Leu Phe 
    130                 135                 140                 


Val Asn Thr Asn Arg Arg Gln Tyr His Glu Ser Glu Glu Glu Ser Glu 
145                 150                 155                 160 


Glu Glu Glu Ala Ala 
                165 


<210>  3447
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF1AX__Homo_sapiens__NP_001403

<400>  3447

Met Pro Lys Asn Lys Gly Lys Gly Gly Lys Asn Arg Arg Arg Gly Lys 
1               5                   10                  15      


Asn Glu Asn Glu Ser Glu Lys Arg Glu Leu Val Phe Lys Glu Asp Gly 
            20                  25                  30          


Gln Glu Tyr Ala Gln Val Ile Lys Met Leu Gly Asn Gly Arg Leu Glu 
        35                  40                  45              


Ala Met Cys Phe Asp Gly Val Lys Arg Leu Cys His Ile Arg Gly Lys 
    50                  55                  60                  


Leu Arg Lys Lys Val Trp Ile Asn Thr Ser Asp Ile Ile Leu Val Gly 
65                  70                  75                  80  


Leu Arg Asp Tyr Gln Asp Asn Lys Ala Asp Val Ile Leu Lys Tyr Asn 
                85                  90                  95      


Ala Asp Glu Ala Arg Ser Leu Lys Ala Tyr Gly Glu Leu Pro Glu His 
            100                 105                 110         


Ala Lys Ile Asn Glu Thr Asp Thr Phe Gly Pro Gly Asp Asp Asp Glu 
        115                 120                 125             


Ile Gln Phe Asp Asp Ile Gly Asp Asp Asp Glu Asp Ile Asp Asp Ile 
    130                 135                 140                 


<210>  3448
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF1AY__Homo_sapiens__NP_001265541

<400>  3448

Met Pro Lys Asn Lys Gly Lys Gly Gly Lys Asn Arg Arg Arg Gly Lys 
1               5                   10                  15      


Asn Glu Asn Glu Ser Glu Lys Arg Glu Leu Val Phe Lys Glu Asp Gly 
            20                  25                  30          


Gln Glu Tyr Ala Gln Val Ile Lys Met Leu Gly Asn Gly Arg Leu Glu 
        35                  40                  45              


Ala Leu Cys Phe Asp Gly Val Lys Arg Leu Cys His Ile Arg Gly Lys 
    50                  55                  60                  


Leu Arg Lys Lys Asp Asn Lys Ala Asp Val Ile Leu Lys Tyr Asn Ala 
65                  70                  75                  80  


Asp Glu Ala Arg Ser Leu Lys Ala Tyr Gly Glu Leu Pro Glu His Ala 
                85                  90                  95      


Lys Ile Asn Glu Thr Asp Thr Phe Gly Pro Gly Asp Asp Asp Glu Ile 
            100                 105                 110         


Gln Phe Asp Asp Ile Gly Asp Asp Asp Glu Asp Ile Asp Asp Ile 
        115                 120                 125         


<210>  3449
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF1__Homo_sapiens__NP_005792

<400>  3449

Met Ser Ala Ile Gln Asn Leu His Ser Phe Asp Pro Phe Ala Asp Ala 
1               5                   10                  15      


Ser Lys Gly Asp Asp Leu Leu Pro Ala Gly Thr Glu Asp Tyr Ile His 
            20                  25                  30          


Ile Arg Ile Gln Gln Arg Asn Gly Arg Lys Thr Leu Thr Thr Val Gln 
        35                  40                  45              


Gly Ile Ala Asp Asp Tyr Asp Lys Lys Lys Leu Val Lys Ala Phe Lys 
    50                  55                  60                  


Lys Lys Phe Ala Cys Asn Gly Thr Val Ile Glu His Pro Glu Tyr Gly 
65                  70                  75                  80  


Glu Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Ile Cys Gln Phe 
                85                  90                  95      


Leu Val Glu Ile Gly Leu Ala Lys Asp Asp Gln Leu Lys Val His Gly 
            100                 105                 110         


Phe 
    


<210>  3450
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2A__Homo_sapiens__NP_114414

<400>  3450

Met Ala Pro Ser Thr Pro Leu Leu Thr Val Arg Gly Ser Glu Gly Leu 
1               5                   10                  15      


Tyr Met Val Asn Gly Pro Pro His Phe Thr Glu Ser Thr Val Phe Pro 
            20                  25                  30          


Arg Glu Ser Gly Lys Asn Cys Lys Val Cys Ile Phe Ser Lys Asp Gly 
        35                  40                  45              


Thr Leu Phe Ala Trp Gly Asn Gly Glu Lys Val Asn Ile Ile Ser Val 
    50                  55                  60                  


Thr Asn Lys Gly Leu Leu His Ser Phe Asp Leu Leu Lys Ala Val Cys 
65                  70                  75                  80  


Leu Glu Phe Ser Pro Lys Asn Thr Val Leu Ala Thr Trp Gln Pro Tyr 
                85                  90                  95      


Thr Thr Ser Lys Asp Gly Thr Ala Gly Ile Pro Asn Leu Gln Leu Tyr 
            100                 105                 110         


Asp Val Lys Thr Gly Thr Cys Leu Lys Ser Phe Ile Gln Lys Lys Met 
        115                 120                 125             


Gln Asn Trp Cys Pro Ser Trp Ser Glu Asp Glu Thr Leu Cys Ala Arg 
    130                 135                 140                 


Asn Val Asn Asn Glu Val His Phe Phe Glu Asn Asn Asn Phe Asn Thr 
145                 150                 155                 160 


Ile Ala Asn Lys Leu His Leu Gln Lys Ile Asn Asp Phe Val Leu Ser 
                165                 170                 175     


Pro Gly Pro Gln Pro Tyr Lys Val Ala Val Tyr Val Pro Gly Ser Lys 
            180                 185                 190         


Gly Ala Pro Ser Phe Val Arg Leu Tyr Gln Tyr Pro Asn Phe Ala Gly 
        195                 200                 205             


Pro His Ala Ala Leu Ala Asn Lys Ser Phe Phe Lys Ala Asp Lys Val 
    210                 215                 220                 


Thr Met Leu Trp Asn Lys Lys Ala Thr Ala Val Leu Val Ile Ala Ser 
225                 230                 235                 240 


Thr Asp Val Asp Lys Thr Gly Ala Ser Tyr Tyr Gly Glu Gln Thr Leu 
                245                 250                 255     


His Tyr Ile Ala Thr Asn Gly Glu Ser Ala Val Val Gln Leu Pro Lys 
            260                 265                 270         


Asn Gly Pro Ile Tyr Asp Val Val Trp Asn Ser Ser Ser Thr Glu Phe 
        275                 280                 285             


Cys Ala Val Tyr Gly Phe Met Pro Ala Lys Ala Thr Ile Phe Asn Leu 
    290                 295                 300                 


Lys Cys Asp Pro Val Phe Asp Phe Gly Thr Gly Pro Arg Asn Ala Ala 
305                 310                 315                 320 


Tyr Tyr Ser Pro His Gly His Ile Leu Val Leu Ala Gly Phe Gly Asn 
                325                 330                 335     


Leu Arg Gly Gln Met Glu Val Trp Asp Val Lys Asn Tyr Lys Leu Ile 
            340                 345                 350         


Ser Lys Pro Val Ala Ser Asp Ser Thr Tyr Phe Ala Trp Cys Pro Asp 
        355                 360                 365             


Gly Glu His Ile Leu Thr Ala Thr Cys Ala Pro Arg Leu Arg Val Asn 
    370                 375                 380                 


Asn Gly Tyr Lys Ile Trp His Tyr Thr Gly Ser Ile Leu His Lys Tyr 
385                 390                 395                 400 


Asp Val Pro Ser Asn Ala Glu Leu Trp Gln Val Ser Trp Gln Pro Phe 
                405                 410                 415     


Leu Asp Gly Ile Phe Pro Ala Lys Thr Ile Thr Tyr Gln Ala Val Pro 
            420                 425                 430         


Ser Glu Val Pro Asn Glu Glu Pro Lys Val Ala Thr Ala Tyr Arg Pro 
        435                 440                 445             


Pro Ala Leu Arg Asn Lys Pro Ile Thr Asn Ser Lys Leu His Glu Glu 
    450                 455                 460                 


Glu Pro Pro Gln Asn Met Lys Pro Gln Ser Gly Asn Asp Lys Pro Leu 
465                 470                 475                 480 


Ser Lys Thr Ala Leu Lys Asn Gln Arg Lys His Glu Ala Lys Lys Ala 
                485                 490                 495     


Ala Lys Gln Glu Ala Arg Ser Asp Lys Ser Pro Asp Leu Ala Pro Thr 
            500                 505                 510         


Pro Ala Pro Gln Ser Thr Pro Arg Asn Thr Val Ser Gln Ser Ile Ser 
        515                 520                 525             


Gly Asp Pro Glu Ile Asp Lys Lys Ile Lys Asn Leu Lys Lys Lys Leu 
    530                 535                 540                 


Lys Ala Ile Glu Gln Leu Lys Glu Gln Ala Ala Thr Gly Lys Gln Leu 
545                 550                 555                 560 


Glu Lys Asn Gln Leu Glu Lys Ile Gln Lys Glu Thr Ala Leu Leu Gln 
                565                 570                 575     


Glu Leu Glu Asp Leu Glu Leu Gly Ile 
            580                 585 


<210>  3451
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2AK1__Homo_sapiens__NP_055228

<400>  3451

Met Gln Gly Gly Asn Ser Gly Val Arg Lys Arg Glu Glu Glu Gly Asp 
1               5                   10                  15      


Gly Ala Gly Ala Val Ala Ala Pro Pro Ala Ile Asp Phe Pro Ala Glu 
            20                  25                  30          


Gly Pro Asp Pro Glu Tyr Asp Glu Ser Asp Val Pro Ala Glu Ile Gln 
        35                  40                  45              


Val Leu Lys Glu Pro Leu Gln Gln Pro Thr Phe Pro Phe Ala Val Ala 
    50                  55                  60                  


Asn Gln Leu Leu Leu Val Ser Leu Leu Glu His Leu Ser His Val His 
65                  70                  75                  80  


Glu Pro Asn Pro Leu Arg Ser Arg Gln Val Phe Lys Leu Leu Cys Gln 
                85                  90                  95      


Thr Phe Ile Lys Met Gly Leu Leu Ser Ser Phe Thr Cys Ser Asp Glu 
            100                 105                 110         


Phe Ser Ser Leu Arg Leu His His Asn Arg Ala Ile Thr His Leu Met 
        115                 120                 125             


Arg Ser Ala Lys Glu Arg Val Arg Gln Asp Pro Cys Glu Asp Ile Ser 
    130                 135                 140                 


Arg Ile Gln Lys Ile Arg Ser Arg Glu Val Ala Leu Glu Ala Gln Thr 
145                 150                 155                 160 


Ser Arg Tyr Leu Asn Glu Phe Glu Glu Leu Ala Ile Leu Gly Lys Gly 
                165                 170                 175     


Gly Tyr Gly Arg Val Tyr Lys Val Arg Asn Lys Leu Asp Gly Gln Tyr 
            180                 185                 190         


Tyr Ala Ile Lys Lys Ile Leu Ile Lys Gly Ala Thr Lys Thr Val Cys 
        195                 200                 205             


Met Lys Val Leu Arg Glu Val Lys Val Leu Ala Gly Leu Gln His Pro 
    210                 215                 220                 


Asn Ile Val Gly Tyr His Thr Ala Trp Ile Glu His Val His Val Ile 
225                 230                 235                 240 


Gln Pro Arg Ala Asp Arg Ala Ala Ile Glu Leu Pro Ser Leu Glu Val 
                245                 250                 255     


Leu Ser Asp Gln Glu Glu Asp Arg Glu Gln Cys Gly Val Lys Asn Asp 
            260                 265                 270         


Glu Ser Ser Ser Ser Ser Ile Ile Phe Ala Glu Pro Thr Pro Glu Lys 
        275                 280                 285             


Glu Lys Arg Phe Gly Glu Ser Asp Thr Glu Asn Gln Asn Asn Lys Ser 
    290                 295                 300                 


Val Lys Tyr Thr Thr Asn Leu Val Ile Arg Glu Ser Gly Glu Leu Glu 
305                 310                 315                 320 


Ser Thr Leu Glu Leu Gln Glu Asn Gly Leu Ala Gly Leu Ser Ala Ser 
                325                 330                 335     


Ser Ile Val Glu Gln Gln Leu Pro Leu Arg Arg Asn Ser His Leu Glu 
            340                 345                 350         


Glu Ser Phe Thr Ser Thr Glu Glu Ser Ser Glu Glu Asn Val Asn Phe 
        355                 360                 365             


Leu Gly Gln Thr Glu Ala Gln Tyr His Leu Met Leu His Ile Gln Met 
    370                 375                 380                 


Gln Leu Cys Glu Leu Ser Leu Trp Asp Trp Ile Val Glu Arg Asn Lys 
385                 390                 395                 400 


Arg Gly Arg Glu Tyr Val Asp Glu Ser Ala Cys Pro Tyr Val Met Ala 
                405                 410                 415     


Asn Val Ala Thr Lys Ile Phe Gln Glu Leu Val Glu Gly Val Phe Tyr 
            420                 425                 430         


Ile His Asn Met Gly Ile Val His Arg Asp Leu Lys Pro Arg Asn Ile 
        435                 440                 445             


Phe Leu His Gly Pro Asp Gln Gln Val Lys Ile Gly Asp Phe Gly Leu 
    450                 455                 460                 


Ala Cys Thr Asp Ile Leu Gln Lys Asn Thr Asp Trp Thr Asn Arg Asn 
465                 470                 475                 480 


Gly Lys Arg Thr Pro Thr His Thr Ser Arg Val Gly Thr Cys Leu Tyr 
                485                 490                 495     


Ala Ser Pro Glu Gln Leu Glu Gly Ser Glu Tyr Asp Ala Lys Ser Asp 
            500                 505                 510         


Met Tyr Ser Leu Gly Val Val Leu Leu Glu Leu Phe Gln Pro Phe Gly 
        515                 520                 525             


Thr Glu Met Glu Arg Ala Glu Val Leu Thr Gly Leu Arg Thr Gly Gln 
    530                 535                 540                 


Leu Pro Glu Ser Leu Arg Lys Arg Cys Pro Val Gln Ala Lys Tyr Ile 
545                 550                 555                 560 


Gln His Leu Thr Arg Arg Asn Ser Ser Gln Arg Pro Ser Ala Ile Gln 
                565                 570                 575     


Leu Leu Gln Ser Glu Leu Phe Gln Asn Ser Gly Asn Val Asn Leu Thr 
            580                 585                 590         


Leu Gln Met Lys Ile Ile Glu Gln Glu Lys Glu Ile Ala Glu Leu Lys 
        595                 600                 605             


Lys Gln Leu Asn Leu Leu Ser Gln Asp Lys Gly Val Arg Asp Asp Gly 
    610                 615                 620                 


Lys Asp Gly Gly Val Gly 
625                 630 


<210>  3452
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2AK2__Homo_sapiens__NP_001129124

<400>  3452

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Lys Ala Glu Arg Glu Val Lys Ala Leu Ala 
            260                 265                 270         


Lys Leu Asp His Val Asn Ile Val His Tyr Asn Gly Cys Trp Asp Gly 
        275                 280                 285             


Phe Asp Tyr Asp Pro Glu Thr Ser Asp Asp Ser Leu Glu Ser Ser Asp 
    290                 295                 300                 


Tyr Asp Pro Glu Asn Ser Lys Asn Ser Ser Arg Ser Lys Thr Lys Cys 
305                 310                 315                 320 


Leu Phe Ile Gln Met Glu Phe Cys Asp Lys Gly Thr Leu Glu Gln Trp 
                325                 330                 335     


Ile Glu Lys Arg Arg Gly Glu Lys Leu Asp Lys Val Leu Ala Leu Glu 
            340                 345                 350         


Leu Phe Glu Gln Ile Thr Lys Gly Val Asp Tyr Ile His Ser Lys Lys 
        355                 360                 365             


Leu Ile His Arg Asp Leu Lys Pro Ser Asn Ile Phe Leu Val Asp Thr 
    370                 375                 380                 


Lys Gln Val Lys Ile Gly Asp Phe Gly Leu Val Thr Ser Leu Lys Asn 
385                 390                 395                 400 


Asp Gly Lys Arg Thr Arg Ser Lys Gly Thr Leu Arg Tyr Met Ser Pro 
                405                 410                 415     


Glu Gln Ile Ser Ser Gln Asp Tyr Gly Lys Glu Val Asp Leu Tyr Ala 
            420                 425                 430         


Leu Gly Leu Ile Leu Ala Glu Leu Leu His Val Cys Asp Thr Ala Phe 
        435                 440                 445             


Glu Thr Ser Lys Phe Phe Thr Asp Leu Arg Asp Gly Ile Ile Ser Asp 
    450                 455                 460                 


Ile Phe Asp Lys Lys Glu Lys Thr Leu Leu Gln Lys Leu Leu Ser Lys 
465                 470                 475                 480 


Lys Pro Glu Asp Arg Pro Asn Thr Ser Glu Ile Leu Arg Thr Leu Thr 
                485                 490                 495     


Val Trp Lys Lys Ser Pro Glu Lys Asn Glu Arg His Thr Cys 
            500                 505                 510 


<210>  3453
<211>  1116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2AK3__Homo_sapiens__NP_004827

<400>  3453

Met Glu Arg Ala Ile Ser Pro Gly Leu Leu Val Arg Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Leu Ala Ala Arg Thr Val Ala Ala Gly Arg 
            20                  25                  30          


Ala Arg Gly Leu Pro Ala Pro Thr Ala Glu Ala Ala Phe Gly Leu Gly 
        35                  40                  45              


Ala Ala Ala Ala Pro Thr Ser Ala Thr Arg Val Pro Ala Ala Gly Ala 
    50                  55                  60                  


Val Ala Ala Ala Glu Val Thr Val Glu Asp Ala Glu Ala Leu Pro Ala 
65                  70                  75                  80  


Ala Ala Gly Glu Gln Glu Pro Arg Gly Pro Glu Pro Asp Asp Glu Thr 
                85                  90                  95      


Glu Leu Arg Pro Arg Gly Arg Ser Leu Val Ile Ile Ser Thr Leu Asp 
            100                 105                 110         


Gly Arg Ile Ala Ala Leu Asp Pro Glu Asn His Gly Lys Lys Gln Trp 
        115                 120                 125             


Asp Leu Asp Val Gly Ser Gly Ser Leu Val Ser Ser Ser Leu Ser Lys 
    130                 135                 140                 


Pro Glu Val Phe Gly Asn Lys Met Ile Ile Pro Ser Leu Asp Gly Ala 
145                 150                 155                 160 


Leu Phe Gln Trp Asp Gln Asp Arg Glu Ser Met Glu Thr Val Pro Phe 
                165                 170                 175     


Thr Val Glu Ser Leu Leu Glu Ser Ser Tyr Lys Phe Gly Asp Asp Val 
            180                 185                 190         


Val Leu Val Gly Gly Lys Ser Leu Thr Thr Tyr Gly Leu Ser Ala Tyr 
        195                 200                 205             


Ser Gly Lys Val Arg Tyr Ile Cys Ser Ala Leu Gly Cys Arg Gln Trp 
    210                 215                 220                 


Asp Ser Asp Glu Met Glu Gln Glu Glu Asp Ile Leu Leu Leu Gln Arg 
225                 230                 235                 240 


Thr Gln Lys Thr Val Arg Ala Val Gly Pro Arg Ser Gly Asn Glu Lys 
                245                 250                 255     


Trp Asn Phe Ser Val Gly His Phe Glu Leu Arg Tyr Ile Pro Asp Met 
            260                 265                 270         


Glu Thr Arg Ala Gly Phe Ile Glu Ser Thr Phe Lys Pro Asn Glu Asn 
        275                 280                 285             


Thr Glu Glu Ser Lys Ile Ile Ser Asp Val Glu Glu Gln Glu Ala Ala 
    290                 295                 300                 


Ile Met Asp Ile Val Ile Lys Val Ser Val Ala Asp Trp Lys Val Met 
305                 310                 315                 320 


Ala Phe Ser Lys Lys Gly Gly His Leu Glu Trp Glu Tyr Gln Phe Cys 
                325                 330                 335     


Thr Pro Ile Ala Ser Ala Trp Leu Leu Lys Asp Gly Lys Val Ile Pro 
            340                 345                 350         


Ile Ser Leu Phe Asp Asp Thr Ser Tyr Thr Ser Asn Asp Asp Val Leu 
        355                 360                 365             


Glu Asp Glu Glu Asp Ile Val Glu Ala Ala Arg Gly Ala Thr Glu Asn 
    370                 375                 380                 


Ser Val Tyr Leu Gly Met Tyr Arg Gly Gln Leu Tyr Leu Gln Ser Ser 
385                 390                 395                 400 


Val Arg Ile Ser Glu Lys Phe Pro Ser Ser Pro Lys Ala Leu Glu Ser 
                405                 410                 415     


Val Thr Asn Glu Asn Ala Ile Ile Pro Leu Pro Thr Ile Lys Trp Lys 
            420                 425                 430         


Pro Leu Ile His Ser Pro Ser Arg Thr Pro Val Leu Val Gly Ser Asp 
        435                 440                 445             


Glu Phe Asp Lys Cys Leu Ser Asn Asp Lys Phe Ser His Glu Glu Tyr 
    450                 455                 460                 


Ser Asn Gly Ala Leu Ser Ile Leu Gln Tyr Pro Tyr Asp Asn Gly Tyr 
465                 470                 475                 480 


Tyr Leu Pro Tyr Tyr Lys Arg Glu Arg Asn Lys Arg Ser Thr Gln Ile 
                485                 490                 495     


Thr Val Arg Phe Leu Asp Asn Pro His Tyr Asn Lys Asn Ile Arg Lys 
            500                 505                 510         


Lys Asp Pro Val Leu Leu Leu His Trp Trp Lys Glu Ile Val Ala Thr 
        515                 520                 525             


Ile Leu Phe Cys Ile Ile Ala Thr Thr Phe Ile Val Arg Arg Leu Phe 
    530                 535                 540                 


His Pro His Pro His Arg Gln Arg Lys Glu Ser Glu Thr Gln Cys Gln 
545                 550                 555                 560 


Thr Glu Asn Lys Tyr Asp Ser Val Ser Gly Glu Ala Asn Asp Ser Ser 
                565                 570                 575     


Trp Asn Asp Ile Lys Asn Ser Gly Tyr Ile Ser Arg Tyr Leu Thr Asp 
            580                 585                 590         


Phe Glu Pro Ile Gln Cys Leu Gly Arg Gly Gly Phe Gly Val Val Phe 
        595                 600                 605             


Glu Ala Lys Asn Lys Val Asp Asp Cys Asn Tyr Ala Ile Lys Arg Ile 
    610                 615                 620                 


Arg Leu Pro Asn Arg Glu Leu Ala Arg Glu Lys Val Met Arg Glu Val 
625                 630                 635                 640 


Lys Ala Leu Ala Lys Leu Glu His Pro Gly Ile Val Arg Tyr Phe Asn 
                645                 650                 655     


Ala Trp Leu Glu Ala Pro Pro Glu Lys Trp Gln Glu Lys Met Asp Glu 
            660                 665                 670         


Ile Trp Leu Lys Asp Glu Ser Thr Asp Trp Pro Leu Ser Ser Pro Ser 
        675                 680                 685             


Pro Met Asp Ala Pro Ser Val Lys Ile Arg Arg Met Asp Pro Phe Ala 
    690                 695                 700                 


Thr Lys Glu His Ile Glu Ile Ile Ala Pro Ser Pro Gln Arg Ser Arg 
705                 710                 715                 720 


Ser Phe Ser Val Gly Ile Ser Cys Asp Gln Thr Ser Ser Ser Glu Ser 
                725                 730                 735     


Gln Phe Ser Pro Leu Glu Phe Ser Gly Met Asp His Glu Asp Ile Ser 
            740                 745                 750         


Glu Ser Val Asp Ala Ala Tyr Asn Leu Gln Asp Ser Cys Leu Thr Asp 
        755                 760                 765             


Cys Asp Val Glu Asp Gly Thr Met Asp Gly Asn Asp Glu Gly His Ser 
    770                 775                 780                 


Phe Glu Leu Cys Pro Ser Glu Ala Ser Pro Tyr Val Arg Ser Arg Glu 
785                 790                 795                 800 


Arg Thr Ser Ser Ser Ile Val Phe Glu Asp Ser Gly Cys Asp Asn Ala 
                805                 810                 815     


Ser Ser Lys Glu Glu Pro Lys Thr Asn Arg Leu His Ile Gly Asn His 
            820                 825                 830         


Cys Ala Asn Lys Leu Thr Ala Phe Lys Pro Thr Ser Ser Lys Ser Ser 
        835                 840                 845             


Ser Glu Ala Thr Leu Ser Ile Ser Pro Pro Arg Pro Thr Thr Leu Ser 
    850                 855                 860                 


Leu Asp Leu Thr Lys Asn Thr Thr Glu Lys Leu Gln Pro Ser Ser Pro 
865                 870                 875                 880 


Lys Val Tyr Leu Tyr Ile Gln Met Gln Leu Cys Arg Lys Glu Asn Leu 
                885                 890                 895     


Lys Asp Trp Met Asn Gly Arg Cys Thr Ile Glu Glu Arg Glu Arg Ser 
            900                 905                 910         


Val Cys Leu His Ile Phe Leu Gln Ile Ala Glu Ala Val Glu Phe Leu 
        915                 920                 925             


His Ser Lys Gly Leu Met His Arg Asp Leu Lys Pro Ser Asn Ile Phe 
    930                 935                 940                 


Phe Thr Met Asp Asp Val Val Lys Val Gly Asp Phe Gly Leu Val Thr 
945                 950                 955                 960 


Ala Met Asp Gln Asp Glu Glu Glu Gln Thr Val Leu Thr Pro Met Pro 
                965                 970                 975     


Ala Tyr Ala Arg His Thr Gly Gln Val Gly Thr Lys Leu Tyr Met Ser 
            980                 985                 990         


Pro Glu Gln Ile His Gly Asn Ser  Tyr Ser His Lys Val  Asp Ile Phe 
        995                 1000                 1005             


Ser Leu  Gly Leu Ile Leu Phe  Glu Leu Leu Tyr Pro  Phe Ser Thr 
    1010                 1015                 1020             


Gln Met  Glu Arg Val Arg Thr  Leu Thr Asp Val Arg  Asn Leu Lys 
    1025                 1030                 1035             


Phe Pro  Pro Leu Phe Thr Gln  Lys Tyr Pro Cys Glu  Tyr Val Met 
    1040                 1045                 1050             


Val Gln  Asp Met Leu Ser Pro  Ser Pro Met Glu Arg  Pro Glu Ala 
    1055                 1060                 1065             


Ile Asn  Ile Ile Glu Asn Ala  Val Phe Glu Asp Leu  Asp Phe Pro 
    1070                 1075                 1080             


Gly Lys  Thr Val Leu Arg Gln  Arg Ser Arg Ser Leu  Ser Ser Ser 
    1085                 1090                 1095             


Gly Thr  Lys His Ser Arg Gln  Ser Asn Asn Ser His  Ser Pro Leu 
    1100                 1105                 1110             


Pro Ser  Asn 
    1115     


<210>  3454
<211>  1649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2AK4__Homo_sapiens__NP_001013725

<400>  3454

Met Ala Gly Gly Arg Gly Ala Pro Gly Arg Gly Arg Asp Glu Pro Pro 
1               5                   10                  15      


Glu Ser Tyr Pro Gln Arg Gln Asp His Glu Leu Gln Ala Leu Glu Ala 
            20                  25                  30          


Ile Tyr Gly Ala Asp Phe Gln Asp Leu Arg Pro Asp Ala Cys Gly Pro 
        35                  40                  45              


Val Lys Glu Pro Pro Glu Ile Asn Leu Val Leu Tyr Pro Gln Gly Leu 
    50                  55                  60                  


Thr Gly Glu Glu Val Tyr Val Lys Val Asp Leu Arg Val Lys Cys Pro 
65                  70                  75                  80  


Pro Thr Tyr Pro Asp Val Val Pro Glu Ile Glu Leu Lys Asn Ala Lys 
                85                  90                  95      


Gly Leu Ser Asn Glu Ser Val Asn Leu Leu Lys Ser Arg Leu Glu Glu 
            100                 105                 110         


Leu Ala Lys Lys His Cys Gly Glu Val Met Ile Phe Glu Leu Ala Tyr 
        115                 120                 125             


His Val Gln Ser Phe Leu Ser Glu His Asn Lys Pro Pro Pro Lys Ser 
    130                 135                 140                 


Phe His Glu Glu Met Leu Glu Arg Arg Ala Gln Glu Glu Gln Gln Arg 
145                 150                 155                 160 


Leu Leu Glu Ala Lys Arg Lys Glu Glu Gln Glu Gln Arg Glu Ile Leu 
                165                 170                 175     


His Glu Ile Gln Arg Arg Lys Glu Glu Ile Lys Glu Glu Lys Lys Arg 
            180                 185                 190         


Lys Glu Met Ala Lys Gln Glu Arg Leu Glu Ile Ala Ser Leu Ser Asn 
        195                 200                 205             


Gln Asp His Thr Ser Lys Lys Asp Pro Gly Gly His Arg Thr Ala Ala 
    210                 215                 220                 


Ile Leu His Gly Gly Ser Pro Asp Phe Val Gly Asn Gly Lys His Arg 
225                 230                 235                 240 


Ala Asn Ser Ser Gly Arg Ser Arg Arg Glu Arg Gln Tyr Ser Val Cys 
                245                 250                 255     


Asn Ser Glu Asp Ser Pro Gly Ser Cys Glu Ile Leu Tyr Phe Asn Met 
            260                 265                 270         


Gly Ser Pro Asp Gln Leu Met Val His Lys Gly Lys Cys Ile Gly Ser 
        275                 280                 285             


Asp Glu Gln Leu Gly Lys Leu Val Tyr Asn Ala Leu Glu Thr Ala Thr 
    290                 295                 300                 


Gly Gly Phe Val Leu Leu Tyr Glu Trp Val Leu Gln Trp Gln Lys Lys 
305                 310                 315                 320 


Met Gly Pro Phe Leu Thr Ser Gln Glu Lys Glu Lys Ile Asp Lys Cys 
                325                 330                 335     


Lys Lys Gln Ile Gln Gly Thr Glu Thr Glu Phe Asn Ser Leu Val Lys 
            340                 345                 350         


Leu Ser His Pro Asn Val Val Arg Tyr Leu Ala Met Asn Leu Lys Glu 
        355                 360                 365             


Gln Asp Asp Ser Ile Val Val Asp Ile Leu Val Glu His Ile Ser Gly 
    370                 375                 380                 


Val Ser Leu Ala Ala His Leu Ser His Ser Gly Pro Ile Pro Val His 
385                 390                 395                 400 


Gln Leu Arg Arg Tyr Thr Ala Gln Leu Leu Ser Gly Leu Asp Tyr Leu 
                405                 410                 415     


His Ser Asn Ser Val Val His Lys Val Leu Ser Ala Ser Asn Val Leu 
            420                 425                 430         


Val Asp Ala Glu Gly Thr Val Lys Ile Thr Asp Tyr Ser Ile Ser Lys 
        435                 440                 445             


Arg Leu Ala Asp Ile Cys Lys Glu Asp Val Phe Glu Gln Thr Arg Val 
    450                 455                 460                 


Arg Phe Ser Asp Asn Ala Leu Pro Tyr Lys Thr Gly Lys Lys Gly Asp 
465                 470                 475                 480 


Val Trp Arg Leu Gly Leu Leu Leu Leu Ser Leu Ser Gln Gly Gln Glu 
                485                 490                 495     


Cys Gly Glu Tyr Pro Val Thr Ile Pro Ser Asp Leu Pro Ala Asp Phe 
            500                 505                 510         


Gln Asp Phe Leu Lys Lys Cys Val Cys Leu Asp Asp Lys Glu Arg Trp 
        515                 520                 525             


Ser Pro Gln Gln Leu Leu Lys His Ser Phe Ile Asn Pro Gln Pro Lys 
    530                 535                 540                 


Met Pro Leu Val Glu Gln Ser Pro Glu Asp Ser Glu Gly Gln Asp Tyr 
545                 550                 555                 560 


Val Glu Thr Val Ile Pro Ser Asn Arg Leu Pro Ser Ala Ala Phe Phe 
                565                 570                 575     


Ser Glu Thr Gln Arg Gln Phe Ser Arg Tyr Phe Ile Glu Phe Glu Glu 
            580                 585                 590         


Leu Gln Leu Leu Gly Lys Gly Ala Phe Gly Ala Val Ile Lys Val Gln 
        595                 600                 605             


Asn Lys Leu Asp Gly Cys Cys Tyr Ala Val Lys Arg Ile Pro Ile Asn 
    610                 615                 620                 


Pro Ala Ser Arg Gln Phe Arg Arg Ile Lys Gly Glu Val Thr Leu Leu 
625                 630                 635                 640 


Ser Arg Leu His His Glu Asn Ile Val Arg Tyr Tyr Asn Ala Trp Ile 
                645                 650                 655     


Glu Arg His Glu Arg Pro Ala Gly Pro Gly Thr Pro Pro Pro Asp Ser 
            660                 665                 670         


Gly Pro Leu Ala Lys Asp Asp Arg Ala Ala Arg Gly Gln Pro Ala Ser 
        675                 680                 685             


Asp Thr Asp Gly Leu Asp Ser Val Glu Ala Ala Ala Pro Pro Pro Ile 
    690                 695                 700                 


Leu Ser Ser Ser Val Glu Trp Ser Thr Ser Gly Glu Arg Ser Ala Ser 
705                 710                 715                 720 


Ala Arg Phe Pro Ala Thr Gly Pro Gly Ser Ser Asp Asp Glu Asp Asp 
                725                 730                 735     


Asp Glu Asp Glu His Gly Gly Val Phe Ser Gln Ser Phe Leu Pro Ala 
            740                 745                 750         


Ser Asp Ser Glu Ser Asp Ile Ile Phe Asp Asn Glu Asp Glu Asn Ser 
        755                 760                 765             


Lys Ser Gln Asn Gln Asp Glu Asp Cys Asn Glu Lys Asn Gly Cys His 
    770                 775                 780                 


Glu Ser Glu Pro Ser Val Thr Thr Glu Ala Val His Tyr Leu Tyr Ile 
785                 790                 795                 800 


Gln Met Glu Tyr Cys Glu Lys Ser Thr Leu Arg Asp Thr Ile Asp Gln 
                805                 810                 815     


Gly Leu Tyr Arg Asp Thr Val Arg Leu Trp Arg Leu Phe Arg Glu Ile 
            820                 825                 830         


Leu Asp Gly Leu Ala Tyr Ile His Glu Lys Gly Met Ile His Arg Asp 
        835                 840                 845             


Leu Lys Pro Val Asn Ile Phe Leu Asp Ser Asp Asp His Val Lys Ile 
    850                 855                 860                 


Gly Asp Phe Gly Leu Ala Thr Asp His Leu Ala Phe Ser Ala Asp Ser 
865                 870                 875                 880 


Lys Gln Asp Asp Gln Thr Gly Asp Leu Ile Lys Ser Asp Pro Ser Gly 
                885                 890                 895     


His Leu Thr Gly Met Val Gly Thr Ala Leu Tyr Val Ser Pro Glu Val 
            900                 905                 910         


Gln Gly Ser Thr Lys Ser Ala Tyr Asn Gln Lys Val Asp Leu Phe Ser 
        915                 920                 925             


Leu Gly Ile Ile Phe Phe Glu Met Ser Tyr His Pro Met Val Thr Ala 
    930                 935                 940                 


Ser Glu Arg Ile Phe Val Leu Asn Gln Leu Arg Asp Pro Thr Ser Pro 
945                 950                 955                 960 


Lys Phe Pro Glu Asp Phe Asp Asp Gly Glu His Ala Lys Gln Lys Ser 
                965                 970                 975     


Val Ile Ser Trp Leu Leu Asn His Asp Pro Ala Lys Arg Pro Thr Ala 
            980                 985                 990         


Thr Glu Leu Leu Lys Ser Glu Leu  Leu Pro Pro Pro Gln  Met Glu Glu 
        995                 1000                 1005             


Ser Glu  Leu His Glu Val Leu  His His Thr Leu Thr  Asn Val Asp 
    1010                 1015                 1020             


Gly Lys  Ala Tyr Arg Thr Met  Met Ala Gln Ile Phe  Ser Gln Arg 
    1025                 1030                 1035             


Ile Ser  Pro Ala Ile Asp Tyr  Thr Tyr Asp Ser Asp  Ile Leu Lys 
    1040                 1045                 1050             


Gly Asn  Phe Ser Ile Arg Thr  Ala Lys Met Gln Gln  His Val Cys 
    1055                 1060                 1065             


Glu Thr  Ile Ile Arg Ile Phe  Lys Arg His Gly Ala  Val Gln Leu 
    1070                 1075                 1080             


Cys Thr  Pro Leu Leu Leu Pro  Arg Asn Arg Gln Ile  Tyr Glu His 
    1085                 1090                 1095             


Asn Glu  Ala Ala Leu Phe Met  Asp His Ser Gly Met  Leu Val Met 
    1100                 1105                 1110             


Leu Pro  Phe Asp Leu Arg Ile  Pro Phe Ala Arg Tyr  Val Ala Arg 
    1115                 1120                 1125             


Asn Asn  Ile Leu Asn Leu Lys  Arg Tyr Cys Ile Glu  Arg Val Phe 
    1130                 1135                 1140             


Arg Pro  Arg Lys Leu Asp Arg  Phe His Pro Lys Glu  Leu Leu Glu 
    1145                 1150                 1155             


Cys Ala  Phe Asp Ile Val Thr  Ser Thr Thr Asn Ser  Phe Leu Pro 
    1160                 1165                 1170             


Thr Ala  Glu Ile Ile Tyr Thr  Ile Tyr Glu Ile Ile  Gln Glu Phe 
    1175                 1180                 1185             


Pro Ala  Leu Gln Glu Arg Asn  Tyr Ser Ile Tyr Leu  Asn His Thr 
    1190                 1195                 1200             


Met Leu  Leu Lys Ala Ile Leu  Leu His Cys Gly Ile  Pro Glu Asp 
    1205                 1210                 1215             


Lys Leu  Ser Gln Val Tyr Ile  Ile Leu Tyr Asp Ala  Val Thr Glu 
    1220                 1225                 1230             


Lys Leu  Thr Arg Arg Glu Val  Glu Ala Lys Phe Cys  Asn Leu Ser 
    1235                 1240                 1245             


Leu Ser  Ser Asn Ser Leu Cys  Arg Leu Tyr Lys Phe  Ile Glu Gln 
    1250                 1255                 1260             


Lys Gly  Asp Leu Gln Asp Leu  Met Pro Thr Ile Asn  Ser Leu Ile 
    1265                 1270                 1275             


Lys Gln  Lys Thr Gly Ile Ala  Gln Leu Val Lys Tyr  Gly Leu Lys 
    1280                 1285                 1290             


Asp Leu  Glu Glu Val Val Gly  Leu Leu Lys Lys Leu  Gly Ile Lys 
    1295                 1300                 1305             


Leu Gln  Val Leu Ile Asn Leu  Gly Leu Val Tyr Lys  Val Gln Gln 
    1310                 1315                 1320             


His Asn  Gly Ile Ile Phe Gln  Phe Val Ala Phe Ile  Lys Arg Arg 
    1325                 1330                 1335             


Gln Arg  Ala Val Pro Glu Ile  Leu Ala Ala Gly Gly  Arg Tyr Asp 
    1340                 1345                 1350             


Leu Leu  Ile Pro Gln Phe Arg  Gly Pro Gln Ala Leu  Gly Pro Val 
    1355                 1360                 1365             


Pro Thr  Ala Ile Gly Val Ser  Ile Ala Ile Asp Lys  Ile Ser Ala 
    1370                 1375                 1380             


Ala Val  Leu Asn Met Glu Glu  Ser Val Thr Ile Ser  Ser Cys Asp 
    1385                 1390                 1395             


Leu Leu  Val Val Ser Val Gly  Gln Met Ser Met Ser  Arg Ala Ile 
    1400                 1405                 1410             


Asn Leu  Thr Gln Lys Leu Trp  Thr Ala Gly Ile Thr  Ala Glu Ile 
    1415                 1420                 1425             


Met Tyr  Asp Trp Ser Gln Ser  Gln Glu Glu Leu Gln  Glu Tyr Cys 
    1430                 1435                 1440             


Arg His  His Glu Ile Thr Tyr  Val Ala Leu Val Ser  Asp Lys Glu 
    1445                 1450                 1455             


Gly Ser  His Val Lys Val Lys  Ser Phe Glu Lys Glu  Arg Gln Thr 
    1460                 1465                 1470             


Glu Lys  Arg Val Leu Glu Thr  Glu Leu Val Asp His  Val Leu Gln 
    1475                 1480                 1485             


Lys Leu  Arg Thr Lys Val Thr  Asp Glu Arg Asn Gly  Arg Glu Ala 
    1490                 1495                 1500             


Ser Asp  Asn Leu Ala Val Gln  Asn Leu Lys Gly Ser  Phe Ser Asn 
    1505                 1510                 1515             


Ala Ser  Gly Leu Phe Glu Ile  His Gly Ala Thr Val  Val Pro Ile 
    1520                 1525                 1530             


Val Ser  Val Leu Ala Pro Glu  Lys Leu Ser Ala Ser  Thr Arg Arg 
    1535                 1540                 1545             


Arg Tyr  Glu Thr Gln Val Gln  Thr Arg Leu Gln Thr  Ser Leu Ala 
    1550                 1555                 1560             


Asn Leu  His Gln Lys Ser Ser  Glu Ile Glu Ile Leu  Ala Val Asp 
    1565                 1570                 1575             


Leu Pro  Lys Glu Thr Ile Leu  Gln Phe Leu Ser Leu  Glu Trp Asp 
    1580                 1585                 1590             


Ala Asp  Glu Gln Ala Phe Asn  Thr Thr Val Lys Gln  Leu Leu Ser 
    1595                 1600                 1605             


Arg Leu  Pro Lys Gln Arg Tyr  Leu Lys Leu Val Cys  Asp Glu Ile 
    1610                 1615                 1620             


Tyr Asn  Ile Lys Val Glu Lys  Lys Val Ser Val Leu  Phe Leu Tyr 
    1625                 1630                 1635             


Ser Tyr  Arg Asp Asp Tyr Tyr  Arg Ile Leu Phe 
    1640                 1645                 


<210>  3455
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2B1__Homo_sapiens__NP_001405

<400>  3455

Met Asp Asp Lys Glu Leu Ile Glu Tyr Phe Lys Ser Gln Met Lys Glu 
1               5                   10                  15      


Asp Pro Asp Met Ala Ser Ala Val Ala Ala Ile Arg Thr Leu Leu Glu 
            20                  25                  30          


Phe Leu Lys Arg Asp Lys Gly Glu Thr Ile Gln Gly Leu Arg Ala Asn 
        35                  40                  45              


Leu Thr Ser Ala Ile Glu Thr Leu Cys Gly Val Asp Ser Ser Val Ala 
    50                  55                  60                  


Val Ser Ser Gly Gly Glu Leu Phe Leu Arg Phe Ile Ser Leu Ala Ser 
65                  70                  75                  80  


Leu Glu Tyr Ser Asp Tyr Ser Lys Cys Lys Lys Ile Met Ile Glu Arg 
                85                  90                  95      


Gly Glu Leu Phe Leu Arg Arg Ile Ser Leu Ser Arg Asn Lys Ile Ala 
            100                 105                 110         


Asp Leu Cys His Thr Phe Ile Lys Asp Gly Ala Thr Ile Leu Thr His 
        115                 120                 125             


Ala Tyr Ser Arg Val Val Leu Arg Val Leu Glu Ala Ala Val Ala Ala 
    130                 135                 140                 


Lys Lys Arg Phe Ser Val Tyr Val Thr Glu Ser Gln Pro Asp Leu Ser 
145                 150                 155                 160 


Gly Lys Lys Met Ala Lys Ala Leu Cys His Leu Asn Val Pro Val Thr 
                165                 170                 175     


Val Val Leu Asp Ala Ala Val Gly Tyr Ile Met Glu Lys Ala Asp Leu 
            180                 185                 190         


Val Ile Val Gly Ala Glu Gly Val Val Glu Asn Gly Gly Ile Ile Asn 
        195                 200                 205             


Lys Ile Gly Thr Asn Gln Met Ala Val Cys Ala Lys Ala Gln Asn Lys 
    210                 215                 220                 


Pro Phe Tyr Val Val Ala Glu Ser Phe Lys Phe Val Arg Leu Phe Pro 
225                 230                 235                 240 


Leu Asn Gln Gln Asp Val Pro Asp Lys Phe Lys Tyr Lys Ala Asp Thr 
                245                 250                 255     


Leu Lys Val Ala Gln Thr Gly Gln Asp Leu Lys Glu Glu His Pro Trp 
            260                 265                 270         


Val Asp Tyr Thr Ala Pro Ser Leu Ile Thr Leu Leu Phe Thr Asp Leu 
        275                 280                 285             


Gly Val Leu Thr Pro Ser Ala Val Ser Asp Glu Leu Ile Lys Leu Tyr 
    290                 295                 300                 


Leu 
305 


<210>  3456
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2B2__Homo_sapiens__NP_055054

<400>  3456

Met Pro Gly Ser Ala Ala Lys Gly Ser Glu Leu Ser Glu Arg Ile Glu 
1               5                   10                  15      


Ser Phe Val Glu Thr Leu Lys Arg Gly Gly Gly Pro Arg Ser Ser Glu 
            20                  25                  30          


Glu Met Ala Arg Glu Thr Leu Gly Leu Leu Arg Gln Ile Ile Thr Asp 
        35                  40                  45              


His Arg Trp Ser Asn Ala Gly Glu Leu Met Glu Leu Ile Arg Arg Glu 
    50                  55                  60                  


Gly Arg Arg Met Thr Ala Ala Gln Pro Ser Glu Thr Thr Val Gly Asn 
65                  70                  75                  80  


Met Val Arg Arg Val Leu Lys Ile Ile Arg Glu Glu Tyr Gly Arg Leu 
                85                  90                  95      


His Gly Arg Ser Asp Glu Ser Asp Gln Gln Glu Ser Leu His Lys Leu 
            100                 105                 110         


Leu Thr Ser Gly Gly Leu Asn Glu Asp Phe Ser Phe His Tyr Ala Gln 
        115                 120                 125             


Leu Gln Ser Asn Ile Ile Glu Ala Ile Asn Glu Leu Leu Val Glu Leu 
    130                 135                 140                 


Glu Gly Thr Met Glu Asn Ile Ala Ala Gln Ala Leu Glu His Ile His 
145                 150                 155                 160 


Ser Asn Glu Val Ile Met Thr Ile Gly Phe Ser Arg Thr Val Glu Ala 
                165                 170                 175     


Phe Leu Lys Glu Ala Ala Arg Lys Arg Lys Phe His Val Ile Val Ala 
            180                 185                 190         


Glu Cys Ala Pro Phe Cys Gln Gly His Glu Met Ala Val Asn Leu Ser 
        195                 200                 205             


Lys Ala Gly Ile Glu Thr Thr Val Met Thr Asp Ala Ala Ile Phe Ala 
    210                 215                 220                 


Val Met Ser Arg Val Asn Lys Val Ile Ile Gly Thr Lys Thr Ile Leu 
225                 230                 235                 240 


Ala Asn Gly Ala Leu Arg Ala Val Thr Gly Thr His Thr Leu Ala Leu 
                245                 250                 255     


Ala Ala Lys His His Ser Thr Pro Leu Ile Val Cys Ala Pro Met Phe 
            260                 265                 270         


Lys Leu Ser Pro Gln Phe Pro Asn Glu Glu Asp Ser Phe His Lys Phe 
        275                 280                 285             


Val Ala Pro Glu Glu Val Leu Pro Phe Thr Glu Gly Asp Ile Leu Glu 
    290                 295                 300                 


Lys Val Ser Val His Cys Pro Val Phe Asp Tyr Val Pro Pro Glu Leu 
305                 310                 315                 320 


Ile Thr Leu Phe Ile Ser Asn Ile Gly Gly Asn Ala Pro Ser Tyr Ile 
                325                 330                 335     


Tyr Arg Leu Met Ser Glu Leu Tyr His Pro Asp Asp His Val Leu 
            340                 345                 350     


<210>  3457
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2B3__Homo_sapiens__XP_011540698

<400>  3457

Met Glu Phe Gln Ala Val Val Met Ala Val Gly Gly Gly Ser Arg Met 
1               5                   10                  15      


Thr Asp Leu Thr Ser Ser Ile Pro Lys Pro Leu Leu Pro Val Gly Asn 
            20                  25                  30          


Lys Pro Leu Ile Trp Tyr Pro Leu Asn Leu Leu Glu Arg Val Gly Phe 
        35                  40                  45              


Glu Glu Val Ile Val Val Thr Thr Arg Asp Val Gln Lys Ala Leu Cys 
    50                  55                  60                  


Ala Glu Phe Lys Met Lys Met Lys Pro Asp Ile Val Cys Ile Pro Asp 
65                  70                  75                  80  


Asp Ala Asp Met Gly Thr Ala Asp Ser Leu Arg Tyr Ile Tyr Pro Lys 
                85                  90                  95      


Leu Lys Thr Asp Val Leu Val Leu Ser Cys Asp Leu Ile Thr Asp Val 
            100                 105                 110         


Ala Leu His Glu Val Val Asp Leu Phe Arg Ala Tyr Asp Ala Ser Leu 
        115                 120                 125             


Ala Met Leu Met Arg Lys Gly Gln Asp Ser Ile Glu Pro Val Pro Gly 
    130                 135                 140                 


Gln Lys Gly Lys Lys Lys Ala Val Glu Gln Arg Asp Phe Ile Gly Val 
145                 150                 155                 160 


Asp Ser Thr Gly Lys Arg Leu Leu Phe Met Ala Asn Glu Ala Asp Leu 
                165                 170                 175     


Asp Glu Glu Leu Val Ile Lys Gly Ser Ile Leu Gln Lys Ser Ile Thr 
            180                 185                 190         


Ser Ile Arg Ser Glu Leu Ile Pro Tyr Leu Val Arg Lys Gln Phe Ser 
        195                 200                 205             


Ser Ala Ser Ser Gln Gln Gly Gln Glu Glu Lys Glu Glu Asp Leu Lys 
    210                 215                 220                 


Lys Lys Glu Leu Lys Ser Leu Asp Ile Tyr Ser Phe Ile Lys Glu Ala 
225                 230                 235                 240 


Asn Thr Leu Asn Leu Ala Pro Tyr Asp Ala Cys Trp Asn Ala Cys Arg 
                245                 250                 255     


Gly Asp Arg Trp Glu Asp Leu Ser Arg Ser Gln Val Arg Cys Tyr Val 
            260                 265                 270         


His Ile Met Lys Glu Gly Leu Cys Ser Arg Val Ser Thr Leu Gly Leu 
        275                 280                 285             


Tyr Met Glu Ala Asn Arg Gln Val Pro Lys Leu Leu Ser Ala Leu Cys 
    290                 295                 300                 


Pro Glu Glu Pro Pro Val His Ser Ser Ala Gln Ile Val Ser Lys His 
305                 310                 315                 320 


Leu Val Gly Val Asp Ser Leu Ile Gly Pro Glu Thr Gln Ile Gly Glu 
                325                 330                 335     


Lys Ser Ser Ile Lys Arg Ser Val Ile Gly Ser Ser Cys Leu Ile Lys 
            340                 345                 350         


Asp Arg Val Thr Ile Thr Asn Cys Leu Leu Met Asn Ser Val Thr Val 
        355                 360                 365             


Glu Glu Gly Ser Asn Ile Gln Gly Ser Val Ile Cys Asn Asn Ala Val 
    370                 375                 380                 


Ile Glu Lys Gly Ala Asp Ile Lys Asp Cys Leu Ile Gly Ser Gly Gln 
385                 390                 395                 400 


Arg Ile Glu Ala Lys Ala Lys Arg Val Asn Glu Val Ile Val Gly Asn 
                405                 410                 415     


Asp Gln Leu Met Glu Ile 
            420         


<210>  3458
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2B4__Homo_sapiens__NP_001029288

<400>  3458

Met Ala Ala Val Ala Val Ala Val Arg Glu Asp Ser Gly Ser Gly Met 
1               5                   10                  15      


Lys Ala Glu Leu Pro Pro Gly Pro Gly Ala Val Gly Arg Glu Met Thr 
            20                  25                  30          


Lys Glu Glu Lys Leu Gln Leu Arg Lys Glu Lys Lys Gln Gln Lys Lys 
        35                  40                  45              


Lys Arg Lys Glu Glu Lys Gly Ala Glu Pro Glu Thr Gly Ser Ala Val 
    50                  55                  60                  


Ser Ala Ala Gln Cys Gln Val Gly Pro Thr Arg Glu Leu Pro Glu Ser 
65                  70                  75                  80  


Gly Ile Gln Leu Gly Thr Pro Arg Glu Lys Val Pro Ala Gly Arg Ser 
                85                  90                  95      


Lys Ala Glu Leu Arg Ala Glu Arg Arg Ala Lys Gln Glu Ala Glu Arg 
            100                 105                 110         


Ala Leu Lys Gln Ala Arg Lys Gly Glu Gln Gly Gly Pro Pro Pro Lys 
        115                 120                 125             


Ala Ser Pro Ser Thr Ala Gly Glu Thr Pro Ser Gly Val Lys Arg Leu 
    130                 135                 140                 


Pro Glu Tyr Pro Gln Val Asp Asp Leu Leu Leu Arg Arg Leu Val Lys 
145                 150                 155                 160 


Lys Pro Glu Arg Gln Gln Val Pro Thr Arg Lys Asp Tyr Gly Ser Lys 
                165                 170                 175     


Val Ser Leu Phe Ser His Leu Pro Gln Tyr Ser Arg Gln Asn Ser Leu 
            180                 185                 190         


Thr Gln Phe Met Ser Ile Pro Ser Ser Val Ile His Pro Ala Met Val 
        195                 200                 205             


Arg Leu Gly Leu Gln Tyr Ser Gln Gly Leu Val Ser Gly Ser Asn Ala 
    210                 215                 220                 


Arg Cys Ile Ala Leu Leu Arg Ala Leu Gln Gln Val Ile Gln Asp Tyr 
225                 230                 235                 240 


Thr Thr Pro Pro Asn Glu Glu Leu Ser Arg Asp Leu Val Asn Lys Leu 
                245                 250                 255     


Lys Pro Tyr Met Ser Phe Leu Thr Gln Cys Arg Pro Leu Ser Ala Ser 
            260                 265                 270         


Met His Asn Ala Ile Lys Phe Leu Asn Lys Glu Ile Thr Ser Val Gly 
        275                 280                 285             


Ser Ser Lys Arg Glu Glu Glu Ala Lys Ser Glu Leu Arg Ala Ala Ile 
    290                 295                 300                 


Asp Arg Tyr Val Gln Glu Lys Ile Val Leu Ala Ala Gln Ala Ile Ser 
305                 310                 315                 320 


Arg Phe Ala Tyr Gln Lys Ile Ser Asn Gly Asp Val Ile Leu Val Tyr 
                325                 330                 335     


Gly Cys Ser Ser Leu Val Ser Arg Ile Leu Gln Glu Ala Trp Thr Glu 
            340                 345                 350         


Gly Arg Arg Phe Arg Val Val Val Val Asp Ser Arg Pro Trp Leu Glu 
        355                 360                 365             


Gly Arg His Thr Leu Arg Ser Leu Val His Ala Gly Val Pro Ala Ser 
    370                 375                 380                 


Tyr Leu Leu Ile Pro Ala Ala Ser Tyr Val Leu Pro Glu Val Ser Lys 
385                 390                 395                 400 


Val Leu Leu Gly Ala His Ala Leu Leu Ala Asn Gly Ser Val Met Ser 
                405                 410                 415     


Arg Val Gly Thr Ala Gln Leu Ala Leu Val Ala Arg Ala His Asn Val 
            420                 425                 430         


Pro Val Leu Val Cys Cys Glu Thr Tyr Lys Phe Cys Glu Arg Val Gln 
        435                 440                 445             


Thr Asp Ala Phe Val Ser Asn Glu Leu Asp Asp Pro Asp Asp Leu Gln 
    450                 455                 460                 


Cys Lys Arg Gly Glu His Val Ala Leu Ala Asn Trp Gln Asn His Ala 
465                 470                 475                 480 


Ser Leu Arg Leu Leu Asn Leu Val Tyr Asp Val Thr Pro Pro Glu Leu 
                485                 490                 495     


Val Asp Leu Val Ile Thr Glu Leu Gly Met Ile Pro Cys Ser Ser Val 
            500                 505                 510         


Pro Val Val Leu Arg Val Lys Ser Ser Asp Gln 
        515                 520             


<210>  3459
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2B5__Homo_sapiens__NP_003898

<400>  3459

Met Ala Ala Pro Val Val Ala Pro Pro Gly Val Val Val Ser Arg Ala 
1               5                   10                  15      


Asn Lys Arg Ser Gly Ala Gly Pro Gly Gly Ser Gly Gly Gly Gly Ala 
            20                  25                  30          


Arg Gly Ala Glu Glu Glu Pro Pro Pro Pro Leu Gln Ala Val Leu Val 
        35                  40                  45              


Ala Asp Ser Phe Asp Arg Arg Phe Phe Pro Ile Ser Lys Asp Gln Pro 
    50                  55                  60                  


Arg Val Leu Leu Pro Leu Ala Asn Val Ala Leu Ile Asp Tyr Thr Leu 
65                  70                  75                  80  


Glu Phe Leu Thr Ala Thr Gly Val Gln Glu Thr Phe Val Phe Cys Cys 
                85                  90                  95      


Trp Lys Ala Ala Gln Ile Lys Glu His Leu Leu Lys Ser Lys Trp Cys 
            100                 105                 110         


Arg Pro Thr Ser Leu Asn Val Val Arg Ile Ile Thr Ser Glu Leu Tyr 
        115                 120                 125             


Arg Ser Leu Gly Asp Val Leu Arg Asp Val Asp Ala Lys Ala Leu Val 
    130                 135                 140                 


Arg Ser Asp Phe Leu Leu Val Tyr Gly Asp Val Ile Ser Asn Ile Asn 
145                 150                 155                 160 


Ile Thr Arg Ala Leu Glu Glu His Arg Leu Arg Arg Lys Leu Glu Lys 
                165                 170                 175     


Asn Val Ser Val Met Thr Met Ile Phe Lys Glu Ser Ser Pro Ser His 
            180                 185                 190         


Pro Thr Arg Cys His Glu Asp Asn Val Val Val Ala Val Asp Ser Thr 
        195                 200                 205             


Thr Asn Arg Val Leu His Phe Gln Lys Thr Gln Gly Leu Arg Arg Phe 
    210                 215                 220                 


Ala Phe Pro Leu Ser Leu Phe Gln Gly Ser Ser Asp Gly Val Glu Val 
225                 230                 235                 240 


Arg Tyr Asp Leu Leu Asp Cys His Ile Ser Ile Cys Ser Pro Gln Val 
                245                 250                 255     


Ala Gln Leu Phe Thr Asp Asn Phe Asp Tyr Gln Thr Arg Asp Asp Phe 
            260                 265                 270         


Val Arg Gly Leu Leu Val Asn Glu Glu Ile Leu Gly Asn Gln Ile His 
        275                 280                 285             


Met His Val Thr Ala Lys Glu Tyr Gly Ala Arg Val Ser Asn Leu His 
    290                 295                 300                 


Met Tyr Ser Ala Val Cys Ala Asp Val Ile Arg Arg Trp Val Tyr Pro 
305                 310                 315                 320 


Leu Thr Pro Glu Ala Asn Phe Thr Asp Ser Thr Thr Gln Ser Cys Thr 
                325                 330                 335     


His Ser Arg His Asn Ile Tyr Arg Gly Pro Glu Val Ser Leu Gly His 
            340                 345                 350         


Gly Ser Ile Leu Glu Glu Asn Val Leu Leu Gly Ser Gly Thr Val Ile 
        355                 360                 365             


Gly Ser Asn Cys Phe Ile Thr Asn Ser Val Ile Gly Pro Gly Cys His 
    370                 375                 380                 


Ile Gly Asp Asn Val Val Leu Asp Gln Thr Tyr Leu Trp Gln Gly Val 
385                 390                 395                 400 


Arg Val Ala Ala Gly Ala Gln Ile His Gln Ser Leu Leu Cys Asp Asn 
                405                 410                 415     


Ala Glu Val Lys Glu Arg Val Thr Leu Lys Pro Arg Ser Val Leu Thr 
            420                 425                 430         


Ser Gln Val Val Val Gly Pro Asn Ile Thr Leu Pro Glu Gly Ser Val 
        435                 440                 445             


Ile Ser Leu His Pro Pro Asp Ala Glu Glu Asp Glu Asp Asp Gly Glu 
    450                 455                 460                 


Phe Ser Asp Asp Ser Gly Ala Asp Gln Glu Lys Asp Lys Val Lys Met 
465                 470                 475                 480 


Lys Gly Tyr Asn Pro Ala Glu Val Gly Ala Ala Gly Lys Gly Tyr Leu 
                485                 490                 495     


Trp Lys Ala Ala Gly Met Asn Met Glu Glu Glu Glu Glu Leu Gln Gln 
            500                 505                 510         


Asn Leu Trp Gly Leu Lys Ile Asn Met Glu Glu Glu Ser Glu Ser Glu 
        515                 520                 525             


Ser Glu Gln Ser Met Asp Ser Glu Glu Pro Asp Ser Arg Gly Gly Ser 
    530                 535                 540                 


Pro Gln Met Asp Asp Ile Lys Val Phe Gln Asn Glu Val Leu Gly Thr 
545                 550                 555                 560 


Leu Gln Arg Gly Lys Glu Glu Asn Ile Ser Cys Asp Asn Leu Val Leu 
                565                 570                 575     


Glu Ile Asn Ser Leu Lys Tyr Ala Tyr Asn Ile Ser Leu Lys Glu Val 
            580                 585                 590         


Met Gln Val Leu Ser His Val Val Leu Glu Phe Pro Leu Gln Gln Met 
        595                 600                 605             


Asp Ser Pro Leu Asp Ser Ser Arg Tyr Cys Ala Leu Leu Leu Pro Leu 
    610                 615                 620                 


Leu Lys Ala Trp Ser Pro Val Phe Arg Asn Tyr Ile Lys Arg Ala Ala 
625                 630                 635                 640 


Asp His Leu Glu Ala Leu Ala Ala Ile Glu Asp Phe Phe Leu Glu His 
                645                 650                 655     


Glu Ala Leu Gly Ile Ser Met Ala Lys Val Leu Met Ala Phe Tyr Gln 
            660                 665                 670         


Leu Glu Ile Leu Ala Glu Glu Thr Ile Leu Ser Trp Phe Ser Gln Arg 
        675                 680                 685             


Asp Thr Thr Asp Lys Gly Gln Gln Leu Arg Lys Asn Gln Gln Leu Gln 
    690                 695                 700                 


Arg Phe Ile Gln Trp Leu Lys Glu Ala Glu Glu Glu Ser Ser Glu Asp 
705                 710                 715                 720 


Asp 
    


<210>  3460
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2S1__Homo_sapiens__NP_004085

<400>  3460

Met Pro Gly Leu Ser Cys Arg Phe Tyr Gln His Lys Phe Pro Glu Val 
1               5                   10                  15      


Glu Asp Val Val Met Val Asn Val Arg Ser Ile Ala Glu Met Gly Ala 
            20                  25                  30          


Tyr Val Ser Leu Leu Glu Tyr Asn Asn Ile Glu Gly Met Ile Leu Leu 
        35                  40                  45              


Ser Glu Leu Ser Arg Arg Arg Ile Arg Ser Ile Asn Lys Leu Ile Arg 
    50                  55                  60                  


Ile Gly Arg Asn Glu Cys Val Val Val Ile Arg Val Asp Lys Glu Lys 
65                  70                  75                  80  


Gly Tyr Ile Asp Leu Ser Lys Arg Arg Val Ser Pro Glu Glu Ala Ile 
                85                  90                  95      


Lys Cys Glu Asp Lys Phe Thr Lys Ser Lys Thr Val Tyr Ser Ile Leu 
            100                 105                 110         


Arg His Val Ala Glu Val Leu Glu Tyr Thr Lys Asp Glu Gln Leu Glu 
        115                 120                 125             


Ser Leu Phe Gln Arg Thr Ala Trp Val Phe Asp Asp Lys Tyr Lys Arg 
    130                 135                 140                 


Pro Gly Tyr Gly Ala Tyr Asp Ala Phe Lys His Ala Val Ser Asp Pro 
145                 150                 155                 160 


Ser Ile Leu Asp Ser Leu Asp Leu Asn Glu Asp Glu Arg Glu Val Leu 
                165                 170                 175     


Ile Asn Asn Ile Asn Arg Arg Leu Thr Pro Gln Ala Val Lys Ile Arg 
            180                 185                 190         


Ala Asp Ile Glu Val Ala Cys Tyr Gly Tyr Glu Gly Ile Asp Ala Val 
        195                 200                 205             


Lys Glu Ala Leu Arg Ala Gly Leu Asn Cys Ser Thr Glu Asn Met Pro 
    210                 215                 220                 


Ile Lys Ile Asn Leu Ile Ala Pro Pro Arg Tyr Val Met Thr Thr Thr 
225                 230                 235                 240 


Thr Leu Glu Arg Thr Glu Gly Leu Ser Val Leu Ser Gln Ala Met Ala 
                245                 250                 255     


Val Ile Lys Glu Lys Ile Glu Glu Lys Arg Gly Val Phe Asn Val Gln 
            260                 265                 270         


Met Glu Pro Lys Val Val Thr Asp Thr Asp Glu Thr Glu Leu Ala Arg 
        275                 280                 285             


Gln Met Glu Arg Leu Glu Arg Glu Asn Ala Glu Val Asp Gly Asp Asp 
    290                 295                 300                 


Asp Ala Glu Glu Met Glu Ala Lys Ala Glu Asp 
305                 310                 315 


<210>  3461
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2S2__Homo_sapiens__NP_003899

<400>  3461

Met Ser Gly Asp Glu Met Ile Phe Asp Pro Thr Met Ser Lys Lys Lys 
1               5                   10                  15      


Lys Lys Lys Lys Lys Pro Phe Met Leu Asp Glu Glu Gly Asp Thr Gln 
            20                  25                  30          


Thr Glu Glu Thr Gln Pro Ser Glu Thr Lys Glu Val Glu Pro Glu Pro 
        35                  40                  45              


Thr Glu Asp Lys Asp Leu Glu Ala Asp Glu Glu Asp Thr Arg Lys Lys 
    50                  55                  60                  


Asp Ala Ser Asp Asp Leu Asp Asp Leu Asn Phe Phe Asn Gln Lys Lys 
65                  70                  75                  80  


Lys Lys Lys Lys Thr Lys Lys Ile Phe Asp Ile Asp Glu Ala Glu Glu 
                85                  90                  95      


Gly Val Lys Asp Leu Lys Ile Glu Ser Asp Val Gln Glu Pro Thr Glu 
            100                 105                 110         


Pro Glu Asp Asp Leu Asp Ile Met Leu Gly Asn Lys Lys Lys Lys Lys 
        115                 120                 125             


Lys Asn Val Lys Phe Pro Asp Glu Asp Glu Ile Leu Glu Lys Asp Glu 
    130                 135                 140                 


Ala Leu Glu Asp Glu Asp Asn Lys Lys Asp Asp Gly Ile Ser Phe Ser 
145                 150                 155                 160 


Asn Gln Thr Gly Pro Ala Trp Ala Gly Ser Glu Arg Asp Tyr Thr Tyr 
                165                 170                 175     


Glu Glu Leu Leu Asn Arg Val Phe Asn Ile Met Arg Glu Lys Asn Pro 
            180                 185                 190         


Asp Met Val Ala Gly Glu Lys Arg Lys Phe Val Met Lys Pro Pro Gln 
        195                 200                 205             


Val Val Arg Val Gly Thr Lys Lys Thr Ser Phe Val Asn Phe Thr Asp 
    210                 215                 220                 


Ile Cys Lys Leu Leu His Arg Gln Pro Lys His Leu Leu Ala Phe Leu 
225                 230                 235                 240 


Leu Ala Glu Leu Gly Thr Ser Gly Ser Ile Asp Gly Asn Asn Gln Leu 
                245                 250                 255     


Val Ile Lys Gly Arg Phe Gln Gln Lys Gln Ile Glu Asn Val Leu Arg 
            260                 265                 270         


Arg Tyr Ile Lys Glu Tyr Val Thr Cys His Thr Cys Arg Ser Pro Asp 
        275                 280                 285             


Thr Ile Leu Gln Lys Asp Thr Arg Leu Tyr Phe Leu Gln Cys Glu Thr 
    290                 295                 300                 


Cys His Ser Arg Cys Ser Val Ala Ser Ile Lys Thr Gly Phe Gln Ala 
305                 310                 315                 320 


Val Thr Gly Lys Arg Ala Gln Leu Arg Ala Lys Ala Asn 
                325                 330             


<210>  3462
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF2S3__Homo_sapiens__NP_001406

<400>  3462

Met Ala Gly Gly Glu Ala Gly Val Thr Leu Gly Gln Pro His Leu Ser 
1               5                   10                  15      


Arg Gln Asp Leu Thr Thr Leu Asp Val Thr Lys Leu Thr Pro Leu Ser 
            20                  25                  30          


His Glu Val Ile Ser Arg Gln Ala Thr Ile Asn Ile Gly Thr Ile Gly 
        35                  40                  45              


His Val Ala His Gly Lys Ser Thr Val Val Lys Ala Ile Ser Gly Val 
    50                  55                  60                  


His Thr Val Arg Phe Lys Asn Glu Leu Glu Arg Asn Ile Thr Ile Lys 
65                  70                  75                  80  


Leu Gly Tyr Ala Asn Ala Lys Ile Tyr Lys Leu Asp Asp Pro Ser Cys 
                85                  90                  95      


Pro Arg Pro Glu Cys Tyr Arg Ser Cys Gly Ser Ser Thr Pro Asp Glu 
            100                 105                 110         


Phe Pro Thr Asp Ile Pro Gly Thr Lys Gly Asn Phe Lys Leu Val Arg 
        115                 120                 125             


His Val Ser Phe Val Asp Cys Pro Gly His Asp Ile Leu Met Ala Thr 
    130                 135                 140                 


Met Leu Asn Gly Ala Ala Val Met Asp Ala Ala Leu Leu Leu Ile Ala 
145                 150                 155                 160 


Gly Asn Glu Ser Cys Pro Gln Pro Gln Thr Ser Glu His Leu Ala Ala 
                165                 170                 175     


Ile Glu Ile Met Lys Leu Lys His Ile Leu Ile Leu Gln Asn Lys Ile 
            180                 185                 190         


Asp Leu Val Lys Glu Ser Gln Ala Lys Glu Gln Tyr Glu Gln Ile Leu 
        195                 200                 205             


Ala Phe Val Gln Gly Thr Val Ala Glu Gly Ala Pro Ile Ile Pro Ile 
    210                 215                 220                 


Ser Ala Gln Leu Lys Tyr Asn Ile Glu Val Val Cys Glu Tyr Ile Val 
225                 230                 235                 240 


Lys Lys Ile Pro Val Pro Pro Arg Asp Phe Thr Ser Glu Pro Arg Leu 
                245                 250                 255     


Ile Val Ile Arg Ser Phe Asp Val Asn Lys Pro Gly Cys Glu Val Asp 
            260                 265                 270         


Asp Leu Lys Gly Gly Val Ala Gly Gly Ser Ile Leu Lys Gly Val Leu 
        275                 280                 285             


Lys Val Gly Gln Glu Ile Glu Val Arg Pro Gly Ile Val Ser Lys Asp 
    290                 295                 300                 


Ser Glu Gly Lys Leu Met Cys Lys Pro Ile Phe Ser Lys Ile Val Ser 
305                 310                 315                 320 


Leu Phe Ala Glu His Asn Asp Leu Gln Tyr Ala Ala Pro Gly Gly Leu 
                325                 330                 335     


Ile Gly Val Gly Thr Lys Ile Asp Pro Thr Leu Cys Arg Ala Asp Arg 
            340                 345                 350         


Met Val Gly Gln Val Leu Gly Ala Val Gly Ala Leu Pro Glu Ile Phe 
        355                 360                 365             


Thr Glu Leu Glu Ile Ser Tyr Phe Leu Leu Arg Arg Leu Leu Gly Val 
    370                 375                 380                 


Arg Thr Glu Gly Asp Lys Lys Ala Ala Lys Val Gln Lys Leu Ser Lys 
385                 390                 395                 400 


Asn Glu Val Leu Met Val Asn Ile Gly Ser Leu Ser Thr Gly Gly Arg 
                405                 410                 415     


Val Ser Ala Val Lys Ala Asp Leu Gly Lys Ile Val Leu Thr Asn Pro 
            420                 425                 430         


Val Cys Thr Glu Val Gly Glu Lys Ile Ala Leu Ser Arg Arg Val Glu 
        435                 440                 445             


Lys His Trp Arg Leu Ile Gly Trp Gly Gln Ile Arg Arg Gly Val Thr 
    450                 455                 460                 


Ile Lys Pro Thr Val Asp Asp Asp 
465                 470         


<210>  3463
<211>  1382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3A__Homo_sapiens__NP_003741

<400>  3463

Met Pro Ala Tyr Phe Gln Arg Pro Glu Asn Ala Leu Lys Arg Ala Asn 
1               5                   10                  15      


Glu Phe Leu Glu Val Gly Lys Lys Gln Pro Ala Leu Asp Val Leu Tyr 
            20                  25                  30          


Asp Val Met Lys Ser Lys Lys His Arg Thr Trp Gln Lys Ile His Glu 
        35                  40                  45              


Pro Ile Met Leu Lys Tyr Leu Glu Leu Cys Val Asp Leu Arg Lys Ser 
    50                  55                  60                  


His Leu Ala Lys Glu Gly Leu Tyr Gln Tyr Lys Asn Ile Cys Gln Gln 
65                  70                  75                  80  


Val Asn Ile Lys Ser Leu Glu Asp Val Val Arg Ala Tyr Leu Lys Met 
                85                  90                  95      


Ala Glu Glu Lys Thr Glu Ala Ala Lys Glu Glu Ser Gln Gln Met Val 
            100                 105                 110         


Leu Asp Ile Glu Asp Leu Asp Asn Ile Gln Thr Pro Glu Ser Val Leu 
        115                 120                 125             


Leu Ser Ala Val Ser Gly Glu Asp Thr Gln Asp Arg Thr Asp Arg Leu 
    130                 135                 140                 


Leu Leu Thr Pro Trp Val Lys Phe Leu Trp Glu Ser Tyr Arg Gln Cys 
145                 150                 155                 160 


Leu Asp Leu Leu Arg Asn Asn Ser Arg Val Glu Arg Leu Tyr His Asp 
                165                 170                 175     


Ile Ala Gln Gln Ala Phe Lys Phe Cys Leu Gln Tyr Thr Arg Lys Ala 
            180                 185                 190         


Glu Phe Arg Lys Leu Cys Asp Asn Leu Arg Met His Leu Ser Gln Ile 
        195                 200                 205             


Gln Arg His His Asn Gln Ser Thr Ala Ile Asn Leu Asn Asn Pro Glu 
    210                 215                 220                 


Ser Gln Ser Met His Leu Glu Thr Arg Leu Val Gln Leu Asp Ser Ala 
225                 230                 235                 240 


Ile Ser Met Glu Leu Trp Gln Glu Ala Phe Lys Ala Val Glu Asp Ile 
                245                 250                 255     


His Gly Leu Phe Ser Leu Ser Lys Lys Pro Pro Lys Pro Gln Leu Met 
            260                 265                 270         


Ala Asn Tyr Tyr Asn Lys Val Ser Thr Val Phe Trp Lys Ser Gly Asn 
        275                 280                 285             


Ala Leu Phe His Ala Ser Thr Leu His Arg Leu Tyr His Leu Ser Arg 
    290                 295                 300                 


Glu Met Arg Lys Asn Leu Thr Gln Asp Glu Met Gln Arg Met Ser Thr 
305                 310                 315                 320 


Arg Val Leu Leu Ala Thr Leu Ser Ile Pro Ile Thr Pro Glu Arg Thr 
                325                 330                 335     


Asp Ile Ala Arg Leu Leu Asp Met Asp Gly Ile Ile Val Glu Lys Gln 
            340                 345                 350         


Arg Arg Leu Ala Thr Leu Leu Gly Leu Gln Ala Pro Pro Thr Arg Ile 
        355                 360                 365             


Gly Leu Ile Asn Asp Met Val Arg Phe Asn Val Leu Gln Tyr Val Val 
    370                 375                 380                 


Pro Glu Val Lys Asp Leu Tyr Asn Trp Leu Glu Val Glu Phe Asn Pro 
385                 390                 395                 400 


Leu Lys Leu Cys Glu Arg Val Thr Lys Val Leu Asn Trp Val Arg Glu 
                405                 410                 415     


Gln Pro Glu Lys Glu Pro Glu Leu Gln Gln Tyr Val Pro Gln Leu Gln 
            420                 425                 430         


Asn Asn Thr Ile Leu Arg Leu Leu Gln Gln Val Ser Gln Ile Tyr Gln 
        435                 440                 445             


Ser Ile Glu Phe Ser Arg Leu Thr Ser Leu Val Pro Phe Val Asp Ala 
    450                 455                 460                 


Phe Gln Leu Glu Arg Ala Ile Val Asp Ala Ala Arg His Cys Asp Leu 
465                 470                 475                 480 


Gln Val Arg Ile Asp His Thr Ser Arg Thr Leu Ser Phe Gly Ser Asp 
                485                 490                 495     


Leu Asn Tyr Ala Thr Arg Glu Asp Ala Pro Ile Gly Pro His Leu Gln 
            500                 505                 510         


Ser Met Pro Ser Glu Gln Ile Arg Asn Gln Leu Thr Ala Met Ser Ser 
        515                 520                 525             


Val Leu Ala Lys Ala Leu Glu Val Ile Lys Pro Ala His Ile Leu Gln 
    530                 535                 540                 


Glu Lys Glu Glu Gln His Gln Leu Ala Val Thr Ala Tyr Leu Lys Asn 
545                 550                 555                 560 


Ser Arg Lys Glu His Gln Arg Ile Leu Ala Arg Arg Gln Thr Ile Glu 
                565                 570                 575     


Glu Arg Lys Glu Arg Leu Glu Ser Leu Asn Ile Gln Arg Glu Lys Glu 
            580                 585                 590         


Glu Leu Glu Gln Arg Glu Ala Glu Leu Gln Lys Val Arg Lys Ala Glu 
        595                 600                 605             


Glu Glu Arg Leu Arg Gln Glu Ala Lys Glu Arg Glu Lys Glu Arg Ile 
    610                 615                 620                 


Leu Gln Glu His Glu Gln Ile Lys Lys Lys Thr Val Arg Glu Arg Leu 
625                 630                 635                 640 


Glu Gln Ile Lys Lys Thr Glu Leu Gly Ala Lys Ala Phe Lys Asp Ile 
                645                 650                 655     


Asp Ile Glu Asp Leu Glu Glu Leu Asp Pro Asp Phe Ile Met Ala Lys 
            660                 665                 670         


Gln Val Glu Gln Leu Glu Lys Glu Lys Lys Glu Leu Gln Glu Arg Leu 
        675                 680                 685             


Lys Asn Gln Glu Lys Lys Ile Asp Tyr Phe Glu Arg Ala Lys Arg Leu 
    690                 695                 700                 


Glu Glu Ile Pro Leu Ile Lys Ser Ala Tyr Glu Glu Gln Arg Ile Lys 
705                 710                 715                 720 


Asp Met Asp Leu Trp Glu Gln Gln Glu Glu Glu Arg Ile Thr Thr Met 
                725                 730                 735     


Gln Leu Glu Arg Glu Lys Ala Leu Glu His Lys Asn Arg Met Ser Arg 
            740                 745                 750         


Met Leu Glu Asp Arg Asp Leu Phe Val Met Arg Leu Lys Ala Ala Arg 
        755                 760                 765             


Gln Ser Val Tyr Glu Glu Lys Leu Lys Gln Phe Glu Glu Arg Leu Ala 
    770                 775                 780                 


Glu Glu Arg His Asn Arg Leu Glu Glu Arg Lys Arg Gln Arg Lys Glu 
785                 790                 795                 800 


Glu Arg Arg Ile Thr Tyr Tyr Arg Glu Lys Glu Glu Glu Glu Gln Arg 
                805                 810                 815     


Arg Ala Glu Glu Gln Met Leu Lys Glu Arg Glu Glu Arg Glu Arg Ala 
            820                 825                 830         


Glu Arg Ala Lys Arg Glu Glu Glu Leu Arg Glu Tyr Gln Glu Arg Val 
        835                 840                 845             


Lys Lys Leu Glu Glu Val Glu Arg Lys Lys Arg Gln Arg Glu Leu Glu 
    850                 855                 860                 


Ile Glu Glu Arg Glu Arg Arg Arg Glu Glu Glu Arg Arg Leu Gly Asp 
865                 870                 875                 880 


Ser Ser Leu Ser Arg Lys Asp Ser Arg Trp Gly Asp Arg Asp Ser Glu 
                885                 890                 895     


Gly Thr Trp Arg Lys Gly Pro Glu Ala Asp Ser Glu Trp Arg Arg Gly 
            900                 905                 910         


Pro Pro Glu Lys Glu Trp Arg Arg Gly Glu Gly Arg Asp Glu Asp Arg 
        915                 920                 925             


Ser His Arg Arg Asp Glu Glu Arg Pro Arg Arg Leu Gly Asp Asp Glu 
    930                 935                 940                 


Asp Arg Glu Pro Ser Leu Arg Pro Asp Asp Asp Arg Val Pro Arg Arg 
945                 950                 955                 960 


Gly Met Asp Asp Asp Arg Gly Pro Arg Arg Gly Pro Glu Glu Asp Arg 
                965                 970                 975     


Phe Ser Arg Arg Gly Ala Asp Asp Asp Arg Pro Ser Trp Arg Asn Thr 
            980                 985                 990         


Asp Asp Asp Arg Pro Pro Arg Arg  Ile Ala Asp Glu Asp  Arg Gly Asn 
        995                 1000                 1005             


Trp Arg  His Ala Asp Asp Asp  Arg Pro Pro Arg Arg  Gly Leu Asp 
    1010                 1015                 1020             


Glu Asp  Arg Gly Ser Trp Arg  Thr Ala Asp Glu Asp  Arg Gly Pro 
    1025                 1030                 1035             


Arg Arg  Gly Met Asp Asp Asp  Arg Gly Pro Arg Arg  Gly Gly Ala 
    1040                 1045                 1050             


Asp Asp  Glu Arg Ser Ser Trp  Arg Asn Ala Asp Asp  Asp Arg Gly 
    1055                 1060                 1065             


Pro Arg  Arg Gly Leu Asp Asp  Asp Arg Gly Pro Arg  Arg Gly Met 
    1070                 1075                 1080             


Asp Asp  Asp Arg Gly Pro Arg  Arg Gly Met Asp Asp  Asp Arg Gly 
    1085                 1090                 1095             


Pro Arg  Arg Gly Met Asp Asp  Asp Arg Gly Pro Arg  Arg Gly Leu 
    1100                 1105                 1110             


Asp Asp  Asp Arg Gly Pro Trp  Arg Asn Ala Asp Asp  Asp Arg Ile 
    1115                 1120                 1125             


Pro Arg  Arg Gly Ala Glu Asp  Asp Arg Gly Pro Trp  Arg Asn Met 
    1130                 1135                 1140             


Asp Asp  Asp Arg Leu Ser Arg  Arg Ala Asp Asp Asp  Arg Phe Pro 
    1145                 1150                 1155             


Arg Arg  Gly Asp Asp Ser Arg  Pro Gly Pro Trp Arg  Pro Leu Val 
    1160                 1165                 1170             


Lys Pro  Gly Gly Trp Arg Glu  Lys Glu Lys Ala Arg  Glu Glu Ser 
    1175                 1180                 1185             


Trp Gly  Pro Pro Arg Glu Ser  Arg Pro Ser Glu Glu  Arg Glu Trp 
    1190                 1195                 1200             


Asp Arg  Glu Lys Glu Arg Asp  Arg Asp Asn Gln Asp  Arg Glu Glu 
    1205                 1210                 1215             


Asn Asp  Lys Asp Pro Glu Arg  Glu Arg Asp Arg Glu  Arg Asp Val 
    1220                 1225                 1230             


Asp Arg  Glu Asp Arg Phe Arg  Arg Pro Arg Asp Glu  Gly Gly Trp 
    1235                 1240                 1245             


Arg Arg  Gly Pro Ala Glu Glu  Ser Ser Ser Trp Arg  Asp Ser Ser 
    1250                 1255                 1260             


Arg Arg  Asp Asp Arg Asp Arg  Asp Asp Arg Arg Arg  Glu Arg Asp 
    1265                 1270                 1275             


Asp Arg  Arg Asp Leu Arg Glu  Arg Arg Asp Leu Arg  Asp Asp Arg 
    1280                 1285                 1290             


Asp Arg  Arg Gly Pro Pro Leu  Arg Ser Glu Arg Glu  Glu Val Ser 
    1295                 1300                 1305             


Ser Trp  Arg Arg Ala Asp Asp  Arg Lys Asp Asp Arg  Val Glu Glu 
    1310                 1315                 1320             


Arg Asp  Pro Pro Arg Arg Val  Pro Pro Pro Ala Leu  Ser Arg Asp 
    1325                 1330                 1335             


Arg Glu  Arg Asp Arg Asp Arg  Glu Arg Glu Gly Glu  Lys Glu Lys 
    1340                 1345                 1350             


Ala Ser  Trp Arg Ala Glu Lys  Asp Arg Glu Ser Leu  Arg Arg Thr 
    1355                 1360                 1365             


Lys Asn  Glu Thr Asp Glu Asp  Gly Trp Thr Thr Val  Arg Arg 
    1370                 1375                 1380         


<210>  3464
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3B__Homo_sapiens__NP_001032360

<400>  3464

Met Gln Asp Ala Glu Asn Val Ala Val Pro Glu Ala Ala Glu Glu Arg 
1               5                   10                  15      


Ala Glu Pro Gly Gln Gln Gln Pro Ala Ala Glu Pro Pro Pro Ala Glu 
            20                  25                  30          


Gly Leu Leu Arg Pro Ala Gly Pro Gly Ala Pro Glu Ala Ala Gly Thr 
        35                  40                  45              


Glu Ala Ser Ser Glu Glu Val Gly Ile Ala Glu Ala Gly Pro Glu Ser 
    50                  55                  60                  


Glu Val Arg Thr Glu Pro Ala Ala Glu Ala Glu Ala Ala Ser Gly Pro 
65                  70                  75                  80  


Ser Glu Ser Pro Ser Pro Pro Ala Ala Glu Glu Leu Pro Gly Ser His 
                85                  90                  95      


Ala Glu Pro Pro Val Pro Ala Gln Gly Glu Ala Pro Gly Glu Gln Ala 
            100                 105                 110         


Arg Asp Glu Arg Ser Asp Ser Arg Ala Gln Ala Val Ser Glu Asp Ala 
        115                 120                 125             


Gly Gly Asn Glu Gly Arg Ala Ala Glu Ala Glu Pro Arg Ala Leu Glu 
    130                 135                 140                 


Asn Gly Asp Ala Asp Glu Pro Ser Phe Ser Asp Pro Glu Asp Phe Val 
145                 150                 155                 160 


Asp Asp Val Ser Glu Glu Glu Leu Leu Gly Asp Val Leu Lys Asp Arg 
                165                 170                 175     


Pro Gln Glu Ala Asp Gly Ile Asp Ser Val Ile Val Val Asp Asn Val 
            180                 185                 190         


Pro Gln Val Gly Pro Asp Arg Leu Glu Lys Leu Lys Asn Val Ile His 
        195                 200                 205             


Lys Ile Phe Ser Lys Phe Gly Lys Ile Thr Asn Asp Phe Tyr Pro Glu 
    210                 215                 220                 


Glu Asp Gly Lys Thr Lys Gly Tyr Ile Phe Leu Glu Tyr Ala Ser Pro 
225                 230                 235                 240 


Ala His Ala Val Asp Ala Val Lys Asn Ala Asp Gly Tyr Lys Leu Asp 
                245                 250                 255     


Lys Gln His Thr Phe Arg Val Asn Leu Phe Thr Asp Phe Asp Lys Tyr 
            260                 265                 270         


Met Thr Ile Ser Asp Glu Trp Asp Ile Pro Glu Lys Gln Pro Phe Lys 
        275                 280                 285             


Asp Leu Gly Asn Leu Arg Tyr Trp Leu Glu Glu Ala Glu Cys Arg Asp 
    290                 295                 300                 


Gln Tyr Ser Val Ile Phe Glu Ser Gly Asp Arg Thr Ser Ile Phe Trp 
305                 310                 315                 320 


Asn Asp Val Lys Asp Pro Val Ser Ile Glu Glu Arg Ala Arg Trp Thr 
                325                 330                 335     


Glu Thr Tyr Val Arg Trp Ser Pro Lys Gly Thr Tyr Leu Ala Thr Phe 
            340                 345                 350         


His Gln Arg Gly Ile Ala Leu Trp Gly Gly Glu Lys Phe Lys Gln Ile 
        355                 360                 365             


Gln Arg Phe Ser His Gln Gly Val Gln Leu Ile Asp Phe Ser Pro Cys 
    370                 375                 380                 


Glu Arg Tyr Leu Val Thr Phe Ser Pro Leu Met Asp Thr Gln Asp Asp 
385                 390                 395                 400 


Pro Gln Ala Ile Ile Ile Trp Asp Ile Leu Thr Gly His Lys Lys Arg 
                405                 410                 415     


Gly Phe His Cys Glu Ser Ser Ala His Trp Pro Ile Phe Lys Trp Ser 
            420                 425                 430         


His Asp Gly Lys Phe Phe Ala Arg Met Thr Leu Asp Thr Leu Ser Ile 
        435                 440                 445             


Tyr Glu Thr Pro Ser Met Gly Leu Leu Asp Lys Lys Ser Leu Lys Ile 
    450                 455                 460                 


Ser Gly Ile Lys Asp Phe Ser Trp Ser Pro Gly Gly Asn Ile Ile Ala 
465                 470                 475                 480 


Phe Trp Val Pro Glu Asp Lys Asp Ile Pro Ala Arg Val Thr Leu Met 
                485                 490                 495     


Gln Leu Pro Thr Arg Gln Glu Ile Arg Val Arg Asn Leu Phe Asn Val 
            500                 505                 510         


Val Asp Cys Lys Leu His Trp Gln Lys Asn Gly Asp Tyr Leu Cys Val 
        515                 520                 525             


Lys Val Asp Arg Thr Pro Lys Gly Thr Gln Gly Val Val Thr Asn Phe 
    530                 535                 540                 


Glu Ile Phe Arg Met Arg Glu Lys Gln Val Pro Val Asp Val Val Glu 
545                 550                 555                 560 


Met Lys Glu Thr Ile Ile Ala Phe Ala Trp Glu Pro Asn Gly Ser Lys 
                565                 570                 575     


Phe Ala Val Leu His Gly Glu Ala Pro Arg Ile Ser Val Ser Phe Tyr 
            580                 585                 590         


His Val Lys Asn Asn Gly Lys Ile Glu Leu Ile Lys Met Phe Asp Lys 
        595                 600                 605             


Gln Gln Ala Asn Thr Ile Phe Trp Ser Pro Gln Gly Gln Phe Val Val 
    610                 615                 620                 


Leu Ala Gly Leu Arg Ser Met Asn Gly Ala Leu Ala Phe Val Asp Thr 
625                 630                 635                 640 


Ser Asp Cys Thr Val Met Asn Ile Ala Glu His Tyr Met Ala Ser Asp 
                645                 650                 655     


Val Glu Trp Asp Pro Thr Gly Arg Tyr Val Val Thr Ser Val Ser Trp 
            660                 665                 670         


Trp Ser His Lys Val Asp Asn Ala Tyr Trp Leu Trp Thr Phe Gln Gly 
        675                 680                 685             


Arg Leu Leu Gln Lys Asn Asn Lys Asp Arg Phe Cys Gln Leu Leu Trp 
    690                 695                 700                 


Arg Pro Arg Pro Pro Thr Leu Leu Ser Gln Glu Gln Ile Lys Gln Ile 
705                 710                 715                 720 


Lys Lys Asp Leu Lys Lys Tyr Ser Lys Ile Phe Glu Gln Lys Asp Arg 
                725                 730                 735     


Leu Ser Gln Ser Lys Ala Ser Lys Glu Leu Val Glu Arg Arg Arg Thr 
            740                 745                 750         


Met Met Glu Asp Phe Arg Lys Tyr Arg Lys Met Ala Gln Glu Leu Tyr 
        755                 760                 765             


Met Glu Gln Lys Asn Glu Arg Leu Glu Leu Arg Gly Gly Val Asp Thr 
    770                 775                 780                 


Asp Glu Leu Asp Ser Asn Val Asp Asp Trp Glu Glu Glu Thr Ile Glu 
785                 790                 795                 800 


Phe Phe Val Thr Glu Glu Ile Ile Pro Leu Gly Asn Gln Glu 
                805                 810                 


<210>  3465
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3C__Homo_sapiens__NP_001254503

<400>  3465

Met Ser Arg Phe Phe Thr Thr Gly Ser Asp Ser Glu Ser Glu Ser Ser 
1               5                   10                  15      


Leu Ser Gly Glu Glu Leu Val Thr Lys Pro Val Gly Gly Asn Tyr Gly 
            20                  25                  30          


Lys Gln Pro Leu Leu Leu Ser Glu Asp Glu Glu Asp Thr Lys Arg Val 
        35                  40                  45              


Val Arg Ser Ala Lys Asp Lys Arg Phe Glu Glu Leu Thr Asn Leu Ile 
    50                  55                  60                  


Arg Thr Ile Arg Asn Ala Met Lys Ile Arg Asp Val Thr Lys Cys Leu 
65                  70                  75                  80  


Glu Glu Phe Glu Leu Leu Gly Lys Ala Tyr Gly Lys Ala Lys Ser Ile 
                85                  90                  95      


Val Asp Lys Glu Gly Val Pro Arg Phe Tyr Ile Arg Ile Leu Ala Asp 
            100                 105                 110         


Leu Glu Asp Tyr Leu Asn Glu Leu Trp Glu Asp Lys Glu Gly Lys Lys 
        115                 120                 125             


Lys Met Asn Lys Asn Asn Ala Lys Ala Leu Ser Thr Leu Arg Gln Lys 
    130                 135                 140                 


Ile Arg Lys Tyr Asn Arg Asp Phe Glu Ser His Ile Thr Ser Tyr Lys 
145                 150                 155                 160 


Gln Asn Pro Glu Gln Ser Ala Asp Glu Asp Ala Glu Lys Asn Glu Glu 
                165                 170                 175     


Asp Ser Glu Gly Ser Ser Asp Glu Asp Glu Asp Glu Asp Gly Val Ser 
            180                 185                 190         


Ala Ala Thr Phe Leu Lys Lys Lys Ser Glu Ala Pro Ser Gly Glu Ser 
        195                 200                 205             


Arg Lys Phe Leu Lys Lys Met Asp Asp Glu Asp Glu Asp Ser Glu Asp 
    210                 215                 220                 


Ser Glu Asp Asp Glu Asp Trp Asp Thr Gly Ser Thr Ser Ser Asp Ser 
225                 230                 235                 240 


Asp Ser Glu Glu Glu Glu Gly Lys Gln Thr Ala Leu Ala Ser Arg Phe 
                245                 250                 255     


Leu Lys Lys Ala Pro Thr Thr Asp Glu Asp Lys Lys Ala Ala Glu Lys 
            260                 265                 270         


Lys Arg Glu Asp Lys Ala Lys Lys Lys His Asp Arg Lys Ser Lys Arg 
        275                 280                 285             


Leu Asp Glu Glu Glu Glu Asp Asn Glu Gly Gly Glu Trp Glu Arg Val 
    290                 295                 300                 


Arg Gly Gly Val Pro Leu Val Lys Glu Lys Pro Lys Met Phe Ala Lys 
305                 310                 315                 320 


Gly Thr Glu Ile Thr His Ala Val Val Ile Lys Lys Leu Asn Glu Ile 
                325                 330                 335     


Leu Gln Ala Arg Gly Lys Lys Gly Thr Asp Arg Ala Ala Gln Ile Glu 
            340                 345                 350         


Leu Leu Gln Leu Leu Val Gln Ile Ala Ala Glu Asn Asn Leu Gly Glu 
        355                 360                 365             


Gly Val Ile Val Lys Ile Lys Phe Asn Ile Ile Ala Ser Leu Tyr Asp 
    370                 375                 380                 


Tyr Asn Pro Asn Leu Ala Thr Tyr Met Lys Pro Glu Met Trp Gly Lys 
385                 390                 395                 400 


Cys Leu Asp Cys Ile Asn Glu Leu Met Asp Ile Leu Phe Ala Asn Pro 
                405                 410                 415     


Asn Ile Phe Val Gly Glu Asn Ile Leu Glu Glu Ser Glu Asn Leu His 
            420                 425                 430         


Asn Ala Asp Gln Pro Leu Arg Val Arg Gly Cys Ile Leu Thr Leu Val 
        435                 440                 445             


Glu Arg Met Asp Glu Glu Phe Thr Lys Ile Met Gln Asn Thr Asp Pro 
    450                 455                 460                 


His Ser Gln Glu Tyr Val Glu His Leu Lys Asp Glu Ala Gln Val Cys 
465                 470                 475                 480 


Ala Ile Ile Glu Arg Val Gln Arg Tyr Leu Glu Glu Lys Gly Thr Thr 
                485                 490                 495     


Glu Glu Val Cys Arg Ile Tyr Leu Leu Arg Ile Leu His Thr Tyr Tyr 
            500                 505                 510         


Lys Phe Asp Tyr Lys Ala His Gln Arg Gln Leu Thr Pro Pro Glu Gly 
        515                 520                 525             


Ser Ser Lys Ser Glu Gln Asp Gln Ala Glu Asn Glu Gly Glu Asp Ser 
    530                 535                 540                 


Ala Val Leu Met Glu Arg Leu Cys Lys Tyr Ile Tyr Ala Lys Asp Arg 
545                 550                 555                 560 


Thr Asp Arg Ile Arg Thr Cys Ala Ile Leu Cys His Ile Tyr His His 
                565                 570                 575     


Ala Leu His Ser Arg Trp Tyr Gln Ala Arg Asp Leu Met Leu Met Ser 
            580                 585                 590         


His Leu Gln Asp Asn Ile Gln His Ala Asp Pro Pro Val Gln Ile Leu 
        595                 600                 605             


Tyr Asn Arg Thr Met Val Gln Leu Gly Ile Cys Ala Phe Arg Gln Gly 
    610                 615                 620                 


Leu Thr Lys Asp Ala His Asn Ala Leu Leu Asp Ile Gln Ser Ser Gly 
625                 630                 635                 640 


Arg Ala Lys Glu Leu Leu Gly Gln Gly Leu Leu Leu Arg Ser Leu Gln 
                645                 650                 655     


Glu Arg Asn Gln Glu Gln Glu Lys Val Glu Arg Arg Arg Gln Val Pro 
            660                 665                 670         


Phe His Leu His Ile Asn Leu Glu Leu Leu Glu Cys Val Tyr Leu Val 
        675                 680                 685             


Ser Ala Met Leu Leu Glu Ile Pro Tyr Met Ala Ala His Glu Ser Asp 
    690                 695                 700                 


Ala Arg Arg Arg Met Ile Ser Lys Gln Phe His His Gln Leu Arg Val 
705                 710                 715                 720 


Gly Glu Arg Gln Pro Leu Leu Gly Pro Pro Glu Ser Met Arg Glu His 
                725                 730                 735     


Val Val Ala Ala Ser Lys Ala Met Lys Met Gly Asp Trp Lys Thr Cys 
            740                 745                 750         


His Ser Phe Ile Ile Asn Glu Lys Met Asn Gly Lys Val Trp Asp Leu 
        755                 760                 765             


Phe Pro Glu Ala Asp Lys Val Arg Thr Met Leu Val Arg Lys Ile Gln 
    770                 775                 780                 


Glu Glu Ser Leu Arg Thr Tyr Leu Phe Thr Tyr Ser Ser Val Tyr Asp 
785                 790                 795                 800 


Ser Ile Ser Met Glu Thr Leu Ser Asp Met Phe Glu Leu Asp Leu Pro 
                805                 810                 815     


Thr Val His Ser Ile Ile Ser Lys Met Ile Ile Asn Glu Glu Leu Met 
            820                 825                 830         


Ala Ser Leu Asp Gln Pro Thr Gln Thr Val Val Met His Arg Thr Glu 
        835                 840                 845             


Pro Thr Ala Gln Gln Asn Leu Ala Leu Gln Leu Ala Glu Lys Leu Gly 
    850                 855                 860                 


Ser Leu Val Glu Asn Asn Glu Arg Val Phe Asp His Lys Gln Gly Thr 
865                 870                 875                 880 


Tyr Gly Gly Tyr Phe Arg Asp Gln Lys Asp Gly Tyr Arg Lys Asn Glu 
                885                 890                 895     


Gly Tyr Met Arg Arg Gly Gly Tyr Arg Gln Gln Gln Ser Gln Thr Ala 
            900                 905                 910         


Tyr 
    


<210>  3466
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3E__Homo_sapiens__NP_001559

<400>  3466

Met Ala Glu Tyr Asp Leu Thr Thr Arg Ile Ala His Phe Leu Asp Arg 
1               5                   10                  15      


His Leu Val Phe Pro Leu Leu Glu Phe Leu Ser Val Lys Glu Ile Tyr 
            20                  25                  30          


Asn Glu Lys Glu Leu Leu Gln Gly Lys Leu Asp Leu Leu Ser Asp Thr 
        35                  40                  45              


Asn Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp 
    50                  55                  60                  


Asp Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln 
65                  70                  75                  80  


Leu Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu 
                85                  90                  95      


Asp Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met 
            100                 105                 110         


Leu Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu 
        115                 120                 125             


Asp Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr 
    130                 135                 140                 


Ser Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala 
145                 150                 155                 160 


Thr Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu 
                165                 170                 175     


Ile Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu 
            180                 185                 190         


Lys Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu 
        195                 200                 205             


Gln Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn 
    210                 215                 220                 


His Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro 
225                 230                 235                 240 


Gln Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr 
                245                 250                 255     


Leu Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln 
            260                 265                 270         


Val Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr 
        275                 280                 285             


Lys Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp 
    290                 295                 300                 


Phe Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val 
305                 310                 315                 320 


Asn Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala 
                325                 330                 335     


Arg Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser 
            340                 345                 350         


Ile Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu 
        355                 360                 365             


Arg Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile 
    370                 375                 380                 


Asp Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro 
385                 390                 395                 400 


Tyr Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln 
                405                 410                 415     


Met Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser 
            420                 425                 430         


Glu Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr 
        435                 440                 445 


<210>  3467
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3F__Homo_sapiens__NP_003745

<400>  3467

Met Ala Thr Pro Ala Val Pro Val Ser Ala Pro Pro Ala Thr Pro Thr 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Pro Ala Ser Val Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ala Ala Pro Val Pro Ala Ala Ala Pro Ala Ser Ser Ser Asp 
        35                  40                  45              


Pro Ala Ala Ala Ala Ala Ala Thr Ala Ala Pro Gly Gln Thr Pro Ala 
    50                  55                  60                  


Ser Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro Ala Leu Pro Gly Pro 
65                  70                  75                  80  


Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val Val Arg Leu His Pro 
                85                  90                  95      


Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu Arg Arg Asn Glu Gly 
            100                 105                 110         


Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr Val Asp Lys His Ser 
        115                 120                 125             


Val Glu Val Thr Asn Cys Phe Ser Val Pro His Asn Glu Ser Glu Asp 
    130                 135                 140                 


Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn Met Tyr Glu Leu His 
145                 150                 155                 160 


Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly Trp Tyr Ala Thr Gly 
                165                 170                 175     


His Asp Ile Thr Glu His Ser Val Leu Ile His Glu Tyr Tyr Ser Arg 
            180                 185                 190         


Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp Thr Ser Leu Gln Asn 
        195                 200                 205             


Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr Leu Met Gly Val Pro 
    210                 215                 220                 


Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu Thr Val Lys Tyr Ala 
225                 230                 235                 240 


Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu Ile Met Lys Thr Cys 
                245                 250                 255     


Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser Asp Leu Gln Gln Val 
            260                 265                 270         


Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu Ser Thr Val Leu Gln 
        275                 280                 285             


Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser Ala Asp Asn Thr Val 
    290                 295                 300                 


Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val Pro Lys Ile Val Pro 
305                 310                 315                 320 


Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile Asn Asp Leu Leu Met 
                325                 330                 335     


Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile Ala Leu Asn Glu 
            340                 345                 350         


Lys Leu Val Asn Leu 
        355         


<210>  3468
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3H__Homo_sapiens__NP_003747

<400>  3468

Met Ala Ser Arg Lys Glu Gly Thr Gly Ser Thr Ala Thr Ser Ser Ser 
1               5                   10                  15      


Ser Thr Ala Gly Ala Ala Gly Lys Gly Lys Gly Lys Gly Gly Ser Gly 
            20                  25                  30          


Asp Ser Ala Val Lys Gln Val Gln Ile Asp Gly Leu Val Val Leu Lys 
        35                  40                  45              


Ile Ile Lys His Tyr Gln Glu Glu Gly Gln Gly Thr Glu Val Val Gln 
    50                  55                  60                  


Gly Val Leu Leu Gly Leu Val Val Glu Asp Arg Leu Glu Ile Thr Asn 
65                  70                  75                  80  


Cys Phe Pro Phe Pro Gln His Thr Glu Asp Asp Ala Asp Phe Asp Glu 
                85                  90                  95      


Val Gln Tyr Gln Met Glu Met Met Arg Ser Leu Arg His Val Asn Ile 
            100                 105                 110         


Asp His Leu His Val Gly Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe 
        115                 120                 125             


Val Thr Arg Ala Leu Leu Asp Ser Gln Phe Ser Tyr Gln His Ala Ile 
    130                 135                 140                 


Glu Glu Ser Val Val Leu Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly 
145                 150                 155                 160 


Ser Leu Ser Leu Lys Ala Tyr Arg Leu Thr Pro Lys Leu Met Glu Val 
                165                 170                 175     


Cys Lys Glu Lys Asp Phe Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile 
            180                 185                 190         


Thr Phe Glu Tyr Met Phe Glu Glu Val Pro Ile Val Ile Lys Asn Ser 
        195                 200                 205             


His Leu Ile Asn Val Leu Met Trp Glu Leu Glu Lys Lys Ser Ala Val 
    210                 215                 220                 


Ala Asp Lys His Glu Leu Leu Ser Leu Ala Ser Ser Asn His Leu Gly 
225                 230                 235                 240 


Lys Asn Leu Gln Leu Leu Met Asp Arg Val Asp Glu Met Ser Gln Asp 
                245                 250                 255     


Ile Val Lys Tyr Asn Thr Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln 
            260                 265                 270         


Gln Lys His Gln Tyr Gln Gln Arg Arg Gln Gln Glu Asn Met Gln Arg 
        275                 280                 285             


Gln Ser Arg Gly Glu Pro Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu 
    290                 295                 300                 


Phe Lys Pro Pro Gln Pro Pro Ala Arg Met Asp Ser Leu Leu Ile Ala 
305                 310                 315                 320 


Gly Gln Ile Asn Thr Tyr Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln 
                325                 330                 335     


Asn Leu Gly Lys Leu Phe Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
            340                 345                 350         


<210>  3469
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3J__Homo_sapiens__NP_001271265

<400>  3469

Met Ala Ala Ala Ala Ala Ala Ala Gly Asp Ser Asp Ser Trp Asp Ala 
1               5                   10                  15      


Asp Ala Phe Ser Val Glu Asp Pro Val Arg Lys Val Gly Gly Gly Gly 
            20                  25                  30          


Thr Ala Gly Gly Asp Arg Trp Glu Gly Glu Asp Glu Asp Glu Asp Val 
        35                  40                  45              


Lys Leu Glu Glu Pro Glu Glu Pro Lys Val Leu Thr Pro Glu Glu Gln 
    50                  55                  60                  


Leu Ala Asp Lys Leu Arg Leu Lys Lys Leu Gln Glu Glu Ser Asp Leu 
65                  70                  75                  80  


Glu Leu Ala Lys Glu Thr Phe Gly Val Asn Asn Ala Val Tyr Gly Ile 
                85                  90                  95      


Asp Ala Met Asn Pro Ser Ser Arg Asp Asp Phe Thr Glu Phe Gly Lys 
            100                 105                 110         


Leu Leu Lys Asp Lys Ile Thr Gln Tyr Glu Lys Ser Leu Tyr Tyr Ala 
        115                 120                 125             


Ser Phe Leu Glu Val Leu Val Arg Asp Val Cys Ile Ser Leu Glu Ile 
    130                 135                 140                 


Asp Asp Leu Lys Lys Ile Thr Asn Ser Leu Thr Val Leu Cys Ser Glu 
145                 150                 155                 160 


Lys Gln Lys Gln Glu Lys Gln Ser Lys Ala Lys Lys Lys Lys Lys Gly 
                165                 170                 175     


Val Val Pro Gly Gly Gly Leu Lys Ala Thr Met Lys Asp Asp Leu Ala 
            180                 185                 190         


Asp Tyr Gly Gly Tyr Asp Gly Gly Tyr Val Gln Asp Tyr Glu Asp Phe 
        195                 200                 205             


Met 
    


<210>  3470
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3K__Homo_sapiens__NP_037366

<400>  3470

Met Ala Met Phe Glu Gln Met Arg Ala Asn Val Gly Lys Leu Leu Lys 
1               5                   10                  15      


Gly Ile Asp Arg Tyr Asn Pro Glu Asn Leu Ala Thr Leu Glu Arg Tyr 
            20                  25                  30          


Val Glu Thr Gln Ala Lys Glu Asn Ala Tyr Asp Leu Glu Ala Asn Leu 
        35                  40                  45              


Ala Val Leu Lys Leu Tyr Gln Phe Asn Pro Ala Phe Phe Gln Thr Thr 
    50                  55                  60                  


Val Thr Ala Gln Ile Leu Leu Lys Ala Leu Thr Asn Leu Pro His Thr 
65                  70                  75                  80  


Asp Phe Thr Leu Cys Lys Cys Met Ile Asp Gln Ala His Gln Glu Glu 
                85                  90                  95      


Arg Pro Ile Arg Gln Ile Leu Tyr Leu Gly Asp Leu Leu Glu Thr Cys 
            100                 105                 110         


His Phe Gln Ala Phe Trp Gln Ala Leu Asp Glu Asn Met Asp Leu Leu 
        115                 120                 125             


Glu Gly Ile Thr Gly Phe Glu Asp Ser Val Arg Lys Phe Ile Cys His 
    130                 135                 140                 


Val Val Gly Ile Thr Tyr Gln His Ile Asp Arg Trp Leu Leu Ala Glu 
145                 150                 155                 160 


Met Leu Gly Asp Leu Ser Asp Ser Gln Leu Lys Val Trp Met Ser Lys 
                165                 170                 175     


Tyr Gly Trp Ser Ala Asp Glu Ser Gly Gln Ile Phe Ile Cys Ser Gln 
            180                 185                 190         


Glu Glu Ser Ile Lys Pro Lys Asn Ile Val Glu Lys Ile Asp Phe Asp 
        195                 200                 205             


Ser Val Ser Ser Ile Met Ala Ser Ser Gln 
    210                 215             


<210>  3471
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF3M__Homo_sapiens__NP_006351

<400>  3471

Met Ser Val Pro Ala Phe Ile Asp Ile Ser Glu Glu Asp Gln Ala Ala 
1               5                   10                  15      


Glu Leu Arg Ala Tyr Leu Lys Ser Lys Gly Ala Glu Ile Ser Glu Glu 
            20                  25                  30          


Asn Ser Glu Gly Gly Leu His Val Asp Leu Ala Gln Ile Ile Glu Ala 
        35                  40                  45              


Cys Asp Val Cys Leu Lys Glu Asp Asp Lys Asp Val Glu Ser Val Met 
    50                  55                  60                  


Asn Ser Val Val Ser Leu Leu Leu Ile Leu Glu Pro Asp Lys Gln Glu 
65                  70                  75                  80  


Ala Leu Ile Glu Ser Leu Cys Glu Lys Leu Val Lys Phe Arg Glu Gly 
                85                  90                  95      


Glu Arg Pro Ser Leu Arg Leu Gln Leu Leu Ser Asn Leu Phe His Gly 
            100                 105                 110         


Met Asp Lys Asn Thr Pro Val Arg Tyr Thr Val Tyr Cys Ser Leu Ile 
        115                 120                 125             


Lys Val Ala Ala Ser Cys Gly Ala Ile Gln Tyr Ile Pro Thr Glu Leu 
    130                 135                 140                 


Asp Gln Val Arg Lys Trp Ile Ser Asp Trp Asn Leu Thr Thr Glu Lys 
145                 150                 155                 160 


Lys His Thr Leu Leu Arg Leu Leu Tyr Glu Ala Leu Val Asp Cys Lys 
                165                 170                 175     


Lys Ser Asp Ala Ala Ser Lys Val Met Val Glu Leu Leu Gly Ser Tyr 
            180                 185                 190         


Thr Glu Asp Asn Ala Ser Gln Ala Arg Val Asp Ala His Arg Cys Ile 
        195                 200                 205             


Val Arg Ala Leu Lys Asp Pro Asn Ala Phe Leu Phe Asp His Leu Leu 
    210                 215                 220                 


Thr Leu Lys Pro Val Lys Phe Leu Glu Gly Glu Leu Ile His Asp Leu 
225                 230                 235                 240 


Leu Thr Ile Phe Val Ser Ala Lys Leu Ala Ser Tyr Val Lys Phe Tyr 
                245                 250                 255     


Gln Asn Asn Lys Asp Phe Ile Asp Ser Leu Gly Leu Leu His Glu Gln 
            260                 265                 270         


Asn Met Ala Lys Met Arg Leu Leu Thr Phe Met Gly Met Ala Val Glu 
        275                 280                 285             


Asn Lys Glu Ile Ser Phe Asp Thr Met Gln Gln Glu Leu Gln Ile Gly 
    290                 295                 300                 


Ala Asp Asp Val Glu Ala Phe Val Ile Asp Ala Val Arg Thr Lys Met 
305                 310                 315                 320 


Val Tyr Cys Lys Ile Asp Gln Thr Gln Arg Lys Val Val Val Ser His 
                325                 330                 335     


Ser Thr His Arg Thr Phe Gly Lys Gln Gln Trp Gln Gln Leu Tyr Asp 
            340                 345                 350         


Thr Leu Asn Ala Trp Lys Gln Asn Leu Asn Lys Val Lys Asn Ser Leu 
        355                 360                 365             


Leu Ser Leu Ser Asp Thr 
    370                 


<210>  3472
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4A1__Homo_sapiens__NP_001191439

<400>  3472

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Gly Lys Leu Tyr 
                325                 330                 335     


Pro Gln Asn Arg Ser Arg Trp Thr Val Trp Pro 
            340                 345         


<210>  3473
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4A2__Homo_sapiens__NP_001958

<400>  3473

Met Ser Gly Gly Ser Ala Asp Tyr Asn Arg Glu His Gly Gly Pro Glu 
1               5                   10                  15      


Gly Met Asp Pro Asp Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val 
            20                  25                  30          


Asp Asn Phe Asp Asp Met Asn Leu Lys Glu Ser Leu Leu Arg Gly Ile 
        35                  40                  45              


Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile 
    50                  55                  60                  


Ile Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly 
65                  70                  75                  80  


Thr Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Leu Glu 
                85                  90                  95      


Ile Glu Phe Lys Glu Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu 
            100                 105                 110         


Leu Ala Gln Gln Ile Gln Lys Val Ile Leu Ala Leu Gly Asp Tyr Met 
        115                 120                 125             


Gly Ala Thr Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Asn Glu 
    130                 135                 140                 


Met Gln Lys Leu Gln Ala Glu Ala Pro His Ile Val Val Gly Thr Pro 
145                 150                 155                 160 


Gly Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Trp 
                165                 170                 175     


Ile Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly 
            180                 185                 190         


Phe Lys Asp Gln Ile Tyr Glu Ile Phe Gln Lys Leu Asn Thr Ser Ile 
        195                 200                 205             


Gln Val Val Leu Leu Ser Ala Thr Met Pro Thr Asp Val Leu Glu Val 
    210                 215                 220                 


Thr Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu 
225                 230                 235                 240 


Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Tyr Ile Asn Val Glu Arg 
                245                 250                 255     


Glu Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr 
            260                 265                 270         


Ile Thr Gln Ala Val Ile Phe Leu Asn Thr Arg Arg Lys Val Asp Trp 
        275                 280                 285             


Leu Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Leu His 
    290                 295                 300                 


Gly Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg 
305                 310                 315                 320 


Ser Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly 
                325                 330                 335     


Ile Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr 
            340                 345                 350         


Asn Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly 
        355                 360                 365             


Arg Lys Gly Val Ala Ile Asn Phe Val Thr Glu Glu Asp Lys Arg Ile 
    370                 375                 380                 


Leu Arg Asp Ile Glu Thr Phe Tyr Asn Thr Thr Val Glu Glu Met Pro 
385                 390                 395                 400 


Met Asn Val Ala Asp Leu Ile 
                405         


<210>  3474
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4A3__Homo_sapiens__NP_055555

<400>  3474

Met Ala Thr Thr Ala Thr Met Ala Thr Ser Gly Ser Ala Arg Lys Arg 
1               5                   10                  15      


Leu Leu Lys Glu Glu Asp Met Thr Lys Val Glu Phe Glu Thr Ser Glu 
            20                  25                  30          


Glu Val Asp Val Thr Pro Thr Phe Asp Thr Met Gly Leu Arg Glu Asp 
        35                  40                  45              


Leu Leu Arg Gly Ile Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile 
    50                  55                  60                  


Gln Gln Arg Ala Ile Lys Gln Ile Ile Lys Gly Arg Asp Val Ile Ala 
65                  70                  75                  80  


Gln Ser Gln Ser Gly Thr Gly Lys Thr Ala Thr Phe Ser Ile Ser Val 
                85                  90                  95      


Leu Gln Cys Leu Asp Ile Gln Val Arg Glu Thr Gln Ala Leu Ile Leu 
            100                 105                 110         


Ala Pro Thr Arg Glu Leu Ala Val Gln Ile Gln Lys Gly Leu Leu Ala 
        115                 120                 125             


Leu Gly Asp Tyr Met Asn Val Gln Cys His Ala Cys Ile Gly Gly Thr 
    130                 135                 140                 


Asn Val Gly Glu Asp Ile Arg Lys Leu Asp Tyr Gly Gln His Val Val 
145                 150                 155                 160 


Ala Gly Thr Pro Gly Arg Val Phe Asp Met Ile Arg Arg Arg Ser Leu 
                165                 170                 175     


Arg Thr Arg Ala Ile Lys Met Leu Val Leu Asp Glu Ala Asp Glu Met 
            180                 185                 190         


Leu Asn Lys Gly Phe Lys Glu Gln Ile Tyr Asp Val Tyr Arg Tyr Leu 
        195                 200                 205             


Pro Pro Ala Thr Gln Val Val Leu Ile Ser Ala Thr Leu Pro His Glu 
    210                 215                 220                 


Ile Leu Glu Met Thr Asn Lys Phe Met Thr Asp Pro Ile Arg Ile Leu 
225                 230                 235                 240 


Val Lys Arg Asp Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Phe Val 
                245                 250                 255     


Ala Val Glu Arg Glu Glu Trp Lys Phe Asp Thr Leu Cys Asp Leu Tyr 
            260                 265                 270         


Asp Thr Leu Thr Ile Thr Gln Ala Val Ile Phe Cys Asn Thr Lys Arg 
        275                 280                 285             


Lys Val Asp Trp Leu Thr Glu Lys Met Arg Glu Ala Asn Phe Thr Val 
    290                 295                 300                 


Ser Ser Met His Gly Asp Met Pro Gln Lys Glu Arg Glu Ser Ile Met 
305                 310                 315                 320 


Lys Glu Phe Arg Ser Gly Ala Ser Arg Val Leu Ile Ser Thr Asp Val 
                325                 330                 335     


Trp Ala Arg Gly Leu Asp Val Pro Gln Val Ser Leu Ile Ile Asn Tyr 
            340                 345                 350         


Asp Leu Pro Asn Asn Arg Glu Leu Tyr Ile His Arg Ile Gly Arg Ser 
        355                 360                 365             


Gly Arg Tyr Gly Arg Lys Gly Val Ala Ile Asn Phe Val Lys Asn Asp 
    370                 375                 380                 


Asp Ile Arg Ile Leu Arg Asp Ile Glu Gln Tyr Tyr Ser Thr Gln Ile 
385                 390                 395                 400 


Asp Glu Met Pro Met Asn Val Ala Asp Leu Ile 
                405                 410     


<210>  3475
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4B__Homo_sapiens__NP_001408

<400>  3475

Met Ala Ala Ser Ala Lys Lys Lys Asn Lys Lys Gly Lys Thr Ile Ser 
1               5                   10                  15      


Leu Thr Asp Phe Leu Ala Glu Asp Gly Gly Thr Gly Gly Gly Ser Thr 
            20                  25                  30          


Tyr Val Ser Lys Pro Val Ser Trp Ala Asp Glu Thr Asp Asp Leu Glu 
        35                  40                  45              


Gly Asp Val Ser Thr Thr Trp His Ser Asn Asp Asp Asp Val Tyr Arg 
    50                  55                  60                  


Ala Pro Pro Ile Asp Arg Ser Ile Leu Pro Thr Ala Pro Arg Ala Ala 
65                  70                  75                  80  


Arg Glu Pro Asn Ile Asp Arg Ser Arg Leu Pro Lys Ser Pro Pro Tyr 
                85                  90                  95      


Thr Ala Phe Leu Gly Asn Leu Pro Tyr Asp Val Thr Glu Glu Ser Ile 
            100                 105                 110         


Lys Glu Phe Phe Arg Gly Leu Asn Ile Ser Ala Val Arg Leu Pro Arg 
        115                 120                 125             


Glu Pro Ser Asn Pro Glu Arg Leu Lys Gly Phe Gly Tyr Ala Glu Phe 
    130                 135                 140                 


Glu Asp Leu Asp Ser Leu Leu Ser Ala Leu Ser Leu Asn Glu Glu Ser 
145                 150                 155                 160 


Leu Gly Asn Arg Arg Ile Arg Val Asp Val Ala Asp Gln Ala Gln Asp 
                165                 170                 175     


Lys Asp Arg Asp Asp Arg Ser Phe Gly Arg Asp Arg Asn Arg Asp Ser 
            180                 185                 190         


Asp Lys Thr Asp Thr Asp Trp Arg Ala Arg Pro Ala Thr Asp Ser Phe 
        195                 200                 205             


Asp Asp Tyr Pro Pro Arg Arg Gly Asp Asp Ser Phe Gly Asp Lys Tyr 
    210                 215                 220                 


Arg Asp Arg Tyr Asp Ser Asp Arg Tyr Arg Asp Gly Tyr Arg Asp Gly 
225                 230                 235                 240 


Tyr Arg Asp Gly Pro Arg Arg Asp Met Asp Arg Tyr Gly Gly Arg Asp 
                245                 250                 255     


Arg Tyr Asp Asp Arg Gly Ser Arg Asp Tyr Asp Arg Gly Tyr Asp Ser 
            260                 265                 270         


Arg Ile Gly Ser Gly Arg Arg Ala Phe Gly Ser Gly Tyr Arg Arg Asp 
        275                 280                 285             


Asp Asp Tyr Arg Gly Gly Gly Asp Arg Tyr Glu Asp Arg Tyr Asp Arg 
    290                 295                 300                 


Arg Asp Asp Arg Ser Trp Ser Ser Arg Asp Asp Tyr Ser Arg Asp Asp 
305                 310                 315                 320 


Tyr Arg Arg Asp Asp Arg Gly Pro Pro Gln Arg Pro Lys Leu Asn Leu 
                325                 330                 335     


Lys Pro Arg Ser Thr Pro Lys Glu Asp Asp Ser Ser Ala Ser Thr Ser 
            340                 345                 350         


Gln Ser Thr Arg Ala Ala Ser Ile Phe Gly Gly Ala Lys Pro Val Asp 
        355                 360                 365             


Thr Ala Ala Arg Glu Arg Glu Val Glu Glu Arg Leu Gln Lys Glu Gln 
    370                 375                 380                 


Glu Lys Leu Gln Arg Gln Leu Asp Glu Pro Lys Leu Glu Arg Arg Pro 
385                 390                 395                 400 


Arg Glu Arg His Pro Ser Trp Arg Ser Glu Glu Thr Gln Glu Arg Glu 
                405                 410                 415     


Arg Ser Arg Thr Gly Ser Glu Ser Ser Gln Thr Gly Thr Ser Thr Thr 
            420                 425                 430         


Ser Ser Arg Asn Ala Arg Arg Arg Glu Ser Glu Lys Ser Leu Glu Asn 
        435                 440                 445             


Glu Thr Leu Asn Lys Glu Glu Asp Cys His Ser Pro Thr Ser Lys Pro 
    450                 455                 460                 


Pro Lys Pro Asp Gln Pro Leu Lys Val Met Pro Ala Pro Pro Pro Lys 
465                 470                 475                 480 


Glu Asn Ala Trp Val Lys Arg Ser Ser Asn Pro Pro Ala Arg Ser Gln 
                485                 490                 495     


Ser Ser Asp Thr Glu Gln Gln Ser Pro Thr Ser Gly Gly Gly Lys Val 
            500                 505                 510         


Ala Pro Ala Gln Pro Ser Glu Glu Gly Pro Gly Arg Lys Asp Glu Asn 
        515                 520                 525             


Lys Val Asp Gly Met Asn Ala Pro Lys Gly Gln Thr Gly Asn Ser Ser 
    530                 535                 540                 


Arg Gly Pro Gly Asp Gly Gly Asn Arg Asp His Trp Lys Glu Ser Asp 
545                 550                 555                 560 


Arg Lys Asp Gly Lys Lys Asp Gln Asp Ser Arg Ser Ala Pro Glu Pro 
                565                 570                 575     


Lys Lys Pro Glu Glu Asn Pro Ala Ser Lys Phe Ser Ser Ala Ser Lys 
            580                 585                 590         


Tyr Ala Ala Leu Ser Val Asp Gly Glu Asp Glu Asn Glu Gly Glu Asp 
        595                 600                 605             


Tyr Ala Glu 
    610     


<210>  3476
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4E2__Homo_sapiens__NP_001263265

<400>  3476

Met Asn Asn Lys Phe Asp Ala Leu Lys Asp Asp Asp Ser Gly Asp His 
1               5                   10                  15      


Asp Gln Asn Glu Glu Asn Ser Thr Gln Lys Asp Gly Glu Lys Glu Lys 
            20                  25                  30          


Thr Glu Arg Asp Lys Asn Gln Ser Ser Ser Lys Arg Lys Ala Val Val 
        35                  40                  45              


Pro Gly Pro Ala Glu His Pro Leu Gln Tyr Asn Tyr Thr Phe Trp Tyr 
    50                  55                  60                  


Ser Arg Arg Thr Pro Gly Arg Pro Thr Ser Ser Gln Ser Tyr Glu Gln 
65                  70                  75                  80  


Asn Ile Lys Gln Ile Gly Thr Phe Ala Ser Val Glu Gln Phe Trp Arg 
                85                  90                  95      


Phe Tyr Ser His Met Val Arg Pro Gly Asp Leu Thr Gly His Ser Asp 
            100                 105                 110         


Phe His Leu Phe Lys Glu Gly Ile Lys Pro Met Trp Glu Asp Asp Ala 
        115                 120                 125             


Asn Lys Asn Gly Gly Lys Trp Ile Ile Arg Leu Arg Lys Gly Leu Ala 
    130                 135                 140                 


Ser Arg Cys Trp Glu Asn Leu Ile Leu Ala Met Leu Gly Glu Gln Phe 
145                 150                 155                 160 


Met Val Gly Glu Glu Ile Cys Gly Ala Val Val Ser Val Arg Phe Gln 
                165                 170                 175     


Glu Asp Ile Ile Ser Ile Trp Asn Lys Thr Ala Ser Asp Gln Ala Thr 
            180                 185                 190         


Thr Ala Arg Ile Arg Asp Thr Leu Arg Arg Val Leu Asn Leu Pro Pro 
        195                 200                 205             


Asn Thr Ile Met Glu Tyr Lys Thr His Thr Asp Ser Ile Lys Asp Asn 
    210                 215                 220                 


Ser Ser Phe Arg Asn Thr Lys Ile Thr Leu 
225                 230                 


<210>  3477
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4E3__Homo_sapiens__NP_001128121

<400>  3477

Met Arg Gly Glu Arg Arg Pro Leu Trp Glu Glu Glu Ser Asn Ala Lys 
1               5                   10                  15      


Gly Gly Val Trp Lys Met Lys Val Pro Lys Asp Ser Thr Ser Thr Val 
            20                  25                  30          


Trp Lys Glu Leu Leu Leu Ala Thr Ile Gly Glu Gln Phe Thr Asp Cys 
        35                  40                  45              


Ala Ala Ala Asp Asp Glu Val Ile Gly Val Ser Val Ser Val Arg Asp 
    50                  55                  60                  


Arg Glu Asp Val Val Gln Val Trp Asn Val Asn Ala Ser Leu Val Gly 
65                  70                  75                  80  


Glu Ala Thr Val Leu Glu Lys Ile Tyr Glu Leu Leu Pro His Ile Thr 
                85                  90                  95      


Phe Lys Ala Val Phe Tyr Lys Pro His Glu Glu His His Ala Phe Glu 
            100                 105                 110         


Gly Gly Arg Gly Lys His 
        115             


<210>  3478
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4EBP1__Homo_sapiens__NP_004086

<400>  3478

Met Ser Gly Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
1               5                   10                  15      


Ala Thr Arg Arg Val Val Leu Gly Asp Gly Val Gln Leu Pro Pro Gly 
            20                  25                  30          


Asp Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
        35                  40                  45              


Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn 
    50                  55                  60                  


Ser Pro Val Thr Lys Thr Pro Pro Arg Asp Leu Pro Thr Ile Pro Gly 
65                  70                  75                  80  


Val Thr Ser Pro Ser Ser Asp Glu Pro Pro Met Glu Ala Ser Gln Ser 
                85                  90                  95      


His Leu Arg Asn Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser 
            100                 105                 110         


Gln Phe Glu Met Asp Ile 
        115             


<210>  3479
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4EBP2__Homo_sapiens__NP_004087

<400>  3479

Met Ser Ser Ser Ala Gly Ser Gly His Gln Pro Ser Gln Ser Arg Ala 
1               5                   10                  15      


Ile Pro Thr Arg Thr Val Ala Ile Ser Asp Ala Ala Gln Leu Pro His 
            20                  25                  30          


Asp Tyr Cys Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
        35                  40                  45              


Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Leu Asp Arg Arg Asn 
    50                  55                  60                  


Ser Pro Met Ala Gln Thr Pro Pro Cys His Leu Pro Asn Ile Pro Gly 
65                  70                  75                  80  


Val Thr Ser Pro Gly Thr Leu Ile Glu Asp Ser Lys Val Glu Val Asn 
                85                  90                  95      


Asn Leu Asn Asn Leu Asn Asn His Asp Arg Lys His Ala Val Gly Asp 
            100                 105                 110         


Asp Ala Gln Phe Glu Met Asp Ile 
        115                 120 


<210>  3480
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4EBP3__Homo_sapiens__NP_003723

<400>  3480

Met Ser Thr Ser Thr Ser Cys Pro Ile Pro Gly Gly Arg Asp Gln Leu 
1               5                   10                  15      


Pro Asp Cys Tyr Ser Thr Thr Pro Gly Gly Thr Leu Tyr Ala Thr Thr 
            20                  25                  30          


Pro Gly Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Leu Glu Cys 
        35                  40                  45              


Lys Asn Ser Pro Ile Ala Arg Thr Pro Pro Cys Cys Leu Pro Gln Ile 
    50                  55                  60                  


Pro Gly Val Thr Thr Pro Pro Thr Ala Pro Leu Ser Lys Leu Glu Glu 
65                  70                  75                  80  


Leu Lys Glu Gln Glu Thr Glu Glu Glu Ile Pro Asp Asp Ala Gln Phe 
                85                  90                  95      


Glu Met Asp Ile 
            100 


<210>  3481
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4E__Homo_sapiens__NP_001124150

<400>  3481

Met Leu Asp Leu Thr Ser Arg Gly Gln Val Gly Thr Ser Arg Arg Met 
1               5                   10                  15      


Ala Glu Ala Ala Cys Ser Ala His Phe Leu Glu Thr Thr Pro Thr Pro 
            20                  25                  30          


Asn Pro Pro Thr Thr Glu Glu Glu Lys Thr Glu Ser Asn Gln Glu Val 
        35                  40                  45              


Ala Asn Pro Glu His Tyr Ile Lys His Pro Leu Gln Asn Arg Trp Ala 
    50                  55                  60                  


Leu Trp Phe Phe Lys Asn Asp Lys Ser Lys Thr Trp Gln Ala Asn Leu 
65                  70                  75                  80  


Arg Leu Ile Ser Lys Phe Asp Thr Val Glu Asp Phe Trp Ala Leu Tyr 
                85                  90                  95      


Asn His Ile Gln Leu Ser Ser Asn Leu Met Pro Gly Cys Asp Tyr Ser 
            100                 105                 110         


Leu Phe Lys Asp Gly Ile Glu Pro Met Trp Glu Asp Glu Lys Asn Lys 
        115                 120                 125             


Arg Gly Gly Arg Trp Leu Ile Thr Leu Asn Lys Gln Gln Arg Arg Ser 
    130                 135                 140                 


Asp Leu Asp Arg Phe Trp Leu Glu Thr Leu Leu Cys Leu Ile Gly Glu 
145                 150                 155                 160 


Ser Phe Asp Asp Tyr Ser Asp Asp Val Cys Gly Ala Val Val Asn Val 
                165                 170                 175     


Arg Ala Lys Gly Asp Lys Ile Ala Ile Trp Thr Thr Glu Cys Glu Asn 
            180                 185                 190         


Arg Glu Ala Val Thr His Ile Gly Arg Val Tyr Lys Glu Arg Leu Gly 
        195                 200                 205             


Leu Pro Pro Lys Ile Val Ile Gly Tyr Gln Ser His Ala Asp Thr Ala 
    210                 215                 220                 


Thr Lys Ser Gly Ser Thr Thr Lys Asn Arg Phe Val Val 
225                 230                 235         


<210>  3482
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4ENIF1__Homo_sapiens__NP_001157974

<400>  3482

Met Asp Arg Arg Ser Met Gly Glu Thr Glu Ser Gly Asp Ala Phe Leu 
1               5                   10                  15      


Asp Leu Lys Lys Pro Pro Ala Ser Lys Cys Pro His Arg Tyr Thr Lys 
            20                  25                  30          


Glu Glu Leu Leu Asp Ile Lys Glu Leu Pro His Ser Lys Gln Arg Pro 
        35                  40                  45              


Ser Cys Leu Ser Glu Lys Tyr Asp Ser Asp Gly Val Trp Asp Pro Glu 
    50                  55                  60                  


Lys Trp His Ala Ser Leu Tyr Pro Ala Ser Gly Arg Ser Ser Pro Val 
65                  70                  75                  80  


Glu Ser Leu Lys Lys Glu Leu Asp Thr Asp Arg Pro Ser Leu Val Arg 
                85                  90                  95      


Arg Ile Val Gly Ile Val Glu Cys Asn Gly Gly Val Ala Glu Glu Asp 
            100                 105                 110         


Glu Val Glu Val Ile Leu Ala Gln Glu Pro Ala Ala Asp Gln Glu Val 
        115                 120                 125             


Pro Arg Asp Ala Val Leu Pro Glu Gln Ser Pro Gly Asp Phe Asp Phe 
    130                 135                 140                 


Asn Glu Phe Phe Asn Leu Asp Lys Val Pro Cys Leu Ala Ser Met Ile 
145                 150                 155                 160 


Glu Asp Val Leu Gly Glu Gly Ser Val Ser Ala Ser Arg Phe Ser Arg 
                165                 170                 175     


Trp Phe Ser Asn Pro Ser Arg Ser Gly Ser Arg Ser Ser Ser Leu Gly 
            180                 185                 190         


Ser Thr Pro His Glu Glu Leu Glu Arg Leu Ala Gly Leu Glu Gln Ala 
        195                 200                 205             


Ile Leu Ser Pro Gly Gln Asn Ser Gly Asn Tyr Phe Ala Pro Ile Pro 
    210                 215                 220                 


Leu Glu Asp His Ala Glu Asn Lys Val Asp Ile Leu Glu Met Leu Gln 
225                 230                 235                 240 


Lys Ala Lys Val Asp Leu Lys Pro Leu Leu Ser Ser Leu Ser Ala Asn 
                245                 250                 255     


Lys Glu Lys Leu Lys Glu Ser Ser His Ser Gly Val Val Leu Ser Val 
            260                 265                 270         


Glu Glu Val Glu Ala Gly Leu Lys Gly Leu Lys Val Asp Gln Gln Val 
        275                 280                 285             


Lys Asn Ser Thr Pro Phe Met Ala Glu His Leu Glu Glu Thr Leu Ser 
    290                 295                 300                 


Ala Val Thr Asn Asn Arg Gln Leu Lys Lys Asp Gly Asp Met Thr Ala 
305                 310                 315                 320 


Phe Asn Lys Leu Val Ser Thr Met Lys Arg Asn Leu Glu Ser His Leu 
                325                 330                 335     


Met Ser Pro Ala Glu Ile Pro Gly Gln Pro Val Pro Lys Asn Ile Leu 
            340                 345                 350         


Gln Glu Leu Leu Gly Gln Pro Val Gln Arg Pro Ala Ser Ser Asn Leu 
        355                 360                 365             


Leu Ser Gly Leu Met Gly Ser Leu Glu Pro Thr Thr Ser Leu Leu Gly 
    370                 375                 380                 


Gln Arg Ala Pro Ser Pro Pro Leu Ser Gln Val Phe Gln Thr Arg Ala 
385                 390                 395                 400 


Ala Ser Ala Asp Tyr Leu Arg Pro Arg Ile Pro Ser Pro Ile Gly Phe 
                405                 410                 415     


Thr Pro Gly Pro Gln Gln Leu Leu Gly Asp Pro Phe Gln Gly Met Arg 
            420                 425                 430         


Lys Pro Met Ser Pro Ile Thr Ala Gln Gln Met Ser Gln Leu Glu Leu 
        435                 440                 445             


Gln Gln Ala Ala Leu Glu Gly Leu Ala Leu Pro His Asp Leu Ala Val 
    450                 455                 460                 


Gln Ala Ala Asn Phe Tyr Gln Pro Gly Phe Gly Lys Pro Gln Val Asp 
465                 470                 475                 480 


Arg Thr Arg Asp Gly Phe Arg Asn Arg Gln Gln Arg Val Thr Lys Ser 
                485                 490                 495     


Pro Ala Pro Val His Arg Gly Asn Ser Ser Ser Pro Ala Pro Ala Ala 
            500                 505                 510         


Ser Ile Thr Ser Met Leu Ser Pro Ser Phe Thr Pro Thr Ser Val Ile 
        515                 520                 525             


Arg Lys Met Tyr Glu Ser Lys Glu Lys Ser Lys Glu Glu Pro Ala Ser 
    530                 535                 540                 


Gly Lys Ala Ala Leu Gly Asp Ser Lys Glu Asp Thr Gln Lys Ala Ser 
545                 550                 555                 560 


Glu Glu Asn Leu Leu Ser Ser Ser Ser Val Pro Ser Ala Asp Arg Asp 
                565                 570                 575     


Ser Ser Pro Thr Thr Asn Ser Lys Leu Ser Ala Leu Gln Arg Ser Ser 
            580                 585                 590         


Cys Ser Thr Pro Leu Ser Gln Ala Asn Arg Tyr Thr Lys Glu Gln Asp 
        595                 600                 605             


Tyr Arg Pro Lys Ala Thr Gly Arg Lys Thr Pro Thr Leu Ala Ser Pro 
    610                 615                 620                 


Val Pro Thr Thr Pro Phe Leu Arg Pro Val His Gln Val Pro Leu Val 
625                 630                 635                 640 


Pro His Val Pro Met Val Arg Pro Ala His Gln Leu His Pro Gly Leu 
                645                 650                 655     


Val Gln Arg Met Leu Ala Gln Gly Val His Pro Gln His Leu Pro Ser 
            660                 665                 670         


Leu Leu Gln Thr Gly Val Leu Pro Pro Gly Met Asp Leu Ser His Leu 
        675                 680                 685             


Gln Gly Ile Ser Gly Pro Ile Leu Gly Gln Pro Phe Tyr Pro Leu Pro 
    690                 695                 700                 


Ala Ala Ser His Pro Leu Leu Asn Pro Arg Pro Gly Thr Pro Leu His 
705                 710                 715                 720 


Leu Ala Met Val Gln Gln Gln Leu Gln Arg Ser Val Leu His Pro Pro 
                725                 730                 735     


Gly Ser Gly Ser His Ala Ala Ala Val Ser Val Gln Thr Thr Pro Gln 
            740                 745                 750         


Asn Val Pro Ser Arg Ser Gly Leu Pro His Met His Ser Gln Leu Glu 
        755                 760                 765             


His Arg Pro Ser Gln Arg Ser Ser Ser Pro Val Gly Leu Ala Lys Trp 
    770                 775                 780                 


Phe Gly Ser Asp Val Leu Gln Gln Pro Leu Pro Ser Met Pro Ala Lys 
785                 790                 795                 800 


Val Ile Ser Val Asp Glu Leu Glu Tyr Arg Gln 
                805                 810     


<210>  3483
<211>  1606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4G1__Homo_sapiens__NP_001181876

<400>  3483

Met Asn Lys Ala Pro Gln Ser Thr Gly Pro Pro Pro Ala Pro Ser Pro 
1               5                   10                  15      


Gly Leu Pro Gln Pro Ala Phe Pro Pro Gly Gln Thr Ala Pro Val Val 
            20                  25                  30          


Phe Ser Thr Pro Gln Ala Thr Gln Met Asn Thr Pro Ser Gln Pro Arg 
        35                  40                  45              


Gln Gly Gly Phe Arg Ser Leu Gln His Phe Tyr Pro Ser Arg Ala Gln 
    50                  55                  60                  


Pro Pro Ser Ser Ala Ala Ser Arg Val Gln Ser Ala Ala Pro Ala Arg 
65                  70                  75                  80  


Pro Gly Pro Ala Ala His Val Tyr Pro Ala Gly Ser Gln Val Met Met 
                85                  90                  95      


Ile Pro Ser Gln Ile Ser Tyr Pro Ala Ser Gln Gly Ala Tyr Tyr Ile 
            100                 105                 110         


Pro Gly Gln Gly Arg Ser Thr Tyr Val Val Pro Thr Gln Gln Tyr Pro 
        115                 120                 125             


Val Gln Pro Gly Ala Pro Gly Phe Tyr Pro Gly Ala Ser Pro Thr Glu 
    130                 135                 140                 


Phe Gly Thr Tyr Ala Gly Ala Tyr Tyr Pro Ala Gln Gly Val Gln Gln 
145                 150                 155                 160 


Phe Pro Thr Gly Val Ala Pro Ala Pro Val Leu Met Asn Gln Pro Pro 
                165                 170                 175     


Gln Ile Ala Pro Lys Arg Glu Arg Lys Thr Ile Arg Ile Arg Asp Pro 
            180                 185                 190         


Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser Gly Ala Arg 
        195                 200                 205             


Thr Ala Ser Thr Pro Thr Pro Pro Gln Thr Gly Gly Gly Leu Glu Pro 
    210                 215                 220                 


Gln Ala Asn Gly Glu Thr Pro Gln Val Ala Val Ile Val Arg Pro Asp 
225                 230                 235                 240 


Asp Arg Ser Gln Gly Ala Ile Ile Ala Asp Arg Pro Gly Leu Pro Gly 
                245                 250                 255     


Pro Glu His Ser Pro Ser Glu Ser Gln Pro Ser Ser Pro Ser Pro Thr 
            260                 265                 270         


Pro Ser Pro Ser Pro Val Leu Glu Pro Gly Ser Glu Pro Asn Leu Ala 
        275                 280                 285             


Val Leu Ser Ile Pro Gly Asp Thr Met Thr Thr Ile Gln Met Ser Val 
    290                 295                 300                 


Glu Glu Ser Thr Pro Ile Ser Arg Glu Thr Gly Glu Pro Tyr Arg Leu 
305                 310                 315                 320 


Ser Pro Glu Pro Thr Pro Leu Ala Glu Pro Ile Leu Glu Val Glu Val 
                325                 330                 335     


Thr Leu Ser Lys Pro Val Pro Glu Ser Glu Phe Ser Ser Ser Pro Leu 
            340                 345                 350         


Gln Ala Pro Thr Pro Leu Ala Ser His Thr Val Glu Ile His Glu Pro 
        355                 360                 365             


Asn Gly Met Val Pro Ser Glu Asp Leu Glu Pro Glu Val Glu Ser Ser 
    370                 375                 380                 


Pro Glu Leu Ala Pro Pro Pro Ala Cys Pro Ser Glu Ser Pro Val Pro 
385                 390                 395                 400 


Ile Ala Pro Thr Ala Gln Pro Glu Glu Leu Leu Asn Gly Ala Pro Ser 
                405                 410                 415     


Pro Pro Ala Val Asp Leu Ser Pro Val Ser Glu Pro Glu Glu Gln Ala 
            420                 425                 430         


Lys Glu Val Thr Ala Ser Met Ala Pro Pro Thr Ile Pro Ser Ala Thr 
        435                 440                 445             


Pro Ala Thr Ala Pro Ser Ala Thr Ser Pro Ala Gln Glu Glu Glu Met 
    450                 455                 460                 


Glu Glu Glu Glu Glu Glu Glu Glu Gly Glu Ala Gly Glu Ala Gly Glu 
465                 470                 475                 480 


Ala Glu Ser Glu Lys Gly Gly Glu Glu Leu Leu Pro Pro Glu Ser Thr 
                485                 490                 495     


Pro Ile Pro Ala Asn Leu Ser Gln Asn Leu Glu Ala Ala Ala Ala Thr 
            500                 505                 510         


Gln Val Ala Val Ser Val Pro Lys Arg Arg Arg Lys Ile Lys Glu Leu 
        515                 520                 525             


Asn Lys Lys Glu Ala Val Gly Asp Leu Leu Asp Ala Phe Lys Glu Ala 
    530                 535                 540                 


Asn Pro Ala Val Pro Glu Val Glu Asn Gln Pro Pro Ala Gly Ser Asn 
545                 550                 555                 560 


Pro Gly Pro Glu Ser Glu Gly Ser Gly Val Pro Pro Arg Pro Glu Glu 
                565                 570                 575     


Ala Asp Glu Thr Trp Asp Ser Lys Glu Asp Lys Ile His Asn Ala Glu 
            580                 585                 590         


Asn Ile Gln Pro Gly Glu Gln Lys Tyr Glu Tyr Lys Ser Asp Gln Trp 
        595                 600                 605             


Lys Pro Leu Asn Leu Glu Glu Lys Lys Arg Tyr Asp Arg Glu Phe Leu 
    610                 615                 620                 


Leu Gly Phe Gln Phe Ile Phe Ala Ser Met Gln Lys Pro Glu Gly Leu 
625                 630                 635                 640 


Pro His Ile Ser Asp Val Val Leu Asp Lys Ala Asn Lys Thr Pro Leu 
                645                 650                 655     


Arg Pro Leu Asp Pro Thr Arg Leu Gln Gly Ile Asn Cys Gly Pro Asp 
            660                 665                 670         


Phe Thr Pro Ser Phe Ala Asn Leu Gly Arg Thr Thr Leu Ser Thr Arg 
        675                 680                 685             


Gly Pro Pro Arg Gly Gly Pro Gly Gly Glu Leu Pro Arg Gly Pro Ala 
    690                 695                 700                 


Gly Leu Gly Pro Arg Arg Ser Gln Gln Gly Pro Arg Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Ile Ile Ala Thr Val Leu Met Thr Glu Asp Ile Lys Leu Asn Lys 
                725                 730                 735     


Ala Glu Lys Ala Trp Lys Pro Ser Ser Lys Arg Thr Ala Ala Asp Lys 
            740                 745                 750         


Asp Arg Gly Glu Glu Asp Ala Asp Gly Ser Lys Thr Gln Asp Leu Phe 
        755                 760                 765             


Arg Arg Val Arg Ser Ile Leu Asn Lys Leu Thr Pro Gln Met Phe Gln 
    770                 775                 780                 


Gln Leu Met Lys Gln Val Thr Gln Leu Ala Ile Asp Thr Glu Glu Arg 
785                 790                 795                 800 


Leu Lys Gly Val Ile Asp Leu Ile Phe Glu Lys Ala Ile Ser Glu Pro 
                805                 810                 815     


Asn Phe Ser Val Ala Tyr Ala Asn Met Cys Arg Cys Leu Met Ala Leu 
            820                 825                 830         


Lys Val Pro Thr Thr Glu Lys Pro Thr Val Thr Val Asn Phe Arg Lys 
        835                 840                 845             


Leu Leu Leu Asn Arg Cys Gln Lys Glu Phe Glu Lys Asp Lys Asp Asp 
    850                 855                 860                 


Asp Glu Val Phe Glu Lys Lys Gln Lys Glu Met Asp Glu Ala Ala Thr 
865                 870                 875                 880 


Ala Glu Glu Arg Gly Arg Leu Lys Glu Glu Leu Glu Glu Ala Arg Asp 
                885                 890                 895     


Ile Ala Arg Arg Arg Ser Leu Gly Asn Ile Lys Phe Ile Gly Glu Leu 
            900                 905                 910         


Phe Lys Leu Lys Met Leu Thr Glu Ala Ile Met His Asp Cys Val Val 
        915                 920                 925             


Lys Leu Leu Lys Asn His Asp Glu Glu Ser Leu Glu Cys Leu Cys Arg 
    930                 935                 940                 


Leu Leu Thr Thr Ile Gly Lys Asp Leu Asp Phe Glu Lys Ala Lys Pro 
945                 950                 955                 960 


Arg Met Asp Gln Tyr Phe Asn Gln Met Glu Lys Ile Ile Lys Glu Lys 
                965                 970                 975     


Lys Thr Ser Ser Arg Ile Arg Phe Met Leu Gln Asp Val Leu Asp Leu 
            980                 985                 990         


Arg Gly Ser Asn Trp Val Pro Arg  Arg Gly Asp Gln Gly  Pro Lys Thr 
        995                 1000                 1005             


Ile Asp  Gln Ile His Lys Glu  Ala Glu Met Glu Glu  His Arg Glu 
    1010                 1015                 1020             


His Ile  Lys Val Gln Gln Leu  Met Ala Lys Gly Ser  Asp Lys Arg 
    1025                 1030                 1035             


Arg Gly  Gly Pro Pro Gly Pro  Pro Ile Ser Arg Gly  Leu Pro Leu 
    1040                 1045                 1050             


Val Asp  Asp Gly Gly Trp Asn  Thr Val Pro Ile Ser  Lys Gly Ser 
    1055                 1060                 1065             


Arg Pro  Ile Asp Thr Ser Arg  Leu Thr Lys Ile Thr  Lys Pro Gly 
    1070                 1075                 1080             


Ser Ile  Asp Ser Asn Asn Gln  Leu Phe Ala Pro Gly  Gly Arg Leu 
    1085                 1090                 1095             


Ser Trp  Gly Lys Gly Ser Ser  Gly Gly Ser Gly Ala  Lys Pro Ser 
    1100                 1105                 1110             


Asp Ala  Ala Ser Glu Ala Ala  Arg Pro Ala Thr Ser  Thr Leu Asn 
    1115                 1120                 1125             


Arg Phe  Ser Ala Leu Gln Gln  Ala Val Pro Thr Glu  Ser Thr Asp 
    1130                 1135                 1140             


Asn Arg  Arg Val Val Gln Arg  Ser Ser Leu Ser Arg  Glu Arg Gly 
    1145                 1150                 1155             


Glu Lys  Ala Gly Asp Arg Gly  Asp Arg Leu Glu Arg  Ser Glu Arg 
    1160                 1165                 1170             


Gly Gly  Asp Arg Gly Asp Arg  Leu Asp Arg Ala Arg  Thr Pro Ala 
    1175                 1180                 1185             


Thr Lys  Arg Ser Phe Ser Lys  Glu Val Glu Glu Arg  Ser Arg Glu 
    1190                 1195                 1200             


Arg Pro  Ser Gln Pro Glu Gly  Leu Arg Lys Ala Ala  Ser Leu Thr 
    1205                 1210                 1215             


Glu Asp  Arg Asp Arg Gly Arg  Asp Ala Val Lys Arg  Glu Ala Ala 
    1220                 1225                 1230             


Leu Pro  Pro Val Ser Pro Leu  Lys Ala Ala Leu Ser  Glu Glu Glu 
    1235                 1240                 1245             


Leu Glu  Lys Lys Ser Lys Ala  Ile Ile Glu Glu Tyr  Leu His Leu 
    1250                 1255                 1260             


Asn Asp  Met Lys Glu Ala Val  Gln Cys Val Gln Glu  Leu Ala Ser 
    1265                 1270                 1275             


Pro Ser  Leu Leu Phe Ile Phe  Val Arg His Gly Val  Glu Ser Thr 
    1280                 1285                 1290             


Leu Glu  Arg Ser Ala Ile Ala  Arg Glu His Met Gly  Gln Leu Leu 
    1295                 1300                 1305             


His Gln  Leu Leu Cys Ala Gly  His Leu Ser Thr Ala  Gln Tyr Tyr 
    1310                 1315                 1320             


Gln Gly  Leu Tyr Glu Ile Leu  Glu Leu Ala Glu Asp  Met Glu Ile 
    1325                 1330                 1335             


Asp Ile  Pro His Val Trp Leu  Tyr Leu Ala Glu Leu  Val Thr Pro 
    1340                 1345                 1350             


Ile Leu  Gln Glu Gly Gly Val  Pro Met Gly Glu Leu  Phe Arg Glu 
    1355                 1360                 1365             


Ile Thr  Lys Pro Leu Arg Pro  Leu Gly Lys Ala Ala  Ser Leu Leu 
    1370                 1375                 1380             


Leu Glu  Ile Leu Gly Leu Leu  Cys Lys Ser Met Gly  Pro Lys Lys 
    1385                 1390                 1395             


Val Gly  Thr Leu Trp Arg Glu  Ala Gly Leu Ser Trp  Lys Glu Phe 
    1400                 1405                 1410             


Leu Pro  Glu Gly Gln Asp Ile  Gly Ala Phe Val Ala  Glu Gln Lys 
    1415                 1420                 1425             


Val Glu  Tyr Thr Leu Gly Glu  Glu Ser Glu Ala Pro  Gly Gln Arg 
    1430                 1435                 1440             


Ala Leu  Pro Ser Glu Glu Leu  Asn Arg Gln Leu Glu  Lys Leu Leu 
    1445                 1450                 1455             


Lys Glu  Gly Ser Ser Asn Gln  Arg Val Phe Asp Trp  Ile Glu Ala 
    1460                 1465                 1470             


Asn Leu  Ser Glu Gln Gln Ile  Val Ser Asn Thr Leu  Val Arg Ala 
    1475                 1480                 1485             


Leu Met  Thr Ala Val Cys Tyr  Ser Ala Ile Ile Phe  Glu Thr Pro 
    1490                 1495                 1500             


Leu Arg  Val Asp Val Ala Val  Leu Lys Ala Arg Ala  Lys Leu Leu 
    1505                 1510                 1515             


Gln Lys  Tyr Leu Cys Asp Glu  Gln Lys Glu Leu Gln  Ala Leu Tyr 
    1520                 1525                 1530             


Ala Leu  Gln Ala Leu Val Val  Thr Leu Glu Gln Pro  Pro Asn Leu 
    1535                 1540                 1545             


Leu Arg  Met Phe Phe Asp Ala  Leu Tyr Asp Glu Asp  Val Val Lys 
    1550                 1555                 1560             


Glu Asp  Ala Phe Tyr Ser Trp  Glu Ser Ser Lys Asp  Pro Ala Glu 
    1565                 1570                 1575             


Gln Gln  Gly Lys Gly Val Ala  Leu Lys Ser Val Thr  Ala Phe Phe 
    1580                 1585                 1590             


Lys Trp  Leu Arg Glu Ala Glu  Glu Glu Ser Asp His  Asn 
    1595                 1600                 1605     


<210>  3484
<211>  869
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4G2__Homo_sapiens__NP_001036024

<400>  3484

Met Glu Ser Ala Ile Ala Glu Gly Gly Ala Ser Arg Phe Ser Ala Ser 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Arg Gly Ala Pro Gln His Tyr Pro Lys Thr 
            20                  25                  30          


Ala Gly Asn Ser Glu Phe Leu Gly Lys Thr Pro Gly Gln Asn Ala Gln 
        35                  40                  45              


Lys Trp Ile Pro Ala Arg Ser Thr Arg Arg Asp Asp Asn Ser Ala Ala 
    50                  55                  60                  


Asn Asn Ser Ala Asn Glu Lys Glu Arg His Asp Ala Ile Phe Arg Lys 
65                  70                  75                  80  


Val Arg Gly Ile Leu Asn Lys Leu Thr Pro Glu Lys Phe Asp Lys Leu 
                85                  90                  95      


Cys Leu Glu Leu Leu Asn Val Gly Val Glu Ser Lys Leu Ile Leu Lys 
            100                 105                 110         


Gly Val Ile Leu Leu Ile Val Asp Lys Ala Leu Glu Glu Pro Lys Tyr 
        115                 120                 125             


Ser Ser Leu Tyr Ala Gln Leu Cys Leu Arg Leu Ala Glu Asp Ala Pro 
    130                 135                 140                 


Asn Phe Asp Gly Pro Ala Ala Glu Gly Gln Pro Gly Gln Lys Gln Ser 
145                 150                 155                 160 


Thr Thr Phe Arg Arg Leu Leu Ile Ser Lys Leu Gln Asp Glu Phe Glu 
                165                 170                 175     


Asn Arg Thr Arg Asn Val Asp Val Tyr Asp Lys Arg Glu Asn Pro Leu 
            180                 185                 190         


Leu Pro Glu Glu Glu Glu Gln Arg Ala Ile Ala Lys Ile Lys Met Leu 
        195                 200                 205             


Gly Asn Ile Lys Phe Ile Gly Glu Leu Gly Lys Leu Asp Leu Ile His 
    210                 215                 220                 


Glu Ser Ile Leu His Lys Cys Ile Lys Thr Leu Leu Glu Lys Lys Lys 
225                 230                 235                 240 


Arg Val Gln Leu Lys Asp Met Gly Glu Asp Leu Glu Cys Leu Cys Gln 
                245                 250                 255     


Ile Met Arg Thr Val Gly Pro Arg Leu Asp His Glu Arg Ala Lys Ser 
            260                 265                 270         


Leu Met Asp Gln Tyr Phe Ala Arg Met Cys Ser Leu Met Leu Ser Lys 
        275                 280                 285             


Glu Leu Pro Ala Arg Ile Arg Phe Leu Leu Gln Asp Thr Val Glu Leu 
    290                 295                 300                 


Arg Glu His His Trp Val Pro Arg Lys Ala Phe Leu Asp Asn Gly Pro 
305                 310                 315                 320 


Lys Thr Ile Asn Gln Ile Arg Gln Asp Ala Val Lys Asp Leu Gly Val 
                325                 330                 335     


Phe Ile Pro Ala Pro Met Ala Gln Gly Met Arg Ser Asp Phe Phe Leu 
            340                 345                 350         


Glu Gly Pro Phe Met Pro Pro Arg Met Lys Met Asp Arg Asp Pro Leu 
        355                 360                 365             


Gly Gly Leu Ala Asp Met Phe Gly Gln Met Pro Gly Ser Gly Ile Gly 
    370                 375                 380                 


Thr Gly Pro Gly Val Ile Gln Asp Arg Phe Ser Pro Thr Met Gly Arg 
385                 390                 395                 400 


His Arg Ser Asn Gln Leu Phe Asn Gly His Gly Gly His Ile Met Pro 
                405                 410                 415     


Pro Thr Gln Ser Gln Phe Gly Glu Met Gly Gly Lys Phe Met Lys Ser 
            420                 425                 430         


Gln Ile Ser Leu Arg Pro Ala Gln Ser Phe Leu Met Asn Lys Asn Gln 
        435                 440                 445             


Val Pro Lys Leu Gln Pro Gln Ile Thr Met Ile Pro Pro Ser Ala Gln 
    450                 455                 460                 


Pro Pro Arg Thr Gln Thr Pro Pro Leu Gly Gln Thr Pro Gln Leu Gly 
465                 470                 475                 480 


Leu Lys Thr Asn Pro Pro Leu Ile Gln Glu Lys Pro Ala Lys Thr Ser 
                485                 490                 495     


Lys Lys Pro Pro Pro Ser Lys Glu Glu Leu Leu Lys Leu Thr Glu Thr 
            500                 505                 510         


Val Val Thr Glu Tyr Leu Asn Ser Gly Asn Ala Asn Glu Ala Val Asn 
        515                 520                 525             


Gly Val Arg Glu Met Arg Ala Pro Lys His Phe Leu Pro Glu Met Leu 
    530                 535                 540                 


Ser Lys Val Ile Ile Leu Ser Leu Asp Arg Ser Asp Glu Asp Lys Glu 
545                 550                 555                 560 


Lys Ala Ser Ser Leu Ile Ser Leu Leu Lys Gln Glu Gly Ile Ala Thr 
                565                 570                 575     


Ser Asp Asn Phe Met Gln Ala Phe Leu Asn Val Leu Asp Gln Cys Pro 
            580                 585                 590         


Lys Leu Glu Val Asp Ile Pro Leu Val Lys Ser Tyr Leu Ala Gln Phe 
        595                 600                 605             


Ala Ala Arg Ala Ile Ile Ser Glu Leu Val Ser Ile Ser Glu Leu Ala 
    610                 615                 620                 


Gln Pro Leu Glu Ser Gly Thr His Phe Pro Leu Phe Leu Leu Cys Leu 
625                 630                 635                 640 


Gln Gln Leu Ala Lys Leu Gln Asp Arg Glu Trp Leu Thr Glu Leu Phe 
                645                 650                 655     


Gln Gln Ser Lys Val Asn Met Gln Lys Met Leu Pro Glu Ile Asp Gln 
            660                 665                 670         


Asn Lys Asp Arg Met Leu Glu Ile Leu Glu Gly Lys Gly Leu Ser Phe 
        675                 680                 685             


Leu Phe Pro Leu Leu Lys Leu Glu Lys Glu Leu Leu Lys Gln Ile Lys 
    690                 695                 700                 


Leu Asp Pro Ser Pro Gln Thr Ile Tyr Lys Trp Ile Lys Asp Asn Ile 
705                 710                 715                 720 


Ser Pro Lys Leu His Val Asp Lys Gly Phe Val Asn Ile Leu Met Thr 
                725                 730                 735     


Ser Phe Leu Gln Tyr Ile Ser Ser Glu Val Asn Pro Pro Ser Asp Glu 
            740                 745                 750         


Thr Asp Ser Ser Ser Ala Pro Ser Lys Glu Gln Leu Glu Gln Glu Lys 
        755                 760                 765             


Gln Leu Leu Leu Ser Phe Lys Pro Val Met Gln Lys Phe Leu His Asp 
    770                 775                 780                 


His Val Asp Leu Gln Val Ser Ala Leu Tyr Ala Leu Gln Val His Cys 
785                 790                 795                 800 


Tyr Asn Ser Asn Phe Pro Lys Gly Met Leu Leu Arg Phe Phe Val His 
                805                 810                 815     


Phe Tyr Asp Met Glu Ile Ile Glu Glu Glu Ala Phe Leu Ala Trp Lys 
            820                 825                 830         


Glu Asp Ile Thr Gln Glu Phe Pro Gly Lys Gly Lys Ala Leu Phe Gln 
        835                 840                 845             


Val Asn Gln Trp Leu Thr Trp Leu Glu Thr Ala Glu Glu Glu Glu Ser 
    850                 855                 860                 


Glu Glu Glu Ala Asp 
865                 


<210>  3485
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF4H__Homo_sapiens__NP_071496

<400>  3485

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15      


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30          


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45              


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60                  


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80  


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95      


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110         


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125             


Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
    130                 135                 140                 


Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
145                 150                 155                 160 


Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                165                 170                 175     


Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
            180                 185                 190         


Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
        195                 200                 205             


Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
    210                 215                 220                 


Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
225                 230                 235                 240 


Glu Val Val Gln Lys Glu Gln Glu 
                245             


<210>  3486
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF5A2__Homo_sapiens__NP_065123

<400>  3486

Met Ala Asp Glu Ile Asp Phe Thr Thr Gly Asp Ala Gly Ala Ser Ser 
1               5                   10                  15      


Thr Tyr Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Tyr Gln Leu Ile Cys Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Thr Glu Thr Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Lys Leu Pro Glu Gly Glu Leu Gly Lys Glu Ile Glu Gly Lys Tyr Asn 
        115                 120                 125             


Ala Gly Glu Asp Val Gln Val Ser Val Met Cys Ala Met Ser Glu Glu 
    130                 135                 140                 


Tyr Ala Val Ala Ile Lys Pro Cys Lys 
145                 150             


<210>  3487
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF5A__Homo_sapiens__NP_001137232

<400>  3487

Met Cys Gly Thr Gly Gly Thr Asp Ser Lys Thr Arg Arg Pro Pro His 
1               5                   10                  15      


Arg Ala Ser Phe Leu Lys Arg Leu Glu Ser Lys Pro Leu Lys Met Ala 
            20                  25                  30          


Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala Thr Phe 
        35                  40                  45              


Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val Leu Lys 
    50                  55                  60                  


Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr Gly Lys 
65                  70                  75                  80  


His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe Thr Gly 
                85                  90                  95      


Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp Val Pro 
            100                 105                 110         


Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp Gly Tyr 
        115                 120                 125             


Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Arg Glu Asp Leu Arg Leu 
    130                 135                 140                 


Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp Cys Gly 
145                 150                 155                 160 


Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu Ala Ala 
                165                 170                 175     


Val Ala Ile Lys Ala Met Ala Lys 
            180                 


<210>  3488
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF5__Homo_sapiens__NP_892116

<400>  3488

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
1               5                   10                  15      


Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
            20                  25                  30          


Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
        35                  40                  45              


Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
    50                  55                  60                  


Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
65                  70                  75                  80  


Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                85                  90                  95      


Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
            100                 105                 110         


Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
        115                 120                 125             


Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
    130                 135                 140                 


Pro Pro Glu Asn Ser Asp Ser Gly Thr Gly Lys Lys Glu Lys Glu Lys 
145                 150                 155                 160 


Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Ser Ser 
                165                 170                 175     


Glu Thr Pro Pro Pro Pro Pro Pro Pro Asn Glu Ile Asn Pro Pro Pro 
            180                 185                 190         


His Thr Met Glu Glu Glu Glu Asp Asp Asp Trp Gly Glu Asp Thr Thr 
        195                 200                 205             


Glu Glu Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys 
    210                 215                 220                 


Val Leu Thr Leu Ser Asp Asp Leu Glu Arg Thr Ile Glu Glu Arg Val 
225                 230                 235                 240 


Asn Ile Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Val Ile 
                245                 250                 255     


Asp Ser Ser Asp Lys Glu Ile Val Ala Glu Ala Glu Arg Leu Asp Val 
            260                 265                 270         


Lys Ala Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asn Glu Lys 
        275                 280                 285             


Ile Arg Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys 
    290                 295                 300                 


His Asn Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys 
305                 310                 315                 320 


Val Val Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile 
                325                 330                 335     


Leu Lys Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile 
            340                 345                 350         


Ser Trp Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala 
        355                 360                 365             


Lys Glu Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu 
    370                 375                 380                 


Ala Glu Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn 
385                 390                 395                 400 


Ile Glu Val Val Tyr Ser Lys Ala Ala Ser Val Pro Lys Val Glu Thr 
                405                 410                 415     


Val Lys Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
            420                 425                 430     


<210>  3489
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIF6__Homo_sapiens__NP_001254739

<400>  3489

Met Ala Val Arg Ala Ser Phe Glu Asn Asn Cys Glu Ile Gly Cys Phe 
1               5                   10                  15      


Ala Lys Leu Thr Asn Thr Tyr Cys Leu Val Ala Ile Gly Gly Ser Glu 
            20                  25                  30          


Asn Phe Tyr Ser Val Phe Glu Gly Glu Leu Ser Asp Thr Ile Pro Val 
        35                  40                  45              


Val His Ala Ser Ile Ala Gly Cys Arg Ile Ile Gly Arg Met Cys Val 
    50                  55                  60                  


Gly Asn Arg His Gly Leu Leu Val Pro Asn Asn Thr Thr Asp Gln Glu 
65                  70                  75                  80  


Leu Gln His Ile Arg Asn Ser Leu Pro Asp Thr Val Gln Ile Arg Arg 
                85                  90                  95      


Val Glu Glu Arg Leu Ser Ala Leu Gly Asn Val Thr Thr Cys Asn Asp 
            100                 105                 110         


Tyr Val Ala Leu Val His Pro Asp Leu Asp Arg Glu Thr Glu Glu Ile 
        115                 120                 125             


Leu Ala Asp Val Leu Lys Val Glu Val Phe Arg Gln Thr Val Ala Asp 
    130                 135                 140                 


Gln Val Leu Val Gly Ser Tyr Cys Val Phe Ser Asn Gln Gly Gly Leu 
145                 150                 155                 160 


Val His Pro Lys Thr Ser Ile Glu Asp Gln Asp Glu Leu Ser Ser Leu 
                165                 170                 175     


Leu Gln Val Pro Leu Val Ala Gly Thr Val Asn Arg Gly Ser Glu Val 
            180                 185                 190         


Ile Ala Ala Gly Met Val Val Asn Asp Trp Cys Ala Phe Cys Gly Leu 
        195                 200                 205             


Asp Thr Thr Ser Thr Glu Leu Ser Val Val Glu Ser Val Phe Lys Leu 
    210                 215                 220                 


Asn Glu Ala Gln Pro Ser Thr Ile Ala Thr Ser Met Arg Asp Ser Leu 
225                 230                 235                 240 


Ile Asp Ser Leu Thr 
                245 


<210>  3490
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELAC1__Homo_sapiens__NP_061166

<400>  3490

Met Ser Met Asp Val Thr Phe Leu Gly Thr Gly Ala Ala Tyr Pro Ser 
1               5                   10                  15      


Pro Thr Arg Gly Ala Ser Ala Val Val Leu Arg Cys Glu Gly Glu Cys 
            20                  25                  30          


Trp Leu Phe Asp Cys Gly Glu Gly Thr Gln Thr Gln Leu Met Lys Ser 
        35                  40                  45              


Gln Leu Lys Ala Gly Arg Ile Thr Lys Ile Phe Ile Thr His Leu His 
    50                  55                  60                  


Gly Asp His Phe Phe Gly Leu Pro Gly Leu Leu Cys Thr Ile Ser Leu 
65                  70                  75                  80  


Gln Ser Gly Ser Met Val Ser Lys Gln Pro Ile Glu Ile Tyr Gly Pro 
                85                  90                  95      


Val Gly Leu Arg Asp Phe Ile Trp Arg Thr Met Glu Leu Ser His Thr 
            100                 105                 110         


Glu Leu Val Phe His Tyr Val Val His Glu Leu Val Pro Thr Ala Asp 
        115                 120                 125             


Gln Cys Pro Ala Glu Glu Leu Lys Glu Phe Ala His Val Asn Arg Ala 
    130                 135                 140                 


Asp Ser Pro Pro Lys Glu Glu Gln Gly Arg Thr Ile Leu Leu Asp Ser 
145                 150                 155                 160 


Glu Glu Asn Ser Tyr Leu Leu Phe Asp Asp Glu Gln Phe Val Val Lys 
                165                 170                 175     


Ala Phe Arg Leu Phe His Arg Ile Pro Ser Phe Gly Phe Ser Val Val 
            180                 185                 190         


Glu Lys Lys Arg Pro Gly Lys Leu Asn Ala Gln Lys Leu Lys Asp Leu 
        195                 200                 205             


Gly Val Pro Pro Gly Pro Ala Tyr Gly Lys Leu Lys Asn Gly Ile Ser 
    210                 215                 220                 


Val Val Leu Glu Asn Gly Val Thr Ile Ser Pro Gln Asp Val Leu Lys 
225                 230                 235                 240 


Lys Pro Ile Val Gly Arg Lys Ile Cys Ile Leu Gly Asp Cys Ser Gly 
                245                 250                 255     


Val Val Gly Asp Gly Gly Val Lys Leu Cys Phe Glu Ala Asp Leu Leu 
            260                 265                 270         


Ile His Glu Ala Thr Leu Asp Asp Ala Gln Met Asp Lys Ala Lys Glu 
        275                 280                 285             


His Gly His Ser Thr Pro Gln Met Ala Ala Thr Phe Ala Lys Leu Cys 
    290                 295                 300                 


Arg Ala Lys Arg Leu Val Leu Thr His Phe Ser Gln Arg Tyr Lys Pro 
305                 310                 315                 320 


Val Ala Leu Ala Arg Glu Gly Glu Thr Asp Gly Ile Ala Glu Leu Lys 
                325                 330                 335     


Lys Gln Ala Glu Ser Val Leu Asp Leu Gln Glu Val Thr Leu Ala Glu 
            340                 345                 350         


Asp Phe Met Val Ile Ser Ile Pro Ile Lys Lys 
        355                 360             


<210>  3491
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELAC2__Homo_sapiens__NP_001159434

<400>  3491

Met Trp Ala Leu Cys Ser Leu Leu Arg Ser Ala Ala Gly Arg Thr Met 
1               5                   10                  15      


Ser Gln Gly Arg Thr Ile Ser Gln Ala Pro Ala Arg Arg Glu Arg Pro 
            20                  25                  30          


Arg Lys Asp Pro Leu Arg His Leu Arg Thr Arg Glu Lys Arg Gly Pro 
        35                  40                  45              


Ser Gly Cys Ser Gly Gly Pro Asn Thr Val Tyr Leu Gln Val Val Ala 
    50                  55                  60                  


Ala Gly Ser Arg Asp Ser Gly Ala Ala Leu Tyr Val Phe Ser Glu Phe 
65                  70                  75                  80  


Asn Arg Tyr Leu Phe Asn Cys Gly Glu Gly Val Gln Arg Leu Met Gln 
                85                  90                  95      


Glu His Lys Leu Lys Val Ala Arg Leu Asp Asn Ile Phe Leu Thr Arg 
            100                 105                 110         


Met His Trp Ser Asn Val Gly Gly Leu Ser Gly Met Ile Leu Thr Leu 
        115                 120                 125             


Lys Glu Thr Gly Leu Pro Lys Cys Val Leu Ser Gly Pro Pro Gln Leu 
    130                 135                 140                 


Glu Lys Tyr Leu Glu Ala Ile Lys Ile Phe Ser Gly Pro Leu Lys Gly 
145                 150                 155                 160 


Ile Glu Leu Ala Val Arg Pro His Ser Ala Pro Glu Tyr Glu Asp Glu 
                165                 170                 175     


Thr Met Thr Val Tyr Gln Ile Pro Ile His Ser Val Ser Gln Arg Arg 
            180                 185                 190         


Gly Val Arg Asp Ser Ser Leu Val Val Ala Phe Ile Cys Lys Leu His 
        195                 200                 205             


Leu Lys Arg Gly Asn Phe Leu Val Leu Lys Ala Lys Glu Met Gly Leu 
    210                 215                 220                 


Pro Val Gly Thr Ala Ala Ile Ala Pro Ile Ile Ala Ala Val Lys Asp 
225                 230                 235                 240 


Gly Lys Ser Ile Thr His Glu Gly Arg Glu Ile Leu Ala Glu Glu Leu 
                245                 250                 255     


Cys Thr Pro Pro Asp Pro Gly Ala Ala Phe Val Val Val Glu Cys Pro 
            260                 265                 270         


Asp Glu Ser Phe Ile Gln Pro Ile Cys Glu Asn Ala Thr Phe Gln Arg 
        275                 280                 285             


Tyr Gln Gly Lys Ala Asp Ala Pro Val Ala Leu Val Val His Met Ala 
    290                 295                 300                 


Pro Ala Ser Val Leu Val Asp Ser Arg Tyr Gln Gln Trp Met Glu Arg 
305                 310                 315                 320 


Phe Gly Pro Asp Thr Gln His Leu Val Leu Asn Glu Asn Cys Ala Ser 
                325                 330                 335     


Val His Asn Leu Arg Ser His Lys Ile Gln Thr Gln Leu Asn Leu Ile 
            340                 345                 350         


His Pro Asp Ile Phe Pro Leu Leu Thr Ser Phe Arg Cys Lys Lys Glu 
        355                 360                 365             


Gly Pro Thr Leu Ser Val Pro Met Val Gln Gly Glu Cys Leu Leu Lys 
    370                 375                 380                 


Tyr Gln Leu Arg Pro Arg Arg Glu Trp Gln Arg Asp Ala Ile Ile Thr 
385                 390                 395                 400 


Cys Asn Pro Glu Glu Phe Ile Val Glu Ala Leu Gln Leu Pro Asn Phe 
                405                 410                 415     


Gln Gln Ser Val Gln Glu Tyr Arg Arg Ser Ala Gln Asp Gly Pro Ala 
            420                 425                 430         


Pro Ala Glu Lys Arg Ser Gln Tyr Pro Glu Ile Ile Phe Leu Gly Thr 
        435                 440                 445             


Gly Ser Ala Ile Pro Met Lys Ile Arg Asn Val Ser Ala Thr Leu Val 
    450                 455                 460                 


Asn Ile Ser Pro Asp Thr Ser Leu Leu Leu Asp Cys Gly Glu Gly Thr 
465                 470                 475                 480 


Phe Gly Gln Leu Cys Arg His Tyr Gly Asp Gln Val Asp Arg Val Leu 
                485                 490                 495     


Gly Thr Leu Ala Ala Val Phe Val Ser His Leu His Ala Asp His His 
            500                 505                 510         


Thr Gly Leu Pro Ser Ile Leu Leu Gln Arg Glu Arg Ala Leu Ala Ser 
        515                 520                 525             


Leu Gly Lys Pro Leu His Pro Leu Leu Val Val Ala Pro Asn Gln Leu 
    530                 535                 540                 


Lys Ala Trp Leu Gln Gln Tyr His Asn Gln Cys Gln Glu Val Leu His 
545                 550                 555                 560 


His Ile Ser Met Ile Pro Ala Lys Cys Leu Gln Glu Gly Ala Glu Ile 
                565                 570                 575     


Ser Ser Pro Ala Val Glu Arg Leu Ile Ser Ser Leu Leu Arg Thr Cys 
            580                 585                 590         


Asp Leu Glu Glu Phe Gln Thr Cys Leu Val Arg His Cys Lys His Ala 
        595                 600                 605             


Phe Gly Cys Ala Leu Val His Thr Ser Gly Trp Lys Val Val Tyr Ser 
    610                 615                 620                 


Gly Asp Thr Met Pro Cys Glu Ala Leu Val Arg Met Gly Lys Asp Ala 
625                 630                 635                 640 


Thr Leu Leu Ile His Glu Ala Thr Leu Glu Asp Gly Leu Glu Glu Glu 
                645                 650                 655     


Ala Val Glu Lys Thr His Ser Thr Thr Ser Gln Ala Ile Ser Val Gly 
            660                 665                 670         


Met Arg Met Asn Ala Glu Phe Ile Met Leu Asn His Phe Ser Gln Arg 
        675                 680                 685             


Tyr Ala Lys Val Pro Leu Phe Ser Pro Asn Phe Ser Glu Lys Val Gly 
    690                 695                 700                 


Val Ala Phe Asp His Met Lys Val Cys Phe Gly Asp Phe Pro Thr Met 
705                 710                 715                 720 


Pro Lys Leu Ile Pro Pro Leu Lys Ala Leu Phe Ala Gly Asp Ile Glu 
                725                 730                 735     


Glu Met Glu Glu Arg Arg Glu Lys Arg Glu Leu Arg Gln Val Arg Ala 
            740                 745                 750         


Ala Leu Leu Ser Arg Glu Leu Ala Gly Gly Leu Glu Asp Gly Glu Pro 
        755                 760                 765             


Gln Gln Lys Arg Ala His Thr Glu Glu Pro Gln Ala Lys Lys Val Arg 
    770                 775                 780                 


Ala Gln 
785     


<210>  3492
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELANE__Homo_sapiens__NP_001963

<400>  3492

Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly 
            20                  25                  30          


Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln 
        35                  40                  45              


Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe 
    50                  55                  60                  


Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val 
65                  70                  75                  80  


Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg 
                85                  90                  95      


Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val 
            100                 105                 110         


Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr 
        115                 120                 125             


Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg 
    130                 135                 140                 


Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly 
145                 150                 155                 160 


Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val 
                165                 170                 175     


Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly 
            180                 185                 190         


Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys 
        195                 200                 205             


Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn 
225                 230                 235                 240 


Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His 
                245                 250                 255     


Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His 
            260                 265         


<210>  3493
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELAVL1__Homo_sapiens__NP_001410

<400>  3493

Met Ser Asn Gly Tyr Glu Asp His Met Ala Glu Asp Cys Arg Gly Asp 
1               5                   10                  15      


Ile Gly Arg Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln Asn Met Thr 
            20                  25                  30          


Gln Asp Glu Leu Arg Ser Leu Phe Ser Ser Ile Gly Glu Val Glu Ser 
        35                  40                  45              


Ala Lys Leu Ile Arg Asp Lys Val Ala Gly His Ser Leu Gly Tyr Gly 
    50                  55                  60                  


Phe Val Asn Tyr Val Thr Ala Lys Asp Ala Glu Arg Ala Ile Asn Thr 
65                  70                  75                  80  


Leu Asn Gly Leu Arg Leu Gln Ser Lys Thr Ile Lys Val Ser Tyr Ala 
                85                  90                  95      


Arg Pro Ser Ser Glu Val Ile Lys Asp Ala Asn Leu Tyr Ile Ser Gly 
            100                 105                 110         


Leu Pro Arg Thr Met Thr Gln Lys Asp Val Glu Asp Met Phe Ser Arg 
        115                 120                 125             


Phe Gly Arg Ile Ile Asn Ser Arg Val Leu Val Asp Gln Thr Thr Gly 
    130                 135                 140                 


Leu Ser Arg Gly Val Ala Phe Ile Arg Phe Asp Lys Arg Ser Glu Ala 
145                 150                 155                 160 


Glu Glu Ala Ile Thr Ser Phe Asn Gly His Lys Pro Pro Gly Ser Ser 
                165                 170                 175     


Glu Pro Ile Thr Val Lys Phe Ala Ala Asn Pro Asn Gln Asn Lys Asn 
            180                 185                 190         


Val Ala Leu Leu Ser Gln Leu Tyr His Ser Pro Ala Arg Arg Phe Gly 
        195                 200                 205             


Gly Pro Val His His Gln Ala Gln Arg Phe Arg Phe Ser Pro Met Gly 
    210                 215                 220                 


Val Asp His Met Ser Gly Leu Ser Gly Val Asn Val Pro Gly Asn Ala 
225                 230                 235                 240 


Ser Ser Gly Trp Cys Ile Phe Ile Tyr Asn Leu Gly Gln Asp Ala Asp 
                245                 250                 255     


Glu Gly Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala Val Thr Asn 
            260                 265                 270         


Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly 
        275                 280                 285             


Phe Val Thr Met Thr Asn Tyr Glu Glu Ala Ala Met Ala Ile Ala Ser 
    290                 295                 300                 


Leu Asn Gly Tyr Arg Leu Gly Asp Lys Ile Leu Gln Val Ser Phe Lys 
305                 310                 315                 320 


Thr Asn Lys Ser His Lys 
                325     


<210>  3494
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELAVL2__Homo_sapiens__NP_001164668

<400>  3494

Met Glu Thr Gln Leu Ser Asn Gly Pro Thr Cys Asn Asn Thr Ala Asn 
1               5                   10                  15      


Gly Pro Thr Thr Ile Asn Asn Asn Cys Ser Ser Pro Val Asp Ser Gly 
            20                  25                  30          


Asn Thr Glu Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
        35                  40                  45              


Asn Met Thr Gln Glu Glu Leu Lys Ser Leu Phe Gly Ser Ile Gly Glu 
    50                  55                  60                  


Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala 
                85                  90                  95      


Ile Asn Thr Leu Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val 
            100                 105                 110         


Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
        115                 120                 125             


Val Ser Gly Leu Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu 
    130                 135                 140                 


Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
145                 150                 155                 160 


Val Thr Gly Ile Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                165                 170                 175     


Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Pro 
            180                 185                 190         


Gly Ala Thr Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
        195                 200                 205             


Lys Thr Asn Gln Ala Ile Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg 
    210                 215                 220                 


Arg Tyr Pro Gly Pro Leu Ala Gln Gln Ala Gln Arg Phe Arg Phe Ser 
225                 230                 235                 240 


Pro Met Thr Ile Asp Gly Met Thr Ser Leu Ala Gly Ile Asn Ile Pro 
                245                 250                 255     


Gly His Pro Gly Thr Gly Trp Cys Ile Phe Val Tyr Asn Leu Ala Pro 
            260                 265                 270         


Asp Ala Asp Glu Ser Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala 
        275                 280                 285             


Val Thr Asn Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys 
    290                 295                 300                 


Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp Glu Ala Ala Met Ala 
305                 310                 315                 320 


Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Asp Arg Val Leu Gln Val 
                325                 330                 335     


Ser Phe Lys Thr Asn Lys Thr His Lys Ala 
            340                 345     


<210>  3495
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELAVL3__Homo_sapiens__NP_001411

<400>  3495

Met Val Thr Gln Ile Leu Gly Ala Met Glu Ser Gln Val Gly Gly Gly 
1               5                   10                  15      


Pro Ala Gly Pro Ala Leu Pro Asn Gly Pro Leu Leu Gly Thr Asn Gly 
            20                  25                  30          


Ala Thr Asp Asp Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln 
        35                  40                  45              


Asn Met Thr Gln Asp Glu Phe Lys Ser Leu Phe Gly Ser Ile Gly Asp 
    50                  55                  60                  


Ile Glu Ser Cys Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu 
65                  70                  75                  80  


Gly Tyr Gly Phe Val Asn Tyr Ser Asp Pro Asn Asp Ala Asp Lys Ala 
                85                  90                  95      


Ile Asn Thr Leu Asn Gly Leu Lys Leu Gln Thr Lys Thr Ile Lys Val 
            100                 105                 110         


Ser Tyr Ala Arg Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr 
        115                 120                 125             


Val Ser Gly Leu Pro Lys Thr Met Ser Gln Lys Glu Met Glu Gln Leu 
    130                 135                 140                 


Phe Ser Gln Tyr Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln 
145                 150                 155                 160 


Val Thr Gly Val Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg 
                165                 170                 175     


Ile Glu Ala Glu Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Leu 
            180                 185                 190         


Gly Ala Ala Glu Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln 
        195                 200                 205             


Lys Thr Gly Gln Ala Leu Leu Thr His Leu Tyr Gln Ser Ser Ala Arg 
    210                 215                 220                 


Arg Tyr Ala Gly Pro Leu His His Gln Thr Gln Arg Phe Arg Leu Asp 
225                 230                 235                 240 


Asn Leu Leu Asn Met Ala Tyr Gly Val Lys Ser Pro Leu Ser Leu Ile 
                245                 250                 255     


Ala Arg Phe Ser Pro Ile Ala Ile Asp Gly Met Ser Gly Leu Ala Gly 
            260                 265                 270         


Val Gly Leu Ser Gly Gly Ala Ala Gly Ala Gly Trp Cys Ile Phe Val 
        275                 280                 285             


Tyr Asn Leu Ser Pro Glu Ala Asp Glu Ser Val Leu Trp Gln Leu Phe 
    290                 295                 300                 


Gly Pro Phe Gly Ala Val Thr Asn Val Lys Val Ile Arg Asp Phe Thr 
305                 310                 315                 320 


Thr Asn Lys Cys Lys Gly Phe Gly Phe Val Thr Met Thr Asn Tyr Asp 
                325                 330                 335     


Glu Ala Ala Met Ala Ile Ala Ser Leu Asn Gly Tyr Arg Leu Gly Glu 
            340                 345                 350         


Arg Val Leu Gln Val Ser Phe Lys Thr Ser Lys Gln His Lys Ala 
        355                 360                 365         


<210>  3496
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELAVL4__Homo_sapiens__NP_001281277

<400>  3496

Met Glu Trp Asn Gly Leu Lys Met Ile Ile Ser Thr Met Glu Pro Gln 
1               5                   10                  15      


Val Ser Asn Gly Pro Thr Ser Asn Thr Ser Asn Gly Pro Ser Ser Asn 
            20                  25                  30          


Asn Arg Asn Cys Pro Ser Pro Met Gln Thr Gly Ala Thr Thr Asp Asp 
        35                  40                  45              


Ser Lys Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln Asn Met Thr Gln 
    50                  55                  60                  


Glu Glu Phe Arg Ser Leu Phe Gly Ser Ile Gly Glu Ile Glu Ser Cys 
65                  70                  75                  80  


Lys Leu Val Arg Asp Lys Ile Thr Gly Gln Ser Leu Gly Tyr Gly Phe 
                85                  90                  95      


Val Asn Tyr Ile Asp Pro Lys Asp Ala Glu Lys Ala Ile Asn Thr Leu 
            100                 105                 110         


Asn Gly Leu Arg Leu Gln Thr Lys Thr Ile Lys Val Ser Tyr Ala Arg 
        115                 120                 125             


Pro Ser Ser Ala Ser Ile Arg Asp Ala Asn Leu Tyr Val Ser Gly Leu 
    130                 135                 140                 


Pro Lys Thr Met Thr Gln Lys Glu Leu Glu Gln Leu Phe Ser Gln Tyr 
145                 150                 155                 160 


Gly Arg Ile Ile Thr Ser Arg Ile Leu Val Asp Gln Val Thr Gly Val 
                165                 170                 175     


Ser Arg Gly Val Gly Phe Ile Arg Phe Asp Lys Arg Ile Glu Ala Glu 
            180                 185                 190         


Glu Ala Ile Lys Gly Leu Asn Gly Gln Lys Pro Ser Gly Ala Thr Glu 
        195                 200                 205             


Pro Ile Thr Val Lys Phe Ala Asn Asn Pro Ser Gln Lys Ser Ser Gln 
    210                 215                 220                 


Ala Leu Leu Ser Gln Leu Tyr Gln Ser Pro Asn Arg Arg Tyr Pro Gly 
225                 230                 235                 240 


Pro Leu His His Gln Ala Gln Arg Phe Arg Leu Asp Asn Leu Leu Asn 
                245                 250                 255     


Met Ala Tyr Gly Val Lys Arg Phe Ser Pro Ile Thr Ile Asp Gly Met 
            260                 265                 270         


Thr Ser Leu Val Gly Met Asn Ile Pro Gly His Thr Gly Thr Gly Trp 
        275                 280                 285             


Cys Ile Phe Val Tyr Asn Leu Ser Pro Asp Ser Asp Glu Ser Val Leu 
    290                 295                 300                 


Trp Gln Leu Phe Gly Pro Phe Gly Ala Val Asn Asn Val Lys Val Ile 
305                 310                 315                 320 


Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly Phe Val Thr Met 
                325                 330                 335     


Thr Asn Tyr Asp Glu Ala Ala Met Ala Ile Ala Ser Leu Asn Gly Tyr 
            340                 345                 350         


Arg Leu Gly Asp Arg Val Leu Gln Val Ser Phe Lys Thr Asn Lys Ala 
        355                 360                 365             


His Lys Ser 
    370     


<210>  3497
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELF1__Homo_sapiens__NP_001138825

<400>  3497

Met Ala Ala Val Val Gln Gln Asn Asp Leu Val Phe Glu Phe Ala Ser 
1               5                   10                  15      


Asn Val Met Glu Asp Glu Arg Gln Leu Gly Asp Pro Ala Ile Phe Pro 
            20                  25                  30          


Ala Val Ile Val Glu His Val Pro Gly Ala Asp Ile Leu Asn Ser Tyr 
        35                  40                  45              


Ala Gly Leu Ala Cys Val Glu Glu Pro Asn Asp Met Ile Thr Glu Ser 
    50                  55                  60                  


Ser Leu Asp Val Ala Glu Glu Glu Ile Ile Asp Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Ile Thr Leu Thr Val Glu Ala Ser Cys His Asp Gly Asp Glu Thr Ile 
                85                  90                  95      


Glu Thr Ile Glu Ala Ala Glu Ala Leu Leu Asn Met Asp Ser Pro Gly 
            100                 105                 110         


Pro Met Leu Asp Glu Lys Arg Ile Asn Gly Ile Pro Glu Val Met Glu 
        115                 120                 125             


Thr Gln Gln Val Gln Glu Lys Tyr Ala Asp Ser Pro Gly Ala Ser Ser 
    130                 135                 140                 


Pro Glu Gln Pro Lys Arg Lys Lys Gly Arg Lys Thr Lys Pro Pro Arg 
145                 150                 155                 160 


Pro Asp Ser Pro Ala Thr Thr Pro Asn Ile Ser Val Lys Lys Lys Asn 
                165                 170                 175     


Lys Asp Gly Lys Gly Asn Thr Ile Tyr Leu Trp Glu Phe Leu Leu Ala 
            180                 185                 190         


Leu Leu Gln Asp Lys Ala Thr Cys Pro Lys Tyr Ile Lys Trp Thr Gln 
        195                 200                 205             


Arg Glu Lys Gly Ile Phe Lys Leu Val Asp Ser Lys Ala Val Ser Arg 
    210                 215                 220                 


Leu Trp Gly Lys His Lys Asn Lys Pro Asp Met Asn Tyr Glu Thr Met 
225                 230                 235                 240 


Gly Arg Ala Leu Arg Tyr Tyr Tyr Gln Arg Gly Ile Leu Ala Lys Val 
                245                 250                 255     


Glu Gly Gln Arg Leu Val Tyr Gln Phe Lys Glu Met Pro Lys Asp Leu 
            260                 265                 270         


Ile Tyr Ile Asn Asp Glu Asp Pro Ser Ser Ser Ile Glu Ser Ser Asp 
        275                 280                 285             


Pro Ser Leu Ser Ser Ser Ala Thr Ser Asn Arg Asn Gln Thr Ser Arg 
    290                 295                 300                 


Ser Arg Val Ser Ser Ser Pro Gly Val Lys Gly Gly Ala Thr Thr Val 
305                 310                 315                 320 


Leu Lys Pro Gly Asn Ser Lys Ala Ala Lys Pro Lys Asp Pro Val Glu 
                325                 330                 335     


Val Ala Gln Pro Ser Glu Val Leu Arg Thr Val Gln Pro Thr Gln Ser 
            340                 345                 350         


Pro Tyr Pro Thr Gln Leu Phe Arg Thr Val His Val Val Gln Pro Val 
        355                 360                 365             


Gln Ala Val Pro Glu Gly Glu Ala Ala Arg Thr Ser Thr Met Gln Asp 
    370                 375                 380                 


Glu Thr Leu Asn Ser Ser Val Gln Ser Ile Arg Thr Ile Gln Ala Pro 
385                 390                 395                 400 


Thr Gln Val Pro Val Val Val Ser Pro Arg Asn Gln Gln Leu His Thr 
                405                 410                 415     


Val Thr Leu Gln Thr Val Pro Leu Thr Thr Val Ile Ala Ser Thr Asp 
            420                 425                 430         


Pro Ser Ala Gly Thr Gly Ser Gln Lys Phe Ile Leu Gln Ala Ile Pro 
        435                 440                 445             


Ser Ser Gln Pro Met Thr Val Leu Lys Glu Asn Val Met Leu Gln Ser 
    450                 455                 460                 


Gln Lys Ala Gly Ser Pro Pro Ser Ile Val Leu Gly Pro Ala Gln Val 
465                 470                 475                 480 


Gln Gln Val Leu Thr Ser Asn Val Gln Thr Ile Cys Asn Gly Thr Val 
                485                 490                 495     


Ser Val Ala Ser Ser Pro Ser Phe Ser Ala Thr Ala Pro Val Val Thr 
            500                 505                 510         


Phe Ser Pro Arg Ser Ser Gln Leu Val Ala His Pro Pro Gly Thr Val 
        515                 520                 525             


Ile Thr Ser Val Ile Lys Thr Gln Glu Thr Lys Thr Leu Thr Gln Glu 
    530                 535                 540                 


Val Glu Lys Lys Glu Ser Glu Asp His Leu Lys Glu Asn Thr Glu Lys 
545                 550                 555                 560 


Thr Glu Gln Gln Pro Gln Pro Tyr Val Met Val Val Ser Ser Ser Asn 
                565                 570                 575     


Gly Phe Thr Ser Gln Val Ala Met Lys Gln Asn Glu Leu Leu Glu Pro 
            580                 585                 590         


Asn Ser Phe 
        595 


<210>  3498
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELF2__Homo_sapiens__NP_001263386

<400>  3498

Met Ala Thr Ser Leu His Glu Gly Pro Thr Asn Gln Leu Asp Leu Leu 
1               5                   10                  15      


Ile Arg Ala Val Glu Ala Ser Val His Ser Ser Asn Ala His Cys Thr 
            20                  25                  30          


Asp Lys Thr Ile Glu Ala Ala Glu Ala Leu Leu His Met Glu Ser Pro 
        35                  40                  45              


Thr Cys Leu Arg Asp Ser Arg Ser Pro Val Glu Val Phe Val Pro Pro 
    50                  55                  60                  


Cys Val Ser Thr Pro Glu Phe Ile His Ala Ala Met Arg Pro Asp Val 
65                  70                  75                  80  


Ile Thr Glu Thr Val Val Glu Val Ser Thr Glu Glu Ser Glu Pro Met 
                85                  90                  95      


Asp Thr Ser Pro Ile Pro Thr Ser Pro Asp Ser His Glu Pro Met Lys 
            100                 105                 110         


Lys Lys Lys Gly Asn Thr Thr Tyr Leu Trp Glu Phe Leu Leu Asp Leu 
        115                 120                 125             


Leu Gln Asp Lys Asn Thr Cys Pro Arg Tyr Ile Lys Trp Thr Gln Arg 
    130                 135                 140                 


Glu Lys Gly Ile Phe Lys Leu Val Asp Ser Lys Ala Val Ser Lys Leu 
145                 150                 155                 160 


Trp Gly Lys His Lys Asn Lys Pro Asp Met Asn Tyr Glu Thr Met Gly 
                165                 170                 175     


Arg Ala Leu Arg Tyr Tyr Tyr Gln Arg Gly Ile Leu Ala Lys Val Glu 
            180                 185                 190         


Gly Gln Arg Leu Val Tyr Gln Phe Lys Asp Met Pro Lys Asn Ile Val 
        195                 200                 205             


Val Ile Asp Asp Asp Lys Ser Glu Thr Cys Asn Glu Asp Leu Ala Gly 
    210                 215                 220                 


Thr Thr Asp Glu Lys Ser Leu Glu Arg Val Ser Leu Ser Ala Glu Ser 
225                 230                 235                 240 


Leu Leu Lys Ala Ala Ser Ser Val Arg Ser Gly Lys Asn Ser Ser Pro 
                245                 250                 255     


Ile Asn Cys Ser Arg Ala Glu Lys Gly Val Ala Arg Val Val Asn Ile 
            260                 265                 270         


Thr Ser Pro Gly His Asp Ala Ser Ser Arg Ser Pro Thr Thr Thr Ala 
        275                 280                 285             


Ser Val Ser Ala Thr Ala Ala Pro Arg Thr Val Arg Val Ala Met Gln 
    290                 295                 300                 


Val Pro Val Val Met Thr Ser Leu Gly Gln Lys Ile Ser Thr Val Ala 
305                 310                 315                 320 


Val Gln Ser Val Asn Ala Gly Ala Pro Leu Ile Thr Ser Thr Ser Pro 
                325                 330                 335     


Thr Thr Ala Thr Ser Pro Lys Val Val Ile Gln Thr Ile Pro Thr Val 
            340                 345                 350         


Met Pro Ala Ser Thr Glu Asn Gly Asp Lys Ile Thr Met Gln Pro Ala 
        355                 360                 365             


Lys Ile Ile Thr Ile Pro Ala Thr Gln Leu Ala Gln Cys Gln Leu Gln 
    370                 375                 380                 


Thr Lys Ser Asn Leu Thr Gly Ser Gly Ser Ile Asn Ile Val Gly Thr 
385                 390                 395                 400 


Pro Leu Ala Val Arg Ala Leu Thr Pro Val Ser Ile Ala His Gly Thr 
                405                 410                 415     


Pro Val Met Arg Leu Ser Met Pro Thr Gln Gln Ala Ser Gly Gln Thr 
            420                 425                 430         


Pro Pro Arg Val Ile Ser Ala Val Ile Lys Gly Pro Glu Val Lys Ser 
        435                 440                 445             


Glu Ala Val Ala Lys Lys Gln Glu His Asp Val Lys Thr Leu Gln Leu 
    450                 455                 460                 


Val Glu Glu Lys Pro Ala Asp Gly Asn Lys Thr Val Thr His Val Val 
465                 470                 475                 480 


Val Val Ser Ala Pro Ser Ala Ile Ala Leu Pro Val Thr Met Lys Thr 
                485                 490                 495     


Glu Gly Leu Val Thr Cys Glu Lys 
            500                 


<210>  3499
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELF3__Homo_sapiens__NP_001107781

<400>  3499

Met Ala Ala Thr Cys Glu Ile Ser Asn Ile Phe Ser Asn Tyr Phe Ser 
1               5                   10                  15      


Ala Met Tyr Ser Ser Glu Asp Ser Thr Leu Ala Ser Val Pro Pro Ala 
            20                  25                  30          


Ala Thr Phe Gly Ala Asp Asp Leu Val Leu Thr Leu Ser Asn Pro Gln 
        35                  40                  45              


Met Ser Leu Glu Gly Thr Glu Lys Ala Ser Trp Leu Gly Glu Gln Pro 
    50                  55                  60                  


Gln Phe Trp Ser Lys Thr Gln Val Leu Asp Trp Ile Ser Tyr Gln Val 
65                  70                  75                  80  


Glu Lys Asn Lys Tyr Asp Ala Ser Ala Ile Asp Phe Ser Arg Cys Asp 
                85                  90                  95      


Met Asp Gly Ala Thr Leu Cys Asn Cys Ala Leu Glu Glu Leu Arg Leu 
            100                 105                 110         


Val Phe Gly Pro Leu Gly Asp Gln Leu His Ala Gln Leu Arg Asp Leu 
        115                 120                 125             


Thr Ser Ser Ser Ser Asp Glu Leu Ser Trp Ile Ile Glu Leu Leu Glu 
    130                 135                 140                 


Lys Asp Gly Met Ala Phe Gln Glu Ala Leu Asp Pro Gly Pro Phe Asp 
145                 150                 155                 160 


Gln Gly Ser Pro Phe Ala Gln Glu Leu Leu Asp Asp Gly Gln Gln Ala 
                165                 170                 175     


Ser Pro Tyr His Pro Gly Ser Cys Gly Ala Gly Ala Pro Ser Pro Gly 
            180                 185                 190         


Ser Ser Asp Val Ser Thr Ala Gly Thr Gly Ala Ser Arg Ser Ser His 
        195                 200                 205             


Ser Ser Asp Ser Gly Gly Ser Asp Val Asp Leu Asp Pro Thr Asp Gly 
    210                 215                 220                 


Lys Leu Phe Pro Ser Asp Gly Phe Arg Asp Cys Lys Lys Gly Asp Pro 
225                 230                 235                 240 


Lys His Gly Lys Arg Lys Arg Gly Arg Pro Arg Lys Leu Ser Lys Glu 
                245                 250                 255     


Tyr Trp Asp Cys Leu Glu Gly Lys Lys Ser Lys His Ala Pro Arg Gly 
            260                 265                 270         


Thr His Leu Trp Glu Phe Ile Arg Asp Ile Leu Ile His Pro Glu Leu 
        275                 280                 285             


Asn Glu Gly Leu Met Lys Trp Glu Asn Arg His Glu Gly Val Phe Lys 
    290                 295                 300                 


Phe Leu Arg Ser Glu Ala Val Ala Gln Leu Trp Gly Gln Lys Lys Lys 
305                 310                 315                 320 


Asn Ser Asn Met Thr Tyr Glu Lys Leu Ser Arg Ala Met Arg Tyr Tyr 
                325                 330                 335     


Tyr Lys Arg Glu Ile Leu Glu Arg Val Asp Gly Arg Arg Leu Val Tyr 
            340                 345                 350         


Lys Phe Gly Lys Asn Ser Ser Gly Trp Lys Glu Glu Glu Val Leu Gln 
        355                 360                 365             


Ser Arg Asn 
    370     


<210>  3500
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELF4__Homo_sapiens__XP_005262446

<400>  3500

Met Ala Ile Thr Leu Gln Pro Ser Asp Leu Ile Phe Glu Phe Ala Ser 
1               5                   10                  15      


Asn Gly Met Asp Asp Asp Ile His Gln Leu Glu Asp Pro Ser Val Phe 
            20                  25                  30          


Pro Ala Val Ile Val Glu Gln Val Pro Tyr Pro Asp Leu Leu His Leu 
        35                  40                  45              


Tyr Ser Gly Leu Glu Leu Asp Asp Val His Asn Gly Ile Ile Thr Asp 
    50                  55                  60                  


Gly Thr Leu Cys Met Thr Gln Asp Gln Ile Leu Glu Gly Ser Phe Leu 
65                  70                  75                  80  


Leu Thr Asp Asp Asn Glu Ala Thr Ser His Thr Met Ser Thr Ala Glu 
                85                  90                  95      


Val Leu Leu Asn Met Glu Ser Pro Ser Asp Ile Leu Asp Glu Lys Gln 
            100                 105                 110         


Ile Phe Ser Thr Ser Glu Met Leu Pro Asp Ser Asp Pro Ala Pro Ala 
        115                 120                 125             


Val Thr Leu Pro Asn Tyr Leu Phe Pro Ala Ser Glu Pro Asp Ala Leu 
    130                 135                 140                 


Asn Arg Ala Gly Asp Thr Ser Asp Gln Glu Gly His Ser Leu Glu Glu 
145                 150                 155                 160 


Lys Ala Ser Arg Glu Glu Ser Ala Lys Lys Thr Gly Lys Ser Lys Lys 
                165                 170                 175     


Arg Ile Arg Lys Thr Lys Gly Asn Arg Ser Thr Ser Pro Val Thr Asp 
            180                 185                 190         


Pro Ser Ile Pro Ile Arg Lys Lys Ser Lys Asp Gly Lys Gly Ser Thr 
        195                 200                 205             


Ile Tyr Leu Trp Glu Phe Leu Leu Ala Leu Leu Gln Asp Arg Asn Thr 
    210                 215                 220                 


Cys Pro Lys Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly Ile Phe Lys 
225                 230                 235                 240 


Leu Val Asp Ser Lys Ala Val Ser Lys Leu Trp Gly Lys Gln Lys Asn 
                245                 250                 255     


Lys Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu Arg Tyr Tyr 
            260                 265                 270         


Tyr Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg Leu Val Tyr 
        275                 280                 285             


Gln Phe Lys Glu Met Pro Lys Asp Leu Val Val Ile Glu Asp Glu Asp 
    290                 295                 300                 


Glu Ser Ser Glu Ala Thr Ala Ala Pro Pro Gln Ala Ser Thr Ala Ser 
305                 310                 315                 320 


Val Ala Ser Ala Ser Thr Thr Arg Arg Thr Ser Ser Arg Val Ser Ser 
                325                 330                 335     


Arg Ser Ala Pro Gln Gly Lys Gly Ser Ser Ser Trp Glu Lys Pro Lys 
            340                 345                 350         


Ile Gln His Val Gly Leu Gln Pro Ser Ala Ser Leu Glu Leu Gly Pro 
        355                 360                 365             


Ser Leu Asp Glu Glu Ile Pro Thr Thr Ser Thr Met Leu Val Ser Pro 
    370                 375                 380                 


Ala Glu Gly Gln Val Lys Leu Thr Lys Ala Val Ser Ala Ser Ser Val 
385                 390                 395                 400 


Pro Ser Asn Ile His Leu Gly Val Ala Pro Val Gly Ser Gly Ser Ala 
                405                 410                 415     


Leu Thr Leu Gln Thr Ile Pro Leu Thr Thr Val Leu Thr Asn Gly Pro 
            420                 425                 430         


Pro Ala Ser Thr Thr Ala Pro Thr Gln Leu Val Leu Gln Ser Val Pro 
        435                 440                 445             


Ala Ala Ser Thr Phe Lys Asp Thr Phe Thr Leu Gln Ala Ser Phe Pro 
    450                 455                 460                 


Leu Asn Ala Ser Phe Gln Asp Ser Gln Val Ala Ala Pro Gly Ala Pro 
465                 470                 475                 480 


Leu Ile Leu Ser Gly Leu Pro Gln Leu Leu Ala Gly Ala Asn Arg Pro 
                485                 490                 495     


Thr Asn Pro Ala Pro Pro Thr Val Thr Gly Ala Gly Pro Ala Gly Pro 
            500                 505                 510         


Ser Ser Gln Pro Pro Gly Thr Val Ile Ala Ala Phe Ile Arg Thr Ser 
        515                 520                 525             


Gly Thr Thr Ala Ala Pro Arg Val Lys Glu Gly Pro Leu Arg Ser Ser 
    530                 535                 540                 


Ser Tyr Val Gln Gly Met Val Thr Gly Ala Pro Met Glu Gly Leu Leu 
545                 550                 555                 560 


Val Pro Glu Glu Thr Leu Arg Glu Leu Leu Arg Asp Gln Ala His Leu 
                565                 570                 575     


Gln Pro Leu Pro Thr Gln Val Val Ser Arg Gly Ser His Asn Pro Ser 
            580                 585                 590         


Leu Leu Gly Asn Gln Thr Leu Ser Pro Pro Ser Arg Pro Thr Val Gly 
        595                 600                 605             


Leu Thr Pro Val Ala Glu Leu Glu Leu Ser Ser Gly Ser Gly Ser Leu 
    610                 615                 620                 


Leu Met Ala Glu Pro Ser Val Thr Thr Ser Gly Ser Leu Leu Thr Arg 
625                 630                 635                 640 


Ser Pro Thr Pro Ala Pro Phe Ser Pro Phe Asn Pro Thr Ser Leu Ile 
                645                 650                 655     


Lys Met Glu Pro His Asp Ile 
            660             


<210>  3501
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELF5__Homo_sapiens__NP_001230009

<400>  3501

Met Leu Asp Ser Val Thr His Ser Thr Phe Leu Pro Asn Ala Ser Phe 
1               5                   10                  15      


Cys Asp Pro Leu Met Ser Trp Thr Asp Leu Phe Ser Asn Glu Glu Tyr 
            20                  25                  30          


Tyr Pro Ala Phe Glu His Gln Thr Asp Ala Asp Ser Asn Cys Leu Lys 
        35                  40                  45              


Thr Ser Gly Ile Lys Ser Gln Asp Cys His Ser His Ser Arg Thr Ser 
    50                  55                  60                  


Leu Gln Ser Ser His Leu Trp Glu Phe Val Arg Asp Leu Leu Leu Ser 
65                  70                  75                  80  


Pro Glu Glu Asn Cys Gly Ile Leu Glu Trp Glu Asp Arg Glu Gln Gly 
                85                  90                  95      


Ile Phe Arg Val Val Lys Ser Glu Ala Leu Ala Lys Met Trp Gly Gln 
            100                 105                 110         


Arg Lys Lys Asn Asp Arg Met Thr Tyr Glu Lys Leu Ser Arg Ala Leu 
        115                 120                 125             


Arg Tyr Tyr Tyr Lys Thr Gly Ile Leu Glu Arg Val Asp Arg Arg Leu 
    130                 135                 140                 


Val Tyr Lys Phe Gly Lys Asn Ala His Gly Trp Gln Glu Asp Lys Leu 
145                 150                 155                 160 


<210>  3502
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELK1__Homo_sapiens__NP_001244097

<400>  3502

Met Asp Pro Ser Val Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Arg 
1               5                   10                  15      


Glu Gln Gly Asn Gly His Ile Ile Ser Trp Thr Ser Arg Asp Gly Gly 
            20                  25                  30          


Glu Phe Lys Leu Val Asp Ala Glu Glu Val Ala Arg Leu Trp Gly Leu 
        35                  40                  45              


Arg Lys Asn Lys Thr Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
    50                  55                  60                  


Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile Arg Lys Val Ser Gly Gln Lys 
65                  70                  75                  80  


Phe Val Tyr Lys Phe Val Ser Tyr Pro Glu Ser His Cys Ala Pro 
                85                  90                  95  


<210>  3503
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELK3__Homo_sapiens__XP_006719338

<400>  3503

Met Glu Ser Ala Ile Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Asp Gln Lys His Glu His Leu Ile Cys Trp Thr Ser Asn Asp Gly Glu 
            20                  25                  30          


Phe Lys Leu Leu Lys Ala Glu Glu Val Ala Lys Leu Trp Gly Leu Arg 
        35                  40                  45              


Lys Asn Lys Thr Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg 
    50                  55                  60                  


Tyr Tyr Tyr Asp Lys Asn Ile Ile Lys Lys Val Ile Gly Gln Lys Phe 
65                  70                  75                  80  


Val Tyr Lys Phe Val Ser Phe Pro Glu Ile Leu Lys Met Asp Pro His 
                85                  90                  95      


Ala Val Glu Ile Ser Arg Glu Ser Leu Leu Leu Gln Asp Ser Asp Cys 
            100                 105                 110         


Lys Ala Ser Pro Glu Gly Arg Glu Ala His Lys His Gly Leu Ala Ala 
        115                 120                 125             


Leu Arg Ser Thr Ser Arg Asn Glu Tyr Ile His Ser Gly Leu Tyr Ser 
    130                 135                 140                 


Ser Phe Thr Ile Asn Ser Leu Gln Asn Pro Pro Asp Ala Phe Lys Ala 
145                 150                 155                 160 


Ile Lys Thr Glu Lys Leu Glu Glu Pro Pro Glu Asp Ser Pro Pro Val 
                165                 170                 175     


Glu Glu Val Arg Thr Val Ile Arg Phe Val Thr Asn Lys Thr Asp Lys 
            180                 185                 190         


His Val Thr Arg Pro Val Val Ser Leu Pro Ser Thr Ser Glu Ala Ala 
        195                 200                 205             


Ala Ala Ser Ala Phe Leu Ala Ser Ser Val Ser Ala Lys Ile Ser Ser 
    210                 215                 220                 


Leu Met Leu Pro Asn Ala Ala Ser Ile Ser Ser Ala Ser Pro Phe Ser 
225                 230                 235                 240 


Ser Arg Ser Pro Ser Leu Ser Pro Asn Ser Pro Leu Pro Ser Glu His 
                245                 250                 255     


Arg Ser Leu Phe Leu Glu Ala Ala Cys His Asp Ser Asp Ser Leu Glu 
            260                 265                 270         


Pro Leu Asn Leu Ser Ser Gly Ser Lys Thr Lys Ser Pro Ser Leu Pro 
        275                 280                 285             


Pro Lys Ala Lys Lys Pro Lys Gly Leu Glu Ile Ser Ala Pro Pro Leu 
    290                 295                 300                 


Val Leu Ser Gly Thr Asp Ile Gly Ser Ile Ala Leu Asn Ser Pro Ala 
305                 310                 315                 320 


Leu Pro Ser Gly Ser Leu Thr Pro Ala Phe Phe Thr Ala Gln Thr Pro 
                325                 330                 335     


Asn Gly Leu Leu Leu Thr Pro Ser Pro Leu Leu Ser Ser Ile His Phe 
            340                 345                 350         


Trp Ser Ser Leu Ser Pro Val Ala Pro Leu Ser Pro Ala Arg Leu Gln 
        355                 360                 365             


Gly Pro Ser Thr Leu Phe Gln Phe Pro Thr Leu Leu Asn Gly His Met 
    370                 375                 380                 


Pro Val Pro Ile Pro Ser Leu Asp Arg Ala Ala Ser Pro Val Leu Leu 
385                 390                 395                 400 


Ser Ser Asn Ser Gln Lys Ser 
                405         


<210>  3504
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELK4__Homo_sapiens__NP_068567

<400>  3504

Met Asp Ser Ala Ile Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Gln 
1               5                   10                  15      


Lys Pro Gln Asn Lys His Met Ile Cys Trp Thr Ser Asn Asp Gly Gln 
            20                  25                  30          


Phe Lys Leu Leu Gln Ala Glu Glu Val Ala Arg Leu Trp Gly Ile Arg 
        35                  40                  45              


Lys Asn Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg 
    50                  55                  60                  


Tyr Tyr Tyr Val Lys Asn Ile Ile Lys Lys Val Asn Gly Gln Lys Phe 
65                  70                  75                  80  


Val Tyr Lys Phe Val Ser Tyr Pro Glu Ile Leu Asn Met Asp Pro Met 
                85                  90                  95      


Thr Val Gly Arg Ile Glu Gly Asp Cys Glu Ser Leu Asn Phe Ser Glu 
            100                 105                 110         


Val Ser Ser Ser Ser Lys Asp Val Glu Asn Gly Gly Lys Asp Lys Pro 
        115                 120                 125             


Pro Gln Pro Gly Ala Lys Thr Ser Ser Arg Asn Asp Tyr Ile His Ser 
    130                 135                 140                 


Gly Leu Tyr Ser Ser Phe Thr Leu Asn Ser Leu Asn Ser Ser Asn Val 
145                 150                 155                 160 


Lys Leu Phe Lys Leu Ile Lys Thr Glu Asn Pro Ala Glu Lys Leu Ala 
                165                 170                 175     


Glu Lys Lys Ser Pro Gln Glu Pro Thr Pro Ser Val Ile Lys Phe Val 
            180                 185                 190         


Thr Thr Pro Ser Lys Lys Pro Pro Val Glu Pro Val Ala Ala Thr Ile 
        195                 200                 205             


Ser Ile Gly Pro Ser Ile Ser Pro Ser Ser Glu Glu Thr Ile Gln Ala 
    210                 215                 220                 


Leu Glu Thr Leu Val Ser Pro Lys Leu Pro Ser Leu Glu Ala Pro Thr 
225                 230                 235                 240 


Ser Ala Ser Asn Val Met Thr Ala Phe Ala Thr Thr Pro Pro Ile Ser 
                245                 250                 255     


Ser Ile Pro Pro Leu Gln Glu Pro Pro Arg Thr Pro Ser Pro Pro Leu 
            260                 265                 270         


Ser Ser His Pro Asp Ile Asp Thr Asp Ile Asp Ser Val Ala Ser Gln 
        275                 280                 285             


Pro Met Glu Leu Pro Glu Asn Leu Ser Leu Glu Pro Lys Asp Gln Asp 
    290                 295                 300                 


Ser Val Leu Leu Glu Lys Asp Lys Val Asn Asn Ser Ser Arg Ser Lys 
305                 310                 315                 320 


Lys Pro Lys Gly Leu Glu Leu Ala Pro Thr Leu Val Ile Thr Ser Ser 
                325                 330                 335     


Asp Pro Ser Pro Leu Gly Ile Leu Ser Pro Ser Leu Pro Thr Ala Ser 
            340                 345                 350         


Leu Thr Pro Ala Phe Phe Ser Gln Val Ala Cys Ser Leu Phe Met Val 
        355                 360                 365             


Ser Pro Leu Leu Ser Phe Ile Cys Pro Phe Lys Gln Ile Gln Asn Leu 
    370                 375                 380                 


Tyr Thr Gln Val Cys Phe Leu Leu Leu Arg Phe Val Leu Glu Arg Leu 
385                 390                 395                 400 


Cys Val Thr Val Met 
                405 


<210>  3505
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELL2__Homo_sapiens__NP_036213

<400>  3505

Met Ala Ala Gly Gly Thr Gly Gly Leu Arg Glu Glu Gln Arg Tyr Gly 
1               5                   10                  15      


Leu Ser Cys Gly Arg Leu Gly Gln Asp Asn Ile Thr Val Leu His Val 
            20                  25                  30          


Lys Leu Thr Glu Thr Ala Ile Arg Ala Leu Glu Thr Tyr Gln Ser His 
        35                  40                  45              


Lys Asn Leu Ile Pro Phe Arg Pro Ser Ile Gln Phe Gln Gly Leu His 
    50                  55                  60                  


Gly Leu Val Lys Ile Pro Lys Asn Asp Pro Leu Asn Glu Val His Asn 
65                  70                  75                  80  


Phe Asn Phe Tyr Leu Ser Asn Val Gly Lys Asp Asn Pro Gln Gly Ser 
                85                  90                  95      


Phe Asp Cys Ile Gln Gln Thr Phe Ser Ser Ser Gly Ala Ser Gln Leu 
            100                 105                 110         


Asn Cys Leu Gly Phe Ile Gln Asp Lys Ile Thr Val Cys Ala Thr Asn 
        115                 120                 125             


Asp Ser Tyr Gln Met Thr Arg Glu Arg Met Thr Gln Ala Glu Glu Glu 
    130                 135                 140                 


Ser Arg Asn Arg Ser Thr Lys Val Ile Lys Pro Gly Gly Pro Tyr Val 
145                 150                 155                 160 


Gly Lys Arg Val Gln Ile Arg Lys Ala Pro Gln Ala Val Ser Asp Thr 
                165                 170                 175     


Val Pro Glu Arg Lys Arg Ser Thr Pro Met Asn Pro Ala Asn Thr Ile 
            180                 185                 190         


Arg Lys Thr His Ser Ser Ser Thr Ile Ser Gln Arg Pro Tyr Arg Asp 
        195                 200                 205             


Arg Val Ile His Leu Leu Ala Leu Lys Ala Tyr Lys Lys Pro Glu Leu 
    210                 215                 220                 


Leu Ala Arg Leu Gln Lys Asp Gly Val Asn Gln Lys Asp Lys Asn Ser 
225                 230                 235                 240 


Leu Gly Ala Ile Leu Gln Gln Val Ala Asn Leu Asn Ser Lys Asp Leu 
                245                 250                 255     


Ser Tyr Thr Leu Lys Asp Tyr Val Phe Lys Glu Leu Gln Arg Asp Trp 
            260                 265                 270         


Pro Gly Tyr Ser Glu Ile Asp Arg Arg Ser Leu Glu Ser Val Leu Ser 
        275                 280                 285             


Arg Lys Leu Asn Pro Ser Gln Asn Ala Ala Gly Thr Ser Arg Ser Glu 
    290                 295                 300                 


Ser Pro Val Cys Ser Ser Arg Asp Ala Val Ser Ser Pro Gln Lys Arg 
305                 310                 315                 320 


Leu Leu Asp Ser Glu Phe Ile Asp Pro Leu Met Asn Lys Lys Ala Arg 
                325                 330                 335     


Ile Ser His Leu Thr Asn Arg Val Pro Pro Thr Leu Asn Gly His Leu 
            340                 345                 350         


Asn Pro Thr Ser Glu Lys Ser Ala Ala Gly Leu Pro Leu Pro Pro Ala 
        355                 360                 365             


Ala Ala Ala Ile Pro Thr Pro Pro Pro Leu Pro Ser Thr Tyr Leu Pro 
    370                 375                 380                 


Ile Ser His Pro Pro Gln Ile Val Asn Ser Asn Ser Asn Ser Pro Ser 
385                 390                 395                 400 


Thr Pro Glu Gly Arg Gly Thr Gln Asp Leu Pro Val Asp Ser Phe Ser 
                405                 410                 415     


Gln Asn Asp Ser Ile Tyr Glu Asp Gln Gln Asp Lys Tyr Thr Ser Arg 
            420                 425                 430         


Thr Ser Leu Glu Thr Leu Pro Pro Gly Ser Val Leu Leu Lys Cys Pro 
        435                 440                 445             


Lys Pro Met Glu Glu Asn His Ser Met Ser His Lys Lys Ser Lys Lys 
    450                 455                 460                 


Lys Ser Lys Lys His Lys Glu Lys Asp Gln Ile Lys Lys His Asp Ile 
465                 470                 475                 480 


Glu Thr Ile Glu Glu Lys Glu Glu Asp Leu Lys Arg Glu Glu Glu Ile 
                485                 490                 495     


Ala Lys Leu Asn Asn Ser Ser Pro Asn Ser Ser Gly Gly Val Lys Glu 
            500                 505                 510         


Asp Cys Thr Ala Ser Met Glu Pro Ser Ala Ile Glu Leu Pro Asp Tyr 
        515                 520                 525             


Leu Ile Lys Tyr Ile Ala Ile Val Ser Tyr Glu Gln Arg Gln Asn Tyr 
    530                 535                 540                 


Lys Asp Asp Phe Asn Ala Glu Tyr Asp Glu Tyr Arg Ala Leu His Ala 
545                 550                 555                 560 


Arg Met Glu Thr Val Ala Arg Arg Phe Ile Lys Leu Asp Ala Gln Arg 
                565                 570                 575     


Lys Arg Leu Ser Pro Gly Ser Lys Glu Tyr Gln Asn Val His Glu Glu 
            580                 585                 590         


Val Leu Gln Glu Tyr Gln Lys Ile Lys Gln Ser Ser Pro Asn Tyr His 
        595                 600                 605             


Glu Glu Lys Tyr Arg Cys Glu Tyr Leu His Asn Lys Leu Ala His Ile 
    610                 615                 620                 


Lys Arg Leu Ile Gly Glu Phe Asp Gln Gln Gln Ala Glu Ser Trp Ser 
625                 630                 635                 640 


<210>  3506
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELL__Homo_sapiens__NP_006523

<400>  3506

Met Ala Ala Leu Lys Glu Asp Arg Ser Tyr Gly Leu Ser Cys Gly Arg 
1               5                   10                  15      


Val Ser Asp Gly Ser Lys Val Ser Val Phe His Val Lys Leu Thr Asp 
            20                  25                  30          


Ser Ala Leu Arg Ala Phe Glu Ser Tyr Arg Ala Arg Gln Asp Ser Val 
        35                  40                  45              


Ser Leu Arg Pro Ser Ile Arg Phe Gln Gly Ser Gln Gly His Ile Ser 
    50                  55                  60                  


Ile Pro Gln Pro Asp Cys Pro Ala Glu Ala Arg Thr Phe Ser Phe Tyr 
65                  70                  75                  80  


Leu Ser Asn Ile Gly Arg Asp Asn Pro Gln Gly Ser Phe Asp Cys Ile 
                85                  90                  95      


Gln Gln Tyr Val Ser Ser His Gly Glu Val His Leu Asp Cys Leu Gly 
            100                 105                 110         


Ser Ile Gln Asp Lys Ile Thr Val Cys Ala Thr Asp Asp Ser Tyr Gln 
        115                 120                 125             


Lys Ala Arg Gln Ser Met Ala Gln Ala Glu Glu Glu Thr Arg Ser Arg 
    130                 135                 140                 


Ser Ala Ile Val Ile Lys Ala Gly Gly Arg Tyr Leu Gly Lys Lys Val 
145                 150                 155                 160 


Gln Phe Arg Lys Pro Ala Pro Gly Ala Thr Asp Ala Val Pro Ser Arg 
                165                 170                 175     


Lys Arg Ala Thr Pro Ile Asn Leu Ala Ser Ala Ile Arg Lys Ser Gly 
            180                 185                 190         


Ala Ser Ala Val Ser Gly Gly Ser Gly Val Ser Gln Arg Pro Phe Arg 
        195                 200                 205             


Asp Arg Val Leu His Leu Leu Ala Leu Arg Pro Tyr Arg Lys Ala Glu 
    210                 215                 220                 


Leu Leu Leu Arg Leu Gln Lys Asp Gly Leu Thr Gln Ala Asp Lys Asp 
225                 230                 235                 240 


Ala Leu Asp Gly Leu Leu Gln Gln Val Ala Asn Met Ser Ala Lys Asp 
                245                 250                 255     


Gly Thr Cys Thr Leu Gln Asp Cys Met Tyr Lys Asp Val Gln Lys Asp 
            260                 265                 270         


Trp Pro Gly Tyr Ser Glu Gly Asp Gln Gln Leu Leu Lys Arg Val Leu 
        275                 280                 285             


Val Arg Lys Leu Cys Gln Pro Gln Ser Thr Gly Ser Leu Leu Gly Asp 
    290                 295                 300                 


Pro Ala Ala Ser Ser Pro Pro Gly Glu Arg Gly Arg Ser Ala Ser Pro 
305                 310                 315                 320 


Pro Gln Lys Arg Leu Gln Pro Pro Asp Phe Ile Asp Pro Leu Ala Asn 
                325                 330                 335     


Lys Lys Pro Arg Ile Ser His Phe Thr Gln Arg Ala Gln Pro Ala Val 
            340                 345                 350         


Asn Gly Lys Leu Gly Val Pro Asn Gly Arg Glu Ala Leu Leu Pro Thr 
        355                 360                 365             


Pro Gly Pro Pro Ala Ser Thr Asp Thr Leu Ser Ser Ser Thr His Leu 
    370                 375                 380                 


Pro Pro Arg Leu Glu Pro Pro Arg Ala His Asp Pro Leu Ala Asp Val 
385                 390                 395                 400 


Ser Asn Asp Leu Gly His Ser Gly Arg Asp Cys Glu His Gly Glu Ala 
                405                 410                 415     


Ala Ala Pro Ala Pro Thr Val Arg Leu Gly Leu Pro Leu Leu Thr Asp 
            420                 425                 430         


Cys Ala Gln Pro Ser Arg Pro His Gly Ser Pro Ser Arg Ser Lys Pro 
        435                 440                 445             


Lys Lys Lys Ser Lys Lys His Lys Asp Lys Glu Arg Ala Ala Glu Asp 
    450                 455                 460                 


Lys Pro Arg Ala Gln Leu Pro Asp Cys Ala Pro Ala Thr His Ala Thr 
465                 470                 475                 480 


Pro Gly Ala Pro Ala Asp Thr Pro Gly Leu Asn Gly Thr Cys Ser Val 
                485                 490                 495     


Ser Ser Val Pro Thr Ser Thr Ser Glu Thr Pro Asp Tyr Leu Leu Lys 
            500                 505                 510         


Tyr Ala Ala Ile Ser Ser Ser Glu Gln Arg Gln Ser Tyr Lys Asn Asp 
        515                 520                 525             


Phe Asn Ala Glu Tyr Ser Glu Tyr Arg Asp Leu His Ala Arg Ile Glu 
    530                 535                 540                 


Arg Ile Thr Arg Arg Phe Thr Gln Leu Asp Ala Gln Leu Arg Gln Leu 
545                 550                 555                 560 


Ser Gln Gly Ser Glu Glu Tyr Glu Thr Thr Arg Gly Gln Ile Leu Gln 
                565                 570                 575     


Glu Tyr Arg Lys Ile Lys Lys Thr Asn Thr Asn Tyr Ser Gln Glu Lys 
            580                 585                 590         


His Arg Cys Glu Tyr Leu His Ser Lys Leu Ala His Ile Lys Arg Leu 
        595                 600                 605             


Ile Ala Glu Tyr Asp Gln Arg Gln Leu Gln Ala Trp Pro 
    610                 615                 620     


<210>  3507
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELMO1__Homo_sapiens__NP_569709

<400>  3507

Met Gln Val Val Lys Glu Gln Val Met Arg Ala Leu Thr Thr Lys Pro 
1               5                   10                  15      


Ser Ser Leu Asp Gln Phe Lys Ser Lys Leu Gln Asn Leu Ser Tyr Thr 
            20                  25                  30          


Glu Ile Leu Lys Ile Arg Gln Ser Glu Arg Met Asn Gln Glu Asp Phe 
        35                  40                  45              


Gln Ser Arg Pro Ile Leu Glu Leu Lys Glu Lys Ile Gln Pro Glu Ile 
    50                  55                  60                  


Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Val Glu Gly Thr 
65                  70                  75                  80  


Cys Phe Arg Lys Leu Asn Ala Arg Arg Arg Gln Asp Lys Phe Trp Tyr 
                85                  90                  95      


Cys Arg Leu Ser Pro Asn His Lys Val Leu His Tyr Gly Asp Leu Glu 
            100                 105                 110         


Glu Ser Pro Gln Gly Glu Val Pro His Asp Ser Leu Gln Asp Lys Leu 
        115                 120                 125             


Pro Val Ala Asp Ile Lys Ala Val Val Thr Gly Lys Asp Cys Pro His 
    130                 135                 140                 


Met Lys Glu Lys Gly Ala Leu Lys Gln Asn Lys Glu Val Leu Glu Leu 
145                 150                 155                 160 


Ala Phe Ser Ile Leu Tyr Asp Ser Asn Cys Gln Leu Asn Phe Ile Ala 
                165                 170                 175     


Pro Asp Lys His Glu Tyr Cys Ile Trp Thr Asp Gly Leu Asn Ala Leu 
            180                 185                 190         


Leu Gly Lys Asp Met Met Ser Asp Leu Thr Arg Asn Asp Leu Asp Thr 
        195                 200                 205             


Leu Leu Ser Met Glu Ile Lys Leu Arg Leu Leu Asp Leu Glu Asn Ile 
    210                 215                 220                 


Gln Ile Pro Asp Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser Asn Tyr 
225                 230                 235                 240 


Asp Phe Val Tyr Asp Cys Asn 
                245         


<210>  3508
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELMO2__Homo_sapiens__NP_877496

<400>  3508

Met Pro Pro Pro Ser Asp Ile Val Lys Val Ala Ile Glu Trp Pro Gly 
1               5                   10                  15      


Ala Asn Ala Gln Leu Leu Glu Ile Asp Gln Lys Arg Pro Leu Ala Ser 
            20                  25                  30          


Ile Ile Lys Glu Val Cys Asp Gly Trp Ser Leu Pro Asn Pro Glu Tyr 
        35                  40                  45              


Tyr Thr Leu Arg Tyr Ala Asp Gly Pro Gln Leu Tyr Ile Thr Glu Gln 
    50                  55                  60                  


Thr Arg Ser Asp Ile Lys Asn Gly Thr Ile Leu Gln Leu Ala Ile Ser 
65                  70                  75                  80  


Pro Ser Arg Ala Ala Arg Gln Leu Met Glu Arg Thr Gln Ser Ser Asn 
                85                  90                  95      


Met Glu Thr Arg Leu Asp Ala Met Lys Glu Leu Ala Lys Leu Ser Ala 
            100                 105                 110         


Asp Val Thr Phe Ala Thr Glu Phe Ile Asn Met Asp Gly Ile Ile Val 
        115                 120                 125             


Leu Thr Arg Leu Val Glu Ser Gly Thr Lys Leu Leu Ser His Tyr Ser 
    130                 135                 140                 


Glu Met Leu Ala Phe Thr Leu Thr Ala Phe Leu Glu Leu Met Asp His 
145                 150                 155                 160 


Gly Ile Val Ser Trp Asp Met Val Ser Ile Thr Phe Ile Lys Gln Ile 
                165                 170                 175     


Ala Gly Tyr Val Ser Gln Pro Met Val Asp Val Ser Ile Leu Gln Arg 
            180                 185                 190         


Ser Leu Ala Ile Leu Glu Ser Met Val Leu Asn Ser Gln Ser Leu Tyr 
        195                 200                 205             


Gln Lys Ile Ala Glu Glu Ile Thr Val Gly Gln Leu Ile Ser His Leu 
    210                 215                 220                 


Gln Val Ser Asn Gln Glu Ile Gln Thr Tyr Ala Ile Ala Leu Ile Asn 
225                 230                 235                 240 


Ala Leu Phe Leu Lys Ala Pro Glu Asp Lys Arg Gln Asp Met Ala Asn 
                245                 250                 255     


Ala Phe Ala Gln Lys His Leu Arg Ser Ile Ile Leu Asn His Val Ile 
            260                 265                 270         


Arg Gly Asn Arg Pro Ile Lys Thr Glu Met Ala His Gln Leu Tyr Val 
        275                 280                 285             


Leu Gln Val Leu Thr Phe Asn Leu Leu Glu Glu Arg Met Met Thr Lys 
    290                 295                 300                 


Met Asp Pro Asn Asp Gln Ala Gln Arg Asp Ile Ile Phe Glu Leu Arg 
305                 310                 315                 320 


Arg Ile Ala Phe Asp Ala Glu Ser Asp Pro Ser Asn Ala Pro Gly Ser 
                325                 330                 335     


Gly Thr Glu Lys Arg Lys Ala Met Tyr Thr Lys Asp Tyr Lys Met Leu 
            340                 345                 350         


Gly Phe Thr Asn His Ile Asn Pro Ala Met Asp Phe Thr Gln Thr Pro 
        355                 360                 365             


Pro Gly Met Leu Ala Leu Asp Asn Met Leu Tyr Leu Ala Lys Val His 
    370                 375                 380                 


Gln Asp Thr Tyr Ile Arg Ile Val Leu Glu Asn Ser Ser Arg Glu Asp 
385                 390                 395                 400 


Lys His Glu Cys Pro Phe Gly Arg Ser Ala Ile Glu Leu Thr Lys Met 
                405                 410                 415     


Leu Cys Glu Ile Leu Gln Val Gly Glu Leu Pro Asn Glu Gly Arg Asn 
            420                 425                 430         


Asp Tyr His Pro Met Phe Phe Thr His Asp Arg Ala Phe Glu Glu Leu 
        435                 440                 445             


Phe Gly Ile Cys Ile Gln Leu Leu Asn Lys Thr Trp Lys Glu Met Arg 
    450                 455                 460                 


Ala Thr Ala Glu Asp Phe Asn Lys Val Met Gln Val Val Arg Glu Gln 
465                 470                 475                 480 


Ile Thr Arg Ala Leu Pro Ser Lys Pro Asn Ser Leu Asp Gln Phe Lys 
                485                 490                 495     


Ser Lys Leu Arg Ser Leu Ser Tyr Ser Glu Ile Leu Arg Leu Arg Gln 
            500                 505                 510         


Ser Glu Arg Met Ser Gln Asp Asp Phe Gln Ser Pro Pro Ile Val Glu 
        515                 520                 525             


Leu Arg Glu Lys Ile Gln Pro Glu Ile Leu Glu Leu Ile Lys Gln Gln 
    530                 535                 540                 


Arg Leu Asn Arg Leu Cys Glu Gly Ser Ser Phe Arg Lys Ile Gly Asn 
545                 550                 555                 560 


Arg Arg Arg Gln Glu Arg Phe Trp Tyr Cys Arg Leu Ala Leu Asn His 
                565                 570                 575     


Lys Val Leu His Tyr Gly Asp Leu Asp Asp Asn Pro Gln Gly Glu Val 
            580                 585                 590         


Thr Phe Glu Ser Leu Gln Glu Lys Ile Pro Val Ala Asp Ile Lys Ala 
        595                 600                 605             


Ile Val Thr Gly Lys Asp Cys Pro His Met Lys Glu Lys Ser Ala Leu 
    610                 615                 620                 


Lys Gln Asn Lys Glu Val Leu Glu Leu Ala Phe Ser Ile Leu Tyr Asp 
625                 630                 635                 640 


Pro Asp Glu Thr Leu Asn Phe Ile Ala Pro Asn Lys Tyr Glu Tyr Cys 
                645                 650                 655     


Ile Trp Ile Asp Gly Leu Ser Ala Leu Leu Gly Lys Asp Met Ser Ser 
            660                 665                 670         


Glu Leu Thr Lys Ser Asp Leu Asp Thr Leu Leu Ser Met Glu Met Lys 
        675                 680                 685             


Leu Arg Leu Leu Asp Leu Glu Asn Ile Gln Ile Pro Glu Ala Pro Pro 
    690                 695                 700                 


Pro Ile Pro Lys Glu Pro Ser Ser Tyr Asp Phe Val Tyr His Tyr Gly 
705                 710                 715                 720 


<210>  3509
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELMOD1__Homo_sapiens__NP_001123509

<400>  3509

Met Lys His Phe Leu Arg Met Leu Ile Gln Val Cys Leu Tyr Phe Tyr 
1               5                   10                  15      


Cys Lys Phe Leu Trp Arg Cys Leu Lys Phe Val Met Arg Lys Leu Thr 
            20                  25                  30          


Gly Arg Cys Glu Leu Gln Arg Ile Cys Tyr Asn Thr Lys Pro Gly Ala 
        35                  40                  45              


Ser Arg Thr Met Lys Ile Glu Thr Ser Leu Arg Asp Ser Lys Ser Lys 
    50                  55                  60                  


Leu Leu Gln Thr Ser Val Ser Val His Pro Asp Ala Ile Glu Lys Thr 
65                  70                  75                  80  


Ile Glu Asp Ile Met Glu Leu Lys Lys Ile Asn Pro Asp Val Asn Pro 
                85                  90                  95      


Gln Leu Gly Ile Ser Leu Gln Ala Cys Leu Leu Gln Ile Val Gly Tyr 
            100                 105                 110         


Arg Asn Leu Ile Ala Asp Val Glu Lys Leu Arg Arg Glu Ala Tyr Asp 
        115                 120                 125             


Ser Asp Asn Pro Gln His Glu Glu Met Leu Leu Lys Leu Trp Lys Phe 
    130                 135                 140                 


Leu Lys Pro Asn Thr Pro Leu Glu Ser Arg Ile Ser Lys Gln Trp Cys 
145                 150                 155                 160 


Glu Ile Gly Phe Gln Gly Asp Asp Pro Lys Thr Asp Phe Arg Gly Met 
                165                 170                 175     


Gly Leu Leu Gly Leu Tyr Asn Leu Gln Tyr Phe Ala Glu Arg Asp Ala 
            180                 185                 190         


Thr Ala Ala Gln Gln Val Leu Ser Asp Ser Leu His Pro Lys Cys Ser 
        195                 200                 205             


Lys Phe Ser Lys Ala Glu Trp Glu Lys Lys Arg Met Asp Lys Ala Ile 
    210                 215                 220                 


Gly Tyr Ser Phe Ala Ile Val Gly Ile Asn Ile Thr Asp Leu Ala Tyr 
225                 230                 235                 240 


Asn Leu Leu Val Ser Gly Ala Leu Lys Thr His Phe Tyr Asn Ile Ala 
                245                 250                 255     


Pro Glu Ala Pro Thr Leu Ser His Phe Gln Gln Thr Phe Cys Tyr Leu 
            260                 265                 270         


Met His Glu Phe His Lys Phe Trp Ile Glu Glu Asp Pro Met Asp Ile 
        275                 280                 285             


Met Glu Phe Asn Arg Val Arg Glu Lys Phe Arg Lys Arg Ile Ile Lys 
    290                 295                 300                 


Gln Leu Gln Asn Pro Asp Met Ala Leu Cys Pro His Phe Ala Ala Ser 
305                 310                 315                 320 


Glu Gly Leu Ile Asn Met 
                325     


<210>  3510
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELMOD2__Homo_sapiens__NP_714913

<400>  3510

Met Phe Ile Ser Leu Trp Glu Phe Phe Tyr Gly His Phe Phe Arg Phe 
1               5                   10                  15      


Trp Met Lys Trp Leu Leu Arg Gln Met Thr Gly Lys Cys Glu Leu Gln 
            20                  25                  30          


Arg Ile Phe Asp Thr Tyr Val Gly Ala Gln Arg Thr His Arg Ile Glu 
        35                  40                  45              


Asn Ser Leu Thr Tyr Ser Lys Asn Lys Val Leu Gln Lys Ala Thr His 
    50                  55                  60                  


Val Val Gln Ser Glu Val Asp Lys Tyr Val Asp Asp Ile Met Lys Glu 
65                  70                  75                  80  


Lys Asn Ile Asn Pro Glu Lys Asp Ala Ser Phe Lys Ile Cys Met Lys 
                85                  90                  95      


Met Cys Leu Leu Gln Ile Thr Gly Tyr Lys Gln Leu Tyr Leu Asp Val 
            100                 105                 110         


Glu Ser Val Arg Lys Arg Pro Tyr Asp Ser Asp Asn Leu Gln His Glu 
        115                 120                 125             


Glu Leu Leu Met Lys Leu Trp Asn Leu Leu Met Pro Thr Lys Lys Leu 
    130                 135                 140                 


Asn Ala Arg Ile Ser Lys Gln Trp Ala Glu Ile Gly Phe Gln Gly Asp 
145                 150                 155                 160 


Asp Pro Lys Thr Asp Phe Arg Gly Met Gly Ile Leu Gly Leu Ile Asn 
                165                 170                 175     


Leu Val Tyr Phe Ser Glu Asn Tyr Thr Ser Glu Ala His Gln Ile Leu 
            180                 185                 190         


Ser Arg Ser Asn His Pro Lys Leu Gly Tyr Ser Tyr Ala Ile Val Gly 
        195                 200                 205             


Ile Asn Leu Thr Glu Met Ala Tyr Ser Leu Leu Lys Ser Glu Ala Leu 
    210                 215                 220                 


Lys Phe His Leu Tyr Asn Leu Val Pro Gly Ile Pro Thr Met Glu His 
225                 230                 235                 240 


Phe His Gln Phe Tyr Cys Tyr Leu Val Tyr Glu Phe Asp Lys Phe Trp 
                245                 250                 255     


Phe Glu Glu Glu Pro Glu Ser Ile Met Tyr Phe Asn Leu Tyr Arg Glu 
            260                 265                 270         


Lys Phe His Glu Lys Ile Lys Gly Leu Leu Leu Asp Cys Asn Val Ala 
        275                 280                 285             


Leu Thr Leu Lys Val 
    290             


<210>  3511
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELMOD3__Homo_sapiens__NP_001128494

<400>  3511

Met Asn Glu Lys Ser Cys Ser Phe His Ser Lys Glu Glu Leu Arg Asp 
1               5                   10                  15      


Gly Gln Gly Glu Arg Leu Ser Ala Gly Tyr Ser Pro Ser Tyr Asp Lys 
            20                  25                  30          


Asp Lys Ser Val Leu Ala Phe Arg Gly Ile Pro Ile Ser Glu Leu Lys 
        35                  40                  45              


Asn His Gly Ile Leu Gln Ala Leu Thr Thr Glu Ala Tyr Glu Trp Glu 
    50                  55                  60                  


Pro Arg Val Val Ser Thr Glu Val Val Arg Ala Gln Glu Glu Trp Glu 
65                  70                  75                  80  


Ala Val Asp Thr Ile Gln Pro Glu Thr Gly Ser Gln Ala Ser Ser Glu 
                85                  90                  95      


Gln Pro Gly Gln Leu Ile Ser Phe Ser Glu Ala Leu Gln His Phe Gln 
            100                 105                 110         


Thr Val Asp Leu Ser Pro Phe Lys Lys Arg Ile Gln Pro Thr Ile Arg 
        115                 120                 125             


Arg Thr Gly Leu Ala Ala Leu Arg His Tyr Leu Phe Gly Pro Pro Lys 
    130                 135                 140                 


Leu His Gln Arg Leu Arg Glu Glu Arg Asp Leu Val Leu Thr Ile Ala 
145                 150                 155                 160 


Gln Cys Gly Leu Asp Ser Gln Asp Pro Val His Gly Arg Val Leu Gln 
                165                 170                 175     


Thr Ile Tyr Lys Lys Leu Thr Gly Ser Lys Phe Asp Cys Ala Leu His 
            180                 185                 190         


Gly Asn His Trp Glu Asp Leu Gly Phe Gln Gly Ala Asn Pro Ala Thr 
        195                 200                 205             


Asp Leu Arg Gly Ala Gly Phe Leu Ala Leu Leu His Leu Leu Tyr Leu 
    210                 215                 220                 


Val Met Asp Ser Lys Thr Leu Pro Met Ala Gln Glu Ile Phe Arg Leu 
225                 230                 235                 240 


Ser Arg His His Ile Gln Gln Phe Pro Phe Cys Leu Met Ser Val Asn 
                245                 250                 255     


Ile Thr His Ile Ala Ile Gln Ala Leu Arg Glu Glu Cys Leu Ser Arg 
            260                 265                 270         


Glu Cys Asn Arg Gln Gln Lys Val Ile Pro Val Val Asn Ser Phe Tyr 
        275                 280                 285             


Ala Ala Thr Phe Leu His Leu Ala His Val Trp Arg Thr Gln Arg Lys 
    290                 295                 300                 


Thr Ile Ser Asp Ser Gly Phe Val Leu Lys Glu Leu Glu Val Leu Ala 
305                 310                 315                 320 


Lys Lys Ser Pro Arg Arg Leu Leu Lys Thr Leu Glu Leu Tyr Leu Ala 
                325                 330                 335     


Arg Val Ser Lys Gly Gln Ala Ser Leu Leu Gly Ala Gln Lys Cys Tyr 
            340                 345                 350         


Gly Pro Glu Ala Pro Pro Phe Lys Asp Leu Thr Phe Thr Gly Glu Ser 
        355                 360                 365             


Asp Leu Gln Ser His Ser Ser Glu Gly Val Trp Leu Ile 
    370                 375                 380     


<210>  3512
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELMSAN1__Homo_sapiens__NP_919254

<400>  3512

Met Asn Leu Gln Ala Gln Pro Lys Ala Gln Asn Lys Arg Lys Arg Cys 
1               5                   10                  15      


Leu Phe Gly Gly Gln Glu Pro Ala Pro Lys Glu Gln Pro Pro Pro Leu 
            20                  25                  30          


Gln Pro Pro Gln Gln Ser Ile Arg Val Lys Glu Glu Gln Tyr Leu Gly 
        35                  40                  45              


His Glu Gly Pro Gly Gly Ala Val Ser Thr Ser Gln Pro Val Glu Leu 
    50                  55                  60                  


Pro Pro Pro Ser Ser Leu Ala Leu Leu Asn Ser Val Val Tyr Gly Pro 
65                  70                  75                  80  


Glu Arg Thr Ser Ala Ala Met Leu Ser Gln Gln Val Ala Ser Val Lys 
                85                  90                  95      


Trp Pro Asn Ser Val Met Ala Pro Gly Arg Gly Pro Glu Arg Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ser Asp Ser Ser Trp Gln Gln Gln Pro Gly Gln Pro 
        115                 120                 125             


Pro Pro His Ser Thr Trp Asn Cys His Ser Leu Ser Leu Tyr Ser Ala 
    130                 135                 140                 


Thr Lys Gly Ser Pro His Pro Gly Val Gly Val Pro Thr Tyr Tyr Asn 
145                 150                 155                 160 


His Pro Glu Ala Leu Lys Arg Glu Lys Ala Gly Gly Pro Gln Leu Asp 
                165                 170                 175     


Arg Tyr Val Arg Pro Met Met Pro Gln Lys Val Gln Leu Glu Val Gly 
            180                 185                 190         


Arg Pro Gln Ala Pro Leu Asn Ser Phe His Ala Ala Lys Lys Pro Pro 
        195                 200                 205             


Asn Gln Ser Leu Pro Leu Gln Pro Phe Gln Leu Ala Phe Gly His Gln 
    210                 215                 220                 


Val Asn Arg Gln Val Phe Arg Gln Gly Pro Pro Pro Pro Asn Pro Val 
225                 230                 235                 240 


Ala Ala Phe Pro Pro Gln Lys Gln Gln Gln Gln Gln Gln Pro Gln Gln 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Ala Ala Leu Pro Gln Met Pro Leu Phe Glu 
            260                 265                 270         


Asn Phe Tyr Ser Met Pro Gln Gln Pro Ser Gln Gln Pro Gln Asp Phe 
        275                 280                 285             


Gly Leu Gln Pro Ala Gly Pro Leu Gly Gln Ser His Leu Ala His His 
    290                 295                 300                 


Ser Met Ala Pro Tyr Pro Phe Pro Pro Asn Pro Asp Met Asn Pro Glu 
305                 310                 315                 320 


Leu Arg Lys Ala Leu Leu Gln Asp Ser Ala Pro Gln Pro Ala Leu Pro 
                325                 330                 335     


Gln Val Gln Ile Pro Phe Pro Arg Arg Ser Arg Arg Leu Ser Lys Glu 
            340                 345                 350         


Gly Ile Leu Pro Pro Ser Ala Leu Asp Gly Ala Gly Thr Gln Pro Gly 
        355                 360                 365             


Gln Glu Ala Thr Gly Asn Leu Phe Leu His His Trp Pro Leu Gln Gln 
    370                 375                 380                 


Pro Pro Pro Gly Ser Leu Gly Gln Pro His Pro Glu Ala Leu Gly Phe 
385                 390                 395                 400 


Pro Leu Glu Leu Arg Glu Ser Gln Leu Leu Pro Asp Gly Glu Arg Leu 
                405                 410                 415     


Ala Pro Asn Gly Arg Glu Arg Glu Ala Pro Ala Met Gly Ser Glu Glu 
            420                 425                 430         


Gly Met Arg Ala Val Ser Thr Gly Asp Cys Gly Gln Val Leu Arg Gly 
        435                 440                 445             


Gly Val Ile Gln Ser Thr Arg Arg Arg Arg Arg Ala Ser Gln Glu Ala 
    450                 455                 460                 


Asn Leu Leu Thr Leu Ala Gln Lys Ala Val Glu Leu Ala Ser Leu Gln 
465                 470                 475                 480 


Asn Ala Lys Asp Gly Ser Gly Ser Glu Glu Lys Arg Lys Ser Val Leu 
                485                 490                 495     


Ala Ser Thr Thr Lys Cys Gly Val Glu Phe Ser Glu Pro Ser Leu Ala 
            500                 505                 510         


Thr Lys Arg Ala Arg Glu Asp Ser Gly Met Val Pro Leu Ile Ile Pro 
        515                 520                 525             


Val Ser Val Pro Val Arg Thr Val Asp Pro Thr Glu Ala Ala Gln Ala 
    530                 535                 540                 


Gly Gly Leu Asp Glu Asp Gly Lys Gly Pro Glu Gln Asn Pro Ala Glu 
545                 550                 555                 560 


His Lys Pro Ser Val Ile Val Thr Arg Arg Arg Ser Thr Arg Ile Pro 
                565                 570                 575     


Gly Thr Asp Ala Gln Ala Gln Ala Glu Asp Met Asn Val Lys Leu Glu 
            580                 585                 590         


Gly Glu Pro Ser Val Arg Lys Pro Lys Gln Arg Pro Arg Pro Glu Pro 
        595                 600                 605             


Leu Ile Ile Pro Thr Lys Ala Gly Thr Phe Ile Ala Pro Pro Val Tyr 
    610                 615                 620                 


Ser Asn Ile Thr Pro Tyr Gln Ser His Leu Arg Ser Pro Val Arg Leu 
625                 630                 635                 640 


Ala Asp His Pro Ser Glu Arg Ser Phe Glu Leu Pro Pro Tyr Thr Pro 
                645                 650                 655     


Pro Pro Ile Leu Ser Pro Val Arg Glu Gly Ser Gly Leu Tyr Phe Asn 
            660                 665                 670         


Ala Ile Ile Ser Thr Ser Thr Ile Pro Ala Pro Pro Pro Ile Thr Pro 
        675                 680                 685             


Lys Ser Ala His Arg Thr Leu Leu Arg Thr Asn Ser Ala Glu Val Thr 
    690                 695                 700                 


Pro Pro Val Leu Ser Val Met Gly Glu Ala Thr Pro Val Ser Ile Glu 
705                 710                 715                 720 


Pro Arg Ile Asn Val Gly Ser Arg Phe Gln Ala Glu Ile Pro Leu Met 
                725                 730                 735     


Arg Asp Arg Ala Leu Ala Ala Ala Asp Pro His Lys Ala Asp Leu Val 
            740                 745                 750         


Trp Gln Pro Trp Glu Asp Leu Glu Ser Ser Arg Glu Lys Gln Arg Gln 
        755                 760                 765             


Val Glu Asp Leu Leu Thr Ala Ala Cys Ser Ser Ile Phe Pro Gly Ala 
    770                 775                 780                 


Gly Thr Asn Gln Glu Leu Ala Leu His Cys Leu His Glu Ser Arg Gly 
785                 790                 795                 800 


Asp Ile Leu Glu Thr Leu Asn Lys Leu Leu Leu Lys Lys Pro Leu Arg 
                805                 810                 815     


Pro His Asn His Pro Leu Ala Thr Tyr His Tyr Thr Gly Ser Asp Gln 
            820                 825                 830         


Trp Lys Met Ala Glu Arg Lys Leu Phe Asn Lys Gly Ile Ala Ile Tyr 
        835                 840                 845             


Lys Lys Asp Phe Phe Leu Val Gln Lys Leu Ile Gln Thr Lys Thr Val 
    850                 855                 860                 


Ala Gln Cys Val Glu Phe Tyr Tyr Thr Tyr Lys Lys Gln Val Lys Ile 
865                 870                 875                 880 


Gly Arg Asn Gly Thr Leu Thr Phe Gly Asp Val Asp Thr Ser Asp Glu 
                885                 890                 895     


Lys Ser Ala Gln Glu Glu Val Glu Val Asp Ile Lys Thr Ser Gln Lys 
            900                 905                 910         


Phe Pro Arg Val Pro Leu Pro Arg Arg Glu Ser Pro Ser Glu Glu Arg 
        915                 920                 925             


Leu Glu Pro Lys Arg Glu Val Lys Glu Pro Arg Lys Glu Gly Glu Glu 
    930                 935                 940                 


Glu Val Pro Glu Ile Gln Glu Lys Glu Glu Gln Glu Glu Gly Arg Glu 
945                 950                 955                 960 


Arg Ser Arg Arg Ala Ala Ala Val Lys Ala Thr Gln Thr Leu Gln Ala 
                965                 970                 975     


Asn Glu Ser Ala Ser Asp Ile Leu Ile Leu Arg Ser His Glu Ser Asn 
            980                 985                 990         


Ala Pro Gly Ser Ala Gly Gly Gln  Ala Ser Glu Lys Pro  Arg Glu Gly 
        995                 1000                 1005             


Thr Gly  Lys Ser Arg Arg Ala  Leu Pro Phe Ser Glu  Lys Lys Lys 
    1010                 1015                 1020             


Lys Thr  Glu Thr Phe Ser Lys  Thr Gln Asn Gln Glu  Asn Thr Phe 
    1025                 1030                 1035             


Pro Cys  Lys Lys Cys Gly Arg  
    1040                 1045 


<210>  3513
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELN__Homo_sapiens__NP_000492

<400>  3513

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540                 


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
            580                 585                 590         


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
        595                 600                 605             


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
    610                 615                 620                 


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
625                 630                 635                 640 


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
                645                 650                 655     


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
            660                 665                 670         


Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly 
        675                 680                 685             


Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly 
    690                 695                 700                 


Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly 
705                 710                 715                 720 


Arg Lys Arg Lys 
                


<210>  3514
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELOF1__Homo_sapiens__NP_115753

<400>  3514

Met Gly Arg Arg Lys Ser Lys Arg Lys Pro Pro Pro Lys Lys Lys Met 
1               5                   10                  15      


Thr Gly Thr Leu Glu Thr Gln Phe Thr Cys Pro Phe Cys Asn His Glu 
            20                  25                  30          


Lys Ser Cys Asp Val Lys Met Asp Arg Ala Arg Asn Thr Gly Val Ile 
        35                  40                  45              


Ser Cys Thr Val Cys Leu Glu Glu Phe Gln Thr Pro Ile Thr Tyr Leu 
    50                  55                  60                  


Ser Glu Pro Val Asp Val Tyr Ser Asp Trp Ile Asp Ala Cys Glu Ala 
65                  70                  75                  80  


Ala Asn Gln 
            


<210>  3515
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELOVL2__Homo_sapiens__NP_060240

<400>  3515

Met Glu His Leu Lys Ala Phe Asp Asp Glu Ile Asn Ala Phe Leu Asp 
1               5                   10                  15      


Asn Met Phe Gly Pro Arg Asp Ser Arg Val Arg Gly Trp Phe Met Leu 
            20                  25                  30          


Asp Ser Tyr Leu Pro Thr Phe Phe Leu Thr Val Met Tyr Leu Leu Ser 
        35                  40                  45              


Ile Trp Leu Gly Asn Lys Tyr Met Lys Asn Arg Pro Ala Leu Ser Leu 
    50                  55                  60                  


Arg Gly Ile Leu Thr Leu Tyr Asn Leu Gly Ile Thr Leu Leu Ser Ala 
65                  70                  75                  80  


Tyr Met Leu Ala Glu Leu Ile Leu Ser Thr Trp Glu Gly Gly Tyr Asn 
                85                  90                  95      


Leu Gln Cys Gln Asp Leu Thr Ser Ala Gly Glu Ala Asp Ile Arg Val 
            100                 105                 110         


Ala Lys Val Leu Trp Trp Tyr Tyr Phe Ser Lys Ser Val Glu Phe Leu 
        115                 120                 125             


Asp Thr Ile Phe Phe Val Leu Arg Lys Lys Thr Ser Gln Ile Thr Phe 
    130                 135                 140                 


Leu His Val Tyr His His Ala Ser Met Phe Asn Ile Trp Trp Cys Val 
145                 150                 155                 160 


Leu Asn Trp Ile Pro Cys Gly Gln Ser Phe Phe Gly Pro Thr Leu Asn 
                165                 170                 175     


Ser Phe Ile His Ile Leu Met Tyr Ser Tyr Tyr Gly Leu Ser Val Phe 
            180                 185                 190         


Pro Ser Met His Lys Tyr Leu Trp Trp Lys Lys Tyr Leu Thr Gln Ala 
        195                 200                 205             


Gln Leu Val Gln Phe Val Leu Thr Ile Thr His Thr Met Ser Ala Val 
    210                 215                 220                 


Val Lys Pro Cys Gly Phe Pro Phe Gly Cys Leu Ile Phe Gln Ser Ser 
225                 230                 235                 240 


Tyr Met Leu Thr Leu Val Ile Leu Phe Leu Asn Phe Tyr Val Gln Thr 
                245                 250                 255     


Tyr Arg Lys Lys Pro Met Lys Lys Asp Met Gln Glu Pro Pro Ala Gly 
            260                 265                 270         


Lys Glu Val Lys Asn Gly Phe Ser Lys Ala Tyr Phe Thr Ala Ala Asn 
        275                 280                 285             


Gly Val Met Asn Lys Lys Ala Gln 
    290                 295     


<210>  3516
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELOVL4__Homo_sapiens__NP_073563

<400>  3516

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Leu Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Leu Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Thr Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Ile 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Ile Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Pro Lys Ala Gly Lys Thr Ala Met Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Met Ile Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Asp 
305                 310                 


<210>  3517
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELOVL5__Homo_sapiens__NP_001229757

<400>  3517

Met Glu His Phe Asp Ala Ser Leu Ser Thr Tyr Phe Lys Ala Leu Leu 
1               5                   10                  15      


Gly Pro Arg Asp Thr Arg Val Lys Gly Trp Phe Leu Leu Asp Asn Tyr 
            20                  25                  30          


Ile Pro Thr Phe Ile Cys Ser Val Ile Tyr Leu Leu Ile Val Trp Leu 
        35                  40                  45              


Gly Pro Lys Tyr Met Arg Asn Lys Gln Pro Phe Ser Cys Arg Gly Ile 
    50                  55                  60                  


Leu Val Val Tyr Asn Leu Gly Leu Thr Leu Leu Ser Leu Tyr Met Phe 
65                  70                  75                  80  


Cys Glu Ser Lys Arg Glu Gln Pro Arg Arg Ser Ala Cys Ala Ser Arg 
                85                  90                  95      


Thr Asp Pro Ser Thr Gln Gln Gln Leu Pro Glu Asn Arg Leu Val Thr 
            100                 105                 110         


Gly Val Trp Glu Gly Lys Tyr Asn Phe Phe Cys Gln Gly Thr Arg Thr 
        115                 120                 125             


Ala Gly Glu Ser Asp Met Lys Ile Ile Arg Val Leu Trp Trp Tyr Tyr 
    130                 135                 140                 


Phe Ser Lys Leu Ile Glu Phe Met Asp Thr Phe Phe Phe Ile Leu Arg 
145                 150                 155                 160 


Lys Asn Asn His Gln Ile Thr Val Leu His Val Tyr His His Ala Ser 
                165                 170                 175     


Met Leu Asn Ile Trp Trp Phe Val Met Asn Trp Val Pro Cys Gly His 
            180                 185                 190         


Ser Tyr Phe Gly Ala Thr Leu Asn Ser Phe Ile His Val Leu Met Tyr 
        195                 200                 205             


Ser Tyr Tyr Gly Leu Ser Ser Val Pro Ser Met Arg Pro Tyr Leu Trp 
    210                 215                 220                 


Trp Lys Lys Tyr Ile Thr Gln Gly Gln Leu Leu Gln Phe Val Leu Thr 
225                 230                 235                 240 


Ile Ile Gln Thr Ser Cys Gly Val Ile Trp Pro Cys Thr Phe Pro Leu 
                245                 250                 255     


Gly Trp Leu Tyr Phe Gln Ile Gly Tyr Met Ile Ser Leu Ile Ala Leu 
            260                 265                 270         


Phe Thr Asn Phe Tyr Ile Gln Thr Tyr Asn Lys Lys Gly Ala Ser Arg 
        275                 280                 285             


Arg Lys Asp His Leu Lys Asp His Gln Asn Gly Ser Met Ala Ala Val 
    290                 295                 300                 


Asn Gly His Thr Asn Ser Phe Ser Pro Leu Glu Asn Asn Val Lys Pro 
305                 310                 315                 320 


Arg Lys Leu Arg Lys Asp 
                325     


<210>  3518
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELOVL6__Homo_sapiens__XP_011530536

<400>  3518

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15      


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30          


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45              


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60                  


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80  


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95      


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110         


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125             


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140                 


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160 


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175     


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190         


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205             


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220                 


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240 


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255     


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265 


<210>  3519
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELOVL7__Homo_sapiens__NP_001098028

<400>  3519

Met Ala Phe Ser Asp Leu Thr Ser Arg Thr Val His Leu Tyr Asp Asn 
1               5                   10                  15      


Trp Ile Lys Asp Ala Asp Pro Arg Val Glu Asp Trp Leu Leu Met Ser 
            20                  25                  30          


Ser Pro Leu Pro Gln Thr Ile Leu Leu Gly Phe Tyr Val Tyr Phe Val 
        35                  40                  45              


Thr Ser Leu Gly Pro Lys Leu Met Glu Asn Arg Lys Pro Phe Glu Leu 
    50                  55                  60                  


Lys Lys Ala Met Ile Thr Tyr Asn Phe Phe Ile Val Leu Phe Ser Val 
65                  70                  75                  80  


Tyr Met Cys Tyr Glu Phe Val Met Ser Gly Trp Gly Ile Gly Tyr Ser 
                85                  90                  95      


Phe Arg Cys Asp Ile Val Asp Tyr Ser Arg Ser Pro Thr Ala Leu Arg 
            100                 105                 110         


Met Ala Arg Thr Cys Trp Leu Tyr Tyr Phe Ser Lys Phe Ile Glu Leu 
        115                 120                 125             


Leu Asp Thr Ile Phe Phe Val Leu Arg Lys Lys Asn Ser Gln Val Thr 
    130                 135                 140                 


Phe Leu His Val Phe His His Thr Ile Met Pro Trp Thr Trp Trp Phe 
145                 150                 155                 160 


Gly Val Lys Phe Ala Ala Gly Gly Leu Gly Thr Phe His Ala Leu Leu 
                165                 170                 175     


Asn Thr Ala Val His Val Val Met Tyr Ser Tyr Tyr Gly Leu Ser Ala 
            180                 185                 190         


Leu Gly Pro Ala Tyr Gln Lys Tyr Leu Trp Trp Lys Lys Tyr Leu Thr 
        195                 200                 205             


Ser Leu Gln Leu Val Gln Phe Val Ile Val Ala Ile His Ile Ser Gln 
    210                 215                 220                 


Phe Phe Phe Met Glu Asp Cys Lys Tyr Gln Phe Pro Val Phe Ala Cys 
225                 230                 235                 240 


Ile Ile Met Ser Tyr Ser Phe Met Phe Leu Leu Leu Phe Leu His Phe 
                245                 250                 255     


Trp Tyr Arg Ala Tyr Thr Lys Gly Gln Arg Leu Pro Lys Thr Val Lys 
            260                 265                 270         


Asn Gly Thr Cys Lys Asn Lys Asp Asn 
        275                 280     


<210>  3520
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP2__Homo_sapiens__NP_001229804

<400>  3520

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly 
145                 150                 155                 160 


Phe Ala Leu Ala Leu Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Thr 
                165                 170                 175     


Trp Lys Thr Gly Gln Val Glu Arg Gly Arg Ala Trp Lys Pro Pro Ala 
            180                 185                 190         


Ser Leu Ala Leu Cys Ser Arg Ser Cys Asp Ser Met Val Ser Cys Tyr 
        195                 200                 205             


Ala Ser Ile Leu Cys Lys Ala Leu Trp Lys Glu Lys Leu His Thr Phe 
    210                 215                 220                 


Trp His His Asn Arg Ile Ser Phe Leu Pro Ser Ala Phe Arg Pro Ile 
225                 230                 235                 240 


Pro Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg Ile His Ile Phe Ala 
                245                 250                 255     


Gln Gln Asn Asp Gln Phe Gln Lys Val Leu Ser Leu Cys Gly His Glu 
            260                 265                 270         


Asp Trp Ile Arg Gly Val Glu Trp Ala Ala Phe Gly Arg Asp Leu Phe 
        275                 280                 285             


Leu Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg Ile Trp Lys Leu Tyr 
    290                 295                 300                 


Ile Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp Asp Asn Ile Arg Leu 
305                 310                 315                 320 


Lys Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser Val Lys Ile Ala Phe 
                325                 330                 335     


Ala Val Thr Leu Glu Thr Val Leu Ala Gly His Glu Asn Trp Val Asn 
            340                 345                 350         


Ala Val His Trp Gln Pro Val Phe Tyr Lys Asp Gly Val Leu Gln Gln 
        355                 360                 365             


Pro Val Arg Leu Leu Ser Ala Ser Met Asp Lys Thr Met Ile Leu Trp 
    370                 375                 380                 


Ala Pro Asp Glu Glu Ser Gly Val Trp Leu Glu Gln Val Arg Val Gly 
385                 390                 395                 400 


Glu Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp Cys Gln Phe Asn Glu 
                405                 410                 415     


Asp Gly Ser Met Ile Ile Ala His Ala Phe His Gly Ala Leu His Leu 
            420                 425                 430         


Trp Lys Gln Asn Thr Val Asn Pro Arg Glu Trp Thr Pro Glu Ile Val 
        435                 440                 445             


Ile Ser Gly His Phe Asp Gly Val Gln Asp Leu Val Trp Asp Pro Glu 
    450                 455                 460                 


Gly Glu Phe Ile Ile Thr Val Gly Thr Asp Gln Thr Thr Arg Leu Phe 
465                 470                 475                 480 


Ala Pro Trp Lys Arg Lys Asp Gln Ser Gln Val Thr Trp His Glu Ile 
                485                 490                 495     


Ala Arg Pro Gln Ile His Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile 
            500                 505                 510         


Asn Arg Phe Gln Phe Val Ser Gly Ala Asp Glu Lys Val Leu Arg Val 
        515                 520                 525             


Phe Ser Ala Pro Arg Asn Phe Val Glu Asn Phe Cys Ala Ile Thr Gly 
    530                 535                 540                 


Gln Ser Leu Asn His Val Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu 
545                 550                 555                 560 


Gly Ala Thr Val Pro Ala Leu Gly Leu Ser Asn Lys Ala Val Phe Gln 
                565                 570                 575     


Gly Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser 
            580                 585                 590         


Thr Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln Pro Ser Ile Leu Thr 
        595                 600                 605             


Glu Pro Pro Thr Glu Asp His Leu Leu Gln Asn Thr Leu Trp Pro Glu 
    610                 615                 620                 


Val Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile Phe Cys Val Thr Cys 
625                 630                 635                 640 


Asn Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys 
                645                 650                 655     


Glu His Ala Ala Ile Ile Leu Trp Asn Thr Thr Ser Trp Lys Gln Val 
            660                 665                 670         


Gln Asn Leu Val Phe His Ser Leu Thr Val Thr Gln Met Ala Phe Ser 
        675                 680                 685             


Pro Asn Glu Lys Phe Leu Leu Ala Val Ser Arg Asp Arg Thr Trp Ser 
    690                 695                 700                 


Leu Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu Phe Glu Pro Val Phe 
705                 710                 715                 720 


Ser Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser Val His Ser Arg Ile 
                725                 730                 735     


Ile Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly 
            740                 745                 750         


Ser Arg Asp Lys Lys Val Val Val Trp Gly Glu Cys Asp Ser Thr Asp 
        755                 760                 765             


Asp Cys Ile Glu His Asn Ile Gly Pro Cys Ser Ser Val Leu Asp Val 
    770                 775                 780                 


Gly Gly Ala Val Thr Ala Val Ser Val Cys Pro Val Leu His Pro Ser 
785                 790                 795                 800 


Gln Arg Tyr Val Val Ala Val Gly Leu Glu Cys Gly Lys Ile Cys Leu 
                805                 810                 815     


Tyr Thr Trp Lys Lys Thr Asp Gln Val Pro Glu Ile Asn Asp Trp Thr 
            820                 825                 830         


His Cys Val Glu Thr Ser Gln Ser Gln Ser His Thr Leu Ala Ile Arg 
        835                 840                 845             


Lys Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala 
    850                 855                 860                 


Glu Gly Ala Glu Trp Leu His Phe Ala Ser Cys Gly Glu Asp His Thr 
865                 870                 875                 880 


Val Lys Ile His Arg Val Asn Lys Cys Ala Leu 
                885                 890     


<210>  3521
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP3__Homo_sapiens__NP_001271151

<400>  3521

Met Met Leu Thr Ile Gly Asp Val Ile Lys Gln Leu Ile Glu Ala His 
1               5                   10                  15      


Glu Gln Gly Lys Asp Ile Asp Leu Asn Lys Val Lys Thr Lys Thr Ala 
            20                  25                  30          


Ala Lys Tyr Gly Leu Ser Ala Gln Pro Arg Leu Val Asp Ile Ile Ala 
        35                  40                  45              


Ala Val Pro Pro Gln Tyr Arg Lys Val Leu Met Pro Lys Leu Lys Ala 
    50                  55                  60                  


Lys Pro Ile Arg Thr Ala Ser Gly Ile Ala Val Val Ala Val Met Cys 
65                  70                  75                  80  


Lys Pro His Arg Cys Pro His Ile Ser Phe Thr Gly Asn Ile Cys Val 
                85                  90                  95      


Tyr Cys Pro Gly Gly Pro Asp Ser Asp Phe Glu Tyr Ser Thr Gln Ser 
            100                 105                 110         


Tyr Thr Gly Tyr Glu Pro Thr Ser Met Arg Ala Ile Arg Ala Arg Tyr 
        115                 120                 125             


Asp Pro Phe Leu Gln Thr Arg His Arg Ile Glu Gln Leu Lys Gln Leu 
    130                 135                 140                 


Gly His Ser Val Asp Lys Val Glu Phe Ile Val Met Gly Gly Thr Phe 
145                 150                 155                 160 


Met Ala Leu Pro Glu Glu Tyr Arg Asp Tyr Phe Ile Arg Asn Leu His 
                165                 170                 175     


Asp Ala Leu Ser Gly His Thr Ser Asn Asn Ile Tyr Glu Ala Val Lys 
            180                 185                 190         


Tyr Ser Glu Arg Ser Leu Thr Lys Cys Ile Gly Ile Thr Ile Glu Thr 
        195                 200                 205             


Arg Pro Asp Tyr Cys Met Lys Arg His Leu Ser Asp Met Leu Thr Tyr 
    210                 215                 220                 


Gly Cys Thr Arg Leu Glu Ile Gly Val Gln Ser Val Tyr Glu Asp Val 
225                 230                 235                 240 


Ala Arg Asp Thr Asn Arg Gly His Thr Val Lys Ala Val Cys Glu Ser 
                245                 250                 255     


Phe His Leu Ala Lys Asp Ser Gly Phe Lys Val Val Ala His Met Met 
            260                 265                 270         


Pro Asp Leu Pro Asn Val Gly Leu Glu Arg Asp Ile Glu Gln Phe Thr 
        275                 280                 285             


Glu Phe Phe Glu Asn Pro Ala Phe Arg Pro Asp Gly Leu Lys Leu Tyr 
    290                 295                 300                 


Pro Thr Leu Val Ile Arg Gly Thr Gly Leu Tyr Glu Leu Trp Lys Ser 
305                 310                 315                 320 


Gly Arg Tyr Lys Ser Tyr Ser Pro Ser Asp Leu Val Glu Leu Val Ala 
                325                 330                 335     


Arg Ile Leu Ala Leu Val Pro Pro Trp Thr Arg Val Tyr Arg Val Gln 
            340                 345                 350         


Arg Asp Ile Pro Met Pro Leu Val Ser Ser Gly Val Glu His Gly Asn 
        355                 360                 365             


Leu Arg Glu Leu Ala Leu Ala Arg Met Lys Asp Leu Gly Ile Gln Cys 
    370                 375                 380                 


Arg Asp Val Arg Thr Arg Glu Val Gly Ile Gln Glu Ile His His Lys 
385                 390                 395                 400 


Val Arg Pro Tyr Gln Val Glu Leu Val Arg Arg Asp Tyr Val Ala Asn 
                405                 410                 415     


Gly Gly Trp Glu Thr Phe Leu Ser Tyr Glu Asp Pro Asp Gln Asp Ile 
            420                 425                 430         


Leu Ile Gly Leu Leu Arg Leu Arg Lys Cys Ser Glu Glu Thr Phe Arg 
        435                 440                 445             


Phe Glu Leu Gly Gly Gly Val Ser Ile Val Arg Glu Leu His Val Tyr 
    450                 455                 460                 


Gly Ser Val Val Pro Val Ser Ser Arg Asp Pro Thr Lys Phe Gln His 
465                 470                 475                 480 


Gln Gly Phe Gly Met Leu Leu Met Glu Glu Ala Glu Arg Ile Ala Arg 
                485                 490                 495     


Glu Glu His Gly Ser Gly Lys Ile Ala Val Ile Ser Gly Val Gly Thr 
            500                 505                 510         


Arg Asn Tyr Tyr Arg Lys Ile Gly Tyr Arg Leu Gln Gly Pro Tyr Met 
        515                 520                 525             


Val Lys Met Leu Lys 
    530             


<210>  3522
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP4__Homo_sapiens__NP_001275654

<400>  3522

Met Ala Ala Val Ala Thr Cys Gly Ser Val Ala Ala Ser Thr Gly Ser 
1               5                   10                  15      


Ala Val Ala Thr Ala Ser Lys Ser Asn Val Thr Ser Phe Gln Arg Arg 
            20                  25                  30          


Gly Pro Arg Ala Ser Val Thr Asn Asp Ser Gly Pro Arg Leu Val Ser 
        35                  40                  45              


Ile Ala Gly Thr Arg Pro Ser Val Arg Asn Gly Gln Leu Leu Val Ser 
    50                  55                  60                  


Thr Gly Leu Pro Ala Leu Asp Gln Leu Leu Gly Gly Gly Leu Ala Val 
65                  70                  75                  80  


Gly Thr Val Leu Leu Ile Glu Glu Asp Lys Tyr Asn Ile Tyr Ser Pro 
                85                  90                  95      


Leu Leu Phe Lys Tyr Phe Leu Ala Glu Gly Ile Val Asn Gly His Thr 
            100                 105                 110         


Leu Leu Val Ala Ser Ala Lys Glu Asp Pro Ala Asn Ile Leu Gln Glu 
        115                 120                 125             


Leu Pro Ala Pro Leu Leu Asp Asp Lys Cys Lys Lys Glu Phe Asp Glu 
    130                 135                 140                 


Asp Val Tyr Asn His Lys Thr Pro Glu Ser Asn Ile Lys Met Lys Ile 
145                 150                 155                 160 


Ala Trp Arg Tyr Gln Leu Leu Pro Lys Met Glu Gln Ile Gly Pro Val 
                165                 170                 175     


Ser Ser Ser Arg Phe Gly His Tyr Tyr Asp Ala Ser Lys Arg Met Pro 
            180                 185                 190         


Gln Glu Leu Ile Glu Ala Ser Asn Trp His Gly Phe Phe Leu Pro Glu 
        195                 200                 205             


Lys Ile Ser Ser Thr Leu Lys Val Glu Pro Cys Ser Leu Thr Pro Gly 
    210                 215                 220                 


Tyr Thr Lys Leu Leu Gln Phe Ile Gln Asn Ile Ile Tyr Glu Glu Gly 
225                 230                 235                 240 


Phe Asp Gly Ser Asn Pro Gln Lys Lys Gln Arg Asn Ile Leu Arg Ile 
                245                 250                 255     


Gly Ile Gln Asn Leu Gly Ser Pro Leu Trp Gly Asp Asp Ile Cys Cys 
            260                 265                 270         


Ala Glu Asn Gly Gly Asn Ser His Ser Leu Thr Lys Phe Leu Tyr Val 
        275                 280                 285             


Leu Arg Gly Leu Leu Arg Thr Ser Leu Ser Ala Cys Ile Ile Thr Met 
    290                 295                 300                 


Pro Thr His Leu Ile Gln Asn Lys Ala Ile Ile Ala Arg Val Thr Thr 
305                 310                 315                 320 


Leu Ser Asp Val Val Val Gly Leu Glu Ser Phe Ile Gly Ser Glu Arg 
                325                 330                 335     


Glu Thr Asn Pro Leu Tyr Lys Asp Tyr His Gly Leu Ile His Ile Arg 
            340                 345                 350         


Gln Ile Pro Arg Leu Asn Asn Leu Ile Cys Asp Glu Ser Asp Val Lys 
        355                 360                 365             


Asp Leu Ala Phe Lys Leu Lys Arg Lys Leu Phe Thr Ile Glu Trp Val 
    370                 375                 380                 


Gln Asp Asn Tyr Leu Arg Gln Glu Arg Asn Ile Tyr Pro Pro Gly Phe 
385                 390                 395                 400 


Ser Tyr Leu Leu Lys Gln Lys Asp Ser Ala Trp Gly Glu Gly Ser Leu 
                405                 410                 415     


Gln His Ser Thr Phe Leu Met Ser Phe Leu Ala Lys Ala Thr Ala Phe 
            420                 425                 430         


Ala Ser Arg Leu Val Arg His Ser Glu Pro Leu Lys Gln Asn Gly Ser 
        435                 440                 445             


Gly Arg Ile Arg Gln Ala Ala Gly Pro Arg Leu Trp His Asp Gly Arg 
    450                 455                 460                 


Arg Gln Glu Ala Pro Gly Leu Leu Gly Ile Pro Pro 
465                 470                 475     


<210>  3523
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP6__Homo_sapiens__NP_001026873

<400>  3523

Met Phe Val Glu Leu Asn Asn Leu Leu Asn Thr Thr Pro Asp Arg Ala 
1               5                   10                  15      


Glu Gln Gly Lys Leu Thr Leu Leu Cys Asp Ala Lys Thr Asp Gly Ser 
            20                  25                  30          


Phe Leu Val His His Phe Leu Ser Phe Tyr Leu Lys Ala Asn Cys Lys 
        35                  40                  45              


Val Cys Phe Val Ala Leu Ile Gln Ser Phe Ser His Tyr Ser Ile Val 
    50                  55                  60                  


Gly Gln Lys Leu Gly Val Ser Leu Thr Met Ala Arg Glu Arg Gly Gln 
65                  70                  75                  80  


Leu Val Phe Leu Glu Gly Leu Lys Ser Ala Val Asp Val Val Phe Gln 
                85                  90                  95      


Ala Gln Lys Glu Pro His Pro Leu Gln Phe Leu Arg Glu Ala Asn Ala 
            100                 105                 110         


Gly Asn Leu Lys Pro Leu Phe Glu Phe Val Arg Glu Ala Leu Lys Pro 
        115                 120                 125             


Val Asp Ser Gly Glu Ala Arg Trp Thr Tyr Pro Val Leu Leu Val Asp 
    130                 135                 140                 


Asp Leu Ser Val Leu Leu Ser Leu Gly Met Gly Ala Val Ala Val Leu 
145                 150                 155                 160 


Asp Phe Ile His Tyr Cys Arg Ala Thr Val Cys Trp Glu Leu Lys Gly 
                165                 170                 175     


Asn Met Val Val Leu Val His Asp Ser Gly Asp Ala Glu Asp Glu Glu 
            180                 185                 190         


Asn Asp Ile Leu Leu Asn Gly Leu Ser His Gln Ser His Leu Ile Leu 
        195                 200                 205             


Arg Ala Glu Gly Leu Ala Thr Gly Phe Cys Arg Asp Val His Gly Gln 
    210                 215                 220                 


Leu Arg Ile Leu Trp Arg Arg Pro Ser Gln Pro Ala Val His Arg Asp 
225                 230                 235                 240 


Gln Ser Phe Thr Tyr Gln Tyr Lys Ile Gln Asp Lys Ser Val Ser Phe 
                245                 250                 255     


Phe Ala Lys Gly Met Ser Pro Ala Val Leu 
            260                 265     


<210>  3524
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELSPBP1__Homo_sapiens__NP_071425

<400>  3524

Met Thr Arg Trp Ser Ser Tyr Leu Leu Gly Trp Thr Thr Phe Leu Leu 
1               5                   10                  15      


Tyr Ser Tyr Glu Ser Ser Gly Gly Met His Glu Glu Cys Val Phe Pro 
            20                  25                  30          


Phe Thr Tyr Lys Gly Ser Val Tyr Phe Thr Cys Thr His Ile His Ser 
        35                  40                  45              


Leu Ser Pro Trp Cys Ala Thr Arg Ala Val Tyr Asn Gly Gln Trp Lys 
    50                  55                  60                  


Tyr Cys Gln Ser Glu Asp Tyr Pro Arg Cys Ile Phe Pro Phe Ile Tyr 
65                  70                  75                  80  


Arg Gly Lys Ala Tyr Asn Ser Cys Ile Ser Gln Gly Ser Phe Leu Gly 
                85                  90                  95      


Ser Leu Trp Cys Ser Val Thr Ser Val Phe Asp Glu Lys Gln Gln Trp 
            100                 105                 110         


Lys Phe Cys Glu Thr Asn Glu Tyr Gly Gly Asn Ser Leu Arg Lys Pro 
        115                 120                 125             


Cys Ile Phe Pro Ser Ile Tyr Arg Asn Asn Val Val Ser Asp Cys Met 
    130                 135                 140                 


Glu Asp Glu Ser Asn Lys Leu Trp Cys Pro Thr Thr Glu Asn Met Asp 
145                 150                 155                 160 


Lys Asp Gly Lys Trp Ser Phe Cys Ala Asp Thr Arg Ile Ser Ala Leu 
                165                 170                 175     


Val Pro Gly Phe Pro Cys His Phe Pro Phe Asn Tyr Lys Asn Lys Asn 
            180                 185                 190         


Tyr Phe Asn Cys Thr Asn Glu Gly Ser Lys Glu Asn Leu Val Trp Cys 
        195                 200                 205             


Ala Thr Ser Tyr Asn Tyr Asp Gln Asp His Thr Trp Val Tyr Cys 
    210                 215                 220             


<210>  3525
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMB__Homo_sapiens__NP_940851

<400>  3525

Met Arg Ala Leu Pro Gly Leu Leu Glu Ala Arg Ala Arg Thr Pro Arg 
1               5                   10                  15      


Leu Leu Leu Leu Gln Cys Leu Leu Ala Ala Ala Arg Pro Ser Ser Ala 
            20                  25                  30          


Asp Gly Ser Ala Pro Asp Ser Pro Phe Thr Ser Pro Pro Leu Arg Glu 
        35                  40                  45              


Glu Ile Met Ala Asn Asn Phe Ser Leu Glu Ser His Asn Ile Ser Leu 
    50                  55                  60                  


Thr Glu His Ser Ser Met Pro Val Glu Lys Asn Ile Thr Leu Glu Arg 
65                  70                  75                  80  


Pro Ser Asn Val Asn Leu Thr Cys Gln Phe Thr Thr Ser Gly Asp Leu 
                85                  90                  95      


Asn Ala Val Asn Val Thr Trp Lys Lys Asp Gly Glu Gln Leu Glu Asn 
            100                 105                 110         


Asn Tyr Leu Val Ser Ala Thr Gly Ser Thr Leu Tyr Thr Gln Tyr Arg 
        115                 120                 125             


Phe Thr Ile Ile Asn Ser Lys Gln Met Gly Ser Tyr Ser Cys Phe Phe 
    130                 135                 140                 


Arg Glu Glu Lys Glu Gln Arg Gly Thr Phe Asn Phe Lys Val Pro Glu 
145                 150                 155                 160 


Leu His Gly Lys Asn Lys Pro Leu Ile Ser Tyr Val Gly Asp Ser Thr 
                165                 170                 175     


Val Leu Thr Cys Lys Cys Gln Asn Cys Phe Pro Leu Asn Trp Thr Trp 
            180                 185                 190         


Tyr Ser Ser Asn Gly Ser Val Lys Val Pro Val Gly Val Gln Met Asn 
        195                 200                 205             


Lys Tyr Val Ile Asn Gly Thr Tyr Ala Asn Glu Thr Lys Leu Lys Ile 
    210                 215                 220                 


Thr Gln Leu Leu Glu Glu Asp Gly Glu Ser Tyr Trp Cys Arg Ala Leu 
225                 230                 235                 240 


Phe Gln Leu Gly Glu Ser Glu Glu His Ile Glu Leu Val Val Leu Ser 
                245                 250                 255     


Tyr Leu Val Pro Leu Lys Pro Phe Leu Val Ile Val Ala Glu Val Ile 
            260                 265                 270         


Leu Leu Val Ala Thr Ile Leu Leu Cys Glu Lys Tyr Thr Gln Lys Lys 
        275                 280                 285             


Lys Lys His Ser Asp Glu Gly Lys Glu Phe Glu Gln Ile Glu Gln Leu 
    290                 295                 300                 


Lys Ser Asp Asp Ser Asn Gly Ile Glu Asn Asn Val Pro Arg His Arg 
305                 310                 315                 320 


Lys Asn Glu Ser Leu Gly Gln 
                325         


<210>  3526
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMC10__Homo_sapiens__NP_778233

<400>  3526

Met Ala Ala Ala Ser Ala Gly Ala Thr Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Met Ala Val Ala Ala Pro Ser Arg Ala Arg Gly Ser Gly Cys Arg Ala 
            20                  25                  30          


Gly Thr Gly Ala Arg Gly Ala Gly Ala Glu Gly Arg Glu Gly Glu Ala 
        35                  40                  45              


Cys Gly Thr Val Gly Leu Leu Leu Glu His Ser Phe Glu Ile Asp Asp 
    50                  55                  60                  


Ser Ala Asn Phe Arg Lys Arg Gly Ser Leu Leu Trp Asn Gln Gln Asp 
65                  70                  75                  80  


Gly Thr Leu Ser Leu Ser Gln Arg Gln Leu Ser Glu Glu Glu Arg Gly 
                85                  90                  95      


Arg Leu Arg Asp Val Ala Ala Leu Asn Gly Leu Tyr Arg Val Arg Ile 
            100                 105                 110         


Pro Arg Arg Pro Gly Ala Leu Asp Gly Leu Glu Ala Gly Gly Tyr Val 
        115                 120                 125             


Ser Ser Phe Val Pro Ala Cys Ser Leu Val Glu Ser His Leu Ser Asp 
    130                 135                 140                 


Gln Leu Thr Leu His Val Asp Val Ala Gly Asn Val Val Gly Val Ser 
145                 150                 155                 160 


Val Val Thr His Pro Gly Gly Cys Arg Gly His Glu Val Glu Asp Val 
                165                 170                 175     


Asp Leu Glu Leu Phe Asn Thr Ser Val Gln Leu Gln Pro Pro Thr Thr 
            180                 185                 190         


Ala Pro Gly Pro Glu Thr Ala Ala Phe Ile Glu Arg Leu Glu Met Glu 
        195                 200                 205             


Gln Ala Gln Lys Ala Lys Asn Pro Gln Glu Gln Lys Ser Phe Phe Ala 
    210                 215                 220                 


Lys Tyr Trp His Ile Ile Leu Gly Gly Ala Val Leu Leu Thr Ala Leu 
225                 230                 235                 240 


Arg Pro Ala Ala Pro Gly Pro Ala Pro Pro Pro Gln Glu Ala 
                245                 250                 


<210>  3527
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMC2__Homo_sapiens__NP_055488

<400>  3527

Met Ala Lys Val Ser Glu Leu Tyr Asp Val Thr Trp Glu Glu Met Arg 
1               5                   10                  15      


Asp Lys Met Arg Lys Trp Arg Glu Glu Asn Ser Arg Asn Ser Glu Gln 
            20                  25                  30          


Ile Val Glu Val Gly Glu Glu Leu Ile Asn Glu Tyr Ala Ser Lys Leu 
        35                  40                  45              


Gly Asp Asp Ile Trp Ile Ile Tyr Glu Gln Val Met Ile Ala Ala Leu 
    50                  55                  60                  


Asp Tyr Gly Arg Asp Asp Leu Ala Leu Phe Cys Leu Gln Glu Leu Arg 
65                  70                  75                  80  


Arg Gln Phe Pro Gly Ser His Arg Val Lys Arg Leu Thr Gly Met Arg 
                85                  90                  95      


Phe Glu Ala Met Glu Arg Tyr Asp Asp Ala Ile Gln Leu Tyr Asp Arg 
            100                 105                 110         


Ile Leu Gln Glu Asp Pro Thr Asn Thr Ala Ala Arg Lys Arg Lys Ile 
        115                 120                 125             


Ala Ile Arg Lys Ala Gln Gly Lys Asn Val Glu Ala Ile Arg Glu Leu 
    130                 135                 140                 


Asn Glu Tyr Leu Glu Gln Phe Val Gly Asp Gln Glu Ala Trp His Glu 
145                 150                 155                 160 


Leu Ala Glu Leu Tyr Ile Asn Glu His Asp Tyr Ala Lys Ala Ala Phe 
                165                 170                 175     


Cys Leu Glu Glu Leu Met Met Thr Asn Pro His Asn His Leu Tyr Cys 
            180                 185                 190         


Gln Gln Tyr Ala Glu Val Lys Tyr Thr Gln Gly Gly Leu Glu Asn Leu 
        195                 200                 205             


Glu Leu Ser Arg Lys Tyr Phe Ala Gln Ala Leu Lys Leu Asn Asn Arg 
    210                 215                 220                 


Asn Met Arg Ala Leu Phe Gly Leu Tyr Met Ser Ala Ser His Ile Ala 
225                 230                 235                 240 


Ser Asn Pro Lys Ala Ser Ala Lys Thr Lys Lys Asp Asn Met Lys Tyr 
                245                 250                 255     


Ala Ser Trp Ala Ala Ser Gln Ile Asn Arg Ala Tyr Gln Phe Ala Gly 
            260                 265                 270         


Arg Ser Lys Lys Glu Thr Lys Tyr Ser Leu Lys Ala Val Glu Asp Met 
        275                 280                 285             


Leu Glu Thr Leu Gln Ile Thr Gln Ser 
    290                 295         


<210>  3528
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMC3__Homo_sapiens__NP_060917

<400>  3528

Met Ala Gly Pro Glu Leu Leu Leu Asp Ser Asn Ile Arg Leu Trp Val 
1               5                   10                  15      


Val Leu Pro Ile Val Ile Ile Thr Phe Phe Val Gly Met Ile Arg His 
            20                  25                  30          


Tyr Val Ser Ile Leu Leu Gln Ser Asp Lys Lys Leu Thr Gln Glu Gln 
        35                  40                  45              


Val Ser Asp Ser Gln Val Leu Ile Arg Ser Arg Val Leu Arg Glu Asn 
    50                  55                  60                  


Gly Lys Tyr Ile Pro Lys Gln Ser Phe Leu Thr Arg Lys Tyr Tyr Phe 
65                  70                  75                  80  


Asn Asn Pro Glu Asp Gly Phe Phe Lys Lys Thr Lys Arg Lys Val Val 
                85                  90                  95      


Pro Pro Ser Pro Met Thr Asp Pro Thr Met Leu Thr Asp Met Met Lys 
            100                 105                 110         


Gly Asn Val Thr Asn Val Leu Pro Met Ile Leu Ile Gly Gly Trp Ile 
        115                 120                 125             


Asn Met Thr Phe Ser Gly Phe Val Thr Thr Lys Val Pro Phe Pro Leu 
    130                 135                 140                 


Thr Leu Arg Phe Lys Pro Met Leu Gln Gln Gly Ile Glu Leu Leu Thr 
145                 150                 155                 160 


Leu Asp Ala Ser Trp Val Ser Ser Ala Ser Trp Tyr Phe Leu Asn Val 
                165                 170                 175     


Phe Gly Leu Arg Ser Ile Tyr Ser Leu Ile Leu Gly Gln Asp Asn Ala 
            180                 185                 190         


Ala Asp Gln Ser Arg Met Met Gln Glu Gln Met Thr Gly Ala Ala Met 
        195                 200                 205             


Ala Met Pro Ala Asp Thr Asn Lys Ala Phe Lys Thr Glu Trp Glu Ala 
    210                 215                 220                 


Leu Glu Leu Thr Asp His Gln Trp Ala Leu Asp Asp Val Glu Glu Glu 
225                 230                 235                 240 


Leu Met Ala Lys Asp Leu His Phe Glu Gly Met Phe Lys Lys Glu Leu 
                245                 250                 255     


Gln Thr Ser Ile Phe 
            260     


<210>  3529
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMC7__Homo_sapiens__NP_064539

<400>  3529

Met Ala Ala Ala Leu Trp Gly Phe Phe Pro Val Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Gly Asp Val Gln Ser Ser Glu Val Pro Gly Ala Ala Ala Glu 
            20                  25                  30          


Gly Ser Gly Gly Ser Gly Val Gly Ile Gly Asp Arg Phe Lys Ile Glu 
        35                  40                  45              


Gly Arg Ala Val Val Pro Gly Val Lys Pro Gln Asp Trp Ile Ser Ala 
    50                  55                  60                  


Ala Arg Val Leu Val Asp Gly Glu Glu His Val Gly Phe Leu Lys Thr 
65                  70                  75                  80  


Asp Gly Ser Phe Val Val His Asp Ile Pro Ser Gly Ser Tyr Val Val 
                85                  90                  95      


Glu Val Val Ser Pro Ala Tyr Arg Phe Asp Pro Val Arg Val Asp Ile 
            100                 105                 110         


Thr Ser Lys Gly Lys Met Arg Ala Arg Tyr Val Asn Tyr Ile Lys Thr 
        115                 120                 125             


Ser Glu Val Val Arg Leu Pro Tyr Pro Leu Gln Met Lys Ser Ser Gly 
    130                 135                 140                 


Pro Pro Ser Tyr Phe Ile Lys Arg Glu Ser Trp Gly Trp Thr Asp Phe 
145                 150                 155                 160 


Leu Met Asn Pro Met Val Met Met Met Val Leu Pro Leu Leu Ile Phe 
                165                 170                 175     


Val Leu Leu Pro Lys Val Val Asn Thr Ser Asp Pro Asp Met Arg Arg 
            180                 185                 190         


Glu Met Glu Gln Ser Met Asn Met Leu Asn Ser Asn His Glu Leu Pro 
        195                 200                 205             


Asp Val Ser Glu Phe Met Thr Arg Leu Phe Ser Ser Lys Ser Ser Gly 
    210                 215                 220                 


Lys Ser Ser Ser Gly Ser Ser Lys Thr Gly Lys Ser Gly Ala Gly Lys 
225                 230                 235                 240 


Arg Arg 
        


<210>  3530
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMC8__Homo_sapiens__NP_001135760

<400>  3530

Met Pro Gly Val Lys Leu Thr Thr Gln Ala Tyr Cys Lys Met Val Leu 
1               5                   10                  15      


His Gly Ala Lys Tyr Pro His Cys Ala Val Asn Gly Leu Leu Val Ala 
            20                  25                  30          


Glu Lys Gln Lys Pro Arg Lys Glu His Leu Pro Leu Gly Gly Pro Gly 
        35                  40                  45              


Ala His His Thr Leu Phe Val Asp Cys Ile Pro Leu Phe His Gly Thr 
    50                  55                  60                  


Leu Ala Leu Ala Pro Met Leu Glu Val Ala Leu Thr Leu Ile Asp Ser 
65                  70                  75                  80  


Trp Cys Lys Asp His Ser Tyr Val Ile Ala Gly Tyr Tyr Gln Ala Asn 
                85                  90                  95      


Glu Arg Val Lys Asp Ala Ser Pro Asn Gln Val Ala Glu Lys Val Ala 
            100                 105                 110         


Ser Arg Ile Ala Glu Gly Phe Ser Asp Thr Ala Leu Ile Met 
        115                 120                 125     


<210>  3531
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMCN__Homo_sapiens__NP_001153166

<400>  3531

Met Glu Leu Leu Gln Val Thr Ile Leu Phe Leu Leu Pro Ser Ile Cys 
1               5                   10                  15      


Ser Ser Asn Ser Thr Gly Val Leu Glu Ala Ala Asn Asn Ser Leu Val 
            20                  25                  30          


Val Thr Thr Thr Lys Pro Ser Ile Thr Thr Pro Asn Thr Glu Ser Leu 
        35                  40                  45              


Gln Lys Asn Val Val Thr Pro Thr Thr Gly Thr Thr Pro Lys Gly Thr 
    50                  55                  60                  


Ile Thr Asn Glu Leu Leu Lys Met Ser Leu Met Ser Thr Ala Thr Phe 
65                  70                  75                  80  


Leu Thr Ser Lys Asp Glu Gly Leu Lys Ala Thr Thr Thr Asp Val Arg 
                85                  90                  95      


Lys Asn Asp Ser Ile Ile Ser Asn Val Thr Val Thr Ser Val Thr Leu 
            100                 105                 110         


Pro Asn Ala Val Ser Thr Leu Gln Ser Ser Lys Pro Lys Ser Ser Val 
        115                 120                 125             


Leu Gln Pro Asp Ala Ser Pro Ser Lys Thr Gly Thr Leu Thr Ser Ile 
    130                 135                 140                 


Pro Val Thr Ile Pro Glu Asn Thr Ser Gln Ser Gln Val Ile Gly Thr 
145                 150                 155                 160 


Glu Gly Gly Lys Asn Ala Ser Thr Ser Ala Thr Ser Arg Ser Tyr Ser 
                165                 170                 175     


Ser Ile Ile Leu Pro Val Val Ile Ala Leu Ile Val Ile Thr Leu Ser 
            180                 185                 190         


Val Phe Val Leu Val Gly Leu Tyr Arg Met Cys Trp Lys Ala Asp Pro 
        195                 200                 205             


Gly Thr Pro Glu Asn Gly Asn Asp Gln Pro Gln Ser Asp Lys Glu Ser 
    210                 215                 220                 


Val Lys Leu Leu Thr Val Lys Thr Ile Ser His Glu Ser Gly Glu His 
225                 230                 235                 240 


Ser Ala Gln Gly Lys Thr Lys Asn 
                245             


<210>  3532
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMD__Homo_sapiens__NP_000108

<400>  3532

Met Asp Asn Tyr Ala Asp Leu Ser Asp Thr Glu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Arg Arg Tyr Asn Ile Pro His Gly Pro Val Val Gly Ser Thr Arg Arg 
            20                  25                  30          


Leu Tyr Glu Lys Lys Ile Phe Glu Tyr Glu Thr Gln Arg Arg Arg Leu 
        35                  40                  45              


Ser Pro Pro Ser Ser Ser Ala Ala Ser Ser Tyr Ser Phe Ser Asp Leu 
    50                  55                  60                  


Asn Ser Thr Arg Gly Asp Ala Asp Met Tyr Asp Leu Pro Lys Lys Glu 
65                  70                  75                  80  


Asp Ala Leu Leu Tyr Gln Ser Lys Gly Tyr Asn Asp Asp Tyr Tyr Glu 
                85                  90                  95      


Glu Ser Tyr Phe Thr Thr Arg Thr Tyr Gly Glu Pro Glu Ser Ala Gly 
            100                 105                 110         


Pro Ser Arg Ala Val Arg Gln Ser Val Thr Ser Phe Pro Asp Ala Asp 
        115                 120                 125             


Ala Phe His His Gln Val His Asp Asp Asp Leu Leu Ser Ser Ser Glu 
    130                 135                 140                 


Glu Glu Cys Lys Asp Arg Glu Arg Pro Met Tyr Gly Arg Asp Ser Ala 
145                 150                 155                 160 


Tyr Gln Ser Ile Thr His Tyr Arg Pro Val Ser Ala Ser Arg Ser Ser 
                165                 170                 175     


Leu Asp Leu Ser Tyr Tyr Pro Thr Ser Ser Ser Thr Ser Phe Met Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Trp Leu Thr Arg Arg Ala Ile Arg Pro 
        195                 200                 205             


Glu Asn Arg Ala Pro Gly Ala Gly Leu Gly Gln Asp Arg Gln Val Pro 
    210                 215                 220                 


Leu Trp Gly Gln Leu Leu Leu Phe Leu Val Phe Val Ile Val Leu Phe 
225                 230                 235                 240 


Phe Ile Tyr His Phe Met Gln Ala Glu Glu Gly Asn Pro Phe 
                245                 250                 


<210>  3533
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EME1__Homo_sapiens__NP_689676

<400>  3533

Met Ala Leu Lys Lys Ser Ser Pro Ser Leu Asp Ser Gly Asp Ser Asp 
1               5                   10                  15      


Ser Glu Glu Leu Pro Thr Phe Ala Phe Leu Lys Lys Glu Pro Ser Ser 
            20                  25                  30          


Thr Lys Arg Arg Gln Pro Glu Arg Glu Glu Lys Ile Val Val Val Asp 
        35                  40                  45              


Ile Ser Asp Cys Glu Ala Ser Cys Pro Pro Ala Pro Glu Leu Phe Ser 
    50                  55                  60                  


Pro Pro Val Pro Glu Ile Ala Glu Thr Val Thr Gln Thr Gln Pro Val 
65                  70                  75                  80  


Arg Leu Leu Ser Ser Glu Ser Glu Asp Glu Glu Glu Phe Ile Pro Leu 
                85                  90                  95      


Ala Gln Arg Leu Thr Cys Lys Phe Leu Thr His Lys Gln Leu Ser Pro 
            100                 105                 110         


Glu Asp Ser Ser Ser Pro Val Lys Ser Val Leu Asp His Gln Asn Asn 
        115                 120                 125             


Glu Gly Ala Ser Cys Asp Trp Lys Lys Pro Phe Pro Lys Ile Pro Glu 
    130                 135                 140                 


Val Pro Leu His Asp Thr Pro Glu Arg Ser Ala Ala Asp Asn Lys Asp 
145                 150                 155                 160 


Leu Ile Leu Asp Pro Cys Cys Gln Leu Pro Ala Tyr Leu Ser Thr Cys 
                165                 170                 175     


Pro Gly Gln Ser Ser Ser Leu Ala Val Thr Lys Thr Asn Ser Asp Ile 
            180                 185                 190         


Leu Pro Pro Gln Lys Lys Thr Lys Pro Ser Gln Lys Val Gln Gly Arg 
        195                 200                 205             


Gly Ser His Gly Cys Arg Gln Gln Arg Gln Ala Arg Gln Lys Glu Ser 
    210                 215                 220                 


Thr Leu Arg Arg Gln Glu Arg Lys Asn Ala Ala Leu Val Thr Arg Met 
225                 230                 235                 240 


Lys Ala Gln Arg Pro Glu Glu Cys Leu Lys His Ile Ile Val Val Leu 
                245                 250                 255     


Asp Pro Val Leu Leu Gln Met Glu Gly Gly Gly Gln Leu Leu Gly Ala 
            260                 265                 270         


Leu Gln Thr Met Glu Cys Arg Cys Val Ile Glu Ala Gln Ala Val Pro 
        275                 280                 285             


Cys Ser Val Thr Trp Arg Arg Arg Ala Gly Pro Ser Glu Asp Arg Glu 
    290                 295                 300                 


Asp Trp Val Glu Glu Pro Thr Val Leu Val Leu Leu Arg Ala Glu Ala 
305                 310                 315                 320 


Phe Val Ser Met Ile Asp Asn Gly Lys Gln Gly Ser Leu Asp Ser Thr 
                325                 330                 335     


Met Lys Gly Lys Glu Thr Leu Gln Gly Phe Val Thr Asp Ile Thr Ala 
            340                 345                 350         


Lys Thr Ala Gly Lys Ala Leu Ser Leu Val Ile Val Asp Gln Glu Lys 
        355                 360                 365             


Cys Phe Ser Ala Gln Asn Pro Pro Arg Arg Gly Lys Gln Gly Ala Asn 
    370                 375                 380                 


Lys Gln Thr Lys Lys Gln Gln Gln Arg Gln Pro Glu Ala Ser Ile Gly 
385                 390                 395                 400 


Ser Met Val Ser Arg Val Asp Ala Glu Glu Ala Leu Val Asp Leu Gln 
                405                 410                 415     


Leu His Thr Glu Ala Gln Ala Gln Ile Val Gln Ser Trp Lys Glu Leu 
            420                 425                 430         


Ala Asp Phe Thr Cys Ala Phe Thr Lys Ala Val Ala Glu Ala Pro Phe 
        435                 440                 445             


Lys Lys Leu Arg Asp Glu Thr Thr Phe Ser Phe Cys Leu Glu Ser Asp 
    450                 455                 460                 


Trp Ala Gly Gly Val Lys Val Asp Leu Ala Gly Arg Gly Leu Ala Leu 
465                 470                 475                 480 


Val Trp Arg Arg Gln Ile Gln Gln Leu Asn Arg Val Ser Leu Glu Met 
                485                 490                 495     


Ala Ser Ala Val Val Asn Ala Tyr Pro Ser Pro Gln Leu Leu Val Gln 
            500                 505                 510         


Ala Tyr Gln Gln Cys Phe Ser Asp Lys Glu Arg Gln Asn Leu Leu Ala 
        515                 520                 525             


Asp Ile Gln Val Arg Arg Gly Glu Gly Val Thr Ser Thr Ser Arg Arg 
    530                 535                 540                 


Ile Gly Pro Glu Leu Ser Arg Arg Ile Tyr Leu Gln Met Thr Thr Leu 
545                 550                 555                 560 


Gln Pro His Leu Ser Leu Asp Ser Ala Asp 
                565                 570 


<210>  3534
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMG1__Homo_sapiens__NP_006322

<400>  3534

Met Ala Ala Pro Ser Asp Gly Phe Lys Pro Arg Glu Arg Ser Gly Gly 
1               5                   10                  15      


Glu Gln Ala Gln Asp Trp Asp Ala Leu Pro Pro Lys Arg Pro Arg Leu 
            20                  25                  30          


Gly Ala Gly Asn Lys Ile Gly Gly Arg Arg Leu Ile Val Val Leu Glu 
        35                  40                  45              


Gly Ala Ser Leu Glu Thr Val Lys Val Gly Lys Thr Tyr Glu Leu Leu 
    50                  55                  60                  


Asn Cys Asp Lys His Lys Ser Ile Leu Leu Lys Asn Gly Arg Asp Pro 
65                  70                  75                  80  


Gly Glu Ala Arg Pro Asp Ile Thr His Gln Ser Leu Leu Met Leu Met 
                85                  90                  95      


Asp Ser Pro Leu Asn Arg Ala Gly Leu Leu Gln Val Tyr Ile His Thr 
            100                 105                 110         


Gln Lys Asn Val Leu Ile Glu Val Asn Pro Gln Thr Arg Ile Pro Arg 
        115                 120                 125             


Thr Phe Asp Arg Phe Cys Gly Leu Met Val Gln Leu Leu His Lys Leu 
    130                 135                 140                 


Ser Val Arg Ala Ala Asp Gly Pro Gln Lys Leu Leu Lys Val Ile Lys 
145                 150                 155                 160 


Asn Pro Val Ser Asp His Phe Pro Val Gly Cys Met Lys Val Gly Thr 
                165                 170                 175     


Ser Phe Ser Ile Pro Val Val Ser Asp Val Arg Glu Leu Val Pro Ser 
            180                 185                 190         


Ser Asp Pro Ile Val Phe Val Val Gly Ala Phe Ala His Gly Lys Val 
        195                 200                 205             


Ser Val Glu Tyr Thr Glu Lys Met Val Ser Ile Ser Asn Tyr Pro Leu 
    210                 215                 220                 


Ser Ala Ala Leu Thr Cys Ala Lys Leu Thr Thr Ala Phe Glu Glu Val 
225                 230                 235                 240 


Trp Gly Val Ile 
                


<210>  3535
<211>  1016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMILIN1__Homo_sapiens__NP_008977

<400>  3535

Met Ala Pro Arg Thr Leu Trp Ser Cys Tyr Leu Cys Cys Leu Leu Thr 
1               5                   10                  15      


Ala Ala Ala Gly Ala Ala Ser Tyr Pro Pro Arg Gly Phe Ser Leu Tyr 
            20                  25                  30          


Thr Gly Ser Ser Gly Ala Leu Ser Pro Gly Gly Pro Gln Ala Gln Ile 
        35                  40                  45              


Ala Pro Arg Pro Ala Ser Arg His Arg Asn Trp Cys Ala Tyr Val Val 
    50                  55                  60                  


Thr Arg Thr Val Ser Cys Val Leu Glu Asp Gly Val Glu Thr Tyr Val 
65                  70                  75                  80  


Lys Tyr Gln Pro Cys Ala Trp Gly Gln Pro Gln Cys Pro Gln Ser Ile 
                85                  90                  95      


Met Tyr Arg Arg Phe Leu Arg Pro Arg Tyr Arg Val Ala Tyr Lys Thr 
            100                 105                 110         


Val Thr Asp Met Glu Trp Arg Cys Cys Gln Gly Tyr Gly Gly Asp Asp 
        115                 120                 125             


Cys Ala Glu Ser Pro Ala Pro Ala Leu Gly Pro Ala Ser Ser Thr Pro 
    130                 135                 140                 


Arg Pro Leu Ala Arg Pro Ala Arg Pro Asn Leu Ser Gly Ser Ser Ala 
145                 150                 155                 160 


Gly Ser Pro Leu Ser Gly Leu Gly Gly Glu Gly Pro Gly Glu Ser Glu 
                165                 170                 175     


Lys Val Gln Gln Leu Glu Glu Gln Val Gln Ser Leu Thr Lys Glu Leu 
            180                 185                 190         


Gln Gly Leu Arg Gly Val Leu Gln Gly Leu Ser Gly Arg Leu Ala Glu 
        195                 200                 205             


Asp Val Gln Arg Ala Val Glu Thr Ala Phe Asn Gly Arg Gln Gln Pro 
    210                 215                 220                 


Ala Asp Ala Ala Ala Arg Pro Gly Val His Glu Thr Leu Asn Glu Ile 
225                 230                 235                 240 


Gln His Gln Leu Gln Leu Leu Asp Thr Arg Val Ser Thr His Asp Gln 
                245                 250                 255     


Glu Leu Gly His Leu Asn Asn His His Gly Gly Ser Ser Ser Ser Gly 
            260                 265                 270         


Gly Ser Arg Ala Pro Ala Pro Ala Ser Ala Pro Pro Gly Pro Ser Glu 
        275                 280                 285             


Glu Leu Leu Arg Gln Leu Glu Gln Arg Leu Gln Glu Ser Cys Ser Val 
    290                 295                 300                 


Cys Leu Ala Gly Leu Asp Gly Phe Arg Arg Gln Gln Gln Glu Asp Arg 
305                 310                 315                 320 


Glu Arg Leu Arg Ala Met Glu Lys Leu Leu Ala Ser Val Glu Glu Arg 
                325                 330                 335     


Gln Arg His Leu Ala Gly Leu Ala Val Gly Arg Arg Pro Pro Gln Glu 
            340                 345                 350         


Cys Cys Ser Pro Glu Leu Gly Arg Arg Leu Ala Glu Leu Glu Arg Arg 
        355                 360                 365             


Leu Asp Val Val Ala Gly Ser Val Thr Val Leu Ser Gly Arg Arg Gly 
    370                 375                 380                 


Thr Glu Leu Gly Gly Ala Ala Gly Gln Gly Gly His Pro Pro Gly Tyr 
385                 390                 395                 400 


Thr Ser Leu Ala Ser Arg Leu Ser Arg Leu Glu Asp Arg Phe Asn Ser 
                405                 410                 415     


Thr Leu Gly Pro Ser Glu Glu Gln Glu Glu Ser Trp Pro Gly Ala Pro 
            420                 425                 430         


Gly Gly Leu Ser His Trp Leu Pro Ala Ala Arg Gly Arg Leu Glu Gln 
        435                 440                 445             


Leu Gly Gly Leu Leu Ala Asn Val Ser Gly Glu Leu Gly Gly Arg Leu 
    450                 455                 460                 


Asp Leu Leu Glu Glu Gln Val Ala Gly Ala Met Gln Ala Cys Gly Gln 
465                 470                 475                 480 


Leu Cys Ser Gly Ala Pro Gly Glu Gln Asp Ser Gln Val Ser Glu Ile 
                485                 490                 495     


Leu Ser Ala Leu Glu Arg Arg Val Leu Asp Ser Glu Gly Gln Leu Arg 
            500                 505                 510         


Leu Val Gly Ser Gly Leu His Thr Val Glu Ala Ala Gly Glu Ala Arg 
        515                 520                 525             


Gln Ala Thr Leu Glu Gly Leu Gln Glu Val Val Gly Arg Leu Gln Asp 
    530                 535                 540                 


Arg Val Asp Ala Gln Asp Glu Thr Ala Ala Glu Phe Thr Leu Arg Leu 
545                 550                 555                 560 


Asn Leu Thr Ala Ala Arg Leu Gly Gln Leu Glu Gly Leu Leu Gln Ala 
                565                 570                 575     


His Gly Asp Glu Gly Cys Gly Ala Cys Gly Gly Val Gln Glu Glu Leu 
            580                 585                 590         


Gly Arg Leu Arg Asp Gly Val Glu Arg Cys Ser Cys Pro Leu Leu Pro 
        595                 600                 605             


Pro Arg Gly Pro Gly Ala Gly Pro Gly Val Gly Gly Pro Ser Arg Gly 
    610                 615                 620                 


Pro Leu Asp Gly Phe Ser Val Phe Gly Gly Ser Ser Gly Ser Ala Leu 
625                 630                 635                 640 


Gln Ala Leu Gln Gly Glu Leu Ser Glu Val Ile Leu Ser Phe Ser Ser 
                645                 650                 655     


Leu Asn Asp Ser Leu Asn Glu Leu Gln Thr Thr Val Glu Gly Gln Gly 
            660                 665                 670         


Ala Asp Leu Ala Asp Leu Gly Ala Thr Lys Asp Arg Ile Ile Ser Glu 
        675                 680                 685             


Ile Asn Arg Leu Gln Gln Glu Ala Thr Glu His Ala Thr Glu Ser Glu 
    690                 695                 700                 


Glu Arg Phe Arg Gly Leu Glu Glu Gly Gln Ala Gln Ala Gly Gln Cys 
705                 710                 715                 720 


Pro Ser Leu Glu Gly Arg Leu Gly Arg Leu Glu Gly Val Cys Glu Arg 
                725                 730                 735     


Leu Asp Thr Val Ala Gly Gly Leu Gln Gly Leu Arg Glu Gly Leu Ser 
            740                 745                 750         


Arg His Val Ala Gly Leu Trp Ala Gly Leu Arg Glu Thr Asn Thr Thr 
        755                 760                 765             


Ser Gln Met Gln Ala Ala Leu Leu Glu Lys Leu Val Gly Gly Gln Ala 
    770                 775                 780                 


Gly Leu Gly Arg Arg Leu Gly Ala Leu Asn Ser Ser Leu Gln Leu Leu 
785                 790                 795                 800 


Glu Asp Arg Leu His Gln Leu Ser Leu Lys Asp Leu Thr Gly Pro Ala 
                805                 810                 815     


Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly 
            820                 825                 830         


Pro Ala Gly Pro Pro Gly Ser Pro Gly Lys Asp Gly Gln Glu Gly Pro 
        835                 840                 845             


Ile Gly Pro Pro Gly Pro Gln Gly Glu Gln Gly Val Glu Gly Ala Pro 
    850                 855                 860                 


Ala Ala Pro Val Pro Gln Val Ala Phe Ser Ala Ala Leu Ser Leu Pro 
865                 870                 875                 880 


Arg Ser Glu Pro Gly Thr Val Pro Phe Asp Arg Val Leu Leu Asn Asp 
                885                 890                 895     


Gly Gly Tyr Tyr Asp Pro Glu Thr Gly Val Phe Thr Ala Pro Leu Ala 
            900                 905                 910         


Gly Arg Tyr Leu Leu Ser Ala Val Leu Thr Gly His Arg His Glu Lys 
        915                 920                 925             


Val Glu Ala Val Leu Ser Arg Ser Asn Gln Gly Val Ala Arg Val Asp 
    930                 935                 940                 


Ser Gly Gly Tyr Glu Pro Glu Gly Leu Glu Asn Lys Pro Val Ala Glu 
945                 950                 955                 960 


Ser Gln Pro Ser Pro Gly Thr Leu Gly Val Phe Ser Leu Ile Leu Pro 
                965                 970                 975     


Leu Gln Ala Gly Asp Thr Val Cys Val Asp Leu Val Met Gly Gln Leu 
            980                 985                 990         


Ala His Ser Glu Glu Pro Leu Thr  Ile Phe Ser Gly Ala  Leu Leu Tyr 
        995                 1000                 1005             


Gly Asp  Pro Glu Leu Glu His  Ala 
    1010                 1015     


<210>  3536
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMILIN2__Homo_sapiens__NP_114437

<400>  3536

Met Trp Gln Pro Arg Arg Pro Trp Pro Arg Val Pro Trp Arg Trp Ala 
1               5                   10                  15      


Leu Ala Leu Leu Ala Leu Val Gly Ala Gly Leu Cys His Ala Gly Pro 
            20                  25                  30          


Gln Pro Gly Tyr Pro Ala Arg Pro Ser Ala Arg Asn Lys Asn Trp Cys 
        35                  40                  45              


Ala Tyr Ile Val Asn Lys Asn Val Ser Cys Ser Val Leu Glu Gly Ser 
    50                  55                  60                  


Glu Ser Phe Ile Gln Ala Gln Tyr Asn Cys Ala Trp Asn Gln Met Pro 
65                  70                  75                  80  


Cys Pro Ser Ala Leu Val Tyr Arg Val Asn Phe Arg Pro Arg Tyr Val 
                85                  90                  95      


Thr Arg Tyr Lys Thr Val Thr Gln Leu Glu Trp Arg Cys Cys Pro Gly 
            100                 105                 110         


Phe Arg Gly Gly Asp Cys Gln Glu Gly Pro Lys Asp Pro Val Lys Thr 
        115                 120                 125             


Leu Arg Pro Thr Pro Ala Arg Pro Arg Asn Ser Leu Lys Lys Ala Thr 
    130                 135                 140                 


Asp Asn Glu Pro Ser Gln Phe Ser Glu Pro Arg Lys Thr Leu Ser Pro 
145                 150                 155                 160 


Thr Gly Thr Ala Gln Pro Ser Trp Gly Val Asp Pro Lys Glu Gly Pro 
                165                 170                 175     


Gln Glu Leu Gln Glu Lys Lys Ile Gln Val Leu Glu Glu Lys Val Leu 
            180                 185                 190         


Arg Leu Thr Arg Thr Val Leu Asp Leu Gln Ser Ser Leu Ala Gly Val 
        195                 200                 205             


Ser Glu Asn Leu Lys His Ala Thr Gln Asp Asp Ala Ser Arg Thr Arg 
    210                 215                 220                 


Ala Pro Gly Leu Ser Ser Gln His Pro Lys Pro Asp Thr Thr Val Ser 
225                 230                 235                 240 


Gly Asp Thr Glu Thr Gly Gln Ser Pro Gly Val Phe Asn Thr Lys Glu 
                245                 250                 255     


Ser Gly Met Lys Asp Ile Lys Ser Glu Leu Ala Glu Val Lys Asp Thr 
            260                 265                 270         


Leu Lys Asn Lys Ser Asp Lys Leu Glu Glu Leu Asp Gly Lys Val Lys 
        275                 280                 285             


Gly Tyr Glu Gly Gln Leu Arg Gln Leu Gln Glu Ala Ala Gln Gly Pro 
    290                 295                 300                 


Thr Val Thr Met Thr Thr Asn Glu Leu Tyr Gln Ala Tyr Val Asp Ser 
305                 310                 315                 320 


Lys Ile Asp Ala Leu Arg Glu Glu Leu Met Glu Gly Met Asp Arg Lys 
                325                 330                 335     


Leu Ala Asp Leu Lys Asn Ser Cys Glu Tyr Lys Leu Thr Gly Leu Gln 
            340                 345                 350         


Gln Gln Cys Asp Asp Tyr Gly Ser Ser Tyr Leu Gly Val Ile Glu Leu 
        355                 360                 365             


Ile Gly Glu Lys Glu Thr Ser Leu Arg Lys Glu Ile Asn Asn Leu Arg 
    370                 375                 380                 


Ala Arg Leu Gln Glu Pro Ser Ala Gln Ala Asn Cys Cys Asp Ser Glu 
385                 390                 395                 400 


Lys Asn Gly Asp Ile Gly Gln Gln Ile Lys Thr Leu Asp Gln Lys Ile 
                405                 410                 415     


Glu Arg Val Ala Glu Ala Thr Arg Met Leu Asn Gly Arg Leu Asp Asn 
            420                 425                 430         


Glu Phe Asp Arg Leu Ile Val Pro Glu Pro Asp Val Asp Phe Asp Ala 
        435                 440                 445             


Lys Trp Asn Glu Leu Asp Ala Arg Ile Asn Val Thr Glu Lys Asn Ala 
    450                 455                 460                 


Glu Glu His Cys Phe Tyr Ile Glu Glu Thr Leu Arg Gly Ala Ile Asn 
465                 470                 475                 480 


Gly Glu Val Gly Asp Leu Lys Gln Leu Val Asp Gln Lys Ile Gln Ser 
                485                 490                 495     


Leu Glu Asp Arg Leu Gly Ser Val Leu Leu Gln Met Thr Asn Asn Thr 
            500                 505                 510         


Gly Ala Glu Leu Ser Pro Pro Gly Ala Ala Ala Leu Pro Gly Val Ser 
        515                 520                 525             


Gly Ser Gly Asp Glu Arg Val Met Met Glu Leu Asn His Leu Lys Asp 
    530                 535                 540                 


Lys Val Gln Val Val Glu Asp Ile Cys Leu Leu Asn Ile Gln Gly Lys 
545                 550                 555                 560 


Pro His Gly Met Glu Gly Ala Leu Pro Asn Arg Glu Asp Arg Ala Val 
                565                 570                 575     


Arg Asp Ser Leu His Leu Leu Lys Ser Leu Asn Asp Thr Met His Arg 
            580                 585                 590         


Lys Phe Gln Glu Thr Glu Gln Thr Ile Gln Lys Leu Gln Gln Asp Phe 
        595                 600                 605             


Ser Phe Leu Tyr Ser Gln Leu Asn His Thr Glu Asn Asp Val Thr His 
    610                 615                 620                 


Leu Gln Lys Glu Met Ser Asn Cys Arg Ala Gly Glu Asn Ala Gly Met 
625                 630                 635                 640 


Gly Arg Phe Thr Lys Val Gly Glu Gln Glu Arg Thr Val Asp Thr Leu 
                645                 650                 655     


Pro Ser Pro Gln His Pro Val Ala His Cys Cys Ser Gln Leu Glu Glu 
            660                 665                 670         


Arg Trp Gln Arg Leu Gln Ser Gln Val Ile Ser Glu Leu Asp Ala Cys 
        675                 680                 685             


Lys Glu Cys Thr Gln Gly Val Gln Arg Glu Val Ser Met Val Glu Gly 
    690                 695                 700                 


Arg Val Ser His Met Glu Lys Thr Cys Ser Lys Leu Asp Ser Ile Ser 
705                 710                 715                 720 


Gly Asn Leu Gln Arg Ile Lys Glu Gly Leu Asn Lys His Val Ser Ser 
                725                 730                 735     


Leu Trp Asn Cys Val Arg Gln Met Asn Gly Thr Leu Arg Ser His Ser 
            740                 745                 750         


Arg Asp Ile Ser Gly Leu Lys Asn Ser Val Gln Gln Phe Tyr Ser His 
        755                 760                 765             


Val Phe Gln Ile Ser Thr Asp Leu Gln Asp Leu Val Lys Phe Gln Pro 
    770                 775                 780                 


Ser Ala Lys Ala Pro Ser Pro Pro Pro Pro Ala Glu Ala Pro Lys Glu 
785                 790                 795                 800 


Pro Leu Gln Pro Glu Pro Ala Pro Pro Arg Pro Ser Gly Pro Ala Thr 
                805                 810                 815     


Ala Glu Asp Pro Gly Arg Arg Pro Val Leu Pro Gln Arg Pro Pro Glu 
            820                 825                 830         


Glu Arg Pro Pro Gln Pro Pro Gly Ser Thr Gly Val Ile Ala Glu Thr 
        835                 840                 845             


Gly Gln Ala Gly Pro Pro Ala Gly Ala Gly Val Ser Gly Arg Gly Leu 
    850                 855                 860                 


Pro Arg Gly Val Asp Gly Gln Thr Gly Ser Gly Thr Val Pro Gly Ala 
865                 870                 875                 880 


Glu Gly Phe Ala Gly Ala Pro Gly Tyr Pro Lys Ser Pro Pro Val Ala 
                885                 890                 895     


Ser Pro Gly Ala Pro Val Pro Ser Leu Val Ser Phe Ser Ala Gly Leu 
            900                 905                 910         


Thr Gln Lys Pro Phe Pro Ser Asp Gly Gly Val Val Leu Phe Asn Lys 
        915                 920                 925             


Val Leu Val Asn Asp Gly Asp Val Tyr Asn Pro Ser Thr Gly Val Phe 
    930                 935                 940                 


Thr Ala Pro Tyr Asp Gly Arg Tyr Leu Ile Thr Ala Thr Leu Thr Pro 
945                 950                 955                 960 


Glu Arg Asp Ala Tyr Val Glu Ala Val Leu Ser Val Ser Asn Ala Ser 
                965                 970                 975     


Val Ala Gln Leu His Thr Ala Gly Tyr Arg Arg Glu Phe Leu Glu Tyr 
            980                 985                 990         


His Arg Pro Pro Gly Ala Leu His  Thr Cys Gly Gly Pro  Gly Ala Phe 
        995                 1000                 1005             


His Leu  Ile Val His Leu Lys  Ala Gly Asp Ala Val  Asn Val Val 
    1010                 1015                 1020             


Val Thr  Gly Gly Lys Leu Ala  His Thr Asp Phe Asp  Glu Met Tyr 
    1025                 1030                 1035             


Ser Thr  Phe Ser Gly Val Phe  Leu Tyr Pro Phe Leu  Ser His Leu 
    1040                 1045                 1050             


<210>  3537
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMILIN3__Homo_sapiens__NP_443078

<400>  3537

Met Gly Arg Arg Arg Leu Leu Val Trp Leu Cys Ala Val Ala Ala Leu 
1               5                   10                  15      


Leu Ser Gly Ala Gln Ala Arg Gly Thr Pro Leu Leu Ala Arg Pro Ala 
            20                  25                  30          


Pro Pro Gly Ala Ser Arg Tyr Ser Leu Tyr Thr Thr Gly Trp Arg Pro 
        35                  40                  45              


Arg Leu Arg Pro Gly Pro His Lys Ala Leu Cys Ala Tyr Val Val His 
    50                  55                  60                  


Arg Asn Val Thr Cys Ile Leu Gln Glu Gly Ala Glu Ser Tyr Val Lys 
65                  70                  75                  80  


Ala Glu Tyr Arg Gln Cys Arg Trp Gly Pro Lys Cys Pro Gly Thr Val 
                85                  90                  95      


Thr Tyr Arg Thr Val Leu Arg Pro Lys Tyr Lys Val Gly Tyr Lys Thr 
            100                 105                 110         


Val Thr Asp Leu Ala Trp Arg Cys Cys Pro Gly Phe Thr Gly Lys Arg 
        115                 120                 125             


Cys Pro Glu His Leu Thr Asp His Gly Ala Ala Ser Pro Gln Leu Glu 
    130                 135                 140                 


Pro Glu Pro Gln Ile Pro Ser Gly Gln Leu Asp Pro Gly Pro Arg Pro 
145                 150                 155                 160 


Pro Ser Tyr Ser Arg Ala Ala Pro Ser Pro His Gly Arg Lys Gly Pro 
                165                 170                 175     


Gly Leu Phe Gly Glu Arg Leu Glu Arg Leu Glu Gly Asp Val Gln Arg 
            180                 185                 190         


Leu Ala Gln Thr Tyr Gly Thr Leu Ser Gly Leu Val Ala Ser His Glu 
        195                 200                 205             


Asp Pro Asn Arg Met Thr Gly Gly Pro Arg Ala Pro Ala Val Pro Val 
    210                 215                 220                 


Gly Phe Gly Val Ile Pro Glu Gly Leu Val Gly Pro Gly Asp Arg Ala 
225                 230                 235                 240 


Arg Gly Pro Leu Thr Pro Pro Leu Asp Glu Ile Leu Ser Lys Val Thr 
                245                 250                 255     


Glu Val Ser Asn Thr Leu Gln Thr Lys Val Gln Leu Leu Asp Lys Val 
            260                 265                 270         


His Gly Leu Ala Leu Gly His Glu Ala His Leu Gln Arg Leu Arg Glu 
        275                 280                 285             


Ala Pro Pro Ser Pro Leu Thr Ser Leu Ala Leu Leu Glu Glu Tyr Val 
    290                 295                 300                 


Asp Arg Arg Leu His Arg Leu Trp Gly Ser Leu Leu Asp Gly Phe Glu 
305                 310                 315                 320 


Gln Lys Leu Gln Gly Val Gln Ser Glu Cys Asp Leu Arg Val Gln Glu 
                325                 330                 335     


Val Arg Arg Gln Cys Glu Glu Gly Gln Ala Ala Ser Arg Arg Leu His 
            340                 345                 350         


Gln Ser Leu Asp Gly Arg Glu Leu Ala Leu Arg Gln Glu Leu Ser Gln 
        355                 360                 365             


Leu Gly Ser Gln Leu Gln Gly Leu Ser Val Ser Gly Arg Gly Ser Cys 
    370                 375                 380                 


Cys Gly Gln Leu Ala Leu Ile Asn Ala Arg Met Asp Gly Leu Glu Arg 
385                 390                 395                 400 


Ala Leu Gln Ala Val Thr Glu Thr Gln Arg Gly Pro Gly Ala Pro Ala 
                405                 410                 415     


Gly Asp Glu Leu Thr Arg Leu Ser Ala Ala Met Leu Glu Gly Gly Val 
            420                 425                 430         


Asp Gly Leu Leu Glu Gly Leu Glu Thr Leu Asn Gly Thr Glu Gly Gly 
        435                 440                 445             


Ala Arg Gly Cys Cys Leu Arg Leu Asp Met Gly Gly Trp Gly Val Gly 
    450                 455                 460                 


Gly Phe Gly Thr Met Leu Glu Glu Arg Val Gln Ser Leu Glu Glu Arg 
465                 470                 475                 480 


Leu Ala Thr Leu Ala Gly Glu Leu Ser His Asp Ser Ala Ser Pro Gly 
                485                 490                 495     


Arg Ser Ala Arg Pro Leu Val Gln Thr Glu Leu Ala Val Leu Glu Gln 
            500                 505                 510         


Arg Leu Val Ser Leu Glu Thr Ser Cys Thr Pro Ser Thr Thr Ser Ala 
        515                 520                 525             


Ile Leu Asp Ser Leu Val Ala Glu Val Lys Ala Trp Gln Ser Arg Ser 
    530                 535                 540                 


Glu Ala Leu Leu Arg Gln Val Ala Ser His Ala Ala Leu Leu Gln Gln 
545                 550                 555                 560 


Leu Asn Gly Thr Val Ala Glu Val Gln Gly Gln Leu Ala Glu Gly Thr 
                565                 570                 575     


Gly Ser Ser Leu Gln Gly Glu Ile Thr Leu Leu Lys Val Asn Leu Asn 
            580                 585                 590         


Ser Val Ser Lys Ser Leu Thr Gly Leu Ser Asp Ser Val Ser Gln Tyr 
        595                 600                 605             


Ser Asp Ala Phe Leu Ala Ala Asn Thr Ser Leu Asp Glu Arg Glu Arg 
    610                 615                 620                 


Lys Val Glu Ala Glu Val Gln Ala Ile Gln Glu Gln Val Ser Ser Gln 
625                 630                 635                 640 


Gly Ser Arg Leu Gln Ala Gly His Arg Gln Val Leu Asn Leu Arg Gly 
                645                 650                 655     


Glu Leu Glu Gln Leu Lys Ala Gly Val Ala Lys Val Ala Ser Gly Leu 
            660                 665                 670         


Ser Arg Cys Gln Asp Thr Ala Gln Lys Leu Gln His Thr Val Gly His 
        675                 680                 685             


Phe Asp Gln Arg Val Ala Gln Val Glu Gly Ala Cys Arg Arg Leu Gly 
    690                 695                 700                 


Leu Leu Ala Ala Gly Leu Asp Ser Leu Pro Thr Glu Pro Leu Arg Pro 
705                 710                 715                 720 


Arg Glu Gly Leu Trp Ser His Val Asp Gln Leu Asn Arg Thr Leu Ala 
                725                 730                 735     


Gln His Thr Gln Asp Ile Ala Arg Leu Arg Asp Asp Leu Leu Asp Cys 
            740                 745                 750         


Gln Ala Gln Leu Ala Glu Gln Val Arg Pro Gly Gln Ala Asn 
        755                 760                 765     


<210>  3538
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EML1__Homo_sapiens__NP_001008707

<400>  3538

Met Glu Asp Gly Phe Ser Ser Tyr Ser Ser Leu Tyr Asp Thr Ser Ser 
1               5                   10                  15      


Leu Leu Gln Phe Cys Asn Asp Asp Ser Ala Ser Ala Ala Ser Ser Met 
            20                  25                  30          


Glu Val Thr Asp Arg Ile Ala Ser Leu Glu Gln Arg Val Gln Met Gln 
        35                  40                  45              


Glu Asp Asp Ile Gln Leu Leu Lys Ser Ala Leu Ala Asp Val Val Arg 
    50                  55                  60                  


Arg Leu Asn Ile Thr Glu Glu Gln Gln Ala Val Leu Asn Arg Lys Gly 
65                  70                  75                  80  


Pro Thr Lys Ala Arg Pro Leu Met Gln Thr Leu Pro Leu Arg Thr Thr 
                85                  90                  95      


Val Asn Asn Gly Thr Val Leu Pro Lys Lys Pro Thr Gly Ser Leu Pro 
            100                 105                 110         


Ser Pro Ser Gly Val Arg Lys Glu Thr Ala Val Pro Ala Thr Lys Arg 
        115                 120                 125             


Leu Asn Arg Ser Val Ser Leu Leu Asn Ala Cys Lys Leu Asn Arg Ser 
    130                 135                 140                 


Thr Pro Ser Asn Ile Lys Arg Thr Ser Ser Ser Glu Arg Val Ser Pro 
145                 150                 155                 160 


Gly Gly Arg Arg Glu Ser Asn Gly Asp Ser Arg Gly Asn Arg Asn Arg 
                165                 170                 175     


Thr Gly Ser Thr Ser Ser Ser Ser Ser Gly Lys Lys Asn Ser Glu Ser 
            180                 185                 190         


Lys Pro Lys Glu Pro Val Phe Ser Ala Glu Glu Gly Tyr Val Lys Met 
        195                 200                 205             


Phe Leu Arg Gly Arg Pro Val Thr Met Tyr Met Pro Lys Asp Gln Val 
    210                 215                 220                 


Asp Ser Tyr Ser Leu Glu Ala Lys Val Glu Leu Pro Thr Lys Arg Leu 
225                 230                 235                 240 


Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Asn Asn 
                245                 250                 255     


Leu Tyr Leu Leu Pro Thr Gly Glu Thr Val Tyr Phe Ile Ala Ser Val 
            260                 265                 270         


Val Val Leu Tyr Asn Val Glu Glu Gln Leu Gln Arg His Tyr Ala Gly 
        275                 280                 285             


His Asn Asp Asp Val Lys Cys Leu Ala Val His Pro Asp Arg Ile Thr 
    290                 295                 300                 


Ile Ala Thr Gly Gln Val Ala Gly Thr Ser Lys Asp Gly Lys Gln Leu 
305                 310                 315                 320 


Pro Pro His Val Arg Ile Trp Asp Ser Val Thr Leu Asn Thr Leu His 
                325                 330                 335     


Val Ile Gly Ile Gly Phe Phe Asp Arg Ala Val Thr Cys Ile Ala Phe 
            340                 345                 350         


Ser Lys Ser Asn Gly Gly Thr Asn Leu Cys Ala Val Asp Asp Ser Asn 
        355                 360                 365             


Asp His Val Leu Ser Val Trp Asp Trp Gln Lys Glu Glu Lys Leu Ala 
    370                 375                 380                 


Asp Val Lys Cys Ser Asn Glu Ala Val Phe Ala Ala Asp Phe His Pro 
385                 390                 395                 400 


Thr Asp Thr Asn Ile Ile Val Thr Cys Gly Lys Ser His Leu Tyr Phe 
                405                 410                 415     


Trp Thr Leu Glu Gly Ser Ser Leu Asn Lys Lys Gln Gly Leu Phe Glu 
            420                 425                 430         


Lys Gln Glu Lys Pro Lys Phe Val Leu Cys Val Thr Phe Ser Glu Asn 
        435                 440                 445             


Gly Asp Thr Ile Thr Gly Asp Ser Ser Gly Asn Ile Leu Val Trp Gly 
    450                 455                 460                 


Lys Gly Thr Asn Arg Ile Ser Tyr Ala Val Gln Gly Ala His Glu Gly 
465                 470                 475                 480 


Gly Ile Phe Ala Leu Cys Met Leu Arg Asp Gly Thr Leu Val Ser Gly 
                485                 490                 495     


Gly Gly Lys Asp Arg Lys Leu Ile Ser Trp Ser Gly Asn Tyr Gln Lys 
            500                 505                 510         


Leu Arg Lys Thr Glu Ile Pro Glu Gln Phe Gly Pro Ile Arg Thr Val 
        515                 520                 525             


Ala Glu Gly Lys Gly Asp Val Ile Leu Ile Gly Thr Thr Arg Asn Phe 
    530                 535                 540                 


Val Leu Gln Gly Thr Leu Ser Gly Asp Phe Thr Pro Ile Thr Gln Gly 
545                 550                 555                 560 


His Thr Asp Glu Leu Trp Gly Leu Ala Ile His Ala Ser Lys Ser Gln 
                565                 570                 575     


Phe Leu Thr Cys Gly His Asp Lys His Ala Thr Leu Trp Asp Ala Val 
            580                 585                 590         


Gly His Arg Pro Val Trp Asp Lys Ile Ile Glu Asp Pro Ala Gln Ser 
        595                 600                 605             


Ser Gly Phe His Pro Ser Gly Ser Val Val Ala Val Gly Thr Leu Thr 
    610                 615                 620                 


Gly Arg Trp Phe Val Phe Asp Thr Glu Thr Lys Asp Leu Val Thr Val 
625                 630                 635                 640 


His Thr Asp Gly Asn Glu Gln Leu Ser Val Met Arg Tyr Ser Pro Asp 
                645                 650                 655     


Gly Asn Phe Leu Ala Ile Gly Ser His Asp Asn Cys Ile Tyr Ile Tyr 
            660                 665                 670         


Gly Val Ser Asp Asn Gly Arg Lys Tyr Thr Arg Val Gly Lys Cys Ser 
        675                 680                 685             


Gly His Ser Ser Phe Ile Thr His Leu Asp Trp Ser Val Asn Ser Gln 
    690                 695                 700                 


Phe Leu Val Ser Asn Ser Gly Asp Tyr Glu Ile Leu Tyr Trp Val Pro 
705                 710                 715                 720 


Ser Ala Cys Lys Gln Val Val Ser Val Glu Thr Thr Arg Asp Ile Glu 
                725                 730                 735     


Trp Ala Thr Tyr Thr Cys Thr Leu Gly Phe His Val Phe Gly Val Trp 
            740                 745                 750         


Pro Glu Gly Ser Asp Gly Thr Asp Ile Asn Ala Val Cys Arg Ala His 
        755                 760                 765             


Glu Lys Lys Leu Leu Ser Thr Gly Asp Asp Phe Gly Lys Val His Leu 
    770                 775                 780                 


Phe Ser Tyr Pro Cys Ser Gln Phe Arg Ala Pro Ser His Ile Tyr Gly 
785                 790                 795                 800 


Gly His Ser Ser His Val Thr Asn Val Asp Phe Leu Cys Glu Asp Ser 
                805                 810                 815     


His Leu Ile Ser Thr Gly Gly Lys Asp Thr Ser Ile Met Gln Trp Arg 
            820                 825                 830         


Val Ile 
        


<210>  3539
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EML2__Homo_sapiens__NP_001180197

<400>  3539

Met Leu Glu Arg Arg Ala Leu Leu Trp Gln Arg Glu Ala Gly Pro Gly 
1               5                   10                  15      


Trp Gly Asp Arg Ala Arg Ala Gly Thr Gly Gly Ala Gly Gly Gly Cys 
            20                  25                  30          


Gly Gly Ala Met Ala Glu Arg Gly Pro Ala Phe Cys Gly Leu Tyr Asp 
        35                  40                  45              


Thr Ser Ser Leu Leu Arg Tyr Cys Asn Asp Asp Asn Leu Ser Gly Thr 
    50                  55                  60                  


Ser Gly Met Glu Val Asp Asp Arg Val Ser Ala Leu Glu Gln Arg Leu 
65                  70                  75                  80  


Gln Leu Gln Glu Asp Glu Leu Ala Val Leu Lys Ala Ala Leu Ala Asp 
                85                  90                  95      


Ala Leu Arg Arg Leu Arg Ala Cys Glu Glu Gln Gly Ala Ala Leu Arg 
            100                 105                 110         


Ala Arg Gly Thr Pro Lys Gly Arg Ala Pro Pro Arg Leu Gly Thr Thr 
        115                 120                 125             


Ala Ser Val Cys Gln Leu Leu Lys Gly Leu Pro Thr Arg Thr Pro Leu 
    130                 135                 140                 


Asn Gly Ser Gly Pro Pro Arg Arg Val Gly Gly Tyr Ala Thr Ser Pro 
145                 150                 155                 160 


Ser Ser Pro Lys Lys Glu Ala Thr Ser Gly Arg Ser Ser Val Arg Arg 
                165                 170                 175     


Tyr Leu Ser Pro Glu Arg Leu Ala Ser Val Arg Arg Glu Asp Pro Arg 
            180                 185                 190         


Ser Arg Thr Thr Ser Ser Ser Ser Asn Cys Ser Ala Lys Lys Glu Gly 
        195                 200                 205             


Lys Thr Lys Glu Val Ile Phe Ser Val Glu Asp Gly Ser Val Lys Met 
    210                 215                 220                 


Phe Leu Arg Gly Arg Pro Val Pro Met Met Ile Pro Asp Glu Leu Ala 
225                 230                 235                 240 


Pro Thr Tyr Ser Leu Asp Thr Arg Ser Glu Leu Pro Ser Cys Arg Leu 
                245                 250                 255     


Lys Leu Glu Trp Val Tyr Gly Tyr Arg Gly Arg Asp Cys Arg Ala Asn 
            260                 265                 270         


Leu Tyr Leu Leu Pro Thr Gly Glu Ile Val Tyr Phe Val Ala Ser Val 
        275                 280                 285             


Ala Val Leu Tyr Ser Val Glu Glu Gln Arg Gln Arg His Tyr Leu Gly 
    290                 295                 300                 


His Asn Asp Asp Ile Lys Cys Leu Ala Ile His Pro Asp Met Val Thr 
305                 310                 315                 320 


Ile Ala Thr Gly Gln Val Ala Gly Thr Thr Lys Glu Gly Lys Pro Leu 
                325                 330                 335     


Pro Pro His Val Arg Ile Trp Asp Ser Val Ser Leu Ser Thr Leu His 
            340                 345                 350         


Val Leu Gly Leu Gly Val Phe Asp Arg Ala Val Cys Cys Val Gly Phe 
        355                 360                 365             


Ser Lys Ser Asn Gly Gly Asn Leu Leu Cys Ala Val Asp Glu Ser Asn 
    370                 375                 380                 


Asp His Met Leu Ser Val Trp Asp Trp Ala Lys Glu Thr Lys Val Val 
385                 390                 395                 400 


Asp Val Lys Cys Ser Asn Glu Ala Val Leu Val Ala Thr Phe His Pro 
                405                 410                 415     


Thr Asp Pro Thr Val Leu Ile Thr Cys Gly Lys Ser His Ile Tyr Phe 
            420                 425                 430         


Trp Thr Leu Glu Gly Gly Ser Leu Ser Lys Arg Gln Gly Leu Phe Glu 
        435                 440                 445             


Lys His Glu Lys Pro Lys Tyr Val Leu Cys Val Thr Phe Leu Glu Gly 
    450                 455                 460                 


Gly Asp Val Val Thr Gly Asp Ser Gly Gly Asn Leu Tyr Val Trp Gly 
465                 470                 475                 480 


Lys Gly Gly Asn Arg Ile Thr Gln Ala Val Leu Gly Ala His Asp Gly 
                485                 490                 495     


Gly Val Phe Gly Leu Cys Ala Leu Arg Asp Gly Thr Leu Val Ser Gly 
            500                 505                 510         


Gly Gly Arg Asp Arg Arg Val Val Leu Trp Gly Ser Asp Tyr Ser Lys 
        515                 520                 525             


Leu Gln Glu Val Glu Val Pro Glu Asp Phe Gly Pro Val Arg Thr Val 
    530                 535                 540                 


Ala Glu Gly His Gly Asp Thr Leu Tyr Val Gly Thr Thr Arg Asn Ser 
545                 550                 555                 560 


Ile Leu Gln Gly Ser Val His Thr Gly Phe Ser Leu Leu Val Gln Gly 
                565                 570                 575     


His Val Glu Glu Leu Trp Gly Leu Ala Thr His Pro Ser Arg Ala Gln 
            580                 585                 590         


Phe Val Thr Cys Gly Gln Asp Lys Leu Val His Leu Trp Ser Ser Asp 
        595                 600                 605             


Ser His Gln Pro Leu Trp Ser Arg Ile Ile Glu Asp Pro Ala Arg Ser 
    610                 615                 620                 


Ala Gly Phe His Pro Ser Gly Ser Val Leu Ala Val Gly Thr Val Thr 
625                 630                 635                 640 


Gly Arg Trp Leu Leu Leu Asp Thr Glu Thr His Asp Leu Val Ala Ile 
                645                 650                 655     


His Thr Asp Gly Asn Glu Gln Ile Ser Val Val Ser Phe Ser Pro Asp 
            660                 665                 670         


Gly Ala Tyr Leu Ala Val Gly Ser His Asp Asn Leu Val Tyr Val Tyr 
        675                 680                 685             


Thr Val Asp Gln Gly Gly Arg Lys Val Ser Arg Leu Gly Lys Cys Ser 
    690                 695                 700                 


Gly His Ser Ser Phe Ile Thr His Leu Asp Trp Ala Gln Asp Ser Ser 
705                 710                 715                 720 


Cys Phe Val Thr Asn Ser Gly Asp Tyr Glu Ile Leu Tyr Trp Asp Pro 
                725                 730                 735     


Ala Thr Cys Lys Gln Ile Thr Ser Ala Asp Ala Val Arg Asn Met Glu 
            740                 745                 750         


Trp Ala Thr Ala Thr Cys Val Leu Gly Phe Gly Val Phe Gly Ile Trp 
        755                 760                 765             


Ser Glu Gly Ala Asp Gly Thr Asp Ile Asn Ala Val Ala Arg Ser His 
    770                 775                 780                 


Asp Gly Lys Leu Leu Ala Ser Ala Asp Asp Phe Gly Lys Val His Leu 
785                 790                 795                 800 


Phe Ser Tyr Pro Cys Cys Gln Pro Arg Ala Leu Ser His Lys Tyr Gly 
                805                 810                 815     


Gly His Ser Ser His Val Thr Asn Val Ala Phe Leu Trp Asp Asp Ser 
            820                 825                 830         


Met Ala Leu Thr Thr Gly Gly Lys Asp Thr Ser Val Leu Gln Trp Arg 
        835                 840                 845             


Val Val 
    850 


<210>  3540
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EML4__Homo_sapiens__NP_001138548

<400>  3540

Met Asp Gly Phe Ala Gly Ser Leu Asp Asp Ser Ile Ser Ala Ala Ser 
1               5                   10                  15      


Thr Ser Asp Val Gln Asp Arg Leu Ser Ala Leu Glu Ser Arg Val Gln 
            20                  25                  30          


Gln Gln Glu Asp Glu Ile Thr Val Leu Lys Ala Ala Leu Ala Asp Val 
        35                  40                  45              


Leu Arg Arg Leu Ala Ile Ser Glu Asp His Val Ala Ser Val Lys Lys 
    50                  55                  60                  


Ser Val Ser Ser Lys Gly Gln Pro Ser Pro Arg Ala Val Ile Pro Met 
65                  70                  75                  80  


Ser Cys Ile Thr Asn Gly Ser Gly Ala Asn Arg Lys Pro Ser His Thr 
                85                  90                  95      


Ser Ala Val Ser Ile Ala Gly Lys Glu Thr Leu Ser Ser Ala Ala Lys 
            100                 105                 110         


Ser Ile Lys Arg Pro Ser Pro Ala Glu Lys Ser His Asn Ser Trp Glu 
        115                 120                 125             


Asn Ser Asp Asp Ser Arg Asn Lys Leu Ser Lys Ile Pro Ser Thr Pro 
    130                 135                 140                 


Lys Leu Ile Pro Lys Val Thr Lys Thr Ala Asp Lys His Lys Asp Val 
145                 150                 155                 160 


Ile Ile Asn Gln Glu Gly Glu Tyr Ile Lys Met Phe Met Arg Gly Arg 
                165                 170                 175     


Pro Ile Thr Met Phe Ile Pro Ser Asp Val Asp Asn Tyr Asp Asp Ile 
            180                 185                 190         


Arg Thr Glu Leu Pro Pro Glu Lys Leu Lys Leu Glu Trp Ala Tyr Gly 
        195                 200                 205             


Tyr Arg Gly Lys Asp Cys Arg Ala Asn Val Tyr Leu Leu Pro Thr Gly 
    210                 215                 220                 


Glu Ile Val Tyr Phe Ile Ala Ser Val Val Val Leu Phe Asn Tyr Glu 
225                 230                 235                 240 


Glu Arg Thr Gln Arg His Tyr Leu Gly His Thr Asp Cys Val Lys Cys 
                245                 250                 255     


Leu Ala Ile His Pro Asp Lys Ile Arg Ile Ala Thr Gly Gln Ile Ala 
            260                 265                 270         


Gly Val Asp Lys Asp Gly Arg Pro Leu Gln Pro His Val Arg Val Trp 
        275                 280                 285             


Asp Ser Val Thr Leu Ser Thr Leu Gln Ile Ile Gly Leu Gly Thr Phe 
    290                 295                 300                 


Glu Arg Gly Val Gly Cys Leu Asp Phe Ser Lys Ala Asp Ser Gly Val 
305                 310                 315                 320 


His Leu Cys Val Ile Asp Asp Ser Asn Glu His Met Leu Thr Val Trp 
                325                 330                 335     


Asp Trp Gln Lys Lys Ala Lys Gly Ala Glu Ile Lys Thr Thr Asn Glu 
            340                 345                 350         


Val Val Leu Ala Val Glu Phe His Pro Thr Asp Ala Asn Thr Ile Ile 
        355                 360                 365             


Thr Cys Gly Lys Ser His Ile Phe Phe Trp Thr Trp Ser Gly Asn Ser 
    370                 375                 380                 


Leu Thr Arg Lys Gln Gly Ile Phe Gly Lys Tyr Glu Lys Pro Lys Phe 
385                 390                 395                 400 


Val Gln Cys Leu Ala Phe Leu Gly Asn Gly Asp Val Leu Thr Gly Asp 
                405                 410                 415     


Ser Gly Gly Val Met Leu Ile Trp Ser Lys Thr Thr Val Glu Pro Thr 
            420                 425                 430         


Pro Gly Lys Gly Pro Lys Gly Val Tyr Gln Ile Ser Lys Gln Ile Lys 
        435                 440                 445             


Ala His Asp Gly Ser Val Phe Thr Leu Cys Gln Met Arg Asn Gly Met 
    450                 455                 460                 


Leu Leu Thr Gly Gly Gly Lys Asp Arg Lys Ile Ile Leu Trp Asp His 
465                 470                 475                 480 


Asp Leu Asn Pro Glu Arg Glu Ile Glu Val Pro Asp Gln Tyr Gly Thr 
                485                 490                 495     


Ile Arg Ala Val Ala Glu Gly Lys Ala Asp Gln Phe Leu Val Gly Thr 
            500                 505                 510         


Ser Arg Asn Phe Ile Leu Arg Gly Thr Phe Asn Asp Gly Phe Gln Ile 
        515                 520                 525             


Glu Val Gln Gly His Thr Asp Glu Leu Trp Gly Leu Ala Thr His Pro 
    530                 535                 540                 


Phe Lys Asp Leu Leu Leu Thr Cys Ala Gln Asp Arg Gln Val Cys Leu 
545                 550                 555                 560 


Trp Asn Ser Met Glu His Arg Leu Glu Trp Thr Arg Leu Val Asp Glu 
                565                 570                 575     


Pro Gly His Cys Ala Asp Phe His Pro Ser Gly Thr Val Val Ala Ile 
            580                 585                 590         


Gly Thr His Ser Gly Arg Trp Phe Val Leu Asp Ala Glu Thr Arg Asp 
        595                 600                 605             


Leu Val Ser Ile His Thr Asp Gly Asn Glu Gln Leu Ser Val Met Arg 
    610                 615                 620                 


Tyr Ser Ile Asp Gly Thr Phe Leu Ala Val Gly Ser His Asp Asn Phe 
625                 630                 635                 640 


Ile Tyr Leu Tyr Val Val Ser Glu Asn Gly Arg Lys Tyr Ser Arg Tyr 
                645                 650                 655     


Gly Arg Cys Thr Gly His Ser Ser Tyr Ile Thr His Leu Asp Trp Ser 
            660                 665                 670         


Pro Asp Asn Lys Tyr Ile Met Ser Asn Ser Gly Asp Tyr Glu Ile Leu 
        675                 680                 685             


Tyr Trp Asp Ile Pro Asn Gly Cys Lys Leu Ile Arg Asn Arg Ser Asp 
    690                 695                 700                 


Cys Lys Asp Ile Asp Trp Thr Thr Tyr Thr Cys Val Leu Gly Phe Gln 
705                 710                 715                 720 


Val Phe Gly Val Trp Pro Glu Gly Ser Asp Gly Thr Asp Ile Asn Ala 
                725                 730                 735     


Leu Val Arg Ser His Asn Arg Lys Val Ile Ala Val Ala Asp Asp Phe 
            740                 745                 750         


Cys Lys Val His Leu Phe Gln Tyr Pro Cys Ser Lys Ala Lys Ala Pro 
        755                 760                 765             


Ser His Lys Tyr Ser Ala His Ser Ser His Val Thr Asn Val Ser Phe 
    770                 775                 780                 


Thr His Asn Asp Ser His Leu Ile Ser Thr Gly Gly Lys Asp Met Ser 
785                 790                 795                 800 


Ile Ile Gln Trp Lys Leu Val Glu Lys Leu Ser Leu Pro Gln Asn Glu 
                805                 810                 815     


Thr Val Ala Asp Thr Thr Leu Thr Lys Ala Pro Val Ser Ser Thr Glu 
            820                 825                 830         


Ser Val Ile Gln Ser Asn Thr Pro Thr Pro Pro Pro Ser Gln Pro Leu 
        835                 840                 845             


Asn Glu Thr Ala Glu Glu Glu Ser Arg Ile Ser Ser Ser Pro Thr Leu 
    850                 855                 860                 


Leu Glu Asn Ser Leu Glu Gln Thr Val Glu Pro Ser Glu Asp His Ser 
865                 870                 875                 880 


Glu Glu Glu Ser Glu Glu Gly Ser Gly Asp Leu Gly Glu Pro Leu Tyr 
                885                 890                 895     


Glu Glu Pro Cys Asn Glu Ile Ser Lys Glu Gln Ala Lys Ala Thr Leu 
            900                 905                 910         


Leu Glu Asp Gln Gln Asp Pro Ser Pro Ser Ser 
        915                 920             


<210>  3541
<211>  1977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EML5__Homo_sapiens__NP_899243

<400>  3541

Met Ala Ala Arg Ser Ala Pro Ser Cys His Leu Arg Leu Glu Trp Val 
1               5                   10                  15      


Tyr Gly Tyr Arg Gly His Gln Cys Arg Asn Asn Leu Tyr Tyr Thr Ala 
            20                  25                  30          


Ala Lys Glu Ile Val Tyr Phe Val Ala Gly Val Gly Val Val Tyr Ser 
        35                  40                  45              


Pro Arg Glu His Arg Gln Lys Phe Tyr Arg Gly His Ser Asp Asp Ile 
    50                  55                  60                  


Ile Ser Leu Ala Leu His Pro Glu Arg Val Leu Val Ala Thr Gly Gln 
65                  70                  75                  80  


Val Gly Lys Glu Pro Tyr Ile Cys Ile Trp Asp Ser Tyr Thr Val Gln 
                85                  90                  95      


Thr Ile Ser Val Leu Lys Asp Val His Thr His Gly Ile Ala Cys Leu 
            100                 105                 110         


Ala Phe Asp Leu Asp Gly Gln Arg Leu Val Ser Val Gly Leu Asp Ser 
        115                 120                 125             


Lys Asn Ala Val Cys Val Trp Asp Trp Lys Arg Gly Lys Met Leu Ser 
    130                 135                 140                 


Met Ala Pro Gly His Thr Asp Arg Ile Phe Asp Ile Ser Trp Asp Leu 
145                 150                 155                 160 


Tyr Gln Pro Asn Lys Leu Val Ser Cys Gly Val Lys His Ile Lys Phe 
                165                 170                 175     


Trp Ser Leu Cys Gly Asn Ala Leu Thr Pro Lys Arg Gly Val Phe Gly 
            180                 185                 190         


Lys Thr Gly Asp Leu Gln Thr Ile Leu Cys Leu Ala Cys Ala Arg Asp 
        195                 200                 205             


Glu Leu Thr Tyr Ser Gly Ala Leu Asn Gly Asp Ile Tyr Val Trp Lys 
    210                 215                 220                 


Gly Ile Asn Leu Ile Arg Thr Ile Gln Gly Ala His Ala Ala Gly Ile 
225                 230                 235                 240 


Phe Ser Met Asn Ala Cys Glu Glu Gly Phe Ala Thr Gly Gly Arg Asp 
                245                 250                 255     


Gly Cys Ile Arg Leu Trp Asp Leu Thr Phe Lys Pro Ile Thr Val Ile 
            260                 265                 270         


Asp Leu Arg Glu Thr Asp Gln Gly Tyr Lys Gly Leu Ser Val Arg Ser 
        275                 280                 285             


Val Cys Trp Arg Gly Asp His Ile Leu Val Gly Thr Gln Asp Ser Glu 
    290                 295                 300                 


Ile Phe Glu Ile Val Val Gln Glu Arg Asn Lys Pro Phe Leu Ile Met 
305                 310                 315                 320 


Gln Gly His Cys Glu Gly Glu Leu Trp Ala Leu Ala Val His Pro Thr 
                325                 330                 335     


Lys Pro Leu Ala Val Thr Gly Ser Asp Asp Arg Ser Val Arg Ile Trp 
            340                 345                 350         


Ser Leu Val Asp His Ala Leu Ile Ala Arg Cys Asn Met Glu Glu Pro 
        355                 360                 365             


Ile Arg Cys Ala Ala Val Asn Ala Asp Gly Ile His Leu Ala Leu Gly 
    370                 375                 380                 


Met Lys Asp Gly Ser Phe Thr Val Leu Arg Val Arg Asp Met Thr Glu 
385                 390                 395                 400 


Val Val His Ile Lys Asp Arg Lys Glu Ala Ile His Glu Leu Lys Tyr 
                405                 410                 415     


Ser Pro Asp Gly Thr Tyr Leu Ala Val Gly Cys Asn Asp Ser Ser Val 
            420                 425                 430         


Asp Ile Tyr Gly Val Ala Gln Arg Tyr Lys Lys Val Gly Glu Cys Leu 
        435                 440                 445             


Gly Ser Leu Ser Phe Ile Thr His Leu Asp Trp Ser Ser Asp Ser Arg 
    450                 455                 460                 


Tyr Leu Gln Thr Asn Asp Gly Asn Gly Lys Arg Leu Phe Tyr Arg Met 
465                 470                 475                 480 


Pro Gly Gly Lys Glu Val Thr Ser Thr Glu Glu Ile Lys Gly Val His 
                485                 490                 495     


Trp Ala Ser Trp Thr Cys Val Ser Gly Leu Glu Val Asn Gly Ile Trp 
            500                 505                 510         


Pro Lys Tyr Ser Asp Ile Asn Asp Ile Asn Ser Val Asp Gly Asn Tyr 
        515                 520                 525             


Ile Gly Gln Val Leu Val Thr Ala Asp Asp Tyr Gly Ile Ile Lys Leu 
    530                 535                 540                 


Phe Arg Tyr Pro Cys Leu Arg Lys Gly Ala Lys Phe Arg Lys Tyr Ile 
545                 550                 555                 560 


Gly His Ser Ala His Val Thr Asn Val Arg Trp Ser His Asp Tyr Gln 
                565                 570                 575     


Trp Val Ile Ser Ile Gly Gly Ala Asp His Ser Val Phe Gln Trp Lys 
            580                 585                 590         


Phe Ile Pro Glu Arg Lys Leu Lys Asp Ala Val His Ile Ala Pro Gln 
        595                 600                 605             


Glu Ser Leu Ala Asp Ser His Ser Asp Glu Ser Asp Ser Asp Leu Ser 
    610                 615                 620                 


Asp Val Pro Glu Leu Asp Ser Glu Ile Glu Gln Glu Thr Gln Leu Thr 
625                 630                 635                 640 


Tyr Arg Arg Gln Val Tyr Lys Glu Asp Leu Pro Gln Leu Lys Glu Gln 
                645                 650                 655     


Cys Lys Glu Lys Gln Lys Ser Ala Thr Ser Lys Arg Arg Glu Arg Ala 
            660                 665                 670         


Pro Gly Asn Ser Ile Arg Leu His Phe Val His Gly Tyr Arg Gly Tyr 
        675                 680                 685             


Asp Cys Arg Ser Asn Leu Phe Tyr Thr Gln Ile Gly Glu Ile Val Tyr 
    690                 695                 700                 


His Val Ala Ala Val Gly Val Ile Tyr Asn Arg Gln Gln Asn Thr Gln 
705                 710                 715                 720 


Arg Phe Tyr Leu Gly His Asp Asp Asp Ile Leu Cys Leu Thr Ile His 
                725                 730                 735     


Pro Leu Lys Asp Tyr Val Ala Thr Gly Gln Val Gly Arg Asp Pro Ser 
            740                 745                 750         


Ile His Ile Trp Asp Thr Glu Thr Ile Lys Pro Leu Ser Ile Leu Lys 
        755                 760                 765             


Gly His His Gln Tyr Gly Val Ser Ala Val Asp Phe Ser Ala Asp Gly 
    770                 775                 780                 


Lys Arg Leu Ala Ser Val Gly Ile Asp Asp Ser His Thr Val Val Leu 
785                 790                 795                 800 


Trp Asp Trp Lys Lys Gly Glu Lys Leu Ser Ile Ala Arg Gly Ser Lys 
                805                 810                 815     


Asp Lys Ile Phe Val Val Lys Met Asn Pro Tyr Val Pro Asp Lys Leu 
            820                 825                 830         


Ile Thr Ala Gly Ile Lys His Met Lys Phe Trp Arg Lys Ala Gly Gly 
        835                 840                 845             


Gly Leu Ile Gly Arg Lys Gly Tyr Ile Gly Thr Leu Gly Lys Asn Asp 
    850                 855                 860                 


Thr Met Met Cys Ala Val Tyr Gly Trp Thr Glu Glu Met Ala Phe Ser 
865                 870                 875                 880 


Gly Thr Ser Thr Gly Asp Val Cys Ile Trp Arg Asp Ile Phe Leu Val 
                885                 890                 895     


Lys Thr Val Lys Ala His Asp Gly Pro Val Phe Ser Met His Ala Leu 
            900                 905                 910         


Glu Lys Gly Phe Val Thr Gly Gly Lys Asp Gly Ile Val Ala Leu Trp 
        915                 920                 925             


Asp Asp Ser Phe Glu Arg Cys Leu Lys Thr Tyr Ala Ile Lys Arg Ala 
    930                 935                 940                 


Ala Leu Ala Pro Gly Ser Lys Gly Leu Leu Leu Glu Asp Asn Pro Ser 
945                 950                 955                 960 


Ile Arg Ala Ile Ser Leu Gly His Gly His Ile Leu Val Gly Thr Lys 
                965                 970                 975     


Asn Gly Glu Ile Leu Glu Val Asp Lys Ser Gly Pro Ile Thr Leu Leu 
            980                 985                 990         


Val Gln Gly His Met Glu Gly Glu  Val Trp Gly Leu Ala  Thr His Pro 
        995                 1000                 1005             


Tyr Leu  Pro Ile Cys Ala Thr  Val Ser Asp Asp Lys  Thr Leu Arg 
    1010                 1015                 1020             


Ile Trp  Asp Leu Ser Pro Ser  His Cys Met Leu Ala  Val Arg Lys 
    1025                 1030                 1035             


Leu Lys  Lys Gly Gly Arg Cys  Cys Cys Phe Ser Pro  Asp Gly Lys 
    1040                 1045                 1050             


Ala Leu  Ala Val Gly Leu Asn  Asp Gly Ser Phe Leu  Met Ala Asn 
    1055                 1060                 1065             


Ala Asp  Thr Leu Glu Asp Leu  Val Ser Phe His His  Arg Lys Asp 
    1070                 1075                 1080             


Met Ile  Ser Asp Ile Arg Phe  Ser Pro Gly Ser Gly  Lys Tyr Leu 
    1085                 1090                 1095             


Ala Val  Ala Ser His Asp Ser  Phe Ile Asp Ile Tyr  Asn Val Met 
    1100                 1105                 1110             


Ser Ser  Lys Arg Val Gly Ile  Cys Lys Gly Ala Thr  Ser Tyr Ile 
    1115                 1120                 1125             


Thr His  Ile Asp Trp Asp Ile  Arg Gly Lys Leu Leu  Gln Val Asn 
    1130                 1135                 1140             


Thr Gly  Ala Lys Glu Gln Leu  Phe Phe Glu Ala Pro  Arg Gly Lys 
    1145                 1150                 1155             


Lys Gln  Thr Ile Pro Ser Val  Glu Val Glu Lys Ile  Ala Trp Ala 
    1160                 1165                 1170             


Ser Trp  Thr Ser Val Leu Gly  Leu Cys Cys Glu Gly  Ile Trp Pro 
    1175                 1180                 1185             


Val Ile  Gly Glu Val Thr Asp  Val Thr Ala Ser Cys  Leu Thr Ser 
    1190                 1195                 1200             


Asp Lys  Met Val Leu Ala Thr  Gly Asp Asp Leu Gly  Phe Val Lys 
    1205                 1210                 1215             


Leu Phe  Arg Tyr Pro Thr Lys  Gly Lys Phe Gly Lys  Phe Lys Arg 
    1220                 1225                 1230             


Tyr Val  Ala His Ser Thr His  Val Thr Asn Val Arg  Trp Thr Tyr 
    1235                 1240                 1245             


Asp Asp  Ser Met Leu Val Thr  Leu Gly Gly Thr Asp  Met Ser Leu 
    1250                 1255                 1260             


Met Val  Trp Thr Asn Glu Met  Glu Gly Tyr Arg Glu  Lys Arg Pro 
    1265                 1270                 1275             


Cys Asp  Ser Glu Glu Ser Asp  Ile Asp Ser Glu Glu  Asp Gly Gly 
    1280                 1285                 1290             


Tyr Asp  Ser Asp Val Thr Arg  Glu Asn Glu Ile Ser  Tyr Thr Ile 
    1295                 1300                 1305             


Arg Ala  Leu Ser Thr Asn Ile  Arg Pro Met Leu Gly  Ile Lys Pro 
    1310                 1315                 1320             


His Leu  Gln Gln Lys Glu Pro  Ser Ile Asp Glu Arg  Gln Gly Val 
    1325                 1330                 1335             


Val Arg  Gly Ser Arg Pro Pro  Val Ser Arg Ala Pro  Pro Gln Pro 
    1340                 1345                 1350             


Glu Lys  Leu Gln Thr Asn Asn  Val Gly Lys Lys Lys  Arg Pro Ile 
    1355                 1360                 1365             


Glu Asp  Leu Val Leu Glu Leu  Ile Phe Gly Tyr Arg  Gly Arg Asp 
    1370                 1375                 1380             


Cys Arg  Asn Asn Val His Tyr  Leu Asn Asp Gly Asp  Asp Ile Ile 
    1385                 1390                 1395             


Tyr His  Thr Ala Ser Val Gly  Ile Leu His Asn Val  Ala Thr Gly 
    1400                 1405                 1410             


Ser Gln  Ser Phe Tyr Gln Glu  His Asn Asp Asp Ile  Leu Cys Leu 
    1415                 1420                 1425             


Thr Val  Asn Gln His Pro Lys  Phe Ile Asn Ile Val  Ala Thr Gly 
    1430                 1435                 1440             


Gln Val  Gly Asp Ser Ala Asp  Met Ser Ala Thr Ala  Pro Ser Ile 
    1445                 1450                 1455             


His Ile  Trp Asp Ala Met Asn  Lys Gln Thr Leu Ser  Ile Leu Arg 
    1460                 1465                 1470             


Cys Tyr  His Ser Lys Gly Val  Cys Ser Val Ser Phe  Ser Ala Thr 
    1475                 1480                 1485             


Gly Lys  Leu Leu Leu Ser Val  Gly Leu Asp Pro Glu  His Thr Ile 
    1490                 1495                 1500             


Thr Ile  Trp Arg Trp Gln Glu  Gly Ala Lys Ile Ala  Ser Arg Ala 
    1505                 1510                 1515             


Gly His  Asn Gln Arg Ile Phe  Val Ala Glu Phe Arg  Pro Asp Ser 
    1520                 1525                 1530             


Asp Thr  Gln Phe Val Ser Val  Gly Val Lys His Val  Lys Phe Trp 
    1535                 1540                 1545             


Thr Leu  Ala Gly Arg Ala Leu  Leu Ser Lys Lys Gly  Leu Leu Ser 
    1550                 1555                 1560             


Thr Leu  Glu Asp Ala Arg Met  Gln Thr Met Leu Ala  Ile Ala Phe 
    1565                 1570                 1575             


Gly Ala  Asn Asn Leu Thr Phe  Thr Gly Thr Ile Ser  Gly Asp Val 
    1580                 1585                 1590             


Cys Val  Trp Lys Asp His Ile  Leu Cys Arg Ile Val  Ala Arg Ala 
    1595                 1600                 1605             


His Asn  Gly Pro Val Phe Ala  Met Tyr Thr Thr Leu  Arg Asp Gly 
    1610                 1615                 1620             


Leu Ile  Val Thr Gly Gly Lys  Glu Arg Pro Ser Lys  Glu Gly Gly 
    1625                 1630                 1635             


Ala Val  Lys Leu Trp Asp Gln  Glu Leu Arg Arg Cys  Arg Ala Phe 
    1640                 1645                 1650             


Arg Leu  Glu Thr Gly Gln Ala  Thr Asp Cys Val Arg  Ser Val Cys 
    1655                 1660                 1665             


Arg Gly  Lys Gly Lys Ile Leu  Val Gly Thr Arg Asn  Ala Glu Ile 
    1670                 1675                 1680             


Ile Glu  Val Gly Glu Lys Asn  Ala Ala Cys Asn Ile  Leu Val Asn 
    1685                 1690                 1695             


Gly His  Val Asp Gly Pro Ile  Trp Gly Leu Ala Thr  His Pro Ser 
    1700                 1705                 1710             


Arg Asp  Phe Phe Leu Ser Ala  Ala Glu Asp Gly Thr  Val Arg Leu 
    1715                 1720                 1725             


Trp Asp  Ile Ala Asp Lys Lys  Met Leu Asn Lys Val  Asn Leu Gly 
    1730                 1735                 1740             


His Ala  Ala Arg Thr Val Cys  Tyr Ser Pro Glu Gly  Asp Met Val 
    1745                 1750                 1755             


Ala Ile  Gly Met Lys Asn Gly  Glu Phe Ile Ile Leu  Leu Val Ser 
    1760                 1765                 1770             


Ser Leu  Lys Ile Trp Gly Lys  Lys Arg Asp Arg Arg  Cys Ala Ile 
    1775                 1780                 1785             


His Asp  Ile Arg Phe Ser Pro  Asp Ser Arg Tyr Leu  Ala Val Gly 
    1790                 1795                 1800             


Ser Ser  Glu Asn Ser Val Asp  Phe Tyr Asp Leu Thr  Leu Gly Pro 
    1805                 1810                 1815             


Thr Leu  Asn Arg Ile Ser Tyr  Cys Lys Asp Ile Pro  Ser Phe Val 
    1820                 1825                 1830             


Ile Gln  Met Asp Phe Ser Ala  Asp Ser Ser Tyr Leu  Gln Val Ser 
    1835                 1840                 1845             


Ser Gly  Cys Tyr Lys Arg His  Val Tyr Glu Val Pro  Ser Gly Lys 
    1850                 1855                 1860             


His Leu  Met Asp His Ala Ala  Ile Asp Arg Ile Thr  Trp Ala Thr 
    1865                 1870                 1875             


Trp Thr  Ser Ile Leu Gly Asp  Glu Val Leu Gly Ile  Trp Ser Arg 
    1880                 1885                 1890             


His Ala  Glu Lys Ala Asp Val  Asn Cys Ala Cys Val  Ser His Ser 
    1895                 1900                 1905             


Gly Ile  Ser Leu Val Thr Gly  Asp Asp Phe Gly Met  Val Lys Leu 
    1910                 1915                 1920             


Phe Asp  Phe Pro Cys Pro Glu  Lys Phe Ala Lys His  Lys Arg Phe 
    1925                 1930                 1935             


Leu Gly  His Ser Pro His Val  Thr Asn Ile Arg Phe  Thr Ser Gly 
    1940                 1945                 1950             


Asp Arg  His Val Val Ser Ala  Gly Gly Asp Asp Cys  Ser Leu Phe 
    1955                 1960                 1965             


Val Trp  Lys Cys Val His Thr  Pro His 
    1970                 1975         


<210>  3542
<211>  1958
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EML6__Homo_sapiens__NP_001034842

<400>  3542

Met Ala Asp Arg Thr Ala Pro Arg Cys Gln Leu Arg Leu Glu Trp Val 
1               5                   10                  15      


Tyr Gly Tyr Arg Gly His Gln Cys Arg Asn Asn Leu Tyr Tyr Thr Ala 
            20                  25                  30          


Gly Lys Glu Val Val Tyr Phe Val Ala Gly Val Gly Val Val Tyr Asn 
        35                  40                  45              


Thr Arg Glu His Ser Gln Lys Phe Phe Leu Gly His Asn Asp Asp Ile 
    50                  55                  60                  


Ile Ser Leu Ala Leu His Pro Asp Lys Thr Leu Val Ala Thr Gly Gln 
65                  70                  75                  80  


Val Gly Lys Glu Pro Tyr Ile Cys Ile Trp Asp Ser Tyr Asn Val Gln 
                85                  90                  95      


Thr Val Ser Leu Leu Lys Asp Val His Thr His Gly Val Ala Cys Leu 
            100                 105                 110         


Ala Phe Asp Ser Asp Gly Gln Arg Leu Ala Ser Val Gly Leu Asp Ala 
        115                 120                 125             


Lys Asn Thr Val Cys Ile Trp Asp Trp Arg Lys Gly Lys Leu Leu Ala 
    130                 135                 140                 


Ser Ala Thr Gly His Ser Asp Arg Ile Phe Asp Ile Ser Trp Asp Pro 
145                 150                 155                 160 


Tyr Gln Pro Asn Arg Val Val Ser Cys Gly Val Lys His Ile Lys Phe 
                165                 170                 175     


Trp Thr Leu Cys Gly Asn Ala Leu Thr Ala Lys Arg Gly Ile Phe Gly 
            180                 185                 190         


Lys Thr Gly Asp Leu Gln Thr Ile Leu Cys Leu Ala Cys Ala Lys Glu 
        195                 200                 205             


Asp Ile Thr Tyr Ser Gly Ala Leu Asn Gly Asp Ile Tyr Val Trp Lys 
    210                 215                 220                 


Gly Leu Asn Leu Val Arg Thr Ile Gln Gly Ala His Ser Ala Gly Ile 
225                 230                 235                 240 


Phe Ser Met Tyr Ala Cys Glu Glu Gly Phe Ala Thr Gly Gly Arg Asp 
                245                 250                 255     


Gly Cys Ile Arg Leu Trp Asp Thr Asp Phe Lys Pro Ile Thr Lys Ile 
            260                 265                 270         


Asp Leu Arg Glu Thr Glu Gln Gly Tyr Lys Gly Leu Ser Ile Arg Ser 
        275                 280                 285             


Val Cys Trp Lys Ala Asp Arg Leu Leu Ala Gly Thr Gln Asp Ser Glu 
    290                 295                 300                 


Ile Phe Glu Val Ile Val Arg Glu Arg Asp Lys Pro Met Leu Ile Leu 
305                 310                 315                 320 


Gln Gly His Cys Glu Gly Glu Leu Trp Ala Leu Ala Leu His Pro Lys 
                325                 330                 335     


Lys Pro Leu Ala Val Thr Gly Ser Asp Asp Arg Ser Val Arg Leu Trp 
            340                 345                 350         


Ser Leu Ala Asp His Ala Leu Ile Ala Arg Cys Asn Met Glu Glu Ala 
        355                 360                 365             


Val Arg Ser Val Ala Phe Ser Pro Asp Gly Ser Gln Leu Ala Leu Gly 
    370                 375                 380                 


Met Lys Asp Gly Ser Phe Ile Val Leu Arg Val Arg Asp Met Thr Glu 
385                 390                 395                 400 


Val Val His Ile Lys Asp Arg Lys Glu Val Ile His Glu Met Lys Phe 
                405                 410                 415     


Ser Pro Asp Gly Ser Tyr Leu Ala Val Gly Ser Asn Asp Gly Pro Val 
            420                 425                 430         


Asp Val Tyr Ala Val Ala Gln Arg Tyr Lys Lys Ile Gly Glu Cys Ser 
        435                 440                 445             


Lys Ser Leu Ser Phe Ile Thr His Ile Asp Trp Ser Leu Asp Ser Lys 
    450                 455                 460                 


Tyr Leu Gln Thr Asn Asp Gly Ala Gly Glu Arg Leu Phe Tyr Arg Met 
465                 470                 475                 480 


Pro Ser Gly Lys Pro Leu Thr Ser Lys Glu Glu Ile Lys Gly Ile Pro 
                485                 490                 495     


Trp Ala Ser Trp Thr Cys Val Lys Gly Pro Glu Val Ser Gly Ile Trp 
            500                 505                 510         


Pro Lys Tyr Thr Glu Val Thr Asp Ile Asn Ser Val Asp Ala Asn Tyr 
        515                 520                 525             


Asn Ser Ser Val Leu Val Ser Gly Asp Asp Phe Gly Leu Val Lys Leu 
    530                 535                 540                 


Phe Lys Phe Pro Cys Leu Lys Arg Gly Ala Lys Phe Arg Lys Tyr Val 
545                 550                 555                 560 


Gly His Ser Ala His Val Thr Asn Val Arg Trp Ser His Asp Phe Gln 
                565                 570                 575     


Trp Val Leu Ser Thr Gly Gly Ala Asp His Ser Val Phe Gln Trp Arg 
            580                 585                 590         


Phe Ile Pro Glu Gly Val Ser Asn Gly Met Leu Glu Thr Ala Pro Gln 
        595                 600                 605             


Glu Gly Gly Ala Asp Ser Tyr Ser Glu Glu Ser Asp Ser Asp Leu Ser 
    610                 615                 620                 


Asp Val Pro Glu Leu Asp Ser Asp Ile Glu Gln Glu Ala Gln Ile Asn 
625                 630                 635                 640 


Tyr Asp Arg Gln Val Tyr Lys Glu Asp Leu Pro Gln Leu Lys Gln Gln 
                645                 650                 655     


Ser Lys Glu Lys Asn His Ala Val Pro Phe Leu Lys Arg Glu Lys Ala 
            660                 665                 670         


Pro Glu Asp Ser Leu Lys Leu Gln Phe Ile His Gly Tyr Arg Gly Tyr 
        675                 680                 685             


Asp Cys Arg Asn Asn Leu Phe Tyr Thr Gln Ala Gly Glu Val Val Tyr 
    690                 695                 700                 


His Ile Ala Ala Val Ala Val Val Tyr Asn Arg Gln Gln His Ser Gln 
705                 710                 715                 720 


Arg Leu Tyr Leu Gly His Asp Asp Asp Ile Leu Ser Leu Thr Ile His 
                725                 730                 735     


Pro Val Lys Asp Tyr Val Ala Thr Gly Gln Val Gly Arg Asp Ala Ala 
            740                 745                 750         


Ile His Val Trp Asp Thr Gln Thr Leu Lys Cys Leu Ser Leu Leu Lys 
        755                 760                 765             


Gly Gln His Gln Arg Gly Val Cys Ala Leu Asp Phe Ser Ala Asp Gly 
    770                 775                 780                 


Lys Cys Leu Val Ser Val Gly Leu Asp Asp Phe His Ser Ile Val Phe 
785                 790                 795                 800 


Trp Asp Trp Lys Lys Gly Glu Lys Ile Ala Thr Thr Arg Gly His Lys 
                805                 810                 815     


Asp Lys Ile Phe Val Val Lys Cys Asn Pro His His Val Asp Lys Leu 
            820                 825                 830         


Val Thr Val Gly Ile Lys His Ile Lys Phe Trp Gln Gln Ala Gly Gly 
        835                 840                 845             


Gly Phe Thr Ser Lys Arg Gly Thr Phe Gly Ser Val Gly Lys Leu Glu 
    850                 855                 860                 


Thr Met Met Cys Val Ser Tyr Gly Arg Met Glu Asp Leu Val Phe Ser 
865                 870                 875                 880 


Gly Ala Ala Thr Gly Asp Ile Phe Ile Trp Lys Asp Ile Leu Leu Leu 
                885                 890                 895     


Lys Thr Val Lys Ala His Asp Gly Pro Val Phe Ala Met Tyr Ala Leu 
            900                 905                 910         


Asp Lys Gly Phe Val Thr Gly Gly Lys Asp Gly Ile Val Glu Leu Trp 
        915                 920                 925             


Asp Asp Met Phe Glu Arg Cys Leu Lys Thr Tyr Ala Ile Lys Arg Ser 
    930                 935                 940                 


Ala Leu Ser Thr Ser Ser Lys Gly Leu Leu Leu Glu Asp Asn Pro Ser 
945                 950                 955                 960 


Ile Arg Ala Ile Thr Leu Gly His Gly His Ile Leu Val Gly Thr Lys 
                965                 970                 975     


Asn Gly Glu Ile Leu Glu Ile Asp Lys Ser Gly Pro Met Thr Leu Leu 
            980                 985                 990         


Val Gln Gly His Met Glu Gly Glu  Val Trp Gly Leu Ala  Ala His Pro 
        995                 1000                 1005             


Leu Leu  Pro Ile Cys Ala Thr  Val Ser Asp Asp Lys  Thr Leu Arg 
    1010                 1015                 1020             


Ile Trp  Glu Leu Ser Ala Gln  His Arg Met Leu Ala  Val Arg Lys 
    1025                 1030                 1035             


Leu Lys  Lys Gly Gly Arg Cys  Cys Ala Phe Ser Pro  Asp Gly Lys 
    1040                 1045                 1050             


Ala Leu  Ala Val Gly Leu Asn  Asp Gly Ser Phe Leu  Val Val Asn 
    1055                 1060                 1065             


Ala Asp  Thr Val Glu Asp Met  Val Ser Phe His His  Arg Lys Glu 
    1070                 1075                 1080             


Met Ile  Ser Asp Ile Lys Phe  Ser Lys Asp Thr Gly  Lys Tyr Leu 
    1085                 1090                 1095             


Ala Val  Ala Ser His Asp Asn  Phe Val Asp Ile Tyr  Asn Val Leu 
    1100                 1105                 1110             


Thr Ser  Lys Arg Val Gly Ile  Cys Lys Gly Ala Ser  Ser Tyr Ile 
    1115                 1120                 1125             


Thr His  Ile Asp Trp Asp Ser  Arg Gly Lys Leu Leu  Gln Val Asn 
    1130                 1135                 1140             


Ser Gly  Ala Arg Glu Gln Leu  Phe Phe Glu Ala Pro  Arg Gly Lys 
    1145                 1150                 1155             


Arg His  Ile Ile Arg Pro Ser  Glu Ile Glu Lys Ile  Glu Trp Asp 
    1160                 1165                 1170             


Thr Trp  Thr Cys Val Leu Gly  Pro Thr Cys Glu Gly  Ile Trp Pro 
    1175                 1180                 1185             


Ala His  Ser Asp Ile Thr Asp  Val Asn Ala Ala Ser  Leu Thr Lys 
    1190                 1195                 1200             


Asp Cys  Ser Leu Leu Ala Thr  Gly Asp Asp Phe Gly  Phe Val Lys 
    1205                 1210                 1215             


Leu Phe  Ser Tyr Pro Val Lys  Gly Gln His Ala Arg  Phe Lys Lys 
    1220                 1225                 1230             


Tyr Val  Gly His Ser Ala His  Val Thr Asn Val Arg  Trp Leu His 
    1235                 1240                 1245             


Asn Asp  Ser Val Leu Leu Thr  Val Gly Gly Ala Asp  Thr Ala Leu 
    1250                 1255                 1260             


Met Ile  Trp Thr Arg Glu Phe  Val Gly Thr Gln Glu  Ser Lys Leu 
    1265                 1270                 1275             


Val Asp  Ser Glu Glu Ser Asp  Thr Asp Val Glu Glu  Asp Gly Gly 
    1280                 1285                 1290             


Tyr Asp  Ser Asp Val Ala Arg  Glu Lys Ala Ile Asp  Tyr Thr Thr 
    1295                 1300                 1305             


Lys Ile  Tyr Ala Val Ser Ile  Arg Glu Met Glu Gly  Thr Lys Pro 
    1310                 1315                 1320             


His Gln  Gln Leu Lys Glu Val  Ser Val Glu Glu Arg  Pro Pro Val 
    1325                 1330                 1335             


Ser Arg  Ala Ala Pro Gln Pro  Glu Lys Leu Gln Lys  Asn Asn Ile 
    1340                 1345                 1350             


Thr Lys  Lys Lys Lys Leu Val  Glu Glu Leu Ala Leu  Asp His Val 
    1355                 1360                 1365             


Phe Gly  Tyr Arg Gly Phe Asp  Cys Arg Asn Asn Leu  His Tyr Leu 
    1370                 1375                 1380             


Asn Asp  Gly Ala Asp Ile Ile  Phe His Thr Ala Ala  Ala Gly Ile 
    1385                 1390                 1395             


Val Gln  Asn Leu Ser Thr Gly  Ser Gln Ser Phe Tyr  Leu Glu His 
    1400                 1405                 1410             


Thr Asp  Asp Ile Leu Cys Leu  Thr Val Asn Gln His  Pro Lys Tyr 
    1415                 1420                 1425             


Arg Asn  Val Val Ala Thr Ser  Gln Ile Gly Thr Thr  Pro Ser Ile 
    1430                 1435                 1440             


His Ile  Trp Asp Ala Met Thr  Lys His Thr Leu Ser  Met Leu Arg 
    1445                 1450                 1455             


Cys Phe  His Ser Lys Gly Val  Asn Tyr Ile Asn Phe  Ser Ala Thr 
    1460                 1465                 1470             


Gly Lys  Leu Leu Val Ser Val  Gly Val Asp Pro Glu  His Thr Ile 
    1475                 1480                 1485             


Thr Val  Trp Arg Trp Gln Glu  Gly Ala Lys Val Ala  Ser Arg Gly 
    1490                 1495                 1500             


Gly His  Leu Glu Arg Ile Phe  Val Val Glu Phe Arg  Pro Asp Ser 
    1505                 1510                 1515             


Asp Thr  Gln Phe Val Ser Val  Gly Val Lys His Met  Lys Phe Trp 
    1520                 1525                 1530             


Thr Leu  Ala Gly Ser Ala Leu  Leu Tyr Lys Lys Gly  Val Ile Gly 
    1535                 1540                 1545             


Ser Leu  Gly Ala Ala Lys Met  Gln Thr Met Leu Ser  Val Ala Phe 
    1550                 1555                 1560             


Gly Ala  Asn Asn Leu Thr Phe  Thr Gly Ala Ile Asn  Gly Asp Val 
    1565                 1570                 1575             


Tyr Val  Trp Lys Asp His Phe  Leu Ile Arg Leu Val  Ala Lys Ala 
    1580                 1585                 1590             


His Thr  Gly Pro Val Phe Thr  Met Tyr Thr Thr Leu  Arg Asp Gly 
    1595                 1600                 1605             


Leu Ile  Val Thr Gly Gly Lys  Glu Arg Pro Thr Lys  Glu Gly Gly 
    1610                 1615                 1620             


Ala Val  Lys Leu Trp Asp Gln  Glu Met Lys Arg Cys  Arg Ala Phe 
    1625                 1630                 1635             


Gln Leu  Glu Thr Gly Gln Leu  Val Glu Cys Val Arg  Ser Val Cys 
    1640                 1645                 1650             


Arg Gly  Lys Gly Lys Ile Leu  Val Gly Thr Lys Asp  Gly Glu Ile 
    1655                 1660                 1665             


Ile Glu  Val Gly Glu Lys Asn  Ala Ala Ser Asn Ile  Leu Ile Asp 
    1670                 1675                 1680             


Gly His  Met Glu Gly Glu Ile  Trp Gly Leu Ala Thr  His Pro Ser 
    1685                 1690                 1695             


Lys Asp  Leu Phe Ile Ser Ala  Ser Asn Asp Gly Thr  Ala Arg Ile 
    1700                 1705                 1710             


Trp Asp  Leu Ala Asp Lys Lys  Leu Leu Asn Lys Val  Ser Leu Gly 
    1715                 1720                 1725             


His Ala  Ala Arg Cys Ala Ala  Tyr Ser Pro Asp Gly  Glu Met Val 
    1730                 1735                 1740             


Ala Ile  Gly Met Lys Asn Gly  Glu Phe Val Ile Leu  Leu Val Asn 
    1745                 1750                 1755             


Ser Leu  Lys Val Trp Gly Lys  Lys Arg Asp Arg Lys  Ser Ala Ile 
    1760                 1765                 1770             


Gln Asp  Ile Arg Ile Ser Pro  Asp Asn Arg Phe Leu  Ala Val Gly 
    1775                 1780                 1785             


Ser Ser  Glu His Thr Val Asp  Phe Tyr Asp Leu Thr  Gln Gly Thr 
    1790                 1795                 1800             


Asn Leu  Asn Arg Ile Gly Tyr  Cys Lys Asp Ile Pro  Ser Phe Val 
    1805                 1810                 1815             


Ile Gln  Met Asp Phe Ser Ala  Asp Gly Lys Tyr Ile  Gln Val Ser 
    1820                 1825                 1830             


Thr Gly  Ala Tyr Lys Arg Gln  Val His Glu Val Pro  Leu Gly Lys 
    1835                 1840                 1845             


Gln Val  Thr Glu Ala Val Val  Ile Glu Lys Ile Thr  Trp Ala Ser 
    1850                 1855                 1860             


Trp Thr  Ser Val Leu Gly Asp  Glu Val Ile Gly Ile  Trp Pro Arg 
    1865                 1870                 1875             


Asn Ala  Asp Lys Ala Asp Val  Asn Cys Ala Cys Val  Thr His Ala 
    1880                 1885                 1890             


Gly Leu  Asn Ile Val Thr Gly  Asp Asp Phe Gly Leu  Val Lys Leu 
    1895                 1900                 1905             


Phe Asp  Phe Pro Cys Thr Glu  Lys Phe Ala Lys His  Lys Arg Tyr 
    1910                 1915                 1920             


Phe Gly  His Ser Ala His Val  Thr Asn Ile Arg Phe  Ser Tyr Asp 
    1925                 1930                 1935             


Asp Lys  Tyr Val Val Ser Thr  Gly Gly Asp Asp Cys  Ser Val Phe 
    1940                 1945                 1950             


Val Trp  Arg Cys Leu 
    1955             


<210>  3543
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMP1__Homo_sapiens__NP_001414

<400>  3543

Met Leu Val Leu Leu Ala Gly Ile Phe Val Val His Ile Ala Thr Val 
1               5                   10                  15      


Ile Met Leu Phe Val Ser Thr Ile Ala Asn Val Trp Leu Val Ser Asn 
            20                  25                  30          


Thr Val Asp Ala Ser Val Gly Leu Trp Lys Asn Cys Thr Asn Ile Ser 
        35                  40                  45              


Cys Ser Asp Ser Leu Ser Tyr Ala Ser Glu Asp Ala Leu Lys Thr Val 
    50                  55                  60                  


Gln Ala Phe Met Ile Leu Ser Ile Ile Phe Cys Val Ile Ala Leu Leu 
65                  70                  75                  80  


Val Phe Val Phe Gln Leu Phe Thr Met Glu Lys Gly Asn Arg Phe Phe 
                85                  90                  95      


Leu Ser Gly Ala Thr Thr Leu Val Cys Trp Leu Cys Ile Leu Val Gly 
            100                 105                 110         


Val Ser Ile Tyr Thr Ser His Tyr Ala Asn Arg Asp Gly Thr Gln Tyr 
        115                 120                 125             


His His Gly Tyr Ser Tyr Ile Leu Gly Trp Ile Cys Phe Cys Phe Ser 
    130                 135                 140                 


Phe Ile Ile Gly Val Leu Tyr Leu Val Leu Arg Lys Lys 
145                 150                 155         


<210>  3544
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMP2__Homo_sapiens__XP_006720927

<400>  3544

Met Leu Val Leu Leu Ala Phe Ile Ile Ala Phe His Ile Thr Ser Ala 
1               5                   10                  15      


Ala Leu Leu Phe Ile Ala Thr Val Asp Asn Ala Trp Trp Val Gly Asp 
            20                  25                  30          


Glu Phe Phe Ala Asp Val Trp Arg Ile Cys Thr Asn Asn Thr Asn Cys 
        35                  40                  45              


Thr Val Ile Asn Asp Ser Phe Gln Glu Tyr Ser Thr Leu Gln Ala Val 
    50                  55                  60                  


Gln Ala Thr Met Ile Leu Ser Thr Ile Leu Cys Cys Ile Ala Phe Phe 
65                  70                  75                  80  


Ile Phe Val Leu Gln Leu Phe Arg Leu Lys Gln Gly Glu Arg Phe Val 
                85                  90                  95      


Leu Thr Ser Ile Ile Gln Leu Met Ser Cys Leu Cys Val Met Ile Ala 
            100                 105                 110         


Ala Ser Ile Tyr Thr Asp Arg Arg Glu Asp Ile His Asp Lys Asn Ala 
        115                 120                 125             


Lys Phe Tyr Pro Val Thr Arg Glu Gly Ser Tyr Gly Tyr Ser Tyr Ile 
    130                 135                 140                 


Leu Ala Trp Val Ala Phe Ala Cys Thr Phe Ile Ser Gly Met Met Tyr 
145                 150                 155                 160 


Leu Ile Leu Arg Lys Arg Lys 
                165         


<210>  3545
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMX1__Homo_sapiens__NP_004088

<400>  3545

Met Cys Leu Ala Gly Cys Thr Pro Arg Lys Ala Ala Ala Pro Gly Arg 
1               5                   10                  15      


Gly Ala Leu Pro Arg Ala Arg Leu Pro Arg Thr Ala Pro Ala Ala Ala 
            20                  25                  30          


Thr Met Phe Gln Pro Ala Ala Lys Arg Gly Phe Thr Ile Glu Ser Leu 
        35                  40                  45              


Val Ala Lys Asp Gly Gly Thr Gly Gly Gly Thr Gly Gly Gly Gly Ala 
    50                  55                  60                  


Gly Ser His Leu Leu Ala Ala Ala Ala Ser Glu Glu Pro Leu Arg Pro 
65                  70                  75                  80  


Thr Ala Leu Asn Tyr Pro His Pro Ser Ala Ala Glu Ala Ala Phe Val 
                85                  90                  95      


Ser Gly Phe Pro Ala Ala Ala Ala Ala Gly Ala Gly Arg Ser Leu Tyr 
            100                 105                 110         


Gly Gly Pro Glu Leu Val Phe Pro Glu Ala Met Asn His Pro Ala Leu 
        115                 120                 125             


Thr Val His Pro Ala His Gln Leu Gly Ala Ser Pro Leu Gln Pro Pro 
    130                 135                 140                 


His Ser Phe Phe Gly Ala Gln His Arg Asp Pro Leu His Phe Tyr Pro 
145                 150                 155                 160 


Trp Val Leu Arg Asn Arg Phe Phe Gly His Arg Phe Gln Ala Ser Asp 
                165                 170                 175     


Val Pro Gln Asp Gly Leu Leu Leu His Gly Pro Phe Ala Arg Lys Pro 
            180                 185                 190         


Lys Arg Ile Arg Thr Ala Phe Ser Pro Ser Gln Leu Leu Arg Leu Glu 
        195                 200                 205             


Arg Ala Phe Glu Lys Asn His Tyr Val Val Gly Ala Glu Arg Lys Gln 
    210                 215                 220                 


Leu Ala Gly Ser Leu Ser Leu Ser Glu Thr Gln Val Lys Val Trp Phe 
225                 230                 235                 240 


Gln Asn Arg Arg Thr Lys Tyr Lys Arg Gln Lys Leu Glu Glu Glu Gly 
                245                 250                 255     


Pro Glu Ser Glu Gln Lys Lys Lys Gly Ser His His Ile Asn Arg Trp 
            260                 265                 270         


Arg Ile Ala Thr Lys Gln Ala Asn Gly Glu Asp Ile Asp Val Thr Ser 
        275                 280                 285             


Asn Asp 
    290 


<210>  3546
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMX2__Homo_sapiens__NP_001159396

<400>  3546

Met Phe Gln Pro Ala Pro Lys Arg Cys Phe Thr Ile Glu Ser Leu Val 
1               5                   10                  15      


Ala Lys Asp Ser Pro Leu Pro Ala Ser Arg Ser Glu Asp Pro Ile Arg 
            20                  25                  30          


Pro Ala Ala Leu Ser Tyr Ala Asn Ser Ser Pro Ile Asn Pro Phe Leu 
        35                  40                  45              


Asn Gly Phe His Ser Ala Ala Ala Ala Ala Ala Gly Arg Gly Val Tyr 
    50                  55                  60                  


Ser Asn Pro Asp Leu Val Phe Ala Glu Ala Val Ser His Pro Pro Asn 
65                  70                  75                  80  


Pro Ala Val Pro Val His Pro Val Pro Pro Pro His Ala Leu Ala Ala 
                85                  90                  95      


His Pro Leu Pro Ser Ser His Ser Pro His Pro Leu Phe Ala Ser Gln 
            100                 105                 110         


Gln Arg Asp Pro Ser Thr Phe Tyr Pro Trp Leu Ile His Arg Tyr Arg 
        115                 120                 125             


Tyr Leu Gly His Arg Phe Gln Gly Lys Ser Met Val Ser Glu Pro Lys 
    130                 135                 140                 


Asn Lys Val Gln Lys Ala Glu Ala Gly Gly Arg Arg Leu Arg Phe Ala 
145                 150                 155                 160 


Thr Lys Glu Lys Arg Asp Ala Pro Tyr 
                165                 


<210>  3547
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EN1__Homo_sapiens__NP_001417

<400>  3547

Met Glu Glu Gln Gln Pro Glu Pro Lys Ser Gln Arg Asp Ser Ala Leu 
1               5                   10                  15      


Gly Ala Ala Ala Ala Ala Thr Pro Gly Gly Leu Ser Leu Ser Leu Ser 
            20                  25                  30          


Pro Gly Ala Ser Gly Ser Ser Gly Ser Gly Ser Asp Gly Asp Ser Val 
        35                  40                  45              


Pro Val Ser Pro Gln Pro Ala Pro Pro Ser Pro Pro Ala Ala Pro Cys 
    50                  55                  60                  


Leu Pro Pro Leu Ala His His Pro His Leu Pro Pro His Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Gln His Leu Ala Ala Pro Ala His Gln Pro Gln Pro Ala 
                85                  90                  95      


Ala Gln Leu His Arg Thr Thr Asn Phe Phe Ile Asp Asn Ile Leu Arg 
            100                 105                 110         


Pro Asp Phe Gly Cys Lys Lys Glu Gln Pro Pro Pro Gln Leu Leu Val 
        115                 120                 125             


Ala Ala Ala Ala Arg Gly Gly Ala Gly Gly Gly Gly Arg Val Glu Arg 
    130                 135                 140                 


Asp Arg Gly Gln Thr Ala Ala Gly Arg Asp Pro Val His Pro Leu Gly 
145                 150                 155                 160 


Thr Arg Ala Pro Gly Ala Ala Ser Leu Leu Cys Ala Pro Asp Ala Asn 
                165                 170                 175     


Cys Gly Pro Pro Asp Gly Ser Gln Pro Ala Ala Ala Gly Ala Gly Ala 
            180                 185                 190         


Ser Lys Ala Gly Asn Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Pro Ser Asp Thr Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ala Gly Ser Pro Gly Ala Gln Gly Thr 
225                 230                 235                 240 


Lys Tyr Pro Glu His Gly Asn Pro Ala Ile Leu Leu Met Gly Ser Ala 
                245                 250                 255     


Asn Gly Gly Pro Val Val Lys Thr Asp Ser Gln Gln Pro Leu Val Trp 
            260                 265                 270         


Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser Asp Arg Pro Ser Ser Gly 
        275                 280                 285             


Pro Arg Thr Arg Lys Leu Lys Lys Lys Lys Asn Glu Lys Glu Asp Lys 
    290                 295                 300                 


Arg Pro Arg Thr Ala Phe Thr Ala Glu Gln Leu Gln Arg Leu Lys Ala 
305                 310                 315                 320 


Glu Phe Gln Ala Asn Arg Tyr Ile Thr Glu Gln Arg Arg Gln Thr Leu 
                325                 330                 335     


Ala Gln Glu Leu Ser Leu Asn Glu Ser Gln Ile Lys Ile Trp Phe Gln 
            340                 345                 350         


Asn Lys Arg Ala Lys Ile Lys Lys Ala Thr Gly Ile Lys Asn Gly Leu 
        355                 360                 365             


Ala Leu His Leu Met Ala Gln Gly Leu Tyr Asn His Ser Thr Thr Thr 
    370                 375                 380                 


Val Gln Asp Lys Asp Glu Ser Glu 
385                 390         


<210>  3548
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EN2__Homo_sapiens__NP_001418

<400>  3548

Met Glu Glu Asn Asp Pro Lys Pro Gly Glu Ala Ala Ala Ala Val Glu 
1               5                   10                  15      


Gly Gln Arg Gln Pro Glu Ser Ser Pro Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Ser Pro Gly Glu Ala Asp Thr Gly Arg Arg Arg Ala Leu 
        35                  40                  45              


Met Leu Pro Ala Val Leu Gln Ala Pro Gly Asn His Gln His Pro His 
    50                  55                  60                  


Arg Ile Thr Asn Phe Phe Ile Asp Asn Ile Leu Arg Pro Glu Phe Gly 
65                  70                  75                  80  


Arg Arg Lys Asp Ala Gly Thr Cys Cys Ala Gly Ala Gly Gly Gly Arg 
                85                  90                  95      


Gly Gly Gly Ala Gly Gly Glu Gly Gly Ala Ser Gly Ala Glu Gly Gly 
            100                 105                 110         


Gly Gly Ala Gly Gly Ser Glu Gln Leu Leu Gly Ser Gly Ser Arg Glu 
        115                 120                 125             


Pro Arg Gln Asn Pro Pro Cys Ala Pro Gly Ala Gly Gly Pro Leu Pro 
    130                 135                 140                 


Ala Ala Gly Ser Asp Ser Pro Gly Asp Gly Glu Gly Gly Ser Lys Thr 
145                 150                 155                 160 


Leu Ser Leu His Gly Gly Ala Lys Lys Gly Gly Asp Pro Gly Gly Pro 
                165                 170                 175     


Leu Asp Gly Ser Leu Lys Ala Arg Gly Leu Gly Gly Gly Asp Leu Ser 
            180                 185                 190         


Val Ser Ser Asp Ser Asp Ser Ser Gln Ala Gly Ala Asn Leu Gly Ala 
        195                 200                 205             


Gln Pro Met Leu Trp Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser Asp 
    210                 215                 220                 


Arg Pro Ser Ser Gly Pro Arg Ser Arg Lys Pro Lys Lys Lys Asn Pro 
225                 230                 235                 240 


Asn Lys Glu Asp Lys Arg Pro Arg Thr Ala Phe Thr Ala Glu Gln Leu 
                245                 250                 255     


Gln Arg Leu Lys Ala Glu Phe Gln Thr Asn Arg Tyr Leu Thr Glu Gln 
            260                 265                 270         


Arg Arg Gln Ser Leu Ala Gln Glu Leu Ser Leu Asn Glu Ser Gln Ile 
        275                 280                 285             


Lys Ile Trp Phe Gln Asn Lys Arg Ala Lys Ile Lys Lys Ala Thr Gly 
    290                 295                 300                 


Asn Lys Asn Thr Leu Ala Val His Leu Met Ala Gln Gly Leu Tyr Asn 
305                 310                 315                 320 


His Ser Thr Thr Ala Lys Glu Gly Lys Ser Asp Ser Glu 
                325                 330             


<210>  3549
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENAH__Homo_sapiens__NP_001008493

<400>  3549

Met Ser Glu Gln Ser Ile Cys Gln Ala Arg Ala Ala Val Met Val Tyr 
1               5                   10                  15      


Asp Asp Ala Asn Lys Lys Trp Val Pro Ala Gly Gly Ser Thr Gly Phe 
            20                  25                  30          


Ser Arg Val His Ile Tyr His His Thr Gly Asn Asn Thr Phe Arg Val 
        35                  40                  45              


Val Gly Arg Lys Ile Gln Asp His Gln Val Val Ile Asn Cys Ala Ile 
    50                  55                  60                  


Pro Lys Gly Leu Lys Tyr Asn Gln Ala Thr Gln Thr Phe His Gln Trp 
65                  70                  75                  80  


Arg Asp Ala Arg Gln Val Tyr Gly Leu Asn Phe Gly Ser Lys Glu Asp 
                85                  90                  95      


Ala Asn Val Phe Ala Ser Ala Met Met His Ala Leu Glu Val Leu Asn 
            100                 105                 110         


Ser Gln Glu Thr Gly Pro Thr Leu Pro Arg Gln Asn Ser Gln Leu Pro 
        115                 120                 125             


Ala Gln Val Gln Asn Gly Pro Ser Gln Glu Glu Leu Glu Ile Gln Arg 
    130                 135                 140                 


Arg Gln Leu Gln Glu Gln Gln Arg Gln Lys Glu Leu Glu Arg Glu Arg 
145                 150                 155                 160 


Leu Glu Arg Glu Arg Met Glu Arg Glu Arg Leu Glu Arg Glu Arg Leu 
                165                 170                 175     


Glu Arg Glu Arg Leu Glu Arg Glu Arg Leu Glu Gln Glu Gln Leu Glu 
            180                 185                 190         


Arg Glu Arg Gln Glu Arg Glu Arg Gln Glu Arg Leu Glu Arg Gln Glu 
        195                 200                 205             


Arg Leu Glu Arg Gln Glu Arg Leu Glu Arg Gln Glu Arg Leu Asp Arg 
    210                 215                 220                 


Glu Arg Gln Glu Arg Gln Glu Arg Glu Arg Leu Glu Arg Leu Glu Arg 
225                 230                 235                 240 


Glu Arg Gln Glu Arg Glu Arg Gln Glu Gln Leu Glu Arg Glu Gln Leu 
                245                 250                 255     


Glu Trp Glu Arg Glu Arg Arg Ile Ser Ser Ala Ala Ala Pro Ala Ser 
            260                 265                 270         


Val Glu Thr Pro Leu Asn Ser Val Leu Gly Asp Ser Ser Ala Ser Glu 
        275                 280                 285             


Pro Gly Leu Gln Ala Ala Ser Gln Pro Ala Glu Thr Pro Ser Gln Gln 
    290                 295                 300                 


Gly Ile Val Leu Gly Pro Leu Ala Pro Pro Pro Pro Pro Pro Leu Pro 
305                 310                 315                 320 


Pro Gly Pro Ala Gln Ala Ser Val Ala Leu Pro Pro Pro Pro Gly Pro 
                325                 330                 335     


Pro Pro Pro Pro Pro Leu Pro Ser Thr Gly Pro Pro Pro Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Leu Pro Asn Gln Val Pro Pro Pro Pro Pro Pro Pro Pro 
        355                 360                 365             


Ala Pro Pro Leu Pro Ala Ser Gly Phe Phe Leu Ala Ser Met Ser Glu 
    370                 375                 380                 


Asp Asn Arg Pro Leu Thr Gly Leu Ala Ala Ala Ile Ala Gly Ala Lys 
385                 390                 395                 400 


Leu Arg Lys Val Ser Arg Met Glu Asp Thr Ser Phe Pro Ser Gly Gly 
                405                 410                 415     


Asn Ala Ile Gly Val Asn Ser Ala Ser Ser Lys Thr Asp Thr Gly Arg 
            420                 425                 430         


Gly Asn Gly Pro Leu Pro Leu Gly Gly Ser Gly Leu Met Glu Glu Met 
        435                 440                 445             


Ser Ala Leu Leu Ala Arg Arg Arg Arg Ile Ala Glu Lys Gly Ser Thr 
    450                 455                 460                 


Ile Glu Thr Glu Gln Lys Glu Asp Lys Gly Glu Asp Ser Glu Pro Val 
465                 470                 475                 480 


Thr Ser Lys Ala Ser Ser Thr Ser Thr Pro Glu Pro Thr Arg Lys Pro 
                485                 490                 495     


Trp Glu Arg Thr Asn Thr Met Asn Gly Ser Lys Ser Pro Val Ile Ser 
            500                 505                 510         


Arg Arg Asp Ser Pro Arg Lys Asn Gln Ile Val Phe Asp Asn Arg Ser 
        515                 520                 525             


Tyr Asp Ser Leu His Arg Pro Lys Ser Thr Pro Leu Ser Gln Pro Ser 
    530                 535                 540                 


Ala Asn Gly Val Gln Thr Glu Gly Leu Asp Tyr Asp Arg Leu Lys Gln 
545                 550                 555                 560 


Asp Ile Leu Asp Glu Met Arg Lys Glu Leu Thr Lys Leu Lys Glu Glu 
                565                 570                 575     


Leu Ile Asp Ala Ile Arg Gln Glu Leu Ser Lys Ser Asn Thr Ala 
            580                 585                 590     


<210>  3550
<211>  1142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENAM__Homo_sapiens__NP_114095

<400>  3550

Met Leu Val Leu Arg Cys Arg Leu Gly Thr Ser Phe Pro Lys Leu Asp 
1               5                   10                  15      


Asn Leu Val Pro Lys Gly Lys Met Lys Ile Leu Leu Val Phe Leu Gly 
            20                  25                  30          


Leu Leu Gly Asn Ser Val Ala Met Pro Met His Met Pro Arg Met Pro 
        35                  40                  45              


Gly Phe Ser Ser Lys Ser Glu Glu Met Met Arg Tyr Asn Gln Phe Asn 
    50                  55                  60                  


Phe Met Asn Gly Pro His Met Ala His Leu Gly Pro Phe Phe Gly Asn 
65                  70                  75                  80  


Gly Leu Pro Gln Gln Phe Pro Gln Tyr Gln Met Pro Met Trp Pro Gln 
                85                  90                  95      


Pro Pro Pro Asn Thr Trp His Pro Arg Lys Ser Ser Ala Pro Lys Arg 
            100                 105                 110         


His Asn Lys Thr Asp Gln Thr Gln Glu Thr Gln Lys Pro Asn Gln Thr 
        115                 120                 125             


Gln Ser Lys Lys Pro Pro Gln Lys Arg Pro Leu Lys Gln Pro Ser His 
    130                 135                 140                 


Asn Gln Pro Gln Pro Glu Glu Glu Ala Gln Pro Pro Gln Ala Phe Pro 
145                 150                 155                 160 


Pro Phe Gly Asn Gly Leu Phe Pro Tyr Gln Gln Pro Pro Trp Gln Ile 
                165                 170                 175     


Pro Gln Arg Leu Pro Pro Pro Gly Tyr Gly Arg Pro Pro Ile Ser Asn 
            180                 185                 190         


Glu Glu Gly Gly Asn Pro Tyr Phe Gly Tyr Phe Gly Tyr His Gly Phe 
        195                 200                 205             


Gly Gly Arg Pro Pro Tyr Tyr Ser Glu Glu Met Phe Glu Gln Asp Phe 
    210                 215                 220                 


Glu Lys Pro Lys Glu Glu Asp Pro Pro Lys Ala Glu Ser Pro Gly Thr 
225                 230                 235                 240 


Glu Pro Thr Ala Asn Ser Thr Val Thr Glu Thr Asn Ser Thr Gln Pro 
                245                 250                 255     


Asn Pro Lys Gly Ser Gln Gly Gly Asn Asp Thr Ser Pro Thr Gly Asn 
            260                 265                 270         


Ser Thr Pro Gly Leu Asn Thr Gly Asn Asn Pro Pro Ala Gln Asn Gly 
        275                 280                 285             


Ile Gly Pro Leu Pro Ala Val Asn Ala Ser Gly Gln Gly Gly Pro Gly 
    290                 295                 300                 


Ser Gln Ile Pro Trp Arg Pro Ser Gln Pro Asn Ile Arg Glu Asn His 
305                 310                 315                 320 


Pro Tyr Pro Asn Ile Arg Asn Phe Pro Ser Gly Arg Gln Trp Tyr Phe 
                325                 330                 335     


Thr Gly Thr Val Met Gly His Arg Gln Asn Arg Pro Phe Tyr Arg Asn 
            340                 345                 350         


Gln Gln Val Gln Arg Gly Pro Arg Trp Asn Phe Phe Ala Trp Glu Arg 
        355                 360                 365             


Lys Gln Val Ala Arg Pro Gly Asn Pro Val Tyr His Lys Ala Tyr Pro 
    370                 375                 380                 


Pro Thr Ser Arg Gly Asn Tyr Pro Asn Tyr Ala Gly Asn Pro Ala Asn 
385                 390                 395                 400 


Leu Arg Arg Lys Pro Gln Gly Pro Asn Lys His Pro Val Gly Thr Thr 
                405                 410                 415     


Val Ala Pro Leu Gly Pro Lys Pro Gly Pro Val Val Arg Asn Glu Lys 
            420                 425                 430         


Ile Gln Asn Pro Lys Glu Lys Pro Leu Gly Pro Lys Glu Gln Ile Ile 
        435                 440                 445             


Val Pro Thr Lys Asn Pro Thr Ser Pro Trp Arg Asn Ser Gln Gln Tyr 
    450                 455                 460                 


Glu Val Asn Lys Ser Asn Tyr Lys Leu Pro His Ser Glu Gly Tyr Met 
465                 470                 475                 480 


Pro Val Pro Asn Phe Asn Ser Val Asp Gln His Glu Asn Ser Tyr Tyr 
                485                 490                 495     


Pro Arg Gly Asp Ser Arg Lys Val Pro Asn Ser Asp Gly Gln Thr Gln 
            500                 505                 510         


Ser Gln Asn Leu Pro Lys Gly Ile Val Leu Gly Ser Arg Arg Met Pro 
        515                 520                 525             


Tyr Glu Ser Glu Thr Asn Gln Ser Glu Leu Lys His Ser Ser Tyr Gln 
    530                 535                 540                 


Pro Ala Val Tyr Pro Glu Glu Ile Pro Ser Pro Ala Lys Glu His Phe 
545                 550                 555                 560 


Pro Ala Gly Arg Asn Thr Trp Asp His Gln Glu Ile Ser Pro Pro Phe 
                565                 570                 575     


Lys Glu Asp Pro Gly Arg Gln Glu Glu His Leu Pro His Pro Ser His 
            580                 585                 590         


Gly Ser Arg Gly Ser Val Phe Tyr Pro Glu Tyr Asn Pro Tyr Asp Pro 
        595                 600                 605             


Arg Glu Asn Ser Pro Tyr Leu Arg Gly Asn Thr Trp Asp Glu Arg Asp 
    610                 615                 620                 


Asp Ser Pro Asn Thr Met Gly Gln Lys Glu Ser Pro Leu Tyr Pro Ile 
625                 630                 635                 640 


Asn Thr Pro Asp Gln Lys Glu Ile Val Pro Tyr Asn Glu Glu Asp Pro 
                645                 650                 655     


Val Asp Pro Thr Gly Asp Glu Val Phe Pro Gly Gln Asn Arg Trp Gly 
            660                 665                 670         


Glu Glu Leu Ser Phe Lys Gly Gly Pro Thr Val Arg His Tyr Glu Gly 
        675                 680                 685             


Glu Gln Tyr Thr Ser Asn Gln Pro Lys Glu Tyr Leu Pro Tyr Ser Leu 
    690                 695                 700                 


Asp Asn Pro Ser Lys Pro Arg Glu Asp Phe Tyr Tyr Ser Glu Phe Tyr 
705                 710                 715                 720 


Pro Trp Ser Pro Asp Glu Asn Phe Pro Ser Tyr Asn Thr Ala Ser Thr 
                725                 730                 735     


Met Pro Pro Pro Ile Glu Ser Arg Gly Tyr Tyr Val Asn Asn Ala Ala 
            740                 745                 750         


Gly Pro Glu Glu Ser Thr Leu Phe Pro Ser Arg Asn Ser Trp Asp His 
        755                 760                 765             


Arg Ile Gln Ala Gln Gly Gln Arg Glu Arg Arg Pro Tyr Phe Asn Arg 
    770                 775                 780                 


Asn Ile Trp Asp Gln Ala Thr His Leu Gln Lys Ala Pro Ala Arg Pro 
785                 790                 795                 800 


Pro Asp Gln Lys Gly Asn Gln Pro Tyr Tyr Ser Asn Thr Pro Ala Gly 
                805                 810                 815     


Leu Gln Lys Asn Pro Ile Trp His Glu Gly Glu Asn Leu Asn Tyr Gly 
            820                 825                 830         


Met Gln Ile Thr Arg Met Asn Ser Pro Glu Arg Glu His Ser Ser Phe 
        835                 840                 845             


Pro Asn Phe Ile Pro Pro Ser Tyr Pro Ser Gly Gln Lys Glu Ala His 
    850                 855                 860                 


Leu Phe His Leu Ser Gln Arg Gly Ser Cys Cys Ala Gly Ser Ser Thr 
865                 870                 875                 880 


Gly Pro Lys Asp Asn Pro Leu Ala Leu Gln Asp Tyr Thr Pro Ser Tyr 
                885                 890                 895     


Gly Leu Ala Pro Gly Glu Asn Gln Asp Thr Ser Pro Leu Tyr Thr Asp 
            900                 905                 910         


Gly Ser His Thr Lys Gln Thr Arg Asp Ile Ile Ser Pro Thr Ser Ile 
        915                 920                 925             


Leu Pro Gly Gln Arg Asn Ser Ser Glu Lys Arg Glu Ser Gln Asn Pro 
    930                 935                 940                 


Phe Arg Asp Asp Val Ser Thr Leu Arg Arg Asn Thr Pro Cys Ser Ile 
945                 950                 955                 960 


Lys Asn Gln Leu Gly Gln Lys Glu Ile Met Pro Phe Pro Glu Ala Ser 
                965                 970                 975     


Ser Leu Gln Ser Lys Asn Thr Pro Cys Leu Lys Asn Asp Leu Gly Gly 
            980                 985                 990         


Asp Gly Asn Asn Ile Leu Glu Gln  Val Phe Glu Asp Asn  Gln Leu Asn 
        995                 1000                 1005             


Glu Arg  Thr Val Asp Leu Thr  Pro Glu Gln Leu Val  Ile Gly Thr 
    1010                 1015                 1020             


Pro Asp  Glu Gly Ser Asn Pro  Glu Gly Ile Gln Ser  Gln Val Gln 
    1025                 1030                 1035             


Glu Asn  Glu Ser Glu Arg Gln  Gln Gln Arg Pro Ser  Asn Ile Leu 
    1040                 1045                 1050             


His Leu  Pro Cys Phe Gly Ser  Lys Leu Ala Lys His  His Ser Ser 
    1055                 1060                 1065             


Thr Thr  Gly Thr Pro Ser Ser  Asp Gly Arg Gln Ser  Pro Phe Asp 
    1070                 1075                 1080             


Gly Asp  Ser Ile Thr Pro Thr  Glu Asn Pro Asn Thr  Leu Val Glu 
    1085                 1090                 1095             


Leu Ala  Thr Glu Glu Gln Phe  Lys Ser Ile Asn Val  Asp Pro Leu 
    1100                 1105                 1110             


Asp Ala  Asp Glu His Ser Pro  Phe Glu Phe Leu Gln  Arg Gly Thr 
    1115                 1120                 1125             


Asn Val  Gln Asp Gln Val Gln  Asp Cys Leu Leu Leu  Gln Ala 
    1130                 1135                 1140         


<210>  3551
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENC1__Homo_sapiens__XP_011541999

<400>  3551

Met Ser Val Ser Val His Glu Asn Arg Lys Ser Arg Ala Ser Ser Gly 
1               5                   10                  15      


Ser Ile Asn Ile Tyr Leu Phe His Lys Ser Ser Tyr Ala Asp Ser Val 
            20                  25                  30          


Leu Thr His Leu Asn Leu Leu Arg Gln Gln Arg Leu Phe Thr Asp Val 
        35                  40                  45              


Leu Leu His Ala Gly Asn Arg Thr Phe Pro Cys His Arg Ala Val Leu 
    50                  55                  60                  


Ala Ala Cys Ser Arg Tyr Phe Glu Ala Met Phe Ser Gly Gly Leu Lys 
65                  70                  75                  80  


Glu Ser Gln Asp Ser Glu Val Asn Phe Asp Asn Ser Ile His Pro Glu 
                85                  90                  95      


Val Leu Glu Leu Leu Leu Asp Tyr Ala Tyr Ser Ser Arg Val Ile Ile 
            100                 105                 110         


Asn Glu Glu Asn Ala Glu Ser Leu Leu Glu Ala Gly Asp Met Leu Glu 
        115                 120                 125             


Phe Gln Asp Ile Arg Asp Ala Cys Ala Glu Phe Leu Glu Lys Asn Leu 
    130                 135                 140                 


His Pro Thr Asn Cys Leu Gly Met Leu Leu Leu Ser Asp Ala His Gln 
145                 150                 155                 160 


Cys Thr Lys Leu Tyr Glu Leu Ser Trp Arg Met Cys Leu Ser Asn Phe 
                165                 170                 175     


Gln Thr Ile Arg Lys Asn Glu Asp Phe Leu Gln Leu Pro Gln Asp Met 
            180                 185                 190         


Val Val Gln Leu Leu Ser Ser Glu Glu Leu Glu Thr Glu Asp Glu Arg 
        195                 200                 205             


Leu Val Tyr Glu Ser Ala Ile Asn Trp Ile Ser Tyr Asp Leu Lys Lys 
    210                 215                 220                 


Arg Tyr Cys Tyr Leu Pro Glu Leu Leu Gln Thr Val Arg Leu Ala Leu 
225                 230                 235                 240 


Leu Pro Ala Ile Tyr Leu Met Glu Asn Val Ala Met Glu Glu Leu Ile 
                245                 250                 255     


Thr Lys Gln Arg Lys Ser Lys Glu Ile Val Glu Glu Ala Ile Arg Cys 
            260                 265                 270         


Lys Leu Lys Ile Leu Gln Asn Asp Gly Val Val Thr Ser Leu Cys Ala 
        275                 280                 285             


Arg Pro Arg Lys Thr Gly His Ala Leu Phe Leu Leu Gly Gly Gln Thr 
    290                 295                 300                 


Phe Met Cys Asp Lys Leu Tyr Leu Val Asp Gln Lys Ala Lys Glu Ile 
305                 310                 315                 320 


Ile Pro Lys Ala Asp Ile Pro Ser Pro Arg Lys Glu Phe Ser Ala Cys 
                325                 330                 335     


Ala Ile Gly Cys Lys Val Tyr Ile Thr Gly Gly Arg Gly Ser Glu Asn 
            340                 345                 350         


Gly Val Ser Lys Asp Val Trp Val Tyr Asp Thr Leu His Glu Glu Trp 
        355                 360                 365             


Ser Lys Ala Ala Pro Met Leu Val Ala Arg Phe Gly His Gly Ser Ala 
    370                 375                 380                 


Glu Leu Lys His Cys Leu Tyr Val Val Gly Gly His Thr Ala Ala Thr 
385                 390                 395                 400 


Gly Cys Leu Pro Ala Ser Pro Ser Val Ser Leu Lys Gln Val Glu His 
                405                 410                 415     


Tyr Asp Pro Thr Ile Asn Lys Trp Thr Met Val Ala Pro Leu Arg Glu 
            420                 425                 430         


Gly Val Ser Asn Ala Ala Val Val Ser Ala Lys Leu Lys Leu Phe Ala 
        435                 440                 445             


Phe Gly Gly Thr Ser Val Ser His Asp Lys Leu Pro Lys Val Gln Cys 
    450                 455                 460                 


Tyr Asp Gln Cys Glu Asn Arg Trp Thr Val Pro Ala Thr Cys Pro Gln 
465                 470                 475                 480 


Pro Trp Arg Tyr Thr Ala Ala Ala Val Leu Gly Asn Gln Ile Phe Ile 
                485                 490                 495     


Met Gly Gly Asp Thr Glu Phe Ser Ala Cys Ser Ala Tyr Lys Phe Asn 
            500                 505                 510         


Ser Glu Thr Tyr Gln Trp Thr Lys Val Gly Asp Val Thr Ala Lys Arg 
        515                 520                 525             


Met Ser Cys His Ala Val Ala Ser Gly Asn Lys Leu Tyr Val Val Gly 
    530                 535                 540                 


Gly Tyr Phe Gly Ile Gln Arg Cys Lys Thr Leu Asp Cys Tyr Asp Pro 
545                 550                 555                 560 


Thr Leu Asp Val Trp Asn Ser Ile Thr Thr Val Pro Tyr Ser Leu Ile 
                565                 570                 575     


Pro Thr Ala Phe Val Ser Thr Trp Lys His Leu Pro Ser 
            580                 585                 


<210>  3552
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENDOG__Homo_sapiens__NP_004426

<400>  3552

Met Arg Ala Leu Arg Ala Gly Leu Thr Leu Ala Ser Gly Ala Gly Leu 
1               5                   10                  15      


Gly Ala Val Val Glu Gly Trp Arg Arg Arg Arg Glu Asp Ala Arg Ala 
            20                  25                  30          


Ala Pro Gly Leu Leu Gly Arg Leu Pro Val Leu Pro Val Ala Ala Ala 
        35                  40                  45              


Ala Glu Leu Pro Pro Val Pro Gly Gly Pro Arg Gly Pro Gly Glu Leu 
    50                  55                  60                  


Ala Lys Tyr Gly Leu Pro Gly Leu Ala Gln Leu Lys Ser Arg Glu Ser 
65                  70                  75                  80  


Tyr Val Leu Cys Tyr Asp Pro Arg Thr Arg Gly Ala Leu Trp Val Val 
                85                  90                  95      


Glu Gln Leu Arg Pro Glu Arg Leu Arg Gly Asp Gly Asp Arg Arg Glu 
            100                 105                 110         


Cys Asp Phe Arg Glu Asp Asp Ser Val His Ala Tyr His Arg Ala Thr 
        115                 120                 125             


Asn Ala Asp Tyr Arg Gly Ser Gly Phe Asp Arg Gly His Leu Ala Ala 
    130                 135                 140                 


Ala Ala Asn His Arg Trp Ser Gln Lys Ala Met Asp Asp Thr Phe Tyr 
145                 150                 155                 160 


Leu Ser Asn Val Ala Pro Gln Val Pro His Leu Asn Gln Asn Ala Trp 
                165                 170                 175     


Asn Asn Leu Glu Lys Tyr Ser Arg Ser Leu Thr Arg Ser Tyr Gln Asn 
            180                 185                 190         


Val Tyr Val Cys Thr Gly Pro Leu Phe Leu Pro Arg Thr Glu Ala Asp 
        195                 200                 205             


Gly Lys Ser Tyr Val Lys Tyr Gln Val Ile Gly Lys Asn His Val Ala 
    210                 215                 220                 


Val Pro Thr His Phe Phe Lys Val Leu Ile Leu Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Gln Ile Glu Leu Arg Thr Tyr Val Met Pro Asn Ala Pro Val Asp Glu 
                245                 250                 255     


Ala Ile Pro Leu Glu Arg Phe Leu Val Pro Ile Glu Ser Ile Glu Arg 
            260                 265                 270         


Ala Ser Gly Leu Leu Phe Val Pro Asn Ile Leu Ala Arg Ala Gly Ser 
        275                 280                 285             


Leu Lys Ala Ile Thr Ala Gly Ser Lys 
    290                 295         


<210>  3553
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENDOU__Homo_sapiens__NP_001165910

<400>  3553

Met Arg Ala Cys Ile Ser Leu Val Leu Ala Val Leu Cys Gly Leu Ala 
1               5                   10                  15      


Trp Ala Gly Lys Ile Glu Ser Cys Ala Ser Arg Cys Asn Glu Lys Phe 
            20                  25                  30          


Asn Arg Asp Ala Ala Cys Gln Cys Asp Arg Arg Cys Leu Trp His Gly 
        35                  40                  45              


Asn Cys Cys Glu Asp Tyr Glu His Leu Cys Thr Glu Asp His Lys Glu 
    50                  55                  60                  


Ser Glu Pro Leu Pro Gln Leu Glu Glu Glu Thr Glu Glu Ala Leu Ala 
65                  70                  75                  80  


Ser Asn Leu Tyr Ser Ala Pro Thr Ser Cys Gln Gly Arg Cys Tyr Glu 
                85                  90                  95      


Ala Phe Asp Lys His His Gln Cys His Cys Asn Ala Arg Cys Gln Glu 
            100                 105                 110         


Phe Gly Asn Cys Cys Lys Asp Phe Glu Ser Leu Cys Ser Asp His Glu 
        115                 120                 125             


Val Ser His Ser Ser Asp Ala Ile Thr Lys Glu Glu Ile Gln Ser Ile 
    130                 135                 140                 


Ser Glu Lys Ile Tyr Arg Ala Asp Thr Asn Lys Ala Gln Lys Glu Asp 
145                 150                 155                 160 


Ile Val Leu Asn Ser Gln Asn Cys Ile Ser Pro Ser Glu Thr Arg Asn 
                165                 170                 175     


Gln Val Asp Arg Cys Pro Lys Pro Leu Phe Thr Tyr Val Asn Glu Lys 
            180                 185                 190         


Leu Phe Ser Lys Pro Thr Tyr Ala Ala Phe Ile Asn Leu Leu Asn Asn 
        195                 200                 205             


Tyr Gln Arg Ala Thr Gly His Gly Glu His Phe Ser Ala Gln Glu Leu 
    210                 215                 220                 


Ala Glu Gln Asp Ala Phe Leu Arg Glu Ile Met Lys Thr Ala Val Met 
225                 230                 235                 240 


Lys Glu Leu Tyr Ser Phe Leu His His Gln Asn Arg Tyr Gly Ser Glu 
                245                 250                 255     


Gln Glu Phe Val Asp Asp Leu Lys Asn Met Trp Phe Gly Leu Tyr Ser 
            260                 265                 270         


Arg Gly Asn Glu Glu Gly Asp Ser Ser Gly Phe Glu His Val Phe Ser 
        275                 280                 285             


Gly Glu Val Lys Lys Gly Lys Val Thr Gly Phe His Asn Trp Ile Arg 
    290                 295                 300                 


Phe Tyr Leu Glu Glu Lys Glu Gly Leu Val Asp Tyr Tyr Ser His Ile 
305                 310                 315                 320 


Tyr Asp Gly Pro Trp Asp Ser Tyr Pro Asp Val Leu Ala Met Gln Phe 
                325                 330                 335     


Asn Trp Asp Gly Tyr Tyr Lys Glu Val Gly Ser Ala Phe Ile Gly Ser 
            340                 345                 350         


Ser Pro Glu Phe Glu Phe Ala Leu Tyr Ser Leu Cys Phe Ile Ala Arg 
        355                 360                 365             


Pro Gly Lys Val Cys Gln Leu Ser Leu Gly Gly Tyr Pro Leu Ala Val 
    370                 375                 380                 


Arg Thr Tyr Thr Trp Asp Lys Ser Thr Tyr Gly Asn Gly Lys Lys Tyr 
385                 390                 395                 400 


Ile Ala Thr Ala Tyr Ile Val Ser Ser Thr 
                405                 410 


<210>  3554
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENDOV__Homo_sapiens__NP_001158109

<400>  3554

Met Ala Leu Glu Ala Ala Gly Gly Pro Pro Glu Glu Thr Leu Ser Leu 
1               5                   10                  15      


Trp Lys Arg Glu Gln Ala Arg Leu Lys Ala His Val Val Asp Arg Asp 
            20                  25                  30          


Thr Glu Ala Trp Gln Arg Asp Pro Ala Phe Ser Gly Leu Gln Arg Val 
        35                  40                  45              


Gly Gly Val Asp Val Ser Phe Val Lys Gly Asp Ser Val Arg Ala Cys 
    50                  55                  60                  


Ala Ser Leu Val Val Leu Ser Phe Pro Glu Leu Glu Val Leu Leu Val 
65                  70                  75                  80  


Asp Gly Asn Gly Val Leu His His Arg Gly Phe Gly Val Ala Cys His 
                85                  90                  95      


Leu Gly Val Leu Thr Asp Leu Pro Cys Val Gly Val Ala Lys Lys Leu 
            100                 105                 110         


Leu Gln Val Asp Gly Leu Glu Asn Asn Ala Leu His Lys Glu Lys Ile 
        115                 120                 125             


Arg Leu Leu Gln Thr Arg Gly Asp Ser Phe Pro Leu Leu Gly Asp Ser 
    130                 135                 140                 


Gly Thr Val Leu Gly Met Ala Leu Arg Ser His Asp Arg Ser Thr Arg 
145                 150                 155                 160 


Pro Leu Tyr Ile Ser Val Gly His Arg Met Ser Leu Glu Ala Ala Val 
                165                 170                 175     


Arg Leu Thr Cys Cys Cys Cys Arg Phe Arg Ile Pro Glu Pro Val Arg 
            180                 185                 190         


Gln Ala Asp Ile Cys Ser Arg Glu His Ile Arg Lys Ser Leu Gly Leu 
        195                 200                 205             


Pro Gly Pro Pro Thr Pro Arg Ser Pro Lys Ala Gln Arg Pro Val Ala 
    210                 215                 220                 


Cys Pro Lys Gly Asp Ser Gly Glu Ser Ser Ala Leu Cys 
225                 230                 235         


<210>  3555
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENGASE__Homo_sapiens__NP_001036038

<400>  3555

Met Glu Ala Ala Ala Val Thr Val Thr Arg Ser Ala Thr Arg Arg Arg 
1               5                   10                  15      


Arg Arg Gln Leu Gln Gly Leu Ala Ala Pro Glu Ala Gly Thr Gln Glu 
            20                  25                  30          


Glu Gln Glu Asp Gln Glu Pro Arg Pro Arg Arg Arg Arg Pro Gly Arg 
        35                  40                  45              


Ser Ile Lys Asp Glu Glu Glu Glu Thr Val Phe Arg Glu Val Val Ser 
    50                  55                  60                  


Phe Ser Pro Asp Pro Leu Pro Val Arg Tyr Tyr Asp Lys Asp Thr Thr 
65                  70                  75                  80  


Lys Pro Ile Ser Phe Tyr Leu Ser Ser Leu Glu Glu Leu Leu Ala Trp 
                85                  90                  95      


Lys Pro Arg Leu Glu Asp Gly Phe Asn Val Ala Leu Glu Pro Leu Ala 
            100                 105                 110         


Cys Arg Gln Pro Pro Leu Ser Ser Gln Arg Pro Arg Thr Leu Leu Cys 
        115                 120                 125             


His Asp Met Met Gly Gly Tyr Leu Asp Asp Arg Phe Ile Gln Gly Ser 
    130                 135                 140                 


Val Val Gln Thr Pro Tyr Ala Phe Tyr His Trp Gln Cys Ile Asp Val 
145                 150                 155                 160 


Phe Val Tyr Phe Ser His His Thr Val Thr Ile Pro Pro Val Gly Trp 
                165                 170                 175     


Thr Asn Thr Ala His Arg His Gly Val Cys Val Leu Gly Thr Phe Ile 
            180                 185                 190         


Thr Glu Trp Asn Glu Gly Gly Arg Leu Cys Glu Ala Phe Leu Ala Gly 
        195                 200                 205             


Asp Glu Arg Ser Tyr Gln Ala Val Ala Asp Arg Leu Val Gln Ile Thr 
    210                 215                 220                 


Gln Phe Phe Arg Phe Asp Gly Trp Leu Ile Asn Ile Glu Asn Ser Leu 
225                 230                 235                 240 


Ser Leu Ala Ala Val Gly Asn Met Pro Pro Phe Leu Arg Tyr Leu Thr 
                245                 250                 255     


Thr Gln Leu His Arg Gln Val Pro Gly Gly Leu Val Leu Trp Tyr Asp 
            260                 265                 270         


Ser Val Val Gln Ser Gly Gln Leu Lys Trp Gln Asp Glu Leu Asn Gln 
        275                 280                 285             


His Asn Arg Val Phe Phe Asp Ser Cys Asp Gly Phe Phe Thr Asn Tyr 
    290                 295                 300                 


Asn Trp Arg Glu Glu His Leu Glu Arg Met Leu Gly Gln Ala Gly Glu 
305                 310                 315                 320 


Arg Arg Ala Asp Val Tyr Val Gly Val Asp Val Phe Ala Arg Gly Asn 
                325                 330                 335     


Val Val Gly Gly Arg Phe Asp Thr Asp Lys Ser Leu Glu Leu Ile Arg 
            340                 345                 350         


Lys His Gly Phe Ser Val Ala Leu Phe Ala Pro Gly Trp Val Tyr Glu 
        355                 360                 365             


Cys Leu Glu Lys Lys Asp Phe Phe Gln Asn Gln Asp Lys Phe Trp Gly 
    370                 375                 380                 


Arg Leu Glu Arg Tyr Leu Pro Thr His Ser Ile Cys Ser Leu Pro Phe 
385                 390                 395                 400 


Val Thr Ser Phe Cys Leu Gly Met Gly Ala Arg Arg Val Cys Tyr Gly 
                405                 410                 415     


Gln Glu Glu Ala Val Gly Pro Trp Tyr His Leu Ser Ala Gln Glu Ile 
            420                 425                 430         


Gln Pro Leu Phe Gly Glu His Arg Leu Gly Gly Asp Gly Arg Gly Trp 
        435                 440                 445             


Val Arg Thr His Cys Cys Leu Glu Asp Ala Trp His Gly Gly Ser Ser 
    450                 455                 460                 


Leu Leu Val Arg Gly Val Ile Pro Pro Glu Val Gly Asn Val Ala Val 
465                 470                 475                 480 


Arg Leu Phe Ser Leu Gln Ala Pro Val Pro Pro Lys Ile Tyr Leu Ser 
                485                 490                 495     


Met Val Tyr Lys Leu Glu Gly Pro Thr Asp Val Thr Val Ala Leu Glu 
            500                 505                 510         


Leu Thr Thr Gly Asp Ala Gly Ser Cys His Ile Gly Gly Ile Ser Val 
        515                 520                 525             


Leu Asn Ala Glu Thr Ser Ser Arg His Ser Leu Arg Pro Leu Arg Val 
    530                 535                 540                 


Pro Pro Thr Lys Leu Ala Arg Trp Val Gly Arg Cys Gly Arg Gln Leu 
545                 550                 555                 560 


Ser Gly Gly Trp Val Gln His Cys Tyr Glu Val Ser Leu Arg Gly Cys 
                565                 570                 575     


Leu Leu Leu Asp Leu Leu Val Cys Phe Ser Arg Pro Pro Gly Ser Arg 
            580                 585                 590         


Glu Glu Glu Ser Phe Thr Cys Arg Leu Gly Glu Ile Gln Val Val Asp 
        595                 600                 605             


Ala Ala Ser Leu Leu Ala Pro Leu Pro Gln Val Gln Ala Val Thr Ile 
    610                 615                 620                 


Ser His Ile Arg Trp Gln Pro Ser Ala Ser Glu Arg Glu Gly Pro Pro 
625                 630                 635                 640 


Ala Leu Leu Gln Leu Ser Cys Thr Leu His Trp Ser Phe Leu Leu Ser 
                645                 650                 655     


Gln Val Arg Cys Phe Arg Ile His Cys Trp Gly Gly Met Ser Asp Asp 
            660                 665                 670         


Ser Pro Gly Arg Glu Leu Pro Arg Pro Glu Met Pro Met Phe Leu Gly 
        675                 680                 685             


Leu Ala Phe Ala Thr Gln Tyr Arg Ile Val Asp Leu Leu Val Glu Ala 
    690                 695                 700                 


Ala Gly Pro Gly Gln Asp Arg Arg Met Glu Phe Leu Val Glu Pro Val 
705                 710                 715                 720 


Pro Lys Glu Gly Phe Arg Val Pro Gln Ala Glu Trp Gly Arg Ala Val 
                725                 730                 735     


Leu Leu Tyr Ser Ala Pro Ala 
            740             


<210>  3556
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENG__Homo_sapiens__NP_000109

<400>  3556

Met Asp Arg Gly Thr Leu Pro Leu Ala Val Ala Leu Leu Leu Ala Ser 
1               5                   10                  15      


Cys Ser Leu Ser Pro Thr Ser Leu Ala Glu Thr Val His Cys Asp Leu 
            20                  25                  30          


Gln Pro Val Gly Pro Glu Arg Gly Glu Val Thr Tyr Thr Thr Ser Gln 
        35                  40                  45              


Val Ser Lys Gly Cys Val Ala Gln Ala Pro Asn Ala Ile Leu Glu Val 
    50                  55                  60                  


His Val Leu Phe Leu Glu Phe Pro Thr Gly Pro Ser Gln Leu Glu Leu 
65                  70                  75                  80  


Thr Leu Gln Ala Ser Lys Gln Asn Gly Thr Trp Pro Arg Glu Val Leu 
                85                  90                  95      


Leu Val Leu Ser Val Asn Ser Ser Val Phe Leu His Leu Gln Ala Leu 
            100                 105                 110         


Gly Ile Pro Leu His Leu Ala Tyr Asn Ser Ser Leu Val Thr Phe Gln 
        115                 120                 125             


Glu Pro Pro Gly Val Asn Thr Thr Glu Leu Pro Ser Phe Pro Lys Thr 
    130                 135                 140                 


Gln Ile Leu Glu Trp Ala Ala Glu Arg Gly Pro Ile Thr Ser Ala Ala 
145                 150                 155                 160 


Glu Leu Asn Asp Pro Gln Ser Ile Leu Leu Arg Leu Gly Gln Ala Gln 
                165                 170                 175     


Gly Ser Leu Ser Phe Cys Met Leu Glu Ala Ser Gln Asp Met Gly Arg 
            180                 185                 190         


Thr Leu Glu Trp Arg Pro Arg Thr Pro Ala Leu Val Arg Gly Cys His 
        195                 200                 205             


Leu Glu Gly Val Ala Gly His Lys Glu Ala His Ile Leu Arg Val Leu 
    210                 215                 220                 


Pro Gly His Ser Ala Gly Pro Arg Thr Val Thr Val Lys Val Glu Leu 
225                 230                 235                 240 


Ser Cys Ala Pro Gly Asp Leu Asp Ala Val Leu Ile Leu Gln Gly Pro 
                245                 250                 255     


Pro Tyr Val Ser Trp Leu Ile Asp Ala Asn His Asn Met Gln Ile Trp 
            260                 265                 270         


Thr Thr Gly Glu Tyr Ser Phe Lys Ile Phe Pro Glu Lys Asn Ile Arg 
        275                 280                 285             


Gly Phe Lys Leu Pro Asp Thr Pro Gln Gly Leu Leu Gly Glu Ala Arg 
    290                 295                 300                 


Met Leu Asn Ala Ser Ile Val Ala Ser Phe Val Glu Leu Pro Leu Ala 
305                 310                 315                 320 


Ser Ile Val Ser Leu His Ala Ser Ser Cys Gly Gly Arg Leu Gln Thr 
                325                 330                 335     


Ser Pro Ala Pro Ile Gln Thr Thr Pro Pro Lys Asp Thr Cys Ser Pro 
            340                 345                 350         


Glu Leu Leu Met Ser Leu Ile Gln Thr Lys Cys Ala Asp Asp Ala Met 
        355                 360                 365             


Thr Leu Val Leu Lys Lys Glu Leu Val Ala His Leu Lys Cys Thr Ile 
    370                 375                 380                 


Thr Gly Leu Thr Phe Trp Asp Pro Ser Cys Glu Ala Glu Asp Arg Gly 
385                 390                 395                 400 


Asp Lys Phe Val Leu Arg Ser Ala Tyr Ser Ser Cys Gly Met Gln Val 
                405                 410                 415     


Ser Ala Ser Met Ile Ser Asn Glu Ala Val Val Asn Ile Leu Ser Ser 
            420                 425                 430         


Ser Ser Pro Gln Arg Lys Lys Val His Cys Leu Asn Met Asp Ser Leu 
        435                 440                 445             


Ser Phe Gln Leu Gly Leu Tyr Leu Ser Pro His Phe Leu Gln Ala Ser 
    450                 455                 460                 


Asn Thr Ile Glu Pro Gly Gln Gln Ser Phe Val Gln Val Arg Val Ser 
465                 470                 475                 480 


Pro Ser Val Ser Glu Phe Leu Leu Gln Leu Asp Ser Cys His Leu Asp 
                485                 490                 495     


Leu Gly Pro Glu Gly Gly Thr Val Glu Leu Ile Gln Gly Arg Ala Ala 
            500                 505                 510         


Lys Gly Asn Cys Val Ser Leu Leu Ser Pro Ser Pro Glu Gly Asp Pro 
        515                 520                 525             


Arg Phe Ser Phe Leu Leu His Phe Tyr Thr Val Pro Ile Pro Lys Thr 
    530                 535                 540                 


Gly Thr Leu Ser Cys Thr Val Ala Leu Arg Pro Lys Thr Gly Ser Gln 
545                 550                 555                 560 


Asp Gln Glu Val His Arg Thr Val Phe Met Arg Leu Asn Ile Ile Ser 
                565                 570                 575     


Pro Asp Leu Ser Gly Cys Thr Ser Lys Gly Leu Val Leu Pro Ala Val 
            580                 585                 590         


Leu Gly Ile Thr Phe Gly Ala Phe Leu Ile Gly Ala Leu Leu Thr Ala 
        595                 600                 605             


Ala Leu Trp Tyr Ile Tyr Ser His Thr Arg Glu Tyr Pro Arg Pro Pro 
    610                 615                 620                 


Gln 
625 


<210>  3557
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENHO__Homo_sapiens__NP_940975

<400>  3557

Met Gly Ala Ala Ile Ser Gln Gly Ala Leu Ile Ala Ile Val Cys Asn 
1               5                   10                  15      


Gly Leu Val Gly Phe Leu Leu Leu Leu Leu Trp Val Ile Leu Cys Trp 
            20                  25                  30          


Ala Cys His Ser Arg Ser Ala Asp Val Asp Ser Leu Ser Glu Ser Ser 
        35                  40                  45              


Pro Asn Ser Ser Pro Gly Pro Cys Pro Glu Lys Ala Pro Pro Pro Gln 
    50                  55                  60                  


Lys Pro Ser His Glu Gly Ser Tyr Leu Leu Gln Pro 
65                  70                  75      


<210>  3558
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENO2__Homo_sapiens__NP_001966

<400>  3558

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  3559
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENO3__Homo_sapiens__NP_001180432

<400>  3559

Met Ala Met Gln Lys Ile Phe Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu His Thr Ala Lys Gly Arg Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gly Arg Tyr Leu Gly Lys Ala Lys Phe Gly 
    50                  55                  60                  


Ala Asn Ala Ile Leu Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala 
65                  70                  75                  80  


Ala Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly 
                85                  90                  95      


Asn Pro Asp Leu Ile Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly 
            100                 105                 110         


Gly Ser His Ala Gly Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu 
        115                 120                 125             


Pro Val Gly Ala Ser Ser Phe Lys Glu Ala Met Arg Ile Gly Ala Glu 
    130                 135                 140                 


Val Tyr His His Leu Lys Gly Val Ile Lys Ala Lys Tyr Gly Lys Asp 
145                 150                 155                 160 


Ala Thr Asn Val Gly Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu 
                165                 170                 175     


Asn Asn Glu Ala Leu Glu Leu Leu Lys Thr Ala Ile Gln Ala Ala Gly 
            180                 185                 190         


Tyr Pro Asp Lys Val Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe 
        195                 200                 205             


Tyr Arg Asn Gly Lys Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro 
    210                 215                 220                 


Ala Arg His Ile Thr Gly Glu Lys Leu Gly Glu Leu Tyr Lys Ser Phe 
225                 230                 235                 240 


Ile Lys Asn Tyr Pro Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp 
                245                 250                 255     


Asp Trp Ala Thr Trp Thr Ser Phe Leu Ser Gly Val Asn Ile Gln Ile 
            260                 265                 270         


Val Gly Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Gln Ala 
        275                 280                 285             


Val Glu Lys Lys Ala Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile 
    290                 295                 300                 


Gly Ser Val Thr Glu Ser Ile Gln Ala Cys Lys Leu Ala Gln Ser Asn 
305                 310                 315                 320 


Gly Trp Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr 
                325                 330                 335     


Phe Ile Ala Asp Leu Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr 
            340                 345                 350         


Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met 
        355                 360                 365             


Arg Ile Glu Glu Ala Leu Gly Asp Lys Ala Ile Phe Ala Gly Arg Lys 
    370                 375                 380                 


Phe Arg Asn Pro Lys Ala Lys 
385                 390     


<210>  3560
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENO4__Homo_sapiens__NP_001229628

<400>  3560

Met Glu Glu Glu Gly Gly Gly Arg Ser Cys Gly Thr Thr Arg Glu Leu 
1               5                   10                  15      


Gln Lys Leu Lys Gln Gln Ala Met Glu Tyr Tyr Arg Glu Asn Asp Val 
            20                  25                  30          


Pro Arg Arg Leu Glu Glu Leu Leu Asn Ser Thr Phe Tyr Leu Gln Pro 
        35                  40                  45              


Ala Asp Val Tyr Gly His Leu Ala Asn Cys Phe Ser Lys Leu Ala Lys 
    50                  55                  60                  


Pro Pro Thr Ile Cys Lys Ile Val Gly Lys Asp Val Leu Asp Gly Leu 
65                  70                  75                  80  


Gly Leu Pro Thr Leu Gln Val Asp Ile Phe Cys Thr Ile Gln Asn Phe 
                85                  90                  95      


Pro Lys Asn Val Cys Ser Val Val Ile Ser Thr His Phe Glu Val His 
            100                 105                 110         


Glu Asn Ala Leu Pro Glu Leu Ala Lys Ala Glu Glu Ala Glu Arg Ala 
        115                 120                 125             


Ser Ala Val Ser Thr Ala Val Gln Trp Val Asn Ser Thr Ile Thr His 
    130                 135                 140                 


Glu Leu Gln Gly Met Ala Pro Ser Asp Gln Ala Glu Val Asp His Leu 
145                 150                 155                 160 


Leu Arg Ile Phe Phe Ala Ser Lys Val Gln Glu Asp Lys Gly Arg Lys 
                165                 170                 175     


Glu Leu Glu Lys Ser Leu Glu Tyr Ser Thr Val Pro Thr Pro Leu Pro 
            180                 185                 190         


Pro Val Pro Pro Pro Pro Pro Pro Pro Pro Pro Thr Lys Lys Lys Gly 
        195                 200                 205             


Gln Lys Pro Gly Arg Lys Asp Thr Ile Thr Glu Lys Pro Ile Ala Pro 
    210                 215                 220                 


Ala Glu Pro Val Glu Pro Val Leu Ser Gly Ser Met Ala Ile Gly Ala 
225                 230                 235                 240 


Val Ser Leu Ala Val Ala Lys Ala Cys Ala Met Leu Leu Asn Lys Pro 
                245                 250                 255     


Leu Tyr Leu Asn Ile Ala Leu Leu Lys His Asn Gln Glu Gln Pro Thr 
            260                 265                 270         


Thr Leu Ser Met Pro Leu Leu Met Val Ser Leu Val Ser Cys Gly Lys 
        275                 280                 285             


Ser Ser Ser Gly Lys Leu Asn Leu Met Lys Glu Val Ile Cys Ile Pro 
    290                 295                 300                 


His Pro Glu Leu Thr Thr Lys Gln Gly Val Glu Met Leu Met Glu Met 
305                 310                 315                 320 


Gln Lys His Ile Asn Lys Ile Ile Glu Met Pro Ser Pro Pro Lys Ala 
                325                 330                 335     


Glu Thr Lys Lys Gly His Asp Gly Ser Lys Arg Gly Gln Gln Gln Ile 
            340                 345                 350         


Thr Gly Lys Met Ser His Leu Gly Cys Leu Thr Ile Asn Cys Asp Ser 
        355                 360                 365             


Ile Glu Gln Pro Leu Leu Leu Ile Gln Glu Ile Cys Ala Asn Leu Gly 
    370                 375                 380                 


Leu Glu Leu Gly Thr Asn Leu His Leu Ala Ile Asn Cys Ala Gly His 
385                 390                 395                 400 


Glu Leu Met Asp Tyr Asn Lys Gly Lys Tyr Glu Val Ile Met Gly Thr 
                405                 410                 415     


Tyr Lys Asn Ala Ala Glu Met Val Asp Leu Tyr Val Asp Leu Ile Asn 
            420                 425                 430         


Lys Tyr Pro Ser Ile Ile Ala Leu Ile Asp Pro Phe Arg Lys Glu Asp 
        435                 440                 445             


Ser Glu Gln Trp Asp Ser Ile Tyr His Ala Leu Gly Ser Arg Cys Tyr 
    450                 455                 460                 


Ile Ile Ala Gly Thr Ala Ser Lys Ser Ile Ser Lys Leu Leu Glu Gln 
465                 470                 475                 480 


Gly Asn Ile Ser Ile Pro Lys Ser Asn Gly Leu Ile Ile Lys His Thr 
                485                 490                 495     


Asn Gln Thr Thr Met Ser Asp Leu Val Glu Ile Thr Asn Leu Ile Asp 
            500                 505                 510         


Ser Lys Lys His Ile Thr Val Phe Gly Ser Thr Glu Gly Glu Ser Ser 
        515                 520                 525             


Asp Asp Ser Leu Val Asp Leu Ala Val Gly Leu Gly Val Arg Phe Ile 
    530                 535                 540                 


Lys Leu Gly Gly Leu Ser Arg Gly Glu Arg Val Thr Lys Tyr Asn Arg 
545                 550                 555                 560 


Leu Leu Thr Ile Glu Glu Glu Leu Val Gln Asn Gly Thr Leu Gly Phe 
                565                 570                 575     


Lys Glu Glu His Thr Phe Phe Tyr Phe Asn Glu Glu Ala Glu Lys Ala 
            580                 585                 590         


Ala Glu Ala Leu Glu Ala Ala Ala Ala Arg Glu Pro Leu Val Pro Thr 
        595                 600                 605             


Phe Pro Thr Gln Gly Val Glu Glu Ser Ala Glu Thr Gly Ala Ser Ser 
    610                 615                 620                 


Gly 
625 


<210>  3561
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENOPH1__Homo_sapiens__NP_067027

<400>  3561

Met Val Val Leu Ser Val Pro Ala Glu Val Thr Val Ile Leu Leu Asp 
1               5                   10                  15      


Ile Glu Gly Thr Thr Thr Pro Ile Ala Phe Val Lys Asp Ile Leu Phe 
            20                  25                  30          


Pro Tyr Ile Glu Glu Asn Val Lys Glu Tyr Leu Gln Thr His Trp Glu 
        35                  40                  45              


Glu Glu Glu Cys Gln Gln Asp Val Ser Leu Leu Arg Lys Gln Ala Glu 
    50                  55                  60                  


Glu Asp Ala His Leu Asp Gly Ala Val Pro Ile Pro Ala Ala Ser Gly 
65                  70                  75                  80  


Asn Gly Val Asp Asp Leu Gln Gln Met Ile Gln Ala Val Val Asp Asn 
                85                  90                  95      


Val Cys Trp Gln Met Ser Leu Asp Arg Lys Thr Thr Ala Leu Lys Gln 
            100                 105                 110         


Leu Gln Gly His Met Trp Arg Ala Ala Phe Thr Ala Gly Arg Met Lys 
        115                 120                 125             


Ala Glu Phe Phe Ala Asp Val Val Pro Ala Val Arg Lys Trp Arg Glu 
    130                 135                 140                 


Ala Gly Met Lys Val Tyr Ile Tyr Ser Ser Gly Ser Val Glu Ala Gln 
145                 150                 155                 160 


Lys Leu Leu Phe Gly His Ser Thr Glu Gly Asp Ile Leu Glu Leu Val 
                165                 170                 175     


Asp Gly His Phe Asp Thr Lys Ile Gly His Lys Val Glu Ser Glu Ser 
            180                 185                 190         


Tyr Arg Lys Ile Ala Asp Ser Ile Gly Cys Ser Thr Asn Asn Ile Leu 
        195                 200                 205             


Phe Leu Thr Asp Val Thr Arg Glu Ala Ser Ala Ala Glu Glu Ala Asp 
    210                 215                 220                 


Val His Val Ala Val Val Val Arg Pro Gly Asn Ala Gly Leu Thr Asp 
225                 230                 235                 240 


Asp Glu Lys Thr Tyr Tyr Ser Leu Ile Thr Ser Phe Ser Glu Leu Tyr 
                245                 250                 255     


Leu Pro Ser Ser Thr 
            260     


<210>  3562
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENOSF1__Homo_sapiens__NP_001119595

<400>  3562

Met Gln Lys Met Glu Ser Arg Gly Val Glu Leu Pro Ser Leu Trp Glu 
1               5                   10                  15      


Lys Ala Leu Lys Leu Ile Gly Pro Glu Lys Gly Val Val His Leu Ala 
            20                  25                  30          


Thr Ala Ala Val Leu Asn Ala Val Trp Asp Leu Trp Ala Lys Gln Glu 
        35                  40                  45              


Gly Lys Pro Val Trp Lys Leu Leu Val Asp Met Asp Pro Arg Met Leu 
    50                  55                  60                  


Val Ser Cys Ile Asp Phe Arg Tyr Ile Thr Asp Val Leu Thr Glu Glu 
65                  70                  75                  80  


Asp Ala Leu Glu Ile Leu Gln Lys Gly Gln Ile Gly Lys Lys Glu Arg 
                85                  90                  95      


Glu Lys Gln Met Leu Ala Gln Gly Tyr Pro Ala Tyr Thr Thr Ser Cys 
            100                 105                 110         


Ala Trp Leu Gly Tyr Ser Asp Asp Thr Leu Lys Gln Leu Cys Ala Gln 
        115                 120                 125             


Ala Leu Lys Asp Gly Trp Thr Arg Phe Lys Val Lys Val Gly Ala Asp 
    130                 135                 140                 


Leu Gln Asp Asp Met Arg Arg Cys Gln Ile Ile Arg Asp Met Ile Gly 
145                 150                 155                 160 


Pro Glu Lys Thr Leu Met Met Asp Ala Asn Gln Arg Trp Asp Val Pro 
                165                 170                 175     


Glu Ala Val Glu Trp Met Ser Lys Leu Ala Lys Phe Lys Pro Leu Trp 
            180                 185                 190         


Ile Glu Glu Pro Thr Ser Pro Asp Asp Ile Leu Gly His Ala Thr Ile 
        195                 200                 205             


Ser Lys Ala Leu Val Pro Leu Gly Ile Gly Ile Ala Thr Gly Glu Gln 
    210                 215                 220                 


Cys His Asn Arg Val Ile Phe Lys Gln Leu Leu Gln Ala Lys Ala Leu 
225                 230                 235                 240 


Gln Phe Leu Gln Ile Asp Ser Cys Arg Leu Gly Ser Val Asn Glu Asn 
                245                 250                 255     


Leu Ser Val Leu Leu Met Ala Lys Lys Phe Glu Ile Pro Val Cys Pro 
            260                 265                 270         


His Ala Gly Gly Val Gly Leu Cys Glu Leu Val Gln His Leu Ile Ile 
        275                 280                 285             


Phe Asp Tyr Ile Ser Val Ser Ala Ser Leu Glu Asn Arg Val Cys Glu 
    290                 295                 300                 


Tyr Val Asp His Leu His Glu His Phe Lys Tyr Pro Val Met Ile Gln 
305                 310                 315                 320 


Arg Ala Ser Tyr Met Pro Pro Lys Asp Pro Gly Tyr Ser Thr Glu Met 
                325                 330                 335     


Lys Glu Glu Ser Val Lys Lys His Gln Tyr Pro Asp Gly Glu Val Trp 
            340                 345                 350         


Lys Lys Leu Leu Pro Ala Gln Glu Asn 
        355                 360     


<210>  3563
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENOX1__Homo_sapiens__NP_001121087

<400>  3563

Met Val Asp Ala Gly Gly Val Glu Asn Ile Thr Gln Leu Pro Gln Glu 
1               5                   10                  15      


Leu Pro Gln Met Met Ala Ala Ala Ala Asp Gly Leu Gly Ser Ile Ala 
            20                  25                  30          


Ile Asp Thr Thr Gln Leu Asn Met Ser Val Thr Asp Pro Thr Ala Trp 
        35                  40                  45              


Ala Thr Ala Met Asn Asn Leu Gly Met Val Pro Val Gly Leu Pro Gly 
    50                  55                  60                  


Gln Gln Leu Val Ser Asp Ser Ile Cys Val Pro Gly Phe Asp Pro Ser 
65                  70                  75                  80  


Leu Asn Met Met Thr Gly Ile Thr Pro Ile Asn Pro Met Ile Pro Gly 
                85                  90                  95      


Leu Gly Leu Val Pro Pro Pro Pro Pro Thr Glu Val Ala Val Val Lys 
            100                 105                 110         


Glu Ile Ile His Cys Lys Ser Cys Thr Leu Phe Pro Gln Asn Pro Asn 
        115                 120                 125             


Leu Pro Pro Pro Ser Thr Arg Glu Arg Pro Pro Gly Cys Lys Thr Val 
    130                 135                 140                 


Phe Val Gly Gly Leu Pro Glu Asn Ala Thr Glu Glu Ile Ile Gln Glu 
145                 150                 155                 160 


Val Phe Glu Gln Cys Gly Asp Ile Thr Ala Ile Arg Lys Ser Lys Lys 
                165                 170                 175     


Asn Phe Cys His Ile Arg Phe Ala Glu Glu Phe Met Val Asp Lys Ala 
            180                 185                 190         


Ile Tyr Leu Ser Gly Tyr Arg Met Arg Leu Gly Ser Ser Thr Asp Lys 
        195                 200                 205             


Lys Asp Ser Gly Arg Leu His Val Asp Phe Ala Gln Ala Arg Asp Asp 
    210                 215                 220                 


Phe Tyr Glu Trp Glu Cys Lys Gln Arg Met Arg Ala Arg Glu Glu Arg 
225                 230                 235                 240 


His Arg Arg Lys Leu Glu Glu Asp Arg Leu Arg Pro Pro Ser Pro Pro 
                245                 250                 255     


Ala Ile Met His Tyr Ser Glu His Glu Ala Ala Leu Leu Ala Glu Lys 
            260                 265                 270         


Leu Lys Asp Asp Ser Lys Phe Ser Glu Ala Ile Thr Val Leu Leu Ser 
        275                 280                 285             


Trp Ile Glu Arg Gly Glu Val Asn Arg Arg Ser Ala Asn Gln Phe Tyr 
    290                 295                 300                 


Ser Met Val Gln Ser Ala Asn Ser His Val Arg Arg Leu Met Asn Glu 
305                 310                 315                 320 


Lys Ala Thr His Glu Gln Glu Met Glu Glu Ala Lys Glu Asn Phe Lys 
                325                 330                 335     


Asn Ala Leu Thr Gly Ile Leu Thr Gln Phe Glu Gln Ile Val Ala Val 
            340                 345                 350         


Phe Asn Ala Ser Thr Arg Gln Lys Ala Trp Asp His Phe Ser Lys Ala 
        355                 360                 365             


Gln Arg Lys Asn Ile Asp Ile Trp Arg Lys His Ser Glu Glu Leu Arg 
    370                 375                 380                 


Asn Ala Gln Ser Glu Gln Leu Met Gly Ile Arg Arg Glu Glu Glu Met 
385                 390                 395                 400 


Glu Met Ser Asp Asp Glu Asn Cys Asp Ser Pro Thr Lys Lys Met Arg 
                405                 410                 415     


Val Asp Glu Ser Ala Leu Ala Ala Gln Ala Tyr Ala Leu Lys Glu Glu 
            420                 425                 430         


Asn Asp Ser Leu Arg Trp Gln Leu Asp Ala Tyr Arg Asn Glu Val Glu 
        435                 440                 445             


Leu Leu Lys Gln Glu Lys Glu Gln Leu Phe Arg Thr Glu Glu Asn Leu 
    450                 455                 460                 


Thr Lys Asp Gln Gln Leu Gln Phe Leu Gln Gln Thr Met Gln Gly Met 
465                 470                 475                 480 


Gln Gln Gln Leu Leu Thr Ile Gln Glu Glu Leu Asn Asn Lys Lys Ser 
                485                 490                 495     


Glu Leu Glu Gln Ala Lys Glu Glu Gln Ser His Thr Gln Ala Leu Leu 
            500                 505                 510         


Lys Val Leu Gln Glu Gln Leu Lys Gly Thr Lys Glu Leu Val Glu Thr 
        515                 520                 525             


Asn Gly His Ser His Glu Asp Ser Asn Glu Ile Asn Val Leu Thr Val 
    530                 535                 540                 


Ala Leu Val Asn Gln Asp Arg Glu Asn Asn Ile Glu Lys Arg Ser Gln 
545                 550                 555                 560 


Gly Leu Lys Ser Glu Lys Glu Ala Leu Leu Ile Gly Ile Ile Ser Thr 
                565                 570                 575     


Phe Leu His Val His Pro Phe Gly Ala Asn Ile Glu Tyr Leu Trp Ser 
            580                 585                 590         


Tyr Met Gln Gln Leu Asp Ser Lys Ile Ser Ala Asn Glu Ile Glu Met 
        595                 600                 605             


Leu Leu Met Arg Leu Pro Arg Met Phe Lys Gln Glu Phe Thr Gly Val 
    610                 615                 620                 


Gly Ala Thr Leu Glu Lys Arg Trp Lys Leu Cys Ala Phe Glu Gly Ile 
625                 630                 635                 640 


Lys Thr Thr 
            


<210>  3564
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENOX2__Homo_sapiens__XP_011529546

<400>  3564

Met Leu His Ile Asn Gln Leu Leu Leu Cys Asn Gly Thr Ala Ser Ala 
1               5                   10                  15      


Ala Thr Asn Lys Asp Glu Thr Asn Cys Asn Phe Leu Ile Ser Ser Gly 
            20                  25                  30          


Leu Asn Gln Leu Pro Phe Asp Pro Ala Asn Asn Asn Glu Pro Leu Gln 
        35                  40                  45              


Phe Gly Ser Ala Ser Gly Pro Leu Val Thr Glu Gly Leu Ile Glu Asn 
    50                  55                  60                  


Gly Gly Glu Ser Ser Lys Lys Arg Lys Arg Thr Asn Thr Pro Ser Ala 
65                  70                  75                  80  


Asp Asn Ser Arg Thr Leu Asn Val Asp Ser Thr Ala Met Thr Leu Pro 
                85                  90                  95      


Met Ser Asp Pro Thr Ala Trp Ala Thr Ala Met Asn Asn Leu Gly Met 
            100                 105                 110         


Ala Pro Leu Gly Ile Ala Gly Gln Pro Ile Leu Pro Asp Phe Asp Pro 
        115                 120                 125             


Ala Leu Gly Met Met Thr Gly Ile Pro Pro Ile Thr Pro Met Met Pro 
    130                 135                 140                 


Gly Leu Gly Ile Val Pro Pro Pro Ile Pro Pro Asp Met Pro Val Val 
145                 150                 155                 160 


Lys Glu Ile Ile His Cys Lys Ser Cys Thr Leu Phe Pro Pro Asn Pro 
                165                 170                 175     


Asn Leu Pro Pro Pro Ala Thr Arg Glu Arg Pro Pro Gly Cys Lys Thr 
            180                 185                 190         


Val Phe Val Gly Gly Leu Pro Glu Asn Gly Thr Glu Gln Ile Ile Val 
        195                 200                 205             


Glu Val Phe Glu Gln Cys Gly Glu Ile Ile Ala Ile Arg Lys Ser Lys 
    210                 215                 220                 


Lys Asn Phe Cys His Ile Arg Phe Ala Glu Glu Tyr Met Val Asp Lys 
225                 230                 235                 240 


Ala Leu Tyr Leu Ser Gly Tyr Arg Ile Arg Leu Gly Ser Ser Thr Asp 
                245                 250                 255     


Lys Lys Asp Thr Gly Arg Leu His Val Asp Phe Ala Gln Ala Arg Asp 
            260                 265                 270         


Asp Leu Tyr Glu Trp Glu Cys Lys Gln Arg Met Leu Ala Arg Glu Glu 
        275                 280                 285             


Arg His Arg Arg Arg Met Glu Glu Glu Arg Leu Arg Pro Pro Ser Pro 
    290                 295                 300                 


Pro Pro Val Val His Tyr Ser Asp His Glu Cys Ser Ile Val Ala Glu 
305                 310                 315                 320 


Lys Leu Lys Asp Asp Ser Lys Phe Ser Glu Ala Val Gln Thr Leu Leu 
                325                 330                 335     


Thr Trp Ile Glu Arg Gly Glu Val Asn Arg Arg Ser Ala Asn Asn Phe 
            340                 345                 350         


Tyr Ser Met Ile Gln Ser Ala Asn Ser His Val Arg Arg Leu Val Asn 
        355                 360                 365             


Glu Lys Ala Ala His Glu Lys Asp Met Glu Glu Ala Lys Glu Lys Phe 
    370                 375                 380                 


Lys Gln Ala Leu Ser Gly Ile Leu Ile Gln Phe Glu Gln Ile Val Ala 
385                 390                 395                 400 


Val Tyr His Ser Ala Ser Lys Gln Lys Ala Trp Asp His Phe Thr Lys 
                405                 410                 415     


Ala Gln Arg Lys Asn Ile Ser Val Trp Cys Lys Gln Ala Glu Glu Ile 
            420                 425                 430         


Arg Asn Ile His Asn Asp Glu Leu Met Gly Ile Arg Arg Glu Glu Glu 
        435                 440                 445             


Met Glu Met Ser Asp Asp Glu Ile Glu Glu Met Thr Glu Thr Lys Glu 
    450                 455                 460                 


Thr Glu Glu Ser Ala Leu Val Ser Gln Ala Glu Ala Leu Lys Glu Glu 
465                 470                 475                 480 


Asn Asp Ser Leu Arg Trp Gln Leu Asp Ala Tyr Arg Asn Glu Val Glu 
                485                 490                 495     


Leu Leu Lys Gln Glu Gln Gly Lys Val His Arg Glu Asp Asp Pro Asn 
            500                 505                 510         


Lys Glu Gln Gln Leu Lys Leu Leu Gln Gln Ala Leu Gln Gly Met Gln 
        515                 520                 525             


Gln His Leu Leu Lys Val Gln Glu Glu Tyr Lys Lys Lys Glu Ala Glu 
    530                 535                 540                 


Leu Glu Lys Leu Lys Asp Asp Lys Leu Gln Val Glu Lys Met Leu Glu 
545                 550                 555                 560 


Asn Leu Lys Glu Lys Glu Ser Cys Ala Ser Arg Leu Cys Ala Ser Asn 
                565                 570                 575     


Gln Asp Ser Glu Tyr Pro Leu Glu Lys Thr Met Asn Ser Ser Pro Ile 
            580                 585                 590         


Lys Ser Glu Arg Glu Ala Leu Leu Val Gly Ile Ile Ser Thr Phe Leu 
        595                 600                 605             


His Val His Pro Phe Gly Ala Ser Ile Glu Tyr Ile Cys Ser Tyr Leu 
    610                 615                 620                 


His Arg Leu Asp Asn Lys Ile Cys Thr Ser Asp Val Glu Cys Leu Met 
625                 630                 635                 640 


Gly Arg Leu Gln His Thr Phe Lys Gln Glu Met Thr Gly Val Gly Ala 
                645                 650                 655     


Ser Leu Glu Lys Arg Trp Lys Phe Cys Gly Phe Glu Gly Leu Lys Leu 
            660                 665                 670         


Thr 
    


<210>  3565
<211>  957
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPEP__Homo_sapiens__NP_001968

<400>  3565

Met Asn Phe Ala Glu Arg Glu Gly Ser Lys Arg Tyr Cys Ile Gln Thr 
1               5                   10                  15      


Lys His Val Ala Ile Leu Cys Ala Val Val Val Gly Val Gly Leu Ile 
            20                  25                  30          


Val Gly Leu Ala Val Gly Leu Thr Arg Ser Cys Asp Ser Ser Gly Asp 
        35                  40                  45              


Gly Gly Pro Gly Thr Ala Pro Ala Pro Ser His Leu Pro Ser Ser Thr 
    50                  55                  60                  


Ala Ser Pro Ser Gly Pro Pro Ala Gln Asp Gln Asp Ile Cys Pro Ala 
65                  70                  75                  80  


Ser Glu Asp Glu Ser Gly Gln Trp Lys Asn Phe Arg Leu Pro Asp Phe 
                85                  90                  95      


Val Asn Pro Val His Tyr Asp Leu His Val Lys Pro Leu Leu Glu Glu 
            100                 105                 110         


Asp Thr Tyr Thr Gly Thr Val Ser Ile Ser Ile Asn Leu Ser Ala Pro 
        115                 120                 125             


Thr Arg Tyr Leu Trp Leu His Leu Arg Glu Thr Arg Ile Thr Arg Leu 
    130                 135                 140                 


Pro Glu Leu Lys Arg Pro Ser Gly Asp Gln Val Gln Val Arg Arg Cys 
145                 150                 155                 160 


Phe Glu Tyr Lys Lys Gln Glu Tyr Val Val Val Glu Ala Glu Glu Glu 
                165                 170                 175     


Leu Thr Pro Ser Ser Gly Asp Gly Leu Tyr Leu Leu Thr Met Glu Phe 
            180                 185                 190         


Ala Gly Trp Leu Asn Gly Ser Leu Val Gly Phe Tyr Arg Thr Thr Tyr 
        195                 200                 205             


Thr Glu Asn Gly Gln Val Lys Ser Ile Val Ala Thr Asp His Glu Pro 
    210                 215                 220                 


Thr Asp Ala Arg Lys Ser Phe Pro Cys Phe Asp Glu Pro Asn Lys Lys 
225                 230                 235                 240 


Ala Thr Tyr Thr Ile Ser Ile Thr His Pro Lys Glu Tyr Gly Ala Leu 
                245                 250                 255     


Ser Asn Met Pro Val Ala Lys Glu Glu Ser Val Asp Asp Lys Trp Thr 
            260                 265                 270         


Arg Thr Thr Phe Glu Lys Ser Val Pro Met Ser Thr Tyr Leu Val Cys 
        275                 280                 285             


Phe Ala Val His Gln Phe Asp Ser Val Lys Arg Ile Ser Asn Ser Gly 
    290                 295                 300                 


Lys Pro Leu Thr Ile Tyr Val Gln Pro Glu Gln Lys His Thr Ala Glu 
305                 310                 315                 320 


Tyr Ala Ala Asn Ile Thr Lys Ser Val Phe Asp Tyr Phe Glu Glu Tyr 
                325                 330                 335     


Phe Ala Met Asn Tyr Ser Leu Pro Lys Leu Asp Lys Ile Ala Ile Pro 
            340                 345                 350         


Asp Phe Gly Thr Gly Ala Met Glu Asn Trp Gly Leu Ile Thr Tyr Arg 
        355                 360                 365             


Glu Thr Asn Leu Leu Tyr Asp Pro Lys Glu Ser Ala Ser Ser Asn Gln 
    370                 375                 380                 


Gln Arg Val Ala Thr Val Val Ala His Glu Leu Val His Gln Trp Phe 
385                 390                 395                 400 


Gly Asn Ile Val Thr Met Asp Trp Trp Glu Asp Leu Trp Leu Asn Glu 
                405                 410                 415     


Gly Phe Ala Ser Phe Phe Glu Phe Leu Gly Val Asn His Ala Glu Thr 
            420                 425                 430         


Asp Trp Gln Met Arg Asp Gln Met Leu Leu Glu Asp Val Leu Pro Val 
        435                 440                 445             


Gln Glu Asp Asp Ser Leu Met Ser Ser His Pro Ile Ile Val Thr Val 
    450                 455                 460                 


Thr Thr Pro Asp Glu Ile Thr Ser Val Phe Asp Gly Ile Ser Tyr Ser 
465                 470                 475                 480 


Lys Gly Ser Ser Ile Leu Arg Met Leu Glu Asp Trp Ile Lys Pro Glu 
                485                 490                 495     


Asn Phe Gln Lys Gly Cys Gln Met Tyr Leu Glu Lys Tyr Gln Phe Lys 
            500                 505                 510         


Asn Ala Lys Thr Ser Asp Phe Trp Ala Ala Leu Glu Glu Ala Ser Arg 
        515                 520                 525             


Leu Pro Val Lys Glu Val Met Asp Thr Trp Thr Arg Gln Met Gly Tyr 
    530                 535                 540                 


Pro Val Leu Asn Val Asn Gly Val Lys Asn Ile Thr Gln Lys Arg Phe 
545                 550                 555                 560 


Leu Leu Asp Pro Arg Ala Asn Pro Ser Gln Pro Pro Ser Asp Leu Gly 
                565                 570                 575     


Tyr Thr Trp Asn Ile Pro Val Lys Trp Thr Glu Asp Asn Ile Thr Ser 
            580                 585                 590         


Ser Val Leu Phe Asn Arg Ser Glu Lys Glu Gly Ile Thr Leu Asn Ser 
        595                 600                 605             


Ser Asn Pro Ser Gly Asn Ala Phe Leu Lys Ile Asn Pro Asp His Ile 
    610                 615                 620                 


Gly Phe Tyr Arg Val Asn Tyr Glu Val Ala Thr Trp Asp Ser Ile Ala 
625                 630                 635                 640 


Thr Ala Leu Ser Leu Asn His Lys Thr Phe Ser Ser Ala Asp Arg Ala 
                645                 650                 655     


Ser Leu Ile Asp Asp Ala Phe Ala Leu Ala Arg Ala Gln Leu Leu Asp 
            660                 665                 670         


Tyr Lys Val Ala Leu Asn Leu Thr Lys Tyr Leu Lys Arg Glu Glu Asn 
        675                 680                 685             


Phe Leu Pro Trp Gln Arg Val Ile Ser Ala Val Thr Tyr Ile Ile Ser 
    690                 695                 700                 


Met Phe Glu Asp Asp Lys Glu Leu Tyr Pro Met Ile Glu Glu Tyr Phe 
705                 710                 715                 720 


Gln Gly Gln Val Lys Pro Ile Ala Asp Ser Leu Gly Trp Asn Asp Ala 
                725                 730                 735     


Gly Asp His Val Thr Lys Leu Leu Arg Ser Ser Val Leu Gly Phe Ala 
            740                 745                 750         


Cys Lys Met Gly Asp Arg Glu Ala Leu Asn Asn Ala Ser Ser Leu Phe 
        755                 760                 765             


Glu Gln Trp Leu Asn Gly Thr Val Ser Leu Pro Val Asn Leu Arg Leu 
    770                 775                 780                 


Leu Val Tyr Arg Tyr Gly Met Gln Asn Ser Gly Asn Glu Ile Ser Trp 
785                 790                 795                 800 


Asn Tyr Thr Leu Glu Gln Tyr Gln Lys Thr Ser Leu Ala Gln Glu Lys 
                805                 810                 815     


Glu Lys Leu Leu Tyr Gly Leu Ala Ser Val Lys Asn Val Thr Leu Leu 
            820                 825                 830         


Ser Arg Tyr Leu Asp Leu Leu Lys Asp Thr Asn Leu Ile Lys Thr Gln 
        835                 840                 845             


Asp Val Phe Thr Val Ile Arg Tyr Ile Ser Tyr Asn Ser Tyr Gly Lys 
    850                 855                 860                 


Asn Met Ala Trp Asn Trp Ile Gln Leu Asn Trp Asp Tyr Leu Val Asn 
865                 870                 875                 880 


Arg Tyr Thr Leu Asn Asn Arg Asn Leu Gly Arg Ile Val Thr Ile Ala 
                885                 890                 895     


Glu Pro Phe Asn Thr Glu Leu Gln Leu Trp Gln Met Glu Ser Phe Phe 
            900                 905                 910         


Ala Lys Tyr Pro Gln Ala Gly Ala Gly Glu Lys Pro Arg Glu Gln Val 
        915                 920                 925             


Leu Glu Thr Val Lys Asn Asn Ile Glu Trp Leu Lys Gln His Arg Asn 
    930                 935                 940                 


Thr Ile Arg Glu Trp Phe Phe Asn Leu Leu Glu Ser Gly 
945                 950                 955         


<210>  3566
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP1__Homo_sapiens__NP_006199

<400>  3566

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  3567
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP2__Homo_sapiens__NP_001035181

<400>  3567

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr 
        595                 600                 605             


Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu 
    610                 615                 620                 


Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Ser Lys Gln Ala 
625                 630                 635                 640 


Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys Val Arg Pro Asp 
                645                 650                 655     


Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn 
            660                 665                 670         


Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser 
        675                 680                 685             


Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro 
    690                 695                 700                 


Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe Gln Arg Val Leu 
705                 710                 715                 720 


Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly 
                725                 730                 735     


Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp Thr Glu Asp Lys 
            740                 745                 750         


Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr 
        755                 760                 765             


Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys 
    770                 775                 780                 


Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro 
785                 790                 795                 800 


Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val 
                805                 810                 815     


Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His 
            820                 825                 830         


Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg Ser Tyr Pro Glu 
        835                 840                 845             


Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile 
    850                 855                 860             


<210>  3568
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP3__Homo_sapiens__NP_005012

<400>  3568

Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
1               5                   10                  15      


Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
            20                  25                  30          


Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
        35                  40                  45              


Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
    50                  55                  60                  


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
65                  70                  75                  80  


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                85                  90                  95      


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
            100                 105                 110         


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
        115                 120                 125             


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
    130                 135                 140                 


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
145                 150                 155                 160 


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                165                 170                 175     


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
            180                 185                 190         


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
        195                 200                 205             


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    210                 215                 220                 


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
225                 230                 235                 240 


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                245                 250                 255     


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
            260                 265                 270         


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
        275                 280                 285             


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
    290                 295                 300                 


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
305                 310                 315                 320 


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                325                 330                 335     


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
            340                 345                 350         


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
        355                 360                 365             


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
    370                 375                 380                 


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
385                 390                 395                 400 


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                405                 410                 415     


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
            420                 425                 430         


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
        435                 440                 445             


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
    450                 455                 460                 


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
465                 470                 475                 480 


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                485                 490                 495     


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
            500                 505                 510         


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
        515                 520                 525             


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
    530                 535                 540                 


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
545                 550                 555                 560 


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                565                 570                 575     


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
            580                 585                 590         


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
        595                 600                 605             


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
    610                 615                 620                 


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
625                 630                 635                 640 


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                645                 650                 655     


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
            660                 665                 670         


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
        675                 680                 685             


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
    690                 695                 700                 


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
705                 710                 715                 720 


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                725                 730                 735     


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
            740                 745                 750         


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
        755                 760                 765             


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
    770                 775                 780                 


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
785                 790                 795                 800 


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                805                 810                 815     


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
            820                 825                 830         


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
        835                 840                 845             


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
    850                 855                 860                 


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
865                 870                 875 


<210>  3569
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP5__Homo_sapiens__XP_005249317

<400>  3569

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Leu Gln Pro Asp Gln Gln Lys Val Leu Leu 
            20                  25                  30          


Val Ser Phe Asp Gly Phe Arg Trp Asp Tyr Leu Tyr Lys Val Pro Thr 
        35                  40                  45              


Pro His Phe His Tyr Ile Met Lys Tyr Gly Val His Val Lys Gln Val 
    50                  55                  60                  


Thr Asn Val Phe Ile Thr Lys Thr Tyr Pro Asn His Tyr Thr Leu Val 
65                  70                  75                  80  


Thr Gly Leu Phe Ala Glu Asn His Gly Ile Val Ala Asn Asp Met Phe 
                85                  90                  95      


Asp Pro Ile Arg Asn Lys Ser Phe Ser Leu Asp His Met Asn Ile Tyr 
            100                 105                 110         


Asp Ser Lys Phe Trp Glu Glu Ala Thr Pro Ile Trp Ile Thr Asn Gln 
        115                 120                 125             


Arg Ala Gly His Thr Ser Gly Ala Ala Met Trp Pro Gly Thr Asp Val 
    130                 135                 140                 


Lys Ile His Lys Arg Phe Pro Thr His Tyr Met Pro Tyr Asn Glu Ser 
145                 150                 155                 160 


Val Ser Phe Glu Asp Arg Val Ala Lys Ile Ile Glu Trp Phe Thr Ser 
                165                 170                 175     


Lys Glu Pro Ile Asn Leu Gly Leu Leu Tyr Trp Glu Asp Pro Asp Asp 
            180                 185                 190         


Met Gly His His Leu Gly Pro Asp Ser Pro Leu Met Gly Pro Val Ile 
        195                 200                 205             


Ser Asp Ile Asp Lys Lys Leu Gly Tyr Leu Ile Gln Met Leu Lys Lys 
    210                 215                 220                 


Ala Lys Leu Trp Asn Thr Leu Asn Leu Ile Ile Thr Ser Asp His Gly 
225                 230                 235                 240 


Met Thr Gln Cys Ser Glu Glu Arg Leu Ile Glu Leu Asp Gln Tyr Leu 
                245                 250                 255     


Asp Lys Asp His Tyr Thr Leu Ile Asp Gln Ser Pro Val Ala Ala Ile 
            260                 265                 270         


Leu Pro Lys Glu Gly Lys Phe Asp Glu Val Tyr Glu Ala Leu Thr His 
        275                 280                 285             


Ala His Pro Asn Leu Thr Val Tyr Lys Lys Glu Asp Val Pro Glu Arg 
    290                 295                 300                 


Trp His Tyr Lys Tyr Asn Ser Arg Ile Gln Pro Ile Ile Ala Val Ala 
305                 310                 315                 320 


Asp Glu Gly Trp His Ile Leu Gln Asn Lys Ser Asp Asp Phe Leu Leu 
                325                 330                 335     


Gly Asn His Gly Tyr Asp Asn Ala Leu Ala Asp Met His Pro Ile Phe 
            340                 345                 350         


Leu Ala His Gly Pro Ala Phe Arg Lys Asn Phe Ser Lys Glu Ala Met 
        355                 360                 365             


Asn Ser Thr Asp Leu Tyr Pro Leu Leu Cys His Leu Leu Asn Ile Thr 
    370                 375                 380                 


Ala Met Pro His Asn Gly Ser Phe Trp Asn Val Gln Asp Leu Leu Asn 
385                 390                 395                 400 


Ser Ala Met Pro Arg Val Val Pro Tyr Thr Gln Ser Thr Ile Leu Leu 
                405                 410                 415     


Pro Gly Ser Val Lys Pro Ala Glu Tyr Asp Gln Glu Gly Ser Tyr Pro 
            420                 425                 430         


Tyr Phe Ile Gly Val Ser Leu Gly Ser Ile Ile Val Ile Val Phe Phe 
        435                 440                 445             


Val Ile Phe Ile Lys His Leu Ile His Ser Gln Ile Pro Ala Leu Gln 
    450                 455                 460                 


Asp Met His Ala Glu Ile Ala Gln Pro Leu Leu Gln Ala 
465                 470                 475         


<210>  3570
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP7__Homo_sapiens__NP_848638

<400>  3570

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Pro Val Gln Ser Gln Gly Ser Gln Asn Lys 
            20                  25                  30          


Leu Leu Leu Val Ser Phe Asp Gly Phe Arg Trp Asn Tyr Asp Gln Asp 
        35                  40                  45              


Val Asp Thr Pro Asn Leu Asp Ala Met Ala Arg Asp Gly Val Lys Ala 
    50                  55                  60                  


Arg Tyr Met Thr Pro Ala Phe Val Thr Met Thr Ser Pro Cys His Phe 
65                  70                  75                  80  


Thr Leu Val Thr Gly Lys Tyr Ile Glu Asn His Gly Val Val His Asn 
                85                  90                  95      


Met Tyr Tyr Asn Thr Thr Ser Lys Val Lys Leu Pro Tyr His Ala Thr 
            100                 105                 110         


Leu Gly Ile Gln Arg Trp Trp Asp Asn Gly Ser Val Pro Ile Trp Ile 
        115                 120                 125             


Thr Ala Gln Arg Gln Gly Leu Arg Ala Gly Ser Phe Phe Tyr Pro Gly 
    130                 135                 140                 


Gly Asn Val Thr Tyr Gln Gly Val Ala Val Thr Arg Ser Arg Lys Glu 
145                 150                 155                 160 


Gly Ile Ala His Asn Tyr Lys Asn Glu Thr Glu Trp Arg Ala Asn Ile 
                165                 170                 175     


Asp Thr Val Met Ala Trp Phe Thr Glu Glu Asp Leu Asp Leu Val Thr 
            180                 185                 190         


Leu Tyr Phe Gly Glu Pro Asp Ser Thr Gly His Arg Tyr Gly Pro Glu 
        195                 200                 205             


Ser Pro Glu Arg Arg Glu Met Val Arg Gln Val Asp Arg Thr Val Gly 
    210                 215                 220                 


Tyr Leu Arg Glu Ser Ile Ala Arg Asn His Leu Thr Asp Arg Leu Asn 
225                 230                 235                 240 


Leu Ile Ile Thr Ser Asp His Gly Met Thr Thr Val Asp Lys Arg Ala 
                245                 250                 255     


Gly Asp Leu Val Glu Phe His Lys Phe Pro Asn Phe Thr Phe Arg Asp 
            260                 265                 270         


Ile Glu Phe Glu Leu Leu Asp Tyr Gly Pro Asn Gly Met Leu Leu Pro 
        275                 280                 285             


Lys Glu Gly Arg Leu Glu Lys Val Tyr Asp Ala Leu Lys Asp Ala His 
    290                 295                 300                 


Pro Lys Leu His Val Tyr Lys Lys Glu Ala Phe Pro Glu Ala Phe His 
305                 310                 315                 320 


Tyr Ala Asn Asn Pro Arg Val Thr Pro Leu Leu Met Tyr Ser Asp Leu 
                325                 330                 335     


Gly Tyr Val Ile His Gly Arg Ile Asn Val Gln Phe Asn Asn Gly Glu 
            340                 345                 350         


His Gly Phe Asp Asn Lys Asp Met Asp Met Lys Thr Ile Phe Arg Ala 
        355                 360                 365             


Val Gly Pro Ser Phe Arg Ala Gly Leu Glu Val Glu Pro Phe Glu Ser 
    370                 375                 380                 


Val His Val Tyr Glu Leu Met Cys Arg Leu Leu Gly Ile Val Pro Glu 
385                 390                 395                 400 


Ala Asn Asp Gly His Leu Ala Thr Leu Leu Pro Met Leu His Thr Glu 
                405                 410                 415     


Ser Ala Leu Pro Pro Asp Gly Arg Pro Thr Leu Leu Pro Lys Gly Arg 
            420                 425                 430         


Ser Ala Leu Pro Pro Ser Ser Arg Pro Leu Leu Val Met Gly Leu Leu 
        435                 440                 445             


Gly Thr Val Ile Leu Leu Ser Glu Val Ala 
    450                 455             


<210>  3571
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENTHD2__Homo_sapiens__NP_653280

<400>  3571

Met Ala Ala Ala Pro Pro Leu Arg Asp Arg Leu Ser Phe Leu His Arg 
1               5                   10                  15      


Leu Pro Ile Leu Leu Lys Gly Thr Ser Asp Asp Asp Val Pro Cys Pro 
            20                  25                  30          


Gly Tyr Leu Phe Glu Glu Ile Ala Lys Ile Ser His Glu Ser Pro Gly 
        35                  40                  45              


Ser Ser Gln Cys Leu Leu Glu Tyr Leu Leu Ser Arg Leu His Ser Ser 
    50                  55                  60                  


Ser Gly His Gly Lys Leu Lys Val Leu Lys Ile Leu Leu Tyr Leu Cys 
65                  70                  75                  80  


Ser His Gly Ser Ser Phe Phe Leu Leu Ile Leu Lys Arg Asn Ser Ala 
                85                  90                  95      


Phe Ile Gln Glu Ala Ala Ala Phe Ala Gly Pro Pro Asp Pro Leu His 
            100                 105                 110         


Gly Asn Ser Leu Tyr Gln Lys Val Arg Ala Ala Ala Gln Asp Leu Gly 
        115                 120                 125             


Ser Thr Leu Phe Ser Asp Thr Val Leu Pro Leu Ala Pro Ser Gln Pro 
    130                 135                 140                 


Leu Gly Thr Pro Pro Ala Thr Gly Met Gly Ser Gln Ala Arg Pro His 
145                 150                 155                 160 


Ser Thr Leu Gln Gly Phe Gly Tyr Ser Lys Glu His Gly Arg Thr Ala 
                165                 170                 175     


Val Arg His Gln Pro Gly Gln Ala Gly Gly Gly Trp Asp Glu Leu Asp 
            180                 185                 190         


Ser Gly Pro Ser Ser Gln Asn Ser Ser Gln Asn Ser Asp Leu Ser Arg 
        195                 200                 205             


Val Ser Asp Ser Gly Ser His Ser Gly Ser Asp Ser His Ser Gly Ala 
    210                 215                 220                 


Ser Arg Glu Pro Gly Asp Leu Ala Glu Arg Val Glu Val Val Ala Leu 
225                 230                 235                 240 


Ser Asp Cys Gln Gln Glu Leu Ser Leu Val Arg Thr Val Thr Arg Gly 
                245                 250                 255     


Pro Arg Ala Phe Leu Ser Arg Glu Glu Ala Gln His Phe Ile Lys Ala 
            260                 265                 270         


Cys Gly Leu Leu Asn Cys Glu Ala Val Leu Gln Leu Leu Thr Cys His 
        275                 280                 285             


Leu Arg Gly Thr Ser Glu Cys Thr Gln Leu Arg Ala Leu Cys Ala Ile 
    290                 295                 300                 


Ala Ser Leu Gly Ser Ser Asp Leu Leu Pro Gln Glu His Ile Leu Leu 
305                 310                 315                 320 


Arg Thr Arg Pro Trp Leu Gln Glu Leu Ser Met Gly Ser Pro Gly Pro 
                325                 330                 335     


Val Thr Asn Lys Ala Thr Lys Ile Leu Arg His Phe Glu Ala Ser Cys 
            340                 345                 350         


Gly Gln Leu Ser Pro Ala Arg Gly Thr Ser Ala Glu Pro Gly Pro Thr 
        355                 360                 365             


Ala Ala Leu Pro Gly Pro Ser Asp Leu Leu Thr Asp Ala Val Pro Leu 
    370                 375                 380                 


Pro Gly Ser Gln Val Phe Leu Gln Pro Leu Ser Ser Thr Pro Val Ser 
385                 390                 395                 400 


Ser Arg Ser Pro Ala Pro Ser Ser Gly Met Pro Ser Ser Pro Val Pro 
                405                 410                 415     


Thr Pro Pro Pro Asp Ala Ser Pro Ile Pro Ala Pro Gly Asp Pro Ser 
            420                 425                 430         


Glu Ala Glu Ala Arg Leu Ala Glu Ser Arg Arg Trp Arg Pro Glu Arg 
        435                 440                 445             


Ile Pro Gly Gly Thr Asp Ser Pro Lys Arg Gly Pro Ser Ser Cys Ala 
    450                 455                 460                 


Trp Ser Arg Asp Ser Leu Phe Ala Gly Met Glu Leu Val Ala Cys Pro 
465                 470                 475                 480 


Arg Leu Val Gly Ala Gly Ala Ala Ala Gly Glu Ser Cys Pro Asp Ala 
                485                 490                 495     


Pro Arg Ala Pro Gln Thr Ser Ser Gln Arg Thr Ala Ala Lys Glu Pro 
            500                 505                 510         


Pro Gly Ser Glu Pro Ser Ala Phe Ala Phe Leu Asn Ala 
        515                 520                 525 


<210>  3572
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENTPD1__Homo_sapiens__NP_001091645

<400>  3572

Met Lys Gly Thr Lys Asp Leu Thr Ser Gln Gln Lys Glu Ser Asn Val 
1               5                   10                  15      


Lys Thr Phe Cys Ser Lys Asn Ile Leu Ala Ile Leu Gly Phe Ser Ser 
            20                  25                  30          


Ile Ile Ala Val Ile Ala Leu Leu Ala Val Gly Leu Thr Gln Asn Lys 
        35                  40                  45              


Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser 
    50                  55                  60                  


Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn 
65                  70                  75                  80  


Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro 
                85                  90                  95      


Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu 
            100                 105                 110         


Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His 
        115                 120                 125             


Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu 
    130                 135                 140                 


Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu 
145                 150                 155                 160 


Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile 
                165                 170                 175     


Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu 
            180                 185                 190         


Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr 
        195                 200                 205             


Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala 
    210                 215                 220                 


Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro 
225                 230                 235                 240 


Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr 
                245                 250                 255     


Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys 
            260                 265                 270         


Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro 
        275                 280                 285             


Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr 
    290                 295                 300                 


Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln 
305                 310                 315                 320 


Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile 
                325                 330                 335     


Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe 
            340                 345                 350         


Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser 
        355                 360                 365             


Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val 
    370                 375                 380                 


Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro 
385                 390                 395                 400 


Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu 
                405                 410                 415     


Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln 
            420                 425                 430         


Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly 
        435                 440                 445             


Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn 
    450                 455                 460                 


Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser 
465                 470                 475                 480 


His Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe 
                485                 490                 495     


Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe 
            500                 505                 510         


Trp Lys Asp Met Val 
        515         


<210>  3573
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENTPD2__Homo_sapiens__NP_001237

<400>  3573

Met Ala Gly Lys Val Arg Ser Leu Leu Pro Pro Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Gly Leu Ala Gly Leu Leu Leu Leu Cys Val Pro Thr Arg Asp Val 
            20                  25                  30          


Arg Glu Pro Pro Ala Leu Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser 
        35                  40                  45              


Ser His Thr Ser Met Phe Ile Tyr Lys Trp Pro Ala Asp Lys Glu Asn 
    50                  55                  60                  


Asp Thr Gly Ile Val Gly Gln His Ser Ser Cys Asp Val Pro Gly Gly 
65                  70                  75                  80  


Gly Ile Ser Ser Tyr Ala Asp Asn Pro Ser Gly Ala Ser Gln Ser Leu 
                85                  90                  95      


Val Gly Cys Leu Glu Gln Ala Leu Gln Asp Val Pro Lys Glu Arg His 
            100                 105                 110         


Ala Gly Thr Pro Leu Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu 
        115                 120                 125             


Asn Leu Thr Asn Pro Glu Ala Ser Thr Ser Val Leu Met Ala Val Thr 
    130                 135                 140                 


His Thr Leu Thr Gln Tyr Pro Phe Asp Phe Arg Gly Ala Arg Ile Leu 
145                 150                 155                 160 


Ser Gly Gln Glu Glu Gly Val Phe Gly Trp Val Thr Ala Asn Tyr Leu 
                165                 170                 175     


Leu Glu Asn Phe Ile Lys Tyr Gly Trp Val Gly Arg Trp Phe Arg Pro 
            180                 185                 190         


Arg Lys Gly Thr Leu Gly Ala Met Asp Leu Gly Gly Ala Ser Thr Gln 
        195                 200                 205             


Ile Thr Phe Glu Thr Thr Ser Pro Ala Glu Asp Arg Ala Ser Glu Val 
    210                 215                 220                 


Gln Leu His Leu Tyr Gly Gln His Tyr Arg Val Tyr Thr His Ser Phe 
225                 230                 235                 240 


Leu Cys Tyr Gly Arg Asp Gln Val Leu Gln Arg Leu Leu Ala Ser Ala 
                245                 250                 255     


Leu Gln Thr His Gly Phe His Pro Cys Trp Pro Arg Gly Phe Ser Thr 
            260                 265                 270         


Gln Val Leu Leu Gly Asp Val Tyr Gln Ser Pro Cys Thr Met Ala Gln 
        275                 280                 285             


Arg Pro Gln Asn Phe Asn Ser Ser Ala Arg Val Ser Leu Ser Gly Ser 
    290                 295                 300                 


Ser Asp Pro His Leu Cys Arg Asp Leu Val Ser Gly Leu Phe Ser Phe 
305                 310                 315                 320 


Ser Ser Cys Pro Phe Ser Arg Cys Ser Phe Asn Gly Val Phe Gln Pro 
                325                 330                 335     


Pro Val Ala Gly Asn Phe Val Ala Phe Ser Ala Phe Phe Tyr Thr Val 
            340                 345                 350         


Asp Phe Leu Arg Thr Ser Met Gly Leu Pro Val Ala Thr Leu Gln Gln 
        355                 360                 365             


Leu Glu Ala Ala Ala Val Asn Val Cys Asn Gln Thr Trp Ala Gln Gln 
    370                 375                 380                 


Leu Leu Ser Arg Gly Tyr Gly Phe Asp Glu Arg Ala Phe Gly Gly Val 
385                 390                 395                 400 


Ile Phe Gln Lys Lys Ala Ala Asp Thr Ala Val Gly Trp Ala Leu Gly 
                405                 410                 415     


Tyr Met Leu Asn Leu Thr Asn Leu Ile Pro Ala Asp Pro Pro Gly Leu 
            420                 425                 430         


Arg Lys Gly Thr Asp Phe Ser Ser Trp Val Val Leu Leu Leu Leu Phe 
        435                 440                 445             


Ala Ser Ala Leu Leu Ala Ala Leu Val Leu Leu Leu Arg Gln Val His 
    450                 455                 460                 


Ser Ala Lys Leu Pro Ser Thr Ile 
465                 470         


<210>  3574
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENTPD4__Homo_sapiens__NP_001122402

<400>  3574

Met Gly Arg Ile Gly Ile Ser Cys Leu Phe Pro Ala Ser Trp His Phe 
1               5                   10                  15      


Ser Ile Ser Pro Val Gly Cys Pro Arg Ile Leu Asn Thr Asn Leu Arg 
            20                  25                  30          


Gln Ile Met Val Ile Ser Val Leu Ala Ala Ala Val Ser Leu Leu Tyr 
        35                  40                  45              


Phe Ser Val Val Ile Ile Arg Asn Lys Tyr Gly Arg Leu Thr Arg Asp 
    50                  55                  60                  


Lys Lys Phe Gln Arg Tyr Leu Ala Arg Val Thr Asp Ile Glu Ala Thr 
65                  70                  75                  80  


Asp Thr Asn Asn Pro Asn Val Asn Tyr Gly Ile Val Val Asp Cys Gly 
                85                  90                  95      


Ser Ser Gly Ser Arg Val Phe Val Tyr Cys Trp Pro Arg His Asn Gly 
            100                 105                 110         


Asn Pro His Asp Leu Leu Asp Ile Arg Gln Met Arg Asp Lys Asn Arg 
        115                 120                 125             


Lys Pro Val Val Met Lys Ile Lys Pro Gly Ile Ser Glu Phe Ala Thr 
    130                 135                 140                 


Ser Pro Glu Lys Val Ser Asp Tyr Ile Ser Pro Leu Leu Asn Phe Ala 
145                 150                 155                 160 


Ala Glu His Val Pro Arg Ala Lys His Lys Glu Thr Pro Leu Tyr Ile 
                165                 170                 175     


Leu Cys Thr Ala Gly Met Arg Ile Leu Pro Glu Ser Gln Gln Lys Ala 
            180                 185                 190         


Ile Leu Glu Asp Leu Leu Thr Asp Ile Pro Val His Phe Asp Phe Leu 
        195                 200                 205             


Phe Ser Asp Ser His Ala Glu Val Ile Ser Gly Lys Gln Glu Gly Val 
    210                 215                 220                 


Tyr Ala Trp Ile Gly Ile Asn Phe Val Leu Gly Arg Phe Glu His Ile 
225                 230                 235                 240 


Glu Asp Asp Asp Glu Ala Val Val Glu Val Asn Ile Pro Gly Ser Glu 
                245                 250                 255     


Ser Ser Glu Ala Ile Val Arg Lys Arg Thr Ala Gly Ile Leu Asp Met 
            260                 265                 270         


Gly Gly Val Ser Thr Gln Ile Ala Tyr Glu Val Pro Lys Thr Glu Glu 
        275                 280                 285             


Val Ala Lys Asn Leu Leu Ala Glu Phe Asn Leu Gly Cys Asp Val His 
    290                 295                 300                 


Gln Thr Glu His Val Tyr Arg Val Tyr Val Ala Thr Phe Leu Gly Phe 
305                 310                 315                 320 


Gly Gly Asn Ala Ala Arg Gln Arg Tyr Glu Asp Arg Ile Phe Ala Asn 
                325                 330                 335     


Thr Ile Gln Lys Asn Arg Leu Leu Gly Lys Gln Thr Gly Leu Thr Pro 
            340                 345                 350         


Asp Met Pro Tyr Leu Asp Pro Cys Leu Pro Leu Asp Ile Lys Asp Glu 
        355                 360                 365             


Ile Gln Gln Asn Gly Gln Thr Ile Tyr Leu Arg Gly Thr Gly Asp Phe 
    370                 375                 380                 


Asp Leu Cys Arg Glu Thr Ile Gln Pro Phe Met Asn Lys Thr Asn Glu 
385                 390                 395                 400 


Thr Gln Thr Ser Leu Asn Gly Val Tyr Gln Pro Pro Ile His Phe Gln 
                405                 410                 415     


Asn Ser Glu Phe Tyr Gly Phe Ser Glu Phe Tyr Tyr Cys Thr Glu Asp 
            420                 425                 430         


Val Leu Arg Met Gly Gly Asp Tyr Asn Ala Ala Lys Phe Thr Lys Ala 
        435                 440                 445             


Ala Lys Asp Tyr Cys Ala Thr Lys Trp Ser Ile Leu Arg Glu Arg Phe 
    450                 455                 460                 


Asp Arg Gly Leu Tyr Ala Ser His Ala Asp Leu His Arg Leu Lys Tyr 
465                 470                 475                 480 


Gln Cys Phe Lys Ser Ala Trp Met Phe Glu Val Phe His Arg Gly Phe 
                485                 490                 495     


Ser Phe Pro Val Asn Tyr Lys Ser Leu Lys Thr Ala Leu Gln Val Tyr 
            500                 505                 510         


Asp Lys Glu Val Gln Trp Thr Leu Gly Ala Ile Leu Tyr Arg Thr Arg 
        515                 520                 525             


Phe Leu Pro Leu Arg Asp Ile Gln Gln Glu Ala Phe Arg Ala Ser His 
    530                 535                 540                 


Thr His Trp Arg Gly Val Ser Phe Val Tyr Asn His Tyr Leu Phe Ser 
545                 550                 555                 560 


Gly Cys Phe Leu Val Val Leu Leu Ala Ile Leu Leu Tyr Leu Leu Arg 
                565                 570                 575     


Leu Arg Arg Ile His Arg Arg Thr Pro Arg Ser Ser Ser Ala Ala Ala 
            580                 585                 590         


Leu Trp Met Glu Glu Gly Leu Pro Ala Gln Asn Ala Pro Gly Thr Leu 
        595                 600                 605             


<210>  3575
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENTPD5__Homo_sapiens__XP_006720387

<400>  3575

Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys 
1               5                   10                  15      


Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly 
            20                  25                  30          


Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu 
        35                  40                  45              


Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val 
    50                  55                  60                  


Tyr Thr Phe Val Gln Lys Met Pro Gly Gln Leu Pro Ile Leu Glu Gly 
65                  70                  75                  80  


Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val Asp Gln 
                85                  90                  95      


Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val Ala Lys 
            100                 105                 110         


Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val Leu Lys 
        115                 120                 125             


Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys Ala Leu 
    130                 135                 140                 


Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu Val Pro 
145                 150                 155                 160 


Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile Leu Ala 
                165                 170                 175     


Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His Arg Gln 
            180                 185                 190         


Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr 
        195                 200                 205             


Phe Leu Pro Gln Phe Glu Lys Thr Leu Glu Gln Thr Pro Arg Gly Tyr 
    210                 215                 220                 


Leu Thr Ser Phe Glu Met Phe Asn Ser Thr Tyr Lys Leu Tyr Thr His 
225                 230                 235                 240 


Ser Tyr Leu Gly Phe Gly Leu Lys Ala Ala Arg Leu Ala Thr Leu Gly 
                245                 250                 255     


Ala Leu Glu Thr Glu Gly Thr Asp Gly His Thr Phe Arg Ser Ala Cys 
            260                 265                 270         


Leu Pro Arg Trp Leu Glu Ala Glu Trp Ile Phe Gly Gly Val Lys Tyr 
        275                 280                 285             


Gln Tyr Gly Gly Asn Gln Glu Gly Glu Val Gly Phe Glu Pro Cys Tyr 
    290                 295                 300                 


Ala Glu Val Leu Arg Val Val Arg Gly Lys Leu His Gln Pro Glu Glu 
305                 310                 315                 320 


Val Gln Arg Gly Ser Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp Arg Ala 
                325                 330                 335     


Val Asp Thr Asp Met Ile Asp Tyr Glu Lys Gly Gly Ile Leu Lys Val 
            340                 345                 350         


Glu Asp Phe Glu Arg Lys Ala Arg Glu Val Cys Asp Asn Leu Glu Asn 
        355                 360                 365             


Phe Thr Ser Gly Ser Pro Phe Leu Cys Met Asp Leu Ser Tyr Ile Thr 
    370                 375                 380                 


Ala Leu Leu Lys Asp Gly Phe Gly Phe Ala Asp Ser Thr Val Leu Gln 
385                 390                 395                 400 


Leu Thr Lys Lys Val Asn Asn Ile Glu Thr Gly Trp Ala Leu Gly Ala 
                405                 410                 415     


Thr Phe His Leu Leu Gln Ser Leu Gly Ile Ser His 
            420                 425             


<210>  3576
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENTPD6__Homo_sapiens__NP_001107561

<400>  3576

Met Gln Pro Gln His Gly Pro Trp Gln Thr Arg Met Arg Lys Ile Ser 
1               5                   10                  15      


Asn His Gly Ser Leu Arg Val Ala Lys Val Ala Tyr Pro Leu Gly Leu 
            20                  25                  30          


Cys Val Gly Val Phe Ile Tyr Val Ala Tyr Ile Lys Trp His Arg Ala 
        35                  40                  45              


Thr Ala Thr Gln Ala Phe Phe Ser Ile Thr Arg Ala Ala Pro Gly Ala 
    50                  55                  60                  


Arg Trp Gly Gln Gln Ala His Ser Pro Leu Gly Thr Ala Ala Asp Gly 
65                  70                  75                  80  


His Glu Val Phe Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr 
                85                  90                  95      


Arg Val His Val Phe Gln Phe Thr Arg Pro Pro Arg Glu Thr Pro Thr 
            100                 105                 110         


Leu Thr His Glu Thr Phe Lys Ala Leu Lys Pro Gly Leu Ser Ala Tyr 
        115                 120                 125             


Ala Asp Asp Val Glu Lys Ser Ala Gln Gly Ile Arg Glu Leu Leu Asp 
    130                 135                 140                 


Val Ala Lys Gln Asp Ile Pro Phe Asp Phe Trp Lys Ala Thr Pro Leu 
145                 150                 155                 160 


Val Leu Lys Ala Thr Ala Gly Leu Arg Leu Leu Pro Gly Glu Lys Ala 
                165                 170                 175     


Gln Lys Leu Leu Gln Lys Val Lys Glu Val Phe Lys Ala Ser Pro Phe 
            180                 185                 190         


Leu Val Gly Asp Asp Cys Val Ser Ile Met Asn Gly Thr Asp Glu Gly 
        195                 200                 205             


Val Ser Ala Trp Ile Thr Ile Asn Phe Leu Thr Gly Ser Leu Lys Thr 
    210                 215                 220                 


Pro Gly Gly Ser Ser Val Gly Met Leu Asp Leu Gly Gly Gly Ser Thr 
225                 230                 235                 240 


Gln Ile Ala Phe Leu Pro Arg Val Glu Gly Thr Leu Gln Ala Ser Pro 
                245                 250                 255     


Pro Gly Tyr Leu Thr Ala Leu Arg Met Phe Asn Arg Thr Tyr Lys Leu 
            260                 265                 270         


Tyr Ser Tyr Ser Tyr Leu Gly Leu Gly Leu Met Ser Ala Arg Leu Ala 
        275                 280                 285             


Ile Leu Gly Gly Val Glu Gly Gln Pro Ala Lys Asp Gly Lys Glu Leu 
    290                 295                 300                 


Val Ser Pro Cys Leu Ser Pro Ser Phe Lys Gly Glu Trp Glu His Ala 
305                 310                 315                 320 


Glu Val Thr Tyr Arg Val Ser Gly Gln Lys Ala Ala Ala Ser Leu His 
                325                 330                 335     


Glu Leu Cys Ala Ala Arg Val Ser Glu Val Leu Gln Asn Arg Val His 
            340                 345                 350         


Arg Thr Glu Glu Val Lys His Val Asp Phe Tyr Ala Phe Ser Tyr Tyr 
        355                 360                 365             


Tyr Asp Leu Ala Ala Gly Val Gly Leu Ile Asp Ala Glu Lys Gly Gly 
    370                 375                 380                 


Ser Leu Val Val Gly Asp Phe Glu Ile Ala Ala Lys Tyr Val Cys Arg 
385                 390                 395                 400 


Thr Leu Glu Thr Gln Pro Gln Ser Ser Pro Phe Ser Cys Met Asp Leu 
                405                 410                 415     


Thr Tyr Val Ser Leu Leu Leu Gln Glu Phe Gly Phe Pro Arg Ser Lys 
            420                 425                 430         


Val Leu Lys Leu Thr Arg Lys Ile Asp Asn Val Glu Thr Ser Trp Ala 
        435                 440                 445             


Leu Gly Ala Ile Phe His Tyr Ile Asp Ser Leu Asn Arg Gln Lys Ser 
    450                 455                 460                 


Pro Ala Ser 
465         


<210>  3577
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENTPD7__Homo_sapiens__NP_065087

<400>  3577

Met Ala Arg Ile Ser Phe Ser Tyr Leu Cys Pro Ala Ser Trp Tyr Phe 
1               5                   10                  15      


Thr Val Pro Thr Val Ser Pro Phe Leu Arg Gln Arg Val Ala Phe Leu 
            20                  25                  30          


Gly Leu Phe Phe Ile Ser Cys Leu Leu Leu Leu Met Leu Ile Ile Asp 
        35                  40                  45              


Phe Arg His Trp Ser Ala Ser Leu Pro Arg Asp Arg Gln Tyr Glu Arg 
    50                  55                  60                  


Tyr Leu Ala Arg Val Gly Glu Leu Glu Ala Thr Asp Thr Glu Asp Pro 
65                  70                  75                  80  


Asn Leu Asn Tyr Gly Leu Val Val Asp Cys Gly Ser Ser Gly Ser Arg 
                85                  90                  95      


Ile Phe Val Tyr Phe Trp Pro Arg His Asn Gly Asn Pro His Asp Leu 
            100                 105                 110         


Leu Asp Ile Lys Gln Met Arg Asp Arg Asn Ser Gln Pro Val Val Lys 
        115                 120                 125             


Lys Ile Lys Pro Gly Ile Ser Ala Met Ala Asp Thr Pro Glu His Ala 
    130                 135                 140                 


Ser Asp Tyr Leu Arg Pro Leu Leu Ser Phe Ala Ala Ala His Val Pro 
145                 150                 155                 160 


Val Lys Lys His Lys Glu Thr Pro Leu Tyr Ile Leu Cys Thr Ala Gly 
                165                 170                 175     


Met Arg Leu Leu Pro Glu Arg Lys Gln Leu Ala Ile Leu Ala Asp Leu 
            180                 185                 190         


Val Lys Asp Leu Pro Leu Glu Phe Asp Phe Leu Phe Ser Gln Ser Gln 
        195                 200                 205             


Ala Glu Val Ile Ser Gly Lys Gln Glu Gly Val Tyr Ala Trp Ile Gly 
    210                 215                 220                 


Ile Asn Phe Val Leu Gly Arg Phe Asp His Glu Asp Glu Ser Asp Ala 
225                 230                 235                 240 


Glu Ala Thr Gln Glu Leu Ala Ala Gly Arg Arg Arg Thr Val Gly Ile 
                245                 250                 255     


Leu Asp Met Gly Gly Ala Ser Leu Gln Ile Ala Tyr Glu Val Pro Thr 
            260                 265                 270         


Ser Thr Ser Val Leu Pro Ala Lys Gln Glu Glu Ala Ala Lys Ile Leu 
        275                 280                 285             


Leu Ala Glu Phe Asn Leu Gly Cys Asp Val Gln His Thr Glu His Val 
    290                 295                 300                 


Tyr Arg Val Tyr Val Thr Thr Phe Leu Gly Phe Gly Gly Asn Phe Ala 
305                 310                 315                 320 


Arg Gln Arg Tyr Glu Asp Leu Val Leu Asn Glu Thr Leu Asn Lys Asn 
                325                 330                 335     


Arg Leu Leu Gly Gln Lys Thr Gly Leu Ser Pro Asp Asn Pro Phe Leu 
            340                 345                 350         


Asp Pro Cys Leu Pro Val Gly Leu Thr Asp Val Val Glu Arg Asn Ser 
        355                 360                 365             


Gln Val Leu His Val Arg Gly Arg Gly Asp Trp Val Ser Cys Gly Ala 
    370                 375                 380                 


Met Leu Ser Pro Leu Leu Ala Arg Ser Asn Thr Ser Gln Ala Ser Leu 
385                 390                 395                 400 


Asn Gly Ile Tyr Gln Ser Pro Ile Asp Phe Asn Asn Ser Glu Phe Tyr 
                405                 410                 415     


Gly Phe Ser Glu Phe Phe Tyr Cys Thr Glu Asp Val Leu Arg Ile Gly 
            420                 425                 430         


Gly Arg Tyr His Gly Pro Thr Phe Ala Lys Ala Ala Gln Asp Tyr Cys 
        435                 440                 445             


Gly Met Ala Trp Ser Val Leu Thr Gln Arg Phe Lys Asn Gly Leu Phe 
    450                 455                 460                 


Ser Ser His Ala Asp Glu His Arg Leu Lys Tyr Gln Cys Phe Lys Ser 
465                 470                 475                 480 


Ala Trp Met Tyr Gln Val Leu His Glu Gly Phe His Phe Pro Tyr Asp 
                485                 490                 495     


Tyr Pro Asn Leu Arg Thr Ala Gln Leu Val Tyr Asp Arg Glu Val Gln 
            500                 505                 510         


Trp Thr Leu Gly Ala Ile Leu Tyr Lys Thr Arg Phe Leu Pro Leu Arg 
        515                 520                 525             


Asp Leu Arg Gln Glu Gly Val Arg Gln Ala His Gly Ser Trp Phe Arg 
    530                 535                 540                 


Leu Ser Phe Val Tyr Asn His Tyr Leu Phe Phe Ala Cys Ile Leu Val 
545                 550                 555                 560 


Val Leu Leu Ala Ile Phe Leu Tyr Leu Leu Arg Leu Arg Arg Ile His 
                565                 570                 575     


His Arg Gln Thr Arg Ala Ser Ala Pro Leu Asp Leu Leu Trp Leu Glu 
            580                 585                 590         


Glu Val Val Pro Met Met Gly Val Gln Val Gly Pro 
        595                 600                 


<210>  3578
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EOGT__Homo_sapiens__NP_001265618

<400>  3578

Met Leu Met Leu Phe Val Phe Gly Val Leu Leu His Glu Val Ser Leu 
1               5                   10                  15      


Ser Gly Gln Asn Glu Ala Pro Pro Asn Thr His Ser Ile Pro Gly Glu 
            20                  25                  30          


Pro Leu Tyr Asn Tyr Ala Ser Ile Arg Leu Pro Glu Glu His Ile Pro 
        35                  40                  45              


Phe Phe Leu His Asn Asn Arg His Ile Ala Thr Val Cys Arg Lys Asp 
    50                  55                  60                  


Ser Leu Cys Pro Tyr Lys Lys His Leu Glu Lys Leu Lys Tyr Cys Trp 
65                  70                  75                  80  


Gly Tyr Glu Lys Ser Cys Lys Pro Glu Phe Arg Phe Gly Tyr Pro Val 
                85                  90                  95      


Cys Ser Tyr Val Asp Met Gly Trp Thr Asp Thr Leu Glu Ser Ala Glu 
            100                 105                 110         


Asp Ile Phe Trp Lys Gln Ala Asp Phe Gly Tyr Ala Arg Glu Arg Leu 
        115                 120                 125             


Glu Glu Met His Val Leu Cys Gln Pro Lys Glu Thr Ser Asp Ser Ser 
    130                 135                 140                 


Leu Val Cys Ser Arg Tyr Leu Gln Tyr Cys Arg Ala Thr Asn Leu Tyr 
145                 150                 155                 160 


Leu Asp Leu Arg Asn Ile Lys Arg Asn His Asp Arg Phe Lys Glu Asp 
                165                 170                 175     


Phe Phe Gln Ser Gly Glu Ile Gly Gly His Cys Lys Leu Asp Ile Arg 
            180                 185                 190         


Thr Leu Thr Ser Glu Gly Gln Arg Lys Ser Pro Leu Gln Ser Trp Phe 
        195                 200                 205             


Ala Glu Leu Gln Ser Tyr Thr Gln Leu Asn Phe Arg Pro Ile Glu Asp 
    210                 215                 220                 


Ala Lys Cys Asp Ile Val Ile Glu Lys Pro Thr Tyr Phe Met Lys Leu 
225                 230                 235                 240 


Asp Ala Gly Val Asn Met Tyr His His Phe Cys Asp Phe Ile Asn Leu 
                245                 250                 255     


Tyr Ile Thr Gln His Val Asn Asn Ser Phe Ser Thr Asp Val Tyr Ile 
            260                 265                 270         


Val Met Trp Asp Thr Ser Ser Tyr Gly Tyr Gly Asp Leu Phe Ser Asp 
        275                 280                 285             


Thr Trp Asn Ala Phe Thr Asp Tyr Asp Val Ile His Leu Lys Thr Tyr 
    290                 295                 300                 


Asp Ser Lys Arg Val Cys Phe Lys Glu Ala Val Phe Ser Leu Leu Pro 
305                 310                 315                 320 


Arg Met Arg Tyr Gly Leu Phe Tyr Asn Thr Pro Leu Ile Ser Gly Cys 
                325                 330                 335     


Gln Asn Thr Gly Leu Phe Arg Ala Phe Ala Gln His Val Leu His Arg 
            340                 345                 350         


Leu Asn Ile Thr Gln Glu Gly Pro Lys Asp Gly Lys Ile Arg Val Thr 
        355                 360                 365             


Ile Leu Ala Arg Ser Thr Glu Tyr Arg Lys Ile Leu Asn Gln Asn Glu 
    370                 375                 380                 


Leu Val Asn Ala Leu Lys Thr Val Ser Thr Phe Glu Val Gln Ile Val 
385                 390                 395                 400 


Asp Tyr Lys Tyr Arg Glu Leu Gly Phe Leu Asp Gln Leu Arg Ile Thr 
                405                 410                 415     


His Asn Thr Asp Ile Phe Ile Gly Met His Gly Ala Gly Leu Thr His 
            420                 425                 430         


Leu Leu Phe Leu Pro Asp Trp Ala Ala Val Phe Glu Leu Tyr Asn Cys 
        435                 440                 445             


Glu Asp Glu Arg Cys Tyr Leu Asp Leu Ala Arg Leu Arg Gly Val His 
    450                 455                 460                 


Tyr Ile Thr Trp Arg Arg Gln Asn Lys Val Phe Pro Gln Asp Lys Gly 
465                 470                 475                 480 


His His Pro Thr Leu Gly Glu His Pro Lys Phe Thr Asn Tyr Ser Phe 
                485                 490                 495     


Asp Val Glu Glu Phe Met Tyr Leu Val Leu Gln Ala Ala Asp His Val 
            500                 505                 510         


Leu Gln His Pro Lys Trp Pro Phe Lys Lys Lys His Asp Glu Leu 
        515                 520                 525         


<210>  3579
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EOMES__Homo_sapiens__NP_001265111

<400>  3579

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Pro Leu Glu Ser Ala Arg Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Ala Gly His Leu Pro Ser Ala Ala Pro Ser Pro Gln Lys Leu Asp Leu 
        35                  40                  45              


Asp Lys Ala Ser Lys Lys Phe Ser Gly Ser Leu Ser Cys Glu Ala Val 
    50                  55                  60                  


Ser Gly Glu Pro Ala Ala Ala Ser Ala Gly Ala Pro Ala Ala Met Leu 
65                  70                  75                  80  


Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala Ala Val Ala 
                85                  90                  95      


Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys Gly Glu Glu 
            100                 105                 110         


Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala Pro Cys 
145                 150                 155                 160 


Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His Gly Pro Val 
                165                 170                 175     


Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met Leu Pro 
            180                 185                 190         


Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg Ala Gln Phe 
        195                 200                 205             


Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala Pro Leu Tyr 
225                 230                 235                 240 


Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly Gly Leu Gly 
                245                 250                 255     


Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr Leu Cys 
            260                 265                 270         


Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile 
        275                 280                 285             


Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile 
    290                 295                 300                 


Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu Val Val 
305                 310                 315                 320 


Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Thr 
                325                 330                 335     


Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr Val His 
            340                 345                 350         


Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu Ile Ser 
        355                 360                 365             


Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn Asn Asn 
    370                 375                 380                 


Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu 
385                 390                 395                 400 


His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn Glu Pro 
                405                 410                 415     


Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile Ala Val 
            420                 425                 430         


Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn 
        435                 440                 445             


Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Met Tyr Thr Ala 
    450                 455                 460                 


Ser Glu Asn Asp Arg Leu Thr Pro Ser Pro Thr Asp Ser Pro Arg Ser 
465                 470                 475                 480 


His Gln Ile Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro 
                485                 490                 495     


Glu Pro Phe Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu 
            500                 505                 510         


Arg Thr Val Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu 
        515                 520                 525             


Glu Val Ala Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln 
    530                 535                 540                 


Pro Gly Thr Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr 
545                 550                 555                 560 


Ser Ser Thr Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr 
                565                 570                 575     


Ser His Ala Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala 
            580                 585                 590         


Gly Trp Gly Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu 
        595                 600                 605             


Pro Trp Thr Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu 
    610                 615                 620                 


Ser Lys Glu Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr 
625                 630                 635                 640 


Pro Pro Ser Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr 
                645                 650                 655     


Ser Ala Cys Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu 
            660                 665                 670         


Asn Ser Pro Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser 
        675                 680                 685             


Lys Asp Thr Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr 
    690                 695                 700                 


Pro 
705 


<210>  3580
<211>  2414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP300__Homo_sapiens__NP_001420

<400>  3580

Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210>  3581
<211>  3123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EP400__Homo_sapiens__NP_056224

<400>  3581

Met His His Gly Thr Gly Pro Gln Asn Val Gln His Gln Leu Gln Arg 
1               5                   10                  15      


Ser Arg Ala Cys Pro Gly Ser Glu Gly Glu Glu Gln Pro Ala His Pro 
            20                  25                  30          


Asn Pro Pro Pro Ser Pro Ala Ala Pro Phe Ala Pro Ser Ala Ser Pro 
        35                  40                  45              


Ser Ala Pro Gln Ser Pro Ser Tyr Gln Ile Gln Gln Leu Met Asn Arg 
    50                  55                  60                  


Ser Pro Ala Thr Gly Gln Asn Val Asn Ile Thr Leu Gln Ser Val Gly 
65                  70                  75                  80  


Pro Val Val Gly Gly Asn Gln Gln Ile Thr Leu Ala Pro Leu Pro Leu 
                85                  90                  95      


Pro Ser Pro Thr Ser Pro Gly Phe Gln Phe Ser Ala Gln Pro Arg Arg 
            100                 105                 110         


Phe Glu His Gly Ser Pro Ser Tyr Ile Gln Val Thr Ser Pro Leu Ser 
        115                 120                 125             


Gln Gln Val Gln Thr Gln Ser Pro Thr Gln Pro Ser Pro Gly Pro Gly 
    130                 135                 140                 


Gln Ala Leu Gln Asn Val Arg Ala Gly Ala Pro Gly Pro Gly Leu Gly 
145                 150                 155                 160 


Leu Cys Ser Ser Ser Pro Thr Gly Gly Phe Val Asp Ala Ser Val Leu 
                165                 170                 175     


Val Arg Gln Ile Ser Leu Ser Pro Ser Ser Gly Gly His Phe Val Phe 
            180                 185                 190         


Gln Asp Gly Ser Gly Leu Thr Gln Ile Ala Gln Gly Ala Gln Val Gln 
        195                 200                 205             


Leu Gln His Pro Gly Thr Pro Ile Thr Val Arg Glu Arg Arg Pro Ser 
    210                 215                 220                 


Gln Pro His Thr Gln Ser Gly Gly Thr Ile His His Leu Gly Pro Gln 
225                 230                 235                 240 


Ser Pro Ala Ala Ala Gly Gly Ala Gly Leu Gln Pro Leu Ala Ser Pro 
                245                 250                 255     


Ser His Ile Thr Thr Ala Asn Leu Pro Pro Gln Ile Ser Ser Ile Ile 
            260                 265                 270         


Gln Gly Gln Leu Val Gln Gln Gln Gln Val Leu Gln Gly Pro Pro Leu 
        275                 280                 285             


Pro Arg Pro Leu Gly Phe Glu Arg Thr Pro Gly Val Leu Leu Pro Gly 
    290                 295                 300                 


Ala Gly Gly Ala Ala Gly Phe Gly Met Thr Ser Pro Pro Pro Pro Thr 
305                 310                 315                 320 


Ser Pro Ser Arg Thr Ala Val Pro Pro Gly Leu Ser Ser Leu Pro Leu 
                325                 330                 335     


Thr Ser Val Gly Asn Thr Gly Met Lys Lys Val Pro Lys Lys Leu Glu 
            340                 345                 350         


Glu Ile Pro Pro Ala Ser Pro Glu Met Ala Gln Met Arg Lys Gln Cys 
        355                 360                 365             


Leu Asp Tyr His Tyr Gln Glu Met Gln Ala Leu Lys Glu Val Phe Lys 
    370                 375                 380                 


Glu Tyr Leu Ile Glu Leu Phe Phe Leu Gln His Phe Gln Gly Asn Met 
385                 390                 395                 400 


Met Asp Phe Leu Ala Phe Lys Lys Lys His Tyr Ala Pro Leu Gln Ala 
                405                 410                 415     


Tyr Leu Arg Gln Asn Asp Leu Asp Ile Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Glu Glu Glu Glu Glu Lys Ser Glu Val Ile Asn Asp Glu Gln Gln Ala 
        435                 440                 445             


Leu Ala Gly Ser Leu Val Ala Gly Ala Gly Ser Thr Val Glu Thr Asp 
    450                 455                 460                 


Leu Phe Lys Arg Gln Gln Ala Met Pro Ser Thr Gly Met Ala Glu Gln 
465                 470                 475                 480 


Ser Lys Arg Pro Arg Leu Glu Val Gly His Gln Gly Val Val Phe Gln 
                485                 490                 495     


His Pro Gly Ala Asp Ala Gly Val Pro Leu Gln Gln Leu Met Pro Thr 
            500                 505                 510         


Ala Gln Gly Gly Met Pro Pro Thr Pro Gln Ala Ala Gln Leu Ala Gly 
        515                 520                 525             


Gln Arg Gln Ser Gln Gln Gln Tyr Asp Pro Ser Thr Gly Pro Pro Val 
    530                 535                 540                 


Gln Asn Ala Ala Ser Leu His Thr Pro Leu Pro Gln Leu Pro Gly Arg 
545                 550                 555                 560 


Leu Pro Pro Ala Gly Val Pro Thr Ala Ala Leu Ser Ser Ala Leu Gln 
                565                 570                 575     


Phe Ala Gln Gln Pro Gln Val Val Glu Ala Gln Thr Gln Leu Gln Ile 
            580                 585                 590         


Pro Val Lys Thr Gln Gln Pro Asn Val Pro Ile Pro Ala Pro Pro Ser 
        595                 600                 605             


Ser Gln Leu Pro Ile Pro Pro Ser Gln Pro Ala Gln Leu Ala Leu His 
    610                 615                 620                 


Val Pro Thr Pro Gly Lys Val Gln Val Gln Ala Ser Gln Leu Ser Ser 
625                 630                 635                 640 


Leu Pro Gln Met Val Ala Ser Thr Arg Leu Pro Val Asp Pro Ala Pro 
                645                 650                 655     


Pro Cys Pro Arg Pro Leu Pro Thr Ser Ser Thr Ser Ser Leu Ala Pro 
            660                 665                 670         


Val Ser Gly Ser Gly Pro Gly Pro Ser Pro Ala Arg Ser Ser Pro Val 
        675                 680                 685             


Asn Arg Pro Ser Ser Ala Thr Asn Lys Ala Leu Ser Pro Val Thr Ser 
    690                 695                 700                 


Arg Thr Pro Gly Val Val Ala Ser Ala Pro Thr Lys Pro Gln Ser Pro 
705                 710                 715                 720 


Ala Gln Asn Ala Thr Ser Ser Gln Asp Ser Ser Gln Asp Thr Leu Thr 
                725                 730                 735     


Glu Gln Ile Thr Leu Glu Asn Gln Val His Gln Arg Ile Ala Glu Leu 
            740                 745                 750         


Arg Lys Ala Gly Leu Trp Ser Gln Arg Arg Leu Pro Lys Leu Gln Glu 
        755                 760                 765             


Ala Pro Arg Pro Lys Ser His Trp Asp Tyr Leu Leu Glu Glu Met Gln 
    770                 775                 780                 


Trp Met Ala Thr Asp Phe Ala Gln Glu Arg Arg Trp Lys Val Ala Ala 
785                 790                 795                 800 


Ala Lys Lys Leu Val Arg Thr Val Val Arg His His Glu Glu Lys Gln 
                805                 810                 815     


Leu Arg Glu Glu Arg Gly Lys Lys Glu Glu Gln Ser Arg Leu Arg Arg 
            820                 825                 830         


Ile Ala Ala Ser Thr Ala Arg Glu Ile Glu Cys Phe Trp Ser Asn Ile 
        835                 840                 845             


Glu Gln Val Val Glu Ile Lys Leu Arg Val Glu Leu Glu Glu Lys Arg 
    850                 855                 860                 


Lys Lys Ala Leu Asn Leu Gln Lys Val Ser Arg Arg Gly Lys Glu Leu 
865                 870                 875                 880 


Arg Pro Lys Gly Phe Asp Ala Leu Gln Glu Ser Ser Leu Asp Ser Gly 
                885                 890                 895     


Met Ser Gly Arg Lys Arg Lys Ala Ser Ile Ser Leu Thr Asp Asp Glu 
            900                 905                 910         


Val Asp Asp Glu Glu Glu Thr Ile Glu Glu Glu Glu Ala Asn Glu Gly 
        915                 920                 925             


Val Val Asp His Gln Thr Glu Leu Ser Asn Leu Ala Lys Glu Ala Glu 
    930                 935                 940                 


Leu Pro Leu Leu Asp Leu Met Lys Leu Tyr Glu Gly Ala Phe Leu Pro 
945                 950                 955                 960 


Ser Ser Gln Trp Pro Arg Pro Lys Pro Asp Gly Glu Asp Thr Ser Gly 
                965                 970                 975     


Glu Glu Asp Ala Asp Asp Cys Pro Gly Asp Arg Glu Ser Arg Lys Asp 
            980                 985                 990         


Leu Val Leu Ile Asp Ser Leu Phe  Ile Met Asp Gln Phe  Lys Ala Ala 
        995                 1000                 1005             


Glu Arg  Met Asn Ile Gly Lys  Pro Asn Ala Lys Asp  Ile Ala Asp 
    1010                 1015                 1020             


Val Thr  Ala Val Ala Glu Ala  Ile Leu Pro Lys Gly  Ser Ala Arg 
    1025                 1030                 1035             


Val Thr  Thr Ser Val Lys Phe  Asn Ala Pro Ser Leu  Leu Tyr Gly 
    1040                 1045                 1050             


Ala Leu  Arg Asp Tyr Gln Lys  Ile Gly Leu Asp Trp  Leu Ala Lys 
    1055                 1060                 1065             


Leu Tyr  Arg Lys Asn Leu Asn  Gly Ile Leu Ala Asp  Glu Ala Gly 
    1070                 1075                 1080             


Leu Gly  Lys Thr Val Gln Ile  Ile Ala Phe Phe Ala  His Leu Ala 
    1085                 1090                 1095             


Cys Asn  Glu Gly Asn Trp Gly  Pro His Leu Val Val  Val Arg Ser 
    1100                 1105                 1110             


Cys Asn  Ile Leu Lys Trp Glu  Leu Glu Leu Lys Arg  Trp Cys Pro 
    1115                 1120                 1125             


Gly Leu  Lys Ile Leu Ser Tyr  Ile Gly Ser His Arg  Glu Leu Lys 
    1130                 1135                 1140             


Ala Lys  Arg Gln Glu Trp Ala  Glu Pro Asn Ser Phe  His Val Cys 
    1145                 1150                 1155             


Ile Thr  Ser Tyr Thr Gln Phe  Phe Arg Gly Leu Thr  Ala Phe Thr 
    1160                 1165                 1170             


Arg Val  Arg Trp Lys Cys Leu  Val Ile Asp Glu Met  Gln Arg Val 
    1175                 1180                 1185             


Lys Gly  Met Thr Glu Arg His  Trp Glu Ala Val Phe  Thr Leu Gln 
    1190                 1195                 1200             


Ser Gln  Gln Arg Leu Leu Leu  Ile Asp Ser Pro Leu  His Asn Thr 
    1205                 1210                 1215             


Phe Leu  Glu Leu Trp Thr Met  Val His Phe Leu Val  Pro Gly Ile 
    1220                 1225                 1230             


Ser Arg  Pro Tyr Leu Ser Ser  Pro Leu Arg Ala Pro  Ser Glu Glu 
    1235                 1240                 1245             


Ser Gln  Asp Tyr Tyr His Lys  Val Val Ile Arg Leu  His Arg Val 
    1250                 1255                 1260             


Thr Gln  Pro Phe Ile Leu Arg  Arg Thr Lys Arg Asp  Val Glu Lys 
    1265                 1270                 1275             


Gln Leu  Thr Lys Lys Tyr Glu  His Val Leu Lys Cys  Arg Leu Ser 
    1280                 1285                 1290             


Asn Arg  Gln Lys Ala Leu Tyr  Glu Asp Val Ile Leu  Gln Pro Gly 
    1295                 1300                 1305             


Thr Gln  Glu Ala Leu Lys Ser  Gly His Phe Val Asn  Val Leu Ser 
    1310                 1315                 1320             


Ile Leu  Val Arg Leu Gln Arg  Ile Cys Asn His Pro  Gly Leu Val 
    1325                 1330                 1335             


Glu Pro  Arg His Pro Gly Ser  Ser Tyr Val Ala Gly  Pro Leu Glu 
    1340                 1345                 1350             


Tyr Pro  Ser Ala Ser Leu Ile  Leu Lys Ala Leu Glu  Arg Asp Phe 
    1355                 1360                 1365             


Trp Lys  Glu Ala Asp Leu Ser  Met Phe Asp Leu Ile  Gly Leu Glu 
    1370                 1375                 1380             


Asn Lys  Ile Thr Arg His Glu  Ala Glu Leu Leu Ser  Lys Lys Lys 
    1385                 1390                 1395             


Ile Pro  Arg Lys Leu Met Glu  Glu Ile Ser Thr Ser  Ala Ala Pro 
    1400                 1405                 1410             


Ala Ala  Arg Pro Ala Ala Ala  Lys Leu Lys Ala Ser  Arg Leu Phe 
    1415                 1420                 1425             


Gln Pro  Val Gln Tyr Gly Gln  Lys Pro Glu Gly Arg  Thr Val Ala 
    1430                 1435                 1440             


Phe Pro  Ser Thr His Pro Pro  Arg Thr Ala Ala Pro  Thr Thr Ala 
    1445                 1450                 1455             


Ser Ala  Ala Pro Gln Gly Pro  Leu Arg Gly Arg Pro  Pro Ile Ala 
    1460                 1465                 1470             


Thr Phe  Ser Ala Asn Pro Glu  Ala Lys Ala Ala Ala  Ala Pro Phe 
    1475                 1480                 1485             


Gln Thr  Ser Gln Ala Ser Ala  Ser Ala Pro Arg His  Gln Pro Ala 
    1490                 1495                 1500             


Ser Ala  Ser Ser Thr Ala Ala  Ser Pro Ala His Pro  Ala Lys Leu 
    1505                 1510                 1515             


Arg Ala  Gln Thr Thr Ala Gln  Ala Ser Thr Pro Gly  Gln Pro Pro 
    1520                 1525                 1530             


Pro Gln  Pro Gln Ala Pro Ser  His Ala Ala Gly Gln  Ser Ala Leu 
    1535                 1540                 1545             


Pro Gln  Arg Leu Val Leu Pro  Ser Gln Ala Gln Ala  Arg Leu Pro 
    1550                 1555                 1560             


Ser Gly  Glu Val Val Lys Ile  Ala Gln Leu Ala Ser  Ile Thr Gly 
    1565                 1570                 1575             


Pro Gln  Ser Arg Val Ala Gln  Pro Glu Thr Pro Val  Thr Leu Gln 
    1580                 1585                 1590             


Phe Gln  Gly Ser Lys Phe Thr  Leu Ser His Ser Gln  Leu Arg Gln 
    1595                 1600                 1605             


Leu Thr  Ala Gly Gln Pro Leu  Gln Leu Gln Gly Ser  Val Leu Gln 
    1610                 1615                 1620             


Ile Val  Ser Ala Pro Gly Gln  Pro Tyr Leu Arg Ala  Pro Gly Pro 
    1625                 1630                 1635             


Val Val  Met Gln Thr Val Ser  Gln Ala Gly Ala Val  His Gly Ala 
    1640                 1645                 1650             


Leu Gly  Ser Lys Pro Pro Ala  Gly Gly Pro Ser Pro  Ala Pro Leu 
    1655                 1660                 1665             


Thr Pro  Gln Val Gly Val Pro  Gly Arg Val Ala Val  Asn Ala Leu 
    1670                 1675                 1680             


Ala Val  Gly Glu Pro Gly Thr  Ala Ser Lys Pro Ala  Ser Pro Ile 
    1685                 1690                 1695             


Gly Gly  Pro Thr Gln Glu Glu  Lys Thr Arg Leu Leu  Lys Glu Arg 
    1700                 1705                 1710             


Leu Asp  Gln Ile Tyr Leu Val  Asn Glu Arg Arg Cys  Ser Gln Ala 
    1715                 1720                 1725             


Pro Val  Tyr Gly Arg Asp Leu  Leu Arg Ile Cys Ala  Leu Pro Ser 
    1730                 1735                 1740             


His Gly  Arg Val Gln Trp Arg  Gly Ser Leu Asp Gly  Arg Arg Gly 
    1745                 1750                 1755             


Lys Glu  Ala Gly Pro Ala His  Ser Tyr Thr Ser Ser  Ser Glu Ser 
    1760                 1765                 1770             


Pro Ser  Glu Leu Met Leu Thr  Leu Cys Arg Cys Gly  Glu Ser Leu 
    1775                 1780                 1785             


Gln Asp  Val Ile Asp Arg Val  Ala Phe Val Ile Pro  Pro Val Val 
    1790                 1795                 1800             


Ala Ala  Pro Pro Ser Leu Arg  Val Pro Arg Pro Pro  Pro Leu Tyr 
    1805                 1810                 1815             


Ser His  Arg Met Arg Ile Leu  Arg Gln Gly Leu Arg  Glu His Ala 
    1820                 1825                 1830             


Ala Pro  Tyr Phe Gln Gln Leu  Arg Gln Thr Thr Ala  Pro Arg Leu 
    1835                 1840                 1845             


Leu Gln  Phe Pro Glu Leu Arg  Leu Val Gln Phe Asp  Ser Gly Lys 
    1850                 1855                 1860             


Leu Glu  Ala Leu Ala Ile Leu  Leu Gln Lys Leu Lys  Ser Glu Gly 
    1865                 1870                 1875             


Arg Arg  Val Leu Ile Leu Ser  Gln Met Ile Leu Met  Leu Asp Ile 
    1880                 1885                 1890             


Leu Glu  Met Phe Leu Asn Phe  His Tyr Leu Thr Tyr  Val Arg Ile 
    1895                 1900                 1905             


Asp Glu  Asn Ala Ser Ser Glu  Gln Arg Gln Glu Leu  Met Arg Ser 
    1910                 1915                 1920             


Phe Asn  Arg Asp Arg Arg Ile  Phe Cys Ala Ile Leu  Ser Thr His 
    1925                 1930                 1935             


Ser Arg  Thr Thr Gly Ile Asn  Leu Val Glu Ala Asp  Thr Val Val 
    1940                 1945                 1950             


Phe Tyr  Asp Asn Asp Leu Asn  Pro Val Met Asp Ala  Lys Ala Gln 
    1955                 1960                 1965             


Glu Trp  Cys Asp Arg Ile Gly  Arg Cys Lys Asp Ile  His Ile Tyr 
    1970                 1975                 1980             


Arg Leu  Val Ser Gly Asn Ser  Ile Glu Glu Lys Leu  Leu Lys Asn 
    1985                 1990                 1995             


Gly Thr  Lys Asp Leu Ile Arg  Glu Val Ala Ala Gln  Gly Asn Asp 
    2000                 2005                 2010             


Tyr Ser  Met Ala Phe Leu Thr  Gln Arg Thr Ile Gln  Glu Leu Phe 
    2015                 2020                 2025             


Glu Val  Tyr Ser Pro Met Asp  Asp Ala Gly Phe Pro  Val Lys Ala 
    2030                 2035                 2040             


Glu Glu  Phe Val Val Leu Ser  Gln Glu Pro Ser Val  Thr Glu Thr 
    2045                 2050                 2055             


Ile Ala  Pro Lys Ile Ala Arg  Pro Phe Ile Glu Ala  Leu Lys Ser 
    2060                 2065                 2070             


Ile Glu  Tyr Leu Glu Glu Asp  Ala Gln Lys Ser Ala  Gln Glu Gly 
    2075                 2080                 2085             


Val Leu  Gly Pro His Thr Asp  Ala Leu Ser Ser Asp  Ser Glu Asn 
    2090                 2095                 2100             


Met Pro  Cys Asp Glu Glu Pro  Ser Gln Leu Glu Glu  Leu Ala Asp 
    2105                 2110                 2115             


Phe Met  Glu Gln Leu Thr Pro  Ile Glu Lys Tyr Ala  Leu Asn Tyr 
    2120                 2125                 2130             


Leu Glu  Leu Phe His Thr Ser  Ile Glu Gln Glu Lys  Glu Arg Asn 
    2135                 2140                 2145             


Ser Glu  Asp Ala Val Met Thr  Ala Val Arg Ala Trp  Glu Phe Trp 
    2150                 2155                 2160             


Asn Leu  Lys Thr Leu Gln Glu  Arg Glu Ala Arg Leu  Arg Leu Glu 
    2165                 2170                 2175             


Gln Glu  Glu Ala Glu Leu Leu  Thr Tyr Thr Arg Glu  Asp Ala Tyr 
    2180                 2185                 2190             


Ser Met  Glu Tyr Val Tyr Glu  Asp Val Asp Gly Gln  Thr Glu Val 
    2195                 2200                 2205             


Met Pro  Leu Trp Thr Pro Pro  Thr Pro Pro Gln Asp  Asp Ser Asp 
    2210                 2215                 2220             


Ile Tyr  Leu Asp Ser Val Met  Cys Leu Met Tyr Glu  Ala Thr Pro 
    2225                 2230                 2235             


Ile Pro  Glu Ala Lys Leu Pro  Pro Val Tyr Val Arg  Lys Glu Arg 
    2240                 2245                 2250             


Lys Arg  His Lys Thr Asp Pro  Ser Ala Ala Gly Arg  Lys Lys Lys 
    2255                 2260                 2265             


Gln Arg  His Gly Glu Ala Val  Val Pro Pro Arg Ser  Leu Phe Asp 
    2270                 2275                 2280             


Arg Ala  Thr Pro Gly Leu Leu  Lys Ile Arg Arg Glu  Gly Lys Glu 
    2285                 2290                 2295             


Gln Lys  Lys Asn Ile Leu Leu  Lys Gln Gln Val Pro  Phe Ala Lys 
    2300                 2305                 2310             


Pro Leu  Pro Thr Phe Ala Lys  Pro Thr Ala Glu Pro  Gly Gln Asp 
    2315                 2320                 2325             


Asn Pro  Glu Trp Leu Ile Ser  Glu Asp Trp Ala Leu  Leu Gln Ala 
    2330                 2335                 2340             


Val Lys  Gln Leu Leu Glu Leu  Pro Leu Asn Leu Thr  Ile Val Ser 
    2345                 2350                 2355             


Pro Ala  His Thr Pro Asn Trp  Asp Leu Val Ser Asp  Val Val Asn 
    2360                 2365                 2370             


Ser Cys  Ser Arg Ile Tyr Arg  Ser Ser Lys Gln Cys  Arg Asn Arg 
    2375                 2380                 2385             


Tyr Glu  Asn Val Ile Ile Pro  Arg Glu Glu Gly Lys  Ser Lys Asn 
    2390                 2395                 2400             


Asn Arg  Pro Leu Arg Thr Ser  Gln Ile Tyr Ala Gln  Asp Glu Asn 
    2405                 2410                 2415             


Ala Thr  His Thr Gln Leu Tyr  Thr Ser His Phe Asp  Leu Met Lys 
    2420                 2425                 2430             


Met Thr  Ala Gly Lys Arg Ser  Pro Pro Ile Lys Pro  Leu Leu Gly 
    2435                 2440                 2445             


Met Asn  Pro Phe Gln Lys Asn  Pro Lys His Ala Ser  Val Leu Ala 
    2450                 2455                 2460             


Glu Ser  Gly Ile Asn Tyr Asp  Lys Pro Leu Pro Pro  Ile Gln Val 
    2465                 2470                 2475             


Ala Ser  Leu Arg Ala Glu Arg  Ile Ala Lys Glu Lys  Lys Ala Leu 
    2480                 2485                 2490             


Ala Asp  Gln Gln Lys Ala Gln  Gln Pro Ala Val Ala  Gln Pro Pro 
    2495                 2500                 2505             


Pro Pro  Gln Pro Gln Pro Pro  Pro Pro Pro Gln Gln  Pro Pro Pro 
    2510                 2515                 2520             


Pro Leu  Pro Gln Pro Gln Ala  Ala Gly Ser Gln Pro  Pro Ala Gly 
    2525                 2530                 2535             


Pro Pro  Ala Val Gln Pro Gln  Pro Gln Pro Gln Pro  Gln Thr Gln 
    2540                 2545                 2550             


Pro Gln  Pro Val Gln Ala Pro  Ala Lys Ala Gln Pro  Ala Ile Thr 
    2555                 2560                 2565             


Thr Gly  Gly Ser Ala Ala Val  Leu Ala Gly Thr Ile  Lys Thr Ser 
    2570                 2575                 2580             


Val Thr  Gly Thr Ser Met Pro  Thr Gly Ala Val Ser  Gly Asn Val 
    2585                 2590                 2595             


Ile Val  Asn Thr Ile Ala Gly  Val Pro Ala Ala Thr  Phe Gln Ser 
    2600                 2605                 2610             


Ile Asn  Lys Arg Leu Ala Ser  Pro Val Ala Pro Gly  Ala Leu Thr 
    2615                 2620                 2625             


Thr Pro  Gly Gly Ser Ala Pro  Ala Gln Val Val His  Thr Gln Pro 
    2630                 2635                 2640             


Pro Pro  Arg Ala Val Gly Ser  Pro Ala Thr Ala Thr  Pro Asp Leu 
    2645                 2650                 2655             


Val Ser  Met Ala Thr Thr Gln  Gly Val Arg Ala Val  Thr Ser Val 
    2660                 2665                 2670             


Thr Ala  Ser Ala Val Val Thr  Thr Asn Leu Thr Pro  Val Gln Thr 
    2675                 2680                 2685             


Pro Ala  Arg Ser Leu Val Pro  Gln Val Ser Gln Ala  Thr Gly Val 
    2690                 2695                 2700             


Gln Leu  Pro Gly Lys Thr Ile  Thr Pro Ala His Phe  Gln Leu Leu 
    2705                 2710                 2715             


Arg Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2720                 2725                 2730             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2735                 2740                 2745             


Thr Thr  Thr Thr Ser Gln Val  Gln Val Pro Gln Ile  Gln Gly Gln 
    2750                 2755                 2760             


Ala Gln  Ser Pro Ala Gln Ile  Lys Ala Val Gly Lys  Leu Thr Pro 
    2765                 2770                 2775             


Glu His  Leu Ile Lys Met Gln  Lys Gln Lys Leu Gln  Met Pro Pro 
    2780                 2785                 2790             


Gln Pro  Pro Pro Pro Gln Ala  Gln Ser Ala Pro Pro  Gln Pro Thr 
    2795                 2800                 2805             


Ala Gln  Val Gln Val Gln Thr  Ser Gln Pro Pro Gln  Gln Gln Ser 
    2810                 2815                 2820             


Pro Gln  Leu Thr Thr Val Thr  Ala Pro Arg Pro Gly  Ala Leu Leu 
    2825                 2830                 2835             


Thr Gly  Thr Thr Val Ala Asn  Leu Gln Val Ala Arg  Leu Thr Arg 
    2840                 2845                 2850             


Val Pro  Thr Ser Gln Leu Gln  Ala Gln Gly Gln Met  Gln Thr Gln 
    2855                 2860                 2865             


Ala Pro  Gln Pro Ala Gln Val  Ala Leu Ala Lys Pro  Pro Val Val 
    2870                 2875                 2880             


Ser Val  Pro Ala Ala Val Val  Ser Ser Pro Gly Val  Thr Thr Leu 
    2885                 2890                 2895             


Pro Met  Asn Val Ala Gly Ile  Ser Val Ala Ile Gly  Gln Pro Gln 
    2900                 2905                 2910             


Lys Ala  Ala Gly Gln Thr Val  Val Ala Gln Pro Val  His Met Gln 
    2915                 2920                 2925             


Gln Leu  Leu Lys Leu Lys Gln  Gln Ala Val Gln Gln  Gln Lys Ala 
    2930                 2935                 2940             


Ile Gln  Pro Gln Ala Ala Gln  Gly Pro Ala Ala Val  Gln Gln Lys 
    2945                 2950                 2955             


Ile Thr  Ala Gln Gln Ile Thr  Thr Pro Gly Ala Gln  Gln Lys Val 
    2960                 2965                 2970             


Ala Tyr  Ala Ala Gln Pro Ala  Leu Lys Thr Gln Phe  Leu Thr Thr 
    2975                 2980                 2985             


Pro Ile  Ser Gln Ala Gln Lys  Leu Ala Gly Ala Gln  Gln Val Gln 
    2990                 2995                 3000             


Thr Gln  Ile Gln Val Ala Lys  Leu Pro Gln Val Val  Gln Gln Gln 
    3005                 3010                 3015             


Thr Pro  Val Ala Ser Ile Gln  Gln Val Ala Ser Ala  Ser Gln Gln 
    3020                 3025                 3030             


Ala Ser  Pro Gln Thr Val Ala  Leu Thr Gln Ala Thr  Ala Ala Gly 
    3035                 3040                 3045             


Gln Gln  Val Gln Met Ile Pro  Ala Val Thr Ala Thr  Ala Gln Val 
    3050                 3055                 3060             


Val Gln  Gln Lys Leu Ile Gln  Gln Gln Val Val Thr  Thr Ala Ser 
    3065                 3070                 3075             


Ala Pro  Leu Gln Thr Pro Gly  Ala Pro Asn Pro Ala  Gln Val Pro 
    3080                 3085                 3090             


Ala Ser  Ser Asp Ser Pro Ser  Gln Gln Pro Lys Leu  Gln Met Arg 
    3095                 3100                 3105             


Val Pro  Ala Val Arg Leu Lys  Thr Pro Thr Lys Pro  Pro Cys Gln 
    3110                 3115                 3120             


<210>  3582
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPAS1__Homo_sapiens__NP_001421

<400>  3582

Met Thr Ala Asp Lys Glu Lys Lys Arg Ser Ser Ser Glu Arg Arg Lys 
1               5                   10                  15      


Glu Lys Ser Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys Glu Thr Glu 
            20                  25                  30          


Val Phe Tyr Glu Leu Ala His Glu Leu Pro Leu Pro His Ser Val Ser 
        35                  40                  45              


Ser His Leu Asp Lys Ala Ser Ile Met Arg Leu Ala Ile Ser Phe Leu 
    50                  55                  60                  


Arg Thr His Lys Leu Leu Ser Ser Val Cys Ser Glu Asn Glu Ser Glu 
65                  70                  75                  80  


Ala Glu Ala Asp Gln Gln Met Asp Asn Leu Tyr Leu Lys Ala Leu Glu 
                85                  90                  95      


Gly Phe Ile Ala Val Val Thr Gln Asp Gly Asp Met Ile Phe Leu Ser 
            100                 105                 110         


Glu Asn Ile Ser Lys Phe Met Gly Leu Thr Gln Val Glu Leu Thr Gly 
        115                 120                 125             


His Ser Ile Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Ile Arg 
    130                 135                 140                 


Glu Asn Leu Ser Leu Lys Asn Gly Ser Gly Phe Gly Lys Lys Ser Lys 
145                 150                 155                 160 


Asp Met Ser Thr Glu Arg Asp Phe Phe Met Arg Met Lys Cys Thr Val 
                165                 170                 175     


Thr Asn Arg Gly Arg Thr Val Asn Leu Lys Ser Ala Thr Trp Lys Val 
            180                 185                 190         


Leu His Cys Thr Gly Gln Val Lys Val Tyr Asn Asn Cys Pro Pro His 
        195                 200                 205             


Asn Ser Leu Cys Gly Tyr Lys Glu Pro Leu Leu Ser Cys Leu Ile Ile 
    210                 215                 220                 


Met Cys Glu Pro Ile Gln His Pro Ser His Met Asp Ile Pro Leu Asp 
225                 230                 235                 240 


Ser Lys Thr Phe Leu Ser Arg His Ser Met Asp Met Lys Phe Thr Tyr 
                245                 250                 255     


Cys Asp Asp Arg Ile Thr Glu Leu Ile Gly Tyr His Pro Glu Glu Leu 
            260                 265                 270         


Leu Gly Arg Ser Ala Tyr Glu Phe Tyr His Ala Leu Asp Ser Glu Asn 
        275                 280                 285             


Met Thr Lys Ser His Gln Asn Leu Cys Thr Lys Gly Gln Val Val Ser 
    290                 295                 300                 


Gly Gln Tyr Arg Met Leu Ala Lys His Gly Gly Tyr Val Trp Leu Glu 
305                 310                 315                 320 


Thr Gln Gly Thr Val Ile Tyr Asn Pro Arg Asn Leu Gln Pro Gln Cys 
                325                 330                 335     


Ile Met Cys Val Asn Tyr Val Leu Ser Glu Ile Glu Lys Asn Asp Val 
            340                 345                 350         


Val Phe Ser Met Asp Gln Thr Glu Ser Leu Phe Lys Pro His Leu Met 
        355                 360                 365             


Ala Met Asn Ser Ile Phe Asp Ser Ser Gly Lys Gly Ala Val Ser Glu 
    370                 375                 380                 


Lys Ser Asn Phe Leu Phe Thr Lys Leu Lys Glu Glu Pro Glu Glu Leu 
385                 390                 395                 400 


Ala Gln Leu Ala Pro Thr Pro Gly Asp Ala Ile Ile Ser Leu Asp Phe 
                405                 410                 415     


Gly Asn Gln Asn Phe Glu Glu Ser Ser Ala Tyr Gly Lys Ala Ile Leu 
            420                 425                 430         


Pro Pro Ser Gln Pro Trp Ala Thr Glu Leu Arg Ser His Ser Thr Gln 
        435                 440                 445             


Ser Glu Ala Gly Ser Leu Pro Ala Phe Thr Val Pro Gln Ala Ala Ala 
    450                 455                 460                 


Pro Gly Ser Thr Thr Pro Ser Ala Thr Ser Ser Ser Ser Ser Cys Ser 
465                 470                 475                 480 


Thr Pro Asn Ser Pro Glu Asp Tyr Tyr Thr Ser Leu Asp Asn Asp Leu 
                485                 490                 495     


Lys Ile Glu Val Ile Glu Lys Leu Phe Ala Met Asp Thr Glu Ala Lys 
            500                 505                 510         


Asp Gln Cys Ser Thr Gln Thr Asp Phe Asn Glu Leu Asp Leu Glu Thr 
        515                 520                 525             


Leu Ala Pro Tyr Ile Pro Met Asp Gly Glu Asp Phe Gln Leu Ser Pro 
    530                 535                 540                 


Ile Cys Pro Glu Glu Arg Leu Leu Ala Glu Asn Pro Gln Ser Thr Pro 
545                 550                 555                 560 


Gln His Cys Phe Ser Ala Met Thr Asn Ile Phe Gln Pro Leu Ala Pro 
                565                 570                 575     


Val Ala Pro His Ser Pro Phe Leu Leu Asp Lys Phe Gln Gln Gln Leu 
            580                 585                 590         


Glu Ser Lys Lys Thr Glu Pro Glu His Arg Pro Met Ser Ser Ile Phe 
        595                 600                 605             


Phe Asp Ala Gly Ser Lys Ala Ser Leu Pro Pro Cys Cys Gly Gln Ala 
    610                 615                 620                 


Ser Thr Pro Leu Ser Ser Met Gly Gly Arg Ser Asn Thr Gln Trp Pro 
625                 630                 635                 640 


Pro Asp Pro Pro Leu His Phe Gly Pro Thr Lys Trp Ala Val Gly Asp 
                645                 650                 655     


Gln Arg Thr Glu Phe Leu Gly Ala Ala Pro Leu Gly Pro Pro Val Ser 
            660                 665                 670         


Pro Pro His Val Ser Thr Phe Lys Thr Arg Ser Ala Lys Gly Phe Gly 
        675                 680                 685             


Ala Arg Gly Pro Asp Val Leu Ser Pro Ala Met Val Ala Leu Ser Asn 
    690                 695                 700                 


Lys Leu Lys Leu Lys Arg Gln Leu Glu Tyr Glu Glu Gln Ala Phe Gln 
705                 710                 715                 720 


Asp Leu Ser Gly Gly Asp Pro Pro Gly Gly Ser Thr Ser His Leu Met 
                725                 730                 735     


Trp Lys Arg Met Lys Asn Leu Arg Gly Gly Ser Cys Pro Leu Met Pro 
            740                 745                 750         


Asp Lys Pro Leu Ser Ala Asn Val Pro Asn Asp Lys Phe Thr Gln Asn 
        755                 760                 765             


Pro Met Arg Gly Leu Gly His Pro Leu Arg His Leu Pro Leu Pro Gln 
    770                 775                 780                 


Pro Pro Ser Ala Ile Ser Pro Gly Glu Asn Ser Lys Ser Arg Phe Pro 
785                 790                 795                 800 


Pro Gln Cys Tyr Ala Thr Gln Tyr Gln Asp Tyr Ser Leu Ser Ser Ala 
                805                 810                 815     


His Lys Val Ser Gly Met Ala Ser Arg Leu Leu Gly Pro Ser Phe Glu 
            820                 825                 830         


Ser Tyr Leu Leu Pro Glu Leu Thr Arg Tyr Asp Cys Glu Val Asn Val 
        835                 840                 845             


Pro Val Leu Gly Ser Ser Thr Leu Leu Gln Gly Gly Asp Leu Leu Arg 
    850                 855                 860                 


Ala Leu Asp Gln Ala Thr 
865                 870 


<210>  3583
<211>  880
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPB41L1__Homo_sapiens__NP_001245258

<400>  3583

Met Thr Thr Glu Thr Gly Pro Asp Ser Glu Val Lys Lys Ala Gln Glu 
1               5                   10                  15      


Glu Ala Pro Gln Gln Pro Glu Ala Ala Ala Ala Val Thr Thr Pro Val 
            20                  25                  30          


Thr Pro Ala Gly His Gly His Pro Glu Ala Asn Ser Asn Glu Lys His 
        35                  40                  45              


Pro Ser Gln Gln Asp Thr Arg Pro Ala Glu Gln Ser Leu Asp Met Glu 
    50                  55                  60                  


Glu Lys Asp Tyr Ser Glu Ala Asp Gly Leu Ser Glu Arg Thr Thr Pro 
65                  70                  75                  80  


Ser Lys Ala Gln Lys Ser Pro Gln Lys Ile Ala Lys Lys Tyr Lys Ser 
                85                  90                  95      


Ala Ile Cys Arg Val Thr Leu Leu Asp Ala Ser Glu Tyr Glu Cys Glu 
            100                 105                 110         


Val Glu Lys His Gly Arg Gly Gln Val Leu Phe Asp Leu Val Cys Glu 
        115                 120                 125             


His Leu Asn Leu Leu Glu Lys Asp Tyr Phe Gly Leu Thr Phe Cys Asp 
    130                 135                 140                 


Ala Asp Ser Gln Lys Asn Trp Leu Asp Pro Ser Lys Glu Ile Lys Lys 
145                 150                 155                 160 


Gln Ile Arg Ser Ser Pro Trp Asn Phe Ala Phe Thr Val Lys Phe Tyr 
                165                 170                 175     


Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr Leu 
            180                 185                 190         


Cys Leu Gln Leu Arg Ala Asp Ile Ile Thr Gly Arg Leu Pro Cys Ser 
        195                 200                 205             


Phe Val Thr His Ala Leu Leu Gly Ser Tyr Ala Val Gln Ala Glu Leu 
    210                 215                 220                 


Gly Asp Tyr Asp Ala Glu Glu His Val Gly Asn Tyr Val Ser Glu Leu 
225                 230                 235                 240 


Arg Phe Ala Pro Asn Gln Thr Arg Glu Leu Glu Glu Arg Ile Met Glu 
                245                 250                 255     


Leu His Lys Thr Tyr Arg Gly Met Thr Pro Gly Glu Ala Glu Ile His 
            260                 265                 270         


Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His 
        275                 280                 285             


His Ala Lys Asp Ser Glu Gly Ile Asp Ile Met Leu Gly Val Cys Ala 
    290                 295                 300                 


Asn Gly Leu Leu Ile Tyr Arg Asp Arg Leu Arg Ile Asn Arg Phe Ala 
305                 310                 315                 320 


Trp Pro Lys Ile Leu Lys Ile Ser Tyr Lys Arg Ser Asn Phe Tyr Ile 
                325                 330                 335     


Lys Ile Arg Pro Gly Glu Tyr Glu Gln Phe Glu Ser Thr Ile Gly Phe 
            340                 345                 350         


Lys Leu Pro Asn His Arg Ser Ala Lys Arg Leu Trp Lys Val Cys Ile 
        355                 360                 365             


Glu His His Thr Phe Phe Arg Leu Val Ser Pro Glu Pro Pro Pro Lys 
    370                 375                 380                 


Gly Phe Leu Val Met Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln 
385                 390                 395                 400 


Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro Phe 
                405                 410                 415     


Phe Glu Arg Ser Ser Ser Lys Arg Tyr Thr Met Ser Arg Ser Leu Asp 
            420                 425                 430         


Gly Ala Glu Phe Ser Arg Pro Ala Ser Val Ser Glu Asn His Asp Ala 
        435                 440                 445             


Gly Pro Asp Gly Asp Lys Arg Asp Glu Asp Gly Glu Ser Gly Gly Gln 
    450                 455                 460                 


Arg Ser Glu Ala Glu Glu Gly Glu Val Arg Thr Pro Thr Lys Ile Lys 
465                 470                 475                 480 


Glu Leu Lys Pro Glu Gln Glu Thr Thr Pro Arg His Lys Gln Glu Phe 
                485                 490                 495     


Leu Asp Lys Pro Glu Asp Val Leu Leu Lys His Gln Ala Ser Ile Asn 
            500                 505                 510         


Glu Leu Lys Arg Thr Leu Lys Glu Pro Asn Ser Lys Leu Ile His Arg 
        515                 520                 525             


Asp Arg Asp Trp Glu Arg Glu Arg Arg Leu Pro Ser Ser Pro Ala Ser 
    530                 535                 540                 


Pro Ser Pro Lys Gly Thr Pro Glu Lys Ala Asn Glu Arg Ala Gly Leu 
545                 550                 555                 560 


Arg Glu Gly Ser Glu Glu Lys Val Lys Pro Pro Arg Pro Arg Ala Pro 
                565                 570                 575     


Glu Ser Asp Thr Gly Asp Glu Asp Gln Asp Gln Glu Arg Asp Thr Val 
            580                 585                 590         


Phe Leu Lys Asp Asn His Leu Ala Ile Glu Arg Lys Cys Ser Ser Ile 
        595                 600                 605             


Thr Val Ser Ser Thr Ser Ser Leu Glu Ala Glu Val Asp Phe Thr Val 
    610                 615                 620                 


Ile Gly Asp Tyr His Gly Ser Ala Phe Glu Asp Phe Ser Arg Ser Leu 
625                 630                 635                 640 


Pro Glu Leu Asp Arg Asp Lys Ser Asp Ser Asp Thr Glu Gly Leu Leu 
                645                 650                 655     


Phe Ser Arg Asp Leu Asn Lys Gly Ala Pro Ser Gln Asp Asp Glu Ser 
            660                 665                 670         


Gly Gly Ile Glu Asp Ser Pro Asp Arg Gly Ala Cys Ser Thr Pro Asp 
        675                 680                 685             


Met Pro Gln Phe Glu Pro Val Lys Thr Glu Thr Met Thr Val Ser Ser 
    690                 695                 700                 


Leu Ala Ile Arg Lys Lys Ile Glu Pro Glu Ala Val Leu Gln Thr Arg 
705                 710                 715                 720 


Val Ser Ala Met Asp Asn Thr Gln Val Asp Gly Ser Ala Ser Val Gly 
                725                 730                 735     


Arg Glu Phe Ile Ala Thr Thr Pro Ser Ile Thr Thr Glu Thr Ile Ser 
            740                 745                 750         


Thr Thr Met Glu Asn Ser Leu Lys Ser Gly Lys Gly Ala Ala Ala Met 
        755                 760                 765             


Ile Pro Gly Pro Gln Thr Val Ala Thr Glu Ile Arg Ser Leu Ser Pro 
    770                 775                 780                 


Ile Ile Gly Lys Asp Val Leu Thr Ser Thr Tyr Gly Ala Thr Ala Glu 
785                 790                 795                 800 


Thr Leu Ser Thr Ser Thr Thr Thr His Val Thr Lys Thr Val Lys Gly 
                805                 810                 815     


Gly Phe Ser Glu Thr Arg Ile Glu Lys Arg Ile Ile Ile Thr Gly Asp 
            820                 825                 830         


Glu Asp Val Asp Gln Asp Gln Ala Leu Ala Leu Ala Ile Lys Glu Ala 
        835                 840                 845             


Lys Leu Gln His Pro Asp Met Leu Val Thr Lys Ala Val Val Tyr Arg 
    850                 855                 860                 


Glu Thr Asp Pro Ser Pro Glu Glu Arg Asp Lys Lys Pro Gln Glu Ser 
865                 870                 875                 880 


<210>  3584
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPB41L2__Homo_sapiens__NP_001129026

<400>  3584

Met Thr Thr Glu Val Gly Ser Val Ser Glu Val Lys Lys Asp Ser Ser 
1               5                   10                  15      


Gln Leu Gly Thr Asp Ala Thr Lys Glu Lys Pro Lys Glu Val Ala Glu 
            20                  25                  30          


Asn Gln Gln Asn Gln Ser Ser Asp Pro Glu Glu Glu Lys Gly Ser Gln 
        35                  40                  45              


Pro Pro Pro Ala Ala Glu Ser Gln Ser Ser Leu Arg Arg Gln Lys Arg 
    50                  55                  60                  


Glu Lys Glu Thr Ser Glu Ser Arg Gly Ile Ser Arg Phe Ile Pro Pro 
65                  70                  75                  80  


Trp Leu Lys Lys Gln Lys Ser Tyr Thr Leu Val Val Ala Lys Asp Gly 
                85                  90                  95      


Gly Asp Lys Lys Glu Pro Thr Gln Ala Val Val Glu Glu Gln Val Leu 
            100                 105                 110         


Asp Lys Glu Glu Pro Leu Pro Glu Glu Gln Arg Gln Ala Lys Gly Asp 
        115                 120                 125             


Ala Glu Glu Met Ala Gln Lys Lys Gln Glu Ile Lys Val Glu Val Lys 
    130                 135                 140                 


Glu Glu Lys Pro Ser Val Ser Lys Glu Glu Lys Pro Ser Val Ser Lys 
145                 150                 155                 160 


Val Glu Met Gln Pro Thr Glu Leu Val Ser Lys Glu Arg Glu Glu Lys 
                165                 170                 175     


Val Lys Glu Thr Gln Glu Asp Lys Leu Glu Gly Gly Ala Ala Lys Arg 
            180                 185                 190         


Glu Thr Lys Glu Val Gln Thr Asn Glu Leu Lys Ala Glu Lys Ala Ser 
        195                 200                 205             


Gln Lys Val Thr Lys Lys Thr Lys Thr Val Gln Cys Lys Val Thr Leu 
    210                 215                 220                 


Leu Asp Gly Thr Glu Tyr Ser Cys Asp Leu Glu Lys His Ala Lys Gly 
225                 230                 235                 240 


Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn Leu Leu Glu Lys 
                245                 250                 255     


Asp Tyr Phe Gly Leu Leu Phe Gln Glu Ser Pro Glu Gln Lys Asn Trp 
            260                 265                 270         


Leu Asp Pro Ala Lys Glu Ile Lys Arg Gln Leu Arg Asn Leu Pro Trp 
        275                 280                 285             


Leu Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro Asp Pro Ser Gln Leu 
    290                 295                 300                 


Thr Glu Asp Ile Thr Arg Tyr Phe Leu Cys Leu Gln Leu Arg Gln Asp 
305                 310                 315                 320 


Ile Ala Ser Gly Arg Leu Pro Cys Ser Phe Val Thr His Ala Leu Leu 
                325                 330                 335     


Gly Ser Tyr Thr Leu Gln Ala Glu Leu Gly Asp Tyr Asp Pro Glu Glu 
            340                 345                 350         


His Gly Ser Ile Asp Leu Ser Glu Phe Gln Phe Ala Pro Thr Gln Thr 
        355                 360                 365             


Lys Glu Leu Glu Glu Lys Val Ala Glu Leu His Lys Thr His Arg Gly 
    370                 375                 380                 


Leu Ser Pro Ala Gln Ala Asp Ser Gln Phe Leu Glu Asn Ala Lys Arg 
385                 390                 395                 400 


Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys Asp Ser Glu Gly 
                405                 410                 415     


Val Asp Ile Lys Leu Gly Val Cys Ala Asn Gly Leu Leu Ile Tyr Lys 
            420                 425                 430         


Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys Ile Leu Lys Ile 
        435                 440                 445             


Ser Tyr Lys Arg Ser Asn Phe Tyr Ile Lys Val Arg Pro Ala Glu Leu 
    450                 455                 460                 


Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro Asn His Arg Ala 
465                 470                 475                 480 


Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His Thr Phe Tyr Arg 
                485                 490                 495     


Leu Val Ser Pro Glu Gln Pro Pro Lys Ala Lys Phe Leu Thr Leu Gly 
            500                 505                 510         


Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr Arg Gln Ala 
        515                 520                 525             


Ser Thr Leu Ile Asp Arg Pro Ala Pro His Phe Glu Arg Thr Ser Ser 
    530                 535                 540                 


Lys Arg Val Ser Arg Ser Leu Asp Gly Ala Pro Ile Gly Val Met Asp 
545                 550                 555                 560 


Gln Ser Leu Met Lys Asp Phe Pro Gly Ala Ala Gly Glu Ile Ser Ala 
                565                 570                 575     


Tyr Gly Pro Gly Leu Val Ser Ile Ala Val Val Gln Asp Gly Asp Gly 
            580                 585                 590         


Arg Arg Glu Val Arg Ser Pro Thr Lys Ala Pro His Leu Gln Leu Ile 
        595                 600                 605             


Glu Gly Lys Thr Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys 
    610                 615                 620                 


Arg Ile Val Ile Thr Gly Asp Gly Asp Ile Asp His Asp Gln Ala Leu 
625                 630                 635                 640 


Ala Gln Ala Ile Arg Glu Ala Arg Glu Gln His Pro Asp Met Ser Val 
                645                 650                 655     


Thr Arg Val Val Val His Lys Glu Thr Glu Leu Ala Glu Glu Gly Glu 
            660                 665                 670         


Asp 
    


<210>  3585
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPB41L3__Homo_sapiens__NP_001268462

<400>  3585

Met Thr Thr Glu Ser Gly Ser Asp Ser Glu Ser Lys Pro Asp Gln Glu 
1               5                   10                  15      


Ala Glu Pro Gln Glu Ala Ala Gly Ala Gln Gly Arg Ala Gly Ala Pro 
            20                  25                  30          


Val Pro Glu Pro Pro Lys Glu Glu Gln Gln Gln Ala Leu Glu Gln Phe 
        35                  40                  45              


Ala Ala Ala Ala Ala His Ser Thr Pro Val Arg Arg Glu Val Thr Asp 
    50                  55                  60                  


Lys Glu Gln Glu Phe Ala Ala Arg Ala Ala Lys Gln Leu Glu Tyr Gln 
65                  70                  75                  80  


Gln Leu Glu Asp Asp Lys Leu Ser Gln Lys Ser Ser Ser Ser Lys Leu 
                85                  90                  95      


Ser Arg Ser Pro Leu Lys Ile Val Lys Lys Pro Lys Ser Met Gln Cys 
            100                 105                 110         


Lys Val Ile Leu Leu Asp Gly Ser Glu Tyr Thr Cys Asp Val Glu Lys 
        115                 120                 125             


Arg Ser Arg Gly Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn 
    130                 135                 140                 


Leu Leu Glu Lys Asp Tyr Phe Gly Leu Thr Tyr Arg Asp Ala Glu Asn 
145                 150                 155                 160 


Gln Lys Asn Trp Leu Asp Pro Ala Lys Glu Ile Lys Lys Gln Val Arg 
                165                 170                 175     


Ser Gly Ala Trp His Phe Ser Phe Asn Val Lys Phe Tyr Pro Pro Asp 
            180                 185                 190         


Pro Ala Gln Leu Ser Glu Asp Ile Thr Arg Tyr Tyr Leu Cys Leu Gln 
        195                 200                 205             


Leu Arg Asp Asp Ile Val Ser Gly Arg Leu Pro Cys Ser Phe Val Thr 
    210                 215                 220                 


Leu Ala Leu Leu Gly Ser Tyr Thr Val Gln Ser Glu Leu Gly Asp Tyr 
225                 230                 235                 240 


Asp Pro Asp Glu Cys Gly Ser Asp Tyr Ile Ser Glu Phe Arg Phe Ala 
                245                 250                 255     


Pro Asn His Thr Lys Glu Leu Glu Asp Lys Val Ile Glu Leu His Lys 
            260                 265                 270         


Ser His Arg Gly Met Thr Pro Ala Glu Ala Glu Met His Phe Leu Glu 
        275                 280                 285             


Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys 
    290                 295                 300                 


Asp Ser Glu Gly Val Glu Ile Met Leu Gly Val Cys Ala Ser Gly Leu 
305                 310                 315                 320 


Leu Ile Tyr Arg Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys 
                325                 330                 335     


Val Leu Lys Ile Ser Tyr Lys Arg Asn Asn Phe Tyr Ile Lys Ile Arg 
            340                 345                 350         


Pro Gly Glu Phe Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro 
        355                 360                 365             


Asn His Arg Ala Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His 
    370                 375                 380                 


Thr Phe Phe Arg Leu Leu Leu Pro Glu Ala Pro Pro Lys Lys Phe Leu 
385                 390                 395                 400 


Thr Leu Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr 
                405                 410                 415     


Arg Arg Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro Tyr Phe Glu Arg 
            420                 425                 430         


Ser Ser Ser Lys Arg Tyr Thr Met Ser Arg Ser Leu Asp Gly Ala Ser 
        435                 440                 445             


Val Asn Glu Asn His Glu Ile Tyr Met Lys Asp Ser Met Ser Ala Ala 
    450                 455                 460                 


Glu Val Gly Thr Gly Gln Tyr Ala Thr Thr Lys Gly Ile Ser Gln Thr 
465                 470                 475                 480 


Asn Leu Ile Thr Thr Val Thr Pro Glu Lys Lys Ala Glu Glu Glu Arg 
                485                 490                 495     


Asp Glu Glu Glu Asp Lys Arg Arg Lys Gly Glu Glu Val Thr Pro Ile 
            500                 505                 510         


Ser Ala Ile Arg His Glu Gly Lys Thr Asp Ser Glu Arg Thr Asp Thr 
        515                 520                 525             


Ala Ala Asp Gly Glu Thr Thr Ala Thr Glu Ser Asp Gln Glu Glu Asp 
    530                 535                 540                 


Ala Glu Leu Lys Ala Gln Glu Leu Glu Lys Thr Gln Asp Asp Leu Met 
545                 550                 555                 560 


Lys His Gln Thr Asn Ile Ser Glu Leu Lys Arg Thr Phe Leu Glu Thr 
                565                 570                 575     


Ser Thr Asp Thr Ala Val Thr Asn Glu Trp Glu Lys Arg Leu Ser Thr 
            580                 585                 590         


Ser Pro Val Arg Leu Ala Ala Arg Gln Glu Asp Ala Pro Met Ile Glu 
        595                 600                 605             


Pro Leu Val Pro Glu Glu Thr Lys Gln Ser Ser Gly Glu Lys Leu Met 
    610                 615                 620                 


Asp Gly Ser Glu Ile Phe Ser Leu Leu Glu Ser Ala Arg Lys Pro Thr 
625                 630                 635                 640 


Glu Phe Ile Gly Gly Val Thr Ser Thr Ser Gln Ser Trp Val Gln Lys 
                645                 650                 655     


Met Glu Thr Lys Thr Glu Ser Ser Gly Ile Glu Thr Glu Pro Thr Val 
            660                 665                 670         


His His Leu Pro Leu Ser Thr Glu Lys Val Val Gln Glu Thr Val Leu 
        675                 680                 685             


Val Glu Glu Arg Arg Val Val His Ala Ser Gly Asp Ala Ser Tyr Ser 
    690                 695                 700                 


Ala Gly Asp Ser Gly Asp Ala Ala Ala Gln Pro Ala Phe Thr Gly Ile 
705                 710                 715                 720 


Lys Gly Lys Glu Gly Ser Ala Leu Thr Glu Gly Ala Lys Glu Glu Gly 
                725                 730                 735     


Gly Glu Glu Val Ala Lys Ala Val Leu Glu Gln Glu Glu Thr Ala Ala 
            740                 745                 750         


Ala Ser Arg Glu Arg Gln Glu Glu Gln Ser Ala Ala Ile His Ile Ser 
        755                 760                 765             


Glu Thr Leu Glu Gln Lys Pro His Phe Glu Ser Ser Thr Val Lys Thr 
    770                 775                 780                 


Glu Thr Ile Ser Phe Gly Ser Val Ser Pro Gly Gly Val Lys Leu Glu 
785                 790                 795                 800 


Ile Ser Thr Lys Glu Val Pro Val Val His Thr Glu Thr Lys Thr Ile 
                805                 810                 815     


Thr Tyr Glu Ser Ser Gln Val Asp Pro Gly Thr Asp Leu Glu Pro Gly 
            820                 825                 830         


Val Leu Met Ser Ala Gln Thr Ile Thr Ser Glu Thr Thr Ser Thr Thr 
        835                 840                 845             


Thr Thr Thr His Ile Thr Lys Thr Val Lys Gly Gly Ile Ser Glu Thr 
    850                 855                 860                 


Arg Ile Glu Lys Arg Ile Val Ile Thr Gly Asp Ala Asp Ile Asp His 
865                 870                 875                 880 


Asp Gln Glu 
            


<210>  3586
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPB41L4A__Homo_sapiens__NP_071423

<400>  3586

Met Gly Cys Phe Cys Ala Val Pro Glu Glu Phe Tyr Cys Glu Val Leu 
1               5                   10                  15      


Leu Leu Asp Glu Ser Lys Leu Thr Leu Thr Thr Gln Gln Gln Gly Ile 
            20                  25                  30          


Lys Lys Ser Thr Lys Gly Ser Val Val Leu Asp His Val Phe His His 
        35                  40                  45              


Val Asn Leu Val Glu Ile Asp Tyr Phe Gly Leu Arg Tyr Cys Asp Arg 
    50                  55                  60                  


Ser His Gln Thr Tyr Trp Leu Asp Pro Ala Lys Thr Leu Ala Glu His 
65                  70                  75                  80  


Lys Glu Leu Ile Asn Thr Gly Pro Pro Tyr Thr Leu Tyr Phe Gly Ile 
                85                  90                  95      


Lys Phe Tyr Ala Glu Asp Pro Cys Lys Leu Lys Glu Glu Ile Thr Arg 
            100                 105                 110         


Tyr Gln Phe Phe Leu Gln Val Lys Gln Asp Val Leu Gln Gly Arg Leu 
        115                 120                 125             


Pro Cys Pro Val Asn Thr Ala Ala Gln Leu Gly Ala Tyr Ala Ile Gln 
    130                 135                 140                 


Ser Glu Leu Gly Asp Tyr Asp Pro Tyr Lys His Thr Ala Gly Tyr Val 
145                 150                 155                 160 


Ser Glu Tyr Arg Phe Val Pro Asp Gln Lys Glu Glu Leu Glu Glu Ala 
                165                 170                 175     


Ile Glu Arg Ile His Lys Thr Leu Met Gly Gln Ile Pro Ser Glu Ala 
            180                 185                 190         


Glu Leu Asn Tyr Leu Arg Thr Ala Lys Ser Leu Glu Met Tyr Gly Val 
        195                 200                 205             


Asp Leu His Pro Val Tyr Gly Glu Asn Lys Ser Glu Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Thr Pro Val Gly Val Val Val Tyr Lys Asn Lys Lys Gln Val Gly 
225                 230                 235                 240 


Lys Tyr Phe Trp Pro Arg Ile Thr Lys Val His Phe Lys Glu Thr Gln 
                245                 250                 255     


Phe Glu Leu Arg Val Leu Gly Lys Asp Cys Asn Glu Thr Ser Phe Phe 
            260                 265                 270         


Phe Glu Ala Arg Ser Lys Thr Ala Cys Lys His Leu Trp Lys Cys Ser 
        275                 280                 285             


Val Glu His His Thr Phe Phe Arg Met Pro Glu Asn Glu Ser Asn Ser 
    290                 295                 300                 


Leu Ser Arg Lys Leu Ser Lys Phe Gly Ser Ile Arg Tyr Lys His Arg 
305                 310                 315                 320 


Tyr Ser Gly Arg Thr Ala Leu Gln Met Ser Arg Asp Leu Ser Ile Gln 
                325                 330                 335     


Leu Pro Arg Pro Asp Gln Asn Val Thr Arg Ser Arg Ser Lys Thr Tyr 
            340                 345                 350         


Pro Lys Arg Ile Ala Gln Thr Gln Pro Ala Glu Ser Asn Ser Ile Ser 
        355                 360                 365             


Arg Ile Thr Ala Asn Met Glu Asn Gly Glu Asn Glu Gly Thr Ile Lys 
    370                 375                 380                 


Ile Ile Ala Pro Ser Pro Val Lys Ser Phe Lys Lys Ala Lys Asn Glu 
385                 390                 395                 400 


Asn Ser Pro Asp Thr Gln Arg Ser Lys Ser His Ala Pro Trp Glu Glu 
                405                 410                 415     


Asn Gly Pro Gln Ser Gly Leu Tyr Asn Ser Pro Ser Asp Arg Thr Lys 
            420                 425                 430         


Ser Pro Lys Phe Pro Tyr Thr Arg Arg Arg Asn Pro Ser Cys Gly Ser 
        435                 440                 445             


Asp Asn Asp Ser Val Gln Pro Val Arg Arg Arg Lys Ala His Asn Ser 
    450                 455                 460                 


Gly Glu Asp Ser Asp Leu Lys Gln Arg Arg Arg Ser Arg Ser Arg Cys 
465                 470                 475                 480 


Asn Thr Ser Ser Gly Ser Glu Ser Glu Asn Ser Asn Arg Glu Tyr Arg 
                485                 490                 495     


Lys Lys Arg Asn Arg Ile Arg Gln Glu Asn Asp Met Val Asp Ser Ala 
            500                 505                 510         


Pro Gln Trp Glu Ala Val Leu Arg Arg Gln Lys Glu Lys Asn Gln Ala 
        515                 520                 525             


Asp Pro Asn Asn Arg Arg Ser Arg His Arg Ser Arg Ser Arg Ser Pro 
    530                 535                 540                 


Asp Ile Gln Ala Lys Glu Glu Leu Trp Lys His Ile Gln Lys Glu Leu 
545                 550                 555                 560 


Val Asp Pro Ser Gly Leu Ser Glu Glu Gln Leu Lys Glu Ile Pro Tyr 
                565                 570                 575     


Thr Lys Ile Glu Thr Gln Gly Asp Pro Ile Arg Ile Arg His Ser His 
            580                 585                 590         


Ser Pro Arg Ser Tyr Arg Gln Tyr Arg Arg Ser Gln Cys Ser Asp Gly 
        595                 600                 605             


Glu Arg Ser Val Leu Ser Glu Val Asn Ser Lys Thr Asp Leu Val Pro 
    610                 615                 620                 


Pro Leu Pro Val Thr His Ser Ser Asp Ala Gln Gly Ser Gly Asp Ala 
625                 630                 635                 640 


Thr Val His Gln Arg Arg Asn Gly Ser Lys Asp Ser Leu Met Glu Glu 
                645                 650                 655     


Lys Pro Gln Thr Ser Thr Asn Asn Leu Ala Gly Lys His Thr Ala Lys 
            660                 665                 670         


Thr Ile Lys Thr Ile Gln Ala Ser Arg Leu Lys Thr Glu Thr 
        675                 680                 685     


<210>  3587
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPB41L4B__Homo_sapiens__NP_060894

<400>  3587

Met Leu Arg Phe Leu Arg Arg Thr Phe Gly Arg Arg Ser Met Gln Arg 
1               5                   10                  15      


Tyr Ala Arg Gly Ala Ala Gly Arg Gly Ala Ala Gly Leu Gly Asp Glu 
            20                  25                  30          


Arg Asp Gly Gly Pro Arg Gly Gly Pro Ala Ala Ala Ala Ser Ser Ser 
        35                  40                  45              


Ala Leu Pro Ala Ala Pro Gly Gly Ser Val Phe Pro Ala Gly Gly Gly 
    50                  55                  60                  


Pro Leu Leu Thr Gly Gly Ala Ala Val His Ile Ser Ala Ala Gly Ala 
65                  70                  75                  80  


Ala Lys Ala Thr Leu Tyr Cys Arg Val Phe Leu Leu Asp Gly Thr Glu 
                85                  90                  95      


Val Ser Val Asp Leu Pro Lys His Ala Lys Gly Gln Asp Leu Phe Asp 
            100                 105                 110         


Gln Ile Val Tyr His Leu Asp Leu Val Glu Thr Asp Tyr Phe Gly Leu 
        115                 120                 125             


Gln Phe Leu Asp Ser Ala Gln Val Ala His Trp Leu Asp His Ala Lys 
    130                 135                 140                 


Pro Ile Lys Lys Gln Met Lys Ile Gly Pro Ala Tyr Ala Leu His Phe 
145                 150                 155                 160 


Arg Val Lys Tyr Tyr Ser Ser Glu Pro Asn Asn Leu Arg Glu Glu Phe 
                165                 170                 175     


Thr Arg Tyr Leu Phe Val Leu Gln Leu Arg His Asp Ile Leu Ser Gly 
            180                 185                 190         


Lys Leu Lys Cys Pro Tyr Glu Thr Ala Val Glu Leu Ala Ala Leu Cys 
        195                 200                 205             


Leu Gln Ala Glu Leu Gly Glu Cys Glu Leu Pro Glu His Thr Pro Glu 
    210                 215                 220                 


Leu Val Ser Glu Phe Arg Phe Ile Pro Asn Gln Thr Glu Ala Met Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Gln Arg Trp Lys Glu Cys Arg Gly Lys Ser Pro Ala 
                245                 250                 255     


Gln Ala Glu Leu Ser Tyr Leu Asn Lys Ala Lys Trp Leu Glu Met Tyr 
            260                 265                 270         


Gly Val Asp Met His Val Val Arg Gly Arg Asp Gly Cys Glu Tyr Ser 
        275                 280                 285             


Leu Gly Leu Thr Pro Thr Gly Ile Leu Ile Phe Glu Gly Ala Asn Lys 
    290                 295                 300                 


Ile Gly Leu Phe Phe Trp Pro Lys Ile Thr Lys Met Asp Phe Lys Lys 
305                 310                 315                 320 


Ser Lys Leu Thr Leu Val Val Val Glu Asp Asp Asp Gln Gly Arg Glu 
                325                 330                 335     


Gln Glu His Thr Phe Val Phe Arg Leu Asp Ser Ala Arg Thr Cys Lys 
            340                 345                 350         


His Leu Trp Lys Cys Ala Val Glu His His Ala Phe Phe Arg Leu Arg 
        355                 360                 365             


Thr Pro Gly Asn Ser Lys Ser Asn Arg Ser Asp Phe Ile Arg Leu Gly 
    370                 375                 380                 


Ser Arg Phe Arg Phe Ser Gly Arg Thr Glu Tyr Gln Ala Thr His Gly 
385                 390                 395                 400 


Ser Arg Leu Arg Arg Thr Ser Thr Phe Glu Arg Lys Pro Ser Lys Arg 
                405                 410                 415     


Tyr Pro Ser Arg Arg His Ser Thr Phe Lys Ala Ser Asn Pro Val Ile 
            420                 425                 430         


Ala Ala Gln Leu Cys Ser Lys Thr Asn Pro Glu Val His Asn Tyr Gln 
        435                 440                 445             


Pro Gln Tyr His Pro Asn Ile His Pro Ser Gln Pro Arg Trp His Pro 
    450                 455                 460                 


His Ser Pro Asn Val Arg Pro Ser Phe Gln Asp Asp Arg Ser His Trp 
465                 470                 475                 480 


Lys Ala Ser Ala Ser Gly Asp Asp Ser His Phe Asp Tyr Val His Asp 
                485                 490                 495     


Gln Asn Gln Lys Asn Leu Gly Gly Met Gln Ser Met Met Tyr Arg Asp 
            500                 505                 510         


Lys Leu Met Thr Ala Leu 
        515             


<210>  3588
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPB42__Homo_sapiens__NP_001107606

<400>  3588

Met Gly Gln Ala Leu Gly Ile Lys Ser Cys Asp Phe Gln Ala Ala Arg 
1               5                   10                  15      


Asn Asn Glu Glu His His Thr Lys Ala Leu Ser Ser Arg Arg Leu Phe 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Thr Ile Ile Leu Tyr Phe Arg Ala Pro 
        35                  40                  45              


Val Arg Ala Phe Leu Pro Ala Leu Lys Lys Val Ala Leu Thr Ala Gln 
    50                  55                  60                  


Thr Gly Glu Gln Pro Ser Lys Ile Asn Arg Thr Gln Ala Thr Phe Pro 
65                  70                  75                  80  


Ile Ser Ser Leu Gly Asp Arg Lys Trp Trp Ser Ala Val Val Glu Glu 
                85                  90                  95      


Arg Asp Ala Gln Ser Trp Thr Ile Ser Val Thr Thr Pro Ala Asp Ala 
            100                 105                 110         


Val Ile Gly His Tyr Ser Leu Leu Leu Gln Val Ser Gly Arg Lys Gln 
        115                 120                 125             


Leu Leu Leu Gly Gln Phe Thr Leu Leu Phe Asn Pro Trp Asn Arg Glu 
    130                 135                 140                 


Asp Ala Val Phe Leu Lys Asn Glu Ala Gln Arg Met Glu Tyr Leu Leu 
145                 150                 155                 160 


Asn Gln Asn Gly Leu Ile Tyr Leu Gly Thr Ala Asp Cys Ile Gln Ala 
                165                 170                 175     


Glu Ser Trp Asp Phe Gly Gln Phe Glu Gly Asp Val Ile Asp Leu Ser 
            180                 185                 190         


Leu Arg Leu Leu Ser Lys Asp Lys Gln Val Glu Lys Trp Ser Gln Pro 
        195                 200                 205             


Val His Val Ala Arg Val Leu Gly Ala Leu Leu His Phe Leu Lys Glu 
    210                 215                 220                 


Gln Arg Val Leu Pro Thr Pro Gln Thr Gln Ala Thr Gln Glu Gly Ala 
225                 230                 235                 240 


Leu Leu Asn Lys Arg Arg Gly Ser Val Pro Ile Leu Arg Gln Trp Leu 
                245                 250                 255     


Thr Gly Arg Gly Arg Pro Val Tyr Asp Gly Gln Ala Trp Val Leu Ala 
            260                 265                 270         


Ala Val Ala Cys Thr Val Leu Arg Cys Leu Gly Ile Pro Ala Arg Val 
        275                 280                 285             


Val Thr Thr Phe Ala Ser Ala Gln Gly Thr Gly Gly Arg Leu Leu Ile 
    290                 295                 300                 


Asp Glu Tyr Tyr Asn Glu Glu Gly Leu Gln Asn Gly Glu Gly Gln Arg 
305                 310                 315                 320 


Gly Arg Ile Trp Ile Phe Gln Thr Ser Thr Glu Cys Trp Met Thr Arg 
                325                 330                 335     


Pro Ala Leu Pro Gln Gly Tyr Asp Gly Trp Gln Ile Leu His Pro Ser 
            340                 345                 350         


Ala Pro Asn Gly Gly Gly Val Leu Gly Ser Cys Asp Leu Val Pro Val 
        355                 360                 365             


Arg Ala Val Lys Glu Gly Thr Leu Gly Leu Thr Pro Ala Val Ser Asp 
    370                 375                 380                 


Leu Phe Ala Ala Ile Asn Ala Ser Cys Val Val Trp Lys Cys Cys Glu 
385                 390                 395                 400 


Asp Gly Thr Leu Glu Leu Thr Asp Ser Asn Thr Lys Tyr Val Gly Asn 
                405                 410                 415     


Asn Ile Ser Thr Lys Gly Val Gly Ser Asp Arg Cys Glu Asp Ile Thr 
            420                 425                 430         


Gln Asn Tyr Lys Tyr Pro Glu Gly Ser Leu Gln Glu Lys Glu Val Leu 
        435                 440                 445             


Glu Arg Val Glu Lys Glu Lys Met Glu Arg Glu Lys Asp Asn Gly Ile 
    450                 455                 460                 


Arg Pro Pro Ser Leu Glu Thr Ala Ser Pro Leu Tyr Leu Leu Leu Lys 
465                 470                 475                 480 


Ala Pro Ser Ser Leu Pro Leu Arg Gly Asp Ala Gln Ile Ser Val Thr 
                485                 490                 495     


Leu Val Asn His Ser Glu Gln Glu Lys Ala Val Gln Leu Ala Ile Gly 
            500                 505                 510         


Val Gln Ala Val His Tyr Asn Gly Val Leu Ala Ala Lys Leu Trp Arg 
        515                 520                 525             


Lys Lys Leu His Leu Thr Leu Ser Ala Asn Leu Glu Lys Ile Ile Thr 
    530                 535                 540                 


Ile Gly Leu Phe Phe Ser Asn Phe Glu Arg Asn Pro Pro Glu Asn Thr 
545                 550                 555                 560 


Phe Leu Arg Leu Thr Ala Met Ala Thr His Ser Glu Ser Asn Leu Ser 
                565                 570                 575     


Cys Phe Ala Gln Glu Asp Ile Ala Ile Cys Arg Pro His Leu Ala Ile 
            580                 585                 590         


Lys Met Pro Glu Lys Ala Glu Gln Tyr Gln Pro Leu Thr Ala Ser Val 
        595                 600                 605             


Ser Leu Gln Asn Ser Leu Asp Ala Pro Met Glu Asp Cys Val Ile Ser 
    610                 615                 620                 


Ile Leu Gly Arg Gly Leu Ile His Arg Glu Arg Ser Tyr Arg Phe Arg 
625                 630                 635                 640 


Ser Val Trp Pro Glu Asn Thr Met Cys Ala Lys Phe Gln Phe Thr Pro 
                645                 650                 655     


Thr His Val Gly Leu Gln Arg Leu Thr Val Glu Val Asp Cys Asn Met 
            660                 665                 670         


Phe Gln Asn Leu Thr Asn Tyr Lys Ser Val Thr Val Val Ala Pro Glu 
        675                 680                 685             


Leu Ser Ala 
    690     


<210>  3589
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPC1__Homo_sapiens__NP_001258933

<400>  3589

Met Ser Lys Leu Ser Phe Arg Ala Arg Ala Leu Asp Ala Ser Lys Pro 
1               5                   10                  15      


Leu Pro Val Phe Arg Cys Glu Asp Leu Pro Asp Leu His Glu Tyr Ala 
            20                  25                  30          


Ser Ile Asn Arg Ala Val Pro Gln Met Pro Thr Gly Met Glu Lys Glu 
        35                  40                  45              


Glu Glu Ser Glu His His Leu Gln Arg Ala Ile Ser Ala Gln Gln Val 
    50                  55                  60                  


Tyr Gly Glu Lys Arg Asp Asn Met Val Ile Pro Val Pro Glu Ala Glu 
65                  70                  75                  80  


Ser Asn Ile Ala Tyr Tyr Glu Ser Ile Tyr Pro Gly Glu Phe Lys Met 
                85                  90                  95      


Pro Lys Gln Leu Ile His Ile Gln Pro Phe Ser Leu Asp Ala Glu Gln 
            100                 105                 110         


Pro Asp Tyr Asp Leu Asp Ser Glu Asp Glu Val Phe Val Asn Lys Leu 
        115                 120                 125             


Lys Lys Lys Met Asp Ile Cys Pro Leu Gln Phe Glu Glu Met Ile Asp 
    130                 135                 140                 


Arg Leu Glu Lys Gly Ser Gly Gln Gln Pro Val Ser Leu Gln Glu Ala 
145                 150                 155                 160 


Lys Leu Leu Leu Lys Glu Asp Asp Glu Leu Ile Arg Glu Val Tyr Glu 
                165                 170                 175     


Tyr Trp Ile Lys Lys Arg Lys Asn Cys Arg Gly Pro Ser Leu Ile Pro 
            180                 185                 190         


Ser Val Lys Gln Glu Lys Arg Asp Gly Ser Ser Thr Asn Asp Pro Tyr 
        195                 200                 205             


Val Ala Phe Arg Arg Arg Thr Glu Lys Met Gln Thr Arg Lys Asn Arg 
    210                 215                 220                 


Lys Asn Asp Glu Ala Ser Tyr Glu Lys Met Leu Lys Leu Arg Arg Asp 
225                 230                 235                 240 


Leu Ser Arg Ala Val Thr Ile Leu Glu Met Ile Lys Arg Arg Glu Lys 
                245                 250                 255     


Ser Lys Arg Glu Leu Leu His Leu Thr Leu Glu Ile Met Glu Lys Arg 
            260                 265                 270         


Tyr Asn Leu Gly Asp Tyr Asn Gly Glu Ile Met Ser Glu Val Met Ala 
        275                 280                 285             


Gln Arg Gln Pro Met Lys Pro Thr Tyr Ala Ile Pro Ile Ile Pro Ile 
    290                 295                 300                 


Thr Asn Ser Ser Gln Phe Lys His Gln Glu Ala Met Asp Val Lys Glu 
305                 310                 315                 320 


Phe Lys Val Asn Lys Gln Asp Lys Ala Asp Leu Ile Arg Pro Lys Arg 
                325                 330                 335     


Lys Tyr Glu Lys Lys Pro Lys Val Leu Pro Ser Ser Ala Ala Ala Thr 
            340                 345                 350         


Pro Gln Gln Thr Ser Pro Ala Ala Leu Pro Val Phe Asn Ala Lys Asp 
        355                 360                 365             


Leu Asn Gln Tyr Asp Phe Pro Ser Ser Asp Glu Glu Pro Leu Ser Gln 
    370                 375                 380                 


Val Leu Ser Gly Ser Ser Glu Ala Glu Glu Asp Asn Asp Pro Asp Gly 
385                 390                 395                 400 


Pro Phe Ala Phe Arg Arg Lys Ala Gly Cys Gln Tyr Tyr Ala Pro His 
                405                 410                 415     


Leu Asp Gln Thr Gly Asn Trp Pro Trp Thr Ser Pro Lys Asp Gly Gly 
            420                 425                 430         


Leu Gly Asp Val Arg Tyr Arg Tyr Cys Leu Thr Thr Leu Thr Val Pro 
        435                 440                 445             


Gln Arg Cys Ile Gly Phe Ala Arg Arg Arg Val Gly Arg Gly Gly Arg 
    450                 455                 460                 


Val Leu Leu Asp Arg Ala His Ser Asp Tyr Asp Ser Val Phe His His 
465                 470                 475                 480 


Leu Asp Leu Glu Met Leu Ser Ser Pro Gln His Ser Pro Val Asn Gln 
                485                 490                 495     


Phe Ala Asn Thr Ser Glu Thr Asn Thr Ser Asp Lys Ser Phe Ser Lys 
            500                 505                 510         


Asp Leu Ser Gln Ile Leu Val Asn Ile Lys Ser Cys Arg Trp Arg His 
        515                 520                 525             


Phe Arg Pro Arg Thr Pro Ser Leu His Asp Ser Asp Asn Asp Glu Leu 
    530                 535                 540                 


Ser Cys Arg Lys Leu Tyr Arg Ser Ile Asn Arg Thr Gly Thr Ala Gln 
545                 550                 555                 560 


Pro Gly Thr Gln Thr Cys Ser Thr Ser Thr Gln Ser Lys Ser Ser Ser 
                565                 570                 575     


Gly Ser Ala His Phe Ala Phe Thr Ala Glu Gln Tyr Gln Gln His Gln 
            580                 585                 590         


Gln Gln Leu Ala Leu Met Gln Lys Gln Gln Leu Ala Gln Ile Gln Gln 
        595                 600                 605             


Gln Gln Ala Asn Ser Asn Ser Ser Thr Asn Thr Ser Gln Gly Phe Val 
    610                 615                 620                 


Ser Lys Thr Leu Asp Ser Ala Ser Ala Gln Phe Ala Ala Ser Ala Leu 
625                 630                 635                 640 


Val Thr Ser Glu Gln Leu Met Gly Phe Lys Met Lys Asp Asp Val Val 
                645                 650                 655     


Leu Gly Ile Gly Val Asn Gly Val Leu Pro Ala Ser Gly Val Tyr Lys 
            660                 665                 670         


Gly Leu His Leu Ser Ser Thr Thr Pro Thr Ala Leu Val His Thr Ser 
        675                 680                 685             


Pro Ser Thr Ala Gly Ser Ala Leu Leu Gln Pro Ser Asn Ile Thr Gln 
    690                 695                 700                 


Thr Ser Ser Ser His Ser Ala Leu Ser His Gln Val Thr Ala Ala Asn 
705                 710                 715                 720 


Ser Ala Thr Thr Gln Val Leu Ile Gly Asn Asn Ile Arg Leu Thr Val 
                725                 730                 735     


Pro Ser Ser Val Ala Thr Val Asn Ser Ile Ala Pro Ile Asn Ala Arg 
            740                 745                 750         


His Ile Pro Arg Thr Leu Ser Ala Val Pro Ser Ser Ala Leu Lys Leu 
        755                 760                 765             


Ala Ala Ala Ala Asn Cys Gln Val Ser Lys Val Pro Ser Ser Ser Ser 
    770                 775                 780                 


Val Asp Ser Val Pro Arg Glu Asn His Glu Ser Glu Lys Pro Ala Leu 
785                 790                 795                 800 


Asn Asn Ile Ala Asp Asn Thr Val Ala Met Glu Val Thr 
                805                 810             


<210>  3590
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPC2__Homo_sapiens__NP_056445

<400>  3590

Met Ser Lys Leu Ser Phe Arg Ala Arg Ala Leu Asp Ala Ala Lys Pro 
1               5                   10                  15      


Leu Pro Ile Tyr Arg Gly Lys Asp Met Pro Asp Leu Asn Asp Cys Val 
            20                  25                  30          


Ser Ile Asn Arg Ala Val Pro Gln Met Pro Thr Gly Met Glu Lys Glu 
        35                  40                  45              


Glu Glu Ser Glu His His Leu Gln Arg Ala Ile Ser Ala Gln Gln Val 
    50                  55                  60                  


Phe Arg Glu Lys Lys Glu Ser Met Val Ile Pro Val Pro Glu Ala Glu 
65                  70                  75                  80  


Ser Asn Val Asn Tyr Tyr Asn Arg Leu Tyr Lys Gly Glu Phe Lys Gln 
                85                  90                  95      


Pro Lys Gln Phe Ile His Ile Gln Pro Phe Asn Leu Asp Asn Glu Gln 
            100                 105                 110         


Pro Asp Tyr Asp Met Asp Ser Glu Asp Glu Thr Leu Leu Asn Arg Leu 
        115                 120                 125             


Asn Arg Lys Met Glu Ile Lys Pro Leu Gln Phe Glu Ile Met Ile Asp 
    130                 135                 140                 


Arg Leu Glu Lys Ala Ser Ser Asn Gln Leu Val Thr Leu Gln Glu Ala 
145                 150                 155                 160 


Lys Leu Leu Leu Asn Glu Asp Asp Tyr Leu Ile Lys Ala Val Tyr Asp 
                165                 170                 175     


Tyr Trp Val Arg Lys Arg Lys Asn Cys Arg Gly Pro Ser Leu Ile Pro 
            180                 185                 190         


Gln Ile Lys Gln Glu Lys Arg Asp Gly Ser Thr Asn Asn Asp Pro Tyr 
        195                 200                 205             


Val Ala Phe Arg Arg Arg Thr Glu Lys Met Gln Thr Arg Lys Asn Arg 
    210                 215                 220                 


Lys Asn Asp Glu Ala Ser Tyr Glu Lys Met Leu Lys Leu Arg Arg Glu 
225                 230                 235                 240 


Phe Ser Arg Ala Ile Thr Ile Leu Glu Met Ile Lys Arg Arg Glu Lys 
                245                 250                 255     


Thr Lys Arg Glu Leu Leu His Leu Thr Leu Glu Val Val Glu Lys Arg 
            260                 265                 270         


Tyr His Leu Gly Asp Tyr Gly Gly Glu Ile Leu Asn Glu Val Lys Ile 
        275                 280                 285             


Ser Arg Ser Glu Lys Glu Leu Tyr Ala Thr Pro Ala Thr Leu His Asn 
    290                 295                 300                 


Gly Asn His His Lys Val Gln Glu Cys Lys Thr Lys His Pro His His 
305                 310                 315                 320 


Leu Ser Leu Lys Glu Glu Ala Ser Asp Val Val Arg Gln Lys Lys Lys 
                325                 330                 335     


Tyr Pro Lys Lys Pro Lys Ala Glu Ala Leu Ile Thr Ser Gln Gln Pro 
            340                 345                 350         


Thr Pro Glu Thr Leu Pro Val Ile Asn Lys Ser Asp Ile Lys Gln Tyr 
        355                 360                 365             


Asp Phe His Ser Ser Asp Glu Asp Glu Phe Pro Gln Val Leu Ser Pro 
    370                 375                 380                 


Val Ser Glu Pro Glu Glu Glu Asn Asp Pro Asp Gly Pro Cys Ala Phe 
385                 390                 395                 400 


Arg Arg Arg Ala Gly Cys Gln Tyr Tyr Ala Pro Arg Leu Asp Gln Ala 
                405                 410                 415     


Asn His Ser Cys Glu Asn Ser Glu Leu Ala Asp Leu Asp Lys Leu Arg 
            420                 425                 430         


Tyr Arg His Cys Leu Thr Thr Leu Thr Val Pro Arg Arg Cys Ile Gly 
        435                 440                 445             


Phe Ala Arg Arg Arg Ile Gly Arg Gly Gly Arg Val Ile Met Asp Arg 
    450                 455                 460                 


Ile Ser Thr Glu His Asp Pro Val Leu Lys Gln Ile Asp Pro Glu Met 
465                 470                 475                 480 


Leu Asn Ser Phe Ser Ser Ser Ser Gln Thr Ile Asp Phe Ser Ser Asn 
                485                 490                 495     


Phe Ser Arg Thr Asn Ala Ser Ser Lys His Cys Glu Asn Arg Leu Ser 
            500                 505                 510         


Leu Ser Glu Ile Leu Ser Asn Ile Arg Ser Cys Arg Leu Gln Cys Phe 
        515                 520                 525             


Gln Pro Arg Leu Leu Asn Leu Gln Asp Ser Asp Ser Glu Glu Cys Thr 
    530                 535                 540                 


Ser Arg Lys Pro Gly Gln Thr Val Asn Asn Lys Arg Val Ser Ala Ala 
545                 550                 555                 560 


Ser Val Ala Leu Leu Asn Thr Ser Lys Asn Gly Ile Ser Val Thr Gly 
                565                 570                 575     


Gly Ile Thr Glu Glu Gln Phe Gln Thr His Gln Gln Gln Leu Val Gln 
            580                 585                 590         


Met Gln Arg Gln Gln Leu Ala Gln Leu Gln Gln Lys Gln Gln Ser Gln 
        595                 600                 605             


His Ser Ser Gln Gln Thr His Pro Lys Ala Gln Gly Ser Ser Thr Ser 
    610                 615                 620                 


Asp Cys Met Ser Lys Thr Leu Asp Ser Ala Ser Ala His Phe Ala Ala 
625                 630                 635                 640 


Ser Ala Val Val Ser Ala Pro Val Pro Ser Arg Ser Glu Val Ala Lys 
                645                 650                 655     


Glu Gln Asn Thr Gly His Asn Asn Ile Asn Gly Val Val Gln Pro Ser 
            660                 665                 670         


Gly Thr Ser Lys Thr Leu Tyr Ser Thr Asn Met Ala Leu Ser Ser Ser 
        675                 680                 685             


Pro Gly Ile Ser Ala Val Gln Leu Val Arg Thr Val Gly His Thr Thr 
    690                 695                 700                 


Thr Asn His Leu Ile Pro Ala Leu Cys Thr Ser Ser Pro Gln Thr Leu 
705                 710                 715                 720 


Pro Met Asn Asn Ser Cys Leu Thr Asn Ala Val His Leu Asn Asn Val 
                725                 730                 735     


Ser Val Val Ser Pro Val Asn Val His Ile Asn Thr Arg Thr Ser Ala 
            740                 745                 750         


Pro Ser Pro Thr Ala Leu Lys Leu Ala Thr Val Ala Ala Ser Met Asp 
        755                 760                 765             


Arg Val Pro Lys Val Thr Pro Ser Ser Ala Ile Ser Ser Ile Ala Arg 
    770                 775                 780                 


Glu Asn His Glu Pro Glu Arg Leu Gly Leu Asn Gly Ile Ala Glu Thr 
785                 790                 795                 800 


Thr Val Ala Met Glu Val Thr 
                805         


<210>  3591
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPCAM__Homo_sapiens__NP_002345

<400>  3591

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  3592
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPDR1__Homo_sapiens__NP_060019

<400>  3592

Met Pro Gly Arg Ala Pro Leu Arg Thr Val Pro Gly Ala Leu Gly Ala 
1               5                   10                  15      


Trp Leu Leu Gly Gly Leu Trp Ala Trp Thr Leu Cys Gly Leu Cys Ser 
            20                  25                  30          


Leu Gly Ala Val Gly Ala Pro Arg Pro Cys Gln Ala Pro Gln Gln Trp 
        35                  40                  45              


Glu Gly Arg Gln Val Met Tyr Gln Gln Ser Ser Gly Arg Asn Ser Arg 
    50                  55                  60                  


Ala Leu Leu Ser Tyr Asp Gly Leu Asn Gln Arg Val Arg Val Leu Asp 
65                  70                  75                  80  


Glu Arg Lys Ala Leu Ile Pro Cys Lys Arg Leu Phe Glu Tyr Ile Leu 
                85                  90                  95      


Leu Tyr Lys Asp Gly Val Met Phe Gln Ile Asp Gln Ala Thr Lys Gln 
            100                 105                 110         


Cys Ser Lys Met Thr Leu Thr Gln Pro Trp Asp Pro Leu Asp Ile Pro 
        115                 120                 125             


Gln Asn Ser Thr Phe Glu Asp Gln Tyr Ser Ile Gly Gly Pro Gln Glu 
    130                 135                 140                 


Gln Ile Thr Val Gln Glu Trp Ser Asp Arg Lys Ser Ala Arg Ser Tyr 
145                 150                 155                 160 


Glu Thr Trp Ile Gly Ile Tyr Thr Val Lys Asp Cys Tyr Pro Val Gln 
                165                 170                 175     


Glu Thr Phe Thr Ile Asn Tyr Ser Val Ile Leu Ser Thr Arg Phe Phe 
            180                 185                 190         


Asp Ile Gln Leu Gly Ile Lys Asp Pro Ser Val Phe Thr Pro Pro Ser 
        195                 200                 205             


Thr Cys Gln Met Ala Gln Leu Glu Lys Met Ser Glu Asp Cys Ser Trp 
    210                 215                 220                 


<210>  3593
<211>  2579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPG5__Homo_sapiens__NP_066015

<400>  3593

Met Ala Glu Ala Val Lys Pro Gln Arg Arg Ala Lys Ala Lys Ala Ser 
1               5                   10                  15      


Arg Thr Lys Thr Lys Glu Lys Lys Lys Tyr Glu Thr Pro Gln Arg Glu 
            20                  25                  30          


Glu Ser Ser Glu Val Ser Leu Pro Lys Thr Ser Arg Glu Gln Glu Ile 
        35                  40                  45              


Pro Ser Leu Ala Cys Glu Phe Lys Gly Asp His Leu Lys Val Val Thr 
    50                  55                  60                  


Asp Ser Gln Leu Gln Asp Asp Ala Ser Gly Gln Asn Glu Ser Glu Met 
65                  70                  75                  80  


Phe Asp Val Pro Leu Thr Ser Leu Thr Ile Ser Asn Glu Glu Ser Leu 
                85                  90                  95      


Thr Cys Asn Thr Glu Pro Pro Lys Glu Gly Gly Glu Ala Arg Pro Cys 
            100                 105                 110         


Val Gly Asp Ser Ala Val Thr Pro Lys Val His Pro Gly Asp Asn Val 
        115                 120                 125             


Gly Thr Lys Val Glu Thr Pro Lys Asn Phe Thr Glu Val Glu Glu Asn 
    130                 135                 140                 


Met Ser Val Gln Gly Gly Leu Ser Glu Ser Ala Pro Gln Ser Asn Phe 
145                 150                 155                 160 


Ser Tyr Thr Gln Pro Ala Met Glu Asn Ile Gln Val Arg Glu Thr Gln 
                165                 170                 175     


Asn Ser Lys Glu Asp Lys Gln Gly Leu Val Cys Ser Ser Glu Val Pro 
            180                 185                 190         


Gln Asn Val Gly Leu Gln Ser Ser Cys Pro Ala Lys His Gly Phe Gln 
        195                 200                 205             


Thr Pro Arg Val Lys Lys Leu Tyr Pro Gln Leu Pro Ala Glu Ile Ala 
    210                 215                 220                 


Gly Glu Ala Pro Ala Leu Val Ala Val Lys Pro Leu Leu Arg Ser Glu 
225                 230                 235                 240 


Arg Leu Tyr Pro Glu Leu Pro Ser Gln Leu Glu Leu Val Pro Phe Thr 
                245                 250                 255     


Lys Glu Gln Leu Lys Ile Leu Glu Pro Gly Ser Trp Leu Glu Asn Val 
            260                 265                 270         


Glu Ser Tyr Leu Glu Glu Phe Asp Ser Met Ala His Gln Asp Arg His 
        275                 280                 285             


Glu Phe Tyr Glu Leu Leu Leu Asn Tyr Ser Arg Cys Arg Lys Gln Leu 
    290                 295                 300                 


Leu Leu Ala Glu Ala Glu Leu Leu Thr Leu Thr Ser Asp Cys Gln Asn 
305                 310                 315                 320 


Ala Lys Ser Arg Leu Trp Gln Phe Lys Glu Glu Gln Met Ser Val Gln 
                325                 330                 335     


Gly Ile Cys Ala Asp Gln Val Lys Val Phe Ser Tyr His Arg Tyr Gln 
            340                 345                 350         


Arg Val Glu Met Asn Glu Asn Ala Leu Val Glu Leu Lys Lys Leu Phe 
        355                 360                 365             


Asp Ala Lys Ser Glu His Leu His Gln Thr Leu Ala Leu His Ser Tyr 
    370                 375                 380                 


Thr Ser Val Leu Ser Arg Leu Gln Val Glu Ser Tyr Ile Tyr Ala Leu 
385                 390                 395                 400 


Leu Ser Ser Ser Ala Val Leu Arg Ser Ser Ala Ile His Gln Gln Gly 
                405                 410                 415     


Arg Ala Ser Lys Gln Thr Glu Ser Ile Pro Ser Asp Leu Cys Gln Leu 
            420                 425                 430         


Lys Glu Cys Ile Ser Val Leu Phe Met Phe Thr Arg Arg Val Asn Glu 
        435                 440                 445             


Asp Thr Gln Phe His Asp Asp Ile Leu Leu Trp Leu Gln Lys Leu Val 
    450                 455                 460                 


Ser Val Leu Gln Arg Val Gly Cys Pro Gly Asp His Leu Phe Leu Leu 
465                 470                 475                 480 


Asn His Ile Leu Arg Cys Pro Ala Gly Val Ser Lys Trp Ala Val Pro 
                485                 490                 495     


Phe Ile Gln Ile Lys Val Leu His Asn Pro Ser Gly Val Phe His Phe 
            500                 505                 510         


Met Gln Ser Leu Ala Leu Leu Met Ser Pro Val Lys Asn Arg Ala Glu 
        515                 520                 525             


Phe Met Cys His Met Lys Pro Ser Glu Arg Lys Pro Ser Ser Ser Gly 
    530                 535                 540                 


Pro Gly Ser Gly Thr Trp Thr Leu Val Asp Glu Gly Gly Glu Glu Asp 
545                 550                 555                 560 


Glu Asp Pro Glu Thr Ser Trp Ile Leu Leu Asn Glu Asp Asp Leu Val 
                565                 570                 575     


Thr Ile Leu Ala Gln Phe Pro Phe His Glu Leu Phe Gln His Leu Leu 
            580                 585                 590         


Gly Phe Lys Ala Lys Gly Asp Tyr Leu Pro Glu Thr Thr Arg Pro Gln 
        595                 600                 605             


Glu Met Met Lys Ile Phe Ala Phe Ala Asn Ser Leu Val Glu Leu Leu 
    610                 615                 620                 


Ala Val Gly Leu Glu Thr Phe Asn Arg Ala Arg Tyr Arg Gln Phe Val 
625                 630                 635                 640 


Lys Arg Ile Gly Tyr Met Ile Arg Met Thr Leu Gly Tyr Val Ser Asp 
                645                 650                 655     


His Trp Ala Gln Tyr Val Ser His Asn Gln Gly Ser Gly Leu Ala Gln 
            660                 665                 670         


Gln Pro Tyr Ser Met Glu Lys Leu Gln Val Glu Phe Asp Glu Leu Phe 
        675                 680                 685             


Leu Arg Ala Val Leu His Val Leu Lys Ala Lys Arg Leu Gly Ile Trp 
    690                 695                 700                 


Leu Phe Met Ser Glu Met Pro Phe Gly Thr Leu Ser Val Gln Met Leu 
705                 710                 715                 720 


Trp Lys Leu Phe Tyr Leu Met His Gln Val Glu Ser Glu Asn Leu Gln 
                725                 730                 735     


Gln Leu Ser Ser Ser Leu Gln Pro Ala Gln Cys Lys Gln Gln Leu Gln 
            740                 745                 750         


Asp Pro Glu His Phe Thr Asn Phe Glu Lys Cys Leu Ser Ser Met Asn 
        755                 760                 765             


Ser Ser Glu Glu Ile Cys Leu Leu Thr Thr Phe Ala Gln Met Ala Gln 
    770                 775                 780                 


Ala Arg Arg Thr Asn Val Asp Glu Asp Phe Ile Lys Ile Ile Val Leu 
785                 790                 795                 800 


Glu Ile Tyr Glu Val Ser Tyr Val Thr Leu Ser Thr Arg Glu Thr Phe 
                805                 810                 815     


Ser Lys Val Gly Arg Glu Leu Leu Gly Thr Ile Thr Ala Val His Pro 
            820                 825                 830         


Glu Ile Ile Ser Val Leu Leu Asp Arg Val Gln Glu Thr Ile Asp Gln 
        835                 840                 845             


Val Gly Met Val Ser Leu Tyr Leu Phe Lys Glu Leu Pro Leu Tyr Leu 
    850                 855                 860                 


Trp Gln Pro Ser Ala Ser Glu Ile Ala Val Ile Arg Asp Trp Leu Leu 
865                 870                 875                 880 


Asn Tyr Asn Leu Thr Val Val Lys Asn Lys Leu Ala Cys Val Ile Leu 
                885                 890                 895     


Glu Gly Leu Asn Trp Gly Phe Ala Lys Gln Ala Thr Leu His Leu Asp 
            900                 905                 910         


Gln Ala Val His Ala Glu Val Ala Leu Met Val Leu Glu Ala Tyr Gln 
        915                 920                 925             


Lys Tyr Leu Ala Gln Lys Pro Tyr Ala Gly Ile Leu Ser Glu Ser Met 
    930                 935                 940                 


Lys Gln Val Ser Tyr Leu Ala Ser Ile Val Arg Tyr Gly Glu Thr Pro 
945                 950                 955                 960 


Glu Thr Ser Phe Asn Gln Trp Ala Trp Asn Leu Ile Leu Arg Leu Lys 
                965                 970                 975     


Leu His Lys Asn Asp Tyr Gly Ile Gln Pro Asn Cys Pro Ala Val Pro 
            980                 985                 990         


Phe Ser Val Thr Val Pro Asp Met  Thr Glu Ser Pro Thr  Phe His Pro 
        995                 1000                 1005             


Leu Leu  Lys Ala Val Lys Ala  Gly Met Pro Ile Gly  Cys Tyr Leu 
    1010                 1015                 1020             


Ala Leu  Ser Met Thr Ala Val  Gly His Ser Ile Glu  Lys Phe Cys 
    1025                 1030                 1035             


Ala Glu  Gly Ile Pro Leu Leu  Gly Ile Leu Val Gln  Ser Arg His 
    1040                 1045                 1050             


Leu Arg  Thr Val Val His Val  Leu Asp Lys Ile Leu  Pro Leu Phe 
    1055                 1060                 1065             


Tyr Pro  Cys Gln Tyr Tyr Leu  Leu Lys Asn Glu Gln  Phe Leu Ser 
    1070                 1075                 1080             


His Leu  Leu Leu Phe Leu His  Leu Asp Ser Gly Val  Pro Gln Gly 
    1085                 1090                 1095             


Val Thr  Gln Gln Val Thr His  Lys Val Ala Gln His  Leu Thr Gly 
    1100                 1105                 1110             


Ala Ser  His Gly Asp Asn Val  Lys Leu Leu Asn Ser  Met Ile Gln 
    1115                 1120                 1125             


Ala His  Ile Ser Val Ser Thr  Gln Pro Asn Glu Val  Gly Pro Val 
    1130                 1135                 1140             


Ala Val  Leu Glu Phe Trp Val  Gln Ala Leu Ile Ser  Gln His Leu 
    1145                 1150                 1155             


Trp Tyr  Arg Glu Gln Pro Ile  Leu Phe Leu Met Asp  His Leu Cys 
    1160                 1165                 1170             


Lys Ala  Ala Phe Gln Leu Met  Gln Glu Asp Cys Ile  Gln Lys Leu 
    1175                 1180                 1185             


Leu Tyr  Gln Gln His Lys Asn  Ala Leu Gly Tyr His  Cys Asp Arg 
    1190                 1195                 1200             


Ser Leu  Leu Ser Ser Leu Val  Ser Trp Ile Val Ala  Gly Asn Ile 
    1205                 1210                 1215             


Thr Pro  Ser Phe Val Glu Gly  Leu Ala Thr Pro Thr  Gln Val Trp 
    1220                 1225                 1230             


Phe Ala  Trp Thr Val Leu Asn  Met Glu Ser Ile Phe  Glu Glu Asp 
    1235                 1240                 1245             


Ser Gln  Leu Arg Arg Val Ile  Glu Gly Glu Leu Val  Ile Asn Ser 
    1250                 1255                 1260             


Ala Phe  Thr Pro Asp Gln Ala  Leu Lys Lys Ala Gln  Thr Gln Leu 
    1265                 1270                 1275             


Lys Leu  Pro Ile Val Pro Ser  Leu Gln Arg Leu Leu  Ile Tyr Arg 
    1280                 1285                 1290             


Trp Ala  His Gln Ala Leu Val  Thr Pro Ser Asp His  Pro Leu Leu 
    1295                 1300                 1305             


Pro Leu  Ile Trp Gln Lys Phe  Phe Leu Leu Tyr Leu  His Arg Pro 
    1310                 1315                 1320             


Gly Pro  Gln Tyr Gly Leu Pro  Ile Asp Gly Cys Ile  Gly Arg Arg 
    1325                 1330                 1335             


Phe Phe  Gln Ser Pro Ala His  Ile Asn Leu Leu Lys  Glu Met Lys 
    1340                 1345                 1350             


Arg Arg  Leu Thr Glu Val Ala  Asp Phe His His Ala  Ala Ser Lys 
    1355                 1360                 1365             


Ala Leu  Arg Val Pro Ala Glu  Gly Ser Glu Gly Leu  Pro Glu Ser 
    1370                 1375                 1380             


His Ser  Gly Thr Pro Gly Tyr  Leu Thr Ser Pro Glu  Leu His Lys 
    1385                 1390                 1395             


Glu Leu  Val Arg Leu Phe Asn  Val Tyr Ile Leu Trp  Leu Glu Asp 
    1400                 1405                 1410             


Glu Asn  Phe Gln Lys Gly Asp  Thr Tyr Ile Pro Ser  Leu Pro Lys 
    1415                 1420                 1425             


His Tyr  Asp Ile His Arg Leu  Ala Lys Val Met Gln  Asn Gln Gln 
    1430                 1435                 1440             


Asp Leu  Trp Met Glu Tyr Leu  Asn Met Glu Arg Ile  Tyr His Glu 
    1445                 1450                 1455             


Phe Gln  Glu Thr Val Gly Leu  Trp Thr Gln Ala Lys  Leu Glu Ser 
    1460                 1465                 1470             


His Ser  Thr Pro Cys Ser Leu  Ser Val Gln Leu Asp  Phe Thr Asp 
    1475                 1480                 1485             


Pro Leu  Leu Ala Lys Glu Arg  Val Leu Ser Asn Leu  Arg Lys His 
    1490                 1495                 1500             


Glu Ala  Pro Gln Pro Pro Leu  Ala Leu His Pro Thr  Lys Pro Pro 
    1505                 1510                 1515             


Val Pro  Val Ile Ser Ser Ala  Val Leu Leu Ser Gln  Lys Asp Ala 
    1520                 1525                 1530             


Thr Gln  Leu Val Cys Thr Asp  Leu Asn Leu Leu Gln  Gln Gln Ala 
    1535                 1540                 1545             


Arg Thr  Ala Ala Leu Arg Glu  Ser Gln Gln Val Ala  Leu Asp Gly 
    1550                 1555                 1560             


Glu Leu  Leu Asp Thr Met Pro  Lys Gln Tyr Val Asn  Arg Glu Glu 
    1565                 1570                 1575             


Gln Thr  Thr Leu His Leu Glu  Cys Arg Gly Ser Ser  Gly Lys Lys 
    1580                 1585                 1590             


Cys Gln  Gly Ala Ala Val Val  Thr Val Gln Phe Glu  Gly Met His 
    1595                 1600                 1605             


Lys Asn  Glu Ala Ile Ser Gln  Gln Leu His Val Leu  Arg Lys Glu 
    1610                 1615                 1620             


Val Lys  Gln Leu Gln Ala Glu  Ala Ala Lys Pro Pro  Ser Leu Asn 
    1625                 1630                 1635             


Ile Val  Glu Ala Ala Val His  Ala Glu Asn Leu Ile  Thr Ala Leu 
    1640                 1645                 1650             


Val Asn  Ala Tyr Lys Leu Gln  Pro Thr Pro Gly Ile  Gln Lys Val 
    1655                 1660                 1665             


Gly Ile  Ser Leu Phe Phe Thr  Ile Val Asp Tyr Val  Ser Asp Glu 
    1670                 1675                 1680             


Thr Gln  Arg His Pro Pro Thr  Arg Gln Phe Phe Thr  Ser Cys Ile 
    1685                 1690                 1695             


Glu Ile  Leu Gly Gln Val Phe  Ile Ser Gly Ile Lys  Ser Glu Cys 
    1700                 1705                 1710             


Arg Lys  Val Leu Glu Thr Ile  Leu Lys Asn Ser Arg  Leu Cys Ser 
    1715                 1720                 1725             


Leu Leu  Ser Pro Phe Phe Thr  Pro Asn Ala Ala Pro  Ala Glu Phe 
    1730                 1735                 1740             


Ile Gln  Leu Tyr Glu Gln Val  Val Lys Phe Leu Ser  Glu Asp Asn 
    1745                 1750                 1755             


Ser Asp  Met Ile Phe Met Leu  Leu Thr Lys Phe Asp  Leu Lys Gln 
    1760                 1765                 1770             


Trp Leu  Ser Ala Thr Lys Pro  Pro Leu Ser Asp Arg  Thr Arg Leu 
    1775                 1780                 1785             


Leu Glu  Ser Ile His Leu Ala  Leu Thr Ala Trp Gly  Leu Glu Pro 
    1790                 1795                 1800             


Asp Glu  Asp Ile Leu Met Pro  Phe Asn Leu Phe Cys  Lys His Trp 
    1805                 1810                 1815             


Thr Tyr  Leu Leu Leu Tyr Gln  Phe Pro Asp Gln Tyr  Ser Asp Ile 
    1820                 1825                 1830             


Leu Arg  Leu Leu Met Gln Ser  Ser Ala Glu Gln Leu  Leu Ser Pro 
    1835                 1840                 1845             


Glu Cys  Trp Lys Ala Thr Leu  Arg Ala Leu Gly Cys  Cys Ala Pro 
    1850                 1855                 1860             


Ser Cys  Gln Gln Gly Ala Ala  Ser Thr Glu Gly Ala  Val Leu Pro 
    1865                 1870                 1875             


Ser Ser  Ser Asp Ala Leu Leu  Ser Asp Lys Gln Val  Met Glu Thr 
    1880                 1885                 1890             


Ile Gln  Trp Leu Ser Asp Phe  Phe Tyr Lys Leu Arg  Leu Ser Lys 
    1895                 1900                 1905             


Met Asp  Phe Lys Ser Phe Gly  Leu Phe Ser Lys Trp  Ser Pro Tyr 
    1910                 1915                 1920             


Met Ala  Asp Val Lys Thr Phe  Leu Gly Tyr Leu Val  Lys Arg Leu 
    1925                 1930                 1935             


Ile Asp  Leu Glu Met Thr Cys  Leu Ala Gln Asp Pro  Thr Ala Ser 
    1940                 1945                 1950             


Arg Lys  Thr Val Leu Lys Ser  Leu His Ser Val Ile  Ile Gln Leu 
    1955                 1960                 1965             


Phe Lys  Pro Trp Ile Leu Val  Leu Glu Asp Asn Glu  Ser Ser Gln 
    1970                 1975                 1980             


Gln Arg  His Tyr Pro Trp Leu  Glu Ser Asp Thr Val  Val Ala Ser 
    1985                 1990                 1995             


Ser Ile  Val Gln Leu Phe Thr  Asp Cys Ile Asp Ser  Leu His Glu 
    2000                 2005                 2010             


Ser Phe  Lys Asp Lys Leu Leu  Pro Gly Asp Ala Gly  Ala Leu Trp 
    2015                 2020                 2025             


Leu His  Leu Met His Tyr Cys  Glu Ala Cys Thr Ala  Pro Lys Met 
    2030                 2035                 2040             


Pro Glu  Phe Ile Leu Tyr Ala  Phe His Ser Thr Tyr  Arg Lys Leu 
    2045                 2050                 2055             


Pro Trp  Lys Asp Leu His Pro  Asp Gln Met Leu Met  Glu Ala Phe 
    2060                 2065                 2070             


Phe Lys  Val Glu Arg Gly Ser  Pro Lys Ser Cys Phe  Leu Phe Leu 
    2075                 2080                 2085             


Gly Ser  Val Leu Cys Glu Val  Asn Trp Val Ser Val  Leu Ser Asp 
    2090                 2095                 2100             


Ala Trp  Asn Ser Ser Pro His  Pro Glu Thr Arg Ser  Met Ile Val 
    2105                 2110                 2115             


Cys Leu  Leu Phe Met Met Ile  Leu Leu Ala Lys Glu  Val Gln Leu 
    2120                 2125                 2130             


Val Asp  Gln Thr Asp Ser Pro  Leu Leu Ser Leu Leu  Gly Gln Thr 
    2135                 2140                 2145             


Ser Ser  Leu Ser Trp His Leu  Val Asp Ile Val Ser  Tyr Gln Ser 
    2150                 2155                 2160             


Val Leu  Ser Tyr Phe Ser Ser  His Tyr Pro Pro Ser  Ile Ile Leu 
    2165                 2170                 2175             


Ala Lys  Glu Ser Tyr Ala Glu  Leu Ile Met Lys Leu  Leu Lys Val 
    2180                 2185                 2190             


Ser Ala  Gly Leu Ser Ile Pro  Thr Asp Ser Gln Lys  His Leu Asp 
    2195                 2200                 2205             


Ala Val  Pro Lys Cys Gln Ala  Phe Thr His Gln Met  Val Gln Phe 
    2210                 2215                 2220             


Leu Ser  Thr Leu Glu Gln Asn  Gly Lys Ile Thr Leu  Ala Val Leu 
    2225                 2230                 2235             


Glu Gln  Glu Met Ser Lys Leu  Leu Asp Asp Ile Ile  Val Phe Asn 
    2240                 2245                 2250             


Pro Pro  Asp Met Asp Ser Gln  Thr Arg His Met Ala  Leu Ser Ser 
    2255                 2260                 2265             


Leu Phe  Met Glu Val Leu Met  Met Met Asn Asn Ala  Thr Ile Pro 
    2270                 2275                 2280             


Thr Ala  Glu Phe Leu Arg Gly  Ser Ile Arg Thr Trp  Ile Gly Gln 
    2285                 2290                 2295             


Lys Met  His Gly Leu Val Val  Leu Pro Leu Leu Thr  Ala Ala Cys 
    2300                 2305                 2310             


Gln Ser  Leu Ala Ser Val Arg  His Met Ala Glu Thr  Thr Glu Ala 
    2315                 2320                 2325             


Cys Ile  Thr Ala Tyr Phe Lys  Glu Ser Pro Leu Asn  Gln Asn Ser 
    2330                 2335                 2340             


Gly Trp  Gly Pro Ile Leu Val  Ser Leu Gln Val Pro  Glu Leu Thr 
    2345                 2350                 2355             


Met Glu  Glu Phe Leu Gln Glu  Cys Leu Thr Leu Gly  Ser Tyr Leu 
    2360                 2365                 2370             


Thr Leu  Tyr Val Tyr Leu Leu  Gln Cys Leu Asn Ser  Glu Gln Thr 
    2375                 2380                 2385             


Leu Arg  Asn Glu Met Lys Val  Leu Leu Ile Leu Ser  Lys Trp Leu 
    2390                 2395                 2400             


Glu Gln  Val Tyr Pro Ser Ser  Val Glu Glu Glu Ala  Lys Leu Phe 
    2405                 2410                 2415             


Leu Trp  Trp His Gln Val Leu  Gln Leu Ser Leu Ile  Gln Thr Glu 
    2420                 2425                 2430             


Gln Asn  Asp Ser Val Leu Thr  Glu Ser Val Ile Arg  Ile Leu Leu 
    2435                 2440                 2445             


Leu Val  Gln Ser Arg Gln Asn  Leu Val Ala Glu Glu  Arg Leu Ser 
    2450                 2455                 2460             


Ser Gly  Ile Leu Gly Ala Ile  Gly Phe Gly Arg Lys  Ser Pro Leu 
    2465                 2470                 2475             


Ser Asn  Arg Phe Arg Val Val  Ala Arg Ser Met Ala  Ala Phe Leu 
    2480                 2485                 2490             


Ser Val  Gln Val Pro Met Glu  Asp Gln Ile Arg Leu  Arg Pro Gly 
    2495                 2500                 2505             


Ser Glu  Leu His Leu Thr Pro  Lys Ala Gln Gln Ala  Leu Asn Ala 
    2510                 2515                 2520             


Leu Glu  Ser Met Ala Ser Ser  Lys Gln Tyr Val Glu  Tyr Gln Asp 
    2525                 2530                 2535             


Gln Ile  Leu Gln Ala Thr Gln  Phe Ile Arg His Pro  Gly His Cys 
    2540                 2545                 2550             


Leu Gln  Asp Gly Lys Ser Phe  Leu Ala Leu Leu Val  Asn Cys Leu 
    2555                 2560                 2565             


Tyr Pro  Glu Val His Tyr Leu  Asp His Ile Arg 
    2570                 2575                 


<210>  3594
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPGN__Homo_sapiens__NP_001257918

<400>  3594

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                  40                  45              


Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                  55                  60                  


Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                  70                  75                  80  


Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Glu 
                85                  90                  95      


His Leu Thr Leu Thr Ser Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile 
            100                 105                 110         


Ala Ile Gly Ile Gly Val Gly Leu Leu Leu Ser Gly Phe Leu Val Ile 
        115                 120                 125             


Phe Tyr Cys Tyr Ile Arg Lys Arg Cys Leu Lys Leu Lys Ser Pro Tyr 
    130                 135                 140                 


Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
145                 150                 


<210>  3595
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHA1__Homo_sapiens__NP_005223

<400>  3595

Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys 
1               5                   10                  15      


Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp 
            20                  25                  30          


Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys 
        35                  40                  45              


Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr 
    50                  55                  60                  


Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp 
65                  70                  75                  80  


Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His 
                85                  90                  95      


Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly 
            100                 105                 110         


Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu 
        115                 120                 125             


Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys 
    130                 135                 140                 


Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Val 
145                 150                 155                 160 


Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu 
                165                 170                 175     


Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu 
        195                 200                 205             


Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu 
    210                 215                 220                 


Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu 
                245                 250                 255     


Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly 
            260                 265                 270         


Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp 
        275                 280                 285             


Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu 
    290                 295                 300                 


Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala 
305                 310                 315                 320 


Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro 
                325                 330                 335     


Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp 
            340                 345                 350         


Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val 
        355                 360                 365             


Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln 
    370                 375                 380                 


Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr 
385                 390                 395                 400 


Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr 
                405                 410                 415     


Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly 
            420                 425                 430         


His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu 
        435                 440                 445             


Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu 
    450                 455                 460                 


Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr 
465                 470                 475                 480 


Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val 
                485                 490                 495     


Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr 
            500                 505                 510         


Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser 
        515                 520                 525             


Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr 
    530                 535                 540                 


Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala 
545                 550                 555                 560 


Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln 
                565                 570                 575     


Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp 
            580                 585                 590         


Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro 
        595                 600                 605             


Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu 
    610                 615                 620                 


Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg 
625                 630                 635                 640 


Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys 
                645                 650                 655     


Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg 
            660                 665                 670         


Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu 
        675                 680                 685             


Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe 
    690                 695                 700                 


Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln 
705                 710                 715                 720 


Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly 
                725                 730                 735     


Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala 
            740                 745                 750         


Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe 
        755                 760                 765             


Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His 
785                 790                 795                 800 


Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn 
            820                 825                 830         


Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala 
    850                 855                 860                 


Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu 
865                 870                 875                 880 


Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe 
                885                 890                 895     


Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly 
            900                 905                 910         


Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys 
        915                 920                 925             


Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys 
    930                 935                 940                 


Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu 
945                 950                 955                 960 


Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp 
                965                 970                 975     


<210>  3596
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHA3__Homo_sapiens__NP_005224

<400>  3596

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys 
        915                 920                 925             


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala 
    930                 935                 940                 


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly 
945                 950                 955                 960 


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser 
                965                 970                 975     


Lys Asn Gly Pro Val Pro Val 
            980             


<210>  3597
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHA4__Homo_sapiens__NP_001291465

<400>  3597

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  3598
<211>  1038
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHA5__Homo_sapiens__NP_001268694

<400>  3598

Met Arg Gly Ser Gly Pro Arg Gly Ala Gly Arg Arg Arg Pro Pro Ser 
1               5                   10                  15      


Gly Gly Gly Asp Thr Pro Ile Thr Pro Ala Ser Leu Ala Gly Cys Tyr 
            20                  25                  30          


Ser Ala Pro Arg Arg Ala Pro Leu Trp Thr Cys Leu Leu Leu Cys Ala 
        35                  40                  45              


Ala Leu Arg Thr Leu Leu Ala Ser Pro Ser Asn Glu Val Asn Leu Leu 
    50                  55                  60                  


Asp Ser Arg Thr Val Met Gly Asp Leu Gly Trp Ile Ala Phe Pro Lys 
65                  70                  75                  80  


Asn Gly Trp Glu Glu Ile Gly Glu Val Asp Glu Asn Tyr Ala Pro Ile 
                85                  90                  95      


His Thr Tyr Gln Val Cys Lys Val Met Glu Gln Asn Gln Asn Asn Trp 
            100                 105                 110         


Leu Leu Thr Ser Trp Ile Ser Asn Glu Gly Ala Ser Arg Ile Phe Ile 
        115                 120                 125             


Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Gly Leu 
    130                 135                 140                 


Gly Thr Cys Lys Glu Thr Phe Asn Met Tyr Tyr Phe Glu Ser Asp Asp 
145                 150                 155                 160 


Gln Asn Gly Arg Asn Ile Lys Glu Asn Gln Tyr Ile Lys Ile Asp Thr 
                165                 170                 175     


Ile Ala Ala Asp Glu Ser Phe Thr Glu Leu Asp Leu Gly Asp Arg Val 
            180                 185                 190         


Met Lys Leu Asn Thr Glu Val Arg Asp Val Gly Pro Leu Ser Lys Lys 
        195                 200                 205             


Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val 
    210                 215                 220                 


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Ser Val Val Arg His Leu 
225                 230                 235                 240 


Ala Val Phe Pro Asp Thr Ile Thr Gly Ala Asp Ser Ser Gln Leu Leu 
                245                 250                 255     


Glu Val Ser Gly Ser Cys Val Asn His Ser Val Thr Asp Glu Pro Pro 
            260                 265                 270         


Lys Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
        275                 280                 285             


Cys Met Cys Lys Ala Gly Tyr Glu Glu Lys Asn Gly Thr Cys Gln Val 
    290                 295                 300                 


Cys Arg Pro Gly Phe Phe Lys Ala Ser Pro His Ile Gln Ser Cys Gly 
305                 310                 315                 320 


Lys Cys Pro Pro His Ser Tyr Thr His Glu Glu Ala Ser Thr Ser Cys 
                325                 330                 335     


Val Cys Glu Lys Asp Tyr Phe Arg Arg Glu Ser Asp Pro Pro Thr Met 
            340                 345                 350         


Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Ala Ile Ser Asn Val 
        355                 360                 365             


Asn Glu Thr Ser Val Phe Leu Glu Trp Ile Pro Pro Ala Asp Thr Gly 
    370                 375                 380                 


Gly Arg Lys Asp Val Ser Tyr Tyr Ile Ala Cys Lys Lys Cys Asn Ser 
385                 390                 395                 400 


His Ala Gly Val Cys Glu Glu Cys Gly Gly His Val Arg Tyr Leu Pro 
                405                 410                 415     


Arg Gln Ser Gly Leu Lys Asn Thr Ser Val Met Met Val Asp Leu Leu 
            420                 425                 430         


Ala His Thr Asn Tyr Thr Phe Glu Ile Glu Ala Val Asn Gly Val Ser 
        435                 440                 445             


Asp Leu Ser Pro Gly Ala Arg Gln Tyr Val Ser Val Asn Val Thr Thr 
    450                 455                 460                 


Asn Gln Ala Ala Pro Ser Pro Val Thr Asn Val Lys Lys Gly Lys Ile 
465                 470                 475                 480 


Ala Lys Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Asp Arg Pro Asn 
                485                 490                 495     


Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Phe Glu Lys Asp Gln Glu 
            500                 505                 510         


Thr Ser Tyr Thr Ile Ile Lys Ser Lys Glu Thr Thr Ile Thr Ala Glu 
        515                 520                 525             


Gly Leu Lys Pro Ala Ser Val Tyr Val Phe Gln Ile Arg Ala Arg Thr 
    530                 535                 540                 


Ala Ala Gly Tyr Gly Val Phe Ser Arg Arg Phe Glu Phe Glu Thr Thr 
545                 550                 555                 560 


Pro Val Ser Val Ala Ala Ser Ser Asp Gln Ser Gln Ile Pro Val Ile 
                565                 570                 575     


Ala Val Ser Val Thr Val Gly Val Ile Leu Leu Ala Val Val Ile Gly 
            580                 585                 590         


Val Leu Leu Ser Gly Ser Cys Cys Glu Cys Gly Cys Gly Arg Ala Ser 
        595                 600                 605             


Ser Leu Cys Ala Val Ala His Pro Ser Leu Ile Trp Arg Cys Gly Tyr 
    610                 615                 620                 


Ser Lys Ala Lys Gln Asp Pro Glu Glu Glu Lys Met His Phe His Asn 
625                 630                 635                 640 


Gly His Ile Lys Leu Pro Gly Val Arg Thr Tyr Ile Asp Pro His Thr 
                645                 650                 655     


Tyr Glu Asp Pro Asn Gln Ala Val His Glu Phe Ala Lys Glu Ile Glu 
            660                 665                 670         


Ala Ser Cys Ile Thr Ile Glu Arg Val Ile Gly Ala Gly Glu Phe Gly 
        675                 680                 685             


Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu Leu Pro 
    690                 695                 700                 


Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg 
705                 710                 715                 720 


Asp Phe Leu Gly Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn 
                725                 730                 735     


Ile Ile His Leu Glu Gly Val Val Thr Lys Ser Lys Pro Val Met Ile 
            740                 745                 750         


Val Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp Thr Phe Leu Lys Lys 
        755                 760                 765             


Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly 
    770                 775                 780                 


Ile Ser Ala Gly Met Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg 
785                 790                 795                 800 


Asp Leu Ala Ala Arg Asn Ile Leu Ile Asn Ser Asn Leu Val Cys Lys 
                805                 810                 815     


Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala 
            820                 825                 830         


Ala Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro 
        835                 840                 845             


Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser 
    850                 855                 860                 


Tyr Gly Ile Val Met Trp Glu Val Val Ser Tyr Gly Glu Arg Pro Tyr 
865                 870                 875                 880 


Trp Glu Met Thr Asn Gln Asp Val Ile Lys Ala Val Glu Glu Gly Tyr 
                885                 890                 895     


Arg Leu Pro Ser Pro Met Asp Cys Pro Ala Ala Leu Tyr Gln Leu Met 
            900                 905                 910         


Leu Asp Cys Trp Gln Lys Glu Arg Asn Ser Arg Pro Lys Phe Asp Glu 
        915                 920                 925             


Ile Val Asn Met Leu Asp Lys Leu Ile Arg Asn Pro Ser Ser Leu Lys 
    930                 935                 940                 


Thr Leu Val Asn Ala Ser Cys Arg Val Ser Asn Leu Leu Ala Glu His 
945                 950                 955                 960 


Ser Pro Leu Gly Ser Gly Ala Tyr Arg Ser Val Gly Glu Trp Leu Glu 
                965                 970                 975     


Ala Ile Lys Met Gly Arg Tyr Thr Glu Ile Phe Met Glu Asn Gly Tyr 
            980                 985                 990         


Ser Ser Met Asp Ala Val Ala Gln  Val Thr Leu Glu Asp  Leu Arg Arg 
        995                 1000                 1005             


Leu Gly  Val Thr Leu Val Gly  His Gln Lys Lys Ile  Met Asn Ser 
    1010                 1015                 1020             


Leu Gln  Glu Met Lys Val Gln  Leu Val Asn Gly Met  Val Pro Leu 
    1025                 1030                 1035             


<210>  3599
<211>  1130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHA6__Homo_sapiens__NP_001073917

<400>  3599

Met Gln Phe Pro Ser Pro Pro Ala Ala Arg Ser Ser Pro Ala Pro Gln 
1               5                   10                  15      


Ala Ala Ser Ser Ser Glu Ala Ala Ala Pro Ala Thr Gly Gln Pro Gly 
            20                  25                  30          


Pro Ser Cys Pro Val Pro Gly Thr Ser Arg Arg Gly Arg Pro Gly Thr 
        35                  40                  45              


Pro Pro Ala Gly Arg Val Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    50                  55                  60                  


Val Asp Lys Asp Pro His Pro Thr Gln Asn Thr Cys Leu Arg Cys Arg 
65                  70                  75                  80  


His Phe Ser Leu Arg Glu Arg Lys Arg Glu Pro Arg Arg Thr Met Gly 
                85                  90                  95      


Gly Cys Glu Val Arg Glu Phe Leu Leu Gln Phe Gly Phe Phe Leu Pro 
            100                 105                 110         


Leu Leu Thr Ala Trp Pro Gly Asp Cys Ser His Val Ser Asn Asn Gln 
        115                 120                 125             


Val Val Leu Leu Asp Thr Thr Thr Val Leu Gly Glu Leu Gly Trp Lys 
    130                 135                 140                 


Thr Tyr Pro Leu Asn Gly Trp Asp Ala Ile Thr Glu Met Asp Glu His 
145                 150                 155                 160 


Asn Arg Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Glu Pro Asn 
                165                 170                 175     


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Arg Asp Ala Ala Gln 
            180                 185                 190         


Lys Ile Tyr Val Glu Met Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile 
        195                 200                 205             


Pro Trp Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Phe Tyr Met 
    210                 215                 220                 


Glu Ser Asp Glu Ser His Gly Ile Lys Phe Lys Pro Asn Gln Tyr Thr 
225                 230                 235                 240 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu 
                245                 250                 255     


Gly Asp Arg Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro 
            260                 265                 270         


Ile Glu Arg Lys Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys 
        275                 280                 285             


Ile Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Phe Thr 
    290                 295                 300                 


Val Arg Asn Leu Ala Met Phe Pro Asp Thr Ile Pro Arg Val Asp Ser 
305                 310                 315                 320 


Ser Ser Leu Val Glu Val Arg Gly Ser Cys Val Lys Ser Ala Glu Glu 
                325                 330                 335     


Arg Asp Thr Pro Lys Leu Tyr Cys Gly Ala Asp Gly Asp Trp Leu Val 
            340                 345                 350         


Pro Leu Gly Arg Cys Ile Cys Ser Thr Gly Tyr Glu Glu Ile Glu Gly 
        355                 360                 365             


Ser Cys His Ala Cys Arg Pro Gly Phe Tyr Lys Ala Phe Ala Gly Asn 
    370                 375                 380                 


Thr Lys Cys Ser Lys Cys Pro Pro His Ser Leu Thr Tyr Met Glu Ala 
385                 390                 395                 400 


Thr Ser Val Cys Gln Cys Glu Lys Gly Tyr Phe Arg Ala Glu Lys Asp 
                405                 410                 415     


Pro Pro Ser Met Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Val 
            420                 425                 430         


Val Phe Asn Ile Asn Glu Thr Ala Leu Ile Leu Glu Trp Ser Pro Pro 
        435                 440                 445             


Ser Asp Thr Gly Gly Arg Lys Asp Leu Thr Tyr Ser Val Ile Cys Lys 
    450                 455                 460                 


Lys Cys Gly Leu Asp Thr Ser Gln Cys Glu Asp Cys Gly Gly Gly Leu 
465                 470                 475                 480 


Arg Phe Ile Pro Arg His Thr Gly Leu Ile Asn Asn Ser Val Ile Val 
                485                 490                 495     


Leu Asp Phe Val Ser His Val Asn Tyr Thr Phe Glu Ile Glu Ala Met 
            500                 505                 510         


Asn Gly Val Ser Glu Leu Ser Phe Ser Pro Lys Pro Phe Thr Ala Ile 
        515                 520                 525             


Thr Val Thr Thr Asp Gln Asp Ala Pro Ser Leu Ile Gly Val Val Arg 
    530                 535                 540                 


Lys Asp Trp Ala Ser Gln Asn Ser Ile Ala Leu Ser Trp Gln Ala Pro 
545                 550                 555                 560 


Ala Phe Ser Asn Gly Ala Ile Leu Asp Tyr Glu Ile Lys Tyr Tyr Glu 
                565                 570                 575     


Lys Glu His Glu Gln Leu Thr Tyr Ser Ser Thr Arg Ser Lys Ala Pro 
            580                 585                 590         


Ser Val Ile Ile Thr Gly Leu Lys Pro Ala Thr Lys Tyr Val Phe His 
        595                 600                 605             


Ile Arg Val Arg Thr Ala Thr Gly Tyr Ser Gly Tyr Ser Gln Lys Phe 
    610                 615                 620                 


Glu Phe Glu Thr Gly Asp Glu Thr Ser Asp Met Ala Ala Glu Gln Gly 
625                 630                 635                 640 


Gln Ile Leu Val Ile Ala Thr Ala Ala Val Gly Gly Phe Thr Leu Leu 
                645                 650                 655     


Val Ile Leu Thr Leu Phe Phe Leu Ile Thr Gly Arg Cys Gln Trp Tyr 
            660                 665                 670         


Ile Lys Ala Lys Met Lys Ser Glu Glu Lys Arg Arg Asn His Leu Gln 
        675                 680                 685             


Asn Gly His Leu Arg Phe Pro Gly Ile Lys Thr Tyr Ile Asp Pro Asp 
    690                 695                 700                 


Thr Tyr Glu Asp Pro Ser Leu Ala Val His Glu Phe Ala Lys Glu Ile 
705                 710                 715                 720 


Asp Pro Ser Arg Ile Arg Ile Glu Arg Val Ile Gly Ala Gly Glu Phe 
                725                 730                 735     


Gly Glu Val Cys Ser Gly Arg Leu Lys Thr Pro Gly Lys Arg Glu Ile 
            740                 745                 750         


Pro Val Ala Ile Lys Thr Leu Lys Gly Gly His Met Asp Arg Gln Arg 
        755                 760                 765             


Arg Asp Phe Leu Arg Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro 
    770                 775                 780                 


Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Arg Ser Phe Pro Ala 
785                 790                 795                 800 


Ile Gly Val Glu Ala Phe Cys Pro Ser Phe Leu Arg Ala Gly Phe Leu 
                805                 810                 815     


Asn Ser Ile Gln Ala Pro His Pro Val Pro Gly Gly Gly Ser Leu Pro 
            820                 825                 830         


Pro Arg Ile Pro Ala Gly Arg Pro Val Met Ile Val Val Glu Tyr Met 
        835                 840                 845             


Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Gly His Phe 
    850                 855                 860                 


Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met 
865                 870                 875                 880 


Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg 
                885                 890                 895     


Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly 
            900                 905                 910         


Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Thr 
        915                 920                 925             


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr 
    930                 935                 940                 


Arg Lys Phe Ser Ser Ala Ser Asp Ala Trp Ser Tyr Gly Ile Val Met 
945                 950                 955                 960 


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn 
                965                 970                 975     


Gln Asp Val Ile Leu Ser Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro 
            980                 985                 990         


Met Gly Cys Pro Ala Ser Leu His  Gln Leu Met Leu His  Cys Trp Gln 
        995                 1000                 1005             


Lys Glu  Arg Asn His Arg Pro  Lys Phe Thr Asp Ile  Val Ser Phe 
    1010                 1015                 1020             


Leu Asp  Lys Leu Ile Arg Asn  Pro Ser Ala Leu His  Thr Leu Val 
    1025                 1030                 1035             


Glu Asp  Ile Leu Val Met Pro  Glu Ser Pro Gly Glu  Val Pro Glu 
    1040                 1045                 1050             


Tyr Pro  Leu Phe Val Thr Val  Gly Asp Trp Leu Asp  Ser Ile Lys 
    1055                 1060                 1065             


Met Gly  Gln Tyr Lys Asn Asn  Phe Val Ala Ala Gly  Phe Thr Thr 
    1070                 1075                 1080             


Phe Asp  Leu Ile Ser Arg Met  Ser Ile Asp Asp Ile  Arg Arg Ile 
    1085                 1090                 1095             


Gly Val  Ile Leu Ile Gly His  Gln Arg Arg Ile Val  Ser Ser Ile 
    1100                 1105                 1110             


Gln Thr  Leu Arg Leu His Met  Met His Ile Gln Glu  Lys Gly Phe 
    1115                 1120                 1125             


His Val  
    1130 


<210>  3600
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHA7__Homo_sapiens__NP_001275559

<400>  3600

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Arg Lys 
        275                 


<210>  3601
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHB1__Homo_sapiens__NP_004432

<400>  3601

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala 
1               5                   10                  15      


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
            20                  25                  30          


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
        35                  40                  45              


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
    50                  55                  60                  


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
65                  70                  75                  80  


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                85                  90                  95      


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
            100                 105                 110         


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
        115                 120                 125             


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
    130                 135                 140                 


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
145                 150                 155                 160 


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                165                 170                 175     


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
            180                 185                 190         


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
        195                 200                 205             


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
    210                 215                 220                 


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
225                 230                 235                 240 


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                245                 250                 255     


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
            260                 265                 270         


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
        275                 280                 285             


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg 
    290                 295                 300                 


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
305                 310                 315                 320 


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                325                 330                 335     


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
            340                 345                 350         


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
        355                 360                 365             


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
    370                 375                 380                 


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
385                 390                 395                 400 


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                405                 410                 415     


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
            420                 425                 430         


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
        435                 440                 445             


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
    450                 455                 460                 


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
465                 470                 475                 480 


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                485                 490                 495     


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
            500                 505                 510         


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
        515                 520                 525             


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
    530                 535                 540                 


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
545                 550                 555                 560 


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                565                 570                 575     


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
            580                 585                 590         


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
        595                 600                 605             


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
    610                 615                 620                 


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
625                 630                 635                 640 


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                645                 650                 655     


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
            660                 665                 670         


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
        675                 680                 685             


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
    690                 695                 700                 


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
705                 710                 715                 720 


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala 
                725                 730                 735     


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
            740                 745                 750         


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
        755                 760                 765             


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
    770                 775                 780                 


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
865                 870                 875                 880 


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                885                 890                 895     


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
            900                 905                 910         


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
        915                 920                 925             


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
    930                 935                 940                 


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly 
945                 950                 955                 960 


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile 
                965                 970                 975     


Ser Gln Ser Pro Thr Ala Met Ala 
            980                 


<210>  3602
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHB3__Homo_sapiens__NP_004434

<400>  3602

Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser Pro Pro Pro Gly Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Pro 
            20                  25                  30          


Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met Asp Thr Lys Trp Val 
        35                  40                  45              


Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu Ser Gly Trp Glu Glu 
    50                  55                  60                  


Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile Arg Thr Tyr Gln Val 
65                  70                  75                  80  


Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Gly Phe 
                85                  90                  95      


Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val Glu Leu Lys Phe Thr 
            100                 105                 110         


Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro Gly Ser Cys Lys Glu 
        115                 120                 125             


Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser Asp Val Ala Ser Ala 
    130                 135                 140                 


Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val Lys Val Asp Thr Ile 
145                 150                 155                 160 


Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala Gly Arg Val Asn Thr 
                165                 170                 175     


Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu Ala 
            180                 185                 190         


Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile Ser Val Arg Ala Phe 
        195                 200                 205             


Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe Ala Leu Phe Pro Glu 
    210                 215                 220                 


Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val Ile Ala Pro Gly Thr 
225                 230                 235                 240 


Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro Leu Lys Leu Tyr Cys 
                245                 250                 255     


Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly Ala Cys Thr Cys Ala 
            260                 265                 270         


Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln Cys Arg Pro Cys Pro 
        275                 280                 285             


Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly Pro Cys Leu Pro Cys 
    290                 295                 300                 


Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala Ser Ile Cys Thr Cys 
305                 310                 315                 320 


His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser Ala Asp Ser Ala Cys 
                325                 330                 335     


Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile Ser Asn Val Asn Glu 
            340                 345                 350         


Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg Asp Leu Gly Gly Arg 
        355                 360                 365             


Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys Cys His Gly Ala Gly 
    370                 375                 380                 


Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro 
385                 390                 395                 400 


Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His Ile Ser His Leu Leu 
                405                 410                 415     


Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala Val Asn Gly Val Ser 
            420                 425                 430         


Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala Val Asn Ile Thr Thr 
        435                 440                 445             


Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu Arg Leu His Ser Ser 
    450                 455                 460                 


Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro Pro Glu Arg Pro Asn 
465                 470                 475                 480 


Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe Glu Lys Ser Glu Gly 
                485                 490                 495     


Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser Val Gln Leu Asp Gly 
            500                 505                 510         


Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val Arg Ala Arg Thr Val 
        515                 520                 525             


Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu Phe Glu Thr Thr Ser 
    530                 535                 540                 


Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu Gln Leu Pro Leu Ile 
545                 550                 555                 560 


Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val Val Ala Val Val Val 
                565                 570                 575     


Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His Gly Ser Asp Ser Glu 
            580                 585                 590         


Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro Gly Met Lys Val Tyr 
        595                 600                 605             


Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe 
    610                 615                 620                 


Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu Glu Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Gln Pro Gly 
                645                 650                 655     


Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser 
    690                 695                 700                 


Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Cys Ala Leu Asp 
705                 710                 715                 720 


Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser Glu Met 
            740                 745                 750         


Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu 
    770                 775                 780                 


Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile 
785                 790                 795                 800 


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr 
                805                 810                 815     


Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met 
            820                 825                 830         


Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile 
        835                 840                 845             


Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro 
    850                 855                 860                 


Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val Arg Asp Arg Asn 
865                 870                 875                 880 


Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu Asp Lys Leu Ile 
                885                 890                 895     


Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Ala Gln Ser Gly Met 
            900                 905                 910         


Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp Tyr Thr Thr Phe Thr 
        915                 920                 925             


Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met Gly Arg Tyr Lys Glu 
    930                 935                 940                 


Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp Leu Val Ala Gln Met 
945                 950                 955                 960 


Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln 
                965                 970                 975     


Lys Lys Ile Leu Ser Ser Ile Gln Asp Met Arg Leu Gln Met Asn Gln 
            980                 985                 990         


Thr Leu Pro Val Gln Val 
        995             


<210>  3603
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHB4__Homo_sapiens__NP_004435

<400>  3603

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu 
1               5                   10                  15      


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp 
            20                  25                  30          


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu 
        35                  40                  45              


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln 
    50                  55                  60                  


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu 
                85                  90                  95      


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr 
            100                 105                 110         


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro 
        115                 120                 125             


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu 
    130                 135                 140                 


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn 
145                 150                 155                 160 


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu 
            180                 185                 190         


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro 
        195                 200                 205             


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val 
    210                 215                 220                 


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg 
225                 230                 235                 240 


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala 
                245                 250                 255     


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala 
            260                 265                 270         


Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys 
        275                 280                 285             


Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys 
    290                 295                 300                 


Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys 
305                 310                 315                 320 


Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly 
                325                 330                 335     


Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg 
            340                 345                 350         


Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly 
        355                 360                 365             


Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg 
    370                 375                 380                 


Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe 
385                 390                 395                 400 


Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala 
                405                 410                 415     


Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu 
            420                 425                 430         


Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val 
    450                 455                 460                 


Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser 
465                 470                 475                 480 


Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly 
                485                 490                 495     


Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu 
            500                 505                 510         


Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu 
        515                 520                 525             


Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr 
    530                 535                 540                 


Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val 
545                 550                 555                 560 


Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp 
                565                 570                 575     


Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp 
            580                 585                 590         


Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys 
        595                 600                 605             


Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly 
    610                 615                 620                 


Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys 
625                 630                 635                 640 


Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg 
                645                 650                 655     


Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu 
            660                 665                 670         


His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro 
        675                 680                 685             


Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe 
    690                 695                 700                 


Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met 
705                 710                 715                 720 


Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr 
                725                 730                 735     


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu 
            740                 745                 750         


Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn 
        755                 760                 765             


Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile 
    770                 775                 780                 


Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala 
785                 790                 795                 800 


Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe 
                805                 810                 815     


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala 
            820                 825                 830         


Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser 
        835                 840                 845             


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg 
    850                 855                 860                 


Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn 
865                 870                 875                 880 


Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His 
                885                 890                 895     


Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val 
            900                 905                 910         


Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Glu Ser Phe 
        915                 920                 925             


Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala 
    930                 935                 940                 


Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys 
945                 950                 955                 960 


Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr 
                965                 970                 975     


Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr 
            980                 985         


<210>  3604
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHB6__Homo_sapiens__NP_001267724

<400>  3604

Met Val Ala Val Gly Gly Cys Arg Cys Gln Pro Gly Tyr Gln Pro Ala 
1               5                   10                  15      


Arg Gly Asp Lys Ala Cys Gln Ala Cys Pro Arg Gly Leu Tyr Lys Ala 
            20                  25                  30          


Ser Ala Gly Asn Ala Pro Cys Ser Pro Cys Pro Ala Arg Ser His Ala 
        35                  40                  45              


Pro Asn Pro Ala Ala Pro Val Cys Pro Cys Leu Glu Gly Phe Tyr Arg 
    50                  55                  60                  


Ala Ser Ser Asp Pro Pro Glu Ala Pro Cys Thr Gly Pro Pro Ser Ala 
65                  70                  75                  80  


Pro Gln Glu Leu Trp Phe Glu Val Gln Gly Ser Ala Leu Met Leu His 
                85                  90                  95      


Trp Arg Leu Pro Arg Glu Leu Gly Gly Arg Gly Asp Leu Leu Phe Asn 
            100                 105                 110         


Val Val Cys Lys Glu Cys Glu Gly Arg Gln Glu Pro Ala Ser Gly Gly 
        115                 120                 125             


Gly Gly Thr Cys His Arg Cys Arg Asp Glu Val His Phe Asp Pro Arg 
    130                 135                 140                 


Gln Arg Gly Leu Thr Glu Ser Arg Val Leu Val Gly Gly Leu Arg Ala 
145                 150                 155                 160 


His Val Pro Tyr Ile Leu Glu Val Gln Ala Val Asn Gly Val Ser Glu 
                165                 170                 175     


Leu Ser Pro Asp Pro Pro Gln Ala Ala Ala Ile Asn Val Ser Thr Ser 
            180                 185                 190         


His Glu Val Pro Ser Ala Val Pro Val Val His Gln Val Ser Arg Ala 
        195                 200                 205             


Ser Asn Ser Ile Thr Val Ser Trp Pro Gln Pro Asp Gln Thr Asn Gly 
    210                 215                 220                 


Asn Ile Leu Asp Tyr Gln Leu Arg Tyr Tyr Asp Gln Ala Glu Asp Glu 
225                 230                 235                 240 


Ser His Ser Phe Thr Leu Thr Ser Glu Thr Asn Thr Ala Thr Val Thr 
                245                 250                 255     


Gln Leu Ser Pro Gly His Ile Tyr Gly Phe Gln Val Arg Ala Arg Thr 
            260                 265                 270         


Ala Ala Gly His Gly Pro Tyr Gly Gly Lys Val Tyr Phe Gln Thr Leu 
        275                 280                 285             


Pro Gln Gly Glu Leu Ser Ser Gln Leu Pro Glu Arg Leu Ser Leu Val 
    290                 295                 300                 


Ile Gly Ser Ile Leu Gly Ala Leu Ala Phe Leu Leu Leu Ala Ala Ile 
305                 310                 315                 320 


Thr Val Leu Ala Val Val Phe Gln Arg Lys Arg Arg Gly Thr Gly Tyr 
                325                 330                 335     


Thr Glu Gln Leu Gln Gln Tyr Ser Ser Pro Gly Leu Gly Val Lys Tyr 
            340                 345                 350         


Tyr Ile Asp Pro Ser Thr Tyr Glu Asp Pro Cys Gln Ala Ile Arg Glu 
        355                 360                 365             


Leu Ala Arg Glu Val Asp Pro Ala Tyr Ile Lys Ile Glu Glu Val Ile 
    370                 375                 380                 


Gly Thr Gly Ser Phe Gly Glu Val Arg Gln Gly Arg Leu Gln Pro Arg 
385                 390                 395                 400 


Gly Arg Arg Glu Gln Thr Val Ala Ile Gln Ala Leu Trp Ala Gly Gly 
                405                 410                 415     


Ala Glu Ser Leu Gln Met Thr Phe Leu Gly Arg Ala Ala Val Leu Gly 
            420                 425                 430         


Gln Phe Gln His Pro Asn Ile Leu Arg Leu Glu Gly Val Val Thr Lys 
        435                 440                 445             


Ser Arg Pro Leu Met Val Leu Thr Glu Phe Met Glu Leu Gly Pro Leu 
    450                 455                 460                 


Asp Ser Phe Leu Arg Gln Arg Glu Gly Gln Phe Ser Ser Leu Gln Leu 
465                 470                 475                 480 


Val Ala Met Gln Arg Gly Val Ala Ala Ala Met Gln Tyr Leu Ser Ser 
                485                 490                 495     


Phe Ala Phe Val His Arg Ser Leu Ser Ala His Ser Val Leu Val Asn 
            500                 505                 510         


Ser His Leu Val Cys Lys Val Ala Arg Leu Gly His Ser Pro Gln Gly 
        515                 520                 525             


Pro Ser Cys Leu Leu Arg Trp Ala Ala Pro Glu Val Ile Ala His Gly 
    530                 535                 540                 


Lys His Thr Thr Ser Ser Asp Val Trp Ser Phe Gly Ile Leu Met Trp 
545                 550                 555                 560 


Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Glu Gln 
                565                 570                 575     


Glu Val Leu Asn Ala Ile Glu Gln Glu Phe Arg Leu Pro Pro Pro Pro 
            580                 585                 590         


Gly Cys Pro Pro Gly Leu His Leu Leu Met Leu Asp Thr Trp Gln Lys 
        595                 600                 605             


Asp Arg Ala Arg Arg Pro His Phe Asp Gln Leu Val Ala Ala Phe Asp 
    610                 615                 620                 


Lys Met Ile Arg Lys Pro Asp Thr Leu Gln Ala Gly Gly Asp Pro Gly 
625                 630                 635                 640 


Glu Arg Pro Ser Gln Ala Leu Leu Thr Pro Val Ala Leu Asp Phe Pro 
                645                 650                 655     


Cys Leu Asp Ser Pro Gln Ala Trp Leu Ser Ala Ile Gly Leu Glu Cys 
            660                 665                 670         


Tyr Gln Asp Asn Phe Ser Lys Phe Gly Leu Cys Thr Phe Ser Asp Val 
        675                 680                 685             


Ala Gln Leu Ser Leu Glu Asp Leu Pro Ala Leu Gly Ile Thr Leu Ala 
    690                 695                 700                 


Gly His Gln Lys Lys Leu Leu His His Ile Gln Leu Leu Gln Gln His 
705                 710                 715                 720 


Leu Arg Gln Gln Gly Ser Val Glu Val 
                725                 


<210>  3605
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHX1__Homo_sapiens__NP_000111

<400>  3605

Met Trp Leu Glu Ile Leu Leu Thr Ser Val Leu Gly Phe Ala Ile Tyr 
1               5                   10                  15      


Trp Phe Ile Ser Arg Asp Lys Glu Glu Thr Leu Pro Leu Glu Asp Gly 
            20                  25                  30          


Trp Trp Gly Pro Gly Thr Arg Ser Ala Ala Arg Glu Asp Asp Ser Ile 
        35                  40                  45              


Arg Pro Phe Lys Val Glu Thr Ser Asp Glu Glu Ile His Asp Leu His 
    50                  55                  60                  


Gln Arg Ile Asp Lys Phe Arg Phe Thr Pro Pro Leu Glu Asp Ser Cys 
65                  70                  75                  80  


Phe His Tyr Gly Phe Asn Ser Asn Tyr Leu Lys Lys Val Ile Ser Tyr 
                85                  90                  95      


Trp Arg Asn Glu Phe Asp Trp Lys Lys Gln Val Glu Ile Leu Asn Arg 
            100                 105                 110         


Tyr Pro His Phe Lys Thr Lys Ile Glu Gly Leu Asp Ile His Phe Ile 
        115                 120                 125             


His Val Lys Pro Pro Gln Leu Pro Ala Gly His Thr Pro Lys Pro Leu 
    130                 135                 140                 


Leu Met Val His Gly Trp Pro Gly Ser Phe Tyr Glu Phe Tyr Lys Ile 
145                 150                 155                 160 


Ile Pro Leu Leu Thr Asp Pro Lys Asn His Gly Leu Ser Asp Glu His 
                165                 170                 175     


Val Phe Glu Val Ile Cys Pro Ser Ile Pro Gly Tyr Gly Phe Ser Glu 
            180                 185                 190         


Ala Ser Ser Lys Lys Gly Phe Asn Ser Val Ala Thr Ala Arg Ile Phe 
        195                 200                 205             


Tyr Lys Leu Met Leu Arg Leu Gly Phe Gln Glu Phe Tyr Ile Gln Gly 
    210                 215                 220                 


Gly Asp Trp Gly Ser Leu Ile Cys Thr Asn Met Ala Gln Leu Val Pro 
225                 230                 235                 240 


Ser His Val Lys Gly Leu His Leu Asn Met Ala Leu Val Leu Ser Asn 
                245                 250                 255     


Phe Ser Thr Leu Thr Leu Leu Leu Gly Gln Arg Phe Gly Arg Phe Leu 
            260                 265                 270         


Gly Leu Thr Glu Arg Asp Val Glu Leu Leu Tyr Pro Val Lys Glu Lys 
        275                 280                 285             


Val Phe Tyr Ser Leu Met Arg Glu Ser Gly Tyr Met His Ile Gln Cys 
    290                 295                 300                 


Thr Lys Pro Asp Thr Val Gly Ser Ala Leu Asn Asp Ser Pro Val Gly 
305                 310                 315                 320 


Leu Ala Ala Tyr Ile Leu Glu Lys Phe Ser Thr Trp Thr Asn Thr Glu 
                325                 330                 335     


Phe Arg Tyr Leu Glu Asp Gly Gly Leu Glu Arg Lys Phe Ser Leu Asp 
            340                 345                 350         


Asp Leu Leu Thr Asn Val Met Leu Tyr Trp Thr Thr Gly Thr Ile Ile 
        355                 360                 365             


Ser Ser Gln Arg Phe Tyr Lys Glu Asn Leu Gly Gln Gly Trp Met Thr 
    370                 375                 380                 


Gln Lys His Glu Arg Met Lys Val Tyr Val Pro Thr Gly Phe Ser Ala 
385                 390                 395                 400 


Phe Pro Phe Glu Leu Leu His Thr Pro Glu Lys Trp Val Arg Phe Lys 
                405                 410                 415     


Tyr Pro Lys Leu Ile Ser Tyr Ser Tyr Met Val Arg Gly Gly His Phe 
            420                 425                 430         


Ala Ala Phe Glu Glu Pro Glu Leu Leu Ala Gln Asp Ile Arg Lys Phe 
        435                 440                 445             


Leu Ser Val Leu Glu Arg Gln 
    450                 455 


<210>  3606
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHX2__Homo_sapiens__NP_001243411

<400>  3606

Met Lys Gly Glu Ile Thr Leu Ser Gln Trp Ile Pro Leu Met Glu Glu 
1               5                   10                  15      


Asn Cys Arg Lys Cys Ser Glu Thr Ala Lys Val Cys Leu Pro Lys Asn 
            20                  25                  30          


Phe Ser Ile Lys Glu Ile Phe Asp Lys Ala Ile Ser Ala Arg Lys Ile 
        35                  40                  45              


Asn Arg Pro Met Leu Gln Ala Ala Leu Met Leu Arg Lys Lys Gly Phe 
    50                  55                  60                  


Thr Thr Ala Ile Leu Thr Asn Thr Trp Leu Asp Asp Arg Ala Glu Arg 
65                  70                  75                  80  


Asp Gly Leu Ala Gln Leu Met Cys Glu Leu Lys Met His Phe Asp Phe 
                85                  90                  95      


Leu Ile Glu Ser Cys Gln Val Gly Met Val Lys Pro Glu Pro Gln Ile 
            100                 105                 110         


Tyr Lys Phe Leu Leu Asp Thr Leu Lys Ala Ser Pro Ser Glu Val Val 
        115                 120                 125             


Phe Leu Asp Asp Ile Gly Ala Asn Leu Lys Pro Ala Arg Asp Leu Gly 
    130                 135                 140                 


Met Val Thr Ile Leu Val Gln Asp Thr Asp Thr Ala Leu Lys Glu Leu 
145                 150                 155                 160 


Glu Lys Val Thr Gly Ile Gln Leu Leu Asn Thr Pro Ala Pro Leu Pro 
                165                 170                 175     


Thr Ser Cys Asn Pro Ser Asp Met Ser His Gly Tyr Val Thr Val Lys 
            180                 185                 190         


Pro Arg Val Arg Leu His Phe Val Glu Leu Gly Ser Gly Pro Ala Val 
        195                 200                 205             


Cys Leu Cys His Gly Phe Pro Glu Ser Trp Tyr Ser Trp Arg Tyr Gln 
    210                 215                 220                 


Ile Pro Ala Leu Ala Gln Ala Gly Tyr Arg Val Leu Ala Met Asp Met 
225                 230                 235                 240 


Lys Gly Tyr Gly Glu Ser Ser Ala Pro Pro Glu Ile Glu Glu Tyr Cys 
                245                 250                 255     


Met Glu Val Leu Cys Lys Glu Met Val Thr Phe Leu Asp Lys Leu Gly 
            260                 265                 270         


Leu Ser Gln Ala Val Phe Ile Gly His Asp Trp Gly Gly Met Leu Val 
        275                 280                 285             


Trp Tyr Met Ala Leu Phe Tyr Pro Glu Arg Val Arg Ala Val Ala Ser 
    290                 295                 300                 


Leu Asn Thr Pro Phe Ile Pro Ala Asn Pro Asn Met Ser Pro Leu Glu 
305                 310                 315                 320 


Ser Ile Lys Ala Asn Pro Val Phe Asp Tyr Gln Leu Tyr Phe Gln Glu 
                325                 330                 335     


Pro Gly Val Ala Glu Ala Glu Leu Glu Gln Asn Leu Ser Arg Thr Phe 
            340                 345                 350         


Lys Ser Leu Phe Arg Ala Ser Asp Glu Ser Val Leu Ser Met His Lys 
        355                 360                 365             


Val Cys Glu Ala Gly Gly Leu Phe Val Asn Ser Pro Glu Glu Pro Ser 
    370                 375                 380                 


Leu Ser Arg Met Val Thr Glu Glu Glu Ile Gln Phe Tyr Val Gln Gln 
385                 390                 395                 400 


Phe Lys Lys Ser Gly Phe Arg Gly Pro Leu Asn Trp Tyr Arg Asn Met 
                405                 410                 415     


Glu Arg Asn Trp Lys Trp Ala Cys Lys Ser Leu Gly Arg Lys Ile Leu 
            420                 425                 430         


Ile Pro Ala Leu Met Val Thr Ala Glu Lys Asp Phe Val Leu Val Pro 
        435                 440                 445             


Gln Met Ser Gln His Met Glu Asp Trp Ile Pro His Leu Lys Arg Gly 
    450                 455                 460                 


His Ile Glu Asp Cys Gly His Trp Thr Gln Met Asp Lys Pro Thr Glu 
465                 470                 475                 480 


Val Asn Gln Ile Leu Ile Lys Trp Leu Asp Ser Asp Ala Arg Asn Pro 
                485                 490                 495     


Pro Val Val Ser Lys Met 
            500         


<210>  3607
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPHX3__Homo_sapiens__NP_001136358

<400>  3607

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val Val Ala 
        115                 120                 125             


Val Asp Leu Arg Gly Tyr Gly Pro Ser Asp Ala Pro Arg Asp Val Asp 
    130                 135                 140                 


Cys Tyr Thr Ile Asp Leu Leu Leu Val Asp Ile Lys Asp Val Ile Leu 
145                 150                 155                 160 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ala His Asp Trp Gly Ala 
                165                 170                 175     


Leu Leu Ala Trp His Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
            180                 185                 190         


Met Val Val Val Ser Gly Ala Pro Met Ser Val Tyr Gln Asp Tyr Ser 
        195                 200                 205             


Leu His His Ile Ser Gln Phe Phe Arg Ser His Tyr Met Phe Leu Phe 
    210                 215                 220                 


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
225                 230                 235                 240 


Ile Leu Lys Thr Thr Leu Thr His Arg Lys Thr Gly Ile Pro Cys Leu 
                245                 250                 255     


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr Asn Phe Ser Gln Pro Gly 
            260                 265                 270         


Gly Leu Thr Gly Pro Leu Asn Tyr Tyr Arg Asn Leu Phe Arg Asn Phe 
        275                 280                 285             


Pro Leu Glu Pro Gln Glu Leu Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Lys Asp Thr Tyr Leu Glu Leu Gly Leu Val Glu Ala Ile Gly Ser 
305                 310                 315                 320 


Arg Phe Val Pro Gly Arg Leu Glu Ala His Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


His Trp Ile Pro Gln Ser Asn Pro Gln Glu Met His Gln Tyr Met Trp 
            340                 345                 350         


Ala Phe Leu Gln Asp Leu Leu Asp 
        355                 360 


<210>  3608
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPM2A__Homo_sapiens__NP_001018051

<400>  3608

Met Arg Phe Arg Phe Gly Val Val Val Pro Pro Ala Val Ala Gly Ala 
1               5                   10                  15      


Arg Pro Glu Leu Leu Val Val Gly Ser Arg Pro Glu Leu Gly Arg Trp 
            20                  25                  30          


Glu Pro Arg Gly Ala Val Arg Leu Arg Pro Ala Gly Thr Ala Ala Gly 
        35                  40                  45              


Asp Gly Ala Leu Ala Leu Gln Glu Pro Gly Leu Trp Leu Gly Glu Val 
    50                  55                  60                  


Glu Leu Ala Ala Glu Glu Ala Ala Gln Asp Gly Ala Glu Pro Gly Arg 
65                  70                  75                  80  


Val Asp Thr Phe Trp Tyr Lys Phe Leu Lys Arg Glu Pro Gly Gly Glu 
                85                  90                  95      


Leu Ser Trp Glu Gly Asn Gly Pro His His Asp Arg Cys Cys Thr Tyr 
            100                 105                 110         


Asn Glu Asn Asn Leu Val Asp Gly Val Tyr Cys Leu Pro Ile Gly His 
        115                 120                 125             


Trp Ile Glu Ala Thr Gly His Thr Asn Glu Met Lys His Thr Thr Asp 
    130                 135                 140                 


Phe Tyr Phe Asn Ile Ala Gly His Gln Ala Met His Tyr Ser Arg Ile 
145                 150                 155                 160 


Leu Pro Asn Ile Trp Leu Gly Ser Cys Pro Arg Gln Val Glu His Val 
                165                 170                 175     


Thr Ile Lys Leu Lys His Glu Leu Gly Ile Thr Ala Val Met Asn Phe 
            180                 185                 190         


Gln Thr Glu Trp Asp Ile Val Gln Asn Ser Ser Gly Cys Asn Arg Tyr 
        195                 200                 205             


Pro Glu Pro Met Thr Pro Asp Thr Met Ile Lys Leu Tyr Arg Glu Glu 
    210                 215                 220                 


Gly Leu Ala Tyr Ile Trp Met Pro Thr Pro Asp Met Ser Thr Glu Gly 
225                 230                 235                 240 


Arg Val Gln Met Leu Pro Gln Ala Val Cys Leu Leu His Ala Leu Leu 
                245                 250                 255     


Glu Lys Gly His Ile Val Tyr Val His Cys Asn Ala Gly Val Gly Arg 
            260                 265                 270         


Ser Thr Ala Ala Val Cys Gly Trp Leu Gln Tyr Val Met Gly Trp Asn 
        275                 280                 285             


Leu Arg Lys Val Gln Tyr Phe Leu Met Ala Lys Arg Pro Ala Val Tyr 
    290                 295                 300                 


Ile Asp Glu Glu Ala Ala Ser Gln Asp Thr Phe Pro Leu 
305                 310                 315         


<210>  3609
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPM2AIP1__Homo_sapiens__NP_055620

<400>  3609

Met Trp Met Thr Pro Lys Arg Ser Lys Met Glu Val Asp Glu Ala Leu 
1               5                   10                  15      


Val Phe Arg Pro Glu Trp Thr Gln Arg Tyr Leu Val Val Glu Pro Pro 
            20                  25                  30          


Glu Gly Asp Gly Ala Leu Cys Leu Val Cys Arg Arg Leu Ile Val Ala 
        35                  40                  45              


Thr Arg Glu Arg Asp Val Arg Arg His Tyr Glu Ala Glu His Glu Tyr 
    50                  55                  60                  


Tyr Glu Arg Tyr Val Ala Asp Gly Glu Arg Ala Ala Leu Val Glu Arg 
65                  70                  75                  80  


Leu Arg Gln Gly Asp Leu Pro Val Ala Ser Phe Thr Pro Glu Glu Arg 
                85                  90                  95      


Ala Ala Arg Ala Gly Leu Gly Leu Cys Arg Leu Leu Ala Leu Lys Gly 
            100                 105                 110         


Arg Gly Trp Gly Glu Gly Asp Phe Val Tyr Gln Cys Met Glu Val Leu 
        115                 120                 125             


Leu Arg Glu Val Leu Pro Glu His Val Ser Val Leu Gln Gly Val Asp 
    130                 135                 140                 


Leu Ser Pro Asp Ile Thr Arg Gln Arg Ile Leu Ser Ile Asp Arg Asn 
145                 150                 155                 160 


Leu Arg Asn Gln Leu Phe Asn Arg Ala Arg Asp Phe Lys Ala Tyr Ser 
                165                 170                 175     


Leu Ala Leu Asp Asp Gln Ala Phe Val Ala Tyr Glu Asn Tyr Leu Leu 
            180                 185                 190         


Val Phe Ile Arg Gly Val Gly Pro Glu Leu Glu Val Gln Glu Asp Leu 
        195                 200                 205             


Leu Thr Ile Ile Asn Leu Thr His His Phe Ser Val Gly Ala Leu Met 
    210                 215                 220                 


Ser Ala Ile Leu Glu Ser Leu Gln Thr Ala Gly Leu Ser Leu Gln Arg 
225                 230                 235                 240 


Met Val Gly Leu Thr Thr Thr His Thr Leu Arg Met Ile Gly Glu Asn 
                245                 250                 255     


Ser Gly Leu Val Ser Tyr Met Arg Glu Lys Ala Val Ser Pro Asn Cys 
            260                 265                 270         


Trp Asn Val Ile His Tyr Ser Gly Phe Leu His Leu Glu Leu Leu Ser 
        275                 280                 285             


Ser Tyr Asp Val Asp Val Asn Gln Ile Ile Asn Thr Ile Ser Glu Trp 
    290                 295                 300                 


Ile Val Leu Ile Lys Thr Arg Gly Val Arg Arg Pro Glu Phe Gln Thr 
305                 310                 315                 320 


Leu Leu Thr Glu Ser Glu Ser Glu His Gly Glu Arg Val Asn Gly Arg 
                325                 330                 335     


Cys Leu Asn Asn Trp Leu Arg Arg Gly Lys Thr Leu Lys Leu Ile Phe 
            340                 345                 350         


Ser Leu Arg Lys Glu Met Glu Ala Phe Leu Val Ser Val Gly Ala Thr 
        355                 360                 365             


Thr Val His Phe Ser Asp Lys Gln Trp Leu Cys Asp Phe Gly Phe Leu 
    370                 375                 380                 


Val Asp Ile Met Glu His Leu Arg Glu Leu Ser Glu Glu Leu Arg Val 
385                 390                 395                 400 


Ser Lys Val Phe Ala Ala Ala Ala Phe Asp His Ile Cys Thr Phe Glu 
                405                 410                 415     


Val Lys Leu Asn Leu Phe Gln Arg His Ile Glu Glu Lys Asn Leu Thr 
            420                 425                 430         


Asp Phe Pro Ala Leu Arg Glu Val Val Asp Glu Leu Lys Gln Gln Asn 
        435                 440                 445             


Lys Glu Asp Glu Lys Ile Phe Asp Pro Asp Arg Tyr Gln Met Val Ile 
    450                 455                 460                 


Cys Arg Leu Gln Lys Glu Phe Glu Arg His Phe Lys Asp Leu Arg Phe 
465                 470                 475                 480 


Ile Lys Lys Asp Leu Glu Leu Phe Ser Asn Pro Phe Asn Phe Lys Pro 
                485                 490                 495     


Glu Tyr Ala Pro Ile Ser Val Arg Val Glu Leu Thr Lys Leu Gln Ala 
            500                 505                 510         


Asn Thr Asn Leu Trp Asn Glu Tyr Arg Ile Lys Asp Leu Gly Gln Phe 
        515                 520                 525             


Tyr Ala Gly Leu Ser Ala Glu Ser Tyr Pro Ile Ile Lys Gly Val Ala 
    530                 535                 540                 


Cys Lys Val Ala Ser Leu Phe Asp Ser Asn Gln Ile Cys Glu Lys Ala 
545                 550                 555                 560 


Phe Ser Tyr Leu Thr Arg Asn Gln His Thr Leu Ser Gln Pro Leu Thr 
                565                 570                 575     


Asp Glu His Leu Gln Ala Leu Phe Arg Val Ala Thr Thr Glu Met Glu 
            580                 585                 590         


Pro Gly Trp Asp Asp Leu Val Arg Glu Arg Asn Glu Ser Asn Pro 
        595                 600                 605         


<210>  3610
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPN1__Homo_sapiens__NP_001123543

<400>  3610

Met Gly Asp Gln Ser Trp Leu Trp Asn Gln Ala Ala Pro Gly Val Arg 
1               5                   10                  15      


Ser Pro Val Phe Ala Cys Ser Val Glu Lys Gly Asn Val Pro Leu Val 
            20                  25                  30          


Leu Ser Glu His Leu Ala His Ser Arg Asp Pro Gly Ser Gly Ala Val 
        35                  40                  45              


Arg Phe Leu Ile Ser Pro Glu Pro Trp Ala Ser Ala Ile Leu Gly Thr 
    50                  55                  60                  


Ser Gly Leu Leu Ala Ser Pro Val Leu Pro Ala Ala Leu Asp Ala Val 
65                  70                  75                  80  


Thr Cys Gln His Leu Pro Gln Pro Ser Ser Gly Ser Arg Pro Ile Ser 
                85                  90                  95      


Pro Arg Ile Gly Ala Leu Cys Pro Leu Leu Leu Gln Pro Gly Thr Met 
            100                 105                 110         


Ser Thr Ser Ser Leu Arg Arg Gln Met Lys Asn Ile Val His Asn Tyr 
        115                 120                 125             


Ser Glu Ala Glu Ile Lys Val Arg Glu Ala Thr Ser Asn Asp Pro Trp 
    130                 135                 140                 


Gly Pro Ser Ser Ser Leu Met Ser Glu Ile Ala Asp Leu Thr Tyr Asn 
145                 150                 155                 160 


Val Val Ala Phe Ser Glu Ile Met Ser Met Ile Trp Lys Arg Leu Asn 
                165                 170                 175     


Asp His Gly Lys Asn Trp Arg His Val Tyr Lys Ala Met Thr Leu Met 
            180                 185                 190         


Glu Tyr Leu Ile Lys Thr Gly Ser Glu Arg Val Ser Gln Gln Cys Lys 
        195                 200                 205             


Glu Asn Met Tyr Ala Val Gln Thr Leu Lys Asp Phe Gln Tyr Val Asp 
    210                 215                 220                 


Arg Asp Gly Lys Asp Gln Gly Val Asn Val Arg Glu Lys Ala Lys Gln 
225                 230                 235                 240 


Leu Val Ala Leu Leu Arg Asp Glu Asp Arg Leu Arg Glu Glu Arg Ala 
                245                 250                 255     


His Ala Leu Lys Thr Lys Glu Lys Leu Ala Gln Thr Ala Thr Ala Ser 
            260                 265                 270         


Ser Ala Ala Val Gly Ser Gly Pro Pro Pro Glu Ala Glu Gln Ala Trp 
        275                 280                 285             


Pro Gln Ser Ser Gly Glu Glu Glu Leu Gln Leu Gln Leu Ala Leu Ala 
    290                 295                 300                 


Met Ser Lys Glu Glu Ala Asp Gln Glu Glu Arg Ile Arg Arg Gly Asp 
305                 310                 315                 320 


Asp Leu Arg Leu Gln Met Ala Ile Glu Glu Ser Lys Arg Glu Thr Gly 
                325                 330                 335     


Gly Lys Glu Glu Ser Ser Leu Met Asp Leu Ala Asp Val Phe Thr Ala 
            340                 345                 350         


Pro Ala Pro Ala Pro Thr Thr Asp Pro Trp Gly Gly Pro Ala Pro Met 
        355                 360                 365             


Ala Ala Ala Val Pro Thr Ala Ala Pro Thr Ser Asp Pro Trp Gly Gly 
    370                 375                 380                 


Pro Pro Val Pro Pro Ala Ala Asp Pro Trp Gly Gly Pro Ala Pro Thr 
385                 390                 395                 400 


Pro Ala Ser Gly Asp Pro Trp Arg Pro Ala Ala Pro Ala Gly Pro Ser 
                405                 410                 415     


Val Asp Pro Trp Gly Gly Thr Pro Ala Pro Ala Ala Gly Glu Gly Pro 
            420                 425                 430         


Thr Pro Asp Pro Trp Gly Ser Ser Asp Gly Gly Val Pro Val Ser Gly 
        435                 440                 445             


Pro Ser Ala Ser Asp Pro Trp Thr Pro Ala Pro Ala Phe Ser Asp Pro 
    450                 455                 460                 


Trp Gly Gly Ser Pro Ala Lys Pro Ser Thr Asn Gly Thr Thr Ala Ala 
465                 470                 475                 480 


Gly Gly Phe Asp Thr Glu Pro Asp Glu Phe Ser Asp Phe Asp Arg Leu 
                485                 490                 495     


Arg Thr Ala Leu Pro Thr Ser Gly Ser Ser Ala Gly Glu Leu Glu Leu 
            500                 505                 510         


Leu Ala Gly Glu Val Pro Ala Arg Ser Pro Gly Ala Phe Asp Met Ser 
        515                 520                 525             


Gly Val Arg Gly Ser Leu Ala Glu Ala Val Gly Ser Pro Pro Pro Ala 
    530                 535                 540                 


Ala Thr Pro Thr Pro Thr Pro Pro Thr Arg Lys Thr Pro Glu Ser Phe 
545                 550                 555                 560 


Leu Gly Pro Asn Ala Ala Leu Val Asp Leu Asp Ser Leu Val Ser Arg 
                565                 570                 575     


Pro Gly Pro Thr Pro Pro Gly Ala Lys Ala Ser Asn Pro Phe Leu Pro 
            580                 585                 590         


Gly Gly Gly Pro Ala Thr Gly Pro Ser Val Thr Asn Pro Phe Gln Pro 
        595                 600                 605             


Ala Pro Pro Ala Thr Leu Thr Leu Asn Gln Leu Arg Leu Ser Pro Val 
    610                 615                 620                 


Pro Pro Val Pro Gly Ala Pro Pro Thr Tyr Ile Ser Pro Leu Gly Gly 
625                 630                 635                 640 


Gly Pro Gly Leu Pro Pro Met Met Pro Pro Gly Pro Pro Ala Pro Asn 
                645                 650                 655     


Thr Asn Pro Phe Leu Leu 
            660         


<210>  3611
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPO__Homo_sapiens__NP_000790

<400>  3611

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu 
            20                  25                  30          


Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu Leu Glu Ala Lys Glu 
        35                  40                  45              


Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His Cys Ser Leu Asn Glu 
    50                  55                  60                  


Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ala Trp Lys Arg 
65                  70                  75                  80  


Met Glu Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu 
                85                  90                  95      


Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu Leu Val Asn Ser Ser 
            100                 105                 110         


Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp Lys Ala Val Ser Gly 
        115                 120                 125             


Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu 
    130                 135                 140                 


Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Ile 
145                 150                 155                 160 


Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val Tyr Ser Asn Phe Leu 
                165                 170                 175     


Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Thr Gly Asp 
            180                 185                 190         


Arg 
    


<210>  3612
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPOR__Homo_sapiens__NP_000112

<400>  3612

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Leu Pro Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser 
        115                 120                 125             


Gly Ala Pro Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu 
    130                 135                 140                 


Leu Asp Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly 
145                 150                 155                 160 


His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser 
                165                 170                 175     


His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser 
            180                 185                 190         


Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val 
225                 230                 235                 240 


Ser Leu Leu Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
                245                 250                 255     


Leu Ile Leu Val Val Ile Leu Val Leu Leu Thr Val Leu Ala Leu Leu 
            260                 265                 270         


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
        275                 280                 285             


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
    290                 295                 300                 


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
305                 310                 315                 320 


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
                325                 330                 335     


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
                405                 410                 415     


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
465                 470                 475                 480 


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505             


<210>  3613
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPPIN__Homo_sapiens__NP_001289790

<400>  3613

Met Gly Ser Ser Gly Leu Leu Ser Leu Leu Val Leu Phe Val Leu Leu 
1               5                   10                  15      


Ala Asn Val Gln Gly Pro Gly Leu Thr Asp Trp Leu Phe Pro Arg Arg 
            20                  25                  30          


Cys Pro Lys Ile Arg Glu Glu Cys Glu Phe Gln Glu Arg Asp Val Cys 
        35                  40                  45              


Thr Lys Asp Arg Gln Cys Gln Asp Asn Lys Lys Cys Cys Val Phe Ser 
    50                  55                  60                  


Cys Gly Lys Lys Cys Leu Asp Leu Lys Gln Val Ser Leu Gln Met Tyr 
65                  70                  75                  80  


Ala Lys Cys Gln Lys Lys Leu Ala Pro Ala Trp Leu Ile Phe Phe Ile 
                85                  90                  95      


Gly Gly Met Thr Arg Lys Ile Ile Leu Ala Pro Cys Leu Ser Met Val 
            100                 105                 110         


Ala Ala Arg Glu Thr Ile Thr Thr Ser Asn Pro Lys Pro Thr Ala 
        115                 120                 125         


<210>  3614
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPPIN-WFDC6__Homo_sapiens__NP_001185915

<400>  3614

Met Gly Ser Ser Gly Leu Leu Ser Leu Leu Val Leu Phe Val Leu Leu 
1               5                   10                  15      


Ala Asn Val Gln Gly Pro Gly Leu Thr Asp Trp Leu Phe Pro Arg Arg 
            20                  25                  30          


Cys Pro Lys Ile Arg Glu Glu Cys Glu Phe Gln Glu Arg Asp Val Cys 
        35                  40                  45              


Thr Lys Asp Arg Gln Cys Gln Asp Asn Lys Lys Cys Cys Val Phe Ser 
    50                  55                  60                  


Cys Gly Lys Lys Cys Leu Asp Leu Lys Gln Asp Val Cys Glu Met Pro 
65                  70                  75                  80  


Lys Glu Thr Gly Pro Cys Leu Ala Tyr Phe Leu His Trp Trp Tyr Asp 
                85                  90                  95      


Lys Lys Asp Asn Thr Cys Ser Met Phe Val Tyr Gly Gly Cys Gln Gly 
            100                 105                 110         


Asn Asn Asn Asn Phe Gln Ser Lys Ala Asn Cys Leu Asn Thr Cys Lys 
        115                 120                 125             


Asn Lys Gln Pro Cys Pro Lys Ile Lys Val Glu Cys Glu Val Glu Glu 
    130                 135                 140                 


Ile Asp Gln Cys Thr Lys Pro Arg Asp Cys Pro Glu Asn Met Lys Cys 
145                 150                 155                 160 


Cys Pro Phe Ser Arg Gly Lys Lys Cys Leu Asp Phe Arg Lys Ala Ser 
                165                 170                 175     


Leu Ser Thr 
            


<210>  3615
<211>  5088
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPPK1__Homo_sapiens__XP_011515627

<400>  3615

Met Ser Gly His Thr Leu Pro Pro Leu Pro Val Pro Gly Thr Asn Ser 
1               5                   10                  15      


Thr Glu Gln Ala Ser Val Pro Arg Ala Met Ala Ala Thr Leu Gly Ala 
            20                  25                  30          


Gly Thr Pro Pro Arg Pro Gln Ala Arg Ser Ile Ala Gly Val Tyr Val 
        35                  40                  45              


Glu Ala Ser Gly Gln Ala Gln Ser Val Tyr Ala Ala Met Glu Gln Gly 
    50                  55                  60                  


Leu Leu Pro Ala Gly Leu Gly Gln Ala Leu Leu Glu Ala Gln Ala Ala 
65                  70                  75                  80  


Thr Gly Gly Leu Val Asp Leu Ala Arg Gly Gln Leu Leu Pro Val Ser 
                85                  90                  95      


Lys Ala Leu Gln Gln Gly Leu Val Gly Leu Glu Leu Lys Glu Lys Leu 
            100                 105                 110         


Leu Ala Ala Glu Arg Ala Thr Thr Gly Tyr Pro Asp Pro Tyr Gly Gly 
        115                 120                 125             


Glu Lys Leu Ala Leu Phe Gln Ala Ile Gly Lys Glu Val Val Asp Arg 
    130                 135                 140                 


Ala Leu Gly Gln Ser Trp Leu Glu Val Gln Leu Ala Thr Gly Gly Leu 
145                 150                 155                 160 


Val Asp Pro Ala Gln Gly Val Leu Val Ala Pro Glu Pro Ala Cys His 
                165                 170                 175     


Gln Gly Leu Leu Asp Arg Glu Thr Trp His Lys Leu Ser Glu Leu Glu 
            180                 185                 190         


Pro Gly Thr Gly Asp Leu Arg Phe Leu Asp Pro Asn Thr Leu Glu Arg 
        195                 200                 205             


Leu Thr Tyr His Gln Leu Leu Glu Arg Cys Val Arg Ala Pro Gly Ser 
    210                 215                 220                 


Gly Leu Ala Leu Leu Pro Leu Lys Ile Thr Phe Arg Ser Met Gly Gly 
225                 230                 235                 240 


Ala Val Ser Ala Ala Glu Leu Leu Glu Val Gly Ile Leu Asp Glu Gln 
                245                 250                 255     


Ala Val Gln Gly Leu Arg Glu Gly Arg Leu Ala Ala Val Asp Val Ser 
            260                 265                 270         


Ala Arg Ala Glu Val Arg Arg Tyr Leu Glu Gly Thr Gly Ser Val Ala 
        275                 280                 285             


Gly Val Val Leu Leu Pro Glu Gly His Lys Lys Ser Phe Phe Gln Ala 
    290                 295                 300                 


Ala Thr Glu His Leu Leu Pro Met Gly Thr Ala Leu Pro Leu Leu Glu 
305                 310                 315                 320 


Ala Gln Ala Ala Thr His Thr Leu Val Asp Pro Ile Thr Gly Gln Arg 
                325                 330                 335     


Leu Trp Val Asp Glu Ala Val Arg Ala Gly Leu Val Ser Pro Glu Leu 
            340                 345                 350         


His Glu Gln Leu Leu Val Ala Glu Gln Ala Val Thr Gly His His Asp 
        355                 360                 365             


Pro Phe Ser Gly Ser Gln Ile Pro Leu Phe Gln Ala Met Lys Lys Gly 
    370                 375                 380                 


Leu Val Asp Arg Pro Leu Ala Leu Arg Leu Leu Asp Ala Gln Leu Ala 
385                 390                 395                 400 


Thr Gly Gly Leu Val Cys Pro Ala Arg Arg Leu Arg Leu Pro Leu Glu 
                405                 410                 415     


Ala Ala Leu Arg Cys Gly Cys Leu Asp Glu Asp Thr Gln Arg Gln Leu 
            420                 425                 430         


Ser Gln Ala Gly Ser Phe Ser Asp Gly Thr His Gly Gly Leu Arg Tyr 
        435                 440                 445             


Glu Gln Leu Leu Ala Leu Cys Val Thr Asp Pro Glu Thr Gly Leu Ala 
    450                 455                 460                 


Phe Leu Pro Leu Ser Gly Gly Pro Arg Gly Gly Glu Pro Gln Gly Pro 
465                 470                 475                 480 


Pro Phe Ile Lys Tyr Ser Thr Arg Gln Ala Leu Ser Thr Ala Thr Ala 
                485                 490                 495     


Thr Val Ser Val Gly Lys Phe Arg Gly Arg Pro Val Ser Leu Trp Glu 
            500                 505                 510         


Leu Leu Phe Ser Glu Ala Ile Ser Ser Glu Gln Arg Ala Met Leu Ala 
        515                 520                 525             


Gln Gln Tyr Gln Glu Gly Thr Leu Ser Val Glu Lys Leu Ala Ala Lys 
    530                 535                 540                 


Leu Ser Ala Thr Leu Glu Gln Ala Ala Ala Thr Ala Arg Val Thr Phe 
545                 550                 555                 560 


Ser Gly Leu Arg Asp Thr Val Thr Pro Gly Glu Leu Leu Lys Ala Glu 
                565                 570                 575     


Ile Ile Asp Gln Asp Leu Tyr Glu Arg Leu Glu His Gly Gln Ala Thr 
            580                 585                 590         


Ala Lys Asp Val Gly Ser Leu Ala Ser Val Gln Arg Tyr Leu Gln Gly 
        595                 600                 605             


Thr Gly Cys Ile Ala Gly Leu Leu Leu Pro Gly Ser Gln Glu Arg Leu 
    610                 615                 620                 


Ser Ile Tyr Glu Ala Arg Cys Lys Gly Leu Leu Arg Pro Gly Thr Ala 
625                 630                 635                 640 


Leu Ile Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Ile Ile Asp Pro 
                645                 650                 655     


Lys Ala Asn Lys Gly His Ser Val Glu Glu Ala Leu Arg Ala Ala Val 
            660                 665                 670         


Ile Gly Pro Asp Val Phe Ala Lys Leu Leu Ser Ala Glu Arg Ala Val 
        675                 680                 685             


Thr Gly Tyr Thr Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln 
    690                 695                 700                 


Ala Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu 
705                 710                 715                 720 


Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser His 
                725                 730                 735     


Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp Gln Met 
            740                 745                 750         


Leu Asn Leu Ile Leu Leu Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe 
        755                 760                 765             


Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln Leu Leu Glu Arg 
    770                 775                 780                 


Cys Val Arg Asp Pro Glu Thr Gly Leu Tyr Leu Leu Pro Leu Ser Ser 
785                 790                 795                 800 


Thr Gln Ser Pro Leu Val Asp Ser Ala Thr Gln Gln Ala Phe Gln Asn 
                805                 810                 815     


Leu Leu Leu Ser Val Lys Tyr Gly Arg Phe Gln Gly Gln Arg Val Ser 
            820                 825                 830         


Ala Trp Glu Leu Ile Asn Ser Glu Tyr Phe Ser Glu Gly Arg Arg Arg 
        835                 840                 845             


Gln Leu Leu Arg Arg Tyr Arg Gln Arg Glu Val Thr Leu Gly Gln Val 
    850                 855                 860                 


Ala Lys Leu Leu Glu Ala Glu Thr Gln Arg Gln Ala Asp Ile Met Leu 
865                 870                 875                 880 


Pro Ala Leu Arg Ser Arg Val Thr Val His Gln Leu Leu Glu Ala Gly 
                885                 890                 895     


Ile Ile Asp Gln Gln Leu Leu Asp Gln Val Leu Ala Gly Thr Ile Ser 
            900                 905                 910         


Pro Glu Ala Leu Leu Leu Met Asp Gly Val Arg Arg Tyr Leu Cys Gly 
        915                 920                 925             


Leu Gly Ala Val Gly Gly Val Arg Leu Leu Pro Ser Gly Gln Arg Leu 
    930                 935                 940                 


Ser Leu Tyr Gln Ala Met Arg Gln Lys Leu Leu Gly Pro Arg Val Ala 
945                 950                 955                 960 


Leu Ala Leu Leu Glu Ala Gln Ala Ala Thr Gly Thr Ile Met Asp Pro 
                965                 970                 975     


His Ser Pro Glu Ser Leu Ser Val Asp Glu Ala Val Arg Arg Gly Val 
            980                 985                 990         


Val Gly Pro Glu Leu Tyr Gly Arg  Leu Lys Arg Ala Glu  Gly Ala Ile 
        995                 1000                 1005             


Ala Gly  Phe Arg Asp Pro Phe  Ser Gly Lys Gln Val  Ser Val Phe 
    1010                 1015                 1020             


Gln Ala  Met Lys Lys Gly Leu  Ile Pro Trp Glu Gln  Ala Ala Arg 
    1025                 1030                 1035             


Leu Leu  Glu Ala Gln Val Ala  Thr Gly Gly Ile Ile  Asp Pro Thr 
    1040                 1045                 1050             


Ser His  His His Leu Pro Met  Pro Val Ala Ile Gln  Arg Gly Tyr 
    1055                 1060                 1065             


Val Asp  Gln Glu Met Glu Thr  Ala Leu Ser Ser Ser  Ser Glu Thr 
    1070                 1075                 1080             


Phe Pro  Thr Pro Asp Gly Gln  Gly Arg Thr Ser Tyr  Ala Gln Leu 
    1085                 1090                 1095             


Leu Glu  Glu Cys Pro Arg Asp  Glu Thr Ser Gly Leu  His Leu Leu 
    1100                 1105                 1110             


Pro Leu  Pro Glu Ser Ala Pro  Ala Leu Pro Thr Glu  Glu Gln Val 
    1115                 1120                 1125             


Gln Arg  Ser Leu Gln Ala Val  Pro Gly Ala Lys Asp  Gly Thr Ser 
    1130                 1135                 1140             


Leu Trp  Asp Leu Leu Ser Ser  Cys His Phe Thr Glu  Glu Gln Arg 
    1145                 1150                 1155             


Arg Gly  Leu Leu Glu Asp Val  Gln Glu Gly Arg Thr  Thr Val Pro 
    1160                 1165                 1170             


Gln Leu  Leu Ala Ser Val Gln  Arg Trp Val Gln Glu  Thr Lys Leu 
    1175                 1180                 1185             


Leu Ala  Gln Ala Arg Val Met  Val Pro Gly Pro Arg  Gly Glu Val 
    1190                 1195                 1200             


Pro Ala  Val Trp Leu Leu Asp  Ala Gly Ile Ile Thr  Gln Glu Thr 
    1205                 1210                 1215             


Leu Glu  Ala Leu Ala Gln Gly  Thr Gln Ser Pro Ala  Gln Val Ala 
    1220                 1225                 1230             


Glu Gln  Pro Ala Val Lys Ala  Cys Leu Trp Gly Thr  Gly Cys Val 
    1235                 1240                 1245             


Ala Gly  Val Leu Leu Gln Pro  Ser Gly Ala Lys Ala  Ser Ile Ala 
    1250                 1255                 1260             


Gln Ala  Val Arg Asp Gly Leu  Leu Pro Thr Gly Leu  Gly Gln Arg 
    1265                 1270                 1275             


Leu Leu  Glu Ala Gln Val Ala  Ser Gly Phe Leu Val  Asp Pro Leu 
    1280                 1285                 1290             


Asn Asn  Gln Arg Leu Ser Val  Glu Asp Ala Val Lys  Val Gly Leu 
    1295                 1300                 1305             


Val Gly  Arg Glu Leu Ser Glu  Gln Leu Gly Gln Ala  Glu Arg Ala 
    1310                 1315                 1320             


Ala Ala  Gly Tyr Pro Asp Pro  Tyr Ser Arg Ala Ser  Leu Ser Leu 
    1325                 1330                 1335             


Trp Gln  Ala Met Glu Lys Gly  Leu Val Pro Gln Asn  Glu Gly Leu 
    1340                 1345                 1350             


Pro Leu  Leu Gln Val Gln Leu  Ala Thr Gly Gly Val  Val Asp Pro 
    1355                 1360                 1365             


Val His  Gly Val His Leu Pro  Gln Ala Ala Ala Cys  Arg Leu Gly 
    1370                 1375                 1380             


Leu Leu  Asp Thr Gln Thr Ser  Gln Val Leu Thr Ala  Val Asp Lys 
    1385                 1390                 1395             


Asp Asn  Lys Phe Phe Phe Asp  Pro Ser Ala Arg Asp  Gln Val Thr 
    1400                 1405                 1410             


Tyr Gln  Gln Leu Arg Glu Arg  Cys Val Cys Asp Ser  Glu Thr Gly 
    1415                 1420                 1425             


Leu Leu  Leu Leu Pro Leu Pro  Ser Asp Thr Val Leu  Glu Val Asp 
    1430                 1435                 1440             


Asp His  Thr Ala Val Ala Leu  Arg Ala Met Lys Val  Pro Val Ser 
    1445                 1450                 1455             


Thr Gly  Arg Phe Lys Gly Cys  Ser Val Ser Leu Trp  Asp Leu Leu 
    1460                 1465                 1470             


Leu Ser  Glu Tyr Val Gly Ala  Asp Lys Arg Arg Glu  Leu Val Ala 
    1475                 1480                 1485             


Leu Cys  Arg Ser Gly Arg Ala  Ala Ala Leu Arg Gln  Val Val Ser 
    1490                 1495                 1500             


Ala Val  Thr Thr Leu Val Glu  Ala Ala Glu Arg Gln  Pro Leu Gln 
    1505                 1510                 1515             


Ala Thr  Phe Arg Gly Leu Arg  Lys Gln Val Ser Ala  Arg Asp Leu 
    1520                 1525                 1530             


Phe Arg  Ala Gln Leu Ile Ser  Arg Lys Thr Leu Asp  Glu Leu Ser 
    1535                 1540                 1545             


Gln Gly  Thr Thr Thr Val Lys  Glu Val Ala Glu Met  Asp Ser Val 
    1550                 1555                 1560             


Lys Arg  Ser Leu Glu Gly Gly  Asn Phe Ile Ala Gly  Val Leu Ile 
    1565                 1570                 1575             


Gln Gly  Thr Gln Glu Arg Met  Ser Ile Pro Glu Ala  Leu Arg Arg 
    1580                 1585                 1590             


His Ile  Leu Arg Pro Gly Thr  Ala Leu Val Leu Leu  Glu Ala Gln 
    1595                 1600                 1605             


Ala Ala  Thr Gly Phe Ile Ile  Asp Pro Val Glu Asn  Arg Lys Leu 
    1610                 1615                 1620             


Thr Val  Glu Glu Ala Phe Lys  Ala Gly Met Phe Gly  Lys Glu Thr 
    1625                 1630                 1635             


Tyr Val  Lys Leu Leu Ser Ala  Glu Arg Ala Val Thr  Gly Tyr Thr 
    1640                 1645                 1650             


Asp Pro  Tyr Thr Gly Gln Gln  Ile Ser Leu Phe Gln  Ala Met Gln 
    1655                 1660                 1665             


Lys Asp  Leu Ile Val Arg Glu  His Gly Ile Arg Leu  Leu Glu Ala 
    1670                 1675                 1680             


Gln Ile  Ala Thr Gly Gly Ile  Ile Asp Pro Val His  Ser His Arg 
    1685                 1690                 1695             


Val Pro  Val Asp Val Ala Tyr  Arg Cys Gly Tyr Phe  Asp Glu Glu 
    1700                 1705                 1710             


Met Asn  Arg Ile Leu Ala Asp  Pro Ser Asp Asp Thr  Lys Gly Phe 
    1715                 1720                 1725             


Phe Asp  Pro Asn Thr His Glu  Asn Leu Thr Tyr Leu  Gln Leu Leu 
    1730                 1735                 1740             


Glu Arg  Cys Val Glu Asp Pro  Glu Thr Gly Leu Tyr  Leu Leu Gln 
    1745                 1750                 1755             


Ile Ile  Lys Lys Gly Glu Asn  Tyr Val Tyr Ile Asn  Glu Ala Thr 
    1760                 1765                 1770             


Arg His  Val Leu Gln Ser Arg  Thr Ala Lys Met Arg  Val Gly Arg 
    1775                 1780                 1785             


Phe Ala  Asp Gln Val Val Ser  Phe Trp Asp Leu Leu  Ser Ser Pro 
    1790                 1795                 1800             


Tyr Phe  Thr Glu Asp Arg Lys  Arg Glu Leu Ile Gln  Glu Tyr Gly 
    1805                 1810                 1815             


Ala Gln  Ser Gly Gly Leu Glu  Lys Leu Leu Glu Ile  Ile Thr Thr 
    1820                 1825                 1830             


Thr Ile  Glu Glu Thr Glu Thr  Gln Asn Gln Gly Ile  Lys Val Ala 
    1835                 1840                 1845             


Ala Ile  Arg Gly Glu Val Thr  Ala Ala Asp Leu Phe  Asn Ser Arg 
    1850                 1855                 1860             


Val Ile  Asp Gln Lys Thr Leu  His Thr Leu Arg Val  Gly Arg Thr 
    1865                 1870                 1875             


Gly Gly  Gln Ala Leu Ser Thr  Leu Glu Cys Val Lys  Pro Tyr Leu 
    1880                 1885                 1890             


Glu Gly  Ser Gly Cys Ile Ala  Gly Val Thr Val Pro  Ser Thr Arg 
    1895                 1900                 1905             


Glu Val  Met Ser Leu His Glu  Ala Ser Arg Lys Glu  Leu Ile Pro 
    1910                 1915                 1920             


Ala Ala  Phe Ala Thr Trp Leu  Leu Glu Ala Gln Ala  Ala Thr Gly 
    1925                 1930                 1935             


Phe Leu  Leu Asp Pro Cys Thr  Arg Gln Lys Leu Ser  Val Asp Glu 
    1940                 1945                 1950             


Ala Val  Asp Val Gly Leu Val  Asn Glu Glu Leu Arg  Glu Arg Leu 
    1955                 1960                 1965             


Leu Lys  Ala Glu Arg Ala Ala  Thr Gly Tyr Arg Asp  Pro Ala Thr 
    1970                 1975                 1980             


Gly Asp  Thr Ile Pro Leu Phe  Gln Ala Met Gln Lys  Gln Leu Ile 
    1985                 1990                 1995             


Glu Lys  Ala Glu Ala Leu Arg  Leu Leu Glu Val Gln  Val Ala Thr 
    2000                 2005                 2010             


Gly Gly  Val Ile Asp Pro Gln  His His His Arg Leu  Pro Leu Glu 
    2015                 2020                 2025             


Thr Ala  Tyr Arg Arg Gly Cys  Leu His Lys Asp Ile  Tyr Ala Leu 
    2030                 2035                 2040             


Ile Ser  Asp Gln Lys His Met  Arg Lys Arg Phe Val  Asp Pro Asn 
    2045                 2050                 2055             


Thr Gln  Glu Lys Val Ser Tyr  Arg Glu Leu Gln Glu  Arg Cys Arg 
    2060                 2065                 2070             


Pro Gln  Glu Asp Thr Gly Trp  Leu Leu Phe Pro Val  Asn Lys Ala 
    2075                 2080                 2085             


Ala Arg  Asp Ser Glu His Ile  Asp Asp Glu Thr Arg  Arg Ala Leu 
    2090                 2095                 2100             


Glu Ala  Glu Gln Val Glu Ile  Thr Val Gly Arg Phe  Arg Gly Gln 
    2105                 2110                 2115             


Lys Pro  Thr Leu Trp Ala Leu  Leu Asn Ser Glu Tyr  Val Thr Glu 
    2120                 2125                 2130             


Glu Lys  Lys Leu Gln Leu Val  Arg Met Tyr Arg Thr  His Thr Arg 
    2135                 2140                 2145             


Arg Ala  Leu Gln Thr Val Ala  Gln Leu Ile Leu Glu  Leu Ile Glu 
    2150                 2155                 2160             


Lys Gln  Glu Thr Ser Asn Lys  His Leu Trp Phe Gln  Gly Ile Arg 
    2165                 2170                 2175             


Arg Gln  Ile Thr Ala Ser Glu  Leu Leu Ser Ser Ala  Ile Ile Thr 
    2180                 2185                 2190             


Glu Glu  Met Leu Gln Asp Leu  Glu Thr Gly Arg Ser  Thr Thr Gln 
    2195                 2200                 2205             


Glu Leu  Met Glu Asp Asp Arg  Val Lys Arg Tyr Leu  Glu Gly Thr 
    2210                 2215                 2220             


Ser Cys  Ile Ala Gly Val Leu  Val Pro Ala Lys Asp  Gln Pro Gly 
    2225                 2230                 2235             


Arg Gln  Glu Lys Met Ser Ile  Tyr Gln Ala Met Trp  Lys Gly Val 
    2240                 2245                 2250             


Leu Arg  Pro Gly Thr Ala Leu  Val Leu Leu Glu Ala  Gln Ala Ala 
    2255                 2260                 2265             


Thr Gly  Phe Val Ile Asp Pro  Val Arg Asn Leu Arg  Leu Ser Val 
    2270                 2275                 2280             


Glu Glu  Ala Val Ala Ala Gly  Val Val Gly Gly Glu  Ile Gln Glu 
    2285                 2290                 2295             


Lys Leu  Leu Ser Ala Glu Arg  Ala Val Thr Gly Tyr  Thr Asp Pro 
    2300                 2305                 2310             


Tyr Thr  Gly Gln Gln Ile Ser  Leu Phe Gln Ala Met  Gln Lys Asp 
    2315                 2320                 2325             


Leu Ile  Val Arg Glu His Gly  Ile Arg Leu Leu Glu  Ala Gln Ile 
    2330                 2335                 2340             


Ala Thr  Gly Gly Val Ile Asp  Pro Val His Ser His  Arg Val Pro 
    2345                 2350                 2355             


Val Asp  Val Ala Tyr Arg Arg  Gly Tyr Phe Asp Glu  Glu Met Asn 
    2360                 2365                 2370             


Arg Val  Leu Ala Asp Pro Ser  Asp Asp Thr Lys Gly  Phe Phe Asp 
    2375                 2380                 2385             


Pro Asn  Thr His Glu Asn Leu  Thr Tyr Val Gln Leu  Leu Arg Arg 
    2390                 2395                 2400             


Cys Val  Pro Asp Pro Asp Thr  Gly Leu Tyr Met Leu  Gln Leu Ala 
    2405                 2410                 2415             


Gly Arg  Gly Ser Ala Val His  Gln Leu Ser Glu Glu  Leu Arg Cys 
    2420                 2425                 2430             


Ala Leu  Arg Asp Ala Arg Val  Thr Pro Gly Ser Gly  Ala Leu Gln 
    2435                 2440                 2445             


Gly Gln  Ser Val Ser Val Trp  Glu Leu Leu Phe Tyr  Arg Glu Val 
    2450                 2455                 2460             


Ser Glu  Asp Arg Arg Gln Asp  Leu Leu Ser Arg Tyr  Arg Ala Gly 
    2465                 2470                 2475             


Thr Leu  Thr Val Glu Glu Leu  Gly Ala Thr Leu Thr  Ser Leu Leu 
    2480                 2485                 2490             


Ala Gln  Ala Gln Ala Gln Ala  Arg Ala Glu Ala Glu  Ala Gly Ser 
    2495                 2500                 2505             


Pro Arg  Pro Asp Pro Arg Glu  Ala Leu Arg Ala Ala  Thr Met Glu 
    2510                 2515                 2520             


Val Lys  Val Gly Arg Leu Arg  Gly Arg Ala Val Pro  Val Trp Asp 
    2525                 2530                 2535             


Val Leu  Ala Ser Gly Tyr Val  Ser Arg Ala Ala Arg  Glu Glu Leu 
    2540                 2545                 2550             


Leu Ala  Glu Phe Gly Ser Gly  Thr Leu Asp Leu Pro  Ala Leu Thr 
    2555                 2560                 2565             


Arg Arg  Leu Thr Ala Ile Ile  Glu Glu Ala Glu Glu  Ala Pro Gly 
    2570                 2575                 2580             


Ala Arg  Pro Gln Leu Gln Asp  Ala Trp Arg Gly Pro  Arg Glu Pro 
    2585                 2590                 2595             


Gly Pro  Ala Gly Arg Gly Asp  Gly Asp Ser Gly Arg  Ser Gln Arg 
    2600                 2605                 2610             


Glu Gly  Gln Gly Glu Gly Glu  Thr Gln Glu Ala Ala  Ala Ala Ala 
    2615                 2620                 2625             


Ala Ala  Ala Ala Ala Arg Arg  Gln Glu Gln Thr Leu  Arg Asp Ala 
    2630                 2635                 2640             


Thr Met  Glu Val Gln Arg Gly  Gln Phe Gln Gly Arg  Pro Val Ser 
    2645                 2650                 2655             


Val Trp  Asp Val Leu Phe Ser  Ser Tyr Leu Ser Glu  Ala Arg Arg 
    2660                 2665                 2670             


Asp Glu  Leu Leu Ala Gln His  Ala Ala Gly Ala Leu  Gly Leu Pro 
    2675                 2680                 2685             


Asp Leu  Val Ala Val Leu Thr  Arg Val Ile Glu Glu  Thr Glu Glu 
    2690                 2695                 2700             


Arg Leu  Ser Lys Val Ser Phe  Arg Gly Leu Arg Arg  Gln Val Ser 
    2705                 2710                 2715             


Ala Ser  Glu Leu His Thr Ser  Gly Ile Leu Gly Pro  Glu Thr Leu 
    2720                 2725                 2730             


Arg Asp  Leu Ala Gln Gly Thr  Lys Thr Leu Gln Glu  Val Thr Glu 
    2735                 2740                 2745             


Met Asp  Ser Val Lys Arg Tyr  Leu Glu Gly Thr Ser  Cys Ile Ala 
    2750                 2755                 2760             


Gly Val  Leu Val Pro Ala Lys  Asp Gln Pro Gly Arg  Gln Glu Lys 
    2765                 2770                 2775             


Met Ser  Ile Tyr Gln Ala Met  Trp Lys Gly Val Leu  Arg Pro Gly 
    2780                 2785                 2790             


Thr Ala  Leu Val Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Phe Val 
    2795                 2800                 2805             


Ile Asp  Pro Val Arg Asn Leu  Arg Leu Ser Val Glu  Glu Ala Val 
    2810                 2815                 2820             


Ala Ala  Gly Val Val Gly Gly  Glu Ile Gln Glu Lys  Leu Leu Ser 
    2825                 2830                 2835             


Ala Glu  Arg Ala Val Thr Gly  Tyr Thr Asp Pro Tyr  Thr Gly Gln 
    2840                 2845                 2850             


Gln Ile  Ser Leu Phe Gln Ala  Met Gln Lys Asp Leu  Ile Val Arg 
    2855                 2860                 2865             


Glu His  Gly Ile Arg Leu Leu  Glu Ala Gln Ile Ala  Thr Gly Gly 
    2870                 2875                 2880             


Val Ile  Asp Pro Val His Ser  His Arg Val Pro Val  Asp Val Ala 
    2885                 2890                 2895             


Tyr Gln  Arg Gly Tyr Phe Asp  Glu Glu Met Asn Arg  Val Leu Ala 
    2900                 2905                 2910             


Asp Pro  Ser Asp Asp Thr Lys  Gly Phe Phe Asp Pro  Asn Thr His 
    2915                 2920                 2925             


Glu Asn  Leu Thr Tyr Val Gln  Leu Leu Arg Arg Cys  Val Pro Asp 
    2930                 2935                 2940             


Pro Asp  Thr Gly Leu Tyr Met  Leu Gln Leu Ala Gly  Arg Gly Ser 
    2945                 2950                 2955             


Ala Val  His Gln Leu Ser Glu  Glu Leu Arg Cys Ala  Leu Arg Asp 
    2960                 2965                 2970             


Ala Arg  Val Thr Pro Gly Ser  Gly Ala Leu Gln Gly  Gln Ser Val 
    2975                 2980                 2985             


Ser Val  Trp Glu Leu Leu Phe  Tyr Arg Glu Val Ser  Glu Asp Arg 
    2990                 2995                 3000             


Arg Gln  Asp Leu Leu Ser Arg  Tyr Arg Ala Gly Thr  Leu Thr Val 
    3005                 3010                 3015             


Glu Glu  Leu Gly Ala Thr Leu  Thr Ser Leu Leu Ala  Gln Ala Gln 
    3020                 3025                 3030             


Ala Gln  Ala Arg Ala Glu Ala  Glu Ala Gly Ser Pro  Arg Pro Asp 
    3035                 3040                 3045             


Pro Arg  Glu Ala Leu Arg Ala  Ala Thr Met Glu Val  Lys Val Gly 
    3050                 3055                 3060             


Arg Leu  Arg Gly Arg Ala Val  Pro Val Trp Asp Val  Leu Ala Ser 
    3065                 3070                 3075             


Gly Tyr  Val Ser Arg Ala Ala  Arg Glu Glu Leu Leu  Ala Glu Phe 
    3080                 3085                 3090             


Gly Ser  Gly Thr Leu Asp Leu  Pro Ala Leu Thr Arg  Arg Leu Thr 
    3095                 3100                 3105             


Ala Ile  Ile Glu Glu Ala Glu  Glu Ala Pro Gly Ala  Arg Pro Gln 
    3110                 3115                 3120             


Leu Gln  Asp Ala Trp Arg Gly  Pro Arg Glu Pro Gly  Pro Ala Gly 
    3125                 3130                 3135             


Arg Gly  Asp Gly Asp Ser Gly  Arg Ser Gln Arg Glu  Gly Gln Gly 
    3140                 3145                 3150             


Glu Gly  Glu Thr Gln Glu Ala  Ala Ala Ala Ala Arg  Arg Gln Glu 
    3155                 3160                 3165             


Gln Thr  Leu Arg Asp Ala Thr  Met Glu Val Gln Arg  Gly Gln Phe 
    3170                 3175                 3180             


Gln Gly  Arg Pro Val Ser Val  Trp Asp Val Leu Phe  Ser Ser Tyr 
    3185                 3190                 3195             


Leu Ser  Glu Ala Arg Arg Asp  Glu Leu Leu Ala Gln  His Ala Ala 
    3200                 3205                 3210             


Gly Ala  Leu Gly Leu Pro Asp  Leu Val Ala Val Leu  Thr Arg Val 
    3215                 3220                 3225             


Ile Glu  Glu Thr Glu Glu Arg  Leu Ser Lys Val Ser  Phe Arg Gly 
    3230                 3235                 3240             


Leu Arg  Cys Gln Val Ser Ala  Ser Glu Leu His Thr  Ser Gly Ile 
    3245                 3250                 3255             


Leu Gly  Pro Glu Thr Leu Arg  Asp Leu Ala Gln Gly  Thr Lys Thr 
    3260                 3265                 3270             


Leu Gln  Glu Val Thr Glu Met  Asp Ser Val Lys Arg  Tyr Leu Glu 
    3275                 3280                 3285             


Gly Thr  Ser Cys Ile Ala Gly  Val Leu Val Pro Ala  Lys Asp Gln 
    3290                 3295                 3300             


Pro Gly  Arg Gln Glu Lys Met  Ser Ile Tyr Gln Ala  Met Trp Lys 
    3305                 3310                 3315             


Gly Val  Leu Arg Pro Gly Thr  Ala Leu Val Leu Leu  Glu Ala Gln 
    3320                 3325                 3330             


Ala Ala  Thr Gly Phe Val Ile  Asp Pro Val Arg Asn  Leu Arg Leu 
    3335                 3340                 3345             


Ser Val  Glu Glu Ala Val Ala  Ala Gly Val Val Gly  Gly Glu Ile 
    3350                 3355                 3360             


Gln Glu  Lys Leu Leu Ser Ala  Glu Arg Ala Val Thr  Gly Tyr Thr 
    3365                 3370                 3375             


Asp Pro  Tyr Thr Gly Gln Gln  Ile Ser Leu Phe Gln  Ala Met Gln 
    3380                 3385                 3390             


Lys Asp  Leu Ile Val Arg Glu  His Gly Ile Arg Leu  Leu Glu Ala 
    3395                 3400                 3405             


Gln Ile  Ala Thr Gly Gly Val  Ile Asp Pro Val His  Ser His Arg 
    3410                 3415                 3420             


Val Pro  Val Asp Val Ala Tyr  Arg Arg Gly Tyr Phe  Asp Glu Glu 
    3425                 3430                 3435             


Met Asn  Arg Val Leu Ala Asp  Pro Ser Asp Asp Thr  Lys Gly Phe 
    3440                 3445                 3450             


Phe Asp  Pro Asn Thr His Glu  Asn Leu Thr Tyr Val  Gln Leu Leu 
    3455                 3460                 3465             


Arg Arg  Cys Val Pro Asp Pro  Asp Thr Gly Leu Tyr  Met Leu Gln 
    3470                 3475                 3480             


Leu Ala  Gly Arg Gly Ser Ala  Val His Gln Leu Ser  Glu Glu Leu 
    3485                 3490                 3495             


Arg Cys  Ala Leu Arg Asp Ala  Arg Val Thr Pro Gly  Ser Gly Ala 
    3500                 3505                 3510             


Leu Gln  Gly Gln Ser Val Ser  Val Trp Glu Leu Leu  Phe Tyr Arg 
    3515                 3520                 3525             


Glu Val  Ser Glu Asp Arg Arg  Gln Asp Leu Leu Ser  Arg Tyr Arg 
    3530                 3535                 3540             


Ala Gly  Thr Leu Thr Val Glu  Glu Leu Gly Ala Thr  Leu Thr Ser 
    3545                 3550                 3555             


Leu Leu  Ala Gln Ala Gln Ala  Gln Ala Arg Ala Glu  Ala Glu Ala 
    3560                 3565                 3570             


Gly Ser  Pro Arg Pro Asp Pro  Arg Glu Ala Leu Arg  Ala Ala Thr 
    3575                 3580                 3585             


Met Glu  Val Lys Val Gly Arg  Leu Arg Gly Arg Ala  Val Pro Val 
    3590                 3595                 3600             


Trp Asp  Val Leu Ala Ser Gly  Tyr Val Ser Arg Ala  Ala Arg Glu 
    3605                 3610                 3615             


Glu Leu  Leu Ala Glu Phe Gly  Ser Gly Thr Leu Asp  Leu Pro Ala 
    3620                 3625                 3630             


Leu Thr  Arg Arg Leu Thr Ala  Ile Ile Glu Glu Ala  Glu Glu Ala 
    3635                 3640                 3645             


Pro Gly  Ala Arg Pro Gln Leu  Gln Asp Ala Trp Arg  Gly Pro Arg 
    3650                 3655                 3660             


Glu Pro  Gly Pro Ala Gly Arg  Gly Asp Gly Asp Ser  Gly Arg Ser 
    3665                 3670                 3675             


Gln Arg  Glu Gly Gln Gly Glu  Gly Glu Thr Gln Glu  Ala Ala Ala 
    3680                 3685                 3690             


Ala Thr  Ala Ala Ala Arg Arg  Gln Glu Gln Thr Leu  Arg Asp Ala 
    3695                 3700                 3705             


Thr Met  Glu Val Gln Arg Gly  Gln Phe Gln Gly Arg  Pro Val Ser 
    3710                 3715                 3720             


Val Trp  Asp Val Leu Phe Ser  Ser Tyr Leu Ser Glu  Ala Arg Arg 
    3725                 3730                 3735             


Asp Glu  Leu Leu Ala Gln His  Ala Ala Gly Ala Leu  Gly Leu Pro 
    3740                 3745                 3750             


Asp Leu  Val Ala Val Leu Thr  Arg Val Ile Glu Glu  Thr Glu Glu 
    3755                 3760                 3765             


Arg Leu  Ser Lys Val Ser Phe  Arg Gly Leu Arg Arg  Gln Val Ser 
    3770                 3775                 3780             


Ala Ser  Glu Leu His Thr Ser  Gly Ile Leu Gly Pro  Glu Thr Leu 
    3785                 3790                 3795             


Arg Asp  Leu Ala Gln Gly Thr  Lys Thr Leu Gln Glu  Val Thr Glu 
    3800                 3805                 3810             


Met Asp  Ser Val Lys Arg Tyr  Leu Glu Gly Thr Ser  Cys Ile Ala 
    3815                 3820                 3825             


Gly Val  Leu Val Pro Ala Lys  Asp Gln Pro Gly Arg  Gln Glu Lys 
    3830                 3835                 3840             


Met Ser  Ile Tyr Gln Ala Met  Trp Lys Gly Val Leu  Arg Pro Gly 
    3845                 3850                 3855             


Thr Ala  Leu Val Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Phe Val 
    3860                 3865                 3870             


Ile Asp  Pro Val Arg Asn Leu  Arg Leu Ser Val Glu  Glu Ala Val 
    3875                 3880                 3885             


Ala Ala  Gly Val Val Gly Gly  Glu Ile Gln Glu Lys  Leu Leu Ser 
    3890                 3895                 3900             


Ala Glu  Arg Ala Val Thr Gly  Tyr Thr Asp Pro Tyr  Thr Gly Gln 
    3905                 3910                 3915             


Gln Ile  Ser Leu Phe Gln Ala  Met Gln Lys Asp Leu  Ile Val Arg 
    3920                 3925                 3930             


Glu His  Gly Ile Arg Leu Leu  Glu Ala Gln Ile Ala  Thr Gly Gly 
    3935                 3940                 3945             


Val Ile  Asp Pro Val His Ser  His Arg Val Pro Val  Asp Val Ala 
    3950                 3955                 3960             


Tyr Arg  Arg Gly Tyr Phe Asp  Glu Glu Met Asn Arg  Val Leu Ala 
    3965                 3970                 3975             


Asp Pro  Ser Asp Asp Thr Lys  Gly Phe Phe Asp Pro  Asn Thr His 
    3980                 3985                 3990             


Glu Asn  Leu Thr Tyr Val Gln  Leu Leu Arg Arg Cys  Val Pro Asp 
    3995                 4000                 4005             


Pro Asp  Thr Gly Leu Tyr Met  Leu Gln Leu Ala Gly  Arg Gly Ser 
    4010                 4015                 4020             


Ala Val  His Gln Leu Ser Glu  Glu Leu Arg Cys Ala  Leu Arg Asp 
    4025                 4030                 4035             


Ala Arg  Val Thr Pro Gly Ser  Gly Ala Leu Gln Gly  Gln Ser Val 
    4040                 4045                 4050             


Ser Val  Trp Glu Leu Leu Phe  Tyr Arg Glu Val Ser  Glu Asp Arg 
    4055                 4060                 4065             


Arg Gln  Asp Leu Leu Ser Arg  Tyr Arg Ala Gly Thr  Leu Thr Val 
    4070                 4075                 4080             


Glu Glu  Leu Gly Ala Thr Leu  Thr Ser Leu Leu Ala  Gln Ala Gln 
    4085                 4090                 4095             


Ala Gln  Ala Arg Ala Glu Ala  Glu Ala Gly Ser Pro  Arg Pro Asp 
    4100                 4105                 4110             


Pro Arg  Glu Ala Leu Arg Ala  Ala Thr Met Glu Val  Lys Val Gly 
    4115                 4120                 4125             


Arg Leu  Arg Gly Arg Ala Val  Pro Val Trp Asp Val  Leu Ala Ser 
    4130                 4135                 4140             


Gly Tyr  Val Ser Arg Ala Ala  Arg Glu Glu Leu Leu  Ala Glu Phe 
    4145                 4150                 4155             


Gly Ser  Gly Thr Leu Asp Leu  Pro Ala Leu Thr Arg  Arg Leu Thr 
    4160                 4165                 4170             


Ala Ile  Ile Glu Glu Ala Glu  Glu Ala Pro Gly Ala  Arg Pro Gln 
    4175                 4180                 4185             


Leu Gln  Asp Ala Trp Arg Gly  Pro Arg Glu Pro Gly  Pro Ala Gly 
    4190                 4195                 4200             


Arg Gly  Asp Gly Asp Ser Gly  Arg Ser Gln Arg Glu  Gly Gln Gly 
    4205                 4210                 4215             


Glu Gly  Glu Thr Gln Glu Ala  Ala Ala Ala Thr Ala  Ala Ala Arg 
    4220                 4225                 4230             


Arg Gln  Glu Gln Thr Leu Arg  Asp Ala Thr Met Glu  Val Gln Arg 
    4235                 4240                 4245             


Gly Gln  Phe Gln Gly Arg Pro  Val Ser Val Trp Asp  Val Leu Phe 
    4250                 4255                 4260             


Ser Ser  Tyr Leu Ser Glu Ala  Arg Arg Asp Glu Leu  Leu Ala Gln 
    4265                 4270                 4275             


His Ala  Ala Gly Ala Leu Gly  Leu Pro Asp Leu Val  Ala Val Leu 
    4280                 4285                 4290             


Thr Arg  Val Ile Glu Glu Thr  Glu Glu Arg Leu Ser  Lys Val Ser 
    4295                 4300                 4305             


Phe Arg  Gly Leu Arg Arg Gln  Val Ser Ala Ser Glu  Leu His Thr 
    4310                 4315                 4320             


Ser Gly  Ile Leu Gly Pro Glu  Thr Leu Arg Asp Leu  Ala Gln Gly 
    4325                 4330                 4335             


Thr Lys  Thr Leu Gln Glu Val  Thr Glu Met Asp Ser  Val Lys Arg 
    4340                 4345                 4350             


Tyr Leu  Glu Gly Thr Ser Cys  Ile Ala Gly Val Leu  Val Pro Ala 
    4355                 4360                 4365             


Lys Asp  Gln Pro Gly His Gln  Glu Lys Met Ser Ile  Tyr Gln Ala 
    4370                 4375                 4380             


Met Trp  Lys Gly Val Leu Arg  Pro Gly Thr Ala Leu  Val Leu Leu 
    4385                 4390                 4395             


Glu Ala  Gln Ala Ala Thr Gly  Phe Val Ile Asp Pro  Val Arg Asn 
    4400                 4405                 4410             


Leu Arg  Leu Ser Val Glu Glu  Ala Val Ala Ala Gly  Val Val Gly 
    4415                 4420                 4425             


Gly Glu  Ile Gln Glu Lys Leu  Leu Ser Ala Glu Arg  Ala Val Thr 
    4430                 4435                 4440             


Gly Tyr  Thr Asp Pro Tyr Thr  Gly Gln Gln Ile Ser  Leu Phe Gln 
    4445                 4450                 4455             


Ala Met  Gln Lys Asp Leu Ile  Val Arg Glu His Gly  Ile Arg Leu 
    4460                 4465                 4470             


Leu Glu  Ala Gln Ile Ala Thr  Gly Gly Val Ile Asp  Pro Val His 
    4475                 4480                 4485             


Ser His  Arg Val Pro Val Asp  Val Ala Tyr Arg Arg  Gly Tyr Phe 
    4490                 4495                 4500             


Asp Glu  Glu Met Asn Arg Val  Leu Ala His Pro Ser  Asp Asp Thr 
    4505                 4510                 4515             


Lys Gly  Phe Phe Asp Pro Asn  Thr His Glu Asn Leu  Thr Tyr Val 
    4520                 4525                 4530             


Gln Leu  Leu Arg Arg Cys Val  Pro Asp Pro Asp Thr  Gly Leu Tyr 
    4535                 4540                 4545             


Met Leu  Gln Leu Ala Gly Arg  Gly Ser Ala Val His  Gln Leu Ser 
    4550                 4555                 4560             


Glu Glu  Leu Arg Cys Ala Leu  Arg Asp Ala Arg Val  Met Pro Gly 
    4565                 4570                 4575             


Ser Gly  Ala Leu Gln Gly Gln  Ser Val Ser Val Trp  Glu Leu Leu 
    4580                 4585                 4590             


Phe Tyr  Arg Glu Val Ser Glu  Asp Arg Arg Gln Asp  Leu Leu Ser 
    4595                 4600                 4605             


Arg Tyr  Arg Ala Gly Thr Leu  Thr Val Glu Glu Leu  Gly Ala Thr 
    4610                 4615                 4620             


Leu Thr  Ser Leu Leu Ala Gln  Ala Gln Ala Gln Ala  Arg Ala Glu 
    4625                 4630                 4635             


Ala Glu  Ala Glu Ala Gly Ser  Pro Arg Pro Asp Pro  Arg Glu Ala 
    4640                 4645                 4650             


Leu Arg  Ala Ala Thr Met Glu  Val Lys Val Gly Arg  Leu Arg Gly 
    4655                 4660                 4665             


Arg Ala  Val Pro Val Trp Asp  Val Leu Ala Ser Gly  Tyr Val Ser 
    4670                 4675                 4680             


Gly Ala  Ala Arg Glu Glu Leu  Leu Ala Glu Phe Gly  Ser Gly Thr 
    4685                 4690                 4695             


Leu Asp  Leu Pro Ala Leu Thr  Arg Arg Leu Thr Ala  Ile Ile Glu 
    4700                 4705                 4710             


Glu Ala  Glu Glu Ala Pro Gly  Ala Arg Pro Gln Leu  Gln Asp Ala 
    4715                 4720                 4725             


Trp Arg  Gly Pro Arg Glu Pro  Gly Pro Ala Gly Arg  Gly Asp Gly 
    4730                 4735                 4740             


Asp Ser  Gly Arg Ser Gln Arg  Glu Gly Gln Gly Glu  Gly Glu Thr 
    4745                 4750                 4755             


Gln Glu  Ala Ala Ala Ala Ala  Arg Arg Gln Glu Gln  Thr Leu Arg 
    4760                 4765                 4770             


Asp Ala  Thr Met Glu Val Gln  Arg Gly Gln Phe Gln  Gly Arg Pro 
    4775                 4780                 4785             


Val Ser  Val Trp Asp Val Leu  Phe Ser Ser Tyr Leu  Ser Glu Ala 
    4790                 4795                 4800             


His Arg  Asp Glu Leu Leu Ala  Gln His Ala Ala Gly  Ala Leu Gly 
    4805                 4810                 4815             


Leu Pro  Asp Leu Val Ala Val  Leu Thr Arg Val Ile  Glu Glu Thr 
    4820                 4825                 4830             


Glu Glu  Arg Leu Ser Lys Val  Ser Phe Arg Gly Leu  Arg Arg Gln 
    4835                 4840                 4845             


Val Ser  Ala Ser Glu Leu His  Thr Ser Gly Ile Leu  Gly Pro Glu 
    4850                 4855                 4860             


Thr Leu  Arg Asp Leu Ala Gln  Gly Thr Lys Thr Leu  Gln Glu Val 
    4865                 4870                 4875             


Thr Glu  Met Asp Ser Val Lys  Arg Tyr Leu Glu Gly  Thr Ser Cys 
    4880                 4885                 4890             


Ile Ala  Gly Val Leu Val Pro  Ala Lys Asp Gln Pro  Gly Arg Gln 
    4895                 4900                 4905             


Glu Lys  Met Ser Ile Tyr Gln  Ala Met Trp Lys Gly  Val Leu Arg 
    4910                 4915                 4920             


Pro Gly  Thr Ala Leu Val Leu  Leu Glu Ala Gln Ala  Ala Thr Gly 
    4925                 4930                 4935             


Phe Val  Ile Asp Pro Val Arg  Asn Leu Arg Leu Ser  Val Glu Glu 
    4940                 4945                 4950             


Ala Val  Ala Ala Gly Val Val  Gly Gly Glu Ile Gln  Glu Lys Leu 
    4955                 4960                 4965             


Leu Ser  Ala Glu Arg Ala Val  Thr Gly Tyr Thr Asp  Pro Tyr Thr 
    4970                 4975                 4980             


Gly Gln  Gln Ile Ser Leu Phe  Gln Ala Met Gln Lys  Asp Leu Ile 
    4985                 4990                 4995             


Val Arg  Glu His Gly Ile Arg  Leu Leu Glu Ala Gln  Ile Ala Thr 
    5000                 5005                 5010             


Gly Gly  Val Ile Asp Pro Val  His Ser His Arg Val  Pro Val Asp 
    5015                 5020                 5025             


Val Ala  Tyr Arg Arg Gly Tyr  Phe Asp Glu Glu Met  Asn Arg Val 
    5030                 5035                 5040             


Leu Ala  Asp Pro Ser Asp Asp  Thr Lys Gly Phe Phe  Asp Pro Asn 
    5045                 5050                 5055             


Thr His  Glu Asn Leu Thr Tyr  Leu Gln Leu Leu Gln  Arg Ala Thr 
    5060                 5065                 5070             


Leu Asp  Pro Glu Thr Gly Leu  Leu Phe Leu Ser Leu  Ser Leu Gln 
    5075                 5080                 5085             


<210>  3616
<211>  1512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPRS__Homo_sapiens__NP_004437

<400>  3616

Met Ala Thr Leu Ser Leu Thr Val Asn Ser Gly Asp Pro Pro Leu Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Glu His Val Lys Asp Asp Val Ser Ile Ser Val 
            20                  25                  30          


Glu Glu Gly Lys Glu Asn Ile Leu His Val Ser Glu Asn Val Ile Phe 
        35                  40                  45              


Thr Asp Val Asn Ser Ile Leu Arg Tyr Leu Ala Arg Val Ala Thr Thr 
    50                  55                  60                  


Ala Gly Leu Tyr Gly Ser Asn Leu Met Glu His Thr Glu Ile Asp His 
65                  70                  75                  80  


Trp Leu Glu Phe Ser Ala Thr Lys Leu Ser Ser Cys Asp Ser Phe Thr 
                85                  90                  95      


Ser Thr Ile Asn Glu Leu Asn His Cys Leu Ser Leu Arg Thr Tyr Leu 
            100                 105                 110         


Val Gly Asn Ser Leu Ser Leu Ala Asp Leu Cys Val Trp Ala Thr Leu 
        115                 120                 125             


Lys Gly Asn Ala Ala Trp Gln Glu Gln Leu Lys Gln Lys Lys Ala Pro 
    130                 135                 140                 


Val His Val Lys Arg Trp Phe Gly Phe Leu Glu Ala Gln Gln Ala Phe 
145                 150                 155                 160 


Gln Ser Val Gly Thr Lys Trp Asp Val Ser Thr Thr Lys Ala Arg Val 
                165                 170                 175     


Ala Pro Glu Lys Lys Gln Asp Val Gly Lys Phe Val Glu Leu Pro Gly 
            180                 185                 190         


Ala Glu Met Gly Lys Val Thr Val Arg Phe Pro Pro Glu Ala Ser Gly 
        195                 200                 205             


Tyr Leu His Ile Gly His Ala Lys Ala Ala Leu Leu Asn Gln His Tyr 
    210                 215                 220                 


Gln Val Asn Phe Lys Gly Lys Leu Ile Met Arg Phe Asp Asp Thr Asn 
225                 230                 235                 240 


Pro Glu Lys Glu Lys Glu Asp Phe Glu Lys Val Ile Leu Glu Asp Val 
                245                 250                 255     


Ala Met Leu His Ile Lys Pro Asp Gln Phe Thr Tyr Thr Ser Asp His 
            260                 265                 270         


Phe Glu Thr Ile Met Lys Tyr Ala Glu Lys Leu Ile Gln Glu Gly Lys 
        275                 280                 285             


Ala Tyr Val Asp Asp Thr Pro Ala Glu Gln Met Lys Ala Glu Arg Glu 
    290                 295                 300                 


Gln Arg Ile Asp Ser Lys His Arg Lys Asn Pro Ile Glu Lys Asn Leu 
305                 310                 315                 320 


Gln Met Trp Glu Glu Met Lys Lys Gly Ser Gln Phe Gly Gln Ser Cys 
                325                 330                 335     


Cys Leu Arg Ala Lys Ile Asp Met Ser Ser Asn Asn Gly Cys Met Arg 
            340                 345                 350         


Asp Pro Thr Leu Tyr Arg Cys Lys Ile Gln Pro His Pro Arg Thr Gly 
        355                 360                 365             


Asn Lys Tyr Asn Val Tyr Pro Thr Tyr Asp Phe Ala Cys Pro Ile Val 
    370                 375                 380                 


Asp Ser Ile Glu Gly Val Thr His Ala Leu Arg Thr Thr Glu Tyr His 
385                 390                 395                 400 


Asp Arg Asp Glu Gln Phe Tyr Trp Ile Ile Glu Ala Leu Gly Ile Arg 
                405                 410                 415     


Lys Pro Tyr Ile Trp Glu Tyr Ser Arg Leu Asn Leu Asn Asn Thr Val 
            420                 425                 430         


Leu Ser Lys Arg Lys Leu Thr Trp Phe Val Asn Glu Gly Leu Val Asp 
        435                 440                 445             


Gly Trp Asp Asp Pro Arg Phe Pro Thr Val Arg Gly Val Leu Arg Arg 
    450                 455                 460                 


Gly Met Thr Val Glu Gly Leu Lys Gln Phe Ile Ala Ala Gln Gly Ser 
465                 470                 475                 480 


Ser Arg Ser Val Val Asn Met Glu Trp Asp Lys Ile Trp Ala Phe Asn 
                485                 490                 495     


Lys Lys Val Ile Asp Pro Val Ala Pro Arg Tyr Val Ala Leu Leu Lys 
            500                 505                 510         


Lys Glu Val Ile Pro Val Asn Val Pro Glu Ala Gln Glu Glu Met Lys 
        515                 520                 525             


Glu Val Ala Lys His Pro Lys Asn Pro Glu Val Gly Leu Lys Pro Val 
    530                 535                 540                 


Trp Tyr Ser Pro Lys Val Phe Ile Glu Gly Ala Asp Ala Glu Thr Phe 
545                 550                 555                 560 


Ser Glu Gly Glu Met Val Thr Phe Ile Asn Trp Gly Asn Leu Asn Ile 
                565                 570                 575     


Thr Lys Ile His Lys Asn Ala Asp Gly Lys Ile Ile Ser Leu Asp Ala 
            580                 585                 590         


Lys Leu Asn Leu Glu Asn Lys Asp Tyr Lys Lys Thr Thr Lys Val Thr 
        595                 600                 605             


Trp Leu Ala Glu Thr Thr His Ala Leu Pro Ile Pro Val Ile Cys Val 
    610                 615                 620                 


Thr Tyr Glu His Leu Ile Thr Lys Pro Val Leu Gly Lys Asp Glu Asp 
625                 630                 635                 640 


Phe Lys Gln Tyr Val Asn Lys Asn Ser Lys His Glu Glu Leu Met Leu 
                645                 650                 655     


Gly Asp Pro Cys Leu Lys Asp Leu Lys Lys Gly Asp Ile Ile Gln Leu 
            660                 665                 670         


Gln Arg Arg Gly Phe Phe Ile Cys Asp Gln Pro Tyr Glu Pro Val Ser 
        675                 680                 685             


Pro Tyr Ser Cys Lys Glu Ala Pro Cys Val Leu Ile Tyr Ile Pro Asp 
    690                 695                 700                 


Gly His Thr Lys Glu Met Pro Thr Ser Gly Ser Lys Glu Lys Thr Lys 
705                 710                 715                 720 


Val Glu Ala Thr Lys Asn Glu Thr Ser Ala Pro Phe Lys Glu Arg Pro 
                725                 730                 735     


Thr Pro Ser Leu Asn Asn Asn Cys Thr Thr Ser Glu Asp Ser Leu Val 
            740                 745                 750         


Leu Tyr Asn Arg Val Ala Val Gln Gly Asp Val Val Arg Glu Leu Lys 
        755                 760                 765             


Ala Lys Lys Ala Pro Lys Glu Asp Val Asp Ala Ala Val Lys Gln Leu 
    770                 775                 780                 


Leu Ser Leu Lys Ala Glu Tyr Lys Glu Lys Thr Gly Gln Glu Tyr Lys 
785                 790                 795                 800 


Pro Gly Asn Pro Pro Ala Glu Ile Gly Gln Asn Ile Ser Ser Asn Ser 
                805                 810                 815     


Ser Ala Ser Ile Leu Glu Ser Lys Ser Leu Tyr Asp Glu Val Ala Ala 
            820                 825                 830         


Gln Gly Glu Val Val Arg Lys Leu Lys Ala Glu Lys Ser Pro Lys Ala 
        835                 840                 845             


Lys Ile Asn Glu Ala Val Glu Cys Leu Leu Ser Leu Lys Ala Gln Tyr 
    850                 855                 860                 


Lys Glu Lys Thr Gly Lys Glu Tyr Ile Pro Gly Gln Pro Pro Leu Ser 
865                 870                 875                 880 


Gln Ser Ser Asp Ser Ser Pro Thr Arg Asn Ser Glu Pro Ala Gly Leu 
                885                 890                 895     


Glu Thr Pro Glu Ala Lys Val Leu Phe Asp Lys Val Ala Ser Gln Gly 
            900                 905                 910         


Glu Val Val Arg Lys Leu Lys Thr Glu Lys Ala Pro Lys Asp Gln Val 
        915                 920                 925             


Asp Ile Ala Val Gln Glu Leu Leu Gln Leu Lys Ala Gln Tyr Lys Ser 
    930                 935                 940                 


Leu Ile Gly Val Glu Tyr Lys Pro Val Ser Ala Thr Gly Ala Glu Asp 
945                 950                 955                 960 


Lys Asp Lys Lys Lys Lys Glu Lys Glu Asn Lys Ser Glu Lys Gln Asn 
                965                 970                 975     


Lys Pro Gln Lys Gln Asn Asp Gly Gln Arg Lys Asp Pro Ser Lys Asn 
            980                 985                 990         


Gln Gly Gly Gly Leu Ser Ser Ser  Gly Ala Gly Glu Gly  Gln Gly Pro 
        995                 1000                 1005             


Lys Lys  Gln Thr Arg Leu Gly  Leu Glu Ala Lys Lys  Glu Glu Asn 
    1010                 1015                 1020             


Leu Ala  Asp Trp Tyr Ser Gln  Val Ile Thr Lys Ser  Glu Met Ile 
    1025                 1030                 1035             


Glu Tyr  His Asp Ile Ser Gly  Cys Tyr Ile Leu Arg  Pro Trp Ala 
    1040                 1045                 1050             


Tyr Ala  Ile Trp Glu Ala Ile  Lys Asp Phe Phe Asp  Ala Glu Ile 
    1055                 1060                 1065             


Lys Lys  Leu Gly Val Glu Asn  Cys Tyr Phe Pro Met  Phe Val Ser 
    1070                 1075                 1080             


Gln Ser  Ala Leu Glu Lys Glu  Lys Thr His Val Ala  Asp Phe Ala 
    1085                 1090                 1095             


Pro Glu  Val Ala Trp Val Thr  Arg Ser Gly Lys Thr  Glu Leu Ala 
    1100                 1105                 1110             


Glu Pro  Ile Ala Ile Arg Pro  Thr Ser Glu Thr Val  Met Tyr Pro 
    1115                 1120                 1125             


Ala Tyr  Ala Lys Trp Val Gln  Ser His Arg Asp Leu  Pro Ile Lys 
    1130                 1135                 1140             


Leu Asn  Gln Trp Cys Asn Val  Val Arg Trp Glu Phe  Lys His Pro 
    1145                 1150                 1155             


Gln Pro  Phe Leu Arg Thr Arg  Glu Phe Leu Trp Gln  Glu Gly His 
    1160                 1165                 1170             


Ser Ala  Phe Ala Thr Met Glu  Glu Ala Ala Glu Glu  Val Leu Gln 
    1175                 1180                 1185             


Ile Leu  Asp Leu Tyr Ala Gln  Val Tyr Glu Glu Leu  Leu Ala Ile 
    1190                 1195                 1200             


Pro Val  Val Lys Gly Arg Lys  Thr Glu Lys Glu Lys  Phe Ala Gly 
    1205                 1210                 1215             


Gly Asp  Tyr Thr Thr Thr Ile  Glu Ala Phe Ile Ser  Ala Ser Gly 
    1220                 1225                 1230             


Arg Ala  Ile Gln Gly Gly Thr  Ser His His Leu Gly  Gln Asn Phe 
    1235                 1240                 1245             


Ser Lys  Met Phe Glu Ile Val  Phe Glu Asp Pro Lys  Ile Pro Gly 
    1250                 1255                 1260             


Glu Lys  Gln Phe Ala Tyr Gln  Asn Ser Trp Gly Leu  Thr Thr Arg 
    1265                 1270                 1275             


Thr Ile  Gly Val Met Thr Met  Val His Gly Asp Asn  Met Gly Leu 
    1280                 1285                 1290             


Val Leu  Pro Pro Arg Val Ala  Cys Val Gln Val Val  Ile Ile Pro 
    1295                 1300                 1305             


Cys Gly  Ile Thr Asn Ala Leu  Ser Glu Glu Asp Lys  Glu Ala Leu 
    1310                 1315                 1320             


Ile Ala  Lys Cys Asn Asp Tyr  Arg Arg Arg Leu Leu  Ser Val Asn 
    1325                 1330                 1335             


Ile Arg  Val Arg Ala Asp Leu  Arg Asp Asn Tyr Ser  Pro Gly Trp 
    1340                 1345                 1350             


Lys Phe  Asn His Trp Glu Leu  Lys Gly Val Pro Ile  Arg Leu Glu 
    1355                 1360                 1365             


Val Gly  Pro Arg Asp Met Lys  Ser Cys Gln Phe Val  Ala Val Arg 
    1370                 1375                 1380             


Arg Asp  Thr Gly Glu Lys Leu  Thr Val Ala Glu Asn  Glu Ala Glu 
    1385                 1390                 1395             


Thr Lys  Leu Gln Ala Ile Leu  Glu Asp Ile Gln Val  Thr Leu Phe 
    1400                 1405                 1410             


Thr Arg  Ala Ser Glu Asp Leu  Lys Thr His Met Val  Val Ala Asn 
    1415                 1420                 1425             


Thr Met  Glu Asp Phe Gln Lys  Ile Leu Asp Ser Gly  Lys Ile Val 
    1430                 1435                 1440             


Gln Ile  Pro Phe Cys Gly Glu  Ile Asp Cys Glu Asp  Trp Ile Lys 
    1445                 1450                 1455             


Lys Thr  Thr Ala Arg Asp Gln  Asp Leu Glu Pro Gly  Ala Pro Ser 
    1460                 1465                 1470             


Met Gly  Ala Lys Ser Leu Cys  Ile Pro Phe Lys Pro  Leu Cys Glu 
    1475                 1480                 1485             


Leu Gln  Pro Gly Ala Lys Cys  Val Cys Gly Lys Asn  Pro Ala Lys 
    1490                 1495                 1500             


Tyr Tyr  Thr Leu Phe Gly Arg  Ser Tyr 
    1505                 1510         


<210>  3617
<211>  910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPS15L1__Homo_sapiens__NP_001245303

<400>  3617

Met Ala Ala Pro Leu Ile Pro Leu Ser Gln Gln Ile Pro Thr Gly Asn 
1               5                   10                  15      


Ser Leu Tyr Glu Ser Tyr Tyr Lys Gln Val Asp Pro Ala Tyr Thr Gly 
            20                  25                  30          


Arg Val Gly Ala Ser Glu Ala Ala Leu Phe Leu Lys Lys Ser Gly Leu 
        35                  40                  45              


Ser Asp Ile Ile Leu Gly Lys Ile Trp Asp Leu Ala Asp Pro Glu Gly 
    50                  55                  60                  


Lys Gly Phe Leu Asp Lys Gln Gly Phe Tyr Val Ala Leu Arg Leu Val 
65                  70                  75                  80  


Ala Cys Ala Gln Ser Gly His Glu Val Thr Leu Ser Asn Leu Asn Leu 
                85                  90                  95      


Ser Met Pro Pro Pro Lys Phe His Asp Thr Ser Ser Pro Leu Met Val 
            100                 105                 110         


Thr Pro Pro Ser Ala Glu Ala His Trp Ala Val Arg Val Glu Glu Lys 
        115                 120                 125             


Ala Lys Phe Asp Gly Ile Phe Glu Ser Leu Leu Pro Ile Asn Gly Leu 
    130                 135                 140                 


Leu Ser Gly Asp Lys Val Lys Pro Val Leu Met Asn Ser Lys Leu Pro 
145                 150                 155                 160 


Leu Asp Val Leu Gly Arg Val Trp Asp Leu Ser Asp Ile Asp Lys Asp 
                165                 170                 175     


Gly His Leu Asp Arg Asp Glu Phe Ala Val Ala Met His Leu Val Tyr 
            180                 185                 190         


Arg Ala Leu Glu Lys Glu Pro Val Pro Ser Ala Leu Pro Pro Ser Leu 
        195                 200                 205             


Ile Pro Pro Ser Lys Arg Lys Lys Thr Val Phe Pro Gly Ala Val Pro 
    210                 215                 220                 


Val Leu Pro Ala Ser Pro Pro Pro Lys Asp Ser Leu Arg Ser Thr Pro 
225                 230                 235                 240 


Ser His Gly Ser Val Ser Ser Leu Asn Ser Thr Gly Ser Leu Ser Pro 
                245                 250                 255     


Lys His Ser Leu Lys Gln Thr Gln Pro Thr Val Asn Trp Val Val Pro 
            260                 265                 270         


Val Ala Asp Lys Met Arg Phe Asp Glu Ile Phe Leu Lys Thr Asp Leu 
        275                 280                 285             


Asp Leu Asp Gly Tyr Val Ser Gly Gln Glu Val Lys Glu Ile Phe Met 
    290                 295                 300                 


His Ser Gly Leu Thr Gln Asn Leu Leu Ala His Ile Trp Ala Leu Ala 
305                 310                 315                 320 


Asp Thr Arg Gln Thr Gly Lys Leu Ser Lys Asp Gln Phe Ala Leu Ala 
                325                 330                 335     


Met Tyr Phe Ile Gln Gln Lys Val Ser Lys Gly Ile Asp Pro Pro Gln 
            340                 345                 350         


Val Leu Ser Pro Asp Met Val Pro Pro Ser Glu Arg Gly Thr Pro Gly 
        355                 360                 365             


Pro Asp Ser Ser Gly Ser Leu Gly Ser Gly Glu Phe Thr Gly Val Lys 
    370                 375                 380                 


Glu Leu Asp Asp Ile Ser Gln Glu Ile Ala Gln Leu Gln Arg Glu Lys 
385                 390                 395                 400 


Tyr Ser Leu Glu Gln Asp Ile Arg Glu Lys Glu Glu Ala Ile Arg Gln 
                405                 410                 415     


Lys Thr Ser Glu Val Gln Glu Leu Gln Asn Asp Leu Asp Arg Glu Thr 
            420                 425                 430         


Ser Ser Leu Gln Glu Leu Glu Ala Gln Lys Gln Asp Ala Gln Asp Arg 
        435                 440                 445             


Leu Asp Glu Met Asp Gln Gln Lys Ala Lys Leu Arg Asp Met Leu Ser 
    450                 455                 460                 


Asp Val Arg Gln Lys Cys Gln Asp Glu Thr Gln Met Ile Ser Ser Leu 
465                 470                 475                 480 


Lys Thr Gln Ile Gln Ser Gln Glu Ser Asp Leu Lys Ser Gln Glu Asp 
                485                 490                 495     


Asp Leu Asn Arg Ala Lys Ser Glu Leu Asn Arg Leu Gln Gln Glu Glu 
            500                 505                 510         


Thr Gln Leu Glu Gln Ser Ile Gln Ala Gly Arg Val Gln Leu Glu Thr 
        515                 520                 525             


Ile Ile Lys Ser Leu Lys Ser Thr Gln Asp Glu Ile Asn Gln Ala Arg 
    530                 535                 540                 


Ser Lys Leu Ser Gln Leu His Glu Ser Arg Gln Glu Ala His Arg Ser 
545                 550                 555                 560 


Leu Glu Gln Tyr Asp Gln Val Leu Asp Gly Ala His Gly Ala Ser Leu 
                565                 570                 575     


Thr Asp Leu Ala Asn Leu Ser Glu Gly Val Ser Leu Ala Glu Arg Gly 
            580                 585                 590         


Ser Phe Gly Ala Met Asp Asp Pro Phe Lys Asn Lys Ala Leu Leu Phe 
        595                 600                 605             


Ser Asn Asn Thr Gln Glu Leu His Pro Asp Pro Phe Gln Thr Glu Asp 
    610                 615                 620                 


Pro Phe Lys Ser Asp Pro Phe Lys Gly Ala Asp Pro Phe Lys Gly Asp 
625                 630                 635                 640 


Pro Phe Gln Asn Asp Pro Phe Ala Glu Gln Gln Thr Thr Ser Thr Asp 
                645                 650                 655     


Pro Phe Gly Gly Asp Pro Phe Lys Glu Ser Asp Pro Phe Arg Gly Ser 
            660                 665                 670         


Ala Thr Asp Asp Phe Phe Lys Lys Gln Thr Lys Asn Asp Pro Phe Thr 
        675                 680                 685             


Ser Asp Pro Phe Thr Lys Asn Pro Ser Leu Pro Ser Lys Leu Asp Pro 
    690                 695                 700                 


Phe Glu Ser Ser Asp Pro Phe Ser Ser Ser Ser Val Ser Ser Lys Gly 
705                 710                 715                 720 


Ser Asp Pro Phe Gly Thr Leu Asp Pro Phe Gly Ser Gly Ser Phe Asn 
                725                 730                 735     


Ser Ala Glu Gly Phe Ala Asp Phe Ser Gln Met Ser Lys Pro Pro Pro 
            740                 745                 750         


Ser Gly Pro Phe Thr Ser Ser Leu Gly Gly Ala Gly Phe Ser Asp Asp 
        755                 760                 765             


Pro Phe Lys Ser Lys Gln Asp Thr Pro Ala Leu Pro Pro Lys Lys Pro 
    770                 775                 780                 


Ala Pro Pro Arg Pro Lys Pro Pro Ser Gly Lys Ser Thr Pro Val Ser 
785                 790                 795                 800 


Gln Leu Gly Ser Ala Asp Phe Pro Glu Ala Pro Asp Pro Phe Gln Pro 
                805                 810                 815     


Leu Gly Ala Asp Ser Gly Asp Pro Phe Gln Ser Lys Lys Gly Phe Gly 
            820                 825                 830         


Asp Pro Phe Ser Gly Lys Asp Pro Phe Val Pro Ser Ser Ala Ala Lys 
        835                 840                 845             


Pro Ser Lys Ala Ser Ala Ser Gly Phe Ala Asp Phe Thr Ser Phe Gly 
    850                 855                 860                 


Asn Glu Glu Gln Gln Leu Ala Trp Ala Lys Arg Glu Ser Glu Lys Ala 
865                 870                 875                 880 


Glu Gln Glu Arg Leu Ala Arg Leu Arg Arg Gln Glu Gln Glu Asp Leu 
                885                 890                 895     


Glu Leu Ala Ile Ala Leu Ser Lys Ala Asp Met Pro Ala Ala 
            900                 905                 910 


<210>  3618
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPS8__Homo_sapiens__XP_005253396

<400>  3618

Met Ser Asn Leu Asn Thr Gln Val Lys Asp Thr Met Asn Gly His Ile 
1               5                   10                  15      


Ser Asn His Pro Ser Ser Phe Gly Met Tyr Pro Ser Gln Met Asn Gly 
            20                  25                  30          


Tyr Gly Ser Ser Pro Thr Phe Ser Gln Thr Asp Arg Glu His Gly Ser 
        35                  40                  45              


Lys Thr Ser Ala Lys Ala Leu Tyr Glu Gln Arg Lys Asn Tyr Ala Arg 
    50                  55                  60                  


Asp Ser Val Ser Ser Val Ser Asp Ile Ser Gln Tyr Arg Val Glu His 
65                  70                  75                  80  


Leu Thr Thr Phe Val Leu Asp Arg Lys Asp Ala Met Ile Thr Val Asp 
                85                  90                  95      


Asp Gly Ile Arg Lys Leu Lys Leu Leu Asp Ala Lys Gly Lys Val Trp 
            100                 105                 110         


Thr Gln Asp Met Ile Leu Gln Val Asp Asp Arg Ala Val Ser Leu Ile 
        115                 120                 125             


Asp Leu Glu Ser Lys Asn Glu Leu Glu Asn Phe Pro Leu Asn Thr Ile 
    130                 135                 140                 


Gln His Cys Gln Ala Val Met His Ser Cys Ser Tyr Asp Ser Val Leu 
145                 150                 155                 160 


Ala Leu Val Cys Lys Glu Pro Thr Gln Asn Lys Pro Asp Leu His Leu 
                165                 170                 175     


Phe Gln Cys Asp Glu Val Lys Ala Asn Leu Ile Ser Glu Asp Ile Glu 
            180                 185                 190         


Ser Ala Ile Ser Asp Ser Lys Gly Gly Lys Gln Lys Arg Arg Pro Asp 
        195                 200                 205             


Ala Leu Arg Met Ile Ser Asn Ala Asp Pro Ser Ile Pro Pro Pro Pro 
    210                 215                 220                 


Arg Ala Pro Ala Pro Ala Pro Pro Gly Thr Val Thr Gln Val Asp Val 
225                 230                 235                 240 


Arg Ser Arg Val Ala Ala Trp Ser Ala Trp Ala Ala Asp Gln Gly Asp 
                245                 250                 255     


Phe Glu Lys Pro Arg Gln Tyr His Glu Gln Glu Glu Thr Pro Glu Met 
            260                 265                 270         


Met Ala Ala Arg Ile Asp Arg Asp Val Gln Ile Leu Asn His Ile Leu 
        275                 280                 285             


Asp Asp Ile Glu Phe Phe Ile Thr Lys Leu Gln Lys Ala Ala Glu Ala 
    290                 295                 300                 


Phe Ser Glu Leu Ser Lys Arg Lys Lys Asn Lys Lys Gly Lys Arg Lys 
305                 310                 315                 320 


Gly Pro Gly Glu Gly Val Leu Thr Leu Arg Ala Lys Pro Pro Pro Pro 
                325                 330                 335     


Asp Glu Phe Leu Asp Cys Phe Gln Lys Phe Lys His Gly Phe Asn Leu 
            340                 345                 350         


Leu Ala Lys Leu Lys Ser His Ile Gln Asn Pro Ser Ala Ala Asp Leu 
        355                 360                 365             


Val His Phe Leu Phe Thr Pro Leu Asn Met Val Val Gln Ala Thr Gly 
    370                 375                 380                 


Gly Pro Glu Leu Ala Ser Ser Val Leu Ser Pro Leu Leu Asn Lys Asp 
385                 390                 395                 400 


Thr Ile Asp Phe Leu Asn Tyr Thr Val Asn Gly Asp Glu Arg Gln Leu 
                405                 410                 415     


Trp Met Ser Leu Gly Gly Thr Trp Met Lys Ala Arg Ala Glu Trp Pro 
            420                 425                 430         


Lys Glu Gln Phe Ile Pro Pro Tyr Val Pro Arg Phe Arg Asn Gly Trp 
        435                 440                 445             


Glu Pro Pro Met Leu Asn Phe Met Gly Ala Thr Met Glu Gln Asp Leu 
    450                 455                 460                 


Tyr Gln Leu Ala Glu Ser Val Ala Asn Val Ala Glu His Gln Arg Lys 
465                 470                 475                 480 


Gln Glu Ile Lys Arg Leu Ser Thr Glu His Ser Ser Val Ser Glu Tyr 
                485                 490                 495     


His Pro Ala Asp Gly Tyr Ala Phe Ser Ser Asn Ile Tyr Thr Arg Gly 
            500                 505                 510         


Ser His Leu Asp Gln Gly Glu Ala Ala Val Ala Phe Lys Pro Thr Ser 
        515                 520                 525             


Asn Arg His Ile Asp Arg Asn Tyr Glu Pro Leu Lys Thr Gln Pro Lys 
    530                 535                 540                 


Lys Tyr Ala Lys Ser Lys Tyr Asp Phe Val Ala Arg Asn Asn Ser Glu 
545                 550                 555                 560 


Leu Ser Val Leu Lys Asp Asp Ile Leu Glu Ile Leu Asp Asp Arg Lys 
                565                 570                 575     


Gln Trp Trp Lys Val Arg Asn Ala Ser Gly Asp Ser Gly Phe Val Pro 
            580                 585                 590         


Asn Asn Ile Leu Asp Ile Val Arg Pro Pro Glu Ser Gly Leu Gly Arg 
        595                 600                 605             


Ala Asp Pro Pro Tyr Thr His Thr Ile Gln Lys Gln Arg Met Glu Tyr 
    610                 615                 620                 


Gly Pro Arg Pro Ala Asp Thr Pro Pro Ala Pro Ser Pro Pro Pro Thr 
625                 630                 635                 640 


Pro Ala Pro Val Pro Val Pro Leu Pro Pro Ser Thr Pro Ala Pro Val 
                645                 650                 655     


Pro Val Ser Lys Val Pro Ala Asn Ile Thr Arg Gln Asn Ser Ser Ser 
            660                 665                 670         


Ser Asp Ser Gly Gly Ser Ile Val Arg Asp Ser Gln Arg His Lys Gln 
        675                 680                 685             


Leu Pro Val Asp Arg Arg Lys Ser Gln Met Glu Glu Val Gln Asp Glu 
    690                 695                 700                 


Leu Ile His Arg Leu Thr Ile Gly Arg Ser Ala Ala Gln Lys Lys Phe 
705                 710                 715                 720 


His Val Pro Arg Gln Asn Val Pro Val Ile Asn Ile Thr Tyr Asp Ser 
                725                 730                 735     


Thr Pro Glu Asp Val Lys Thr Trp Leu Gln Ser Lys Gly Phe Asn Pro 
            740                 745                 750         


Val Thr Val Asn Ser Leu Gly Val Leu Asn Gly Ala Gln Leu Phe Ser 
        755                 760                 765             


Leu Asn Lys Asp Glu Leu Arg Thr Val Cys Pro Glu Gly Ala Arg Val 
    770                 775                 780                 


Tyr Ser Gln Ile Thr Val Gln Lys Ala Ala Leu Glu Asp Ser Ser Gly 
785                 790                 795                 800 


Ser Ser Glu Leu Gln Glu Ile Met Arg Arg Arg Gln Glu Lys Ile Ser 
                805                 810                 815     


Ala Ala Ala Ser Asp Ser Gly Val Glu Ser Phe Asp Glu Gly Ser Ser 
            820                 825                 830         


His 
    


<210>  3619
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPS8L2__Homo_sapiens__NP_073609

<400>  3619

Met Ser Gln Ser Gly Ala Val Ser Cys Cys Pro Gly Ala Thr Asn Gly 
1               5                   10                  15      


Ser Leu Gly Arg Ser Asp Gly Val Ala Lys Met Ser Pro Lys Asp Leu 
            20                  25                  30          


Phe Glu Gln Arg Lys Lys Tyr Ser Asn Ser Asn Val Ile Met His Glu 
        35                  40                  45              


Thr Ser Gln Tyr His Val Gln His Leu Ala Thr Phe Ile Met Asp Lys 
    50                  55                  60                  


Ser Glu Ala Ile Thr Ser Val Asp Asp Ala Ile Arg Lys Leu Val Gln 
65                  70                  75                  80  


Leu Ser Ser Lys Glu Lys Ile Trp Thr Gln Glu Met Leu Leu Gln Val 
                85                  90                  95      


Asn Asp Gln Ser Leu Arg Leu Leu Asp Ile Glu Ser Gln Glu Glu Leu 
            100                 105                 110         


Glu Asp Phe Pro Leu Pro Thr Val Gln Arg Ser Gln Thr Val Leu Asn 
        115                 120                 125             


Gln Leu Arg Tyr Pro Ser Val Leu Leu Leu Val Cys Gln Asp Ser Glu 
    130                 135                 140                 


Gln Ser Lys Pro Asp Val His Phe Phe His Cys Asp Glu Val Glu Ala 
145                 150                 155                 160 


Glu Leu Val His Glu Asp Ile Glu Ser Ala Leu Ala Asp Cys Arg Leu 
                165                 170                 175     


Gly Lys Lys Met Arg Pro Gln Thr Leu Lys Gly His Gln Glu Lys Ile 
            180                 185                 190         


Arg Gln Arg Gln Ser Ile Leu Pro Pro Pro Gln Gly Pro Ala Pro Ile 
        195                 200                 205             


Pro Phe Gln His Arg Gly Gly Asp Ser Pro Glu Ala Lys Asn Arg Val 
    210                 215                 220                 


Gly Pro Gln Val Pro Leu Ser Glu Pro Gly Phe Arg Arg Arg Glu Ser 
225                 230                 235                 240 


Gln Glu Glu Pro Arg Ala Val Leu Ala Gln Lys Ile Glu Lys Glu Thr 
                245                 250                 255     


Gln Ile Leu Asn Cys Ala Leu Asp Asp Ile Glu Trp Phe Val Ala Arg 
            260                 265                 270         


Leu Gln Lys Ala Ala Glu Ala Phe Lys Gln Leu Asn Gln Arg Lys Lys 
        275                 280                 285             


Gly Lys Lys Lys Gly Lys Lys Ala Pro Ala Glu Gly Val Leu Thr Leu 
    290                 295                 300                 


Arg Ala Arg Pro Pro Ser Glu Gly Glu Phe Ile Asp Cys Phe Gln Lys 
305                 310                 315                 320 


Ile Lys Leu Ala Ile Asn Leu Leu Ala Lys Leu Gln Lys His Ile Gln 
                325                 330                 335     


Asn Pro Ser Ala Ala Glu Leu Val His Phe Leu Phe Gly Pro Leu Asp 
            340                 345                 350         


Leu Ile Val Asn Thr Cys Ser Gly Pro Asp Ile Ala Arg Ser Val Ser 
        355                 360                 365             


Cys Pro Leu Leu Ser Arg Asp Ala Val Asp Phe Leu Arg Gly His Leu 
    370                 375                 380                 


Val Pro Lys Glu Met Ser Leu Trp Glu Ser Leu Gly Glu Ser Trp Met 
385                 390                 395                 400 


Arg Pro Arg Ser Glu Trp Pro Arg Glu Pro Gln Val Pro Leu Tyr Val 
                405                 410                 415     


Pro Lys Phe His Ser Gly Trp Glu Pro Pro Val Asp Val Leu Gln Glu 
            420                 425                 430         


Ala Pro Trp Glu Val Glu Gly Leu Ala Ser Ala Pro Ile Glu Glu Val 
        435                 440                 445             


Ser Pro Val Ser Arg Gln Ser Ile Arg Asn Ser Gln Lys His Ser Pro 
    450                 455                 460                 


Thr Ser Glu Pro Thr Pro Pro Gly Asp Ala Leu Pro Pro Val Ser Ser 
465                 470                 475                 480 


Pro His Thr His Arg Gly Tyr Gln Pro Thr Pro Ala Met Ala Lys Tyr 
                485                 490                 495     


Val Lys Ile Leu Tyr Asp Phe Thr Ala Arg Asn Ala Asn Glu Leu Ser 
            500                 505                 510         


Val Leu Lys Asp Glu Val Leu Glu Val Leu Glu Asp Gly Arg Gln Trp 
        515                 520                 525             


Trp Lys Leu Arg Ser Arg Ser Gly Gln Ala Gly Tyr Val Pro Cys Asn 
    530                 535                 540                 


Ile Leu Gly Glu Ala Arg Pro Glu Asp Ala Gly Ala Pro Phe Glu Gln 
545                 550                 555                 560 


Ala Gly Gln Lys Tyr Trp Gly Pro Ala Ser Pro Thr His Lys Leu Pro 
                565                 570                 575     


Pro Ser Phe Pro Gly Asn Lys Asp Glu Leu Met Gln His Met Asp Glu 
            580                 585                 590         


Val Asn Asp Glu Leu Ile Arg Lys Ile Ser Asn Ile Arg Ala Gln Pro 
        595                 600                 605             


Gln Arg His Phe Arg Val Glu Arg Ser Gln Pro Val Ser Gln Pro Leu 
    610                 615                 620                 


Thr Tyr Glu Ser Gly Pro Asp Glu Val Arg Ala Trp Leu Glu Ala Lys 
625                 630                 635                 640 


Ala Phe Ser Pro Arg Ile Val Glu Asn Leu Gly Ile Leu Thr Gly Pro 
                645                 650                 655     


Gln Leu Phe Ser Leu Asn Lys Glu Glu Leu Lys Lys Val Cys Gly Glu 
            660                 665                 670         


Glu Gly Val Arg Val Tyr Ser Gln Leu Thr Met Gln Lys Ala Phe Leu 
        675                 680                 685             


Glu Lys Gln Gln Ser Gly Ser Glu Leu Glu Glu Leu Met Asn Lys Phe 
    690                 695                 700                 


His Ser Met Asn Gln Arg Arg Gly Glu Asp Ser 
705                 710                 715 


<210>  3620
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPSTI1__Homo_sapiens__NP_001002264

<400>  3620

Met Asn Thr Arg Asn Arg Val Val Asn Ser Gly Leu Gly Ala Ser Pro 
1               5                   10                  15      


Ala Ser Arg Pro Thr Arg Asp Pro Gln Asp Pro Ser Gly Arg Gln Gly 
            20                  25                  30          


Glu Leu Ser Pro Val Glu Asp Gln Arg Glu Gly Leu Glu Ala Ala Pro 
        35                  40                  45              


Lys Gly Pro Ser Arg Glu Ser Val Val His Ala Gly Gln Arg Arg Thr 
    50                  55                  60                  


Ser Ala Tyr Thr Leu Ile Ala Pro Asn Ile Asn Arg Arg Asn Glu Ile 
65                  70                  75                  80  


Gln Arg Ile Ala Glu Gln Glu Leu Ala Asn Leu Glu Lys Trp Lys Glu 
                85                  90                  95      


Gln Asn Arg Ala Lys Pro Val His Leu Val Pro Arg Arg Leu Gly Gly 
            100                 105                 110         


Ser Gln Ser Glu Thr Glu Val Arg Gln Lys Gln Gln Leu Gln Leu Met 
        115                 120                 125             


Gln Ser Lys Tyr Lys Gln Lys Leu Lys Arg Glu Glu Ser Val Arg Ile 
    130                 135                 140                 


Lys Lys Glu Ala Glu Glu Ala Glu Leu Gln Lys Met Lys Ala Ile Gln 
145                 150                 155                 160 


Arg Glu Lys Ser Asn Lys Leu Glu Glu Lys Lys Arg Leu Gln Glu Asn 
                165                 170                 175     


Leu Arg Arg Glu Ala Phe Arg Glu His Gln Gln Tyr Lys Thr Ala Glu 
            180                 185                 190         


Phe Leu Ser Lys Leu Asn Thr Glu Ser Pro Asp Arg Ser Ala Cys Gln 
        195                 200                 205             


Ser Ala Val Cys Gly Pro Gln Ser Ser Thr Trp Lys Leu Pro Ile Leu 
    210                 215                 220                 


Pro Arg Asp His Ser Trp Ala Arg Ser Trp Ala Tyr Arg Asp Ser Leu 
225                 230                 235                 240 


Lys Ala Glu Glu Asn Arg Lys Leu Gln Lys Met Lys Asp Glu Gln His 
                245                 250                 255     


Gln Lys Ser Glu Leu Leu Glu Leu Lys Arg Gln Gln Gln Glu Gln Glu 
            260                 265                 270         


Arg Ala Lys Ile His Gln Thr Glu His Arg Arg Val Asn Asn Ala Phe 
        275                 280                 285             


Leu Asp Arg Leu Gln Gly Lys Ser Gln Pro Gly Gly Leu Glu Gln Ser 
    290                 295                 300                 


Gly Gly Cys Trp Asn Met Asn Ser Gly Asn Ser Trp Gly Ser Leu Leu 
305                 310                 315                 320 


Val Phe Ser Arg His Leu Arg Val Tyr Glu Lys Ile Leu Thr Pro Ile 
                325                 330                 335     


Trp Pro Ser Ser Thr Asp Leu Glu Lys Pro His Glu Met Leu Phe Leu 
            340                 345                 350         


Asn Val Ile Leu Phe Ser Leu Thr Val Phe Thr Leu Ile Ser Thr Ala 
        355                 360                 365             


His Thr Leu Asp Arg Ala Val Arg Ser Asp Trp Leu Leu Leu Val Leu 
    370                 375                 380                 


Ile Tyr Ala Cys Leu Glu Glu Leu Ile Pro Glu Leu Ile Phe Asn Leu 
385                 390                 395                 400 


Tyr Cys Gln Gly Asn Ala Thr Leu Phe Phe 
                405                 410 


<210>  3621
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPX__Homo_sapiens__NP_000493

<400>  3621

Met His Leu Leu Pro Ala Leu Ala Gly Val Leu Ala Thr Leu Val Leu 
1               5                   10                  15      


Ala Gln Pro Cys Glu Gly Thr Asp Pro Ala Ser Pro Gly Ala Val Glu 
            20                  25                  30          


Thr Ser Val Leu Arg Asp Cys Ile Ala Glu Ala Lys Leu Leu Val Asp 
        35                  40                  45              


Ala Ala Tyr Asn Trp Thr Gln Lys Ser Ile Lys Gln Arg Leu Arg Ser 
    50                  55                  60                  


Gly Ser Ala Ser Pro Met Asp Leu Leu Ser Tyr Phe Lys Gln Pro Val 
65                  70                  75                  80  


Ala Ala Thr Arg Thr Val Val Arg Ala Ala Asp Tyr Met His Val Ala 
                85                  90                  95      


Leu Gly Leu Leu Glu Glu Lys Leu Gln Pro Gln Arg Ser Gly Pro Phe 
            100                 105                 110         


Asn Val Thr Asp Val Leu Thr Glu Pro Gln Leu Arg Leu Leu Ser Gln 
        115                 120                 125             


Ala Ser Gly Cys Ala Leu Arg Asp Gln Ala Glu Arg Cys Ser Asp Lys 
    130                 135                 140                 


Tyr Arg Thr Ile Thr Gly Arg Cys Asn Asn Lys Arg Arg Pro Leu Leu 
145                 150                 155                 160 


Gly Ala Ser Asn Gln Ala Leu Ala Arg Trp Leu Pro Ala Glu Tyr Glu 
                165                 170                 175     


Asp Gly Leu Ser Leu Pro Phe Gly Trp Thr Pro Ser Arg Arg Arg Asn 
            180                 185                 190         


Gly Phe Leu Leu Pro Leu Val Arg Ala Val Ser Asn Gln Ile Val Arg 
        195                 200                 205             


Phe Pro Asn Glu Arg Leu Thr Ser Asp Arg Gly Arg Ala Leu Met Phe 
    210                 215                 220                 


Met Gln Trp Gly Gln Phe Ile Asp His Asp Leu Asp Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Pro Ala Arg Val Ala Phe Thr Ala Gly Val Asp Cys Glu Arg Thr 
                245                 250                 255     


Cys Ala Gln Leu Pro Pro Cys Phe Pro Ile Lys Ile Pro Pro Asn Asp 
            260                 265                 270         


Pro Arg Ile Lys Asn Gln Arg Asp Cys Ile Pro Phe Phe Arg Ser Ala 
        275                 280                 285             


Pro Ser Cys Pro Gln Asn Lys Asn Arg Val Arg Asn Gln Ile Asn Ala 
    290                 295                 300                 


Leu Thr Ser Phe Val Asp Ala Ser Met Val Tyr Gly Ser Glu Val Ser 
305                 310                 315                 320 


Leu Ser Leu Arg Leu Arg Asn Arg Thr Asn Tyr Leu Gly Leu Leu Ala 
                325                 330                 335     


Ile Asn Gln Arg Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp 
            340                 345                 350         


Asn Leu His Asp Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile 
        355                 360                 365             


Pro Cys Phe Leu Ala Gly Asp Thr Arg Ser Thr Glu Thr Pro Lys Leu 
    370                 375                 380                 


Ala Ala Met His Thr Leu Phe Met Arg Glu His Asn Arg Leu Ala Thr 
385                 390                 395                 400 


Glu Leu Arg Arg Leu Asn Pro Arg Trp Asn Gly Asp Lys Leu Tyr Asn 
                405                 410                 415     


Glu Ala Arg Lys Ile Met Gly Ala Met Val Gln Ile Ile Thr Tyr Arg 
            420                 425                 430         


Asp Phe Leu Pro Leu Val Leu Gly Lys Ala Arg Ala Arg Arg Thr Leu 
        435                 440                 445             


Gly His Tyr Arg Gly Tyr Cys Ser Asn Val Asp Pro Arg Val Ala Asn 
    450                 455                 460                 


Val Phe Thr Leu Ala Phe Arg Phe Gly His Thr Met Leu Gln Pro Phe 
465                 470                 475                 480 


Met Phe Arg Leu Asp Ser Gln Tyr Arg Ala Ser Ala Pro Asn Ser His 
                485                 490                 495     


Val Pro Leu Ser Ser Ala Phe Phe Ala Ser Trp Arg Ile Val Tyr Glu 
            500                 505                 510         


Gly Gly Ile Asp Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys 
        515                 520                 525             


Leu Asn Arg Gln Asp Ala Met Leu Val Asp Glu Leu Arg Asp Arg Leu 
    530                 535                 540                 


Phe Arg Gln Val Arg Arg Ile Gly Leu Asp Leu Ala Ala Leu Asn Met 
545                 550                 555                 560 


Gln Arg Ser Arg Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg 
                565                 570                 575     


Phe Cys Gly Leu Ser Gln Pro Arg Asn Leu Ala Gln Leu Ser Arg Val 
            580                 585                 590         


Leu Lys Asn Gln Asp Leu Ala Arg Lys Phe Leu Asn Leu Tyr Gly Thr 
        595                 600                 605             


Pro Asp Asn Ile Asp Ile Trp Ile Gly Ala Ile Ala Glu Pro Leu Leu 
    610                 615                 620                 


Pro Gly Ala Arg Val Gly Pro Leu Leu Ala Cys Leu Phe Glu Asn Gln 
625                 630                 635                 640 


Phe Arg Arg Ala Arg Asp Gly Asp Arg Phe Trp Trp Gln Lys Arg Gly 
                645                 650                 655     


Val Phe Thr Lys Arg Gln Arg Lys Ala Leu Ser Arg Ile Ser Leu Ser 
            660                 665                 670         


Arg Ile Ile Cys Asp Asn Thr Gly Ile Thr Thr Val Ser Arg Asp Ile 
        675                 680                 685             


Phe Arg Ala Asn Ile Tyr Pro Arg Gly Phe Val Asn Cys Ser Arg Ile 
    690                 695                 700                 


Pro Arg Leu Asn Leu Ser Ala Trp Arg Gly Thr 
705                 710                 715 


<210>  3622
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPYC__Homo_sapiens__NP_004941

<400>  3622

Met Lys Thr Leu Ala Gly Leu Val Leu Gly Leu Val Ile Phe Asp Ala 
1               5                   10                  15      


Ala Val Thr Ala Pro Thr Leu Glu Ser Ile Asn Tyr Asp Ser Glu Thr 
            20                  25                  30          


Tyr Asp Ala Thr Leu Glu Asp Leu Asp Asn Leu Tyr Asn Tyr Glu Asn 
        35                  40                  45              


Ile Pro Val Asp Lys Val Glu Ile Glu Ile Ala Thr Val Met Pro Ser 
    50                  55                  60                  


Gly Asn Arg Glu Leu Leu Thr Pro Pro Pro Gln Pro Glu Lys Ala Gln 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Glu Glu Ser Thr Pro Arg Leu Ile Asp Gly Ser 
                85                  90                  95      


Ser Pro Gln Glu Pro Glu Phe Thr Gly Val Leu Gly Pro His Thr Asn 
            100                 105                 110         


Glu Asp Phe Pro Thr Cys Leu Leu Cys Thr Cys Ile Ser Thr Thr Val 
        115                 120                 125             


Tyr Cys Asp Asp His Glu Leu Asp Ala Ile Pro Pro Leu Pro Lys Asn 
    130                 135                 140                 


Thr Ala Tyr Phe Tyr Ser Arg Phe Asn Arg Ile Lys Lys Ile Asn Lys 
145                 150                 155                 160 


Asn Asp Phe Ala Ser Leu Ser Asp Leu Lys Arg Ile Asp Leu Thr Ser 
                165                 170                 175     


Asn Leu Ile Ser Glu Ile Asp Glu Asp Ala Phe Arg Lys Leu Pro Gln 
            180                 185                 190         


Leu Arg Glu Leu Val Leu Arg Asp Asn Lys Ile Arg Gln Leu Pro Glu 
        195                 200                 205             


Leu Pro Thr Thr Leu Thr Phe Ile Asp Ile Ser Asn Asn Arg Leu Gly 
    210                 215                 220                 


Arg Lys Gly Ile Lys Gln Glu Ala Phe Lys Asp Met Tyr Asp Leu His 
225                 230                 235                 240 


His Leu Tyr Leu Thr Asp Asn Asn Leu Asp His Ile Pro Leu Pro Leu 
                245                 250                 255     


Pro Glu Asn Leu Arg Ala Leu His Leu Gln Asn Asn Asn Ile Leu Glu 
            260                 265                 270         


Met His Glu Asp Thr Phe Cys Asn Val Lys Asn Leu Thr Tyr Ile Arg 
        275                 280                 285             


Lys Ala Leu Glu Asp Ile Arg Leu Asp Gly Asn Pro Ile Asn Leu Ser 
    290                 295                 300                 


Lys Thr Pro Gln Ala Tyr Met Cys Leu Pro Arg Leu Pro Val Gly Ser 
305                 310                 315                 320 


Leu Val 
        


<210>  3623
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERAL1__Homo_sapiens__NP_005693

<400>  3623

Met Ala Ala Pro Ser Trp Arg Gly Ala Arg Leu Val Gln Ser Val Leu 
1               5                   10                  15      


Arg Val Trp Gln Val Gly Pro His Val Ala Arg Glu Arg Val Ile Pro 
            20                  25                  30          


Phe Ser Ser Leu Leu Gly Phe Gln Arg Arg Cys Val Ser Cys Val Ala 
        35                  40                  45              


Gly Ser Ala Phe Ser Gly Pro Arg Leu Ala Ser Ala Ser Arg Ser Asn 
    50                  55                  60                  


Gly Gln Gly Ser Ala Leu Asp His Phe Leu Gly Phe Ser Gln Pro Asp 
65                  70                  75                  80  


Ser Ser Val Thr Pro Cys Val Pro Ala Val Ser Met Asn Arg Asp Glu 
                85                  90                  95      


Gln Asp Val Leu Leu Val His His Pro Asp Met Pro Glu Asn Ser Arg 
            100                 105                 110         


Val Leu Arg Val Val Leu Leu Gly Ala Pro Asn Ala Gly Lys Ser Thr 
        115                 120                 125             


Leu Ser Asn Gln Leu Leu Gly Arg Lys Val Phe Pro Val Ser Arg Lys 
    130                 135                 140                 


Val His Thr Thr Arg Cys Gln Ala Leu Gly Val Ile Thr Glu Lys Glu 
145                 150                 155                 160 


Thr Gln Val Ile Leu Leu Asp Thr Pro Gly Ile Ile Ser Pro Gly Lys 
                165                 170                 175     


Gln Lys Arg His His Leu Glu Leu Ser Leu Leu Glu Asp Pro Trp Lys 
            180                 185                 190         


Ser Met Glu Ser Ala Asp Leu Val Val Val Leu Val Asp Val Ser Asp 
        195                 200                 205             


Lys Trp Thr Arg Asn Gln Leu Ser Pro Gln Leu Leu Arg Cys Leu Thr 
    210                 215                 220                 


Lys Tyr Ser Gln Ile Pro Ser Val Leu Val Met Asn Lys Val Asp Cys 
225                 230                 235                 240 


Leu Lys Gln Lys Ser Val Leu Leu Glu Leu Thr Ala Ala Leu Thr Glu 
                245                 250                 255     


Gly Val Val Asn Gly Lys Lys Leu Lys Met Arg Gln Ala Phe His Ser 
            260                 265                 270         


His Pro Gly Thr His Cys Pro Ser Pro Ala Val Lys Asp Pro Asn Thr 
        275                 280                 285             


Gln Ser Val Gly Asn Pro Gln Arg Ile Gly Trp Pro His Phe Lys Glu 
    290                 295                 300                 


Ile Phe Met Leu Ser Ala Leu Ser Gln Glu Asp Val Lys Thr Leu Lys 
305                 310                 315                 320 


Gln Tyr Leu Leu Thr Gln Ala Gln Pro Gly Pro Trp Glu Tyr His Ser 
                325                 330                 335     


Ala Val Leu Thr Ser Gln Thr Pro Glu Glu Ile Cys Ala Asn Ile Ile 
            340                 345                 350         


Arg Glu Lys Leu Leu Glu His Leu Pro Gln Glu Val Pro Tyr Asn Val 
        355                 360                 365             


Gln Gln Lys Thr Ala Val Trp Glu Glu Gly Pro Gly Gly Glu Leu Val 
    370                 375                 380                 


Ile Gln Gln Lys Leu Leu Val Pro Lys Glu Ser Tyr Val Lys Leu Leu 
385                 390                 395                 400 


Ile Gly Pro Lys Gly His Val Ile Ser Gln Ile Ala Gln Glu Ala Gly 
                405                 410                 415     


His Asp Leu Met Asp Ile Phe Leu Cys Asp Val Asp Ile Arg Leu Ser 
            420                 425                 430         


Val Lys Leu Leu Lys 
        435         


<210>  3624
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERAP1__Homo_sapiens__NP_001185470

<400>  3624

Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met Ser Phe Leu 
1               5                   10                  15      


Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro Ser Trp Cys 
            20                  25                  30          


Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr Pro Phe Pro 
        35                  40                  45              


Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val His Tyr Asp 
    50                  55                  60                  


Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp Gly Thr Thr 
65                  70                  75                  80  


Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile Ile Leu His 
                85                  90                  95      


Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys Gly Ala Gly 
            100                 105                 110         


Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His Pro Arg Gln 
        115                 120                 125             


Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu Val Gly Leu Pro 
    130                 135                 140                 


Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser Glu Thr Phe His 
145                 150                 155                 160 


Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly Glu Leu Arg Ile 
                165                 170                 175     


Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg Met Ala Phe Pro 
            180                 185                 190         


Cys Phe Asp Glu Pro Ala Phe Lys Ala Ser Phe Ser Ile Lys Ile Arg 
        195                 200                 205             


Arg Glu Pro Arg His Leu Ala Ile Ser Asn Met Pro Leu Val Lys Ser 
    210                 215                 220                 


Val Thr Val Ala Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val 
225                 230                 235                 240 


Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser 
                245                 250                 255     


Val Ser Lys Ile Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val 
            260                 265                 270         


Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr 
        275                 280                 285             


Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro 
    290                 295                 300                 


Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu 
305                 310                 315                 320 


Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala 
                325                 330                 335     


Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile Thr Met Thr Val Ala 
            340                 345                 350         


His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp 
        355                 360                 365             


Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Lys Phe Met Glu Phe 
    370                 375                 380                 


Val Ser Val Ser Val Thr His Pro Glu Leu Lys Val Gly Asp Tyr Phe 
385                 390                 395                 400 


Phe Gly Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu Asn Ser Ser 
                405                 410                 415     


His Pro Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile Arg Glu Met 
            420                 425                 430         


Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala Cys Ile Leu Asn Met Leu 
        435                 440                 445             


Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys Ser Gly Ile Val Gln Tyr 
    450                 455                 460                 


Leu Gln Lys His Ser Tyr Lys Asn Thr Lys Asn Glu Asp Leu Trp Asp 
465                 470                 475                 480 


Ser Met Ala Ser Ile Cys Pro Thr Asp Gly Val Lys Gly Met Asp Gly 
                485                 490                 495     


Phe Cys Ser Arg Ser Gln His Ser Ser Ser Ser Ser His Trp His Gln 
            500                 505                 510         


Glu Gly Val Asp Val Lys Thr Met Met Asn Thr Trp Thr Leu Gln Lys 
        515                 520                 525             


Gly Phe Pro Leu Ile Thr Ile Thr Val Arg Gly Arg Asn Val His Met 
    530                 535                 540                 


Lys Gln Glu His Tyr Met Lys Gly Ser Asp Gly Ala Pro Asp Thr Gly 
545                 550                 555                 560 


Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp Met 
                565                 570                 575     


Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu Pro 
            580                 585                 590         


Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr Tyr 
        595                 600                 605             


Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu Leu 
    610                 615                 620                 


Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu Ile 
625                 630                 635                 640 


Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu Lys 
                645                 650                 655     


Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met Pro 
            660                 665                 670         


Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met Glu 
        675                 680                 685             


Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu Ile 
    690                 695                 700                 


Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu Gly 
705                 710                 715                 720 


Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala Cys 
                725                 730                 735     


Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe Arg 
            740                 745                 750         


Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val Thr 
        755                 760                 765             


Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp Phe 
    770                 775                 780                 


Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser Gln 
785                 790                 795                 800 


Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln Trp 
                805                 810                 815     


Leu Leu Asp Glu Ser Phe Lys Gly Asp Lys Ile Lys Thr Gln Glu Phe 
            820                 825                 830         


Pro Gln Ile Leu Thr Leu Ile Gly Arg Asn Pro Val Gly Tyr Pro Leu 
        835                 840                 845             


Ala Trp Gln Phe Leu Arg Lys Asn Trp Asn Lys Leu Val Gln Lys Phe 
    850                 855                 860                 


Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr Thr Asn 
865                 870                 875                 880 


Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Val Lys Gly Phe Phe Ser 
                885                 890                 895     


Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys Val Gln Gln Thr Ile 
            900                 905                 910         


Glu Thr Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys 
        915                 920                 925             


Ile Arg Val Trp Leu Gln Ser Glu Lys Leu Glu Arg Met 
    930                 935                 940     


<210>  3625
<211>  960
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERAP2__Homo_sapiens__NP_001123612

<400>  3625

Met Phe His Ser Ser Ala Met Val Asn Ser His Arg Lys Pro Met Phe 
1               5                   10                  15      


Asn Ile His Arg Gly Phe Tyr Cys Leu Thr Ala Ile Leu Pro Gln Ile 
            20                  25                  30          


Cys Ile Cys Ser Gln Phe Ser Val Pro Ser Ser Tyr His Phe Thr Glu 
        35                  40                  45              


Asp Pro Gly Ala Phe Pro Val Ala Thr Asn Gly Glu Arg Phe Pro Trp 
    50                  55                  60                  


Gln Glu Leu Arg Leu Pro Ser Val Val Ile Pro Leu His Tyr Asp Leu 
65                  70                  75                  80  


Phe Val His Pro Asn Leu Thr Ser Leu Asp Phe Val Ala Ser Glu Lys 
                85                  90                  95      


Ile Glu Val Leu Val Ser Asn Ala Thr Gln Phe Ile Ile Leu His Ser 
            100                 105                 110         


Lys Asp Leu Glu Ile Thr Asn Ala Thr Leu Gln Ser Glu Glu Asp Ser 
        115                 120                 125             


Arg Tyr Met Lys Pro Gly Lys Glu Leu Lys Val Leu Ser Tyr Pro Ala 
    130                 135                 140                 


His Glu Gln Ile Ala Leu Leu Val Pro Glu Lys Leu Thr Pro His Leu 
145                 150                 155                 160 


Lys Tyr Tyr Val Ala Met Asp Phe Gln Ala Lys Leu Gly Asp Gly Phe 
                165                 170                 175     


Glu Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Leu Gly Gly Glu Thr Arg 
            180                 185                 190         


Ile Leu Ala Val Thr Asp Phe Glu Pro Thr Gln Ala Arg Met Ala Phe 
        195                 200                 205             


Pro Cys Phe Asp Glu Pro Leu Phe Lys Ala Asn Phe Ser Ile Lys Ile 
    210                 215                 220                 


Arg Arg Glu Ser Arg His Ile Ala Leu Ser Asn Met Pro Lys Val Lys 
225                 230                 235                 240 


Thr Ile Glu Leu Glu Gly Gly Leu Leu Glu Asp His Phe Glu Thr Thr 
                245                 250                 255     


Val Lys Met Ser Thr Tyr Leu Val Ala Tyr Ile Val Cys Asp Phe His 
            260                 265                 270         


Ser Leu Ser Gly Phe Thr Ser Ser Gly Val Lys Val Ser Ile Tyr Ala 
        275                 280                 285             


Ser Pro Asp Lys Arg Asn Gln Thr His Tyr Ala Leu Gln Ala Ser Leu 
    290                 295                 300                 


Lys Leu Leu Asp Phe Tyr Glu Lys Tyr Phe Asp Ile Tyr Tyr Pro Leu 
305                 310                 315                 320 


Ser Lys Leu Asp Leu Ile Ala Ile Pro Asp Phe Ala Pro Gly Ala Met 
                325                 330                 335     


Glu Asn Trp Gly Leu Ile Thr Tyr Arg Glu Thr Ser Leu Leu Phe Asp 
            340                 345                 350         


Pro Lys Thr Ser Ser Ala Ser Asp Lys Leu Trp Val Thr Arg Val Ile 
        355                 360                 365             


Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu 
    370                 375                 380                 


Trp Trp Asn Asp Ile Trp Leu Lys Glu Gly Phe Ala Lys Tyr Met Glu 
385                 390                 395                 400 


Leu Ile Ala Val Asn Ala Thr Tyr Pro Glu Leu Gln Phe Asp Asp Tyr 
                405                 410                 415     


Phe Leu Asn Val Cys Phe Glu Val Ile Thr Lys Asp Ser Leu Asn Ser 
            420                 425                 430         


Ser Arg Pro Ile Ser Lys Pro Ala Glu Thr Pro Thr Gln Ile Gln Glu 
        435                 440                 445             


Met Phe Asp Glu Val Ser Tyr Asn Lys Gly Ala Cys Ile Leu Asn Met 
    450                 455                 460                 


Leu Lys Asp Phe Leu Gly Glu Glu Lys Phe Gln Lys Gly Ile Ile Gln 
465                 470                 475                 480 


Tyr Leu Lys Lys Phe Ser Tyr Arg Asn Ala Lys Asn Asp Asp Leu Trp 
                485                 490                 495     


Ser Ser Leu Ser Asn Ser Cys Leu Glu Ser Asp Phe Thr Ser Gly Gly 
            500                 505                 510         


Val Cys His Ser Asp Pro Lys Met Thr Ser Asn Met Leu Ala Phe Leu 
        515                 520                 525             


Gly Glu Asn Ala Glu Val Lys Glu Met Met Thr Thr Trp Thr Leu Gln 
    530                 535                 540                 


Lys Gly Ile Pro Leu Leu Val Val Lys Gln Asp Gly Cys Ser Leu Arg 
545                 550                 555                 560 


Leu Gln Gln Glu Arg Phe Leu Gln Gly Val Phe Gln Glu Asp Pro Glu 
                565                 570                 575     


Trp Arg Ala Leu Gln Glu Arg Tyr Leu Trp His Ile Pro Leu Thr Tyr 
            580                 585                 590         


Ser Thr Ser Ser Ser Asn Val Ile His Arg His Ile Leu Lys Ser Lys 
        595                 600                 605             


Thr Asp Thr Leu Asp Leu Pro Glu Lys Thr Ser Trp Val Lys Phe Asn 
    610                 615                 620                 


Val Asp Ser Asn Gly Tyr Tyr Ile Val His Tyr Glu Gly His Gly Trp 
625                 630                 635                 640 


Asp Gln Leu Ile Thr Gln Leu Asn Gln Asn His Thr Leu Leu Arg Pro 
                645                 650                 655     


Lys Asp Arg Val Gly Leu Ile His Asp Val Phe Gln Leu Val Gly Ala 
            660                 665                 670         


Gly Arg Leu Thr Leu Asp Lys Ala Leu Asp Met Thr Tyr Tyr Leu Gln 
        675                 680                 685             


His Glu Thr Ser Ser Pro Ala Leu Leu Glu Gly Leu Ser Tyr Leu Glu 
    690                 695                 700                 


Ser Phe Tyr His Met Met Asp Arg Arg Asn Ile Ser Asp Ile Ser Glu 
705                 710                 715                 720 


Asn Leu Lys Arg Tyr Leu Leu Gln Tyr Phe Lys Pro Val Ile Asp Arg 
                725                 730                 735     


Gln Ser Trp Ser Asp Lys Gly Ser Val Trp Asp Arg Met Leu Arg Ser 
            740                 745                 750         


Ala Leu Leu Lys Leu Ala Cys Asp Leu Asn His Ala Pro Cys Ile Gln 
        755                 760                 765             


Lys Ala Ala Glu Leu Phe Ser Gln Trp Met Glu Ser Ser Gly Lys Leu 
    770                 775                 780                 


Asn Ile Pro Thr Asp Val Leu Lys Ile Val Tyr Ser Val Gly Ala Gln 
785                 790                 795                 800 


Thr Thr Ala Gly Trp Asn Tyr Leu Leu Glu Gln Tyr Glu Leu Ser Met 
                805                 810                 815     


Ser Ser Ala Glu Gln Asn Lys Ile Leu Tyr Ala Leu Ser Thr Ser Lys 
            820                 825                 830         


His Gln Glu Lys Leu Leu Lys Leu Ile Glu Leu Gly Met Glu Gly Lys 
        835                 840                 845             


Val Ile Lys Thr Gln Asn Leu Ala Ala Leu Leu His Ala Ile Ala Arg 
    850                 855                 860                 


Arg Pro Lys Gly Gln Gln Leu Ala Trp Asp Phe Val Arg Glu Asn Trp 
865                 870                 875                 880 


Thr His Leu Leu Lys Lys Phe Asp Leu Gly Ser Tyr Asp Ile Arg Met 
                885                 890                 895     


Ile Ile Ser Gly Thr Thr Ala His Phe Ser Ser Lys Asp Lys Leu Gln 
            900                 905                 910         


Glu Val Lys Leu Phe Phe Glu Ser Leu Glu Ala Gln Gly Ser His Leu 
        915                 920                 925             


Asp Ile Phe Gln Thr Val Leu Glu Thr Ile Thr Lys Asn Ile Lys Trp 
    930                 935                 940                 


Leu Glu Lys Asn Leu Pro Thr Leu Arg Thr Trp Leu Met Val Asn Thr 
945                 950                 955                 960 


<210>  3626
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERAS__Homo_sapiens__NP_853510

<400>  3626

Met Glu Leu Pro Thr Lys Pro Gly Thr Phe Asp Leu Gly Leu Ala Thr 
1               5                   10                  15      


Trp Ser Pro Ser Phe Gln Gly Glu Thr His Arg Ala Gln Ala Arg Arg 
            20                  25                  30          


Arg Asp Val Gly Arg Gln Leu Pro Glu Tyr Lys Ala Val Val Val Gly 
        35                  40                  45              


Ala Ser Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Asn His Gln 
    50                  55                  60                  


Cys Phe Val Glu Asp His Asp Pro Thr Ile Gln Asp Ser Tyr Trp Lys 
65                  70                  75                  80  


Glu Leu Thr Leu Asp Ser Gly Asp Cys Ile Leu Asn Val Leu Asp Thr 
                85                  90                  95      


Ala Gly Gln Ala Ile His Arg Ala Leu Arg Asp Gln Cys Leu Ala Val 
            100                 105                 110         


Cys Asp Gly Val Leu Gly Val Phe Ala Leu Asp Asp Pro Ser Ser Leu 
        115                 120                 125             


Ile Gln Leu Gln Gln Ile Trp Ala Thr Trp Gly Pro His Pro Ala Gln 
    130                 135                 140                 


Pro Leu Val Leu Val Gly Asn Lys Cys Asp Leu Val Thr Thr Ala Gly 
145                 150                 155                 160 


Asp Ala His Ala Ala Ala Ala Ala Leu Ala His Ser Trp Gly Ala His 
                165                 170                 175     


Phe Val Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Glu Glu Ala Phe 
            180                 185                 190         


Ser Leu Leu Val His Glu Ile Gln Arg Val Gln Glu Ala Met Ala Lys 
        195                 200                 205             


Glu Pro Met Ala Arg Ser Cys Arg Glu Lys Thr Arg His Gln Lys Ala 
    210                 215                 220                 


Thr Cys His Cys Gly Cys Ser Val Ala 
225                 230             


<210>  3627
<211>  1225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERBB2__Homo_sapiens__NP_001005862

<400>  3627

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  3628
<211>  1302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERBB2IP__Homo_sapiens__NP_001006600

<400>  3628

Met Thr Thr Lys Arg Ser Leu Phe Val Arg Leu Val Pro Cys Arg Cys 
1               5                   10                  15      


Leu Arg Gly Glu Glu Glu Thr Val Thr Thr Leu Asp Tyr Ser His Cys 
            20                  25                  30          


Ser Leu Glu Gln Val Pro Lys Glu Ile Phe Thr Phe Glu Lys Thr Leu 
        35                  40                  45              


Glu Glu Leu Tyr Leu Asp Ala Asn Gln Ile Glu Glu Leu Pro Lys Gln 
    50                  55                  60                  


Leu Phe Asn Cys Gln Ser Leu His Lys Leu Ser Leu Pro Asp Asn Asp 
65                  70                  75                  80  


Leu Thr Thr Leu Pro Ala Ser Ile Ala Asn Leu Ile Asn Leu Arg Glu 
                85                  90                  95      


Leu Asp Val Ser Lys Asn Gly Ile Gln Glu Phe Pro Glu Asn Ile Lys 
            100                 105                 110         


Asn Cys Lys Val Leu Thr Ile Val Glu Ala Ser Val Asn Pro Ile Ser 
        115                 120                 125             


Lys Leu Pro Asp Gly Phe Ser Gln Leu Leu Asn Leu Thr Gln Leu Tyr 
    130                 135                 140                 


Leu Asn Asp Ala Phe Leu Glu Phe Leu Pro Ala Asn Phe Gly Arg Leu 
145                 150                 155                 160 


Thr Lys Leu Gln Ile Leu Glu Leu Arg Glu Asn Gln Leu Lys Met Leu 
                165                 170                 175     


Pro Lys Thr Met Asn Arg Leu Thr Gln Leu Glu Arg Leu Asp Leu Gly 
            180                 185                 190         


Ser Asn Glu Phe Thr Glu Val Pro Glu Val Leu Glu Gln Leu Ser Gly 
        195                 200                 205             


Leu Lys Glu Phe Trp Met Asp Ala Asn Arg Leu Thr Phe Ile Pro Gly 
    210                 215                 220                 


Phe Ile Gly Ser Leu Lys Gln Leu Thr Tyr Leu Asp Val Ser Lys Asn 
225                 230                 235                 240 


Asn Ile Glu Met Val Glu Glu Gly Ile Ser Thr Cys Glu Asn Leu Gln 
                245                 250                 255     


Asp Leu Leu Leu Ser Ser Asn Ser Leu Gln Gln Leu Pro Glu Thr Ile 
            260                 265                 270         


Gly Ser Leu Lys Asn Ile Thr Thr Leu Lys Ile Asp Glu Asn Gln Leu 
        275                 280                 285             


Met Tyr Leu Pro Asp Ser Ile Gly Gly Leu Ile Ser Val Glu Glu Leu 
    290                 295                 300                 


Asp Cys Ser Phe Asn Glu Val Glu Ala Leu Pro Ser Ser Ile Gly Gln 
305                 310                 315                 320 


Leu Thr Asn Leu Arg Thr Phe Ala Ala Asp His Asn Tyr Leu Gln Gln 
                325                 330                 335     


Leu Pro Pro Glu Ile Gly Ser Trp Lys Asn Ile Thr Val Leu Phe Leu 
            340                 345                 350         


His Ser Asn Lys Leu Glu Thr Leu Pro Glu Glu Met Gly Asp Met Gln 
        355                 360                 365             


Lys Leu Lys Val Ile Asn Leu Ser Asp Asn Arg Leu Lys Asn Leu Pro 
    370                 375                 380                 


Phe Ser Phe Thr Lys Leu Gln Gln Leu Thr Ala Met Trp Leu Ser Asp 
385                 390                 395                 400 


Asn Gln Ser Lys Pro Leu Ile Pro Leu Gln Lys Glu Thr Asp Ser Glu 
                405                 410                 415     


Thr Gln Lys Met Val Leu Thr Asn Tyr Met Phe Pro Gln Gln Pro Arg 
            420                 425                 430         


Thr Glu Asp Val Met Phe Ile Ser Asp Asn Glu Ser Phe Asn Pro Ser 
        435                 440                 445             


Leu Trp Glu Glu Gln Arg Lys Gln Arg Ala Gln Val Ala Phe Glu Cys 
    450                 455                 460                 


Asp Glu Asp Lys Asp Glu Arg Glu Ala Pro Pro Arg Glu Gly Asn Leu 
465                 470                 475                 480 


Lys Arg Tyr Pro Thr Pro Tyr Pro Asp Glu Leu Lys Asn Met Val Lys 
                485                 490                 495     


Thr Val Gln Thr Ile Val His Arg Leu Lys Asp Glu Glu Thr Asn Glu 
            500                 505                 510         


Asp Ser Gly Arg Asp Leu Lys Pro His Glu Asp Gln Gln Asp Ile Asn 
        515                 520                 525             


Lys Asp Val Gly Val Lys Thr Ser Glu Ser Thr Thr Thr Val Lys Ser 
    530                 535                 540                 


Lys Val Asp Glu Arg Glu Lys Tyr Met Ile Gly Asn Ser Val Gln Lys 
545                 550                 555                 560 


Ile Ser Glu Pro Glu Ala Glu Ile Ser Pro Gly Ser Leu Pro Val Thr 
                565                 570                 575     


Ala Asn Met Lys Ala Ser Glu Asn Leu Lys His Ile Val Asn His Asp 
            580                 585                 590         


Asp Val Phe Glu Glu Ser Glu Glu Leu Ser Ser Asp Glu Glu Met Lys 
        595                 600                 605             


Met Ala Glu Met Arg Pro Pro Leu Ile Glu Thr Ser Ile Asn Gln Pro 
    610                 615                 620                 


Lys Val Val Ala Leu Ser Asn Asn Lys Lys Asp Asp Thr Lys Glu Thr 
625                 630                 635                 640 


Asp Ser Leu Ser Asp Glu Val Thr His Asn Ser Asn Gln Asn Asn Ser 
                645                 650                 655     


Asn Cys Ser Ser Pro Ser Arg Met Ser Asp Ser Val Ser Leu Asn Thr 
            660                 665                 670         


Asp Ser Ser Gln Asp Thr Ser Leu Cys Ser Pro Val Lys Gln Thr His 
        675                 680                 685             


Ile Asp Ile Asn Ser Lys Ile Arg Gln Glu Asp Glu Asn Phe Asn Ser 
    690                 695                 700                 


Leu Leu Gln Asn Gly Asp Ile Leu Asn Ser Ser Thr Glu Glu Lys Phe 
705                 710                 715                 720 


Lys Ala His Asp Lys Lys Asp Phe Asn Leu Pro Glu Tyr Asp Leu Asn 
                725                 730                 735     


Val Glu Glu Arg Leu Val Leu Ile Glu Lys Ser Val Asp Ser Thr Ala 
            740                 745                 750         


Thr Ala Asp Asp Thr His Lys Leu Asp His Ile Asn Met Asn Leu Asn 
        755                 760                 765             


Lys Leu Ile Thr Asn Asp Thr Phe Gln Pro Glu Ile Met Glu Arg Ser 
    770                 775                 780                 


Lys Thr Gln Asp Ile Val Leu Gly Thr Ser Phe Leu Ser Ile Asn Ser 
785                 790                 795                 800 


Lys Glu Glu Thr Glu His Leu Glu Asn Gly Asn Lys Tyr Pro Asn Leu 
                805                 810                 815     


Glu Ser Val Asn Lys Val Asn Gly His Ser Glu Glu Thr Ser Gln Ser 
            820                 825                 830         


Pro Asn Arg Thr Glu Pro His Asp Ser Asp Cys Ser Val Asp Leu Gly 
        835                 840                 845             


Ile Ser Lys Ser Thr Glu Asp Leu Ser Pro Gln Lys Ser Gly Pro Val 
    850                 855                 860                 


Gly Ser Val Val Lys Ser His Ser Ile Thr Asn Met Glu Ile Gly Gly 
865                 870                 875                 880 


Leu Lys Ile Tyr Asp Ile Leu Ser Asp Asn Gly Pro Gln Gln Pro Ser 
                885                 890                 895     


Thr Thr Val Lys Ile Thr Ser Ala Val Asp Gly Lys Asn Ile Val Arg 
            900                 905                 910         


Ser Lys Ser Ala Thr Leu Leu Tyr Asp Gln Pro Leu Gln Val Phe Thr 
        915                 920                 925             


Gly Ser Ser Ser Ser Ser Asp Leu Ile Ser Gly Thr Lys Ala Ile Phe 
    930                 935                 940                 


Lys Phe Asp Ser Asn His Asn Pro Glu Glu Pro Asn Ile Ile Arg Gly 
945                 950                 955                 960 


Pro Thr Ser Gly Pro Gln Ser Ala Pro Gln Ile Tyr Gly Pro Pro Gln 
                965                 970                 975     


Tyr Asn Ile Gln Tyr Ser Ser Ser Ala Ala Val Lys Asp Thr Leu Trp 
            980                 985                 990         


His Ser Lys Gln Asn Pro Gln Ile  Asp His Ala Ser Phe  Pro Pro Gln 
        995                 1000                 1005             


Leu Leu  Pro Arg Ser Glu Ser  Thr Glu Asn Gln Ser  Tyr Ala Lys 
    1010                 1015                 1020             


His Ser  Ala Asn Met Asn Phe  Ser Asn His Asn Asn  Val Arg Ala 
    1025                 1030                 1035             


Asn Thr  Ala Tyr His Leu His  Gln Arg Leu Gly Pro  Ala Arg His 
    1040                 1045                 1050             


Gly Glu  Met Trp Ala Ile Ser  Pro Asn Asp Arg Leu  Ile Pro Ala 
    1055                 1060                 1065             


Val Thr  Arg Ser Thr Ile Gln  Arg Gln Ser Ser Val  Ser Ser Thr 
    1070                 1075                 1080             


Ala Ser  Val Asn Leu Gly Asp  Pro Gly Ser Thr Arg  Arg Ala Gln 
    1085                 1090                 1095             


Ile Pro  Glu Gly Asp Tyr Leu  Ser Tyr Arg Glu Phe  His Ser Ala 
    1100                 1105                 1110             


Gly Arg  Thr Pro Pro Met Met  Pro Gly Ser Gln Arg  Pro Leu Ser 
    1115                 1120                 1125             


Ala Arg  Thr Tyr Ser Ile Asp  Gly Pro Asn Ala Ser  Arg Pro Gln 
    1130                 1135                 1140             


Ser Ala  Arg Pro Ser Ile Asn  Glu Ile Pro Glu Arg  Thr Met Ser 
    1145                 1150                 1155             


Val Ser  Asp Phe Asn Tyr Ser  Arg Thr Ser Pro Ser  Lys Arg Pro 
    1160                 1165                 1170             


Asn Ala  Arg Val Gly Ser Glu  His Ser Leu Leu Asp  Pro Pro Gly 
    1175                 1180                 1185             


Lys Ser  Lys Val Pro Arg Asp  Trp Arg Glu Gln Val  Leu Arg His 
    1190                 1195                 1200             


Ile Glu  Ala Lys Lys Leu Glu  Lys Ile Arg Val Arg  Val Glu Lys 
    1205                 1210                 1215             


Asp Pro  Glu Leu Gly Phe Ser  Ile Ser Gly Gly Val  Gly Gly Arg 
    1220                 1225                 1230             


Gly Asn  Pro Phe Arg Pro Asp  Asp Asp Gly Ile Phe  Val Thr Arg 
    1235                 1240                 1245             


Val Gln  Pro Glu Gly Pro Ala  Ser Lys Leu Leu Gln  Pro Gly Asp 
    1250                 1255                 1260             


Lys Ile  Ile Gln Ala Asn Gly  Tyr Ser Phe Ile Asn  Ile Glu His 
    1265                 1270                 1275             


Gly Gln  Ala Val Ser Leu Leu  Lys Thr Phe Gln Asn  Thr Val Glu 
    1280                 1285                 1290             


Leu Ile  Ile Val Arg Glu Val  Ser Ser 
    1295                 1300         


<210>  3629
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERBB3__Homo_sapiens__NP_001005915

<400>  3629

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Gly Gln Phe Pro 
    130                 135                 140                 


Met Val Pro Ser Gly Leu Thr Pro Gln Pro Ala Gln Asp Trp Tyr Leu 
145                 150                 155                 160 


Leu Asp Asp Asp Pro Arg Leu Leu Thr Leu Ser Ala Ser Ser Lys Val 
                165                 170                 175     


Pro Val Thr Leu Ala Ala Val 
            180             


<210>  3630
<211>  1292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERBB4__Homo_sapiens__NP_001036064

<400>  3630

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Asn Gln Phe Val Tyr  Arg Asp Gly 
    1040                 1045                 1050             


Gly Phe  Ala Ala Glu Gln Gly  Val Ser Val Pro Tyr  Arg Ala Pro 
    1055                 1060                 1065             


Thr Ser  Thr Ile Pro Glu Ala  Pro Val Ala Gln Gly  Ala Thr Ala 
    1070                 1075                 1080             


Glu Ile  Phe Asp Asp Ser Cys  Cys Asn Gly Thr Leu  Arg Lys Pro 
    1085                 1090                 1095             


Val Ala  Pro His Val Gln Glu  Asp Ser Ser Thr Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Ala Asp  Pro Thr Val Phe Ala  Pro Glu Arg Ser Pro  Arg Gly Glu 
    1115                 1120                 1125             


Leu Asp  Glu Glu Gly Tyr Met  Thr Pro Met Arg Asp  Lys Pro Lys 
    1130                 1135                 1140             


Gln Glu  Tyr Leu Asn Pro Val  Glu Glu Asn Pro Phe  Val Ser Arg 
    1145                 1150                 1155             


Arg Lys  Asn Gly Asp Leu Gln  Ala Leu Asp Asn Pro  Glu Tyr His 
    1160                 1165                 1170             


Asn Ala  Ser Asn Gly Pro Pro  Lys Ala Glu Asp Glu  Tyr Val Asn 
    1175                 1180                 1185             


Glu Pro  Leu Tyr Leu Asn Thr  Phe Ala Asn Thr Leu  Gly Lys Ala 
    1190                 1195                 1200             


Glu Tyr  Leu Lys Asn Asn Ile  Leu Ser Met Pro Glu  Lys Ala Lys 
    1205                 1210                 1215             


Lys Ala  Phe Asp Asn Pro Asp  Tyr Trp Asn His Ser  Leu Pro Pro 
    1220                 1225                 1230             


Arg Ser  Thr Leu Gln His Pro  Asp Tyr Leu Gln Glu  Tyr Ser Thr 
    1235                 1240                 1245             


Lys Tyr  Phe Tyr Lys Gln Asn  Gly Arg Ile Arg Pro  Ile Val Ala 
    1250                 1255                 1260             


Glu Asn  Pro Glu Tyr Leu Ser  Glu Phe Ser Leu Lys  Pro Gly Thr 
    1265                 1270                 1275             


Val Leu  Pro Pro Pro Pro Tyr  Arg His Arg Asn Thr  Val Val 
    1280                 1285                 1290         


<210>  3631
<211>  1151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERC1__Homo_sapiens__XP_011519238

<400>  3631

Met Tyr Gly Ser Ala Arg Ser Val Gly Lys Val Glu Pro Ser Ser Gln 
1               5                   10                  15      


Ser Pro Gly Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His 
            20                  25                  30          


Arg Arg Thr Asn Ser Thr Gly Gly Ser Ser Gly Ser Ser Val Gly Gly 
        35                  40                  45              


Gly Ser Gly Lys Thr Leu Ser Met Glu Asn Ile Gln Ser Leu Asn Ala 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu Ser Asp His Glu Asn Val 
65                  70                  75                  80  


Gly Ser Glu Thr Pro Lys Ser Thr Met Thr Leu Gly Arg Ser Gly Gly 
                85                  90                  95      


Arg Leu Pro Tyr Gly Val Arg Met Thr Ala Met Gly Ser Ser Pro Asn 
            100                 105                 110         


Ile Ala Ser Ser Gly Val Ala Ser Asp Thr Ile Ala Phe Gly Glu His 
        115                 120                 125             


His Leu Pro Pro Val Ser Met Ala Ser Thr Val Pro His Ser Leu Arg 
    130                 135                 140                 


Gln Ala Arg Asp Asn Thr Ile Met Asp Leu Gln Thr Gln Leu Lys Glu 
145                 150                 155                 160 


Val Leu Arg Glu Asn Asp Leu Leu Arg Lys Asp Val Glu Val Lys Glu 
                165                 170                 175     


Ser Lys Leu Ser Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro 
            180                 185                 190         


Glu Leu Lys Lys Glu Arg Ala Leu Arg Lys Asp Glu Ala Ser Lys Ile 
        195                 200                 205             


Thr Ile Trp Lys Glu Gln Tyr Arg Val Val Gln Glu Glu Asn Gln His 
    210                 215                 220                 


Met Gln Met Thr Ile Gln Ala Leu Gln Asp Glu Leu Arg Ile Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Gln Leu Phe Gln Gln Asp Ser Ser Ser Arg Thr Gly Glu 
                245                 250                 255     


Pro Cys Val Ala Glu Leu Thr Glu Glu Asn Phe Gln Arg Leu His Ala 
            260                 265                 270         


Glu His Glu Arg Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu 
        275                 280                 285             


Glu Glu Met Glu Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala 
    290                 295                 300                 


Arg Asp Glu Ser Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly 
305                 310                 315                 320 


Leu Ser Ala Lys Ala Thr Glu Glu Asp His Glu Arg Thr Arg Arg Leu 
                325                 330                 335     


Ala Glu Ala Glu Met His Val His His Leu Glu Ser Leu Leu Glu Gln 
            340                 345                 350         


Lys Glu Lys Glu Asn Ser Met Leu Arg Glu Glu Met His Arg Arg Phe 
        355                 360                 365             


Glu Asn Ala Pro Asp Ser Ala Lys Thr Lys Ala Leu Gln Thr Val Ile 
    370                 375                 380                 


Glu Met Lys Asp Ser Lys Ile Ser Ser Met Glu Arg Gly Leu Arg Asp 
385                 390                 395                 400 


Leu Glu Glu Glu Ile Gln Met Leu Lys Ser Asn Gly Ala Leu Ser Thr 
                405                 410                 415     


Glu Glu Arg Glu Glu Glu Met Lys Gln Met Glu Val Tyr Arg Ser His 
            420                 425                 430         


Ser Lys Phe Met Lys Asn Lys Ile Gly Gln Val Lys Gln Glu Leu Ser 
        435                 440                 445             


Arg Lys Asp Thr Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu 
    450                 455                 460                 


Thr Asn Gln Phe Ser Asp Ser Lys Gln His Ile Glu Val Leu Lys Glu 
465                 470                 475                 480 


Ser Leu Thr Ala Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val 
                485                 490                 495     


Asp Ala Leu Arg Leu Arg Leu Glu Glu Lys Glu Thr Met Leu Asn Lys 
            500                 505                 510         


Lys Thr Lys Gln Ile Gln Asp Met Ala Glu Glu Lys Gly Thr Gln Ala 
        515                 520                 525             


Gly Glu Ile His Asp Leu Lys Asp Met Leu Asp Val Lys Glu Arg Lys 
    530                 535                 540                 


Val Asn Val Leu Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg 
545                 550                 555                 560 


Asp Lys Glu Lys Gln Met Ser Ser Leu Lys Glu Arg Val Lys Ser Leu 
                565                 570                 575     


Gln Ala Asp Thr Thr Asn Thr Asp Thr Ala Leu Thr Thr Leu Glu Glu 
            580                 585                 590         


Ala Leu Ala Glu Lys Glu Arg Thr Ile Glu Arg Leu Lys Glu Gln Arg 
        595                 600                 605             


Asp Arg Asp Glu Arg Glu Lys Gln Glu Glu Ile Asp Asn Tyr Lys Lys 
    610                 615                 620                 


Asp Leu Lys Asp Leu Lys Glu Lys Val Ser Leu Leu Gln Gly Asp Leu 
625                 630                 635                 640 


Ser Glu Lys Glu Ala Ser Leu Leu Asp Leu Lys Glu His Ala Ser Ser 
                645                 650                 655     


Leu Ala Ser Ser Gly Leu Lys Lys Asp Ser Arg Leu Lys Thr Leu Glu 
            660                 665                 670         


Ile Ala Leu Glu Gln Lys Lys Glu Glu Cys Leu Lys Met Glu Ser Gln 
        675                 680                 685             


Leu Lys Lys Ala His Glu Ala Ala Leu Glu Ala Arg Ala Ser Pro Glu 
    690                 695                 700                 


Met Ser Asp Arg Ile Gln His Leu Glu Arg Glu Ile Thr Arg Tyr Lys 
705                 710                 715                 720 


Asp Glu Ser Ser Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile 
                725                 730                 735     


Leu Lys Glu Val Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala 
            740                 745                 750         


Glu Leu Glu Ser Leu Thr Ser Arg Gln Val Lys Asp Gln Asn Lys Lys 
        755                 760                 765             


Val Ala Asn Leu Lys His Lys Glu Gln Val Glu Lys Lys Lys Ser Ala 
    770                 775                 780                 


Gln Met Leu Glu Glu Ala Arg Arg Arg Glu Asp Asn Leu Asn Asp Ser 
785                 790                 795                 800 


Ser Gln Gln Leu Gln Asp Ser Leu Arg Lys Lys Asp Asp Arg Ile Glu 
                805                 810                 815     


Glu Leu Glu Glu Ala Leu Arg Glu Ser Val Gln Ile Thr Ala Glu Arg 
            820                 825                 830         


Glu Met Val Leu Ala Gln Glu Glu Ser Ala Arg Thr Asn Ala Glu Lys 
        835                 840                 845             


Gln Val Glu Glu Leu Leu Met Ala Met Glu Lys Val Lys Gln Glu Leu 
    850                 855                 860                 


Glu Ser Met Lys Ala Lys Leu Ser Ser Thr Gln Gln Ser Leu Ala Glu 
865                 870                 875                 880 


Lys Glu Thr His Leu Thr Asn Leu Arg Ala Glu Arg Arg Lys His Leu 
                885                 890                 895     


Glu Glu Val Leu Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser 
            900                 905                 910         


Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser Ser Ser Lys Lys 
        915                 920                 925             


Lys Thr Gln Glu Glu Val Ala Ala Leu Lys Arg Glu Lys Asp Arg Leu 
    930                 935                 940                 


Val Gln Gln Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala 
945                 950                 955                 960 


Asp Asn Tyr Glu Asp Asp His Phe Lys Ser Ser His Ser Asn Gln Thr 
                965                 970                 975     


Asn His Lys Pro Ser Pro Asp Gln Ile Ile Gln Pro Leu Leu Glu Leu 
            980                 985                 990         


Asp Gln Asn Arg Ser Lys Leu Lys  Leu Tyr Ile Gly His  Leu Thr Thr 
        995                 1000                 1005             


Leu Cys  His Asp Arg Asp Pro  Leu Ile Leu Arg Gly  Leu Thr Pro 
    1010                 1015                 1020             


Pro Ala  Ser Tyr Asn Leu Asp  Asp Asp Gln Ala Ala  Trp Glu Asn 
    1025                 1030                 1035             


Glu Leu  Gln Lys Met Thr Arg  Gly Gln Asn Thr Pro  His Phe Leu 
    1040                 1045                 1050             


Lys Pro  Ala Ser Ala Asn Leu  Trp Pro Asp Lys Asp  Phe Gln Ser 
    1055                 1060                 1065             


Pro Ser  Val His Leu Leu Leu  Gln Asp Cys Thr Ser  Ser Lys His 
    1070                 1075                 1080             


Ser Thr  Gln Lys Glu Ser Val  Ala Ser Gln Ser His  Gly Lys Thr 
    1085                 1090                 1095             


Ala Phe  Phe His Val Met Leu  Met Leu Gln Asp Glu  Leu Glu Lys 
    1100                 1105                 1110             


Gly Glu  Arg Asp Asn Ala Glu  Leu Gln Glu Phe Ala  Asn Ala Ile 
    1115                 1120                 1125             


Leu Gln  Gln Ile Ala Asp His  Cys Pro Asp Ile Leu  Glu Gln Val 
    1130                 1135                 1140             


Val Asn  Ala Leu Glu Glu Ser  Ser 
    1145                 1150     


<210>  3632
<211>  957
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERC2__Homo_sapiens__NP_056391

<400>  3632

Met Tyr Gly Ser Ala Arg Thr Ile Thr Asn Leu Glu Gly Ser Pro Ser 
1               5                   10                  15      


Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His Arg Arg Thr 
            20                  25                  30          


Ser Ser Gly Gly Gly Gly Gly Thr Gly Lys Thr Leu Ser Met Glu Asn 
        35                  40                  45              


Ile Gln Ser Leu Asn Ala Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu 
    50                  55                  60                  


Ser Asp His Glu Gly Val Ala Ser Thr Thr Tyr Pro Lys Gly Thr Met 
65                  70                  75                  80  


Thr Leu Gly Arg Ala Thr Asn Arg Ala Val Tyr Gly Gly Arg Val Thr 
                85                  90                  95      


Ala Met Gly Ser Ser Pro Asn Ile Ala Ser Ala Gly Leu Ser His Thr 
            100                 105                 110         


Asp Val Leu Ser Tyr Thr Asp Gln His Gly Gly Leu Thr Gly Ser Ser 
        115                 120                 125             


His His His His His Gln Val Pro Ser Met Leu Arg Gln Val Arg Asp 
    130                 135                 140                 


Ser Thr Met Leu Asp Leu Gln Ala Gln Leu Lys Glu Leu Gln Arg Glu 
145                 150                 155                 160 


Asn Asp Leu Leu Arg Lys Glu Leu Asp Ile Lys Asp Ser Lys Leu Gly 
                165                 170                 175     


Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro Glu Leu Lys Lys 
            180                 185                 190         


Glu Arg Val Leu Arg Lys Glu Glu Ala Ala Arg Met Ser Val Leu Lys 
        195                 200                 205             


Glu Gln Met Arg Val Ser His Glu Glu Asn Gln His Leu Gln Leu Thr 
    210                 215                 220                 


Ile Gln Ala Leu Gln Asp Glu Leu Arg Thr Gln Arg Asp Leu Asn His 
225                 230                 235                 240 


Leu Leu Gln Gln Glu Ser Gly Asn Arg Gly Ala Glu His Phe Thr Ile 
                245                 250                 255     


Glu Leu Thr Glu Glu Asn Phe Arg Arg Leu Gln Ala Glu His Asp Arg 
            260                 265                 270         


Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu Glu Glu Met Glu 
        275                 280                 285             


Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala Arg Asp Glu Ser 
    290                 295                 300                 


Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly Leu Pro Ser Lys 
305                 310                 315                 320 


Ser Leu Glu Asp Asp Asn Glu Arg Thr Arg Arg Met Ala Glu Ala Glu 
                325                 330                 335     


Ser Gln Val Ser His Leu Glu Val Ile Leu Asp Gln Lys Glu Lys Glu 
            340                 345                 350         


Asn Ile His Leu Arg Glu Glu Leu His Arg Arg Ser Gln Leu Gln Pro 
        355                 360                 365             


Glu Pro Ala Lys Thr Lys Ala Leu Gln Thr Val Ile Glu Met Lys Asp 
    370                 375                 380                 


Thr Lys Ile Ala Ser Leu Glu Arg Asn Ile Arg Asp Leu Glu Asp Glu 
385                 390                 395                 400 


Ile Gln Met Leu Lys Ala Asn Gly Val Leu Asn Thr Glu Asp Arg Glu 
                405                 410                 415     


Glu Glu Ile Lys Gln Ile Glu Val Tyr Lys Ser His Ser Lys Phe Met 
            420                 425                 430         


Lys Thr Lys Ile Asp Gln Leu Lys Gln Glu Leu Ser Lys Lys Glu Ser 
        435                 440                 445             


Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu Ser Asn Gln Asn 
    450                 455                 460                 


Ser Asp Cys Lys Gln His Ile Glu Val Leu Lys Glu Ser Leu Thr Ala 
465                 470                 475                 480 


Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val Asp Ala Leu Arg 
                485                 490                 495     


Leu Arg Leu Glu Glu Lys Glu Ser Phe Leu Asn Lys Lys Thr Lys Gln 
            500                 505                 510         


Leu Gln Asp Leu Thr Glu Glu Lys Gly Thr Leu Ala Gly Glu Ile Arg 
        515                 520                 525             


Asp Met Lys Asp Met Leu Glu Val Lys Glu Arg Lys Ile Asn Val Leu 
    530                 535                 540                 


Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg Asp Lys Asp Lys 
545                 550                 555                 560 


Gln Leu Thr Asn Leu Lys Asp Arg Val Lys Ser Leu Gln Thr Asp Ser 
                565                 570                 575     


Ser Asn Thr Asp Thr Ala Leu Ala Thr Leu Glu Glu Ala Leu Ser Glu 
            580                 585                 590         


Lys Glu Arg Ile Ile Glu Arg Leu Lys Glu Gln Arg Glu Arg Asp Asp 
        595                 600                 605             


Arg Glu Arg Leu Glu Glu Ile Glu Ser Phe Arg Lys Glu Asn Lys Asp 
    610                 615                 620                 


Leu Lys Glu Lys Val Asn Ala Leu Gln Ala Glu Leu Thr Glu Lys Glu 
625                 630                 635                 640 


Ser Ser Leu Ile Asp Leu Lys Glu His Ala Ser Ser Leu Ala Ser Ala 
                645                 650                 655     


Gly Leu Lys Arg Asp Ser Lys Leu Lys Ser Leu Glu Ile Ala Ile Glu 
            660                 665                 670         


Gln Lys Lys Glu Glu Cys Ser Lys Leu Glu Ala Gln Leu Lys Lys Ala 
        675                 680                 685             


His Asn Ile Glu Asp Asp Ser Arg Met Asn Pro Glu Phe Ala Asp Gln 
    690                 695                 700                 


Ile Lys Gln Leu Asp Lys Glu Ala Ser Tyr Tyr Arg Asp Glu Cys Gly 
705                 710                 715                 720 


Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile Leu Lys Glu Val 
                725                 730                 735     


Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala Glu Leu Glu Ser 
            740                 745                 750         


Leu Thr Leu Arg His Met Lys Asp Gln Asn Lys Lys Val Ala Asn Leu 
        755                 760                 765             


Lys His Asn Gln Gln Leu Glu Lys Lys Lys Asn Ala Gln Leu Leu Glu 
    770                 775                 780                 


Glu Val Arg Arg Arg Glu Asp Ser Met Ala Asp Asn Ser Gln His Leu 
785                 790                 795                 800 


Gln Ile Glu Glu Leu Met Asn Ala Leu Glu Lys Thr Arg Gln Glu Leu 
                805                 810                 815     


Asp Ala Thr Lys Ala Arg Leu Ala Ser Thr Gln Gln Ser Leu Ala Glu 
            820                 825                 830         


Lys Glu Ala His Leu Ala Asn Leu Arg Ile Glu Arg Arg Lys Gln Leu 
        835                 840                 845             


Glu Glu Ile Leu Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser 
    850                 855                 860                 


Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser Ala Ser Lys Lys 
865                 870                 875                 880 


Lys Lys Thr Gln Glu Glu Val Met Ala Leu Lys Arg Glu Lys Asp Arg 
                885                 890                 895     


Leu Val His Gln Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met 
            900                 905                 910         


Ala Asp Asn Tyr Asp Asp Asp His His His Tyr His His His His His 
        915                 920                 925             


His His His His Arg Ser Pro Gly Arg Ser Gln His Ser Asn His Arg 
    930                 935                 940                 


Pro Ser Pro Asp Gln Asp Asp Glu Glu Gly Ile Trp Ala 
945                 950                 955         


<210>  3633
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC1__Homo_sapiens__NP_001159521

<400>  3633

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Ser Leu Glu Gln Leu Ile 
225                 230                 235                 240 


Ala Ala Ser Arg Glu Asp Leu Ala Leu Cys Pro Gly Leu Gly Pro Gln 
                245                 250                 255     


Lys Ala Arg Arg Leu Phe Asp Val Leu His Glu Pro Phe Leu Lys Val 
            260                 265                 270         


Pro 
    


<210>  3634
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC2__Homo_sapiens__NP_000391

<400>  3634

Met Lys Leu Asn Val Asp Gly Leu Leu Val Tyr Phe Pro Tyr Asp Tyr 
1               5                   10                  15      


Ile Tyr Pro Glu Gln Phe Ser Tyr Met Arg Glu Leu Lys Arg Thr Leu 
            20                  25                  30          


Asp Ala Lys Gly His Gly Val Leu Glu Met Pro Ser Gly Thr Gly Lys 
        35                  40                  45              


Thr Val Ser Leu Leu Ala Leu Ile Met Ala Tyr Gln Arg Ala Tyr Pro 
    50                  55                  60                  


Leu Glu Val Thr Lys Leu Ile Tyr Cys Ser Arg Thr Val Pro Glu Ile 
65                  70                  75                  80  


Glu Lys Val Ile Glu Glu Leu Arg Lys Leu Leu Asn Phe Tyr Glu Lys 
                85                  90                  95      


Gln Glu Gly Glu Lys Leu Pro Phe Leu Gly Leu Ala Leu Ser Ser Arg 
            100                 105                 110         


Lys Asn Leu Cys Ile His Pro Glu Val Thr Pro Leu Arg Phe Gly Lys 
        115                 120                 125             


Asp Val Asp Gly Lys Cys His Ser Leu Thr Ala Ser Tyr Val Arg Ala 
    130                 135                 140                 


Gln Tyr Gln His Asp Thr Ser Leu Pro His Cys Arg Phe Tyr Glu Glu 
145                 150                 155                 160 


Phe Asp Ala His Gly Arg Glu Val Pro Leu Pro Ala Gly Ile Tyr Asn 
                165                 170                 175     


Leu Asp Asp Leu Lys Ala Leu Gly Arg Arg Gln Gly Trp Cys Pro Tyr 
            180                 185                 190         


Phe Leu Ala Arg Tyr Ser Ile Leu His Ala Asn Val Val Val Tyr Ser 
        195                 200                 205             


Tyr His Tyr Leu Leu Asp Pro Lys Ile Ala Asp Leu Val Ser Lys Glu 
    210                 215                 220                 


Leu Ala Arg Lys Ala Val Val Val Phe Asp Glu Ala His Asn Ile Asp 
225                 230                 235                 240 


Asn Val Cys Ile Asp Ser Met Ser Val Asn Leu Thr Arg Arg Thr Leu 
                245                 250                 255     


Asp Arg Cys Gln Gly Asn Leu Glu Thr Leu Gln Lys Thr Val Leu Arg 
            260                 265                 270         


Ile Lys Glu Thr Asp Glu Gln Arg Leu Arg Asp Glu Tyr Arg Arg Leu 
        275                 280                 285             


Val Glu Gly Leu Arg Glu Ala Ser Ala Ala Arg Glu Thr Asp Ala His 
    290                 295                 300                 


Leu Ala Asn Pro Val Leu Pro Asp Glu Val Leu Gln Glu Ala Val Pro 
305                 310                 315                 320 


Gly Ser Ile Arg Thr Ala Glu His Phe Leu Gly Phe Leu Arg Arg Leu 
                325                 330                 335     


Leu Glu Tyr Val Lys Trp Arg Leu Arg Val Gln His Val Val Gln Glu 
            340                 345                 350         


Ser Pro Pro Ala Phe Leu Ser Gly Leu Ala Gln Arg Val Cys Ile Gln 
        355                 360                 365             


Arg Lys Pro Leu Arg Phe Cys Ala Glu Arg Leu Arg Ser Leu Leu His 
    370                 375                 380                 


Thr Leu Glu Ile Thr Asp Leu Ala Asp Phe Ser Pro Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Asn Phe Ala Thr Leu Val Ser Thr Tyr Ala Lys Gly Phe Thr Ile 
                405                 410                 415     


Ile Ile Glu Pro Phe Asp Asp Arg Thr Pro Thr Ile Ala Asn Pro Ile 
            420                 425                 430         


Leu His Phe Ser Cys Met Asp Ala Ser Leu Ala Ile Lys Pro Val Phe 
        435                 440                 445             


Glu Arg Phe Gln Ser Val Ile Ile Thr Ser Gly Thr Leu Ser Pro Leu 
    450                 455                 460                 


Asp Ile Tyr Pro Lys Ile Leu Asp Phe His Pro Val Thr Met Ala Thr 
465                 470                 475                 480 


Phe Thr Met Thr Leu Ala Arg Val Cys Leu Cys Pro Met Ile Ile Gly 
                485                 490                 495     


Arg Gly Asn Asp Gln Val Ala Ile Ser Ser Lys Phe Glu Thr Arg Glu 
            500                 505                 510         


Asp Ile Ala Val Ile Arg Asn Tyr Gly Asn Leu Leu Leu Glu Met Ser 
        515                 520                 525             


Ala Val Val Pro Asp Gly Ile Val Ala Phe Phe Thr Ser Tyr Gln Tyr 
    530                 535                 540                 


Met Glu Ser Thr Val Ala Ser Trp Tyr Glu Gln Gly Ile Leu Glu Asn 
545                 550                 555                 560 


Ile Gln Arg Asn Lys Leu Leu Phe Ile Glu Thr Gln Asp Gly Ala Glu 
                565                 570                 575     


Thr Ser Val Ala Leu Glu Lys Tyr Gln Glu Ala Cys Glu Asn Gly Arg 
            580                 585                 590         


Gly Ala Ile Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu Gly Ile 
        595                 600                 605             


Asp Phe Val His His Tyr Gly Arg Ala Val Ile Met Phe Gly Val Pro 
    610                 615                 620                 


Tyr Val Tyr Thr Gln Ser Arg Ile Leu Lys Ala Arg Leu Glu Tyr Leu 
625                 630                 635                 640 


Arg Asp Gln Phe Gln Ile Arg Glu Asn Asp Phe Leu Thr Phe Asp Ala 
                645                 650                 655     


Met Arg His Ala Ala Gln Cys Val Gly Arg Ala Ile Arg Gly Lys Thr 
            660                 665                 670         


Asp Tyr Gly Leu Met Val Phe Ala Asp Lys Arg Phe Ala Arg Gly Asp 
        675                 680                 685             


Lys Arg Gly Lys Leu Pro Arg Trp Ile Gln Glu His Leu Thr Asp Ala 
    690                 695                 700                 


Asn Leu Asn Leu Thr Val Asp Glu Gly Val Gln Val Ala Lys Tyr Phe 
705                 710                 715                 720 


Leu Arg Gln Met Ala Gln Pro Phe His Arg Glu Asp Gln Leu Gly Leu 
                725                 730                 735     


Ser Leu Leu Ser Leu Glu Gln Leu Glu Ser Glu Glu Thr Leu Lys Arg 
            740                 745                 750         


Ile Glu Gln Ile Ala Gln Gln Leu 
        755                 760 


<210>  3635
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC3__Homo_sapiens__NP_000113

<400>  3635

Met Gly Lys Arg Asp Arg Ala Asp Arg Asp Lys Lys Lys Ser Arg Lys 
1               5                   10                  15      


Arg His Tyr Glu Asp Glu Glu Asp Asp Glu Glu Asp Ala Pro Gly Asn 
            20                  25                  30          


Asp Pro Gln Glu Ala Val Pro Ser Ala Ala Gly Lys Gln Val Asp Glu 
        35                  40                  45              


Ser Gly Thr Lys Val Asp Glu Tyr Gly Ala Lys Asp Tyr Arg Leu Gln 
    50                  55                  60                  


Met Pro Leu Lys Asp Asp His Thr Ser Arg Pro Leu Trp Val Ala Pro 
65                  70                  75                  80  


Asp Gly His Ile Phe Leu Glu Ala Phe Ser Pro Val Tyr Lys Tyr Ala 
                85                  90                  95      


Gln Asp Phe Leu Val Ala Ile Ala Glu Pro Val Cys Arg Pro Thr His 
            100                 105                 110         


Val His Glu Tyr Lys Leu Thr Ala Tyr Ser Leu Tyr Ala Ala Val Ser 
        115                 120                 125             


Val Gly Leu Gln Thr Ser Asp Ile Thr Glu Tyr Leu Arg Lys Leu Ser 
    130                 135                 140                 


Lys Thr Gly Val Pro Asp Gly Ile Met Gln Phe Ile Lys Leu Cys Thr 
145                 150                 155                 160 


Val Ser Tyr Gly Lys Val Lys Leu Val Leu Lys His Asn Arg Tyr Phe 
                165                 170                 175     


Val Glu Ser Cys His Pro Asp Val Ile Gln His Leu Leu Gln Asp Pro 
            180                 185                 190         


Val Ile Arg Glu Cys Arg Leu Arg Asn Ser Glu Gly Glu Ala Thr Glu 
        195                 200                 205             


Leu Ile Thr Glu Thr Phe Thr Ser Lys Ser Ala Ile Ser Lys Thr Ala 
    210                 215                 220                 


Glu Ser Ser Gly Gly Pro Ser Thr Ser Arg Val Thr Asp Pro Gln Gly 
225                 230                 235                 240 


Lys Ser Asp Ile Pro Met Asp Leu Phe Asp Phe Tyr Glu Gln Met Asp 
                245                 250                 255     


Lys Asp Glu Glu Glu Glu Glu Glu Thr Gln Thr Val Ser Phe Glu Val 
            260                 265                 270         


Lys Gln Glu Met Ile Glu Glu Leu Gln Lys Arg Cys Ile His Leu Glu 
        275                 280                 285             


Tyr Pro Leu Leu Ala Glu Tyr Asp Phe Arg Asn Asp Ser Val Asn Pro 
    290                 295                 300                 


Asp Ile Asn Ile Asp Leu Lys Pro Thr Ala Val Leu Arg Pro Tyr Gln 
305                 310                 315                 320 


Glu Lys Ser Leu Arg Lys Met Phe Gly Asn Gly Arg Ala Arg Ser Gly 
                325                 330                 335     


Val Ile Val Leu Pro Cys Gly Ala Gly Lys Ser Leu Val Gly Val Thr 
            340                 345                 350         


Ala Ala Cys Thr Val Arg Lys Arg Cys Leu Val Leu Gly Asn Ser Ala 
        355                 360                 365             


Val Ser Val Glu Gln Trp Lys Ala Gln Phe Lys Met Trp Ser Thr Ile 
    370                 375                 380                 


Asp Asp Ser Gln Ile Cys Arg Phe Thr Ser Asp Ala Lys Asp Lys Pro 
385                 390                 395                 400 


Ile Gly Cys Ser Val Ala Ile Ser Thr Tyr Ser Met Leu Gly His Thr 
                405                 410                 415     


Thr Lys Arg Ser Trp Glu Ala Glu Arg Val Met Glu Trp Leu Lys Thr 
            420                 425                 430         


Gln Glu Trp Gly Leu Met Ile Leu Asp Glu Val His Thr Ile Pro Ala 
        435                 440                 445             


Lys Met Phe Arg Arg Val Leu Thr Ile Val Gln Ala His Cys Lys Leu 
    450                 455                 460                 


Gly Leu Thr Ala Thr Leu Val Arg Glu Asp Asp Lys Ile Val Asp Leu 
465                 470                 475                 480 


Asn Phe Leu Ile Gly Pro Lys Leu Tyr Glu Ala Asn Trp Met Glu Leu 
                485                 490                 495     


Gln Asn Asn Gly Tyr Ile Ala Lys Val Gln Cys Ala Glu Val Trp Cys 
            500                 505                 510         


Pro Met Ser Pro Glu Phe Tyr Arg Glu Tyr Val Ala Ile Lys Thr Lys 
        515                 520                 525             


Lys Arg Ile Leu Leu Tyr Thr Met Asn Pro Asn Lys Phe Arg Ala Cys 
    530                 535                 540                 


Gln Phe Leu Ile Lys Phe His Glu Arg Arg Asn Asp Lys Ile Ile Val 
545                 550                 555                 560 


Phe Ala Asp Asn Val Phe Ala Leu Lys Glu Tyr Ala Ile Arg Leu Asn 
                565                 570                 575     


Lys Pro Tyr Ile Tyr Gly Pro Thr Ser Gln Gly Glu Arg Met Gln Ile 
            580                 585                 590         


Leu Gln Asn Phe Lys His Asn Pro Lys Ile Asn Thr Ile Phe Ile Ser 
        595                 600                 605             


Lys Val Gly Asp Thr Ser Phe Asp Leu Pro Glu Ala Asn Val Leu Ile 
    610                 615                 620                 


Gln Ile Ser Ser His Gly Gly Ser Arg Arg Gln Glu Ala Gln Arg Leu 
625                 630                 635                 640 


Gly Arg Val Leu Arg Ala Lys Lys Gly Met Val Ala Glu Glu Tyr Asn 
                645                 650                 655     


Ala Phe Phe Tyr Ser Leu Val Ser Gln Asp Thr Gln Glu Met Ala Tyr 
            660                 665                 670         


Ser Thr Lys Arg Gln Arg Phe Leu Val Asp Gln Gly Tyr Ser Phe Lys 
        675                 680                 685             


Val Ile Thr Lys Leu Ala Gly Met Glu Glu Glu Asp Leu Ala Phe Ser 
    690                 695                 700                 


Thr Lys Glu Glu Gln Gln Gln Leu Leu Gln Lys Val Leu Ala Ala Thr 
705                 710                 715                 720 


Asp Leu Asp Ala Glu Glu Glu Val Val Ala Gly Glu Phe Gly Ser Arg 
                725                 730                 735     


Ser Ser Gln Ala Ser Arg Arg Phe Gly Thr Met Ser Ser Met Ser Gly 
            740                 745                 750         


Ala Asp Asp Thr Val Tyr Met Glu Tyr His Ser Ser Arg Ser Lys Ala 
        755                 760                 765             


Pro Ser Lys His Val His Pro Leu Phe Lys Arg Phe Arg Lys 
    770                 775                 780         


<210>  3636
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC4__Homo_sapiens__NP_005227

<400>  3636

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 
    130                 135                 140                 


Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 
145                 150                 155                 160 


Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 
                165                 170                 175     


His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 
            180                 185                 190         


Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 
        195                 200                 205             


Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 
    210                 215                 220                 


Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 
225                 230                 235                 240 


Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 
                245                 250                 255     


Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 
            260                 265                 270         


Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 
        275                 280                 285             


Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 
    290                 295                 300                 


Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 
305                 310                 315                 320 


Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 
                325                 330                 335     


Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 
            340                 345                 350         


Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Glu 
        355                 360                 365             


Thr Lys Lys Glu Leu Val Leu Glu Ser Asn Pro Lys Trp Glu Ala Leu 
    370                 375                 380                 


Thr Glu Val Leu Lys Glu Ile Glu Ala Glu Asn Lys Glu Ser Glu Ala 
385                 390                 395                 400 


Leu Gly Gly Pro Gly Gln Val Leu Ile Cys Ala Ser Asp Asp Arg Thr 
                405                 410                 415     


Cys Ser Gln Leu Arg Asp Tyr Ile Thr Leu Gly Ala Glu Ala Phe Leu 
            420                 425                 430         


Leu Arg Leu Tyr Arg Lys Thr Phe Glu Lys Asp Ser Lys Ala Glu Glu 
        435                 440                 445             


Val Trp Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys 
    450                 455                 460                 


Ser His Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Glu Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln 
                485                 490                 495     


Met Val Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu 
            500                 505                 510         


Gly Tyr Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu 
        515                 520                 525             


Ile Lys His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe 
    530                 535                 540                 


Gly Ile Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys 
545                 550                 555                 560 


Ser Asp Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg 
                565                 570                 575     


Tyr Val Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu 
            580                 585                 590         


Ile Tyr Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu 
        595                 600                 605             


Ile Tyr Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg 
    610                 615                 620                 


Lys Glu Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met 
625                 630                 635                 640 


Val Val Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu 
                645                 650                 655     


Val Arg Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala 
            660                 665                 670         


Gly Gly Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met 
        675                 680                 685             


Arg Glu Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile 
    690                 695                 700                 


Asp Ile Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro 
705                 710                 715                 720 


Glu Met Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu 
                725                 730                 735     


Asn Asn Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr 
            740                 745                 750         


Lys Arg Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser 
        755                 760                 765             


Leu Thr Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile 
    770                 775                 780                 


Ser Ser Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile 
785                 790                 795                 800 


Leu Trp Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu 
                805                 810                 815     


Lys Gln Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr 
            820                 825                 830         


Ala Asp Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro 
        835                 840                 845             


Gln Asp Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg 
    850                 855                 860                 


Ser Leu Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser 
865                 870                 875                 880 


Gln Asp Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln 
                885                 890                 895     


Leu Tyr Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly 
            900                 905                 910         


Lys Gly Lys Lys 
        915     


<210>  3637
<211>  1186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC5__Homo_sapiens__NP_000114

<400>  3637

Met Gly Val Gln Gly Leu Trp Lys Leu Leu Glu Cys Ser Gly Arg Gln 
1               5                   10                  15      


Val Ser Pro Glu Ala Leu Glu Gly Lys Ile Leu Ala Val Asp Ile Ser 
            20                  25                  30          


Ile Trp Leu Asn Gln Ala Leu Lys Gly Val Arg Asp Arg His Gly Asn 
        35                  40                  45              


Ser Ile Glu Asn Pro His Leu Leu Thr Leu Phe His Arg Leu Cys Lys 
    50                  55                  60                  


Leu Leu Phe Phe Arg Ile Arg Pro Ile Phe Val Phe Asp Gly Asp Ala 
65                  70                  75                  80  


Pro Leu Leu Lys Lys Gln Thr Leu Val Lys Arg Arg Gln Arg Lys Asp 
                85                  90                  95      


Leu Ala Ser Ser Asp Ser Arg Lys Thr Thr Glu Lys Leu Leu Lys Thr 
            100                 105                 110         


Phe Leu Lys Arg Gln Ala Ile Lys Thr Ala Phe Arg Ser Lys Arg Asp 
        115                 120                 125             


Glu Ala Leu Pro Ser Leu Thr Gln Val Arg Arg Glu Asn Asp Leu Tyr 
    130                 135                 140                 


Val Leu Pro Pro Leu Gln Glu Glu Glu Lys His Ser Ser Glu Glu Glu 
145                 150                 155                 160 


Asp Glu Lys Glu Trp Gln Glu Arg Met Asn Gln Lys Gln Ala Leu Gln 
                165                 170                 175     


Glu Glu Phe Phe His Asn Pro Gln Ala Ile Asp Ile Glu Ser Glu Asp 
            180                 185                 190         


Phe Ser Ser Leu Pro Pro Glu Val Lys His Glu Ile Leu Thr Asp Met 
        195                 200                 205             


Lys Glu Phe Thr Lys Arg Arg Arg Thr Leu Phe Glu Ala Met Pro Glu 
    210                 215                 220                 


Glu Ser Asp Asp Phe Ser Gln Tyr Gln Leu Lys Gly Leu Leu Lys Lys 
225                 230                 235                 240 


Asn Tyr Leu Asn Gln His Ile Glu His Val Gln Lys Glu Met Asn Gln 
                245                 250                 255     


Gln His Ser Gly His Ile Arg Arg Gln Tyr Glu Asp Glu Gly Gly Phe 
            260                 265                 270         


Leu Lys Glu Val Glu Ser Arg Arg Val Val Ser Glu Asp Thr Ser His 
        275                 280                 285             


Tyr Ile Leu Ile Lys Gly Ile Gln Ala Lys Thr Val Ala Glu Val Asp 
    290                 295                 300                 


Ser Glu Ser Leu Pro Ser Ser Ser Lys Met His Gly Met Ser Phe Asp 
305                 310                 315                 320 


Val Lys Ser Ser Pro Cys Glu Lys Leu Lys Thr Glu Lys Glu Pro Asp 
                325                 330                 335     


Ala Thr Pro Pro Ser Pro Arg Thr Leu Leu Ala Met Gln Ala Ala Leu 
            340                 345                 350         


Leu Gly Ser Ser Ser Glu Glu Glu Leu Glu Ser Glu Asn Arg Arg Gln 
        355                 360                 365             


Ala Arg Gly Arg Asn Ala Pro Ala Ala Val Asp Glu Gly Ser Ile Ser 
    370                 375                 380                 


Pro Arg Thr Leu Ser Ala Ile Lys Arg Ala Leu Asp Asp Asp Glu Asp 
385                 390                 395                 400 


Val Lys Val Cys Ala Gly Asp Asp Val Gln Thr Gly Gly Pro Gly Ala 
                405                 410                 415     


Glu Glu Met Arg Ile Asn Ser Ser Thr Glu Asn Ser Asp Glu Gly Leu 
            420                 425                 430         


Lys Val Arg Asp Gly Lys Gly Ile Pro Phe Thr Ala Thr Leu Ala Ser 
        435                 440                 445             


Ser Ser Val Asn Ser Ala Glu Glu His Val Ala Ser Thr Asn Glu Gly 
    450                 455                 460                 


Arg Glu Pro Thr Asp Ser Val Pro Lys Glu Gln Met Ser Leu Val His 
465                 470                 475                 480 


Val Gly Thr Glu Ala Phe Pro Ile Ser Asp Glu Ser Met Ile Lys Asp 
                485                 490                 495     


Arg Lys Asp Arg Leu Pro Leu Glu Ser Ala Val Val Arg His Ser Asp 
            500                 505                 510         


Ala Pro Gly Leu Pro Asn Gly Arg Glu Leu Thr Pro Ala Ser Pro Thr 
        515                 520                 525             


Cys Thr Asn Ser Val Ser Lys Asn Glu Thr His Ala Glu Val Leu Glu 
    530                 535                 540                 


Gln Gln Asn Glu Leu Cys Pro Tyr Glu Ser Lys Phe Asp Ser Ser Leu 
545                 550                 555                 560 


Leu Ser Ser Asp Asp Glu Thr Lys Cys Lys Pro Asn Ser Ala Ser Glu 
                565                 570                 575     


Val Ile Gly Pro Val Ser Leu Gln Glu Thr Ser Ser Ile Val Ser Val 
            580                 585                 590         


Pro Ser Glu Ala Val Asp Asn Val Glu Asn Val Val Ser Phe Asn Ala 
        595                 600                 605             


Lys Glu His Glu Asn Phe Leu Glu Thr Ile Gln Glu Gln Gln Thr Thr 
    610                 615                 620                 


Glu Ser Ala Gly Gln Asp Leu Ile Ser Ile Pro Lys Ala Val Glu Pro 
625                 630                 635                 640 


Met Glu Ile Asp Ser Glu Glu Ser Glu Ser Asp Gly Ser Phe Ile Glu 
                645                 650                 655     


Val Gln Ser Val Ile Ser Asp Glu Glu Leu Gln Ala Glu Phe Pro Glu 
            660                 665                 670         


Thr Ser Lys Pro Pro Ser Glu Gln Gly Glu Glu Glu Leu Val Gly Thr 
        675                 680                 685             


Arg Glu Gly Glu Ala Pro Ala Glu Ser Glu Ser Leu Leu Arg Asp Asn 
    690                 695                 700                 


Ser Glu Arg Asp Asp Val Asp Gly Glu Pro Gln Glu Ala Glu Lys Asp 
705                 710                 715                 720 


Ala Glu Asp Ser Leu His Glu Trp Gln Asp Ile Asn Leu Glu Glu Leu 
                725                 730                 735     


Glu Thr Leu Glu Ser Asn Leu Leu Ala Gln Gln Asn Ser Leu Lys Ala 
            740                 745                 750         


Gln Lys Gln Gln Gln Glu Arg Ile Ala Ala Thr Val Thr Gly Gln Met 
        755                 760                 765             


Phe Leu Glu Ser Gln Glu Leu Leu Arg Leu Phe Gly Ile Pro Tyr Ile 
    770                 775                 780                 


Gln Ala Pro Met Glu Ala Glu Ala Gln Cys Ala Ile Leu Asp Leu Thr 
785                 790                 795                 800 


Asp Gln Thr Ser Gly Thr Ile Thr Asp Asp Ser Asp Ile Trp Leu Phe 
                805                 810                 815     


Gly Ala Arg His Val Tyr Arg Asn Phe Phe Asn Lys Asn Lys Phe Val 
            820                 825                 830         


Glu Tyr Tyr Gln Tyr Val Asp Phe His Asn Gln Leu Gly Leu Asp Arg 
        835                 840                 845             


Asn Lys Leu Ile Asn Leu Ala Tyr Leu Leu Gly Ser Asp Tyr Thr Glu 
    850                 855                 860                 


Gly Ile Pro Thr Val Gly Cys Val Thr Ala Met Glu Ile Leu Asn Glu 
865                 870                 875                 880 


Phe Pro Gly His Gly Leu Glu Pro Leu Leu Lys Phe Ser Glu Trp Trp 
                885                 890                 895     


His Glu Ala Gln Lys Asn Pro Lys Ile Arg Pro Asn Pro His Asp Thr 
            900                 905                 910         


Lys Val Lys Lys Lys Leu Arg Thr Leu Gln Leu Thr Pro Gly Phe Pro 
        915                 920                 925             


Asn Pro Ala Val Ala Glu Ala Tyr Leu Lys Pro Val Val Asp Asp Ser 
    930                 935                 940                 


Lys Gly Ser Phe Leu Trp Gly Lys Pro Asp Leu Asp Lys Ile Arg Glu 
945                 950                 955                 960 


Phe Cys Gln Arg Tyr Phe Gly Trp Asn Arg Thr Lys Thr Asp Glu Ser 
                965                 970                 975     


Leu Phe Pro Val Leu Lys Gln Leu Asp Ala Gln Gln Thr Gln Leu Arg 
            980                 985                 990         


Ile Asp Ser Phe Phe Arg Leu Ala  Gln Gln Glu Lys Glu  Asp Ala Lys 
        995                 1000                 1005             


Arg Ile  Lys Ser Gln Arg Leu  Asn Arg Ala Val Thr  Cys Met Leu 
    1010                 1015                 1020             


Arg Lys  Glu Lys Glu Ala Ala  Ala Ser Glu Ile Glu  Ala Val Ser 
    1025                 1030                 1035             


Val Ala  Met Glu Lys Glu Phe  Glu Leu Leu Asp Lys  Ala Lys Arg 
    1040                 1045                 1050             


Lys Thr  Gln Lys Arg Gly Ile  Thr Asn Thr Leu Glu  Glu Ser Ser 
    1055                 1060                 1065             


Ser Leu  Lys Arg Lys Arg Leu  Ser Asp Ser Lys Arg  Lys Asn Thr 
    1070                 1075                 1080             


Cys Gly  Gly Phe Leu Gly Glu  Thr Cys Leu Ser Glu  Ser Ser Asp 
    1085                 1090                 1095             


Gly Ser  Ser Ser Glu Asp Ala  Glu Ser Ser Ser Leu  Met Asn Val 
    1100                 1105                 1110             


Gln Arg  Arg Thr Ala Ala Lys  Glu Pro Lys Thr Ser  Ala Ser Asp 
    1115                 1120                 1125             


Ser Gln  Asn Ser Val Lys Glu  Ala Pro Val Lys Asn  Gly Gly Ala 
    1130                 1135                 1140             


Thr Thr  Ser Ser Ser Ser Asp  Ser Asp Asp Asp Gly  Gly Lys Glu 
    1145                 1150                 1155             


Lys Met  Val Leu Val Thr Ala  Arg Ser Val Phe Gly  Lys Lys Arg 
    1160                 1165                 1170             


Arg Lys  Leu Arg Arg Ala Arg  Gly Arg Lys Arg Lys  Thr 
    1175                 1180                 1185     


<210>  3638
<211>  1493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC6__Homo_sapiens__NP_000115

<400>  3638

Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp 
1               5                   10                  15      


Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys 
            20                  25                  30          


Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg 
        35                  40                  45              


Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala 
    50                  55                  60                  


Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile 
65                  70                  75                  80  


Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly 
                85                  90                  95      


Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln 
            100                 105                 110         


Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp 
        115                 120                 125             


Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr 
    130                 135                 140                 


Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln 
145                 150                 155                 160 


Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg 
                165                 170                 175     


Gln Lys Tyr Asn Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln 
            180                 185                 190         


Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu 
        195                 200                 205             


Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu 
    210                 215                 220                 


Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile 
225                 230                 235                 240 


Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln 
                245                 250                 255     


Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu 
            260                 265                 270         


Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln 
        275                 280                 285             


Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro 
    290                 295                 300                 


Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val 
305                 310                 315                 320 


Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln 
                325                 330                 335     


Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg 
            340                 345                 350         


Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu 
        355                 360                 365             


Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr 
385                 390                 395                 400 


Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys 
                405                 410                 415     


Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu 
            420                 425                 430         


Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys 
        435                 440                 445             


Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg 
    450                 455                 460                 


Leu Arg Arg Trp Asn Lys Leu Arg Leu Gln Asp Lys Glu Lys Arg Leu 
465                 470                 475                 480 


Lys Leu Glu Asp Asp Ser Glu Glu Ser Asp Ala Glu Phe Asp Glu Gly 
                485                 490                 495     


Phe Lys Val Pro Gly Phe Leu Phe Lys Lys Leu Phe Lys Tyr Gln Gln 
            500                 505                 510         


Thr Gly Val Arg Trp Leu Trp Glu Leu His Cys Gln Gln Ala Gly Gly 
        515                 520                 525             


Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ile Ile Ala 
    530                 535                 540                 


Phe Leu Ala Gly Leu Ser Tyr Ser Lys Ile Arg Thr Arg Gly Ser Asn 
545                 550                 555                 560 


Tyr Arg Phe Glu Gly Leu Gly Pro Thr Val Ile Val Cys Pro Thr Thr 
                565                 570                 575     


Val Met His Gln Trp Val Lys Glu Phe His Thr Trp Trp Pro Pro Phe 
            580                 585                 590         


Arg Val Ala Ile Leu His Glu Thr Gly Ser Tyr Thr His Lys Lys Glu 
        595                 600                 605             


Lys Leu Ile Arg Asp Val Ala His Cys His Gly Ile Leu Ile Thr Ser 
    610                 615                 620                 


Tyr Ser Tyr Ile Arg Leu Met Gln Asp Asp Ile Ser Arg Tyr Asp Trp 
625                 630                 635                 640 


His Tyr Val Ile Leu Asp Glu Gly His Lys Ile Arg Asn Pro Asn Ala 
                645                 650                 655     


Ala Val Thr Leu Ala Cys Lys Gln Phe Arg Thr Pro His Arg Ile Ile 
            660                 665                 670         


Leu Ser Gly Ser Pro Met Gln Asn Asn Leu Arg Glu Leu Trp Ser Leu 
        675                 680                 685             


Phe Asp Phe Ile Phe Pro Gly Lys Leu Gly Thr Leu Pro Val Phe Met 
    690                 695                 700                 


Glu Gln Phe Ser Val Pro Ile Thr Met Gly Gly Tyr Ser Asn Ala Ser 
705                 710                 715                 720 


Pro Val Gln Val Lys Thr Ala Tyr Lys Cys Ala Cys Val Leu Arg Asp 
                725                 730                 735     


Thr Ile Asn Pro Tyr Leu Leu Arg Arg Met Lys Ser Asp Val Lys Met 
            740                 745                 750         


Ser Leu Ser Leu Pro Asp Lys Asn Glu Gln Val Leu Phe Cys Arg Leu 
        755                 760                 765             


Thr Asp Glu Gln His Lys Val Tyr Gln Asn Phe Val Asp Ser Lys Glu 
    770                 775                 780                 


Val Tyr Arg Ile Leu Asn Gly Glu Met Gln Ile Phe Ser Gly Leu Ile 
785                 790                 795                 800 


Ala Leu Arg Lys Ile Cys Asn His Pro Asp Leu Phe Ser Gly Gly Pro 
                805                 810                 815     


Lys Asn Leu Lys Gly Leu Pro Asp Asp Glu Leu Glu Glu Asp Gln Phe 
            820                 825                 830         


Gly Tyr Trp Lys Arg Ser Gly Lys Met Ile Val Val Glu Ser Leu Leu 
        835                 840                 845             


Lys Ile Trp His Lys Gln Gly Gln Arg Val Leu Leu Phe Ser Gln Ser 
    850                 855                 860                 


Arg Gln Met Leu Asp Ile Leu Glu Val Phe Leu Arg Ala Gln Lys Tyr 
865                 870                 875                 880 


Thr Tyr Leu Lys Met Asp Gly Thr Thr Thr Ile Ala Ser Arg Gln Pro 
                885                 890                 895     


Leu Ile Thr Arg Tyr Asn Glu Asp Thr Ser Ile Phe Val Phe Leu Leu 
            900                 905                 910         


Thr Thr Arg Val Gly Gly Leu Gly Val Asn Leu Thr Gly Ala Asn Arg 
        915                 920                 925             


Val Val Ile Tyr Asp Pro Asp Trp Asn Pro Ser Thr Asp Thr Gln Ala 
    930                 935                 940                 


Arg Glu Arg Ala Trp Arg Ile Gly Gln Lys Lys Gln Val Thr Val Tyr 
945                 950                 955                 960 


Arg Leu Leu Thr Ala Gly Thr Ile Glu Glu Lys Ile Tyr His Arg Gln 
                965                 970                 975     


Ile Phe Lys Gln Phe Leu Thr Asn Arg Val Leu Lys Asp Pro Lys Gln 
            980                 985                 990         


Arg Arg Phe Phe Lys Ser Asn Asp  Leu Tyr Glu Leu Phe  Thr Leu Thr 
        995                 1000                 1005             


Ser Pro  Asp Ala Ser Gln Ser  Thr Glu Thr Ser Ala  Ile Phe Ala 
    1010                 1015                 1020             


Gly Thr  Gly Ser Asp Val Gln  Thr Pro Lys Cys His  Leu Lys Arg 
    1025                 1030                 1035             


Arg Ile  Gln Pro Ala Phe Gly  Ala Asp His Asp Val  Pro Lys Arg 
    1040                 1045                 1050             


Lys Lys  Phe Pro Ala Ser Asn  Ile Ser Val Asn Asp  Ala Thr Ser 
    1055                 1060                 1065             


Ser Glu  Glu Lys Ser Glu Ala  Lys Gly Ala Glu Val  Asn Ala Val 
    1070                 1075                 1080             


Thr Ser  Asn Arg Ser Asp Pro  Leu Lys Asp Asp Pro  His Met Ser 
    1085                 1090                 1095             


Ser Asn  Val Thr Ser Asn Asp  Arg Leu Gly Glu Glu  Thr Asn Ala 
    1100                 1105                 1110             


Val Ser  Gly Pro Glu Glu Leu  Ser Val Ile Ser Gly  Asn Gly Glu 
    1115                 1120                 1125             


Cys Ser  Asn Ser Ser Gly Thr  Gly Lys Thr Ser Met  Pro Ser Gly 
    1130                 1135                 1140             


Asp Glu  Ser Ile Asp Glu Lys  Leu Gly Leu Ser Tyr  Lys Arg Glu 
    1145                 1150                 1155             


Arg Pro  Ser Gln Ala Gln Thr  Glu Ala Phe Trp Glu  Asn Lys Gln 
    1160                 1165                 1170             


Met Glu  Asn Asn Phe Tyr Lys  His Lys Ser Lys Thr  Lys His His 
    1175                 1180                 1185             


Ser Val  Ala Glu Glu Glu Thr  Leu Glu Lys His Leu  Arg Pro Lys 
    1190                 1195                 1200             


Gln Lys  Pro Lys Asn Ser Lys  His Cys Arg Asp Ala  Lys Phe Glu 
    1205                 1210                 1215             


Gly Thr  Arg Ile Pro His Leu  Val Lys Lys Arg Arg  Tyr Gln Lys 
    1220                 1225                 1230             


Gln Asp  Ser Glu Asn Lys Ser  Glu Ala Lys Glu Gln  Ser Asn Asp 
    1235                 1240                 1245             


Asp Tyr  Val Leu Glu Lys Leu  Phe Lys Lys Ser Val  Gly Val His 
    1250                 1255                 1260             


Ser Val  Met Lys His Asp Ala  Ile Met Asp Gly Ala  Ser Pro Asp 
    1265                 1270                 1275             


Tyr Val  Leu Val Glu Ala Glu  Ala Asn Arg Val Ala  Gln Asp Ala 
    1280                 1285                 1290             


Leu Lys  Ala Leu Arg Leu Ser  Arg Gln Arg Cys Leu  Gly Ala Val 
    1295                 1300                 1305             


Ser Gly  Val Pro Thr Trp Thr  Gly His Arg Gly Ile  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Gly Lys Lys Ser Arg  Phe Gly Lys Lys Arg  Asn Ser Asn 
    1325                 1330                 1335             


Phe Ser  Val Gln His Pro Ser  Ser Thr Ser Pro Thr  Glu Lys Cys 
    1340                 1345                 1350             


Gln Asp  Gly Ile Met Lys Lys  Glu Gly Lys Asp Asn  Val Pro Glu 
    1355                 1360                 1365             


His Phe  Ser Gly Arg Ala Glu  Asp Ala Asp Ser Ser  Ser Gly Pro 
    1370                 1375                 1380             


Leu Ala  Ser Ser Ser Leu Leu  Ala Lys Met Arg Ala  Arg Asn His 
    1385                 1390                 1395             


Leu Ile  Leu Pro Glu Arg Leu  Glu Ser Glu Ser Gly  His Leu Gln 
    1400                 1405                 1410             


Glu Ala  Ser Ala Leu Leu Pro  Thr Thr Glu His Asp  Asp Leu Leu 
    1415                 1420                 1425             


Val Glu  Met Arg Asn Phe Ile  Ala Phe Gln Ala His  Thr Asp Gly 
    1430                 1435                 1440             


Gln Ala  Ser Thr Arg Glu Ile  Leu Gln Glu Phe Glu  Ser Lys Leu 
    1445                 1450                 1455             


Ser Ala  Ser Gln Ser Cys Val  Phe Arg Glu Leu Leu  Arg Asn Leu 
    1460                 1465                 1470             


Cys Thr  Phe His Arg Thr Ser  Gly Gly Glu Gly Ile  Trp Lys Leu 
    1475                 1480                 1485             


Lys Pro  Glu Tyr Cys 
    1490             


<210>  3639
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC6L2__Homo_sapiens__NP_001010895

<400>  3639

Met Gln Pro Gly Ser Ala Pro Pro Pro Gly Arg Met Asp Pro Ser Ala 
1               5                   10                  15      


Pro Gln Pro Arg Ala Glu Thr Ser Gly Lys Asp Ile Trp His Pro Gly 
            20                  25                  30          


Glu Arg Cys Leu Ala Pro Ser Pro Asp Asn Gly Lys Leu Cys Glu Ala 
        35                  40                  45              


Ser Ile Lys Ser Ile Thr Val Asp Glu Asn Gly Lys Ser Phe Ala Val 
    50                  55                  60                  


Val Leu Tyr Ala Asp Phe Gln Glu Arg Lys Ile Pro Leu Lys Gln Leu 
65                  70                  75                  80  


Gln Glu Val Lys Phe Val Lys Asp Cys Pro Arg Asn Leu Ile Phe Asp 
                85                  90                  95      


Asp Glu Asp Leu Glu Lys Pro Tyr Phe Pro Asn Arg Lys Phe Pro Ser 
            100                 105                 110         


Ser Ser Val Ala Phe Lys Leu Ser Asp Asn Gly Asp Ser Ile Pro Tyr 
        115                 120                 125             


Thr Ile Asn Arg Tyr Leu Arg Asp Tyr Gln Arg Glu Gly Thr Arg Phe 
    130                 135                 140                 


Leu Tyr Gly His Tyr Ile His Gly Gly Gly Cys Ile Leu Gly Asp Asp 
145                 150                 155                 160 


Met Gly Leu Gly Lys Thr Val Gln Val Ile Ser Phe Leu Ala Ala Val 
                165                 170                 175     


Leu His Lys Lys Gly Thr Arg Glu Asp Ile Glu Asn Asn Met Pro Glu 
            180                 185                 190         


Phe Leu Leu Arg Ser Met Lys Lys Glu Pro Leu Ser Ser Thr Ala Lys 
        195                 200                 205             


Lys Met Phe Leu Ile Val Ala Pro Leu Ser Val Leu Tyr Asn Trp Lys 
    210                 215                 220                 


Asp Glu Leu Asp Thr Trp Gly Tyr Phe Arg Val Thr Val Leu His Gly 
225                 230                 235                 240 


Asn Arg Lys Asp Asn Glu Leu Ile Arg Val Lys Gln Arg Lys Cys Glu 
                245                 250                 255     


Ile Ala Leu Thr Thr Tyr Glu Thr Leu Arg Leu Cys Leu Asp Glu Leu 
            260                 265                 270         


Asn Ser Leu Glu Trp Ser Ala Val Ile Val Asp Glu Ala His Arg Ile 
        275                 280                 285             


Lys Asn Pro Lys Ala Arg Val Thr Glu Val Met Lys Ala Leu Lys Cys 
    290                 295                 300                 


Asn Val Arg Ile Gly Leu Thr Gly Thr Ile Leu Gln Asn Asn Met Lys 
305                 310                 315                 320 


Glu Leu Trp Cys Val Met Asp Trp Ala Val Pro Gly Leu Leu Gly Ser 
                325                 330                 335     


Gly Thr Tyr Phe Lys Lys Gln Phe Ser Asp Pro Val Glu His Gly Gln 
            340                 345                 350         


Arg His Thr Ala Thr Lys Arg Glu Leu Ala Thr Gly Arg Lys Ala Met 
        355                 360                 365             


Gln Arg Leu Ala Lys Lys Met Ser Gly Trp Phe Leu Arg Arg Thr Lys 
    370                 375                 380                 


Thr Leu Ile Lys Asp Gln Leu Pro Lys Lys Glu Asp Arg Met Val Tyr 
385                 390                 395                 400 


Cys Ser Leu Thr Asp Phe Gln Lys Ala Val Tyr Gln Thr Val Leu Glu 
                405                 410                 415     


Thr Glu Asp Val Thr Leu Ile Leu Gln Ser Ser Glu Pro Cys Thr Cys 
            420                 425                 430         


Arg Ser Gly Gln Lys Arg Arg Asn Cys Cys Tyr Lys Thr Asn Ser His 
        435                 440                 445             


Gly Glu Thr Val Lys Thr Leu Tyr Leu Ser Tyr Leu Thr Val Leu Gln 
    450                 455                 460                 


Lys Val Ala Asn His Val Ala Leu Leu Gln Ala Ala Ser Thr Ser Lys 
465                 470                 475                 480 


Gln Gln Glu Thr Leu Ile Lys Arg Ile Cys Asp Gln Val Phe Ser Arg 
                485                 490                 495     


Phe Pro Asp Phe Val Gln Lys Ser Lys Asp Ala Ala Phe Glu Thr Leu 
            500                 505                 510         


Ser Asp Pro Lys Tyr Ser Gly Lys Met Lys Val Leu Gln Gln Leu Leu 
        515                 520                 525             


Asn His Cys Arg Lys Asn Arg Asp Lys Val Leu Leu Phe Ser Phe Ser 
    530                 535                 540                 


Thr Lys Leu Leu Asp Val Leu Gln Gln Tyr Cys Met Ala Ser Gly Leu 
545                 550                 555                 560 


Asp Tyr Arg Arg Leu Asp Gly Ser Thr Lys Ser Glu Glu Arg Leu Lys 
                565                 570                 575     


Ile Val Lys Glu Phe Asn Ser Thr Gln Asp Val Asn Ile Cys Leu Val 
            580                 585                 590         


Ser Thr Met Ala Gly Gly Leu Gly Leu Asn Phe Val Gly Ala Asn Val 
        595                 600                 605             


Val Val Leu Phe Asp Pro Thr Trp Asn Pro Ala Asn Asp Leu Gln Ala 
    610                 615                 620                 


Ile Asp Arg Ala Tyr Arg Ile Gly Gln Cys Arg Asp Val Lys Val Leu 
625                 630                 635                 640 


Arg Leu Ile Ser Leu Gly Thr Val Glu Glu Ile Met Tyr Leu Arg Gln 
                645                 650                 655     


Ile Tyr Lys Gln Gln Leu His Cys Val Val Val Gly Ser Glu Asn Ala 
            660                 665                 670         


Lys Arg Tyr Phe Glu Ala Val Gln Gly Ser Lys Glu His Gln Gly Glu 
        675                 680                 685             


Leu Phe Gly Ile His Asn Leu Phe Lys Phe Arg Ser Gln Gly Ser Cys 
    690                 695                 700                 


Leu Thr Lys Asp Ile Leu Glu Val 
705                 710         


<210>  3640
<211>  1061
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC6-PGBD3__Homo_sapiens__NP_001263988

<400>  3640

Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp 
1               5                   10                  15      


Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys 
            20                  25                  30          


Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg 
        35                  40                  45              


Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala 
    50                  55                  60                  


Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile 
65                  70                  75                  80  


Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly 
                85                  90                  95      


Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln 
            100                 105                 110         


Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp 
        115                 120                 125             


Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr 
    130                 135                 140                 


Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln 
145                 150                 155                 160 


Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg 
                165                 170                 175     


Gln Lys Tyr Asn Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln 
            180                 185                 190         


Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu 
        195                 200                 205             


Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu 
    210                 215                 220                 


Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile 
225                 230                 235                 240 


Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln 
                245                 250                 255     


Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu 
            260                 265                 270         


Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln 
        275                 280                 285             


Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro 
    290                 295                 300                 


Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val 
305                 310                 315                 320 


Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln 
                325                 330                 335     


Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg 
            340                 345                 350         


Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu 
        355                 360                 365             


Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr 
385                 390                 395                 400 


Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys 
                405                 410                 415     


Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu 
            420                 425                 430         


Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys 
        435                 440                 445             


Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg 
    450                 455                 460                 


Leu Ser Pro Lys Met Pro Arg Thr Leu Ser Leu His Glu Ile Thr Asp 
465                 470                 475                 480 


Leu Leu Glu Thr Asp Asp Ser Ile Glu Ala Ser Ala Ile Val Ile Gln 
                485                 490                 495     


Pro Pro Glu Asn Ala Thr Ala Pro Val Ser Asp Glu Glu Ser Gly Asp 
            500                 505                 510         


Glu Glu Gly Gly Thr Ile Asn Asn Leu Pro Gly Ser Leu Leu His Thr 
        515                 520                 525             


Ala Ala Tyr Leu Ile Gln Asp Gly Ser Asp Ala Glu Ser Asp Ser Asp 
    530                 535                 540                 


Asp Pro Ser Tyr Ala Pro Lys Asp Asp Ser Pro Asp Glu Val Pro Ser 
545                 550                 555                 560 


Thr Phe Thr Val Gln Gln Pro Pro Pro Ser Arg Arg Arg Lys Met Thr 
                565                 570                 575     


Lys Ile Leu Cys Lys Trp Lys Lys Ala Asp Leu Thr Val Gln Pro Val 
            580                 585                 590         


Ala Gly Arg Val Thr Ala Pro Pro Asn Asp Phe Phe Thr Val Met Arg 
        595                 600                 605             


Thr Pro Thr Glu Ile Leu Glu Leu Phe Leu Asp Asp Glu Val Ile Glu 
    610                 615                 620                 


Leu Ile Val Lys Tyr Ser Asn Leu Tyr Ala Cys Ser Lys Gly Val His 
625                 630                 635                 640 


Leu Gly Leu Thr Ser Ser Glu Phe Lys Cys Phe Leu Gly Ile Ile Phe 
                645                 650                 655     


Leu Ser Gly Tyr Val Ser Val Pro Arg Arg Arg Met Phe Trp Glu Gln 
            660                 665                 670         


Arg Thr Asp Val His Asn Val Leu Val Ser Ala Ala Met Arg Arg Asp 
        675                 680                 685             


Arg Phe Glu Thr Ile Phe Ser Asn Leu His Val Ala Asp Asn Ala Asn 
    690                 695                 700                 


Leu Asp Pro Val Asp Lys Phe Ser Lys Leu Arg Pro Leu Ile Ser Lys 
705                 710                 715                 720 


Leu Asn Glu Arg Cys Met Lys Phe Val Pro Asn Glu Thr Tyr Phe Ser 
                725                 730                 735     


Phe Asp Glu Phe Met Val Pro Tyr Phe Gly Arg His Gly Cys Lys Gln 
            740                 745                 750         


Phe Ile Arg Gly Lys Pro Ile Arg Phe Gly Tyr Lys Phe Trp Cys Gly 
        755                 760                 765             


Ala Thr Cys Leu Gly Tyr Ile Cys Trp Phe Gln Pro Tyr Gln Gly Lys 
    770                 775                 780                 


Asn Pro Asn Thr Lys His Glu Glu Tyr Gly Val Gly Ala Ser Leu Val 
785                 790                 795                 800 


Leu Gln Phe Ser Glu Ala Leu Thr Glu Ala His Pro Gly Gln Tyr His 
                805                 810                 815     


Phe Val Phe Asn Asn Phe Phe Thr Ser Ile Ala Leu Leu Asp Lys Leu 
            820                 825                 830         


Ser Ser Met Gly His Gln Ala Thr Gly Thr Val Arg Lys Asp His Ile 
        835                 840                 845             


Asp Arg Val Pro Leu Glu Ser Asp Val Ala Leu Lys Lys Lys Glu Arg 
    850                 855                 860                 


Gly Thr Phe Asp Tyr Arg Ile Asp Gly Lys Gly Asn Ile Val Cys Arg 
865                 870                 875                 880 


Trp Asn Asp Asn Ser Val Val Thr Val Ala Ser Ser Gly Ala Gly Ile 
                885                 890                 895     


His Pro Leu Cys Leu Val Ser Arg Tyr Ser Gln Lys Leu Lys Lys Lys 
            900                 905                 910         


Ile Gln Val Gln Gln Pro Asn Met Ile Lys Val Tyr Asn Gln Phe Met 
        915                 920                 925             


Gly Gly Val Asp Arg Ala Asp Glu Asn Ile Asp Lys Tyr Arg Ala Ser 
    930                 935                 940                 


Ile Arg Gly Lys Lys Trp Tyr Ser Ser Pro Leu Leu Phe Cys Phe Glu 
945                 950                 955                 960 


Leu Val Leu Gln Asn Ala Trp Gln Leu His Lys Thr Tyr Asp Glu Lys 
                965                 970                 975     


Pro Val Asp Phe Leu Glu Phe Arg Arg Arg Val Val Cys His Tyr Leu 
            980                 985                 990         


Glu Thr His Gly His Pro Pro Glu  Pro Gly Gln Lys Gly  Arg Pro Gln 
        995                 1000                 1005             


Lys Arg  Asn Ile Asp Ser Arg  Tyr Asp Gly Ile Asn  His Val Ile 
    1010                 1015                 1020             


Val Lys  Gln Gly Lys Gln Thr  Arg Cys Ala Glu Cys  His Lys Asn 
    1025                 1030                 1035             


Thr Thr  Phe Arg Cys Glu Lys  Cys Asp Val Ala Leu  His Val Lys 
    1040                 1045                 1050             


Cys Ser  Val Glu Tyr His Thr  Glu 
    1055                 1060     


<210>  3641
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERCC8__Homo_sapiens__NP_000073

<400>  3641

Met Leu Gly Phe Leu Ser Ala Arg Gln Thr Gly Leu Glu Asp Pro Leu 
1               5                   10                  15      


Arg Leu Arg Arg Ala Glu Ser Thr Arg Arg Val Leu Gly Leu Glu Leu 
            20                  25                  30          


Asn Lys Asp Arg Asp Val Glu Arg Ile His Gly Gly Gly Ile Asn Thr 
        35                  40                  45              


Leu Asp Ile Glu Pro Val Glu Gly Arg Tyr Met Leu Ser Gly Gly Ser 
    50                  55                  60                  


Asp Gly Val Ile Val Leu Tyr Asp Leu Glu Asn Ser Ser Arg Gln Ser 
65                  70                  75                  80  


Tyr Tyr Thr Cys Lys Ala Val Cys Ser Ile Gly Arg Asp His Pro Asp 
                85                  90                  95      


Val His Arg Tyr Ser Val Glu Thr Val Gln Trp Tyr Pro His Asp Thr 
            100                 105                 110         


Gly Met Phe Thr Ser Ser Ser Phe Asp Lys Thr Leu Lys Val Trp Asp 
        115                 120                 125             


Thr Asn Thr Leu Gln Thr Ala Asp Val Phe Asn Phe Glu Glu Thr Val 
    130                 135                 140                 


Tyr Ser His His Met Ser Pro Val Ser Thr Lys His Cys Leu Val Ala 
145                 150                 155                 160 


Val Gly Thr Arg Gly Pro Lys Val Gln Leu Cys Asp Leu Lys Ser Gly 
                165                 170                 175     


Ser Cys Ser His Ile Leu Gln Gly His Arg Gln Glu Ile Leu Ala Val 
            180                 185                 190         


Ser Trp Ser Pro Arg Tyr Asp Tyr Ile Leu Ala Thr Ala Ser Ala Asp 
        195                 200                 205             


Ser Arg Val Lys Leu Trp Asp Val Arg Arg Ala Ser Gly Cys Leu Ile 
    210                 215                 220                 


Thr Leu Asp Gln His Asn Gly Lys Lys Ser Gln Ala Val Glu Ser Ala 
225                 230                 235                 240 


Asn Thr Ala His Asn Gly Lys Val Asn Gly Leu Cys Phe Thr Ser Asp 
                245                 250                 255     


Gly Leu His Leu Leu Thr Val Gly Thr Asp Asn Arg Met Arg Leu Trp 
            260                 265                 270         


Asn Ser Ser Asn Gly Glu Asn Thr Leu Val Asn Tyr Gly Lys Val Cys 
        275                 280                 285             


Asn Asn Ser Lys Lys Gly Leu Lys Phe Thr Val Ser Cys Gly Cys Ser 
    290                 295                 300                 


Ser Glu Phe Val Phe Val Pro Tyr Gly Ser Thr Ile Ala Val Tyr Thr 
305                 310                 315                 320 


Val Tyr Ser Gly Glu Gln Ile Thr Met Leu Lys Gly His Tyr Lys Thr 
                325                 330                 335     


Val Asp Cys Cys Val Phe Gln Ser Asn Phe Gln Glu Leu Tyr Ser Gly 
            340                 345                 350         


Ser Arg Asp Cys Asn Ile Leu Ala Trp Val Pro Ser Leu Tyr Glu Pro 
        355                 360                 365             


Val Pro Asp Asp Asp Glu Thr Thr Thr Lys Ser Gln Leu Asn Pro Ala 
    370                 375                 380                 


Phe Glu Asp Ala Trp Ser Ser Ser Asp Glu Glu Gly 
385                 390                 395     


<210>  3642
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EREG__Homo_sapiens__NP_001423

<400>  3642

Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 
1               5                   10                  15      


Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 
            20                  25                  30          


Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 
        35                  40                  45              


Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 
    50                  55                  60                  


Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 
65                  70                  75                  80  


Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 
                85                  90                  95      


Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 
            100                 105                 110         


Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 
        115                 120                 125             


Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 
    130                 135                 140                 


Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 
145                 150                 155                 160 


Ser Gly Asp Pro Glu Leu Pro Gln Val 
                165                 


<210>  3643
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERF__Homo_sapiens__NP_001287964

<400>  3643

Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asn Lys 
1               5                   10                  15      


Arg Ile Leu His Lys Thr Lys Gly Lys Arg Phe Thr Tyr Lys Phe Asn 
            20                  25                  30          


Phe Asn Lys Leu Val Leu Val Asn Tyr Pro Phe Ile Asp Val Gly Leu 
        35                  40                  45              


Ala Gly Gly Ala Val Pro Gln Ser Ala Pro Pro Val Pro Ser Gly Gly 
    50                  55                  60                  


Ser His Phe Arg Phe Pro Pro Ser Thr Pro Ser Glu Val Leu Ser Pro 
65                  70                  75                  80  


Thr Glu Asp Pro Arg Ser Pro Pro Ala Cys Ser Ser Ser Ser Ser Ser 
                85                  90                  95      


Leu Phe Ser Ala Val Val Ala Arg Arg Leu Gly Arg Gly Ser Val Ser 
            100                 105                 110         


Asp Cys Ser Asp Gly Thr Ser Glu Leu Glu Glu Pro Leu Gly Glu Asp 
        115                 120                 125             


Pro Arg Ala Arg Pro Pro Gly Pro Pro Asp Leu Gly Ala Phe Arg Gly 
    130                 135                 140                 


Pro Pro Leu Ala Arg Leu Pro His Asp Pro Gly Val Phe Arg Val Tyr 
145                 150                 155                 160 


Pro Arg Pro Arg Gly Gly Pro Glu Pro Leu Ser Pro Phe Pro Val Ser 
                165                 170                 175     


Pro Leu Ala Gly Pro Gly Ser Leu Leu Pro Pro Gln Leu Ser Pro Ala 
            180                 185                 190         


Leu Pro Met Thr Pro Thr His Leu Ala Tyr Thr Pro Ser Pro Thr Leu 
        195                 200                 205             


Ser Pro Met Tyr Pro Ser Gly Gly Gly Gly Pro Ser Gly Ser Gly Gly 
    210                 215                 220                 


Gly Ser His Phe Ser Phe Ser Pro Glu Asp Met Lys Arg Tyr Leu Gln 
225                 230                 235                 240 


Ala His Thr Gln Ser Val Tyr Asn Tyr His Leu Ser Pro Arg Ala Phe 
                245                 250                 255     


Leu His Tyr Pro Gly Leu Val Val Pro Gln Pro Gln Arg Pro Asp Lys 
            260                 265                 270         


Cys Pro Leu Pro Pro Met Ala Pro Glu Thr Pro Pro Val Pro Ser Ser 
        275                 280                 285             


Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Phe Lys Phe Lys Leu 
    290                 295                 300                 


Gln Pro Pro Pro Leu Gly Arg Arg Gln Arg Ala Ala Gly Glu Lys Ala 
305                 310                 315                 320 


Val Ala Gly Ala Asp Lys Ser Gly Gly Ser Ala Gly Gly Leu Ala Glu 
                325                 330                 335     


Gly Ala Gly Ala Leu Ala Pro Pro Pro Pro Pro Pro Gln Ile Lys Val 
            340                 345                 350         


Glu Pro Ile Ser Glu Gly Glu Ser Glu Glu Val Glu Val Thr Asp Ile 
        355                 360                 365             


Ser Asp Glu Asp Glu Glu Asp Gly Glu Val Phe Lys Thr Pro Arg Ala 
    370                 375                 380                 


Pro Pro Ala Pro Pro Lys Pro Glu Pro Gly Glu Ala Pro Gly Ala Ser 
385                 390                 395                 400 


Gln Cys Met Pro Leu Lys Leu Arg Phe Lys Arg Arg Trp Ser Glu Asp 
                405                 410                 415     


Cys Arg Leu Glu Gly Gly Gly Gly Pro Ala Gly Gly Phe Glu Asp Glu 
            420                 425                 430         


Gly Glu Asp Lys Lys Val Arg Gly Glu Gly Pro Gly Glu Ala Gly Gly 
        435                 440                 445             


Pro Leu Thr Pro Arg Arg Val Ser Ser Asp Leu Gln His Ala Thr Ala 
    450                 455                 460                 


Gln Leu Ser Leu Glu His Arg Asp Ser 
465                 470             


<210>  3644
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERG__Homo_sapiens__NP_001129626

<400>  3644

Met Ile Gln Thr Val Pro Asp Pro Ala Ala His Ile Lys Glu Ala Leu 
1               5                   10                  15      


Ser Val Val Ser Glu Asp Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr 
            20                  25                  30          


Pro His Leu Ala Lys Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr 
        35                  40                  45              


Gly Gln Thr Ser Lys Met Ser Pro Arg Val Pro Gln Gln Asp Trp Leu 
    50                  55                  60                  


Ser Gln Pro Pro Ala Arg Val Thr Ile Lys Met Glu Cys Asn Pro Ser 
65                  70                  75                  80  


Gln Val Asn Gly Ser Arg Asn Ser Pro Asp Glu Cys Ser Val Ala Lys 
                85                  90                  95      


Gly Gly Lys Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly 
            100                 105                 110         


Ser Tyr Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn 
        115                 120                 125             


Glu Arg Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp 
    130                 135                 140                 


His Val Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro 
145                 150                 155                 160 


Asp Val Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys 
                165                 170                 175     


Lys Met Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala 
            180                 185                 190         


Asp Ile Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro 
        195                 200                 205             


His Leu Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg 
    210                 215                 220                 


Leu Met His Ala Arg Asn Thr Gly Gly Ala Ala Phe Ile Phe Pro Asn 
225                 230                 235                 240 


Thr Ser Val Tyr Pro Glu Ala Thr Gln Arg Ile Thr Thr Arg Pro Asp 
                245                 250                 255     


Leu Pro Tyr Glu Pro Pro Arg Arg Ser Ala Trp Thr Gly His Gly His 
            260                 265                 270         


Pro Thr Pro Gln Ser Lys Ala Ala Gln Pro Ser Pro Ser Thr Val Pro 
        275                 280                 285             


Lys Thr Glu Asp Gln Arg Pro Gln Leu Asp Pro Tyr Gln Ile Leu Gly 
    290                 295                 300                 


Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu 
305                 310                 315                 320 


Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ser Asn Ser Ser Cys 
                325                 330                 335     


Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp 
            340                 345                 350         


Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn 
        355                 360                 365             


Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile 
    370                 375                 380                 


Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His 
385                 390                 395                 400 


Gly Ile Ala Gln Ala Leu Gln Pro His Pro Pro Glu Ser Ser Leu Tyr 
                405                 410                 415     


Lys Tyr Pro Ser Asp Leu Pro Tyr Met Gly Ser Tyr His Ala His Pro 
            420                 425                 430         


Gln Lys Met Asn Phe Val Ala Pro His Pro Pro Ala Leu Pro Val Thr 
        435                 440                 445             


Ser Ser Ser Phe Phe Ala Ala Pro Asn Pro Tyr Trp Asn Ser Pro Thr 
    450                 455                 460                 


Gly Gly Ile Tyr Pro Asn Thr Arg Leu Pro Thr Ser His Met Pro Ser 
465                 470                 475                 480 


His Leu Gly Thr Tyr Tyr 
                485     


<210>  3645
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERGIC1__Homo_sapiens__NP_001026881

<400>  3645

Met Pro Phe Asp Phe Arg Arg Phe Asp Ile Tyr Arg Lys Val Pro Lys 
1               5                   10                  15      


Asp Leu Thr Gln Pro Thr Tyr Thr Gly Ala Ile Ile Ser Ile Cys Cys 
            20                  25                  30          


Cys Leu Phe Ile Leu Phe Leu Phe Leu Ser Glu Leu Thr Gly Phe Ile 
        35                  40                  45              


Thr Thr Glu Val Val Asn Glu Leu Tyr Val Asp Asp Pro Asp Lys Asp 
    50                  55                  60                  


Ser Gly Gly Lys Ile Asp Val Ser Leu Asn Ile Ser Leu Pro Asn Leu 
65                  70                  75                  80  


His Cys Glu Leu Val Gly Leu Asp Ile Gln Asp Glu Met Gly Arg His 
                85                  90                  95      


Glu Val Gly His Ile Asp Asn Ser Met Lys Ile Pro Leu Asn Asn Gly 
            100                 105                 110         


Ala Gly Cys Arg Phe Glu Gly Gln Phe Ser Ile Asn Lys Val Pro Gly 
        115                 120                 125             


Asn Phe His Val Ser Thr His Ser Ala Thr Ala Gln Pro Gln Asn Pro 
    130                 135                 140                 


Asp Met Thr His Val Ile His Lys Leu Ser Phe Gly Asp Thr Leu Gln 
145                 150                 155                 160 


Val Gln Asn Ile His Gly Ala Phe Asn Ala Leu Gly Gly Ala Asp Arg 
                165                 170                 175     


Leu Thr Ser Asn Pro Leu Ala Ser His Asp Tyr Ile Leu Lys Ile Val 
            180                 185                 190         


Pro Thr Val Tyr Glu Asp Lys Ser Gly Lys Gln Arg Tyr Ser Tyr Gln 
        195                 200                 205             


Tyr Thr Val Ala Asn Lys Glu Tyr Val Ala Tyr Ser His Thr Gly Arg 
    210                 215                 220                 


Ile Ile Pro Ala Ile Trp Phe Arg Tyr Asp Leu Ser Pro Ile Thr Val 
225                 230                 235                 240 


Lys Tyr Thr Glu Arg Arg Gln Pro Leu Tyr Arg Phe Ile Thr Thr Ile 
                245                 250                 255     


Cys Ala Ile Ile Gly Gly Thr Phe Thr Val Ala Gly Ile Leu Asp Ser 
            260                 265                 270         


Cys Ile Phe Thr Ala Ser Glu Ala Trp Lys Lys Ile Gln Leu Gly Lys 
        275                 280                 285             


Met His 
    290 


<210>  3646
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERGIC2__Homo_sapiens__NP_057654

<400>  3646

Met Arg Arg Leu Asn Arg Lys Lys Thr Leu Ser Leu Val Lys Glu Leu 
1               5                   10                  15      


Asp Ala Phe Pro Lys Val Pro Glu Ser Tyr Val Glu Thr Ser Ala Ser 
            20                  25                  30          


Gly Gly Thr Val Ser Leu Ile Ala Phe Thr Thr Met Ala Leu Leu Thr 
        35                  40                  45              


Ile Met Glu Phe Ser Val Tyr Gln Asp Thr Trp Met Lys Tyr Glu Tyr 
    50                  55                  60                  


Glu Val Asp Lys Asp Phe Ser Ser Lys Leu Arg Ile Asn Ile Asp Ile 
65                  70                  75                  80  


Thr Val Ala Met Lys Cys Gln Tyr Val Gly Ala Asp Val Leu Asp Leu 
                85                  90                  95      


Ala Glu Thr Met Val Ala Ser Ala Asp Gly Leu Val Tyr Glu Pro Thr 
            100                 105                 110         


Val Phe Asp Leu Ser Pro Gln Gln Lys Glu Trp Gln Arg Met Leu Gln 
        115                 120                 125             


Leu Ile Gln Ser Arg Leu Gln Glu Glu His Ser Leu Gln Asp Val Ile 
    130                 135                 140                 


Phe Lys Ser Ala Phe Lys Ser Thr Ser Thr Ala Leu Pro Pro Arg Glu 
145                 150                 155                 160 


Asp Asp Ser Ser Gln Ser Pro Asn Ala Cys Arg Ile His Gly His Leu 
                165                 170                 175     


Tyr Val Asn Lys Val Ala Gly Asn Phe His Ile Thr Val Gly Lys Ala 
            180                 185                 190         


Ile Pro His Pro Arg Gly His Ala His Leu Ala Ala Leu Val Asn His 
        195                 200                 205             


Glu Ser Tyr Asn Phe Ser His Arg Ile Asp His Leu Ser Phe Gly Glu 
    210                 215                 220                 


Leu Val Pro Ala Ile Ile Asn Pro Leu Asp Gly Thr Glu Lys Ile Ala 
225                 230                 235                 240 


Ile Asp His Asn Gln Met Phe Gln Tyr Phe Ile Thr Val Val Pro Thr 
                245                 250                 255     


Lys Leu His Thr Tyr Lys Ile Ser Ala Asp Thr His Gln Phe Ser Val 
            260                 265                 270         


Thr Glu Arg Glu Arg Ile Ile Asn His Ala Ala Gly Ser His Gly Val 
        275                 280                 285             


Ser Gly Ile Phe Met Lys Tyr Asp Leu Ser Ser Leu Met Val Thr Val 
    290                 295                 300                 


Thr Glu Glu His Met Pro Phe Trp Gln Phe Phe Val Arg Leu Cys Gly 
305                 310                 315                 320 


Ile Val Gly Gly Ile Phe Ser Thr Thr Gly Met Leu His Gly Ile Gly 
                325                 330                 335     


Lys Phe Ile Val Glu Ile Ile Cys Cys Arg Phe Arg Leu Gly Ser Tyr 
            340                 345                 350         


Lys Pro Val Asn Ser Val Pro Phe Glu Asp Gly His Thr Asp Asn His 
        355                 360                 365             


Leu Pro Leu Leu Glu Asn Asn Thr His 
    370                 375         


<210>  3647
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERGIC3__Homo_sapiens__NP_057050

<400>  3647

Met Glu Ala Leu Gly Lys Leu Lys Gln Phe Asp Ala Tyr Pro Lys Thr 
1               5                   10                  15      


Leu Glu Asp Phe Arg Val Lys Thr Cys Gly Gly Ala Thr Val Thr Ile 
            20                  25                  30          


Val Ser Gly Leu Leu Met Leu Leu Leu Phe Leu Ser Glu Leu Gln Tyr 
        35                  40                  45              


Tyr Leu Thr Thr Glu Val His Pro Glu Leu Tyr Val Asp Lys Ser Arg 
    50                  55                  60                  


Gly Asp Lys Leu Lys Ile Asn Ile Asp Val Leu Phe Pro His Met Pro 
65                  70                  75                  80  


Cys Ala Tyr Leu Ser Ile Asp Ala Met Asp Val Ala Gly Glu Gln Gln 
                85                  90                  95      


Leu Asp Val Glu His Asn Leu Phe Lys Gln Arg Leu Asp Lys Asp Gly 
            100                 105                 110         


Ile Pro Val Ser Ser Glu Ala Glu Arg His Glu Leu Gly Lys Val Glu 
        115                 120                 125             


Val Thr Val Phe Asp Pro Asp Ser Leu Asp Pro Asp Arg Cys Glu Ser 
    130                 135                 140                 


Cys Tyr Gly Ala Glu Ala Glu Asp Ile Lys Cys Cys Asn Thr Cys Glu 
145                 150                 155                 160 


Asp Val Arg Glu Ala Tyr Arg Arg Arg Gly Trp Ala Phe Lys Asn Pro 
                165                 170                 175     


Asp Thr Ile Glu Gln Cys Arg Arg Glu Gly Phe Ser Gln Lys Met Gln 
            180                 185                 190         


Glu Gln Lys Asn Glu Gly Cys Gln Val Tyr Gly Phe Leu Glu Val Asn 
        195                 200                 205             


Lys Val Ala Gly Asn Phe His Phe Ala Pro Gly Lys Ser Phe Gln Gln 
    210                 215                 220                 


Ser His Val His Val His Asp Leu Gln Ser Phe Gly Leu Asp Asn Ile 
225                 230                 235                 240 


Asn Met Thr His Tyr Ile Gln His Leu Ser Phe Gly Glu Asp Tyr Pro 
                245                 250                 255     


Gly Ile Val Asn Pro Leu Asp His Thr Asn Val Thr Ala Pro Gln Ala 
            260                 265                 270         


Ser Met Met Phe Gln Tyr Phe Val Lys Val Val Pro Thr Val Tyr Met 
        275                 280                 285             


Lys Val Asp Gly Glu Val Leu Arg Thr Asn Gln Phe Ser Val Thr Arg 
    290                 295                 300                 


His Glu Lys Val Ala Asn Gly Leu Leu Gly Asp Gln Gly Leu Pro Gly 
305                 310                 315                 320 


Val Phe Val Leu Tyr Glu Leu Ser Pro Met Met Val Lys Leu Thr Glu 
                325                 330                 335     


Lys His Arg Ser Phe Thr His Phe Leu Thr Gly Val Cys Ala Ile Ile 
            340                 345                 350         


Gly Gly Met Phe Thr Val Ala Gly Leu Ile Asp Ser Leu Ile Tyr His 
        355                 360                 365             


Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp Leu Gly Lys Thr Thr 
    370                 375                 380             


<210>  3648
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERI3__Homo_sapiens__NP_001288628

<400>  3648

Met Leu Ala Pro Leu Gln Thr Gly Ala Ala Arg Phe Ser Ser Tyr Leu 
1               5                   10                  15      


Leu Ser Arg Ala Arg Lys Val Leu Gly Ser His Leu Phe Ser Pro Cys 
            20                  25                  30          


Gly Val Pro Glu Phe Cys Ser Ile Ser Thr Arg Lys Leu Ala Ala His 
        35                  40                  45              


Gly Phe Gly Ala Ser Met Ala Ala Met Val Ser Phe Pro Pro Gln Arg 
    50                  55                  60                  


Tyr His Tyr Phe Leu Val Leu Asp Phe Glu Ala Thr Cys Asp Lys Pro 
65                  70                  75                  80  


Gln Ile His Pro Gln Glu Ile Ile Glu Phe Pro Ile Leu Lys Leu Asn 
                85                  90                  95      


Gly Arg Thr Met Glu Ile Glu Ser Thr Phe His Met Tyr Val Gln Pro 
            100                 105                 110         


Val Val His Pro Gln Leu Thr Pro Phe Cys Thr Glu Leu Thr Gly Ile 
        115                 120                 125             


Ile Gln Ala Met Val Asp Gly Gln Pro Ser Leu Gln Gln Val Leu Glu 
    130                 135                 140                 


Arg Val Asp Glu Trp Met Ala Lys Glu Gly Leu Leu Asp Pro Asn Val 
145                 150                 155                 160 


Lys Ser Ile Phe Val Thr Cys Gly Asp Trp Asp Leu Lys Val Met Leu 
                165                 170                 175     


Pro Gly Gln Cys Gln Tyr Leu Gly Leu Pro Val Ala Asp Tyr Phe Lys 
            180                 185                 190         


Gln Trp Ile Asn Leu Lys Lys Ala Tyr Ser Phe Ala Met Gly Cys Trp 
        195                 200                 205             


Pro Lys Asn Gly Leu Leu Asp Met Asn Lys Gly Leu Ser Leu Gln His 
    210                 215                 220                 


Ile Gly Arg Pro His Ser Gly Ile Asp Asp Cys Lys Asn Ile Ala Asn 
225                 230                 235                 240 


Ile Met Lys Thr Leu Ala Tyr Arg Gly Phe Ile Phe Lys Gln Thr Ser 
                245                 250                 255     


Lys Pro Phe 
            


<210>  3649
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERICH5__Homo_sapiens__NP_001164277

<400>  3649

Met Gly Cys Ser Ser Ser Ala Leu Asn Lys Ala Gly Asp Ser Ser Arg 
1               5                   10                  15      


Phe Pro Ser Gly Glu Thr Gly Glu Lys Val Glu Thr Asp Met Glu Asn 
            20                  25                  30          


Glu Lys Val Ser Glu Gly Ala Glu Thr Lys Glu Glu Glu Thr Gly Glu 
        35                  40                  45              


Val Val Asp Leu Ser Ala Ala Thr 
    50                  55      


<210>  3650
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERICH6B__Homo_sapiens__NP_872348

<400>  3650

Met Ser Ala Glu Asn Asn Gln Leu Ser Gly Ala Ser Pro Pro His Pro 
1               5                   10                  15      


Pro Thr Thr Pro Gln Tyr Ser Thr Gln Asn Leu Pro Ser Glu Lys Glu 
            20                  25                  30          


Asp Thr Glu Val Glu Leu Asp Glu Glu Ser Leu Gln Asp Glu Ser Pro 
        35                  40                  45              


Phe Ser Pro Glu Gly Glu Ser Leu Glu Asp Lys Glu Tyr Leu Glu Glu 
    50                  55                  60                  


Glu Glu Asp Leu Glu Glu Glu Glu Tyr Leu Gly Lys Glu Glu Tyr Leu 
65                  70                  75                  80  


Lys Glu Glu Glu Tyr Leu Gly Lys Glu Glu His Leu Glu Glu Glu Glu 
                85                  90                  95      


Tyr Leu Glu Lys Ala Gly Tyr Leu Glu Glu Glu Glu Tyr Ile Glu Glu 
            100                 105                 110         


Glu Glu Tyr Leu Gly Lys Glu Gly Tyr Leu Glu Glu Glu Glu Tyr Leu 
        115                 120                 125             


Gly Lys Glu Glu His Leu Glu Glu Glu Glu Tyr Leu Gly Lys Glu Gly 
    130                 135                 140                 


Tyr Leu Glu Lys Glu Asp Tyr Ile Glu Glu Val Asp Tyr Leu Gly Lys 
145                 150                 155                 160 


Lys Ala Tyr Leu Glu Glu Glu Glu Tyr Leu Gly Lys Lys Ser Tyr Leu 
                165                 170                 175     


Glu Glu Glu Lys Ala Leu Glu Lys Glu Glu Asn Leu Glu Glu Glu Glu 
            180                 185                 190         


Ala Leu Glu Lys Glu Glu Asn Leu Asp Gly Lys Glu Asn Leu Tyr Lys 
        195                 200                 205             


Lys Tyr Leu Lys Glu Pro Lys Ala Ser Tyr Ser Ser Gln Thr Met Leu 
    210                 215                 220                 


Leu Arg Asp Ala Arg Ser Pro Asp Ala Gly Pro Ser Gln Val Thr Thr 
225                 230                 235                 240 


Phe Leu Thr Val Pro Leu Thr Phe Ala Thr Pro Ser Pro Val Ser Glu 
                245                 250                 255     


Ser Ala Thr Glu Ser Ser Glu Leu Leu Leu Thr Leu Tyr Arg Arg Ser 
            260                 265                 270         


Gln Ala Ser Gln Thr Asp Trp Cys Tyr Asp Arg Thr Ala Val Lys Ser 
        275                 280                 285             


Leu Lys Ser Lys Ser Glu Thr Glu Gln Glu Thr Thr Thr Lys Leu Ala 
    290                 295                 300                 


Pro Glu Glu His Val Asn Thr Lys Val Gln Gln Lys Lys Glu Glu Asn 
305                 310                 315                 320 


Val Leu Glu Phe Ala Ser Lys Glu Asn Phe Trp Asp Gly Ile Thr Asp 
                325                 330                 335     


Glu Ser Ile Asp Lys Leu Glu Val Glu Asp Leu Asp Glu Asn Phe Leu 
            340                 345                 350         


Asn Ser Ser Tyr Gln Thr Val Phe Lys Thr Ile Ile Lys Glu Met Ala 
        355                 360                 365             


Ala His Asn Glu Leu Glu Glu Asp Phe Asp Ile Pro Leu Thr Lys Leu 
    370                 375                 380                 


Leu Glu Ser Glu Asn Arg Trp Lys Leu Val Ile Met Leu Lys Lys Asn 
385                 390                 395                 400 


Tyr Glu Lys Phe Lys Glu Thr Ile Leu Arg Ile Lys Arg Arg Arg Glu 
                405                 410                 415     


Ala Gln Lys Leu Thr Glu Met Thr Ser Phe Thr Phe His Leu Met Ser 
            420                 425                 430         


Lys Pro Thr Pro Glu Lys Pro Glu Thr Glu Glu Ile Gln Lys Pro Gln 
        435                 440                 445             


Arg Val Val His His Arg Lys Lys Leu Glu Arg Asp Lys Glu Trp Ile 
    450                 455                 460                 


Gln Lys Lys Thr Val Val His Gln Gly Asp Gly Lys Leu Ile Leu Tyr 
465                 470                 475                 480 


Pro Asn Lys Asn Val Tyr Gln Ile Leu Phe Pro Asp Gly Thr Gly Gln 
                485                 490                 495     


Ile His Tyr Pro Ser Gly Asn Leu Ala Met Leu Ile Leu Tyr Ala Lys 
            500                 505                 510         


Met Lys Lys Phe Thr Tyr Ile Ile Leu Glu Asp Ser Leu Glu Gly Arg 
        515                 520                 525             


Ile Arg Ala Leu Ile Asn Asn Ser Gly Asn Ala Thr Phe Tyr Asp Glu 
    530                 535                 540                 


Asn Ser Asp Ile Trp Leu Asn Leu Ser Ser Asn Leu Gly Tyr Tyr Phe 
545                 550                 555                 560 


Pro Lys Asp Lys Arg Gln Lys Ala Trp Asn Trp Trp Asn Leu Asn Ile 
                565                 570                 575     


His Val His Ala Pro Pro Val Gln Pro Ile Ser Leu Lys Ile Asn Glu 
            580                 585                 590         


Tyr Ile Gln Val Gln Ile Arg Ser Gln Asp Lys Ile Ile Phe Cys Phe 
        595                 600                 605             


Thr Tyr Glu Gln Lys Gln Ile Cys Leu Asn Leu Gly Thr Arg Tyr Lys 
    610                 615                 620                 


Phe Val Ile Pro Glu Val Leu Ser Glu Met Lys Lys Lys Thr Ile Leu 
625                 630                 635                 640 


Glu Ala Glu Pro Gly Pro Thr Ala Gln Lys Ile Arg Val Leu Leu Gly 
                645                 650                 655     


Lys Met Asn Arg Leu Leu Asn Tyr Ala Thr Thr Pro Asp Leu Glu Asn 
            660                 665                 670         


Phe Ile Glu Ala Val Ser Ile Ser Leu Met Asp Asn Lys Tyr Leu Lys 
        675                 680                 685             


Lys Met Leu Ser Lys Leu Trp Phe 
    690                 695     


<210>  3651
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERLEC1__Homo_sapiens__NP_001120869

<400>  3651

Met Glu Glu Gly Gly Gly Gly Val Arg Ser Leu Val Pro Gly Gly Pro 
1               5                   10                  15      


Val Leu Leu Val Leu Cys Gly Leu Leu Glu Ala Ser Gly Gly Gly Arg 
            20                  25                  30          


Ala Leu Pro Gln Leu Ser Asp Asp Ile Pro Phe Arg Val Asn Trp Pro 
        35                  40                  45              


Gly Thr Glu Phe Ser Leu Pro Thr Thr Gly Val Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Asn Tyr Val Ile Met Thr Thr Ala His Lys Glu Lys Tyr Lys Cys Ile 
65                  70                  75                  80  


Leu Pro Leu Val Thr Ser Gly Asp Glu Glu Glu Glu Lys Asp Tyr Lys 
                85                  90                  95      


Gly Pro Asn Pro Arg Glu Leu Leu Glu Pro Leu Phe Lys Gln Ser Ser 
            100                 105                 110         


Cys Ser Tyr Arg Ile Glu Ser Tyr Trp Thr Tyr Glu Val Cys His Gly 
        115                 120                 125             


Lys His Ile Arg Gln Tyr His Glu Glu Lys Glu Thr Gly Gln Lys Ile 
    130                 135                 140                 


Asn Ile His Glu Tyr Tyr Leu Gly Asn Met Leu Ala Lys Asn Leu Leu 
145                 150                 155                 160 


Phe Glu Lys Glu Arg Glu Ala Glu Glu Lys Glu Lys Ser Asn Glu Ile 
                165                 170                 175     


Pro Thr Lys Asn Ile Glu Gly Gln Met Thr Pro Tyr Tyr Pro Val Gly 
            180                 185                 190         


Met Gly Asn Gly Thr Pro Cys Ser Leu Lys Gln Asn Arg Pro Arg Ser 
        195                 200                 205             


Ser Thr Val Met Tyr Ile Cys His Pro Glu Ser Lys His Glu Ile Leu 
    210                 215                 220                 


Ser Val Ala Glu Val Thr Thr Cys Glu Tyr Glu Val Val Ile Leu Thr 
225                 230                 235                 240 


Pro Leu Leu Cys Ser His Pro Lys Tyr Arg Phe Arg Ala Ser Pro Val 
                245                 250                 255     


Asn Asp Ile Phe Cys Gln Ser Leu Pro Gly Ser Pro Phe Lys Pro Leu 
            260                 265                 270         


Thr Leu Arg Gln Leu Glu Gln Gln Glu Glu Ile Leu Arg Val Pro Phe 
        275                 280                 285             


Arg Arg Asn Lys Glu Glu Asp Leu Gln Ser Thr Lys Glu Glu Arg Phe 
    290                 295                 300                 


Pro Ala Ile His Lys Ser Ile Ala Ile Gly Ser Gln Pro Val Leu Thr 
305                 310                 315                 320 


Val Gly Thr Thr His Ile Ser Lys Leu Thr Asp Asp Gln Leu Ile Lys 
                325                 330                 335     


Glu Phe Leu Ser Gly Ser Tyr Cys Phe Arg Gly Gly Val Gly Trp Trp 
            340                 345                 350         


Lys Tyr Glu Phe Cys Tyr Gly Lys His Val His Gln Tyr His Glu Asp 
        355                 360                 365             


Lys Asp Ser Gly Lys Thr Ser Val Val Val Gly Thr Trp Asn Gln Glu 
    370                 375                 380                 


Glu His Ile Glu Trp Ala Lys Lys Asn Thr Ala Arg Ala Tyr His Leu 
385                 390                 395                 400 


Gln Asp Asp Gly Thr Gln Thr Val Arg Cys Lys Glu Ser Asp Ser Pro 
                405                 410                 415     


His Ala Val Thr Val Tyr Met Leu Glu Pro His Ser Cys Gln Tyr Ile 
            420                 425                 430         


Leu Gly Val Glu Ser Pro Val Ile Cys Lys Ile Leu Asp Thr Ala Asp 
        435                 440                 445             


Glu Asn Gly Leu Leu Ser Leu Pro Asn 
    450                 455         


<210>  3652
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERLIN1__Homo_sapiens__XP_005269499

<400>  3652

Met Asn Met Thr Gln Ala Arg Val Leu Val Ala Ala Val Val Gly Leu 
1               5                   10                  15      


Val Ala Val Leu Leu Tyr Ala Ser Ile His Lys Ile Glu Glu Gly His 
            20                  25                  30          


Leu Ala Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Pro Ser Gly 
        35                  40                  45              


Pro Gly Tyr His Ile Met Leu Pro Phe Ile Thr Thr Phe Arg Ser Val 
    50                  55                  60                  


Gln Thr Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr 
65                  70                  75                  80  


Ser Gly Gly Val Met Ile Tyr Ile Asp Arg Ile Glu Val Val Asn Met 
                85                  90                  95      


Leu Ala Pro Tyr Ala Val Phe Asp Ile Val Arg Asn Tyr Thr Ala Asp 
            100                 105                 110         


Tyr Asp Lys Thr Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln 
        115                 120                 125             


Phe Cys Ser Ala His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Asp 
    130                 135                 140                 


Gln Ile Asp Glu Asn Leu Lys Gln Ala Leu Gln Lys Asp Leu Asn Leu 
145                 150                 155                 160 


Met Ala Pro Gly Leu Thr Ile Gln Ala Val Arg Val Thr Lys Pro Lys 
                165                 170                 175     


Ile Pro Glu Ala Ile Arg Arg Asn Phe Glu Leu Met Glu Ala Glu Lys 
            180                 185                 190         


Thr Lys Leu Leu Ile Ala Ala Gln Lys Gln Lys Val Val Glu Lys Glu 
        195                 200                 205             


Ala Glu Thr Glu Arg Lys Lys Ala Val Ile Glu Ala Glu Lys Ile Ala 
    210                 215                 220                 


Gln Val Ala Lys Ile Arg Phe Gln Gln Lys Val Met Glu Lys Glu Thr 
225                 230                 235                 240 


Glu Lys Arg Ile Ser Glu Ile Glu Asp Ala Ala Phe Leu Ala Arg Glu 
                245                 250                 255     


Lys Ala Lys Ala Asp Ala Glu Tyr Tyr Ala Ala His Lys Tyr Ala Thr 
            260                 265                 270         


Ser Asn Lys His Lys Leu Thr Pro Glu Tyr Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Gln Ala Ile Ala Ser Asn Ser Lys Ile Tyr Phe Gly Ser Asn Ile Pro 
    290                 295                 300                 


Asn Met Phe Val Asp Ser Ser Cys Ala Leu Lys Tyr Ser Asp Ile Arg 
305                 310                 315                 320 


Thr Gly Arg Glu Ser Ser Leu Pro Ser Lys Glu Ala Leu Glu Pro Ser 
                325                 330                 335     


Gly Glu Asn Val Ile Gln Asn Lys Glu Ser Thr Gly 
            340                 345             


<210>  3653
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERLIN2__Homo_sapiens__NP_001003791

<400>  3653

Met Ala Gln Leu Gly Ala Val Val Ala Val Ala Ser Ser Phe Phe Cys 
1               5                   10                  15      


Ala Ser Leu Phe Ser Ala Val His Lys Ile Glu Glu Gly His Ile Gly 
            20                  25                  30          


Val Tyr Tyr Arg Gly Gly Ala Leu Leu Thr Ser Thr Ser Gly Pro Gly 
        35                  40                  45              


Phe His Leu Met Leu Pro Phe Ile Thr Ser Tyr Lys Ser Val Gln Thr 
    50                  55                  60                  


Thr Leu Gln Thr Asp Glu Val Lys Asn Val Pro Cys Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Val Met Ile Tyr Phe Asp Arg Ile Glu Val Val Asn Phe Leu Val 
                85                  90                  95      


Pro Asn Ala Val Tyr Asp Ile Val Lys Asn Tyr Thr Ala Asp Tyr Asp 
            100                 105                 110         


Lys Ala Leu Ile Phe Asn Lys Ile His His Glu Leu Asn Gln Phe Cys 
        115                 120                 125             


Ser Val His Thr Leu Gln Glu Val Tyr Ile Glu Leu Phe Gly Leu Glu 
    130                 135                 140                 


Asn Asp Phe Ser Gln Glu Ser Ser 
145                 150         


<210>  3654
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERMAP__Homo_sapiens__XP_011538872

<400>  3654

Met Glu Met Ala Ser Ser Ala Gly Ser Trp Leu Ser Gly Cys Leu Ile 
1               5                   10                  15      


Pro Leu Val Phe Leu Arg Leu Ser Val His Val Ser Gly His Ala Gly 
            20                  25                  30          


Asp Ala Gly Lys Phe His Val Ala Leu Leu Gly Gly Thr Ala Glu Leu 
        35                  40                  45              


Leu Cys Pro Leu Ser Leu Trp Pro Gly Thr Val Pro Lys Glu Val Arg 
    50                  55                  60                  


Trp Leu Arg Ser Pro Phe Pro Gln Arg Ser Gln Ala Val His Ile Phe 
65                  70                  75                  80  


Arg Asp Gly Lys Asp Gln Asp Glu Asp Leu Met Pro Glu Tyr Lys Gly 
                85                  90                  95      


Arg Thr Val Leu Val Arg Asp Ala Gln Glu Gly Ser Val Thr Leu Gln 
            100                 105                 110         


Ile Leu Asp Val Arg Leu Glu Asp Gln Gly Ser Tyr Arg Cys Leu Ile 
        115                 120                 125             


Gln Val Gly Asn Leu Ser Lys Glu Asp Thr Val Ile Leu Gln Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Gly Ser Leu Ser Pro Ser Ala Val Ala Leu Ala Val 
145                 150                 155                 160 


Ile Leu Pro Val Leu Val Leu Leu Ile Met Val Cys Leu Cys Leu Ile 
                165                 170                 175     


Trp Lys Gln Arg Arg Ala Lys Glu Lys Leu Leu Tyr Glu His Val Thr 
            180                 185                 190         


Glu Val Asp Asn Leu Leu Ser Asp His Ala Lys Glu Lys Gly Lys Leu 
        195                 200                 205             


His Lys Ala Val Lys Lys Leu Arg Ser Glu Leu Lys Leu Lys Arg Ala 
    210                 215                 220                 


Ala Ala Asn Ser Gly Trp Arg Arg Ala Arg Leu His Phe Val Ala Val 
225                 230                 235                 240 


Thr Leu Asp Pro Asp Thr Ala His Pro Lys Leu Ile Leu Ser Glu Asp 
                245                 250                 255     


Gln Arg Cys Val Arg Leu Gly Asp Arg Arg Gln Pro Val Pro Asp Asn 
            260                 265                 270         


Pro Gln Arg Phe Asp Phe Val Val Ser Ile Leu Gly Ser Glu Tyr Phe 
        275                 280                 285             


Thr Thr Gly Cys His Tyr Trp Glu Val Tyr Val Gly Asp Lys Thr Lys 
    290                 295                 300                 


Trp Ile Leu Gly Val Cys Ser Glu Ser Val Ser Arg Lys Gly Lys Val 
305                 310                 315                 320 


Thr Ala Ser Pro Ala Asn Gly His Trp Leu Leu Arg Gln Ser Arg Gly 
                325                 330                 335     


Asn Glu Tyr Glu Ala Leu Thr Ser Pro Gln Thr Ser Phe Arg Leu Lys 
            340                 345                 350         


Glu Pro Pro Arg Cys Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly Val 
        355                 360                 365             


Ile Ser Phe Tyr Asn Val Thr Asn Lys Ser His Ile Phe Thr Phe Thr 
    370                 375                 380                 


His Asn Phe Ser Gly Pro Leu Arg Pro Phe Phe Glu Pro Cys Leu His 
385                 390                 395                 400 


Asp Gly Gly Lys Asn Thr Ala Pro Leu Val Ile Cys Ser Glu Leu His 
                405                 410                 415     


Lys Ser Glu Glu Ser Ile Val Pro Arg Pro Glu Gly Lys Gly His Ala 
            420                 425                 430         


Asn Gly Asp Val Ser Leu Lys Val Asn Ser Ser Leu Leu Pro Pro Lys 
        435                 440                 445             


Ala Pro Glu Leu Lys Asp Ile Ile Leu Ser Leu Pro Pro Asp Leu Gly 
    450                 455                 460                 


Pro Ala Leu Gln Glu Leu Lys Ala Pro Ser Phe 
465                 470                 475 


<210>  3655
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERMARD__Homo_sapiens__NP_001265460

<400>  3655

Met Glu Val Leu Ile Gly Asp Pro Ile Thr Thr Cys Leu Ser Pro Ser 
1               5                   10                  15      


Val Tyr Asp Ile Ile Cys Asn Leu Gly Phe Gln Leu Arg Glu Asn Cys 
            20                  25                  30          


Asp Ile Asn Ser Ile Val Thr Gln Asn Gly Glu Val Cys Trp Lys Thr 
        35                  40                  45              


Ile Thr Asp Cys Val Ser Tyr Thr Glu Ser Glu Gln Gly Leu Asp Tyr 
    50                  55                  60                  


Trp Gly Ser Val Arg Leu Leu Gly Pro Val Cys Glu Ala Val His Ser 
65                  70                  75                  80  


His Phe Leu Ser Leu Thr Lys Gly Gln Phe Glu Ile Arg Tyr Ala Pro 
                85                  90                  95      


Trp Phe Gln Trp Thr Ser Phe Pro Glu Leu Phe Pro Glu Ile Phe Asp 
            100                 105                 110         


Ala Leu Glu Ser Leu Gln Ser Pro Ala Ile Ser Leu Ser Leu Met Lys 
        115                 120                 125             


Leu Thr Ser Cys Leu Glu Arg Ala Leu Gly Asp Val Phe Leu Leu Ile 
    130                 135                 140                 


Gly Lys Glu Cys Pro Phe Leu Leu Arg Asp Leu Leu Ser Ser Glu Glu 
145                 150                 155                 160 


Leu Ala Gln Val Phe Ser Gln Ser Val Met Asn Val Leu Lys Val Phe 
                165                 170                 175     


Val Gly Ser Pro Cys Gly Leu Asn Leu Arg Asn Val Leu Trp His Gly 
            180                 185                 190         


Phe Ala Ser Pro Glu Glu Ile Pro Pro Lys Tyr Cys Ser Met Met Ile 
        195                 200                 205             


Leu Leu Thr Ala Gly Leu Gly Gln Leu Leu Lys Ser Tyr Leu Gln Asn 
    210                 215                 220                 


Thr Lys Leu Thr Leu Ala His Arg Ser Phe Ile Ser Leu Thr Asn Leu 
225                 230                 235                 240 


Glu Asp Leu Ile Val Phe Pro Asp Val Thr Tyr Glu Val Leu Ser Val 
                245                 250                 255     


Leu Glu Glu Val Met Met Lys Ser Ala Phe Ile Leu Lys Ile Met Leu 
            260                 265                 270         


Pro Tyr Trp Glu Val Ala Leu Val Lys Phe Lys Ser His Arg Phe Ala 
        275                 280                 285             


Asp Cys Ala Ile Leu Leu Leu Thr Gln Leu Glu Thr Gly Leu Arg Asn 
    290                 295                 300                 


Val Phe Ala Thr Leu Asn Arg Cys Pro Lys Arg Leu Leu Thr Ala Glu 
305                 310                 315                 320 


Ser Thr Ala Leu Tyr Thr Thr Phe Asp Gln Ile Leu Ala Lys His Leu 
                325                 330                 335     


Asn Asp Gly Lys Ile Asn Gln Leu Pro Leu Phe Leu Gly Glu Pro Ala 
            340                 345                 350         


Met Glu Phe Leu Trp Asp Phe Leu Asn His Gln Glu Gly Pro Arg Ile 
        355                 360                 365             


Arg Asp His Leu Ser His Gly Glu Ile Asn Leu His Glu Phe Ser Lys 
    370                 375                 380                 


Glu Thr Thr Asn Gln Leu Leu Ala Phe Ser Leu Val Leu Leu Leu Arg 
385                 390                 395                 400 


Phe Val Asp Asp Cys Leu Leu Ser Val Phe Lys Glu Lys Ser Ala Val 
                405                 410                 415     


Glu Leu Leu Ile Ser Leu Ala Glu Gly Tyr Ser Ser Arg Cys His Pro 
            420                 425                 430         


Val Phe Gln Leu Lys Lys Gln Val Leu Ser Cys Glu Glu Ser Ile Arg 
        435                 440                 445             


Val Trp Ala Leu Leu Pro Phe Pro Glu Glu Leu Thr Arg Gln Ala Val 
    450                 455                 460                 


Arg Leu Glu Asp Asn Ser Glu Thr Asn Ala Cys His Ser Leu Ile Thr 
465                 470                 475                 480 


Lys Met Thr Asp Glu Leu Tyr His His Met Pro Glu Asn Arg Cys Val 
                485                 490                 495     


Leu Lys Asp Leu Asp Arg Leu Pro Thr Glu Thr Pro Thr Ser Asp Thr 
            500                 505                 510         


Pro Leu Ala Leu Ala Pro Arg Lys Pro Gln Pro Cys Arg Cys Arg Arg 
        515                 520                 525             


Arg Val Arg Pro Ser Ile Arg Leu Leu Ser Pro Val Leu Ser Leu Ile 
    530                 535                 540                 


Leu Leu Leu Ile Ala Leu Glu Leu Val Asn Ile His Ala Val Cys Gly 
545                 550                 555                 560 


Lys Asn Ala His Glu Tyr Gln Gln Tyr Leu Lys Phe Val Lys Ser Ile 
                565                 570                 575     


Leu Gln Tyr Thr Glu Asn Leu Val Ala Tyr Thr Ser Tyr Glu Lys Asn 
            580                 585                 590         


Lys Trp Asn Glu Thr Ile Asn Leu Thr His Thr Ala Leu Leu Lys Met 
        595                 600                 605             


Trp Thr Phe Ser Glu Lys Lys Gln Met Leu Ile His Leu Ala Lys Lys 
    610                 615                 620                 


Ser Thr Ser Lys Val Leu Leu 
625                 630     


<210>  3656
<211>  904
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERMP1__Homo_sapiens__NP_079172

<400>  3656

Met Glu Trp Gly Ser Glu Ser Ala Ala Val Arg Arg His Arg Val Gly 
1               5                   10                  15      


Val Glu Arg Arg Glu Gly Ala Ala Ala Ala Pro Pro Pro Glu Arg Glu 
            20                  25                  30          


Ala Arg Ala Gln Glu Pro Leu Val Asp Gly Cys Ser Gly Gly Gly Arg 
        35                  40                  45              


Thr Arg Lys Arg Ser Pro Gly Gly Ser Gly Gly Ala Ser Arg Gly Ala 
    50                  55                  60                  


Gly Thr Gly Leu Ser Glu Val Arg Ala Ala Leu Gly Leu Ala Leu Tyr 
65                  70                  75                  80  


Leu Ile Ala Leu Arg Thr Leu Val Gln Leu Ser Leu Gln Gln Leu Val 
                85                  90                  95      


Leu Arg Gly Ala Ala Gly His Arg Gly Glu Phe Asp Ala Leu Gln Ala 
            100                 105                 110         


Arg Asp Tyr Leu Glu His Ile Thr Ser Ile Gly Pro Arg Thr Thr Gly 
        115                 120                 125             


Ser Pro Glu Asn Glu Ile Leu Thr Val His Tyr Leu Leu Glu Gln Ile 
    130                 135                 140                 


Lys Leu Ile Glu Val Gln Ser Asn Ser Leu His Lys Ile Ser Val Asp 
145                 150                 155                 160 


Val Gln Arg Pro Thr Gly Ser Phe Ser Ile Asp Phe Leu Gly Gly Phe 
                165                 170                 175     


Thr Ser Tyr Tyr Asp Asn Ile Thr Asn Val Val Val Lys Leu Glu Pro 
            180                 185                 190         


Arg Asp Gly Ala Gln His Ala Val Leu Ala Asn Cys His Phe Asp Ser 
        195                 200                 205             


Val Ala Asn Ser Pro Gly Ala Ser Asp Asp Ala Val Ser Cys Ser Val 
    210                 215                 220                 


Met Leu Glu Val Leu Arg Val Leu Ser Thr Ser Ser Glu Ala Leu His 
225                 230                 235                 240 


His Ala Val Ile Phe Leu Phe Asn Gly Ala Glu Glu Asn Val Leu Gln 
                245                 250                 255     


Ala Ser His Gly Phe Ile Thr Gln His Pro Trp Ala Ser Leu Ile Arg 
            260                 265                 270         


Ala Phe Ile Asn Leu Glu Ala Ala Gly Val Gly Gly Lys Glu Leu Val 
        275                 280                 285             


Phe Gln Thr Gly Pro Glu Asn Pro Trp Leu Val Gln Ala Tyr Val Ser 
    290                 295                 300                 


Ala Ala Lys His Pro Phe Ala Ser Val Val Ala Gln Glu Val Phe Gln 
305                 310                 315                 320 


Ser Gly Ile Ile Pro Ser Asp Thr Asp Phe Arg Ile Tyr Arg Asp Phe 
                325                 330                 335     


Gly Asn Ile Pro Gly Ile Asp Leu Ala Phe Ile Glu Asn Gly Tyr Ile 
            340                 345                 350         


Tyr His Thr Lys Tyr Asp Thr Ala Asp Arg Ile Leu Thr Asp Ser Ile 
        355                 360                 365             


Gln Arg Ala Gly Asp Asn Ile Leu Ala Val Leu Lys His Leu Ala Thr 
    370                 375                 380                 


Ser Asp Met Leu Ala Ala Ala Ser Lys Tyr Arg His Gly Asn Met Val 
385                 390                 395                 400 


Phe Phe Asp Val Leu Gly Leu Phe Val Ile Ala Tyr Pro Ser Arg Ile 
                405                 410                 415     


Gly Ser Ile Ile Asn Tyr Met Val Val Met Gly Val Val Leu Tyr Leu 
            420                 425                 430         


Gly Lys Lys Phe Leu Gln Pro Lys His Lys Thr Gly Asn Tyr Lys Lys 
        435                 440                 445             


Asp Phe Leu Cys Gly Leu Gly Ile Thr Leu Ile Ser Trp Phe Thr Ser 
    450                 455                 460                 


Leu Val Thr Val Leu Ile Ile Ala Val Phe Ile Ser Leu Ile Gly Gln 
465                 470                 475                 480 


Ser Leu Ser Trp Tyr Asn His Phe Tyr Val Ser Val Cys Leu Tyr Gly 
                485                 490                 495     


Thr Ala Thr Val Ala Lys Ile Ile Leu Ile His Thr Leu Ala Lys Arg 
            500                 505                 510         


Phe Tyr Tyr Met Asn Ala Ser Ala Gln Tyr Leu Gly Glu Val Phe Phe 
        515                 520                 525             


Asp Ile Ser Leu Phe Val His Cys Cys Phe Leu Val Thr Leu Thr Tyr 
    530                 535                 540                 


Gln Gly Leu Cys Ser Ala Phe Ile Ser Ala Val Trp Val Ala Phe Pro 
545                 550                 555                 560 


Leu Leu Thr Lys Leu Cys Val His Lys Asp Phe Lys Gln His Gly Ala 
                565                 570                 575     


Gln Gly Lys Phe Ile Ala Phe Tyr Leu Leu Gly Met Phe Ile Pro Tyr 
            580                 585                 590         


Leu Tyr Ala Leu Tyr Leu Ile Trp Ala Val Phe Glu Met Phe Thr Pro 
        595                 600                 605             


Ile Leu Gly Arg Ser Gly Ser Glu Ile Pro Pro Asp Val Val Leu Ala 
    610                 615                 620                 


Ser Ile Leu Ala Gly Cys Thr Met Ile Leu Ser Ser Tyr Phe Ile Asn 
625                 630                 635                 640 


Phe Ile Tyr Leu Ala Lys Ser Thr Lys Lys Thr Met Leu Thr Leu Thr 
                645                 650                 655     


Leu Val Cys Ala Ile Thr Phe Leu Leu Val Cys Ser Gly Thr Phe Phe 
            660                 665                 670         


Pro Tyr Ser Ser Asn Pro Ala Asn Pro Lys Pro Lys Arg Val Phe Leu 
        675                 680                 685             


Gln His Met Thr Arg Thr Phe His Asp Leu Glu Gly Asn Ala Val Lys 
    690                 695                 700                 


Arg Asp Ser Gly Ile Trp Ile Asn Gly Phe Asp Tyr Thr Gly Ile Ser 
705                 710                 715                 720 


His Ile Thr Pro His Ile Pro Glu Ile Asn Asp Ser Ile Arg Ala His 
                725                 730                 735     


Cys Glu Glu Asn Ala Pro Leu Cys Gly Phe Pro Trp Tyr Leu Pro Val 
            740                 745                 750         


His Phe Leu Ile Arg Lys Asn Trp Tyr Leu Pro Ala Pro Glu Val Ser 
        755                 760                 765             


Pro Arg Asn Pro Pro His Phe Arg Leu Ile Ser Lys Glu Gln Thr Pro 
    770                 775                 780                 


Trp Asp Ser Ile Lys Leu Thr Phe Glu Ala Thr Gly Pro Ser His Met 
785                 790                 795                 800 


Ser Phe Tyr Val Arg Ala His Lys Gly Ser Thr Leu Ser Gln Trp Ser 
                805                 810                 815     


Leu Gly Asn Gly Thr Pro Val Thr Ser Lys Gly Gly Asp Tyr Phe Val 
            820                 825                 830         


Phe Tyr Ser His Gly Leu Gln Ala Ser Ala Trp Gln Phe Trp Ile Glu 
        835                 840                 845             


Val Gln Val Ser Glu Glu His Pro Glu Gly Met Val Thr Val Ala Ile 
    850                 855                 860                 


Ala Ala His Tyr Leu Ser Gly Glu Asp Lys Arg Ser Pro Gln Leu Asp 
865                 870                 875                 880 


Ala Leu Lys Glu Lys Phe Pro Asp Trp Thr Phe Pro Ser Ala Trp Val 
                885                 890                 895     


Cys Thr Tyr Asp Leu Phe Val Phe 
            900                 


<210>  3657
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERN1__Homo_sapiens__NP_001424

<400>  3657

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  3658
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERN2__Homo_sapiens__NP_150296

<400>  3658

Met Ala Ser Ala Val Arg Gly Ser Arg Pro Trp Pro Arg Leu Gly Leu 
1               5                   10                  15      


Gln Leu Gln Phe Ala Ala Leu Leu Leu Gly Thr Leu Ser Pro Gln Val 
            20                  25                  30          


His Thr Leu Arg Pro Glu Asn Leu Leu Leu Val Ser Thr Leu Asp Gly 
        35                  40                  45              


Ser Leu His Ala Leu Ser Lys Gln Thr Gly Asp Leu Lys Trp Thr Leu 
    50                  55                  60                  


Arg Asp Asp Pro Val Ile Glu Gly Pro Met Tyr Val Thr Glu Met Ala 
65                  70                  75                  80  


Phe Leu Ser Asp Pro Ala Asp Gly Ser Leu Tyr Ile Leu Gly Thr Gln 
                85                  90                  95      


Lys Gln Gln Gly Leu Met Lys Leu Pro Phe Thr Ile Pro Glu Leu Val 
            100                 105                 110         


His Ala Ser Pro Cys Arg Ser Ser Asp Gly Val Phe Tyr Thr Gly Arg 
        115                 120                 125             


Lys Gln Asp Ala Trp Phe Val Val Asp Pro Glu Ser Gly Glu Thr Gln 
    130                 135                 140                 


Met Thr Leu Thr Thr Glu Gly Pro Ser Thr Pro Arg Leu Tyr Ile Gly 
145                 150                 155                 160 


Arg Thr Gln Tyr Thr Val Thr Met His Asp Pro Arg Ala Pro Ala Leu 
                165                 170                 175     


Arg Trp Asn Thr Thr Tyr Arg Arg Tyr Ser Ala Pro Pro Met Asp Gly 
            180                 185                 190         


Ser Pro Gly Lys Tyr Met Ser His Leu Ala Ser Cys Gly Met Gly Leu 
        195                 200                 205             


Leu Leu Thr Val Asp Pro Gly Ser Gly Thr Val Leu Trp Thr Gln Asp 
    210                 215                 220                 


Leu Gly Val Pro Val Met Gly Val Tyr Thr Trp His Gln Asp Gly Leu 
225                 230                 235                 240 


Arg Gln Leu Pro His Leu Thr Leu Ala Arg Asp Thr Leu His Phe Leu 
                245                 250                 255     


Ala Leu Arg Trp Gly His Ile Arg Leu Pro Ala Ser Gly Pro Arg Asp 
            260                 265                 270         


Thr Ala Thr Leu Phe Ser Thr Leu Asp Thr Gln Leu Leu Met Thr Leu 
        275                 280                 285             


Tyr Val Gly Lys Asp Glu Thr Gly Phe Tyr Val Ser Lys Ala Leu Val 
    290                 295                 300                 


His Thr Gly Val Ala Leu Val Pro Arg Gly Leu Thr Leu Ala Pro Ala 
305                 310                 315                 320 


Asp Gly Pro Thr Thr Asp Glu Val Thr Leu Gln Val Ser Gly Glu Arg 
                325                 330                 335     


Glu Gly Ser Pro Ser Thr Ala Val Arg Tyr Pro Ser Gly Ser Val Ala 
            340                 345                 350         


Leu Pro Ser Gln Trp Leu Leu Ile Gly His His Glu Leu Pro Pro Val 
        355                 360                 365             


Leu His Thr Thr Met Leu Arg Val His Pro Thr Leu Gly Ser Gly Thr 
    370                 375                 380                 


Ala Glu Thr Arg Pro Pro Glu Asn Thr Gln Ala Pro Ala Phe Phe Leu 
385                 390                 395                 400 


Glu Leu Leu Ser Leu Ser Arg Glu Lys Leu Trp Asp Ser Glu Leu His 
                405                 410                 415     


Pro Glu Glu Lys Thr Pro Asp Ser Tyr Leu Gly Leu Gly Pro Gln Asp 
            420                 425                 430         


Leu Leu Ala Ala Ser Leu Thr Ala Val Leu Leu Gly Gly Trp Ile Leu 
        435                 440                 445             


Phe Val Met Arg Gln Gln Gln Pro Gln Val Val Glu Lys Gln Gln Glu 
    450                 455                 460                 


Thr Pro Leu Ala Pro Ala Asp Phe Ala His Ile Ser Gln Asp Ala Gln 
465                 470                 475                 480 


Ser Leu His Ser Gly Ala Ser Arg Arg Ser Gln Lys Arg Leu Gln Ser 
                485                 490                 495     


Pro Ser Lys Gln Ala Gln Pro Leu Asp Asp Pro Glu Ala Glu Gln Leu 
            500                 505                 510         


Thr Val Val Gly Lys Ile Ser Phe Asn Pro Lys Asp Val Leu Gly Arg 
        515                 520                 525             


Gly Ala Gly Gly Thr Phe Val Phe Arg Gly Gln Phe Glu Gly Arg Ala 
    530                 535                 540                 


Val Ala Val Lys Arg Leu Leu Arg Glu Cys Phe Gly Leu Val Arg Arg 
545                 550                 555                 560 


Glu Val Gln Leu Leu Gln Glu Ser Asp Arg His Pro Asn Val Leu Arg 
                565                 570                 575     


Tyr Phe Cys Thr Glu Arg Gly Pro Gln Phe His Tyr Ile Ala Leu Glu 
            580                 585                 590         


Leu Cys Arg Ala Ser Leu Gln Glu Tyr Val Glu Asn Pro Asp Leu Asp 
        595                 600                 605             


Arg Gly Gly Leu Glu Pro Glu Val Val Leu Gln Gln Leu Met Ser Gly 
    610                 615                 620                 


Leu Ala His Leu His Ser Leu His Ile Val His Arg Asp Leu Lys Pro 
625                 630                 635                 640 


Gly Asn Ile Leu Ile Thr Gly Pro Asp Ser Gln Gly Leu Gly Arg Val 
                645                 650                 655     


Val Leu Ser Asp Phe Gly Leu Cys Lys Lys Leu Pro Ala Gly Arg Cys 
            660                 665                 670         


Ser Phe Ser Leu His Ser Gly Ile Pro Gly Thr Glu Gly Trp Met Ala 
        675                 680                 685             


Pro Glu Leu Leu Gln Leu Leu Pro Pro Asp Ser Pro Thr Ser Ala Val 
    690                 695                 700                 


Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Leu Ser Gly Gly 
705                 710                 715                 720 


Ser His Pro Phe Gly Asp Ser Leu Tyr Arg Gln Ala Asn Ile Leu Thr 
                725                 730                 735     


Gly Ala Pro Cys Leu Ala His Leu Glu Glu Glu Val His Asp Lys Val 
            740                 745                 750         


Val Ala Arg Asp Leu Val Gly Ala Met Leu Ser Pro Leu Pro Gln Pro 
        755                 760                 765             


Arg Pro Ser Ala Pro Gln Val Leu Ala His Pro Phe Phe Trp Ser Arg 
    770                 775                 780                 


Ala Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Trp Leu Glu Lys 
785                 790                 795                 800 


Glu Ser Glu Gln Glu Pro Leu Val Arg Ala Leu Glu Ala Gly Gly Cys 
                805                 810                 815     


Ala Val Val Arg Asp Asn Trp His Glu His Ile Ser Met Pro Leu Gln 
            820                 825                 830         


Thr Asp Leu Arg Lys Phe Arg Ser Tyr Lys Gly Thr Ser Val Arg Asp 
        835                 840                 845             


Leu Leu Arg Ala Val Arg Asn Lys Lys His His Tyr Arg Glu Leu Pro 
    850                 855                 860                 


Val Glu Val Arg Gln Ala Leu Gly Gln Val Pro Asp Gly Phe Val Gln 
865                 870                 875                 880 


Tyr Phe Thr Asn Arg Phe Pro Arg Leu Leu Leu His Thr His Arg Ala 
                885                 890                 895     


Met Arg Ser Cys Ala Ser Glu Ser Leu Phe Leu Pro Tyr Tyr Pro Pro 
            900                 905                 910         


Asp Ser Glu Ala Arg Arg Pro Cys Pro Gly Ala Thr Gly Arg 
        915                 920                 925     


<210>  3659
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERO1LB__Homo_sapiens__NP_063944

<400>  3659

Met Ser Gln Gly Val Arg Arg Ala Gly Ala Gly Gln Gly Val Ala Ala 
1               5                   10                  15      


Ala Val Gln Leu Leu Val Thr Leu Ser Phe Leu Arg Ser Val Val Glu 
            20                  25                  30          


Ala Gln Val Thr Gly Val Leu Asp Asp Cys Leu Cys Asp Ile Asp Ser 
        35                  40                  45              


Ile Asp Asn Phe Asn Thr Tyr Lys Ile Phe Pro Lys Ile Lys Lys Leu 
    50                  55                  60                  


Gln Glu Arg Asp Tyr Phe Arg Tyr Tyr Lys Val Asn Leu Lys Arg Pro 
65                  70                  75                  80  


Cys Pro Phe Trp Ala Glu Asp Gly His Cys Ser Ile Lys Asp Cys His 
                85                  90                  95      


Val Glu Pro Cys Pro Glu Ser Lys Ile Pro Val Gly Ile Lys Ala Gly 
            100                 105                 110         


His Ser Asn Lys Tyr Leu Lys Met Ala Asn Asn Thr Lys Glu Leu Glu 
        115                 120                 125             


Asp Cys Glu Gln Ala Asn Lys Leu Gly Ala Ile Asn Ser Thr Leu Ser 
    130                 135                 140                 


Asn Gln Ser Lys Glu Ala Phe Ile Asp Trp Ala Arg Tyr Asp Asp Ser 
145                 150                 155                 160 


Arg Asp His Phe Cys Glu Leu Asp Asp Glu Arg Ser Pro Ala Ala Gln 
                165                 170                 175     


Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys Gly 
            180                 185                 190         


Thr Ser Ala Trp Arg Val Trp Asn Ser Ile Tyr Glu Glu Asn Cys Phe 
        195                 200                 205             


Lys Pro Arg Ser Val Tyr Arg Pro Leu Asn Pro Leu Ala Pro Ser Arg 
    210                 215                 220                 


Gly Glu Asp Asp Gly Glu Ser Phe Tyr Thr Trp Leu Glu Gly Leu Cys 
225                 230                 235                 240 


Leu Glu Lys Arg Val Phe Tyr Lys Leu Ile Ser Gly Leu His Ala Ser 
                245                 250                 255     


Ile Asn Leu His Leu Cys Ala Asn Tyr Leu Leu Glu Glu Thr Trp Gly 
            260                 265                 270         


Lys Pro Ser Trp Gly Pro Asn Ile Lys Glu Phe Lys His Arg Phe Asp 
        275                 280                 285             


Pro Val Glu Thr Lys Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu Tyr 
    290                 295                 300                 


Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Ala Pro Tyr 
305                 310                 315                 320 


Phe Glu Arg Ser Ile Val Asp Leu Tyr Thr Gly Asn Ala Glu Glu Asp 
                325                 330                 335     


Ala Asp Thr Lys Thr Leu Leu Leu Asn Ile Phe Gln Asp Thr Lys Ser 
            340                 345                 350         


Phe Pro Met His Phe Asp Glu Lys Ser Met Phe Ala Gly Asp Lys Lys 
        355                 360                 365             


Gly Ala Lys Ser Leu Lys Glu Glu Phe Arg Leu His Phe Lys Asn Ile 
    370                 375                 380                 


Ser Arg Ile Met Asp Cys Val Gly Cys Asp Lys Cys Arg Leu Trp Gly 
385                 390                 395                 400 


Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe Ser 
                405                 410                 415     


Glu Lys Glu Ile Gln Lys Leu Pro Glu Asn Ser Pro Ser Lys Gly Phe 
            420                 425                 430         


Gln Leu Thr Arg Gln Glu Ile Val Ala Leu Leu Asn Ala Phe Gly Arg 
        435                 440                 445             


Leu Ser Thr Ser Ile Arg Asp Leu Gln Asn Phe Lys Val Leu Leu Gln 
    450                 455                 460                 


His Ser Arg 
465         


<210>  3660
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERO1L__Homo_sapiens__NP_055399

<400>  3660

Met Gly Arg Gly Trp Gly Phe Leu Phe Gly Leu Leu Gly Ala Val Trp 
1               5                   10                  15      


Leu Leu Ser Ser Gly His Gly Glu Glu Gln Pro Pro Glu Thr Ala Ala 
            20                  25                  30          


Gln Arg Cys Phe Cys Gln Val Ser Gly Tyr Leu Asp Asp Cys Thr Cys 
        35                  40                  45              


Asp Val Glu Thr Ile Asp Arg Phe Asn Asn Tyr Arg Leu Phe Pro Arg 
    50                  55                  60                  


Leu Gln Lys Leu Leu Glu Ser Asp Tyr Phe Arg Tyr Tyr Lys Val Asn 
65                  70                  75                  80  


Leu Lys Arg Pro Cys Pro Phe Trp Asn Asp Ile Ser Gln Cys Gly Arg 
                85                  90                  95      


Arg Asp Cys Ala Val Lys Pro Cys Gln Ser Asp Glu Val Pro Asp Gly 
            100                 105                 110         


Ile Lys Ser Ala Ser Tyr Lys Tyr Ser Glu Glu Ala Asn Asn Leu Ile 
        115                 120                 125             


Glu Glu Cys Glu Gln Ala Glu Arg Leu Gly Ala Val Asp Glu Ser Leu 
    130                 135                 140                 


Ser Glu Glu Thr Gln Lys Ala Val Leu Gln Trp Thr Lys His Asp Asp 
145                 150                 155                 160 


Ser Ser Asp Asn Phe Cys Glu Ala Asp Asp Ile Gln Ser Pro Glu Ala 
                165                 170                 175     


Glu Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys 
            180                 185                 190         


Gly Pro Asp Ala Trp Lys Ile Trp Asn Val Ile Tyr Glu Glu Asn Cys 
        195                 200                 205             


Phe Lys Pro Gln Thr Ile Lys Arg Pro Leu Asn Pro Leu Ala Ser Gly 
    210                 215                 220                 


Gln Gly Thr Ser Glu Glu Asn Thr Phe Tyr Ser Trp Leu Glu Gly Leu 
225                 230                 235                 240 


Cys Val Glu Lys Arg Ala Phe Tyr Arg Leu Ile Ser Gly Leu His Ala 
                245                 250                 255     


Ser Ile Asn Val His Leu Ser Ala Arg Tyr Leu Leu Gln Glu Thr Trp 
            260                 265                 270         


Leu Glu Lys Lys Trp Gly His Asn Ile Thr Glu Phe Gln Gln Arg Phe 
        275                 280                 285             


Asp Gly Ile Leu Thr Glu Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu 
    290                 295                 300                 


Tyr Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Leu Pro 
305                 310                 315                 320 


Phe Phe Glu Arg Pro Asp Phe Gln Leu Phe Thr Gly Asn Lys Ile Gln 
                325                 330                 335     


Asp Glu Glu Asn Lys Met Leu Leu Leu Glu Ile Leu His Glu Ile Lys 
            340                 345                 350         


Ser Phe Pro Leu His Phe Asp Glu Asn Ser Phe Phe Ala Gly Asp Lys 
        355                 360                 365             


Lys Glu Ala His Lys Leu Lys Glu Asp Phe Arg Leu His Phe Arg Asn 
    370                 375                 380                 


Ile Ser Arg Ile Met Asp Cys Val Gly Cys Phe Lys Cys Arg Leu Trp 
385                 390                 395                 400 


Gly Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe 
                405                 410                 415     


Ser Glu Lys Leu Ile Ala Asn Met Pro Glu Ser Gly Pro Ser Tyr Glu 
            420                 425                 430         


Phe His Leu Thr Arg Gln Glu Ile Val Ser Leu Phe Asn Ala Phe Gly 
        435                 440                 445             


Arg Ile Ser Thr Ser Val Lys Glu Leu Glu Asn Phe Arg Asn Leu Leu 
    450                 455                 460                 


Gln Asn Ile His 
465             


<210>  3661
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERP29__Homo_sapiens__NP_001029197

<400>  3661

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
            20                  25                  30          


Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
        35                  40                  45              


Ile Met Val Thr Ser 
    50              


<210>  3662
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERP44__Homo_sapiens__NP_055866

<400>  3662

Met His Pro Ala Val Phe Leu Ser Leu Pro Asp Leu Arg Cys Ser Leu 
1               5                   10                  15      


Leu Leu Leu Val Thr Trp Val Phe Thr Pro Val Thr Thr Glu Ile Thr 
            20                  25                  30          


Ser Leu Asp Thr Glu Asn Ile Asp Glu Ile Leu Asn Asn Ala Asp Val 
        35                  40                  45              


Ala Leu Val Asn Phe Tyr Ala Asp Trp Cys Arg Phe Ser Gln Met Leu 
    50                  55                  60                  


His Pro Ile Phe Glu Glu Ala Ser Asp Val Ile Lys Glu Glu Phe Pro 
65                  70                  75                  80  


Asn Glu Asn Gln Val Val Phe Ala Arg Val Asp Cys Asp Gln His Ser 
                85                  90                  95      


Asp Ile Ala Gln Arg Tyr Arg Ile Ser Lys Tyr Pro Thr Leu Lys Leu 
            100                 105                 110         


Phe Arg Asn Gly Met Met Met Lys Arg Glu Tyr Arg Gly Gln Arg Ser 
        115                 120                 125             


Val Lys Ala Leu Ala Asp Tyr Ile Arg Gln Gln Lys Ser Asp Pro Ile 
    130                 135                 140                 


Gln Glu Ile Arg Asp Leu Ala Glu Ile Thr Thr Leu Asp Arg Ser Lys 
145                 150                 155                 160 


Arg Asn Ile Ile Gly Tyr Phe Glu Gln Lys Asp Ser Asp Asn Tyr Arg 
                165                 170                 175     


Val Phe Glu Arg Val Ala Asn Ile Leu His Asp Asp Cys Ala Phe Leu 
            180                 185                 190         


Ser Ala Phe Gly Asp Val Ser Lys Pro Glu Arg Tyr Ser Gly Asp Asn 
        195                 200                 205             


Ile Ile Tyr Lys Pro Pro Gly His Ser Ala Pro Asp Met Val Tyr Leu 
    210                 215                 220                 


Gly Ala Met Thr Asn Phe Asp Val Thr Tyr Asn Trp Ile Gln Asp Lys 
225                 230                 235                 240 


Cys Val Pro Leu Val Arg Glu Ile Thr Phe Glu Asn Gly Glu Glu Leu 
                245                 250                 255     


Thr Glu Glu Gly Leu Pro Phe Leu Ile Leu Phe His Met Lys Glu Asp 
            260                 265                 270         


Thr Glu Ser Leu Glu Ile Phe Gln Asn Glu Val Ala Arg Gln Leu Ile 
        275                 280                 285             


Ser Glu Lys Gly Thr Ile Asn Phe Leu His Ala Asp Cys Asp Lys Phe 
    290                 295                 300                 


Arg His Pro Leu Leu His Ile Gln Lys Thr Pro Ala Asp Cys Pro Val 
305                 310                 315                 320 


Ile Ala Ile Asp Ser Phe Arg His Met Tyr Val Phe Gly Asp Phe Lys 
                325                 330                 335     


Asp Val Leu Ile Pro Gly Lys Leu Lys Gln Phe Val Phe Asp Leu His 
            340                 345                 350         


Ser Gly Lys Leu His Arg Glu Phe His His Gly Pro Asp Pro Thr Asp 
        355                 360                 365             


Thr Ala Pro Gly Glu Gln Ala Gln Asp Val Ala Ser Ser Pro Pro Glu 
    370                 375                 380                 


Ser Ser Phe Gln Lys Leu Ala Pro Ser Glu Tyr Arg Tyr Thr Leu Leu 
385                 390                 395                 400 


Arg Asp Arg Asp Glu Leu 
                405     


<210>  3663
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERV3-1__Homo_sapiens__NP_001007254

<400>  3663

Met Leu Gly Met Asn Met Leu Leu Ile Thr Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Leu Ser Met Leu Lys Gly Glu Pro Trp Glu Gly Cys Leu His Cys Thr 
            20                  25                  30          


His Thr Thr Trp Ser Gly Asn Ile Met Thr Lys Thr Leu Leu Tyr His 
        35                  40                  45              


Thr Tyr Tyr Glu Cys Ala Gly Thr Cys Leu Gly Thr Cys Thr His Asn 
    50                  55                  60                  


Gln Thr Thr Tyr Ser Val Cys Asp Pro Gly Arg Gly Gln Pro Tyr Val 
65                  70                  75                  80  


Cys Tyr Asp Pro Lys Ser Ser Pro Gly Thr Trp Phe Glu Ile His Val 
                85                  90                  95      


Gly Ser Lys Glu Gly Asp Leu Leu Asn Gln Thr Lys Val Phe Pro Ser 
            100                 105                 110         


Gly Lys Asp Val Val Ser Leu Tyr Phe Asp Val Cys Gln Ile Val Ser 
        115                 120                 125             


Met Gly Ser Leu Phe Pro Val Ile Phe Ser Ser Met Glu Tyr Tyr Ser 
    130                 135                 140                 


Ser Cys His Lys Asn Arg Tyr Ala His Pro Ala Cys Ser Thr Asp Ser 
145                 150                 155                 160 


Pro Val Thr Thr Cys Trp Asp Cys Thr Thr Trp Ser Thr Asn Gln Gln 
                165                 170                 175     


Ser Leu Gly Pro Ile Met Leu Thr Lys Ile Pro Leu Glu Pro Asp Cys 
            180                 185                 190         


Lys Thr Ser Thr Cys Asn Ser Val Asn Leu Thr Ile Leu Glu Pro Asp 
        195                 200                 205             


Gln Pro Ile Trp Thr Thr Gly Leu Lys Ala Pro Leu Gly Ala Arg Val 
    210                 215                 220                 


Ser Gly Glu Glu Ile Gly Pro Gly Ala Tyr Val Tyr Leu Tyr Ile Ile 
225                 230                 235                 240 


Lys Lys Thr Arg Thr Arg Ser Thr Gln Gln Phe Arg Val Phe Glu Ser 
                245                 250                 255     


Phe Tyr Glu His Val Asn Gln Lys Leu Pro Glu Pro Pro Pro Leu Ala 
            260                 265                 270         


Ser Asn Leu Phe Ala Gln Leu Ala Glu Asn Ile Ala Ser Ser Leu His 
        275                 280                 285             


Val Ala Ser Cys Tyr Val Cys Gly Gly Met Asn Met Gly Asp Gln Trp 
    290                 295                 300                 


Pro Trp Glu Ala Arg Glu Leu Met Pro Gln Asp Asn Phe Thr Leu Thr 
305                 310                 315                 320 


Ala Ser Ser Leu Glu Pro Ala Pro Ser Ser Gln Ser Ile Trp Phe Leu 
                325                 330                 335     


Lys Thr Ser Ile Ile Gly Lys Phe Cys Ile Ala Arg Trp Gly Lys Ala 
            340                 345                 350         


Phe Thr Asp Pro Val Gly Glu Leu Thr Cys Leu Gly Gln Gln Tyr Tyr 
        355                 360                 365             


Asn Glu Thr Leu Gly Lys Thr Leu Trp Arg Gly Lys Ser Asn Asn Ser 
    370                 375                 380                 


Glu Ser Pro His Pro Ser Pro Phe Ser Arg Phe Pro Ser Leu Asn His 
385                 390                 395                 400 


Ser Trp Tyr Gln Leu Glu Ala Pro Asn Thr Trp Gln Ala Pro Ser Gly 
                405                 410                 415     


Leu Tyr Trp Ile Cys Gly Pro Gln Ala Tyr Arg Gln Leu Pro Ala Lys 
            420                 425                 430         


Trp Ser Gly Ala Cys Val Leu Gly Thr Ile Arg Pro Ser Phe Phe Leu 
        435                 440                 445             


Met Pro Leu Lys Gln Gly Glu Ala Leu Gly Tyr Pro Ile Tyr Asp Glu 
    450                 455                 460                 


Thr Lys Arg Lys Ser Lys Arg Gly Ile Thr Ile Gly Asp Trp Lys Asp 
465                 470                 475                 480 


Asn Glu Trp Pro Pro Glu Arg Ile Ile Gln Tyr Tyr Gly Pro Ala Thr 
                485                 490                 495     


Trp Ala Glu Asp Gly Met Trp Gly Tyr Arg Thr Pro Val Tyr Met Leu 
            500                 505                 510         


Asn Arg Ile Ile Arg Leu Gln Ala Val Leu Glu Ile Ile Thr Asn Glu 
        515                 520                 525             


Thr Ala Gly Ala Leu Asn Leu Leu Ala Gln Gln Ala Thr Lys Met Arg 
    530                 535                 540                 


Asn Val Ile Tyr Gln Asn Arg Leu Ala Leu Asp Tyr Leu Leu Ala Gln 
545                 550                 555                 560 


Glu Glu Gly Val Cys Gly Lys Phe Asn Leu Thr Asn Cys Cys Leu Glu 
                565                 570                 575     


Leu Asp Asp Glu Gly Lys Val Ile Lys Glu Ile Thr Ala Lys Ile Gln 
            580                 585                 590         


Lys Leu Ala His Ile Pro Val Gln Thr Trp Lys Gly 
        595                 600                 


<210>  3664
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERVW-1__Homo_sapiens__NP_055405

<400>  3664

Met Ala Leu Pro Tyr His Ile Phe Leu Phe Thr Val Leu Leu Pro Ser 
1               5                   10                  15      


Phe Thr Leu Thr Ala Pro Pro Pro Cys Arg Cys Met Thr Ser Ser Ser 
            20                  25                  30          


Pro Tyr Gln Glu Phe Leu Trp Arg Met Gln Arg Pro Gly Asn Ile Asp 
        35                  40                  45              


Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Thr Pro Thr Phe Thr Ala 
    50                  55                  60                  


His Thr His Met Pro Arg Asn Cys Tyr His Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  


His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      


Pro Gly Gly Leu Gly Val Thr Val Cys Trp Thr Tyr Phe Thr Gln Thr 
            100                 105                 110         


Gly Met Ser Asp Gly Gly Gly Val Gln Asp Gln Ala Arg Glu Lys His 
        115                 120                 125             


Val Lys Glu Val Ile Ser Gln Leu Thr Arg Val His Gly Thr Ser Ser 
    130                 135                 140                 


Pro Tyr Lys Gly Leu Asp Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 


His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Gly Leu His 
                165                 170                 175     


Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Ile Cys Leu Pro Leu 
            180                 185                 190         


Asn Phe Arg Pro Tyr Val Ser Ile Pro Val Pro Glu Gln Trp Asn Asn 
        195                 200                 205             


Phe Ser Thr Glu Ile Asn Thr Thr Ser Val Leu Val Gly Pro Leu Val 
    210                 215                 220                 


Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Cys Val Lys Phe 
225                 230                 235                 240 


Ser Asn Thr Thr Tyr Thr Thr Asn Ser Gln Cys Ile Arg Trp Val Thr 
                245                 250                 255     


Pro Pro Thr Gln Ile Val Cys Leu Pro Ser Gly Ile Phe Phe Val Cys 
            260                 265                 270         


Gly Thr Ser Ala Tyr Arg Cys Leu Asn Gly Ser Ser Glu Ser Met Cys 
        275                 280                 285             


Phe Leu Ser Phe Leu Val Pro Pro Met Thr Ile Tyr Thr Glu Gln Asp 
    290                 295                 300                 


Leu Tyr Ser Tyr Val Ile Ser Lys Pro Arg Asn Lys Arg Val Pro Ile 
305                 310                 315                 320 


Leu Pro Phe Val Ile Gly Ala Gly Val Leu Gly Ala Leu Gly Thr Gly 
                325                 330                 335     


Ile Gly Gly Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu Ser Gln 
            340                 345                 350         


Glu Leu Asn Gly Asp Met Glu Arg Val Ala Asp Ser Leu Val Thr Leu 
        355                 360                 365             


Gln Asp Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn Arg Arg 
    370                 375                 380                 


Ala Leu Asp Leu Leu Thr Ala Glu Arg Gly Gly Thr Cys Leu Phe Leu 
385                 390                 395                 400 


Gly Glu Glu Cys Cys Tyr Tyr Val Asn Gln Ser Gly Ile Val Thr Glu 
                405                 410                 415     


Lys Val Lys Glu Ile Arg Asp Arg Ile Gln Arg Arg Ala Glu Glu Leu 
            420                 425                 430         


Arg Asn Thr Gly Pro Trp Gly Leu Leu Ser Gln Trp Met Pro Trp Ile 
        435                 440                 445             


Leu Pro Phe Leu Gly Pro Leu Ala Ala Ile Ile Leu Leu Leu Leu Phe 
    450                 455                 460                 


Gly Pro Cys Ile Phe Asn Leu Leu Val Asn Phe Val Ser Ser Arg Ile 
465                 470                 475                 480 


Glu Ala Val Lys Leu Gln Met Glu Pro Lys Met Gln Ser Lys Thr Lys 
                485                 490                 495     


Ile Tyr Arg Arg Pro Leu Asp Arg Pro Ala Ser Pro Arg Ser Asp Val 
            500                 505                 510         


Asn Asp Ile Lys Gly Thr Pro Pro Glu Glu Ile Ser Ala Ala Gln Pro 
        515                 520                 525             


Leu Leu Arg Pro Asn Ser Ala Gly Ser Ser 
    530                 535             


<210>  3665
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESAM__Homo_sapiens__NP_620411

<400>  3665

Met Ile Ser Leu Pro Gly Pro Leu Val Thr Asn Leu Leu Arg Phe Leu 
1               5                   10                  15      


Phe Leu Gly Leu Ser Ala Leu Ala Pro Pro Ser Arg Ala Gln Leu Gln 
            20                  25                  30          


Leu His Leu Pro Ala Asn Arg Leu Gln Ala Val Glu Gly Gly Glu Val 
        35                  40                  45              


Val Leu Pro Ala Trp Tyr Thr Leu His Gly Glu Val Ser Ser Ser Gln 
    50                  55                  60                  


Pro Trp Glu Val Pro Phe Val Met Trp Phe Phe Lys Gln Lys Glu Lys 
65                  70                  75                  80  


Glu Asp Gln Val Leu Ser Tyr Ile Asn Gly Val Thr Thr Ser Lys Pro 
                85                  90                  95      


Gly Val Ser Leu Val Tyr Ser Met Pro Ser Arg Asn Leu Ser Leu Arg 
            100                 105                 110         


Leu Glu Gly Leu Gln Glu Lys Asp Ser Gly Pro Tyr Ser Cys Ser Val 
        115                 120                 125             


Asn Val Gln Asp Lys Gln Gly Lys Ser Arg Gly His Ser Ile Lys Thr 
    130                 135                 140                 


Leu Glu Leu Asn Val Leu Val Pro Pro Ala Pro Pro Ser Cys Arg Leu 
145                 150                 155                 160 


Gln Gly Val Pro His Val Gly Ala Asn Val Thr Leu Ser Cys Gln Ser 
                165                 170                 175     


Pro Arg Ser Lys Pro Ala Val Gln Tyr Gln Trp Asp Arg Gln Leu Pro 
            180                 185                 190         


Ser Phe Gln Thr Phe Phe Ala Pro Ala Leu Asp Val Ile Arg Gly Ser 
        195                 200                 205             


Leu Ser Leu Thr Asn Leu Ser Ser Ser Met Ala Gly Val Tyr Val Cys 
    210                 215                 220                 


Lys Ala His Asn Glu Val Gly Thr Ala Gln Cys Asn Val Thr Leu Glu 
225                 230                 235                 240 


Val Ser Thr Gly Pro Gly Ala Ala Val Val Ala Gly Ala Val Val Gly 
                245                 250                 255     


Thr Leu Val Gly Leu Gly Leu Leu Ala Gly Leu Val Leu Leu Tyr His 
            260                 265                 270         


Arg Arg Gly Lys Ala Leu Glu Glu Pro Ala Asn Asp Ile Lys Glu Asp 
        275                 280                 285             


Ala Ile Ala Pro Arg Thr Leu Pro Trp Pro Lys Ser Ser Asp Thr Ile 
    290                 295                 300                 


Ser Lys Asn Gly Thr Leu Ser Ser Val Thr Ser Ala Arg Ala Leu Arg 
305                 310                 315                 320 


Pro Pro His Gly Pro Pro Arg Pro Gly Ala Leu Thr Pro Thr Pro Ser 
                325                 330                 335     


Leu Ser Ser Gln Ala Leu Pro Ser Pro Arg Leu Pro Thr Thr Asp Gly 
            340                 345                 350         


Ala His Pro Gln Pro Ile Ser Pro Ile Pro Gly Gly Val Ser Ser Ser 
        355                 360                 365             


Gly Leu Ser Arg Met Gly Ala Val Pro Val Met Val Pro Ala Gln Ser 
    370                 375                 380                 


Gln Ala Gly Ser Leu Val 
385                 390 


<210>  3666
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESCO1__Homo_sapiens__NP_443143

<400>  3666

Met Met Ser Ile Gln Glu Lys Ser Lys Glu Asn Ser Ser Lys Val Thr 
1               5                   10                  15      


Lys Lys Ser Asp Asp Lys Asn Ser Glu Thr Glu Ile Gln Asp Ser Gln 
            20                  25                  30          


Lys Asn Leu Ala Lys Lys Ser Gly Pro Lys Glu Thr Ile Lys Ser Gln 
        35                  40                  45              


Ala Lys Ser Ser Ser Glu Ser Lys Ile Asn Gln Pro Glu Leu Glu Thr 
    50                  55                  60                  


Arg Met Ser Thr Arg Ser Ser Lys Ala Ala Ser Asn Asp Lys Ala Thr 
65                  70                  75                  80  


Lys Ser Ile Asn Lys Asn Thr Val Thr Val Arg Gly Tyr Ser Gln Glu 
                85                  90                  95      


Ser Thr Lys Lys Lys Leu Ser Gln Lys Lys Leu Val His Glu Asn Pro 
            100                 105                 110         


Lys Ala Asn Glu Gln Leu Asn Arg Arg Ser Gln Arg Leu Gln Gln Leu 
        115                 120                 125             


Thr Glu Val Ser Arg Arg Ser Leu Arg Ser Arg Glu Ile Gln Gly Gln 
    130                 135                 140                 


Val Gln Ala Val Lys Gln Ser Leu Pro Pro Thr Lys Lys Glu Gln Cys 
145                 150                 155                 160 


Ser Ser Thr Gln Ser Lys Ser Asn Lys Thr Ser Gln Lys His Val Lys 
                165                 170                 175     


Arg Lys Val Leu Glu Val Lys Ser Asp Ser Lys Glu Asp Glu Asn Leu 
            180                 185                 190         


Val Ile Asn Glu Val Ile Asn Ser Pro Lys Gly Lys Lys Arg Lys Val 
        195                 200                 205             


Glu His Gln Thr Ala Cys Ala Cys Ser Ser Gln Cys Thr Gln Gly Ser 
    210                 215                 220                 


Glu Lys Cys Pro Gln Lys Thr Thr Arg Arg Asp Glu Thr Lys Pro Val 
225                 230                 235                 240 


Pro Val Thr Ser Glu Val Lys Arg Ser Lys Met Ala Thr Ser Val Val 
                245                 250                 255     


Pro Lys Lys Asn Glu Met Lys Lys Ser Val His Thr Gln Val Asn Thr 
            260                 265                 270         


Asn Thr Thr Leu Pro Lys Ser Pro Gln Pro Ser Val Pro Glu Gln Ser 
        275                 280                 285             


Asp Asn Glu Leu Glu Gln Ala Gly Lys Ser Lys Arg Gly Ser Ile Leu 
    290                 295                 300                 


Gln Leu Cys Glu Glu Ile Ala Gly Glu Ile Glu Ser Asp Asn Val Glu 
305                 310                 315                 320 


Val Lys Lys Glu Ser Ser Gln Met Glu Ser Val Lys Glu Glu Lys Pro 
                325                 330                 335     


Thr Glu Ile Lys Leu Glu Glu Thr Ser Val Glu Arg Gln Ile Leu His 
            340                 345                 350         


Gln Lys Glu Thr Asn Gln Asp Val Gln Cys Asn Arg Phe Phe Pro Ser 
        355                 360                 365             


Arg Lys Thr Lys Pro Val Lys Cys Ile Leu Asn Gly Ile Asn Ser Ser 
    370                 375                 380                 


Ala Lys Lys Asn Ser Asn Trp Thr Lys Ile Lys Leu Ser Lys Phe Asn 
385                 390                 395                 400 


Ser Val Gln His Asn Lys Leu Asp Ser Gln Val Ser Pro Lys Leu Gly 
                405                 410                 415     


Leu Leu Arg Thr Ser Phe Ser Pro Pro Ala Leu Glu Met His His Pro 
            420                 425                 430         


Val Thr Gln Ser Thr Phe Leu Gly Thr Lys Leu His Asp Arg Asn Ile 
        435                 440                 445             


Thr Cys Gln Gln Glu Lys Met Lys Glu Ile Asn Ser Glu Glu Val Lys 
    450                 455                 460                 


Ile Asn Asp Ile Thr Val Glu Ile Asn Lys Thr Thr Glu Arg Ala Pro 
465                 470                 475                 480 


Glu Asn Cys His Leu Ala Asn Glu Ile Lys Pro Ser Asp Pro Pro Leu 
                485                 490                 495     


Asp Asn Gln Met Lys His Ser Phe Asp Ser Ala Ser Asn Lys Asn Phe 
            500                 505                 510         


Ser Gln Cys Leu Glu Ser Lys Leu Glu Asn Ser Pro Val Glu Asn Val 
        515                 520                 525             


Thr Ala Ala Ser Thr Leu Leu Ser Gln Ala Lys Ile Asp Thr Gly Glu 
    530                 535                 540                 


Asn Lys Phe Pro Gly Ser Ala Pro Gln Gln His Ser Ile Leu Ser Asn 
545                 550                 555                 560 


Gln Thr Ser Lys Ser Ser Asp Asn Arg Glu Thr Pro Arg Asn His Ser 
                565                 570                 575     


Leu Pro Lys Cys Asn Ser His Leu Glu Ile Thr Ile Pro Lys Asp Leu 
            580                 585                 590         


Lys Leu Lys Glu Ala Glu Lys Thr Asp Glu Lys Gln Leu Ile Ile Asp 
        595                 600                 605             


Ala Gly Gln Lys Arg Phe Gly Ala Val Ser Cys Asn Val Cys Gly Met 
    610                 615                 620                 


Leu Tyr Thr Ala Ser Asn Pro Glu Asp Glu Thr Gln His Leu Leu Phe 
625                 630                 635                 640 


His Asn Gln Phe Ile Ser Ala Val Lys Tyr Val Gly Trp Lys Lys Glu 
                645                 650                 655     


Arg Ile Leu Ala Glu Tyr Pro Asp Gly Arg Ile Ile Met Val Leu Pro 
            660                 665                 670         


Glu Asp Pro Lys Tyr Ala Leu Lys Lys Val Asp Glu Ile Arg Glu Met 
        675                 680                 685             


Val Asp Asn Asp Leu Gly Phe Gln Gln Ala Pro Leu Met Cys Tyr Ser 
    690                 695                 700                 


Arg Thr Lys Thr Leu Leu Phe Ile Ser Asn Asp Lys Lys Val Val Gly 
705                 710                 715                 720 


Cys Leu Ile Ala Glu His Ile Gln Trp Gly Tyr Arg Val Ile Glu Glu 
                725                 730                 735     


Lys Leu Pro Val Ile Arg Ser Glu Glu Glu Lys Val Arg Phe Glu Arg 
            740                 745                 750         


Gln Lys Ala Trp Cys Cys Ser Thr Leu Pro Glu Pro Ala Ile Cys Gly 
        755                 760                 765             


Ile Ser Arg Ile Trp Val Phe Ser Met Met Arg Arg Lys Lys Ile Ala 
    770                 775                 780                 


Ser Arg Met Ile Glu Cys Leu Arg Ser Asn Phe Ile Tyr Gly Ser Tyr 
785                 790                 795                 800 


Leu Ser Lys Glu Glu Ile Ala Phe Ser Asp Pro Thr Pro Asp Gly Lys 
                805                 810                 815     


Leu Phe Ala Thr Gln Tyr Cys Gly Thr Gly Gln Phe Leu Val Tyr Asn 
            820                 825                 830         


Phe Ile Asn Gly Gln Asn Ser Thr 
        835                 840 


<210>  3667
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESCO2__Homo_sapiens__XP_011542723

<400>  3667

Met Ala Ala Leu Thr Pro Arg Lys Arg Lys Gln Asp Ser Leu Lys Cys 
1               5                   10                  15      


Asp Ser Leu Leu His Phe Thr Glu Asn Leu Phe Pro Ser Pro Asn Lys 
            20                  25                  30          


Lys His Cys Phe Tyr Gln Asn Ser Asp Lys Asn Glu Glu Asn Leu His 
        35                  40                  45              


Cys Ser Gln Gln Glu His Phe Val Leu Ser Ala Leu Lys Thr Thr Glu 
    50                  55                  60                  


Ile Asn Arg Leu Pro Ser Ala Asn Gln Gly Ser Pro Phe Lys Ser Ala 
65                  70                  75                  80  


Leu Ser Thr Val Ser Phe Tyr Asn Gln Asn Lys Trp Tyr Leu Asn Pro 
                85                  90                  95      


Leu Glu Arg Lys Leu Ile Lys Glu Ser Arg Ser Thr Cys Leu Lys Thr 
            100                 105                 110         


Asn Asp Glu Asp Lys Ser Phe Pro Ile Val Thr Glu Lys Met Gln Gly 
        115                 120                 125             


Lys Pro Val Cys Ser Lys Lys Asn Asn Lys Lys Pro Gln Lys Ser Leu 
    130                 135                 140                 


Thr Ala Lys Tyr Gln Pro Lys Tyr Arg His Ile Lys Pro Val Ser Arg 
145                 150                 155                 160 


Asn Ser Arg Asn Ser Lys Gln Asn Arg Val Ile Tyr Lys Pro Ile Val 
                165                 170                 175     


Glu Lys Glu Asn Asn Cys His Ser Ala Glu Asn Asn Ser Asn Ala Pro 
            180                 185                 190         


Arg Val Leu Ser Gln Lys Ile Lys Pro Gln Val Thr Leu Gln Gly Gly 
        195                 200                 205             


Ala Ala Phe Phe Val Arg Lys Lys Ser Ser Leu Arg Lys Ser Ser Leu 
    210                 215                 220                 


Glu Asn Glu Pro Ser Leu Gly Arg Thr Gln Lys Ser Lys Ser Glu Val 
225                 230                 235                 240 


Ile Glu Asp Ser Asp Val Glu Thr Val Ser Glu Lys Lys Thr Phe Ala 
                245                 250                 255     


Thr Arg Gln Val Pro Lys Cys Leu Val Leu Glu Glu Lys Leu Lys Ile 
            260                 265                 270         


Gly Leu Leu Ser Ala Ser Ser Lys Asn Lys Glu Lys Leu Ile Lys Asp 
        275                 280                 285             


Ser Ser Asp Asp Arg Val Ser Ser Lys Glu His Lys Val Asp Lys Asn 
    290                 295                 300                 


Glu Ala Phe Ser Ser Glu Asp Ser Leu Gly Glu Asn Lys Thr Ile Ser 
305                 310                 315                 320 


Pro Lys Ser Thr Val Tyr Pro Ile Phe Ser Ala Ser Ser Val Asn Ser 
                325                 330                 335     


Lys Arg Ser Leu Gly Glu Glu Gln Phe Ser Val Gly Ser Val Asn Phe 
            340                 345                 350         


Met Lys Gln Thr Asn Ile Gln Lys Asn Thr Asn Thr Arg Asp Thr Ser 
        355                 360                 365             


Lys Lys Thr Lys Asp Gln Leu Ile Ile Asp Ala Gly Gln Lys His Phe 
    370                 375                 380                 


Gly Ala Thr Val Cys Lys Ser Cys Gly Met Ile Tyr Thr Ala Ser Asn 
385                 390                 395                 400 


Pro Glu Asp Glu Met Gln His Val Gln His His His Arg Phe Leu Glu 
                405                 410                 415     


Gly Ile Lys Tyr Val Gly Trp Lys Lys Glu Arg Val Val Ala Glu Phe 
            420                 425                 430         


Trp Asp Gly Lys Ile Val Leu Val Leu Pro His Asp Pro Ser Phe Ala 
        435                 440                 445             


Ile Lys Lys Val Glu Asp Val Gln Glu Leu Val Asp Asn Glu Leu Gly 
    450                 455                 460                 


Phe Gln Gln Val Val Pro Lys Cys Pro Asn Lys Ile Lys Thr Phe Leu 
465                 470                 475                 480 


Phe Ile Ser Asp Glu Lys Arg Val Val Gly Cys Leu Ile Ala Glu Pro 
                485                 490                 495     


Ile Lys Gln Ala Phe Arg Val Leu Ser Glu Pro Ile Gly Pro Glu Ser 
            500                 505                 510         


Pro Ser Ser Thr Glu Cys Pro Arg Ala Trp Gln Cys Ser Asp Val Pro 
        515                 520                 525             


Glu Pro Ala Val Cys Gly Ile Ser Arg Ile Trp Val Phe Arg Leu Lys 
    530                 535                 540                 


Arg Arg Lys Arg Ile Ala Arg Arg Leu Val Asp Thr Leu Arg Asn Cys 
545                 550                 555                 560 


Phe Met Phe Gly Cys Phe Leu Ser Thr Asp Glu Ile Ala Phe Ser Asp 
                565                 570                 575     


Pro Thr Pro Asp Gly Lys Leu Phe Ala Thr Lys Tyr Cys Asn Thr Pro 
            580                 585                 590         


Asn Phe Leu Val Tyr Asn Phe Asn Ser 
        595                 600     


<210>  3668
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESD__Homo_sapiens__XP_011533256

<400>  3668

Met Ala Leu Lys Gln Ile Ser Ser Asn Lys Cys Phe Gly Gly Leu Gln 
1               5                   10                  15      


Lys Val Phe Glu His Asp Ser Val Glu Leu Asn Cys Lys Met Lys Phe 
            20                  25                  30          


Ala Val Tyr Leu Pro Pro Lys Ala Glu Thr Gly Lys Cys Pro Ala Leu 
        35                  40                  45              


Tyr Trp Leu Ser Gly Leu Thr Cys Thr Glu Gln Asn Phe Ile Ser Lys 
    50                  55                  60                  


Ser Gly Tyr His Gln Ser Ala Ser Glu His Gly Leu Val Val Ile Ala 
65                  70                  75                  80  


Pro Asp Thr Ser Pro Arg Gly Cys Asn Ile Lys Gly Glu Asp Glu Ser 
                85                  90                  95      


Trp Asp Phe Gly Thr Gly Ala Gly Phe Tyr Val Asp Ala Thr Glu Asp 
            100                 105                 110         


Pro Trp Lys Thr Asn Tyr Arg Met Tyr Ser Tyr Val Thr Glu Glu Leu 
        115                 120                 125             


Pro Gln Leu Ile Asn Ala Asn Phe Pro Val Asp Pro Gln Arg Met Ser 
    130                 135                 140                 


Ile Phe Gly His Ser Met Gly Gly His Gly Ala Leu Ile Cys Ala Leu 
145                 150                 155                 160 


Lys Asn Pro Gly Lys Tyr Lys Ser Val Ser Ala Phe Ala Pro Ile Cys 
                165                 170                 175     


Asn Pro Val Leu Cys Pro Trp Gly Lys Lys Ala Phe Ser Gly Tyr Leu 
            180                 185                 190         


Gly Thr Asp Gln Ser Lys Trp Lys Ala Tyr Asp Ala Thr His Leu Val 
        195                 200                 205             


Lys Ser Tyr Pro Gly Ser Gln Leu Asp Ile Leu Ile Asp Gln Gly Lys 
    210                 215                 220                 


Asp Asp Gln Phe Leu Leu Asp Gly Gln Leu Leu Pro Asp Asn Phe Ile 
225                 230                 235                 240 


Ala Ala Cys Thr Glu Lys Lys Ile Pro Val Val Phe Arg Leu Gln Glu 
                245                 250                 255     


Gly Tyr Asp His Ser Tyr Tyr Phe Ile Ala Thr Phe Ile Thr Asp His 
            260                 265                 270         


Ile Arg His His Ala Lys Tyr Leu Asn Ala 
        275                 280         


<210>  3669
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESF1__Homo_sapiens__NP_001263309

<400>  3669

Met Ser Ser Lys Gln Glu Ile Met Ser Asp Gln Arg Phe Arg Arg Val 
1               5                   10                  15      


Ala Lys Asp Pro Arg Phe Trp Glu Met Pro Glu Lys Asp Arg Lys Val 
            20                  25                  30          


Lys Ile Asp Lys Arg Phe Arg Ala Met Phe His Asp Lys Lys Phe Lys 
        35                  40                  45              


Leu Asn Tyr Ala Val Asp Lys Arg Gly Arg Pro Ile Ser His Ser Thr 
    50                  55                  60                  


Thr Glu Asp Leu Lys Arg Phe Tyr Asp Leu Ser Asp Ser Asp Ser Asn 
65                  70                  75                  80  


Leu Ser Gly Glu Asp Ser Lys Ala Leu Ser Gln Lys Lys Ile Lys Lys 
                85                  90                  95      


Lys Lys Thr Gln Thr Lys Lys Glu Ile Asp Ser Lys Asn Leu Val Glu 
            100                 105                 110         


Lys Lys Lys Glu Thr Lys Lys Ala Asn His Lys Gly Ser Glu Asn Lys 
        115                 120                 125             


Thr Asp Leu Asp Asn Ser Ile Gly Ile Lys Lys Met Lys Thr Ser Cys 
    130                 135                 140                 


Lys Phe Lys Ile Asp Ser Asn Ile Ser Pro Lys Lys Asp Ser Lys Glu 
145                 150                 155                 160 


Phe Thr Gln Lys Asn Lys Lys Glu Lys Lys Asn Ile Val Gln His Thr 
                165                 170                 175     


Thr Asp Ser Ser Leu Glu Glu Lys Gln Arg Thr Leu Asp Ser Gly Thr 
            180                 185                 190         


Ser Glu Ile Val Lys Ser Pro Arg Ile Glu Cys Ser Lys Thr Arg Arg 
        195                 200                 205             


Glu Met Gln Ser Val Val Gln Leu Ile Met Thr Arg Asp Ser Asp Gly 
    210                 215                 220                 


Tyr Glu Asn Ser Thr Asp Gly Glu Met Cys Asp Lys Asp Ala Leu Glu 
225                 230                 235                 240 


Glu Asp Ser Glu Ser Val Ser Glu Ile Gly Ser Asp Glu Glu Ser Glu 
                245                 250                 255     


Asn Glu Ile Thr Ser Val Gly Arg Ala Ser Gly Asp Asp Asp Gly Ser 
            260                 265                 270         


Glu Asp Asp Glu Glu Glu Asp Glu Asp Glu Glu Glu Asp Glu Asp Glu 
        275                 280                 285             


Asp Ser Glu Asp Asp Asp Lys Ser Asp Ser Gly Pro Asp Leu Ala Arg 
    290                 295                 300                 


Gly Lys Gly Asn Ile Glu Thr Ser Ser Glu Asp Glu Asp Asp Thr Ala 
305                 310                 315                 320 


Asp Leu Phe Pro Glu Glu Ser Gly Phe Glu His Ala Trp Arg Glu Leu 
                325                 330                 335     


Asp Lys Asp Ala Pro Arg Ala Asp Glu Ile Thr Arg Arg Leu Ala Val 
            340                 345                 350         


Cys Asn Met Asp Trp Asp Arg Leu Lys Ala Lys Asp Leu Leu Ala Leu 
        355                 360                 365             


Phe Asn Ser Phe Lys Pro Lys Gly Gly Val Ile Phe Ser Val Lys Ile 
    370                 375                 380                 


Tyr Pro Ser Glu Phe Gly Lys Glu Arg Met Lys Glu Glu Gln Val Gln 
385                 390                 395                 400 


Gly Pro Val Glu Leu Leu Ser Ile Pro Glu Asp Ala Pro Glu Lys Asp 
                405                 410                 415     


Trp Thr Ser Arg Glu Lys Leu Arg Asp Tyr Gln Phe Lys Arg Leu Lys 
            420                 425                 430         


Tyr Tyr Tyr Ala Val Val Asp Cys Asp Ser Pro Glu Thr Ala Ser Lys 
        435                 440                 445             


Ile Tyr Glu Asp Cys Asp Gly Leu Glu Phe Glu Ser Ser Cys Ser Phe 
    450                 455                 460                 


Ile Asp Leu Arg Phe Ile Pro Asp Asp Ile Thr Phe Asp Asp Glu Pro 
465                 470                 475                 480 


Lys Asp Val Ala Ser Glu Val Asn Leu Thr Ala Tyr Lys Pro Lys Tyr 
                485                 490                 495     


Phe Thr Ser Ala Ala Met Gly Thr Ser Thr Val Glu Ile Thr Trp Asp 
            500                 505                 510         


Glu Thr Asp His Glu Arg Ile Thr Met Leu Asn Arg Lys Phe Lys Lys 
        515                 520                 525             


Glu Glu Leu Leu Asp Met Asp Phe Gln Ala Tyr Leu Ala Ser Ser Ser 
    530                 535                 540                 


Glu Asp Glu Glu Glu Ile Glu Glu Glu Leu Gln Gly Asp Asp Gly Val 
545                 550                 555                 560 


Asn Val Glu Glu Asp Gly Lys Thr Lys Lys Ser Gln Lys Asp Asp Glu 
                565                 570                 575     


Glu Gln Ile Ala Lys Tyr Arg Gln Leu Leu Gln Val Ile Gln Glu Lys 
            580                 585                 590         


Glu Lys Lys Gly Lys Glu Asn Asp Met Glu Met Glu Ile Lys Trp Val 
        595                 600                 605             


Pro Gly Leu Lys Glu Ser Ala Glu Glu Met Val Lys Asn Lys Leu Glu 
    610                 615                 620                 


Gly Lys Asp Lys Leu Thr Pro Trp Glu Gln Phe Leu Glu Lys Lys Lys 
625                 630                 635                 640 


Glu Lys Lys Arg Leu Lys Arg Lys Gln Lys Ala Leu Ala Glu Glu Ala 
                645                 650                 655     


Ser Glu Glu Glu Leu Pro Ser Asp Val Asp Leu Asn Asp Pro Tyr Phe 
            660                 665                 670         


Ala Glu Glu Val Lys Gln Ile Gly Ile Asn Lys Lys Ser Val Lys Ser 
        675                 680                 685             


Ala Lys Asp Gly Thr Ser Pro Glu Glu Glu Ile Glu Ile Glu Arg Gln 
    690                 695                 700                 


Lys Ala Glu Met Ala Leu Leu Met Met Asp Glu Asp Glu Asp Ser Lys 
705                 710                 715                 720 


Lys His Phe Asn Tyr Asn Lys Ile Val Glu His Gln Asn Leu Ser Lys 
                725                 730                 735     


Lys Lys Lys Lys Gln Leu Met Lys Lys Lys Glu Leu Ile Glu Asp Asp 
            740                 745                 750         


Phe Glu Val Asn Val Asn Asp Ala Arg Phe Gln Ala Met Tyr Thr Ser 
        755                 760                 765             


His Leu Phe Asn Leu Asp Pro Ser Asp Pro Asn Phe Lys Lys Thr Lys 
    770                 775                 780                 


Ala Met Glu Lys Ile Leu Glu Glu Lys Ala Arg Gln Arg Glu Arg Lys 
785                 790                 795                 800 


Glu Gln Glu Leu Thr Gln Ala Ile Lys Lys Lys Glu Ser Glu Ile Glu 
                805                 810                 815     


Lys Glu Ser Gln Arg Lys Ser Ile Asp Pro Ala Leu Ser Met Leu Ile 
            820                 825                 830         


Lys Ser Ile Lys Thr Lys Thr Glu Gln Phe Gln Ala Arg Lys Lys Gln 
        835                 840                 845             


Lys Val Lys 
    850     


<210>  3670
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESM1__Homo_sapiens__NP_001129076

<400>  3670

Met Lys Ser Val Leu Leu Leu Thr Thr Leu Leu Val Pro Ala His Leu 
1               5                   10                  15      


Val Ala Ala Trp Ser Asn Asn Tyr Ala Val Asp Cys Pro Gln His Cys 
            20                  25                  30          


Asp Ser Ser Glu Cys Lys Ser Ser Pro Arg Cys Lys Arg Thr Val Leu 
        35                  40                  45              


Asp Asp Cys Gly Cys Cys Arg Val Cys Ala Ala Gly Arg Gly Glu Thr 
    50                  55                  60                  


Cys Tyr Arg Thr Val Ser Gly Met Asp Gly Met Lys Cys Gly Pro Gly 
65                  70                  75                  80  


Leu Arg Cys Gln Pro Ser Asn Gly Glu Asp Pro Phe Gly Glu Glu Phe 
                85                  90                  95      


Gly Ile Cys Lys Glu His Asp Met Ala Ser Gly Asp Gly Asn Ile Val 
            100                 105                 110         


Arg Glu Glu Val Val Lys Glu Asn Ala Ala Gly Ser Pro Val Met Arg 
        115                 120                 125             


Lys Trp Leu Asn Pro Arg 
    130                 


<210>  3671
<211>  2120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESPL1__Homo_sapiens__NP_036423

<400>  3671

Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu Leu Ser Ser Gln 
1               5                   10                  15      


Lys Glu Ala Glu Glu Leu Leu Pro Ala Leu Lys Glu Phe Leu Ser Asn 
            20                  25                  30          


Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala Glu Arg Arg Gln 
        35                  40                  45              


Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln Leu Thr Ala Lys 
    50                  55                  60                  


Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu Leu Ala Glu Leu 
65                  70                  75                  80  


Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg Pro Pro Leu Tyr 
                85                  90                  95      


Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala Ala Ala Gln Gly 
            100                 105                 110         


Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu 
        115                 120                 125             


Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Ala 
    130                 135                 140                 


Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu Ala Leu Leu Glu 
145                 150                 155                 160 


Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu Ser Phe Leu Val 
                165                 170                 175     


Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro His Phe Ala Ser 
            180                 185                 190         


Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu Phe Asp Ala Ser 
        195                 200                 205             


Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu Asp Asp Leu Leu 
    210                 215                 220                 


Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg Gly Ser Ser Ser 
225                 230                 235                 240 


Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Leu Thr Leu 
                245                 250                 255     


Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His Asp Lys Ala Ile 
            260                 265                 270         


Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn Thr Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu Leu Gln Val Gly 
    290                 295                 300                 


Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile Lys Ala Ser Ala 
305                 310                 315                 320 


Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu 
                325                 330                 335     


Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Thr Lys 
            340                 345                 350         


Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly 
        355                 360                 365             


Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly 
    370                 375                 380                 


Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly 
385                 390                 395                 400 


Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln 
                405                 410                 415     


Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser 
            420                 425                 430         


Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu 
        435                 440                 445             


Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala 
    450                 455                 460                 


Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser 
465                 470                 475                 480 


Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro 
                485                 490                 495     


Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu 
            500                 505                 510         


Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile 
        515                 520                 525             


Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu 
    530                 535                 540                 


Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly 
545                 550                 555                 560 


Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp 
                565                 570                 575     


Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr 
            580                 585                 590         


Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys 
        595                 600                 605             


Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala 
    610                 615                 620                 


Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp 
625                 630                 635                 640 


Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala 
                645                 650                 655     


Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln 
            660                 665                 670         


Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr 
        675                 680                 685             


Leu Glu Ala Lys Met Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln 
    690                 695                 700                 


Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu 
705                 710                 715                 720 


Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn 
                725                 730                 735     


Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala 
            740                 745                 750         


Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys 
        755                 760                 765             


Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln 
    770                 775                 780                 


Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg 
785                 790                 795                 800 


Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser 
                805                 810                 815     


Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala 
            820                 825                 830         


Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln 
        835                 840                 845             


Thr Thr Asp Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg 
    850                 855                 860                 


Ser Gln Leu Tyr Trp Thr His Gln Lys Val Thr Lys Gly Val Ser Leu 
865                 870                 875                 880 


Leu Leu Ser Val Leu Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala 
                885                 890                 895     


Trp Tyr Leu Leu Arg Val Gln Val Leu Gln Leu Val Ala Ala Tyr Leu 
            900                 905                 910         


Ser Leu Pro Ser Asn Asn Leu Ser His Ser Leu Trp Glu Gln Leu Cys 
        915                 920                 925             


Ala Gln Gly Trp Gln Thr Pro Glu Ile Ala Leu Ile Asp Ser His Lys 
    930                 935                 940                 


Leu Leu Arg Ser Ile Ile Leu Leu Leu Met Gly Ser Asp Ile Leu Ser 
945                 950                 955                 960 


Thr Gln Lys Ala Ala Val Glu Thr Ser Phe Leu Asp Tyr Gly Glu Asn 
                965                 970                 975     


Leu Val Gln Lys Trp Gln Val Leu Ser Glu Val Leu Ser Cys Ser Glu 
            980                 985                 990         


Lys Leu Val Cys His Leu Gly Arg  Leu Gly Ser Val Ser  Glu Ala Lys 
        995                 1000                 1005             


Ala Phe  Cys Leu Glu Ala Leu  Lys Leu Thr Thr Lys  Leu Gln Ile 
    1010                 1015                 1020             


Pro Arg  Gln Cys Ala Leu Phe  Leu Val Leu Lys Gly  Glu Leu Glu 
    1025                 1030                 1035             


Leu Ala  Arg Asn Asp Ile Asp  Leu Cys Gln Ser Asp  Leu Gln Gln 
    1040                 1045                 1050             


Val Leu  Phe Leu Leu Glu Ser  Cys Thr Glu Phe Gly  Gly Val Thr 
    1055                 1060                 1065             


Gln His  Leu Asp Ser Val Lys  Lys Val His Leu Gln  Lys Gly Lys 
    1070                 1075                 1080             


Gln Gln  Ala Gln Val Pro Cys  Pro Pro Gln Leu Pro  Glu Glu Glu 
    1085                 1090                 1095             


Leu Phe  Leu Arg Gly Pro Ala  Leu Glu Leu Val Ala  Thr Val Ala 
    1100                 1105                 1110             


Lys Glu  Pro Gly Pro Ile Ala  Pro Ser Thr Asn Ser  Ser Pro Val 
    1115                 1120                 1125             


Leu Lys  Thr Lys Pro Gln Pro  Ile Pro Asn Phe Leu  Ser His Ser 
    1130                 1135                 1140             


Pro Thr  Cys Asp Cys Ser Leu  Cys Ala Ser Pro Val  Leu Thr Ala 
    1145                 1150                 1155             


Val Cys  Leu Arg Trp Val Leu  Val Thr Ala Gly Val  Arg Leu Ala 
    1160                 1165                 1170             


Met Gly  His Gln Ala Gln Gly  Leu Asp Leu Leu Gln  Val Val Leu 
    1175                 1180                 1185             


Lys Gly  Cys Pro Glu Ala Ala  Glu Arg Leu Thr Gln  Ala Leu Gln 
    1190                 1195                 1200             


Ala Ser  Leu Asn His Lys Thr  Pro Pro Ser Leu Val  Pro Ser Leu 
    1205                 1210                 1215             


Leu Asp  Glu Ile Leu Ala Gln  Ala Tyr Thr Leu Leu  Ala Leu Glu 
    1220                 1225                 1230             


Gly Leu  Asn Gln Pro Ser Asn  Glu Ser Leu Gln Lys  Val Leu Gln 
    1235                 1240                 1245             


Ser Gly  Leu Lys Phe Val Ala  Ala Arg Ile Pro His  Leu Glu Pro 
    1250                 1255                 1260             


Trp Arg  Ala Ser Leu Leu Leu  Ile Trp Ala Leu Thr  Lys Leu Gly 
    1265                 1270                 1275             


Gly Leu  Ser Cys Cys Thr Thr  Gln Leu Phe Ala Ser  Ser Trp Gly 
    1280                 1285                 1290             


Trp Gln  Pro Pro Leu Ile Lys  Ser Val Pro Gly Ser  Glu Pro Ser 
    1295                 1300                 1305             


Lys Thr  Gln Gly Gln Lys Arg  Ser Gly Arg Gly Arg  Gln Lys Leu 
    1310                 1315                 1320             


Ala Ser  Ala Pro Leu Arg Leu  Asn Asn Thr Ser Gln  Lys Gly Leu 
    1325                 1330                 1335             


Glu Gly  Arg Gly Leu Pro Cys  Thr Pro Lys Pro Pro  Asp Arg Ile 
    1340                 1345                 1350             


Arg Gln  Ala Gly Pro His Val  Pro Phe Thr Val Phe  Glu Glu Val 
    1355                 1360                 1365             


Cys Pro  Thr Glu Ser Lys Pro  Glu Val Pro Gln Ala  Pro Arg Val 
    1370                 1375                 1380             


Gln Gln  Arg Val Gln Thr Arg  Leu Lys Val Asn Phe  Ser Asp Asp 
    1385                 1390                 1395             


Ser Asp  Leu Glu Asp Pro Val  Ser Ala Glu Ala Trp  Leu Ala Glu 
    1400                 1405                 1410             


Glu Pro  Lys Arg Arg Gly Thr  Ala Ser Arg Gly Arg  Gly Arg Ala 
    1415                 1420                 1425             


Arg Lys  Gly Leu Ser Leu Lys  Thr Asp Ala Val Val  Ala Pro Gly 
    1430                 1435                 1440             


Ser Ala  Pro Gly Asn Pro Gly  Leu Asn Gly Arg Ser  Arg Arg Ala 
    1445                 1450                 1455             


Lys Lys  Val Ala Ser Arg His  Cys Glu Glu Arg Arg  Pro Gln Arg 
    1460                 1465                 1470             


Ala Ser  Asp Gln Ala Arg Pro  Gly Pro Glu Ile Met  Arg Thr Ile 
    1475                 1480                 1485             


Pro Glu  Glu Glu Leu Thr Asp  Asn Trp Arg Lys Met  Ser Phe Glu 
    1490                 1495                 1500             


Ile Leu  Arg Gly Ser Asp Gly  Glu Asp Ser Ala Ser  Gly Gly Lys 
    1505                 1510                 1515             


Thr Pro  Ala Pro Gly Pro Glu  Ala Ala Ser Gly Glu  Trp Glu Leu 
    1520                 1525                 1530             


Leu Arg  Leu Asp Ser Ser Lys  Lys Lys Leu Pro Ser  Pro Cys Pro 
    1535                 1540                 1545             


Asp Lys  Glu Ser Asp Lys Asp  Leu Gly Pro Arg Leu  Arg Leu Pro 
    1550                 1555                 1560             


Ser Ala  Pro Val Ala Thr Gly  Leu Ser Thr Leu Asp  Ser Ile Cys 
    1565                 1570                 1575             


Asp Ser  Leu Ser Val Ala Phe  Arg Gly Ile Ser His  Cys Pro Pro 
    1580                 1585                 1590             


Ser Gly  Leu Tyr Ala His Leu  Cys Arg Phe Leu Ala  Leu Cys Leu 
    1595                 1600                 1605             


Gly His  Arg Asp Pro Tyr Ala  Thr Ala Phe Leu Val  Thr Glu Ser 
    1610                 1615                 1620             


Val Ser  Ile Thr Cys Arg His  Gln Leu Leu Thr His  Leu His Arg 
    1625                 1630                 1635             


Gln Leu  Ser Lys Ala Gln Lys  His Arg Gly Ser Leu  Glu Ile Ala 
    1640                 1645                 1650             


Asp Gln  Leu Gln Gly Leu Ser  Leu Gln Glu Met Pro  Gly Asp Val 
    1655                 1660                 1665             


Pro Leu  Ala Arg Ile Gln Arg  Leu Phe Ser Phe Arg  Ala Leu Glu 
    1670                 1675                 1680             


Ser Gly  His Phe Pro Gln Pro  Glu Lys Glu Ser Phe  Gln Glu Arg 
    1685                 1690                 1695             


Leu Ala  Leu Ile Pro Ser Gly  Val Thr Val Cys Val  Leu Ala Leu 
    1700                 1705                 1710             


Ala Thr  Leu Gln Pro Gly Thr  Val Gly Asn Thr Leu  Leu Leu Thr 
    1715                 1720                 1725             


Arg Leu  Glu Lys Asp Ser Pro  Pro Val Ser Val Gln  Ile Pro Thr 
    1730                 1735                 1740             


Gly Gln  Asn Lys Leu His Leu  Arg Ser Val Leu Asn  Glu Phe Asp 
    1745                 1750                 1755             


Ala Ile  Gln Lys Ala Gln Lys  Glu Asn Ser Ser Cys  Thr Asp Lys 
    1760                 1765                 1770             


Arg Glu  Trp Trp Thr Gly Arg  Leu Ala Leu Asp His  Arg Met Glu 
    1775                 1780                 1785             


Val Leu  Ile Ala Ser Leu Glu  Lys Ser Val Leu Gly  Cys Trp Lys 
    1790                 1795                 1800             


Gly Leu  Leu Leu Pro Ser Ser  Glu Glu Pro Gly Pro  Ala Gln Glu 
    1805                 1810                 1815             


Ala Ser  Arg Leu Gln Glu Leu  Leu Gln Asp Cys Gly  Trp Lys Tyr 
    1820                 1825                 1830             


Pro Asp  Arg Thr Leu Leu Lys  Ile Met Leu Ser Gly  Ala Gly Ala 
    1835                 1840                 1845             


Leu Thr  Pro Gln Asp Ile Gln  Ala Leu Ala Tyr Gly  Leu Cys Pro 
    1850                 1855                 1860             


Thr Gln  Pro Glu Arg Ala Gln  Glu Leu Leu Asn Glu  Ala Val Gly 
    1865                 1870                 1875             


Arg Leu  Gln Gly Leu Thr Val  Pro Ser Asn Ser His  Leu Val Leu 
    1880                 1885                 1890             


Val Leu  Asp Lys Asp Leu Gln  Lys Leu Pro Trp Glu  Ser Met Pro 
    1895                 1900                 1905             


Ser Leu  Gln Ala Leu Pro Val  Thr Arg Leu Pro Ser  Phe Arg Phe 
    1910                 1915                 1920             


Leu Leu  Ser Tyr Ser Ile Ile  Lys Glu Tyr Gly Ala  Ser Pro Val 
    1925                 1930                 1935             


Leu Ser  Gln Gly Val Asp Pro  Arg Ser Thr Phe Tyr  Val Leu Asn 
    1940                 1945                 1950             


Pro His  Asn Asn Leu Ser Ser  Thr Glu Glu Gln Phe  Arg Ala Asn 
    1955                 1960                 1965             


Phe Ser  Ser Glu Ala Gly Trp  Arg Gly Val Val Gly  Glu Val Pro 
    1970                 1975                 1980             


Arg Pro  Glu Gln Val Gln Glu  Ala Leu Thr Lys His  Asp Leu Tyr 
    1985                 1990                 1995             


Ile Tyr  Ala Gly His Gly Ala  Gly Ala Arg Phe Leu  Asp Gly Gln 
    2000                 2005                 2010             


Ala Val  Leu Arg Leu Ser Cys  Arg Ala Val Ala Leu  Leu Phe Gly 
    2015                 2020                 2025             


Cys Ser  Ser Ala Ala Leu Ala  Val Arg Gly Asn Leu  Glu Gly Ala 
    2030                 2035                 2040             


Gly Ile  Val Leu Lys Tyr Ile  Met Ala Gly Cys Pro  Leu Phe Leu 
    2045                 2050                 2055             


Gly Asn  Leu Trp Asp Val Thr  Asp Arg Asp Ile Asp  Arg Tyr Thr 
    2060                 2065                 2070             


Glu Ala  Leu Leu Gln Gly Trp  Leu Gly Ala Gly Pro  Gly Ala Pro 
    2075                 2080                 2085             


Leu Leu  Tyr Tyr Val Asn Gln  Ala Arg Gln Ala Pro  Arg Leu Lys 
    2090                 2095                 2100             


Tyr Leu  Ile Gly Ala Ala Pro  Ile Ala Tyr Gly Leu  Pro Val Ser 
    2105                 2110                 2115             


Leu Arg  
    2120 


<210>  3672
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESPN__Homo_sapiens__XP_011540537

<400>  3672

Met Ala Leu Glu Gln Ala Leu Gln Ala Ala Arg Gln Gly Glu Leu Asp 
1               5                   10                  15      


Val Leu Arg Ser Leu His Ala Ala Gly Leu Leu Gly Pro Ser Leu Arg 
            20                  25                  30          


Asp Pro Leu Asp Ala Leu Pro Val His His Ala Ala Arg Ala Gly Lys 
        35                  40                  45              


Leu His Cys Leu Arg Phe Leu Val Glu Glu Ala Ala Leu Pro Ala Ala 
    50                  55                  60                  


Ala Arg Ala Arg Asn Gly Ala Thr Pro Ala His Asp Ala Ser Ala Thr 
65                  70                  75                  80  


Gly His Leu Ala Cys Leu Gln Trp Leu Leu Ser Gln Gly Gly Cys Arg 
                85                  90                  95      


Val Gln Asp Lys Asp Asn Ser Gly Ala Thr Val Leu His Leu Ala Ala 
            100                 105                 110         


Arg Phe Gly His Pro Glu Val Val Asn Trp Leu Leu His His Gly Gly 
        115                 120                 125             


Gly Asp Pro Thr Ala Ala Thr Asp Met Gly Ala Leu Pro Ile His Tyr 
    130                 135                 140                 


Ala Ala Ala Lys Gly Asp Phe Pro Ser Leu Arg Leu Leu Val Glu His 
145                 150                 155                 160 


Tyr Pro Glu Gly Val Asn Ala Gln Thr Lys Asn Gly Ala Thr Pro Leu 
                165                 170                 175     


Tyr Leu Ala Cys Gln Glu Gly His Leu Glu Val Thr Gln Tyr Leu Val 
            180                 185                 190         


Gln Glu Cys Gly Ala Asp Pro His Ala Arg Ala His Asp Gly Met Thr 
        195                 200                 205             


Pro Leu His Ala Ala Ala Gln Met Gly His Ser Pro Val Ile Val Trp 
    210                 215                 220                 


Leu Val Ser Cys Thr Asp Val Ser Leu Ser Glu Gln Asp Lys Asp Gly 
225                 230                 235                 240 


Ala Thr Ala Met His Phe Ala Ala Ser Arg Gly His Thr Lys Val Leu 
                245                 250                 255     


Ser Trp Leu Leu Leu His Gly Gly Glu Ile Ser Ala Asp Leu Trp Gly 
            260                 265                 270         


Gly Thr Pro Leu His Asp Ala Ala Glu Asn Gly Glu Leu Glu Cys Cys 
        275                 280                 285             


Gln Ile Leu Val Val Asn Gly Ala Glu Leu Asp Val Arg Asp Arg Asp 
    290                 295                 300                 


Gly Tyr Thr Ala Ala Asp Leu Ser Asp Phe Asn Gly His Ser His Cys 
305                 310                 315                 320 


Thr Arg Tyr Leu Arg Thr Val Glu Asn Leu Ser Val Glu His Arg Val 
                325                 330                 335     


Leu Ser Arg Asp Pro Ser Ala Glu Leu Glu Ala Lys Gln Pro Asp Ser 
            340                 345                 350         


Gly Met Ser Ser Pro Asn Thr Thr Val Ser Val Gln Pro Leu Asn Phe 
        355                 360                 365             


Asp Leu Ser Ser Pro Thr Ser Thr Leu Ser Asn Tyr Asp Ser Cys Ser 
    370                 375                 380                 


Ser Ser His Ser Ser Ile Lys Gly Gln His Pro Pro Cys Gly Leu Ser 
385                 390                 395                 400 


Ser Ala Arg Ala Ala Asp Ile Gln Ser Tyr Met Asp Met Leu Asn Pro 
                405                 410                 415     


Glu Leu Gly Leu Pro Arg Gly Thr Ile Gly Lys Pro Thr Pro Pro Pro 
            420                 425                 430         


Pro Pro Pro Ser Phe Pro Pro Pro Pro Pro Pro Pro Gly Thr Gln Leu 
        435                 440                 445             


Pro Pro Pro Pro Pro Gly Tyr Pro Ala Pro Lys Pro Pro Val Gly Pro 
    450                 455                 460                 


Gln Ala Ala Asp Ile Tyr Met Gln Thr Lys Asn Lys Leu Arg His Val 
465                 470                 475                 480 


Glu Thr Glu Ala Leu Lys Lys Glu Leu Ser Ser Cys Asp Gly His Asp 
                485                 490                 495     


Gly Leu Arg Arg Gln Asp Ser Ser Arg Lys Pro Arg Ala Phe Ser Lys 
            500                 505                 510         


Gln Pro Ser Thr Gly Asp Tyr Tyr Arg Gln Leu Gly Arg Cys Pro Gly 
        515                 520                 525             


Glu Thr Leu Ala Ala Arg Pro Gly Met Ala His Ser Glu Glu Ala Ala 
    530                 535                 540                 


Leu Leu Pro Gly Asn His Val Pro Asn Gly Cys Ala Ala Asp Pro Lys 
545                 550                 555                 560 


Ala Ser Arg Glu Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu 
                565                 570                 575     


Pro Glu Ala Ala Ser Ser Pro Pro Pro Ala Pro Pro Leu Pro Leu Glu 
            580                 585                 590         


Ser Ala Gly Pro Gly Cys Gly Gln Arg Arg Ser Ser Ser Ser Thr Gly 
        595                 600                 605             


Ser Thr Lys Ser Phe Asn Met Met Ser Pro Thr Gly Asp Asn Ser Glu 
    610                 615                 620                 


Leu Leu Ala Glu Ile Lys Ala Gly Lys Ser Leu Lys Pro Thr Pro Gln 
625                 630                 635                 640 


Ser Lys Gly Leu Thr Thr Val Phe Ser Gly Ile Gly Gln Pro Ala Phe 
                645                 650                 655     


Gln Pro Asp Ser Pro Leu Pro Ser Val Ser Pro Ala Leu Ser Pro Val 
            660                 665                 670         


Arg Ser Pro Thr Pro Pro Ala Ala Gly Phe Gln Pro Leu Leu Asn Gly 
        675                 680                 685             


Ser Leu Val Pro Val Pro Pro Thr Thr Pro Ala Pro Gly Val Gln Leu 
    690                 695                 700                 


Asp Val Glu Ala Leu Ile Pro Thr His Asp Glu Gln Gly Arg Pro Ile 
705                 710                 715                 720 


Pro Glu Trp Lys Arg Gln Val Met Val Arg Lys Met Gln Leu Lys Met 
                725                 730                 735     


Gln Glu Glu Glu Glu Gln Arg Arg Lys Glu Glu Glu Glu Glu Ala Arg 
            740                 745                 750         


Leu Ala Ser Met Pro Ala Trp Arg Arg Asp Leu Leu Arg Lys Lys Leu 
        755                 760                 765             


Glu Glu Glu Arg Glu Gln Lys Arg Lys Glu Glu Glu Arg Gln Lys Gln 
    770                 775                 780                 


Glu Glu Leu Arg Arg Glu Lys Glu Gln Ser Glu Lys Leu Arg Thr Leu 
785                 790                 795                 800 


Gly Tyr Asp Glu Ser Lys Leu Ala Pro Trp Gln Arg Gln Val Ile Leu 
                805                 810                 815     


Lys Lys Gly Asp Ile Ala Lys Tyr 
            820                 


<210>  3673
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESR1__Homo_sapiens__NP_001278159

<400>  3673

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly Asn Arg His Asn Asp Tyr Met Cys Pro 
    210                 215                 220                 


Ala Thr Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln 
225                 230                 235                 240 


Ala Cys Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly 
                245                 250                 255     


Ile Arg Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln 
            260                 265                 270         


Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met 
        275                 280                 285             


Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys 
    290                 295                 300                 


Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala 
305                 310                 315                 320 


Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr 
                325                 330                 335     


Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala 
            340                 345                 350         


Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly 
        355                 360                 365             


Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala 
    370                 375                 380                 


Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His 
385                 390                 395                 400 


Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln 
                405                 410                 415     


Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala 
            420                 425                 430         


Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val 
        435                 440                 445             


Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu 
    450                 455                 460                 


Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val 
465                 470                 475                 480 


Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly 
                485                 490                 495     


Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile 
            500                 505                 510         


Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr 
        515                 520                 525             


Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu 
    530                 535                 540                 


Met Leu Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala 
545                 550                 555                 560 


Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr 
                565                 570                 575     


Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly 
            580                 585                 590         


Phe Pro Ala Thr Val 
        595         


<210>  3674
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESR2__Homo_sapiens__NP_001201831

<400>  3674

Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr 
1               5                   10                  15      


Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile 
            20                  25                  30          


Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe 
        35                  40                  45              


Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn 
    50                  55                  60                  


Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp 
65                  70                  75                  80  


Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser 
                85                  90                  95      


His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser 
            100                 105                 110         


Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val 
        115                 120                 125             


Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg 
    130                 135                 140                 


Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His 
145                 150                 155                 160 


Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser 
                165                 170                 175     


Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr 
            180                 185                 190         


Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys 
        195                 200                 205             


Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys 
    210                 215                 220                 


Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His 
225                 230                 235                 240 


Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg 
                245                 250                 255     


Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu 
            260                 265                 270         


Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro 
        275                 280                 285             


Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys 
    290                 295                 300                 


Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val 
305                 310                 315                 320 


Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met 
                325                 330                 335     


Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly 
            340                 345                 350         


Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys 
        355                 360                 365             


Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr 
    370                 375                 380                 


Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val 
385                 390                 395                 400 


Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala 
                405                 410                 415     


Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala 
            420                 425                 430         


Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser 
        435                 440                 445             


Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His 
    450                 455                 460                 


Val Arg His Ala Arg Trp Gly Glu Lys Gln Phe Ile His Leu Lys Leu 
465                 470                 475                 480 


Ser 
    


<210>  3675
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESRP1__Homo_sapiens__NP_001030087

<400>  3675

Met Thr Ala Ser Pro Asp Tyr Leu Val Val Leu Phe Gly Ile Thr Ala 
1               5                   10                  15      


Gly Ala Thr Gly Ala Lys Leu Gly Ser Asp Glu Lys Glu Leu Ile Leu 
            20                  25                  30          


Leu Phe Trp Lys Val Val Asp Leu Ala Asn Lys Lys Val Gly Gln Leu 
        35                  40                  45              


His Glu Val Leu Val Arg Pro Asp Gln Leu Glu Leu Thr Glu Asp Cys 
    50                  55                  60                  


Lys Glu Glu Thr Lys Ile Asp Val Glu Ser Leu Ser Ser Ala Ser Gln 
65                  70                  75                  80  


Leu Asp Gln Ala Leu Arg Gln Phe Asn Gln Ser Val Ser Asn Glu Leu 
                85                  90                  95      


Asn Ile Gly Val Gly Thr Ser Phe Cys Leu Cys Thr Asp Gly Gln Leu 
            100                 105                 110         


His Val Arg Gln Ile Leu His Pro Glu Ala Ser Lys Lys Asn Val Leu 
        115                 120                 125             


Leu Pro Glu Cys Phe Tyr Ser Phe Phe Asp Leu Arg Lys Glu Phe Lys 
    130                 135                 140                 


Lys Cys Cys Pro Gly Ser Pro Asp Ile Asp Lys Leu Asp Val Ala Thr 
145                 150                 155                 160 


Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr 
                165                 170                 175     


Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile 
            180                 185                 190         


Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr 
        195                 200                 205             


Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn 
    210                 215                 220                 


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
225                 230                 235                 240 


Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala 
                245                 250                 255     


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg 
            260                 265                 270         


Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His 
        275                 280                 285             


His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp 
    290                 295                 300                 


Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu 
305                 310                 315                 320 


Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr 
                325                 330                 335     


Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile 
            340                 345                 350         


Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg 
        355                 360                 365             


Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln 
    370                 375                 380                 


Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu 
385                 390                 395                 400 


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe 
                405                 410                 415     


Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val 
            420                 425                 430         


Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg 
        435                 440                 445             


Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe 
    450                 455                 460                 


Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val 
465                 470                 475                 480 


Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys 
                485                 490                 495     


Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Asn 
            500                 505                 510         


Met Lys Asp Arg Tyr Val Glu Val Phe Gln Cys Ser Ala Glu Glu Met 
        515                 520                 525             


Asn Phe Val Leu Met Gly Gly Thr Leu Asn Arg Asn Gly Leu Ser Pro 
    530                 535                 540                 


Pro Pro Cys Leu Ser Pro Pro Ser Tyr Thr Phe Pro Ala Pro Ala Ala 
545                 550                 555                 560 


Val Ile Pro Thr Glu Ala Ala Ile Tyr Gln Pro Ser Val Ile Leu Asn 
                565                 570                 575     


Pro Arg Ala Leu Gln Pro Ser Thr Ala Tyr Tyr Pro Ala Gly Thr Gln 
            580                 585                 590         


Leu Phe Met Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro Pro Gly Ser Pro 
        595                 600                 605             


Asn Ser Leu Gly Tyr Phe Pro Thr Ala Ala Asn Leu Ser Gly Val Pro 
    610                 615                 620                 


Pro Gln Pro Gly Thr Val Val Arg Met Gln Gly Leu Ala Tyr Asn Thr 
625                 630                 635                 640 


Gly Val Lys Glu Ile Leu Asn Phe Phe Gln Gly Tyr Gln Tyr Ala Thr 
                645                 650                 655     


Glu Asp Gly Leu Ile His Thr Asn Asp Gln Ala Arg Thr Leu Pro Lys 
            660                 665                 670         


Glu Trp Val Cys Ile 
        675         


<210>  3676
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESRP2__Homo_sapiens__NP_079215

<400>  3676

Met Thr Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Asp Pro Ala 
1               5                   10                  15      


Ala Asp Pro Ala Ala Asp Pro Cys Pro Trp Pro Gly Ser Leu Val Val 
            20                  25                  30          


Leu Phe Gly Ala Thr Ala Gly Ala Leu Gly Arg Asp Leu Gly Ser Asp 
        35                  40                  45              


Glu Thr Asp Leu Ile Leu Leu Val Trp Gln Val Val Glu Pro Arg Ser 
    50                  55                  60                  


Arg Gln Val Gly Thr Leu His Lys Ser Leu Val Arg Ala Glu Ala Ala 
65                  70                  75                  80  


Ala Leu Ser Thr Gln Cys Arg Glu Ala Ser Gly Leu Ser Ala Asp Ser 
                85                  90                  95      


Leu Ala Arg Ala Glu Pro Leu Asp Lys Val Leu Gln Gln Phe Ser Gln 
            100                 105                 110         


Leu Val Asn Gly Asp Val Ala Leu Leu Gly Gly Gly Pro Tyr Met Leu 
        115                 120                 125             


Cys Thr Asp Gly Gln Gln Leu Leu Arg Gln Val Leu His Pro Glu Ala 
    130                 135                 140                 


Ser Arg Lys Asn Leu Val Leu Pro Asp Met Phe Phe Ser Phe Tyr Asp 
145                 150                 155                 160 


Leu Arg Arg Glu Phe His Met Gln His Pro Ser Thr Cys Pro Ala Arg 
                165                 170                 175     


Asp Leu Thr Val Ala Thr Met Ala Gln Gly Leu Gly Leu Glu Thr Asp 
            180                 185                 190         


Ala Thr Glu Asp Asp Phe Gly Val Trp Glu Val Lys Thr Met Val Ala 
        195                 200                 205             


Val Ile Leu His Leu Leu Lys Glu Pro Ser Ser Gln Leu Phe Ser Lys 
    210                 215                 220                 


Pro Glu Val Ile Lys Gln Lys Tyr Glu Thr Gly Pro Cys Ser Lys Ala 
225                 230                 235                 240 


Asp Val Val Asp Ser Glu Thr Val Val Arg Ala Arg Gly Leu Pro Trp 
                245                 250                 255     


Gln Ser Ser Asp Gln Asp Val Ala Arg Phe Phe Lys Gly Leu Asn Val 
            260                 265                 270         


Ala Arg Gly Gly Val Ala Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn 
        275                 280                 285             


Gly Glu Ala Leu Ile Arg Phe Val Asp Ser Glu Gln Arg Asp Leu Ala 
    290                 295                 300                 


Leu Gln Arg His Lys His His Met Gly Val Arg Tyr Ile Glu Val Tyr 
305                 310                 315                 320 


Lys Ala Thr Gly Glu Glu Phe Val Lys Ile Ala Gly Gly Thr Ser Leu 
                325                 330                 335     


Glu Val Ala Arg Phe Leu Ser Arg Glu Asp Gln Val Ile Leu Arg Leu 
            340                 345                 350         


Arg Gly Leu Pro Phe Ser Ala Gly Pro Thr Asp Val Leu Gly Phe Leu 
        355                 360                 365             


Gly Pro Glu Cys Pro Val Thr Gly Gly Thr Glu Gly Leu Leu Phe Val 
    370                 375                 380                 


Arg His Pro Asp Gly Arg Pro Thr Gly Asp Ala Phe Ala Leu Phe Ala 
385                 390                 395                 400 


Cys Glu Glu Leu Ala Gln Ala Ala Leu Arg Arg His Lys Gly Met Leu 
                405                 410                 415     


Gly Lys Arg Tyr Ile Glu Leu Phe Arg Ser Thr Ala Ala Glu Val Gln 
            420                 425                 430         


Gln Val Leu Asn Arg Tyr Ala Ser Gly Pro Leu Leu Pro Thr Leu Thr 
        435                 440                 445             


Ala Pro Leu Leu Pro Ile Pro Phe Pro Leu Ala Pro Gly Thr Gly Arg 
    450                 455                 460                 


Asp Cys Val Arg Leu Arg Gly Leu Pro Tyr Thr Ala Thr Ile Glu Asp 
465                 470                 475                 480 


Ile Leu Ser Phe Leu Gly Glu Ala Ala Ala Asp Ile Arg Pro His Gly 
                485                 490                 495     


Val His Met Val Leu Asn Gln Gln Gly Arg Pro Ser Gly Asp Ala Phe 
            500                 505                 510         


Ile Gln Met Thr Ser Ala Glu Arg Ala Leu Ala Ala Ala Gln Arg Cys 
        515                 520                 525             


His Lys Lys Val Met Lys Glu Arg Tyr Val Glu Val Val Pro Cys Ser 
    530                 535                 540                 


Thr Glu Glu Met Ser Arg Val Leu Met Gly Gly Thr Leu Gly Arg Ser 
545                 550                 555                 560 


Gly Met Ser Pro Pro Pro Cys Lys Leu Pro Cys Leu Ser Pro Pro Thr 
                565                 570                 575     


Tyr Thr Thr Phe Gln Ala Thr Pro Thr Leu Ile Pro Thr Glu Thr Ala 
            580                 585                 590         


Ala Leu Tyr Pro Ser Ser Ala Leu Leu Pro Ala Ala Arg Val Pro Ala 
        595                 600                 605             


Ala Pro Thr Pro Val Ala Tyr Tyr Pro Gly Pro Ala Thr Gln Leu Tyr 
    610                 615                 620                 


Leu Asn Tyr Thr Ala Tyr Tyr Pro Ser Pro Pro Val Ser Pro Thr Thr 
625                 630                 635                 640 


Val Gly Tyr Leu Thr Thr Pro Thr Ala Ala Leu Ala Ser Ala Pro Thr 
                645                 650                 655     


Ser Val Leu Ser Gln Ser Gly Ala Leu Val Arg Met Gln Gly Val Pro 
            660                 665                 670         


Tyr Thr Ala Gly Met Lys Asp Leu Leu Ser Val Phe Gln Ala Tyr Gln 
        675                 680                 685             


Leu Pro Ala Asp Asp Tyr Thr Ser Leu Met Pro Val Gly Asp Pro Pro 
    690                 695                 700                 


Arg Thr Val Leu Gln Ala Pro Lys Glu Trp Val Cys Leu 
705                 710                 715         


<210>  3677
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESRRA__Homo_sapiens__NP_001269379

<400>  3677

Met Ser Ser Gln Val Val Gly Ile Glu Pro Leu Tyr Ile Lys Ala Glu 
1               5                   10                  15      


Pro Ala Ser Pro Asp Ser Pro Lys Gly Ser Ser Glu Thr Glu Thr Glu 
            20                  25                  30          


Pro Pro Val Ala Leu Ala Pro Gly Pro Ala Pro Thr Arg Cys Leu Pro 
        35                  40                  45              


Gly His Lys Glu Glu Glu Asp Gly Glu Gly Ala Gly Pro Gly Glu Gln 
    50                  55                  60                  


Gly Gly Gly Lys Leu Val Leu Ser Ser Leu Pro Lys Arg Leu Cys Leu 
65                  70                  75                  80  


Val Cys Gly Asp Val Ala Ser Gly Tyr His Tyr Gly Val Ala Ser Cys 
                85                  90                  95      


Glu Ala Cys Lys Ala Phe Phe Lys Arg Thr Ile Gln Gly Ser Ile Glu 
            100                 105                 110         


Tyr Ser Cys Pro Ala Ser Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg 
        115                 120                 125             


Lys Ala Cys Gln Ala Cys Arg Phe Thr Lys Cys Leu Arg Val Gly Met 
    130                 135                 140                 


Leu Lys Glu Gly Val Arg Leu Asp Arg Val Arg Gly Gly Arg Gln Lys 
145                 150                 155                 160 


Tyr Lys Arg Arg Pro Glu Val Asp Pro Leu Pro Phe Pro Gly Pro Phe 
                165                 170                 175     


Pro Ala Gly Pro Leu Ala Val Ala Gly Gly Pro Arg Lys Thr Ala Ala 
            180                 185                 190         


Pro Val Asn Ala Leu Val Ser His Leu Leu Val Val Glu Pro Glu Lys 
        195                 200                 205             


Leu Tyr Ala Met Pro Asp Pro Ala Gly Pro Asp Gly His Leu Pro Ala 
    210                 215                 220                 


Val Ala Thr Leu Cys Asp Leu Phe Asp Arg Glu Ile Val Val Thr Ile 
225                 230                 235                 240 


Ser Trp Ala Lys Ser Ile Pro Gly Phe Ser Ser Leu Ser Leu Ser Asp 
                245                 250                 255     


Gln Met Ser Val Leu Gln Ser Val Trp Met Glu Val Leu Val Leu Gly 
            260                 265                 270         


Val Ala Gln Arg Ser Leu Pro Leu Gln Asp Glu Leu Ala Phe Ala Glu 
        275                 280                 285             


Asp Leu Val Leu Asp Glu Glu Gly Ala Arg Ala Ala Gly Leu Gly Glu 
    290                 295                 300                 


Leu Gly Ala Ala Leu Leu Gln Leu Val Arg Arg Leu Gln Ala Leu Arg 
305                 310                 315                 320 


Leu Glu Arg Glu Glu Tyr Val Leu Leu Lys Ala Leu Ala Leu Ala Asn 
                325                 330                 335     


Ser Asp Ser Val His Ile Glu Asp Ala Glu Ala Val Glu Gln Leu Arg 
            340                 345                 350         


Glu Ala Leu His Glu Ala Leu Leu Glu Tyr Glu Ala Gly Arg Ala Gly 
        355                 360                 365             


Pro Gly Gly Gly Ala Glu Arg Arg Arg Ala Gly Arg Leu Leu Leu Thr 
    370                 375                 380                 


Leu Pro Leu Leu Arg Gln Thr Ala Gly Lys Val Leu Ala His Phe Tyr 
385                 390                 395                 400 


Gly Val Lys Leu Glu Gly Lys Val Pro Met His Lys Leu Phe Leu Glu 
                405                 410                 415     


Met Leu Glu Ala Met Met Asp 
            420             


<210>  3678
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESRRB__Homo_sapiens__NP_004443

<400>  3678

Met Ser Ser Asp Asp Arg His Leu Gly Ser Ser Cys Gly Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ser Ser Gly Ile Asp Ala Leu Ser His 
            20                  25                  30          


His Ser Pro Ser Gly Ser Ser Asp Ala Ser Gly Gly Phe Gly Leu Ala 
        35                  40                  45              


Leu Gly Thr His Ala Asn Gly Leu Asp Ser Pro Pro Met Phe Ala Gly 
    50                  55                  60                  


Ala Gly Leu Gly Gly Thr Pro Cys Arg Lys Ser Tyr Glu Asp Cys Ala 
65                  70                  75                  80  


Ser Gly Ile Met Glu Asp Ser Ala Ile Lys Cys Glu Tyr Met Leu Asn 
                85                  90                  95      


Ala Ile Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala Ser Gly 
            100                 105                 110         


Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe Phe Lys 
        115                 120                 125             


Arg Thr Ile Gln Gly Asn Ile Glu Tyr Ser Cys Pro Ala Thr Asn Glu 
    130                 135                 140                 


Cys Glu Ile Thr Lys Arg Arg Arg Lys Ser Cys Gln Ala Cys Arg Phe 
145                 150                 155                 160 


Met Lys Cys Leu Lys Val Gly Met Leu Lys Glu Gly Val Arg Leu Asp 
                165                 170                 175     


Arg Val Arg Gly Gly Arg Gln Lys Tyr Lys Arg Arg Leu Asp Ser Glu 
            180                 185                 190         


Ser Ser Pro Tyr Leu Ser Leu Gln Ile Ser Pro Pro Ala Lys Lys Pro 
        195                 200                 205             


Leu Thr Lys Ile Val Ser Tyr Leu Leu Val Ala Glu Pro Asp Lys Leu 
    210                 215                 220                 


Tyr Ala Met Pro Pro Pro Gly Met Pro Glu Gly Asp Ile Lys Ala Leu 
225                 230                 235                 240 


Thr Thr Leu Cys Asp Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly 
                245                 250                 255     


Trp Ala Lys His Ile Pro Gly Phe Ser Ser Leu Ser Leu Gly Asp Gln 
            260                 265                 270         


Met Ser Leu Leu Gln Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Ile 
        275                 280                 285             


Val Tyr Arg Ser Leu Pro Tyr Asp Asp Lys Leu Val Tyr Ala Glu Asp 
    290                 295                 300                 


Tyr Ile Met Asp Glu Glu His Ser Arg Leu Ala Gly Leu Leu Glu Leu 
305                 310                 315                 320 


Tyr Arg Ala Ile Leu Gln Leu Val Arg Arg Tyr Lys Lys Leu Lys Val 
                325                 330                 335     


Glu Lys Glu Glu Phe Val Thr Leu Lys Ala Leu Ala Leu Ala Asn Ser 
            340                 345                 350         


Asp Ser Met Tyr Ile Glu Asp Leu Glu Ala Val Gln Lys Leu Gln Asp 
        355                 360                 365             


Leu Leu His Glu Ala Leu Gln Asp Tyr Glu Leu Ser Gln Arg His Glu 
    370                 375                 380                 


Glu Pro Trp Arg Thr Gly Lys Leu Leu Leu Thr Leu Pro Leu Leu Arg 
385                 390                 395                 400 


Gln Thr Ala Ala Lys Ala Val Gln His Phe Tyr Ser Val Lys Leu Gln 
                405                 410                 415     


Gly Lys Val Pro Met His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys 
            420                 425                 430         


Val Gly Gln Glu Gln Leu Arg Gly Ser Pro Lys Asp Glu Arg Met Ser 
        435                 440                 445             


Ser His Asp Gly Lys Cys Pro Phe Gln Ser Ala Ala Phe Thr Ser Arg 
    450                 455                 460                 


Asp Gln Ser Asn Ser Pro Gly Ile Pro Asn Pro Arg Pro Ser Ser Pro 
465                 470                 475                 480 


Thr Pro Leu Asn Glu Arg Gly Arg Gln Ile Ser Pro Ser Thr Arg Thr 
                485                 490                 495     


Pro Gly Gly Gln Gly Lys His Leu Trp Leu Thr Met 
            500                 505             


<210>  3679
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESRRG__Homo_sapiens__NP_001230436

<400>  3679

Met Ser Asn Lys Asp Arg His Ile Asp Ser Ser Cys Ser Ser Phe Ile 
1               5                   10                  15      


Lys Thr Glu Pro Ser Ser Pro Ala Ser Leu Thr Asp Ser Val Asn His 
            20                  25                  30          


His Ser Pro Gly Gly Ser Ser Asp Ala Ser Gly Ser Tyr Ser Ser Thr 
        35                  40                  45              


Met Asn Gly His Gln Asn Gly Leu Asp Ser Pro Pro Leu Tyr Pro Ser 
    50                  55                  60                  


Ala Pro Ile Leu Gly Gly Ser Gly Pro Val Arg Lys Leu Tyr Asp Asp 
65                  70                  75                  80  


Cys Ser Ser Thr Ile Val Glu Asp Pro Gln Thr Lys Cys Glu Tyr Met 
                85                  90                  95      


Leu Asn Ser Met Pro Lys Arg Leu Cys Leu Val Cys Gly Asp Ile Ala 
            100                 105                 110         


Ser Gly Tyr His Tyr Gly Val Ala Ser Cys Glu Ala Cys Lys Ala Phe 
        115                 120                 125             


Phe Lys Arg Thr Ile Gln Gly Val Arg Leu Asp Arg Val Arg Gly Gly 
    130                 135                 140                 


Arg Gln Lys Tyr Lys Arg Arg Ile Asp Ala Glu Asn Ser Pro Tyr Leu 
145                 150                 155                 160 


Asn Pro Gln Leu Val Gln Pro Ala Lys Lys Pro Tyr Asn Lys Ile Val 
                165                 170                 175     


Ser His Leu Leu Val Ala Glu Pro Glu Lys Ile Tyr Ala Met Pro Asp 
            180                 185                 190         


Pro Thr Val Pro Asp Ser Asp Ile Lys Ala Leu Thr Thr Leu Cys Asp 
        195                 200                 205             


Leu Ala Asp Arg Glu Leu Val Val Ile Ile Gly Trp Ala Lys His Ile 
    210                 215                 220                 


Pro Gly Phe Ser Thr Leu Ser Leu Ala Asp Gln Met Ser Leu Leu Gln 
225                 230                 235                 240 


Ser Ala Trp Met Glu Ile Leu Ile Leu Gly Val Val Tyr Arg Ser Leu 
                245                 250                 255     


Ser Phe Glu Asp Glu Leu Val Tyr Ala Asp Asp Tyr Ile Met Asp Glu 
            260                 265                 270         


Asp Gln Ser Lys Leu Ala Gly Leu Leu Asp Leu Asn Asn Ala Ile Leu 
        275                 280                 285             


Gln Leu Val Lys Lys Tyr Lys Ser Met Lys Leu Glu Lys Glu Glu Phe 
    290                 295                 300                 


Val Thr Leu Lys Ala Ile Ala Leu Ala Asn Ser Asp Ser Met His Ile 
305                 310                 315                 320 


Glu Asp Val Glu Ala Val Gln Lys Leu Gln Asp Val Leu His Glu Ala 
                325                 330                 335     


Leu Gln Asp Tyr Glu Ala Gly Gln His Met Glu Asp Pro Arg Arg Ala 
            340                 345                 350         


Gly Lys Met Leu Met Thr Leu Pro Leu Leu Arg Gln Thr Ser Thr Lys 
        355                 360                 365             


Ala Val Gln His Phe Tyr Asn Ile Lys Leu Glu Gly Lys Val Pro Met 
    370                 375                 380                 


His Lys Leu Phe Leu Glu Met Leu Glu Ala Lys Val 
385                 390                 395     


<210>  3680
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESX1__Homo_sapiens__NP_703149

<400>  3680

Met Glu Ser Leu Arg Gly Tyr Thr His Ser Asp Ile Gly Tyr Arg Ser 
1               5                   10                  15      


Leu Ala Val Gly Glu Asp Ile Glu Glu Val Asn Asp Glu Lys Leu Thr 
            20                  25                  30          


Val Thr Ser Leu Met Ala Arg Gly Gly Glu Asp Glu Glu Asn Thr Arg 
        35                  40                  45              


Ser Lys Pro Glu Tyr Gly Thr Glu Ala Glu Asn Asn Val Gly Thr Glu 
    50                  55                  60                  


Gly Ser Val Pro Ser Asp Asp Gln Asp Arg Glu Gly Gly Gly Gly His 
65                  70                  75                  80  


Glu Pro Glu Gln Gln Gln Glu Glu Pro Pro Leu Thr Lys Pro Glu Gln 
                85                  90                  95      


Gln Gln Glu Glu Pro Pro Leu Leu Glu Leu Lys Gln Glu Gln Glu Glu 
            100                 105                 110         


Pro Pro Gln Thr Thr Val Glu Gly Pro Gln Pro Ala Glu Gly Pro Gln 
        115                 120                 125             


Thr Ala Glu Gly Pro Gln Pro Pro Glu Arg Lys Arg Arg Arg Arg Thr 
    130                 135                 140                 


Ala Phe Thr Gln Phe Gln Leu Gln Glu Leu Glu Asn Phe Phe Asp Glu 
145                 150                 155                 160 


Ser Gln Tyr Pro Asp Val Val Ala Arg Glu Arg Leu Ala Ala Arg Leu 
                165                 170                 175     


Asn Leu Thr Glu Asp Arg Val Gln Val Trp Phe Gln Asn Arg Arg Ala 
            180                 185                 190         


Lys Trp Lys Arg Asn Gln Arg Val Leu Met Leu Arg Asn Thr Ala Thr 
        195                 200                 205             


Ala Asp Leu Ala His Pro Leu Asp Met Phe Leu Gly Gly Ala Tyr Tyr 
    210                 215                 220                 


Ala Ala Pro Ala Leu Asp Pro Ala Leu Cys Val His Leu Val Pro Gln 
225                 230                 235                 240 


Leu Pro Arg Pro Pro Val Leu Pro Val Pro Pro Met Pro Pro Arg Pro 
                245                 250                 255     


Pro Met Val Pro Met Pro Pro Arg Pro Pro Ile Ala Pro Met Pro Pro 
            260                 265                 270         


Met Ala Pro Val Pro Pro Gly Ser Arg Met Ala Pro Val Pro Pro Gly 
        275                 280                 285             


Pro Arg Met Ala Pro Val Pro Pro Trp Pro Pro Met Ala Pro Val Pro 
    290                 295                 300                 


Pro Trp Pro Pro Met Ala Pro Val Pro Thr Gly Pro Pro Met Ala Pro 
305                 310                 315                 320 


Val Pro Pro Gly Pro Pro Met Ala Arg Val Pro Pro Gly Pro Pro Met 
                325                 330                 335     


Ala Arg Val Pro Pro Gly Pro Pro Met Ala Pro Leu Pro Pro Gly Pro 
            340                 345                 350         


Pro Met Ala Pro Leu Pro Pro Gly Pro Pro Met Ala Pro Leu Pro Pro 
        355                 360                 365             


Gly Pro Pro Met Ala Pro Leu Pro Pro Arg Ser His Val Pro His Thr 
    370                 375                 380                 


Gly Leu Ala Pro Val His Ile Thr Trp Ala Pro Val Ile Asn Ser Tyr 
385                 390                 395                 400 


Tyr Ala Cys Pro Phe Phe 
                405     


<210>  3681
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESYT1__Homo_sapiens__NP_001171725

<400>  3681

Met Glu Arg Ser Pro Gly Glu Gly Pro Ser Pro Ser Pro Met Asp Gln 
1               5                   10                  15      


Pro Ser Ala Pro Ser Asp Pro Thr Asp Gln Pro Pro Ala Ala His Ala 
            20                  25                  30          


Lys Pro Asp Pro Gly Ser Gly Gly Gln Pro Ala Gly Pro Gly Ala Ala 
        35                  40                  45              


Gly Glu Ala Leu Ala Val Leu Thr Ser Phe Gly Arg Arg Leu Leu Val 
    50                  55                  60                  


Leu Ile Pro Val Tyr Leu Ala Gly Ala Val Gly Leu Ser Val Gly Phe 
65                  70                  75                  80  


Val Leu Phe Gly Leu Ala Leu Tyr Leu Gly Trp Arg Arg Val Arg Asp 
                85                  90                  95      


Glu Lys Glu Arg Ser Leu Arg Ala Ala Arg Gln Leu Leu Asp Asp Glu 
            100                 105                 110         


Glu Gln Leu Thr Ala Lys Thr Leu Tyr Met Ser His Arg Glu Leu Pro 
        115                 120                 125             


Ala Trp Val Ser Phe Pro Asp Val Glu Lys Ala Glu Trp Leu Asn Lys 
    130                 135                 140                 


Ile Val Ala Gln Val Trp Pro Phe Leu Gly Gln Tyr Met Glu Lys Leu 
145                 150                 155                 160 


Leu Ala Glu Thr Val Ala Pro Ala Val Arg Gly Ser Asn Pro His Leu 
                165                 170                 175     


Gln Thr Phe Thr Phe Thr Arg Val Glu Leu Gly Glu Lys Pro Leu Arg 
            180                 185                 190         


Ile Ile Gly Val Lys Val His Pro Gly Gln Arg Lys Glu Gln Ile Leu 
        195                 200                 205             


Leu Asp Leu Asn Ile Ser Tyr Val Gly Asp Val Gln Ile Asp Val Glu 
    210                 215                 220                 


Val Lys Lys Tyr Phe Cys Lys Ala Gly Val Lys Gly Met Gln Leu His 
225                 230                 235                 240 


Gly Val Leu Arg Val Ile Leu Glu Pro Leu Ile Gly Asp Leu Pro Phe 
                245                 250                 255     


Val Gly Ala Val Ser Met Phe Phe Ile Arg Arg Pro Thr Leu Asp Ile 
            260                 265                 270         


Asn Trp Thr Gly Met Thr Asn Leu Leu Asp Ile Pro Gly Leu Ser Ser 
        275                 280                 285             


Leu Ser Asp Thr Met Ile Met Asp Ser Ile Ala Ala Phe Leu Val Leu 
    290                 295                 300                 


Pro Asn Arg Leu Leu Val Pro Leu Val Pro Asp Leu Gln Asp Val Ala 
305                 310                 315                 320 


Gln Leu Arg Ser Pro Leu Pro Arg Gly Ile Ile Arg Ile His Leu Leu 
                325                 330                 335     


Ala Ala Arg Gly Leu Ser Ser Lys Asp Lys Tyr Val Lys Gly Leu Ile 
            340                 345                 350         


Glu Gly Lys Ser Asp Pro Tyr Ala Leu Val Arg Leu Gly Thr Gln Thr 
        355                 360                 365             


Phe Cys Ser Arg Val Ile Asp Glu Glu Leu Asn Pro Gln Trp Gly Glu 
    370                 375                 380                 


Thr Tyr Glu Val Met Val His Glu Val Pro Gly Gln Glu Ile Glu Val 
385                 390                 395                 400 


Glu Val Phe Asp Lys Asp Pro Asp Lys Asp Asp Phe Leu Gly Arg Met 
                405                 410                 415     


Lys Leu Asp Val Gly Lys Val Leu Gln Ala Ser Val Leu Asp Asp Trp 
            420                 425                 430         


Phe Pro Leu Gln Gly Gly Gln Gly Gln Val His Leu Arg Leu Glu Trp 
        435                 440                 445             


Leu Ser Leu Leu Ser Asp Ala Glu Lys Leu Glu Gln Val Leu Gln Trp 
    450                 455                 460                 


Asn Trp Gly Val Ser Ser Arg Pro Asp Pro Pro Ser Ala Ala Ile Leu 
465                 470                 475                 480 


Val Val Tyr Leu Asp Arg Ala Gln Asp Leu Pro Met Val Thr Ser Glu 
                485                 490                 495     


Leu Tyr Pro Pro Gln Leu Lys Lys Gly Asn Lys Glu Pro Asn Pro Met 
            500                 505                 510         


Val Gln Leu Ser Ile Gln Asp Val Thr Gln Glu Ser Lys Ala Val Tyr 
        515                 520                 525             


Ser Thr Asn Cys Pro Val Trp Glu Glu Ala Phe Arg Phe Phe Leu Gln 
    530                 535                 540                 


Asp Pro Gln Ser Gln Glu Leu Asp Val Gln Val Lys Asp Asp Ser Arg 
545                 550                 555                 560 


Ala Leu Thr Leu Gly Ala Leu Thr Leu Pro Leu Ala Arg Leu Leu Thr 
                565                 570                 575     


Ala Pro Glu Leu Ile Leu Asp Gln Trp Phe Gln Leu Ser Ser Ser Gly 
            580                 585                 590         


Pro Asn Ser Arg Leu Tyr Met Lys Leu Val Met Arg Ile Leu Tyr Leu 
        595                 600                 605             


Asp Ser Ser Glu Ile Cys Phe Pro Thr Val Pro Gly Cys Pro Gly Ala 
    610                 615                 620                 


Trp Asp Val Asp Ser Glu Asn Pro Gln Arg Gly Ser Ser Val Asp Ala 
625                 630                 635                 640 


Pro Pro Arg Pro Cys His Thr Thr Pro Asp Ser Gln Phe Gly Thr Glu 
                645                 650                 655     


His Val Leu Arg Ile His Val Leu Glu Ala Gln Asp Leu Ile Ala Lys 
            660                 665                 670         


Asp Arg Phe Leu Gly Gly Leu Val Lys Gly Lys Ser Asp Pro Tyr Val 
        675                 680                 685             


Lys Leu Lys Leu Ala Gly Arg Ser Phe Arg Ser His Val Val Arg Glu 
    690                 695                 700                 


Asp Leu Asn Pro Arg Trp Asn Glu Val Phe Glu Val Ile Val Thr Ser 
705                 710                 715                 720 


Val Pro Gly Gln Glu Leu Glu Val Glu Val Phe Asp Lys Asp Leu Asp 
                725                 730                 735     


Lys Asp Asp Phe Leu Gly Arg Cys Lys Val Arg Leu Thr Thr Val Leu 
            740                 745                 750         


Asn Ser Gly Phe Leu Asp Glu Trp Leu Thr Leu Glu Asp Val Pro Ser 
        755                 760                 765             


Gly Arg Leu His Leu Arg Leu Glu Arg Leu Thr Pro Arg Pro Thr Ala 
    770                 775                 780                 


Ala Glu Leu Glu Glu Val Leu Gln Val Asn Ser Leu Ile Gln Thr Gln 
785                 790                 795                 800 


Lys Ser Ala Glu Leu Ala Ala Ala Leu Leu Ser Ile Tyr Met Glu Arg 
                805                 810                 815     


Ala Glu Asp Leu Pro Leu Arg Lys Gly Thr Lys His Leu Ser Pro Tyr 
            820                 825                 830         


Ala Thr Leu Thr Val Gly Asp Ser Ser His Lys Thr Lys Thr Ile Ser 
        835                 840                 845             


Gln Thr Ser Ala Pro Val Trp Asp Glu Ser Ala Ser Phe Leu Ile Arg 
    850                 855                 860                 


Lys Pro His Thr Glu Ser Leu Glu Leu Gln Val Arg Gly Glu Gly Thr 
865                 870                 875                 880 


Gly Val Leu Gly Ser Leu Ser Leu Pro Leu Ser Glu Leu Leu Val Ala 
                885                 890                 895     


Asp Gln Leu Cys Leu Asp Arg Trp Phe Thr Leu Ser Ser Gly Gln Gly 
            900                 905                 910         


Gln Val Leu Leu Arg Ala Gln Leu Gly Ile Leu Val Ser Gln His Ser 
        915                 920                 925             


Gly Val Glu Ala His Ser His Ser Tyr Ser His Ser Ser Ser Ser Leu 
    930                 935                 940                 


Ser Glu Glu Pro Glu Leu Ser Gly Gly Pro Pro His Ile Thr Ser Ser 
945                 950                 955                 960 


Ala Pro Glu Leu Arg Gln Arg Leu Thr His Val Asp Ser Pro Leu Glu 
                965                 970                 975     


Ala Pro Ala Gly Pro Leu Gly Gln Val Lys Leu Thr Leu Trp Tyr Tyr 
            980                 985                 990         


Ser Glu Glu Arg Lys Leu Val Ser  Ile Val His Gly Cys  Arg Ser Leu 
        995                 1000                 1005             


Arg Gln  Asn Gly Arg Asp Pro  Pro Asp Pro Tyr Val  Ser Leu Leu 
    1010                 1015                 1020             


Leu Leu  Pro Asp Lys Asn Arg  Gly Thr Lys Arg Arg  Thr Ser Gln 
    1025                 1030                 1035             


Lys Lys  Arg Thr Leu Ser Pro  Glu Phe Asn Glu Arg  Phe Glu Trp 
    1040                 1045                 1050             


Glu Leu  Pro Leu Asp Glu Ala  Gln Arg Arg Lys Leu  Asp Val Ser 
    1055                 1060                 1065             


Val Lys  Ser Asn Ser Ser Phe  Met Ser Arg Glu Arg  Glu Leu Leu 
    1070                 1075                 1080             


Gly Lys  Val Gln Leu Asp Leu  Ala Glu Thr Asp Leu  Ser Gln Gly 
    1085                 1090                 1095             


Val Ala  Arg Trp Tyr Asp Leu  Met Asp Asn Lys Asp  Lys Gly Ser 
    1100                 1105                 1110             


Ser 
    


<210>  3682
<211>  893
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESYT2__Homo_sapiens__NP_065779

<400>  3682

Met Thr Pro Pro Ser Arg Ala Glu Ala Gly Val Arg Arg Ser Arg Val 
1               5                   10                  15      


Pro Ser Glu Gly Arg Trp Arg Gly Ala Glu Pro Pro Gly Ile Ser Ala 
            20                  25                  30          


Ser Thr Gln Pro Ala Ser Ala Gly Arg Ala Ala Arg His Cys Gly Ala 
        35                  40                  45              


Met Ser Gly Ala Arg Gly Glu Gly Pro Glu Ala Gly Ala Gly Gly Ala 
    50                  55                  60                  


Gly Gly Arg Ala Ala Pro Glu Asn Pro Gly Gly Val Leu Ser Val Glu 
65                  70                  75                  80  


Leu Pro Gly Leu Leu Ala Gln Leu Ala Arg Ser Phe Ala Leu Leu Leu 
                85                  90                  95      


Pro Val Tyr Ala Leu Gly Tyr Leu Gly Leu Ser Phe Ser Trp Val Leu 
            100                 105                 110         


Leu Ala Leu Ala Leu Leu Ala Trp Cys Arg Arg Ser Arg Gly Leu Lys 
        115                 120                 125             


Ala Leu Arg Leu Cys Arg Ala Leu Ala Leu Leu Glu Asp Glu Glu Arg 
    130                 135                 140                 


Val Val Arg Leu Gly Val Arg Ala Cys Asp Leu Pro Ala Trp Val His 
145                 150                 155                 160 


Phe Pro Asp Thr Glu Arg Ala Glu Trp Leu Asn Lys Thr Val Lys His 
                165                 170                 175     


Met Trp Pro Phe Ile Cys Gln Phe Ile Glu Lys Leu Phe Arg Glu Thr 
            180                 185                 190         


Ile Glu Pro Ala Val Arg Gly Ala Asn Thr His Leu Ser Thr Phe Ser 
        195                 200                 205             


Phe Thr Lys Val Asp Val Gly Gln Gln Pro Leu Arg Ile Asn Gly Val 
    210                 215                 220                 


Lys Val Tyr Thr Glu Asn Val Asp Lys Arg Gln Ile Ile Leu Asp Leu 
225                 230                 235                 240 


Gln Ile Ser Phe Val Gly Asn Cys Glu Ile Asp Leu Glu Ile Lys Arg 
                245                 250                 255     


Tyr Phe Cys Arg Ala Gly Val Lys Ser Ile Gln Ile His Gly Thr Met 
            260                 265                 270         


Arg Val Ile Leu Glu Pro Leu Ile Gly Asp Met Pro Leu Val Gly Ala 
        275                 280                 285             


Leu Ser Ile Phe Phe Leu Arg Lys Pro Leu Leu Glu Ile Asn Trp Thr 
    290                 295                 300                 


Gly Leu Thr Asn Leu Leu Asp Val Pro Gly Leu Asn Gly Leu Ser Asp 
305                 310                 315                 320 


Thr Ile Ile Leu Asp Ile Ile Ser Asn Tyr Leu Val Leu Pro Asn Arg 
                325                 330                 335     


Ile Thr Val Pro Leu Val Ser Glu Val Gln Ile Ala Gln Leu Arg Phe 
            340                 345                 350         


Pro Val Pro Lys Gly Val Leu Arg Ile His Phe Ile Glu Ala Gln Asp 
        355                 360                 365             


Leu Gln Gly Lys Asp Thr Tyr Leu Lys Gly Leu Val Lys Gly Lys Ser 
    370                 375                 380                 


Asp Pro Tyr Gly Ile Ile Arg Val Gly Asn Gln Ile Phe Gln Ser Arg 
385                 390                 395                 400 


Val Ile Lys Glu Asn Leu Ser Pro Lys Trp Asn Glu Val Tyr Glu Ala 
                405                 410                 415     


Leu Val Tyr Glu His Pro Gly Gln Glu Leu Glu Ile Glu Leu Phe Asp 
            420                 425                 430         


Glu Asp Pro Asp Lys Asp Asp Phe Leu Gly Ser Leu Met Ile Asp Leu 
        435                 440                 445             


Ile Glu Val Glu Lys Glu Arg Leu Leu Asp Glu Trp Phe Thr Leu Asp 
    450                 455                 460                 


Glu Val Pro Lys Gly Lys Leu His Leu Arg Leu Glu Trp Leu Thr Leu 
465                 470                 475                 480 


Met Pro Asn Ala Ser Asn Leu Asp Lys Val Leu Thr Asp Ile Lys Ala 
                485                 490                 495     


Asp Lys Asp Gln Ala Asn Asp Gly Leu Ser Ser Ala Leu Leu Ile Leu 
            500                 505                 510         


Tyr Leu Asp Ser Ala Arg Asn Leu Pro Ser Gly Lys Lys Ile Ser Ser 
        515                 520                 525             


Asn Pro Asn Pro Val Val Gln Met Ser Val Gly His Lys Ala Gln Glu 
    530                 535                 540                 


Ser Lys Ile Arg Tyr Lys Thr Asn Glu Pro Val Trp Glu Glu Asn Phe 
545                 550                 555                 560 


Thr Phe Phe Ile His Asn Pro Lys Arg Gln Asp Leu Glu Val Glu Val 
                565                 570                 575     


Arg Asp Glu Gln His Gln Cys Ser Leu Gly Asn Leu Lys Val Pro Leu 
            580                 585                 590         


Ser Gln Leu Leu Thr Ser Glu Asp Met Thr Val Ser Gln Arg Phe Gln 
        595                 600                 605             


Leu Ser Asn Ser Gly Pro Asn Ser Thr Ile Lys Met Lys Ile Ala Leu 
    610                 615                 620                 


Arg Val Leu His Leu Glu Lys Arg Glu Arg Pro Pro Asp His Gln His 
625                 630                 635                 640 


Ser Ala Gln Val Lys Arg Pro Ser Val Ser Lys Glu Gly Arg Lys Thr 
                645                 650                 655     


Ser Ile Lys Ser His Met Ser Gly Ser Pro Gly Pro Gly Gly Ser Asn 
            660                 665                 670         


Thr Ala Pro Ser Thr Pro Val Ile Gly Gly Ser Asp Lys Pro Gly Met 
        675                 680                 685             


Glu Glu Lys Ala Gln Pro Pro Glu Ala Gly Pro Gln Gly Leu His Asp 
    690                 695                 700                 


Leu Gly Arg Ser Ser Ser Ser Leu Leu Ala Ser Pro Gly His Ile Ser 
705                 710                 715                 720 


Val Lys Glu Pro Thr Pro Ser Ile Ala Ser Asp Ile Ser Leu Pro Ile 
                725                 730                 735     


Ala Thr Gln Glu Leu Arg Gln Arg Leu Arg Gln Leu Glu Asn Gly Thr 
            740                 745                 750         


Thr Leu Gly Gln Ser Pro Leu Gly Gln Ile Gln Leu Thr Ile Arg His 
        755                 760                 765             


Ser Ser Gln Arg Asn Lys Leu Ile Val Val Val His Ala Cys Arg Asn 
    770                 775                 780                 


Leu Ile Ala Phe Ser Glu Asp Gly Ser Asp Pro Tyr Val Arg Met Tyr 
785                 790                 795                 800 


Leu Leu Pro Asp Lys Arg Arg Ser Gly Arg Arg Lys Thr His Val Ser 
                805                 810                 815     


Lys Lys Thr Leu Asn Pro Val Phe Asp Gln Ser Phe Asp Phe Ser Val 
            820                 825                 830         


Ser Leu Pro Glu Val Gln Arg Arg Thr Leu Asp Val Ala Val Lys Asn 
        835                 840                 845             


Ser Gly Gly Phe Leu Ser Lys Asp Lys Gly Leu Leu Gly Lys Val Leu 
    850                 855                 860                 


Val Ala Leu Ala Ser Glu Glu Leu Ala Lys Gly Trp Thr Gln Trp Tyr 
865                 870                 875                 880 


Asp Leu Thr Glu Asp Gly Thr Arg Pro Gln Ala Met Thr 
                885                 890             


<210>  3683
<211>  886
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ESYT3__Homo_sapiens__NP_114119

<400>  3683

Met Arg Ala Glu Glu Pro Cys Ala Pro Gly Ala Pro Ser Ala Leu Gly 
1               5                   10                  15      


Ala Gln Arg Thr Pro Gly Pro Glu Leu Arg Leu Ser Ser Gln Leu Leu 
            20                  25                  30          


Pro Glu Leu Cys Thr Phe Val Val Arg Val Leu Phe Tyr Leu Gly Pro 
        35                  40                  45              


Val Tyr Leu Ala Gly Tyr Leu Gly Leu Ser Ile Thr Trp Leu Leu Leu 
    50                  55                  60                  


Gly Ala Leu Leu Trp Met Trp Trp Arg Arg Asn Arg Arg Gly Lys Leu 
65                  70                  75                  80  


Gly Arg Leu Ala Ala Ala Phe Glu Phe Leu Asp Asn Glu Arg Glu Phe 
                85                  90                  95      


Ile Ser Arg Glu Leu Arg Gly Gln His Leu Pro Ala Trp Ile His Phe 
            100                 105                 110         


Pro Asp Val Glu Arg Val Glu Trp Ala Asn Lys Ile Ile Ser Gln Thr 
        115                 120                 125             


Trp Pro Tyr Leu Ser Met Ile Met Glu Ser Lys Phe Arg Glu Lys Leu 
    130                 135                 140                 


Glu Pro Lys Ile Arg Glu Lys Ser Ile His Leu Arg Thr Phe Thr Phe 
145                 150                 155                 160 


Thr Lys Leu Tyr Phe Gly Gln Lys Cys Pro Arg Val Asn Gly Val Lys 
                165                 170                 175     


Ala His Thr Asn Thr Cys Asn Arg Arg Arg Val Thr Val Asp Leu Gln 
            180                 185                 190         


Ile Cys Tyr Ile Gly Asp Cys Glu Ile Ser Val Glu Leu Gln Lys Ile 
        195                 200                 205             


Gln Ala Gly Val Asn Gly Ile Gln Leu Gln Gly Thr Leu Arg Val Ile 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Asp Lys Pro Phe Val Gly Ala Val Thr Val 
225                 230                 235                 240 


Phe Phe Leu Gln Lys Pro His Leu Gln Ile Asn Trp Thr Gly Leu Thr 
                245                 250                 255     


Asn Leu Leu Asp Ala Pro Gly Ile Asn Asp Val Ser Asp Ser Leu Leu 
            260                 265                 270         


Glu Asp Leu Ile Ala Thr His Leu Val Leu Pro Asn Arg Val Thr Val 
        275                 280                 285             


Pro Val Lys Lys Gly Leu Asp Leu Thr Asn Leu Arg Phe Pro Leu Pro 
    290                 295                 300                 


Cys Gly Val Ile Arg Val His Leu Leu Glu Ala Glu Gln Leu Ala Gln 
305                 310                 315                 320 


Lys Asp Asn Phe Leu Gly Leu Arg Gly Lys Ser Asp Pro Tyr Ala Lys 
                325                 330                 335     


Val Ser Ile Gly Leu Gln His Phe Arg Ser Arg Thr Ile Tyr Arg Asn 
            340                 345                 350         


Leu Asn Pro Thr Trp Asn Glu Val Phe Glu Phe Met Val Tyr Glu Val 
        355                 360                 365             


Pro Gly Gln Asp Leu Glu Val Asp Leu Tyr Asp Glu Asp Thr Asp Arg 
    370                 375                 380                 


Asp Asp Phe Leu Gly Ser Leu Gln Ile Cys Leu Gly Asp Val Met Thr 
385                 390                 395                 400 


Asn Arg Val Val Asp Glu Trp Phe Val Leu Asn Asp Thr Thr Ser Gly 
                405                 410                 415     


Arg Leu His Leu Arg Leu Glu Trp Leu Ser Leu Leu Thr Asp Gln Glu 
            420                 425                 430         


Val Leu Thr Glu Asp His Gly Gly Leu Ser Thr Ala Ile Leu Val Val 
        435                 440                 445             


Phe Leu Glu Ser Ala Cys Asn Leu Pro Arg Asn Pro Phe Asp Tyr Leu 
    450                 455                 460                 


Asn Gly Glu Tyr Arg Ala Lys Lys Leu Ser Arg Phe Ala Arg Asn Lys 
465                 470                 475                 480 


Val Ser Lys Asp Pro Ser Ser Tyr Val Lys Leu Ser Val Gly Lys Lys 
                485                 490                 495     


Thr His Thr Ser Lys Thr Cys Pro His Asn Lys Asp Pro Val Trp Ser 
            500                 505                 510         


Gln Val Phe Ser Phe Phe Val His Asn Val Ala Thr Glu Arg Leu His 
        515                 520                 525             


Leu Lys Val Leu Asp Asp Asp Gln Glu Cys Ala Leu Gly Met Leu Glu 
    530                 535                 540                 


Val Pro Leu Cys Gln Ile Leu Pro Tyr Ala Asp Leu Thr Leu Glu Gln 
545                 550                 555                 560 


Arg Phe Gln Leu Asp His Ser Gly Leu Asp Ser Leu Ile Ser Met Arg 
                565                 570                 575     


Leu Val Leu Arg Phe Leu Gln Val Glu Glu Arg Glu Leu Gly Ser Pro 
            580                 585                 590         


Tyr Thr Gly Pro Glu Ala Leu Lys Lys Gly Pro Leu Leu Ile Lys Lys 
        595                 600                 605             


Val Ala Thr Asn Gln Gly Pro Lys Ala Gln Pro Gln Glu Glu Gly Pro 
    610                 615                 620                 


Thr Asp Leu Pro Cys Pro Pro Asp Pro Ala Ser Asp Thr Lys Asp Val 
625                 630                 635                 640 


Ser Arg Ser Thr Thr Thr Thr Thr Ser Ala Thr Thr Val Ala Thr Glu 
                645                 650                 655     


Pro Thr Ser Gln Glu Thr Gly Pro Glu Pro Lys Gly Lys Asp Ser Ala 
            660                 665                 670         


Lys Arg Phe Cys Glu Pro Ile Gly Glu Lys Lys Ser Pro Ala Thr Ile 
        675                 680                 685             


Phe Leu Thr Val Pro Gly Pro His Ser Pro Gly Pro Ile Lys Ser Pro 
    690                 695                 700                 


Arg Pro Met Lys Cys Pro Ala Ser Pro Phe Ala Trp Pro Pro Lys Arg 
705                 710                 715                 720 


Leu Ala Pro Ser Met Ser Ser Leu Asn Ser Leu Ala Ser Ser Cys Phe 
                725                 730                 735     


Asp Leu Ala Asp Ile Ser Leu Asn Ile Glu Gly Gly Asp Leu Arg Arg 
            740                 745                 750         


Arg Gln Leu Gly Glu Ile Gln Leu Thr Val Arg Tyr Val Cys Leu Arg 
        755                 760                 765             


Arg Cys Leu Ser Val Leu Ile Asn Gly Cys Arg Asn Leu Thr Pro Cys 
    770                 775                 780                 


Thr Ser Ser Gly Ala Asp Pro Tyr Val Arg Val Tyr Leu Leu Pro Glu 
785                 790                 795                 800 


Arg Lys Trp Ala Cys Arg Lys Lys Thr Ser Val Lys Arg Lys Thr Leu 
                805                 810                 815     


Glu Pro Leu Phe Asp Glu Thr Phe Glu Phe Phe Val Pro Met Glu Glu 
            820                 825                 830         


Val Lys Lys Arg Ser Leu Asp Val Ala Val Lys Asn Ser Arg Pro Leu 
        835                 840                 845             


Gly Ser His Arg Arg Lys Glu Leu Gly Lys Val Leu Ile Asp Leu Ser 
    850                 855                 860                 


Lys Glu Asp Leu Ile Lys Gly Phe Ser Gln Trp Tyr Glu Leu Thr Pro 
865                 870                 875                 880 


Asn Gly Gln Pro Arg Ser 
                885     


<210>  3684
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETAA1__Homo_sapiens__NP_061875

<400>  3684

Met Ser Arg Arg Arg Lys His Asp Asp Ser Pro Ser Pro Lys Lys Thr 
1               5                   10                  15      


Pro His Lys Thr Val Ala Ala Glu Glu Cys Gly Ser Val Val Glu Pro 
            20                  25                  30          


Gly Arg Arg Arg Leu Arg Ser Ala Arg Gly Ser Trp Pro Cys Gly Ala 
        35                  40                  45              


Arg Glu Gly Pro Pro Gly Pro Val Arg Gln Arg Glu Gln Pro Pro Thr 
    50                  55                  60                  


Ala Ala Leu Cys Ser Lys Ser Asn Pro Glu Glu Arg Tyr Glu Thr Pro 
65                  70                  75                  80  


Lys Arg Ala Leu Lys Met Asp Ser Leu Ser Ser Ser Phe Ser Ser Pro 
                85                  90                  95      


Asn Asp Pro Asp Gly Gln Asn Asp Ile Phe Trp Asp Gln Asn Ser Pro 
            100                 105                 110         


Leu Thr Lys Gln Leu Gly Lys Gly Arg Lys Lys Gln Ile Tyr Thr Thr 
        115                 120                 125             


Asp Ser Asp Glu Ile Ser His Ile Val Asn Arg Ile Ala Pro Gln Asp 
    130                 135                 140                 


Glu Lys Pro Thr Thr Asn Ser Met Leu Asp Met Trp Ile Gly Glu Thr 
145                 150                 155                 160 


Ala Ile Pro Cys Thr Pro Ser Val Ala Lys Gly Lys Ser Arg Ala Lys 
                165                 170                 175     


Ile Ser Cys Thr Lys Leu Lys Thr Gln Ser Gln Glu Glu Glu Leu Met 
            180                 185                 190         


Lys Leu Ala Lys Gln Phe Asp Lys Asn Met Glu Glu Leu Asp Val Ile 
        195                 200                 205             


Gln Glu Gln Asn Lys Arg Asn Tyr Asp Phe Thr Gln Met Ile Ser Glu 
    210                 215                 220                 


Thr Glu Ile Leu Ser Asn Tyr Lys Asp Asn Ile Gln Met Trp Ser Leu 
225                 230                 235                 240 


His Asn Ile Val Pro Glu Ile Asp Asn Ala Thr Lys Lys Pro Ile Lys 
                245                 250                 255     


Gly Asn Thr Lys Ile Ser Val Ala Asn Asn Gln Asn Ser Ser Gln Lys 
            260                 265                 270         


Pro Phe Asp Gln Ile Ala Glu Ala Ala Phe Asn Ala Ile Phe Asp Gly 
        275                 280                 285             


Ser Thr Gln Lys Cys Ser Gly Gln Leu Ser Gln Glu Leu Pro Glu Ala 
    290                 295                 300                 


Phe Trp Ser Thr Ser Asn Thr Thr Phe Val Lys Thr Asn Ala Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ile Ile Thr Asn Glu Thr Leu Val Ile Glu Lys Leu Ser 
                325                 330                 335     


Asn Lys Thr Pro Arg Ser Leu Ser Ser Gln Val Asp Thr Pro Ile Met 
            340                 345                 350         


Thr Lys Ser Cys Val Thr Ser Cys Thr Lys Glu Pro Glu Thr Ser Asn 
        355                 360                 365             


Lys Tyr Ile Asp Ala Phe Thr Thr Ser Asp Phe Glu Asp Asp Trp Glu 
    370                 375                 380                 


Asn Leu Leu Gly Ser Glu Pro Phe Ala Met Gln Asn Ile Asp Met Pro 
385                 390                 395                 400 


Glu Leu Phe Pro Ser Lys Thr Ala His Val Thr Asp Gln Lys Glu Ile 
                405                 410                 415     


Cys Thr Phe Asn Ser Lys Thr Val Lys Asn Thr Ser Arg Ala Asn Thr 
            420                 425                 430         


Ser Pro Asp Ala Arg Leu Gly Asp Ser Lys Val Leu Gln Asp Leu Ser 
        435                 440                 445             


Ser Lys Thr Tyr Asp Arg Glu Leu Ile Asp Ala Glu Tyr Arg Phe Ser 
    450                 455                 460                 


Pro Asn Ser Asn Lys Ser Asn Lys Leu Ser Thr Gly Asn Lys Met Lys 
465                 470                 475                 480 


Phe Glu Asn Ser Ser Asn Lys Ile Val Ile Gln Asp Glu Ile Gln Asn 
                485                 490                 495     


Cys Ile Val Thr Ser Asn Leu Thr Lys Ile Lys Glu Asp Ile Leu Thr 
            500                 505                 510         


Asn Ser Thr Glu Ala Ser Glu Arg Lys Ser Ala Leu Asn Thr Arg Tyr 
        515                 520                 525             


Ser Asn Glu Gln Lys Asn Lys Cys Ile Leu Asn Gln Ser Ile Lys Ala 
    530                 535                 540                 


Pro Val Asn Thr Asp Leu Phe Gly Ser Ala Asn Leu Gly Ser Lys Thr 
545                 550                 555                 560 


Ser Val Ser Asn Pro Asn Gln Thr Ser Ala Ser Lys Val Gly Ser Phe 
                565                 570                 575     


Phe Asp Asp Trp Asn Asp Pro Ser Phe Ala Asn Glu Ile Ile Lys Ala 
            580                 585                 590         


Cys His Gln Leu Asp Asn Thr Trp Glu Ala Asp Asp Val Asp Asp Asp 
        595                 600                 605             


Leu Leu Tyr Gln Ala Cys Asp Asp Ile Glu Arg Leu Thr Gln Gln Gln 
    610                 615                 620                 


Asp Ile Arg Lys Asp Ser Lys Thr Ser Glu Ser Ile Cys Glu Ile Asn 
625                 630                 635                 640 


Asn Asn Ser Glu His Gly Ala Lys Leu Thr Gln Gln Gln Asp Ile Arg 
                645                 650                 655     


Lys Asp Ser Lys Thr Ser Glu Ser Ile Cys Glu Ile Asn Asn Asn Ser 
            660                 665                 670         


Glu His Gly Ala Lys Asn Met Phe Ala Ile Ser Lys Gln Gly Ser Asn 
        675                 680                 685             


Leu Val Gln Ser Lys His Leu Asn Pro Gly Ser Ile Ser Val Gln Thr 
    690                 695                 700                 


Ser Leu Thr Asn Ser Ser Gln Ile Asp Lys Pro Met Lys Met Glu Lys 
705                 710                 715                 720 


Gly Glu Met Tyr Gly Asn Ser Pro Arg Phe Leu Gly Ala Thr Asn Leu 
                725                 730                 735     


Thr Met Tyr Ser Lys Ile Ser Asn Cys Gln Ile Asn Asn Leu His Val 
            740                 745                 750         


Ser Tyr Thr Asn Thr Asp Val Pro Ile Gln Val Asn Ser Ser Lys Leu 
        755                 760                 765             


Val Leu Pro Gly Ser Ser Ser Leu Asn Val Thr Ser Asp His Met Asn 
    770                 775                 780                 


Thr Glu Ile Thr Thr Tyr Lys Lys Lys Leu Ser Thr Asn Gln Pro Cys 
785                 790                 795                 800 


His Lys Thr Val Thr Asp Glu Ala Gln Ser Asn Leu Asn Thr Thr Val 
                805                 810                 815     


Gly Phe Ser Lys Phe Thr Phe Thr Arg Met Lys Asn Ser Gln Ile Leu 
            820                 825                 830         


Ser Gln Phe Asn Gln Asn Cys Ile Thr Gly Ser Met Ser Asp Thr Lys 
        835                 840                 845             


Ile Thr Gln Gly Val Glu Lys Lys Lys Gly Val Asn Pro Leu Leu Glu 
    850                 855                 860                 


Glu Ala Val Gly Gln Gln Ser Leu Val Lys Leu Ser Glu Ser Leu Lys 
865                 870                 875                 880 


Gln Ser Ser Lys Glu Glu Glu Glu Lys Asn Arg Lys Cys Ser Pro Glu 
                885                 890                 895     


Glu Ile Gln Arg Lys Arg Gln Glu Ala Leu Val Arg Arg Met Ala Lys 
            900                 905                 910         


Ala Arg Ala Ser Ser Val Asn Ala Ala Pro Thr Ser Phe Leu 
        915                 920                 925     


<210>  3685
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETF1__Homo_sapiens__NP_001269114

<400>  3685

Met Lys Gln Asp Val Leu Asn Cys Thr Glu Gly Pro Ile His Ser Asn 
1               5                   10                  15      


Gly Thr Ser Met Ile Ser Leu Ile Ile Pro Pro Lys Asp Gln Ile Ser 
            20                  25                  30          


Arg Val Ala Lys Met Leu Ala Asp Glu Phe Gly Thr Ala Ser Asn Ile 
        35                  40                  45              


Lys Ser Arg Val Asn Arg Leu Ser Val Leu Gly Ala Ile Thr Ser Val 
    50                  55                  60                  


Gln Gln Arg Leu Lys Leu Tyr Asn Lys Val Pro Pro Asn Gly Leu Val 
65                  70                  75                  80  


Val Tyr Cys Gly Thr Ile Val Thr Glu Glu Gly Lys Glu Lys Lys Val 
                85                  90                  95      


Asn Ile Asp Phe Glu Pro Phe Lys Pro Ile Asn Thr Ser Leu Tyr Leu 
            100                 105                 110         


Cys Asp Asn Lys Phe His Thr Glu Ala Leu Thr Ala Leu Leu Ser Asp 
        115                 120                 125             


Asp Ser Lys Phe Gly Phe Ile Val Ile Asp Gly Ser Gly Ala Leu Phe 
    130                 135                 140                 


Gly Thr Leu Gln Gly Asn Thr Arg Glu Val Leu His Lys Phe Thr Val 
145                 150                 155                 160 


Asp Leu Pro Lys Lys His Gly Arg Gly Gly Gln Ser Ala Leu Arg Phe 
                165                 170                 175     


Ala Arg Leu Arg Met Glu Lys Arg His Asn Tyr Val Arg Lys Val Ala 
            180                 185                 190         


Glu Thr Ala Val Gln Leu Phe Ile Ser Gly Asp Lys Val Asn Val Ala 
        195                 200                 205             


Gly Leu Val Leu Ala Gly Ser Ala Asp Phe Lys Thr Glu Leu Ser Gln 
    210                 215                 220                 


Ser Asp Met Phe Asp Gln Arg Leu Gln Ser Lys Val Leu Lys Leu Val 
225                 230                 235                 240 


Asp Ile Ser Tyr Gly Gly Glu Asn Gly Phe Asn Gln Ala Ile Glu Leu 
                245                 250                 255     


Ser Thr Glu Val Leu Ser Asn Val Lys Phe Ile Gln Glu Lys Lys Leu 
            260                 265                 270         


Ile Gly Arg Tyr Phe Asp Glu Ile Ser Gln Asp Thr Gly Lys Tyr Cys 
        275                 280                 285             


Phe Gly Val Glu Asp Thr Leu Lys Ala Leu Glu Met Gly Ala Val Glu 
    290                 295                 300                 


Ile Leu Ile Val Tyr Glu Asn Leu Asp Ile Met Arg Tyr Val Leu His 
305                 310                 315                 320 


Cys Gln Gly Thr Glu Glu Glu Lys Ile Leu Tyr Leu Thr Pro Glu Gln 
                325                 330                 335     


Glu Lys Asp Lys Ser His Phe Thr Asp Lys Glu Thr Gly Gln Glu His 
            340                 345                 350         


Glu Leu Ile Glu Ser Met Pro Leu Leu Glu Trp Phe Ala Asn Asn Tyr 
        355                 360                 365             


Lys Lys Phe Gly Ala Thr Leu Glu Ile Val Thr Asp Lys Ser Gln Glu 
    370                 375                 380                 


Gly Ser Gln Phe Val Lys Gly Phe Gly Gly Ile Gly Gly Ile Leu Arg 
385                 390                 395                 400 


Tyr Arg Val Asp Phe Gln Gly Met Glu Tyr Gln Gly Gly Asp Asp Glu 
                405                 410                 415     


Phe Phe Asp Leu Asp Asp Tyr 
            420             


<210>  3686
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETFA__Homo_sapiens__NP_000117

<400>  3686

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
1               5                   10                  15      


Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
            20                  25                  30          


Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
        35                  40                  45              


Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
    50                  55                  60                  


Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
65                  70                  75                  80  


His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                85                  90                  95      


Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
            100                 105                 110         


Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
        115                 120                 125             


Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
    130                 135                 140                 


Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
145                 150                 155                 160 


Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                165                 170                 175     


Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
            180                 185                 190         


Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
        195                 200                 205             


Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
    210                 215                 220                 


Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
225                 230                 235                 240 


Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                245                 250                 255     


Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
            260                 265                 270         


Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
        275                 280                 285             


Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
    290                 295                 300                 


Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
305                 310                 315                 320 


Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                325                 330             


<210>  3687
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETFB__Homo_sapiens__NP_001014763

<400>  3687

Met Tyr Leu Ser Leu Trp Val Thr Ile Asn Thr Val Asn Leu Arg Asn 
1               5                   10                  15      


Thr Leu Ser Gly Leu Arg Gly Ala Val Thr Thr Val Gly Met Ile Lys 
            20                  25                  30          


Ser Asp Val Pro Gly Thr Gln Glu Trp Leu Asp Glu Arg Arg Arg Gln 
        35                  40                  45              


Gly Asp Leu Pro Leu Pro Thr Asn Ser Asn Pro Val Leu Ser Leu Glu 
    50                  55                  60                  


Leu Cys Asp Pro Gly Gln Gly Pro Ala Pro Phe Gln Ala Val Val Val 
65                  70                  75                  80  


Leu Ile Gln Pro Gly Arg Gly Leu Ala Leu Arg Pro Pro Pro Ser Cys 
                85                  90                  95      


Leu Phe Pro Pro Asp Pro Thr Pro Ser Pro Pro Ala Gly Gln Ile Arg 
            100                 105                 110         


Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp Gly Val Lys His Ser 
        115                 120                 125             


Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu Ala Val Arg Leu Lys 
    130                 135                 140                 


Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val Ser Cys Gly Pro Ala 
145                 150                 155                 160 


Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala Met Gly Ala Asp Arg 
                165                 170                 175     


Gly Ile His Val Glu Val Pro Pro Ala Glu Ala Glu Arg Leu Gly Pro 
            180                 185                 190         


Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala Glu Lys Glu Lys Val 
        195                 200                 205             


Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp Asp Asp Cys Asn Gln 
    210                 215                 220                 


Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp Pro Gln Gly Thr Phe 
225                 230                 235                 240 


Ala Ser Gln Val Thr Leu Glu Gly Asp Lys Leu Lys Val Glu Arg Glu 
                245                 250                 255     


Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys Leu Pro Ala Val Val 
            260                 265                 270         


Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr Ala Thr Leu Pro Asn 
        275                 280                 285             


Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val Ile Lys Pro Gly Asp 
    290                 295                 300                 


Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val Ile Ser Val Glu Asp 
305                 310                 315                 320 


Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu Thr Thr Glu Asp Leu 
                325                 330                 335     


Val Ala Lys Leu Lys Glu Ile Gly Arg Ile 
            340                 345     


<210>  3688
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETFDH__Homo_sapiens__NP_001268666

<400>  3688

Met Leu Val Pro Leu Ala Lys Leu Ser Cys Leu Gly Val Asn Met Glu 
1               5                   10                  15      


Arg Phe Ala Glu Glu Ala Asp Val Val Ile Val Gly Ala Gly Pro Ala 
            20                  25                  30          


Gly Leu Ser Ala Ala Val Arg Leu Lys Gln Leu Ala Val Ala His Glu 
        35                  40                  45              


Lys Asp Ile Arg Val Cys Leu Val Glu Lys Ala Ala Gln Ile Gly Ala 
    50                  55                  60                  


His Thr Leu Ser Gly Ala Cys Leu Asp Pro Gly Ala Phe Lys Glu Leu 
65                  70                  75                  80  


Phe Pro Asp Trp Lys Glu Lys Gly Ala Pro Leu Asn Thr Pro Val Thr 
                85                  90                  95      


Glu Asp Arg Phe Gly Ile Leu Thr Glu Lys Tyr Arg Ile Pro Val Pro 
            100                 105                 110         


Ile Leu Pro Gly Leu Pro Met Asn Asn His Gly Asn Tyr Ile Val Arg 
        115                 120                 125             


Leu Gly His Leu Val Ser Trp Met Gly Glu Gln Ala Glu Ala Leu Gly 
    130                 135                 140                 


Val Glu Val Tyr Pro Gly Tyr Ala Ala Ala Glu Val Leu Phe His Asp 
145                 150                 155                 160 


Asp Gly Ser Val Lys Gly Ile Ala Thr Asn Asp Val Gly Ile Gln Lys 
                165                 170                 175     


Asp Gly Ala Pro Lys Ala Thr Phe Glu Arg Gly Leu Glu Leu His Ala 
            180                 185                 190         


Lys Val Thr Ile Phe Ala Glu Gly Cys His Gly His Leu Ala Lys Gln 
        195                 200                 205             


Leu Tyr Lys Lys Phe Asp Leu Arg Ala Asn Cys Glu Pro Gln Thr Tyr 
    210                 215                 220                 


Gly Ile Gly Leu Lys Glu Leu Trp Val Ile Asp Glu Lys Asn Trp Lys 
225                 230                 235                 240 


Pro Gly Arg Val Asp His Thr Val Gly Trp Pro Leu Asp Arg His Thr 
                245                 250                 255     


Tyr Gly Gly Ser Phe Leu Tyr His Leu Asn Glu Gly Glu Pro Leu Val 
            260                 265                 270         


Ala Leu Gly Leu Val Val Gly Leu Asp Tyr Gln Asn Pro Tyr Leu Ser 
        275                 280                 285             


Pro Phe Arg Glu Phe Gln Arg Trp Lys His His Pro Ser Ile Arg Pro 
    290                 295                 300                 


Thr Leu Glu Gly Gly Lys Arg Ile Ala Tyr Gly Ala Arg Ala Leu Asn 
305                 310                 315                 320 


Glu Gly Gly Phe Gln Ser Ile Pro Lys Leu Thr Phe Pro Gly Gly Leu 
                325                 330                 335     


Leu Ile Gly Cys Ser Pro Gly Phe Met Asn Val Pro Lys Ile Lys Gly 
            340                 345                 350         


Thr His Thr Ala Met Lys Ser Gly Ile Leu Ala Ala Glu Ser Ile Phe 
        355                 360                 365             


Asn Gln Leu Thr Ser Glu Asn Leu Gln Ser Lys Thr Ile Gly Leu His 
    370                 375                 380                 


Val Thr Glu Tyr Glu Asp Asn Leu Lys Asn Ser Trp Val Trp Lys Glu 
385                 390                 395                 400 


Leu Tyr Ser Val Arg Asn Ile Arg Pro Ser Cys His Gly Val Leu Gly 
                405                 410                 415     


Val Tyr Gly Gly Met Ile Tyr Thr Gly Ile Phe Tyr Trp Ile Leu Arg 
            420                 425                 430         


Gly Met Glu Pro Trp Thr Leu Lys His Lys Gly Ser Asp Phe Glu Arg 
        435                 440                 445             


Leu Lys Pro Ala Lys Asp Cys Thr Pro Ile Glu Tyr Pro Lys Pro Asp 
    450                 455                 460                 


Gly Gln Ile Ser Phe Asp Leu Leu Ser Ser Val Ala Leu Ser Gly Thr 
465                 470                 475                 480 


Asn His Glu His Asp Gln Pro Ala His Leu Thr Leu Arg Asp Asp Ser 
                485                 490                 495     


Ile Pro Val Asn Arg Asn Leu Ser Ile Tyr Asp Gly Pro Glu Gln Arg 
            500                 505                 510         


Phe Cys Pro Ala Gly Val Tyr Glu Phe Val Pro Val Glu Gln Gly Asp 
        515                 520                 525             


Gly Phe Arg Leu Gln Ile Asn Ala Gln Asn Cys Val His Cys Lys Thr 
    530                 535                 540                 


Cys Asp Ile Lys Asp Pro Ser Gln Asn Ile Asn Trp Val Val Pro Glu 
545                 550                 555                 560 


Gly Gly Gly Gly Pro Ala Tyr Asn Gly Met 
                565                 570 


<210>  3689
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETHE1__Homo_sapiens__NP_055112

<400>  3689

Met Ala Glu Ala Val Leu Arg Val Ala Arg Arg Gln Leu Ser Gln Arg 
1               5                   10                  15      


Gly Gly Ser Gly Ala Pro Ile Leu Leu Arg Gln Met Phe Glu Pro Val 
            20                  25                  30          


Ser Cys Thr Phe Thr Tyr Leu Leu Gly Asp Arg Glu Ser Arg Glu Ala 
        35                  40                  45              


Val Leu Ile Asp Pro Val Leu Glu Thr Ala Pro Arg Asp Ala Gln Leu 
    50                  55                  60                  


Ile Lys Glu Leu Gly Leu Arg Leu Leu Tyr Ala Val Asn Thr His Cys 
65                  70                  75                  80  


His Ala Asp His Ile Thr Gly Ser Gly Leu Leu Arg Ser Leu Leu Pro 
                85                  90                  95      


Gly Cys Gln Ser Val Ile Ser Arg Leu Ser Gly Ala Gln Ala Asp Leu 
            100                 105                 110         


His Ile Glu Asp Gly Asp Ser Ile Arg Phe Gly Arg Phe Ala Leu Glu 
        115                 120                 125             


Thr Arg Ala Ser Pro Gly His Thr Pro Gly Cys Val Thr Phe Val Leu 
    130                 135                 140                 


Asn Asp His Ser Met Ala Phe Thr Gly Asp Ala Leu Leu Ile Arg Gly 
145                 150                 155                 160 


Cys Gly Arg Thr Asp Phe Gln Gln Gly Cys Ala Lys Thr Leu Tyr His 
                165                 170                 175     


Ser Val His Glu Lys Ile Phe Thr Leu Pro Gly Asp Cys Leu Ile Tyr 
            180                 185                 190         


Pro Ala His Asp Tyr His Gly Phe Thr Val Ser Thr Val Glu Glu Glu 
        195                 200                 205             


Arg Thr Leu Asn Pro Arg Leu Thr Leu Ser Cys Glu Glu Phe Val Lys 
    210                 215                 220                 


Ile Met Gly Asn Leu Asn Leu Pro Lys Pro Gln Gln Ile Asp Phe Ala 
225                 230                 235                 240 


Val Pro Ala Asn Met Arg Cys Gly Val Gln Thr Pro Thr Ala 
                245                 250                 


<210>  3690
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETNK1__Homo_sapiens__NP_001034570

<400>  3690

Met Leu Cys Gly Arg Pro Arg Ser Ser Ser Asp Asn Arg Asn Phe Leu 
1               5                   10                  15      


Arg Glu Arg Ala Gly Leu Ser Ser Ala Ala Val Gln Thr Arg Ile Gly 
            20                  25                  30          


Asn Ser Ala Ala Ser Arg Arg Ser Pro Ala Ala Arg Pro Pro Val Pro 
        35                  40                  45              


Ala Pro Pro Ala Leu Pro Arg Gly Arg Pro Gly Thr Glu Gly Ser Thr 
    50                  55                  60                  


Ser Leu Ser Ala Pro Ala Val Leu Val Val Ala Val Ala Val Val Val 
65                  70                  75                  80  


Val Val Val Ser Ala Val Ala Trp Ala Met Ala Asn Tyr Ile His Val 
                85                  90                  95      


Pro Pro Gly Ser Pro Glu Val Pro Lys Leu Asn Val Thr Val Gln Asp 
            100                 105                 110         


Gln Glu Glu His Arg Cys Arg Glu Gly Ala Leu Ser Leu Leu Gln His 
        115                 120                 125             


Leu Arg Pro His Trp Asp Pro Gln Glu Val Thr Leu Gln Leu Phe Thr 
    130                 135                 140                 


Asp Gly Ile Thr Asn Lys Leu Ile Gly Cys Tyr Val Gly Asn Thr Met 
145                 150                 155                 160 


Glu Asp Val Val Leu Val Arg Ile Tyr Gly Asn Lys Thr Glu Leu Leu 
                165                 170                 175     


Val Asp Arg Asp Glu Glu Val Lys Ser Phe Arg Val Leu Gln Ala His 
            180                 185                 190         


Gly Cys Ala Pro Gln Leu Tyr Cys Thr Phe Asn Asn Gly Leu Cys Tyr 
        195                 200                 205             


Glu Phe Ile Gln Gly Glu Ala Leu Asp Pro Lys His Val Cys Asn Pro 
    210                 215                 220                 


Ala Ile Phe Ser Leu Ser Ser Leu Thr Leu Cys Lys Gly Lys Thr Thr 
225                 230                 235                 240 


Arg Cys Phe Gly Leu Thr Gly Cys Arg Gly Ser Arg Leu Leu Leu Ser 
                245                 250                 255     


Phe Phe 
        


<210>  3691
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETNK2__Homo_sapiens__NP_001284689

<400>  3691

Met Ala Val Pro Pro Ser Ala Pro Gln Pro Arg Ala Ser Phe His Leu 
1               5                   10                  15      


Arg Arg His Thr Pro Cys Pro Gln Cys Ser Trp Gly Met Glu Glu Lys 
            20                  25                  30          


Ala Ala Ala Ser Ala Ser Cys Arg Glu Pro Pro Gly Pro Pro Arg Ala 
        35                  40                  45              


Ala Ala Val Ala Tyr Phe Gly Ile Ser Val Asp Pro Asp Asp Ile Leu 
    50                  55                  60                  


Pro Gly Ala Leu Arg Leu Ile Gln Glu Leu Arg Pro His Trp Lys Pro 
65                  70                  75                  80  


Glu Gln Val Arg Thr Lys Arg Phe Thr Asp Gly Ile Thr Asn Lys Leu 
                85                  90                  95      


Val Ala Cys Tyr Val Glu Glu Asp Met Gln Asp Cys Val Leu Val Arg 
            100                 105                 110         


Val Tyr Gly Glu Arg Thr Glu Leu Leu Val Asp Arg Glu Asn Glu Val 
        115                 120                 125             


Arg Asn Phe Gln Leu Leu Arg Ala His Ser Cys Ala Pro Lys Leu Tyr 
    130                 135                 140                 


Cys Thr Phe Gln Asn Gly Leu Cys Tyr Glu Tyr Met Gln Gly Val Ala 
145                 150                 155                 160 


Leu Glu Pro Glu His Ile Arg Glu Pro Arg Leu Phe Arg Leu Ile Ala 
                165                 170                 175     


Leu Glu Met Ala Lys Ile His Thr Ile His Ala Asn Gly Ser Leu Pro 
            180                 185                 190         


Lys Pro Ile Leu Trp His Lys Met His Asn Tyr Phe Thr Leu Val Lys 
        195                 200                 205             


Asn Glu Ile Asn Pro Ser Leu Ser Ala Asp Val Pro Lys Val Glu Val 
    210                 215                 220                 


Leu Glu Arg Glu Leu Ala Trp Leu Lys Glu His Leu Ser Gln Leu Glu 
225                 230                 235                 240 


Ser Pro Val Val Phe Cys His Asn Asp Leu Leu Cys Lys Asn Ile Ile 
                245                 250                 255     


Tyr Asp Ser Ile Lys Gly His Val Arg Phe Ile Asp Tyr Glu Tyr Ala 
            260                 265                 270         


Gly Tyr Asn Tyr Gln Ala Phe Asp Ile Gly Asn His Phe Asn Glu Phe 
        275                 280                 285             


Ala Gly Val Asn Glu Val Asp Tyr Cys Leu Tyr Pro Ala Arg Glu Thr 
    290                 295                 300                 


Gln Leu Gln Trp Leu His Tyr Tyr Leu Gln Ala Gln Lys Gly Met Ala 
305                 310                 315                 320 


Val Thr Pro Arg Glu Val Gln Arg Leu Tyr Val Gln Val Asn Lys Phe 
                325                 330                 335     


Ala Leu Gly Pro Ser Cys Val Ser Ser Thr Met Thr Ala Ser Leu Gln 
            340                 345                 350         


Cys Cys Arg Val Gly Asn Arg His Gly Glu Ile Ala Arg Leu Thr Leu 
        355                 360                 365             


Ser Gly Leu Phe Pro Gly Val Ser Leu Leu Leu Gly Ser Leu Gly Pro 
    370                 375                 380                 


His Pro Glu Pro Val Leu His His Arg Leu 
385                 390                 


<210>  3692
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETNPPL__Homo_sapiens__NP_001140062

<400>  3692

Met Cys Glu Leu Tyr Ser Lys Arg Asp Thr Leu Gly Leu Arg Lys Lys 
1               5                   10                  15      


His Ile Gly Pro Ser Cys Lys Val Phe Phe Ala Ser Asp Pro Ile Lys 
            20                  25                  30          


Ile Val Arg Ala Gln Arg Gln Tyr Met Phe Asp Glu Asn Gly Glu Gln 
        35                  40                  45              


Tyr Leu Asp Cys Ile Asn Asn Val Ala His Gly Val Val Lys Ala Ala 
    50                  55                  60                  


Leu Lys Gln Met Glu Leu Leu Asn Thr Asn Ser Arg Phe Leu His Asp 
65                  70                  75                  80  


Asn Ile Val Glu Tyr Ala Lys Arg Leu Ser Ala Thr Leu Pro Glu Lys 
                85                  90                  95      


Leu Ser Val Cys Tyr Phe Thr Asn Ser Gly Ser Glu Ala Asn Asp Leu 
            100                 105                 110         


Ala Leu Arg Leu Ala Arg Gln Phe Arg Gly His Gln Asp Val Ile Thr 
        115                 120                 125             


Leu Asp His Ala Tyr His Gly His Leu Ser Ser Leu Ile Glu Ile Ser 
    130                 135                 140                 


Pro Tyr Lys Phe Gln Lys Gly Lys Asp Val Lys Lys Glu Phe Val His 
145                 150                 155                 160 


Val Ala Pro Thr Pro Asp Thr Tyr Arg Gly Lys Tyr Arg Glu Asp His 
                165                 170                 175     


Ala Asp Ser Ala Ser Ala Tyr Ala Asp Glu Val Lys Lys Ile Ile Glu 
            180                 185                 190         


Asp Ala His Asn Ser Gly Arg Lys Ile Ala Ala Phe Ile Ala Glu Ser 
        195                 200                 205             


Met Gln Ser Cys Gly Gly Gln Ile Ile Pro Pro Ala Gly Tyr Phe Gln 
    210                 215                 220                 


Lys Val Ala Glu Tyr Val His Gly Ala Gly Gly Val Phe Ile Ala Asp 
225                 230                 235                 240 


Glu Val Gln Val Gly Phe Gly Arg Val Gly Lys His Phe Trp Ser Phe 
                245                 250                 255     


Gln Met Tyr Gly Glu Asp Phe Val Pro Asp Ile Val Thr Met Gly Lys 
            260                 265                 270         


Pro Met Gly Asn Gly His Pro Val Ala Cys Val Val Thr Thr Lys Glu 
        275                 280                 285             


Ile Ala Glu Ala Phe Ser Ser Ser Gly Met Glu Tyr Phe Asn Thr Tyr 
    290                 295                 300                 


Gly Gly Asn Pro Val Ser Cys Ala Val Gly Leu Ala Val Leu Asp Ile 
305                 310                 315                 320 


Ile Glu Asn Glu Asp Leu Gln Gly Asn Ala Lys Arg Val Gly Asn Tyr 
                325                 330                 335     


Leu Thr Glu Leu Leu Lys Lys Gln Lys Ala Lys His Thr Leu Ile Gly 
            340                 345                 350         


Asp Ile Arg Gly Ile Gly Leu Phe Ile Gly Ile Asp Leu Val Lys Asp 
        355                 360                 365             


His Leu Lys Arg Thr Pro Ala Thr Ala Glu Ala Gln His Ile Ile Tyr 
    370                 375                 380                 


Lys Met Lys Glu Lys Arg Val Leu Leu Ser Ala Asp Gly Pro His Arg 
385                 390                 395                 400 


Asn Val Leu Lys Ile Lys Pro Pro Met Cys Phe Thr Glu Glu Asp Ala 
                405                 410                 415     


Lys Phe Met Val Asp Gln Leu Asp Arg Ile Leu Thr Val Leu Glu Glu 
            420                 425                 430         


Ala Met Gly Thr Lys Thr Glu Ser Val Thr Ser Glu Asn Thr Pro Cys 
        435                 440                 445             


Lys Thr Lys Met Leu Lys Glu Ala His Ile Glu Leu Leu Arg Asp Ser 
    450                 455                 460                 


Thr Thr Asp Ser Lys Glu Asn Pro Ser Arg Lys Arg Asn Gly Met Cys 
465                 470                 475                 480 


Thr Asp Thr His Ser Leu Leu Ser Lys Arg Leu Lys Thr 
                485                 490             


<210>  3693
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETS1__Homo_sapiens__NP_001137292

<400>  3693

Met Ser Tyr Phe Val Asp Ser Ala Gly Ser Ser Pro Val Pro Tyr Ser 
1               5                   10                  15      


Ala Pro Arg Pro Ala Val Val Arg Gln Gly Pro Ser Asn Thr Tyr Glu 
            20                  25                  30          


Asp Pro Arg Met Asn Cys Gly Phe Gln Ser Asn Tyr His Gln Gln Arg 
        35                  40                  45              


Pro Cys Tyr Pro Phe Trp Asp Glu Met Ala Thr Gln Glu Val Pro Thr 
    50                  55                  60                  


Gly Leu Glu His Cys Val Ser Asp Met Glu Cys Ala Asp Val Pro Leu 
65                  70                  75                  80  


Leu Thr Pro Ser Ser Lys Glu Met Met Ser Gln Ala Leu Lys Ala Thr 
                85                  90                  95      


Phe Ser Gly Phe Thr Lys Glu Gln Gln Arg Leu Gly Ile Pro Lys Asp 
            100                 105                 110         


Pro Arg Gln Trp Thr Glu Thr His Val Arg Asp Trp Val Met Trp Ala 
        115                 120                 125             


Val Asn Glu Phe Ser Leu Lys Gly Val Asp Phe Gln Lys Phe Cys Met 
    130                 135                 140                 


Asn Gly Ala Ala Leu Cys Ala Leu Gly Lys Asp Cys Phe Leu Glu Leu 
145                 150                 155                 160 


Ala Pro Asp Phe Val Gly Asp Ile Leu Trp Glu His Leu Glu Ile Leu 
                165                 170                 175     


Gln Lys Glu Asp Val Lys Pro Tyr Gln Val Asn Gly Val Asn Pro Ala 
            180                 185                 190         


Tyr Pro Glu Ser Arg Tyr Thr Ser Asp Tyr Phe Ile Ser Tyr Gly Ile 
        195                 200                 205             


Glu His Ala Gln Cys Val Pro Pro Ser Glu Phe Ser Glu Pro Ser Phe 
    210                 215                 220                 


Ile Thr Glu Ser Tyr Gln Thr Leu His Pro Ile Ser Ser Glu Glu Leu 
225                 230                 235                 240 


Leu Ser Leu Lys Tyr Glu Asn Asp Tyr Pro Ser Val Ile Leu Arg Asp 
                245                 250                 255     


Pro Leu Gln Thr Asp Thr Leu Gln Asn Asp Tyr Phe Ala Ile Lys Gln 
            260                 265                 270         


Glu Val Val Thr Pro Asp Asn Met Cys Met Gly Arg Thr Ser Arg Gly 
        275                 280                 285             


Lys Leu Gly Gly Gln Asp Ser Phe Glu Ser Ile Glu Ser Tyr Asp Ser 
    290                 295                 300                 


Cys Asp Arg Leu Thr Gln Ser Trp Ser Ser Gln Ser Ser Phe Asn Ser 
305                 310                 315                 320 


Leu Gln Arg Val Pro Ser Tyr Asp Ser Phe Asp Ser Glu Asp Tyr Pro 
                325                 330                 335     


Ala Ala Leu Pro Asn His Lys Pro Lys Gly Thr Phe Lys Asp Tyr Val 
            340                 345                 350         


Arg Asp Arg Ala Asp Leu Asn Lys Asp Lys Pro Val Ile Pro Ala Ala 
        355                 360                 365             


Ala Leu Ala Gly Tyr Thr Gly Ser Gly Pro Ile Gln Leu Trp Gln Phe 
    370                 375                 380                 


Leu Leu Glu Leu Leu Thr Asp Lys Ser Cys Gln Ser Phe Ile Ser Trp 
385                 390                 395                 400 


Thr Gly Asp Gly Trp Glu Phe Lys Leu Ser Asp Pro Asp Glu Val Ala 
                405                 410                 415     


Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met Asn Tyr Glu Lys 
            420                 425                 430         


Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile His Lys 
        435                 440                 445             


Thr Ala Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys Asp Leu Gln Ser 
    450                 455                 460                 


Leu Leu Gly Tyr Thr Pro Glu Glu Leu His Ala Met Leu Asp Val Lys 
465                 470                 475                 480 


Pro Asp Ala Asp Glu 
                485 


<210>  3694
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETS2__Homo_sapiens__NP_001243224

<400>  3694

Met Gly Ser Ala Gln Phe Gln Gly Leu Ile Thr Gln Ala Arg Leu Pro 
1               5                   10                  15      


Phe Gly Ala Thr Ser Thr Thr Ala Pro Ser Leu Arg Asn Ser Lys Gly 
            20                  25                  30          


Arg Phe Gly Val Arg Ala Leu Ala Pro Glu Arg Thr Pro Ser Ala Pro 
        35                  40                  45              


Arg Lys Val Ser Ala Arg Leu Pro Gly Arg Thr Leu Ala Arg Thr Trp 
    50                  55                  60                  


Gly Arg Gly Pro Ala Pro Gly Ala Ser Gly Pro Ala Gly Glu Gly Pro 
65                  70                  75                  80  


Ser Arg Val Thr Ala Gly Gly Gly Gly Lys Leu Arg Ala Pro Gly Ala 
                85                  90                  95      


Ala Arg Pro Ala Ser Gly Leu Pro Asp Arg Leu Trp Pro Ala Pro Ser 
            100                 105                 110         


Pro Ser Pro Gly Ala His Arg Ala Ala Ala Gly Ala Glu Gln Pro Pro 
        115                 120                 125             


Ser Arg Pro Ser Ala Gly Pro Ala Arg Ser Gly Arg Met Asn Asp Phe 
    130                 135                 140                 


Gly Ile Lys Asn Met Asp Gln Val Ala Pro Val Ala Asn Ser Tyr Arg 
145                 150                 155                 160 


Gly Thr Leu Lys Arg Gln Pro Ala Phe Asp Thr Phe Asp Gly Ser Leu 
                165                 170                 175     


Phe Ala Val Phe Pro Ser Leu Asn Glu Glu Gln Thr Leu Gln Glu Val 
            180                 185                 190         


Pro Thr Gly Leu Asp Ser Ile Ser His Asp Ser Ala Asn Cys Glu Leu 
        195                 200                 205             


Pro Leu Leu Thr Pro Cys Ser Lys Ala Val Met Ser Gln Ala Leu Lys 
    210                 215                 220                 


Ala Thr Phe Ser Gly Phe Lys Lys Glu Gln Arg Arg Leu Gly Ile Pro 
225                 230                 235                 240 


Lys Asn Pro Trp Leu Trp Ser Glu Gln Gln Val Cys Gln Trp Leu Leu 
                245                 250                 255     


Trp Ala Thr Asn Glu Phe Ser Leu Val Asn Val Asn Leu Gln Arg Phe 
            260                 265                 270         


Gly Met Asn Gly Gln Met Leu Cys Asn Leu Gly Lys Glu Arg Phe Leu 
        275                 280                 285             


Glu Leu Ala Pro Asp Phe Val Gly Asp Ile Leu Trp Glu His Leu Glu 
    290                 295                 300                 


Gln Met Ile Lys Glu Asn Gln Glu Lys Thr Glu Asp Gln Tyr Glu Glu 
305                 310                 315                 320 


Asn Ser His Leu Thr Ser Val Pro His Trp Ile Asn Ser Asn Thr Leu 
                325                 330                 335     


Gly Phe Gly Thr Glu Gln Ala Pro Tyr Gly Met Gln Thr Gln Asn Tyr 
            340                 345                 350         


Pro Lys Gly Gly Leu Leu Asp Ser Met Cys Pro Ala Ser Thr Pro Ser 
        355                 360                 365             


Val Leu Ser Ser Glu Gln Glu Phe Gln Met Phe Pro Lys Ser Arg Leu 
    370                 375                 380                 


Ser Ser Val Ser Val Thr Tyr Cys Ser Val Ser Gln Asp Phe Pro Gly 
385                 390                 395                 400 


Ser Asn Leu Asn Leu Leu Thr Asn Asn Ser Gly Thr Pro Lys Asp His 
                405                 410                 415     


Asp Ser Pro Glu Asn Gly Ala Asp Ser Phe Glu Ser Ser Asp Ser Leu 
            420                 425                 430         


Leu Gln Ser Trp Asn Ser Gln Ser Ser Leu Leu Asp Val Gln Arg Val 
        435                 440                 445             


Pro Ser Phe Glu Ser Phe Glu Asp Asp Cys Ser Gln Ser Leu Cys Leu 
    450                 455                 460                 


Asn Lys Pro Thr Met Ser Phe Lys Asp Tyr Ile Gln Glu Arg Ser Asp 
465                 470                 475                 480 


Pro Val Glu Gln Gly Lys Pro Val Ile Pro Ala Ala Val Leu Ala Gly 
                485                 490                 495     


Phe Thr Gly Ser Gly Pro Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu 
            500                 505                 510         


Leu Ser Asp Lys Ser Cys Gln Ser Phe Ile Ser Trp Thr Gly Asp Gly 
        515                 520                 525             


Trp Glu Phe Lys Leu Ala Asp Pro Asp Glu Val Ala Arg Arg Trp Gly 
    530                 535                 540                 


Lys Arg Lys Asn Lys Pro Lys Met Asn Tyr Glu Lys Leu Ser Arg Gly 
545                 550                 555                 560 


Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile His Lys Thr Ser Gly Lys 
                565                 570                 575     


Arg Tyr Val Tyr Arg Phe Val Cys Asp Leu Gln Asn Leu Leu Gly Phe 
            580                 585                 590         


Thr Pro Glu Glu Leu His Ala Ile Leu Gly Val Gln Pro Asp Thr Glu 
        595                 600                 605             


Asp 
    


<210>  3695
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETV1__Homo_sapiens__NP_001156619

<400>  3695

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Tyr Met Val Thr Asn Ser 
1               5                   10                  15      


Gln Arg Gly Arg Asn Cys Asn Glu Lys Pro Thr Asn Val Arg Lys Arg 
            20                  25                  30          


Lys Phe Ile Asn Arg Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Thr Trp Leu Ala Glu Ala Gln Val Pro 
    50                  55                  60                  


Asp Asn Asp Glu Gln Phe Val Pro Asp Tyr Gln Ala Glu Ser Leu Ala 
65                  70                  75                  80  


Phe His Gly Leu Pro Leu Lys Ile Lys Lys Glu Pro His Ser Pro Cys 
                85                  90                  95      


Ser Glu Ile Ser Ser Ala Cys Ser Gln Glu Gln Pro Phe Lys Phe Ser 
            100                 105                 110         


Tyr Gly Glu Lys Cys Leu Tyr Asn Val Ser Ala Tyr Asp Gln Lys Pro 
        115                 120                 125             


Gln Val Gly Met Arg Pro Ser Asn Pro Pro Thr Pro Ser Ser Thr Pro 
    130                 135                 140                 


Val Ser Pro Leu His His Ala Ser Pro Asn Ser Thr His Thr Pro Lys 
145                 150                 155                 160 


Pro Asp Arg Ala Phe Pro Ala His Leu Pro Pro Ser Gln Ser Ile Pro 
                165                 170                 175     


Asp Ser Ser Tyr Pro Met Asp His Arg Phe Arg Arg Gln Leu Ser Glu 
            180                 185                 190         


Pro Cys Asn Ser Phe Pro Pro Leu Pro Thr Met Pro Arg Glu Gly Arg 
        195                 200                 205             


Pro Met Tyr Gln Arg Gln Met Ser Glu Pro Asn Ile Pro Phe Pro Pro 
    210                 215                 220                 


Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Val Tyr Glu His Asn Thr 
225                 230                 235                 240 


Met Val Gly Ser Ala Ala Ser Gln Ser Phe Pro Pro Pro Leu Met Ile 
                245                 250                 255     


Lys Gln Glu Pro Arg Asp Phe Ala Tyr Asp Ser Gly Cys Met Phe Glu 
            260                 265                 270         


Lys Gly Pro Arg Gln Phe Tyr Asp Asp Thr Cys Val Val Pro Glu Lys 
        275                 280                 285             


Phe Asp Gly Asp Ile Lys Gln Glu Pro Gly Met Tyr Arg Glu Gly Pro 
    290                 295                 300                 


Thr Tyr Gln Arg Arg Gly Ser Leu Gln Leu Trp Gln Phe Leu Val Ala 
305                 310                 315                 320 


Leu Leu Asp Asp Pro Ser Asn Ser His Phe Ile Ala Trp Thr Gly Arg 
                325                 330                 335     


Gly Met Glu Phe Lys Leu Ile Glu Pro Glu Glu Val Ala Arg Arg Trp 
            340                 345                 350         


Gly Ile Gln Lys Asn Arg Pro Ala Met Asn Tyr Asp Lys Leu Ser Arg 
        355                 360                 365             


Ser Leu Arg Tyr Tyr Tyr Glu Lys Gly Ile Met Gln Lys Val Ala Gly 
    370                 375                 380                 


Glu Arg Tyr Val Tyr Lys Phe Val Cys Asp Pro Glu Ala Leu Phe Ser 
385                 390                 395                 400 


Met Ala Phe Pro Asp Asn Gln Arg Pro Leu Leu Lys Thr Asp Met Glu 
                405                 410                 415     


Arg His Ile Asn Glu Glu Asp Thr Val Pro Leu Ser His Phe Asp Glu 
            420                 425                 430         


Ser Met Ala Tyr Met Pro Glu Gly Gly Cys Cys Asn Pro His Pro Tyr 
        435                 440                 445             


Asn Glu Gly Tyr Val Tyr 
    450                 


<210>  3696
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETV3__Homo_sapiens__NP_005231

<400>  3696

Met Lys Ala Gly Cys Ser Ile Val Glu Lys Pro Glu Gly Gly Gly Gly 
1               5                   10                  15      


Tyr Gln Phe Pro Asp Trp Ala Tyr Lys Thr Glu Ser Ser Pro Gly Ser 
            20                  25                  30          


Arg Gln Ile Gln Leu Trp His Phe Ile Leu Glu Leu Leu Gln Lys Glu 
        35                  40                  45              


Glu Phe Arg His Val Ile Ala Trp Gln Gln Gly Glu Tyr Gly Glu Phe 
    50                  55                  60                  


Val Ile Lys Asp Pro Asp Glu Val Ala Arg Leu Trp Gly Arg Arg Lys 
65                  70                  75                  80  


Cys Lys Pro Gln Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr 
                85                  90                  95      


Tyr Tyr Asn Lys Arg Ile Leu His Lys Thr Lys Gly Lys Arg Phe Thr 
            100                 105                 110         


Tyr Lys Phe Asn Phe Asn Lys Leu Val Met Pro Asn Tyr Pro Phe Ile 
        115                 120                 125             


Asn Ile Arg Ser Ser Gly Lys Ile Gln Thr Leu Leu Val Gly Asn 
    130                 135                 140             


<210>  3697
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETV4__Homo_sapiens__NP_001073143

<400>  3697

Met Glu Arg Arg Met Lys Ala Gly Tyr Leu Asp Gln Gln Val Pro Tyr 
1               5                   10                  15      


Thr Phe Ser Ser Lys Ser Pro Gly Asn Gly Ser Leu Arg Glu Ala Leu 
            20                  25                  30          


Ile Gly Pro Leu Gly Lys Leu Met Asp Pro Gly Ser Leu Pro Pro Leu 
        35                  40                  45              


Asp Ser Glu Asp Leu Phe Gln Asp Leu Ser His Phe Gln Glu Thr Trp 
    50                  55                  60                  


Leu Ala Glu Ala Gln Val Pro Asp Ser Asp Glu Gln Phe Val Pro Asp 
65                  70                  75                  80  


Phe His Ser Glu Asn Leu Ala Phe His Ser Pro Thr Thr Arg Ile Lys 
                85                  90                  95      


Lys Glu Pro Gln Ser Pro Arg Thr Asp Pro Ala Leu Ser Cys Ser Arg 
            100                 105                 110         


Lys Pro Pro Leu Pro Tyr His His Gly Glu Gln Cys Leu Tyr Ser Ser 
        115                 120                 125             


Ala Tyr Asp Pro Pro Arg Gln Ile Ala Ile Lys Ser Pro Ala Pro Gly 
    130                 135                 140                 


Ala Leu Gly Gln Ser Pro Leu Gln Pro Phe Pro Arg Ala Glu Gln Arg 
145                 150                 155                 160 


Asn Phe Leu Arg Ser Ser Gly Thr Ser Gln Pro His Pro Gly His Gly 
                165                 170                 175     


Tyr Leu Gly Glu His Ser Ser Val Phe Gln Gln Pro Leu Asp Ile Cys 
            180                 185                 190         


His Ser Phe Thr Ser Gln Gly Gly Gly Arg Glu Pro Leu Pro Ala Pro 
        195                 200                 205             


Tyr Gln His Gln Leu Ser Glu Pro Cys Pro Pro Tyr Pro Gln Gln Ser 
    210                 215                 220                 


Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu Gln Ala Gly Gln Pro 
225                 230                 235                 240 


Ala Val Asp Gln Gly Gly Val Asn Gly His Arg Tyr Pro Gly Ala Gly 
                245                 250                 255     


Val Val Ile Lys Gln Glu Gln Thr Asp Phe Ala Tyr Asp Ser Asp Val 
            260                 265                 270         


Thr Gly Cys Ala Ser Met Tyr Leu His Thr Glu Gly Phe Ser Gly Pro 
        275                 280                 285             


Ser Pro Gly Asp Gly Ala Met Gly Tyr Gly Tyr Glu Lys Pro Leu Arg 
    290                 295                 300                 


Pro Phe Pro Asp Asp Val Cys Val Val Pro Glu Lys Phe Glu Gly Asp 
305                 310                 315                 320 


Ile Lys Gln Glu Gly Val Gly Ala Phe Arg Glu Gly Pro Pro Tyr Gln 
                325                 330                 335     


Arg Arg Gly Ala Leu Gln Leu Trp Gln Phe Leu Val Ala Leu Leu Asp 
            340                 345                 350         


Asp Pro Thr Asn Ala His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu 
        355                 360                 365             


Phe Lys Leu Ile Glu Pro Glu Glu Val Ala Arg Leu Trp Gly Ile Gln 
    370                 375                 380                 


Lys Asn Arg Pro Ala Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg 
385                 390                 395                 400 


Tyr Tyr Tyr Glu Lys Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr 
                405                 410                 415     


Val Tyr Lys Phe Val Cys Glu Pro Glu Ala Leu Phe Ser Leu Ala Phe 
            420                 425                 430         


Pro Asp Asn Gln Arg Pro Ala Leu Lys Ala Glu Phe Asp Arg Pro Val 
        435                 440                 445             


Ser Glu Glu Asp Thr Val Pro Leu Ser His Leu Asp Glu Ser Pro Ala 
    450                 455                 460                 


Tyr Leu Pro Glu Leu Ala Gly Pro Ala Gln Pro Phe Gly Pro Lys Gly 
465                 470                 475                 480 


Gly Tyr Ser Tyr 
                


<210>  3698
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETV5__Homo_sapiens__NP_004445

<400>  3698

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys 
1               5                   10                  15      


Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg 
            20                  25                  30          


Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro 
    50                  55                  60                  


Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu 
65                  70                  75                  80  


His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser 
                85                  90                  95      


Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr 
            100                 105                 110         


Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro 
        115                 120                 125             


Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr 
    130                 135                 140                 


His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser 
145                 150                 155                 160 


Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro 
                165                 170                 175     


Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala 
            180                 185                 190         


Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro 
        195                 200                 205             


Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu 
    210                 215                 220                 


Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg 
225                 230                 235                 240 


Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro 
                245                 250                 255     


Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu 
            260                 265                 270         


His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser 
        275                 280                 285             


Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu 
    290                 295                 300                 


Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser 
305                 310                 315                 320 


Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp 
                325                 330                 335     


Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu 
            340                 345                 350         


Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu 
        355                 360                 365             


Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala 
    370                 375                 380                 


His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu 
385                 390                 395                 400 


Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala 
                405                 410                 415     


Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys 
            420                 425                 430         


Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val 
        435                 440                 445             


Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg 
    450                 455                 460                 


Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr 
465                 470                 475                 480 


Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met 
                485                 490                 495     


Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr 
            500                 505                 510 


<210>  3699
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETV6__Homo_sapiens__NP_001978

<400>  3699

Met Ser Glu Thr Pro Ala Gln Cys Ser Ile Lys Gln Glu Arg Ile Ser 
1               5                   10                  15      


Tyr Thr Pro Pro Glu Ser Pro Val Pro Ser Tyr Ala Ser Ser Thr Pro 
            20                  25                  30          


Leu His Val Pro Val Pro Arg Ala Leu Arg Met Glu Glu Asp Ser Ile 
        35                  40                  45              


Arg Leu Pro Ala His Leu Arg Leu Gln Pro Ile Tyr Trp Ser Arg Asp 
    50                  55                  60                  


Asp Val Ala Gln Trp Leu Lys Trp Ala Glu Asn Glu Phe Ser Leu Arg 
65                  70                  75                  80  


Pro Ile Asp Ser Asn Thr Phe Glu Met Asn Gly Lys Ala Leu Leu Leu 
                85                  90                  95      


Leu Thr Lys Glu Asp Phe Arg Tyr Arg Ser Pro His Ser Gly Asp Val 
            100                 105                 110         


Leu Tyr Glu Leu Leu Gln His Ile Leu Lys Gln Arg Lys Pro Arg Ile 
        115                 120                 125             


Leu Phe Ser Pro Phe Phe His Pro Gly Asn Ser Ile His Thr Gln Pro 
    130                 135                 140                 


Glu Val Ile Leu His Gln Asn His Glu Glu Asp Asn Cys Val Gln Arg 
145                 150                 155                 160 


Thr Pro Arg Pro Ser Val Asp Asn Val His His Asn Pro Pro Thr Ile 
                165                 170                 175     


Glu Leu Leu His Arg Ser Arg Ser Pro Ile Thr Thr Asn His Arg Pro 
            180                 185                 190         


Ser Pro Asp Pro Glu Gln Arg Pro Leu Arg Ser Pro Leu Asp Asn Met 
        195                 200                 205             


Ile Arg Arg Leu Ser Pro Ala Glu Arg Ala Gln Gly Pro Arg Pro His 
    210                 215                 220                 


Gln Glu Asn Asn His Gln Glu Ser Tyr Pro Leu Ser Val Ser Pro Met 
225                 230                 235                 240 


Glu Asn Asn His Cys Pro Ala Ser Ser Glu Ser His Pro Lys Pro Ser 
                245                 250                 255     


Ser Pro Arg Gln Glu Ser Thr Arg Val Ile Gln Leu Met Pro Ser Pro 
            260                 265                 270         


Ile Met His Pro Leu Ile Leu Asn Pro Arg His Ser Val Asp Phe Lys 
        275                 280                 285             


Gln Ser Arg Leu Ser Glu Asp Gly Leu His Arg Glu Gly Lys Pro Ile 
    290                 295                 300                 


Asn Leu Ser His Arg Glu Asp Leu Ala Tyr Met Asn His Ile Met Val 
305                 310                 315                 320 


Ser Val Ser Pro Pro Glu Glu His Ala Met Pro Ile Gly Arg Ile Ala 
                325                 330                 335     


Asp Cys Arg Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Ser Asp Ser 
            340                 345                 350         


Arg Tyr Glu Asn Phe Ile Arg Trp Glu Asp Lys Glu Ser Lys Ile Phe 
        355                 360                 365             


Arg Ile Val Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys 
    370                 375                 380                 


Asn Arg Thr Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His 
385                 390                 395                 400 


Tyr Tyr Lys Leu Asn Ile Ile Arg Lys Glu Pro Gly Gln Arg Leu Leu 
                405                 410                 415     


Phe Arg Phe Met Lys Thr Pro Asp Glu Ile Met Ser Gly Arg Thr Asp 
            420                 425                 430         


Arg Leu Glu His Leu Glu Ser Gln Glu Leu Asp Glu Gln Ile Tyr Gln 
        435                 440                 445             


Glu Asp Glu Cys 
    450         


<210>  3700
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETV7__Homo_sapiens__NP_001193964

<400>  3700

Met Gln Glu Gly Glu Leu Ala Ile Ser Pro Ile Ser Pro Val Ala Ala 
1               5                   10                  15      


Met Pro Pro Leu Gly Thr His Val Gln Ala Arg Cys Glu Ala Gln Ile 
            20                  25                  30          


Asn Leu Leu Gly Glu Gly Gly Ile Cys Lys Leu Pro Gly Arg Leu Arg 
        35                  40                  45              


Ile Gln Pro Ala Leu Trp Ser Arg Glu Asp Val Leu His Trp Leu Arg 
    50                  55                  60                  


Trp Ala Glu Gln Glu Tyr Ser Leu Pro Cys Thr Ala Glu His Gly Phe 
65                  70                  75                  80  


Glu Met Asn Gly Arg Ala Leu Cys Ile Leu Thr Lys Asp Asp Phe Arg 
                85                  90                  95      


His Arg Ala Pro Ser Ser Gly Asp Val Leu Tyr Glu Leu Leu Gln Tyr 
            100                 105                 110         


Ile Lys Thr Gln Arg Arg Ala Leu Val Cys Gly Pro Phe Phe Gly Gly 
        115                 120                 125             


Ile Phe Arg Leu Lys Thr Pro Thr Gln His Ser Pro Val Pro Pro Glu 
    130                 135                 140                 


Glu Val Thr Gly Pro Ser Gln Met Asp Thr Arg Arg Gly His Leu Leu 
145                 150                 155                 160 


Gln Pro Pro Asp Pro Gly Leu Thr Ser Asn Phe Gly His Leu Asp Asp 
                165                 170                 175     


Pro Gly Leu Ala Arg Trp Thr Pro Gly Lys Glu Glu Ser Leu Asn Leu 
            180                 185                 190         


Cys His Cys Ala Glu Leu Gly Cys Arg Thr Gln Gly Val Cys Ser Phe 
        195                 200                 205             


Pro Ala Met Pro Gln Ala Pro Ile Asp Gly Arg Ile Ala Asp Cys Arg 
    210                 215                 220                 


Leu Leu Trp Asp Tyr Val Tyr Gln Leu Leu Leu Asp Thr Arg Tyr Glu 
225                 230                 235                 240 


Pro Tyr Ile Lys Trp Glu Asp Lys Asp Ala Lys Ile Phe Arg Val Val 
                245                 250                 255     


Asp Pro Asn Gly Leu Ala Arg Leu Trp Gly Asn His Lys Asn Arg Val 
            260                 265                 270         


Asn Met Thr Tyr Glu Lys Met Ser Arg Ala Leu Arg His Tyr Tyr Lys 
        275                 280                 285             


Leu Asn Ile Ile Lys Lys Glu Pro Gly Gln Lys Leu Leu Phe Arg Asn 
    290                 295                 300                 


Gly Leu Gln Leu Ile Phe Ile Phe Ile Trp Ser Phe Gln 
305                 310                 315         


<210>  3701
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVA1A__Homo_sapiens__NP_115557

<400>  3701

Met Arg Leu Pro Leu Ser His Ser Pro Glu His Val Glu Met Ala Leu 
1               5                   10                  15      


Leu Ser Asn Ile Leu Ala Ala Tyr Ser Phe Val Ser Glu Asn Pro Glu 
            20                  25                  30          


Arg Ala Ala Leu Tyr Phe Val Ser Gly Val Cys Ile Gly Leu Val Leu 
        35                  40                  45              


Thr Leu Ala Ala Leu Val Ile Arg Ile Ser Cys His Thr Asp Cys Arg 
    50                  55                  60                  


Arg Arg Pro Gly Lys Lys Phe Leu Gln Asp Arg Glu Ser Ser Ser Asp 
65                  70                  75                  80  


Ser Ser Asp Ser Glu Asp Gly Ser Glu Asp Thr Val Ser Asp Leu Ser 
                85                  90                  95      


Val Arg Arg His Arg Arg Phe Glu Arg Thr Leu Asn Lys Asn Val Phe 
            100                 105                 110         


Thr Ser Ala Glu Glu Leu Glu Arg Ala Gln Arg Leu Glu Glu Arg Glu 
        115                 120                 125             


Arg Ile Ile Arg Glu Ile Trp Met Asn Gly Gln Pro Glu Val Pro Gly 
    130                 135                 140                 


Thr Arg Ser Leu Asn Arg Tyr Tyr 
145                 150         


<210>  3702
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVA1C__Homo_sapiens__NP_478067

<400>  3702

Met Leu Leu Pro Gly Arg Ala Arg Gln Pro Pro Thr Pro Gln Pro Val 
1               5                   10                  15      


Gln His Pro Gly Leu Arg Arg Gln Val Glu Pro Pro Gly Gln Leu Leu 
            20                  25                  30          


Arg Leu Phe Tyr Cys Thr Val Leu Val Cys Ser Lys Glu Ile Ser Ala 
        35                  40                  45              


Leu Thr Asp Phe Ser Gly Tyr Leu Thr Lys Leu Leu Gln Asn His Thr 
    50                  55                  60                  


Thr Tyr Ala Cys Asp Gly Asp Tyr Leu Asn Leu Gln Cys Pro Arg His 
65                  70                  75                  80  


Ser Thr Ile Ser Val Gln Ser Ala Phe Tyr Gly Gln Asp Tyr Gln Met 
                85                  90                  95      


Cys Ser Ser Gln Lys Pro Ala Ser Gln Arg Glu Asp Ser Leu Thr Cys 
            100                 105                 110         


Val Ala Ala Thr Thr Phe Gln Lys Val Leu Asp Glu Cys Gln Asn Gln 
        115                 120                 125             


Arg Ala Cys His Leu Leu Val Asn Ser Arg Val Phe Gly Pro Asp Leu 
    130                 135                 140                 


Cys Pro Gly Ser Ser Lys Tyr Leu Leu Val Ser Phe Lys Cys Gln Pro 
145                 150                 155                 160 


Asn Glu Leu Lys Asn Lys Thr Val Cys Glu Asp Gln Glu Leu Lys Leu 
                165                 170                 175     


His Cys His Glu Ser Lys Phe Leu Asn Ile Tyr Ser Ala Thr Tyr Gly 
            180                 185                 190         


Arg Arg Thr Gln Glu Arg Asp Ile Cys Ser Ser Lys Ala Glu Arg Leu 
        195                 200                 205             


Pro Pro Phe Asp Cys Leu Ser Tyr Ser Ala Leu Gln Val Leu Ser Arg 
    210                 215                 220                 


Arg Cys Tyr Gly Lys Gln Arg Cys Lys Ile Ile Val Asn Asn His His 
225                 230                 235                 240 


Phe Gly Ser Pro Cys Leu Pro Gly Val Lys Lys Tyr Leu Thr Val Thr 
                245                 250                 255     


Tyr Ala Cys Val Pro Lys Asn Ile Leu Thr Ala Ile Asp Pro Ala Ile 
            260                 265                 270         


Ala Asn Leu Lys Pro Ser Leu Lys Gln Lys Asp Gly Glu Tyr Gly Ile 
        275                 280                 285             


Asn Phe Asp Pro Ser Gly Ser Lys Val Leu Arg Lys Asp Gly Ile Leu 
    290                 295                 300                 


Val Ser Asn Ser Leu Ala Ala Phe Ala Tyr Ile Arg Ala His Pro Glu 
305                 310                 315                 320 


Arg Ala Ala Leu Leu Phe Val Ser Ser Val Cys Ile Gly Leu Ala Leu 
                325                 330                 335     


Thr Leu Cys Ala Leu Val Ile Arg Glu Ser Cys Ala Lys Asp Phe Arg 
            340                 345                 350         


Asp Leu Gln Leu Gly Arg Glu Gln Leu Val Pro Gly Ser Asp Lys Val 
        355                 360                 365             


Glu Glu Asp Ser Glu Asp Glu Glu Glu Glu Glu Asp Pro Ser Glu Ser 
    370                 375                 380                 


Asp Phe Pro Gly Glu Leu Ser Gly Phe Cys Arg Thr Ser Tyr Pro Ile 
385                 390                 395                 400 


Tyr Ser Ser Ile Glu Ala Ala Glu Leu Ala Glu Arg Ile Glu Arg Arg 
                405                 410                 415     


Glu Gln Ile Ile Gln Glu Ile Trp Met Asn Ser Gly Leu Asp Thr Ser 
            420                 425                 430         


Leu Pro Arg Asn Met Gly Gln Phe Tyr 
        435                 440     


<210>  3703
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVC2__Homo_sapiens__NP_001159608

<400>  3703

Met Ile Trp Pro Lys Val Glu Cys Cys His Phe Lys Thr Ala Val Glu 
1               5                   10                  15      


Ala Pro Leu Gly Met Lys Leu Asp Lys Lys Met Glu Val Phe Ile Pro 
            20                  25                  30          


Leu Ser Thr Ser Ala Ala Ser Ser Gly Pro Trp Ala His Ser Leu Phe 
        35                  40                  45              


Ala Phe Ile Pro Ser Trp Pro Lys Lys Asn Leu Phe Lys Arg Glu Ser 
    50                  55                  60                  


Pro Ile Thr His Arg Leu Tyr Gly Asp Ile Ser Arg Glu Val Gln Gly 
65                  70                  75                  80  


Thr Ser Glu Asn Gly Val Ile Phe Gln Lys Cys Ala Leu Val Ser Gly 
                85                  90                  95      


Ser Ser Glu Ala Gln Thr Ala Arg Ile Trp Leu Leu Val Asn Asn Thr 
            100                 105                 110         


Lys Thr Thr Ser Ser Ala Asn Leu Ser Glu Leu Leu Leu Leu Asp Ser 
        115                 120                 125             


Ile Ala Gly Leu Thr Ile Trp Asp Ser Val Gly Asn Arg Thr Ser Glu 
    130                 135                 140                 


Gly Phe Gln Ala Phe Ser Lys Lys Phe Leu Gln Val Gly Asp Ala Phe 
145                 150                 155                 160 


Ala Val Ser Tyr Ala Ala Thr Leu Gln Ala Gly Asp Leu Gly Asn Gly 
                165                 170                 175     


Glu Ser Leu Lys Leu Pro Ala Gln Leu Thr Phe Gln Ser Ser Ser Arg 
            180                 185                 190         


Asn Arg Thr Gln Leu Lys Val Leu Phe Ser Ile Thr Ala Glu Glu Asn 
        195                 200                 205             


Val Thr Val Leu Pro His His Gly Leu His Ala Ala Gly Phe Phe Ile 
    210                 215                 220                 


Ala Phe Leu Leu Ser Leu Val Leu Thr Trp Ala Ala Leu Phe Leu Met 
225                 230                 235                 240 


Val Arg Tyr Gln Cys Leu Lys Gly Asn Met Leu Thr Arg His Arg Val 
                245                 250                 255     


Trp Gln Tyr Glu Ser Lys Leu Glu Pro Leu Pro Phe Thr Ser Ala Asp 
            260                 265                 270         


Gly Val Asn Glu Asp Leu Ser Leu Asn Asp Gln Met Ile Asp Ile Leu 
        275                 280                 285             


Ser Ser Glu Asp Pro Gly Ser Met Leu Gln Ala Leu Glu Glu Leu Glu 
    290                 295                 300                 


Ile Ala Thr Leu Asn Arg Ala Asp Ala Asp Leu Glu Ala Cys Arg Thr 
305                 310                 315                 320 


Gln Ile Ser Lys Asp Ile Ile Ala Leu Leu Leu Lys Asn Leu Thr Ser 
                325                 330                 335     


Ser Gly His Leu Ser Pro Gln Val Glu Arg Lys Met Ser Ala Val Phe 
            340                 345                 350         


Lys Lys Gln Phe Leu Leu Leu Glu Asn Glu Ile Gln Glu Glu Tyr Asp 
        355                 360                 365             


Arg Lys Met Val Ala Leu Thr Ala Glu Cys Asp Leu Glu Thr Arg Lys 
    370                 375                 380                 


Lys Met Glu Asn Gln Tyr Gln Arg Glu Met Met Ala Met Glu Glu Ala 
385                 390                 395                 400 


Glu Glu Leu Leu Lys Arg Ala Gly Glu Arg Ser Ala Val Glu Cys Ser 
                405                 410                 415     


Asn Leu Leu Arg Thr Leu His Gly Leu Glu Gln Glu His Leu Arg Lys 
            420                 425                 430         


Ser Leu Ala Leu Gln Gln Glu Glu Asp Phe Ala Lys Ala His Arg Gln 
        435                 440                 445             


Leu Ala Val Phe Gln Arg Asn Glu Leu His Ser Ile Phe Phe Thr Gln 
    450                 455                 460                 


Ile Lys Ser Ala Ile Phe Lys Gly Glu Leu Lys Pro Glu Ala Ala Lys 
465                 470                 475                 480 


Met Leu Leu Gln Asn Tyr Ser Lys Ile Gln Glu Asn Val Glu Glu Leu 
                485                 490                 495     


Met Asp Phe Phe Gln Ala Ser Lys Arg Tyr His Leu Ser Lys Arg Phe 
            500                 505                 510         


Gly His Arg Glu Tyr Leu Val Gln Asn Leu Gln Ser Ser Glu Thr Arg 
        515                 520                 525             


Val Gln Gly Leu Leu Ser Thr Ala Ala Ala Gln Leu Thr His Leu Ile 
    530                 535                 540                 


Gln Lys His Glu Arg Ala Gly Tyr Leu Asp Glu Asp Gln Met Glu Met 
545                 550                 555                 560 


Leu Leu Glu Arg Ala Gln Thr Glu Val Phe Ser Ile Lys Gln Lys Leu 
                565                 570                 575     


Asp Asn Asp Leu Lys Gln Glu Lys Lys Lys Leu His Gln Lys Leu Ile 
            580                 585                 590         


Thr Lys Arg Arg Arg Glu Leu Leu Gln Lys His Arg Glu Gln Arg Arg 
        595                 600                 605             


Glu Gln Ala Ser Val Gly Glu Ala Phe Arg Thr Val Glu Asp Ala Gly 
    610                 615                 620                 


Gln Tyr Leu His Gln Lys Arg Ser Leu Met Glu Glu His Gly Ala Thr 
625                 630                 635                 640 


Leu Glu Glu Leu Gln Glu Arg Leu Asp Gln Ala Ala Leu Asp Asp Leu 
                645                 650                 655     


Arg Thr Leu Thr Leu Ser Leu Phe Glu Lys Ala Thr Asp Glu Leu Arg 
            660                 665                 670         


Arg Leu Gln Asn Ser Ala Met Thr Gln Glu Leu Leu Lys Arg Gly Val 
        675                 680                 685             


Pro Trp Leu Phe Leu Gln Gln Ile Leu Glu Glu His Gly Lys Glu Met 
    690                 695                 700                 


Ala Ala Arg Ala Glu Gln Leu Glu Gly Glu Glu Arg Asp Arg Asp Gln 
705                 710                 715                 720 


Glu Gly Val Gln Ser Val Arg Gln Arg Leu Lys Asp Asp Ala Pro Glu 
                725                 730                 735     


Ala Val Thr Glu Glu Gln Ala Glu Leu Arg Arg Trp Glu His Leu Ile 
            740                 745                 750         


Phe Met Lys Leu Cys Ser Ser Val Phe Ser Leu Ser Glu Glu Glu Leu 
        755                 760                 765             


Leu Arg Met Arg Gln Glu Val His Gly Cys Phe Ala Gln Met Asp Arg 
    770                 775                 780                 


Ser Leu Ala Leu Pro Lys Ile Arg Ala Arg Val Leu Leu Gln Gln Phe 
785                 790                 795                 800 


Gln Thr Ala Trp Arg Glu Ala Glu Phe Val Lys Leu Asp Gln Ala Val 
                805                 810                 815     


Ala Ala Pro Glu Leu Gln Gln Gln Ser Lys Val Arg Lys Ser Arg Ser 
            820                 825                 830         


Lys Ser Lys Ser Lys Gly Glu Leu Leu Lys Lys Cys Ile Glu Asp Lys 
        835                 840                 845             


Ile His Leu Cys Glu Glu Gln Ala Ser Glu Asp Leu Val Glu Lys Val 
    850                 855                 860                 


Arg Gly Glu Leu Leu Arg Glu Arg Val Gln Arg Met Glu Ala Gln Glu 
865                 870                 875                 880 


Gly Gly Phe Ala Gln Ser Leu Val Ala Leu Gln Phe Gln Lys Ala Ser 
                885                 890                 895     


Arg Val Thr Glu Thr Leu Ser Ala Tyr Thr Ala Leu Leu Ser Ile Gln 
            900                 905                 910         


Asp Leu Leu Leu Glu Glu Leu Ser Ala Ser Glu Met Leu Thr Lys Ser 
        915                 920                 925             


Ala Cys Thr Gln Ile Leu Glu Ser His Ser Arg Glu Leu Gln Glu Leu 
    930                 935                 940                 


Glu Arg Lys Leu Glu Asp Gln Leu Val Gln Gln Glu Ala Ala Gln Gln 
945                 950                 955                 960 


Gln Gln Ala Leu Ala Ser Trp Gln Gln Trp Val Ala Asp Gly Pro Gly 
                965                 970                 975     


Ile Leu Asn Glu Pro Gly Glu Val Asp Ser Glu Arg Gln Val Ser Thr 
            980                 985                 990         


Val Leu His Gln Ala Leu Ser Lys  Ser Gln Thr Leu Leu  Glu Gln His 
        995                 1000                 1005             


Gln Gln  Cys Leu Arg Glu Glu  Gln Gln Asn Ser Val  Val Leu Glu 
    1010                 1015                 1020             


Asp Leu  Leu Glu Asn Met Glu  Ala Asp Thr Phe Ala  Thr Leu Cys 
    1025                 1030                 1035             


Ser Gln  Glu Leu Arg Leu Ala  Ser Tyr Leu Ala Arg  Met Ala Met 
    1040                 1045                 1050             


Val Pro  Gly Ala Thr Leu Arg  Arg Leu Leu Ser Val  Val Leu Pro 
    1055                 1060                 1065             


Thr Ala  Ser Gln Pro Gln Leu  Leu Ala Leu Leu Asp  Ser Ala Thr 
    1070                 1075                 1080             


Glu Arg  His Val Asp His Ala  Ala Glu Ser Asp Gly  Gly Ala Glu 
    1085                 1090                 1095             


Gln Ala  Asp Val Gly Arg Arg  Arg Lys His Gln Ser  Trp Trp Gln 
    1100                 1105                 1110             


Ala Leu  Asp Gly Lys Leu Arg  Gly Asp Leu Ile Ser  Arg Gly Leu 
    1115                 1120                 1125             


Glu Lys  Met Leu Trp Ala Arg  Lys Arg Lys Gln Ser  Ile Leu Lys 
    1130                 1135                 1140             


Lys Thr  Cys Leu Pro Leu Arg  Glu Arg Met Ile Phe  Ser Gly Lys 
    1145                 1150                 1155             


Gly Ser  Trp Pro His Leu Ser  Leu Glu Pro Ile Gly  Glu Leu Ala 
    1160                 1165                 1170             


Pro Val  Pro Ile Val Gly Ala  Glu Thr Ile Asp Leu  Leu Asn Thr 
    1175                 1180                 1185             


Gly Glu  Lys Leu Phe Ile Phe  Arg Asn Pro Lys Glu  Pro Glu Ile 
    1190                 1195                 1200             


Ser Leu  His Val Pro Pro Arg  Lys Lys Lys Asn Phe  Leu Asn Ala 
    1205                 1210                 1215             


Lys Lys  Ala Met Arg Ala Leu  Gly Met Asp 
    1220                 1225             


<210>  3704
<211>  992
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVC__Homo_sapiens__NP_714928

<400>  3704

Met Ala Arg Gly Gly Ala Ala Cys Lys Ser Asp Ala Arg Leu Leu Leu 
1               5                   10                  15      


Gly Arg Asp Ala Leu Arg Pro Ala Pro Ala Leu Leu Ala Pro Ala Val 
            20                  25                  30          


Leu Leu Gly Ala Ala Leu Gly Leu Gly Leu Gly Leu Trp Leu Gly Cys 
        35                  40                  45              


Arg Ala Gly Arg Gln Arg Thr Arg His Gln Lys Asp Asp Thr Gln Asn 
    50                  55                  60                  


Leu Leu Lys Asn Leu Glu Ser Asn Ala Gln Thr Pro Ser Glu Thr Gly 
65                  70                  75                  80  


Ser Pro Ser Arg Arg Arg Lys Arg Glu Val Gln Met Ser Lys Asp Lys 
                85                  90                  95      


Glu Ala Val Asp Glu Cys Glu Pro Pro Ser Asn Ser Asn Ile Thr Ala 
            100                 105                 110         


Phe Ala Leu Lys Ala Lys Val Ile Tyr Pro Ile Asn Gln Lys Phe Arg 
        115                 120                 125             


Pro Leu Ala Asp Gly Ser Ser Asn Pro Ser Leu His Glu Asn Leu Lys 
    130                 135                 140                 


Gln Ala Val Leu Pro His Gln Pro Val Glu Ala Ser Pro Ser Ser Ser 
145                 150                 155                 160 


Leu Gly Ser Leu Ser Gln Gly Glu Lys Asp Asp Cys Ser Ser Ser Ser 
                165                 170                 175     


Ser Val His Ser Ala Thr Ser Asp Asp Arg Phe Leu Ser Arg Thr Phe 
            180                 185                 190         


Leu Arg Val Asn Ala Phe Pro Glu Val Leu Ala Cys Glu Ser Val Asp 
        195                 200                 205             


Val Asp Leu Cys Ile Tyr Ser Leu His Leu Lys Asp Leu Leu His Leu 
    210                 215                 220                 


Asp Thr Ala Leu Arg Gln Glu Lys His Met Met Phe Ile Gln Ile Phe 
225                 230                 235                 240 


Lys Met Cys Leu Leu Asp Leu Leu Pro Lys Lys Lys Ser Asp Asp Glu 
                245                 250                 255     


Leu Tyr Gln Lys Ile Leu Ser Lys Gln Glu Lys Asp Leu Glu Glu Leu 
            260                 265                 270         


Glu Lys Gly Leu Gln Val Lys Leu Ser Asn Thr Glu Met Ser Gly Ala 
        275                 280                 285             


Gly Asp Ser Glu Tyr Ile Thr Leu Ala Asp Val Glu Lys Lys Glu Arg 
    290                 295                 300                 


Glu Tyr Ser Glu Gln Leu Ile Asp Asn Met Glu Ala Phe Trp Lys Gln 
305                 310                 315                 320 


Met Ala Asn Ile Gln His Phe Leu Val Asp Gln Phe Lys Cys Ser Ser 
                325                 330                 335     


Ser Lys Ala Arg Gln Leu Met Met Thr Leu Thr Glu Arg Met Ile Ala 
            340                 345                 350         


Ala Glu Gly Leu Leu Cys Asp Ser Gln Glu Leu Gln Ala Leu Asp Ala 
        355                 360                 365             


Leu Glu Arg Thr Met Gly Arg Ala His Met Ala Lys Val Ile Glu Phe 
    370                 375                 380                 


Leu Lys Leu Gln Val Gln Glu Glu Thr Arg Cys Arg Leu Ala Ala Ile 
385                 390                 395                 400 


Ser His Gly Leu Glu Leu Leu Ala Gly Glu Gly Lys Leu Ser Gly Arg 
                405                 410                 415     


Gln Lys Glu Glu Leu Leu Thr Gln Gln His Lys Ala Phe Trp Gln Glu 
            420                 425                 430         


Ala Glu Arg Phe Ser Arg Glu Phe Val Gln Arg Gly Lys Asp Leu Val 
        435                 440                 445             


Thr Ala Ser Leu Ala His Gln Val Glu Gly Thr Ala Lys Leu Thr Leu 
    450                 455                 460                 


Ala Gln Glu Glu Glu Gln Arg Ser Phe Leu Ala Glu Ala Gln Pro Thr 
465                 470                 475                 480 


Ala Asp Pro Glu Lys Phe Leu Glu Ala Phe His Glu Val Leu Glu Arg 
                485                 490                 495     


Gln Arg Leu Met Gln Cys Asp Leu Glu Glu Glu Glu Asn Val Arg Ala 
            500                 505                 510         


Thr Glu Ala Val Val Ala Leu Cys Gln Glu Leu Tyr Phe Ser Thr Val 
        515                 520                 525             


Asp Thr Phe Gln Lys Phe Val Asp Ala Leu Phe Leu Gln Thr Leu Pro 
    530                 535                 540                 


Gly Met Thr Gly Leu Pro Pro Glu Glu Cys Asp Tyr Leu Arg Gln Glu 
545                 550                 555                 560 


Val Gln Glu Asn Ala Ala Trp Gln Leu Gly Lys Ser Asn Arg Phe Arg 
                565                 570                 575     


Arg Gln Gln Trp Lys Leu Phe Gln Glu Leu Leu Glu Gln Asp Gln Gln 
            580                 585                 590         


Val Trp Met Glu Glu Cys Ala Leu Ser Ser Val Leu Gln Thr His Leu 
        595                 600                 605             


Arg Glu Asp His Glu Gly Thr Ile Arg Gly Val Leu Gly Arg Leu Gly 
    610                 615                 620                 


Gly Leu Thr Glu Glu Ser Thr Arg Cys Val Leu Gln Gly His Asp Leu 
625                 630                 635                 640 


Leu Leu Arg Ser Ala Leu Arg Arg Leu Ala Leu Arg Gly Asn Ala Leu 
                645                 650                 655     


Ala Thr Leu Thr Gln Met Arg Leu Ser Gly Lys Lys His Leu Leu Gln 
            660                 665                 670         


Glu Leu Arg Glu Gln Arg Ala Leu Glu Gln Gly Ser Ser Gln Cys Leu 
        675                 680                 685             


Asp Glu His Gln Trp Gln Leu Leu Arg Ala Leu Glu Ala Arg Val Leu 
    690                 695                 700                 


Glu Glu Ala Ser Arg Leu Glu Glu Glu Ala Gln Gln Thr Arg Leu Gln 
705                 710                 715                 720 


Leu Gln Gln Arg Leu Leu Ala Glu Ala Gln Glu Val Gly Gln Leu Leu 
                725                 730                 735     


Gln Gln His Met Glu Cys Ala Ile Gly Gln Ala Leu Leu Val His Ala 
            740                 745                 750         


Arg Asn Ala Ala Thr Lys Ser Arg Ala Lys Asp Arg Asp Asp Phe Lys 
        755                 760                 765             


Arg Thr Leu Met Glu Ala Ala Val Glu Ser Val Tyr Val Thr Ser Ala 
    770                 775                 780                 


Gly Val Ser Arg Leu Val Gln Ala Tyr Tyr Gln Gln Ile Gly Arg Ile 
785                 790                 795                 800 


Met Glu Asp His Glu Glu Arg Lys Leu Gln His Leu Lys Thr Leu Gln 
                805                 810                 815     


Gly Glu Arg Met Glu Asn Tyr Lys Leu Arg Lys Lys Gln Glu Leu Ser 
            820                 825                 830         


Asn Pro Ser Ser Gly Ser Arg Thr Ala Gly Gly Ala His Glu Thr Ser 
        835                 840                 845             


Gln Ala Val His Gln Arg Met Leu Ser Gln Gln Lys Arg Phe Leu Ala 
    850                 855                 860                 


Gln Phe Pro Val His Gln Gln Met Arg Leu His Ala Gln Gln Gln Gln 
865                 870                 875                 880 


Ala Gly Val Met Asp Leu Leu Glu Ala Gln Leu Glu Thr Gln Leu Gln 
                885                 890                 895     


Glu Ala Glu Gln Asn Phe Ile Ser Glu Leu Ala Ala Leu Ala Arg Val 
            900                 905                 910         


Pro Leu Ala Glu Ser Lys Leu Leu Pro Ala Lys Arg Gly Leu Leu Glu 
        915                 920                 925             


Lys Pro Leu Arg Thr Lys Arg Lys Lys Pro Leu Pro Gln Glu Arg Gly 
    930                 935                 940                 


Asp Leu Gly Val Pro Asn Asn Glu Asp Leu Ala Ser Gly Asp Gln Thr 
945                 950                 955                 960 


Ser Gly Ser Leu Ser Ser Lys Arg Leu Ser Gln Gln Glu Ser Glu Ala 
                965                 970                 975     


Gly Asp Ser Gly Asn Ser Lys Lys Met Leu Lys Arg Arg Ser Asn Leu 
            980                 985                 990         


<210>  3705
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVI2A__Homo_sapiens__NP_001003927

<400>  3705

Met Leu Leu Arg Ser Trp Phe Gly Asn Lys Asp Phe Gln Ala Leu Pro 
1               5                   10                  15      


Ile Leu Ala Arg Leu Pro Ser Met Pro Thr Asp Met Glu His Thr Gly 
            20                  25                  30          


His Tyr Leu His Leu Ala Phe Leu Met Thr Thr Val Phe Ser Leu Ser 
        35                  40                  45              


Pro Gly Thr Lys Ala Asn Tyr Thr Arg Leu Trp Ala Asn Ser Thr Ser 
    50                  55                  60                  


Ser Trp Asp Ser Val Ile Gln Asn Lys Thr Gly Arg Asn Gln Asn Glu 
65                  70                  75                  80  


Asn Ile Asn Thr Asn Pro Ile Thr Pro Glu Val Asp Tyr Lys Gly Asn 
                85                  90                  95      


Ser Thr Asn Met Pro Glu Thr Ser His Ile Val Ala Leu Thr Ser Lys 
            100                 105                 110         


Ser Glu Gln Glu Leu Tyr Ile Pro Ser Val Val Ser Asn Ser Pro Ser 
        115                 120                 125             


Thr Val Gln Ser Ile Glu Asn Thr Ser Lys Ser His Gly Glu Ile Phe 
    130                 135                 140                 


Lys Lys Asp Val Cys Ala Glu Asn Asn Asn Asn Met Ala Met Leu Ile 
145                 150                 155                 160 


Cys Leu Ile Ile Ile Ala Val Leu Phe Leu Ile Cys Thr Phe Leu Phe 
                165                 170                 175     


Leu Ser Thr Val Val Leu Ala Asn Lys Val Ser Ser Leu Arg Arg Ser 
            180                 185                 190         


Lys Gln Val Gly Lys Arg Gln Pro Arg Ser Asn Gly Asp Phe Leu Ala 
        195                 200                 205             


Ser Gly Leu Trp Pro Ala Glu Ser Asp Thr Trp Lys Arg Thr Lys Gln 
    210                 215                 220                 


Leu Thr Gly Pro Asn Leu Val Met Gln Ser Thr Gly Val Leu Thr Ala 
225                 230                 235                 240 


Thr Arg Glu Arg Lys Asp Glu Glu Gly Thr Glu Lys Leu Thr Asn Lys 
                245                 250                 255     


Gln Ile Gly 
            


<210>  3706
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVI2B__Homo_sapiens__NP_006486

<400>  3706

Met Asp Pro Lys Tyr Phe Ile Leu Ile Leu Phe Cys Gly His Leu Asn 
1               5                   10                  15      


Asn Thr Phe Phe Ser Lys Thr Glu Thr Ile Thr Thr Glu Lys Gln Ser 
            20                  25                  30          


Gln Pro Thr Leu Phe Thr Ser Ser Met Ser Gln Val Leu Ala Asn Ser 
        35                  40                  45              


Gln Asn Thr Thr Gly Asn Pro Leu Gly Gln Pro Thr Gln Phe Ser Asp 
    50                  55                  60                  


Thr Phe Ser Gly Gln Ser Ile Ser Pro Ala Lys Val Thr Ala Gly Gln 
65                  70                  75                  80  


Pro Thr Pro Ala Val Tyr Thr Ser Ser Glu Lys Pro Glu Ala His Thr 
                85                  90                  95      


Ser Ala Gly Gln Pro Leu Ala Tyr Asn Thr Lys Gln Pro Thr Pro Ile 
            100                 105                 110         


Ala Asn Thr Ser Ser Gln Gln Ala Val Phe Thr Ser Ala Arg Gln Leu 
        115                 120                 125             


Pro Ser Ala Arg Thr Ser Thr Thr Gln Pro Pro Lys Ser Phe Val Tyr 
    130                 135                 140                 


Thr Phe Thr Gln Gln Ser Ser Ser Val Gln Ile Pro Ser Arg Lys Gln 
145                 150                 155                 160 


Ile Thr Val His Asn Pro Ser Thr Gln Pro Thr Ser Thr Val Lys Asn 
                165                 170                 175     


Ser Pro Arg Ser Thr Pro Gly Phe Ile Leu Asp Thr Thr Ser Asn Lys 
            180                 185                 190         


Gln Thr Pro Gln Lys Asn Asn Tyr Asn Ser Ile Ala Ala Ile Leu Ile 
        195                 200                 205             


Gly Val Leu Leu Thr Ser Met Leu Val Ala Ile Ile Ile Ile Val Leu 
    210                 215                 220                 


Trp Lys Cys Leu Arg Lys Pro Val Leu Asn Asp Gln Asn Trp Ala Gly 
225                 230                 235                 240 


Arg Ser Pro Phe Ala Asp Gly Glu Thr Pro Asp Ile Cys Met Asp Asn 
                245                 250                 255     


Ile Arg Glu Asn Glu Ile Ser Thr Lys Arg Thr Ser Ile Ile Ser Leu 
            260                 265                 270         


Thr Pro Trp Lys Pro Ser Lys Ser Thr Leu Leu Ala Asp Asp Leu Glu 
        275                 280                 285             


Ile Lys Leu Phe Glu Ser Ser Glu Asn Ile Glu Asp Ser Asn Asn Pro 
    290                 295                 300                 


Lys Thr Glu Lys Ile Lys Asp Gln Val Asn Gly Thr Ser Glu Asp Ser 
305                 310                 315                 320 


Ala Asp Gly Ser Thr Val Gly Thr Ala Val Ser Ser Ser Asp Asp Ala 
                325                 330                 335     


Asp Leu Pro Pro Pro Pro Pro Leu Leu Asp Leu Glu Gly Gln Glu Ser 
            340                 345                 350         


Asn Gln Ser Asp Lys Pro Thr Met Thr Ile Val Ser Pro Leu Pro Asn 
        355                 360                 365             


Asp Ser Thr Ser Leu Pro Pro Ser Leu Asp Cys Leu Asn Gln Asp Cys 
    370                 375                 380                 


Gly Asp His Lys Ser Glu Ile Ile Gln Ser Phe Pro Pro Leu Asp Ser 
385                 390                 395                 400 


Leu Asn Leu Pro Leu Pro Pro Val Asp Phe Met Lys Asn Gln Glu Asp 
                405                 410                 415     


Ser Asn Leu Glu Ile Gln Cys Gln Glu Phe Ser Ile Pro Pro Asn Ser 
            420                 425                 430         


Asp Gln Asp Leu Asn Glu Ser Leu Pro Pro Pro Pro Ala Glu Leu Leu 
        435                 440                 445             


<210>  3707
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVI5__Homo_sapiens__XP_011540402

<400>  3707

Met Thr Ser Gly Ala Ser Leu Lys Leu Thr Ser Gly Phe Pro Val Ala 
1               5                   10                  15      


Thr Asp Lys Val Ala Glu Lys Leu Ser Ser Thr Leu Ser Trp Val Lys 
            20                  25                  30          


Asn Thr Val Ser His Thr Val Ser Gln Met Ala Ser Gln Val Ala Ser 
        35                  40                  45              


Pro Ser Thr Ser Leu His Thr Thr Ser Ser Ser Thr Thr Leu Ser Thr 
    50                  55                  60                  


Pro Ala Leu Ser Pro Ser Ser Pro Ser Gln Leu Ser Pro Asp Asp Leu 
65                  70                  75                  80  


Glu Leu Leu Ala Lys Leu Glu Glu Gln Asn Arg Leu Leu Glu Thr Asp 
                85                  90                  95      


Ser Lys Ser Leu Arg Ser Val Asn Gly Ser Arg Arg Asn Ser Gly Ser 
            100                 105                 110         


Ser Leu Val Ser Ser Ser Ser Ala Ser Ser Asn Leu Ser His Leu Glu 
        115                 120                 125             


Glu Asp Ser Trp Ile Leu Trp Gly Arg Ile Val Asn Glu Trp Glu Asp 
    130                 135                 140                 


Val Arg Lys Lys Lys Glu Lys Gln Val Lys Pro Phe Glu Cys Trp Val 
145                 150                 155                 160 


Leu Tyr His His Ser Gln Leu Cys Arg Phe Gln Val His Tyr Leu Lys 
                165                 170                 175     


Arg Ser His Thr Glu Glu Leu Val His Lys Gly Ile Pro His His Phe 
            180                 185                 190         


Arg Ala Ile Val Trp Gln Leu Leu Cys Ser Ala Gln Ser Met Pro Ile 
        195                 200                 205             


Lys Asp Gln Tyr Ser Glu Leu Leu Lys Met Thr Ser Pro Cys Glu Lys 
    210                 215                 220                 


Leu Ile Arg Arg Asp Ile Ala Arg Thr Tyr Pro Glu His Asn Phe Phe 
225                 230                 235                 240 


Lys Glu Lys Asp Ser Leu Gly Gln Glu Val Leu Phe Asn Val Met Lys 
                245                 250                 255     


Ala Tyr Ser Leu Val Asp Arg Glu Val Gly Tyr Cys Gln Gly Ser Ala 
            260                 265                 270         


Phe Ile Val Gly Leu Leu Leu Met Gln Met Pro Glu Glu Glu Ala Phe 
        275                 280                 285             


Cys Val Phe Val Lys Leu Met Gln Asp Tyr Arg Leu Arg Glu Leu Phe 
    290                 295                 300                 


Lys Pro Ser Met Ala Glu Leu Gly Leu Cys Met Tyr Gln Phe Glu Cys 
305                 310                 315                 320 


Met Ile Gln Glu His Leu Pro Glu Leu Phe Val His Phe Gln Ser Gln 
                325                 330                 335     


Ser Phe His Thr Ser Met Tyr Ala Ser Ser Trp Phe Leu Thr Ile Phe 
            340                 345                 350         


Leu Thr Thr Phe Pro Leu Pro Ile Ala Thr Arg Ile Phe Asp Ile Phe 
        355                 360                 365             


Met Ser Glu Gly Leu Glu Ile Val Phe Arg Val Gly Leu Ala Leu Leu 
    370                 375                 380                 


Gln Met Asn Gln Ala Glu Leu Met Gln Leu Asp Met Glu Gly Met Leu 
385                 390                 395                 400 


Gln His Phe Gln Lys Val Ile Pro His Gln Phe Asp Gly Val Pro Asp 
                405                 410                 415     


Lys Leu Ile Gln Ala Ala Tyr Gln Val Lys Tyr Asn Ser Lys Lys Met 
            420                 425                 430         


Lys Lys Leu Glu Lys Glu Tyr Thr Thr Ile Lys Thr Lys Glu Met Glu 
        435                 440                 445             


Glu Gln Val Glu Ile Lys Arg Leu Arg Thr Glu Asn Arg Leu Leu Lys 
    450                 455                 460                 


Gln Arg Ile Glu Thr Leu Glu Lys Glu Ser Ala Ser Leu Ala Asp Arg 
465                 470                 475                 480 


Leu Ile Gln Gly Gln Val Thr Arg Ala Gln Glu Ala Glu Glu Asn Tyr 
                485                 490                 495     


Leu Ile Lys Arg Glu Leu Ala Thr Ile Lys Gln Gln Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Lys Leu Glu Gln Ala Glu Asn Thr Ile Arg Lys Leu Gln His 
        515                 520                 525             


Gln Gln Gln Trp His Lys Cys Ser Ser Asn Tyr Asn Glu Asp Phe Val 
    530                 535                 540                 


Leu Gln Leu Glu Lys Glu Leu Val Gln Ala Arg Leu Ser Glu Ala Glu 
545                 550                 555                 560 


Ser Gln Cys Ala Leu Lys Glu Met Gln Asp Lys Val Leu Asp Ile Glu 
                565                 570                 575     


Lys Arg Asn Asn Ser Leu Pro Asp Glu Asn Asn Ile Ala Arg Leu Gln 
            580                 585                 590         


Glu Glu Leu Ile Ala Val Lys Leu Arg Glu Ala Glu Ala Ile Met Gly 
        595                 600                 605             


Leu Lys Glu Leu Arg Gln Gln Val Lys Asp Leu Glu Glu His Trp Gln 
    610                 615                 620                 


Arg His Leu Ala Arg Thr Thr Gly Arg Trp Lys Asp Pro Pro Lys Lys 
625                 630                 635                 640 


Asn Ala Met Asn Glu Leu Gln Asp Glu Leu Met Thr Ile Arg Leu Arg 
                645                 650                 655     


Glu Ala Glu Thr Gln Ala Glu Ile Arg Glu Ile Lys Gln Arg Met Met 
            660                 665                 670         


Glu Met Glu Thr Gln Asn Gln Ile Asn Ser Asn His Leu Arg Arg Ala 
        675                 680                 685             


Glu Gln Glu Val Ile Ser Leu Gln Glu Lys Val Gln Tyr Leu Ser Ala 
    690                 695                 700                 


Gln Asn Lys Gly Leu Leu Thr Gln Leu Ser Glu Ala Lys Arg Lys Gln 
705                 710                 715                 720 


Ala Glu Ile Glu Cys Lys Asn Lys Glu Glu Val Met Ala Val Arg Leu 
                725                 730                 735     


Arg Glu Ala Asp Ser Ile Ala Ala Val Ala Glu Leu Arg Gln His Ile 
            740                 745                 750         


Ala Glu Leu Glu Ile Gln Lys Glu Glu Gly Lys Leu Gln Gly Gln Leu 
        755                 760                 765             


Asn Lys Ser Asp Ser Asn Gln Tyr Ile Gly Glu Leu Lys Asp Gln Ile 
    770                 775                 780                 


Ala Glu Leu Asn His Glu Leu Arg Cys Leu Lys Gly Gln Arg Gly Phe 
785                 790                 795                 800 


Ser Gly Gln Pro Pro Phe Asp Gly Ile His Ile Val Asn His Leu Ile 
                805                 810                 815     


Gly Asp Asp Glu Ser Phe His Ser Ser Asp Glu Asp Phe Ile Asp Asn 
            820                 825                 830         


Ser Leu Gln Glu Thr Gly Val Gly Phe Pro Leu His Gly Lys Ser Gly 
        835                 840                 845             


Ser Met Ser Leu Asp Pro Ala Val Ala Asp Gly Ser Glu Ser Glu Thr 
    850                 855                 860                 


Glu Asp Ser Val Leu Glu Thr Arg Glu Ser Asn Gln Val Val Gln Lys 
865                 870                 875                 880 


Glu Arg Pro Pro Arg Arg Arg Glu Ser Tyr Ser Thr Thr Val 
                885                 890                 


<210>  3708
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVL__Homo_sapiens__NP_057421

<400>  3708

Met Ala Thr Ser Glu Gln Ser Ile Cys Gln Ala Arg Ala Ser Val Met 
1               5                   10                  15      


Val Tyr Asp Asp Thr Ser Lys Lys Trp Val Pro Ile Lys Pro Gly Gln 
            20                  25                  30          


Gln Gly Phe Ser Arg Ile Asn Ile Tyr His Asn Thr Ala Ser Asn Thr 
        35                  40                  45              


Phe Arg Val Val Gly Val Lys Leu Gln Asp Gln Gln Val Val Ile Asn 
    50                  55                  60                  


Tyr Ser Ile Val Lys Gly Leu Lys Tyr Asn Gln Ala Thr Pro Thr Phe 
65                  70                  75                  80  


His Gln Trp Arg Asp Ala Arg Gln Val Tyr Gly Leu Asn Phe Ala Ser 
                85                  90                  95      


Lys Glu Glu Ala Thr Thr Phe Ser Asn Ala Met Leu Phe Ala Leu Asn 
            100                 105                 110         


Ile Met Asn Ser Gln Glu Gly Gly Pro Ser Ser Gln Arg Gln Val Gln 
        115                 120                 125             


Asn Gly Pro Ser Pro Asp Glu Met Asp Ile Gln Arg Arg Gln Val Met 
    130                 135                 140                 


Glu Gln His Gln Gln Gln Arg Gln Glu Ser Leu Glu Arg Arg Thr Ser 
145                 150                 155                 160 


Ala Thr Gly Pro Ile Leu Pro Pro Gly His Pro Ser Ser Ala Ala Ser 
                165                 170                 175     


Ala Pro Val Ser Cys Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Val 
            180                 185                 190         


Pro Pro Pro Pro Thr Gly Ala Thr Pro Pro Pro Pro Pro Pro Leu Pro 
        195                 200                 205             


Ala Gly Gly Ala Gln Gly Ser Ser His Asp Glu Ser Ser Met Ser Gly 
    210                 215                 220                 


Leu Ala Ala Ala Ile Ala Gly Ala Lys Leu Arg Arg Val Gln Arg Pro 
225                 230                 235                 240 


Glu Asp Ala Ser Gly Gly Ser Ser Pro Ser Gly Thr Ser Lys Ser Asp 
                245                 250                 255     


Ala Asn Arg Ala Ser Ser Gly Gly Gly Gly Gly Gly Leu Met Glu Glu 
            260                 265                 270         


Met Asn Lys Leu Leu Ala Lys Arg Arg Lys Ala Ala Ser Gln Ser Asp 
        275                 280                 285             


Lys Pro Ala Glu Lys Lys Glu Asp Glu Ser Gln Met Glu Asp Pro Ser 
    290                 295                 300                 


Thr Ser Pro Ser Pro Gly Thr Arg Ala Ala Ser Gln Pro Pro Asn Ser 
305                 310                 315                 320 


Ser Glu Ala Gly Arg Lys Pro Trp Glu Arg Ser Asn Ser Val Glu Lys 
                325                 330                 335     


Pro Val Ser Ser Ile Leu Ser Arg Thr Pro Ser Val Ala Lys Ser Pro 
            340                 345                 350         


Glu Ala Lys Ser Pro Leu Gln Ser Gln Pro His Ser Arg Met Lys Pro 
        355                 360                 365             


Ala Gly Ser Val Asn Asp Met Ala Leu Asp Ala Phe Asp Leu Asp Arg 
    370                 375                 380                 


Met Lys Gln Glu Ile Leu Glu Glu Val Val Arg Glu Leu His Lys Val 
385                 390                 395                 400 


Lys Glu Glu Ile Ile Asp Ala Ile Arg Gln Glu Leu Ser Gly Ile Ser 
                405                 410                 415     


Thr Thr 
        


<210>  3709
<211>  2033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVPL__Homo_sapiens__NP_001979

<400>  3709

Met Phe Lys Gly Leu Ser Lys Gly Ser Gln Gly Lys Gly Ser Pro Lys 
1               5                   10                  15      


Gly Ser Pro Ala Lys Gly Ser Pro Lys Gly Ser Pro Ser Arg His Ser 
            20                  25                  30          


Arg Ala Ala Thr Gln Glu Leu Ala Leu Leu Ile Ser Arg Met Gln Ala 
        35                  40                  45              


Asn Ala Asp Gln Val Glu Arg Asp Ile Leu Glu Thr Gln Lys Arg Leu 
    50                  55                  60                  


Gln Gln Asp Arg Leu Asn Ser Glu Gln Ser Gln Ala Leu Gln His Gln 
65                  70                  75                  80  


Gln Glu Thr Gly Arg Ser Leu Lys Glu Ala Glu Val Leu Leu Lys Asp 
                85                  90                  95      


Leu Phe Leu Asp Val Asp Lys Ala Arg Arg Leu Lys His Pro Gln Ala 
            100                 105                 110         


Glu Glu Ile Glu Lys Asp Ile Lys Gln Leu His Glu Arg Val Thr Gln 
        115                 120                 125             


Glu Cys Ala Glu Tyr Arg Ala Leu Tyr Glu Lys Met Val Leu Pro Pro 
    130                 135                 140                 


Asp Val Gly Pro Arg Val Asp Trp Ala Arg Val Leu Glu Gln Lys Gln 
145                 150                 155                 160 


Lys Gln Val Cys Ala Gly Gln Tyr Gly Pro Gly Met Ala Glu Leu Glu 
                165                 170                 175     


Gln Gln Ile Ala Glu His Asn Ile Leu Gln Lys Glu Ile Asp Ala Tyr 
            180                 185                 190         


Gly Gln Gln Leu Arg Ser Leu Val Gly Pro Asp Ala Ala Thr Ile Arg 
        195                 200                 205             


Ser Gln Tyr Arg Asp Leu Leu Lys Ala Ala Ser Trp Arg Gly Gln Ser 
    210                 215                 220                 


Leu Gly Ser Leu Tyr Thr His Leu Gln Gly Cys Thr Arg Gln Leu Ser 
225                 230                 235                 240 


Ala Leu Ala Glu Gln Gln Arg Arg Ile Leu Gln Gln Asp Trp Ser Asp 
                245                 250                 255     


Leu Met Ala Asp Pro Ala Gly Val Arg Arg Glu Tyr Glu His Phe Lys 
            260                 265                 270         


Gln His Glu Leu Leu Ser Gln Glu Gln Ser Val Asn Gln Leu Glu Asp 
        275                 280                 285             


Asp Gly Glu Arg Met Val Glu Leu Arg His Pro Ala Val Gly Pro Ile 
    290                 295                 300                 


Gln Ala His Gln Glu Ala Leu Lys Met Glu Trp Gln Asn Phe Leu Asn 
305                 310                 315                 320 


Leu Cys Ile Cys Gln Glu Thr Gln Leu Gln His Val Glu Asp Tyr Arg 
                325                 330                 335     


Arg Phe Gln Glu Glu Ala Asp Ser Val Ser Gln Thr Leu Ala Lys Leu 
            340                 345                 350         


Asn Ser Asn Leu Asp Ala Lys Tyr Ser Pro Ala Pro Gly Gly Pro Pro 
        355                 360                 365             


Gly Ala Pro Thr Glu Leu Leu Gln Gln Leu Glu Ala Glu Glu Lys Arg 
    370                 375                 380                 


Leu Ala Val Thr Glu Arg Ala Thr Gly Asp Leu Gln Arg Arg Ser Arg 
385                 390                 395                 400 


Asp Val Ala Pro Leu Pro Gln Arg Arg Asn Pro Pro Gln Gln Pro Leu 
                405                 410                 415     


His Val Asp Ser Ile Cys Asp Trp Asp Ser Gly Glu Val Gln Leu Leu 
            420                 425                 430         


Gln Gly Glu Arg Tyr Lys Leu Val Asp Asn Thr Asp Pro His Ala Trp 
        435                 440                 445             


Val Val Gln Gly Pro Gly Gly Glu Thr Lys Arg Ala Pro Ala Ala Cys 
    450                 455                 460                 


Phe Cys Ile Pro Ala Pro Asp Pro Asp Ala Val Ala Arg Ala Ser Arg 
465                 470                 475                 480 


Leu Ala Ser Glu Leu Gln Ala Leu Lys Gln Lys Leu Ala Thr Val Gln 
                485                 490                 495     


Ser Arg Leu Lys Ala Ser Ala Val Glu Ser Leu Arg Pro Ser Gln Gln 
            500                 505                 510         


Ala Pro Ser Gly Ser Asp Leu Ala Asn Pro Gln Ala Gln Lys Leu Leu 
        515                 520                 525             


Thr Gln Met Thr Arg Leu Asp Gly Asp Leu Gly Gln Ile Glu Arg Gln 
    530                 535                 540                 


Val Leu Ala Trp Ala Arg Ala Pro Leu Ser Arg Pro Thr Pro Leu Glu 
545                 550                 555                 560 


Asp Leu Glu Gly Arg Ile His Ser His Glu Gly Thr Ala Gln Arg Leu 
                565                 570                 575     


Gln Ser Leu Gly Thr Glu Lys Glu Thr Ala Gln Lys Glu Cys Glu Ala 
            580                 585                 590         


Phe Leu Ser Thr Arg Pro Val Gly Pro Ala Ala Leu Gln Leu Pro Val 
        595                 600                 605             


Ala Leu Asn Ser Val Lys Asn Lys Phe Ser Asp Val Gln Val Leu Cys 
    610                 615                 620                 


Ser Leu Tyr Gly Glu Lys Ala Lys Ala Ala Leu Asp Leu Glu Arg Gln 
625                 630                 635                 640 


Ile Gln Asp Ala Asp Arg Val Ile Arg Gly Phe Glu Ala Thr Leu Val 
                645                 650                 655     


Gln Glu Ala Pro Ile Pro Ala Glu Pro Gly Ala Leu Gln Glu Arg Val 
            660                 665                 670         


Ser Glu Leu Gln Arg Gln Arg Arg Glu Leu Leu Glu Gln Gln Thr Cys 
        675                 680                 685             


Val Leu Arg Leu His Arg Ala Leu Lys Ala Ser Glu His Ala Cys Ala 
    690                 695                 700                 


Ala Leu Gln Asn Asn Phe Gln Glu Phe Cys Gln Asp Leu Pro Arg Gln 
705                 710                 715                 720 


Gln Arg Gln Val Arg Ala Leu Thr Asp Arg Tyr His Ala Val Gly Asp 
                725                 730                 735     


Gln Leu Asp Leu Arg Glu Lys Val Val Gln Asp Ala Ala Leu Thr Tyr 
            740                 745                 750         


Gln Gln Phe Lys Asn Cys Lys Asp Asn Leu Ser Ser Trp Leu Glu His 
        755                 760                 765             


Leu Pro Arg Ser Gln Val Arg Pro Ser Asp Gly Pro Ser Gln Ile Ala 
    770                 775                 780                 


Tyr Lys Leu Gln Ala Gln Lys Arg Leu Thr Gln Glu Ile Gln Ser Arg 
785                 790                 795                 800 


Glu Arg Asp Arg Ala Thr Ala Ser His Leu Ser Gln Ala Leu Gln Ala 
                805                 810                 815     


Ala Leu Gln Asp Tyr Glu Leu Gln Ala Asp Thr Tyr Arg Cys Ser Leu 
            820                 825                 830         


Glu Pro Thr Leu Ala Val Ser Ala Pro Lys Arg Pro Arg Val Ala Pro 
        835                 840                 845             


Leu Gln Glu Ser Ile Gln Ala Gln Glu Lys Asn Leu Ala Lys Ala Tyr 
    850                 855                 860                 


Thr Glu Val Ala Ala Ala Gln Gln Gln Leu Leu Gln Gln Leu Glu Phe 
865                 870                 875                 880 


Ala Arg Lys Met Leu Glu Lys Lys Glu Leu Ser Glu Asp Ile Arg Arg 
                885                 890                 895     


Thr His Asp Ala Lys Gln Gly Ser Glu Ser Pro Ala Gln Ala Gly Arg 
            900                 905                 910         


Glu Ser Glu Ala Leu Lys Ala Gln Leu Glu Glu Glu Arg Lys Arg Val 
        915                 920                 925             


Ala Arg Val Gln His Glu Leu Glu Ala Gln Arg Ser Gln Leu Leu Gln 
    930                 935                 940                 


Leu Arg Thr Gln Arg Pro Leu Glu Arg Leu Glu Glu Lys Glu Val Val 
945                 950                 955                 960 


Glu Phe Tyr Arg Asp Pro Gln Leu Glu Gly Ser Leu Ser Arg Val Lys 
                965                 970                 975     


Ala Gln Val Glu Glu Glu Gly Lys Arg Arg Ala Gly Leu Gln Ala Asp 
            980                 985                 990         


Leu Glu Val Ala Ala Gln Lys Val  Val Gln Leu Glu Ser  Lys Arg Lys 
        995                 1000                 1005             


Thr Met  Gln Pro His Leu Leu  Thr Lys Glu Val Thr  Gln Val Glu 
    1010                 1015                 1020             


Arg Asp  Pro Gly Leu Asp Ser  Gln Ala Ala Gln Leu  Arg Ile Gln 
    1025                 1030                 1035             


Ile Gln  Gln Leu Arg Gly Glu  Asp Ala Val Ile Ser  Ala Arg Leu 
    1040                 1045                 1050             


Glu Gly  Leu Lys Lys Glu Leu  Leu Ala Leu Glu Lys  Arg Glu Val 
    1055                 1060                 1065             


Asp Val  Lys Glu Lys Val Val  Val Lys Glu Val Val  Lys Val Glu 
    1070                 1075                 1080             


Lys Asn  Leu Glu Met Val Lys  Ala Ala Gln Ala Leu  Arg Leu Gln 
    1085                 1090                 1095             


Met Glu  Glu Asp Ala Ala Arg  Arg Lys Gln Ala Glu  Glu Ala Val 
    1100                 1105                 1110             


Ala Lys  Leu Gln Ala Arg Ile  Glu Asp Leu Glu Arg  Ala Ile Ser 
    1115                 1120                 1125             


Ser Val  Glu Pro Lys Val Ile  Val Lys Glu Val Lys  Lys Val Glu 
    1130                 1135                 1140             


Gln Asp  Pro Gly Leu Leu Gln  Glu Ser Ser Arg Leu  Arg Ser Leu 
    1145                 1150                 1155             


Leu Glu  Glu Glu Arg Thr Lys  Asn Ala Thr Leu Ala  Arg Glu Leu 
    1160                 1165                 1170             


Ser Asp  Leu His Ser Lys Tyr  Ser Val Val Glu Lys  Gln Arg Pro 
    1175                 1180                 1185             


Lys Val  Gln Leu Gln Glu Arg  Val His Glu Ile Phe  Gln Val Asp 
    1190                 1195                 1200             


Pro Glu  Thr Glu Gln Glu Ile  Thr Arg Leu Lys Ala  Lys Leu Gln 
    1205                 1210                 1215             


Glu Met  Ala Gly Lys Arg Ser  Gly Val Glu Lys Glu  Val Glu Lys 
    1220                 1225                 1230             


Leu Leu  Pro Asp Leu Glu Val  Leu Arg Ala Gln Lys  Pro Thr Val 
    1235                 1240                 1245             


Glu Tyr  Lys Glu Val Thr Gln  Glu Val Val Arg His  Glu Arg Ser 
    1250                 1255                 1260             


Pro Glu  Val Leu Arg Glu Ile  Asp Arg Leu Lys Ala  Gln Leu Asn 
    1265                 1270                 1275             


Glu Leu  Val Asn Ser His Gly  Arg Ser Gln Glu Gln  Leu Ile Arg 
    1280                 1285                 1290             


Leu Gln  Gly Glu Arg Asp Glu  Trp Arg Arg Glu Arg  Ala Lys Val 
    1295                 1300                 1305             


Glu Thr  Lys Thr Val Ser Lys  Glu Val Val Arg His  Glu Lys Asp 
    1310                 1315                 1320             


Pro Val  Leu Glu Lys Glu Ala  Glu Arg Leu Arg Gln  Glu Val Arg 
    1325                 1330                 1335             


Glu Ala  Ala Gln Lys Arg Arg  Ala Ala Glu Asp Ala  Val Tyr Glu 
    1340                 1345                 1350             


Leu Gln  Ser Lys Arg Leu Leu  Leu Glu Arg Arg Lys  Pro Glu Glu 
    1355                 1360                 1365             


Lys Val  Val Val Gln Glu Val  Val Val Thr Gln Lys  Asp Pro Lys 
    1370                 1375                 1380             


Leu Arg  Glu Glu His Ser Arg  Leu Ser Gly Ser Leu  Asp Glu Glu 
    1385                 1390                 1395             


Val Gly  Arg Arg Arg Gln Leu  Glu Leu Glu Val Gln  Gln Leu Arg 
    1400                 1405                 1410             


Ala Gly  Val Glu Glu Gln Glu  Gly Leu Leu Ser Phe  Gln Glu Asp 
    1415                 1420                 1425             


Arg Ser  Lys Lys Leu Ala Val  Glu Arg Glu Leu Arg  Gln Leu Thr 
    1430                 1435                 1440             


Leu Arg  Ile Gln Glu Leu Glu  Lys Arg Pro Pro Thr  Val Gln Glu 
    1445                 1450                 1455             


Lys Ile  Ile Met Glu Glu Val  Val Lys Leu Glu Lys  Asp Pro Asp 
    1460                 1465                 1470             


Leu Glu  Lys Ser Thr Glu Ala  Leu Arg Trp Asp Leu  Asp Gln Glu 
    1475                 1480                 1485             


Lys Thr  Gln Val Thr Glu Leu  Asn Arg Glu Cys Lys  Asn Leu Gln 
    1490                 1495                 1500             


Val Gln  Ile Asp Val Leu Gln  Lys Ala Lys Ser Gln  Glu Lys Thr 
    1505                 1510                 1515             


Ile Tyr  Lys Glu Val Ile Arg  Val Gln Lys Asp Arg  Val Leu Glu 
    1520                 1525                 1530             


Asp Glu  Arg Ala Arg Val Trp  Glu Met Leu Asn Arg  Glu Arg Thr 
    1535                 1540                 1545             


Ala Arg  Gln Ala Arg Glu Glu  Glu Ala Arg Arg Leu  Arg Glu Arg 
    1550                 1555                 1560             


Ile Asp  Arg Ala Glu Thr Leu  Gly Arg Thr Trp Ser  Arg Glu Glu 
    1565                 1570                 1575             


Ser Glu  Leu Gln Arg Ala Arg  Asp Gln Ala Asp Gln  Glu Cys Gly 
    1580                 1585                 1590             


Arg Leu  Gln Gln Glu Leu Arg  Ala Leu Glu Arg Gln  Lys Gln Gln 
    1595                 1600                 1605             


Gln Thr  Leu Gln Leu Gln Glu  Glu Ser Lys Leu Leu  Ser Gln Lys 
    1610                 1615                 1620             


Thr Glu  Ser Glu Arg Gln Lys  Ala Ala Gln Arg Gly  Gln Glu Leu 
    1625                 1630                 1635             


Ser Arg  Leu Glu Ala Ala Ile  Leu Arg Glu Lys Asp  Gln Ile Tyr 
    1640                 1645                 1650             


Glu Lys  Glu Arg Thr Leu Arg  Asp Leu His Ala Lys  Val Ser Arg 
    1655                 1660                 1665             


Glu Glu  Leu Ser Gln Glu Thr  Gln Thr Arg Glu Thr  Asn Leu Ser 
    1670                 1675                 1680             


Thr Lys  Ile Ser Ile Leu Glu  Pro Glu Thr Gly Lys  Asp Met Ser 
    1685                 1690                 1695             


Pro Tyr  Glu Ala Tyr Lys Arg  Gly Ile Ile Asp Arg  Gly Gln Tyr 
    1700                 1705                 1710             


Leu Gln  Leu Gln Glu Leu Glu  Cys Asp Trp Glu Glu  Val Thr Thr 
    1715                 1720                 1725             


Ser Gly  Pro Cys Gly Glu Glu  Ser Val Leu Leu Asp  Arg Lys Ser 
    1730                 1735                 1740             


Gly Lys  Gln Tyr Ser Ile Glu  Ala Ala Leu Arg Cys  Arg Arg Ile 
    1745                 1750                 1755             


Ser Lys  Glu Glu Tyr His Leu  Tyr Lys Asp Gly His  Leu Pro Ile 
    1760                 1765                 1770             


Ser Glu  Phe Ala Leu Leu Val  Ala Gly Glu Thr Lys  Pro Ser Ser 
    1775                 1780                 1785             


Ser Leu  Ser Ile Gly Ser Ile  Ile Ser Lys Ser Pro  Leu Ala Ser 
    1790                 1795                 1800             


Pro Ala  Pro Gln Ser Thr Ser  Phe Phe Ser Pro Ser  Phe Ser Leu 
    1805                 1810                 1815             


Gly Leu  Gly Asp Asp Ser Phe  Pro Ile Ala Gly Ile  Tyr Asp Thr 
    1820                 1825                 1830             


Thr Thr  Asp Asn Lys Cys Ser  Ile Lys Thr Ala Val  Ala Lys Asn 
    1835                 1840                 1845             


Met Leu  Asp Pro Ile Thr Gly  Gln Lys Leu Leu Glu  Ala Gln Ala 
    1850                 1855                 1860             


Ala Thr  Gly Gly Ile Val Asp  Leu Leu Ser Arg Glu  Arg Tyr Ser 
    1865                 1870                 1875             


Val His  Lys Ala Met Glu Arg  Gly Leu Ile Glu Asn  Thr Ser Thr 
    1880                 1885                 1890             


Gln Arg  Leu Leu Asn Ala Gln  Lys Ala Phe Thr Gly  Ile Glu Asp 
    1895                 1900                 1905             


Pro Val  Thr Lys Lys Arg Leu  Ser Val Gly Glu Ala  Val Gln Lys 
    1910                 1915                 1920             


Gly Trp  Met Pro Arg Glu Ser  Val Leu Pro His Leu  Gln Val Gln 
    1925                 1930                 1935             


His Leu  Thr Gly Gly Leu Ile  Asp Pro Lys Arg Thr  Gly Arg Ile 
    1940                 1945                 1950             


Pro Ile  Gln Gln Ala Leu Leu  Ser Gly Met Ile Ser  Glu Glu Leu 
    1955                 1960                 1965             


Ala Gln  Leu Leu Gln Asp Glu  Ser Ser Tyr Glu Lys  Asp Leu Thr 
    1970                 1975                 1980             


Asp Pro  Ile Ser Lys Glu Arg  Leu Ser Tyr Lys Glu  Ala Met Gly 
    1985                 1990                 1995             


Arg Cys  Arg Lys Asp Pro Leu  Ser Gly Leu Leu Leu  Leu Pro Ala 
    2000                 2005                 2010             


Ala Leu  Glu Gly Tyr Arg Cys  Tyr Arg Ser Ala Ser  Pro Thr Val 
    2015                 2020                 2025             


Pro Arg  Ser Leu Arg 
    2030             


<210>  3710
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVX1__Homo_sapiens__NP_001291449

<400>  3710

Met Arg Arg Tyr Arg Thr Ala Phe Thr Arg Glu Gln Ile Ala Arg Leu 
1               5                   10                  15      


Glu Lys Glu Phe Tyr Arg Glu Asn Tyr Val Ser Arg Pro Arg Arg Cys 
            20                  25                  30          


Glu Leu Ala Ala Ala Leu Asn Leu Pro Glu Thr Thr Ile Lys Val Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Asp Lys Arg Gln Arg Leu Ala Met Thr 
    50                  55                  60                  


Trp Pro His Pro Ala Asp Pro Ala Phe Tyr Thr Tyr Met Met Ser His 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Gly Leu Pro Tyr Pro Phe Pro Ser His Leu Pro 
                85                  90                  95      


Leu Pro Tyr Tyr Ser Pro Val Gly Leu Gly Ala Ala Ser Ala Ala Ser 
            100                 105                 110         


Ala Ala Ala Ser Pro Phe Ser Gly Ser Leu Arg Pro Leu Asp Thr Phe 
        115                 120                 125             


Arg Val Leu Ser Gln Pro Tyr Pro Arg Pro Glu Leu Leu Cys Ala Phe 
    130                 135                 140                 


Arg His Pro Pro Leu Tyr Pro Gly Pro Ala His Gly Leu Gly Ala Ser 
145                 150                 155                 160 


Ala Gly Gly Pro Cys Ser Cys Leu Ala Cys His Ser Gly Pro Ala Asn 
                165                 170                 175     


Gly Leu Ala Pro Arg Ala Ala Ala Ala Ser Asp Phe Thr Cys Ala Ser 
            180                 185                 190         


Thr Ser Arg Ser Asp Ser Phe Leu Thr Phe Ala Pro Ser Val Leu Ser 
        195                 200                 205             


Lys Ala Ser Ser Val Ala Leu Asp Gln Arg Glu Glu Val Pro Leu Thr 
    210                 215                 220                 


Arg 
225 


<210>  3711
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EVX2__Homo_sapiens__XP_011509410

<400>  3711

Met Met Glu Arg Ile Arg Lys Glu Met Ile Leu Met Glu Arg Gly Leu 
1               5                   10                  15      


His Ser Pro Thr Ala Gly Lys Arg Phe Ser Asn Leu Ser Asn Ser Ala 
            20                  25                  30          


Gly Asn Ala Val Leu Glu Ala Leu Glu Asn Ser Gln His Pro Ala Arg 
        35                  40                  45              


Leu Ser Pro Arg Leu Pro Ser Ala Pro Leu His Ser Ala Leu Gly Glu 
    50                  55                  60                  


Leu Pro Ala Lys Gly Lys Phe Glu Ile Asp Thr Leu Phe Asn Leu Gln 
65                  70                  75                  80  


His Thr Gly Ser Glu Ser Thr Val Ser Ser Glu Ile Ser Ser Ala Ala 
                85                  90                  95      


Glu Ser Arg Lys Lys Pro Gly His Tyr Ser Glu Ala Ala Ala Glu Ala 
            100                 105                 110         


Asp Met Ser Ser Asp Val Glu Val Gly Cys Ser Ala Leu Arg Ser Pro 
        115                 120                 125             


Gly Gly Leu Gly Ala Ala Gln Leu Lys Glu Asn Asn Gly Lys Gly Tyr 
    130                 135                 140                 


Ala Glu Ser Gly Ser Ala Ala Gly Thr Thr Thr Ser Ala Ser Gly Ser 
145                 150                 155                 160 


Gly Leu Gly Ser Leu His Gly Gly Ser Gly Gly Ser Gly Gly Ser Ala 
                165                 170                 175     


Ala Leu Gly Gly Ser Gly Ser Gly Ala Asp Gln Val Arg Arg Tyr Arg 
            180                 185                 190         


Thr Ala Phe Thr Arg Glu Gln Ile Ala Arg Leu Glu Lys Glu Phe Tyr 
        195                 200                 205             


Arg Glu Asn Tyr Val Ser Arg Pro Arg Arg Cys Glu Leu Ala Ala Ala 
    210                 215                 220                 


Leu Asn Leu Pro Glu Thr Thr Ile Lys Val Trp Phe Gln Asn Arg Arg 
225                 230                 235                 240 


Met Lys Asp Lys Arg Gln Arg Leu Ala Met Ser Trp Pro His Pro Ala 
                245                 250                 255     


Asp Pro Ser Phe Tyr Thr Tyr Met Met Thr His Ala Ala Ala Thr Gly 
            260                 265                 270         


Ser Leu Pro Tyr Pro Phe His Ser His Val Pro Leu His Tyr Tyr Pro 
        275                 280                 285             


His Val Gly Val Thr Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ser Ser Pro Phe Ala Thr Ser Ile Arg Pro Leu Asp 
305                 310                 315                 320 


Thr Phe Arg Ala Leu Ser His Pro Tyr Ser Arg Pro Glu Leu Leu Cys 
                325                 330                 335     


Ser Phe Arg His Pro Gly Leu Tyr Gln Ala Pro Ala Ala Ala Ala Gly 
            340                 345                 350         


Leu Asn Ser Ala Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        355                 360                 365             


Ala Ala Ser Ser Ala Ala Ala Ala Gly Ala Pro Pro Ser Gly Gly Ser 
    370                 375                 380                 


Ala Pro Cys Ser Cys Leu Ser Cys His Ser Ser Gln Ser Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Leu Gly Ser Arg Gly Gly Gly Gly 
                405                 410                 415     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly 
            420                 425                 430         


Gly Gly Ser Asp Phe Gly Cys Ser Ala Ala Ala Pro Arg Ser Glu Ser 
        435                 440                 445             


Gly Phe Leu Pro Tyr Ser Ala Ala Val Leu Ser Lys Thr Ala Val Ser 
    450                 455                 460                 


Pro Pro Asp Gln Arg Asp Glu Ala Pro Leu Thr Arg 
465                 470                 475     


<210>  3712
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EWSR1__Homo_sapiens__NP_001156757

<400>  3712

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln Ser Ser Phe Arg Gln Asp His Pro 
            260                 265                 270         


Ser Ser Met Gly Val Tyr Gly Gln Glu Ser Gly Gly Phe Ser Gly Pro 
        275                 280                 285             


Gly Glu Asn Arg Ser Met Ser Gly Pro Asp Asn Arg Gly Arg Gly Arg 
    290                 295                 300                 


Gly Gly Phe Asp Arg Gly Gly Met Ser Arg Gly Gly Arg Gly Gly Gly 
305                 310                 315                 320 


Arg Gly Gly Met Gly Ala Gly Glu Arg Gly Gly Phe Asn Lys Pro Gly 
                325                 330                 335     


Gly Pro Met Asp Glu Gly Pro Asp Leu Asp Leu Gly Pro Pro Val Asp 
            340                 345                 350         


Pro Asp Glu Asp Ser Asp Asn Ser Ala Ile Tyr Val Gln Gly Leu Asn 
        355                 360                 365             


Asp Ser Val Thr Leu Asp Asp Leu Ala Asp Phe Phe Lys Gln Cys Gly 
    370                 375                 380                 


Val Val Lys Met Asn Lys Arg Thr Gly Gln Pro Met Ile His Ile Tyr 
385                 390                 395                 400 


Leu Asp Lys Glu Thr Gly Lys Pro Lys Gly Asp Ala Thr Val Ser Tyr 
                405                 410                 415     


Glu Asp Pro Pro Thr Ala Lys Ala Ala Val Glu Trp Phe Asp Gly Lys 
            420                 425                 430         


Asp Phe Gln Gly Ser Lys Leu Lys Val Ser Leu Ala Arg Lys Lys Pro 
        435                 440                 445             


Pro Met Asn Ser Met Arg Gly Gly Leu Pro Pro Arg Glu Gly Arg Gly 
    450                 455                 460                 


Met Pro Pro Pro Leu Arg Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly 
465                 470                 475                 480 


Gly Pro Met Gly Arg Met Gly Gly Arg Gly Gly Asp Arg Gly Gly Phe 
                485                 490                 495     


Pro Pro Arg Gly Pro Arg Gly Ser Arg Gly Asn Pro Ser Gly Gly Gly 
            500                 505                 510         


Asn Val Gln His Arg Ala Gly Asp Trp Gln Cys Pro Asn Pro Gly Cys 
        515                 520                 525             


Gly Asn Gln Asn Phe Ala Trp Arg Thr Glu Cys Asn Gln Cys Lys Ala 
    530                 535                 540                 


Pro Lys Pro Glu Gly Phe Leu Pro Pro Pro Phe Pro Pro Pro Gly Gly 
545                 550                 555                 560 


Asp Arg Gly Arg Gly Gly Pro Gly Gly Met Arg Gly Gly Arg Gly Gly 
                565                 570                 575     


Leu Met Asp Arg Gly Gly Pro Gly Gly Met Phe Arg Gly Gly Arg Gly 
            580                 585                 590         


Gly Asp Arg Gly Gly Phe Arg Gly Gly Arg Gly Met Asp Arg Gly Gly 
        595                 600                 605             


Phe Gly Gly Gly Arg Arg Gly Gly Pro Gly Gly Pro Pro Gly Pro Leu 
    610                 615                 620                 


Met Glu Gln Met Gly Gly Arg Arg Gly Gly Arg Gly Gly Pro Gly Lys 
625                 630                 635                 640 


Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg Pro Tyr 
                645                 650                 655 


<210>  3713
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXD2__Homo_sapiens__NP_001180292

<400>  3713

Met Ser Arg Gln Asn Leu Val Ala Leu Thr Val Thr Thr Leu Leu Gly 
1               5                   10                  15      


Val Ala Val Gly Gly Phe Val Leu Trp Lys Gly Ile Gln Arg Arg Arg 
            20                  25                  30          


Arg Ser Lys Thr Ser Pro Val Thr Gln Gln Pro Gln Gln Lys Val Leu 
        35                  40                  45              


Gly Ser Arg Glu Leu Pro Pro Pro Glu Asp Asp Gln Leu His Ser Ser 
    50                  55                  60                  


Ala Pro Arg Ser Ser Trp Lys Glu Arg Ile Leu Lys Ala Lys Val Val 
65                  70                  75                  80  


Thr Val Ser Gln Glu Ala Glu Trp Asp Gln Ile Glu Pro Leu Leu Arg 
                85                  90                  95      


Ser Glu Leu Glu Asp Phe Pro Val Leu Gly Ile Asp Cys Glu Trp Val 
            100                 105                 110         


Asn Leu Glu Gly Lys Ala Ser Pro Leu Ser Leu Leu Gln Met Ala Ser 
        115                 120                 125             


Pro Ser Gly Leu Cys Val Leu Val Arg Leu Pro Lys Leu Ile Cys Gly 
    130                 135                 140                 


Gly Lys Thr Leu Pro Arg Thr Leu Leu Asp Ile Leu Ala Asp Gly Thr 
145                 150                 155                 160 


Ile Leu Lys Val Gly Val Gly Cys Ser Glu Asp Ala Ser Lys Leu Leu 
                165                 170                 175     


Gln Asp Tyr Gly Leu Val Val Arg Gly Cys Leu Asp Leu Arg Tyr Leu 
            180                 185                 190         


Ala Met Arg Gln Arg Asn Asn Leu Leu Cys Asn Gly Leu Ser Leu Lys 
        195                 200                 205             


Ser Leu Ala Glu Thr Val Leu Asn Phe Pro Leu Asp Lys Ser Leu Leu 
    210                 215                 220                 


Leu Arg Cys Ser Asn Trp Asp Ala Glu Thr Leu Thr Glu Asp Gln Val 
225                 230                 235                 240 


Ile Tyr Ala Ala Arg Asp Ala Gln Ile Ser Val Ala Leu Phe Leu His 
                245                 250                 255     


Leu Leu Gly Tyr Pro Phe Ser Arg Asn Ser Pro Gly Glu Lys Asn Asp 
            260                 265                 270         


Asp His Ser Ser Trp Arg Lys Val Leu Glu Lys Cys Gln Gly Val Val 
        275                 280                 285             


Asp Ile Pro Phe Arg Ser Lys Gly Met Ser Arg Leu Gly Glu Glu Val 
    290                 295                 300                 


Asn Gly Glu Ala Thr Glu Ser Gln Gln Lys Pro Arg Asn Lys Lys Ser 
305                 310                 315                 320 


Lys Met Asp Gly Met Val Pro Gly Asn His Gln Gly Arg Asp Pro Arg 
                325                 330                 335     


Lys His Lys Arg Lys Pro Leu Gly Val Gly Tyr Ser Ala Arg Lys Ser 
            340                 345                 350         


Pro Leu Tyr Asp Asn Cys Phe Leu His Ala Pro Asp Gly Gln Pro Leu 
        355                 360                 365             


Cys Thr Cys Asp Arg Arg Lys Ala Gln Trp Tyr Leu Asp Lys Gly Ile 
    370                 375                 380                 


Gly Glu Leu Val Ser Glu Glu Pro Phe Val Val Lys Leu Arg Phe Glu 
385                 390                 395                 400 


Pro Ala Gly Arg Pro Glu Ser Pro Gly Asp Tyr Tyr Leu Met Val Lys 
                405                 410                 415     


Glu Asn Leu Cys Val Val Cys Gly Lys Arg Asp Ser Tyr Ile Arg Lys 
            420                 425                 430         


Asn Val Ile Pro His Glu Tyr Arg Lys His Phe Pro Ile Glu Met Lys 
        435                 440                 445             


Asp His Asn Ser His Asp Val Leu Leu Leu Cys Thr Ser Cys His Ala 
    450                 455                 460                 


Ile Ser Asn Tyr Tyr Asp Asn His Leu Lys Gln Gln Leu Ala Lys Glu 
465                 470                 475                 480 


Phe Gln Ala Pro Ile Gly Ser Glu Glu Gly Leu Arg Leu Leu Glu Asp 
                485                 490                 495     


Pro Glu Arg Arg Gln Val Arg Ser Gly Ala Arg Ala Leu Leu Asn Ala 
            500                 505                 510         


Glu Ser Leu Pro Thr Gln Arg Lys Glu Glu Leu Leu Gln Ala Leu Arg 
        515                 520                 525             


Glu Phe Tyr Asn Thr Asp Val Val Thr Glu Glu Met Leu Gln Glu Ala 
    530                 535                 540                 


Ala Ser Leu Glu Thr Arg Ile Ser Asn Glu Asn Tyr Val Pro His Gly 
545                 550                 555                 560 


Leu Lys Val Val Gln Cys His Ser Gln Gly Gly Leu Arg Ser Leu Met 
                565                 570                 575     


Gln Leu Glu Ser Arg Trp Arg Gln His Phe Leu Asp Ser Met Gln Pro 
            580                 585                 590         


Lys His Leu Pro Gln Gln Trp Ser Val Asp His Asn His Gln Lys Leu 
        595                 600                 605             


Leu Arg Lys Phe Gly Glu Asp Leu Pro Ile Gln Leu Ser 
    610                 615                 620     


<210>  3714
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXD3__Homo_sapiens__NP_060290

<400>  3714

Met Asp Pro Gly Asp Pro Ala Gly Asp Pro Ala Ala Gly Glu Arg His 
1               5                   10                  15      


Arg Met Gly Arg Asp Pro Leu Leu Leu Leu Gln Ala Leu Gln Thr Leu 
            20                  25                  30          


Trp Ser Thr Arg Glu Arg Lys Gln Leu Arg Glu Glu Ala Trp Arg Gly 
        35                  40                  45              


Phe Ala Ala Leu Asp Asp Pro Leu Ala Gly Leu Leu Asp Met Leu Glu 
    50                  55                  60                  


Ser Cys Arg Gly Gln Arg Gly Glu Gly Pro Ser Leu Ala Ala Trp Ile 
65                  70                  75                  80  


Ser His Gln Leu Gln Cys Trp Leu Gln Ala Gln Pro Cys Pro Ser Leu 
                85                  90                  95      


Ala Gln His Ser Leu Arg Leu Lys Gln Leu Gln Ala Arg Ala Val Lys 
            100                 105                 110         


Val Leu Thr Glu Ser Pro Pro Ser Leu Ala Ala Pro Leu Ala Ser Ile 
        115                 120                 125             


Phe Gln Leu Gln Asp Ala Asp Arg Ser Cys Leu Leu Ala His Val His 
    130                 135                 140                 


Arg Leu His His Glu Gly Arg Phe Arg Glu Ala Ala Thr Leu Gly Ala 
145                 150                 155                 160 


Thr Leu Lys Leu Gln Ser Glu Leu Gly Val Glu Lys Met Ser Ile Pro 
                165                 170                 175     


Leu Leu Leu Gln Asp Lys Val Ala Leu Val Glu Arg Tyr Val Ala Gly 
            180                 185                 190         


Phe Pro Asp Leu Gln Arg Arg Leu Leu Val Leu Met Asp Ser Trp Cys 
        195                 200                 205             


Gln Pro Gly Phe Asp Ile Lys Asp Val Ala Arg Arg Tyr Pro Glu Val 
    210                 215                 220                 


Thr Ser Leu Ser Leu Glu Lys Leu Ser Pro Lys Ala Leu Ser Arg Gln 
225                 230                 235                 240 


Val Leu Arg Leu Gln Glu Arg Tyr Gly Val Ala Pro Ala Leu Cys Pro 
                245                 250                 255     


Asn Ala Ala Ile Gln Gln Arg Leu Ala Ala Leu Arg His Leu Cys His 
            260                 265                 270         


Lys Arg Phe Val Glu Lys Ser Leu Ser Gln Glu Asn Trp Thr Asp His 
        275                 280                 285             


Val Gln Gly Leu Val Gly Gln Ser Pro Trp Leu Gln Glu Gln Leu Ser 
    290                 295                 300                 


Gln Leu Leu Val Ser His Ser Asp Pro Val Thr Ala Ala Gln Cys Ala 
305                 310                 315                 320 


Met Glu Leu Leu Leu Pro Glu Glu Arg Leu Pro Ala Ala Val Ala Val 
                325                 330                 335     


Glu Leu Arg Arg Phe Arg Leu Gln Gly Arg Ala Thr Glu Ala Asp Ser 
            340                 345                 350         


Arg Leu Glu Val Lys Asp Met Lys Asp Arg Tyr Tyr Gln Leu Pro Ile 
        355                 360                 365             


Pro Arg Glu Asn Val His Leu Leu Ala Ser Trp Glu Asp Leu Thr Arg 
    370                 375                 380                 


His Glu Gly Ala Leu Leu Gln Cys His Gln Val Val Gly Val Asp Val 
385                 390                 395                 400 


Glu Trp Thr Pro Val Phe Val Ala Gly Gly Arg Pro Arg Pro Ser Leu 
                405                 410                 415     


Leu Gln Val Ala Val Glu Gly His Val Phe Leu Leu Asp Val Leu Ala 
            420                 425                 430         


Leu Ser Gln Pro Pro Thr Gly Gln Gly Ala Gln Ala Phe Ser Arg Leu 
        435                 440                 445             


Val Ala Gln Leu Leu Ser Asp Pro Ser Ile Thr Lys Leu Gly Tyr Gly 
    450                 455                 460                 


Met Val Gly Asp Leu Gln Lys Leu Gly Thr Ser Cys Pro Ala Leu Ala 
465                 470                 475                 480 


His Val Glu Lys Gln Ile Leu Gly Gly Met Asp Leu Leu Leu Val His 
                485                 490                 495     


Arg Gln Met Arg Val Ala Ser Val Pro Ala Pro Ala Val Asp Arg Ala 
            500                 505                 510         


Arg Glu Leu Arg Gly Leu Ser Leu Leu Val Gln Gln Val Leu Gly Thr 
        515                 520                 525             


Ala Leu Asp Lys Thr Gln Gln Leu Ser Asn Trp Asp Arg Arg Pro Leu 
    530                 535                 540                 


Cys Glu Glu Gln Val Ile Tyr Ala Ala Ala Asp Ala Tyr Cys Leu Leu 
545                 550                 555                 560 


Glu Val His Gln Ala Leu Cys Arg Glu Pro Ala Arg Phe His Leu Ser 
                565                 570                 575     


Glu Asp Leu Ala Gly Ser Arg Arg Pro Arg His Arg Glu Arg Pro Gly 
            580                 585                 590         


Ala Arg Lys Pro Pro Gly Leu Gln Lys Ala Ser Ala Pro Ala Ala Pro 
        595                 600                 605             


Arg Gln Val Pro Val Ala Val Ala Val Ser Glu Gly Ala Ala Pro Gln 
    610                 615                 620                 


Ile Pro Ala Arg Ala Phe Arg Val Val Cys Asp Asn Met Leu Gln Gly 
625                 630                 635                 640 


Leu Ala Arg Ser Leu Arg Cys Leu Gly Val Asp Ala Arg Met Leu Gly 
                645                 650                 655     


Asn Gly Glu Asp His Arg Arg Ala Ala Glu Val Ala Arg Gln Glu Gly 
            660                 665                 670         


Arg Ile Ile Leu Thr Ser Gly Gln Pro Phe His Lys Leu Arg Ala Gln 
        675                 680                 685             


Val Gly Ala Gly Arg Cys Leu Ser Val Asp Cys Ser Leu Lys Ala Gln 
    690                 695                 700                 


Gln Gln Ala Lys Ala Val Leu Lys His Phe Asn Val Arg Val Thr His 
705                 710                 715                 720 


Ala Asp Ile Phe Ser Arg Cys Gln Ala Cys Asn Cys Asp Gln Tyr Leu 
                725                 730                 735     


Lys Val Ser Arg Asp Met Met Lys Gln Leu Met Trp Leu Ser Ser His 
            740                 745                 750         


Gln Glu Gly Pro Arg Ser Ser Gly Asp Glu Ala Thr Gln Ser Gln Ala 
        755                 760                 765             


Val Gln Glu Pro Gly Pro Ala Pro Asp Ala Ala Pro Glu Gly Cys Thr 
    770                 775                 780                 


Tyr Asp Arg Pro Cys Arg Trp Leu Gln Met Ala Asp Leu Arg Ala Glu 
785                 790                 795                 800 


Thr Pro Asp Met Leu Ala Asp Gly Thr Arg Leu Gln Leu Ala Gly Val 
                805                 810                 815     


Pro Val Gly Val Leu Arg Thr Pro Gly Leu Arg Cys Phe Tyr Cys Cys 
            820                 825                 830         


Thr Gly Cys Gly Lys Val Phe Trp Asp Gly Ser His Leu Gly Arg Val 
        835                 840                 845             


Ala Thr His Phe Arg Asp Met Leu Glu Ser Ala Pro Ser Pro Cys Glu 
    850                 855                 860                 


Pro Ser Pro Ala Pro Ser Pro Ala Ser Ser Pro Phe 
865                 870                 875     


<210>  3715
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXO1__Homo_sapiens__NP_003677

<400>  3715

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Phe 
            


<210>  3716
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOC1__Homo_sapiens__NP_001020095

<400>  3716

Met Thr Ala Ile Lys His Ala Leu Gln Arg Asp Ile Phe Thr Pro Asn 
1               5                   10                  15      


Asp Glu Arg Leu Leu Ser Ile Val Asn Val Cys Lys Ala Gly Lys Lys 
            20                  25                  30          


Lys Lys Asn Cys Phe Leu Cys Ala Thr Val Thr Thr Glu Arg Pro Val 
        35                  40                  45              


Gln Val Lys Val Val Lys Val Lys Lys Ser Asp Lys Gly Asp Phe Tyr 
    50                  55                  60                  


Lys Arg Gln Ile Ala Trp Ala Leu Arg Asp Leu Ala Val Val Asp Ala 
65                  70                  75                  80  


Lys Asp Ala Ile Lys Glu Asn Pro Glu Phe Asp Leu His Phe Glu Lys 
                85                  90                  95      


Ile Tyr Lys Trp Val Ala Ser Ser Thr Ala Glu Lys Asn Ala Phe Ile 
            100                 105                 110         


Ser Cys Ile Trp Lys Leu Asn Gln Arg Tyr Leu Arg Lys Lys Ile Asp 
        115                 120                 125             


Phe Val Asn Val Ser Ser Gln Leu Leu Glu Glu Ser Val Pro Ser Gly 
    130                 135                 140                 


Glu Asn Gln Ser Val Thr Gly Gly Asp Glu Glu Val Val Asp Glu Tyr 
145                 150                 155                 160 


Gln Glu Leu Asn Ala Arg Glu Glu Gln Asp Ile Glu Ile Met Met Glu 
                165                 170                 175     


Gly Cys Glu Tyr Ala Ile Ser Asn Ala Glu Ala Phe Ala Glu Lys Leu 
            180                 185                 190         


Ser Arg Glu Leu Gln Val Leu Asp Gly Ala Asn Ile Gln Ser Ile Met 
        195                 200                 205             


Ala Ser Glu Lys Gln Val Asn Ile Leu Met Lys Leu Leu Asp Glu Ala 
    210                 215                 220                 


Leu Lys Glu Val Asp Gln Ile Glu Leu Lys Leu Ser Ser Tyr Glu Glu 
225                 230                 235                 240 


Met Leu Gln Ser Val Lys Glu Gln Met Asp Gln Ile Ser Glu Ser Asn 
                245                 250                 255     


His Leu Ile His Leu Ser Asn Thr Asn Asn Val Lys Leu Leu Ser Glu 
            260                 265                 270         


Ile Glu Phe Leu Val Asn His Met Asp Leu Ala Lys Gly His Ile Lys 
        275                 280                 285             


Ala Leu Gln Glu Gly Asp Leu Ala Ser Ser Arg Gly Ile Glu Ala Cys 
    290                 295                 300                 


Thr Asn Ala Ala Asp Ala Leu Leu Gln Cys Met Asn Val Ala Leu Arg 
305                 310                 315                 320 


Pro Gly His Asp Leu Leu Leu Ala Val Lys Gln Gln Gln Gln Arg Phe 
                325                 330                 335     


Ser Asp Leu Arg Glu Leu Phe Ala Arg Arg Leu Ala Ser His Leu Asn 
            340                 345                 350         


Asn Val Phe Val Gln Gln Gly His Asp Gln Ser Ser Thr Leu Ala Gln 
        355                 360                 365             


His Ser Val Glu Leu Thr Leu Pro Asn His His Pro Phe His Arg Asp 
    370                 375                 380                 


Leu Leu Arg Tyr Ala Lys Leu Met Glu Trp Leu Lys Ser Thr Asp Tyr 
385                 390                 395                 400 


Gly Lys Tyr Glu Gly Leu Thr Lys Asn Tyr Met Asp Tyr Leu Ser Arg 
                405                 410                 415     


Leu Tyr Glu Arg Glu Ile Lys Asp Phe Phe Glu Val Ala Lys Ile Lys 
            420                 425                 430         


Met Thr Gly Thr Thr Lys Glu Ser Lys Lys Phe Ala Thr Leu Pro Arg 
        435                 440                 445             


Lys Glu Ser Ala Val Lys Gln Glu Thr Glu Ser Leu His Gly Ser Ser 
    450                 455                 460                 


Gly Lys Leu Thr Gly Ser Thr Ser Ser Leu Asn Lys Leu Ser Val Gln 
465                 470                 475                 480 


Ser Ser Gly Asn Arg Arg Ser Gln Ser Ser Ser Leu Leu Asp Met Gly 
                485                 490                 495     


Asn Met Ser Ala Ser Asp Leu Asp Val Ala Asp Arg Thr Lys Phe Asp 
            500                 505                 510         


Lys Ile Phe Glu Gln Val Leu Ser Glu Leu Glu Pro Leu Cys Leu Ala 
        515                 520                 525             


Glu Gln Asp Phe Ile Ser Lys Phe Phe Lys Leu Gln Gln His Gln Ser 
    530                 535                 540                 


Met Pro Gly Thr Met Ala Glu Ala Glu Asp Leu Asp Gly Gly Thr Leu 
545                 550                 555                 560 


Ser Arg Gln His Asn Cys Gly Thr Pro Leu Pro Val Ser Ser Glu Lys 
                565                 570                 575     


Asp Met Ile Arg Gln Met Met Ile Lys Ile Phe Arg Cys Ile Glu Pro 
            580                 585                 590         


Glu Leu Asn Asn Leu Ile Ala Leu Gly Asp Lys Ile Asp Ser Phe Asn 
        595                 600                 605             


Ser Leu Tyr Met Leu Val Lys Met Ser His His Val Trp Thr Ala Gln 
    610                 615                 620                 


Asn Val Asp Pro Ala Ser Phe Leu Ser Thr Thr Leu Gly Asn Val Leu 
625                 630                 635                 640 


Val Thr Val Lys Arg Asn Phe Asp Lys Cys Ile Ser Asn Gln Ile Arg 
                645                 650                 655     


Gln Met Glu Glu Val Lys Ile Ser Lys Lys Ser Lys Val Gly Ile Leu 
            660                 665                 670         


Pro Phe Val Ala Glu Phe Glu Glu Phe Ala Gly Leu Ala Glu Ser Ile 
        675                 680                 685             


Phe Lys Asn Ala Glu Arg Arg Gly Asp Leu Asp Lys Ala Tyr Thr Lys 
    690                 695                 700                 


Leu Ile Arg Gly Val Phe Val Asn Val Glu Lys Val Ala Asn Glu Ser 
705                 710                 715                 720 


Gln Lys Thr Pro Arg Asp Val Val Met Met Glu Asn Phe His His Ile 
                725                 730                 735     


Phe Ala Thr Leu Ser Arg Leu Lys Ile Ser Cys Leu Glu Ala Glu Lys 
            740                 745                 750         


Lys Glu Ala Lys Gln Lys Tyr Thr Asp His Leu Gln Ser Tyr Val Ile 
        755                 760                 765             


Tyr Ser Leu Gly Gln Pro Leu Glu Lys Leu Asn His Phe Phe Glu Gly 
    770                 775                 780                 


Val Glu Ala Arg Val Ala Gln Gly Ile Arg Glu Glu Glu Val Ser Tyr 
785                 790                 795                 800 


Gln Leu Ala Phe Asn Lys Gln Glu Leu Arg Lys Val Ile Lys Glu Tyr 
                805                 810                 815     


Pro Gly Lys Glu Val Lys Lys Gly Leu Asp Asn Leu Tyr Lys Lys Val 
            820                 825                 830         


Asp Lys His Leu Cys Glu Glu Glu Asn Leu Leu Gln Val Val Trp His 
        835                 840                 845             


Ser Met Gln Asp Glu Phe Ile Arg Gln Tyr Lys His Phe Glu Gly Leu 
    850                 855                 860                 


Ile Ala Arg Cys Tyr Pro Gly Ser Gly Val Thr Met Glu Phe Thr Ile 
865                 870                 875                 880 


Gln Asp Ile Leu Asp Tyr Cys Ser Ser Ile Ala Gln Ser His 
                885                 890                 


<210>  3717
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOC2__Homo_sapiens__NP_060773

<400>  3717

Met Ser Arg Ser Arg Gln Pro Pro Leu Val Thr Gly Ile Ser Pro Asn 
1               5                   10                  15      


Glu Gly Ile Pro Trp Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly 
            20                  25                  30          


Thr Gly Pro Thr Asp Leu Ile Gly Leu Thr Ile Cys Gly His Asn Cys 
        35                  40                  45              


Leu Leu Thr Ala Glu Trp Met Ser Ala Ser Lys Ile Val Cys Arg Val 
    50                  55                  60                  


Gly Gln Ala Lys Asn Asp Lys Gly Asp Ile Ile Val Thr Thr Lys Ser 
65                  70                  75                  80  


Gly Gly Arg Gly Thr Ser Thr Val Ser Phe Lys Leu Leu Lys Pro Glu 
                85                  90                  95      


Lys Ile Gly Ile Leu Asp Gln Ser Ala Val Trp Val Asp Glu Met Asn 
            100                 105                 110         


Tyr Tyr Asp Met Arg Thr Asp Arg Asn Lys Gly Ile Pro Pro Leu Ser 
        115                 120                 125             


Leu Arg Pro Ala Asn Pro Leu Gly Ile Glu Ile Glu Lys Ser Lys Phe 
    130                 135                 140                 


Ser Gln Lys Asp Leu Glu Met Leu Phe His Gly Met Ser Ala Asp Phe 
145                 150                 155                 160 


Thr Ser Glu Asn Phe Ser Ala Ala Trp Tyr Leu Ile Glu Asn His Ser 
                165                 170                 175     


Asn Thr Ser Phe Glu Gln Leu Lys Met Ala Val Thr Asn Leu Lys Arg 
            180                 185                 190         


Gln Ala Asn Lys Lys Ser Glu Gly Ser Leu Ala Tyr Val Lys Gly Gly 
        195                 200                 205             


Leu Ser Thr Phe Phe Glu Ala Gln Asp Ala Leu Ser Ala Ile His Gln 
    210                 215                 220                 


Lys Leu Glu Ala Asp Gly Thr Glu Lys Val Glu Gly Ser Met Thr Gln 
225                 230                 235                 240 


Lys Leu Glu Asn Val Leu Asn Arg Ala Ser Asn Thr Ala Asp Thr Leu 
                245                 250                 255     


Phe Gln Glu Val Leu Gly Arg Lys Asp Lys Ala Asp Ser Thr Arg Asn 
            260                 265                 270         


Ala Leu Asn Val Leu Gln Arg Phe Lys Phe Leu Phe Asn Leu Pro Leu 
        275                 280                 285             


Asn Ile Glu Arg Asn Ile Gln Lys Gly Asp Tyr Asp Val Val Ile Asn 
    290                 295                 300                 


Asp Tyr Glu Lys Ala Lys Ser Leu Phe Gly Lys Thr Glu Val Gln Val 
305                 310                 315                 320 


Phe Lys Lys Tyr Tyr Ala Glu Val Glu Thr Arg Ile Glu Ala Leu Arg 
                325                 330                 335     


Glu Leu Leu Leu Asp Lys Leu Leu Glu Thr Pro Ser Thr Leu His Asp 
            340                 345                 350         


Gln Lys Arg Tyr Ile Arg Tyr Leu Ser Asp Leu His Ala Ser Gly Asp 
        355                 360                 365             


Pro Ala Trp Gln Cys Ile Gly Ala Gln His Lys Trp Ile Leu Gln Leu 
    370                 375                 380                 


Met His Ser Cys Lys Glu Gly Tyr Val Lys Asp Leu Lys Gly Asn Pro 
385                 390                 395                 400 


Gly Leu His Ser Pro Met Leu Asp Leu Asp Asn Asp Thr Arg Pro Ser 
                405                 410                 415     


Val Leu Gly His Leu Ser Gln Thr Ala Ser Leu Lys Arg Gly Ser Ser 
            420                 425                 430         


Phe Gln Ser Gly Arg Asp Asp Thr Trp Arg Tyr Lys Thr Pro His Arg 
        435                 440                 445             


Val Ala Phe Val Glu Lys Leu Thr Lys Leu Val Leu Ser Gln Leu Pro 
    450                 455                 460                 


Asn Phe Trp Lys Leu Trp Ile Ser Tyr Val Asn Gly Ser Leu Phe Ser 
465                 470                 475                 480 


Glu Thr Ala Glu Lys Ser Gly Gln Ile Glu Arg Ser Lys Asn Val Arg 
                485                 490                 495     


Gln Arg Gln Asn Asp Phe Lys Lys Met Ile Gln Glu Val Met His Ser 
            500                 505                 510         


Leu Val Lys Leu Thr Arg Gly Ala Leu Leu Pro Leu Ser Ile Arg Asp 
        515                 520                 525             


Gly Glu Ala Lys Gln Tyr Gly Gly Trp Glu Val Lys Cys Glu Leu Ser 
    530                 535                 540                 


Gly Gln Trp Leu Ala His Ala Ile Gln Thr Val Arg Leu Thr His Glu 
545                 550                 555                 560 


Ser Leu Thr Ala Leu Glu Ile Pro Asn Asp Leu Leu Gln Thr Ile Gln 
                565                 570                 575     


Asp Leu Ile Leu Asp Leu Arg Val Arg Cys Val Met Ala Thr Leu Gln 
            580                 585                 590         


His Thr Ala Glu Glu Ile Lys Arg Leu Ala Glu Lys Glu Asp Trp Ile 
        595                 600                 605             


Val Asp Asn Glu Gly Leu Thr Ser Leu Pro Cys Gln Phe Glu Gln Cys 
    610                 615                 620                 


Ile Val Cys Ser Leu Gln Ser Leu Lys Gly Val Leu Glu Cys Lys Pro 
625                 630                 635                 640 


Gly Glu Ala Ser Val Phe Gln Gln Pro Lys Thr Gln Glu Glu Val Cys 
                645                 650                 655     


Gln Leu Ser Ile Asn Ile Met Gln Val Phe Ile Tyr Cys Leu Glu Gln 
            660                 665                 670         


Leu Ser Thr Lys Pro Asp Ala Asp Ile Asp Thr Thr His Leu Ser Val 
        675                 680                 685             


Asp Val Ser Ser Pro Asp Leu Phe Gly Ser Ile His Glu Asp Phe Ser 
    690                 695                 700                 


Leu Thr Ser Glu Gln Arg Leu Leu Ile Val Leu Ser Asn Cys Cys Tyr 
705                 710                 715                 720 


Leu Glu Arg His Thr Phe Leu Asn Ile Ala Glu His Phe Glu Lys His 
                725                 730                 735     


Asn Phe Gln Gly Ile Glu Lys Ile Thr Gln Val Ser Met Ala Ser Leu 
            740                 745                 750         


Lys Glu Leu Asp Gln Arg Leu Phe Glu Asn Tyr Ile Glu Leu Lys Ala 
        755                 760                 765             


Asp Pro Ile Val Gly Ser Leu Glu Pro Gly Ile Tyr Ala Gly Tyr Phe 
    770                 775                 780                 


Asp Trp Lys Asp Cys Leu Pro Pro Thr Gly Val Arg Asn Tyr Leu Lys 
785                 790                 795                 800 


Glu Ala Leu Val Asn Ile Ile Ala Val His Ala Glu Val Phe Thr Ile 
                805                 810                 815     


Ser Lys Glu Leu Val Pro Arg Val Leu Ser Lys Val Ile Glu Ala Val 
            820                 825                 830         


Ser Glu Glu Leu Ser Arg Leu Met Gln Cys Val Ser Ser Phe Ser Lys 
        835                 840                 845             


Asn Gly Ala Leu Gln Ala Arg Leu Glu Ile Cys Ala Leu Arg Asp Thr 
    850                 855                 860                 


Val Ala Val Tyr Leu Thr Pro Glu Ser Lys Ser Ser Phe Lys Gln Ala 
865                 870                 875                 880 


Leu Glu Ala Leu Pro Gln Leu Ser Ser Gly Ala Asp Lys Lys Leu Leu 
                885                 890                 895     


Glu Glu Leu Leu Asn Lys Phe Lys Ser Ser Met His Leu Gln Leu Thr 
            900                 905                 910         


Cys Phe Gln Ala Ala Ser Ser Thr Met Met Lys Thr 
        915                 920                 


<210>  3718
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOC3L1__Homo_sapiens__NP_848611

<400>  3718

Met Asp Ser Ala Ala Lys Asp Glu Met Gln Pro Ala Leu Ser Pro Gly 
1               5                   10                  15      


Pro Glu Trp Pro Glu Gln Glu Arg Ala Glu Gln Leu Ala Arg Gly Ala 
            20                  25                  30          


Ala Leu Lys Trp Ala Ser Gly Ile Phe Tyr Arg Pro Glu Gln Leu Ala 
        35                  40                  45              


Arg Leu Gly Gln Tyr Arg Ser Arg Glu Val Gln Arg Thr Cys Ser Leu 
    50                  55                  60                  


Glu Ser Arg Leu Lys Ser Val Met Gln Ser Tyr Leu Glu Gly Val Gln 
65                  70                  75                  80  


Thr Gly Val Trp Gln Leu Ala Gln Ala Ile Glu Val Val Gln Gly Thr 
                85                  90                  95      


Arg Glu Ala Leu Ser Gln Ala Arg Gly Leu Leu Gln Gly Met Ser Gln 
            100                 105                 110         


Ala Leu Gln Thr Leu Glu Pro Leu Arg Glu Arg Val Ala Gln His Lys 
        115                 120                 125             


Gln Leu Gln Ala Leu Ser His Leu Leu Pro Arg Leu Arg Ala Val Pro 
    130                 135                 140                 


Ala Ala Val Ser His Thr Gln Thr Leu Ile Asp Gly Gln Gln Phe Leu 
145                 150                 155                 160 


Glu Ala Tyr Val Ser Leu Arg Glu Leu Glu Gln Leu Arg Glu Asp Thr 
                165                 170                 175     


Trp Ala Pro Leu Gly Gly Leu Glu Leu Pro Val Phe Gln Gly Leu Asp 
            180                 185                 190         


Leu Leu Phe Glu Ala Leu Gly Gln Ala Val Glu Ala Ala Ala Gly Ala 
        195                 200                 205             


Ala Gly Lys Leu Ala Arg Glu Asp Pro Ala Leu Leu Val Ala Ala Val 
    210                 215                 220                 


Arg Val Ala Glu Val Glu Thr Gly Arg Thr Thr Pro Leu Gly Gln Val 
225                 230                 235                 240 


Pro Arg Asp Trp Arg Gln Arg Cys Leu Arg Ala Leu Gln Glu Gly Leu 
                245                 250                 255     


Glu Gln Ala His Phe Gly Ser Pro Leu Leu Pro Ala Pro Gly Ala Leu 
            260                 265                 270         


Pro Gly Trp Leu Glu Ala Leu Arg Val Ala Leu Pro Val Glu Leu Ala 
        275                 280                 285             


Thr Ala Glu Ala Leu Val Ala Pro Cys Cys Pro Pro Gln Tyr Asn Val 
    290                 295                 300                 


Val Gln Leu Trp Ala His Thr Leu His Ser Gly Leu Arg Arg Ser Leu 
305                 310                 315                 320 


Gln Asn Leu Leu Ala Gly Pro Glu Leu Glu Ala Ala Asp Ala Phe Ala 
                325                 330                 335     


Leu Leu His Trp Ala Leu His Val Tyr Leu Gly Gln Glu Met Met Gly 
            340                 345                 350         


Ser Leu Glu Leu Gly Pro Glu Ala Asp Val Ser Gln Leu Glu Pro Leu 
        355                 360                 365             


Leu Thr Leu Glu Asn Ile Glu Gln Leu Glu Ala Thr Phe Val Ala Asn 
    370                 375                 380                 


Ile Gln Ala Ser Val Ser Gln Trp Leu Gln Asn Ala Leu Asp Gly Glu 
385                 390                 395                 400 


Val Ala Glu Trp Gly Arg Glu His Gly Pro Asn Thr Asp Pro Ser Gly 
                405                 410                 415     


Ser Tyr Tyr Ser Pro Met Pro Ala Ile Val Leu Gln Ile Leu Glu Glu 
            420                 425                 430         


Asn Ile Arg Val Ala Ser Leu Val Ser Glu Ser Leu Gln Gln Arg Val 
        435                 440                 445             


His Gly Met Ala Leu Ser Glu Leu Gly Thr Phe Leu Arg Ser Phe Ser 
    450                 455                 460                 


Asp Ala Leu Ile Arg Phe Ser Arg Asp His Phe Arg Gly Lys Ser Met 
465                 470                 475                 480 


Ala Pro His Tyr Val Pro Tyr Leu Leu Ala Ala Leu Asn His Lys Ser 
                485                 490                 495     


Ala Leu Ser Ser Ser Val Ser Val Leu Gln Leu Asp Gly Ala Pro Ser 
            500                 505                 510         


Gly Ala Leu Ala Pro Val Glu Ala Ala Leu Asp Glu Leu Gln Arg Arg 
        515                 520                 525             


Ile Tyr Arg Leu Val Leu Glu Ala Leu Gln Ala Glu Leu Gln Pro Leu 
    530                 535                 540                 


Phe Ala Asp Leu Pro Ser Arg Gln Trp Leu Ser Ser Pro Glu Leu Leu 
545                 550                 555                 560 


Gln Ser Val Cys Glu Arg Thr Gly Arg Phe Cys Arg Asp Phe Trp Arg 
                565                 570                 575     


Val Arg Asn Pro Thr Val Gln Leu Leu Leu Ala Glu Ala Glu Arg Ala 
            580                 585                 590         


Val Val Leu Gln Tyr Leu Ser Ala Leu Met Gln Gly Arg Leu Val Cys 
        595                 600                 605             


Arg Gly Ala Asp Glu Arg Thr Gln Ala Ala Glu Arg Leu Arg His Asp 
    610                 615                 620                 


Ala Ala Gln Leu Gln Gln Leu Phe Leu Ser Leu Gly Leu Glu Glu Asn 
625                 630                 635                 640 


Ala His Cys Ala Pro Val Leu Leu Ala Leu Arg Glu Leu Leu Asn Leu 
                645                 650                 655     


Arg Asp Pro Ala Leu Leu Gly Leu Glu Val Ala Gly Leu Arg Gln Gln 
            660                 665                 670         


Phe Pro Asp Val Ser Glu Asp His Val Ser Ala Leu Leu Gly Leu Arg 
        675                 680                 685             


Gly Asp Leu Ser Arg Glu Gln His Leu Ala Ala Leu Ser Ser Leu Gln 
    690                 695                 700                 


Ala Ala Leu Pro Pro Ser Pro Arg Ala Ser Arg Arg Val Leu Phe Ser 
705                 710                 715                 720 


Leu Val Pro Ala Pro Ala Leu Ala Pro Ala Ser Cys Leu Pro Ser Gly 
                725                 730                 735     


Ser Cys Ala Arg Ala Leu Leu Leu Ala Glu 
            740                 745     


<210>  3719
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOC3L2__Homo_sapiens__NP_612635

<400>  3719

Met Ala Ala Leu Glu Asn Gly Glu Leu Gly Pro Leu Leu Ser Pro Gly 
1               5                   10                  15      


Thr Leu Arg Gly Leu Glu Asp Glu Cys Val Thr Asp Val Lys Ala Gln 
            20                  25                  30          


Thr Arg Ala Ala Leu Leu Arg Val Leu Gln Glu Asp Glu Glu His Trp 
        35                  40                  45              


Gly Ser Leu Glu Asp Gln Pro Ser Ser Leu Ala Gln Asp Val Cys Glu 
    50                  55                  60                  


Leu Leu Glu Glu His Thr Glu Arg Ala Pro Arg Ile Ser Gln Glu Phe 
65                  70                  75                  80  


Gly Glu Arg Met Ala His Cys Cys Leu Gly Gly Leu Ala Glu Phe Leu 
                85                  90                  95      


Gln Ser Phe Gln Gln Arg Val Glu Arg Phe His Glu Asn Pro Ala Val 
            100                 105                 110         


Arg Glu Met Leu Pro Asp Thr Tyr Ile Ser Lys Thr Ile Ala Leu Val 
        115                 120                 125             


Asn Cys Gly Pro Pro Leu Arg Ala Leu Ala Glu Arg Leu Ala Arg Val 
    130                 135                 140                 


Gly Pro Pro Glu Ser Glu Pro Ala Arg Glu Ala Ser Ala Ser Ala Leu 
145                 150                 155                 160 


Asp His Val Thr Arg Leu Cys His Arg Val Val Ala Asn Leu Leu Phe 
                165                 170                 175     


Gln Glu Leu Gln Pro His Phe Asn Lys Leu Met Arg Arg Lys Trp Leu 
            180                 185                 190         


Ser Ser Pro Glu Ala Leu Asp Gly Ile Val Gly Thr Leu Gly Ala Gln 
        195                 200                 205             


Ala Leu Ala Leu Arg Arg Met Gln Asp Glu Pro Tyr Gln Ala Leu Val 
    210                 215                 220                 


Ala Glu Leu His Arg Arg Ala Leu Val Glu Tyr Val Arg Pro Leu Leu 
225                 230                 235                 240 


Arg Gly Arg Leu Arg Cys Ser Ser Ala Arg Thr Arg Ser Arg Val Ala 
                245                 250                 255     


Gly Arg Leu Arg Glu Asp Ala Ala Gln Leu Gln Arg Leu Phe Arg Arg 
            260                 265                 270         


Leu Glu Ser Gln Ala Ser Trp Leu Asp Ala Val Val Pro His Leu Ala 
        275                 280                 285             


Glu Val Met Gln Leu Glu Asp Thr Pro Ser Ile Gln Val Glu Val Gly 
    290                 295                 300                 


Val Leu Val Arg Asp Tyr Pro Asp Ile Arg Gln Lys His Val Ala Ala 
305                 310                 315                 320 


Leu Leu Asp Ile Arg Gly Leu Arg Asn Thr Ala Ala Arg Gln Glu Ile 
                325                 330                 335     


Leu Ala Val Ala Arg Asp Leu Glu Leu Ser Glu Glu Gly Ala Leu Ser 
            340                 345                 350         


Pro Pro Arg Asp Arg Ala Phe Phe Ala Asp Ile Pro Val Pro Arg Pro 
        355                 360                 365             


Ser Phe Cys Leu Ser Leu Pro Leu Phe Leu Gly Arg Leu Pro Leu Ser 
    370                 375                 380                 


Arg Leu Ala Arg Pro Ser Leu Ala Cys Leu Pro Arg Pro Arg Pro Pro 
385                 390                 395                 400 


Ser Leu Ala Arg Pro Arg Ala Gln Arg 
                405                 


<210>  3720
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOC4__Homo_sapiens__NP_001032203

<400>  3720

Met Ala Ala Glu Ala Ala Gly Gly Lys Tyr Arg Ser Thr Val Ser Lys 
1               5                   10                  15      


Ser Lys Asp Pro Ser Gly Leu Leu Ile Ser Val Ile Arg Thr Leu Ser 
            20                  25                  30          


Thr Ser Asp Asp Val Glu Asp Arg Glu Asn Glu Lys Gly Arg Leu Glu 
        35                  40                  45              


Glu Ala Tyr Glu Lys Cys Asp Arg Asp Leu Asp Glu Leu Ile Val Gln 
    50                  55                  60                  


His Tyr Thr Glu Leu Thr Thr Ala Ile Arg Thr Tyr Gln Ser Ile Thr 
65                  70                  75                  80  


Glu Arg Ile Thr Asn Ser Arg Asn Lys Ile Lys Gln Val Lys Glu Asn 
                85                  90                  95      


Leu Leu Ser Cys Lys Met Leu Leu His Cys Lys Arg Asp Glu Leu Arg 
            100                 105                 110         


Lys Leu Trp Ile Glu Gly Ile Glu His Lys His Val Leu Asn Leu Leu 
        115                 120                 125             


Asp Glu Ile Glu Asn Ile Lys Gln Val Pro Gln Lys Leu Glu Gln Cys 
    130                 135                 140                 


Met Ala Ser Lys His Tyr Leu Ser Ala Thr Asp Met Leu Val Ser Ala 
145                 150                 155                 160 


Val Glu Ser Leu Glu Gly Pro Leu Leu Gln Val Glu Gly Leu Ser Asp 
                165                 170                 175     


Leu Arg Leu Glu Leu His Ser Lys Lys Met Asn Leu His Leu Val Leu 
            180                 185                 190         


Ile Asp Glu Leu His Arg His Leu Tyr Ile Lys Ser Thr Ser Arg Val 
        195                 200                 205             


Val Gln Arg Asn Lys Glu Lys Gly Lys Ile Ser Ser Leu Val Lys Asp 
    210                 215                 220                 


Ala Ser Val Pro Leu Ile Asp Val Thr Asn Leu Pro Thr Pro Arg Lys 
225                 230                 235                 240 


Phe Leu Asp Thr Ser His Tyr Ser Thr Ala Gly Ser Ser Ser Val Arg 
                245                 250                 255     


Glu Ile Asn Leu Gln Asp Ile Lys Glu Asp Leu Glu Leu Asp Pro Glu 
            260                 265                 270         


Glu Asn Ser Thr Leu Phe Met Gly Ile Leu Ile Lys Gly Leu Ala Lys 
        275                 280                 285             


Leu Lys Lys Ile Pro Glu Thr Val Lys Ala Ile Ile Glu Arg Leu Glu 
    290                 295                 300                 


Gln Glu Leu Lys Gln Ile Val Lys Arg Ser Thr Thr Gln Val Ala Asp 
305                 310                 315                 320 


Ser Gly Tyr Gln Arg Gly Glu Asn Val Thr Val Glu Asn Gln Pro Arg 
                325                 330                 335     


Leu Leu Leu Glu Leu Leu Glu Leu Leu Phe Asp Lys Phe Asn Ala Val 
            340                 345                 350         


Ala Ala Ala His Ser Val Val Leu Gly Tyr Leu Gln Asp Thr Val Val 
        355                 360                 365             


Thr Pro Leu Thr Gln Gln Glu Asp Ile Lys Leu Tyr Asp Met Ala Asp 
    370                 375                 380                 


Val Trp Val Lys Ile Gln Asp Val Leu Gln Met Leu Leu Thr Glu Tyr 
385                 390                 395                 400 


Leu Asp Met Lys Asn Thr Arg Thr Ala Ser Glu Pro Ser Ala Gln Leu 
                405                 410                 415     


Ser Tyr Ala Ser Thr Gly Arg Glu Phe Ala Ala Phe Phe Ala Lys Lys 
            420                 425                 430         


Lys Pro Gln Arg Pro Lys Asn Ser Leu Phe Lys Phe Glu Ser Ser Ser 
        435                 440                 445             


His Ala Ile Ser Met Ser Ala Tyr Leu Arg Glu Gln Arg Arg Glu Leu 
    450                 455                 460                 


Tyr Ser Arg Ser Gly Glu Leu Gln Gly 
465                 470             


<210>  3721
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOC5__Homo_sapiens__NP_006535

<400>  3721

Met Ala Thr Thr Ala Glu Leu Phe Glu Glu Pro Phe Val Ala Asp Glu 
1               5                   10                  15      


Tyr Ile Glu Arg Leu Val Trp Arg Thr Pro Gly Gly Gly Ser Arg Gly 
            20                  25                  30          


Gly Pro Glu Ala Phe Asp Pro Lys Arg Leu Leu Glu Glu Phe Val Asn 
        35                  40                  45              


His Ile Gln Glu Leu Gln Ile Met Asp Glu Arg Ile Gln Arg Lys Val 
    50                  55                  60                  


Glu Lys Leu Glu Gln Gln Cys Gln Lys Glu Ala Lys Glu Phe Ala Lys 
65                  70                  75                  80  


Lys Val Gln Glu Leu Gln Lys Ser Asn Gln Val Ala Phe Gln His Phe 
                85                  90                  95      


Gln Glu Leu Asp Glu His Ile Ser Tyr Val Ala Thr Lys Val Cys His 
            100                 105                 110         


Leu Gly Asp Gln Leu Glu Gly Val Asn Thr Pro Arg Gln Arg Ala Val 
        115                 120                 125             


Glu Ala Gln Lys Leu Met Lys Tyr Phe Asn Glu Phe Leu Asp Gly Glu 
    130                 135                 140                 


Leu Lys Ser Asp Val Phe Thr Asn Ser Glu Lys Ile Lys Glu Ala Ala 
145                 150                 155                 160 


Asp Ile Ile Gln Lys Leu His Leu Ile Ala Gln Glu Leu Pro Phe Asp 
                165                 170                 175     


Arg Phe Ser Glu Val Lys Ser Lys Ile Ala Ser Lys Tyr His Asp Leu 
            180                 185                 190         


Glu Cys Gln Leu Ile Gln Glu Phe Thr Ser Ala Gln Arg Arg Gly Glu 
        195                 200                 205             


Ile Ser Arg Met Arg Glu Val Ala Ala Val Leu Leu His Phe Lys Gly 
    210                 215                 220                 


Tyr Ser His Cys Val Asp Val Tyr Ile Lys Gln Cys Gln Glu Gly Ala 
225                 230                 235                 240 


Tyr Leu Arg Asn Asp Ile Phe Glu Asp Ala Gly Ile Leu Cys Gln Arg 
                245                 250                 255     


Val Asn Lys Gln Val Gly Asp Ile Phe Ser Asn Pro Glu Thr Val Leu 
            260                 265                 270         


Ala Lys Leu Ile Gln Asn Val Phe Glu Ile Lys Leu Gln Ser Phe Val 
        275                 280                 285             


Lys Glu Gln Leu Glu Glu Cys Arg Lys Ser Asp Ala Glu Gln Tyr Leu 
    290                 295                 300                 


Lys Asn Leu Tyr Asp Leu Tyr Thr Arg Thr Thr Asn Leu Ser Ser Lys 
305                 310                 315                 320 


Leu Met Glu Phe Asn Leu Gly Thr Asp Lys Gln Thr Phe Leu Ser Lys 
                325                 330                 335     


Leu Ile Lys Ser Ile Phe Ile Ser Tyr Leu Glu Asn Tyr Ile Glu Val 
            340                 345                 350         


Glu Thr Gly Tyr Leu Lys Ser Arg Ser Ala Met Ile Leu Gln Arg Tyr 
        355                 360                 365             


Tyr Asp Ser Lys Asn His Gln Lys Arg Ser Ile Gly Thr Gly Gly Ile 
    370                 375                 380                 


Gln Asp Leu Lys Glu Arg Ile Arg Gln Arg Thr Asn Leu Pro Leu Gly 
385                 390                 395                 400 


Pro Ser Ile Asp Thr His Gly Glu Thr Phe Leu Ser Gln Glu Val Val 
                405                 410                 415     


Val Asn Leu Leu Gln Glu Thr Lys Gln Ala Phe Glu Arg Cys His Arg 
            420                 425                 430         


Leu Ser Asp Pro Ser Asp Leu Pro Arg Asn Ala Phe Arg Ile Phe Thr 
        435                 440                 445             


Ile Leu Val Glu Phe Leu Cys Ile Glu His Ile Asp Tyr Ala Leu Glu 
    450                 455                 460                 


Thr Gly Leu Ala Gly Ile Pro Ser Ser Asp Ser Arg Asn Ala Asn Leu 
465                 470                 475                 480 


Tyr Phe Leu Asp Val Val Gln Gln Ala Asn Thr Ile Phe His Leu Phe 
                485                 490                 495     


Asp Lys Gln Phe Asn Asp His Leu Met Pro Leu Ile Ser Ser Ser Pro 
            500                 505                 510         


Lys Leu Ser Glu Cys Leu Gln Lys Lys Lys Glu Ile Ile Glu Gln Met 
        515                 520                 525             


Glu Met Lys Leu Asp Thr Gly Ile Asp Arg Thr Leu Asn Cys Met Ile 
    530                 535                 540                 


Gly Gln Met Lys His Ile Leu Ala Ala Glu Gln Lys Lys Thr Asp Phe 
545                 550                 555                 560 


Lys Pro Glu Asp Glu Asn Asn Val Leu Ile Gln Tyr Thr Asn Ala Cys 
                565                 570                 575     


Val Lys Val Cys Ala Tyr Val Arg Lys Gln Val Glu Lys Ile Lys Asn 
            580                 585                 590         


Ser Met Asp Gly Lys Asn Val Asp Thr Val Leu Met Glu Leu Gly Val 
        595                 600                 605             


Arg Phe His Arg Leu Ile Tyr Glu His Leu Gln Gln Tyr Ser Tyr Ser 
    610                 615                 620                 


Cys Met Gly Gly Met Leu Ala Ile Cys Asp Val Ala Glu Tyr Arg Lys 
625                 630                 635                 640 


Cys Ala Lys Asp Phe Lys Ile Pro Met Val Leu His Leu Phe Asp Thr 
                645                 650                 655     


Leu His Ala Leu Cys Asn Leu Leu Val Val Ala Pro Asp Asn Leu Lys 
            660                 665                 670         


Gln Val Cys Ser Gly Glu Gln Leu Ala Asn Leu Asp Lys Asn Ile Leu 
        675                 680                 685             


His Ser Phe Val Gln Leu Arg Ala Asp Tyr Arg Ser Ala Arg Leu Ala 
    690                 695                 700                 


Arg His Phe Ser 
705             


<210>  3722
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOC7__Homo_sapiens__NP_001013861

<400>  3722

Met Ile Pro Pro Gln Glu Ala Ser Ala Arg Arg Arg Glu Ile Glu Asp 
1               5                   10                  15      


Lys Leu Lys Gln Glu Glu Glu Thr Leu Ser Phe Ile Arg Asp Ser Leu 
            20                  25                  30          


Glu Lys Ser Asp Gln Leu Thr Lys Asn Met Val Ser Ile Leu Ser Ser 
        35                  40                  45              


Phe Glu Ser Arg Leu Met Lys Leu Glu Asn Ser Ile Ile Pro Val His 
    50                  55                  60                  


Lys Gln Thr Glu Asn Leu Gln Arg Leu Gln Glu Asn Val Glu Lys Thr 
65                  70                  75                  80  


Leu Ser Cys Leu Asp His Val Ile Ser Tyr Tyr His Val Ala Ser Asp 
                85                  90                  95      


Thr Glu Lys Ile Ile Arg Glu Gly Pro Thr Gly Arg Leu Glu Glu Tyr 
            100                 105                 110         


Leu Gly Ser Met Ala Lys Ile Gln Lys Ala Val Glu Tyr Phe Gln Asp 
        115                 120                 125             


Asn Ser Pro Asp Ser Pro Glu Leu Asn Lys Val Lys Leu Leu Phe Glu 
    130                 135                 140                 


Arg Gly Lys Glu Ala Leu Glu Ser Glu Phe Arg Ser Leu Met Thr Arg 
145                 150                 155                 160 


His Ser Lys Val Val Ser Pro Val Leu Ile Leu Asp Leu Ile Ser Gly 
                165                 170                 175     


Asp Asp Asp Leu Glu Ala Gln Glu Asp Val Thr Leu Glu His Leu Pro 
            180                 185                 190         


Glu Ser Val Leu Gln Asp Val Ile Arg Ile Ser Arg Trp Leu Val Glu 
        195                 200                 205             


Tyr Gly Arg Asn Gln Asp Phe Met Asn Val Tyr Tyr Gln Ile Arg Ser 
    210                 215                 220                 


Ser Gln Leu Asp Arg Ser Ile Lys Gly Leu Lys Glu His Phe His Lys 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Gly Val Pro Tyr Ser Pro Ala Ile Pro Asn Lys 
                245                 250                 255     


Arg Lys Asp Thr Pro Thr Lys Lys Pro Val Lys Arg Pro Gly Thr Ile 
            260                 265                 270         


Arg Lys Ala Gln Asn Leu Leu Lys Gln Tyr Ser Gln His Gly Leu Asp 
        275                 280                 285             


Gly Lys Lys Gly Gly Ser Asn Leu Ile Pro Leu Glu Gly Arg Asp Asp 
    290                 295                 300                 


Met Leu Asp Val Glu Thr Asp Ala Tyr Ile His Cys Val Ser Ala Phe 
305                 310                 315                 320 


Val Lys Leu Ala Gln Ser Glu Tyr Gln Leu Leu Ala Asp Ile Ile Pro 
                325                 330                 335     


Glu His His Gln Lys Lys Thr Phe Asp Ser Leu Ile Gln Asp Ala Leu 
            340                 345                 350         


Asp Gly Leu Met Leu Glu Gly Glu Asn Ile Val Ser Ala Ala Arg Lys 
        355                 360                 365             


Ala Ile Val Arg His Asp Phe Ser Thr Val Leu Thr Val Phe Pro Ile 
    370                 375                 380                 


Leu Arg His Leu Lys Gln Thr Lys Pro Glu Phe Asp Gln Val Leu Gln 
385                 390                 395                 400 


Gly Thr Ala Ala Ser Thr Lys Asn Lys Leu Pro Gly Leu Ile Thr Ser 
                405                 410                 415     


Met Glu Thr Ile Gly Ala Lys Ala Leu Glu Asp Phe Ala Asp Asn Ile 
            420                 425                 430         


Lys Asn Asp Pro Asp Lys Glu Tyr Asn Met Pro Lys Asp Gly Thr Val 
        435                 440                 445             


His Glu Leu Thr Ser Asn Ala Ile Leu Phe Leu Gln Gln Leu Leu Asp 
    450                 455                 460                 


Phe Gln Glu Thr Ala Gly Ala Met Leu Ala Ser Gln Glu Thr Ser Ser 
465                 470                 475                 480 


Ser Ala Thr Ser Tyr Ser Ser Glu Phe Ser Lys Arg Leu Leu Ser Thr 
                485                 490                 495     


Tyr Ile Cys Lys Val Leu Gly Asn Leu Gln Leu Asn Leu Leu Ser Lys 
            500                 505                 510         


Ser Lys Val Tyr Glu Asp Pro Ala Leu Ser Ala Ile Phe Leu His Asn 
        515                 520                 525             


Asn Tyr Asn Tyr Ile Leu Lys Ser Leu Glu Lys Ser Glu Leu Ile Gln 
    530                 535                 540                 


Leu Val Ala Val Thr Gln Lys Thr Ala Glu Arg Ser Tyr Arg Glu His 
545                 550                 555                 560 


Ile Glu Gln Gln Ile Gln Thr Tyr Gln Arg Ser Trp Leu Lys Val Thr 
                565                 570                 575     


Asp Tyr Ile Ala Glu Lys Asn Leu Pro Val Phe Gln Pro Gly Val Lys 
            580                 585                 590         


Leu Arg Asp Lys Glu Arg Gln Ile Ile Lys Glu Arg Phe Lys Gly Phe 
        595                 600                 605             


Asn Asp Gly Leu Glu Glu Leu Cys Lys Ile Gln Lys Ala Trp Ala Ile 
    610                 615                 620                 


Pro Asp Thr Glu Gln Arg Asp Arg Ile Arg Gln Ala Gln Lys Thr Ile 
625                 630                 635                 640 


Val Lys Glu Thr Tyr Gly Ala Phe Leu Gln Lys Phe Gly Ser Val Pro 
                645                 650                 655     


Phe Thr Lys Asn Pro Glu Lys Tyr Ile Lys Tyr Gly Val Glu Gln Val 
            660                 665                 670         


Gly Asp Met Ile Asp Arg Leu Phe Asp Thr Ser Ala 
        675                 680                 


<210>  3723
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOG__Homo_sapiens__NP_001138936

<400>  3723

Met Ala Ile Lys Ser Ile Ala Ser Arg Leu Arg Gly Ser Arg Arg Phe 
1               5                   10                  15      


Leu Ser Gly Phe Val Ala Gly Ala Val Val Gly Ala Ala Gly Ala Gly 
            20                  25                  30          


Leu Ala Ala Leu Gln Phe Phe Arg Ser Gln Gly Ala Glu Gly Ala Leu 
        35                  40                  45              


Thr Gly Lys Gln Pro Asp Gly Asp Ala Asp Arg Lys His Cys Lys Phe 
    50                  55                  60                  


Lys Pro Asp Pro Asn Ile Pro Pro Thr Phe Ser Ala Phe Asn Glu Asp 
65                  70                  75                  80  


Tyr Val Gly Ser Gly Trp Ser Arg Gly His Met Ala Pro Ala Gly Asn 
                85                  90                  95      


Asn Lys Phe Ser Ser Lys Ala Met Ala Glu Thr Phe Tyr Leu Ser Asn 
            100                 105                 110         


Ile Val Pro Gln Asp Phe Asp Asn Asn Ser Gly Tyr Trp Asn Arg Ile 
        115                 120                 125             


Glu Met Tyr Cys Arg Glu Leu Thr Glu Arg Phe Glu Asp Val Trp Val 
    130                 135                 140                 


Val Ser Gly Pro Leu Thr Leu Pro Gln Thr Arg Gly Asp Gly Lys Lys 
145                 150                 155                 160 


Ile Val Ser Tyr Gln Val Ile Gly Glu Asp Asn Val Ala Val Pro Ser 
                165                 170                 175     


His Leu Tyr Lys Val Ile Leu Ala Arg Arg Ser Ser Val Ser Thr Glu 
            180                 185                 190         


Pro Leu Ala Leu Gly Ala Phe Val Val Pro Asn Glu Ala Ile Gly Phe 
        195                 200                 205             


Gln Pro Gln Leu Thr Glu Phe Gln Val Ser Leu Gln Asp Leu Glu Lys 
    210                 215                 220                 


Leu Ser Gly Leu Val Phe Phe Pro His Leu Asp Arg Thr Ser Asp Ile 
225                 230                 235                 240 


Arg Asn Ile Cys Ser Val Asp Thr Cys Lys Leu Leu Asp Phe Gln Glu 
                245                 250                 255     


Phe Thr Leu Tyr Leu Ser Thr Arg Lys Ile Glu Gly Ala Arg Ser Val 
            260                 265                 270         


Leu Arg Leu Glu Lys Ile Met Glu Asn Leu Lys Asn Ala Glu Ile Glu 
        275                 280                 285             


Pro Asp Asp Tyr Phe Met Ser Arg Tyr Glu Lys Lys Leu Glu Glu Leu 
    290                 295                 300                 


Lys Ala Lys Glu Gln Ser Gly Thr Gln Ile Arg Lys Pro Ser 
305                 310                 315             


<210>  3724
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC1__Homo_sapiens__NP_057130

<400>  3724

Met Ala Pro Pro Val Arg Tyr Cys Ile Pro Gly Glu Arg Leu Cys Asn 
1               5                   10                  15      


Leu Glu Glu Gly Ser Pro Gly Ser Gly Thr Tyr Thr Arg His Gly Tyr 
            20                  25                  30          


Ile Phe Ser Ser Leu Ala Gly Cys Leu Met Lys Ser Ser Glu Asn Gly 
        35                  40                  45              


Ala Leu Pro Val Val Ser Val Val Arg Glu Thr Glu Ser Gln Leu Leu 
    50                  55                  60                  


Pro Asp Val Gly Ala Ile Val Thr Cys Lys Val Ser Ser Ile Asn Ser 
65                  70                  75                  80  


Arg Phe Ala Lys Val His Ile Leu Tyr Val Gly Ser Met Pro Leu Lys 
                85                  90                  95      


Asn Ser Phe Arg Gly Thr Ile Arg Lys Glu Asp Val Arg Ala Thr Glu 
            100                 105                 110         


Lys Asp Lys Val Glu Ile Tyr Lys Ser Phe Arg Pro Gly Asp Ile Val 
        115                 120                 125             


Leu Ala Lys Val Ile Ser Leu Gly Asp Ala Gln Ser Asn Tyr Leu Leu 
    130                 135                 140                 


Thr Thr Ala Glu Asn Glu Leu Gly Val Val Val Ala His Ser Glu Ser 
145                 150                 155                 160 


Gly Ile Gln Met Val Pro Ile Ser Trp Cys Glu Met Gln Cys Pro Lys 
                165                 170                 175     


Thr His Thr Lys Glu Phe Arg Lys Val Ala Arg Val Gln Pro Glu Phe 
            180                 185                 190         


Leu Gln Thr 
        195 


<210>  3725
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC2__Homo_sapiens__NP_001269637

<400>  3725

Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Gly Val 
    130                 135                 140                 


Leu Val Gln Val Ser Pro Ser Leu Val Lys Arg Gln Lys Thr His Phe 
145                 150                 155                 160 


His Asp Leu Pro Cys Gly Ala Ser Val Ile Leu Gly Asn Asn Gly Phe 
                165                 170                 175     


Ile Trp Ile Tyr Pro Thr Pro Glu His Lys Glu Glu Glu Ala Gly Gly 
            180                 185                 190         


Phe Ile Ala Asn Leu Glu Pro Val Ser Leu Ala Asp Arg Glu Val Ile 
        195                 200                 205             


Ser Arg Leu Arg Asn Cys Ile Ile Ser Leu Val Thr Gln Arg Met Met 
    210                 215                 220                 


Leu Tyr Asp Thr Ser Ile Leu Tyr Cys Tyr Glu Ala Ser Leu Pro His 
225                 230                 235                 240 


Gln Ile Lys Asp Ile Leu Lys Pro Glu Ile Met Glu Glu Ile Val Met 
                245                 250                 255     


Glu Thr Arg Gln Arg Leu Leu Glu Gln Glu Gly 
            260                 265         


<210>  3726
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC3__Homo_sapiens__NP_001002269

<400>  3726

Met Ala Glu Pro Ala Ser Val Ala Ala Glu Ser Leu Ala Gly Ser Arg 
1               5                   10                  15      


Ala Arg Ala Ala Arg Thr Val Leu Gly Gln Val Val Leu Pro Gly Glu 
            20                  25                  30          


Glu Leu Leu Leu Pro Glu Gln Glu Asp Ala Glu Gly Pro Gly Gly Ala 
        35                  40                  45              


Val Glu Arg Pro Leu Ser Leu Asn Ala Arg Ala Cys Ser Arg Val Arg 
    50                  55                  60                  


Val Val Cys Gly Pro Gly Leu Arg Arg Cys Gly Asp Arg Leu Leu Val 
65                  70                  75                  80  


Thr Lys Cys Gly Arg Leu Arg His Lys Glu Pro Gly Ser Gly Ser Gly 
                85                  90                  95      


Gly Gly Val Tyr Trp Val Asp Ser Gln Gln Lys Arg Tyr Val Pro Val 
            100                 105                 110         


Lys Gly Asp His Val Ile Gly Ile Val Thr Ala Lys Ser Gly Asp Ile 
        115                 120                 125             


Phe Lys Val Asp Val Gly Gly Ser Glu Pro Ala Ser Leu Ser Tyr Leu 
    130                 135                 140                 


Ser Phe Glu Gly Ala Thr Lys Arg Asn Arg Pro Asn Val Gln Ala Ile 
145                 150                 155                 160 


Ser Ser Arg Leu 
                


<210>  3727
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC4__Homo_sapiens__NP_061910

<400>  3727

Met Ala Gly Leu Glu Leu Leu Ser Asp Gln Gly Tyr Arg Val Asp Gly 
1               5                   10                  15      


Arg Arg Ala Gly Glu Leu Arg Lys Ile Gln Ala Arg Met Gly Val Phe 
            20                  25                  30          


Ala Gln Ala Asp Gly Ser Ala Tyr Ile Glu Gln Gly Asn Thr Lys Ala 
        35                  40                  45              


Leu Ala Val Val Tyr Gly Pro His Glu Ile Arg Gly Ser Arg Ala Arg 
    50                  55                  60                  


Ala Leu Pro Asp Arg Ala Leu Val Asn Cys Gln Tyr Ser Ser Ala Thr 
65                  70                  75                  80  


Phe Ser Thr Gly Glu Arg Lys Arg Arg Pro His Gly Asp Arg Lys Ser 
                85                  90                  95      


Cys Glu Met Gly Leu Gln Leu Arg Gln Thr Phe Glu Ala Ala Ile Leu 
            100                 105                 110         


Thr Gln Leu His Pro Arg Ser Gln Ile Asp Ile Tyr Val Gln Val Leu 
        115                 120                 125             


Gln Ala Asp Gly Gly Thr Tyr Ala Ala Cys Val Asn Ala Ala Thr Leu 
    130                 135                 140                 


Ala Val Leu Asp Ala Gly Ile Pro Met Arg Asp Phe Val Cys Ala Cys 
145                 150                 155                 160 


Ser Ala Gly Phe Val Asp Gly Thr Ala Leu Ala Asp Leu Ser His Val 
                165                 170                 175     


Glu Glu Ala Ala Gly Gly Pro Gln Leu Ala Leu Ala Leu Leu Pro Ala 
            180                 185                 190         


Ser Gly Gln Ile Ala Leu Leu Glu Met Asp Ala Arg Leu His Glu Asp 
        195                 200                 205             


His Leu Glu Arg Val Leu Glu Ala Ala Ala Gln Ala Ala Arg Asp Val 
    210                 215                 220                 


His Thr Leu Leu Asp Arg Val Val Arg Gln His Val Arg Glu Ala Ser 
225                 230                 235                 240 


Ile Leu Leu Gly Asp 
                245 


<210>  3728
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC5__Homo_sapiens__NP_064543

<400>  3728

Met Glu Glu Glu Thr His Thr Asp Ala Lys Ile Arg Ala Glu Asn Gly 
1               5                   10                  15      


Thr Gly Ser Ser Pro Arg Gly Pro Gly Cys Ser Leu Arg His Phe Ala 
            20                  25                  30          


Cys Glu Gln Asn Leu Leu Ser Arg Pro Asp Gly Ser Ala Ser Phe Leu 
        35                  40                  45              


Gln Gly Asp Thr Ser Val Leu Ala Gly Val Tyr Gly Pro Ala Glu Val 
    50                  55                  60                  


Lys Val Ser Lys Glu Ile Phe Asn Lys Ala Thr Leu Glu Val Ile Leu 
65                  70                  75                  80  


Arg Pro Lys Ile Gly Leu Pro Gly Val Ala Glu Lys Ser Arg Glu Arg 
                85                  90                  95      


Leu Ile Arg Asn Thr Cys Glu Ala Val Val Leu Gly Thr Leu His Pro 
            100                 105                 110         


Arg Thr Ser Ile Thr Val Val Leu Gln Val Val Ser Asp Ala Gly Ser 
        115                 120                 125             


Leu Leu Ala Cys Cys Leu Asn Ala Ala Cys Met Ala Leu Val Asp Ala 
    130                 135                 140                 


Gly Val Pro Met Arg Ala Leu Phe Cys Gly Val Ala Cys Ala Leu Asp 
145                 150                 155                 160 


Ser Asp Gly Thr Leu Val Leu Asp Pro Thr Ser Lys Gln Glu Lys Glu 
                165                 170                 175     


Ala Arg Ala Val Leu Thr Phe Ala Leu Asp Ser Val Glu Arg Lys Leu 
            180                 185                 190         


Leu Met Ser Ser Thr Lys Gly Leu Tyr Ser Asp Thr Glu Leu Gln Gln 
        195                 200                 205             


Cys Leu Ala Ala Ala Gln Ala Ala Ser Gln His Val Phe Arg Phe Tyr 
    210                 215                 220                 


Arg Glu Ser Leu Gln Arg Arg Tyr Ser Lys Ser 
225                 230                 235 


<210>  3729
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC6__Homo_sapiens__NP_478126

<400>  3729

Met Pro Gly Asp His Arg Arg Ile Arg Gly Pro Glu Glu Ser Gln Pro 
1               5                   10                  15      


Pro Gln Leu Tyr Ala Ala Asp Glu Glu Glu Ala Pro Gly Thr Arg Asp 
            20                  25                  30          


Pro Thr Arg Leu Arg Pro Val Tyr Ala Arg Ala Gly Leu Leu Ser Gln 
        35                  40                  45              


Ala Lys Gly Ser Ala Tyr Leu Glu Ala Gly Gly Thr Lys Val Leu Cys 
    50                  55                  60                  


Ala Val Ser Gly Pro Arg Gln Ala Glu Gly Gly Glu Arg Gly Gly Gly 
65                  70                  75                  80  


Pro Ala Gly Ala Gly Gly Glu Ala Pro Ala Ala Leu Arg Gly Arg Leu 
                85                  90                  95      


Leu Cys Asp Phe Arg Arg Ala Pro Phe Ala Gly Arg Arg Arg Arg Ala 
            100                 105                 110         


Pro Pro Gly Gly Cys Glu Glu Arg Glu Leu Ala Leu Ala Leu Gln Glu 
        115                 120                 125             


Ala Leu Glu Pro Ala Val Arg Leu Gly Arg Tyr Pro Arg Ala Gln Leu 
    130                 135                 140                 


Glu Val Ser Ala Leu Leu Leu Glu Asp Gly Gly Ser Ala Leu Ala Ala 
145                 150                 155                 160 


Ala Leu Thr Ala Ala Ala Leu Ala Leu Ala Asp Ala Gly Val Glu Met 
                165                 170                 175     


Tyr Asp Leu Val Val Gly Cys Gly Leu Ser Leu Ala Pro Gly Pro Ala 
            180                 185                 190         


Pro Thr Trp Leu Leu Asp Pro Thr Arg Leu Glu Glu Glu Arg Ala Ala 
        195                 200                 205             


Ala Gly Leu Thr Val Ala Leu Met Pro Val Leu Asn Gln Val Ala Gly 
    210                 215                 220                 


Leu Leu Gly Ser Gly Glu Gly Gly Leu Thr Glu Ser Trp Ala Glu Ala 
225                 230                 235                 240 


Val Arg Leu Gly Leu Glu Gly Cys Gln Arg Leu Tyr Pro Val Leu Gln 
                245                 250                 255     


Gln Ser Leu Val Arg Ala Ala Arg Arg Arg Gly Ala Ala Ala Gln Pro 
            260                 265                 270         


<210>  3730
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC7__Homo_sapiens__NP_055819

<400>  3730

Met Ala Ser Val Thr Leu Ser Glu Ala Glu Lys Val Tyr Ile Val His 
1               5                   10                  15      


Gly Val Gln Glu Asp Leu Arg Val Asp Gly Arg Gly Cys Glu Asp Tyr 
            20                  25                  30          


Arg Cys Val Glu Val Glu Thr Asp Val Val Ser Asn Thr Ser Gly Ser 
        35                  40                  45              


Ala Arg Val Lys Leu Gly His Thr Asp Ile Leu Val Gly Val Lys Ala 
    50                  55                  60                  


Glu Met Gly Thr Pro Lys Leu Glu Lys Pro Asn Glu Gly Tyr Leu Glu 
65                  70                  75                  80  


Phe Phe Val Asp Cys Ser Ala Ser Ala Thr Pro Glu Phe Glu Gly Arg 
                85                  90                  95      


Gly Gly Asp Asp Leu Gly Thr Glu Ile Ala Asn Thr Leu Tyr Arg Ile 
            100                 105                 110         


Phe Asn Asn Lys Ser Ser Val Asp Leu Lys Thr Leu Cys Ile Ser Pro 
        115                 120                 125             


Arg Glu His Cys Trp Val Leu Tyr Val Asp Val Leu Leu Leu Glu Cys 
    130                 135                 140                 


Gly Gly Asn Leu Phe Asp Ala Ile Ser Ile Ala Val Lys Ala Ala Leu 
145                 150                 155                 160 


Phe Asn Thr Arg Ile Pro Arg Val Arg Val Leu Glu Asp Glu Glu Gly 
                165                 170                 175     


Ser Lys Asp Ile Glu Leu Ser Asp Asp Pro Tyr Asp Cys Ile Arg Leu 
            180                 185                 190         


Ser Val Glu Asn Val Pro Cys Ile Val Thr Leu Cys Lys Ile Gly Tyr 
        195                 200                 205             


Arg His Val Val Asp Ala Thr Leu Gln Glu Glu Ala Cys Ser Leu Ala 
    210                 215                 220                 


Ser Leu Leu Val Ser Val Thr Ser Lys Gly Val Val Thr Cys Met Arg 
225                 230                 235                 240 


Lys Val Gly Lys Gly Ser Leu Asp Pro Glu Ser Ile Phe Glu Met Met 
                245                 250                 255     


Glu Thr Gly Lys Arg Val Gly Lys Val Leu His Ala Ser Leu Gln Ser 
            260                 265                 270         


Val Val His Lys Glu Glu Ser Leu Gly Pro Lys Arg Gln Lys Val Gly 
        275                 280                 285             


Phe Leu Gly 
    290     


<210>  3731
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXOSC8__Homo_sapiens__NP_852480

<400>  3731

Met Ala Ala Gly Phe Lys Thr Val Glu Pro Leu Glu Tyr Tyr Arg Arg 
1               5                   10                  15      


Phe Leu Lys Glu Asn Cys Arg Pro Asp Gly Arg Glu Leu Gly Glu Phe 
            20                  25                  30          


Arg Thr Thr Thr Val Asn Ile Gly Ser Ile Ser Thr Ala Asp Gly Ser 
        35                  40                  45              


Ala Leu Val Lys Leu Gly Asn Thr Thr Val Ile Cys Gly Val Lys Ala 
    50                  55                  60                  


Glu Phe Ala Ala Pro Ser Thr Asp Ala Pro Asp Lys Gly Tyr Val Val 
65                  70                  75                  80  


Pro Asn Val Asp Leu Pro Pro Leu Cys Ser Ser Arg Phe Arg Ser Gly 
                85                  90                  95      


Pro Pro Gly Glu Glu Ala Gln Val Ala Ser Gln Phe Ile Ala Asp Val 
            100                 105                 110         


Ile Glu Asn Ser Gln Ile Ile Gln Lys Glu Asp Leu Cys Ile Ser Pro 
        115                 120                 125             


Gly Lys Leu Val Trp Val Leu Tyr Cys Asp Leu Ile Cys Leu Asp Tyr 
    130                 135                 140                 


Asp Gly Asn Ile Leu Asp Ala Cys Thr Phe Ala Leu Leu Ala Ala Leu 
145                 150                 155                 160 


Lys Asn Val Gln Leu Pro Glu Val Thr Ile Asn Glu Glu Thr Ala Leu 
                165                 170                 175     


Ala Glu Val Asn Leu Lys Lys Lys Ser Tyr Leu Asn Ile Arg Thr His 
            180                 185                 190         


Pro Val Ala Thr Ser Phe Ala Val Phe Asp Asp Thr Leu Leu Ile Val 
        195                 200                 205             


Asp Pro Thr Gly Glu Glu Glu His Leu Ala Thr Gly Thr Leu Thr Ile 
    210                 215                 220                 


Val Met Asp Glu Glu Gly Lys Leu Cys Cys Leu His Lys Pro Gly Gly 
225                 230                 235                 240 


Ser Gly Leu Thr Gly Ala Lys Leu Gln Asp Cys Met Ser Arg Ala Val 
                245                 250                 255     


Thr Arg His Lys Glu Val Lys Lys Leu Met Asp Glu Val Ile Lys Ser 
            260                 265                 270         


Met Lys Pro Lys 
        275     


<210>  3732
<211>  1989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXPH5__Homo_sapiens__NP_055880

<400>  3732

Met Thr Lys Val Pro Pro Ala Phe Asp Phe Ser Phe Leu Asn Asp Glu 
1               5                   10                  15      


Glu Ala Arg Lys Ile Leu Gln Val Leu Glu Arg Asn Glu Glu Leu Gln 
            20                  25                  30          


Arg Ala Glu Lys Asp Arg Ile Ser Lys Leu Gln Lys Thr Lys Arg Asp 
        35                  40                  45              


Ile Arg Trp Leu Gln Gly Val Thr Gly Glu Trp Phe Glu Glu Ile Gln 
    50                  55                  60                  


Arg Lys Lys Phe Cys Asn Glu Thr Asp Val Ser Gln Met Leu Lys Gln 
65                  70                  75                  80  


Pro Leu Thr Tyr Arg Leu Ser Lys Glu Met Ala Lys Asn Asp Pro Ile 
                85                  90                  95      


Glu Leu Pro Thr Ser Arg Ser Lys Asn Val Thr Asn Gln Lys Lys Pro 
            100                 105                 110         


Thr Pro Phe Ser Ser Arg Met Ser Phe Arg Ser Ser Phe Ala Ser Leu 
        115                 120                 125             


Phe Ser Phe Arg Lys Ser Gly Lys Glu Thr Ser Lys Leu Pro Ser Leu 
    130                 135                 140                 


Gly Gln Lys Gly Cys Asp Gly His Ala Gly Pro Pro Met Pro Val Arg 
145                 150                 155                 160 


Gly Ala Ala Val Gln Ala Lys Ile Tyr Asn Ser Pro Leu Glu Asn His 
                165                 170                 175     


Leu Val Asp Ser Thr Phe Val Pro Lys Pro Ala Val Met Arg Glu Glu 
            180                 185                 190         


Ser Gly Met Pro Pro Pro Trp Asp Ala Ser Leu Leu Glu Asn Glu Phe 
        195                 200                 205             


Phe Gln Val Leu Asp Asp Leu Asp Ser Lys Leu Ala Gln Glu Gln Ser 
    210                 215                 220                 


Ala Ser Ser Val Asn Thr Arg Thr Pro Leu Asn Tyr Gly Ser Arg Thr 
225                 230                 235                 240 


Gln Phe Gly His Phe Tyr Ser Ser Gly Asn Arg His Gly Asn Ile Thr 
                245                 250                 255     


Glu Arg His Lys Lys His Tyr Asn Glu Thr Ser Asn Met Ser Ile Tyr 
            260                 265                 270         


Asp Ile Leu Arg Pro Gly Thr Pro Arg Glu Gly Phe Lys Thr Phe Ser 
        275                 280                 285             


Pro Arg Thr Ser Thr Ile Tyr Asp Met Tyr Arg Thr Arg Glu Pro Arg 
    290                 295                 300                 


Val Phe Lys Glu Asp Tyr Val Gln Lys Asn Thr Phe Gly Ser Thr Ser 
305                 310                 315                 320 


Leu Cys Phe Asp Ser Arg Gln Arg Ser Ala Leu Pro Ala Thr Gly His 
                325                 330                 335     


Phe Thr Ala Arg Ser Leu His Phe Pro Ala Thr Thr Gln Ser Lys Ser 
            340                 345                 350         


Gly Phe Ile Pro Pro Arg His Gln Gln Ser Pro Lys Arg Thr Pro Leu 
        355                 360                 365             


Ser Ser Ile Ile Trp Asn Arg Ser Asp Ser Ser Arg Asp Arg Glu Asn 
    370                 375                 380                 


Gln Glu Glu Phe Leu Arg Ala Pro Ser Pro Met Glu Ile Asp Pro Ala 
385                 390                 395                 400 


Asp Lys Tyr Val Tyr Pro Arg Gly Phe Gln Glu Asn Lys Arg Tyr Glu 
                405                 410                 415     


Ser Tyr His Ser Gln Asn Val Tyr Gln Arg Val Ser Leu Asn Ala Pro 
            420                 425                 430         


Met Glu Asn Ala Met Ser Pro Asp Thr Phe Glu Asn Ser Glu Asn Met 
        435                 440                 445             


Pro Phe Tyr His Gln Ser Asn Thr Phe Thr Arg Ser Phe Phe Ser Asn 
    450                 455                 460                 


Thr Phe Gly Arg Ser Gly Glu Gln Arg Arg Phe Gly Gln Gly Pro Phe 
465                 470                 475                 480 


Trp Gly Gln Glu Lys Gly His Ser Phe Trp Ser Asp Phe His Arg Ser 
                485                 490                 495     


Arg Lys Ser Phe Ser Ser Ser Asp Arg Asp Phe Glu Met Ile Ser Met 
            500                 505                 510         


Glu Ala Asn Ser Val Ser Ala Ile His Gly His Asn Val Ser Ser Glu 
        515                 520                 525             


His Trp Glu Ser Phe Ser Ser Gly Tyr Gly Thr Asp Val Ser Arg Gly 
    530                 535                 540                 


Gln Glu Glu Pro His Pro Trp Gln Phe Asp Phe Gln Arg Ser Thr Leu 
545                 550                 555                 560 


Asp Ser Met Val Val Ser His Gly Asn Glu Thr Gln Leu Thr Pro His 
                565                 570                 575     


Phe Gly Thr Pro Asn Val Cys Ser Met Thr Gly Ser Ser Tyr His Val 
            580                 585                 590         


Lys Ser Ser Glu Leu Val Ser Gln Gln Asp Ser Ser Pro Val Glu Val 
        595                 600                 605             


His Ile Asn Lys Glu Ala Ser Ser Phe Gly Ile Ala Gln Thr Leu Ala 
    610                 615                 620                 


Ser Ser Phe Lys Thr Ser Phe Ser Gln Ile Ser Asp Asp Arg Arg Asn 
625                 630                 635                 640 


Pro Gln Ser Pro Asn Leu Gln Asn Pro Thr Val Thr Leu Gln Lys Ile 
                645                 650                 655     


Phe Pro Asn Lys Pro Ala Ser His Pro Met Arg Ser His Thr Glu Val 
            660                 665                 670         


Thr Val Thr Ser Ser Asn Ser Val Asp Ser Leu Pro Leu Ala Lys Ser 
        675                 680                 685             


Gln Pro Asn Ile Leu Val Thr Glu Val Asn Asn Glu Lys Asp Leu Asn 
    690                 695                 700                 


Glu Ser Ile Ser Glu Glu Asp Lys Gln Leu Ser Lys Met Asp Gln Thr 
705                 710                 715                 720 


Asn Lys Ala Gly Glu Ile Pro Gln Pro Val Ser Gln Thr Gly Ile Ser 
                725                 730                 735     


Asn Ser Leu Pro Asp Phe Gln Asn Pro Leu Ser Gln Asp Ser Ala Lys 
            740                 745                 750         


Ser Asn Gly Phe Gly Phe Asn Ala Ser Thr Ile Ile Ser Ser Lys Lys 
        755                 760                 765             


Ser Pro Arg Val Phe Ser Arg Lys Asp Thr Ser Lys Met Tyr Ile Pro 
    770                 775                 780                 


His Thr Asp Lys Ser Asn Asp Ile Lys Gln Asp Lys Arg Phe Thr Glu 
785                 790                 795                 800 


Asn Arg Lys Leu Gly Ser Thr Ala Ser Leu Pro Phe Ile Gln Glu His 
                805                 810                 815     


Arg Thr Pro Pro Ser Phe Pro Arg Thr Asp Gln Gly Cys His Gln Glu 
            820                 825                 830         


Leu Thr Val Asn Asn Glu Asp Ile Ser Arg Ile Ile Thr Asn Asn His 
        835                 840                 845             


Trp Ser Ser Ala Leu Thr Asp Thr Gln Asn Ala Gln Tyr Ser Lys Cys 
    850                 855                 860                 


Lys Leu Thr Pro Gly His Lys Thr Ser Cys Asp Ser Leu Asp Leu Ser 
865                 870                 875                 880 


Ser Ala Ala Leu Pro Asp Ser Ser Pro Ser Lys Asn Ser Ser Leu Asp 
                885                 890                 895     


Ala Pro Val Val Pro Ser Thr Thr Val Phe Ser Arg Arg Ser Pro Ser 
            900                 905                 910         


Asp Lys Asp Pro Ser Leu Gly Glu Arg Glu Glu Lys Asp Asn Ala Gly 
        915                 920                 925             


Lys Asn Gln Lys Asn Gln Phe Ile Val Ser His Ser Glu Asn Gln Glu 
    930                 935                 940                 


Arg Asn Asp Ser Pro Val Pro Thr His Asp Glu Val Val Asp Val Lys 
945                 950                 955                 960 


Cys His Ser His Ser Pro Phe Arg Asn Glu Arg Gly Lys Gly Lys Ile 
                965                 970                 975     


Arg His His Ile Ser Cys Ile Glu Lys Leu Ser Lys Thr Glu Ser Ile 
            980                 985                 990         


Ser Val Pro Thr Ser Asp His Arg  Ser Leu Ile Glu Ala  Asn Gln Ser 
        995                 1000                 1005             


Asn Ser  Lys Val Ser Glu Leu  Asp Thr Ile Tyr Cys  Thr Leu Pro 
    1010                 1015                 1020             


Arg Lys  Ser Ser Ser Phe Leu  Ile His Gly Arg Gln  Ser Gly Ser 
    1025                 1030                 1035             


Lys Ile  Met Ala Ala Ser Leu  Arg Asn Gly Pro Pro  Pro Phe Gln 
    1040                 1045                 1050             


Ile Lys  Asn Asn Val Glu Asp  Ala Met Gly Asn Tyr  Met Leu Asn 
    1055                 1060                 1065             


Lys Phe  Ser Pro Ser Ser Pro  Glu Ser Ala Asn Glu  Cys Ser Lys 
    1070                 1075                 1080             


Val Leu  Ser Asp Ser Ala Leu  Glu Ala Pro Glu Ala  Thr Glu Arg 
    1085                 1090                 1095             


Met Thr  Asn Val Lys Ser Ser  Gly Ser Thr Ser Val  Arg Lys Gly 
    1100                 1105                 1110             


Pro Leu  Pro Phe Leu Ile Asn  Arg Ala Met Ser Cys  Pro Ser Gly 
    1115                 1120                 1125             


Glu Pro  His Ala Ser Thr Gly  Arg Glu Gly Arg Lys  Lys Pro Leu 
    1130                 1135                 1140             


Thr Ser  Gly Met Asp Ala Ser  Glu Leu Thr Pro Arg  Ala Trp Glu 
    1145                 1150                 1155             


Arg Ile  Ile Ser Pro Val Glu  Ser Asp Ser Ser Val  Arg Asp Cys 
    1160                 1165                 1170             


Ser Leu  Thr Lys Arg Gln His  Gln Lys Glu Asn Phe  Gln Glu Tyr 
    1175                 1180                 1185             


Thr Glu  Lys Glu Gly Lys Met  Ala Ala Ser Arg Arg  Ser Val Phe 
    1190                 1195                 1200             


Ala Leu  Ser Asn Glu Asp Pro  Leu Pro Phe Cys Ser  Asp Leu Ser 
    1205                 1210                 1215             


Gly Lys  Glu Arg Gly Lys Thr  Leu His Lys Val Lys  Thr Thr Ser 
    1220                 1225                 1230             


Thr Phe  Ser Val Ser Gly Asp  Glu Asp Asn Val Lys  Cys Leu Glu 
    1235                 1240                 1245             


Val Val  Ser Ile Tyr Tyr Thr  Leu Pro Arg Lys Pro  Ser Lys Lys 
    1250                 1255                 1260             


Phe Cys  Asn Leu Leu Gln Gln  Tyr Thr Gln Asn Thr  Asn Leu Leu 
    1265                 1270                 1275             


Ile Glu  Ser Pro Gln Val Glu  Thr Glu Thr Phe Pro  Asn Ala Leu 
    1280                 1285                 1290             


Glu Lys  Asp Lys Gln Asn Tyr  Ser Thr Arg Glu Gln  Ser Gly Thr 
    1295                 1300                 1305             


Pro Ser  Cys Glu Asn Leu Lys  Met Ser Val Asn Ser  Asp Gln Thr 
    1310                 1315                 1320             


Leu Thr  Thr Glu Asn Met Thr  Ala Phe Arg Leu Ser  Asn Arg Gly 
    1325                 1330                 1335             


Pro Leu  Ala Pro Thr Leu Gln  Glu Met Ala Ser Val  Glu Ala Ala 
    1340                 1345                 1350             


Val Ser  Leu Pro Glu Glu Glu  Ser Lys Ala Arg Glu  Ile Phe Ser 
    1355                 1360                 1365             


Asp Asn  Leu Ala Lys Thr Pro  Leu Gly Asp Ser Glu  Asn Lys Lys 
    1370                 1375                 1380             


Glu Arg  Gly Lys Lys Leu Gln  Ser Glu Thr Leu His  Thr Ser Leu 
    1385                 1390                 1395             


Met Leu  Gln Arg Lys Asn Val  Ser Glu Glu Lys Ser  Glu Asn Cys 
    1400                 1405                 1410             


Gln Gln  Ser Ile Asn Ser Ser  Asn Ser Gly Pro Ser  Ser Leu Pro 
    1415                 1420                 1425             


Ala Leu  Ser Glu Val Asn Ile  Gly Asn Ser Gln Thr  Arg Arg Ser 
    1430                 1435                 1440             


Ser Trp  Glu Cys Thr Gly Ser  Gly Arg Ala Ile Pro  Phe Thr Gly 
    1445                 1450                 1455             


Ser Gly  Lys Cys Pro Gln Lys  Asp His Thr Ser Thr  Ala Val Gly 
    1460                 1465                 1470             


Asp Gly  Ser Ser Gly Ser Gln  Pro Arg Glu Gly Arg  Gly Asp Ile 
    1475                 1480                 1485             


Gly Thr  Asn Cys Gln Lys Met  Thr Asn Lys Thr Leu  Ser His Ser 
    1490                 1495                 1500             


Glu Ser  Gln Val Phe Ala Leu  Thr Pro Ala Leu His  Lys Leu Gln 
    1505                 1510                 1515             


Leu Gly  Glu Glu Thr Gln Ser  Asp Glu Pro Asn Leu  Glu Ser Leu 
    1520                 1525                 1530             


Gln Ser  Glu Pro Arg Glu Leu  Pro Gln Arg Ser Gln  Glu Ala Asn 
    1535                 1540                 1545             


Met Thr  Glu Ser Arg Lys Ala  Glu Asp Glu Met Gln  Lys Ser Ala 
    1550                 1555                 1560             


Trp Asp  Gln Pro Ser Leu Pro  Glu Gly Asn Lys Asn  Lys Thr Asn 
    1565                 1570                 1575             


Leu Asp  Asp Leu Val Lys Gly  Glu Asn Arg Ser Ser  Val Lys His 
    1580                 1585                 1590             


Arg Leu  Ala Ala Met Ser Lys  Ala Ser Arg Lys Phe  Pro Ala Lys 
    1595                 1600                 1605             


Asp Val  Ser Pro Arg Arg His  Val Ala Thr Ile Phe  Pro Gln Ser 
    1610                 1615                 1620             


Gly Ser  Arg Ser Gly Phe Asp  His Leu Ser Leu Gly  Thr Val Glu 
    1625                 1630                 1635             


Cys Asn  Pro Leu Phe Pro Glu  Pro Thr Pro Lys Ser  Ala Glu Ser 
    1640                 1645                 1650             


Ile Gly  Glu Ser Arg Leu Ser  Glu Asn Gly Lys His  Val Lys Lys 
    1655                 1660                 1665             


Ser Glu  Asn Leu Leu Pro Ile  Thr Val Leu Pro Asn  Arg Glu Pro 
    1670                 1675                 1680             


Ser Thr  His Val Ser Asn Gln  Lys Ser Asn Ser Ile  Ser Gln Arg 
    1685                 1690                 1695             


His Gln  Asn Glu Phe Lys Asn  Val Ser Glu Ser Pro  Ser Lys His 
    1700                 1705                 1710             


Glu Asn  Ser Lys Asp Val Thr  Ala Ala Gln Asn Leu  Val Arg Glu 
    1715                 1720                 1725             


Ser Gly  Ala Pro Ser Pro Ile  Thr Phe Thr Ser Leu  Arg Glu Ala 
    1730                 1735                 1740             


Glu Phe  Ser Asp Asn Gln Arg  Arg Leu Ser Pro Pro  Phe Pro Leu 
    1745                 1750                 1755             


Glu Pro  Ala Gln Lys Ser Arg  Val Ser Ser Pro Leu  Ala Ser Phe 
    1760                 1765                 1770             


Leu Gln  Gln Gln Arg Ser Ala  Ser Ser Leu Glu Trp  Glu Pro Glu 
    1775                 1780                 1785             


Pro His  Leu Tyr Arg Ser Lys  Ser Leu Lys Ser Ile  Asn Val His 
    1790                 1795                 1800             


Gly Asp  Leu Leu Arg Lys Ser  His Pro Pro Lys Val  Arg Glu Arg 
    1805                 1810                 1815             


His Phe  Ser Glu Ser Thr Ser  Ile Asp Asn Ala Leu  Ser Arg Leu 
    1820                 1825                 1830             


Thr Leu  Gly Asn Glu Phe Ser  Val Asn Asn Gly Tyr  Ser Arg Arg 
    1835                 1840                 1845             


Phe Arg  Ser Phe Ser Glu Leu  Pro Ser Cys Asp Gly  Asn Glu Ser 
    1850                 1855                 1860             


Trp Ala  Tyr Arg Ser Gly Thr  Lys Thr Gly Pro Arg  Ser Ala Ile 
    1865                 1870                 1875             


Ser Ile  Tyr Arg Pro Ile Asp  Tyr Gly Ile Phe Gly  Lys Glu Gln 
    1880                 1885                 1890             


Gln Leu  Ala Phe Leu Glu Asn  Val Lys Arg Ser Leu  Thr Gln Gly 
    1895                 1900                 1905             


Arg Leu  Trp Lys Pro Ser Phe  Leu Lys Asn Pro Gly  Phe Leu Lys 
    1910                 1915                 1920             


Asp Asp  Leu Arg Asn Pro Pro  Asn Pro Ser Glu Ser  Leu Ser Ser 
    1925                 1930                 1935             


Asn Ser  Pro Ser Ser Gln Val  Pro Glu Asp Gly Leu  Ser Pro Ser 
    1940                 1945                 1950             


Glu Pro  Leu Asn Ile Tyr Glu  Asp Asp Pro Val Asp  Ser Asp Cys 
    1955                 1960                 1965             


Asp Thr  Asp Thr Thr Thr Asp  Asp Glu Tyr Tyr Leu  Asp Glu Asn 
    1970                 1975                 1980             


Asp Lys  Glu Ser Glu Leu 
    1985                 


<210>  3733
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXT1__Homo_sapiens__NP_000118

<400>  3733

Met Gln Ala Lys Lys Arg Tyr Phe Ile Leu Leu Ser Ala Gly Ser Cys 
1               5                   10                  15      


Leu Ala Leu Leu Phe Tyr Phe Gly Gly Leu Gln Phe Arg Ala Ser Arg 
            20                  25                  30          


Ser His Ser Arg Arg Glu Glu His Ser Gly Arg Asn Gly Leu His His 
        35                  40                  45              


Pro Ser Pro Asp His Phe Trp Pro Arg Phe Pro Asp Ala Leu Arg Pro 
    50                  55                  60                  


Phe Val Pro Trp Asp Gln Leu Glu Asn Glu Asp Ser Ser Val His Ile 
65                  70                  75                  80  


Ser Pro Arg Gln Lys Arg Asp Ala Asn Ser Ser Ile Tyr Lys Gly Lys 
                85                  90                  95      


Lys Cys Arg Met Glu Ser Cys Phe Asp Phe Thr Leu Cys Lys Lys Asn 
            100                 105                 110         


Gly Phe Lys Val Tyr Val Tyr Pro Gln Gln Lys Gly Glu Lys Ile Ala 
        115                 120                 125             


Glu Ser Tyr Gln Asn Ile Leu Ala Ala Ile Glu Gly Ser Arg Phe Tyr 
    130                 135                 140                 


Thr Ser Asp Pro Ser Gln Ala Cys Leu Phe Val Leu Ser Leu Asp Thr 
145                 150                 155                 160 


Leu Asp Arg Asp Gln Leu Ser Pro Gln Tyr Val His Asn Leu Arg Ser 
                165                 170                 175     


Lys Val Gln Ser Leu His Leu Trp Asn Asn Gly Arg Asn His Leu Ile 
            180                 185                 190         


Phe Asn Leu Tyr Ser Gly Thr Trp Pro Asp Tyr Thr Glu Asp Val Gly 
        195                 200                 205             


Phe Asp Ile Gly Gln Ala Met Leu Ala Lys Ala Ser Ile Ser Thr Glu 
    210                 215                 220                 


Asn Phe Arg Pro Asn Phe Asp Val Ser Ile Pro Leu Phe Ser Lys Asp 
225                 230                 235                 240 


His Pro Arg Thr Gly Gly Glu Arg Gly Phe Leu Lys Phe Asn Thr Ile 
                245                 250                 255     


Pro Pro Leu Arg Lys Tyr Met Leu Val Phe Lys Gly Lys Arg Tyr Leu 
            260                 265                 270         


Thr Gly Ile Gly Ser Asp Thr Arg Asn Ala Leu Tyr His Val His Asn 
        275                 280                 285             


Gly Glu Asp Val Val Leu Leu Thr Thr Cys Lys His Gly Lys Asp Trp 
    290                 295                 300                 


Gln Lys His Lys Asp Ser Arg Cys Asp Arg Asp Asn Thr Glu Tyr Glu 
305                 310                 315                 320 


Lys Tyr Asp Tyr Arg Glu Met Leu His Asn Ala Thr Phe Cys Leu Val 
                325                 330                 335     


Pro Arg Gly Arg Arg Leu Gly Ser Phe Arg Phe Leu Glu Ala Leu Gln 
            340                 345                 350         


Ala Ala Cys Val Pro Val Met Leu Ser Asn Gly Trp Glu Leu Pro Phe 
        355                 360                 365             


Ser Glu Val Ile Asn Trp Asn Gln Ala Ala Val Ile Gly Asp Glu Arg 
    370                 375                 380                 


Leu Leu Leu Gln Ile Pro Ser Thr Ile Arg Ser Ile His Gln Asp Lys 
385                 390                 395                 400 


Ile Leu Ala Leu Arg Gln Gln Thr Gln Phe Leu Trp Glu Ala Tyr Phe 
                405                 410                 415     


Ser Ser Val Glu Lys Ile Val Leu Thr Thr Leu Glu Ile Ile Gln Asp 
            420                 425                 430         


Arg Ile Phe Lys His Ile Ser Arg Asn Ser Leu Ile Trp Asn Lys His 
        435                 440                 445             


Pro Gly Gly Leu Phe Val Leu Pro Gln Tyr Ser Ser Tyr Leu Gly Asp 
    450                 455                 460                 


Phe Pro Tyr Tyr Tyr Ala Asn Leu Gly Leu Lys Pro Pro Ser Lys Phe 
465                 470                 475                 480 


Thr Ala Val Ile His Ala Val Thr Pro Leu Val Ser Gln Ser Gln Pro 
                485                 490                 495     


Val Leu Lys Leu Leu Val Ala Ala Ala Lys Ser Gln Tyr Cys Ala Gln 
            500                 505                 510         


Ile Ile Val Leu Trp Asn Cys Asp Lys Pro Leu Pro Ala Lys His Arg 
        515                 520                 525             


Trp Pro Ala Thr Ala Val Pro Val Val Val Ile Glu Gly Glu Ser Lys 
    530                 535                 540                 


Val Met Ser Ser Arg Phe Leu Pro Tyr Asp Asn Ile Ile Thr Asp Ala 
545                 550                 555                 560 


Val Leu Ser Leu Asp Glu Asp Thr Val Leu Ser Thr Thr Glu Val Asp 
                565                 570                 575     


Phe Ala Phe Thr Val Trp Gln Ser Phe Pro Glu Arg Ile Val Gly Tyr 
            580                 585                 590         


Pro Ala Arg Ser His Phe Trp Asp Asn Ser Lys Glu Arg Trp Gly Tyr 
        595                 600                 605             


Thr Ser Lys Trp Thr Asn Asp Tyr Ser Met Val Leu Thr Gly Ala Ala 
    610                 615                 620                 


Ile Tyr His Lys Tyr Tyr His Tyr Leu Tyr Ser His Tyr Leu Pro Ala 
625                 630                 635                 640 


Ser Leu Lys Asn Met Val Asp Gln Leu Ala Asn Cys Glu Asp Ile Leu 
                645                 650                 655     


Met Asn Phe Leu Val Ser Ala Val Thr Lys Leu Pro Pro Ile Lys Val 
            660                 665                 670         


Thr Gln Lys Lys Gln Tyr Lys Glu Thr Met Met Gly Gln Thr Ser Arg 
        675                 680                 685             


Ala Ser Arg Trp Ala Asp Pro Asp His Phe Ala Gln Arg Gln Ser Cys 
    690                 695                 700                 


Met Asn Thr Phe Ala Ser Trp Phe Gly Tyr Met Pro Leu Ile His Ser 
705                 710                 715                 720 


Gln Met Arg Leu Asp Pro Val Leu Phe Lys Asp Gln Val Ser Ile Leu 
                725                 730                 735     


Arg Lys Lys Tyr Arg Asp Ile Glu Arg Leu 
            740                 745     


<210>  3734
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXT2__Homo_sapiens__NP_000392

<400>  3734

Met Ser Cys Ala Ser Gly Ser Gly Gly Gly Leu Arg His Pro Leu Arg 
1               5                   10                  15      


Cys Gln Lys Pro Trp Asp Glu Glu Cys Glu Glu Glu Ala Val Cys Val 
            20                  25                  30          


Ile Met Cys Ala Ser Val Lys Tyr Asn Ile Arg Gly Pro Ala Leu Ile 
        35                  40                  45              


Pro Arg Met Lys Thr Lys His Arg Ile Tyr Tyr Ile Thr Leu Phe Ser 
    50                  55                  60                  


Ile Val Leu Leu Gly Leu Ile Ala Thr Gly Met Phe Gln Phe Trp Pro 
65                  70                  75                  80  


His Ser Ile Glu Ser Ser Asn Asp Trp Asn Val Glu Lys Arg Ser Ile 
                85                  90                  95      


Arg Asp Val Pro Val Val Arg Leu Pro Ala Asp Ser Pro Ile Pro Glu 
            100                 105                 110         


Arg Gly Asp Leu Ser Cys Arg Met His Thr Cys Phe Asp Val Tyr Arg 
        115                 120                 125             


Cys Gly Phe Asn Pro Lys Asn Lys Ile Lys Val Tyr Ile Tyr Ala Leu 
    130                 135                 140                 


Lys Lys Tyr Val Asp Asp Phe Gly Val Ser Val Ser Asn Thr Ile Ser 
145                 150                 155                 160 


Arg Glu Tyr Asn Glu Leu Leu Met Ala Ile Ser Asp Ser Asp Tyr Tyr 
                165                 170                 175     


Thr Asp Asp Ile Asn Arg Ala Cys Leu Phe Val Pro Ser Ile Asp Val 
            180                 185                 190         


Leu Asn Gln Asn Thr Leu Arg Ile Lys Glu Thr Ala Gln Ala Met Ala 
        195                 200                 205             


Gln Leu Ser Arg Trp Asp Arg Gly Thr Asn His Leu Leu Phe Asn Met 
    210                 215                 220                 


Leu Pro Gly Gly Pro Pro Asp Tyr Asn Thr Ala Leu Asp Val Pro Arg 
225                 230                 235                 240 


Asp Arg Ala Leu Leu Ala Gly Gly Gly Phe Ser Thr Trp Thr Tyr Arg 
                245                 250                 255     


Gln Gly Tyr Asp Val Ser Ile Pro Val Tyr Ser Pro Leu Ser Ala Glu 
            260                 265                 270         


Val Asp Leu Pro Glu Lys Gly Pro Gly Pro Arg Gln Tyr Phe Leu Leu 
        275                 280                 285             


Ser Ser Gln Val Gly Leu His Pro Glu Tyr Arg Glu Asp Leu Glu Ala 
    290                 295                 300                 


Leu Gln Val Lys His Gly Glu Ser Val Leu Val Leu Asp Lys Cys Thr 
305                 310                 315                 320 


Asn Leu Ser Glu Gly Val Leu Ser Val Arg Lys Arg Cys His Lys His 
                325                 330                 335     


Gln Val Phe Asp Tyr Pro Gln Val Leu Gln Glu Ala Thr Phe Cys Val 
            340                 345                 350         


Val Leu Arg Gly Ala Arg Leu Gly Gln Ala Val Leu Ser Asp Val Leu 
        355                 360                 365             


Gln Ala Gly Cys Val Pro Val Val Ile Ala Asp Ser Tyr Ile Leu Pro 
    370                 375                 380                 


Phe Ser Glu Val Leu Asp Trp Lys Arg Ala Ser Val Val Val Pro Glu 
385                 390                 395                 400 


Glu Lys Met Ser Asp Val Tyr Ser Ile Leu Gln Ser Ile Pro Gln Arg 
                405                 410                 415     


Gln Ile Glu Glu Met Gln Arg Gln Ala Arg Trp Phe Trp Glu Ala Tyr 
            420                 425                 430         


Phe Gln Ser Ile Lys Ala Ile Ala Leu Ala Thr Leu Gln Ile Ile Asn 
        435                 440                 445             


Asp Arg Ile Tyr Pro Tyr Ala Ala Ile Ser Tyr Glu Glu Trp Asn Asp 
    450                 455                 460                 


Pro Pro Ala Val Lys Trp Gly Ser Val Ser Asn Pro Leu Phe Leu Pro 
465                 470                 475                 480 


Leu Ile Pro Pro Gln Ser Gln Gly Phe Thr Ala Ile Val Leu Thr Tyr 
                485                 490                 495     


Asp Arg Val Glu Ser Leu Phe Arg Val Ile Thr Glu Val Ser Lys Val 
            500                 505                 510         


Pro Ser Leu Ser Lys Leu Leu Val Val Trp Asn Asn Gln Asn Lys Asn 
        515                 520                 525             


Pro Pro Glu Asp Ser Leu Trp Pro Lys Ile Arg Val Pro Leu Lys Val 
    530                 535                 540                 


Val Arg Thr Ala Glu Asn Lys Leu Ser Asn Arg Phe Phe Pro Tyr Asp 
545                 550                 555                 560 


Glu Ile Glu Thr Glu Ala Val Leu Ala Ile Asp Asp Asp Ile Ile Met 
                565                 570                 575     


Leu Thr Ser Asp Glu Leu Gln Phe Gly Tyr Glu Val Trp Arg Glu Phe 
            580                 585                 590         


Pro Asp Arg Leu Val Gly Tyr Pro Gly Arg Leu His Leu Trp Asp His 
        595                 600                 605             


Glu Met Asn Lys Trp Lys Tyr Glu Ser Glu Trp Thr Asn Glu Val Ser 
    610                 615                 620                 


Met Val Leu Thr Gly Ala Ala Phe Tyr His Lys Tyr Phe Asn Tyr Leu 
625                 630                 635                 640 


Tyr Thr Tyr Lys Met Pro Gly Asp Ile Lys Asn Trp Val Asp Ala His 
                645                 650                 655     


Met Asn Cys Glu Asp Ile Ala Met Asn Phe Leu Val Ala Asn Val Thr 
            660                 665                 670         


Gly Lys Ala Val Ile Lys Val Thr Pro Arg Lys Lys Phe Lys Cys Pro 
        675                 680                 685             


Glu Cys Thr Ala Ile Asp Gly Leu Ser Leu Asp Gln Thr His Met Val 
    690                 695                 700                 


Glu Arg Ser Glu Cys Ile Asn Lys Phe Ala Ser Val Phe Gly Thr Met 
705                 710                 715                 720 


Pro Leu Lys Val Val Glu His Arg Ala Asp Pro Val Leu Tyr Lys Asp 
                725                 730                 735     


Asp Phe Pro Glu Lys Leu Lys Ser Phe Pro Asn Ile Gly Ser Leu 
            740                 745                 750     


<210>  3735
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXTL2__Homo_sapiens__XP_011539298

<400>  3735

Met Arg Thr Trp Asn Ser Gly Gly Thr Lys Cys Cys His Ile Cys Lys 
1               5                   10                  15      


Leu Pro Gly Arg Val Met Gly Ile Arg Val Leu Arg Leu Ser Leu Val 
            20                  25                  30          


Val Ile Leu Val Leu Leu Leu Val Ala Gly Ala Leu Thr Ala Leu Leu 
        35                  40                  45              


Pro Ser Val Lys Glu Asp Lys Met Leu Met Leu Arg Arg Glu Ile Lys 
    50                  55                  60                  


Ser Gln Gly Lys Ser Thr Met Asp Ser Phe Thr Leu Ile Met Gln Thr 
65                  70                  75                  80  


Tyr Asn Arg Thr Asp Leu Leu Leu Lys Leu Leu Asn His Tyr Gln Ala 
                85                  90                  95      


Val Pro Asn Leu His Lys Val Ile Val Val Trp Asn Asn Ile Gly Glu 
            100                 105                 110         


Lys Ala Pro Asp Glu Leu Trp Asn Ser Leu Gly Pro His Pro Ile Pro 
        115                 120                 125             


Val Ile Phe Lys Gln Gln Thr Ala Asn Arg Met Arg Asn Arg Leu Gln 
    130                 135                 140                 


Val Phe Pro Glu Leu Glu Thr Asn Val Leu Met Val Asp Asp Asp Thr 
145                 150                 155                 160 


Leu Ile Ser Thr Pro Asp Leu Val Phe Ala Phe Ser Val Trp Gln Gln 
                165                 170                 175     


Phe Pro Asp Gln Ile Val Gly Phe Val Pro Arg Lys His Val Ser Thr 
            180                 185                 190         


Ser Ser Gly Ile Tyr Ser Tyr Gly Ser Phe Glu Met Gln Ala Pro Gly 
        195                 200                 205             


Ser Gly Asn Gly Asp Gln Tyr Ser Met Val Leu Ile Gly Ala Ser Phe 
    210                 215                 220                 


Phe Asn Ser Lys Tyr Leu Glu Leu Phe Gln Arg Gln Pro Ala Ala Val 
225                 230                 235                 240 


His Ala Leu Ile Asp Asp Thr Gln Asn Cys Asp Asp Ile Ala Met Asn 
                245                 250                 255     


Phe Ile Ile Ala Lys His Ile Gly Lys Thr Ser Gly Ile Phe Val Lys 
            260                 265                 270         


Pro Val Asn Met Asp Asn Leu Glu Lys Glu Thr Asn Ser Gly Tyr Ser 
        275                 280                 285             


Gly Met Trp His Arg Ala Glu His Ala Leu Gln Arg Ser Tyr Cys Ile 
    290                 295                 300                 


Asn Lys Leu Val Asn Ile Tyr Asp Ser Met Pro Leu Arg Tyr Ser Asn 
305                 310                 315                 320 


Ile Met Ile Ser Gln Phe Gly Phe Pro Tyr Ala Asn Tyr Lys Arg Lys 
                325                 330                 335     


Ile 
    


<210>  3736
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EXTL3__Homo_sapiens__NP_001431

<400>  3736

Met Thr Gly Tyr Thr Met Leu Arg Asn Gly Gly Ala Gly Asn Gly Gly 
1               5                   10                  15      


Gln Thr Cys Met Leu Arg Trp Ser Asn Arg Ile Arg Leu Thr Trp Leu 
            20                  25                  30          


Ser Phe Thr Leu Phe Val Ile Leu Val Phe Phe Pro Leu Ile Ala His 
        35                  40                  45              


Tyr Tyr Leu Thr Thr Leu Asp Glu Ala Asp Glu Ala Gly Lys Arg Ile 
    50                  55                  60                  


Phe Gly Pro Arg Val Gly Asn Glu Leu Cys Glu Val Lys His Val Leu 
65                  70                  75                  80  


Asp Leu Cys Arg Ile Arg Glu Ser Val Ser Glu Glu Leu Leu Gln Leu 
                85                  90                  95      


Glu Ala Lys Arg Gln Glu Leu Asn Ser Glu Ile Ala Lys Leu Asn Leu 
            100                 105                 110         


Lys Ile Glu Ala Cys Lys Lys Ser Ile Glu Asn Ala Lys Gln Asp Leu 
        115                 120                 125             


Leu Gln Leu Lys Asn Val Ile Ser Gln Thr Glu His Ser Tyr Lys Glu 
    130                 135                 140                 


Leu Met Ala Gln Asn Gln Pro Lys Leu Ser Leu Pro Ile Arg Leu Leu 
145                 150                 155                 160 


Pro Glu Lys Asp Asp Ala Gly Leu Pro Pro Pro Lys Ala Thr Arg Gly 
                165                 170                 175     


Cys Arg Leu His Asn Cys Phe Asp Tyr Ser Arg Cys Pro Leu Thr Ser 
            180                 185                 190         


Gly Phe Pro Val Tyr Val Tyr Asp Ser Asp Gln Phe Val Phe Gly Ser 
        195                 200                 205             


Tyr Leu Asp Pro Leu Val Lys Gln Ala Phe Gln Ala Thr Ala Arg Ala 
    210                 215                 220                 


Asn Val Tyr Val Thr Glu Asn Ala Asp Ile Ala Cys Leu Tyr Val Ile 
225                 230                 235                 240 


Leu Val Gly Glu Met Gln Glu Pro Val Val Leu Arg Pro Ala Glu Leu 
                245                 250                 255     


Glu Lys Gln Leu Tyr Ser Leu Pro His Trp Arg Thr Asp Gly His Asn 
            260                 265                 270         


His Val Ile Ile Asn Leu Ser Arg Lys Ser Asp Thr Gln Asn Leu Leu 
        275                 280                 285             


Tyr Asn Val Ser Thr Gly Arg Ala Met Val Ala Gln Ser Thr Phe Tyr 
    290                 295                 300                 


Thr Val Gln Tyr Arg Pro Gly Phe Asp Leu Val Val Ser Pro Leu Val 
305                 310                 315                 320 


His Ala Met Ser Glu Pro Asn Phe Met Glu Ile Pro Pro Gln Val Pro 
                325                 330                 335     


Val Lys Arg Lys Tyr Leu Phe Thr Phe Gln Gly Glu Lys Ile Glu Ser 
            340                 345                 350         


Leu Arg Ser Ser Leu Gln Glu Ala Arg Ser Phe Glu Glu Glu Met Glu 
        355                 360                 365             


Gly Asp Pro Pro Ala Asp Tyr Asp Asp Arg Ile Ile Ala Thr Leu Lys 
    370                 375                 380                 


Ala Val Gln Asp Ser Lys Leu Asp Gln Val Leu Val Glu Phe Thr Cys 
385                 390                 395                 400 


Lys Asn Gln Pro Lys Pro Ser Leu Pro Thr Glu Trp Ala Leu Cys Gly 
                405                 410                 415     


Glu Arg Glu Asp Arg Leu Glu Leu Leu Lys Leu Ser Thr Phe Ala Leu 
            420                 425                 430         


Ile Ile Thr Pro Gly Asp Pro Arg Leu Val Ile Ser Ser Gly Cys Ala 
        435                 440                 445             


Thr Arg Leu Phe Glu Ala Leu Glu Val Gly Ala Val Pro Val Val Leu 
    450                 455                 460                 


Gly Glu Gln Val Gln Leu Pro Tyr Gln Asp Met Leu Gln Trp Asn Glu 
465                 470                 475                 480 


Ala Ala Leu Val Val Pro Lys Pro Arg Val Thr Glu Val His Phe Leu 
                485                 490                 495     


Leu Arg Ser Leu Ser Asp Ser Asp Leu Leu Ala Met Arg Arg Gln Gly 
            500                 505                 510         


Arg Phe Leu Trp Glu Thr Tyr Phe Ser Thr Ala Asp Ser Ile Phe Asn 
        515                 520                 525             


Thr Val Leu Ala Met Ile Arg Thr Arg Ile Gln Ile Pro Ala Ala Pro 
    530                 535                 540                 


Ile Arg Glu Glu Ala Ala Ala Glu Ile Pro His Arg Ser Gly Lys Ala 
545                 550                 555                 560 


Ala Gly Thr Asp Pro Asn Met Ala Asp Asn Gly Asp Leu Asp Leu Gly 
                565                 570                 575     


Pro Val Glu Thr Glu Pro Pro Tyr Ala Ser Pro Arg Tyr Leu Arg Asn 
            580                 585                 590         


Phe Thr Leu Thr Val Thr Asp Phe Tyr Arg Ser Trp Asn Cys Ala Pro 
        595                 600                 605             


Gly Pro Phe His Leu Phe Pro His Thr Pro Phe Asp Pro Val Leu Pro 
    610                 615                 620                 


Ser Glu Ala Lys Phe Leu Gly Ser Gly Thr Gly Phe Arg Pro Ile Gly 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Ser Gly Lys Glu Phe Gln Ala Ala Leu Gly Gly 
                645                 650                 655     


Asn Val Pro Arg Glu Gln Phe Thr Val Val Met Leu Thr Tyr Glu Arg 
            660                 665                 670         


Glu Glu Val Leu Met Asn Ser Leu Glu Arg Leu Asn Gly Leu Pro Tyr 
        675                 680                 685             


Leu Asn Lys Val Val Val Val Trp Asn Ser Pro Lys Leu Pro Ser Glu 
    690                 695                 700                 


Asp Leu Leu Trp Pro Asp Ile Gly Val Pro Ile Met Val Val Arg Thr 
705                 710                 715                 720 


Glu Lys Asn Ser Leu Asn Asn Arg Phe Leu Pro Trp Asn Glu Ile Glu 
                725                 730                 735     


Thr Glu Ala Ile Leu Ser Ile Asp Asp Asp Ala His Leu Arg His Asp 
            740                 745                 750         


Glu Ile Met Phe Gly Phe Arg Val Trp Arg Glu Ala Arg Asp Arg Ile 
        755                 760                 765             


Val Gly Phe Pro Gly Arg Tyr His Ala Trp Asp Ile Pro His Gln Ser 
    770                 775                 780                 


Trp Leu Tyr Asn Ser Asn Tyr Ser Cys Glu Leu Ser Met Val Leu Thr 
785                 790                 795                 800 


Gly Ala Ala Phe Phe His Lys Tyr Tyr Ala Tyr Leu Tyr Ser Tyr Val 
                805                 810                 815     


Met Pro Gln Ala Ile Arg Asp Met Val Asp Glu Tyr Ile Asn Cys Glu 
            820                 825                 830         


Asp Ile Ala Met Asn Phe Leu Val Ser His Ile Thr Arg Lys Pro Pro 
        835                 840                 845             


Ile Lys Val Thr Ser Arg Trp Thr Phe Arg Cys Pro Gly Cys Pro Gln 
    850                 855                 860                 


Ala Leu Ser His Asp Asp Ser His Phe His Glu Arg His Lys Cys Ile 
865                 870                 875                 880 


Asn Phe Phe Val Lys Val Tyr Gly Tyr Met Pro Leu Leu Tyr Thr Gln 
                885                 890                 895     


Phe Arg Val Asp Ser Val Leu Phe Lys Thr Arg Leu Pro His Asp Lys 
            900                 905                 910         


Thr Lys Cys Phe Lys Phe Ile 
        915                 


<210>  3737
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EYA1__Homo_sapiens__NP_000494

<400>  3737

Met Glu Met Gln Asp Leu Thr Ser Pro His Ser Arg Leu Ser Gly Ser 
1               5                   10                  15      


Ser Glu Ser Pro Ser Gly Pro Lys Leu Gly Asn Ser His Ile Asn Ser 
            20                  25                  30          


Asn Ser Met Thr Pro Asn Gly Thr Glu Val Lys Thr Glu Pro Met Ser 
        35                  40                  45              


Ser Ser Glu Thr Ala Ser Thr Thr Ala Asp Gly Ser Leu Asn Asn Phe 
    50                  55                  60                  


Ser Gly Ser Ala Ile Gly Ser Ser Ser Phe Ser Pro Arg Pro Thr His 
65                  70                  75                  80  


Gln Phe Ser Pro Pro Gln Ile Tyr Pro Ser Asn Arg Pro Tyr Pro His 
                85                  90                  95      


Ile Leu Pro Thr Pro Ser Ser Gln Thr Met Ala Ala Tyr Gly Gln Thr 
            100                 105                 110         


Gln Phe Thr Thr Gly Met Gln Gln Ala Thr Ala Tyr Ala Thr Tyr Pro 
        115                 120                 125             


Gln Pro Gly Gln Pro Tyr Gly Ile Ser Ser Tyr Gly Ala Leu Trp Ala 
    130                 135                 140                 


Gly Ile Lys Thr Glu Gly Gly Leu Ser Gln Ser Gln Ser Pro Gly Gln 
145                 150                 155                 160 


Thr Gly Phe Leu Ser Tyr Gly Thr Ser Phe Ser Thr Pro Gln Pro Gly 
                165                 170                 175     


Gln Ala Pro Tyr Ser Tyr Gln Met Gln Gly Ser Ser Phe Thr Thr Ser 
            180                 185                 190         


Ser Gly Ile Tyr Thr Gly Asn Asn Ser Leu Thr Asn Ser Ser Gly Phe 
        195                 200                 205             


Asn Ser Ser Gln Gln Asp Tyr Pro Ser Tyr Pro Ser Phe Gly Gln Gly 
    210                 215                 220                 


Gln Tyr Ala Gln Tyr Tyr Asn Ser Ser Pro Tyr Pro Ala His Tyr Met 
225                 230                 235                 240 


Thr Ser Ser Asn Thr Ser Pro Thr Thr Pro Ser Thr Asn Ala Thr Tyr 
                245                 250                 255     


Gln Leu Gln Glu Pro Pro Ser Gly Ile Thr Ser Gln Ala Val Thr Asp 
            260                 265                 270         


Pro Thr Ala Glu Tyr Ser Thr Ile His Ser Pro Ser Thr Pro Ile Lys 
        275                 280                 285             


Asp Ser Asp Ser Asp Arg Leu Arg Arg Gly Ser Asp Gly Lys Ser Arg 
    290                 295                 300                 


Gly Arg Gly Arg Arg Asn Asn Asn Pro Ser Pro Pro Pro Asp Ser Asp 
305                 310                 315                 320 


Leu Glu Arg Val Phe Ile Trp Asp Leu Asp Glu Thr Ile Ile Val Phe 
                325                 330                 335     


His Ser Leu Leu Thr Gly Ser Tyr Ala Asn Arg Tyr Gly Arg Asp Pro 
            340                 345                 350         


Pro Thr Ser Val Ser Leu Gly Leu Arg Met Glu Glu Met Ile Phe Asn 
        355                 360                 365             


Leu Ala Asp Thr His Leu Phe Phe Asn Asp Leu Glu Glu Cys Asp Gln 
    370                 375                 380                 


Val His Ile Asp Asp Val Ser Ser Asp Asp Asn Gly Gln Asp Leu Ser 
385                 390                 395                 400 


Thr Tyr Asn Phe Gly Thr Asp Gly Phe Pro Ala Ala Ala Thr Ser Ala 
                405                 410                 415     


Asn Leu Cys Leu Ala Thr Gly Val Arg Gly Gly Val Asp Trp Met Arg 
            420                 425                 430         


Lys Leu Ala Phe Arg Tyr Arg Arg Val Lys Glu Ile Tyr Asn Thr Tyr 
        435                 440                 445             


Lys Asn Asn Val Gly Gly Leu Leu Gly Pro Ala Lys Arg Glu Ala Trp 
    450                 455                 460                 


Leu Gln Leu Arg Ala Glu Ile Glu Ala Leu Thr Asp Ser Trp Leu Thr 
465                 470                 475                 480 


Leu Ala Leu Lys Ala Leu Ser Leu Ile His Ser Arg Thr Asn Cys Val 
                485                 490                 495     


Asn Ile Leu Val Thr Thr Thr Gln Leu Ile Pro Ala Leu Ala Lys Val 
            500                 505                 510         


Leu Leu Tyr Gly Leu Gly Ile Val Phe Pro Ile Glu Asn Ile Tyr Ser 
        515                 520                 525             


Ala Thr Lys Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Ile Gln Arg 
    530                 535                 540                 


Phe Gly Arg Lys Val Val Tyr Val Val Ile Gly Asp Gly Val Glu Glu 
545                 550                 555                 560 


Glu Gln Gly Ala Lys Lys His Ala Met Pro Phe Trp Arg Ile Ser Ser 
                565                 570                 575     


His Ser Asp Leu Met Ala Leu His His Ala Leu Glu Leu Glu Tyr Leu 
            580                 585                 590         


<210>  3738
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EYA2__Homo_sapiens__NP_005235

<400>  3738

Met Val Glu Leu Val Ile Ser Pro Ser Leu Thr Val Asn Ser Asp Cys 
1               5                   10                  15      


Leu Asp Lys Leu Lys Phe Asn Arg Ala Asp Ala Ala Val Trp Thr Leu 
            20                  25                  30          


Ser Asp Arg Gln Gly Ile Thr Lys Ser Ala Pro Leu Arg Val Ser Gln 
        35                  40                  45              


Leu Phe Ser Arg Ser Cys Pro Arg Val Leu Pro Arg Gln Pro Ser Thr 
    50                  55                  60                  


Ala Met Ala Ala Tyr Gly Gln Thr Gln Tyr Ser Ala Gly Ile Gln Gln 
65                  70                  75                  80  


Ala Thr Pro Tyr Thr Ala Tyr Pro Pro Pro Ala Gln Ala Tyr Gly Ile 
                85                  90                  95      


Pro Ser Tyr Ser Ile Lys Thr Glu Asp Ser Leu Asn His Ser Pro Gly 
            100                 105                 110         


Gln Ser Gly Phe Leu Ser Tyr Gly Ser Ser Phe Ser Thr Ser Pro Thr 
        115                 120                 125             


Gly Gln Ser Pro Tyr Thr Tyr Gln Met His Gly Thr Thr Gly Phe Tyr 
    130                 135                 140                 


Gln Gly Gly Asn Gly Leu Gly Asn Ala Ala Gly Phe Gly Ser Val His 
145                 150                 155                 160 


Gln Asp Tyr Pro Ser Tyr Pro Gly Phe Pro Gln Ser Gln Tyr Pro Gln 
                165                 170                 175     


Tyr Tyr Gly Ser Ser Tyr Asn Pro Pro Tyr Val Pro Ala Ser Ser Ile 
            180                 185                 190         


Cys Pro Ser Pro Leu Ser Thr Ser Thr Tyr Val Leu Gln Glu Ala Ser 
        195                 200                 205             


His Asn Val Pro Asn Gln Ser Ser Glu Ser Leu Ala Gly Glu Tyr Asn 
    210                 215                 220                 


Thr His Asn Gly Pro Ser Thr Pro Ala Lys Glu Gly Asp Thr Asp Arg 
225                 230                 235                 240 


Pro His Arg Ala Ser Asp Gly Lys Leu Arg Gly Arg Ser Lys Arg Ser 
                245                 250                 255     


Ser Asp Pro Ser Pro Ala Gly Asp Asn Glu Ile Glu Arg Val Phe Val 
            260                 265                 270         


Trp Asp Leu Asp Glu Thr Ile Ile Ile Phe His Ser Leu Leu Thr Gly 
        275                 280                 285             


Thr Phe Ala Ser Arg Tyr Gly Lys Asp Thr Thr Thr Ser Val Arg Ile 
    290                 295                 300                 


Gly Leu Met Met Glu Glu Met Ile Phe Asn Leu Ala Asp Thr His Leu 
305                 310                 315                 320 


Phe Phe Asn Asp Leu Glu Asp Cys Asp Gln Ile His Val Asp Asp Val 
                325                 330                 335     


Ser Ser Asp Asp Asn Gly Gln Asp Leu Ser Thr Tyr Asn Phe Ser Ala 
            340                 345                 350         


Asp Gly Phe His Ser Ser Ala Pro Gly Ala Asn Leu Cys Leu Gly Ser 
        355                 360                 365             


Gly Val His Gly Gly Val Asp Trp Met Arg Lys Leu Ala Phe Arg Tyr 
    370                 375                 380                 


Arg Arg Val Lys Glu Met Tyr Asn Thr Tyr Lys Asn Asn Val Gly Gly 
385                 390                 395                 400 


Leu Ile Gly Thr Pro Lys Arg Glu Thr Trp Leu Gln Leu Arg Ala Glu 
                405                 410                 415     


Leu Glu Ala Leu Thr Asp Leu Trp Leu Thr His Ser Leu Lys Ala Leu 
            420                 425                 430         


Asn Leu Ile Asn Ser Arg Pro Asn Cys Val Asn Val Leu Val Thr Thr 
        435                 440                 445             


Thr Gln Leu Ile Pro Ala Leu Ala Lys Val Leu Leu Tyr Gly Leu Gly 
    450                 455                 460                 


Ser Val Phe Pro Ile Glu Asn Ile Tyr Ser Ala Thr Lys Thr Gly Lys 
465                 470                 475                 480 


Glu Ser Cys Phe Glu Arg Ile Met Gln Arg Phe Gly Arg Lys Ala Val 
                485                 490                 495     


Tyr Val Val Ile Gly Asp Gly Val Glu Glu Glu Gln Gly Ala Lys Lys 
            500                 505                 510         


His Asn Met Pro Phe Trp Arg Ile Ser Cys His Ala Asp Leu Glu Ala 
        515                 520                 525             


Leu Arg His Ala Leu Glu Leu Glu Tyr Leu 
    530                 535             


<210>  3739
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EYA4__Homo_sapiens__NP_004091

<400>  3739

Met Glu Asp Ser Gln Asp Leu Asn Glu Gln Ser Val Lys Lys Thr Cys 
1               5                   10                  15      


Thr Glu Ser Asp Val Ser Gln Ser Gln Asn Ser Arg Ser Met Glu Met 
            20                  25                  30          


Gln Asp Leu Ala Ser Pro His Thr Leu Val Gly Gly Gly Asp Thr Pro 
        35                  40                  45              


Gly Ser Ser Lys Leu Glu Lys Ser Asn Leu Ser Ser Thr Ser Val Thr 
    50                  55                  60                  


Thr Asn Gly Thr Gly Gly Glu Asn Met Thr Val Leu Asn Thr Ala Asp 
65                  70                  75                  80  


Trp Leu Leu Ser Cys Asn Thr Pro Ser Ser Ala Thr Met Ser Leu Leu 
                85                  90                  95      


Ala Val Lys Thr Glu Pro Leu Asn Ser Ser Glu Thr Thr Ala Thr Thr 
            100                 105                 110         


Gly Asp Gly Ala Leu Asp Thr Phe Thr Gly Ser Val Ile Thr Ser Ser 
        115                 120                 125             


Gly Tyr Ser Pro Arg Ser Ala His Gln Tyr Ser Pro Gln Leu Tyr Pro 
    130                 135                 140                 


Ser Lys Pro Tyr Pro His Ile Leu Ser Thr Pro Ala Ala Gln Thr Met 
145                 150                 155                 160 


Ser Ala Tyr Ala Gly Gln Thr Gln Tyr Ser Gly Met Gln Gln Pro Ala 
                165                 170                 175     


Val Tyr Thr Ala Tyr Ser Gln Thr Gly Gln Pro Tyr Ser Leu Pro Thr 
            180                 185                 190         


Tyr Asp Leu Gly Val Met Leu Pro Ala Ile Lys Thr Glu Ser Gly Leu 
        195                 200                 205             


Ser Gln Thr Gln Ser Pro Leu Gln Ser Gly Cys Leu Ser Tyr Ser Pro 
    210                 215                 220                 


Gly Phe Ser Thr Pro Gln Pro Gly Gln Thr Pro Tyr Ser Tyr Gln Met 
225                 230                 235                 240 


Pro Gly Ser Ser Phe Ala Pro Ser Ser Thr Ile Tyr Ala Asn Asn Ser 
                245                 250                 255     


Val Ser Asn Ser Thr Asn Phe Ser Gly Ser Gln Gln Asp Tyr Pro Ser 
            260                 265                 270         


Tyr Thr Ala Phe Gly Gln Asn Gln Tyr Ala Gln Tyr Tyr Ser Ala Ser 
        275                 280                 285             


Thr Tyr Gly Ala Tyr Met Thr Ser Asn Asn Thr Ala Asp Gly Thr Pro 
    290                 295                 300                 


Ser Ser Thr Ser Thr Tyr Gln Leu Gln Glu Ser Leu Pro Gly Leu Thr 
305                 310                 315                 320 


Asn Gln Pro Gly Glu Phe Asp Thr Met Gln Ser Pro Ser Thr Pro Ile 
                325                 330                 335     


Lys Asp Leu Asp Glu Arg Thr Cys Arg Ser Ser Gly Ser Lys Ser Arg 
            340                 345                 350         


Gly Arg Gly Arg Lys Asn Asn Pro Ser Pro Pro Pro Asp Ser Asp Leu 
        355                 360                 365             


Glu Arg Val Phe Val Trp Asp Leu Asp Glu Thr Ile Ile Val Phe His 
    370                 375                 380                 


Ser Leu Leu Thr Gly Ser Tyr Ala Gln Lys Tyr Gly Lys Asp Pro Pro 
385                 390                 395                 400 


Met Ala Val Thr Leu Gly Leu Arg Met Glu Glu Met Ile Phe Asn Leu 
                405                 410                 415     


Ala Asp Thr His Leu Phe Phe Asn Asp Leu Glu Glu Cys Asp Gln Val 
            420                 425                 430         


His Ile Asp Asp Val Ser Ser Asp Asp Asn Gly Gln Asp Leu Ser Thr 
        435                 440                 445             


Tyr Ser Phe Ala Thr Asp Gly Phe His Ala Ala Ala Ser Ser Ala Asn 
    450                 455                 460                 


Leu Cys Leu Pro Thr Gly Val Arg Gly Gly Val Asp Trp Met Arg Lys 
465                 470                 475                 480 


Leu Ala Phe Arg Tyr Arg Arg Val Lys Glu Leu Tyr Asn Thr Tyr Lys 
                485                 490                 495     


Asn Asn Val Gly Gly Leu Leu Gly Pro Ala Lys Arg Asp Ala Trp Leu 
            500                 505                 510         


Gln Leu Arg Ala Glu Ile Glu Gly Leu Thr Asp Ser Trp Leu Thr Asn 
        515                 520                 525             


Ala Leu Lys Ser Leu Ser Ile Ile Ser Thr Arg Ser Asn Cys Ile Asn 
    530                 535                 540                 


Val Leu Val Thr Thr Thr Gln Leu Ile Pro Ala Leu Ala Lys Val Leu 
545                 550                 555                 560 


Leu Tyr Ser Leu Gly Gly Ala Phe Pro Ile Glu Asn Ile Tyr Ser Ala 
                565                 570                 575     


Thr Lys Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Met Gln Arg Phe 
            580                 585                 590         


Gly Arg Lys Val Val Tyr Val Val Ile Gly Asp Gly Val Glu Glu Glu 
        595                 600                 605             


Gln Ala Ala Lys Lys His Asn Met Pro Phe Trp Arg Ile Ser Ser His 
    610                 615                 620                 


Ser Asp Leu Leu Ala Leu His Gln Ala Leu Glu Leu Glu Tyr Leu 
625                 630                 635                 


<210>  3740
<211>  3144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EYS__Homo_sapiens__NP_001136272

<400>  3740

Met Thr Asp Lys Ser Ile Val Ile Leu Ser Leu Met Val Phe His Ser 
1               5                   10                  15      


Ser Phe Ile Asn Gly Lys Thr Cys Arg Arg Gln Leu Val Glu Glu Trp 
            20                  25                  30          


His Pro Gln Pro Ser Ser Tyr Val Val Asn Trp Thr Leu Thr Glu Asn 
        35                  40                  45              


Ile Cys Leu Asp Phe Tyr Arg Asp Cys Trp Phe Leu Gly Val Asn Thr 
    50                  55                  60                  


Lys Ile Asp Thr Ser Gly Asn Gln Ala Val Pro Gln Ile Cys Pro Leu 
65                  70                  75                  80  


Gln Ile Gln Leu Gly Asp Ile Leu Val Ile Ser Ser Glu Pro Ser Leu 
                85                  90                  95      


Gln Phe Pro Glu Ile Asn Leu Met Asn Val Ser Glu Thr Ser Phe Val 
            100                 105                 110         


Gly Cys Val Gln Asn Thr Thr Thr Glu Asp Gln Leu Leu Phe Gly Cys 
        115                 120                 125             


Arg Leu Lys Gly Met His Thr Val Asn Ser Lys Trp Leu Ser Val Gly 
    130                 135                 140                 


Thr His Tyr Phe Ile Thr Val Met Ala Ser Gly Pro Ser Pro Cys Pro 
145                 150                 155                 160 


Leu Gly Leu Arg Leu Asn Val Thr Val Lys Gln Gln Phe Cys Gln Glu 
                165                 170                 175     


Ser Leu Ser Ser Glu Phe Cys Ser Gly His Gly Lys Cys Leu Ser Glu 
            180                 185                 190         


Ala Trp Ser Lys Thr Tyr Ser Cys His Cys Gln Pro Pro Phe Ser Gly 
        195                 200                 205             


Lys Tyr Cys Gln Glu Leu Asp Ala Cys Ser Phe Lys Pro Cys Lys Asn 
    210                 215                 220                 


Asn Gly Ser Cys Ile Asn Lys Arg Glu Asn Trp Asp Glu Gln Ala Tyr 
225                 230                 235                 240 


Glu Cys Val Cys His Pro Pro Phe Thr Gly Lys Asn Cys Ser Glu Ile 
                245                 250                 255     


Ile Gly Gln Cys Gln Pro His Val Cys Phe His Gly Asn Cys Ser Asn 
            260                 265                 270         


Ile Thr Ser Asn Ser Phe Ile Cys Glu Cys Asp Glu Gln Phe Ser Gly 
        275                 280                 285             


Pro Phe Cys Glu Val Ser Ala Lys Pro Cys Val Ser Leu Leu Phe Trp 
    290                 295                 300                 


Lys Arg Gly Ile Cys Pro Asn Ser Ser Ser Ala Tyr Thr Tyr Glu Cys 
305                 310                 315                 320 


Pro Lys Gly Ser Ser Ser Gln Asn Gly Glu Thr Asp Val Ser Glu Phe 
                325                 330                 335     


Ser Leu Val Pro Cys Gln Asn Gly Thr Asp Cys Ile Lys Ile Ser Asn 
            340                 345                 350         


Asp Val Met Cys Ile Cys Ser Pro Ile Phe Thr Asp Leu Leu Cys Lys 
        355                 360                 365             


Ser Ile Gln Thr Ser Cys Glu Ser Phe Pro Leu Arg Asn Asn Ala Thr 
    370                 375                 380                 


Cys Lys Lys Cys Glu Lys Asp Tyr Pro Cys Ser Cys Ile Ser Gly Phe 
385                 390                 395                 400 


Thr Glu Lys Asn Cys Glu Lys Ala Ile Asp His Cys Lys Leu Leu Ser 
                405                 410                 415     


Ile Asn Cys Leu Asn Glu Glu Trp Cys Phe Asn Ile Ile Gly Arg Phe 
            420                 425                 430         


Lys Tyr Val Cys Ile Pro Gly Cys Thr Lys Asn Pro Cys Trp Phe Leu 
        435                 440                 445             


Lys Asn Val Tyr Leu Ile His Gln His Leu Cys Tyr Cys Gly Val Thr 
    450                 455                 460                 


Phe His Gly Ile Cys Gln Asp Lys Gly Pro Ala Gln Phe Glu Tyr Val 
465                 470                 475                 480 


Trp Gln Leu Gly Phe Ala Gly Ser Glu Gly Glu Lys Cys Gln Gly Val 
                485                 490                 495     


Ile Asp Ala Tyr Phe Phe Leu Ala Ala Asn Cys Thr Glu Asp Ala Thr 
            500                 505                 510         


Tyr Val Asn Asp Pro Glu Asp Asn Asn Ser Ser Cys Trp Phe Pro His 
        515                 520                 525             


Glu Gly Thr Lys Glu Ile Cys Ala Asn Gly Cys Ser Cys Leu Ser Glu 
    530                 535                 540                 


Glu Asp Ser Gln Glu Tyr Arg Tyr Leu Cys Phe Leu Arg Trp Ala Gly 
545                 550                 555                 560 


Asn Met Tyr Leu Glu Asn Thr Thr Asp Asp Gln Glu Asn Glu Cys Gln 
                565                 570                 575     


His Glu Ala Val Cys Lys Asp Glu Ile Asn Arg Pro Arg Cys Ser Cys 
            580                 585                 590         


Ser Leu Ser Tyr Ile Gly Arg Leu Cys Val Val Asn Val Asp Tyr Cys 
        595                 600                 605             


Leu Gly Asn His Ser Ile Ser Val His Gly Leu Cys Leu Ala Leu Ser 
    610                 615                 620                 


His Asn Cys Asn Cys Ser Gly Leu Gln Arg Tyr Glu Arg Asn Ile Cys 
625                 630                 635                 640 


Glu Ile Asp Thr Glu Asp Cys Lys Ser Ala Ser Cys Lys Asn Gly Thr 
                645                 650                 655     


Thr Ser Thr His Leu Arg Gly Tyr Phe Phe Arg Lys Cys Val Pro Gly 
            660                 665                 670         


Phe Lys Gly Thr Gln Cys Glu Ile Asp Ile Asp Glu Cys Ala Ser His 
        675                 680                 685             


Pro Cys Lys Asn Gly Ala Thr Cys Ile Asp Gln Pro Gly Asn Tyr Phe 
    690                 695                 700                 


Cys Gln Cys Val Pro Pro Phe Lys Val Val Asp Gly Phe Ser Cys Leu 
705                 710                 715                 720 


Cys Asn Pro Gly Tyr Val Gly Ile Arg Cys Glu Gln Asp Ile Asp Asp 
                725                 730                 735     


Cys Ile Leu Asn Ala Cys Glu His Asn Ser Thr Cys Lys Asp Leu His 
            740                 745                 750         


Leu Ser Tyr Gln Cys Val Cys Leu Ser Asp Trp Glu Gly Asn Phe Cys 
        755                 760                 765             


Glu Gln Glu Ser Asn Glu Cys Lys Met Asn Pro Cys Lys Asn Asn Ser 
    770                 775                 780                 


Thr Cys Thr Asp Leu Tyr Lys Ser Tyr Arg Cys Glu Cys Thr Ser Gly 
785                 790                 795                 800 


Trp Thr Gly Gln Asn Cys Ser Glu Glu Ile Asn Glu Cys Asp Ser Asp 
                805                 810                 815     


Pro Cys Met Asn Gly Gly Leu Cys His Glu Ser Thr Ile Pro Gly Gln 
            820                 825                 830         


Phe Val Cys Leu Cys Pro Pro Leu Tyr Thr Gly Gln Phe Cys His Gln 
        835                 840                 845             


Arg Tyr Asn Leu Cys Asp Leu Leu His Asn Pro Cys Arg Asn Asn Ser 
    850                 855                 860                 


Thr Cys Leu Ala Leu Val Asp Ala Asn Gln His Cys Ile Cys Arg Glu 
865                 870                 875                 880 


Glu Phe Glu Gly Lys Asn Cys Glu Ile Asp Val Lys Asp Cys Leu Phe 
                885                 890                 895     


Leu Ser Cys Gln Asp Tyr Gly Asp Cys Glu Asp Met Val Asn Asn Phe 
            900                 905                 910         


Arg Cys Ile Cys Arg Pro Gly Phe Ser Gly Ser Leu Cys Glu Ile Glu 
        915                 920                 925             


Ile Asn Glu Cys Ser Ser Glu Pro Cys Lys Asn Asn Gly Thr Cys Val 
    930                 935                 940                 


Asp Leu Thr Asn Arg Phe Phe Cys Asn Cys Glu Pro Glu Tyr His Gly 
945                 950                 955                 960 


Pro Phe Cys Glu Leu Asp Val Asn Lys Cys Lys Ile Ser Pro Cys Leu 
                965                 970                 975     


Asp Glu Glu Asn Cys Val Tyr Arg Thr Asp Gly Tyr Asn Cys Leu Cys 
            980                 985                 990         


Ala Pro Gly Tyr Thr Gly Ile Asn  Cys Glu Ile Asn Leu  Asp Glu Cys 
        995                 1000                 1005             


Leu Ser  Glu Pro Cys Leu His  Asp Gly Val Cys Ile  Asp Gly Ile 
    1010                 1015                 1020             


Asn His  Tyr Thr Cys Asp Cys  Lys Ser Gly Phe Phe  Gly Thr His 
    1025                 1030                 1035             


Cys Glu  Thr Asn Ala Asn Asp  Cys Leu Ser Asn Pro  Cys Leu His 
    1040                 1045                 1050             


Gly Arg  Cys Thr Glu Leu Ile  Asn Glu Tyr Pro Cys  Ser Cys Asp 
    1055                 1060                 1065             


Ala Asp  Gly Thr Ser Thr Gln  Cys Lys Ile Lys Ile  Asn Asp Cys 
    1070                 1075                 1080             


Thr Ser  Ile Pro Cys Met Asn  Glu Gly Phe Cys Gln  Lys Ser Ala 
    1085                 1090                 1095             


His Gly  Phe Thr Cys Ile Cys  Pro Arg Gly Tyr Thr  Gly Ala Tyr 
    1100                 1105                 1110             


Cys Glu  Lys Ser Ile Asp Asn  Cys Ala Glu Pro Glu  Leu Asn Ser 
    1115                 1120                 1125             


Val Ile  Cys Leu Asn Gly Gly  Ile Cys Val Asp Gly  Pro Gly His 
    1130                 1135                 1140             


Thr Phe  Asp Cys Arg Cys Leu  Pro Gly Phe Ser Gly  Gln Phe Cys 
    1145                 1150                 1155             


Glu Ile  Asn Ile Asn Glu Cys  Ser Ser Ser Pro Cys  Leu His Gly 
    1160                 1165                 1170             


Ala Asp  Cys Glu Asp His Ile  Asn Gly Tyr Val Cys  Lys Cys Gln 
    1175                 1180                 1185             


Pro Gly  Trp Ser Gly His His  Cys Glu Asn Glu Leu  Glu Cys Ile 
    1190                 1195                 1200             


Pro Asn  Ser Cys Val His Glu  Leu Cys Met Glu Asn  Glu Pro Gly 
    1205                 1210                 1215             


Ser Thr  Cys Leu Cys Thr Pro  Gly Phe Met Thr Cys  Ser Ile Gly 
    1220                 1225                 1230             


Leu Leu  Cys Gly Asp Glu Ile  Arg Arg Ile Thr Cys  Leu Thr Pro 
    1235                 1240                 1245             


Ile Phe  Gln Arg Thr Asp Pro  Ile Ser Thr Gln Thr  Tyr Thr Ile 
    1250                 1255                 1260             


Pro Pro  Ser Glu Thr Leu Val  Ser Ser Phe Pro Ser  Ile Lys Ala 
    1265                 1270                 1275             


Thr Arg  Ile Pro Ala Ile Met  Asp Thr Tyr Pro Val  Asp Gln Gly 
    1280                 1285                 1290             


Pro Lys  Gln Thr Gly Ile Val  Lys His Asp Ile Leu  Pro Thr Thr 
    1295                 1300                 1305             


Gly Leu  Ala Thr Leu Arg Ile  Ser Thr Pro Leu Glu  Ser Tyr Leu 
    1310                 1315                 1320             


Leu Gln  Glu Leu Ile Val Thr  Arg Glu Leu Ser Ala  Lys His Ser 
    1325                 1330                 1335             


Leu Leu  Ser Ser Ala Asp Val  Ser Ser Ser Arg Phe  Leu Asn Phe 
    1340                 1345                 1350             


Gly Ile  Arg Asp Pro Ala Gln  Ile Val Gln Asp Lys  Thr Ser Val 
    1355                 1360                 1365             


Ser His  Met Pro Ile Arg Thr  Ser Ala Ala Thr Leu  Gly Phe Phe 
    1370                 1375                 1380             


Phe Pro  Asp Arg Arg Ala Arg  Thr Pro Phe Ile Met  Ser Ser Leu 
    1385                 1390                 1395             


Met Ser  Asp Phe Ile Phe Pro  Thr Gln Ser Leu Leu  Phe Glu Asn 
    1400                 1405                 1410             


Cys Gln  Thr Val Ala Leu Ser  Ala Thr Pro Thr Thr  Ser Val Ile 
    1415                 1420                 1425             


Arg Ser  Ile Pro Gly Ala Asp  Ile Glu Leu Asn Arg  Gln Ser Leu 
    1430                 1435                 1440             


Leu Ser  Arg Gly Phe Leu Leu  Ile Ala Ala Ser Ile  Ser Ala Thr 
    1445                 1450                 1455             


Pro Val  Val Ser Arg Gly Ala  Gln Glu Asp Ile Glu  Glu Tyr Ser 
    1460                 1465                 1470             


Ala Asp  Ser Leu Ile Ser Arg  Arg Glu His Trp Arg  Leu Leu Ser 
    1475                 1480                 1485             


Pro Ser  Met Ser Pro Ile Phe  Pro Ala Lys Val Ile  Ile Ser Lys 
    1490                 1495                 1500             


Gln Val  Thr Ile Leu Asn Ser  Ser Ala Leu His Arg  Phe Ser Thr 
    1505                 1510                 1515             


Lys Ala  Phe Asn Pro Ser Glu  Tyr Gln Ala Ile Thr  Glu Ala Ser 
    1520                 1525                 1530             


Ser Asn  Gln Arg Leu Thr Asn  Ile Lys Ser Gln Ala  Ala Asp Ser 
    1535                 1540                 1545             


Leu Arg  Glu Leu Ser Gln Thr  Cys Ala Thr Cys Ser  Met Thr Glu 
    1550                 1555                 1560             


Ile Lys  Ser Ser Arg Glu Phe  Ser Asp Gln Val Leu  His Ser Lys 
    1565                 1570                 1575             


Gln Ser  His Phe Tyr Glu Thr  Phe Trp Met Asn Ser  Ala Ile Leu 
    1580                 1585                 1590             


Ala Ser  Trp Tyr Ala Leu Met  Gly Ala Gln Thr Ile  Thr Ser Gly 
    1595                 1600                 1605             


His Ser  Phe Ser Ser Ala Thr  Glu Ile Thr Pro Ser  Val Ala Phe 
    1610                 1615                 1620             


Thr Glu  Val Pro Ser Leu Phe  Pro Ser Lys Lys Ser  Ala Lys Arg 
    1625                 1630                 1635             


Thr Ile  Leu Ser Ser Ser Leu  Glu Glu Ser Ile Thr  Leu Ser Ser 
    1640                 1645                 1650             


Asn Leu  Asp Val Asn Leu Cys  Leu Asp Lys Thr Cys  Leu Ser Ile 
    1655                 1660                 1665             


Val Pro  Ser Gln Thr Ile Ser  Ser Asp Leu Met Asn  Ser Asp Leu 
    1670                 1675                 1680             


Thr Ser  Lys Met Thr Thr Asp  Glu Leu Ser Val Ser  Glu Asn Ile 
    1685                 1690                 1695             


Leu Lys  Leu Leu Lys Ile Arg  Gln Tyr Gly Ile Thr  Met Gly Pro 
    1700                 1705                 1710             


Thr Glu  Val Leu Asn Gln Glu  Ser Leu Leu Asp Met  Glu Lys Ser 
    1715                 1720                 1725             


Lys Gly  Ser His Thr Leu Phe  Lys Leu His Pro Ser  Asp Ser Ser 
    1730                 1735                 1740             


Leu Asp  Phe Glu Leu Asn Leu  Gln Ile Tyr Pro Asp  Val Thr Leu 
    1745                 1750                 1755             


Lys Thr  Tyr Ser Glu Ile Thr  His Ala Asn Asp Phe  Lys Asn Asn 
    1760                 1765                 1770             


Leu Pro  Pro Leu Thr Gly Ser  Val Pro Asp Phe Ser  Glu Val Thr 
    1775                 1780                 1785             


Thr Asn  Val Ala Phe Tyr Thr  Val Ser Ala Thr Pro  Ala Leu Ser 
    1790                 1795                 1800             


Ile Gln  Thr Ser Ser Ser Met  Ser Val Ile Arg Pro  Asp Trp Pro 
    1805                 1810                 1815             


Tyr Phe  Thr Asp Tyr Met Thr  Ser Leu Lys Lys Glu  Val Lys Thr 
    1820                 1825                 1830             


Ser Ser  Glu Trp Ser Lys Trp  Glu Leu Gln Pro Ser  Val Gln Tyr 
    1835                 1840                 1845             


Gln Glu  Phe Pro Thr Ala Ser  Arg His Leu Pro Phe  Thr Arg Ser 
    1850                 1855                 1860             


Leu Thr  Leu Ser Ser Leu Glu  Ser Ile Leu Ala Pro  Gln Arg Leu 
    1865                 1870                 1875             


Met Ile  Ser Asp Phe Ser Cys  Val Arg Tyr Tyr Gly  Asp Ser Tyr 
    1880                 1885                 1890             


Leu Glu  Phe Gln Asn Val Ala  Leu Asn Pro Gln Asn  Asn Ile Ser 
    1895                 1900                 1905             


Leu Glu  Phe Gln Thr Phe Ser  Ser Tyr Gly Leu Leu  Leu Tyr Val 
    1910                 1915                 1920             


Lys Gln  Asp Ser Asn Leu Val  Asp Gly Phe Phe Ile  Gln Leu Phe 
    1925                 1930                 1935             


Ile Glu  Asn Gly Thr Leu Lys  Tyr His Phe Tyr Cys  Pro Gly Glu 
    1940                 1945                 1950             


Ala Lys  Phe Lys Ser Ile Asn  Thr Thr Val Arg Val  Asp Asn Gly 
    1955                 1960                 1965             


Gln Lys  Tyr Thr Leu Leu Ile  Arg Gln Glu Leu Asp  Pro Cys Asn 
    1970                 1975                 1980             


Ala Glu  Leu Thr Ile Leu Gly  Arg Asn Thr Gln Ile  Cys Glu Ser 
    1985                 1990                 1995             


Ile Asn  His Val Leu Gly Lys  Pro Leu Pro Lys Ser  Gly Ser Val 
    2000                 2005                 2010             


Phe Ile  Gly Gly Phe Pro Asp  Leu His Gly Lys Ile  Gln Met Pro 
    2015                 2020                 2025             


Val Pro  Val Lys Asn Phe Thr  Gly Cys Ile Glu Val  Ile Glu Ile 
    2030                 2035                 2040             


Asn Asn  Trp Arg Ser Phe Ile  Pro Ser Lys Ala Val  Lys Asn Tyr 
    2045                 2050                 2055             


His Ile  Asn Asn Cys Arg Ser  Gln Gly Phe Met Leu  Ser Pro Thr 
    2060                 2065                 2070             


Ala Ser  Phe Val Asp Ala Ser  Asp Val Thr Gln Gly  Val Asp Thr 
    2075                 2080                 2085             


Met Trp  Thr Ser Val Ser Pro  Ser Val Ala Ala Pro  Ser Val Cys 
    2090                 2095                 2100             


Gln Gln  Asp Val Cys His Asn  Gly Gly Thr Cys His  Ala Ile Phe 
    2105                 2110                 2115             


Leu Ser  Ser Gly Ile Val Ser  Phe Gln Cys Asp Cys  Pro Leu His 
    2120                 2125                 2130             


Phe Thr  Gly Arg Phe Cys Glu  Lys Asp Ala Gly Leu  Phe Phe Pro 
    2135                 2140                 2145             


Ser Phe  Asn Gly Asn Ser Tyr  Leu Glu Leu Pro Phe  Leu Lys Phe 
    2150                 2155                 2160             


Val Leu  Glu Lys Glu His Asn  Arg Thr Val Thr Ile  Tyr Leu Thr 
    2165                 2170                 2175             


Ile Lys  Thr Asn Ser Leu Asn  Gly Thr Ile Leu Tyr  Ser Asn Gly 
    2180                 2185                 2190             


Asn Asn  Cys Gly Lys Gln Phe  Leu His Leu Phe Leu  Val Glu Gly 
    2195                 2200                 2205             


Arg Pro  Ser Val Lys Tyr Gly  Cys Gly Asn Ser Gln  Asn Ile Leu 
    2210                 2215                 2220             


Thr Val  Ser Ala Asn Tyr Ser  Ile Asn Thr Asn Ala  Phe Thr Pro 
    2225                 2230                 2235             


Ile Thr  Ile Arg Tyr Thr Thr  Pro Val Gly Ser Pro  Gly Val Val 
    2240                 2245                 2250             


Cys Met  Ile Glu Met Thr Ala  Asp Gly Lys Pro Pro  Val Gln Lys 
    2255                 2260                 2265             


Lys Asp  Thr Glu Ile Ser His  Ala Ser Gln Ala Tyr  Phe Glu Ser 
    2270                 2275                 2280             


Met Phe  Leu Gly His Ile Pro  Ala Asn Val Gln Ile  His Lys Lys 
    2285                 2290                 2295             


Ala Gly  Pro Val Tyr Gly Phe  Arg Gly Cys Ile Leu  Asp Leu Gln 
    2300                 2305                 2310             


Val Asn  Asn Lys Glu Phe Phe  Ile Ile Asp Glu Ala  Arg His Gly 
    2315                 2320                 2325             


Lys Asn  Ile Glu Asn Cys His  Val Pro Trp Cys Ala  His His Leu 
    2330                 2335                 2340             


Cys Arg  Asn Asn Gly Thr Cys  Ile Ser Asp Asn Glu  Asn Leu Phe 
    2345                 2350                 2355             


Cys Glu  Cys Pro Arg Leu Tyr  Ser Gly Lys Leu Cys  Gln Phe Ala 
    2360                 2365                 2370             


Ser Cys  Glu Asn Asn Pro Cys  Gly Asn Gly Ala Thr  Cys Val Pro 
    2375                 2380                 2385             


Lys Ser  Gly Thr Asp Ile Val  Cys Leu Cys Pro Tyr  Gly Arg Ser 
    2390                 2395                 2400             


Gly Pro  Leu Cys Thr Asp Ala  Ile Asn Ile Thr Gln  Pro Arg Phe 
    2405                 2410                 2415             


Ser Gly  Thr Asp Ala Phe Gly  Tyr Thr Ser Phe Leu  Ala Tyr Ser 
    2420                 2425                 2430             


Arg Ile  Ser Asp Ile Ser Phe  His Tyr Glu Phe His  Leu Lys Phe 
    2435                 2440                 2445             


Gln Leu  Ala Asn Asn His Ser  Ala Leu Gln Asn Asn  Leu Ile Phe 
    2450                 2455                 2460             


Phe Thr  Gly Gln Lys Gly His  Gly Leu Asn Gly Asp  Asp Phe Leu 
    2465                 2470                 2475             


Ala Val  Gly Leu Leu Asn Gly  Ser Val Val Tyr Ser  Tyr Asn Leu 
    2480                 2485                 2490             


Gly Ser  Gly Ile Ala Ser Ile  Arg Ser Glu Pro Leu  Asn Leu Ser 
    2495                 2500                 2505             


Leu Gly  Val His Thr Val His  Leu Gly Lys Phe Phe  Gln Glu Gly 
    2510                 2515                 2520             


Trp Leu  Lys Val Asp Asp His  Lys Asn Lys Ser Ile  Ile Ala Pro 
    2525                 2530                 2535             


Gly Arg  Leu Val Gly Leu Asn  Val Phe Ser Gln Phe  Tyr Val Gly 
    2540                 2545                 2550             


Gly Tyr  Ser Glu Tyr Thr Pro  Asp Leu Leu Pro Asn  Gly Ala Asp 
    2555                 2560                 2565             


Phe Lys  Asn Gly Phe Gln Gly  Cys Ile Phe Thr Leu  Gln Val Arg 
    2570                 2575                 2580             


Thr Glu  Lys Asp Gly His Phe  Arg Gly Leu Gly Asn  Pro Glu Gly 
    2585                 2590                 2595             


His Pro  Asn Ala Gly Arg Ser  Val Gly Gln Cys His  Ala Ser Pro 
    2600                 2605                 2610             


Cys Ser  Leu Met Lys Cys Gly  Asn Gly Gly Thr Cys  Ile Glu Ser 
    2615                 2620                 2625             


Gly Thr  Ser Val Tyr Cys Asn  Cys Thr Thr Gly Trp  Lys Gly Ser 
    2630                 2635                 2640             


Phe Cys  Thr Glu Thr Val Ser  Thr Cys Asp Pro Glu  His Asp Pro 
    2645                 2650                 2655             


Pro His  His Cys Ser Arg Gly  Ala Thr Cys Ile Ser  Leu Pro His 
    2660                 2665                 2670             


Gly Tyr  Thr Cys Phe Cys Pro  Leu Gly Thr Thr Gly  Ile Tyr Cys 
    2675                 2680                 2685             


Glu Gln  Ala Leu Ser Ile Ser  Asp Pro Ser Phe Arg  Ser Asn Glu 
    2690                 2695                 2700             


Leu Ser  Trp Met Ser Phe Ala  Ser Phe His Val Arg  Lys Lys Thr 
    2705                 2710                 2715             


His Ile  Gln Leu Gln Phe Gln  Pro Leu Ala Ala Asp  Gly Ile Leu 
    2720                 2725                 2730             


Phe Tyr  Ala Ala Gln His Leu  Lys Ala Gln Ser Gly  Asp Phe Leu 
    2735                 2740                 2745             


Cys Ile  Ser Leu Val Asn Ser  Ser Val Gln Leu Arg  Tyr Asn Leu 
    2750                 2755                 2760             


Gly Asp  Arg Thr Ile Ile Leu  Glu Thr Leu Gln Lys  Val Thr Ile 
    2765                 2770                 2775             


Asn Gly  Ser Thr Trp His Ile  Ile Lys Ala Gly Arg  Val Gly Ala 
    2780                 2785                 2790             


Glu Gly  Tyr Leu Asp Leu Asp  Gly Ile Asn Val Thr  Glu Lys Ala 
    2795                 2800                 2805             


Ser Thr  Lys Met Ser Ser Leu  Asp Thr Asn Thr Asp  Phe Tyr Ile 
    2810                 2815                 2820             


Gly Gly  Val Ser Ser Leu Asn  Leu Val Asn Pro Met  Ala Ile Glu 
    2825                 2830                 2835             


Asn Glu  Pro Val Gly Phe Gln  Gly Cys Ile Arg Gln  Val Ile Ile 
    2840                 2845                 2850             


Asn Asn  Gln Glu Leu Gln Leu  Thr Glu Phe Gly Ala  Lys Gly Gly 
    2855                 2860                 2865             


Ser Asn  Val Gly Asp Cys Asp  Gly Thr Ala Cys Gly  Tyr Asn Thr 
    2870                 2875                 2880             


Cys Arg  Asn Gly Gly Glu Cys  Thr Val Asn Gly Thr  Thr Phe Ser 
    2885                 2890                 2895             


Cys Arg  Cys Leu Pro Asp Trp  Ala Gly Asn Thr Cys  Asn Gln Ser 
    2900                 2905                 2910             


Val Ser  Cys Leu Asn Asn Leu  Cys Leu His Gln Ser  Leu Cys Ile 
    2915                 2920                 2925             


Pro Asp  Gln Ser Phe Ser Tyr  Ser Cys Leu Cys Thr  Leu Gly Trp 
    2930                 2935                 2940             


Val Gly  Arg Tyr Cys Glu Asn  Lys Thr Ser Phe Ser  Thr Ala Lys 
    2945                 2950                 2955             


Phe Met  Gly Asn Ser Tyr Ile  Lys Tyr Ile Asp Pro  Asn Tyr Arg 
    2960                 2965                 2970             


Met Arg  Asn Leu Gln Phe Thr  Thr Ile Ser Leu Asn  Phe Ser Thr 
    2975                 2980                 2985             


Thr Lys  Thr Glu Gly Leu Ile  Val Trp Met Gly Ile  Ala Gln Asn 
    2990                 2995                 3000             


Glu Glu  Asn Asp Phe Leu Ala  Ile Gly Leu His Asn  Gln Thr Leu 
    3005                 3010                 3015             


Lys Ile  Ala Val Asn Leu Gly  Glu Arg Ile Ser Val  Pro Met Ser 
    3020                 3025                 3030             


Tyr Asn  Asn Gly Thr Phe Cys  Cys Asn Lys Trp His  His Val Val 
    3035                 3040                 3045             


Val Ile  Gln Asn Gln Thr Leu  Ile Lys Ala Tyr Ile  Asn Asn Ser 
    3050                 3055                 3060             


Leu Ile  Leu Ser Glu Asp Ile  Asp Pro His Lys Asn  Phe Val Ala 
    3065                 3070                 3075             


Leu Asn  Tyr Asp Gly Ile Cys  Tyr Leu Gly Gly Phe  Glu Tyr Gly 
    3080                 3085                 3090             


Arg Lys  Val Asn Ile Val Thr  Gln Glu Ile Phe Lys  Thr Asn Phe 
    3095                 3100                 3105             


Val Gly  Lys Ile Lys Asp Val  Val Phe Phe Gln Glu  Pro Lys Asn 
    3110                 3115                 3120             


Ile Glu  Leu Ile Lys Leu Glu  Gly Tyr Asn Val Tyr  Asp Gly Asp 
    3125                 3130                 3135             


Glu Gln  Asn Glu Val Thr 
    3140                 


<210>  3741
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EZH1__Homo_sapiens__NP_001982

<400>  3741

Met Glu Ile Pro Asn Pro Pro Thr Ser Lys Cys Ile Thr Tyr Trp Lys 
1               5                   10                  15      


Arg Lys Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Leu 
            20                  25                  30          


Gln Ala Asn Met Gly Ala Lys Ala Leu Tyr Val Ala Asn Phe Ala Lys 
        35                  40                  45              


Val Gln Glu Lys Thr Gln Ile Leu Asn Glu Glu Trp Lys Lys Leu Arg 
    50                  55                  60                  


Val Gln Pro Val Gln Ser Met Lys Pro Val Ser Gly His Pro Phe Leu 
65                  70                  75                  80  


Lys Lys Cys Thr Ile Glu Ser Ile Phe Pro Gly Phe Ala Ser Gln His 
                85                  90                  95      


Met Leu Met Arg Ser Leu Asn Thr Val Ala Leu Val Pro Ile Met Tyr 
            100                 105                 110         


Ser Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val 
        115                 120                 125             


Leu Cys Asn Ile Pro Tyr Met Gly Asp Glu Val Lys Glu Glu Asp Glu 
    130                 135                 140                 


Thr Phe Ile Glu Glu Leu Ile Asn Asn Tyr Asp Gly Lys Val His Gly 
145                 150                 155                 160 


Glu Glu Glu Met Ile Pro Gly Ser Val Leu Ile Ser Asp Ala Val Phe 
                165                 170                 175     


Leu Glu Leu Val Asp Ala Leu Asn Gln Tyr Ser Asp Glu Glu Glu Glu 
            180                 185                 190         


Gly His Asn Asp Thr Ser Asp Gly Lys Gln Asp Asp Ser Lys Glu Asp 
        195                 200                 205             


Leu Pro Val Thr Arg Lys Arg Lys Arg His Ala Ile Glu Gly Asn Lys 
    210                 215                 220                 


Lys Ser Ser Lys Lys Gln Phe Pro Asn Asp Met Ile Phe Ser Ala Ile 
225                 230                 235                 240 


Ala Ser Met Phe Pro Glu Asn Gly Val Pro Asp Asp Met Lys Glu Arg 
                245                 250                 255     


Tyr Arg Glu Leu Thr Glu Met Ser Asp Pro Asn Ala Leu Pro Pro Gln 
            260                 265                 270         


Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu 
        275                 280                 285             


Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys 
    290                 295                 300                 


Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn Val Tyr Lys 
305                 310                 315                 320 


Arg Lys Asn Lys Glu Ile Lys Ile Glu Pro Glu Pro Cys Gly Thr Asp 
                325                 330                 335     


Cys Phe Leu Leu Leu Glu Gly Ala Lys Glu Tyr Ala Met Leu His Asn 
            340                 345                 350         


Pro Arg Ser Lys Cys Ser Gly Arg Arg Arg Arg Arg His His Ile Val 
        355                 360                 365             


Ser Ala Ser Cys Ser Asn Ala Ser Ala Ser Ala Val Ala Glu Thr Lys 
    370                 375                 380                 


Glu Gly Asp Ser Asp Arg Asp Thr Gly Asn Asp Trp Ala Ser Ser Ser 
385                 390                 395                 400 


Ser Glu Ala Asn Ser Arg Cys Gln Thr Pro Thr Lys Gln Lys Ala Ser 
                405                 410                 415     


Pro Ala Pro Pro Gln Leu Cys Val Val Glu Ala Pro Ser Glu Pro Val 
            420                 425                 430         


Glu Trp Thr Gly Ala Glu Glu Ser Leu Phe Arg Val Phe His Gly Thr 
        435                 440                 445             


Tyr Phe Asn Asn Phe Cys Ser Ile Ala Arg Leu Leu Gly Thr Lys Thr 
    450                 455                 460                 


Cys Lys Gln Val Phe Gln Phe Ala Val Lys Glu Ser Leu Ile Leu Lys 
465                 470                 475                 480 


Leu Pro Thr Asp Glu Leu Met Asn Pro Ser Gln Lys Lys Lys Arg Lys 
                485                 490                 495     


His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp 
            500                 505                 510         


Asn Ser Ser Thr Gln Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Asp 
        515                 520                 525             


Arg Pro Cys Asp Ser Thr Cys Pro Cys Ile Met Thr Gln Asn Phe Cys 
    530                 535                 540                 


Glu Lys Phe Cys Gln Cys Asn Pro Asp Cys Gln Asn Arg Phe Pro Gly 
545                 550                 555                 560 


Cys Arg Cys Lys Thr Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu 
                565                 570                 575     


Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ser 
            580                 585                 590         


Glu His Trp Asp Cys Lys Val Val Ser Cys Lys Asn Cys Ser Ile Gln 
        595                 600                 605             


Arg Gly Leu Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly 
    610                 615                 620                 


Trp Gly Thr Phe Ile Lys Glu Ser Val Gln Lys Asn Glu Phe Ile Ser 
625                 630                 635                 640 


Glu Tyr Cys Gly Glu Leu Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly 
                645                 650                 655     


Lys Val Tyr Asp Lys Tyr Met Ser Ser Phe Leu Phe Asn Leu Asn Asn 
            660                 665                 670         


Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala 
        675                 680                 685             


Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Val Met Val Asn 
    690                 695                 700                 


Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Ala Gly 
705                 710                 715                 720 


Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys 
                725                 730                 735     


Tyr Val Gly Ile Glu Arg Glu Thr Asp Val Leu 
            740                 745         


<210>  3742
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EZH2__Homo_sapiens__XP_005250019

<400>  3742

Met Ile Tyr Phe Ile Arg Ile Ile Met Gly Gln Thr Gly Lys Lys Ser 
1               5                   10                  15      


Glu Lys Gly Pro Val Cys Trp Arg Lys Arg Val Lys Ser Glu Tyr Met 
            20                  25                  30          


Arg Leu Arg Gln Leu Lys Arg Phe Arg Arg Ala Asp Glu Val Lys Ser 
        35                  40                  45              


Met Phe Ser Ser Asn Arg Gln Lys Ile Leu Glu Arg Thr Glu Ile Leu 
    50                  55                  60                  


Asn Gln Glu Trp Lys Gln Arg Arg Ile Gln Pro Val His Ile Leu Thr 
65                  70                  75                  80  


Ser Val Ser Ser Leu Arg Gly Thr Arg Glu Cys Ser Val Thr Ser Asp 
                85                  90                  95      


Leu Asp Phe Pro Thr Gln Val Ile Pro Leu Lys Thr Leu Asn Ala Val 
            100                 105                 110         


Ala Ser Val Pro Ile Met Tyr Ser Trp Ser Pro Leu Gln Gln Asn Phe 
        115                 120                 125             


Met Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly Asp 
    130                 135                 140                 


Glu Val Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys Asn 
145                 150                 155                 160 


Tyr Asp Gly Lys Val His Gly Asp Arg Glu Cys Gly Phe Ile Asn Asp 
                165                 170                 175     


Glu Ile Phe Val Glu Leu Val Asn Ala Leu Gly Gln Tyr Asn Asp Asp 
            180                 185                 190         


Asp Asp Asp Asp Asp Gly Asp Asp Pro Glu Glu Arg Glu Glu Lys Gln 
        195                 200                 205             


Lys Asp Leu Glu Asp His Arg Asp Asp Lys Glu Ser Arg Pro Pro Arg 
    210                 215                 220                 


Lys Phe Pro Ser Asp Lys Ile Phe Glu Ala Ile Ser Ser Met Phe Pro 
225                 230                 235                 240 


Asp Lys Gly Thr Ala Glu Glu Leu Lys Glu Lys Tyr Lys Glu Leu Thr 
                245                 250                 255     


Glu Gln Gln Leu Pro Gly Ala Leu Pro Pro Glu Cys Thr Pro Asn Ile 
            260                 265                 270         


Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu Gln Ser Leu His Ser 
        275                 280                 285             


Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys Tyr Asp Cys Phe Leu 
    290                 295                 300                 


His Pro Phe His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu 
305                 310                 315                 320 


Thr Ala Leu Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu 
                325                 330                 335     


Glu Gly Ala Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys 
            340                 345                 350         


Thr Pro Pro Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn 
        355                 360                 365             


Asn Ser Ser Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys 
    370                 375                 380                 


Asp Thr Asp Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn 
385                 390                 395                 400 


Asn Asp Lys Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser 
                405                 410                 415     


Glu Ala Asn Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile 
            420                 425                 430         


Glu Pro Pro Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe 
        435                 440                 445             


Arg Val Leu Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg 
    450                 455                 460                 


Leu Ile Gly Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val Lys 
465                 470                 475                 480 


Glu Ser Ser Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr Pro 
                485                 490                 495     


Pro Arg Lys Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys Arg 
            500                 505                 510         


Lys Ile Gln Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn Tyr 
        515                 520                 525             


Gln Pro Cys Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro Cys 
    530                 535                 540                 


Val Ile Ala Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser Glu 
545                 550                 555                 560 


Cys Gln Asn Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn Thr 
                565                 570                 575     


Lys Gln Cys Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp Leu 
            580                 585                 590         


Cys Leu Thr Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val Ser 
        595                 600                 605             


Cys Lys Asn Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu Leu 
    610                 615                 620                 


Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val 
625                 630                 635                 640 


Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln 
                645                 650                 655     


Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys Ser 
            660                 665                 670         


Phe Leu Phe Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg Lys 
        675                 680                 685             


Gly Asn Lys Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys Tyr 
    690                 695                 700                 


Ala Lys Val Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe Ala 
705                 710                 715                 720 


Lys Arg Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg Tyr 
                725                 730                 735     


Ser Gln Ala Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met Glu 
            740                 745                 750         


Ile Pro 
        


<210>  3743
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EZR__Homo_sapiens__NP_001104547

<400>  3743

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu 
                325                 330                 335     


Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln 
            340                 345                 350         


Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln 
        355                 360                 365             


Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys 
385                 390                 395                 400 


Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg 
        435                 440                 445             


Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His 
    450                 455                 460                 


Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro 
465                 470                 475                 480 


Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro 
                485                 490                 495     


Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg 
            500                 505                 510         


Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln 
        515                 520                 525             


Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu 
    530                 535                 540                 


Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln 
545                 550                 555                 560 


Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr 
                565                 570                 575     


Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu 
            580                 585     


<210>  3744
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F10__Homo_sapiens__NP_000495

<400>  3744

Met Gly Arg Pro Leu His Leu Val Leu Leu Ser Ala Ser Leu Ala Gly 
1               5                   10                  15      


Leu Leu Leu Leu Gly Glu Ser Leu Phe Ile Arg Arg Glu Gln Ala Asn 
            20                  25                  30          


Asn Ile Leu Ala Arg Val Thr Arg Ala Asn Ser Phe Leu Glu Glu Met 
        35                  40                  45              


Lys Lys Gly His Leu Glu Arg Glu Cys Met Glu Glu Thr Cys Ser Tyr 
    50                  55                  60                  


Glu Glu Ala Arg Glu Val Phe Glu Asp Ser Asp Lys Thr Asn Glu Phe 
65                  70                  75                  80  


Trp Asn Lys Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln 
                85                  90                  95      


Asn Gln Gly Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys 
            100                 105                 110         


Leu Glu Gly Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu 
        115                 120                 125             


Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln 
    130                 135                 140                 


Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr 
                165                 170                 175     


Leu Glu Arg Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly 
            180                 185                 190         


Glu Ala Pro Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu 
        195                 200                 205             


Asp Pro Thr Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln 
    210                 215                 220                 


Pro Glu Arg Gly Asp Asn Asn Leu Thr Arg Ile Val Gly Gly Gln Glu 
225                 230                 235                 240 


Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile Asn Glu Glu 
                245                 250                 255     


Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe Tyr Ile Leu 
            260                 265                 270         


Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys Val Arg Val 
        275                 280                 285             


Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala Val His Glu 
    290                 295                 300                 


Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu Thr Tyr Asp 
305                 310                 315                 320 


Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr Phe Arg Met 
                325                 330                 335     


Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala Glu Ser Thr 
            340                 345                 350         


Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly Arg Thr His 
        355                 360                 365             


Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu Val Pro Tyr 
    370                 375                 380                 


Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile Ile Thr Gln 
385                 390                 395                 400 


Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp Ala Cys Gln 
                405                 410                 415     


Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp Thr Tyr Phe 
            420                 425                 430         


Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg Lys Gly Lys 
        435                 440                 445             


Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp Ile Asp Arg 
    450                 455                 460                 


Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His Ala Pro Glu 
465                 470                 475                 480 


Val Ile Thr Ser Ser Pro Leu Lys 
                485             


<210>  3745
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F11__Homo_sapiens__NP_000119

<400>  3745

Met Ile Phe Leu Tyr Gln Val Val His Phe Ile Leu Phe Thr Ser Val 
1               5                   10                  15      


Ser Gly Glu Cys Val Thr Gln Leu Leu Lys Asp Thr Cys Phe Glu Gly 
            20                  25                  30          


Gly Asp Ile Thr Thr Val Phe Thr Pro Ser Ala Lys Tyr Cys Gln Val 
        35                  40                  45              


Val Cys Thr Tyr His Pro Arg Cys Leu Leu Phe Thr Phe Thr Ala Glu 
    50                  55                  60                  


Ser Pro Ser Glu Asp Pro Thr Arg Trp Phe Thr Cys Val Leu Lys Asp 
65                  70                  75                  80  


Ser Val Thr Glu Thr Leu Pro Arg Val Asn Arg Thr Ala Ala Ile Ser 
                85                  90                  95      


Gly Tyr Ser Phe Lys Gln Cys Ser His Gln Ile Ser Ala Cys Asn Lys 
            100                 105                 110         


Asp Ile Tyr Val Asp Leu Asp Met Lys Gly Ile Asn Tyr Asn Ser Ser 
        115                 120                 125             


Val Ala Lys Ser Ala Gln Glu Cys Gln Glu Arg Cys Thr Asp Asp Val 
    130                 135                 140                 


His Cys His Phe Phe Thr Tyr Ala Thr Arg Gln Phe Pro Ser Leu Glu 
145                 150                 155                 160 


His Arg Asn Ile Cys Leu Leu Lys His Thr Gln Thr Gly Thr Pro Thr 
                165                 170                 175     


Arg Ile Thr Lys Leu Asp Lys Val Val Ser Gly Phe Ser Leu Lys Ser 
            180                 185                 190         


Cys Ala Leu Ser Asn Leu Ala Cys Ile Arg Asp Ile Phe Pro Asn Thr 
        195                 200                 205             


Val Phe Ala Asp Ser Asn Ile Asp Ser Val Met Ala Pro Asp Ala Phe 
    210                 215                 220                 


Val Cys Gly Arg Ile Cys Thr His His Pro Gly Cys Leu Phe Phe Thr 
225                 230                 235                 240 


Phe Phe Ser Gln Glu Trp Pro Lys Glu Ser Gln Arg Asn Leu Cys Leu 
                245                 250                 255     


Leu Lys Thr Ser Glu Ser Gly Leu Pro Ser Thr Arg Ile Lys Lys Ser 
            260                 265                 270         


Lys Ala Leu Ser Gly Phe Ser Leu Gln Ser Cys Arg His Ser Ile Pro 
        275                 280                 285             


Val Phe Cys His Ser Ser Phe Tyr His Asp Thr Asp Phe Leu Gly Glu 
    290                 295                 300                 


Glu Leu Asp Ile Val Ala Ala Lys Ser His Glu Ala Cys Gln Lys Leu 
305                 310                 315                 320 


Cys Thr Asn Ala Val Arg Cys Gln Phe Phe Thr Tyr Thr Pro Ala Gln 
                325                 330                 335     


Ala Ser Cys Asn Glu Gly Lys Gly Lys Cys Tyr Leu Lys Leu Ser Ser 
            340                 345                 350         


Asn Gly Ser Pro Thr Lys Ile Leu His Gly Arg Gly Gly Ile Ser Gly 
        355                 360                 365             


Tyr Thr Leu Arg Leu Cys Lys Met Asp Asn Glu Cys Thr Thr Lys Ile 
    370                 375                 380                 


Lys Pro Arg Ile Val Gly Gly Thr Ala Ser Val Arg Gly Glu Trp Pro 
385                 390                 395                 400 


Trp Gln Val Thr Leu His Thr Thr Ser Pro Thr Gln Arg His Leu Cys 
                405                 410                 415     


Gly Gly Ser Ile Ile Gly Asn Gln Trp Ile Leu Thr Ala Ala His Cys 
            420                 425                 430         


Phe Tyr Gly Val Glu Ser Pro Lys Ile Leu Arg Val Tyr Ser Gly Ile 
        435                 440                 445             


Leu Asn Gln Ser Glu Ile Lys Glu Asp Thr Ser Phe Phe Gly Val Gln 
    450                 455                 460                 


Glu Ile Ile Ile His Asp Gln Tyr Lys Met Ala Glu Ser Gly Tyr Asp 
465                 470                 475                 480 


Ile Ala Leu Leu Lys Leu Glu Thr Thr Val Asn Tyr Thr Asp Ser Gln 
                485                 490                 495     


Arg Pro Ile Cys Leu Pro Ser Lys Gly Asp Arg Asn Val Ile Tyr Thr 
            500                 505                 510         


Asp Cys Trp Val Thr Gly Trp Gly Tyr Arg Lys Leu Arg Asp Lys Ile 
        515                 520                 525             


Gln Asn Thr Leu Gln Lys Ala Lys Ile Pro Leu Val Thr Asn Glu Glu 
    530                 535                 540                 


Cys Gln Lys Arg Tyr Arg Gly His Lys Ile Thr His Lys Met Ile Cys 
545                 550                 555                 560 


Ala Gly Tyr Arg Glu Gly Gly Lys Asp Ala Cys Lys Gly Asp Ser Gly 
                565                 570                 575     


Gly Pro Leu Ser Cys Lys His Asn Glu Val Trp His Leu Val Gly Ile 
            580                 585                 590         


Thr Ser Trp Gly Glu Gly Cys Ala Gln Arg Glu Arg Pro Gly Val Tyr 
        595                 600                 605             


Thr Asn Val Val Glu Tyr Val Asp Trp Ile Leu Glu Lys Thr Gln Ala 
    610                 615                 620                 


Val 
625 


<210>  3746
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F11R__Homo_sapiens__NP_058642

<400>  3746

Met Gly Thr Lys Ala Gln Val Glu Arg Lys Leu Leu Cys Leu Phe Ile 
1               5                   10                  15      


Leu Ala Ile Leu Leu Cys Ser Leu Ala Leu Gly Ser Val Thr Val His 
            20                  25                  30          


Ser Ser Glu Pro Glu Val Arg Ile Pro Glu Asn Asn Pro Val Lys Leu 
        35                  40                  45              


Ser Cys Ala Tyr Ser Gly Phe Ser Ser Pro Arg Val Glu Trp Lys Phe 
    50                  55                  60                  


Asp Gln Gly Asp Thr Thr Arg Leu Val Cys Tyr Asn Asn Lys Ile Thr 
65                  70                  75                  80  


Ala Ser Tyr Glu Asp Arg Val Thr Phe Leu Pro Thr Gly Ile Thr Phe 
                85                  90                  95      


Lys Ser Val Thr Arg Glu Asp Thr Gly Thr Tyr Thr Cys Met Val Ser 
            100                 105                 110         


Glu Glu Gly Gly Asn Ser Tyr Gly Glu Val Lys Val Lys Leu Ile Val 
        115                 120                 125             


Leu Val Pro Pro Ser Lys Pro Thr Val Asn Ile Pro Ser Ser Ala Thr 
    130                 135                 140                 


Ile Gly Asn Arg Ala Val Leu Thr Cys Ser Glu Gln Asp Gly Ser Pro 
145                 150                 155                 160 


Pro Ser Glu Tyr Thr Trp Phe Lys Asp Gly Ile Val Met Pro Thr Asn 
                165                 170                 175     


Pro Lys Ser Thr Arg Ala Phe Ser Asn Ser Ser Tyr Val Leu Asn Pro 
            180                 185                 190         


Thr Thr Gly Glu Leu Val Phe Asp Pro Leu Ser Ala Ser Asp Thr Gly 
        195                 200                 205             


Glu Tyr Ser Cys Glu Ala Arg Asn Gly Tyr Gly Thr Pro Met Thr Ser 
    210                 215                 220                 


Asn Ala Val Arg Met Glu Ala Val Glu Arg Asn Val Gly Val Ile Val 
225                 230                 235                 240 


Ala Ala Val Leu Val Thr Leu Ile Leu Leu Gly Ile Leu Val Phe Gly 
                245                 250                 255     


Ile Trp Phe Ala Tyr Ser Arg Gly His Phe Asp Arg Thr Lys Lys Gly 
            260                 265                 270         


Thr Ser Ser Lys Lys Val Ile Tyr Ser Gln Pro Ser Ala Arg Ser Glu 
        275                 280                 285             


Gly Glu Phe Lys Gln Thr Ser Ser Phe Leu Val 
    290                 295                 


<210>  3747
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F12__Homo_sapiens__NP_000496

<400>  3747

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  3748
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F13A1__Homo_sapiens__NP_000120

<400>  3748

Met Ser Glu Thr Ser Arg Thr Ala Phe Gly Gly Arg Arg Ala Val Pro 
1               5                   10                  15      


Pro Asn Asn Ser Asn Ala Ala Glu Asp Asp Leu Pro Thr Val Glu Leu 
            20                  25                  30          


Gln Gly Val Val Pro Arg Gly Val Asn Leu Gln Glu Phe Leu Asn Val 
        35                  40                  45              


Thr Ser Val His Leu Phe Lys Glu Arg Trp Asp Thr Asn Lys Val Asp 
    50                  55                  60                  


His His Thr Asp Lys Tyr Glu Asn Asn Lys Leu Ile Val Arg Arg Gly 
65                  70                  75                  80  


Gln Ser Phe Tyr Val Gln Ile Asp Phe Ser Arg Pro Tyr Asp Pro Arg 
                85                  90                  95      


Arg Asp Leu Phe Arg Val Glu Tyr Val Ile Gly Arg Tyr Pro Gln Glu 
            100                 105                 110         


Asn Lys Gly Thr Tyr Ile Pro Val Pro Ile Val Ser Glu Leu Gln Ser 
        115                 120                 125             


Gly Lys Trp Gly Ala Lys Ile Val Met Arg Glu Asp Arg Ser Val Arg 
    130                 135                 140                 


Leu Ser Ile Gln Ser Ser Pro Lys Cys Ile Val Gly Lys Phe Arg Met 
145                 150                 155                 160 


Tyr Val Ala Val Trp Thr Pro Tyr Gly Val Leu Arg Thr Ser Arg Asn 
                165                 170                 175     


Pro Glu Thr Asp Thr Tyr Ile Leu Phe Asn Pro Trp Cys Glu Asp Asp 
            180                 185                 190         


Ala Val Tyr Leu Asp Asn Glu Lys Glu Arg Glu Glu Tyr Val Leu Asn 
        195                 200                 205             


Asp Ile Gly Val Ile Phe Tyr Gly Glu Val Asn Asp Ile Lys Thr Arg 
    210                 215                 220                 


Ser Trp Ser Tyr Gly Gln Phe Glu Asp Gly Ile Leu Asp Thr Cys Leu 
225                 230                 235                 240 


Tyr Val Met Asp Arg Ala Gln Met Asp Leu Ser Gly Arg Gly Asn Pro 
                245                 250                 255     


Ile Lys Val Ser Arg Val Gly Ser Ala Met Val Asn Ala Lys Asp Asp 
            260                 265                 270         


Glu Gly Val Leu Val Gly Ser Trp Asp Asn Ile Tyr Ala Tyr Gly Val 
        275                 280                 285             


Pro Pro Ser Ala Trp Thr Gly Ser Val Asp Ile Leu Leu Glu Tyr Arg 
    290                 295                 300                 


Ser Ser Glu Asn Pro Val Arg Tyr Gly Gln Cys Trp Val Phe Ala Gly 
305                 310                 315                 320 


Val Phe Asn Thr Phe Leu Arg Cys Leu Gly Ile Pro Ala Arg Ile Val 
                325                 330                 335     


Thr Asn Tyr Phe Ser Ala His Asp Asn Asp Ala Asn Leu Gln Met Asp 
            340                 345                 350         


Ile Phe Leu Glu Glu Asp Gly Asn Val Asn Ser Lys Leu Thr Lys Asp 
        355                 360                 365             


Ser Val Trp Asn Tyr His Cys Trp Asn Glu Ala Trp Met Thr Arg Pro 
    370                 375                 380                 


Asp Leu Pro Val Gly Phe Gly Gly Trp Gln Ala Val Asp Ser Thr Pro 
385                 390                 395                 400 


Gln Glu Asn Ser Asp Gly Met Tyr Arg Cys Gly Pro Ala Ser Val Gln 
                405                 410                 415     


Ala Ile Lys His Gly His Val Cys Phe Gln Phe Asp Ala Pro Phe Val 
            420                 425                 430         


Phe Ala Glu Val Asn Ser Asp Leu Ile Tyr Ile Thr Ala Lys Lys Asp 
        435                 440                 445             


Gly Thr His Val Val Glu Asn Val Asp Ala Thr His Ile Gly Lys Leu 
    450                 455                 460                 


Ile Val Thr Lys Gln Ile Gly Gly Asp Gly Met Met Asp Ile Thr Asp 
465                 470                 475                 480 


Thr Tyr Lys Phe Gln Glu Gly Gln Glu Glu Glu Arg Leu Ala Leu Glu 
                485                 490                 495     


Thr Ala Leu Met Tyr Gly Ala Lys Lys Pro Leu Asn Thr Glu Gly Val 
            500                 505                 510         


Met Lys Ser Arg Ser Asn Val Asp Met Asp Phe Glu Val Glu Asn Ala 
        515                 520                 525             


Val Leu Gly Lys Asp Phe Lys Leu Ser Ile Thr Phe Arg Asn Asn Ser 
    530                 535                 540                 


His Asn Arg Tyr Thr Ile Thr Ala Tyr Leu Ser Ala Asn Ile Thr Phe 
545                 550                 555                 560 


Tyr Thr Gly Val Pro Lys Ala Glu Phe Lys Lys Glu Thr Phe Asp Val 
                565                 570                 575     


Thr Leu Glu Pro Leu Ser Phe Lys Lys Glu Ala Val Leu Ile Gln Ala 
            580                 585                 590         


Gly Glu Tyr Met Gly Gln Leu Leu Glu Gln Ala Ser Leu His Phe Phe 
        595                 600                 605             


Val Thr Ala Arg Ile Asn Glu Thr Arg Asp Val Leu Ala Lys Gln Lys 
    610                 615                 620                 


Ser Thr Val Leu Thr Ile Pro Glu Ile Ile Ile Lys Val Arg Gly Thr 
625                 630                 635                 640 


Gln Val Val Gly Ser Asp Met Thr Val Thr Val Glu Phe Thr Asn Pro 
                645                 650                 655     


Leu Lys Glu Thr Leu Arg Asn Val Trp Val His Leu Asp Gly Pro Gly 
            660                 665                 670         


Val Thr Arg Pro Met Lys Lys Met Phe Arg Glu Ile Arg Pro Asn Ser 
        675                 680                 685             


Thr Val Gln Trp Glu Glu Val Cys Arg Pro Trp Val Ser Gly His Arg 
    690                 695                 700                 


Lys Leu Ile Ala Ser Met Ser Ser Asp Ser Leu Arg His Val Tyr Gly 
705                 710                 715                 720 


Glu Leu Asp Val Gln Ile Gln Arg Arg Pro Ser Met 
                725                 730         


<210>  3749
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F13B__Homo_sapiens__NP_001985

<400>  3749

Met Arg Leu Lys Asn Leu Thr Phe Ile Ile Ile Leu Ile Ile Ser Gly 
1               5                   10                  15      


Glu Leu Tyr Ala Glu Glu Lys Pro Cys Gly Phe Pro His Val Glu Asn 
            20                  25                  30          


Gly Arg Ile Ala Gln Tyr Tyr Tyr Thr Phe Lys Ser Phe Tyr Phe Pro 
        35                  40                  45              


Met Ser Ile Asp Lys Lys Leu Ser Phe Phe Cys Leu Ala Gly Tyr Thr 
    50                  55                  60                  


Thr Glu Ser Gly Arg Gln Glu Glu Gln Thr Thr Cys Thr Thr Glu Gly 
65                  70                  75                  80  


Trp Ser Pro Glu Pro Arg Cys Phe Lys Lys Cys Thr Lys Pro Asp Leu 
                85                  90                  95      


Ser Asn Gly Tyr Ile Ser Asp Val Lys Leu Leu Tyr Lys Ile Gln Glu 
            100                 105                 110         


Asn Met Arg Tyr Gly Cys Ala Ser Gly Tyr Lys Thr Thr Gly Gly Lys 
        115                 120                 125             


Asp Glu Glu Val Val Gln Cys Leu Ser Asp Gly Trp Ser Ser Gln Pro 
    130                 135                 140                 


Thr Cys Arg Lys Glu His Glu Thr Cys Leu Ala Pro Glu Leu Tyr Asn 
145                 150                 155                 160 


Gly Asn Tyr Ser Thr Thr Gln Lys Thr Phe Lys Val Lys Asp Lys Val 
                165                 170                 175     


Gln Tyr Glu Cys Ala Thr Gly Tyr Tyr Thr Ala Gly Gly Lys Lys Thr 
            180                 185                 190         


Glu Glu Val Glu Cys Leu Thr Tyr Gly Trp Ser Leu Thr Pro Lys Cys 
        195                 200                 205             


Thr Lys Leu Lys Cys Ser Ser Leu Arg Leu Ile Glu Asn Gly Tyr Phe 
    210                 215                 220                 


His Pro Val Lys Gln Thr Tyr Glu Glu Gly Asp Val Val Gln Phe Phe 
225                 230                 235                 240 


Cys His Glu Asn Tyr Tyr Leu Ser Gly Ser Asp Leu Ile Gln Cys Tyr 
                245                 250                 255     


Asn Phe Gly Trp Tyr Pro Glu Ser Pro Val Cys Glu Gly Arg Arg Asn 
            260                 265                 270         


Arg Cys Pro Pro Pro Pro Leu Pro Ile Asn Ser Lys Ile Gln Thr His 
        275                 280                 285             


Ser Thr Thr Tyr Arg His Gly Glu Ile Val His Ile Glu Cys Glu Leu 
    290                 295                 300                 


Asn Phe Glu Ile His Gly Ser Ala Glu Ile Arg Cys Glu Asp Gly Lys 
305                 310                 315                 320 


Trp Thr Glu Pro Pro Lys Cys Ile Glu Gly Gln Glu Lys Val Ala Cys 
                325                 330                 335     


Glu Glu Pro Pro Phe Ile Glu Asn Gly Ala Ala Asn Leu His Ser Lys 
            340                 345                 350         


Ile Tyr Tyr Asn Gly Asp Lys Val Thr Tyr Ala Cys Lys Ser Gly Tyr 
        355                 360                 365             


Leu Leu His Gly Ser Asn Glu Ile Thr Cys Asn Arg Gly Lys Trp Thr 
    370                 375                 380                 


Leu Pro Pro Glu Cys Val Glu Asn Asn Glu Asn Cys Lys His Pro Pro 
385                 390                 395                 400 


Val Val Met Asn Gly Ala Val Ala Asp Gly Ile Leu Ala Ser Tyr Ala 
                405                 410                 415     


Thr Gly Ser Ser Val Glu Tyr Arg Cys Asn Glu Tyr Tyr Leu Leu Arg 
            420                 425                 430         


Gly Ser Lys Ile Ser Arg Cys Glu Gln Gly Lys Trp Ser Ser Pro Pro 
        435                 440                 445             


Val Cys Leu Glu Pro Cys Thr Val Asn Val Asp Tyr Met Asn Arg Asn 
    450                 455                 460                 


Asn Ile Glu Met Lys Trp Lys Tyr Glu Gly Lys Val Leu His Gly Asp 
465                 470                 475                 480 


Leu Ile Asp Phe Val Cys Lys Gln Gly Tyr Asp Leu Ser Pro Leu Thr 
                485                 490                 495     


Pro Leu Ser Glu Leu Ser Val Gln Cys Asn Arg Gly Glu Val Lys Tyr 
            500                 505                 510         


Pro Leu Cys Thr Arg Lys Glu Ser Lys Gly Met Cys Thr Ser Pro Pro 
        515                 520                 525             


Leu Ile Lys His Gly Val Ile Ile Ser Ser Thr Val Asp Thr Tyr Glu 
    530                 535                 540                 


Asn Gly Ser Ser Val Glu Tyr Arg Cys Phe Asp His His Phe Leu Glu 
545                 550                 555                 560 


Gly Ser Arg Glu Ala Tyr Cys Leu Asp Gly Met Trp Thr Thr Pro Pro 
                565                 570                 575     


Leu Cys Leu Glu Pro Cys Thr Leu Ser Phe Thr Glu Met Glu Lys Asn 
            580                 585                 590         


Asn Leu Leu Leu Lys Trp Asp Phe Asp Asn Arg Pro His Ile Leu His 
        595                 600                 605             


Gly Glu Tyr Ile Glu Phe Ile Cys Arg Gly Asp Thr Tyr Pro Ala Glu 
    610                 615                 620                 


Leu Tyr Ile Thr Gly Ser Ile Leu Arg Met Gln Cys Asp Arg Gly Gln 
625                 630                 635                 640 


Leu Lys Tyr Pro Arg Cys Ile Pro Arg Gln Ser Thr Leu Ser Tyr Gln 
                645                 650                 655     


Glu Pro Leu Arg Thr 
            660     


<210>  3750
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2__Homo_sapiens__NP_000497

<400>  3750

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210>  3751
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2R__Homo_sapiens__NP_001983

<400>  3751

Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
1               5                   10                  15      


Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
            20                  25                  30          


Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
        35                  40                  45              


Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
    50                  55                  60                  


Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
65                  70                  75                  80  


Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                85                  90                  95      


Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
            100                 105                 110         


Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
        115                 120                 125             


Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
    130                 135                 140                 


Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
145                 150                 155                 160 


Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                165                 170                 175     


Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
            180                 185                 190         


Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
        195                 200                 205             


Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
    210                 215                 220                 


Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
225                 230                 235                 240 


Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                245                 250                 255     


Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
            260                 265                 270         


Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
        275                 280                 285             


Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
    290                 295                 300                 


Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
305                 310                 315                 320 


Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His 
                325                 330                 335     


Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
            340                 345                 350         


Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
        355                 360                 365             


Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
    370                 375                 380                 


Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
385                 390                 395                 400 


Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                405                 410                 415     


Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
            420                 425 


<210>  3752
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2RL1__Homo_sapiens__NP_005233

<400>  3752

Met Arg Ser Pro Ser Ala Ala Trp Leu Leu Gly Ala Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ala Ser Leu Ser Cys Ser Gly Thr Ile Gln Gly Thr Asn Arg Ser 
            20                  25                  30          


Ser Lys Gly Arg Ser Leu Ile Gly Lys Val Asp Gly Thr Ser His Val 
        35                  40                  45              


Thr Gly Lys Gly Val Thr Val Glu Thr Val Phe Ser Val Asp Glu Phe 
    50                  55                  60                  


Ser Ala Ser Val Leu Thr Gly Lys Leu Thr Thr Val Phe Leu Pro Ile 
65                  70                  75                  80  


Val Tyr Thr Ile Val Phe Val Val Gly Leu Pro Ser Asn Gly Met Ala 
                85                  90                  95      


Leu Trp Val Phe Leu Phe Arg Thr Lys Lys Lys His Pro Ala Val Ile 
            100                 105                 110         


Tyr Met Ala Asn Leu Ala Leu Ala Asp Leu Leu Ser Val Ile Trp Phe 
        115                 120                 125             


Pro Leu Lys Ile Ala Tyr His Ile His Gly Asn Asn Trp Ile Tyr Gly 
    130                 135                 140                 


Glu Ala Leu Cys Asn Val Leu Ile Gly Phe Phe Tyr Gly Asn Met Tyr 
145                 150                 155                 160 


Cys Ser Ile Leu Phe Met Thr Cys Leu Ser Val Gln Arg Tyr Trp Val 
                165                 170                 175     


Ile Val Asn Pro Met Gly His Ser Arg Lys Lys Ala Asn Ile Ala Ile 
            180                 185                 190         


Gly Ile Ser Leu Ala Ile Trp Leu Leu Ile Leu Leu Val Thr Ile Pro 
        195                 200                 205             


Leu Tyr Val Val Lys Gln Thr Ile Phe Ile Pro Ala Leu Asn Ile Thr 
    210                 215                 220                 


Thr Cys His Asp Val Leu Pro Glu Gln Leu Leu Val Gly Asp Met Phe 
225                 230                 235                 240 


Asn Tyr Phe Leu Ser Leu Ala Ile Gly Val Phe Leu Phe Pro Ala Phe 
                245                 250                 255     


Leu Thr Ala Ser Ala Tyr Val Leu Met Ile Arg Met Leu Arg Ser Ser 
            260                 265                 270         


Ala Met Asp Glu Asn Ser Glu Lys Lys Arg Lys Arg Ala Ile Lys Leu 
        275                 280                 285             


Ile Val Thr Val Leu Ala Met Tyr Leu Ile Cys Phe Thr Pro Ser Asn 
    290                 295                 300                 


Leu Leu Leu Val Val His Tyr Phe Leu Ile Lys Ser Gln Gly Gln Ser 
305                 310                 315                 320 


His Val Tyr Ala Leu Tyr Ile Val Ala Leu Cys Leu Ser Thr Leu Asn 
                325                 330                 335     


Ser Cys Ile Asp Pro Phe Val Tyr Tyr Phe Val Ser His Asp Phe Arg 
            340                 345                 350         


Asp His Ala Lys Asn Ala Leu Leu Cys Arg Ser Val Arg Thr Val Lys 
        355                 360                 365             


Gln Met Gln Val Ser Leu Thr Ser Lys Lys His Ser Arg Lys Ser Ser 
    370                 375                 380                 


Ser Tyr Ser Ser Ser Ser Thr Thr Val Lys Thr Ser Tyr 
385                 390                 395         


<210>  3753
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2RL2__Homo_sapiens__NP_001243495

<400>  3753

Met Glu Asn Asp Thr Asn Asn Leu Ala Lys Pro Thr Leu Pro Ile Lys 
1               5                   10                  15      


Thr Phe Arg Gly Ala Pro Pro Asn Ser Phe Glu Glu Phe Pro Phe Ser 
            20                  25                  30          


Ala Leu Glu Gly Trp Thr Gly Ala Thr Ile Thr Val Lys Ile Lys Cys 
        35                  40                  45              


Pro Glu Glu Ser Ala Ser His Leu His Val Lys Asn Ala Thr Met Gly 
    50                  55                  60                  


Tyr Leu Thr Ser Ser Leu Ser Thr Lys Leu Ile Pro Ala Ile Tyr Leu 
65                  70                  75                  80  


Leu Val Phe Val Val Gly Val Pro Ala Asn Ala Val Thr Leu Trp Met 
                85                  90                  95      


Leu Phe Phe Arg Thr Arg Ser Ile Cys Thr Thr Val Phe Tyr Thr Asn 
            100                 105                 110         


Leu Ala Ile Ala Asp Phe Leu Phe Cys Val Thr Leu Pro Phe Lys Ile 
        115                 120                 125             


Ala Tyr His Leu Asn Gly Asn Asn Trp Val Phe Gly Glu Val Leu Cys 
    130                 135                 140                 


Arg Ala Thr Thr Val Ile Phe Tyr Gly Asn Met Tyr Cys Ser Ile Leu 
145                 150                 155                 160 


Leu Leu Ala Cys Ile Ser Ile Asn Arg Tyr Leu Ala Ile Val His Pro 
                165                 170                 175     


Phe Thr Tyr Arg Gly Leu Pro Lys His Thr Tyr Ala Leu Val Thr Cys 
            180                 185                 190         


Gly Leu Val Trp Ala Thr Val Phe Leu Tyr Met Leu Pro Phe Phe Ile 
        195                 200                 205             


Leu Lys Gln Glu Tyr Tyr Leu Val Gln Pro Asp Ile Thr Thr Cys His 
    210                 215                 220                 


Asp Val His Asn Thr Cys Glu Ser Ser Ser Pro Phe Gln Leu Tyr Tyr 
225                 230                 235                 240 


Phe Ile Ser Leu Ala Phe Phe Gly Phe Leu Ile Pro Phe Val Leu Ile 
                245                 250                 255     


Ile Tyr Cys Tyr Ala Ala Ile Ile Arg Thr Leu Asn Ala Tyr Asp His 
            260                 265                 270         


Arg Trp Leu Trp Tyr Val Lys Ala Ser Leu Leu Ile Leu Val Ile Phe 
        275                 280                 285             


Thr Ile Cys Phe Ala Pro Ser Asn Ile Ile Leu Ile Ile His His Ala 
    290                 295                 300                 


Asn Tyr Tyr Tyr Asn Asn Thr Asp Gly Leu Tyr Phe Ile Tyr Leu Ile 
305                 310                 315                 320 


Ala Leu Cys Leu Gly Ser Leu Asn Ser Cys Leu Asp Pro Phe Leu Tyr 
                325                 330                 335     


Phe Leu Met Ser Lys Thr Arg Asn His Ser Thr Ala Tyr Leu Thr Lys 
            340                 345                 350         


<210>  3754
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2RL3__Homo_sapiens__NP_003941

<400>  3754

Met Trp Gly Arg Leu Leu Leu Trp Pro Leu Val Leu Gly Phe Ser Leu 
1               5                   10                  15      


Ser Gly Gly Thr Gln Thr Pro Ser Val Tyr Asp Glu Ser Gly Ser Thr 
            20                  25                  30          


Gly Gly Gly Asp Asp Ser Thr Pro Ser Ile Leu Pro Ala Pro Arg Gly 
        35                  40                  45              


Tyr Pro Gly Gln Val Cys Ala Asn Asp Ser Asp Thr Leu Glu Leu Pro 
    50                  55                  60                  


Asp Ser Ser Arg Ala Leu Leu Leu Gly Trp Val Pro Thr Arg Leu Val 
65                  70                  75                  80  


Pro Ala Leu Tyr Gly Leu Val Leu Val Val Gly Leu Pro Ala Asn Gly 
                85                  90                  95      


Leu Ala Leu Trp Val Leu Ala Thr Gln Ala Pro Arg Leu Pro Ser Thr 
            100                 105                 110         


Met Leu Leu Met Asn Leu Ala Ala Ala Asp Leu Leu Leu Ala Leu Ala 
        115                 120                 125             


Leu Pro Pro Arg Ile Ala Tyr His Leu Arg Gly Gln Arg Trp Pro Phe 
    130                 135                 140                 


Gly Glu Ala Ala Cys Arg Leu Ala Thr Ala Ala Leu Tyr Gly His Met 
145                 150                 155                 160 


Tyr Gly Ser Val Leu Leu Leu Ala Ala Val Ser Leu Asp Arg Tyr Leu 
                165                 170                 175     


Ala Leu Val His Pro Leu Arg Ala Arg Ala Leu Arg Gly Arg Arg Leu 
            180                 185                 190         


Ala Leu Gly Leu Cys Met Ala Ala Trp Leu Met Ala Ala Ala Leu Ala 
        195                 200                 205             


Leu Pro Leu Thr Leu Gln Arg Gln Thr Phe Arg Leu Ala Arg Ser Asp 
    210                 215                 220                 


Arg Val Leu Cys His Asp Ala Leu Pro Leu Asp Ala Gln Ala Ser His 
225                 230                 235                 240 


Trp Gln Pro Ala Phe Thr Cys Leu Ala Leu Leu Gly Cys Phe Leu Pro 
                245                 250                 255     


Leu Leu Ala Met Leu Leu Cys Tyr Gly Ala Thr Leu His Thr Leu Ala 
            260                 265                 270         


Ala Ser Gly Arg Arg Tyr Gly His Ala Leu Arg Leu Thr Ala Val Val 
        275                 280                 285             


Leu Ala Ser Ala Val Ala Phe Phe Val Pro Ser Asn Leu Leu Leu Leu 
    290                 295                 300                 


Leu His Tyr Ser Asp Pro Ser Pro Ser Ala Trp Gly Asn Leu Tyr Gly 
305                 310                 315                 320 


Ala Tyr Val Pro Ser Leu Ala Leu Ser Thr Leu Asn Ser Cys Val Asp 
                325                 330                 335     


Pro Phe Ile Tyr Tyr Tyr Val Ser Ala Glu Phe Arg Asp Lys Val Arg 
            340                 345                 350         


Ala Gly Leu Phe Gln Arg Ser Pro Gly Asp Thr Val Ala Ser Lys Ala 
        355                 360                 365             


Ser Ala Glu Gly Gly Ser Arg Gly Met Gly Thr His Ser Ser Leu Leu 
    370                 375                 380                 


Gln 
385 


<210>  3755
<211>  2224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5__Homo_sapiens__NP_000121

<400>  3755

Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr Ile Asn Gly Tyr 
            580                 585                 590         


Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe Asp Asp Thr Val 
        595                 600                 605             


Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu Ile Leu Thr Ile 
    610                 615                 620                 


His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg His Glu Asp Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr Val Thr Met Asp 
                645                 650                 655     


Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser 
            660                 665                 670         


Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys Ile Pro Asp Asp 
        675                 680                 685             


Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu Ser Thr Val Met 
    690                 695                 700                 


Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu Asp Glu Glu Ser 
705                 710                 715                 720 


Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala Ala Leu Gly Ile 
                725                 730                 735     


Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu Glu Glu Phe Asn 
            740                 745                 750         


Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe Val Ser Ser Asn 
        755                 760                 765             


Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro Ser Asn Ile Ser 
    770                 775                 780                 


Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys Ala Pro Ser His 
785                 790                 795                 800 


Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His Leu Ile Gly Lys 
                805                 810                 815     


Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr Ser 
            820                 825                 830         


Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile Arg 
        835                 840                 845             


Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln Glu His Ala Lys 
    850                 855                 860                 


His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala Lys His Arg Phe 
865                 870                 875                 880 


Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg His Leu Ser Gln 
                885                 890                 895     


Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu Asp Leu Pro Ser 
            900                 905                 910         


Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp Lys Asp Pro Pro 
        915                 920                 925             


Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser Lys Ile Leu Val 
    930                 935                 940                 


Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr Glu Ile Ile Gln 
945                 950                 955                 960 


Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu Ile Ser Pro Gln 
                965                 970                 975     


Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu Ala Asn Lys Pro 
            980                 985                 990         


Gly Lys Gln Ser Gly His Pro Lys  Phe Pro Arg Val Arg  His Lys Ser 
        995                 1000                 1005             


Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser Arg Leu  Lys Lys Ser 
    1010                 1015                 1020             


Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys Lys Glu  Lys His Thr 
    1025                 1030                 1035             


His His  Ala Pro Leu Ser Pro  Arg Thr Phe His Pro  Leu Arg Ser 
    1040                 1045                 1050             


Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg Leu Lys  His Ser Leu 
    1055                 1060                 1065             


Val Leu  His Lys Ser Asn Glu  Thr Ser Leu Pro Thr  Asp Leu Asn 
    1070                 1075                 1080             


Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp Ile Ala  Ser Leu Pro 
    1085                 1090                 1095             


Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr Gly Gln  Ala Ser Cys 
    1100                 1105                 1110             


Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro Glu Glu  His Tyr Gln 
    1115                 1120                 1125             


Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met His Ser  Thr Ser Asp 
    1130                 1135                 1140             


Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu Ser Glu  Met Leu Glu 
    1145                 1150                 1155             


Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr Asp Ile  Ser Gln Met 
    1160                 1165                 1170             


Ser Pro  Ser Ser Glu His Glu  Val Trp Gln Thr Val  Ile Ser Pro 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1190                 1195                 1200             


Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu Ser Pro  Glu Leu Ile 
    1205                 1210                 1215             


Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1220                 1225                 1230             


Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp Leu Ser  His Thr Thr 
    1235                 1240                 1245             


Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu Ser Pro  Glu Leu Ser 
    1250                 1255                 1260             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Leu Ser Pro 
    1265                 1270                 1275             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1280                 1285                 1290             


Leu Ser  Pro Glu Leu Ser His  Met Thr Leu Ser Pro  Glu Leu Ser 
    1295                 1300                 1305             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1310                 1315                 1320             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1325                 1330                 1335             


Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu Ser Pro  Ala Leu Gly 
    1340                 1345                 1350             


Gln Met  Pro Leu Ser Pro Asp  Pro Ser His Thr Thr  Leu Ser Leu 
    1355                 1360                 1365             


Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1370                 1375                 1380             


Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu Phe Ala  Asp Leu Ser 
    1385                 1390                 1395             


Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln Met Thr  Leu Ser Pro 
    1400                 1405                 1410             


Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn Phe Gly  Gln Met Ser 
    1415                 1420                 1425             


Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu Ser Pro  Asp Ile Ser 
    1430                 1435                 1440             


Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln Ile Ser  Pro Pro Pro 
    1445                 1450                 1455             


Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu Ser Ser  Gln Ser Leu 
    1460                 1465                 1470             


Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro Tyr Pro  Asp Leu Gly 
    1475                 1480                 1485             


Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu Asn Asp  Thr Phe Leu 
    1490                 1495                 1500             


Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val Gly Leu  Ser Lys Asp 
    1505                 1510                 1515             


Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys Glu Glu  Val Gln Ser 
    1520                 1525                 1530             


Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr Val Pro  Tyr Asp Asp 
    1535                 1540                 1545             


Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile Asn Ser  Ser Arg Asp 
    1550                 1555                 1560             


Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg Ser Asn  Asn Gly Asn 
    1565                 1570                 1575             


Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu Ile Ser  Trp Asp Tyr 
    1580                 1585                 1590             


Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile Glu Asp  Ser Asp Asp 
    1595                 1600                 1605             


Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val Val Phe  Arg Lys Tyr 
    1610                 1615                 1620             


Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro Arg Gly  Glu Tyr Glu 
    1625                 1630                 1635             


Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile Arg Ala  Glu Val Asp 
    1640                 1645                 1650             


Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu Ala Ser  Arg Pro Tyr 
    1655                 1660                 1665             


Ser Leu  His Ala His Gly Leu  Ser Tyr Glu Lys Ser  Ser Glu Gly 
    1670                 1675                 1680             


Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp Phe Lys  Glu Asp Asn 
    1685                 1690                 1695             


Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr Val Trp  His Ala Thr 
    1700                 1705                 1710             


Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser Ala Cys  Arg Ala Trp 
    1715                 1720                 1725             


Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys Asp Ile  His Ser Gly 
    1730                 1735                 1740             


Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys Gly Ile  Leu His Lys 
    1745                 1750                 1755             


Asp Ser  Asn Met Pro Met Asp  Met Arg Glu Phe Val  Leu Leu Phe 
    1760                 1765                 1770             


Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr Tyr Glu  Lys Lys Ser 
    1775                 1780                 1785             


Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu Met Lys  Lys Ser His 
    1790                 1795                 1800             


Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr Ser Leu  Pro Gly Leu 
    1805                 1810                 1815             


Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu His Leu  Leu Asn Ile 
    1820                 1825                 1830             


Gly Gly  Ser Gln Asp Ile His  Val Val His Phe His  Gly Gln Thr 
    1835                 1840                 1845             


Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln Leu Gly  Val Trp Pro 
    1850                 1855                 1860             


Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu Met Lys  Ala Ser Lys 
    1865                 1870                 1875             


Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val Gly Glu  Asn Gln Arg 
    1880                 1885                 1890             


Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met Asp Arg  Asp Cys Arg 
    1895                 1900                 1905             


Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile Ser Asp  Ser Gln Ile 
    1910                 1915                 1920             


Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu Pro Arg  Leu Ala Arg 
    1925                 1930                 1935             


Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp Ser Val  Glu Lys Leu 
    1940                 1945                 1950             


Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile Gln Val  Asp Met Gln 
    1955                 1960                 1965             


Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr Gln Gly  Ala Lys His 
    1970                 1975                 1980             


Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe Tyr Val  Ala Tyr Ser 
    1985                 1990                 1995             


Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys Gly Asn  Ser Thr Arg 
    2000                 2005                 2010             


Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp Ala Ser  Thr Ile Lys 
    2015                 2020                 2025             


Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala Arg Tyr  Ile Arg Ile 
    2030                 2035                 2040             


Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr Leu Arg  Leu Glu Leu 
    2045                 2050                 2055             


Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr Pro Leu  Gly Met Glu 
    2060                 2065                 2070             


Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr Ala Ser  Ser Phe Lys 
    2075                 2080                 2085             


Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro Phe Arg  Ala Arg Leu 
    2090                 2095                 2100             


Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln Ala Lys  Ala Asn Asn 
    2105                 2110                 2115             


Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu Lys Ile  Lys Lys Ile 
    2120                 2125                 2130             


Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser Leu Ser  Ser Glu Met 
    2135                 2140                 2145             


Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser Glu Gln  Gly Val Glu 
    2150                 2155                 2160             


Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met Val Asp  Lys Ile Phe 
    2165                 2170                 2175             


Glu Gly  Asn Thr Asn Thr Lys  Gly His Val Lys Asn  Phe Phe Asn 
    2180                 2185                 2190             


Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val Ile Pro  Lys Thr Trp 
    2195                 2200                 2205             


Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu Phe Gly  Cys Asp Ile 
    2210                 2215                 2220             


Tyr 
    


<210>  3756
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F7__Homo_sapiens__NP_000122

<400>  3756

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Gly Gly Val Ala Lys Ala Ser Gly Gly Glu Thr 
            20                  25                  30          


Arg Asp Met Pro Trp Lys Pro Gly Pro His Arg Val Phe Val Thr Gln 
        35                  40                  45              


Glu Glu Ala His Gly Val Leu His Arg Arg Arg Arg Ala Asn Ala Phe 
    50                  55                  60                  


Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu 
65                  70                  75                  80  


Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg 
                85                  90                  95      


Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser 
            100                 105                 110         


Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr 
        115                 120                 125             


Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn Cys Glu Thr His 
    130                 135                 140                 


Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly Gly Cys Glu Gln 
145                 150                 155                 160 


Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys Arg Cys His Glu 
                165                 170                 175     


Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr Pro Thr Val Glu 
            180                 185                 190         


Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys 
        195                 200                 205             


Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys 
    210                 215                 220                 


Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly 
225                 230                 235                 240 


Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp 
                245                 250                 255     


Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp 
            260                 265                 270         


Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val 
        275                 280                 285             


Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala 
    290                 295                 300                 


Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro 
305                 310                 315                 320 


Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val 
                325                 330                 335     


Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala 
            340                 345                 350         


Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln 
        355                 360                 365             


Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr 
    370                 375                 380                 


Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys 
385                 390                 395                 400 


Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp 
                405                 410                 415     


Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly 
            420                 425                 430         


His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln 
        435                 440                 445             


Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro 
    450                 455                 460                 


Phe Pro 
465     


<210>  3757
<211>  2351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8__Homo_sapiens__NP_000123

<400>  3757

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  3758
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F9__Homo_sapiens__NP_000124

<400>  3758

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  3759
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FA2H__Homo_sapiens__NP_077282

<400>  3759

Met Ala Pro Ala Pro Pro Pro Ala Ala Ser Phe Ser Pro Ser Glu Val 
1               5                   10                  15      


Gln Arg Arg Leu Ala Ala Gly Ala Cys Trp Val Arg Arg Gly Ala Arg 
            20                  25                  30          


Leu Tyr Asp Leu Ser Ser Phe Val Arg His His Pro Gly Gly Glu Gln 
        35                  40                  45              


Leu Leu Arg Ala Arg Ala Gly Gln Asp Ile Ser Ala Asp Leu Asp Gly 
    50                  55                  60                  


Pro Pro His Arg His Ser Ala Asn Ala Arg Arg Trp Leu Glu Gln Tyr 
65                  70                  75                  80  


Tyr Val Gly Glu Leu Arg Gly Glu Gln Gln Gly Ser Met Glu Asn Glu 
                85                  90                  95      


Pro Val Ala Leu Glu Glu Thr Gln Lys Thr Asp Pro Ala Met Glu Pro 
            100                 105                 110         


Arg Phe Lys Val Val Asp Trp Asp Lys Asp Leu Val Asp Trp Arg Lys 
        115                 120                 125             


Pro Leu Leu Trp Gln Val Gly His Leu Gly Glu Lys Tyr Asp Glu Trp 
    130                 135                 140                 


Val His Gln Pro Val Thr Arg Pro Ile Arg Leu Phe His Ser Asp Leu 
145                 150                 155                 160 


Ile Glu Gly Leu Ser Lys Thr Val Trp Tyr Ser Val Pro Ile Ile Trp 
                165                 170                 175     


Val Pro Leu Val Leu Tyr Leu Ser Trp Ser Tyr Tyr Arg Thr Phe Ala 
            180                 185                 190         


Gln Gly Asn Val Arg Leu Phe Thr Ser Phe Thr Thr Glu Tyr Thr Val 
        195                 200                 205             


Ala Val Pro Lys Ser Met Phe Pro Gly Leu Phe Met Leu Gly Thr Phe 
    210                 215                 220                 


Leu Trp Ser Leu Ile Glu Tyr Leu Ile His Arg Phe Leu Phe His Met 
225                 230                 235                 240 


Lys Pro Pro Ser Asp Ser Tyr Tyr Leu Ile Met Leu His Phe Val Met 
                245                 250                 255     


His Gly Gln His His Lys Ala Pro Phe Asp Gly Ser Arg Leu Val Phe 
            260                 265                 270         


Pro Pro Val Pro Ala Ser Leu Val Ile Gly Val Phe Tyr Leu Cys Met 
        275                 280                 285             


Gln Leu Ile Leu Pro Glu Ala Val Gly Gly Thr Val Phe Ala Gly Gly 
    290                 295                 300                 


Leu Leu Gly Tyr Val Leu Tyr Asp Met Thr His Tyr Tyr Leu His Phe 
305                 310                 315                 320 


Gly Ser Pro His Lys Gly Ser Tyr Leu Tyr Ser Leu Lys Ala His His 
                325                 330                 335     


Val Lys His His Phe Ala His Gln Lys Ser Gly Phe Gly Ile Ser Thr 
            340                 345                 350         


Lys Leu Trp Asp Tyr Cys Phe His Thr Leu Thr Pro Glu Lys Pro His 
        355                 360                 365             


Leu Lys Thr Gln 
    370         


<210>  3760
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAAH2__Homo_sapiens__NP_777572

<400>  3760

Met Ala Pro Ser Phe Thr Ala Arg Ile Gln Leu Phe Leu Leu Arg Ala 
1               5                   10                  15      


Leu Gly Phe Leu Ile Gly Leu Val Gly Arg Ala Ala Leu Val Leu Gly 
            20                  25                  30          


Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg Pro Val Thr Glu Pro Leu 
        35                  40                  45              


Leu Leu Leu Ser Gly Met Gln Leu Ala Lys Leu Ile Arg Gln Arg Lys 
    50                  55                  60                  


Val Lys Cys Ile Asp Val Val Gln Ala Tyr Ile Asn Arg Ile Lys Asp 
65                  70                  75                  80  


Val Asn Pro Met Ile Asn Gly Ile Val Lys Tyr Arg Phe Glu Glu Ala 
                85                  90                  95      


Met Lys Glu Ala His Ala Val Asp Gln Lys Leu Ala Glu Lys Gln Glu 
            100                 105                 110         


Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro Phe Leu Gly Val Pro Leu 
        115                 120                 125             


Thr Val Lys Glu Ala Phe Gln Leu Gln Gly Met Pro Asn Ser Ser Gly 
    130                 135                 140                 


Leu Met Asn Arg Arg Asp Ala Ile Ala Lys Thr Asp Ala Thr Val Val 
145                 150                 155                 160 


Ala Leu Leu Lys Gly Ala Gly Ala Ile Pro Leu Gly Ile Thr Asn Cys 
                165                 170                 175     


Ser Glu Leu Cys Met Trp Tyr Glu Ser Ser Asn Lys Ile Tyr Gly Arg 
            180                 185                 190         


Ser Asn Asn Pro Tyr Asp Leu Gln His Ile Val Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Glu Gly Cys Thr Leu Ala Ala Ala Cys Ser Val Ile Gly Val Gly 
    210                 215                 220                 


Ser Asp Ile Gly Gly Ser Ile Arg Met Pro Ala Phe Phe Asn Gly Ile 
225                 230                 235                 240 


Phe Gly His Lys Pro Ser Pro Gly Val Val Pro Asn Lys Gly Gln Phe 
                245                 250                 255     


Pro Leu Ala Val Gly Ala Gln Glu Leu Phe Leu Cys Thr Gly Pro Met 
            260                 265                 270         


Cys Arg Tyr Ala Glu Asp Leu Ala Pro Met Leu Lys Val Met Ala Gly 
        275                 280                 285             


Pro Gly Ile Lys Arg Leu Lys Leu Asp Thr Lys Val His Leu Lys Asp 
    290                 295                 300                 


Leu Lys Phe Tyr Trp Met Glu His Asp Gly Gly Ser Phe Leu Met Ser 
305                 310                 315                 320 


Lys Val Asp Gln Asp Leu Ile Met Thr Gln Lys Lys Val Val Val His 
                325                 330                 335     


Leu Glu Thr Ile Leu Gly Ala Ser Val Gln His Val Lys Leu Lys Lys 
            340                 345                 350         


Met Lys Tyr Ser Phe Gln Leu Trp Ile Ala Met Met Ser Ala Lys Gly 
        355                 360                 365             


His Asp Gly Lys Glu Pro Val Lys Phe Val Asp Leu Leu Gly Asp His 
    370                 375                 380                 


Gly Lys His Val Ser Pro Leu Trp Glu Leu Ile Lys Trp Cys Leu Gly 
385                 390                 395                 400 


Leu Ser Val Tyr Thr Ile Pro Ser Ile Gly Leu Ala Leu Leu Glu Glu 
                405                 410                 415     


Lys Leu Arg Tyr Ser Asn Glu Lys Tyr Gln Lys Phe Lys Ala Val Glu 
            420                 425                 430         


Glu Ser Leu Arg Lys Glu Leu Val Asp Met Leu Gly Asp Asp Gly Val 
        435                 440                 445             


Phe Leu Tyr Pro Ser His Pro Thr Val Ala Pro Lys His His Val Pro 
    450                 455                 460                 


Leu Thr Arg Pro Phe Asn Phe Ala Tyr Thr Gly Val Phe Ser Ala Leu 
465                 470                 475                 480 


Gly Leu Pro Val Thr Gln Cys Pro Leu Gly Leu Asn Ala Lys Gly Leu 
                485                 490                 495     


Pro Leu Gly Ile Gln Val Val Ala Gly Pro Phe Asn Asp His Leu Thr 
            500                 505                 510         


Leu Ala Val Ala Gln Tyr Leu Glu Lys Thr Phe Gly Gly Trp Val Cys 
        515                 520                 525             


Pro Gly Lys Phe 
    530         


<210>  3761
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FABP1__Homo_sapiens__NP_001434

<400>  3761

Met Ser Phe Ser Gly Lys Tyr Gln Leu Gln Ser Gln Glu Asn Phe Glu 
1               5                   10                  15      


Ala Phe Met Lys Ala Ile Gly Leu Pro Glu Glu Leu Ile Gln Lys Gly 
            20                  25                  30          


Lys Asp Ile Lys Gly Val Ser Glu Ile Val Gln Asn Gly Lys His Phe 
        35                  40                  45              


Lys Phe Thr Ile Thr Ala Gly Ser Lys Val Ile Gln Asn Glu Phe Thr 
    50                  55                  60                  


Val Gly Glu Glu Cys Glu Leu Glu Thr Met Thr Gly Glu Lys Val Lys 
65                  70                  75                  80  


Thr Val Val Gln Leu Glu Gly Asp Asn Lys Leu Val Thr Thr Phe Lys 
                85                  90                  95      


Asn Ile Lys Ser Val Thr Glu Leu Asn Gly Asp Ile Ile Thr Asn Thr 
            100                 105                 110         


Met Thr Leu Gly Asp Ile Val Phe Lys Arg Ile Ser Lys Arg Ile 
        115                 120                 125         


<210>  3762
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FABP2__Homo_sapiens__NP_000125

<400>  3762

Met Ala Phe Asp Ser Thr Trp Lys Val Asp Arg Ser Glu Asn Tyr Asp 
1               5                   10                  15      


Lys Phe Met Glu Lys Met Gly Val Asn Ile Val Lys Arg Lys Leu Ala 
            20                  25                  30          


Ala His Asp Asn Leu Lys Leu Thr Ile Thr Gln Glu Gly Asn Lys Phe 
        35                  40                  45              


Thr Val Lys Glu Ser Ser Thr Phe Arg Asn Ile Glu Val Val Phe Glu 
    50                  55                  60                  


Leu Gly Val Thr Phe Asn Tyr Asn Leu Ala Asp Gly Thr Glu Leu Arg 
65                  70                  75                  80  


Gly Thr Trp Ser Leu Glu Gly Asn Lys Leu Ile Gly Lys Phe Lys Arg 
                85                  90                  95      


Thr Asp Asn Gly Asn Glu Leu Asn Thr Val Arg Glu Ile Ile Gly Asp 
            100                 105                 110         


Glu Leu Val Gln Thr Tyr Val Tyr Glu Gly Val Glu Ala Lys Arg Ile 
        115                 120                 125             


Phe Lys Lys Asp 
    130         


<210>  3763
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FABP4__Homo_sapiens__NP_001433

<400>  3763

Met Cys Asp Ala Phe Val Gly Thr Trp Lys Leu Val Ser Ser Glu Asn 
1               5                   10                  15      


Phe Asp Asp Tyr Met Lys Glu Val Gly Val Gly Phe Ala Thr Arg Lys 
            20                  25                  30          


Val Ala Gly Met Ala Lys Pro Asn Met Ile Ile Ser Val Asn Gly Asp 
        35                  40                  45              


Val Ile Thr Ile Lys Ser Glu Ser Thr Phe Lys Asn Thr Glu Ile Ser 
    50                  55                  60                  


Phe Ile Leu Gly Gln Glu Phe Asp Glu Val Thr Ala Asp Asp Arg Lys 
65                  70                  75                  80  


Val Lys Ser Thr Ile Thr Leu Asp Gly Gly Val Leu Val His Val Gln 
                85                  90                  95      


Lys Trp Asp Gly Lys Ser Thr Thr Ile Lys Arg Lys Arg Glu Asp Asp 
            100                 105                 110         


Lys Leu Val Val Glu Cys Val Met Lys Gly Val Thr Ser Thr Arg Val 
        115                 120                 125             


Tyr Glu Arg Ala 
    130         


<210>  3764
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FABP5__Homo_sapiens__NP_001435

<400>  3764

Met Ala Thr Val Gln Gln Leu Glu Gly Arg Trp Arg Leu Val Asp Ser 
1               5                   10                  15      


Lys Gly Phe Asp Glu Tyr Met Lys Glu Leu Gly Val Gly Ile Ala Leu 
            20                  25                  30          


Arg Lys Met Gly Ala Met Ala Lys Pro Asp Cys Ile Ile Thr Cys Asp 
        35                  40                  45              


Gly Lys Asn Leu Thr Ile Lys Thr Glu Ser Thr Leu Lys Thr Thr Gln 
    50                  55                  60                  


Phe Ser Cys Thr Leu Gly Glu Lys Phe Glu Glu Thr Thr Ala Asp Gly 
65                  70                  75                  80  


Arg Lys Thr Gln Thr Val Cys Asn Phe Thr Asp Gly Ala Leu Val Gln 
                85                  90                  95      


His Gln Glu Trp Asp Gly Lys Glu Ser Thr Ile Thr Arg Lys Leu Lys 
            100                 105                 110         


Asp Gly Lys Leu Val Val Glu Cys Val Met Asn Asn Val Thr Cys Thr 
        115                 120                 125             


Arg Ile Tyr Glu Lys Val Glu 
    130                 135 


<210>  3765
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FABP6__Homo_sapiens__NP_001124430

<400>  3765

Met Lys Thr Val Thr Met Met Met Val Val Glu Met Gln Ala Leu Thr 
1               5                   10                  15      


Gln Val Leu Arg Ala Val Leu Ser Ala Cys Thr Trp Val Ser Arg Lys 
            20                  25                  30          


Gly Asp Leu Gln Arg Met Lys Gln Thr His Lys Gly Lys Pro Pro Ser 
        35                  40                  45              


Ser Met Ala Phe Thr Gly Lys Phe Glu Met Glu Ser Glu Lys Asn Tyr 
    50                  55                  60                  


Asp Glu Phe Met Lys Leu Leu Gly Ile Ser Ser Asp Val Ile Glu Lys 
65                  70                  75                  80  


Ala Arg Asn Phe Lys Ile Val Thr Glu Val Gln Gln Asp Gly Gln Asp 
                85                  90                  95      


Phe Thr Trp Ser Gln His Tyr Ser Gly Gly His Thr Met Thr Asn Lys 
            100                 105                 110         


Phe Thr Val Gly Lys Glu Ser Asn Ile Gln Thr Met Gly Gly Lys Thr 
        115                 120                 125             


Phe Lys Ala Thr Val Gln Met Glu Gly Gly Lys Leu Val Val Asn Phe 
    130                 135                 140                 


Pro Asn Tyr His Gln Thr Ser Glu Ile Val Gly Asp Lys Leu Val Glu 
145                 150                 155                 160 


Val Ser Thr Ile Gly Gly Val Thr Tyr Glu Arg Val Ser Lys Arg Leu 
                165                 170                 175     


Ala 
    


<210>  3766
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FABP7__Homo_sapiens__NP_001437

<400>  3766

Met Val Glu Ala Phe Cys Ala Thr Trp Lys Leu Thr Asn Ser Gln Asn 
1               5                   10                  15      


Phe Asp Glu Tyr Met Lys Ala Leu Gly Val Gly Phe Ala Thr Arg Gln 
            20                  25                  30          


Val Gly Asn Val Thr Lys Pro Thr Val Ile Ile Ser Gln Glu Gly Asp 
        35                  40                  45              


Lys Val Val Ile Arg Thr Leu Ser Thr Phe Lys Asn Thr Glu Ile Ser 
    50                  55                  60                  


Phe Gln Leu Gly Glu Glu Phe Asp Glu Thr Thr Ala Asp Asp Arg Asn 
65                  70                  75                  80  


Cys Lys Ser Val Val Ser Leu Asp Gly Asp Lys Leu Val His Ile Gln 
                85                  90                  95      


Lys Trp Asp Gly Lys Glu Thr Asn Phe Val Arg Glu Ile Lys Asp Gly 
            100                 105                 110         


Lys Met Val Met Thr Leu Thr Phe Gly Asp Val Val Ala Val Arg His 
        115                 120                 125             


Tyr Glu Lys Ala 
    130         


<210>  3767
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FABP9__Homo_sapiens__NP_001073995

<400>  3767

Met Val Glu Pro Phe Leu Gly Thr Trp Lys Leu Val Ser Ser Glu Asn 
1               5                   10                  15      


Phe Glu Asp Tyr Met Lys Glu Leu Gly Val Asn Phe Ala Ala Arg Asn 
            20                  25                  30          


Met Ala Gly Leu Val Lys Pro Thr Val Thr Ile Ser Val Asp Gly Lys 
        35                  40                  45              


Met Met Thr Ile Arg Thr Glu Ser Ser Phe Gln Asp Thr Lys Ile Ser 
    50                  55                  60                  


Phe Lys Leu Gly Glu Glu Phe Asp Glu Thr Thr Ala Asp Asn Arg Lys 
65                  70                  75                  80  


Val Lys Ser Thr Ile Thr Leu Glu Asn Gly Ser Met Ile His Val Gln 
                85                  90                  95      


Lys Trp Leu Gly Lys Glu Thr Thr Ile Lys Arg Lys Ile Val Asp Glu 
            100                 105                 110         


Lys Met Val Val Glu Cys Lys Met Asn Asn Ile Val Ser Thr Arg Ile 
        115                 120                 125             


Tyr Glu Lys Val 
    130         


<210>  3768
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FADD__Homo_sapiens__NP_003815

<400>  3768

Met Asp Pro Phe Leu Val Leu Leu His Ser Val Ser Ser Ser Leu Ser 
1               5                   10                  15      


Ser Ser Glu Leu Thr Glu Leu Lys Phe Leu Cys Leu Gly Arg Val Gly 
            20                  25                  30          


Lys Arg Lys Leu Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met 
        35                  40                  45              


Leu Leu Glu Gln Asn Asp Leu Glu Pro Gly His Thr Glu Leu Leu Arg 
    50                  55                  60                  


Glu Leu Leu Ala Ser Leu Arg Arg His Asp Leu Leu Arg Arg Val Asp 
65                  70                  75                  80  


Asp Phe Glu Ala Gly Ala Ala Ala Gly Ala Ala Pro Gly Glu Glu Asp 
                85                  90                  95      


Leu Cys Ala Ala Phe Asn Val Ile Cys Asp Asn Val Gly Lys Asp Trp 
            100                 105                 110         


Arg Arg Leu Ala Arg Gln Leu Lys Val Ser Asp Thr Lys Ile Asp Ser 
        115                 120                 125             


Ile Glu Asp Arg Tyr Pro Arg Asn Leu Thr Glu Arg Val Arg Glu Ser 
    130                 135                 140                 


Leu Arg Ile Trp Lys Asn Thr Glu Lys Glu Asn Ala Thr Val Ala His 
145                 150                 155                 160 


Leu Val Gly Ala Leu Arg Ser Cys Gln Met Asn Leu Val Ala Asp Leu 
                165                 170                 175     


Val Gln Glu Val Gln Gln Ala Arg Asp Leu Gln Asn Arg Ser Gly Ala 
            180                 185                 190         


Met Ser Pro Met Ser Trp Asn Ser Asp Ala Ser Thr Ser Glu Ala Ser 
        195                 200                 205             


<210>  3769
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FADS1__Homo_sapiens__NP_037534

<400>  3769

Met Gly Thr Arg Ala Ala Arg Pro Ala Gly Leu Pro Cys Gly Ala Glu 
1               5                   10                  15      


Asn Pro Ala Arg Arg Arg Leu Ala Leu Gly Ala Arg Gln Gln Ile His 
            20                  25                  30          


Ser Trp Ser Pro Arg Thr Pro Ser Thr Arg Leu Thr Ala Pro Ala Gly 
        35                  40                  45              


Pro Ala Arg Gly Val Ala Arg Pro Ala Met Ala Pro Asp Pro Val Ala 
    50                  55                  60                  


Ala Glu Thr Ala Ala Gln Gly Pro Thr Pro Arg Tyr Phe Thr Trp Asp 
65                  70                  75                  80  


Glu Val Ala Gln Arg Ser Gly Cys Glu Glu Arg Trp Leu Val Ile Asp 
                85                  90                  95      


Arg Lys Val Tyr Asn Ile Ser Glu Phe Thr Arg Arg His Pro Gly Gly 
            100                 105                 110         


Ser Arg Val Ile Ser His Tyr Ala Gly Gln Asp Ala Thr Asp Pro Phe 
        115                 120                 125             


Val Ala Phe His Ile Asn Lys Gly Leu Val Lys Lys Tyr Met Asn Ser 
    130                 135                 140                 


Leu Leu Ile Gly Glu Leu Ser Pro Glu Gln Pro Ser Phe Glu Pro Thr 
145                 150                 155                 160 


Lys Asn Lys Glu Leu Thr Asp Glu Phe Arg Glu Leu Arg Ala Thr Val 
                165                 170                 175     


Glu Arg Met Gly Leu Met Lys Ala Asn His Val Phe Phe Leu Leu Tyr 
            180                 185                 190         


Leu Leu His Ile Leu Leu Leu Asp Gly Ala Ala Trp Leu Thr Leu Trp 
        195                 200                 205             


Val Phe Gly Thr Ser Phe Leu Pro Phe Leu Leu Cys Ala Val Leu Leu 
    210                 215                 220                 


Ser Ala Val Gln Ala Gln Ala Gly Trp Leu Gln His Asp Phe Gly His 
225                 230                 235                 240 


Leu Ser Val Phe Ser Thr Ser Lys Trp Asn His Leu Leu His His Phe 
                245                 250                 255     


Val Ile Gly His Leu Lys Gly Ala Pro Ala Ser Trp Trp Asn His Met 
            260                 265                 270         


His Phe Gln His His Ala Lys Pro Asn Cys Phe Arg Lys Asp Pro Asp 
        275                 280                 285             


Ile Asn Met His Pro Phe Phe Phe Ala Leu Gly Lys Ile Leu Ser Val 
    290                 295                 300                 


Glu Leu Gly Lys Gln Lys Lys Lys Tyr Met Pro Tyr Asn His Gln His 
305                 310                 315                 320 


Lys Tyr Phe Phe Leu Ile Gly Pro Pro Ala Leu Leu Pro Leu Tyr Phe 
                325                 330                 335     


Gln Trp Tyr Ile Phe Tyr Phe Val Ile Gln Arg Lys Lys Trp Val Asp 
            340                 345                 350         


Leu Ala Trp Met Ile Thr Phe Tyr Val Arg Phe Phe Leu Thr Tyr Val 
        355                 360                 365             


Pro Leu Leu Gly Leu Lys Ala Phe Leu Gly Leu Phe Phe Ile Val Arg 
    370                 375                 380                 


Phe Leu Glu Ser Asn Trp Phe Val Trp Val Thr Gln Met Asn His Ile 
385                 390                 395                 400 


Pro Met His Ile Asp His Asp Arg Asn Met Asp Trp Val Ser Thr Gln 
                405                 410                 415     


Leu Gln Ala Thr Cys Asn Val His Lys Ser Ala Phe Asn Asp Trp Phe 
            420                 425                 430         


Ser Gly His Leu Asn Phe Gln Ile Glu His His Leu Phe Pro Thr Met 
        435                 440                 445             


Pro Arg His Asn Tyr His Lys Val Ala Pro Leu Val Gln Ser Leu Cys 
    450                 455                 460                 


Ala Lys His Gly Ile Glu Tyr Gln Ser Lys Pro Leu Leu Ser Ala Phe 
465                 470                 475                 480 


Ala Asp Ile Ile His Ser Leu Lys Glu Ser Gly Gln Leu Trp Leu Asp 
                485                 490                 495     


Ala Tyr Leu His Gln 
            500     


<210>  3770
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FADS2__Homo_sapiens__NP_001268430

<400>  3770

Met His Gly Arg Glu Ala Gly Pro Phe Val Cys Val Cys Val Leu Leu 
1               5                   10                  15      


Ala Ser Ile Pro Thr Pro Gln Thr Pro Leu Leu Gln Ala Ser Leu Pro 
            20                  25                  30          


Pro Phe His Pro Ala Ser Ala Gly His Pro Ile Thr Gly Gln Gln Asp 
        35                  40                  45              


Ala Phe Arg Ala Phe His Pro Asp Leu Glu Phe Val Gly Lys Phe Leu 
    50                  55                  60                  


Lys Pro Leu Leu Ile Gly Glu Leu Ala Pro Glu Glu Pro Ser Gln Asp 
65                  70                  75                  80  


His Gly Lys Asn Ser Lys Ile Thr Glu Asp Phe Arg Ala Leu Arg Lys 
                85                  90                  95      


Thr Ala Glu Asp Met Asn Leu Phe Lys Thr Asn His Val Phe Phe Leu 
            100                 105                 110         


Leu Leu Leu Ala His Ile Ile Ala Leu Glu Ser Ile Ala Trp Phe Thr 
        115                 120                 125             


Val Phe Tyr Phe Gly Asn Gly Trp Ile Pro Thr Leu Ile Thr Ala Phe 
    130                 135                 140                 


Val Leu Ala Thr Ser Gln Ala Gln Ala Gly Trp Leu Gln His Asp Tyr 
145                 150                 155                 160 


Gly His Leu Ser Val Tyr Arg Lys Pro Lys Trp Asn His Leu Val His 
                165                 170                 175     


Lys Phe Val Ile Gly His Leu Lys Gly Ala Ser Ala Asn Trp Trp Asn 
            180                 185                 190         


His Arg His Phe Gln His His Ala Lys Pro Asn Ile Phe His Lys Asp 
        195                 200                 205             


Pro Asp Val Asn Met Leu His Val Phe Val Leu Gly Glu Trp Gln Pro 
    210                 215                 220                 


Ile Glu Tyr Gly Lys Lys Lys Leu Lys Tyr Leu Pro Tyr Asn His Gln 
225                 230                 235                 240 


His Glu Tyr Phe Phe Leu Ile Gly Pro Pro Leu Leu Ile Pro Met Tyr 
                245                 250                 255     


Phe Gln Tyr Gln Ile Ile Met Thr Met Ile Val His Lys Asn Trp Val 
            260                 265                 270         


Asp Leu Ala Trp Ala Val Ser Tyr Tyr Ile Arg Phe Phe Ile Thr Tyr 
        275                 280                 285             


Ile Pro Phe Tyr Gly Ile Leu Gly Ala Leu Leu Phe Leu Asn Phe Ile 
    290                 295                 300                 


Arg Phe Leu Glu Ser His Trp Phe Val Trp Val Thr Gln Met Asn His 
305                 310                 315                 320 


Ile Val Met Glu Ile Asp Gln Glu Ala Tyr Arg Asp Trp Phe Ser Ser 
                325                 330                 335     


Gln Leu Thr Ala Thr Cys Asn Val Glu Gln Ser Phe Phe Asn Asp Trp 
            340                 345                 350         


Phe Ser Gly His Leu Asn Phe Gln Ile Glu His His Leu Phe Pro Thr 
        355                 360                 365             


Met Pro Arg His Asn Leu His Lys Ile Ala Pro Leu Val Lys Ser Leu 
    370                 375                 380                 


Cys Ala Lys His Gly Ile Glu Tyr Gln Glu Lys Pro Leu Leu Arg Ala 
385                 390                 395                 400 


Leu Leu Asp Ile Ile Arg Ser Leu Lys Lys Ser Gly Lys Leu Trp Leu 
                405                 410                 415     


Asp Ala Tyr Leu His Lys 
            420         


<210>  3771
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FADS3__Homo_sapiens__NP_068373

<400>  3771

Met Gly Gly Val Gly Glu Pro Gly Pro Arg Glu Gly Pro Ala Gln Pro 
1               5                   10                  15      


Gly Ala Pro Leu Pro Thr Phe Cys Trp Glu Gln Ile Arg Ala His Asp 
            20                  25                  30          


Gln Pro Gly Asp Lys Trp Leu Val Ile Glu Arg Arg Val Tyr Asp Ile 
        35                  40                  45              


Ser Arg Trp Ala Gln Arg His Pro Gly Gly Ser Arg Leu Ile Gly His 
    50                  55                  60                  


His Gly Ala Glu Asp Ala Thr Asp Ala Phe Arg Ala Phe His Gln Asp 
65                  70                  75                  80  


Leu Asn Phe Val Arg Lys Phe Leu Gln Pro Leu Leu Ile Gly Glu Leu 
                85                  90                  95      


Ala Pro Glu Glu Pro Ser Gln Asp Gly Pro Leu Asn Ala Gln Leu Val 
            100                 105                 110         


Glu Asp Phe Arg Ala Leu His Gln Ala Ala Glu Asp Met Lys Leu Phe 
        115                 120                 125             


Asp Ala Ser Pro Thr Phe Phe Ala Phe Leu Leu Gly His Ile Leu Ala 
    130                 135                 140                 


Met Glu Val Leu Ala Trp Leu Leu Ile Tyr Leu Leu Gly Pro Gly Trp 
145                 150                 155                 160 


Val Pro Ser Ala Leu Ala Ala Phe Ile Leu Ala Ile Ser Gln Ala Gln 
                165                 170                 175     


Ser Trp Cys Leu Gln His Asp Leu Gly His Ala Ser Ile Phe Lys Lys 
            180                 185                 190         


Ser Trp Trp Asn His Val Ala Gln Lys Phe Val Met Gly Gln Leu Lys 
        195                 200                 205             


Gly Phe Ser Ala His Trp Trp Asn Phe Arg His Phe Gln His His Ala 
    210                 215                 220                 


Lys Pro Asn Ile Phe His Lys Asp Pro Asp Val Thr Val Ala Pro Val 
225                 230                 235                 240 


Phe Leu Leu Gly Glu Ser Ser Val Glu Tyr Gly Lys Lys Lys Arg Arg 
                245                 250                 255     


Tyr Leu Pro Tyr Asn Gln Gln His Leu Tyr Phe Phe Leu Ile Gly Pro 
            260                 265                 270         


Pro Leu Leu Thr Leu Val Asn Phe Glu Val Glu Asn Leu Ala Tyr Met 
        275                 280                 285             


Leu Val Cys Met Gln Trp Ala Asp Leu Leu Trp Ala Ala Ser Phe Tyr 
    290                 295                 300                 


Ala Arg Phe Phe Leu Ser Tyr Leu Pro Phe Tyr Gly Val Pro Gly Val 
305                 310                 315                 320 


Leu Leu Phe Phe Val Ala Val Arg Val Leu Glu Ser His Trp Phe Val 
                325                 330                 335     


Trp Ile Thr Gln Met Asn His Ile Pro Lys Glu Ile Gly His Glu Lys 
            340                 345                 350         


His Arg Asp Trp Val Ser Ser Gln Leu Ala Ala Thr Cys Asn Val Glu 
        355                 360                 365             


Pro Ser Leu Phe Thr Asn Trp Phe Ser Gly His Leu Asn Phe Gln Ile 
    370                 375                 380                 


Glu His His Leu Phe Pro Arg Met Pro Arg His Asn Tyr Ser Arg Val 
385                 390                 395                 400 


Ala Pro Leu Val Lys Ser Leu Cys Ala Lys His Gly Leu Ser Tyr Glu 
                405                 410                 415     


Val Lys Pro Phe Leu Thr Ala Leu Val Asp Ile Val Arg Ser Leu Lys 
            420                 425                 430         


Lys Ser Gly Asp Ile Trp Leu Asp Ala Tyr Leu His Gln 
        435                 440                 445 


<210>  3772
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAF2__Homo_sapiens__NP_055428

<400>  3772

Met Ala Ala Pro Glu Glu Arg Asp Leu Thr Gln Glu Gln Thr Glu Lys 
1               5                   10                  15      


Leu Leu Gln Phe Gln Asp Leu Thr Gly Ile Glu Ser Met Asp Gln Cys 
            20                  25                  30          


Arg His Thr Leu Glu Gln His Asn Trp Asn Ile Glu Ala Ala Val Gln 
        35                  40                  45              


Asp Arg Leu Asn Glu Gln Glu Gly Val Pro Ser Val Phe Asn Pro Pro 
    50                  55                  60                  


Pro Ser Arg Pro Leu Gln Val Asn Thr Ala Asp His Arg Ile Tyr Ser 
65                  70                  75                  80  


Tyr Val Val Ser Arg Pro Gln Pro Arg Gly Leu Leu Gly Trp Gly Tyr 
                85                  90                  95      


Tyr Leu Ile Met Leu Pro Phe Arg Phe Thr Tyr Tyr Thr Ile Leu Asp 
            100                 105                 110         


Ile Phe Arg Phe Ala Leu Arg Phe Ile Arg Pro Asp Pro Arg Ser Arg 
        115                 120                 125             


Val Thr Asp Pro Val Gly Asp Ile Val Ser Phe Met His Ser Phe Glu 
    130                 135                 140                 


Glu Lys Tyr Gly Arg Ala His Pro Val Phe Tyr Gln Gly Thr Tyr Ser 
145                 150                 155                 160 


Gln Ala Leu Asn Asp Ala Lys Arg Glu Leu Arg Phe Leu Leu Val Tyr 
                165                 170                 175     


Leu His Gly Asp Asp His Gln Asp Ser Asp Glu Phe Cys Arg Asn Thr 
            180                 185                 190         


Leu Cys Ala Pro Glu Val Ile Ser Leu Ile Asn Thr Arg Met Leu Phe 
        195                 200                 205             


Trp Ala Cys Ser Thr Asn Lys Pro Glu Gly Tyr Arg Val Ser Gln Ala 
    210                 215                 220                 


Leu Arg Glu Asn Thr Tyr Pro Phe Leu Ala Met Ile Met Leu Lys Asp 
225                 230                 235                 240 


Arg Arg Met Thr Val Val Gly Arg Leu Glu Gly Leu Ile Gln Pro Asp 
                245                 250                 255     


Asp Leu Ile Asn Gln Leu Thr Phe Ile Met Asp Ala Asn Gln Thr Tyr 
            260                 265                 270         


Leu Val Ser Glu Arg Leu Glu Arg Glu Glu Arg Asn Gln Thr Gln Val 
        275                 280                 285             


Leu Arg Gln Gln Gln Asp Glu Ala Tyr Leu Ala Ser Leu Arg Ala Asp 
    290                 295                 300                 


Gln Glu Lys Glu Arg Lys Lys Arg Glu Glu Arg Glu Arg Lys Arg Arg 
305                 310                 315                 320 


Lys Glu Glu Glu Val Gln Gln Gln Lys Leu Ala Glu Glu Arg Arg Arg 
                325                 330                 335     


Gln Asn Leu Gln Glu Glu Lys Glu Arg Lys Leu Glu Cys Leu Pro Pro 
            340                 345                 350         


Glu Pro Ser Pro Asp Asp Pro Glu Ser Val Lys Ile Ile Phe Lys Leu 
        355                 360                 365             


Pro Asn Asp Ser Arg Val Glu Arg Arg Phe His Phe Ser Gln Ser Leu 
    370                 375                 380                 


Thr Val Ile His Asp Phe Leu Phe Ser Leu Lys Glu Ser Pro Glu Lys 
385                 390                 395                 400 


Phe Gln Ile Glu Ala Asn Phe Pro Arg Arg Val Leu Pro Cys Ile Pro 
                405                 410                 415     


Ser Glu Glu Trp Pro Asn Pro Pro Thr Leu Gln Glu Ala Gly Leu Ser 
            420                 425                 430         


His Thr Glu Val Leu Phe Val Gln Asp Leu Thr Asp Glu 
        435                 440                 445 


<210>  3773
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAHD2A__Homo_sapiens__NP_057128

<400>  3773

Met Leu Val Ser Gly Arg Arg Arg Leu Leu Thr Val Leu Leu Gln Ala 
1               5                   10                  15      


Gln Lys Trp Pro Phe Gln Pro Ser Arg Asp Met Arg Leu Val Gln Phe 
            20                  25                  30          


Arg Ala Pro His Leu Val Gly Pro His Leu Gly Leu Glu Thr Gly Asn 
        35                  40                  45              


Gly Gly Gly Val Ile Asn Leu Asn Ala Phe Asp Pro Thr Leu Pro Lys 
    50                  55                  60                  


Thr Met Thr Gln Phe Leu Glu Gln Gly Glu Ala Thr Leu Ser Val Ala 
65                  70                  75                  80  


Arg Arg Ala Leu Ala Ala Gln Leu Pro Val Leu Pro Arg Ser Glu Val 
                85                  90                  95      


Thr Phe Leu Ala Pro Val Thr Arg Pro Asp Lys Val Val Cys Val Gly 
            100                 105                 110         


Met Asn Tyr Val Asp His Cys Lys Glu Gln Asn Val Pro Val Pro Lys 
        115                 120                 125             


Glu Pro Ile Ile Phe Ser Lys Phe Ala Ser Ser Ile Val Gly Pro Tyr 
    130                 135                 140                 


Asp Glu Val Val Leu Pro Pro Gln Ser Gln Glu Val Asp Trp Glu Val 
145                 150                 155                 160 


Glu Leu Ala Val Val Ile Gly Lys Lys Gly Lys His Ile Lys Ala Thr 
                165                 170                 175     


Asp Ala Met Ala His Val Ala Gly Phe Thr Val Ala His Asp Val Ser 
            180                 185                 190         


Ala Arg Asp Trp Gln Met Arg Arg Asn Gly Lys Gln Trp Leu Leu Gly 
        195                 200                 205             


Lys Thr Phe Asp Thr Phe Cys Pro Leu Gly Pro Ala Leu Val Thr Lys 
    210                 215                 220                 


Asp Ser Val Ala Asp Pro His Asn Leu Lys Ile Cys Cys Arg Val Asn 
225                 230                 235                 240 


Gly Glu Val Val Gln Ser Gly Asn Thr Asn Gln Met Val Phe Lys Thr 
                245                 250                 255     


Glu Asp Leu Ile Ala Trp Val Ser Gln Phe Val Thr Phe Tyr Pro Gly 
            260                 265                 270         


Asp Val Ile Leu Thr Gly Thr Pro Pro Gly Val Gly Val Phe Arg Lys 
        275                 280                 285             


Pro Pro Val Phe Leu Lys Lys Gly Asp Glu Val Gln Cys Glu Ile Glu 
    290                 295                 300                 


Glu Leu Gly Val Ile Ile Asn Lys Val Val 
305                 310                 


<210>  3774
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAH__Homo_sapiens__NP_000128

<400>  3774

Met Ser Phe Ile Pro Val Ala Glu Asp Ser Asp Phe Pro Ile His Asn 
1               5                   10                  15      


Leu Pro Tyr Gly Val Phe Ser Thr Arg Gly Asp Pro Arg Pro Arg Ile 
            20                  25                  30          


Gly Val Ala Ile Gly Asp Gln Ile Leu Asp Leu Ser Ile Ile Lys His 
        35                  40                  45              


Leu Phe Thr Gly Pro Val Leu Ser Lys His Gln Asp Val Phe Asn Gln 
    50                  55                  60                  


Pro Thr Leu Asn Ser Phe Met Gly Leu Gly Gln Ala Ala Trp Lys Glu 
65                  70                  75                  80  


Ala Arg Val Phe Leu Gln Asn Leu Leu Ser Val Ser Gln Ala Arg Leu 
                85                  90                  95      


Arg Asp Asp Thr Glu Leu Arg Lys Cys Ala Phe Ile Ser Gln Ala Ser 
            100                 105                 110         


Ala Thr Met His Leu Pro Ala Thr Ile Gly Asp Tyr Thr Asp Phe Tyr 
        115                 120                 125             


Ser Ser Arg Gln His Ala Thr Asn Val Gly Ile Met Phe Arg Asp Lys 
    130                 135                 140                 


Glu Asn Ala Leu Met Pro Asn Trp Leu His Leu Pro Val Gly Tyr His 
145                 150                 155                 160 


Gly Arg Ala Ser Ser Val Val Val Ser Gly Thr Pro Ile Arg Arg Pro 
                165                 170                 175     


Met Gly Gln Met Lys Pro Asp Asp Ser Lys Pro Pro Val Tyr Gly Ala 
            180                 185                 190         


Cys Lys Leu Leu Asp Met Glu Leu Glu Met Ala Phe Phe Val Gly Pro 
        195                 200                 205             


Gly Asn Arg Leu Gly Glu Pro Ile Pro Ile Ser Lys Ala His Glu His 
    210                 215                 220                 


Ile Phe Gly Met Val Leu Met Asn Asp Trp Ser Ala Arg Asp Ile Gln 
225                 230                 235                 240 


Lys Trp Glu Tyr Val Pro Leu Gly Pro Phe Leu Gly Lys Ser Phe Gly 
                245                 250                 255     


Thr Thr Val Ser Pro Trp Val Val Pro Met Asp Ala Leu Met Pro Phe 
            260                 265                 270         


Ala Val Pro Asn Pro Lys Gln Asp Pro Arg Pro Leu Pro Tyr Leu Cys 
        275                 280                 285             


His Asp Glu Pro Tyr Thr Phe Asp Ile Asn Leu Ser Val Asn Leu Lys 
    290                 295                 300                 


Gly Glu Gly Met Ser Gln Ala Ala Thr Ile Cys Lys Ser Asn Phe Lys 
305                 310                 315                 320 


Tyr Met Tyr Trp Thr Met Leu Gln Gln Leu Thr His His Ser Val Asn 
                325                 330                 335     


Gly Cys Asn Leu Arg Pro Gly Asp Leu Leu Ala Ser Gly Thr Ile Ser 
            340                 345                 350         


Gly Pro Glu Pro Glu Asn Phe Gly Ser Met Leu Glu Leu Ser Trp Lys 
        355                 360                 365             


Gly Thr Lys Pro Ile Asp Leu Gly Asn Gly Gln Thr Arg Lys Phe Leu 
    370                 375                 380                 


Leu Asp Gly Asp Glu Val Ile Ile Thr Gly Tyr Cys Gln Gly Asp Gly 
385                 390                 395                 400 


Tyr Arg Ile Gly Phe Gly Gln Cys Ala Gly Lys Val Leu Pro Ala Leu 
                405                 410                 415     


Leu Pro Ser 
            


<210>  3775
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAIM2__Homo_sapiens__NP_036438

<400>  3775

Met Thr Gln Gly Lys Leu Ser Val Ala Asn Lys Ala Pro Gly Thr Glu 
1               5                   10                  15      


Gly Gln Gln Gln Val His Gly Glu Lys Lys Glu Ala Pro Ala Val Pro 
            20                  25                  30          


Ser Ala Pro Pro Ser Tyr Glu Glu Ala Thr Ser Gly Glu Gly Met Lys 
        35                  40                  45              


Ala Gly Ala Phe Pro Pro Ala Pro Thr Ala Val Pro Leu His Pro Ser 
    50                  55                  60                  


Trp Ala Tyr Val Asp Pro Ser Ser Ser Ser Ser Tyr Asp Asn Gly Phe 
65                  70                  75                  80  


Pro Thr Gly Asp His Glu Leu Phe Thr Thr Phe Ser Trp Asp Asp Gln 
                85                  90                  95      


Lys Val Arg Arg Val Phe Val Arg Lys Val Tyr Thr Ile Leu Leu Ile 
            100                 105                 110         


Gln Leu Leu Val Thr Leu Ala Val Val Ala Leu Phe Thr Phe Cys Asp 
        115                 120                 125             


Pro Val Lys Asp Tyr Val Gln Ala Asn Pro Gly Trp Tyr Trp Ala Ser 
    130                 135                 140                 


Tyr Ala Val Phe Phe Ala Thr Tyr Leu Thr Leu Ala Cys Cys Ser Gly 
145                 150                 155                 160 


Pro Arg Arg His Phe Pro Trp Asn Leu Ile Leu Leu Thr Val Phe Thr 
                165                 170                 175     


Leu Ser Met Ala Tyr Leu Thr Gly Met Leu Ser Ser Tyr Tyr Asn Thr 
            180                 185                 190         


Thr Ser Val Leu Leu Cys Leu Gly Ile Thr Ala Leu Val Cys Leu Ser 
        195                 200                 205             


Val Thr Val Phe Ser Phe Gln Thr Lys Phe Asp Phe Thr Ser Cys Gln 
    210                 215                 220                 


Gly Val Leu Phe Val Leu Leu Met Thr Leu Phe Phe Ser Gly Leu Ile 
225                 230                 235                 240 


Leu Ala Ile Leu Leu Pro Phe Gln Tyr Val Pro Trp Leu His Ala Val 
                245                 250                 255     


Tyr Ala Ala Leu Gly Ala Gly Val Phe Thr Leu Phe Leu Ala Leu Asp 
            260                 265                 270         


Thr Gln Leu Leu Met Gly Asn Arg Arg His Ser Leu Ser Pro Glu Glu 
        275                 280                 285             


Tyr Ile Phe Gly Ala Leu Asn Ile Tyr Leu Asp Ile Ile Tyr Ile Phe 
    290                 295                 300                 


Thr Phe Phe Leu Gln Leu Phe Gly Thr Asn Arg Glu 
305                 310                 315     


<210>  3776
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAIM3__Homo_sapiens__NP_001135945

<400>  3776

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Glu Tyr Glu Pro 
1               5                   10                  15      


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
            20                  25                  30          


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
        35                  40                  45              


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
    50                  55                  60                  


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
65                  70                  75                  80  


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
                85                  90                  95      


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
            100                 105                 110         


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
        115                 120                 125             


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
    130                 135                 140                 


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
145                 150                 155                 160 


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
                165                 170                 175     


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
            180                 185                 190         


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
        195                 200                 205             


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
    210                 215                 220                 


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
225                 230                 235                 240 


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
                245                 250                 255     


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
            260                 265                 270         


Tyr Ile Asn Val Pro Ala 
        275             


<210>  3777
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM102A__Homo_sapiens__NP_001030331

<400>  3777

Met Ala Phe Leu Met Lys Lys Lys Lys Phe Lys Phe Gln Thr Thr Phe 
1               5                   10                  15      


Thr Leu Glu Glu Leu Thr Ala Val Pro Phe Val Asn Gly Val Leu Phe 
            20                  25                  30          


Cys Lys Val Arg Leu Leu Asp Gly Gly Asp Phe Val Ser Leu Ser Ser 
        35                  40                  45              


Arg Glu Glu Val Gln Glu Asn Cys Val Arg Trp Arg Lys Arg Phe Thr 
    50                  55                  60                  


Phe Val Cys Lys Met Ser Ala Asn Pro Ala Thr Gly Leu Leu Asp Pro 
65                  70                  75                  80  


Cys Val Phe Arg Val Ser Val Arg Lys Glu Leu Lys Gly Gly Lys Ala 
                85                  90                  95      


Tyr Ser Lys Leu Gly Phe Ala Asp Leu Asn Leu Ala Glu Phe Ala Gly 
            100                 105                 110         


Ser Gly Ser Thr Val Arg Cys Cys Leu Leu Glu Gly Tyr Asp Thr Lys 
        115                 120                 125             


Asn Thr Arg Gln Asp Asn Ser Ile Leu Lys Val Thr Ile Gly Met Phe 
    130                 135                 140                 


Leu Leu Ser Gly Asp Pro Cys Phe Lys Thr Pro Pro Ser Thr Ala Lys 
145                 150                 155                 160 


Ser Ile Ser Ile Pro Gly Gln Asp Ser Ser Leu Gln Leu Thr Cys Lys 
                165                 170                 175     


Gly Gly Gly Thr Ser Ser Gly Gly Ser Ser Thr Asn Ser Leu Thr Gly 
            180                 185                 190         


Ser Arg Pro Pro Lys Ala Arg Pro Thr Ile Leu Ser Ser Gly Leu Pro 
        195                 200                 205             


Glu Glu Pro Asp Gln Asn Leu Ser Ser Pro Glu Glu Val Phe His Ser 
    210                 215                 220                 


Gly His Ser Arg Asn Ser Ser Tyr Ala Ser Gln Gln Ser Lys Ile Ser 
225                 230                 235                 240 


Gly Tyr Ser Thr Glu His Ser Arg Ser Ser Ser Leu Ser Asp Leu Thr 
                245                 250                 255     


His Arg Arg Asn Thr Ser Thr Ser Ser Ser Ala Ser Gly Gly Leu Gly 
            260                 265                 270         


Met Thr Val Glu Gly Pro Glu Gly Ser Glu Arg Glu His Arg Pro Pro 
        275                 280                 285             


Glu Lys Pro Pro Arg Pro Pro Arg Pro Leu His Leu Ser Asp Arg Ser 
    290                 295                 300                 


Phe Arg Arg Lys Lys Asp Ser Val Glu Ser His Pro Thr Trp Val Asp 
305                 310                 315                 320 


Asp Thr Arg Ile Asp Ala Asp Ala Ile Val Glu Lys Ile Val Gln Ser 
                325                 330                 335     


Gln Asp Phe Thr Asp Gly Ser Asn Thr Glu Asp Ser Asn Leu Arg Leu 
            340                 345                 350         


Phe Val Ser Arg Asp Gly Ser Ala Thr Leu Ser Gly Ile Gln Leu Ala 
        355                 360                 365             


Thr Arg Val Ser Ser Gly Val Tyr Glu Pro Val Val Ile Glu Ser His 
    370                 375                 380                 


<210>  3778
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM103A1__Homo_sapiens__NP_113640

<400>  3778

Met Thr Asp Thr Ala Glu Ala Val Pro Lys Phe Glu Glu Met Phe Ala 
1               5                   10                  15      


Ser Arg Phe Thr Glu Asn Asp Lys Glu Tyr Gln Glu Tyr Leu Lys Arg 
            20                  25                  30          


Pro Pro Glu Ser Pro Pro Ile Val Glu Glu Trp Asn Ser Arg Ala Gly 
        35                  40                  45              


Gly Asn Gln Arg Asn Arg Gly Asn Arg Leu Gln Asp Asn Arg Gln Phe 
    50                  55                  60                  


Arg Gly Arg Asp Asn Arg Trp Gly Trp Pro Ser Asp Asn Arg Ser Asn 
65                  70                  75                  80  


Gln Trp His Gly Arg Ser Trp Gly Asn Asn Tyr Pro Gln His Arg Gln 
                85                  90                  95      


Glu Pro Tyr Tyr Pro Gln Gln Tyr Gly His Tyr Gly Tyr Asn Gln Arg 
            100                 105                 110         


Pro Pro Tyr Gly Tyr Tyr 
        115             


<210>  3779
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM105A__Homo_sapiens__NP_061891

<400>  3779

Met Ala Ala Thr Arg Ser Pro Thr Arg Ala Arg Glu Arg Glu Arg Ser 
1               5                   10                  15      


Gly Ala Pro Ala Ala Gly Ser Asp Gln Val His Ser Trp Met Leu Ala 
            20                  25                  30          


Thr Ser Gln Ala Leu Asp Thr Val Trp Arg Met Ala Lys Gly Phe Val 
        35                  40                  45              


Met Leu Ala Val Ser Phe Leu Val Ala Ala Ile Cys Tyr Phe Arg Arg 
    50                  55                  60                  


Leu His Leu Tyr Ser Gly His Lys Leu Lys Trp Trp Ile Gly Tyr Leu 
65                  70                  75                  80  


Gln Arg Lys Phe Lys Arg Asn Leu Ser Val Glu Ala Glu Val Asp Leu 
                85                  90                  95      


Leu Ser Tyr Cys Ala Arg Glu Trp Lys Gly Glu Thr Pro Arg Asn Lys 
            100                 105                 110         


Leu Met Arg Lys Ala Tyr Glu Glu Leu Phe Trp Arg His His Ile Lys 
        115                 120                 125             


Cys Val Arg Gln Val Arg Arg Asp Asn Tyr Asp Ala Leu Arg Ser Val 
    130                 135                 140                 


Leu Phe Gln Ile Phe Ser Gln Gly Ile Ser Phe Pro Ser Trp Met Lys 
145                 150                 155                 160 


Glu Lys Asp Ile Val Lys Leu Pro Glu Lys Leu Leu Phe Ser Gln Gly 
                165                 170                 175     


Cys Asn Trp Ile Gln Gln Tyr Ser Phe Gly Pro Glu Lys Tyr Thr Gly 
            180                 185                 190         


Ser Asn Val Phe Gly Lys Leu Arg Lys Tyr Val Glu Leu Leu Lys Thr 
        195                 200                 205             


Gln Trp Thr Glu Phe Asn Gly Ile Arg Asp Tyr His Lys Arg Gly Ser 
    210                 215                 220                 


Met Cys Asn Thr Leu Phe Ser Asp Ala Ile Leu Glu Tyr Lys Leu Tyr 
225                 230                 235                 240 


Glu Ala Leu Lys Phe Ile Met Leu Tyr Gln Val Thr Glu Val Tyr Glu 
                245                 250                 255     


Gln Met Lys Thr Lys Lys Val Ile Pro Ser Leu Phe Arg Leu Leu Phe 
            260                 265                 270         


Ser Arg Glu Thr Ser Ser Asp Pro Leu Ser Phe Met Met Asn His Leu 
        275                 280                 285             


Asn Ser Val Gly Asp Thr Cys Gly Leu Glu Gln Ile Asp Met Phe Ile 
    290                 295                 300                 


Leu Gly Tyr Ser Leu Glu Val Lys Ile Lys Val Phe Arg Leu Phe Lys 
305                 310                 315                 320 


Phe Asn Ser Arg Asp Phe Glu Val Cys Tyr Pro Glu Glu Pro Leu Arg 
                325                 330                 335     


Asp Trp Pro Glu Ile Ser Leu Leu Thr Glu Asn Asp Arg His Tyr His 
            340                 345                 350         


Ile Pro Val Phe 
        355     


<210>  3780
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM107A__Homo_sapiens__NP_001269642

<400>  3780

Met Ala Gln Arg Leu Gly Glu Trp Ala Arg Gly Pro Ser Asp Ala Thr 
1               5                   10                  15      


Gly Leu Tyr Arg Ala Val Leu Leu Arg Ser Ala Ala Met Tyr Ser Glu 
            20                  25                  30          


Ile Gln Arg Glu Arg Ala Asp Ile Gly Gly Leu Met Ala Arg Pro Glu 
        35                  40                  45              


Tyr Arg Glu Trp Asn Pro Glu Leu Ile Lys Pro Lys Lys Leu Leu Asn 
    50                  55                  60                  


Pro Val Lys Ala Ser Arg Ser His Gln Glu Leu His Arg Glu Leu Leu 
65                  70                  75                  80  


Met Asn His Arg Arg Gly Leu Gly Val Asp Ser Lys Pro Glu Leu Gln 
                85                  90                  95      


Arg Val Leu Glu His Arg Arg Arg Asn Gln Leu Ile Lys Lys Lys Lys 
            100                 105                 110         


Glu Glu Leu Glu Ala Lys Arg Leu Gln Cys Pro Phe Glu Gln Glu Leu 
        115                 120                 125             


Leu Arg Arg Gln Gln Arg Leu Asn Gln Leu Glu Lys Pro Pro Glu Lys 
    130                 135                 140                 


Glu Glu Asp His Ala Pro Glu Phe Ile Lys Val Arg Glu Asn Leu Arg 
145                 150                 155                 160 


Arg Ile Ala Thr Leu Thr Ser Glu Glu Arg Glu Leu 
                165                 170         


<210>  3781
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM107B__Homo_sapiens__NP_001269625

<400>  3781

Met Ala Glu Pro Asp Tyr Ile Glu Asp Asp Asn Pro Glu Leu Ile Arg 
1               5                   10                  15      


Pro Gln Lys Leu Ile Asn Pro Val Lys Thr Ser Arg Asn His Gln Asp 
            20                  25                  30          


Leu His Arg Glu Leu Leu Met Asn Gln Lys Arg Gly Leu Ala Pro Gln 
        35                  40                  45              


Asn Lys Pro Glu Leu Gln Lys Val Met Glu Lys Arg Lys Arg Asp Gln 
    50                  55                  60                  


Val Ile Lys Gln Lys Glu Glu Glu Ala Gln Lys Lys Lys Ser Asp Leu 
65                  70                  75                  80  


Glu Ile Glu Leu Leu Lys Arg Gln Gln Lys Leu Glu Gln Leu Glu Leu 
                85                  90                  95      


Glu Lys Gln Lys Leu Gln Glu Glu Gln Glu Asn Ala Pro Glu Phe Val 
            100                 105                 110         


Lys Val Lys Gly Asn Leu Arg Arg Thr Gly Gln Glu Val Ala Gln Ala 
        115                 120                 125             


Gln Glu Ser 
    130     


<210>  3782
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM109A__Homo_sapiens__NP_001171467

<400>  3782

Met Ala Pro Gly Ser Pro Pro Gly Pro Ala Ile Ala Thr Met Lys Leu 
1               5                   10                  15      


Asn Glu Arg Ser Leu Ala Phe Tyr Ala Thr Cys Asp Ala Pro Val Asp 
            20                  25                  30          


Asn Ala Gly Phe Leu Tyr Lys Lys Gly Gly Arg His Ala Ala Tyr His 
        35                  40                  45              


Arg Arg Trp Phe Val Leu Arg Gly Asn Met Leu Phe Tyr Phe Glu Asp 
    50                  55                  60                  


Ala Ala Ser Arg Glu Pro Val Gly Val Ile Ile Leu Glu Gly Cys Thr 
65                  70                  75                  80  


Val Glu Leu Val Glu Ala Ala Glu Glu Phe Ala Phe Ala Val Arg Phe 
                85                  90                  95      


Ala Gly Thr Arg Ala Arg Thr Tyr Val Leu Ala Ala Glu Ser Gln Asp 
            100                 105                 110         


Ala Met Glu Gly Trp Val Lys Ala Leu Ser Arg Ala Ser Phe Asp Tyr 
        115                 120                 125             


Leu Arg Leu Val Val Arg Glu Leu Glu Gln Gln Leu Ala Ala Val Arg 
    130                 135                 140                 


Gly Gly Gly Gly Met Ala Leu Pro Gln Pro Gln Pro Gln Ser Leu Pro 
145                 150                 155                 160 


Leu Pro Pro Ser Leu Pro Ser Ala Leu Ala Pro Val Pro Ser Leu Pro 
                165                 170                 175     


Ser Ala Pro Ala Pro Val Pro Ala Leu Pro Leu Pro Arg Arg Pro Ser 
            180                 185                 190         


Ala Leu Pro Pro Lys Glu Asn Gly Cys Ala Val Trp Ser Thr Glu Ala 
        195                 200                 205             


Thr Phe Arg Pro Gly Pro Glu Pro Pro Pro Pro Pro Pro Arg Arg Arg 
    210                 215                 220                 


Ala Ser Ala Pro His Gly Pro Leu Asp Met Ala Pro Phe Ala Arg Leu 
225                 230                 235                 240 


His Glu Cys Tyr Gly Gln Glu Ile Arg Ala Leu Arg Gly Gln Trp Leu 
                245                 250                 255     


Ser Ser Arg Val Gln Pro 
            260         


<210>  3783
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM110A__Homo_sapiens__NP_001276075

<400>  3783

Met Pro Val His Thr Leu Ser Pro Gly Ala Pro Ser Ala Pro Ala Leu 
1               5                   10                  15      


Pro Cys Arg Leu Arg Thr Arg Val Pro Gly Tyr Leu Leu Arg Gly Pro 
            20                  25                  30          


Ala Asp Gly Gly Ala Arg Lys Pro Ser Ala Val Glu Arg Leu Glu Ala 
        35                  40                  45              


Asp Lys Ala Lys Tyr Val Lys Ser Leu His Val Ala Asn Thr Arg Gln 
    50                  55                  60                  


Glu Pro Val Gln Pro Leu Leu Ser Lys Gln Pro Leu Phe Ser Pro Glu 
65                  70                  75                  80  


Thr Arg Arg Thr Val Leu Thr Pro Ser Arg Arg Ala Leu Pro Gly Pro 
                85                  90                  95      


Cys Arg Arg Pro Gln Leu Asp Leu Asp Ile Leu Ser Ser Leu Ile Asp 
            100                 105                 110         


Leu Cys Asp Ser Pro Val Ser Pro Ala Glu Ala Ser Arg Thr Pro Gly 
        115                 120                 125             


Arg Ala Glu Gly Ala Gly Arg Pro Pro Pro Ala Thr Pro Pro Arg Pro 
    130                 135                 140                 


Pro Pro Ser Thr Ser Ala Val Arg Arg Val Asp Val Arg Pro Leu Pro 
145                 150                 155                 160 


Ala Ser Pro Ala Arg Pro Cys Pro Ser Pro Gly Pro Ala Ala Ala Ser 
                165                 170                 175     


Ser Pro Ala Arg Pro Pro Gly Leu Gln Arg Ser Lys Ser Asp Leu Ser 
            180                 185                 190         


Glu Arg Phe Ser Arg Ala Ala Ala Asp Leu Glu Arg Phe Phe Asn Phe 
        195                 200                 205             


Cys Gly Leu Asp Pro Glu Glu Ala Arg Gly Leu Gly Val Ala His Leu 
    210                 215                 220                 


Ala Arg Ala Ser Ser Asp Ile Val Ser Leu Ala Gly Pro Ser Ala Gly 
225                 230                 235                 240 


Pro Gly Ser Ser Glu Gly Gly Cys Ser Arg Arg Ser Ser Val Thr Val 
                245                 250                 255     


Glu Glu Arg Ala Arg Glu Arg Val Pro Tyr Gly Val Ser Val Val Glu 
            260                 265                 270         


Arg Asn Ala Arg Val Ile Lys Trp Leu Tyr Gly Leu Arg Gln Ala Arg 
        275                 280                 285             


Glu Ser Pro Ala Ala Glu Gly 
    290                 295 


<210>  3784
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM110B__Homo_sapiens__NP_671722

<400>  3784

Met Pro Thr Glu Thr Leu Gln Thr Gly Ser Met Val Lys Pro Val Ser 
1               5                   10                  15      


Pro Ala Gly Thr Phe Thr Ser Ala Val Pro Leu Arg Ile Leu Asn Lys 
            20                  25                  30          


Gly Pro Asp Tyr Phe Arg Arg Gln Ala Glu Pro Asn Pro Lys Arg Leu 
        35                  40                  45              


Ser Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Ser 
    50                  55                  60                  


Gln Glu Val Ile Asn Ala Lys Gln Glu Pro Val Lys Pro Ala Val Leu 
65                  70                  75                  80  


Ala Lys Pro Pro Val Cys Pro Ala Ala Lys Arg Ala Leu Gly Ser Pro 
                85                  90                  95      


Thr Leu Lys Val Phe Gly Asn His Ala Lys Thr Glu Ser Gly Val Gln 
            100                 105                 110         


Arg Glu Asn Leu Lys Leu Glu Ile Leu Lys Asn Ile Ile Asn Ser Ser 
        115                 120                 125             


Glu Gly Ser Ser Ser Gly Ser Gly His Lys His Ser Ser Arg Asn Trp 
    130                 135                 140                 


Pro Pro His Arg Ser Glu Ala Thr Asp Leu His Arg His Ser Phe Ala 
145                 150                 155                 160 


Glu Ser Leu Lys Val Tyr Pro Thr Gln Gly Arg Arg Ser Pro Gln Glu 
                165                 170                 175     


Gly Gly Ser His Val Gly Arg Arg Leu Leu Glu Gln Ser Ala Glu Ser 
            180                 185                 190         


Phe Leu His Val Ser His Ser Ser Ser Asp Ile Arg Lys Val Thr Ser 
        195                 200                 205             


Val Lys Pro Leu Lys Ala Ile Pro Cys Ser Ser Ser Ala Pro Pro Leu 
    210                 215                 220                 


Pro Pro Lys Pro Lys Ile Ala Ala Ile Ala Ser Met Lys Ser Pro Glu 
225                 230                 235                 240 


Ala Asp Pro Val Glu Pro Ala Cys Gly Val Ser Arg Arg Pro Ser Leu 
                245                 250                 255     


Gln Arg Ser Lys Ser Asp Leu Ser Asp Arg Tyr Phe Arg Val Asp Ala 
            260                 265                 270         


Asp Val Glu Arg Phe Phe Asn Tyr Cys Gly Leu Asp Pro Glu Glu Leu 
        275                 280                 285             


Glu Asn Leu Gly Met Glu Asn Phe Ala Arg Ala Asn Ser Asp Ile Ile 
    290                 295                 300                 


Ser Leu Asn Phe Arg Ser Ala Ser Met Ile Ser Ser Asp Cys Glu Gln 
305                 310                 315                 320 


Ser Gln Asp Ser Asn Ser Asp Leu Arg Asn Asp Asp Ser Ala Asn Asp 
                325                 330                 335     


Arg Val Pro Tyr Gly Ile Ser Ala Ile Glu Arg Asn Ala Arg Ile Ile 
            340                 345                 350         


Lys Trp Leu Tyr Ser Ile Lys Gln Ala Arg Glu Ser Gln Lys Val Ser 
        355                 360                 365             


His Val 
    370 


<210>  3785
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM110C__Homo_sapiens__NP_001071178

<400>  3785

Met Arg Ala Leu Ala Ala Leu Ser Ala Pro Pro Asn Glu Arg Leu Leu 
1               5                   10                  15      


Pro Arg Asp Pro Ala Ala Thr Arg Asp Pro Asp Ala Ala Arg Pro Ala 
            20                  25                  30          


Arg Arg Ser Ala Val Glu Arg Leu Ala Ala Asp Arg Ala Lys Tyr Val 
        35                  40                  45              


Arg Gly Arg Pro Gly Thr Gly Arg Gly Val Ala Ser Glu Gly Ser Gly 
    50                  55                  60                  


Pro Gly Ala Ile Lys Cys Pro Gly Asn Asp Pro Gly Pro Pro Ala Arg 
65                  70                  75                  80  


Ala Pro Ala Pro Val Ala Arg Arg Ala Ile Ala Arg Lys Pro Leu Arg 
                85                  90                  95      


Pro Asp Ser Leu Ile Ile Tyr Arg Gln Lys Cys Glu Phe Val Arg Gly 
            100                 105                 110         


Ser Gly Ala Asp Gly Pro Arg Ala Ser Leu Val Lys Lys Leu Phe Gln 
        115                 120                 125             


Gly Pro Gly Lys Asp Lys Ala Pro Val Pro Arg Thr Gly Asp Glu Gly 
    130                 135                 140                 


Lys Ala Gly Asn Pro Glu Thr Val Pro Thr Thr Pro Gly Pro Ala Ala 
145                 150                 155                 160 


Asp Pro Ala Ile Pro Glu Thr Pro Ala Pro Ala Ala Arg Ser Ala Ala 
                165                 170                 175     


Pro Ser Ser Val Pro Ala Ala Pro Pro Gly Pro Glu Pro Arg Val Val 
            180                 185                 190         


Arg Arg Arg Gly Leu Gln Arg Ser Gln Ser Asp Leu Ser Ser Arg Tyr 
        195                 200                 205             


Ser Ala Ala Leu Ala Glu Ser Asp Thr Phe Phe Gln Tyr Cys Gly Leu 
    210                 215                 220                 


Asp Pro Glu Val Val Glu Ala Leu Gly Arg Glu Asn Phe Thr Ala Gly 
225                 230                 235                 240 


Ser Asp Cys Val Thr Leu Lys Val Arg Ser Val Ser Val Ala Thr Ser 
                245                 250                 255     


Gly Ser Gly Phe Ser Arg His Ser Gly Gly Asp Asp Glu Gly Leu Gln 
            260                 265                 270         


Glu Glu Glu Leu Ile Glu Gln Val Pro Ser Thr Thr Ser Val Ile Glu 
        275                 280                 285             


Arg Asn Ala Arg Ile Ile Lys Trp Leu Tyr Thr Cys Lys Lys Ala Lys 
    290                 295                 300                 


Glu Thr Pro Ser Gln Glu Gln Ser Arg Thr Arg Gly Ser Lys Pro Ser 
305                 310                 315                 320 


Arg 
    


<210>  3786
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM111B__Homo_sapiens__NP_001136176

<400>  3786

Met Lys Gln Thr His Ala Asp Thr Pro Val Asp His Cys Leu Ser Gly 
1               5                   10                  15      


Ile Arg Lys Cys Ser Ser Thr Phe Lys Leu Lys Ser Glu Val Asn Lys 
            20                  25                  30          


His Glu Thr Ala Leu Glu Met Gln Asn Pro Asn Leu Asn Asn Lys Glu 
        35                  40                  45              


Cys Cys Phe Thr Phe Thr Leu Asn Gly Asn Ser Arg Lys Leu Asp Arg 
    50                  55                  60                  


Ser Val Phe Thr Ala Tyr Gly Lys Pro Ser Glu Ser Ile Tyr Ser Ala 
65                  70                  75                  80  


Leu Ser Ala Asn Asp Tyr Phe Ser Glu Arg Ile Lys Asn Gln Phe Asn 
                85                  90                  95      


Lys Asn Ile Ile Val Tyr Glu Glu Lys Thr Ile Asp Gly His Ile Asn 
            100                 105                 110         


Leu Gly Met Pro Leu Lys Cys Leu Pro Ser Asp Ser His Phe Lys Ile 
        115                 120                 125             


Thr Phe Gly Gln Arg Lys Ser Ser Lys Glu Asp Gly His Ile Leu Arg 
    130                 135                 140                 


Gln Cys Glu Asn Pro Asn Met Glu Cys Ile Leu Phe His Val Val Ala 
145                 150                 155                 160 


Ile Gly Arg Thr Arg Lys Lys Ile Val Lys Ile Asn Glu Leu His Glu 
                165                 170                 175     


Lys Gly Ser Lys Leu Cys Ile Tyr Ala Leu Lys Gly Glu Thr Ile Glu 
            180                 185                 190         


Gly Ala Leu Cys Lys Asp Gly Arg Phe Arg Ser Asp Ile Gly Glu Phe 
        195                 200                 205             


Glu Trp Lys Leu Lys Glu Gly His Lys Lys Ile Tyr Gly Lys Gln Ser 
    210                 215                 220                 


Met Val Asp Glu Val Ser Gly Lys Val Leu Glu Met Asp Ile Ser Lys 
225                 230                 235                 240 


Lys Lys Ala Leu Gln Gln Lys Asp Ile His Lys Lys Ile Lys Gln Asn 
                245                 250                 255     


Glu Ser Ala Thr Asp Glu Ile Asn His Gln Ser Leu Ile Gln Ser Lys 
            260                 265                 270         


Lys Lys Val His Lys Pro Lys Lys Asp Gly Glu Thr Lys Asp Val Glu 
        275                 280                 285             


His Ser Arg Glu Gln Ile Leu Pro Pro Gln Asp Leu Ser His Tyr Ile 
    290                 295                 300                 


Lys Asp Lys Thr Arg Gln Thr Ile Pro Arg Ile Arg Asn Tyr Tyr Phe 
305                 310                 315                 320 


Cys Ser Leu Pro Arg Lys Tyr Arg Gln Ile Asn Ser Gln Val Arg Arg 
                325                 330                 335     


Arg Pro His Leu Gly Arg Arg Tyr Ala Ile Asn Leu Asp Val Gln Lys 
            340                 345                 350         


Glu Ala Ile Asn Leu Leu Lys Asn Tyr Gln Thr Leu Asn Glu Ala Ile 
        355                 360                 365             


Met His Gln Tyr Pro Asn Phe Lys Glu Glu Ala Gln Trp Val Arg Lys 
    370                 375                 380                 


Tyr Phe Arg Glu Glu Gln Lys Arg Met Asn Leu Ser Pro Ala Lys Gln 
385                 390                 395                 400 


Phe Asn Ile Tyr Lys Lys Asp Phe Gly Lys Met Thr Ala Asn Ser Val 
                405                 410                 415     


Ser Val Ala Thr Cys Glu Gln Leu Thr Tyr Tyr Ser Lys Ser Val Gly 
            420                 425                 430         


Phe Met Gln Trp Asp Asn Asn Gly Asn Thr Gly Asn Ala Thr Cys Phe 
        435                 440                 445             


Val Phe Asn Gly Gly Tyr Ile Phe Thr Cys Arg His Val Val His Leu 
    450                 455                 460                 


Met Val Gly Lys Asn Thr His Pro Ser Leu Trp Pro Asp Ile Ile Ser 
465                 470                 475                 480 


Lys Cys Ala Lys Val Thr Phe Thr Tyr Thr Glu Phe Cys Pro Thr Pro 
                485                 490                 495     


Asp Asn Trp Phe Ser Ile Glu Pro Trp Leu Lys Val Ser Asn Glu Asn 
            500                 505                 510         


Leu Asp Tyr Ala Ile Leu Lys Leu Lys Glu Asn Gly Asn Ala Phe Pro 
        515                 520                 525             


Pro Gly Leu Trp Arg Gln Ile Ser Pro Gln Pro Ser Thr Gly Leu Ile 
    530                 535                 540                 


Tyr Leu Ile Gly His Pro Glu Gly Gln Ile Lys Lys Ile Asp Gly Cys 
545                 550                 555                 560 


Thr Val Ile Pro Leu Asn Glu Arg Leu Lys Lys Tyr Pro Asn Asp Cys 
                565                 570                 575     


Gln Asp Gly Leu Val Asp Leu Tyr Asp Thr Thr Ser Asn Val Tyr Cys 
            580                 585                 590         


Met Phe Thr Gln Arg Ser Phe Leu Ser Glu Val Trp Asn Thr His Thr 
        595                 600                 605             


Leu Ser Tyr Asp Thr Cys Phe Ser Asp Gly Ser Ser Gly Ser Pro Val 
    610                 615                 620                 


Phe Asn Ala Ser Gly Lys Leu Val Ala Leu His Thr Phe Gly Leu Phe 
625                 630                 635                 640 


Tyr Gln Arg Gly Phe Asn Val His Ala Leu Ile Glu Phe Gly Tyr Ser 
                645                 650                 655     


Met Asp Ser Ile Leu Cys Asp Ile Lys Lys Thr Asn Glu Ser Leu Tyr 
            660                 665                 670         


Lys Ser Leu Asn Asp Glu Lys Leu Glu Thr Tyr Asp Glu Glu Lys Gly 
        675                 680                 685             


Lys Gln Glu Ser Ser Leu Gln Asp His Gln Ile Glu Pro Met Glu Cys 
    690                 695                 700                 


<210>  3787
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM114A1__Homo_sapiens__NP_612398

<400>  3787

Met Ser Asp Asp Ala Gly Asp Thr Leu Ala Thr Gly Asp Lys Ala Glu 
1               5                   10                  15      


Val Thr Glu Met Pro Asn Ser Asp Ser Leu Pro Glu Asp Ala Glu Val 
            20                  25                  30          


His Cys Asp Ser Ala Ala Val Ser His Glu Pro Thr Pro Ala Asp Pro 
        35                  40                  45              


Arg Gly Glu Gly His Glu Asn Ala Ala Val Gln Gly Ala Gly Ala Ala 
    50                  55                  60                  


Ala Ile Gly Pro Pro Val Gln Pro Gln Asp Ala Asn Ala Leu Glu Pro 
65                  70                  75                  80  


Pro Leu Asn Gly Asp Val Thr Glu Asp Thr Leu Ala Glu Cys Ile Asp 
                85                  90                  95      


Ser Val Ser Leu Glu Ala Glu Pro Arg Ser Glu Ile Pro Leu Gln Glu 
            100                 105                 110         


Gln Asn Tyr Leu Ala Val Asp Ser Pro Pro Ser Gly Gly Gly Trp Ala 
        115                 120                 125             


Gly Trp Gly Ser Trp Gly Lys Ser Leu Leu Ser Ser Ala Ser Ala Thr 
    130                 135                 140                 


Val Gly His Gly Leu Thr Ala Val Lys Glu Lys Ala Gly Ala Thr Leu 
145                 150                 155                 160 


Arg Ile His Gly Val Asn Ser Gly Ser Ser Glu Gly Ala Gln Pro Asn 
                165                 170                 175     


Thr Glu Asn Gly Val Pro Glu Ile Thr Asp Ala Ala Thr Asp Gln Gly 
            180                 185                 190         


Pro Ala Glu Ser Pro Pro Thr Ser Pro Ser Ser Ala Ser Arg Gly Met 
        195                 200                 205             


Leu Ser Ala Ile Thr Asn Val Val Gln Asn Thr Gly Lys Ser Val Leu 
    210                 215                 220                 


Thr Gly Gly Leu Asp Ala Leu Glu Phe Ile Gly Lys Lys Thr Met Asn 
225                 230                 235                 240 


Val Leu Ala Glu Ser Asp Pro Gly Phe Lys Arg Thr Lys Thr Leu Met 
                245                 250                 255     


Glu Arg Thr Val Ser Leu Ser Gln Met Leu Arg Glu Ala Lys Glu Lys 
            260                 265                 270         


Glu Lys Gln Arg Leu Ala Gln Gln Leu Thr Met Glu Arg Thr Ala His 
        275                 280                 285             


Tyr Gly Met Leu Phe Asp Glu Tyr Gln Gly Leu Ser His Leu Glu Ala 
    290                 295                 300                 


Leu Glu Ile Leu Ser Asn Glu Ser Glu Ser Lys Val Gln Ser Phe Leu 
305                 310                 315                 320 


Ala Ser Leu Asp Gly Glu Lys Leu Glu Leu Leu Lys Asn Asp Leu Ile 
                325                 330                 335     


Ser Ile Lys Asp Ile Phe Ala Ala Lys Glu Leu Glu Asn Glu Glu Asn 
            340                 345                 350         


Gln Glu Glu Gln Gly Leu Glu Glu Lys Gly Glu Glu Phe Ala Arg Met 
        355                 360                 365             


Leu Thr Glu Leu Leu Phe Glu Leu His Val Ala Ala Thr Pro Asp Lys 
    370                 375                 380                 


Leu Asn Lys Ala Met Lys Arg Ala His Asp Trp Val Glu Glu Asp Gln 
385                 390                 395                 400 


Thr Val Val Ser Val Asp Val Ala Lys Val Ser Glu Glu Glu Thr Lys 
                405                 410                 415     


Lys Glu Glu Lys Glu Glu Lys Ser Gln Asp Pro Gln Glu Asp Lys Lys 
            420                 425                 430         


Glu Glu Lys Lys Thr Lys Thr Ile Glu Glu Val Tyr Met Ser Ser Ile 
        435                 440                 445             


Glu Ser Leu Ala Glu Val Thr Ala Arg Cys Ile Glu Gln Leu His Lys 
    450                 455                 460                 


Val Ala Glu Leu Ile Leu His Gly Gln Glu Glu Glu Lys Pro Ala Gln 
465                 470                 475                 480 


Asp Gln Ala Lys Val Leu Ile Lys Leu Thr Thr Ala Met Cys Asn Glu 
                485                 490                 495     


Val Ala Ser Leu Ser Lys Lys Phe Thr Asn Ser Leu Thr Thr Val Gly 
            500                 505                 510         


Ser Asn Lys Lys Ala Glu Val Leu Asn Pro Met Ile Ser Ser Val Leu 
        515                 520                 525             


Leu Glu Gly Cys Asn Ser Thr Thr Tyr Ile Gln Asp Ala Phe Gln Leu 
    530                 535                 540                 


Leu Leu Pro Val Leu Gln Val Ser His Ile Gln Thr Ser Cys Leu Lys 
545                 550                 555                 560 


Ala Gln Pro 
            


<210>  3788
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM120B__Homo_sapiens__NP_001273308

<400>  3788

Met Asp Arg Gln Met Ile Leu Ser Arg Ser Ser Val Met Gly Val Arg 
1               5                   10                  15      


Gly Leu Gln Gly Phe Val Gly Ser Thr Cys Pro His Ile Cys Thr Val 
            20                  25                  30          


Val Asn Phe Lys Glu Leu Ala Glu His His Arg Ser Lys Tyr Pro Gly 
        35                  40                  45              


Cys Thr Pro Thr Ile Val Val Asp Ala Met Cys Cys Leu Arg Tyr Trp 
    50                  55                  60                  


Tyr Thr Pro Glu Ser Trp Ile Cys Gly Gly Gln Trp Arg Glu Tyr Phe 
65                  70                  75                  80  


Ser Ala Leu Arg Asp Phe Val Lys Thr Phe Thr Ala Ala Gly Ile Lys 
                85                  90                  95      


Leu Ile Phe Phe Phe Asp Gly Met Val Glu Gln Asp Lys Arg Asp Glu 
            100                 105                 110         


Trp Val Lys Arg Arg Leu Lys Asn Asn Arg Glu Ile Ser Arg Ile Phe 
        115                 120                 125             


His Tyr Ile Lys Ser His Lys Glu Gln Pro Gly Arg Asn Met Phe Phe 
    130                 135                 140                 


Ile Pro Ser Gly Leu Ala Val Phe Thr Arg Phe Ala Leu Lys Thr Leu 
145                 150                 155                 160 


Gly Gln Glu Thr Leu Cys Ser Leu Gln Glu Ala Asp Tyr Glu Val Ala 
                165                 170                 175     


Ser Tyr Gly Leu Gln His Asn Cys Leu Gly Ile Leu Gly Glu Asp Thr 
            180                 185                 190         


Asp Tyr Leu Ile Tyr Asp Thr Cys Pro Tyr Phe Ser Ile Ser Glu Leu 
        195                 200                 205             


Cys Leu Glu Ser Leu Asp Thr Val Met Leu Cys Arg Glu Lys Leu Cys 
    210                 215                 220                 


Glu Ser Leu Gly Leu Cys Val Ala Asp Leu Pro Leu Leu Ala Cys Leu 
225                 230                 235                 240 


Leu Gly Asn Asp Ile Ile Pro Glu Gly Met Phe Glu Ser Phe Arg Tyr 
                245                 250                 255     


Lys Cys Leu Ser Ser Tyr Thr Ser Val Lys Glu Asn Phe Asp Lys Lys 
            260                 265                 270         


Gly Asn Ile Ile Leu Ala Val Ser Asp His Ile Ser Lys Val Leu Tyr 
        275                 280                 285             


Leu Tyr Gln Gly Glu Lys Lys Leu Glu Glu Ile Leu Pro Leu Gly Pro 
    290                 295                 300                 


Asn Lys Ala Leu Phe Tyr Lys Gly Met Ala Ser Tyr Leu Leu Pro Gly 
305                 310                 315                 320 


Gln Lys Ser Pro Trp Phe Phe Gln Lys Pro Lys Gly Val Ile Thr Leu 
                325                 330                 335     


Asp Lys Gln Val Ile Ser Thr Ser Ser Asp Ala Glu Ser Arg Glu Glu 
            340                 345                 350         


Val Pro Met Cys Ser Asp Ala Glu Ser Arg Gln Glu Val Pro Met Cys 
        355                 360                 365             


Thr Gly Pro Glu Ser Arg Arg Glu Val Pro Val Tyr Thr Asp Ser Glu 
    370                 375                 380                 


Pro Arg Gln Glu Val Pro Met Cys Ser Asp Pro Glu Pro Arg Gln Glu 
385                 390                 395                 400 


Val Pro Thr Cys Thr Gly Pro Glu Ser Arg Arg Glu Val Pro Met Cys 
                405                 410                 415     


Ser Asp Pro Glu Pro Arg Gln Glu Val Pro Met Cys Thr Gly Pro Glu 
            420                 425                 430         


Ala Arg Gln Glu Val Pro Met Tyr Thr Asp Ser Glu Pro Arg Gln Glu 
        435                 440                 445             


Val Pro Met Tyr Thr Asp Ser Glu Pro Arg Gln Glu Val Pro Met Tyr 
    450                 455                 460                 


Thr Gly Ser Glu Pro Arg Gln Glu Val Pro Met Tyr Thr Gly Pro Glu 
465                 470                 475                 480 


Ser Arg Gln Glu Val Pro Met Tyr Thr Gly Pro Glu Ser Arg Gln Glu 
                485                 490                 495     


Val Leu Ile Arg Thr Asp Pro Glu Ser Arg Gln Glu Ile Met Cys Thr 
            500                 505                 510         


Gly His Glu Ser Lys Gln Glu Val Pro Ile Cys Thr Asp Pro Ile Ser 
        515                 520                 525             


Lys Gln Glu Asp Ser Met Cys Thr His Ala Glu Ile Asn Gln Lys Leu 
    530                 535                 540                 


Pro Val Ala Thr Asp Phe Glu Phe Lys Leu Glu Ala Leu Met Cys Thr 
545                 550                 555                 560 


Asn Pro Glu Ile Lys Gln Glu Asp Pro Thr Asn Val Gly Pro Glu Val 
                565                 570                 575     


Lys Gln Gln Val Thr Met Val Ser Asp Thr Glu Ile Leu Lys Val Ala 
            580                 585                 590         


Arg Thr His His Val Gln Ala Glu Ser Tyr Leu Val Tyr Asn Ile Met 
        595                 600                 605             


Ser Ser Gly Glu Ile Glu Cys Ser Asn Thr Leu Glu Asp Glu Leu Asp 
    610                 615                 620                 


Gln Ala Leu Pro Ser Gln Ala Phe Ile Tyr Arg Pro Ile Arg Gln Arg 
625                 630                 635                 640 


Val Tyr Ser Leu Leu Leu Glu Asp Cys Gln Asp Val Thr Ser Thr Cys 
                645                 650                 655     


Leu Ala Val Lys Glu Trp Phe Val Tyr Pro Gly Asn Pro Leu Arg His 
            660                 665                 670         


Pro Asp Leu Val Arg Pro Leu Gln Met Thr Ile Pro Gly Gly Thr Pro 
        675                 680                 685             


Ser Leu Lys Ile Leu Trp Leu Asn Gln Glu Pro Glu Ile Gln Val Arg 
    690                 695                 700                 


Arg Leu Asp Thr Leu Leu Ala Cys Phe Asn Leu Ser Ser Ser Arg Glu 
705                 710                 715                 720 


Glu Leu Gln Ala Val Glu Ser Pro Phe Gln Ala Leu Cys Cys Leu Leu 
                725                 730                 735     


Ile Tyr Leu Phe Val Gln Val Asp Thr Leu Cys Leu Glu Asp Leu His 
            740                 745                 750         


Ala Phe Ile Ala Gln Ala Leu Cys Leu Gln Gly Lys Ser Thr Ser Gln 
        755                 760                 765             


Leu Val Asn Leu Gln Pro Asp Tyr Ile Asn Pro Arg Ala Val Gln Leu 
    770                 775                 780                 


Gly Ser Leu Leu Val Arg Gly Leu Thr Thr Leu Val Leu Val Asn Ser 
785                 790                 795                 800 


Ala Cys Gly Phe Pro Trp Lys Thr Ser Asp Phe Met Pro Trp Asn Val 
                805                 810                 815     


Phe Asp Gly Lys Leu Phe His Gln Lys Tyr Leu Gln Ser Glu Lys Gly 
            820                 825                 830         


Tyr Ala Val Glu Val Leu Leu Glu Gln Asn Arg Ser Arg Leu Thr Lys 
        835                 840                 845             


Phe His Asn Leu Lys Ala Val Val Cys Lys Ala Cys Met Lys Glu Asn 
    850                 855                 860                 


Arg Arg Ile Thr Gly Arg Ala His Trp Gly Ser His His Ala Gly Arg 
865                 870                 875                 880 


Trp Gly Arg Gln Gly Ser Ser Tyr His Arg Thr Gly Ser Gly Tyr Ser 
                885                 890                 895     


Arg Ser Ser Gln Gly Gln Pro Trp Arg Asp Gln Gly Pro Gly Ser Arg 
            900                 905                 910         


Gln Tyr Glu His Asp Gln Trp Arg Arg Tyr 
        915                 920         


<210>  3789
<211>  1096
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM120C__Homo_sapiens__NP_060318

<400>  3789

Met Gly Val Gln Gly Phe Gln Glu Phe Leu Glu Lys Arg Cys Pro Gly 
1               5                   10                  15      


Ala Val Val Pro Val Asp Leu Leu Lys Leu Ala Arg Thr Val Ser Arg 
            20                  25                  30          


Gln Gln Gln Gln Gln His Leu His Arg Gln Leu Pro Pro Thr Ala Ala 
        35                  40                  45              


Leu Ala Pro Gly Ala Pro Arg Ala Ala Arg Gly Ser Val Pro Leu Gln 
    50                  55                  60                  


Pro Pro Leu Pro Pro Ala Ala Leu Gly Ala Tyr Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Pro Thr Arg His His His Pro Ala His His Phe His His His Gly Gln 
                85                  90                  95      


Ala Gln Pro Gly Leu His Pro Pro Leu Pro Pro Pro Pro Pro Pro Gln 
            100                 105                 110         


Leu Pro Gly Ala Arg Val Leu Val Asp Ala Gly Ser Ala Leu Pro Arg 
        115                 120                 125             


Leu Tyr Gly Gly Tyr Gln Thr Asp Trp Val Cys Gly Gly Gln Trp Asn 
    130                 135                 140                 


Ala Met Leu Gly Tyr Leu Ser Ala Leu Cys Gln Ala Cys Ala Tyr Pro 
145                 150                 155                 160 


Gly Gly Asp Gly Leu Glu Leu Val Val Met Phe Pro Gly Gly Leu Gly 
                165                 170                 175     


Lys Asp Arg Leu Ala Glu Trp Gly Arg Arg Cys Gln Ala Glu Arg Gln 
            180                 185                 190         


Thr Ala Gln Leu Ile Val Gly His Val Gly Asn Lys Gly Thr Pro Pro 
        195                 200                 205             


Pro Arg Ala Trp Phe Leu Pro Pro Ala Cys Leu Ser His Cys Val Arg 
    210                 215                 220                 


Leu Ala Leu Ile Arg Phe Arg Val Lys Val Phe Gln Ser Leu Glu Asp 
225                 230                 235                 240 


His His Leu Glu Val Val Ala Phe Phe Arg Glu Asn Gly Phe His Gly 
                245                 250                 255     


Leu Leu Ala His Asp Ser Glu Tyr Ala Leu Tyr Asn Ile Pro Ser Tyr 
            260                 265                 270         


Tyr Ser Ser His Ala Leu Lys Leu Ser Trp Asn Gly Lys Asn Leu Thr 
        275                 280                 285             


Thr Asn Gln Phe Leu Met Gln Glu Val Ala Lys Gln Leu Gly Leu Lys 
    290                 295                 300                 


Arg Met Asn Phe Pro Ile Phe Ala Ala Leu Leu Gly Asn His Ile Leu 
305                 310                 315                 320 


Pro Asp Glu Asp Leu Ala Ala Phe His Trp Ser Leu Leu Gly Pro Glu 
                325                 330                 335     


His Pro Leu Ala Ser Leu Lys Val Arg Ala His Gln Leu Val Leu Pro 
            340                 345                 350         


Pro Cys Asp Val Val Ile Lys Ala Val Ser Glu Tyr Val Ser Ser Ile 
        355                 360                 365             


Lys Asp Pro Ser Asn Leu Asp Val Val Gly Lys Asp Val Phe Lys Gln 
    370                 375                 380                 


Ser Gln Ser Arg Thr Glu Asp Lys Ile Glu Arg Phe Lys Lys Ala Val 
385                 390                 395                 400 


Glu Tyr Tyr Ser Val Thr Thr Lys Leu Ser Ser Leu Pro Val Gly Pro 
                405                 410                 415     


Ser Phe Leu Gly Phe Arg Asn Asn Arg Leu Gly Asn Pro Pro Leu Pro 
            420                 425                 430         


Arg Asn Gln Val Gly Thr Ile Ser Ala Gly Lys Pro Met Phe Ser His 
        435                 440                 445             


Gln Val Pro Gln Lys Val Lys Tyr Pro Pro Pro Phe Pro Val Gly Pro 
    450                 455                 460                 


Asn Ser Ser Leu Leu Phe Ser Ser His Ala Leu Gly Glu Ser His Ala 
465                 470                 475                 480 


Phe Ser Glu Asp Pro Met Leu Gln Asn Ser Pro Phe Ala Asn Trp Ala 
                485                 490                 495     


Val Ser Tyr Asp Ser Ser Ala Ser Gln Phe Pro Asn Tyr Leu Pro Ser 
            500                 505                 510         


Lys Ala Ser Pro Pro Leu Gly Pro Asp Ser Ser His Ser Ser Ser Ser 
        515                 520                 525             


Asp Gly Asp Glu Pro Asn Gly Ala Ser Ser Asp His Ile Thr Glu Ala 
    530                 535                 540                 


Phe His His Gln Pro Glu Trp Gly Asn Pro Asn Arg Asp Arg Gly Ser 
545                 550                 555                 560 


Trp Ala Gln Pro Val Asp Thr Gly Val Ser Glu Ala Ser Leu Gly Asp 
                565                 570                 575     


Gly Glu Pro His Ile Pro Ser Leu Leu Ser Met Ser Thr Arg Asn His 
            580                 585                 590         


Met Asp Ile Thr Ile Pro Pro Leu Pro Pro Val Ala Pro Glu Val Leu 
        595                 600                 605             


Arg Val Ala Glu His Arg His Arg Arg Gly Leu Met Tyr Pro Tyr Ile 
    610                 615                 620                 


Tyr His Val Leu Thr Lys Gly Glu Ile Lys Ile Pro Val Cys Ile Glu 
625                 630                 635                 640 


Asp Glu Cys Asn Met Glu Leu Pro Pro Ala Ala Leu Leu Phe Arg Ser 
                645                 650                 655     


Ala Arg Gln Tyr Val Tyr Gly Val Leu Phe Ser Leu Ala Glu Thr Gln 
            660                 665                 670         


Arg Lys Met Glu Arg Leu Ala Met Arg Arg Arg Leu Pro Val Glu Val 
        675                 680                 685             


Pro Ser Val Ile Leu Lys Glu Trp Ser Ala Tyr Lys Gly Lys Ser Pro 
    690                 695                 700                 


Gln Thr Pro Glu Leu Val Ser Ala Leu Thr Phe Arg Glu Trp Thr Cys 
705                 710                 715                 720 


Pro Asn Leu Lys Lys Leu Trp Leu Gly Lys Ala Val Glu Asp Lys Asn 
                725                 730                 735     


Arg Arg Met Arg Ala Phe Leu Ala Cys Met Lys Ser Asp Thr Pro Ser 
            740                 745                 750         


Met Leu Asn Pro Ala Asn Val Pro Thr His Leu Leu Leu Met Cys Cys 
        755                 760                 765             


Val Leu Arg Tyr Met Val Gln Trp Pro Gly Gly Arg Ile Leu His Arg 
    770                 775                 780                 


His Glu Leu Asp Thr Phe Leu Ala Gln Ala Val Ser Thr Gln Leu Tyr 
785                 790                 795                 800 


Glu Pro Asp Arg Leu Gln Glu Leu Lys Ile Glu Lys Leu Asp Ala Arg 
                805                 810                 815     


Gly Ile Gln Leu Ala Ala Leu Phe Met Ser Gly Val Asp Thr Ala Leu 
            820                 825                 830         


Phe Ala Asn Asp Ala Cys Gly Gln Pro Val Pro Trp Glu His Cys Cys 
        835                 840                 845             


Pro Trp Ile Tyr Phe Asp Gly Lys Leu Phe Gln Ser Lys Leu Ile Lys 
    850                 855                 860                 


Ala Gly Arg Glu Arg Val Ser Leu Val Glu Leu Cys Asp Gly Gln Ala 
865                 870                 875                 880 


Asp Leu Ala Thr Lys Val Glu Lys Met Arg Gln Ser Ile Leu Glu Gly 
                885                 890                 895     


Val Asn Met Asn His Pro Pro Pro Ser Ala Leu Leu Pro Ser Pro Thr 
            900                 905                 910         


Phe Val Pro Pro Met Val Pro Ser Leu Tyr Pro Val Ser Leu Tyr Ser 
        915                 920                 925             


Arg Ala Met Gly Ser Met Pro Leu Pro Pro Gln Gly Arg Ser Arg Gly 
    930                 935                 940                 


Phe Ala Gly Leu His Pro Ile Pro Pro Gln Gly Gly Lys Leu Glu Ile 
945                 950                 955                 960 


Ala Gly Met Val Val Gly Gln Trp Ala Gly Ser Arg Ser Ser Arg Gly 
                965                 970                 975     


Arg Gly Ser Phe Gly Met Gln Val Val Ser Val Gly Gly Pro Gly Lys 
            980                 985                 990         


Gly His Gly Lys Glu Gln Thr Gly  Arg Gly Ser Lys Gly  His Lys Lys 
        995                 1000                 1005             


Gly Asn  Lys Gln Gly Ser Ser  Asp Gly Val Ser Lys  Ser Leu Glu 
    1010                 1015                 1020             


Leu His  Gln Gly Arg Ser Arg  Ser Gln Val Asn Gly  Asn Ser Gly 
    1025                 1030                 1035             


Ala Leu  Ile Lys Glu Glu Lys  Ser Asp His Arg Leu  Pro Ala Pro 
    1040                 1045                 1050             


Ser Gln  Cys Ala Leu Ser Arg  Asp Ser Asn Glu Cys  Asn Asn Gly 
    1055                 1060                 1065             


Asn Arg  Tyr Leu Pro Met Asn  Asn Arg Glu Lys Asn  His Leu Gln 
    1070                 1075                 1080             


Glu Gln  Lys Leu Glu Thr Val  Ala Gln Arg Lys Glu  Asp 
    1085                 1090                 1095     


<210>  3790
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM124B__Homo_sapiens__NP_001116251

<400>  3790

Met Asp Glu Thr Gln Gly Pro Leu Ala Met Thr Val His Leu Leu Ala 
1               5                   10                  15      


Asn Ser Gly His Gly Ser Leu Leu Gln Arg Thr Leu Asp Gln Leu Leu 
            20                  25                  30          


Asp Cys Ile Cys Pro Glu Val Arg Leu Phe Gln Val Ser Glu Arg Ala 
        35                  40                  45              


Ser Pro Val Lys Tyr Cys Glu Lys Ser His Ser Lys Arg Ser Arg Phe 
    50                  55                  60                  


Pro Gly Met Ser Val Leu Leu Phe Leu His Glu Ser Pro Gly Glu Asp 
65                  70                  75                  80  


Arg Leu Phe Arg Val Leu Asp Ser Leu Gln His Ser Pro Trp Gln Cys 
                85                  90                  95      


Tyr Pro Thr Gln Asp Thr Arg Gly Arg Leu Cys Pro Tyr Phe Phe Ala 
            100                 105                 110         


Asn Gln Glu Phe Tyr Ser Leu Asp Ser Gln Leu Pro Ile Trp Gly Val 
        115                 120                 125             


Arg Gln Val His Cys Gly Ser Glu Ile Leu Arg Val Thr Leu Tyr Cys 
    130                 135                 140                 


Ser Phe Asp Asn Tyr Glu Asp Ala Ile Arg Leu Tyr Glu Met Ile Leu 
145                 150                 155                 160 


Gln Arg Glu Ala Thr Leu Gln Lys Ser Asn Phe Cys Phe Phe Val Leu 
                165                 170                 175     


Tyr Ala Ser Lys Ser Phe Ala Leu Gln Leu Ser Leu Lys Gln Leu Pro 
            180                 185                 190         


Pro Gly Met Ser Val Asp Pro Lys Glu Ser Ser Val Leu Gln Phe Lys 
        195                 200                 205             


Val Gln Glu Ile Gly Gln Leu Val Pro Leu Leu Pro Asn Pro Cys Met 
    210                 215                 220                 


Pro Ile Ser Ser Thr Arg Trp Gln Thr Gln Asp Tyr Asp Gly Asn Lys 
225                 230                 235                 240 


Ile Leu Leu Gln Val Gln Leu Asn Pro Glu Leu Gly Val Lys Asn Gly 
                245                 250                 255     


Ile Leu Gly Ala Gly Met Leu Pro Leu Gly Ser Arg Leu Thr Ser Val 
            260                 265                 270         


Ser Ala Lys Arg Thr Ser Glu Pro Arg Ser Gln Arg Asn Gln Gly Lys 
        275                 280                 285             


Arg Ser Gln Gly His Ser Leu Glu Leu Pro Glu Pro Ser Gly Ser Pro 
    290                 295                 300                 


Thr Ser Asp Arg Cys Ala Gly Thr Ser Trp Lys Ser Pro Gly Arg Ser 
305                 310                 315                 320 


Phe Gln Val Ser Ser Pro Ala Met Gly Ala His Leu His Leu Ser Ser 
                325                 330                 335     


His His Leu Glu Ser Gly Ala Arg Met Lys Val Leu Asn Arg Glu Asn 
            340                 345                 350         


Ser Phe Gln Lys Leu Glu Ala Glu Thr Asn Val Asp Thr Gly Leu Thr 
        355                 360                 365             


Ile Ile Asn Ser Glu Pro Arg Gln Thr Tyr Phe Gly Gly Phe Pro Arg 
    370                 375                 380                 


Asp Leu Gln Thr Ser Gln Pro Pro Phe Cys Leu Pro Ala Ser Ser Leu 
385                 390                 395                 400 


Gly Val Ala Thr Ser Lys Asn Asn Ser Val Leu Lys Glu Arg Val Ser 
                405                 410                 415     


Pro Leu Pro Leu Ala Gly Gln Arg Asp Leu Gly Thr Arg Lys Thr Ile 
            420                 425                 430         


Ser Glu Cys Leu Leu His Leu Gln Val Gln Gly Glu Glu Lys Glu Glu 
        435                 440                 445             


Asp Glu Glu Glu Phe Phe Ile 
    450                 455 


<210>  3791
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM126A__Homo_sapiens__NP_115970

<400>  3791

Met Phe Thr Ser Glu Lys Gly Val Val Glu Glu Trp Leu Ser Glu Phe 
1               5                   10                  15      


Lys Thr Leu Pro Glu Thr Ser Leu Pro Asn Tyr Ala Thr Asn Leu Lys 
            20                  25                  30          


Asp Lys Ser Ser Leu Val Ser Ser Leu Tyr Lys Val Ile Gln Glu Pro 
        35                  40                  45              


Gln Ser Glu Leu Leu Glu Pro Val Cys His Gln Leu Phe Glu Phe Tyr 
    50                  55                  60                  


Arg Ser Gly Glu Glu Gln Leu Leu Gln Phe Thr Leu Gln Phe Leu Pro 
65                  70                  75                  80  


Glu Leu Ile Trp Cys Tyr Leu Ala Val Ser Ala Ser Arg Asn Val His 
                85                  90                  95      


Ser Ser Gly Cys Ile Glu Ala Leu Leu Leu Gly Val Tyr Asn Leu Glu 
            100                 105                 110         


Ile Val Asp Lys Gln Gly His Thr Lys Val Leu Ser Phe Thr Ile Pro 
        115                 120                 125             


Ser Leu Ser Lys Pro Ser Val Tyr His Glu Pro Ser Ser Ile Gly Ser 
    130                 135                 140                 


Met Ala Leu Thr Glu Ser Ala Leu Ser Gln His Gly Leu Ser Lys Val 
145                 150                 155                 160 


Val Tyr Ser Gly Pro His Pro Gln Arg Glu Met Leu Thr Ala Gln Asn 
                165                 170                 175     


Arg Phe Glu Val Leu Thr Phe Leu Leu Leu Cys Tyr Asn Ala Ala Leu 
            180                 185                 190         


Thr Tyr Met Pro Ser Val Ser Leu Gln Ser Leu Cys Gln Ile Cys Ser 
        195                 200                 205             


Arg Ile Cys Val Cys Gly Tyr Pro Arg Gln His Val Arg Lys Tyr Lys 
    210                 215                 220                 


Gly Ile Ser Ser Arg Ile Pro Val Ser Ser Gly Phe Met Val Gln Met 
225                 230                 235                 240 


Leu Thr Gly Ile Tyr Phe Ala Phe Tyr Asn Gly Glu Trp Asp Leu Ala 
                245                 250                 255     


Gln Lys Ala Leu Asp Asp Ile Ile Tyr Arg Ala Gln Leu Glu Leu Tyr 
            260                 265                 270         


Pro Glu Pro Leu Leu Val Ala Asn Ala Ile Lys Ala Ser Leu Pro His 
        275                 280                 285             


Gly Pro Met Lys Ser Asn Lys Glu Gly Thr Arg Cys Ile Gln Val Glu 
    290                 295                 300                 


Ile Thr Pro Thr Ser Ser Arg Ile Ser Arg Asn Ala Val Thr Ser Met 
305                 310                 315                 320 


Ser Ile Arg Gly His Arg Trp Lys Arg His Gly Asn Thr Glu Leu Thr 
                325                 330                 335     


Gly Gln Glu Glu Leu Met Glu Ile Ser Glu Val Asp Glu Gly Phe Tyr 
            340                 345                 350         


Ser Arg Ala Ala Ser Ser Thr Ser Gln Ser Gly Leu Ser Asn Ser Ser 
        355                 360                 365             


His Asn Cys Ser Asn Lys Pro Ser Ile Gly Lys Asn His Arg Arg Ser 
    370                 375                 380                 


Gly Gly Ser Lys Thr Gly Gly Lys Glu Lys Glu Thr Thr Gly Glu Ser 
385                 390                 395                 400 


Cys Lys Asp His Phe Ala Arg Lys Gln Thr Gln Arg Ala Gln Ser Glu 
                405                 410                 415     


Asn Leu Glu Leu Leu Ser Leu Lys Arg Leu Thr Leu Thr Thr Ser Gln 
            420                 425                 430         


Ser Leu Pro Lys Pro Ser Ser His Gly Leu Ala Lys Thr Ala Ala Thr 
        435                 440                 445             


Val Phe Ser Lys Ser Phe Glu Gln Val Ser Gly Val Thr Val Pro His 
    450                 455                 460                 


Asn Pro Ser Ser Ala Val Gly Cys Gly Ala Gly Thr Asp Ala Asn Arg 
465                 470                 475                 480 


Phe Ser Ala Cys Ser Leu Gln Glu Glu Lys Leu Ile Tyr Val Ser Glu 
                485                 490                 495     


Arg Thr Glu Leu Pro Met Lys His Gln Ser Gly Gln Gln Arg Pro Pro 
            500                 505                 510         


Ser Ile Ser Ile Thr Leu Ser Thr Asp 
        515                 520     


<210>  3792
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM129A__Homo_sapiens__NP_443198

<400>  3792

Met Gly Gly Ser Ala Ser Ser Gln Leu Asp Glu Gly Lys Cys Ala Tyr 
1               5                   10                  15      


Ile Arg Gly Lys Thr Glu Ala Ala Ile Lys Asn Phe Ser Pro Tyr Tyr 
            20                  25                  30          


Ser Arg Gln Tyr Ser Val Ala Phe Cys Asn His Val Arg Thr Glu Val 
        35                  40                  45              


Glu Gln Gln Arg Asp Leu Thr Ser Gln Phe Leu Lys Thr Lys Pro Pro 
    50                  55                  60                  


Leu Ala Pro Gly Thr Ile Leu Tyr Glu Ala Glu Leu Ser Gln Phe Ser 
65                  70                  75                  80  


Glu Asp Ile Lys Lys Trp Lys Glu Arg Tyr Val Val Val Lys Asn Asp 
                85                  90                  95      


Tyr Ala Val Glu Ser Tyr Glu Asn Lys Glu Ala Tyr Gln Arg Gly Ala 
            100                 105                 110         


Ala Pro Lys Cys Arg Ile Leu Pro Ala Gly Gly Lys Val Leu Thr Ser 
        115                 120                 125             


Glu Asp Glu Tyr Asn Leu Leu Ser Asp Arg His Phe Pro Asp Pro Leu 
    130                 135                 140                 


Ala Ser Ser Glu Lys Glu Asn Thr Gln Pro Phe Val Val Leu Pro Lys 
145                 150                 155                 160 


Glu Phe Pro Val Tyr Leu Trp Gln Pro Phe Phe Arg His Gly Tyr Phe 
                165                 170                 175     


Cys Phe His Glu Ala Ala Asp Gln Lys Arg Phe Ser Ala Leu Leu Ser 
            180                 185                 190         


Asp Cys Val Arg His Leu Asn His Asp Tyr Met Lys Gln Met Thr Phe 
        195                 200                 205             


Glu Ala Gln Ala Phe Leu Glu Ala Val Gln Phe Phe Arg Gln Glu Lys 
    210                 215                 220                 


Gly His Tyr Gly Ser Trp Glu Met Ile Thr Gly Asp Glu Ile Gln Ile 
225                 230                 235                 240 


Leu Ser Asn Leu Val Met Glu Glu Leu Leu Pro Thr Leu Gln Thr Asp 
                245                 250                 255     


Leu Leu Pro Lys Met Lys Gly Lys Lys Asn Asp Arg Lys Arg Thr Trp 
            260                 265                 270         


Leu Gly Leu Leu Glu Glu Ala Tyr Thr Leu Val Gln His Gln Val Ser 
        275                 280                 285             


Glu Gly Leu Ser Ala Leu Lys Glu Glu Cys Arg Ala Leu Thr Lys Gly 
    290                 295                 300                 


Leu Glu Gly Thr Ile Arg Ser Asp Met Asp Gln Ile Val Asn Ser Lys 
305                 310                 315                 320 


Asn Tyr Leu Ile Gly Lys Ile Lys Ala Met Val Ala Gln Pro Ala Glu 
                325                 330                 335     


Lys Ser Cys Leu Glu Ser Val Gln Pro Phe Leu Ala Ser Ile Leu Glu 
            340                 345                 350         


Glu Leu Met Gly Pro Val Ser Ser Gly Phe Ser Glu Val Arg Val Leu 
        355                 360                 365             


Phe Glu Lys Glu Val Asn Glu Val Ser Gln Asn Phe Gln Thr Thr Lys 
    370                 375                 380                 


Asp Ser Val Gln Leu Lys Glu His Leu Asp Arg Leu Met Asn Leu Pro 
385                 390                 395                 400 


Leu His Ser Val Lys Met Glu Pro Cys Tyr Thr Lys Val Asn Leu Leu 
                405                 410                 415     


His Glu Arg Leu Gln Asp Leu Lys Ser Arg Phe Arg Phe Pro His Ile 
            420                 425                 430         


Asp Leu Val Val Gln Arg Thr Gln Asn Tyr Met Gln Glu Leu Met Glu 
        435                 440                 445             


Asn Ala Val Phe Thr Phe Glu Gln Leu Leu Ser Pro His Leu Gln Gly 
    450                 455                 460                 


Glu Ala Ser Lys Thr Ala Val Ala Ile Glu Lys Val Lys Leu Arg Val 
465                 470                 475                 480 


Leu Lys Gln Tyr Asp Tyr Asp Ser Ser Thr Ile Arg Lys Lys Ile Phe 
                485                 490                 495     


Gln Glu Ala Leu Val Gln Ile Thr Leu Pro Thr Val Gln Lys Ala Leu 
            500                 505                 510         


Ala Ser Thr Cys Lys Pro Glu Leu Gln Lys Tyr Glu Gln Phe Ile Phe 
        515                 520                 525             


Ala Asp His Thr Asn Met Ile His Val Glu Asn Val Tyr Glu Glu Ile 
    530                 535                 540                 


Leu His Gln Ile Leu Leu Asp Glu Thr Leu Lys Val Ile Lys Glu Ala 
545                 550                 555                 560 


Ala Ile Leu Lys Lys His Asn Leu Phe Glu Asp Asn Met Ala Leu Pro 
                565                 570                 575     


Ser Glu Ser Val Ser Ser Leu Thr Asp Leu Lys Pro Pro Thr Gly Ser 
            580                 585                 590         


Asn Gln Ala Ser Pro Ala Arg Arg Ala Ser Ala Ile Leu Pro Gly Val 
        595                 600                 605             


Leu Gly Ser Glu Thr Leu Ser Asn Glu Val Phe Gln Glu Ser Glu Glu 
    610                 615                 620                 


Glu Lys Gln Pro Glu Val Pro Ser Ser Leu Ala Lys Gly Glu Ser Leu 
625                 630                 635                 640 


Ser Leu Pro Gly Pro Ser Pro Pro Pro Asp Gly Thr Glu Gln Val Ile 
                645                 650                 655     


Ile Ser Arg Val Asp Asp Pro Val Val Asn Pro Val Ala Thr Glu Asp 
            660                 665                 670         


Thr Ala Gly Leu Pro Gly Thr Cys Ser Ser Glu Leu Glu Phe Gly Gly 
        675                 680                 685             


Thr Leu Glu Asp Glu Glu Pro Ala Gln Glu Glu Pro Glu Pro Ile Thr 
    690                 695                 700                 


Ala Ser Gly Ser Leu Lys Ala Leu Arg Lys Leu Leu Thr Ala Ser Val 
705                 710                 715                 720 


Glu Val Pro Val Asp Ser Ala Pro Val Met Glu Glu Asp Thr Asn Gly 
                725                 730                 735     


Glu Ser His Val Pro Gln Glu Asn Glu Glu Glu Glu Glu Lys Glu Pro 
            740                 745                 750         


Ser Gln Ala Ala Ala Ile His Pro Asp Asn Cys Glu Glu Ser Glu Val 
        755                 760                 765             


Ser Glu Arg Glu Ala Gln Pro Pro Cys Pro Glu Ala His Gly Glu Glu 
    770                 775                 780                 


Leu Gly Gly Phe Pro Glu Val Gly Ser Pro Ala Ser Pro Pro Ala Ser 
785                 790                 795                 800 


Gly Gly Leu Thr Glu Glu Pro Leu Gly Pro Met Glu Gly Glu Leu Pro 
                805                 810                 815     


Gly Glu Ala Cys Thr Leu Thr Ala His Glu Gly Arg Gly Gly Lys Cys 
            820                 825                 830         


Thr Glu Glu Gly Asp Ala Ser Gln Gln Glu Gly Cys Thr Leu Gly Ser 
        835                 840                 845             


Asp Pro Ile Cys Leu Ser Glu Ser Gln Val Ser Glu Glu Gln Glu Glu 
    850                 855                 860                 


Met Gly Gly Gln Ser Ser Ala Ala Gln Ala Thr Ala Ser Val Asn Ala 
865                 870                 875                 880 


Glu Glu Ile Lys Val Ala Arg Ile His Glu Cys Gln Trp Val Val Glu 
                885                 890                 895     


Asp Ala Pro Asn Pro Asp Val Leu Leu Ser His Lys Asp Asp Val Lys 
            900                 905                 910         


Glu Gly Glu Gly Gly Gln Glu Ser Phe Pro Glu Leu Pro Ser Glu Glu 
        915                 920                 925             


<210>  3793
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM129B__Homo_sapiens__NP_001030611

<400>  3793

Met Gly Trp Met Gly Glu Lys Thr Gly Lys Ile Leu Thr Glu Phe Leu 
1               5                   10                  15      


Gln Phe Tyr Glu Asp Gln Tyr Gly Val Ala Leu Phe Asn Ser Met Arg 
            20                  25                  30          


His Glu Ile Glu Gly Thr Gly Leu Pro Gln Ala Gln Leu Leu Trp Arg 
        35                  40                  45              


Lys Val Pro Leu Asp Glu Arg Ile Val Phe Ser Gly Asn Leu Phe Gln 
    50                  55                  60                  


His Gln Glu Asp Ser Lys Lys Trp Arg Asn Arg Phe Ser Leu Val Pro 
65                  70                  75                  80  


His Asn Tyr Gly Leu Val Leu Tyr Glu Asn Lys Ala Ala Tyr Glu Arg 
                85                  90                  95      


Gln Val Pro Pro Arg Ala Val Ile Asn Ser Ala Gly Tyr Lys Ile Leu 
            100                 105                 110         


Thr Ser Val Asp Gln Tyr Leu Glu Leu Ile Gly Asn Ser Leu Pro Gly 
        115                 120                 125             


Thr Thr Ala Lys Ser Gly Ser Ala Pro Ile Leu Lys Cys Pro Thr Gln 
    130                 135                 140                 


Phe Pro Leu Ile Leu Trp His Pro Tyr Ala Arg His Tyr Tyr Phe Cys 
145                 150                 155                 160 


Met Met Thr Glu Ala Glu Gln Asp Lys Trp Gln Ala Val Leu Gln Asp 
                165                 170                 175     


Cys Ile Arg His Cys Asn Asn Gly Ile Pro Glu Asp Ser Lys Val Glu 
            180                 185                 190         


Gly Pro Ala Phe Thr Asp Ala Ile Arg Met Tyr Arg Gln Ser Lys Glu 
        195                 200                 205             


Leu Tyr Gly Thr Trp Glu Met Leu Cys Gly Asn Glu Val Gln Ile Leu 
    210                 215                 220                 


Ser Asn Leu Val Met Glu Glu Leu Gly Pro Glu Leu Lys Ala Glu Leu 
225                 230                 235                 240 


Gly Pro Arg Leu Lys Gly Lys Pro Gln Glu Arg Gln Arg Gln Trp Ile 
                245                 250                 255     


Gln Ile Ser Asp Ala Val Tyr His Met Val Tyr Glu Gln Ala Lys Ala 
            260                 265                 270         


Arg Phe Glu Glu Val Leu Ser Lys Val Gln Gln Val Gln Pro Ala Met 
        275                 280                 285             


Gln Ala Val Ile Arg Thr Asp Met Asp Gln Ile Ile Thr Ser Lys Glu 
    290                 295                 300                 


His Leu Ala Ser Lys Ile Arg Ala Phe Ile Leu Pro Lys Ala Glu Val 
305                 310                 315                 320 


Cys Val Arg Asn His Val Gln Pro Tyr Ile Pro Ser Ile Leu Glu Ala 
                325                 330                 335     


Leu Met Val Pro Thr Ser Gln Gly Phe Thr Glu Val Arg Asp Val Phe 
            340                 345                 350         


Phe Lys Glu Val Thr Asp Met Asn Leu Asn Val Ile Asn Glu Gly Gly 
        355                 360                 365             


Ile Asp Lys Leu Gly Glu Tyr Met Glu Lys Leu Ser Arg Leu Ala Tyr 
    370                 375                 380                 


His Pro Leu Lys Met Gln Ser Cys Tyr Glu Lys Met Glu Ser Leu Arg 
385                 390                 395                 400 


Leu Asp Gly Leu Gln Gln Arg Phe Asp Val Ser Ser Thr Ser Val Phe 
                405                 410                 415     


Lys Gln Arg Ala Gln Ile His Met Arg Glu Gln Met Asp Asn Ala Val 
            420                 425                 430         


Tyr Thr Phe Glu Thr Leu Leu His Gln Glu Leu Gly Lys Gly Pro Thr 
        435                 440                 445             


Lys Glu Glu Leu Cys Lys Ser Ile Gln Arg Val Leu Glu Arg Val Leu 
    450                 455                 460                 


Lys Lys Tyr Asp Tyr Asp Ser Ser Ser Val Arg Lys Arg Phe Phe Arg 
465                 470                 475                 480 


Glu Ala Leu Leu Gln Ile Ser Ile Pro Phe Leu Leu Lys Lys Leu Ala 
                485                 490                 495     


Pro Thr Cys Lys Ser Glu Leu Pro Arg Phe Gln Glu Leu Ile Phe Glu 
            500                 505                 510         


Asp Phe Ala Arg Phe Ile Leu Val Glu Asn Thr Tyr Glu Glu Val Val 
        515                 520                 525             


Leu Gln Thr Val Met Lys Asp Ile Leu Gln Ala Val Lys Glu Ala Ala 
    530                 535                 540                 


Val Gln Arg Lys His Asn Leu Tyr Arg Asp Ser Met Val Met His Asn 
545                 550                 555                 560 


Ser Asp Pro Asn Leu His Leu Leu Ala Glu Gly Ala Pro Ile Asp Trp 
                565                 570                 575     


Gly Glu Glu Tyr Ser Asn Ser Gly Gly Gly Gly Ser Pro Ser Pro Ser 
            580                 585                 590         


Thr Pro Glu Ser Ala Thr Leu Ser Glu Lys Arg Arg Arg Ala Lys Gln 
        595                 600                 605             


Val Val Ser Val Val Gln Asp Glu Glu Val Gly Leu Pro Phe Glu Ala 
    610                 615                 620                 


Ser Pro Glu Ser Pro Pro Pro Ala Ser Pro Asp Gly Val Thr Glu Ile 
625                 630                 635                 640 


Arg Gly Leu Leu Ala Gln Gly Leu Arg Pro Glu Ser Pro Pro Pro Ala 
                645                 650                 655     


Gly Pro Leu Leu Asn Gly Ala Pro Ala Gly Glu Ser Pro Gln Pro Lys 
            660                 665                 670         


Ala Ala Pro Glu Ala Ser Ser Pro Pro Ala Ser Pro Leu Gln His Leu 
        675                 680                 685             


Leu Pro Gly Lys Ala Val Asp Leu Gly Pro Pro Lys Pro Ser Asp Gln 
    690                 695                 700                 


Glu Thr Gly Glu Gln Val Ser Ser Pro Ser Ser His Pro Ala Leu His 
705                 710                 715                 720 


Thr Thr Thr Glu Asp Ser Ala Gly Val Gln Thr Glu Phe 
                725                 730             


<210>  3794
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM134B__Homo_sapiens__NP_001030022

<400>  3794

Met Ala Ser Pro Ala Pro Pro Glu His Ala Glu Glu Gly Cys Pro Ala 
1               5                   10                  15      


Pro Ala Ala Glu Glu Gln Ala Pro Pro Ser Pro Pro Pro Pro Gln Ala 
            20                  25                  30          


Ser Pro Ala Glu Arg Gln Gln Gln Glu Glu Glu Ala Gln Glu Ala Gly 
        35                  40                  45              


Ala Ala Glu Gly Ala Gly Leu Gln Val Glu Glu Ala Ala Gly Arg Ala 
    50                  55                  60                  


Ala Ala Ala Val Thr Trp Leu Leu Gly Glu Pro Val Leu Trp Leu Gly 
65                  70                  75                  80  


Cys Arg Ala Asp Glu Leu Leu Ser Trp Lys Arg Pro Leu Arg Ser Leu 
                85                  90                  95      


Leu Gly Phe Val Ala Ala Asn Leu Leu Phe Trp Phe Leu Ala Leu Thr 
            100                 105                 110         


Pro Trp Arg Val Tyr His Leu Ile Ser Val Met Ile Leu Gly Arg Val 
        115                 120                 125             


Ile Met Gln Ile Ile Lys Asp Met Val Leu Ser Arg Thr Arg Gly Ala 
    130                 135                 140                 


Gln Leu Trp Arg Ser Leu Ser Glu Ser Trp Glu Val Ile Asn Ser Lys 
145                 150                 155                 160 


Pro Asp Glu Arg Pro Arg Leu Ser His Cys Ile Ala Glu Ser Trp Met 
                165                 170                 175     


Asn Phe Ser Ile Phe Leu Gln Glu Met Ser Leu Phe Lys Gln Gln Ser 
            180                 185                 190         


Pro Gly Lys Phe Cys Leu Leu Val Cys Ser Val Cys Thr Phe Phe Thr 
        195                 200                 205             


Ile Leu Gly Ser Tyr Ile Pro Gly Val Ile Leu Ser Tyr Leu Leu Leu 
    210                 215                 220                 


Leu Cys Ala Phe Leu Cys Pro Leu Phe Lys Cys Asn Asp Ile Gly Gln 
225                 230                 235                 240 


Lys Ile Tyr Ser Lys Ile Lys Ser Val Leu Leu Lys Leu Asp Phe Gly 
                245                 250                 255     


Ile Gly Glu Tyr Ile Asn Gln Lys Lys Arg Glu Arg Ser Glu Ala Asp 
            260                 265                 270         


Lys Glu Lys Ser His Lys Asp Asp Ser Glu Leu Asp Phe Ser Ala Leu 
        275                 280                 285             


Cys Pro Lys Ile Ser Leu Thr Val Ala Ala Lys Glu Leu Ser Val Ser 
    290                 295                 300                 


Asp Thr Asp Val Ser Glu Val Ser Trp Thr Asp Asn Gly Thr Phe Asn 
305                 310                 315                 320 


Leu Ser Glu Gly Tyr Thr Pro Gln Thr Asp Thr Ser Asp Asp Leu Asp 
                325                 330                 335     


Arg Pro Ser Glu Glu Val Phe Ser Arg Asp Leu Ser Asp Phe Pro Ser 
            340                 345                 350         


Leu Glu Asn Gly Met Gly Thr Asn Asp Glu Asp Glu Leu Ser Leu Gly 
        355                 360                 365             


Leu Pro Thr Glu Leu Lys Arg Lys Lys Glu Gln Leu Asp Ser Gly His 
    370                 375                 380                 


Arg Pro Ser Lys Glu Thr Gln Ser Ala Ala Gly Leu Thr Leu Pro Leu 
385                 390                 395                 400 


Asn Ser Asp Gln Thr Phe His Leu Met Ser Asn Leu Ala Gly Asp Val 
                405                 410                 415     


Ile Thr Ala Ala Val Thr Ala Ala Ile Lys Asp Gln Leu Glu Gly Val 
            420                 425                 430         


Gln Gln Ala Leu Ser Gln Ala Ala Pro Ile Pro Glu Glu Asp Thr Asp 
        435                 440                 445             


Thr Glu Glu Gly Asp Asp Phe Glu Leu Leu Asp Gln Ser Glu Leu Asp 
    450                 455                 460                 


Gln Ile Glu Ser Glu Leu Gly Leu Thr Gln Asp Gln Glu Ala Glu Ala 
465                 470                 475                 480 


Gln Gln Asn Lys Lys Ser Ser Gly Phe Leu Ser Asn Leu Leu Gly Gly 
                485                 490                 495     


His 
    


<210>  3795
<211>  1319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM135A__Homo_sapiens__NP_001099001

<400>  3795

Met Thr Glu Val Gln Ala Met Val Glu Phe Ser Val Glu Leu Asn Lys 
1               5                   10                  15      


Phe Tyr Asn Val Asp Leu Phe Gln Arg Gly Phe Tyr Gln Ile Arg Ala 
            20                  25                  30          


Ser Met Lys Ile Pro Ser Arg Ile Pro His Arg Val Glu Ala Ser Leu 
        35                  40                  45              


Leu His Ala Thr Gly Met Thr Leu Ala Phe Pro Ala Ser Val His Asp 
    50                  55                  60                  


Ser Leu Ile Cys Ser Lys Thr Phe Gln Ile Leu Tyr Lys Asn Glu Glu 
65                  70                  75                  80  


Val Val Leu Asn Asp Val Met Ile Phe Lys Val Lys Met Leu Leu Asp 
                85                  90                  95      


Glu Arg Lys Ile Glu Glu Thr Leu Glu Glu Met Asn Phe Leu Leu Ser 
            100                 105                 110         


Leu Asp Leu His Phe Thr Asp Gly Asp Tyr Ser Ala Asp Asp Leu Asn 
        115                 120                 125             


Ala Leu Gln Leu Ile Ser Ser Arg Thr Leu Lys Leu His Phe Ser Pro 
    130                 135                 140                 


His Arg Gly Leu His His His Val Asn Val Met Phe Asp Tyr Phe His 
145                 150                 155                 160 


Leu Ser Val Val Ser Val Thr Val His Ala Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Pro Leu Ile Ser Phe Pro Arg Pro Val Lys Thr Thr Trp Leu Asn 
            180                 185                 190         


Arg Asn Ala Pro Ala Gln Asn Lys Asp Ser Val Ile Pro Thr Leu Glu 
        195                 200                 205             


Ser Val Val Phe Gly Ile Asn Tyr Thr Lys Gln Leu Ser Pro Asp Gly 
    210                 215                 220                 


Cys Ser Phe Ile Ile Ala Asp Ser Phe Leu His His Ala Tyr Arg Phe 
225                 230                 235                 240 


His Tyr Thr Leu Cys Ala Thr Leu Leu Leu Ala Phe Lys Gly Leu His 
                245                 250                 255     


Ser Tyr Phe Ile Thr Val Thr Glu Glu Ile Pro Ser Cys Gln Lys Leu 
            260                 265                 270         


Glu Leu Glu Glu Met Asp Val Glu Ala Arg Leu Thr Glu Leu Cys Glu 
        275                 280                 285             


Glu Val Lys Lys Ile Glu Asn Pro Asp Glu Leu Ala Glu Leu Ile Asn 
    290                 295                 300                 


Met Asn Leu Ala Gln Leu Cys Ser Leu Leu Met Ala Leu Trp Gly Gln 
305                 310                 315                 320 


Phe Leu Glu Val Ile Thr Leu His Glu Glu Leu Arg Ile Leu Leu Ala 
                325                 330                 335     


Gln Glu His His Thr Leu Arg Val Arg Arg Phe Ser Glu Ala Phe Phe 
            340                 345                 350         


Cys Phe Glu His Pro Arg Glu Ala Ala Ile Ala Tyr Gln Glu Leu His 
        355                 360                 365             


Ala Gln Ser His Leu Gln Met Cys Thr Ala Ile Lys Asn Thr Ser Phe 
    370                 375                 380                 


Cys Ser Ser Leu Pro Pro Leu Pro Ile Glu Cys Ser Glu Leu Asp Gly 
385                 390                 395                 400 


Asp Leu Asn Ser Leu Pro Ile Ile Phe Glu Asp Arg Tyr Leu Asp Ser 
                405                 410                 415     


Val Thr Glu Gly Lys Leu Asp Ile Ser Gln Asp Asp Ser Glu Ile Thr 
            420                 425                 430         


Gln Met Glu His Asn Leu Ala Ser Arg Arg Ser Ser Asp Asp Cys His 
        435                 440                 445             


Asp His Gln Thr Thr Pro Ser Leu Gly Val Arg Thr Ile Glu Ile Lys 
    450                 455                 460                 


Pro Ser Asn Lys Asp Pro Phe Ser Gly Glu Asn Ile Thr Val Lys Leu 
465                 470                 475                 480 


Gly Pro Trp Thr Glu Leu Arg Gln Glu Glu Ile Leu Val Asp Asn Leu 
                485                 490                 495     


Leu Pro Asn Phe Glu Ser Leu Glu Ser Asn Gly Lys Ser Lys Ser Ile 
            500                 505                 510         


Glu Ile Thr Phe Glu Lys Glu Ala Leu Gln Glu Ala Lys Cys Leu Ser 
        515                 520                 525             


Ile Gly Glu Ser Leu Thr Lys Leu Arg Ser Asn Leu Pro Ala Pro Ser 
    530                 535                 540                 


Thr Lys Glu Tyr His Val Val Val Ser Gly Asp Thr Ile Lys Leu Pro 
545                 550                 555                 560 


Asp Ile Ser Ala Thr Tyr Ala Ser Ser Arg Phe Ser Asp Ser Gly Val 
                565                 570                 575     


Glu Ser Glu Pro Ser Ser Phe Ala Thr His Pro Asn Thr Asp Leu Val 
            580                 585                 590         


Phe Glu Thr Val Gln Gly Gln Gly Pro Cys Asn Ser Glu Arg Leu Phe 
        595                 600                 605             


Pro Gln Leu Leu Met Lys Pro Asp Tyr Asn Val Lys Phe Ser Leu Gly 
    610                 615                 620                 


Asn His Cys Thr Glu Ser Thr Ser Ala Ile Ser Glu Ile Gln Ser Ser 
625                 630                 635                 640 


Leu Thr Ser Ile Asn Ser Leu Pro Ser Asp Asp Glu Leu Ser Pro Asp 
                645                 650                 655     


Glu Asn Ser Lys Lys Ser Val Val Pro Glu Cys His Leu Asn Asp Ser 
            660                 665                 670         


Lys Thr Val Leu Asn Leu Gly Thr Thr Asp Leu Pro Lys Cys Asp Asp 
        675                 680                 685             


Thr Lys Lys Ser Ser Ile Thr Leu Gln Gln Gln Ser Val Val Phe Ser 
    690                 695                 700                 


Gly Asn Leu Asp Asn Glu Thr Val Ala Ile His Ser Leu Asn Ser Ser 
705                 710                 715                 720 


Ile Lys Asp Pro Leu Gln Phe Val Phe Ser Asp Glu Glu Thr Ser Ser 
                725                 730                 735     


Asp Val Lys Ser Ser Cys Ser Ser Lys Pro Asn Leu Asp Thr Met Cys 
            740                 745                 750         


Lys Gly Phe Gln Ser Pro Asp Lys Ser Asn Asn Ser Thr Gly Thr Ala 
        755                 760                 765             


Ile Thr Leu Asn Ser Lys Leu Ile Cys Leu Gly Thr Pro Cys Val Ile 
    770                 775                 780                 


Ser Gly Ser Ile Ser Ser Asn Thr Asp Val Ser Glu Asp Arg Thr Met 
785                 790                 795                 800 


Lys Lys Asn Ser Asp Val Leu Asn Leu Thr Gln Met Tyr Ser Glu Ile 
                805                 810                 815     


Pro Thr Val Glu Ser Glu Thr His Leu Gly Thr Ser Asp Pro Phe Ser 
            820                 825                 830         


Ala Ser Thr Asp Ile Val Lys Gln Gly Leu Val Glu Asn Tyr Phe Gly 
        835                 840                 845             


Ser Gln Ser Ser Thr Asp Ile Ser Asp Thr Cys Ala Val Ser Tyr Ser 
    850                 855                 860                 


Asn Ala Leu Ser Pro Gln Lys Glu Thr Ser Glu Lys Glu Ile Ser Asn 
865                 870                 875                 880 


Leu Gln Gln Glu Gln Asp Lys Glu Asp Glu Glu Glu Glu Gln Asp Gln 
                885                 890                 895     


Gln Met Val Gln Asn Gly Tyr Tyr Glu Glu Thr Asp Tyr Ser Ala Leu 
            900                 905                 910         


Asp Gly Thr Ile Asn Ala His Tyr Thr Ser Arg Asp Glu Leu Met Glu 
        915                 920                 925             


Glu Arg Leu Thr Lys Ser Glu Lys Ile Asn Ser Asp Tyr Leu Arg Asp 
    930                 935                 940                 


Gly Ile Asn Met Pro Thr Val Cys Thr Ser Gly Cys Leu Ser Phe Pro 
945                 950                 955                 960 


Ser Ala Pro Arg Glu Ser Pro Cys Asn Val Lys Tyr Ser Ser Lys Ser 
                965                 970                 975     


Lys Phe Asp Ala Ile Thr Lys Gln Pro Ser Ser Thr Ser Tyr Asn Phe 
            980                 985                 990         


Thr Ser Ser Ile Ser Trp Tyr Glu  Ser Ser Pro Lys Pro  Gln Ile Gln 
        995                 1000                 1005             


Ala Phe  Leu Gln Ala Lys Glu  Glu Leu Lys Leu Leu  Lys Leu Pro 
    1010                 1015                 1020             


Gly Phe  Met Tyr Ser Glu Val  Pro Leu Leu Ala Ser  Ser Val Pro 
    1025                 1030                 1035             


Tyr Phe  Ser Val Glu Glu Glu  Asp Gly Ser Glu Asp  Gly Val His 
    1040                 1045                 1050             


Leu Ile  Val Cys Val His Gly  Leu Asp Gly Asn Ser  Ala Asp Leu 
    1055                 1060                 1065             


Arg Leu  Val Lys Thr Tyr Ile  Glu Leu Gly Leu Pro  Gly Gly Arg 
    1070                 1075                 1080             


Ile Asp  Phe Leu Met Ser Glu  Arg Asn Gln Asn Asp  Thr Phe Ala 
    1085                 1090                 1095             


Asp Phe  Asp Ser Met Thr Asp  Arg Leu Leu Asp Glu  Ile Ile Gln 
    1100                 1105                 1110             


Tyr Ile  Gln Ile Tyr Ser Leu  Thr Val Ser Lys Ile  Ser Phe Ile 
    1115                 1120                 1125             


Gly His  Ser Leu Gly Asn Leu  Ile Ile Arg Ser Val  Leu Thr Arg 
    1130                 1135                 1140             


Pro Arg  Phe Lys Tyr Tyr Leu  Asn Lys Leu His Thr  Phe Leu Ser 
    1145                 1150                 1155             


Leu Ser  Gly Pro His Leu Gly  Thr Leu Tyr Asn Ser  Ser Ala Leu 
    1160                 1165                 1170             


Val Asn  Thr Gly Leu Trp Phe  Met Gln Lys Trp Lys  Lys Ser Gly 
    1175                 1180                 1185             


Ser Leu  Leu Gln Leu Thr Cys  Arg Asp His Ser Asp  Pro Arg Gln 
    1190                 1195                 1200             


Thr Phe  Leu Tyr Lys Leu Ser  Asn Lys Ala Gly Leu  His Tyr Phe 
    1205                 1210                 1215             


Lys Asn  Val Val Leu Val Gly  Ser Leu Gln Asp Arg  Tyr Val Pro 
    1220                 1225                 1230             


Tyr His  Ser Ala Arg Ile Glu  Met Cys Lys Thr Ala  Leu Lys Asp 
    1235                 1240                 1245             


Lys Gln  Ser Gly Gln Ile Tyr  Ser Glu Met Ile His  Asn Leu Leu 
    1250                 1255                 1260             


Arg Pro  Val Leu Gln Ser Lys  Asp Cys Asn Leu Val  Arg Tyr Asn 
    1265                 1270                 1275             


Val Ile  Asn Ala Leu Pro Asn  Thr Ala Asp Ser Leu  Ile Gly Arg 
    1280                 1285                 1290             


Ala Ala  His Ile Ala Val Leu  Asp Ser Glu Ile Phe  Leu Glu Lys 
    1295                 1300                 1305             


Phe Phe  Leu Val Ala Ala Leu  Lys Tyr Phe Gln 
    1310                 1315                 


<210>  3796
<211>  1406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM135B__Homo_sapiens__NP_056996

<400>  3796

Met Ser Glu Ile Gln Gly Thr Val Glu Phe Ser Val Glu Leu His Lys 
1               5                   10                  15      


Phe Tyr Asn Val Asp Leu Phe Gln Arg Gly Tyr Tyr Gln Ile Arg Val 
            20                  25                  30          


Thr Leu Lys Val Ser Ser Arg Ile Pro His Arg Leu Ser Ala Ser Ile 
        35                  40                  45              


Ala Gly Gln Thr Glu Ser Ser Ser Leu His Ser Ala Cys Val His Asp 
    50                  55                  60                  


Ser Thr Val His Ser Arg Val Phe Gln Ile Leu Tyr Arg Asn Glu Glu 
65                  70                  75                  80  


Val Pro Ile Asn Asp Ala Val Val Phe Arg Val His Leu Leu Leu Gly 
                85                  90                  95      


Gly Glu Arg Met Glu Asp Ala Leu Ser Glu Val Asp Phe Gln Leu Lys 
            100                 105                 110         


Val Asp Leu His Phe Thr Asp Ser Glu Gln Gln Leu Arg Asp Val Ala 
        115                 120                 125             


Gly Ala Pro Met Val Ser Ser Arg Thr Leu Gly Leu His Phe His Pro 
    130                 135                 140                 


Arg Asn Gly Leu His His Gln Val Pro Val Met Phe Asp Tyr Phe His 
145                 150                 155                 160 


Leu Ser Val Ile Ser Val Thr Val His Ala Ala Leu Val Ala Leu Gln 
                165                 170                 175     


Gln Pro Leu Ile Ser Phe Thr Arg Pro Gly Arg Gly Ser Trp Leu Gly 
            180                 185                 190         


Lys Gly Gly Pro Asp Thr Gly Gln Glu Gln Ser Ile Ile Ser Leu Glu 
        195                 200                 205             


Asn Leu Val Phe Gly Ala Gly Tyr Cys Lys Pro Thr Ser Ser Glu Gly 
    210                 215                 220                 


Ser Phe Tyr Ile Thr Ser Glu Asn Cys Met Gln His Ala His Lys Trp 
225                 230                 235                 240 


His Arg Asp Leu Cys Leu Leu Leu Leu His Ala Tyr Arg Gly Leu Arg 
                245                 250                 255     


Leu His Phe Leu Val Ile Met Arg Asp Ile Pro Glu Leu Pro His Thr 
            260                 265                 270         


Glu Leu Glu Ala Leu Ala Val Glu Glu Thr Leu Ser Gln Leu Cys Ser 
        275                 280                 285             


Glu Leu Gln Met Leu Asn Asn Pro Glu Lys Ile Ala Glu Gln Ile Ser 
    290                 295                 300                 


Lys Asp Leu Ala Trp Leu Thr Ser His Met Met Thr Leu Trp Thr Gln 
305                 310                 315                 320 


Phe Leu Asp Thr Val Thr Leu His Ser Gln Val Thr Thr Tyr Leu Thr 
                325                 330                 335     


Gln Glu His His Thr Leu Arg Val Arg Arg Phe Ser Glu Ala Phe Phe 
            340                 345                 350         


Tyr Met Glu His Gln Lys Leu Ala Val Leu Thr Phe Gln Glu Asn Leu 
        355                 360                 365             


Ile Gln Thr His Ser Gln Leu Ser Leu Asp Ile Arg Asn Ser Glu Tyr 
    370                 375                 380                 


Leu Thr Ser Met Pro Pro Leu Pro Ala Glu Cys Leu Asp Ile Asp Gly 
385                 390                 395                 400 


Asp Trp Asn Thr Leu Pro Val Ile Phe Glu Asp Arg Tyr Val Asp Cys 
                405                 410                 415     


Pro Ala Thr Gly His Asn Leu Ser Val Tyr Pro Asn Phe Asp Val Pro 
            420                 425                 430         


Val Thr Ser Pro Thr Ile Met Asn Leu Lys Asp Lys Glu Asp Asn Cys 
        435                 440                 445             


Met Val Asn Ser Asn Leu Ser Phe Arg Glu Asp Leu Val Leu Ser Thr 
    450                 455                 460                 


Ile Lys Pro Ser Gln Met Asp Ser Asp Glu Glu Val Ile Arg Cys Pro 
465                 470                 475                 480 


Glu Pro Gly Glu Asn Val Ala Thr Gln Asn His Met Asp Met Cys Ser 
                485                 490                 495     


Glu Ser Gln Val Tyr Ile Ser Ile Gly Glu Phe Gln Asn Lys Ala Gly 
            500                 505                 510         


Val Pro Glu Asp Glu Cys Trp Thr Gly Gln Thr Ser Asp Ala Gly Thr 
        515                 520                 525             


Tyr Pro Val Ala Asp Val Asp Thr Ser Arg Arg Ser Pro Gly Pro Glu 
    530                 535                 540                 


Asp Gly Gln Ala Pro Val Leu Thr Tyr Ile Asp Val Lys Ser Ser Asn 
545                 550                 555                 560 


Lys Asn Pro Ser Arg Ala Glu Pro Leu Val Ala Phe Asn Ala Gln His 
                565                 570                 575     


Glu Ser Arg Ser Ser Arg Asp Lys Tyr Gly Leu Asp Arg Thr Gly Leu 
            580                 585                 590         


Ser Lys Val Val Val Gly Gly Ser His Gln Asn Ala Ile Ser Ser Asp 
        595                 600                 605             


Lys Thr Thr Leu His Glu Leu Ser Thr Leu Gly Lys Gly Ile Asp Gln 
    610                 615                 620                 


Glu Gly Lys Met Val Leu Leu Ser Leu Lys Leu Thr Pro Ser Glu Pro 
625                 630                 635                 640 


Cys Asp Pro Leu Ser Ser Thr Leu Arg Glu Pro Leu Asp Ile Arg Ser 
                645                 650                 655     


Ser Leu Lys Asp Ser His Thr Glu Glu Gln Glu Glu Leu Ser Val Leu 
            660                 665                 670         


Ser Gly Val Ile Lys Arg Ser Ser Ser Ile Ile Ser Asp Ser Gly Ile 
        675                 680                 685             


Glu Ser Glu Pro Ser Ser Val Ala Trp Ser Glu Ala Arg Ser Arg Ala 
    690                 695                 700                 


Leu Glu Leu Pro Ser Asp Arg Glu Val Leu His Pro Phe Val Arg Arg 
705                 710                 715                 720 


His Ala Leu His Arg Asn Ser Leu Glu Gly Gly His Thr Glu Ser Asn 
                725                 730                 735     


Thr Ser Leu Pro Ser Gly Ile Gln Ala Ser Leu Thr Ser Ile Ser Ser 
            740                 745                 750         


Leu Pro Phe Glu Glu Asp Glu Arg Glu Val Ala Leu Thr Lys Leu Thr 
        755                 760                 765             


Lys Ser Val Ser Ala Pro His Ile Ser Ser Pro Glu Glu Ala Ala Glu 
    770                 775                 780                 


Asp Ala Asp Thr Lys Gln Gln Asp Gly Gly Phe Ala Glu Pro Ser Asp 
785                 790                 795                 800 


Met His Ser Lys Ser Gln Gly Ser Pro Gly Ser Cys Ser Gln Leu Cys 
                805                 810                 815     


Gly Asp Ser Gly Thr Asp Ala Gly Ala Asp His Pro Leu Val Glu Ile 
            820                 825                 830         


Val Leu Asp Ala Asp Asn Gln Gln Gly Pro Gly Tyr Ile Asp Ile Pro 
        835                 840                 845             


Lys Gly Lys Gly Lys Gln Phe Asp Ala Gln Gly His Cys Leu Pro Asp 
    850                 855                 860                 


Gly Arg Thr Glu Asn Thr Pro Gly Val Glu Thr Lys Gly Leu Asn Leu 
865                 870                 875                 880 


Lys Ile Pro Arg Val Ile Ala Leu Glu Asn Pro Arg Thr Arg Ser Leu 
                885                 890                 895     


His Arg Ala Leu Glu Glu Thr Pro Lys Gly Met Pro Lys Asp Leu Asn 
            900                 905                 910         


Val Gly Gln Gln Ala Leu Ser Asn Ser Gly Ile Ser Glu Val Glu Gly 
        915                 920                 925             


Leu Ser Gln His Gln Val Pro Glu Leu Ser Cys Thr Ser Ala Ala Asp 
    930                 935                 940                 


Ala Ile Asn Arg Asn Ser Thr Gly Gln Gln Ser Gln Ser Gly Ser Pro 
945                 950                 955                 960 


Cys Ile Met Asp Asp Thr Ala Phe Asn Arg Gly Val Asn Ala Phe Pro 
                965                 970                 975     


Glu Ala Lys His Lys Ala Gly Thr Val Cys Pro Thr Val Thr His Ser 
            980                 985                 990         


Val His Ser Gln Val Leu Lys Asn  Gln Glu Leu Lys Ala  Gly Thr Ser 
        995                 1000                 1005             


Ile Met  Gly Ser His Leu Thr  Ser Ala Glu Thr Phe  Thr Leu Asp 
    1010                 1015                 1020             


Ser Leu  Lys Ala Val Glu Val  Val Asn Leu Ser Val  Ser Cys Thr 
    1025                 1030                 1035             


Ala Thr  Cys Leu Pro Phe Ser  Ser Val Pro Lys Glu  Thr Pro Ala 
    1040                 1045                 1050             


Arg Ala  Gly Phe Ser Ser Lys  Gln Thr Leu Phe Pro  Ile Thr His 
    1055                 1060                 1065             


Gln Pro  Leu Gly Ser Phe Gly  Val Val Ser Thr His  Ser Ser Thr 
    1070                 1075                 1080             


Leu Asp  Glu Glu Val Ser Glu  Arg Met Phe Ser Phe  Tyr Gln Ala 
    1085                 1090                 1095             


Lys Glu  Lys Phe Lys Lys Glu  Leu Lys Ile Glu Gly  Phe Leu Tyr 
    1100                 1105                 1110             


Ser Asp  Leu Thr Val Leu Ala  Ser Asp Ile Pro Tyr  Phe Pro Pro 
    1115                 1120                 1125             


Glu Glu  Glu Glu Glu Asn Leu  Glu Asp Gly Ile His  Leu Val Val 
    1130                 1135                 1140             


Cys Val  His Gly Leu Asp Gly  Asn Ser Ala Asp Leu  Arg Leu Val 
    1145                 1150                 1155             


Lys Thr  Phe Ile Glu Leu Gly  Leu Pro Gly Gly Lys  Leu Asp Phe 
    1160                 1165                 1170             


Leu Met  Ser Glu Lys Asn Gln  Met Asp Thr Phe Ala  Asp Phe Asp 
    1175                 1180                 1185             


Thr Met  Thr Asp Arg Leu Leu  Asp Glu Ile Ile Gln  His Ile Gln 
    1190                 1195                 1200             


Leu Tyr  Asn Leu Ser Ile Ser  Arg Ile Ser Phe Ile  Gly His Ser 
    1205                 1210                 1215             


Leu Gly  Asn Ile Ile Ile Arg  Ser Val Leu Thr Arg  Pro Arg Phe 
    1220                 1225                 1230             


Arg Tyr  Tyr Leu Asn Lys Leu  His Thr Phe Leu Ser  Leu Ser Gly 
    1235                 1240                 1245             


Pro His  Leu Gly Thr Leu Tyr  Asn Asn Ser Thr Leu  Val Ser Thr 
    1250                 1255                 1260             


Gly Leu  Trp Leu Met Gln Lys  Leu Lys Lys Ser Gly  Ser Leu Leu 
    1265                 1270                 1275             


Gln Leu  Thr Phe Arg Asp Asn  Ala Asp Leu Arg Lys  Cys Phe Leu 
    1280                 1285                 1290             


Tyr Gln  Leu Ser Gln Lys Thr  Gly Leu Gln Tyr Phe  Lys Asn Val 
    1295                 1300                 1305             


Val Leu  Val Ala Ser Pro Gln  Asp Arg Tyr Val Pro  Phe His Ser 
    1310                 1315                 1320             


Ala Arg  Ile Glu Met Cys Lys  Thr Ala Leu Lys Asp  Arg His Thr 
    1325                 1330                 1335             


Gly Pro  Val Tyr Ala Glu Met  Ile Asn Asn Leu Leu  Gly Pro Leu 
    1340                 1345                 1350             


Val Glu  Ala Lys Asp Cys Thr  Leu Ile Arg His Asn  Val Phe His 
    1355                 1360                 1365             


Ala Leu  Pro Asn Thr Ala Asn  Thr Leu Ile Gly Arg  Ala Ala His 
    1370                 1375                 1380             


Ile Ala  Val Leu Asp Ser Glu  Leu Phe Leu Glu Lys  Phe Phe Leu 
    1385                 1390                 1395             


Val Ala  Gly Leu Asn Tyr Phe  Lys 
    1400                 1405     


<210>  3797
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM136A__Homo_sapiens__NP_116211

<400>  3797

Met Ala Glu Leu Gln Gln Leu Arg Val Gln Glu Ala Val Glu Ser Met 
1               5                   10                  15      


Val Lys Ser Leu Glu Arg Glu Asn Ile Arg Lys Met Gln Gly Leu Met 
            20                  25                  30          


Phe Arg Cys Ser Ala Ser Cys Cys Glu Asp Ser Gln Ala Ser Met Lys 
        35                  40                  45              


Gln Val His Gln Cys Ile Glu Arg Cys His Val Pro Leu Ala Gln Ala 
    50                  55                  60                  


Gln Ala Leu Val Thr Ser Glu Leu Glu Lys Phe Gln Asp Arg Leu Ala 
65                  70                  75                  80  


Arg Cys Thr Met His Cys Asn Asp Lys Ala Lys Asp Ser Ile Asp Ala 
                85                  90                  95      


Gly Ser Lys Glu Leu Gln Val Lys Gln Gln Leu Asp Ser Cys Val Thr 
            100                 105                 110         


Lys Cys Val Asp Asp His Met His Leu Ile Pro Thr Met Thr Lys Lys 
        115                 120                 125             


Met Lys Glu Ala Leu Leu Ser Ile Gly Lys 
    130                 135             


<210>  3798
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM13A__Homo_sapiens__NP_001015045

<400>  3798

Met Ala Cys Glu Ile Met Pro Leu Gln Ser Ser Gln Glu Asp Glu Arg 
1               5                   10                  15      


Pro Leu Ser Pro Phe Tyr Leu Ser Ala His Val Pro Gln Val Ser Asn 
            20                  25                  30          


Val Ser Ala Thr Gly Glu Leu Leu Glu Arg Thr Ile Arg Ser Ala Val 
        35                  40                  45              


Glu Gln His Leu Phe Asp Val Asn Asn Ser Gly Gly Gln Ser Ser Glu 
    50                  55                  60                  


Asp Ser Glu Ser Gly Thr Leu Ser Ala Ser Ser Ala Thr Ser Ala Arg 
65                  70                  75                  80  


Gln Arg Arg Arg Gln Ser Lys Glu Gln Asp Glu Val Arg His Gly Arg 
                85                  90                  95      


Asp Lys Gly Leu Ile Asn Lys Glu Asn Thr Pro Ser Gly Phe Asn His 
            100                 105                 110         


Leu Asp Asp Cys Ile Leu Asn Thr Gln Glu Val Glu Lys Val His Lys 
        115                 120                 125             


Asn Thr Phe Gly Cys Ala Gly Glu Arg Ser Lys Pro Lys Arg Gln Lys 
    130                 135                 140                 


Ser Ser Thr Lys Leu Ser Glu Leu His Asp Asn Gln Asp Gly Leu Val 
145                 150                 155                 160 


Asn Met Glu Ser Leu Asn Ser Thr Arg Ser His Glu Arg Thr Gly Pro 
                165                 170                 175     


Asp Asp Phe Glu Trp Met Ser Asp Glu Arg Lys Gly Asn Glu Lys Asp 
            180                 185                 190         


Gly Gly His Thr Gln His Phe Glu Ser Pro Thr Met Lys Ile Gln Glu 
        195                 200                 205             


His Pro Ser Leu Ser Asp Thr Lys Gln Gln Arg Asn Gln Asp Ala Gly 
    210                 215                 220                 


Asp Gln Glu Glu Ser Phe Val Ser Glu Val Pro Gln Ser Asp Leu Thr 
225                 230                 235                 240 


Ala Leu Cys Asp Glu Lys Asn Trp Glu Glu Pro Ile Pro Ala Phe Ser 
                245                 250                 255     


Ser Trp Gln Arg Glu Asn Ser Asp Ser Asp Glu Ala His Leu Ser Pro 
            260                 265                 270         


Gln Ala Gly Arg Leu Ile Arg Gln Leu Leu Asp Glu Asp Ser Asp Pro 
        275                 280                 285             


Met Leu Ser Pro Arg Phe Tyr Ala Tyr Gly Gln Ser Arg Gln Tyr Leu 
    290                 295                 300                 


Asp Asp Thr Glu Val Pro Pro Ser Pro Pro Asn Ser His Ser Phe Met 
305                 310                 315                 320 


Arg Arg Arg Ser Ser Ser Leu Gly Ser Tyr Asp Asp Glu Gln Glu Asp 
                325                 330                 335     


Leu Thr Pro Ala Gln Leu Thr Arg Arg Ile Gln Ser Leu Lys Lys Lys 
            340                 345                 350         


Ile Arg Lys Phe Glu Asp Arg Phe Glu Glu Glu Lys Lys Tyr Arg Pro 
        355                 360                 365             


Ser His Ser Asp Lys Ala Ala Asn Pro Glu Val Leu Lys Trp Thr Asn 
    370                 375                 380                 


Asp Leu Ala Lys Phe Arg Arg Gln Leu Lys Glu Ser Lys Leu Lys Ile 
385                 390                 395                 400 


Ser Glu Glu Asp Leu Thr Pro Arg Met Arg Gln Arg Ser Asn Thr Leu 
                405                 410                 415     


Pro Lys Ser Phe Gly Ser Gln Leu Glu Lys Glu Asp Glu Lys Lys Gln 
            420                 425                 430         


Glu Leu Val Asp Lys Ala Ile Lys Pro Ser Val Glu Ala Thr Leu Glu 
        435                 440                 445             


Ser Ile Gln Arg Lys Leu Gln Glu Lys Arg Ala Glu Ser Ser Arg Pro 
    450                 455                 460                 


Glu Asp Ile Lys Asp Met Thr Lys Asp Gln Ile Ala Asn Glu Lys Val 
465                 470                 475                 480 


Ala Leu Gln Lys Ala Leu Leu Tyr Tyr Glu Ser Ile His Gly Arg Pro 
                485                 490                 495     


Val Thr Lys Asn Glu Arg Gln Val Met Lys Pro Leu Tyr Asp Arg Tyr 
            500                 505                 510         


Arg Leu Val Lys Gln Ile Leu Ser Arg Ala Asn Thr Ile Pro Ile Ile 
        515                 520                 525             


Gly Ser Pro Ser Ser Lys Arg Arg Ser Pro Leu Leu Gln Pro Ile Ile 
    530                 535                 540                 


Glu Gly Glu Thr Ala Ser Phe Phe Lys Glu Ile Lys Glu Glu Glu Glu 
545                 550                 555                 560 


Gly Ser Glu Asp Asp Ser Asn Val Lys Pro Asp Phe Met Val Thr Leu 
                565                 570                 575     


Lys Thr Asp Phe Ser Ala Arg Cys Phe Leu Asp Gln Phe Glu Asp Asp 
            580                 585                 590         


Ala Asp Gly Phe Ile Ser Pro Met Asp Asp Lys Ile Pro Ser Lys Cys 
        595                 600                 605             


Ser Gln Asp Thr Gly Leu Ser Asn Leu His Ala Ala Ser Ile Pro Glu 
    610                 615                 620                 


Leu Leu Glu His Leu Gln Glu Met Arg Glu Glu Lys Lys Arg Ile Arg 
625                 630                 635                 640 


Lys Lys Leu Arg Asp Phe Glu Asp Asn Phe Phe Arg Gln Asn Gly Arg 
                645                 650                 655     


Asn Val Gln Lys Glu Asp Arg Thr Pro Met Ala Glu Glu Tyr Ser Glu 
            660                 665                 670         


Tyr Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu Val Leu Ile Ser 
        675                 680                 685             


Lys Arg Asp Thr Asp Ser Lys Ser Met 
    690                 695         


<210>  3799
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM13C__Homo_sapiens__NP_001001971

<400>  3799

Met Phe Ser Cys Phe Cys Phe Ser Leu Gln Asp Asn Ser Phe Ser Ser 
1               5                   10                  15      


Thr Thr Val Thr Glu Cys Asp Glu Asp Pro Val Ser Leu His Glu Asp 
            20                  25                  30          


Gln Thr Asp Cys Ser Ser Leu Arg Asp Glu Asn Asn Lys Glu Asn Tyr 
        35                  40                  45              


Pro Asp Ala Gly Ala Leu Val Glu Glu His Ala Pro Pro Ser Trp Glu 
    50                  55                  60                  


Pro Gln Gln Gln Asn Val Glu Ala Thr Val Leu Val Asp Ser Val Leu 
65                  70                  75                  80  


Arg Pro Ser Met Gly Asn Phe Lys Ser Arg Lys Pro Lys Ser Ile Phe 
                85                  90                  95      


Lys Ala Glu Ser Gly Arg Ser His Gly Glu Ser Gln Glu Thr Glu His 
            100                 105                 110         


Val Val Ser Ser Gln Ser Glu Cys Gln Val Arg Ala Gly Thr Pro Ala 
        115                 120                 125             


His Glu Ser Pro Gln Asn Asn Ala Phe Lys Cys Gln Glu Thr Val Arg 
    130                 135                 140                 


Leu Gln Pro Arg Ile Asp Gln Arg Thr Ala Ile Ser Pro Lys Asp Ala 
145                 150                 155                 160 


Phe Glu Thr Arg Gln Asp Leu Asn Glu Glu Glu Ala Ala Gln Val His 
                165                 170                 175     


Gly Val Lys Asp Pro Ala Pro Ala Ser Thr Gln Ser Val Leu Ala Asp 
            180                 185                 190         


Gly Thr Asp Ser Ala Asp Pro Ser Pro Val His Lys Asp Gly Gln Asn 
        195                 200                 205             


Glu Ala Asp Ser Ala Pro Glu Asp Leu His Ser Val Gly Thr Ser Arg 
    210                 215                 220                 


Leu Leu Tyr His Ile Thr Asp Gly Asp Asn Pro Leu Leu Ser Pro Arg 
225                 230                 235                 240 


Cys Ser Ile Phe Ser Gln Ser Gln Arg Phe Asn Leu Asp Pro Glu Ser 
                245                 250                 255     


Ala Pro Ser Pro Pro Ser Thr Gln Gln Phe Met Met Pro Arg Ser Ser 
            260                 265                 270         


Ser Arg Cys Ser Cys Gly Asp Gly Lys Glu Pro Gln Thr Ile Thr Gln 
        275                 280                 285             


Leu Thr Lys His Ile Gln Ser Leu Lys Arg Lys Ile Arg Lys Phe Glu 
    290                 295                 300                 


Glu Lys Phe Glu Gln Glu Lys Lys Tyr Arg Val Thr Lys Gln Asp Lys 
305                 310                 315                 320 


Asn Leu Ile Lys Pro Leu Tyr Asp Arg Tyr Arg Ile Ile Lys Gln Ile 
                325                 330                 335     


Leu Ser Thr Pro Ser Leu Ile Pro Thr Ile Gln Glu Glu Glu Asp Ser 
            340                 345                 350         


Asp Glu Asp Arg Pro Gln Gly Ser Gln Gln Pro Ser Leu Ala Asp Pro 
        355                 360                 365             


Ala Ser His Leu Pro Val Gly Asp His Leu Thr Tyr Ser Asn Glu Thr 
    370                 375                 380                 


Glu Pro Val Arg Ala Leu Leu Pro Asp Glu Lys Lys Glu Val Lys Pro 
385                 390                 395                 400 


Pro Ala Leu Ser Met Ser Asn Leu His Glu Ala Thr Met Pro Val Leu 
                405                 410                 415     


Leu Asp His Leu Arg Glu Thr Arg Ala Asp Lys Lys Arg Leu Arg Lys 
            420                 425                 430         


Ala Leu Arg Glu Phe Glu Glu Gln Phe Phe Lys Gln Thr Gly Arg Ser 
        435                 440                 445             


Pro Gln Lys Glu Asp Arg Ile Pro Met Ala Asp Glu Tyr Tyr Glu Tyr 
    450                 455                 460                 


Lys His Ile Lys Ala Lys Leu Arg Leu Leu Glu Val Leu Ile Ser Lys 
465                 470                 475                 480 


Gln Asp Val Ala Lys Thr Ile 
                485         


<210>  3800
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM149A__Homo_sapiens__NP_056213

<400>  3800

Met Leu Phe Glu Gly Lys Val Asn Pro Gln Thr Gln Ser Leu Leu Ala 
1               5                   10                  15      


Glu Cys Gly Glu Trp Thr Arg Arg Ser Leu His Leu Arg Val Leu Gly 
            20                  25                  30          


Arg Gln Leu Ile Leu Pro Thr Asp Lys Gly Val Gln His Phe Gln Gly 
        35                  40                  45              


Ser Thr Pro Ala Ser Ala Val His Arg Pro Pro Leu Ser Ala Cys Gly 
    50                  55                  60                  


His Ser Ser Asn Ile Arg Glu Leu Cys Ile Ser Gly Ser Gln Ile Val 
65                  70                  75                  80  


Pro Ala Ala Leu Ser Ala Ser Ala Leu Pro Gly Pro Asp Asp Thr Gly 
                85                  90                  95      


Val Ala Asp Leu Thr Ala Arg Ser Ser Leu Glu Glu Glu Val Tyr His 
            100                 105                 110         


Val Asp Gly Lys Ile Glu Glu Tyr Phe Ala Phe Asp Arg Lys Glu Asp 
        115                 120                 125             


Asp Asp Glu Cys Leu Glu Gln Lys Pro Ala Gln Pro Gly Arg Lys Trp 
    130                 135                 140                 


Arg Lys Leu Gly Leu Pro Pro Val Ser Pro Arg Asp Cys Val Lys Asp 
145                 150                 155                 160 


Ala Val Ala Ala Glu Val Phe Asp His Val Trp Thr Asn Met Val Glu 
                165                 170                 175     


Leu Leu Glu Glu Leu Ile Arg Lys His Trp Glu Thr Thr Leu Thr Glu 
            180                 185                 190         


Gly Lys Lys Gln Arg Glu Thr Leu Lys Val Ala Gly Asn Arg Phe Pro 
        195                 200                 205             


His Val Leu Val Pro His Ala His Ala Asp Gly Ala Ser Gly Pro Pro 
    210                 215                 220                 


Ser Gly His Ala Glu Ala His Gly Ile Ser Leu Ala Ser Arg Leu Asn 
225                 230                 235                 240 


Pro Pro Gln Ile His His Phe Ser Ser Ser Phe Tyr Ser Asp Met Asn 
                245                 250                 255     


Gly Val Met Thr Ile Gln Ala Lys Pro Leu Gln Arg Arg Pro Ala Tyr 
            260                 265                 270         


Phe Ala Asp Arg Thr Gln Asn Glu Lys Glu Asp Lys Ala Ser Gly Gly 
        275                 280                 285             


Gly Ala Gly Ala Leu Ser Ser Ala Pro His Arg Leu Gly Arg Ala Ser 
    290                 295                 300                 


Asp Thr His Gly Leu Ser Pro Ser Ala Lys Lys Thr Pro Val Pro Trp 
305                 310                 315                 320 


Arg Leu Pro Ser Leu Ala Ser Asp Ser Gln Arg Leu Lys Thr Pro Asn 
                325                 330                 335     


Ile Tyr Ser Asp Glu Val Leu Arg Gly Thr Lys Leu Pro Thr Gly Val 
            340                 345                 350         


Asp His Met Ala Ser Pro Leu Val Gln Thr Ser Arg Ser Arg Phe Pro 
        355                 360                 365             


Pro Leu Val Thr Glu Thr Arg Gly Gln Asn Thr Ala Val Pro Gly Cys 
    370                 375                 380                 


Arg Leu Val Ser Tyr Arg Gly Arg His Leu Gln Asn Arg Val Leu Ser 
385                 390                 395                 400 


Ala Met Pro Asp Gly Thr Glu Arg Ser Arg Leu Arg Glu Arg Thr Ala 
                405                 410                 415     


Thr Leu Glu Arg Leu Ser Arg Pro Ser Thr Thr His Thr Phe Arg Gln 
            420                 425                 430         


Ser Asp Thr Pro Arg Lys Ser Ser Leu Thr Gln Met Glu Phe Ala Ala 
        435                 440                 445             


His Thr Trp Thr Gly Gln Ser Ile Leu Thr Gly Ser Gln Tyr Val Pro 
    450                 455                 460                 


Lys Ser Phe Gln Arg Thr Thr Leu Thr Phe Lys Arg Arg Phe Gln Val 
465                 470                 475                 480 


Thr Ser 
        


<210>  3801
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM150B__Homo_sapiens__NP_001002919

<400>  3801

Met Arg Gly Pro Gly His Pro Leu Leu Leu Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Ala Gly Arg Gly Arg Gly Gly Ala Glu Pro Arg Glu Pro Ala 
            20                  25                  30          


Asp Gly Gln Ala Leu Leu Arg Leu Val Val Glu Leu Val Gln Glu Leu 
        35                  40                  45              


Arg Lys His His Ser Ala Glu His Lys Gly Leu Gln Leu Leu Gly Arg 
    50                  55                  60                  


Asp Cys Ala Leu Gly Arg Ala Glu Ala Ala Gly Leu Gly Pro Ser Pro 
65                  70                  75                  80  


Glu Gln Arg Val Glu Ile Val Pro Arg Asp Leu Arg Met Lys Asp Lys 
                85                  90                  95      


Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser Pro Lys Cys Ser 
            100                 105                 110         


Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp Cys Thr Ile Pro 
        115                 120                 125             


Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser 
    130                 135                 140                 


Pro Val Cys Met Glu Asp Lys Gln 
145                 150         


<210>  3802
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM155A__Homo_sapiens__NP_001073865

<400>  3802

Met Thr Arg Gly Ala Trp Met Cys Arg Gln Tyr Asp Asp Gly Leu Lys 
1               5                   10                  15      


Ile Trp Leu Ala Ala Pro Arg Glu Asn Glu Lys Pro Phe Ile Asp Ser 
            20                  25                  30          


Glu Arg Ala Gln Lys Trp Arg Leu Ser Leu Ala Ser Leu Leu Phe Phe 
        35                  40                  45              


Thr Val Leu Leu Ser Asp His Leu Trp Phe Cys Ala Glu Ala Lys Leu 
    50                  55                  60                  


Thr Arg Ala Arg Asp Lys Glu His Gln Gln Gln Gln Arg Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Arg Gln Arg Gln Gln Gln Gln Gln Gln Arg 
                85                  90                  95      


Arg Gln Gln Glu Pro Ser Trp Pro Ala Leu Leu Ala Ser Met Gly Glu 
            100                 105                 110         


Ser Ser Pro Ala Ala Gln Ala His Arg Leu Leu Ser Ala Ser Ser Ser 
        115                 120                 125             


Pro Thr Leu Pro Pro Ser Pro Gly Asp Gly Gly Gly Gly Gly Gly Lys 
    130                 135                 140                 


Gly Asn Arg Gly Lys Asp Asp Arg Gly Lys Ala Leu Phe Leu Gly Asn 
145                 150                 155                 160 


Ser Ala Lys Pro Val Trp Arg Leu Glu Thr Cys Tyr Pro Gln Gly Ala 
                165                 170                 175     


Ser Ser Gly Gln Cys Phe Thr Val Glu Asn Ala Asp Ala Val Cys Ala 
            180                 185                 190         


Arg Asn Trp Ser Arg Gly Ala Ala Gly Gly Asp Gly Gln Glu Val Arg 
        195                 200                 205             


Ser Lys His Pro Thr Pro Leu Trp Asn Leu Ser Asp Phe Tyr Leu Ser 
    210                 215                 220                 


Phe Cys Asn Ser Tyr Thr Leu Trp Glu Leu Phe Ser Gly Leu Ser Ser 
225                 230                 235                 240 


Pro Asn Thr Leu Asn Cys Ser Leu Asp Val Val Leu Lys Glu Gly Gly 
                245                 250                 255     


Glu Met Thr Thr Cys Arg Gln Cys Val Glu Ala Tyr Gln Asp Tyr Asp 
            260                 265                 270         


His His Ala Gln Glu Lys Tyr Glu Glu Phe Glu Ser Val Leu His Lys 
        275                 280                 285             


Tyr Leu Gln Ser Glu Glu Tyr Ser Val Lys Ser Cys Pro Glu Asp Cys 
    290                 295                 300                 


Lys Ile Val Tyr Lys Ala Trp Leu Cys Ser Gln Tyr Phe Glu Val Thr 
305                 310                 315                 320 


Gln Phe Asn Cys Arg Lys Thr Ile Pro Cys Lys Gln Tyr Cys Leu Glu 
                325                 330                 335     


Val Gln Thr Arg Cys Pro Phe Ile Leu Pro Asp Asn Asp Glu Val Ile 
            340                 345                 350         


Tyr Gly Gly Leu Ser Ser Phe Ile Cys Thr Gly Leu Tyr Glu Thr Phe 
        355                 360                 365             


Leu Thr Asn Asp Glu Pro Glu Cys Cys Asp Val Arg Arg Glu Glu Lys 
    370                 375                 380                 


Ser Asn Asn Pro Ser Lys Gly Thr Val Glu Lys Ser Gly Ser Cys His 
385                 390                 395                 400 


Arg Thr Ser Leu Thr Val Ser Ser Ala Thr Arg Leu Cys Asn Ser Arg 
                405                 410                 415     


Leu Lys Leu Cys Val Leu Val Leu Ile Leu Leu His Thr Val Leu Thr 
            420                 425                 430         


Ala Ser Ala Ala Gln Asn Thr Ala Gly Leu Ser Phe Gly Gly Ile Asn 
        435                 440                 445             


Thr Leu Glu Glu Asn Ser Thr Asn Glu Glu 
    450                 455             


<210>  3803
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM160B1__Homo_sapiens__NP_001128523

<400>  3803

Met Phe Ser Lys Phe Thr Ser Ile Leu Gln His Ala Val Glu Ala Leu 
1               5                   10                  15      


Ala Pro Ser Leu Pro Leu Gln Glu Asp Phe Val Tyr His Trp Lys Ala 
            20                  25                  30          


Ile Thr His Tyr Tyr Ile Glu Thr Ser Asp Asp Lys Ala Pro Val Thr 
        35                  40                  45              


Asp Thr Asn Ile Pro Ser His Leu Glu Gln Met Leu Asp Ile Leu Val 
    50                  55                  60                  


Gln Glu Glu Asn Glu Arg Glu Ser Gly Glu Thr Gly Pro Cys Met Glu 
65                  70                  75                  80  


Tyr Leu Leu His His Lys Ile Leu Glu Thr Leu Tyr Thr Leu Gly Lys 
                85                  90                  95      


Ala Asp Cys Pro Pro Gly Met Lys Gln Gln Val Leu Val Phe Tyr Thr 
            100                 105                 110         


Lys Leu Leu Gly Arg Ile Arg Gln Pro Leu Leu Pro His Ile Asn Val 
        115                 120                 125             


His Arg Pro Val Gln Lys Leu Ile Arg Leu Cys Gly Glu Val Leu Ala 
    130                 135                 140                 


Thr Pro Thr Glu Asn Glu Glu Ile Gln Phe Leu Cys Ile Val Cys Ala 
145                 150                 155                 160 


Lys Leu Lys Gln Asp Pro Tyr Leu Val Asn Phe Phe Leu Glu Asn Lys 
                165                 170                 175     


Met Lys Ser Leu Ala Ser Lys Gly Val Pro Asn Val Ile Ser Glu Asp 
            180                 185                 190         


Thr Leu Lys Gly Gln Asp Ser Leu Ser Thr Asp Thr Gly Gln Ser Arg 
        195                 200                 205             


Gln Pro Glu Glu Leu Ser Gly Ala Thr Gly Met Glu Gln Thr Glu Leu 
    210                 215                 220                 


Glu Asp Glu Pro Pro His Gln Met Asp His Leu Ser Thr Ser Leu Asp 
225                 230                 235                 240 


Asn Leu Ser Val Thr Ser Leu Pro Glu Ala Ser Val Val Cys Pro Asn 
                245                 250                 255     


Gln Asp Tyr Asn Leu Val Asn Ser Leu Leu Asn Leu Thr Arg Ser Pro 
            260                 265                 270         


Asp Gly Arg Ile Ala Val Lys Ala Cys Glu Gly Leu Met Leu Leu Val 
        275                 280                 285             


Ser Leu Pro Glu Pro Ala Ala Ala Lys Cys Leu Thr Gln Ser Thr Cys 
    290                 295                 300                 


Leu Cys Glu Leu Leu Thr Asp Arg Leu Ala Ser Leu Tyr Lys Ala Leu 
305                 310                 315                 320 


Pro Gln Ser Val Asp Pro Leu Asp Ile Glu Thr Val Glu Ala Ile Asn 
                325                 330                 335     


Trp Gly Leu Asp Ser Tyr Ser His Lys Glu Asp Ala Ser Ala Phe Pro 
            340                 345                 350         


Gly Lys Arg Ala Leu Ile Ser Phe Leu Ser Trp Phe Asp Tyr Cys Asp 
        355                 360                 365             


Gln Leu Ile Lys Glu Ala Gln Lys Thr Ala Ala Val Ala Leu Ala Lys 
    370                 375                 380                 


Ala Val His Glu Arg Phe Phe Ile Gly Val Met Glu Pro Gln Leu Met 
385                 390                 395                 400 


Gln Thr Ser Glu Met Gly Ile Leu Thr Ser Thr Ala Leu Leu His Arg 
                405                 410                 415     


Ile Val Arg Gln Val Thr Ser Asp Val Leu Leu Gln Glu Met Val Phe 
            420                 425                 430         


Phe Ile Leu Gly Glu Gln Arg Glu Pro Glu Thr Leu Ala Glu Ile Ser 
        435                 440                 445             


Arg His Pro Leu Arg His Arg Leu Ile Glu His Cys Asp His Ile Ser 
    450                 455                 460                 


Asp Glu Ile Ser Ile Met Thr Leu Arg Met Phe Glu His Leu Leu Gln 
465                 470                 475                 480 


Lys Pro Asn Glu His Ile Leu Tyr Asn Leu Val Leu Arg Asn Leu Glu 
                485                 490                 495     


Glu Arg Asn Tyr Thr Glu Tyr Lys Pro Leu Cys Pro Glu Asp Lys Asp 
            500                 505                 510         


Val Val Glu Asn Gly Leu Ile Ala Gly Ala Val Asp Leu Glu Glu Asp 
        515                 520                 525             


Pro Leu Phe Thr Asp Ile Ser Pro Glu Asn Thr Leu Pro Asn Gln Glu 
    530                 535                 540                 


Trp Leu Ser Ser Ser Pro Pro Ala Thr Pro Asp His Pro Lys Asn Asp 
545                 550                 555                 560 


Gly Lys Thr Glu Val His Lys Ile Val Asn Ser Phe Leu Cys Leu Val 
                565                 570                 575     


Pro Asp Asp Ala Lys Ser Ser Tyr His Val Glu Gly Thr Gly Tyr Asp 
            580                 585                 590         


Thr Tyr Leu Arg Asp Ala His Arg Gln Phe Arg Asp Tyr Cys Ala Ile 
        595                 600                 605             


Cys Leu Arg Trp Glu Trp Pro Gly Ser Pro Lys Ala Leu Glu Lys Cys 
    610                 615                 620                 


Asn Leu Glu Ala Ala Phe Phe Glu Gly His Phe Leu Lys Val Leu Phe 
625                 630                 635                 640 


Asp Arg Met Gly Arg Ile Leu Asp Gln Pro Tyr Asp Val Asn Leu Gln 
                645                 650                 655     


Val Thr Ser Val Leu Ser Arg Leu Ser Leu Phe Pro His Pro His Ile 
            660                 665                 670         


His Glu Tyr Leu Leu Asp Pro Tyr Val Asn Leu Ala Pro Gly Cys Arg 
        675                 680                 685             


Ser Leu Phe Ser Val Ile Val Arg Val Val Gly Asp Leu Met Leu Arg 
    690                 695                 700                 


Ile Gln Arg Ile Gln Asp Phe Thr Pro Lys Leu Leu Leu Val Arg Lys 
705                 710                 715                 720 


Arg Leu Leu Gly Leu Glu Pro Glu Gly Pro Met Gln Thr Leu Pro Ser 
                725                 730                 735     


Trp Trp 
        


<210>  3804
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM161A__Homo_sapiens__NP_001188472

<400>  3804

Met Ala Thr Ser His Arg Val Ala Lys Leu Val Ala Ser Ser Leu Gln 
1               5                   10                  15      


Thr Pro Val Asn Pro Ile Thr Gly Ala Arg Val Ala Gln Tyr Glu Arg 
            20                  25                  30          


Glu Asp Pro Leu Lys Ala Leu Ala Ala Ala Glu Ala Ile Leu Glu Asp 
        35                  40                  45              


Glu Glu Glu Glu Lys Val Ala Gln Pro Ala Gly Ala Ser Ala Asp Leu 
    50                  55                  60                  


Asn Thr Ser Phe Ser Gly Val Asp Glu His Ala Pro Ile Ser Tyr Glu 
65                  70                  75                  80  


Asp Phe Val Asn Phe Pro Asp Ile His His Ser Asn Glu Glu Tyr Phe 
                85                  90                  95      


Lys Lys Val Glu Glu Leu Lys Ala Ala His Ile Glu Thr Met Ala Lys 
            100                 105                 110         


Leu Glu Lys Met Tyr Gln Asp Lys Leu His Leu Lys Glu Val Gln Pro 
        115                 120                 125             


Val Val Ile Arg Glu Asp Ser Leu Ser Asp Ser Ser Arg Ser Val Ser 
    130                 135                 140                 


Glu Lys Asn Ser Tyr His Pro Val Ser Leu Met Thr Ser Phe Ser Glu 
145                 150                 155                 160 


Pro Asp Leu Gly Gln Ser Ser Ser Leu Tyr Val Ser Ser Ser Glu Glu 
                165                 170                 175     


Glu Leu Pro Asn Leu Glu Lys Glu Tyr Pro Arg Lys Asn Arg Met Met 
            180                 185                 190         


Thr Tyr Ala Lys Glu Leu Ile Asn Asn Met Trp Thr Asp Phe Cys Val 
        195                 200                 205             


Glu Asp Tyr Ile Arg Cys Lys Asp Thr Gly Phe His Ala Ala Glu Lys 
    210                 215                 220                 


Arg Arg Lys Lys Arg Lys Glu Trp Val Pro Thr Ile Thr Val Pro Glu 
225                 230                 235                 240 


Pro Phe Gln Met Met Ile Arg Glu Gln Lys Lys Lys Glu Glu Ser Met 
                245                 250                 255     


Lys Ser Lys Ser Asp Ile Glu Met Val His Lys Ala Leu Lys Lys Gln 
            260                 265                 270         


Glu Glu Asp Pro Glu Tyr Lys Lys Lys Phe Arg Ala Asn Pro Val Pro 
        275                 280                 285             


Ala Ser Val Phe Leu Pro Leu Tyr His Asp Leu Val Lys Gln Lys Glu 
    290                 295                 300                 


Glu Arg Arg Arg Ser Leu Lys Glu Lys Ser Lys Glu Ala Leu Leu Ala 
305                 310                 315                 320 


Ser Gln Lys Pro Phe Lys Phe Ile Ala Arg Glu Glu Gln Lys Arg Ala 
                325                 330                 335     


Ala Arg Glu Lys Gln Leu Arg Asp Phe Leu Lys Tyr Lys Lys Lys Thr 
            340                 345                 350         


Asn Arg Phe Lys Ala Arg Pro Ile Pro Arg Ser Thr Tyr Gly Ser Thr 
        355                 360                 365             


Thr Asn Asp Lys Leu Lys Glu Glu Glu Leu Tyr Arg Asn Leu Arg Thr 
    370                 375                 380                 


Gln Leu Arg Ala Gln Glu His Leu Gln Asn Ser Ser Pro Leu Pro Cys 
385                 390                 395                 400 


Arg Ser Ala Cys Gly Cys Arg Asn Pro Arg Cys Pro Glu Gln Ala Val 
                405                 410                 415     


Lys Leu Lys Cys Lys His Lys Val Arg Cys Pro Thr Pro Asp Phe Glu 
            420                 425                 430         


Asp Leu Pro Glu Arg Tyr Gln Lys His Leu Ser Glu His Lys Ser Pro 
        435                 440                 445             


Lys Leu Leu Thr Val Cys Lys Pro Phe Asp Leu His Ala Ser Pro His 
    450                 455                 460                 


Ala Ser Ile Lys Arg Glu Lys Ile Leu Ala Asp Ile Glu Ala Asp Glu 
465                 470                 475                 480 


Glu Asn Leu Lys Glu Thr Arg Trp Pro Tyr Leu Ser Pro Arg Arg Lys 
                485                 490                 495     


Ser Pro Val Arg Cys Ala Gly Val Asn Pro Val Pro Cys Asn Cys Asn 
            500                 505                 510         


Pro Pro Val Pro Thr Val Ser Ser Arg Gly Arg Glu Gln Ala Val Arg 
        515                 520                 525             


Arg Ser Leu Glu Glu Lys Lys Met Leu Glu Glu Glu Arg Asn Arg Ile 
    530                 535                 540                 


Leu Thr Lys Gln Lys Gln Arg Met Lys Glu Leu Gln Lys Leu Leu Thr 
545                 550                 555                 560 


Thr Arg Ala Lys Ala Tyr Asp Ser His Gln Ser Leu Ala Gln Ile Ser 
                565                 570                 575     


Lys Ser Arg Val Lys Cys Leu Arg Lys Ser Glu Lys Glu Arg Met Arg 
            580                 585                 590         


Glu Tyr Gln Arg Glu Leu Glu Glu Arg Glu Glu Lys Leu Lys Lys Arg 
        595                 600                 605             


Pro Leu Leu Phe Glu Arg Val Ala Gln Lys Asn Ala Arg Met Ala Ala 
    610                 615                 620                 


Glu Lys His Tyr Ser Asn Thr Leu Lys Ala Leu Gly Ile Ser Asp Glu 
625                 630                 635                 640 


Phe Val Ser Lys Lys Gly Gln Ser Gly Lys Val Leu Glu Tyr Phe Asn 
                645                 650                 655     


Asn Gln Glu Thr Lys Ser Val Thr Glu Asp Lys Glu Ser Phe Asn Glu 
            660                 665                 670         


Glu Glu Lys Ile Glu Glu Arg Glu Asn Gly Glu Glu Asn Tyr Phe Ile 
        675                 680                 685             


Asp Thr Asn Ser Gln Asp Ser Tyr Lys Glu Lys Asp Glu Ala Asn Glu 
    690                 695                 700                 


Glu Ser Glu Glu Glu Lys Ser Val Glu Glu Ser His 
705                 710                 715     


<210>  3805
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM163A__Homo_sapiens__NP_775780

<400>  3805

Met Thr Ala Gly Thr Val Val Ile Thr Gly Gly Ile Leu Ala Thr Val 
1               5                   10                  15      


Ile Leu Leu Cys Ile Ile Ala Val Leu Cys Tyr Cys Arg Leu Gln Tyr 
            20                  25                  30          


Tyr Cys Cys Lys Lys Ser Gly Thr Glu Val Ala Asp Glu Glu Glu Glu 
        35                  40                  45              


Arg Glu His Asp Leu Pro Thr His Pro Arg Gly Pro Thr Cys Asn Ala 
    50                  55                  60                  


Cys Ser Ser Gln Ala Leu Asp Gly Arg Gly Ser Leu Ala Pro Leu Thr 
65                  70                  75                  80  


Ser Glu Pro Cys Ser Gln Pro Cys Gly Val Ala Ala Ser His Cys Thr 
                85                  90                  95      


Thr Cys Ser Pro Tyr Ser Ser Pro Phe Tyr Ile Arg Thr Ala Asp Met 
            100                 105                 110         


Val Pro Asn Gly Gly Gly Gly Glu Arg Leu Ser Phe Ala Pro Thr Tyr 
        115                 120                 125             


Tyr Lys Glu Gly Gly Pro Pro Ser Leu Lys Leu Ala Ala Pro Gln Ser 
    130                 135                 140                 


Tyr Pro Val Thr Trp Pro Gly Ser Gly Arg Glu Ala Phe Thr Asn Pro 
145                 150                 155                 160 


Arg Ala Ile Ser Thr Asp Val 
                165         


<210>  3806
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM163B__Homo_sapiens__NP_001073984

<400>  3806

Met Thr Ala Gly Thr Val Val Ile Thr Gly Gly Ile Leu Ala Thr Val 
1               5                   10                  15      


Ile Leu Leu Cys Ile Ile Ala Val Leu Cys Tyr Cys Arg Leu Gln Tyr 
            20                  25                  30          


Tyr Cys Cys Lys Lys Asp Glu Ser Glu Glu Asp Glu Glu Glu Pro Asp 
        35                  40                  45              


Phe Ala Val His Ser His Leu Pro Pro Leu His Ser Asn Arg Asn Leu 
    50                  55                  60                  


Val Leu Thr Asn Gly Pro Ala Leu Tyr Pro Thr Ala Ser Thr Ser Phe 
65                  70                  75                  80  


Ser Gln Lys Ser Pro Gln Ala Arg Ala Leu Cys Arg Ser Cys Ser His 
                85                  90                  95      


Cys Glu Pro Pro Thr Phe Phe Leu Gln Glu Pro Pro Glu Glu Glu Glu 
            100                 105                 110         


Asp Val Leu Asn Gly Gly Glu Arg Val Leu Tyr Lys Ser Val Ser Gln 
        115                 120                 125             


Glu Asp Val Glu Leu Pro Pro Gly Gly Phe Gly Gly Leu Gln Ala Leu 
    130                 135                 140                 


Asn Pro Asn Arg Leu Ser Ala Met Arg Glu Ala Phe Ala Arg Ser Arg 
145                 150                 155                 160 


Ser Ile Ser Thr Asp Val 
                165     


<210>  3807
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM167A__Homo_sapiens__NP_444509

<400>  3807

Met Ser Val Pro Gln Ile His Val Glu Glu Val Gly Ala Glu Glu Gly 
1               5                   10                  15      


Ala Gly Ala Ala Ala Pro Pro Asp Asp His Leu Arg Ser Leu Lys Ala 
            20                  25                  30          


Leu Thr Glu Lys Leu Arg Leu Glu Thr Arg Arg Pro Ser Tyr Leu Glu 
        35                  40                  45              


Trp Gln Ala Arg Leu Glu Glu His Thr Trp Pro Phe Pro Arg Pro Ala 
    50                  55                  60                  


Ala Glu Pro Gln Ala Ser Leu Glu Glu Gly Glu Arg Gly Gly Gln Glu 
65                  70                  75                  80  


Pro Leu Leu Pro Leu Arg Glu Ala Gly Gln His Pro Pro Ser Ala Arg 
                85                  90                  95      


Ser Ala Ser Gln Gly Ala Arg Pro Leu Ser Thr Gly Lys Leu Glu Gly 
            100                 105                 110         


Phe Gln Ser Ile Asp Glu Ala Ile Ala Trp Leu Arg Lys Glu Leu Thr 
        115                 120                 125             


Glu Met Arg Leu Gln Asp Gln Gln Leu Ala Arg Gln Leu Met Arg Leu 
    130                 135                 140                 


Arg Gly Asp Ile Asn Lys Leu Lys Ile Glu His Thr Cys Arg Leu His 
145                 150                 155                 160 


Arg Arg Met Leu Asn Asp Ala Thr Tyr Glu Leu Glu Glu Arg Asp Glu 
                165                 170                 175     


Leu Ala Asp Leu Phe Cys Asp Ser Pro Leu Ala Ser Ser Phe Ser Leu 
            180                 185                 190         


Ser Thr Pro Leu Lys Leu Ile Gly Val Thr Lys Met Asn Ile Asn Ser 
        195                 200                 205             


Arg Arg Phe Ser Leu Cys 
    210                 


<210>  3808
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM168A__Homo_sapiens__NP_001272979

<400>  3808

Met Asn Pro Val Tyr Ser Pro Val Gln Pro Gly Ala Pro Tyr Gly Asn 
1               5                   10                  15      


Pro Lys Asn Met Ala Tyr Thr Gly Tyr Pro Thr Ala Tyr Pro Ala Ala 
            20                  25                  30          


Ala Pro Ala Tyr Asn Pro Ser Leu Tyr Pro Thr Asn Ser Pro Ser Tyr 
        35                  40                  45              


Ala Pro Glu Phe Gln Phe Leu His Ser Ala Tyr Ala Thr Leu Leu Met 
    50                  55                  60                  


Lys Gln Ala Trp Pro Gln Asn Ser Ser Ser Cys Gly Thr Glu Gly Thr 
65                  70                  75                  80  


Phe His Leu Pro Val Asp Thr Gly Thr Glu Asn Arg Thr Tyr Gln Ala 
                85                  90                  95      


Ser Ser Ala Ala Phe Arg Tyr Thr Ala Gly Thr Pro Tyr Lys Val Pro 
            100                 105                 110         


Pro Thr Gln Ser Asn Thr Ala Pro Pro Pro Tyr Ser Pro Ser Pro Asn 
        115                 120                 125             


Pro Tyr Gln Thr Ala Met Tyr Pro Ile Arg Ser Ala Tyr Pro Gln Gln 
    130                 135                 140                 


Asn Leu Tyr Ala Gln Gly Ala Tyr Tyr Thr Gln Pro Val Tyr Ala Ala 
145                 150                 155                 160 


Gln Pro His Val Ile His His Thr Thr Val Val Gln Pro Asn Ser Ile 
                165                 170                 175     


Pro Ser Ala Ile Tyr Pro Ala Pro Val Ala Ala Pro Arg Thr Asn Gly 
            180                 185                 190         


Val Ala Met Gly Met Val Ala Gly Thr Thr Met Ala Met Ser Ala Gly 
        195                 200                 205             


Thr Leu Leu Thr Thr Pro Gln His Thr Ala Ile Gly Ala His Pro Val 
    210                 215                 220                 


Ser Met Pro Thr Tyr Arg Ala Gln Gly Thr Pro Ala Tyr Ser Tyr Val 
225                 230                 235                 240 


Pro Pro His Trp 
                


<210>  3809
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM168B__Homo_sapiens__NP_001009993

<400>  3809

Met Asn Pro Val Tyr Ser Pro Gly Ser Ser Gly Val Pro Tyr Ala Asn 
1               5                   10                  15      


Ala Lys Gly Ile Gly Tyr Pro Ala Gly Phe Pro Met Gly Tyr Ala Ala 
            20                  25                  30          


Ala Ala Pro Ala Tyr Ser Pro Asn Met Tyr Pro Gly Ala Asn Pro Thr 
        35                  40                  45              


Phe Gln Thr Gly Tyr Thr Pro Gly Thr Pro Tyr Lys Val Ser Cys Ser 
    50                  55                  60                  


Pro Thr Ser Gly Ala Val Pro Pro Tyr Ser Ser Ser Pro Asn Pro Tyr 
65                  70                  75                  80  


Gln Thr Ala Val Tyr Pro Val Arg Ser Ala Tyr Pro Gln Gln Ser Pro 
                85                  90                  95      


Tyr Ala Gln Gln Gly Thr Tyr Tyr Thr Gln Pro Leu Tyr Ala Ala Pro 
            100                 105                 110         


Pro His Val Ile His His Thr Thr Val Val Gln Pro Asn Gly Met Pro 
        115                 120                 125             


Ala Thr Val Tyr Pro Ala Pro Ile Pro Pro Pro Arg Gly Asn Gly Val 
    130                 135                 140                 


Thr Met Gly Met Val Ala Gly Thr Thr Met Ala Met Ser Ala Gly Thr 
145                 150                 155                 160 


Leu Leu Thr Ala His Ser Pro Thr Pro Val Ala Pro His Pro Val Thr 
                165                 170                 175     


Val Pro Thr Tyr Arg Ala Pro Gly Thr Pro Thr Tyr Ser Tyr Val Pro 
            180                 185                 190         


Pro Gln Trp 
        195 


<210>  3810
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM169B__Homo_sapiens__NP_872368

<400>  3810

Met Lys Val Gln Ser Phe Gly Glu Arg Val Val Leu Phe Ile Leu Asn 
1               5                   10                  15      


Ala Ile Ile Phe Gly Arg Leu Glu Arg Asn Leu Asp Asp Asp Asp Met 
            20                  25                  30          


Phe Phe Leu Pro His Ser Val Lys Glu Gln Ala Lys Ile Leu Trp Arg 
        35                  40                  45              


Arg Gly Ala Ala Val Gly Phe Tyr Thr Thr Lys Met Lys Gly Arg Leu 
    50                  55                  60                  


Cys Gly Asp Gly Thr Gly Ala Cys Tyr Leu Leu Pro Val Phe Asp Thr 
65                  70                  75                  80  


Val Phe Ile Arg Arg Lys His Trp His Arg Gly Leu Gly Thr Ala Met 
                85                  90                  95      


Leu Arg Asp Phe Cys Glu Thr Phe Pro Glu Asp Glu Ala Leu Gly Val 
            100                 105                 110         


Ser Cys Ser Met Ser Pro Ala Met Tyr Gln Ala His Pro Gly Asn Ser 
        115                 120                 125             


Glu Asp Val Ser Arg His Ala Arg Thr Ser Gln Asn Asp Arg Pro Arg 
    130                 135                 140                 


Gln Pro Ala Pro Gly Asp Gly Ser Lys Glu Arg Met Cys Gly Glu Glu 
145                 150                 155                 160 


Leu Glu Asp Thr Lys Asp Asp Pro Glu Cys Gly Val Glu Glu Glu Asp 
                165                 170                 175     


Ala Gly Leu Ala Gly Gln Pro Pro Gly Lys Leu Thr Arg Ser Ser Pro 
            180                 185                 190         


<210>  3811
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM170A__Homo_sapiens__NP_001157463

<400>  3811

Met Lys Arg Arg Gln Lys Arg Lys His Leu Glu Asn Glu Glu Ser Gln 
1               5                   10                  15      


Glu Thr Ala Glu Lys Gly Gly Gly Ile Gln Arg Ile His Arg Asp Ser 
            20                  25                  30          


Pro Gln Pro Gln Ser Pro Leu Ala Gln Val Gln Glu Arg Gly Glu Thr 
        35                  40                  45              


Pro Pro Arg Ser Gln His Val Ser Leu Ser Ser Tyr Ser Ser Tyr Lys 
    50                  55                  60                  


Thr Cys Val Ser Ser Leu Cys Val Asn Lys Glu Glu Arg Gly Met Lys 
65                  70                  75                  80  


Ile Tyr Tyr Met Gln Val Gln Met Asn Lys Gly Val Ala Val Ser Trp 
                85                  90                  95      


Glu Thr Glu Glu Thr Leu Glu Ser Leu Glu Lys Gln Pro Arg Met Glu 
            100                 105                 110         


Glu Val Thr Leu Ser Glu Val Val Arg Val Gly Thr Pro Pro Ser Asp 
        115                 120                 125             


Val Ser Thr Arg Asn Leu Leu Ser Asp Ser Glu Pro Ser Gly Glu Glu 
    130                 135                 140                 


Lys Glu His Glu Glu Arg Thr Glu Ser Asp Ser Leu Pro Gly Ser Pro 
145                 150                 155                 160 


Thr Val Glu Asp Thr Pro Arg Ala Lys Thr Pro Asp Trp Leu Val Thr 
                165                 170                 175     


Met Glu Asn Gly Phe Arg Cys Met Ala Cys Cys Arg Val Phe Thr Thr 
            180                 185                 190         


Met Glu Ala Leu Gln Glu His Val Gln Phe Gly Ile Arg Glu Gly Phe 
        195                 200                 205             


Ser Cys His Val Phe His Leu Thr Met Ala Gln Leu Thr Gly Asn Met 
    210                 215                 220                 


Glu Ser Glu Ser Thr Gln Asp Glu Gln Glu Glu Glu Asn Gly Asn Glu 
225                 230                 235                 240 


Lys Glu Glu Glu Glu Lys Pro Glu Ala Lys Glu Glu Glu Gly Gln Pro 
                245                 250                 255     


Thr Glu Glu Asp Leu Gly Leu Arg Arg Ser Trp Ser Gln Cys Pro Gly 
            260                 265                 270         


Cys Val Phe His Ser Pro Lys Asp Arg Asn 
        275                 280         


<210>  3812
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM172A__Homo_sapiens__NP_001156889

<400>  3812

Met Lys Lys Asp Glu Pro Pro Leu Asp Phe Pro Asp Thr Leu Glu Gly 
1               5                   10                  15      


Phe Glu Tyr Ala Phe Asn Glu Lys Gly Gln Leu Arg His Ile Lys Thr 
            20                  25                  30          


Gly Glu Pro Phe Val Phe Asn Tyr Arg Glu Asp Leu His Arg Trp Asn 
        35                  40                  45              


Gln Lys Arg Tyr Glu Ala Leu Gly Glu Ile Ile Thr Lys Tyr Val Tyr 
    50                  55                  60                  


Glu Leu Leu Glu Lys Asp Cys Asn Leu Lys Lys Val Ser Ile Pro Val 
65                  70                  75                  80  


Asp Ala Thr Glu Ser Glu Pro Lys Ser Phe Ile Phe Met Ser Glu Asp 
                85                  90                  95      


Ala Leu Thr Asn Pro Gln Lys Leu Met Val Leu Ile His Gly Ser Gly 
            100                 105                 110         


Val Val Arg Ala Gly Gln Trp Ala Arg Arg Leu Ile Ile Asn Glu Asp 
        115                 120                 125             


Leu Asp Ser Gly Thr Gln Ile Pro Phe Ile Lys Arg Ala Val Ala Glu 
    130                 135                 140                 


Gly Tyr Gly Val Ile Val Leu Asn Pro Asn Glu Asn Tyr Ile Glu Val 
145                 150                 155                 160 


Glu Lys Pro Lys Ile His Val Gln Ser Ser Ser Asp Ser Ser Asp Glu 
                165                 170                 175     


Pro Ala Glu Lys Arg Glu Arg Lys Asp Lys Val Ser Lys Glu Thr Lys 
            180                 185                 190         


Lys Arg Arg Asp Phe Tyr Glu Lys Tyr Arg Asn Pro Gln Arg Glu Lys 
        195                 200                 205             


Glu Met Met Gln Leu Tyr Ile Arg Glu Asn Gly Ser Pro Glu Glu His 
    210                 215                 220                 


Ala Ile Tyr Val Trp Asp His Phe Ile Ala Gln Ala Ala Ala Glu Asn 
225                 230                 235                 240 


Val Phe Phe Val Ala His Ser Tyr Gly Gly Leu Ala Phe Val Glu Leu 
                245                 250                 255     


Met Ile Gln Arg Glu Ala Asp Val Lys Asn Lys Val Thr Ala Val Ala 
            260                 265                 270         


Leu Thr Asp Ser Val His Asn Val Trp His Gln Glu Ala Gly Lys Thr 
        275                 280                 285             


Ile Arg Glu Trp Met Arg Glu Asn Cys Cys Asn Trp Val Ser Ser Ser 
    290                 295                 300                 


Glu Pro Leu Asp Thr Ser Val Glu Ser Met Leu Pro Asp Cys Pro Arg 
305                 310                 315                 320 


Val Ser Ala Gly Thr Asp Arg His Glu Leu Thr Ser Trp Lys Ser Phe 
                325                 330                 335     


Pro Ser Ile Phe Lys Phe Phe Thr Glu Ala Ser Glu Ala Lys Thr Ser 
            340                 345                 350         


Ser Leu Lys Pro Ala Val Thr Arg Arg Ser His Arg Ile Lys His Glu 
        355                 360                 365             


Glu Leu 
    370 


<210>  3813
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM173B__Homo_sapiens__NP_954584

<400>  3813

Met Glu Gly Gly Gly Gly Ile Pro Leu Glu Thr Leu Lys Glu Glu Ser 
1               5                   10                  15      


Gln Ser Arg His Val Leu Pro Ala Ser Phe Glu Val Asn Ser Leu Gln 
            20                  25                  30          


Lys Ser Asn Trp Gly Phe Leu Leu Thr Gly Leu Val Gly Gly Thr Leu 
        35                  40                  45              


Val Ala Val Tyr Ala Val Ala Thr Pro Phe Val Thr Pro Ala Leu Arg 
    50                  55                  60                  


Lys Val Cys Leu Pro Phe Val Pro Ala Thr Thr Lys Gln Ile Glu Asn 
65                  70                  75                  80  


Val Val Lys Met Leu Arg Cys Arg Arg Gly Ser Leu Val Asp Ile Gly 
                85                  90                  95      


Ser Gly Asp Gly Arg Ile Val Ile Ala Ala Ala Lys Lys Gly Phe Thr 
            100                 105                 110         


Ala Val Gly Tyr Glu Leu Asn Pro Trp Leu Val Trp Tyr Ser Arg Tyr 
        115                 120                 125             


Arg Ala Trp Arg Glu Gly Val His Gly Ser Ala Lys Phe Tyr Ile Ser 
    130                 135                 140                 


Asp Leu Trp Lys Val Thr Phe Ser Gln Tyr Ser Asn Val Val Ile Phe 
145                 150                 155                 160 


Gly Val Pro Gln Met Met Leu Gln Leu Glu Lys Lys Leu Glu Arg Glu 
                165                 170                 175     


Leu Glu Asp Asp Ala Arg Val Ile Ala Cys Arg Phe Pro Phe Pro His 
            180                 185                 190         


Trp Thr Pro Asp His Val Thr Gly Glu Gly Ile Asp Thr Val Trp Ala 
        195                 200                 205             


Tyr Asp Ala Ser Thr Phe Arg Gly Arg Glu Lys Arg Pro Cys Thr Ser 
    210                 215                 220                 


Met His Phe Gln Leu Pro Ile Gln Ala 
225                 230             


<210>  3814
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM174A__Homo_sapiens__NP_940909

<400>  3814

Met Lys Ala Ser Gln Cys Cys Cys Cys Leu Ser His Leu Leu Ala Ser 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Leu Pro Glu Leu Ser Gly Pro Leu Ala Val 
            20                  25                  30          


Leu Leu Gln Ala Ala Glu Ala Ala Pro Gly Leu Gly Pro Pro Asp Pro 
        35                  40                  45              


Arg Pro Arg Thr Leu Pro Pro Leu Pro Pro Gly Pro Thr Pro Ala Gln 
    50                  55                  60                  


Gln Pro Gly Arg Gly Leu Ala Glu Ala Ala Gly Pro Arg Gly Ser Glu 
65                  70                  75                  80  


Gly Gly Asn Gly Ser Asn Pro Val Ala Gly Leu Glu Thr Asp Asp His 
                85                  90                  95      


Gly Gly Lys Ala Gly Glu Gly Ser Val Gly Gly Gly Leu Ala Val Ser 
            100                 105                 110         


Pro Asn Pro Gly Asp Lys Pro Met Thr Gln Arg Ala Leu Thr Val Leu 
        115                 120                 125             


Met Val Val Ser Gly Ala Val Leu Val Tyr Phe Val Val Arg Thr Val 
    130                 135                 140                 


Arg Met Arg Arg Arg Asn Arg Lys Thr Arg Arg Tyr Gly Val Leu Asp 
145                 150                 155                 160 


Thr Asn Ile Glu Asn Met Glu Leu Thr Pro Leu Glu Gln Asp Asp Glu 
                165                 170                 175     


Asp Asp Asp Asn Thr Leu Phe Asp Ala Asn His Pro Arg Arg 
            180                 185                 190 


<210>  3815
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM175A__Homo_sapiens__NP_620775

<400>  3815

Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Glu Gly Phe 
            20                  25                  30          


Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn Ser Ile Thr Asp Ser 
        35                  40                  45              


Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile Asp Ile Gln Lys Tyr 
    50                  55                  60                  


Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn Ser Ser Gly Glu Val 
65                  70                  75                  80  


Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn Val Lys Lys Asn Val 
                85                  90                  95      


Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp Gln Ile Met Thr Phe 
            100                 105                 110         


Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu His Phe Ser Asn Gln 
        115                 120                 125             


Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile Ile Thr Glu Ser Cys 
    130                 135                 140                 


Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys Pro Gln Lys Gly Leu 
145                 150                 155                 160 


Phe His Arg Val Pro Leu Val Val Ala Asn Leu Gly Met Ser Glu Gln 
                165                 170                 175     


Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met Ser Thr Gly Phe Ser 
            180                 185                 190         


Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe Glu Glu Asp Gly Ser 
        195                 200                 205             


Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr Ala Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp Ser Glu Gln Ala Val 
225                 230                 235                 240 


Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys Arg Glu Ile Glu Lys 
                245                 250                 255     


Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu Lys Asn Ile Gln Lys 
            260                 265                 270         


Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala Leu Arg Thr Phe Phe 
        275                 280                 285             


Pro Asn Ser Glu Phe Leu His Ser Cys Val Met Ser Leu Lys Asn Arg 
    290                 295                 300                 


His Val Ser Lys Ser Ser Cys Asn Tyr Asn His His Leu Asp Val Val 
305                 310                 315                 320 


Asp Asn Leu Thr Leu Met Val Glu His Thr Asp Ile Pro Glu Ala Ser 
                325                 330                 335     


Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys Ala Leu Asp Leu Asp 
            340                 345                 350         


Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu Asp Thr Gln Asp Lys 
        355                 360                 365             


Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln Asp Lys Ala Ser Lys 
    370                 375                 380                 


Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu Lys Met Lys Gly Phe 
385                 390                 395                 400 


Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
                405                 


<210>  3816
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM175B__Homo_sapiens__NP_115558

<400>  3816

Met Ala Ala Ser Ile Ser Gly Tyr Thr Phe Ser Ala Val Cys Phe His 
1               5                   10                  15      


Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe Leu Leu Gly Glu Val 
            20                  25                  30          


Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser Gln Ile Ser Asn Thr 
        35                  40                  45              


Glu Phe Leu Gln Val Ile Glu Ile His Asn His Gln Pro Cys Ser Lys 
    50                  55                  60                  


Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val Asn Glu Glu Ser Leu 
65                  70                  75                  80  


Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val Ile Gly Trp Tyr Arg 
                85                  90                  95      


Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr Arg Glu Gln Val Leu 
            100                 105                 110         


His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro Asp Leu Val Phe Leu 
        115                 120                 125             


Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser Thr His Ala Leu Glu 
    130                 135                 140                 


Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn Gln Arg Ile Ser Leu 
145                 150                 155                 160 


Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln Glu Tyr Lys Val Ser 
                165                 170                 175     


Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys Val Ile Lys Glu His 
            180                 185                 190         


Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met Lys Asp Ile Arg Ala 
        195                 200                 205             


Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys Val Gln Ala Val Cys 
    210                 215                 220                 


Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu Ser Cys Gln Ala Glu 
225                 230                 235                 240 


Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg Lys Asn Glu Lys Glu 
                245                 250                 255     


Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser Arg Gln Met Pro Ser 
            260                 265                 270         


Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met Pro Ser Ser Gly Phe 
        275                 280                 285             


Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala Glu Ala Ser Asp Pro 
    290                 295                 300                 


Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn Gln Glu Ser Thr Leu 
305                 310                 315                 320 


Ser His Ser Arg Met Glu Arg Ser Val Phe Met Pro Arg Pro Gln Ala 
                325                 330                 335     


Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala Gly Leu Lys Tyr Pro 
            340                 345                 350         


Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg Ala Ala Gly Asp Ser 
        355                 360                 365             


Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn Leu Ile Asp Pro Thr 
    370                 375                 380                 


Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys Asp Ser Arg Pro Met 
385                 390                 395                 400 


Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln Thr Ser Gln Ile 
                405                 410                 415 


<210>  3817
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM177A1__Homo_sapiens__NP_001072987

<400>  3817

Met Asp Gln Glu Pro Val Gly Gly Val Glu Arg Gly Glu Ala Val Ala 
1               5                   10                  15      


Ala Ser Gly Ala Ala Ala Ala Ala Ala Phe Gly Glu Ser Ala Gly Gln 
            20                  25                  30          


Met Ser Asn Glu Arg Gly Phe Glu Asn Val Glu Leu Gly Val Ile Gly 
        35                  40                  45              


Lys Lys Lys Lys Val Pro Arg Arg Val Ile His Phe Val Ser Gly Glu 
    50                  55                  60                  


Thr Met Glu Glu Tyr Ser Thr Asp Glu Asp Glu Val Asp Gly Leu Glu 
65                  70                  75                  80  


Lys Lys Asp Val Leu Pro Thr Val Asp Pro Thr Lys Leu Thr Trp Gly 
                85                  90                  95      


Pro Tyr Leu Trp Phe Tyr Met Leu Arg Ala Ala Thr Ser Thr Leu Ser 
            100                 105                 110         


Val Cys Asp Phe Leu Gly Glu Lys Ile Ala Ser Val Leu Gly Ile Ser 
        115                 120                 125             


Thr Pro Lys Tyr Gln Tyr Ala Ile Asp Glu Tyr Tyr Arg Met Lys Lys 
    130                 135                 140                 


Glu Glu Glu Glu Glu Glu Glu Glu Asn Arg Met Ser Glu Glu Ala Glu 
145                 150                 155                 160 


Lys Gln Tyr Gln Gln Asn Lys Leu Gln Thr Asp Ser Ile Val Gln Thr 
                165                 170                 175     


Asp Gln Pro Glu Thr Val Ile Ser Ser Ser Phe Val Asn Val Asn Phe 
            180                 185                 190         


Glu Met Glu Gly Asp Ser Glu Val Ile Met Glu Ser Lys Gln Asn Pro 
        195                 200                 205             


Val Ser Val Pro Pro 
    210             


<210>  3818
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM177B__Homo_sapiens__NP_997351

<400>  3818

Met Glu Ile Asp Gly Phe Gln Gln Leu Asp Leu Glu Lys Ser Val Pro 
1               5                   10                  15      


Ser Lys Lys Thr Thr Pro Lys Arg Ile Ile His Phe Val Asp Gly Asp 
            20                  25                  30          


Ile Met Glu Glu Tyr Ser Thr Glu Glu Glu Glu Glu Glu Glu Lys Glu 
        35                  40                  45              


Glu Gln Ser Thr Asn Ser Thr Leu Asp Pro Ser Lys Leu Ser Trp Gly 
    50                  55                  60                  


Pro Tyr Leu Arg Phe Trp Ala Gly Arg Ile Ala Ser Thr Ser Phe Ser 
65                  70                  75                  80  


Thr Cys Glu Phe Leu Gly Gly Arg Phe Ala Val Phe Phe Gly Leu Thr 
                85                  90                  95      


Gln Pro Lys Tyr Gln Tyr Val Leu Asn Glu Phe Tyr Arg Ile Gln Asn 
            100                 105                 110         


Lys Lys Ser Asp Asn Lys Ser Glu Arg Arg Gly Ser Lys Ala Gln Ala 
        115                 120                 125             


Ala Glu Val Pro Asn Glu Lys Cys His Leu Glu Ala Gly Val Gln Glu 
    130                 135                 140                 


Tyr Gly Thr Ile Gln Gln Asp Val Thr Glu Ala Ile Pro Gln 
145                 150                 155             


<210>  3819
<211>  1186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM178A__Homo_sapiens__NP_001129595

<400>  3819

Met Thr Arg Arg Cys Met Pro Ala Arg Pro Gly Phe Pro Ser Ser Pro 
1               5                   10                  15      


Ala Pro Gly Ser Ser Pro Pro Arg Cys His Leu Arg Pro Gly Ser Thr 
            20                  25                  30          


Ala His Ala Ala Ala Gly Lys Arg Thr Glu Ser Pro Gly Asp Arg Lys 
        35                  40                  45              


Gln Ser Ile Ile Asp Phe Phe Lys Pro Ala Ser Lys Gln Asp Arg His 
    50                  55                  60                  


Met Leu Asp Ser Pro Gln Lys Ser Asn Ile Lys Tyr Gly Gly Ser Arg 
65                  70                  75                  80  


Leu Ser Ile Thr Gly Thr Glu Gln Phe Glu Arg Lys Leu Ser Ser Pro 
                85                  90                  95      


Lys Glu Ser Lys Pro Lys Arg Val Pro Pro Glu Lys Ser Pro Ile Ile 
            100                 105                 110         


Glu Ala Phe Met Lys Gly Val Lys Glu His His Glu Asp His Gly Ile 
        115                 120                 125             


His Glu Ser Arg Arg Pro Cys Leu Ser Leu Ala Ser Lys Tyr Leu Ala 
    130                 135                 140                 


Lys Gly Thr Asn Ile Tyr Val Pro Ser Ser Tyr His Leu Pro Lys Glu 
145                 150                 155                 160 


Met Lys Ser Leu Lys Lys Lys His Arg Ser Pro Glu Arg Arg Lys Ser 
                165                 170                 175     


Leu Phe Ile His Glu Asn Asn Glu Lys Asn Asp Arg Asp Arg Gly Lys 
            180                 185                 190         


Thr Asn Ala Asp Ser Lys Lys Gln Thr Thr Val Ala Glu Ala Asp Ile 
        195                 200                 205             


Phe Asn Asn Ser Ser Arg Ser Leu Ser Ser Arg Ser Ser Leu Ser Arg 
    210                 215                 220                 


His His Pro Glu Glu Ser Pro Leu Gly Ala Lys Phe Gln Leu Ser Leu 
225                 230                 235                 240 


Ala Ser Tyr Cys Arg Glu Arg Glu Leu Lys Arg Leu Arg Lys Glu Gln 
                245                 250                 255     


Met Glu Gln Arg Ile Asn Ser Glu Asn Ser Phe Ser Glu Ala Ser Ser 
            260                 265                 270         


Leu Ser Leu Lys Ser Ser Ile Glu Arg Lys Tyr Lys Pro Arg Gln Glu 
        275                 280                 285             


Gln Arg Lys Gln Asn Asp Ile Ile Pro Gly Lys Asn Asn Leu Ser Asn 
    290                 295                 300                 


Val Glu Asn Gly His Leu Ser Arg Lys Arg Ser Ser Ser Asp Ser Trp 
305                 310                 315                 320 


Glu Pro Thr Ser Ala Gly Ser Lys Gln Asn Lys Phe Pro Glu Lys Arg 
                325                 330                 335     


Lys Arg Asn Ser Val Asp Ser Asp Leu Lys Ser Thr Arg Glu Ser Met 
            340                 345                 350         


Ile Pro Lys Ala Arg Glu Ser Phe Leu Glu Lys Arg Pro Asp Gly Pro 
        355                 360                 365             


His Gln Lys Glu Lys Phe Ile Lys His Ile Ala Leu Lys Thr Pro Gly 
    370                 375                 380                 


Asp Val Leu Arg Leu Glu Asp Ile Ser Lys Glu Pro Ser Asp Glu Thr 
385                 390                 395                 400 


Asp Gly Ser Ser Ala Gly Leu Ala Pro Ser Asn Ser Gly Asn Ser Gly 
                405                 410                 415     


His His Ser Thr Arg Asn Ser Asp Gln Ile Gln Val Ala Gly Thr Lys 
            420                 425                 430         


Glu Thr Lys Met Gln Lys Pro His Leu Pro Leu Ser Gln Glu Lys Ser 
        435                 440                 445             


Ala Ile Lys Lys Ala Ser Asn Leu Gln Lys Asn Lys Thr Ala Ser Ser 
    450                 455                 460                 


Thr Thr Lys Glu Lys Glu Thr Lys Leu Pro Leu Leu Ser Arg Val Pro 
465                 470                 475                 480 


Ser Ala Gly Ser Ser Leu Val Pro Leu Asn Ala Lys Asn Cys Ala Leu 
                485                 490                 495     


Pro Val Ser Lys Lys Asp Lys Glu Arg Ser Ser Ser Lys Glu Cys Ser 
            500                 505                 510         


Gly His Ser Thr Glu Ser Thr Lys His Lys Glu His Lys Ala Lys Thr 
        515                 520                 525             


Asn Lys Ala Asp Ser Asn Val Ser Ser Gly Lys Ile Ser Gly Gly Pro 
    530                 535                 540                 


Leu Arg Ser Glu Tyr Gly Thr Pro Thr Lys Ser Pro Pro Ala Ala Leu 
545                 550                 555                 560 


Glu Val Val Pro Cys Ile Pro Ser Pro Ala Ala Pro Ser Asp Lys Ala 
                565                 570                 575     


Pro Ser Glu Gly Glu Ser Ser Gly Asn Ser Asn Ala Gly Ser Ser Ala 
            580                 585                 590         


Leu Lys Arg Lys Leu Arg Gly Asp Phe Asp Ser Asp Glu Glu Ser Leu 
        595                 600                 605             


Gly Tyr Asn Leu Asp Ser Asp Glu Glu Glu Glu Thr Leu Lys Ser Leu 
    610                 615                 620                 


Glu Glu Ile Met Ala Leu Asn Phe Asn Gln Thr Pro Ala Ala Thr Gly 
625                 630                 635                 640 


Lys Pro Pro Ala Leu Ser Lys Gly Leu Arg Ser Gln Ser Ser Asp Tyr 
                645                 650                 655     


Thr Gly His Val His Pro Gly Thr Tyr Thr Asn Thr Leu Glu Arg Leu 
            660                 665                 670         


Val Lys Glu Met Glu Asp Thr Gln Arg Leu Asp Glu Leu Gln Lys Gln 
        675                 680                 685             


Leu Gln Glu Asp Ile Arg Gln Gly Arg Gly Ile Lys Ser Pro Ile Arg 
    690                 695                 700                 


Ile Gly Glu Glu Asp Ser Thr Asp Asp Glu Asp Gly Leu Leu Glu Glu 
705                 710                 715                 720 


His Lys Glu Phe Leu Lys Lys Phe Ser Val Thr Ile Asp Ala Ile Pro 
                725                 730                 735     


Asp His His Pro Gly Glu Glu Ile Phe Asn Phe Leu Asn Ser Gly Lys 
            740                 745                 750         


Ile Phe Asn Gln Tyr Thr Leu Asp Leu Arg Asp Ser Gly Phe Ile Gly 
        755                 760                 765             


Gln Ser Ala Val Glu Lys Leu Ile Leu Lys Ser Gly Lys Thr Asp Gln 
    770                 775                 780                 


Ile Phe Leu Thr Thr Gln Gly Phe Leu Thr Ser Ala Tyr His Tyr Val 
785                 790                 795                 800 


Gln Cys Pro Val Pro Val Leu Lys Trp Leu Phe Arg Met Met Ser Val 
                805                 810                 815     


His Thr Asp Cys Ile Val Ser Val Gln Ile Leu Ser Thr Leu Met Glu 
            820                 825                 830         


Ile Thr Ile Arg Asn Asp Thr Phe Ser Asp Ser Pro Val Trp Pro Trp 
        835                 840                 845             


Ile Pro Ser Leu Ser Asp Val Ala Ala Val Phe Phe Asn Met Gly Ile 
    850                 855                 860                 


Asp Phe Arg Ser Leu Phe Pro Leu Glu Asn Leu Gln Pro Asp Phe Asn 
865                 870                 875                 880 


Glu Asp Tyr Leu Val Ser Glu Thr Gln Thr Thr Ser Arg Gly Lys Glu 
                885                 890                 895     


Ser Glu Asp Ser Ser Tyr Lys Pro Ile Phe Ser Thr Leu Pro Glu Thr 
            900                 905                 910         


Asn Ile Leu Asn Val Val Lys Phe Leu Gly Leu Cys Thr Ser Ile His 
        915                 920                 925             


Pro Glu Gly Tyr Gln Asp Arg Glu Ile Met Leu Leu Ile Leu Met Leu 
    930                 935                 940                 


Phe Lys Met Ser Leu Glu Lys Gln Leu Lys Gln Ile Pro Leu Val Asp 
945                 950                 955                 960 


Phe Gln Ser Leu Leu Ile Asn Leu Met Lys Asn Ile Arg Asp Trp Asn 
                965                 970                 975     


Thr Lys Val Pro Glu Leu Cys Leu Gly Ile Asn Glu Leu Ser Ser His 
            980                 985                 990         


Pro His Asn Leu Leu Trp Leu Val  Gln Leu Val Pro Asn  Trp Thr Ser 
        995                 1000                 1005             


Arg Gly  Arg Gln Leu Arg Gln  Cys Leu Ser Leu Val  Ile Ile Ser 
    1010                 1015                 1020             


Lys Leu  Leu Asp Glu Lys His  Glu Asp Val Pro Asn  Ala Ser Asn 
    1025                 1030                 1035             


Leu Gln  Val Ser Val Leu His  Arg Tyr Leu Val Gln  Met Lys Pro 
    1040                 1045                 1050             


Ser Asp  Leu Leu Lys Lys Met  Val Leu Lys Lys Lys  Ala Glu Gln 
    1055                 1060                 1065             


Pro Asp  Gly Ile Ile Asp Asp  Ser Leu His Leu Glu  Leu Glu Lys 
    1070                 1075                 1080             


Gln Ala  Tyr Tyr Leu Thr Tyr  Ile Leu Leu His Leu  Val Gly Glu 
    1085                 1090                 1095             


Val Ser  Cys Ser His Ser Phe  Ser Ser Gly Gln Arg  Lys His Phe 
    1100                 1105                 1110             


Val Leu  Leu Cys Gly Ala Leu  Glu Lys His Val Lys  Cys Asp Ile 
    1115                 1120                 1125             


Arg Glu  Asp Ala Arg Leu Phe  Tyr Arg Thr Lys Val  Lys Asp Leu 
    1130                 1135                 1140             


Val Ala  Arg Ile His Gly Lys  Trp Gln Glu Ile Ile  Gln Asn Cys 
    1145                 1150                 1155             


Arg Pro  Thr Gln Val Ser Phe  Cys Tyr Thr Ile Ser  Cys Ile Leu 
    1160                 1165                 1170             


Asn Ser  Phe Ala Glu Trp His  Ser Ser Tyr Cys Leu  Lys 
    1175                 1180                 1185     


<210>  3820
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM178B__Homo_sapiens__NP_001116118

<400>  3820

Met Trp Pro Arg Leu Pro Gly Ala Gly Leu Ala Pro Gln Leu Arg Arg 
1               5                   10                  15      


Gln Asp Gln Arg Leu His Phe Thr Gly Gln Met Ser His Gly Leu Gln 
            20                  25                  30          


Met Ala Gly Pro Gln Glu Thr Val Leu Ala Leu Pro Leu Arg Glu Gly 
        35                  40                  45              


Val Gln Ala Ala Ala Thr Val Pro Ile Leu Leu Tyr Asn Leu Glu Asp 
    50                  55                  60                  


Gly Leu Ser Asp His Pro Leu Asp Gln Gly Pro Arg Cys Pro Ala Arg 
65                  70                  75                  80  


Arg Pro Cys Ser Pro Ala Ser Ala Pro Ala Pro Thr Ser Pro Lys Lys 
                85                  90                  95      


Pro Lys Ile Gln Ala Pro Gly Glu Thr Phe Pro Thr Asp Trp Ser Pro 
            100                 105                 110         


Pro Pro Val Glu Phe Leu Asn Pro Arg Val Leu Gln Ala Ser Arg Glu 
        115                 120                 125             


Ala Pro Ala Gln Arg Trp Val Gly Val Val Gly Pro Gln Gly Leu Arg 
    130                 135                 140                 


Arg Leu Ala Gly Glu Leu Pro Glu Glu Leu Glu Gln Glu His Leu Asp 
145                 150                 155                 160 


Leu Asp Pro Lys Arg Gly Leu Ala Leu Pro Glu Lys Leu Phe Trp Asn 
                165                 170                 175     


Thr Ser Gly Leu Ser Gln Gln Ala Ala Ala Pro Glu Phe Ser Trp Gly 
            180                 185                 190         


Gly Ser Gly Ser Tyr Phe Asn Asn Leu Asp Tyr Leu Leu Gln Glu Lys 
        195                 200                 205             


Arg Glu Gln Ala Leu Glu Gln Glu Arg Glu Arg Leu Leu Leu Gln Glu 
    210                 215                 220                 


Cys Leu Asn Leu Asn Ser Leu Asp Leu Asp Glu Glu Glu Val Pro Leu 
225                 230                 235                 240 


Thr Pro Glu His Arg Met Leu Val Glu Lys Tyr Ser Val Ser Leu Gln 
                245                 250                 255     


Thr Ile Pro Pro Val His Pro Gly Glu Thr Val Phe Leu Pro Arg Cys 
            260                 265                 270         


His Pro Leu Pro Cys Ile Leu Asp Ser Ser Leu Leu Lys Pro Arg Ser 
        275                 280                 285             


His Leu Glu Gly Leu Phe Leu Ser Ser Pro Pro Ala Gln Gln Leu Ser 
    290                 295                 300                 


Phe Leu Arg Ser Gly Leu Leu Asn Ile Leu Tyr Leu His Met Pro Asp 
305                 310                 315                 320 


Cys Pro Val Ser Leu Leu Gln Trp Leu Phe Gln Leu Leu Thr Trp Pro 
                325                 330                 335     


Pro Glu Thr Ser Leu Gly Ala Phe Gly Leu Leu Trp Asp Leu Ile Val 
            340                 345                 350         


Asp Gly Ile Phe Leu Gln Pro Asp Glu Asp Lys His Leu Trp Cys Pro 
        355                 360                 365             


Ser Leu Gln Glu Val Arg Glu Ala Phe His Ser Leu Gly Ala His Ser 
    370                 375                 380                 


Pro Ala Leu Tyr Pro Leu Gly Pro Phe Trp His Gly Gly Arg Val Leu 
385                 390                 395                 400 


Pro Gly Glu Ala Gly Leu Asn Glu Asn Glu Glu Gln Asp Ala Pro Gln 
                405                 410                 415     


Glu Ile Ala Leu Asp Ile Ser Leu Gly His Ile Tyr Lys Phe Leu Ala 
            420                 425                 430         


Leu Cys Ala Gln Ala Gln Pro Gly Ala Tyr Thr Asp Glu Asn Leu Met 
        435                 440                 445             


Gly Leu Ile Glu Leu Leu Cys Arg Thr Ser Leu Asp Val Gly Leu Arg 
    450                 455                 460                 


Leu Leu Pro Lys Val Asp Leu Gln Gln Leu Leu Leu Leu Leu Leu Glu 
465                 470                 475                 480 


Asn Ile Arg Glu Trp Pro Gly Lys Leu Gln Glu Leu Cys Cys Thr Leu 
                485                 490                 495     


Ser Trp Val Ser Asp His His His Asn Leu Leu Ala Leu Val Gln Phe 
            500                 505                 510         


Phe Pro Asp Met Thr Ser Arg Ser Arg Arg Leu Arg Ser Gln Leu Ser 
        515                 520                 525             


Leu Val Val Ile Ala Arg Met Leu Gly Gln Gln Glu Met Leu Pro Leu 
    530                 535                 540                 


Trp Gln Glu Lys Thr Gln Leu Ser Ser Leu Ser Arg Leu Leu Gly Leu 
545                 550                 555                 560 


Met Arg Pro Ser Ser Leu Arg Gln Tyr Leu Asp Ser Val Pro Leu Pro 
                565                 570                 575     


Pro Cys Gln Glu Gln Gln Pro Lys Ala Ser Ala Glu Leu Asp His Lys 
            580                 585                 590         


Ala Cys Tyr Leu Cys His Ser Leu Leu Met Leu Ala Gly Val Val Val 
        595                 600                 605             


Ser Cys Gln Asp Ile Thr Pro Asp Gln Trp Gly Glu Leu Gln Leu Leu 
    610                 615                 620                 


Cys Met Gln Leu Asp Arg His Ile Ser Thr Gln Ile Arg Glu Ser Pro 
625                 630                 635                 640 


Gln Ala Met His Arg Thr Met Leu Lys Asp Leu Ala Thr Gln Thr Tyr 
                645                 650                 655     


Ile Arg Trp Gln Glu Leu Leu Thr His Cys Gln Pro Gln Ala Gln Tyr 
            660                 665                 670         


Phe Ser Pro Trp Lys Asp Ile 
        675                 


<210>  3821
<211>  1720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM179B__Homo_sapiens__NP_055906

<400>  3821

Met Ala Ala Ala Pro Ser Ala Leu Leu Leu Leu Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Ser Thr Tyr Arg Leu Gln Ser Arg Ser Arg Pro Ser Ala Pro Glu 
            20                  25                  30          


Thr Asp Asp Ser Arg Val Gly Gly Ile Met Arg Gly Glu Lys Asn Tyr 
        35                  40                  45              


Tyr Phe Arg Gly Ala Ala Gly Asp His Gly Ser Cys Pro Thr Thr Thr 
    50                  55                  60                  


Ser Pro Leu Ala Ser Ala Leu Leu Met Pro Ser Glu Ala Val Ser Ser 
65                  70                  75                  80  


Ser Trp Ser Glu Ser Gly Gly Gly Leu Ser Gly Gly Asp Glu Glu Asp 
                85                  90                  95      


Thr Arg Leu Leu Gln Leu Leu Arg Thr Ala Arg Asp Pro Ser Glu Ala 
            100                 105                 110         


Phe Gln Ala Leu Gln Ala Ala Leu Pro Arg Arg Gly Gly Arg Leu Gly 
        115                 120                 125             


Phe Pro Arg Arg Lys Glu Ala Leu Tyr Arg Ala Leu Gly Arg Val Leu 
    130                 135                 140                 


Val Glu Gly Gly Ser Asp Glu Lys Arg Leu Cys Leu Gln Leu Leu Ser 
145                 150                 155                 160 


Asp Val Leu Arg Gly Gln Gly Glu Ala Gly Gln Leu Glu Glu Ala Phe 
                165                 170                 175     


Ser Leu Ala Leu Leu Pro Gln Leu Val Val Ser Leu Arg Glu Glu Asn 
            180                 185                 190         


Pro Ala Leu Arg Lys Asp Ala Leu Gln Ile Leu His Ile Cys Leu Lys 
        195                 200                 205             


Arg Ser Pro Gly Glu Val Leu Arg Thr Leu Ile Gln Gln Gly Leu Glu 
    210                 215                 220                 


Ser Thr Asp Ala Arg Leu Arg Ala Ser Thr Ala Leu Leu Leu Pro Ile 
225                 230                 235                 240 


Leu Leu Thr Thr Glu Asp Leu Leu Leu Gly Leu Asp Leu Thr Glu Val 
                245                 250                 255     


Ile Ile Ser Leu Ala Arg Lys Leu Gly Asp Gln Glu Thr Glu Glu Glu 
            260                 265                 270         


Ser Glu Thr Ala Phe Ser Ala Leu Gln Gln Ile Gly Glu Arg Leu Gly 
        275                 280                 285             


Gln Asp Arg Phe Gln Ser Tyr Ile Ser Arg Leu Pro Ser Ala Leu Arg 
    290                 295                 300                 


Arg His Tyr Asn Arg Arg Leu Glu Ser Gln Phe Gly Ser Gln Val Pro 
305                 310                 315                 320 


Tyr Tyr Leu Glu Leu Glu Ala Ser Gly Phe Pro Glu Asp Pro Leu Pro 
                325                 330                 335     


Cys Ala Val Thr Leu Ser Asn Ser Asn Leu Lys Phe Gly Ile Ile Pro 
            340                 345                 350         


Gln Glu Leu His Ser Arg Leu Leu Asp Gln Glu Asp Tyr Lys Asn Arg 
        355                 360                 365             


Thr Gln Ala Val Glu Glu Leu Lys Gln Val Leu Gly Lys Phe Asn Pro 
    370                 375                 380                 


Ser Ser Thr Pro His Ser Ser Leu Val Gly Phe Ile Ser Leu Leu Tyr 
385                 390                 395                 400 


Asn Leu Leu Asp Asp Ser Asn Phe Lys Val Val His Gly Thr Leu Glu 
                405                 410                 415     


Val Leu His Leu Leu Val Ile Arg Leu Gly Glu Gln Val Gln Gln Phe 
            420                 425                 430         


Leu Gly Pro Val Ile Ala Ala Ser Val Lys Val Leu Ala Asp Asn Lys 
        435                 440                 445             


Leu Val Ile Lys Gln Glu Tyr Met Lys Ile Phe Leu Lys Leu Met Lys 
    450                 455                 460                 


Glu Val Gly Pro Gln Gln Val Leu Cys Leu Leu Leu Glu His Leu Lys 
465                 470                 475                 480 


His Lys His Ser Arg Val Arg Glu Glu Val Val Asn Ile Cys Ile Cys 
                485                 490                 495     


Ser Leu Leu Thr Tyr Pro Ser Glu Asp Phe Asp Leu Pro Lys Leu Ser 
            500                 505                 510         


Phe Asp Leu Ala Pro Ala Leu Val Asp Ser Lys Arg Arg Val Arg Gln 
        515                 520                 525             


Ala Ala Leu Glu Ala Phe Ala Val Leu Ala Ser Ser Met Gly Ser Gly 
    530                 535                 540                 


Lys Thr Ser Ile Leu Phe Lys Ala Val Asp Thr Val Glu Leu Gln Asp 
545                 550                 555                 560 


Asn Gly Asp Gly Val Met Asn Ala Val Gln Ala Arg Leu Ala Arg Lys 
                565                 570                 575     


Thr Leu Pro Arg Leu Thr Glu Gln Gly Phe Val Glu Tyr Ala Val Leu 
            580                 585                 590         


Met Pro Ser Ser Ala Gly Gly Arg Ser Asn His Leu Ala His Gly Ala 
        595                 600                 605             


Asp Thr Asp Trp Leu Leu Ala Gly Asn Arg Thr Gln Ser Ala His Cys 
    610                 615                 620                 


His Cys Gly Asp His Val Arg Asp Ser Met His Ile Tyr Gly Ser Tyr 
625                 630                 635                 640 


Ser Pro Thr Ile Cys Thr Arg Arg Val Leu Ser Ala Gly Lys Gly Lys 
                645                 650                 655     


Asn Lys Leu Pro Trp Glu Asn Glu Gln Pro Gly Ile Met Gly Glu Asn 
            660                 665                 670         


Gln Thr Ser Thr Ser Lys Asp Ile Glu Gln Phe Ser Thr Tyr Asp Phe 
        675                 680                 685             


Ile Pro Ser Ala Lys Leu Lys Leu Ser Gln Gly Met Pro Val Asn Asp 
    690                 695                 700                 


Asp Leu Cys Phe Ser Arg Lys Arg Val Ser Arg Asn Leu Phe Gln Asn 
705                 710                 715                 720 


Ser Arg Asp Phe Asn Pro Asp Cys Leu Pro Leu Cys Ala Ala Gly Thr 
                725                 730                 735     


Thr Gly Thr His Gln Thr Asn Leu Ser Gly Lys Cys Ala Gln Leu Gly 
            740                 745                 750         


Phe Ser Gln Ile Cys Gly Lys Thr Gly Ser Val Gly Ser Asp Leu Gln 
        755                 760                 765             


Phe Leu Gly Thr Thr Ser Ser His Gln Glu Lys Val Tyr Ala Ser Leu 
    770                 775                 780                 


Asn Phe Gly Ser Lys Thr Gln Gln Thr Phe Gly Ser Gln Thr Glu Cys 
785                 790                 795                 800 


Thr Ser Ser Asn Gly Gln Asn Pro Ser Pro Gly Ala Tyr Ile Leu Pro 
                805                 810                 815     


Ser Tyr Pro Val Ser Ser Pro Arg Thr Ser Pro Lys His Thr Ser Pro 
            820                 825                 830         


Leu Ile Ile Ser Pro Lys Lys Ser Gln Asp Asn Ser Val Asn Phe Ser 
        835                 840                 845             


Asn Ser Trp Pro Leu Lys Ser Phe Glu Gly Leu Ser Lys Pro Ser Pro 
    850                 855                 860                 


Gln Lys Lys Leu Val Ser Gln Lys Ser Ser Asp Pro Thr Gly Arg Asn 
865                 870                 875                 880 


His Gly Glu Asn Ser Gln Glu Lys Pro Pro Val Gln Leu Thr Pro Ala 
                885                 890                 895     


Leu Val Arg Ser Pro Ser Ser Arg Arg Gly Leu Asn Gly Thr Lys Pro 
            900                 905                 910         


Val Pro Pro Ile Pro Arg Gly Ile Ser Leu Leu Pro Asp Lys Ala Asp 
        915                 920                 925             


Leu Ser Thr Val Gly His Lys Lys Lys Glu Pro Asp Asp Ile Trp Lys 
    930                 935                 940                 


Cys Glu Lys Asp Ser Leu Pro Ile Asp Leu Ser Glu Leu Asn Phe Lys 
945                 950                 955                 960 


Asp Lys Asp Leu Asp Gln Glu Glu Met His Ser Ser Leu Arg Ser Leu 
                965                 970                 975     


Arg Asn Ser Ala Ala Lys Lys Arg Ala Lys Leu Ser Gly Ser Thr Ser 
            980                 985                 990         


Asp Leu Glu Ser Pro Asp Ser Ala  Met Lys Leu Asp Leu  Thr Met Asp 
        995                 1000                 1005             


Ser Pro  Ser Leu Ser Ser Ser  Pro Asn Ile Asn Ser  Tyr Ser Glu 
    1010                 1015                 1020             


Ser Gly  Val Tyr Ser Gln Glu  Ser Leu Thr Ser Ser  Leu Ser Thr 
    1025                 1030                 1035             


Thr Pro  Gln Gly Lys Arg Ile  Met Ser Asp Ile Phe  Pro Thr Phe 
    1040                 1045                 1050             


Gly Ser  Lys Pro Cys Pro Thr  Arg Leu Ser Ser Ala  Lys Lys Lys 
    1055                 1060                 1065             


Ile Ser  His Ile Ala Glu Gln  Ser Pro Ser Ala Gly  Ser Ser Ser 
    1070                 1075                 1080             


Asn Pro  Gln Gln Ile Ser Ser  Phe Asp Phe Thr Thr  Thr Lys Ala 
    1085                 1090                 1095             


Leu Ser  Glu Asp Ser Val Val  Val Val Gly Lys Gly  Val Phe Gly 
    1100                 1105                 1110             


Ser Leu  Ser Ser Ala Pro Ala  Thr Cys Ser Gln Ser  Val Ile Ser 
    1115                 1120                 1125             


Ser Val  Glu Asn Gly Asp Thr  Phe Ser Ile Lys Gln  Ser Ile Glu 
    1130                 1135                 1140             


Pro Pro  Ser Gly Ile Tyr Gly  Arg Ser Val Gln Gln  Asn Ile Ser 
    1145                 1150                 1155             


Ser Tyr  Leu Asp Val Glu Asn  Glu Lys Asp Ala Lys  Val Ser Ile 
    1160                 1165                 1170             


Ser Lys  Ser Thr Tyr Asn Lys  Met Arg Gln Lys Arg  Lys Glu Glu 
    1175                 1180                 1185             


Lys Glu  Leu Phe His Asn Lys  Asp Cys Glu Lys Lys  Glu Lys Asn 
    1190                 1195                 1200             


Ser Trp  Glu Arg Met Arg His  Thr Gly Thr Glu Lys  Met Ala Ser 
    1205                 1210                 1215             


Glu Ser  Glu Thr Pro Thr Gly  Ala Ile Ser Gln Tyr  Lys Glu Arg 
    1220                 1225                 1230             


Met Pro  Ser Val Thr His Ser  Pro Glu Ile Met Asp  Leu Ser Glu 
    1235                 1240                 1245             


Leu Arg  Pro Phe Ser Lys Pro  Glu Ile Ala Leu Thr  Glu Ala Leu 
    1250                 1255                 1260             


Arg Leu  Leu Ala Asp Glu Asp  Trp Glu Lys Lys Ile  Glu Gly Leu 
    1265                 1270                 1275             


Asn Phe  Ile Arg Cys Leu Ala  Ala Phe His Ser Glu  Ile Leu Asn 
    1280                 1285                 1290             


Thr Lys  Leu His Glu Thr Asn  Phe Ala Val Val Gln  Glu Val Lys 
    1295                 1300                 1305             


Asn Leu  Arg Ser Gly Val Ser  Arg Ala Ala Val Val  Cys Leu Ser 
    1310                 1315                 1320             


Asp Leu  Phe Thr Tyr Leu Lys  Lys Ser Met Asp Gln  Glu Leu Asp 
    1325                 1330                 1335             


Thr Thr  Val Lys Val Leu Leu  His Lys Ala Gly Glu  Ser Asn Thr 
    1340                 1345                 1350             


Phe Ile  Arg Glu Asp Val Asp  Lys Ala Leu Arg Ala  Met Val Asn 
    1355                 1360                 1365             


Asn Val  Thr Pro Ala Arg Ala  Val Val Ser Leu Ile  Asn Gly Gly 
    1370                 1375                 1380             


Gln Arg  Tyr Tyr Gly Arg Lys  Met Leu Phe Phe Met  Met Cys His 
    1385                 1390                 1395             


Pro Asn  Phe Glu Lys Met Leu  Glu Lys Tyr Val Pro  Ser Lys Asp 
    1400                 1405                 1410             


Leu Pro  Tyr Ile Lys Asp Ser  Val Arg Asn Leu Gln  Gln Lys Gly 
    1415                 1420                 1425             


Leu Gly  Glu Ile Pro Leu Asp  Thr Pro Ser Ala Lys  Gly Arg Arg 
    1430                 1435                 1440             


Ser His  Thr Gly Ser Val Gly  Asn Thr Arg Ser Ser  Ser Val Ser 
    1445                 1450                 1455             


Arg Asp  Ala Phe Asn Ser Ala  Glu Arg Ala Val Thr  Glu Val Arg 
    1460                 1465                 1470             


Glu Val  Thr Arg Lys Ser Val  Pro Arg Asn Ser Leu  Glu Ser Ala 
    1475                 1480                 1485             


Glu Tyr  Leu Lys Leu Ile Thr  Gly Leu Leu Asn Ala  Lys Asp Phe 
    1490                 1495                 1500             


Arg Asp  Arg Ile Asn Gly Ile  Lys Gln Leu Leu Ser  Asp Thr Glu 
    1505                 1510                 1515             


Asn Asn  Gln Asp Leu Val Val  Gly Asn Ile Val Lys  Ile Phe Asp 
    1520                 1525                 1530             


Ala Phe  Lys Ser Arg Leu His  Asp Ser Asn Ser Lys  Val Asn Leu 
    1535                 1540                 1545             


Val Ala  Leu Glu Thr Met His  Lys Met Ile Pro Leu  Leu Arg Asp 
    1550                 1555                 1560             


His Leu  Ser Pro Ile Ile Asn  Met Leu Ile Pro Ala  Ile Val Asp 
    1565                 1570                 1575             


Asn Asn  Leu Asn Ser Lys Asn  Pro Gly Ile Tyr Ala  Ala Ala Thr 
    1580                 1585                 1590             


Asn Val  Val Gln Ala Leu Ser  Gln His Val Asp Asn  Tyr Leu Leu 
    1595                 1600                 1605             


Leu Gln  Pro Phe Cys Thr Lys  Ala Gln Phe Leu Asn  Gly Lys Ala 
    1610                 1615                 1620             


Lys Gln  Asp Met Thr Glu Lys  Leu Ala Asp Ile Val  Thr Glu Leu 
    1625                 1630                 1635             


Tyr Gln  Arg Lys Pro His Ala  Thr Glu Gln Lys Val  Leu Val Val 
    1640                 1645                 1650             


Leu Trp  His Leu Leu Gly Asn  Met Thr Asn Ser Gly  Ser Leu Pro 
    1655                 1660                 1665             


Gly Ala  Gly Gly Asn Ile Arg  Thr Ala Thr Ala Lys  Leu Ser Lys 
    1670                 1675                 1680             


Ala Leu  Phe Ala Gln Met Gly  Gln Asn Leu Leu Asn  Gln Ala Ala 
    1685                 1690                 1695             


Ser Gln  Pro Pro His Ile Lys  Lys Ser Leu Glu Glu  Leu Leu Asp 
    1700                 1705                 1710             


Met Thr  Ile Leu Asn Glu Leu  
    1715                 1720 


<210>  3822
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM180A__Homo_sapiens__NP_995327

<400>  3822

Met His Trp Lys Met Leu Leu Leu Leu Leu Leu Tyr Tyr Asn Ala Glu 
1               5                   10                  15      


Ala Ser Met Cys His Arg Trp Ser Arg Ala Val Leu Phe Pro Ala Ala 
            20                  25                  30          


His Arg Pro Lys Arg Ser Ser Ser Leu Pro Leu Asn Pro Val Leu Gln 
        35                  40                  45              


Thr Ser Leu Glu Glu Val Glu Leu Leu Tyr Glu Phe Leu Leu Ala Glu 
    50                  55                  60                  


Leu Glu Ile Ser Pro Asp Leu Gln Ile Ser Ile Lys Asp Glu Glu Leu 
65                  70                  75                  80  


Ala Ser Leu Arg Lys Ala Ser Asp Phe Arg Thr Val Cys Asn Asn Val 
                85                  90                  95      


Ile Pro Lys Ser Ile Pro Asp Ile Arg Arg Leu Ser Ala Ser Leu Ser 
            100                 105                 110         


Ser His Pro Gly Ile Leu Lys Lys Glu Asp Phe Glu Arg Thr Val Leu 
        115                 120                 125             


Thr Leu Ala Tyr Thr Ala Tyr Arg Thr Ala Leu Ser His Gly His Gln 
    130                 135                 140                 


Lys Asp Ile Trp Ala Gln Ser Leu Val Ser Leu Phe Gln Ala Leu Arg 
145                 150                 155                 160 


His Asp Leu Met Arg Ser Ser Gln Pro Gly Val Pro Pro 
                165                 170             


<210>  3823
<211>  971
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM184A__Homo_sapiens__NP_001093881

<400>  3823

Met Lys Gln Gln Ala Leu Thr Glu Phe Glu Ala Tyr Lys His Arg Val 
1               5                   10                  15      


Glu Asp Met Gln Leu Cys Ala Glu Ala Gln His Val Gln Arg Ile Val 
            20                  25                  30          


Thr Met Ser Arg Glu Val Glu Glu Ile Arg Arg Lys Phe Glu Glu Lys 
        35                  40                  45              


Leu Arg Ser Phe Gly Gln Leu Gln Val Gln Phe Glu Lys Asp Lys Arg 
    50                  55                  60                  


Leu Ala Leu Glu Asp Leu Gln Ala Ala His Arg Arg Glu Ile Gln Glu 
65                  70                  75                  80  


Leu Leu Lys Ser Gln Gln Asp His Ser Ala Ser Val Asn Lys Gly Gln 
                85                  90                  95      


Glu Lys Ala Glu Glu Leu His Arg Met Glu Val Glu Ser Leu Asn Lys 
            100                 105                 110         


Met Leu Glu Glu Leu Arg Leu Glu Arg Lys Lys Leu Ile Glu Asp Tyr 
        115                 120                 125             


Glu Gly Lys Leu Asn Lys Ala Gln Ser Phe Tyr Glu Arg Glu Leu Asp 
    130                 135                 140                 


Thr Leu Lys Arg Ser Gln Leu Phe Thr Ala Glu Ser Leu Gln Ala Ser 
145                 150                 155                 160 


Lys Glu Lys Glu Ala Asp Leu Arg Lys Glu Phe Gln Gly Gln Glu Ala 
                165                 170                 175     


Ile Leu Arg Lys Thr Ile Gly Lys Leu Lys Thr Glu Leu Gln Met Val 
            180                 185                 190         


Gln Asp Glu Ala Gly Ser Leu Leu Asp Lys Cys Gln Lys Leu Gln Thr 
        195                 200                 205             


Ala Leu Ala Ile Ala Glu Asn Asn Val Gln Val Leu Gln Lys Gln Leu 
    210                 215                 220                 


Asp Asp Ala Lys Glu Gly Glu Met Ala Leu Leu Ser Lys His Lys Glu 
225                 230                 235                 240 


Val Glu Ser Glu Leu Ala Ala Ala Arg Glu Arg Leu Gln Gln Gln Ala 
                245                 250                 255     


Ser Asp Leu Val Leu Lys Ala Ser His Ile Gly Met Leu Gln Ala Thr 
            260                 265                 270         


Gln Met Thr Gln Glu Val Thr Ile Lys Asp Leu Glu Ser Glu Lys Ser 
        275                 280                 285             


Arg Val Asn Glu Arg Leu Ser Gln Leu Glu Glu Glu Arg Ala Phe Leu 
    290                 295                 300                 


Arg Ser Lys Thr Gln Ser Leu Asp Glu Glu Gln Lys Gln Gln Ile Leu 
305                 310                 315                 320 


Glu Leu Glu Lys Lys Val Asn Glu Ala Lys Arg Thr Gln Gln Glu Tyr 
                325                 330                 335     


Tyr Glu Arg Glu Leu Lys Asn Leu Gln Ser Arg Leu Glu Glu Glu Val 
            340                 345                 350         


Thr Gln Leu Asn Glu Ala His Ser Lys Thr Leu Glu Glu Leu Ala Trp 
        355                 360                 365             


Lys His His Met Ala Ile Glu Ala Val His Ser Asn Ala Ile Arg Asp 
    370                 375                 380                 


Lys Lys Lys Leu Gln Met Asp Leu Glu Glu Gln His Asn Lys Asp Lys 
385                 390                 395                 400 


Leu Asn Leu Glu Glu Asp Lys Asn Gln Leu Gln Gln Glu Leu Glu Asn 
                405                 410                 415     


Leu Lys Glu Val Leu Glu Asp Lys Leu Asn Thr Ala Asn Gln Glu Ile 
            420                 425                 430         


Gly His Leu Gln Asp Met Val Arg Lys Ser Glu Gln Gly Leu Gly Ser 
        435                 440                 445             


Ala Glu Gly Leu Ile Ala Ser Leu Gln Asp Ser Gln Glu Arg Leu Gln 
    450                 455                 460                 


Asn Glu Leu Asp Leu Thr Lys Asp Ser Leu Lys Glu Thr Lys Asp Ala 
465                 470                 475                 480 


Leu Leu Asn Val Glu Gly Glu Leu Glu Gln Glu Arg Gln Gln His Glu 
                485                 490                 495     


Glu Thr Ile Ala Ala Met Lys Glu Glu Glu Lys Leu Lys Val Asp Lys 
            500                 505                 510         


Met Ala His Asp Leu Glu Ile Lys Trp Thr Glu Asn Leu Arg Gln Glu 
        515                 520                 525             


Cys Ser Lys Leu Arg Glu Glu Leu Arg Leu Gln His Glu Glu Asp Lys 
    530                 535                 540                 


Lys Ser Ala Met Ser Gln Leu Leu Gln Leu Lys Asp Arg Glu Lys Asn 
545                 550                 555                 560 


Ala Ala Arg Asp Ser Trp Gln Lys Lys Val Glu Asp Leu Leu Asn Gln 
                565                 570                 575     


Ile Ser Leu Leu Lys Gln Asn Leu Glu Ile Gln Leu Ser Gln Ser Gln 
            580                 585                 590         


Thr Ser Leu Gln Gln Leu Gln Ala Gln Phe Thr Gln Glu Arg Gln Arg 
        595                 600                 605             


Leu Thr Gln Glu Leu Glu Glu Leu Glu Glu Gln His Gln Gln Arg His 
    610                 615                 620                 


Lys Ser Leu Lys Glu Ala His Val Leu Ala Phe Gln Thr Met Glu Glu 
625                 630                 635                 640 


Glu Lys Glu Lys Glu Gln Arg Ala Leu Glu Asn His Leu Gln Gln Lys 
                645                 650                 655     


His Ser Ala Glu Leu Gln Ser Leu Lys Asp Ala His Arg Glu Ser Met 
            660                 665                 670         


Glu Gly Phe Arg Ile Glu Met Glu Gln Glu Leu Gln Thr Leu Arg Phe 
        675                 680                 685             


Glu Leu Glu Asp Glu Gly Lys Ala Met Leu Ala Ser Leu Arg Ser Glu 
    690                 695                 700                 


Leu Asn His Gln His Ala Ala Ala Ile Asp Leu Leu Arg His Asn His 
705                 710                 715                 720 


His Gln Glu Leu Ala Ala Ala Lys Met Glu Leu Glu Arg Ser Ile Asp 
                725                 730                 735     


Ile Ser Arg Arg Gln Ser Lys Glu His Ile Cys Arg Ile Thr Asp Leu 
            740                 745                 750         


Gln Glu Glu Leu Arg His Arg Glu His His Ile Ser Glu Leu Asp Lys 
        755                 760                 765             


Glu Val Gln His Leu His Glu Asn Ile Ser Ala Leu Thr Lys Glu Leu 
    770                 775                 780                 


Glu Phe Lys Gly Lys Glu Ile Leu Arg Ile Arg Ser Glu Ser Asn Gln 
785                 790                 795                 800 


Gln Ile Arg Leu Glu Glu Met Glu Glu Lys Tyr Leu Met Arg Glu Ser 
                805                 810                 815     


Lys Pro Glu Asp Ile Gln Met Ile Thr Glu Leu Lys Ala Met Leu Thr 
            820                 825                 830         


Glu Arg Asp Gln Ile Ile Lys Lys Leu Ile Glu Asp Asn Lys Phe Tyr 
        835                 840                 845             


Gln Leu Glu Leu Val Asn Arg Glu Thr Asn Phe Asn Lys Val Phe Asn 
    850                 855                 860                 


Ser Ser Pro Thr Val Gly Val Ile Asn Pro Leu Ala Lys Gln Lys Lys 
865                 870                 875                 880 


Lys Asn Asp Lys Ser Pro Thr Asn Arg Phe Val Ser Val Pro Asn Leu 
                885                 890                 895     


Ser Ala Leu Glu Ser Gly Gly Val Gly Asn Gly His Pro Asn Arg Leu 
            900                 905                 910         


Asp Pro Ile Pro Asn Ser Pro Val His Asp Ile Glu Phe Asn Ser Ser 
        915                 920                 925             


Lys Pro Leu Pro Gln Pro Val Pro Pro Lys Gly Pro Lys Thr Phe Leu 
    930                 935                 940                 


Ser Pro Ala Gln Ser Glu Ala Ser Pro Val Ala Ser Pro Asp Pro Gln 
945                 950                 955                 960 


Arg Gln Glu Trp Phe Ala Arg Tyr Phe Thr Phe 
                965                 970     


<210>  3824
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM184B__Homo_sapiens__NP_056503

<400>  3824

Met Ala Ser Ala Leu Asn Ser Lys Ile Asn Pro Pro Gly Thr Cys Gln 
1               5                   10                  15      


Gly Ser Lys Ala Asp Gly Gly Ala Gly Trp Arg Met Asp Cys Asp Pro 
            20                  25                  30          


Gln Met His Val Lys Met Cys Lys Lys Ile Ala Gln Leu Thr Lys Val 
        35                  40                  45              


Ile Tyr Ala Leu Asn Thr Arg Gln Asp Glu Ala Glu Ala Ser Met Glu 
    50                  55                  60                  


Ala Leu Arg Glu Ala His Gln Glu Glu Leu Gln Asn Ala Val Ala Glu 
65                  70                  75                  80  


Thr Lys Ala Arg Leu Leu Gln Glu Gln Gly Cys Ala Glu Glu Glu Ala 
                85                  90                  95      


Leu Leu Gln Arg Ile Gln Ala Leu Glu Ser Ala Leu Glu Leu Gln Lys 
            100                 105                 110         


Arg Leu Thr Glu Glu Ala Leu Ala Glu Ser Ala Ser Cys Arg Leu Glu 
        115                 120                 125             


Thr Lys Glu Arg Glu Leu Arg Val Glu Ala Glu His Ala Glu Arg Val 
    130                 135                 140                 


Leu Thr Leu Ser Arg Glu Met Leu Glu Leu Lys Ala Asp Tyr Glu Arg 
145                 150                 155                 160 


Arg Leu Gln His Leu Thr Ser His Glu Ala Thr Pro Gln Gly Arg Leu 
                165                 170                 175     


Pro Gln Glu Ser Pro Glu Thr Lys Ser Glu Pro Gly Gln Gly Pro Glu 
            180                 185                 190         


Met Gln Glu Val Leu Leu Glu Val Gln Arg Leu Arg Val Glu Asn Gln 
        195                 200                 205             


Gln Leu Ser Lys Asp Tyr Ala Arg Lys Ala Glu Glu Leu Gln Ala Thr 
    210                 215                 220                 


Tyr Glu Arg Glu Asn Glu Ala Ile Arg Gln Ala Met Gln Gln Ser Val 
225                 230                 235                 240 


Ser Gln Ala Leu Trp Gln Trp Gln Glu Lys Glu Ser Asp Leu Arg Lys 
                245                 250                 255     


Asn Phe Gln Val Gln Glu Ser Ala Leu Gln Ala Gln Val Arg Lys Leu 
            260                 265                 270         


Glu Gly Asp Leu Glu His Arg Gly Arg Lys Ile Ser Asp Leu Lys Lys 
        275                 280                 285             


Tyr Ala Gln Lys Leu Lys Glu Arg Ile Gln Asp Leu Asp Val Gln Leu 
    290                 295                 300                 


Lys Glu Ala Arg Gln Glu Asn Ser Glu Leu Lys Gly Thr Ala Lys Lys 
305                 310                 315                 320 


Leu Gly Glu Lys Leu Ala Val Ala Lys Asp Arg Met Met Leu Gln Glu 
                325                 330                 335     


Cys Arg Gly Thr Gln Gln Thr Asp Ala Met Lys Thr Glu Leu Val Ser 
            340                 345                 350         


Glu Asn Lys Val Leu Arg Glu Glu Asn Asp Leu Glu Ala Gly Asn Leu 
        355                 360                 365             


His Pro Gln Gln Asp Gln Ser Cys Leu Lys Glu Cys Pro Cys Met Lys 
    370                 375                 380                 


Gly Gly Thr Asp Met Gln Thr Lys Lys Glu Ala Ser Ala Glu Thr Glu 
385                 390                 395                 400 


Tyr Met Lys Gln Gln Tyr Glu Glu Asp Leu Arg Lys Ile Lys His Gln 
                405                 410                 415     


Thr Glu Glu Glu Lys Lys His Leu Lys Asp Gln Leu Val Lys Arg Leu 
            420                 425                 430         


Glu Asp Leu Val Lys Lys His Thr Val Glu Ile Lys Ser Val Arg Ser 
        435                 440                 445             


Ser Val Glu Ala Glu Arg Lys Lys Leu Gln Arg Glu Val Glu Ala Gln 
    450                 455                 460                 


Leu Glu Glu Val Arg Lys Lys Ser Glu Lys Glu Ile Lys Gln Leu Glu 
465                 470                 475                 480 


Glu Glu Lys Ala Ala Leu Asn Val Lys Leu Gln Asn Ser Leu Leu Glu 
                485                 490                 495     


Val Leu Arg Leu Glu Glu Phe Ile Gln Gln Asn Lys Thr Arg Pro Thr 
            500                 505                 510         


Gly Ala Glu Glu Ser Pro Gln Glu Leu Gly Arg Gln His Cys Ser Ile 
        515                 520                 525             


Leu Glu Thr Gln Asp Pro Cys Leu Lys Leu Asp Glu Thr Ser Pro Arg 
    530                 535                 540                 


Gly Glu Glu Tyr Gln Asp Lys Leu Ala Ala Glu Glu Gly Thr Ser Ser 
545                 550                 555                 560 


Asp Glu Glu Glu Arg Thr Lys Val Leu Leu Lys Glu Gly Ser Asp Pro 
                565                 570                 575     


Gln Pro Pro Leu Gly Ser Leu Leu Lys Glu Lys Thr Ser Lys Ile Gln 
            580                 585                 590         


Arg Leu Glu Glu Asp Trp Gln Ser Gln Lys Ala Lys Leu Gln Ala Gln 
        595                 600                 605             


Val Ser Gln Met Gln Gln Ala Leu Glu Gln Cys Thr Ser Asn Tyr Arg 
    610                 615                 620                 


Glu Asp Leu Gln Ala Leu Lys Gln Leu Ser Asp Leu Glu Arg Glu Lys 
625                 630                 635                 640 


Leu Gln Arg Glu Leu Gln Glu Thr Thr Gln Gln Asn His Ala Met Lys 
                645                 650                 655     


Ala Gln Leu Glu Ala Ser His Gln Arg Ala Leu Arg Met Leu Glu Lys 
            660                 665                 670         


Ala Arg His Gln Glu Leu Lys Ala Thr Glu Glu Arg Leu Lys Lys Glu 
        675                 680                 685             


Ser Ser His Ser Leu Gln Ile Gln His Gln Thr His Arg Leu Glu Leu 
    690                 695                 700                 


Gln Ala Leu Glu Glu Lys Ala Arg Gln Glu Leu Gln Glu Glu Arg Glu 
705                 710                 715                 720 


Arg Met Gln Ala Gln Gln Ala Leu Leu Leu Glu Ser Leu Arg Gln Glu 
                725                 730                 735     


Leu Ser Glu Gln Gln Ala Ala Cys Ser Gly His Gln Lys Asp Leu Glu 
            740                 745                 750         


Ala Leu Gln Ala Glu Leu Arg Ala Leu Gly Arg Gln Gln Ala Ser Ser 
        755                 760                 765             


Gln Cys Pro Gly Asp Ser Lys Asp His Ile Ile Ala Thr Glu Glu Arg 
    770                 775                 780                 


Gly Gly Pro Gly Gln Ala Gly Ser Pro Pro Gly Ala Ala Gly Gln Gly 
785                 790                 795                 800 


Ser Gly Glu Gly Cys Gly Leu Trp Glu Glu Asn Ala Gln Leu Gln Asp 
                805                 810                 815     


Ala Val Arg Arg Leu Arg Ala Glu Val Glu Gln His Gln Gln Glu Ala 
            820                 825                 830         


Gln Lys Leu Arg Asp Gln Arg Arg Phe Leu Glu Glu Thr Gln Gln Ala 
        835                 840                 845             


Gln Arg Ala Arg Glu Val Glu Thr Leu Arg Gln Glu His Arg Lys Glu 
    850                 855                 860                 


Met Gln Ala Met Val Ala Asp Phe Ser Ser Ala Gln Ala Gln Leu Gln 
865                 870                 875                 880 


Ala Arg Leu Ala Ala Leu Glu Ala Glu Leu Lys Asp Ser Gly Glu Lys 
                885                 890                 895     


Pro Gly Lys Gly Ala Ser Arg Pro Glu Asp Leu Gln Leu Ile Gly Arg 
            900                 905                 910         


Leu Gln Thr Arg Leu Lys Glu Arg Glu Asp Ile Ile Lys Gln Leu Thr 
        915                 920                 925             


Glu Glu Arg Arg Phe His Tyr Ala Ala Phe Pro Ser Ala Met Ser His 
    930                 935                 940                 


Arg Asn Arg Ser Phe Ser Phe Asn Pro His Pro Gly Tyr Leu Thr Pro 
945                 950                 955                 960 


Ser Met Lys Lys Lys Lys Val Glu Asp Val Pro Ser Arg Val Val Ser 
                965                 970                 975     


Val Pro Asn Leu Ala Ser Tyr Ala Lys Asn Phe Leu Ser Gly Asp Leu 
            980                 985                 990         


Ser Ser Arg Ile Asn Ala Pro Pro  Ile Thr Thr Ser Pro  Ser Leu Asp 
        995                 1000                 1005             


Pro Ser  Pro Ser Cys Gly Arg  Thr Tyr Lys Pro Asn  Gln Ser Thr 
    1010                 1015                 1020             


Asp Ala  Lys Thr Ala Thr Arg  Thr Pro Asp Gly Glu  Thr Ala Gln 
    1025                 1030                 1035             


Ala Lys  Glu Val Gln Gln Lys  Gln Gly Ser Pro His  Gln Glu Trp 
    1040                 1045                 1050             


Phe Thr  Lys Tyr Phe Ser Phe  
    1055                 1060 


<210>  3825
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM187B__Homo_sapiens__NP_689694

<400>  3825

Met Pro Pro Met Leu Trp Leu Leu Leu His Phe Ala Ala Pro Ala Leu 
1               5                   10                  15      


Gly Phe Tyr Phe Ser Ile Ser Cys Pro Ser Gly Lys Gln Cys Gln Gln 
            20                  25                  30          


Ala Leu Leu Ser Gly Asn Asp Ile Leu Leu Tyr Cys Asn Ser Ser Gly 
        35                  40                  45              


Ala His Trp Tyr Tyr Leu Phe Thr Gln Gly Lys Lys Gly Arg Leu Thr 
    50                  55                  60                  


Ser Leu Thr Asn Ile Ser Asn Met Glu Ile Met Pro Glu Gly Ser Leu 
65                  70                  75                  80  


Leu Ile Lys Asp Pro Leu Pro Ser Gln Thr Gly Leu Tyr His Cys Trp 
                85                  90                  95      


Asn Lys Asn Gly Arg Gln Val Val Gln Tyr Glu Ile Asp Phe Gln Asp 
            100                 105                 110         


Val Thr Thr Leu His Ile Thr His Lys Asp Leu Gly Gln Arg Pro Leu 
        115                 120                 125             


Gln Asn Glu Thr Leu His Leu Gly Ser Lys Gln Leu Ile Phe Thr Trp 
    130                 135                 140                 


Trp Glu Pro Trp Gln Asp Cys Asn Arg Cys Glu Glu Pro Gly Glu Cys 
145                 150                 155                 160 


Lys Arg Leu Gly Tyr Arg Tyr Ile Glu Glu Pro Leu Glu Glu Ala Met 
                165                 170                 175     


Pro Cys Trp Leu Tyr Leu Gly Glu Val Leu Val Trp Ser Ser Arg Leu 
            180                 185                 190         


Arg Pro Glu Leu Gln Val Glu Ala Cys His Val Gln Cys Thr Asn Asn 
        195                 200                 205             


Thr Gln Leu Arg Val Asp Tyr Val Ile Phe Asp Asn Phe Arg Leu Asp 
    210                 215                 220                 


Glu Lys Thr Glu Phe Val Trp Leu Asp Cys Pro Leu Gly Ser Met Tyr 
225                 230                 235                 240 


Arg Pro Val Asn Trp Arg Ala Asn Asp Thr Pro Leu Thr Trp Glu Ser 
                245                 250                 255     


Gln Leu Ser Gly Gln Asp Phe Thr Thr Phe Leu Asp Pro Ser Thr Gly 
            260                 265                 270         


Gly Arg Gln Leu Gln Val Phe Gln Pro Ala Val Tyr Lys Cys Phe Val 
        275                 280                 285             


Gln Gln Glu Leu Val Ala Gln Phe Lys Pro Ala Ala Ser Leu Glu Thr 
    290                 295                 300                 


Leu Glu Ala Gln Trp Arg Glu Asn Asp Ala Gln Trp Arg Glu Ala Arg 
305                 310                 315                 320 


Lys Ala Leu Arg Gly Arg Ala Asp Ser Val Leu Lys Gly Leu Lys Leu 
                325                 330                 335     


Val Leu Leu Val Val Thr Val Leu Ala Leu Leu Gly Ala Leu Leu Lys 
            340                 345                 350         


Cys Ile His Pro Ser Pro Gly Arg Arg Ser Thr Gln Val Leu Val Val 
        355                 360                 365             


Lys 
    


<210>  3826
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM188A__Homo_sapiens__NP_079224

<400>  3826

Met Ser Glu Leu Thr Lys Glu Leu Met Glu Leu Val Trp Gly Thr Lys 
1               5                   10                  15      


Ser Ser Pro Gly Leu Ser Asp Thr Ile Phe Cys Arg Trp Thr Gln Gly 
            20                  25                  30          


Phe Val Phe Ser Glu Ser Glu Gly Ser Ala Leu Glu Gln Phe Glu Gly 
        35                  40                  45              


Gly Pro Cys Ala Val Ile Ala Pro Val Gln Ala Phe Leu Leu Lys Lys 
    50                  55                  60                  


Leu Leu Phe Ser Ser Glu Lys Ser Ser Trp Arg Asp Cys Ser Glu Glu 
65                  70                  75                  80  


Glu Gln Lys Glu Leu Leu Cys His Thr Leu Cys Asp Ile Leu Glu Ser 
                85                  90                  95      


Ala Cys Cys Asp His Ser Gly Ser Tyr Cys Leu Val Ser Trp Leu Arg 
            100                 105                 110         


Gly Lys Thr Thr Glu Glu Thr Ala Ser Ile Ser Gly Ser Pro Ala Glu 
        115                 120                 125             


Ser Ser Cys Gln Val Glu His Ser Ser Ala Leu Ala Val Glu Glu Leu 
    130                 135                 140                 


Gly Phe Glu Arg Phe His Ala Leu Ile Gln Lys Arg Ser Phe Arg Ser 
145                 150                 155                 160 


Leu Pro Glu Leu Lys Asp Ala Val Leu Asp Gln Tyr Ser Met Trp Gly 
                165                 170                 175     


Asn Lys Phe Gly Val Leu Leu Phe Leu Tyr Ser Val Leu Leu Thr Lys 
            180                 185                 190         


Gly Ile Glu Asn Ile Lys Asn Glu Ile Glu Asp Ala Ser Glu Pro Leu 
        195                 200                 205             


Ile Asp Pro Val Tyr Gly His Gly Ser Gln Ser Leu Ile Asn Leu Leu 
    210                 215                 220                 


Leu Thr Gly His Ala Val Ser Asn Val Trp Asp Gly Asp Arg Glu Cys 
225                 230                 235                 240 


Ser Gly Met Lys Leu Leu Gly Ile His Glu Gln Ala Ala Val Gly Phe 
                245                 250                 255     


Leu Thr Leu Met Glu Ala Leu Arg Tyr Cys Lys Val Gly Ser Tyr Leu 
            260                 265                 270         


Lys Ser Pro Lys Phe Pro Ile Trp Ile Val Gly Ser Glu Thr His Leu 
        275                 280                 285             


Thr Val Phe Phe Ala Lys Asp Met Ala Leu Val Ala Pro Glu Ala Pro 
    290                 295                 300                 


Ser Glu Gln Ala Arg Arg Val Phe Gln Thr Tyr Asp Pro Glu Asp Asn 
305                 310                 315                 320 


Gly Phe Ile Pro Asp Ser Leu Leu Glu Asp Val Met Lys Ala Leu Asp 
                325                 330                 335     


Leu Val Ser Asp Pro Glu Tyr Ile Asn Leu Met Lys Asn Lys Leu Asp 
            340                 345                 350         


Pro Glu Gly Leu Gly Ile Ile Leu Leu Gly Pro Phe Leu Gln Glu Phe 
        355                 360                 365             


Phe Pro Asp Gln Gly Ser Ser Gly Pro Glu Ser Phe Thr Val Tyr His 
    370                 375                 380                 


Tyr Asn Gly Leu Lys Gln Ser Asn Tyr Asn Glu Lys Val Met Tyr Val 
385                 390                 395                 400 


Glu Gly Thr Ala Val Val Met Gly Phe Glu Asp Pro Met Leu Gln Thr 
                405                 410                 415     


Asp Asp Thr Pro Ile Lys Arg Cys Leu Gln Thr Lys Trp Pro Tyr Ile 
            420                 425                 430         


Glu Leu Leu Trp Thr Thr Asp Arg Ser Pro Ser Leu Asn 
        435                 440                 445 


<210>  3827
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM188B__Homo_sapiens__NP_115598

<400>  3827

Met Asp Ser Leu Phe Val Glu Glu Val Ala Ala Ser Leu Val Arg Glu 
1               5                   10                  15      


Phe Leu Ser Arg Lys Gly Leu Lys Lys Thr Cys Val Thr Met Asp Gln 
            20                  25                  30          


Glu Arg Pro Arg Ser Asp Leu Ser Ile Asn Asn Arg Asn Asp Leu Arg 
        35                  40                  45              


Lys Val Leu His Leu Glu Phe Leu Tyr Lys Glu Asn Lys Ala Lys Glu 
    50                  55                  60                  


Asn Pro Leu Lys Thr Ser Leu Glu Leu Ile Thr Arg Tyr Phe Leu Asp 
65                  70                  75                  80  


His Phe Gly Asn Thr Ala Asn Asn Phe Thr Gln Asp Thr Pro Ile Pro 
                85                  90                  95      


Ala Leu Ser Val Pro Lys Lys Asn Asn Lys Val Pro Ser Arg Cys Ser 
            100                 105                 110         


Glu Thr Thr Leu Val Asn Ile Tyr Asp Leu Ser Asp Glu Asp Ala Gly 
        115                 120                 125             


Trp Arg Thr Ser Leu Ser Glu Thr Ser Lys Ala Arg His Asp Asn Leu 
    130                 135                 140                 


Asp Gly Asp Val Leu Gly Asn Phe Val Ser Ser Lys Arg Pro Pro His 
145                 150                 155                 160 


Lys Ser Lys Pro Met Gln Thr Val Pro Gly Glu Thr Pro Val Leu Thr 
                165                 170                 175     


Ser Ala Trp Glu Lys Ile Asp Lys Leu His Ser Glu Pro Ser Leu Asp 
            180                 185                 190         


Val Lys Arg Met Gly Glu Asn Ser Arg Pro Lys Ser Gly Leu Ile Val 
        195                 200                 205             


Arg Gly Met Met Ser Gly Pro Ile Ala Ser Ser Pro Gln Asp Ser Phe 
    210                 215                 220                 


His Arg His Tyr Leu Arg Arg Ser Ser Pro Ser Ser Ser Ser Thr Gln 
225                 230                 235                 240 


Pro Gln Glu Glu Ser Arg Lys Val Pro Glu Leu Phe Val Cys Thr Gln 
                245                 250                 255     


Gln Asp Ile Leu Ala Ser Ser Asn Ser Ser Pro Ser Arg Thr Ser Leu 
            260                 265                 270         


Gly Gln Leu Ser Glu Leu Thr Val Glu Arg Gln Lys Thr Thr Ala Ser 
        275                 280                 285             


Ser Pro Pro His Leu Pro Ser Lys Arg Leu Pro Pro Trp Asp Arg Ala 
    290                 295                 300                 


Arg Pro Arg Asp Pro Ser Glu Asp Thr Pro Ala Val Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Thr Asp Arg Met Pro Leu Lys Leu Tyr Leu Pro Gly Gly Asn Ser 
                325                 330                 335     


Arg Met Thr Gln Glu Arg Leu Glu Arg Ala Phe Lys Arg Gln Gly Ser 
            340                 345                 350         


Gln Pro Ala Pro Val Arg Lys Asn Gln Leu Leu Pro Ser Asp Lys Val 
        355                 360                 365             


Asp Gly Glu Leu Gly Ala Leu Arg Leu Glu Asp Val Glu Asp Glu Leu 
    370                 375                 380                 


Ile Arg Glu Glu Val Ile Leu Ser Pro Val Pro Ser Val Leu Lys Leu 
385                 390                 395                 400 


Gln Thr Ala Ser Lys Pro Ile Asp Leu Ser Val Ala Lys Glu Ile Lys 
                405                 410                 415     


Thr Leu Leu Phe Gly Ser Ser Phe Cys Cys Phe Asn Glu Glu Trp Lys 
            420                 425                 430         


Leu Gln Ser Phe Ser Phe Ser Asn Thr Ala Ser Leu Lys Tyr Gly Ile 
        435                 440                 445             


Val Gln Asn Lys Gly Gly Pro Cys Gly Val Leu Ala Ala Val Gln Gly 
    450                 455                 460                 


Cys Val Leu Gln Lys Leu Leu Phe Glu Gly Asp Ser Lys Ala Asp Cys 
465                 470                 475                 480 


Ala Gln Gly Leu Gln Pro Ser Asp Ala His Arg Thr Arg Cys Leu Val 
                485                 490                 495     


Leu Ala Leu Ala Asp Ile Val Trp Arg Ala Gly Gly Arg Glu Arg Ala 
            500                 505                 510         


Val Val Ala Leu Ala Ser Arg Thr Gln Gln Phe Ser Pro Thr Gly Lys 
        515                 520                 525             


Tyr Lys Ala Asp Gly Val Leu Glu Thr Leu Thr Leu His Ser Leu Thr 
    530                 535                 540                 


Cys Tyr Glu Asp Leu Val Thr Phe Leu Gln Gln Ser Ile His Gln Phe 
545                 550                 555                 560 


Glu Val Gly Pro Tyr Gly Cys Ile Leu Leu Thr Leu Ser Ala Ile Leu 
                565                 570                 575     


Ser Arg Ser Thr Glu Leu Ile Arg Gln Asp Phe Asp Val Pro Thr Ser 
            580                 585                 590         


His Leu Ile Gly Ala His Gly Tyr Cys Thr Gln Glu Leu Val Asn Leu 
        595                 600                 605             


Leu Leu Thr Gly Lys Ala Val Ser Asn Val Phe Asn Asp Val Val Glu 
    610                 615                 620                 


Leu Asp Ser Gly Asp Gly Asn Ile Thr Leu Leu Arg Gly Ile Ala Ala 
625                 630                 635                 640 


Arg Ser Asp Ile Gly Phe Leu Ser Leu Phe Glu His Tyr Asn Met Cys 
                645                 650                 655     


Gln Val Gly Cys Phe Leu Lys Thr Pro Arg Phe Pro Ile Trp Val Val 
            660                 665                 670         


Cys Ser Glu Ser His Phe Ser Ile Leu Phe Ser Leu Gln Pro Gly Leu 
        675                 680                 685             


Leu Arg Asp Trp Arg Thr Glu Arg Leu Phe Asp Leu Tyr Tyr Tyr Asp 
    690                 695                 700                 


Gly Leu Ala Asn Gln Gln Glu Gln Ile Arg Leu Thr Ile Asp Thr Thr 
705                 710                 715                 720 


Gln Thr Ile Ser Glu Asp Thr Asp Asn Asp Leu Val Pro Pro Leu Glu 
                725                 730                 735     


Leu Cys Ile Arg Thr Lys Trp Lys Gly Ala Ser Val Asn Trp Asn Gly 
            740                 745                 750         


Ser Asp Pro Ile Leu 
        755         


<210>  3828
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM189B__Homo_sapiens__NP_001254537

<400>  3828

Met Met Pro Ser Pro Ser Asp Ser Ser Arg Ser Leu Thr Ser Arg Pro 
1               5                   10                  15      


Ser Thr Arg Gly Leu Thr His Leu Arg Leu His Arg Pro Trp Leu Gln 
            20                  25                  30          


Ala Leu Leu Thr Leu Gly Leu Val Gln Val Leu Leu Gly Ile Leu Val 
        35                  40                  45              


Val Thr Phe Ser Met Val Ala Ser Ser Val Thr Thr Thr Glu Ser Ile 
    50                  55                  60                  


Lys Arg Ser Cys Pro Ser Trp Ala Gly Phe Ser Ile Ser Phe Phe Ser 
65                  70                  75                  80  


Leu Leu Ser Val Leu Cys Val Met Leu Ser Met Ala Gly Ser Val Leu 
                85                  90                  95      


Ser Cys Lys Asn Ala Gln Leu Ala Arg Asp Phe Gln Gln Cys Ser Leu 
            100                 105                 110         


Glu Gly Lys Val Cys Val Cys Cys Pro Ser Val Pro Leu Leu Arg Pro 
        115                 120                 125             


Cys Pro Glu Ser Gly Gln Glu Leu Lys Val Ala Pro Asn Ser Thr Cys 
    130                 135                 140                 


Asp Glu Ala Arg Gly Ala Leu Lys Asn Leu Leu Phe Ser Val Cys Gly 
145                 150                 155                 160 


Leu Thr Ile Cys Ala Ala Ile Ile Cys Thr Leu Ser Ala Ile Val Cys 
                165                 170                 175     


Cys Ile Gln Ile Phe Ser Leu Asp Leu Val His Thr Gln Leu Ala Pro 
            180                 185                 190         


Glu Arg Ser Val Ser Gly Pro Leu Gly Pro Leu Gly Cys Thr Ser Pro 
        195                 200                 205             


Pro Pro Ala Pro Leu Leu His Thr Met Leu Asp Leu Glu Glu Phe Val 
    210                 215                 220                 


Pro Pro Val Pro Pro Pro Pro Tyr Tyr Pro Pro Glu Tyr Thr Cys Ser 
225                 230                 235                 240 


Ser Glu Thr Asp Ala Gln Ser Ile Thr Tyr Asn Gly Ser Met Asp Ser 
                245                 250                 255     


Pro Val Pro Leu Tyr Pro Thr Asp Cys Pro Pro Ser Tyr Glu Ala Val 
            260                 265                 270         


Met Gly Leu Arg Gly Asp Ser Gln Ala Thr Leu Phe Asp Pro Gln Leu 
        275                 280                 285             


His Asp Gly Ser Cys Ile Cys Glu Arg Val Ala Ser Ile Val Asp Val 
    290                 295                 300                 


Ser Met Asp Ser Gly Ser Leu Val Leu Ser Ala Ile Gly Asp Leu Pro 
305                 310                 315                 320 


Gly Gly Ser Ser Pro Ser Glu Asp Ser Cys Leu Leu Glu Leu Gln Gly 
                325                 330                 335     


Ser Val Arg Ser Val Asp Tyr Val Leu Phe Arg Ser Ile Gln Arg Ser 
            340                 345                 350         


Arg Ala Gly Tyr Cys Leu Ser Leu Asp Cys Gly Leu Arg Gly Pro Phe 
        355                 360                 365             


Glu Glu Ser Pro Leu Pro Arg Arg Pro Pro Arg Ala Ala Arg Ser Tyr 
    370                 375                 380                 


Ser Cys Ser Ala Pro Glu Ala Pro Pro Pro Leu Gly Ala Pro Thr Ala 
385                 390                 395                 400 


Ala Arg Ser Cys His Arg Leu Glu Gly Trp Pro Pro Trp Val Gly Pro 
                405                 410                 415     


Cys Phe Pro Glu Leu Arg Arg Arg Val Pro Arg Gly Gly Gly Arg Pro 
            420                 425                 430         


Ala Ala Ala Pro Pro Thr Arg Ala Pro Thr Arg Arg Phe Ser Asp Ser 
        435                 440                 445             


Ser Gly Ser Leu Thr Pro Pro Gly His Arg Pro Pro His Pro Ala Ser 
    450                 455                 460                 


Pro Pro Pro Leu Leu Leu Pro Arg Ser His Ser Asp Pro Gly Ile Thr 
465                 470                 475                 480 


Thr Ser Ser Asp Thr Ala Asp Phe Arg Asp Leu Tyr Thr Lys Val Leu 
                485                 490                 495     


Glu Glu Glu Ala Ala Ser Val Ser Ser Ala Asp Thr Gly Leu Cys Ser 
            500                 505                 510         


Glu Ala Cys Leu Phe Arg Leu Ala Arg Cys Pro Ser Pro Lys Leu Leu 
        515                 520                 525             


Arg Ala Arg Ser Ala Glu Lys Arg Arg Pro Val Pro Thr Phe Gln Lys 
    530                 535                 540                 


Val Pro Leu Pro Ser Gly Pro Ala Pro Ala His Ser Leu Gly Asp Leu 
545                 550                 555                 560 


Lys Gly Ser Trp Pro Gly Arg Gly Leu Val Thr Arg Phe Leu Gln Ile 
                565                 570                 575     


Ser Arg Lys Ala Pro Asp Pro Ser Gly Thr Gly Ala His Gly His Lys 
            580                 585                 590         


Gln Val Pro Arg Ser Leu Trp Gly Arg Pro Gly Arg Glu Ser Leu His 
        595                 600                 605             


Leu Arg Ser Cys Gly Asp Leu Ser Ser Ser Ser Ser Leu Arg Arg Leu 
    610                 615                 620                 


Leu Ser Gly Arg Arg Leu Glu Arg Gly Thr Arg Pro His Ser Leu Ser 
625                 630                 635                 640 


Leu Asn Gly Gly Ser Arg Glu Thr Gly Leu 
                645                 650 


<210>  3829
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM193B__Homo_sapiens__NP_001177875

<400>  3829

Met Thr Arg Arg Arg Ser Arg Pro Ser Gly Gly Ala Gly Arg Arg Glu 
1               5                   10                  15      


Arg Ala Arg Ala Ala Gly Pro Gln Lys Pro Gln Ala Pro Glu Pro Pro 
            20                  25                  30          


Pro Pro Pro Ser Leu Glu Ala Gly Ala Gly Ala Gly Pro Pro Glu Ala 
        35                  40                  45              


Pro Ala Glu Pro Asp His Asp Gly Pro Arg Glu Asp Asp Glu Pro Asn 
    50                  55                  60                  


Leu Val Pro Gly Pro Gln Val Pro Pro Ala Ser Ser Gln Pro Val Gln 
65                  70                  75                  80  


Thr Cys Cys Leu Leu Cys His Arg Glu Arg Lys Gly Trp Glu Glu Gly 
                85                  90                  95      


Pro Ser Gln Asn Gly Leu Val Leu Gln Gly Glu Lys Leu Pro Pro Asp 
            100                 105                 110         


Phe Met Pro Lys Leu Val Lys Asn Leu Leu Gly Glu Met Pro Leu Trp 
        115                 120                 125             


Val Cys Gln Ser Cys Arg Lys Ser Met Glu Glu Asp Glu Arg Gln Thr 
    130                 135                 140                 


Gly Arg Glu His Ala Val Ala Ile Ser Leu Ser His Thr Ser Cys Lys 
145                 150                 155                 160 


Ser Gln Ser Cys Gly Asp Asp Ser His Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Cys Pro Gly Asn Ser Gly Asp 
            180                 185                 190         


Trp Asp Pro Ser Ser Phe Leu Ser Ala His Lys Leu Ser Gly Leu Trp 
        195                 200                 205             


Asn Ser Pro His Ser Ser Gly Ala Met Pro Gly Ser Ser Leu Gly Ser 
    210                 215                 220                 


Pro Pro Thr Ile Pro Gly Glu Ala Phe Pro Val Ser Glu His His Gln 
225                 230                 235                 240 


His Ser Asp Leu Thr Ala Pro Pro Asn Ser Pro Thr Gly His His Pro 
                245                 250                 255     


Gln Pro Ala Ser Leu Ile Pro Ser His Pro Ser Ser Phe Gly Ser Pro 
            260                 265                 270         


Pro His Pro His Leu Leu Pro Thr Thr Pro Ala Ala Pro Phe Pro Ala 
        275                 280                 285             


Gln Ala Ser Glu Cys Pro Val Ala Ala Ala Thr Ala Pro His Thr Pro 
    290                 295                 300                 


Gly Pro Cys Gln Ser Ser His Leu Pro Ser Thr Ser Met Pro Leu Leu 
305                 310                 315                 320 


Lys Met Pro Pro Pro Phe Ser Gly Cys Ser His Pro Cys Ser Gly His 
                325                 330                 335     


Cys Gly Gly His Cys Ser Gly Pro Leu Leu Pro Pro Pro Ser Ser Gln 
            340                 345                 350         


Pro Leu Pro Ser Thr His Arg Asp Pro Gly Cys Lys Gly His Lys Phe 
        355                 360                 365             


Ala His Ser Gly Leu Ala Cys Gln Leu Pro Gln Pro Cys Glu Ala Asp 
    370                 375                 380                 


Glu Gly Leu Gly Glu Glu Glu Asp Ser Ser Ser Glu Arg Ser Ser Cys 
385                 390                 395                 400 


Thr Ser Ser Ser Thr His Gln Arg Asp Gly Lys Phe Cys Asp Cys Cys 
                405                 410                 415     


Tyr Cys Glu Phe Phe Gly His Asn Ala Glu Lys Glu Lys Ala Gln Leu 
            420                 425                 430         


Ala Ala Glu Ala Leu Lys Gln Ala Asn Arg Val Ser Gly Ser Arg Glu 
        435                 440                 445             


Pro Arg Pro Ala Arg Glu Arg Leu Leu Glu Trp Pro Asp Arg Glu Leu 
    450                 455                 460                 


Asp Arg Val Asn Ser Phe Leu Ser Ser Arg Leu Gln Glu Ile Lys Asn 
465                 470                 475                 480 


Thr Val Lys Asp Ser Ile Arg Ala Ser Phe Ser Val Cys Glu Leu Ser 
                485                 490                 495     


Met Asp Ser Asn Gly Phe Ser Lys Glu Gly Ala Ala Glu Pro Glu Pro 
            500                 505                 510         


Gln Ser Leu Pro Pro Ser Asn Leu Ser Gly Ser Ser Glu Gln Gln Pro 
        515                 520                 525             


Asp Ile Asn Leu Asp Leu Ser Pro Leu Thr Leu Gly Ser Pro Gln Asn 
    530                 535                 540                 


His Thr Leu Gln Ala Pro Gly Glu Pro Ala Pro Pro Trp Ala Glu Met 
545                 550                 555                 560 


Arg Gly Pro His Pro Pro Trp Thr Glu Val Arg Gly Pro Pro Pro Gly 
                565                 570                 575     


Ile Val Pro Glu Asn Gly Leu Val Arg Arg Leu Asn Thr Val Pro Asn 
            580                 585                 590         


Leu Ser Arg Val Ile Trp Val Lys Thr Pro Lys Pro Gly Tyr Pro Ser 
        595                 600                 605             


Ser Glu Glu Pro Ser Ser Lys Glu Val Pro Ser Cys Lys Gln Glu Leu 
    610                 615                 620                 


Pro Glu Pro Val Ser Ser Gly Gly Lys Pro Gln Lys Gly Lys Arg Gln 
625                 630                 635                 640 


Gly Ser Gln Ala Lys Lys Ser Glu Ala Ser Pro Ala Pro Arg Pro Pro 
                645                 650                 655     


Ala Ser Leu Glu Val Pro Ser Ala Lys Gly Gln Val Ala Gly Pro Lys 
            660                 665                 670         


Gln Pro Gly Arg Val Leu Glu Leu Pro Lys Val Gly Ser Cys Ala Glu 
        675                 680                 685             


Ala Gly Glu Gly Ser Arg Gly Ser Arg Pro Gly Pro Gly Trp Ala Gly 
    690                 695                 700                 


Ser Pro Lys Thr Glu Lys Glu Lys Gly Ser Ser Trp Arg Asn Trp Pro 
705                 710                 715                 720 


Gly Glu Ala Lys Ala Arg Pro Gln Glu Gln Glu Ser Val Gln Pro Ser 
                725                 730                 735     


Gly Pro Ala Arg Pro Gln Ser Leu Pro Gln Gly Lys Gly Arg Ser Arg 
            740                 745                 750         


Arg Ser Arg Asn Lys Gln Glu Lys Pro Ala Ser Ser Leu Asp Asp Val 
        755                 760                 765             


Phe Leu Pro Lys Asp Met Asp Gly Val Glu Met Asp Glu Thr Asp Arg 
    770                 775                 780                 


Glu Val Glu Tyr Phe Lys Arg Phe Cys Leu Asp Ser Ala Lys Gln Thr 
785                 790                 795                 800 


Arg Gln Lys Val Ala Val Asn Trp Thr Asn Phe Ser Leu Lys Lys Thr 
                805                 810                 815     


Thr Pro Ser Thr Ala Gln 
            820         


<210>  3830
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM196A__Homo_sapiens__NP_001034851

<400>  3830

Met Val Ser Lys Asp Thr Gly Lys Cys Ile Leu Thr Thr Ser Glu Ser 
1               5                   10                  15      


Glu Val Glu Pro Ala Ala Cys Leu Ala Leu Glu Met Lys Tyr Ala Leu 
            20                  25                  30          


Asp Pro Asn Arg Gln Ile Lys Lys Arg Asn Lys Ala Leu Gln Val Arg 
        35                  40                  45              


Phe Lys Asp Ile Cys Glu Ala Gln Asn Glu Gln Arg Asp Thr Gln Leu 
    50                  55                  60                  


Ser Ser Gly Gln Leu Gly Glu Lys Arg Glu Ala Lys Pro Val Ser Cys 
65                  70                  75                  80  


Arg Ala Ala Tyr Arg Lys Tyr Met Thr Val Pro Ala Arg Arg Ser Ile 
                85                  90                  95      


Pro Asn Val Thr Lys Ser Thr Gly Val Gln Thr Ser Pro Asp Leu Lys 
            100                 105                 110         


Lys Cys Tyr Gln Thr Phe Pro Leu Asp Arg Lys Lys Gly Asn Leu Lys 
        115                 120                 125             


Ser Leu Pro Ala Ala Asp Pro Phe Lys Ser Gln Asn Asn Gly Phe Leu 
    130                 135                 140                 


Thr Asp Ala Lys Glu Lys Asn Glu Ala Gly Pro Met Glu Glu Ala Arg 
145                 150                 155                 160 


Pro Cys Gly Ala Gly Arg Val His Lys Thr Thr Ala Leu Val Phe His 
                165                 170                 175     


Ser Asn Gln His Met Asn Thr Val Asp Gln Pro Leu Gly Val Asn Cys 
            180                 185                 190         


Thr Glu Pro Cys Lys Ser Pro Glu Pro Leu Ser Tyr Gly Glu Ala Ala 
        195                 200                 205             


Leu Gln Asn Ser Thr Arg Pro Pro Ser Glu Glu Pro Asp Tyr Gln Leu 
    210                 215                 220                 


Leu Gly Arg Ala Lys Gln Asp Arg Gly Arg Pro Asn Ser Glu Glu Pro 
225                 230                 235                 240 


Ala Pro Pro Ala Leu Arg Arg Val Phe Lys Thr Glu Val Ala Thr Val 
                245                 250                 255     


Tyr Ala Pro Ala Leu Ser Ala Arg Ala Pro Glu Pro Gly Leu Ser Asp 
            260                 265                 270         


Ser Ala Ala Ala Ser Gln Trp Ser Leu Cys Pro Ala Asp Asp Glu Arg 
        275                 280                 285             


Arg Arg Ala Thr His Leu Asn Gly Leu Gln Ala Pro Ser Glu Thr Ala 
    290                 295                 300                 


Leu Ala Cys Ser Pro Pro Met Gln Cys Leu Ser Pro Glu Cys Ser Glu 
305                 310                 315                 320 


Gln Pro Ser Gln Thr His Thr Pro Pro Gly Leu Gly Asn Gln Pro Ser 
                325                 330                 335     


Pro Thr Ala Val Ala Ala Gly Glu Glu Cys Gln Arg Ile Val Pro His 
            340                 345                 350         


Thr Glu Val Val Asp Leu Lys Ala Gln Leu Gln Met Met Glu Asn Leu 
        355                 360                 365             


Ile Ser Ser Ser Gln Glu Thr Ile Lys Val Leu Leu Gly Val Ile Gln 
    370                 375                 380                 


Glu Leu Glu Lys Gly Glu Ala His Arg Glu Gly Leu Ser Tyr Arg Thr 
385                 390                 395                 400 


Gly Gln Asp Thr Ala Asn Cys Asp Thr Cys Arg Asn Ser Ala Cys Ile 
                405                 410                 415     


Ile Tyr Ser Val Glu Leu Asp Phe Lys Gln Gln Glu Asp Lys Leu Gln 
            420                 425                 430         


Pro Val Leu Arg Lys Leu His Pro Ile Glu Glu Thr Gln Val Ile Pro 
        435                 440                 445             


Ser Pro Tyr Ser Gln Glu Thr Tyr Ser Ser Thr Pro Lys Gln Lys Ser 
    450                 455                 460                 


Lys Thr Glu Ser Lys Lys His Gly Arg Trp Lys Leu Trp Phe Leu 
465                 470                 475                 


<210>  3831
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM196B__Homo_sapiens__NP_001123363

<400>  3831

Met Ala Gln Gln Asn Met Lys Val Arg Pro Val Leu Leu Lys Arg Asn 
1               5                   10                  15      


Ser Leu Glu Ser Val Glu Phe Val Lys Gln Pro His His Arg Arg Ser 
            20                  25                  30          


Lys Ser Gln Gln Val Arg Phe Lys Glu Asp Gly Thr Thr Lys Asn Pro 
        35                  40                  45              


Thr Gly Leu Ala Glu Val Asp Val Gln Thr Pro Glu Asp Pro Ala Val 
    50                  55                  60                  


Met Gly Lys Thr Gln Ala Thr Arg His His Leu Pro Pro Thr Tyr Ser 
65                  70                  75                  80  


Leu Ser Phe Pro Arg Ser Gln Lys Ala Gly Gly Phe Arg Asn Ile Ala 
                85                  90                  95      


Ile Gln Thr Ser Pro Ser Leu Arg Lys His Phe Pro Val Phe Lys Arg 
            100                 105                 110         


Lys Arg Leu Thr Ala Ser Lys Ser Leu Val Glu Met Pro Thr Ala Ser 
        115                 120                 125             


Gln Ser Ala Ile Gln Val Asn Gly Asn Leu Ser Glu Gln Asp Ile Val 
    130                 135                 140                 


Ser Ser Asp Leu Ala Tyr Leu Arg Leu Ala Gln His Leu Glu Asp Gly 
145                 150                 155                 160 


Pro Arg Arg Val Lys Val Ser His Ala Phe Leu Pro Arg Val Pro Lys 
                165                 170                 175     


Val Gln Ser Asn Gly Pro Val Ser Ile Cys Leu Glu Ala Gly Thr Trp 
            180                 185                 190         


Arg Ser Leu Glu Lys Ala Thr Ala Ala Ile Gln Val Pro Asp Asp Ile 
        195                 200                 205             


Tyr His Ser Pro Ser Trp Glu Ala Arg Glu Ser Ala Leu Ser Pro Asp 
    210                 215                 220                 


Arg Ser Ala Glu Val Ser Asn Ser Ile His Pro Leu Asp Asp Thr Arg 
225                 230                 235                 240 


Pro Gly Asp Gly Arg Arg Val Thr Pro Leu Asp Ser Glu Lys Ser Thr 
                245                 250                 255     


Ser Cys Leu Asn Ala Thr Ser Val Ala Ser His Thr Pro Gly Thr Glu 
            260                 265                 270         


Glu Leu Lys Pro Glu Leu Leu Leu Pro Lys Asp Asn Ser Asp Asp Lys 
        275                 280                 285             


Asp Leu Gly Ser Leu Ser Ser Gln Ser Lys Glu Thr Cys Val Pro Ser 
    290                 295                 300                 


Ser Pro Arg Thr His Ser Ser Pro Ser Gln Gly Ser His Ser Gln Pro 
305                 310                 315                 320 


Ala His Pro Gly Arg Ala Ser Asp Cys Pro Ser Ser Ser Asn Asn His 
                325                 330                 335     


Gln Asn Leu Val Ser Leu Lys Thr Asn Ser Ala Ser Lys Ser Ala Pro 
            340                 345                 350         


Gly Cys Gln Glu Gln Thr Ala Asn Asn Pro Thr Glu Ser Asp Thr Leu 
        355                 360                 365             


Glu Phe Pro Asn Cys Pro Gly Ser Asn His Leu Pro Ser Ser Leu Ser 
    370                 375                 380                 


Arg Ser Glu Thr Lys Leu Gln Ser Asn Arg Glu Ile Ser Asp Ile Asn 
385                 390                 395                 400 


Gln Ile His Leu Ala Arg Gly Glu Leu Cys Asp Leu Gln Gly Arg Leu 
                405                 410                 415     


Gln Ser Val Glu Glu Ser Leu His Ser Asn Gln Glu Lys Ile Lys Val 
            420                 425                 430         


Leu Leu Asn Val Ile Gln Asp Leu Glu Lys Ala Arg Ala Leu Thr Glu 
        435                 440                 445             


Gly Arg Asn Phe Tyr Arg Thr Gly Gln Asp Leu Asn Asn Cys Ser Thr 
    450                 455                 460                 


Cys Gln Asn Thr Ala Cys Ile Ile Tyr Ser Val Glu Tyr Asp Phe Arg 
465                 470                 475                 480 


Gln Gln Glu Gly Arg Phe His Glu Val Leu Gln Ser Leu Glu Glu Ala 
                485                 490                 495     


Glu Pro Val Glu Glu Ala Ser Pro Pro Pro Lys Ser Pro Ala Glu Pro 
            500                 505                 510         


Pro Ala Pro Glu Lys Gln Asp Leu Arg Arg Lys Thr Lys Lys Val Lys 
        515                 520                 525             


Lys Lys Cys Phe Trp Trp Ile 
    530                 535 


<210>  3832
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM198B__Homo_sapiens__NP_001026870

<400>  3832

Met Thr Cys Pro Asp Lys Pro Gly Gln Leu Ile Asn Trp Phe Ile Cys 
1               5                   10                  15      


Ser Leu Cys Val Pro Arg Val Arg Lys Leu Trp Ser Ser Arg Arg Pro 
            20                  25                  30          


Arg Thr Arg Arg Asn Leu Leu Leu Gly Thr Ala Cys Ala Ile Tyr Leu 
        35                  40                  45              


Gly Phe Leu Val Ser Gln Val Gly Arg Ala Ser Leu Gln His Gly Gln 
    50                  55                  60                  


Ala Ala Glu Lys Gly Pro His Arg Ser Arg Asp Thr Ala Glu Pro Ser 
65                  70                  75                  80  


Phe Pro Glu Ile Pro Leu Asp Gly Thr Leu Ala Pro Pro Glu Ser Gln 
                85                  90                  95      


Gly Asn Gly Ser Thr Leu Gln Pro Asn Val Val Tyr Ile Thr Leu Arg 
            100                 105                 110         


Ser Lys Arg Ser Lys Pro Ala Asn Ile Arg Gly Thr Val Lys Pro Lys 
        115                 120                 125             


Arg Arg Lys Lys His Ala Val Ala Ser Ala Ala Pro Gly Gln Glu Ala 
    130                 135                 140                 


Leu Val Gly Pro Ser Leu Gln Pro Gln Glu Ala Ala Arg Glu Ala Asp 
145                 150                 155                 160 


Ala Val Ala Pro Gly Tyr Ala Gln Gly Ala Asn Leu Val Lys Ile Gly 
                165                 170                 175     


Glu Arg Pro Trp Arg Leu Val Arg Gly Pro Gly Val Arg Ala Gly Gly 
            180                 185                 190         


Pro Asp Phe Leu Gln Pro Ser Ser Arg Glu Ser Asn Ile Arg Ile Tyr 
        195                 200                 205             


Ser Glu Ser Ala Pro Ser Trp Leu Ser Lys Asp Asp Ile Arg Arg Met 
    210                 215                 220                 


Arg Leu Leu Ala Asp Ser Ala Val Ala Gly Leu Arg Pro Val Ser Ser 
225                 230                 235                 240 


Arg Ser Gly Ala Arg Leu Leu Val Leu Glu Gly Gly Ala Pro Gly Ala 
                245                 250                 255     


Val Leu Arg Cys Gly Pro Ser Pro Cys Gly Leu Leu Lys Gln Pro Leu 
            260                 265                 270         


Asp Met Ser Glu Val Phe Ala Phe His Leu Asp Arg Ile Leu Gly Leu 
        275                 280                 285             


Asn Arg Thr Leu Pro Ser Val Ser Arg Lys Ala Glu Phe Ile Gln Ala 
    290                 295                 300                 


Ala Ala Ala Ala Cys Leu Ser Met Arg Leu Ala Phe Phe Ile Phe Pro 
305                 310                 315                 320 


Ala Trp Glu Asp Met Arg Val Pro Gly Lys Cys Cys Ile Gly His Ala 
                325                 330                 335     


Arg Leu Thr Trp Gly Thr Tyr Gln Gln Leu Leu Lys Gln Lys Cys Trp 
            340                 345                 350         


Gln Asn Gly Arg Val Pro Lys Pro Glu Ser Gly Cys Thr Glu Ile His 
        355                 360                 365             


His His Glu Trp Ser Lys Met Ala Leu Phe Asp Phe Leu Leu Gln Ile 
    370                 375                 380                 


Tyr Asn Arg Leu Asp Thr Asn Cys Cys Gly Phe Arg Pro Arg Lys Glu 
385                 390                 395                 400 


Asp Ala Cys Val Gln Asn Gly Leu Arg Pro Lys Cys Asp Asp Gln Gly 
                405                 410                 415     


Ser Ala Ala Leu Ala His Ile Ile Gln Arg Lys His Asp Pro Arg His 
            420                 425                 430         


Leu Val Phe Ile Asp Asn Lys Gly Phe Phe Asp Arg Ser Glu Asp Asn 
        435                 440                 445             


Leu Asn Phe Lys Leu Leu Glu Gly Ile Lys Glu Phe Pro Ala Ser Ala 
    450                 455                 460                 


Val Ser Val Leu Lys Ser Gln His Leu Arg Gln Lys Leu Leu Gln Ser 
465                 470                 475                 480 


Leu Phe Leu Asp Lys Val Tyr Trp Glu Ser Gln Gly Gly Arg Gln Gly 
                485                 490                 495     


Ile Glu Lys Leu Ile Asp Val Ile Glu His Arg Ala Lys Ile Leu Ile 
            500                 505                 510         


Thr Tyr Ile Asn Ala His Gly Val Lys Val Leu Pro Met Asn Glu 
        515                 520                 525         


<210>  3833
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM19A1__Homo_sapiens__NP_998774

<400>  3833

Met Ala Met Val Ser Ala Met Ser Trp Val Leu Tyr Leu Trp Ile Ser 
1               5                   10                  15      


Ala Cys Ala Met Leu Leu Cys His Gly Ser Leu Gln His Thr Phe Gln 
            20                  25                  30          


Gln His His Leu His Arg Pro Glu Gly Gly Thr Cys Glu Val Ile Ala 
        35                  40                  45              


Ala His Arg Cys Cys Asn Lys Asn Arg Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Leu Pro Gly Lys Val Ala Gly Thr Thr Arg Asn 
65                  70                  75                  80  


Arg Pro Ser Cys Val Asp Ala Ser Ile Val Ile Gly Lys Trp Trp Cys 
                85                  90                  95      


Glu Met Glu Pro Cys Leu Glu Gly Glu Glu Cys Lys Thr Leu Pro Asp 
            100                 105                 110         


Asn Ser Gly Trp Met Cys Ala Thr Gly Asn Lys Ile Lys Thr Thr Arg 
        115                 120                 125             


Ile His Pro Arg Thr 
    130             


<210>  3834
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM19A2__Homo_sapiens__NP_848634

<400>  3834

Met Ser Lys Arg Tyr Leu Gln Lys Ala Thr Lys Gly Lys Leu Leu Ile 
1               5                   10                  15      


Ile Ile Phe Ile Val Thr Leu Trp Gly Lys Val Val Ser Ser Ala Asn 
            20                  25                  30          


His His Lys Ala His His Val Lys Thr Gly Thr Cys Glu Val Val Ala 
        35                  40                  45              


Leu His Arg Cys Cys Asn Lys Asn Lys Ile Glu Glu Arg Ser Gln Thr 
    50                  55                  60                  


Val Lys Cys Ser Cys Phe Pro Gly Gln Val Ala Gly Thr Thr Arg Ala 
65                  70                  75                  80  


Ala Pro Ser Cys Val Asp Ala Ser Ile Val Glu Gln Lys Trp Trp Cys 
                85                  90                  95      


His Met Gln Pro Cys Leu Glu Gly Glu Glu Cys Lys Val Leu Pro Asp 
            100                 105                 110         


Arg Lys Gly Trp Ser Cys Ser Ser Gly Asn Lys Val Lys Thr Thr Arg 
        115                 120                 125             


Val Thr His 
    130     


<210>  3835
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM19A4__Homo_sapiens__NP_001005527

<400>  3835

Met Arg Ser Pro Arg Met Arg Val Cys Ala Lys Ser Val Leu Leu Ser 
1               5                   10                  15      


His Trp Leu Phe Leu Ala Tyr Val Leu Met Val Cys Cys Lys Leu Met 
            20                  25                  30          


Ser Ala Ser Ser Gln His Leu Arg Gly His Ala Gly His His Gln Ile 
        35                  40                  45              


Lys Gln Gly Thr Cys Glu Val Val Ala Val His Arg Cys Cys Asn Lys 
    50                  55                  60                  


Asn Arg Ile Glu Glu Arg Ser Gln Thr Val Lys Cys Ser Cys Phe Pro 
65                  70                  75                  80  


Gly Gln Val Ala Gly Thr Thr Arg Ala Gln Pro Ser Cys Val Glu Ala 
                85                  90                  95      


Ser Ile Val Ile Gln Lys Trp Trp Cys His Met Asn Pro Cys Leu Glu 
            100                 105                 110         


Gly Glu Asp Cys Lys Val Leu Pro Asp Tyr Ser Gly Trp Ser Cys Ser 
        115                 120                 125             


Ser Gly Asn Lys Val Lys Thr Thr Lys Val Thr Arg 
    130                 135                 140 


<210>  3836
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM19A5__Homo_sapiens__NP_001076436

<400>  3836

Met Ala Pro Ser Pro Arg Thr Gly Ser Arg Gln Asp Ala Thr Ala Leu 
1               5                   10                  15      


Pro Ser Met Ser Ser Thr Phe Trp Ala Phe Met Ile Leu Ala Ser Leu 
            20                  25                  30          


Leu Ile Ala Tyr Cys Ser Gln Leu Ala Ala Gly Thr Cys Glu Ile Val 
        35                  40                  45              


Thr Leu Asp Arg Asp Ser Ser Gln Pro Arg Arg Thr Ile Ala Arg Gln 
    50                  55                  60                  


Thr Ala Arg Cys Ala Cys Arg Lys Gly Gln Ile Ala Gly Thr Thr Arg 
65                  70                  75                  80  


Ala Arg Pro Ala Cys Val Asp Ala Arg Ile Ile Lys Thr Lys Gln Trp 
                85                  90                  95      


Cys Asp Met Leu Pro Cys Leu Glu Gly Glu Gly Cys Asp Leu Leu Ile 
            100                 105                 110         


Asn Arg Ser Gly Trp Thr Cys Thr Gln Pro Gly Gly Arg Ile Lys Thr 
        115                 120                 125             


Thr Thr Val Ser 
    130         


<210>  3837
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM204A__Homo_sapiens__NP_071346

<400>  3837

Met Trp Ser Gly Leu Leu Pro Pro Gly Leu Asn Glu Ser Asp Ala Glu 
1               5                   10                  15      


Ser Asn Ser Glu Asp Glu Ala Thr Leu Glu Asn Ser Gly Leu Asn Leu 
            20                  25                  30          


Gln Glu Asp Lys Glu Asp Glu Ser Ile Arg Lys Thr Glu Ile Ile Asp 
        35                  40                  45              


Phe Ser Thr Asp Glu Pro Lys Thr Glu Thr Glu Ser Asn Val Asn Ala 
    50                  55                  60                  


Tyr Glu Glu Cys Pro Ser Gly Ile Pro Ile Asp Met Trp Asn Lys Phe 
65                  70                  75                  80  


Gln Glu Leu His Lys Lys His Ser Glu Gln Lys Ser Thr Thr Ser Arg 
                85                  90                  95      


Phe Arg Gly Lys Arg Arg Lys Arg Ser Arg Lys Asp Lys Leu Lys Asn 
            100                 105                 110         


Glu Lys Glu Leu His Ser Glu Pro Ser Ser Asn Glu Thr Gln Trp Lys 
        115                 120                 125             


Glu Leu Thr Gln Tyr Phe Gly Val Asn Asp Arg Phe Asp Pro Pro Val 
    130                 135                 140                 


Lys Arg Lys Lys Val Glu Lys Ser Gly Leu Glu Lys Arg Ile Asp Gln 
145                 150                 155                 160 


Ala Val Glu Glu Trp Asn Ile Glu Lys Ala Glu Glu Leu Ser Asn Gln 
                165                 170                 175     


Leu Ala Thr Arg Glu Leu Gly Val Lys Ile Ala Lys Ala Val Ala Cys 
            180                 185                 190         


His Asn Phe Val Lys Ala Lys Lys Glu Val Glu Asn Ser Gln Ala Ala 
        195                 200                 205             


Arg Lys Lys Lys Lys Leu Ala Trp Gly Phe Glu Ala Lys Lys Arg Trp 
    210                 215                 220                 


Glu Thr Lys Ser Asn Met Gly Tyr Met 
225                 230             


<210>  3838
<211>  1335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM205A__Homo_sapiens__NP_001135389

<400>  3838

Met Leu Ser Pro Thr Phe Val Leu Trp Glu Val Gly Tyr Pro Leu Tyr 
1               5                   10                  15      


Ile Tyr Gly Ser Ile Phe Ile Val Ile Val Ile Ile Trp Gln Val Lys 
            20                  25                  30          


Arg Ser His His Glu Leu Ser Ser Glu Pro Lys Arg Ser Cys Cys Arg 
        35                  40                  45              


Cys His Gln Lys Val Arg Gln Arg Ala Arg Asp Ala Ala Ser Thr Ala 
    50                  55                  60                  


Arg Arg Arg Ser Arg Glu Glu Ala Glu Lys Pro Gln Lys Leu Leu Ser 
65                  70                  75                  80  


Ile Ile Lys Ser Gln Gly Trp Leu Pro Leu Glu Arg Ser Val Arg Arg 
                85                  90                  95      


Ile Leu Cys Ala Asp Pro Cys Cys Gln Ile Cys Asn Ser Val Ala Leu 
            100                 105                 110         


Glu Ile Gln Gln Leu Leu Val Gly Glu Asn Asn Gln Ile Ser Leu Thr 
        115                 120                 125             


Leu Ser Gly Pro Leu Gln Gly Ser Ser Cys Leu Glu Met Leu Ser Thr 
    130                 135                 140                 


Ser Ser Met Ser Leu Asp Gln Ser Leu Glu Phe His Ser Trp His Thr 
145                 150                 155                 160 


Arg Glu Leu Ser Leu Ser Ser Val Thr Pro Thr Leu Ser Gln Leu Thr 
                165                 170                 175     


Asp Gln Lys Ser Leu Thr Gln Ser Ala Ala Gln Ser Thr Tyr Ala Asp 
            180                 185                 190         


Gly Ile Gln Asp Tyr Trp Ala Asp His Leu Gln Leu Gly Gln Glu Phe 
        195                 200                 205             


Gln Val Pro Asp Val Leu Arg Gly Pro Asn Thr Ile Ala Ser Ser Arg 
    210                 215                 220                 


Ile Glu Lys Pro Arg Ala Pro Leu Asn Gln Glu Glu Met Thr Gln Ser 
225                 230                 235                 240 


Asn Pro Ser Leu Val Gln Gly Asn Gln Gly Gln His His Leu Asn Ser 
                245                 250                 255     


Gln Val Ser Leu Leu Ser Leu Asn Pro Glu Thr Leu Asn Arg Met His 
            260                 265                 270         


Pro Met Ala Leu His Met Val Leu Pro Ala His Leu Pro Phe Leu Ser 
        275                 280                 285             


Pro Glu Val Leu Arg Leu Leu Glu Val His Val Lys Lys Trp Met His 
    290                 295                 300                 


Phe Gln Arg Trp Gly Leu Pro Arg Arg Val Glu Glu Ser Leu Arg Gln 
305                 310                 315                 320 


Leu Met Pro Asn Pro Pro Leu Tyr Tyr Gln Pro Gly Asn Asp Gln Pro 
                325                 330                 335     


Val Ser Phe Asn Leu Lys Asn Thr Pro Gln Val Ser Leu His Arg Phe 
            340                 345                 350         


Glu Thr Ile Ser Leu Gln Thr Trp Cys Ser Cys Val Ala Gly Gln Pro 
        355                 360                 365             


Ile Gln Thr Phe Trp Val Ser Glu Trp Ser Thr Met Asn Pro Glu Gln 
    370                 375                 380                 


Arg His His Cys Gln Gln Thr Pro Asn Pro Met Ala Leu Ala Leu Pro 
385                 390                 395                 400 


Ser Pro Ala Leu Lys Ala Leu Ser Gly Pro His Pro Gln Ser Gly Gly 
                405                 410                 415     


Gln Asp Asn Asp Ser Gly Ser Asp Leu Gln Gln Lys Tyr Ser Gln Leu 
            420                 425                 430         


Phe Cys Gly Leu Pro Ser Leu His Ser Glu Ser Leu Val Ala Thr Phe 
        435                 440                 445             


Met Gly Ser Gln Gly Leu Pro Lys Ile Glu Asn Val Pro Lys Pro Pro 
    450                 455                 460                 


Leu Lys Asp Pro Phe Leu Phe Asn Glu Leu Ser Phe Pro Gln Leu Leu 
465                 470                 475                 480 


Pro Lys Thr Ser Pro Gln Ser Ala Pro Pro Ser Ser Pro Leu Ser Pro 
                485                 490                 495     


Asn Trp Met Ser Pro Ser Asp His Gln Arg Ala Gln Ile Asn Val Pro 
            500                 505                 510         


Phe Leu Thr Leu Ala Glu Tyr Glu Ala Leu Glu Trp His Leu Leu Gln 
        515                 520                 525             


Arg Gln Leu Gln Leu Gln Trp Gly Trp Pro Ala Ala Leu Gln Arg Ser 
    530                 535                 540                 


Gln His Thr Gln Cys Leu Met Gln His Glu Pro Cys Gly Lys Ala Gln 
545                 550                 555                 560 


Ser Pro Glu Thr Thr Thr Ala Ser Gln Thr Gly Lys Ser Ile Ser Val 
                565                 570                 575     


Leu Thr Arg Glu Leu Leu Phe Phe Pro Glu His Ala Arg Lys Leu Leu 
            580                 585                 590         


Glu Phe His Ile Gln Lys Gln Leu Ile Arg His Arg Trp Gly Leu Pro 
        595                 600                 605             


Gln Lys Ile Gln Gln Ser Ile Gln Leu Leu Leu Thr Ser Thr Asp Gln 
    610                 615                 620                 


Gln Thr Val Ser Ser Ser Ser Thr Ala Leu Ala Asn Val Ser Ile Pro 
625                 630                 635                 640 


Gln Pro Val Ala Leu Glu Ala Asn Gly Ala Cys Asp Val Leu Ser Pro 
                645                 650                 655     


Ile Ala Ala Pro Val Ser Ile Pro Arg Pro His Leu Leu Thr Gln Val 
            660                 665                 670         


Lys Ala Ile Leu Gln Ser His Ile Asp Ser Lys Cys Gly Gln Ile His 
        675                 680                 685             


Gln Gly Lys Ile Pro Ala Cys Val His Arg Ser Trp Asp Cys Arg Ile 
    690                 695                 700                 


Ser Gly Val Leu Ala Val Ala Pro Phe Pro Cys Ile Pro Glu Ser Gln 
705                 710                 715                 720 


Phe Leu Glu Leu Gln Thr Ala Ser Asp Pro Asp Leu His His Lys Val 
                725                 730                 735     


Met Pro Trp Met Pro Thr Ala Leu Asp Gln Gln Gln Gln Ala Leu Pro 
            740                 745                 750         


Gly Thr Val Thr Glu His Pro Lys Leu Leu Arg Val Leu Ser Val Glu 
        755                 760                 765             


Ala Ile Glu Lys Leu Glu Thr Thr Leu Arg His Lys His Leu Ala Phe 
    770                 775                 780                 


Leu Ser Gly Leu Pro Ala Leu Tyr Tyr Val Ala Leu Pro Arg Ala Leu 
785                 790                 795                 800 


Ala Pro Ala Val Thr Ser Gln Ser Val Ile Thr Glu Met Glu Pro Ser 
                805                 810                 815     


Pro Val Glu Ile Pro Ala Glu Pro Leu Ile Gln Met Val Ser Phe Glu 
            820                 825                 830         


Glu Gln Cys Ile Ser Leu Gly Pro Cys Pro Gln Gly Asn Asn Glu Ser 
        835                 840                 845             


Cys Thr Asp Val Ala Lys Glu Phe Gln Pro Ala Val Pro Val Lys Gly 
    850                 855                 860                 


Thr Met Glu Thr Leu Pro Leu Glu Ser Gln Thr His Pro Thr Ser Pro 
865                 870                 875                 880 


His Ser Leu Gln Thr His Ile Leu Thr Lys Leu Asn Phe His Leu Arg 
                885                 890                 895     


Lys Lys Val Leu Glu Ile Gln Trp Gly Ile Pro Ile Arg Ala Arg Lys 
            900                 905                 910         


Ser Arg Glu Gln Thr Val Ala Ala Pro Glu Asn Ile Ser Thr Gln Lys 
        915                 920                 925             


Ser Leu Glu Ser Leu Asn His Gln Gly Glu Thr Leu Leu Gln Glu Leu 
    930                 935                 940                 


Pro Ile Pro Pro Asp Thr Leu Pro Ala Pro Asn Pro Glu Gly Val His 
945                 950                 955                 960 


Leu Lys Glu Gln Leu Ala Asn Asp Leu Lys Ala Val Gln Gln Asn Gln 
                965                 970                 975     


Lys Gln Ser Asn Ser Lys Ala Val Pro Gln Gly Ser Ala His Ser Val 
            980                 985                 990         


Ser Lys Ile Ser Gln Pro Ser Gly  Asp Met Thr Glu Ala  His Met Pro 
        995                 1000                 1005             


Cys Val  Gln Val Glu Ala Asn  Val Asn Lys Pro Ser  Leu Glu Glu 
    1010                 1015                 1020             


Pro Cys  Gly Pro Glu Pro Gln  Ser Pro Ser Lys Ser  Lys Asp Pro 
    1025                 1030                 1035             


Ala His  Val Pro Met Leu Ala  Gly Asn Arg Glu Asp  Pro Glu Glu 
    1040                 1045                 1050             


Thr Lys  Ala Ala Arg Asp His  Arg Glu Gly Asp Ala  Gly Phe Gly 
    1055                 1060                 1065             


Arg Ser  Ser Thr Arg Glu Glu  Arg Arg Pro Ala Glu  Asp Gln Arg 
    1070                 1075                 1080             


Pro Ala  Gly Met Leu Pro Asn  Lys Thr Pro Arg Gly  Ser Trp Arg 
    1085                 1090                 1095             


Trp Ser  Arg Ser Phe His Leu  Ala Asp Pro Cys Gln  His Ser Pro 
    1100                 1105                 1110             


Gln His  His Pro Gln Leu Lys  Leu Pro Gln Leu Pro  Pro Arg Val 
    1115                 1120                 1125             


Pro Gly  Glu Lys Glu Ser Glu  Lys Asp Leu Gln Asp  Ser Gln Thr 
    1130                 1135                 1140             


Lys Leu  Thr Val Ile Leu Glu  Pro Ala Thr Ile Pro  Glu Asn Ala 
    1145                 1150                 1155             


Gln Thr  Val Leu Pro Gln Ala  Ser Gln Gly Gln Pro  Phe Leu Ser 
    1160                 1165                 1170             


Gln Pro  Thr Gln Ala Lys Pro  Leu Gln Gly Gln Thr  Leu Gln Gly 
    1175                 1180                 1185             


Gln Val  Leu His Gly Leu Val  Met Pro Val His Ala  Gln Lys Lys 
    1190                 1195                 1200             


Pro Ser  Leu Thr Glu Ser Ser  Phe Arg Asn Lys Ile  Lys Cys Phe 
    1205                 1210                 1215             


Leu Gln  His Ile Asn Pro Lys  Thr Lys Gly Lys Gly  His Glu Asp 
    1220                 1225                 1230             


Ser Met  Phe Ser Ala Ala Ala  Lys Val Ala Lys Thr  Arg Lys Glu 
    1235                 1240                 1245             


Asn Val  Ala Lys Ser Leu Ala  Pro Ala Lys Ser Pro  Val Gly Arg 
    1250                 1255                 1260             


Ser Lys  Thr Glu Lys Pro Thr  Gly Cys Ser Lys Ala  Gln Ser Arg 
    1265                 1270                 1275             


Pro Ala  Gln Lys Leu Val Gly  Pro Ala Phe Leu Asp  Gly Pro Gln 
    1280                 1285                 1290             


Ser Leu  Asp Asp Lys Leu Arg  Leu His Ser Arg Gln  Pro Gly Ser 
    1295                 1300                 1305             


Ala Ser  Ala Leu Gly Tyr Pro  Arg His Cys Pro Arg  His Cys Pro 
    1310                 1315                 1320             


Arg Glu  Ala Cys Ala Asn Lys  Pro Gly His Pro Thr  
    1325                 1330                 1335 


<210>  3839
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM20A__Homo_sapiens__NP_001230675

<400>  3839

Met Tyr Arg Glu Gln Met Asn Leu Thr Ser Leu Asp Pro Pro Leu Gln 
1               5                   10                  15      


Leu Arg Leu Glu Ala Ser Trp Val Gln Phe His Leu Gly Ile Asn Arg 
            20                  25                  30          


His Gly Leu Tyr Ser Arg Ser Ser Pro Val Val Ser Lys Leu Leu Gln 
        35                  40                  45              


Asp Met Arg His Phe Pro Thr Ile Ser Ala Asp Tyr Ser Gln Asp Glu 
    50                  55                  60                  


Lys Ala Leu Leu Gly Ala Cys Asp Cys Thr Gln Ile Val Lys Pro Ser 
65                  70                  75                  80  


Gly Val His Leu Lys Leu Val Leu Arg Phe Ser Asp Phe Gly Lys Ala 
                85                  90                  95      


Met Phe Lys Pro Met Arg Gln Gln Arg Asp Glu Glu Thr Pro Val Asp 
            100                 105                 110         


Phe Phe Tyr Phe Ile Asp Phe Gln Arg His Asn Ala Glu Ile Ala Ala 
        115                 120                 125             


Phe His Leu Asp Arg Ile Leu Asp Phe Arg Arg Val Pro Pro Thr Val 
    130                 135                 140                 


Gly Arg Ile Val Asn Val Thr Lys Glu Ile Leu Glu Val Thr Lys Asn 
145                 150                 155                 160 


Glu Ile Leu Gln Ser Val Phe Phe Val Ser Pro Ala Ser Asn Val Cys 
                165                 170                 175     


Phe Phe Ala Lys Cys Pro Tyr Met Cys Lys Thr Glu Tyr Ala Val Cys 
            180                 185                 190         


Gly Asn Pro His Leu Leu Glu Gly Ser Leu Ser Ala Phe Leu Pro Ser 
        195                 200                 205             


Leu Asn Leu Ala Pro Arg Leu Ser Val Pro Asn Pro Trp Ile Arg Ser 
    210                 215                 220                 


Tyr Thr Leu Ala Gly Lys Glu Glu Trp Glu Val Asn Pro Leu Tyr Cys 
225                 230                 235                 240 


Asp Thr Val Lys Gln Ile Tyr Pro Tyr Asn Asn Ser Gln Arg Leu Leu 
                245                 250                 255     


Asn Val Ile Asp Met Ala Ile Phe Asp Phe Leu Ile Gly Asn Met Asp 
            260                 265                 270         


Arg His His Tyr Glu Met Phe Thr Lys Phe Gly Asp Asp Gly Phe Leu 
        275                 280                 285             


Ile His Leu Asp Asn Ala Arg Gly Phe Gly Arg His Ser His Asp Glu 
    290                 295                 300                 


Ile Ser Ile Leu Ser Pro Leu Ser Gln Cys Cys Met Ile Lys Lys Lys 
305                 310                 315                 320 


Thr Leu Leu His Leu Gln Leu Leu Ala Gln Ala Asp Tyr Arg Leu Ser 
                325                 330                 335     


Asp Val Met Arg Glu Ser Leu Leu Glu Asp Gln Leu Ser Pro Val Leu 
            340                 345                 350         


Thr Glu Pro His Leu Leu Ala Leu Asp Arg Arg Leu Gln Thr Ile Leu 
        355                 360                 365             


Arg Thr Val Glu Gly Cys Ile Val Ala His Gly Gln Gln Ser Val Ile 
    370                 375                 380                 


Val Asp Gly Pro Val Glu Gln Leu Ala Pro Asp Ser Gly Gln Ala Asn 
385                 390                 395                 400 


Leu Thr Ser 
            


<210>  3840
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM20B__Homo_sapiens__NP_055679

<400>  3840

Met Lys Leu Lys Gln Arg Val Val Leu Leu Ala Ile Leu Leu Val Ile 
1               5                   10                  15      


Phe Ile Phe Thr Lys Val Phe Leu Ile Asp Asn Leu Asp Thr Ser Ala 
            20                  25                  30          


Ala Asn Arg Glu Asp Gln Arg Ala Phe His Arg Met Met Thr Gly Leu 
        35                  40                  45              


Arg Val Glu Leu Ala Pro Lys Leu Asp His Thr Leu Gln Ser Pro Trp 
    50                  55                  60                  


Glu Ile Ala Ala Gln Trp Val Val Pro Arg Glu Val Tyr Pro Glu Glu 
65                  70                  75                  80  


Thr Pro Glu Leu Gly Ala Val Met His Ala Met Ala Thr Lys Lys Ile 
                85                  90                  95      


Ile Lys Ala Asp Val Gly Tyr Lys Gly Thr Gln Leu Lys Ala Leu Leu 
            100                 105                 110         


Ile Leu Glu Gly Gly Gln Lys Val Val Phe Lys Pro Lys Arg Tyr Ser 
        115                 120                 125             


Arg Asp His Val Val Glu Gly Glu Pro Tyr Ala Gly Tyr Asp Arg His 
    130                 135                 140                 


Asn Ala Glu Val Ala Ala Phe His Leu Asp Arg Ile Leu Gly Phe His 
145                 150                 155                 160 


Arg Ala Pro Leu Val Val Gly Arg Phe Val Asn Leu Arg Thr Glu Ile 
                165                 170                 175     


Lys Pro Val Ala Thr Glu Gln Leu Leu Ser Thr Phe Leu Thr Val Gly 
            180                 185                 190         


Asn Asn Thr Cys Phe Tyr Gly Lys Cys Tyr Tyr Cys Arg Glu Thr Glu 
        195                 200                 205             


Pro Ala Cys Ala Asp Gly Asp Ile Met Glu Gly Ser Val Thr Leu Trp 
    210                 215                 220                 


Leu Pro Asp Val Trp Pro Leu Gln Lys His Arg His Pro Trp Gly Arg 
225                 230                 235                 240 


Thr Tyr Arg Glu Gly Lys Leu Ala Arg Trp Glu Tyr Asp Glu Ser Tyr 
                245                 250                 255     


Cys Asp Ala Val Lys Lys Thr Ser Pro Tyr Asp Ser Gly Pro Arg Leu 
            260                 265                 270         


Leu Asp Ile Ile Asp Thr Ala Val Phe Asp Tyr Leu Ile Gly Asn Ala 
        275                 280                 285             


Asp Arg His His Tyr Glu Ser Phe Gln Asp Asp Glu Gly Ala Ser Met 
    290                 295                 300                 


Leu Ile Leu Leu Asp Asn Ala Lys Ser Phe Gly Asn Pro Ser Leu Asp 
305                 310                 315                 320 


Glu Arg Ser Ile Leu Ala Pro Leu Tyr Gln Cys Cys Ile Ile Arg Val 
                325                 330                 335     


Ser Thr Trp Asn Arg Leu Asn Tyr Leu Lys Asn Gly Val Leu Lys Ser 
            340                 345                 350         


Ala Leu Lys Ser Ala Met Ala His Asp Pro Ile Ser Pro Val Leu Ser 
        355                 360                 365             


Asp Pro His Leu Asp Ala Val Asp Gln Arg Leu Leu Ser Val Leu Ala 
    370                 375                 380                 


Thr Val Lys Gln Cys Thr Asp Gln Phe Gly Met Asp Thr Val Leu Val 
385                 390                 395                 400 


Glu Asp Arg Met Pro Leu Ser His Leu 
                405                 


<210>  3841
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM20C__Homo_sapiens__NP_064608

<400>  3841

Met Lys Met Met Leu Val Arg Arg Phe Arg Val Leu Ile Leu Met Val 
1               5                   10                  15      


Phe Leu Val Ala Cys Ala Leu His Ile Ala Leu Asp Leu Leu Pro Arg 
            20                  25                  30          


Leu Glu Arg Arg Gly Ala Arg Pro Ser Gly Glu Pro Gly Cys Ser Cys 
        35                  40                  45              


Ala Gln Pro Ala Ala Glu Val Ala Ala Pro Gly Trp Ala Gln Val Arg 
    50                  55                  60                  


Gly Arg Pro Gly Glu Pro Pro Ala Ala Ser Ser Ala Ala Gly Asp Ala 
65                  70                  75                  80  


Gly Trp Pro Asn Lys His Thr Leu Arg Ile Leu Gln Asp Phe Ser Ser 
                85                  90                  95      


Asp Pro Ser Ser Asn Leu Ser Ser His Ser Leu Glu Lys Leu Pro Pro 
            100                 105                 110         


Ala Ala Glu Pro Ala Glu Arg Ala Leu Arg Gly Arg Asp Pro Gly Ala 
        115                 120                 125             


Leu Arg Pro His Asp Pro Ala His Arg Pro Leu Leu Arg Asp Pro Gly 
    130                 135                 140                 


Pro Arg Arg Ser Glu Ser Pro Pro Gly Pro Gly Gly Asp Ala Ser Leu 
145                 150                 155                 160 


Leu Ala Arg Leu Phe Glu His Pro Leu Tyr Arg Val Ala Val Pro Pro 
                165                 170                 175     


Leu Thr Glu Glu Asp Val Leu Phe Asn Val Asn Ser Asp Thr Arg Leu 
            180                 185                 190         


Ser Pro Lys Ala Ala Glu Asn Pro Asp Trp Pro His Ala Gly Ala Glu 
        195                 200                 205             


Gly Ala Glu Phe Leu Ser Pro Gly Glu Ala Ala Val Asp Ser Tyr Pro 
    210                 215                 220                 


Asn Trp Leu Lys Phe His Ile Gly Ile Asn Arg Tyr Glu Leu Tyr Ser 
225                 230                 235                 240 


Arg His Asn Pro Ala Ile Glu Ala Leu Leu His Asp Leu Ser Ser Gln 
                245                 250                 255     


Arg Ile Thr Ser Val Ala Met Lys Ser Gly Gly Thr Gln Leu Lys Leu 
            260                 265                 270         


Ile Met Thr Phe Gln Asn Tyr Gly Gln Ala Leu Phe Lys Pro Met Lys 
        275                 280                 285             


Gln Thr Arg Glu Gln Glu Thr Pro Pro Asp Phe Phe Tyr Phe Ser Asp 
    290                 295                 300                 


Tyr Glu Arg His Asn Ala Glu Ile Ala Ala Phe His Leu Asp Arg Ile 
305                 310                 315                 320 


Leu Asp Phe Arg Arg Val Pro Pro Val Ala Gly Arg Met Val Asn Met 
                325                 330                 335     


Thr Lys Glu Ile Arg Asp Val Thr Arg Asp Lys Lys Leu Trp Arg Thr 
            340                 345                 350         


Phe Phe Ile Ser Pro Ala Asn Asn Ile Cys Phe Tyr Gly Glu Cys Ser 
        355                 360                 365             


Tyr Tyr Cys Ser Thr Glu His Ala Leu Cys Gly Lys Pro Asp Gln Ile 
    370                 375                 380                 


Glu Gly Ser Leu Ala Ala Phe Leu Pro Asp Leu Ser Leu Ala Lys Arg 
385                 390                 395                 400 


Lys Thr Trp Arg Asn Pro Trp Arg Arg Ser Tyr His Lys Arg Lys Lys 
                405                 410                 415     


Ala Glu Trp Glu Val Asp Pro Asp Tyr Cys Glu Glu Val Lys Gln Thr 
            420                 425                 430         


Pro Pro Tyr Asp Ser Ser His Arg Ile Leu Asp Val Met Asp Met Thr 
        435                 440                 445             


Ile Phe Asp Phe Leu Met Gly Asn Met Asp Arg His His Tyr Glu Thr 
    450                 455                 460                 


Phe Glu Lys Phe Gly Asn Glu Thr Phe Ile Ile His Leu Asp Asn Gly 
465                 470                 475                 480 


Arg Gly Phe Gly Lys Tyr Ser His Asp Glu Leu Ser Ile Leu Val Pro 
                485                 490                 495     


Leu Gln Gln Cys Cys Arg Ile Arg Lys Ser Thr Tyr Leu Arg Leu Gln 
            500                 505                 510         


Leu Leu Ala Lys Glu Glu Tyr Lys Leu Ser Leu Leu Met Ala Glu Ser 
        515                 520                 525             


Leu Arg Gly Asp Gln Val Ala Pro Val Leu Tyr Gln Pro His Leu Glu 
    530                 535                 540                 


Ala Leu Asp Arg Arg Leu Arg Val Val Leu Lys Ala Val Arg Asp Cys 
545                 550                 555                 560 


Val Glu Arg Asn Gly Leu His Ser Val Val Asp Asp Asp Leu Asp Thr 
                565                 570                 575     


Glu His Arg Ala Ala Ser Ala Arg 
            580                 


<210>  3842
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM210B__Homo_sapiens__NP_543011

<400>  3842

Met Ala Gly Leu Leu Ala Leu Leu Gly Pro Ala Gly Arg Val Gly Ala 
1               5                   10                  15      


Arg Val Arg Pro Arg Ala Thr Trp Leu Leu Gly Ala Thr Ala Pro Cys 
            20                  25                  30          


Ala Pro Pro Pro Leu Ala Leu Ala Leu Leu Pro Pro Arg Leu Asp Ala 
        35                  40                  45              


Arg Leu Leu Arg Thr Ala Arg Gly Asp Cys Arg Gly His Gln Asp Pro 
    50                  55                  60                  


Ser Gln Ala Thr Gly Thr Thr Gly Ser Ser Val Ser Cys Thr Glu Glu 
65                  70                  75                  80  


Lys Lys Gln Ser Lys Ser Gln Gln Leu Lys Lys Ile Phe Gln Glu Tyr 
                85                  90                  95      


Gly Thr Val Gly Val Ser Leu His Ile Gly Ile Ser Leu Ile Ser Leu 
            100                 105                 110         


Gly Ile Phe Tyr Met Val Val Ser Ser Gly Val Asp Met Pro Ala Ile 
        115                 120                 125             


Leu Leu Lys Leu Gly Phe Lys Glu Ser Leu Val Gln Ser Lys Met Ala 
    130                 135                 140                 


Ala Gly Thr Ser Thr Phe Val Val Ala Tyr Ala Ile His Lys Leu Phe 
145                 150                 155                 160 


Ala Pro Val Arg Ile Ser Ile Thr Leu Val Ser Val Pro Leu Ile Val 
                165                 170                 175     


Arg Tyr Phe Arg Lys Val Gly Phe Phe Lys Pro Pro Ala Ala Lys Pro 
            180                 185                 190         


<210>  3843
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM213A__Homo_sapiens__NP_001230707

<400>  3843

Met Ser Phe Leu Gln Asp Pro Ser Phe Phe Thr Met Gly Met Trp Ser 
1               5                   10                  15      


Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu Leu Ala 
            20                  25                  30          


Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu Glu Tyr 
        35                  40                  45              


Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg Thr Phe 
    50                  55                  60                  


Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met Ala Val 
65                  70                  75                  80  


Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp Leu Ser 
                85                  90                  95      


Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr Ala Val 
            100                 105                 110         


Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro Tyr Phe 
        115                 120                 125             


Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly Pro Gln 
    130                 135                 140                 


Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val Trp Tyr 
145                 150                 155                 160 


Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu Glu Gly 
                165                 170                 175     


Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly Lys Gln 
            180                 185                 190         


Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Lys Val Asn 
        195                 200                 205             


Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln Thr Leu 
    210                 215                 220                 


Ala Ser Glu Lys Lys 
225                 


<210>  3844
<211>  1083
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM214A__Homo_sapiens__NP_001273424

<400>  3844

Met Val Phe Ser Gly Asn Lys Gly Leu His Arg Glu Asp Thr Leu Asp 
1               5                   10                  15      


Glu Tyr Phe Glu Tyr Asp Ala Glu Glu Phe Leu Val Ser Leu Ala Leu 
            20                  25                  30          


Leu Ile Thr Glu Gly Arg Thr Pro Glu Cys Ser Val Lys Gly Arg Thr 
        35                  40                  45              


Glu Ser Phe His Cys Pro Pro Ala Gln Ser Cys Tyr Pro Val Thr Thr 
    50                  55                  60                  


Lys His Glu Cys Ser Asp Lys Leu Ala Gln Cys Arg Gln Ala Arg Arg 
65                  70                  75                  80  


Thr Arg Ser Glu Val Thr Leu Leu Trp Lys Asn Asn Leu Pro Ile Met 
                85                  90                  95      


Val Glu Met Met Leu Leu Pro Asp Cys Cys Tyr Ser Asp Asp Gly Pro 
            100                 105                 110         


Thr Thr Glu Gly Ile Asp Leu Asn Asp Pro Ala Ile Lys Gln Asp Ala 
        115                 120                 125             


Leu Leu Leu Glu Arg Trp Ile Leu Glu Pro Val Pro Arg Gln Asn Gly 
    130                 135                 140                 


Asp Arg Phe Ile Glu Glu Lys Thr Leu Leu Leu Ala Val Arg Ser Phe 
145                 150                 155                 160 


Val Phe Phe Ser Gln Leu Ser Ala Trp Leu Ser Val Ser His Gly Ala 
                165                 170                 175     


Ile Pro Arg Asn Ile Leu Tyr Arg Ile Ser Ala Ala Asp Val Asp Leu 
            180                 185                 190         


Gln Trp Asn Phe Ser Gln Thr Pro Ile Glu His Val Phe Pro Val Pro 
        195                 200                 205             


Asn Val Ser His Asn Val Ala Leu Lys Val Ser Val Gln Ser Leu Pro 
    210                 215                 220                 


Arg Gln Ser Asn Tyr Pro Val Leu Thr Cys Ser Ile His Thr Asn Ile 
225                 230                 235                 240 


Gly Leu Tyr Glu Lys Arg Ile Gln Gln His Lys Leu Lys Thr His Gln 
                245                 250                 255     


His His Asn Pro Asn Glu Ala Glu Gln Cys Gly Thr Asn Ser Ser Gln 
            260                 265                 270         


Arg Leu Cys Ser Lys Gln Thr Trp Thr Met Ala Pro Glu Ser Val Leu 
        275                 280                 285             


His Ala Lys Ser Gly Pro Ser Pro Glu Tyr Thr Ala Ala Val Lys Asn 
    290                 295                 300                 


Ile Lys Leu Tyr Pro Gly Thr Gly Ser Lys Ser Asp His Gly Thr Ser 
305                 310                 315                 320 


Gln Ala Asn Ile Leu Gly Phe Ser Gly Ile Gly Asp Ile Lys Ser Gln 
                325                 330                 335     


Glu Thr Ser Val Arg Thr Leu Lys Ser Phe Ser Met Val Asp Ser Ser 
            340                 345                 350         


Ile Ser Asn Arg Gln Ser Phe Trp Gln Ser Ala Gly Glu Thr Asn Pro 
        355                 360                 365             


Leu Ile Gly Ser Leu Ile Gln Glu Arg Gln Glu Ile Ile Ala Arg Ile 
    370                 375                 380                 


Ala Gln His Leu Ile His Cys Asp Pro Ser Thr Ser His Val Ser Gly 
385                 390                 395                 400 


Arg Pro Phe Asn Thr Gln Glu Ser Ser Ser Leu His Ser Lys Leu Phe 
                405                 410                 415     


Arg Val Ser Gln Glu Asn Glu Asn Val Gly Lys Gly Lys Glu Ala Phe 
            420                 425                 430         


Ser Met Thr Phe Gly Ser Pro Glu Phe Ser Ser Pro Glu Asp Thr Asn 
        435                 440                 445             


Glu Gly Lys Ile Arg Leu Lys Pro Glu Thr Pro Arg Ser Glu Thr Cys 
    450                 455                 460                 


Ile Ser Asn Asp Phe Tyr Ser His Met Pro Val Gly Glu Thr Asn Pro 
465                 470                 475                 480 


Leu Ile Gly Ser Leu Leu Gln Glu Arg Gln Asp Val Ile Ala Arg Ile 
                485                 490                 495     


Ala Gln His Leu Glu His Ile Asp Pro Thr Ala Ser His Ile Pro Arg 
            500                 505                 510         


Gln Ser Phe Asn Met His Asp Ser Ser Ser Val Ala Ser Lys Val Phe 
        515                 520                 525             


Arg Ser Ser Tyr Glu Asp Lys Asn Leu Leu Lys Lys Asn Lys Asp Glu 
    530                 535                 540                 


Ser Ser Val Ser Ile Ser His Thr Lys Cys Ser Leu Leu Gly Asp Ile 
545                 550                 555                 560 


Ser Asp Gly Lys Asn Leu Val Pro Asn Lys Cys Phe Thr Ser Phe Lys 
                565                 570                 575     


Asn Asn Ser Lys Glu Lys Cys Ser Leu Lys His Gln Thr Arg Asn Gln 
            580                 585                 590         


Cys Gln Asn Asn Pro Ser Glu Ile Ile Gln Ser Thr Tyr Gln Glu Thr 
        595                 600                 605             


Gln Asn Lys Ser Ser Ser Leu Ser Thr Ser Ser Ile Leu Ser Gln His 
    610                 615                 620                 


Lys Glu Asn Asn Leu Asp Leu Thr Ser Arg Phe Lys Glu Gln Glu Met 
625                 630                 635                 640 


Ser Asn Gly Ile Asp Lys Gln Tyr Ser Asn Cys Thr Thr Ile Asp Lys 
                645                 650                 655     


Gln Ile Cys Thr Asn Lys Tyr Lys Glu Lys Ile Ile Asn Glu Asn Tyr 
            660                 665                 670         


Asn Pro Lys Phe Phe Gly Asn Leu Gln Ser Asp Asp Ser Lys Lys Asn 
        675                 680                 685             


Asp Ser Lys Ile Lys Val Thr Val Leu Glu Met Ser Glu Tyr Leu Asn 
    690                 695                 700                 


Lys Tyr Glu Ser Met Ser Ser Asn Lys Asp Ser Lys Arg Pro Lys Thr 
705                 710                 715                 720 


Cys Glu Gln Asn Thr Gln Leu Asn Ser Ile Glu Asn Tyr Leu Asn Lys 
                725                 730                 735     


Asp Asn Glu Gly Phe Lys Cys Lys Lys Ser Asp Gln Leu Lys Asn Glu 
            740                 745                 750         


Gln Asp Lys Gln Glu Asp Pro Thr Asn Glu Lys Ser Gln Asn Tyr Ser 
        755                 760                 765             


Gln Arg Arg Ser Ile Lys Asp Cys Leu Ser Thr Cys Glu Gln Pro Lys 
    770                 775                 780                 


Asn Thr Glu Val Leu Arg Thr Thr Leu Lys His Ser Asn Val Trp Arg 
785                 790                 795                 800 


Lys His Asn Phe His Ser Leu Asp Gly Thr Ser Thr Arg Ala Phe His 
                805                 810                 815     


Pro Gln Thr Gly Leu Pro Leu Leu Ser Ser Pro Val Pro Gln Arg Lys 
            820                 825                 830         


Thr Gln Ser Gly Cys Phe Asp Leu Asp Ser Ser Leu Leu His Leu Lys 
        835                 840                 845             


Ser Phe Ser Ser Arg Ser Pro Arg Pro Cys Leu Asn Ile Glu Asp Asp 
    850                 855                 860                 


Pro Asp Ile His Glu Lys Pro Phe Leu Ser Ser Ser Ala Pro Pro Ile 
865                 870                 875                 880 


Thr Ser Leu Ser Leu Leu Gly Asn Phe Glu Glu Ser Val Leu Asn Tyr 
                885                 890                 895     


Arg Phe Asp Pro Leu Gly Ile Val Asp Gly Phe Thr Ala Glu Val Gly 
            900                 905                 910         


Ala Ser Gly Ala Phe Cys Pro Thr His Leu Thr Leu Pro Val Glu Val 
        915                 920                 925             


Ser Phe Tyr Ser Val Ser Asp Asp Asn Ala Pro Ser Pro Tyr Met Gly 
    930                 935                 940                 


Val Ile Thr Leu Glu Ser Leu Gly Lys Arg Gly Tyr Arg Val Pro Pro 
945                 950                 955                 960 


Ser Gly Thr Ile Gln Val Thr Leu Phe Asn Pro Asn Lys Thr Val Val 
                965                 970                 975     


Lys Met Phe Val Val Ile Tyr Asp Leu Arg Asp Met Pro Ala Asn His 
            980                 985                 990         


Gln Thr Phe Leu Arg Gln Arg Thr  Phe Ser Val Pro Val  Lys Gln Glu 
        995                 1000                 1005             


Val Lys  Arg Ser Val Asn Lys  Glu Asn Ile Arg His  Thr Glu Glu 
    1010                 1015                 1020             


Arg Leu  Leu Arg Tyr Leu Ile  His Leu Arg Phe Gln  Ser Ser Lys 
    1025                 1030                 1035             


Ser Gly  Lys Ile Tyr Leu His  Arg Asp Val Arg Leu  Leu Phe Ser 
    1040                 1045                 1050             


Arg Lys  Ser Met Glu Val Asp  Ser Gly Ala Ala Tyr  Glu Leu Lys 
    1055                 1060                 1065             


Ser Tyr  Thr Glu Ser Pro Thr  Asn Pro Gln Phe Ser  Pro Arg Cys 
    1070                 1075                 1080             


<210>  3845
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM216A__Homo_sapiens__NP_037432

<400>  3845

Met Leu Gly Gln Leu Leu Pro His Thr Ala Arg Gly Leu Gly Ala Ala 
1               5                   10                  15      


Glu Met Pro Gly Gln Gly Pro Gly Ser Asp Trp Thr Glu Arg Ser Ser 
            20                  25                  30          


Ser Ala Glu Pro Pro Ala Val Ala Gly Thr Glu Gly Gly Gly Gly Gly 
        35                  40                  45              


Ser Ala Gly Tyr Ser Cys Tyr Gln Asn Ser Lys Gly Ser Asp Arg Ile 
    50                  55                  60                  


Lys Asp Gly Tyr Lys Val Asn Ser His Ile Ala Lys Leu Gln Glu Leu 
65                  70                  75                  80  


Trp Lys Thr Pro Gln Asn Gln Thr Ile His Leu Ser Lys Ser Met Met 
                85                  90                  95      


Glu Ala Ser Phe Phe Lys His Pro Asp Leu Thr Thr Gly Gln Lys Arg 
            100                 105                 110         


Tyr Leu Cys Ser Ile Ala Lys Ile Tyr Asn Ala Asn Tyr Leu Lys Met 
        115                 120                 125             


Leu Met Lys Arg Gln Tyr Met His Val Leu Gln His Ser Ser Gln Lys 
    130                 135                 140                 


Pro Gly Val Leu Thr His His Arg Ser Arg Leu Ser Ser Arg Tyr Ser 
145                 150                 155                 160 


Gln Lys Gln His Tyr Pro Cys Thr Thr Trp Arg His Gln Leu Glu Arg 
                165                 170                 175     


Glu Asp Ser Gly Ser Ser Asp Ile Ala Ala Ala Ser Ala Pro Glu Met 
            180                 185                 190         


Leu Ile Gln His Ser Leu Trp Arg Pro Val Arg Asn Lys Glu Gly Ile 
        195                 200                 205             


Lys Thr Gly Tyr Ala Ser Lys Thr Arg Cys Lys Ser Leu Lys Ile Phe 
    210                 215                 220                 


Arg Arg Pro Arg Lys Leu Phe Met Gln Thr Val Ser Ser Asp Asp Ser 
225                 230                 235                 240 


Glu Ser His Met Ser Glu Glu Lys Lys Glu Glu Asp Leu Leu Asn Asn 
                245                 250                 255     


Phe Met Gln Ser Met Ser Ile Glu Glu Gln Gly Glu His Leu Met Leu 
            260                 265                 270         


Thr 
    


<210>  3846
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM220A__Homo_sapiens__NP_001032240

<400>  3846

Met Arg Asp Arg Arg Gly Pro Leu Gly Thr Cys Leu Ala Gln Val Gln 
1               5                   10                  15      


Gln Ala Gly Gly Gly Asp Ser Asp Lys Leu Ser Cys Ser Leu Lys Lys 
            20                  25                  30          


Arg Met Pro Glu Gly Pro Trp Pro Ala Asp Ala Pro Ser Trp Met Asn 
        35                  40                  45              


Lys Pro Val Val Asp Gly Asn Ser Gln Ser Glu Ala Leu Ser Leu Glu 
    50                  55                  60                  


Met Arg Lys Asp Pro Ser Gly Ala Gly Leu Trp Leu His Ser Gly Gly 
65                  70                  75                  80  


Pro Val Leu Pro Tyr Val Arg Glu Ser Val Arg Arg Asn Pro Ala Ser 
                85                  90                  95      


Ala Ala Thr Pro Ser Thr Ala Val Gly Leu Phe Pro Ala Pro Thr Glu 
            100                 105                 110         


Cys Phe Ala Arg Val Ser Cys Ser Gly Val Glu Ala Leu Gly Arg Arg 
        115                 120                 125             


Asp Trp Leu Gly Gly Gly Pro Arg Ala Thr Asp Gly His Arg Gly Gln 
    130                 135                 140                 


Cys Pro Lys Gly Glu Pro Arg Val Ser Arg Leu Pro Arg His Gln Lys 
145                 150                 155                 160 


Val Pro Glu Met Gly Ser Phe Gln Asp Asp Pro Pro Ser Ala Phe Pro 
                165                 170                 175     


Lys Gly Leu Gly Ser Glu Leu Glu Pro Ala Cys Leu His Ser Ile Leu 
            180                 185                 190         


Ser Ala Thr Leu His Val Tyr Pro Glu Val Leu Leu Ser Glu Glu Thr 
        195                 200                 205             


Lys Arg Ile Phe Leu Asp Arg Leu Lys Pro Met Phe Ser Lys Gln Thr 
    210                 215                 220                 


Ile Glu Phe Lys Lys Met Leu Lys Ser Thr Ser Asp Gly Leu Gln Ile 
225                 230                 235                 240 


Thr Leu Gly Leu Leu Ala Leu Gln Pro Phe Glu Leu Ala Asn Thr Leu 
                245                 250                 255     


Cys His Ser 
            


<210>  3847
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM227B__Homo_sapiens__NP_689860

<400>  3847

Met Ala Gly Gln Arg Thr Cys Gln Arg Arg Ser Ser Arg Ala Gly Pro 
1               5                   10                  15      


Gly Lys Met Gln Glu Pro Pro Lys Ser Ile Glu Glu Phe Leu Lys Phe 
            20                  25                  30          


Gln Asn Trp Asp Tyr Trp Pro Arg Glu Ile His Phe Arg Asp Asp Asp 
        35                  40                  45              


Lys Trp Ser Cys Thr Leu Lys Lys Ile Lys Glu Asp Ser Ser Phe Val 
    50                  55                  60                  


Ser Ile Tyr Thr His Leu Trp Glu Asn Val Pro Arg Ile Phe Glu Ala 
65                  70                  75                  80  


Leu Leu Ile Met Glu Ser Lys Leu Lys Glu Tyr Ser Leu Ile Leu Gln 
                85                  90                  95      


Asn His Thr Ser Glu Ile Phe Lys Trp Lys Ser Met Ile Ser Glu Thr 
            100                 105                 110         


Ser Ser Tyr Arg Lys Leu Glu Arg Tyr Gly Glu Phe Leu Lys Lys Tyr 
        115                 120                 125             


His Lys Lys Lys Lys Ile Met Leu Ser Asp Glu Met Glu Thr Glu Lys 
    130                 135                 140                 


Asn Ile Glu Gly Cys Ser Phe Thr Gly Phe Lys Ala Asn Glu Leu Thr 
145                 150                 155                 160 


Gln Leu Pro Arg His Leu Asp Ala Glu Gln Ile Tyr Leu Phe Ile Leu 
                165                 170                 175     


Lys Ala His Asn Phe Asp Glu Arg Val Phe Lys Ile Trp Lys Thr His 
            180                 185                 190         


Phe Leu Ser Glu Ala Ser Ile Ala Leu Leu His Asp Ser Phe Trp Trp 
        195                 200                 205             


Trp Phe Leu His Lys Phe Arg Pro Asp Arg Glu Asn Gln Asp Cys Leu 
    210                 215                 220                 


Phe Asp Arg Ile Ser Glu Ser Tyr Val Thr Leu Phe Met Ser Ile Pro 
225                 230                 235                 240 


Leu Ser Arg Lys Asp Ala Phe Phe Gln Ile Tyr Pro Asp Cys Leu Ala 
                245                 250                 255     


Gln Ala Ile Tyr Ala Thr Phe His Glu Ala Phe Pro Glu Ser Ser Tyr 
            260                 265                 270         


Leu Phe Asn Asp Glu Phe Lys Glu Asp Leu Gly Asn Asn Ile Phe Leu 
        275                 280                 285             


Trp Cys Ser Gly Leu Lys Pro Gln Lys Gly Phe Trp Ile His Trp Lys 
    290                 295                 300                 


Leu Lys Glu Leu Ser Thr Thr Thr Ile His Gly Ser Lys Lys Ala Pro 
305                 310                 315                 320 


Ala Lys Ser Val Lys Glu Arg Ile Ala Asp Ser Gln Glu His Ile Ser 
                325                 330                 335     


Thr Ser Ile Asp Phe Asn Ile Ile Lys Ile Leu Asn Asn Pro Arg Ala 
            340                 345                 350         


Tyr Thr Leu Pro Ile Ser Lys Glu Glu Ser Arg Leu Ser Arg Leu Ala 
        355                 360                 365             


Thr Lys Ser His Tyr Ser Ser Thr Gly Pro Glu Phe Asn Arg Val Leu 
    370                 375                 380                 


Phe Asn Phe Gly Gly Gln Ser Pro Leu Ile Leu Tyr Tyr Leu Lys Met 
385                 390                 395                 400 


His Glu Leu Ala Gly Ile Ser Lys Ala Pro Lys Lys Thr Lys Ile Lys 
                405                 410                 415     


Leu Thr Lys Ile Phe Gln Glu Pro Leu Pro Ala Pro Thr Tyr Arg Asp 
            420                 425                 430         


Val Ile Lys Glu Ala Lys Arg Gln Phe Ala Arg Asn Gln Lys Asp Phe 
        435                 440                 445             


Arg Ile Leu Gln Ala Lys Ala Thr Lys Lys Pro His Glu Val Lys Gln 
    450                 455                 460                 


Asp Phe Glu Lys Phe Leu His Lys Leu Arg Ser Glu Ala Glu Ile Glu 
465                 470                 475                 480 


Arg Glu Cys Val Ala Ser Leu Ser Ser Ser Ser Ser Ser Ser Pro Ser 
                485                 490                 495     


Ser Thr Asp Asn Tyr Asn Phe Glu Glu Glu Glu Tyr 
            500                 505             


<210>  3848
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM32A__Homo_sapiens__NP_054796

<400>  3848

Met Glu Ala Tyr Glu Gln Val Gln Lys Gly Pro Leu Lys Leu Lys Gly 
1               5                   10                  15      


Val Ala Glu Leu Gly Val Thr Lys Arg Lys Lys Lys Lys Lys Asp Lys 
            20                  25                  30          


Asp Lys Ala Lys Leu Leu Glu Ala Met Gly Thr Ser Lys Lys Asn Glu 
        35                  40                  45              


Glu Glu Lys Arg Arg Gly Leu Asp Lys Arg Thr Pro Ala Gln Ala Ala 
    50                  55                  60                  


Phe Glu Lys Met Gln Glu Lys Arg Gln Met Glu Arg Ile Leu Lys Lys 
65                  70                  75                  80  


Ala Ser Lys Thr His Lys Gln Arg Val Glu Asp Phe Asn Arg His Leu 
                85                  90                  95      


Asp Thr Leu Thr Glu His Tyr Asp Ile Pro Lys Val Ser Trp Thr Lys 
            100                 105                 110         


<210>  3849
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM3A__Homo_sapiens__NP_001164604

<400>  3849

Met Arg Leu Ala Gly Pro Glu Ser Ser Val Thr Ala Ala Pro Arg Ala 
1               5                   10                  15      


Arg Lys Tyr Lys Cys Gly Leu Pro Gln Pro Cys Pro Glu Glu His Leu 
            20                  25                  30          


Ala Phe Arg Val Val Ser Gly Ala Ala Asn Val Ile Gly Pro Lys Ile 
        35                  40                  45              


Cys Leu Glu Asp Lys Met Leu Met Ser Ser Val Lys Asp Asn Val Gly 
    50                  55                  60                  


Arg Gly Leu Asn Ile Ala Leu Val Asn Gly Val Ser Gly Glu Leu Ile 
65                  70                  75                  80  


Glu Ala Arg Ala Phe Asp Met Trp Ala Gly Asp Val Asn Asp Leu Leu 
                85                  90                  95      


Lys Phe Ile Arg Pro Leu His Glu Gly Thr Leu Val Phe Val Ala Ser 
            100                 105                 110         


Tyr Asp Asp Pro Ala Thr Lys Met Asn Glu Glu Thr Arg Lys Leu Phe 
        115                 120                 125             


Ser Glu Leu Gly Ser Arg Asn Ala Lys Glu Leu Ala Phe Arg Asp Ser 
    130                 135                 140                 


Trp Val Phe Val Gly Ala Lys Gly Val Gln Asn Lys Ser Pro Phe Glu 
145                 150                 155                 160 


Gln His Val Lys Asn Ser Lys His Ser Asn Lys Tyr Glu Gly Trp Pro 
                165                 170                 175     


Glu Ala Leu Glu Met Glu Gly Cys Ile Pro Arg Arg Ser Thr Ala Ser 
            180                 185                 190         


<210>  3850
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM3B__Homo_sapiens__NP_478066

<400>  3850

Met Arg Pro Leu Ala Gly Gly Leu Leu Lys Val Val Phe Val Val Phe 
1               5                   10                  15      


Ala Ser Leu Cys Ala Trp Tyr Ser Gly Tyr Leu Leu Ala Glu Leu Ile 
            20                  25                  30          


Pro Asp Ala Pro Leu Ser Ser Ala Ala Tyr Ser Ile Arg Ser Ile Gly 
        35                  40                  45              


Glu Arg Pro Val Leu Lys Ala Pro Val Pro Lys Arg Gln Lys Cys Asp 
    50                  55                  60                  


His Trp Thr Pro Cys Pro Ser Asp Thr Tyr Ala Tyr Arg Leu Leu Ser 
65                  70                  75                  80  


Gly Gly Gly Arg Ser Lys Tyr Ala Lys Ile Cys Phe Glu Asp Asn Leu 
                85                  90                  95      


Leu Met Gly Glu Gln Leu Gly Asn Val Ala Arg Gly Ile Asn Ile Ala 
            100                 105                 110         


Ile Val Asn Tyr Val Thr Gly Asn Val Thr Ala Thr Arg Cys Phe Asp 
        115                 120                 125             


Met Tyr Glu Gly Asp Asn Ser Gly Pro Met Thr Lys Phe Ile Gln Ser 
    130                 135                 140                 


Ala Ala Pro Lys Ser Leu Leu Phe Met Val Thr Tyr Asp Asp Gly Ser 
145                 150                 155                 160 


Thr Arg Leu Asn Asn Asp Ala Lys Asn Ala Ile Glu Ala Leu Gly Ser 
                165                 170                 175     


Lys Glu Ile Arg Asn Met Lys Phe Arg Ser Ser Trp Val Phe Ile Ala 
            180                 185                 190         


Ala Lys Gly Leu Glu Leu Pro Ser Glu Ile Gln Arg Glu Lys Ile Asn 
        195                 200                 205             


His Ser Asp Ala Lys Asn Asn Arg Tyr Ser Gly Trp Pro Ala Glu Ile 
    210                 215                 220                 


Gln Ile Glu Gly Cys Ile Pro Lys Glu Arg Ser 
225                 230                 235 


<210>  3851
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM3C__Homo_sapiens__NP_055703

<400>  3851

Met Arg Val Ala Gly Ala Ala Lys Leu Val Val Ala Val Ala Val Phe 
1               5                   10                  15      


Leu Leu Thr Phe Tyr Val Ile Ser Gln Val Phe Glu Ile Lys Met Asp 
            20                  25                  30          


Ala Ser Leu Gly Asn Leu Phe Ala Arg Ser Ala Leu Asp Thr Ala Ala 
        35                  40                  45              


Arg Ser Thr Lys Pro Pro Arg Tyr Lys Cys Gly Ile Ser Lys Ala Cys 
    50                  55                  60                  


Pro Glu Lys His Phe Ala Phe Lys Met Ala Ser Gly Ala Ala Asn Val 
65                  70                  75                  80  


Val Gly Pro Lys Ile Cys Leu Glu Asp Asn Val Leu Met Ser Gly Val 
                85                  90                  95      


Lys Asn Asn Val Gly Arg Gly Ile Asn Val Ala Leu Ala Asn Gly Lys 
            100                 105                 110         


Thr Gly Glu Val Leu Asp Thr Lys Tyr Phe Asp Met Trp Gly Gly Asp 
        115                 120                 125             


Val Ala Pro Phe Ile Glu Phe Leu Lys Ala Ile Gln Asp Gly Thr Ile 
    130                 135                 140                 


Val Leu Met Gly Thr Tyr Asp Asp Gly Ala Thr Lys Leu Asn Asp Glu 
145                 150                 155                 160 


Ala Arg Arg Leu Ile Ala Asp Leu Gly Ser Thr Ser Ile Thr Asn Leu 
                165                 170                 175     


Gly Phe Arg Asp Asn Trp Val Phe Cys Gly Gly Lys Gly Ile Lys Thr 
            180                 185                 190         


Lys Ser Pro Phe Glu Gln His Ile Lys Asn Asn Lys Asp Thr Asn Lys 
        195                 200                 205             


Tyr Glu Gly Trp Pro Glu Val Val Glu Met Glu Gly Cys Ile Pro Gln 
    210                 215                 220                 


Lys Gln Asp 
225         


<210>  3852
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM3D__Homo_sapiens__NP_620160

<400>  3852

Met Arg Val Ser Gly Val Leu Arg Leu Leu Ala Leu Ile Phe Ala Ile 
1               5                   10                  15      


Val Thr Thr Trp Met Phe Ile Arg Ser Tyr Met Ser Phe Ser Met Lys 
            20                  25                  30          


Thr Ile Arg Leu Pro Arg Trp Leu Ala Ala Ser Pro Thr Lys Glu Ile 
        35                  40                  45              


Gln Val Lys Lys Tyr Lys Cys Gly Leu Ile Lys Pro Cys Pro Ala Asn 
    50                  55                  60                  


Tyr Phe Ala Phe Lys Ile Cys Ser Gly Ala Ala Asn Val Val Gly Pro 
65                  70                  75                  80  


Thr Met Cys Phe Glu Asp Arg Met Ile Met Ser Pro Val Lys Asn Asn 
                85                  90                  95      


Val Gly Arg Gly Leu Asn Ile Ala Leu Val Asn Gly Thr Thr Gly Ala 
            100                 105                 110         


Val Leu Gly Gln Lys Ala Phe Asp Met Tyr Ser Gly Asp Val Met His 
        115                 120                 125             


Leu Val Lys Phe Leu Lys Glu Ile Pro Gly Gly Ala Leu Val Leu Val 
    130                 135                 140                 


Ala Ser Tyr Asp Asp Pro Gly Thr Lys Met Asn Asp Glu Ser Arg Lys 
145                 150                 155                 160 


Leu Phe Ser Asp Leu Gly Ser Ser Tyr Ala Lys Gln Leu Gly Phe Arg 
                165                 170                 175     


Asp Ser Trp Val Phe Ile Gly Ala Lys Asp Leu Arg Gly Lys Ser Pro 
            180                 185                 190         


Phe Glu Gln Phe Leu Lys Asn Ser Pro Asp Thr Asn Lys Tyr Glu Gly 
        195                 200                 205             


Trp Pro Glu Leu Leu Glu Met Glu Gly Cys Met Pro Pro Lys Pro Phe 
    210                 215                 220                 


<210>  3853
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM46A__Homo_sapiens__NP_060103

<400>  3853

Met Ala Glu Gly Glu Gly Tyr Phe Ala Met Ser Glu Asp Glu Leu Ala 
1               5                   10                  15      


Cys Ser Pro Tyr Ile Pro Leu Gly Gly Asp Phe Gly Gly Gly Asp Phe 
            20                  25                  30          


Gly Gly Gly Asp Phe Gly Gly Gly Asp Phe Gly Gly Gly Gly Ser Phe 
        35                  40                  45              


Gly Gly His Cys Leu Asp Tyr Cys Glu Ser Pro Thr Ala His Cys Asn 
    50                  55                  60                  


Val Leu Asn Trp Glu Gln Val Gln Arg Leu Asp Gly Ile Leu Ser Glu 
65                  70                  75                  80  


Thr Ile Pro Ile His Gly Arg Gly Asn Phe Pro Thr Leu Glu Leu Gln 
                85                  90                  95      


Pro Ser Leu Ile Val Lys Val Val Arg Arg Arg Leu Ala Glu Lys Arg 
            100                 105                 110         


Ile Gly Val Arg Asp Val Arg Leu Asn Gly Ser Ala Ala Ser His Val 
        115                 120                 125             


Leu His Gln Asp Ser Gly Leu Gly Tyr Lys Asp Leu Asp Leu Ile Phe 
    130                 135                 140                 


Cys Ala Asp Leu Arg Gly Glu Gly Glu Phe Gln Thr Val Lys Asp Val 
145                 150                 155                 160 


Val Leu Asp Cys Leu Leu Asp Phe Leu Pro Glu Gly Val Asn Lys Glu 
                165                 170                 175     


Lys Ile Thr Pro Leu Thr Leu Lys Glu Ala Tyr Val Gln Lys Met Val 
            180                 185                 190         


Lys Val Cys Asn Asp Ser Asp Arg Trp Ser Leu Ile Ser Leu Ser Asn 
        195                 200                 205             


Asn Ser Gly Lys Asn Val Glu Leu Lys Phe Val Asp Ser Leu Arg Arg 
    210                 215                 220                 


Gln Phe Glu Phe Ser Val Asp Ser Phe Gln Ile Lys Leu Asp Ser Leu 
225                 230                 235                 240 


Leu Leu Phe Tyr Glu Cys Ser Glu Asn Pro Met Thr Glu Thr Phe His 
                245                 250                 255     


Pro Thr Ile Ile Gly Glu Ser Val Tyr Gly Asp Phe Gln Glu Ala Phe 
            260                 265                 270         


Asp His Leu Cys Asn Lys Ile Ile Ala Thr Arg Asn Pro Glu Glu Ile 
        275                 280                 285             


Arg Gly Gly Gly Leu Leu Lys Tyr Cys Asn Leu Leu Val Arg Gly Phe 
    290                 295                 300                 


Arg Pro Ala Ser Asp Glu Ile Lys Thr Leu Gln Arg Tyr Met Cys Ser 
305                 310                 315                 320 


Arg Phe Phe Ile Asp Phe Ser Asp Ile Gly Glu Gln Gln Arg Lys Leu 
                325                 330                 335     


Glu Ser Tyr Leu Gln Asn His Phe Val Gly Leu Glu Asp Arg Lys Tyr 
            340                 345                 350         


Glu Tyr Leu Met Thr Leu His Gly Val Val Asn Glu Ser Thr Val Cys 
        355                 360                 365             


Leu Met Gly His Glu Arg Arg Gln Thr Leu Asn Leu Ile Thr Met Leu 
    370                 375                 380                 


Ala Ile Arg Val Leu Ala Asp Gln Asn Val Ile Pro Asn Val Ala Asn 
385                 390                 395                 400 


Val Thr Cys Tyr Tyr Gln Pro Ala Pro Tyr Val Ala Asp Ala Asn Phe 
                405                 410                 415     


Ser Asn Tyr Tyr Ile Ala Gln Val Gln Pro Val Phe Thr Cys Gln Gln 
            420                 425                 430         


Gln Thr Tyr Ser Thr Trp Leu Pro Cys Asn 
        435                 440         


<210>  3854
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM46D__Homo_sapiens__NP_689843

<400>  3854

Met Ser Glu Ile Arg Phe Thr Asn Leu Thr Trp Asp Gln Val Ile Thr 
1               5                   10                  15      


Leu Asp Gln Val Leu Asp Glu Val Ile Pro Ile His Gly Lys Gly Asn 
            20                  25                  30          


Phe Pro Thr Met Glu Val Lys Pro Lys Asp Ile Ile His Val Val Lys 
        35                  40                  45              


Asp Gln Leu Ile Gly Gln Gly Ile Ile Val Lys Asp Ala Arg Leu Asn 
    50                  55                  60                  


Gly Ser Val Ala Ser Tyr Ile Leu Ala Ser His Asn Gly Ile Ser Tyr 
65                  70                  75                  80  


Lys Asp Leu Asp Val Ile Phe Gly Val Glu Leu Pro Gly Asn Glu Glu 
                85                  90                  95      


Phe Gln Val Val Lys Asp Ala Val Leu Asp Cys Leu Leu Asp Phe Leu 
            100                 105                 110         


Pro Lys Asp Val Lys Lys Glu Lys Leu Ser Pro Asp Ile Met Lys Asp 
        115                 120                 125             


Ala Tyr Val Gln Lys Leu Val Lys Val Cys Asn Gly His Asp Cys Trp 
    130                 135                 140                 


Ser Leu Ile Ser Leu Ser Asn Asn Thr Gly Lys Asn Leu Glu Leu Lys 
145                 150                 155                 160 


Phe Val Ser Ser Leu Arg Arg Gln Phe Glu Phe Ser Val Asp Ser Phe 
                165                 170                 175     


Gln Ile Val Leu Asp Pro Met Leu Asp Phe Tyr Ser Asp Lys Asn Ala 
            180                 185                 190         


Lys Leu Thr Lys Glu Ser Tyr Pro Val Val Val Ala Glu Ser Met Tyr 
        195                 200                 205             


Gly Asp Phe Gln Glu Ala Met Thr His Leu Gln His Lys Leu Ile Cys 
    210                 215                 220                 


Thr Arg Lys Pro Glu Glu Ile Arg Gly Gly Gly Leu Leu Lys Tyr Cys 
225                 230                 235                 240 


Ser Leu Leu Val His Gly Phe Lys Pro Ala Cys Met Ser Glu Ile Lys 
                245                 250                 255     


Asn Leu Glu Arg Tyr Met Cys Ser Arg Phe Phe Ile Asp Phe Pro His 
            260                 265                 270         


Ile Glu Glu Gln Gln Lys Lys Ile Glu Ser Tyr Leu His Asn His Phe 
        275                 280                 285             


Ile Gly Glu Gly Met Thr Lys Tyr Asp Tyr Leu Met Thr Leu His Gly 
    290                 295                 300                 


Val Val Asn Glu Ser Thr Val Cys Leu Met Ser Tyr Glu Arg Arg Gln 
305                 310                 315                 320 


Ile Leu His Leu Ile Thr Met Met Ala Leu Lys Val Leu Gly Glu Leu 
                325                 330                 335     


Asn Ile Leu Pro Asn Thr Gln Lys Val Thr Cys Phe Tyr Gln Pro Ala 
            340                 345                 350         


Pro Tyr Phe Ala Ala Glu Ala Arg Tyr Pro Ile Tyr Val Ile Pro Glu 
        355                 360                 365             


Pro Pro Pro Val Ser Phe Gln Pro Tyr His Pro Leu His Phe Arg Gly 
    370                 375                 380                 


Ser Asn Gly Met Ser 
385                 


<210>  3855
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM49A__Homo_sapiens__NP_110424

<400>  3855

Met Gly Asn Leu Leu Lys Val Leu Thr Arg Glu Ile Glu Asn Tyr Pro 
1               5                   10                  15      


His Phe Phe Leu Asp Phe Glu Asn Ala Gln Pro Thr Glu Gly Glu Arg 
            20                  25                  30          


Glu Ile Trp Asn Gln Ile Ser Ala Val Leu Gln Asp Ser Glu Ser Ile 
        35                  40                  45              


Leu Ala Asp Leu Gln Ala Tyr Lys Gly Ala Gly Pro Glu Ile Arg Asp 
    50                  55                  60                  


Ala Ile Gln Asn Pro Asn Asp Ile Gln Leu Gln Glu Lys Ala Trp Asn 
65                  70                  75                  80  


Ala Val Cys Pro Leu Val Val Arg Leu Lys Arg Phe Tyr Glu Phe Ser 
                85                  90                  95      


Ile Arg Leu Glu Lys Ala Leu Gln Ser Leu Leu Glu Ser Leu Thr Cys 
            100                 105                 110         


Pro Pro Tyr Thr Pro Thr Gln His Leu Glu Arg Glu Gln Ala Leu Ala 
        115                 120                 125             


Lys Glu Phe Ala Glu Ile Leu His Phe Thr Leu Arg Phe Asp Glu Leu 
    130                 135                 140                 


Lys Met Arg Asn Pro Ala Ile Gln Asn Asp Phe Ser Tyr Tyr Arg Arg 
145                 150                 155                 160 


Thr Ile Ser Arg Asn Arg Ile Asn Asn Met His Leu Asp Ile Glu Asn 
                165                 170                 175     


Glu Val Asn Asn Glu Met Ala Asn Arg Met Ser Leu Phe Tyr Ala Glu 
            180                 185                 190         


Ala Thr Pro Met Leu Lys Thr Leu Ser Asn Ala Thr Met His Phe Val 
        195                 200                 205             


Ser Glu Asn Lys Thr Leu Pro Ile Glu Asn Thr Thr Asp Cys Leu Ser 
    210                 215                 220                 


Thr Met Thr Ser Val Cys Lys Val Met Leu Glu Thr Pro Glu Tyr Arg 
225                 230                 235                 240 


Ser Arg Phe Thr Ser Glu Glu Thr Leu Met Phe Cys Met Arg Val Met 
                245                 250                 255     


Val Gly Val Ile Ile Leu Tyr Asp His Val His Pro Val Gly Ala Phe 
            260                 265                 270         


Cys Lys Thr Ser Lys Ile Asp Met Lys Gly Cys Ile Lys Val Leu Lys 
        275                 280                 285             


Glu Gln Ala Pro Asp Ser Val Glu Gly Leu Leu Asn Ala Leu Arg Phe 
    290                 295                 300                 


Thr Thr Lys His Leu Asn Asp Glu Ser Thr Ser Lys Gln Ile Arg Ala 
305                 310                 315                 320 


Met Leu Gln 
            


<210>  3856
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM49B__Homo_sapiens__NP_001243692

<400>  3856

Met Gly Asn Leu Leu Lys Val Leu Thr Cys Thr Asp Leu Glu Gln Gly 
1               5                   10                  15      


Pro Asn Phe Phe Leu Asp Phe Glu Asn Ala Gln Pro Thr Glu Ser Glu 
            20                  25                  30          


Lys Glu Ile Tyr Asn Gln Val Asn Val Val Leu Lys Asp Ala Glu Gly 
        35                  40                  45              


Ile Leu Glu Asp Leu Gln Ser Tyr Arg Gly Ala Gly His Glu Ile Arg 
    50                  55                  60                  


Glu Ala Ile Gln His Pro Ala Asp Glu Lys Leu Gln Glu Lys Ala Trp 
65                  70                  75                  80  


Gly Ala Val Val Pro Leu Val Gly Lys Leu Lys Lys Phe Tyr Glu Phe 
                85                  90                  95      


Ser Gln Arg Leu Glu Ala Ala Leu Arg Gly Leu Leu Gly Ala Leu Thr 
            100                 105                 110         


Ser Thr Pro Tyr Ser Pro Thr Gln His Leu Glu Arg Glu Gln Ala Leu 
        115                 120                 125             


Ala Lys Gln Phe Ala Glu Ile Leu His Phe Thr Leu Arg Phe Asp Glu 
    130                 135                 140                 


Leu Lys Met Thr Asn Pro Ala Ile Gln Asn Asp Phe Ser Tyr Tyr Arg 
145                 150                 155                 160 


Arg Thr Leu Ser Arg Met Arg Ile Asn Asn Val Pro Ala Glu Gly Glu 
                165                 170                 175     


Asn Glu Val Asn Asn Glu Leu Ala Asn Arg Met Ser Leu Phe Tyr Ala 
            180                 185                 190         


Glu Ala Thr Pro Met Leu Lys Thr Leu Ser Asp Ala Thr Thr Lys Phe 
        195                 200                 205             


Val Ser Glu Asn Lys Asn Leu Pro Ile Glu Asn Thr Thr Asp Cys Leu 
    210                 215                 220                 


Ser Thr Met Ala Ser Val Cys Arg Val Met Leu Glu Thr Pro Glu Tyr 
225                 230                 235                 240 


Arg Ser Arg Phe Thr Asn Glu Glu Thr Val Ser Phe Cys Leu Arg Val 
                245                 250                 255     


Met Val Gly Val Ile Ile Leu Tyr Asp His Val His Pro Val Gly Ala 
            260                 265                 270         


Phe Ala Lys Thr Ser Lys Ile Asp Met Lys Gly Cys Ile Lys Val Leu 
        275                 280                 285             


Lys Asp Gln Pro Pro Asn Ser Val Glu Gly Leu Leu Asn Ala Leu Arg 
    290                 295                 300                 


Tyr Thr Thr Lys His Leu Asn Asp Glu Thr Thr Ser Lys Gln Ile Lys 
305                 310                 315                 320 


Ser Met Leu Gln 
                


<210>  3857
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM50B__Homo_sapiens__NP_036267

<400>  3857

Met Ala Gln Tyr Lys Gly Thr Met Arg Glu Ala Gly Arg Ala Met His 
1               5                   10                  15      


Leu Leu Lys Lys Arg Glu Arg Gln Arg Glu Gln Met Glu Val Leu Lys 
            20                  25                  30          


Gln Arg Ile Ala Glu Glu Thr Ile Leu Lys Ser Gln Val Asp Lys Arg 
        35                  40                  45              


Phe Ser Ala His Tyr Asp Ala Val Glu Ala Glu Leu Lys Ser Ser Thr 
    50                  55                  60                  


Val Gly Leu Val Thr Leu Asn Asp Met Lys Ala Arg Gln Glu Ala Leu 
65                  70                  75                  80  


Val Arg Glu Arg Glu Arg Gln Leu Ala Lys Arg Gln His Leu Glu Glu 
                85                  90                  95      


Gln Arg Leu Gln Gln Glu Arg Gln Arg Glu Gln Glu Gln Arg Arg Glu 
            100                 105                 110         


Arg Lys Arg Lys Ile Ser Cys Leu Ser Phe Ala Leu Asp Asp Leu Asp 
        115                 120                 125             


Asp Gln Ala Asp Ala Ala Glu Ala Arg Arg Ala Gly Asn Leu Gly Lys 
    130                 135                 140                 


Asn Pro Asp Val Asp Thr Ser Phe Leu Pro Asp Arg Asp Arg Glu Glu 
145                 150                 155                 160 


Glu Glu Asn Arg Leu Arg Glu Glu Leu Arg Gln Glu Trp Glu Ala Gln 
                165                 170                 175     


Arg Glu Lys Val Lys Asp Glu Glu Met Glu Val Thr Phe Ser Tyr Trp 
            180                 185                 190         


Asp Gly Ser Gly His Arg Arg Thr Val Arg Val Arg Lys Gly Asn Thr 
        195                 200                 205             


Val Gln Gln Phe Leu Lys Lys Ala Leu Gln Gly Leu Arg Lys Asp Phe 
    210                 215                 220                 


Leu Glu Leu Arg Ser Ala Gly Val Glu Gln Leu Met Phe Ile Lys Glu 
225                 230                 235                 240 


Asp Leu Ile Leu Pro His Tyr His Thr Phe Tyr Asp Phe Ile Ile Ala 
                245                 250                 255     


Arg Ala Arg Gly Lys Ser Gly Pro Leu Phe Ser Phe Asp Val His Asp 
            260                 265                 270         


Asp Val Arg Leu Leu Ser Asp Ala Thr Met Glu Lys Asp Glu Ser His 
        275                 280                 285             


Ala Gly Lys Val Val Leu Arg Ser Trp Tyr Glu Lys Asn Lys His Ile 
    290                 295                 300                 


Phe Pro Ala Ser Arg Trp Glu Ala Tyr Asp Pro Glu Lys Lys Trp Asp 
305                 310                 315                 320 


Lys Tyr Thr Ile Arg 
                325 


<210>  3858
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM53B__Homo_sapiens__NP_055476

<400>  3858

Met Val Met Val Leu Ser Glu Ser Leu Ser Thr Arg Gly Ala Asp Ser 
1               5                   10                  15      


Ile Ala Cys Gly Thr Phe Ser Arg Glu Leu His Thr Pro Lys Lys Met 
            20                  25                  30          


Ser Gln Gly Pro Thr Leu Phe Ser Cys Gly Ile Met Glu Asn Asp Arg 
        35                  40                  45              


Trp Arg Asp Leu Asp Arg Lys Cys Pro Leu Gln Ile Asp Gln Pro Ser 
    50                  55                  60                  


Thr Ser Ile Trp Glu Cys Leu Pro Glu Lys Asp Ser Ser Leu Trp His 
65                  70                  75                  80  


Arg Glu Ala Val Thr Ala Cys Ala Val Thr Ser Leu Ile Lys Asp Leu 
                85                  90                  95      


Ser Ile Ser Asp His Asn Gly Asn Pro Ser Ala Pro Pro Ser Lys Arg 
            100                 105                 110         


Gln Cys Arg Ser Leu Ser Phe Ser Asp Glu Met Ser Ser Cys Arg Thr 
        115                 120                 125             


Ser Trp Arg Pro Leu Gly Ser Lys Val Trp Thr Pro Val Glu Lys Arg 
    130                 135                 140                 


Arg Cys Tyr Ser Gly Gly Ser Val Gln Arg Tyr Ser Asn Gly Phe Ser 
145                 150                 155                 160 


Thr Met Gln Arg Ser Ser Ser Phe Ser Leu Pro Ser Arg Ala Asn Val 
                165                 170                 175     


Leu Ser Ser Pro Cys Asp Gln Ala Gly Leu His His Arg Phe Gly Gly 
            180                 185                 190         


Gln Pro Cys Gln Gly Val Pro Gly Ser Ala Pro Cys Gly Gln Ala Gly 
        195                 200                 205             


Asp Thr Trp Ser Pro Asp Leu His Pro Val Gly Gly Gly Arg Leu Asp 
    210                 215                 220                 


Leu Gln Arg Ser Leu Ser Cys Ser His Glu Gln Phe Ser Phe Val Glu 
225                 230                 235                 240 


Tyr Cys Pro Pro Ser Ala Asn Ser Thr Pro Ala Ser Thr Pro Glu Leu 
                245                 250                 255     


Ala Arg Arg Ser Ser Gly Leu Ser Arg Ser Arg Ser Gln Pro Cys Val 
            260                 265                 270         


Leu Asn Asp Lys Lys Val Gly Val Lys Arg Arg Arg Pro Glu Glu Val 
        275                 280                 285             


Gln Glu Gln Arg Pro Ser Leu Asp Leu Ala Lys Met Ala Gln Asn Cys 
    290                 295                 300                 


Gln Thr Phe Ser Ser Leu Ser Cys Leu Ser Ala Gly Thr Glu Asp Cys 
305                 310                 315                 320 


Gly Pro Gln Ser Pro Phe Ala Arg His Val Ser Asn Thr Arg Ala Trp 
                325                 330                 335     


Thr Ala Leu Leu Ser Ala Ser Gly Pro Gly Gly Arg Thr Pro Ala Gly 
            340                 345                 350         


Thr Pro Val Pro Glu Pro Leu Pro Pro Ser Phe Asp Asp His Leu Ala 
        355                 360                 365             


Cys Gln Glu Asp Leu Ser Cys Glu Glu Ser Asp Ser Cys Ala Leu Asp 
    370                 375                 380                 


Glu Asp Cys Gly Arg Arg Ala Glu Pro Ala Ala Ala Trp Arg Asp Arg 
385                 390                 395                 400 


Gly Ala Pro Gly Asn Ser Leu Cys Ser Leu Asp Gly Glu Leu Asp Ile 
                405                 410                 415     


Glu Gln Ile Glu Lys Asn 
            420         


<210>  3859
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM57A__Homo_sapiens__NP_079068

<400>  3859

Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe 
1               5                   10                  15      


Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg 
            20                  25                  30          


Thr Asp Cys Val Met Ile Ser Thr Arg Leu Val Ser Ser Val His Ala 
        35                  40                  45              


Val Leu Ala Thr Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp 
    50                  55                  60                  


Val Ile Thr Gly Arg His Trp Leu Ala Arg Glu Tyr Val Trp Phe Leu 
65                  70                  75                  80  


Ile Pro Tyr Met Ile Tyr Asp Ser Tyr Ala Met Tyr Leu Cys Glu Trp 
                85                  90                  95      


Cys Arg Thr Arg Asp Gln Asn Arg Ala Pro Ser Leu Thr Leu Arg Asn 
            100                 105                 110         


Phe Leu Ser Arg Asn Arg Leu Met Ile Thr His His Ala Val Ile Leu 
        115                 120                 125             


Phe Val Leu Val Pro Val Ala Gln Arg Leu Arg Gly Asp Leu Gly Asp 
    130                 135                 140                 


Phe Phe Val Gly Cys Ile Phe Thr Ala Glu Leu Ser Thr Pro Phe Val 
145                 150                 155                 160 


Ser Leu Gly Arg Val Leu Ile Gln Leu Lys Gln Gln His Thr Leu Leu 
                165                 170                 175     


Tyr Lys Val Asn Gly Ile Leu Thr Leu Ala Thr Phe Leu Ser Cys Arg 
            180                 185                 190         


Ile Leu Leu Phe Pro Phe Met Tyr Trp Ser Tyr Gly Arg Gln Gln Gly 
        195                 200                 205             


Leu Ser Leu Leu Gln Val Pro Phe Ser Ile Pro Phe Tyr Cys Asn Val 
    210                 215                 220                 


Ala Asn Ala Phe Leu Val Ala Pro Gln Ile Tyr Trp Phe Cys Leu Leu 
225                 230                 235                 240 


Cys Arg Lys Ala Val Arg Leu Phe Asp Thr Pro Gln Ala Lys Lys Asp 
                245                 250                 255     


Gly 
    


<210>  3860
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM58A__Homo_sapiens__NP_001124469

<400>  3860

Met Glu Ala Pro Glu Gly Gly Gly Gly Gly Pro Ala Ala Arg Gly Pro 
1               5                   10                  15      


Glu Gly Gln Pro Ala Pro Glu Ala Arg Val His Phe Arg Val Ala Arg 
            20                  25                  30          


Phe Ile Met Glu Ala Gly Val Lys Leu Gly Met Arg Ser Ile Pro Ile 
        35                  40                  45              


Ala Thr Ala Cys Thr Ile Tyr His Lys Phe Phe Cys Glu Thr Asn Leu 
    50                  55                  60                  


Asp Ala Tyr Asp Pro Tyr Leu Ile Ala Met Ser Ser Ile Tyr Leu Ala 
65                  70                  75                  80  


Gly Lys Val Glu Glu Gln His Leu Arg Thr Arg Asp Ile Ile Asn Val 
                85                  90                  95      


Ser Asn Arg Tyr Phe Asn Pro Ser Gly Glu Pro Leu Glu Leu Asp Ser 
            100                 105                 110         


Arg Phe Trp Glu Leu Arg Asp Ser Ile Val Gln Cys Glu Leu Leu Met 
        115                 120                 125             


Leu Arg Val Leu Arg Phe Gln Val Ser Phe Gln His Pro His Lys Tyr 
    130                 135                 140                 


Leu Leu His Tyr Leu Val Ser Leu Gln Asn Trp Leu Asn Arg His Ser 
145                 150                 155                 160 


Trp Gln Arg Thr Pro Val Ala Val Thr Ala Trp Ala Leu Leu Arg Asp 
                165                 170                 175     


Ser Tyr His Gly Ala Leu Cys Leu Arg Phe Gln Ala Gln His Ile Ala 
            180                 185                 190         


Val Ala Val Leu Tyr Leu Ala Leu Gln Val Tyr Gly Val Glu Val Pro 
        195                 200                 205             


Ala Glu Val Glu Ala Glu Lys Pro Trp Trp Gln Ile Tyr Thr Met Asp 
    210                 215                 220                 


Thr Glu Ile Pro 
225             


<210>  3861
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM60A__Homo_sapiens__NP_001129284

<400>  3861

Met Phe Gly Phe His Lys Pro Lys Met Tyr Arg Ser Ile Glu Gly Cys 
1               5                   10                  15      


Cys Ile Cys Arg Ala Lys Ser Ser Ser Ser Arg Phe Thr Asp Ser Lys 
            20                  25                  30          


Arg Tyr Glu Lys Asp Phe Gln Ser Cys Phe Gly Leu His Glu Thr Arg 
        35                  40                  45              


Ser Gly Asp Ile Cys Asn Ala Cys Val Leu Leu Val Lys Arg Trp Lys 
    50                  55                  60                  


Lys Leu Pro Ala Gly Ser Lys Lys Asn Trp Asn His Val Val Asp Ala 
65                  70                  75                  80  


Arg Ala Gly Pro Ser Leu Lys Thr Thr Leu Lys Pro Lys Lys Val Lys 
                85                  90                  95      


Thr Leu Ser Gly Asn Arg Ile Lys Ser Asn Gln Ile Ser Lys Leu Gln 
            100                 105                 110         


Lys Glu Phe Lys Arg His Asn Ser Asp Ala His Ser Thr Thr Ser Ser 
        115                 120                 125             


Ala Ser Pro Ala Gln Ser Pro Cys Tyr Ser Asn Gln Ser Asp Asp Gly 
    130                 135                 140                 


Ser Asp Thr Glu Met Ala Ser Gly Ser Asn Arg Thr Pro Val Phe Ser 
145                 150                 155                 160 


Phe Leu Asp Leu Thr Tyr Trp Lys Arg Gln Lys Ile Cys Cys Gly Ile 
                165                 170                 175     


Ile Tyr Lys Gly Arg Phe Gly Glu Val Leu Ile Asp Thr His Leu Phe 
            180                 185                 190         


Lys Pro Cys Cys Ser Asn Lys Lys Ala Ala Ala Glu Lys Pro Glu Glu 
        195                 200                 205             


Gln Gly Pro Glu Pro Leu Pro Ile Ser Thr Gln Glu Trp 
    210                 215                 220     


<210>  3862
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM63B__Homo_sapiens__NP_001035540

<400>  3862

Met Glu Ser Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala 
1               5                   10                  15      


Ala Gly Pro Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu 
            20                  25                  30          


Thr Arg Leu Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr 
        35                  40                  45              


Ser Gly Gly Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro 
    50                  55                  60                  


Asp Ser Ala Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser 
65                  70                  75                  80  


Ser Ser Ala Gly Leu Asp Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala 
                85                  90                  95      


Ala Ala Glu Ala Pro Leu Arg Gly Gln Tyr Lys Val Thr Ala Ser Pro 
            100                 105                 110         


Glu Thr Ala Val Ala Gly Val Gly His Glu Leu Gly Thr Ala Gly Asp 
        115                 120                 125             


Ala Gly Ala Arg Pro Asp Leu Ala Gly Thr Cys Gln Ala Glu Leu Thr 
    130                 135                 140                 


Ala Ala Gly Ser Glu Glu Pro Ser Ser Ala Gly Gly Leu Ser Ser Ser 
145                 150                 155                 160 


Cys Ser Asp Pro Ser Pro Pro Gly Glu Ser Pro Ser Leu Asp Ser Leu 
                165                 170                 175     


Glu Ser Phe Ser Asn Leu His Ser Phe Pro Ser Ser Cys Glu Phe Asn 
            180                 185                 190         


Ser Glu Glu Gly Ala Glu Asn Arg Val Pro Glu Glu Glu Glu Gly Ala 
        195                 200                 205             


Ala Val Leu Pro Gly Ala Val Pro Leu Cys Lys Glu Glu Glu Gly Glu 
    210                 215                 220                 


Glu Thr Ala Gln Val Leu Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln 
225                 230                 235                 240 


Ser Val Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro 
                245                 250                 255     


Ile Ile Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu 
            260                 265                 270         


Asn Val Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu 
        275                 280                 285             


Ile Ile Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu 
    290                 295                 300                 


Asp Ala Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu 
305                 310                 315                 320 


Gln Asn Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly 
                325                 330                 335     


Leu Asp Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr 
            340                 345                 350         


Pro Glu Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly 
        355                 360                 365             


Trp Leu Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn 
    370                 375                 380                 


Cys Ser Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser 
385                 390                 395                 400 


Asp Asn Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu 
                405                 410                 415     


Asn Asn Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr 
            420                 425                 430         


Ser Thr Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His 
        435                 440                 445             


Phe Ser Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr 
    450                 455                 460                 


Asp Gln Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His 
465                 470                 475                 480 


Asn Val Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg 
                485                 490                 495     


Pro Pro Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile 
            500                 505                 510         


Asp Gln Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser 
        515                 520                 525             


Gln Glu Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu 
    530                 535                 540                 


Leu Ala Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr 
545                 550                 555                 560 


Tyr Gln Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr 
                565                 570                 575     


Gln Ala Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg 
            580                 585                 590         


Gln Ser Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp 
        595                 600                 605             


Lys Glu Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
    610                 615                 620     


<210>  3863
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM64A__Homo_sapiens__NP_001182157

<400>  3863

Met Ala Ser Arg Trp Gln Asn Met Gly Thr Ser Val Arg Arg Arg Ser 
1               5                   10                  15      


Leu Gln His Gln Glu Gln Leu Glu Asp Ser Lys Glu Leu Gln Pro Val 
            20                  25                  30          


Val Ser His Gln Glu Thr Ser Val Gly Ala Leu Gly Ser Leu Cys Arg 
        35                  40                  45              


Gln Phe Gln Arg Arg Leu Pro Leu Arg Ala Val Asn Leu Asn Leu Arg 
    50                  55                  60                  


Ala Gly Pro Ser Trp Lys Arg Leu Glu Thr Pro Glu Pro Gly Gln Gln 
65                  70                  75                  80  


Gly Leu Gln Ala Ala Ala Arg Ser Ala Lys Ser Ala Leu Gly Ala Val 
                85                  90                  95      


Ser Gln Arg Ile Gln Glu Ser Cys Gln Ser Gly Thr Lys Trp Leu Val 
            100                 105                 110         


Glu Thr Gln Val Lys Ala Arg Arg Arg Lys Arg Gly Ala Gln Lys Gly 
        115                 120                 125             


Ser Gly Ser Pro Thr His Ser Leu Ser Gln Lys Ser Thr Arg Leu Ser 
    130                 135                 140                 


Gly Ala Ala Pro Ala His Ser Ala Ala Asp Pro Trp Glu Lys Glu His 
145                 150                 155                 160 


His Arg Leu Ser Val Arg Met Gly Ser His Ala His Pro Leu Arg Arg 
                165                 170                 175     


Ser Arg Arg Glu Ala Ala Phe Arg Ser Pro Tyr Ser Ser Thr Glu Pro 
            180                 185                 190         


Leu Cys Ser Pro Ser Glu Ser Asp Ser Asp Leu Glu Pro Val Gly Ala 
        195                 200                 205             


Gly Ile Gln His Leu Gln Lys Leu Ser Gln Glu Leu Asp Glu Ala Ile 
    210                 215                 220                 


Met Ala Glu Glu Arg Lys Gln Ala Leu Ser Asp Arg Gln Gly Phe Ile 
225                 230                 235                 240 


Leu Lys Asp Val Tyr Ala Ser Pro 
                245             


<210>  3864
<211>  1047
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM65B__Homo_sapiens__NP_001273374

<400>  3864

Met Gln Phe Phe Asp Ala Glu Glu Leu Leu Val Asp Glu Glu Asp Asp 
1               5                   10                  15      


Val Phe Gly Glu Gly Leu Pro Thr Arg Leu Pro Glu Ile Met Leu Val 
            20                  25                  30          


Gly Ser Gln Ser Phe Ser Pro Gly Gly Pro Asn Gly Ile Ile Arg Ser 
        35                  40                  45              


Gln Ser Phe Ala Gly Phe Ser Gly Leu Gln Glu Arg Arg Ser Arg Cys 
    50                  55                  60                  


Asn Ser Phe Ile Glu Asn Ser Ser Ala Leu Lys Lys Pro Gln Ala Lys 
65                  70                  75                  80  


Leu Lys Lys Met His Asn Leu Gly His Lys Asn Asn Asn Pro Pro Lys 
                85                  90                  95      


Glu Pro Gln Pro Lys Arg Val Glu Glu Val Tyr Arg Ala Leu Lys Asn 
            100                 105                 110         


Gly Leu Asp Glu Tyr Leu Glu Val His Gln Thr Glu Leu Asp Lys Leu 
        115                 120                 125             


Thr Ala Gln Leu Lys Asp Met Lys Arg Asn Ser Arg Leu Gly Val Leu 
    130                 135                 140                 


Tyr Asp Leu Asp Lys Gln Ile Lys Thr Ile Glu Arg Tyr Met Arg Arg 
145                 150                 155                 160 


Leu Glu Phe His Ile Ser Lys Val Asp Glu Leu Tyr Glu Ala Tyr Cys 
                165                 170                 175     


Ile Gln Arg Arg Leu Gln Asp Gly Ala Ser Lys Met Lys Gln Ala Phe 
            180                 185                 190         


Ala Thr Ser Pro Ala Ser Lys Ala Ala Arg Glu Ser Leu Thr Glu Ile 
        195                 200                 205             


Asn Arg Ser Phe Lys Glu Tyr Thr Glu Asn Met Cys Thr Ile Glu Val 
    210                 215                 220                 


Glu Leu Glu Asn Leu Leu Gly Glu Phe Ser Ile Lys Met Lys Gly Leu 
225                 230                 235                 240 


Ala Gly Phe Ala Arg Leu Cys Pro Gly Asp Gln Tyr Glu Ile Phe Met 
                245                 250                 255     


Lys Tyr Gly Arg Gln Arg Trp Lys Leu Lys Gly Lys Ile Glu Val Asn 
            260                 265                 270         


Gly Lys Gln Ser Trp Asp Gly Glu Glu Thr Val Phe Leu Pro Leu Ile 
        275                 280                 285             


Val Gly Phe Ile Ser Ile Lys Val Thr Glu Leu Lys Gly Leu Ala Thr 
    290                 295                 300                 


His Ile Leu Val Gly Ser Val Thr Cys Glu Thr Lys Glu Leu Phe Ala 
305                 310                 315                 320 


Ala Arg Pro Gln Val Val Ala Val Asp Ile Asn Asp Leu Gly Thr Ile 
                325                 330                 335     


Lys Leu Asn Leu Glu Ile Thr Trp Tyr Pro Phe Asp Val Glu Asp Met 
            340                 345                 350         


Thr Ala Ser Ser Gly Ala Gly Asn Lys Ala Ala Ala Leu Gln Arg Arg 
        355                 360                 365             


Met Ser Met Tyr Ser Gln Gly Thr Pro Glu Thr Pro Thr Phe Lys Asp 
    370                 375                 380                 


His Ser Phe Phe Ser Asn Leu Pro Asp Asp Ile Phe Glu Asn Gly Lys 
385                 390                 395                 400 


Ala Ala Glu Glu Lys Met Pro Leu Ser Leu Ser Phe Ser Asp Leu Pro 
                405                 410                 415     


Asn Gly Asp Cys Ala Leu Thr Ser His Ser Thr Gly Ser Pro Ser Asn 
            420                 425                 430         


Ser Thr Asn Pro Glu Ile Thr Ile Thr Pro Ala Glu Phe Asn Leu Ser 
        435                 440                 445             


Ser Leu Ala Ser Gln Asn Glu Gly Met Asp Asp Thr Ser Ser Ala Ser 
    450                 455                 460                 


Ser Arg Asn Ser Leu Gly Glu Gly Gln Glu Pro Lys Ser His Leu Lys 
465                 470                 475                 480 


Glu Glu Asp Pro Glu Glu Pro Arg Lys Pro Ala Ser Ala Pro Ser Glu 
                485                 490                 495     


Ala Cys Arg Arg Gln Ser Ser Gly Ala Gly Ala Glu His Leu Phe Leu 
            500                 505                 510         


Glu Asn Asp Val Ala Glu Ala Leu Leu Gln Glu Ser Glu Glu Ala Ser 
        515                 520                 525             


Glu Leu Lys Pro Val Glu Leu Asp Thr Ser Glu Gly Asn Ile Thr Lys 
    530                 535                 540                 


Gln Leu Val Lys Arg Leu Thr Ser Ala Glu Val Pro Met Ala Thr Asp 
545                 550                 555                 560 


Arg Leu Leu Ser Glu Gly Ser Val Gly Gly Glu Ser Glu Gly Cys Arg 
                565                 570                 575     


Ser Phe Leu Asp Gly Ser Leu Glu Asp Ala Phe Asn Gly Leu Leu Leu 
            580                 585                 590         


Ala Leu Glu Pro His Lys Glu Gln Tyr Lys Glu Phe Gln Asp Leu Asn 
        595                 600                 605             


Gln Glu Val Met Asn Leu Asp Asp Ile Leu Lys Cys Lys Pro Ala Val 
    610                 615                 620                 


Ser Arg Ser Arg Ser Ser Ser Leu Ser Leu Thr Val Glu Ser Ala Leu 
625                 630                 635                 640 


Glu Ser Phe Asp Phe Leu Asn Thr Ser Asp Phe Asp Glu Glu Glu Asp 
                645                 650                 655     


Gly Asp Glu Val Cys Asn Val Gly Gly Gly Ala Asp Ser Val Phe Ser 
            660                 665                 670         


Asp Thr Glu Thr Glu Lys His Ser Tyr Arg Ser Val His Pro Glu Ala 
        675                 680                 685             


Arg Gly His Leu Ser Glu Ala Leu Thr Glu Asp Thr Gly Val Gly Thr 
    690                 695                 700                 


Ser Val Ala Gly Ser Pro Leu Pro Leu Thr Thr Gly Asn Glu Ser Leu 
705                 710                 715                 720 


Asp Ile Thr Ile Val Arg His Leu Gln Tyr Cys Thr Gln Leu Val Gln 
                725                 730                 735     


Gln Ile Val Phe Ser Ser Lys Thr Pro Phe Val Ala Arg Ser Leu Leu 
            740                 745                 750         


Glu Lys Leu Ser Arg Gln Ile Gln Val Met Glu Lys Leu Ala Ala Val 
        755                 760                 765             


Ser Asp Glu Asn Ile Gly Asn Ile Ser Ser Val Val Glu Ala Ile Pro 
    770                 775                 780                 


Glu Phe His Lys Lys Leu Ser Leu Leu Ser Phe Trp Thr Lys Cys Cys 
785                 790                 795                 800 


Ser Pro Val Gly Val Tyr His Ser Pro Ala Asp Arg Val Met Lys Gln 
                805                 810                 815     


Leu Glu Ala Ser Phe Ala Arg Thr Val Asn Lys Glu Tyr Pro Gly Leu 
            820                 825                 830         


Ala Asp Pro Val Phe Arg Thr Leu Val Ser Gln Ile Leu Asp Arg Ala 
        835                 840                 845             


Glu Pro Leu Leu Ser Ser Ser Leu Ser Ser Glu Val Val Thr Val Phe 
    850                 855                 860                 


Gln Tyr Tyr Ser Tyr Phe Thr Ser His Gly Val Ser Asp Leu Glu Ser 
865                 870                 875                 880 


Tyr Leu Ser Gln Leu Ala Arg Gln Val Ser Met Val Gln Thr Leu Gln 
                885                 890                 895     


Ser Leu Arg Asp Glu Lys Leu Leu Gln Thr Met Ser Asp Leu Ala Pro 
            900                 905                 910         


Ser Asn Leu Leu Ala Gln Gln Glu Val Leu Arg Thr Leu Ala Leu Leu 
        915                 920                 925             


Leu Thr Arg Glu Asp Asn Glu Val Ser Glu Ala Val Thr Leu Tyr Leu 
    930                 935                 940                 


Ala Ala Ala Ser Lys Asn Gln His Phe Arg Glu Lys Ala Leu Leu Tyr 
945                 950                 955                 960 


Tyr Cys Glu Ala Leu Thr Lys Thr Asn Leu Gln Leu Gln Lys Ala Ala 
                965                 970                 975     


Cys Leu Ala Leu Lys Ile Leu Glu Ala Thr Glu Ser Ile Lys Met Leu 
            980                 985                 990         


Val Thr Leu Cys Gln Ser Asp Thr  Glu Glu Ile Arg Asn  Val Ala Ser 
        995                 1000                 1005             


Glu Thr  Leu Leu Ser Leu Gly  Glu Asp Gly Arg Leu  Ala Tyr Glu 
    1010                 1015                 1020             


Gln Leu  Asp Lys Phe Pro Arg  Asp Cys Val Lys Val  Gly Gly Arg 
    1025                 1030                 1035             


His Gly  Thr Glu Val Ala Thr  Ala Phe 
    1040                 1045         


<210>  3865
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM69C__Homo_sapiens__NP_001037834

<400>  3865

Met Ala Arg Ala Ala Gly Ala Arg Gly Pro Ala Gly Trp Cys Arg Arg 
1               5                   10                  15      


Arg Gly Arg Cys Gly Arg Gly Thr Leu Leu Ala Phe Ala Ala Trp Thr 
            20                  25                  30          


Ala Gly Trp Val Leu Ala Ala Ala Leu Leu Leu Arg Ala His Pro Gly 
        35                  40                  45              


Val Leu Ser Glu Arg Cys Thr Asp Glu Lys Ser Arg Arg Ile Leu Ala 
    50                  55                  60                  


Ala Leu Cys Gln Asp Tyr Gln Gly Gly Thr Leu Ala Gly Asp Leu Cys 
65                  70                  75                  80  


Glu Asp Leu Cys Val Ala Gly Glu Leu Leu Phe Gln Arg Cys Leu His 
                85                  90                  95      


Tyr Asn Arg Gly Lys Lys Val Leu Gln Ala Asp Trp Arg Gly Arg Pro 
            100                 105                 110         


Val Val Leu Lys Ser Lys Glu Glu Ala Phe Ser Ser Phe Pro Pro Leu 
        115                 120                 125             


Ser Leu Leu Glu Glu Glu Ala Gly Glu Gly Gly Gln Asp Met Pro Glu 
    130                 135                 140                 


Ala Glu Leu Leu Leu Met Val Ala Gly Glu Val Lys Ser Ala Leu Gly 
145                 150                 155                 160 


Leu Glu Leu Ser Asn Ser Ser Leu Gly Pro Trp Trp Pro Gly Arg Arg 
                165                 170                 175     


Gly Pro Arg Trp Arg Gly Gln Leu Ala Ser Leu Trp Ala Leu Leu Gln 
            180                 185                 190         


Gln Glu Glu Tyr Val Tyr Phe Ser Leu Leu Gln Asp Leu Ser Pro His 
        195                 200                 205             


Val Leu Pro Val Leu Gly Ser Cys Gly His Phe Tyr Ala Val Glu Phe 
    210                 215                 220                 


Leu Ala Ala Gly Ser Pro His His Arg Ala Leu Phe Pro Leu Asp Arg 
225                 230                 235                 240 


Ala Pro Gly Ala Pro Gly Gly Gly Gln Ala Lys Ala Ile Ser Asp Ile 
                245                 250                 255     


Ala Leu Ser Phe Leu Asp Met Val Asn His Phe Asp Ser Asp Phe Ser 
            260                 265                 270         


His Arg Leu His Leu Cys Asp Ile Lys Pro Glu Asn Phe Ala Ile Arg 
        275                 280                 285             


Ser Asp Phe Thr Val Val Ala Ile Asp Val Asp Met Ala Phe Phe Glu 
    290                 295                 300                 


Pro Lys Met Arg Glu Ile Leu Glu Gln Asn Cys Thr Gly Asp Glu Asp 
305                 310                 315                 320 


Cys Asn Phe Phe Asp Cys Phe Ser Arg Cys Asp Leu Arg Val Asn Lys 
                325                 330                 335     


Cys Gly Ala Gln Arg Val Asn Asn Asn Leu Gln Val Ile Cys Asp Lys 
            340                 345                 350         


Ile Phe Arg His Trp Phe Ser Ala Pro Leu Lys Ser Ser Ala Val Ser 
        355                 360                 365             


Phe Gln Leu Gln Leu Gln Leu Gln Glu Ala Val Gln Glu Cys Ala Asp 
    370                 375                 380                 


Pro Gly Val Pro Ser Gly Asn Thr Arg Arg Ala Ala Ser Ser Val Phe 
385                 390                 395                 400 


Trp Lys Leu Arg Gln Leu Leu Gln Ala Thr Leu Arg Glu Leu Gln Glu 
                405                 410                 415     


Ala Glu Lys 
            


<210>  3866
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM71F1__Homo_sapiens__NP_115988

<400>  3866

Met Leu Ser Ser Phe Pro His Arg Lys Thr Trp Arg Lys Ser Lys Lys 
1               5                   10                  15      


Thr Val Lys Val Thr Arg Ser Tyr Pro Thr Phe Pro Ser Leu Asn Ala 
            20                  25                  30          


Trp Glu Glu Phe Arg Gly Leu Leu Pro Val Asp Gly Glu Pro Asn Pro 
        35                  40                  45              


Gly Ala Gly Leu Gly Val Glu Glu Gly Leu Leu Cys Arg Val Val His 
    50                  55                  60                  


Ser Pro Glu Phe Asn Leu Phe Leu Asp Ser Val Val Phe Glu Ser Asn 
65                  70                  75                  80  


Phe Ile Gln Val Lys Arg Gly Arg Asn Trp Arg Asp Val Tyr Lys Ala 
                85                  90                  95      


Ser Asn Thr Met Ala Leu Gly Val Thr Ser Ser Val Pro Cys Leu Pro 
            100                 105                 110         


Leu Pro Asn Ile Leu Leu Met Ala Ser Val Lys Trp His Gln Gly Gln 
        115                 120                 125             


Asn Gln Thr Trp Asn Arg Pro Ser Ile Ala Pro Asn Ile Phe Leu Lys 
    130                 135                 140                 


Arg Ile Leu Pro Leu Arg Phe Val Glu Leu Gln Val Cys Asp His Tyr 
145                 150                 155                 160 


Gln Arg Ile Leu Gln Leu Arg Thr Val Thr Glu Lys Ile Tyr Tyr Leu 
                165                 170                 175     


Lys Leu His Pro Asp His Pro Glu Thr Val Phe His Phe Trp Ile Arg 
            180                 185                 190         


Leu Val Gln Ile Leu Gln Lys Gly Leu Ser Ile Thr Thr Lys Asp Pro 
        195                 200                 205             


Arg Ile Leu Val Thr His Cys Leu Val Pro Lys Asn Cys Ser Ser Pro 
    210                 215                 220                 


Ser Gly Asp Ser Lys Leu Val Gln Lys Lys Leu Gln Ala Ser Gln Pro 
225                 230                 235                 240 


Ser Glu Ser Leu Ile Gln Leu Met Thr Lys Gly Glu Ser Glu Ala Leu 
                245                 250                 255     


Ser Gln Ile Phe Ala Asp Leu His Gln Gln Asn Gln Leu Ser Phe Arg 
            260                 265                 270         


Ser Ser Arg Lys Val Glu Thr Asn Lys Asn Ser Ser Gly Lys Asp Ser 
        275                 280                 285             


Ser Arg Glu Asp Ser Ile Pro Cys Thr Cys Asp Leu Arg Trp Arg Ala 
    290                 295                 300                 


Ser Phe Thr Tyr Gly Glu Trp Glu Arg Glu Asn Pro Ser Gly Leu Gln 
305                 310                 315                 320 


Pro Leu Ser Leu Leu Ser Thr Leu Ala Ala Ser Thr Gly Pro Gln Leu 
                325                 330                 335     


Ala Pro Pro Ile Gly Asn Ser Ile 
            340                 


<210>  3867
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM71F2__Homo_sapiens__NP_001012457

<400>  3867

Met Ser Lys Ile Arg Gly Leu Pro Pro Glu Val Arg Glu Pro Gly Pro 
1               5                   10                  15      


Gly Val Glu Leu Gly Val Glu Asn Gly Leu Leu Cys Gln Leu Ile His 
            20                  25                  30          


Ser Pro Glu Phe Asn Leu Phe Ser Asn Ser Val Val Phe Glu Ser Asn 
        35                  40                  45              


Phe Ile Gln Thr His Val Pro Glu Ala Asp Phe Gln Val Thr Lys Pro 
    50                  55                  60                  


Gly Asn Trp Arg Asp Val Cys Glu Gly Ser Ala Thr Val Ile Leu Gly 
65                  70                  75                  80  


Val Thr Ser Ser Val Pro Ser Leu Pro Leu Pro Asn Val Leu Leu Met 
                85                  90                  95      


Ala Asn Val Thr Trp Pro Gln Gly Pro Phe Thr Thr Trp Ser Thr Pro 
            100                 105                 110         


Gly Asp Ala Pro Val Ile Asn Leu Ser Arg Leu Leu Pro Leu Lys Tyr 
        115                 120                 125             


Val Glu Leu Arg Ile Tyr Asp Arg Leu Gln Arg Ile Leu Arg Val Arg 
    130                 135                 140                 


Thr Val Thr Glu Lys Ile Tyr Tyr Leu Lys Leu His Glu Lys His Pro 
145                 150                 155                 160 


Glu Ile Val Phe Gln Phe Trp Val Arg Leu Val Lys Ile Leu Gln Lys 
                165                 170                 175     


Gly Leu Ser Ile Thr Thr Lys Asp Pro Arg Ile Lys Phe Thr His Cys 
            180                 185                 190         


Leu Val Pro Lys Met Pro Thr Asn Ser Thr Glu Thr Thr Pro Glu Asn 
        195                 200                 205             


Ser Leu Leu Ser Ser Pro Gln Pro Ser Glu Pro Leu Val Leu Leu Ala 
    210                 215                 220                 


Ala Glu Gln Thr Ser Gly Ser Phe Ser Gln Leu Ser Gly Lys Pro Gln 
225                 230                 235                 240 


Leu Thr Ala Asp Arg Asn Asn Asp Thr Ala Ile Glu Ile Asp Asn Cys 
                245                 250                 255     


Ser Ser Tyr Lys Ile Pro Ser Pro Val Ala Ser Pro Ile Asn Leu Asn 
            260                 265                 270         


Ile Pro Met Arg Ala Ala Leu Ser His Ser Leu Trp Glu Gln Glu Asp 
        275                 280                 285             


Trp Asn Glu His Leu Leu Gln Val His Ile Ala Ser Tyr Leu Gly Glu 
    290                 295                 300                 


His Phe Leu Gly Ala 
305                 


<210>  3868
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM72B__Homo_sapiens__NP_001307078

<400>  3868

Met Ser Thr Asn Ile Cys Ser Phe Lys Asp Ser Ala Val Asp Phe Thr 
1               5                   10                  15      


Gly Arg Cys Tyr Phe Thr Lys Ile Cys Lys Cys Lys Leu Lys Asp Ile 
            20                  25                  30          


Ala Cys Leu Lys Cys Gly Asn Ile Val Gly Tyr His Val Ile Val Pro 
        35                  40                  45              


Cys Ser Ser Cys Leu Pro Ser Cys Asn Asn Gly His Phe Trp Met Phe 
    50                  55                  60                  


His Ser Gln Ala Val Tyr Asp Ile Asn Arg Leu Asp Ser Thr Gly Val 
65                  70                  75                  80  


Asn Ile Leu Leu Trp Gly Asn Leu Pro Glu Ile Glu Glu Ser Thr Asp 
                85                  90                  95      


Glu Asp Val Leu Asn Ile Ser Ala Glu Glu Cys Ile Arg 
            100                 105                 


<210>  3869
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM78B__Homo_sapiens__NP_001017961

<400>  3869

Met Gly Cys Ile Gln Ser Ile Thr Cys Lys Ala Arg Ile Arg Arg Glu 
1               5                   10                  15      


Asn Ile Val Val Tyr Asp Val Cys Ala Thr Ile Asp Gln Cys Pro Thr 
            20                  25                  30          


Arg Ile Glu Glu Thr Ser Pro Ile Val Leu Arg Tyr Lys Thr Pro Tyr 
        35                  40                  45              


Phe Lys Ala Ser Ala Arg Val Val Met Pro Pro Ile Pro Arg His Glu 
    50                  55                  60                  


Thr Trp Val Val Gly Trp Ile Gln Ala Cys Asn Gln Met Glu Phe Phe 
65                  70                  75                  80  


Asn Thr Tyr Ser Asp Leu Gly Met Ser Ser Trp Glu Leu Pro Asp Leu 
                85                  90                  95      


Arg Glu Gly Arg Val Lys Ala Ile Ser Asp Ser Asp Gly Val Ser Tyr 
            100                 105                 110         


Pro Trp Tyr Gly Asn Thr Thr Glu Thr Val Thr Leu Val Gly Pro Thr 
        115                 120                 125             


Asn Lys Ile Ser Arg Phe Ser Val Ser Met Asn Asp Asn Phe Tyr Pro 
    130                 135                 140                 


Ser Val Thr Trp Ala Val Pro Val Ser Asp Ser Asn Val Pro Leu Leu 
145                 150                 155                 160 


Thr Arg Ile Lys Arg Asp Gln Ser Phe Thr Thr Trp Leu Val Ala Met 
                165                 170                 175     


Asn Thr Thr Thr Lys Glu Lys Ile Ile Leu Gln Thr Ile Lys Trp Arg 
            180                 185                 190         


Met Arg Val Asp Ile Glu Val Asp Pro Leu Gln Leu Leu Gly Gln Arg 
        195                 200                 205             


Ala Arg Leu Val Gly Arg Thr Gln Gln Glu Gln Pro Arg Ile Leu Ser 
    210                 215                 220                 


Arg Met Glu Pro Ile Pro Pro Asn Ala Leu Val Lys Pro Asn Ala Asn 
225                 230                 235                 240 


Asp Ala Gln Val Leu Met Trp Arg Pro Lys Arg Gly Pro Pro Leu Val 
                245                 250                 255     


Val Ile Pro Pro Lys 
            260     


<210>  3870
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM81B__Homo_sapiens__NP_689761

<400>  3870

Met Gln Leu Gln Phe Leu Gly Thr Leu Ala Ser Ser Glu Lys Arg Lys 
1               5                   10                  15      


Lys Ser Gln Arg Leu Phe Phe Lys Asn Ile Lys Ser Thr Lys Asn Lys 
            20                  25                  30          


Ala Gly Lys Ala Ser Ile Met Ser Ser Asp Thr Asn Val Asn Lys Ser 
        35                  40                  45              


Ala Ser Pro Thr Ala Thr Ala Glu Glu Gln Pro Val Glu Pro Asp Gly 
    50                  55                  60                  


Pro Leu Pro Gly Ser Asp Asn Asn Gln Glu Lys Lys Val Arg Leu Ser 
65                  70                  75                  80  


Pro Ala Lys Met Ser Thr Lys Asn Ser Thr Asp Leu Val Glu Tyr Val 
                85                  90                  95      


Asp Lys Ser His Ala Phe Leu Pro Ile Ile Pro Asn Thr Gln Arg Gly 
            100                 105                 110         


Gln Leu Glu Asp Arg Leu Asn Asn Gln Ala Arg Thr Ile Ala Phe Leu 
        115                 120                 125             


Leu Glu Gln Ala Phe Arg Ile Lys Glu Asp Ile Ser Ala Cys Leu Gln 
    130                 135                 140                 


Gly Thr His Gly Phe Arg Lys Glu Glu Ser Leu Ala Arg Lys Leu Leu 
145                 150                 155                 160 


Glu Ser His Ile Gln Thr Ile Thr Ser Ile Val Lys Lys Leu Ser Gln 
                165                 170                 175     


Asn Ile Glu Ile Leu Glu Asp Gln Ile Arg Ala Arg Asp Gln Ala Ala 
            180                 185                 190         


Thr Gly Thr Asn Phe Ala Val His Glu Ile Asn Ile Lys His Leu Gln 
        195                 200                 205             


Gly Val Gly Asp Leu Arg Gly Arg Val Ala Arg Cys Asp Ser Ser Ile 
    210                 215                 220                 


Val Lys Leu Ser Gly Asp Ile His Leu Phe Arg Gln Glu His Arg Gln 
225                 230                 235                 240 


Ile Glu Lys Ala Ile Gln Glu Phe Val Pro Ala Leu Glu Thr Leu Ser 
                245                 250                 255     


Lys Asn Leu Asp Met Lys Val Met Gln Leu Leu Gly Lys Ile Glu Thr 
            260                 265                 270         


Ala Ser Ser Glu Gln Thr Ser Asn Leu Lys Met Val Gln Gly Asp Tyr 
        275                 280                 285             


Arg His Glu Met Asn Leu Leu Glu Phe Lys Phe His Ser Leu Ser Ser 
    290                 295                 300                 


Asn Leu Tyr Glu Glu Val Glu Asn Asn Lys Lys Trp Thr Glu Asn Gln 
305                 310                 315                 320 


Phe Leu Lys Tyr Arg Lys Asp His Leu Gly His Ile Asn Glu Cys Leu 
                325                 330                 335     


Lys Val Leu Gln Glu Lys Leu Glu Lys Ser Glu Asn Lys Met Glu Glu 
            340                 345                 350         


Lys Leu Leu Gln Leu Ser Ser Lys Val Glu Asn Phe Ile Asn Thr Gln 
        355                 360                 365             


Lys Gln Glu Thr Gln Leu Ser Lys Val Lys His Met Glu Asn Lys Leu 
    370                 375                 380                 


Ser Lys Lys Met Glu Gln Met Glu Lys Gln Ile Trp Gly Glu Leu Glu 
385                 390                 395                 400 


Thr Met Gln Asn Glu Tyr Gln Ser Gly Phe Lys Ser Ile His Asp Ser 
                405                 410                 415     


Leu Ser Ser Leu Gln Gln Ile Gln Lys Thr Lys Met Asp Leu Glu Lys 
            420                 425                 430         


Tyr Lys Val Gln Lys Asp Leu Lys Lys Leu Gln Arg Lys Ile Val Glu 
        435                 440                 445             


Leu Gln Glu Val 
    450         


<210>  3871
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM83A__Homo_sapiens__NP_001275516

<400>  3871

Met Ser Arg Ser Arg His Leu Gly Lys Ile Arg Lys Arg Leu Glu Asp 
1               5                   10                  15      


Val Lys Ser Gln Trp Val Arg Pro Ala Arg Ala Asp Phe Ser Asp Asn 
            20                  25                  30          


Glu Ser Ala Arg Leu Ala Thr Asp Ala Leu Leu Asp Gly Gly Ser Glu 
        35                  40                  45              


Ala Tyr Trp Arg Val Leu Ser Gln Glu Gly Glu Val Asp Phe Leu Ser 
    50                  55                  60                  


Ser Val Glu Ala Gln Tyr Ile Gln Ala Gln Ala Arg Glu Pro Pro Cys 
65                  70                  75                  80  


Pro Pro Asp Thr Leu Gly Gly Ala Glu Ala Gly Pro Lys Gly Leu Asp 
                85                  90                  95      


Ser Ser Ser Leu Gln Ser Gly Thr Tyr Phe Pro Val Ala Ser Glu Gly 
            100                 105                 110         


Ser Glu Pro Ala Leu Leu His Ser Trp Ala Ser Ala Glu Lys Pro Tyr 
        115                 120                 125             


Leu Lys Glu Lys Ser Ser Ala Thr Val Tyr Phe Gln Thr Val Lys His 
    130                 135                 140                 


Asn Asn Ile Arg Asp Leu Val Arg Arg Cys Ile Thr Arg Thr Ser Gln 
145                 150                 155                 160 


Asn Ile Ser Ile Arg Ser Val Glu Gly Glu Ile Tyr Cys Ala Lys Ser 
                165                 170                 175     


Gly Arg Lys Phe Ala Gly Gln Ile Arg Glu Lys Phe Ile Ile Ser Asp 
            180                 185                 190         


Trp Arg Phe Val Leu Ser Gly Ser Tyr Ser Phe Thr Trp Leu Cys Gly 
        195                 200                 205             


His Val His Arg Asn Ile Leu Ser Lys Phe Thr Gly Gln Ala Val Glu 
    210                 215                 220                 


Leu Phe Asp Glu Glu Phe Arg His Leu Tyr Ala Ser Ser Lys Pro Val 
225                 230                 235                 240 


Met Gly Leu Lys Ser Pro Arg Leu Val Ala Pro Val Pro Pro Gly Ala 
                245                 250                 255     


Ala Pro Ala Asn Gly Arg Leu Ser Ser Ser Ser Gly Ser Ala Ser Asp 
            260                 265                 270         


Arg Thr Ser Ser Asn Pro Phe Ser Gly Arg Ser Ala Gly Ser His Pro 
        275                 280                 285             


Gly Thr Arg Thr Asp Gly 
    290                 


<210>  3872
<211>  1011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM83B__Homo_sapiens__NP_001010872

<400>  3872

Met Glu Thr Ser Ser Met Leu Ser Ser Leu Asn Asp Glu Cys Lys Ser 
1               5                   10                  15      


Asp Asn Tyr Ile Glu Pro His Tyr Lys Glu Trp Tyr Arg Val Ala Ile 
            20                  25                  30          


Asp Ile Leu Ile Glu His Gly Leu Glu Ala Tyr Gln Glu Phe Leu Val 
        35                  40                  45              


Gln Glu Arg Val Ser Asp Phe Leu Ala Glu Glu Glu Ile Asn Tyr Ile 
    50                  55                  60                  


Leu Lys Asn Val Gln Lys Val Ala Gln Ser Thr Ala His Gly Thr Asp 
65                  70                  75                  80  


Asp Ser Cys Asp Asp Thr Leu Ser Ser Gly Thr Tyr Trp Pro Val Glu 
                85                  90                  95      


Ser Asp Val Glu Ala Pro Asn Leu Asp Leu Gly Trp Pro Tyr Val Met 
            100                 105                 110         


Pro Gly Leu Leu Gly Gly Thr His Ile Asp Leu Leu Phe His Pro Pro 
        115                 120                 125             


Arg Ala His Leu Leu Thr Ile Lys Glu Thr Ile Arg Lys Met Ile Lys 
    130                 135                 140                 


Glu Ala Arg Lys Val Ile Ala Leu Val Met Asp Ile Phe Thr Asp Val 
145                 150                 155                 160 


Asp Ile Phe Lys Glu Ile Val Glu Ala Ser Thr Arg Gly Val Ser Val 
                165                 170                 175     


Tyr Ile Leu Leu Asp Glu Ser Asn Phe Asn His Phe Leu Asn Met Thr 
            180                 185                 190         


Glu Lys Gln Gly Cys Ser Val Gln Arg Leu Arg Asn Ile Arg Val Arg 
        195                 200                 205             


Thr Val Lys Gly Gln Asp Tyr Leu Ser Lys Thr Gly Ala Lys Phe His 
    210                 215                 220                 


Gly Lys Met Glu Gln Lys Phe Leu Leu Val Asp Cys Gln Lys Val Met 
225                 230                 235                 240 


Tyr Gly Ser Tyr Ser Tyr Met Trp Ser Phe Glu Lys Ala His Leu Ser 
                245                 250                 255     


Met Val Gln Ile Ile Thr Gly Gln Leu Val Glu Ser Phe Asp Glu Glu 
            260                 265                 270         


Phe Arg Thr Leu Tyr Ala Arg Ser Cys Val Pro Ser Ser Phe Ala Gln 
        275                 280                 285             


Glu Glu Ser Ala Arg Val Lys His Gly Lys Ala Leu Trp Glu Asn Gly 
    290                 295                 300                 


Thr Tyr Gln His Ser Val Ser Ser Leu Ala Ser Val Ser Ser Gln Arg 
305                 310                 315                 320 


Asn Leu Phe Gly Arg Gln Asp Lys Ile His Lys Leu Asp Ser Ser Tyr 
                325                 330                 335     


Phe Lys Asn Arg Gly Ile Tyr Thr Leu Asn Glu His Asp Lys Tyr Asn 
            340                 345                 350         


Ile Arg Ser His Gly Tyr Lys Pro His Phe Val Pro Asn Phe Asn Gly 
        355                 360                 365             


Pro Asn Ala Ile Arg Gln Phe Gln Pro Asn Gln Ile Asn Glu Asn Trp 
    370                 375                 380                 


Lys Arg His Ser Tyr Ala Gly Glu Gln Pro Glu Thr Val Pro Tyr Leu 
385                 390                 395                 400 


Leu Leu Asn Arg Ala Leu Asn Arg Thr Asn Asn Pro Pro Gly Asn Trp 
                405                 410                 415     


Lys Lys Pro Ser Asp Ser Leu Ser Val Ala Ser Ser Ser Arg Glu Gly 
            420                 425                 430         


Tyr Val Ser His His Asn Thr Pro Ala Gln Ser Phe Ala Asn Arg Leu 
        435                 440                 445             


Ala Gln Arg Lys Thr Thr Asn Leu Ala Asp Arg Asn Ser Asn Val Arg 
    450                 455                 460                 


Arg Ser Phe Asn Gly Thr Asp Asn His Ile Arg Phe Leu Gln Gln Arg 
465                 470                 475                 480 


Met Pro Thr Leu Glu His Thr Thr Lys Ser Phe Leu Arg Asn Trp Arg 
                485                 490                 495     


Ile Glu Ser Tyr Leu Asn Asp His Ser Glu Ala Thr Pro Asp Ser Asn 
            500                 505                 510         


Gly Ser Ala Leu Gly Asp Arg Phe Glu Gly Tyr Asp Asn Pro Glu Asn 
        515                 520                 525             


Leu Lys Ala Asn Ala Leu Tyr Thr His Ser Arg Leu Arg Ser Ser Leu 
    530                 535                 540                 


Val Phe Lys Pro Thr Leu Pro Glu Gln Lys Glu Val Asn Ser Cys Thr 
545                 550                 555                 560 


Thr Gly Ser Ser Asn Ser Thr Ile Ile Gly Ser Gln Gly Ser Glu Thr 
                565                 570                 575     


Pro Lys Glu Val Pro Asp Thr Pro Thr Asn Val Gln His Leu Thr Asp 
            580                 585                 590         


Lys Pro Leu Pro Glu Ser Ile Pro Lys Leu Pro Leu Gln Ser Glu Ala 
        595                 600                 605             


Pro Lys Met His Thr Leu Gln Val Pro Glu Asn His Ser Val Ala Leu 
    610                 615                 620                 


Asn Gln Thr Thr Asn Gly His Thr Glu Ser Asn Asn Tyr Ile Tyr Lys 
625                 630                 635                 640 


Thr Leu Gly Val Asn Lys Gln Thr Glu Asn Leu Lys Asn Gln Gln Thr 
                645                 650                 655     


Glu Asn Leu Leu Lys Arg Arg Ser Phe Pro Leu Phe Asp Asn Ser Lys 
            660                 665                 670         


Ala Asn Leu Asp Pro Gly Asn Ser Lys His Tyr Val Tyr Ser Thr Leu 
        675                 680                 685             


Thr Arg Asn Arg Val Arg Gln Pro Glu Lys Pro Lys Glu Asp Leu Leu 
    690                 695                 700                 


Lys Ser Ser Lys Ser Met His Asn Val Thr His Asn Leu Glu Glu Asp 
705                 710                 715                 720 


Glu Glu Glu Val Thr Lys Arg Asn Ser Pro Ser Gly Thr Thr Thr Lys 
                725                 730                 735     


Ser Val Ser Ile Ala Ala Leu Leu Asp Val Asn Lys Glu Glu Ser Asn 
            740                 745                 750         


Lys Glu Leu Ala Ser Lys Lys Glu Val Lys Gly Ser Pro Ser Phe Leu 
        755                 760                 765             


Lys Lys Gly Ser Gln Lys Leu Arg Ser Leu Leu Ser Leu Thr Pro Asp 
    770                 775                 780                 


Lys Lys Glu Asn Leu Ser Lys Asn Lys Ala Pro Ala Phe Tyr Arg Leu 
785                 790                 795                 800 


Cys Ser Ser Ser Asp Thr Leu Val Ser Glu Gly Glu Glu Asn Gln Lys 
                805                 810                 815     


Pro Lys Lys Ser Asp Thr Lys Val Asp Ser Ser Pro Arg Arg Lys His 
            820                 825                 830         


Ser Ser Ser Ser Asn Ser Gln Gly Ser Ile His Lys Ser Lys Glu Asp 
        835                 840                 845             


Val Thr Val Ser Pro Ser Gln Glu Ile Asn Ala Pro Pro Asp Glu Asn 
    850                 855                 860                 


Lys Arg Thr Pro Ser Pro Gly Pro Val Glu Ser Lys Phe Leu Glu Arg 
865                 870                 875                 880 


Ala Gly Asp Ala Ser Ala Pro Arg Phe Asn Thr Glu Gln Ile Gln Tyr 
                885                 890                 895     


Arg Asp Ser Arg Glu Ile Asn Ala Val Val Thr Pro Glu Arg Arg Pro 
            900                 905                 910         


Thr Ser Ser Pro Arg Pro Thr Ser Ser Glu Leu Leu Arg Ser His Ser 
        915                 920                 925             


Thr Asp Arg Arg Val Tyr Ser Arg Phe Glu Pro Phe Cys Lys Ile Glu 
    930                 935                 940                 


Ser Ser Ile Gln Pro Thr Ser Asn Met Pro Asn Thr Ser Ile Asn Arg 
945                 950                 955                 960 


Pro Glu Ile Lys Ser Ala Thr Met Gly Asn Ser Tyr Gly Arg Ser Ser 
                965                 970                 975     


Pro Leu Leu Asn Tyr Asn Thr Gly Val Tyr Arg Ser Tyr Gln Pro Asn 
            980                 985                 990         


Glu Asn Lys Phe Arg Gly Phe Met  Gln Lys Phe Gly Asn  Phe Ile His 
        995                 1000                 1005             


Lys Asn  Lys 
    1010     


<210>  3873
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM83D__Homo_sapiens__NP_112181

<400>  3873

Met Ala Leu Leu Ser Glu Gly Leu Asp Glu Val Pro Ala Ala Cys Leu 
1               5                   10                  15      


Ser Pro Cys Gly Pro Pro Asn Pro Thr Glu Leu Phe Ser Glu Ser Arg 
            20                  25                  30          


Arg Leu Ala Leu Glu Glu Leu Val Ala Gly Gly Pro Glu Ala Phe Ala 
        35                  40                  45              


Ala Phe Leu Arg Arg Glu Arg Leu Ala Arg Phe Leu Asn Pro Asp Glu 
    50                  55                  60                  


Val His Ala Ile Leu Arg Ala Ala Glu Arg Pro Gly Glu Glu Gly Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Glu Asp Ser Phe Gly Ser Ser His Asp Cys 
                85                  90                  95      


Ser Ser Gly Thr Tyr Phe Pro Glu Gln Ser Asp Leu Glu Pro Pro Leu 
            100                 105                 110         


Leu Glu Leu Gly Trp Pro Ala Phe Tyr Gln Gly Ala Tyr Arg Gly Ala 
        115                 120                 125             


Thr Arg Val Glu Thr His Phe Gln Pro Arg Gly Ala Gly Glu Gly Gly 
    130                 135                 140                 


Pro Tyr Gly Cys Lys Asp Ala Leu Arg Gln Gln Leu Arg Ser Ala Arg 
145                 150                 155                 160 


Glu Val Ile Ala Val Val Met Asp Val Phe Thr Asp Ile Asp Ile Phe 
                165                 170                 175     


Arg Asp Leu Gln Glu Ile Cys Arg Lys Gln Gly Val Ala Val Tyr Ile 
            180                 185                 190         


Leu Leu Asp Gln Ala Leu Leu Ser Gln Phe Leu Asp Met Cys Met Asp 
        195                 200                 205             


Leu Lys Val His Pro Glu Gln Glu Lys Leu Met Thr Val Arg Thr Ile 
    210                 215                 220                 


Thr Gly Asn Ile Tyr Tyr Ala Arg Ser Gly Thr Lys Ile Ile Gly Lys 
225                 230                 235                 240 


Val His Glu Lys Phe Thr Leu Ile Asp Gly Ile Arg Val Ala Thr Gly 
                245                 250                 255     


Ser Tyr Ser Phe Thr Trp Thr Asp Gly Lys Leu Asn Ser Ser Asn Leu 
            260                 265                 270         


Val Ile Leu Ser Gly Gln Val Val Glu His Phe Asp Leu Glu Phe Arg 
        275                 280                 285             


Ile Leu Tyr Ala Gln Ser Lys Pro Ile Ser Pro Lys Leu Leu Ser His 
    290                 295                 300                 


Phe Gln Ser Ser Asn Lys Phe Asp His Leu Thr Asn Arg Lys Pro Gln 
305                 310                 315                 320 


Ser Lys Glu Leu Thr Leu Gly Asn Leu Leu Arg Met Arg Leu Ala Arg 
                325                 330                 335     


Leu Ser Ser Thr Pro Arg Lys Ala Asp Leu Asp Pro Glu Met Pro Ala 
            340                 345                 350         


Glu Gly Lys Ala Glu Arg Lys Pro His Asp Cys Glu Ser Ser Thr Val 
        355                 360                 365             


Ser Glu Glu Asp Tyr Phe Ser Ser His Arg Asp Glu Leu Gln Ser Arg 
    370                 375                 380                 


Lys Ala Ile Asp Ala Ala Thr Gln Thr Glu Pro Gly Glu Glu Met Pro 
385                 390                 395                 400 


Gly Leu Ser Val Ser Glu Val Gly Thr Gln Thr Ser Ile Thr Thr Ala 
                405                 410                 415     


Cys Ala Gly Thr Gln Thr Ala Val Ile Thr Arg Ile Ala Ser Ser Gln 
            420                 425                 430         


Thr Thr Ile Trp Ser Arg Ser Thr Thr Thr Gln Thr Asp Met Asp Glu 
        435                 440                 445             


Asn Ile Leu Phe Pro Arg Gly Thr Gln Ser Thr Glu Gly Ser Pro Val 
    450                 455                 460                 


Ser Lys Met Ser Val Ser Arg Ser Ser Ser Leu Lys Ser Ser Ser Ser 
465                 470                 475                 480 


Val Ser Ser Gln Gly Ser Val Ala Ser Ser Thr Gly Ser Pro Ala Ser 
                485                 490                 495     


Ile Arg Thr Thr Asp Phe His Asn Pro Gly Tyr Pro Lys Tyr Leu Gly 
            500                 505                 510         


Thr Pro His Leu Glu Leu Tyr Leu Ser Asp Ser Leu Arg Asn Leu Asn 
        515                 520                 525             


Lys Glu Arg Gln Phe His Phe Ala Gly Ile Arg Ser Arg Leu Asn His 
    530                 535                 540                 


Met Leu Ala Met Leu Ser Arg Arg Thr Leu Phe Thr Glu Asn His Leu 
545                 550                 555                 560 


Gly Leu His Ser Gly Asn Phe Ser Arg Val Asn Leu Leu Ala Val Arg 
                565                 570                 575     


Asp Val Ala Leu Tyr Pro Ser Tyr Gln 
            580                 585 


<210>  3874
<211>  1185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM83H__Homo_sapiens__XP_006725151

<400>  3874

Met Ala Pro Gly Pro Asn Met Ala Arg Arg Ser Gln Ser Ser Ser Gln 
1               5                   10                  15      


Gly Asp Asn Pro Leu Ala Pro Gly Tyr Leu Pro Pro His Tyr Lys Glu 
            20                  25                  30          


Tyr Tyr Arg Leu Ala Val Asp Ala Leu Ala Glu Gly Gly Ser Glu Ala 
        35                  40                  45              


Tyr Ser Arg Phe Leu Ala Thr Glu Gly Ala Pro Asp Phe Leu Cys Pro 
    50                  55                  60                  


Glu Glu Leu Glu His Val Ser Arg His Leu Arg Pro Pro Gln Tyr Val 
65                  70                  75                  80  


Thr Arg Glu Pro Pro Glu Gly Ser Leu Leu Asp Val Asp Met Asp Gly 
                85                  90                  95      


Ser Ser Gly Thr Tyr Trp Pro Val Asn Ser Asp Gln Ala Val Pro Glu 
            100                 105                 110         


Leu Asp Leu Gly Trp Pro Leu Thr Phe Gly Phe Gln Gly Thr Glu Val 
        115                 120                 125             


Thr Thr Leu Val Gln Pro Pro Pro Pro Asp Ser Pro Ser Ile Lys Asp 
    130                 135                 140                 


Glu Ala Arg Arg Met Ile Arg Ser Ala Gln Gln Val Val Ala Val Val 
145                 150                 155                 160 


Met Asp Met Phe Thr Asp Val Asp Leu Leu Ser Glu Val Leu Glu Ala 
                165                 170                 175     


Ala Ala Arg Arg Val Pro Val Tyr Ile Leu Leu Asp Glu Met Asn Ala 
            180                 185                 190         


Gln His Phe Leu Asp Met Ala Asp Lys Cys Arg Val Asn Leu Gln His 
        195                 200                 205             


Val Asp Phe Leu Arg Val Arg Thr Val Ala Gly Pro Thr Tyr Tyr Cys 
    210                 215                 220                 


Arg Thr Gly Lys Ser Phe Lys Gly His Val Lys Glu Lys Phe Leu Leu 
225                 230                 235                 240 


Val Asp Cys Ala Val Val Met Ser Gly Ser Tyr Ser Phe Met Trp Ser 
                245                 250                 255     


Phe Glu Lys Ile His Arg Ser Leu Ala His Val Phe Gln Gly Glu Leu 
            260                 265                 270         


Val Ser Ser Phe Asp Glu Glu Phe Arg Ile Leu Phe Ala Gln Ser Glu 
        275                 280                 285             


Pro Leu Val Pro Ser Ala Ala Ala Leu Ala Arg Met Asp Ala Tyr Ala 
    290                 295                 300                 


Leu Ala Pro Tyr Ala Gly Ala Gly Pro Leu Val Gly Val Pro Gly Val 
305                 310                 315                 320 


Gly Ala Pro Thr Pro Phe Ser Phe Pro Lys Arg Ala His Leu Leu Phe 
                325                 330                 335     


Pro Pro Pro Arg Glu Glu Gly Leu Gly Phe Pro Ser Phe Leu Asp Pro 
            340                 345                 350         


Asp Arg His Phe Leu Ser Ala Phe Arg Arg Glu Glu Pro Pro Arg Met 
        355                 360                 365             


Pro Gly Gly Ala Leu Glu Pro His Ala Gly Leu Arg Pro Leu Ser Arg 
    370                 375                 380                 


Arg Leu Glu Ala Glu Ala Gly Pro Ala Gly Glu Leu Ala Gly Ala Arg 
385                 390                 395                 400 


Gly Phe Phe Gln Ala Arg His Leu Glu Met Asp Ala Phe Lys Arg His 
                405                 410                 415     


Ser Phe Ala Thr Glu Gly Ala Gly Ala Val Glu Asn Phe Ala Ala Ala 
            420                 425                 430         


Arg Gln Val Ser Arg Gln Thr Phe Leu Ser His Gly Asp Asp Phe Arg 
        435                 440                 445             


Phe Gln Thr Ser His Phe His Arg Asp Gln Leu Tyr Gln Gln Gln Tyr 
    450                 455                 460                 


Gln Trp Asp Pro Gln Leu Thr Pro Ala Arg Pro Gln Gly Leu Phe Glu 
465                 470                 475                 480 


Lys Leu Arg Gly Gly Arg Ala Gly Phe Ala Asp Pro Asp Asp Phe Thr 
                485                 490                 495     


Leu Gly Ala Gly Pro Arg Phe Pro Glu Leu Gly Pro Asp Gly His Gln 
            500                 505                 510         


Arg Leu Asp Tyr Val Pro Ser Ser Ala Ser Arg Glu Val Arg His Gly 
        515                 520                 525             


Ser Asp Pro Ala Phe Ala Pro Gly Pro Arg Gly Leu Glu Pro Ser Gly 
    530                 535                 540                 


Ala Pro Arg Pro Asn Leu Thr Gln Arg Phe Pro Cys Gln Ala Ala Ala 
545                 550                 555                 560 


Arg Pro Gly Pro Asp Pro Ala Pro Glu Ala Glu Pro Glu Arg Arg Gly 
                565                 570                 575     


Gly Pro Glu Gly Arg Ala Gly Leu Arg Arg Trp Arg Leu Ala Ser Tyr 
            580                 585                 590         


Leu Ser Gly Cys His Gly Glu Asp Gly Gly Asp Asp Gly Leu Pro Ala 
        595                 600                 605             


Pro Met Glu Ala Glu Ala Tyr Glu Asp Asp Val Leu Ala Pro Gly Gly 
    610                 615                 620                 


Arg Ala Pro Ala Gly Asp Leu Leu Pro Ser Ala Phe Arg Val Pro Ala 
625                 630                 635                 640 


Ala Phe Pro Thr Lys Val Pro Val Pro Gly Pro Gly Ser Gly Gly Asn 
                645                 650                 655     


Gly Pro Glu Arg Glu Gly Pro Glu Glu Pro Gly Leu Ala Lys Gln Asp 
            660                 665                 670         


Ser Phe Arg Ser Arg Leu Asn Pro Leu Val Gln Arg Ser Ser Arg Leu 
        675                 680                 685             


Arg Ser Ser Leu Ile Phe Ser Thr Ser Gln Ala Glu Gly Ala Ala Gly 
    690                 695                 700                 


Ala Ala Ala Ala Thr Glu Lys Val Gln Leu Leu His Lys Glu Gln Thr 
705                 710                 715                 720 


Val Ser Glu Thr Leu Gly Pro Gly Gly Glu Ala Val Arg Ser Ala Ala 
                725                 730                 735     


Ser Thr Lys Val Ala Glu Leu Leu Glu Lys Tyr Lys Gly Pro Ala Arg 
            740                 745                 750         


Asp Pro Gly Gly Gly Ala Gly Ala Ile Thr Val Ala Ser His Ser Lys 
        755                 760                 765             


Ala Val Val Ser Gln Ala Trp Arg Glu Glu Val Ala Ala Pro Gly Ala 
    770                 775                 780                 


Val Gly Gly Glu Arg Arg Ser Leu Glu Ser Cys Leu Leu Asp Leu Arg 
785                 790                 795                 800 


Asp Ser Phe Ala Gln Gln Leu His Gln Glu Ala Glu Arg Gln Pro Gly 
                805                 810                 815     


Ala Ala Ser Leu Thr Ala Ala Gln Leu Leu Asp Thr Leu Gly Arg Ser 
            820                 825                 830         


Gly Ser Asp Arg Leu Pro Ser Arg Phe Leu Ser Ala Gln Ser His Ser 
        835                 840                 845             


Thr Ser Pro Gln Gly Leu Asp Ser Pro Leu Pro Leu Glu Gly Ser Gly 
    850                 855                 860                 


Ala His Gln Val Leu His Asn Glu Ser Lys Gly Ser Pro Thr Ser Ala 
865                 870                 875                 880 


Tyr Pro Glu Arg Lys Gly Ser Pro Thr Pro Gly Phe Ser Thr Arg Arg 
                885                 890                 895     


Gly Ser Pro Thr Thr Gly Phe Ile Glu Gln Lys Gly Ser Pro Thr Ser 
            900                 905                 910         


Ala Tyr Pro Glu Arg Arg Gly Ser Pro Val Pro Pro Val Pro Glu Arg 
        915                 920                 925             


Arg Ser Ser Pro Val Pro Pro Val Pro Glu Arg Arg Gly Ser Leu Thr 
    930                 935                 940                 


Leu Thr Ile Ser Gly Glu Ser Pro Lys Ala Gly Pro Ala Glu Glu Gly 
945                 950                 955                 960 


Pro Ser Gly Pro Met Glu Val Leu Arg Lys Gly Ser Leu Arg Leu Arg 
                965                 970                 975     


Gln Leu Leu Ser Pro Lys Gly Glu Arg Arg Met Glu Asp Glu Gly Gly 
            980                 985                 990         


Phe Pro Val Pro Gln Glu Asn Gly  Gln Pro Glu Ser Pro  Arg Arg Leu 
        995                 1000                 1005             


Ser Leu  Gly Gln Gly Asp Ser  Thr Glu Ala Ala Thr  Glu Glu Arg 
    1010                 1015                 1020             


Gly Pro  Arg Ala Arg Leu Ser  Ser Ala Thr Ala Asn  Ala Leu Tyr 
    1025                 1030                 1035             


Ser Ser  Asn Leu Arg Asp Asp  Thr Lys Ala Ile Leu  Glu Gln Ile 
    1040                 1045                 1050             


Ser Ala  His Gly Gln Lys His  Arg Ala Val Pro Ala  Pro Ser Pro 
    1055                 1060                 1065             


Gly Pro  Thr His Asn Ser Pro  Glu Leu Gly Arg Pro  Pro Ala Ala 
    1070                 1075                 1080             


Gly Val  Leu Ala Pro Asp Met  Ser Asp Lys Asp Lys  Cys Ser Ala 
    1085                 1090                 1095             


Ile Phe  Arg Ser Asp Ser Leu  Gly Thr Gln Gly Arg  Leu Ser Arg 
    1100                 1105                 1110             


Thr Leu  Pro Ala Ser Ala Glu  Glu Arg Asp Arg Leu  Leu Arg Arg 
    1115                 1120                 1125             


Met Glu  Ser Met Arg Lys Glu  Lys Arg Val Tyr Ser  Arg Phe Glu 
    1130                 1135                 1140             


Val Phe  Cys Lys Lys Glu Glu  Ala Ser Ser Pro Gly  Ala Gly Glu 
    1145                 1150                 1155             


Gly Pro  Ala Glu Glu Gly Thr  Arg Asp Ser Lys Val  Gly Lys Phe 
    1160                 1165                 1170             


Val Pro  Lys Ile Leu Gly Thr  Phe Lys Ser Lys Lys  
    1175                 1180                 1185 


<210>  3875
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM84A__Homo_sapiens__NP_660158

<400>  3875

Met Gly Asn Gln Leu Asp Arg Ile Thr His Leu Asn Tyr Ser Glu Leu 
1               5                   10                  15      


Pro Thr Gly Asp Pro Ser Gly Ile Glu Lys Asp Glu Leu Arg Val Gly 
            20                  25                  30          


Val Ala Tyr Phe Phe Ser Asp Asp Glu Glu Asp Leu Asp Glu Arg Gly 
        35                  40                  45              


Gln Pro Asp Lys Phe Gly Val Lys Ala Pro Pro Gly Cys Thr Pro Cys 
    50                  55                  60                  


Pro Glu Ser Pro Ser Arg His His His His Leu Leu His Gln Leu Val 
65                  70                  75                  80  


Leu Asn Glu Thr Gln Phe Ser Ala Phe Arg Gly Gln Glu Cys Ile Phe 
                85                  90                  95      


Ser Lys Val Ser Gly Gly Pro Gln Gly Ala Asp Leu Ser Val Tyr Ala 
            100                 105                 110         


Val Thr Ala Leu Pro Ala Leu Cys Glu Pro Gly Asp Leu Leu Glu Leu 
        115                 120                 125             


Leu Trp Leu Gln Pro Ala Pro Glu Pro Pro Ala Pro Ala Pro His Trp 
    130                 135                 140                 


Ala Val Tyr Val Gly Gly Gly Gln Ile Ile His Leu His Gln Gly Glu 
145                 150                 155                 160 


Ile Arg Gln Asp Ser Leu Tyr Glu Ala Gly Ala Ala Asn Val Gly Arg 
                165                 170                 175     


Val Val Asn Ser Trp Tyr Arg Tyr Arg Pro Leu Val Ala Glu Leu Val 
            180                 185                 190         


Val Gln Asn Ala Cys Gly His Leu Gly Leu Lys Ser Glu Glu Ile Cys 
        195                 200                 205             


Trp Thr Asn Ser Glu Ser Phe Ala Ala Trp Cys Arg Phe Gly Lys Arg 
    210                 215                 220                 


Glu Phe Lys Ala Gly Gly Glu Val Pro Ala Gly Thr Gln Pro Pro Gln 
225                 230                 235                 240 


Gln Gln Tyr Tyr Leu Lys Val His Leu Gly Glu Asn Lys Val His Thr 
                245                 250                 255     


Ala Arg Phe His Ser Leu Glu Asp Leu Ile Arg Glu Lys Arg Arg Ile 
            260                 265                 270         


Asp Ala Ser Gly Arg Leu Arg Val Leu Gln Glu Leu Ala Asp Leu Val 
        275                 280                 285             


Asp Asp Lys Glu 
    290         


<210>  3876
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM84B__Homo_sapiens__NP_777571

<400>  3876

Met Gly Asn Gln Val Glu Lys Leu Thr His Leu Ser Tyr Lys Glu Val 
1               5                   10                  15      


Pro Thr Ala Asp Pro Thr Gly Val Asp Arg Asp Asp Gly Pro Arg Ile 
            20                  25                  30          


Gly Val Ser Tyr Ile Phe Ser Asn Asp Asp Glu Asp Val Glu Pro Gln 
        35                  40                  45              


Pro Pro Pro Gln Gly Pro Asp Gly Gly Gly Leu Pro Asp Gly Gly Asp 
    50                  55                  60                  


Gly Pro Pro Pro Pro Gln Pro Gln Pro Tyr Asp Pro Arg Leu His Glu 
65                  70                  75                  80  


Val Glu Cys Ser Val Phe Tyr Arg Asp Glu Cys Ile Tyr Gln Lys Ser 
                85                  90                  95      


Phe Ala Pro Gly Ser Ala Ala Leu Ser Thr Tyr Thr Pro Glu Asn Leu 
            100                 105                 110         


Leu Asn Lys Cys Lys Pro Gly Asp Leu Val Glu Phe Val Ser Gln Ala 
        115                 120                 125             


Gln Tyr Pro His Trp Ala Val Tyr Val Gly Asn Phe Gln Val Val His 
    130                 135                 140                 


Leu His Arg Leu Glu Val Ile Asn Ser Phe Leu Thr Asp Ala Ser Gln 
145                 150                 155                 160 


Gly Arg Arg Gly Arg Val Val Asn Asp Leu Tyr Arg Tyr Lys Pro Leu 
                165                 170                 175     


Ser Ser Ser Ala Val Val Arg Asn Ala Leu Ala His Val Gly Ala Lys 
            180                 185                 190         


Glu Arg Glu Leu Ser Trp Arg Asn Ser Glu Ser Phe Ala Ala Trp Cys 
        195                 200                 205             


Arg Tyr Gly Lys Arg Glu Phe Lys Ile Gly Gly Glu Leu Arg Ile Gly 
    210                 215                 220                 


Lys Gln Pro Tyr Arg Leu Gln Ile Gln Leu Ser Ala Gln Arg Ser His 
225                 230                 235                 240 


Thr Leu Glu Phe Gln Ser Leu Glu Asp Leu Ile Met Glu Lys Arg Arg 
                245                 250                 255     


Asn Asp Gln Ile Gly Arg Ala Ala Val Leu Gln Glu Leu Ala Thr His 
            260                 265                 270         


Leu His Pro Ala Glu Pro Glu Glu Gly Asp Ser Asn Val Ala Arg Thr 
        275                 280                 285             


Thr Pro Pro Pro Gly Arg Pro Pro Ala Pro Ser Ser Glu Glu Glu Asp 
    290                 295                 300                 


Gly Glu Ala Val Ala His 
305                 310 


<210>  3877
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM89A__Homo_sapiens__NP_940954

<400>  3877

Met Ser Gly Ala Arg Ala Ala Pro Gly Ala Ala Gly Asn Gly Ala Val 
1               5                   10                  15      


Arg Gly Leu Arg Val Asp Gly Leu Pro Pro Leu Pro Lys Ser Leu Ser 
            20                  25                  30          


Gly Leu Leu His Ser Ala Ser Gly Gly Gly Ala Ser Gly Gly Trp Arg 
        35                  40                  45              


His Leu Glu Arg Leu Tyr Ala Gln Lys Ser Arg Ile Gln Asp Glu Leu 
    50                  55                  60                  


Ser Arg Gly Gly Pro Gly Gly Gly Gly Ala Arg Ala Ala Ala Leu Pro 
65                  70                  75                  80  


Ala Lys Pro Pro Asn Leu Asp Ala Ala Leu Ala Leu Leu Arg Lys Glu 
                85                  90                  95      


Met Val Gly Leu Arg Gln Leu Asp Met Ser Leu Leu Cys Gln Leu Tyr 
            100                 105                 110         


Ser Leu Tyr Glu Ser Ile Gln Glu Tyr Lys Gly Ala Cys Gln Ala Ala 
        115                 120                 125             


Ser Ser Pro Asp Cys Thr Tyr Ala Leu Glu Asn Gly Phe Phe Asp Glu 
    130                 135                 140                 


Glu Glu Glu Tyr Phe Gln Glu Gln Asn Ser Leu His Asp Arg Arg Asp 
145                 150                 155                 160 


Arg Gly Pro Pro Arg Asp Leu Ser Leu Pro Val Ser Ser Leu Ser Ser 
                165                 170                 175     


Ser Asp Trp Ile Leu Glu Ser Ile 
            180                 


<210>  3878
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM92A1__Homo_sapiens__NP_001269963

<400>  3878

Met Met Arg Arg Thr Leu Glu Asn Arg Asn Ala Gln Thr Lys Gln Leu 
1               5                   10                  15      


Gln Thr Ala Val Ser Asn Val Glu Lys His Phe Gly Glu Leu Cys Gln 
            20                  25                  30          


Ile Phe Ala Ala Tyr Val Arg Lys Thr Ala Arg Leu Arg Asp Lys Ala 
        35                  40                  45              


Asp Leu Leu Val Asn Glu Ile Asn Ala Tyr Ala Ala Thr Glu Thr Pro 
    50                  55                  60                  


His Leu Lys Leu Gly Leu Met Asn Phe Ala Asp Glu Phe Ala Lys Leu 
65                  70                  75                  80  


Gln Asp Tyr Arg Gln Ala Glu Val Glu Arg Leu Glu Ala Lys Val Val 
                85                  90                  95      


Glu Pro Leu Lys Thr Tyr Gly Thr Ile Val Lys Met Lys Arg Asp Asp 
            100                 105                 110         


Leu Lys Ala Thr Leu Thr Ala Arg Asn Arg Glu Ala Lys Gln Leu Thr 
        115                 120                 125             


Gln Leu Glu Arg Thr Arg Gln Arg Asn Pro Ser Asp Arg His Val Ile 
    130                 135                 140                 


Ser Gln Ala Glu Thr Glu Leu Gln Arg Ala Ala Met Asp Ala Ser Arg 
145                 150                 155                 160 


Thr Ser Arg His Leu Glu Glu Thr Ile Asn Asn Phe Glu Arg Gln Lys 
                165                 170                 175     


Met Lys Asp Ile Lys Val Phe Arg Asn Ser Leu Tyr Ala Pro Asp Tyr 
            180                 185                 190         


Ser Ser Arg Leu Asp Ile Val Arg Ala Asn Ser Lys Ser Pro Leu Gln 
        195                 200                 205             


Arg Ser Leu Ser Ala Lys Cys Val Ser Gly Thr Gly Gln Val Ser Thr 
    210                 215                 220                 


Cys Arg Leu Arg Lys Asp Gln Gln Ala Glu Asp Asp Glu Asp Asp Glu 
225                 230                 235                 240 


Leu Asp Val Thr Glu Glu Glu Asn Phe Leu Lys 
                245                 250     


<210>  3879
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM92B__Homo_sapiens__NP_940893

<400>  3879

Met Asn Ile Val Phe Ser Arg Asp Ser Gln Val Arg Val Met Glu Asn 
1               5                   10                  15      


Thr Val Ala Asn Thr Glu Lys Tyr Phe Gly Gln Phe Cys Ser Leu Leu 
            20                  25                  30          


Ala Ala Tyr Thr Arg Lys Thr Ala Arg Leu Arg Asp Lys Ala Asp Gln 
        35                  40                  45              


Leu Val Lys Gln Leu Ile Asp Phe Ala Asn Ser Glu Asn Pro Glu Leu 
    50                  55                  60                  


Arg Ala Thr Met Arg Gly Phe Ala Glu Asp Leu Ala Lys Val Gln Asp 
65                  70                  75                  80  


Tyr Arg Gln Ala Gln Val Glu Arg Leu Glu Thr Lys Val Val Asn Pro 
                85                  90                  95      


Leu Lys Leu Tyr Gly Ala Gln Ile Lys Gln Thr Arg Ala Glu Ile Lys 
            100                 105                 110         


Lys Phe Lys His Val Gln Asn His Glu Ile Lys Gln Leu Glu Lys Leu 
        115                 120                 125             


Glu Lys Leu Arg Gln Lys Ser Pro Ser Asp Gln Gln Met Ile Ser Gln 
    130                 135                 140                 


Ala Glu Thr Arg Val Gln Arg Ala Ala Val Asp Ser Ser Arg Thr Thr 
145                 150                 155                 160 


Leu Gln Leu Glu Glu Thr Val Asp Gly Phe Gln Arg Gln Lys Leu Lys 
                165                 170                 175     


Asp Leu Gln Lys Phe Phe Cys Asp Phe Val Thr Ile Glu Met Val Phe 
            180                 185                 190         


His Ala Lys Ala Val Glu Val Tyr Ser Ser Ala Phe Gln Thr Leu Glu 
        195                 200                 205             


Lys Tyr Asp Leu Glu Arg Asp Leu Leu Asp Phe Arg Ala Lys Met Gln 
    210                 215                 220                 


Gly Val Tyr Gly His Tyr Asp Thr Arg Leu Leu Ala Asn Thr Ser Pro 
225                 230                 235                 240 


Pro Pro Ser Val Leu Gln Ser Leu Ala Ser Gln Gly Thr Leu Gln Val 
                245                 250                 255     


Gln Leu Ser Arg Ala Asn Glu Asp Pro Glu His Pro His Ala Asn His 
            260                 265                 270         


Gly Arg Phe Ser Leu Cys Glu Trp Val Val Lys Gly Gln Pro Ala His 
        275                 280                 285             


Cys Val Cys Gly Gln Gly Gly His Leu Met Leu Pro Gly His Ser Leu 
    290                 295                 300                 


<210>  3880
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM9B__Homo_sapiens__NP_995321

<400>  3880

Met Ala Ala Trp Gly Lys Lys His Ala Gly Lys Asp Pro Val Arg Asp 
1               5                   10                  15      


Glu Cys Glu Glu Arg Asn Arg Phe Thr Glu Thr Arg Glu Glu Asp Val 
            20                  25                  30          


Thr Asp Glu His Gly Glu Arg Glu Pro Phe Ala Glu Thr Asp Glu His 
        35                  40                  45              


Thr Gly Ala Asn Thr Lys Lys Pro Glu Asp Thr Ala Glu Asp Leu Thr 
    50                  55                  60                  


Ala Lys Arg Lys Arg Met Lys Met Asp Lys Thr Cys Ser Lys Thr Lys 
65                  70                  75                  80  


Asn Lys Ser Lys His Ala Leu Arg Lys Lys Gln Leu Lys Arg Gln Lys 
                85                  90                  95      


Arg Asp Tyr Ile His Ser Leu Lys Leu Leu Asn Val Leu Glu Glu Tyr 
            100                 105                 110         


Ile Thr Asp Glu Gln Lys Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
        115                 120                 125             


Glu Leu Ile Arg Ile Phe Gln Glu Gln Gln Lys Lys Trp Gln Gln Tyr 
    130                 135                 140                 


Arg Ser Val Arg Arg Glu Arg Leu Lys Glu Met Lys Leu Leu Arg Asp 
145                 150                 155                 160 


Gln Phe Val Lys Ala Leu Glu Asp Phe Glu Asp Leu Cys Asp Arg Val 
                165                 170                 175     


Phe Ser Asp Glu Asp Ser Glu Leu Asp Asn 
            180                 185     


<210>  3881
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAN1__Homo_sapiens__NP_001139568

<400>  3881

Met Met Ser Glu Gly Lys Pro Pro Asp Lys Lys Arg Pro Arg Arg Ser 
1               5                   10                  15      


Leu Ser Ile Ser Lys Asn Lys Lys Lys Ala Ser Asn Ser Ile Ile Ser 
            20                  25                  30          


Cys Phe Asn Asn Ala Pro Pro Ala Lys Leu Ala Cys Pro Val Cys Ser 
        35                  40                  45              


Lys Met Val Pro Arg Tyr Asp Leu Asn Arg His Leu Asp Glu Met Cys 
    50                  55                  60                  


Ala Asn Asn Asp Phe Val Gln Val Asp Pro Gly Gln Val Gly Leu Ile 
65                  70                  75                  80  


Asn Ser Asn Val Ser Met Val Asp Leu Thr Ser Val Thr Leu Glu Asp 
                85                  90                  95      


Val Thr Pro Lys Lys Ser Pro Pro Pro Lys Thr Asn Leu Thr Pro Gly 
            100                 105                 110         


Gln Ser Asp Ser Ala Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr 
        115                 120                 125             


Phe Lys Ser Asn Asp Val Val Cys Lys Asn Gln Asp Glu Leu Arg Asn 
    130                 135                 140                 


Arg Ser Val Lys Val Ile Cys Leu Gly Ser Leu Ala Ser Lys Leu Ser 
145                 150                 155                 160 


Arg Lys Tyr Val Lys Ala Lys Lys Ser Ile Asp Lys Asp Glu Glu Phe 
                165                 170                 175     


Ala Gly Ser Ser Pro Gln Ser Ser Lys Ser Thr Val Val Lys Ser Leu 
            180                 185                 190         


Ile Asp Asn Ser Ser Glu Ile Glu Asp Glu Asp Gln Ile Leu Glu Asn 
        195                 200                 205             


Ser Ser Gln Lys Glu Asn Val Phe Lys Cys Asp Ser Leu Lys Glu Glu 
    210                 215                 220                 


Cys Ile Pro Glu His Met Val Arg Gly Ser Lys Ile Met Glu Ala Glu 
225                 230                 235                 240 


Ser Gln Lys Ala Thr Arg Glu Cys Glu Lys Ser Ala Leu Thr Pro Gly 
                245                 250                 255     


Phe Ser Asp Asn Ala Ile Met Leu Phe Ser Pro Asp Phe Thr Leu Arg 
            260                 265                 270         


Asn Thr Leu Lys Ser Thr Ser Glu Asp Ser Leu Val Lys Gln Glu Cys 
        275                 280                 285             


Ile Lys Glu Val Val Glu Lys Arg Glu Ala Cys His Cys Glu Glu Val 
    290                 295                 300                 


Lys Met Thr Val Ala Ser Glu Ala Lys Ile Gln Leu Ser Asp Ser Glu 
305                 310                 315                 320 


Ala Lys Ser His Ser Ser Ala Asp Asp Ala Ser Ala Trp Ser Asn Ile 
                325                 330                 335     


Gln Glu Ala Pro Leu Gln Asp Asp Ser Cys Leu Asn Asn Asp Ile Pro 
            340                 345                 350         


His Ser Ile Pro Leu Glu Gln Gly Ser Ser Cys Asn Gly Pro Gly Gln 
        355                 360                 365             


Thr Thr Gly His Pro Tyr Tyr Leu Arg Ser Phe Leu Val Val Leu Lys 
    370                 375                 380                 


Thr Val Leu Glu Asn Glu Asp Asp Met Leu Leu Phe Asp Glu Gln Glu 
385                 390                 395                 400 


Lys Gly Ile Val Thr Lys Phe Tyr Gln Leu Ser Ala Thr Gly Gln Lys 
                405                 410                 415     


Leu Tyr Val Arg Leu Phe Gln Arg Lys Leu Ser Trp Ile Lys Met Thr 
            420                 425                 430         


Lys Leu Glu Tyr Glu Glu Ile Ala Leu Asp Leu Thr Pro Val Ile Glu 
        435                 440                 445             


Glu Leu Thr Asn Ala Gly Phe Leu Gln Thr Glu Ser Glu Leu Gln Glu 
    450                 455                 460                 


Leu Ser Glu Val Leu Glu Leu Leu Ser Ala Pro Glu Leu Lys Ser Leu 
465                 470                 475                 480 


Ala Lys Thr Phe His Leu Val Asn Pro Asn Gly Gln Lys Gln Gln Leu 
                485                 490                 495     


Val Asp Ala Phe Leu Lys Leu Ala Lys Gln Arg Ser Val Cys Thr Trp 
            500                 505                 510         


Gly Lys Asn Lys Pro Gly Ile Gly Ala Val Ile Leu Lys Arg Phe Cys 
        515                 520                 525             


Trp Leu Leu Leu Gln 
    530             


<210>  3882
<211>  1455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCA__Homo_sapiens__NP_000126

<400>  3882

Met Ser Asp Ser Trp Val Pro Asn Ser Ala Ser Gly Gln Asp Pro Gly 
1               5                   10                  15      


Gly Arg Arg Arg Ala Trp Ala Glu Leu Leu Ala Gly Arg Val Lys Arg 
            20                  25                  30          


Glu Lys Tyr Asn Pro Glu Arg Ala Gln Lys Leu Lys Glu Ser Ala Val 
        35                  40                  45              


Arg Leu Leu Arg Ser His Gln Asp Leu Asn Ala Leu Leu Leu Glu Val 
    50                  55                  60                  


Glu Gly Pro Leu Cys Lys Lys Leu Ser Leu Ser Lys Val Ile Asp Cys 
65                  70                  75                  80  


Asp Ser Ser Glu Ala Tyr Ala Asn His Ser Ser Ser Phe Ile Gly Ser 
                85                  90                  95      


Ala Leu Gln Asp Gln Ala Ser Arg Leu Gly Val Pro Val Gly Ile Leu 
            100                 105                 110         


Ser Ala Gly Met Val Ala Ser Ser Val Gly Gln Ile Cys Thr Ala Pro 
        115                 120                 125             


Ala Glu Thr Ser His Pro Val Leu Leu Thr Val Glu Gln Arg Lys Lys 
    130                 135                 140                 


Leu Ser Ser Leu Leu Glu Phe Ala Gln Tyr Leu Leu Ala His Ser Met 
145                 150                 155                 160 


Phe Ser Arg Leu Ser Phe Cys Gln Glu Leu Trp Lys Ile Gln Ser Ser 
                165                 170                 175     


Leu Leu Leu Glu Ala Val Trp His Leu His Val Gln Gly Ile Val Ser 
            180                 185                 190         


Leu Gln Glu Leu Leu Glu Ser His Pro Asp Met His Ala Val Gly Ser 
        195                 200                 205             


Trp Leu Phe Arg Asn Leu Cys Cys Leu Cys Glu Gln Met Glu Ala Ser 
    210                 215                 220                 


Cys Gln His Ala Asp Val Ala Arg Ala Met Leu Ser Asp Phe Val Gln 
225                 230                 235                 240 


Met Phe Val Leu Arg Gly Phe Gln Lys Asn Ser Asp Leu Arg Arg Thr 
                245                 250                 255     


Val Glu Pro Glu Lys Met Pro Gln Val Thr Val Asp Val Leu Gln Arg 
            260                 265                 270         


Met Leu Ile Phe Ala Leu Asp Ala Leu Ala Ala Gly Val Gln Glu Glu 
        275                 280                 285             


Ser Ser Thr His Lys Ile Val Arg Cys Trp Phe Gly Val Phe Ser Gly 
    290                 295                 300                 


His Thr Leu Gly Ser Val Ile Ser Thr Asp Pro Leu Lys Arg Phe Phe 
305                 310                 315                 320 


Ser His Thr Leu Thr Gln Ile Leu Thr His Ser Pro Val Leu Lys Ala 
                325                 330                 335     


Ser Asp Ala Val Gln Met Gln Arg Glu Trp Ser Phe Ala Arg Thr His 
            340                 345                 350         


Pro Leu Leu Thr Ser Leu Tyr Arg Arg Leu Phe Val Met Leu Ser Ala 
        355                 360                 365             


Glu Glu Leu Val Gly His Leu Gln Glu Val Leu Glu Thr Gln Glu Val 
    370                 375                 380                 


His Trp Gln Arg Val Leu Ser Phe Val Ser Ala Leu Val Val Cys Phe 
385                 390                 395                 400 


Pro Glu Ala Gln Gln Leu Leu Glu Asp Trp Val Ala Arg Leu Met Ala 
                405                 410                 415     


Gln Ala Phe Glu Ser Cys Gln Leu Asp Ser Met Val Thr Ala Phe Leu 
            420                 425                 430         


Val Val Arg Gln Ala Ala Leu Glu Gly Pro Ser Ala Phe Leu Ser Tyr 
        435                 440                 445             


Ala Asp Trp Phe Lys Ala Ser Phe Gly Ser Thr Arg Gly Tyr His Gly 
    450                 455                 460                 


Cys Ser Lys Lys Ala Leu Val Phe Leu Phe Thr Phe Leu Ser Glu Leu 
465                 470                 475                 480 


Val Pro Phe Glu Ser Pro Arg Tyr Leu Gln Val His Ile Leu His Pro 
                485                 490                 495     


Pro Leu Val Pro Gly Lys Tyr Arg Ser Leu Leu Thr Asp Tyr Ile Ser 
            500                 505                 510         


Leu Ala Lys Thr Arg Leu Ala Asp Leu Lys Val Ser Ile Glu Asn Met 
        515                 520                 525             


Gly Leu Tyr Glu Asp Leu Ser Ser Ala Gly Asp Ile Thr Glu Pro His 
    530                 535                 540                 


Ser Gln Ala Leu Gln Asp Val Glu Lys Ala Ile Met Val Phe Glu His 
545                 550                 555                 560 


Thr Gly Asn Ile Pro Val Thr Val Met Glu Ala Ser Ile Phe Arg Arg 
                565                 570                 575     


Pro Tyr Tyr Val Ser His Phe Leu Pro Ala Leu Leu Thr Pro Arg Val 
            580                 585                 590         


Leu Pro Lys Val Pro Asp Ser Arg Val Ala Phe Ile Glu Ser Leu Lys 
        595                 600                 605             


Arg Ala Asp Lys Ile Pro Pro Ser Leu Tyr Ser Thr Tyr Cys Gln Ala 
    610                 615                 620                 


Cys Ser Ala Ala Glu Glu Lys Pro Glu Asp Ala Ala Leu Gly Val Arg 
625                 630                 635                 640 


Ala Glu Pro Asn Ser Ala Glu Glu Pro Leu Gly Gln Leu Thr Ala Ala 
                645                 650                 655     


Leu Gly Glu Leu Arg Ala Ser Met Thr Asp Pro Ser Gln Arg Asp Val 
            660                 665                 670         


Ile Ser Ala Gln Val Ala Val Ile Ser Glu Arg Leu Arg Ala Val Leu 
        675                 680                 685             


Gly His Asn Glu Asp Asp Ser Ser Val Glu Ile Ser Lys Ile Gln Leu 
    690                 695                 700                 


Ser Ile Asn Thr Pro Arg Leu Glu Pro Arg Glu His Met Ala Val Asp 
705                 710                 715                 720 


Leu Leu Leu Thr Ser Phe Cys Gln Asn Leu Met Ala Ala Ser Ser Val 
                725                 730                 735     


Ala Pro Pro Glu Arg Gln Gly Pro Trp Ala Ala Leu Phe Val Arg Thr 
            740                 745                 750         


Met Cys Gly Arg Val Leu Pro Ala Val Leu Thr Arg Leu Cys Gln Leu 
        755                 760                 765             


Leu Arg His Gln Gly Pro Ser Leu Ser Ala Pro His Val Leu Gly Leu 
    770                 775                 780                 


Ala Ala Leu Ala Val His Leu Gly Glu Ser Arg Ser Ala Leu Pro Glu 
785                 790                 795                 800 


Val Asp Val Gly Pro Pro Ala Pro Gly Ala Gly Leu Pro Val Pro Ala 
                805                 810                 815     


Leu Phe Asp Ser Leu Leu Thr Cys Arg Thr Arg Asp Ser Leu Phe Phe 
            820                 825                 830         


Cys Leu Lys Phe Cys Thr Ala Ala Ile Ser Tyr Ser Leu Cys Lys Phe 
        835                 840                 845             


Ser Ser Gln Ser Arg Asp Thr Leu Cys Ser Cys Leu Ser Pro Gly Leu 
    850                 855                 860                 


Ile Lys Lys Phe Gln Phe Leu Met Phe Arg Leu Phe Ser Glu Ala Arg 
865                 870                 875                 880 


Gln Pro Leu Ser Glu Glu Asp Val Ala Ser Leu Ser Trp Arg Pro Leu 
                885                 890                 895     


His Leu Pro Ser Ala Asp Trp Gln Arg Ala Ala Leu Ser Leu Trp Thr 
            900                 905                 910         


His Arg Thr Phe Arg Glu Val Leu Lys Glu Glu Asp Val His Leu Thr 
        915                 920                 925             


Tyr Gln Asp Trp Leu His Leu Glu Leu Glu Ile Gln Pro Glu Ala Asp 
    930                 935                 940                 


Ala Leu Ser Asp Thr Glu Arg Gln Asp Phe His Gln Trp Ala Ile His 
945                 950                 955                 960 


Glu His Phe Leu Pro Glu Ser Ser Ala Ser Gly Gly Cys Asp Gly Asp 
                965                 970                 975     


Leu Gln Ala Ala Cys Thr Ile Leu Val Asn Ala Leu Met Asp Phe His 
            980                 985                 990         


Gln Ser Ser Arg Ser Tyr Asp His  Ser Glu Asn Ser Asp  Leu Val Phe 
        995                 1000                 1005             


Gly Gly  Arg Thr Gly Asn Glu  Asp Ile Ile Ser Arg  Leu Gln Glu 
    1010                 1015                 1020             


Met Val  Ala Asp Leu Glu Leu  Gln Gln Asp Leu Ile  Val Pro Leu 
    1025                 1030                 1035             


Gly His  Thr Pro Ser Gln Glu  His Phe Leu Phe Glu  Ile Phe Arg 
    1040                 1045                 1050             


Arg Arg  Leu Gln Ala Leu Thr  Ser Gly Trp Ser Val  Ala Ala Ser 
    1055                 1060                 1065             


Leu Gln  Arg Gln Arg Glu Leu  Leu Met Tyr Lys Arg  Ile Leu Leu 
    1070                 1075                 1080             


Arg Leu  Pro Ser Ser Val Leu  Cys Gly Ser Ser Phe  Gln Ala Glu 
    1085                 1090                 1095             


Gln Pro  Ile Thr Ala Arg Cys  Glu Gln Phe Phe His  Leu Val Asn 
    1100                 1105                 1110             


Ser Glu  Met Arg Asn Phe Cys  Ser His Gly Gly Ala  Leu Thr Gln 
    1115                 1120                 1125             


Asp Ile  Thr Ala His Phe Phe  Arg Gly Leu Leu Asn  Ala Cys Leu 
    1130                 1135                 1140             


Arg Ser  Arg Asp Pro Ser Leu  Met Val Asp Phe Ile  Leu Ala Lys 
    1145                 1150                 1155             


Cys Gln  Thr Lys Cys Pro Leu  Ile Leu Thr Ser Ala  Leu Val Trp 
    1160                 1165                 1170             


Trp Pro  Ser Leu Glu Pro Val  Leu Leu Cys Arg Trp  Arg Arg His 
    1175                 1180                 1185             


Cys Gln  Ser Pro Leu Pro Arg  Glu Leu Gln Lys Leu  Gln Glu Gly 
    1190                 1195                 1200             


Arg Gln  Phe Ala Ser Asp Phe  Leu Ser Pro Glu Ala  Ala Ser Pro 
    1205                 1210                 1215             


Ala Pro  Asn Pro Asp Trp Leu  Ser Ala Ala Ala Leu  His Phe Ala 
    1220                 1225                 1230             


Ile Gln  Gln Val Arg Glu Glu  Asn Ile Arg Lys Gln  Leu Lys Lys 
    1235                 1240                 1245             


Leu Asp  Cys Glu Arg Glu Glu  Leu Leu Val Phe Leu  Phe Phe Phe 
    1250                 1255                 1260             


Ser Leu  Met Gly Leu Leu Ser  Ser His Leu Thr Ser  Asn Ser Thr 
    1265                 1270                 1275             


Thr Asp  Leu Pro Lys Ala Phe  His Val Cys Ala Ala  Ile Leu Glu 
    1280                 1285                 1290             


Cys Leu  Glu Lys Arg Lys Ile  Ser Trp Leu Ala Leu  Phe Gln Leu 
    1295                 1300                 1305             


Thr Glu  Ser Asp Leu Arg Leu  Gly Arg Leu Leu Leu  Arg Val Ala 
    1310                 1315                 1320             


Pro Asp  Gln His Thr Arg Leu  Leu Pro Phe Ala Phe  Tyr Ser Leu 
    1325                 1330                 1335             


Leu Ser  Tyr Phe His Glu Asp  Ala Ala Ile Arg Glu  Glu Ala Phe 
    1340                 1345                 1350             


Leu His  Val Ala Val Asp Met  Tyr Leu Lys Leu Val  Gln Leu Phe 
    1355                 1360                 1365             


Val Ala  Gly Asp Thr Ser Thr  Val Ser Pro Pro Ala  Gly Arg Ser 
    1370                 1375                 1380             


Leu Glu  Leu Lys Gly Gln Gly  Asn Pro Val Glu Leu  Ile Thr Lys 
    1385                 1390                 1395             


Ala Arg  Leu Phe Leu Leu Gln  Leu Ile Pro Arg Cys  Pro Lys Lys 
    1400                 1405                 1410             


Ser Phe  Ser His Val Ala Glu  Leu Leu Ala Asp Arg  Gly Asp Cys 
    1415                 1420                 1425             


Asp Pro  Glu Val Ser Ala Ala  Leu Gln Ser Arg Gln  Gln Ala Ala 
    1430                 1435                 1440             


Pro Asp  Ala Asp Leu Ser Gln  Glu Pro His Leu Phe  
    1445                 1450                 1455 


<210>  3883
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCB__Homo_sapiens__NP_001018123

<400>  3883

Met Thr Ser Lys Gln Ala Met Ser Ser Asn Glu Gln Glu Arg Leu Leu 
1               5                   10                  15      


Cys Tyr Asn Gly Glu Val Leu Val Phe Gln Leu Ser Lys Gly Asn Phe 
            20                  25                  30          


Ala Asp Lys Glu Pro Thr Lys Thr Pro Ile Leu His Val Arg Arg Met 
        35                  40                  45              


Val Phe Asp Arg Gly Thr Lys Val Phe Val Gln Lys Ser Thr Gly Phe 
    50                  55                  60                  


Phe Thr Ile Lys Glu Glu Asn Ser His Leu Lys Ile Met Cys Cys Asn 
65                  70                  75                  80  


Cys Val Ser Asp Phe Arg Thr Gly Ile Asn Leu Pro Tyr Ile Val Ile 
                85                  90                  95      


Glu Lys Asn Lys Lys Asn Asn Val Phe Glu Tyr Phe Leu Leu Ile Leu 
            100                 105                 110         


His Ser Thr Asn Lys Phe Glu Met Arg Leu Ser Phe Lys Leu Gly Tyr 
        115                 120                 125             


Glu Met Lys Asp Gly Leu Arg Val Leu Asn Gly Pro Leu Ile Leu Trp 
    130                 135                 140                 


Arg His Val Lys Ala Phe Phe Phe Ile Ser Ser Gln Thr Gly Lys Val 
145                 150                 155                 160 


Val Ser Val Ser Gly Asn Phe Ser Ser Ile Gln Trp Ala Gly Glu Ile 
                165                 170                 175     


Glu Asn Leu Gly Met Val Leu Leu Gly Leu Lys Glu Cys Cys Leu Ser 
            180                 185                 190         


Glu Glu Glu Cys Thr Gln Glu Pro Ser Lys Ser Asp Tyr Ala Ile Trp 
        195                 200                 205             


Asn Thr Lys Phe Cys Val Tyr Ser Leu Glu Ser Gln Glu Val Leu Ser 
    210                 215                 220                 


Asp Ile Tyr Ile Ile Pro Pro Ala Tyr Ser Ser Val Val Thr Tyr Val 
225                 230                 235                 240 


His Ile Cys Ala Thr Glu Ile Ile Lys Asn Gln Leu Arg Ile Ser Leu 
                245                 250                 255     


Ile Ala Leu Thr Arg Lys Asn Gln Leu Ile Ser Phe Gln Asn Gly Thr 
            260                 265                 270         


Pro Lys Asn Val Cys Gln Leu Pro Phe Gly Asp Pro Cys Ala Val Gln 
        275                 280                 285             


Leu Met Asp Ser Gly Gly Gly Asn Leu Phe Phe Val Val Ser Phe Ile 
    290                 295                 300                 


Ser Asn Asn Ala Cys Ala Val Trp Lys Glu Ser Phe Gln Val Ala Ala 
305                 310                 315                 320 


Lys Trp Glu Lys Leu Ser Leu Val Leu Ile Asp Asp Phe Ile Gly Ser 
                325                 330                 335     


Gly Thr Glu Gln Val Leu Leu Leu Phe Lys Asp Ser Leu Asn Ser Asp 
            340                 345                 350         


Cys Leu Thr Ser Phe Lys Ile Thr Asp Leu Gly Lys Ile Asn Tyr Ser 
        355                 360                 365             


Ser Glu Pro Ser Asp Cys Asn Glu Asp Asp Leu Phe Glu Asp Lys Gln 
    370                 375                 380                 


Glu Asn Arg Tyr Leu Val Val Pro Pro Leu Glu Thr Gly Leu Lys Val 
385                 390                 395                 400 


Cys Phe Ser Ser Phe Arg Glu Leu Arg Gln His Leu Leu Leu Lys Glu 
                405                 410                 415     


Lys Ile Ile Ser Lys Ser Tyr Lys Ala Leu Ile Asn Leu Val Gln Gly 
            420                 425                 430         


Lys Asp Asp Asn Thr Ser Ser Ala Glu Glu Lys Glu Cys Leu Val Pro 
        435                 440                 445             


Leu Cys Gly Glu Glu Glu Asn Ser Val His Ile Leu Asp Glu Lys Leu 
    450                 455                 460                 


Ser Asp Asn Phe Gln Asp Ser Glu Gln Leu Val Glu Lys Ile Trp Tyr 
465                 470                 475                 480 


Arg Val Ile Asp Asp Ser Leu Val Val Gly Val Lys Thr Thr Ser Ser 
                485                 490                 495     


Leu Lys Leu Ser Leu Asn Asp Val Thr Leu Ser Leu Leu Met Asp Gln 
            500                 505                 510         


Ala His Asp Ser Arg Phe Arg Leu Leu Lys Cys Gln Asn Arg Val Ile 
        515                 520                 525             


Lys Leu Ser Thr Asn Pro Phe Pro Ala Pro Tyr Leu Met Pro Cys Glu 
    530                 535                 540                 


Ile Gly Leu Glu Ala Lys Arg Val Thr Leu Thr Pro Asp Ser Lys Lys 
545                 550                 555                 560 


Glu Glu Ser Phe Val Cys Glu His Pro Ser Lys Lys Glu Cys Val Gln 
                565                 570                 575     


Ile Ile Thr Ala Val Thr Ser Leu Ser Pro Leu Leu Thr Phe Ser Lys 
            580                 585                 590         


Phe Cys Cys Thr Val Leu Leu Gln Ile Met Glu Arg Glu Ser Gly Asn 
        595                 600                 605             


Cys Pro Lys Asp Arg Tyr Val Val Cys Gly Arg Val Phe Leu Ser Leu 
    610                 615                 620                 


Glu Asp Leu Ser Thr Gly Lys Tyr Leu Leu Thr Phe Pro Lys Lys Lys 
625                 630                 635                 640 


Pro Ile Glu His Met Glu Asp Leu Phe Ala Leu Leu Ala Ala Phe His 
                645                 650                 655     


Lys Ser Cys Phe Gln Ile Thr Ser Pro Gly Tyr Ala Leu Asn Ser Met 
            660                 665                 670         


Lys Val Trp Leu Leu Glu His Met Lys Cys Glu Ile Ile Lys Glu Phe 
        675                 680                 685             


Pro Glu Val Tyr Phe Cys Glu Arg Pro Gly Ser Phe Tyr Gly Thr Leu 
    690                 695                 700                 


Phe Thr Trp Lys Gln Arg Thr Pro Phe Glu Gly Ile Leu Ile Ile Tyr 
705                 710                 715                 720 


Ser Arg Asn Gln Thr Val Met Phe Gln Cys Leu His Asn Leu Ile Arg 
                725                 730                 735     


Ile Leu Pro Ile Asn Cys Phe Leu Lys Asn Leu Lys Ser Gly Ser Glu 
            740                 745                 750         


Asn Phe Leu Ile Asp Asn Met Ala Phe Thr Leu Glu Lys Glu Leu Val 
        755                 760                 765             


Thr Leu Ser Ser Leu Ser Ser Ala Ile Ala Lys His Glu Ser Asn Phe 
    770                 775                 780                 


Met Gln Arg Cys Glu Val Ser Lys Gly Lys Ser Ser Val Val Ala Ala 
785                 790                 795                 800 


Ala Leu Ser Asp Arg Arg Glu Asn Ile His Pro Tyr Arg Lys Glu Leu 
                805                 810                 815     


Gln Arg Glu Lys Lys Lys Met Leu Gln Thr Asn Leu Lys Val Ser Gly 
            820                 825                 830         


Ala Leu Tyr Arg Glu Ile Thr Leu Lys Val Ala Glu Val Gln Leu Lys 
        835                 840                 845             


Ser Asp Phe Ala Ala Gln Lys Leu Ser Asn Leu 
    850                 855                 


<210>  3884
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCC__Homo_sapiens__NP_001230672

<400>  3884

Met Ala Gln Asp Ser Val Asp Leu Ser Cys Asp Tyr Gln Phe Trp Met 
1               5                   10                  15      


Gln Lys Leu Ser Val Trp Asp Gln Ala Ser Thr Leu Glu Thr Gln Gln 
            20                  25                  30          


Asp Thr Cys Leu His Val Ala Gln Phe Gln Glu Phe Leu Arg Lys Met 
        35                  40                  45              


Tyr Glu Ala Leu Lys Glu Met Asp Ser Asn Thr Val Ile Glu Arg Phe 
    50                  55                  60                  


Pro Thr Ile Gly Gln Leu Leu Ala Lys Ala Cys Trp Asn Pro Phe Ile 
65                  70                  75                  80  


Leu Ala Tyr Asp Glu Ser Gln Lys Ile Leu Ile Trp Cys Leu Cys Cys 
                85                  90                  95      


Leu Ile Asn Lys Glu Pro Gln Asn Ser Gly Gln Ser Lys Leu Asn Ser 
            100                 105                 110         


Trp Ile Gln Gly Val Leu Ser His Ile Leu Ser Ala Leu Arg Phe Asp 
        115                 120                 125             


Lys Glu Val Ala Leu Phe Thr Gln Gly Leu Gly Tyr Ala Pro Ile Asp 
    130                 135                 140                 


Tyr Tyr Pro Gly Leu Leu Lys Asn Met Val Leu Ser Leu Ala Ser Glu 
145                 150                 155                 160 


Leu Arg Glu Asn His Leu Asn Gly Phe Asn Thr Gln Arg Arg Met Ala 
                165                 170                 175     


Pro Glu Arg Val Ala Ser Leu Ser Arg Val Cys Val Pro Leu Ile Thr 
            180                 185                 190         


Leu Thr Asp Val Asp Pro Leu Val Glu Ala Leu Leu Ile Cys His Gly 
        195                 200                 205             


Arg Glu Pro Gln Glu Ile Leu Gln Pro Glu Phe Phe Glu Ala Val Asn 
    210                 215                 220                 


Glu Ala Ile Leu Leu Lys Lys Ile Ser Leu Pro Met Ser Ala Val Val 
225                 230                 235                 240 


Cys Leu Trp Leu Arg His Leu Pro Ser Leu Glu Lys Ala Met Leu His 
                245                 250                 255     


Leu Phe Glu Lys Leu Ile Ser Ser Glu Arg Asn Cys Leu Arg Arg Ile 
            260                 265                 270         


Glu Cys Phe Ile Lys Asp Ser Ser Leu Pro Gln Ala Ala Cys His Pro 
        275                 280                 285             


Ala Ile Phe Arg Val Val Asp Glu Met Phe Arg Cys Ala Leu Leu Glu 
    290                 295                 300                 


Thr Asp Gly Ala Leu Glu Ile Ile Ala Thr Ile Gln Val Phe Thr Gln 
305                 310                 315                 320 


Cys Phe Val Glu Ala Leu Glu Lys Ala Ser Lys Gln Leu Arg Phe Ala 
                325                 330                 335     


Leu Lys Thr Tyr Phe Pro Tyr Thr Ser Pro Ser Leu Ala Met Val Leu 
            340                 345                 350         


Leu Gln Asp Pro Gln Asp Ile Pro Arg Gly His Trp Leu Gln Thr Leu 
        355                 360                 365             


Lys His Ile Ser Glu Leu Leu Arg Glu Ala Val Glu Asp Gln Thr His 
    370                 375                 380                 


Gly Ser Cys Gly Gly Pro Phe Glu Ser Trp Phe Leu Phe Ile His Phe 
385                 390                 395                 400 


Gly Gly Trp Ala Glu Met Val Ala Glu Gln Leu Leu Met Ser Ala Ala 
                405                 410                 415     


Glu Pro Pro Thr Ala Leu Leu Trp Leu Leu Ala Phe Tyr Tyr Gly Pro 
            420                 425                 430         


Arg Asp Gly Arg Gln Gln Arg Ala Gln Thr Met Val Gln Val Lys Ala 
        435                 440                 445             


Val Leu Gly His Leu Leu Ala Met Ser Arg Ser Ser Ser Leu Ser Ala 
    450                 455                 460                 


Gln Asp Leu Gln Thr Val Ala Gly Gln Gly Thr Asp Thr Asp Leu Arg 
465                 470                 475                 480 


Ala Pro Ala Gln Gln Leu Ile Arg His Leu Leu Leu Asn Phe Leu Leu 
                485                 490                 495     


Trp Ala Pro Gly Gly His Thr Ile Ala Trp Asp Val Ile Thr Leu Met 
            500                 505                 510         


Ala His Thr Ala Glu Ile Thr His Glu Ile Ile Gly Phe Leu Asp Gln 
        515                 520                 525             


Thr Leu Tyr Arg Trp Asn Arg Leu Gly Ile Glu Ser Pro Arg Ser Glu 
    530                 535                 540                 


Lys Leu Ala Arg Glu Leu Leu Lys Glu Leu Arg Thr Gln Val 
545                 550                 555             


<210>  3885
<211>  1451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCD2__Homo_sapiens__NP_001018125

<400>  3885

Met Val Ser Lys Arg Arg Leu Ser Lys Ser Glu Asp Lys Glu Ser Leu 
1               5                   10                  15      


Thr Glu Asp Ala Ser Lys Thr Arg Lys Gln Pro Leu Ser Lys Lys Thr 
            20                  25                  30          


Lys Lys Ser His Ile Ala Asn Glu Val Glu Glu Asn Asp Ser Ile Phe 
        35                  40                  45              


Val Lys Leu Leu Lys Ile Ser Gly Ile Ile Leu Lys Thr Gly Glu Ser 
    50                  55                  60                  


Gln Asn Gln Leu Ala Val Asp Gln Ile Ala Phe Gln Lys Lys Leu Phe 
65                  70                  75                  80  


Gln Thr Leu Arg Arg His Pro Ser Tyr Pro Lys Ile Ile Glu Glu Phe 
                85                  90                  95      


Val Ser Gly Leu Glu Ser Tyr Ile Glu Asp Glu Asp Ser Phe Arg Asn 
            100                 105                 110         


Cys Leu Leu Ser Cys Glu Arg Leu Gln Asp Glu Glu Ala Ser Met Gly 
        115                 120                 125             


Ala Ser Tyr Ser Lys Ser Leu Ile Lys Leu Leu Leu Gly Ile Asp Ile 
    130                 135                 140                 


Leu Gln Pro Ala Ile Ile Lys Thr Leu Phe Glu Lys Leu Pro Glu Tyr 
145                 150                 155                 160 


Phe Phe Glu Asn Lys Asn Ser Asp Glu Ile Asn Ile Pro Arg Leu Ile 
                165                 170                 175     


Val Ser Gln Leu Lys Trp Leu Asp Arg Val Val Asp Gly Lys Asp Leu 
            180                 185                 190         


Thr Thr Lys Ile Met Gln Leu Ile Ser Ile Ala Pro Glu Asn Leu Gln 
        195                 200                 205             


His Asp Ile Ile Thr Ser Leu Pro Glu Ile Leu Gly Asp Ser Gln His 
    210                 215                 220                 


Ala Asp Val Gly Lys Glu Leu Ser Asp Leu Leu Ile Glu Asn Thr Ser 
225                 230                 235                 240 


Leu Thr Val Pro Ile Leu Asp Val Leu Ser Ser Leu Arg Leu Asp Pro 
                245                 250                 255     


Asn Phe Leu Leu Lys Val Arg Gln Leu Val Met Asp Lys Leu Ser Ser 
            260                 265                 270         


Ile Arg Leu Glu Asp Leu Pro Val Ile Ile Lys Phe Ile Leu His Ser 
        275                 280                 285             


Val Thr Ala Met Asp Thr Leu Glu Val Ile Ser Glu Leu Arg Glu Lys 
    290                 295                 300                 


Leu Asp Leu Gln His Cys Val Leu Pro Ser Arg Leu Gln Ala Ser Gln 
305                 310                 315                 320 


Val Lys Leu Lys Ser Lys Gly Arg Ala Ser Ser Ser Gly Asn Gln Glu 
                325                 330                 335     


Ser Ser Gly Gln Ser Cys Ile Ile Leu Leu Phe Asp Val Ile Lys Ser 
            340                 345                 350         


Ala Ile Arg Tyr Glu Lys Thr Ile Ser Glu Ala Trp Ile Lys Ala Ile 
        355                 360                 365             


Glu Asn Thr Ala Ser Val Ser Glu His Lys Val Phe Asp Leu Val Met 
    370                 375                 380                 


Leu Phe Ile Ile Tyr Ser Thr Asn Thr Gln Thr Lys Lys Tyr Ile Asp 
385                 390                 395                 400 


Arg Val Leu Arg Asn Lys Ile Arg Ser Gly Cys Ile Gln Glu Gln Leu 
                405                 410                 415     


Leu Gln Ser Thr Phe Ser Val His Tyr Leu Val Leu Lys Asp Met Cys 
            420                 425                 430         


Ser Ser Ile Leu Ser Leu Ala Gln Ser Leu Leu His Ser Leu Asp Gln 
        435                 440                 445             


Ser Ile Ile Ser Phe Gly Ser Leu Leu Tyr Lys Tyr Ala Phe Lys Phe 
    450                 455                 460                 


Phe Asp Thr Tyr Cys Gln Gln Glu Val Val Gly Ala Leu Val Thr His 
465                 470                 475                 480 


Ile Cys Ser Gly Asn Glu Ala Glu Val Asp Thr Ala Leu Asp Val Leu 
                485                 490                 495     


Leu Glu Leu Val Val Leu Asn Pro Ser Ala Met Met Met Asn Ala Val 
            500                 505                 510         


Phe Val Lys Gly Ile Leu Asp Tyr Leu Asp Asn Ile Ser Pro Gln Gln 
        515                 520                 525             


Ile Arg Lys Leu Phe Tyr Val Leu Ser Thr Leu Ala Phe Ser Lys Gln 
    530                 535                 540                 


Asn Glu Ala Ser Ser His Ile Gln Asp Asp Met His Leu Val Ile Arg 
545                 550                 555                 560 


Lys Gln Leu Ser Ser Thr Val Phe Lys Tyr Lys Leu Ile Gly Ile Ile 
                565                 570                 575     


Gly Ala Val Thr Met Ala Gly Ile Met Ala Ala Asp Arg Ser Glu Ser 
            580                 585                 590         


Pro Ser Leu Thr Gln Glu Arg Ala Asn Leu Ser Asp Glu Gln Cys Thr 
        595                 600                 605             


Gln Val Thr Ser Leu Leu Gln Leu Val His Ser Cys Ser Glu Gln Ser 
    610                 615                 620                 


Pro Gln Ala Ser Ala Leu Tyr Tyr Asp Glu Phe Ala Asn Leu Ile Gln 
625                 630                 635                 640 


His Glu Lys Leu Asp Pro Lys Ala Leu Glu Trp Val Gly His Thr Ile 
                645                 650                 655     


Cys Asn Asp Phe Gln Asp Ala Phe Val Val Asp Ser Cys Val Val Pro 
            660                 665                 670         


Glu Gly Asp Phe Pro Phe Pro Val Lys Ala Leu Tyr Gly Leu Glu Glu 
        675                 680                 685             


Tyr Asp Thr Gln Asp Gly Ile Ala Ile Asn Leu Leu Pro Leu Leu Phe 
    690                 695                 700                 


Ser Gln Asp Phe Ala Lys Asp Gly Gly Pro Val Thr Ser Gln Glu Ser 
705                 710                 715                 720 


Gly Gln Lys Leu Val Ser Pro Leu Cys Leu Ala Pro Tyr Phe Arg Leu 
                725                 730                 735     


Leu Arg Leu Cys Val Glu Arg Gln His Asn Gly Asn Leu Glu Glu Ile 
            740                 745                 750         


Asp Gly Leu Leu Asp Cys Pro Ile Phe Leu Thr Asp Leu Glu Pro Gly 
        755                 760                 765             


Glu Lys Leu Glu Ser Met Ser Ala Lys Glu Arg Ser Phe Met Cys Ser 
    770                 775                 780                 


Leu Ile Phe Leu Thr Leu Asn Trp Phe Arg Glu Ile Val Asn Ala Phe 
785                 790                 795                 800 


Cys Gln Glu Thr Ser Pro Glu Met Lys Gly Lys Val Leu Thr Arg Leu 
                805                 810                 815     


Lys His Ile Val Glu Leu Gln Ile Ile Leu Glu Lys Tyr Leu Ala Val 
            820                 825                 830         


Thr Pro Asp Tyr Val Pro Pro Leu Gly Asn Phe Asp Val Glu Thr Leu 
        835                 840                 845             


Asp Ile Thr Pro His Thr Val Thr Ala Ile Ser Ala Lys Ile Arg Lys 
    850                 855                 860                 


Lys Gly Lys Ile Glu Arg Lys Gln Lys Thr Asp Gly Ser Lys Thr Ser 
865                 870                 875                 880 


Ser Ser Asp Thr Leu Ser Glu Glu Lys Asn Ser Glu Cys Asp Pro Thr 
                885                 890                 895     


Pro Ser His Arg Gly Gln Leu Asn Lys Glu Phe Thr Gly Lys Glu Glu 
            900                 905                 910         


Lys Thr Ser Leu Leu Leu His Asn Ser His Ala Phe Phe Arg Glu Leu 
        915                 920                 925             


Asp Ile Glu Val Phe Ser Ile Leu His Cys Gly Leu Val Thr Lys Phe 
    930                 935                 940                 


Ile Leu Asp Thr Glu Met His Thr Glu Ala Thr Glu Val Val Gln Leu 
945                 950                 955                 960 


Gly Pro Pro Glu Leu Leu Phe Leu Leu Glu Asp Leu Ser Gln Lys Leu 
                965                 970                 975     


Glu Ser Met Leu Thr Pro Pro Ile Ala Arg Arg Val Pro Phe Leu Lys 
            980                 985                 990         


Asn Lys Gly Ser Arg Asn Ile Gly  Phe Ser His Leu Gln  Gln Arg Ser 
        995                 1000                 1005             


Ala Gln  Glu Ile Val His Cys  Val Phe Gln Leu Leu  Thr Pro Met 
    1010                 1015                 1020             


Cys Asn  His Leu Glu Asn Ile  His Asn Tyr Phe Gln  Cys Leu Ala 
    1025                 1030                 1035             


Ala Glu  Asn His Gly Val Val  Asp Gly Pro Gly Val  Lys Val Gln 
    1040                 1045                 1050             


Glu Tyr  His Ile Met Ser Ser  Cys Tyr Gln Arg Leu  Leu Gln Ile 
    1055                 1060                 1065             


Phe His  Gly Leu Phe Ala Trp  Ser Gly Phe Ser Gln  Pro Glu Asn 
    1070                 1075                 1080             


Gln Asn  Leu Leu Tyr Ser Ala  Leu His Val Leu Ser  Ser Arg Leu 
    1085                 1090                 1095             


Lys Gln  Gly Glu His Ser Gln  Pro Leu Glu Glu Leu  Leu Ser Gln 
    1100                 1105                 1110             


Ser Val  His Tyr Leu Gln Asn  Phe His Gln Ser Ile  Pro Ser Phe 
    1115                 1120                 1125             


Gln Cys  Ala Leu Tyr Leu Ile  Arg Leu Leu Met Val  Ile Leu Glu 
    1130                 1135                 1140             


Lys Ser  Thr Ala Ser Ala Gln  Asn Lys Glu Lys Ile  Ala Ser Leu 
    1145                 1150                 1155             


Ala Arg  Gln Phe Leu Cys Arg  Val Trp Pro Ser Gly  Asp Lys Glu 
    1160                 1165                 1170             


Lys Ser  Asn Ile Ser Asn Asp  Gln Leu His Ala Leu  Leu Cys Ile 
    1175                 1180                 1185             


Tyr Leu  Glu His Thr Glu Ser  Ile Leu Lys Ala Ile  Glu Glu Ile 
    1190                 1195                 1200             


Ala Gly  Val Gly Val Pro Glu  Leu Ile Asn Ser Pro  Lys Asp Ala 
    1205                 1210                 1215             


Ser Ser  Ser Thr Phe Pro Thr  Leu Thr Arg His Thr  Phe Val Val 
    1220                 1225                 1230             


Phe Phe  Arg Val Met Met Ala  Glu Leu Glu Lys Thr  Val Lys Lys 
    1235                 1240                 1245             


Ile Glu  Pro Gly Thr Ala Ala  Asp Ser Gln Gln Ile  His Glu Glu 
    1250                 1255                 1260             


Lys Leu  Leu Tyr Trp Asn Met  Ala Val Arg Asp Phe  Ser Ile Leu 
    1265                 1270                 1275             


Ile Asn  Leu Ile Lys Val Phe  Asp Ser His Pro Val  Leu His Val 
    1280                 1285                 1290             


Cys Leu  Lys Tyr Gly Arg Leu  Phe Val Glu Ala Phe  Leu Lys Gln 
    1295                 1300                 1305             


Cys Met  Pro Leu Leu Asp Phe  Ser Phe Arg Lys His  Arg Glu Asp 
    1310                 1315                 1320             


Val Leu  Ser Leu Leu Glu Thr  Phe Gln Leu Asp Thr  Arg Leu Leu 
    1325                 1330                 1335             


His His  Leu Cys Gly His Ser  Lys Ile His Gln Asp  Thr Arg Leu 
    1340                 1345                 1350             


Thr Gln  His Val Pro Leu Leu  Lys Lys Thr Leu Glu  Leu Leu Val 
    1355                 1360                 1365             


Cys Arg  Val Lys Ala Met Leu  Thr Leu Asn Asn Cys  Arg Glu Ala 
    1370                 1375                 1380             


Phe Trp  Leu Gly Asn Leu Lys  Asn Arg Asp Leu Gln  Gly Glu Glu 
    1385                 1390                 1395             


Ile Lys  Ser Gln Asn Ser Gln  Glu Ser Thr Ala Asp  Glu Ser Glu 
    1400                 1405                 1410             


Asp Asp  Met Ser Ser Gln Ala  Ser Lys Ser Lys Ala  Thr Glu Asp 
    1415                 1420                 1425             


Gly Glu  Glu Asp Glu Val Ser  Ala Gly Glu Lys Glu  Gln Asp Ser 
    1430                 1435                 1440             


Asp Glu  Ser Tyr Asp Asp Ser  Asp 
    1445                 1450     


<210>  3886
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCE__Homo_sapiens__NP_068741

<400>  3886

Met Ala Thr Pro Asp Ala Gly Leu Pro Gly Ala Glu Gly Val Glu Pro 
1               5                   10                  15      


Ala Pro Trp Ala Gln Leu Glu Ala Pro Ala Arg Leu Leu Leu Gln Ala 
            20                  25                  30          


Leu Gln Ala Gly Pro Glu Gly Ala Arg Arg Gly Leu Gly Val Leu Arg 
        35                  40                  45              


Ala Leu Gly Ser Arg Gly Trp Glu Pro Phe Asp Trp Gly Arg Leu Leu 
    50                  55                  60                  


Glu Ala Leu Cys Arg Glu Glu Pro Val Val Gln Gly Pro Asp Gly Arg 
65                  70                  75                  80  


Leu Glu Leu Lys Pro Leu Leu Leu Arg Leu Pro Arg Ile Cys Gln Arg 
                85                  90                  95      


Asn Leu Met Ser Leu Leu Met Ala Val Arg Pro Ser Leu Pro Glu Ser 
            100                 105                 110         


Gly Leu Leu Ser Val Leu Gln Ile Ala Gln Gln Asp Leu Ala Pro Asp 
        115                 120                 125             


Pro Asp Ala Trp Leu Arg Ala Leu Gly Glu Leu Leu Arg Arg Asp Leu 
    130                 135                 140                 


Gly Val Gly Thr Ser Met Glu Gly Ala Ser Pro Leu Ser Glu Arg Cys 
145                 150                 155                 160 


Gln Arg Gln Leu Gln Ser Leu Cys Arg Gly Leu Gly Leu Gly Gly Arg 
                165                 170                 175     


Arg Leu Lys Ser Pro Gln Ala Pro Asp Pro Glu Glu Glu Glu Asn Arg 
            180                 185                 190         


Asp Ser Gln Gln Pro Gly Lys Arg Arg Lys Asp Ser Glu Glu Glu Ala 
        195                 200                 205             


Ala Ser Pro Glu Gly Lys Arg Val Pro Lys Arg Leu Arg Cys Trp Glu 
    210                 215                 220                 


Glu Glu Glu Asp His Glu Lys Glu Arg Pro Glu His Lys Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ala Asp Gly Gly Ser Ala Ser Pro Ile Lys Asp Gln Pro Val 
                245                 250                 255     


Met Ala Val Lys Thr Gly Glu Asp Gly Ser Asn Leu Asp Asp Ala Lys 
            260                 265                 270         


Gly Leu Ala Glu Ser Leu Glu Leu Pro Lys Ala Ile Gln Asp Gln Leu 
        275                 280                 285             


Pro Arg Leu Gln Gln Leu Leu Lys Thr Leu Glu Glu Gly Leu Glu Gly 
    290                 295                 300                 


Leu Glu Asp Ala Pro Pro Val Glu Leu Gln Leu Leu His Glu Cys Ser 
305                 310                 315                 320 


Pro Ser Gln Met Asp Leu Leu Cys Ala Gln Leu Gln Leu Pro Gln Leu 
                325                 330                 335     


Ser Asp Leu Gly Leu Leu Arg Leu Cys Thr Trp Leu Leu Ala Leu Ser 
            340                 345                 350         


Pro Asp Leu Ser Leu Ser Asn Ala Thr Val Leu Thr Arg Ser Leu Phe 
        355                 360                 365             


Leu Gly Arg Ile Leu Ser Leu Thr Ser Ser Ala Ser Arg Leu Leu Thr 
    370                 375                 380                 


Thr Ala Leu Thr Ser Phe Cys Ala Lys Tyr Thr Tyr Pro Val Cys Ser 
385                 390                 395                 400 


Ala Leu Leu Asp Pro Val Leu Gln Ala Pro Gly Thr Gly Pro Ala Gln 
                405                 410                 415     


Thr Glu Leu Leu Cys Cys Leu Val Lys Met Glu Ser Leu Glu Pro Asp 
            420                 425                 430         


Ala Gln Val Leu Met Leu Gly Gln Ile Leu Glu Leu Pro Trp Lys Glu 
        435                 440                 445             


Glu Thr Phe Leu Val Leu Gln Ser Leu Leu Glu Arg Gln Val Glu Met 
    450                 455                 460                 


Thr Pro Glu Lys Phe Ser Val Leu Met Glu Lys Leu Cys Lys Lys Gly 
465                 470                 475                 480 


Leu Ala Ala Thr Thr Ser Met Ala Tyr Ala Lys Leu Met Leu Thr Val 
                485                 490                 495     


Met Thr Lys Tyr Gln Ala Asn Ile Thr Glu Thr Gln Arg Leu Gly Leu 
            500                 505                 510         


Ala Met Ala Leu Glu Pro Asn Thr Thr Phe Leu Arg Lys Ser Leu Lys 
        515                 520                 525             


Ala Ala Leu Lys His Leu Gly Pro 
    530                 535     


<210>  3887
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCF__Homo_sapiens__NP_073562

<400>  3887

Met Glu Ser Leu Leu Gln His Leu Asp Arg Phe Ser Glu Leu Leu Ala 
1               5                   10                  15      


Val Ser Ser Thr Thr Tyr Val Ser Thr Trp Asp Pro Ala Thr Val Arg 
            20                  25                  30          


Arg Ala Leu Gln Trp Ala Arg Tyr Leu Arg His Ile His Arg Arg Phe 
        35                  40                  45              


Gly Arg His Gly Pro Ile Arg Thr Ala Leu Glu Arg Arg Leu His Asn 
    50                  55                  60                  


Gln Trp Arg Gln Glu Gly Gly Phe Gly Arg Gly Pro Val Pro Gly Leu 
65                  70                  75                  80  


Ala Asn Phe Gln Ala Leu Gly His Cys Asp Val Leu Leu Ser Leu Arg 
                85                  90                  95      


Leu Leu Glu Asn Arg Ala Leu Gly Asp Ala Ala Arg Tyr His Leu Val 
            100                 105                 110         


Gln Gln Leu Phe Pro Gly Pro Gly Val Arg Asp Ala Asp Glu Glu Thr 
        115                 120                 125             


Leu Gln Glu Ser Leu Ala Arg Leu Ala Arg Arg Arg Ser Ala Val His 
    130                 135                 140                 


Met Leu Arg Phe Asn Gly Tyr Arg Glu Asn Pro Asn Leu Gln Glu Asp 
145                 150                 155                 160 


Ser Leu Met Lys Thr Gln Ala Glu Leu Leu Leu Glu Arg Leu Gln Glu 
                165                 170                 175     


Val Gly Lys Ala Glu Ala Glu Arg Pro Ala Arg Phe Leu Ser Ser Leu 
            180                 185                 190         


Trp Glu Arg Leu Pro Gln Asn Asn Phe Leu Lys Val Ile Ala Val Ala 
        195                 200                 205             


Leu Leu Gln Pro Pro Leu Ser Arg Arg Pro Gln Glu Glu Leu Glu Pro 
    210                 215                 220                 


Gly Ile His Lys Ser Pro Gly Glu Gly Ser Gln Val Leu Val His Trp 
225                 230                 235                 240 


Leu Leu Gly Asn Ser Glu Val Phe Ala Ala Phe Cys Arg Ala Leu Pro 
                245                 250                 255     


Ala Gly Leu Leu Thr Leu Val Thr Ser Arg His Pro Ala Leu Ser Pro 
            260                 265                 270         


Val Tyr Leu Gly Leu Leu Thr Asp Trp Gly Gln Arg Leu His Tyr Asp 
        275                 280                 285             


Leu Gln Lys Gly Ile Trp Val Gly Thr Glu Ser Gln Asp Val Pro Trp 
    290                 295                 300                 


Glu Glu Leu His Asn Arg Phe Gln Ser Leu Cys Gln Ala Pro Pro Pro 
305                 310                 315                 320 


Leu Lys Asp Lys Val Leu Thr Ala Leu Glu Thr Cys Lys Ala Gln Asp 
                325                 330                 335     


Gly Asp Phe Glu Val Pro Gly Leu Ser Ile Trp Thr Asp Leu Leu Leu 
            340                 345                 350         


Ala Leu Arg Ser Gly Ala Phe Arg Lys Arg Gln Val Leu Gly Leu Ser 
        355                 360                 365             


Ala Gly Leu Ser Ser Val 
    370                 


<210>  3888
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCG__Homo_sapiens__NP_004620

<400>  3888

Met Ser Arg Gln Thr Thr Ser Val Gly Ser Ser Cys Leu Asp Leu Trp 
1               5                   10                  15      


Arg Glu Lys Asn Asp Arg Leu Val Arg Gln Ala Lys Val Ala Gln Asn 
            20                  25                  30          


Ser Gly Leu Thr Leu Arg Arg Gln Gln Leu Ala Gln Asp Ala Leu Glu 
        35                  40                  45              


Gly Leu Arg Gly Leu Leu His Ser Leu Gln Gly Leu Pro Ala Ala Val 
    50                  55                  60                  


Pro Val Leu Pro Leu Glu Leu Thr Val Thr Cys Asn Phe Ile Ile Leu 
65                  70                  75                  80  


Arg Ala Ser Leu Ala Gln Gly Phe Thr Glu Asp Gln Ala Gln Asp Ile 
                85                  90                  95      


Gln Arg Ser Leu Glu Arg Val Leu Glu Thr Gln Glu Gln Gln Gly Pro 
            100                 105                 110         


Arg Leu Glu Gln Gly Leu Arg Glu Leu Trp Asp Ser Val Leu Arg Ala 
        115                 120                 125             


Ser Cys Leu Leu Pro Glu Leu Leu Ser Ala Leu His Arg Leu Val Gly 
    130                 135                 140                 


Leu Gln Ala Ala Leu Trp Leu Ser Ala Asp Arg Leu Gly Asp Leu Ala 
145                 150                 155                 160 


Leu Leu Leu Glu Thr Leu Asn Gly Ser Gln Ser Gly Ala Ser Lys Asp 
                165                 170                 175     


Leu Leu Leu Leu Leu Lys Thr Trp Ser Pro Pro Ala Glu Glu Leu Asp 
            180                 185                 190         


Ala Pro Leu Thr Leu Gln Asp Ala Gln Gly Leu Lys Asp Val Leu Leu 
        195                 200                 205             


Thr Ala Phe Ala Tyr Arg Gln Gly Leu Gln Glu Leu Ile Thr Gly Asn 
    210                 215                 220                 


Pro Asp Lys Ala Leu Ser Ser Leu His Glu Ala Ala Ser Gly Leu Cys 
225                 230                 235                 240 


Pro Arg Pro Val Leu Val Gln Val Tyr Thr Ala Leu Gly Ser Cys His 
                245                 250                 255     


Arg Lys Met Gly Asn Pro Gln Arg Ala Leu Leu Tyr Leu Val Ala Ala 
            260                 265                 270         


Leu Lys Glu Gly Ser Ala Trp Gly Pro Pro Leu Leu Glu Ala Ser Arg 
        275                 280                 285             


Leu Tyr Gln Gln Leu Gly Asp Thr Thr Ala Glu Leu Glu Ser Leu Glu 
    290                 295                 300                 


Leu Leu Val Glu Ala Leu Asn Val Pro Cys Ser Ser Lys Ala Pro Gln 
305                 310                 315                 320 


Phe Leu Ile Glu Val Glu Leu Leu Leu Pro Pro Pro Asp Leu Ala Ser 
                325                 330                 335     


Pro Leu His Cys Gly Thr Gln Ser Gln Thr Lys His Ile Leu Ala Ser 
            340                 345                 350         


Arg Cys Leu Gln Thr Gly Arg Ala Gly Asp Ala Ala Glu His Tyr Leu 
        355                 360                 365             


Asp Leu Leu Ala Leu Leu Leu Asp Ser Ser Glu Pro Arg Phe Ser Pro 
    370                 375                 380                 


Pro Pro Ser Pro Pro Gly Pro Cys Met Pro Glu Val Phe Leu Glu Ala 
385                 390                 395                 400 


Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp Ala Leu Thr Leu 
                405                 410                 415     


Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu Pro Lys Met Ser 
            420                 425                 430         


Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu Leu Pro Tyr Cys 
        435                 440                 445             


Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly Gln Ala Trp Val 
    450                 455                 460                 


Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe Ser Arg Cys Leu 
465                 470                 475                 480 


Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu Gln Gly Ala Ala 
                485                 490                 495     


Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala Leu Gln Gln Leu 
            500                 505                 510         


Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu Trp Val Ala Ser Gly 
        515                 520                 525             


Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu Ser Val Gln Met Cys 
    530                 535                 540                 


Pro Gly Asn Arg Asp Thr Tyr Phe His Leu Leu Gln Thr Leu Lys Arg 
545                 550                 555                 560 


Leu Asp Arg Arg Asp Glu Ala Thr Ala Leu Trp Trp Arg Leu Glu Ala 
                565                 570                 575     


Gln Thr Lys Gly Ser His Glu Asp Ala Leu Trp Ser Leu Pro Leu Tyr 
            580                 585                 590         


Leu Glu Ser Tyr Leu Ser Trp Ile Arg Pro Ser Asp Arg Asp Ala Phe 
        595                 600                 605             


Leu Glu Glu Phe Arg Thr Ser Leu Pro Lys Ser Cys Asp Leu 
    610                 615                 620         


<210>  3889
<211>  1328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCI__Homo_sapiens__NP_001106849

<400>  3889

Met Asp Gln Lys Ile Leu Ser Leu Ala Ala Glu Lys Thr Ala Asp Lys 
1               5                   10                  15      


Leu Gln Glu Phe Leu Gln Thr Leu Arg Glu Gly Asp Leu Thr Asn Leu 
            20                  25                  30          


Leu Gln Asn Gln Ala Val Lys Gly Lys Val Ala Gly Ala Leu Leu Arg 
        35                  40                  45              


Ala Ile Phe Lys Gly Ser Pro Cys Ser Glu Glu Ala Gly Thr Leu Arg 
    50                  55                  60                  


Arg Arg Lys Ile Tyr Thr Cys Cys Ile Gln Leu Val Glu Ser Gly Asp 
65                  70                  75                  80  


Leu Gln Lys Glu Ile Ala Ser Glu Ile Ile Gly Leu Leu Met Leu Glu 
                85                  90                  95      


Ala His His Phe Pro Gly Pro Leu Leu Val Glu Leu Ala Asn Glu Phe 
            100                 105                 110         


Ile Ser Ala Val Arg Glu Gly Ser Leu Val Asn Gly Lys Ser Leu Glu 
        115                 120                 125             


Leu Leu Pro Ile Ile Leu Thr Ala Leu Ala Thr Lys Lys Glu Asn Leu 
    130                 135                 140                 


Ala Tyr Gly Lys Gly Val Leu Ser Gly Glu Glu Cys Lys Lys Gln Leu 
145                 150                 155                 160 


Ile Asn Thr Leu Cys Ser Gly Arg Trp Asp Gln Gln Tyr Val Ile Gln 
                165                 170                 175     


Leu Thr Ser Met Phe Lys Asp Val Pro Leu Thr Ala Glu Glu Val Glu 
            180                 185                 190         


Phe Val Val Glu Lys Ala Leu Ser Met Phe Ser Lys Met Asn Leu Gln 
        195                 200                 205             


Glu Ile Pro Pro Leu Val Tyr Gln Leu Leu Val Leu Ser Ser Lys Gly 
    210                 215                 220                 


Ser Arg Lys Ser Val Leu Glu Gly Ile Ile Ala Phe Phe Ser Ala Leu 
225                 230                 235                 240 


Asp Lys Gln His Asn Glu Glu Gln Ser Gly Asp Glu Leu Leu Asp Val 
                245                 250                 255     


Val Thr Val Pro Ser Gly Glu Leu Arg His Val Glu Gly Thr Ile Ile 
            260                 265                 270         


Leu His Ile Val Phe Ala Ile Lys Leu Asp Tyr Glu Leu Gly Arg Glu 
        275                 280                 285             


Leu Val Lys His Leu Lys Val Gly Gln Gln Gly Asp Ser Asn Asn Asn 
    290                 295                 300                 


Leu Ser Pro Phe Ser Ile Ala Leu Leu Leu Ser Val Thr Arg Ile Gln 
305                 310                 315                 320 


Arg Phe Gln Asp Gln Val Leu Asp Leu Leu Lys Thr Ser Val Val Lys 
                325                 330                 335     


Ser Phe Lys Asp Leu Gln Leu Leu Gln Gly Ser Lys Phe Leu Gln Asn 
            340                 345                 350         


Leu Val Pro His Arg Ser Tyr Val Ser Thr Met Ile Leu Glu Val Val 
        355                 360                 365             


Lys Asn Ser Val His Ser Trp Asp His Val Thr Gln Gly Leu Val Glu 
    370                 375                 380                 


Leu Gly Phe Ile Leu Met Asp Ser Tyr Gly Pro Lys Lys Val Leu Asp 
385                 390                 395                 400 


Gly Lys Thr Ile Glu Thr Ser Pro Ser Leu Ser Arg Met Pro Asn Gln 
                405                 410                 415     


His Ala Cys Lys Leu Gly Ala Asn Ile Leu Leu Glu Thr Phe Lys Ile 
            420                 425                 430         


His Glu Met Ile Arg Gln Glu Ile Leu Glu Gln Val Leu Asn Arg Val 
        435                 440                 445             


Val Thr Arg Ala Ser Ser Pro Ile Ser His Phe Leu Asp Leu Leu Ser 
    450                 455                 460                 


Asn Ile Val Met Tyr Ala Pro Leu Val Leu Gln Ser Cys Ser Ser Lys 
465                 470                 475                 480 


Val Thr Glu Ala Phe Asp Tyr Leu Ser Phe Leu Pro Leu Gln Thr Val 
                485                 490                 495     


Gln Arg Leu Leu Lys Ala Val Gln Pro Leu Leu Lys Val Ser Met Ser 
            500                 505                 510         


Met Arg Asp Cys Leu Ile Leu Val Leu Arg Lys Ala Met Phe Ala Asn 
        515                 520                 525             


Gln Leu Asp Ala Arg Lys Ser Ala Val Ala Gly Phe Leu Leu Leu Leu 
    530                 535                 540                 


Lys Asn Phe Lys Val Leu Gly Ser Leu Ser Ser Ser Gln Cys Ser Gln 
545                 550                 555                 560 


Ser Leu Ser Val Ser Gln Val His Val Asp Val His Ser His Tyr Asn 
                565                 570                 575     


Ser Val Ala Asn Glu Thr Phe Cys Leu Glu Ile Met Asp Ser Leu Arg 
            580                 585                 590         


Arg Cys Leu Ser Gln Gln Ala Asp Val Arg Leu Met Leu Tyr Glu Gly 
        595                 600                 605             


Phe Tyr Asp Val Leu Arg Arg Asn Ser Gln Leu Ala Asn Ser Val Met 
    610                 615                 620                 


Gln Thr Leu Leu Ser Gln Leu Lys Gln Phe Tyr Glu Pro Lys Pro Asp 
625                 630                 635                 640 


Leu Leu Pro Pro Leu Lys Leu Glu Ala Cys Ile Leu Thr Gln Gly Asp 
                645                 650                 655     


Lys Ile Ser Leu Gln Glu Pro Leu Asp Tyr Leu Leu Cys Cys Ile Gln 
            660                 665                 670         


His Cys Leu Ala Trp Tyr Lys Asn Thr Val Ile Pro Leu Gln Gln Gly 
        675                 680                 685             


Glu Glu Glu Glu Glu Glu Glu Glu Ala Phe Tyr Glu Asp Leu Asp Asp 
    690                 695                 700                 


Ile Leu Glu Ser Ile Thr Asn Arg Met Ile Lys Ser Glu Leu Glu Asp 
705                 710                 715                 720 


Phe Glu Leu Asp Lys Ser Ala Asp Phe Ser Gln Ser Thr Ser Ile Gly 
                725                 730                 735     


Ile Lys Asn Asn Ile Cys Ala Phe Leu Val Met Gly Val Cys Glu Val 
            740                 745                 750         


Leu Ile Glu Tyr Asn Phe Ser Ile Ser Ser Phe Ser Lys Asn Arg Phe 
        755                 760                 765             


Glu Asp Ile Leu Ser Leu Phe Met Cys Tyr Lys Lys Leu Ser Asp Ile 
    770                 775                 780                 


Leu Asn Glu Lys Ala Gly Lys Ala Lys Thr Lys Met Ala Asn Lys Thr 
785                 790                 795                 800 


Ser Asp Ser Leu Leu Ser Met Lys Phe Val Ser Ser Leu Leu Thr Ala 
                805                 810                 815     


Leu Phe Arg Asp Ser Ile Gln Ser His Gln Glu Ser Leu Ser Val Leu 
            820                 825                 830         


Arg Ser Ser Asn Glu Phe Met Arg Tyr Ala Val Asn Val Ala Leu Gln 
        835                 840                 845             


Lys Val Gln Gln Leu Lys Glu Thr Gly His Val Ser Gly Pro Asp Gly 
    850                 855                 860                 


Gln Asn Pro Glu Lys Ile Phe Gln Asn Leu Cys Asp Ile Thr Arg Val 
865                 870                 875                 880 


Leu Leu Trp Arg Tyr Thr Ser Ile Pro Thr Ser Val Glu Glu Ser Gly 
                885                 890                 895     


Lys Lys Glu Lys Gly Lys Ser Ile Ser Leu Leu Cys Leu Glu Gly Leu 
            900                 905                 910         


Gln Lys Ile Phe Ser Ala Val Gln Gln Phe Tyr Gln Pro Lys Ile Gln 
        915                 920                 925             


Gln Phe Leu Arg Ala Leu Asp Val Thr Asp Lys Glu Gly Glu Glu Arg 
    930                 935                 940                 


Glu Asp Ala Asp Val Ser Val Thr Gln Arg Thr Ala Phe Gln Ile Arg 
945                 950                 955                 960 


Gln Phe Gln Arg Ser Leu Leu Asn Leu Leu Ser Ser Gln Glu Glu Asp 
                965                 970                 975     


Phe Asn Ser Lys Glu Ala Leu Leu Leu Val Thr Val Leu Thr Ser Leu 
            980                 985                 990         


Ser Lys Leu Leu Glu Pro Ser Ser  Pro Gln Phe Val Gln  Met Leu Ser 
        995                 1000                 1005             


Trp Thr  Ser Lys Ile Cys Lys  Glu Asn Ser Arg Glu  Asp Ala Leu 
    1010                 1015                 1020             


Phe Cys  Lys Ser Leu Met Asn  Leu Leu Phe Ser Leu  His Val Ser 
    1025                 1030                 1035             


Tyr Lys  Ser Pro Val Ile Leu  Leu Arg Asp Leu Ser  Gln Asp Ile 
    1040                 1045                 1050             


His Gly  His Leu Gly Asp Ile  Asp Gln Asp Val Glu  Val Glu Lys 
    1055                 1060                 1065             


Thr Asn  His Phe Ala Ile Val  Asn Leu Arg Thr Ala  Ala Pro Thr 
    1070                 1075                 1080             


Val Cys  Leu Leu Val Leu Ser  Gln Ala Glu Lys Val  Leu Glu Glu 
    1085                 1090                 1095             


Val Asp  Trp Leu Ile Thr Lys  Leu Lys Gly Gln Val  Ser Gln Glu 
    1100                 1105                 1110             


Thr Leu  Ser Glu Glu Ala Ser  Ser Gln Ala Thr Leu  Pro Asn Gln 
    1115                 1120                 1125             


Pro Val  Glu Lys Ala Ile Ile  Met Gln Leu Gly Thr  Leu Leu Thr 
    1130                 1135                 1140             


Phe Phe  His Glu Leu Val Gln  Thr Ala Leu Pro Ser  Gly Ser Cys 
    1145                 1150                 1155             


Val Asp  Thr Leu Leu Lys Asp  Leu Cys Lys Met Tyr  Thr Thr Leu 
    1160                 1165                 1170             


Thr Ala  Leu Val Arg Tyr Tyr  Leu Gln Val Cys Gln  Ser Ser Gly 
    1175                 1180                 1185             


Gly Ile  Pro Lys Asn Met Glu  Lys Leu Val Lys Leu  Ser Gly Ser 
    1190                 1195                 1200             


His Leu  Thr Pro Leu Cys Tyr  Ser Phe Ile Ser Tyr  Val Gln Asn 
    1205                 1210                 1215             


Lys Ser  Lys Ser Leu Asn Tyr  Thr Gly Glu Lys Lys  Glu Lys Pro 
    1220                 1225                 1230             


Ala Ala  Val Ala Thr Ala Met  Ala Arg Val Leu Arg  Glu Thr Lys 
    1235                 1240                 1245             


Pro Ile  Pro Asn Leu Ile Phe  Ala Ile Glu Gln Tyr  Glu Lys Phe 
    1250                 1255                 1260             


Leu Ile  His Leu Ser Lys Lys  Ser Lys Val Asn Leu  Met Gln His 
    1265                 1270                 1275             


Met Lys  Leu Ser Thr Ser Arg  Asp Phe Lys Ile Lys  Gly Asn Ile 
    1280                 1285                 1290             


Leu Asp  Met Val Leu Arg Glu  Asp Gly Glu Asp Glu  Asn Glu Glu 
    1295                 1300                 1305             


Gly Thr  Ala Ser Glu His Gly  Gly Gln Asn Lys Glu  Pro Ala Lys 
    1310                 1315                 1320             


Lys Lys  Arg Lys Lys 
    1325             


<210>  3890
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCL__Homo_sapiens__NP_001108108

<400>  3890

Met Ala Val Thr Glu Ala Ser Leu Leu Arg Gln Cys Pro Leu Leu Leu 
1               5                   10                  15      


Pro Gln Asn Arg Ser Lys Thr Val Tyr Glu Gly Phe Ile Ser Ala Gln 
            20                  25                  30          


Gly Arg Asp Phe His Leu Arg Ile Val Leu Pro Glu Asp Leu Gln Leu 
        35                  40                  45              


Lys Asn Ala Arg Leu Leu Cys Ser Trp Gln Leu Arg Thr Ile Leu Ser 
    50                  55                  60                  


Gly Tyr His Arg Ile Val Gln Gln Arg Met Gln His Ser Pro Asp Leu 
65                  70                  75                  80  


Met Ser Phe Met Met Glu Leu Lys Met Leu Leu Glu Val Ala Leu Lys 
                85                  90                  95      


Asn Arg Gln Glu Leu Tyr Ala Leu Pro Pro Pro Pro Gln Phe Tyr Ser 
            100                 105                 110         


Ser Leu Ile Glu Glu Ile Gly Thr Leu Gly Trp Asp Lys Leu Val Tyr 
        115                 120                 125             


Ala Asp Thr Cys Phe Ser Thr Ile Lys Leu Lys Ala Glu Asp Ala Ser 
    130                 135                 140                 


Gly Arg Glu His Leu Ile Thr Leu Lys Leu Lys Ala Lys Tyr Pro Ala 
145                 150                 155                 160 


Glu Ser Pro Asp Tyr Phe Val Asp Phe Pro Val Pro Phe Cys Ala Ser 
                165                 170                 175     


Trp Thr Pro Gln Val Asn Ser Pro Gln Ser Ser Leu Ile Ser Ile Tyr 
            180                 185                 190         


Ser Gln Phe Leu Ala Ala Ile Glu Ser Leu Lys Ala Phe Trp Asp Val 
        195                 200                 205             


Met Asp Glu Ile Asp Glu Lys Thr Trp Val Leu Glu Pro Glu Lys Pro 
    210                 215                 220                 


Pro Arg Ser Ala Thr Ala Arg Arg Ile Ala Leu Gly Asn Asn Val Ser 
225                 230                 235                 240 


Ile Asn Ile Glu Val Asp Pro Arg His Pro Thr Met Leu Pro Glu Cys 
                245                 250                 255     


Phe Phe Leu Gly Ala Asp His Val Val Lys Pro Leu Gly Ile Lys Leu 
            260                 265                 270         


Ser Arg Asn Ile His Leu Trp Asp Pro Glu Asn Ser Val Leu Gln Asn 
        275                 280                 285             


Leu Lys Asp Val Leu Glu Ile Asp Phe Pro Ala Arg Ala Ile Leu Glu 
    290                 295                 300                 


Lys Ser Asp Phe Thr Met Asp Cys Gly Ile Cys Tyr Ala Tyr Gln Leu 
305                 310                 315                 320 


Asp Gly Thr Ile Pro Asp Gln Val Cys Asp Asn Ser Gln Cys Gly Gln 
                325                 330                 335     


Pro Phe His Gln Ile Cys Leu Tyr Glu Trp Leu Arg Gly Leu Leu Thr 
            340                 345                 350         


Ser Arg Gln Ser Phe Asn Ile Ile Phe Gly Glu Cys Pro Tyr Cys Ser 
        355                 360                 365             


Lys Pro Ile Thr Leu Lys Met Ser Gly Arg Lys His 
    370                 375                 380 


<210>  3891
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANCM__Homo_sapiens__NP_065988

<400>  3891

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  3892
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FANK1__Homo_sapiens__NP_660278

<400>  3892

Met Glu Pro Gln Lys Ile Met Pro Pro Ser Lys Pro His Pro Pro Val 
1               5                   10                  15      


Val Gly Lys Val Thr His His Ser Ile Glu Leu Tyr Trp Asp Leu Glu 
            20                  25                  30          


Lys Lys Ala Lys Arg Gln Gly Pro Gln Glu Gln Trp Phe Arg Phe Ser 
        35                  40                  45              


Ile Glu Glu Glu Asp Pro Lys Met His Thr Tyr Gly Ile Ile Tyr Thr 
    50                  55                  60                  


Gly Tyr Ala Thr Lys His Val Val Glu Gly Leu Glu Pro Arg Thr Leu 
65                  70                  75                  80  


Tyr Arg Phe Arg Leu Lys Val Thr Ser Pro Ser Gly Glu Cys Glu Tyr 
                85                  90                  95      


Ser Pro Leu Val Ser Val Ser Thr Thr Arg Glu Pro Ile Ser Ser Glu 
            100                 105                 110         


His Leu His Arg Ala Val Ser Val Asn Asp Glu Asp Leu Leu Val Arg 
        115                 120                 125             


Ile Leu Gln Gly Gly Arg Val Lys Val Asp Val Pro Asn Lys Phe Gly 
    130                 135                 140                 


Phe Thr Ala Leu Met Val Ala Ala Gln Lys Gly Tyr Thr Arg Leu Val 
145                 150                 155                 160 


Lys Ile Leu Val Ser Asn Gly Thr Asp Val Asn Leu Lys Asn Gly Ser 
                165                 170                 175     


Gly Lys Asp Ser Leu Met Leu Ala Cys Tyr Ala Gly His Leu Asp Val 
            180                 185                 190         


Val Lys Tyr Leu Arg Arg His Gly Ala Ser Trp Gln Ala Arg Asp Leu 
        195                 200                 205             


Gly Gly Cys Thr Ala Leu His Trp Ala Ala Asp Gly Gly His Cys Ser 
    210                 215                 220                 


Val Ile Glu Trp Met Ile Lys Asp Gly Cys Glu Val Asp Val Val Asp 
225                 230                 235                 240 


Thr Gly Ser Gly Trp Thr Pro Leu Met Arg Val Ser Ala Val Ser Gly 
                245                 250                 255     


Asn Gln Arg Val Ala Ser Leu Leu Ile Asp Ala Gly Ala Asn Val Asn 
            260                 265                 270         


Val Lys Asp Arg Asn Gly Lys Thr Pro Leu Met Val Ala Val Leu Asn 
        275                 280                 285             


Asn His Glu Glu Leu Val Gln Leu Leu Leu Asp Lys Gly Ala Asp Ala 
    290                 295                 300                 


Ser Val Lys Asn Glu Phe Gly Lys Gly Val Leu Glu Met Ala Arg Val 
305                 310                 315                 320 


Phe Asp Arg Gln Ser Val Val Ser Leu Leu Glu Glu Arg Lys Lys Lys 
                325                 330                 335     


Gln Arg Pro Lys Lys Ser Cys Val Cys 
            340                 345 


<210>  3893
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP__Homo_sapiens__NP_001278736

<400>  3893

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe 
225                 230                 235                 240 


Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro 
                245                 250                 255     


Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr 
    290                 295                 300                 


Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala 
                325                 330                 335     


Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp 
            420                 425                 430         


Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Glu Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu 
545                 550                 555                 560 


Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735 


<210>  3894
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAR1__Homo_sapiens__NP_115604

<400>  3894

Met Val Ser Ile Pro Glu Tyr Tyr Glu Gly Lys Asn Val Leu Leu Thr 
1               5                   10                  15      


Gly Ala Thr Gly Phe Leu Gly Lys Val Leu Leu Glu Lys Leu Leu Arg 
            20                  25                  30          


Ser Cys Pro Lys Val Asn Ser Val Tyr Val Leu Val Arg Gln Lys Ala 
        35                  40                  45              


Gly Gln Thr Pro Gln Glu Arg Val Glu Glu Val Leu Ser Gly Lys Leu 
    50                  55                  60                  


Phe Asp Arg Leu Arg Asp Glu Asn Pro Asp Phe Arg Glu Lys Ile Ile 
65                  70                  75                  80  


Ala Ile Asn Ser Glu Leu Thr Gln Pro Lys Leu Ala Leu Ser Glu Glu 
                85                  90                  95      


Asp Lys Glu Val Ile Ile Asp Ser Thr Asn Ile Ile Phe His Cys Ala 
            100                 105                 110         


Ala Thr Val Arg Phe Asn Glu Asn Leu Arg Asp Ala Val Gln Leu Asn 
        115                 120                 125             


Val Ile Ala Thr Arg Gln Leu Ile Leu Leu Ala Gln Gln Met Lys Asn 
    130                 135                 140                 


Leu Glu Val Phe Met His Val Ser Thr Ala Tyr Ala Tyr Cys Asn Arg 
145                 150                 155                 160 


Lys His Ile Asp Glu Val Val Tyr Pro Pro Pro Val Asp Pro Lys Lys 
                165                 170                 175     


Leu Ile Asp Ser Leu Glu Trp Met Asp Asp Gly Leu Val Asn Asp Ile 
            180                 185                 190         


Thr Pro Lys Leu Ile Gly Asp Arg Pro Asn Thr Tyr Ile Tyr Thr Lys 
        195                 200                 205             


Ala Leu Ala Glu Tyr Val Val Gln Gln Glu Gly Ala Lys Leu Asn Val 
    210                 215                 220                 


Ala Ile Val Arg Pro Ser Ile Val Gly Ala Ser Trp Lys Glu Pro Phe 
225                 230                 235                 240 


Pro Gly Trp Ile Asp Asn Phe Asn Gly Pro Ser Gly Leu Phe Ile Ala 
                245                 250                 255     


Ala Gly Lys Gly Ile Leu Arg Thr Ile Arg Ala Ser Asn Asn Ala Leu 
            260                 265                 270         


Ala Asp Leu Val Pro Val Asp Val Val Val Asn Met Ser Leu Ala Ala 
        275                 280                 285             


Ala Trp Tyr Ser Gly Val Asn Arg Pro Arg Asn Ile Met Val Tyr Asn 
    290                 295                 300                 


Cys Thr Thr Gly Ser Thr Asn Pro Phe His Trp Gly Glu Val Glu Tyr 
305                 310                 315                 320 


His Val Ile Ser Thr Phe Lys Arg Asn Pro Leu Glu Gln Ala Phe Arg 
                325                 330                 335     


Arg Pro Asn Val Asn Leu Thr Ser Asn His Leu Leu Tyr His Tyr Trp 
            340                 345                 350         


Ile Ala Val Ser His Lys Ala Pro Ala Phe Leu Tyr Asp Ile Tyr Leu 
        355                 360                 365             


Arg Met Thr Gly Arg Ser Pro Arg Met Met Lys Thr Ile Thr Arg Leu 
    370                 375                 380                 


His Lys Ala Met Val Phe Leu Glu Tyr Phe Thr Ser Asn Ser Trp Val 
385                 390                 395                 400 


Trp Asn Thr Glu Asn Val Asn Met Leu Met Asn Gln Leu Asn Pro Glu 
                405                 410                 415     


Asp Lys Lys Thr Phe Asn Ile Asp Val Arg Gln Leu His Trp Ala Glu 
            420                 425                 430         


Tyr Ile Glu Asn Tyr Cys Leu Gly Thr Lys Lys Tyr Val Leu Asn Glu 
        435                 440                 445             


Glu Met Ser Gly Leu Pro Ala Ala Arg Lys His Leu Asn Lys Leu Arg 
    450                 455                 460                 


Asn Ile Arg Tyr Gly Phe Asn Thr Ile Leu Val Ile Leu Ile Trp Arg 
465                 470                 475                 480 


Ile Phe Ile Ala Arg Ser Gln Met Ala Arg Asn Ile Trp Tyr Phe Val 
                485                 490                 495     


Val Ser Leu Cys Tyr Lys Phe Leu Ser Tyr Phe Arg Ala Ser Ser Thr 
            500                 505                 510         


Met Arg Tyr 
        515 


<210>  3895
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FARP1__Homo_sapiens__NP_001001715

<400>  3895

Met Gly Glu Ile Glu Gln Arg Pro Thr Pro Gly Ser Arg Leu Gly Ala 
1               5                   10                  15      


Pro Glu Asn Ser Gly Ile Ser Thr Leu Glu Arg Gly Gln Lys Pro Pro 
            20                  25                  30          


Pro Thr Pro Ser Gly Lys Leu Val Ser Ile Lys Ile Gln Met Leu Asp 
        35                  40                  45              


Asp Thr Gln Glu Ala Phe Glu Val Pro Met Val Ser Ser Ser Ser Phe 
    50                  55                  60                  


Leu Lys Ala Thr Gly Ser Ser Trp Thr Gly Trp Val Leu Arg Cys Ser 
65                  70                  75                  80  


Met Lys Pro Lys His His Ser His Leu Ile Glu Lys Phe Gly Glu Asp 
                85                  90                  95      


Arg Ile Leu Thr His Leu Thr Gly Ser Ile Ser Tyr Thr Asn Trp Ala 
            100                 105                 110         


Gly Ser Arg Ser Leu Ala Val Thr Val Thr Glu Glu Leu Leu Asn Leu 
        115                 120                 125             


Phe 
    


<210>  3896
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FARP2__Homo_sapiens__NP_001269912

<400>  3896

Met Gly Glu Ile Glu Gly Thr Tyr Arg Val Leu Gln Thr Ala Gly Met 
1               5                   10                  15      


Arg Leu Gly Ala Gln Thr Pro Val Gly Val Ser Thr Leu Glu Pro Gly 
            20                  25                  30          


Gln Thr Leu Leu Pro Arg Met Gln Glu Lys His Leu His Leu Arg Val 
        35                  40                  45              


Lys Leu Leu Asp Asn Thr Met Glu Ile Phe Asp Ile Glu Pro Lys Cys 
    50                  55                  60                  


Asp Gly Gln Val Leu Leu Thr Gln Val Trp Lys Arg Leu Asn Leu Val 
65                  70                  75                  80  


Glu Cys Asp Tyr Phe Gly Met Glu Phe Gln Asn Thr Gln Ser Tyr Trp 
                85                  90                  95      


Ile Trp Leu Glu Pro Met Lys Pro Ile Ile Arg Gln Ile Arg Arg Pro 
            100                 105                 110         


Lys Asn Val Val Leu Arg Leu Ala Val Lys Phe Phe Pro Pro Asp Pro 
        115                 120                 125             


Gly Gln Leu Gln Glu Glu Tyr Thr Arg Tyr Leu Phe Ala Leu Gln Leu 
    130                 135                 140                 


Lys Arg Asp Leu Leu Glu Glu Arg Leu Thr Cys Ala Asp Thr Thr Ala 
145                 150                 155                 160 


Ala Leu Leu Thr Ser His Leu Leu Gln Ser Glu Ile Gly Asp Tyr Asp 
                165                 170                 175     


Glu Thr Leu Asp Arg Glu His Leu Lys Val Asn Glu Tyr Leu Pro Gly 
            180                 185                 190         


Gln Gln His Cys Leu Glu Lys Ile Leu Glu Phe His Gln Lys His Val 
        195                 200                 205             


Gly Gln Thr Pro Ala Glu Ser Asp Phe Gln Val Leu Glu Ile Ala Arg 
    210                 215                 220                 


Lys Leu Glu Met Tyr Gly Ile Arg Phe His Met Ala Ser Asp Arg Glu 
225                 230                 235                 240 


Gly Thr Lys Ile Gln Leu Ala Val Ser His Met Gly Val Leu Val Phe 
                245                 250                 255     


Gln Gly Thr Thr Lys Ile Asn Thr Phe Asn Trp Ser Lys Val Arg Lys 
            260                 265                 270         


Leu Ser Phe Lys Arg Lys Arg Phe Leu Ile Lys Leu His Pro Glu Val 
        275                 280                 285             


His Gly Pro Tyr Gln Asp Thr Leu Glu Phe Leu Leu Gly Ser Arg Asp 
    290                 295                 300                 


Glu Cys Lys Asn Phe Trp Lys Ile Cys Val Glu Tyr His Thr Phe Phe 
305                 310                 315                 320 


Arg Leu Leu Asp Gln Pro Lys Pro Lys Ala Lys Ala Val Phe Phe Ser 
                325                 330                 335     


Arg Gly Ser Ser Phe Arg Tyr Ser Gly Arg Thr Gln Lys Gln Leu Val 
            340                 345                 350         


Asp Tyr Phe Lys Asp Ser Gly Met Lys Arg Ile Pro Tyr Glu Arg Arg 
        355                 360                 365             


His Ser Lys Thr His Thr Ser Val Arg Ala Leu Thr Ala Asp Leu Pro 
    370                 375                 380                 


Lys Gln Ser Ile Ser Phe Pro Glu Gly Leu Arg Thr Pro Ala Ser Pro 
385                 390                 395                 400 


Ser Ser Ala Asn Ala Phe Tyr Ser Leu Ser Pro Ser Thr Leu Val Pro 
                405                 410                 415     


Ser Gly Leu Pro Glu Phe Lys Asp Ser Ser Ser Ser Leu Thr Asp Pro 
            420                 425                 430         


Gln Val Ser Tyr Val Lys Ser Pro Ala Ala Glu Arg Arg Ser Gly Ala 
        435                 440                 445             


Val Ala Gly Gly Pro Asp Thr Pro Ser Ala Gln Pro Leu Gly Pro Pro 
    450                 455                 460                 


Ala Leu Gln Pro Gly Pro Gly Leu Ser Thr Lys Ser Pro Gln Pro Ser 
465                 470                 475                 480 


Pro Ser Ser Arg Lys Ser Pro Leu Ser Leu Ser Pro Ala Phe Gln Val 
                485                 490                 495     


Pro Leu Gly Pro Ala Glu Gln Gly Ser Ser Pro Leu Leu Ser Pro Val 
            500                 505                 510         


Leu Ser Asp Ala Gly Gly Ala Gly Met Asp Cys Glu Glu Pro Arg His 
        515                 520                 525             


Lys Arg Val Pro Ala Asp Glu Ala Tyr Phe Ile Val Lys Glu Ile Leu 
    530                 535                 540                 


Ala Thr Glu Arg Thr Tyr Leu Lys Asp Leu Glu Val Ile Thr Val Trp 
545                 550                 555                 560 


Phe Arg Ser Ala Val Val Lys Glu Asp Ala Met Pro Ala Thr Leu Met 
                565                 570                 575     


Thr Leu Leu Phe Ser Asn Ile Asp Pro Ile Tyr Glu Phe His Arg Gly 
            580                 585                 590         


Phe Leu Arg Glu Val Glu Gln Arg Leu Ala Leu Trp Glu Gly Pro Ser 
        595                 600                 605             


Lys Ala His Thr Lys Gly Ser His Gln Arg Ile Gly Asp Ile Leu Leu 
    610                 615                 620                 


Arg Asn Met Arg Gln Leu Lys Val Phe Gln Leu His Glu Gly His Val 
625                 630                 635                 640 


Ala Gly Val Thr Lys Met Glu 
                645         


<210>  3897
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FARS2__Homo_sapiens__NP_001305801

<400>  3897

Met Val Gly Ser Ala Leu Arg Arg Gly Ala His Ala Tyr Val Tyr Leu 
1               5                   10                  15      


Val Ser Lys Ala Ser His Ile Ser Arg Gly His Gln His Gln Ala Trp 
            20                  25                  30          


Gly Ser Arg Pro Pro Ala Ala Glu Cys Ala Thr Gln Arg Ala Pro Gly 
        35                  40                  45              


Ser Val Val Glu Leu Leu Gly Lys Ser Tyr Pro Gln Asp Asp His Ser 
    50                  55                  60                  


Asn Leu Thr Arg Lys Val Leu Thr Arg Val Gly Arg Asn Leu His Asn 
65                  70                  75                  80  


Gln Gln His His Pro Leu Trp Leu Ile Lys Glu Arg Val Lys Glu His 
                85                  90                  95      


Phe Tyr Lys Gln Tyr Val Gly Arg Phe Gly Thr Pro Leu Phe Ser Val 
            100                 105                 110         


Tyr Asp Asn Leu Ser Pro Val Val Thr Thr Trp Gln Asn Phe Asp Ser 
        115                 120                 125             


Leu Leu Ile Pro Ala Asp His Pro Ser Arg Lys Lys Gly Asp Asn Tyr 
    130                 135                 140                 


Tyr Leu Asn Arg Thr His Met Leu Arg Ala His Thr Ser Ala His Gln 
145                 150                 155                 160 


Trp Asp Leu Leu His Ala Gly Leu Asp Ala Phe Leu Val Val Gly Asp 
                165                 170                 175     


Val Tyr Arg Arg Asp Gln Ile Asp Ser Gln His Tyr Pro Ile Phe His 
            180                 185                 190         


Gln Leu Glu Ala Val Arg Leu Phe Ser Lys His Glu Leu Phe Ala Gly 
        195                 200                 205             


Ile Lys Asp Gly Glu Ser Leu Gln Leu Phe Glu Gln Ser Ser Arg Ser 
    210                 215                 220                 


Ala His Lys Gln Glu Thr His Thr Met Glu Ala Val Lys Leu Val Glu 
225                 230                 235                 240 


Phe Asp Leu Lys Gln Thr Leu Thr Arg Leu Met Ala His Leu Phe Gly 
                245                 250                 255     


Asp Glu Leu Glu Ile Arg Trp Val Asp Cys Tyr Phe Pro Phe Thr His 
            260                 265                 270         


Pro Ser Phe Glu Met Glu Ile Asn Phe His Gly Glu Trp Leu Glu Val 
        275                 280                 285             


Leu Gly Cys Gly Val Met Glu Gln Gln Leu Val Asn Ser Ala Gly Ala 
    290                 295                 300                 


Gln Asp Arg Ile Gly Trp Ala Phe Gly Leu Gly Leu Glu Arg Leu Ala 
305                 310                 315                 320 


Met Ile Leu Tyr Asp Ile Pro Asp Ile Arg Leu Phe Trp Cys Glu Asp 
                325                 330                 335     


Glu Arg Phe Leu Lys Gln Phe Cys Val Ser Asn Ile Asn Gln Lys Val 
            340                 345                 350         


Lys Phe Gln Pro Leu Ser Lys Tyr Pro Ala Val Ile Asn Asp Ile Ser 
        355                 360                 365             


Phe Trp Leu Pro Ser Glu Asn Tyr Ala Glu Asn Asp Phe Tyr Asp Leu 
    370                 375                 380                 


Val Arg Thr Ile Gly Gly Asp Leu Val Glu Lys Val Asp Leu Ile Asp 
385                 390                 395                 400 


Lys Phe Val His Pro Lys Thr His Lys Thr Ser His Cys Tyr Arg Ile 
                405                 410                 415     


Thr Tyr Arg His Met Glu Arg Thr Leu Ser Gln Arg Glu Val Arg His 
            420                 425                 430         


Ile His Gln Ala Leu Gln Glu Ala Ala Val Gln Leu Leu Gly Val Glu 
        435                 440                 445             


Gly Arg Phe 
    450     


<210>  3898
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FARSA__Homo_sapiens__NP_004452

<400>  3898

Met Ala Asp Gly Gln Val Ala Glu Leu Leu Leu Arg Arg Leu Glu Ala 
1               5                   10                  15      


Ser Asp Gly Gly Leu Asp Ser Ala Glu Leu Ala Ala Glu Leu Gly Met 
            20                  25                  30          


Glu His Gln Ala Val Val Gly Ala Val Lys Ser Leu Gln Ala Leu Gly 
        35                  40                  45              


Glu Val Ile Glu Ala Glu Leu Arg Ser Thr Lys His Trp Glu Leu Thr 
    50                  55                  60                  


Ala Glu Gly Glu Glu Ile Ala Arg Glu Gly Ser His Glu Ala Arg Val 
65                  70                  75                  80  


Phe Arg Ser Ile Pro Pro Glu Gly Leu Ala Gln Ser Glu Leu Met Arg 
                85                  90                  95      


Leu Pro Ser Gly Lys Val Gly Phe Ser Lys Ala Met Ser Asn Lys Trp 
            100                 105                 110         


Ile Arg Val Asp Lys Ser Ala Ala Asp Gly Pro Arg Val Phe Arg Val 
        115                 120                 125             


Val Asp Ser Met Glu Asp Glu Val Gln Arg Arg Leu Gln Leu Val Arg 
    130                 135                 140                 


Gly Gly Gln Ala Glu Lys Leu Gly Glu Lys Glu Arg Ser Glu Leu Arg 
145                 150                 155                 160 


Lys Arg Lys Leu Leu Ala Glu Val Thr Leu Lys Thr Tyr Trp Val Ser 
                165                 170                 175     


Lys Gly Ser Ala Phe Ser Thr Ser Ile Ser Lys Gln Glu Thr Glu Leu 
            180                 185                 190         


Ser Pro Glu Met Ile Ser Ser Gly Ser Trp Arg Asp Arg Pro Phe Lys 
        195                 200                 205             


Pro Tyr Asn Phe Leu Ala His Gly Val Leu Pro Asp Ser Gly His Leu 
    210                 215                 220                 


His Pro Leu Leu Lys Val Arg Ser Gln Phe Arg Gln Ile Phe Leu Glu 
225                 230                 235                 240 


Met Gly Phe Thr Glu Met Pro Thr Asp Asn Phe Ile Glu Ser Ser Phe 
                245                 250                 255     


Trp Asn Phe Asp Ala Leu Phe Gln Pro Gln Gln His Pro Ala Arg Asp 
            260                 265                 270         


Gln His Asp Thr Phe Phe Leu Arg Asp Pro Ala Glu Ala Leu Gln Leu 
        275                 280                 285             


Pro Met Asp Tyr Val Gln Arg Val Lys Arg Thr His Ser Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Tyr Lys Tyr Asn Trp Lys Leu Asp Glu Ala Arg 
305                 310                 315                 320 


Lys Asn Leu Leu Arg Thr His Thr Thr Ser Ala Ser Ala Arg Ala Leu 
                325                 330                 335     


Tyr Arg Leu Ala Gln Lys Lys Pro Phe Thr Pro Val Lys Tyr Phe Ser 
            340                 345                 350         


Ile Asp Arg Val Phe Arg Asn Glu Thr Leu Asp Ala Thr His Leu Ala 
        355                 360                 365             


Glu Phe His Gln Ile Glu Gly Val Val Ala Asp His Gly Leu Thr Leu 
    370                 375                 380                 


Gly His Leu Met Gly Val Leu Arg Glu Phe Phe Thr Lys Leu Gly Ile 
385                 390                 395                 400 


Thr Gln Leu Arg Phe Lys Pro Ala Tyr Asn Pro Tyr Thr Glu Pro Ser 
                405                 410                 415     


Met Glu Val Phe Ser Tyr His Gln Gly Leu Lys Lys Trp Val Glu Val 
            420                 425                 430         


Gly Asn Ser Gly Val Phe Arg Pro Glu Met Leu Leu Pro Met Gly Leu 
        435                 440                 445             


Pro Glu Asn Val Ser Val Ile Ala Trp Gly Leu Ser Leu Glu Arg Pro 
    450                 455                 460                 


Thr Met Ile Lys Tyr Gly Ile Asn Asn Ile Arg Glu Leu Val Gly His 
465                 470                 475                 480 


Lys Val Asn Leu Gln Met Val Tyr Asp Ser Pro Leu Cys Arg Leu Asp 
                485                 490                 495     


Ala Glu Pro Arg Pro Pro Pro Thr Gln Glu Ala Ala 
            500                 505             


<210>  3899
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAS__Homo_sapiens__NP_000034

<400>  3899

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  3900
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FASLG__Homo_sapiens__NP_000630

<400>  3900

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  3901
<211>  2511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FASN__Homo_sapiens__NP_004095

<400>  3901

Met Glu Glu Val Val Ile Ala Gly Met Ser Gly Lys Leu Pro Glu Ser 
1               5                   10                  15      


Glu Asn Leu Gln Glu Phe Trp Asp Asn Leu Ile Gly Gly Val Asp Met 
            20                  25                  30          


Val Thr Asp Asp Asp Arg Arg Trp Lys Ala Gly Leu Tyr Gly Leu Pro 
        35                  40                  45              


Arg Arg Ser Gly Lys Leu Lys Asp Leu Ser Arg Phe Asp Ala Ser Phe 
    50                  55                  60                  


Phe Gly Val His Pro Lys Gln Ala His Thr Met Asp Pro Gln Leu Arg 
65                  70                  75                  80  


Leu Leu Leu Glu Val Thr Tyr Glu Ala Ile Val Asp Gly Gly Ile Asn 
                85                  90                  95      


Pro Asp Ser Leu Arg Gly Thr His Thr Gly Val Trp Val Gly Val Ser 
            100                 105                 110         


Gly Ser Glu Thr Ser Glu Ala Leu Ser Arg Asp Pro Glu Thr Leu Val 
        115                 120                 125             


Gly Tyr Ser Met Val Gly Cys Gln Arg Ala Met Met Ala Asn Arg Leu 
    130                 135                 140                 


Ser Phe Phe Phe Asp Phe Arg Gly Pro Ser Ile Ala Leu Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Met Ala Leu Gln Asn Ala Tyr Gln Ala Ile His 
                165                 170                 175     


Ser Gly Gln Cys Pro Ala Ala Ile Val Gly Gly Ile Asn Val Leu Leu 
            180                 185                 190         


Lys Pro Asn Thr Ser Val Gln Phe Leu Arg Leu Gly Met Leu Ser Pro 
        195                 200                 205             


Glu Gly Thr Cys Lys Ala Phe Asp Thr Ala Gly Asn Gly Tyr Cys Arg 
    210                 215                 220                 


Ser Glu Gly Val Val Ala Val Leu Leu Thr Lys Lys Ser Leu Ala Arg 
225                 230                 235                 240 


Arg Val Tyr Ala Thr Ile Leu Asn Ala Gly Thr Asn Thr Asp Gly Phe 
                245                 250                 255     


Lys Glu Gln Gly Val Thr Phe Pro Ser Gly Asp Ile Gln Glu Gln Leu 
            260                 265                 270         


Ile Arg Ser Leu Tyr Gln Ser Ala Gly Val Ala Pro Glu Ser Phe Glu 
        275                 280                 285             


Tyr Ile Glu Ala His Gly Thr Gly Thr Lys Val Gly Asp Pro Gln Glu 
    290                 295                 300                 


Leu Asn Gly Ile Thr Arg Ala Leu Cys Ala Thr Arg Gln Glu Pro Leu 
305                 310                 315                 320 


Leu Ile Gly Ser Thr Lys Ser Asn Met Gly His Pro Glu Pro Ala Ser 
                325                 330                 335     


Gly Leu Ala Ala Leu Ala Lys Val Leu Leu Ser Leu Glu His Gly Leu 
            340                 345                 350         


Trp Ala Pro Asn Leu His Phe His Ser Pro Asn Pro Glu Ile Pro Ala 
        355                 360                 365             


Leu Leu Asp Gly Arg Leu Gln Val Val Asp Gln Pro Leu Pro Val Arg 
    370                 375                 380                 


Gly Gly Asn Val Gly Ile Asn Ser Phe Gly Phe Gly Gly Ser Asn Val 
385                 390                 395                 400 


His Ile Ile Leu Arg Pro Asn Thr Gln Pro Pro Pro Ala Pro Ala Pro 
                405                 410                 415     


His Ala Thr Leu Pro Arg Leu Leu Arg Ala Ser Gly Arg Thr Pro Glu 
            420                 425                 430         


Ala Val Gln Lys Leu Leu Glu Gln Gly Leu Arg His Ser Gln Asp Leu 
        435                 440                 445             


Ala Phe Leu Ser Met Leu Asn Asp Ile Ala Ala Val Pro Ala Thr Ala 
    450                 455                 460                 


Met Pro Phe Arg Gly Tyr Ala Val Leu Gly Gly Glu Arg Gly Gly Pro 
465                 470                 475                 480 


Glu Val Gln Gln Val Pro Ala Gly Glu Arg Pro Leu Trp Phe Ile Cys 
                485                 490                 495     


Ser Gly Met Gly Thr Gln Trp Arg Gly Met Gly Leu Ser Leu Met Arg 
            500                 505                 510         


Leu Asp Arg Phe Arg Asp Ser Ile Leu Arg Ser Asp Glu Ala Val Lys 
        515                 520                 525             


Pro Phe Gly Leu Lys Val Ser Gln Leu Leu Leu Ser Thr Asp Glu Ser 
    530                 535                 540                 


Thr Phe Asp Asp Ile Val His Ser Phe Val Ser Leu Thr Ala Ile Gln 
545                 550                 555                 560 


Ile Gly Leu Ile Asp Leu Leu Ser Cys Met Gly Leu Arg Pro Asp Gly 
                565                 570                 575     


Ile Val Gly His Ser Leu Gly Glu Val Ala Cys Gly Tyr Ala Asp Gly 
            580                 585                 590         


Cys Leu Ser Gln Glu Glu Ala Val Leu Ala Ala Tyr Trp Arg Gly Gln 
        595                 600                 605             


Cys Ile Lys Glu Ala His Leu Pro Pro Gly Ala Met Ala Ala Val Gly 
    610                 615                 620                 


Leu Ser Trp Glu Glu Cys Lys Gln Arg Cys Pro Pro Gly Val Val Pro 
625                 630                 635                 640 


Ala Cys His Asn Ser Lys Asp Thr Val Thr Ile Ser Gly Pro Gln Ala 
                645                 650                 655     


Pro Val Phe Glu Phe Val Glu Gln Leu Arg Lys Glu Gly Val Phe Ala 
            660                 665                 670         


Lys Glu Val Arg Thr Gly Gly Met Ala Phe His Ser Tyr Phe Met Glu 
        675                 680                 685             


Ala Ile Ala Pro Pro Leu Leu Gln Glu Leu Lys Lys Val Ile Arg Glu 
    690                 695                 700                 


Pro Lys Pro Arg Ser Ala Arg Trp Leu Ser Thr Ser Ile Pro Glu Ala 
705                 710                 715                 720 


Gln Trp His Ser Ser Leu Ala Arg Thr Ser Ser Ala Glu Tyr Asn Val 
                725                 730                 735     


Asn Asn Leu Val Ser Pro Val Leu Phe Gln Glu Ala Leu Trp His Val 
            740                 745                 750         


Pro Glu His Ala Val Val Leu Glu Ile Ala Pro His Ala Leu Leu Gln 
        755                 760                 765             


Ala Val Leu Lys Arg Gly Leu Lys Pro Ser Cys Thr Ile Ile Pro Leu 
    770                 775                 780                 


Met Lys Lys Asp His Arg Asp Asn Leu Glu Phe Phe Leu Ala Gly Ile 
785                 790                 795                 800 


Gly Arg Leu His Leu Ser Gly Ile Asp Ala Asn Pro Asn Ala Leu Phe 
                805                 810                 815     


Pro Pro Val Glu Phe Pro Ala Pro Arg Gly Thr Pro Leu Ile Ser Pro 
            820                 825                 830         


Leu Ile Lys Trp Asp His Ser Leu Ala Trp Asp Val Pro Ala Ala Glu 
        835                 840                 845             


Asp Phe Pro Asn Gly Ser Gly Ser Pro Ser Ala Ala Ile Tyr Asn Ile 
    850                 855                 860                 


Asp Thr Ser Ser Glu Ser Pro Asp His Tyr Leu Val Asp His Thr Leu 
865                 870                 875                 880 


Asp Gly Arg Val Leu Phe Pro Ala Thr Gly Tyr Leu Ser Ile Val Trp 
                885                 890                 895     


Lys Thr Leu Ala Arg Ala Leu Gly Leu Gly Val Glu Gln Leu Pro Val 
            900                 905                 910         


Val Phe Glu Asp Val Val Leu His Gln Ala Thr Ile Leu Pro Lys Thr 
        915                 920                 925             


Gly Thr Val Ser Leu Glu Val Arg Leu Leu Glu Ala Ser Arg Ala Phe 
    930                 935                 940                 


Glu Val Ser Glu Asn Gly Asn Leu Val Val Ser Gly Lys Val Tyr Gln 
945                 950                 955                 960 


Trp Asp Asp Pro Asp Pro Arg Leu Phe Asp His Pro Glu Ser Pro Thr 
                965                 970                 975     


Pro Asn Pro Thr Glu Pro Leu Phe Leu Ala Gln Ala Glu Val Tyr Lys 
            980                 985                 990         


Glu Leu Arg Leu Arg Gly Tyr Asp  Tyr Gly Pro His Phe  Gln Gly Ile 
        995                 1000                 1005             


Leu Glu  Ala Ser Leu Glu Gly  Asp Ser Gly Arg Leu  Leu Trp Lys 
    1010                 1015                 1020             


Asp Asn  Trp Val Ser Phe Met  Asp Thr Met Leu Gln  Met Ser Ile 
    1025                 1030                 1035             


Leu Gly  Ser Ala Lys His Gly  Leu Tyr Leu Pro Thr  Arg Val Thr 
    1040                 1045                 1050             


Ala Ile  His Ile Asp Pro Ala  Thr His Arg Gln Lys  Leu Tyr Thr 
    1055                 1060                 1065             


Leu Gln  Asp Lys Ala Gln Val  Ala Asp Val Val Val  Ser Arg Trp 
    1070                 1075                 1080             


Leu Arg  Val Thr Val Ala Gly  Gly Val His Ile Ser  Gly Leu His 
    1085                 1090                 1095             


Thr Glu  Ser Ala Pro Arg Arg  Gln Gln Glu Gln Gln  Val Pro Ile 
    1100                 1105                 1110             


Leu Glu  Lys Phe Cys Phe Thr  Pro His Thr Glu Glu  Gly Cys Leu 
    1115                 1120                 1125             


Ser Glu  Arg Ala Ala Leu Gln  Glu Glu Leu Gln Leu  Cys Lys Gly 
    1130                 1135                 1140             


Leu Val  Gln Ala Leu Gln Thr  Lys Val Thr Gln Gln  Gly Leu Lys 
    1145                 1150                 1155             


Met Val  Val Pro Gly Leu Asp  Gly Ala Gln Ile Pro  Arg Asp Pro 
    1160                 1165                 1170             


Ser Gln  Gln Glu Leu Pro Arg  Leu Leu Ser Ala Ala  Cys Arg Leu 
    1175                 1180                 1185             


Gln Leu  Asn Gly Asn Leu Gln  Leu Glu Leu Ala Gln  Val Leu Ala 
    1190                 1195                 1200             


Gln Glu  Arg Pro Lys Leu Pro  Glu Asp Pro Leu Leu  Ser Gly Leu 
    1205                 1210                 1215             


Leu Asp  Ser Pro Ala Leu Lys  Ala Cys Leu Asp Thr  Ala Val Glu 
    1220                 1225                 1230             


Asn Met  Pro Ser Leu Lys Met  Lys Val Val Glu Val  Leu Ala Gly 
    1235                 1240                 1245             


His Gly  His Leu Tyr Ser Arg  Ile Pro Gly Leu Leu  Ser Pro His 
    1250                 1255                 1260             


Pro Leu  Leu Gln Leu Ser Tyr  Thr Ala Thr Asp Arg  His Pro Gln 
    1265                 1270                 1275             


Ala Leu  Glu Ala Ala Gln Ala  Glu Leu Gln Gln His  Asp Val Ala 
    1280                 1285                 1290             


Gln Gly  Gln Trp Asp Pro Ala  Asp Pro Ala Pro Ser  Ala Leu Gly 
    1295                 1300                 1305             


Ser Ala  Asp Leu Leu Val Cys  Asn Cys Ala Val Ala  Ala Leu Gly 
    1310                 1315                 1320             


Asp Pro  Ala Ser Ala Leu Ser  Asn Met Val Ala Ala  Leu Arg Glu 
    1325                 1330                 1335             


Gly Gly  Phe Leu Leu Leu His  Thr Leu Leu Arg Gly  His Pro Leu 
    1340                 1345                 1350             


Gly Asp  Ile Val Ala Phe Leu  Thr Ser Thr Glu Pro  Gln Tyr Gly 
    1355                 1360                 1365             


Gln Gly  Ile Leu Ser Gln Asp  Ala Trp Glu Ser Leu  Phe Ser Arg 
    1370                 1375                 1380             


Val Ser  Leu Arg Leu Val Gly  Leu Lys Lys Ser Phe  Tyr Gly Ser 
    1385                 1390                 1395             


Thr Leu  Phe Leu Cys Arg Arg  Pro Thr Pro Gln Asp  Ser Pro Ile 
    1400                 1405                 1410             


Phe Leu  Pro Val Asp Asp Thr  Ser Phe Arg Trp Val  Glu Ser Leu 
    1415                 1420                 1425             


Lys Gly  Ile Leu Ala Asp Glu  Asp Ser Ser Arg Pro  Val Trp Leu 
    1430                 1435                 1440             


Lys Ala  Ile Asn Cys Ala Thr  Ser Gly Val Val Gly  Leu Val Asn 
    1445                 1450                 1455             


Cys Leu  Arg Arg Glu Pro Gly  Gly Asn Arg Leu Arg  Cys Val Leu 
    1460                 1465                 1470             


Leu Ser  Asn Leu Ser Ser Thr  Ser His Val Pro Glu  Val Asp Pro 
    1475                 1480                 1485             


Gly Ser  Ala Glu Leu Gln Lys  Val Leu Gln Gly Asp  Leu Val Met 
    1490                 1495                 1500             


Asn Val  Tyr Arg Asp Gly Ala  Trp Gly Ala Phe Arg  His Phe Leu 
    1505                 1510                 1515             


Leu Glu  Glu Asp Lys Pro Glu  Glu Pro Thr Ala His  Ala Phe Val 
    1520                 1525                 1530             


Ser Thr  Leu Thr Arg Gly Asp  Leu Ser Ser Ile Arg  Trp Val Cys 
    1535                 1540                 1545             


Ser Ser  Leu Arg His Ala Gln  Pro Thr Cys Pro Gly  Ala Gln Leu 
    1550                 1555                 1560             


Cys Thr  Val Tyr Tyr Ala Ser  Leu Asn Phe Arg Asp  Ile Met Leu 
    1565                 1570                 1575             


Ala Thr  Gly Lys Leu Ser Pro  Asp Ala Ile Pro Gly  Lys Trp Thr 
    1580                 1585                 1590             


Ser Gln  Asp Ser Leu Leu Gly  Met Glu Phe Ser Gly  Arg Asp Ala 
    1595                 1600                 1605             


Ser Gly  Lys Arg Val Met Gly  Leu Val Pro Ala Lys  Gly Leu Ala 
    1610                 1615                 1620             


Thr Ser  Val Leu Leu Ser Pro  Asp Phe Leu Trp Asp  Val Pro Ser 
    1625                 1630                 1635             


Asn Trp  Thr Leu Glu Glu Ala  Ala Ser Val Pro Val  Val Tyr Ser 
    1640                 1645                 1650             


Thr Ala  Tyr Tyr Ala Leu Val  Val Arg Gly Arg Val  Arg Pro Gly 
    1655                 1660                 1665             


Glu Thr  Leu Leu Ile His Ser  Gly Ser Gly Gly Val  Gly Gln Ala 
    1670                 1675                 1680             


Ala Ile  Ala Ile Ala Leu Ser  Leu Gly Cys Arg Val  Phe Thr Thr 
    1685                 1690                 1695             


Val Gly  Ser Ala Glu Lys Arg  Ala Tyr Leu Gln Ala  Arg Phe Pro 
    1700                 1705                 1710             


Gln Leu  Asp Ser Thr Ser Phe  Ala Asn Ser Arg Asp  Thr Ser Phe 
    1715                 1720                 1725             


Glu Gln  His Val Leu Trp His  Thr Gly Gly Lys Gly  Val Asp Leu 
    1730                 1735                 1740             


Val Leu  Asn Ser Leu Ala Glu  Glu Lys Leu Gln Ala  Ser Val Arg 
    1745                 1750                 1755             


Cys Leu  Ala Thr His Gly Arg  Phe Leu Glu Ile Gly  Lys Phe Asp 
    1760                 1765                 1770             


Leu Ser  Gln Asn His Pro Leu  Gly Met Ala Ile Phe  Leu Lys Asn 
    1775                 1780                 1785             


Val Thr  Phe His Gly Val Leu  Leu Asp Ala Phe Phe  Asn Glu Ser 
    1790                 1795                 1800             


Ser Ala  Asp Trp Arg Glu Val  Trp Ala Leu Val Gln  Ala Gly Ile 
    1805                 1810                 1815             


Arg Asp  Gly Val Val Arg Pro  Leu Lys Cys Thr Val  Phe His Gly 
    1820                 1825                 1830             


Ala Gln  Val Glu Asp Ala Phe  Arg Tyr Met Ala Gln  Gly Lys His 
    1835                 1840                 1845             


Ile Gly  Lys Val Val Val Gln  Val Leu Ala Glu Glu  Pro Glu Ala 
    1850                 1855                 1860             


Val Leu  Lys Gly Ala Lys Pro  Lys Leu Met Ser Ala  Ile Ser Lys 
    1865                 1870                 1875             


Thr Phe  Cys Pro Ala His Lys  Ser Tyr Ile Ile Ala  Gly Gly Leu 
    1880                 1885                 1890             


Gly Gly  Phe Gly Leu Glu Leu  Ala Gln Trp Leu Ile  Gln Arg Gly 
    1895                 1900                 1905             


Val Gln  Lys Leu Val Leu Thr  Ser Arg Ser Gly Ile  Arg Thr Gly 
    1910                 1915                 1920             


Tyr Gln  Ala Lys Gln Val Arg  Arg Trp Arg Arg Gln  Gly Val Gln 
    1925                 1930                 1935             


Val Gln  Val Ser Thr Ser Asn  Ile Ser Ser Leu Glu  Gly Ala Arg 
    1940                 1945                 1950             


Gly Leu  Ile Ala Glu Ala Ala  Gln Leu Gly Pro Val  Gly Gly Val 
    1955                 1960                 1965             


Phe Asn  Leu Ala Val Val Leu  Arg Asp Gly Leu Leu  Glu Asn Gln 
    1970                 1975                 1980             


Thr Pro  Glu Phe Phe Gln Asp  Val Cys Lys Pro Lys  Tyr Ser Gly 
    1985                 1990                 1995             


Thr Leu  Asn Leu Asp Arg Val  Thr Arg Glu Ala Cys  Pro Glu Leu 
    2000                 2005                 2010             


Asp Tyr  Phe Val Val Phe Ser  Ser Val Ser Cys Gly  Arg Gly Asn 
    2015                 2020                 2025             


Ala Gly  Gln Ser Asn Tyr Gly  Phe Ala Asn Ser Ala  Met Glu Arg 
    2030                 2035                 2040             


Ile Cys  Glu Lys Arg Arg His  Glu Gly Leu Pro Gly  Leu Ala Val 
    2045                 2050                 2055             


Gln Trp  Gly Ala Ile Gly Asp  Val Gly Ile Leu Val  Glu Thr Met 
    2060                 2065                 2070             


Ser Thr  Asn Asp Thr Ile Val  Ser Gly Thr Leu Pro  Gln Arg Met 
    2075                 2080                 2085             


Ala Ser  Cys Leu Glu Val Leu  Asp Leu Phe Leu Asn  Gln Pro His 
    2090                 2095                 2100             


Met Val  Leu Ser Ser Phe Val  Leu Ala Glu Lys Ala  Ala Ala Tyr 
    2105                 2110                 2115             


Arg Asp  Arg Asp Ser Gln Arg  Asp Leu Val Glu Ala  Val Ala His 
    2120                 2125                 2130             


Ile Leu  Gly Ile Arg Asp Leu  Ala Ala Val Asn Leu  Asp Ser Ser 
    2135                 2140                 2145             


Leu Ala  Asp Leu Gly Leu Asp  Ser Leu Met Ser Val  Glu Val Arg 
    2150                 2155                 2160             


Gln Thr  Leu Glu Arg Glu Leu  Asn Leu Val Leu Ser  Val Arg Glu 
    2165                 2170                 2175             


Val Arg  Gln Leu Thr Leu Arg  Lys Leu Gln Glu Leu  Ser Ser Lys 
    2180                 2185                 2190             


Ala Asp  Glu Ala Ser Glu Leu  Ala Cys Pro Thr Pro  Lys Glu Asp 
    2195                 2200                 2205             


Gly Leu  Ala Gln Gln Gln Thr  Gln Leu Asn Leu Arg  Ser Leu Leu 
    2210                 2215                 2220             


Val Asn  Pro Glu Gly Pro Thr  Leu Met Arg Leu Asn  Ser Val Gln 
    2225                 2230                 2235             


Ser Ser  Glu Arg Pro Leu Phe  Leu Val His Pro Ile  Glu Gly Ser 
    2240                 2245                 2250             


Thr Thr  Val Phe His Ser Leu  Ala Ser Arg Leu Ser  Ile Pro Thr 
    2255                 2260                 2265             


Tyr Gly  Leu Gln Cys Thr Arg  Ala Ala Pro Leu Asp  Ser Ile His 
    2270                 2275                 2280             


Ser Leu  Ala Ala Tyr Tyr Ile  Asp Cys Ile Arg Gln  Val Gln Pro 
    2285                 2290                 2295             


Glu Gly  Pro Tyr Arg Val Ala  Gly Tyr Ser Tyr Gly  Ala Cys Val 
    2300                 2305                 2310             


Ala Phe  Glu Met Cys Ser Gln  Leu Gln Ala Gln Gln  Ser Pro Ala 
    2315                 2320                 2325             


Pro Thr  His Asn Ser Leu Phe  Leu Phe Asp Gly Ser  Pro Thr Tyr 
    2330                 2335                 2340             


Val Leu  Ala Tyr Thr Gln Ser  Tyr Arg Ala Lys Leu  Thr Pro Gly 
    2345                 2350                 2355             


Cys Glu  Ala Glu Ala Glu Thr  Glu Ala Ile Cys Phe  Phe Val Gln 
    2360                 2365                 2370             


Gln Phe  Thr Asp Met Glu His  Asn Arg Val Leu Glu  Ala Leu Leu 
    2375                 2380                 2385             


Pro Leu  Lys Gly Leu Glu Glu  Arg Val Ala Ala Ala  Val Asp Leu 
    2390                 2395                 2400             


Ile Ile  Lys Ser His Gln Gly  Leu Asp Arg Gln Glu  Leu Ser Phe 
    2405                 2410                 2415             


Ala Ala  Arg Ser Phe Tyr Tyr  Lys Leu Arg Ala Ala  Glu Gln Tyr 
    2420                 2425                 2430             


Thr Pro  Lys Ala Lys Tyr His  Gly Asn Val Met Leu  Leu Arg Ala 
    2435                 2440                 2445             


Lys Thr  Gly Gly Ala Tyr Gly  Glu Asp Leu Gly Ala  Asp Tyr Asn 
    2450                 2455                 2460             


Leu Ser  Gln Val Cys Asp Gly  Lys Val Ser Val His  Val Ile Glu 
    2465                 2470                 2475             


Gly Asp  His Arg Thr Leu Leu  Glu Gly Ser Gly Leu  Glu Ser Ile 
    2480                 2485                 2490             


Ile Ser  Ile Ile His Ser Ser  Leu Ala Glu Pro Arg  Val Ser Val 
    2495                 2500                 2505             


Arg Glu  Gly 
    2510     


<210>  3902
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FASTKD2__Homo_sapiens__NP_055744

<400>  3902

Met Leu Thr Thr Leu Lys Pro Phe Gly Ser Val Ser Val Glu Ser Lys 
1               5                   10                  15      


Met Asn Asn Lys Ala Gly Ser Phe Phe Trp Asn Leu Arg Gln Phe Ser 
            20                  25                  30          


Thr Leu Val Ser Thr Ser Arg Thr Met Arg Leu Cys Cys Leu Gly Leu 
        35                  40                  45              


Cys Lys Pro Lys Ile Val His Ser Asn Trp Asn Ile Leu Asn Asn Phe 
    50                  55                  60                  


His Asn Arg Met Gln Ser Thr Asp Ile Ile Arg Tyr Leu Phe Gln Asp 
65                  70                  75                  80  


Ala Phe Ile Phe Lys Ser Asp Val Gly Phe Gln Thr Lys Gly Ile Ser 
                85                  90                  95      


Thr Leu Thr Ala Leu Arg Ile Glu Arg Leu Leu Tyr Ala Lys Arg Leu 
            100                 105                 110         


Phe Phe Asp Ser Lys Gln Ser Leu Val Pro Val Asp Lys Ser Asp Asp 
        115                 120                 125             


Glu Leu Lys Lys Val Asn Leu Asn His Glu Val Ser Asn Glu Asp Val 
    130                 135                 140                 


Leu Thr Lys Glu Thr Lys Pro Asn Arg Ile Ser Ser Arg Lys Leu Ser 
145                 150                 155                 160 


Glu Glu Cys Asn Ser Leu Ser Asp Val Leu Asp Ala Phe Ser Lys Ala 
                165                 170                 175     


Pro Thr Phe Pro Ser Ser Asn Tyr Phe Thr Ala Met Trp Thr Ile Ala 
            180                 185                 190         


Lys Arg Leu Ser Asp Asp Gln Lys Arg Phe Glu Lys Arg Leu Met Phe 
        195                 200                 205             


Ser His Pro Ala Phe Asn Gln Leu Cys Glu His Met Met Arg Glu Ala 
    210                 215                 220                 


Lys Ile Met Gln Tyr Lys Tyr Leu Leu Phe Ser Leu His Ala Ile Val 
225                 230                 235                 240 


Lys Leu Gly Ile Pro Gln Asn Thr Ile Leu Val Gln Thr Leu Leu Arg 
                245                 250                 255     


Val Thr Gln Glu Arg Ile Asn Glu Cys Asp Glu Ile Cys Leu Ser Val 
            260                 265                 270         


Leu Ser Thr Val Leu Glu Ala Met Glu Pro Cys Lys Asn Val His Val 
        275                 280                 285             


Leu Arg Thr Gly Phe Arg Ile Leu Val Asp Gln Gln Val Trp Lys Ile 
    290                 295                 300                 


Glu Asp Val Phe Thr Leu Gln Val Val Met Lys Cys Ile Gly Lys Asp 
305                 310                 315                 320 


Ala Pro Ile Ala Leu Lys Arg Lys Leu Glu Met Lys Ala Leu Arg Glu 
                325                 330                 335     


Leu Asp Arg Phe Ser Val Leu Asn Ser Gln His Met Phe Glu Val Leu 
            340                 345                 350         


Ala Ala Met Asn His Arg Ser Leu Ile Leu Leu Asp Glu Cys Ser Lys 
        355                 360                 365             


Val Val Leu Asp Asn Ile His Gly Cys Pro Leu Arg Ile Met Ile Asn 
    370                 375                 380                 


Ile Leu Gln Ser Cys Lys Asp Leu Gln Tyr His Asn Leu Asp Leu Phe 
385                 390                 395                 400 


Lys Gly Leu Ala Asp Tyr Val Ala Ala Thr Phe Asp Ile Trp Lys Phe 
                405                 410                 415     


Arg Lys Val Leu Phe Ile Leu Ile Leu Phe Glu Asn Leu Gly Phe Arg 
            420                 425                 430         


Pro Val Gly Leu Met Asp Leu Phe Met Lys Arg Ile Val Glu Asp Pro 
        435                 440                 445             


Glu Ser Leu Asn Met Lys Asn Ile Leu Ser Ile Leu His Thr Tyr Ser 
    450                 455                 460                 


Ser Leu Asn His Val Tyr Lys Cys Gln Asn Lys Glu Gln Phe Val Glu 
465                 470                 475                 480 


Val Met Ala Ser Ala Leu Thr Gly Tyr Leu His Thr Ile Ser Ser Glu 
                485                 490                 495     


Asn Leu Leu Asp Ala Val Tyr Ser Phe Cys Leu Met Asn Tyr Phe Pro 
            500                 505                 510         


Leu Ala Pro Phe Asn Gln Leu Leu Gln Lys Asp Ile Ile Ser Glu Leu 
        515                 520                 525             


Leu Thr Ser Asp Asp Met Lys Asn Ala Tyr Lys Leu His Thr Leu Asp 
    530                 535                 540                 


Thr Cys Leu Lys Leu Asp Asp Thr Val Tyr Leu Arg Asp Ile Ala Leu 
545                 550                 555                 560 


Ser Leu Pro Gln Leu Pro Arg Glu Leu Pro Ser Ser His Thr Asn Ala 
                565                 570                 575     


Lys Val Ala Glu Val Leu Ser Ser Leu Leu Gly Gly Glu Gly His Phe 
            580                 585                 590         


Ser Lys Asp Val His Leu Pro His Asn Tyr His Ile Asp Phe Glu Ile 
        595                 600                 605             


Arg Met Asp Thr Asn Arg Asn Gln Val Leu Pro Leu Ser Asp Val Asp 
    610                 615                 620                 


Thr Thr Ser Ala Thr Asp Ile Gln Arg Val Ala Val Leu Cys Val Ser 
625                 630                 635                 640 


Arg Ser Ala Tyr Cys Leu Gly Ser Ser His Pro Arg Gly Phe Leu Ala 
                645                 650                 655     


Met Lys Met Arg His Leu Asn Ala Met Gly Phe His Val Ile Leu Val 
            660                 665                 670         


Asn Asn Trp Glu Met Asp Lys Leu Glu Met Glu Asp Ala Val Thr Phe 
        675                 680                 685             


Leu Lys Thr Lys Ile Tyr Ser Val Glu Ala Leu Pro Val Ala Ala Val 
    690                 695                 700                 


Asn Val Gln Ser Thr Gln 
705                 710 


<210>  3903
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FASTK__Homo_sapiens__NP_001245390

<400>  3903

Met Arg Arg Pro Arg Gly Glu Pro Gly Pro Arg Ala Pro Arg Pro Thr 
1               5                   10                  15      


Glu Gly Ala Thr Cys Ala Gly Pro Gly Glu Ser Trp Ser Pro Ser Pro 
            20                  25                  30          


Asn Ser Met Leu Arg Val Leu Leu Ser Ala Gln Thr Ser Pro Ala Arg 
        35                  40                  45              


Leu Ser Gly Leu Leu Leu Ile Pro Pro Val Gln Pro Cys Cys Leu Gly 
    50                  55                  60                  


Pro Ser Lys Trp Gly Asp Arg Pro Val Gly Gly Gly Pro Ser Ala Gly 
65                  70                  75                  80  


Pro Val Gln Gly Leu Gln Arg Leu Leu Glu Gln Ala Lys Ser Pro Gly 
                85                  90                  95      


Glu Leu Leu Arg Trp Leu Gly Gln Asn Pro Ser Lys Val Arg Ala His 
            100                 105                 110         


His Tyr Ser Val Ala Leu Arg Arg Leu Gly Gln Leu Leu Gly Ser Arg 
        115                 120                 125             


Pro Arg Pro Pro Pro Val Glu Gln Val Thr Leu Gln Asp Leu Ser Gln 
    130                 135                 140                 


Leu Ile Ile Arg Asn Cys Pro Ser Phe Asp Ile His Thr Ile His Val 
145                 150                 155                 160 


Cys Leu His Leu Ala Val Leu Leu Gly Phe Pro Ser Asp Gly Pro Leu 
                165                 170                 175     


Val Cys Ala Leu Glu Gln Glu Arg Arg Leu Arg Leu Pro Pro Lys Pro 
            180                 185                 190         


Pro Pro Pro Leu Gln Pro Leu Leu Arg Glu Ala Arg Pro Glu Glu Leu 
        195                 200                 205             


Thr Pro His Val Met Val Leu Leu Ala Gln His Leu Ala Arg His Arg 
    210                 215                 220                 


Leu Arg Glu Pro Gln Leu Leu Glu Ala Ile Ala His Phe Leu Val Val 
225                 230                 235                 240 


Gln Glu Thr Gln Leu Ser Ser Lys Val Val Gln Lys Leu Val Leu Pro 
                245                 250                 255     


Phe Gly Arg Leu Asn Tyr Leu Pro Leu Glu Gln Gln Phe Met Pro Cys 
            260                 265                 270         


Leu Glu Arg Ile Leu Ala Arg Glu Ala Gly Val Ala Pro Leu Ala Thr 
        275                 280                 285             


Val Asn Ile Leu Met Ser Leu Cys Gln Leu Arg Cys Leu Pro Phe Arg 
    290                 295                 300                 


Ala Leu His Phe Val Phe Ser Pro Gly Phe Ile Asn Tyr Ile Ser Gly 
305                 310                 315                 320 


Thr Pro His Ala Leu Ile Val Arg Arg Tyr Leu Ser Leu Leu Asp Thr 
                325                 330                 335     


Ala Val Glu Leu Glu Leu Pro Gly Tyr Arg Gly Pro Arg Leu Pro Arg 
            340                 345                 350         


Arg Gln Gln Val Pro Ile Phe Pro Gln Pro Leu Ile Thr Asp Arg Ala 
        355                 360                 365             


Arg Cys Lys Tyr Ser His Lys Asp Ile Val Ala Glu Gly Leu Arg Gln 
    370                 375                 380                 


Leu Leu Gly Glu Glu Lys Tyr Arg Gln Asp Leu Thr Val Pro Pro Gly 
385                 390                 395                 400 


Tyr Cys Thr Asp Phe Leu Leu Cys Ala Ser Ser Ser Gly Ala Val Leu 
                405                 410                 415     


Pro Val Arg Thr Gln Asp Pro Phe Leu Pro Tyr Pro Pro Arg Ser Cys 
            420                 425                 430         


Pro Gln Gly Gln Ala Ala Ser Ser Ala Thr Thr Arg Asp Pro Ala Gln 
        435                 440                 445             


Arg Val Val Leu Val Leu Arg Glu Arg Trp His Phe Cys Arg Asp Gly 
    450                 455                 460                 


Arg Val Leu Leu Gly Ser Arg Ala Leu Arg Glu Arg His Leu Gly Leu 
465                 470                 475                 480 


Met Gly Tyr Gln Leu Leu Pro Leu Pro Phe Glu Glu Leu Glu Ser Gln 
                485                 490                 495     


Arg Gly Leu Pro Gln Leu Lys Ser Tyr Leu Arg Gln Lys Leu Gln Ala 
            500                 505                 510         


Leu Gly Leu Arg Trp Gly Pro Glu Gly Gly 
        515                 520         


<210>  3904
<211>  4588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAT1__Homo_sapiens__XP_006714202

<400>  3904

Met Gly Arg His Leu Ala Leu Leu Leu Leu Leu Leu Leu Leu Phe Gln 
1               5                   10                  15      


His Phe Gly Asp Ser Asp Gly Ser Gln Arg Leu Glu Gln Thr Pro Leu 
            20                  25                  30          


Gln Phe Thr His Leu Glu Tyr Asn Val Thr Val Gln Glu Asn Ser Ala 
        35                  40                  45              


Ala Lys Thr Tyr Val Gly His Pro Val Lys Met Gly Val Tyr Ile Thr 
    50                  55                  60                  


His Pro Ala Trp Glu Val Arg Tyr Lys Ile Val Ser Gly Asp Ser Glu 
65                  70                  75                  80  


Asn Leu Phe Lys Ala Glu Glu Tyr Ile Leu Gly Asp Phe Cys Phe Leu 
                85                  90                  95      


Arg Ile Arg Thr Lys Gly Gly Asn Thr Ala Ile Leu Asn Arg Glu Val 
            100                 105                 110         


Lys Asp His Tyr Thr Leu Ile Val Lys Ala Leu Glu Lys Asn Thr Asn 
        115                 120                 125             


Val Glu Ala Arg Thr Lys Val Arg Val Gln Val Leu Asp Thr Asn Asp 
    130                 135                 140                 


Leu Arg Pro Leu Phe Ser Pro Thr Ser Tyr Ser Val Ser Leu Pro Glu 
145                 150                 155                 160 


Asn Thr Ala Ile Arg Thr Ser Ile Ala Arg Val Ser Ala Thr Asp Ala 
                165                 170                 175     


Asp Ile Gly Thr Asn Gly Glu Phe Tyr Tyr Ser Phe Lys Asp Arg Thr 
            180                 185                 190         


Asp Met Phe Ala Ile His Pro Thr Ser Gly Val Ile Val Leu Thr Gly 
        195                 200                 205             


Arg Leu Asp Tyr Leu Glu Thr Lys Leu Tyr Glu Met Glu Ile Leu Ala 
    210                 215                 220                 


Ala Asp Arg Gly Met Lys Leu Tyr Gly Ser Ser Gly Ile Ser Ser Met 
225                 230                 235                 240 


Ala Lys Leu Thr Val His Ile Glu Gln Ala Asn Glu Cys Ala Pro Val 
                245                 250                 255     


Ile Thr Ala Val Thr Leu Ser Pro Ser Glu Leu Asp Arg Asp Pro Ala 
            260                 265                 270         


Tyr Ala Ile Val Thr Val Asp Asp Cys Asp Gln Gly Ala Asn Gly Asp 
        275                 280                 285             


Ile Ala Ser Leu Ser Ile Val Ala Gly Asp Leu Leu Gln Gln Phe Arg 
    290                 295                 300                 


Thr Val Arg Ser Phe Pro Gly Ser Lys Glu Tyr Lys Val Lys Ala Ile 
305                 310                 315                 320 


Gly Gly Ile Asp Trp Asp Ser His Pro Phe Gly Tyr Asn Leu Thr Leu 
                325                 330                 335     


Gln Ala Lys Asp Lys Gly Thr Pro Pro Gln Phe Ser Ser Val Lys Val 
            340                 345                 350         


Ile His Val Thr Ser Pro Gln Phe Lys Ala Gly Pro Val Lys Phe Glu 
        355                 360                 365             


Lys Asp Val Tyr Arg Ala Glu Ile Ser Glu Phe Ala Pro Pro Asn Thr 
    370                 375                 380                 


Pro Val Val Met Val Lys Ala Ile Pro Ala Tyr Ser His Leu Arg Tyr 
385                 390                 395                 400 


Val Phe Lys Ser Thr Pro Gly Lys Ala Lys Phe Ser Leu Asn Tyr Asn 
                405                 410                 415     


Thr Gly Leu Ile Ser Ile Leu Glu Pro Val Lys Arg Gln Gln Ala Ala 
            420                 425                 430         


His Phe Glu Leu Glu Val Thr Thr Ser Asp Arg Lys Ala Ser Thr Lys 
        435                 440                 445             


Val Leu Val Lys Val Leu Gly Ala Asn Ser Asn Pro Pro Glu Phe Thr 
    450                 455                 460                 


Gln Thr Ala Tyr Lys Ala Ala Phe Asp Glu Asn Val Pro Ile Gly Thr 
465                 470                 475                 480 


Thr Val Met Ser Leu Ser Ala Val Asp Pro Asp Glu Gly Glu Asn Gly 
                485                 490                 495     


Tyr Val Thr Tyr Ser Ile Ala Asn Leu Asn His Val Pro Phe Ala Ile 
            500                 505                 510         


Asp His Phe Thr Gly Ala Val Ser Thr Ser Glu Asn Leu Asp Tyr Glu 
        515                 520                 525             


Leu Met Pro Arg Val Tyr Thr Leu Arg Ile Arg Ala Ser Asp Trp Gly 
    530                 535                 540                 


Leu Pro Tyr Arg Arg Glu Val Glu Val Leu Ala Thr Ile Thr Leu Asn 
545                 550                 555                 560 


Asn Leu Asn Asp Asn Thr Pro Leu Phe Glu Lys Ile Asn Cys Glu Gly 
                565                 570                 575     


Thr Ile Pro Arg Asp Leu Gly Val Gly Glu Gln Ile Thr Thr Val Ser 
            580                 585                 590         


Ala Ile Asp Ala Asp Glu Leu Gln Leu Val Gln Tyr Gln Ile Glu Ala 
        595                 600                 605             


Gly Asn Glu Leu Asp Phe Phe Ser Leu Asn Pro Asn Ser Gly Val Leu 
    610                 615                 620                 


Ser Leu Lys Arg Ser Leu Met Asp Gly Leu Gly Ala Lys Val Ser Phe 
625                 630                 635                 640 


His Ser Leu Arg Ile Thr Ala Thr Asp Gly Glu Asn Phe Ala Thr Pro 
                645                 650                 655     


Leu Tyr Ile Asn Ile Thr Val Ala Ala Ser His Lys Leu Val Asn Leu 
            660                 665                 670         


Gln Cys Glu Glu Thr Gly Val Ala Lys Met Leu Ala Glu Lys Leu Leu 
        675                 680                 685             


Gln Ala Asn Lys Leu His Asn Gln Gly Glu Val Glu Asp Ile Phe Phe 
    690                 695                 700                 


Asp Ser His Ser Val Asn Ala His Ile Pro Gln Phe Arg Ser Thr Leu 
705                 710                 715                 720 


Pro Thr Gly Ile Gln Val Lys Glu Asn Gln Pro Val Gly Ser Ser Val 
                725                 730                 735     


Ile Phe Met Asn Ser Thr Asp Leu Asp Thr Gly Phe Asn Gly Lys Leu 
            740                 745                 750         


Val Tyr Ala Val Ser Gly Gly Asn Glu Asp Ser Cys Phe Met Ile Asp 
        755                 760                 765             


Met Glu Thr Gly Met Leu Lys Ile Leu Ser Pro Leu Asp Arg Glu Thr 
    770                 775                 780                 


Thr Asp Lys Tyr Thr Leu Asn Ile Thr Val Tyr Asp Leu Gly Ile Pro 
785                 790                 795                 800 


Gln Lys Ala Ala Trp Arg Leu Leu His Val Val Val Val Asp Ala Asn 
                805                 810                 815     


Asp Asn Pro Pro Glu Phe Leu Gln Glu Ser Tyr Phe Val Glu Val Ser 
            820                 825                 830         


Glu Asp Lys Glu Val His Ser Glu Ile Ile Gln Val Glu Ala Thr Asp 
        835                 840                 845             


Lys Asp Leu Gly Pro Asn Gly His Val Thr Tyr Ser Ile Val Thr Asp 
    850                 855                 860                 


Thr Asp Thr Phe Ser Ile Asp Ser Val Thr Gly Val Val Asn Ile Ala 
865                 870                 875                 880 


Arg Pro Leu Asp Arg Glu Leu Gln His Glu His Ser Leu Lys Ile Glu 
                885                 890                 895     


Ala Arg Asp Gln Ala Arg Glu Glu Pro Gln Leu Phe Ser Thr Val Val 
            900                 905                 910         


Val Lys Val Ser Leu Glu Asp Val Asn Asp Asn Pro Pro Thr Phe Ile 
        915                 920                 925             


Pro Pro Asn Tyr Arg Val Lys Val Arg Glu Asp Leu Pro Glu Gly Thr 
    930                 935                 940                 


Val Ile Met Trp Leu Glu Ala His Asp Pro Asp Leu Gly Gln Ser Gly 
945                 950                 955                 960 


Gln Val Arg Tyr Ser Leu Leu Asp His Gly Glu Gly Asn Phe Asp Val 
                965                 970                 975     


Asp Lys Leu Ser Gly Ala Val Arg Ile Val Gln Gln Leu Asp Phe Glu 
            980                 985                 990         


Lys Lys Gln Val Tyr Asn Leu Thr  Val Arg Ala Lys Asp  Lys Gly Lys 
        995                 1000                 1005             


Pro Val  Ser Leu Ser Ser Thr  Cys Tyr Val Glu Val  Glu Val Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Asn Leu His  Pro Pro Val Phe Ser  Ser Phe Val 
    1025                 1030                 1035             


Glu Lys  Gly Thr Val Lys Glu  Asp Ala Pro Val Gly  Ser Leu Val 
    1040                 1045                 1050             


Met Thr  Val Ser Ala His Asp  Glu Asp Ala Arg Arg  Asp Gly Glu 
    1055                 1060                 1065             


Ile Arg  Tyr Ser Ile Arg Asp  Gly Ser Gly Val Gly  Val Phe Lys 
    1070                 1075                 1080             


Ile Gly  Glu Glu Thr Gly Val  Ile Glu Thr Ser Asp  Arg Leu Asp 
    1085                 1090                 1095             


Arg Glu  Ser Thr Ser His Tyr  Trp Leu Thr Val Phe  Ala Thr Asp 
    1100                 1105                 1110             


Gln Gly  Val Val Pro Leu Ser  Ser Phe Ile Glu Ile  Tyr Ile Glu 
    1115                 1120                 1125             


Val Glu  Asp Val Asn Asp Asn  Ala Pro Gln Thr Ser  Glu Pro Val 
    1130                 1135                 1140             


Tyr Tyr  Pro Glu Ile Met Glu  Asn Ser Pro Lys Asp  Val Ser Val 
    1145                 1150                 1155             


Val Gln  Ile Glu Ala Phe Asp  Pro Asp Ser Ser Ser  Asn Asp Lys 
    1160                 1165                 1170             


Leu Met  Tyr Lys Ile Thr Ser  Gly Asn Pro Gln Gly  Phe Phe Ser 
    1175                 1180                 1185             


Ile His  Pro Lys Thr Gly Leu  Ile Thr Thr Thr Ser  Arg Lys Leu 
    1190                 1195                 1200             


Asp Arg  Glu Gln Gln Asp Glu  His Ile Leu Glu Val  Thr Val Thr 
    1205                 1210                 1215             


Asp Asn  Gly Ser Pro Pro Lys  Ser Thr Ile Ala Arg  Val Ile Val 
    1220                 1225                 1230             


Lys Ile  Leu Asp Glu Asn Asp  Asn Lys Pro Gln Phe  Leu Gln Lys 
    1235                 1240                 1245             


Phe Tyr  Lys Ile Arg Leu Pro  Glu Arg Glu Lys Pro  Asp Arg Glu 
    1250                 1255                 1260             


Arg Asn  Ala Arg Arg Glu Pro  Leu Tyr His Val Ile  Ala Thr Asp 
    1265                 1270                 1275             


Lys Asp  Glu Gly Pro Asn Ala  Glu Ile Ser Tyr Ser  Ile Glu Asp 
    1280                 1285                 1290             


Gly Asn  Glu His Gly Lys Phe  Phe Ile Glu Pro Lys  Thr Gly Val 
    1295                 1300                 1305             


Val Ser  Ser Lys Arg Phe Ser  Ala Ala Gly Glu Tyr  Asp Ile Leu 
    1310                 1315                 1320             


Ser Ile  Lys Ala Val Asp Asn  Gly Arg Pro Gln Lys  Ser Ser Thr 
    1325                 1330                 1335             


Thr Arg  Leu His Ile Glu Trp  Ile Ser Lys Pro Lys  Pro Ser Leu 
    1340                 1345                 1350             


Glu Pro  Ile Ser Phe Glu Glu  Ser Phe Phe Thr Phe  Thr Val Met 
    1355                 1360                 1365             


Glu Ser  Asp Pro Val Ala His  Met Ile Gly Val Ile  Ser Val Glu 
    1370                 1375                 1380             


Pro Pro  Gly Ile Pro Leu Trp  Phe Asp Ile Thr Gly  Gly Asn Tyr 
    1385                 1390                 1395             


Asp Ser  His Phe Asp Val Asp  Lys Gly Thr Gly Thr  Ile Ile Val 
    1400                 1405                 1410             


Ala Lys  Pro Leu Asp Ala Glu  Gln Lys Ser Asn Tyr  Asn Leu Thr 
    1415                 1420                 1425             


Val Glu  Ala Thr Asp Gly Thr  Thr Thr Ile Leu Thr  Gln Val Phe 
    1430                 1435                 1440             


Ile Lys  Val Ile Asp Thr Asn  Asp His Arg Pro Gln  Phe Ser Thr 
    1445                 1450                 1455             


Ser Lys  Tyr Glu Val Val Ile  Pro Glu Asp Thr Ala  Pro Glu Thr 
    1460                 1465                 1470             


Glu Ile  Leu Gln Ile Ser Ala  Val Asp Gln Asp Glu  Lys Asn Lys 
    1475                 1480                 1485             


Leu Ile  Tyr Thr Leu Gln Ser  Ser Arg Asp Pro Leu  Ser Leu Lys 
    1490                 1495                 1500             


Lys Phe  Arg Leu Asp Pro Ala  Thr Gly Ser Leu Tyr  Thr Ser Glu 
    1505                 1510                 1515             


Lys Leu  Asp His Glu Ala Val  His Gln His Thr Leu  Thr Val Met 
    1520                 1525                 1530             


Val Arg  Asp Gln Asp Val Pro  Val Lys Arg Asn Phe  Ala Arg Ile 
    1535                 1540                 1545             


Val Val  Asn Val Ser Asp Thr  Asn Asp His Ala Pro  Trp Phe Thr 
    1550                 1555                 1560             


Ala Ser  Ser Tyr Lys Gly Arg  Val Tyr Glu Ser Ala  Ala Val Gly 
    1565                 1570                 1575             


Ser Val  Val Leu Gln Val Thr  Ala Leu Asp Lys Asp  Lys Gly Lys 
    1580                 1585                 1590             


Asn Ala  Glu Val Leu Tyr Ser  Ile Glu Ser Gly Asn  Ile Gly Asn 
    1595                 1600                 1605             


Ser Phe  Met Ile Asp Pro Val  Leu Gly Ser Ile Lys  Thr Ala Lys 
    1610                 1615                 1620             


Glu Leu  Asp Arg Ser Asn Gln  Ala Glu Tyr Asp Leu  Met Val Lys 
    1625                 1630                 1635             


Ala Thr  Asp Lys Gly Ser Pro  Pro Met Ser Glu Ile  Thr Ser Val 
    1640                 1645                 1650             


Arg Ile  Phe Val Thr Ile Ala  Asp Asn Ala Ser Pro  Lys Phe Thr 
    1655                 1660                 1665             


Ser Lys  Glu Tyr Ser Val Glu  Leu Ser Glu Thr Val  Ser Ile Gly 
    1670                 1675                 1680             


Ser Phe  Val Gly Met Val Thr  Ala His Ser Gln Ser  Ser Val Val 
    1685                 1690                 1695             


Tyr Glu  Ile Lys Asp Gly Asn  Thr Gly Asp Ala Phe  Asp Ile Asn 
    1700                 1705                 1710             


Pro His  Ser Gly Thr Ile Ile  Thr Gln Lys Ala Leu  Asp Phe Glu 
    1715                 1720                 1725             


Thr Leu  Pro Ile Tyr Thr Leu  Ile Ile Gln Gly Thr  Asn Met Ala 
    1730                 1735                 1740             


Gly Leu  Ser Thr Asn Thr Thr  Val Leu Val His Leu  Gln Asp Glu 
    1745                 1750                 1755             


Asn Asp  Asn Ala Pro Val Phe  Met Gln Ala Glu Tyr  Thr Gly Leu 
    1760                 1765                 1770             


Ile Ser  Glu Ser Ala Ser Ile  Asn Ser Val Val Leu  Thr Asp Arg 
    1775                 1780                 1785             


Asn Val  Pro Leu Val Ile Arg  Ala Ala Asp Ala Asp  Lys Asp Ser 
    1790                 1795                 1800             


Asn Ala  Leu Leu Val Tyr His  Ile Val Glu Pro Ser  Val His Thr 
    1805                 1810                 1815             


Tyr Phe  Ala Ile Asp Ser Ser  Thr Gly Ala Ile His  Thr Val Leu 
    1820                 1825                 1830             


Ser Leu  Asp Tyr Glu Glu Thr  Ser Ile Phe His Phe  Thr Val Gln 
    1835                 1840                 1845             


Val His  Asp Met Gly Thr Pro  Arg Leu Phe Ala Glu  Tyr Ala Ala 
    1850                 1855                 1860             


Asn Val  Thr Val His Val Ile  Asp Ile Asn Asp Cys  Pro Pro Val 
    1865                 1870                 1875             


Phe Ala  Lys Pro Leu Tyr Glu  Ala Ser Leu Leu Leu  Pro Thr Tyr 
    1880                 1885                 1890             


Lys Gly  Val Lys Val Ile Thr  Val Asn Ala Thr Asp  Ala Asp Ser 
    1895                 1900                 1905             


Ser Ala  Phe Ser Gln Leu Ile  Tyr Ser Ile Thr Glu  Gly Asn Ile 
    1910                 1915                 1920             


Gly Glu  Lys Phe Ser Met Asp  Tyr Lys Thr Gly Ala  Leu Thr Val 
    1925                 1930                 1935             


Gln Asn  Thr Thr Gln Leu Arg  Ser Arg Tyr Glu Leu  Thr Val Arg 
    1940                 1945                 1950             


Ala Ser  Asp Gly Arg Phe Ala  Gly Leu Thr Ser Val  Lys Ile Asn 
    1955                 1960                 1965             


Val Lys  Glu Ser Lys Glu Ser  His Leu Lys Phe Thr  Gln Asp Val 
    1970                 1975                 1980             


Tyr Ser  Ala Val Val Lys Glu  Asn Ser Thr Glu Ala  Glu Thr Leu 
    1985                 1990                 1995             


Ala Val  Ile Thr Ala Ile Gly  Asn Pro Ile Asn Glu  Pro Leu Phe 
    2000                 2005                 2010             


Tyr His  Ile Leu Asn Pro Asp  Arg Arg Phe Lys Ile  Ser Arg Thr 
    2015                 2020                 2025             


Ser Gly  Val Leu Ser Thr Thr  Gly Thr Pro Phe Asp  Arg Glu Gln 
    2030                 2035                 2040             


Gln Glu  Ala Phe Asp Val Val  Val Glu Val Thr Glu  Glu His Lys 
    2045                 2050                 2055             


Pro Ser  Ala Val Ala His Val  Val Val Lys Val Ile  Val Glu Asp 
    2060                 2065                 2070             


Gln Asn  Asp Asn Ala Pro Val  Phe Val Asn Leu Pro  Tyr Tyr Ala 
    2075                 2080                 2085             


Val Val  Lys Val Asp Thr Glu  Val Gly His Val Ile  Arg Tyr Val 
    2090                 2095                 2100             


Thr Ala  Val Asp Arg Asp Ser  Gly Arg Asn Gly Glu  Val His Tyr 
    2105                 2110                 2115             


Tyr Leu  Lys Glu His His Glu  His Phe Gln Ile Gly  Pro Leu Gly 
    2120                 2125                 2130             


Glu Ile  Ser Leu Lys Lys Gln  Phe Glu Leu Asp Thr  Leu Asn Lys 
    2135                 2140                 2145             


Glu Tyr  Leu Val Thr Val Val  Ala Lys Asp Gly Gly  Asn Pro Ala 
    2150                 2155                 2160             


Phe Ser  Ala Glu Val Ile Val  Pro Ile Thr Val Met  Asn Lys Ala 
    2165                 2170                 2175             


Met Pro  Val Phe Glu Lys Pro  Phe Tyr Ser Ala Glu  Ile Ala Glu 
    2180                 2185                 2190             


Ser Ile  Gln Val His Ser Pro  Val Val His Val Gln  Ala Asn Ser 
    2195                 2200                 2205             


Pro Glu  Gly Leu Lys Val Phe  Tyr Ser Ile Thr Asp  Gly Asp Pro 
    2210                 2215                 2220             


Phe Ser  Gln Phe Thr Ile Asn  Phe Asn Thr Gly Val  Ile Asn Val 
    2225                 2230                 2235             


Ile Ala  Pro Leu Asp Phe Glu  Ala His Pro Ala Tyr  Lys Leu Ser 
    2240                 2245                 2250             


Ile Arg  Ala Thr Asp Ser Leu  Thr Gly Ala His Ala  Glu Val Phe 
    2255                 2260                 2265             


Val Asp  Ile Ile Val Asp Asp  Ile Asn Asp Asn Pro  Pro Val Phe 
    2270                 2275                 2280             


Ala Gln  Gln Ser Tyr Ala Val  Thr Leu Ser Glu Ala  Ser Val Ile 
    2285                 2290                 2295             


Gly Thr  Ser Val Val Gln Val  Arg Ala Thr Asp Ser  Asp Ser Glu 
    2300                 2305                 2310             


Pro Asn  Arg Gly Ile Ser Tyr  Gln Met Phe Gly Asn  His Ser Lys 
    2315                 2320                 2325             


Ser His  Asp His Phe His Val  Asp Ser Ser Thr Gly  Leu Ile Ser 
    2330                 2335                 2340             


Leu Leu  Arg Thr Leu Asp Tyr  Glu Gln Ser Arg Gln  His Thr Ile 
    2345                 2350                 2355             


Phe Val  Arg Ala Val Asp Gly  Gly Met Pro Thr Leu  Ser Ser Asp 
    2360                 2365                 2370             


Val Ile  Val Thr Val Asp Val  Thr Asp Leu Asn Asp  Asn Pro Pro 
    2375                 2380                 2385             


Leu Phe  Glu Gln Gln Ile Tyr  Glu Ala Arg Ile Ser  Glu His Ala 
    2390                 2395                 2400             


Pro His  Gly His Phe Val Thr  Cys Val Lys Ala Tyr  Asp Ala Asp 
    2405                 2410                 2415             


Ser Ser  Asp Ile Asp Lys Leu  Gln Tyr Ser Ile Leu  Ser Gly Asn 
    2420                 2425                 2430             


Asp His  Lys His Phe Val Ile  Asp Ser Ala Thr Gly  Ile Ile Thr 
    2435                 2440                 2445             


Leu Ser  Asn Leu His Arg His  Ala Leu Lys Pro Phe  Tyr Ser Leu 
    2450                 2455                 2460             


Asn Leu  Ser Val Ser Asp Gly  Val Phe Arg Ser Ser  Thr Gln Val 
    2465                 2470                 2475             


His Val  Thr Val Ile Gly Gly  Asn Leu His Ser Pro  Ala Phe Leu 
    2480                 2485                 2490             


Gln Asn  Glu Tyr Glu Val Glu  Leu Ala Glu Asn Ala  Pro Leu His 
    2495                 2500                 2505             


Thr Leu  Val Met Glu Val Lys  Thr Thr Asp Gly Asp  Ser Gly Ile 
    2510                 2515                 2520             


Tyr Gly  His Val Thr Tyr His  Ile Val Asn Asp Phe  Ala Lys Asp 
    2525                 2530                 2535             


Arg Phe  Tyr Ile Asn Glu Arg  Gly Gln Ile Phe Thr  Leu Glu Lys 
    2540                 2545                 2550             


Leu Asp  Arg Glu Thr Pro Ala  Glu Lys Val Ile Ser  Val Arg Leu 
    2555                 2560                 2565             


Met Ala  Lys Asp Ala Gly Gly  Lys Val Ala Phe Cys  Thr Val Asn 
    2570                 2575                 2580             


Val Ile  Leu Thr Asp Asp Asn  Asp Asn Ala Pro Gln  Phe Arg Ala 
    2585                 2590                 2595             


Thr Lys  Tyr Glu Val Asn Ile  Gly Ser Ser Ala Ala  Lys Gly Thr 
    2600                 2605                 2610             


Ser Val  Val Lys Val Leu Ala  Ser Asp Ala Asp Glu  Gly Ser Asn 
    2615                 2620                 2625             


Ala Asp  Ile Thr Tyr Ala Ile  Glu Ala Asp Ser Glu  Ser Val Lys 
    2630                 2635                 2640             


Glu Asn  Leu Glu Ile Asn Lys  Leu Ser Gly Val Ile  Thr Thr Lys 
    2645                 2650                 2655             


Glu Ser  Leu Ile Gly Leu Glu  Asn Glu Phe Phe Thr  Phe Phe Val 
    2660                 2665                 2670             


Arg Ala  Val Asp Asn Gly Ser  Pro Ser Lys Glu Ser  Val Val Leu 
    2675                 2680                 2685             


Val Tyr  Val Lys Ile Leu Pro  Pro Glu Met Gln Leu  Pro Lys Phe 
    2690                 2695                 2700             


Ser Glu  Pro Phe Tyr Thr Phe  Thr Val Ser Glu Asp  Val Pro Ile 
    2705                 2710                 2715             


Gly Thr  Glu Ile Asp Leu Ile  Arg Ala Glu His Ser  Gly Thr Val 
    2720                 2725                 2730             


Leu Tyr  Ser Leu Val Lys Gly  Asn Thr Pro Glu Ser  Asn Arg Asp 
    2735                 2740                 2745             


Glu Ser  Phe Val Ile Asp Arg  Gln Ser Gly Arg Leu  Lys Leu Glu 
    2750                 2755                 2760             


Lys Ser  Leu Asp His Glu Thr  Thr Lys Trp Tyr Gln  Phe Ser Ile 
    2765                 2770                 2775             


Leu Ala  Arg Cys Thr Gln Asp  Asp His Glu Met Val  Ala Ser Val 
    2780                 2785                 2790             


Asp Val  Ser Ile Gln Val Lys  Asp Ala Asn Asp Asn  Ser Pro Val 
    2795                 2800                 2805             


Phe Glu  Ser Ser Pro Tyr Glu  Ala Phe Ile Val Glu  Asn Leu Pro 
    2810                 2815                 2820             


Gly Gly  Ser Arg Val Ile Gln  Ile Arg Ala Ser Asp  Ala Asp Ser 
    2825                 2830                 2835             


Gly Thr  Asn Gly Gln Val Met  Tyr Ser Leu Asp Gln  Ser Gln Ser 
    2840                 2845                 2850             


Val Glu  Val Ile Glu Ser Phe  Ala Ile Asn Met Glu  Thr Gly Trp 
    2855                 2860                 2865             


Ile Thr  Thr Leu Lys Glu Leu  Asp His Glu Lys Arg  Asp Asn Tyr 
    2870                 2875                 2880             


Gln Ile  Lys Val Val Ala Ser  Asp His Gly Glu Lys  Ile Gln Leu 
    2885                 2890                 2895             


Ser Ser  Thr Ala Ile Val Asp  Val Thr Val Thr Asp  Val Asn Asp 
    2900                 2905                 2910             


Ser Pro  Pro Arg Phe Thr Ala  Glu Ile Tyr Lys Gly  Thr Val Ser 
    2915                 2920                 2925             


Glu Asp  Asp Pro Gln Gly Gly  Val Ile Ala Ile Leu  Ser Thr Thr 
    2930                 2935                 2940             


Asp Ala  Asp Ser Glu Glu Ile  Asn Arg Gln Val Thr  Tyr Phe Ile 
    2945                 2950                 2955             


Thr Gly  Gly Asp Pro Leu Gly  Gln Phe Ala Val Glu  Thr Ile Gln 
    2960                 2965                 2970             


Asn Glu  Trp Lys Val Tyr Val  Lys Lys Pro Leu Asp  Arg Glu Lys 
    2975                 2980                 2985             


Arg Asp  Asn Tyr Leu Leu Thr  Ile Thr Ala Thr Asp  Gly Thr Phe 
    2990                 2995                 3000             


Ser Ser  Lys Ala Ile Val Glu  Val Lys Val Leu Asp  Ala Asn Asp 
    3005                 3010                 3015             


Asn Ser  Pro Val Cys Glu Lys  Thr Leu Tyr Ser Asp  Thr Ile Pro 
    3020                 3025                 3030             


Glu Asp  Val Leu Pro Gly Lys  Leu Ile Met Gln Ile  Ser Ala Thr 
    3035                 3040                 3045             


Asp Ala  Asp Ile Arg Ser Asn  Ala Glu Ile Thr Tyr  Thr Leu Leu 
    3050                 3055                 3060             


Gly Ser  Gly Ala Glu Lys Phe  Lys Leu Asn Pro Asp  Thr Gly Glu 
    3065                 3070                 3075             


Leu Lys  Thr Ser Thr Pro Leu  Asp Arg Glu Glu Gln  Ala Val Tyr 
    3080                 3085                 3090             


His Leu  Leu Val Arg Ala Thr  Asp Gly Gly Gly Arg  Phe Cys Gln 
    3095                 3100                 3105             


Ala Ser  Ile Val Leu Thr Leu  Glu Asp Val Asn Asp  Asn Ala Pro 
    3110                 3115                 3120             


Glu Phe  Ser Ala Asp Pro Tyr  Ala Ile Thr Val Phe  Glu Asn Thr 
    3125                 3130                 3135             


Glu Pro  Gly Thr Leu Leu Thr  Arg Val Gln Ala Thr  Asp Ala Asp 
    3140                 3145                 3150             


Ala Gly  Leu Asn Arg Lys Ile  Leu Tyr Ser Leu Ile  Asp Ser Ala 
    3155                 3160                 3165             


Asp Gly  Gln Phe Ser Ile Asn  Glu Leu Ser Gly Ile  Ile Gln Leu 
    3170                 3175                 3180             


Glu Lys  Pro Leu Asp Arg Glu  Leu Gln Ala Val Tyr  Thr Leu Ser 
    3185                 3190                 3195             


Leu Lys  Ala Val Asp Gln Gly  Leu Pro Arg Arg Leu  Thr Ala Thr 
    3200                 3205                 3210             


Gly Thr  Val Ile Val Ser Val  Leu Asp Ile Asn Asp  Asn Pro Pro 
    3215                 3220                 3225             


Val Phe  Glu Tyr Arg Glu Tyr  Gly Ala Thr Val Ser  Glu Asp Ile 
    3230                 3235                 3240             


Leu Val  Gly Thr Glu Val Leu  Gln Val Tyr Ala Ala  Ser Arg Asp 
    3245                 3250                 3255             


Ile Glu  Ala Asn Ala Glu Ile  Thr Tyr Ser Ile Ile  Ser Gly Asn 
    3260                 3265                 3270             


Glu His  Gly Lys Phe Ser Ile  Asp Ser Lys Thr Gly  Ala Val Phe 
    3275                 3280                 3285             


Ile Ile  Glu Asn Leu Asp Tyr  Glu Ser Ser His Glu  Tyr Tyr Leu 
    3290                 3295                 3300             


Thr Val  Glu Ala Thr Asp Gly  Gly Thr Pro Ser Leu  Ser Asp Val 
    3305                 3310                 3315             


Ala Thr  Val Asn Val Asn Val  Thr Asp Ile Asn Asp  Asn Thr Pro 
    3320                 3325                 3330             


Val Phe  Ser Gln Asp Thr Tyr  Thr Thr Val Ile Ser  Glu Asp Ala 
    3335                 3340                 3345             


Val Leu  Glu Gln Ser Val Ile  Thr Val Met Ala Asp  Asp Ala Asp 
    3350                 3355                 3360             


Gly Pro  Ser Asn Ser His Ile  His Tyr Ser Ile Ile  Asp Gly Asn 
    3365                 3370                 3375             


Gln Gly  Ser Ser Phe Thr Ile  Asp Pro Val Arg Gly  Glu Val Lys 
    3380                 3385                 3390             


Val Thr  Lys Leu Leu Asp Arg  Glu Thr Ile Ser Gly  Tyr Thr Leu 
    3395                 3400                 3405             


Thr Val  Gln Ala Ser Asp Asn  Gly Ser Pro Pro Arg  Val Asn Thr 
    3410                 3415                 3420             


Thr Thr  Val Asn Ile Asp Val  Ser Asp Val Asn Asp  Asn Ala Pro 
    3425                 3430                 3435             


Val Phe  Ser Arg Gly Asn Tyr  Ser Val Ile Ile Gln  Glu Asn Lys 
    3440                 3445                 3450             


Pro Val  Gly Phe Ser Val Leu  Gln Leu Val Val Thr  Asp Glu Asp 
    3455                 3460                 3465             


Ser Ser  His Asn Gly Pro Pro  Phe Phe Phe Thr Ile  Val Thr Gly 
    3470                 3475                 3480             


Asn Asp  Glu Lys Ala Phe Glu  Val Asn Pro Gln Gly  Val Leu Leu 
    3485                 3490                 3495             


Thr Ser  Ser Ala Ile Lys Arg  Lys Glu Lys Asp His  Tyr Leu Leu 
    3500                 3505                 3510             


Gln Val  Lys Val Ala Asp Asn  Gly Lys Pro Gln Leu  Ser Ser Leu 
    3515                 3520                 3525             


Thr Tyr  Ile Asp Ile Arg Val  Ile Glu Glu Ser Ile  Tyr Pro Pro 
    3530                 3535                 3540             


Ala Ile  Leu Pro Leu Glu Ile  Phe Ile Thr Ser Ser  Gly Glu Glu 
    3545                 3550                 3555             


Tyr Ser  Gly Gly Val Ile Gly  Lys Ile His Ala Thr  Asp Gln Asp 
    3560                 3565                 3570             


Val Tyr  Asp Thr Leu Thr Tyr  Ser Leu Asp Pro Gln  Met Asp Asn 
    3575                 3580                 3585             


Leu Phe  Ser Val Ser Ser Thr  Gly Gly Lys Leu Ile  Ala His Lys 
    3590                 3595                 3600             


Lys Leu  Asp Ile Gly Gln Tyr  Leu Leu Asn Val Ser  Val Thr Asp 
    3605                 3610                 3615             


Gly Lys  Phe Thr Thr Val Ala  Asp Ile Thr Val His  Ile Arg Gln 
    3620                 3625                 3630             


Val Thr  Gln Glu Met Leu Asn  His Thr Ile Ala Ile  Arg Phe Ala 
    3635                 3640                 3645             


Asn Leu  Thr Pro Glu Glu Phe  Val Gly Asp Tyr Trp  Arg Asn Phe 
    3650                 3655                 3660             


Gln Arg  Ala Leu Arg Asn Ile  Leu Gly Val Arg Arg  Asn Asp Ile 
    3665                 3670                 3675             


Gln Ile  Val Ser Leu Gln Ser  Ser Glu Pro His Pro  His Leu Asp 
    3680                 3685                 3690             


Val Leu  Leu Phe Val Glu Lys  Pro Gly Ser Ala Gln  Ile Ser Thr 
    3695                 3700                 3705             


Lys Gln  Leu Leu His Lys Ile  Asn Ser Ser Val Thr  Asp Ile Glu 
    3710                 3715                 3720             


Glu Ile  Ile Gly Val Arg Ile  Leu Asn Val Phe Gln  Lys Leu Cys 
    3725                 3730                 3735             


Ala Gly  Leu Asp Cys Pro Trp  Lys Phe Cys Asp Glu  Lys Val Ser 
    3740                 3745                 3750             


Val Asp  Glu Ser Val Met Ser  Thr His Ser Thr Ala  Arg Leu Ser 
    3755                 3760                 3765             


Phe Val  Thr Pro Arg His His  Arg Ala Ala Val Cys  Leu Cys Lys 
    3770                 3775                 3780             


Glu Gly  Arg Cys Pro Pro Val  His His Gly Cys Glu  Asp Asp Pro 
    3785                 3790                 3795             


Cys Pro  Glu Gly Ser Glu Cys  Val Ser Asp Pro Trp  Glu Glu Lys 
    3800                 3805                 3810             


His Thr  Cys Val Cys Pro Ser  Gly Arg Phe Gly Gln  Cys Pro Gly 
    3815                 3820                 3825             


Ser Ser  Ser Met Thr Leu Thr  Gly Asn Ser Tyr Val  Lys Tyr Arg 
    3830                 3835                 3840             


Leu Thr  Glu Asn Glu Asn Lys  Leu Glu Met Lys Leu  Thr Met Arg 
    3845                 3850                 3855             


Leu Arg  Thr Tyr Ser Thr His  Ala Val Val Met Tyr  Ala Arg Gly 
    3860                 3865                 3870             


Thr Asp  Tyr Ser Ile Leu Glu  Ile His His Gly Arg  Leu Gln Tyr 
    3875                 3880                 3885             


Lys Phe  Asp Cys Gly Ser Gly  Pro Gly Ile Val Ser  Val Gln Ser 
    3890                 3895                 3900             


Ile Gln  Val Asn Asp Gly Gln  Trp His Ala Val Ala  Leu Glu Val 
    3905                 3910                 3915             


Asn Gly  Asn Tyr Ala Arg Leu  Val Leu Asp Gln Val  His Thr Ala 
    3920                 3925                 3930             


Ser Gly  Thr Ala Pro Gly Thr  Leu Lys Thr Leu Asn  Leu Asp Asn 
    3935                 3940                 3945             


Tyr Val  Phe Phe Gly Gly His  Ile Arg Gln Gln Gly  Thr Arg His 
    3950                 3955                 3960             


Gly Arg  Ser Pro Gln Val Gly  Asn Gly Phe Arg Gly  Cys Met Asp 
    3965                 3970                 3975             


Ser Ile  Tyr Leu Asn Gly Gln  Glu Leu Pro Leu Asn  Ser Lys Pro 
    3980                 3985                 3990             


Arg Ser  Tyr Ala His Ile Glu  Glu Ser Val Asp Val  Ser Pro Gly 
    3995                 4000                 4005             


Cys Phe  Leu Thr Ala Thr Glu  Asp Cys Ala Ser Asn  Pro Cys Gln 
    4010                 4015                 4020             


Asn Gly  Gly Val Cys Asn Pro  Ser Pro Ala Gly Gly  Tyr Tyr Cys 
    4025                 4030                 4035             


Lys Cys  Ser Ala Leu Tyr Ile  Gly Thr His Cys Glu  Ile Ser Val 
    4040                 4045                 4050             


Asn Pro  Cys Ser Ser Lys Pro  Cys Leu Tyr Gly Gly  Thr Cys Val 
    4055                 4060                 4065             


Val Asp  Asn Gly Gly Phe Val  Cys Gln Cys Arg Gly  Leu Tyr Thr 
    4070                 4075                 4080             


Gly Gln  Arg Cys Gln Leu Ser  Pro Tyr Cys Lys Asp  Glu Pro Cys 
    4085                 4090                 4095             


Lys Asn  Gly Gly Thr Cys Phe  Asp Ser Leu Asp Gly  Ala Val Cys 
    4100                 4105                 4110             


Gln Cys  Asp Ser Gly Phe Arg  Gly Glu Arg Cys Gln  Ser Asp Ile 
    4115                 4120                 4125             


Asp Glu  Cys Ser Gly Asn Pro  Cys Leu His Gly Ala  Leu Cys Glu 
    4130                 4135                 4140             


Asn Thr  His Gly Ser Tyr His  Cys Asn Cys Ser His  Glu Tyr Arg 
    4145                 4150                 4155             


Gly Arg  His Cys Glu Asp Ala  Ala Pro Asn Gln Tyr  Val Ser Thr 
    4160                 4165                 4170             


Pro Trp  Asn Ile Gly Leu Ala  Glu Gly Ile Gly Ile  Val Val Phe 
    4175                 4180                 4185             


Val Ala  Gly Ile Phe Leu Leu  Val Val Val Phe Val  Leu Cys Arg 
    4190                 4195                 4200             


Lys Met  Ile Ser Arg Lys Lys  Lys His Gln Ala Glu  Pro Lys Asp 
    4205                 4210                 4215             


Lys His  Leu Gly Pro Ala Thr  Ala Phe Leu Gln Arg  Pro Tyr Phe 
    4220                 4225                 4230             


Asp Ser  Lys Leu Asn Lys Asn  Ile Tyr Ser Asp Ile  Pro Pro Gln 
    4235                 4240                 4245             


Val Pro  Val Arg Pro Ile Ser  Tyr Thr Pro Ser Ile  Pro Ser Asp 
    4250                 4255                 4260             


Ser Arg  Asn Asn Leu Asp Arg  Asn Ser Phe Glu Gly  Ser Ala Ile 
    4265                 4270                 4275             


Pro Glu  His Pro Glu Phe Ser  Thr Phe Asn Pro Glu  Ser Val His 
    4280                 4285                 4290             


Gly His  Arg Lys Ala Val Ala  Val Cys Ser Val Ala  Pro Asn Leu 
    4295                 4300                 4305             


Pro Pro  Pro Pro Pro Ser Asn  Ser Pro Ser Asp Ser  Asp Ser Ile 
    4310                 4315                 4320             


Gln Lys  Pro Ser Trp Asp Phe  Asp Tyr Asp Thr Lys  Val Val Asp 
    4325                 4330                 4335             


Leu Asp  Pro Cys Leu Ser Lys  Lys Pro Leu Glu Glu  Lys Pro Ser 
    4340                 4345                 4350             


Gln Pro  Tyr Ser Ala Arg Glu  Ser Leu Ser Glu Val  Gln Ser Leu 
    4355                 4360                 4365             


Ser Ser  Phe Gln Ser Glu Ser  Cys Asp Asp Asn Gly  Tyr His Trp 
    4370                 4375                 4380             


Asp Thr  Ser Asp Trp Met Pro  Ser Val Pro Leu Pro  Asp Ile Gln 
    4385                 4390                 4395             


Glu Phe  Pro Asn Tyr Glu Val  Ile Asp Glu Gln Thr  Pro Leu Tyr 
    4400                 4405                 4410             


Ser Ala  Asp Pro Asn Ala Ile  Asp Thr Asp Tyr Tyr  Pro Gly Gly 
    4415                 4420                 4425             


Tyr Asp  Ile Glu Ser Asp Phe  Pro Pro Pro Pro Glu  Asp Phe Pro 
    4430                 4435                 4440             


Ala Ala  Asp Glu Leu Pro Pro  Leu Pro Pro Glu Phe  Ser Asn Gln 
    4445                 4450                 4455             


Phe Glu  Ser Ile His Pro Pro  Arg Asp Met Pro Ala  Ala Gly Ser 
    4460                 4465                 4470             


Leu Gly  Ser Ser Ser Arg Asn  Arg Gln Arg Phe Asn  Leu Asn Gln 
    4475                 4480                 4485             


Tyr Leu  Pro Asn Phe Tyr Pro  Leu Asp Met Ser Glu  Pro Gln Thr 
    4490                 4495                 4500             


Lys Gly  Thr Gly Glu Asn Ser  Thr Cys Arg Glu Pro  His Ala Pro 
    4505                 4510                 4515             


Tyr Pro  Pro Gly Tyr Gln Arg  His Phe Glu Ala Pro  Ala Val Glu 
    4520                 4525                 4530             


Ser Met  Pro Met Ser Val Tyr  Ala Ser Thr Ala Ser  Cys Ser Asp 
    4535                 4540                 4545             


Val Ser  Ala Cys Cys Glu Val  Glu Ser Glu Val Met  Met Ser Asp 
    4550                 4555                 4560             


Tyr Glu  Ser Gly Asp Asp Gly  His Phe Glu Glu Val  Thr Ile Pro 
    4565                 4570                 4575             


Pro Leu  Asp Ser Gln Gln His  Thr Glu Val 
    4580                 4585             


<210>  3905
<211>  4349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAT2__Homo_sapiens__XP_011535905

<400>  3905

Met Thr Ile Ala Leu Leu Gly Phe Ala Ile Phe Leu Leu His Cys Ala 
1               5                   10                  15      


Thr Cys Glu Lys Pro Leu Glu Gly Ile Leu Ser Ser Ser Ala Trp His 
            20                  25                  30          


Phe Thr His Ser His Tyr Asn Ala Thr Ile Tyr Glu Asn Ser Ser Pro 
        35                  40                  45              


Lys Thr Tyr Val Glu Ser Phe Glu Lys Met Gly Ile Tyr Leu Ala Glu 
    50                  55                  60                  


Pro Gln Trp Ala Val Arg Tyr Arg Ile Ile Ser Gly Asp Val Ala Asn 
65                  70                  75                  80  


Val Phe Lys Thr Glu Glu Tyr Val Val Gly Asn Phe Cys Phe Leu Arg 
                85                  90                  95      


Ile Arg Thr Lys Ser Ser Asn Thr Ala Leu Leu Asn Arg Glu Val Arg 
            100                 105                 110         


Asp Ser Tyr Thr Leu Ile Ile Gln Ala Thr Glu Lys Thr Leu Glu Leu 
        115                 120                 125             


Glu Ala Leu Thr Arg Val Val Val His Ile Leu Asp Gln Asn Asp Leu 
    130                 135                 140                 


Lys Pro Leu Phe Ser Pro Pro Ser Tyr Arg Val Thr Ile Ser Glu Asp 
145                 150                 155                 160 


Met Pro Leu Lys Ser Pro Ile Cys Lys Val Thr Ala Thr Asp Ala Asp 
                165                 170                 175     


Leu Gly Gln Asn Ala Glu Phe Tyr Tyr Ala Phe Asn Thr Arg Ser Glu 
            180                 185                 190         


Met Phe Ala Ile His Pro Thr Ser Gly Val Val Thr Val Ala Gly Lys 
        195                 200                 205             


Leu Asn Val Thr Trp Arg Gly Lys His Glu Leu Gln Val Leu Ala Val 
    210                 215                 220                 


Asp Arg Met Arg Lys Ile Ser Glu Gly Asn Gly Phe Gly Ser Leu Ala 
225                 230                 235                 240 


Ala Leu Val Val His Val Glu Pro Ala Leu Arg Lys Pro Pro Ala Ile 
                245                 250                 255     


Ala Ser Val Val Val Thr Pro Pro Asp Ser Asn Asp Gly Thr Thr Tyr 
            260                 265                 270         


Ala Thr Val Leu Val Asp Ala Asn Ser Ser Gly Ala Glu Val Glu Ser 
        275                 280                 285             


Val Glu Val Val Gly Gly Asp Pro Gly Lys His Phe Lys Ala Ile Lys 
    290                 295                 300                 


Ser Tyr Ala Arg Ser Asn Glu Phe Ser Leu Val Ser Val Lys Asp Ile 
305                 310                 315                 320 


Asn Trp Met Glu Tyr Leu His Gly Phe Asn Leu Ser Leu Gln Ala Arg 
                325                 330                 335     


Ser Gly Ser Gly Pro Tyr Phe Tyr Ser Gln Ile Arg Gly Phe His Leu 
            340                 345                 350         


Pro Pro Ser Lys Leu Ser Ser Leu Lys Phe Glu Lys Ala Val Tyr Arg 
        355                 360                 365             


Val Gln Leu Ser Glu Phe Ser Pro Pro Gly Ser Arg Val Val Met Val 
    370                 375                 380                 


Arg Val Thr Pro Ala Phe Pro Asn Leu Gln Tyr Val Leu Lys Pro Ser 
385                 390                 395                 400 


Ser Glu Asn Val Gly Phe Lys Leu Asn Ala Arg Thr Gly Leu Ile Thr 
                405                 410                 415     


Thr Thr Lys Leu Met Asp Phe His Asp Arg Ala His Tyr Gln Leu His 
            420                 425                 430         


Ile Arg Thr Ser Pro Gly Gln Ala Ser Thr Val Val Val Ile Asp Ile 
        435                 440                 445             


Val Asp Cys Asn Asn His Ala Pro Leu Phe Asn Arg Ser Ser Tyr Asp 
    450                 455                 460                 


Gly Thr Leu Asp Glu Asn Ile Pro Pro Gly Thr Ser Val Leu Ala Val 
465                 470                 475                 480 


Thr Ala Thr Asp Arg Asp His Gly Glu Asn Gly Tyr Val Thr Tyr Ser 
                485                 490                 495     


Ile Ala Gly Pro Lys Ala Leu Pro Phe Ser Ile Asp Pro Tyr Leu Gly 
            500                 505                 510         


Ile Ile Ser Thr Ser Lys Pro Met Asp Tyr Glu Leu Met Lys Arg Ile 
        515                 520                 525             


Tyr Thr Phe Arg Val Arg Ala Ser Asp Trp Gly Ser Pro Phe Arg Arg 
    530                 535                 540                 


Glu Lys Glu Val Ser Ile Phe Leu Gln Leu Arg Asn Leu Asn Asp Asn 
545                 550                 555                 560 


Gln Pro Met Phe Glu Glu Val Asn Cys Thr Gly Ser Ile Arg Gln Asp 
                565                 570                 575     


Trp Pro Val Gly Lys Ser Ile Met Thr Met Ser Ala Ile Asp Val Asp 
            580                 585                 590         


Glu Leu Gln Asn Leu Lys Tyr Glu Ile Val Ser Gly Asn Glu Leu Glu 
        595                 600                 605             


Tyr Phe Asp Leu Asn His Phe Ser Gly Val Ile Ser Leu Lys Arg Pro 
    610                 615                 620                 


Phe Ile Asn Leu Thr Ala Gly Gln Pro Thr Ser Tyr Ser Leu Lys Ile 
625                 630                 635                 640 


Thr Ala Ser Asp Gly Lys Asn Tyr Ala Ser Pro Thr Thr Leu Asn Ile 
                645                 650                 655     


Thr Val Val Lys Asp Pro His Phe Glu Val Pro Val Thr Cys Asp Lys 
            660                 665                 670         


Thr Gly Val Leu Thr Gln Phe Thr Lys Thr Ile Leu His Phe Ile Gly 
        675                 680                 685             


Leu Gln Asn Gln Glu Ser Ser Asp Glu Glu Phe Thr Ser Leu Ser Thr 
    690                 695                 700                 


Tyr Gln Ile Asn His Tyr Thr Pro Gln Phe Glu Asp His Phe Pro Gln 
705                 710                 715                 720 


Ser Ile Asp Val Leu Glu Ser Val Pro Ile Asn Thr Pro Leu Ala Arg 
                725                 730                 735     


Leu Ala Ala Thr Asp Pro Asp Ala Gly Phe Asn Gly Lys Leu Val Tyr 
            740                 745                 750         


Val Ile Ala Asp Gly Asn Glu Glu Gly Cys Phe Asp Ile Glu Leu Glu 
        755                 760                 765             


Thr Gly Leu Leu Thr Val Ala Ala Pro Leu Asp Tyr Glu Ala Thr Asn 
    770                 775                 780                 


Phe Tyr Ile Leu Asn Val Thr Val Tyr Asp Leu Gly Thr Pro Gln Lys 
785                 790                 795                 800 


Ser Ser Trp Lys Leu Leu Thr Val Asn Val Lys Asp Trp Asn Asp Asn 
                805                 810                 815     


Ala Pro Arg Phe Pro Pro Gly Gly Tyr Gln Leu Thr Ile Ser Glu Asp 
            820                 825                 830         


Thr Glu Val Gly Thr Thr Ile Ala Glu Leu Thr Thr Lys Asp Ala Asp 
        835                 840                 845             


Ser Glu Asp Asn Gly Arg Val Arg Tyr Thr Leu Leu Ser Pro Thr Glu 
    850                 855                 860                 


Lys Phe Ser Leu His Pro Leu Thr Gly Glu Leu Val Val Thr Gly His 
865                 870                 875                 880 


Leu Asp Arg Glu Ser Glu Pro Arg Tyr Ile Leu Lys Val Glu Ala Arg 
                885                 890                 895     


Asp Gln Pro Ser Lys Gly His Gln Leu Phe Ser Val Thr Asp Leu Ile 
            900                 905                 910         


Ile Thr Leu Glu Asp Val Asn Asp Asn Ser Pro Gln Cys Ile Thr Glu 
        915                 920                 925             


His Asn Arg Leu Lys Val Pro Glu Asp Leu Pro Pro Gly Thr Val Leu 
    930                 935                 940                 


Thr Phe Leu Asp Ala Ser Asp Pro Asp Leu Gly Pro Ala Gly Glu Val 
945                 950                 955                 960 


Arg Tyr Val Leu Met Asp Gly Ala His Gly Thr Phe Arg Val Asp Leu 
                965                 970                 975     


Met Thr Gly Ala Leu Ile Leu Glu Arg Glu Leu Asp Phe Glu Arg Arg 
            980                 985                 990         


Ala Gly Tyr Asn Leu Ser Leu Trp  Ala Ser Asp Gly Gly  Arg Pro Leu 
        995                 1000                 1005             


Ala Arg  Arg Thr Leu Cys His  Val Glu Val Ile Val  Leu Asp Val 
    1010                 1015                 1020             


Asn Glu  Asn Leu His Pro Pro  His Phe Ala Ser Phe  Val His Gln 
    1025                 1030                 1035             


Gly Gln  Val Gln Glu Asn Ser  Pro Ser Gly Thr Gln  Val Ile Val 
    1040                 1045                 1050             


Val Ala  Ala Gln Asp Asp Asp  Ser Gly Leu Asp Gly  Glu Leu Gln 
    1055                 1060                 1065             


Tyr Phe  Leu Arg Ala Gly Thr  Gly Leu Ala Ala Phe  Ser Ile Asn 
    1070                 1075                 1080             


Gln Asp  Thr Gly Met Ile Gln  Thr Leu Ala Pro Leu  Asp Arg Glu 
    1085                 1090                 1095             


Phe Ala  Ser Tyr Tyr Trp Leu  Thr Val Leu Ala Val  Asp Arg Gly 
    1100                 1105                 1110             


Ser Val  Pro Leu Ser Ser Val  Thr Glu Val Tyr Ile  Glu Val Thr 
    1115                 1120                 1125             


Asp Ala  Asn Asp Asn Pro Pro  Gln Met Ser Gln Ala  Val Phe Tyr 
    1130                 1135                 1140             


Pro Ser  Ile Gln Glu Asp Ala  Pro Val Gly Thr Ser  Val Leu Gln 
    1145                 1150                 1155             


Leu Asp  Ala Trp Asp Pro Asp  Ser Ser Ser Lys Gly  Lys Leu Thr 
    1160                 1165                 1170             


Phe Asn  Ile Thr Ser Gly Asn  Tyr Met Gly Phe Phe  Met Ile His 
    1175                 1180                 1185             


Pro Val  Thr Gly Leu Leu Ser  Thr Ala Gln Gln Leu  Asp Arg Glu 
    1190                 1195                 1200             


Asn Lys  Asp Glu His Ile Leu  Glu Val Thr Val Leu  Asp Asn Gly 
    1205                 1210                 1215             


Glu Pro  Ser Leu Lys Ser Thr  Ser Arg Val Val Val  Gly Ile Leu 
    1220                 1225                 1230             


Asp Val  Asn Asp Asn Pro Pro  Ile Phe Ser His Lys  Leu Phe Asn 
    1235                 1240                 1245             


Val Arg  Leu Pro Glu Arg Leu  Ser Pro Val Ser Pro  Gly Pro Val 
    1250                 1255                 1260             


Tyr Arg  Leu Val Ala Ser Asp  Leu Asp Glu Gly Leu  Asn Gly Arg 
    1265                 1270                 1275             


Val Thr  Tyr Ser Ile Glu Asp  Ser Asp Glu Glu Ala  Phe Ser Ile 
    1280                 1285                 1290             


Asp Leu  Val Thr Gly Val Val  Ser Ser Ser Ser Thr  Phe Thr Ala 
    1295                 1300                 1305             


Gly Glu  Tyr Asn Ile Leu Thr  Ile Lys Ala Thr Asp  Ser Gly Gln 
    1310                 1315                 1320             


Pro Pro  Leu Ser Ala Ser Val  Arg Leu His Ile Glu  Trp Ile Pro 
    1325                 1330                 1335             


Trp Pro  Arg Pro Ser Ser Ile  Pro Leu Ala Phe Asp  Glu Thr Tyr 
    1340                 1345                 1350             


Tyr Ser  Phe Thr Val Met Glu  Thr Asp Pro Val Asn  His Met Val 
    1355                 1360                 1365             


Gly Val  Ile Ser Val Glu Gly  Arg Pro Gly Leu Phe  Trp Phe Asn 
    1370                 1375                 1380             


Ile Ser  Gly Gly Asp Lys Asp  Met Asp Phe Asp Ile  Glu Lys Thr 
    1385                 1390                 1395             


Thr Gly  Ser Ile Val Ile Ala  Arg Pro Leu Asp Thr  Arg Arg Arg 
    1400                 1405                 1410             


Ser Asn  Tyr Asn Leu Thr Val  Glu Val Thr Asp Gly  Ser Arg Thr 
    1415                 1420                 1425             


Ile Ala  Thr Gln Val His Ile  Phe Met Ile Ala Asn  Ile Asn His 
    1430                 1435                 1440             


His Arg  Pro Gln Phe Leu Glu  Thr Arg Tyr Glu Val  Arg Val Pro 
    1445                 1450                 1455             


Gln Asp  Thr Val Pro Gly Val  Glu Leu Leu Arg Val  Gln Ala Ile 
    1460                 1465                 1470             


Asp Gln  Asp Lys Gly Lys Ser  Leu Ile Tyr Thr Ile  His Gly Ser 
    1475                 1480                 1485             


Gln Asp  Pro Gly Ser Ala Ser  Leu Phe Gln Leu Asp  Pro Ser Ser 
    1490                 1495                 1500             


Gly Val  Leu Val Thr Val Gly  Lys Leu Asp Leu Gly  Ser Gly Pro 
    1505                 1510                 1515             


Ser Gln  His Thr Leu Thr Val  Met Val Arg Asp Gln  Glu Ile Pro 
    1520                 1525                 1530             


Ile Lys  Arg Asn Phe Val Trp  Val Thr Ile His Val  Glu Asp Gly 
    1535                 1540                 1545             


Asn Leu  His Pro Pro Arg Phe  Thr Gln Leu His Tyr  Glu Ala Ser 
    1550                 1555                 1560             


Val Pro  Asp Thr Ile Ala Pro  Gly Thr Glu Leu Leu  Gln Val Arg 
    1565                 1570                 1575             


Ala Met  Asp Ala Asp Arg Gly  Val Asn Ala Glu Val  His Tyr Ser 
    1580                 1585                 1590             


Leu Leu  Lys Gly Asn Ser Glu  Gly Phe Phe Asn Ile  Asn Ala Leu 
    1595                 1600                 1605             


Leu Gly  Ile Ile Thr Leu Ala  Gln Lys Leu Asp Gln  Ala Asn His 
    1610                 1615                 1620             


Ala Pro  His Thr Leu Thr Val  Lys Ala Glu Asp Gln  Gly Ser Pro 
    1625                 1630                 1635             


Gln Trp  His Asp Leu Ala Thr  Val Ile Ile His Val  Tyr Pro Ser 
    1640                 1645                 1650             


Asp Arg  Ser Ala Pro Ile Phe  Ser Lys Ser Glu Tyr  Phe Val Glu 
    1655                 1660                 1665             


Ile Pro  Glu Ser Ile Pro Val  Gly Ser Pro Ile Leu  Leu Val Ser 
    1670                 1675                 1680             


Ala Met  Ser Pro Ser Glu Val  Thr Tyr Glu Leu Arg  Glu Gly Asn 
    1685                 1690                 1695             


Lys Asp  Gly Val Phe Ser Met  Asn Ser Tyr Ser Gly  Leu Ile Ser 
    1700                 1705                 1710             


Thr Gln  Lys Lys Leu Asp His  Glu Lys Ile Ser Ser  Tyr Gln Leu 
    1715                 1720                 1725             


Lys Ile  Arg Gly Ser Asn Met  Ala Gly Ala Phe Thr  Asp Val Met 
    1730                 1735                 1740             


Val Val  Val Asp Ile Ile Asp  Glu Asn Asp Asn Ala  Pro Met Phe 
    1745                 1750                 1755             


Leu Lys  Ser Thr Phe Val Gly  Gln Ile Ser Glu Ala  Ala Pro Leu 
    1760                 1765                 1770             


Tyr Ser  Met Ile Met Asp Lys  Asn Asn Asn Pro Phe  Val Ile His 
    1775                 1780                 1785             


Ala Ser  Asp Ser Asp Lys Glu  Ala Asn Ser Leu Leu  Val Tyr Lys 
    1790                 1795                 1800             


Ile Leu  Glu Pro Glu Ala Leu  Lys Phe Phe Lys Ile  Asp Pro Ser 
    1805                 1810                 1815             


Met Gly  Thr Leu Thr Ile Val  Ser Glu Met Asp Tyr  Glu Ser Met 
    1820                 1825                 1830             


Pro Ser  Phe Gln Phe Cys Val  Tyr Val His Asp Gln  Gly Ser Pro 
    1835                 1840                 1845             


Val Leu  Phe Ala Pro Arg Pro  Ala Gln Val Ile Ile  His Val Arg 
    1850                 1855                 1860             


Asp Val  Asn Asp Ser Pro Pro  Arg Phe Ser Glu Gln  Ile Tyr Glu 
    1865                 1870                 1875             


Val Ala  Ile Val Gly Pro Ile  His Pro Gly Met Glu  Leu Leu Met 
    1880                 1885                 1890             


Val Arg  Ala Ser Asp Glu Asp  Ser Glu Val Asn Tyr  Ser Ile Lys 
    1895                 1900                 1905             


Thr Gly  Asn Ala Asp Glu Ala  Val Thr Ile His Pro  Val Thr Gly 
    1910                 1915                 1920             


Ser Ile  Ser Val Leu Asn Pro  Ala Phe Leu Gly Leu  Ser Arg Lys 
    1925                 1930                 1935             


Leu Thr  Ile Arg Ala Ser Asp  Gly Leu Tyr Gln Asp  Thr Ala Leu 
    1940                 1945                 1950             


Val Lys  Ile Ser Leu Thr Gln  Val Leu Asp Lys Ser  Leu Gln Phe 
    1955                 1960                 1965             


Asp Gln  Asp Val Tyr Trp Ala  Ala Val Lys Glu Asn  Leu Gln Asp 
    1970                 1975                 1980             


Arg Lys  Ala Leu Val Ile Leu  Gly Ala Gln Gly Asn  His Leu Asn 
    1985                 1990                 1995             


Asp Thr  Leu Ser Tyr Phe Leu  Leu Asn Gly Thr Asp  Met Phe His 
    2000                 2005                 2010             


Met Val  Gln Ser Ala Gly Val  Leu Gln Thr Arg Gly  Val Ala Phe 
    2015                 2020                 2025             


Asp Arg  Glu Gln Gln Asp Thr  His Glu Leu Ala Val  Glu Val Arg 
    2030                 2035                 2040             


Asp Asn  Arg Thr Pro Gln Arg  Val Ala Gln Gly Leu  Val Arg Val 
    2045                 2050                 2055             


Ser Ile  Glu Asp Val Asn Asp  Asn Pro Pro Lys Phe  Lys His Leu 
    2060                 2065                 2070             


Pro Tyr  Tyr Thr Ile Ile Gln  Asp Gly Thr Glu Pro  Gly Asp Val 
    2075                 2080                 2085             


Leu Phe  Gln Val Ser Ala Thr  Asp Glu Asp Leu Gly  Thr Asn Gly 
    2090                 2095                 2100             


Ala Val  Thr Tyr Glu Phe Ala  Glu Asp Tyr Thr Tyr  Phe Arg Ile 
    2105                 2110                 2115             


Asp Pro  Tyr Leu Gly Asp Ile  Ser Leu Lys Lys Pro  Phe Asp Tyr 
    2120                 2125                 2130             


Gln Ala  Leu Asn Lys Tyr His  Leu Lys Val Ile Ala  Arg Asp Gly 
    2135                 2140                 2145             


Gly Thr  Pro Ser Leu Gln Ser  Glu Glu Glu Val Leu  Val Thr Val 
    2150                 2155                 2160             


Arg Asn  Lys Ser Asn Pro Leu  Phe Gln Ser Pro Tyr  Tyr Lys Val 
    2165                 2170                 2175             


Arg Val  Pro Glu Asn Ile Thr  Leu Tyr Thr Pro Ile  Leu His Thr 
    2180                 2185                 2190             


Gln Ala  Arg Ser Pro Glu Gly  Leu Arg Leu Ile Tyr  Asn Ile Val 
    2195                 2200                 2205             


Glu Glu  Glu Pro Leu Met Leu  Phe Thr Thr Asp Phe  Lys Thr Gly 
    2210                 2215                 2220             


Val Leu  Thr Val Thr Gly Pro  Leu Asp Tyr Glu Ser  Lys Thr Lys 
    2225                 2230                 2235             


His Val  Phe Thr Val Arg Ala  Thr Asp Thr Ala Leu  Gly Ser Phe 
    2240                 2245                 2250             


Ser Glu  Ala Thr Val Glu Val  Leu Val Glu Asp Val  Asn Asp Asn 
    2255                 2260                 2265             


Pro Pro  Thr Phe Ser Gln Leu  Val Tyr Thr Thr Ser  Ile Ser Glu 
    2270                 2275                 2280             


Gly Leu  Pro Ala Gln Thr Pro  Val Ile Gln Leu Leu  Ala Ser Asp 
    2285                 2290                 2295             


Gln Asp  Ser Gly Arg Asn Arg  Asp Val Ser Tyr Gln  Ile Val Glu 
    2300                 2305                 2310             


Asp Gly  Ser Asp Val Ser Lys  Phe Phe Gln Ile Asn  Gly Ser Thr 
    2315                 2320                 2325             


Gly Glu  Met Ser Thr Val Gln  Glu Leu Asp Tyr Glu  Ala Gln Gln 
    2330                 2335                 2340             


His Phe  His Val Lys Val Arg  Ala Met Asp Lys Gly  Asp Pro Pro 
    2345                 2350                 2355             


Leu Thr  Gly Glu Thr Leu Val  Val Val Asn Val Ser  Asp Ile Asn 
    2360                 2365                 2370             


Asp Asn  Pro Pro Glu Phe Arg  Gln Pro Gln Tyr Glu  Ala Asn Val 
    2375                 2380                 2385             


Ser Glu  Leu Ala Thr Cys Gly  His Leu Val Leu Lys  Val Gln Ala 
    2390                 2395                 2400             


Ile Asp  Pro Asp Ser Arg Asp  Thr Ser Arg Leu Glu  Tyr Leu Ile 
    2405                 2410                 2415             


Leu Ser  Gly Asn Gln Asp Arg  His Phe Phe Ile Asn  Ser Ser Ser 
    2420                 2425                 2430             


Gly Ile  Ile Ser Met Phe Asn  Leu Cys Lys Lys His  Leu Asp Ser 
    2435                 2440                 2445             


Ser Tyr  Asn Leu Arg Val Gly  Ala Ser Asp Gly Val  Phe Arg Ala 
    2450                 2455                 2460             


Thr Val  Pro Val Tyr Ile Asn  Thr Thr Asn Ala Asn  Lys Tyr Ser 
    2465                 2470                 2475             


Pro Glu  Phe Gln Gln His Leu  Tyr Glu Ala Glu Leu  Ala Glu Asn 
    2480                 2485                 2490             


Ala Met  Val Gly Thr Lys Val  Ile Asp Leu Leu Ala  Ile Asp Lys 
    2495                 2500                 2505             


Asp Ser  Gly Pro Tyr Gly Thr  Ile Asp Tyr Thr Ile  Ile Asn Lys 
    2510                 2515                 2520             


Leu Ala  Ser Glu Lys Phe Ser  Ile Asn Pro Asn Gly  Gln Ile Ala 
    2525                 2530                 2535             


Thr Leu  Gln Lys Leu Asp Arg  Glu Asn Ser Thr Glu  Arg Val Ile 
    2540                 2545                 2550             


Ala Ile  Lys Val Met Ala Arg  Asp Gly Gly Gly Arg  Val Ala Phe 
    2555                 2560                 2565             


Cys Thr  Val Lys Ile Ile Leu  Thr Asp Glu Asn Asp  Asn Pro Pro 
    2570                 2575                 2580             


Gln Phe  Lys Ala Ser Glu Tyr  Thr Val Ser Ile Gln  Ser Asn Val 
    2585                 2590                 2595             


Ser Lys  Asp Ser Pro Val Ile  Gln Val Leu Ala Tyr  Asp Ala Asp 
    2600                 2605                 2610             


Glu Gly  Gln Asn Ala Asp Val  Thr Tyr Ser Val Asn  Pro Glu Asp 
    2615                 2620                 2625             


Leu Val  Lys Asp Val Ile Glu  Ile Asn Pro Val Thr  Gly Val Val 
    2630                 2635                 2640             


Lys Val  Lys Asp Ser Leu Val  Gly Leu Glu Asn Gln  Thr Leu Asp 
    2645                 2650                 2655             


Phe Phe  Ile Lys Ala Gln Asp  Gly Gly Pro Pro His  Trp Asn Ser 
    2660                 2665                 2670             


Leu Val  Pro Val Arg Leu Gln  Val Val Pro Lys Lys  Val Ser Leu 
    2675                 2680                 2685             


Pro Lys  Phe Ser Glu Pro Leu  Tyr Thr Phe Ser Ala  Pro Glu Asp 
    2690                 2695                 2700             


Leu Pro  Glu Gly Ser Glu Ile  Gly Ile Val Lys Ala  Val Ala Ala 
    2705                 2710                 2715             


Gln Asp  Pro Val Ile Tyr Ser  Leu Val Arg Gly Thr  Thr Pro Glu 
    2720                 2725                 2730             


Ser Asn  Lys Asp Gly Val Phe  Ser Leu Asp Pro Asp  Thr Gly Val 
    2735                 2740                 2745             


Ile Lys  Val Arg Lys Pro Met  Asp His Glu Ser Thr  Lys Leu Tyr 
    2750                 2755                 2760             


Gln Ile  Asp Val Met Ala His  Cys Leu Gln Asn Thr  Asp Val Val 
    2765                 2770                 2775             


Ser Leu  Val Ser Val Asn Ile  Gln Val Gly Asp Val  Asn Asp Asn 
    2780                 2785                 2790             


Arg Pro  Val Phe Glu Ala Asp  Pro Tyr Lys Ala Val  Leu Thr Glu 
    2795                 2800                 2805             


Asn Met  Pro Val Gly Thr Ser  Val Ile Gln Val Thr  Ala Ile Asp 
    2810                 2815                 2820             


Lys Asp  Thr Gly Arg Asp Gly  Gln Val Ser Tyr Arg  Leu Ser Ala 
    2825                 2830                 2835             


Asp Pro  Gly Ser Asn Val His  Glu Leu Phe Ala Ile  Asp Ser Glu 
    2840                 2845                 2850             


Ser Gly  Trp Ile Thr Thr Leu  Gln Glu Leu Asp Cys  Glu Thr Cys 
    2855                 2860                 2865             


Gln Thr  Tyr His Phe His Val  Val Ala Tyr Asp His  Gly Gln Thr 
    2870                 2875                 2880             


Ile Gln  Leu Ser Ser Gln Ala  Leu Val Gln Val Ser  Ile Thr Asp 
    2885                 2890                 2895             


Glu Asn  Asp Asn Ala Pro Arg  Phe Ala Ser Glu Glu  Tyr Arg Gly 
    2900                 2905                 2910             


Ser Val  Val Glu Asn Ser Glu  Pro Gly Glu Leu Val  Ala Thr Leu 
    2915                 2920                 2925             


Lys Thr  Leu Asp Ala Asp Ile  Ser Glu Gln Asn Arg  Gln Val Thr 
    2930                 2935                 2940             


Cys Tyr  Ile Thr Glu Gly Asp  Pro Leu Gly Gln Phe  Gly Ile Ser 
    2945                 2950                 2955             


Gln Val  Gly Asp Glu Trp Arg  Ile Ser Ser Arg Lys  Thr Leu Asp 
    2960                 2965                 2970             


Arg Glu  His Thr Ala Lys Tyr  Leu Leu Arg Val Thr  Ala Ser Asp 
    2975                 2980                 2985             


Gly Lys  Phe Gln Ala Ser Val  Thr Val Glu Ile Phe  Val Leu Asp 
    2990                 2995                 3000             


Val Asn  Asp Asn Ser Pro Gln  Cys Ser Gln Leu Leu  Tyr Thr Gly 
    3005                 3010                 3015             


Lys Val  His Glu Asp Val Phe  Pro Gly His Phe Ile  Leu Lys Val 
    3020                 3025                 3030             


Ser Ala  Thr Asp Leu Asp Thr  Asp Thr Asn Ala Gln  Ile Thr Tyr 
    3035                 3040                 3045             


Ser Leu  His Gly Pro Gly Ala  His Glu Phe Lys Leu  Asp Pro His 
    3050                 3055                 3060             


Thr Gly  Glu Leu Thr Thr Leu  Thr Ala Leu Asp Arg  Glu Arg Lys 
    3065                 3070                 3075             


Asp Val  Phe Asn Leu Val Ala  Lys Ala Thr Asp Gly  Gly Gly Arg 
    3080                 3085                 3090             


Ser Cys  Gln Ala Asp Ile Thr  Leu His Val Glu Asp  Val Asn Asp 
    3095                 3100                 3105             


Asn Ala  Pro Arg Phe Phe Pro  Ser His Cys Ala Val  Ala Val Phe 
    3110                 3115                 3120             


Asp Asn  Thr Thr Val Lys Thr  Pro Val Ala Val Val  Phe Ala Arg 
    3125                 3130                 3135             


Asp Pro  Asp Gln Gly Ala Asn  Ala Gln Val Val Tyr  Ser Leu Pro 
    3140                 3145                 3150             


Asp Ser  Ala Glu Gly His Phe  Ser Ile Asp Ala Thr  Thr Gly Val 
    3155                 3160                 3165             


Ile Arg  Leu Glu Lys Pro Leu  Gln Val Arg Pro Gln  Ala Pro Leu 
    3170                 3175                 3180             


Glu Leu  Thr Val Arg Ala Ser  Asp Leu Gly Thr Pro  Ile Pro Leu 
    3185                 3190                 3195             


Ser Thr  Leu Gly Thr Val Thr  Val Ser Val Val Gly  Leu Glu Asp 
    3200                 3205                 3210             


Tyr Leu  Pro Val Phe Leu Asn  Thr Glu His Ser Val  Gln Val Pro 
    3215                 3220                 3225             


Glu Asp  Ala Pro Pro Gly Thr  Glu Val Leu Gln Leu  Ala Thr Leu 
    3230                 3235                 3240             


Thr Arg  Pro Gly Ala Glu Lys  Thr Gly Tyr Arg Val  Val Ser Gly 
    3245                 3250                 3255             


Asn Glu  Gln Gly Arg Phe Arg  Leu Asp Ala Arg Thr  Gly Ile Leu 
    3260                 3265                 3270             


Tyr Val  Asn Ala Ser Leu Asp  Phe Glu Thr Ser Pro  Lys Tyr Phe 
    3275                 3280                 3285             


Leu Ser  Ile Glu Cys Ser Arg  Lys Ser Ser Ser Ser  Leu Ser Asp 
    3290                 3295                 3300             


Val Thr  Thr Val Met Val Asn  Ile Thr Asp Val Asn  Glu His Arg 
    3305                 3310                 3315             


Pro Gln  Phe Pro Gln Asp Pro  Tyr Ser Thr Arg Val  Leu Glu Asn 
    3320                 3325                 3330             


Ala Leu  Val Gly Asp Val Ile  Leu Thr Val Ser Ala  Thr Asp Glu 
    3335                 3340                 3345             


Asp Gly  Pro Leu Asn Ser Asp  Ile Thr Tyr Ser Leu  Ile Gly Gly 
    3350                 3355                 3360             


Asn Gln  Leu Gly His Phe Thr  Ile His Pro Lys Lys  Gly Glu Leu 
    3365                 3370                 3375             


Gln Val  Ala Lys Ala Leu Asp  Arg Glu Gln Ala Ser  Ser Tyr Ser 
    3380                 3385                 3390             


Leu Lys  Leu Arg Ala Thr Asp  Ser Gly Gln Pro Pro  Leu His Glu 
    3395                 3400                 3405             


Asp Thr  Asp Ile Ala Ile Gln  Val Ala Asp Val Asn  Asp Asn Pro 
    3410                 3415                 3420             


Pro Arg  Phe Phe Gln Leu Asn  Tyr Ser Thr Thr Val  Gln Glu Asn 
    3425                 3430                 3435             


Ser Pro  Ile Gly Ser Lys Val  Leu Gln Leu Ile Leu  Ser Asp Pro 
    3440                 3445                 3450             


Asp Ser  Pro Glu Asn Gly Pro  Pro Tyr Ser Phe Arg  Ile Thr Lys 
    3455                 3460                 3465             


Gly Asn  Asn Gly Ser Ala Phe  Arg Val Thr Pro Asp  Gly Trp Leu 
    3470                 3475                 3480             


Val Thr  Ala Glu Gly Leu Ser  Arg Arg Ala Gln Glu  Trp Tyr Gln 
    3485                 3490                 3495             


Leu Gln  Ile Gln Ala Ser Asp  Ser Gly Ile Pro Pro  Leu Ser Ser 
    3500                 3505                 3510             


Leu Thr  Ser Val Arg Val His  Val Thr Glu Gln Ser  His Tyr Ala 
    3515                 3520                 3525             


Pro Ser  Ala Leu Pro Leu Glu  Ile Phe Ile Thr Val  Gly Glu Asp 
    3530                 3535                 3540             


Glu Phe  Gln Gly Gly Met Val  Gly Lys Ile His Ala  Thr Asp Arg 
    3545                 3550                 3555             


Asp Pro  Gln Asp Thr Leu Thr  Tyr Ser Leu Ala Glu  Glu Glu Thr 
    3560                 3565                 3570             


Leu Gly  Arg His Phe Ser Val  Gly Ala Pro Asp Gly  Lys Ile Ile 
    3575                 3580                 3585             


Ala Ala  Gln Gly Leu Pro Arg  Gly His Tyr Ser Phe  Asn Val Thr 
    3590                 3595                 3600             


Val Ser  Asp Gly Thr Phe Thr  Thr Thr Ala Gly Val  His Val Tyr 
    3605                 3610                 3615             


Val Trp  His Val Gly Gln Glu  Ala Leu Gln Gln Ala  Met Trp Met 
    3620                 3625                 3630             


Gly Phe  Tyr Gln Leu Thr Pro  Glu Glu Leu Val Ser  Asp His Trp 
    3635                 3640                 3645             


Arg Asn  Leu Gln Arg Phe Leu  Ser His Lys Leu Asp  Ile Lys Arg 
    3650                 3655                 3660             


Ala Asn  Ile His Leu Ala Ser  Leu Gln Pro Ala Glu  Ala Val Ala 
    3665                 3670                 3675             


Gly Val  Asp Val Leu Leu Val  Phe Glu Gly His Ser  Gly Thr Phe 
    3680                 3685                 3690             


Tyr Glu  Phe Gln Glu Leu Ala  Ser Ile Ile Thr His  Ser Ala Lys 
    3695                 3700                 3705             


Glu Met  Glu His Ser Val Gly  Val Gln Met Arg Ser  Ala Met Pro 
    3710                 3715                 3720             


Met Val  Pro Cys Gln Gly Pro  Thr Cys Gln Gly Gln  Ile Cys His 
    3725                 3730                 3735             


Asn Thr  Val His Leu Asp Pro  Lys Val Gly Pro Thr  Tyr Ser Thr 
    3740                 3745                 3750             


Ala Arg  Leu Ser Ile Leu Thr  Pro Arg His His Leu  Gln Arg Ser 
    3755                 3760                 3765             


Cys Ser  Cys Asn Gly Thr Ala  Thr Arg Phe Ser Gly  Gln Ser Tyr 
    3770                 3775                 3780             


Val Arg  Tyr Arg Ala Pro Ala  Ala Arg Asn Trp His  Ile His Phe 
    3785                 3790                 3795             


Tyr Leu  Lys Thr Leu Gln Pro  Gln Ala Ile Leu Leu  Phe Thr Asn 
    3800                 3805                 3810             


Glu Thr  Ala Ser Val Ser Leu  Lys Leu Ala Ser Gly  Val Pro Gln 
    3815                 3820                 3825             


Leu Glu  Tyr His Cys Leu Gly  Gly Phe Tyr Gly Asn  Leu Ser Ser 
    3830                 3835                 3840             


Gln Arg  His Val Asn Asp His  Glu Trp His Ser Ile  Leu Val Glu 
    3845                 3850                 3855             


Glu Met  Asp Ala Ser Ile Arg  Leu Met Val Asp Ser  Met Gly Asn 
    3860                 3865                 3870             


Thr Ser  Leu Val Val Pro Glu  Asn Cys Arg Gly Leu  Arg Pro Glu 
    3875                 3880                 3885             


Arg His  Leu Leu Leu Gly Gly  Leu Ile Leu Leu His  Ser Ser Ser 
    3890                 3895                 3900             


Asn Val  Ser Gln Gly Phe Glu  Gly Cys Leu Asp Ala  Val Val Val 
    3905                 3910                 3915             


Asn Glu  Glu Ala Leu Asp Leu  Leu Ala Pro Gly Lys  Thr Val Ala 
    3920                 3925                 3930             


Gly Leu  Leu Glu Thr Gln Ala  Leu Thr Gln Cys Cys  Leu His Ser 
    3935                 3940                 3945             


Asp Tyr  Cys Ser Gln Asn Thr  Cys Leu Asn Gly Gly  Lys Cys Ser 
    3950                 3955                 3960             


Trp Thr  His Gly Ala Gly Tyr  Val Cys Lys Cys Pro  Pro Gln Phe 
    3965                 3970                 3975             


Ser Gly  Lys His Cys Glu Gln  Gly Arg Glu Asn Cys  Thr Phe Ala 
    3980                 3985                 3990             


Pro Cys  Leu Glu Gly Gly Thr  Cys Ile Leu Ser Pro  Lys Gly Ala 
    3995                 4000                 4005             


Ser Cys  Asn Cys Pro His Pro  Tyr Thr Gly Asp Arg  Cys Glu Met 
    4010                 4015                 4020             


Glu Ala  Arg Gly Cys Ser Glu  Gly His Cys Leu Val  Thr Pro Glu 
    4025                 4030                 4035             


Ile Gln  Arg Gly Asp Trp Gly  Gln Gln Glu Leu Leu  Ile Ile Thr 
    4040                 4045                 4050             


Val Ala  Val Ala Phe Ile Ile  Ile Ser Thr Val Gly  Leu Leu Phe 
    4055                 4060                 4065             


Tyr Cys  Arg Arg Cys Lys Ser  His Lys Pro Val Ala  Met Glu Asp 
    4070                 4075                 4080             


Pro Asp  Leu Leu Ala Arg Ser  Val Gly Val Asp Thr  Gln Ala Met 
    4085                 4090                 4095             


Pro Ala  Ile Glu Leu Asn Pro  Leu Ser Ala Ser Ser  Cys Asn Asn 
    4100                 4105                 4110             


Leu Asn  Gln Pro Glu Pro Ser  Lys Ala Ser Val Pro  Asn Glu Leu 
    4115                 4120                 4125             


Val Thr  Phe Gly Pro Asn Ser  Lys Gln Arg Pro Val  Val Cys Ser 
    4130                 4135                 4140             


Val Pro  Pro Arg Leu Pro Pro  Ala Ala Val Pro Ser  His Ser Asp 
    4145                 4150                 4155             


Asn Glu  Pro Val Ile Lys Arg  Thr Trp Ser Ser Glu  Glu Met Val 
    4160                 4165                 4170             


Tyr Pro  Gly Gly Ala Met Val  Trp Pro Pro Thr Tyr  Ser Arg Asn 
    4175                 4180                 4185             


Glu Arg  Trp Glu Tyr Pro His  Ser Glu Val Thr Gln  Gly Pro Leu 
    4190                 4195                 4200             


Pro Pro  Ser Ala His Arg His  Ser Thr Pro Val Val  Met Pro Glu 
    4205                 4210                 4215             


Pro Asn  Gly Leu Tyr Gly Gly  Phe Pro Phe Pro Leu  Glu Met Glu 
    4220                 4225                 4230             


Asn Lys  Arg Ala Pro Leu Pro  Pro Arg Tyr Ser Asn  Gln Asn Leu 
    4235                 4240                 4245             


Glu Asp  Leu Met Pro Ser Arg  Pro Pro Ser Pro Arg  Glu Arg Leu 
    4250                 4255                 4260             


Val Ala  Pro Cys Leu Asn Glu  Tyr Thr Ala Ile Ser  Tyr Tyr His 
    4265                 4270                 4275             


Ser Gln  Phe Arg Gln Gly Gly  Gly Gly Pro Cys Leu  Ala Asp Gly 
    4280                 4285                 4290             


Gly Tyr  Lys Gly Val Gly Met  Arg Leu Ser Arg Ala  Gly Pro Ser 
    4295                 4300                 4305             


Tyr Ala  Val Cys Glu Val Glu  Gly Ala Pro Leu Ala  Gly Gln Gly 
    4310                 4315                 4320             


Gln Pro  Arg Val Pro Pro Asn  Tyr Glu Gly Ser Asp  Met Val Glu 
    4325                 4330                 4335             


Ser Asp  Tyr Gly Ser Cys Glu  Glu Val Met Phe 
    4340                 4345                 


<210>  3906
<211>  4557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAT3__Homo_sapiens__NP_001008781

<400>  3906

Met Asp Ile Ile Met Gly His Cys Val Gly Thr Arg Pro Pro Ala Cys 
1               5                   10                  15      


Cys Leu Ile Leu Leu Leu Phe Lys Leu Leu Ala Thr Val Ser Gln Gly 
            20                  25                  30          


Leu Pro Gly Thr Gly Pro Leu Gly Phe His Phe Thr His Ser Ile Tyr 
        35                  40                  45              


Asn Ala Thr Val Tyr Glu Asn Ser Ala Ala Arg Thr Tyr Val Asn Ser 
    50                  55                  60                  


Gln Ser Arg Met Gly Ile Thr Leu Ile Asp Leu Ser Trp Asp Ile Lys 
65                  70                  75                  80  


Tyr Arg Ile Val Ser Gly Asp Glu Glu Gly Phe Phe Lys Ala Glu Glu 
                85                  90                  95      


Val Ile Ile Ala Asp Phe Cys Phe Leu Arg Ile Arg Thr Lys Gly Gly 
            100                 105                 110         


Asn Ser Ala Ile Leu Asn Arg Glu Ile Gln Asp Asn Tyr Leu Leu Ile 
        115                 120                 125             


Val Lys Gly Ser Val Arg Gly Glu Asp Leu Glu Ala Trp Thr Lys Val 
    130                 135                 140                 


Asn Ile Gln Val Leu Asp Met Asn Asp Leu Arg Pro Leu Phe Ser Pro 
145                 150                 155                 160 


Thr Thr Tyr Ser Val Thr Ile Ala Glu Ser Thr Pro Leu Arg Thr Ser 
                165                 170                 175     


Val Ala Gln Val Thr Ala Thr Asp Ala Asp Ile Gly Ser Asn Gly Glu 
            180                 185                 190         


Phe Tyr Tyr Tyr Phe Lys Asn Lys Val Asp Leu Phe Ser Val His Pro 
        195                 200                 205             


Thr Ser Gly Val Ile Ser Leu Ser Gly Arg Leu Asn Tyr Asp Glu Lys 
    210                 215                 220                 


Asn Arg Tyr Asp Leu Glu Ile Leu Ala Val Asp Arg Gly Met Lys Leu 
225                 230                 235                 240 


Tyr Gly Asn Asn Gly Val Ser Ser Thr Ala Lys Leu Tyr Val His Ile 
                245                 250                 255     


Glu Arg Ile Asn Glu His Ala Pro Thr Ile His Val Val Thr His Val 
            260                 265                 270         


Pro Phe Ser Leu Glu Lys Glu Pro Thr Tyr Ala Val Val Thr Val Asp 
        275                 280                 285             


Asp Leu Asp Asp Gly Ala Asn Gly Glu Ile Glu Ser Val Ser Ile Val 
    290                 295                 300                 


Ala Gly Asp Pro Leu Asp Gln Phe Phe Leu Ala Lys Glu Gly Lys Trp 
305                 310                 315                 320 


Leu Asn Glu Tyr Lys Ile Lys Glu Arg Lys Gln Ile Asp Trp Glu Ser 
                325                 330                 335     


Phe Pro Tyr Gly Tyr Asn Leu Thr Leu Gln Ala Lys Asp Lys Gly Ser 
            340                 345                 350         


Pro Gln Lys Cys Ser Ala Leu Lys Ala Val Tyr Ile Gly Asn Pro Thr 
        355                 360                 365             


Arg Asp Thr Val Pro Ile Arg Phe Glu Lys Glu Val Tyr Asp Val Ser 
    370                 375                 380                 


Ile Ser Glu Phe Ser Pro Pro Gly Val Val Val Ala Ile Val Lys Leu 
385                 390                 395                 400 


Ser Pro Glu Pro Ile Asp Val Glu Tyr Lys Leu Ser Pro Gly Glu Asp 
                405                 410                 415     


Ala Val Tyr Phe Lys Ile Asn Pro Arg Ser Gly Leu Ile Val Thr Ala 
            420                 425                 430         


Arg Pro Leu Asn Thr Val Lys Lys Glu Val Tyr Lys Leu Glu Val Thr 
        435                 440                 445             


Asn Lys Glu Gly Asp Leu Lys Ala Gln Val Thr Ile Ser Ile Glu Asp 
    450                 455                 460                 


Ala Asn Asp His Thr Pro Glu Phe Gln Gln Pro Leu Tyr Asp Ala Tyr 
465                 470                 475                 480 


Val Asn Glu Ser Val Pro Val Gly Thr Ser Val Leu Thr Val Ser Ala 
                485                 490                 495     


Ser Asp Lys Asp Lys Gly Glu Asn Gly Tyr Ile Thr Tyr Ser Ile Ala 
            500                 505                 510         


Ser Leu Asn Leu Leu Pro Phe Val Ile Asn Gln Phe Thr Gly Val Ile 
        515                 520                 525             


Ser Thr Thr Glu Glu Leu Asp Phe Glu Ser Ser Pro Glu Ile Tyr Arg 
    530                 535                 540                 


Phe Ile Val Arg Ala Ser Asp Trp Gly Ser Pro Tyr Arg His Glu Ser 
545                 550                 555                 560 


Glu Val Asn Val Thr Ile Arg Ile Gly Asn Val Asn Asp Asn Ser Pro 
                565                 570                 575     


Leu Phe Glu Lys Val Ala Cys Gln Gly Val Ile Ser Tyr Asp Phe Pro 
            580                 585                 590         


Val Gly Gly His Ile Thr Ala Val Ser Ala Ile Asp Ile Asp Glu Leu 
        595                 600                 605             


Glu Leu Val Lys Tyr Lys Ile Ile Ser Gly Asn Glu Leu Gly Phe Phe 
    610                 615                 620                 


Tyr Leu Asn Pro Asp Ser Gly Val Leu Gln Leu Lys Lys Ser Leu Thr 
625                 630                 635                 640 


Asn Ser Gly Ile Lys Asn Gly Asn Phe Ala Leu Arg Ile Thr Ala Thr 
                645                 650                 655     


Asp Gly Glu Asn Leu Ala Asp Pro Met Ser Ile Asn Ile Ser Val Leu 
            660                 665                 670         


His Gly Lys Val Ser Ser Lys Ser Phe Ser Cys Arg Glu Thr Arg Val 
        675                 680                 685             


Ala Gln Lys Leu Ala Glu Lys Leu Leu Ile Lys Ala Lys Ala Asn Gly 
    690                 695                 700                 


Lys Leu Asn Leu Glu Asp Gly Phe Leu Asp Phe Tyr Ser Ile Asn Arg 
705                 710                 715                 720 


Gln Gly Pro Tyr Phe Asp Lys Ser Phe Pro Ser Asp Val Ala Val Lys 
                725                 730                 735     


Glu Asp Leu Pro Val Gly Ala Asn Ile Leu Lys Ile Lys Ala Tyr Asp 
            740                 745                 750         


Ala Asp Ser Gly Phe Asn Gly Lys Val Leu Phe Thr Ile Ser Asp Gly 
        755                 760                 765             


Asn Thr Asp Ser Cys Phe Asn Ile Asp Met Glu Thr Gly Gln Leu Lys 
    770                 775                 780                 


Val Leu Met Pro Met Asp Arg Glu His Thr Asp Leu Tyr Leu Leu Asn 
785                 790                 795                 800 


Ile Thr Ile Tyr Asp Leu Gly Asn Pro Gln Lys Ser Ser Trp Arg Leu 
                805                 810                 815     


Leu Thr Ile Asn Val Glu Asp Ala Asn Asp Asn Ser Pro Val Phe Ile 
            820                 825                 830         


Gln Asp Ser Tyr Ser Val Asn Ile Leu Glu Ser Ser Gly Ile Gly Thr 
        835                 840                 845             


Glu Ile Ile Gln Val Glu Ala Arg Asp Lys Asp Leu Gly Ser Asn Gly 
    850                 855                 860                 


Glu Val Thr Tyr Ser Val Leu Thr Asp Thr Gln Gln Phe Ala Ile Asn 
865                 870                 875                 880 


Ser Ser Thr Gly Ile Val Tyr Val Ala Asp Gln Leu Asp Arg Glu Ser 
                885                 890                 895     


Lys Ala Asn Tyr Ser Leu Lys Ile Glu Ala Arg Asp Lys Ala Glu Ser 
            900                 905                 910         


Gly Gln Gln Leu Phe Ser Val Val Thr Leu Lys Val Phe Leu Asp Asp 
        915                 920                 925             


Val Asn Asp Cys Ser Pro Ala Phe Ile Pro Ser Ser Tyr Ser Val Lys 
    930                 935                 940                 


Val Leu Glu Asp Leu Pro Val Gly Thr Val Ile Ala Trp Leu Glu Thr 
945                 950                 955                 960 


His Asp Pro Asp Leu Gly Leu Gly Gly Gln Val Arg Tyr Ser Leu Val 
                965                 970                 975     


Asn Asp Tyr Asn Gly Arg Phe Glu Ile Asp Lys Ala Ser Gly Ala Ile 
            980                 985                 990         


Arg Leu Ser Lys Glu Leu Asp Tyr  Glu Lys Gln Gln Phe  Tyr Asn Leu 
        995                 1000                 1005             


Thr Val  Arg Ala Lys Asp Lys  Gly Arg Pro Val Ser  Leu Ser Ser 
    1010                 1015                 1020             


Val Ser  Phe Val Glu Val Glu  Val Val Asp Val Asn  Glu Asn Leu 
    1025                 1030                 1035             


His Thr  Pro Tyr Phe Pro Asp  Phe Ala Val Val Gly  Ser Val Lys 
    1040                 1045                 1050             


Glu Asn  Ser Arg Ile Gly Thr  Ser Val Leu Gln Val  Thr Ala Arg 
    1055                 1060                 1065             


Asp Glu  Asp Ser Gly Arg Asp  Gly Glu Ile Gln Tyr  Ser Ile Arg 
    1070                 1075                 1080             


Asp Gly  Ser Gly Leu Gly Arg  Phe Ser Ile Asp Asp  Glu Ser Gly 
    1085                 1090                 1095             


Val Ile  Thr Ala Ala Asp Ile  Leu Asp Arg Glu Thr  Met Gly Ser 
    1100                 1105                 1110             


Tyr Trp  Leu Thr Val Tyr Ala  Thr Asp Arg Gly Val  Val Pro Leu 
    1115                 1120                 1125             


Tyr Ser  Thr Ile Glu Val Tyr  Ile Glu Val Glu Asp  Val Asn Asp 
    1130                 1135                 1140             


Asn Ala  Pro Leu Thr Ser Glu  Pro Ile Tyr Tyr Pro  Val Val Met 
    1145                 1150                 1155             


Glu Asn  Ser Pro Lys Asp Val  Ser Val Ile Gln Ile  Gln Ala Glu 
    1160                 1165                 1170             


Asp Pro  Asp Ser Ser Ser Asn  Glu Lys Leu Thr Tyr  Arg Ile Thr 
    1175                 1180                 1185             


Ser Gly  Asn Pro Gln Asn Phe  Phe Ala Ile Asn Ile  Lys Thr Gly 
    1190                 1195                 1200             


Leu Ile  Thr Thr Thr Ser Arg  Lys Leu Asp Arg Glu  Gln Gln Ala 
    1205                 1210                 1215             


Glu His  Phe Leu Glu Val Thr  Val Thr Asp Gly Gly  Pro Ser Pro 
    1220                 1225                 1230             


Lys Gln  Ser Thr Ile Trp Val  Val Val Gln Val Leu  Asp Glu Asn 
    1235                 1240                 1245             


Asp Asn  Lys Pro Gln Phe Pro  Glu Lys Val Tyr Gln  Ile Lys Leu 
    1250                 1255                 1260             


Pro Glu  Arg Asp Arg Lys Lys  Arg Gly Glu Pro Ile  Tyr Arg Ala 
    1265                 1270                 1275             


Phe Ala  Phe Asp Arg Asp Glu  Gly Pro Asn Ala Glu  Ile Ser Tyr 
    1280                 1285                 1290             


Ser Ile  Val Asp Gly Asn Asp  Asp Gly Lys Phe Phe  Ile Asp Pro 
    1295                 1300                 1305             


Lys Thr  Gly Met Val Ser Ser  Arg Lys Gln Phe Thr  Ala Gly Ser 
    1310                 1315                 1320             


Tyr Asp  Ile Leu Thr Ile Lys  Ala Val Asp Asn Gly  Arg Pro Gln 
    1325                 1330                 1335             


Lys Ser  Ser Thr Ala Arg Leu  His Ile Glu Trp Ile  Lys Lys Pro 
    1340                 1345                 1350             


Pro Pro  Ser Pro Ile Pro Leu  Thr Phe Asp Glu Pro  Phe Tyr Asn 
    1355                 1360                 1365             


Phe Thr  Val Met Glu Ser Asp  Arg Val Thr Glu Ile  Val Gly Val 
    1370                 1375                 1380             


Val Ser  Val Gln Pro Ala Asn  Thr Pro Leu Trp Phe  Asp Ile Val 
    1385                 1390                 1395             


Gly Gly  Asn Phe Asp Ser Ala  Phe Asp Ala Glu Lys  Gly Val Gly 
    1400                 1405                 1410             


Thr Ile  Val Ile Ala Lys Pro  Leu Asp Ala Glu Gln  Arg Ser Ile 
    1415                 1420                 1425             


Tyr Asn  Met Ser Val Glu Val  Thr Asp Gly Thr Asn  Val Ala Val 
    1430                 1435                 1440             


Thr Gln  Val Phe Ile Lys Val  Leu Asp Asn Asn Asp  Asn Gly Pro 
    1445                 1450                 1455             


Glu Phe  Ser Gln Pro Asn Tyr  Asp Val Thr Ile Ser  Glu Asp Val 
    1460                 1465                 1470             


Leu Pro  Asp Thr Glu Ile Leu  Gln Ile Glu Ala Thr  Asp Arg Asp 
    1475                 1480                 1485             


Glu Lys  His Lys Leu Ser Tyr  Thr Val His Ser Ser  Ile Asp Ser 
    1490                 1495                 1500             


Ile Ser  Met Arg Lys Phe Arg  Ile Asp Pro Ser Thr  Gly Val Leu 
    1505                 1510                 1515             


Tyr Thr  Ala Glu Arg Leu Asp  His Glu Ala Gln Asp  Lys His Ile 
    1520                 1525                 1530             


Leu Asn  Ile Met Val Arg Asp  Gln Glu Phe Pro Tyr  Arg Arg Asn 
    1535                 1540                 1545             


Leu Ala  Arg Val Ile Val Asn  Val Glu Asp Ala Asn  Asp His Ser 
    1550                 1555                 1560             


Pro Tyr  Phe Thr Asn Pro Leu  Tyr Glu Ala Ser Val  Phe Glu Ser 
    1565                 1570                 1575             


Ala Ala  Leu Gly Ser Ala Val  Leu Gln Val Thr Ala  Leu Asp Lys 
    1580                 1585                 1590             


Asp Lys  Gly Glu Asn Ala Glu  Leu Ile Tyr Thr Ile  Glu Ala Gly 
    1595                 1600                 1605             


Asn Thr  Gly Asn Met Phe Lys  Ile Glu Pro Val Leu  Gly Ile Ile 
    1610                 1615                 1620             


Thr Ile  Cys Lys Glu Pro Asp  Met Thr Thr Met Gly  Gln Phe Val 
    1625                 1630                 1635             


Leu Ser  Ile Lys Val Thr Asp  Gln Gly Ser Pro Pro  Met Ser Ala 
    1640                 1645                 1650             


Thr Ala  Ile Val Arg Ile Ser  Val Thr Met Ser Asp  Asn Ser His 
    1655                 1660                 1665             


Pro Lys  Phe Ile His Lys Asp  Tyr Gln Ala Glu Val  Asn Glu Asn 
    1670                 1675                 1680             


Val Asp  Ile Gly Thr Ser Val  Ile Leu Ile Ser Ala  Ile Ser Gln 
    1685                 1690                 1695             


Ser Thr  Leu Ile Tyr Glu Val  Lys Asp Gly Asp Ile  Asn Gly Ile 
    1700                 1705                 1710             


Phe Thr  Ile Asn Pro Tyr Ser  Gly Val Ile Thr Thr  Gln Lys Ala 
    1715                 1720                 1725             


Leu Asp  Tyr Glu Arg Thr Ser  Ser Tyr Gln Leu Ile  Ile Gln Ala 
    1730                 1735                 1740             


Thr Asn  Met Ala Gly Met Ala  Ser Asn Ala Thr Val  Asn Ile Gln 
    1745                 1750                 1755             


Ile Val  Asp Glu Asn Asp Asn  Ala Pro Val Phe Leu  Phe Ser Gln 
    1760                 1765                 1770             


Tyr Ser  Gly Ser Leu Ser Glu  Ala Ala Pro Ile Asn  Ser Ile Val 
    1775                 1780                 1785             


Arg Ser  Leu Asp Asn Ser Pro  Leu Val Ile Arg Ala  Thr Asp Ala 
    1790                 1795                 1800             


Asp Ser  Asn Arg Asn Ala Leu  Leu Val Tyr Gln Ile  Val Glu Ser 
    1805                 1810                 1815             


Thr Ala  Lys Lys Phe Phe Thr  Val Asp Ser Ser Thr  Gly Ala Ile 
    1820                 1825                 1830             


Arg Thr  Ile Ala Asn Leu Asp  His Glu Thr Ile Ala  His Phe His 
    1835                 1840                 1845             


Phe His  Val His Val Arg Asp  Ser Gly Ser Pro Gln  Leu Thr Ala 
    1850                 1855                 1860             


Glu Ser  Pro Val Glu Val Asn  Ile Glu Val Thr Asp  Val Asn Asp 
    1865                 1870                 1875             


Asn Pro  Pro Val Phe Thr Gln  Ala Val Phe Glu Thr  Ile Leu Leu 
    1880                 1885                 1890             


Leu Pro  Thr Tyr Val Gly Val  Glu Val Leu Lys Val  Ser Ala Thr 
    1895                 1900                 1905             


Asp Pro  Asp Ser Glu Val Pro  Pro Glu Leu Thr Tyr  Ser Leu Met 
    1910                 1915                 1920             


Glu Gly  Ser Leu Asp His Phe  Leu Ile Asp Ser Asn  Ser Gly Val 
    1925                 1930                 1935             


Leu Thr  Ile Lys Asn Asn Asn  Leu Ser Lys Asp His  Tyr Met Leu 
    1940                 1945                 1950             


Ile Val  Lys Val Ser Asp Gly  Lys Phe Tyr Ser Thr  Ser Met Val 
    1955                 1960                 1965             


Thr Ile  Met Val Lys Glu Ala  Met Asp Ser Gly Leu  His Phe Thr 
    1970                 1975                 1980             


Gln Ser  Phe Tyr Ser Thr Ser  Ile Ser Glu Asn Asn  Thr Asn Ile 
    1985                 1990                 1995             


Thr Lys  Val Ala Ile Val Asn  Ala Val Gly Asn Arg  Leu Asn Glu 
    2000                 2005                 2010             


Pro Leu  Lys Tyr Ser Ile Leu  Asn Pro Gly Asn Lys  Phe Lys Ile 
    2015                 2020                 2025             


Lys Ser  Thr Ser Gly Val Ile  Gln Thr Thr Gly Val  Pro Phe Asp 
    2030                 2035                 2040             


Arg Glu  Glu Gln Glu Leu Tyr  Glu Leu Val Val Glu  Ala Ser Arg 
    2045                 2050                 2055             


Glu Leu  Asp His Leu Arg Val  Ala Arg Val Val Val  Arg Val Asn 
    2060                 2065                 2070             


Ile Glu  Asp Ile Asn Asp Asn  Ser Pro Val Phe Val  Gly Leu Pro 
    2075                 2080                 2085             


Tyr Tyr  Ala Ala Val Gln Val  Asp Ala Glu Pro Gly  Thr Leu Ile 
    2090                 2095                 2100             


Tyr Gln  Val Thr Ala Ile Asp  Lys Asp Lys Gly Pro  Asn Gly Glu 
    2105                 2110                 2115             


Val Thr  Tyr Val Leu Gln Asp  Asp Tyr Gly His Phe  Glu Ile Asn 
    2120                 2125                 2130             


Pro Asn  Ser Gly Asn Val Ile  Leu Lys Glu Ala Phe  Asn Ser Asp 
    2135                 2140                 2145             


Leu Ser  Asn Ile Glu Tyr Gly  Val Thr Ile Leu Ala  Lys Asp Gly 
    2150                 2155                 2160             


Gly Lys  Pro Ser Leu Ser Thr  Ser Val Glu Leu Pro  Ile Thr Ile 
    2165                 2170                 2175             


Val Asn  Lys Ala Met Pro Val  Phe Asp Lys Pro Phe  Tyr Thr Ala 
    2180                 2185                 2190             


Ser Val  Asn Glu Asp Ile Arg  Met Asn Thr Pro Ile  Leu Ser Ile 
    2195                 2200                 2205             


Asn Ala  Thr Ser Pro Glu Gly  Gln Gly Ile Ile Tyr  Ile Ile Ile 
    2210                 2215                 2220             


Asp Gly  Asp Pro Phe Lys Gln  Phe Asn Ile Asp Phe  Asp Thr Gly 
    2225                 2230                 2235             


Val Leu  Lys Val Val Ser Pro  Leu Asp Tyr Glu Val  Thr Ser Ala 
    2240                 2245                 2250             


Tyr Lys  Leu Thr Ile Arg Ala  Ser Asp Ala Leu Thr  Gly Ala Arg 
    2255                 2260                 2265             


Ala Glu  Val Thr Val Asp Leu  Leu Val Asn Asp Val  Asn Asp Asn 
    2270                 2275                 2280             


Pro Pro  Ile Phe Asp Gln Pro  Thr Tyr Asn Thr Thr  Leu Ser Glu 
    2285                 2290                 2295             


Ala Ser  Leu Ile Gly Thr Pro  Val Leu Gln Val Val  Ser Ile Asp 
    2300                 2305                 2310             


Ala Asp  Ser Glu Asn Asn Lys  Met Val His Tyr Gln  Ile Val Gln 
    2315                 2320                 2325             


Asp Thr  Tyr Asn Ser Thr Asp  Tyr Phe His Ile Asp  Ser Ser Ser 
    2330                 2335                 2340             


Gly Leu  Ile Leu Thr Ala Arg  Met Leu Asp His Glu  Leu Val Gln 
    2345                 2350                 2355             


His Cys  Thr Leu Lys Val Arg  Ser Ile Asp Ser Gly  Phe Pro Ser 
    2360                 2365                 2370             


Leu Ser  Ser Glu Val Leu Val  His Ile Tyr Ile Ser  Asp Val Asn 
    2375                 2380                 2385             


Asp Asn  Pro Pro Val Phe Asn  Gln Leu Ile Tyr Glu  Ser Tyr Val 
    2390                 2395                 2400             


Ser Glu  Leu Ala Pro Arg Gly  His Phe Val Thr Cys  Val Gln Ala 
    2405                 2410                 2415             


Ser Asp  Ala Asp Ser Ser Asp  Phe Asp Arg Leu Glu  Tyr Ser Ile 
    2420                 2425                 2430             


Leu Ser  Gly Asn Asp Arg Thr  Ser Phe Leu Met Asp  Ser Lys Ser 
    2435                 2440                 2445             


Gly Val  Ile Thr Leu Ser Asn  His Arg Lys Gln Arg  Met Glu Pro 
    2450                 2455                 2460             


Leu Tyr  Ser Leu Asn Val Ser  Val Ser Asp Gly Leu  Phe Thr Ser 
    2465                 2470                 2475             


Thr Ala  Gln Val His Ile Arg  Val Leu Gly Ala Asn  Leu Tyr Ser 
    2480                 2485                 2490             


Pro Ala  Phe Ser Gln Ser Thr  Tyr Val Ala Glu Val  Arg Glu Asn 
    2495                 2500                 2505             


Val Ala  Ala Gly Thr Lys Val  Ile His Val Arg Ala  Thr Asp Gly 
    2510                 2515                 2520             


Asp Pro  Gly Thr Tyr Gly Gln  Ile Ser Tyr Ala Ile  Ile Asn Asp 
    2525                 2530                 2535             


Phe Ala  Lys Asp Arg Phe Leu  Ile Asp Ser Asn Gly  Gln Val Ile 
    2540                 2545                 2550             


Thr Thr  Glu Arg Leu Asp Arg  Glu Asn Pro Leu Glu  Gly Asp Val 
    2555                 2560                 2565             


Ser Ile  Phe Val Arg Ala Leu  Asp Gly Gly Gly Arg  Thr Thr Phe 
    2570                 2575                 2580             


Cys Thr  Val Arg Val Ile Val  Val Asp Glu Asn Asp  Asn Ala Pro 
    2585                 2590                 2595             


Gln Phe  Met Thr Val Glu Tyr  Arg Ala Ser Val Arg  Ala Asp Val 
    2600                 2605                 2610             


Gly Arg  Gly His Leu Val Thr  Gln Val Gln Ala Ile  Asp Pro Asp 
    2615                 2620                 2625             


Asp Gly  Ala Asn Ser Arg Ile  Thr Tyr Ser Leu Tyr  Ser Glu Ala 
    2630                 2635                 2640             


Ser Val  Ser Val Ala Asp Leu  Leu Glu Ile Asp Pro  Asp Asn Gly 
    2645                 2650                 2655             


Trp Met  Val Thr Lys Gly Asn  Phe Asn Gln Leu Lys  Asn Thr Val 
    2660                 2665                 2670             


Leu Ser  Phe Phe Val Lys Ala  Val Asp Gly Gly Ile  Pro Val Lys 
    2675                 2680                 2685             


His Ser  Leu Ile Pro Val Tyr  Ile His Val Leu Pro  Pro Glu Thr 
    2690                 2695                 2700             


Phe Leu  Pro Ser Phe Thr Gln  Ser Gln Tyr Ser Phe  Thr Ile Ala 
    2705                 2710                 2715             


Glu Asp  Thr Ala Ile Gly Ser  Thr Val Asp Thr Leu  Arg Ile Leu 
    2720                 2725                 2730             


Pro Ser  Gln Asn Val Trp Phe  Ser Thr Val Asn Gly  Glu Arg Pro 
    2735                 2740                 2745             


Glu Asn  Asn Lys Gly Gly Ile  Phe Val Ile Glu Gln  Glu Thr Gly 
    2750                 2755                 2760             


Thr Ile  Lys Leu Asp Lys Arg  Leu Asp Arg Glu Thr  Ser Pro Ala 
    2765                 2770                 2775             


Phe His  Phe Lys Val Ala Ala  Thr Ile Pro Leu Asp  Lys Val Asp 
    2780                 2785                 2790             


Ile Val  Phe Thr Val Asp Val  Asp Ile Lys Val Leu  Asp Leu Asn 
    2795                 2800                 2805             


Asp Asn  Lys Pro Val Phe Glu  Thr Ser Ser Tyr Asp  Thr Ile Ile 
    2810                 2815                 2820             


Met Glu  Gly Met Pro Val Gly  Thr Lys Leu Thr Gln  Val Arg Ala 
    2825                 2830                 2835             


Ile Asp  Met Asp Trp Gly Ala  Asn Gly Gln Val Thr  Tyr Ser Leu 
    2840                 2845                 2850             


His Ser  Asp Ser Gln Pro Glu  Lys Val Met Glu Ala  Phe Asn Ile 
    2855                 2860                 2865             


Asp Ser  Asn Thr Gly Trp Ile  Ser Thr Leu Lys Asp  Leu Asp His 
    2870                 2875                 2880             


Glu Thr  Asp Pro Thr Phe Thr  Phe Ser Val Val Ala  Ser Asp Leu 
    2885                 2890                 2895             


Gly Glu  Ala Phe Ser Leu Ser  Ser Thr Ala Leu Val  Ser Val Arg 
    2900                 2905                 2910             


Val Thr  Asp Ile Asn Asp Asn  Ala Pro Val Phe Ala  Gln Glu Val 
    2915                 2920                 2925             


Tyr Arg  Gly Asn Val Lys Glu  Ser Asp Pro Pro Gly  Glu Val Val 
    2930                 2935                 2940             


Ala Val  Leu Ser Thr Trp Asp  Arg Asp Thr Ser Asp  Val Asn Arg 
    2945                 2950                 2955             


Gln Val  Ser Tyr His Ile Thr  Gly Gly Asn Pro Arg  Gly Arg Phe 
    2960                 2965                 2970             


Ala Leu  Gly Leu Val Gln Ser  Glu Trp Lys Val Tyr  Val Lys Arg 
    2975                 2980                 2985             


Pro Leu  Asp Arg Glu Glu Gln  Asp Ile Tyr Phe Leu  Asn Ile Thr 
    2990                 2995                 3000             


Ala Thr  Asp Gly Leu Phe Val  Thr Gln Ala Met Val  Glu Val Ser 
    3005                 3010                 3015             


Val Ser  Asp Val Asn Asp Asn  Ser Pro Val Cys Asp  Gln Val Ala 
    3020                 3025                 3030             


Tyr Thr  Ala Leu Leu Pro Glu  Asp Ile Pro Ser Asn  Lys Ile Ile 
    3035                 3040                 3045             


Leu Lys  Val Ser Ala Lys Asp  Ala Asp Ile Gly Ser  Asn Gly Tyr 
    3050                 3055                 3060             


Ile Arg  Tyr Ser Leu Tyr Gly  Ser Gly Asn Ser Glu  Phe Phe Leu 
    3065                 3070                 3075             


Asp Pro  Glu Ser Gly Glu Leu  Lys Thr Leu Ala Leu  Leu Asp Arg 
    3080                 3085                 3090             


Glu Arg  Ile Pro Val Tyr Ser  Leu Met Ala Lys Ala  Thr Asp Gly 
    3095                 3100                 3105             


Gly Gly  Arg Phe Cys Gln Ser  Asn Ile His Leu Ile  Leu Glu Asp 
    3110                 3115                 3120             


Val Asn  Asp Asn Pro Pro Val  Phe Ser Ser Asp His  Tyr Asn Thr 
    3125                 3130                 3135             


Cys Val  Tyr Glu Asn Thr Ala  Thr Lys Ala Leu Leu  Thr Arg Val 
    3140                 3145                 3150             


Gln Ala  Val Asp Pro Asp Ile  Gly Ile Asn Arg Lys  Val Val Tyr 
    3155                 3160                 3165             


Ser Leu  Ala Asp Ser Ala Gly  Gly Val Phe Ser Ile  Asp Ser Ser 
    3170                 3175                 3180             


Ser Gly  Ile Ile Ile Leu Glu  Gln Pro Leu Asp Arg  Glu Gln Gln 
    3185                 3190                 3195             


Ser Ser  Tyr Asn Ile Ser Val  Arg Ala Thr Asp Gln  Ser Pro Gly 
    3200                 3205                 3210             


Gln Ser  Leu Ser Ser Leu Thr  Thr Val Thr Ile Thr  Val Leu Asp 
    3215                 3220                 3225             


Ile Asn  Asp Asn Pro Pro Val  Phe Glu Arg Arg Asp  Tyr Leu Val 
    3230                 3235                 3240             


Thr Val  Pro Glu Asp Thr Ser  Pro Gly Thr Gln Val  Leu Ala Val 
    3245                 3250                 3255             


Phe Ala  Thr Ser Lys Asp Ile  Gly Thr Asn Ala Glu  Ile Thr Tyr 
    3260                 3265                 3270             


Leu Ile  Arg Ser Gly Asn Glu  Gln Gly Lys Phe Lys  Ile Asn Pro 
    3275                 3280                 3285             


Lys Thr  Gly Gly Ile Ser Val  Ser Glu Val Leu Asp  Tyr Glu Leu 
    3290                 3295                 3300             


Cys Lys  Arg Phe Tyr Leu Val  Val Glu Ala Lys Asp  Gly Gly Thr 
    3305                 3310                 3315             


Pro Ala  Leu Ser Ala Val Ala  Thr Val Asn Ile Asn  Leu Thr Asp 
    3320                 3325                 3330             


Val Asn  Asp Asn Pro Pro Lys  Phe Ser Gln Asp Val  Tyr Ser Ala 
    3335                 3340                 3345             


Val Ile  Ser Glu Asp Ala Leu  Val Gly Asp Ser Val  Ile Leu Leu 
    3350                 3355                 3360             


Ile Ala  Glu Asp Val Asp Ser  Gln Pro Asn Gly Gln  Ile His Phe 
    3365                 3370                 3375             


Ser Ile  Val Asn Gly Asp Arg  Asp Asn Glu Phe Thr  Val Asp Pro 
    3380                 3385                 3390             


Val Leu  Gly Leu Val Lys Val  Lys Lys Lys Leu Asp  Arg Glu Arg 
    3395                 3400                 3405             


Val Ser  Gly Tyr Ser Leu Leu  Val Gln Ala Val Asp  Ser Gly Ile 
    3410                 3415                 3420             


Pro Ala  Met Ser Ser Thr Ala  Thr Val Asn Ile Asp  Ile Ser Asp 
    3425                 3430                 3435             


Val Asn  Asp Asn Ser Pro Val  Phe Thr Pro Ala Asn  Tyr Thr Ala 
    3440                 3445                 3450             


Val Ile  Gln Glu Asn Lys Pro  Val Gly Thr Ser Ile  Leu Gln Leu 
    3455                 3460                 3465             


Val Val  Thr Asp Arg Asp Ser  Phe His Asn Gly Pro  Pro Phe Ser 
    3470                 3475                 3480             


Phe Ser  Ile Leu Ser Gly Asn  Glu Glu Glu Glu Phe  Val Leu Asp 
    3485                 3490                 3495             


Pro His  Gly Ile Leu Arg Ser  Ala Val Val Phe Gln  His Thr Glu 
    3500                 3505                 3510             


Ser Leu  Glu Tyr Val Leu Cys  Val Gln Ala Lys Asp  Ser Gly Lys 
    3515                 3520                 3525             


Pro Gln  Gln Val Ser His Thr  Tyr Ile Arg Val Arg  Val Ile Glu 
    3530                 3535                 3540             


Glu Ser  Thr His Lys Pro Thr  Ala Ile Pro Leu Glu  Ile Phe Ile 
    3545                 3550                 3555             


Val Thr  Met Glu Asp Asp Phe  Pro Gly Gly Val Ile  Gly Lys Ile 
    3560                 3565                 3570             


His Ala  Thr Asp Gln Asp Met  Tyr Asp Val Leu Thr  Phe Ala Leu 
    3575                 3580                 3585             


Lys Ser  Glu Gln Lys Ser Leu  Phe Lys Val Asn Ser  His Asp Gly 
    3590                 3595                 3600             


Lys Ile  Ile Ala Leu Gly Gly  Leu Asp Ser Gly Lys  Tyr Val Leu 
    3605                 3610                 3615             


Asn Val  Ser Val Ser Asp Gly  Arg Phe Gln Val Pro  Ile Asp Val 
    3620                 3625                 3630             


Val Val  His Val Glu Gln Leu  Val His Glu Met Leu  Gln Asn Thr 
    3635                 3640                 3645             


Val Thr  Ile Arg Phe Glu Asn  Val Ser Pro Glu Asp  Phe Val Gly 
    3650                 3655                 3660             


Leu His  Met His Gly Phe Arg  Arg Thr Leu Arg Asn  Ala Val Leu 
    3665                 3670                 3675             


Thr Gln  Lys Gln Asp Ser Leu  Arg Ile Ile Ser Ile  Gln Pro Val 
    3680                 3685                 3690             


Ala Gly  Thr Asn Gln Leu Asp  Met Leu Phe Ala Val  Glu Met His 
    3695                 3700                 3705             


Ser Ser  Glu Phe Tyr Lys Pro  Ala Tyr Leu Ile Gln  Lys Leu Ser 
    3710                 3715                 3720             


Asn Ala  Arg Arg His Leu Glu  Asn Ile Met Arg Ile  Ser Ala Ile 
    3725                 3730                 3735             


Leu Glu  Lys Asn Cys Ser Gly  Leu Asp Cys Gln Glu  Gln His Cys 
    3740                 3745                 3750             


Glu Gln  Gly Leu Ser Leu Asp  Ser His Ala Leu Met  Thr Tyr Ser 
    3755                 3760                 3765             


Thr Ala  Arg Ile Ser Phe Val  Cys Pro Arg Phe Tyr  Arg Asn Val 
    3770                 3775                 3780             


Arg Cys  Thr Cys Asn Gly Gly  Leu Cys Pro Gly Ser  Asn Asp Pro 
    3785                 3790                 3795             


Cys Val  Glu Lys Pro Cys Pro  Gly Asp Met Gln Cys  Val Ser Tyr 
    3800                 3805                 3810             


Glu Ala  Ser Arg Arg Pro Phe  Leu Cys Gln Cys Pro  Pro Gly Lys 
    3815                 3820                 3825             


Leu Gly  Glu Cys Ser Gly His  Thr Ser Leu Ser Phe  Ala Gly Asn 
    3830                 3835                 3840             


Ser Tyr  Ile Lys Tyr Arg Leu  Ser Glu Asn Ser Lys  Glu Glu Asp 
    3845                 3850                 3855             


Phe Lys  Leu Ala Leu Arg Leu  Arg Thr Leu Gln Ser  Asn Gly Ile 
    3860                 3865                 3870             


Ile Met  Tyr Thr Arg Ala Asn  Pro Cys Ile Ile Leu  Lys Ile Val 
    3875                 3880                 3885             


Asp Gly  Lys Leu Trp Phe Gln  Leu Asp Cys Gly Ser  Gly Pro Gly 
    3890                 3895                 3900             


Ile Leu  Gly Ile Ser Gly Arg  Ala Val Asn Asp Gly  Ser Trp His 
    3905                 3910                 3915             


Ser Val  Phe Leu Glu Leu Asn  Arg Asn Phe Thr Ser  Leu Ser Leu 
    3920                 3925                 3930             


Asp Asp  Ser Tyr Val Glu Arg  Arg Arg Ala Pro Leu  Tyr Phe Gln 
    3935                 3940                 3945             


Thr Leu  Ser Thr Glu Ser Ser  Ile Tyr Phe Gly Ala  Leu Val Gln 
    3950                 3955                 3960             


Ala Asp  Asn Ile Arg Ser Leu  Thr Asp Thr Arg Val  Thr Gln Val 
    3965                 3970                 3975             


Leu Ser  Gly Phe Gln Gly Cys  Leu Asp Ser Val Ile  Leu Asn Asn 
    3980                 3985                 3990             


Asn Glu  Leu Pro Leu Gln Asn  Lys Arg Ser Ser Phe  Ala Glu Val 
    3995                 4000                 4005             


Val Gly  Leu Thr Glu Leu Lys  Leu Gly Cys Val Leu  Tyr Pro Asp 
    4010                 4015                 4020             


Ala Cys  Lys Arg Ser Pro Cys  Gln His Gly Gly Ser  Cys Thr Gly 
    4025                 4030                 4035             


Leu Pro  Ser Gly Gly Tyr Gln  Cys Thr Cys Leu Ser  Gln Phe Thr 
    4040                 4045                 4050             


Gly Arg  Asn Cys Glu Ser Glu  Ile Thr Ala Cys Phe  Pro Asn Pro 
    4055                 4060                 4065             


Cys Arg  Asn Gly Gly Ser Cys  Asp Pro Ile Gly Asn  Thr Phe Ile 
    4070                 4075                 4080             


Cys Asn  Cys Lys Ala Gly Leu  Thr Gly Val Thr Cys  Glu Glu Asp 
    4085                 4090                 4095             


Ile Asn  Glu Cys Glu Arg Glu  Glu Cys Glu Asn Gly  Gly Ser Cys 
    4100                 4105                 4110             


Val Asn  Val Phe Gly Ser Phe  Leu Cys Asn Cys Thr  Pro Gly Tyr 
    4115                 4120                 4125             


Val Gly  Gln Tyr Cys Gly Leu  Arg Pro Val Val Val  Pro Asn Ile 
    4130                 4135                 4140             


Gln Ala  Gly His Ser Tyr Val  Gly Lys Glu Glu Leu  Ile Gly Ile 
    4145                 4150                 4155             


Ala Val  Val Leu Phe Val Ile  Phe Ile Leu Val Val  Leu Phe Ile 
    4160                 4165                 4170             


Val Phe  Arg Lys Lys Val Phe  Arg Lys Asn Tyr Ser  Arg Asn Asn 
    4175                 4180                 4185             


Ile Thr  Leu Val Gln Asp Pro  Ala Thr Ala Ala Leu  Leu Asn Lys 
    4190                 4195                 4200             


Ser Asn  Gly Ile Pro Phe Arg  Asn Leu Arg Gly Ser  Gly Asp Gly 
    4205                 4210                 4215             


Arg Asn  Val Tyr Gln Glu Val  Gly Pro Pro Gln Val  Pro Val Arg 
    4220                 4225                 4230             


Pro Met  Ala Tyr Thr Pro Cys  Phe Gln Ser Asp Ser  Arg Ser Asn 
    4235                 4240                 4245             


Leu Asp  Lys Ile Val Asp Gly  Leu Gly Gly Glu His  Gln Glu Met 
    4250                 4255                 4260             


Thr Thr  Phe His Pro Glu Ser  Pro Arg Ile Leu Thr  Ala Arg Arg 
    4265                 4270                 4275             


Gly Val  Val Val Cys Ser Val  Ala Pro Asn Leu Pro  Ala Val Ser 
    4280                 4285                 4290             


Pro Cys  Arg Ser Asp Cys Asp  Ser Ile Arg Lys Asn  Gly Trp Asp 
    4295                 4300                 4305             


Ala Gly  Thr Glu Asn Lys Gly  Val Asp Asp Pro Gly  Glu Val Thr 
    4310                 4315                 4320             


Cys Phe  Ala Gly Ser Asn Lys  Gly Ser Asn Ser Glu  Val Gln Ser 
    4325                 4330                 4335             


Leu Ser  Ser Phe Gln Ser Asp  Ser Gly Asp Asp Asn  Ala Tyr His 
    4340                 4345                 4350             


Trp Asp  Thr Ser Asp Trp Met  Pro Gly Ala Arg Leu  Ser Asp Ile 
    4355                 4360                 4365             


Glu Glu  Val Pro Asn Tyr Glu  Asn Gln Asp Gly Gly  Ser Ala His 
    4370                 4375                 4380             


Gln Gly  Ser Thr Arg Glu Leu  Glu Ser Asp Tyr Tyr  Leu Gly Gly 
    4385                 4390                 4395             


Tyr Asp  Ile Asp Ser Glu Tyr  Pro Pro Pro His Glu  Glu Glu Phe 
    4400                 4405                 4410             


Leu Ser  Gln Asp Gln Leu Pro  Pro Pro Leu Pro Glu  Asp Phe Pro 
    4415                 4420                 4425             


Asp Gln  Tyr Glu Ala Leu Pro  Pro Ser Gln Pro Val  Ser Leu Ala 
    4430                 4435                 4440             


Ser Thr  Leu Ser Pro Asp Cys  Arg Arg Arg Pro Gln  Phe His Pro 
    4445                 4450                 4455             


Ser Gln  Tyr Leu Pro Pro His  Pro Phe Pro Asn Glu  Thr Asp Leu 
    4460                 4465                 4470             


Val Gly  Pro Pro Ala Ser Cys  Glu Phe Ser Thr Phe  Ala Val Ser 
    4475                 4480                 4485             


Met Asn  Gln Gly Thr Glu Pro  Thr Gly Pro Ala Asp  Ser Val Ser 
    4490                 4495                 4500             


Leu Ser  Leu His Asn Ser Arg  Gly Thr Ser Ser Ser  Asp Val Ser 
    4505                 4510                 4515             


Ala Asn  Cys Gly Phe Asp Asp  Ser Glu Val Ala Met  Ser Asp Tyr 
    4520                 4525                 4530             


Glu Ser  Val Gly Glu Leu Ser  Leu Ala Ser Leu His  Ile Pro Phe 
    4535                 4540                 4545             


Val Glu  Thr Gln His Gln Thr  Gln Val 
    4550                 4555         


<210>  3907
<211>  4981
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAT4__Homo_sapiens__NP_078858

<400>  3907

Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp Leu Pro Leu 
1               5                   10                  15      


His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp Leu Leu Ser 
            20                  25                  30          


Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro Arg Gln Val 
        35                  40                  45              


Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile 
    50                  55                  60                  


Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu 
65                  70                  75                  80  


Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ser Thr Ile 
                85                  90                  95      


Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val Val Leu Ser 
            100                 105                 110         


Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu 
        115                 120                 125             


Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe 
    130                 135                 140                 


Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr 
145                 150                 155                 160 


Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile 
                165                 170                 175     


Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn 
            180                 185                 190         


Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu 
        195                 200                 205             


Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp 
    210                 215                 220                 


Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val 
225                 230                 235                 240 


Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln 
                245                 250                 255     


Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val 
            260                 265                 270         


Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg 
        275                 280                 285             


Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu 
    290                 295                 300                 


Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser 
305                 310                 315                 320 


Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu Thr Gly Arg 
                325                 330                 335     


Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val 
            340                 345                 350         


Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp 
        355                 360                 365             


Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp 
    370                 375                 380                 


Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly 
385                 390                 395                 400 


Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys Val Pro Asn 
                405                 410                 415     


Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro 
            420                 425                 430         


Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly Ala Pro Pro 
        435                 440                 445             


Gly Ala Ala Val Gln Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe 
    450                 455                 460                 


Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln Gln Val Tyr 
465                 470                 475                 480 


Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr Val Ser Gly 
                485                 490                 495     


Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr 
            500                 505                 510         


Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His 
        515                 520                 525             


Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp Arg Glu Leu 
    530                 535                 540                 


Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His 
545                 550                 555                 560 


Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu Asp Val Asn 
                565                 570                 575     


Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp Val Ser Val 
            580                 585                 590         


Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu Arg Ala Thr 
        595                 600                 605             


Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu 
    610                 615                 620                 


Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val Ser Gly Arg 
625                 630                 635                 640 


Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Ser 
                645                 650                 655     


Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Met 
            660                 665                 670         


Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val 
        675                 680                 685             


Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn Glu Pro Gly 
    690                 695                 700                 


Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp Leu Gly Thr 
705                 710                 715                 720 


Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe 
                725                 730                 735     


Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met Ala Leu Asp 
            740                 745                 750         


Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala Thr Asp Gly 
        755                 760                 765             


Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile Thr Val Leu 
    770                 775                 780                 


Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala Tyr Ser Phe 
785                 790                 795                 800 


Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser 
                805                 810                 815     


Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu Ile Thr Thr 
            820                 825                 830         


Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr Gly Gln Leu 
        835                 840                 845             


Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr Met Val Asn 
865                 870                 875                 880 


Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe Leu Gln Ala 
                885                 890                 895     


Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly His Ser Ile 
            900                 905                 910         


Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Met Val 
        915                 920                 925             


Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala Ile Asn Glu 
    930                 935                 940                 


Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val His Ala Gly 
945                 950                 955                 960 


Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val Pro Gln Leu 
                965                 970                 975     


Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val Asn Asp Asn 
            980                 985                 990         


Ser Pro Val Phe Asp Gln Leu Ser  Tyr Glu Val Thr Leu  Ser Glu Ser 
        995                 1000                 1005             


Glu Pro  Val Asn Ser Arg Phe  Phe Lys Val Gln Ala  Ser Asp Lys 
    1010                 1015                 1020             


Asp Ser  Gly Ala Asn Gly Glu  Ile Ala Tyr Thr Ile  Ala Glu Gly 
    1025                 1030                 1035             


Asn Thr  Gly Asp Ala Phe Gly  Ile Phe Pro Asp Gly  Gln Leu Tyr 
    1040                 1045                 1050             


Ile Lys  Ser Glu Leu Asp Arg  Glu Leu Gln Asp Arg  Tyr Val Leu 
    1055                 1060                 1065             


Met Val  Val Ala Ser Asp Arg  Ala Val Glu Pro Leu  Ser Ala Thr 
    1070                 1075                 1080             


Val Asn  Val Thr Val Ile Leu  Glu Asp Val Asn Asp  Asn Arg Pro 
    1085                 1090                 1095             


Leu Phe  Asn Ser Thr Asn Tyr  Thr Phe Tyr Phe Glu  Glu Glu Gln 
    1100                 1105                 1110             


Arg Ala  Gly Ser Phe Val Gly  Lys Val Ser Ala Val  Asp Lys Asp 
    1115                 1120                 1125             


Phe Gly  Pro Asn Gly Glu Val  Arg Tyr Ser Phe Glu  Met Val Gln 
    1130                 1135                 1140             


Pro Asp  Phe Glu Leu His Ala  Ile Ser Gly Glu Ile  Thr Asn Thr 
    1145                 1150                 1155             


His Gln  Phe Asp Arg Glu Ser  Leu Met Arg Arg Arg  Gly Thr Ala 
    1160                 1165                 1170             


Val Phe  Ser Phe Thr Val Ile  Ala Thr Asp Gln Gly  Ile Pro Gln 
    1175                 1180                 1185             


Pro Leu  Lys Asp Gln Ala Thr  Val His Val Tyr Met  Lys Asp Ile 
    1190                 1195                 1200             


Asn Asp  Asn Ala Pro Lys Phe  Leu Lys Asp Phe Tyr  Gln Ala Thr 
    1205                 1210                 1215             


Ile Ser  Glu Ser Ala Ala Asn  Leu Thr Gln Val Leu  Arg Val Ser 
    1220                 1225                 1230             


Ala Ser  Asp Val Asp Glu Gly  Asn Asn Gly Leu Ile  His Tyr Ser 
    1235                 1240                 1245             


Ile Ile  Lys Gly Asn Glu Glu  Arg Gln Phe Ala Ile  Asp Ser Thr 
    1250                 1255                 1260             


Ser Gly  Gln Val Thr Leu Ile  Gly Lys Leu Asp Tyr  Glu Ala Thr 
    1265                 1270                 1275             


Pro Ala  Tyr Ser Leu Val Ile  Gln Ala Val Asp Ser  Gly Thr Ile 
    1280                 1285                 1290             


Pro Leu  Asn Ser Thr Cys Thr  Leu Asn Ile Asp Ile  Leu Asp Glu 
    1295                 1300                 1305             


Asn Asp  Asn Thr Pro Ser Phe  Pro Lys Ser Thr Leu  Phe Val Asp 
    1310                 1315                 1320             


Val Leu  Glu Asn Met Arg Ile  Gly Glu Leu Val Ser  Ser Val Thr 
    1325                 1330                 1335             


Ala Thr  Asp Ser Asp Ser Gly  Asp Asn Ala Asp Leu  Tyr Tyr Ser 
    1340                 1345                 1350             


Ile Thr  Gly Thr Asn Asn His  Gly Thr Phe Ser Ile  Ser Pro Asn 
    1355                 1360                 1365             


Thr Gly  Ser Ile Phe Leu Ala  Lys Lys Leu Asp Phe  Glu Thr Gln 
    1370                 1375                 1380             


Ser Leu  Tyr Lys Leu Asn Ile  Thr Ala Lys Asp Gln  Gly Arg Pro 
    1385                 1390                 1395             


Pro Arg  Ser Ser Thr Met Ser  Val Val Ile His Val  Arg Asp Phe 
    1400                 1405                 1410             


Asn Asp  Asn Pro Pro Ser Phe  Pro Pro Gly Asp Ile  Phe Lys Ser 
    1415                 1420                 1425             


Ile Val  Glu Asn Ile Pro Ile  Gly Thr Ser Val Ile  Ser Val Thr 
    1430                 1435                 1440             


Ala His  Asp Pro Asp Ala Asp  Ile Asn Gly Gln Leu  Ser Tyr Thr 
    1445                 1450                 1455             


Ile Ile  Gln Gln Met Pro Arg  Gly Asn His Phe Thr  Ile Asp Glu 
    1460                 1465                 1470             


Val Lys  Gly Thr Ile Tyr Thr  Asn Ala Glu Ile Asp  Arg Glu Phe 
    1475                 1480                 1485             


Ala Asn  Leu Phe Glu Leu Thr  Val Lys Ala Asn Asp  Gln Ala Val 
    1490                 1495                 1500             


Pro Ile  Glu Thr Arg Arg Tyr  Ala Leu Lys Asn Val  Thr Ile Leu 
    1505                 1510                 1515             


Val Thr  Asp Leu Asn Asp Asn  Val Pro Met Phe Ile  Ser Gln Asn 
    1520                 1525                 1530             


Ala Leu  Ala Ala Asp Pro Ser  Ala Val Ile Gly Ser  Val Leu Thr 
    1535                 1540                 1545             


Thr Ile  Met Ala Ala Asp Pro  Asp Glu Gly Ala Asn  Gly Glu Ile 
    1550                 1555                 1560             


Glu Tyr  Glu Ile Ile Asn Gly  Asp Thr Asp Thr Phe  Ile Val Asp 
    1565                 1570                 1575             


Arg Tyr  Ser Gly Asp Leu Arg  Val Ala Ser Ala Leu  Val Pro Ser 
    1580                 1585                 1590             


Gln Leu  Ile Tyr Asn Leu Ile  Val Ser Ala Thr Asp  Leu Gly Pro 
    1595                 1600                 1605             


Glu Arg  Arg Lys Ser Thr Thr  Glu Leu Thr Ile Ile  Leu Gln Gly 
    1610                 1615                 1620             


Leu Asp  Gly Pro Val Phe Thr  Gln Pro Lys Tyr Ile  Thr Ile Leu 
    1625                 1630                 1635             


Lys Glu  Gly Glu Pro Ile Gly  Thr Asn Val Ile Ser  Ile Glu Ala 
    1640                 1645                 1650             


Ala Ser  Pro Arg Gly Ser Glu  Ala Pro Val Glu Tyr  Tyr Ile Val 
    1655                 1660                 1665             


Ser Val  Arg Cys Glu Glu Lys  Thr Val Gly Arg Leu  Phe Thr Ile 
    1670                 1675                 1680             


Gly Arg  His Thr Gly Ile Ile  Gln Thr Ala Ala Ile  Leu Asp Arg 
    1685                 1690                 1695             


Glu Gln  Gly Ala Cys Leu Tyr  Leu Val Asp Val Tyr  Ala Ile Glu 
    1700                 1705                 1710             


Lys Ser  Thr Ala Phe Pro Arg  Thr Gln Arg Ala Glu  Val Glu Ile 
    1715                 1720                 1725             


Thr Leu  Gln Asp Ile Asn Asp  Asn Pro Pro Val Phe  Pro Thr Asp 
    1730                 1735                 1740             


Met Leu  Asp Leu Thr Val Glu  Glu Asn Ile Gly Asp  Gly Ser Lys 
    1745                 1750                 1755             


Ile Met  Gln Leu Thr Ala Met  Asp Ala Asp Glu Gly  Ala Asn Ala 
    1760                 1765                 1770             


Leu Val  Thr Tyr Thr Ile Ile  Ser Gly Ala Asp Asp  Ser Phe Arg 
    1775                 1780                 1785             


Ile Asp  Pro Glu Ser Gly Asp  Leu Ile Ala Thr Arg  Arg Leu Asp 
    1790                 1795                 1800             


Arg Glu  Arg Arg Ser Lys Tyr  Ser Leu Leu Val Arg  Ala Asp Asp 
    1805                 1810                 1815             


Gly Leu  Gln Ser Ser Asp Met  Arg Ile Asn Ile Thr  Val Ser Asp 
    1820                 1825                 1830             


Val Asn  Asp His Thr Pro Lys  Phe Ser Arg Pro Val  Tyr Ser Phe 
    1835                 1840                 1845             


Asp Ile  Pro Glu Asp Thr Ile  Pro Gly Ser Leu Val  Ala Ala Ile 
    1850                 1855                 1860             


Leu Ala  Thr Asp Asp Asp Ser  Gly Val Asn Gly Glu  Ile Thr Tyr 
    1865                 1870                 1875             


Ile Val  Asn Glu Asp Asp Glu  Asp Gly Ile Phe Phe  Leu Asn Pro 
    1880                 1885                 1890             


Ile Thr  Gly Val Phe Asn Leu  Thr Arg Leu Leu Asp  Tyr Glu Val 
    1895                 1900                 1905             


Gln Gln  Tyr Tyr Ile Leu Thr  Val Arg Ala Glu Asp  Gly Gly Gly 
    1910                 1915                 1920             


Gln Phe  Thr Thr Ile Arg Val  Tyr Phe Asn Ile Leu  Asp Val Asn 
    1925                 1930                 1935             


Asp Asn  Pro Pro Ile Phe Ser  Leu Asn Ser Tyr Ser  Thr Ser Leu 
    1940                 1945                 1950             


Met Glu  Asn Leu Pro Val Gly  Ser Thr Val Leu Val  Phe Asn Val 
    1955                 1960                 1965             


Thr Asp  Ala Asp Asp Gly Ile  Asn Ser Gln Leu Thr  Tyr Ser Ile 
    1970                 1975                 1980             


Ala Ser  Gly Asp Ser Leu Gly  Gln Phe Thr Val Asp  Lys Asn Gly 
    1985                 1990                 1995             


Val Leu  Lys Val Leu Lys Ala  Leu Asp Arg Glu Ser  Gln Ser Phe 
    2000                 2005                 2010             


Tyr Asn  Leu Val Val Gln Val  His Asp Leu Pro Gln  Ile Pro Ala 
    2015                 2020                 2025             


Ser Arg  Phe Thr Ser Thr Ala  Gln Val Ser Ile Ile  Leu Leu Asp 
    2030                 2035                 2040             


Val Asn  Asp Asn Pro Pro Thr  Phe Leu Ser Pro Lys  Leu Thr Tyr 
    2045                 2050                 2055             


Ile Pro  Glu Asn Thr Pro Ile  Asp Thr Val Val Phe  Lys Ala Gln 
    2060                 2065                 2070             


Ala Thr  Asp Pro Asp Ser Gly  Pro Asn Ser Tyr Ile  Glu Tyr Thr 
    2075                 2080                 2085             


Leu Leu  Asn Pro Leu Gly Asn  Lys Phe Ser Ile Gly  Thr Ile Asp 
    2090                 2095                 2100             


Gly Glu  Val Arg Leu Thr Gly  Glu Leu Asp Arg Glu  Glu Val Ser 
    2105                 2110                 2115             


Asn Tyr  Thr Leu Thr Val Val  Ala Thr Asp Lys Gly  Gln Pro Ser 
    2120                 2125                 2130             


Leu Ser  Ser Ser Thr Glu Val  Val Val Met Val Leu  Asp Ile Asn 
    2135                 2140                 2145             


Asp Asn  Asn Pro Ile Phe Ala  Gln Ala Leu Tyr Lys  Val Glu Ile 
    2150                 2155                 2160             


Asn Glu  Asn Thr Leu Thr Gly  Thr Asp Ile Ile Gln  Val Phe Ala 
    2165                 2170                 2175             


Ala Asp  Gly Asp Glu Gly Thr  Asn Gly Gln Val Arg  Tyr Gly Ile 
    2180                 2185                 2190             


Val Asn  Gly Asn Thr Asn Gln  Glu Phe Arg Ile Asp  Ser Val Thr 
    2195                 2200                 2205             


Gly Ala  Ile Thr Val Ala Lys  Pro Leu Asp Arg Glu  Lys Thr Pro 
    2210                 2215                 2220             


Thr Tyr  His Leu Thr Val Gln  Ala Thr Asp Arg Gly  Ser Thr Pro 
    2225                 2230                 2235             


Arg Thr  Asp Thr Ser Thr Val  Ser Ile Val Leu Leu  Asp Ile Asn 
    2240                 2245                 2250             


Asp Phe  Val Pro Val Phe Glu  Leu Ser Pro Tyr Ser  Val Asn Val 
    2255                 2260                 2265             


Pro Glu  Asn Leu Gly Thr Leu  Pro Arg Thr Ile Leu  Gln Val Val 
    2270                 2275                 2280             


Ala Arg  Asp Asp Asp Arg Gly  Ser Asn Ser Lys Leu  Ser Tyr Val 
    2285                 2290                 2295             


Leu Phe  Gly Gly Asn Glu Asp  Asn Ala Phe Thr Leu  Ser Ala Ser 
    2300                 2305                 2310             


Gly Glu  Leu Gly Val Thr Gln  Ser Leu Asp Arg Glu  Thr Lys Glu 
    2315                 2320                 2325             


Arg Phe  Val Leu Met Ile Thr  Ala Thr Asp Ser Gly  Ser Pro Ala 
    2330                 2335                 2340             


Leu Thr  Gly Thr Gly Thr Ile  Asn Val Ile Val Asp  Asp Val Asn 
    2345                 2350                 2355             


Asp Asn  Val Pro Thr Phe Ala  Ser Lys Ala Tyr Phe  Thr Thr Ile 
    2360                 2365                 2370             


Pro Glu  Asp Ala Pro Thr Gly  Thr Asp Val Leu Leu  Val Asn Ala 
    2375                 2380                 2385             


Ser Asp  Ala Asp Ala Ser Lys  Asn Ala Val Ile Arg  Ile Ile Gly 
    2390                 2395                 2400             


Gly Asn  Ser Gln Phe Thr Ile  Asn Pro Ser Thr Gly  Gln Ile Ile 
    2405                 2410                 2415             


Thr Ser  Ala Leu Leu Asp Arg  Glu Thr Lys Asp Asn  Tyr Thr Leu 
    2420                 2425                 2430             


Val Val  Val Cys Ser Asp Ala  Gly Ser Pro Glu Pro  Leu Ser Ser 
    2435                 2440                 2445             


Ser Thr  Ser Val Leu Val Thr  Val Thr Asp Val Asn  Asp Asn Pro 
    2450                 2455                 2460             


Pro Arg  Phe Gln His His Pro  Tyr Val Thr His Ile  Pro Ser Pro 
    2465                 2470                 2475             


Thr Leu  Pro Gly Ser Phe Val  Phe Ala Val Thr Val  Thr Asp Ala 
    2480                 2485                 2490             


Asp Ile  Gly Pro Asn Ser Glu  Leu His Tyr Ser Leu  Ser Gly Arg 
    2495                 2500                 2505             


Asn Ser  Glu Lys Phe His Ile  Asp Pro Leu Arg Gly  Ala Ile Met 
    2510                 2515                 2520             


Ala Ala  Gly Pro Leu Asn Gly  Ala Ser Glu Val Thr  Phe Ser Val 
    2525                 2530                 2535             


His Val  Lys Asp Gly Gly Ser  Phe Pro Lys Thr Asp  Ser Thr Thr 
    2540                 2545                 2550             


Val Thr  Val Arg Phe Val Asn  Lys Ala Asp Phe Pro  Lys Val Arg 
    2555                 2560                 2565             


Ala Lys  Glu Gln Thr Phe Met  Phe Pro Glu Asn Gln  Pro Val Ser 
    2570                 2575                 2580             


Ser Leu  Val Thr Thr Ile Thr  Gly Ser Ser Leu Arg  Gly Glu Pro 
    2585                 2590                 2595             


Met Ser  Tyr Tyr Ile Ala Ser  Gly Asn Leu Gly Asn  Thr Phe Gln 
    2600                 2605                 2610             


Ile Asp  Gln Leu Thr Gly Gln  Val Ser Ile Ser Gln  Pro Leu Asp 
    2615                 2620                 2625             


Phe Glu  Lys Ile Gln Lys Tyr  Val Val Trp Ile Glu  Ala Arg Asp 
    2630                 2635                 2640             


Gly Gly  Phe Pro Pro Phe Ser  Ser Tyr Glu Lys Leu  Asp Ile Thr 
    2645                 2650                 2655             


Val Leu  Asp Val Asn Asp Asn  Ala Pro Ile Phe Lys  Glu Asp Pro 
    2660                 2665                 2670             


Phe Ile  Ser Glu Ile Leu Glu  Asn Leu Ser Pro Arg  Lys Ile Leu 
    2675                 2680                 2685             


Thr Val  Ser Ala Met Asp Lys  Asp Ser Gly Pro Asn  Gly Gln Leu 
    2690                 2695                 2700             


Asp Tyr  Glu Ile Val Asn Gly  Asn Met Glu Asn Ser  Phe Ser Ile 
    2705                 2710                 2715             


Asn His  Ala Thr Gly Glu Ile  Arg Ser Val Arg Pro  Leu Asp Arg 
    2720                 2725                 2730             


Glu Lys  Val Ser His Tyr Val  Leu Thr Ile Lys Ser  Ser Asp Lys 
    2735                 2740                 2745             


Gly Ser  Pro Ser Gln Ser Thr  Ser Val Lys Val Met  Ile Asn Ile 
    2750                 2755                 2760             


Leu Asp  Glu Asn Asp Asn Ala  Pro Arg Phe Ser Gln  Ile Phe Ser 
    2765                 2770                 2775             


Ala His  Val Pro Glu Asn Ser  Pro Leu Gly Tyr Thr  Val Thr Arg 
    2780                 2785                 2790             


Val Thr  Thr Ser Asp Glu Asp  Ile Gly Ile Asn Ala  Ile Ser Arg 
    2795                 2800                 2805             


Tyr Ser  Ile Met Asp Ala Ser  Leu Pro Phe Thr Ile  Asn Pro Ser 
    2810                 2815                 2820             


Thr Gly  Asp Ile Val Ile Ser  Arg Pro Leu Asn Arg  Glu Asp Thr 
    2825                 2830                 2835             


Asp Arg  Tyr Arg Ile Arg Val  Ser Ala His Asp Ser  Gly Trp Thr 
    2840                 2845                 2850             


Val Ser  Thr Asp Val Thr Ile  Phe Val Thr Asp Ile  Asn Asp Asn 
    2855                 2860                 2865             


Ala Pro  Arg Phe Ser Arg Thr  Ser Tyr Tyr Leu Asp  Cys Pro Glu 
    2870                 2875                 2880             


Leu Thr  Glu Ile Gly Ser Lys  Val Thr Gln Val Phe  Ala Thr Asp 
    2885                 2890                 2895             


Pro Asp  Glu Gly Ser Asn Gly  Gln Val Phe Tyr Phe  Ile Lys Ser 
    2900                 2905                 2910             


Gln Ser  Glu Tyr Phe Arg Ile  Asn Ala Thr Thr Gly  Glu Ile Phe 
    2915                 2920                 2925             


Asn Lys  Gln Ile Leu Lys Tyr  Gln Asn Val Thr Gly  Phe Ser Asn 
    2930                 2935                 2940             


Val Asn  Ile Asn Arg His Ser  Phe Ile Val Thr Ser  Ser Asp Arg 
    2945                 2950                 2955             


Gly Lys  Pro Ser Leu Ile Ser  Glu Thr Thr Val Thr  Ile Asn Ile 
    2960                 2965                 2970             


Val Asp  Ser Asn Asp Asn Ala  Pro Gln Phe Leu Lys  Ser Lys Tyr 
    2975                 2980                 2985             


Phe Thr  Pro Val Thr Lys Asn  Val Lys Val Gly Thr  Lys Leu Ile 
    2990                 2995                 3000             


Arg Val  Thr Ala Ile Asp Asp  Lys Asp Phe Gly Leu  Asn Ser Glu 
    3005                 3010                 3015             


Val Glu  Tyr Phe Ile Ser Asn  Asp Asn His Leu Gly  Lys Phe Lys 
    3020                 3025                 3030             


Leu Asp  Asn Asp Thr Gly Trp  Ile Ser Val Ala Ser  Ser Leu Ile 
    3035                 3040                 3045             


Ser Asp  Leu Asn Gln Asn Phe  Phe Ile Thr Val Thr  Ala Lys Asp 
    3050                 3055                 3060             


Lys Gly  Asn Pro Pro Leu Ser  Ser Gln Ala Thr Val  His Ile Thr 
    3065                 3070                 3075             


Val Thr  Glu Glu Asn Tyr His  Thr Pro Glu Phe Ser  Gln Ser His 
    3080                 3085                 3090             


Met Ser  Ala Thr Ile Pro Glu  Ser His Ser Ile Gly  Ser Ile Val 
    3095                 3100                 3105             


Arg Thr  Val Ser Ala Arg Asp  Arg Asp Ala Ala Met  Asn Gly Leu 
    3110                 3115                 3120             


Ile Lys  Tyr Ser Ile Ser Ser  Gly Asn Glu Glu Gly  Ile Phe Ala 
    3125                 3130                 3135             


Ile Asn  Ser Ser Thr Gly Ile  Leu Thr Leu Ala Lys  Ala Leu Asp 
    3140                 3145                 3150             


Tyr Glu  Leu Cys Gln Lys His  Glu Met Thr Ile Ser  Ala Ile Asp 
    3155                 3160                 3165             


Gly Gly  Trp Val Ala Arg Thr  Gly Tyr Cys Ser Val  Thr Val Asn 
    3170                 3175                 3180             


Val Ile  Asp Val Asn Asp Asn  Ser Pro Val Phe Leu  Ser Asp Asp 
    3185                 3190                 3195             


Tyr Phe  Pro Thr Val Leu Glu  Asn Ala Pro Ser Gly  Thr Thr Val 
    3200                 3205                 3210             


Ile His  Leu Asn Ala Thr Asp  Ala Asp Ser Gly Thr  Asn Ala Val 
    3215                 3220                 3225             


Ile Ala  Tyr Thr Val Gln Ser  Ser Asp Ser Asp Leu  Phe Val Ile 
    3230                 3235                 3240             


Asp Pro  Asn Thr Gly Val Ile  Thr Thr Gln Gly Phe  Leu Asp Phe 
    3245                 3250                 3255             


Glu Thr  Lys Gln Ser Tyr His  Leu Thr Val Lys Ala  Phe Asn Val 
    3260                 3265                 3270             


Pro Asp  Glu Glu Arg Cys Ser  Phe Ala Thr Val Asn  Ile Gln Leu 
    3275                 3280                 3285             


Lys Gly  Thr Asn Glu Tyr Val  Pro Arg Phe Val Ser  Lys Leu Tyr 
    3290                 3295                 3300             


Tyr Phe  Glu Ile Ser Glu Ala  Ala Pro Lys Gly Thr  Ile Val Gly 
    3305                 3310                 3315             


Glu Val  Phe Ala Ser Asp Arg  Asp Leu Gly Thr Asp  Gly Glu Val 
    3320                 3325                 3330             


His Tyr  Leu Ile Phe Gly Asn  Ser Arg Lys Lys Gly  Phe Gln Ile 
    3335                 3340                 3345             


Asn Lys  Lys Thr Gly Gln Ile  Tyr Val Ser Gly Ile  Leu Asp Arg 
    3350                 3355                 3360             


Glu Lys  Glu Glu Arg Val Ser  Leu Lys Val Leu Ala  Lys Asn Phe 
    3365                 3370                 3375             


Gly Ser  Ile Arg Gly Ala Asp  Ile Asp Glu Val Thr  Val Asn Val 
    3380                 3385                 3390             


Thr Val  Leu Asp Ala Asn Asp  Pro Pro Ile Phe Thr  Leu Asn Ile 
    3395                 3400                 3405             


Tyr Ser  Val Gln Ile Ser Glu  Gly Val Pro Ile Gly  Thr His Val 
    3410                 3415                 3420             


Thr Phe  Val Ser Ala Phe Asp  Ser Asp Ser Ile Pro  Ser Trp Ser 
    3425                 3430                 3435             


Arg Phe  Ser Tyr Phe Ile Gly  Ser Gly Asn Glu Asn  Gly Ala Phe 
    3440                 3445                 3450             


Ser Ile  Asn Pro Gln Thr Gly  Gln Ile Thr Val Thr  Ala Glu Leu 
    3455                 3460                 3465             


Asp Arg  Glu Thr Leu Pro Ile  Tyr Asn Leu Ser Val  Leu Ala Val 
    3470                 3475                 3480             


Asp Ser  Gly Thr Pro Ser Ala  Thr Gly Ser Ala Ser  Leu Leu Val 
    3485                 3490                 3495             


Thr Leu  Glu Asp Ile Asn Asp  Asn Gly Pro Met Leu  Thr Val Ser 
    3500                 3505                 3510             


Glu Gly  Glu Val Met Glu Asn  Lys Arg Pro Gly Thr  Leu Val Met 
    3515                 3520                 3525             


Thr Leu  Gln Ser Thr Asp Pro  Asp Leu Pro Pro Asn  Gln Gly Pro 
    3530                 3535                 3540             


Phe Thr  Tyr Tyr Leu Leu Ser  Thr Gly Pro Ala Thr  Ser Tyr Phe 
    3545                 3550                 3555             


Ser Leu  Ser Thr Ala Gly Val  Leu Ser Thr Thr Arg  Glu Ile Asp 
    3560                 3565                 3570             


Arg Glu  Gln Ile Ala Asp Phe  Tyr Leu Ser Val Val  Thr Lys Asp 
    3575                 3580                 3585             


Ser Gly  Val Pro Gln Met Ser  Ser Thr Gly Thr Val  His Ile Thr 
    3590                 3595                 3600             


Val Ile  Asp Gln Asn Asp Asn  Pro Ser Gln Ser Arg  Thr Val Glu 
    3605                 3610                 3615             


Ile Phe  Val Asn Tyr Tyr Gly  Asn Leu Phe Pro Gly  Gly Ile Leu 
    3620                 3625                 3630             


Gly Ser  Val Lys Pro Gln Asp  Pro Asp Val Leu Asp  Ser Phe His 
    3635                 3640                 3645             


Cys Ser  Leu Thr Ser Gly Val  Thr Ser Leu Phe Ser  Ile Pro Gly 
    3650                 3655                 3660             


Gly Thr  Cys Asp Leu Asn Ser  Gln Pro Arg Ser Thr  Asp Gly Thr 
    3665                 3670                 3675             


Phe Asp  Leu Thr Val Leu Ser  Asn Asp Gly Val His  Ser Thr Val 
    3680                 3685                 3690             


Thr Ser  Asn Ile Arg Val Phe  Phe Ala Gly Phe Ser  Asn Ala Thr 
    3695                 3700                 3705             


Val Asp  Asn Ser Ile Leu Leu  Arg Leu Gly Val Pro  Thr Val Lys 
    3710                 3715                 3720             


Asp Phe  Leu Thr Asn His Tyr  Leu His Phe Leu Arg  Ile Ala Ser 
    3725                 3730                 3735             


Ser Gln  Leu Thr Gly Leu Gly  Thr Ala Val Gln Leu  Tyr Ser Ala 
    3740                 3745                 3750             


Tyr Glu  Glu Asn Asn Arg Thr  Phe Leu Leu Ala Ala  Val Lys Arg 
    3755                 3760                 3765             


Asn His  Asn Gln Tyr Val Asn  Pro Ser Gly Val Ala  Thr Phe Phe 
    3770                 3775                 3780             


Glu Ser  Ile Lys Glu Ile Leu  Leu Arg Gln Ser Gly  Val Lys Val 
    3785                 3790                 3795             


Glu Ser  Val Asp His Asp Ser  Cys Val His Gly Pro  Cys Gln Asn 
    3800                 3805                 3810             


Gly Gly  Ser Cys Leu Arg Arg  Leu Ala Val Ser Ser  Val Leu Lys 
    3815                 3820                 3825             


Ser Arg  Glu Ser Leu Pro Val  Ile Ile Val Ala Asn  Glu Pro Leu 
    3830                 3835                 3840             


Gln Pro  Phe Leu Cys Lys Cys  Leu Pro Gly Tyr Ala  Gly Ser Trp 
    3845                 3850                 3855             


Cys Glu  Ile Asp Ile Asp Glu  Cys Leu Pro Ser Pro  Cys His Ser 
    3860                 3865                 3870             


Gly Gly  Thr Cys His Asn Leu  Val Gly Gly Phe Ser  Cys Ser Cys 
    3875                 3880                 3885             


Pro Asp  Gly Phe Thr Gly Arg  Ala Cys Glu Arg Asp  Ile Asn Glu 
    3890                 3895                 3900             


Cys Leu  Gln Ser Pro Cys Lys  Asn Gly Ala Ile Cys  Gln Asn Phe 
    3905                 3910                 3915             


Pro Gly  Ser Phe Asn Cys Val  Cys Lys Thr Gly Tyr  Thr Gly Lys 
    3920                 3925                 3930             


Met Cys  Glu Ser Ser Val Asn  Tyr Cys Glu Cys Asn  Pro Cys Phe 
    3935                 3940                 3945             


Asn Gly  Gly Ser Cys Gln Ser  Gly Val Asp Ser Tyr  Tyr Cys His 
    3950                 3955                 3960             


Cys Pro  Phe Gly Val Phe Gly  Lys His Cys Glu Leu  Asn Ser Tyr 
    3965                 3970                 3975             


Gly Phe  Glu Glu Leu Ser Tyr  Met Glu Phe Pro Ser  Leu Asp Pro 
    3980                 3985                 3990             


Asn Asn  Asn Tyr Ile Tyr Val  Lys Phe Ala Thr Ile  Lys Ser His 
    3995                 4000                 4005             


Ala Leu  Leu Leu Tyr Asn Tyr  Asp Asn Gln Thr Gly  Asp Arg Ala 
    4010                 4015                 4020             


Glu Phe  Leu Ala Leu Glu Ile  Ala Glu Glu Arg Leu  Arg Phe Ser 
    4025                 4030                 4035             


Tyr Asn  Leu Gly Ser Gly Thr  Tyr Lys Leu Thr Thr  Met Lys Lys 
    4040                 4045                 4050             


Val Ser  Asp Gly His Phe His  Thr Val Ile Ala Arg  Arg Ala Gly 
    4055                 4060                 4065             


Met Ala  Ala Ser Leu Thr Val  Asp Ser Cys Ser Glu  Asn Gln Glu 
    4070                 4075                 4080             


Pro Gly  Tyr Cys Thr Val Ser  Asn Val Ala Val Ser  Asp Asp Trp 
    4085                 4090                 4095             


Thr Leu  Asp Val Gln Pro Asn  Arg Val Thr Val Gly  Gly Ile Arg 
    4100                 4105                 4110             


Ser Leu  Glu Pro Ile Leu Gln  Arg Arg Gly His Val  Glu Ser His 
    4115                 4120                 4125             


Asp Phe  Val Gly Cys Ile Met  Glu Phe Ala Val Asn  Gly Arg Pro 
    4130                 4135                 4140             


Leu Glu  Pro Ser Gln Ala Leu  Ala Ala Gln Gly Ile  Leu Asp Gln 
    4145                 4150                 4155             


Cys Pro  Arg Leu Glu Gly Ala  Cys Thr Arg Ser Pro  Cys Gln His 
    4160                 4165                 4170             


Gly Gly  Thr Cys Met Asp Tyr  Trp Ser Trp Gln Gln  Cys His Cys 
    4175                 4180                 4185             


Lys Glu  Gly Leu Thr Gly Lys  Tyr Cys Glu Lys Ser  Val Thr Pro 
    4190                 4195                 4200             


Asp Thr  Ala Leu Ser Leu Glu  Gly Lys Gly Arg Leu  Asp Tyr His 
    4205                 4210                 4215             


Met Ser  Gln Asn Glu Lys Arg  Glu Tyr Leu Leu Arg  Gln Ser Leu 
    4220                 4225                 4230             


Arg Gly  Ala Met Leu Glu Pro  Phe Gly Val Asn Ser  Leu Glu Val 
    4235                 4240                 4245             


Lys Phe  Arg Thr Arg Ser Glu  Asn Gly Val Leu Ile  His Ile Gln 
    4250                 4255                 4260             


Glu Ser  Ser Asn Tyr Thr Thr  Val Lys Ile Lys Asn  Gly Lys Val 
    4265                 4270                 4275             


Tyr Phe  Thr Ser Asp Ala Gly  Ile Ala Gly Lys Val  Glu Arg Asn 
    4280                 4285                 4290             


Ile Pro  Glu Val Tyr Val Ala  Asp Gly His Trp His  Thr Phe Leu 
    4295                 4300                 4305             


Ile Gly  Lys Asn Gly Thr Ala  Thr Val Leu Ser Val  Asp Arg Ile 
    4310                 4315                 4320             


Tyr Asn  Arg Asp Ile Ile His  Pro Thr Gln Asp Phe  Gly Gly Leu 
    4325                 4330                 4335             


Asp Val  Leu Thr Ile Ser Leu  Gly Gly Ile Pro Pro  Asn Gln Ala 
    4340                 4345                 4350             


His Arg  Asp Ala Gln Thr Ala  Gly Phe Asp Gly Cys  Ile Ala Ser 
    4355                 4360                 4365             


Met Trp  Tyr Gly Gly Glu Ser  Leu Pro Phe Ser Gly  Lys His Ser 
    4370                 4375                 4380             


Leu Ala  Ser Ile Ser Lys Thr  Asp Pro Ser Val Lys  Ile Gly Cys 
    4385                 4390                 4395             


Arg Gly  Pro Asn Ile Cys Ala  Ser Asn Pro Cys Trp  Gly Asp Leu 
    4400                 4405                 4410             


Leu Cys  Ile Asn Gln Trp Tyr  Ala Tyr Arg Cys Val  Pro Pro Gly 
    4415                 4420                 4425             


Asp Cys  Ala Ser His Pro Cys  Gln Asn Gly Gly Ser  Cys Glu Pro 
    4430                 4435                 4440             


Gly Leu  His Ser Gly Phe Thr  Cys Ser Cys Pro Asp  Ser His Thr 
    4445                 4450                 4455             


Gly Arg  Thr Cys Glu Met Val  Val Ala Cys Leu Gly  Val Leu Cys 
    4460                 4465                 4470             


Pro Gln  Gly Lys Val Cys Lys  Ala Gly Ser Pro Ala  Gly His Val 
    4475                 4480                 4485             


Cys Val  Leu Ser Gln Gly Pro  Glu Glu Ile Ser Leu  Pro Leu Trp 
    4490                 4495                 4500             


Ala Val  Pro Ala Ile Val Gly  Ser Cys Ala Thr Val  Leu Ala Leu 
    4505                 4510                 4515             


Leu Val  Leu Ser Leu Ile Leu  Cys Asn Gln Cys Arg  Gly Lys Lys 
    4520                 4525                 4530             


Ala Lys  Asn Pro Lys Glu Glu  Lys Lys Pro Lys Glu  Lys Lys Lys 
    4535                 4540                 4545             


Lys Gly  Ser Glu Asn Val Ala  Phe Asp Asp Pro Asp  Asn Ile Pro 
    4550                 4555                 4560             


Pro Tyr  Gly Asp Asp Met Thr  Val Arg Lys Gln Pro  Glu Gly Asn 
    4565                 4570                 4575             


Pro Lys  Pro Asp Ile Ile Glu  Arg Glu Asn Pro Tyr  Leu Ile Tyr 
    4580                 4585                 4590             


Asp Glu  Thr Asp Ile Pro His  Asn Ser Glu Thr Ile  Pro Ser Ala 
    4595                 4600                 4605             


Pro Leu  Ala Ser Pro Glu Gln  Glu Ile Glu His Tyr  Asp Ile Asp 
    4610                 4615                 4620             


Asn Ala  Ser Ser Ile Ala Pro  Ser Asp Ala Asp Ile  Ile Gln His 
    4625                 4630                 4635             


Tyr Lys  Gln Phe Arg Ser His  Thr Pro Lys Phe Ser  Ile Gln Arg 
    4640                 4645                 4650             


His Ser  Pro Leu Gly Phe Ala  Arg Gln Ser Pro Met  Pro Leu Gly 
    4655                 4660                 4665             


Ala Ser  Ser Leu Thr Tyr Gln  Pro Ser Tyr Gly Gln  Gly Leu Arg 
    4670                 4675                 4680             


Thr Ser  Ser Leu Ser His Ser  Ala Cys Pro Thr Pro  Asn Pro Leu 
    4685                 4690                 4695             


Ser Arg  His Ser Pro Ala Pro  Phe Ser Lys Ser Ser  Thr Phe Tyr 
    4700                 4705                 4710             


Arg Asn  Ser Pro Ala Arg Glu  Leu His Leu Pro Ile  Arg Asp Gly 
    4715                 4720                 4725             


Asn Thr  Leu Glu Met His Gly  Asp Thr Cys Gln Pro  Gly Ile Phe 
    4730                 4735                 4740             


Asn Tyr  Ala Thr Arg Leu Gly  Arg Arg Ser Lys Ser  Pro Gln Ala 
    4745                 4750                 4755             


Met Ala  Ser His Gly Ser Arg  Pro Gly Ser Arg Leu  Lys Gln Pro 
    4760                 4765                 4770             


Ile Gly  Gln Ile Pro Leu Glu  Ser Ser Pro Pro Val  Gly Leu Ser 
    4775                 4780                 4785             


Ile Glu  Glu Val Glu Arg Leu  Asn Thr Pro Arg Pro  Arg Asn Pro 
    4790                 4795                 4800             


Ser Ile  Cys Ser Ala Asp His  Gly Arg Ser Ser Ser  Glu Glu Asp 
    4805                 4810                 4815             


Cys Arg  Arg Pro Leu Ser Arg  Thr Arg Asn Pro Ala  Asp Gly Ile 
    4820                 4825                 4830             


Pro Ala  Pro Glu Ser Ser Ser  Asp Ser Asp Ser His  Glu Ser Phe 
    4835                 4840                 4845             


Thr Cys  Ser Glu Met Glu Tyr  Asp Arg Glu Lys Pro  Met Val Tyr 
    4850                 4855                 4860             


Thr Ser  Arg Met Pro Lys Leu  Ser Gln Val Asn Glu  Ser Asp Ala 
    4865                 4870                 4875             


Asp Asp  Glu Asp Asn Tyr Gly  Ala Arg Leu Lys Pro  Arg Arg Tyr 
    4880                 4885                 4890             


His Gly  Arg Arg Ala Glu Gly  Gly Pro Val Gly Thr  Gln Ala Ala 
    4895                 4900                 4905             


Ala Pro  Gly Thr Ala Asp Asn  Thr Leu Pro Met Lys  Leu Gly Gln 
    4910                 4915                 4920             


Gln Ala  Gly Thr Phe Asn Trp  Asp Asn Leu Leu Asn  Trp Gly Pro 
    4925                 4930                 4935             


Gly Phe  Gly His Tyr Val Asp  Val Phe Lys Asp Leu  Ala Ser Leu 
    4940                 4945                 4950             


Pro Glu  Lys Ala Ala Ala Asn  Glu Glu Gly Lys Ala  Gly Thr Thr 
    4955                 4960                 4965             


Lys Pro  Val Pro Lys Asp Gly  Glu Ala Glu Gln Tyr  Val 
    4970                 4975                 4980     


<210>  3908
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FATE1__Homo_sapiens__NP_149076

<400>  3908

Met Ala Gly Gly Pro Pro Asn Thr Lys Ala Glu Met Glu Met Ser Leu 
1               5                   10                  15      


Ala Glu Glu Leu Asn His Gly Arg Gln Gly Glu Asn Gln Glu His Leu 
            20                  25                  30          


Val Ile Ala Glu Met Met Glu Leu Gly Ser Arg Ser Arg Gly Ala Ser 
        35                  40                  45              


Gln Lys Lys Gln Lys Leu Glu Gln Lys Ala Ala Gly Ser Ala Ser Ala 
    50                  55                  60                  


Lys Arg Val Trp Asn Met Thr Ala Thr Arg Pro Lys Lys Met Gly Ser 
65                  70                  75                  80  


Gln Leu Pro Lys Pro Arg Met Leu Arg Glu Ser Gly His Gly Asp Ala 
                85                  90                  95      


His Leu Gln Glu Tyr Ala Gly Asn Phe Gln Gly Ile Arg Phe His Tyr 
            100                 105                 110         


Asp Arg Asn Pro Gly Thr Asp Ala Val Ala Gln Thr Ser Leu Glu Glu 
        115                 120                 125             


Phe Asn Val Leu Glu Met Glu Val Met Arg Arg Gln Leu Tyr Ala Val 
    130                 135                 140                 


Asn Arg Arg Leu Arg Ala Leu Glu Glu Gln Gly Ala Thr Trp Arg His 
145                 150                 155                 160 


Arg Glu Thr Leu Ile Ile Ala Val Leu Val Ser Ala Ser Ile Ala Asn 
                165                 170                 175     


Leu Trp Leu Trp Met Asn Gln 
            180             


<210>  3909
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAU__Homo_sapiens__NP_001988

<400>  3909

Met Gln Leu Phe Val Arg Ala Gln Glu Leu His Thr Phe Glu Val Thr 
1               5                   10                  15      


Gly Gln Glu Thr Val Ala Gln Ile Lys Ala His Val Ala Ser Leu Glu 
            20                  25                  30          


Gly Ile Ala Pro Glu Asp Gln Val Val Leu Leu Ala Gly Ala Pro Leu 
        35                  40                  45              


Glu Asp Glu Ala Thr Leu Gly Gln Cys Gly Val Glu Ala Leu Thr Thr 
    50                  55                  60                  


Leu Glu Val Ala Gly Arg Met Leu Gly Gly Lys Val His Gly Ser Leu 
65                  70                  75                  80  


Ala Arg Ala Gly Lys Val Arg Gly Gln Thr Pro Lys Val Ala Lys Gln 
                85                  90                  95      


Glu Lys Lys Lys Lys Lys Thr Gly Arg Ala Lys Arg Arg Met Gln Tyr 
            100                 105                 110         


Asn Arg Arg Phe Val Asn Val Val Pro Thr Phe Gly Lys Lys Lys Gly 
        115                 120                 125             


Pro Asn Ala Asn Ser 
    130             


<210>  3910
<211>  1133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBF1__Homo_sapiens__NP_001074011

<400>  3910

Met Ala Pro Lys Thr Lys Lys Gly Cys Lys Val Thr Leu Pro Glu Lys 
1               5                   10                  15      


Pro Val Lys Leu Ala Ser His Thr Arg Asp Thr Thr Gly Val Ser Gln 
            20                  25                  30          


Met Phe Pro Ser Ser Lys Ala Arg Thr Lys Ser Leu Leu Gly Asp Asp 
        35                  40                  45              


Val Phe Ser Thr Met Ala Gly Leu Glu Glu Ala Asp Ala Glu Val Ser 
    50                  55                  60                  


Gly Ile Ser Glu Ala Asp Pro Gln Ala Leu Leu Gln Ala Met Lys Asp 
65                  70                  75                  80  


Leu Asp Gly Met Asp Ala Asp Ile Leu Gly Leu Lys Lys Ser Asn Ser 
                85                  90                  95      


Ala Pro Ser Lys Lys Ala Ala Lys Asp Pro Gly Lys Gly Glu Leu Pro 
            100                 105                 110         


Asn His Pro Lys Pro Ala Gly Gly Ala Ile Pro Thr Lys Lys Ser Leu 
        115                 120                 125             


Pro Ser Pro Ser Ser Ser Gly His Gln Asn Arg Arg Phe Ser Ser Glu 
    130                 135                 140                 


Asp Leu Glu Asp Pro Leu Arg Gly Leu Leu Ser Tyr Asp Glu Gly Gly 
145                 150                 155                 160 


Ile Thr Lys Gln Pro Pro Val Thr Gln Ser Lys Thr Ala Ser Asp Lys 
                165                 170                 175     


Ser Pro Ser Thr Val Arg Asp Gln Gly Pro Ser Ile Pro Leu Thr Pro 
            180                 185                 190         


Gly Asp Thr Pro Ile Arg Lys Lys Glu Glu Leu Leu Phe Asp Asp Gly 
        195                 200                 205             


Asp Asp Ile Met Ala Thr Leu Gly Phe Gly Asp Ser Pro Lys Ala Glu 
    210                 215                 220                 


Lys Arg Gln Ile Gly Asp Gln Glu Gly Pro Arg Pro Ala Arg Ser Thr 
225                 230                 235                 240 


Leu Asp Glu Leu Leu Gly Arg Gly Met Ala Thr Lys Leu Leu Ala Arg 
                245                 250                 255     


Pro Gly Thr Gly Glu His Arg Glu Phe Lys Leu Asp Lys Lys Tyr Gln 
            260                 265                 270         


Arg Pro Gln Asp Ser Glu Asp Met Trp Gly Asp Glu Asp Phe Thr Phe 
        275                 280                 285             


Gly Ala Tyr Gln Pro Thr Val Val Ser Ser Glu Gly Arg Gln Ser Arg 
    290                 295                 300                 


Arg Gln Ser Val Arg Phe Phe Ala Asp Ser Gly Ala Asp Pro Lys Gly 
305                 310                 315                 320 


Glu Pro Gly Ser Lys Gln Ser Pro Pro Met Ala Ser Ser Pro Ile Gln 
                325                 330                 335     


Pro Arg Lys Gly Gly Ala Asp Trp Leu Gly Leu Lys Asp Glu Asp Leu 
            340                 345                 350         


Asp Leu Phe Pro Ala Ser Pro Thr Arg Glu Ala His Arg Glu Ser Ser 
        355                 360                 365             


Val Pro Val Thr Pro Ser Val Pro Pro Pro Ala Ser Gln His Ser Thr 
    370                 375                 380                 


Pro Ala Gly Leu Pro Pro Ser Arg Ala Lys Pro Pro Thr Glu Gly Ala 
385                 390                 395                 400 


Gly Ser Pro Ala Lys Ala Ser Gln Ala Ser Lys Leu Arg Ala Ser Lys 
                405                 410                 415     


Glu Glu Lys Glu Asp Trp Leu Ser His Ala Leu Ser Arg Lys Lys Ser 
            420                 425                 430         


Gln Gly Leu Ala Arg Glu Gln His Ala Gly Thr Ser Glu Gly Leu His 
        435                 440                 445             


Leu Ala Gly Thr Ala Gly His Pro Pro Ser Gly Ser Gln Pro Leu Thr 
    450                 455                 460                 


Ser Thr Gln Gly Leu Glu His Ala Ala Ala Gly Gly Ser Ser Gly Thr 
465                 470                 475                 480 


Thr Ala Arg Glu Arg Pro Cys Val Arg Pro Gly Val Ser Gly Ser Pro 
                485                 490                 495     


Val Thr Gln Asn His Ala Ala Ser Ala Leu Pro Thr Gly Ser Pro Lys 
            500                 505                 510         


Arg Gly Thr Ala Pro Gly Asp Leu Ser Ala Thr Glu Pro Ala Thr Cys 
        515                 520                 525             


Phe Pro Ser Thr Gln Lys Pro Thr Glu Pro Ser Val Pro Val Gln Pro 
    530                 535                 540                 


Leu Leu Pro Glu Ser Leu Ala Arg Ser Leu Leu Pro Ser Thr Glu Tyr 
545                 550                 555                 560 


Gln Lys Gln Leu Leu Ala Ala Gln Val Gln Leu Gln Cys Ser Pro Ala 
                565                 570                 575     


Glu Leu Gln Ala Glu Leu Leu His Ser Gln Ala Arg Leu Ala Glu Leu 
            580                 585                 590         


Glu Ala Gln Val Arg Lys Leu Glu Leu Glu Arg Ala Gln His Glu Leu 
        595                 600                 605             


Leu Leu Gly Ser Leu Gln Gln Gln His Gln Ala Asp Leu Glu Leu Ile 
    610                 615                 620                 


Glu Ser Ala His Arg Ser Arg Ile Lys Val Leu Glu Thr Ser Tyr Gln 
625                 630                 635                 640 


Gln Arg Glu Glu Arg Leu Arg Arg Glu Asn Glu Glu Leu Ser Ala Arg 
                645                 650                 655     


Tyr Leu Ser Gln Cys Gln Glu Ala Glu Gln Ala Arg Ala Glu Leu Thr 
            660                 665                 670         


Ala Gln His Gln Arg Arg Leu Ala Ala Ile Ala Gln Glu Lys Asp Gln 
        675                 680                 685             


Glu Met Glu Arg Leu Arg Glu Leu Gln Arg Ala Ser Ile Leu Asp Met 
    690                 695                 700                 


Arg Arg Asp His Glu Glu Gln Leu Gln Arg Leu Lys Leu Leu Lys Asp 
705                 710                 715                 720 


Arg Glu Val Asp Ala Ala Thr Ser Ala Thr Ser His Thr Arg Ser Leu 
                725                 730                 735     


Asn Ser Ile Ile His Gln Met Glu Lys Phe Ser Ser Ser Leu His Glu 
            740                 745                 750         


Leu Ser Ser Arg Val Glu Ala Ser His Leu Thr Thr Ser Gln Glu Arg 
        755                 760                 765             


Glu Leu Gly Ile Arg Gln Arg Asp Glu Gln Leu Arg Ala Leu Gln Glu 
    770                 775                 780                 


Arg Leu Gly Gln Gln Gln Arg Asp Met Glu Glu Glu Arg Ser Arg Gln 
785                 790                 795                 800 


Gln Glu Val Ile Gly Lys Met Glu Ala Arg Leu Asn Glu Gln Ser Arg 
                805                 810                 815     


Leu Leu Glu Gln Glu Arg Trp Arg Val Thr Ala Glu Gln Ser Lys Ala 
            820                 825                 830         


Glu Ser Met Gln Arg Ala Leu Glu Glu Gln Arg Lys Val Thr Ala Gln 
        835                 840                 845             


Gln Met Ala Met Glu Arg Ala Glu Leu Glu Arg Ala Lys Ser Ala Leu 
    850                 855                 860                 


Leu Glu Glu Gln Lys Ser Val Met Leu Lys Cys Gly Glu Glu Arg Arg 
865                 870                 875                 880 


Arg Leu Ala Ala Glu Trp Ala Glu Phe Ser Ala Gln Gln Lys Leu Ser 
                885                 890                 895     


Lys Glu Arg Ala Glu Arg Glu Ala Glu Arg Ala Leu Gln Val Asp Thr 
            900                 905                 910         


Gln Arg Glu Gly Thr Leu Ile Ser Leu Ala Lys Glu Gln Ala Glu Leu 
        915                 920                 925             


Lys Ile Arg Ala Ser Glu Leu Arg Ala Glu Glu Lys Gln Leu Ala Ala 
    930                 935                 940                 


Glu Arg Ala Ala Leu Glu Gln Glu Arg Gln Glu Leu Arg Leu Glu Lys 
945                 950                 955                 960 


Glu Arg Ile Asn Ala Thr Ala Leu Arg Val Lys Leu Arg Ala Glu Glu 
                965                 970                 975     


Val Glu Ser Met Ser Lys Val Ala Ser Glu Lys Tyr Glu Glu Gly Glu 
            980                 985                 990         


Arg Ala Leu Arg Glu Ala Gln Gln  Val Gln Ala Glu Gln  Gln Ala Arg 
        995                 1000                 1005             


Leu Gln  Ala Val Gln Gln Gln  Gln Glu Arg Leu Arg  Lys Gln Glu 
    1010                 1015                 1020             


Gln His  Met His Gln Glu His  Leu Ser Leu Ala Gln  Gln Arg Leu 
    1025                 1030                 1035             


Gln Leu  Asp Arg Ala Arg Gln  Asp Leu Pro Ser Ser  Leu Val Gly 
    1040                 1045                 1050             


Leu Phe  Pro Arg Ala Gln Gly  Pro Ala Ala Ser Ser  Gln Ser Ala 
    1055                 1060                 1065             


Leu Met  Pro Pro Ala Pro Thr  Thr Arg Trp Cys Ser  Gln Pro Pro 
    1070                 1075                 1080             


Thr Gly  Leu Asp Pro Ser Pro  Leu His Leu His Ala  Arg Leu Ala 
    1085                 1090                 1095             


Leu Leu  Arg His Met Ala Glu  Gln Asp Arg Asp Phe  Leu Glu Asn 
    1100                 1105                 1110             


Glu Gln  Phe Phe Leu Glu Thr  Leu Lys Lys Gly Ser  Tyr Asn Leu 
    1115                 1120                 1125             


Thr Ser  His Ser Ala 
    1130             


<210>  3911
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBL__Homo_sapiens__NP_001427

<400>  3911

Met Lys Pro Gly Phe Ser Pro Arg Gly Gly Gly Phe Gly Gly Arg Gly 
1               5                   10                  15      


Gly Phe Gly Asp Arg Gly Gly Arg Gly Gly Arg Gly Gly Phe Gly Gly 
            20                  25                  30          


Gly Arg Gly Arg Gly Gly Gly Phe Arg Gly Arg Gly Arg Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Gly Gly Gly Gly Phe 
    50                  55                  60                  


His Ser Gly Gly Asn Arg Gly Arg Gly Arg Gly Gly Lys Arg Gly Asn 
65                  70                  75                  80  


Gln Ser Gly Lys Asn Val Met Val Glu Pro His Arg His Glu Gly Val 
                85                  90                  95      


Phe Ile Cys Arg Gly Lys Glu Asp Ala Leu Val Thr Lys Asn Leu Val 
            100                 105                 110         


Pro Gly Glu Ser Val Tyr Gly Glu Lys Arg Val Ser Ile Ser Glu Gly 
        115                 120                 125             


Asp Asp Lys Ile Glu Tyr Arg Ala Trp Asn Pro Phe Arg Ser Lys Leu 
    130                 135                 140                 


Ala Ala Ala Ile Leu Gly Gly Val Asp Gln Ile His Ile Lys Pro Gly 
145                 150                 155                 160 


Ala Lys Val Leu Tyr Leu Gly Ala Ala Ser Gly Thr Thr Val Ser His 
                165                 170                 175     


Val Ser Asp Ile Val Gly Pro Asp Gly Leu Val Tyr Ala Val Glu Phe 
            180                 185                 190         


Ser His Arg Ser Gly Arg Asp Leu Ile Asn Leu Ala Lys Lys Arg Thr 
        195                 200                 205             


Asn Ile Ile Pro Val Ile Glu Asp Ala Arg His Pro His Lys Tyr Arg 
    210                 215                 220                 


Met Leu Ile Ala Met Val Asp Val Ile Phe Ala Asp Val Ala Gln Pro 
225                 230                 235                 240 


Asp Gln Thr Arg Ile Val Ala Leu Asn Ala His Thr Phe Leu Arg Asn 
                245                 250                 255     


Gly Gly His Phe Val Ile Ser Ile Lys Ala Asn Cys Ile Asp Ser Thr 
            260                 265                 270         


Ala Ser Ala Glu Ala Val Phe Ala Ser Glu Val Lys Lys Met Gln Gln 
        275                 280                 285             


Glu Asn Met Lys Pro Gln Glu Gln Leu Thr Leu Glu Pro Tyr Glu Arg 
    290                 295                 300                 


Asp His Ala Val Val Val Gly Val Tyr Arg Pro Pro Pro Lys Val Lys 
305                 310                 315                 320 


Asn 
    


<210>  3912
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBLIM1__Homo_sapiens__XP_011539920

<400>  3912

Met Ala Ser Lys Pro Glu Lys Arg Val Ala Ser Ser Val Phe Ile Thr 
1               5                   10                  15      


Leu Ala Pro Pro Arg Arg Asp Val Ala Val Ala Glu Glu Val Arg Gln 
            20                  25                  30          


Ala Val Cys Glu Ala Arg Arg Gly Arg Pro Trp Glu Ala Pro Ala Pro 
        35                  40                  45              


Met Lys Thr Pro Glu Ala Gly Leu Ala Gly Arg Pro Ser Pro Trp Thr 
    50                  55                  60                  


Thr Pro Gly Arg Ala Ala Ala Thr Val Pro Ala Ala Pro Met Gln Leu 
65                  70                  75                  80  


Phe Asn Gly Gly Cys Pro Pro Pro Pro Pro Val Leu Asp Gly Glu Asp 
                85                  90                  95      


Val Leu Pro Asp Leu Asp Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Val Leu Leu Pro Ser Glu Glu Glu Ala Pro Ala Pro Met Gly Ala Ser 
        115                 120                 125             


Leu Ile Ala Asp Leu Glu Gln Leu His Leu Ser Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Ala Pro Ala Glu Gly Pro Ser Val Gln Pro Gly Pro Leu Arg 
145                 150                 155                 160 


Pro Met Glu Glu Glu Leu Pro Pro Pro Pro Ala Glu Pro Val Glu Lys 
                165                 170                 175     


Gly Ala Ser Thr Asp Ile Cys Ala Phe Cys His Lys Thr Val Ser Pro 
            180                 185                 190         


Arg Glu Leu Ala Val Glu Ala Met Lys Arg Gln Tyr His Ala Gln Cys 
        195                 200                 205             


Phe Thr Cys Arg Thr Cys Arg Arg Gln Leu Ala Gly Gln Ser Phe Tyr 
    210                 215                 220                 


Gln Lys Asp Gly Arg Pro Leu Cys Glu Pro Cys Tyr Gln Asp Thr Leu 
225                 230                 235                 240 


Glu Arg Cys Gly Lys Cys Gly Glu Val Val Arg Asp His Ile Ile Arg 
                245                 250                 255     


Ala Leu Gly Gln Ala Phe His Pro Ser Cys Phe Thr Cys Val Thr Cys 
            260                 265                 270         


Ala Arg Cys Ile Gly Asp Glu Ser Phe Ala Leu Gly Ser Gln Asn Glu 
        275                 280                 285             


Val Tyr Cys Leu Asp Asp Phe Tyr Arg Thr Ala Gly Ser Ser Cys Leu 
    290                 295                 300                 


Ser Ser Pro Arg Thr Lys Ala Ala Thr Pro 
305                 310                 


<210>  3913
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBLN1__Homo_sapiens__NP_001987

<400>  3913

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Arg Cys Glu Arg Leu Pro Cys His Glu Asn 
                565                 570                 575     


Arg Glu Cys Ser Lys Leu Pro Leu Arg Ile Thr Tyr Tyr His Leu Ser 
            580                 585                 590         


Phe Pro Thr Asn Ile Gln Ala Pro Ala Val Val Phe Arg Met Gly Pro 
        595                 600                 605             


Ser Ser Ala Val Pro Gly Asp Ser Met Gln Leu Ala Ile Thr Gly Gly 
    610                 615                 620                 


Asn Glu Glu Gly Phe Phe Thr Thr Arg Lys Val Ser Pro His Ser Gly 
625                 630                 635                 640 


Val Val Ala Leu Thr Lys Pro Val Pro Glu Pro Arg Asp Leu Leu Leu 
                645                 650                 655     


Thr Val Lys Met Asp Leu Ser Arg His Gly Thr Val Ser Ser Phe Val 
            660                 665                 670         


Ala Lys Leu Phe Ile Phe Val Ser Ala Glu Leu 
        675                 680             


<210>  3914
<211>  1231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBLN2__Homo_sapiens__NP_001158507

<400>  3914

Met Val Leu Leu Trp Glu Pro Ala Gly Ala Trp Leu Ala Leu Gly Leu 
1               5                   10                  15      


Ala Leu Ala Leu Gly Pro Ser Val Ala Ala Ala Ala Pro Arg Gln Asp 
            20                  25                  30          


Cys Thr Gly Val Glu Cys Pro Pro Leu Glu Asn Cys Ile Glu Glu Ala 
        35                  40                  45              


Leu Glu Pro Gly Ala Cys Cys Ala Thr Cys Val Gln Gln Gly Cys Ala 
    50                  55                  60                  


Cys Glu Gly Tyr Gln Tyr Tyr Asp Cys Leu Gln Gly Gly Phe Val Arg 
65                  70                  75                  80  


Gly Arg Val Pro Ala Gly Gln Ser Tyr Phe Val Asp Phe Gly Ser Thr 
                85                  90                  95      


Glu Cys Ser Cys Pro Pro Gly Gly Gly Lys Ile Ser Cys Gln Phe Met 
            100                 105                 110         


Leu Cys Pro Glu Leu Pro Pro Asn Cys Ile Glu Ala Val Val Val Ala 
        115                 120                 125             


Asp Ser Cys Pro Gln Cys Gly Gln Val Gly Cys Val His Ala Gly His 
    130                 135                 140                 


Lys Tyr Ala Ala Gly His Thr Val His Leu Pro Pro Cys Arg Ala Cys 
145                 150                 155                 160 


His Cys Pro Asp Ala Gly Gly Glu Leu Ile Cys Tyr Gln Leu Pro Gly 
                165                 170                 175     


Cys His Gly Asn Phe Ser Asp Ala Glu Glu Gly Asp Pro Glu Arg His 
            180                 185                 190         


Tyr Glu Asp Pro Tyr Ser Tyr Asp Gln Glu Val Ala Glu Val Glu Ala 
        195                 200                 205             


Ala Thr Ala Leu Gly Gly Glu Val Gln Ala Gly Ala Val Gln Ala Gly 
    210                 215                 220                 


Ala Gly Gly Pro Pro Ala Ala Leu Gly Gly Gly Ser Gln Pro Leu Ser 
225                 230                 235                 240 


Thr Ile Gln Ala Pro Pro Trp Pro Ala Val Leu Pro Arg Pro Thr Ala 
                245                 250                 255     


Ala Ala Ala Leu Gly Pro Pro Ala Pro Val Gln Ala Lys Ala Arg Arg 
            260                 265                 270         


Val Thr Glu Asp Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Arg Glu 
        275                 280                 285             


Glu Met Ala Val Thr Glu Gln Leu Ala Ala Gly Gly His Arg Gly Leu 
    290                 295                 300                 


Asp Gly Leu Pro Thr Thr Ala Pro Ala Gly Pro Ser Leu Pro Ile Gln 
305                 310                 315                 320 


Glu Glu Arg Ala Glu Ala Gly Ala Arg Ala Glu Ala Gly Ala Arg Pro 
                325                 330                 335     


Glu Glu Asn Leu Ile Leu Asp Ala Gln Ala Thr Ser Arg Ser Thr Gly 
            340                 345                 350         


Pro Glu Gly Val Thr His Ala Pro Ser Leu Gly Lys Ala Ala Leu Val 
        355                 360                 365             


Pro Thr Gln Ala Val Pro Gly Ser Pro Arg Asp Pro Val Lys Pro Ser 
    370                 375                 380                 


Pro His Asn Ile Leu Ser Thr Ser Leu Pro Asp Ala Ala Trp Ile Pro 
385                 390                 395                 400 


Pro Thr Arg Glu Val Pro Arg Lys Pro Gln Val Leu Pro His Ser His 
                405                 410                 415     


Val Glu Glu Asp Thr Asp Pro Asn Ser Val His Ser Ile Pro Arg Ser 
            420                 425                 430         


Ser Pro Glu Gly Ser Thr Lys Asp Leu Ile Glu Thr Cys Cys Ala Ala 
        435                 440                 445             


Gly Gln Gln Trp Ala Ile Asp Asn Asp Glu Cys Leu Glu Ile Pro Glu 
    450                 455                 460                 


Ser Gly Thr Glu Asp Asn Val Cys Arg Thr Ala Gln Arg His Cys Cys 
465                 470                 475                 480 


Val Ser Tyr Leu Gln Glu Lys Ser Cys Met Ala Gly Val Leu Gly Ala 
                485                 490                 495     


Lys Glu Gly Glu Thr Cys Gly Ala Glu Asp Asn Asp Ser Cys Gly Ile 
            500                 505                 510         


Ser Leu Tyr Lys Gln Cys Cys Asp Cys Cys Gly Leu Gly Leu Arg Val 
        515                 520                 525             


Arg Ala Glu Gly Gln Ser Cys Glu Ser Asn Pro Asn Leu Gly Tyr Pro 
    530                 535                 540                 


Cys Asn His Val Met Leu Ser Cys Cys Glu Gly Glu Glu Pro Leu Ile 
545                 550                 555                 560 


Val Pro Glu Val Arg Arg Pro Pro Glu Pro Ala Ala Ala Pro Arg Arg 
                565                 570                 575     


Val Ser Glu Ala Glu Met Ala Gly Arg Glu Ala Leu Ser Leu Gly Thr 
            580                 585                 590         


Glu Ala Glu Leu Pro Asn Ser Leu Pro Gly Asp Asp Gln Asp Glu Cys 
        595                 600                 605             


Leu Leu Leu Pro Gly Glu Leu Cys Gln His Leu Cys Ile Asn Thr Val 
    610                 615                 620                 


Gly Ser Tyr His Cys Ala Cys Phe Pro Gly Phe Ser Leu Gln Asp Asp 
625                 630                 635                 640 


Gly Arg Thr Cys Arg Pro Glu Gly His Pro Pro Gln Pro Glu Ala Pro 
                645                 650                 655     


Gln Glu Pro Ala Leu Lys Ser Glu Phe Ser Gln Val Ala Ser Asn Thr 
            660                 665                 670         


Ile Pro Leu Pro Leu Pro Gln Pro Asn Thr Cys Lys Asp Asn Gly Pro 
        675                 680                 685             


Cys Lys Gln Val Cys Ser Thr Val Gly Gly Ser Ala Ile Cys Ser Cys 
    690                 695                 700                 


Phe Pro Gly Tyr Ala Ile Met Ala Asp Gly Val Ser Cys Glu Asp Gln 
705                 710                 715                 720 


Asp Glu Cys Leu Met Gly Ala His Asp Cys Ser Arg Arg Gln Phe Cys 
                725                 730                 735     


Val Asn Thr Leu Gly Ser Phe Tyr Cys Val Asn His Thr Val Leu Cys 
            740                 745                 750         


Ala Asp Gly Tyr Ile Leu Asn Ala His Arg Lys Cys Val Asp Ile Asn 
        755                 760                 765             


Glu Cys Val Thr Asp Leu His Thr Cys Ser Arg Gly Glu His Cys Val 
    770                 775                 780                 


Asn Thr Leu Gly Ser Phe His Cys Tyr Lys Ala Leu Thr Cys Glu Pro 
785                 790                 795                 800 


Gly Tyr Ala Leu Lys Asp Gly Glu Cys Glu Asp Val Asp Glu Cys Ala 
                805                 810                 815     


Met Gly Thr His Thr Cys Gln Pro Gly Phe Leu Cys Gln Asn Thr Lys 
            820                 825                 830         


Gly Ser Phe Tyr Cys Gln Ala Arg Gln Arg Cys Met Asp Gly Phe Leu 
        835                 840                 845             


Gln Asp Pro Glu Gly Asn Cys Val Asp Ile Asn Glu Cys Thr Ser Leu 
    850                 855                 860                 


Ser Glu Pro Cys Arg Pro Gly Phe Ser Cys Ile Asn Thr Val Gly Ser 
865                 870                 875                 880 


Tyr Thr Cys Gln Arg Asn Pro Leu Ile Cys Ala Arg Gly Tyr His Ala 
                885                 890                 895     


Ser Asp Asp Gly Thr Lys Cys Val Asp Val Asn Glu Cys Glu Thr Gly 
            900                 905                 910         


Val His Arg Cys Gly Glu Gly Gln Val Cys His Asn Leu Pro Gly Ser 
        915                 920                 925             


Tyr Arg Cys Asp Cys Lys Ala Gly Phe Gln Arg Asp Ala Phe Gly Arg 
    930                 935                 940                 


Gly Cys Ile Asp Val Asn Glu Cys Trp Ala Ser Pro Gly Arg Leu Cys 
945                 950                 955                 960 


Gln His Thr Cys Glu Asn Thr Leu Gly Ser Tyr Arg Cys Ser Cys Ala 
                965                 970                 975     


Ser Gly Phe Leu Leu Ala Ala Asp Gly Lys Arg Cys Glu Asp Val Asn 
            980                 985                 990         


Glu Cys Glu Ala Gln Arg Cys Ser  Gln Glu Cys Ala Asn  Ile Tyr Gly 
        995                 1000                 1005             


Ser Tyr  Gln Cys Tyr Cys Arg  Gln Gly Tyr Gln Leu  Ala Glu Asp 
    1010                 1015                 1020             


Gly His  Thr Cys Thr Asp Ile  Asp Glu Cys Ala Gln  Gly Ala Gly 
    1025                 1030                 1035             


Ile Leu  Cys Thr Phe Arg Cys  Leu Asn Val Pro Gly  Ser Tyr Gln 
    1040                 1045                 1050             


Cys Ala  Cys Pro Glu Gln Gly  Tyr Thr Met Thr Ala  Asn Gly Arg 
    1055                 1060                 1065             


Ser Cys  Lys Asp Val Asp Glu  Cys Ala Leu Gly Thr  His Asn Cys 
    1070                 1075                 1080             


Ser Glu  Ala Glu Thr Cys His  Asn Ile Gln Gly Ser  Phe Arg Cys 
    1085                 1090                 1095             


Leu Arg  Phe Glu Cys Pro Pro  Asn Tyr Val Gln Val  Ser Lys Thr 
    1100                 1105                 1110             


Lys Cys  Glu Arg Thr Thr Cys  His Asp Phe Leu Glu  Cys Gln Asn 
    1115                 1120                 1125             


Ser Pro  Ala Arg Ile Thr His  Tyr Gln Leu Asn Phe  Gln Thr Gly 
    1130                 1135                 1140             


Leu Leu  Val Pro Ala His Ile  Phe Arg Ile Gly Pro  Ala Pro Ala 
    1145                 1150                 1155             


Phe Thr  Gly Asp Thr Ile Ala  Leu Asn Ile Ile Lys  Gly Asn Glu 
    1160                 1165                 1170             


Glu Gly  Tyr Phe Gly Thr Arg  Arg Leu Asn Ala Tyr  Thr Gly Val 
    1175                 1180                 1185             


Val Tyr  Leu Gln Arg Ala Val  Leu Glu Pro Arg Asp  Phe Ala Leu 
    1190                 1195                 1200             


Asp Val  Glu Met Lys Leu Trp  Arg Gln Gly Ser Val  Thr Thr Phe 
    1205                 1210                 1215             


Leu Ala  Lys Met His Ile Phe  Phe Thr Thr Phe Ala  Leu 
    1220                 1225                 1230     


<210>  3915
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBLN5__Homo_sapiens__NP_006320

<400>  3915

Met Pro Gly Ile Lys Arg Ile Leu Thr Val Thr Ile Leu Ala Leu Cys 
1               5                   10                  15      


Leu Pro Ser Pro Gly Asn Ala Gln Ala Gln Cys Thr Asn Gly Phe Asp 
            20                  25                  30          


Leu Asp Arg Gln Ser Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Thr 
        35                  40                  45              


Ile Pro Glu Ala Cys Arg Gly Asp Met Met Cys Val Asn Gln Asn Gly 
    50                  55                  60                  


Gly Tyr Leu Cys Ile Pro Arg Thr Asn Pro Val Tyr Arg Gly Pro Tyr 
65                  70                  75                  80  


Ser Asn Pro Tyr Ser Thr Pro Tyr Ser Gly Pro Tyr Pro Ala Ala Ala 
                85                  90                  95      


Pro Pro Leu Ser Ala Pro Asn Tyr Pro Thr Ile Ser Arg Pro Leu Ile 
            100                 105                 110         


Cys Arg Phe Gly Tyr Gln Met Asp Glu Ser Asn Gln Cys Val Asp Val 
        115                 120                 125             


Asp Glu Cys Ala Thr Asp Ser His Gln Cys Asn Pro Thr Gln Ile Cys 
    130                 135                 140                 


Ile Asn Thr Glu Gly Gly Tyr Thr Cys Ser Cys Thr Asp Gly Tyr Trp 
145                 150                 155                 160 


Leu Leu Glu Gly Gln Cys Leu Asp Ile Asp Glu Cys Arg Tyr Gly Tyr 
                165                 170                 175     


Cys Gln Gln Leu Cys Ala Asn Val Pro Gly Ser Tyr Ser Cys Thr Cys 
            180                 185                 190         


Asn Pro Gly Phe Thr Leu Asn Glu Asp Gly Arg Ser Cys Gln Asp Val 
        195                 200                 205             


Asn Glu Cys Ala Thr Glu Asn Pro Cys Val Gln Thr Cys Val Asn Thr 
    210                 215                 220                 


Tyr Gly Ser Phe Ile Cys Arg Cys Asp Pro Gly Tyr Glu Leu Glu Glu 
225                 230                 235                 240 


Asp Gly Val His Cys Ser Asp Met Asp Glu Cys Ser Phe Ser Glu Phe 
                245                 250                 255     


Leu Cys Gln His Glu Cys Val Asn Gln Pro Gly Thr Tyr Phe Cys Ser 
            260                 265                 270         


Cys Pro Pro Gly Tyr Ile Leu Leu Asp Asp Asn Arg Ser Cys Gln Asp 
        275                 280                 285             


Ile Asn Glu Cys Glu His Arg Asn His Thr Cys Asn Leu Gln Gln Thr 
    290                 295                 300                 


Cys Tyr Asn Leu Gln Gly Gly Phe Lys Cys Ile Asp Pro Ile Arg Cys 
305                 310                 315                 320 


Glu Glu Pro Tyr Leu Arg Ile Ser Asp Asn Arg Cys Met Cys Pro Ala 
                325                 330                 335     


Glu Asn Pro Gly Cys Arg Asp Gln Pro Phe Thr Ile Leu Tyr Arg Asp 
            340                 345                 350         


Met Asp Val Val Ser Gly Arg Ser Val Pro Ala Asp Ile Phe Gln Met 
        355                 360                 365             


Gln Ala Thr Thr Arg Tyr Pro Gly Ala Tyr Tyr Ile Phe Gln Ile Lys 
    370                 375                 380                 


Ser Gly Asn Glu Gly Arg Glu Phe Tyr Met Arg Gln Thr Gly Pro Ile 
385                 390                 395                 400 


Ser Ala Thr Leu Val Met Thr Arg Pro Ile Lys Gly Pro Arg Glu Ile 
                405                 410                 415     


Gln Leu Asp Leu Glu Met Ile Thr Val Asn Thr Val Ile Asn Phe Arg 
            420                 425                 430         


Gly Ser Ser Val Ile Arg Leu Arg Ile Tyr Val Ser Gln Tyr Pro Phe 
        435                 440                 445             


<210>  3916
<211>  2871
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBN1__Homo_sapiens__NP_000129

<400>  3916

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Tyr Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  3917
<211>  2912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBN2__Homo_sapiens__NP_001990

<400>  3917

Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu 
1               5                   10                  15      


Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro 
            20                  25                  30          


Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg 
        35                  40                  45              


Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg 
    50                  55                  60                  


Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln 
65                  70                  75                  80  


Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr 
                85                  90                  95      


Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val 
            100                 105                 110         


Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn 
        115                 120                 125             


Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys 
    130                 135                 140                 


Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala 
145                 150                 155                 160 


Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly 
                165                 170                 175     


Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Gly 
            180                 185                 190         


Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu 
        195                 200                 205             


Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met 
    210                 215                 220                 


Cys Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys 
225                 230                 235                 240 


Ala Thr Ile Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala 
                245                 250                 255     


Gln Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly 
            260                 265                 270         


Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln 
        275                 280                 285             


Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro 
    290                 295                 300                 


Ala Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp 
305                 310                 315                 320 


Glu Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn 
                325                 330                 335     


Thr Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser 
            340                 345                 350         


Thr Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser 
        355                 360                 365             


Gly Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr 
    370                 375                 380                 


Lys Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr 
385                 390                 395                 400 


Ile Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu 
                405                 410                 415     


Cys Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser 
            420                 425                 430         


Arg Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly 
        435                 440                 445             


Asn Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly 
    450                 455                 460                 


Asn Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly 
465                 470                 475                 480 


Gln Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp 
                485                 490                 495     


Ile Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro 
            500                 505                 510         


Thr Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp 
        515                 520                 525             


Ala Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys 
    530                 535                 540                 


Thr Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys 
545                 550                 555                 560 


His Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile 
                565                 570                 575     


Asp Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val 
            580                 585                 590         


Asn Thr Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu 
        595                 600                 605             


Thr Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr 
    610                 615                 620                 


Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys 
625                 630                 635                 640 


Cys Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys 
                645                 650                 655     


Thr Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His 
            660                 665                 670         


Cys Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu 
        675                 680                 685             


Ala Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser 
    690                 695                 700                 


Thr Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro 
705                 710                 715                 720 


Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly 
                725                 730                 735     


Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe 
            740                 745                 750         


His Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp 
        755                 760                 765             


Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys 
    770                 775                 780                 


Glu Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu 
785                 790                 795                 800 


Pro Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val 
                805                 810                 815     


Asn Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser 
            820                 825                 830         


Tyr Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu 
        835                 840                 845             


Thr Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly 
    850                 855                 860                 


Ala Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly 
865                 870                 875                 880 


Ser Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly 
                885                 890                 895     


Thr Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn 
            900                 905                 910         


Gly Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp 
        915                 920                 925             


Gly Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly 
    930                 935                 940                 


Leu Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu 
945                 950                 955                 960 


Val Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly 
                965                 970                 975     


Ser Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly 
            980                 985                 990         


Arg Val Cys Leu Asp Ile Arg Met  Glu Gln Cys Tyr Leu  Lys Trp Asp 
        995                 1000                 1005             


Glu Asp  Glu Cys Ile His Pro  Val Pro Gly Lys Phe  Arg Met Asp 
    1010                 1015                 1020             


Ala Cys  Cys Cys Ala Val Gly  Ala Ala Trp Gly Thr  Glu Cys Glu 
    1025                 1030                 1035             


Glu Cys  Pro Lys Pro Gly Thr  Lys Glu Tyr Glu Thr  Leu Cys Pro 
    1040                 1045                 1050             


Arg Gly  Ala Gly Phe Ala Asn  Arg Gly Asp Val Leu  Thr Gly Arg 
    1055                 1060                 1065             


Pro Phe  Tyr Lys Asp Ile Asn  Glu Cys Lys Ala Phe  Pro Gly Met 
    1070                 1075                 1080             


Cys Thr  Tyr Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1085                 1090                 1095             


Arg Cys  Asn Ser Gly Phe Ala  Leu Asp Met Glu Glu  Arg Asn Cys 
    1100                 1105                 1110             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Ser 
    1115                 1120                 1125             


Gly Ile  Cys Val Asn Thr Pro  Gly Ser Phe Glu Cys  Glu Cys Phe 
    1130                 1135                 1140             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1145                 1150                 1155             


Ile Asp  Glu Cys Glu Arg Asn  Pro Leu Leu Cys Arg  Gly Gly Thr 
    1160                 1165                 1170             


Cys Val  Asn Thr Glu Gly Ser  Phe Gln Cys Asp Cys  Pro Leu Gly 
    1175                 1180                 1185             


His Glu  Leu Ser Pro Ser Arg  Glu Asp Cys Val Asp  Ile Asn Glu 
    1190                 1195                 1200             


Cys Ser  Leu Ser Asp Asn Leu  Cys Arg Asn Gly Lys  Cys Val Asn 
    1205                 1210                 1215             


Met Ile  Gly Thr Tyr Gln Cys  Ser Cys Asn Pro Gly  Tyr Gln Ala 
    1220                 1225                 1230             


Thr Pro  Asp Arg Gln Gly Cys  Thr Asp Ile Asp Glu  Cys Met Ile 
    1235                 1240                 1245             


Met Asn  Gly Gly Cys Asp Thr  Gln Cys Thr Asn Ser  Glu Gly Ser 
    1250                 1255                 1260             


Tyr Glu  Cys Ser Cys Ser Glu  Gly Tyr Ala Leu Met  Pro Asp Gly 
    1265                 1270                 1275             


Arg Ser  Cys Ala Asp Ile Asp  Glu Cys Glu Asn Asn  Pro Asp Ile 
    1280                 1285                 1290             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1295                 1300                 1305             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Met Asp Met  Lys Thr Cys 
    1310                 1315                 1320             


Ile Asp  Val Asn Glu Cys Asp  Leu Asn Ser Asn Ile  Cys Met Phe 
    1325                 1330                 1335             


Gly Glu  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Gln 
    1340                 1345                 1350             


Leu Gly  Tyr Ser Val Lys Lys  Gly Thr Thr Gly Cys  Thr Asp Val 
    1355                 1360                 1365             


Asp Glu  Cys Glu Ile Gly Ala  His Asn Cys Asp Met  His Ala Ser 
    1370                 1375                 1380             


Cys Leu  Asn Ile Pro Gly Ser  Phe Lys Cys Ser Cys  Arg Glu Gly 
    1385                 1390                 1395             


Trp Ile  Gly Asn Gly Ile Lys  Cys Ile Asp Leu Asp  Glu Cys Ser 
    1400                 1405                 1410             


Asn Gly  Thr His Gln Cys Ser  Ile Asn Ala Gln Cys  Val Asn Thr 
    1415                 1420                 1425             


Pro Gly  Ser Tyr Arg Cys Ala  Cys Ser Glu Gly Phe  Thr Gly Asp 
    1430                 1435                 1440             


Gly Phe  Thr Cys Ser Asp Val  Asp Glu Cys Ala Glu  Asn Ile Asn 
    1445                 1450                 1455             


Leu Cys  Glu Asn Gly Gln Cys  Leu Asn Val Pro Gly  Ala Tyr Arg 
    1460                 1465                 1470             


Cys Glu  Cys Glu Met Gly Phe  Thr Pro Ala Ser Asp  Ser Arg Ser 
    1475                 1480                 1485             


Cys Gln  Asp Ile Asp Glu Cys  Ser Phe Gln Asn Ile  Cys Val Phe 
    1490                 1495                 1500             


Gly Thr  Cys Asn Asn Leu Pro  Gly Met Phe His Cys  Ile Cys Asp 
    1505                 1510                 1515             


Asp Gly  Tyr Glu Leu Asp Arg  Thr Gly Gly Asn Cys  Thr Asp Ile 
    1520                 1525                 1530             


Asp Glu  Cys Ala Asp Pro Ile  Asn Cys Val Asn Gly  Leu Cys Val 
    1535                 1540                 1545             


Asn Thr  Pro Gly Arg Tyr Glu  Cys Asn Cys Pro Pro  Asp Phe Gln 
    1550                 1555                 1560             


Leu Asn  Pro Thr Gly Val Gly  Cys Val Asp Asn Arg  Val Gly Asn 
    1565                 1570                 1575             


Cys Tyr  Leu Lys Phe Gly Pro  Arg Gly Asp Gly Ser  Leu Ser Cys 
    1580                 1585                 1590             


Asn Thr  Glu Ile Gly Val Gly  Val Ser Arg Ser Ser  Cys Cys Cys 
    1595                 1600                 1605             


Ser Leu  Gly Lys Ala Trp Gly  Asn Pro Cys Glu Thr  Cys Pro Pro 
    1610                 1615                 1620             


Val Asn  Ser Thr Glu Tyr Tyr  Thr Leu Cys Pro Gly  Gly Glu Gly 
    1625                 1630                 1635             


Phe Arg  Pro Asn Pro Ile Thr  Ile Ile Leu Glu Asp  Ile Asp Glu 
    1640                 1645                 1650             


Cys Gln  Glu Leu Pro Gly Leu  Cys Gln Gly Gly Asn  Cys Ile Asn 
    1655                 1660                 1665             


Thr Phe  Gly Ser Phe Gln Cys  Glu Cys Pro Gln Gly  Tyr Tyr Leu 
    1670                 1675                 1680             


Ser Glu  Asp Thr Arg Ile Cys  Glu Asp Ile Asp Glu  Cys Phe Ala 
    1685                 1690                 1695             


His Pro  Gly Val Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Leu Gly 
    1700                 1705                 1710             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Glu Tyr Met Gln  Val Asn Gly 
    1715                 1720                 1725             


Gly His  Asn Cys Met Asp Met  Arg Lys Ser Phe Cys  Tyr Arg Ser 
    1730                 1735                 1740             


Tyr Asn  Gly Thr Thr Cys Glu  Asn Glu Leu Pro Phe  Asn Val Thr 
    1745                 1750                 1755             


Lys Arg  Met Cys Cys Cys Thr  Tyr Asn Val Gly Lys  Ala Trp Asn 
    1760                 1765                 1770             


Lys Pro  Cys Glu Pro Cys Pro  Thr Pro Gly Thr Ala  Asp Phe Lys 
    1775                 1780                 1785             


Thr Ile  Cys Gly Asn Ile Pro  Gly Phe Thr Phe Asp  Ile His Thr 
    1790                 1795                 1800             


Gly Lys  Ala Val Asp Ile Asp  Glu Cys Lys Glu Ile  Pro Gly Ile 
    1805                 1810                 1815             


Cys Ala  Asn Gly Val Cys Ile  Asn Gln Ile Gly Ser  Phe Arg Cys 
    1820                 1825                 1830             


Glu Cys  Pro Thr Gly Phe Ser  Tyr Asn Asp Leu Leu  Leu Val Cys 
    1835                 1840                 1845             


Glu Asp  Ile Asp Glu Cys Ser  Asn Gly Asp Asn Leu  Cys Gln Arg 
    1850                 1855                 1860             


Asn Ala  Asp Cys Ile Asn Ser  Pro Gly Ser Tyr Arg  Cys Glu Cys 
    1865                 1870                 1875             


Ala Ala  Gly Phe Lys Leu Ser  Pro Asn Gly Ala Cys  Val Asp Arg 
    1880                 1885                 1890             


Asn Glu  Cys Leu Glu Ile Pro  Asn Val Cys Ser His  Gly Leu Cys 
    1895                 1900                 1905             


Val Asp  Leu Gln Gly Ser Tyr  Gln Cys Ile Cys His  Asn Gly Phe 
    1910                 1915                 1920             


Lys Ala  Ser Gln Asp Gln Thr  Met Cys Met Asp Val  Asp Glu Cys 
    1925                 1930                 1935             


Glu Arg  His Pro Cys Gly Asn  Gly Thr Cys Lys Asn  Thr Val Gly 
    1940                 1945                 1950             


Ser Tyr  Asn Cys Leu Cys Tyr  Pro Gly Phe Glu Leu  Thr His Asn 
    1955                 1960                 1965             


Asn Asp  Cys Leu Asp Ile Asp  Glu Cys Ser Ser Phe  Phe Gly Gln 
    1970                 1975                 1980             


Val Cys  Arg Asn Gly Arg Cys  Phe Asn Glu Ile Gly  Ser Phe Lys 
    1985                 1990                 1995             


Cys Leu  Cys Asn Glu Gly Tyr  Glu Leu Thr Pro Asp  Gly Lys Asn 
    2000                 2005                 2010             


Cys Ile  Asp Thr Asn Glu Cys  Val Ala Leu Pro Gly  Ser Cys Ser 
    2015                 2020                 2025             


Pro Gly  Thr Cys Gln Asn Leu  Glu Gly Ser Phe Arg  Cys Ile Cys 
    2030                 2035                 2040             


Pro Pro  Gly Tyr Glu Val Lys  Ser Glu Asn Cys Ile  Asp Ile Asn 
    2045                 2050                 2055             


Glu Cys  Asp Glu Asp Pro Asn  Ile Cys Leu Phe Gly  Ser Cys Thr 
    2060                 2065                 2070             


Asn Thr  Pro Gly Gly Phe Gln  Cys Leu Cys Pro Pro  Gly Phe Val 
    2075                 2080                 2085             


Leu Ser  Asp Asn Gly Arg Arg  Cys Phe Asp Thr Arg  Gln Ser Phe 
    2090                 2095                 2100             


Cys Phe  Thr Asn Phe Glu Asn  Gly Lys Cys Ser Val  Pro Lys Ala 
    2105                 2110                 2115             


Phe Asn  Thr Thr Lys Ala Lys  Cys Cys Cys Ser Lys  Met Pro Gly 
    2120                 2125                 2130             


Glu Gly  Trp Gly Asp Pro Cys  Glu Leu Cys Pro Lys  Asp Asp Glu 
    2135                 2140                 2145             


Val Ala  Phe Gln Asp Leu Cys  Pro Tyr Gly His Gly  Thr Val Pro 
    2150                 2155                 2160             


Ser Leu  His Asp Thr Arg Glu  Asp Val Asn Glu Cys  Leu Glu Ser 
    2165                 2170                 2175             


Pro Gly  Ile Cys Ser Asn Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2180                 2185                 2190             


Phe Arg  Cys Glu Cys Pro Met  Gly Tyr Asn Leu Asp  Tyr Thr Gly 
    2195                 2200                 2205             


Val Arg  Cys Val Asp Thr Asp  Glu Cys Ser Ile Gly  Asn Pro Cys 
    2210                 2215                 2220             


Gly Asn  Gly Thr Cys Thr Asn  Val Ile Gly Ser Phe  Glu Cys Asn 
    2225                 2230                 2235             


Cys Asn  Glu Gly Phe Glu Pro  Gly Pro Met Met Asn  Cys Glu Asp 
    2240                 2245                 2250             


Ile Asn  Glu Cys Ala Gln Asn  Pro Leu Leu Cys Ala  Phe Arg Cys 
    2255                 2260                 2265             


Met Asn  Thr Phe Gly Ser Tyr  Glu Cys Thr Cys Pro  Ile Gly Tyr 
    2270                 2275                 2280             


Ala Leu  Arg Glu Asp Gln Lys  Met Cys Lys Asp Leu  Asp Glu Cys 
    2285                 2290                 2295             


Ala Glu  Gly Leu His Asp Cys  Glu Ser Arg Gly Met  Met Cys Lys 
    2300                 2305                 2310             


Asn Leu  Ile Gly Thr Phe Met  Cys Ile Cys Pro Pro  Gly Met Ala 
    2315                 2320                 2325             


Arg Arg  Pro Asp Gly Glu Gly  Cys Val Asp Glu Asn  Glu Cys Arg 
    2330                 2335                 2340             


Thr Lys  Pro Gly Ile Cys Glu  Asn Gly Arg Cys Val  Asn Ile Ile 
    2345                 2350                 2355             


Gly Ser  Tyr Arg Cys Glu Cys  Asn Glu Gly Phe Gln  Ser Ser Ser 
    2360                 2365                 2370             


Ser Gly  Thr Glu Cys Leu Asp  Asn Arg Gln Gly Leu  Cys Phe Ala 
    2375                 2380                 2385             


Glu Val  Leu Gln Thr Ile Cys  Gln Met Ala Ser Ser  Ser Arg Asn 
    2390                 2395                 2400             


Leu Val  Thr Lys Ser Glu Cys  Cys Cys Asp Gly Gly  Arg Gly Trp 
    2405                 2410                 2415             


Gly His  Gln Cys Glu Leu Cys  Pro Leu Pro Gly Thr  Ala Gln Tyr 
    2420                 2425                 2430             


Lys Lys  Ile Cys Pro His Gly  Pro Gly Tyr Thr Thr  Asp Gly Arg 
    2435                 2440                 2445             


Asp Ile  Asp Glu Cys Lys Val  Met Pro Asn Leu Cys  Thr Asn Gly 
    2450                 2455                 2460             


Gln Cys  Ile Asn Thr Met Gly  Ser Phe Arg Cys Phe  Cys Lys Val 
    2465                 2470                 2475             


Gly Tyr  Thr Thr Asp Ile Ser  Gly Thr Ser Cys Ile  Asp Leu Asp 
    2480                 2485                 2490             


Glu Cys  Ser Gln Ser Pro Lys  Pro Cys Asn Tyr Ile  Cys Lys Asn 
    2495                 2500                 2505             


Thr Glu  Gly Ser Tyr Gln Cys  Ser Cys Pro Arg Gly  Tyr Val Leu 
    2510                 2515                 2520             


Gln Glu  Asp Gly Lys Thr Cys  Lys Asp Leu Asp Glu  Cys Gln Thr 
    2525                 2530                 2535             


Lys Gln  His Asn Cys Gln Phe  Leu Cys Val Asn Thr  Leu Gly Gly 
    2540                 2545                 2550             


Phe Thr  Cys Lys Cys Pro Pro  Gly Phe Thr Gln His  His Thr Ala 
    2555                 2560                 2565             


Cys Ile  Asp Asn Asn Glu Cys  Gly Ser Gln Pro Ser  Leu Cys Gly 
    2570                 2575                 2580             


Ala Lys  Gly Ile Cys Gln Asn  Thr Pro Gly Ser Phe  Ser Cys Glu 
    2585                 2590                 2595             


Cys Gln  Arg Gly Phe Ser Leu  Asp Ala Thr Gly Leu  Asn Cys Glu 
    2600                 2605                 2610             


Asp Val  Asp Glu Cys Asp Gly  Asn His Arg Cys Gln  His Gly Cys 
    2615                 2620                 2625             


Gln Asn  Ile Leu Gly Gly Tyr  Arg Cys Gly Cys Pro  Gln Gly Tyr 
    2630                 2635                 2640             


Ile Gln  His Tyr Gln Trp Asn  Gln Cys Val Asp Glu  Asn Glu Cys 
    2645                 2650                 2655             


Ser Asn  Pro Asn Ala Cys Gly  Ser Ala Ser Cys Tyr  Asn Thr Leu 
    2660                 2665                 2670             


Gly Ser  Tyr Lys Cys Ala Cys  Pro Ser Gly Phe Ser  Phe Asp Gln 
    2675                 2680                 2685             


Phe Ser  Ser Ala Cys His Asp  Val Asn Glu Cys Ser  Ser Ser Lys 
    2690                 2695                 2700             


Asn Pro  Cys Asn Tyr Gly Cys  Ser Asn Thr Glu Gly  Gly Tyr Leu 
    2705                 2710                 2715             


Cys Gly  Cys Pro Pro Gly Tyr  Tyr Arg Val Gly Gln  Gly His Cys 
    2720                 2725                 2730             


Val Ser  Gly Met Gly Phe Asn  Lys Gly Gln Tyr Leu  Ser Leu Asp 
    2735                 2740                 2745             


Thr Glu  Val Asp Glu Glu Asn  Ala Leu Ser Pro Glu  Ala Cys Tyr 
    2750                 2755                 2760             


Glu Cys  Lys Ile Asn Gly Tyr  Ser Lys Lys Asp Ser  Arg Gln Lys 
    2765                 2770                 2775             


Arg Ser  Ile His Glu Pro Asp  Pro Thr Ala Val Glu  Gln Ile Ser 
    2780                 2785                 2790             


Leu Glu  Ser Val Asp Met Asp  Ser Pro Val Asn Met  Lys Phe Asn 
    2795                 2800                 2805             


Leu Ser  His Leu Gly Ser Lys  Glu His Ile Leu Glu  Leu Arg Pro 
    2810                 2815                 2820             


Ala Ile  Gln Pro Leu Asn Asn  His Ile Arg Tyr Val  Ile Ser Gln 
    2825                 2830                 2835             


Gly Asn  Asp Asp Ser Val Phe  Arg Ile His Gln Arg  Asn Gly Leu 
    2840                 2845                 2850             


Ser Tyr  Leu His Thr Ala Lys  Lys Lys Leu Met Pro  Gly Thr Tyr 
    2855                 2860                 2865             


Thr Leu  Glu Ile Thr Ser Ile  Pro Leu Tyr Lys Lys  Lys Glu Leu 
    2870                 2875                 2880             


Lys Lys  Leu Glu Glu Ser Asn  Glu Asp Asp Tyr Leu  Leu Gly Glu 
    2885                 2890                 2895             


Leu Gly  Glu Ala Leu Arg Met  Arg Leu Gln Ile Gln  Leu Tyr 
    2900                 2905                 2910         


<210>  3918
<211>  2809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBN3__Homo_sapiens__NP_115823

<400>  3918

Met Thr Leu Glu Gly Leu Tyr Leu Ala Arg Gly Pro Leu Ala Arg Leu 
1               5                   10                  15      


Leu Leu Ala Trp Ser Ala Leu Leu Cys Met Ala Gly Gly Gln Gly Arg 
            20                  25                  30          


Trp Asp Gly Ala Leu Glu Ala Ala Gly Pro Gly Arg Val Arg Arg Arg 
        35                  40                  45              


Gly Ser Pro Gly Ile Leu Gln Gly Pro Asn Val Cys Gly Ser Arg Phe 
    50                  55                  60                  


His Ala Tyr Cys Cys Pro Gly Trp Arg Thr Phe Pro Gly Arg Ser Gln 
65                  70                  75                  80  


Cys Val Val Pro Ile Cys Arg Arg Ala Cys Gly Glu Gly Phe Cys Ser 
                85                  90                  95      


Gln Pro Asn Leu Cys Thr Cys Ala Asp Gly Thr Leu Ala Pro Ser Cys 
            100                 105                 110         


Gly Val Ser Arg Gly Ser Gly Cys Ser Val Ser Cys Met Asn Gly Gly 
        115                 120                 125             


Thr Cys Arg Gly Ala Ser Cys Leu Cys Gln Lys Gly Tyr Thr Gly Thr 
    130                 135                 140                 


Val Cys Gly Gln Pro Ile Cys Asp Arg Gly Cys His Asn Gly Gly Arg 
145                 150                 155                 160 


Cys Ile Gly Pro Asn Arg Cys Ala Cys Val Tyr Gly Phe Met Gly Pro 
                165                 170                 175     


Gln Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Gly Gln Val Gly 
            180                 185                 190         


Pro Glu Gly Cys Gln His Gln Leu Thr Gly Leu Val Cys Thr Lys Ala 
        195                 200                 205             


Leu Cys Cys Ala Thr Val Gly Arg Ala Trp Gly Leu Pro Cys Glu Leu 
    210                 215                 220                 


Cys Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile 
225                 230                 235                 240 


His Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Val Pro Gly 
                245                 250                 255     


Leu Cys Gln Gly Gly Ser Cys Val Asn Met Val Gly Ser Phe His Cys 
            260                 265                 270         


Arg Cys Pro Val Gly His Arg Leu Ser Asp Ser Ser Ala Ala Cys Glu 
        275                 280                 285             


Asp Tyr Arg Ala Gly Ala Cys Phe Ser Val Leu Phe Gly Gly Arg Cys 
    290                 295                 300                 


Ala Gly Asp Leu Ala Gly His Tyr Thr Arg Arg Gln Cys Cys Cys Asp 
305                 310                 315                 320 


Arg Gly Arg Cys Trp Ala Ala Gly Pro Val Pro Glu Leu Cys Pro Pro 
                325                 330                 335     


Arg Gly Ser Asn Glu Phe Gln Gln Leu Cys Ala Gln Arg Leu Pro Leu 
            340                 345                 350         


Leu Pro Gly His Pro Gly Leu Phe Pro Gly Leu Leu Gly Phe Gly Ser 
        355                 360                 365             


Asn Gly Met Gly Pro Pro Leu Gly Pro Ala Arg Leu Asn Pro His Gly 
    370                 375                 380                 


Ser Asp Ala Arg Gly Ile Pro Ser Leu Gly Pro Gly Asn Ser Asn Ile 
385                 390                 395                 400 


Gly Thr Ala Thr Leu Asn Gln Thr Ile Asp Ile Cys Arg His Phe Thr 
                405                 410                 415     


Asn Leu Cys Leu Asn Gly Arg Cys Leu Pro Thr Pro Ser Ser Tyr Arg 
            420                 425                 430         


Cys Glu Cys Asn Val Gly Tyr Thr Gln Asp Val Arg Gly Glu Cys Ile 
        435                 440                 445             


Asp Val Asp Glu Cys Thr Ser Ser Pro Cys His His Gly Asp Cys Val 
    450                 455                 460                 


Asn Ile Pro Gly Thr Tyr His Cys Arg Cys Tyr Pro Gly Phe Gln Ala 
465                 470                 475                 480 


Thr Pro Thr Arg Gln Ala Cys Val Asp Val Asp Glu Cys Ile Val Ser 
                485                 490                 495     


Gly Gly Leu Cys His Leu Gly Arg Cys Val Asn Thr Glu Gly Ser Phe 
            500                 505                 510         


Gln Cys Val Cys Asn Ala Gly Phe Glu Leu Ser Pro Asp Gly Lys Asn 
        515                 520                 525             


Cys Val Asp His Asn Glu Cys Ala Thr Ser Thr Met Cys Val Asn Gly 
    530                 535                 540                 


Val Cys Leu Asn Glu Asp Gly Ser Phe Ser Cys Leu Cys Lys Pro Gly 
545                 550                 555                 560 


Phe Leu Leu Ala Pro Gly Gly His Tyr Cys Met Asp Ile Asp Glu Cys 
                565                 570                 575     


Gln Thr Pro Gly Ile Cys Val Asn Gly His Cys Thr Asn Thr Glu Gly 
            580                 585                 590         


Ser Phe Arg Cys Gln Cys Leu Gly Gly Leu Ala Val Gly Thr Asp Gly 
        595                 600                 605             


Arg Val Cys Val Asp Thr His Val Arg Ser Thr Cys Tyr Gly Ala Ile 
    610                 615                 620                 


Glu Lys Gly Ser Cys Ala Arg Pro Phe Pro Gly Thr Val Thr Lys Ser 
625                 630                 635                 640 


Glu Cys Cys Cys Ala Asn Pro Asp His Gly Phe Gly Glu Pro Cys Gln 
                645                 650                 655     


Leu Cys Pro Ala Lys Asp Ser Ala Glu Phe Gln Ala Leu Cys Ser Ser 
            660                 665                 670         


Gly Leu Gly Ile Thr Thr Asp Gly Arg Asp Ile Asn Glu Cys Ala Leu 
        675                 680                 685             


Asp Pro Glu Val Cys Ala Asn Gly Val Cys Glu Asn Leu Arg Gly Ser 
    690                 695                 700                 


Tyr Arg Cys Val Cys Asn Leu Gly Tyr Glu Ala Gly Ala Ser Gly Lys 
705                 710                 715                 720 


Asp Cys Thr Asp Val Asp Glu Cys Ala Leu Asn Ser Leu Leu Cys Asp 
                725                 730                 735     


Asn Gly Trp Cys Gln Asn Ser Pro Gly Ser Tyr Ser Cys Ser Cys Pro 
            740                 745                 750         


Pro Gly Phe His Phe Trp Gln Asp Thr Glu Ile Cys Lys Asp Val Asp 
        755                 760                 765             


Glu Cys Leu Ser Ser Pro Cys Val Ser Gly Val Cys Arg Asn Leu Ala 
    770                 775                 780                 


Gly Ser Tyr Thr Cys Lys Cys Gly Pro Gly Ser Arg Leu Asp Pro Ser 
785                 790                 795                 800 


Gly Thr Phe Cys Leu Asp Ser Thr Lys Gly Thr Cys Trp Leu Lys Ile 
                805                 810                 815     


Gln Glu Ser Arg Cys Glu Val Asn Leu Gln Gly Ala Ser Leu Arg Ser 
            820                 825                 830         


Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser Pro Cys Glu Arg 
        835                 840                 845             


Cys Glu Ile Asp Pro Ala Cys Ala Arg Gly Phe Ala Arg Met Thr Gly 
    850                 855                 860                 


Val Thr Cys Asp Asp Val Asn Glu Cys Glu Ser Phe Pro Gly Val Cys 
865                 870                 875                 880 


Pro Asn Gly Arg Cys Val Asn Thr Ala Gly Ser Phe Arg Cys Glu Cys 
                885                 890                 895     


Pro Glu Gly Leu Met Leu Asp Ala Ser Gly Arg Leu Cys Val Asp Val 
            900                 905                 910         


Arg Leu Glu Pro Cys Phe Leu Arg Trp Asp Glu Asp Glu Cys Gly Val 
        915                 920                 925             


Thr Leu Pro Gly Lys Tyr Arg Met Asp Val Cys Cys Cys Ser Ile Gly 
    930                 935                 940                 


Ala Val Trp Gly Val Glu Cys Glu Ala Cys Pro Asp Pro Glu Ser Leu 
945                 950                 955                 960 


Glu Phe Ala Ser Leu Cys Pro Arg Gly Leu Gly Phe Ala Ser Arg Asp 
                965                 970                 975     


Phe Leu Ser Gly Arg Pro Phe Tyr Lys Asp Val Asn Glu Cys Lys Val 
            980                 985                 990         


Phe Pro Gly Leu Cys Thr His Gly  Thr Cys Arg Asn Thr  Val Gly Ser 
        995                 1000                 1005             


Phe His  Cys Ala Cys Ala Gly  Gly Phe Ala Leu Asp  Ala Gln Glu 
    1010                 1015                 1020             


Arg Asn  Cys Thr Asp Ile Asp  Glu Cys Arg Ile Ser  Pro Asp Leu 
    1025                 1030                 1035             


Cys Gly  Gln Gly Thr Cys Val  Asn Thr Pro Gly Ser  Phe Glu Cys 
    1040                 1045                 1050             


Glu Cys  Phe Pro Gly Tyr Glu  Ser Gly Phe Met Leu  Met Lys Asn 
    1055                 1060                 1065             


Cys Met  Asp Val Asp Glu Cys  Ala Arg Asp Pro Leu  Leu Cys Arg 
    1070                 1075                 1080             


Gly Gly  Thr Cys Thr Asn Thr  Asp Gly Ser Tyr Lys  Cys Gln Cys 
    1085                 1090                 1095             


Pro Pro  Gly His Glu Leu Thr  Ala Lys Gly Thr Ala  Cys Glu Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Ser Leu Ser  Asp Gly Leu Cys Pro  His Gly Gln 
    1115                 1120                 1125             


Cys Val  Asn Val Ile Gly Ala  Phe Gln Cys Ser Cys  His Ala Gly 
    1130                 1135                 1140             


Phe Gln  Ser Thr Pro Asp Arg  Gln Gly Cys Val Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Arg  Val Gln Asn Gly Gly  Cys Asp Val His Cys  Ile Asn Thr 
    1160                 1165                 1170             


Glu Gly  Ser Tyr Arg Cys Ser  Cys Gly Gln Gly Tyr  Ser Leu Met 
    1175                 1180                 1185             


Pro Asp  Gly Arg Ala Cys Ala  Asp Val Asp Glu Cys  Glu Glu Asn 
    1190                 1195                 1200             


Pro Arg  Val Cys Asp Gln Gly  His Cys Thr Asn Met  Pro Gly Gly 
    1205                 1210                 1215             


His Arg  Cys Leu Cys Tyr Asp  Gly Phe Met Ala Thr  Pro Asp Met 
    1220                 1225                 1230             


Arg Thr  Cys Val Asp Val Asp  Glu Cys Asp Leu Asn  Pro His Ile 
    1235                 1240                 1245             


Cys Leu  His Gly Asp Cys Glu  Asn Thr Lys Gly Ser  Phe Val Cys 
    1250                 1255                 1260             


His Cys  Gln Leu Gly Tyr Met  Val Arg Lys Gly Ala  Thr Gly Cys 
    1265                 1270                 1275             


Ser Asp  Val Asp Glu Cys Glu  Val Gly Gly His Asn  Cys Asp Ser 
    1280                 1285                 1290             


His Ala  Ser Cys Leu Asn Ile  Pro Gly Ser Phe Ser  Cys Arg Cys 
    1295                 1300                 1305             


Leu Pro  Gly Trp Val Gly Asp  Gly Phe Glu Cys His  Asp Leu Asp 
    1310                 1315                 1320             


Glu Cys  Val Ser Gln Glu His  Arg Cys Ser Pro Arg  Gly Asp Cys 
    1325                 1330                 1335             


Leu Asn  Val Pro Gly Ser Tyr  Arg Cys Thr Cys Arg  Gln Gly Phe 
    1340                 1345                 1350             


Ala Gly  Asp Gly Phe Phe Cys  Glu Asp Arg Asp Glu  Cys Ala Glu 
    1355                 1360                 1365             


Asn Val  Asp Leu Cys Asp Asn  Gly Gln Cys Leu Asn  Ala Pro Gly 
    1370                 1375                 1380             


Gly Tyr  Arg Cys Glu Cys Glu  Met Gly Phe Asp Pro  Thr Glu Asp 
    1385                 1390                 1395             


His Arg  Ala Cys Gln Asp Val  Asp Glu Cys Ala Gln  Gly Asn Leu 
    1400                 1405                 1410             


Cys Ala  Phe Gly Ser Cys Glu  Asn Leu Pro Gly Met  Phe Arg Cys 
    1415                 1420                 1425             


Ile Cys  Asn Gly Gly Tyr Glu  Leu Asp Arg Gly Gly  Gly Asn Cys 
    1430                 1435                 1440             


Thr Asp  Ile Asn Glu Cys Ala  Asp Pro Val Asn Cys  Ile Asn Gly 
    1445                 1450                 1455             


Val Cys  Ile Asn Thr Pro Gly  Ser Tyr Leu Cys Ser  Cys Pro Gln 
    1460                 1465                 1470             


Asp Phe  Glu Leu Asn Pro Ser  Gly Val Gly Cys Val  Asp Thr Arg 
    1475                 1480                 1485             


Ala Gly  Asn Cys Phe Leu Glu  Thr His Asp Arg Gly  Asp Ser Gly 
    1490                 1495                 1500             


Ile Ser  Cys Ser Ala Glu Ile  Gly Val Gly Val Thr  Arg Ala Ser 
    1505                 1510                 1515             


Cys Cys  Cys Ser Leu Gly Arg  Ala Trp Gly Asn Pro  Cys Glu Leu 
    1520                 1525                 1530             


Cys Pro  Met Ala Asn Thr Thr  Glu Tyr Arg Thr Leu  Cys Pro Gly 
    1535                 1540                 1545             


Gly Glu  Gly Phe Gln Pro Asn  Arg Ile Thr Val Ile  Leu Glu Asp 
    1550                 1555                 1560             


Ile Asp  Glu Cys Gln Glu Leu  Pro Gly Leu Cys Gln  Gly Gly Asp 
    1565                 1570                 1575             


Cys Val  Asn Thr Phe Gly Ser  Phe Gln Cys Glu Cys  Pro Pro Gly 
    1580                 1585                 1590             


Tyr His  Leu Ser Glu His Thr  Arg Ile Cys Glu Asp  Ile Asp Glu 
    1595                 1600                 1605             


Cys Ser  Thr His Ser Gly Ile  Cys Gly Pro Gly Thr  Cys Tyr Asn 
    1610                 1615                 1620             


Thr Leu  Gly Asn Tyr Thr Cys  Val Cys Pro Ala Glu  Tyr Leu Gln 
    1625                 1630                 1635             


Val Asn  Gly Gly Asn Asn Cys  Met Asp Met Arg Lys  Ser Val Cys 
    1640                 1645                 1650             


Phe Arg  His Tyr Asn Gly Thr  Cys Gln Asn Glu Leu  Ala Phe Asn 
    1655                 1660                 1665             


Val Thr  Arg Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Gln Ala 
    1670                 1675                 1680             


Trp Asn  Arg Pro Cys Glu Ala  Cys Pro Thr Pro Ile  Ser Pro Asp 
    1685                 1690                 1695             


Tyr Gln  Ile Leu Cys Gly Asn  Gln Ala Pro Gly Phe  Leu Thr Asp 
    1700                 1705                 1710             


Ile His  Thr Gly Lys Pro Leu  Asp Ile Asp Glu Cys  Gly Glu Ile 
    1715                 1720                 1725             


Pro Ala  Ile Cys Ala Asn Gly  Ile Cys Ile Asn Gln  Ile Gly Ser 
    1730                 1735                 1740             


Phe Arg  Cys Glu Cys Pro Ala  Gly Phe Asn Tyr Asn  Ser Ile Leu 
    1745                 1750                 1755             


Leu Ala  Cys Glu Asp Val Asp  Glu Cys Gly Ser Arg  Glu Ser Pro 
    1760                 1765                 1770             


Cys Gln  Gln Asn Ala Asp Cys  Ile Asn Ile Pro Gly  Ser Tyr Arg 
    1775                 1780                 1785             


Cys Lys  Cys Thr Arg Gly Tyr  Lys Leu Ser Pro Gly  Gly Ala Cys 
    1790                 1795                 1800             


Val Gly  Arg Asn Glu Cys Arg  Glu Ile Pro Asn Val  Cys Ser His 
    1805                 1810                 1815             


Gly Asp  Cys Met Asp Thr Glu  Gly Ser Tyr Met Cys  Leu Cys His 
    1820                 1825                 1830             


Arg Gly  Phe Gln Ala Ser Ala  Asp Gln Thr Leu Cys  Met Asp Ile 
    1835                 1840                 1845             


Asp Glu  Cys Asp Arg Gln Pro  Cys Gly Asn Gly Thr  Cys Lys Asn 
    1850                 1855                 1860             


Ile Ile  Gly Ser Tyr Asn Cys  Leu Cys Phe Pro Gly  Phe Val Val 
    1865                 1870                 1875             


Thr His  Asn Gly Asp Cys Val  Asp Phe Asp Glu Cys  Thr Thr Leu 
    1880                 1885                 1890             


Val Gly  Gln Val Cys Arg Phe  Gly His Cys Leu Asn  Thr Ala Gly 
    1895                 1900                 1905             


Ser Phe  His Cys Leu Cys Gln  Asp Gly Phe Glu Leu  Thr Ala Asp 
    1910                 1915                 1920             


Gly Lys  Asn Cys Val Asp Thr  Asn Glu Cys Leu Ser  Leu Ala Gly 
    1925                 1930                 1935             


Thr Cys  Leu Pro Gly Thr Cys  Gln Asn Leu Glu Gly  Ser Phe Arg 
    1940                 1945                 1950             


Cys Ile  Cys Pro Pro Gly Phe  Gln Val Gln Ser Asp  His Cys Ile 
    1955                 1960                 1965             


Asp Ile  Asp Glu Cys Ser Glu  Glu Pro Asn Leu Cys  Leu Phe Gly 
    1970                 1975                 1980             


Thr Cys  Thr Asn Ser Pro Gly  Ser Phe Gln Cys Leu  Cys Pro Pro 
    1985                 1990                 1995             


Gly Phe  Val Leu Ser Asp Asn  Gly His Arg Cys Phe  Asp Thr Arg 
    2000                 2005                 2010             


Gln Ser  Phe Cys Phe Thr Arg  Phe Glu Ala Gly Lys  Cys Ser Val 
    2015                 2020                 2025             


Pro Lys  Ala Phe Asn Thr Thr  Lys Thr Arg Cys Cys  Cys Ser Lys 
    2030                 2035                 2040             


Arg Pro  Gly Glu Gly Trp Gly  Asp Pro Cys Glu Leu  Cys Pro Gln 
    2045                 2050                 2055             


Glu Gly  Ser Ala Ala Phe Gln  Glu Leu Cys Pro Phe  Gly His Gly 
    2060                 2065                 2070             


Ala Val  Pro Gly Pro Asp Asp  Ser Arg Glu Asp Val  Asn Glu Cys 
    2075                 2080                 2085             


Ala Glu  Asn Pro Gly Val Cys  Thr Asn Gly Val Cys  Val Asn Thr 
    2090                 2095                 2100             


Asp Gly  Ser Phe Arg Cys Glu  Cys Pro Phe Gly Tyr  Ser Leu Asp 
    2105                 2110                 2115             


Phe Thr  Gly Ile Asn Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly 
    2120                 2125                 2130             


His Pro  Cys Gly Gln Gly Thr  Cys Thr Asn Val Ile  Gly Gly Phe 
    2135                 2140                 2145             


Glu Cys  Ala Cys Ala Asp Gly  Phe Glu Pro Gly Leu  Met Met Thr 
    2150                 2155                 2160             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Asn Pro Leu  Leu Cys Ala 
    2165                 2170                 2175             


Phe Arg  Cys His Asn Thr Glu  Gly Ser Tyr Leu Cys  Thr Cys Pro 
    2180                 2185                 2190             


Ala Gly  Tyr Thr Leu Arg Glu  Asp Gly Ala Met Cys  Arg Asp Val 
    2195                 2200                 2205             


Asp Glu  Cys Ala Asp Gly Gln  Gln Asp Cys His Ala  Arg Gly Met 
    2210                 2215                 2220             


Glu Cys  Lys Asn Leu Ile Gly  Thr Phe Ala Cys Val  Cys Pro Pro 
    2225                 2230                 2235             


Gly Met  Arg Pro Leu Pro Gly  Ser Gly Glu Gly Cys  Thr Asp Asp 
    2240                 2245                 2250             


Asn Glu  Cys His Ala Gln Pro  Asp Leu Cys Val Asn  Gly Arg Cys 
    2255                 2260                 2265             


Val Asn  Thr Ala Gly Ser Phe  Arg Cys Asp Cys Asp  Glu Gly Phe 
    2270                 2275                 2280             


Gln Pro  Ser Pro Thr Leu Thr  Glu Cys His Asp Ile  Arg Gln Gly 
    2285                 2290                 2295             


Pro Cys  Phe Ala Glu Val Leu  Gln Thr Met Cys Arg  Ser Leu Ser 
    2300                 2305                 2310             


Ser Ser  Ser Glu Ala Val Thr  Arg Ala Glu Cys Cys  Cys Gly Gly 
    2315                 2320                 2325             


Gly Arg  Gly Trp Gly Pro Arg  Cys Glu Leu Cys Pro  Leu Pro Gly 
    2330                 2335                 2340             


Thr Ser  Ala Tyr Arg Lys Leu  Cys Pro His Gly Ser  Gly Tyr Thr 
    2345                 2350                 2355             


Ala Glu  Gly Arg Asp Val Asp  Glu Cys Arg Met Leu  Ala His Leu 
    2360                 2365                 2370             


Cys Ala  His Gly Glu Cys Ile  Asn Ser Leu Gly Ser  Phe Arg Cys 
    2375                 2380                 2385             


His Cys  Gln Ala Gly Tyr Thr  Pro Asp Ala Thr Ala  Thr Thr Cys 
    2390                 2395                 2400             


Leu Asp  Met Asp Glu Cys Ser  Gln Val Pro Lys Pro  Cys Thr Phe 
    2405                 2410                 2415             


Leu Cys  Lys Asn Thr Lys Gly  Ser Phe Leu Cys Ser  Cys Pro Arg 
    2420                 2425                 2430             


Gly Tyr  Leu Leu Glu Glu Asp  Gly Arg Thr Cys Lys  Asp Leu Asp 
    2435                 2440                 2445             


Glu Cys  Thr Ser Arg Gln His  Asn Cys Gln Phe Leu  Cys Val Asn 
    2450                 2455                 2460             


Thr Val  Gly Ala Phe Thr Cys  Arg Cys Pro Pro Gly  Phe Thr Gln 
    2465                 2470                 2475             


His His  Gln Ala Cys Phe Asp  Asn Asp Glu Cys Ser  Ala Gln Pro 
    2480                 2485                 2490             


Gly Pro  Cys Gly Ala His Gly  His Cys His Asn Thr  Pro Gly Ser 
    2495                 2500                 2505             


Phe Arg  Cys Glu Cys His Gln  Gly Phe Thr Leu Val  Ser Ser Gly 
    2510                 2515                 2520             


His Gly  Cys Glu Asp Val Asn  Glu Cys Asp Gly Pro  His Arg Cys 
    2525                 2530                 2535             


Gln His  Gly Cys Gln Asn Gln  Leu Gly Gly Tyr Arg  Cys Ser Cys 
    2540                 2545                 2550             


Pro Gln  Gly Phe Thr Gln His  Ser Gln Trp Ala Gln  Cys Val Asp 
    2555                 2560                 2565             


Glu Asn  Glu Cys Ala Leu Ser  Pro Pro Thr Cys Gly  Ser Ala Ser 
    2570                 2575                 2580             


Cys Arg  Asn Thr Leu Gly Gly  Phe Arg Cys Val Cys  Pro Ser Gly 
    2585                 2590                 2595             


Phe Asp  Phe Asp Gln Ala Leu  Gly Gly Cys Gln Glu  Val Asp Glu 
    2600                 2605                 2610             


Cys Ala  Gly Arg Arg Gly Pro  Cys Ser Tyr Ser Cys  Ala Asn Thr 
    2615                 2620                 2625             


Pro Gly  Gly Phe Leu Cys Gly  Cys Pro Gln Gly Tyr  Phe Arg Ala 
    2630                 2635                 2640             


Gly Gln  Gly His Cys Val Ser  Gly Leu Gly Phe Ser  Pro Gly Pro 
    2645                 2650                 2655             


Gln Asp  Thr Pro Asp Lys Glu  Glu Leu Leu Ser Ser  Glu Ala Cys 
    2660                 2665                 2670             


Tyr Glu  Cys Lys Ile Asn Gly  Leu Ser Pro Arg Asp  Arg Pro Arg 
    2675                 2680                 2685             


Arg Ser  Ala His Arg Asp His  Gln Val Asn Leu Ala  Thr Leu Asp 
    2690                 2695                 2700             


Ser Glu  Ala Leu Leu Thr Leu  Gly Leu Asn Leu Ser  His Leu Gly 
    2705                 2710                 2715             


Arg Ala  Glu Arg Ile Leu Glu  Leu Arg Pro Ala Leu  Glu Gly Leu 
    2720                 2725                 2730             


Glu Gly  Arg Ile Arg Tyr Val  Ile Val Arg Gly Asn  Glu Gln Gly 
    2735                 2740                 2745             


Phe Phe  Arg Met His His Leu  Arg Gly Val Ser Ser  Leu Gln Leu 
    2750                 2755                 2760             


Gly Arg  Arg Arg Pro Gly Pro  Gly Thr Tyr Arg Leu  Glu Val Val 
    2765                 2770                 2775             


Ser His  Met Ala Gly Pro Trp  Gly Val Gln Pro Glu  Gly Gln Pro 
    2780                 2785                 2790             


Gly Pro  Trp Gly Gln Ala Leu  Arg Leu Lys Val Gln  Leu Gln Leu 
    2795                 2800                 2805             


Leu 
    


<210>  3919
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBP1__Homo_sapiens__NP_000498

<400>  3919

Met Ala Asp Gln Ala Pro Phe Asp Thr Asp Val Asn Thr Leu Thr Arg 
1               5                   10                  15      


Phe Val Met Glu Glu Gly Arg Lys Ala Arg Gly Thr Gly Glu Leu Thr 
            20                  25                  30          


Gln Leu Leu Asn Ser Leu Cys Thr Ala Val Lys Ala Ile Ser Ser Ala 
        35                  40                  45              


Val Arg Lys Ala Gly Ile Ala His Leu Tyr Gly Ile Ala Gly Ser Thr 
    50                  55                  60                  


Asn Val Thr Gly Asp Gln Val Lys Lys Leu Asp Val Leu Ser Asn Asp 
65                  70                  75                  80  


Leu Val Met Asn Met Leu Lys Ser Ser Phe Ala Thr Cys Val Leu Val 
                85                  90                  95      


Ser Glu Glu Asp Lys His Ala Ile Ile Val Glu Pro Glu Lys Arg Gly 
            100                 105                 110         


Lys Tyr Val Val Cys Phe Asp Pro Leu Asp Gly Ser Ser Asn Ile Asp 
        115                 120                 125             


Cys Leu Val Ser Val Gly Thr Ile Phe Gly Ile Tyr Arg Lys Lys Ser 
    130                 135                 140                 


Thr Asp Glu Pro Ser Glu Lys Asp Ala Leu Gln Pro Gly Arg Asn Leu 
145                 150                 155                 160 


Val Ala Ala Gly Tyr Ala Leu Tyr Gly Ser Ala Thr Met Leu Val Leu 
                165                 170                 175     


Ala Met Asp Cys Gly Val Asn Cys Phe Met Leu Asp Pro Ala Ile Gly 
            180                 185                 190         


Glu Phe Ile Leu Val Asp Lys Asp Val Lys Ile Lys Lys Lys Gly Lys 
        195                 200                 205             


Ile Tyr Ser Leu Asn Glu Gly Tyr Ala Arg Asp Phe Asp Pro Ala Val 
    210                 215                 220                 


Thr Glu Tyr Ile Gln Arg Lys Lys Phe Pro Pro Asp Asn Ser Ala Pro 
225                 230                 235                 240 


Tyr Gly Ala Arg Tyr Val Gly Ser Met Val Ala Asp Val His Arg Thr 
                245                 250                 255     


Leu Val Tyr Gly Gly Ile Phe Leu Tyr Pro Ala Asn Lys Lys Ser Pro 
            260                 265                 270         


Asn Gly Lys Leu Arg Leu Leu Tyr Glu Cys Asn Pro Met Ala Tyr Val 
        275                 280                 285             


Met Glu Lys Ala Gly Gly Met Ala Thr Thr Gly Lys Glu Ala Val Leu 
    290                 295                 300                 


Asp Val Ile Pro Thr Asp Ile His Gln Arg Ala Pro Val Ile Leu Gly 
305                 310                 315                 320 


Ser Pro Asp Asp Val Leu Glu Phe Leu Lys Val Tyr Glu Lys His Ser 
                325                 330                 335     


Ala Gln 
        


<210>  3920
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBP2__Homo_sapiens__NP_003828

<400>  3920

Met Thr Asp Arg Ser Pro Phe Glu Thr Asp Met Leu Thr Leu Thr Arg 
1               5                   10                  15      


Tyr Val Met Glu Lys Gly Arg Gln Ala Lys Gly Thr Gly Glu Leu Thr 
            20                  25                  30          


Gln Leu Leu Asn Ser Met Leu Thr Ala Ile Lys Ala Ile Ser Ser Ala 
        35                  40                  45              


Val Arg Lys Ala Gly Leu Ala His Leu Tyr Gly Ile Ala Gly Ser Val 
    50                  55                  60                  


Asn Val Thr Gly Asp Glu Val Lys Lys Leu Asp Val Leu Ser Asn Ser 
65                  70                  75                  80  


Leu Val Ile Asn Met Val Gln Ser Ser Tyr Ser Thr Cys Val Leu Val 
                85                  90                  95      


Ser Glu Glu Asn Lys Asp Ala Ile Ile Thr Ala Lys Glu Lys Arg Gly 
            100                 105                 110         


Lys Tyr Val Val Cys Phe Asp Pro Leu Asp Gly Ser Ser Asn Ile Asp 
        115                 120                 125             


Cys Leu Ala Ser Ile Gly Thr Ile Phe Ala Ile Tyr Arg Lys Thr Ser 
    130                 135                 140                 


Glu Asp Glu Pro Ser Glu Lys Asp Ala Leu Gln Cys Gly Arg Asn Ile 
145                 150                 155                 160 


Val Ala Ala Gly Tyr Ala Leu Tyr Gly Ser Ala Thr Leu Val Ala Leu 
                165                 170                 175     


Ser Thr Gly Gln Gly Val Asp Leu Phe Met Leu Asp Pro Ala Leu Gly 
            180                 185                 190         


Glu Phe Val Leu Val Glu Lys Asp Val Lys Ile Lys Lys Lys Gly Lys 
        195                 200                 205             


Ile Tyr Ser Leu Asn Glu Gly Tyr Ala Lys Tyr Phe Asp Ala Ala Thr 
    210                 215                 220                 


Thr Glu Tyr Val Gln Lys Lys Lys Phe Pro Glu Asp Gly Ser Ala Pro 
225                 230                 235                 240 


Tyr Gly Ala Arg Tyr Val Gly Ser Met Val Ala Asp Val His Arg Thr 
                245                 250                 255     


Leu Val Tyr Gly Gly Ile Phe Leu Tyr Pro Ala Asn Gln Lys Ser Pro 
            260                 265                 270         


Lys Gly Lys Leu Arg Leu Leu Tyr Glu Cys Asn Pro Val Ala Tyr Ile 
        275                 280                 285             


Ile Glu Gln Ala Gly Gly Leu Ala Thr Thr Gly Thr Gln Pro Val Leu 
    290                 295                 300                 


Asp Val Lys Pro Glu Ala Ile His Gln Arg Val Pro Leu Ile Leu Gly 
305                 310                 315                 320 


Ser Pro Glu Asp Val Gln Glu Tyr Leu Thr Cys Val Gln Lys Asn Gln 
                325                 330                 335     


Ala Gly Ser 
            


<210>  3921
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBRS__Homo_sapiens__NP_001098549

<400>  3921

Met Glu Thr Ala Ala Ala Ala Ala Pro Gly Pro Gly Trp Ala Ala Glu 
1               5                   10                  15      


Gly Glu Arg Arg Arg Arg Arg Cys Ser Arg Arg Asp Arg Asp Arg Glu 
            20                  25                  30          


Gln Arg Arg Arg Arg Gly Pro Gly Gly Asp Ala Pro Arg Ala Leu Leu 
        35                  40                  45              


Ala Ala Pro Arg Gly Ser Ser Ser Ser Ser Ser Pro Pro Pro Pro Ala 
    50                  55                  60                  


Arg Pro Trp Ser Ser Ala Ser Ser Gly Glu Arg Pro Gly Gly Pro Arg 
65                  70                  75                  80  


Arg Arg Arg Pro Arg Pro Arg Pro Arg Pro Pro Arg Pro Arg Ala Arg 
                85                  90                  95      


Lys Arg Pro Ala Gly Ser Gly Ser Arg Gly Glu Glu Glu Glu Glu Glu 
            100                 105                 110         


Glu Glu Glu Gly Gly Ala Asp Asp Gly Glu Ala Glu Glu Glu Pro Glu 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Asp Leu Ile Asp Gly Phe Ala Ile Ala 
    130                 135                 140                 


Ser Phe Ala Thr Leu Glu Ala Leu Gln Lys Asp Ala Ser Leu Gln Pro 
145                 150                 155                 160 


Pro Glu Arg Leu Glu His Arg Leu Lys His Ser Gly Lys Arg Lys Arg 
                165                 170                 175     


Gly Gly Ser Ser Gly Ala Thr Gly Glu Pro Gly Asp Ser Ser Asp Arg 
            180                 185                 190         


Glu Pro Gly Arg Pro Pro Gly Asp Arg Ala Arg Lys Trp Pro Asn Lys 
        195                 200                 205             


Arg Arg Arg Lys Glu Ala Ser Ser Arg His Ser Leu Glu Ala Gly Tyr 
    210                 215                 220                 


Ile Cys Asp Ala Glu Ser Asp Leu Asp Glu Arg Val Ser Asp Asp Asp 
225                 230                 235                 240 


Leu Asp Pro Ser Phe Thr Val Ser Thr Ser Lys Ala Ser Gly Pro His 
                245                 250                 255     


Gly Ala Phe Asn Gly Asn Cys Glu Ala Lys Leu Ser Val Val Pro Lys 
            260                 265                 270         


Val Ser Gly Leu Glu Arg Ser Gln Glu Gln Pro Pro Gly Pro Asp Pro 
        275                 280                 285             


Leu Leu Val Pro Phe Pro Pro Lys Glu Pro Pro Pro Pro Pro Val Pro 
    290                 295                 300                 


Arg Pro Pro Val Ser Pro Pro Ala Pro Leu Pro Ala Thr Pro Ser Leu 
305                 310                 315                 320 


Pro Pro Pro Pro Gln Pro Gln Leu Gln Leu Arg Val Ser Pro Phe Gly 
                325                 330                 335     


Leu Arg Thr Ser Pro Tyr Gly Ser Ser Leu Asp Leu Ser Thr Gly Ser 
            340                 345                 350         


Ser Ser Arg Pro Pro Pro Lys Ala Pro Ala Pro Pro Val Ala Gln Pro 
        355                 360                 365             


Pro Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser Ser 
    370                 375                 380                 


Ser Ser Ala Gln Leu Thr His Arg Pro Pro Thr Pro Ser Leu Pro Leu 
385                 390                 395                 400 


Pro Leu Ser Thr His Ser Phe Pro Pro Pro Gly Leu Arg Pro Pro Pro 
                405                 410                 415     


Pro Pro His His Pro Ser Leu Phe Ser Pro Gly Pro Thr Leu Pro Pro 
            420                 425                 430         


Pro Pro Pro Leu Leu Gln Val Pro Gly His Pro Gly Ala Ser Ala Ala 
        435                 440                 445             


Asn Ala Leu Ser Glu Gln Asp Leu Ile Gly Gln Asp Leu Asn Ser Arg 
    450                 455                 460                 


Tyr Leu Asn Ala Gln Gly Gly Pro Glu Val Val Gly Ala Gly Gly Ser 
465                 470                 475                 480 


Ala Arg Pro Leu Ala Phe Gln Phe His Gln His Asn His Gln His Gln 
                485                 490                 495     


His Thr His Gln His Thr His Gln His Phe Thr Pro Tyr Pro Pro Gly 
            500                 505                 510         


Leu Leu Pro Pro His Gly Pro His Met Phe Glu Lys Tyr Pro Gly Lys 
        515                 520                 525             


Met Glu Gly Leu Phe Arg His Asn Pro Tyr Thr Ala Phe Pro Pro Ala 
    530                 535                 540                 


Val Pro Gly Leu Pro Pro Gly Leu Pro Pro Ala Val Ser Phe Gly Ser 
545                 550                 555                 560 


Leu Gln Gly Ala Phe Gln Pro Lys Ser Thr Asn Pro Glu Leu Pro Pro 
                565                 570                 575     


Arg Leu Gly Pro Val Pro Ser Gly Leu Ser Gln Lys Gly Thr Gln Ile 
            580                 585                 590         


Pro Asp His Phe Arg Pro Pro Leu Arg Lys Pro Gly Lys Trp Cys Ala 
        595                 600                 605             


Met His Val Arg Val Ala Tyr Met Ile Leu Arg His Gln Glu Lys Met 
    610                 615                 620                 


Lys Gly Asp Ser His Lys Leu Asp Phe Arg Asn Asp Leu Leu Pro Cys 
625                 630                 635                 640 


Leu Pro Gly Pro Tyr Gly Ala Leu Pro Pro Gly Gln Glu Leu Ser His 
                645                 650                 655     


Pro Ala Ser Leu Phe Thr Ala Thr Gly Ala Val His Ala Ala Ala Asn 
            660                 665                 670         


Pro Phe Thr Ala Ala Pro Gly Ala His Gly Pro Phe Leu Ser Pro Ser 
        675                 680                 685             


Thr His Ile Asp Pro Phe Gly Arg Pro Thr Ser Phe Ala Ser Leu Ala 
    690                 695                 700                 


Ala Leu Ser Asn Gly Ala Phe Gly Gly Leu Gly Ser Pro Thr Phe Asn 
705                 710                 715                 720 


Ser Gly Ala Val Phe Ala Gln Lys Glu Ser Pro Gly Ala Pro Pro Ala 
                725                 730                 735     


Phe Ala Ser Pro Pro Asp Pro Trp Gly Arg Leu His Arg Ser Pro Leu 
            740                 745                 750         


Thr Phe Pro Ala Trp Val Arg Pro Pro Glu Ala Ala Arg Thr Pro Gly 
        755                 760                 765             


Ser Asp Lys Glu Arg Pro Val Glu Arg Arg Glu Pro Ser Ile Thr Lys 
    770                 775                 780                 


Glu Glu Lys Asp Arg Asp Leu Pro Phe Ser Arg Pro Gln Leu Arg Val 
785                 790                 795                 800 


Ser Pro Ala Thr Pro Lys Ala Arg Ala Gly Glu Glu Gly Pro Arg Pro 
                805                 810                 815     


Thr Lys Glu Ser Val Arg Val Lys Glu Glu Arg Lys Glu Glu Ala Ala 
            820                 825                 830         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        835                 840                 845             


Ala Thr Gly Pro Gln Gly Leu His Leu Leu Phe Glu Arg Pro Arg Pro 
    850                 855                 860                 


Pro Pro Phe Leu Gly Pro Ser Pro Pro Asp Arg Cys Ala Gly Phe Leu 
865                 870                 875                 880 


Glu Pro Thr Trp Leu Ala Ala Pro Pro Arg Leu Ala Arg Pro Pro Arg 
                885                 890                 895     


Phe Tyr Glu Ala Gly Glu Glu Leu Thr Gly Pro Gly Ala Val Ala Ala 
            900                 905                 910         


Ala Arg Leu Tyr Gly Leu Glu Pro Ala His Pro Leu Leu Tyr Ser Arg 
        915                 920                 925             


Leu Ala Pro Pro Pro Pro Pro Ala Ala Ala Pro Gly Thr Pro His Leu 
    930                 935                 940                 


Leu Ser Lys Thr Pro Pro Gly Ala Leu Leu Gly Ala Pro Pro Pro Leu 
945                 950                 955                 960 


Val Pro Ala Pro Arg Pro Ser Ser Pro Pro Arg Gly Pro Gly Pro Ala 
                965                 970                 975     


Arg Ala Asp Arg 
            980 


<210>  3922
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL15__Homo_sapiens__NP_077302

<400>  3922

Met Glu Pro Pro Met Glu Pro Ser Gly Gly Glu Gln Glu Pro Gly Ala 
1               5                   10                  15      


Val Arg Phe Leu Asp Leu Pro Trp Glu Asp Val Leu Leu Pro His Val 
            20                  25                  30          


Leu Asn Arg Val Pro Leu Arg Gln Leu Leu Arg Leu Gln Arg Val Ser 
        35                  40                  45              


Arg Ala Phe Arg Ser Leu Val Gln Leu His Leu Ala Gly Leu Arg Arg 
    50                  55                  60                  


Phe Asp Ala Ala Gln Val Gly Pro Gln Ile Pro Arg Ala Ala Leu Ala 
65                  70                  75                  80  


Arg Leu Leu Arg Asp Ala Glu Gly Leu Gln Glu Leu Ala Leu Ala Pro 
                85                  90                  95      


Cys His Glu Trp Leu Ser Asp Glu Asp Leu Val Pro Val Leu Ala Arg 
            100                 105                 110         


Asn Pro Gln Leu Arg Ser Val Ala Leu Gly Gly Cys Gly Gln Leu Ser 
        115                 120                 125             


Arg Arg Ala Leu Gly Ala Leu Ala Glu Gly Cys Pro Arg Leu Gln Arg 
    130                 135                 140                 


Leu Ser Leu Ala His Cys Asp Trp Val Asp Gly Leu Ala Leu Arg Gly 
145                 150                 155                 160 


Leu Ala Asp Arg Cys Pro Ala Leu Glu Glu Leu Asp Leu Thr Ala Cys 
                165                 170                 175     


Arg Gln Leu Lys Asp Glu Ala Ile Val Tyr Leu Ala Gln Arg Arg Gly 
            180                 185                 190         


Ala Gly Leu Arg Ser Leu Ser Leu Ala Val Asn Ala Asn Val Gly Asp 
        195                 200                 205             


Ala Ala Val Gln Glu Leu Ala Arg Asn Cys Pro Glu Leu His His Leu 
    210                 215                 220                 


Asp Leu Thr Gly Cys Leu Arg Val Gly Ser Asp Gly Val Arg Thr Leu 
225                 230                 235                 240 


Ala Glu Tyr Cys Pro Val Leu Arg Ser Leu Arg Val Arg His Cys His 
                245                 250                 255     


His Val Ala Glu Ser Ser Leu Ser Arg Leu Arg Lys Arg Gly Val Asp 
            260                 265                 270         


Ile Asp Val Glu Pro Pro Leu His Gln Ala Leu Val Leu Leu Gln Asp 
        275                 280                 285             


Met Ala Gly Phe Ala Pro Phe Val Asn Leu Gln Val 
    290                 295                 300 


<210>  3923
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL17__Homo_sapiens__NP_001156787

<400>  3923

Met Gly His Leu Leu Ser Lys Glu Pro Arg Asn Arg Pro Ser Gln Lys 
1               5                   10                  15      


Arg Pro Arg Cys Cys Ser Trp Cys Arg Arg Arg Arg Pro Leu Leu Arg 
            20                  25                  30          


Leu Pro Arg Arg Thr Pro Ala Lys Val Pro Pro Gln Pro Ala Ala Pro 
        35                  40                  45              


Arg Ser Arg Asp Cys Phe Phe Arg Gly Pro Cys Met Leu Cys Phe Ile 
    50                  55                  60                  


Val His Ser Pro Gly Ala Pro Ala Pro Ala Gly Pro Glu Glu Glu Pro 
65                  70                  75                  80  


Pro Leu Ser Pro Pro Pro Arg Asp Gly Ala Tyr Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Gln His Leu Ala Arg Arg Tyr Ala Ala Leu Ala Ala Glu Asp Cys 
            100                 105                 110         


Ala Ala Ala Ala Arg Arg Phe Leu Leu Ser Ser Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ser Ala Ser Ser Pro Ala Ser Cys Cys Lys Glu Leu 
    130                 135                 140                 


Gly Leu Ala Ala Ala Ala Ala Trp Glu Gln Gln Gly Arg Ser Leu Phe 
145                 150                 155                 160 


Leu Ala Ser Leu Gly Pro Val Arg Phe Leu Gly Pro Pro Ala Ala Val 
                165                 170                 175     


Gln Leu Phe Arg Gly Pro Thr Pro Ser Pro Ala Glu Leu Pro Thr Pro 
            180                 185                 190         


Pro Glu Met Val Cys Lys Arg Lys Gly Ala Gly Val Pro Ala Cys Thr 
        195                 200                 205             


Pro Cys Lys Gln Pro Arg Cys Gly Gly Gly Gly Cys Gly Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Pro Ala Gly Gly Gly Ala Ser Pro Pro 
225                 230                 235                 240 


Arg Pro Pro Asp Ala Gly Cys Cys Gln Ala Pro Glu Gln Pro Pro Gln 
                245                 250                 255     


Pro Leu Cys Pro Pro Pro Ser Ser Pro Thr Ser Glu Gly Ala Pro Thr 
            260                 265                 270         


Glu Ala Gly Gly Asp Ala Val Arg Ala Gly Gly Thr Ala Pro Leu Ser 
        275                 280                 285             


Ala Gln Gln Gln His Glu Cys Gly Asp Ala Asp Cys Arg Glu Ser Pro 
    290                 295                 300                 


Glu Asn Pro Cys Asp Cys His Arg Glu Pro Pro Pro Glu Thr Pro Asp 
305                 310                 315                 320 


Ile Asn Gln Leu Pro Pro Ser Ile Leu Leu Lys Ile Phe Ser Asn Leu 
                325                 330                 335     


Ser Leu Asp Glu Arg Cys Leu Ser Ala Ser Leu Val Cys Lys Tyr Trp 
            340                 345                 350         


Arg Asp Leu Cys Leu Asp Phe Gln Phe Trp Lys Gln Leu Asp Leu Ser 
        355                 360                 365             


Ser Arg Gln Gln Val Thr Asp Glu Leu Leu Glu Lys Ile Ala Ser Arg 
    370                 375                 380                 


Ser Gln Asn Ile Ile Glu Ile Asn Ile Ser Asp Cys Arg Ser Met Ser 
385                 390                 395                 400 


Asp Asn Gly Val Cys Val Leu Ala Phe Lys Cys Pro Gly Leu Leu Arg 
                405                 410                 415     


Tyr Thr Ala Tyr Arg Cys Lys Gln Leu Ser Asp Thr Ser Ile Ile Ala 
            420                 425                 430         


Val Ala Ser His Cys Pro Leu Leu Gln Lys Val His Val Gly Asn Gln 
        435                 440                 445             


Asp Lys Leu Thr Asp Glu Gly Leu Lys Gln Leu Gly Ser Lys Cys Arg 
    450                 455                 460                 


Glu Leu Lys Asp Ile His Phe Gly Gln Cys Tyr Lys Ile Ser Asp Glu 
465                 470                 475                 480 


Gly Met Ile Val Ile Ala Lys Gly Cys Leu Lys Leu Gln Arg Ile Tyr 
                485                 490                 495     


Met Gln Glu Asn Lys Leu Val Thr Asp Gln Ser Val Lys Ala Phe Ala 
            500                 505                 510         


Glu His Cys Pro Glu Leu Gln Tyr Val Gly Phe Met Gly Cys Ser Val 
        515                 520                 525             


Thr Ser Lys Gly Val Ile His Leu Thr Lys Leu Arg Asn Leu Ser Ser 
    530                 535                 540                 


Leu Asp Leu Arg His Ile Thr Glu Leu Asp Asn Glu Thr Val Met Glu 
545                 550                 555                 560 


Ile Val Lys Arg Cys Lys Asn Leu Ser Ser Leu Asn Leu Cys Leu Asn 
                565                 570                 575     


Trp Ile Ile Asn Asp Arg Cys Val Glu Val Ile Ala Lys Glu Gly Gln 
            580                 585                 590         


Asn Leu Lys Glu Leu Tyr Leu Val Ser Cys Lys Ile Thr Asp Tyr Ala 
        595                 600                 605             


Leu Ile Ala Ile Gly Arg Tyr Ser Met Thr Ile Glu Thr Val Asp Val 
    610                 615                 620                 


Gly Trp Cys Lys Glu Ile Thr Asp Gln Gly Ala Thr Leu Ile Ala Gln 
625                 630                 635                 640 


Ser Ser Lys Ser Leu Arg Tyr Leu Gly Leu Met Arg Cys Asp Lys Val 
                645                 650                 655     


Asn Glu Val Thr Val Glu Gln Leu Val Gln Gln Tyr Pro His Ile Thr 
            660                 665                 670         


Phe Ser Thr Val Leu Gln Asp Cys Lys Arg Thr Leu Glu Arg Ala Tyr 
        675                 680                 685             


Gln Met Gly Trp Thr Pro Asn Met Ser Ala Ala Ser Ser 
    690                 695                 700     


<210>  3924
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL19__Homo_sapiens__NP_001093254

<400>  3924

Met Gly Met Lys Val Pro Gly Lys Gly Glu Ser Gly Pro Ser Ala Leu 
1               5                   10                  15      


Leu Thr Pro Pro Met Ser Ser Ser Ser Arg Gly Pro Gly Ala Gly Ala 
            20                  25                  30          


Arg Arg Arg Arg Thr Arg Cys Arg Arg Cys Arg Ala Cys Val Arg Thr 
        35                  40                  45              


Glu Cys Gly Asp Cys His Phe Cys Arg Asp Met Lys Lys Phe Gly Gly 
    50                  55                  60                  


Pro Gly Arg Met Lys Gln Ser Cys Leu Leu Arg Gln Cys Thr Ala Pro 
65                  70                  75                  80  


Val Leu Pro His Thr Ala Val Cys Leu Leu Cys Gly Glu Ala Gly Lys 
                85                  90                  95      


Glu Asp Thr Val Glu Gly Glu Glu Glu Lys Phe Gly Leu Ser Leu Met 
            100                 105                 110         


Glu Cys Thr Ile Cys Asn Glu Ile Val His Pro Gly Cys Leu Lys Met 
        115                 120                 125             


Gly Lys Ala Glu Gly Val Ile Asn Ala Glu Ile Pro Asn Cys Trp Glu 
    130                 135                 140                 


Cys Pro Arg Cys Thr Gln Glu Gly Arg Thr Ser Lys Asp Ser Gly Glu 
145                 150                 155                 160 


Gly Pro Gly Arg Arg Arg Ala Asp Asn Gly Glu Glu Gly Ala Ser Leu 
                165                 170                 175     


Gly Ser Gly Trp Lys Leu Thr Glu Glu Pro Pro Leu Pro Pro Pro Pro 
            180                 185                 190         


Pro Arg Arg Lys Gly Pro Leu Pro Ala Gly Pro Pro Pro Glu Asp Val 
        195                 200                 205             


Pro Gly Pro Pro Lys Arg Lys Glu Arg Glu Ala Gly Asn Glu Pro Pro 
    210                 215                 220                 


Thr Pro Arg Lys Lys Val Lys Gly Gly Arg Glu Arg His Leu Lys Lys 
225                 230                 235                 240 


Val Gly Gly Asp Ala Cys Leu Leu Arg Gly Ser Asp Pro Gly Gly Pro 
                245                 250                 255     


Gly Leu Leu Pro Pro Arg Val Leu Asn Pro Ser Gln Ala Phe Ser Ser 
            260                 265                 270         


Cys His Pro Gly Leu Pro Pro Glu Asn Trp Glu Lys Pro Lys Pro Pro 
        275                 280                 285             


Leu Ala Ser Ala Glu Gly Pro Ala Val Pro Ser Pro Ser Pro Gln Arg 
    290                 295                 300                 


Glu Lys Leu Glu Arg Phe Lys Arg Met Cys Gln Leu Leu Glu Arg Val 
305                 310                 315                 320 


Pro Asp Thr Ser Ser Ser Ser Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                325                 330                 335     


Ser Gly Thr Ser Leu Ser Glu Asp Glu Ala Pro Gly Glu Ala Arg Asn 
            340                 345                 350         


Gly Arg Arg Pro Ala Arg Gly Ser Ser Gly Glu Lys Glu Asn Arg Gly 
        355                 360                 365             


Gly Arg Arg Ala Val Arg Pro Gly Ser Gly Gly Pro Leu Leu Ser Trp 
    370                 375                 380                 


Pro Leu Gly Pro Ala Pro Pro Pro Arg Pro Pro Gln Leu Glu Arg His 
385                 390                 395                 400 


Val Val Arg Pro Pro Pro Arg Ser Pro Glu Pro Asp Thr Leu Pro Leu 
                405                 410                 415     


Ala Ala Gly Ser Asp His Pro Leu Pro Arg Ala Ala Trp Leu Arg Val 
            420                 425                 430         


Phe Gln His Leu Gly Pro Arg Glu Leu Cys Ile Cys Met Arg Val Cys 
        435                 440                 445             


Arg Thr Trp Ser Arg Trp Cys Tyr Asp Lys Arg Leu Trp Pro Arg Met 
    450                 455                 460                 


Asp Leu Ser Arg Arg Lys Ser Leu Thr Pro Pro Met Leu Ser Gly Val 
465                 470                 475                 480 


Val Arg Arg Gln Pro Arg Ala Leu Asp Leu Ser Trp Thr Gly Val Ser 
                485                 490                 495     


Lys Lys Gln Leu Met Trp Leu Leu Asn Arg Leu Gln Gly Leu Gln Glu 
            500                 505                 510         


Leu Val Leu Ser Gly Cys Ser Trp Leu Ser Val Ser Ala Leu Gly Ser 
        515                 520                 525             


Ala Pro Leu Pro Ala Leu Arg Leu Leu Asp Leu Arg Trp Ile Glu Asp 
    530                 535                 540                 


Val Lys Asp Ser Gln Leu Arg Glu Leu Leu Leu Pro Pro Pro Asp Thr 
545                 550                 555                 560 


Lys Pro Gly Gln Thr Glu Ser Arg Gly Arg Leu Gln Gly Val Ala Glu 
                565                 570                 575     


Leu Arg Leu Ala Gly Leu Glu Leu Thr Asp Ala Ser Leu Arg Leu Leu 
            580                 585                 590         


Leu Arg His Ala Pro Gln Leu Ser Ala Leu Asp Leu Ser His Cys Ala 
        595                 600                 605             


His Val Gly Asp Pro Ser Val His Leu Leu Thr Ala Pro Thr Ser Pro 
    610                 615                 620                 


Leu Arg Glu Thr Leu Val His Leu Asn Leu Ala Gly Cys His Arg Leu 
625                 630                 635                 640 


Thr Asp His Cys Leu Pro Leu Phe Arg Arg Cys Pro Arg Leu Arg Arg 
                645                 650                 655     


Leu Asp Leu Arg Ser Cys Arg Gln Leu Ser Pro Glu Ala Cys Ala Arg 
            660                 665                 670         


Leu Ala Ala Ala Gly Pro Pro Gly Pro Phe Arg Cys Pro Glu Glu Lys 
        675                 680                 685             


Leu Leu Leu Lys Asp Ser 
    690                 


<210>  3925
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL20__Homo_sapiens__NP_001171835

<400>  3925

Met Arg Arg Asp Val Asn Gly Val Thr Lys Ser Arg Phe Glu Met Phe 
1               5                   10                  15      


Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro Lys Glu Leu 
            20                  25                  30          


Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu Cys Arg Cys 
        35                  40                  45              


Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile Glu Gly Arg 
65                  70                  75                  80  


Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu Arg Lys Leu 
                85                  90                  95      


Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu Arg Thr Phe 
            100                 105                 110         


Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn Gly Cys Thr 
        115                 120                 125             


Lys Thr Thr Asp Ala Glu Gly Cys Pro Leu Leu Glu Gln Leu Asn Ile 
    130                 135                 140                 


Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala Leu Val Arg 
145                 150                 155                 160 


Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys Thr Gln Leu 
                165                 170                 175     


Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro Glu Leu Val 
            180                 185                 190         


Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu Gly Leu Ile 
        195                 200                 205             


Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys Ala Ser Gly 
    210                 215                 220                 


Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly Gln Asn Cys 
225                 230                 235                 240 


Pro Arg Leu Arg Ile Leu Glu Val Ala Arg Cys Ser Gln Leu Thr Asp 
                245                 250                 255     


Val Gly Phe Thr Thr Leu Ala Arg Asn Cys His Glu Leu Glu Lys Met 
            260                 265                 270         


Asp Leu Glu Glu Cys Val Gln Ile Thr Asp Ser Thr Leu Ile Gln Leu 
        275                 280                 285             


Ser Ile His Cys Pro Arg Leu Gln Val Leu Ser Leu Ser His Cys Glu 
    290                 295                 300                 


Leu Ile Thr Asp Asp Gly Ile Arg His Leu Gly Asn Gly Ala Cys Ala 
305                 310                 315                 320 


His Asp Gln Leu Glu Val Ile Glu Leu Asp Asn Cys Pro Leu Ile Thr 
                325                 330                 335     


Asp Ala Ser Leu Glu His Leu Lys Ser Cys His Ser Leu Glu Arg Ile 
            340                 345                 350         


Glu Leu Tyr Asp Cys Gln Gln Ile Thr Arg Ala Gly Ile Lys Arg Leu 
        355                 360                 365             


Arg Thr His Leu Pro Asn Ile Lys Val His Ala Tyr Phe Ala Pro Val 
    370                 375                 380                 


Thr Pro Pro Pro Ser Val Gly Gly Ser Arg Gln Arg Phe Cys Arg Cys 
385                 390                 395                 400 


Cys Ile Ile Leu 
                


<210>  3926
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL2__Homo_sapiens__NP_001165184

<400>  3926

Met Val Phe Ser Asn Asn Asp Glu Gly Leu Ile Asn Lys Lys Leu Pro 
1               5                   10                  15      


Lys Glu Leu Leu Leu Arg Ile Phe Ser Phe Leu Asp Ile Val Thr Leu 
            20                  25                  30          


Cys Arg Cys Ala Gln Ile Ser Lys Ala Trp Asn Ile Leu Ala Leu Asp 
        35                  40                  45              


Gly Ser Asn Trp Gln Arg Ile Asp Leu Phe Asn Phe Gln Thr Asp Val 
    50                  55                  60                  


Glu Gly Arg Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu 
65                  70                  75                  80  


Arg Lys Leu Ser Leu Arg Gly Cys Ile Gly Val Gly Asp Ser Ser Leu 
                85                  90                  95      


Lys Thr Phe Ala Gln Asn Cys Arg Asn Ile Glu His Leu Asn Leu Asn 
            100                 105                 110         


Gly Cys Thr Lys Ile Thr Asp Ser Thr Cys Tyr Ser Leu Ser Arg Phe 
        115                 120                 125             


Cys Ser Lys Leu Lys His Ile Gln Asn Tyr Cys His Glu Leu Val Ser 
    130                 135                 140                 


Leu Asn Leu Gln Ser Cys Ser Arg Ile Thr Asp Glu Gly Val Val Gln 
145                 150                 155                 160 


Ile Cys Arg Gly Cys His Arg Leu Gln Ala Leu Cys Leu Ser Gly Cys 
                165                 170                 175     


Ser Asn Leu Thr Asp Ala Ser Leu Thr Ala Leu Gly Leu Asn Cys Pro 
            180                 185                 190         


Arg Leu Gln Ile Leu Glu Ala Ala Arg Cys Ser His Leu Thr Asp Ala 
        195                 200                 205             


Gly Phe Thr Leu Leu Ala Arg Asn Cys His Glu Leu Glu Lys Met Asp 
    210                 215                 220                 


Leu Glu Glu Cys Ile Leu Ile Thr Asp Ser Thr Leu Ile Gln Leu Ser 
225                 230                 235                 240 


Ile His Cys Pro Lys Leu Gln Ala Leu Ser Leu Ser His Cys Glu Leu 
                245                 250                 255     


Ile Thr Asp Asp Gly Ile Leu His Leu Ser Asn Ser Thr Cys Gly His 
            260                 265                 270         


Glu Arg Leu Arg Val Leu Glu Leu Asp Asn Cys Leu Leu Ile Thr Asp 
        275                 280                 285             


Val Ala Leu Glu His Leu Glu Asn Cys Arg Gly Leu Glu Arg Leu Glu 
    290                 295                 300                 


Leu Tyr Asp Cys Gln Gln Val Thr Arg Ala Gly Ile Lys Arg Met Arg 
305                 310                 315                 320 


Ala Gln Leu Pro His Val Lys Val His Ala Tyr Phe Ala Pro Val Thr 
                325                 330                 335     


Pro Pro Thr Ala Val Ala Gly Ser Gly Gln Arg Leu Cys Arg Cys Cys 
            340                 345                 350         


Val Ile Leu 
        355 


<210>  3927
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL3__Homo_sapiens__NP_036290

<400>  3927

Met Lys Arg Gly Gly Arg Asp Ser Asp Arg Asn Ser Ser Glu Glu Gly 
1               5                   10                  15      


Thr Ala Glu Lys Ser Lys Lys Leu Arg Thr Thr Asn Glu His Ser Gln 
            20                  25                  30          


Thr Cys Asp Trp Gly Asn Leu Leu Gln Asp Ile Ile Leu Gln Val Phe 
        35                  40                  45              


Lys Tyr Leu Pro Leu Leu Asp Arg Ala His Ala Ser Gln Val Cys Arg 
    50                  55                  60                  


Asn Trp Asn Gln Val Phe His Met Pro Asp Leu Trp Arg Cys Phe Glu 
65                  70                  75                  80  


Phe Glu Leu Asn Gln Pro Ala Thr Ser Tyr Leu Lys Ala Thr His Pro 
                85                  90                  95      


Glu Leu Ile Lys Gln Ile Ile Lys Arg His Ser Asn His Leu Gln Tyr 
            100                 105                 110         


Val Ser Phe Lys Val Asp Ser Ser Lys Glu Ser Ala Glu Ala Ala Cys 
        115                 120                 125             


Asp Ile Leu Ser Gln Leu Val Asn Cys Ser Leu Lys Thr Leu Gly Leu 
    130                 135                 140                 


Ile Ser Thr Ala Arg Pro Ser Phe Met Asp Leu Pro Lys Ser His Phe 
145                 150                 155                 160 


Ile Ser Ala Leu Thr Val Val Phe Val Asn Ser Lys Ser Leu Ser Ser 
                165                 170                 175     


Leu Lys Ile Asp Asp Thr Pro Val Asp Asp Pro Ser Leu Lys Val Leu 
            180                 185                 190         


Val Ala Asn Asn Ser Asp Thr Leu Lys Leu Leu Lys Met Ser Ser Cys 
        195                 200                 205             


Pro His Val Ser Pro Ala Gly Ile Leu Cys Val Ala Asp Gln Cys His 
    210                 215                 220                 


Gly Leu Arg Glu Leu Ala Leu Asn Tyr His Leu Leu Ser Asp Glu Leu 
225                 230                 235                 240 


Leu Leu Ala Leu Ser Ser Glu Lys His Val Arg Leu Glu His Leu Arg 
                245                 250                 255     


Ile Asp Val Val Ser Glu Asn Pro Gly Gln Thr His Phe His Thr Ile 
            260                 265                 270         


Gln Lys Ser Ser Trp Asp Ala Phe Ile Arg His Ser Pro Lys Val Asn 
        275                 280                 285             


Leu Val Met Tyr Phe Phe Leu Tyr Glu Glu Glu Phe Asp Pro Phe Phe 
    290                 295                 300                 


Arg Tyr Glu Ile Pro Ala Thr His Leu Tyr Phe Gly Arg Ser Val Ser 
305                 310                 315                 320 


Lys Asp Val Leu Gly Arg Val Gly Met Thr Cys Pro Arg Leu Val Glu 
                325                 330                 335     


Leu Val Val Cys Ala Asn Gly Leu Arg Pro Leu Asp Glu Glu Leu Ile 
            340                 345                 350         


Arg Ile Ala Glu Arg Cys Lys Asn Leu Ser Ala Ile Gly Leu Gly Glu 
        355                 360                 365             


Cys Glu Val Ser Cys Ser Ala Phe Val Glu Phe Val Lys Met Cys Gly 
    370                 375                 380                 


Gly Arg Leu Ser Gln Leu Ser Ile Met Glu Glu Val Leu Ile Pro Asp 
385                 390                 395                 400 


Gln Lys Tyr Ser Leu Glu Gln Ile His Trp Glu Val Ser Lys His Leu 
                405                 410                 415     


Gly Arg Val Trp Phe Pro Asp Met Met Pro Thr Trp 
            420                 425             


<210>  3928
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL4__Homo_sapiens__NP_001265645

<400>  3928

Met Ser Pro Val Phe Pro Met Leu Thr Val Leu Thr Met Phe Tyr Tyr 
1               5                   10                  15      


Ile Cys Leu Arg Arg Arg Ala Arg Thr Ala Thr Arg Gly Glu Met Met 
            20                  25                  30          


Asn Thr His Arg Ala Ile Glu Ser Asn Ser Gln Thr Ser Pro Leu Asn 
        35                  40                  45              


Ala Glu Val Val Gln Tyr Ala Lys Glu Val Val Asp Phe Ser Ser His 
    50                  55                  60                  


Tyr Gly Ser Glu Asn Ser Met Ser Tyr Thr Met Trp Asn Leu Ala Gly 
65                  70                  75                  80  


Val Pro Asn Val Phe Pro Ser Ser Gly Asp Phe Thr Gln Thr Ala Val 
                85                  90                  95      


Phe Arg Thr Tyr Gly Thr Trp Trp Asp Gln Cys Pro Ser Ala Ser Leu 
            100                 105                 110         


Pro Phe Lys Arg Thr Pro Pro Asn Phe Gln Ser Gln Asp Tyr Val Glu 
        115                 120                 125             


Leu Thr Phe Glu Gln Gln Val Tyr Pro Thr Ala Val His Val Leu Glu 
    130                 135                 140                 


Thr Tyr His Pro Gly Ala Val Ile Arg Ile Leu Ala Cys Ser Ala Asn 
145                 150                 155                 160 


Pro Tyr Ser Pro Asn Pro Pro Ala Glu Val Arg Trp Glu Ile Leu Trp 
                165                 170                 175     


Ser Glu Arg Pro Thr Lys Val Asn Ala Ser Gln Ala Arg Gln Phe Lys 
            180                 185                 190         


Pro Cys Ile Lys Gln Ile Asn Phe Pro Thr Asn Leu Ile Arg Leu Glu 
        195                 200                 205             


Val Asn Ser Ser Leu Leu Glu Tyr Tyr Thr Glu Leu Asp Ala Val Val 
    210                 215                 220                 


Leu His Gly Val Lys Asp Lys Pro Val Leu Ser Leu Lys Thr Ser Leu 
225                 230                 235                 240 


Ile Asp Met Asn Asp Ile Glu Asp Asp Ala Tyr Ala Glu Lys Asp Gly 
                245                 250                 255     


Cys Gly Met Asp Ser Leu Asn Lys Lys Phe Ser Ser Ala Val Leu Gly 
            260                 265                 270         


Glu Gly Pro Asn Asn Gly Tyr Phe Asp Lys Leu Pro Tyr Glu Leu Ile 
        275                 280                 285             


Gln Leu Ile Leu Asn His Leu Thr Leu Pro Asp Leu Cys Arg Leu Ala 
    290                 295                 300                 


Gln Thr Cys Lys Leu Leu Ser Gln His Cys Cys Asp Pro Leu Gln Tyr 
305                 310                 315                 320 


Ile His Leu Asn Leu Gln Pro Tyr Trp Ala Lys Leu Asp Asp Thr Ser 
                325                 330                 335     


Leu Glu Phe Leu Gln Ser Arg Cys Thr Leu Val Gln Trp Leu Asn Leu 
            340                 345                 350         


Ser Trp Thr Gly Asn Arg Gly Phe Ile Ser Val Ala Gly Phe Ser Arg 
        355                 360                 365             


Phe Leu Lys Val Cys Gly Ser Glu Leu Val Arg Leu Glu Leu Ser Cys 
    370                 375                 380                 


Ser His Phe Leu Asn Glu Thr Cys Leu Glu Val Ile Ser Glu Met Cys 
385                 390                 395                 400 


Pro Asn Leu Gln Ala Leu Asn Leu Ser Ser Cys Asp Lys Leu Pro Pro 
                405                 410                 415     


Gln Ala Phe Asn His Ile Ala Lys Leu Cys Ser Leu Lys Arg Leu Val 
            420                 425                 430         


Leu Tyr Arg Thr Lys Val Glu Gln Thr Ala Leu Leu Ser Ile Leu Asn 
        435                 440                 445             


Phe Cys Ser Glu Leu Gln His Leu Ser Leu Gly Ser Cys Val Met Ile 
    450                 455                 460                 


Glu Asp Tyr Asp Val Ile Ala Ser Met Ile Gly Ala Lys Cys Lys Lys 
465                 470                 475                 480 


Leu Arg Thr Leu Asp Leu Trp Arg Cys Lys Asn Ile Thr Glu Asn Gly 
                485                 490                 495     


Ile Ala Glu Leu Ala Ser Gly Cys Pro Leu Leu Glu Glu Leu Asp Leu 
            500                 505                 510         


Gly Trp Cys Pro Thr Leu Gln Ser Ser Thr Gly Cys Phe Thr Arg Leu 
        515                 520                 525             


Ala His Gln Leu Pro Asn Leu Gln Lys Leu Phe Leu Thr Ala Asn Arg 
    530                 535                 540                 


Ser Val Cys Asp Thr Asp Ile Asp Glu Leu Ala Cys Asn Cys Thr Arg 
545                 550                 555                 560 


Leu Gln Gln Leu Asp Ile Leu Gly Thr Arg Met Val Ser Pro Ala Ser 
                565                 570                 575     


Leu Arg Lys Leu Leu Glu Ser Cys Lys Asp Leu Ser Leu Leu Asp Val 
            580                 585                 590         


Ser Phe Cys Ser Gln Ile Asp Asn Arg Ala Val Leu Glu Leu Asn Ala 
        595                 600                 605             


Ser Phe Pro Lys Val Phe Ile Lys Lys Ser Phe Thr Gln 
    610                 615                 620     


<210>  3929
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL5__Homo_sapiens__NP_001180464

<400>  3929

Met Ala Pro Phe Pro Glu Glu Val Asp Val Phe Thr Ala Pro His Trp 
1               5                   10                  15      


Arg Met Lys Gln Leu Val Gly Leu Tyr Cys Asp Lys Ser Leu Tyr Ala 
            20                  25                  30          


Thr Phe Lys Glu Phe Lys Met His Glu Gln Ile Glu Asn Glu Tyr Ile 
        35                  40                  45              


Ile Gly Leu Leu Gln Gln Arg Ser Gln Thr Ile Tyr Asn Val His Ser 
    50                  55                  60                  


Asp Asn Lys Leu Ser Glu Met Leu Ser Leu Phe Glu Lys Gly Leu Lys 
65                  70                  75                  80  


Asn Val Lys Asn Glu Tyr Glu Gln Leu Asn Tyr Ala Lys Gln Leu Lys 
                85                  90                  95      


Glu Arg Leu Glu Ala Phe Thr Arg Asp Phe Leu Pro His Met Lys Glu 
            100                 105                 110         


Glu Glu Glu Val Phe Gln Pro Met Leu Met Glu Tyr Phe Thr Tyr Glu 
        115                 120                 125             


Glu Leu Lys Asp Ile Lys Lys Lys Val Ile Ala Gln His Cys Ser Gln 
    130                 135                 140                 


Lys Asp Thr Ala Glu Leu Leu Arg Gly Leu Ser Leu Trp Asn His Ala 
145                 150                 155                 160 


Glu Glu Arg Gln Lys Phe Phe Lys Tyr Ser Val Asp Glu Lys Ser Asp 
                165                 170                 175     


Lys Glu Ala Glu Val Ser Glu His Ser Thr Gly Ile Thr His Leu Pro 
            180                 185                 190         


Pro Glu Val Met Leu Ser Ile Phe Ser Tyr Leu Asn Pro Gln Glu Leu 
        195                 200                 205             


Cys Arg Cys Ser Gln Val Ser Met Lys Trp Ser Gln Leu Thr Lys Thr 
    210                 215                 220                 


Gly Ser Leu Trp Lys His Leu Tyr Pro Val His Trp Ala Arg Gly Asp 
225                 230                 235                 240 


Trp Tyr Ser Gly Pro Ala Thr Glu Leu Asp Thr Glu Pro Asp Asp Glu 
                245                 250                 255     


Trp Val Lys Asn Arg Lys Asp Glu Ser Arg Ala Phe His Glu Trp Asp 
            260                 265                 270         


Glu Asp Ala Asp Ile Asp Glu Ser Glu Glu Ser Ala Glu Glu Ser Ile 
        275                 280                 285             


Ala Ile Ser Ile Ala Gln Met Glu Lys Arg Leu Leu His Gly Leu Ile 
    290                 295                 300                 


His Asn Val Leu Pro Tyr Val Gly Thr Ser Val Lys Thr Leu Val Leu 
305                 310                 315                 320 


Ala Tyr Ser Ser Ala Val Ser Ser Lys Met Val Arg Gln Ile Leu Glu 
                325                 330                 335     


Leu Cys Pro Asn Leu Glu His Leu Asp Leu Thr Gln Thr Asp Ile Ser 
            340                 345                 350         


Asp Ser Ala Phe Asp Ser Trp Ser Trp Leu Gly Cys Cys Gln Ser Leu 
        355                 360                 365             


Arg His Leu Asp Leu Ser Gly Cys Glu Lys Ile Thr Asp Val Ala Leu 
    370                 375                 380                 


Glu Lys Ile Ser Arg Ala Leu Gly Ile Leu Thr Ser His Gln Ser Gly 
385                 390                 395                 400 


Phe Leu Lys Thr Ser Thr Ser Lys Ile Thr Ser Thr Ala Trp Lys Asn 
                405                 410                 415     


Lys Asp Ile Thr Met Gln Ser Thr Lys Gln Tyr Ala Cys Leu His Asp 
            420                 425                 430         


Leu Thr Asn Lys Gly Ile Gly Glu Glu Ile Asp Asn Glu His Pro Trp 
        435                 440                 445             


Thr Lys Pro Val Ser Ser Glu Asn Phe Thr Ser Pro Tyr Val Trp Met 
    450                 455                 460                 


Leu Asp Ala Glu Asp Leu Ala Asp Ile Glu Asp Thr Val Glu Trp Arg 
465                 470                 475                 480 


His Arg Asn Val Glu Ser Leu Cys Val Met Glu Thr Ala Ser Asn Phe 
                485                 490                 495     


Ser Cys Ser Thr Ser Gly Cys Phe Ser Lys Asp Ile Val Gly Leu Arg 
            500                 505                 510         


Thr Ser Val Cys Trp Gln Gln His Cys Ala Ser Pro Ala Phe Ala Tyr 
        515                 520                 525             


Cys Gly His Ser Phe Cys Cys Thr Gly Thr Ala Leu Arg Thr Met Ser 
    530                 535                 540                 


Ser Leu Pro Glu Ser Ser Ala Met Cys Arg Lys Ala Ala Arg Thr Arg 
545                 550                 555                 560 


Leu Pro Arg Gly Lys Asp Leu Ile Tyr Phe Gly Ser Glu Lys Ser Asp 
                565                 570                 575     


Gln Glu Thr Gly Arg Val Leu Leu Phe Leu Ser Leu Ser Gly Cys Tyr 
            580                 585                 590         


Gln Ile Thr Asp His Gly Leu Arg Val Leu Thr Leu Gly Gly Gly Leu 
        595                 600                 605             


Pro Tyr Leu Glu His Leu Asn Leu Ser Gly Cys Leu Thr Ile Thr Gly 
    610                 615                 620                 


Ala Gly Leu Gln Asp Leu Val Ser Ala Cys Pro Ser Leu Asn Asp Glu 
625                 630                 635                 640 


Tyr Phe Tyr Tyr Cys Asp Asn Ile Asn Gly Pro His Ala Asp Thr Ala 
                645                 650                 655     


Ser Gly Cys Gln Asn Leu Gln Cys Gly Phe Arg Ala Cys Cys Arg Ser 
            660                 665                 670         


Gly Glu 
        


<210>  3930
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXL7__Homo_sapiens__NP_036436

<400>  3930

Met Gly Ala Asn Asn Gly Lys Gln Tyr Gly Ser Glu Gly Lys Gly Ser 
1               5                   10                  15      


Ser Ser Ile Ser Ser Asp Val Ser Ser Ser Thr Asp His Thr Pro Thr 
            20                  25                  30          


Lys Ala Gln Lys Asn Val Ala Thr Ser Glu Asp Ser Asp Leu Ser Met 
        35                  40                  45              


Arg Thr Leu Ser Thr Pro Ser Pro Ala Leu Ile Cys Pro Pro Asn Leu 
    50                  55                  60                  


Pro Gly Phe Gln Asn Gly Arg Gly Ser Ser Thr Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Thr Gly Glu Thr Val Ala Met Val His Ser Pro Pro Pro Thr Arg Leu 
                85                  90                  95      


Thr His Pro Leu Ile Arg Leu Ala Ser Arg Pro Gln Lys Glu Gln Ala 
            100                 105                 110         


Ser Ile Asp Arg Leu Pro Asp His Ser Met Val Gln Ile Phe Ser Phe 
        115                 120                 125             


Leu Pro Thr Asn Gln Leu Cys Arg Cys Ala Arg Val Cys Arg Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Ala Trp Asp Pro Arg Leu Trp Arg Thr Ile Arg Leu Thr 
145                 150                 155                 160 


Gly Glu Thr Ile Asn Val Asp Arg Ala Leu Lys Val Leu Thr Arg Arg 
                165                 170                 175     


Leu Cys Gln Asp Thr Pro Asn Val Cys Leu Met Leu Glu Thr Val Thr 
            180                 185                 190         


Val Ser Gly Cys Arg Arg Leu Thr Asp Arg Gly Leu Tyr Thr Ile Ala 
        195                 200                 205             


Gln Cys Cys Pro Glu Leu Arg Arg Leu Glu Val Ser Gly Cys Tyr Asn 
    210                 215                 220                 


Ile Ser Asn Glu Ala Val Phe Asp Val Val Ser Leu Cys Pro Asn Leu 
225                 230                 235                 240 


Glu His Leu Asp Val Ser Gly Cys Ser Lys Val Thr Cys Ile Ser Leu 
                245                 250                 255     


Thr Arg Glu Ala Ser Ile Lys Leu Ser Pro Leu His Gly Lys Gln Ile 
            260                 265                 270         


Ser Ile Arg Tyr Leu Asp Met Thr Asp Cys Phe Val Leu Glu Asp Glu 
        275                 280                 285             


Gly Leu His Thr Ile Ala Ala His Cys Thr Gln Leu Thr His Leu Tyr 
    290                 295                 300                 


Leu Arg Arg Cys Val Arg Leu Thr Asp Glu Gly Leu Arg Tyr Leu Val 
305                 310                 315                 320 


Ile Tyr Cys Ala Ser Ile Lys Glu Leu Ser Val Ser Asp Cys Arg Phe 
                325                 330                 335     


Val Ser Asp Phe Gly Leu Arg Glu Ile Ala Lys Leu Glu Ser Arg Leu 
            340                 345                 350         


Arg Tyr Leu Ser Ile Ala His Cys Gly Arg Val Thr Asp Val Gly Ile 
        355                 360                 365             


Arg Tyr Val Ala Lys Tyr Cys Ser Lys Leu Arg Tyr Leu Asn Ala Arg 
    370                 375                 380                 


Gly Cys Glu Gly Ile Thr Asp His Gly Val Glu Tyr Leu Ala Lys Asn 
385                 390                 395                 400 


Cys Thr Lys Leu Lys Ser Leu Asp Ile Gly Lys Cys Pro Leu Val Ser 
                405                 410                 415     


Asp Thr Gly Leu Glu Cys Leu Ala Leu Asn Cys Phe Asn Leu Lys Arg 
            420                 425                 430         


Leu Ser Leu Lys Ser Cys Glu Ser Ile Thr Gly Gln Gly Leu Gln Ile 
        435                 440                 445             


Val Ala Ala Asn Cys Phe Asp Leu Gln Thr Leu Asn Val Gln Asp Cys 
    450                 455                 460                 


Glu Val Ser Val Glu Ala Leu Arg Phe Val Lys Arg His Cys Lys Arg 
465                 470                 475                 480 


Cys Val Ile Glu His Thr Asn Pro Ala Phe Phe 
                485                 490     


<210>  3931
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO10__Homo_sapiens__XP_005251496

<400>  3931

Met Glu Ala Gly Gly Leu Pro Leu Glu Leu Trp Arg Met Ile Leu Ala 
1               5                   10                  15      


Tyr Leu His Leu Pro Asp Leu Gly Arg Cys Ser Leu Val Cys Arg Ala 
            20                  25                  30          


Trp Tyr Glu Leu Ile Leu Ser Leu Asp Ser Thr Arg Trp Arg Gln Leu 
        35                  40                  45              


Cys Leu Gly Cys Thr Glu Cys Arg His Pro Asn Trp Pro Asn Gln Pro 
    50                  55                  60                  


Asp Val Glu Pro Glu Ser Trp Arg Glu Ala Phe Lys Gln His Tyr Leu 
65                  70                  75                  80  


Ala Ser Lys Thr Trp Thr Lys Asn Ala Leu Asp Leu Glu Ser Ser Ile 
                85                  90                  95      


Cys Phe Ser Leu Phe Arg Arg Arg Arg Glu Arg Arg Thr Leu Ser Val 
            100                 105                 110         


Gly Pro Gly Arg Glu Phe Asp Ser Leu Gly Ser Ala Leu Ala Met Ala 
        115                 120                 125             


Ser Leu Tyr Asp Arg Ile Val Leu Phe Pro Gly Val Tyr Glu Glu Gln 
    130                 135                 140                 


Gly Glu Ile Ile Leu Lys Val Pro Val Glu Ile Val Gly Gln Gly Lys 
145                 150                 155                 160 


Leu Gly Glu Val Ala Leu Leu Ala Ser Ile Asp Gln His Cys Ser Thr 
                165                 170                 175     


Thr Arg Leu Cys Asn Leu Val Phe Thr Pro Ala Trp Phe Ser Pro Ile 
            180                 185                 190         


Met Tyr Lys Thr Thr Ser Gly His Val Gln Phe Asp Asn Cys Asn Phe 
        195                 200                 205             


Glu Asn Gly His Ile Gln Val His Gly Pro Gly Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Cys Thr Phe Lys Asn Thr His Ile Phe Leu His Asn Val Pro Leu 
225                 230                 235                 240 


Cys Val Leu Glu Asn Cys Glu Phe Val Gly Ser Glu Asn Asn Ser Val 
                245                 250                 255     


Thr Val Glu Gly His Pro Ser Ala Asp Lys Asn Trp Ala Tyr Lys Tyr 
            260                 265                 270         


Leu Leu Gly Leu Ile Lys Ser Ser Pro Thr Phe Leu Pro Thr Glu Asp 
        275                 280                 285             


Ser Asp Phe Leu Met Ser Leu Asp Leu Glu Ser Arg Asp Gln Ala Trp 
    290                 295                 300                 


Ser Pro Lys Thr Cys Asp Ile Val Ile Glu Gly Ser Gln Ser Pro Thr 
305                 310                 315                 320 


Ser Pro Ala Ser Ser Ser Pro Lys Pro Gly Ser Lys Ala Gly Ser Gln 
                325                 330                 335     


Glu Ala Glu Val Gly Ser Asp Gly Glu Arg Val Ala Gln Thr Pro Asp 
            340                 345                 350         


Ser Ser Asp Gly Gly Leu Ser Pro Ser Gly Glu Asp Glu Asp Glu Asp 
        355                 360                 365             


Gln Leu Met Tyr Arg Leu Ser Tyr Gln Val Gln Gly Pro Arg Pro Val 
    370                 375                 380                 


Leu Gly Gly Ser Phe Leu Gly Pro Pro Leu Pro Gly Ala Ser Ile Gln 
385                 390                 395                 400 


Leu Pro Ser Cys Leu Val Leu Asn Ser Leu Gln Gln Glu Leu Gln Lys 
                405                 410                 415     


Asp Lys Glu Ala Met Ala Leu Ala Asn Ser Val Gln Gly Cys Leu Ile 
            420                 425                 430         


Arg Lys Cys Leu Phe Arg Asp Gly Lys Gly Gly Val Phe Val Cys Ser 
        435                 440                 445             


His Gly Arg Ala Lys Met Glu Gly Asn Ile Phe Arg Asn Leu Thr Tyr 
    450                 455                 460                 


Ala Val Arg Cys Ile His Asn Ser Lys Ile Ile Met Leu Arg Asn Asp 
465                 470                 475                 480 


Ile Tyr Arg Cys Arg Ala Ser Gly Ile Phe Leu Arg Leu Glu Gly Gly 
                485                 490                 495     


Gly Leu Ile Ala Gly Asn Asn Ile Tyr His Asn Ala Glu Ala Gly Val 
            500                 505                 510         


Asp Ile Arg Lys Lys Ser Asn Pro Leu Ile Leu Cys Asn Gln Ile His 
        515                 520                 525             


His Gly Leu Arg Ser Gly Ile Val Val Leu Gly Asn Gly Lys Gly Ile 
    530                 535                 540                 


Ile Arg Asn Asn Gln Ile Phe Ser Asn Lys Glu Ala Gly Ile Tyr Ile 
545                 550                 555                 560 


Leu Tyr His Gly Asn Pro Val Val Ser Gly Asn His Ile Phe Lys Gly 
                565                 570                 575     


Arg Ala Ala Gly Ile Ala Val Asn Glu Asn Gly Lys Gly Leu Ile Thr 
            580                 585                 590         


Glu Asn Val Ile Arg Glu Asn Gln Trp Gly Gly Val Asp Ile Arg Arg 
        595                 600                 605             


Gly Gly Ile Pro Val Leu Arg Ser Asn Leu Ile Cys Phe Gly Tyr Ser 
    610                 615                 620                 


Asp Gly Val Val Val Gly Asp Glu Gly Lys Gly Leu Ile Glu Gly Asn 
625                 630                 635                 640 


Thr Ile Tyr Glu Asn Gly Lys Tyr Asn Gly Lys Thr Arg 
                645                 650             


<210>  3932
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO11__Homo_sapiens__NP_001177203

<400>  3932

Met Asn Ser Val Arg Ala Ala Asn Arg Arg Pro Arg Arg Val Ser Arg 
1               5                   10                  15      


Pro Arg Pro Val Gln Gln Gln Gln Gln Gln Pro Pro Gln Gln Pro Pro 
            20                  25                  30          


Pro Gln Pro Pro Gln Gln Gln Pro Pro Gln Gln Gln Pro Pro Pro Pro 
        35                  40                  45              


Pro Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Pro Leu Pro Gln Glu Arg Asn Asn Val Gly Glu Arg Asp Asp Asp 
65                  70                  75                  80  


Val Pro Ala Asp Met Val Ala Glu Glu Ser Gly Pro Gly Ala Gln Asn 
                85                  90                  95      


Ser Pro Tyr Gln Leu Arg Arg Lys Thr Leu Leu Pro Lys Arg Thr Ala 
            100                 105                 110         


Cys Pro Thr Lys Asn Ser Met Glu Gly Ala Ser Thr Ser Thr Thr Glu 
        115                 120                 125             


Asn Phe Gly His Arg Ala Lys Arg Ala Arg Val Ser Gly Lys Ser Gln 
    130                 135                 140                 


Asp Leu Ser Ala Ala Pro Ala Glu Gln Tyr Leu Gln Glu Lys Leu Pro 
145                 150                 155                 160 


Asp Glu Val Val Leu Lys Ile Phe Ser Tyr Leu Leu Glu Gln Asp Leu 
                165                 170                 175     


Cys Arg Ala Ala Cys Val Cys Lys Arg Phe Ser Glu Leu Ala Asn Asp 
            180                 185                 190         


Pro Ile Leu Trp Lys Arg Leu Tyr Met Glu Val Phe Glu Tyr Thr Arg 
        195                 200                 205             


Pro Met Met His Pro Glu Pro Gly Lys Phe Tyr Gln Ile Asn Pro Glu 
    210                 215                 220                 


Glu Tyr Glu His Pro Asn Pro Trp Lys Glu Ser Phe Gln Gln Leu Tyr 
225                 230                 235                 240 


Lys Gly Ala His Val Lys Pro Gly Phe Ala Glu His Phe Tyr Ser Asn 
                245                 250                 255     


Pro Ala Arg Tyr Lys Gly Arg Glu Asn Met Leu Tyr Tyr Asp Thr Ile 
            260                 265                 270         


Glu Asp Ala Leu Gly Gly Val Gln Glu Ala His Phe Asp Gly Leu Ile 
        275                 280                 285             


Phe Val His Ser Gly Ile Tyr Thr Asp Glu Trp Ile Tyr Ile Glu Ser 
    290                 295                 300                 


Pro Ile Thr Met Ile Gly Ala Ala Pro Gly Lys Val Ala Asp Lys Val 
305                 310                 315                 320 


Ile Ile Glu Asn Thr Arg Asp Ser Thr Phe Val Phe Met Glu Gly Ser 
                325                 330                 335     


Glu Asp Ala Tyr Val Gly Tyr Met Thr Ile Arg Phe Asn Pro Asp Asp 
            340                 345                 350         


Lys Ser Ala Gln His His Asn Ala His His Cys Leu Glu Ile Thr Val 
        355                 360                 365             


Asn Cys Ser Pro Ile Ile Asp His Cys Ile Ile Arg Ser Thr Cys Thr 
    370                 375                 380                 


Val Gly Ser Ala Val Cys Val Ser Gly Gln Gly Ala Cys Pro Thr Ile 
385                 390                 395                 400 


Lys His Cys Asn Ile Ser Asp Cys Glu Asn Val Gly Leu Tyr Ile Thr 
                405                 410                 415     


Asp His Ala Gln Gly Ile Tyr Glu Asp Asn Glu Ile Ser Asn Asn Ala 
            420                 425                 430         


Leu Ala Gly Ile Trp Val Lys Asn His Gly Asn Pro Ile Ile Arg Arg 
        435                 440                 445             


Asn His Ile His His Gly Arg Asp Val Gly Val Phe Thr Phe Asp His 
    450                 455                 460                 


Gly Met Gly Tyr Phe Glu Ser Cys Asn Ile His Arg Asn Arg Ile Ala 
465                 470                 475                 480 


Gly Phe Glu Val Lys Ala Tyr Ala Asn Pro Thr Val Val Arg Cys Glu 
                485                 490                 495     


Ile His His Gly Gln Thr Gly Gly Ile Tyr Val His Glu Lys Gly Arg 
            500                 505                 510         


Gly Gln Phe Ile Glu Asn Lys Ile Tyr Ala Asn Asn Phe Ala Gly Val 
        515                 520                 525             


Trp Ile Thr Ser Asn Ser Asp Pro Thr Ile Arg Gly Asn Ser Ile Phe 
    530                 535                 540                 


Asn Gly Asn Gln Gly Gly Val Tyr Ile Phe Gly Asp Gly Arg Gly Leu 
545                 550                 555                 560 


Ile Glu Gly Asn Asp Ile Tyr Gly Asn Ala Leu Ala Gly Ile Gln Ile 
                565                 570                 575     


Arg Thr Asn Ser Cys Pro Ile Val Arg His Asn Lys Ile His Asp Gly 
            580                 585                 590         


Gln His Gly Gly Ile Tyr Val His Glu Lys Gly Gln Gly Val Ile Glu 
        595                 600                 605             


Glu Asn Glu Val Tyr Ser Asn Thr Leu Ala Gly Val Trp Val Thr Thr 
    610                 615                 620                 


Gly Ser Thr Pro Val Leu Arg Arg Asn Arg Ile His Ser Gly Lys Gln 
625                 630                 635                 640 


Val Gly Val Tyr Phe Tyr Asp Asn Gly His Gly Val Leu Glu Asp Asn 
                645                 650                 655     


Asp Ile Tyr Asn His Met Tyr Ser Gly Val Gln Ile Arg Thr Gly Ser 
            660                 665                 670         


Asn Pro Lys Ile Arg Arg Asn Lys Ile Trp Gly Gly Gln Asn Gly Gly 
        675                 680                 685             


Ile Leu Val Tyr Asn Ser Gly Leu Gly Cys Ile Glu Asp Asn Glu Ile 
    690                 695                 700                 


Phe Asp Asn Ala Met Ala Gly Val Trp Ile Lys Thr Asp Ser Asn Pro 
705                 710                 715                 720 


Thr Leu Arg Arg Asn Lys Ile His Asp Gly Arg Asp Gly Gly Ile Cys 
                725                 730                 735     


Ile Phe Asn Gly Gly Arg Gly Leu Leu Glu Glu Asn Asp Ile Phe Arg 
            740                 745                 750         


Asn Ala Gln Ala Gly Val Leu Ile Ser Thr Asn Ser His Pro Ile Leu 
        755                 760                 765             


Arg Lys Asn Arg Ile Phe Asp Gly Phe Ala Ala Gly Ile Glu Ile Thr 
    770                 775                 780                 


Asn His Ala Thr Ala Thr Leu Glu Gly Asn Gln Ile Phe Asn Asn Arg 
785                 790                 795                 800 


Phe Gly Gly Leu Phe Leu Ala Ser Gly Val Asn Val Thr Met Lys Asp 
                805                 810                 815     


Asn Lys Ile Met Asn Asn Gln Asp Ala Ile Glu Lys Ala Val Ser Arg 
            820                 825                 830         


Gly Gln Cys Leu Tyr Lys Ile Ser Ser Tyr Thr Ser Tyr Pro Met His 
        835                 840                 845             


Asp Phe Tyr Arg Cys His Thr Cys Asn Thr Thr Asp Arg Asn Ala Ile 
    850                 855                 860                 


Cys Val Asn Cys Ile Lys Lys Cys His Gln Gly His Asp Val Glu Phe 
865                 870                 875                 880 


Ile Arg His Asp Arg Phe Phe Cys Asp Cys Gly Ala Gly Thr Leu Ser 
                885                 890                 895     


Asn Pro Cys Thr Leu Ala Gly Glu Pro Thr His Asp Thr Asp Thr Leu 
            900                 905                 910         


Tyr Asp Ser Ala Pro Pro Ile Glu Ser Asn Thr Leu Gln His Asn 
        915                 920                 925         


<210>  3933
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO15__Homo_sapiens__NP_001136430

<400>  3933

Met Ala Thr Gly Arg Gly Arg Ile Leu Gln Gln His Trp Leu Gly Leu 
1               5                   10                  15      


Gln Thr Leu Arg Gly Pro Ser Arg Gly Gly Gly Ala Ala Arg Gly Arg 
            20                  25                  30          


Ala Arg Ala Phe Gly Cys Arg Lys Gly Pro Gly Val Lys Leu Ser Ala 
        35                  40                  45              


Gly Ser Ala Ala Leu Arg Cys His Ala Gly Gly Gly Gln His Trp Glu 
    50                  55                  60                  


Ser Ser Phe Ser Cys Cys Ser Gly Phe Leu Asp Gly Met Pro Ser Glu 
65                  70                  75                  80  


Ile Leu Leu Lys Ile Phe Ser Tyr Leu Asp Ala Val Ser Leu Leu Cys 
                85                  90                  95      


Thr Gly Cys Val Ser Arg Arg Phe Tyr His Leu Ala Asn Asp Asn Phe 
            100                 105                 110         


Ile Trp Ile Gly Ile Tyr Ser Thr Ala Phe Ser Pro Ala Arg Ser Asn 
        115                 120                 125             


Trp Lys Phe Asn Ser Val Glu Lys Ile Ala Met Ser Met Ser Phe Leu 
    130                 135                 140                 


Ser Val Gln Asp Lys Glu Ala Gly Tyr Trp Lys Lys Glu Tyr Ile Thr 
145                 150                 155                 160 


Lys Gln Ile Ala Ser Val Lys Ala Ala Leu Ala Asp Ile Leu Lys Pro 
                165                 170                 175     


Val Asn Pro Tyr Thr Gly Leu Pro Val Lys Thr Lys Glu Ala Leu Arg 
            180                 185                 190         


Ile Phe Gly Leu Gly Trp Ala Ile Ile Leu Lys Glu Lys Gly Gly Lys 
        195                 200                 205             


Glu Tyr Ile Met Glu His Val Asp Leu Ser Ile Asn Asp Thr Ser Val 
    210                 215                 220                 


Thr Val Ile Trp Tyr Gly Lys Lys Trp Pro Cys Leu Ala Ser Leu Ser 
225                 230                 235                 240 


Thr Leu Asp Leu Cys Gly Met Thr Pro Val Phe Thr Asp Trp Tyr Lys 
                245                 250                 255     


Thr Pro Thr Lys His Arg Leu Arg Trp His Ser Leu Ile Ala Lys Tyr 
            260                 265                 270         


Asn Leu Ser His Leu Thr Ile Ser Thr Met Ile Gly Cys Asp Arg Leu 
        275                 280                 285             


Ile Arg Ile Phe Cys Leu His Pro Gly Leu Leu Val Gly Val Trp Lys 
    290                 295                 300                 


Lys Glu Glu Glu Leu Ala Phe Val Met Ala Asn Leu His Phe His His 
305                 310                 315                 320 


Leu Val Glu Arg Ser Thr Leu Gly Ser Ala Thr Ile Pro Tyr Glu Leu 
                325                 330                 335     


Pro Pro His Ser Pro Phe Leu Asp Asp Ser Pro Glu Tyr Gly Leu His 
            340                 345                 350         


Gly Tyr Gln Leu His Val Asp Leu His Ser Gly Gly Val Phe Tyr Leu 
        355                 360                 365             


Cys Gly Thr Phe Arg Asn Leu Phe Thr Lys Arg Gly Asn Ile Glu Asn 
    370                 375                 380                 


Gly His Val Lys Leu Ile Val Ile His Leu Lys Asn Asn Arg Glu His 
385                 390                 395                 400 


Leu Pro Leu Ile Gly Lys Val Gly Leu Ser Trp Lys Thr Asp Ile Phe 
                405                 410                 415     


Asp Gly Cys Ile Lys Ser Cys Ser Met Met Asp Val Thr Leu Leu Asp 
            420                 425                 430         


Glu His Gly Lys Pro Phe Trp Cys Phe Ser Ser Pro Val Cys Leu Arg 
        435                 440                 445             


Ser Pro Ala Thr Pro Ser Asp Ser Ser Ser Phe Leu Gly Gln Thr Tyr 
    450                 455                 460                 


Asn Val Asp Tyr Val Asp Ala Glu Gly Arg Val His Val Glu Leu Val 
465                 470                 475                 480 


Trp Ile Arg Glu Thr Glu Glu Tyr Leu Ile Val Asn Leu Val Leu Tyr 
                485                 490                 495     


Leu Ser Ile Ala Lys Ile Asn His Trp Phe Gly Thr Glu Tyr 
            500                 505                 510 


<210>  3934
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO17__Homo_sapiens__NP_079183

<400>  3934

Met Gly Ala Arg Leu Ser Arg Arg Arg Leu Pro Ala Asp Pro Ser Leu 
1               5                   10                  15      


Ala Leu Asp Ala Leu Pro Pro Glu Leu Leu Val Gln Val Leu Ser His 
            20                  25                  30          


Val Pro Pro Arg Ser Leu Val Thr Arg Cys Arg Pro Val Cys Arg Ala 
        35                  40                  45              


Trp Arg Asp Ile Val Asp Gly Pro Thr Val Trp Leu Leu Gln Leu Ala 
    50                  55                  60                  


Arg Asp Arg Ser Ala Glu Gly Arg Ala Leu Tyr Ala Val Ala Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ser Asn Glu Asp Lys Glu Glu Phe Pro Leu Cys Ala Leu 
                85                  90                  95      


Ala Arg Tyr Cys Leu Arg Ala Pro Phe Gly Arg Asn Leu Ile Phe Asn 
            100                 105                 110         


Ser Cys Gly Glu Gln Gly Phe Arg Gly Trp Glu Val Glu His Gly Gly 
        115                 120                 125             


Asn Gly Trp Ala Ile Glu Lys Asn Leu Thr Pro Val Pro Gly Ala Pro 
    130                 135                 140                 


Ser Gln Thr Cys Phe Val Thr Ser Phe Glu Trp Cys Ser Lys Arg Gln 
145                 150                 155                 160 


Leu Val Asp Leu Val Met Glu Gly Val Trp Gln Glu Leu Leu Asp Ser 
                165                 170                 175     


Ala Gln Ile Glu Ile Cys Val Ala Asp Trp Trp Gly Ala Arg Glu Asn 
            180                 185                 190         


Cys Gly Cys Val Tyr Gln Leu Arg Val Arg Leu Leu Asp Val Tyr Glu 
        195                 200                 205             


Lys Glu Val Val Lys Phe Ser Ala Ser Pro Asp Pro Val Leu Gln Trp 
    210                 215                 220                 


Thr Glu Arg Gly Cys Arg Gln Val Ser His Val Phe Thr Asn Phe Gly 
225                 230                 235                 240 


Lys Gly Ile Arg Tyr Val Ser Phe Glu Gln Tyr Gly Arg Asp Val Ser 
                245                 250                 255     


Ser Trp Val Gly His Tyr Gly Ala Leu Val Thr His Ser Ser Val Arg 
            260                 265                 270         


Val Arg Ile Arg Leu Ser 
        275             


<210>  3935
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO18__Homo_sapiens__NP_001245381

<400>  3935

Met Ala Lys Ser Asn Ser Val Gly Gln Asp Ser Cys Gln Asp Ser Glu 
1               5                   10                  15      


Gly Asp Met Ile Phe Pro Ala Glu Ser Ser Cys Ala Leu Pro Gln Glu 
            20                  25                  30          


Gly Ser Ala Gly Pro Gly Ser Pro Gly Ser Ala Pro Pro Ser Arg Lys 
        35                  40                  45              


Arg Ser Trp Ser Ser Glu Glu Glu Ser Asn Gln Ala Thr Gly Thr Ser 
    50                  55                  60                  


Arg Trp Asp Gly Val Ser Lys Lys Ala Pro Arg His His Leu Ser Val 
65                  70                  75                  80  


Pro Cys Thr Arg Pro Arg Glu Ala Arg Gln Glu Ala Glu Asp Ser Thr 
                85                  90                  95      


Ser Arg Leu Ser Ala Glu Ser Gly Glu Thr Asp Gln Asp Ala Gly Asp 
            100                 105                 110         


Val Gly Pro Asp Pro Ile Pro Asp Ser Tyr Tyr Gly Leu Leu Gly Thr 
        115                 120                 125             


Leu Pro Cys Gln Glu Ala Leu Ser His Ile Cys Ser Leu Pro Ser Glu 
    130                 135                 140                 


Val Leu Arg His Val Phe Ala Phe Leu Pro Val Glu Asp Leu Tyr Trp 
145                 150                 155                 160 


Asn Leu Ser Leu Val Cys His Leu Trp Arg Glu Ile Ile Ser Asp Pro 
                165                 170                 175     


Leu Phe Ile Pro Trp Lys Lys Leu Tyr His Arg Tyr Leu Met Asn Glu 
            180                 185                 190         


Glu Gln Ala Val Ser Lys Val Asp Gly Ile Leu Ser Asn Cys Gly Ile 
        195                 200                 205             


Glu Lys Glu Ser Asp Leu Cys Val Leu Asn Leu Ile Arg Tyr Thr Ala 
    210                 215                 220                 


Thr Thr Lys Cys Ser Pro Ser Val Asp Pro Glu Arg Val Leu Trp Ser 
225                 230                 235                 240 


Leu Arg Asp His Pro Leu Leu Pro Glu Ala Glu Ala Cys Val Arg Gln 
                245                 250                 255     


His Leu Pro Asp Leu Tyr Ala Ala Ala Gly Gly Val Asn Ile Trp Ala 
            260                 265                 270         


Leu Val Ala Ala Val Val Leu Leu Ser Ser Ser Val Asn Asp Ile Gln 
        275                 280                 285             


Arg Leu Leu Phe Cys Leu Arg Arg Pro Ser Ser Thr Val Thr Met Pro 
    290                 295                 300                 


Asp Val Thr Glu Thr Leu Tyr Cys Ile Ala Val Leu Leu Tyr Ala Met 
305                 310                 315                 320 


Arg Glu Lys Gly Ile Asn Ile Ser Asn Arg Ile His Tyr Asn Ile Phe 
                325                 330                 335     


Tyr Cys Leu Tyr Leu Gln Glu Asn Ser Cys Thr Gln Ala Thr Lys Val 
            340                 345                 350         


Lys Glu Glu Pro Ser Val Trp Pro Gly Lys Lys Thr Ile Gln Leu Thr 
        355                 360                 365             


His Glu Gln Gln Leu Ile Leu Asn His Lys Met Glu Pro Leu Gln Val 
    370                 375                 380                 


Val Lys Ile Met Ala Phe Ala Gly Thr Gly Lys Thr Ser Thr Leu Val 
385                 390                 395                 400 


Lys Tyr Ala Glu Lys Trp Ser Gln Ser Arg Phe Leu Tyr Val Thr Phe 
                405                 410                 415     


Asn Lys Ser Ile Ala Lys Gln Ala Glu Arg Val Phe Pro Ser Asn Val 
            420                 425                 430         


Ile Cys Lys Thr Phe His Ser Met Ala Tyr Gly His Ile Gly Arg Lys 
        435                 440                 445             


Tyr Gln Ser Lys Lys Lys Leu Asn Leu Phe Lys Leu Thr Pro Phe Met 
    450                 455                 460                 


Val Asn Ser Val Leu Ala Glu Gly Lys Gly Gly Phe Ile Arg Ala Lys 
465                 470                 475                 480 


Leu Val Cys Lys Thr Leu Glu Asn Phe Phe Ala Ser Ala Asp Glu Glu 
                485                 490                 495     


Leu Thr Ile Asp His Val Pro Ile Trp Cys Lys Asn Ser Gln Gly Gln 
            500                 505                 510         


Arg Val Met Val Glu Gln Ser Glu Lys Leu Asn Gly Val Leu Glu Ala 
        515                 520                 525             


Ser Arg Leu Trp Asp Asn Met Arg Lys Leu Gly Glu Cys Thr Glu Glu 
    530                 535                 540                 


Ala His Gln Met Thr His Asp Gly Tyr Leu Lys Leu Trp Gln Leu Ser 
545                 550                 555                 560 


Lys Pro Ser Leu Ala Ser Phe Asp Ala Ile Phe Val Asp Glu Ala Gln 
                565                 570                 575     


Asp Cys Thr Pro Ala Ile Met Asn Ile Val Leu Ser Gln Pro Cys Gly 
            580                 585                 590         


Lys Ile Phe Val Gly Asp Pro His Gln Gln Ile Tyr Thr Phe Arg Gly 
        595                 600                 605             


Ala Val Asn Ala Leu Phe Thr Val Pro His Thr His Val Phe Tyr Leu 
    610                 615                 620                 


Thr Gln Ser Phe Arg Phe Gly Val Glu Ile Ala Tyr Val Gly Ala Thr 
625                 630                 635                 640 


Ile Leu Asp Val Cys Lys Arg Val Arg Lys Lys Thr Leu Val Gly Gly 
                645                 650                 655     


Asn His Gln Ser Gly Ile Arg Gly Asp Ala Lys Gly Gln Val Ala Leu 
            660                 665                 670         


Leu Ser Arg Thr Asn Ala Asn Val Phe Asp Glu Ala Val Arg Val Thr 
        675                 680                 685             


Glu Gly Glu Phe Pro Ser Arg Ile His Leu Ile Gly Gly Ile Lys Ser 
    690                 695                 700                 


Phe Gly Leu Asp Arg Ile Ile Asp Ile Trp Ile Leu Leu Gln Pro Glu 
705                 710                 715                 720 


Glu Glu Arg Arg Lys Gln Asn Leu Val Ile Lys Asp Lys Phe Ile Arg 
                725                 730                 735     


Arg Trp Val His Lys Glu Gly Phe Ser Gly Phe Lys Arg Tyr Val Thr 
            740                 745                 750         


Ala Ala Glu Asp Lys Glu Leu Glu Ala Lys Ile Ala Val Val Glu Lys 
        755                 760                 765             


Tyr Asn Ile Arg Ile Pro Glu Leu Val Gln Arg Ile Glu Lys Cys His 
    770                 775                 780                 


Ile Glu Asp Leu Asp Phe Ala Glu Met Glu Ser His His Val Gly Gln 
785                 790                 795                 800 


Ala Gly Leu Glu Leu Pro Thr Ser Glu Tyr Ile Leu Gly Thr Val His 
                805                 810                 815     


Lys Ala Lys Gly Leu Glu Phe Asp Thr Val His Val Leu Asp Asp Phe 
            820                 825                 830         


Val Lys Val Pro Cys Ala Arg His Asn Leu Pro Gln Leu Pro His Phe 
        835                 840                 845             


Arg Val Glu Ser Phe Ser Glu Asp Glu Trp Asn Leu Leu Tyr Val Ala 
    850                 855                 860                 


Val Thr Arg Ala Lys Lys Arg Leu Ile Met Thr Lys Ser Leu Glu Asn 
865                 870                 875                 880 


Ile Leu Thr Leu Ala Gly Glu Tyr Phe Leu Gln Ala Glu Leu Thr Ser 
                885                 890                 895     


Asn Val Leu Lys Thr Gly Val Val Arg Cys Cys Val Gly Gln Cys Asn 
            900                 905                 910         


Asn Ala Ile Pro Val Asp Thr Val Leu Thr Met Lys Lys Leu Pro Ile 
        915                 920                 925             


Thr Tyr Ser Asn Arg Lys Glu Asn Lys Gly Gly Tyr Leu Cys His Ser 
    930                 935                 940                 


Cys Ala Glu Gln Arg Ile Gly Pro Leu Ala Phe Leu Thr Ala Ser Pro 
945                 950                 955                 960 


Glu Gln Val Arg Ala Met Glu Arg Thr Val Glu Asn Ile Val Leu Pro 
                965                 970                 975     


Arg His Glu Ala Leu Leu Phe Leu Val Phe 
            980                 985     


<210>  3936
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO28__Homo_sapiens__NP_001129587

<400>  3936

Met Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly 
1               5                   10                  15      


Gln Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu 
        35                  40                  45              


Pro Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu 
    50                  55                  60                  


Val Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser 
65                  70                  75                  80  


Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu 
                85                  90                  95      


Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr 
            100                 105                 110         


His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu 
        115                 120                 125             


Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala 
    130                 135                 140                 


Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr 
145                 150                 155                 160 


Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Phe Gln Asp Arg 
                165                 170                 175     


Leu Gln Pro 
            


<210>  3937
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO30__Homo_sapiens__XP_005267216

<400>  3937

Met Glu Glu Glu Leu Gln His Ser His Cys Val Asn Cys Val Ser Arg 
1               5                   10                  15      


Arg Cys Met Thr Arg Pro Glu Pro Gly Ile Ser Cys Asp Leu Ile Gly 
            20                  25                  30          


Cys Pro Leu Val Cys Gly Ala Val Phe His Ser Cys Lys Ala Asp Glu 
        35                  40                  45              


His Arg Leu Leu Cys Pro Phe Glu Arg Val Pro Cys Leu Asn Ser Asp 
    50                  55                  60                  


Phe Gly Cys Pro Phe Thr Met Ala Arg Asn Lys Val Ala Glu His Leu 
65                  70                  75                  80  


Glu Met Cys Pro Ala Ser Val Val Cys Cys Thr Met Glu Trp Asn Arg 
                85                  90                  95      


Trp Pro Val Ser Tyr Ala Asp Arg Lys Ser Tyr Glu Asn Leu Ser Arg 
            100                 105                 110         


Asp Val Asp Glu Val Ala Gln Leu Asp Met Ala Leu Ala Leu Gln Asp 
        115                 120                 125             


Gln Arg Met Leu Leu Glu Ser Leu Lys Val Ala Thr Met Met Ser Lys 
    130                 135                 140                 


Ala Thr Asp Lys Val Ser Lys Pro Arg Glu Gln Ile Ser Val Lys Ser 
145                 150                 155                 160 


Ser Val Pro Glu Ile Pro His Ala Asn Gly Leu Val Ser Val Asp Glu 
                165                 170                 175     


Glu Ser Tyr Gly Ala Leu Tyr Gln Ala Thr Val Glu Thr Thr Arg Ser 
            180                 185                 190         


Leu Ala Ala Ala Leu Asp Ile Leu Asn Thr Ala Thr Arg Asp Ile Gly 
        195                 200                 205             


Met Leu Asn Thr Ser Val Pro Asn Asp Met Asp Glu Gln Gln Asn Ala 
    210                 215                 220                 


Arg Glu Ser Leu Glu Asp Gln Asn Leu Lys Asp Gln Asp His Leu Tyr 
225                 230                 235                 240 


Glu Glu Glu Ile Gly Ala Val Gly Gly Ile Asp Tyr Asn Asp Thr Asn 
                245                 250                 255     


Gln Asn Ala Gln Ser Glu Gln Asn Gly Ser Ser Asp Leu Leu Cys Asp 
            260                 265                 270         


Leu Asn Thr Ser Ser Tyr Asp Thr Ser Ala Leu Cys Asn Gly Phe Pro 
        275                 280                 285             


Leu Glu Asn Ile Cys Thr Gln Val Ile Asp Gln Asn Gln Asn Leu His 
    290                 295                 300                 


Gly Asp Ser Lys Gln Ser Asn Leu Thr Asn Gly Asp Cys Val Ala Ser 
305                 310                 315                 320 


Ser Asp Gly Thr Ser Lys Pro Ser Ser Ser Leu Ala Val Ala Ala Gln 
                325                 330                 335     


Leu Arg Glu Ile Ile Pro Ser Ser Ala Leu Pro Asn Gly Thr Val Gln 
            340                 345                 350         


His Ile Leu Met Pro Asp Asp Glu Gly Glu Gly Glu Leu Cys Trp Lys 
        355                 360                 365             


Lys Val Asp Leu Gly Asp Val Lys Asn Val Asp Val Leu Ser Phe Ser 
    370                 375                 380                 


His Ala Pro Ser Phe Asn Phe Leu Ser Asn Ser Cys Trp Ser Lys Pro 
385                 390                 395                 400 


Lys Glu Asp Lys Ala Val Asp Thr Ser Asp Leu Glu Val Ala Glu Asp 
                405                 410                 415     


Pro Met Gly Leu Gln Gly Ile Asp Leu Ile Thr Ala Ala Leu Leu Phe 
            420                 425                 430         


Cys Leu Gly Asp Ser Pro Gly Gly Arg Gly Ile Ser Asp Ser Arg Met 
        435                 440                 445             


Ala Asp Ile Tyr His Ile Asp Val Gly Thr Gln Thr Phe Ser Leu Pro 
    450                 455                 460                 


Ser Ala Ile Leu Ala Thr Ser Thr Met Val Gly Glu Ile Ala Ser Ala 
465                 470                 475                 480 


Ser Ala Cys Asp His Ala Asn Pro Gln Leu Ser Asn Pro Ser Pro Phe 
                485                 490                 495     


Gln Thr Leu Gly Leu Asp Leu Val Leu Glu Cys Val Ala Arg Tyr Gln 
            500                 505                 510         


Pro Lys Gln Arg Ser Met Phe Thr Phe Val Cys Gly Gln Leu Phe Arg 
        515                 520                 525             


Arg Lys Glu Phe Ser Ser His Phe Lys Asn Val His Gly Asp Ile His 
    530                 535                 540                 


Ala Gly Leu Asn Gly Trp Met Glu Gln Arg Cys Pro Leu Ala Tyr Tyr 
545                 550                 555                 560 


Gly Cys Thr Tyr Ser Gln Arg Arg Phe Cys Pro Ser Ile Gln Gly Ala 
                565                 570                 575     


Lys Ile Ile His Asp Arg His Leu Arg Ser Phe Gly Val Gln Pro Cys 
            580                 585                 590         


Val Ser Thr Val Leu Val Glu Pro Ala Arg Asn Cys Val Leu Gly Leu 
        595                 600                 605             


His Asn Asp His Leu Ser Ser Leu Pro Phe Glu Val Leu Gln His Ile 
    610                 615                 620                 


Ala Gly Phe Leu Asp Gly Phe Ser Leu Cys Gln Leu Ser Cys Val Ser 
625                 630                 635                 640 


Lys Leu Met Arg Asp Val Cys Gly Ser Leu Leu Gln Ser Arg Gly Met 
                645                 650                 655     


Val Ile Leu Gln Trp Gly Lys Arg Lys Tyr Pro Glu Gly Asn Ser Ser 
            660                 665                 670         


Trp Gln Ile Lys Glu Lys Val Trp Arg Phe Ser Thr Ala Phe Cys Ser 
        675                 680                 685             


Val Asn Glu Trp Lys Phe Ala Asp Ile Leu Ser Met Ala Asp His Leu 
    690                 695                 700                 


Lys Lys Cys Ser Tyr Asn Val Val Glu Lys Arg Glu Glu Ala Ile Pro 
705                 710                 715                 720 


Leu Pro Cys Met Cys Val Thr Arg Glu Leu Thr Lys Glu Gly Arg Ser 
                725                 730                 735     


Leu Arg Ser Val Leu Lys Pro Val Leu 
            740                 745 


<210>  3938
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO31__Homo_sapiens__NP_001269612

<400>  3938

Met Tyr Leu Pro Pro His Asp Pro His Val Asp Asp Pro Met Arg Phe 
1               5                   10                  15      


Lys Pro Leu Phe Arg Ile His Leu Met Glu Arg Lys Ala Ala Thr Val 
            20                  25                  30          


Glu Cys Met Tyr Gly His Lys Gly Pro His His Gly His Ile Gln Ile 
        35                  40                  45              


Val Lys Lys Asp Glu Phe Ser Thr Lys Cys Asn Gln Thr Asp His His 
    50                  55                  60                  


Arg Met Ser Gly Gly Arg Gln Glu Glu Phe Arg Thr Trp Leu Arg Glu 
65                  70                  75                  80  


Glu Trp Gly Arg Thr Leu Glu Asp Ile Phe His Glu His Met Gln Glu 
                85                  90                  95      


Leu Ile Leu Met Lys Phe Ile Tyr Thr Ser Gln Tyr Asp Asn Cys Leu 
            100                 105                 110         


Thr Tyr Arg Arg Ile Tyr Leu Pro Pro Ser Arg Pro Asp Asp Leu Ile 
        115                 120                 125             


Lys Pro Gly Leu Phe Lys Gly Thr Tyr Gly Ser His Gly Leu Glu Ile 
    130                 135                 140                 


Val Met Leu Ser Phe His Gly Arg Arg Ala Arg Gly Thr Lys Ile Thr 
145                 150                 155                 160 


Gly Asp Pro Asn Ile Pro Ala Gly Gln Gln Thr Val Glu Ile Asp Leu 
                165                 170                 175     


Arg His Arg Ile Gln Leu Pro Asp Leu Glu Asn Gln Arg Asn Phe Asn 
            180                 185                 190         


Glu Leu Ser Arg Ile Val Leu Glu Val Arg Glu Arg Val Arg Gln Glu 
        195                 200                 205             


Gln Gln Glu Gly Gly His Glu Ala Gly Glu Gly Arg Gly Arg Gln Gly 
    210                 215                 220                 


Pro Arg Glu Ser Gln Pro Ser Pro Ala Gln Pro Arg Ala Glu Ala Pro 
225                 230                 235                 240 


Ser Lys Gly Pro Asp Gly Thr Pro Gly Glu Asp Gly Gly Glu Pro Gly 
                245                 250                 255     


Asp Ala Val Ala Ala Ala Glu Gln Pro Ala Gln Cys Gly Gln Gly Gln 
            260                 265                 270         


Pro Phe Val Leu Pro Val Gly Val Ser Ser Arg Asn Glu Asp Tyr Pro 
        275                 280                 285             


Arg Thr Cys Arg Met Cys Phe Tyr Gly Thr Gly Leu Ile Ala Gly His 
    290                 295                 300                 


Gly Phe Thr Ser Pro Glu Arg Thr Pro Gly Val Phe Ile Leu Phe Asp 
305                 310                 315                 320 


Glu Asp Arg Phe Gly Phe Val Trp Leu Glu Leu Lys Ser Phe Ser Leu 
                325                 330                 335     


Tyr Ser Arg Val Gln Ala Thr Phe Arg Asn Ala Asp Ala Pro Ser Pro 
            340                 345                 350         


Gln Ala Phe Asp Glu Met Leu Lys Asn Ile Gln Ser Leu Thr Ser 
        355                 360                 365         


<210>  3939
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO32__Homo_sapiens__NP_001229392

<400>  3939

Met Pro Phe Leu Gly Gln Asp Trp Arg Ser Pro Gly Gln Asn Trp Val 
1               5                   10                  15      


Lys Thr Ala Asp Gly Trp Lys Arg Phe Leu Asp Glu Lys Ser Gly Ser 
            20                  25                  30          


Phe Val Ser Asp Leu Ser Ser Tyr Cys Asn Lys Glu Val Tyr Asn Lys 
        35                  40                  45              


Glu Asn Leu Phe Asn Ser Leu Asn Tyr Asp Val Ala Ala Lys Lys Arg 
    50                  55                  60                  


Lys Lys Asp Met Leu Asn Ser Lys Thr Lys Thr Gln Tyr Phe His Gln 
65                  70                  75                  80  


Glu Lys Trp Ile Tyr Val His Lys Gly Ser Thr Lys Glu Arg His Gly 
                85                  90                  95      


Tyr Cys Thr Leu Gly Glu Ala Phe Asn Arg Leu Asp Phe Ser Thr Ala 
            100                 105                 110         


Ile Leu Asp Ser Arg Arg Phe Asn Tyr Val Val Arg Pro Ala Phe Lys 
        115                 120                 125             


Gly Leu Thr Phe Thr Asp Leu Pro Leu Cys Leu Gln Leu Asn Ile Met 
    130                 135                 140                 


Gln Arg Leu Ser Asp Gly Arg Asp Leu Val Ser Leu Gly Gln Ala Ala 
145                 150                 155                 160 


Pro Asp Leu His Val Leu Ser Glu Asp Arg Leu Leu Trp Lys Lys Leu 
                165                 170                 175     


Cys Gln Tyr His Phe Ser Glu Arg Gln Ile Arg Lys Arg Leu Ile Leu 
            180                 185                 190         


Ser Asp Lys Gly Gln Leu Asp Trp Lys Lys Met Tyr Phe Lys Leu Val 
        195                 200                 205             


Arg Cys Tyr Pro Arg Lys Glu Gln Tyr Gly Asp Thr Leu Gln Leu Cys 
    210                 215                 220                 


Lys His Cys His Ile Leu Ser Trp Lys Gly Thr Asp His Pro Cys Thr 
225                 230                 235                 240 


Ala Asn Asn Pro Glu Ser Cys Ser Val Ser Leu Ser Pro Gln Asp Phe 
                245                 250                 255     


Ile Asn Leu Phe Lys Phe 
            260         


<210>  3940
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO33__Homo_sapiens__NP_976046

<400>  3940

Met Leu Leu Phe Leu Ser Val Pro Gln Pro Arg Pro Pro Gly Ala Arg 
1               5                   10                  15      


Thr Arg Ala Gly Ala Ala Arg Val Ala Arg Trp Arg Arg Leu Arg Leu 
            20                  25                  30          


Gln Gln Leu Arg Arg Leu Arg Gly Leu Leu Arg Val Leu Arg Gly Arg 
        35                  40                  45              


Pro Gly Ala Gly Ser Arg Arg Arg Gly Arg Met Ala Leu Cys Gly Gln 
    50                  55                  60                  


Ala Ala Gly Ala Ala Ser Leu Pro Ser Glu Leu Ile Val His Ile Phe 
65                  70                  75                  80  


Ser Phe Leu Pro Ala Pro Asp Arg Leu Arg Ala Ser Ala Ser Cys Ser 
                85                  90                  95      


His Trp Arg Glu Cys Leu Phe Tyr Pro Ala Leu Trp Pro Gln Leu Arg 
            100                 105                 110         


Ile Cys Leu Arg Val Ser Pro Ala Glu Gln Pro Arg Leu Glu Phe Leu 
        115                 120                 125             


Met Arg Lys Cys Gly Trp Phe Val Arg Glu Leu Arg Val Glu Phe Ala 
    130                 135                 140                 


Ala Glu Asn Tyr Leu Ser Gly Gly Gly Pro Gly Asp Gly Gly Gly Ala 
145                 150                 155                 160 


Asp Thr Gly Thr Gly Gly Glu Glu Val Glu Ala Leu Gln Leu Ser Ala 
                165                 170                 175     


Arg Trp Leu Glu Val Leu Arg Thr Tyr Leu Glu Leu Val Leu Cys Val 
            180                 185                 190         


Leu Val Ser Ile Arg Asn Asn Arg Asn Leu Gln Lys Phe Ser Leu Phe 
        195                 200                 205             


Gly Asp Ile Ser Val Leu Gln Gln Gln Gly Ser Leu Ser Asn Thr Tyr 
    210                 215                 220                 


Leu Ser Lys Val Asp Pro Asp Gly Lys Lys Ile Lys Gln Ile Gln Gln 
225                 230                 235                 240 


Leu Phe Glu Glu Ile Leu Ser Asn Ser Arg Gln Leu Lys Trp Leu Ser 
                245                 250                 255     


Cys Gly Phe Met Leu Glu Ile Val Thr Pro Thr Ser Leu Ser Ser Leu 
            260                 265                 270         


Ser Asn Ala Val Ala Asn Thr Met Glu His Leu Ser Leu Leu Asp Asn 
        275                 280                 285             


Asn Ile Pro Gly Asn Ser Thr Leu Ile Thr Ala Val Glu Leu Glu Arg 
    290                 295                 300                 


Phe Val Asn Leu His Ser Leu Ala Leu Asp Phe Cys Asp Phe Thr Ala 
305                 310                 315                 320 


Glu Met Ala Arg Val Leu Thr Asp Ser Asn His Val Pro Leu Gln Arg 
                325                 330                 335     


Leu Ser Leu Leu Val His Asn Val Ser Val Met His Lys Ser Leu Asp 
            340                 345                 350         


Asn Met Pro Asn Asp Glu His Trp Lys Ala Leu Ser Arg Lys Ser Thr 
        355                 360                 365             


Ser Phe Arg Val Tyr Ile Met Ala Phe Asp Ile Lys Ser Glu Asp Met 
    370                 375                 380                 


Leu Lys Ile Leu Lys Pro Ser Ile Pro Leu Glu Arg Ile His Phe Asp 
385                 390                 395                 400 


Ser Tyr Ile Thr Cys Val Ser Gly Ala Ile Val Asp Leu Ile Ser Arg 
                405                 410                 415     


Gln Tyr Asp Lys Phe Leu Thr His Phe Ile Leu Met Asn Asp Val Ile 
            420                 425                 430         


Asp Thr Ser Gly Phe Pro Asp Leu Ser Asp Asn Arg Asn Glu Asp Pro 
        435                 440                 445             


Leu Val Leu Leu Ala Trp Arg Cys Thr Lys Leu Ser Leu Leu Ala Ile 
    450                 455                 460                 


His Gly Tyr Thr Val Trp Ala His Asn Leu Ile Ala Ile Ala Arg Leu 
465                 470                 475                 480 


Arg Gly Ser Asp Leu Lys Val Leu Glu Val Thr Glu Glu Ser Ile Asp 
                485                 490                 495     


Phe Asp Gln Gly Glu Leu Ala Asp Gln Asp Val Asp Pro Val His Asn 
            500                 505                 510         


Leu Ile Glu Gln Val Ser Leu Gly Leu Gly Gln Pro Trp His Ala Val 
        515                 520                 525             


Met Asp Ile Glu Ser Leu Ser Val Phe Thr Glu Pro Asn Arg His Phe 
    530                 535                 540                 


Tyr Arg Glu Met Gln Ser Phe Ser Glu Asp Ile 
545                 550                 555 


<210>  3941
<211>  943
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO38__Homo_sapiens__NP_001258652

<400>  3941

Met Gly Pro Arg Lys Lys Ser Val Lys Thr Cys Ile Met Asn Asn Glu 
1               5                   10                  15      


Ile Pro Glu Glu Met Thr Ala Asp Glu Thr Lys Asp Tyr Met Asn Gln 
            20                  25                  30          


Leu Ser His Glu Val Leu Cys His Ile Phe Arg Tyr Leu Pro Leu Gln 
        35                  40                  45              


Asp Ile Met Cys Met Glu Cys Leu Ser Arg Lys Leu Lys Glu Ala Val 
    50                  55                  60                  


Thr Leu Tyr Leu Arg Val Val Arg Val Val Asp Leu Cys Ala Gly Arg 
65                  70                  75                  80  


Trp Trp Glu Tyr Met Pro Ser Gly Phe Thr Asp Ala Ser Phe Leu Thr 
                85                  90                  95      


Leu Leu Lys Lys Met Pro Asp Val Glu Gln Leu Tyr Gly Leu His Pro 
            100                 105                 110         


Arg Tyr Leu Glu Arg Arg Arg Val Arg Gly His Glu Ala Phe Ser Ile 
        115                 120                 125             


Pro Gly Val Leu Glu Ala Leu Gln Ala Cys Pro Asn Leu Val Gly Val 
    130                 135                 140                 


Glu Thr Ser His Leu Glu Leu Val Glu Ser Ile Trp Thr Tyr Met Pro 
145                 150                 155                 160 


His Val His Ile Leu Gly Lys Phe Arg Asn Arg Asn Gly Ala Phe Pro 
                165                 170                 175     


Ile Pro Pro Glu Asn Lys Leu Lys Ile Pro Ile Gly Ala Lys Ile Gln 
            180                 185                 190         


Thr Leu His Leu Val Gly Val Asn Val Pro Glu Ile Pro Cys Ile Pro 
        195                 200                 205             


Met Leu Arg His Leu Tyr Met Lys Trp Val Arg Leu Thr Lys Pro Gln 
    210                 215                 220                 


Pro Phe Lys Asp Phe Leu Cys Ile Ser Leu Arg Thr Phe Val Met Arg 
225                 230                 235                 240 


Asn Cys Ala Gly Pro Thr Asn Ser Leu Lys Tyr Val Pro Leu Val Thr 
                245                 250                 255     


Gly Leu Ala Ser Ala Arg Asn Leu Glu His Leu Glu Met Val Arg Val 
            260                 265                 270         


Pro Phe Leu Gly Gly Leu Ile Gln His Val Val Glu Asp Ser Trp Arg 
        275                 280                 285             


Ser Gly Gly Phe Arg Asn Leu His Thr Ile Val Leu Gly Ala Cys Lys 
    290                 295                 300                 


Asn Ala Leu Glu Val Asp Leu Gly Tyr Leu Ile Ile Thr Ala Ala Arg 
305                 310                 315                 320 


Arg Leu His Glu Val Arg Ile Gln Pro Ser Leu Thr Lys Asp Gly Val 
                325                 330                 335     


Phe Ser Ala Leu Lys Met Ala Glu Leu Glu Phe Pro Gln Phe Glu Thr 
            340                 345                 350         


Leu His Leu Gly Tyr Val Asp Glu Phe Leu Leu Gln Ser Arg Met Ala 
        355                 360                 365             


Asn Ala Asp Leu Val Lys Tyr Gly Leu Ala Asp Val Val Glu Asn Pro 
    370                 375                 380                 


Gly Ile Ile Thr Asp Ile Gly Met Lys Ala Val Asn Glu Val Phe Ser 
385                 390                 395                 400 


Cys Ile Lys Tyr Leu Ala Ile Tyr Asn Cys Pro His Leu His Asn Pro 
                405                 410                 415     


Tyr Asn Trp Ile Ser Asp His Ser Arg Trp Thr Arg Leu Val Asp Ile 
            420                 425                 430         


Asn Leu Val Arg Cys His Ala Leu Lys Leu Asp Ser Phe Gly Gln Phe 
        435                 440                 445             


Ile Glu Leu Leu Pro Ser Leu Glu Phe Ile Ser Leu Asp Gln Met Phe 
    450                 455                 460                 


Arg Glu Pro Pro Lys Gly Cys Ala Arg Val Gly Leu Ser Ala Gly Thr 
465                 470                 475                 480 


Gly Ile Gly Val Ser Ser Ala Leu Val Ser Asn Gln Asn Ser Asn Asn 
                485                 490                 495     


Asp Asp Asn Asn Ala Gln Asn Asn Asn Ala Asn Ile His Asp Asn Asn 
            500                 505                 510         


His His His Pro Asp Asp Ser Asp Glu Glu Asn Asp Phe Arg Gln Asp 
        515                 520                 525             


Leu Gln Pro Gly Glu Gln Gln Phe Ala Ala Asp Ala Leu Asn Glu Met 
    530                 535                 540                 


Glu Asp Ile Val Gln Glu Asp Gly Glu Val Val Ala Glu Ser Gly Asn 
545                 550                 555                 560 


Asn Thr Pro Ala His Ser Gln Ala Ile Ile Pro Val Asp Val Asp Glu 
                565                 570                 575     


Glu Gln Ala Gly Pro Ser Gly Leu Gln Arg Val Val Lys Pro Thr Ser 
            580                 585                 590         


Ile Thr Val His Asp Ser Glu Ser Asp Asp Glu Glu Asp Ser Leu Glu 
        595                 600                 605             


Leu Gln Glu Val Trp Ile Pro Lys Asn Gly Thr Arg Arg Tyr Ser Glu 
    610                 615                 620                 


Arg Glu Glu Lys Thr Gly Glu Ser Val Gln Ser Arg Glu Leu Ser Glu 
625                 630                 635                 640 


Val Ala Lys Thr Lys Pro Arg His Ala Met Lys Arg Lys Arg Thr Ala 
                645                 650                 655     


Asp Lys Ser Thr Ser Thr Ser Asp Pro Val Ile Glu Asp Asp His Val 
            660                 665                 670         


Gln Val Leu Val Leu Lys Ser Lys Asn Leu Val Gly Val Thr Met Thr 
        675                 680                 685             


Asn Cys Gly Ile Thr Asp Leu Val Leu Lys Asp Cys Pro Lys Met Met 
    690                 695                 700                 


Phe Ile His Ala Thr Arg Cys Arg Val Leu Lys His Leu Lys Val Glu 
705                 710                 715                 720 


Asn Ala Pro Ile Val Asn Arg Phe Asp Tyr Ala Gln Cys Lys Lys Leu 
                725                 730                 735     


Asn Met Asp Gln Val Leu Asp Gln Ile Leu Arg Met Pro Pro Glu Arg 
            740                 745                 750         


Asn Arg Ile Ile Tyr Leu Arg Pro Met Gln Gln Val Asp Thr Leu Thr 
        755                 760                 765             


Leu Glu Gln Lys Leu Phe Ser Gly Pro Tyr Pro Tyr His Ile Cys Ile 
    770                 775                 780                 


Ile His Glu Phe Ser Asn Pro Pro Asn Val Arg Asn Lys Val Arg Ile 
785                 790                 795                 800 


Arg Ser Trp Met Asp Thr Ile Ala Asn Ile Asn Gln Glu Leu Ile Lys 
                805                 810                 815     


Tyr Glu Phe Phe Pro Glu Ala Thr Arg Ser Glu Glu Asp Leu Lys Lys 
            820                 825                 830         


Tyr Pro Lys Tyr Pro Trp Gly Arg Glu Ile Tyr Thr Leu Glu Gly Val 
        835                 840                 845             


Val Asp Gly Ala Pro Tyr Ser Met Ile Ser Asp Phe Pro Trp Leu Arg 
    850                 855                 860                 


Ser Leu Arg Ala Ala Glu Pro Asn Ser Phe Ala Arg Tyr Asp Phe Glu 
865                 870                 875                 880 


Asp Asp Glu Glu Ser Thr Ile Tyr Ala Pro Arg Arg Lys Gly Gln Leu 
                885                 890                 895     


Ser Ala Asp Ile Cys Met Glu Thr Ile Gly Glu Glu Ile Ser Glu Met 
            900                 905                 910         


Arg Gln Met Lys Lys Gly Val Phe Gln Arg Val Val Ala Ile Phe Ile 
        915                 920                 925             


His Tyr Cys Asp Val Asn Gly Glu Pro Val Glu Asp Asp Tyr Ile 
    930                 935                 940             


<210>  3942
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO3__Homo_sapiens__NP_036307

<400>  3942

Met Ala Ala Met Glu Thr Glu Thr Ala Pro Leu Thr Leu Glu Ser Leu 
1               5                   10                  15      


Pro Thr Asp Pro Leu Leu Leu Ile Leu Ser Phe Leu Asp Tyr Arg Asp 
            20                  25                  30          


Leu Ile Asn Cys Cys Tyr Val Ser Arg Arg Leu Ser Gln Leu Ser Ser 
        35                  40                  45              


His Asp Pro Leu Trp Arg Arg His Cys Lys Lys Tyr Trp Leu Ile Ser 
    50                  55                  60                  


Glu Glu Glu Lys Thr Gln Lys Asn Gln Cys Trp Lys Ser Leu Phe Ile 
65                  70                  75                  80  


Asp Thr Tyr Ser Asp Val Gly Arg Tyr Ile Asp His Tyr Ala Ala Ile 
                85                  90                  95      


Lys Lys Ala Trp Asp Asp Leu Lys Lys Tyr Leu Glu Pro Arg Cys Pro 
            100                 105                 110         


Arg Met Val Leu Ser Leu Lys Glu Gly Ala Arg Glu Glu Asp Leu Asp 
        115                 120                 125             


Ala Val Glu Ala Gln Ile Gly Cys Lys Leu Pro Asp Asp Tyr Arg Cys 
    130                 135                 140                 


Ser Tyr Arg Ile His Asn Gly Gln Lys Leu Val Val Pro Gly Leu Leu 
145                 150                 155                 160 


Gly Ser Met Ala Leu Ser Asn His Tyr Arg Ser Glu Asp Leu Leu Asp 
                165                 170                 175     


Val Asp Thr Ala Ala Gly Gly Phe Gln Gln Arg Gln Gly Leu Lys Tyr 
            180                 185                 190         


Cys Leu Pro Leu Thr Phe Cys Ile His Thr Gly Leu Ser Gln Tyr Ile 
        195                 200                 205             


Ala Val Glu Ala Ala Glu Gly Arg Asn Lys Asn Glu Val Phe Tyr Gln 
    210                 215                 220                 


Cys Pro Asp Gln Met Ala Arg Asn Pro Ala Ala Ile Asp Met Phe Ile 
225                 230                 235                 240 


Ile Gly Ala Thr Phe Thr Asp Trp Phe Thr Ser Tyr Val Lys Asn Val 
                245                 250                 255     


Val Ser Gly Gly Phe Pro Ile Ile Arg Asp Gln Ile Phe Arg Tyr Val 
            260                 265                 270         


His Asp Pro Glu Cys Val Ala Thr Thr Gly Asp Ile Thr Val Ser Val 
        275                 280                 285             


Ser Thr Ser Phe Leu Pro Glu Leu Ser Ser Val His Pro Pro His Tyr 
    290                 295                 300                 


Phe Phe Thr Tyr Arg Ile Arg Ile Glu Met Ser Lys Asp Ala Leu Pro 
305                 310                 315                 320 


Glu Lys Ala Cys Gln Leu Asp Ser Arg Tyr Trp Arg Ile Thr Asn Ala 
                325                 330                 335     


Lys Gly Asp Val Glu Glu Val Gln Gly Pro Gly Val Val Gly Glu Phe 
            340                 345                 350         


Pro Ile Ile Ser Pro Gly Arg Val Tyr Glu Tyr Thr Ser Cys Thr Thr 
        355                 360                 365             


Phe Ser Thr Thr Ser Gly Tyr Met Glu Gly Tyr Tyr Thr Phe His Phe 
    370                 375                 380                 


Leu Tyr Phe Lys Asp Lys Ile Phe Asn Val Ala Ile Pro Arg Phe His 
385                 390                 395                 400 


Met Ala Cys Pro Thr Phe Arg Val Ser Ile Ala Arg Leu Glu Met Gly 
                405                 410                 415     


Pro Asp Glu Tyr Glu Glu Met Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Glu Asp Glu Asp Asp Asp Ser Ala Asp Met Asp Glu Ser Asp Glu Asp 
        435                 440                 445             


Asp Glu Glu Glu Arg Arg Arg Arg Val Phe Asp Val Pro Ile Arg Arg 
    450                 455                 460                 


Arg Arg Cys Ser Arg Leu Phe 
465                 470     


<210>  3943
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO40__Homo_sapiens__NP_057382

<400>  3943

Met Gly Lys Ala Arg Arg Ser Pro Pro Gly His His Arg His Cys Glu 
1               5                   10                  15      


Gly Cys Phe Asn Arg His Cys His Ile Pro Val Glu Pro Asn Thr Ser 
            20                  25                  30          


Cys Leu Val Ile Ser Cys His Leu Leu Cys Gly Ala Thr Phe His Met 
        35                  40                  45              


Cys Lys Glu Ala Glu His Gln Leu Leu Cys Pro Leu Glu Gln Val Pro 
    50                  55                  60                  


Cys Leu Asn Ser Glu Tyr Gly Cys Pro Leu Ser Met Ser Arg His Lys 
65                  70                  75                  80  


Leu Ala Lys His Leu Gln Val Cys Pro Ala Ser Val Val Cys Cys Ser 
                85                  90                  95      


Met Glu Trp Asn Arg Trp Pro Asn Val Asp Ser Glu Thr Thr Leu His 
            100                 105                 110         


Glu Asn Ile Met Lys Glu Thr Pro Ser Glu Glu Cys Leu Asp Thr Ala 
        115                 120                 125             


Leu Ala Leu Gln Asp Gln Lys Val Leu Phe Arg Ser Leu Lys Met Val 
    130                 135                 140                 


Glu Leu Phe Pro Glu Thr Arg Glu Ala Thr Glu Glu Glu Pro Thr Met 
145                 150                 155                 160 


Asn Gly Glu Thr Ser Val Glu Glu Met Gly Gly Ala Val Gly Gly Val 
                165                 170                 175     


Asp Ile Gly Leu Val Pro His Gly Leu Ser Ala Thr Asn Gly Glu Met 
            180                 185                 190         


Ala Glu Leu Ser Gln Glu Glu Arg Glu Val Leu Ala Lys Thr Lys Glu 
        195                 200                 205             


Gly Met Asp Leu Val Lys Phe Gly Gln Trp Glu Asn Ile Phe Ser Lys 
    210                 215                 220                 


Glu His Ala Ala Ser Ala Leu Thr Asn Ser Ser Ala Ser Cys Glu Ser 
225                 230                 235                 240 


Lys Asn Lys Asn Asp Ser Glu Lys Glu Gln Ile Ser Ser Gly His Asn 
                245                 250                 255     


Met Val Glu Gly Glu Gly Ala Pro Lys Lys Lys Glu Pro Gln Glu Asn 
            260                 265                 270         


Gln Lys Gln Gln Asp Val Arg Thr Ala Met Glu Thr Thr Gly Leu Ala 
        275                 280                 285             


Pro Trp Gln Asp Gly Val Leu Glu Arg Leu Lys Thr Ala Val Asp Ala 
    290                 295                 300                 


Lys Asp Tyr Asn Met Tyr Leu Val His Asn Gly Arg Met Leu Ile His 
305                 310                 315                 320 


Phe Gly Gln Met Pro Ala Cys Thr Pro Lys Glu Arg Asp Phe Val Tyr 
                325                 330                 335     


Gly Lys Leu Glu Ala Gln Glu Val Lys Thr Val Tyr Thr Phe Lys Val 
            340                 345                 350         


Pro Val Ser Tyr Cys Gly Lys Arg Ala Arg Leu Gly Asp Ala Met Leu 
        355                 360                 365             


Ser Cys Lys Pro Ser Glu His Lys Ala Val Asp Thr Ser Asp Leu Gly 
    370                 375                 380                 


Ile Thr Val Glu Asp Leu Pro Lys Ser Asp Leu Ile Lys Thr Thr Leu 
385                 390                 395                 400 


Gln Cys Ala Leu Glu Arg Glu Leu Lys Gly His Val Ile Ser Glu Ser 
                405                 410                 415     


Arg Ser Ile Asp Gly Leu Phe Met Asp Phe Ala Thr Gln Thr Tyr Asn 
            420                 425                 430         


Phe Glu Pro Glu Gln Phe Ser Ser Gly Thr Val Leu Ala Asp Leu Thr 
        435                 440                 445             


Ala Ala Thr Pro Gly Gly Leu His Val Glu Leu His Ser Glu Cys Val 
    450                 455                 460                 


Thr Arg Arg His Asn Lys Ser Ser Ser Ala Phe Thr Phe Thr Cys Asn 
465                 470                 475                 480 


Lys Phe Phe Arg Arg Asp Glu Phe Pro Leu His Phe Lys Asn Val His 
                485                 490                 495     


Thr Asp Ile Gln Ser Cys Leu Asn Gly Trp Phe Gln His Arg Cys Pro 
            500                 505                 510         


Leu Ala Tyr Leu Gly Cys Thr Phe Val Gln Asn His Phe Arg Pro Pro 
        515                 520                 525             


Gly Gln Lys Ala Lys Val Ile Tyr Ser Gln Glu Leu Lys Thr Phe Ala 
    530                 535                 540                 


Ile Lys Pro Glu Val Ala Pro Glu Leu Ser Glu Gly Arg Lys Asn Asn 
545                 550                 555                 560 


His Leu Leu Gly His Gly Gly Lys Ser Gln Asn Ser Leu Thr Ser Leu 
                565                 570                 575     


Pro Leu Glu Ile Leu Lys Tyr Ile Ala Gly Phe Leu Asp Ser Val Ser 
            580                 585                 590         


Leu Ala Gln Leu Ser Gln Val Ser Val Leu Met Arg Asn Ile Cys Ala 
        595                 600                 605             


Thr Leu Leu Gln Glu Arg Gly Met Val Leu Leu Gln Trp Lys Lys Lys 
    610                 615                 620                 


Arg Tyr Ser His Gly Gly Thr Ser Trp Arg Val His Arg Glu Ile Trp 
625                 630                 635                 640 


Gln Phe Ser Ser Leu Phe Ser Lys Ile Lys Ser Trp Glu Phe Asn Glu 
                645                 650                 655     


Val Thr Ser Met Ser Glu His Leu Lys Ser Cys Pro Phe Asn Ile Val 
            660                 665                 670         


Glu His Lys Thr Asp Pro Ile Leu Leu Thr Ser Met Cys Gln Pro Arg 
        675                 680                 685             


Glu Gln Ala Arg Glu Ser Leu Val Ser Thr Phe Arg Ile Arg Pro Arg 
    690                 695                 700                 


Gly Arg Tyr Val Ser 
705                 


<210>  3944
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO47__Homo_sapiens__XP_011523166

<400>  3944

Met Ala Ser Arg Ile Asn Thr Asn Phe Thr Leu Ile Pro Asn Gln Lys 
1               5                   10                  15      


Leu Arg Arg Ser Asn Arg Gln Thr Ser Cys Tyr Ser Lys Thr Leu Gly 
            20                  25                  30          


Ser Gly Phe Gln Pro Ile Ser Thr Phe Gly Asn Phe Lys Ala Leu Pro 
        35                  40                  45              


Leu Glu Ile Phe Gln Ile Ile Leu Lys Tyr Leu Ser Val Lys Asp Ile 
    50                  55                  60                  


Ser Met Leu Ser Met Val Ser Lys Thr Val Ser Gln His Ile Ile Asn 
65                  70                  75                  80  


Tyr Ile Ser Thr Ser Ser Gly Ser Lys Arg Leu Leu Leu Gln Asp Phe 
                85                  90                  95      


His Asn Leu Glu Leu Pro Asp Arg Arg Gln Asp Ser Ala Ile Leu Glu 
            100                 105                 110         


His Tyr Arg Ser Leu Gly Leu Leu Phe Lys Arg Cys Thr Leu Leu Leu 
        115                 120                 125             


Pro Thr Lys Glu Arg Leu Lys Tyr Ile His Lys Ile Leu Thr Glu Val 
    130                 135                 140                 


Ser Cys Phe Lys Phe Asn Gly Cys Ala Ala Pro Met Gln Cys Leu Gly 
145                 150                 155                 160 


Leu Thr Cys Tyr Gly Met Phe Leu Gln Thr Leu Thr Ala Gly Trp Asp 
                165                 170                 175     


Glu Leu Glu Cys His Arg Val Tyr Asn Phe Leu Cys Glu Leu Thr Asn 
            180                 185                 190         


Leu Cys Arg Lys Ile Gln Met Ala Val Cys Ser Lys Pro Gly Ser Ala 
        195                 200                 205             


Gln Lys Leu Glu Leu Arg Ile Arg Leu Phe Cys Arg Asn Val Leu Leu 
    210                 215                 220                 


Asp His Trp Thr His Arg Ser Asp Ser Ala Phe Trp Leu Thr Arg Ile 
225                 230                 235                 240 


Leu Lys Pro Trp Pro Met Val Asn Gln Ala Arg Leu Leu Tyr Ile Ile 
                245                 250                 255     


Phe Gly Pro Ile Ser Pro Gln Asp Gly Gln Val Val Trp Gln Glu Met 
            260                 265                 270         


Ile Glu Glu Pro Thr Asp Glu Phe Ser Leu Lys Gly Leu Ala Asp Ala 
        275                 280                 285             


Ile Lys Leu Leu Tyr Asp Ala Ser Thr Lys Glu Trp Thr Ala Asp Asp 
    290                 295                 300                 


Val Ile Ser Leu Val Asp Glu Leu Ser Val Val Pro Arg Glu Trp Leu 
305                 310                 315                 320 


Leu Glu Asn Asn Ala Arg Leu Leu Met Leu Ser Gly Asn Asn Ile Cys 
                325                 330                 335     


Phe Ser Phe Met Ala Ser Lys Ala Val Asn Gly Arg Thr Ile Glu Leu 
            340                 345                 350         


Ala Arg Leu Val Val Phe Leu Ala Leu Val Cys Glu Lys Glu Leu Tyr 
        355                 360                 365             


Cys Met Asp Trp Thr Val Lys Met Met Gln Lys Val Cys Lys Val Phe 
    370                 375                 380                 


Ser Thr Pro Val Glu Arg Lys Asn Phe Leu Gln Asn Val Ala Asn Ala 
385                 390                 395                 400 


Phe Ala Cys Val Ile Met Glu Met Leu Gln Ser Ile Met Ser Gly Asp 
                405                 410                 415     


Arg Asp Glu Asp Asp Arg Ser Phe Leu Asn Leu Phe His Leu Val His 
            420                 425                 430         


Ala Gln Ala Asn Phe His Lys Glu Val Leu Tyr Leu Thr Met Asn Thr 
        435                 440                 445             


Pro Leu Ser Thr 
    450         


<210>  3945
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO4__Homo_sapiens__NP_036308

<400>  3945

Met Ala Gly Ser Glu Pro Arg Ser Gly Thr Asn Ser Pro Pro Pro Pro 
1               5                   10                  15      


Phe Ser Asp Trp Gly Arg Leu Glu Ala Ala Ile Leu Ser Gly Trp Lys 
            20                  25                  30          


Thr Phe Trp Gln Ser Val Ser Lys Glu Arg Val Ala Arg Thr Thr Ser 
        35                  40                  45              


Arg Glu Glu Val Asp Glu Ala Ala Ser Thr Leu Thr Arg Leu Pro Ile 
    50                  55                  60                  


Asp Val Gln Leu Tyr Ile Leu Ser Phe Leu Ser Pro His Asp Leu Cys 
65                  70                  75                  80  


Gln Leu Gly Ser Thr Asn His Tyr Trp Asn Glu Thr Val Arg Asp Pro 
                85                  90                  95      


Ile Leu Trp Arg Tyr Phe Leu Leu Arg Asp Leu Pro Ser Trp Ser Ser 
            100                 105                 110         


Val Asp Trp Lys Ser Leu Pro Asp Leu Glu Ile Leu Lys Lys Pro Ile 
        115                 120                 125             


Ser Glu Val Thr Asp Gly Ala Phe Phe Asp Tyr Met Ala Val Tyr Arg 
    130                 135                 140                 


Met Cys Cys Pro Tyr Thr Arg Arg Ala Ser Lys Ser Ser Arg Pro Met 
145                 150                 155                 160 


Tyr Gly Ala Val Thr Ser Phe Leu His Ser Leu Ile Ile Gln Asn Glu 
                165                 170                 175     


Pro Arg Phe Ala Met Phe Gly Pro Gly Leu Glu Glu Leu Asn Thr Ser 
            180                 185                 190         


Leu Val Leu Ser Leu Met Ser Ser Glu Glu Leu Cys Pro Thr Ala Gly 
        195                 200                 205             


Leu Pro Gln Arg Gln Ile Asp Gly Ile Gly Ser Gly Val Asn Phe Gln 
    210                 215                 220                 


Leu Asn Asn Gln His Lys Phe Asn Ile Leu Ile Leu Tyr Ser Thr Thr 
225                 230                 235                 240 


Arg Lys Glu Arg Asp Arg Ala Arg Glu Glu His Thr Ser Ala Val Asn 
                245                 250                 255     


Lys Met Phe Ser Arg His Asn Glu Gly Asp Asp Gln Gln Gly Ser Arg 
            260                 265                 270         


Tyr Ser Val Ile Pro Gln Ile Gln Lys Val Cys Glu Val Val Asp Gly 
        275                 280                 285             


Phe Ile Tyr Val Ala Asn Ala Glu Ala His Lys Arg His Glu Trp Gln 
    290                 295                 300                 


Asp Glu Phe Ser His Ile Met Ala Met Thr Asp Pro Ala Phe Gly Ser 
305                 310                 315                 320 


Ser Gly Arg Pro Leu Leu Val Leu Ser Cys Ile Ser Gln Gly Asp Val 
                325                 330                 335     


Lys Arg Met Pro Cys Phe Tyr Leu Ala His Glu Leu His Leu Asn Leu 
            340                 345                 350         


Leu Asn His Pro Trp Leu Val Gln Asp Thr Glu Ala Glu Thr Leu Thr 
        355                 360                 365             


Gly Phe Leu Asn Gly Ile Glu Trp Ile Leu Glu Glu Val Glu Ser Lys 
    370                 375                 380                 


Arg Ala Arg 
385         


<210>  3946
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO5__Homo_sapiens__NP_001135994

<400>  3946

Met Lys Cys Asp Phe Asn Cys Asn His Val His Ser Gly Leu Lys Leu 
1               5                   10                  15      


Val Lys Pro Asp Asp Ile Gly Arg Leu Val Ser Tyr Thr Pro Ala Tyr 
            20                  25                  30          


Leu Glu Gly Ser Cys Lys Asp Cys Ile Lys Asp Tyr Glu Arg Leu Ser 
        35                  40                  45              


Cys Ile Gly Ser Pro Ile Val Ser Pro Arg Ile Val Gln Leu Glu Thr 
    50                  55                  60                  


Glu Ser Lys Arg Leu His Asn Lys Glu Asn Gln His Val Gln Gln Thr 
65                  70                  75                  80  


Leu Asn Ser Thr Asn Glu Ile Glu Ala Leu Glu Thr Ser Arg Leu Tyr 
                85                  90                  95      


Glu Asp Ser Gly Tyr Ser Ser Phe Ser Leu Gln Ser Gly Leu Ser Glu 
            100                 105                 110         


His Glu Glu Gly Ser Leu Leu Glu Glu Asn Phe Gly Asp Ser Leu Gln 
        115                 120                 125             


Ser Cys Leu Leu Gln Ile Gln Ser Pro Asp Gln Tyr Pro Asn Lys Asn 
    130                 135                 140                 


Leu Leu Pro Val Leu His Phe Glu Lys Val Val Cys Ser Thr Leu Lys 
145                 150                 155                 160 


Lys Asn Ala Lys Arg Asn Pro Lys Val Asp Arg Glu Met Leu Lys Glu 
                165                 170                 175     


Ile Ile Ala Arg Gly Asn Phe Arg Leu Gln Asn Ile Ile Gly Arg Lys 
            180                 185                 190         


Met Gly Leu Glu Cys Val Asp Ile Leu Ser Glu Leu Phe Arg Arg Gly 
        195                 200                 205             


Leu Arg His Val Leu Ala Thr Ile Leu Ala Gln Leu Ser Asp Met Asp 
    210                 215                 220                 


Leu Ile Asn Val Ser Lys Val Ser Thr Thr Trp Lys Lys Ile Leu Glu 
225                 230                 235                 240 


Asp Asp Lys Gly Ala Phe Gln Leu Tyr Ser Lys Ala Ile Gln Arg Val 
                245                 250                 255     


Thr Glu Asn Asn Asn Lys Phe Ser Pro His Ala Ser Thr Arg Glu Tyr 
            260                 265                 270         


Val Met Phe Arg Thr Pro Leu Ala Ser Val Gln Lys Ser Ala Ala Gln 
        275                 280                 285             


Thr Ser Leu Lys Lys Asp Ala Gln Thr Lys Leu Ser Asn Gln Gly Asp 
    290                 295                 300                 


Gln Lys Gly Ser Thr Tyr Ser Arg His Asn Glu Phe Ser Glu Val Ala 
305                 310                 315                 320 


Lys Thr Leu Lys Lys Asn Glu Ser Leu Lys Ala Cys Ile Arg Cys Asn 
                325                 330                 335     


Ser Pro Ala Lys Tyr Asp Cys Tyr Leu Gln Arg Ala Thr Cys Lys Arg 
            340                 345                 350         


Glu Gly Cys Gly Phe Asp Tyr Cys Thr Lys Cys Leu Cys Asn Tyr His 
        355                 360                 365             


Thr Thr Lys Asp Cys Ser Asp Gly Lys Leu Leu Lys Ala Ser Cys Lys 
    370                 375                 380                 


Ile Gly Pro Leu Pro Gly Thr Lys Lys Ser Lys Lys Asn Leu Arg Arg 
385                 390                 395                 400 


Leu 
    


<210>  3947
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO7__Homo_sapiens__NP_001028196

<400>  3947

Met Ala Arg Pro Pro Gly Gly Ser Gly Pro Leu Leu Asp Ser Glu His 
1               5                   10                  15      


Ser Ser Leu Gln Asn Asn Glu Gln Pro Ser Leu Ala Thr Ser Ser Asn 
            20                  25                  30          


Gln Thr Ser Met Gln Asp Glu Gln Pro Ser Asp Ser Phe Gln Gly Gln 
        35                  40                  45              


Ala Ala Gln Ser Gly Val Trp Asn Asp Asp Ser Met Leu Gly Pro Ser 
    50                  55                  60                  


Gln Asn Phe Glu Ala Glu Ser Ile Gln Asp Asn Ala His Met Ala Glu 
65                  70                  75                  80  


Gly Thr Gly Phe Tyr Pro Ser Glu Pro Met Leu Cys Ser Glu Ser Val 
                85                  90                  95      


Glu Gly Gln Val Pro His Ser Leu Glu Thr Leu Tyr Gln Ser Ala Asp 
            100                 105                 110         


Cys Ser Asp Ala Asn Asp Ala Leu Ile Val Leu Ile His Leu Leu Met 
        115                 120                 125             


Leu Glu Ser Gly Tyr Ile Pro Gln Gly Thr Glu Ala Lys Ala Leu Ser 
    130                 135                 140                 


Met Pro Glu Lys Trp Lys Leu Ser Gly Val Tyr Lys Leu Gln Tyr Met 
145                 150                 155                 160 


His Pro Leu Cys Glu Gly Ser Ser Ala Thr Leu Thr Cys Val Pro Leu 
                165                 170                 175     


Gly Asn Leu Ile Val Val Asn Ala Thr Leu Lys Ile Asn Asn Glu Ile 
            180                 185                 190         


Arg Ser Val Lys Arg Leu Gln Leu Leu Pro Glu Ser Phe Ile Cys Lys 
        195                 200                 205             


Glu Lys Leu Gly Glu Asn Val Ala Asn Ile Tyr Lys Asp Leu Gln Lys 
    210                 215                 220                 


Leu Ser Arg Leu Phe Lys Asp Gln Leu Val Tyr Pro Leu Leu Ala Phe 
225                 230                 235                 240 


Thr Arg Gln Ala Leu Asn Leu Pro Asp Val Phe Gly Leu Val Val Leu 
                245                 250                 255     


Pro Leu Glu Leu Lys Leu Arg Ile Phe Arg Leu Leu Asp Val Arg Ser 
            260                 265                 270         


Val Leu Ser Leu Ser Ala Val Cys Arg Asp Leu Phe Thr Ala Ser Asn 
        275                 280                 285             


Asp Pro Leu Leu Trp Arg Phe Leu Tyr Leu Arg Asp Phe Arg Asp Asn 
    290                 295                 300                 


Thr Val Arg Val Gln Asp Thr Asp Trp Lys Glu Leu Tyr Arg Lys Arg 
305                 310                 315                 320 


His Ile Gln Arg Lys Glu Ser Pro Lys Gly Arg Phe Val Met Leu Leu 
                325                 330                 335     


Pro Ser Ser Thr His Thr Ile Pro Phe Tyr Pro Asn Pro Leu His Pro 
            340                 345                 350         


Arg Pro Phe Pro Ser Ser Arg Leu Pro Pro Gly Ile Ile Gly Gly Glu 
        355                 360                 365             


Tyr Asp Gln Arg Pro Thr Leu Pro Tyr Val Gly Asp Pro Ile Ser Ser 
    370                 375                 380                 


Leu Ile Pro Gly Pro Gly Glu Thr Pro Ser Gln Phe Pro Pro Leu Arg 
385                 390                 395                 400 


Pro Arg Phe Asp Pro Val Gly Pro Leu Pro Gly Pro Asn Pro Ile Leu 
                405                 410                 415     


Pro Gly Arg Gly Gly Pro Asn Asp Arg Phe Pro Phe Arg Pro Ser Arg 
            420                 425                 430         


Gly Arg Pro Thr Asp Gly Arg Leu Ser Phe Met 
        435                 440             


<210>  3948
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO8__Homo_sapiens__NP_036312

<400>  3948

Met Gly Gln Gly Leu Trp Arg Val Val Arg Asn Gln Gln Leu Gln Gln 
1               5                   10                  15      


Glu Gly Tyr Ser Glu Gln Gly Tyr Leu Thr Arg Glu Gln Ser Arg Arg 
            20                  25                  30          


Met Ala Ala Ser Asn Ile Ser Asn Thr Asn His Arg Lys Gln Val Gln 
        35                  40                  45              


Gly Gly Ile Asp Ile Tyr His Leu Leu Lys Ala Arg Lys Ser Lys Glu 
    50                  55                  60                  


Gln Glu Gly Phe Ile Asn Leu Glu Met Leu Pro Pro Glu Leu Ser Phe 
65                  70                  75                  80  


Thr Ile Leu Ser Tyr Leu Asn Ala Thr Asp Leu Cys Leu Ala Ser Cys 
                85                  90                  95      


Val Trp Gln Asp Leu Ala Asn Asp Glu Leu Leu Trp Gln Gly Leu Cys 
            100                 105                 110         


Lys Ser Thr Trp Gly His Cys Ser Ile Tyr Asn Lys Asn Pro Pro Leu 
        115                 120                 125             


Gly Phe Ser Phe Arg Lys Leu Tyr Met Gln Leu Asp Glu Gly Ser Leu 
    130                 135                 140                 


Thr Phe Asn Ala Asn Pro Asp Glu Gly Val Asn Tyr Phe Met Ser Lys 
145                 150                 155                 160 


Gly Ile Leu Asp Asp Ser Pro Lys Glu Ile Ala Lys Phe Ile Phe Cys 
                165                 170                 175     


Thr Arg Thr Leu Asn Trp Lys Lys Leu Arg Ile Tyr Leu Asp Glu Arg 
            180                 185                 190         


Arg Asp Val Leu Asp Asp Leu Val Thr Leu His Asn Phe Arg Asn Gln 
        195                 200                 205             


Phe Leu Pro Asn Ala Leu Arg Glu Phe Phe Arg His Ile His Ala Pro 
    210                 215                 220                 


Glu Glu Arg Gly Glu Tyr Leu Glu Thr Leu Ile Thr Lys Phe Ser His 
225                 230                 235                 240 


Arg Phe Cys Ala Cys Asn Pro Asp Leu Met Arg Glu Leu Gly Leu Ser 
                245                 250                 255     


Pro Asp Ala Val Tyr Val Leu Cys Tyr Ser Leu Ile Leu Leu Ser Ile 
            260                 265                 270         


Asp Leu Thr Ser Pro His Val Lys Asn Lys Met Ser Lys Arg Glu Phe 
        275                 280                 285             


Ile Arg Asn Thr Arg Arg Ala Ala Gln Asn Ile Ser Glu Asp Phe Val 
    290                 295                 300                 


Gly His Leu Tyr Asp Asn Ile Tyr Leu Ile Gly His Val Ala Ala 
305                 310                 315                 


<210>  3949
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXO9__Homo_sapiens__NP_036479

<400>  3949

Met Pro Asp Ile Ile Trp Val Phe Pro Pro Gln Ala Glu Ala Glu Glu 
1               5                   10                  15      


Asp Cys His Ser Asp Thr Val Arg Ala Asp Asp Asp Glu Glu Asn Glu 
            20                  25                  30          


Ser Pro Ala Glu Thr Asp Leu Gln Ala Gln Leu Gln Met Phe Arg Ala 
        35                  40                  45              


Gln Trp Met Phe Glu Leu Ala Pro Gly Val Ser Ser Ser Asn Leu Glu 
    50                  55                  60                  


Asn Arg Pro Cys Arg Ala Ala Arg Gly Ser Leu Gln Lys Thr Ser Ala 
65                  70                  75                  80  


Asp Thr Lys Gly Lys Gln Glu Gln Ala Lys Glu Glu Lys Ala Arg Glu 
                85                  90                  95      


Leu Phe Leu Lys Ala Val Glu Glu Glu Gln Asn Gly Ala Leu Tyr Glu 
            100                 105                 110         


Ala Ile Lys Phe Tyr Arg Arg Ala Met Gln Leu Val Pro Asp Ile Glu 
        115                 120                 125             


Phe Lys Ile Thr Tyr Thr Arg Ser Pro Asp Gly Asp Gly Val Gly Asn 
    130                 135                 140                 


Ser Tyr Ile Glu Asp Asn Asp Asp Asp Ser Lys Met Ala Asp Leu Leu 
145                 150                 155                 160 


Ser Tyr Phe Gln Gln Gln Leu Thr Phe Gln Glu Ser Val Leu Lys Leu 
                165                 170                 175     


Cys Gln Pro Glu Leu Glu Ser Ser Gln Ile His Ile Ser Val Leu Pro 
            180                 185                 190         


Met Glu Val Leu Met Tyr Ile Phe Arg Trp Val Val Ser Ser Asp Leu 
        195                 200                 205             


Asp Leu Arg Ser Leu Glu Gln Leu Ser Leu Val Cys Arg Gly Phe Tyr 
    210                 215                 220                 


Ile Cys Ala Arg Asp Pro Glu Ile Trp Arg Leu Ala Cys Leu Lys Val 
225                 230                 235                 240 


Trp Gly Arg Ser Cys Ile Lys Leu Val Pro Tyr Thr Ser Trp Arg Glu 
                245                 250                 255     


Met Phe Leu Glu Arg Pro Arg Val Arg Phe Asp Gly Val Tyr Ile Ser 
            260                 265                 270         


Lys Thr Thr Tyr Ile Arg Gln Gly Glu Gln Ser Leu Asp Gly Phe Tyr 
        275                 280                 285             


Arg Ala Trp His Gln Val Glu Tyr Tyr Arg Tyr Ile Arg Phe Phe Pro 
    290                 295                 300                 


Asp Gly His Val Met Met Leu Thr Thr Pro Glu Glu Pro Gln Ser Ile 
305                 310                 315                 320 


Val Pro Arg Leu Arg Thr Arg Asn Thr Arg Thr Asp Ala Ile Leu Leu 
                325                 330                 335     


Gly His Tyr Arg Leu Ser Gln Asp Thr Asp Asn Gln Thr Lys Val Phe 
            340                 345                 350         


Ala Val Ile Thr Lys Lys Lys Glu Glu Lys Pro Leu Asp Tyr Lys Tyr 
        355                 360                 365             


Arg Tyr Phe Arg Arg Val Pro Val Gln Glu Ala Asp Gln Ser Phe His 
    370                 375                 380                 


Val Gly Leu Gln Leu Cys Ser Ser Gly His Gln Arg Phe Asn Lys Leu 
385                 390                 395                 400 


Ile Trp Ile His His Ser Cys His Ile Thr Tyr Lys Ser Thr Gly Glu 
                405                 410                 415     


Thr Ala Val Ser Ala Phe Glu Ile Asp Lys Met Tyr Thr Pro Leu Phe 
            420                 425                 430         


Phe Ala Arg Val Arg Ser Tyr Thr Ala Phe Ser Glu Arg Pro Leu 
        435                 440                 445         


<210>  3950
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXW11__Homo_sapiens__NP_036432

<400>  3950

Met Glu Pro Asp Ser Val Ile Glu Asp Lys Thr Ile Glu Leu Met Cys 
1               5                   10                  15      


Ser Val Pro Arg Ser Leu Trp Leu Gly Cys Ala Asn Leu Val Glu Ser 
            20                  25                  30          


Met Cys Ala Leu Ser Cys Leu Gln Ser Met Pro Ser Val Arg Cys Leu 
        35                  40                  45              


Gln Ile Ser Asn Gly Thr Ser Ser Val Ile Val Ser Arg Lys Arg Pro 
    50                  55                  60                  


Ser Glu Gly Asn Tyr Gln Lys Glu Lys Asp Leu Cys Ile Lys Tyr Phe 
65                  70                  75                  80  


Asp Gln Trp Ser Glu Ser Asp Gln Val Glu Phe Val Glu His Leu Ile 
                85                  90                  95      


Ser Arg Met Cys His Tyr Gln His Gly His Ile Asn Ser Tyr Leu Lys 
            100                 105                 110         


Pro Met Leu Gln Arg Asp Phe Ile Thr Ala Leu Pro Glu Gln Gly Leu 
        115                 120                 125             


Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala Arg Ser Leu 
    130                 135                 140                 


Cys Ala Ala Glu Leu Val Cys Lys Glu Trp Gln Arg Val Ile Ser Glu 
145                 150                 155                 160 


Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Met Val Arg Thr Asp Pro 
                165                 170                 175     


Leu Trp Lys Gly Leu Ser Glu Arg Arg Gly Trp Asp Gln Tyr Leu Phe 
            180                 185                 190         


Lys Asn Arg Pro Thr Asp Gly Pro Pro Asn Ser Phe Tyr Arg Ser Leu 
        195                 200                 205             


Tyr Pro Lys Ile Ile Gln Asp Ile Glu Thr Ile Glu Ser Asn Trp Arg 
    210                 215                 220                 


Cys Gly Arg His Asn Leu Gln Arg Ile Gln Cys Arg Ser Glu Asn Ser 
225                 230                 235                 240 


Lys Gly Val Tyr Cys Leu Gln Tyr Asp Asp Glu Lys Ile Ile Ser Gly 
                245                 250                 255     


Leu Arg Asp Asn Ser Ile Lys Ile Trp Asp Lys Thr Ser Leu Glu Cys 
            260                 265                 270         


Leu Lys Val Leu Thr Gly His Thr Gly Ser Val Leu Cys Leu Gln Tyr 
        275                 280                 285             


Asp Glu Arg Val Ile Val Thr Gly Ser Ser Asp Ser Thr Val Arg Val 
    290                 295                 300                 


Trp Asp Val Asn Thr Gly Glu Val Leu Asn Thr Leu Ile His His Asn 
305                 310                 315                 320 


Glu Ala Val Leu His Leu Arg Phe Ser Asn Gly Leu Met Val Thr Cys 
                325                 330                 335     


Ser Lys Asp Arg Ser Ile Ala Val Trp Asp Met Ala Ser Ala Thr Asp 
            340                 345                 350         


Ile Thr Leu Arg Arg Val Leu Val Gly His Arg Ala Ala Val Asn Val 
        355                 360                 365             


Val Asp Phe Asp Asp Lys Tyr Ile Val Ser Ala Ser Gly Asp Arg Thr 
    370                 375                 380                 


Ile Lys Val Trp Ser Thr Ser Thr Cys Glu Phe Val Arg Thr Leu Asn 
385                 390                 395                 400 


Gly His Lys Arg Gly Ile Ala Cys Leu Gln Tyr Arg Asp Arg Leu Val 
                405                 410                 415     


Val Ser Gly Ser Ser Asp Asn Thr Ile Arg Leu Trp Asp Ile Glu Cys 
            420                 425                 430         


Gly Ala Cys Leu Arg Val Leu Glu Gly His Glu Glu Leu Val Arg Cys 
        435                 440                 445             


Ile Arg Phe Asp Asn Lys Arg Ile Val Ser Gly Ala Tyr Asp Gly Lys 
    450                 455                 460                 


Ile Lys Val Trp Asp Leu Gln Ala Ala Leu Asp Pro Arg Ala Pro Ala 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Arg Thr Leu Val Glu His Ser Gly Arg Val Phe 
                485                 490                 495     


Arg Leu Gln Phe Asp Glu Phe Gln Ile Ile Ser Ser Ser His Asp Asp 
            500                 505                 510         


Thr Ile Leu Ile Trp Asp Phe Leu Asn Val Pro Pro Ser Ala Gln Asn 
        515                 520                 525             


Glu Thr Arg Ser Pro Ser Arg Thr Tyr Thr Tyr Ile Ser Arg 
    530                 535                 540         


<210>  3951
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXW4__Homo_sapiens__NP_071322

<400>  3951

Met Ala Ala Ala Ala Gly Glu Glu Glu Glu Glu Glu Glu Ala Ala Arg 
1               5                   10                  15      


Glu Ser Ala Ala Arg Pro Ala Ala Gly Pro Ala Leu Trp Arg Leu Pro 
            20                  25                  30          


Glu Glu Leu Leu Leu Leu Ile Cys Ser Tyr Leu Asp Met Arg Ala Leu 
        35                  40                  45              


Gly Arg Leu Ala Gln Val Cys Arg Trp Leu Arg Arg Phe Thr Ser Cys 
    50                  55                  60                  


Asp Leu Leu Trp Arg Arg Ile Ala Arg Ala Ser Leu Asn Ser Gly Phe 
65                  70                  75                  80  


Thr Arg Leu Gly Thr Asp Leu Met Thr Ser Val Pro Val Lys Glu Arg 
                85                  90                  95      


Val Lys Val Ser Gln Asn Trp Arg Leu Gly Arg Cys Arg Glu Gly Ile 
            100                 105                 110         


Leu Leu Lys Trp Arg Cys Ser Gln Met Pro Trp Met Gln Leu Glu Asp 
        115                 120                 125             


Asp Ser Leu Tyr Ile Ser Gln Ala Asn Phe Ile Leu Ala Tyr Gln Phe 
    130                 135                 140                 


Arg Pro Asp Gly Ala Ser Leu Asn Arg Arg Pro Leu Gly Val Phe Ala 
145                 150                 155                 160 


Gly His Asp Glu Asp Val Cys His Phe Val Leu Ala Asn Ser His Ile 
                165                 170                 175     


Val Ser Ala Gly Gly Asp Gly Lys Ile Gly Ile His Lys Ile His Ser 
            180                 185                 190         


Thr Phe Thr Val Lys Tyr Ser Ala His Glu Gln Glu Val Asn Cys Val 
        195                 200                 205             


Asp Cys Lys Gly Gly Ile Ile Val Ser Gly Ser Arg Asp Arg Thr Ala 
    210                 215                 220                 


Lys Val Trp Pro Leu Ala Ser Gly Arg Leu Gly Gln Cys Leu His Thr 
225                 230                 235                 240 


Ile Gln Thr Glu Asp Arg Val Trp Ser Ile Ala Ile Ser Pro Leu Leu 
                245                 250                 255     


Ser Ser Phe Val Thr Gly Thr Ala Cys Cys Gly His Phe Ser Pro Leu 
            260                 265                 270         


Arg Ile Trp Asp Leu Asn Ser Gly Gln Leu Met Thr His Leu Gly Ser 
        275                 280                 285             


Asp Phe Pro Pro Gly Ala Gly Val Leu Asp Val Met Tyr Glu Ser Pro 
    290                 295                 300                 


Phe Thr Leu Leu Ser Cys Gly Tyr Asp Thr Tyr Val Arg Tyr Trp Asp 
305                 310                 315                 320 


Leu Arg Thr Ser Val Arg Lys Cys Val Met Glu Trp Glu Glu Pro His 
                325                 330                 335     


Asp Ser Thr Leu Tyr Cys Leu Gln Thr Asp Gly Asn His Leu Leu Ala 
            340                 345                 350         


Thr Gly Ser Ser Tyr Tyr Gly Val Val Arg Leu Trp Asp Arg Arg Gln 
        355                 360                 365             


Arg Ala Cys Leu His Ala Phe Pro Leu Thr Ser Thr Pro Leu Ser Ser 
    370                 375                 380                 


Pro Val Tyr Cys Leu Arg Leu Thr Thr Lys His Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Ser Tyr Asn Leu His Val Leu Asp Phe Gln Asn Pro 
                405                 410         


<210>  3952
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXW7__Homo_sapiens__NP_060785

<400>  3952

Met Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr 
1               5                   10                  15      


Cys Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr 
            20                  25                  30          


Cys Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys 
        35                  40                  45              


Gly Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr 
    50                  55                  60                  


Glu Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr 
65                  70                  75                  80  


Leu Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                85                  90                  95      


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            100                 105                 110         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        115                 120                 125             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    130                 135                 140                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
145                 150                 155                 160 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                165                 170                 175     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            180                 185                 190         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        195                 200                 205             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    210                 215                 220                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
225                 230                 235                 240 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                245                 250                 255     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            260                 265                 270         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        275                 280                 285             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    290                 295                 300                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
305                 310                 315                 320 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                325                 330                 335     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            340                 345                 350         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        355                 360                 365             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    370                 375                 380                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
385                 390                 395                 400 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                405                 410                 415     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            420                 425                 430         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        435                 440                 445             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    450                 455                 460                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
465                 470                 475                 480 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                485                 490                 495     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            500                 505                 510         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        515                 520                 525             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    530                 535                 540                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
545                 550                 555                 560 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                565                 570                 575     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            580                 585                 590         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        595                 600                 605             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    610                 615                 620                 


Asp Met Lys 
625         


<210>  3953
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBXW8__Homo_sapiens__NP_036306

<400>  3953

Met Asp Asp Tyr Ser Leu Asp Glu Phe Arg Arg Arg Trp Gln Glu Glu 
1               5                   10                  15      


Leu Ala Gln Ala Gln Ala Pro Lys Lys Arg Arg Arg Pro Glu Ala Ala 
            20                  25                  30          


Glu Arg Arg Ala Arg Arg Pro Glu Asn Glu Met Asn Asp Val Pro Phe 
        35                  40                  45              


Phe Asp Ile Gln Leu Pro Tyr Glu Leu Ala Ile Asn Ile Phe Gln Tyr 
    50                  55                  60                  


Leu Asp Arg Lys Glu Leu Gly Arg Cys Ala Gln Val Ser Lys Thr Trp 
65                  70                  75                  80  


Lys Val Ile Ala Glu Asp Glu Val Leu Trp Tyr Arg Leu Cys Gln Gln 
                85                  90                  95      


Glu Gly His Leu Pro Asp Ser Ser Ile Ser Asp Tyr Ser Cys Trp Lys 
            100                 105                 110         


Leu Ile Phe Gln Glu Cys Arg Ala Lys Glu His Met Leu Arg Thr Asn 
        115                 120                 125             


Trp Lys Asn Arg Lys Gly Ala Val Ser Glu Leu Glu His Val Pro Asp 
    130                 135                 140                 


Thr Val Leu Cys Asp Val His Ser His Asp Gly Val Val Ile Ala Gly 
145                 150                 155                 160 


Tyr Thr Ser Gly Asp Val Arg Val Trp Asp Thr Arg Thr Trp Asp Tyr 
                165                 170                 175     


Val Ala Pro Phe Leu Glu Ser Glu Asp Glu Glu Asp Glu Pro Gly Met 
            180                 185                 190         


Gln Pro Asn Val Ser Phe Val Arg Ile Asn Ser Ser Leu Ala Val Ala 
        195                 200                 205             


Ala Tyr Glu Asp Gly Phe Leu Asn Ile Trp Asp Leu Arg Thr Gly Lys 
    210                 215                 220                 


Tyr Pro Val His Arg Phe Glu His Asp Ala Arg Ile Gln Ala Leu Ala 
225                 230                 235                 240 


Leu Ser Gln Asp Asp Ala Thr Val Ala Thr Ala Ser Ala Phe Asp Val 
                245                 250                 255     


Val Met Leu Ser Pro Asn Glu Glu Gly Tyr Trp Gln Ile Ala Ala Glu 
            260                 265                 270         


Phe Glu Val Pro Lys Leu Val Gln Tyr Leu Glu Ile Val Pro Glu Thr 
        275                 280                 285             


Arg Arg Tyr Pro Val Ala Val Ala Ala Ala Gly Asp Leu Met Tyr Leu 
    290                 295                 300                 


Leu Lys Ala Glu Asp Ser Ala Arg Thr Leu Leu Tyr Ala His Gly Pro 
305                 310                 315                 320 


Pro Val Thr Cys Leu Asp Val Ser Ala Asn Gln Val Ala Phe Gly Val 
                325                 330                 335     


Gln Gly Leu Gly Trp Val Tyr Glu Gly Ser Lys Ile Leu Val Tyr Ser 
            340                 345                 350         


Leu Glu Ala Gly Arg Arg Leu Leu Lys Leu Gly Asn Val Leu Arg Asp 
        355                 360                 365             


Phe Thr Cys Val Asn Leu Ser Asp Ser Pro Pro Asn Leu Met Val Ser 
    370                 375                 380                 


Gly Asn Met Asp Gly Arg Val Arg Ile His Asp Leu Arg Ser Gly Asn 
385                 390                 395                 400 


Ile Ala Leu Ser Leu Ser Ala His Gln Leu Arg Val Ser Ala Val Gln 
                405                 410                 415     


Met Asp Asp Trp Lys Ile Val Ser Gly Gly Glu Glu Gly Leu Val Ser 
            420                 425                 430         


Val Trp Asp Tyr Arg Met Asn Gln Lys Leu Trp Glu Val Tyr Ser Gly 
        435                 440                 445             


His Pro Val Gln His Ile Ser Phe Ser Ser His Ser Leu Ile Thr Ala 
    450                 455                 460                 


Asn Val Pro Tyr Gln Thr Val Met Arg Asn Ala Asp Leu Asp Ser Phe 
465                 470                 475                 480 


Thr Thr His Arg Arg His Arg Gly Leu Ile Arg Ala Tyr Glu Phe Ala 
                485                 490                 495     


Val Asp Gln Leu Ala Phe Gln Ser Pro Leu Pro Val Cys Arg Ser Ser 
            500                 505                 510         


Cys Asp Ala Met Ala Thr His Tyr Tyr Asp Leu Ala Leu Ala Phe Pro 
        515                 520                 525             


Tyr Asn His Val 
    530         


<210>  3954
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCAR__Homo_sapiens__NP_001991

<400>  3954

Met Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 
1               5                   10                  15      


Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser 
            20                  25                  30          


Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys Ile Gln 
        35                  40                  45              


Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu Met Ile Ile Lys 
    50                  55                  60                  


Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg Leu Lys Phe Trp Asn Glu 
65                  70                  75                  80  


Thr Asp Pro Glu Phe Val Ile Asp His Met Asp Ala Asn Lys Ala Gly 
                85                  90                  95      


Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 
            100                 105                 110         


Asp Thr Leu Glu Leu Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu 
        115                 120                 125             


Ser Ala Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu 
    130                 135                 140                 


Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys 
145                 150                 155                 160 


Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu His Pro Ala 
                165                 170                 175     


Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser Gly Ile Tyr Arg 
            180                 185                 190         


Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr Leu Trp Ser Phe Pro Ser 
        195                 200                 205             


Asn Ala Leu Glu Leu Val Val Thr Asp Ser Ile His Gln Asp Tyr Thr 
    210                 215                 220                 


Thr Gln Asn Leu Ile Arg Met Ala Val Ala Gly Leu Val Leu Val Ala 
225                 230                 235                 240 


Leu Leu Ala Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn 
                245                 250                 255     


Lys Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met 
            260                 265                 270         


Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 
        275                 280                 285         


<210>  3955
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCER1A__Homo_sapiens__NP_001992

<400>  3955

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  3956
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCER1G__Homo_sapiens__NP_004097

<400>  3956

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  3957
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCER2__Homo_sapiens__NP_001193948

<400>  3957

Met Asn Pro Pro Ser Gln Glu Ile Glu Glu Leu Pro Arg Arg Arg Cys 
1               5                   10                  15      


Cys Arg Arg Gly Thr Gln Ile Val Leu Leu Gly Leu Val Thr Ala Ala 
            20                  25                  30          


Leu Trp Ala Gly Leu Leu Thr Leu Leu Leu Leu Trp His Trp Asp Thr 
        35                  40                  45              


Thr Gln Ser Leu Lys Gln Leu Glu Glu Arg Ala Ala Arg Asn Val Ser 
    50                  55                  60                  


Gln Val Ser Lys Asn Leu Glu Ser His His Gly Asp Gln Met Ala Gln 
65                  70                  75                  80  


Lys Ser Gln Ser Thr Gln Ile Ser Gln Glu Leu Glu Glu Leu Arg Ala 
                85                  90                  95      


Glu Gln Gln Arg Leu Lys Ser Gln Asp Leu Glu Leu Ser Trp Asn Leu 
            100                 105                 110         


Asn Gly Leu Gln Ala Asp Leu Ser Ser Phe Lys Ser Gln Glu Leu Asn 
        115                 120                 125             


Glu Arg Asn Glu Ala Ser Asp Leu Leu Glu Arg Leu Arg Glu Glu Val 
    130                 135                 140                 


Thr Lys Leu Arg Met Glu Leu Gln Val Ser Ser Gly Phe Val Cys Asn 
145                 150                 155                 160 


Thr Cys Pro Glu Lys Trp Ile Asn Phe Gln Arg Lys Cys Tyr Tyr Phe 
                165                 170                 175     


Gly Lys Gly Thr Lys Gln Trp Val His Ala Arg Tyr Ala Cys Asp Asp 
            180                 185                 190         


Met Glu Gly Gln Leu Val Ser Ile His Ser Pro Glu Glu Gln Asp Phe 
        195                 200                 205             


Leu Thr Lys His Ala Ser His Thr Gly Ser Trp Ile Gly Leu Arg Asn 
    210                 215                 220                 


Leu Asp Leu Lys Gly Glu Phe Ile Trp Val Asp Gly Ser His Val Asp 
225                 230                 235                 240 


Tyr Ser Asn Trp Ala Pro Gly Glu Pro Thr Ser Arg Ser Gln Gly Glu 
                245                 250                 255     


Asp Cys Val Met Met Arg Gly Ser Gly Arg Trp Asn Asp Ala Phe Cys 
            260                 265                 270         


Asp Arg Lys Leu Gly Ala Trp Val Cys Asp Arg Leu Ala Thr Cys Thr 
        275                 280                 285             


Pro Pro Ala Ser Glu Gly Ser Ala Glu Ser Met Gly Pro Asp Ser Arg 
    290                 295                 300                 


Pro Asp Pro Asp Gly Arg Leu Pro Thr Pro Ser Ala Pro Leu His Ser 
305                 310                 315                 320 


<210>  3958
<211>  5405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCGBP__Homo_sapiens__NP_003881

<400>  3958

Met Gly Ala Leu Trp Ser Trp Trp Ile Leu Trp Ala Gly Ala Thr Leu 
1               5                   10                  15      


Leu Trp Gly Leu Thr Gln Glu Ala Ser Val Asp Leu Lys Asn Thr Gly 
            20                  25                  30          


Arg Glu Glu Phe Leu Thr Ala Phe Leu Gln Asn Tyr Gln Leu Ala Tyr 
        35                  40                  45              


Ser Lys Ala Tyr Pro Arg Leu Leu Ile Ser Ser Leu Ser Glu Ser Pro 
    50                  55                  60                  


Ala Ser Val Ser Ile Leu Ser Gln Ala Asp Asn Thr Ser Lys Lys Val 
65                  70                  75                  80  


Thr Val Arg Pro Gly Glu Ser Val Met Val Asn Ile Ser Ala Lys Ala 
                85                  90                  95      


Glu Met Ile Gly Ser Lys Ile Phe Gln His Ala Val Val Ile His Ser 
            100                 105                 110         


Asp Tyr Ala Ile Ser Val Gln Ala Leu Asn Ala Lys Pro Asp Thr Ala 
        115                 120                 125             


Glu Leu Thr Leu Leu Arg Pro Ile Gln Ala Leu Gly Thr Glu Tyr Phe 
    130                 135                 140                 


Val Leu Thr Pro Pro Gly Thr Ser Ala Arg Asn Val Lys Glu Phe Ala 
145                 150                 155                 160 


Val Val Ala Gly Ala Ala Gly Ala Ser Val Ser Val Thr Leu Lys Gly 
                165                 170                 175     


Ser Val Thr Phe Asn Gly Lys Phe Tyr Pro Ala Gly Asp Val Leu Arg 
            180                 185                 190         


Val Thr Leu Gln Pro Tyr Asn Val Ala Gln Leu Gln Ser Ser Val Asp 
        195                 200                 205             


Leu Ser Gly Ser Lys Val Thr Ala Ser Ser Pro Val Ala Val Leu Ser 
    210                 215                 220                 


Gly His Ser Cys Ala Gln Lys His Thr Thr Cys Asn His Val Val Glu 
225                 230                 235                 240 


Gln Leu Leu Pro Thr Ser Ala Trp Gly Thr His Tyr Val Val Pro Thr 
                245                 250                 255     


Leu Ala Ser Gln Ser Arg Tyr Asp Leu Ala Phe Val Val Ala Ser Gln 
            260                 265                 270         


Ala Thr Lys Leu Thr Tyr Asn His Gly Gly Ile Thr Gly Ser Arg Gly 
        275                 280                 285             


Leu Gln Ala Gly Asp Val Val Glu Phe Glu Val Arg Pro Ser Trp Pro 
    290                 295                 300                 


Leu Tyr Leu Ser Ala Asn Val Gly Ile Gln Val Leu Leu Phe Gly Thr 
305                 310                 315                 320 


Gly Ala Ile Arg Asn Glu Val Thr Tyr Asp Pro Tyr Leu Val Leu Ile 
                325                 330                 335     


Pro Asp Val Ala Ala Tyr Cys Pro Ala Tyr Val Val Lys Ser Val Pro 
            340                 345                 350         


Gly Cys Glu Gly Val Ala Leu Val Val Ala Gln Thr Lys Ala Ile Ser 
        355                 360                 365             


Gly Leu Thr Ile Asp Gly His Ala Val Gly Ala Lys Leu Thr Trp Glu 
    370                 375                 380                 


Ala Val Pro Gly Ser Glu Phe Ser Tyr Ala Glu Val Glu Leu Gly Thr 
385                 390                 395                 400 


Ala Asp Met Ile His Thr Ala Glu Ala Thr Thr Asn Leu Gly Leu Leu 
                405                 410                 415     


Thr Phe Gly Leu Ala Lys Ala Ile Gly Tyr Ala Thr Ala Ala Asp Cys 
            420                 425                 430         


Gly Arg Thr Val Leu Ser Pro Val Glu Pro Ser Cys Glu Gly Met Gln 
        435                 440                 445             


Cys Ala Ala Gly Gln Arg Cys Gln Val Val Gly Gly Lys Ala Gly Cys 
    450                 455                 460                 


Val Ala Glu Ser Thr Ala Val Cys Arg Ala Gln Gly Asp Pro His Tyr 
465                 470                 475                 480 


Thr Thr Phe Asp Gly Arg Arg Tyr Asp Met Met Gly Thr Cys Ser Tyr 
                485                 490                 495     


Thr Met Val Glu Leu Cys Ser Glu Asp Asp Thr Leu Pro Ala Phe Ser 
            500                 505                 510         


Val Glu Ala Lys Asn Glu His Arg Gly Ser Arg Arg Val Ser Tyr Val 
        515                 520                 525             


Gly Leu Val Thr Val Arg Ala Tyr Ser His Ser Val Ser Leu Thr Arg 
    530                 535                 540                 


Gly Glu Val Gly Phe Val Leu Val Asp Asn Gln Arg Ser Arg Leu Pro 
545                 550                 555                 560 


Val Ser Leu Ser Glu Gly Arg Leu Arg Val Tyr Gln Ser Gly Pro Arg 
                565                 570                 575     


Ala Val Val Glu Leu Val Phe Gly Leu Val Val Thr Tyr Asp Trp Asp 
            580                 585                 590         


Cys Gln Leu Ala Leu Ser Leu Pro Ala Arg Phe Gln Asp Gln Val Cys 
        595                 600                 605             


Gly Leu Cys Gly Asn Tyr Asn Gly Asp Pro Ala Asp Asp Phe Leu Thr 
    610                 615                 620                 


Pro Asp Gly Ala Leu Ala Pro Asp Ala Val Glu Phe Ala Ser Ser Trp 
625                 630                 635                 640 


Lys Leu Asp Asp Gly Asp Tyr Leu Cys Glu Asp Gly Cys Gln Asn Asn 
                645                 650                 655     


Cys Pro Ala Cys Thr Pro Gly Gln Ala Gln His Tyr Glu Gly Asp Arg 
            660                 665                 670         


Leu Cys Gly Met Leu Thr Lys Leu Asp Gly Pro Phe Ala Val Cys His 
        675                 680                 685             


Asp Thr Leu Asp Pro Arg Pro Phe Leu Glu Gln Cys Val Tyr Asp Leu 
    690                 695                 700                 


Cys Val Val Gly Gly Glu Arg Leu Ser Leu Cys Arg Gly Leu Ser Ala 
705                 710                 715                 720 


Tyr Ala Gln Ala Cys Leu Glu Leu Gly Ile Ser Val Gly Asp Trp Arg 
                725                 730                 735     


Ser Pro Ala Asn Cys Pro Leu Ser Cys Pro Ala Asn Ser Arg Tyr Glu 
            740                 745                 750         


Leu Cys Gly Pro Ala Cys Pro Thr Ser Cys Asn Gly Ala Ala Ala Pro 
        755                 760                 765             


Ser Asn Cys Ser Gly Arg Pro Cys Val Glu Gly Cys Val Cys Leu Pro 
    770                 775                 780                 


Gly Phe Val Ala Ser Gly Gly Ala Cys Val Pro Ala Ser Ser Cys Gly 
785                 790                 795                 800 


Cys Thr Phe Gln Gly Leu Gln Leu Ala Pro Gly Gln Glu Val Trp Ala 
                805                 810                 815     


Asp Glu Leu Cys Gln Arg Arg Cys Thr Cys Asn Gly Ala Thr His Gln 
            820                 825                 830         


Val Thr Cys Arg Asp Lys Gln Ser Cys Pro Ala Gly Glu Arg Cys Ser 
        835                 840                 845             


Val Gln Asn Gly Leu Leu Gly Cys Tyr Pro Asp Arg Phe Gly Thr Cys 
    850                 855                 860                 


Gln Gly Ser Gly Asp Pro His Tyr Val Ser Phe Asp Gly Arg Arg Phe 
865                 870                 875                 880 


Asp Phe Met Gly Thr Cys Thr Tyr Leu Leu Val Gly Ser Cys Gly Gln 
                885                 890                 895     


Asn Ala Ala Leu Pro Ala Phe Arg Val Leu Val Glu Asn Glu His Arg 
            900                 905                 910         


Gly Ser Gln Thr Val Ser Tyr Thr Arg Ala Val Arg Val Glu Ala Arg 
        915                 920                 925             


Gly Val Lys Val Ala Val Arg Arg Glu Tyr Pro Gly Gln Val Leu Val 
    930                 935                 940                 


Asp Asp Val Leu Gln Tyr Leu Pro Phe Gln Ala Ala Asp Gly Gln Val 
945                 950                 955                 960 


Gln Val Phe Arg Gln Gly Arg Asp Ala Val Val Arg Thr Asp Phe Gly 
                965                 970                 975     


Leu Thr Val Thr Tyr Asp Trp Asn Ala Arg Val Thr Ala Lys Val Pro 
            980                 985                 990         


Ser Ser Tyr Ala Glu Ala Leu Cys  Gly Leu Cys Gly Asn  Phe Asn Gly 
        995                 1000                 1005             


Asp Pro  Ala Asp Asp Leu Ala  Leu Arg Gly Gly Gly  Gln Ala Ala 
    1010                 1015                 1020             


Asn Ala  Leu Ala Phe Gly Asn  Ser Trp Gln Glu Glu  Thr Arg Pro 
    1025                 1030                 1035             


Gly Cys  Gly Ala Thr Glu Pro  Gly Asp Cys Pro Lys  Leu Asp Ser 
    1040                 1045                 1050             


Leu Val  Ala Gln Gln Leu Gln  Ser Lys Asn Glu Cys  Gly Ile Leu 
    1055                 1060                 1065             


Ala Asp  Pro Lys Gly Pro Phe  Arg Glu Cys His Ser  Lys Leu Asp 
    1070                 1075                 1080             


Pro Gln  Gly Ala Val Arg Asp  Cys Val Tyr Asp Arg  Cys Leu Leu 
    1085                 1090                 1095             


Pro Gly  Gln Ser Gly Pro Leu  Cys Asp Ala Leu Ala  Thr Tyr Ala 
    1100                 1105                 1110             


Ala Ala  Cys Gln Ala Ala Gly  Ala Thr Val His Pro  Trp Arg Ser 
    1115                 1120                 1125             


Glu Glu  Leu Cys Pro Leu Ser  Cys Pro Pro His Ser  His Tyr Glu 
    1130                 1135                 1140             


Ala Cys  Ser Tyr Gly Cys Pro  Leu Ser Cys Gly Asp  Leu Pro Val 
    1145                 1150                 1155             


Pro Gly  Gly Cys Gly Ser Glu  Cys His Glu Gly Cys  Val Cys Asp 
    1160                 1165                 1170             


Glu Gly  Phe Ala Leu Ser Gly  Glu Ser Cys Leu Pro  Leu Ala Ser 
    1175                 1180                 1185             


Cys Gly  Cys Val His Gln Gly  Thr Tyr His Pro Pro  Gly Gln Thr 
    1190                 1195                 1200             


Phe Tyr  Pro Gly Pro Gly Cys  Asp Ser Leu Cys His  Cys Gln Glu 
    1205                 1210                 1215             


Gly Gly  Leu Val Ser Cys Glu  Ser Ser Ser Cys Gly  Pro His Glu 
    1220                 1225                 1230             


Ala Cys  Gln Pro Ser Gly Gly  Ser Leu Gly Cys Val  Ala Val Gly 
    1235                 1240                 1245             


Ser Ser  Thr Cys Gln Ala Ser  Gly Asp Pro His Tyr  Thr Thr Phe 
    1250                 1255                 1260             


Asp Gly  Arg Arg Phe Asp Phe  Met Gly Thr Cys Val  Tyr Val Leu 
    1265                 1270                 1275             


Ala Gln  Thr Cys Gly Thr Arg  Pro Gly Leu His Arg  Phe Ala Val 
    1280                 1285                 1290             


Leu Gln  Glu Asn Val Ala Trp  Gly Asn Gly Arg Val  Ser Val Thr 
    1295                 1300                 1305             


Arg Val  Ile Thr Val Gln Val  Ala Asn Phe Thr Leu  Arg Leu Glu 
    1310                 1315                 1320             


Gln Arg  Gln Trp Lys Val Thr  Val Asn Gly Val Asp  Met Lys Leu 
    1325                 1330                 1335             


Pro Val  Val Leu Ala Asn Gly  Gln Ile Arg Ala Ser  Gln His Gly 
    1340                 1345                 1350             


Ser Asp  Val Val Ile Glu Thr  Asp Phe Gly Leu Arg  Val Ala Tyr 
    1355                 1360                 1365             


Asp Leu  Val Tyr Tyr Val Arg  Val Thr Val Pro Gly  Asn Tyr Tyr 
    1370                 1375                 1380             


Gln Gln  Met Cys Gly Leu Cys  Gly Asn Tyr Asn Gly  Asp Pro Lys 
    1385                 1390                 1395             


Asp Asp  Phe Gln Lys Pro Asn  Gly Ser Gln Ala Gly  Asn Ala Asn 
    1400                 1405                 1410             


Glu Phe  Gly Asn Ser Trp Glu  Glu Val Val Pro Asp  Ser Pro Cys 
    1415                 1420                 1425             


Leu Pro  Pro Thr Pro Cys Pro  Pro Gly Ser Glu Asp  Cys Ile Pro 
    1430                 1435                 1440             


Ser His  Lys Cys Pro Pro Glu  Leu Glu Lys Lys Tyr  Gln Lys Glu 
    1445                 1450                 1455             


Glu Phe  Cys Gly Leu Leu Ser  Ser Pro Thr Gly Pro  Leu Ser Ser 
    1460                 1465                 1470             


Cys His  Lys Leu Val Asp Pro  Gln Gly Pro Leu Lys  Asp Cys Ile 
    1475                 1480                 1485             


Phe Asp  Leu Cys Leu Gly Gly  Gly Asn Leu Ser Ile  Leu Cys Ser 
    1490                 1495                 1500             


Asn Ile  His Ala Tyr Val Ser  Ala Cys Gln Ala Ala  Gly Gly His 
    1505                 1510                 1515             


Val Glu  Pro Trp Arg Thr Glu  Thr Phe Cys Pro Met  Glu Cys Pro 
    1520                 1525                 1530             


Pro Asn  Ser His Tyr Glu Leu  Cys Ala Asp Thr Cys  Ser Leu Gly 
    1535                 1540                 1545             


Cys Ser  Ala Leu Ser Ala Pro  Pro Gln Cys Gln Asp  Gly Cys Ala 
    1550                 1555                 1560             


Glu Gly  Cys Gln Cys Asp Ser  Gly Phe Leu Tyr Asn  Gly Gln Ala 
    1565                 1570                 1575             


Cys Val  Pro Ile Gln Gln Cys  Gly Cys Tyr His Asn  Gly Val Tyr 
    1580                 1585                 1590             


Tyr Glu  Pro Glu Gln Thr Val  Leu Ile Asp Asn Cys  Arg Gln Gln 
    1595                 1600                 1605             


Cys Thr  Cys His Ala Gly Lys  Gly Met Val Cys Gln  Glu His Ser 
    1610                 1615                 1620             


Cys Lys  Pro Gly Gln Val Cys  Gln Pro Ser Gly Gly  Ile Leu Ser 
    1625                 1630                 1635             


Cys Val  Thr Lys Asp Pro Cys  His Gly Val Thr Cys  Arg Pro Gln 
    1640                 1645                 1650             


Glu Thr  Cys Lys Glu Gln Gly  Gly Gln Gly Val Cys  Leu Pro Asn 
    1655                 1660                 1665             


Tyr Glu  Ala Thr Cys Trp Leu  Trp Gly Asp Pro His  Tyr His Ser 
    1670                 1675                 1680             


Phe Asp  Gly Arg Lys Phe Asp  Phe Gln Gly Thr Cys  Asn Tyr Val 
    1685                 1690                 1695             


Leu Ala  Thr Thr Gly Cys Pro  Gly Val Ser Thr Gln  Gly Leu Thr 
    1700                 1705                 1710             


Pro Phe  Thr Val Thr Thr Lys  Asn Gln Asn Arg Gly  Asn Pro Ala 
    1715                 1720                 1725             


Val Ser  Tyr Val Arg Val Val  Thr Val Ala Ala Leu  Gly Thr Asn 
    1730                 1735                 1740             


Ile Ser  Ile His Lys Asp Glu  Ile Gly Lys Val Arg  Val Asn Gly 
    1745                 1750                 1755             


Val Leu  Thr Ala Leu Pro Val  Ser Val Ala Asp Gly  Arg Ile Ser 
    1760                 1765                 1770             


Val Thr  Gln Gly Ala Ser Lys  Ala Leu Leu Val Ala  Asp Phe Gly 
    1775                 1780                 1785             


Leu Gln  Val Ser Tyr Asp Trp  Asn Trp Arg Val Asp  Val Thr Leu 
    1790                 1795                 1800             


Pro Ser  Ser Tyr His Gly Ala  Val Cys Gly Leu Cys  Gly Asn Met 
    1805                 1810                 1815             


Asp Arg  Asn Pro Asn Asn Asp  Gln Val Phe Pro Asn  Gly Thr Leu 
    1820                 1825                 1830             


Ala Pro  Ser Ile Pro Ile Trp  Gly Gly Ser Trp Arg  Ala Pro Gly 
    1835                 1840                 1845             


Trp Asp  Pro Leu Cys Trp Asp  Glu Cys Arg Gly Ser  Cys Pro Thr 
    1850                 1855                 1860             


Cys Pro  Glu Asp Arg Leu Glu  Gln Tyr Glu Gly Pro  Gly Phe Cys 
    1865                 1870                 1875             


Gly Pro  Leu Ala Pro Gly Thr  Gly Gly Pro Phe Thr  Thr Cys His 
    1880                 1885                 1890             


Ala His  Val Pro Pro Glu Ser  Phe Phe Lys Gly Cys  Val Leu Asp 
    1895                 1900                 1905             


Val Cys  Met Gly Gly Gly Asp  Arg Asp Ile Leu Cys  Lys Ala Leu 
    1910                 1915                 1920             


Ala Ser  Tyr Val Ala Ala Cys  Gln Ala Ala Gly Val  Val Ile Glu 
    1925                 1930                 1935             


Asp Trp  Arg Ala Gln Val Gly  Cys Glu Ile Thr Cys  Pro Glu Asn 
    1940                 1945                 1950             


Ser His  Tyr Glu Val Cys Gly  Ser Pro Cys Pro Ala  Ser Cys Pro 
    1955                 1960                 1965             


Ser Pro  Ala Pro Leu Thr Thr  Pro Ala Val Cys Glu  Gly Pro Cys 
    1970                 1975                 1980             


Val Glu  Gly Cys Gln Cys Asp  Ala Gly Phe Val Leu  Ser Ala Asp 
    1985                 1990                 1995             


Arg Cys  Val Pro Leu Asn Asn  Gly Cys Gly Cys Trp  Ala Asn Gly 
    2000                 2005                 2010             


Thr Tyr  His Glu Ala Gly Ser  Glu Phe Trp Ala Asp  Gly Thr Cys 
    2015                 2020                 2025             


Ser Gln  Trp Cys Arg Cys Gly  Pro Gly Gly Gly Ser  Leu Val Cys 
    2030                 2035                 2040             


Thr Pro  Ala Ser Cys Gly Leu  Gly Glu Val Cys Gly  Leu Leu Pro 
    2045                 2050                 2055             


Ser Gly  Gln His Gly Cys Gln  Pro Val Ser Thr Ala  Glu Cys Gln 
    2060                 2065                 2070             


Ala Trp  Gly Asp Pro His Tyr  Val Thr Leu Asp Gly  His Arg Phe 
    2075                 2080                 2085             


Asn Phe  Gln Gly Thr Cys Glu  Tyr Leu Leu Ser Ala  Pro Cys His 
    2090                 2095                 2100             


Gly Pro  Pro Leu Gly Ala Glu  Asn Phe Thr Val Thr  Val Ala Asn 
    2105                 2110                 2115             


Glu His  Arg Gly Ser Gln Ala  Val Ser Tyr Thr Arg  Ser Val Thr 
    2120                 2125                 2130             


Leu Gln  Ile Tyr Asn His Ser  Leu Thr Leu Ser Ala  Arg Trp Pro 
    2135                 2140                 2145             


Arg Lys  Leu Gln Val Asp Gly  Val Phe Val Thr Leu  Pro Phe Gln 
    2150                 2155                 2160             


Leu Asp  Ser Leu Leu His Ala  His Leu Ser Gly Ala  Asp Val Val 
    2165                 2170                 2175             


Val Thr  Thr Thr Ser Gly Leu  Ser Leu Ala Phe Asp  Gly Asp Ser 
    2180                 2185                 2190             


Phe Val  Arg Leu Arg Val Pro  Ala Ala Tyr Ala Gly  Ser Leu Cys 
    2195                 2200                 2205             


Gly Leu  Cys Gly Asn Tyr Asn  Gln Asp Pro Ala Asp  Asp Leu Lys 
    2210                 2215                 2220             


Ala Val  Gly Gly Lys Pro Ala  Gly Trp Gln Val Gly  Gly Ala Gln 
    2225                 2230                 2235             


Gly Cys  Gly Glu Cys Val Ser  Lys Pro Cys Pro Ser  Pro Cys Thr 
    2240                 2245                 2250             


Pro Glu  Gln Gln Glu Ser Phe  Gly Gly Pro Asp Ala  Cys Gly Val 
    2255                 2260                 2265             


Ile Ser  Ala Thr Asp Gly Pro  Leu Ala Pro Cys His  Gly Leu Val 
    2270                 2275                 2280             


Pro Pro  Ala Gln Tyr Phe Gln  Gly Cys Leu Leu Asp  Ala Cys Gln 
    2285                 2290                 2295             


Val Gln  Gly His Pro Gly Gly  Leu Cys Pro Ala Val  Ala Thr Tyr 
    2300                 2305                 2310             


Val Ala  Ala Cys Gln Ala Ala  Gly Ala Gln Leu Arg  Glu Trp Arg 
    2315                 2320                 2325             


Arg Pro  Asp Phe Cys Pro Phe  Gln Cys Pro Ala His  Ser His Tyr 
    2330                 2335                 2340             


Glu Leu  Cys Gly Asp Ser Cys  Pro Gly Ser Cys Pro  Ser Leu Ser 
    2345                 2350                 2355             


Ala Pro  Glu Gly Cys Glu Ser  Ala Cys Arg Glu Gly  Cys Val Cys 
    2360                 2365                 2370             


Asp Ala  Gly Phe Val Leu Ser  Gly Asp Thr Cys Val  Pro Val Gly 
    2375                 2380                 2385             


Gln Cys  Gly Cys Leu His Asp  Asp Arg Tyr Tyr Pro  Leu Gly Gln 
    2390                 2395                 2400             


Thr Phe  Tyr Pro Gly Pro Gly  Cys Asp Ser Leu Cys  Arg Cys Arg 
    2405                 2410                 2415             


Glu Gly  Gly Glu Val Ser Cys  Glu Pro Ser Ser Cys  Gly Pro His 
    2420                 2425                 2430             


Glu Thr  Cys Arg Pro Ser Gly  Gly Ser Leu Gly Cys  Val Ala Val 
    2435                 2440                 2445             


Gly Ser  Thr Thr Cys Gln Ala  Ser Gly Asp Pro His  Tyr Thr Thr 
    2450                 2455                 2460             


Phe Asp  Gly Arg Arg Phe Asp  Phe Met Gly Thr Cys  Val Tyr Val 
    2465                 2470                 2475             


Leu Ala  Gln Thr Cys Gly Thr  Arg Pro Gly Leu His  Arg Phe Ala 
    2480                 2485                 2490             


Val Leu  Gln Glu Asn Val Ala  Trp Gly Asn Gly Arg  Val Ser Val 
    2495                 2500                 2505             


Thr Arg  Val Ile Thr Val Gln  Val Ala Asn Phe Thr  Leu Arg Leu 
    2510                 2515                 2520             


Glu Gln  Arg Gln Trp Lys Val  Thr Val Asn Gly Val  Asp Met Lys 
    2525                 2530                 2535             


Leu Pro  Val Val Leu Ala Asn  Gly Gln Ile Arg Ala  Ser Gln His 
    2540                 2545                 2550             


Gly Ser  Asp Val Val Ile Glu  Thr Asp Phe Gly Leu  Arg Val Ala 
    2555                 2560                 2565             


Tyr Asp  Leu Val Tyr Tyr Val  Arg Val Thr Val Pro  Gly Asn Tyr 
    2570                 2575                 2580             


Tyr Gln  Leu Met Cys Gly Leu  Cys Gly Asn Tyr Asn  Gly Asp Pro 
    2585                 2590                 2595             


Lys Asp  Asp Phe Gln Lys Pro  Asn Gly Ser Gln Ala  Gly Asn Ala 
    2600                 2605                 2610             


Asn Glu  Phe Gly Asn Ser Trp  Glu Glu Val Val Pro  Asp Ser Pro 
    2615                 2620                 2625             


Cys Leu  Pro Pro Pro Thr Cys  Pro Pro Gly Ser Glu  Gly Cys Ile 
    2630                 2635                 2640             


Pro Ser  Glu Glu Cys Pro Pro  Glu Leu Glu Lys Lys  Tyr Gln Lys 
    2645                 2650                 2655             


Glu Glu  Phe Cys Gly Leu Leu  Ser Ser Pro Thr Gly  Pro Leu Ser 
    2660                 2665                 2670             


Ser Cys  His Lys Leu Val Asp  Pro Gln Gly Pro Leu  Lys Asp Cys 
    2675                 2680                 2685             


Ile Phe  Asp Leu Cys Leu Gly  Gly Gly Asn Leu Ser  Ile Leu Cys 
    2690                 2695                 2700             


Ser Asn  Ile His Ala Tyr Val  Ser Ala Cys Gln Ala  Ala Gly Gly 
    2705                 2710                 2715             


Gln Val  Glu Pro Trp Arg Asn  Glu Thr Phe Cys Pro  Met Glu Cys 
    2720                 2725                 2730             


Pro Gln  Asn Ser His Tyr Glu  Leu Cys Ala Asp Thr  Cys Ser Leu 
    2735                 2740                 2745             


Gly Cys  Ser Ala Leu Ser Ala  Pro Leu Gln Cys Pro  Asp Gly Cys 
    2750                 2755                 2760             


Ala Glu  Gly Cys Gln Cys Asp  Ser Gly Phe Leu Tyr  Asn Gly Gln 
    2765                 2770                 2775             


Ala Cys  Val Pro Ile Gln Gln  Cys Gly Cys Tyr His  Asn Gly Ala 
    2780                 2785                 2790             


Tyr Tyr  Glu Pro Glu Gln Thr  Val Leu Ile Asp Asn  Cys Arg Gln 
    2795                 2800                 2805             


Gln Cys  Thr Cys His Val Gly  Lys Val Val Val Cys  Gln Glu His 
    2810                 2815                 2820             


Ser Cys  Lys Pro Gly Gln Val  Cys Gln Pro Ser Gly  Gly Ile Leu 
    2825                 2830                 2835             


Ser Cys  Val Asn Lys Asp Pro  Cys His Gly Val Thr  Cys Arg Pro 
    2840                 2845                 2850             


Gln Glu  Thr Cys Lys Glu Gln  Gly Gly Gln Gly Val  Cys Leu Pro 
    2855                 2860                 2865             


Asn Tyr  Glu Ala Thr Cys Trp  Leu Trp Gly Asp Pro  His Tyr His 
    2870                 2875                 2880             


Ser Phe  Asp Gly Arg Lys Phe  Asp Phe Gln Gly Thr  Cys Asn Tyr 
    2885                 2890                 2895             


Val Leu  Ala Thr Thr Gly Cys  Pro Gly Val Ser Thr  Gln Gly Leu 
    2900                 2905                 2910             


Thr Pro  Phe Thr Val Thr Thr  Lys Asn Gln Asn Arg  Gly Asn Pro 
    2915                 2920                 2925             


Ala Val  Ser Tyr Val Arg Val  Val Thr Val Ala Ala  Leu Gly Thr 
    2930                 2935                 2940             


Asn Ile  Ser Ile His Lys Asp  Glu Ile Gly Lys Val  Arg Val Asn 
    2945                 2950                 2955             


Gly Val  Leu Thr Ala Leu Pro  Val Ser Val Ala Asp  Gly Arg Ile 
    2960                 2965                 2970             


Ser Val  Thr Gln Gly Ala Ser  Lys Ala Leu Leu Val  Ala Asp Phe 
    2975                 2980                 2985             


Gly Leu  Gln Val Ser Tyr Asp  Trp Asn Trp Arg Val  Asp Val Thr 
    2990                 2995                 3000             


Leu Pro  Ser Ser Tyr His Gly  Ala Val Cys Gly Leu  Cys Gly Asn 
    3005                 3010                 3015             


Met Asp  Arg Asn Pro Asn Asn  Asp Gln Val Phe Pro  Asn Gly Thr 
    3020                 3025                 3030             


Leu Ala  Pro Ser Ile Pro Ile  Trp Gly Gly Ser Trp  Arg Ala Pro 
    3035                 3040                 3045             


Gly Trp  Asp Pro Leu Cys Trp  Asp Glu Cys Arg Gly  Ser Cys Pro 
    3050                 3055                 3060             


Thr Cys  Pro Glu Asp Arg Leu  Glu Gln Tyr Glu Gly  Pro Gly Phe 
    3065                 3070                 3075             


Cys Gly  Pro Leu Ala Pro Gly  Thr Gly Gly Pro Phe  Thr Thr Cys 
    3080                 3085                 3090             


His Ala  His Val Pro Pro Glu  Ser Phe Phe Lys Gly  Cys Val Leu 
    3095                 3100                 3105             


Asp Val  Cys Met Gly Gly Gly  Asp Arg Asp Ile Leu  Cys Lys Ala 
    3110                 3115                 3120             


Leu Ala  Ser Tyr Val Ala Ala  Cys Gln Ala Ala Gly  Val Val Ile 
    3125                 3130                 3135             


Glu Asp  Trp Arg Ala Gln Val  Gly Cys Glu Ile Thr  Cys Pro Glu 
    3140                 3145                 3150             


Asn Ser  His Tyr Glu Val Cys  Gly Pro Pro Cys Pro  Ala Ser Cys 
    3155                 3160                 3165             


Pro Ser  Pro Ala Pro Leu Thr  Thr Pro Ala Val Cys  Glu Gly Pro 
    3170                 3175                 3180             


Cys Val  Glu Gly Cys Gln Cys  Asp Ala Gly Phe Val  Leu Ser Ala 
    3185                 3190                 3195             


Asp Arg  Cys Val Pro Leu Asn  Asn Gly Cys Gly Cys  Trp Ala Asn 
    3200                 3205                 3210             


Gly Thr  Tyr His Glu Ala Gly  Ser Glu Phe Trp Ala  Asp Gly Thr 
    3215                 3220                 3225             


Cys Ser  Gln Trp Cys Arg Cys  Gly Pro Gly Gly Gly  Ser Leu Val 
    3230                 3235                 3240             


Cys Thr  Pro Ala Ser Cys Gly  Leu Gly Glu Val Cys  Gly Leu Leu 
    3245                 3250                 3255             


Pro Ser  Gly Gln His Gly Cys  Gln Pro Val Ser Thr  Ala Glu Cys 
    3260                 3265                 3270             


Gln Ala  Trp Gly Asp Pro His  Tyr Val Thr Leu Asp  Gly His Arg 
    3275                 3280                 3285             


Phe Asp  Phe Gln Gly Thr Cys  Glu Tyr Leu Leu Ser  Ala Pro Cys 
    3290                 3295                 3300             


His Gly  Pro Pro Leu Gly Ala  Glu Asn Phe Thr Val  Thr Val Ala 
    3305                 3310                 3315             


Asn Glu  His Arg Gly Ser Gln  Ala Val Ser Tyr Thr  Arg Ser Val 
    3320                 3325                 3330             


Thr Leu  Gln Ile Tyr Asn His  Ser Leu Thr Leu Ser  Ala Arg Trp 
    3335                 3340                 3345             


Pro Arg  Lys Leu Gln Val Asp  Gly Val Phe Val Thr  Leu Pro Phe 
    3350                 3355                 3360             


Gln Leu  Asp Ser Leu Leu His  Ala His Leu Ser Gly  Ala Asp Val 
    3365                 3370                 3375             


Val Val  Thr Thr Thr Ser Gly  Leu Ser Leu Ala Phe  Asp Gly Asp 
    3380                 3385                 3390             


Ser Phe  Val Arg Leu Arg Val  Pro Ala Ala Tyr Ala  Gly Ser Leu 
    3395                 3400                 3405             


Cys Gly  Leu Cys Gly Asn Tyr  Asn Gln Asp Pro Ala  Asp Asp Leu 
    3410                 3415                 3420             


Lys Ala  Val Gly Gly Lys Pro  Ala Gly Trp Gln Val  Gly Gly Ala 
    3425                 3430                 3435             


Gln Gly  Cys Gly Glu Cys Val  Ser Lys Pro Cys Pro  Ser Pro Cys 
    3440                 3445                 3450             


Thr Pro  Glu Gln Gln Glu Ser  Phe Gly Gly Pro Asp  Ala Cys Gly 
    3455                 3460                 3465             


Val Ile  Ser Ala Thr Asp Gly  Pro Leu Ala Pro Cys  His Gly Leu 
    3470                 3475                 3480             


Val Pro  Pro Ala Gln Tyr Phe  Gln Gly Cys Leu Leu  Asp Ala Cys 
    3485                 3490                 3495             


Gln Val  Gln Gly His Pro Gly  Gly Leu Cys Pro Ala  Val Ala Thr 
    3500                 3505                 3510             


Tyr Val  Ala Ala Cys Gln Ala  Ala Gly Ala Gln Leu  Arg Glu Trp 
    3515                 3520                 3525             


Arg Arg  Pro Asp Phe Cys Pro  Phe Gln Cys Pro Ala  His Ser His 
    3530                 3535                 3540             


Tyr Glu  Leu Cys Gly Asp Ser  Cys Pro Gly Ser Cys  Pro Ser Leu 
    3545                 3550                 3555             


Ser Ala  Pro Glu Gly Cys Glu  Ser Ala Cys Arg Glu  Gly Cys Val 
    3560                 3565                 3570             


Cys Asp  Ala Gly Phe Val Leu  Ser Gly Asp Thr Cys  Val Pro Val 
    3575                 3580                 3585             


Gly Gln  Cys Gly Cys Leu His  Asp Asp Arg Tyr Tyr  Pro Leu Gly 
    3590                 3595                 3600             


Gln Thr  Phe Tyr Pro Gly Pro  Gly Cys Asp Ser Leu  Cys Arg Cys 
    3605                 3610                 3615             


Arg Glu  Gly Gly Glu Val Ser  Cys Glu Pro Ser Ser  Cys Gly Pro 
    3620                 3625                 3630             


His Glu  Thr Cys Arg Pro Ser  Gly Gly Ser Leu Gly  Cys Val Ala 
    3635                 3640                 3645             


Val Gly  Ser Thr Thr Cys Gln  Ala Ser Gly Asp Pro  His Tyr Thr 
    3650                 3655                 3660             


Thr Phe  Asp Gly His Arg Phe  Asp Phe Met Gly Thr  Cys Val Tyr 
    3665                 3670                 3675             


Val Leu  Ala Gln Thr Cys Gly  Thr Arg Pro Gly Leu  His Arg Phe 
    3680                 3685                 3690             


Ala Val  Leu Gln Glu Asn Val  Ala Trp Gly Asn Gly  Arg Val Ser 
    3695                 3700                 3705             


Val Thr  Arg Val Ile Thr Val  Gln Val Ala Asn Phe  Thr Leu Arg 
    3710                 3715                 3720             


Leu Glu  Gln Arg Gln Trp Lys  Val Thr Val Asn Gly  Val Asp Met 
    3725                 3730                 3735             


Lys Leu  Pro Val Val Leu Ala  Asn Gly Gln Ile Arg  Ala Ser Gln 
    3740                 3745                 3750             


His Gly  Ser Asp Val Val Ile  Glu Thr Asp Phe Gly  Leu Arg Val 
    3755                 3760                 3765             


Ala Tyr  Asp Leu Val Tyr Tyr  Val Arg Val Thr Val  Pro Gly Asn 
    3770                 3775                 3780             


Tyr Tyr  Gln Leu Met Cys Gly  Leu Cys Gly Asn Tyr  Asn Gly Asp 
    3785                 3790                 3795             


Pro Lys  Asp Asp Phe Gln Lys  Pro Asn Gly Ser Gln  Ala Gly Asn 
    3800                 3805                 3810             


Ala Asn  Glu Phe Gly Asn Ser  Trp Glu Glu Val Val  Pro Asp Ser 
    3815                 3820                 3825             


Pro Cys  Leu Pro Pro Pro Thr  Cys Pro Pro Gly Ser  Ala Gly Cys 
    3830                 3835                 3840             


Ile Pro  Ser Asp Lys Cys Pro  Pro Glu Leu Glu Lys  Lys Tyr Gln 
    3845                 3850                 3855             


Lys Glu  Glu Phe Cys Gly Leu  Leu Ser Ser Pro Thr  Gly Pro Leu 
    3860                 3865                 3870             


Ser Ser  Cys His Lys Leu Val  Asp Pro Gln Gly Pro  Leu Lys Asp 
    3875                 3880                 3885             


Cys Ile  Phe Asp Leu Cys Leu  Gly Gly Gly Asn Leu  Ser Ile Leu 
    3890                 3895                 3900             


Cys Ser  Asn Ile His Ala Tyr  Val Ser Ala Cys Gln  Ala Ala Gly 
    3905                 3910                 3915             


Gly His  Val Glu Pro Trp Arg  Asn Glu Thr Phe Cys  Pro Met Glu 
    3920                 3925                 3930             


Cys Pro  Gln Asn Ser His Tyr  Glu Leu Cys Ala Asp  Thr Cys Ser 
    3935                 3940                 3945             


Leu Gly  Cys Ser Ala Leu Ser  Ala Pro Leu Gln Cys  Pro Asp Gly 
    3950                 3955                 3960             


Cys Ala  Glu Gly Cys Gln Cys  Asp Ser Gly Phe Leu  Tyr Asn Gly 
    3965                 3970                 3975             


Gln Ala  Cys Val Pro Ile Gln  Gln Cys Gly Cys Tyr  His Asn Gly 
    3980                 3985                 3990             


Val Tyr  Tyr Glu Pro Glu Gln  Thr Val Leu Ile Asp  Asn Cys Arg 
    3995                 4000                 4005             


Gln Gln  Cys Thr Cys His Val  Gly Lys Val Val Val  Cys Gln Glu 
    4010                 4015                 4020             


His Ser  Cys Lys Pro Gly Gln  Val Cys Gln Pro Ser  Gly Gly Ile 
    4025                 4030                 4035             


Leu Ser  Cys Val Thr Lys Asp  Pro Cys His Gly Val  Thr Cys Arg 
    4040                 4045                 4050             


Pro Gln  Glu Thr Cys Lys Glu  Gln Gly Gly Gln Gly  Val Cys Leu 
    4055                 4060                 4065             


Pro Asn  Tyr Glu Ala Thr Cys  Trp Leu Trp Gly Asp  Pro His Tyr 
    4070                 4075                 4080             


His Ser  Phe Asp Gly Arg Lys  Phe Asp Phe Gln Gly  Thr Cys Asn 
    4085                 4090                 4095             


Tyr Val  Leu Ala Thr Thr Gly  Cys Pro Gly Val Ser  Thr Gln Gly 
    4100                 4105                 4110             


Leu Thr  Pro Phe Thr Val Thr  Thr Lys Asn Gln Asn  Arg Gly Asn 
    4115                 4120                 4125             


Pro Ala  Val Ser Tyr Val Arg  Val Val Thr Val Ala  Ala Leu Gly 
    4130                 4135                 4140             


Thr Asn  Ile Ser Ile His Lys  Asp Glu Ile Gly Lys  Val Arg Val 
    4145                 4150                 4155             


Asn Gly  Val Leu Thr Ala Leu  Pro Val Ser Val Ala  Asp Gly Arg 
    4160                 4165                 4170             


Ile Ser  Val Ala Gln Gly Ala  Ser Lys Ala Leu Leu  Val Ala Asp 
    4175                 4180                 4185             


Phe Gly  Leu Gln Val Ser Tyr  Asp Trp Asn Trp Arg  Val Asp Val 
    4190                 4195                 4200             


Thr Leu  Pro Ser Ser Tyr His  Gly Ala Val Cys Gly  Leu Cys Gly 
    4205                 4210                 4215             


Asn Met  Asp Arg Asn Pro Asn  Asn Asp Gln Val Phe  Pro Asn Gly 
    4220                 4225                 4230             


Thr Leu  Ala Pro Ser Ile Pro  Ile Trp Gly Gly Ser  Trp Arg Ala 
    4235                 4240                 4245             


Pro Gly  Trp Asp Pro Leu Cys  Trp Asp Glu Cys Arg  Gly Ser Cys 
    4250                 4255                 4260             


Pro Thr  Cys Pro Glu Asp Arg  Leu Glu Gln Tyr Glu  Gly Pro Gly 
    4265                 4270                 4275             


Phe Cys  Gly Pro Leu Ser Ser  Gly Thr Gly Gly Pro  Phe Thr Thr 
    4280                 4285                 4290             


Cys His  Ala His Val Pro Pro  Glu Ser Phe Phe Lys  Gly Cys Val 
    4295                 4300                 4305             


Leu Asp  Val Cys Met Gly Gly  Gly Asp Arg Asp Ile  Leu Cys Lys 
    4310                 4315                 4320             


Ala Leu  Ala Ser Tyr Val Ala  Ala Cys Gln Ala Ala  Gly Val Val 
    4325                 4330                 4335             


Ile Glu  Asp Trp Arg Ala Gln  Val Gly Cys Glu Ile  Thr Cys Pro 
    4340                 4345                 4350             


Glu Asn  Ser His Tyr Glu Val  Cys Gly Pro Pro Cys  Pro Ala Ser 
    4355                 4360                 4365             


Cys Pro  Ser Pro Ala Pro Leu  Thr Thr Pro Ala Val  Cys Glu Gly 
    4370                 4375                 4380             


Pro Cys  Val Glu Gly Cys Gln  Cys Asp Ala Gly Phe  Val Leu Ser 
    4385                 4390                 4395             


Ala Asp  Arg Cys Val Pro Leu  Asn Asn Gly Cys Gly  Cys Trp Ala 
    4400                 4405                 4410             


Asn Gly  Thr Tyr His Glu Ala  Gly Ser Glu Phe Trp  Ala Asp Gly 
    4415                 4420                 4425             


Thr Cys  Ser Gln Trp Cys Arg  Cys Gly Pro Gly Gly  Gly Ser Leu 
    4430                 4435                 4440             


Val Cys  Thr Pro Ala Ser Cys  Gly Leu Gly Glu Val  Cys Gly Leu 
    4445                 4450                 4455             


Leu Pro  Ser Gly Gln His Gly  Cys Gln Pro Val Ser  Thr Ala Glu 
    4460                 4465                 4470             


Cys Gln  Ala Trp Gly Asp Pro  His Tyr Val Thr Leu  Asp Gly His 
    4475                 4480                 4485             


Arg Phe  Asp Phe Gln Gly Thr  Cys Glu Tyr Leu Leu  Ser Ala Pro 
    4490                 4495                 4500             


Cys His  Gly Pro Pro Leu Gly  Ala Glu Asn Phe Thr  Val Thr Val 
    4505                 4510                 4515             


Ala Asn  Glu His Arg Gly Ser  Gln Ala Val Ser Tyr  Thr Arg Ser 
    4520                 4525                 4530             


Val Thr  Leu Gln Ile Tyr Asn  His Ser Leu Thr Leu  Ser Ala Arg 
    4535                 4540                 4545             


Trp Pro  Arg Lys Leu Gln Val  Asp Gly Val Phe Val  Ala Leu Pro 
    4550                 4555                 4560             


Phe Gln  Leu Asp Ser Leu Leu  His Ala His Leu Ser  Gly Ala Asp 
    4565                 4570                 4575             


Val Val  Val Thr Thr Thr Ser  Gly Leu Ser Leu Ala  Phe Asp Gly 
    4580                 4585                 4590             


Asp Ser  Phe Val Arg Leu Arg  Val Pro Ala Ala Tyr  Ala Ala Ser 
    4595                 4600                 4605             


Leu Cys  Gly Leu Cys Gly Asn  Tyr Asn Gln Asp Pro  Ala Asp Asp 
    4610                 4615                 4620             


Leu Lys  Ala Val Gly Gly Lys  Pro Ala Gly Trp Gln  Val Gly Gly 
    4625                 4630                 4635             


Ala Gln  Gly Cys Gly Glu Cys  Val Ser Lys Pro Cys  Pro Ser Pro 
    4640                 4645                 4650             


Cys Thr  Pro Glu Gln Gln Glu  Ser Phe Gly Gly Pro  Asp Ala Cys 
    4655                 4660                 4665             


Gly Val  Ile Ser Ala Thr Asp  Gly Pro Leu Ala Pro  Cys His Gly 
    4670                 4675                 4680             


Leu Val  Pro Pro Ala Gln Tyr  Phe Gln Gly Cys Leu  Leu Asp Ala 
    4685                 4690                 4695             


Cys Gln  Val Gln Gly His Pro  Gly Gly Leu Cys Pro  Ala Val Ala 
    4700                 4705                 4710             


Thr Tyr  Val Ala Ala Cys Gln  Ala Ala Gly Ala Gln  Leu Gly Glu 
    4715                 4720                 4725             


Trp Arg  Arg Pro Asp Phe Cys  Pro Leu Gln Cys Pro  Ala His Ser 
    4730                 4735                 4740             


His Tyr  Glu Leu Cys Gly Asp  Ser Cys Pro Val Ser  Cys Pro Ser 
    4745                 4750                 4755             


Leu Ser  Ala Pro Glu Gly Cys  Glu Ser Ala Cys Arg  Glu Gly Cys 
    4760                 4765                 4770             


Val Cys  Asp Ala Gly Phe Val  Leu Ser Gly Asp Thr  Cys Val Pro 
    4775                 4780                 4785             


Val Gly  Gln Cys Gly Cys Leu  His Asp Gly Arg Tyr  Tyr Pro Leu 
    4790                 4795                 4800             


Gly Glu  Val Phe Tyr Pro Gly  Pro Glu Cys Glu Arg  Arg Cys Glu 
    4805                 4810                 4815             


Cys Gly  Pro Gly Gly His Val  Thr Cys Gln Glu Gly  Ala Ala Cys 
    4820                 4825                 4830             


Gly Pro  His Glu Glu Cys Arg  Leu Glu Asp Gly Val  Gln Ala Cys 
    4835                 4840                 4845             


His Ala  Thr Gly Cys Gly Arg  Cys Leu Ala Asn Gly  Gly Ile His 
    4850                 4855                 4860             


Tyr Ile  Thr Leu Asp Gly Arg  Val Tyr Asp Leu His  Gly Ser Cys 
    4865                 4870                 4875             


Ser Tyr  Val Leu Ala Gln Val  Cys His Pro Lys Pro  Gly Asp Glu 
    4880                 4885                 4890             


Asp Phe  Ser Ile Val Leu Glu  Lys Asn Ala Ala Gly  Asp Leu Gln 
    4895                 4900                 4905             


Arg Leu  Leu Val Thr Val Ala  Gly Gln Val Val Ser  Leu Ala Gln 
    4910                 4915                 4920             


Gly Gln  Gln Val Thr Val Asp  Gly Glu Ala Val Ala  Leu Pro Val 
    4925                 4930                 4935             


Ala Val  Gly Arg Val Arg Val  Thr Ala Glu Gly Arg  Asn Met Val 
    4940                 4945                 4950             


Leu Gln  Thr Thr Lys Gly Leu  Arg Leu Leu Phe Asp  Gly Asp Ala 
    4955                 4960                 4965             


His Leu  Leu Met Ser Ile Pro  Ser Pro Phe Arg Gly  Arg Leu Cys 
    4970                 4975                 4980             


Gly Leu  Cys Gly Asn Phe Asn  Gly Asn Trp Ser Asp  Asp Phe Val 
    4985                 4990                 4995             


Leu Pro  Asn Gly Ser Ala Ala  Ser Ser Val Glu Thr  Phe Gly Ala 
    5000                 5005                 5010             


Ala Trp  Arg Ala Pro Gly Ser  Ser Lys Gly Cys Gly  Glu Gly Cys 
    5015                 5020                 5025             


Gly Pro  Gln Gly Cys Pro Val  Cys Leu Ala Glu Glu  Thr Ala Pro 
    5030                 5035                 5040             


Tyr Glu  Ser Asn Glu Ala Cys  Gly Gln Leu Arg Asn  Pro Gln Gly 
    5045                 5050                 5055             


Pro Phe  Ala Thr Cys Gln Ala  Val Leu Ser Pro Ser  Glu Tyr Phe 
    5060                 5065                 5070             


Arg Gln  Cys Val Tyr Asp Leu  Cys Ala Gln Lys Gly  Asp Lys Ala 
    5075                 5080                 5085             


Phe Leu  Cys Arg Ser Leu Ala  Ala Tyr Thr Ala Ala  Cys Gln Ala 
    5090                 5095                 5100             


Ala Gly  Val Ala Val Lys Pro  Trp Arg Thr Asp Ser  Phe Cys Pro 
    5105                 5110                 5115             


Leu His  Cys Pro Ala His Ser  His Tyr Ser Ile Cys  Thr Arg Thr 
    5120                 5125                 5130             


Cys Gln  Gly Ser Cys Ala Ala  Leu Ser Gly Leu Thr  Gly Cys Thr 
    5135                 5140                 5145             


Thr Arg  Cys Phe Glu Gly Cys  Glu Cys Asp Asp Arg  Phe Leu Leu 
    5150                 5155                 5160             


Ser Gln  Gly Val Cys Ile Pro  Val Gln Asp Cys Gly  Cys Thr His 
    5165                 5170                 5175             


Asn Gly  Arg Tyr Leu Pro Val  Asn Ser Ser Leu Leu  Thr Ser Asp 
    5180                 5185                 5190             


Cys Ser  Glu Arg Cys Ser Cys  Ser Ser Ser Ser Gly  Leu Thr Cys 
    5195                 5200                 5205             


Gln Ala  Ala Gly Cys Pro Pro  Gly Arg Val Cys Glu  Val Lys Ala 
    5210                 5215                 5220             


Glu Ala  Arg Asn Cys Trp Ala  Thr Arg Gly Leu Cys  Val Leu Ser 
    5225                 5230                 5235             


Val Gly  Ala Asn Leu Thr Thr  Phe Asp Gly Ala Arg  Gly Ala Thr 
    5240                 5245                 5250             


Thr Ser  Pro Gly Val Tyr Glu  Leu Ser Ser Arg Cys  Pro Gly Leu 
    5255                 5260                 5265             


Gln Asn  Thr Ile Pro Trp Tyr  Arg Val Val Ala Glu  Val Gln Ile 
    5270                 5275                 5280             


Cys His  Gly Lys Thr Glu Ala  Val Gly Gln Val His  Ile Phe Phe 
    5285                 5290                 5295             


Gln Asp  Gly Met Val Thr Leu  Thr Pro Asn Lys Gly  Val Trp Val 
    5300                 5305                 5310             


Asn Gly  Leu Arg Val Asp Leu  Pro Ala Glu Lys Leu  Ala Ser Val 
    5315                 5320                 5325             


Ser Val  Ser Arg Thr Pro Asp  Gly Ser Leu Leu Val  Arg Gln Lys 
    5330                 5335                 5340             


Ala Gly  Val Gln Val Trp Leu  Gly Ala Asn Gly Lys  Val Ala Val 
    5345                 5350                 5355             


Ile Val  Ser Asn Asp His Ala  Gly Lys Leu Cys Gly  Ala Cys Gly 
    5360                 5365                 5370             


Asn Phe  Asp Gly Asp Gln Thr  Asn Asp Trp His Asp  Ser Gln Glu 
    5375                 5380                 5385             


Lys Pro  Ala Met Glu Lys Trp  Arg Ala Gln Asp Phe  Ser Pro Cys 
    5390                 5395                 5400             


Tyr Gly  
    5405 


<210>  3959
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCGR2A__Homo_sapiens__NP_001129691

<400>  3959

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
        35                  40                  45              


Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
    50                  55                  60                  


Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
65                  70                  75                  80  


Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
            100                 105                 110         


Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
        115                 120                 125             


Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
    130                 135                 140                 


Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
145                 150                 155                 160 


Lys Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
            180                 185                 190         


Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
        195                 200                 205             


Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
    210                 215                 220                 


Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
225                 230                 235                 240 


Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                245                 250                 255     


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            260                 265                 270         


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        275                 280                 285             


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    290                 295                 300                 


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315         


<210>  3960
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCGR2B__Homo_sapiens__NP_001002273

<400>  3960

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Pro Pro Lys 
        35                  40                  45              


Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu Asp 
    50                  55                  60                  


Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp Ser 
65                  70                  75                  80  


Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln Pro 
                85                  90                  95      


Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr Cys 
            100                 105                 110         


Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val Leu 
        115                 120                 125             


Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu Gly 
    130                 135                 140                 


Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu Val 
145                 150                 155                 160 


Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg Ser 
                165                 170                 175     


Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly Asp 
            180                 185                 190         


Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys Pro 
        195                 200                 205             


Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile Ile 
    210                 215                 220                 


Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala Val 
225                 230                 235                 240 


Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Pro Thr 
                245                 250                 255     


Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn Thr Ile Thr Tyr 
            260                 265                 270         


Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln Asn 
        275                 280                 285             


Arg Ile 
    290 


<210>  3961
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCGR3A__Homo_sapiens__NP_000560

<400>  3961

Met Gly Gly Gly Ala Gly Glu Arg Leu Phe Thr Ser Ser Cys Leu Val 
1               5                   10                  15      


Gly Leu Val Pro Leu Gly Leu Arg Ile Ser Leu Val Thr Cys Pro Leu 
            20                  25                  30          


Gln Cys Gly Ile Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu 
        35                  40                  45              


Leu Val Ser Ala Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val 
    50                  55                  60                  


Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr 
65                  70                  75                  80  


Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp 
                85                  90                  95      


Phe His Asn Glu Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile 
            100                 105                 110         


Asp Ala Ala Thr Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn 
        115                 120                 125             


Leu Ser Thr Leu Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp 
    130                 135                 140                 


Leu Leu Leu Gln Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile 
145                 150                 155                 160 


His Leu Arg Cys His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr 
                165                 170                 175     


Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp 
            180                 185                 190         


Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys 
        195                 200                 205             


Arg Gly Leu Phe Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile 
    210                 215                 220                 


Thr Ile Thr Gln Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 
225                 230                 235                 240 


Pro Gly Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala 
                245                 250                 255     


Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser 
            260                 265                 270         


Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln 
        275                 280                 285             


Asp Lys 
    290 


<210>  3962
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCGR3B__Homo_sapiens__NP_000561

<400>  3962

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Asn Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230             


<210>  3963
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCGRT__Homo_sapiens__NP_001129491

<400>  3963

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  3964
<211>  891
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCHO1__Homo_sapiens__NP_001154829

<400>  3964

Met Ser Tyr Phe Gly Glu His Phe Trp Gly Glu Lys Asn His Gly Phe 
1               5                   10                  15      


Glu Val Leu Tyr His Ser Val Lys Gln Gly Pro Ile Ser Thr Lys Glu 
            20                  25                  30          


Leu Ala Asp Phe Ile Arg Glu Arg Ala Thr Ile Glu Glu Thr Tyr Ser 
        35                  40                  45              


Lys Ala Met Ala Lys Leu Ser Lys Leu Ala Ser Asn Gly Thr Pro Met 
    50                  55                  60                  


Gly Thr Phe Ala Pro Leu Trp Glu Val Phe Arg Val Ser Ser Asp Lys 
65                  70                  75                  80  


Leu Ala Leu Cys His Leu Glu Leu Thr Arg Lys Leu Gln Asp Leu Ile 
                85                  90                  95      


Lys Asp Val Leu Arg Tyr Gly Glu Glu Gln Leu Lys Thr His Lys Lys 
            100                 105                 110         


Cys Lys Glu Glu Val Val Ser Thr Leu Asp Ala Val Gln Val Leu Ser 
        115                 120                 125             


Gly Val Ser Gln Leu Leu Pro Lys Ser Arg Glu Asn Tyr Leu Asn Arg 
    130                 135                 140                 


Cys Met Asp Gln Glu Arg Leu Arg Arg Glu Ser Thr Ser Gln Lys Glu 
145                 150                 155                 160 


Met Asp Lys Ala Glu Thr Lys Thr Lys Lys Ala Ala Glu Ser Leu Arg 
                165                 170                 175     


Arg Ser Val Glu Lys Tyr Asn Ser Ala Arg Ala Asp Phe Glu Gln Lys 
            180                 185                 190         


Met Leu Asp Ser Ala Leu Arg Phe Gln Ala Met Glu Glu Thr His Leu 
        195                 200                 205             


Arg His Met Lys Ala Leu Leu Gly Ser Tyr Ala His Ser Val Glu Asp 
    210                 215                 220                 


Thr His Val Gln Ile Gly Gln Val His Glu Glu Phe Lys Gln Asn Ile 
225                 230                 235                 240 


Glu Asn Val Ser Val Glu Met Leu Leu Arg Lys Phe Ala Glu Ser Lys 
                245                 250                 255     


Gly Thr Gly Arg Glu Lys Pro Gly Pro Leu Asp Phe Glu Ala Tyr Ser 
            260                 265                 270         


Ala Ala Ala Leu Gln Glu Ala Met Lys Arg Leu Arg Gly Ala Lys Ala 
        275                 280                 285             


Phe Arg Leu Pro Gly Leu Ser Arg Arg Glu Arg Glu Pro Glu Pro Pro 
    290                 295                 300                 


Ala Ala Val Asp Phe Leu Glu Pro Asp Ser Gly Thr Cys Pro Glu Val 
305                 310                 315                 320 


Asp Glu Glu Gly Phe Thr Val Arg Pro Asp Val Thr Gln Asn Ser Thr 
                325                 330                 335     


Ala Glu Pro Ser Arg Phe Ser Ser Ser Asp Ser Asp Phe Asp Asp Glu 
            340                 345                 350         


Glu Pro Arg Lys Phe Tyr Val His Ile Lys Pro Ala Pro Ala Arg Ala 
        355                 360                 365             


Pro Ala Cys Ser Pro Glu Ala Ala Ala Ala Gln Leu Arg Ala Thr Ala 
    370                 375                 380                 


Gly Ser Leu Ile Leu Pro Pro Gly Pro Gly Gly Thr Met Lys Arg His 
385                 390                 395                 400 


Ser Ser Arg Asp Ala Ala Gly Lys Pro Gln Arg Pro Arg Ser Ala Pro 
                405                 410                 415     


Arg Thr Ser Ser Cys Ala Glu Arg Leu Gln Ser Glu Glu Gln Val Ser 
            420                 425                 430         


Lys Asn Leu Phe Gly Pro Pro Leu Glu Ser Ala Phe Asp His Glu Asp 
        435                 440                 445             


Phe Thr Gly Ser Ser Ser Leu Gly Phe Thr Ser Ser Pro Ser Pro Phe 
    450                 455                 460                 


Ser Ser Ser Ser Pro Glu Asn Val Glu Asp Ser Gly Leu Asp Ser Pro 
465                 470                 475                 480 


Ser His Ala Ala Pro Gly Pro Ser Pro Asp Ser Trp Val Pro Arg Pro 
                485                 490                 495     


Gly Thr Pro Gln Ser Pro Pro Ser Cys Arg Ala Pro Pro Pro Glu Ala 
            500                 505                 510         


Arg Gly Ile Arg Ala Pro Pro Leu Pro Asp Ser Pro Gln Pro Leu Ala 
        515                 520                 525             


Ser Ser Pro Gly Pro Trp Gly Leu Glu Ala Leu Ala Gly Gly Asp Leu 
    530                 535                 540                 


Met Pro Ala Pro Ala Asp Pro Thr Ala Arg Glu Gly Leu Ala Ala Pro 
545                 550                 555                 560 


Pro Arg Arg Leu Arg Ser Arg Lys Val Ser Cys Pro Leu Thr Arg Ser 
                565                 570                 575     


Asn Gly Asp Leu Ser Arg Ser Leu Ser Pro Ser Pro Leu Gly Ser Ser 
            580                 585                 590         


Ala Ala Ser Thr Ala Leu Glu Arg Pro Ser Phe Leu Ser Gln Thr Gly 
        595                 600                 605             


His Gly Val Ser Arg Gly Pro Ser Pro Val Val Leu Gly Ser Gln Asp 
    610                 615                 620                 


Ala Leu Pro Ile Ala Thr Ala Phe Thr Glu Tyr Val His Ala Tyr Phe 
625                 630                 635                 640 


Arg Gly His Ser Pro Ser Cys Leu Ala Arg Val Thr Gly Glu Leu Thr 
                645                 650                 655     


Met Thr Phe Pro Ala Gly Ile Val Arg Val Phe Ser Gly Thr Pro Pro 
            660                 665                 670         


Pro Pro Val Leu Ser Phe Arg Leu Val His Thr Thr Ala Ile Glu His 
        675                 680                 685             


Phe Gln Pro Asn Ala Asp Leu Leu Phe Ser Asp Pro Ser Gln Ser Asp 
    690                 695                 700                 


Pro Glu Thr Lys Asp Phe Trp Leu Asn Met Ala Ala Leu Thr Glu Ala 
705                 710                 715                 720 


Leu Gln Arg Gln Ala Glu Gln Asn Pro Thr Ala Ser Tyr Tyr Asn Val 
                725                 730                 735     


Val Leu Leu Arg Tyr Gln Phe Ser Arg Pro Gly Pro Gln Ser Val Pro 
            740                 745                 750         


Leu Gln Leu Ser Ala His Trp Gln Cys Gly Ala Thr Leu Thr Gln Val 
        755                 760                 765             


Ser Val Glu Tyr Gly Tyr Arg Pro Gly Ala Thr Ala Val Pro Thr Pro 
    770                 775                 780                 


Leu Thr Asn Val Gln Ile Leu Leu Pro Val Gly Glu Pro Val Thr Asn 
785                 790                 795                 800 


Val Arg Leu Gln Pro Ala Ala Thr Trp Asn Leu Glu Glu Lys Arg Leu 
                805                 810                 815     


Thr Trp Arg Leu Pro Asp Val Ser Glu Ala Gly Gly Ser Gly Arg Leu 
            820                 825                 830         


Ser Ala Ser Trp Glu Pro Leu Ser Gly Pro Ser Thr Pro Ser Pro Val 
        835                 840                 845             


Ala Ala Gln Phe Thr Ser Glu Gly Thr Thr Leu Ser Gly Val Asp Leu 
    850                 855                 860                 


Glu Leu Val Gly Ser Gly Tyr Arg Met Ser Leu Val Lys Arg Arg Phe 
865                 870                 875                 880 


Ala Thr Ala Ala Pro Pro Gln Gly Cys Thr Trp 
                885                 890     


<210>  3965
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCHO2__Homo_sapiens__NP_001139504

<400>  3965

Met Val Met Ala Tyr Phe Val Glu Asn Phe Trp Gly Glu Lys Asn Ser 
1               5                   10                  15      


Gly Phe Asp Val Leu Tyr His Asn Met Lys His Gly Gln Ile Ser Thr 
            20                  25                  30          


Lys Glu Leu Ala Asp Phe Val Arg Glu Arg Ala Thr Ile Glu Glu Ala 
        35                  40                  45              


Tyr Ser Arg Ser Met Thr Lys Leu Ala Lys Ser Ala Ser Asn Tyr Ser 
    50                  55                  60                  


Gln Leu Gly Thr Phe Ala Pro Val Trp Asp Val Phe Lys Thr Ser Thr 
65                  70                  75                  80  


Glu Lys Leu Ala Asn Cys His Leu Asp Leu Val Arg Lys Leu Gln Glu 
                85                  90                  95      


Leu Ile Lys Glu Val Gln Lys Tyr Gly Glu Glu Gln Val Lys Ser His 
            100                 105                 110         


Lys Lys Thr Lys Glu Glu Val Ala Gly Thr Leu Glu Ala Val Gln Thr 
        115                 120                 125             


Ile Gln Ser Ile Thr Gln Ala Leu Gln Lys Ser Lys Glu Asn Tyr Asn 
    130                 135                 140                 


Ala Lys Cys Val Glu Gln Glu Arg Leu Lys Lys Glu Gly Ala Thr Gln 
145                 150                 155                 160 


Arg Glu Ile Glu Lys Ala Ala Val Lys Ser Lys Lys Ala Thr Asp Thr 
                165                 170                 175     


Tyr Lys Leu Tyr Val Glu Lys Tyr Ala Leu Ala Lys Ala Asp Phe Glu 
            180                 185                 190         


Gln Lys Met Thr Glu Thr Ala Gln Val His Glu Glu Phe Ile Asn Asn 
        195                 200                 205             


Met Ala Asn Thr Thr Val Glu Ser Leu Ile Gln Lys Phe Ala Glu Ser 
    210                 215                 220                 


Lys Gly Thr Gly Lys Glu Arg Pro Gly Leu Ile Glu Phe Glu Glu Cys 
225                 230                 235                 240 


Asp Thr Ala Ser Ala Val Glu Gly Ile Lys Pro Arg Lys Arg Lys Thr 
                245                 250                 255     


Phe Ala Leu Pro Gly Ile Ile Lys Lys Glu Lys Asp Ala Glu Ser Val 
            260                 265                 270         


Glu Cys Pro Asp Ala Asp Ser Leu Asn Ile Pro Asp Val Asp Glu Glu 
        275                 280                 285             


Gly Tyr Ser Ile Lys Pro Glu Thr Asn Gln Asn Asp Thr Lys Glu Asn 
    290                 295                 300                 


His Phe Tyr Ser Ser Ser Asp Ser Asp Ser Glu Asp Glu Glu Pro Lys 
305                 310                 315                 320 


Lys Tyr Arg Ile Glu Ile Lys Pro Met His Pro Asn Asn Ser His His 
                325                 330                 335     


Thr Met Ala Ser Leu Asp Glu Leu Lys Val Ser Ile Gly Asn Ile Thr 
            340                 345                 350         


Leu Ser Pro Ala Ile Ser Arg His Ser Pro Val Gln Met Asn Arg Asn 
        355                 360                 365             


Leu Ser Asn Glu Glu Leu Thr Lys Ser Lys Pro Ser Ala Pro Pro Asn 
    370                 375                 380                 


Glu Lys Gly Thr Ser Asp Leu Leu Ala Trp Asp Pro Leu Phe Gly Pro 
385                 390                 395                 400 


Ser Leu Asp Ser Ser Ser Ser Ser Ser Leu Thr Ser Ser Ser Ser Ala 
                405                 410                 415     


Arg Pro Thr Thr Pro Leu Ser Val Gly Thr Ile Val Pro Pro Pro Arg 
            420                 425                 430         


Pro Ala Ser Arg Pro Lys Leu Thr Ser Gly Lys Leu Ser Gly Ile Asn 
        435                 440                 445             


Glu Ile Pro Arg Pro Phe Ser Pro Pro Val Thr Ser Asn Thr Ser Pro 
    450                 455                 460                 


Pro Pro Ala Ala Pro Leu Ala Arg Ala Glu Ser Ser Ser Ser Ile Ser 
465                 470                 475                 480 


Ser Ser Ala Ser Leu Ser Ala Ala Asn Thr Pro Thr Val Gly Val Ser 
                485                 490                 495     


Arg Gly Pro Ser Pro Val Ser Leu Gly Asn Gln Asp Thr Leu Pro Val 
            500                 505                 510         


Ala Val Ala Leu Thr Glu Ser Val Asn Ala Tyr Phe Lys Gly Ala Asp 
        515                 520                 525             


Pro Thr Lys Cys Ile Val Lys Ile Thr Gly Asp Met Thr Met Ser Phe 
    530                 535                 540                 


Pro Ser Gly Ile Ile Lys Val Phe Thr Ser Asn Pro Thr Pro Ala Val 
545                 550                 555                 560 


Leu Cys Phe Arg Val Lys Asn Ile Ser Arg Leu Glu Gln Ile Leu Pro 
                565                 570                 575     


Asn Ala Gln Leu Val Phe Ser Asp Pro Ser Gln Cys Asp Ser Asn Thr 
            580                 585                 590         


Lys Asp Phe Trp Met Asn Met Gln Ala Val Thr Val Tyr Leu Lys Lys 
        595                 600                 605             


Leu Ser Glu Gln Asn Pro Ala Ala Ser Tyr Tyr Asn Val Asp Val Leu 
    610                 615                 620                 


Lys Tyr Gln Val Ser Ser Asn Gly Ile Gln Ser Thr Pro Leu Asn Leu 
625                 630                 635                 640 


Ala Thr Tyr Trp Lys Cys Ser Ala Ser Thr Thr Asp Leu Arg Val Asp 
                645                 650                 655     


Tyr Lys Tyr Asn Pro Glu Ala Met Val Ala Pro Ser Val Leu Ser Asn 
            660                 665                 670         


Ile Gln Val Val Val Pro Val Asp Gly Gly Val Thr Asn Met Gln Ser 
        675                 680                 685             


Leu Pro Pro Ala Ile Trp Asn Ala Glu Gln Met Lys Ala Phe Trp Lys 
    690                 695                 700                 


Leu Ser Ser Ile Ser Glu Lys Ser Glu Asn Gly Gly Ser Gly Ser Leu 
705                 710                 715                 720 


Arg Ala Lys Phe Asp Leu Ser Glu Gly Pro Ser Lys Pro Thr Thr Leu 
                725                 730                 735     


Ala Val Gln Phe Leu Ser Glu Gly Ser Thr Leu Ser Gly Val Asp Phe 
            740                 745                 750         


Glu Leu Val Gly Thr Gly Tyr Arg Leu Ser Leu Ile Lys Lys Arg Phe 
        755                 760                 765             


Ala Thr Gly Arg Tyr Leu Ala Asp Cys 
    770                 775         


<210>  3966
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCHSD2__Homo_sapiens__NP_055639

<400>  3966

Met Gln Pro Pro Pro Arg Lys Val Lys Val Thr Gln Glu Leu Lys Asn 
1               5                   10                  15      


Ile Gln Val Glu Gln Met Thr Lys Leu Gln Ala Lys His Gln Ala Glu 
            20                  25                  30          


Cys Asp Leu Leu Glu Asp Met Arg Thr Phe Ser Gln Lys Lys Ala Ala 
        35                  40                  45              


Ile Glu Arg Glu Tyr Ala Gln Gly Met Gln Lys Leu Ala Ser Gln Tyr 
    50                  55                  60                  


Leu Lys Arg Asp Trp Pro Gly Val Lys Ala Asp Asp Arg Asn Asp Tyr 
65                  70                  75                  80  


Arg Ser Met Tyr Pro Val Trp Lys Ser Phe Leu Glu Gly Thr Met Gln 
                85                  90                  95      


Val Ala Gln Ser Arg Met Asn Ile Cys Glu Asn Tyr Lys Asn Phe Ile 
            100                 105                 110         


Ser Glu Pro Ala Arg Thr Val Arg Ser Leu Lys Glu Gln Gln Leu Lys 
        115                 120                 125             


Arg Cys Val Asp Gln Leu Thr Lys Ile Gln Thr Glu Leu Gln Glu Thr 
    130                 135                 140                 


Val Lys Asp Leu Ala Lys Gly Lys Lys Lys Tyr Phe Glu Thr Glu Gln 
145                 150                 155                 160 


Met Ala His Ala Val Arg Glu Lys Ala Asp Ile Glu Ala Lys Ser Lys 
                165                 170                 175     


Leu Ser Leu Phe Gln Ser Arg Ile Ser Leu Gln Lys Ala Ser Val Lys 
            180                 185                 190         


Leu Lys Ala Arg Arg Ser Glu Cys Asn Ser Lys Ala Thr His Ala Arg 
        195                 200                 205             


Asn Asp Tyr Leu Leu Thr Leu Ala Ala Ala Asn Ala His Gln Asp Arg 
    210                 215                 220                 


Tyr Tyr Gln Thr Asp Leu Val Asn Ile Met Lys Ala Leu Asp Gly Asn 
225                 230                 235                 240 


Val Tyr Asp His Leu Lys Asp Tyr Leu Ile Ala Phe Ser Arg Thr Glu 
                245                 250                 255     


Leu Glu Thr Cys Gln Ala Val Gln Asn Thr Phe Gln Phe Leu Leu Glu 
            260                 265                 270         


Asn Ser Ser Lys Val Val Arg Asp Tyr Asn Leu Gln Leu Phe Leu Gln 
        275                 280                 285             


Glu Asn Ala Val Phe His Lys Pro Gln Pro Phe Gln Phe Gln Pro Cys 
    290                 295                 300                 


Asp Ser Asp Thr Ser Arg Gln Leu Glu Ser Glu Thr Gly Thr Thr Glu 
305                 310                 315                 320 


Glu His Ser Leu Asn Lys Glu Ala Arg Lys Trp Ala Thr Arg Val Ala 
                325                 330                 335     


Arg Glu His Lys Asn Ile Val His Gln Gln Arg Val Leu Asn Asp Leu 
            340                 345                 350         


Glu Cys His Gly Ala Ala Val Ser Glu Gln Ser Arg Ala Glu Leu Glu 
        355                 360                 365             


Gln Lys Ile Asp Glu Ala Arg Glu Asn Ile Arg Lys Ala Glu Ile Ile 
    370                 375                 380                 


Lys Leu Lys Ala Glu Ala Arg Leu Asp Leu Leu Lys Gln Ile Gly Val 
385                 390                 395                 400 


Ser Val Asp Thr Trp Leu Lys Ser Ala Met Asn Gln Val Met Glu Glu 
                405                 410                 415     


Leu Glu Asn Glu Arg Trp Ala Arg Pro Pro Ala Val Thr Ser Asn Gly 
            420                 425                 430         


Thr Leu His Ser Leu Asn Ala Asp Thr Glu Arg Glu Glu Gly Glu Glu 
        435                 440                 445             


Phe Glu Asp Asn Met Asp Val Phe Asp Asp Ser Ser Ser Ser Pro Ser 
    450                 455                 460                 


Gly Thr Leu Arg Asn Tyr Pro Leu Thr Cys Lys Val Val Tyr Ser Tyr 
465                 470                 475                 480 


Lys Ala Ser Gln Pro Asp Glu Leu Thr Ile Glu Glu His Glu Val Leu 
                485                 490                 495     


Glu Val Ile Glu Asp Gly Asp Met Glu Asp Trp Val Lys Ala Arg Asn 
            500                 505                 510         


Lys Val Gly Gln Val Gly Tyr Val Pro Glu Lys Tyr Leu Gln Phe Pro 
        515                 520                 525             


Thr Ser Asn Ser Leu Leu Ser Met Leu Gln Ser Leu Ala Ala Leu Asp 
    530                 535                 540                 


Ser Arg Ser His Thr Ser Ser Asn Ser Thr Glu Ala Glu Leu Val Ser 
545                 550                 555                 560 


Gly Ser Leu Asn Gly Asp Ala Ser Val Cys Phe Val Lys Ala Leu Tyr 
                565                 570                 575     


Asp Tyr Glu Gly Gln Thr Asp Asp Glu Leu Ser Phe Pro Glu Gly Ala 
            580                 585                 590         


Ile Ile Arg Ile Leu Asn Lys Glu Asn Gln Asp Asp Asp Gly Phe Trp 
        595                 600                 605             


Glu Gly Glu Phe Asn Gly Arg Ile Gly Val Phe Pro Ser Val Leu Val 
    610                 615                 620                 


Glu Glu Leu Ser Ala Ser Glu Asn Gly Asp Thr Pro Trp Met Arg Glu 
625                 630                 635                 640 


Ile Gln Ile Ser Pro Ser Pro Lys Pro His Ala Ser Leu Pro Pro Leu 
                645                 650                 655     


Pro Leu Tyr Asp Gln Pro Pro Ser Ser Pro Tyr Pro Ser Pro Asp Lys 
            660                 665                 670         


Arg Ser Ser Leu Tyr Phe Pro Arg Ser Pro Ser Ala Asn Glu Lys Ser 
        675                 680                 685             


Leu His Ala Glu Ser Pro Gly Phe Ser Gln Ala Ser Arg His Thr Pro 
    690                 695                 700                 


Glu Thr Ser Tyr Gly Lys Leu Arg Pro Val Arg Ala Ala Pro Pro Pro 
705                 710                 715                 720 


Pro Thr Gln Asn His Arg Arg Pro Ala Glu Lys Ile Glu Asp Val Glu 
                725                 730                 735     


Ile Thr Leu Val 
            740 


<210>  3967
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCN1__Homo_sapiens__NP_001994

<400>  3967

Met Glu Leu Ser Gly Ala Thr Met Ala Arg Gly Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Leu Phe Leu His Ile Lys Asn Leu Pro Ala Gln Ala Ala Asp Thr 
            20                  25                  30          


Cys Pro Glu Val Lys Val Val Gly Leu Glu Gly Ser Asp Lys Leu Thr 
        35                  40                  45              


Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly 
    50                  55                  60                  


Glu Ala Gly Val Ile Gly Glu Arg Gly Glu Arg Gly Leu Pro Gly Ala 
65                  70                  75                  80  


Pro Gly Lys Ala Gly Pro Val Gly Pro Lys Gly Asp Arg Gly Glu Lys 
                85                  90                  95      


Gly Met Arg Gly Glu Lys Gly Asp Ala Gly Gln Ser Gln Ser Cys Ala 
            100                 105                 110         


Thr Gly Pro Arg Asn Cys Lys Asp Leu Leu Asp Arg Gly Tyr Phe Leu 
        115                 120                 125             


Ser Gly Trp His Thr Ile Tyr Leu Pro Asp Cys Arg Pro Leu Thr Val 
    130                 135                 140                 


Leu Cys Asp Met Asp Thr Asp Gly Gly Gly Trp Thr Val Phe Gln Arg 
145                 150                 155                 160 


Arg Met Asp Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala Ala Tyr Lys 
                165                 170                 175     


Gln Gly Phe Gly Ser Gln Leu Gly Glu Phe Trp Leu Gly Asn Asp Asn 
            180                 185                 190         


Ile His Ala Leu Thr Ala Gln Gly Ser Ser Glu Leu Arg Val Asp Leu 
        195                 200                 205             


Val Asp Phe Glu Gly Asn His Gln Phe Ala Lys Tyr Lys Ser Phe Lys 
    210                 215                 220                 


Val Ala Asp Glu Ala Glu Lys Tyr Lys Leu Val Leu Gly Ala Phe Val 
225                 230                 235                 240 


Gly Gly Ser Ala Gly Asn Ser Leu Thr Gly His Asn Asn Asn Phe Phe 
                245                 250                 255     


Ser Thr Lys Asp Gln Asp Asn Asp Val Ser Ser Ser Asn Cys Ala Glu 
            260                 265                 270         


Lys Phe Gln Gly Ala Trp Trp Tyr Ala Asp Cys His Ala Ser Asn Leu 
        275                 280                 285             


Asn Gly Leu Tyr Leu Met Gly Pro His Glu Ser Tyr Ala Asn Gly Ile 
    290                 295                 300                 


Asn Trp Ser Ala Ala Lys Gly Tyr Lys Tyr Ser Tyr Lys Val Ser Glu 
305                 310                 315                 320 


Met Lys Val Arg Pro Ala 
                325     


<210>  3968
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCN2__Homo_sapiens__NP_004099

<400>  3968

Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala Asp Thr Cys 
            20                  25                  30          


Pro Glu Val Lys Met Val Gly Leu Glu Gly Ser Asp Lys Leu Thr Ile 
        35                  40                  45              


Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly Glu 
    50                  55                  60                  


Ala Gly Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Pro Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Ala Gly Pro Pro Gly Pro Asn Gly Ala Pro Gly Glu Pro Gln 
                85                  90                  95      


Pro Cys Leu Thr Gly Pro Arg Thr Cys Lys Asp Leu Leu Asp Arg Gly 
            100                 105                 110         


His Phe Leu Ser Gly Trp His Thr Ile Tyr Leu Pro Asp Cys Arg Pro 
        115                 120                 125             


Leu Thr Val Leu Cys Asp Met Asp Thr Asp Gly Gly Gly Trp Thr Val 
    130                 135                 140                 


Phe Gln Arg Arg Val Asp Gly Ser Val Asp Phe Tyr Arg Asp Trp Ala 
145                 150                 155                 160 


Thr Tyr Lys Gln Gly Phe Gly Ser Arg Leu Gly Glu Phe Trp Leu Gly 
                165                 170                 175     


Asn Asp Asn Ile His Ala Leu Thr Ala Gln Gly Thr Ser Glu Leu Arg 
            180                 185                 190         


Val Asp Leu Val Asp Phe Glu Asp Asn Tyr Gln Phe Ala Lys Tyr Arg 
        195                 200                 205             


Ser Phe Lys Val Ala Asp Glu Ala Glu Lys Tyr Asn Leu Val Leu Gly 
    210                 215                 220                 


Ala Phe Val Glu Gly Ser Ala Gly Asp Ser Leu Thr Phe His Asn Asn 
225                 230                 235                 240 


Gln Ser Phe Ser Thr Lys Asp Gln Asp Asn Asp Leu Asn Thr Gly Asn 
                245                 250                 255     


Cys Ala Val Met Phe Gln Gly Ala Trp Trp Tyr Lys Asn Cys His Val 
            260                 265                 270         


Ser Asn Leu Asn Gly Arg Tyr Leu Arg Gly Thr His Gly Ser Phe Ala 
        275                 280                 285             


Asn Gly Ile Asn Trp Lys Ser Gly Lys Gly Tyr Asn Tyr Ser Tyr Lys 
    290                 295                 300                 


Val Ser Glu Met Lys Val Arg Pro Ala 
305                 310             


<210>  3969
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRL1__Homo_sapiens__NP_001152869

<400>  3969

Met Leu Pro Arg Leu Leu Leu Leu Ile Cys Ala Pro Leu Cys Glu Pro 
1               5                   10                  15      


Ala Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu Gly Ser 
            20                  25                  30          


Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser Asp Ala 
        35                  40                  45              


Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly Pro Gly 
    50                  55                  60                  


Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys Glu Asp 
65                  70                  75                  80  


Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys Val Leu 
                85                  90                  95      


Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val Ala Asp 
            100                 105                 110         


Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu Gly Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp Ile Thr 
    130                 135                 140                 


Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser Lys Thr 
145                 150                 155                 160 


Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg Glu Ser 
                165                 170                 175     


Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly Pro Ser 
            180                 185                 190         


Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser Arg Pro 
        195                 200                 205             


Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu Asp Val 
    210                 215                 220                 


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr 
225                 230                 235                 240 


Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala Pro Ser 
                245                 250                 255     


Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His Ser Gly 
            260                 265                 270         


Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg Ser Glu 
        275                 280                 285             


Ala Val Thr Leu Asn Phe Thr Gly Arg Arg Ser Ala Arg Asp Pro Leu 
    290                 295                 300                 


Arg Ser Leu Pro Ser Pro Leu Pro Gln Glu Phe Thr Tyr Leu Asn Ser 
305                 310                 315                 320 


Pro Thr Pro Gly Gln Leu Gln Pro Ile Tyr Glu Asn Glu Pro Arg Glu 
                325                 330                 335     


Gln Ser Val Ala Val His Gly Arg Gln Gln His Ser Ser Glu Gln Lys 
            340                 345                 350         


Ala Gln Lys Pro Trp Gly His Ile Trp Arg Thr Arg Phe Pro 
        355                 360                 365     


<210>  3970
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRL2__Homo_sapiens__NP_001152960

<400>  3970

Met Leu Leu Trp Ser Leu Leu Val Ile Phe Asp Ala Val Thr Glu Gln 
1               5                   10                  15      


Ala Asp Ser Leu Thr Leu Val Ala Pro Ser Ser Val Phe Glu Gly Asp 
            20                  25                  30          


Ser Ile Val Leu Lys Cys Gln Gly Glu Gln Asn Trp Lys Ile Gln Lys 
        35                  40                  45              


Met Ala Tyr His Lys Asp Asn Lys Glu Leu Ser Val Phe Lys Lys Phe 
    50                  55                  60                  


Ser Asp Phe Leu Ile Gln Ser Ala Val Leu Ser Asp Ser Gly Asn Tyr 
65                  70                  75                  80  


Phe Cys Ser Thr Lys Gly Gln Leu Phe Leu Trp Asp Lys Thr Ser Asn 
                85                  90                  95      


Ile Val Lys Ile Lys Val Gln Glu Leu Phe Gln Arg Pro Val Leu Thr 
            100                 105                 110         


Ala Ser Ser Phe Gln Pro Ile Glu Gly Gly Pro Val Ser Leu Lys Cys 
        115                 120                 125             


Glu Thr Arg Leu Ser Pro Gln Arg Leu Asp Val Gln Leu Gln Phe Cys 
    130                 135                 140                 


Phe Phe Arg Glu Asn Gln Val Leu Gly Ser Gly Trp Ser Ser Ser Pro 
145                 150                 155                 160 


Glu Leu Gln Ile Ser Ala Val Trp Ser Glu Asp Thr Gly Ser Tyr Trp 
                165                 170                 175     


Cys Lys Ala Glu Thr Val Thr His Arg Ile Arg Lys Gln Ser Leu Gln 
            180                 185                 190         


Ser Gln Ile His Val Gln Arg Ile Pro Ile Ser Asn Val Ser Leu Glu 
        195                 200                 205             


Ile Arg Ala Pro Gly Gly Gln Val Thr Glu Gly Gln Lys Leu Ile Leu 
    210                 215                 220                 


Leu Cys Ser Val Ala Gly Gly Thr Gly Asn Val Thr Phe Ser Trp Tyr 
225                 230                 235                 240 


Arg Glu Ala Thr Gly Thr Ser Met Gly Lys Lys Thr Gln Arg Ser Leu 
                245                 250                 255     


Ser Ala Glu Leu Glu Ile Pro Ala Val Lys Glu Ser Asp Ala Gly Lys 
            260                 265                 270         


Tyr Tyr Cys Arg Ala Asp Asn Gly His Val Pro Ile Gln Ser Lys Val 
        275                 280                 285             


Val Asn Ile Pro Val Arg Ile Pro Val Ser Arg Pro Val Leu Thr Leu 
    290                 295                 300                 


Arg Ser Pro Gly Ala Gln Ala Ala Val Gly Asp Leu Leu Glu Leu His 
305                 310                 315                 320 


Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile Leu Tyr Gln Phe Tyr His 
                325                 330                 335     


Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly Gly Gly Ala 
            340                 345                 350         


Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Ser Cys 
        355                 360                 365             


Glu Ala Asn Asn Gly Leu Gly Ala Gln Cys Ser Glu Ala Val Pro Val 
    370                 375                 380                 


Ser Ile Ser Gly Pro Asp Gly Tyr Arg Arg Asp Leu Met Thr Ala Gly 
385                 390                 395                 400 


Val Leu Trp Gly Leu Phe Gly Val Leu Gly Phe Thr Gly Val Ala Leu 
                405                 410                 415     


Leu Leu Tyr Ala Leu Phe His Lys Ile Ser Gly Glu Ser Ser Ala Thr 
            420                 425                 430         


Asn Glu Pro Arg Thr Pro Lys Ser Ser Thr Leu Leu 
        435                 440                 


<210>  3971
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRL3__Homo_sapiens__XP_006711208

<400>  3971

Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln 
1               5                   10                  15      


Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser 
            20                  25                  30          


Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser 
        35                  40                  45              


His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu 
    50                  55                  60                  


Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr 
65                  70                  75                  80  


Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu 
                85                  90                  95      


Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu 
            100                 105                 110         


Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr 
        115                 120                 125             


His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr 
    130                 135                 140                 


Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys 
145                 150                 155                 160 


Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val 
                165                 170                 175     


Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Glu Leu Phe Leu His Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Ser Thr Pro Ile Glu Gly Ser Pro Met Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Pro Gln Arg Pro Asp Val Gln Leu 
    210                 215                 220                 


Gln Phe Ser Leu Phe Arg Asp Ser Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Arg Ser Pro Arg Leu Gln Ile Pro Ala Met Trp Thr Glu Asp Ser Gly 
                245                 250                 255     


Ser Tyr Trp Cys Glu Val Glu Thr Val Thr His Ser Ile Lys Lys Arg 
            260                 265                 270         


Ser Leu Arg Ser Gln Ile Arg Val Gln Arg Val Pro Val Ser Asn Val 
        275                 280                 285             


Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu Asn 
    290                 295                 300                 


Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr Phe 
305                 310                 315                 320 


Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr Gln 
                325                 330                 335     


Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser Asp 
            340                 345                 350         


Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile Leu 
        355                 360                 365             


Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro Val 
    370                 375                 380                 


Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu Leu 
385                 390                 395                 400 


Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr Arg 
                405                 410                 415     


Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser Gly 
            420                 425                 430         


Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
        435                 440                 445             


Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His Gly 
    450                 455                 460                 


Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr Leu 
465                 470                 475                 480 


Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu His 
                485                 490                 495     


Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr His 
            500                 505                 510         


Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly Ala 
        515                 520                 525             


Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser Cys 
    530                 535                 540                 


Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr Leu 
545                 550                 555                 560 


Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala Gly 
                565                 570                 575     


Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala Ala 
            580                 585                 590         


Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser Ala 
        595                 600                 605             


Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser Ser 
    610                 615                 620                 


Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys Pro 
625                 630                 635                 640 


Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro Gly 
                645                 650                 655     


Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr Lys 
            660                 665                 670         


Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu Leu 
        675                 680                 685             


Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser Ala 
    690                 695                 700                 


Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu Glu 
705                 710                 715                 720 


Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His 
                725                 730                 


<210>  3972
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRL4__Homo_sapiens__NP_112572

<400>  3972

Met Leu Leu Trp Ala Ser Leu Leu Ala Phe Ala Pro Val Cys Gly Gln 
1               5                   10                  15      


Ser Ala Ala Ala His Lys Pro Val Ile Ser Val His Pro Pro Trp Thr 
            20                  25                  30          


Thr Phe Phe Lys Gly Glu Arg Val Thr Leu Thr Cys Asn Gly Phe Gln 
        35                  40                  45              


Phe Tyr Ala Thr Glu Lys Thr Thr Trp Tyr His Arg His Tyr Trp Gly 
    50                  55                  60                  


Glu Lys Leu Thr Leu Thr Pro Gly Asn Thr Leu Glu Val Arg Glu Ser 
65                  70                  75                  80  


Gly Leu Tyr Arg Cys Gln Ala Arg Gly Ser Pro Arg Ser Asn Pro Val 
                85                  90                  95      


Arg Leu Leu Phe Ser Ser Asp Ser Leu Ile Leu Gln Ala Pro Tyr Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Thr Leu Val Leu Arg Cys His Arg Arg Arg Lys 
        115                 120                 125             


Glu Lys Leu Thr Ala Val Lys Tyr Thr Trp Asn Gly Asn Ile Leu Ser 
    130                 135                 140                 


Ile Ser Asn Lys Ser Trp Asp Leu Leu Ile Pro Gln Ala Ser Ser Asn 
145                 150                 155                 160 


Asn Asn Gly Asn Tyr Arg Cys Ile Gly Tyr Gly Asp Glu Asn Asp Val 
                165                 170                 175     


Phe Arg Ser Asn Phe Lys Ile Ile Lys Ile Gln Glu Leu Phe Pro His 
            180                 185                 190         


Pro Glu Leu Lys Ala Thr Asp Ser Gln Pro Thr Glu Gly Asn Ser Val 
        195                 200                 205             


Asn Leu Ser Cys Glu Thr Gln Leu Pro Pro Glu Arg Ser Asp Thr Pro 
    210                 215                 220                 


Leu His Phe Asn Phe Phe Arg Asp Gly Glu Val Ile Leu Ser Asp Trp 
225                 230                 235                 240 


Ser Thr Tyr Pro Glu Leu Gln Leu Pro Thr Val Trp Arg Glu Asn Ser 
                245                 250                 255     


Gly Ser Tyr Trp Cys Gly Ala Glu Thr Val Arg Gly Asn Ile His Lys 
            260                 265                 270         


His Ser Pro Ser Leu Gln Ile His Val Gln Arg Ile Pro Val Ser Gly 
        275                 280                 285             


Val Leu Leu Glu Thr Gln Pro Ser Gly Gly Gln Ala Val Glu Gly Glu 
    290                 295                 300                 


Met Leu Val Leu Val Cys Ser Val Ala Glu Gly Thr Gly Asp Thr Thr 
305                 310                 315                 320 


Phe Ser Trp His Arg Glu Asp Met Gln Glu Ser Leu Gly Arg Lys Thr 
                325                 330                 335     


Gln Arg Ser Leu Arg Ala Glu Leu Glu Leu Pro Ala Ile Arg Gln Ser 
            340                 345                 350         


His Ala Gly Gly Tyr Tyr Cys Thr Ala Asp Asn Ser Tyr Gly Pro Val 
        355                 360                 365             


Gln Ser Met Val Leu Asn Val Thr Val Arg Glu Thr Pro Gly Asn Arg 
    370                 375                 380                 


Asp Gly Leu Val Ala Ala Gly Ala Thr Gly Gly Leu Leu Ser Ala Leu 
385                 390                 395                 400 


Leu Leu Ala Val Ala Leu Leu Phe His Cys Trp Arg Arg Arg Lys Ser 
                405                 410                 415     


Gly Val Gly Phe Leu Gly Asp Glu Thr Arg Leu Pro Pro Ala Pro Gly 
            420                 425                 430         


Pro Gly Glu Ser Ser His Ser Ile Cys Pro Ala Gln Val Glu Leu Gln 
        435                 440                 445             


Ser Leu Tyr Val Asp Val His Pro Lys Lys Gly Asp Leu Val Tyr Ser 
    450                 455                 460                 


Glu Ile Gln Thr Thr Gln Leu Gly Glu Glu Glu Glu Ala Asn Thr Ser 
465                 470                 475                 480 


Arg Thr Leu Leu Glu Asp Lys Asp Val Ser Val Val Tyr Ser Glu Val 
                485                 490                 495     


Lys Thr Gln His Pro Asp Asn Ser Ala Gly Lys Ile Ser Ser Lys Asp 
            500                 505                 510         


Glu Glu Ser 
        515 


<210>  3973
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRL5__Homo_sapiens__NP_112571

<400>  3973

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg Pro 
            740                 745                 750         


Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp Leu 
        755                 760                 765             


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr 
    770                 775                 780                 


Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser 
785                 790                 795                 800 


Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
                805                 810                 815     


Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr 
            820                 825                 830         


Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe 
        835                 840                 845             


Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala 
    850                 855                 860                 


Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys 
865                 870                 875                 880 


Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu 
                885                 890                 895     


Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr 
            900                 905                 910         


Thr Asn Ala Asn Pro Arg Gly Glu Asn Val Val Tyr Ser Glu Val Arg 
        915                 920                 925             


Ile Ile Gln Glu Lys Lys Lys His Ala Val Ala Ser Asp Pro Arg His 
    930                 935                 940                 


Leu Arg Asn Lys Gly Ser Pro Ile Ile Tyr Ser Glu Val Lys Val Ala 
945                 950                 955                 960 


Ser Thr Pro Val Ser Gly Ser Leu Phe Leu Ala Ser Ser Ala Pro His 
                965                 970                 975     


Arg 
    


<210>  3974
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRL6__Homo_sapiens__NP_001271146

<400>  3974

Met Leu Pro Ser Leu Gly Pro Met Leu Leu Trp Thr Ala Val Leu Leu 
1               5                   10                  15      


Phe Val Pro Cys Val Gly Lys Thr Val Trp Leu Tyr Leu Gln Ala Trp 
            20                  25                  30          


Pro Asn Pro Val Phe Glu Gly Asp Ala Leu Thr Leu Arg Cys Gln Gly 
        35                  40                  45              


Trp Lys Asn Thr Pro Leu Ser Gln Val Lys Phe Tyr Arg Asp Gly Lys 
    50                  55                  60                  


Phe Leu His Phe Ser Lys Glu Asn Gln Thr Leu Ser Met Gly Ala Ala 
65                  70                  75                  80  


Thr Val Gln Ser Arg Gly Gln Tyr Ser Cys Ser Gly Gln Val Met Tyr 
                85                  90                  95      


Ile Pro Gln Thr Phe Thr Gln Thr Ser Glu Thr Ala Met Val Gln Val 
            100                 105                 110         


Gln Glu Leu Phe Pro Pro Pro Val Leu Ser Ala Ile Pro Ser Pro Glu 
        115                 120                 125             


Pro Arg Glu Gly Ser Leu Val Thr Leu Arg Cys Gln Thr Lys Leu His 
    130                 135                 140                 


Pro Leu Arg Ser Ala Leu Arg Leu Leu Phe Ser Phe His Lys Asp Gly 
145                 150                 155                 160 


His Thr Leu Gln Asp Arg Gly Pro His Pro Glu Leu Cys Ile Pro Gly 
                165                 170                 175     


Ala Lys Glu Gly Asp Ser Gly Leu Tyr Trp Cys Glu Val Ala Pro Glu 
            180                 185                 190         


Gly Gly Gln Val Gln Lys Gln Ser Pro Gln Leu Glu Val Arg Val Gln 
        195                 200                 205             


Ala Pro Val Ser Arg Pro Val Leu Thr Leu His His Gly Pro Ala Asp 
    210                 215                 220                 


Pro Ala Val Gly Asp Met Val Gln Leu Leu Cys Glu Ala Gln Arg Gly 
225                 230                 235                 240 


Ser Pro Pro Ile Leu Tyr Ser Phe Tyr Leu Asp Glu Lys Ile Val Gly 
                245                 250                 255     


Asn His Ser Ala Pro Cys Gly Gly Thr Thr Ser Leu Leu Phe Pro Val 
            260                 265                 270         


Lys Ser Glu Gln Asp Ala Gly Asn Tyr Ser Cys Glu Ala Glu Asn Ser 
        275                 280                 285             


Val Ser Arg Glu Arg Ser Glu Pro Lys Lys Leu Ser Leu Lys Gly Ser 
    290                 295                 300                 


Gln Val Leu Phe Thr Pro Ala Ser Asn Trp Leu Val Pro Trp Leu Pro 
305                 310                 315                 320 


Ala Ser Leu Leu Gly Leu Met Val Ile Ala Ala Ala Leu Leu Val Tyr 
                325                 330                 335     


Val Arg Ser Trp Arg Lys Ala Gly Pro Leu Pro Ser Gln Ile Pro Pro 
            340                 345                 350         


Thr Ala Pro Gly Gly Glu Gln Cys Pro Leu Tyr Ala Asn Val His His 
        355                 360                 365             


Gln Lys Gly Lys Asp Glu Gly Val Val Tyr Ser Val Val His Arg Thr 
    370                 375                 380                 


Ser Lys Arg Ser Glu Ala Arg Ser Ala Glu Phe Thr Val Gly Arg Lys 
385                 390                 395                 400 


Phe Tyr His Leu Cys Gly Gly Glu Met Pro Ala Ala Gln 
                405                 410             


<210>  3975
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRLA__Homo_sapiens__NP_001171795

<400>  3975

Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val 
1               5                   10                  15      


Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser 
            20                  25                  30          


Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Gly Cys His 
        35                  40                  45              


Ala Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val Cys Thr 
    50                  55                  60                  


Glu Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu 
65                  70                  75                  80  


Ala Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe His Leu 
                85                  90                  95      


Ile Val Ser Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala Lys Pro Val 
            100                 105                 110         


Phe Glu Gly Asp Leu Leu Val Leu Arg Cys Gln Ala Trp Gln Asp Trp 
        115                 120                 125             


Pro Leu Thr Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro 
    130                 135                 140                 


Pro Gly Pro Asn Arg Glu Phe Ser Ile Thr Val Val Gln Lys Ala Asp 
145                 150                 155                 160 


Ser Gly His Tyr His Cys Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly 
                165                 170                 175     


Ile Pro Glu Thr Ala Ser Val Val Ala Ile Thr Val Gln Glu Leu Phe 
            180                 185                 190         


Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala Gly 
        195                 200                 205             


Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser 
    210                 215                 220                 


Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln 
225                 230                 235                 240 


Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp 
                245                 250                 255     


His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln Val 
            260                 265                 270         


Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser Ser 
        275                 280                 285             


Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala 
    290                 295                 300                 


Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro 
305                 310                 315                 320 


Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro 
                325                 330                 335     


Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln 
            340                 345                 350         


Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu 
        355                 360                 365             


Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
    370                 375                 380         


<210>  3976
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FCRLB__Homo_sapiens__NP_001275758

<400>  3976

Met Trp Pro Leu Thr Ala Leu Leu Leu Leu Val Pro Ser Ser Gly Gln 
1               5                   10                  15      


Ala Ala Thr Leu Glu Lys Pro Ile Leu Ser Leu His Pro Pro Trp Thr 
            20                  25                  30          


Thr Ile Phe Lys Gly Glu Arg Val Thr Leu Lys Cys Asp Gly Tyr His 
        35                  40                  45              


Pro Leu Leu Leu Glu Leu Gln Pro Ile Ser Thr Leu Trp Tyr Leu Gly 
    50                  55                  60                  


His Leu Leu Leu Pro Ser His Lys Lys Ser Ile Glu Val Gln Thr Pro 
65                  70                  75                  80  


Gly Val Tyr Arg Cys Gln Thr Arg Gly Ala Pro Val Ser Asp Pro Ile 
                85                  90                  95      


His Leu Ser Val Ser Asn Asp Trp Leu Ile Leu Gln Val Pro Tyr Ala 
            100                 105                 110         


Pro Val Phe Glu Gly Glu Pro Leu Val Leu Arg Cys Arg Gly Trp Tyr 
        115                 120                 125             


Asp Lys Val Val Tyr Lys Leu His Tyr Tyr His Asp Gly Gln Ala Val 
    130                 135                 140                 


Arg Tyr Phe His Ser Ser Ala Asn Tyr Thr Val Leu Gln Ala Arg Ala 
145                 150                 155                 160 


Ser Asp Ser Gly Arg Tyr Gln Cys Ser Gly Thr Met Arg Ile Pro Val 
                165                 170                 175     


Glu Ser Ala Pro Met Phe Ser Ala Lys Val Ala Val Thr Val Gln Ala 
            180                 185                 190         


Ala Arg Cys Ala Ala Ser Thr Gly Ala Pro Ser Thr Gln Ser Arg Ser 
        195                 200                 205             


Pro Arg Ser Arg Ser Ser Asn Arg Thr Gly Ala Arg Arg Leu Pro Pro 
    210                 215                 220                 


Pro Ala Val Ser Gly Asn Ala Val Arg Gly Cys Ser Ser Arg Gly Arg 
225                 230                 235                 240 


Val Leu Pro Trp Thr Arg Pro Pro Pro Pro Pro Gln Leu His Gly Pro 
                245                 250                 255     


Gln Pro Trp Leu Leu Val Ile Gly Arg Phe Pro Ser Glu Ser Pro Arg 
            260                 265                 270         


Cys Pro Asp Arg Ser Arg Trp Ser Pro Pro Ser Gly Thr Pro Pro Pro 
        275                 280                 285             


Pro Gly Cys Ser Ser Arg Arg Ala Ala Pro Arg Leu Arg Gly His Pro 
    290                 295                 300                 


Pro Ala Leu Arg Arg Arg Pro Trp Asn Asn Arg Leu Glu Pro 
305                 310                 315             


<210>  3977
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDFT1__Homo_sapiens__NP_001274672

<400>  3977

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
1               5                   10                  15      


Val Arg Phe Arg Ile Gly Gly Lys Arg Lys Val Met Pro Lys Met Asp 
            20                  25                  30          


Gln Asp Ser Leu Ser Ser Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asn 
        35                  40                  45              


Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Glu 
    50                  55                  60                  


Met Arg Asn Ala Val Cys Ile Phe Tyr Leu Val Leu Arg Ala Leu Asp 
65                  70                  75                  80  


Thr Leu Glu Asp Asp Met Thr Ile Ser Val Glu Lys Lys Val Pro Leu 
                85                  90                  95      


Leu His Asn Phe His Ser Phe Leu Tyr Gln Pro Asp Trp Arg Phe Met 
            100                 105                 110         


Glu Ser Lys Glu Lys Asp Arg Gln Val Leu Glu Asp Phe Pro Thr Ile 
        115                 120                 125             


Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
    130                 135                 140                 


Asp Ile Cys Arg Arg Met Gly Ile Gly Met Ala Glu Phe Leu Asp Lys 
145                 150                 155                 160 


His Val Thr Ser Glu Gln Glu Trp Asp Lys Tyr Cys His Tyr Val Ala 
                165                 170                 175     


Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
            180                 185                 190         


Glu Asp Pro Leu Val Gly Glu Asp Thr Glu Arg Ala Asn Ser Met Gly 
        195                 200                 205             


Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
    210                 215                 220                 


Gln Gly Gly Arg Glu Phe Trp Pro Gln Glu Val Trp Ser Arg Tyr Val 
225                 230                 235                 240 


Lys Lys Leu Gly Asp Phe Ala Lys Pro Glu Asn Ile Asp Leu Ala Val 
                245                 250                 255     


Gln Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu His His Ile Pro Asp 
            260                 265                 270         


Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
        275                 280                 285             


Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
    290                 295                 300                 


Asn Asn Gln Gln Val Phe Lys Gly Ala Val Lys Ile Arg Lys Gly Gln 
305                 310                 315                 320 


Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                325                 330                 335     


Ile Ile Tyr Gln Tyr Met Glu Glu Ile Tyr His Arg Ile Pro Asp Ser 
            340                 345                 350         


Asp Pro Ser Ser Ser Lys Thr Arg Gln Ile Ile Ser Thr Ile Arg Thr 
        355                 360                 365             


Gln Asn Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
    370                 375                 380                 


Ile Tyr Leu Ser Phe Val Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
385                 390                 395                 400 


Leu Thr Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Thr Gly Glu 
                405                 410                 415     


His 
    


<210>  3978
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDPS__Homo_sapiens__NP_001129293

<400>  3978

Met Pro Leu Ser Arg Trp Leu Arg Ser Val Gly Val Phe Leu Leu Pro 
1               5                   10                  15      


Ala Pro Tyr Trp Ala Pro Arg Glu Arg Trp Leu Gly Ser Leu Arg Arg 
            20                  25                  30          


Pro Ser Leu Val His Gly Tyr Pro Val Leu Ala Trp His Ser Ala Arg 
        35                  40                  45              


Cys Trp Cys Gln Ala Trp Thr Glu Glu Pro Arg Ala Leu Cys Ser Ser 
    50                  55                  60                  


Leu Arg Met Asn Gly Asp Gln Asn Ser Asp Val Tyr Ala Gln Glu Lys 
65                  70                  75                  80  


Gln Asp Phe Val Gln His Phe Ser Gln Ile Val Arg Val Leu Thr Glu 
                85                  90                  95      


Asp Glu Met Gly His Pro Glu Ile Gly Asp Ala Ile Ala Arg Leu Lys 
            100                 105                 110         


Glu Val Leu Glu Tyr Asn Ala Ile Gly Gly Lys Tyr Asn Arg Gly Leu 
        115                 120                 125             


Thr Val Val Val Ala Phe Arg Glu Leu Val Glu Pro Arg Lys Gln Asp 
    130                 135                 140                 


Ala Asp Ser Leu Gln Arg Ala Trp Thr Val Gly Trp Cys Val Glu Leu 
145                 150                 155                 160 


Leu Gln Ala Phe Phe Leu Val Ala Asp Asp Ile Met Asp Ser Ser Leu 
                165                 170                 175     


Thr Arg Arg Gly Gln Ile Cys Trp Tyr Gln Lys Pro Gly Val Gly Leu 
            180                 185                 190         


Asp Ala Ile Asn Asp Ala Asn Leu Leu Glu Ala Cys Ile Tyr Arg Leu 
        195                 200                 205             


Leu Lys Leu Tyr Cys Arg Glu Gln Pro Tyr Tyr Leu Asn Leu Ile Glu 
    210                 215                 220                 


Leu Phe Leu Gln Ser Ser Tyr Gln Thr Glu Ile Gly Gln Thr Leu Asp 
225                 230                 235                 240 


Leu Leu Thr Ala Pro Gln Gly Asn Val Asp Leu Val Arg Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Lys Ser Ile Val Lys Tyr Lys Thr Ala Phe Tyr Ser Phe 
            260                 265                 270         


Tyr Leu Pro Ile Ala Ala Ala Met Tyr Met Ala Gly Ile Asp Gly Glu 
        275                 280                 285             


Lys Glu His Ala Asn Ala Lys Lys Ile Leu Leu Glu Met Gly Glu Phe 
    290                 295                 300                 


Phe Gln Ile Gln Asp Asp Tyr Leu Asp Leu Phe Gly Asp Pro Ser Val 
305                 310                 315                 320 


Thr Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
                325                 330                 335     


Val Val Gln Cys Leu Gln Arg Ala Thr Pro Glu Gln Tyr Gln Ile Leu 
            340                 345                 350         


Lys Glu Asn Tyr Gly Gln Lys Glu Ala Glu Lys Val Ala Arg Val Lys 
        355                 360                 365             


Ala Leu Tyr Glu Glu Leu Asp Leu Pro Ala Val Phe Leu Gln Tyr Glu 
    370                 375                 380                 


Glu Asp Ser Tyr Ser His Ile Met Ala Leu Ile Glu Gln Tyr Ala Ala 
385                 390                 395                 400 


Pro Leu Pro Pro Ala Val Phe Leu Gly Leu Ala Arg Lys Ile Tyr Lys 
                405                 410                 415     


Arg Arg Lys 
            


<210>  3979
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDX1__Homo_sapiens__NP_004100

<400>  3979

Met Ala Ala Ala Gly Gly Ala Arg Leu Leu Arg Ala Ala Ser Ala Val 
1               5                   10                  15      


Leu Gly Gly Pro Ala Gly Arg Trp Leu His His Ala Gly Ser Arg Ala 
            20                  25                  30          


Gly Ser Ser Gly Leu Leu Arg Asn Arg Gly Pro Gly Gly Ser Ala Glu 
        35                  40                  45              


Ala Ser Arg Ser Leu Ser Val Ser Ala Arg Ala Arg Ser Ser Ser Glu 
    50                  55                  60                  


Asp Lys Ile Thr Val His Phe Ile Asn Arg Asp Gly Glu Thr Leu Thr 
65                  70                  75                  80  


Thr Lys Gly Lys Val Gly Asp Ser Leu Leu Asp Val Val Val Glu Asn 
                85                  90                  95      


Asn Leu Asp Ile Asp Gly Phe Gly Ala Cys Glu Gly Thr Leu Ala Cys 
            100                 105                 110         


Ser Thr Cys His Leu Ile Phe Glu Asp His Ile Tyr Glu Lys Leu Asp 
        115                 120                 125             


Ala Ile Thr Asp Glu Glu Asn Asp Met Leu Asp Leu Ala Tyr Gly Leu 
    130                 135                 140                 


Thr Asp Arg Ser Arg Leu Gly Cys Gln Ile Cys Leu Thr Lys Ser Met 
145                 150                 155                 160 


Asp Asn Met Thr Val Arg Val Pro Glu Thr Val Ala Asp Ala Arg Gln 
                165                 170                 175     


Ser Ile Asp Val Gly Lys Thr Ser 
            180                 


<210>  3980
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDX1L__Homo_sapiens__NP_001026904

<400>  3980

Met His Val Met Ala Ala Ser Met Ala Arg Gly Gly Val Ser Ala Arg 
1               5                   10                  15      


Val Leu Leu Gln Ala Ala Arg Gly Thr Trp Trp Asn Arg Pro Gly Gly 
            20                  25                  30          


Thr Ser Gly Ser Gly Glu Gly Val Ala Leu Gly Thr Thr Arg Lys Phe 
        35                  40                  45              


Gln Ala Thr Gly Ser Arg Pro Ala Gly Glu Glu Asp Ala Gly Gly Pro 
    50                  55                  60                  


Glu Arg Pro Gly Asp Val Val Asn Val Val Phe Val Asp Arg Ser Gly 
65                  70                  75                  80  


Gln Arg Ile Pro Val Ser Gly Arg Val Gly Asp Asn Val Leu His Leu 
                85                  90                  95      


Ala Gln Arg His Gly Val Asp Leu Glu Gly Ala Cys Glu Ala Ser Leu 
            100                 105                 110         


Ala Cys Ser Thr Cys His Val Tyr Val Ser Glu Asp His Leu Asp Leu 
        115                 120                 125             


Leu Pro Pro Pro Glu Glu Arg Glu Asp Asp Met Leu Asp Met Ala Pro 
    130                 135                 140                 


Leu Leu Gln Glu Asn Ser Arg Leu Gly Cys Gln Ile Val Leu Thr Pro 
145                 150                 155                 160 


Glu Leu Glu Gly Ala Glu Phe Thr Leu Pro Lys Ile Thr Arg Asn Phe 
                165                 170                 175     


Tyr Val Asp Gly His Val Pro Lys Pro His 
            180                 185     


<210>  3981
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDXR__Homo_sapiens__NP_001244941

<400>  3981

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys Arg Val Glu Ala Leu 
    50                  55                  60                  


Cys Ser Gln Pro Arg Val Leu Asn Ser Pro Ala Leu Ser Gly Glu Gly 
65                  70                  75                  80  


Glu Asp Leu Gly Ala Ser Gln Pro Leu Ser Leu Gly Pro Thr Ser Cys 
                85                  90                  95      


His Pro Val Pro Gln Gln His Pro Gln Ala His Val Asp Ile Tyr Glu 
            100                 105                 110         


Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe Gly Val Ala Pro Asp 
        115                 120                 125             


His Pro Glu Val Lys Asn Val Ile Asn Thr Phe Thr Gln Thr Ala His 
    130                 135                 140                 


Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu Val Gly Arg Asp Val 
145                 150                 155                 160 


Thr Val Pro Glu Leu Gln Glu Ala Tyr His Ala Val Val Leu Ser Tyr 
                165                 170                 175     


Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro Gly Glu Glu Leu Pro 
            180                 185                 190         


Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp Tyr Asn Gly Leu Pro 
        195                 200                 205             


Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys Asp Thr Ala Val Ile 
    210                 215                 220                 


Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala Arg Ile Leu Leu Thr 
225                 230                 235                 240 


Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr Lys Ala Ala Leu Gly 
                245                 250                 255     


Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp Leu Val Gly Arg Arg 
            260                 265                 270         


Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu Leu Arg Glu Met Ile 
        275                 280                 285             


Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro Val Asp Phe Leu Gly 
    290                 295                 300                 


Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro Arg Lys Arg Leu Thr 
305                 310                 315                 320 


Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro Gly Pro Ala Glu Ala 
                325                 330                 335     


Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly Leu Arg Phe Phe Arg 
            340                 345                 350         


Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly Arg Arg Ala Ala Gly 
        355                 360                 365             


Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val Asp Glu Ala Thr Arg 
    370                 375                 380                 


Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro Cys Gly Leu Val Leu 
385                 390                 395                 400 


Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp Pro Ser Val Pro Phe 
                405                 410                 415     


Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu Gly Arg Val Met Asp 
            420                 425                 430         


Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys Arg Gly Pro Thr Gly 
        435                 440                 445             


Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu Thr Gly Gln Met Leu 
    450                 455                 460                 


Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser Gly Pro Arg Pro Gly 
465                 470                 475                 480 


Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg Gly Val Arg Pro Val 
                485                 490                 495     


Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu Glu Val Ala Arg Gly 
            500                 505                 510         


Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val Asp Pro Gln Glu Met 
        515                 520                 525             


Leu Arg Leu Leu Gly His 
    530                 


<210>  3982
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FECH__Homo_sapiens__NP_000131

<400>  3982

Met Arg Ser Leu Gly Ala Asn Met Ala Ala Ala Leu Arg Ala Ala Gly 
1               5                   10                  15      


Val Leu Leu Arg Asp Pro Leu Ala Ser Ser Ser Trp Arg Val Cys Gln 
            20                  25                  30          


Pro Trp Arg Trp Lys Ser Gly Ala Ala Ala Ala Ala Val Thr Thr Glu 
        35                  40                  45              


Thr Ala Gln His Ala Gln Gly Ala Lys Pro Gln Val Gln Pro Gln Lys 
    50                  55                  60                  


Arg Lys Pro Lys Thr Gly Ile Leu Met Leu Asn Met Gly Gly Pro Glu 
65                  70                  75                  80  


Thr Leu Gly Asp Val His Asp Phe Leu Leu Arg Leu Phe Leu Asp Arg 
                85                  90                  95      


Asp Leu Met Thr Leu Pro Ile Gln Asn Lys Leu Ala Pro Phe Ile Ala 
            100                 105                 110         


Lys Arg Arg Thr Pro Lys Ile Gln Glu Gln Tyr Arg Arg Ile Gly Gly 
        115                 120                 125             


Gly Ser Pro Ile Lys Ile Trp Thr Ser Lys Gln Gly Glu Gly Met Val 
    130                 135                 140                 


Lys Leu Leu Asp Glu Leu Ser Pro Asn Thr Ala Pro His Lys Tyr Tyr 
145                 150                 155                 160 


Ile Gly Phe Arg Tyr Val His Pro Leu Thr Glu Glu Ala Ile Glu Glu 
                165                 170                 175     


Met Glu Arg Asp Gly Leu Glu Arg Ala Ile Ala Phe Thr Gln Tyr Pro 
            180                 185                 190         


Gln Tyr Ser Cys Ser Thr Thr Gly Ser Ser Leu Asn Ala Ile Tyr Arg 
        195                 200                 205             


Tyr Tyr Asn Gln Val Gly Arg Lys Pro Thr Met Lys Trp Ser Thr Ile 
    210                 215                 220                 


Asp Arg Trp Pro Thr His His Leu Leu Ile Gln Cys Phe Ala Asp His 
225                 230                 235                 240 


Ile Leu Lys Glu Leu Asp His Phe Pro Leu Glu Lys Arg Ser Glu Val 
                245                 250                 255     


Val Ile Leu Phe Ser Ala His Ser Leu Pro Met Ser Val Val Asn Arg 
            260                 265                 270         


Gly Asp Pro Tyr Pro Gln Glu Val Ser Ala Thr Val Gln Lys Val Met 
        275                 280                 285             


Glu Arg Leu Glu Tyr Cys Asn Pro Tyr Arg Leu Val Trp Gln Ser Lys 
    290                 295                 300                 


Val Gly Pro Met Pro Trp Leu Gly Pro Gln Thr Asp Glu Ser Ile Lys 
305                 310                 315                 320 


Gly Leu Cys Glu Arg Gly Arg Lys Asn Ile Leu Leu Val Pro Ile Ala 
                325                 330                 335     


Phe Thr Ser Asp His Ile Glu Thr Leu Tyr Glu Leu Asp Ile Glu Tyr 
            340                 345                 350         


Ser Gln Val Leu Ala Lys Glu Cys Gly Val Glu Asn Ile Arg Arg Ala 
        355                 360                 365             


Glu Ser Leu Asn Gly Asn Pro Leu Phe Ser Lys Ala Leu Ala Asp Leu 
    370                 375                 380                 


Val His Ser His Ile Gln Ser Asn Glu Leu Cys Ser Lys Gln Leu Thr 
385                 390                 395                 400 


Leu Ser Cys Pro Leu Cys Val Asn Pro Val Cys Arg Glu Thr Lys Ser 
                405                 410                 415     


Phe Phe Thr Ser Gln Gln Leu 
            420             


<210>  3983
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEM1A__Homo_sapiens__NP_061178

<400>  3983

Met Asp Leu Arg Thr Ala Val Tyr Asn Ala Ala Arg Asp Gly Lys Leu 
1               5                   10                  15      


Gln Leu Leu Gln Lys Leu Leu Ser Gly Arg Ser Arg Glu Glu Leu Asp 
            20                  25                  30          


Glu Leu Thr Gly Glu Val Ala Gly Gly Gly Thr Pro Leu Leu Ile Ala 
        35                  40                  45              


Ala Arg Tyr Gly His Leu Asp Val Val Glu Tyr Leu Val Asp Arg Cys 
    50                  55                  60                  


Gly Ala Ser Val Glu Ala Gly Gly Ser Val His Phe Asp Gly Glu Thr 
65                  70                  75                  80  


Ile Glu Gly Ala Pro Pro Leu Trp Ala Ala Ser Ala Ala Gly His Leu 
                85                  90                  95      


Asp Val Val Arg Ser Leu Leu Arg Arg Gly Ala Ser Val Asn Arg Thr 
            100                 105                 110         


Thr Arg Thr Asn Ser Thr Pro Leu Arg Ala Ala Cys Phe Asp Gly His 
        115                 120                 125             


Leu Glu Val Val Arg Tyr Leu Val Gly Glu His Gln Ala Asp Leu Glu 
    130                 135                 140                 


Val Ala Asn Arg His Gly His Thr Cys Leu Met Ile Ser Cys Tyr Lys 
145                 150                 155                 160 


Gly His Arg Glu Ile Ala Arg Tyr Leu Leu Glu Gln Gly Ala Gln Val 
                165                 170                 175     


Asn Arg Arg Ser Ala Lys Gly Asn Thr Ala Leu His Asp Cys Ala Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Ile Leu Gln Leu Leu Leu Gly Cys Lys Ala Arg 
        195                 200                 205             


Met Glu Arg Asp Gly Tyr Gly Met Thr Pro Leu Leu Ala Ala Ser Val 
    210                 215                 220                 


Thr Gly His Thr Asn Ile Val Glu Tyr Leu Ile Gln Glu Gln Pro Gly 
225                 230                 235                 240 


Gln Glu Gln Val Ala Gly Gly Glu Ala Gln Pro Gly Leu Pro Gln Glu 
                245                 250                 255     


Asp Pro Ser Thr Ser Gln Gly Cys Ala Gln Pro Gln Gly Ala Pro Cys 
            260                 265                 270         


Cys Ser Ser Ser Pro Glu Glu Pro Leu Asn Gly Glu Ser Tyr Glu Ser 
        275                 280                 285             


Cys Cys Pro Thr Ser Arg Glu Ala Ala Val Glu Ala Leu Glu Leu Leu 
    290                 295                 300                 


Gly Ala Thr Tyr Val Asp Lys Lys Arg Asp Leu Leu Gly Ala Leu Lys 
305                 310                 315                 320 


His Trp Arg Arg Ala Met Glu Leu Arg His Gln Gly Gly Glu Tyr Leu 
                325                 330                 335     


Pro Lys Pro Glu Pro Pro Gln Leu Val Leu Ala Tyr Asp Tyr Ser Arg 
            340                 345                 350         


Glu Val Asn Thr Thr Glu Glu Leu Glu Ala Leu Ile Thr Asp Pro Asp 
        355                 360                 365             


Glu Met Arg Met Gln Ala Leu Leu Ile Arg Glu Arg Ile Leu Gly Pro 
    370                 375                 380                 


Ser His Pro Asp Thr Ser Tyr Tyr Ile Arg Tyr Arg Gly Ala Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Gly Asn Phe Glu Arg Cys Ile Arg Leu Trp Lys Tyr Ala 
                405                 410                 415     


Leu Asp Met Gln Gln Ser Asn Leu Glu Pro Leu Ser Pro Met Thr Ala 
            420                 425                 430         


Ser Ser Phe Leu Ser Phe Ala Glu Leu Phe Ser Tyr Val Leu Gln Asp 
        435                 440                 445             


Arg Ala Ala Lys Gly Ser Leu Gly Thr Gln Ile Gly Phe Ala Asp Leu 
    450                 455                 460                 


Met Gly Val Leu Thr Lys Gly Val Arg Glu Val Glu Arg Ala Leu Gln 
465                 470                 475                 480 


Leu Pro Arg Glu Pro Gly Asp Ser Ala Gln Phe Thr Lys Ala Leu Ala 
                485                 490                 495     


Ile Ile Leu His Leu Leu Tyr Leu Leu Glu Lys Val Glu Cys Thr Pro 
            500                 505                 510         


Ser Gln Glu His Leu Lys His Gln Thr Val Tyr Arg Leu Leu Lys Cys 
        515                 520                 525             


Ala Pro Arg Gly Lys Asn Gly Phe Thr Pro Leu His Met Ala Val Asp 
    530                 535                 540                 


Lys Asp Thr Thr Asn Val Gly Arg Tyr Pro Val Gly Arg Phe Pro Ser 
545                 550                 555                 560 


Leu His Val Val Lys Val Leu Leu Asp Cys Gly Ala Asp Pro Asp Ser 
                565                 570                 575     


Arg Asp Phe Asp Asn Asn Thr Pro Leu His Ile Ala Ala Gln Asn Asn 
            580                 585                 590         


Cys Pro Ala Ile Met Asn Ala Leu Ile Glu Ala Gly Ala His Met Asp 
        595                 600                 605             


Ala Thr Asn Ala Phe Lys Lys Thr Ala Tyr Glu Leu Leu Asp Glu Lys 
    610                 615                 620                 


Leu Leu Ala Arg Gly Thr Met Gln Pro Phe Asn Tyr Val Thr Leu Gln 
625                 630                 635                 640 


Cys Leu Ala Ala Arg Ala Leu Asp Lys Asn Lys Ile Pro Tyr Lys Gly 
                645                 650                 655     


Phe Ile Pro Glu Asp Leu Glu Ala Phe Ile Glu Leu His 
            660                 665                 


<210>  3984
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEM1B__Homo_sapiens__NP_056137

<400>  3984

Met Glu Gly Leu Ala Gly Tyr Val Tyr Lys Ala Ala Ser Glu Gly Lys 
1               5                   10                  15      


Val Leu Thr Leu Ala Ala Leu Leu Leu Asn Arg Ser Glu Ser Asp Ile 
            20                  25                  30          


Arg Tyr Leu Leu Gly Tyr Val Ser Gln Gln Gly Gly Gln Arg Ser Thr 
        35                  40                  45              


Pro Leu Ile Ile Ala Ala Arg Asn Gly His Ala Lys Val Val Arg Leu 
    50                  55                  60                  


Leu Leu Glu His Tyr Arg Val Gln Thr Gln Gln Thr Gly Thr Val Arg 
65                  70                  75                  80  


Phe Asp Gly Tyr Val Ile Asp Gly Ala Thr Ala Leu Trp Cys Ala Ala 
                85                  90                  95      


Gly Ala Gly His Phe Glu Val Val Lys Leu Leu Val Ser His Gly Ala 
            100                 105                 110         


Asn Val Asn His Thr Thr Val Thr Asn Ser Thr Pro Leu Arg Ala Ala 
        115                 120                 125             


Cys Phe Asp Gly Arg Leu Asp Ile Val Lys Tyr Leu Val Glu Asn Asn 
    130                 135                 140                 


Ala Asn Ile Ser Ile Ala Asn Lys Tyr Asp Asn Thr Cys Leu Met Ile 
145                 150                 155                 160 


Ala Ala Tyr Lys Gly His Thr Asp Val Val Arg Tyr Leu Leu Glu Gln 
                165                 170                 175     


Arg Ala Asp Pro Asn Ala Lys Ala His Cys Gly Ala Thr Ala Leu His 
            180                 185                 190         


Phe Ala Ala Glu Ala Gly His Ile Asp Ile Val Lys Glu Leu Ile Lys 
        195                 200                 205             


Trp Arg Ala Ala Ile Val Val Asn Gly His Gly Met Thr Pro Leu Lys 
    210                 215                 220                 


Val Ala Ala Glu Ser Cys Lys Ala Asp Val Val Glu Leu Leu Leu Ser 
225                 230                 235                 240 


His Ala Asp Cys Asp Arg Arg Ser Arg Ile Glu Ala Leu Glu Leu Leu 
                245                 250                 255     


Gly Ala Ser Phe Ala Asn Asp Arg Glu Asn Tyr Asp Ile Ile Lys Thr 
            260                 265                 270         


Tyr His Tyr Leu Tyr Leu Ala Met Leu Glu Arg Phe Gln Asp Gly Asp 
        275                 280                 285             


Asn Ile Leu Glu Lys Glu Val Leu Pro Pro Ile His Ala Tyr Gly Asn 
    290                 295                 300                 


Arg Thr Glu Cys Arg Asn Pro Gln Glu Leu Glu Ser Ile Arg Gln Asp 
305                 310                 315                 320 


Arg Asp Ala Leu His Met Glu Gly Leu Ile Val Arg Glu Arg Ile Leu 
                325                 330                 335     


Gly Ala Asp Asn Ile Asp Val Ser His Pro Ile Ile Tyr Arg Gly Ala 
            340                 345                 350         


Val Tyr Ala Asp Asn Met Glu Phe Glu Gln Cys Ile Lys Leu Trp Leu 
        355                 360                 365             


His Ala Leu His Leu Arg Gln Lys Gly Asn Arg Asn Thr His Lys Asp 
    370                 375                 380                 


Leu Leu Arg Phe Ala Gln Val Phe Ser Gln Met Ile His Leu Asn Glu 
385                 390                 395                 400 


Thr Val Lys Ala Pro Asp Ile Glu Cys Val Leu Arg Cys Ser Val Leu 
                405                 410                 415     


Glu Ile Glu Gln Ser Met Asn Arg Val Lys Asn Ile Ser Asp Ala Asp 
            420                 425                 430         


Val His Asn Ala Met Asp Asn Tyr Glu Cys Asn Leu Tyr Thr Phe Leu 
        435                 440                 445             


Tyr Leu Val Cys Ile Ser Thr Lys Thr Gln Cys Ser Glu Glu Asp Gln 
    450                 455                 460                 


Cys Lys Ile Asn Lys Gln Ile Tyr Asn Leu Ile His Leu Asp Pro Arg 
465                 470                 475                 480 


Thr Arg Glu Gly Phe Thr Leu Leu His Leu Ala Val Asn Ser Asn Thr 
                485                 490                 495     


Pro Val Asp Asp Phe His Thr Asn Asp Val Cys Ser Phe Pro Asn Ala 
            500                 505                 510         


Leu Val Thr Lys Leu Leu Leu Asp Cys Gly Ala Glu Val Asn Ala Val 
        515                 520                 525             


Asp Asn Glu Gly Asn Ser Ala Leu His Ile Ile Val Gln Tyr Asn Arg 
    530                 535                 540                 


Pro Ile Ser Asp Phe Leu Thr Leu His Ser Ile Ile Ile Ser Leu Val 
545                 550                 555                 560 


Glu Ala Gly Ala His Thr Asp Met Thr Asn Lys Gln Asn Lys Thr Pro 
                565                 570                 575     


Leu Asp Lys Ser Thr Thr Gly Val Ser Glu Ile Leu Leu Lys Thr Gln 
            580                 585                 590         


Met Lys Met Ser Leu Lys Cys Leu Ala Ala Arg Ala Val Arg Ala Asn 
        595                 600                 605             


Asp Ile Asn Tyr Gln Asp Gln Ile Pro Arg Thr Leu Glu Glu Phe Val 
    610                 615                 620                 


Gly Phe His 
625         


<210>  3985
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEM1C__Homo_sapiens__NP_064562

<400>  3985

Met Asp Leu Lys Thr Ala Val Phe Asn Ala Ala Arg Asp Gly Lys Leu 
1               5                   10                  15      


Arg Leu Leu Thr Lys Leu Leu Ala Ser Lys Ser Lys Glu Glu Val Ser 
            20                  25                  30          


Ser Leu Ile Ser Glu Lys Thr Asn Gly Ala Thr Pro Leu Leu Met Ala 
        35                  40                  45              


Ala Arg Tyr Gly His Leu Asp Met Val Glu Phe Leu Leu Glu Gln Cys 
    50                  55                  60                  


Ser Ala Ser Ile Glu Val Gly Gly Ser Val Asn Phe Asp Gly Glu Thr 
65                  70                  75                  80  


Ile Glu Gly Ala Pro Pro Leu Trp Ala Ala Ser Ala Ala Gly His Leu 
                85                  90                  95      


Lys Val Val Gln Ser Leu Leu Asn His Gly Ala Ser Val Asn Asn Thr 
            100                 105                 110         


Thr Leu Thr Asn Ser Thr Pro Leu Arg Ala Ala Cys Phe Asp Gly His 
        115                 120                 125             


Leu Glu Ile Val Lys Tyr Leu Val Glu His Lys Ala Asp Leu Glu Val 
    130                 135                 140                 


Ser Asn Arg His Gly His Thr Cys Leu Met Ile Ser Cys Tyr Lys Gly 
145                 150                 155                 160 


His Lys Glu Ile Ala Gln Tyr Leu Leu Glu Lys Gly Ala Asp Val Asn 
                165                 170                 175     


Arg Lys Ser Val Lys Gly Asn Thr Ala Leu His Asp Cys Ala Glu Ser 
            180                 185                 190         


Gly Ser Leu Asp Ile Met Lys Met Leu Leu Met Tyr Cys Ala Lys Met 
        195                 200                 205             


Glu Lys Asp Gly Tyr Gly Met Thr Pro Leu Leu Ser Ala Ser Val Thr 
    210                 215                 220                 


Gly His Thr Asn Ile Val Asp Phe Leu Thr His His Ala Gln Thr Ser 
225                 230                 235                 240 


Lys Thr Glu Arg Ile Asn Ala Leu Glu Leu Leu Gly Ala Thr Phe Val 
                245                 250                 255     


Asp Lys Lys Arg Asp Leu Leu Gly Ala Leu Lys Tyr Trp Lys Lys Ala 
            260                 265                 270         


Met Asn Met Arg Tyr Ser Asp Arg Thr Asn Ile Ile Ser Lys Pro Val 
        275                 280                 285             


Pro Gln Thr Leu Ile Met Ala Tyr Asp Tyr Ala Lys Glu Val Asn Ser 
    290                 295                 300                 


Ala Glu Glu Leu Glu Gly Leu Ile Ala Asp Pro Asp Glu Met Arg Met 
305                 310                 315                 320 


Gln Ala Leu Leu Ile Arg Glu Arg Ile Leu Gly Pro Ser His Pro Asp 
                325                 330                 335     


Thr Ser Tyr Tyr Ile Arg Tyr Arg Gly Ala Val Tyr Ala Asp Ser Gly 
            340                 345                 350         


Asn Phe Lys Arg Cys Ile Asn Leu Trp Lys Tyr Ala Leu Asp Met Gln 
        355                 360                 365             


Gln Ser Asn Leu Asp Pro Leu Ser Pro Met Thr Ala Ser Ser Leu Leu 
    370                 375                 380                 


Ser Phe Ala Glu Leu Phe Ser Phe Met Leu Gln Asp Arg Ala Lys Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Thr Val Thr Phe Asp Asp Leu Met Gly Ile Leu Cys 
                405                 410                 415     


Lys Ser Val Leu Glu Ile Glu Arg Ala Ile Lys Gln Thr Gln Cys Pro 
            420                 425                 430         


Ala Asp Pro Leu Gln Leu Asn Lys Ala Leu Ser Ile Ile Leu His Leu 
        435                 440                 445             


Ile Cys Leu Leu Glu Lys Val Pro Cys Thr Leu Glu Gln Asp His Phe 
    450                 455                 460                 


Lys Lys Gln Thr Ile Tyr Arg Phe Leu Lys Leu His Pro Arg Gly Lys 
465                 470                 475                 480 


Asn Asn Phe Ser Pro Leu His Leu Ala Val Asp Lys Asn Thr Thr Cys 
                485                 490                 495     


Val Gly Arg Tyr Pro Val Cys Lys Phe Pro Ser Leu Gln Val Thr Ala 
            500                 505                 510         


Ile Leu Ile Glu Cys Gly Ala Asp Val Asn Val Arg Asp Ser Asp Asp 
        515                 520                 525             


Asn Ser Pro Leu His Ile Ala Ala Leu Asn Asn His Pro Asp Ile Met 
    530                 535                 540                 


Asn Leu Leu Ile Lys Ser Gly Ala His Phe Asp Ala Thr Asn Leu His 
545                 550                 555                 560 


Lys Gln Thr Ala Ser Asp Leu Leu Asp Glu Lys Glu Ile Ala Lys Asn 
                565                 570                 575     


Leu Ile Gln Pro Ile Asn His Thr Thr Leu Gln Cys Leu Ala Ala Arg 
            580                 585                 590         


Val Ile Val Asn His Arg Ile Tyr Tyr Lys Gly His Ile Pro Glu Lys 
        595                 600                 605             


Leu Glu Thr Phe Val Ser Leu His Arg 
    610                 615         


<210>  3986
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEN1__Homo_sapiens__NP_004102

<400>  3986

Met Gly Ile Gln Gly Leu Ala Lys Leu Ile Ala Asp Val Ala Pro Ser 
1               5                   10                  15      


Ala Ile Arg Glu Asn Asp Ile Lys Ser Tyr Phe Gly Arg Lys Val Ala 
            20                  25                  30          


Ile Asp Ala Ser Met Ser Ile Tyr Gln Phe Leu Ile Ala Val Arg Gln 
        35                  40                  45              


Gly Gly Asp Val Leu Gln Asn Glu Glu Gly Glu Thr Thr Ser His Leu 
    50                  55                  60                  


Met Gly Met Phe Tyr Arg Thr Ile Arg Met Met Glu Asn Gly Ile Lys 
65                  70                  75                  80  


Pro Val Tyr Val Phe Asp Gly Lys Pro Pro Gln Leu Lys Ser Gly Glu 
                85                  90                  95      


Leu Ala Lys Arg Ser Glu Arg Arg Ala Glu Ala Glu Lys Gln Leu Gln 
            100                 105                 110         


Gln Ala Gln Ala Ala Gly Ala Glu Gln Glu Val Glu Lys Phe Thr Lys 
        115                 120                 125             


Arg Leu Val Lys Val Thr Lys Gln His Asn Asp Glu Cys Lys His Leu 
    130                 135                 140                 


Leu Ser Leu Met Gly Ile Pro Tyr Leu Asp Ala Pro Ser Glu Ala Glu 
145                 150                 155                 160 


Ala Ser Cys Ala Ala Leu Val Lys Ala Gly Lys Val Tyr Ala Ala Ala 
                165                 170                 175     


Thr Glu Asp Met Asp Cys Leu Thr Phe Gly Ser Pro Val Leu Met Arg 
            180                 185                 190         


His Leu Thr Ala Ser Glu Ala Lys Lys Leu Pro Ile Gln Glu Phe His 
        195                 200                 205             


Leu Ser Arg Ile Leu Gln Glu Leu Gly Leu Asn Gln Glu Gln Phe Val 
    210                 215                 220                 


Asp Leu Cys Ile Leu Leu Gly Ser Asp Tyr Cys Glu Ser Ile Arg Gly 
225                 230                 235                 240 


Ile Gly Pro Lys Arg Ala Val Asp Leu Ile Gln Lys His Lys Ser Ile 
                245                 250                 255     


Glu Glu Ile Val Arg Arg Leu Asp Pro Asn Lys Tyr Pro Val Pro Glu 
            260                 265                 270         


Asn Trp Leu His Lys Glu Ala His Gln Leu Phe Leu Glu Pro Glu Val 
        275                 280                 285             


Leu Asp Pro Glu Ser Val Glu Leu Lys Trp Ser Glu Pro Asn Glu Glu 
    290                 295                 300                 


Glu Leu Ile Lys Phe Met Cys Gly Glu Lys Gln Phe Ser Glu Glu Arg 
305                 310                 315                 320 


Ile Arg Ser Gly Val Lys Arg Leu Ser Lys Ser Arg Gln Gly Ser Thr 
                325                 330                 335     


Gln Gly Arg Leu Asp Asp Phe Phe Lys Val Thr Gly Ser Leu Ser Ser 
            340                 345                 350         


Ala Lys Arg Lys Glu Pro Glu Pro Lys Gly Ser Thr Lys Lys Lys Ala 
        355                 360                 365             


Lys Thr Gly Ala Ala Gly Lys Phe Lys Arg Gly Lys 
    370                 375                 380 


<210>  3987
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FERD3L__Homo_sapiens__NP_690862

<400>  3987

Met Ala Ala Tyr Pro Glu Ser Cys Val Asp Thr Thr Val Leu Asp Phe 
1               5                   10                  15      


Val Ala Asp Leu Ser Leu Ala Ser Pro Arg Arg Pro Leu Leu Cys Asp 
            20                  25                  30          


Phe Ala Pro Gly Val Ser Leu Gly Asp Pro Ala Leu Ala Leu Arg Glu 
        35                  40                  45              


Gly Arg Pro Arg Arg Met Ala Arg Phe Glu Glu Gly Asp Pro Glu Glu 
    50                  55                  60                  


Glu Glu Cys Glu Val Asp Gln Gly Asp Gly Glu Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Arg Gly Arg Gly Val Ser Leu Leu Gly Arg Pro Lys Arg Lys Arg 
                85                  90                  95      


Val Ile Thr Tyr Ala Gln Arg Gln Ala Ala Asn Ile Arg Glu Arg Lys 
            100                 105                 110         


Arg Met Phe Asn Leu Asn Glu Ala Phe Asp Gln Leu Arg Arg Lys Val 
        115                 120                 125             


Pro Thr Phe Ala Tyr Glu Lys Arg Leu Ser Arg Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Ile Val Tyr Ile Ser Phe Met Thr Glu Leu Leu Glu Ser Cys 
145                 150                 155                 160 


Glu Lys Lys Glu Ser Gly 
                165     


<210>  3988
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FER__Homo_sapiens__NP_005237

<400>  3988

Met Gly Phe Gly Ser Asp Leu Lys Asn Ser His Glu Ala Val Leu Lys 
1               5                   10                  15      


Leu Gln Asp Trp Glu Leu Arg Leu Leu Glu Thr Val Lys Lys Phe Met 
            20                  25                  30          


Ala Leu Arg Ile Lys Ser Asp Lys Glu Tyr Ala Ser Thr Leu Gln Asn 
        35                  40                  45              


Leu Cys Asn Gln Val Asp Lys Glu Ser Thr Val Gln Met Asn Tyr Val 
    50                  55                  60                  


Ser Asn Val Ser Lys Ser Trp Leu Leu Met Ile Gln Gln Thr Glu Gln 
65                  70                  75                  80  


Leu Ser Arg Ile Met Lys Thr His Ala Glu Asp Leu Asn Ser Gly Pro 
                85                  90                  95      


Leu His Arg Leu Thr Met Met Ile Lys Asp Lys Gln Gln Val Lys Lys 
            100                 105                 110         


Ser Tyr Ile Gly Val His Gln Gln Ile Glu Ala Glu Met Ile Lys Val 
        115                 120                 125             


Thr Lys Thr Glu Leu Glu Lys Leu Lys Cys Ser Tyr Arg Gln Leu Ile 
    130                 135                 140                 


Lys Glu Met Asn Ser Ala Lys Glu Lys Tyr Lys Glu Ala Leu Ala Lys 
145                 150                 155                 160 


Gly Lys Glu Thr Glu Lys Ala Lys Glu Arg Tyr Asp Lys Ala Thr Met 
                165                 170                 175     


Lys Leu His Met Leu His Asn Gln Tyr Val Leu Ala Leu Lys Gly Ala 
            180                 185                 190         


Gln Leu His Gln Asn Gln Tyr Tyr Asp Ile Thr Leu Pro Leu Leu Leu 
        195                 200                 205             


Asp Ser Leu Gln Lys Met Gln Glu Glu Met Ile Lys Ala Leu Lys Gly 
    210                 215                 220                 


Ile Phe Asp Glu Tyr Ser Gln Ile Thr Ser Leu Val Thr Glu Glu Ile 
225                 230                 235                 240 


Val Asn Val His Lys Glu Ile Gln Met Ser Val Glu Gln Ile Asp Pro 
                245                 250                 255     


Ser Thr Glu Tyr Asn Asn Phe Ile Asp Val His Arg Thr Thr Ala Ala 
            260                 265                 270         


Lys Glu Gln Glu Ile Glu Phe Asp Thr Ser Leu Leu Glu Glu Asn Glu 
        275                 280                 285             


Asn Leu Gln Ala Asn Glu Ile Met Trp Asn Asn Leu Thr Ala Glu Ser 
    290                 295                 300                 


Leu Gln Val Met Leu Lys Thr Leu Ala Glu Glu Leu Met Gln Thr Gln 
305                 310                 315                 320 


Gln Met Leu Leu Asn Lys Glu Glu Ala Val Leu Glu Leu Glu Lys Arg 
                325                 330                 335     


Ile Glu Glu Ser Ser Glu Thr Cys Glu Lys Lys Ser Asp Ile Val Leu 
            340                 345                 350         


Leu Leu Ser Gln Lys Gln Ala Leu Glu Glu Leu Lys Gln Ser Val Gln 
        355                 360                 365             


Gln Leu Arg Cys Thr Glu Ala Lys Phe Ser Ala Gln Lys Glu Leu Leu 
    370                 375                 380                 


Glu Gln Lys Val Gln Glu Asn Asp Gly Lys Glu Pro Pro Pro Val Val 
385                 390                 395                 400 


Asn Tyr Glu Glu Asp Ala Arg Ser Val Thr Ser Met Glu Arg Lys Glu 
                405                 410                 415     


Arg Leu Ser Lys Phe Glu Ser Ile Arg His Ser Ile Ala Gly Ile Ile 
            420                 425                 430         


Arg Ser Pro Lys Ser Ala Leu Gly Ser Ser Ala Leu Ser Asp Met Ile 
        435                 440                 445             


Ser Ile Ser Glu Lys Pro Leu Ala Glu Gln Asp Trp Tyr His Gly Ala 
    450                 455                 460                 


Ile Pro Arg Ile Glu Ala Gln Glu Leu Leu Lys Lys Gln Gly Asp Phe 
465                 470                 475                 480 


Leu Val Arg Glu Ser His Gly Lys Pro Gly Glu Tyr Val Leu Ser Val 
                485                 490                 495     


Tyr Ser Asp Gly Gln Arg Arg His Phe Ile Ile Gln Tyr Val Asp Asn 
            500                 505                 510         


Met Tyr Arg Phe Glu Gly Thr Gly Phe Ser Asn Ile Pro Gln Leu Ile 
        515                 520                 525             


Asp His His Tyr Thr Thr Lys Gln Val Ile Thr Lys Lys Ser Gly Val 
    530                 535                 540                 


Val Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys Trp Ile Leu Ser His 
545                 550                 555                 560 


Glu Asp Val Ile Leu Gly Glu Leu Leu Gly Lys Gly Asn Phe Gly Glu 
                565                 570                 575     


Val Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser Val Ala Val Lys Thr 
            580                 585                 590         


Cys Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile Lys Phe Leu Gln Glu 
        595                 600                 605             


Ala Lys Ile Leu Lys Gln Tyr Asp His Pro Asn Ile Val Lys Leu Ile 
    610                 615                 620                 


Gly Val Cys Thr Gln Arg Gln Pro Val Tyr Ile Ile Met Glu Leu Val 
625                 630                 635                 640 


Ser Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg Lys Lys Asp Glu Leu 
                645                 650                 655     


Lys Leu Lys Gln Leu Val Lys Phe Ser Leu Asp Ala Ala Ala Gly Met 
            660                 665                 670         


Leu Tyr Leu Glu Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg 
        675                 680                 685             


Asn Cys Leu Val Gly Glu Asn Asn Val Leu Lys Ile Ser Asp Phe Gly 
    690                 695                 700                 


Met Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser Ser Ser Gly Leu Lys 
705                 710                 715                 720 


Gln Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg 
                725                 730                 735     


Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu 
            740                 745                 750         


Thr Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly Met Thr Asn Gln Gln 
        755                 760                 765             


Ala Arg Glu Gln Val Glu Arg Gly Tyr Arg Met Ser Ala Pro Gln His 
    770                 775                 780                 


Cys Pro Glu Asp Ile Ser Lys Ile Met Met Lys Cys Trp Asp Tyr Lys 
785                 790                 795                 800 


Pro Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln Lys Glu Leu Thr Ile 
                805                 810                 815     


Ile Lys Arg Lys Leu Thr 
            820         


<210>  3989
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FERMT1__Homo_sapiens__NP_060141

<400>  3989

Met Leu Ser Ser Thr Asp Phe Thr Phe Ala Ser Trp Glu Leu Val Val 
1               5                   10                  15      


Arg Val Asp His Pro Asn Glu Glu Gln Gln Lys Asp Val Thr Leu Arg 
            20                  25                  30          


Val Ser Gly Asp Leu His Val Gly Gly Val Met Leu Lys Leu Val Glu 
        35                  40                  45              


Gln Ile Asn Ile Ser Gln Asp Trp Ser Asp Phe Ala Leu Trp Trp Glu 
    50                  55                  60                  


Gln Lys His Cys Trp Leu Leu Lys Thr His Trp Thr Leu Asp Lys Tyr 
65                  70                  75                  80  


Gly Val Gln Ala Asp Ala Lys Leu Leu Phe Thr Pro Gln His Lys Met 
                85                  90                  95      


Leu Arg Leu Arg Leu Pro Asn Leu Lys Met Val Arg Leu Arg Val Ser 
            100                 105                 110         


Phe Ser Ala Val Val Phe Lys Ala Val Ser Asp Ile Cys Lys Ile Leu 
        115                 120                 125             


Asn Ile Arg Arg Ser Glu Glu Leu Ser Leu Leu Lys Pro Ser Gly Asp 
    130                 135                 140                 


Tyr Phe Lys Lys Lys Lys Lys Lys Asp Lys Asn Asn Lys Glu Pro Ile 
145                 150                 155                 160 


Ile Glu Asp Ile Leu Asn Leu Glu Ser Ser Pro Thr Ala Ser Gly Ser 
                165                 170                 175     


Ser Val Ser Pro Gly Leu Tyr Ser Lys Thr Met Thr Pro Ile Tyr Asp 
            180                 185                 190         


Pro Ile Asn Gly Thr Pro Ala Ser Ser Thr Met Thr Trp Phe Ser Asp 
        195                 200                 205             


Ser Pro Leu Thr Glu Gln Asn Cys Ser Ile Leu Ala Phe Ser Gln Pro 
    210                 215                 220                 


Pro Gln Ser Pro Glu Ala Leu Ala Asp Met Tyr Gln Pro Arg Ser Leu 
225                 230                 235                 240 


Val Asp Lys Ala Lys Leu Asn Ala Gly Trp Leu Asp Ser Ser Arg Ser 
                245                 250                 255     


Leu Met Glu Gln Gly Ile Gln Glu Asp Glu Gln Leu Leu Leu Arg Phe 
            260                 265                 270         


Lys Tyr Tyr Ser Phe Phe Asp Leu Asn Pro Lys Tyr Asp Ala Val Arg 
        275                 280                 285             


Ile Asn Gln Leu Tyr Glu Gln Ala Arg Trp Ala Ile Leu Leu Glu Glu 
    290                 295                 300                 


Ile Asp Cys Thr Glu Glu Glu Met Leu Ile Phe Ala Ala Leu Gln Tyr 
305                 310                 315                 320 


His Ile Ser Lys Leu Ser Leu Ser Ala Glu Thr Gln Asp Phe Ala Gly 
                325                 330                 335     


Glu Ser Glu Val Asp Glu Ile Glu Ala Ala Leu Ser Asn Leu Glu Val 
            340                 345                 350         


Thr Leu Glu Gly Gly Lys Ala Asp Ser Leu Leu Glu Asp Ile Thr Asp 
        355                 360                 365             


Ile Pro Lys Leu Ala Asp Asn Leu Lys Leu Phe Arg Pro Lys Lys Leu 
    370                 375                 380                 


Leu Pro Lys Ala Phe Lys Gln Tyr Trp Phe Ile Phe Lys Asp Thr Ser 
385                 390                 395                 400 


Ile Ala Tyr Phe Lys Asn Lys Glu Leu Glu Gln Gly Glu Pro Leu Glu 
                405                 410                 415     


Lys Leu Asn Leu Arg Gly Cys Glu Val Val Pro Asp Val Asn Val Ala 
            420                 425                 430         


Gly Arg Lys Phe Gly Ile Lys Leu Leu Ile Pro Val Ala Asp Gly Met 
        435                 440                 445             


Asn Glu Met Tyr Leu Arg Cys Asp His Glu Asn Gln Tyr Ala Gln Trp 
    450                 455                 460                 


Met Ala Ala Cys Met Leu Ala Ser Lys Gly Lys Thr Met Ala Asp Ser 
465                 470                 475                 480 


Ser Tyr Gln Pro Glu Val Leu Asn Ile Leu Ser Phe Leu Arg Met Lys 
                485                 490                 495     


Asn Arg Asn Ser Ala Ser Gln Val Ala Ser Ser Leu Glu Asn Met Asp 
            500                 505                 510         


Met Asn Pro Glu Cys Phe Val Ser Pro Arg Cys Ala Lys Arg His Lys 
        515                 520                 525             


Ser Lys Gln Leu Ala Ala Arg Ile Leu Glu Ala His Gln Asn Val Ala 
    530                 535                 540                 


Gln Met Pro Leu Val Glu Ala Lys Leu Arg Phe Ile Gln Ala Trp Gln 
545                 550                 555                 560 


Ser Leu Pro Glu Phe Gly Leu Thr Tyr Tyr Leu Val Arg Phe Lys Gly 
                565                 570                 575     


Ser Lys Lys Asp Asp Ile Leu Gly Val Ser Tyr Asn Arg Leu Ile Lys 
            580                 585                 590         


Ile Asp Ala Ala Thr Gly Ile Pro Val Thr Thr Trp Arg Phe Thr Asn 
        595                 600                 605             


Ile Lys Gln Trp Asn Val Asn Trp Glu Thr Arg Gln Val Val Ile Glu 
    610                 615                 620                 


Phe Asp Gln Asn Val Phe Thr Ala Phe Thr Cys Leu Ser Ala Asp Cys 
625                 630                 635                 640 


Lys Ile Val His Glu Tyr Ile Gly Gly Tyr Ile Phe Leu Ser Thr Arg 
                645                 650                 655     


Ser Lys Asp Gln Asn Glu Thr Leu Asp Glu Asp Leu Phe His Lys Leu 
            660                 665                 670         


Thr Gly Gly Gln Asp 
        675         


<210>  3990
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FERMT2__Homo_sapiens__NP_001128471

<400>  3990

Met Ala Leu Asp Gly Ile Arg Met Pro Asp Gly Cys Tyr Ala Asp Gly 
1               5                   10                  15      


Thr Trp Glu Leu Ser Val His Val Thr Asp Leu Asn Arg Asp Val Thr 
            20                  25                  30          


Leu Arg Val Thr Gly Glu Val His Ile Gly Gly Val Met Leu Lys Leu 
        35                  40                  45              


Val Glu Lys Leu Asp Val Lys Lys Asp Trp Ser Asp His Ala Leu Trp 
    50                  55                  60                  


Trp Glu Lys Lys Arg Thr Trp Leu Leu Lys Thr His Trp Thr Leu Asp 
65                  70                  75                  80  


Lys Tyr Gly Ile Gln Ala Asp Ala Lys Leu Gln Phe Thr Pro Gln His 
                85                  90                  95      


Lys Leu Leu Arg Leu Gln Leu Pro Asn Met Lys Tyr Val Lys Val Lys 
            100                 105                 110         


Val Asn Phe Ser Asp Arg Val Phe Lys Ala Val Ser Asp Ile Cys Lys 
        115                 120                 125             


Thr Phe Asn Ile Arg His Pro Glu Glu Leu Ser Leu Leu Lys Lys Pro 
    130                 135                 140                 


Arg Asp Pro Thr Lys Lys Lys Lys Lys Lys Leu Asp Asp Gln Ser Glu 
145                 150                 155                 160 


Asp Glu Ala Leu Glu Leu Glu Gly Pro Leu Ile Thr Pro Gly Ser Gly 
                165                 170                 175     


Ser Ile Tyr Ser Ser Pro Gly Leu Tyr Ser Lys Thr Met Thr Pro Thr 
            180                 185                 190         


Tyr Asp Ala His Asp Gly Ser Pro Leu Ser Pro Thr Ser Ala Trp Phe 
        195                 200                 205             


Gly Asp Ser Ala Leu Ser Glu Gly Asn Pro Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Gln Pro Ile Thr Ser Pro Glu Ile Leu Ala Lys Met Phe Lys Pro Gln 
225                 230                 235                 240 


Ala Leu Leu Asp Lys Ala Lys Ile Asn Gln Gly Trp Leu Asp Ser Ser 
                245                 250                 255     


Arg Ser Leu Met Glu Gln Asp Val Lys Glu Asn Glu Ala Leu Leu Leu 
            260                 265                 270         


Arg Phe Lys Tyr Tyr Ser Phe Phe Asp Leu Asn Pro Lys Tyr Asp Ala 
        275                 280                 285             


Ile Arg Ile Asn Gln Leu Tyr Glu Gln Ala Lys Trp Ala Ile Leu Leu 
    290                 295                 300                 


Glu Glu Ile Glu Cys Thr Glu Glu Glu Met Met Met Phe Ala Ala Leu 
305                 310                 315                 320 


Gln Tyr His Ile Asn Lys Leu Ser Ile Met Thr Ser Glu Asn His Leu 
                325                 330                 335     


Asn Asn Ser Asp Lys Glu Val Asp Glu Val Asp Ala Ala Leu Ser Asp 
            340                 345                 350         


Leu Glu Ile Thr Leu Glu Gly Gly Lys Thr Ser Thr Ile Leu Gly Asp 
        355                 360                 365             


Ile Thr Ser Ile Pro Glu Leu Ala Asp Tyr Ile Lys Val Phe Lys Pro 
    370                 375                 380                 


Lys Lys Leu Thr Leu Lys Gly Tyr Lys Gln Tyr Trp Cys Thr Phe Lys 
385                 390                 395                 400 


Asp Thr Ser Ile Ser Cys Tyr Lys Ser Lys Glu Glu Ser Ser Gly Thr 
                405                 410                 415     


Pro Ala His Gln Met Asn Leu Arg Gly Cys Glu Val Thr Pro Asp Val 
            420                 425                 430         


Asn Ile Ser Gly Gln Lys Phe Asn Ile Lys Leu Leu Ile Pro Val Ala 
        435                 440                 445             


Glu Gly Met Asn Glu Ile Trp Leu Arg Cys Asp Asn Glu Lys Gln Tyr 
    450                 455                 460                 


Ala His Trp Met Ala Ala Cys Arg Leu Ala Ser Lys Gly Lys Thr Met 
465                 470                 475                 480 


Ala Asp Ser Ser Tyr Asn Leu Glu Val Gln Asn Ile Leu Ser Phe Leu 
                485                 490                 495     


Lys Met Gln His Leu Asn Pro Asp Pro Gln Leu Ile Pro Glu Gln Ile 
            500                 505                 510         


Thr Thr Asp Ile Thr Pro Glu Cys Leu Val Ser Pro Arg Tyr Leu Lys 
        515                 520                 525             


Lys Tyr Lys Asn Lys Gln Pro Gly Tyr Ile Arg Asp Leu Ile Thr Ala 
    530                 535                 540                 


Arg Ile Leu Glu Ala His Gln Asn Val Ala Gln Met Ser Leu Ile Glu 
545                 550                 555                 560 


Ala Lys Met Arg Phe Ile Gln Ala Trp Gln Ser Leu Pro Glu Phe Gly 
                565                 570                 575     


Ile Thr His Phe Ile Ala Arg Phe Gln Gly Gly Lys Lys Glu Glu Leu 
            580                 585                 590         


Ile Gly Ile Ala Tyr Asn Arg Leu Ile Arg Met Asp Ala Ser Thr Gly 
        595                 600                 605             


Asp Ala Ile Lys Thr Trp Arg Phe Ser Asn Met Lys Gln Trp Asn Val 
    610                 615                 620                 


Asn Trp Glu Ile Lys Met Val Thr Val Glu Phe Ala Asp Glu Val Arg 
625                 630                 635                 640 


Leu Ser Phe Ile Cys Thr Glu Val Asp Cys Lys Val Val His Glu Phe 
                645                 650                 655     


Ile Gly Gly Tyr Ile Phe Leu Ser Thr Arg Ala Lys Asp Gln Asn Glu 
            660                 665                 670         


Ser Leu Asp Glu Glu Met Phe Tyr Lys Leu Thr Ser Gly Trp Val 
        675                 680                 685         


<210>  3991
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FERMT3__Homo_sapiens__NP_113659

<400>  3991

Met Ala Gly Met Lys Thr Ala Ser Gly Asp Tyr Ile Asp Ser Ser Trp 
1               5                   10                  15      


Glu Leu Arg Val Phe Val Gly Glu Glu Asp Pro Glu Ala Glu Ser Val 
            20                  25                  30          


Thr Leu Arg Val Thr Gly Glu Ser His Ile Gly Gly Val Leu Leu Lys 
        35                  40                  45              


Ile Val Glu Gln Ile Asn Arg Lys Gln Asp Trp Ser Asp His Ala Ile 
    50                  55                  60                  


Trp Trp Glu Gln Lys Arg Gln Trp Leu Leu Gln Thr His Trp Thr Leu 
65                  70                  75                  80  


Asp Lys Tyr Gly Ile Leu Ala Asp Ala Arg Leu Phe Phe Gly Pro Gln 
                85                  90                  95      


His Arg Pro Val Ile Leu Arg Leu Pro Asn Arg Arg Ala Leu Arg Leu 
            100                 105                 110         


Arg Ala Ser Phe Ser Gln Pro Leu Phe Gln Ala Val Ala Ala Ile Cys 
        115                 120                 125             


Arg Leu Leu Ser Ile Arg His Pro Glu Glu Leu Ser Leu Leu Arg Ala 
    130                 135                 140                 


Pro Glu Lys Lys Glu Lys Lys Lys Lys Glu Lys Glu Pro Glu Glu Glu 
145                 150                 155                 160 


Leu Tyr Asp Leu Ser Lys Val Val Leu Ala Gly Gly Val Ala Pro Ala 
                165                 170                 175     


Leu Phe Arg Gly Met Pro Ala His Phe Ser Asp Ser Ala Gln Thr Glu 
            180                 185                 190         


Ala Cys Tyr His Met Leu Ser Arg Pro Gln Pro Pro Pro Asp Pro Leu 
        195                 200                 205             


Leu Leu Gln Arg Leu Pro Arg Pro Ser Ser Leu Ser Asp Lys Thr Gln 
    210                 215                 220                 


Leu His Ser Arg Trp Leu Asp Ser Ser Arg Cys Leu Met Gln Gln Gly 
225                 230                 235                 240 


Ile Lys Ala Gly Asp Ala Leu Trp Leu Arg Phe Lys Tyr Tyr Ser Phe 
                245                 250                 255     


Phe Asp Leu Asp Pro Lys Thr Asp Pro Val Arg Leu Thr Gln Leu Tyr 
            260                 265                 270         


Glu Gln Ala Arg Trp Asp Leu Leu Leu Glu Glu Ile Asp Cys Thr Glu 
        275                 280                 285             


Glu Glu Met Met Val Phe Ala Ala Leu Gln Tyr His Ile Asn Lys Leu 
    290                 295                 300                 


Ser Gln Ser Gly Glu Val Gly Glu Pro Ala Gly Thr Asp Pro Gly Leu 
305                 310                 315                 320 


Asp Asp Leu Asp Val Ala Leu Ser Asn Leu Glu Val Lys Leu Glu Gly 
                325                 330                 335     


Ser Ala Pro Thr Asp Val Leu Asp Ser Leu Thr Thr Ile Pro Glu Leu 
            340                 345                 350         


Lys Asp His Leu Arg Ile Phe Arg Pro Arg Lys Leu Thr Leu Lys Gly 
        355                 360                 365             


Tyr Arg Gln His Trp Val Val Phe Lys Glu Thr Thr Leu Ser Tyr Tyr 
    370                 375                 380                 


Lys Ser Gln Asp Glu Ala Pro Gly Asp Pro Ile Gln Gln Leu Asn Leu 
385                 390                 395                 400 


Lys Gly Cys Glu Val Val Pro Asp Val Asn Val Ser Gly Gln Lys Phe 
                405                 410                 415     


Cys Ile Lys Leu Leu Val Pro Ser Pro Glu Gly Met Ser Glu Ile Tyr 
            420                 425                 430         


Leu Arg Cys Gln Asp Glu Gln Gln Tyr Ala Arg Trp Met Ala Gly Cys 
        435                 440                 445             


Arg Leu Ala Ser Lys Gly Arg Thr Met Ala Asp Ser Ser Tyr Thr Ser 
    450                 455                 460                 


Glu Val Gln Ala Ile Leu Ala Phe Leu Ser Leu Gln Arg Thr Gly Ser 
465                 470                 475                 480 


Gly Gly Pro Gly Asn His Pro His Gly Pro Asp Ala Ser Ala Glu Gly 
                485                 490                 495     


Leu Asn Pro Tyr Gly Leu Val Ala Pro Arg Phe Gln Arg Lys Phe Lys 
            500                 505                 510         


Ala Lys Gln Leu Thr Pro Arg Ile Leu Glu Ala His Gln Asn Val Ala 
        515                 520                 525             


Gln Leu Ser Leu Ala Glu Ala Gln Leu Arg Phe Ile Gln Ala Trp Gln 
    530                 535                 540                 


Ser Leu Pro Asp Phe Gly Ile Ser Tyr Val Met Val Arg Phe Lys Gly 
545                 550                 555                 560 


Ser Arg Lys Asp Glu Ile Leu Gly Ile Ala Asn Asn Arg Leu Ile Arg 
                565                 570                 575     


Ile Asp Leu Ala Val Gly Asp Val Val Lys Thr Trp Arg Phe Ser Asn 
            580                 585                 590         


Met Arg Gln Trp Asn Val Asn Trp Asp Ile Arg Gln Val Ala Ile Glu 
        595                 600                 605             


Phe Asp Glu His Ile Asn Val Ala Phe Ser Cys Val Ser Ala Ser Cys 
    610                 615                 620                 


Arg Ile Val His Glu Tyr Ile Gly Gly Tyr Ile Phe Leu Ser Thr Arg 
625                 630                 635                 640 


Glu Arg Ala Arg Gly Glu Glu Leu Asp Glu Asp Leu Phe Leu Gln Leu 
                645                 650                 655     


Thr Gly Gly His Glu Ala Phe 
            660             


<210>  3992
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FES__Homo_sapiens__NP_001137257

<400>  3992

Met Gly Phe Ser Ser Glu Leu Cys Ser Pro Gln Gly His Gly Val Leu 
1               5                   10                  15      


Gln Gln Met Gln Glu Ala Glu Leu Arg Leu Leu Glu Gly Met Arg Lys 
            20                  25                  30          


Trp Met Ala Gln Arg Val Lys Ser Asp Arg Glu Tyr Ala Gly Leu Leu 
        35                  40                  45              


His His Met Ser Leu Gln Asp Ser Gly Gly Gln Ser Arg Ala Ile Ser 
    50                  55                  60                  


Pro Asp Ser Pro Ile Ser Gln Thr His Ser Gln Asp Ile Glu Lys Leu 
65                  70                  75                  80  


Lys Ser Gln Tyr Arg Ala Leu Ala Arg Asp Ser Ala Gln Ala Lys Arg 
                85                  90                  95      


Lys Tyr Gln Glu Ala Ser Lys Asp Lys Asp Arg Asp Lys Ala Lys Asp 
            100                 105                 110         


Lys Tyr Val Arg Ser Leu Trp Lys Leu Phe Ala His His Asn Arg Tyr 
        115                 120                 125             


Val Leu Gly Val Arg Ala Ala Gln Leu His His Gln His His His Gln 
    130                 135                 140                 


Leu Leu Leu Pro Gly Leu Leu Arg Ser Leu Gln Asp Leu His Glu Glu 
145                 150                 155                 160 


Met Ala Cys Ile Leu Lys Glu Ile Leu Gln Glu Tyr Leu Glu Ile Ser 
                165                 170                 175     


Ser Leu Val Gln Asp Glu Val Val Ala Ile His Arg Glu Met Ala Ala 
            180                 185                 190         


Ala Ala Ala Arg Ile Gln Pro Glu Ala Glu Tyr Gln Gly Phe Leu Arg 
        195                 200                 205             


Gln Tyr Gly Ser Ala Pro Asp Val Pro Pro Cys Val Thr Phe Asp Glu 
    210                 215                 220                 


Ser Leu Leu Glu Glu Gly Glu Pro Leu Glu Pro Gly Glu Leu Gln Leu 
225                 230                 235                 240 


Asn Glu Leu Thr Val Glu Ser Val Gln His Thr Leu Thr Ser Val Thr 
                245                 250                 255     


Asp Glu Leu Ala Val Ala Thr Glu Met Val Phe Arg Arg Gln Glu Met 
            260                 265                 270         


Val Thr Gln Leu Gln Gln Glu Leu Arg Asn Glu Glu Glu Asn Thr His 
        275                 280                 285             


Pro Arg Glu Arg Val Gln Leu Leu Gly Lys Arg Gln Val Leu Gln Glu 
    290                 295                 300                 


Ala Leu Gln Gly Leu Gln Val Ala Leu Cys Ser Gln Ala Lys Leu Gln 
305                 310                 315                 320 


Ala Gln Gln Glu Leu Leu Gln Thr Lys Leu Glu His Leu Gly Pro Gly 
                325                 330                 335     


Glu Pro Pro Pro Val Leu Leu Leu Gln Asp Asp Arg His Ser Thr Ser 
            340                 345                 350         


Ser Ser Glu Gln Glu Arg Glu Gly Gly Arg Thr Pro Thr Leu Glu Ile 
        355                 360                 365             


Leu Lys Ser His Ile Ser Gly Ile Phe Arg Pro Lys Phe Ser Asn Leu 
    370                 375                 380                 


Tyr Arg Leu Glu Gly Glu Gly Phe Pro Ser Ile Pro Leu Leu Ile Asp 
385                 390                 395                 400 


His Leu Leu Ser Thr Gln Gln Pro Leu Thr Lys Lys Ser Gly Val Val 
                405                 410                 415     


Leu His Arg Ala Val Pro Lys Asp Lys Trp Val Leu Asn His Glu Asp 
            420                 425                 430         


Leu Val Leu Gly Glu Gln Ile Gly Arg Gly Asn Phe Gly Glu Val Phe 
        435                 440                 445             


Ser Gly Arg Leu Arg Ala Asp Asn Thr Leu Val Ala Val Lys Ser Cys 
    450                 455                 460                 


Arg Glu Thr Leu Pro Pro Asp Leu Lys Ala Lys Phe Leu Gln Glu Ala 
465                 470                 475                 480 


Arg Ile Leu Lys Gln Tyr Ser His Pro Asn Ile Val Arg Leu Ile Gly 
                485                 490                 495     


Val Cys Thr Gln Lys Gln Pro Ile Tyr Ile Val Met Glu Leu Val Gln 
            500                 505                 510         


Gly Gly Asp Phe Leu Thr Phe Leu Arg Thr Glu Gly Ala Arg Leu Arg 
        515                 520                 525             


Val Lys Thr Leu Leu Gln Met Val Gly Asp Ala Ala Ala Gly Met Glu 
    530                 535                 540                 


Tyr Leu Glu Ser Lys Cys Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
545                 550                 555                 560 


Cys Leu Val Thr Glu Lys Asn Val Leu Lys Ile Ser Asp Phe Gly Met 
                565                 570                 575     


Ser Arg Glu Glu Ala Asp Gly Val Tyr Ala Ala Ser Gly Gly Leu Arg 
            580                 585                 590         


Gln Val Pro Val Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg 
        595                 600                 605             


Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu 
    610                 615                 620                 


Thr Phe Ser Leu Gly Ala Ser Pro Tyr Pro Asn Leu Ser Asn Gln Gln 
625                 630                 635                 640 


Thr Arg Glu Phe Val Glu Lys Gly Gly Arg Leu Pro Cys Pro Glu Leu 
                645                 650                 655     


Cys Pro Asp Ala Val Phe Arg Leu Met Glu Gln Cys Trp Ala Tyr Glu 
            660                 665                 670         


Pro Gly Gln Arg Pro Ser Phe Ser Thr Ile Tyr Gln Glu Leu Gln Ser 
        675                 680                 685             


Ile Arg Lys Arg His Arg 
    690                 


<210>  3993
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEV__Homo_sapiens__NP_059991

<400>  3993

Met Arg Gln Ser Gly Ala Ser Gln Pro Leu Leu Ile Asn Met Tyr Leu 
1               5                   10                  15      


Pro Asp Pro Val Gly Asp Gly Leu Phe Lys Asp Gly Lys Asn Pro Ser 
            20                  25                  30          


Trp Gly Pro Leu Ser Pro Ala Val Gln Lys Gly Ser Gly Gln Ile Gln 
        35                  40                  45              


Leu Trp Gln Phe Leu Leu Glu Leu Leu Ala Asp Arg Ala Asn Ala Gly 
    50                  55                  60                  


Cys Ile Ala Trp Glu Gly Gly His Gly Glu Phe Lys Leu Thr Asp Pro 
65                  70                  75                  80  


Asp Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met 
                85                  90                  95      


Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn 
            100                 105                 110         


Ile Met Ser Lys Val His Gly Lys Arg Tyr Ala Tyr Arg Phe Asp Phe 
        115                 120                 125             


Gln Gly Leu Ala Gln Ala Cys Gln Pro Pro Pro Ala His Ala His Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln Asp Gly Ala Leu 
145                 150                 155                 160 


Tyr Lys Leu Pro Ala Gly Leu Ala Pro Leu Pro Phe Pro Gly Leu Ser 
                165                 170                 175     


Lys Leu Asn Leu Met Ala Ala Ser Ala Gly Val Ala Pro Ala Gly Phe 
            180                 185                 190         


Ser Tyr Trp Pro Gly Pro Gly Pro Ala Ala Thr Ala Ala Ala Ala Thr 
        195                 200                 205             


Ala Ala Leu Tyr Pro Ser Pro Ser Leu Gln Pro Pro Pro Gly Pro Phe 
    210                 215                 220                 


Gly Ala Val Ala Ala Ala Ser His Leu Gly Gly His Tyr His 
225                 230                 235             


<210>  3994
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEZ1__Homo_sapiens__NP_005094

<400>  3994

Met Glu Ala Pro Leu Val Ser Leu Asp Glu Glu Phe Glu Asp Leu Arg 
1               5                   10                  15      


Pro Ser Cys Ser Glu Asp Pro Glu Glu Lys Pro Gln Cys Phe Tyr Gly 
            20                  25                  30          


Ser Ser Pro His His Leu Glu Asp Pro Ser Leu Ser Glu Leu Glu Asn 
        35                  40                  45              


Phe Ser Ser Glu Ile Ile Ser Phe Lys Ser Met Glu Asp Leu Val Asn 
    50                  55                  60                  


Glu Phe Asp Glu Lys Leu Asn Val Cys Phe Arg Asn Tyr Asn Ala Lys 
65                  70                  75                  80  


Thr Glu Asn Leu Ala Pro Val Lys Asn Gln Leu Gln Ile Gln Glu Glu 
                85                  90                  95      


Glu Glu Thr Leu Gln Asp Glu Glu Val Trp Asp Ala Leu Thr Asp Asn 
            100                 105                 110         


Tyr Ile Pro Ser Leu Ser Glu Asp Trp Arg Asp Pro Asn Ile Glu Ala 
        115                 120                 125             


Leu Asn Gly Asn Cys Ser Asp Thr Glu Ile His Glu Lys Glu Glu Glu 
    130                 135                 140                 


Glu Phe Asn Glu Lys Ser Glu Asn Asp Ser Gly Ile Asn Glu Glu Pro 
145                 150                 155                 160 


Leu Leu Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met Gln 
                165                 170                 175     


Asn Ser Pro Asp Pro Glu Glu Glu Glu Glu Val Leu Glu Glu Glu Asp 
            180                 185                 190         


Gly Gly Glu Thr Ser Ser Gln Ala Asp Ser Val Leu Leu Gln Glu Met 
        195                 200                 205             


Gln Ala Leu Thr Gln Thr Phe Asn Asn Asn Trp Ser Tyr Glu Gly Leu 
    210                 215                 220                 


Arg His Met Ser Gly Ser Glu Leu Thr Glu Leu Leu Asp Gln Val Glu 
225                 230                 235                 240 


Gly Ala Ile Arg Asp Phe Ser Glu Glu Leu Val Gln Gln Leu Ala Arg 
                245                 250                 255     


Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys Asn Ser Phe Ile Thr 
            260                 265                 270         


Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu Gln Arg Glu Leu Met 
        275                 280                 285             


Lys Lys Arg Arg Lys Glu Lys Gly Leu Ser Leu Gln Ser Ser Arg Ile 
    290                 295                 300                 


Glu Lys Gly Asn Gln Met Pro Leu Lys Arg Phe Ser Met Glu Gly Ile 
305                 310                 315                 320 


Ser Asn Ile Leu Gln Ser Gly Ile Arg Gln Thr Phe Gly Ser Ser Gly 
                325                 330                 335     


Thr Asp Lys Gln Tyr Leu Asn Thr Val Ile Pro Tyr Glu Lys Lys Ala 
            340                 345                 350         


Ser Pro Pro Ser Val Glu Asp Leu Gln Met Leu Thr Asn Ile Leu Phe 
        355                 360                 365             


Ala Met Lys Glu Asp Asn Glu Lys Val Pro Thr Leu Leu Thr Asp Tyr 
    370                 375                 380                 


Ile Leu Lys Val Leu Cys Pro Thr 
385                 390         


<210>  3995
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEZ2__Homo_sapiens__NP_001036013

<400>  3995

Met Ala Ala Asp Gly Asp Trp Gln Asp Phe Tyr Glu Phe Gln Glu Pro 
1               5                   10                  15      


Ala Arg Ser Leu Leu Asp Gln Glu Asn Cys Asn Ala Ser Pro Glu Pro 
            20                  25                  30          


Gly Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Asp Gly Phe Pro 
        35                  40                  45              


Ala Pro Ala Cys Ser Leu Glu Glu Lys Leu Ser Leu Cys Phe Arg Pro 
    50                  55                  60                  


Ser Asp Pro Gly Ala Glu Pro Pro Arg Thr Ala Val Arg Pro Ile Thr 
65                  70                  75                  80  


Glu Arg Ser Leu Leu Gln Gly Asp Glu Ile Trp Asn Ala Leu Thr Asp 
                85                  90                  95      


Asn Tyr Gly Asn Val Met Pro Val Asp Trp Lys Ser Ser His Thr Arg 
            100                 105                 110         


Thr Leu His Leu Leu Thr Leu Asn Leu Ser Glu Lys Gly Val Ser Asp 
        115                 120                 125             


Ser Leu Leu Phe Asp Thr Ser Asp Asp Glu Glu Leu Arg Glu Gln Leu 
    130                 135                 140                 


Asp Met His Ser Ile Ile Val Ser Cys Val Asn Asp Glu Pro Leu Phe 
145                 150                 155                 160 


Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met Gln Glu Ser 
                165                 170                 175     


Pro Asp Pro Glu Asp Asp Glu Thr Pro Thr Gln Ser Asp Arg Leu Ser 
            180                 185                 190         


Met Leu Ser Gln Glu Ile Gln Thr Leu Lys Arg Ser Ser Thr Gly Ser 
        195                 200                 205             


Tyr Glu Glu Arg Val Lys Arg Leu Ser Val Ser Glu Leu Asn Glu Ile 
    210                 215                 220                 


Leu Glu Glu Ile Glu Thr Ala Ile Lys Glu Tyr Ser Glu Glu Leu Val 
225                 230                 235                 240 


Gln Gln Leu Ala Leu Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys 
                245                 250                 255     


Asn Ser Phe Ile Ser Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu 
            260                 265                 270         


His Lys Glu Thr Ala Lys Lys Lys Lys Lys Leu Lys Asn Gly Ser Ser 
        275                 280                 285             


Gln Asn Gly Lys Asn Glu Arg Ser His Met Pro Gly Thr Arg Phe Ser 
    290                 295                 300                 


Met Glu Gly Ile Ser Asn Val Ile Gln Asn Gly Leu Arg His Thr Phe 
305                 310                 315                 320 


Gly Asn Ser Gly Gly Glu Lys Gln Tyr Leu Thr Thr Val Ile Pro Tyr 
                325                 330                 335     


Glu Lys Lys Asn Gly Pro Pro Ser Val Glu Asp Leu Gln Ile Leu Thr 
            340                 345                 350         


Lys Ile Leu Arg Ala Met Lys Glu Asp Ser Glu Lys Val Pro Ser Leu 
        355                 360                 365             


Leu Thr Asp Tyr Ile Leu Lys Val Leu Cys Pro Thr 
    370                 375                 380 


<210>  3996
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEZF1__Homo_sapiens__NP_001019784

<400>  3996

Met Asp Ser Ser Cys His Asn Ala Thr Thr Lys Met Leu Ala Thr Ala 
1               5                   10                  15      


Pro Ala Arg Gly Asn Met Met Ser Thr Ser Lys Pro Leu Ala Phe Ser 
            20                  25                  30          


Ile Glu Arg Ile Met Ala Arg Thr Pro Glu Pro Lys Ala Leu Pro Val 
        35                  40                  45              


Pro His Phe Leu Gln Gly Ala Leu Pro Lys Gly Glu Pro Lys His Ser 
    50                  55                  60                  


Leu His Leu Asn Ser Ser Ile Pro Cys Met Ile Pro Phe Val Pro Val 
65                  70                  75                  80  


Ala Tyr Asp Thr Ser Pro Lys Ala Gly Val Thr Gly Ser Glu Pro Arg 
                85                  90                  95      


Lys Ala Ser Leu Glu Ala Pro Ala Ala Pro Ala Ala Val Pro Ser Ala 
            100                 105                 110         


Pro Ala Phe Ser Cys Ser Asp Leu Leu Asn Cys Ala Leu Ser Leu Lys 
        115                 120                 125             


Gly Asp Leu Ala Arg Asp Ala Leu Pro Leu Gln Gln Tyr Lys Leu Val 
    130                 135                 140                 


Arg Pro Arg Val Val Asn His Ser Ser Phe His Ala Met Gly Ala Leu 
145                 150                 155                 160 


Cys Tyr Leu Asn Arg Gly Asp Gly Pro Cys His Pro Ala Ala Gly Val 
                165                 170                 175     


Asn Ile His Pro Val Ala Ser Tyr Phe Leu Ser Ser Pro Leu His Pro 
            180                 185                 190         


Gln Pro Lys Thr Tyr Leu Ala Glu Arg Asn Lys Leu Val Val Pro Ala 
        195                 200                 205             


Val Glu Lys Tyr Pro Ser Gly Val Ala Phe Lys Asp Leu Ser Gln Ala 
    210                 215                 220                 


Gln Leu Gln His Tyr Met Lys Glu Ser Ala Gln Leu Leu Ser Glu Lys 
225                 230                 235                 240 


Ile Ala Phe Lys Thr Ser Asp Phe Ser Arg Gly Ser Pro Asn Ala Lys 
                245                 250                 255     


Pro Lys Val Phe Thr Cys Glu Val Cys Gly Lys Val Phe Asn Ala His 
            260                 265                 270         


Tyr Asn Leu Thr Arg His Met Pro Val His Thr Gly Ala Arg Pro Phe 
        275                 280                 285             


Val Cys Lys Val Cys Gly Lys Gly Phe Arg Gln Ala Ser Thr Leu Cys 
    290                 295                 300                 


Arg His Lys Ile Ile His Thr Gln Glu Lys Pro His Lys Cys Asn Gln 
305                 310                 315                 320 


Cys Gly Lys Ala Phe Asn Arg Ser Ser Thr Leu Asn Thr His Thr Arg 
                325                 330                 335     


Ile His Ala Gly Tyr Lys Pro Phe Val Cys Glu Phe Cys Gly Lys Gly 
            340                 345                 350         


Phe His Gln Lys Gly Asn Tyr Lys Asn His Lys Leu Thr His Ser Gly 
        355                 360                 365             


Glu Lys Gln Phe Lys Cys Asn Ile Cys Asn Lys Ala Phe His Gln Val 
    370                 375                 380                 


Tyr Asn Leu Thr Phe His Met His Thr His Asn Asp Lys Lys Pro Phe 
385                 390                 395                 400 


Thr Cys Pro Thr Cys Gly Lys Gly Phe Cys Arg Asn Phe Asp Leu Lys 
                405                 410                 415     


Lys His Val Arg Lys Leu His Asp Ser Ser Leu Gly Leu Ala Arg Thr 
            420                 425                 430         


Pro Ala Gly Glu Pro Gly Thr Glu Pro Pro Pro Pro Leu Pro Gln Gln 
        435                 440                 445             


Pro Pro Met Thr Leu Pro Pro Leu Gln Pro Pro Leu Pro Thr Pro Gly 
    450                 455                 460                 


Pro Leu Gln Pro Gly Leu His Gln Gly His Gln 
465                 470                 475 


<210>  3997
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FEZF2__Homo_sapiens__NP_060478

<400>  3997

Met Ala Ser Ser Ala Ser Leu Glu Thr Met Val Pro Pro Ala Cys Pro 
1               5                   10                  15      


Arg Ala Gly Ala Ser Pro Ala Thr Ser Lys Thr Leu Ala Phe Ser Ile 
            20                  25                  30          


Glu Arg Ile Met Ala Lys Thr Ser Glu Pro Arg Ala Pro Phe Glu Pro 
        35                  40                  45              


Arg Pro Gly Ala Leu Glu Ala Asp Gly Ser Gln Gly Lys Lys Leu Leu 
    50                  55                  60                  


Asn Leu Cys Ser Pro Leu Pro Cys Met Ile Pro Leu Gln Pro Leu Gly 
65                  70                  75                  80  


Tyr Glu Val Pro Ser Lys Thr Leu Leu Ser Tyr Ser Glu Leu Trp Lys 
                85                  90                  95      


Ser Ser Leu Arg Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Gly Ala Pro Val Cys Gly Ala Ser Gly Leu Cys Lys 
        115                 120                 125             


Thr Asn Cys Gly Val Cys Cys Lys Ala Glu Leu Gly Leu Ala Pro Ser 
    130                 135                 140                 


Ala Leu Pro Ala Gly Arg Val Ile Lys Pro Gln Val Ile Asn Gln Ala 
145                 150                 155                 160 


Val Gly Leu Pro Ala Ser Gly Ser Leu Tyr Tyr Phe Asn Tyr Leu Asp 
                165                 170                 175     


Ser Thr Ala Tyr Pro Pro Ser Glu Leu Leu Ser Gly His Leu Phe Pro 
            180                 185                 190         


Ser Gly Leu Leu Asn Ala Gln Ala Pro Ala Ala Leu Ala Ala His Pro 
        195                 200                 205             


Lys Leu Phe Leu Leu Glu Asn Ala Lys Leu Ala Gly Leu Ala Ala Asp 
    210                 215                 220                 


Lys Phe Pro His Pro Ala Pro Tyr Pro His Lys Glu Arg Leu Pro Ala 
225                 230                 235                 240 


Pro Leu Glu Gln Val Leu Lys Glu Asn Ser Ala Leu Thr Ala Glu Arg 
                245                 250                 255     


Gly Gly Val Lys Gly His Ser Lys Leu Pro Gly Gly Ser Ala Asp Gly 
            260                 265                 270         


Lys Pro Lys Asn Phe Thr Cys Glu Val Cys Gly Lys Val Phe Asn Ala 
        275                 280                 285             


His Tyr Asn Leu Thr Arg His Met Pro Val His Thr Gly Ala Arg Pro 
    290                 295                 300                 


Phe Val Cys Lys Val Cys Gly Lys Gly Phe Arg Gln Ala Ser Thr Leu 
305                 310                 315                 320 


Cys Arg His Lys Ile Ile His Thr Gln Glu Lys Pro His Lys Cys Asn 
                325                 330                 335     


Gln Cys Gly Lys Ala Phe Asn Arg Ser Ser Thr Leu Asn Thr His Ile 
            340                 345                 350         


Arg Ile His Ala Gly Tyr Lys Pro Phe Val Cys Glu Phe Cys Gly Lys 
        355                 360                 365             


Gly Phe His Gln Lys Gly Asn Tyr Lys Asn His Lys Leu Thr His Ser 
    370                 375                 380                 


Gly Glu Lys Gln Tyr Lys Cys Thr Ile Cys Asn Lys Ala Phe His Gln 
385                 390                 395                 400 


Val Tyr Asn Leu Thr Phe His Met His Thr His Asn Asp Lys Lys Pro 
                405                 410                 415     


Phe Thr Cys Ala Thr Cys Gly Lys Gly Phe Cys Arg Asn Phe Asp Leu 
            420                 425                 430         


Lys Lys His Val Arg Lys Leu His Asp Ser Val Gly Pro Ala Ala Pro 
        435                 440                 445             


Ser Ala Lys Asp Leu Thr Arg Thr Val Gln Ser 
    450                 455                 


<210>  3998
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FFAR1__Homo_sapiens__NP_005294

<400>  3998

Met Asp Leu Pro Pro Gln Leu Ser Phe Gly Leu Tyr Val Ala Ala Phe 
1               5                   10                  15      


Ala Leu Gly Phe Pro Leu Asn Val Leu Ala Ile Arg Gly Ala Thr Ala 
            20                  25                  30          


His Ala Arg Leu Arg Leu Thr Pro Ser Leu Val Tyr Ala Leu Asn Leu 
        35                  40                  45              


Gly Cys Ser Asp Leu Leu Leu Thr Val Ser Leu Pro Leu Lys Ala Val 
    50                  55                  60                  


Glu Ala Leu Ala Ser Gly Ala Trp Pro Leu Pro Ala Ser Leu Cys Pro 
65                  70                  75                  80  


Val Phe Ala Val Ala His Phe Phe Pro Leu Tyr Ala Gly Gly Gly Phe 
                85                  90                  95      


Leu Ala Ala Leu Ser Ala Gly Arg Tyr Leu Gly Ala Ala Phe Pro Leu 
            100                 105                 110         


Gly Tyr Gln Ala Phe Arg Arg Pro Cys Tyr Ser Trp Gly Val Cys Ala 
        115                 120                 125             


Ala Ile Trp Ala Leu Val Leu Cys His Leu Gly Leu Val Phe Gly Leu 
    130                 135                 140                 


Glu Ala Pro Gly Gly Trp Leu Asp His Ser Asn Thr Ser Leu Gly Ile 
145                 150                 155                 160 


Asn Thr Pro Val Asn Gly Ser Pro Val Cys Leu Glu Ala Trp Asp Pro 
                165                 170                 175     


Ala Ser Ala Gly Pro Ala Arg Phe Ser Leu Ser Leu Leu Leu Phe Phe 
            180                 185                 190         


Leu Pro Leu Ala Ile Thr Ala Phe Cys Tyr Val Gly Cys Leu Arg Ala 
        195                 200                 205             


Leu Ala Arg Ser Gly Leu Thr His Arg Arg Lys Leu Arg Ala Ala Trp 
    210                 215                 220                 


Val Ala Gly Gly Ala Leu Leu Thr Leu Leu Leu Cys Val Gly Pro Tyr 
225                 230                 235                 240 


Asn Ala Ser Asn Val Ala Ser Phe Leu Tyr Pro Asn Leu Gly Gly Ser 
                245                 250                 255     


Trp Arg Lys Leu Gly Leu Ile Thr Gly Ala Trp Ser Val Val Leu Asn 
            260                 265                 270         


Pro Leu Val Thr Gly Tyr Leu Gly Arg Gly Pro Gly Leu Lys Thr Val 
        275                 280                 285             


Cys Ala Ala Arg Thr Gln Gly Gly Lys Ser Gln Lys 
    290                 295                 300 


<210>  3999
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FFAR2__Homo_sapiens__NP_005297

<400>  3999

Met Leu Pro Asp Trp Lys Ser Ser Leu Ile Leu Met Ala Tyr Ile Ile 
1               5                   10                  15      


Ile Phe Leu Thr Gly Leu Pro Ala Asn Leu Leu Ala Leu Arg Ala Phe 
            20                  25                  30          


Val Gly Arg Ile Arg Gln Pro Gln Pro Ala Pro Val His Ile Leu Leu 
        35                  40                  45              


Leu Ser Leu Thr Leu Ala Asp Leu Leu Leu Leu Leu Leu Leu Pro Phe 
    50                  55                  60                  


Lys Ile Ile Glu Ala Ala Ser Asn Phe Arg Trp Tyr Leu Pro Lys Val 
65                  70                  75                  80  


Val Cys Ala Leu Thr Ser Phe Gly Phe Tyr Ser Ser Ile Tyr Cys Ser 
                85                  90                  95      


Thr Trp Leu Leu Ala Gly Ile Ser Ile Glu Arg Tyr Leu Gly Val Ala 
            100                 105                 110         


Phe Pro Val Gln Tyr Lys Leu Ser Arg Arg Pro Leu Tyr Gly Val Ile 
        115                 120                 125             


Ala Ala Leu Val Ala Trp Val Met Ser Phe Gly His Cys Thr Ile Val 
    130                 135                 140                 


Ile Ile Val Gln Tyr Leu Asn Thr Thr Glu Gln Val Arg Ser Gly Asn 
145                 150                 155                 160 


Glu Ile Thr Cys Tyr Glu Asn Phe Thr Asp Asn Gln Leu Asp Val Val 
                165                 170                 175     


Leu Pro Val Arg Leu Glu Leu Cys Leu Val Leu Phe Phe Ile Pro Met 
            180                 185                 190         


Ala Val Thr Ile Phe Cys Tyr Trp Arg Phe Val Trp Ile Met Leu Ser 
        195                 200                 205             


Gln Pro Leu Val Gly Ala Gln Arg Arg Arg Arg Ala Val Gly Leu Ala 
    210                 215                 220                 


Val Val Thr Leu Leu Asn Phe Leu Val Cys Phe Gly Pro Tyr Asn Val 
225                 230                 235                 240 


Ser His Leu Val Gly Tyr His Gln Arg Lys Ser Pro Trp Trp Arg Ser 
                245                 250                 255     


Ile Ala Val Val Phe Ser Ser Leu Asn Ala Ser Leu Asp Pro Leu Leu 
            260                 265                 270         


Phe Tyr Phe Ser Ser Ser Val Val Arg Arg Ala Phe Gly Arg Gly Leu 
        275                 280                 285             


Gln Val Leu Arg Asn Gln Gly Ser Ser Leu Leu Gly Arg Arg Gly Lys 
    290                 295                 300                 


Asp Thr Ala Glu Gly Thr Asn Glu Asp Arg Gly Val Gly Gln Gly Glu 
305                 310                 315                 320 


Gly Met Pro Ser Ser Asp Phe Thr Thr Glu 
                325                 330 


<210>  4000
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FFAR3__Homo_sapiens__NP_005295

<400>  4000

Met Asp Thr Gly Pro Asp Gln Ser Tyr Phe Ser Gly Asn His Trp Phe 
1               5                   10                  15      


Val Phe Ser Val Tyr Leu Leu Thr Phe Leu Val Gly Leu Pro Leu Asn 
            20                  25                  30          


Leu Leu Ala Leu Val Val Phe Val Gly Lys Leu Gln Arg Arg Pro Val 
        35                  40                  45              


Ala Val Asp Val Leu Leu Leu Asn Leu Thr Ala Ser Asp Leu Leu Leu 
    50                  55                  60                  


Leu Leu Phe Leu Pro Phe Arg Met Val Glu Ala Ala Asn Gly Met His 
65                  70                  75                  80  


Trp Pro Leu Pro Phe Ile Leu Cys Pro Leu Ser Gly Phe Ile Phe Phe 
                85                  90                  95      


Thr Thr Ile Tyr Leu Thr Ala Leu Phe Leu Ala Ala Val Ser Ile Glu 
            100                 105                 110         


Arg Phe Leu Ser Val Ala His Pro Leu Trp Tyr Lys Thr Arg Pro Arg 
        115                 120                 125             


Leu Gly Gln Ala Gly Leu Val Ser Val Ala Cys Trp Leu Leu Ala Ser 
    130                 135                 140                 


Ala His Cys Ser Val Val Tyr Val Ile Glu Phe Ser Gly Asp Ile Ser 
145                 150                 155                 160 


His Ser Gln Gly Thr Asn Gly Thr Cys Tyr Leu Glu Phe Arg Lys Asp 
                165                 170                 175     


Gln Leu Ala Ile Leu Leu Pro Val Arg Leu Glu Met Ala Val Val Leu 
            180                 185                 190         


Phe Val Val Pro Leu Ile Ile Thr Ser Tyr Cys Tyr Ser Arg Leu Val 
        195                 200                 205             


Trp Ile Leu Gly Arg Gly Gly Ser His Arg Arg Gln Arg Arg Val Ala 
    210                 215                 220                 


Gly Leu Leu Ala Ala Thr Leu Leu Asn Phe Leu Val Cys Phe Gly Pro 
225                 230                 235                 240 


Tyr Asn Val Ser His Val Val Gly Tyr Ile Cys Gly Glu Ser Pro Ala 
                245                 250                 255     


Trp Arg Ile Tyr Val Thr Leu Leu Ser Thr Leu Asn Ser Cys Val Asp 
            260                 265                 270         


Pro Phe Val Tyr Tyr Phe Ser Ser Ser Gly Phe Gln Ala Asp Phe His 
        275                 280                 285             


Glu Leu Leu Arg Arg Leu Cys Gly Leu Trp Gly Gln Trp Gln Gln Glu 
    290                 295                 300                 


Ser Ser Met Glu Leu Lys Glu Gln Lys Gly Gly Glu Glu Gln Arg Ala 
305                 310                 315                 320 


Asp Arg Pro Ala Glu Arg Lys Thr Ser Glu His Ser Gln Gly Cys Gly 
                325                 330                 335     


Thr Gly Gly Gln Val Ala Cys Ala Glu Ser 
            340                 345     


<210>  4001
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FFAR4__Homo_sapiens__NP_001182684

<400>  4001

Met Ser Pro Glu Cys Ala Arg Ala Ala Gly Asp Ala Pro Leu Arg Ser 
1               5                   10                  15      


Leu Glu Gln Ala Asn Arg Thr Arg Phe Pro Phe Phe Ser Asp Val Lys 
            20                  25                  30          


Gly Asp His Arg Leu Val Leu Ala Ala Val Glu Thr Thr Val Leu Val 
        35                  40                  45              


Leu Ile Phe Ala Val Ser Leu Leu Gly Asn Val Cys Ala Leu Val Leu 
    50                  55                  60                  


Val Ala Arg Arg Arg Arg Arg Gly Ala Thr Ala Cys Leu Val Leu Asn 
65                  70                  75                  80  


Leu Phe Cys Ala Asp Leu Leu Phe Ile Ser Ala Ile Pro Leu Val Leu 
                85                  90                  95      


Ala Val Arg Trp Thr Glu Ala Trp Leu Leu Gly Pro Val Ala Cys His 
            100                 105                 110         


Leu Leu Phe Tyr Val Met Thr Leu Ser Gly Ser Val Thr Ile Leu Thr 
        115                 120                 125             


Leu Ala Ala Val Ser Leu Glu Arg Met Val Cys Ile Val His Leu Gln 
    130                 135                 140                 


Arg Gly Val Arg Gly Pro Gly Arg Arg Ala Arg Ala Val Leu Leu Ala 
145                 150                 155                 160 


Leu Ile Trp Gly Tyr Ser Ala Val Ala Ala Leu Pro Leu Cys Val Phe 
                165                 170                 175     


Phe Arg Val Val Pro Gln Arg Leu Pro Gly Ala Asp Gln Glu Ile Ser 
            180                 185                 190         


Ile Cys Thr Leu Ile Trp Pro Thr Ile Pro Gly Glu Ile Ser Trp Asp 
        195                 200                 205             


Val Ser Phe Val Thr Leu Asn Phe Leu Val Pro Gly Leu Val Ile Val 
    210                 215                 220                 


Ile Ser Tyr Ser Lys Ile Leu Gln Ile Thr Lys Ala Ser Arg Lys Arg 
225                 230                 235                 240 


Leu Thr Val Ser Leu Ala Tyr Ser Glu Ser His Gln Ile Arg Val Ser 
                245                 250                 255     


Gln Gln Asp Phe Arg Leu Phe Arg Thr Leu Phe Leu Leu Met Val Ser 
            260                 265                 270         


Phe Phe Ile Met Trp Ser Pro Ile Ile Ile Thr Ile Leu Leu Ile Leu 
        275                 280                 285             


Ile Gln Asn Phe Lys Gln Asp Leu Val Ile Trp Pro Ser Leu Phe Phe 
    290                 295                 300                 


Trp Val Val Ala Phe Thr Phe Ala Asn Ser Ala Leu Asn Pro Ile Leu 
305                 310                 315                 320 


Tyr Asn Met Thr Leu Cys Arg Asn Glu Trp Lys Lys Ile Phe Cys Cys 
                325                 330                 335     


Phe Trp Phe Pro Glu Lys Gly Ala Ile Leu Thr Asp Thr Ser Val Lys 
            340                 345                 350         


Arg Asn Asp Leu Ser Ile Ile Ser Gly 
        355                 360     


<210>  4002
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGA__Homo_sapiens__NP_000499

<400>  4002

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  4003
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGB__Homo_sapiens__NP_005132

<400>  4003

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210>  4004
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGD1__Homo_sapiens__NP_004454

<400>  4004

Met His Gly His Arg Ala Pro Gly Gly Ala Gly Pro Ser Glu Pro Glu 
1               5                   10                  15      


His Pro Ala Thr Asn Pro Pro Gly Ala Ala Pro Pro Ala Cys Ala Asp 
            20                  25                  30          


Ser Asp Pro Gly Ala Ser Glu Pro Gly Leu Leu Ala Arg Arg Gly Ser 
        35                  40                  45              


Gly Ser Ala Leu Gly Gly Pro Leu Asp Pro Gln Phe Val Gly Pro Ser 
    50                  55                  60                  


Asp Thr Ser Leu Gly Ala Ala Pro Gly His Arg Val Leu Pro Cys Gly 
65                  70                  75                  80  


Pro Ser Pro Gln His His Arg Ala Leu Arg Phe Ser Tyr His Leu Glu 
                85                  90                  95      


Gly Ser Gln Pro Arg Pro Gly Leu His Gln Gly Asn Arg Ile Leu Val 
            100                 105                 110         


Lys Ser Leu Ser Leu Asp Pro Gly Gln Ser Leu Glu Pro His Pro Glu 
        115                 120                 125             


Gly Pro Gln Arg Leu Arg Ser Asp Pro Gly Pro Pro Thr Glu Thr Pro 
    130                 135                 140                 


Ser Gln Arg Pro Ser Pro Leu Lys Arg Ala Pro Gly Pro Lys Pro Gln 
145                 150                 155                 160 


Val Pro Pro Lys Pro Ser Tyr Leu Gln Met Pro Arg Met Pro Pro Pro 
                165                 170                 175     


Leu Glu Pro Ile Pro Pro Pro Pro Ser Arg Pro Leu Pro Ala Asp Pro 
            180                 185                 190         


Arg Val Ala Lys Gly Leu Ala Pro Arg Ala Glu Ala Ser Pro Ser Ser 
        195                 200                 205             


Ala Ala Val Ser Ser Leu Ile Glu Lys Phe Glu Arg Glu Pro Val Ile 
    210                 215                 220                 


Val Ala Ser Asp Arg Pro Val Pro Gly Pro Ser Pro Gly Pro Pro Glu 
225                 230                 235                 240 


Pro Val Met Leu Pro Gln Pro Thr Ser Gln Pro Pro Val Pro Gln Leu 
                245                 250                 255     


Pro Glu Gly Glu Ala Ser Arg Cys Leu Phe Leu Leu Ala Pro Gly Pro 
            260                 265                 270         


Arg Asp Gly Glu Lys Val Pro Asn Arg Asp Ser Gly Ile Asp Ser Ile 
        275                 280                 285             


Ser Ser Pro Ser Asn Ser Glu Glu Thr Cys Phe Val Ser Asp Asp Gly 
    290                 295                 300                 


Pro Pro Ser His Ser Leu Cys Pro Gly Pro Pro Ala Leu Ala Ser Val 
305                 310                 315                 320 


Pro Val Ala Leu Ala Asp Pro His Arg Pro Gly Ser Gln Glu Val Asp 
                325                 330                 335     


Ser Asp Leu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu Lys Asp 
            340                 345                 350         


Arg Glu Ile Pro Val Pro Leu Met Glu Arg Gln Glu Ser Val Glu Leu 
        355                 360                 365             


Thr Val Gln Gln Lys Val Phe His Ile Ala Asn Glu Leu Leu Gln Thr 
    370                 375                 380                 


Glu Lys Ala Tyr Val Ser Arg Leu His Leu Leu Asp Gln Val Phe Cys 
385                 390                 395                 400 


Ala Arg Leu Leu Glu Glu Ala Arg Asn Arg Ser Ser Phe Pro Ala Asp 
                405                 410                 415     


Val Val His Gly Ile Phe Ser Asn Ile Cys Ser Ile Tyr Cys Phe His 
            420                 425                 430         


Gln Gln Phe Leu Leu Pro Glu Leu Glu Lys Arg Met Glu Glu Trp Asp 
        435                 440                 445             


Arg Tyr Pro Arg Ile Gly Asp Ile Leu Gln Lys Leu Ala Pro Phe Leu 
    450                 455                 460                 


Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg Ala Val Glu Leu 
465                 470                 475                 480 


Val Asn Thr Trp Thr Glu Arg Ser Thr Gln Phe Lys Val Ile Ile His 
                485                 490                 495     


Glu Val Gln Lys Glu Glu Ala Cys Gly Asn Leu Thr Leu Gln His His 
            500                 505                 510         


Met Leu Glu Pro Val Gln Arg Ile Pro Arg Tyr Glu Leu Leu Leu Lys 
        515                 520                 525             


Asp Tyr Leu Leu Lys Leu Pro His Gly Ser Pro Asp Ser Lys Asp Ala 
    530                 535                 540                 


Gln Lys Ser Leu Glu Leu Ile Ala Thr Ala Ala Glu His Ser Asn Ala 
545                 550                 555                 560 


Ala Ile Arg Lys Met Glu Arg Met His Lys Leu Leu Lys Val Tyr Glu 
                565                 570                 575     


Leu Leu Gly Gly Glu Glu Asp Ile Val Ser Pro Thr Lys Glu Leu Ile 
            580                 585                 590         


Lys Glu Gly His Ile Leu Lys Leu Ser Ala Lys Asn Gly Thr Thr Gln 
        595                 600                 605             


Asp Arg Tyr Leu Ile Leu Phe Asn Asp Arg Leu Leu Tyr Cys Val Pro 
    610                 615                 620                 


Arg Leu Arg Leu Leu Gly Gln Lys Phe Ser Val Arg Ala Arg Ile Asp 
625                 630                 635                 640 


Val Asp Gly Met Glu Leu Lys Glu Ser Ser Asn Leu Asn Leu Pro Arg 
                645                 650                 655     


Thr Phe Leu Val Ser Gly Lys Gln Arg Ser Leu Glu Leu Gln Ala Arg 
            660                 665                 670         


Thr Glu Glu Glu Lys Lys Asp Trp Val Gln Ala Ile Asn Ser Thr Leu 
        675                 680                 685             


Leu Lys His Glu Gln Thr Leu Glu Thr Phe Lys Leu Leu Asn Ser Thr 
    690                 695                 700                 


Asn Arg Glu Asp Glu Asp Thr Pro Pro Asn Ser Pro Asn Val Asp Leu 
705                 710                 715                 720 


Gly Lys Arg Ala Pro Thr Pro Ile Arg Glu Lys Glu Val Thr Met Cys 
                725                 730                 735     


Met Arg Cys Gln Glu Pro Phe Asn Ser Ile Thr Lys Arg Arg His His 
            740                 745                 750         


Cys Lys Ala Cys Gly His Val Val Cys Gly Lys Cys Ser Glu Phe Arg 
        755                 760                 765             


Ala Arg Leu Val Tyr Asp Asn Asn Arg Ser Asn Arg Val Cys Thr Asp 
    770                 775                 780                 


Cys Tyr Val Ala Leu His Gly Val Pro Gly Ser Ser Pro Ala Cys Ser 
785                 790                 795                 800 


Gln His Thr Pro Gln Arg Arg Arg Ser Ile Leu Glu Lys Gln Ala Ser 
                805                 810                 815     


Val Ala Ala Glu Asn Ser Val Ile Cys Ser Phe Leu His Tyr Met Glu 
            820                 825                 830         


Lys Gly Gly Lys Gly Trp His Lys Ala Trp Phe Val Val Pro Glu Asn 
        835                 840                 845             


Glu Pro Leu Val Leu Tyr Ile Tyr Gly Ala Pro Gln Asp Val Lys Ala 
    850                 855                 860                 


Gln Arg Ser Leu Pro Leu Ile Gly Phe Glu Val Gly Pro Pro Glu Ala 
865                 870                 875                 880 


Gly Glu Arg Pro Asp Arg Arg His Val Phe Lys Ile Thr Gln Ser His 
                885                 890                 895     


Leu Ser Trp Tyr Phe Ser Pro Glu Thr Glu Glu Leu Gln Arg Arg Trp 
            900                 905                 910         


Met Ala Val Leu Gly Arg Ala Gly Arg Gly Asp Thr Phe Cys Pro Gly 
        915                 920                 925             


Pro Thr Leu Ser Glu Asp Arg Glu Met Glu Glu Ala Pro Val Ala Ala 
    930                 935                 940                 


Leu Gly Ala Thr Ala Glu Pro Pro Glu Ser Pro Gln Thr Arg Asp Lys 
945                 950                 955                 960 


Thr 
    


<210>  4005
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGD2__Homo_sapiens__NP_775829

<400>  4005

Met Lys Gly Ala Ser Glu Glu Lys Leu Ala Ser Val Ser Asn Leu Val 
1               5                   10                  15      


Thr Val Phe Glu Asn Ser Arg Thr Pro Glu Ala Ala Pro Arg Gly Gln 
            20                  25                  30          


Arg Leu Glu Asp Val His His Arg Pro Glu Cys Arg Pro Pro Glu Ser 
        35                  40                  45              


Pro Gly Pro Arg Glu Lys Thr Asn Val Gly Glu Ala Val Gly Ser Glu 
    50                  55                  60                  


Pro Arg Thr Val Ser Arg Arg Tyr Leu Asn Ser Leu Lys Asn Lys Leu 
65                  70                  75                  80  


Ser Ser Glu Ala Trp Arg Lys Ser Cys Gln Pro Val Thr Leu Ser Gly 
                85                  90                  95      


Ser Gly Thr Gln Glu Pro Glu Lys Lys Ile Val Gln Glu Leu Leu Glu 
            100                 105                 110         


Thr Glu Gln Ala Tyr Val Ala Arg Leu His Leu Leu Asp Gln Val Phe 
        115                 120                 125             


Phe Gln Glu Leu Leu Lys Thr Ala Arg Ser Ser Lys Ala Phe Pro Glu 
    130                 135                 140                 


Asp Val Val Arg Val Ile Phe Ser Asn Ile Ser Ser Ile Tyr Gln Phe 
145                 150                 155                 160 


His Ser Gln Phe Phe Leu Pro Glu Leu Gln Arg Arg Leu Asp Asp Trp 
                165                 170                 175     


Thr Ala Asn Pro Arg Ile Gly Asp Val Ile Gln Lys Leu Ala Pro Phe 
            180                 185                 190         


Leu Lys Met Tyr Ser Glu Tyr Val Lys Asn Phe Glu Arg Ala Ala Glu 
        195                 200                 205             


Leu Leu Ala Thr Trp Thr Asp Lys Ser Pro Leu Phe Gln Glu Val Leu 
    210                 215                 220                 


Thr Arg Ile Gln Ser Ser Glu Ala Ser Gly Ser Leu Thr Leu Gln His 
225                 230                 235                 240 


His Met Leu Glu Pro Val Gln Arg Ile Pro Arg Tyr Glu Leu Leu Leu 
                245                 250                 255     


Lys Glu Tyr Ile Gln Lys Leu Pro Ala Gln Ala Pro Asp Gln Ala Asp 
            260                 265                 270         


Ala Gln Lys Ala Leu Asp Met Ile Phe Ser Ala Ala Gln His Ser Asn 
        275                 280                 285             


Ala Ala Ile Thr Glu Met Glu Arg Leu Gln Asp Leu Trp Glu Val Tyr 
    290                 295                 300                 


Gln Arg Leu Gly Leu Glu Asp Asp Ile Val Asp Pro Ser Asn Thr Leu 
305                 310                 315                 320 


Leu Arg Glu Gly Pro Val Leu Lys Ile Ser Phe Arg Arg Asn Asp Pro 
                325                 330                 335     


Met Glu Arg Tyr Leu Phe Leu Phe Asn Asn Met Leu Leu Tyr Cys Val 
            340                 345                 350         


Pro Arg Val Ile Gln Val Gly Ala Gln Phe Gln Val Arg Thr Arg Ile 
        355                 360                 365             


Asp Val Ala Gly Met Lys Val Arg Glu Leu Met Asp Ala Glu Phe Pro 
    370                 375                 380                 


His Ser Phe Leu Val Ser Gly Lys Gln Arg Thr Leu Glu Leu Gln Ala 
385                 390                 395                 400 


Arg Ser Gln Glu Glu Met Ile Ser Trp Met Gln Ala Phe Gln Ala Ala 
                405                 410                 415     


Ile Asp Gln Ile Glu Lys Arg Asn Glu Thr Phe Lys Ala Ala Ala Gln 
            420                 425                 430         


Gly Pro Glu Gly Asp Ile Gln Glu Gln Glu Leu Gln Ser Glu Glu Leu 
        435                 440                 445             


Gly Leu Arg Ala Pro Gln Trp Val Arg Asp Lys Met Val Thr Met Cys 
    450                 455                 460                 


Met Arg Cys Gln Glu Pro Phe Asn Ala Leu Thr Arg Arg Arg His His 
465                 470                 475                 480 


Cys Arg Ala Cys Gly Tyr Val Val Cys Ala Arg Cys Ser Asp Tyr Arg 
                485                 490                 495     


Ala Glu Leu Lys Tyr Asp Asp Asn Arg Pro Asn Arg Val Cys Leu His 
            500                 505                 510         


Cys Tyr Ala Phe Leu Thr Gly Asn Val Leu Pro Glu Ala Lys Glu Asp 
        515                 520                 525             


Lys Arg Arg Gly Ile Leu Glu Lys Gly Ser Ser Ala Thr Pro Asp Gln 
    530                 535                 540                 


Ser Leu Met Cys Ser Phe Leu Gln Leu Ile Gly Asp Lys Trp Gly Lys 
545                 550                 555                 560 


Ser Gly Pro Arg Gly Trp Cys Val Ile Pro Arg Asp Asp Pro Leu Val 
                565                 570                 575     


Leu Tyr Val Tyr Ala Ala Pro Gln Asp Met Arg Ala His Thr Ser Ile 
            580                 585                 590         


Pro Leu Leu Gly Tyr Gln Val Thr Val Gly Pro Gln Gly Asp Pro Arg 
        595                 600                 605             


Val Phe Gln Leu Gln Gln Ser Gly Gln Leu Tyr Thr Phe Lys Ala Glu 
    610                 615                 620                 


Thr Glu Glu Leu Lys Gly Arg Trp Val Lys Ala Met Glu Arg Ala Ala 
625                 630                 635                 640 


Ser Gly Trp Ser Pro Ser Trp Pro Asn Asp Gly Asp Leu Ser Asp 
                645                 650                 655 


<210>  4006
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGD3__Homo_sapiens__NP_001077005

<400>  4006

Met Glu Ser Gly Arg Gly Ser Ser Thr Pro Pro Gly Pro Ile Ala Ala 
1               5                   10                  15      


Leu Gly Met Pro Asp Thr Gly Pro Gly Ser Ser Ser Leu Gly Lys Leu 
            20                  25                  30          


Gln Ala Leu Pro Val Gly Pro Arg Ala His Cys Gly Asp Pro Val Ser 
        35                  40                  45              


Leu Ala Ala Ala Gly Asp Gly Ser Pro Asp Ile Gly Pro Thr Gly Glu 
    50                  55                  60                  


Leu Ser Gly Ser Leu Lys Ile Pro Asn Arg Asp Ser Gly Ile Asp Ser 
65                  70                  75                  80  


Pro Ser Ser Ser Val Ala Gly Glu Asn Phe Pro Cys Glu Glu Gly Leu 
                85                  90                  95      


Glu Ala Gly Pro Ser Pro Thr Val Leu Gly Ala His Ala Glu Met Ala 
            100                 105                 110         


Leu Asp Ser Gln Val Pro Lys Val Thr Pro Gln Glu Glu Ala Asp Ser 
        115                 120                 125             


Asp Val Gly Glu Glu Pro Asp Ser Glu Asn Thr Pro Gln Lys Ala Asp 
    130                 135                 140                 


Lys Asp Ala Gly Leu Ala Gln His Ser Gly Pro Gln Lys Leu Leu His 
145                 150                 155                 160 


Ile Ala Gln Glu Leu Leu His Thr Glu Glu Thr Tyr Val Lys Arg Leu 
                165                 170                 175     


His Leu Leu Asp Gln Val Phe Cys Thr Arg Leu Thr Asp Ala Gly Ile 
            180                 185                 190         


Pro Pro Glu Val Ile Met Gly Ile Phe Ser Asn Ile Ser Ser Ile His 
        195                 200                 205             


Arg Phe His Gly Gln Phe Leu Leu Pro Glu Leu Lys Thr Arg Ile Thr 
    210                 215                 220                 


Glu Glu Trp Asp Thr Asn Pro Arg Leu Gly Asp Ile Leu Gln Lys Leu 
225                 230                 235                 240 


Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg 
                245                 250                 255     


Ala Val Gly Leu Val Ser Thr Trp Thr Gln Arg Ser Pro Leu Phe Lys 
            260                 265                 270         


Asp Val Val His Ser Ile Gln Lys Gln Glu Val Cys Gly Asn Leu Thr 
        275                 280                 285             


Leu Gln His His Met Leu Glu Pro Val Gln Arg Val Pro Arg Tyr Glu 
    290                 295                 300                 


Leu Leu Leu Lys Asp Tyr Leu Lys Arg Leu Pro Gln Asp Ala Pro Asp 
305                 310                 315                 320 


Arg Lys Asp Ala Glu Arg Ser Leu Glu Leu Ile Ser Thr Ala Ala Asn 
                325                 330                 335     


His Ser Asn Ala Ala Ile Arg Lys Val Glu Lys Met His Lys Leu Leu 
            340                 345                 350         


Glu Val Tyr Glu Gln Leu Gly Gly Glu Glu Asp Ile Val Asn Pro Ala 
        355                 360                 365             


Asn Glu Leu Ile Lys Glu Gly Gln Ile Gln Lys Leu Ser Ala Lys Asn 
    370                 375                 380                 


Gly Thr Pro Gln Asp Arg His Leu Phe Leu Phe Asn Ser Met Ile Leu 
385                 390                 395                 400 


Tyr Cys Val Pro Lys Leu Arg Leu Met Gly Gln Lys Phe Ser Val Arg 
                405                 410                 415     


Glu Lys Met Asp Ile Ser Gly Leu Gln Val Gln Asp Ile Val Lys Pro 
            420                 425                 430         


Asn Thr Ala His Thr Phe Ile Ile Thr Gly Arg Lys Arg Ser Leu Glu 
        435                 440                 445             


Leu Gln Thr Arg Thr Glu Glu Glu Lys Lys Glu Trp Ile Gln Ile Ile 
    450                 455                 460                 


Gln Ala Thr Ile Glu Lys His Lys Gln Asn Ser Glu Thr Phe Lys Ala 
465                 470                 475                 480 


Phe Gly Gly Ala Phe Ser Gln Asp Glu Asp Pro Ser Leu Ser Pro Asp 
                485                 490                 495     


Met Pro Ile Thr Ser Thr Ser Pro Val Glu Pro Val Val Thr Thr Glu 
            500                 505                 510         


Gly Ser Ser Gly Ala Ala Gly Leu Glu Pro Arg Lys Leu Ser Ser Lys 
        515                 520                 525             


Thr Arg Arg Asp Lys Glu Lys Gln Ser Cys Lys Ser Cys Gly Glu Thr 
    530                 535                 540                 


Phe Asn Ser Ile Thr Lys Arg Arg His His Cys Lys Leu Cys Gly Ala 
545                 550                 555                 560 


Val Ile Cys Gly Lys Cys Ser Glu Phe Lys Ala Glu Asn Ser Arg Gln 
                565                 570                 575     


Ser Arg Val Cys Arg Asp Cys Phe Leu Thr Gln Pro Val Ala Pro Glu 
            580                 585                 590         


Ser Thr Glu Lys Thr Pro Thr Ala Asp Pro Gln Pro Ser Leu Leu Cys 
        595                 600                 605             


Gly Pro Leu Arg Leu Ser Glu Ser Gly Glu Thr Trp Ser Glu Val Trp 
    610                 615                 620                 


Ala Ala Ile Pro Met Ser Asp Pro Gln Val Leu His Leu Gln Gly Gly 
625                 630                 635                 640 


Ser Gln Asp Gly Arg Leu Pro Arg Thr Ile Pro Leu Pro Ser Cys Lys 
                645                 650                 655     


Leu Ser Val Pro Asp Pro Glu Glu Arg Leu Asp Ser Gly His Val Trp 
            660                 665                 670         


Lys Leu Gln Trp Ala Lys Gln Ser Trp Tyr Leu Ser Ala Ser Ser Ala 
        675                 680                 685             


Glu Leu Gln Gln Gln Trp Leu Glu Thr Leu Ser Thr Ala Ala His Gly 
    690                 695                 700                 


Asp Thr Ala Gln Asp Ser Pro Gly Ala Leu Gln Leu Gln Val Pro Met 
705                 710                 715                 720 


Gly Ala Ala Ala Pro 
                725 


<210>  4007
<211>  878
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGD4__Homo_sapiens__NP_001291409

<400>  4007

Met Asn Phe Lys Arg Val Lys Pro Asn Ile Phe Leu Leu Asn Gln Ser 
1               5                   10                  15      


Arg Leu Ile Ile Ser Ile Cys Glu Ile Met Ser Thr Asp Gln Gly Ser 
            20                  25                  30          


Ser Thr Cys Pro Lys Ile Ala Leu Val Pro Pro Cys Ser Thr Ser Ser 
        35                  40                  45              


Thr Thr Thr Leu Val Gly Glu Asn Val Ser Glu Glu Glu Ala Gln Gly 
    50                  55                  60                  


Ile Asn Gly Asn Arg Pro Ala Lys His Ser Ala Ala Ser Pro Lys Pro 
65                  70                  75                  80  


Gln Val Pro Pro Lys Pro Leu His Leu Gln Asn Ser Pro Ser Ser Asn 
                85                  90                  95      


Ile His Gln Thr Pro Arg His Lys Ala Leu Pro Ser Ala Lys Pro Arg 
            100                 105                 110         


Met Glu Glu Ile Lys Pro Ala Ser Ala Ser Cys Val Ser Lys Glu Lys 
        115                 120                 125             


Pro Ser Lys Val Ser Asp Leu Ile Ser Arg Phe Glu Gly Gly Ser Ser 
    130                 135                 140                 


Leu Ser Asn Tyr Ser Asp Leu Lys Lys Glu Ser Ala Val Asn Leu Asn 
145                 150                 155                 160 


Ala Pro Arg Thr Pro Gly Arg His Gly Leu Thr Thr Thr Pro Gln Gln 
                165                 170                 175     


Lys Leu Leu Ser Gln His Leu Pro Gln Arg Gln Gly Asn Asp Thr Asp 
            180                 185                 190         


Lys Thr Gln Gly Ala Gln Thr Cys Val Ala Asn Gly Val Met Ala Ala 
        195                 200                 205             


Gln Asn Gln Met Glu Cys Glu Glu Glu Lys Ala Ala Thr Leu Ser Ser 
    210                 215                 220                 


Asp Thr Ser Ile Gln Ala Ser Glu Pro Leu Leu Asp Thr His Ile Val 
225                 230                 235                 240 


Asn Gly Glu Arg Asp Glu Thr Ala Thr Ala Pro Ala Ser Pro Thr Thr 
                245                 250                 255     


Asp Ser Cys Asp Gly Asn Ala Ser Asp Ser Ser Tyr Arg Thr Pro Gly 
            260                 265                 270         


Ile Gly Pro Val Leu Pro Leu Glu Glu Arg Gly Ala Glu Thr Glu Thr 
        275                 280                 285             


Lys Val Gln Glu Arg Glu Asn Gly Glu Ser Pro Leu Glu Leu Glu Gln 
    290                 295                 300                 


Leu Asp Gln His His Glu Met Lys Glu Thr Asn Glu Gln Lys Leu His 
305                 310                 315                 320 


Lys Ile Ala Asn Glu Leu Leu Leu Thr Glu Arg Ala Tyr Val Asn Arg 
                325                 330                 335     


Leu Asp Leu Leu Asp Gln Val Phe Tyr Cys Lys Leu Leu Glu Glu Ala 
            340                 345                 350         


Asn Arg Gly Ser Phe Pro Ala Glu Met Val Asn Lys Ile Phe Ser Asn 
        355                 360                 365             


Ile Ser Ser Ile Asn Ala Phe His Ser Lys Phe Leu Leu Pro Glu Leu 
    370                 375                 380                 


Glu Lys Arg Met Gln Glu Trp Glu Thr Thr Pro Arg Ile Gly Asp Ile 
385                 390                 395                 400 


Leu Gln Lys Leu Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys 
                405                 410                 415     


Gly Phe Asp Asn Ala Met Glu Leu Val Lys Asn Met Thr Glu Arg Ile 
            420                 425                 430         


Pro Gln Phe Lys Ser Val Val Glu Glu Ile Gln Lys Gln Lys Ile Cys 
        435                 440                 445             


Gly Ser Leu Thr Leu Gln His His Met Leu Glu Pro Val Gln Arg Ile 
    450                 455                 460                 


Pro Arg Tyr Glu Met Leu Leu Lys Asp Tyr Leu Arg Lys Leu Pro Pro 
465                 470                 475                 480 


Asp Ser Leu Asp Trp Asn Asp Ala Lys Lys Ser Leu Glu Ile Ile Ser 
                485                 490                 495     


Thr Ala Ala Ser His Ser Asn Ser Ala Ile Arg Lys Met Glu Asn Leu 
            500                 505                 510         


Lys Lys Leu Leu Glu Ile Tyr Glu Met Leu Gly Glu Glu Glu Asp Ile 
        515                 520                 525             


Val Asn Pro Ser Asn Glu Leu Ile Lys Glu Gly Gln Ile Leu Lys Leu 
    530                 535                 540                 


Ala Ala Arg Asn Thr Ser Ala Gln Glu Arg Tyr Leu Phe Leu Phe Asn 
545                 550                 555                 560 


Asn Met Leu Leu Tyr Cys Val Pro Lys Phe Ser Leu Val Gly Ser Lys 
                565                 570                 575     


Phe Thr Val Arg Thr Arg Val Gly Ile Asp Gly Met Lys Ile Val Glu 
            580                 585                 590         


Thr Gln Asn Glu Glu Tyr Pro His Thr Phe Gln Val Ser Gly Lys Glu 
        595                 600                 605             


Arg Thr Leu Glu Leu Gln Ala Ser Ser Ala Gln Asp Lys Glu Glu Trp 
    610                 615                 620                 


Ile Lys Ala Leu Gln Glu Thr Ile Asp Ala Phe His Gln Arg His Glu 
625                 630                 635                 640 


Thr Phe Arg Asn Ala Ile Ala Lys Asp Asn Asp Ile His Ser Glu Val 
                645                 650                 655     


Ser Thr Ala Glu Leu Gly Lys Arg Ala Pro Arg Trp Ile Arg Asp Asn 
            660                 665                 670         


Glu Val Thr Met Cys Met Lys Cys Lys Glu Pro Phe Asn Ala Leu Thr 
        675                 680                 685             


Arg Arg Arg His His Cys Arg Ala Cys Gly Tyr Val Val Cys Trp Lys 
    690                 695                 700                 


Cys Ser Asp Tyr Lys Ala Gln Leu Glu Tyr Asp Gly Gly Lys Leu Ser 
705                 710                 715                 720 


Lys Val Cys Lys Asp Cys Tyr Gln Ile Ile Ser Gly Phe Thr Asp Ser 
                725                 730                 735     


Glu Glu Lys Lys Arg Lys Gly Ile Leu Glu Ile Glu Ser Ala Glu Val 
            740                 745                 750         


Ser Gly Asn Ser Val Val Cys Ser Phe Leu Gln Tyr Met Glu Lys Ser 
        755                 760                 765             


Lys Pro Trp Gln Lys Ala Trp Cys Val Ile Pro Lys Gln Asp Pro Leu 
    770                 775                 780                 


Val Leu Tyr Met Tyr Gly Ala Pro Gln Asp Val Arg Ala Gln Ala Thr 
785                 790                 795                 800 


Ile Pro Leu Leu Gly Tyr Val Val Asp Glu Met Pro Arg Ser Ala Asp 
                805                 810                 815     


Leu Pro His Ser Phe Lys Leu Thr Gln Ser Lys Ser Val His Ser Phe 
            820                 825                 830         


Ala Ala Asp Ser Glu Glu Leu Lys Gln Lys Trp Leu Lys Val Ile Leu 
        835                 840                 845             


Leu Ala Val Thr Gly Glu Thr Pro Gly Gly Pro Asn Glu His Pro Ala 
    850                 855                 860                 


Thr Leu Asp Asp His Pro Glu Pro Lys Lys Lys Ser Glu Cys 
865                 870                 875             


<210>  4008
<211>  1462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGD5__Homo_sapiens__NP_689749

<400>  4008

Met Phe Arg Gly Pro Lys Pro Pro Ile Ala Pro Lys Pro Arg Leu Thr 
1               5                   10                  15      


Ala Pro Asn Glu Trp Arg Ala Ser Val Tyr Leu Asn Asp Ser Leu Asn 
            20                  25                  30          


Lys Cys Ser Asn Gly Arg Leu Pro Cys Val Asp Arg Gly Leu Asp Glu 
        35                  40                  45              


Gly Pro Arg Ser Ile Pro Lys Cys Ser Glu Ser Glu Thr Asp Glu Asp 
    50                  55                  60                  


Tyr Ile Val Val Pro Arg Val Pro Leu Arg Glu Asp Glu Pro Lys Asp 
65                  70                  75                  80  


Glu Gly Ser Val Gly Asn Lys Ala Leu Val Ser Pro Glu Ser Ser Ala 
                85                  90                  95      


Glu Glu Glu Glu Glu Arg Glu Glu Gly Gly Glu Ala Cys Gly Leu Glu 
            100                 105                 110         


Gly Thr Gly Ala Gly Glu Asp Ser Val Ala Pro Ala Ala Pro Gly Ala 
        115                 120                 125             


Gly Ala Leu Ser Arg Glu Gly Glu Glu Gly Thr Asp Leu Ala Leu Glu 
    130                 135                 140                 


Asp Glu Gly Glu Gly Cys Ala Asp Glu Pro Gly Thr Leu Glu Gln Val 
145                 150                 155                 160 


Ser Arg Ser Glu Glu Glu Glu Lys Leu Val Gln Pro His Arg Glu Cys 
                165                 170                 175     


Ser Leu Glu Asp Ser Gly Pro Trp Ala Gly Glu Gly Val Phe Gln Ser 
            180                 185                 190         


Asp Leu Leu Leu Pro His Ile His Gly Glu Asp Gln Glu Pro Pro Asp 
        195                 200                 205             


Thr Pro Gly Glu Ala Glu Glu Asp Asp Glu Glu Gly Cys Ala Ser Thr 
    210                 215                 220                 


Asp Pro Ala Gly Ala Asp Glu Gly Ser Gly Pro Asp Arg Pro Thr Glu 
225                 230                 235                 240 


Asp Met Gly Gln Asp Ala Glu Asp Thr Ser Glu Glu Pro Pro Glu Lys 
                245                 250                 255     


Glu Glu Leu Ala Gly Val Gln Glu Ala Glu Thr Ala Thr Asp Cys Pro 
            260                 265                 270         


Glu Val Leu Glu Glu Gly Cys Glu Glu Ala Thr Gly Val Thr Gly Gly 
        275                 280                 285             


Glu Gln Val Asp Leu Ser Glu Pro Pro Asp His Glu Lys Lys Thr Asn 
    290                 295                 300                 


Gln Glu Val Ala Ala Ala Thr Leu Glu Asp His Ala Gln Asp Glu Ser 
305                 310                 315                 320 


Ala Glu Glu Ser Cys Gln Ile Val Pro Phe Glu Asn Asp Cys Met Glu 
                325                 330                 335     


Asp Phe Val Thr Ser Leu Thr Gly Ser Pro Tyr Glu Phe Phe Pro Thr 
            340                 345                 350         


Glu Ser Thr Ser Phe Cys Ser Glu Ser Cys Ser Pro Leu Ser Glu Ser 
        355                 360                 365             


Ala Lys Gly Leu Glu Ser Glu Gln Ala Pro Lys Leu Gly Leu Arg Ala 
    370                 375                 380                 


Glu Glu Asn Pro Met Val Gly Ala Leu Cys Gly Gln Cys Gly Ser Leu 
385                 390                 395                 400 


Gln Gly Gly Ala Ala Glu Gly Pro Ala Ala Pro Asp Val Val Val Val 
                405                 410                 415     


Leu Glu Glu Glu Ala Leu Asp Asp Ala Leu Ala Asn Pro Tyr Val Met 
            420                 425                 430         


Gly Val Gly Leu Pro Gly Gln Ala Ala Pro Gly Glu Gly Gly Gln Ala 
        435                 440                 445             


Ala Ser Asp Ala Leu Gly Gly Tyr Gly Ser Lys Glu Glu Leu Asn Cys 
    450                 455                 460                 


Glu Ala Glu Gly Gly Leu Val Pro Ala Asp Arg Lys Asn Thr Ser Thr 
465                 470                 475                 480 


Arg Val Arg Pro His Ser Gly Lys Val Ala Gly Tyr Val Pro Glu Thr 
                485                 490                 495     


Val Pro Glu Glu Thr Gly Pro Glu Ala Gly Ser Ser Ala Pro Gly Ile 
            500                 505                 510         


Gly Gly Ala Ala Glu Glu Val Gly Lys Thr Leu Leu Ser Leu Glu Gly 
        515                 520                 525             


Lys Pro Leu Glu Ala Ser Arg Ala Leu Pro Ala Lys Pro Arg Ala Phe 
    530                 535                 540                 


Thr Leu Tyr Pro Arg Ser Phe Ser Val Glu Gly Arg Glu Ile Pro Val 
545                 550                 555                 560 


Ser Val Tyr Gln Glu Pro Glu Gly Ser Gly Leu Asp Asp His Arg Ile 
                565                 570                 575     


Lys Arg Lys Glu Asp Asn Leu Ser Leu Ser Cys Val Ile Gly Ser Ser 
            580                 585                 590         


Gly Ser Phe Ser Gln Arg Asn His Leu Pro Ser Ser Gly Thr Ser Thr 
        595                 600                 605             


Pro Ser Ser Met Val Asp Ile Pro Pro Pro Phe Asp Leu Ala Cys Ile 
    610                 615                 620                 


Thr Lys Lys Pro Ile Thr Lys Ser Ser Pro Ser Leu Leu Ile Glu Ser 
625                 630                 635                 640 


Asp Ser Pro Asp Lys Tyr Lys Lys Lys Lys Ser Ser Phe Lys Arg Phe 
                645                 650                 655     


Leu Ala Leu Thr Phe Lys Lys Lys Thr Glu Asn Lys Leu His Val Asp 
            660                 665                 670         


Val Asn Val Ser Ser Ser Arg Ser Ser Ser Glu Ser Ser Tyr His Gly 
        675                 680                 685             


Pro Ser Arg Ile Leu Glu Val Asp Arg Arg Ser Leu Ser Asn Ser Pro 
    690                 695                 700                 


Gln Leu Lys Ser Arg Thr Gly Lys Leu Arg Ala Ser Glu Ser Pro Ser 
705                 710                 715                 720 


Ser Leu Ile Phe Tyr Arg Asp Gly Lys Arg Lys Gly Val Pro Phe Ser 
                725                 730                 735     


Arg Thr Val Ser Arg Val Glu Ser Phe Glu Asp Arg Ser Arg Pro Pro 
            740                 745                 750         


Phe Leu Pro Leu Pro Leu Thr Lys Pro Arg Ser Ile Ser Phe Pro Ser 
        755                 760                 765             


Ala Asp Thr Ser Asp Tyr Glu Asn Ile Pro Ala Met Asn Ser Asp Tyr 
    770                 775                 780                 


Glu Asn Ile Gln Ile Pro Pro Arg Arg Pro Ala Arg Ala Gly Ala Phe 
785                 790                 795                 800 


Thr Lys Leu Phe Glu Asp Gln Ser Arg Ala Leu Ser Thr Ala Asn Glu 
                805                 810                 815     


Asn Asp Gly Tyr Val Asp Met Ser Ser Phe Asn Ala Phe Glu Ser Lys 
            820                 825                 830         


Gln Gln Ser Ala Asp Gln Asp Ala Glu Ser Ala Tyr Thr Glu Pro Tyr 
        835                 840                 845             


Lys Val Cys Pro Ile Ser Ser Ala Ala Pro Lys Glu Asp Leu Thr Ser 
    850                 855                 860                 


Asp Glu Glu Gln Arg Ser Ser Glu Glu Glu Asp Ser Ala Ser Arg Asp 
865                 870                 875                 880 


Pro Ser Val Thr His Lys Val Glu Gly Gln Ser Arg Ala Leu Val Ile 
                885                 890                 895     


Ala Gln Glu Leu Leu Ser Ser Glu Lys Ala Tyr Val Glu Met Leu Gln 
            900                 905                 910         


His Leu Asn Leu Asp Phe His Gly Ala Val Met Arg Ala Leu Asp Asp 
        915                 920                 925             


Met Asp His Glu Gly Arg Asp Thr Leu Ala Arg Glu Glu Leu Arg Gln 
    930                 935                 940                 


Gly Leu Ser Glu Leu Pro Ala Ile His Asp Leu His Gln Gly Ile Leu 
945                 950                 955                 960 


Glu Glu Leu Glu Glu Arg Leu Ser Asn Trp Glu Ser Gln Gln Lys Val 
                965                 970                 975     


Ala Asp Val Phe Leu Ala Arg Glu Gln Gly Phe Asp His His Ala Thr 
            980                 985                 990         


His Ile Leu Gln Phe Asp Arg Tyr  Leu Gly Leu Leu Ser  Glu Asn Cys 
        995                 1000                 1005             


Leu His  Ser Pro Arg Leu Ala  Ala Ala Val Arg Glu  Phe Glu Gln 
    1010                 1015                 1020             


Ser Val  Gln Gly Gly Ser Gln  Thr Ala Lys His Arg  Leu Leu Arg 
    1025                 1030                 1035             


Val Val  Gln Arg Leu Phe Gln  Tyr Gln Val Leu Leu  Thr Asp Tyr 
    1040                 1045                 1050             


Leu Asn  Asn Leu Cys Pro Asp  Ser Ala Glu Tyr Asp  Asn Thr Gln 
    1055                 1060                 1065             


Gly Ala  Leu Ser Leu Ile Ser  Lys Val Thr Asp Arg  Ala Asn Asp 
    1070                 1075                 1080             


Ser Met  Glu Gln Gly Glu Asn  Leu Gln Lys Leu Val  His Ile Glu 
    1085                 1090                 1095             


His Ser  Val Arg Gly Gln Gly  Asp Leu Leu Gln Pro  Gly Arg Glu 
    1100                 1105                 1110             


Phe Leu  Lys Glu Gly Thr Leu  Met Lys Val Thr Gly  Lys Asn Arg 
    1115                 1120                 1125             


Arg Pro  Arg His Leu Phe Leu  Met Asn Asp Val Leu  Leu Tyr Thr 
    1130                 1135                 1140             


Tyr Pro  Gln Lys Asp Gly Lys  Tyr Arg Leu Lys Asn  Thr Leu Ala 
    1145                 1150                 1155             


Val Ala  Asn Met Lys Val Ser  Arg Pro Val Met Glu  Lys Val Pro 
    1160                 1165                 1170             


Tyr Ala  Leu Lys Ile Glu Thr  Ser Glu Ser Cys Leu  Met Leu Ser 
    1175                 1180                 1185             


Ala Ser  Ser Cys Ala Glu Arg  Asp Glu Trp Tyr Gly  Cys Leu Ser 
    1190                 1195                 1200             


Arg Ala  Leu Pro Glu Asp Tyr  Lys Ala Gln Ala Leu  Ala Ala Phe 
    1205                 1210                 1215             


His His  Ser Val Glu Ile Arg  Glu Arg Leu Gly Val  Ser Leu Gly 
    1220                 1225                 1230             


Glu Arg  Pro Pro Thr Leu Val  Pro Val Thr His Val  Met Met Cys 
    1235                 1240                 1245             


Met Asn  Cys Gly Cys Asp Phe  Ser Leu Thr Leu Arg  Arg His His 
    1250                 1255                 1260             


Cys His  Ala Cys Gly Lys Ile  Val Cys Arg Asn Cys  Ser Arg Asn 
    1265                 1270                 1275             


Lys Tyr  Pro Leu Lys Tyr Leu  Lys Asp Arg Met Ala  Lys Val Cys 
    1280                 1285                 1290             


Asp Gly  Cys Phe Gly Glu Leu  Lys Lys Arg Gly Arg  Ala Val Pro 
    1295                 1300                 1305             


Gly Leu  Met Arg Glu Arg Pro  Val Ser Met Ser Phe  Pro Leu Ser 
    1310                 1315                 1320             


Ser Pro  Arg Phe Ser Gly Ser  Ala Phe Ser Ser Val  Phe Gln Ser 
    1325                 1330                 1335             


Ile Asn  Pro Ser Thr Phe Lys  Lys Gln Lys Lys Val  Pro Ser Ala 
    1340                 1345                 1350             


Leu Thr  Glu Val Ala Ala Ser  Gly Glu Gly Ser Ala  Ile Ser Gly 
    1355                 1360                 1365             


Tyr Leu  Ser Arg Cys Lys Arg  Gly Lys Arg His Trp  Lys Lys Leu 
    1370                 1375                 1380             


Trp Phe  Val Ile Lys Gly Lys  Val Leu Tyr Thr Tyr  Met Ala Ser 
    1385                 1390                 1395             


Glu Asp  Lys Val Ala Leu Glu  Ser Met Pro Leu Leu  Gly Phe Thr 
    1400                 1405                 1410             


Ile Ala  Pro Glu Lys Glu Glu  Gly Ser Ser Glu Val  Gly Pro Ile 
    1415                 1420                 1425             


Phe His  Leu Tyr His Lys Lys  Thr Leu Phe Tyr Ser  Phe Lys Ala 
    1430                 1435                 1440             


Glu Asp  Thr Asn Ser Ala Gln  Arg Trp Ile Glu Ala  Met Glu Asp 
    1445                 1450                 1455             


Ala Ser  Val Leu 
    1460         


<210>  4009
<211>  1430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGD6__Homo_sapiens__NP_060821

<400>  4009

Met Thr Ser Ala Ala Glu Ile Lys Lys Pro Pro Val Ala Pro Lys Pro 
1               5                   10                  15      


Lys Phe Val Val Ala Asn Asn Lys Pro Ala Pro Pro Pro Ile Ala Pro 
            20                  25                  30          


Lys Pro Asp Ile Val Ile Ser Ser Val Pro Gln Ser Thr Lys Lys Met 
        35                  40                  45              


Lys Pro Ala Ile Ala Pro Lys Pro Lys Val Leu Lys Thr Ser Pro Val 
    50                  55                  60                  


Arg Glu Ile Gly Gln Ser Pro Ser Arg Lys Ile Met Leu Asn Leu Glu 
65                  70                  75                  80  


Gly His Lys Gln Glu Leu Ala Glu Ser Thr Asp Asn Phe Asn Cys Lys 
                85                  90                  95      


Tyr Glu Gly Asn Gln Ser Asn Asp Tyr Ile Ser Pro Met Cys Ser Cys 
            100                 105                 110         


Ser Ser Glu Cys Ile His Lys Leu Gly His Arg Glu Asn Leu Cys Val 
        115                 120                 125             


Lys Gln Leu Val Leu Glu Pro Leu Glu Met Asn Glu Asn Leu Glu Asn 
    130                 135                 140                 


Ser Lys Ile Asp Glu Thr Leu Thr Ile Lys Thr Arg Ser Lys Cys Asp 
145                 150                 155                 160 


Leu Tyr Gly Glu Lys Ala Lys Asn Gln Gly Gly Val Val Leu Lys Ala 
                165                 170                 175     


Ser Val Leu Glu Glu Glu Leu Lys Asp Ala Leu Ile His Gln Met Pro 
            180                 185                 190         


Pro Phe Ile Ser Ala Gln Lys His Arg Pro Thr Asp Ser Pro Glu Met 
        195                 200                 205             


Asn Gly Gly Cys Asn Ser Asn Gly Gln Phe Arg Ile Glu Phe Ala Asp 
    210                 215                 220                 


Leu Ser Pro Ser Pro Ser Ser Phe Glu Lys Val Pro Asp His His Ser 
225                 230                 235                 240 


Cys His Leu Gln Leu Pro Ser Asp Glu Cys Glu His Phe Glu Thr Cys 
                245                 250                 255     


Gln Asp Asp Ser Glu Lys Ser Asn Asn Cys Phe Gln Ser Ser Glu Leu 
            260                 265                 270         


Glu Ala Leu Glu Asn Gly Lys Arg Ser Thr Leu Ile Ser Ser Asp Gly 
        275                 280                 285             


Val Ser Lys Lys Ser Glu Val Lys Asp Leu Gly Pro Leu Glu Ile His 
    290                 295                 300                 


Leu Val Pro Tyr Thr Pro Lys Phe Pro Thr Pro Lys Pro Arg Lys Thr 
305                 310                 315                 320 


Arg Thr Ala Arg Leu Leu Arg Gln Lys Cys Val Asp Thr Pro Ser Glu 
                325                 330                 335     


Ser Thr Glu Glu Pro Gly Asn Ser Asp Ser Ser Ser Ser Cys Leu Thr 
            340                 345                 350         


Glu Asn Ser Leu Lys Ile Asn Lys Ile Ser Val Leu His Gln Asn Val 
        355                 360                 365             


Leu Cys Lys Gln Glu Gln Val Asp Lys Met Lys Leu Gly Asn Lys Ser 
    370                 375                 380                 


Glu Leu Asn Met Glu Ser Asn Ser Asp Ala Gln Asp Leu Val Asn Ser 
385                 390                 395                 400 


Gln Lys Ala Met Cys Asn Glu Thr Thr Ser Phe Glu Lys Met Ala Pro 
                405                 410                 415     


Ser Phe Asp Lys Asp Ser Asn Leu Ser Ser Asp Ser Thr Thr Val Asp 
            420                 425                 430         


Gly Ser Ser Met Ser Leu Ala Val Asp Glu Gly Thr Gly Phe Ile Arg 
        435                 440                 445             


Cys Thr Val Ser Met Ser Leu Pro Lys Gln Leu Lys Leu Thr Cys Asn 
    450                 455                 460                 


Glu His Leu Gln Ser Gly Arg Asn Leu Gly Val Ser Ala Pro Gln Met 
465                 470                 475                 480 


Gln Lys Glu Ser Val Ile Lys Glu Glu Asn Ser Leu Arg Ile Val Pro 
                485                 490                 495     


Lys Lys Pro Gln Arg His Ser Leu Pro Ala Thr Gly Val Leu Lys Lys 
            500                 505                 510         


Ala Ala Ser Glu Glu Leu Leu Glu Lys Ser Ser Tyr Pro Ser Ser Glu 
        515                 520                 525             


Glu Lys Ser Ser Glu Lys Ser Leu Glu Arg Asn His Leu Gln His Leu 
    530                 535                 540                 


Cys Ala Gln Asn Arg Gly Val Ser Ser Ser Phe Asp Met Pro Lys Arg 
545                 550                 555                 560 


Ala Ser Glu Lys Pro Val Trp Lys Leu Pro His Pro Ile Leu Pro Phe 
                565                 570                 575     


Ser Gly Asn Pro Glu Phe Leu Lys Ser Val Thr Val Ser Ser Asn Ser 
            580                 585                 590         


Glu Pro Ser Thr Ala Leu Thr Lys Pro Arg Ala Lys Ser Leu Ser Ala 
        595                 600                 605             


Met Asp Val Glu Lys Cys Thr Lys Pro Cys Lys Asp Ser Thr Lys Lys 
    610                 615                 620                 


Asn Ser Phe Lys Lys Leu Leu Ser Met Lys Leu Ser Ile Cys Phe Met 
625                 630                 635                 640 


Lys Ser Asp Phe Gln Lys Phe Trp Ser Lys Ser Ser Gln Leu Gly Asp 
                645                 650                 655     


Thr Thr Thr Gly His Leu Ser Ser Gly Glu Gln Lys Gly Ile Glu Ser 
            660                 665                 670         


Asp Trp Gln Gly Leu Leu Val Gly Glu Glu Lys Arg Ser Lys Pro Ile 
        675                 680                 685             


Lys Ala Tyr Ser Thr Glu Asn Tyr Ser Leu Glu Ser Gln Lys Lys Arg 
    690                 695                 700                 


Lys Lys Ser Arg Gly Gln Thr Ser Ala Ala Asn Gly Leu Arg Ala Glu 
705                 710                 715                 720 


Ser Leu Asp Asp Gln Met Leu Ser Arg Glu Ser Ser Ser Gln Ala Pro 
                725                 730                 735     


Tyr Lys Ser Val Thr Ser Leu Cys Ala Pro Glu Tyr Glu Asn Ile Arg 
            740                 745                 750         


His Tyr Glu Glu Ile Pro Glu Tyr Glu Asn Leu Pro Phe Ile Met Ala 
        755                 760                 765             


Ile Arg Lys Thr Gln Glu Leu Glu Trp Gln Asn Ser Ser Ser Met Glu 
    770                 775                 780                 


Asp Ala Asp Ala Asn Val Tyr Glu Val Glu Glu Pro Tyr Glu Ala Pro 
785                 790                 795                 800 


Asp Gly Gln Leu Gln Leu Gly Pro Arg His Gln His Ser Ser Ser Gly 
                805                 810                 815     


Ala Ser Gln Glu Glu Gln Asn Asp Leu Gly Leu Gly Asp Leu Pro Ser 
            820                 825                 830         


Asp Glu Glu Glu Ile Ile Asn Ser Ser Asp Glu Asp Asp Val Ser Ser 
        835                 840                 845             


Glu Ser Ser Lys Gly Glu Pro Asp Pro Leu Glu Asp Lys Gln Asp Glu 
    850                 855                 860                 


Asp Asn Gly Met Lys Ser Lys Val His His Ile Ala Lys Glu Ile Met 
865                 870                 875                 880 


Ser Ser Glu Lys Val Phe Val Asp Val Leu Lys Leu Leu His Ile Asp 
                885                 890                 895     


Phe Arg Asp Ala Val Ala His Ala Ser Arg Gln Leu Gly Lys Pro Val 
            900                 905                 910         


Ile Glu Asp Arg Ile Leu Asn Gln Ile Leu Tyr Tyr Leu Pro Gln Leu 
        915                 920                 925             


Tyr Glu Leu Asn Arg Asp Leu Leu Lys Glu Leu Glu Glu Arg Met Leu 
    930                 935                 940                 


His Trp Thr Glu Gln Gln Arg Ile Ala Asp Ile Phe Val Lys Lys Gly 
945                 950                 955                 960 


Pro Tyr Leu Lys Met Tyr Ser Thr Tyr Ile Lys Glu Phe Asp Lys Asn 
                965                 970                 975     


Ile Ala Leu Leu Asp Glu Gln Cys Lys Lys Asn Pro Gly Phe Ala Ala 
            980                 985                 990         


Val Val Arg Glu Phe Glu Met Ser  Pro Arg Cys Ala Asn  Leu Ala Leu 
        995                 1000                 1005             


Lys His  Tyr Leu Leu Lys Pro  Val Gln Arg Ile Pro  Gln Tyr Arg 
    1010                 1015                 1020             


Leu Leu  Leu Thr Asp Tyr Leu  Lys Asn Leu Ile Glu  Asp Ala Gly 
    1025                 1030                 1035             


Asp Tyr  Arg Asp Thr Gln Asp  Ala Leu Ala Val Val  Ile Glu Val 
    1040                 1045                 1050             


Ala Asn  His Ala Asn Asp Thr  Met Lys Gln Gly Asp  Asn Phe Gln 
    1055                 1060                 1065             


Lys Leu  Met Gln Ile Gln Tyr  Ser Leu Asn Gly His  His Glu Ile 
    1070                 1075                 1080             


Val Gln  Pro Gly Arg Val Phe  Leu Lys Glu Gly Ile  Leu Met Lys 
    1085                 1090                 1095             


Leu Ser  Arg Lys Val Met Gln  Pro Arg Met Phe Phe  Leu Phe Asn 
    1100                 1105                 1110             


Asp Ala  Leu Leu Tyr Thr Thr  Pro Val Gln Ser Gly  Met Tyr Lys 
    1115                 1120                 1125             


Leu Asn  Asn Met Leu Ser Leu  Ala Gly Met Lys Val  Arg Lys Pro 
    1130                 1135                 1140             


Thr Gln  Glu Ala Tyr Gln Asn  Glu Leu Lys Ile Glu  Ser Val Glu 
    1145                 1150                 1155             


Arg Ser  Phe Ile Leu Ser Ala  Ser Ser Ala Thr Glu  Arg Asp Glu 
    1160                 1165                 1170             


Trp Leu  Glu Ala Ile Ser Arg  Ala Ile Glu Glu Tyr  Ala Lys Lys 
    1175                 1180                 1185             


Arg Ile  Thr Phe Cys Pro Ser  Arg Ser Leu Asp Glu  Ala Asp Ser 
    1190                 1195                 1200             


Glu Asn  Lys Glu Glu Val Ser  Pro Leu Gly Ser Lys  Ala Pro Ile 
    1205                 1210                 1215             


Trp Ile  Pro Asp Thr Arg Ala  Thr Met Cys Met Ile  Cys Thr Ser 
    1220                 1225                 1230             


Glu Phe  Thr Leu Thr Trp Arg  Arg His His Cys Arg  Ala Cys Gly 
    1235                 1240                 1245             


Lys Ile  Val Cys Gln Ala Cys  Ser Ser Asn Lys Tyr  Gly Leu Asp 
    1250                 1255                 1260             


Tyr Leu  Lys Asn Gln Pro Ala  Arg Val Cys Glu His  Cys Phe Gln 
    1265                 1270                 1275             


Glu Leu  Gln Lys Leu Asp His  Gln His Ser Pro Arg  Ile Gly Ser 
    1280                 1285                 1290             


Pro Gly  Asn His Lys Ser Pro  Ser Ser Ala Leu Ser  Ser Val Leu 
    1295                 1300                 1305             


His Ser  Ile Pro Ser Gly Arg  Lys Gln Lys Lys Ile  Pro Ala Ala 
    1310                 1315                 1320             


Leu Lys  Glu Val Ser Ala Asn  Thr Glu Asp Ser Ser  Met Ser Gly 
    1325                 1330                 1335             


Tyr Leu  Tyr Arg Ser Lys Gly  Asn Lys Lys Pro Trp  Lys His Phe 
    1340                 1345                 1350             


Trp Phe  Val Ile Lys Asn Lys  Val Leu Tyr Thr Tyr  Ala Ala Ser 
    1355                 1360                 1365             


Glu Asp  Val Ala Ala Leu Glu  Ser Gln Pro Leu Leu  Gly Phe Thr 
    1370                 1375                 1380             


Val Ile  Gln Val Lys Asp Glu  Asn Ser Glu Ser Lys  Val Phe Gln 
    1385                 1390                 1395             


Leu Leu  His Lys Asn Met Leu  Phe Tyr Val Phe Lys  Ala Glu Asp 
    1400                 1405                 1410             


Ala His  Ser Ala Gln Lys Trp  Ile Glu Ala Phe Gln  Glu Gly Thr 
    1415                 1420                 1425             


Ile Leu  
    1430 


<210>  4010
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF10__Homo_sapiens__XP_005248321

<400>  4010

Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg 
65                  70                  75                  80  


Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu 
            100                 105                 110         


Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser 
        115                 120                 125             


Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys 
    130                 135                 140                 


Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly 
145                 150                 155                 160 


Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met 
                165                 170                 175     


Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr 
            180                 185                 190         


Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Val Val His Ser 
        195                 200                 205             


<210>  4011
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF11__Homo_sapiens__NP_004103

<400>  4011

Met Ala Ala Leu Ala Ser Ser Leu Ile Arg Gln Lys Arg Glu Val Arg 
1               5                   10                  15      


Glu Pro Gly Gly Ser Arg Pro Val Ser Ala Gln Arg Arg Val Cys Pro 
            20                  25                  30          


Arg Gly Thr Lys Ser Leu Cys Gln Lys Gln Leu Leu Ile Leu Leu Ser 
        35                  40                  45              


Lys Val Arg Leu Cys Gly Gly Arg Pro Ala Arg Pro Asp Arg Gly Pro 
    50                  55                  60                  


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Phe Cys Arg Gln Gly 
65                  70                  75                  80  


Phe Tyr Leu Gln Ala Asn Pro Asp Gly Ser Ile Gln Gly Thr Pro Glu 
                85                  90                  95      


Asp Thr Ser Ser Phe Thr His Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Thr Ile Gln Ser Ala Lys Leu Gly His Tyr Met Ala Met Asn 
        115                 120                 125             


Ala Glu Gly Leu Leu Tyr Ser Ser Pro His Phe Thr Ala Glu Cys Arg 
    130                 135                 140                 


Phe Lys Glu Cys Val Phe Glu Asn Tyr Tyr Val Leu Tyr Ala Ser Ala 
145                 150                 155                 160 


Leu Tyr Arg Gln Arg Arg Ser Gly Arg Ala Trp Tyr Leu Gly Leu Asp 
                165                 170                 175     


Lys Glu Gly Gln Val Met Lys Gly Asn Arg Val Lys Lys Thr Lys Ala 
            180                 185                 190         


Ala Ala His Phe Leu Pro Lys Leu Leu Glu Val Ala Met Tyr Gln Glu 
        195                 200                 205             


Pro Ser Leu His Ser Val Pro Glu Ala Ser Pro Ser Ser Pro Pro Ala 
    210                 215                 220                 


Pro 
225 


<210>  4012
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF12__Homo_sapiens__NP_004104

<400>  4012

Met Glu Ser Lys Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe 
1               5                   10                  15      


Ser Gln Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp 
            20                  25                  30          


Gly Thr Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro 
        35                  40                  45              


Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr 
    50                  55                  60                  


Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr 
65                  70                  75                  80  


Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile 
                85                  90                  95      


Tyr Ser Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe 
            100                 105                 110         


Leu Gly Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys 
        115                 120                 125             


Lys Thr Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys 
    130                 135                 140                 


Met Tyr Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg 
145                 150                 155                 160 


Ser Arg Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val 
                165                 170                 175     


Asn Gln Asp Ser Thr 
            180     


<210>  4013
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF13__Homo_sapiens__NP_001132970

<400>  4013

Met Ser Gly Lys Val Thr Lys Pro Lys Glu Glu Lys Asp Ala Ser Lys 
1               5                   10                  15      


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly 
            20                  25                  30          


Tyr His Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp 
        35                  40                  45              


Glu Asp Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg 
    50                  55                  60                  


Val Val Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn 
65                  70                  75                  80  


Ser Glu Gly Tyr Leu Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys 
                85                  90                  95      


Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met 
            100                 105                 110         


Ile Tyr Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn 
        115                 120                 125             


Lys Glu Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro 
    130                 135                 140                 


Ala Ala His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu 
145                 150                 155                 160 


Pro Ser Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr 
                165                 170                 175     


Pro Thr Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser 
            180                 185                 190         


Met Ser His Asn Glu Ser Thr 
        195                 


<210>  4014
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF14__Homo_sapiens__NP_004106

<400>  4014

Met Ala Ala Ala Ile Ala Ser Gly Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Gln His Trp Asp Arg Pro Ser Ala Ser Arg Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Lys Asn Arg Gly Leu Cys Asn Gly Asn Leu Val Asp Ile Phe 
        35                  40                  45              


Ser Lys Val Arg Ile Phe Gly Leu Lys Lys Arg Arg Leu Arg Arg Gln 
    50                  55                  60                  


Asp Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Tyr Cys Arg Gln Gly 
65                  70                  75                  80  


Tyr Tyr Leu Gln Met His Pro Asp Gly Ala Leu Asp Gly Thr Lys Asp 
                85                  90                  95      


Asp Ser Thr Asn Ser Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Ala Ile Gln Gly Val Lys Thr Gly Leu Tyr Ile Ala Met Asn 
        115                 120                 125             


Gly Glu Gly Tyr Leu Tyr Pro Ser Glu Leu Phe Thr Pro Glu Cys Lys 
    130                 135                 140                 


Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser Ser Met 
145                 150                 155                 160 


Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly Leu Asn 
                165                 170                 175     


Lys Glu Gly Gln Ala Met Lys Gly Asn Arg Val Lys Lys Thr Lys Pro 
            180                 185                 190         


Ala Ala His Phe Leu Pro Lys Pro Leu Glu Val Ala Met Tyr Arg Glu 
        195                 200                 205             


Pro Ser Leu His Asp Val Gly Glu Thr Val Pro Lys Pro Gly Val Thr 
    210                 215                 220                 


Pro Ser Lys Ser Thr Ser Ala Ser Ala Ile Met Asn Gly Gly Lys Pro 
225                 230                 235                 240 


Val Asn Lys Ser Lys Thr Thr 
                245         


<210>  4015
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF16__Homo_sapiens__NP_003859

<400>  4015

Met Ala Glu Val Gly Gly Val Phe Ala Ser Leu Asp Trp Asp Leu His 
1               5                   10                  15      


Gly Phe Ser Ser Ser Leu Gly Asn Val Pro Leu Ala Asp Ser Pro Gly 
            20                  25                  30          


Phe Leu Asn Glu Arg Leu Gly Gln Ile Glu Gly Lys Leu Gln Arg Gly 
        35                  40                  45              


Ser Pro Thr Asp Phe Ala His Leu Lys Gly Ile Leu Arg Arg Arg Gln 
    50                  55                  60                  


Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly Thr 
65                  70                  75                  80  


Val His Gly Thr Arg His Asp His Ser Arg Phe Gly Ile Leu Glu Phe 
                85                  90                  95      


Ile Ser Leu Ala Val Gly Leu Ile Ser Ile Arg Gly Val Asp Ser Gly 
            100                 105                 110         


Leu Tyr Leu Gly Met Asn Glu Arg Gly Glu Leu Tyr Gly Ser Lys Lys 
        115                 120                 125             


Leu Thr Arg Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp Tyr 
    130                 135                 140                 


Asn Thr Tyr Ala Ser Thr Leu Tyr Lys His Ser Asp Ser Glu Arg Gln 
145                 150                 155                 160 


Tyr Tyr Val Ala Leu Asn Lys Asp Gly Ser Pro Arg Glu Gly Tyr Arg 
                165                 170                 175     


Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val Asp 
            180                 185                 190         


Pro Ser Lys Leu Pro Ser Met Ser Arg Asp Leu Phe His Tyr Arg 
        195                 200                 205         


<210>  4016
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF17__Homo_sapiens__NP_001291407

<400>  4016

Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      


Leu Ile Leu Cys Cys Gln Thr Gln Tyr Val Arg Asp Gln Gly Ala Met 
            20                  25                  30          


Thr Asp Gln Leu Ser Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser 
        35                  40                  45              


Arg Thr Ser Gly Lys His Val Gln Val Thr Gly Arg Arg Ile Ser Ala 
    50                  55                  60                  


Thr Ala Glu Asp Gly Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  


Thr Phe Gly Ser Arg Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr 
                85                  90                  95      


Ile Cys Met Asn Lys Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys 
            100                 105                 110         


Ser Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             


Ala Phe Gln Asn Ala Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg 
    130                 135                 140                 


Gln Gly Arg Pro Arg Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu 
145                 150                 155                 160 


Ala His Phe Ile Lys Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn 
                165                 170                 175     


His Ala Glu Lys Gln Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr 
            180                 185                 190         


Arg Arg Thr Lys Arg Thr Arg Arg Pro Gln Pro Leu Thr 
        195                 200                 205 


<210>  4017
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF18__Homo_sapiens__NP_003853

<400>  4017

Met Tyr Ser Ala Pro Ser Ala Cys Thr Cys Leu Cys Leu His Phe Leu 
1               5                   10                  15      


Leu Leu Cys Phe Gln Val Gln Val Leu Val Ala Glu Glu Asn Val Asp 
            20                  25                  30          


Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala Arg Asp Asp Val Ser 
        35                  40                  45              


Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala Arg Gly Glu Asp Gly 
65                  70                  75                  80  


Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp Thr Phe Gly Ser Gln 
                85                  90                  95      


Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr Leu Cys Met Asn Arg 
            100                 105                 110         


Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr Ser Lys Glu Cys Val 
        115                 120                 125             


Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr Ala Leu Met Ser Ala 
    130                 135                 140                 


Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp Val His Phe Met Lys 
                165                 170                 175     


Arg Tyr Pro Lys Gly Gln Pro Glu Leu Gln Lys Pro Phe Lys Tyr Thr 
            180                 185                 190         


Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro Thr His Pro Ala 
        195                 200                 205         


<210>  4018
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF19__Homo_sapiens__NP_005108

<400>  4018

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  4019
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF1__Homo_sapiens__NP_001244139

<400>  4019

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  4020
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF20__Homo_sapiens__NP_062825

<400>  4020

Met Ala Pro Leu Ala Glu Val Gly Gly Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Ser Ala Ala Glu Arg Ser Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ala Ala Gln Leu Ala His Leu His Gly Ile Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Ser Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Asp Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asp 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg His Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Met Tyr Thr 
    210     


<210>  4021
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF21__Homo_sapiens__XP_005258788

<400>  4021

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  4022
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF23__Homo_sapiens__NP_065689

<400>  4022

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  4023
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF2__Homo_sapiens__NP_001997

<400>  4023

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  4024
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF3__Homo_sapiens__NP_005238

<400>  4024

Met Gly Leu Ile Trp Leu Leu Leu Leu Ser Leu Leu Glu Pro Gly Trp 
1               5                   10                  15      


Pro Ala Ala Gly Pro Gly Ala Arg Leu Arg Arg Asp Ala Gly Gly Arg 
            20                  25                  30          


Gly Gly Val Tyr Glu His Leu Gly Gly Ala Pro Arg Arg Arg Lys Leu 
        35                  40                  45              


Tyr Cys Ala Thr Lys Tyr His Leu Gln Leu His Pro Ser Gly Arg Val 
    50                  55                  60                  


Asn Gly Ser Leu Glu Asn Ser Ala Tyr Ser Ile Leu Glu Ile Thr Ala 
65                  70                  75                  80  


Val Glu Val Gly Ile Val Ala Ile Arg Gly Leu Phe Ser Gly Arg Tyr 
                85                  90                  95      


Leu Ala Met Asn Lys Arg Gly Arg Leu Tyr Ala Ser Glu His Tyr Ser 
            100                 105                 110         


Ala Glu Cys Glu Phe Val Glu Arg Ile His Glu Leu Gly Tyr Asn Thr 
        115                 120                 125             


Tyr Ala Ser Arg Leu Tyr Arg Thr Val Ser Ser Thr Pro Gly Ala Arg 
    130                 135                 140                 


Arg Gln Pro Ser Ala Glu Arg Leu Trp Tyr Val Ser Val Asn Gly Lys 
145                 150                 155                 160 


Gly Arg Pro Arg Arg Gly Phe Lys Thr Arg Arg Thr Gln Lys Ser Ser 
                165                 170                 175     


Leu Phe Leu Pro Arg Val Leu Asp His Arg Asp His Glu Met Val Arg 
            180                 185                 190         


Gln Leu Gln Ser Gly Leu Pro Arg Pro Pro Gly Lys Gly Val Gln Pro 
        195                 200                 205             


Arg Arg Arg Arg Gln Lys Gln Ser Pro Asp Asn Leu Glu Pro Ser His 
    210                 215                 220                 


Val Gln Ala Ser Arg Leu Gly Ser Gln Leu Glu Ala Ser Ala His 
225                 230                 235                 


<210>  4025
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF4__Homo_sapiens__XP_006718538

<400>  4025

Met Ser Gly Pro Gly Thr Ala Ala Val Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Leu Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Ala Leu Pro Asp Gly Arg Ile Gly Gly Ala His Ala Asp Thr Arg 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Thr Phe Lys Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Tyr Lys Tyr Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Thr Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210>  4026
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF5__Homo_sapiens__NP_004455

<400>  4026

Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro 
            20                  25                  30          


Gly Pro Ala Ala Thr Asp Arg Asn Pro Arg Gly Ser Ser Ser Arg Gln 
        35                  40                  45              


Ser Ser Ser Ser Ala Met Ser Ser Ser Ser Ala Ser Ser Ser Pro Ala 
    50                  55                  60                  


Ala Ser Leu Gly Ser Gln Gly Ser Gly Leu Glu Gln Ser Ser Phe Gln 
65                  70                  75                  80  


Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly 
                85                  90                  95      


Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser 
            100                 105                 110         


His Glu Ala Asn Met Leu Ser Val Leu Glu Ile Phe Ala Val Ser Gln 
        115                 120                 125             


Gly Ile Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met 
    130                 135                 140                 


Ser Lys Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys 
145                 150                 155                 160 


Lys Phe Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser 
                165                 170                 175     


Ala Ile His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu 
            180                 185                 190         


Asn Lys Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro 
        195                 200                 205             


Gln His Ile Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln 
    210                 215                 220                 


Pro Glu Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro 
225                 230                 235                 240 


Ser Pro Ile Lys Pro Lys Ile Pro Leu Ser Ala Pro Arg Lys Asn Thr 
                245                 250                 255     


Asn Ser Val Lys Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 265             


<210>  4027
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF6__Homo_sapiens__NP_066276

<400>  4027

Met Ala Leu Gly Gln Lys Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Leu Gln Gly Thr Leu Trp Ala Leu Val Phe Leu Gly Ile Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Leu Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Arg Ser Ala Leu Phe Val Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Gln Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210>  4028
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF7__Homo_sapiens__NP_002000

<400>  4028

Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210>  4029
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF8__Homo_sapiens__NP_006110

<400>  4029

Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Val Thr Val Gln Ser Ser Pro Asn Phe 
            20                  25                  30          


Thr Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg 
        35                  40                  45              


Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  


Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  


Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      


Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         


Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val 
        115                 120                 125             


Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala 
    130                 135                 140                 


Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     


Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu 
            180                 185                 190         


Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg 
        195                 200                 205             


Thr Trp Ala Pro Glu Pro Arg 
    210                 215 


<210>  4030
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF9__Homo_sapiens__NP_002001

<400>  4030

Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210>  4031
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFBP1__Homo_sapiens__NP_005121

<400>  4031

Met Lys Ile Cys Ser Leu Thr Leu Leu Ser Phe Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Val Leu Leu Val Glu Gly Lys Lys Lys Val Lys Asn Gly Leu His 
            20                  25                  30          


Ser Lys Val Val Ser Glu Gln Lys Asp Thr Leu Gly Asn Thr Gln Ile 
        35                  40                  45              


Lys Gln Lys Ser Arg Pro Gly Asn Lys Gly Lys Phe Val Thr Lys Asp 
    50                  55                  60                  


Gln Ala Asn Cys Arg Trp Ala Ala Thr Glu Gln Glu Glu Gly Ile Ser 
65                  70                  75                  80  


Leu Lys Val Glu Cys Thr Gln Leu Asp His Glu Phe Ser Cys Val Phe 
                85                  90                  95      


Ala Gly Asn Pro Thr Ser Cys Leu Lys Leu Lys Asp Glu Arg Val Tyr 
            100                 105                 110         


Trp Lys Gln Val Ala Arg Asn Leu Arg Ser Gln Lys Asp Ile Cys Arg 
        115                 120                 125             


Tyr Ser Lys Thr Ala Val Lys Thr Arg Val Cys Arg Lys Asp Phe Pro 
    130                 135                 140                 


Glu Ser Ser Leu Lys Leu Val Ser Ser Thr Leu Phe Gly Asn Thr Lys 
145                 150                 155                 160 


Pro Arg Lys Glu Lys Thr Glu Met Ser Pro Arg Glu His Ile Lys Gly 
                165                 170                 175     


Lys Glu Thr Thr Pro Ser Ser Leu Ala Val Thr Gln Thr Met Ala Thr 
            180                 185                 190         


Lys Ala Pro Glu Cys Val Glu Asp Pro Asp Met Ala Asn Gln Arg Lys 
        195                 200                 205             


Thr Ala Leu Glu Phe Cys Gly Glu Thr Trp Ser Ser Leu Cys Thr Phe 
    210                 215                 220                 


Phe Leu Ser Ile Val Gln Asp Thr Ser Cys 
225                 230                 


<210>  4032
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFBP2__Homo_sapiens__NP_114156

<400>  4032

Met Lys Phe Val Pro Cys Leu Leu Leu Val Thr Leu Ser Cys Leu Gly 
1               5                   10                  15      


Thr Leu Gly Gln Ala Pro Arg Gln Lys Gln Gly Ser Thr Gly Glu Glu 
            20                  25                  30          


Phe His Phe Gln Thr Gly Gly Arg Asp Ser Cys Thr Met Arg Pro Ser 
        35                  40                  45              


Ser Leu Gly Gln Gly Ala Gly Glu Val Trp Leu Arg Val Asp Cys Arg 
    50                  55                  60                  


Asn Thr Asp Gln Thr Tyr Trp Cys Glu Tyr Arg Gly Gln Pro Ser Met 
65                  70                  75                  80  


Cys Gln Ala Phe Ala Ala Asp Pro Lys Pro Tyr Trp Asn Gln Ala Leu 
                85                  90                  95      


Gln Glu Leu Arg Arg Leu His His Ala Cys Gln Gly Ala Pro Val Leu 
            100                 105                 110         


Arg Pro Ser Val Cys Arg Glu Ala Gly Pro Gln Ala His Met Gln Gln 
        115                 120                 125             


Val Thr Ser Ser Leu Lys Gly Ser Pro Glu Pro Asn Gln Gln Pro Glu 
    130                 135                 140                 


Ala Gly Thr Pro Ser Leu Arg Pro Lys Ala Thr Val Lys Leu Thr Glu 
145                 150                 155                 160 


Ala Thr Gln Leu Gly Lys Asp Ser Met Glu Glu Leu Gly Lys Ala Lys 
                165                 170                 175     


Pro Thr Thr Arg Pro Thr Ala Lys Pro Thr Gln Pro Gly Pro Arg Pro 
            180                 185                 190         


Gly Gly Asn Glu Glu Ala Lys Lys Lys Ala Trp Glu His Cys Trp Lys 
        195                 200                 205             


Pro Phe Gln Ala Leu Cys Ala Phe Leu Ile Ser Phe Phe Arg Gly 
    210                 215                 220             


<210>  4033
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFBP3__Homo_sapiens__NP_689642

<400>  4033

Met Thr Pro Pro Lys Leu Arg Ala Ser Leu Ser Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Gly Cys Leu Leu Ala Ala Ala Arg Arg Glu Lys Gly Ala 
            20                  25                  30          


Ala Ser Asn Val Ala Glu Pro Val Pro Gly Pro Thr Gly Gly Ser Ser 
        35                  40                  45              


Gly Arg Phe Leu Ser Pro Glu Gln His Ala Cys Ser Trp Gln Leu Leu 
    50                  55                  60                  


Leu Pro Ala Pro Glu Ala Ala Ala Gly Ser Glu Leu Ala Leu Arg Cys 
65                  70                  75                  80  


Gln Ser Pro Asp Gly Ala Arg His Gln Cys Ala Tyr Arg Gly His Pro 
                85                  90                  95      


Glu Arg Cys Ala Ala Tyr Ala Ala Arg Arg Ala His Phe Trp Lys Gln 
            100                 105                 110         


Val Leu Gly Gly Leu Arg Lys Lys Arg Arg Pro Cys His Asp Pro Ala 
        115                 120                 125             


Pro Leu Gln Ala Arg Leu Cys Ala Gly Lys Lys Gly His Gly Ala Glu 
    130                 135                 140                 


Leu Arg Leu Val Pro Arg Ala Ser Pro Pro Ala Arg Pro Thr Val Ala 
145                 150                 155                 160 


Gly Phe Ala Gly Glu Ser Lys Pro Arg Ala Arg Asn Arg Gly Arg Thr 
                165                 170                 175     


Arg Glu Arg Ala Ser Gly Pro Ala Ala Gly Thr Pro Pro Pro Gln Ser 
            180                 185                 190         


Ala Pro Pro Lys Glu Asn Pro Ser Glu Arg Lys Thr Asn Glu Gly Lys 
        195                 200                 205             


Arg Lys Ala Ala Leu Val Pro Asn Glu Glu Arg Pro Met Gly Thr Gly 
    210                 215                 220                 


Pro Asp Pro Asp Gly Leu Asp Gly Asn Ala Glu Leu Thr Glu Thr Tyr 
225                 230                 235                 240 


Cys Ala Glu Lys Trp His Ser Leu Cys Asn Phe Phe Val Asn Phe Trp 
                245                 250                 255     


Asn Gly 
        


<210>  4034
<211>  812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR1__Homo_sapiens__NP_001167535

<400>  4034

Met Ala Ala Val Thr Arg Asp Phe Gly Glu Met Leu Leu His Ser Gly 
1               5                   10                  15      


Arg Val Leu Pro Ala Glu Ala Gln Pro Trp Gly Ala Pro Val Glu Val 
            20                  25                  30          


Glu Ser Phe Leu Val His Pro Gly Asp Leu Leu Gln Leu Arg Cys Arg 
        35                  40                  45              


Leu Arg Asp Asp Val Gln Ser Ile Asn Trp Leu Arg Asp Gly Val Gln 
    50                  55                  60                  


Leu Ala Glu Ser Asn Arg Thr Arg Ile Thr Gly Glu Glu Val Glu Val 
65                  70                  75                  80  


Gln Asp Ser Val Pro Ala Asp Ser Gly Leu Tyr Ala Cys Val Thr Ser 
                85                  90                  95      


Ser Pro Ser Gly Ser Asp Thr Thr Tyr Phe Ser Val Asn Val Ser Asp 
            100                 105                 110         


Ala Leu Pro Ser Ser Glu Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser 
        115                 120                 125             


Glu Glu Lys Glu Thr Asp Asn Thr Lys Pro Asn Arg Met Pro Val Ala 
    130                 135                 140                 


Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu Lys Lys Leu His Ala Val 
145                 150                 155                 160 


Pro Ala Ala Lys Thr Val Lys Phe Lys Cys Pro Ser Ser Gly Thr Pro 
                165                 170                 175     


Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Pro Asp 
            180                 185                 190         


His Arg Ile Gly Gly Tyr Lys Val Arg Tyr Ala Thr Trp Ser Ile Ile 
        195                 200                 205             


Met Asp Ser Val Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Ile Val 
    210                 215                 220                 


Glu Asn Glu Tyr Gly Ser Ile Asn His Thr Tyr Gln Leu Asp Val Val 
225                 230                 235                 240 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                245                 250                 255     


Lys Thr Val Ala Leu Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr 
            260                 265                 270         


Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn 
        275                 280                 285             


Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys 
    290                 295                 300                 


Thr Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu 
305                 310                 315                 320 


Arg Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu 
            340                 345                 350         


Ala Leu Glu Glu Arg Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu 
        355                 360                 365             


Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu Ile Ser Cys Met Val Gly 
    370                 375                 380                 


Ser Val Ile Val Tyr Lys Met Lys Ser Gly Thr Lys Lys Ser Asp Phe 
385                 390                 395                 400 


His Ser Gln Met Ala Val His Lys Leu Ala Lys Ser Ile Pro Leu Arg 
                405                 410                 415     


Arg Gln Val Ser Ala Asp Ser Ser Ala Ser Met Asn Ser Gly Val Leu 
            420                 425                 430         


Leu Val Arg Pro Ser Arg Leu Ser Ser Ser Gly Thr Pro Met Leu Ala 
        435                 440                 445             


Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro 
    450                 455                 460                 


Arg Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly 
465                 470                 475                 480 


Gln Val Val Leu Ala Glu Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn 
                485                 490                 495     


Arg Val Thr Lys Val Ala Val Lys Met Leu Lys Ser Asp Ala Thr Glu 
            500                 505                 510         


Lys Asp Leu Ser Asp Leu Ile Ser Glu Met Glu Met Met Lys Met Ile 
        515                 520                 525             


Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp 
    530                 535                 540                 


Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg 
545                 550                 555                 560 


Glu Tyr Leu Gln Ala Arg Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn 
                565                 570                 575     


Pro Ser His Asn Pro Glu Glu Gln Leu Ser Ser Lys Asp Leu Val Ser 
            580                 585                 590         


Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys 
        595                 600                 605             


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp 
    610                 615                 620                 


Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile His His 
625                 630                 635                 640 


Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp 
                645                 650                 655     


Met Ala Pro Glu Ala Leu Phe Asp Arg Ile Tyr Thr His Gln Ser Asp 
            660                 665                 670         


Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly 
        675                 680                 685             


Ser Pro Tyr Pro Gly Val Pro Val Glu Glu Leu Phe Lys Leu Leu Lys 
    690                 695                 700                 


Glu Gly His Arg Met Asp Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr 
705                 710                 715                 720 


Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr 
                725                 730                 735     


Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Val Ala Leu Thr Ser 
            740                 745                 750         


Asn Gln Glu Tyr Leu Asp Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro 
        755                 760                 765             


Ser Phe Pro Asp Thr Arg Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser 
    770                 775                 780                 


Val Phe Ser His Glu Pro Leu Pro Glu Glu Pro Cys Leu Pro Arg His 
785                 790                 795                 800 


Pro Ala Gln Leu Ala Asn Gly Gly Leu Lys Arg Arg 
                805                 810         


<210>  4035
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR1OP2__Homo_sapiens__NP_001165358

<400>  4035

Met Ser Cys Thr Ile Glu Lys Ala Leu Ala Asp Ala Lys Ala Leu Val 
1               5                   10                  15      


Glu Arg Leu Arg Asp His Asp Asp Ala Ala Glu Ser Leu Ile Glu Gln 
            20                  25                  30          


Thr Thr Ala Leu Asn Lys Arg Val Glu Ala Met Lys Gln Tyr Gln Glu 
        35                  40                  45              


Glu Ile Gln Glu Leu Asn Glu Val Ala Arg His Arg Pro Arg Ser Thr 
    50                  55                  60                  


Leu Val Met Gly Ile Gln Gln Glu Asn Arg Gln Ile Arg Glu Leu Gln 
65                  70                  75                  80  


Gln Glu Asn Lys Glu Leu Arg Thr Ser Leu Glu Glu His Gln Ser Ala 
                85                  90                  95      


Leu Glu Leu Ile Met Ser Lys Tyr Arg Glu Gln Met Phe Arg Leu Leu 
            100                 105                 110         


Met Ala Ser Lys Lys Asp Asp Pro Gly Ile Ile Met Lys Leu Lys Glu 
        115                 120                 125             


Gln His Ser Lys Glu Leu Gln Ala His Val Asp Gln Ile Thr Glu Met 
    130                 135                 140                 


Ala Ala Val Met Arg Lys Ala Ile Glu Ile Asp Glu Gln Gln Gly Cys 
145                 150                 155                 160 


Lys Glu Gln Glu Arg Ile Phe Gln Leu Glu Gln Glu Asn Lys Gly Leu 
                165                 170                 175     


Arg Glu Ile Leu Gln Ile Thr Arg Glu Ser Phe Leu Asn Leu Arg Lys 
            180                 185                 190         


Asp Asp Ala Ser Glu Ser Thr Ser Leu Ser Ala Leu Val Thr Asn Ser 
        195                 200                 205             


Asp Leu Ser Leu Arg Lys Ser 
    210                 215 


<210>  4036
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR1OP__Homo_sapiens__NP_001265619

<400>  4036

Met Ala Ala Thr Ala Ala Ala Val Val Ala Glu Glu Asp Thr Glu Leu 
1               5                   10                  15      


Arg Asp Leu Leu Val Gln Thr Leu Glu Asn Ser Gly Val Leu Asn Arg 
            20                  25                  30          


Ile Lys Ala Glu Leu Arg Ala Ala Val Phe Leu Ala Leu Glu Glu Gln 
        35                  40                  45              


Glu Lys Val Glu Asn Lys Thr Pro Leu Val Asn Glu Ser Leu Lys Lys 
    50                  55                  60                  


Phe Leu Asn Thr Lys Asp Gly Arg Leu Val Ala Ser Leu Val Ala Glu 
65                  70                  75                  80  


Phe Leu Gln Phe Phe Asn Leu Asp Phe Thr Leu Ala Val Phe Gln Pro 
                85                  90                  95      


Glu Thr Ser Thr Leu Gln Gly Leu Glu Gly Arg Glu Asn Leu Ala Arg 
            100                 105                 110         


Asp Leu Gly Ile Ile Glu Ala Glu Gly Thr Val Gly Gly Pro Leu Leu 
        115                 120                 125             


Leu Glu Val Ile Arg Arg Cys Gln Gln Lys Glu Lys Gly Pro Thr Thr 
    130                 135                 140                 


Gly Glu Lys Ala Asn Asp Glu Ala Asn Gln Ser Asp Thr Ser Val Ser 
145                 150                 155                 160 


Leu Ser Glu Pro Lys Ser Lys Ser Ser Leu His Leu Leu Ser His Glu 
                165                 170                 175     


Thr Lys Ile Gly Ser Phe Leu Ser Asn Arg Thr Leu Asp Gly Lys Asp 
            180                 185                 190         


Lys Ala Gly Leu Cys Pro Asp Glu Asp Asp Met Glu Gly Asp Ser Phe 
        195                 200                 205             


Phe Asp Asp Pro Ile Pro Lys Pro Glu Lys Thr Tyr Gly Leu Arg Lys 
    210                 215                 220                 


Glu Pro Arg Lys Gln Ala Gly Ser Leu Ala Ser Leu Ser Asp Ala Pro 
225                 230                 235                 240 


Pro Leu Lys Ser Gly Leu Ser Ser Leu Ala Gly Ala Pro Ser Leu Lys 
                245                 250                 255     


Asp Ser Glu Ser Lys Arg Gly Asn Thr Val Leu Lys Asp Leu Lys Leu 
            260                 265                 270         


Ile Ser Asp Lys Ile Gly Ser Leu Gly Leu Gly Thr Gly Glu Asp Asp 
        275                 280                 285             


Asp Tyr Val Asp Asp Phe Asn Ser Thr Ser His Arg Ser Glu Lys Ser 
    290                 295                 300                 


Glu Ile Ser Ile Gly Glu Glu Ile Glu Glu Asp Leu Ser Val Glu Ile 
305                 310                 315                 320 


Asp Asp Ile Asn Thr Ser Asp Lys Thr Ile Thr Gln Leu Glu Cys Leu 
                325                 330                 335     


Leu Ser Ile Gly Ala Leu His Phe Lys Asn Thr Ala Asp Ile Phe 
            340                 345                 350     


<210>  4037
<211>  821
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR2__Homo_sapiens__NP_000132

<400>  4037

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  4038
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR3__Homo_sapiens__NP_000133

<400>  4038

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  4039
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR4__Homo_sapiens__NP_001278909

<400>  4039

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Ser Ser Pro 
        355                 360                 365             


Trp Ser Gln Ala Leu Pro Ala Ser Gln Ala His Pro Trp Tyr Glu Ala 
    370                 375                 380                 


Cys Val Ser Pro Pro Ala Ala Pro Pro Cys Ser Pro Ala Ser Leu Val 
385                 390                 395                 400 


Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg Ala 
                405                 410                 415     


Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln Ala Ser Thr Val 
            420                 425                 430         


Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala Asp 
        435                 440                 445             


Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys Asn 
    450                 455                 460                 


Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr Val 
465                 470                 475                 480 


Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg Ala 
                485                 490                 495     


Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser Ser 
            500                 505                 510         


Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys Ala Tyr Gln Val 
        515                 520                 525             


Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg Asp 
    530                 535                 540                 


Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile 
545                 550                 555                 560 


Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr Lys 
                565                 570                 575     


Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala 
            580                 585                 590         


Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly 
        595                 600                 605             


Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly 
    610                 615                 620                 


Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg Met 
625                 630                 635                 640 


Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly Leu Met Arg Glu 
                645                 650                 655     


Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val 
            660                 665                 670         


Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu Asp 
        675                 680                 685             


Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly Gly Asp Ala Ser 
    690                 695                 700                 


Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu Pro 
705                 710                 715                 720 


Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val Gln Thr 
                725                 730                 


<210>  4040
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFRL1__Homo_sapiens__NP_001004358

<400>  4040

Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu 
1               5                   10                  15      


Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala 
            20                  25                  30          


Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg 
        35                  40                  45              


Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr 
    50                  55                  60                  


Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu 
65                  70                  75                  80  


Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val 
                85                  90                  95      


Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr 
            100                 105                 110         


Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly 
        115                 120                 125             


Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp 
    130                 135                 140                 


Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile 
145                 150                 155                 160 


Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly 
                165                 170                 175     


His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr 
            180                 185                 190         


Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu 
        195                 200                 205             


Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser 
    210                 215                 220                 


Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln 
225                 230                 235                 240 


Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr 
                245                 250                 255     


Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser 
            260                 265                 270         


Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala 
        275                 280                 285             


Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val 
    290                 295                 300                 


Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu 
305                 310                 315                 320 


Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr 
                325                 330                 335     


Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe 
            340                 345                 350         


Leu Thr Val Leu Pro Asp Pro Lys Pro Pro Gly Pro Pro Val Ala Ser 
        355                 360                 365             


Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro 
    370                 375                 380                 


Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln 
385                 390                 395                 400 


Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly 
                405                 410                 415     


His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu 
            420                 425                 430         


Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu 
        435                 440                 445             


Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro 
    450                 455                 460                 


Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr 
465                 470                 475                 480 


His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val 
                485                 490                 495     


His Gln His Ile His Tyr Gln Cys 
            500                 


<210>  4041
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGG__Homo_sapiens__NP_000500

<400>  4041

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Lys Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Ala Gly Asp Val 
        435         


<210>  4042
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGGY__Homo_sapiens__XP_011540039

<400>  4042

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15      


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30          


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45              


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60                  


Val Thr Lys Lys Val Val Gln Gly Ile Asp Leu Asn Gln Ile Arg Gly 
65                  70                  75                  80  


Leu Gly Phe Asp Ala Thr Cys Ser Leu Val Val Leu Asp Lys Gln Phe 
                85                  90                  95      


His Pro Leu Pro Val Asn Gln Glu Gly Asp Ser His Arg Asn Val Ile 
            100                 105                 110         


Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
        115                 120                 125             


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
    130                 135                 140                 


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
145                 150                 155                 160 


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
                165                 170                 175     


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
            180                 185                 190         


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
        195                 200                 205             


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
    210                 215                 220                 


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
225                 230                 235                 240 


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
                245                 250                 255     


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
            260                 265                 270         


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
        275                 280                 285             


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
    290                 295                 300                 


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
305                 310                 315                 320 


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
                325                 330                 335     


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
            340                 345                 350         


Val Lys Ala Thr Ala Arg Ser Pro Asp 
        355                 360     


<210>  4043
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGL1__Homo_sapiens__NP_004458

<400>  4043

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  4044
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGL2__Homo_sapiens__NP_006673

<400>  4044

Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr 
1               5                   10                  15      


Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp 
            20                  25                  30          


Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys 
        35                  40                  45              


Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu 
    50                  55                  60                  


Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys 
                85                  90                  95      


Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn 
            100                 105                 110         


Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn 
        115                 120                 125             


Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu 
    130                 135                 140                 


Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys 
145                 150                 155                 160 


Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys 
                165                 170                 175     


Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser 
            180                 185                 190         


Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Val Gln His Leu 
        195                 200                 205             


Ile Tyr Lys Asp Cys Ser Asp Tyr Tyr Ala Ile Gly Lys Arg Ser Ser 
    210                 215                 220                 


Glu Thr Tyr Arg Val Thr Pro Asp Pro Lys Asn Ser Ser Phe Glu Val 
225                 230                 235                 240 


Tyr Cys Asp Met Glu Thr Met Gly Gly Gly Trp Thr Val Leu Gln Ala 
                245                 250                 255     


Arg Leu Asp Gly Ser Thr Asn Phe Thr Arg Thr Trp Gln Asp Tyr Lys 
            260                 265                 270         


Ala Gly Phe Gly Asn Leu Arg Arg Glu Phe Trp Leu Gly Asn Asp Lys 
        275                 280                 285             


Ile His Leu Leu Thr Lys Ser Lys Glu Met Ile Leu Arg Ile Asp Leu 
    290                 295                 300                 


Glu Asp Phe Asn Gly Val Glu Leu Tyr Ala Leu Tyr Asp Gln Phe Tyr 
305                 310                 315                 320 


Val Ala Asn Glu Phe Leu Lys Tyr Arg Leu His Val Gly Asn Tyr Asn 
                325                 330                 335     


Gly Thr Ala Gly Asp Ala Leu Arg Phe Asn Lys His Tyr Asn His Asp 
            340                 345                 350         


Leu Lys Phe Phe Thr Thr Pro Asp Lys Asp Asn Asp Arg Tyr Pro Ser 
        355                 360                 365             


Gly Asn Cys Gly Leu Tyr Tyr Ser Ser Gly Trp Trp Phe Asp Ala Cys 
    370                 375                 380                 


Leu Ser Ala Asn Leu Asn Gly Lys Tyr Tyr His Gln Lys Tyr Arg Gly 
385                 390                 395                 400 


Val Arg Asn Gly Ile Phe Trp Gly Thr Trp Pro Gly Val Ser Glu Ala 
                405                 410                 415     


His Pro Gly Gly Tyr Lys Ser Ser Phe Lys Glu Ala Lys Met Met Ile 
            420                 425                 430         


Arg Pro Lys His Phe Lys Pro 
        435                 


<210>  4045
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGR__Homo_sapiens__XP_011539313

<400>  4045

Met Gly Cys Val Phe Cys Lys Lys Leu Glu Pro Val Ala Thr Ala Lys 
1               5                   10                  15      


Glu Asp Ala Gly Leu Glu Gly Asp Phe Arg Ser Tyr Gly Ala Ala Asp 
            20                  25                  30          


His Tyr Gly Pro Asp Pro Thr Lys Ala Arg Pro Ala Ser Ser Phe Ala 
        35                  40                  45              


His Ile Pro Asn Tyr Ser Asn Phe Ser Ser Gln Ala Ile Asn Pro Gly 
    50                  55                  60                  


Phe Leu Asp Ser Gly Thr Ile Arg Gly Val Ser Val Lys Val Thr Gly 
65                  70                  75                  80  


Gly Arg Leu Gly Leu Ser Ala Pro Glu Lys Leu Ala Ala Phe Pro Ala 
                85                  90                  95      


Thr Thr Trp Pro Leu Leu Thr Gln Ser Lys Leu Lys Ser Ala Tyr Ser 
            100                 105                 110         


Leu Ser Ile Arg Asp Trp Asp Gln Thr Arg Gly Asp His Val Lys His 
        115                 120                 125             


Tyr Lys Ile Arg Lys Leu Asp Met Gly Gly Tyr Tyr Ile Thr Thr Arg 
    130                 135                 140                 


Val Gln Phe Asn Ser Val Gln Glu Leu Val Gln His Tyr Met Glu Val 
145                 150                 155                 160 


Asn Asp Gly Leu Cys Asn Leu Leu Ile Ala Pro Cys Thr Ile Met Lys 
                165                 170                 175     


Pro Gln Thr Leu Gly Leu Ala Lys Asp Ala Trp Glu Ile Ser Arg Ser 
            180                 185                 190         


Ser Ile Thr Leu Glu Arg Arg Leu Gly Thr Gly Cys Phe Gly Asp Val 
        195                 200                 205             


Trp Leu Gly Thr Trp Asn Gly Ser Thr Lys Val Ala Val Lys Thr Leu 
    210                 215                 220                 


Lys Pro Gly Thr Met Ser Pro Lys Ala Phe Leu Glu Glu Ala Gln Val 
225                 230                 235                 240 


Met Lys Leu Leu Arg His Asp Lys Leu Val Gln Leu Tyr Ala Val Val 
                245                 250                 255     


Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Cys His Gly Ser 
            260                 265                 270         


Leu Leu Asp Phe Leu Lys Asn Pro Glu Gly Gln Asp Leu Arg Leu Pro 
        275                 280                 285             


Gln Leu Val Asp Met Ala Ala Gln Val Ala Glu Gly Met Ala Tyr Met 
    290                 295                 300                 


Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu 
305                 310                 315                 320 


Val Gly Glu Arg Leu Ala Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg 
                325                 330                 335     


Leu Ile Lys Asp Asp Glu Tyr Asn Pro Cys Gln Gly Ser Lys Phe Pro 
            340                 345                 350         


Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Phe Gly Arg Phe Thr Ile 
        355                 360                 365             


Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Ile Thr 
    370                 375                 380                 


Lys Gly Arg Ile Pro Tyr Pro Gly Met Asn Lys Arg Glu Val Leu Glu 
385                 390                 395                 400 


Gln Val Glu Gln Gly Tyr His Met Pro Cys Pro Pro Gly Cys Pro Ala 
                405                 410                 415     


Ser Leu Tyr Glu Ala Met Glu Gln Thr Trp Arg Leu Asp Pro Glu Glu 
            420                 425                 430         


Arg Pro Thr Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr 
        435                 440                 445             


Ser Ala Glu Pro Gln Tyr Gln Pro Gly Asp Gln Thr 
    450                 455                 460 


<210>  4046
<211>  1143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHDC1__Homo_sapiens__NP_203751

<400>  4046

Met His Val Met Asn Cys Val Ser Leu Val Ser Asp Lys Glu Asn Gly 
1               5                   10                  15      


Asn Ile Ala Thr Ala Pro Gly Phe Met Ile Gly Gln Thr Pro Pro Pro 
            20                  25                  30          


Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Pro Pro Cys Ser 
        35                  40                  45              


Cys Ser Arg Glu Glu Cys Pro Ser Ser Pro Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Leu Pro Gly Glu Pro Pro Ile Pro Pro Pro Pro Pro Gly Leu Pro 
65                  70                  75                  80  


Pro Thr Thr His Met Asn Gly Tyr Ser His Leu Gly Lys Lys Lys Arg 
                85                  90                  95      


Met Arg Ser Phe Phe Trp Lys Thr Ile Pro Glu Glu Gln Val Arg Gly 
            100                 105                 110         


Lys Thr Asn Ile Trp Thr Leu Ala Ala Arg Gln Glu His His Tyr Gln 
        115                 120                 125             


Ile Asp Thr Lys Thr Ile Glu Glu Leu Phe Gly Gln Gln Glu Asp Thr 
    130                 135                 140                 


Thr Lys Ser Ser Leu Pro Arg Arg Gly Arg Thr Leu Asn Ser Ser Phe 
145                 150                 155                 160 


Arg Glu Ala Arg Glu Glu Ile Thr Ile Leu Asp Ala Lys Arg Ser Met 
                165                 170                 175     


Asn Ile Gly Ile Phe Leu Lys Gln Phe Lys Lys Ser Pro Arg Ser Ile 
            180                 185                 190         


Val Glu Asp Ile His Gln Gly Lys Ser Glu His Tyr Gly Ser Glu Thr 
        195                 200                 205             


Leu Arg Glu Phe Leu Lys Phe Leu Pro Glu Ser Glu Glu Val Lys Lys 
    210                 215                 220                 


Leu Lys Ala Phe Ser Gly Asp Val Ser Lys Leu Ser Leu Ala Asp Ser 
225                 230                 235                 240 


Phe Leu Tyr Gly Leu Ile Gln Val Pro Asn Tyr Ser Leu Arg Ile Glu 
                245                 250                 255     


Ala Met Val Leu Lys Lys Glu Phe Leu Pro Ser Cys Ser Ser Leu Tyr 
            260                 265                 270         


Thr Asp Ile Thr Val Leu Arg Thr Ala Ile Lys Glu Leu Met Ser Cys 
        275                 280                 285             


Glu Glu Leu His Ser Ile Leu His Leu Val Leu Gln Ala Gly Asn Ile 
    290                 295                 300                 


Met Asn Ala Gly Gly Tyr Ala Gly Asn Ala Val Gly Phe Lys Leu Ser 
305                 310                 315                 320 


Ser Leu Leu Lys Leu Ala Asp Thr Lys Ala Asn Lys Pro Gly Met Asn 
                325                 330                 335     


Leu Leu His Phe Val Ala Gln Glu Ala Gln Lys Lys Asp Thr Ile Leu 
            340                 345                 350         


Leu Asn Phe Ser Glu Lys Leu His His Val Gln Lys Thr Ala Arg Leu 
        355                 360                 365             


Ser Leu Glu Asn Thr Glu Ala Glu Leu His Leu Leu Phe Val Arg Thr 
    370                 375                 380                 


Lys Ser Leu Lys Glu Asn Ile Gln Arg Asp Gly Glu Leu Cys Gln Gln 
385                 390                 395                 400 


Met Glu Asp Phe Leu Gln Phe Ala Ile Glu Lys Leu Arg Glu Leu Glu 
                405                 410                 415     


Cys Trp Lys Gln Glu Leu Gln Asp Glu Ala Tyr Thr Leu Ile Asp Phe 
            420                 425                 430         


Phe Cys Glu Asp Lys Lys Thr Met Lys Leu Asp Glu Cys Phe Gln Ile 
        435                 440                 445             


Phe Arg Asp Phe Cys Thr Lys Phe Asn Lys Ala Val Lys Asp Asn His 
    450                 455                 460                 


Asp Arg Glu Ala Gln Glu Leu Arg Gln Leu Gln Arg Leu Lys Glu Gln 
465                 470                 475                 480 


Glu Gln Lys Gln Arg Ser Trp Ala Thr Gly Glu Leu Gly Ala Phe Gly 
                485                 490                 495     


Arg Ser Ser Ser Glu Asn Asp Val Glu Leu Leu Thr Lys Lys Gly Ala 
            500                 505                 510         


Glu Gly Leu Leu Pro Phe Leu His Pro Arg Pro Ile Ser Pro Ser Ser 
        515                 520                 525             


Pro Ser Tyr Arg Pro Pro Asn Thr Arg Arg Ser Arg Leu Ser Leu Gly 
    530                 535                 540                 


Pro Ser Ala Asp Arg Glu Leu Leu Thr Phe Leu Glu Ser Ser Thr Gly 
545                 550                 555                 560 


Ser Pro Glu Glu Pro Asn Lys Phe His Ser Leu Pro Arg Ser Ser Pro 
                565                 570                 575     


Arg Gln Ala Arg Pro Thr Ile Ala Cys Leu Glu Pro Ala Glu Val Arg 
            580                 585                 590         


His Gln Asp Ser Ser Phe Ala His Lys Pro Gln Ala Ser Gly Gly Gln 
        595                 600                 605             


Glu Glu Ala Pro Asn Pro Pro Ser Ala Gln Ala His Gln Leu Ala Ala 
    610                 615                 620                 


Ala Gln Pro Glu Asn His Ala Ser Ala Phe Pro Arg Ala Arg Arg Gln 
625                 630                 635                 640 


Gly Val Ser Val Leu Arg Lys Arg Tyr Ser Glu Pro Val Ser Leu Gly 
                645                 650                 655     


Ser Ala Gln Ser Pro Pro Leu Ser Pro Leu Ala Leu Gly Ile Lys Glu 
            660                 665                 670         


His Glu Leu Val Thr Gly Leu Ala Gln Phe Asn Leu Gln Gly Ser Gln 
        675                 680                 685             


Gly Met Glu Glu Thr Ser Gln Leu Thr Leu Ser Asp Phe Ser Pro Met 
    690                 695                 700                 


Glu Leu Glu Ser Val Gly His Arg Gly Pro Gln Ser Leu Ser Ala Ser 
705                 710                 715                 720 


Ser Ser Ser Leu Thr Pro Met Gly Arg Asp Ala Leu Gly Ser Leu Ser 
                725                 730                 735     


Pro Ala Leu Glu Asp Gly Lys Ala Ala Pro Asp Glu Pro Gly Ser Ala 
            740                 745                 750         


Ala Leu Gly Ser Val Gly Ser Ser Asp Pro Glu Asn Lys Asp Pro Arg 
        755                 760                 765             


Pro Leu Phe Cys Ile Ser Asp Thr Thr Asp Cys Ser Leu Thr Leu Asp 
    770                 775                 780                 


Cys Ser Glu Gly Thr Asp Ser Arg Pro Arg Gly Gly Asp Pro Glu Glu 
785                 790                 795                 800 


Gly Gly Glu Gly Asp Gly Ser Met Ser Ser Gly Val Gly Glu Met Gly 
                805                 810                 815     


Asp Ser Gln Val Ser Ser Asn Pro Thr Ser Ser Pro Pro Gly Glu Ala 
            820                 825                 830         


Pro Ala Pro Val Ser Val Asp Ser Glu Pro Ser Cys Lys Gly Gly Leu 
        835                 840                 845             


Pro Arg Asp Lys Pro Thr Lys Arg Lys Asp Val Val Ala Pro Lys Arg 
    850                 855                 860                 


Gly Ser Leu Lys Glu Ala Ser Pro Gly Ala Ser Lys Pro Gly Ser Ala 
865                 870                 875                 880 


Arg Arg Ser Gln Gly Ala Val Ala Lys Ser Val Arg Thr Leu Thr Ala 
                885                 890                 895     


Ser Glu Asn Glu Ser Met Arg Lys Val Met Pro Ile Thr Lys Ser Ser 
            900                 905                 910         


Arg Gly Ala Gly Trp Arg Arg Pro Glu Leu Ser Ser Arg Gly Pro Ser 
        915                 920                 925             


Gln Asn Pro Pro Ser Ser Thr Asp Thr Val Trp Ser Arg Gln Asn Ser 
    930                 935                 940                 


Val Arg Arg Ala Ser Thr Gly Ala Glu Glu Gln Arg Leu Pro Arg Gly 
945                 950                 955                 960 


Ser Ser Gly Ser Ser Ser Thr Arg Pro Gly Arg Asp Val Pro Leu Gln 
                965                 970                 975     


Pro Arg Gly Ser Phe Lys Lys Pro Ser Ala Lys Pro Leu Arg Asn Leu 
            980                 985                 990         


Pro Arg Gln Lys Pro Glu Glu Asn  Lys Thr Cys Arg Ala  His Ser Glu 
        995                 1000                 1005             


Gly Pro  Glu Ser Pro Lys Glu  Glu Pro Lys Thr Pro  Ser Val Pro 
    1010                 1015                 1020             


Ser Val  Pro His Glu Leu Pro  Arg Val Pro Ser Phe  Ala Arg Asn 
    1025                 1030                 1035             


Thr Val  Ala Ser Ser Ser Arg  Ser Met Arg Thr Asp  Leu Pro Pro 
    1040                 1045                 1050             


Val Ala  Lys Ala Pro Gly Ile  Thr Arg Thr Val Ser  Gln Arg Gln 
    1055                 1060                 1065             


Leu Arg  Val Lys Gly Asp Pro  Glu Asp Ala Ala Pro  Lys Asp Ser 
    1070                 1075                 1080             


Ser Thr  Leu Arg Arg Ala Ser  Ser Ala Arg Ala Pro  Lys Lys Arg 
    1085                 1090                 1095             


Pro Glu  Ser Ala Glu Gly Pro  Ser Ala Asn Thr Glu  Ala Pro Leu 
    1100                 1105                 1110             


Lys Ala  Arg Gly Ala Gly Glu  Arg Ala Ser Leu Arg  Arg Lys Asp 
    1115                 1120                 1125             


Ser Ser  Arg Thr Thr Leu Gly  Arg Ile Leu Asn Pro  Leu Arg Lys 
    1130                 1135                 1140             


<210>  4047
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH__Homo_sapiens__NP_000134

<400>  4047

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15      


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30          


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn 
        35                  40                  45              


Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn 
    50                  55                  60                  


Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys 
65                  70                  75                  80  


Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe 
                85                  90                  95      


Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu 
            100                 105                 110         


Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala 
        115                 120                 125             


Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
    130                 135                 140                 


Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg 
145                 150                 155                 160 


Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His 
                165                 170                 175     


Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro 
            180                 185                 190         


Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu 
        195                 200                 205             


Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu 
    210                 215                 220                 


Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val 
225                 230                 235                 240 


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val Lys 
                245                 250                 255     


Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu Leu 
            260                 265                 270         


Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile Gly 
        275                 280                 285             


Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu Pro 
    290                 295                 300                 


Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
305                 310                 315                 320 


Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu Met 
                325                 330                 335     


Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser Gly 
            340                 345                 350         


Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
        355                 360                 365             


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Ala 
    370                 375                 380                 


Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser Asn 
385                 390                 395                 400 


Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn Val 
                405                 410                 415     


Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr Glu 
            420                 425                 430         


Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys Leu 
        435                 440                 445             


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
    450                 455                 460                 


Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly Ser 
465                 470                 475                 480 


Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu Gln 
                485                 490                 495     


Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys 
            500                 505                 510 


<210>  4048
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHIT__Homo_sapiens__NP_002003

<400>  4048

Met Ser Phe Arg Phe Gly Gln His Leu Ile Lys Pro Ser Val Val Phe 
1               5                   10                  15      


Leu Lys Thr Glu Leu Ser Phe Ala Leu Val Asn Arg Lys Pro Val Val 
            20                  25                  30          


Pro Gly His Val Leu Val Cys Pro Leu Arg Pro Val Glu Arg Phe His 
        35                  40                  45              


Asp Leu Arg Pro Asp Glu Val Ala Asp Leu Phe Gln Thr Thr Gln Arg 
    50                  55                  60                  


Val Gly Thr Val Val Glu Lys His Phe His Gly Thr Ser Leu Thr Phe 
65                  70                  75                  80  


Ser Met Gln Asp Gly Pro Glu Ala Gly Gln Thr Val Lys His Val His 
                85                  90                  95      


Val His Val Leu Pro Arg Lys Ala Gly Asp Phe His Arg Asn Asp Ser 
            100                 105                 110         


Ile Tyr Glu Glu Leu Gln Lys His Asp Lys Glu Asp Phe Pro Ala Ser 
        115                 120                 125             


Trp Arg Ser Glu Glu Glu Met Ala Ala Glu Ala Ala Ala Leu Arg Val 
    130                 135                 140                 


Tyr Phe Gln 
145         


<210>  4049
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHL1__Homo_sapiens__NP_001153171

<400>  4049

Met Ala Ser His Arg His Ser Gly Pro Ser Ser Tyr Lys Val Gly Thr 
1               5                   10                  15      


Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
            20                  25                  30          


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
        35                  40                  45              


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
    50                  55                  60                  


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
65                  70                  75                  80  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
                85                  90                  95      


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
            100                 105                 110         


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
        115                 120                 125             


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
    130                 135                 140                 


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
145                 150                 155                 160 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
                165                 170                 175     


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
            180                 185                 190         


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
        195                 200                 205             


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
    210                 215                 220                 


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
225                 230                 235                 240 


Lys Asn Pro Ile Thr Gly Phe Gly Lys Gly Ser Ser Val Val Ala Tyr 
                245                 250                 255     


Glu Gly Gln Ser Trp His Asp Tyr Cys Phe His Cys Lys Lys Cys Ser 
            260                 265                 270         


Val Asn Leu Ala Asn Lys Arg Phe Val Phe His Gln Glu Gln Val Tyr 
        275                 280                 285             


Cys Pro Asp Cys Ala Lys Lys Leu 
    290                 295     


<210>  4050
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHL2__Homo_sapiens__XP_005263959

<400>  4050

Met Thr Arg Arg Gly Phe Ser Arg Ala Gly Ala Ala Gln Arg Ser Thr 
1               5                   10                  15      


Arg Pro Ala Ala Glu Pro Gln Pro Pro Ala Ala Arg Ala Leu Gln Pro 
            20                  25                  30          


Arg Pro Gly Val Pro Gly Pro Leu Arg Cys Arg Glu Tyr Leu Gln Pro 
        35                  40                  45              


Pro Ala Pro Arg Arg Glu Ala Glu Gly Leu Ser His Gln Gly Ser Glu 
    50                  55                  60                  


Val Gly Ala Glu Ser Gly Ala Arg Pro Lys Glu Arg Gly Ala Glu Pro 
65                  70                  75                  80  


Glu Leu Gly Arg Leu Trp Leu Arg Thr Val Ser Ser Trp Arg Leu Gly 
                85                  90                  95      


Trp His Phe Asp Phe Gly Val Ala Glu Lys Pro Gly Val Lys Met Thr 
            100                 105                 110         


Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly Lys Lys 
        115                 120                 125             


Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe Glu Thr 
    130                 135                 140                 


Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly Cys Asp 
145                 150                 155                 160 


Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala Cys Phe 
                165                 170                 175     


His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe Ala Ala 
            180                 185                 190         


Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu Tyr Ser 
        195                 200                 205             


Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr Arg Lys 
    210                 215                 220                 


Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile Cys His 
225                 230                 235                 240 


Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys Asp Asn 
                245                 250                 255     


Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met Gln Cys 
            260                 265                 270         


Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr Arg Glu 
        275                 280                 285             


Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg Lys Gln 
    290                 295                 300                 


Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr Cys Leu 
305                 310                 315                 320 


Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys Thr Asn 
                325                 330                 335     


Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu Glu Arg 
            340                 345                 350         


Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu Ser Leu 
        355                 360                 365             


Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys Pro Asp 
    370                 375                 380                 


Cys Gly Lys Asp Ile 
385                 


<210>  4051
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHL5__Homo_sapiens__XP_006715676

<400>  4051

Met Thr Thr Ala His Phe Tyr Cys Gln Tyr Cys Thr Ala Ser Leu Leu 
1               5                   10                  15      


Gly Lys Lys Tyr Val Leu Lys Asp Asp Ser Pro Tyr Cys Val Thr Cys 
            20                  25                  30          


Tyr Asp Arg Val Phe Ser Asn Tyr Cys Glu Glu Cys Lys Lys Pro Ile 
        35                  40                  45              


Glu Ser Asp Ser Lys Asp Leu Cys Tyr Lys Asp Arg His Trp His Glu 
    50                  55                  60                  


Gly Cys Phe Lys Cys Thr Lys Cys Asn His Ser Leu Val Glu Lys Pro 
65                  70                  75                  80  


Phe Ala Ala Lys Asp Glu Arg Leu Leu Cys Thr Glu Cys Tyr Ser Asn 
                85                  90                  95      


Glu Cys Ser Ser Lys Cys Phe His Cys Lys Arg Thr Ile Met Pro Gly 
            100                 105                 110         


Ser Arg Lys Met Glu Phe Lys Gly Asn Tyr Trp His Glu Thr Cys Phe 
        115                 120                 125             


Val Cys Glu Asn Cys Arg Gln Pro Ile Gly Thr Lys Pro Leu Ile Ser 
    130                 135                 140                 


Lys Glu Ser Gly Asn Tyr Cys Val Pro Cys Phe Glu Lys Glu Phe Ala 
145                 150                 155                 160 


His Tyr Cys Asn Phe Cys Lys Lys Val Ile Thr Ser Gly Gly Ile Thr 
                165                 170                 175     


Phe Cys Asp Gln Leu Trp His Lys Glu Cys Phe Leu Cys Ser Gly Cys 
            180                 185                 190         


Arg Lys Asp Leu Cys Glu Glu Gln Phe Met Ser Arg Asp Asp Tyr Pro 
        195                 200                 205             


Phe Cys Val Asp Cys Tyr Asn His Leu Tyr Ala Asn Lys Cys Val Ala 
    210                 215                 220                 


Cys Ser Lys Pro Ile Ser Gly Leu Thr Gly Ala Lys Phe Ile Cys Phe 
225                 230                 235                 240 


Gln Asp Ser Gln Trp His Ser Glu Cys Phe Asn Cys Gly Lys Cys Ser 
                245                 250                 255     


Val Ser Leu Val Gly Lys Gly Phe Leu Thr Gln Asn Lys Glu Ile Phe 
            260                 265                 270         


Cys Gln Lys Cys Gly Ser Gly Met Asp Thr Asp Ile 
        275                 280                 


<210>  4052
<211>  1164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHOD1__Homo_sapiens__NP_037373

<400>  4052

Met Ala Gly Gly Glu Asp Arg Gly Asp Gly Glu Pro Val Ser Val Val 
1               5                   10                  15      


Thr Val Arg Val Gln Tyr Leu Glu Asp Thr Asp Pro Phe Ala Cys Ala 
            20                  25                  30          


Asn Phe Pro Glu Pro Arg Arg Ala Pro Thr Cys Ser Leu Asp Gly Ala 
        35                  40                  45              


Leu Pro Leu Gly Ala Gln Ile Pro Ala Val His Arg Leu Leu Gly Ala 
    50                  55                  60                  


Pro Leu Lys Leu Glu Asp Cys Ala Leu Gln Val Ser Pro Ser Gly Tyr 
65                  70                  75                  80  


Tyr Leu Asp Thr Glu Leu Ser Leu Glu Glu Gln Arg Glu Met Leu Glu 
                85                  90                  95      


Gly Phe Tyr Glu Glu Ile Ser Lys Gly Arg Lys Pro Thr Leu Ile Leu 
            100                 105                 110         


Arg Thr Gln Leu Ser Val Arg Val Asn Ala Ile Leu Glu Lys Leu Tyr 
        115                 120                 125             


Ser Ser Ser Gly Pro Glu Leu Arg Arg Ser Leu Phe Ser Leu Lys Gln 
    130                 135                 140                 


Ile Phe Gln Glu Asp Lys Asp Leu Val Pro Glu Phe Val His Ser Glu 
145                 150                 155                 160 


Gly Leu Ser Cys Leu Ile Arg Val Gly Ala Ala Ala Asp His Asn Tyr 
                165                 170                 175     


Gln Ser Tyr Ile Leu Arg Ala Leu Gly Gln Leu Met Leu Phe Val Asp 
            180                 185                 190         


Gly Met Leu Gly Val Val Ala His Ser Asp Thr Ile Gln Trp Leu Tyr 
        195                 200                 205             


Thr Leu Cys Ala Ser Leu Ser Arg Leu Val Val Lys Thr Ala Leu Lys 
    210                 215                 220                 


Leu Leu Leu Val Phe Val Glu Tyr Ser Glu Asn Asn Ala Pro Leu Phe 
225                 230                 235                 240 


Ile Arg Ala Val Asn Ser Val Ala Ser Thr Thr Gly Ala Pro Pro Trp 
                245                 250                 255     


Ala Asn Leu Val Ser Ile Leu Glu Glu Lys Asn Gly Ala Asp Pro Glu 
            260                 265                 270         


Leu Leu Val Tyr Thr Val Thr Leu Ile Asn Lys Thr Leu Ala Ala Leu 
        275                 280                 285             


Pro Asp Gln Asp Ser Phe Tyr Asp Val Thr Asp Ala Leu Glu Gln Gln 
    290                 295                 300                 


Gly Met Glu Ala Leu Val Gln Arg His Leu Gly Thr Ala Gly Thr Asp 
305                 310                 315                 320 


Val Asp Leu Arg Thr Gln Leu Val Leu Tyr Glu Asn Ala Leu Lys Leu 
                325                 330                 335     


Glu Asp Gly Asp Ile Glu Glu Ala Pro Gly Ala Gly Gly Arg Arg Glu 
            340                 345                 350         


Arg Arg Lys Pro Ser Ser Glu Glu Gly Lys Arg Ser Arg Arg Ser Leu 
        355                 360                 365             


Glu Gly Gly Gly Cys Pro Ala Arg Ala Pro Glu Pro Gly Pro Thr Gly 
    370                 375                 380                 


Pro Ala Ser Pro Val Gly Pro Thr Ser Ser Thr Gly Pro Ala Leu Leu 
385                 390                 395                 400 


Thr Gly Pro Ala Ser Ser Pro Val Gly Pro Pro Ser Gly Leu Gln Ala 
                405                 410                 415     


Ser Val Asn Leu Phe Pro Thr Ile Ser Val Ala Pro Ser Ala Asp Thr 
            420                 425                 430         


Ser Ser Glu Arg Ser Ile Tyr Lys Ala Arg Phe Leu Glu Asn Val Ala 
        435                 440                 445             


Ala Ala Glu Thr Glu Lys Gln Val Ala Leu Ala Gln Gly Arg Ala Glu 
    450                 455                 460                 


Thr Leu Ala Gly Ala Met Pro Asn Glu Ala Gly Gly His Pro Asp Ala 
465                 470                 475                 480 


Arg Gln Leu Trp Asp Ser Pro Glu Thr Ala Pro Ala Ala Arg Thr Pro 
                485                 490                 495     


Gln Ser Pro Ala Pro Cys Val Leu Leu Arg Ala Gln Arg Ser Leu Ala 
            500                 505                 510         


Pro Glu Pro Lys Glu Pro Leu Ile Pro Ala Ser Pro Lys Ala Glu Pro 
        515                 520                 525             


Ile Trp Glu Leu Pro Thr Arg Ala Pro Arg Leu Ser Ile Gly Asp Leu 
    530                 535                 540                 


Asp Phe Ser Asp Leu Gly Glu Asp Glu Asp Gln Asp Met Leu Asn Val 
545                 550                 555                 560 


Glu Ser Val Glu Ala Gly Lys Asp Ile Pro Ala Pro Ser Pro Pro Leu 
                565                 570                 575     


Pro Leu Leu Ser Gly Val Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro 
            580                 585                 590         


Pro Ile Lys Gly Pro Phe Pro Pro Pro Pro Pro Leu Pro Leu Ala Ala 
        595                 600                 605             


Pro Leu Pro His Ser Val Pro Asp Ser Ser Ala Leu Pro Thr Lys Arg 
    610                 615                 620                 


Lys Thr Val Lys Leu Phe Trp Arg Glu Leu Lys Leu Ala Gly Gly His 
625                 630                 635                 640 


Gly Val Ser Ala Ser Arg Phe Gly Pro Cys Ala Thr Leu Trp Ala Ser 
                645                 650                 655     


Leu Asp Pro Val Ser Val Asp Thr Ala Arg Leu Glu His Leu Phe Glu 
            660                 665                 670         


Ser Arg Ala Lys Glu Val Leu Pro Ser Lys Lys Ala Gly Glu Gly Arg 
        675                 680                 685             


Arg Thr Met Thr Thr Val Leu Asp Pro Lys Arg Ser Asn Ala Ile Asn 
    690                 695                 700                 


Ile Gly Leu Thr Thr Leu Pro Pro Val His Val Ile Lys Ala Ala Leu 
705                 710                 715                 720 


Leu Asn Phe Asp Glu Phe Ala Val Ser Lys Asp Gly Ile Glu Lys Leu 
                725                 730                 735     


Leu Thr Met Met Pro Thr Glu Glu Glu Arg Gln Lys Ile Glu Glu Ala 
            740                 745                 750         


Gln Leu Ala Asn Pro Asp Ile Pro Leu Gly Pro Ala Glu Asn Phe Leu 
        755                 760                 765             


Met Thr Leu Ala Ser Ile Gly Gly Leu Ala Ala Arg Leu Gln Leu Trp 
    770                 775                 780                 


Ala Phe Lys Leu Asp Tyr Asp Ser Met Glu Arg Glu Ile Ala Glu Pro 
785                 790                 795                 800 


Leu Phe Asp Leu Lys Val Gly Met Glu Gln Leu Val Gln Asn Ala Thr 
                805                 810                 815     


Phe Arg Cys Ile Leu Ala Thr Leu Leu Ala Val Gly Asn Phe Leu Asn 
            820                 825                 830         


Gly Ser Gln Ser Ser Gly Phe Glu Leu Ser Tyr Leu Glu Lys Val Ser 
        835                 840                 845             


Glu Val Lys Asp Thr Val Arg Arg Gln Ser Leu Leu His His Leu Cys 
    850                 855                 860                 


Ser Leu Val Leu Gln Thr Arg Pro Glu Ser Ser Asp Leu Tyr Ser Glu 
865                 870                 875                 880 


Ile Pro Ala Leu Thr Arg Cys Ala Lys Val Asp Phe Glu Gln Leu Thr 
                885                 890                 895     


Glu Asn Leu Gly Gln Leu Glu Arg Arg Ser Arg Ala Ala Glu Glu Ser 
            900                 905                 910         


Leu Arg Ser Leu Ala Lys His Glu Leu Ala Pro Ala Leu Arg Ala Arg 
        915                 920                 925             


Leu Thr His Phe Leu Asp Gln Cys Ala Arg Arg Val Ala Met Leu Arg 
    930                 935                 940                 


Ile Val His Arg Arg Val Cys Asn Arg Phe His Ala Phe Leu Leu Tyr 
945                 950                 955                 960 


Leu Gly Tyr Thr Pro Gln Ala Ala Arg Glu Val Arg Ile Met Gln Phe 
                965                 970                 975     


Cys His Thr Leu Arg Glu Phe Ala Leu Glu Tyr Arg Thr Cys Arg Glu 
            980                 985                 990         


Arg Val Leu Gln Gln Gln Gln Lys  Gln Ala Thr Tyr Arg  Glu Arg Asn 
        995                 1000                 1005             


Lys Thr  Arg Gly Arg Met Ile  Thr Glu Thr Glu Lys  Phe Ser Gly 
    1010                 1015                 1020             


Val Ala  Gly Glu Ala Pro Ser  Asn Pro Ser Val Pro  Val Ala Val 
    1025                 1030                 1035             


Ser Ser  Gly Pro Gly Arg Gly  Asp Ala Asp Ser His  Ala Ser Met 
    1040                 1045                 1050             


Lys Ser  Leu Leu Thr Ser Arg  Pro Glu Asp Thr Thr  His Asn Arg 
    1055                 1060                 1065             


Arg Ser  Arg Gly Met Val Gln  Ser Ser Ser Pro Ile  Met Pro Thr 
    1070                 1075                 1080             


Val Gly  Pro Ser Thr Ala Ser  Pro Glu Glu Pro Pro  Gly Ser Ser 
    1085                 1090                 1095             


Leu Pro  Ser Asp Thr Ser Asp  Glu Ile Met Asp Leu  Leu Val Gln 
    1100                 1105                 1110             


Ser Val  Thr Lys Ser Ser Pro  Arg Ala Leu Ala Ala  Arg Glu Arg 
    1115                 1120                 1125             


Lys Arg  Ser Arg Gly Asn Arg  Lys Ser Leu Arg Arg  Thr Leu Lys 
    1130                 1135                 1140             


Ser Gly  Leu Gly Asp Asp Leu  Val Gln Ala Leu Gly  Leu Ser Lys 
    1145                 1150                 1155             


Gly Pro  Gly Leu Glu Val 
    1160                 


<210>  4053
<211>  1422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHOD3__Homo_sapiens__NP_001268668

<400>  4053

Met Ala Thr Leu Ala Cys Arg Val Gln Phe Leu Asp Asp Thr Asp Pro 
1               5                   10                  15      


Phe Asn Ser Thr Asn Phe Pro Glu Pro Ser Arg Pro Pro Leu Phe Thr 
            20                  25                  30          


Phe Arg Glu Asp Leu Ala Leu Gly Thr Gln Leu Ala Gly Val His Arg 
        35                  40                  45              


Leu Leu Gln Ala Pro His Lys Leu Asp Asp Cys Thr Leu Gln Leu Ser 
    50                  55                  60                  


His Asn Gly Ala Tyr Leu Asp Leu Glu Ala Thr Leu Ala Glu Gln Arg 
65                  70                  75                  80  


Asp Glu Leu Glu Gly Phe Gln Asp Asp Ala Gly Arg Gly Lys Lys His 
                85                  90                  95      


Ser Ile Ile Leu Arg Thr Gln Leu Ser Val Arg Val His Ala Cys Ile 
            100                 105                 110         


Glu Lys Leu Tyr Asn Ser Ser Gly Arg Asp Leu Arg Arg Ala Leu Phe 
        115                 120                 125             


Ser Leu Lys Gln Ile Phe Gln Asp Asp Lys Asp Leu Val His Glu Phe 
    130                 135                 140                 


Val Val Ala Glu Gly Leu Thr Cys Leu Ile Lys Val Gly Ala Glu Ala 
145                 150                 155                 160 


Asp Gln Asn Tyr Gln Asn Tyr Ile Leu Arg Ala Leu Gly Gln Ile Met 
                165                 170                 175     


Leu Tyr Val Asp Gly Met Asn Gly Val Ile Asn Arg Asn Glu Thr Ile 
            180                 185                 190         


Gln Trp Leu Tyr Thr Leu Ile Gly Ser Lys Phe Arg Leu Val Val Lys 
        195                 200                 205             


Thr Ala Leu Lys Leu Leu Leu Val Phe Val Glu Tyr Ser Glu Ser Asn 
    210                 215                 220                 


Ala Pro Leu Leu Ile Gln Ala Val Thr Ala Val Asp Thr Lys Arg Gly 
225                 230                 235                 240 


Val Lys Pro Trp Ser Asn Ile Met Glu Ile Leu Glu Glu Lys Asp Gly 
                245                 250                 255     


Val Asp Thr Glu Leu Leu Val Tyr Ala Met Thr Leu Val Asn Lys Thr 
            260                 265                 270         


Leu Ser Gly Leu Pro Asp Gln Asp Thr Phe Tyr Asp Val Val Asp Cys 
        275                 280                 285             


Leu Glu Glu Leu Gly Ile Ala Ala Val Ser Gln Arg His Leu Asn Lys 
    290                 295                 300                 


Lys Gly Thr Asp Leu Asp Leu Val Glu Gln Leu Asn Ile Tyr Glu Val 
305                 310                 315                 320 


Ala Leu Arg His Glu Asp Gly Asp Glu Thr Thr Glu Pro Pro Pro Ser 
                325                 330                 335     


Gly Cys Arg Asp Arg Arg Arg Ala Ser Val Cys Ser Ser Gly Gly Gly 
            340                 345                 350         


Glu His Arg Gly Leu Asp Arg Arg Arg Ser Arg Arg His Ser Val Gln 
        355                 360                 365             


Ser Ile Lys Ser Thr Leu Ser Ala Pro Thr Ser Pro Cys Ser Gln Ser 
    370                 375                 380                 


Ala Pro Ser Phe Lys Pro Asn Gln Val Arg Asp Leu Arg Glu Lys Tyr 
385                 390                 395                 400 


Ser Asn Phe Gly Asn Asn Ser Tyr His Ser Ser Arg Pro Ser Ser Gly 
                405                 410                 415     


Ser Ser Val Pro Thr Thr Pro Thr Ser Ser Val Ser Pro Pro Gln Glu 
            420                 425                 430         


Ala Arg Leu Glu Arg Ser Ser Pro Ser Gly Leu Leu Thr Ser Ser Phe 
        435                 440                 445             


Arg Gln His Gln Glu Ser Leu Ala Ala Glu Arg Glu Arg Arg Arg Gln 
    450                 455                 460                 


Glu Arg Glu Glu Arg Leu Gln Arg Ile Glu Arg Glu Glu Arg Asn Lys 
465                 470                 475                 480 


Phe Arg Tyr Lys Tyr Leu Glu Gln Leu Ala Ala Glu Glu His Glu Lys 
                485                 490                 495     


Glu Leu Arg Ser Arg Ser Val Ser Arg Gly Arg Ala Asp Leu Ser Leu 
            500                 505                 510         


Asp Leu Thr Ser Pro Ala Ala Pro Ala Cys Leu Ala Pro Leu Ser His 
        515                 520                 525             


Ser Pro Ser Ser Ser Asp Ser Gln Glu Ala Leu Thr Val Ser Ala Ser 
    530                 535                 540                 


Ser Pro Gly Thr Pro His His Pro Gln Ala Ser Ala Gly Asp Pro Glu 
545                 550                 555                 560 


Pro Glu Ser Glu Ala Glu Pro Glu Ala Glu Ala Gly Ala Gly Gln Val 
                565                 570                 575     


Ala Asp Glu Ala Gly Gln Asp Ile Ala Ser Ala His Glu Gly Ala Glu 
            580                 585                 590         


Thr Glu Val Glu Gln Ala Leu Glu Gln Glu Pro Glu Glu Arg Ala Ser 
        595                 600                 605             


Leu Ser Glu Lys Glu Arg Gln Asn Glu Gly Val Asn Glu Arg Asp Asn 
    610                 615                 620                 


Cys Ser Ala Ser Ser Val Ser Ser Ser Ser Ser Thr Leu Glu Arg Glu 
625                 630                 635                 640 


Glu Lys Glu Asp Lys Leu Ser Arg Asp Arg Thr Thr Gly Leu Trp Pro 
                645                 650                 655     


Ala Gly Val Gln Asp Ala Gly Val Asn Gly Gln Cys Gly Asp Ile Leu 
            660                 665                 670         


Thr Asn Lys Arg Phe Met Leu Asp Met Leu Tyr Ala His Asn Arg Lys 
        675                 680                 685             


Ser Pro Asp Asp Glu Glu Lys Gly Asp Gly Glu Ala Gly Arg Thr Gln 
    690                 695                 700                 


Gln Glu Ala Glu Ala Val Ala Ser Leu Ala Thr Arg Ile Ser Thr Leu 
705                 710                 715                 720 


Gln Ala Asn Ser Gln Thr Gln Asp Glu Ser Val Arg Arg Val Asp Val 
                725                 730                 735     


Gly Cys Leu Asp Asn Arg Gly Ser Val Lys Ala Phe Ala Glu Lys Phe 
            740                 745                 750         


Asn Ser Gly Asp Leu Gly Arg Gly Ser Ile Ser Pro Asp Ala Glu Pro 
        755                 760                 765             


Asn Asp Lys Val Pro Glu Thr Ala Pro Val Gln Pro Lys Thr Glu Ser 
    770                 775                 780                 


Asp Tyr Ile Trp Asp Gln Leu Met Ala Asn Pro Arg Glu Leu Arg Ile 
785                 790                 795                 800 


Gln Asp Met Asp Phe Thr Asp Leu Gly Glu Glu Asp Asp Ile Asp Val 
                805                 810                 815     


Leu Asp Val Asp Leu Gly His Arg Glu Ala Pro Gly Pro Pro Pro Pro 
            820                 825                 830         


Pro Pro Pro Thr Phe Leu Gly Leu Pro Pro Pro Pro Pro Pro Pro Leu 
        835                 840                 845             


Leu Asp Ser Ile Pro Pro Pro Pro Val Pro Gly Asn Leu Leu Val Pro 
    850                 855                 860                 


Pro Pro Pro Val Phe Asn Ala Pro Gln Gly Leu Gly Trp Ser Gln Val 
865                 870                 875                 880 


Pro Arg Gly Gln Pro Thr Phe Thr Lys Lys Lys Lys Thr Ile Arg Leu 
                885                 890                 895     


Phe Trp Asn Glu Val Arg Pro Phe Asp Trp Pro Cys Lys Asn Asn Arg 
            900                 905                 910         


Arg Cys Arg Glu Phe Leu Trp Ser Lys Leu Glu Pro Ile Lys Val Asp 
        915                 920                 925             


Thr Ser Arg Leu Glu His Leu Phe Glu Ser Lys Ser Lys Glu Leu Ser 
    930                 935                 940                 


Val Ser Lys Lys Thr Ala Ala Asp Gly Lys Arg Gln Glu Ile Ile Val 
945                 950                 955                 960 


Leu Asp Ser Lys Arg Ser Asn Ala Ile Asn Ile Gly Leu Thr Val Leu 
                965                 970                 975     


Pro Pro Pro Arg Thr Ile Lys Ile Ala Ile Leu Asn Phe Asp Glu Tyr 
            980                 985                 990         


Ala Leu Asn Lys Glu Gly Ile Glu  Lys Ile Leu Thr Met  Ile Pro Thr 
        995                 1000                 1005             


Asp Glu  Glu Lys Gln Lys Ile  Gln Glu Ala Gln Leu  Ala Asn Pro 
    1010                 1015                 1020             


Glu Ile  Pro Leu Gly Ser Ala  Glu Gln Phe Leu Leu  Thr Leu Ser 
    1025                 1030                 1035             


Ser Ile  Ser Glu Leu Ser Ala  Arg Leu His Leu Trp  Ala Phe Lys 
    1040                 1045                 1050             


Met Asp  Tyr Glu Thr Thr Glu  Lys Glu Val Ala Glu  Pro Leu Leu 
    1055                 1060                 1065             


Asp Leu  Lys Glu Gly Ile Asp  Gln Leu Glu Asn Asn  Lys Thr Leu 
    1070                 1075                 1080             


Gly Phe  Ile Leu Ser Thr Leu  Leu Ala Ile Gly Asn  Phe Leu Asn 
    1085                 1090                 1095             


Gly Thr  Asn Ala Lys Ala Phe  Glu Leu Ser Tyr Leu  Glu Lys Val 
    1100                 1105                 1110             


Pro Glu  Val Lys Asp Thr Val  His Lys Gln Ser Leu  Leu His His 
    1115                 1120                 1125             


Val Cys  Thr Met Val Val Glu  Asn Phe Pro Asp Ser  Ser Asp Leu 
    1130                 1135                 1140             


Tyr Ser  Glu Ile Gly Ala Ile  Thr Arg Ser Ala Lys  Val Asp Phe 
    1145                 1150                 1155             


Asp Gln  Leu Gln Asp Asn Leu  Cys Gln Met Glu Arg  Arg Cys Lys 
    1160                 1165                 1170             


Ala Ser  Trp Asp His Leu Lys  Ala Ile Ala Lys His  Glu Met Lys 
    1175                 1180                 1185             


Pro Val  Leu Lys Gln Arg Met  Ser Glu Phe Leu Lys  Asp Cys Ala 
    1190                 1195                 1200             


Glu Arg  Ile Ile Ile Leu Lys  Ile Val His Arg Arg  Ile Ile Asn 
    1205                 1210                 1215             


Arg Phe  His Ser Phe Leu Leu  Phe Met Gly His Pro  Pro Tyr Ala 
    1220                 1225                 1230             


Ile Arg  Glu Val Asn Ile Asn  Lys Phe Cys Arg Ile  Ile Ser Glu 
    1235                 1240                 1245             


Phe Ala  Leu Glu Tyr Arg Thr  Thr Arg Glu Arg Val  Leu Gln Gln 
    1250                 1255                 1260             


Lys Gln  Lys Arg Ala Asn His  Arg Glu Arg Asn Lys  Thr Arg Gly 
    1265                 1270                 1275             


Lys Met  Ile Thr Asp Ser Gly  Lys Phe Ser Gly Ser  Ser Pro Ala 
    1280                 1285                 1290             


Pro Pro  Ser Gln Pro Gln Gly  Leu Ser Tyr Ala Glu  Asp Ala Ala 
    1295                 1300                 1305             


Glu His  Glu Asn Met Lys Ala  Val Leu Lys Thr Ser  Ser Pro Ser 
    1310                 1315                 1320             


Val Glu  Asp Ala Thr Pro Ala  Leu Gly Val Arg Thr  Arg Ser Arg 
    1325                 1330                 1335             


Ala Ser  Arg Gly Ser Thr Ser  Ser Trp Thr Met Gly  Thr Asp Asp 
    1340                 1345                 1350             


Ser Pro  Asn Val Thr Asp Asp  Ala Ala Asp Glu Ile  Met Asp Arg 
    1355                 1360                 1365             


Ile Val  Lys Ser Ala Thr Gln  Val Pro Ser Gln Arg  Val Val Pro 
    1370                 1375                 1380             


Arg Glu  Arg Lys Arg Ser Arg  Ala Asn Arg Lys Ser  Leu Arg Arg 
    1385                 1390                 1395             


Thr Leu  Lys Ser Gly Leu Thr  Pro Glu Glu Ala Arg  Ala Leu Gly 
    1400                 1405                 1410             


Leu Val  Gly Thr Ser Glu Leu  Gln Leu 
    1415                 1420         


<210>  4054
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIBP__Homo_sapiens__NP_004205

<400>  4054

Met Thr Ser Glu Leu Asp Ile Phe Val Gly Asn Thr Thr Leu Ile Asp 
1               5                   10                  15      


Glu Asp Val Tyr Arg Leu Trp Leu Asp Gly Tyr Ser Val Thr Asp Ala 
            20                  25                  30          


Val Ala Leu Arg Val Arg Ser Gly Ile Leu Glu Gln Thr Gly Ala Thr 
        35                  40                  45              


Ala Ala Val Leu Gln Ser Asp Thr Met Asp His Tyr Arg Thr Phe His 
    50                  55                  60                  


Met Leu Glu Arg Leu Leu His Ala Pro Pro Lys Leu Leu His Gln Leu 
65                  70                  75                  80  


Ile Phe Gln Ile Pro Pro Ser Arg Gln Ala Leu Leu Ile Glu Arg Tyr 
                85                  90                  95      


Tyr Ala Phe Asp Glu Ala Phe Val Arg Glu Val Leu Gly Lys Lys Leu 
            100                 105                 110         


Ser Lys Gly Thr Lys Lys Asp Leu Asp Asp Ile Ser Thr Lys Thr Gly 
        115                 120                 125             


Ile Thr Leu Lys Ser Cys Arg Arg Gln Phe Asp Asn Phe Lys Arg Val 
    130                 135                 140                 


Phe Lys Val Val Glu Glu Met Arg Gly Ser Leu Val Asp Asn Ile Gln 
145                 150                 155                 160 


Gln His Phe Leu Leu Ser Asp Arg Leu Ala Arg Asp Tyr Ala Ala Ile 
                165                 170                 175     


Val Phe Phe Ala Asn Asn Arg Phe Glu Thr Gly Lys Lys Lys Leu Gln 
            180                 185                 190         


Tyr Leu Ser Phe Gly Asp Phe Ala Phe Cys Ala Glu Leu Met Ile Gln 
        195                 200                 205             


Asn Trp Thr Leu Gly Ala Val Asp Ser Gln Met Asp Asp Met Asp Met 
    210                 215                 220                 


Asp Leu Asp Lys Glu Phe Leu Gln Asp Leu Lys Glu Leu Lys Val Leu 
225                 230                 235                 240 


Val Ala Asp Lys Asp Leu Leu Asp Leu His Lys Ser Leu Val Cys Thr 
                245                 250                 255     


Ala Leu Arg Gly Lys Leu Gly Val Phe Ser Glu Met Glu Ala Asn Phe 
            260                 265                 270         


Lys Asn Leu Ser Arg Gly Leu Val Asn Val Ala Ala Lys Leu Thr His 
        275                 280                 285             


Asn Lys Asp Val Arg Asp Leu Phe Val Asp Leu Val Glu Lys Phe Val 
    290                 295                 300                 


Glu Pro Cys Arg Ser Asp His Trp Pro Leu Ser Asp Val Arg Phe Phe 
305                 310                 315                 320 


Leu Asn Gln Tyr Ser Ala Ser Val His Ser Leu Asp Gly Phe Arg His 
                325                 330                 335     


Gln Ala Leu Trp Asp Arg Tyr Met Gly Thr Leu Arg Gly Cys Leu Leu 
            340                 345                 350         


Arg Leu Tyr His Asp 
        355         


<210>  4055
<211>  907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIG4__Homo_sapiens__NP_055660

<400>  4055

Met Pro Thr Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala 
            20                  25                  30          


Glu Thr Lys Tyr Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Ile Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Gly Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Val Glu 
        115                 120                 125             


Asp Thr Asn Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Val Thr His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Met Thr Gln Asn Arg Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Ile Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Cys Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Ser 
225                 230                 235                 240 


Thr Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Lys Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Tyr Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Val Ala Ala Leu His Phe Asp Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Thr Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Ile Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly Cys Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Arg Leu 
    610                 615                 620                 


Leu Pro Thr Arg Arg Ser Tyr Thr Tyr Trp Trp Thr Pro Glu Val Ile 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Val Asn Leu 
                645                 650                 655     


Lys Lys Leu Ile Val Lys Lys Phe His Lys Tyr Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Val Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Ser Asn Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Glu 
        755                 760                 765             


Glu Gly Ser Val Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Ala 
    770                 775                 780                 


Gly Asp Ser Ala Lys Val Thr Glu Asn Val Val Gln Pro Met Lys Glu 
785                 790                 795                 800 


Leu Tyr Gly Ile Asn Leu Ser Asp Gly Leu Ser Glu Glu Asp Phe Ser 
                805                 810                 815     


Ile Tyr Ser Arg Phe Val Gln Leu Gly Gln Ser Gln His Lys Gln Asp 
            820                 825                 830         


Lys Asn Ser Gln Gln Pro Cys Ser Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Ser Ser 
                885                 890                 895     


Met Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


<210>  4056
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIGF__Homo_sapiens__NP_004460

<400>  4056

Met Tyr Arg Glu Trp Val Val Val Asn Val Phe Met Met Leu Tyr Val 
1               5                   10                  15      


Gln Leu Val Gln Gly Ser Ser Asn Glu His Gly Pro Val Lys Arg Ser 
            20                  25                  30          


Ser Gln Ser Thr Leu Glu Arg Ser Glu Gln Gln Ile Arg Ala Ala Ser 
        35                  40                  45              


Ser Leu Glu Glu Leu Leu Arg Ile Thr His Ser Glu Asp Trp Lys Leu 
    50                  55                  60                  


Trp Arg Cys Arg Leu Arg Leu Lys Ser Phe Thr Ser Met Asp Ser Arg 
65                  70                  75                  80  


Ser Ala Ser His Arg Ser Thr Arg Phe Ala Ala Thr Phe Tyr Asp Ile 
                85                  90                  95      


Glu Thr Leu Lys Val Ile Asp Glu Glu Trp Gln Arg Thr Gln Cys Ser 
            100                 105                 110         


Pro Arg Glu Thr Cys Val Glu Val Ala Ser Glu Leu Gly Lys Ser Thr 
        115                 120                 125             


Asn Thr Phe Phe Lys Pro Pro Cys Val Asn Val Phe Arg Cys Gly Gly 
    130                 135                 140                 


Cys Cys Asn Glu Glu Ser Leu Ile Cys Met Asn Thr Ser Thr Ser Tyr 
145                 150                 155                 160 


Ile Ser Lys Gln Leu Phe Glu Ile Ser Val Pro Leu Thr Ser Val Pro 
                165                 170                 175     


Glu Leu Val Pro Val Lys Val Ala Asn His Thr Gly Cys Lys Cys Leu 
            180                 185                 190         


Pro Thr Ala Pro Arg His Pro Tyr Ser Ile Ile Arg Arg Ser Ile Gln 
        195                 200                 205             


Ile Pro Glu Glu Asp Arg Cys Ser His Ser Lys Lys Leu Cys Pro Ile 
    210                 215                 220                 


Asp Met Leu Trp Asp Ser Asn Lys Cys Lys Cys Val Leu Gln Glu Glu 
225                 230                 235                 240 


Asn Pro Leu Ala Gly Thr Glu Asp His Ser His Leu Gln Glu Pro Ala 
                245                 250                 255     


Leu Cys Gly Pro His Met Met Phe Asp Glu Asp Arg Cys Glu Cys Val 
            260                 265                 270         


Cys Lys Thr Pro Cys Pro Lys Asp Leu Ile Gln His Pro Lys Asn Cys 
        275                 280                 285             


Ser Cys Phe Glu Cys Lys Glu Ser Leu Glu Thr Cys Cys Gln Lys His 
    290                 295                 300                 


Lys Leu Phe His Pro Asp Thr Cys Ser Cys Glu Asp Arg Cys Pro Phe 
305                 310                 315                 320 


His Thr Arg Pro Cys Ala Ser Gly Lys Thr Ala Cys Ala Lys His Cys 
                325                 330                 335     


Arg Phe Pro Lys Glu Lys Arg Ala Ala Gln Gly Pro His Ser Arg Lys 
            340                 345                 350         


Asn Pro 
        


<210>  4057
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIGLA__Homo_sapiens__NP_001004311

<400>  4057

Met Asp Pro Ala Pro Gly Val Leu Asp Pro Arg Ala Ala Pro Pro Ala 
1               5                   10                  15      


Leu Leu Gly Thr Pro Gln Ala Glu Val Leu Glu Asp Val Leu Arg Glu 
            20                  25                  30          


Gln Phe Gly Pro Leu Pro Gln Leu Ala Ala Val Cys Arg Leu Lys Arg 
        35                  40                  45              


Leu Pro Ser Gly Gly Tyr Ser Ser Thr Glu Asn Leu Gln Leu Val Leu 
    50                  55                  60                  


Glu Arg Arg Arg Val Ala Asn Ala Lys Glu Arg Glu Arg Ile Lys Asn 
65                  70                  75                  80  


Leu Asn Arg Gly Phe Ala Arg Leu Lys Ala Leu Val Pro Phe Leu Pro 
                85                  90                  95      


Gln Ser Arg Lys Pro Ser Lys Val Asp Ile Leu Lys Gly Ala Thr Glu 
            100                 105                 110         


Tyr Ile Gln Val Leu Ser Asp Leu Leu Glu Gly Ala Lys Asp Ser Lys 
        115                 120                 125             


Lys Gln Asp Pro Asp Glu Gln Ser Tyr Ser Asn Asn Ser Ser Glu Ser 
    130                 135                 140                 


His Thr Ser Ser Ala Arg Gln Leu Ser Arg Asn Ile Thr Gln His Ile 
145                 150                 155                 160 


Ser Cys Ala Phe Gly Leu Lys Asn Glu Glu Glu Gly Pro Trp Ala Asp 
                165                 170                 175     


Gly Gly Ser Gly Glu Pro Ala His Ala Cys Arg His Ser Val Met Ser 
            180                 185                 190         


Thr Thr Glu Ile Ile Ser Pro Thr Arg Ser Leu Asp Arg Phe Pro Glu 
        195                 200                 205             


Val Glu Leu Leu Ser His Arg Leu Pro Gln Val 
    210                 215                 


<210>  4058
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIGN__Homo_sapiens__NP_060556

<400>  4058

Met Ile Ser Ser Thr Ser Val Tyr Gly Leu Lys Met Gln Trp Thr Pro 
1               5                   10                  15      


Glu His Ala Gln Trp Pro Glu Gln His Phe Asp Ile Thr Ser Thr Thr 
            20                  25                  30          


Arg Ser Pro Ala His Lys Val Glu Ala Tyr Arg Gly His Leu Gln Arg 
        35                  40                  45              


Thr Tyr Gln Tyr Ala Trp Ala Asn Asp Asp Ile Ser Ala Leu Thr Ala 
    50                  55                  60                  


Ser Asn Leu Leu Lys Lys Tyr Ala Glu Lys Tyr Ser Gly Ile Leu Glu 
65                  70                  75                  80  


Gly Pro Val Asp Arg Pro Val Leu Ser Asn Tyr Ser Asp Thr Pro Ser 
                85                  90                  95      


Gly Leu Val Asn Gly Arg Lys Asn Glu Ser Glu Pro Trp Gln Pro Ser 
            100                 105                 110         


Leu Asn Ser Glu Ala Val Tyr Pro Met Asn Cys Val Pro Asp Val Ile 
        115                 120                 125             


Thr Ala Ser Lys Ala Gly Val Ser Ser Ala Leu Pro Pro Ala Asp Val 
    130                 135                 140                 


Ser Ala Ser Ile Gly Ser Ser Pro Gly Val Ala Ser Asn Leu Thr Glu 
145                 150                 155                 160 


Pro Ser Tyr Ser Ser Ser Thr Cys Gly Ser His Thr Val Pro Ser Leu 
                165                 170                 175     


His Ala Gly Leu Pro Ser Gln Glu Tyr Ala Pro Gly Tyr Asn Gly Ser 
            180                 185                 190         


Tyr Leu His Ser Thr Tyr Ser Ser Gln Pro Ala Pro Ala Leu Pro Ser 
        195                 200                 205             


Pro His Pro Ser Pro Leu His Ser Ser Gly Leu Leu Gln Pro Pro Pro 
    210                 215                 220                 


Pro Pro Pro Pro Pro Pro Ala Leu Val Pro Gly Tyr Asn Gly Thr Ser 
225                 230                 235                 240 


Asn Leu Ser Ser Tyr Ser Tyr Pro Ser Ala Ser Tyr Pro Pro Gln Thr 
                245                 250                 255     


Ala Val Gly Ser Gly Tyr Ser Pro Gly Gly Ala Pro Pro Pro Pro Ser 
            260                 265                 270         


Ala Tyr Leu Pro Ser Gly Ile Pro Ala Pro Thr Pro Leu Pro Pro Thr 
        275                 280                 285             


Thr Val Pro Gly Tyr Thr Tyr Gln Gly His Gly Leu Thr Pro Ile Ala 
    290                 295                 300                 


Pro Ser Ala Leu Thr Asn Ser Ser Ala Ser Ser Leu Lys Arg Lys Ala 
305                 310                 315                 320 


Phe Tyr Met Ala Gly Gln Gly Asp Met Asp Ser Ser Tyr Gly Asn Tyr 
                325                 330                 335     


Ser Tyr Gly Gln Gln Arg Ser Thr Gln Ser Pro Met Tyr Arg Met Pro 
            340                 345                 350         


Asp Asn Ser Ile Ser Asn Thr Asn Arg Gly Asn Gly Phe Asp Arg Ser 
        355                 360                 365             


Ala Glu Thr Ser Ser Leu Ala Phe Lys Pro Thr Lys Gln Leu Met Ser 
    370                 375                 380                 


Ser Glu Gln Gln Arg Lys Phe Ser Ser Gln Ser Ser Arg Ala Leu Thr 
385                 390                 395                 400 


Pro Pro Ser Tyr Ser Thr Ala Lys Asn Ser Leu Gly Ser Arg Ser Ser 
                405                 410                 415     


Glu Ser Phe Gly Lys Tyr Thr Ser Pro Val Met Ser Glu His Gly Asp 
            420                 425                 430         


Glu His Arg Gln Leu Leu Ser His Pro Met Gln Gly Pro Gly Leu Arg 
        435                 440                 445             


Ala Ala Thr Ser Ser Asn His Ser Val Asp Glu Gln Leu Lys Asn Thr 
    450                 455                 460                 


Asp Thr His Leu Ile Asp Leu Val Thr Asn Glu Ile Ile Thr Gln Gly 
465                 470                 475                 480 


Pro Pro Val Asp Trp Asn Asp Ile Ala Gly Leu Asp Leu Val Lys Ala 
                485                 490                 495     


Val Ile Lys Glu Glu Val Leu Trp Pro Val Leu Arg Ser Asp Ala Phe 
            500                 505                 510         


Ser Gly Leu Thr Ala Leu Pro Arg Ser Ile Leu Leu Phe Gly Pro Arg 
        515                 520                 525             


Gly Thr Gly Lys Thr Leu Leu Gly Arg Cys Ile Ala Ser Gln Leu Gly 
    530                 535                 540                 


Ala Thr Phe Phe Lys Ile Ala Gly Ser Gly Leu Val Ala Lys Trp Leu 
545                 550                 555                 560 


Gly Glu Ala Glu Lys Ile Ile His Ala Ser Phe Leu Val Ala Arg Cys 
                565                 570                 575     


Arg Gln Pro Ser Val Ile Phe Val Ser Asp Ile Asp Met Leu Leu Ser 
            580                 585                 590         


Ser Gln Val Asn Glu Glu His Ser Pro Val Ser Arg Met Arg Thr Glu 
        595                 600                 605             


Phe Leu Met Gln Leu Asp Thr Val Leu Thr Ser Ala Glu Asp Gln Ile 
    610                 615                 620                 


Val Val Ile Cys Ala Thr Ser Lys Pro Glu Glu Ile Asp Glu Ser Leu 
625                 630                 635                 640 


Arg Arg Tyr Phe Met Lys Arg Leu Leu Ile Pro Leu Pro Asp Ser Thr 
                645                 650                 655     


Ala Arg His Gln Ile Ile Val Gln Leu Leu Ser Gln His Asn Tyr Cys 
            660                 665                 670         


Leu Asn Asp Lys Glu Phe Ala Leu Leu Val Gln Arg Thr Glu Gly Phe 
        675                 680                 685             


Ser Gly Leu Asp Val Ala His Leu Cys Gln Glu Ala Val Val Gly Pro 
    690                 695                 700                 


Leu His Ala Met Pro Ala Thr Asp Leu Ser Ala Ile Met Pro Ser Gln 
705                 710                 715                 720 


Leu Arg Pro Val Thr Tyr Gln Asp Phe Glu Asn Ala Phe Cys Lys Ile 
                725                 730                 735     


Gln Pro Ser Ile Ser Gln Lys Glu Leu Asp Met Tyr Val Glu Trp Asn 
            740                 745                 750         


Lys Met Phe Gly Cys Ser Gln 
        755                 


<210>  4059
<211>  1216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FILIP1__Homo_sapiens__NP_001276916

<400>  4059

Met Val Gly Met Arg Ser Arg Asn Gln Gly Gly Glu Ser Ala Ser Asp 
1               5                   10                  15      


Gly His Ile Ser Cys Pro Lys Pro Ser Ile Ile Gly Asn Ala Gly Glu 
            20                  25                  30          


Lys Ser Leu Ser Glu Asp Ala Lys Lys Lys Lys Lys Ser Asn Arg Lys 
        35                  40                  45              


Glu Asp Asp Val Met Ala Ser Gly Thr Val Lys Arg His Leu Lys Thr 
    50                  55                  60                  


Ser Gly Glu Cys Glu Arg Lys Thr Lys Lys Ser Leu Glu Leu Ser Lys 
65                  70                  75                  80  


Glu Asp Leu Ile Gln Leu Leu Ser Ile Met Glu Gly Glu Leu Gln Ala 
                85                  90                  95      


Arg Glu Asp Val Ile His Met Leu Lys Thr Glu Lys Thr Lys Pro Glu 
            100                 105                 110         


Val Leu Glu Ala His Tyr Gly Ser Ala Glu Pro Glu Lys Val Leu Arg 
        115                 120                 125             


Val Leu His Arg Asp Ala Ile Leu Ala Gln Glu Lys Ser Ile Gly Glu 
    130                 135                 140                 


Asp Val Tyr Glu Lys Pro Ile Ser Glu Leu Asp Arg Leu Glu Glu Lys 
145                 150                 155                 160 


Gln Lys Glu Thr Tyr Arg Arg Met Leu Glu Gln Leu Leu Leu Ala Glu 
                165                 170                 175     


Lys Cys His Arg Arg Thr Val Tyr Glu Leu Glu Asn Glu Lys His Lys 
            180                 185                 190         


His Thr Asp Tyr Met Asn Lys Ser Asp Asp Phe Thr Asn Leu Leu Glu 
        195                 200                 205             


Gln Glu Arg Glu Arg Leu Lys Lys Leu Leu Glu Gln Glu Lys Ala Tyr 
    210                 215                 220                 


Gln Ala Arg Lys Glu Lys Glu Asn Ala Lys Arg Leu Asn Lys Leu Arg 
225                 230                 235                 240 


Asp Glu Leu Val Lys Leu Lys Ser Phe Ala Leu Met Leu Val Asp Glu 
                245                 250                 255     


Arg Gln Met His Ile Glu Gln Leu Gly Leu Gln Ser Gln Lys Val Gln 
            260                 265                 270         


Asp Leu Thr Gln Lys Leu Arg Glu Glu Glu Glu Lys Leu Lys Ala Ile 
        275                 280                 285             


Thr Ser Lys Ser Lys Glu Asp Arg Gln Lys Leu Leu Lys Leu Glu Val 
    290                 295                 300                 


Asp Phe Glu His Lys Ala Ser Arg Phe Ser Gln Glu His Glu Glu Met 
305                 310                 315                 320 


Asn Ala Lys Leu Ala Asn Gln Glu Ser His Asn Arg Gln Leu Arg Leu 
                325                 330                 335     


Lys Leu Val Gly Leu Thr Gln Arg Ile Glu Glu Leu Glu Glu Thr Asn 
            340                 345                 350         


Lys Asn Leu Gln Lys Ala Glu Glu Glu Leu Gln Glu Leu Arg Asp Lys 
        355                 360                 365             


Ile Ala Lys Gly Glu Cys Gly Asn Ser Ser Leu Met Ala Glu Val Glu 
    370                 375                 380                 


Asn Leu Arg Lys Arg Val Leu Glu Met Glu Gly Lys Asp Glu Glu Ile 
385                 390                 395                 400 


Thr Lys Thr Glu Ser Gln Cys Arg Glu Leu Arg Lys Lys Leu Gln Glu 
                405                 410                 415     


Glu Glu His His Ser Lys Glu Leu Arg Leu Glu Val Glu Lys Leu Gln 
            420                 425                 430         


Lys Arg Met Ser Glu Leu Glu Lys Leu Glu Glu Ala Phe Ser Lys Ser 
        435                 440                 445             


Lys Ser Glu Cys Thr Gln Leu His Leu Asn Leu Glu Lys Glu Lys Asn 
    450                 455                 460                 


Leu Thr Lys Asp Leu Leu Asn Glu Leu Glu Val Val Lys Ser Arg Val 
465                 470                 475                 480 


Lys Glu Leu Glu Cys Ser Glu Ser Arg Leu Glu Lys Ala Glu Leu Ser 
                485                 490                 495     


Leu Lys Asp Asp Leu Thr Lys Leu Lys Ser Phe Thr Val Met Leu Val 
            500                 505                 510         


Asp Glu Arg Lys Asn Met Met Glu Lys Ile Lys Gln Glu Glu Arg Lys 
        515                 520                 525             


Val Asp Gly Leu Asn Lys Asn Phe Lys Val Glu Gln Gly Lys Val Met 
    530                 535                 540                 


Asp Val Thr Glu Lys Leu Ile Glu Glu Ser Lys Lys Leu Leu Lys Leu 
545                 550                 555                 560 


Lys Ser Glu Met Glu Glu Lys Val Tyr Asn Leu Thr Arg Glu Arg Asp 
                565                 570                 575     


Glu Leu Ile Gly Lys Leu Lys Ser Glu Glu Glu Lys Ser Ser Glu Leu 
            580                 585                 590         


Ser Cys Ser Val Asp Leu Leu Lys Lys Arg Leu Asp Gly Ile Glu Glu 
        595                 600                 605             


Val Glu Arg Glu Ile Thr Arg Gly Arg Ser Arg Lys Gly Ser Glu Leu 
    610                 615                 620                 


Thr Cys Pro Glu Asp Asn Lys Ile Lys Glu Leu Thr Leu Glu Ile Glu 
625                 630                 635                 640 


Arg Leu Lys Lys Arg Leu Gln Gln Leu Glu Val Val Glu Gly Asp Leu 
                645                 650                 655     


Met Lys Thr Glu Asp Glu Tyr Asp Gln Leu Glu Gln Lys Phe Arg Thr 
            660                 665                 670         


Glu Gln Asp Lys Ala Asn Phe Leu Ser Gln Gln Leu Glu Glu Ile Lys 
        675                 680                 685             


His Gln Ile Ala Lys Asn Lys Ala Ile Glu Lys Gly Glu Val Val Ser 
    690                 695                 700                 


Gln Glu Ala Glu Leu Arg His Arg Phe Arg Leu Glu Glu Ala Lys Ser 
705                 710                 715                 720 


Arg Asp Leu Lys Ala Glu Val Gln Ala Leu Lys Glu Lys Ile His Glu 
                725                 730                 735     


Leu Met Asn Lys Glu Asp Gln Leu Ser Gln Leu Gln Val Asp Tyr Ser 
            740                 745                 750         


Val Leu Gln Gln Arg Phe Met Glu Glu Glu Asn Lys Asn Lys Asn Met 
        755                 760                 765             


Gly Gln Glu Val Leu Asn Leu Thr Lys Glu Leu Glu Leu Ser Lys Arg 
    770                 775                 780                 


Tyr Ser Arg Ala Leu Arg Pro Ser Val Asn Gly Arg Arg Met Val Asp 
785                 790                 795                 800 


Val Pro Val Thr Ser Thr Gly Val Gln Thr Asp Ala Val Ser Gly Glu 
                805                 810                 815     


Ala Ala Glu Glu Glu Thr Pro Ala Val Phe Ile Arg Lys Ser Phe Gln 
            820                 825                 830         


Glu Glu Asn His Ile Met Ser Asn Leu Arg Gln Val Gly Leu Lys Lys 
        835                 840                 845             


Pro Val Glu Arg Ser Ser Val Leu Asp Arg Tyr Pro Pro Ala Ala Asn 
    850                 855                 860                 


Glu Leu Thr Met Arg Lys Ser Trp Ile Pro Trp Met Arg Lys Arg Glu 
865                 870                 875                 880 


Asn Gly Pro Ser Ile Thr Gln Glu Lys Gly Pro Arg Thr Asn Ser Ser 
                885                 890                 895     


Pro Gly His Pro Gly Glu Val Val Leu Ser Pro Lys Gln Gly Gln Pro 
            900                 905                 910         


Leu His Ile Arg Val Thr Pro Asp His Glu Asn Ser Thr Ala Thr Leu 
        915                 920                 925             


Glu Ile Thr Ser Pro Thr Ser Glu Glu Phe Phe Ser Ser Thr Thr Val 
    930                 935                 940                 


Ile Pro Thr Leu Gly Asn Gln Lys Pro Arg Ile Thr Ile Ile Pro Ser 
945                 950                 955                 960 


Pro Asn Val Met Pro Gln Lys Gln Lys Ser Gly Asp Thr Thr Leu Gly 
                965                 970                 975     


Pro Glu Arg Ala Met Ser Pro Val Thr Ile Thr Thr Phe Ser Arg Glu 
            980                 985                 990         


Lys Thr Pro Glu Ser Gly Arg Gly  Ala Phe Ala Asp Arg  Pro Thr Ser 
        995                 1000                 1005             


Pro Ile  Gln Ile Met Thr Val  Ser Thr Ser Ala Ala  Pro Ala Glu 
    1010                 1015                 1020             


Ile Ala  Val Ser Pro Glu Ser  Gln Glu Met Pro Met  Gly Arg Thr 
    1025                 1030                 1035             


Ile Leu  Lys Val Thr Pro Glu  Lys Gln Thr Val Pro  Thr Pro Val 
    1040                 1045                 1050             


Arg Lys  Tyr Asn Ser Asn Ala  Asn Ile Ile Thr Thr  Glu Asp Asn 
    1055                 1060                 1065             


Lys Ile  His Ile His Leu Gly  Ser Gln Phe Lys Arg  Ser Pro Gly 
    1070                 1075                 1080             


Thr Ser  Gly Glu Gly Val Ser  Pro Val Ile Thr Val  Arg Pro Val 
    1085                 1090                 1095             


Asn Val  Thr Ala Glu Lys Glu  Val Ser Thr Gly Thr  Val Leu Arg 
    1100                 1105                 1110             


Ser Pro  Arg Asn His Leu Ser  Ser Arg Pro Gly Ala  Ser Lys Val 
    1115                 1120                 1125             


Thr Ser  Thr Ile Thr Ile Thr  Pro Val Thr Thr Ser  Ser Ala Arg 
    1130                 1135                 1140             


Gly Thr  Gln Ser Val Ser Gly  Gln Asp Gly Ser Ser  Gln Arg Pro 
    1145                 1150                 1155             


Thr Pro  Thr Arg Ile Pro Met  Ser Lys Gly Met Lys  Ala Gly Lys 
    1160                 1165                 1170             


Pro Val  Val Ala Ala Pro Gly  Ala Gly Asn Leu Thr  Lys Phe Glu 
    1175                 1180                 1185             


Pro Arg  Ala Glu Thr Gln Ser  Met Lys Ile Glu Leu  Lys Lys Ser 
    1190                 1195                 1200             


Ala Ala  Ser Ser Thr Thr Ser  Leu Gly Gly Gly Lys  Gly 
    1205                 1210                 1215     


<210>  4060
<211>  1133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FILIP1L__Homo_sapiens__NP_001035924

<400>  4060

Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      


Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          


His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              


Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  


Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  


Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      


Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         


Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             


Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 


Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 


Leu Leu Val Ala Glu Lys Ser Arg Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     


Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         


Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             


Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 


Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 


Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     


Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         


Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             


Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 


Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 


Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     


Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         


Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             


Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 


Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 


Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     


Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         


Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             


Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 


Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 


Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     


Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         


Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             


Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 


Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 


Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     


Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         


Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             


Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 


Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 


Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     


Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         


Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             


Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 


Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 


Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     


Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            740                 745                 750         


Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        755                 760                 765             


Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    770                 775                 780                 


Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
785                 790                 795                 800 


Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                805                 810                 815     


Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            820                 825                 830         


Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        835                 840                 845             


Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    850                 855                 860                 


Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
865                 870                 875                 880 


Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                885                 890                 895     


Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            900                 905                 910         


Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        915                 920                 925             


Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    930                 935                 940                 


Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
945                 950                 955                 960 


Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                965                 970                 975     


Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            980                 985                 990         


Leu Thr Pro Glu Arg Thr Met Ser  Pro Ile Gln Val Leu  Ala Val Thr 
        995                 1000                 1005             


Gly Ser  Ala Ser Ser Pro Glu  Gln Gly Arg Ser Pro  Glu Pro Thr 
    1010                 1015                 1020             


Glu Ile  Ser Ala Lys His Ala  Ile Phe Arg Val Ser  Pro Asp Arg 
    1025                 1030                 1035             


Gln Ser  Ser Trp Gln Phe Gln  Arg Ser Asn Ser Asn  Ser Ser Ser 
    1040                 1045                 1050             


Val Ile  Thr Thr Glu Asp Asn  Lys Ile His Ile His  Leu Gly Ser 
    1055                 1060                 1065             


Pro Tyr  Met Gln Ala Val Ala  Ser Pro Val Arg Pro  Ala Ser Pro 
    1070                 1075                 1080             


Ser Ala  Pro Leu Gln Asp Asn  Arg Thr Gln Gly Leu  Ile Asn Gly 
    1085                 1090                 1095             


Ala Leu  Asn Lys Thr Thr Asn  Lys Val Thr Ser Ser  Ile Thr Ile 
    1100                 1105                 1110             


Thr Pro  Thr Ala Thr Pro Leu  Pro Arg Gln Ser Gln  Ile Thr Val 
    1115                 1120                 1125             


Ser Asn  Ile Tyr Asn 
    1130             


<210>  4061
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIP1L1__Homo_sapiens__NP_001128409

<400>  4061

Met Ser Ala Gly Glu Val Glu Arg Leu Val Ser Glu Leu Ser Gly Gly 
1               5                   10                  15      


Thr Gly Gly Asp Glu Glu Glu Glu Trp Leu Tyr Gly Asp Glu Asn Glu 
            20                  25                  30          


Val Glu Arg Pro Glu Glu Glu Asn Ala Ser Ala Asn Pro Pro Ser Gly 
        35                  40                  45              


Ile Glu Asp Glu Thr Ala Glu Asn Gly Val Pro Lys Pro Lys Val Thr 
    50                  55                  60                  


Glu Thr Glu Asp Asp Ser Asp Ser Asp Ser Asp Asp Asp Glu Asp Asp 
65                  70                  75                  80  


Val His Val Thr Ile Gly Asp Ile Lys Thr Gly Ala Pro Gln Tyr Gly 
                85                  90                  95      


Ser Tyr Gly Thr Ala Pro Val Asn Leu Asn Ile Lys Thr Gly Gly Arg 
            100                 105                 110         


Val Tyr Gly Thr Thr Gly Thr Lys Val Lys Gly Val Asp Leu Asp Ala 
        115                 120                 125             


Pro Gly Ser Ile Asn Gly Val Pro Leu Leu Glu Val Asp Leu Asp Ser 
    130                 135                 140                 


Phe Glu Asp Lys Pro Trp Arg Lys Pro Gly Ala Asp Leu Ser Asp Tyr 
145                 150                 155                 160 


Phe Asn Tyr Gly Phe Asn Glu Asp Thr Trp Lys Ala Tyr Cys Glu Lys 
                165                 170                 175     


Gln Lys Arg Ile Arg Met Gly Leu Glu Val Ile Pro Val Thr Ser Thr 
            180                 185                 190         


Thr Asn Lys Ile Thr Ala Glu Asp Cys Thr Met Glu Val Thr Pro Gly 
        195                 200                 205             


Ala Glu Ile Gln Asp Gly Arg Phe Asn Leu Phe Lys Val Gln Gln Gly 
    210                 215                 220                 


Arg Thr Gly Asn Ser Glu Lys Glu Thr Ala Leu Pro Ser Thr Lys Ala 
225                 230                 235                 240 


Glu Phe Thr Ser Pro Pro Ser Leu Phe Lys Thr Gly Leu Pro Pro Ser 
                245                 250                 255     


Arg Asn Ser Thr Ser Ser Gln Ser Gln Thr Ser Thr Ala Ser Arg Lys 
            260                 265                 270         


Ala Asn Ser Ser Val Gly Lys Trp Gln Asp Arg Tyr Gly Arg Ala Glu 
        275                 280                 285             


Ser Pro Asp Leu Arg Arg Leu Pro Gly Ala Ile Asp Val Ile Gly Gln 
    290                 295                 300                 


Thr Ile Thr Ile Ser Arg Val Glu Gly Arg Arg Arg Ala Asn Glu Asn 
305                 310                 315                 320 


Ser Asn Ile Gln Val Leu Ser Glu Arg Ser Ala Thr Glu Val Asp Asn 
                325                 330                 335     


Asn Phe Ser Lys Pro Pro Pro Phe Phe Pro Pro Gly Ala Pro Pro Thr 
            340                 345                 350         


His Leu Pro Pro Pro Pro Phe Leu Pro Pro Pro Pro Thr Val Ser Thr 
        355                 360                 365             


Ala Pro Pro Leu Ile Pro Pro Pro Gly Ile Pro Ile Thr Val Pro Pro 
    370                 375                 380                 


Pro Gly Phe Pro Pro Pro Pro Gly Ala Pro Pro Pro Ser Leu Ile Pro 
385                 390                 395                 400 


Thr Ile Glu Ser Gly His Ser Ser Gly Tyr Asp Ser Arg Ser Ala Arg 
                405                 410                 415     


Ala Phe Pro Tyr Gly Asn Val Ala Phe Pro His Leu Pro Gly Ser Ala 
            420                 425                 430         


Pro Ser Trp Pro Ser Leu Val Asp Thr Ser Lys Gln Trp Asp Tyr Tyr 
        435                 440                 445             


Ala Arg Arg Glu Lys Asp Arg Asp Arg Glu Arg Asp Arg Asp Arg Glu 
    450                 455                 460                 


Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu Arg Thr Arg Glu Arg Glu 
465                 470                 475                 480 


Arg Glu Arg Asp His Ser Pro Thr Pro Ser Val Phe Asn Ser Asp Glu 
                485                 490                 495     


Glu Arg Tyr Arg Tyr Arg Glu Tyr Ala Glu Arg Gly Tyr Glu Arg His 
            500                 505                 510         


Arg Ala Ser Arg Glu Lys Glu Glu Arg His Arg Glu Arg Arg His Arg 
        515                 520                 525             


Glu Lys Glu Glu Thr Arg His Lys Ser Ser Arg Ser Asn Ser Arg Arg 
    530                 535                 540                 


Arg His Glu Ser Glu Glu Gly Asp Ser His Arg Arg His Lys His Lys 
545                 550                 555                 560 


Lys Ser Lys Arg Ser Lys Glu Gly Lys Glu Ala Gly Ser Glu Pro Ala 
                565                 570                 575     


Pro Glu Gln Glu Ser Thr Glu Ala Thr Pro Ala Glu 
            580                 585             


<210>  4062
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIS1__Homo_sapiens__NP_057152

<400>  4062

Met Glu Ala Val Leu Asn Glu Leu Val Ser Val Glu Asp Leu Leu Lys 
1               5                   10                  15      


Phe Glu Lys Lys Phe Gln Ser Glu Lys Ala Ala Gly Ser Val Ser Lys 
            20                  25                  30          


Ser Thr Gln Phe Glu Tyr Ala Trp Cys Leu Val Arg Ser Lys Tyr Asn 
        35                  40                  45              


Asp Asp Ile Arg Lys Gly Ile Val Leu Leu Glu Glu Leu Leu Pro Lys 
    50                  55                  60                  


Gly Ser Lys Glu Glu Gln Arg Asp Tyr Val Phe Tyr Leu Ala Val Gly 
65                  70                  75                  80  


Asn Tyr Arg Leu Lys Glu Tyr Glu Lys Ala Leu Lys Tyr Val Arg Gly 
                85                  90                  95      


Leu Leu Gln Thr Glu Pro Gln Asn Asn Gln Ala Lys Glu Leu Glu Arg 
            100                 105                 110         


Leu Ile Asp Lys Ala Met Lys Lys Asp Gly Leu Val Gly Met Ala Ile 
        115                 120                 125             


Val Gly Gly Met Ala Leu Gly Val Ala Gly Leu Ala Gly Leu Ile Gly 
    130                 135                 140                 


Leu Ala Val Ser Lys Ser Lys Ser 
145                 150         


<210>  4063
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FITM1__Homo_sapiens__NP_981947

<400>  4063

Met Glu Arg Gly Pro Val Val Gly Ala Gly Leu Gly Ala Gly Ala Arg 
1               5                   10                  15      


Ile Gln Ala Leu Leu Gly Cys Leu Leu Lys Val Leu Leu Trp Val Ala 
            20                  25                  30          


Ser Ala Leu Leu Tyr Phe Gly Ser Glu Gln Ala Ala Arg Leu Leu Gly 
        35                  40                  45              


Ser Pro Cys Leu Arg Arg Leu Tyr His Ala Trp Leu Ala Ala Val Val 
    50                  55                  60                  


Ile Phe Gly Pro Leu Leu Gln Phe His Val Asn Pro Arg Thr Ile Phe 
65                  70                  75                  80  


Ala Ser His Gly Asn Phe Phe Asn Ile Lys Phe Val Asn Ser Ala Trp 
                85                  90                  95      


Gly Trp Thr Cys Thr Phe Leu Gly Gly Phe Val Leu Leu Val Val Phe 
            100                 105                 110         


Leu Ala Thr Arg Arg Val Ala Val Thr Ala Arg His Leu Ser Arg Leu 
        115                 120                 125             


Val Val Gly Ala Ala Val Trp Arg Gly Ala Gly Arg Ala Phe Leu Leu 
    130                 135                 140                 


Ile Glu Asp Leu Thr Gly Ser Cys Phe Glu Pro Leu Pro Gln Gly Leu 
145                 150                 155                 160 


Leu Leu His Glu Leu Pro Asp Arg Arg Ser Cys Leu Ala Ala Gly His 
                165                 170                 175     


Gln Trp Arg Gly Tyr Thr Val Ser Ser His Thr Phe Leu Leu Thr Phe 
            180                 185                 190         


Cys Cys Leu Leu Met Ala Glu Glu Ala Ala Val Phe Ala Lys Tyr Leu 
        195                 200                 205             


Ala His Gly Leu Pro Ala Gly Ala Pro Leu Arg Leu Val Phe Leu Leu 
    210                 215                 220                 


Asn Val Leu Leu Leu Gly Leu Trp Asn Phe Leu Leu Leu Cys Thr Val 
225                 230                 235                 240 


Ile Tyr Phe His Gln Tyr Thr His Lys Val Val Gly Ala Ala Val Gly 
                245                 250                 255     


Thr Phe Ala Trp Tyr Leu Thr Tyr Gly Ser Trp Tyr His Gln Pro Trp 
            260                 265                 270         


Ser Pro Gly Ser Pro Gly His Gly Leu Phe Pro Arg Pro His Ser Ser 
        275                 280                 285             


Arg Lys His Asn 
    290         


<210>  4064
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FITM2__Homo_sapiens__NP_001073941

<400>  4064

Met Glu His Leu Glu Arg Cys Glu Trp Leu Leu Arg Gly Thr Leu Val 
1               5                   10                  15      


Arg Ala Ala Val Arg Arg Tyr Leu Pro Trp Ala Leu Val Ala Ser Met 
            20                  25                  30          


Leu Ala Gly Ser Leu Leu Lys Glu Leu Ser Pro Leu Pro Glu Ser Tyr 
        35                  40                  45              


Leu Ser Asn Lys Arg Asn Val Leu Asn Val Tyr Phe Val Lys Val Ala 
    50                  55                  60                  


Trp Ala Trp Thr Phe Cys Leu Leu Leu Pro Phe Ile Ala Leu Thr Asn 
65                  70                  75                  80  


Tyr His Leu Thr Gly Lys Ala Gly Leu Val Leu Arg Arg Leu Ser Thr 
                85                  90                  95      


Leu Leu Val Gly Thr Ala Ile Trp Tyr Ile Cys Thr Ser Ile Phe Ser 
            100                 105                 110         


Asn Ile Glu His Tyr Thr Gly Ser Cys Tyr Gln Ser Pro Ala Leu Glu 
        115                 120                 125             


Gly Val Arg Lys Glu His Gln Ser Lys Gln Gln Cys His Gln Glu Gly 
    130                 135                 140                 


Gly Phe Trp His Gly Phe Asp Ile Ser Gly His Ser Phe Leu Leu Thr 
145                 150                 155                 160 


Phe Cys Ala Leu Met Ile Val Glu Glu Met Ser Val Leu His Glu Val 
                165                 170                 175     


Lys Thr Asp Arg Ser His Cys Leu His Thr Ala Ile Thr Thr Leu Val 
            180                 185                 190         


Val Ala Leu Gly Ile Leu Thr Phe Ile Trp Val Leu Met Phe Leu Cys 
        195                 200                 205             


Thr Ala Val Tyr Phe His Asn Leu Ser Gln Lys Val Phe Gly Thr Leu 
    210                 215                 220                 


Phe Gly Leu Leu Ser Trp Tyr Gly Thr Tyr Gly Phe Trp Tyr Pro Lys 
225                 230                 235                 240 


Ala Phe Ser Pro Gly Leu Pro Pro Gln Ser Cys Ser Leu Asn Leu Lys 
                245                 250                 255     


Gln Asp Ser Tyr Lys Lys 
            260         


<210>  4065
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FJX1__Homo_sapiens__NP_055159

<400>  4065

Met Gly Arg Arg Met Arg Gly Ala Ala Ala Thr Ala Gly Leu Trp Leu 
1               5                   10                  15      


Leu Ala Leu Gly Ser Leu Leu Ala Leu Trp Gly Gly Leu Leu Pro Pro 
            20                  25                  30          


Arg Thr Glu Leu Pro Ala Ser Arg Pro Pro Glu Asp Arg Leu Pro Arg 
        35                  40                  45              


Arg Pro Ala Arg Ser Gly Gly Pro Ala Pro Ala Pro Arg Phe Pro Leu 
    50                  55                  60                  


Pro Pro Pro Leu Ala Trp Asp Ala Arg Gly Gly Ser Leu Lys Thr Phe 
65                  70                  75                  80  


Arg Ala Leu Leu Thr Leu Ala Ala Gly Ala Asp Gly Pro Pro Arg Gln 
                85                  90                  95      


Ser Arg Ser Glu Pro Arg Trp His Val Ser Ala Arg Gln Pro Arg Pro 
            100                 105                 110         


Glu Glu Ser Ala Ala Val His Gly Gly Val Phe Trp Ser Arg Gly Leu 
        115                 120                 125             


Glu Glu Gln Val Pro Pro Gly Phe Ser Glu Ala Gln Ala Ala Ala Trp 
    130                 135                 140                 


Leu Glu Ala Ala Arg Gly Ala Arg Met Val Ala Leu Glu Arg Gly Gly 
145                 150                 155                 160 


Cys Gly Arg Ser Ser Asn Arg Leu Ala Arg Phe Ala Asp Gly Thr Arg 
                165                 170                 175     


Ala Cys Val Arg Tyr Gly Ile Asn Pro Glu Gln Ile Gln Gly Glu Ala 
            180                 185                 190         


Leu Ser Tyr Tyr Leu Ala Arg Leu Leu Gly Leu Gln Arg His Val Pro 
        195                 200                 205             


Pro Leu Ala Leu Ala Arg Val Glu Ala Arg Gly Ala Gln Trp Ala Gln 
    210                 215                 220                 


Val Gln Glu Glu Leu Arg Ala Ala His Trp Thr Glu Gly Ser Val Val 
225                 230                 235                 240 


Ser Leu Thr Arg Trp Leu Pro Asn Leu Thr Asp Val Val Val Pro Ala 
                245                 250                 255     


Pro Trp Arg Ser Glu Asp Gly Arg Leu Arg Pro Leu Arg Asp Ala Gly 
            260                 265                 270         


Gly Glu Leu Ala Asn Leu Ser Gln Ala Glu Leu Val Asp Leu Val Gln 
        275                 280                 285             


Trp Thr Asp Leu Ile Leu Phe Asp Tyr Leu Thr Ala Asn Phe Asp Arg 
    290                 295                 300                 


Leu Val Ser Asn Leu Phe Ser Leu Gln Trp Asp Pro Arg Val Met Gln 
305                 310                 315                 320 


Arg Ala Thr Ser Asn Leu His Arg Gly Pro Gly Gly Ala Leu Val Phe 
                325                 330                 335     


Leu Asp Asn Glu Ala Gly Leu Val His Gly Tyr Arg Val Ala Gly Met 
            340                 345                 350         


Trp Asp Lys Tyr Asn Glu Pro Leu Leu Gln Ser Val Cys Val Phe Arg 
        355                 360                 365             


Glu Arg Thr Ala Arg Arg Val Leu Glu Leu His Arg Gly Gln Asp Ala 
    370                 375                 380                 


Ala Ala Arg Leu Leu Arg Leu Tyr Arg Arg His Glu Pro Arg Phe Pro 
385                 390                 395                 400 


Glu Leu Ala Ala Leu Ala Asp Pro His Ala Gln Leu Leu Gln Arg Arg 
                405                 410                 415     


Leu Asp Phe Leu Ala Lys His Ile Leu His Cys Lys Ala Lys Tyr Gly 
            420                 425                 430         


Arg Arg Ser Gly Thr 
        435         


<210>  4066
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP10__Homo_sapiens__NP_068758

<400>  4066

Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly 
            20                  25                  30          


Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg 
        35                  40                  45              


Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe 
    50                  55                  60                  


Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp 
65                  70                  75                  80  


Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly 
                85                  90                  95      


Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn 
            100                 105                 110         


Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile 
        115                 120                 125             


Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val 
    130                 135                 140                 


Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr 
145                 150                 155                 160 


Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln Asp Gly Asp Phe 
                165                 170                 175     


Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp 
            180                 185                 190         


Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr Val Gly Ser Gly 
        195                 200                 205             


Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly Met Cys Pro Gly 
    210                 215                 220                 


Glu Arg Arg Lys Ile Ile Ile Pro Pro Phe Leu Ala Tyr Gly Glu Lys 
225                 230                 235                 240 


Gly Tyr Gly Thr Val Ile Pro Pro Gln Ala Ser Leu Val Phe His Val 
                245                 250                 255     


Leu Leu Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr 
            260                 265                 270         


Leu Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe 
        275                 280                 285             


Met Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp 
    290                 295                 300                 


Ser Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly 
305                 310                 315                 320 


Tyr Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly 
                325                 330                 335     


Glu Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn 
            340                 345                 350         


Gly Thr Gly Asp Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val 
        355                 360                 365             


His Val Ile Asp Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr 
    370                 375                 380                 


Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp 
385                 390                 395                 400 


Phe Val Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu 
                405                 410                 415     


Phe Thr Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala 
            420                 425                 430         


Asn Lys Val Ile Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val 
        435                 440                 445             


Gly Glu Arg Arg Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu 
    450                 455                 460                 


Ser Gly Ala Arg Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val 
465                 470                 475                 480 


Glu Leu Val Ser Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val 
                485                 490                 495     


Trp His Lys Asp Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn 
            500                 505                 510         


Lys Asp Gly Glu Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala 
        515                 520                 525             


Gln Val Ser Glu Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu 
    530                 535                 540                 


Lys Thr Ile Gly Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly 
545                 550                 555                 560 


Lys Ile Thr Val Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu 
                565                 570                 575     


Arg Val His Glu Glu Leu 
            580         


<210>  4067
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP11__Homo_sapiens__NP_001137253

<400>  4067

Met Cys Val Gly Glu Lys Arg Arg Ala Ile Ile Pro Ser His Leu Ala 
1               5                   10                  15      


Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val Pro Ala Asp Ala Val Val 
            20                  25                  30          


Gln Tyr Asp Val Glu Leu Ile Ala Leu Ile Arg Ala Asn Tyr Trp Leu 
        35                  40                  45              


Lys Leu Val Lys Gly Ile Leu Pro Leu Val Gly Met Ala Met Val Pro 
    50                  55                  60                  


Ala Leu Leu Gly Leu Ile Gly Tyr His Leu Tyr Arg Lys Ala Asn Arg 
65                  70                  75                  80  


Pro Lys Val Ser Lys Lys Lys Leu Lys Glu Glu Lys Arg Asn Lys Ser 
                85                  90                  95      


Lys Lys Lys 
            


<210>  4068
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP14__Homo_sapiens__NP_060416

<400>  4068

Met Arg Leu Phe Leu Trp Asn Ala Val Leu Thr Leu Phe Val Thr Ser 
1               5                   10                  15      


Leu Ile Gly Ala Leu Ile Pro Glu Pro Glu Val Lys Ile Glu Val Leu 
            20                  25                  30          


Gln Lys Pro Phe Ile Cys His Arg Lys Thr Lys Gly Gly Asp Leu Met 
        35                  40                  45              


Leu Val His Tyr Glu Gly Tyr Leu Glu Lys Asp Gly Ser Leu Phe His 
    50                  55                  60                  


Ser Thr His Lys His Asn Asn Gly Gln Pro Ile Trp Phe Thr Leu Gly 
65                  70                  75                  80  


Ile Leu Glu Ala Leu Lys Gly Trp Asp Gln Gly Leu Lys Gly Met Cys 
                85                  90                  95      


Val Gly Glu Lys Arg Lys Leu Ile Ile Pro Pro Ala Leu Gly Tyr Gly 
            100                 105                 110         


Lys Glu Gly Lys Gly Lys Ile Pro Pro Glu Ser Thr Leu Ile Phe Asn 
        115                 120                 125             


Ile Asp Leu Leu Glu Ile Arg Asn Gly Pro Arg Ser His Glu Ser Phe 
    130                 135                 140                 


Gln Glu Met Asp Leu Asn Asp Asp Trp Lys Leu Ser Lys Asp Glu Val 
145                 150                 155                 160 


Lys Ala Tyr Leu Lys Lys Glu Phe Glu Lys His Gly Ala Val Val Asn 
                165                 170                 175     


Glu Ser His His Asp Ala Leu Val Glu Asp Ile Phe Asp Lys Glu Asp 
            180                 185                 190         


Glu Asp Lys Asp Gly Phe Ile Ser Ala Arg Glu Phe Thr Tyr Lys His 
        195                 200                 205             


Asp Glu Leu 
    210     


<210>  4069
<211>  1219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP15__Homo_sapiens__NP_056073

<400>  4069

Met Phe Gly Ala Gly Asp Glu Asp Asp Thr Asp Phe Leu Ser Pro Ser 
1               5                   10                  15      


Gly Gly Ala Arg Leu Ala Ser Leu Phe Gly Leu Asp Gln Ala Ala Ala 
            20                  25                  30          


Gly His Gly Asn Glu Phe Phe Gln Tyr Thr Ala Pro Lys Gln Pro Lys 
        35                  40                  45              


Lys Gly Gln Gly Thr Ala Ala Thr Gly Asn Gln Ala Thr Pro Lys Thr 
    50                  55                  60                  


Ala Pro Ala Thr Met Ser Thr Pro Thr Ile Leu Val Ala Thr Ala Val 
65                  70                  75                  80  


His Ala Tyr Arg Tyr Thr Asn Gly Gln Tyr Val Lys Gln Gly Lys Phe 
                85                  90                  95      


Gly Ala Ala Val Leu Gly Asn His Thr Ala Arg Glu Tyr Arg Ile Leu 
            100                 105                 110         


Leu Tyr Ile Ser Gln Gln Gln Pro Val Thr Val Ala Arg Ile His Val 
        115                 120                 125             


Asn Phe Glu Leu Met Val Arg Pro Asn Asn Tyr Ser Thr Phe Tyr Asp 
    130                 135                 140                 


Asp Gln Arg Gln Asn Trp Ser Ile Met Phe Glu Ser Glu Lys Ala Ala 
145                 150                 155                 160 


Val Glu Phe Asn Lys Gln Val Cys Ile Ala Lys Cys Asn Ser Thr Ser 
                165                 170                 175     


Ser Leu Asp Ala Val Leu Ser Gln Asp Leu Ile Val Ala Asp Gly Pro 
            180                 185                 190         


Ala Val Glu Val Gly Asp Ser Leu Glu Val Ala Tyr Thr Gly Trp Leu 
        195                 200                 205             


Phe Gln Asn His Val Leu Gly Gln Val Phe Asp Ser Thr Ala Asn Lys 
    210                 215                 220                 


Asp Lys Leu Leu Arg Leu Lys Leu Gly Ser Gly Lys Val Ile Lys Gly 
225                 230                 235                 240 


Trp Glu Asp Gly Met Leu Gly Met Lys Lys Gly Gly Lys Arg Leu Leu 
                245                 250                 255     


Ile Val Pro Pro Ala Cys Ala Val Gly Ser Glu Gly Val Ile Gly Trp 
            260                 265                 270         


Thr Gln Ala Thr Asp Ser Ile Leu Val Phe Glu Val Glu Val Arg Arg 
        275                 280                 285             


Val Lys Phe Ala Arg Asp Ser Gly Ser Asp Gly His Ser Val Ser Ser 
    290                 295                 300                 


Arg Asp Ser Ala Ala Pro Ser Pro Ile Pro Gly Ala Asp Asn Leu Ser 
305                 310                 315                 320 


Ala Asp Pro Val Val Ser Pro Pro Thr Ser Ile Pro Phe Lys Ser Gly 
                325                 330                 335     


Glu Pro Ala Leu Arg Thr Lys Ser Asn Ser Leu Ser Glu Gln Leu Ala 
            340                 345                 350         


Ile Asn Thr Ser Pro Asp Ala Val Lys Ala Lys Leu Ile Ser Arg Met 
        355                 360                 365             


Ala Lys Met Gly Gln Pro Met Leu Pro Ile Leu Pro Pro Gln Leu Asp 
    370                 375                 380                 


Ser Asn Asp Ser Glu Ile Glu Asp Val Asn Thr Leu Gln Gly Gly Gly 
385                 390                 395                 400 


Gln Pro Val Val Thr Pro Ser Val Gln Pro Ser Leu His Pro Ala His 
                405                 410                 415     


Pro Ala Leu Pro Gln Met Thr Ser Gln Ala Pro Gln Pro Ser Val Thr 
            420                 425                 430         


Gly Leu Gln Ala Pro Ser Ala Ala Leu Met Gln Val Ser Ser Leu Asp 
        435                 440                 445             


Ser His Ser Ala Val Ser Gly Asn Ala Gln Ser Phe Gln Pro Tyr Ala 
    450                 455                 460                 


Gly Met Gln Ala Tyr Ala Tyr Pro Gln Ala Ser Ala Val Thr Ser Gln 
465                 470                 475                 480 


Leu Gln Pro Val Arg Pro Leu Tyr Pro Ala Pro Leu Ser Gln Pro Pro 
                485                 490                 495     


His Phe Gln Gly Ser Gly Asp Met Ala Ser Phe Leu Met Thr Glu Ala 
            500                 505                 510         


Arg Gln His Asn Thr Glu Ile Arg Met Ala Val Ser Lys Val Ala Asp 
        515                 520                 525             


Lys Met Asp His Leu Met Thr Lys Val Glu Glu Leu Gln Lys His Ser 
    530                 535                 540                 


Ala Gly Asn Ser Met Leu Ile Pro Ser Met Ser Val Thr Met Glu Thr 
545                 550                 555                 560 


Ser Met Ile Met Ser Asn Ile Gln Arg Ile Ile Gln Glu Asn Glu Arg 
                565                 570                 575     


Leu Lys Gln Glu Ile Leu Glu Lys Ser Asn Arg Ile Glu Glu Gln Asn 
            580                 585                 590         


Asp Lys Ile Ser Glu Leu Ile Glu Arg Asn Gln Arg Tyr Val Glu Gln 
        595                 600                 605             


Ser Asn Leu Met Met Glu Lys Arg Asn Asn Ser Leu Gln Thr Ala Thr 
    610                 615                 620                 


Glu Asn Thr Gln Ala Arg Val Leu His Ala Glu Gln Glu Lys Ala Lys 
625                 630                 635                 640 


Val Thr Glu Glu Leu Ala Ala Ala Thr Ala Gln Val Ser His Leu Gln 
                645                 650                 655     


Leu Lys Met Thr Ala His Gln Lys Lys Glu Thr Glu Leu Gln Met Gln 
            660                 665                 670         


Leu Thr Glu Ser Leu Lys Glu Thr Asp Leu Leu Arg Gly Gln Leu Thr 
        675                 680                 685             


Lys Val Gln Ala Lys Leu Ser Glu Leu Gln Glu Thr Ser Glu Gln Ala 
    690                 695                 700                 


Gln Ser Lys Phe Lys Ser Glu Lys Gln Asn Arg Lys Gln Leu Glu Leu 
705                 710                 715                 720 


Lys Val Thr Ser Leu Glu Glu Glu Leu Thr Asp Leu Arg Val Glu Lys 
                725                 730                 735     


Glu Ser Leu Glu Lys Asn Leu Ser Glu Arg Lys Lys Lys Ser Ala Gln 
            740                 745                 750         


Glu Arg Ser Gln Ala Glu Glu Glu Ile Asp Glu Ile Arg Lys Ser Tyr 
        755                 760                 765             


Gln Glu Glu Leu Asp Lys Leu Arg Gln Leu Leu Lys Lys Thr Arg Val 
    770                 775                 780                 


Ser Thr Asp Gln Ala Ala Ala Glu Gln Leu Ser Leu Val Gln Ala Glu 
785                 790                 795                 800 


Leu Gln Thr Gln Trp Glu Ala Lys Cys Glu His Leu Leu Ala Ser Ala 
                805                 810                 815     


Lys Asp Glu His Leu Gln Gln Tyr Gln Glu Val Cys Ala Gln Arg Asp 
            820                 825                 830         


Ala Tyr Gln Gln Lys Leu Val Gln Leu Gln Glu Lys Cys Leu Ala Leu 
        835                 840                 845             


Gln Ala Gln Ile Thr Ala Leu Thr Lys Gln Asn Glu Gln His Ile Lys 
    850                 855                 860                 


Glu Leu Glu Lys Asn Lys Ser Gln Met Ser Gly Val Glu Ala Ala Ala 
865                 870                 875                 880 


Ser Asp Pro Ser Glu Lys Val Lys Lys Ile Met Asn Gln Val Phe Gln 
                885                 890                 895     


Ser Leu Arg Arg Glu Phe Glu Leu Glu Glu Ser Tyr Asn Gly Arg Thr 
            900                 905                 910         


Ile Leu Gly Thr Ile Met Asn Thr Ile Lys Met Val Thr Leu Gln Leu 
        915                 920                 925             


Leu Asn Gln Gln Glu Gln Glu Lys Glu Glu Ser Ser Ser Glu Glu Glu 
    930                 935                 940                 


Glu Glu Lys Ala Glu Glu Arg Pro Arg Arg Pro Ser Gln Glu Gln Ser 
945                 950                 955                 960 


Ala Ser Ala Ser Ser Gly Gln Pro Gln Ala Pro Leu Asn Arg Glu Arg 
                965                 970                 975     


Pro Glu Ser Pro Met Val Pro Ser Glu Gln Val Val Glu Glu Ala Val 
            980                 985                 990         


Pro Leu Pro Pro Gln Ala Leu Thr  Thr Ser Gln Asp Gly  His Arg Arg 
        995                 1000                 1005             


Lys Gly  Asp Ser Glu Ala Glu  Ala Leu Ser Glu Ile  Lys Asp Gly 
    1010                 1015                 1020             


Ser Leu  Pro Pro Glu Leu Ser  Cys Ile Pro Ser His  Arg Val Leu 
    1025                 1030                 1035             


Gly Pro  Pro Thr Ser Ile Pro  Pro Glu Pro Leu Gly  Pro Val Ser 
    1040                 1045                 1050             


Met Asp  Ser Glu Cys Glu Glu  Ser Leu Ala Ala Ser  Pro Met Ala 
    1055                 1060                 1065             


Ala Lys  Pro Asp Asn Pro Ser  Gly Lys Val Cys Val  Arg Glu Val 
    1070                 1075                 1080             


Ala Pro  Asp Gly Pro Leu Gln  Glu Ser Ser Thr Arg  Leu Ser Leu 
    1085                 1090                 1095             


Thr Ser  Asp Pro Glu Glu Gly  Asp Pro Leu Ala Leu  Gly Pro Glu 
    1100                 1105                 1110             


Ser Pro  Gly Glu Pro Gln Pro  Pro Gln Leu Lys Lys  Asp Asp Val 
    1115                 1120                 1125             


Thr Ser  Ser Thr Gly Pro His  Lys Glu Leu Ser Ser  Thr Glu Ala 
    1130                 1135                 1140             


Gly Ser  Thr Val Ala Gly Ala  Ala Leu Arg Pro Ser  His His Ser 
    1145                 1150                 1155             


Gln Arg  Ser Ser Leu Ser Gly  Asp Glu Glu Asp Glu  Leu Phe Lys 
    1160                 1165                 1170             


Gly Ala  Thr Leu Lys Ala Leu  Arg Pro Lys Ala Gln  Pro Glu Glu 
    1175                 1180                 1185             


Glu Asp  Glu Asp Glu Val Ser  Met Lys Gly Arg Pro  Pro Pro Thr 
    1190                 1195                 1200             


Pro Leu  Phe Gly Asp Asp Asp  Asp Asp Asp Asp Ile  Asp Trp Leu 
    1205                 1210                 1215             


Gly 
    


<210>  4070
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP1A__Homo_sapiens__NP_000792

<400>  4070

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  4071
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP1B__Homo_sapiens__NP_004107

<400>  4071

Met Gly Val Glu Ile Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Lys Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gln 
            20                  25                  30          


Asn Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Arg Ile Gly Lys Gln Glu Val Ile Lys Gly Phe Glu Glu Gly Ala 
    50                  55                  60                  


Ala Gln Met Ser Leu Gly Gln Arg Ala Lys Leu Thr Cys Thr Pro Asp 
65                  70                  75                  80  


Val Ala Tyr Gly Ala Thr Gly His Pro Gly Val Ile Pro Pro Asn Ala 
                85                  90                  95      


Thr Leu Ile Phe Asp Val Glu Leu Leu Asn Leu Glu 
            100                 105             


<210>  4072
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP2__Homo_sapiens__NP_004461

<400>  4072

Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu Ser Ile Cys Leu 
1               5                   10                  15      


Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys Arg Lys Leu Gln 
            20                  25                  30          


Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile Lys Ser Arg Lys 
        35                  40                  45              


Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu Glu Asp Gly Thr 
    50                  55                  60                  


Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe Val Phe Ser Leu 
65                  70                  75                  80  


Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly Leu Leu Gly Met 
                85                  90                  95      


Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser Glu Leu Gly Tyr 
            100                 105                 110         


Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly Ala Thr Leu Val 
        115                 120                 125             


Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr Glu Leu 
    130                 135                 140         


<210>  4073
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP3__Homo_sapiens__NP_002004

<400>  4073

Met Ala Ala Ala Val Pro Gln Arg Ala Trp Thr Val Glu Gln Leu Arg 
1               5                   10                  15      


Ser Glu Gln Leu Pro Lys Lys Asp Ile Ile Lys Phe Leu Gln Glu His 
            20                  25                  30          


Gly Ser Asp Ser Phe Leu Ala Glu His Lys Leu Leu Gly Asn Ile Lys 
        35                  40                  45              


Asn Val Ala Lys Thr Ala Asn Lys Asp His Leu Val Thr Ala Tyr Asn 
    50                  55                  60                  


His Leu Phe Glu Thr Lys Arg Phe Lys Gly Thr Glu Ser Ile Ser Lys 
65                  70                  75                  80  


Val Ser Glu Gln Val Lys Asn Val Lys Leu Asn Glu Asp Lys Pro Lys 
                85                  90                  95      


Glu Thr Lys Ser Glu Glu Thr Leu Asp Glu Gly Pro Pro Lys Tyr Thr 
            100                 105                 110         


Lys Ser Val Leu Lys Lys Gly Asp Lys Thr Asn Phe Pro Lys Lys Gly 
        115                 120                 125             


Asp Val Val His Cys Trp Tyr Thr Gly Thr Leu Gln Asp Gly Thr Val 
    130                 135                 140                 


Phe Asp Thr Asn Ile Gln Thr Ser Ala Lys Lys Lys Lys Asn Ala Lys 
145                 150                 155                 160 


Pro Leu Ser Phe Lys Val Gly Val Gly Lys Val Ile Arg Gly Trp Asp 
                165                 170                 175     


Glu Ala Leu Leu Thr Met Ser Lys Gly Glu Lys Ala Arg Leu Glu Ile 
            180                 185                 190         


Glu Pro Glu Trp Ala Tyr Gly Lys Lys Gly Gln Pro Asp Ala Lys Ile 
        195                 200                 205             


Pro Pro Asn Ala Lys Leu Thr Phe Glu Val Glu Leu Val Asp Ile Asp 
    210                 215                 220                 


<210>  4074
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP4__Homo_sapiens__NP_002005

<400>  4074

Met Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala 
1               5                   10                  15      


Pro Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly 
            20                  25                  30          


Val Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met 
        35                  40                  45              


Ile Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly 
    50                  55                  60                  


Thr Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp 
65                  70                  75                  80  


Leu Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr 
                85                  90                  95      


Met Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala 
            100                 105                 110         


Tyr Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu 
        115                 120                 125             


Val Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu 
    130                 135                 140                 


Glu Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly 
145                 150                 155                 160 


Tyr Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly 
                165                 170                 175     


Tyr Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile 
            180                 185                 190         


Gly Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile 
        195                 200                 205             


Gln Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser 
    210                 215                 220                 


Tyr Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn 
225                 230                 235                 240 


Ala Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys 
                245                 250                 255     


Glu Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile 
            260                 265                 270         


Val Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln 
        275                 280                 285             


Ala Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser 
    290                 295                 300                 


Ser Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala 
305                 310                 315                 320 


Ser His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser 
                325                 330                 335     


Ala Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn 
            340                 345                 350         


Glu Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp 
        355                 360                 365             


Phe Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro 
    370                 375                 380                 


Asn Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile 
385                 390                 395                 400 


Arg Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu 
                405                 410                 415     


Arg Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly 
            420                 425                 430         


Asp His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr 
        435                 440                 445             


Ala Gly Ser Gln Ser Gln Val Glu Thr Glu Ala 
    450                 455                 


<210>  4075
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP5__Homo_sapiens__NP_001139247

<400>  4075

Met Thr Thr Asp Glu Gly Ala Lys Asn Asn Glu Glu Ser Pro Thr Ala 
1               5                   10                  15      


Thr Val Ala Glu Gln Gly Glu Asp Ile Thr Ser Lys Lys Asp Arg Gly 
            20                  25                  30          


Val Leu Lys Ile Val Lys Arg Val Gly Asn Gly Glu Glu Thr Pro Met 
        35                  40                  45              


Ile Gly Asp Lys Val Tyr Val His Tyr Lys Gly Lys Leu Ser Asn Gly 
    50                  55                  60                  


Lys Lys Phe Asp Ser Ser His Asp Arg Asn Glu Pro Phe Val Phe Ser 
65                  70                  75                  80  


Leu Gly Lys Gly Gln Val Ile Lys Ala Trp Asp Ile Gly Val Ala Thr 
                85                  90                  95      


Met Lys Lys Gly Glu Ile Cys His Leu Leu Cys Lys Pro Glu Tyr Ala 
            100                 105                 110         


Tyr Gly Ser Ala Gly Ser Leu Pro Lys Ile Pro Ser Asn Ala Thr Leu 
        115                 120                 125             


Phe Phe Glu Ile Glu Leu Leu Asp Phe Lys Gly Glu Asp Leu Phe Glu 
    130                 135                 140                 


Asp Gly Gly Ile Ile Arg Arg Thr Lys Arg Lys Gly Glu Gly Tyr Ser 
145                 150                 155                 160 


Asn Pro Asn Glu Gly Ala Thr Val Glu Ile His Leu Glu Gly Arg Cys 
                165                 170                 175     


Gly Gly Arg Met Phe Asp Cys Arg Asp Val Ala Phe Thr Val Gly Glu 
            180                 185                 190         


Gly Glu Asp His Asp Ile Pro Ile Gly Ile Asp Lys Ala Leu Glu Lys 
        195                 200                 205             


Met Gln Arg Glu Glu Gln Cys Ile Leu Tyr Leu Gly Pro Arg Tyr Gly 
    210                 215                 220                 


Phe Gly Glu Ala Gly Lys Pro Lys Phe Gly Ile Glu Pro Asn Ala Glu 
225                 230                 235                 240 


Leu Ile Tyr Glu Val Thr Leu Lys Ser Phe Glu Lys Ala Lys Glu Ser 
                245                 250                 255     


Trp Glu Met Asp Thr Lys Glu Lys Leu Glu Gln Ala Ala Ile Val Lys 
            260                 265                 270         


Glu Lys Gly Thr Val Tyr Phe Lys Gly Gly Lys Tyr Met Gln Ala Val 
        275                 280                 285             


Ile Gln Tyr Gly Lys Ile Val Ser Trp Leu Glu Met Glu Tyr Gly Leu 
    290                 295                 300                 


Ser Glu Lys Glu Ser Lys Ala Ser Glu Ser Phe Leu Leu Ala Ala Phe 
305                 310                 315                 320 


Leu Asn Leu Ala Met Cys Tyr Leu Lys Leu Arg Glu Tyr Thr Lys Ala 
                325                 330                 335     


Val Glu Cys Cys Asp Lys Ala Leu Gly Leu Asp Ser Ala Asn Glu Lys 
            340                 345                 350         


Gly Leu Tyr Arg Arg Gly Glu Ala Gln Leu Leu Met Asn Glu Phe Glu 
        355                 360                 365             


Ser Ala Lys Gly Asp Phe Glu Lys Val Leu Glu Val Asn Pro Gln Asn 
    370                 375                 380                 


Lys Ala Ala Arg Leu Gln Ile Ser Met Cys Gln Lys Lys Ala Lys Glu 
385                 390                 395                 400 


His Asn Glu Arg Asp Arg Arg Ile Tyr Ala Asn Met Phe Lys Lys Phe 
                405                 410                 415     


Ala Glu Gln Asp Ala Lys Glu Glu Ala Asn Lys Ala Met Gly Lys Lys 
            420                 425                 430         


Thr Ser Glu Gly Val Thr Asn Glu Lys Gly Thr Asp Ser Gln Ala Met 
        435                 440                 445             


Glu Glu Glu Lys Pro Glu Gly His Val 
    450                 455         


<210>  4076
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP6__Homo_sapiens__NP_001128683

<400>  4076

Met Ser Ala Ser Ser Trp Pro Gln Asn Gly Met Pro Pro Ser Ser Leu 
1               5                   10                  15      


Tyr Glu Arg Leu Ser Gln Arg Met Leu Asp Ile Ser Gly Asp Arg Gly 
            20                  25                  30          


Val Leu Lys Asp Val Ile Arg Glu Gly Ala Gly Asp Leu Val Ala Pro 
        35                  40                  45              


Asp Ala Ser Val Leu Val Lys Tyr Ser Gly Tyr Leu Glu His Met Asp 
    50                  55                  60                  


Arg Pro Phe Asp Ser Asn Tyr Phe Arg Lys Thr Pro Arg Leu Met Lys 
65                  70                  75                  80  


Leu Gly Glu Asp Ile Thr Leu Trp Gly Met Glu Leu Gly Leu Leu Ser 
                85                  90                  95      


Met Arg Arg Gly Glu Leu Ala Arg Phe Leu Phe Lys Pro Asn Tyr Ala 
            100                 105                 110         


Tyr Gly Thr Leu Gly Cys Pro Pro Leu Ile Pro Pro Asn Thr Thr Val 
        115                 120                 125             


Leu Phe Glu Ile Glu Leu Leu Asp Phe Leu Asp Cys Ala Glu Ser Asp 
    130                 135                 140                 


Lys Phe Cys Ala Leu Ser Ala Glu Gln Gln Asp Gln Phe Pro Leu Gln 
145                 150                 155                 160 


Lys Val Leu Lys Val Ala Ala Thr Glu Arg Glu Phe Gly Asn Tyr Leu 
                165                 170                 175     


Phe Arg Gln Asn Arg Phe Tyr Asp Ala Lys Val Arg Tyr Lys Arg Ala 
            180                 185                 190         


Leu Leu Leu Leu Arg Arg Arg Ser Ala Pro Pro Glu Glu Gln His Leu 
        195                 200                 205             


Val Glu Ala Ala Lys Leu Pro Val Leu Leu Asn Leu Ser Phe Thr Tyr 
    210                 215                 220                 


Leu Lys Leu Asp Arg Pro Thr Ile Ala Leu Cys Tyr Gly Glu Gln Ala 
225                 230                 235                 240 


Leu Ile Ile Asp Gln Lys Asn Ala Lys Ala Leu Phe Arg Cys Gly Gln 
                245                 250                 255     


Ala Cys Leu Leu Leu Thr Glu Tyr Gln Lys Ala Arg Asp Phe Leu Val 
            260                 265                 270         


Arg Ala Gln Lys Glu Gln Pro Phe Asn His Asp Ile Asn Asn Glu Leu 
        275                 280                 285             


Lys Lys Leu Ala Ser Cys Tyr Arg Asp Tyr Val Asp Lys Glu Lys Glu 
    290                 295                 300                 


Met Trp His Arg Met Phe Ala Pro Cys Gly Asp Gly Ser Thr Ala Gly 
305                 310                 315                 320 


Glu Ser 
        


<210>  4077
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP7__Homo_sapiens__NP_001128684

<400>  4077

Met Pro Lys Thr Met His Phe Leu Phe Arg Phe Ile Val Phe Phe Tyr 
1               5                   10                  15      


Leu Trp Gly Leu Phe Thr Ala Gln Arg Gln Lys Lys Glu Glu Ser Thr 
            20                  25                  30          


Glu Glu Val Lys Ile Glu Val Leu His Arg Pro Glu Asn Cys Ser Lys 
        35                  40                  45              


Thr Ser Lys Lys Gly Asp Leu Leu Asn Ala His Tyr Asp Gly Tyr Leu 
    50                  55                  60                  


Ala Lys Asp Gly Ser Lys Phe Tyr Cys Ser Arg Thr Gln Asn Glu Gly 
65                  70                  75                  80  


His Pro Lys Trp Phe Val Leu Gly Val Gly Gln Val Ile Lys Gly Leu 
                85                  90                  95      


Asp Ile Ala Met Thr Asp Met Cys Pro Gly Glu Lys Arg Lys Val Val 
            100                 105                 110         


Ile Pro Pro Ser Phe Ala Tyr Gly Lys Glu Gly Tyr Glu Gly Lys Ile 
        115                 120                 125             


Pro Pro Asp Ala Thr Leu Ile Phe Glu Ile Glu Leu Tyr Ala Val Thr 
    130                 135                 140                 


Lys Gly Pro Arg Ser Ile Glu Thr Phe Lys Gln Ile Asp Met Asp Asn 
145                 150                 155                 160 


Asp Arg Gln Leu Ser Lys Ala Glu Ile Asn Leu Tyr Leu Gln Arg Glu 
                165                 170                 175     


Phe Glu Lys Asp Glu Lys Pro Arg Asp Lys Ser Tyr Gln Asp Ala Val 
            180                 185                 190         


Leu Glu Asp Ile Phe Lys Lys Asn Asp His Asp Gly Asp Gly Phe Ile 
        195                 200                 205             


Ser Pro Lys Glu Tyr Asn Val Tyr Gln His Asp Glu Leu 
    210                 215                 220     


<210>  4078
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP8__Homo_sapiens__NP_036313

<400>  4078

Met Ala Ser Cys Ala Glu Pro Ser Glu Pro Ser Ala Pro Leu Pro Ala 
1               5                   10                  15      


Gly Val Pro Pro Leu Glu Asp Phe Glu Val Leu Asp Gly Val Glu Asp 
            20                  25                  30          


Ala Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp 
        35                  40                  45              


Leu Ser Glu Leu Pro Pro Leu Glu Asp Met Gly Gln Pro Pro Ala Glu 
    50                  55                  60                  


Glu Ala Glu Gln Pro Gly Ala Leu Ala Arg Glu Phe Leu Ala Ala Met 
65                  70                  75                  80  


Glu Pro Glu Pro Ala Pro Ala Pro Ala Pro Glu Glu Trp Leu Asp Ile 
                85                  90                  95      


Leu Gly Asn Gly Leu Leu Arg Lys Lys Thr Leu Val Pro Gly Pro Pro 
            100                 105                 110         


Gly Ser Ser Arg Pro Val Lys Gly Gln Val Val Thr Val His Leu Gln 
        115                 120                 125             


Thr Ser Leu Glu Asn Gly Thr Arg Val Gln Glu Glu Pro Glu Leu Val 
    130                 135                 140                 


Phe Thr Leu Gly Asp Cys Asp Val Ile Gln Ala Leu Asp Leu Ser Val 
145                 150                 155                 160 


Pro Leu Met Asp Val Gly Glu Thr Ala Met Val Thr Ala Asp Ser Lys 
                165                 170                 175     


Tyr Cys Tyr Gly Pro Gln Gly Ser Arg Ser Pro Tyr Ile Pro Pro His 
            180                 185                 190         


Ala Ala Leu Cys Leu Glu Val Thr Leu Lys Thr Ala Val Asp Gly Pro 
        195                 200                 205             


Asp Leu Glu Met Leu Thr Gly Gln Glu Arg Val Ala Leu Ala Asn Arg 
    210                 215                 220                 


Lys Arg Glu Cys Gly Asn Ala His Tyr Gln Arg Ala Asp Phe Val Leu 
225                 230                 235                 240 


Ala Ala Asn Ser Tyr Asp Leu Ala Ile Lys Ala Ile Thr Ser Ser Ala 
                245                 250                 255     


Lys Val Asp Met Thr Phe Glu Glu Glu Ala Gln Leu Leu Gln Leu Lys 
            260                 265                 270         


Val Lys Cys Leu Asn Asn Leu Ala Ala Ser Gln Leu Lys Leu Asp His 
        275                 280                 285             


Tyr Arg Ala Ala Leu Arg Ser Cys Ser Leu Val Leu Glu His Gln Pro 
    290                 295                 300                 


Asp Asn Ile Lys Ala Leu Phe Arg Lys Gly Lys Val Leu Ala Gln Gln 
305                 310                 315                 320 


Gly Glu Tyr Ser Glu Ala Ile Pro Ile Leu Arg Ala Ala Leu Lys Leu 
                325                 330                 335     


Glu Pro Ser Asn Lys Thr Ile His Ala Glu Leu Ser Lys Leu Val Lys 
            340                 345                 350         


Lys His Ala Ala Gln Arg Ser Thr Glu Thr Ala Leu Tyr Arg Lys Met 
        355                 360                 365             


Leu Gly Asn Pro Ser Arg Leu Pro Ala Lys Cys Pro Gly Lys Gly Ala 
    370                 375                 380                 


Trp Ser Ile Pro Trp Lys Trp Leu Phe Gly Ala Thr Ala Val Ala Leu 
385                 390                 395                 400 


Gly Gly Val Ala Leu Ser Val Val Ile Ala Ala Arg Asn 
                405                 410             


<210>  4079
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBP9__Homo_sapiens__NP_001271270

<400>  4079

Met Ala Phe Arg Gly Trp Arg Pro Pro Pro Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Trp Val Thr Gly Gln Ala Ala Pro Val Ala Gly Leu Gly Ser 
            20                  25                  30          


Asp Ala Glu Leu Gln Ile Glu Arg Arg Phe Val Pro Asp Glu Cys Pro 
        35                  40                  45              


Arg Thr Val Arg Ser Gly Asp Phe Val Arg Tyr His Tyr Val Gly Thr 
    50                  55                  60                  


Phe Pro Asp Gly Gln Lys Phe Asp Ser Arg Tyr Trp Asp Thr Ala Glu 
65                  70                  75                  80  


Asp Lys Ala Asp Lys Ser Pro Cys Pro Gln Val Arg Val Gly Val Asn 
                85                  90                  95      


Thr Ser Pro Ser Cys Arg Leu Lys Gln Lys Gly Val Gly Ile Tyr Trp 
            100                 105                 110         


Lys Asp Leu Gln Phe Leu Val Arg Val Gln Asn His Gly Leu Ser Tyr 
        115                 120                 125             


Asp Arg Asp Ser Thr Phe Asn Val Phe Val Gly Lys Gly Gln Leu Ile 
    130                 135                 140                 


Thr Gly Met Asp Gln Ala Leu Val Gly Met Cys Val Asn Glu Arg Arg 
145                 150                 155                 160 


Phe Val Lys Ile Pro Pro Lys Leu Ala Tyr Gly Asn Glu Gly Val Ser 
                165                 170                 175     


Gly Val Ile Pro Pro Asn Ser Val Leu His Phe Asp Val Leu Leu Met 
            180                 185                 190         


Asp Ile Trp Asn Ser Glu Asp Gln Val Gln Ile His Thr Tyr Phe Lys 
        195                 200                 205             


Pro Pro Ser Cys Pro Arg Thr Ile Gln Val Ser Asp Phe Val Arg Tyr 
    210                 215                 220                 


His Tyr Asn Gly Thr Phe Leu Asp Gly Thr Leu Phe Asp Ser Ser His 
225                 230                 235                 240 


Asn Arg Met Lys Thr Tyr Asp Thr Tyr Val Gly Ile Gly Trp Leu Ile 
                245                 250                 255     


Pro Gly Met Asp Lys Gly Leu Leu Gly Met Cys Val Gly Glu Lys Arg 
            260                 265                 270         


Ile Ile Thr Ile Pro Pro Phe Leu Ala Tyr Gly Glu Asp Gly Asp Gly 
        275                 280                 285             


Lys Asp Ile Pro Gly Gln Ala Ser Leu Val Phe Asp Val Ala Leu Leu 
    290                 295                 300                 


Asp Leu His Asn Pro Lys Asp Ser Ile Ser Ile Glu Asn Lys Val Val 
305                 310                 315                 320 


Pro Glu Asn Cys Glu Arg Ile Ser Gln Ser Gly Asp Phe Leu Arg Tyr 
                325                 330                 335     


His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Leu Phe Asp Ser Ser Tyr 
            340                 345                 350         


Ser Arg Asn Arg Thr Phe Asp Thr Tyr Ile Gly Gln Gly Tyr Val Ile 
        355                 360                 365             


Pro Gly Met Asp Glu Gly Leu Leu Gly Val Cys Ile Gly Glu Lys Arg 
    370                 375                 380                 


Arg Ile Val Val Pro Pro His Leu Gly Tyr Gly Glu Glu Gly Arg Gly 
385                 390                 395                 400 


Asn Ile Pro Gly Ser Ala Val Leu Val Phe Asp Ile His Val Ile Asp 
                405                 410                 415     


Phe His Asn Pro Ser Asp Ser Ile Ser Ile Thr Ser His Tyr Lys Pro 
            420                 425                 430         


Pro Asp Cys Ser Val Leu Ser Lys Lys Gly Asp Tyr Leu Lys Tyr His 
        435                 440                 445             


Tyr Asn Ala Ser Leu Leu Asp Gly Thr Leu Leu Asp Ser Thr Trp Asn 
    450                 455                 460                 


Leu Gly Lys Thr Tyr Asn Ile Val Leu Gly Ser Gly Gln Val Val Leu 
465                 470                 475                 480 


Gly Met Asp Met Gly Leu Arg Glu Met Cys Val Gly Glu Lys Arg Thr 
                485                 490                 495     


Val Ile Ile Pro Pro His Leu Gly Tyr Gly Glu Ala Gly Val Asp Gly 
            500                 505                 510         


Glu Val Pro Gly Ser Ala Val Leu Val Phe Asp Ile Glu Leu Leu Glu 
        515                 520                 525             


Leu Val Ala Gly Leu Pro Glu Gly Tyr Met Phe Ile Trp Asn Gly Glu 
    530                 535                 540                 


Val Ser Pro Asn Leu Phe Glu Glu Ile Asp Lys Asp Gly Asn Gly Glu 
545                 550                 555                 560 


Val Leu Leu Glu Glu Phe Ser Glu Tyr Ile His Ala Gln Val Ala Ser 
                565                 570                 575     


Gly Lys Gly Lys Leu Ala Pro Gly Phe Asp Ala Glu Leu Ile Val Lys 
            580                 585                 590         


Asn Met Phe Thr Asn Gln Asp Arg Asn Gly Asp Gly Lys Val Thr Ala 
        595                 600                 605             


Glu Glu Phe Lys Leu Lys Asp Gln Glu Ala Lys His Asp Glu Leu 
    610                 615                 620             


<210>  4080
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKBPL__Homo_sapiens__NP_071393

<400>  4080

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp Gly Glu Leu Ile 
145                 150                 155                 160 


Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu Ala Glu Leu Gln 
                165                 170                 175     


Leu Pro Gly His Ser Gly Pro Pro Val Arg Leu Thr Leu Ala Ser Phe 
            180                 185                 190         


Thr Gln Gly Arg Asp Ser Trp Glu Leu Glu Thr Ser Glu Lys Glu Ala 
        195                 200                 205             


Leu Ala Arg Glu Glu Arg Ala Arg Gly Thr Glu Leu Phe Arg Ala Gly 
    210                 215                 220                 


Asn Pro Glu Gly Ala Ala Arg Cys Tyr Gly Arg Ala Leu Arg Leu Leu 
225                 230                 235                 240 


Leu Thr Leu Pro Pro Pro Gly Pro Pro Glu Arg Thr Val Leu His Ala 
                245                 250                 255     


Asn Leu Ala Ala Cys Gln Leu Leu Leu Gly Gln Pro Gln Leu Ala Ala 
            260                 265                 270         


Gln Ser Cys Asp Arg Val Leu Glu Arg Glu Pro Gly His Leu Lys Ala 
        275                 280                 285             


Leu Tyr Arg Arg Gly Val Ala Gln Ala Ala Leu Gly Asn Leu Glu Lys 
    290                 295                 300                 


Ala Thr Ala Asp Leu Lys Lys Val Leu Ala Ile Asp Pro Lys Asn Arg 
305                 310                 315                 320 


Ala Ala Gln Glu Glu Leu Gly Lys Val Val Ile Gln Gly Lys Asn Gln 
                325                 330                 335     


Asp Ala Gly Leu Ala Gln Gly Leu Arg Lys Met Phe Gly 
            340                 345                 


<210>  4081
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKRP__Homo_sapiens__XP_011525609

<400>  4081

Met Arg Leu Thr Arg Cys Gln Ala Ala Leu Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      


Asn Leu Leu Val Leu Phe Tyr Val Ser Trp Leu Gln His Gln Pro Arg 
            20                  25                  30          


Asn Ser Arg Ala Arg Gly Pro Arg Arg Ala Ser Ala Ala Gly Pro Arg 
        35                  40                  45              


Val Thr Val Leu Val Arg Glu Phe Glu Ala Phe Asp Asn Ala Val Pro 
    50                  55                  60                  


Glu Leu Val Asp Ser Phe Leu Gln Gln Asp Pro Ala Gln Pro Val Val 
65                  70                  75                  80  


Val Ala Ala Asp Thr Leu Pro Tyr Pro Pro Leu Ala Leu Pro Arg Ile 
                85                  90                  95      


Pro Asn Val Arg Leu Ala Leu Leu Gln Pro Ala Leu Asp Arg Pro Ala 
            100                 105                 110         


Ala Ala Ser Arg Pro Glu Thr Tyr Val Ala Thr Glu Phe Val Ala Leu 
        115                 120                 125             


Val Pro Asp Gly Ala Arg Ala Glu Ala Pro Gly Leu Leu Glu Arg Met 
    130                 135                 140                 


Val Glu Ala Leu Arg Ala Gly Ser Ala Arg Leu Val Ala Ala Pro Val 
145                 150                 155                 160 


Ala Thr Ala Asn Pro Ala Arg Cys Leu Ala Leu Asn Val Ser Leu Arg 
                165                 170                 175     


Glu Trp Thr Ala Arg Tyr Gly Ala Ala Pro Ala Ala Pro Arg Cys Asp 
            180                 185                 190         


Ala Leu Asp Gly Asp Ala Val Val Leu Leu Arg Ala Arg Asp Leu Phe 
        195                 200                 205             


Asn Leu Ser Ala Pro Leu Ala Arg Pro Val Gly Thr Ser Leu Phe Leu 
    210                 215                 220                 


Gln Thr Ala Leu Arg Gly Trp Ala Val Gln Leu Leu Asp Leu Thr Phe 
225                 230                 235                 240 


Ala Ala Ala Arg Gln Pro Pro Leu Ala Thr Ala His Ala Arg Trp Lys 
                245                 250                 255     


Ala Glu Arg Glu Gly Arg Ala Arg Arg Ala Ala Leu Leu Arg Ala Leu 
            260                 265                 270         


Gly Ile Arg Leu Val Ser Trp Glu Gly Gly Arg Leu Glu Trp Phe Gly 
        275                 280                 285             


Cys Asn Lys Glu Thr Thr Arg Cys Phe Gly Thr Val Val Gly Asp Thr 
    290                 295                 300                 


Pro Ala Tyr Leu Tyr Glu Glu Arg Trp Thr Pro Pro Cys Cys Leu Arg 
305                 310                 315                 320 


Ala Leu Arg Glu Thr Ala Arg Tyr Val Val Gly Val Leu Glu Ala Ala 
                325                 330                 335     


Gly Val Arg Tyr Trp Leu Glu Gly Gly Ser Leu Leu Gly Ala Ala Arg 
            340                 345                 350         


His Gly Asp Ile Ile Pro Trp Asp Tyr Asp Val Asp Leu Gly Ile Tyr 
        355                 360                 365             


Leu Glu Asp Val Gly Asn Cys Glu Gln Leu Arg Gly Ala Glu Ala Gly 
    370                 375                 380                 


Ser Val Val Asp Glu Arg Gly Phe Val Trp Glu Lys Ala Val Glu Gly 
385                 390                 395                 400 


Asp Phe Phe Arg Val Gln Tyr Ser Glu Ser Asn His Leu His Val Asp 
                405                 410                 415     


Leu Trp Pro Phe Tyr Pro Arg Asn Gly Val Met Thr Lys Asp Thr Trp 
            420                 425                 430         


Leu Asp His Arg Gln Asp Val Glu Phe Pro Glu His Phe Leu Gln Pro 
        435                 440                 445             


Leu Val Pro Leu Pro Phe Ala Gly Phe Val Ala Gln Ala Pro Asn Asn 
    450                 455                 460                 


Tyr Arg Arg Phe Leu Glu Leu Lys Phe Gly Pro Gly Val Ile Glu Asn 
465                 470                 475                 480 


Pro Gln Tyr Pro Asn Pro Ala Leu Leu Ser Leu Thr Gly Ser Gly 
                485                 490                 495 


<210>  4082
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FKTN__Homo_sapiens__NP_001073270

<400>  4082

Met Ser Arg Ile Asn Lys Asn Val Val Leu Ala Leu Leu Thr Leu Thr 
1               5                   10                  15      


Ser Ser Ala Phe Leu Leu Phe Gln Leu Tyr Tyr Tyr Lys His Tyr Leu 
            20                  25                  30          


Ser Thr Lys Asn Gly Ala Gly Leu Ser Lys Ser Lys Gly Ser Arg Ile 
        35                  40                  45              


Gly Phe Asp Ser Thr Gln Trp Arg Ala Val Lys Lys Phe Ile Met Leu 
    50                  55                  60                  


Thr Ser Asn Gln Asn Val Pro Val Phe Leu Ile Asp Pro Leu Ile Leu 
65                  70                  75                  80  


Glu Leu Ile Asn Lys Asn Phe Glu Gln Val Lys Asn Thr Ser His Gly 
                85                  90                  95      


Ser Thr Ser Gln Cys Lys Phe Phe Cys Val Pro Arg Asp Phe Thr Ala 
            100                 105                 110         


Phe Ala Leu Gln Tyr His Leu Trp Lys Asn Glu Glu Gly Trp Phe Arg 
        115                 120                 125             


Ile Ala Glu Asn Met Gly Phe Gln Cys Leu Lys Ile Glu Ser Lys Asp 
    130                 135                 140                 


Pro Arg Leu Asp Gly Ile Asp Ser Leu Ser Gly Thr Glu Ile Pro Leu 
145                 150                 155                 160 


His Tyr Ile Cys Lys Leu Ala Thr His Ala Ile His Leu Val Val Phe 
                165                 170                 175     


His Glu Arg Ser Gly Asn Tyr Leu Trp His Gly His Leu Arg Leu Lys 
            180                 185                 190         


Glu His Ile Asp Arg Lys Phe Val Pro Phe Arg Lys Leu Gln Phe Gly 
        195                 200                 205             


Arg Tyr Pro Gly Ala Phe Asp Arg Pro Glu Leu Gln Gln Val Thr Val 
    210                 215                 220                 


Asp Gly Leu Glu Val Leu Ile Pro Lys Asp Pro Met His Phe Val Glu 
225                 230                 235                 240 


Glu Val Pro His Ser Arg Phe Ile Glu Cys Arg Tyr Lys Glu Ala Arg 
                245                 250                 255     


Ala Phe Phe Gln Gln Tyr Leu Asp Asp Asn Thr Val Glu Ala Val Ala 
            260                 265                 270         


Phe Arg Lys Ser Ala Lys Glu Leu Leu Gln Leu Ala Ala Lys Thr Leu 
        275                 280                 285             


Asn Lys Leu Gly Val Pro Phe Trp Leu Ser Ser Gly Thr Cys Leu Gly 
    290                 295                 300                 


Trp Tyr Arg Gln Cys Asn Ile Ile Pro Tyr Ser Lys Asp Val Asp Leu 
305                 310                 315                 320 


Gly Ile Phe Ile Gln Asp Tyr Lys Ser Asp Ile Ile Leu Ala Phe Gln 
                325                 330                 335     


Asp Ala Gly Leu Pro Leu Lys His Lys Phe Gly Lys Val Glu Asp Ser 
            340                 345                 350         


Leu Glu Leu Ser Phe Gln Gly Lys Asp Asp Val Lys Leu Asp Val Phe 
        355                 360                 365             


Phe Phe Tyr Glu Glu Thr Asp His Met Trp Asn Gly Gly Thr Gln Ala 
    370                 375                 380                 


Lys Thr Gly Lys Lys Phe Lys Tyr Leu Phe Pro Lys Phe Thr Leu Cys 
385                 390                 395                 400 


Trp Thr Glu Phe Val Asp Met Lys Val His Val Pro Cys Glu Thr Leu 
                405                 410                 415     


Glu Tyr Ile Glu Ala Asn Tyr Gly Lys Thr Trp Lys Ile Pro Val Lys 
            420                 425                 430         


Thr Trp Asp Trp Lys Arg Ser Pro Pro Asn Val Gln Pro Asn Gly Ile 
        435                 440                 445             


Trp Pro Ile Ser Glu Trp Asp Glu Val Ile Gln Leu Tyr 
    450                 455                 460     


<210>  4083
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAD1__Homo_sapiens__NP_001171820

<400>  4083

Met Thr Ser Arg Ala Ser Glu Leu Ser Pro Gly Arg Ser Val Thr Ala 
1               5                   10                  15      


Gly Ile Ile Ile Val Gly Asp Glu Ile Leu Lys Gly His Thr Gln Asp 
            20                  25                  30          


Thr Asn Thr Phe Phe Leu Cys Arg Thr Leu Arg Ser Leu Gly Val Gln 
        35                  40                  45              


Val Cys Arg Val Ser Val Val Pro Asp Glu Val Ala Thr Ile Ala Ala 
    50                  55                  60                  


Glu Val Thr Ser Phe Ser Asn Arg Phe Thr His Val Leu Thr Ala Gly 
65                  70                  75                  80  


Gly Ile Gly Pro Thr His Asp Asp Val Thr Phe Glu Ala Val Ala Gln 
                85                  90                  95      


Ala Phe Gly Asp Glu Leu Lys Pro His Pro Lys Leu Glu Ala Ala Thr 
            100                 105                 110         


Lys Ala Leu Gly Gly Glu Gly Trp Glu Lys Leu Ser Leu Val Pro Ser 
        115                 120                 125             


Ser Ala Arg Leu His Tyr Gly Thr Asp Pro Cys Thr Gly Gln Pro Phe 
    130                 135                 140                 


Arg Phe Pro Leu Val Ser Val Arg Asn Val Tyr Leu Phe Pro Gly Ile 
145                 150                 155                 160 


Pro Glu Leu Leu Arg Arg Val Leu Glu Gly Met Lys Gly Leu Phe Gln 
                165                 170                 175     


Asn Pro Ala Val Gln Phe His Ser Lys Glu Leu Tyr Val Ala Ala Asp 
            180                 185                 190         


Glu Ala Ser Ile Ala Pro Ile Leu Ala Glu Ala Gln Ala His Phe Gly 
        195                 200                 205             


Arg Arg Leu Gly Leu Gly Ser Tyr Pro Asp Trp Gly Ser Asn Tyr Tyr 
    210                 215                 220                 


Gln Val Lys Leu Thr Leu Asp Ser Glu Glu Glu Gly Pro Leu Glu Glu 
225                 230                 235                 240 


Cys Leu Ala Tyr Leu Thr Ala Arg Leu Pro Gln Gly Ser Leu Val Pro 
                245                 250                 255     


Tyr Met Pro Asn Ala Val Glu Gln Ala Ser Glu Ala Val Tyr Lys Leu 
            260                 265                 270         


Ala Glu Ser Gly Ser Ser Leu Gly Lys Lys Val Ala Gly Ala Leu Gln 
        275                 280                 285             


Thr Ile Glu Thr Ser Leu Ala Gln Tyr Ser Leu Thr Gln Leu Cys Val 
    290                 295                 300                 


Gly Phe Asn Gly Gly Lys Asp Cys Thr Ala Leu Leu His Leu Phe His 
305                 310                 315                 320 


Ala Ala Val Gln Arg Lys Leu Pro Asp Val Pro Asn Pro Leu Gln Ile 
                325                 330                 335     


Leu Tyr Ile Arg Ser Ile Ser Pro Phe Pro Glu Leu Glu Gln Phe Leu 
            340                 345                 350         


Gln Asp Thr Ile Lys Arg Tyr Asn Leu Gln Met Leu Glu Ala Glu Gly 
        355                 360                 365             


Ser Met Lys Gln Ala Leu Gly Glu Leu Gln Ala Arg His Pro Gln Leu 
    370                 375                 380                 


Glu Ala Val Leu Met Gly Thr Arg Arg Thr Asp Pro Tyr Ser Cys Ser 
385                 390                 395                 400 


Leu Cys Pro Phe Ser Pro Thr Asp Pro Gly Trp Pro Ala Phe Met Arg 
                405                 410                 415     


Ile Asn Pro Leu Leu Asp Trp Thr Tyr Arg Asp Ile Trp Asp Phe Leu 
            420                 425                 430         


Arg Gln Leu Phe Val Pro Tyr Cys Ile Leu Tyr Asp Arg Gly 
        435                 440                 445     


<210>  4084
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLCN__Homo_sapiens__NP_653207

<400>  4084

Met Asn Ala Ile Val Ala Leu Cys His Phe Cys Glu Leu His Gly Pro 
1               5                   10                  15      


Arg Thr Leu Phe Cys Thr Glu Val Leu His Ala Pro Leu Pro Gln Gly 
            20                  25                  30          


Asp Gly Asn Glu Asp Ser Pro Gly Gln Gly Glu Gln Ala Glu Glu Glu 
        35                  40                  45              


Glu Gly Gly Ile Gln Met Asn Ser Arg Met Arg Ala His Ser Pro Ala 
    50                  55                  60                  


Glu Gly Ala Ser Val Glu Ser Ser Ser Pro Gly Pro Lys Lys Ser Asp 
65                  70                  75                  80  


Met Cys Glu Gly Cys Arg Ser Leu Ala Ala Gly His Pro Gly Tyr Ile 
                85                  90                  95      


Ser His Asp Lys Glu Thr Ser Ile Lys Tyr Val Ser His Gln His Pro 
            100                 105                 110         


Ser His Pro Gln Leu Phe Ser Ile Val Arg Gln Ala Cys Val Arg Ser 
        115                 120                 125             


Leu Ser Cys Glu Val Cys Pro Gly Arg Glu Gly Pro Ile Phe Phe Gly 
    130                 135                 140                 


Asp Glu Gln His Gly Phe Val Phe Ser His Thr Phe Phe Ile Lys Asp 
145                 150                 155                 160 


Ser Leu Ala Arg Gly Phe Gln Arg Trp Tyr Ser Ile Ile Thr Ile Met 
                165                 170                 175     


Met Asp Arg Ile Tyr Leu Ile Asn Ser Trp Pro Phe Leu Leu Gly Lys 
            180                 185                 190         


Val Arg Gly Ile Ile Asp Glu Leu Gln Gly Lys Ala Leu Lys Val Phe 
        195                 200                 205             


Glu Ala Glu Gln Phe Gly Cys Pro Gln Arg Ala Gln Arg Met Asn Thr 
    210                 215                 220                 


Ala Phe Thr Pro Phe Leu His Gln Arg Asn Gly Asn Ala Ala Arg Ser 
225                 230                 235                 240 


Leu Thr Ser Leu Thr Ser Asp Asp Asn Leu Trp Ala Cys Leu His Thr 
                245                 250                 255     


Ser Phe Ala Trp Leu Leu Lys Ala Cys Gly Ser Arg Leu Thr Glu Lys 
            260                 265                 270         


Leu Leu Glu Gly Ala Pro Thr Glu Asp Thr Leu Val Gln Met Glu Lys 
        275                 280                 285             


Leu Ala Gly Glu Ala Gly Val Leu Leu Pro Gly Pro Trp Pro Gly Trp 
    290                 295                 300                 


Pro Trp Gly Gly Thr Ser Cys Leu Leu Ser Trp Gln Glu Ser Leu Arg 
305                 310                 315                 320 


Glu Gly Asn Ala Ala Leu Asn Gln Pro Arg Thr Ser Leu Arg Glu Ala 
                325                 330                 335     


His Pro Pro Ile Ser Val 
            340         


<210>  4085
<211>  2391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLG2__Homo_sapiens__NP_001014364

<400>  4085

Met Thr Asp Leu Leu Arg Ser Val Val Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Lys Tyr Thr Lys Gln Asp Gly Glu Cys Gly Thr Leu Ser Lys Gly Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Leu His Pro Val Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Thr Val Asp Val Ile Met His Met Leu Asp Arg Asp 
    50                  55                  60                  


His Asp Arg Arg Leu Asp Phe Thr Glu Phe Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Thr Met Ala Cys Asn Lys Val Leu Ser Lys Glu Tyr Cys Lys Ala 
                85                  90                  95      


Ser Gly Ser Lys Lys His Arg Arg Gly His Arg His Gln Glu Glu Glu 
            100                 105                 110         


Ser Glu Thr Glu Glu Asp Glu Glu Asp Thr Pro Gly His Lys Ser Gly 
        115                 120                 125             


Tyr Arg His Ser Ser Trp Ser Glu Gly Glu Glu His Gly Tyr Ser Ser 
    130                 135                 140                 


Gly His Ser Arg Gly Thr Val Lys Cys Arg His Gly Ser Asn Ser Arg 
145                 150                 155                 160 


Arg Leu Gly Arg Gln Gly Asn Leu Ser Ser Ser Gly Asn Gln Glu Gly 
                165                 170                 175     


Ser Gln Lys Arg Tyr His Arg Ser Ser Cys Gly His Ser Trp Ser Gly 
            180                 185                 190         


Gly Lys Asp Arg His Gly Ser Ser Ser Val Glu Leu Arg Glu Arg Ile 
        195                 200                 205             


Asn Lys Ser His Ile Ser Pro Ser Arg Glu Ser Gly Glu Glu Tyr Glu 
    210                 215                 220                 


Ser Gly Ser Gly Ser Asn Ser Trp Glu Arg Lys Gly His Gly Gly Leu 
225                 230                 235                 240 


Ser Cys Gly Leu Glu Thr Ser Gly His Glu Ser Asn Ser Thr Gln Ser 
                245                 250                 255     


Arg Ile Arg Glu Gln Lys Leu Gly Ser Ser Cys Ser Gly Ser Gly Asp 
            260                 265                 270         


Ser Gly Arg Arg Ser His Ala Cys Gly Tyr Ser Asn Ser Ser Gly Cys 
        275                 280                 285             


Gly Arg Pro Gln Asn Ala Ser Ser Ser Cys Gln Ser His Arg Phe Gly 
    290                 295                 300                 


Gly Gln Gly Asn Gln Phe Ser Tyr Ile Gln Ser Gly Cys Gln Ser Gly 
305                 310                 315                 320 


Ile Lys Gly Gly Gln Gly His Gly Cys Val Ser Gly Gly Gln Pro Ser 
                325                 330                 335     


Gly Cys Gly Gln Pro Glu Ser Asn Pro Cys Ser Gln Ser Tyr Ser Gln 
            340                 345                 350         


Arg Gly Tyr Gly Ala Arg Glu Asn Gly Gln Pro Gln Asn Cys Gly Gly 
        355                 360                 365             


Gln Trp Arg Thr Gly Ser Ser Gln Ser Ser Cys Cys Gly Gln Tyr Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gln Ser Cys Ser Asn Gly Gln His Glu Tyr Gly Ser 
385                 390                 395                 400 


Cys Gly Arg Phe Ser Asn Ser Ser Ser Ser Asn Glu Phe Ser Lys Cys 
                405                 410                 415     


Asp Gln Tyr Gly Ser Gly Ser Ser Gln Ser Thr Ser Phe Glu Gln His 
            420                 425                 430         


Gly Thr Gly Leu Ser Gln Ser Ser Gly Phe Glu Gln His Val Cys Gly 
        435                 440                 445             


Ser Gly Gln Thr Cys Gly Gln His Glu Ser Thr Ser Ser Gln Ser Leu 
    450                 455                 460                 


Gly Tyr Asp Gln His Gly Ser Ser Ser Gly Lys Thr Ser Gly Phe Gly 
465                 470                 475                 480 


Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln Cys Gly 
                485                 490                 495     


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Val Ser 
            500                 505                 510         


Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Val Ser Gly Gln Ser 
        515                 520                 525             


Ser Gly Phe Gly Gln His Glu Ser Arg Ser Arg Gln Ser Ser Tyr Gly 
    530                 535                 540                 


Gln His Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly Gln Tyr Gly 
545                 550                 555                 560 


Ser Arg Glu Thr Ser Gly Phe Gly Gln His Gly Leu Gly Ser Gly Gln 
                565                 570                 575     


Ser Thr Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln Ser Ser Gly 
            580                 585                 590         


Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln 
        595                 600                 605             


His Glu Ser Arg Ser Gly Gln Ser Ser Tyr Gly Gln His Ser Ser Gly 
    610                 615                 620                 


Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Arg Gln Thr Ser 
625                 630                 635                 640 


Gly Phe Gly Gln His Gly Ser Gly Ser Ser Gln Ser Thr Gly Phe Gly 
                645                 650                 655     


Gln Tyr Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Val 
            660                 665                 670         


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser 
        675                 680                 685             


Gly His Ser Ser Tyr Gly Gln His Gly Phe Gly Ser Ser Gln Ser Ser 
    690                 695                 700                 


Gly Tyr Gly Gln His Gly Ser Ser Ser Gly Gln Thr Ser Gly Phe Gly 
705                 710                 715                 720 


Gln His Glu Leu Ser Ser Gly Gln Ser Ser Ser Phe Gly Gln His Gly 
                725                 730                 735     


Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln His Gly Ser Gly Ser 
            740                 745                 750         


Gly Gln Ser Ser Gly Phe Gly Gln His Glu Ser Arg Ser Gly Gln Ser 
        755                 760                 765             


Ser Tyr Gly Gln His Ser Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly 
    770                 775                 780                 


Gln His Gly Ser Arg Gln Thr Ser Gly Phe Gly Gln His Gly Ser Gly 
785                 790                 795                 800 


Ser Ser Gln Ser Thr Gly Phe Gly Gln Tyr Gly Ser Gly Ser Gly Gln 
                805                 810                 815     


Ser Ala Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly 
            820                 825                 830         


Phe Gly Gln His Glu Ser Arg Ser His Gln Ser Ser Tyr Gly Gln His 
        835                 840                 845             


Gly Ser Gly Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser 
    850                 855                 860                 


Ser Gly Gln Thr Ser Gly Phe Gly Gln His Arg Ser Ser Ser Gly Gln 
865                 870                 875                 880 


Tyr Ser Gly Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly 
                885                 890                 895     


Phe Gly Gln His Gly Thr Gly Ser Gly Gln Tyr Ser Gly Phe Gly Gln 
            900                 905                 910         


His Glu Ser Arg Ser His Gln Ser Ser Tyr Gly Gln His Gly Ser Gly 
        915                 920                 925             


Ser Ser Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser Ser Gly Gln 
    930                 935                 940                 


Thr Phe Gly Phe Gly Gln His Arg Ser Gly Ser Gly Gln Ser Ser Gly 
945                 950                 955                 960 


Phe Gly Gln His Gly Ser Gly Ser Gly Gln Ser Ser Gly Phe Gly Gln 
                965                 970                 975     


His Glu Ser Gly Ser Gly Lys Ser Ser Gly Phe Gly Gln His Glu Ser 
            980                 985                 990         


Arg Ser Ser Gln Ser Asn Tyr Gly  Gln His Gly Ser Gly  Ser Ser Gln 
        995                 1000                 1005             


Ser Ser  Gly Tyr Gly Gln His  Gly Ser Ser Ser Gly  Gln Thr Thr 
    1010                 1015                 1020             


Gly Phe  Gly Gln His Arg Ser  Ser Ser Gly Gln Tyr  Ser Gly Phe 
    1025                 1030                 1035             


Gly Gln  His Gly Ser Gly Ser  Asp Gln Ser Ser Gly  Phe Gly Gln 
    1040                 1045                 1050             


His Gly  Thr Gly Ser Gly Gln  Ser Ser Gly Phe Gly  Gln Tyr Glu 
    1055                 1060                 1065             


Ser Arg  Ser Arg Gln Ser Ser  Tyr Gly Gln His Gly  Ser Gly Ser 
    1070                 1075                 1080             


Ser Gln  Ser Ser Gly Tyr Gly  Gln His Gly Ser Asn  Ser Gly Gln 
    1085                 1090                 1095             


Thr Ser  Gly Phe Gly Gln His  Arg Pro Gly Ser Gly  Gln Ser Ser 
    1100                 1105                 1110             


Gly Phe  Gly Gln Tyr Gly Ser  Gly Ser Gly Gln Ser  Ser Gly Phe 
    1115                 1120                 1125             


Gly Gln  His Gly Ser Gly Thr  Gly Lys Ser Ser Gly  Phe Ala Gln 
    1130                 1135                 1140             


His Glu  Tyr Arg Ser Gly Gln  Ser Ser Tyr Gly Gln  His Gly Thr 
    1145                 1150                 1155             


Gly Ser  Ser Gln Ser Ser Gly  Cys Gly Gln His Glu  Ser Gly Ser 
    1160                 1165                 1170             


Gly Pro  Thr Thr Ser Phe Gly  Gln His Val Ser Gly  Ser Asp Asn 
    1175                 1180                 1185             


Phe Ser  Ser Ser Gly Gln His  Ile Ser Asp Ser Gly  Gln Ser Thr 
    1190                 1195                 1200             


Gly Phe  Gly Gln Tyr Gly Ser  Gly Ser Gly Gln Ser  Thr Gly Leu 
    1205                 1210                 1215             


Gly Gln  Gly Glu Ser Gln Gln  Val Glu Ser Gly Ser  Thr Val His 
    1220                 1225                 1230             


Gly Arg  Gln Glu Thr Thr His  Gly Gln Thr Ile Asn  Thr Thr Arg 
    1235                 1240                 1245             


His Ser  Gln Ser Gly Gln Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1250                 1255                 1260             


Val Thr  Arg Arg Arg Arg Ser  Ser Gln Ser Glu Asn  Ser Asp Ser 
    1265                 1270                 1275             


Glu Val  His Ser Lys Val Ser  His Arg His Ser Glu  His Ile His 
    1280                 1285                 1290             


Thr Gln  Ala Gly Ser His Tyr  Pro Lys Ser Gly Ser  Thr Val Arg 
    1295                 1300                 1305             


Arg Arg  Gln Gly Thr Thr His  Gly Gln Arg Gly Asp  Thr Thr Arg 
    1310                 1315                 1320             


His Gly  His Ser Gly His Gly  Gln Ser Thr Gln Thr  Gly Ser Arg 
    1325                 1330                 1335             


Thr Ser  Gly Arg Gln Arg Phe  Ser His Ser Asp Ala  Thr Asp Ser 
    1340                 1345                 1350             


Glu Val  His Ser Gly Val Ser  His Arg Pro His Ser  Gln Glu Gln 
    1355                 1360                 1365             


Thr His  Ser Gln Ala Gly Ser  Gln His Gly Glu Ser  Glu Ser Thr 
    1370                 1375                 1380             


Val His  Glu Arg His Glu Thr  Thr Tyr Gly Gln Thr  Gly Glu Ala 
    1385                 1390                 1395             


Thr Gly  His Gly His Ser Gly  His Gly Gln Ser Thr  Gln Arg Gly 
    1400                 1405                 1410             


Ser Arg  Thr Thr Gly Arg Arg  Gly Ser Gly His Ser  Glu Ser Ser 
    1415                 1420                 1425             


Asp Ser  Glu Val His Ser Gly  Gly Ser His Arg Pro  Gln Ser Gln 
    1430                 1435                 1440             


Glu Gln  Thr His Gly Gln Ala  Gly Ser Gln His Gly  Glu Ser Gly 
    1445                 1450                 1455             


Ser Thr  Val His Gly Arg His  Gly Thr Thr His Gly  Gln Thr Gly 
    1460                 1465                 1470             


Asp Thr  Thr Arg His Ala His  Tyr His His Gly Lys  Ser Thr Gln 
    1475                 1480                 1485             


Arg Gly  Ser Ser Thr Thr Gly  Arg Arg Gly Ser Gly  His Ser Glu 
    1490                 1495                 1500             


Ser Ser  Asp Ser Glu Val His  Ser Gly Gly Ser His  Thr His Ser 
    1505                 1510                 1515             


Gly His  Thr His Gly Gln Ser  Gly Ser Gln His Gly  Glu Ser Glu 
    1520                 1525                 1530             


Ser Ile  Ile His Asp Arg His  Arg Ile Thr His Gly  Gln Thr Gly 
    1535                 1540                 1545             


Asp Thr  Thr Arg His Ser Tyr  Ser Gly His Glu Gln  Thr Thr Gln 
    1550                 1555                 1560             


Thr Gly  Ser Arg Thr Thr Gly  Arg Gln Arg Thr Ser  His Ser Glu 
    1565                 1570                 1575             


Ser Thr  Asp Ser Glu Val His  Ser Gly Gly Ser His  Arg Pro His 
    1580                 1585                 1590             


Ser Arg  Glu His Thr Tyr Gly  Gln Ala Gly Ser Gln  His Glu Glu 
    1595                 1600                 1605             


Pro Glu  Phe Thr Val His Glu  Arg His Gly Thr Thr  His Gly Gln 
    1610                 1615                 1620             


Ile Gly  Asp Thr Thr Gly His  Ser His Ser Gly His  Gly Gln Ser 
    1625                 1630                 1635             


Thr Gln  Arg Gly Ser Arg Thr  Thr Gly Arg Gln Arg  Ser Ser His 
    1640                 1645                 1650             


Ser Glu  Ser Ser Asp Ser Glu  Val His Ser Gly Val  Ser His Thr 
    1655                 1660                 1665             


His Thr  Gly His Thr His Gly  Gln Ala Gly Ser Gln  His Gly Gln 
    1670                 1675                 1680             


Ser Glu  Ser Ile Val Pro Glu  Arg His Gly Thr Thr  His Gly Gln 
    1685                 1690                 1695             


Thr Gly  Asp Thr Thr Arg His  Ala His Tyr His His  Gly Leu Thr 
    1700                 1705                 1710             


Thr Gln  Thr Gly Ser Arg Thr  Thr Gly Arg Arg Gly  Ser Gly His 
    1715                 1720                 1725             


Ser Glu  Tyr Ser Asp Ser Glu  Gly Tyr Ser Gly Val  Ser His Thr 
    1730                 1735                 1740             


His Ser  Gly His Thr His Gly  Gln Ala Arg Ser Gln  His Gly Glu 
    1745                 1750                 1755             


Ser Glu  Ser Ile Val His Glu  Arg His Gly Thr Ile  His Gly Gln 
    1760                 1765                 1770             


Thr Gly  Asp Thr Thr Arg His  Ala His Ser Gly His  Gly Gln Ser 
    1775                 1780                 1785             


Thr Gln  Thr Gly Ser Arg Thr  Thr Gly Arg Arg Ser  Ser Gly His 
    1790                 1795                 1800             


Ser Glu  Tyr Ser Asp Ser Glu  Gly His Ser Gly Phe  Ser Gln Arg 
    1805                 1810                 1815             


Pro His  Ser Arg Gly His Thr  His Gly Gln Ala Gly  Ser Gln His 
    1820                 1825                 1830             


Gly Glu  Ser Glu Ser Ile Val  Asp Glu Arg His Gly  Thr Thr His 
    1835                 1840                 1845             


Gly Gln  Thr Gly Asp Thr Ser  Gly His Ser Gln Ser  Gly His Gly 
    1850                 1855                 1860             


Gln Ser  Thr Gln Ser Gly Ser  Ser Thr Thr Gly Arg  Arg Arg Ser 
    1865                 1870                 1875             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Gly Gly Ser 
    1880                 1885                 1890             


His Thr  His Ser Gly His Thr  His Ser Gln Ala Arg  Ser Gln His 
    1895                 1900                 1905             


Gly Glu  Ser Glu Ser Thr Val  His Lys Arg His Gln  Thr Thr His 
    1910                 1915                 1920             


Gly Gln  Thr Gly Asp Thr Thr  Glu His Gly His Pro  Ser His Gly 
    1925                 1930                 1935             


Gln Thr  Ile Gln Thr Gly Ser  Arg Thr Thr Gly Arg  Arg Gly Ser 
    1940                 1945                 1950             


Gly His  Ser Glu Tyr Ser Asp  Ser Glu Gly Pro Ser  Gly Val Ser 
    1955                 1960                 1965             


His Thr  His Ser Gly His Thr  His Gly Gln Ala Gly  Ser His Tyr 
    1970                 1975                 1980             


Pro Glu  Ser Gly Ser Ser Val  His Glu Arg His Gly  Thr Thr His 
    1985                 1990                 1995             


Gly Gln  Thr Ala Asp Thr Thr  Arg His Gly His Ser  Gly His Gly 
    2000                 2005                 2010             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Thr Gly Arg  Arg Ala Ser 
    2015                 2020                 2025             


Gly His  Ser Glu Tyr Ser Asp  Ser Glu Gly His Ser  Gly Val Ser 
    2030                 2035                 2040             


His Thr  His Ser Gly His Ala  His Gly Gln Ala Gly  Ser Gln His 
    2045                 2050                 2055             


Gly Glu  Ser Gly Ser Ser Val  His Glu Arg His Gly  Thr Thr His 
    2060                 2065                 2070             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Ala His Ser  Gly His Gly 
    2075                 2080                 2085             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Ala Gly Arg  Arg Gly Ser 
    2090                 2095                 2100             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Gly Val Ser 
    2105                 2110                 2115             


His Thr  His Ser Gly His Thr  Tyr Gly Gln Ala Arg  Ser Gln His 
    2120                 2125                 2130             


Gly Glu  Ser Gly Ser Ala Ile  His Gly Arg Gln Gly  Thr Ile His 
    2135                 2140                 2145             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Gly Gln Ser  Gly His Gly 
    2150                 2155                 2160             


Gln Ser  Thr Gln Thr Gly Ser  Arg Thr Thr Gly Arg  Gln Arg Ser 
    2165                 2170                 2175             


Ser His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Glu Ala Ser 
    2180                 2185                 2190             


Pro Thr  His Ser Gly His Thr  His Ser Gln Ala Gly  Ser Arg His 
    2195                 2200                 2205             


Gly Gln  Ser Gly Ser Ser Gly  His Gly Arg Gln Gly  Thr Thr His 
    2210                 2215                 2220             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Ala His Tyr  Gly Tyr Gly 
    2225                 2230                 2235             


Gln Ser  Thr Gln Arg Gly Ser  Arg Thr Thr Gly Arg  Arg Gly Ser 
    2240                 2245                 2250             


Gly His  Ser Glu Ser Ser Asp  Ser Glu Val His Ser  Trp Gly Ser 
    2255                 2260                 2265             


His Thr  His Ser Gly His Ile  Gln Gly Gln Ala Gly  Ser Gln Gln 
    2270                 2275                 2280             


Arg Gln  Pro Gly Ser Thr Val  His Gly Arg Leu Glu  Thr Thr His 
    2285                 2290                 2295             


Gly Gln  Thr Gly Asp Thr Thr  Arg His Gly His Ser  Gly Tyr Gly 
    2300                 2305                 2310             


Gln Ser  Thr Gln Thr Gly Ser  Arg Ser Ser Arg Ala  Ser His Phe 
    2315                 2320                 2325             


Gln Ser  His Ser Ser Glu Arg  Gln Arg His Gly Ser  Ser Gln Val 
    2330                 2335                 2340             


Trp Lys  His Gly Ser Tyr Gly  Pro Ala Glu Tyr Asp  Tyr Gly His 
    2345                 2350                 2355             


Thr Gly  Tyr Gly Pro Ser Gly  Gly Ser Arg Lys Ser  Ile Ser Asn 
    2360                 2365                 2370             


Ser His  Leu Ser Trp Ser Thr  Asp Ser Thr Ala Asn  Lys Gln Leu 
    2375                 2380                 2385             


Ser Arg  His 
    2390     


<210>  4086
<211>  4061
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLG__Homo_sapiens__NP_002007

<400>  4086

Met Ser Thr Leu Leu Glu Asn Ile Phe Ala Ile Ile Asn Leu Phe Lys 
1               5                   10                  15      


Gln Tyr Ser Lys Lys Asp Lys Asn Thr Asp Thr Leu Ser Lys Lys Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Lys Glu Phe Arg Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asp Asp Pro Asp Met Val Asp Val Phe Met Asp His Leu Asp Ile Asp 
    50                  55                  60                  


His Asn Lys Lys Ile Asp Phe Thr Glu Phe Leu Leu Met Val Phe Lys 
65                  70                  75                  80  


Leu Ala Gln Ala Tyr Tyr Glu Ser Thr Arg Lys Glu Asn Leu Pro Ile 
                85                  90                  95      


Ser Gly His Lys His Arg Lys His Ser His His Asp Lys His Glu Asp 
            100                 105                 110         


Asn Lys Gln Glu Glu Asn Lys Glu Asn Arg Lys Arg Pro Ser Ser Leu 
        115                 120                 125             


Glu Arg Arg Asn Asn Arg Lys Gly Asn Lys Gly Arg Ser Lys Ser Pro 
    130                 135                 140                 


Arg Glu Thr Gly Gly Lys Arg His Glu Ser Ser Ser Glu Lys Lys Glu 
145                 150                 155                 160 


Arg Lys Gly Tyr Ser Pro Thr His Arg Glu Glu Glu Tyr Gly Lys Asn 
                165                 170                 175     


His His Asn Ser Ser Lys Lys Glu Lys Asn Lys Thr Glu Asn Thr Arg 
            180                 185                 190         


Leu Gly Asp Asn Arg Lys Arg Leu Ser Glu Arg Leu Glu Glu Lys Glu 
        195                 200                 205             


Asp Asn Glu Glu Gly Val Tyr Asp Tyr Glu Asn Thr Gly Arg Met Thr 
    210                 215                 220                 


Gln Lys Trp Ile Gln Ser Gly His Ile Ala Thr Tyr Tyr Thr Ile Gln 
225                 230                 235                 240 


Asp Glu Ala Tyr Asp Thr Thr Asp Ser Leu Leu Glu Glu Asn Lys Ile 
                245                 250                 255     


Tyr Glu Arg Ser Arg Ser Ser Asp Gly Lys Ser Ser Ser Gln Val Asn 
            260                 265                 270         


Arg Ser Arg His Glu Asn Thr Ser Gln Val Pro Leu Gln Glu Ser Arg 
        275                 280                 285             


Thr Arg Lys Arg Arg Gly Ser Arg Val Ser Gln Asp Arg Asp Ser Glu 
    290                 295                 300                 


Gly His Ser Glu Asp Ser Glu Arg His Ser Gly Ser Ala Ser Arg Asn 
305                 310                 315                 320 


His His Gly Ser Ala Trp Glu Gln Ser Arg Asp Gly Ser Arg His Pro 
                325                 330                 335     


Arg Ser His Asp Glu Asp Arg Ala Ser His Gly His Ser Ala Asp Ser 
            340                 345                 350         


Ser Arg Gln Ser Gly Thr Arg His Ala Glu Thr Ser Ser Arg Gly Gln 
        355                 360                 365             


Thr Ala Ser Ser His Glu Gln Ala Arg Ser Ser Pro Gly Glu Arg His 
    370                 375                 380                 


Gly Ser Gly His Gln Gln Ser Ala Asp Ser Ser Arg His Ser Ala Thr 
385                 390                 395                 400 


Gly Arg Gly Gln Ala Ser Ser Ala Val Ser Asp Arg Gly His Arg Gly 
                405                 410                 415     


Ser Ser Gly Ser Gln Ala Ser Asp Ser Glu Gly His Ser Glu Asn Ser 
            420                 425                 430         


Asp Thr Gln Ser Val Ser Gly His Gly Lys Ala Gly Leu Arg Gln Gln 
        435                 440                 445             


Ser His Gln Glu Ser Thr Arg Gly Arg Ser Gly Glu Arg Ser Gly Arg 
    450                 455                 460                 


Ser Gly Ser Ser Leu Tyr Gln Val Ser Thr His Glu Gln Pro Asp Ser 
465                 470                 475                 480 


Ala His Gly Arg Thr Gly Thr Ser Thr Gly Gly Arg Gln Gly Ser His 
                485                 490                 495     


His Glu Gln Ala Arg Asp Ser Ser Arg His Ser Ala Ser Gln Glu Gly 
            500                 505                 510         


Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser Arg Gly Gly Arg Gln 
        515                 520                 525             


Gly Ser His His Glu Gln Ser Val Asn Arg Ser Gly His Ser Gly Ser 
    530                 535                 540                 


His His Ser His Thr Thr Ser Gln Gly Arg Ser Asp Ala Ser His Gly 
545                 550                 555                 560 


Gln Ser Gly Ser Arg Ser Ala Ser Arg Gln Thr Arg Asn Glu Glu Gln 
                565                 570                 575     


Ser Gly Asp Gly Thr Arg His Ser Gly Ser Arg His His Glu Ala Ser 
            580                 585                 590         


Ser Gln Ala Asp Ser Ser Arg His Ser Gln Val Gly Gln Gly Gln Ser 
        595                 600                 605             


Ser Gly Pro Arg Thr Ser Arg Asn Gln Gly Ser Ser Val Ser Gln Asp 
    610                 615                 620                 


Ser Asp Ser Gln Gly His Ser Glu Asp Ser Glu Arg Trp Ser Gly Ser 
625                 630                 635                 640 


Ala Ser Arg Asn His His Gly Ser Ala Gln Glu Gln Ser Arg Asp Gly 
                645                 650                 655     


Ser Arg His Pro Arg Ser His His Glu Asp Arg Ala Gly His Gly His 
            660                 665                 670         


Ser Ala Asp Ser Ser Arg Lys Ser Gly Thr Arg His Thr Gln Asn Ser 
        675                 680                 685             


Ser Ser Gly Gln Ala Ala Ser Ser His Glu Gln Ala Arg Ser Ser Ala 
    690                 695                 700                 


Gly Glu Arg His Gly Ser Arg His Gln Leu Gln Ser Ala Asp Ser Ser 
705                 710                 715                 720 


Arg His Ser Gly Thr Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp 
                725                 730                 735     


Ser Gly His Arg Gly Ser Ser Gly Ser Gln Ala Thr Asp Ser Glu Gly 
            740                 745                 750         


His Ser Glu Asp Ser Asp Thr Gln Ser Val Ser Gly His Gly Gln Ala 
        755                 760                 765             


Gly His His Gln Gln Ser His Gln Glu Ser Ala Arg Asp Arg Ser Gly 
    770                 775                 780                 


Glu Arg Ser Arg Arg Ser Gly Ser Phe Leu Tyr Gln Val Ser Thr His 
785                 790                 795                 800 


Lys Gln Ser Glu Ser Ser His Gly Trp Thr Gly Pro Ser Thr Gly Val 
                805                 810                 815     


Arg Gln Gly Ser His His Glu Gln Ala Arg Asp Asn Ser Arg His Ser 
            820                 825                 830         


Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly Ser Ser 
        835                 840                 845             


Arg Arg Gly Arg Gln Gly Ser His His Glu Gln Ser Val Asp Arg Ser 
    850                 855                 860                 


Gly His Ser Gly Ser His His Ser His Thr Thr Ser Gln Gly Arg Ser 
865                 870                 875                 880 


Asp Ala Ser Arg Gly Gln Ser Gly Ser Arg Ser Ala Ser Arg Thr Thr 
                885                 890                 895     


Arg Asn Glu Glu Gln Ser Arg Asp Gly Ser Arg His Ser Gly Ser Arg 
            900                 905                 910         


His His Glu Ala Ser Ser His Ala Asp Ile Ser Arg His Ser Gln Ala 
        915                 920                 925             


Gly Gln Gly Gln Ser Glu Gly Ser Arg Thr Ser Arg Arg Gln Gly Ser 
    930                 935                 940                 


Ser Val Ser Gln Asp Ser Asp Ser Glu Gly His Ser Glu Asp Ser Glu 
945                 950                 955                 960 


Arg Trp Ser Gly Ser Ala Ser Arg Asn His Arg Gly Ser Ala Gln Glu 
                965                 970                 975     


Gln Ser Arg His Gly Ser Arg His Pro Arg Ser His His Glu Asp Arg 
            980                 985                 990         


Ala Gly His Gly His Ser Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Pro 
        995                 1000                 1005             


His Ala  Glu Thr Ser Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu 
    1010                 1015                 1020             


Gln Ala  Arg Ser Ser Pro Gly  Glu Arg His Gly Ser  Arg His Gln 
    1025                 1030                 1035             


Gln Ser  Ala Asp Ser Ser Arg  His Ser Gly Ile Pro  Arg Arg Gln 
    1040                 1045                 1050             


Ala Ser  Ser Ala Val Arg Asp  Ser Gly His Trp Gly  Ser Ser Gly 
    1055                 1060                 1065             


Ser Gln  Ala Ser Asp Ser Glu  Gly His Ser Glu Glu  Ser Asp Thr 
    1070                 1075                 1080             


Gln Ser  Val Ser Gly His Gly  Gln Asp Gly Pro His  Gln Gln Ser 
    1085                 1090                 1095             


His Gln  Glu Ser Ala Arg Asp  Trp Ser Gly Gly Arg  Ser Gly Arg 
    1100                 1105                 1110             


Ser Gly  Ser Phe Ile Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu 
    1115                 1120                 1125             


Ser Ala  His Gly Arg Thr Arg  Thr Ser Thr Gly Arg  Arg Gln Gly 
    1130                 1135                 1140             


Ser His  His Glu Gln Ala Arg  Asp Ser Ser Arg His  Ser Ala Ser 
    1145                 1150                 1155             


Gln Glu  Gly Gln Asp Thr Ile  Arg Ala His Pro Gly  Ser Arg Arg 
    1160                 1165                 1170             


Gly Gly  Arg Gln Gly Ser His  His Glu Gln Ser Val  Asp Arg Ser 
    1175                 1180                 1185             


Gly His  Ser Gly Ser His His  Ser His Thr Thr Ser  Gln Gly Arg 
    1190                 1195                 1200             


Ser Asp  Ala Ser His Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg 
    1205                 1210                 1215             


Gln Thr  Arg Lys Asp Lys Gln  Ser Gly Asp Gly Ser  Arg His Ser 
    1220                 1225                 1230             


Gly Ser  Arg His His Glu Ala  Ala Ser Trp Ala Asp  Ser Ser Arg 
    1235                 1240                 1245             


His Ser  Gln Val Gly Gln Glu  Gln Ser Ser Gly Ser  Arg Thr Ser 
    1250                 1255                 1260             


Arg His  Gln Gly Ser Ser Val  Ser Gln Asp Ser Asp  Ser Glu Arg 
    1265                 1270                 1275             


His Ser  Asp Asp Ser Glu Arg  Leu Ser Gly Ser Ala  Ser Arg Asn 
    1280                 1285                 1290             


His His  Gly Ser Ser Arg Glu  Gln Ser Arg Asp Gly  Ser Arg His 
    1295                 1300                 1305             


Pro Gly  Phe His Gln Glu Asp  Arg Ala Ser His Gly  His Ser Ala 
    1310                 1315                 1320             


Asp Ser  Ser Arg Gln Ser Gly  Thr His His Thr Glu  Ser Ser Ser 
    1325                 1330                 1335             


His Gly  Gln Ala Val Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro 
    1340                 1345                 1350             


Gly Glu  Arg His Gly Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser 
    1355                 1360                 1365             


Arg His  Ser Gly Ile Gly His  Arg Gln Ala Ser Ser  Ala Val Arg 
    1370                 1375                 1380             


Asp Ser  Gly His Arg Gly Ser  Ser Gly Ser Gln Val  Thr Asn Ser 
    1385                 1390                 1395             


Glu Gly  His Ser Glu Asp Ser  Asp Thr Gln Ser Val  Ser Ala His 
    1400                 1405                 1410             


Gly Gln  Ala Gly Pro His Gln  Gln Ser His Lys Glu  Ser Ala Arg 
    1415                 1420                 1425             


Gly Gln  Ser Gly Glu Ser Ser  Gly Arg Ser Arg Ser  Phe Leu Tyr 
    1430                 1435                 1440             


Gln Val  Ser Ser His Glu Gln  Ser Glu Ser Thr His  Gly Gln Thr 
    1445                 1450                 1455             


Ala Pro  Ser Thr Gly Gly Arg  Gln Gly Ser Arg His  Glu Gln Ala 
    1460                 1465                 1470             


Arg Asn  Ser Ser Arg His Ser  Ala Ser Gln Asp Gly  Gln Asp Thr 
    1475                 1480                 1485             


Ile Arg  Gly His Pro Gly Ser  Ser Arg Gly Gly Arg  Gln Gly Ser 
    1490                 1495                 1500             


Tyr His  Glu Gln Ser Val Asp  Arg Ser Gly His Ser  Gly Tyr His 
    1505                 1510                 1515             


His Ser  His Thr Thr Pro Gln  Gly Arg Ser Asp Ala  Ser His Gly 
    1520                 1525                 1530             


Gln Ser  Gly Pro Arg Ser Ala  Ser Arg Gln Thr Arg  Asn Glu Glu 
    1535                 1540                 1545             


Gln Ser  Gly Asp Gly Ser Arg  His Ser Gly Ser Arg  His His Glu 
    1550                 1555                 1560             


Pro Ser  Thr Arg Ala Gly Ser  Ser Arg His Ser Gln  Val Gly Gln 
    1565                 1570                 1575             


Gly Glu  Ser Ala Gly Ser Lys  Thr Ser Arg Arg Gln  Gly Ser Ser 
    1580                 1585                 1590             


Val Ser  Gln Asp Arg Asp Ser  Glu Gly His Ser Glu  Asp Ser Glu 
    1595                 1600                 1605             


Arg Arg  Ser Glu Ser Ala Ser  Arg Asn His Tyr Gly  Ser Ala Arg 
    1610                 1615                 1620             


Glu Gln  Ser Arg His Gly Ser  Arg Asn Pro Arg Ser  His Gln Glu 
    1625                 1630                 1635             


Asp Arg  Ala Ser His Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser 
    1640                 1645                 1650             


Gly Thr  Arg His Ala Glu Thr  Ser Ser Gly Gly Gln  Ala Ala Ser 
    1655                 1660                 1665             


Ser Gln  Glu Gln Ala Arg Ser  Ser Pro Gly Glu Arg  His Gly Ser 
    1670                 1675                 1680             


Arg His  Gln Gln Ser Ala Asp  Ser Ser Thr Asp Ser  Gly Thr Gly 
    1685                 1690                 1695             


Arg Arg  Gln Asp Ser Ser Val  Val Gly Asp Ser Gly  Asn Arg Gly 
    1700                 1705                 1710             


Ser Ser  Gly Ser Gln Ala Ser  Asp Ser Glu Gly His  Ser Glu Glu 
    1715                 1720                 1725             


Ser Asp  Thr Gln Ser Val Ser  Ala His Gly Gln Ala  Gly Pro His 
    1730                 1735                 1740             


Gln Gln  Ser His Gln Glu Ser  Thr Arg Gly Gln Ser  Gly Glu Arg 
    1745                 1750                 1755             


Ser Gly  Arg Ser Gly Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu 
    1760                 1765                 1770             


Gln Ser  Glu Ser Ala His Gly  Arg Thr Gly Pro Ser  Thr Gly Gly 
    1775                 1780                 1785             


Arg Gln  Arg Ser Arg His Glu  Gln Ala Arg Asp Ser  Ser Arg His 
    1790                 1795                 1800             


Ser Ala  Ser Gln Glu Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly 
    1805                 1810                 1815             


Ser Ser  Arg Gly Gly Arg Gln  Gly Ser His Tyr Glu  Gln Ser Val 
    1820                 1825                 1830             


Asp Ser  Ser Gly His Ser Gly  Ser His His Ser His  Thr Thr Ser 
    1835                 1840                 1845             


Gln Glu  Arg Ser Asp Val Ser  Arg Gly Gln Ser Gly  Ser Arg Ser 
    1850                 1855                 1860             


Val Ser  Arg Gln Thr Arg Asn  Glu Lys Gln Ser Gly  Asp Gly Ser 
    1865                 1870                 1875             


Arg His  Ser Gly Ser Arg His  His Glu Ala Ser Ser  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Arg His Ser Gln Val  Gly Gln Gly Gln Ser  Ser Gly Pro 
    1895                 1900                 1905             


Arg Thr  Ser Arg Asn Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp 
    1910                 1915                 1920             


Ser Gln  Gly His Ser Glu Asp  Ser Glu Arg Trp Ser  Gly Ser Ala 
    1925                 1930                 1935             


Ser Arg  Asn His Leu Gly Ser  Ala Trp Glu Gln Ser  Arg Asp Gly 
    1940                 1945                 1950             


Ser Arg  His Pro Gly Ser His  His Glu Asp Arg Ala  Gly His Gly 
    1955                 1960                 1965             


His Ser  Ala Asp Ser Ser Arg  Gln Ser Gly Thr Arg  His Thr Glu 
    1970                 1975                 1980             


Ser Ser  Ser Arg Gly Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg 
    1985                 1990                 1995             


Ser Ser  Ala Gly Glu Arg His  Gly Ser His His Gln  Leu Gln Ser 
    2000                 2005                 2010             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    2015                 2020                 2025             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Tyr Ser  Gly Ser Gln 
    2030                 2035                 2040             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    2045                 2050                 2055             


Val Ser  Ala Gln Gly Lys Ala  Gly Pro His Gln Gln  Ser His Lys 
    2060                 2065                 2070             


Glu Ser  Ala Arg Gly Gln Ser  Gly Glu Ser Ser Gly  Arg Ser Gly 
    2075                 2080                 2085             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Thr 
    2090                 2095                 2100             


His Gly  Gln Ser Ala Pro Ser  Thr Gly Gly Arg Gln  Gly Ser His 
    2105                 2110                 2115             


Tyr Asp  Gln Ala Gln Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    2120                 2125                 2130             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Pro Ser  Arg Gly Gly 
    2135                 2140                 2145             


Arg Gln  Gly Ser His Gln Glu  Gln Ser Val Asp Arg  Ser Gly His 
    2150                 2155                 2160             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    2165                 2170                 2175             


Ala Ser  Arg Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Lys Thr 
    2180                 2185                 2190             


Tyr Asp  Lys Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    2195                 2200                 2205             


His His  His Glu Ala Ser Ser  Trp Ala Asp Ser Ser  Arg His Ser 
    2210                 2215                 2220             


Leu Val  Gly Gln Gly Gln Ser  Ser Gly Pro Arg Thr  Ser Arg Pro 
    2225                 2230                 2235             


Arg Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Gly His Ser 
    2240                 2245                 2250             


Glu Asp  Ser Glu Arg Arg Ser  Gly Ser Ala Ser Arg  Asn His His 
    2255                 2260                 2265             


Gly Ser  Ala Gln Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Arg 
    2270                 2275                 2280             


Ser His  His Glu Asp Arg Ala  Gly His Gly His Ser  Ala Glu Ser 
    2285                 2290                 2295             


Ser Arg  Gln Ser Gly Thr His  His Ala Glu Asn Ser  Ser Gly Gly 
    2300                 2305                 2310             


Gln Ala  Ala Ser Ser His Glu  Gln Ala Arg Ser Ser  Ala Gly Glu 
    2315                 2320                 2325             


Arg His  Gly Ser His His Gln  Gln Ser Ala Asp Ser  Ser Arg His 
    2330                 2335                 2340             


Ser Gly  Ile Gly His Gly Gln  Ala Ser Ser Ala Val  Arg Asp Ser 
    2345                 2350                 2355             


Gly His  Arg Gly Ser Ser Gly  Ser Gln Ala Ser Asp  Ser Glu Gly 
    2360                 2365                 2370             


His Ser  Glu Asp Ser Asp Thr  Gln Ser Val Ser Ala  His Gly Gln 
    2375                 2380                 2385             


Ala Gly  Pro His Gln Gln Ser  His Gln Glu Ser Thr  Arg Gly Arg 
    2390                 2395                 2400             


Ser Ala  Gly Arg Ser Gly Arg  Ser Gly Ser Phe Leu  Tyr Gln Val 
    2405                 2410                 2415             


Ser Thr  His Glu Gln Ser Glu  Ser Ala His Gly Arg  Thr Gly Thr 
    2420                 2425                 2430             


Ser Thr  Gly Gly Arg Gln Gly  Ser His His Lys Gln  Ala Arg Asp 
    2435                 2440                 2445             


Ser Ser  Arg His Ser Thr Ser  Gln Glu Gly Gln Asp  Thr Ile His 
    2450                 2455                 2460             


Gly His  Pro Gly Ser Ser Ser  Gly Gly Arg Gln Gly  Ser His Tyr 
    2465                 2470                 2475             


Glu Gln  Leu Val Asp Arg Ser  Gly His Ser Gly Ser  His His Ser 
    2480                 2485                 2490             


His Thr  Thr Ser Gln Gly Arg  Ser Asp Ala Ser His  Gly His Ser 
    2495                 2500                 2505             


Gly Ser  Arg Ser Ala Ser Arg  Gln Thr Arg Asn Asp  Glu Gln Ser 
    2510                 2515                 2520             


Gly Asp  Gly Ser Arg His Ser  Gly Ser Arg His His  Glu Ala Ser 
    2525                 2530                 2535             


Ser Arg  Ala Asp Ser Ser Gly  His Ser Gln Val Gly  Gln Gly Gln 
    2540                 2545                 2550             


Ser Glu  Gly Pro Arg Thr Ser  Arg Asn Trp Gly Ser  Ser Phe Ser 
    2555                 2560                 2565             


Gln Asp  Ser Asp Ser Gln Gly  His Ser Glu Asp Ser  Glu Arg Trp 
    2570                 2575                 2580             


Ser Gly  Ser Ala Ser Arg Asn  His His Gly Ser Ala  Gln Glu Gln 
    2585                 2590                 2595             


Leu Arg  Asp Gly Ser Arg His  Pro Arg Ser His Gln  Glu Asp Arg 
    2600                 2605                 2610             


Ala Gly  His Gly His Ser Ala  Asp Ser Ser Arg Gln  Ser Gly Thr 
    2615                 2620                 2625             


Arg His  Thr Gln Thr Ser Ser  Gly Gly Gln Ala Ala  Ser Ser His 
    2630                 2635                 2640             


Glu Gln  Ala Arg Ser Ser Ala  Gly Glu Arg His Gly  Ser His His 
    2645                 2650                 2655             


Gln Gln  Ser Ala Asp Ser Ser  Arg His Ser Gly Ile  Gly His Gly 
    2660                 2665                 2670             


Gln Ala  Ser Ser Ala Val Arg  Asp Ser Gly His Arg  Gly Tyr Ser 
    2675                 2680                 2685             


Gly Ser  Gln Ala Ser Asp Asn  Glu Gly His Ser Glu  Asp Ser Asp 
    2690                 2695                 2700             


Thr Gln  Ser Val Ser Ala His  Gly Gln Ala Gly Ser  His Gln Gln 
    2705                 2710                 2715             


Ser His  Gln Glu Ser Ala Arg  Gly Arg Ser Gly Glu  Thr Ser Gly 
    2720                 2725                 2730             


His Ser  Gly Ser Phe Leu Tyr  Gln Val Ser Thr His  Glu Gln Ser 
    2735                 2740                 2745             


Glu Ser  Ser His Gly Trp Thr  Gly Pro Ser Thr Arg  Gly Arg Gln 
    2750                 2755                 2760             


Gly Ser  Arg His Glu Gln Ala  Gln Asp Ser Ser Arg  His Ser Ala 
    2765                 2770                 2775             


Ser Gln  Asp Gly Gln Asp Thr  Ile Arg Gly His Pro  Gly Ser Ser 
    2780                 2785                 2790             


Arg Gly  Gly Arg Gln Gly Tyr  His His Glu His Ser  Val Asp Ser 
    2795                 2800                 2805             


Ser Gly  His Ser Gly Ser His  His Ser His Thr Thr  Ser Gln Gly 
    2810                 2815                 2820             


Arg Ser  Asp Ala Ser Arg Gly  Gln Ser Gly Ser Arg  Ser Ala Ser 
    2825                 2830                 2835             


Arg Thr  Thr Arg Asn Glu Glu  Gln Ser Gly Asp Gly  Ser Arg His 
    2840                 2845                 2850             


Ser Gly  Ser Arg His His Glu  Ala Ser Thr His Ala  Asp Ile Ser 
    2855                 2860                 2865             


Arg His  Ser Gln Ala Val Gln  Gly Gln Ser Glu Gly  Ser Arg Arg 
    2870                 2875                 2880             


Ser Arg  Arg Gln Gly Ser Ser  Val Ser Gln Asp Ser  Asp Ser Glu 
    2885                 2890                 2895             


Gly His  Ser Glu Asp Ser Glu  Arg Trp Ser Gly Ser  Ala Ser Arg 
    2900                 2905                 2910             


Asn His  His Gly Ser Ala Gln  Glu Gln Leu Arg Asp  Gly Ser Arg 
    2915                 2920                 2925             


His Pro  Arg Ser His Gln Glu  Asp Arg Ala Gly His  Gly His Ser 
    2930                 2935                 2940             


Ala Asp  Ser Ser Arg Gln Ser  Gly Thr Arg His Thr  Gln Thr Ser 
    2945                 2950                 2955             


Ser Gly  Gly Gln Ala Ala Ser  Ser His Glu Gln Ala  Arg Ser Ser 
    2960                 2965                 2970             


Ala Gly  Glu Arg His Gly Ser  His His Gln Gln Ser  Ala Asp Ser 
    2975                 2980                 2985             


Ser Arg  His Ser Gly Ile Gly  His Gly Gln Ala Ser  Ser Ala Val 
    2990                 2995                 3000             


Arg Asp  Ser Gly His Arg Gly  Tyr Ser Gly Ser Gln  Ala Ser Asp 
    3005                 3010                 3015             


Asn Glu  Gly His Ser Glu Asp  Ser Asp Thr Gln Ser  Val Ser Ala 
    3020                 3025                 3030             


His Gly  Gln Ala Gly Ser His  Gln Gln Ser His Gln  Glu Ser Ala 
    3035                 3040                 3045             


Arg Gly  Arg Ser Gly Glu Thr  Ser Gly His Ser Gly  Ser Phe Leu 
    3050                 3055                 3060             


Tyr Gln  Val Ser Thr His Glu  Gln Ser Glu Ser Ser  His Gly Trp 
    3065                 3070                 3075             


Thr Gly  Pro Ser Thr Arg Gly  Arg Gln Gly Ser Arg  His Glu Gln 
    3080                 3085                 3090             


Ala Gln  Asp Ser Ser Arg His  Ser Ala Ser Gln Tyr  Gly Gln Asp 
    3095                 3100                 3105             


Thr Ile  Arg Gly His Pro Gly  Ser Ser Arg Gly Gly  Arg Gln Gly 
    3110                 3115                 3120             


Tyr His  His Glu His Ser Val  Asp Ser Ser Gly His  Ser Gly Ser 
    3125                 3130                 3135             


His His  Ser His Thr Thr Ser  Gln Gly Arg Ser Asp  Ala Ser Arg 
    3140                 3145                 3150             


Gly Gln  Ser Gly Ser Arg Ser  Ala Ser Arg Thr Thr  Arg Asn Glu 
    3155                 3160                 3165             


Glu Gln  Ser Gly Asp Ser Ser  Arg His Ser Val Ser  Arg His His 
    3170                 3175                 3180             


Glu Ala  Ser Thr His Ala Asp  Ile Ser Arg His Ser  Gln Ala Val 
    3185                 3190                 3195             


Gln Gly  Gln Ser Glu Gly Ser  Arg Arg Ser Arg Arg  Gln Gly Ser 
    3200                 3205                 3210             


Ser Val  Ser Gln Asp Ser Asp  Ser Glu Gly His Ser  Glu Asp Ser 
    3215                 3220                 3225             


Glu Arg  Trp Ser Gly Ser Ala  Ser Arg Asn His Arg  Gly Ser Val 
    3230                 3235                 3240             


Gln Glu  Gln Ser Arg His Gly  Ser Arg His Pro Arg  Ser His His 
    3245                 3250                 3255             


Glu Asp  Arg Ala Gly His Gly  His Ser Ala Asp Arg  Ser Arg Gln 
    3260                 3265                 3270             


Ser Gly  Thr Arg His Ala Glu  Thr Ser Ser Gly Gly  Gln Ala Ala 
    3275                 3280                 3285             


Ser Ser  His Glu Gln Ala Arg  Ser Ser Pro Gly Glu  Arg His Gly 
    3290                 3295                 3300             


Ser Arg  His Gln Gln Ser Ala  Asp Ser Ser Arg His  Ser Gly Ile 
    3305                 3310                 3315             


Pro Arg  Gly Gln Ala Ser Ser  Ala Val Arg Asp Ser  Arg His Trp 
    3320                 3325                 3330             


Gly Ser  Ser Gly Ser Gln Ala  Ser Asp Ser Glu Gly  His Ser Glu 
    3335                 3340                 3345             


Glu Ser  Asp Thr Gln Ser Val  Ser Gly His Gly Gln  Ala Gly Pro 
    3350                 3355                 3360             


His Gln  Gln Ser His Gln Glu  Ser Ala Arg Asp Arg  Ser Gly Gly 
    3365                 3370                 3375             


Arg Ser  Gly Arg Ser Gly Ser  Phe Leu Tyr Gln Val  Ser Thr His 
    3380                 3385                 3390             


Glu Gln  Ser Glu Ser Ala His  Gly Arg Thr Arg Thr  Ser Thr Gly 
    3395                 3400                 3405             


Arg Arg  Gln Gly Ser His His  Glu Gln Ala Arg Asp  Ser Ser Arg 
    3410                 3415                 3420             


His Ser  Ala Ser Gln Glu Gly  Gln Asp Thr Ile Arg  Gly His Pro 
    3425                 3430                 3435             


Gly Ser  Ser Arg Arg Gly Arg  Gln Gly Ser His Tyr  Glu Gln Ser 
    3440                 3445                 3450             


Val Asp  Arg Ser Gly His Ser  Gly Ser His His Ser  His Thr Thr 
    3455                 3460                 3465             


Ser Gln  Gly Arg Ser Asp Ala  Ser Arg Gly Gln Ser  Gly Ser Arg 
    3470                 3475                 3480             


Ser Ala  Ser Arg Gln Thr Arg  Asn Asp Glu Gln Ser  Gly Asp Gly 
    3485                 3490                 3495             


Ser Arg  His Ser Trp Ser His  His His Glu Ala Ser  Thr Gln Ala 
    3500                 3505                 3510             


Asp Ser  Ser Arg His Ser Gln  Ser Gly Gln Gly Gln  Ser Ala Gly 
    3515                 3520                 3525             


Pro Arg  Thr Ser Arg Asn Gln  Gly Ser Ser Val Ser  Gln Asp Ser 
    3530                 3535                 3540             


Asp Ser  Gln Gly His Ser Glu  Asp Ser Glu Arg Trp  Ser Gly Ser 
    3545                 3550                 3555             


Ala Ser  Arg Asn His Arg Gly  Ser Ala Gln Glu Gln  Ser Arg Asp 
    3560                 3565                 3570             


Gly Ser  Arg His Pro Thr Ser  His His Glu Asp Arg  Ala Gly His 
    3575                 3580                 3585             


Gly His  Ser Ala Glu Ser Ser  Arg Gln Ser Gly Thr  His His Ala 
    3590                 3595                 3600             


Glu Asn  Ser Ser Gly Gly Gln  Ala Ala Ser Ser His  Glu Gln Ala 
    3605                 3610                 3615             


Arg Ser  Ser Ala Gly Glu Arg  His Gly Ser His His  Gln Gln Ser 
    3620                 3625                 3630             


Ala Asp  Ser Ser Arg His Ser  Gly Ile Gly His Gly  Gln Ala Ser 
    3635                 3640                 3645             


Ser Ala  Val Arg Asp Ser Gly  His Arg Gly Ser Ser  Gly Ser Gln 
    3650                 3655                 3660             


Ala Ser  Asp Ser Glu Gly His  Ser Glu Asp Ser Asp  Thr Gln Ser 
    3665                 3670                 3675             


Val Ser  Ala His Gly Gln Ala  Gly Pro His Gln Gln  Ser His Gln 
    3680                 3685                 3690             


Glu Ser  Thr Arg Gly Arg Ser  Ala Gly Arg Ser Gly  Arg Ser Gly 
    3695                 3700                 3705             


Ser Phe  Leu Tyr Gln Val Ser  Thr His Glu Gln Ser  Glu Ser Ala 
    3710                 3715                 3720             


His Gly  Arg Ala Gly Pro Ser  Thr Gly Gly Arg Gln  Gly Ser Arg 
    3725                 3730                 3735             


His Glu  Gln Ala Arg Asp Ser  Ser Arg His Ser Ala  Ser Gln Glu 
    3740                 3745                 3750             


Gly Gln  Asp Thr Ile Arg Gly  His Pro Gly Ser Arg  Arg Gly Gly 
    3755                 3760                 3765             


Arg Gln  Gly Ser Tyr His Glu  Gln Ser Val Asp Arg  Ser Gly His 
    3770                 3775                 3780             


Ser Gly  Ser His His Ser His  Thr Thr Ser Gln Gly  Arg Ser Asp 
    3785                 3790                 3795             


Ala Ser  His Gly Gln Ser Gly  Ser Arg Ser Ala Ser  Arg Glu Thr 
    3800                 3805                 3810             


Arg Asn  Glu Glu Gln Ser Gly  Asp Gly Ser Arg His  Ser Gly Ser 
    3815                 3820                 3825             


Arg His  His Glu Ala Ser Thr  Gln Ala Asp Ser Ser  Arg His Ser 
    3830                 3835                 3840             


Gln Ser  Gly Gln Gly Glu Ser  Ala Gly Ser Arg Arg  Ser Arg Arg 
    3845                 3850                 3855             


Gln Gly  Ser Ser Val Ser Gln  Asp Ser Asp Ser Glu  Ala Tyr Pro 
    3860                 3865                 3870             


Glu Asp  Ser Glu Arg Arg Ser  Glu Ser Ala Ser Arg  Asn His His 
    3875                 3880                 3885             


Gly Ser  Ser Arg Glu Gln Ser  Arg Asp Gly Ser Arg  His Pro Gly 
    3890                 3895                 3900             


Ser Ser  His Arg Asp Thr Ala  Ser His Val Gln Ser  Ser Pro Val 
    3905                 3910                 3915             


Gln Ser  Asp Ser Ser Thr Ala  Lys Glu His Gly His  Phe Ser Ser 
    3920                 3925                 3930             


Leu Ser  Gln Asp Ser Ala Tyr  His Ser Gly Ile Gln  Ser Arg Gly 
    3935                 3940                 3945             


Ser Pro  His Ser Ser Ser Ser  Tyr His Tyr Gln Ser  Glu Gly Thr 
    3950                 3955                 3960             


Glu Arg  Gln Lys Gly Gln Ser  Gly Leu Val Trp Arg  His Gly Ser 
    3965                 3970                 3975             


Tyr Gly  Ser Ala Asp Tyr Asp  Tyr Gly Glu Ser Gly  Phe Arg His 
    3980                 3985                 3990             


Ser Gln  His Gly Ser Val Ser  Tyr Asn Ser Asn Pro  Val Val Phe 
    3995                 4000                 4005             


Lys Glu  Arg Ser Asp Ile Cys  Lys Ala Ser Ala Phe  Gly Lys Asp 
    4010                 4015                 4020             


His Pro  Arg Tyr Tyr Ala Thr  Tyr Ile Asn Lys Asp  Pro Gly Leu 
    4025                 4030                 4035             


Cys Gly  His Ser Ser Asp Ile  Ser Lys Gln Leu Gly  Phe Ser Gln 
    4040                 4045                 4050             


Ser Gln  Arg Tyr Tyr Tyr Tyr  Glu 
    4055                 4060     


<210>  4087
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLI1__Homo_sapiens__NP_001257939

<400>  4087

Met Glu Gly Gly Leu Ala Gly Glu Arg Ala Arg Glu Ser Pro Val Asp 
1               5                   10                  15      


Cys Ser Val Ser Lys Cys Ser Lys Leu Val Gly Gly Gly Glu Ser Asn 
            20                  25                  30          


Pro Met Asn Tyr Asn Ser Tyr Met Asp Glu Lys Asn Gly Pro Pro Pro 
        35                  40                  45              


Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val Pro Ala Asp Pro 
    50                  55                  60                  


Thr Leu Trp Thr Gln Glu His Val Arg Gln Trp Leu Glu Trp Ala Ile 
65                  70                  75                  80  


Lys Glu Tyr Ser Leu Met Glu Ile Asp Thr Ser Phe Phe Gln Asn Met 
                85                  90                  95      


Asp Gly Lys Glu Leu Cys Lys Met Asn Lys Glu Asp Phe Leu Arg Ala 
            100                 105                 110         


Thr Thr Leu Tyr Asn Thr Glu Val Leu Leu Ser His Leu Ser Tyr Leu 
        115                 120                 125             


Arg Glu Ser Ser Leu Leu Ala Tyr Asn Thr Thr Ser His Thr Asp Gln 
    130                 135                 140                 


Ser Ser Arg Leu Ser Val Lys Glu Asp Pro Ser Tyr Asp Ser Val Arg 
145                 150                 155                 160 


Arg Gly Ala Trp Gly Asn Asn Met Asn Ser Gly Leu Asn Lys Ser Pro 
                165                 170                 175     


Pro Leu Gly Gly Ala Gln Thr Ile Ser Lys Asn Thr Glu Gln Arg Pro 
            180                 185                 190         


Gln Pro Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala 
        195                 200                 205             


Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu 
    210                 215                 220                 


Leu Ser Asp Ser Ala Asn Ala Ser Cys Ile Thr Trp Glu Gly Thr Asn 
225                 230                 235                 240 


Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly 
                245                 250                 255     


Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala 
            260                 265                 270         


Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys 
        275                 280                 285             


Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln 
    290                 295                 300                 


Pro His Pro Thr Glu Ser Ser Met Tyr Lys Tyr Pro Ser Asp Ile Ser 
305                 310                 315                 320 


Tyr Met Pro Ser Tyr His Ala His Gln Gln Lys Val Asn Phe Val Pro 
                325                 330                 335     


Pro His Pro Ser Ser Met Pro Val Thr Ser Ser Ser Phe Phe Gly Ala 
            340                 345                 350         


Ala Ser Gln Tyr Trp Thr Ser Pro Thr Gly Gly Ile Tyr Pro Asn Pro 
        355                 360                 365             


Asn Val Pro Arg His Pro Asn Thr His Val Pro Ser His Leu Gly Ser 
    370                 375                 380                 


Tyr Tyr 
385     


<210>  4088
<211>  1214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLII__Homo_sapiens__NP_001243194

<400>  4088

Met Glu Ala Thr Gly Val Leu Pro Phe Val Arg Gly Val Asp Leu Ser 
1               5                   10                  15      


Gly Asn Asp Phe Lys Gly Gly Tyr Phe Pro Glu Asn Val Lys Ala Met 
            20                  25                  30          


Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr Gly Leu Cys Tyr Leu 
        35                  40                  45              


Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu His Leu Ser Val Ser 
    50                  55                  60                  


His Asn Asn Leu Thr Thr Leu His Gly Glu Leu Ser Ser Leu Pro Ser 
65                  70                  75                  80  


Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu Lys Asn Ser Gly Val 
                85                  90                  95      


Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser Val Leu Asp Leu Ser 
            100                 105                 110         


His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu Glu Asn Ala Lys Asn 
        115                 120                 125             


Met Leu Val Leu Asn Leu Ser His Asn Arg Gln Leu Pro Ala Met Thr 
    130                 135                 140                 


Ala Leu Gln Thr Leu His Leu Arg Ser Thr Gln Arg Thr Gln Ser Asn 
145                 150                 155                 160 


Leu Pro Thr Ser Leu Glu Gly Leu Ser Asn Leu Ala Asp Val Asp Leu 
                165                 170                 175     


Ser Cys Asn Asp Leu Thr Arg Val Pro Glu Cys Leu Tyr Thr Leu Pro 
            180                 185                 190         


Ser Leu Arg Arg Leu Asn Leu Ser Ser Asn Gln Ile Thr Glu Leu Ser 
        195                 200                 205             


Leu Cys Ile Asp Gln Trp Val His Val Glu Thr Leu Asn Leu Ser Arg 
    210                 215                 220                 


Asn Gln Leu Thr Ser Leu Pro Ser Ala Ile Cys Lys Leu Ser Lys Leu 
225                 230                 235                 240 


Lys Lys Leu Tyr Leu Asn Ser Asn Lys Leu Asp Phe Asp Gly Leu Pro 
                245                 250                 255     


Ser Gly Ile Gly Lys Leu Thr Asn Leu Glu Glu Phe Met Ala Ala Asn 
            260                 265                 270         


Asn Asn Leu Glu Leu Val Pro Glu Ser Leu Cys Arg Cys Pro Lys Leu 
        275                 280                 285             


Arg Lys Leu Val Leu Asn Lys Asn His Leu Val Thr Leu Pro Glu Ala 
    290                 295                 300                 


Ile His Phe Leu Thr Glu Ile Glu Val Leu Asp Val Arg Glu Asn Pro 
305                 310                 315                 320 


Asn Leu Val Met Pro Pro Lys Pro Ala Asp Arg Ala Ala Glu Trp Tyr 
                325                 330                 335     


Asn Ile Asp Phe Ser Leu Gln Asn Gln Leu Arg Leu Ala Gly Ala Ser 
            340                 345                 350         


Pro Ala Thr Val Ala Ala Ala Ala Ala Gly Ser Gly Pro Lys Asp Pro 
        355                 360                 365             


Met Ala Arg Lys Met Arg Leu Arg Arg Arg Lys Asp Ser Ala Gln Asp 
    370                 375                 380                 


Asp Gln Ala Lys Gln Val Leu Lys Gly Met Ser Asp Val Ala Gln Glu 
385                 390                 395                 400 


Lys Asn Lys Lys Gln Glu Glu Ser Ala Asp Ala Arg Ala Pro Ser Gly 
                405                 410                 415     


Lys Val Arg Arg Trp Asp Gln Gly Leu Glu Lys Pro Arg Leu Asp Tyr 
            420                 425                 430         


Ser Glu Phe Phe Thr Glu Asp Val Gly Gln Leu Pro Gly Leu Thr Ile 
        435                 440                 445             


Trp Gln Ile Glu Asn Phe Val Pro Val Leu Val Glu Glu Ala Phe His 
    450                 455                 460                 


Gly Lys Phe Tyr Glu Ala Asp Cys Tyr Ile Val Leu Lys Thr Phe Leu 
465                 470                 475                 480 


Asp Asp Ser Gly Ser Leu Asn Trp Glu Ile Tyr Tyr Trp Ile Gly Gly 
                485                 490                 495     


Glu Ala Thr Leu Asp Lys Lys Ala Cys Ser Ala Ile His Ala Val Asn 
            500                 505                 510         


Leu Arg Asn Tyr Leu Gly Ala Glu Cys Arg Thr Val Arg Glu Glu Met 
        515                 520                 525             


Gly Asp Glu Ser Glu Glu Phe Leu Gln Val Phe Asp Asn Asp Ile Ser 
    530                 535                 540                 


Tyr Ile Glu Gly Gly Thr Ala Ser Gly Phe Tyr Thr Val Glu Asp Thr 
545                 550                 555                 560 


His Tyr Val Thr Arg Met Tyr Arg Val Tyr Gly Lys Lys Asn Ile Lys 
                565                 570                 575     


Leu Glu Pro Val Pro Leu Lys Gly Thr Ser Leu Asp Pro Arg Phe Val 
            580                 585                 590         


Phe Leu Leu Asp Arg Gly Leu Asp Ile Tyr Val Trp Arg Gly Ala Gln 
        595                 600                 605             


Ala Thr Leu Ser Ser Thr Thr Lys Ala Arg Leu Phe Ala Glu Lys Ile 
    610                 615                 620                 


Asn Lys Asn Glu Arg Lys Gly Lys Ala Glu Ile Thr Leu Leu Val Gln 
625                 630                 635                 640 


Gly Gln Glu Leu Pro Glu Phe Trp Glu Ala Leu Gly Gly Glu Pro Ser 
                645                 650                 655     


Glu Ile Lys Lys His Val Pro Glu Asp Phe Trp Pro Pro Gln Pro Lys 
            660                 665                 670         


Leu Tyr Lys Val Gly Leu Gly Leu Gly Tyr Leu Glu Leu Pro Gln Ile 
        675                 680                 685             


Asn Tyr Lys Leu Ser Val Glu His Lys Gln Arg Pro Lys Val Glu Leu 
    690                 695                 700                 


Met Pro Arg Met Arg Leu Leu Gln Ser Leu Leu Asp Thr Arg Cys Val 
705                 710                 715                 720 


Tyr Ile Leu Asp Cys Trp Ser Asp Val Phe Ile Trp Leu Gly Arg Lys 
                725                 730                 735     


Ser Pro Arg Leu Val Arg Ala Ala Ala Leu Lys Leu Gly Gln Glu Leu 
            740                 745                 750         


Cys Gly Met Leu His Arg Pro Arg His Ala Thr Val Ser Arg Ser Leu 
        755                 760                 765             


Glu Gly Thr Glu Ala Gln Val Phe Lys Ala Lys Phe Lys Asn Trp Asp 
    770                 775                 780                 


Asp Val Leu Thr Val Asp Tyr Thr Arg Asn Ala Glu Ala Val Leu Gln 
785                 790                 795                 800 


Ser Pro Gly Leu Ser Gly Lys Val Lys Arg Asp Ala Glu Lys Lys Asp 
                805                 810                 815     


Gln Met Lys Ala Asp Leu Thr Ala Leu Phe Leu Pro Arg Gln Pro Pro 
            820                 825                 830         


Met Ser Leu Ala Glu Ala Glu Gln Leu Met Glu Glu Trp Asn Glu Asp 
        835                 840                 845             


Leu Asp Gly Met Glu Gly Phe Val Leu Glu Gly Lys Lys Phe Ala Arg 
    850                 855                 860                 


Leu Pro Glu Glu Glu Phe Gly His Phe Tyr Thr Gln Asp Cys Tyr Val 
865                 870                 875                 880 


Phe Leu Cys Arg Tyr Trp Val Pro Val Glu Tyr Glu Glu Glu Glu Lys 
                885                 890                 895     


Lys Glu Asp Lys Glu Glu Lys Ala Glu Gly Lys Glu Gly Glu Glu Ala 
            900                 905                 910         


Thr Ala Glu Ala Glu Glu Lys Gln Pro Glu Glu Asp Phe Gln Cys Ile 
        915                 920                 925             


Val Tyr Phe Trp Gln Gly Arg Glu Ala Ser Asn Met Gly Trp Leu Thr 
    930                 935                 940                 


Phe Thr Phe Ser Leu Gln Lys Lys Phe Glu Ser Leu Phe Pro Gly Lys 
945                 950                 955                 960 


Leu Glu Val Val Arg Met Thr Gln Gln Gln Glu Asn Pro Lys Phe Leu 
                965                 970                 975     


Ser His Phe Lys Arg Lys Phe Ile Ile His Arg Gly Lys Arg Lys Ala 
            980                 985                 990         


Val Gln Gly Ala Gln Gln Pro Ser  Leu Tyr Gln Ile Arg  Thr Asn Gly 
        995                 1000                 1005             


Ser Ala  Leu Cys Thr Arg Cys  Ile Gln Ile Asn Thr  Asp Ser Ser 
    1010                 1015                 1020             


Leu Leu  Asn Ser Glu Phe Cys  Phe Ile Leu Lys Val  Pro Phe Glu 
    1025                 1030                 1035             


Ser Glu  Asp Asn Gln Gly Ile  Val Tyr Ala Trp Val  Gly Arg Ala 
    1040                 1045                 1050             


Ser Asp  Pro Asp Glu Ala Lys  Leu Ala Glu Asp Ile  Leu Asn Thr 
    1055                 1060                 1065             


Met Phe  Asp Thr Ser Tyr Ser  Lys Gln Val Ile Asn  Glu Gly Glu 
    1070                 1075                 1080             


Glu Pro  Glu Asn Phe Phe Trp  Val Gly Ile Gly Ala  Gln Lys Pro 
    1085                 1090                 1095             


Tyr Asp  Asp Asp Ala Glu Tyr  Met Lys His Thr Arg  Leu Phe Arg 
    1100                 1105                 1110             


Cys Ser  Asn Glu Lys Gly Tyr  Phe Ala Val Thr Glu  Lys Cys Ser 
    1115                 1120                 1125             


Asp Phe  Cys Gln Asp Asp Leu  Ala Asp Asp Asp Ile  Met Leu Leu 
    1130                 1135                 1140             


Asp Asn  Gly Gln Glu Val Tyr  Met Trp Val Gly Thr  Gln Thr Ser 
    1145                 1150                 1155             


Gln Val  Glu Ile Lys Leu Ser  Leu Lys Ala Cys Gln  Val Tyr Ile 
    1160                 1165                 1170             


Gln His  Met Arg Ser Lys Glu  His Glu Arg Pro Arg  Arg Leu Arg 
    1175                 1180                 1185             


Leu Val  Arg Lys Gly Asn Glu  Gln His Ala Phe Thr  Arg Cys Phe 
    1190                 1195                 1200             


His Ala  Trp Ser Ala Phe Cys  Lys Ala Leu Ala 
    1205                 1210                 


<210>  4089
<211>  2647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLNA__Homo_sapiens__NP_001104026

<400>  4089

Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      


Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          


Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              


Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  


Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      


Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         


Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 


Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     


Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         


Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             


Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 


Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 


Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     


Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         


Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             


Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 


Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 


Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     


Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         


Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 


Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     


Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         


Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             


Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 


Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 


Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     


Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         


Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             


Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 


Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 


Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     


Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         


Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             


Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 


Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 


Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     


Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         


Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             


Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 


Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 


Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     


Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         


Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             


Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 


Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 


Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     


Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         


Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             


Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 


Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 


Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     


Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         


Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             


His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 


Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 


Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     


Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         


Val Lys Ser Lys Gly Ala Gly Gly  Gln Gly Lys Val Ala  Ser Lys Ile 
        995                 1000                 1005             


Val Gly  Pro Ser Gly Ala Ala  Val Pro Cys Lys Val  Glu Pro Gly 
    1010                 1015                 1020             


Leu Gly  Ala Asp Asn Ser Val  Val Arg Phe Leu Pro  Arg Glu Glu 
    1025                 1030                 1035             


Gly Pro  Tyr Glu Val Glu Val  Thr Tyr Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Gly Ser  Pro Phe Pro Leu Glu  Ala Val Ala Pro Thr  Lys Pro Ser 
    1055                 1060                 1065             


Lys Val  Lys Ala Phe Gly Pro  Gly Leu Gln Gly Gly  Ser Ala Gly 
    1070                 1075                 1080             


Ser Pro  Ala Arg Phe Thr Ile  Asp Thr Lys Gly Ala  Gly Thr Gly 
    1085                 1090                 1095             


Gly Leu  Gly Leu Thr Val Glu  Gly Pro Cys Glu Ala  Gln Leu Glu 
    1100                 1105                 1110             


Cys Leu  Asp Asn Gly Asp Gly  Thr Cys Ser Val Ser  Tyr Val Pro 
    1115                 1120                 1125             


Thr Glu  Pro Gly Asp Tyr Asn  Ile Asn Ile Leu Phe  Ala Asp Thr 
    1130                 1135                 1140             


His Ile  Pro Gly Ser Pro Phe  Lys Ala His Val Val  Pro Cys Phe 
    1145                 1150                 1155             


Asp Ala  Ser Lys Val Lys Cys  Ser Gly Pro Gly Leu  Glu Arg Ala 
    1160                 1165                 1170             


Thr Ala  Gly Glu Val Gly Gln  Phe Gln Val Asp Cys  Ser Ser Ala 
    1175                 1180                 1185             


Gly Ser  Ala Glu Leu Thr Ile  Glu Ile Cys Ser Glu  Ala Gly Leu 
    1190                 1195                 1200             


Pro Ala  Glu Val Tyr Ile Gln  Asp His Gly Asp Gly  Thr His Thr 
    1205                 1210                 1215             


Ile Thr  Tyr Ile Pro Leu Cys  Pro Gly Ala Tyr Thr  Val Thr Ile 
    1220                 1225                 1230             


Lys Tyr  Gly Gly Gln Pro Val  Pro Asn Phe Pro Ser  Lys Leu Gln 
    1235                 1240                 1245             


Val Glu  Pro Ala Val Asp Thr  Ser Gly Val Gln Cys  Tyr Gly Pro 
    1250                 1255                 1260             


Gly Ile  Glu Gly Gln Gly Val  Phe Arg Glu Ala Thr  Thr Glu Phe 
    1265                 1270                 1275             


Ser Val  Asp Ala Arg Ala Leu  Thr Gln Thr Gly Gly  Pro His Val 
    1280                 1285                 1290             


Lys Ala  Arg Val Ala Asn Pro  Ser Gly Asn Leu Thr  Glu Thr Tyr 
    1295                 1300                 1305             


Val Gln  Asp Arg Gly Asp Gly  Met Tyr Lys Val Glu  Tyr Thr Pro 
    1310                 1315                 1320             


Tyr Glu  Glu Gly Leu His Ser  Val Asp Val Thr Tyr  Asp Gly Ser 
    1325                 1330                 1335             


Pro Val  Pro Ser Ser Pro Phe  Gln Val Pro Val Thr  Glu Gly Cys 
    1340                 1345                 1350             


Asp Pro  Ser Arg Val Arg Val  His Gly Pro Gly Ile  Gln Ser Gly 
    1355                 1360                 1365             


Thr Thr  Asn Lys Pro Asn Lys  Phe Thr Val Glu Thr  Arg Gly Ala 
    1370                 1375                 1380             


Gly Thr  Gly Gly Leu Gly Leu  Ala Val Glu Gly Pro  Ser Glu Ala 
    1385                 1390                 1395             


Lys Met  Ser Cys Met Asp Asn  Lys Asp Gly Ser Cys  Ser Val Glu 
    1400                 1405                 1410             


Tyr Ile  Pro Tyr Glu Ala Gly  Thr Tyr Ser Leu Asn  Val Thr Tyr 
    1415                 1420                 1425             


Gly Gly  His Gln Val Pro Gly  Ser Pro Phe Lys Val  Pro Val His 
    1430                 1435                 1440             


Asp Val  Thr Asp Ala Ser Lys  Val Lys Cys Ser Gly  Pro Gly Leu 
    1445                 1450                 1455             


Ser Pro  Gly Met Val Arg Ala  Asn Leu Pro Gln Ser  Phe Gln Val 
    1460                 1465                 1470             


Asp Thr  Ser Lys Ala Gly Val  Ala Pro Leu Gln Val  Lys Val Gln 
    1475                 1480                 1485             


Gly Pro  Lys Gly Leu Val Glu  Pro Val Asp Val Val  Asp Asn Ala 
    1490                 1495                 1500             


Asp Gly  Thr Gln Thr Val Asn  Tyr Val Pro Ser Arg  Glu Gly Pro 
    1505                 1510                 1515             


Tyr Ser  Ile Ser Val Leu Tyr  Gly Asp Glu Glu Val  Pro Arg Ser 
    1520                 1525                 1530             


Pro Phe  Lys Val Lys Val Leu  Pro Thr His Asp Ala  Ser Lys Val 
    1535                 1540                 1545             


Lys Ala  Ser Gly Pro Gly Leu  Asn Thr Thr Gly Val  Pro Ala Ser 
    1550                 1555                 1560             


Leu Pro  Val Glu Phe Thr Ile  Asp Ala Lys Asp Ala  Gly Glu Gly 
    1565                 1570                 1575             


Leu Leu  Ala Val Gln Ile Thr  Asp Pro Glu Gly Lys  Pro Lys Lys 
    1580                 1585                 1590             


Thr His  Ile Gln Asp Asn His  Asp Gly Thr Tyr Thr  Val Ala Tyr 
    1595                 1600                 1605             


Val Pro  Asp Val Thr Gly Arg  Tyr Thr Ile Leu Ile  Lys Tyr Gly 
    1610                 1615                 1620             


Gly Asp  Glu Ile Pro Phe Ser  Pro Tyr Arg Val Arg  Ala Val Pro 
    1625                 1630                 1635             


Thr Gly  Asp Ala Ser Lys Cys  Thr Val Thr Val Ser  Ile Gly Gly 
    1640                 1645                 1650             


His Gly  Leu Gly Ala Gly Ile  Gly Pro Thr Ile Gln  Ile Gly Glu 
    1655                 1660                 1665             


Glu Thr  Val Ile Thr Val Asp  Thr Lys Ala Ala Gly  Lys Gly Lys 
    1670                 1675                 1680             


Val Thr  Cys Thr Val Cys Thr  Pro Asp Gly Ser Glu  Val Asp Val 
    1685                 1690                 1695             


Asp Val  Val Glu Asn Glu Asp  Gly Thr Phe Asp Ile  Phe Tyr Thr 
    1700                 1705                 1710             


Ala Pro  Gln Pro Gly Lys Tyr  Val Ile Cys Val Arg  Phe Gly Gly 
    1715                 1720                 1725             


Glu His  Val Pro Asn Ser Pro  Phe Gln Val Thr Ala  Leu Ala Gly 
    1730                 1735                 1740             


Asp Gln  Pro Ser Val Gln Pro  Pro Leu Arg Ser Gln  Gln Leu Ala 
    1745                 1750                 1755             


Pro Gln  Tyr Thr Tyr Ala Gln  Gly Gly Gln Gln Thr  Trp Ala Pro 
    1760                 1765                 1770             


Glu Arg  Pro Leu Val Gly Val  Asn Gly Leu Asp Val  Thr Ser Leu 
    1775                 1780                 1785             


Arg Pro  Phe Asp Leu Val Ile  Pro Phe Thr Ile Lys  Lys Gly Glu 
    1790                 1795                 1800             


Ile Thr  Gly Glu Val Arg Met  Pro Ser Gly Lys Val  Ala Gln Pro 
    1805                 1810                 1815             


Thr Ile  Thr Asp Asn Lys Asp  Gly Thr Val Thr Val  Arg Tyr Ala 
    1820                 1825                 1830             


Pro Ser  Glu Ala Gly Leu His  Glu Met Asp Ile Arg  Tyr Asp Asn 
    1835                 1840                 1845             


Met His  Ile Pro Gly Ser Pro  Leu Gln Phe Tyr Val  Asp Tyr Val 
    1850                 1855                 1860             


Asn Cys  Gly His Val Thr Ala  Tyr Gly Pro Gly Leu  Thr His Gly 
    1865                 1870                 1875             


Val Val  Asn Lys Pro Ala Thr  Phe Thr Val Asn Thr  Lys Asp Ala 
    1880                 1885                 1890             


Gly Glu  Gly Gly Leu Ser Leu  Ala Ile Glu Gly Pro  Ser Lys Ala 
    1895                 1900                 1905             


Glu Ile  Ser Cys Thr Asp Asn  Gln Asp Gly Thr Cys  Ser Val Ser 
    1910                 1915                 1920             


Tyr Leu  Pro Val Leu Pro Gly  Asp Tyr Ser Ile Leu  Val Lys Tyr 
    1925                 1930                 1935             


Asn Glu  Gln His Val Pro Gly  Ser Pro Phe Thr Ala  Arg Val Thr 
    1940                 1945                 1950             


Gly Asp  Asp Ser Met Arg Met  Ser His Leu Lys Val  Gly Ser Ala 
    1955                 1960                 1965             


Ala Asp  Ile Pro Ile Asn Ile  Ser Glu Thr Asp Leu  Ser Leu Leu 
    1970                 1975                 1980             


Thr Ala  Thr Val Val Pro Pro  Ser Gly Arg Glu Glu  Pro Cys Leu 
    1985                 1990                 1995             


Leu Lys  Arg Leu Arg Asn Gly  His Val Gly Ile Ser  Phe Val Pro 
    2000                 2005                 2010             


Lys Glu  Thr Gly Glu His Leu  Val His Val Lys Lys  Asn Gly Gln 
    2015                 2020                 2025             


His Val  Ala Ser Ser Pro Ile  Pro Val Val Ile Ser  Gln Ser Glu 
    2030                 2035                 2040             


Ile Gly  Asp Ala Ser Arg Val  Arg Val Ser Gly Gln  Gly Leu His 
    2045                 2050                 2055             


Glu Gly  His Thr Phe Glu Pro  Ala Glu Phe Ile Ile  Asp Thr Arg 
    2060                 2065                 2070             


Asp Ala  Gly Tyr Gly Gly Leu  Ser Leu Ser Ile Glu  Gly Pro Ser 
    2075                 2080                 2085             


Lys Val  Asp Ile Asn Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Arg 
    2090                 2095                 2100             


Val Thr  Tyr Cys Pro Thr Glu  Pro Gly Asn Tyr Ile  Ile Asn Ile 
    2105                 2110                 2115             


Lys Phe  Ala Asp Gln His Val  Pro Gly Ser Pro Phe  Ser Val Lys 
    2120                 2125                 2130             


Val Thr  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Arg Arg 
    2135                 2140                 2145             


Arg Ala  Pro Ser Val Ala Asn  Val Gly Ser His Cys  Asp Leu Ser 
    2150                 2155                 2160             


Leu Lys  Ile Pro Glu Ile Ser  Ile Gln Asp Met Thr  Ala Gln Val 
    2165                 2170                 2175             


Thr Ser  Pro Ser Gly Lys Thr  His Glu Ala Glu Ile  Val Glu Gly 
    2180                 2185                 2190             


Glu Asn  His Thr Tyr Cys Ile  Arg Phe Val Pro Ala  Glu Met Gly 
    2195                 2200                 2205             


Thr His  Thr Val Ser Val Lys  Tyr Lys Gly Gln His  Val Pro Gly 
    2210                 2215                 2220             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2225                 2230                 2235             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Ala Glu Ala 
    2240                 2245                 2250             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2255                 2260                 2265             


Gly Gly  Leu Ala Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2270                 2275                 2280             


Ser Phe  Glu Asp Arg Lys Asp  Gly Ser Cys Gly Val  Ala Tyr Val 
    2285                 2290                 2295             


Val Gln  Glu Pro Gly Asp Tyr  Glu Val Ser Val Lys  Phe Asn Glu 
    2300                 2305                 2310             


Glu His  Ile Pro Asp Ser Pro  Phe Val Val Pro Val  Ala Ser Pro 
    2315                 2320                 2325             


Ser Gly  Asp Ala Arg Arg Leu  Thr Val Ser Ser Leu  Gln Glu Ser 
    2330                 2335                 2340             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Val  Ser Leu Asn 
    2345                 2350                 2355             


Gly Ala  Lys Gly Ala Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2360                 2365                 2370             


Ala Leu  Glu Glu Cys Tyr Val  Thr Glu Ile Asp Gln  Asp Lys Tyr 
    2375                 2380                 2385             


Ala Val  Arg Phe Ile Pro Arg  Glu Asn Gly Val Tyr  Leu Ile Asp 
    2390                 2395                 2400             


Val Lys  Phe Asn Gly Thr His  Ile Pro Gly Ser Pro  Phe Lys Ile 
    2405                 2410                 2415             


Arg Val  Gly Glu Pro Gly His  Gly Gly Asp Pro Gly  Leu Val Ser 
    2420                 2425                 2430             


Ala Tyr  Gly Ala Gly Leu Glu  Gly Gly Val Thr Gly  Asn Pro Ala 
    2435                 2440                 2445             


Glu Phe  Val Val Asn Thr Ser  Asn Ala Gly Ala Gly  Ala Leu Ser 
    2450                 2455                 2460             


Val Thr  Ile Asp Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2465                 2470                 2475             


Cys Pro  Glu Gly Tyr Arg Val  Thr Tyr Thr Pro Met  Ala Pro Gly 
    2480                 2485                 2490             


Ser Tyr  Leu Ile Ser Ile Lys  Tyr Gly Gly Pro Tyr  His Ile Gly 
    2495                 2500                 2505             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Pro Arg  Leu Val Ser 
    2510                 2515                 2520             


Asn His  Ser Leu His Glu Thr  Ser Ser Val Phe Val  Asp Ser Leu 
    2525                 2530                 2535             


Thr Lys  Ala Thr Cys Ala Pro  Gln His Gly Ala Pro  Gly Pro Gly 
    2540                 2545                 2550             


Pro Ala  Asp Ala Ser Lys Val  Val Ala Lys Gly Leu  Gly Leu Ser 
    2555                 2560                 2565             


Lys Ala  Tyr Val Gly Gln Lys  Ser Ser Phe Thr Val  Asp Cys Ser 
    2570                 2575                 2580             


Lys Ala  Gly Asn Asn Met Leu  Leu Val Gly Val His  Gly Pro Arg 
    2585                 2590                 2595             


Thr Pro  Cys Glu Glu Ile Leu  Val Lys His Val Gly  Ser Arg Leu 
    2600                 2605                 2610             


Tyr Ser  Val Ser Tyr Leu Leu  Lys Asp Lys Gly Glu  Tyr Thr Leu 
    2615                 2620                 2625             


Val Val  Lys Trp Gly Asp Glu  His Ile Pro Gly Ser  Pro Tyr Arg 
    2630                 2635                 2640             


Val Val  Val Pro 
    2645         


<210>  4090
<211>  2633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLNB__Homo_sapiens__NP_001157789

<400>  4090

Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      


Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          


Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              


Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  


Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  


Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      


Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         


Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             


Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 


Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 


Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     


Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         


Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             


Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 


Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 


Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     


Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         


Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             


Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 


Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 


Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     


His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         


Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             


Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 


Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 


Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     


Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         


Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             


Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 


Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 


Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     


Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         


Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             


Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 


Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 


Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     


Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         


Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             


Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 


Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 


Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     


Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         


Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             


Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 


Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 


Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     


Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         


Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             


Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 


Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 


His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     


Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         


Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             


Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 


Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 


Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     


Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         


Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             


Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 


Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 


Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     


Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         


Val Thr Pro Val Thr Gly Arg Glu  Asn Ser Thr Ala Lys  Phe Ile Pro 
        995                 1000                 1005             


Arg Glu  Glu Gly Leu Tyr Ala  Val Asp Val Thr Tyr  Asp Gly His 
    1010                 1015                 1020             


Pro Val  Pro Gly Ser Pro Tyr  Thr Val Glu Ala Ser  Leu Pro Pro 
    1025                 1030                 1035             


Asp Pro  Ser Lys Val Lys Ala  His Gly Pro Gly Leu  Glu Gly Gly 
    1040                 1045                 1050             


Leu Val  Gly Lys Pro Ala Glu  Phe Thr Ile Asp Thr  Lys Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Leu Gly Leu  Thr Val Glu Gly Pro  Cys Glu Ala 
    1070                 1075                 1080             


Lys Ile  Glu Cys Ser Asp Asn  Gly Asp Gly Thr Cys  Ser Val Ser 
    1085                 1090                 1095             


Tyr Leu  Pro Thr Lys Pro Gly  Glu Tyr Phe Val Asn  Ile Leu Phe 
    1100                 1105                 1110             


Glu Glu  Val His Ile Pro Gly  Ser Pro Phe Lys Ala  Asp Ile Glu 
    1115                 1120                 1125             


Met Pro  Phe Asp Pro Ser Lys  Val Val Ala Ser Gly  Pro Gly Leu 
    1130                 1135                 1140             


Glu His  Gly Lys Val Gly Glu  Ala Gly Leu Leu Ser  Val Asp Cys 
    1145                 1150                 1155             


Ser Glu  Ala Gly Pro Gly Ala  Leu Gly Leu Glu Ala  Val Ser Asp 
    1160                 1165                 1170             


Ser Gly  Thr Lys Ala Glu Val  Ser Ile Gln Asn Asn  Lys Asp Gly 
    1175                 1180                 1185             


Thr Tyr  Ala Val Thr Tyr Val  Pro Leu Thr Ala Gly  Met Tyr Thr 
    1190                 1195                 1200             


Leu Thr  Met Lys Tyr Gly Gly  Glu Leu Val Pro His  Phe Pro Ala 
    1205                 1210                 1215             


Arg Val  Lys Val Glu Pro Ala  Val Asp Thr Ser Arg  Ile Lys Val 
    1220                 1225                 1230             


Phe Gly  Pro Gly Ile Glu Gly  Lys Asp Val Phe Arg  Glu Ala Thr 
    1235                 1240                 1245             


Thr Asp  Phe Thr Val Asp Ser  Arg Pro Leu Thr Gln  Val Gly Gly 
    1250                 1255                 1260             


Asp His  Ile Lys Ala His Ile  Ala Asn Pro Ser Gly  Ala Ser Thr 
    1265                 1270                 1275             


Glu Cys  Phe Val Thr Asp Asn  Ala Asp Gly Thr Tyr  Gln Val Glu 
    1280                 1285                 1290             


Tyr Thr  Pro Phe Glu Lys Gly  Leu His Val Val Glu  Val Thr Tyr 
    1295                 1300                 1305             


Asp Asp  Val Pro Ile Pro Asn  Ser Pro Phe Lys Val  Ala Val Thr 
    1310                 1315                 1320             


Glu Gly  Cys Gln Pro Ser Arg  Val Gln Ala Gln Gly  Pro Gly Leu 
    1325                 1330                 1335             


Lys Glu  Ala Phe Thr Asn Lys  Pro Asn Val Phe Thr  Val Val Thr 
    1340                 1345                 1350             


Arg Gly  Ala Gly Ile Gly Gly  Leu Gly Ile Thr Val  Glu Gly Pro 
    1355                 1360                 1365             


Ser Glu  Ser Lys Ile Asn Cys  Arg Asp Asn Lys Asp  Gly Ser Cys 
    1370                 1375                 1380             


Ser Ala  Glu Tyr Ile Pro Phe  Ala Pro Gly Asp Tyr  Asp Val Asn 
    1385                 1390                 1395             


Ile Thr  Tyr Gly Gly Ala His  Ile Pro Gly Ser Pro  Phe Arg Val 
    1400                 1405                 1410             


Pro Val  Lys Asp Val Val Asp  Pro Ser Lys Val Lys  Ile Ala Gly 
    1415                 1420                 1425             


Pro Gly  Leu Gly Ser Gly Val  Arg Ala Arg Val Leu  Gln Ser Phe 
    1430                 1435                 1440             


Thr Val  Asp Ser Ser Lys Ala  Gly Leu Ala Pro Leu  Glu Val Arg 
    1445                 1450                 1455             


Val Leu  Gly Pro Arg Ala Asp  Asp Thr Asp Ser Gln  Ser Trp Arg 
    1460                 1465                 1470             


Ser Pro  Leu Lys Ala Leu Ser  Glu Phe Phe Lys Gly  Asp Pro Lys 
    1475                 1480                 1485             


Gly Asp  Phe Asn Lys Thr Gly  Leu Val Glu Pro Val  Asn Val Val 
    1490                 1495                 1500             


Asp Asn  Gly Asp Gly Thr His  Thr Val Thr Tyr Thr  Pro Ser Gln 
    1505                 1510                 1515             


Glu Gly  Pro Tyr Met Val Ser  Val Lys Tyr Ala Asp  Glu Glu Ile 
    1520                 1525                 1530             


Pro Arg  Ser Pro Phe Lys Val  Lys Val Leu Pro Thr  Tyr Asp Ala 
    1535                 1540                 1545             


Ser Lys  Val Thr Ala Ser Gly  Pro Gly Leu Ser Ser  Tyr Gly Val 
    1550                 1555                 1560             


Pro Ala  Ser Leu Pro Val Asp  Phe Ala Ile Asp Ala  Arg Asp Ala 
    1565                 1570                 1575             


Gly Glu  Gly Leu Leu Ala Val  Gln Ile Thr Asp Gln  Glu Gly Lys 
    1580                 1585                 1590             


Pro Lys  Arg Ala Ile Val His  Asp Asn Lys Asp Gly  Thr Tyr Ala 
    1595                 1600                 1605             


Val Thr  Tyr Ile Pro Asp Lys  Thr Gly Arg Tyr Met  Ile Gly Val 
    1610                 1615                 1620             


Thr Tyr  Gly Gly Asp Asp Ile  Pro Leu Ser Pro Tyr  Arg Ile Arg 
    1625                 1630                 1635             


Ala Thr  Gln Thr Gly Asp Ala  Ser Lys Cys Leu Ala  Thr Gly Pro 
    1640                 1645                 1650             


Gly Ile  Ala Ser Thr Val Lys  Thr Gly Glu Glu Val  Gly Phe Val 
    1655                 1660                 1665             


Val Asp  Ala Lys Thr Ala Gly  Lys Gly Lys Val Thr  Cys Thr Val 
    1670                 1675                 1680             


Leu Thr  Pro Asp Gly Thr Glu  Ala Glu Ala Asp Val  Ile Glu Asn 
    1685                 1690                 1695             


Glu Asp  Gly Thr Tyr Asp Ile  Phe Tyr Thr Ala Ala  Lys Pro Gly 
    1700                 1705                 1710             


Thr Tyr  Val Ile Tyr Val Arg  Phe Gly Gly Val Asp  Ile Pro Asn 
    1715                 1720                 1725             


Ser Pro  Phe Thr Val Met Ala  Thr Asp Gly Glu Val  Thr Ala Val 
    1730                 1735                 1740             


Glu Glu  Ala Pro Val Asn Ala  Cys Pro Pro Gly Phe  Arg Pro Trp 
    1745                 1750                 1755             


Val Thr  Glu Glu Ala Tyr Val  Pro Val Ser Asp Met  Asn Gly Leu 
    1760                 1765                 1770             


Gly Phe  Lys Pro Phe Asp Leu  Val Ile Pro Phe Ala  Val Arg Lys 
    1775                 1780                 1785             


Gly Glu  Ile Thr Gly Glu Val  His Met Pro Ser Gly  Lys Thr Ala 
    1790                 1795                 1800             


Thr Pro  Glu Ile Val Asp Asn  Lys Asp Gly Thr Val  Thr Val Arg 
    1805                 1810                 1815             


Tyr Ala  Pro Thr Glu Val Gly  Leu His Glu Met His  Ile Lys Tyr 
    1820                 1825                 1830             


Met Gly  Ser His Ile Pro Glu  Ser Pro Leu Gln Phe  Tyr Val Asn 
    1835                 1840                 1845             


Tyr Pro  Asn Ser Gly Ser Val  Ser Ala Tyr Gly Pro  Gly Leu Val 
    1850                 1855                 1860             


Tyr Gly  Val Ala Asn Lys Thr  Ala Thr Phe Thr Ile  Val Thr Glu 
    1865                 1870                 1875             


Asp Ala  Gly Glu Gly Gly Leu  Asp Leu Ala Ile Glu  Gly Pro Ser 
    1880                 1885                 1890             


Lys Ala  Glu Ile Ser Cys Ile  Asp Asn Lys Asp Gly  Thr Cys Thr 
    1895                 1900                 1905             


Val Thr  Tyr Leu Pro Thr Leu  Pro Gly Asp Tyr Ser  Ile Leu Val 
    1910                 1915                 1920             


Lys Tyr  Asn Asp Lys His Ile  Pro Gly Ser Pro Phe  Thr Ala Lys 
    1925                 1930                 1935             


Ile Thr  Asp Asp Ser Arg Arg  Cys Ser Gln Val Lys  Leu Gly Ser 
    1940                 1945                 1950             


Ala Ala  Asp Phe Leu Leu Asp  Ile Ser Glu Thr Asp  Leu Ser Ser 
    1955                 1960                 1965             


Leu Thr  Ala Ser Ile Lys Ala  Pro Ser Gly Arg Asp  Glu Pro Cys 
    1970                 1975                 1980             


Leu Leu  Lys Arg Leu Pro Asn  Asn His Ile Gly Ile  Ser Phe Ile 
    1985                 1990                 1995             


Pro Arg  Glu Val Gly Glu His  Leu Val Ser Ile Lys  Lys Asn Gly 
    2000                 2005                 2010             


Asn His  Val Ala Asn Ser Pro  Val Ser Ile Met Val  Val Gln Ser 
    2015                 2020                 2025             


Glu Ile  Gly Asp Ala Arg Arg  Ala Lys Val Tyr Gly  Arg Gly Leu 
    2030                 2035                 2040             


Ser Glu  Gly Arg Thr Phe Glu  Met Ser Asp Phe Ile  Val Asp Thr 
    2045                 2050                 2055             


Arg Asp  Ala Gly Tyr Gly Gly  Ile Ser Leu Ala Val  Glu Gly Pro 
    2060                 2065                 2070             


Ser Lys  Val Asp Ile Gln Thr  Glu Asp Leu Glu Asp  Gly Thr Cys 
    2075                 2080                 2085             


Lys Val  Ser Tyr Phe Pro Thr  Val Pro Gly Val Tyr  Ile Val Ser 
    2090                 2095                 2100             


Thr Lys  Phe Ala Asp Glu His  Val Pro Gly Ser Pro  Phe Thr Val 
    2105                 2110                 2115             


Lys Ile  Ser Gly Glu Gly Arg  Val Lys Glu Ser Ile  Thr Arg Thr 
    2120                 2125                 2130             


Ser Arg  Ala Pro Ser Val Ala  Thr Val Gly Ser Ile  Cys Asp Leu 
    2135                 2140                 2145             


Asn Leu  Lys Ile Pro Glu Ile  Asn Ser Ser Asp Met  Ser Ala His 
    2150                 2155                 2160             


Val Thr  Ser Pro Ser Gly Arg  Val Thr Glu Ala Glu  Ile Val Pro 
    2165                 2170                 2175             


Met Gly  Lys Asn Ser His Cys  Val Arg Phe Val Pro  Gln Glu Met 
    2180                 2185                 2190             


Gly Val  His Thr Val Ser Val  Lys Tyr Arg Gly Gln  His Val Thr 
    2195                 2200                 2205             


Gly Ser  Pro Phe Gln Phe Thr  Val Gly Pro Leu Gly  Glu Gly Gly 
    2210                 2215                 2220             


Ala His  Lys Val Arg Ala Gly  Gly Pro Gly Leu Glu  Arg Gly Glu 
    2225                 2230                 2235             


Ala Gly  Val Pro Ala Glu Phe  Ser Ile Trp Thr Arg  Glu Ala Gly 
    2240                 2245                 2250             


Ala Gly  Gly Leu Ser Ile Ala  Val Glu Gly Pro Ser  Lys Ala Glu 
    2255                 2260                 2265             


Ile Thr  Phe Asp Asp His Lys  Asn Gly Ser Cys Gly  Val Ser Tyr 
    2270                 2275                 2280             


Ile Ala  Gln Glu Pro Gly Asn  Tyr Glu Val Ser Ile  Lys Phe Asn 
    2285                 2290                 2295             


Asp Glu  His Ile Pro Glu Ser  Pro Tyr Leu Val Pro  Val Ile Ala 
    2300                 2305                 2310             


Pro Ser  Asp Asp Ala Arg Arg  Leu Thr Val Met Ser  Leu Gln Glu 
    2315                 2320                 2325             


Ser Gly  Leu Lys Val Asn Gln  Pro Ala Ser Phe Ala  Ile Arg Leu 
    2330                 2335                 2340             


Asn Gly  Ala Lys Gly Lys Ile  Asp Ala Lys Val His  Ser Pro Ser 
    2345                 2350                 2355             


Gly Ala  Val Glu Glu Cys His  Val Ser Glu Leu Glu  Pro Asp Lys 
    2360                 2365                 2370             


Tyr Ala  Val Arg Phe Ile Pro  His Glu Asn Gly Val  His Thr Ile 
    2375                 2380                 2385             


Asp Val  Lys Phe Asn Gly Ser  His Val Val Gly Ser  Pro Phe Lys 
    2390                 2395                 2400             


Val Arg  Val Gly Glu Pro Gly  Gln Ala Gly Asn Pro  Ala Leu Val 
    2405                 2410                 2415             


Ser Ala  Tyr Gly Thr Gly Leu  Glu Gly Gly Thr Thr  Gly Ile Gln 
    2420                 2425                 2430             


Ser Glu  Phe Phe Ile Asn Thr  Thr Arg Ala Gly Pro  Gly Thr Leu 
    2435                 2440                 2445             


Ser Val  Thr Ile Glu Gly Pro  Ser Lys Val Lys Met  Asp Cys Gln 
    2450                 2455                 2460             


Glu Thr  Pro Glu Gly Tyr Lys  Val Met Tyr Thr Pro  Met Ala Pro 
    2465                 2470                 2475             


Gly Asn  Tyr Leu Ile Ser Val  Lys Tyr Gly Gly Pro  Asn His Ile 
    2480                 2485                 2490             


Val Gly  Ser Pro Phe Lys Ala  Lys Val Thr Gly Gln  Arg Leu Val 
    2495                 2500                 2505             


Ser Pro  Gly Ser Ala Asn Glu  Thr Ser Ser Ile Leu  Val Glu Ser 
    2510                 2515                 2520             


Val Thr  Arg Ser Ser Thr Glu  Thr Cys Tyr Ser Ala  Ile Pro Lys 
    2525                 2530                 2535             


Ala Ser  Ser Asp Ala Ser Lys  Val Thr Ser Lys Gly  Ala Gly Leu 
    2540                 2545                 2550             


Ser Lys  Ala Phe Val Gly Gln  Lys Ser Ser Phe Leu  Val Asp Cys 
    2555                 2560                 2565             


Ser Lys  Ala Gly Ser Asn Met  Leu Leu Ile Gly Val  His Gly Pro 
    2570                 2575                 2580             


Thr Thr  Pro Cys Glu Glu Val  Ser Met Lys His Val  Gly Asn Gln 
    2585                 2590                 2595             


Gln Tyr  Asn Val Thr Tyr Val  Val Lys Glu Arg Gly  Asp Tyr Val 
    2600                 2605                 2610             


Leu Ala  Val Lys Trp Gly Glu  Glu His Ile Pro Gly  Ser Pro Phe 
    2615                 2620                 2625             


His Val  Thr Val Pro 
    2630             


<210>  4091
<211>  2692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLNC__Homo_sapiens__NP_001120959

<400>  4091

Met Met Asn Asn Ser Gly Tyr Ser Asp Ala Gly Leu Gly Leu Gly Asp 
1               5                   10                  15      


Glu Thr Asp Glu Met Pro Ser Thr Glu Lys Asp Leu Ala Glu Asp Ala 
            20                  25                  30          


Pro Trp Lys Lys Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu 
        35                  40                  45              


His Leu Lys Cys Val Gly Lys Arg Leu Thr Asp Leu Gln Arg Asp Leu 
    50                  55                  60                  


Ser Asp Gly Leu Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys 
65                  70                  75                  80  


Arg Met Tyr Arg Lys Phe His Pro Arg Pro Asn Phe Arg Gln Met Lys 
                85                  90                  95      


Leu Glu Asn Val Ser Val Ala Leu Glu Phe Leu Glu Arg Glu His Ile 
            100                 105                 110         


Lys Leu Val Ser Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys 
        115                 120                 125             


Leu Ile Leu Gly Leu Ile Trp Thr Leu Ile Leu His Tyr Ser Ile Ser 
    130                 135                 140                 


Met Pro Met Trp Glu Asp Glu Asp Asp Glu Asp Ala Arg Lys Gln Thr 
145                 150                 155                 160 


Pro Lys Gln Arg Leu Leu Gly Trp Ile Gln Asn Lys Val Pro Gln Leu 
                165                 170                 175     


Pro Ile Thr Asn Phe Asn Arg Asp Trp Gln Asp Gly Lys Ala Leu Gly 
            180                 185                 190         


Ala Leu Val Asp Asn Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ala 
        195                 200                 205             


Trp Asp Pro Asn Gln Pro Val Glu Asn Ala Arg Glu Ala Met Gln Gln 
    210                 215                 220                 


Ala Asp Asp Trp Leu Gly Val Pro Gln Val Ile Ala Pro Glu Glu Ile 
225                 230                 235                 240 


Val Asp Pro Asn Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln 
                245                 250                 255     


Phe Pro Lys Ala Lys Leu Lys Pro Gly Ala Pro Val Arg Ser Lys Gln 
            260                 265                 270         


Leu Asn Pro Lys Lys Ala Ile Ala Tyr Gly Pro Gly Ile Glu Pro Gln 
        275                 280                 285             


Gly Asn Thr Val Leu Gln Pro Ala His Phe Thr Val Gln Thr Val Asp 
    290                 295                 300                 


Ala Gly Val Gly Glu Val Leu Val Tyr Ile Glu Asp Pro Glu Gly His 
305                 310                 315                 320 


Thr Glu Glu Ala Lys Val Val Pro Asn Asn Asp Lys Asp Arg Thr Tyr 
                325                 330                 335     


Ala Val Ser Tyr Val Pro Lys Val Ala Gly Leu His Lys Val Thr Val 
            340                 345                 350         


Leu Phe Ala Gly Gln Asn Ile Glu Arg Ser Pro Phe Glu Val Asn Val 
        355                 360                 365             


Gly Met Ala Leu Gly Asp Ala Asn Lys Val Ser Ala Arg Gly Pro Gly 
    370                 375                 380                 


Leu Glu Pro Val Gly Asn Val Ala Asn Lys Pro Thr Tyr Phe Asp Ile 
385                 390                 395                 400 


Tyr Thr Ala Gly Ala Gly Thr Gly Asp Val Ala Val Val Ile Val Asp 
                405                 410                 415     


Pro Gln Gly Arg Arg Asp Thr Val Glu Val Ala Leu Glu Asp Lys Gly 
            420                 425                 430         


Asp Ser Thr Phe Arg Cys Thr Tyr Arg Pro Ala Met Glu Gly Pro His 
        435                 440                 445             


Thr Val His Val Ala Phe Ala Gly Ala Pro Ile Thr Arg Ser Pro Phe 
    450                 455                 460                 


Pro Val His Val Ser Glu Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser 
465                 470                 475                 480 


Gly Arg Gly Leu Gln Pro Lys Gly Val Arg Val Lys Glu Val Ala Asp 
                485                 490                 495     


Phe Lys Val Phe Thr Lys Gly Ala Gly Ser Gly Glu Leu Lys Val Thr 
            500                 505                 510         


Val Lys Gly Pro Lys Gly Thr Glu Glu Pro Val Lys Val Arg Glu Ala 
        515                 520                 525             


Gly Asp Gly Val Phe Glu Cys Glu Tyr Tyr Pro Val Val Pro Gly Lys 
    530                 535                 540                 


Tyr Val Val Thr Ile Thr Trp Gly Gly Tyr Ala Ile Pro Arg Ser Pro 
545                 550                 555                 560 


Phe Glu Val Gln Val Ser Pro Glu Ala Gly Val Gln Lys Val Arg Ala 
                565                 570                 575     


Trp Gly Pro Gly Leu Glu Thr Gly Gln Val Gly Lys Ser Ala Asp Phe 
            580                 585                 590         


Val Val Glu Ala Ile Gly Thr Glu Val Gly Thr Leu Gly Phe Ser Ile 
        595                 600                 605             


Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp Asp Lys Gly Asp Gly 
    610                 615                 620                 


Ser Cys Asp Val Arg Tyr Trp Pro Thr Glu Pro Gly Glu Tyr Ala Val 
625                 630                 635                 640 


His Val Ile Cys Asp Asp Glu Asp Ile Arg Asp Ser Pro Phe Ile Ala 
                645                 650                 655     


His Ile Leu Pro Ala Pro Pro Asp Cys Phe Pro Asp Lys Val Lys Ala 
            660                 665                 670         


Phe Gly Pro Gly Leu Glu Pro Thr Gly Cys Ile Val Asp Lys Pro Ala 
        675                 680                 685             


Glu Phe Thr Ile Asp Ala Arg Ala Ala Gly Lys Gly Asp Leu Lys Leu 
    690                 695                 700                 


Tyr Ala Gln Asp Ala Asp Gly Cys Pro Ile Asp Ile Lys Val Ile Pro 
705                 710                 715                 720 


Asn Gly Asp Gly Thr Phe Arg Cys Ser Tyr Val Pro Thr Lys Pro Ile 
                725                 730                 735     


Lys His Thr Ile Ile Ile Ser Trp Gly Gly Val Asn Val Pro Lys Ser 
            740                 745                 750         


Pro Phe Arg Val Asn Val Gly Glu Gly Ser His Pro Glu Arg Val Lys 
        755                 760                 765             


Val Tyr Gly Pro Gly Val Glu Lys Thr Gly Leu Lys Ala Asn Glu Pro 
    770                 775                 780                 


Thr Tyr Phe Thr Val Asp Cys Ser Glu Ala Gly Gln Gly Asp Val Ser 
785                 790                 795                 800 


Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly Pro Ala Glu Ala Asp 
                805                 810                 815     


Ile Asp Phe Asp Ile Ile Lys Asn Asp Asn Asp Thr Phe Thr Val Lys 
            820                 825                 830         


Tyr Thr Pro Pro Gly Ala Gly Arg Tyr Thr Ile Met Val Leu Phe Ala 
        835                 840                 845             


Asn Gln Glu Ile Pro Ala Ser Pro Phe His Ile Lys Val Asp Pro Ser 
    850                 855                 860                 


His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro Gly Leu Asn Arg Thr 
865                 870                 875                 880 


Gly Val Glu Val Gly Lys Pro Thr His Phe Thr Val Leu Thr Lys Gly 
                885                 890                 895     


Ala Gly Lys Ala Lys Leu Asp Val Gln Phe Ala Gly Thr Ala Lys Gly 
            900                 905                 910         


Glu Val Val Arg Asp Phe Glu Ile Ile Asp Asn His Asp Tyr Ser Tyr 
        915                 920                 925             


Thr Val Lys Tyr Thr Ala Val Gln Gln Gly Asn Met Ala Val Thr Val 
    930                 935                 940                 


Thr Tyr Gly Gly Asp Pro Val Pro Lys Ser Pro Phe Val Val Asn Val 
945                 950                 955                 960 


Ala Pro Pro Leu Asp Leu Ser Lys Ile Lys Val Gln Gly Leu Asn Ser 
                965                 970                 975     


Lys Val Ala Val Gly Gln Glu Gln Ala Phe Ser Val Asn Thr Arg Gly 
            980                 985                 990         


Ala Gly Gly Gln Gly Gln Leu Asp  Val Arg Met Thr Ser  Pro Ser Arg 
        995                 1000                 1005             


Arg Pro  Ile Pro Cys Lys Leu  Glu Pro Gly Gly Gly  Ala Glu Ala 
    1010                 1015                 1020             


Gln Ala  Val Arg Tyr Met Pro  Pro Glu Glu Gly Pro  Tyr Lys Val 
    1025                 1030                 1035             


Asp Ile  Thr Tyr Asp Gly His  Pro Val Pro Gly Ser  Pro Phe Ala 
    1040                 1045                 1050             


Val Glu  Gly Val Leu Pro Pro  Asp Pro Ser Lys Val  Cys Ala Tyr 
    1055                 1060                 1065             


Gly Pro  Gly Leu Lys Gly Gly  Leu Val Gly Thr Pro  Ala Pro Phe 
    1070                 1075                 1080             


Ser Ile  Asp Thr Lys Gly Ala  Gly Thr Gly Gly Leu  Gly Leu Thr 
    1085                 1090                 1095             


Val Glu  Gly Pro Cys Glu Ala  Lys Ile Glu Cys Gln  Asp Asn Gly 
    1100                 1105                 1110             


Asp Gly  Ser Cys Ala Val Ser  Tyr Leu Pro Thr Glu  Pro Gly Glu 
    1115                 1120                 1125             


Tyr Thr  Ile Asn Ile Leu Phe  Ala Glu Ala His Ile  Pro Gly Ser 
    1130                 1135                 1140             


Pro Phe  Lys Ala Thr Ile Arg  Pro Val Phe Asp Pro  Ser Lys Val 
    1145                 1150                 1155             


Arg Ala  Ser Gly Pro Gly Leu  Glu Arg Gly Lys Val  Gly Glu Ala 
    1160                 1165                 1170             


Ala Thr  Phe Thr Val Asp Cys  Ser Glu Ala Gly Glu  Ala Glu Leu 
    1175                 1180                 1185             


Thr Ile  Glu Ile Leu Ser Asp  Ala Gly Val Lys Ala  Glu Val Leu 
    1190                 1195                 1200             


Ile His  Asn Asn Ala Asp Gly  Thr Tyr His Ile Thr  Tyr Ser Pro 
    1205                 1210                 1215             


Ala Phe  Pro Gly Thr Tyr Thr  Ile Thr Ile Lys Tyr  Gly Gly His 
    1220                 1225                 1230             


Pro Val  Pro Lys Phe Pro Thr  Arg Val His Val Gln  Pro Ala Val 
    1235                 1240                 1245             


Asp Thr  Ser Gly Val Lys Val  Ser Gly Pro Gly Val  Glu Pro His 
    1250                 1255                 1260             


Gly Val  Leu Arg Glu Val Thr  Thr Glu Phe Thr Val  Asp Ala Arg 
    1265                 1270                 1275             


Ser Leu  Thr Ala Thr Gly Gly  Asn His Val Thr Ala  Arg Val Leu 
    1280                 1285                 1290             


Asn Pro  Ser Gly Ala Lys Thr  Asp Thr Tyr Val Thr  Asp Asn Gly 
    1295                 1300                 1305             


Asp Gly  Thr Tyr Arg Val Gln  Tyr Thr Ala Tyr Glu  Glu Gly Val 
    1310                 1315                 1320             


His Leu  Val Glu Val Leu Tyr  Asp Glu Val Ala Val  Pro Lys Ser 
    1325                 1330                 1335             


Pro Phe  Arg Val Gly Val Thr  Glu Gly Cys Asp Pro  Thr Arg Val 
    1340                 1345                 1350             


Arg Ala  Phe Gly Pro Gly Leu  Glu Gly Gly Leu Val  Asn Lys Ala 
    1355                 1360                 1365             


Asn Arg  Phe Thr Val Glu Thr  Arg Gly Ala Gly Thr  Gly Gly Leu 
    1370                 1375                 1380             


Gly Leu  Ala Ile Glu Gly Pro  Ser Glu Ala Lys Met  Ser Cys Lys 
    1385                 1390                 1395             


Asp Asn  Lys Asp Gly Ser Cys  Thr Val Glu Tyr Ile  Pro Phe Thr 
    1400                 1405                 1410             


Pro Gly  Asp Tyr Asp Val Asn  Ile Thr Phe Gly Gly  Arg Pro Ile 
    1415                 1420                 1425             


Pro Gly  Ser Pro Phe Arg Val  Pro Val Lys Asp Val  Val Asp Pro 
    1430                 1435                 1440             


Gly Lys  Val Lys Cys Ser Gly  Pro Gly Leu Gly Ala  Gly Val Arg 
    1445                 1450                 1455             


Ala Arg  Val Pro Gln Thr Phe  Thr Val Asp Cys Ser  Gln Ala Gly 
    1460                 1465                 1470             


Arg Ala  Pro Leu Gln Val Ala  Val Leu Gly Pro Thr  Gly Val Ala 
    1475                 1480                 1485             


Glu Pro  Val Glu Val Arg Asp  Asn Gly Asp Gly Thr  His Thr Val 
    1490                 1495                 1500             


His Tyr  Thr Pro Ala Thr Asp  Gly Pro Tyr Thr Val  Ala Val Lys 
    1505                 1510                 1515             


Tyr Ala  Asp Gln Glu Val Pro  Arg Ser Pro Phe Lys  Ile Lys Val 
    1520                 1525                 1530             


Leu Pro  Ala His Asp Ala Ser  Lys Val Arg Ala Ser  Gly Pro Gly 
    1535                 1540                 1545             


Leu Asn  Ala Ser Gly Ile Pro  Ala Ser Leu Pro Val  Glu Phe Thr 
    1550                 1555                 1560             


Ile Asp  Ala Arg Asp Ala Gly  Glu Gly Leu Leu Thr  Val Gln Ile 
    1565                 1570                 1575             


Leu Asp  Pro Glu Gly Lys Pro  Lys Lys Ala Asn Ile  Arg Asp Asn 
    1580                 1585                 1590             


Gly Asp  Gly Thr Tyr Thr Val  Ser Tyr Leu Pro Asp  Met Ser Gly 
    1595                 1600                 1605             


Arg Tyr  Thr Ile Thr Ile Lys  Tyr Gly Gly Asp Glu  Ile Pro Tyr 
    1610                 1615                 1620             


Ser Pro  Phe Arg Ile His Ala  Leu Pro Thr Gly Asp  Ala Ser Lys 
    1625                 1630                 1635             


Cys Leu  Val Thr Val Ser Ile  Gly Gly His Gly Leu  Gly Ala Cys 
    1640                 1645                 1650             


Leu Gly  Pro Arg Ile Gln Ile  Gly Gln Glu Thr Val  Ile Thr Val 
    1655                 1660                 1665             


Asp Ala  Lys Ala Ala Gly Glu  Gly Lys Val Thr Cys  Thr Val Ser 
    1670                 1675                 1680             


Thr Pro  Asp Gly Ala Glu Leu  Asp Val Asp Val Val  Glu Asn His 
    1685                 1690                 1695             


Asp Gly  Thr Phe Asp Ile Tyr  Tyr Thr Ala Pro Glu  Pro Gly Lys 
    1700                 1705                 1710             


Tyr Val  Ile Thr Ile Arg Phe  Gly Gly Glu His Ile  Pro Asn Ser 
    1715                 1720                 1725             


Pro Phe  His Val Leu Ala Thr  Glu Glu Pro Val Val  Pro Val Glu 
    1730                 1735                 1740             


Pro Met  Glu Ser Met Leu Arg  Pro Phe Asn Leu Val  Ile Pro Phe 
    1745                 1750                 1755             


Ala Val  Gln Lys Gly Glu Leu  Thr Gly Glu Val Arg  Met Pro Ser 
    1760                 1765                 1770             


Gly Lys  Thr Ala Arg Pro Asn  Ile Thr Asp Asn Lys  Asp Gly Thr 
    1775                 1780                 1785             


Ile Thr  Val Arg Tyr Ala Pro  Thr Glu Lys Gly Leu  His Gln Met 
    1790                 1795                 1800             


Gly Ile  Lys Tyr Asp Gly Asn  His Ile Pro Gly Ser  Pro Leu Gln 
    1805                 1810                 1815             


Phe Tyr  Val Asp Ala Ile Asn  Ser Arg His Val Ser  Ala Tyr Gly 
    1820                 1825                 1830             


Pro Gly  Leu Ser His Gly Met  Val Asn Lys Pro Ala  Thr Phe Thr 
    1835                 1840                 1845             


Ile Val  Thr Lys Asp Ala Gly  Glu Gly Gly Leu Ser  Leu Ala Val 
    1850                 1855                 1860             


Glu Gly  Pro Ser Lys Ala Glu  Ile Thr Cys Lys Asp  Asn Lys Asp 
    1865                 1870                 1875             


Gly Thr  Cys Thr Val Ser Tyr  Leu Pro Thr Ala Pro  Gly Asp Tyr 
    1880                 1885                 1890             


Ser Ile  Ile Val Arg Phe Asp  Asp Lys His Ile Pro  Gly Ser Pro 
    1895                 1900                 1905             


Phe Thr  Ala Lys Ile Thr Gly  Asp Asp Ser Met Arg  Thr Ser Gln 
    1910                 1915                 1920             


Leu Asn  Val Gly Thr Ser Thr  Asp Val Ser Leu Lys  Ile Thr Glu 
    1925                 1930                 1935             


Ser Asp  Leu Ser Gln Leu Thr  Ala Ser Ile Arg Ala  Pro Ser Gly 
    1940                 1945                 1950             


Asn Glu  Glu Pro Cys Leu Leu  Lys Arg Leu Pro Asn  Arg His Ile 
    1955                 1960                 1965             


Gly Ile  Ser Phe Thr Pro Lys  Glu Val Gly Glu His  Val Val Ser 
    1970                 1975                 1980             


Val Arg  Lys Ser Gly Lys His  Val Thr Asn Ser Pro  Phe Lys Ile 
    1985                 1990                 1995             


Leu Val  Gly Pro Ser Glu Ile  Gly Asp Ala Ser Lys  Val Arg Val 
    2000                 2005                 2010             


Trp Gly  Lys Gly Leu Ser Glu  Gly His Thr Phe Gln  Val Ala Glu 
    2015                 2020                 2025             


Phe Ile  Val Asp Thr Arg Asn  Ala Gly Tyr Gly Gly  Leu Gly Leu 
    2030                 2035                 2040             


Ser Ile  Glu Gly Pro Ser Lys  Val Asp Ile Asn Cys  Glu Asp Met 
    2045                 2050                 2055             


Glu Asp  Gly Thr Cys Lys Val  Thr Tyr Cys Pro Thr  Glu Pro Gly 
    2060                 2065                 2070             


Thr Tyr  Ile Ile Asn Ile Lys  Phe Ala Asp Lys His  Val Pro Gly 
    2075                 2080                 2085             


Ser Pro  Phe Thr Val Lys Val  Thr Gly Glu Gly Arg  Met Lys Glu 
    2090                 2095                 2100             


Ser Ile  Thr Arg Arg Arg Gln  Ala Pro Ser Ile Ala  Thr Ile Gly 
    2105                 2110                 2115             


Ser Thr  Cys Asp Leu Asn Leu  Lys Ile Pro Gly Asn  Trp Phe Gln 
    2120                 2125                 2130             


Met Val  Ser Ala Gln Glu Arg  Leu Thr Arg Thr Phe  Thr Arg Ser 
    2135                 2140                 2145             


Ser His  Thr Tyr Thr Arg Thr  Glu Arg Thr Glu Ile  Ser Lys Thr 
    2150                 2155                 2160             


Arg Gly  Gly Glu Thr Lys Arg  Glu Val Arg Val Glu  Glu Ser Thr 
    2165                 2170                 2175             


Gln Val  Gly Gly Asp Pro Phe  Pro Ala Val Phe Gly  Asp Phe Leu 
    2180                 2185                 2190             


Gly Arg  Glu Arg Leu Gly Ser  Phe Gly Ser Ile Thr  Arg Gln Gln 
    2195                 2200                 2205             


Glu Gly  Glu Ala Ser Ser Gln  Asp Met Thr Ala Gln  Val Thr Ser 
    2210                 2215                 2220             


Pro Ser  Gly Lys Val Glu Ala  Ala Glu Ile Val Glu  Gly Glu Asp 
    2225                 2230                 2235             


Ser Ala  Tyr Ser Val Arg Phe  Val Pro Gln Glu Met  Gly Pro His 
    2240                 2245                 2250             


Thr Val  Ala Val Lys Tyr Arg  Gly Gln His Val Pro  Gly Ser Pro 
    2255                 2260                 2265             


Phe Gln  Phe Thr Val Gly Pro  Leu Gly Glu Gly Gly  Ala His Lys 
    2270                 2275                 2280             


Val Arg  Ala Gly Gly Thr Gly  Leu Glu Arg Gly Val  Ala Gly Val 
    2285                 2290                 2295             


Pro Ala  Glu Phe Ser Ile Trp  Thr Arg Glu Ala Gly  Ala Gly Gly 
    2300                 2305                 2310             


Leu Ser  Ile Ala Val Glu Gly  Pro Ser Lys Ala Glu  Ile Ala Phe 
    2315                 2320                 2325             


Glu Asp  Arg Lys Asp Gly Ser  Cys Gly Val Ser Tyr  Val Val Gln 
    2330                 2335                 2340             


Glu Pro  Gly Asp Tyr Glu Val  Ser Ile Lys Phe Asn  Asp Glu His 
    2345                 2350                 2355             


Ile Pro  Asp Ser Pro Phe Val  Val Pro Val Ala Ser  Leu Ser Asp 
    2360                 2365                 2370             


Asp Ala  Arg Arg Leu Thr Val  Thr Ser Leu Gln Glu  Thr Gly Leu 
    2375                 2380                 2385             


Lys Val  Asn Gln Pro Ala Ser  Phe Ala Val Gln Leu  Asn Gly Ala 
    2390                 2395                 2400             


Arg Gly  Val Ile Asp Ala Arg  Val His Thr Pro Ser  Gly Ala Val 
    2405                 2410                 2415             


Glu Glu  Cys Tyr Val Ser Glu  Leu Asp Ser Asp Lys  His Thr Ile 
    2420                 2425                 2430             


Arg Phe  Ile Pro His Glu Asn  Gly Val His Ser Ile  Asp Val Lys 
    2435                 2440                 2445             


Phe Asn  Gly Ala His Ile Pro  Gly Ser Pro Phe Lys  Ile Arg Val 
    2450                 2455                 2460             


Gly Glu  Gln Ser Gln Ala Gly  Asp Pro Gly Leu Val  Ser Ala Tyr 
    2465                 2470                 2475             


Gly Pro  Gly Leu Glu Gly Gly  Thr Thr Gly Val Ser  Ser Glu Phe 
    2480                 2485                 2490             


Ile Val  Asn Thr Leu Asn Ala  Gly Ser Gly Ala Leu  Ser Val Thr 
    2495                 2500                 2505             


Ile Asp  Gly Pro Ser Lys Val  Gln Leu Asp Cys Arg  Glu Cys Pro 
    2510                 2515                 2520             


Glu Gly  His Val Val Thr Tyr  Thr Pro Met Ala Pro  Gly Asn Tyr 
    2525                 2530                 2535             


Leu Ile  Ala Ile Lys Tyr Gly  Gly Pro Gln His Ile  Val Gly Ser 
    2540                 2545                 2550             


Pro Phe  Lys Ala Lys Val Thr  Gly Pro Arg Leu Ser  Gly Gly His 
    2555                 2560                 2565             


Ser Leu  His Glu Thr Ser Thr  Val Leu Val Glu Thr  Val Thr Lys 
    2570                 2575                 2580             


Ser Ser  Ser Ser Arg Gly Ser  Ser Tyr Ser Ser Ile  Pro Lys Phe 
    2585                 2590                 2595             


Ser Ser  Asp Ala Ser Lys Val  Val Thr Arg Gly Pro  Gly Leu Ser 
    2600                 2605                 2610             


Gln Ala  Phe Val Gly Gln Lys  Asn Ser Phe Thr Val  Asp Cys Ser 
    2615                 2620                 2625             


Lys Ala  Gly Thr Asn Met Met  Met Val Gly Val His  Gly Pro Lys 
    2630                 2635                 2640             


Thr Pro  Cys Glu Glu Val Tyr  Val Lys His Met Gly  Asn Arg Val 
    2645                 2650                 2655             


Tyr Asn  Val Thr Tyr Thr Val  Lys Glu Lys Gly Asp  Tyr Ile Leu 
    2660                 2665                 2670             


Ile Val  Lys Trp Gly Asp Glu  Ser Val Pro Gly Ser  Pro Phe Lys 
    2675                 2680                 2685             


Val Lys  Val Pro 
    2690         


<210>  4092
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLOT1__Homo_sapiens__NP_005794

<400>  4092

Met Phe Phe Thr Cys Gly Pro Asn Glu Ala Met Val Val Ser Gly Phe 
1               5                   10                  15      


Cys Arg Ser Pro Pro Val Met Val Ala Gly Gly Arg Val Phe Val Leu 
            20                  25                  30          


Pro Cys Ile Gln Gln Ile Gln Arg Ile Ser Leu Asn Thr Leu Thr Leu 
        35                  40                  45              


Asn Val Lys Ser Glu Lys Val Tyr Thr Arg His Gly Val Pro Ile Ser 
    50                  55                  60                  


Val Thr Gly Ile Ala Gln Val Lys Ile Gln Gly Gln Asn Lys Glu Met 
65                  70                  75                  80  


Leu Ala Ala Ala Cys Gln Met Phe Leu Gly Lys Thr Glu Ala Glu Ile 
                85                  90                  95      


Ala His Ile Ala Leu Glu Thr Leu Glu Gly His Gln Arg Ala Ile Met 
            100                 105                 110         


Ala His Met Thr Val Glu Glu Ile Tyr Lys Asp Arg Gln Lys Phe Ser 
        115                 120                 125             


Glu Gln Val Phe Lys Val Ala Ser Ser Asp Leu Val Asn Met Gly Ile 
    130                 135                 140                 


Ser Val Val Ser Tyr Thr Leu Lys Asp Ile His Asp Asp Gln Asp Tyr 
145                 150                 155                 160 


Leu His Ser Leu Gly Lys Ala Arg Thr Ala Gln Val Gln Lys Asp Ala 
                165                 170                 175     


Arg Ile Gly Glu Ala Glu Ala Lys Arg Asp Ala Gly Ile Arg Glu Ala 
            180                 185                 190         


Lys Ala Lys Gln Glu Lys Val Ser Ala Gln Tyr Leu Ser Glu Ile Glu 
        195                 200                 205             


Met Ala Lys Ala Gln Arg Asp Tyr Glu Leu Lys Lys Ala Ala Tyr Asp 
    210                 215                 220                 


Ile Glu Val Asn Thr Arg Arg Ala Gln Ala Asp Leu Ala Tyr Gln Leu 
225                 230                 235                 240 


Gln Val Ala Lys Thr Lys Gln Gln Ile Glu Glu Gln Arg Val Gln Val 
                245                 250                 255     


Gln Val Val Glu Arg Ala Gln Gln Val Ala Val Gln Glu Gln Glu Ile 
            260                 265                 270         


Ala Arg Arg Glu Lys Glu Leu Glu Ala Arg Val Arg Lys Pro Ala Glu 
        275                 280                 285             


Ala Glu Arg Tyr Lys Leu Glu Arg Leu Ala Glu Ala Glu Lys Ser Gln 
    290                 295                 300                 


Leu Ile Met Gln Ala Glu Ala Glu Ala Ala Ser Val Arg Met Arg Gly 
305                 310                 315                 320 


Glu Ala Glu Ala Phe Ala Ile Gly Ala Arg Ala Arg Ala Glu Ala Glu 
                325                 330                 335     


Gln Met Ala Lys Lys Ala Glu Ala Phe Gln Leu Tyr Gln Glu Ala Ala 
            340                 345                 350         


Gln Leu Asp Met Leu Leu Glu Lys Leu Pro Gln Val Ala Glu Glu Ile 
        355                 360                 365             


Ser Gly Pro Leu Thr Ser Ala Asn Lys Ile Thr Leu Val Ser Ser Gly 
    370                 375                 380                 


Ser Gly Thr Met Gly Ala Ala Lys Val Thr Gly Glu Val Leu Asp Ile 
385                 390                 395                 400 


Leu Thr Arg Leu Pro Glu Ser Val Glu Arg Leu Thr Gly Val Ser Ile 
                405                 410                 415     


Ser Gln Val Asn His Lys Pro Leu Arg Thr Ala 
            420                 425         


<210>  4093
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLOT2__Homo_sapiens__NP_004466

<400>  4093

Met Gly Asn Cys His Thr Val Gly Pro Asn Glu Ala Leu Val Val Ser 
1               5                   10                  15      


Gly Gly Cys Cys Gly Ser Asp Tyr Lys Gln Tyr Val Phe Gly Gly Trp 
            20                  25                  30          


Ala Trp Ala Trp Trp Cys Ile Ser Asp Thr Gln Arg Ile Ser Leu Glu 
        35                  40                  45              


Ile Met Thr Leu Gln Pro Arg Cys Glu Asp Val Glu Thr Ala Glu Gly 
    50                  55                  60                  


Val Ala Leu Thr Val Thr Gly Val Ala Gln Val Lys Ile Met Thr Glu 
65                  70                  75                  80  


Lys Glu Leu Leu Ala Val Ala Cys Glu Gln Phe Leu Gly Lys Asn Val 
                85                  90                  95      


Gln Asp Ile Lys Asn Val Val Leu Gln Thr Leu Glu Gly His Leu Arg 
            100                 105                 110         


Ser Ile Leu Gly Thr Leu Thr Val Glu Gln Ile Tyr Gln Asp Arg Asp 
        115                 120                 125             


Gln Phe Ala Lys Leu Val Arg Glu Val Ala Ala Pro Asp Val Gly Arg 
    130                 135                 140                 


Met Gly Ile Glu Ile Leu Ser Phe Thr Ile Lys Asp Val Tyr Asp Lys 
145                 150                 155                 160 


Val Asp Tyr Leu Ser Ser Leu Gly Lys Thr Gln Thr Ala Val Val Gln 
                165                 170                 175     


Arg Asp Ala Asp Ile Gly Val Ala Glu Ala Glu Arg Asp Ala Gly Ile 
            180                 185                 190         


Arg Glu Ala Glu Cys Lys Lys Glu Met Leu Asp Val Lys Phe Met Ala 
        195                 200                 205             


Asp Thr Lys Ile Ala Asp Ser Lys Arg Ala Phe Glu Leu Gln Lys Ser 
    210                 215                 220                 


Ala Phe Ser Glu Glu Val Asn Ile Lys Thr Ala Glu Ala Gln Leu Ala 
225                 230                 235                 240 


Tyr Glu Leu Gln Gly Ala Arg Glu Gln Gln Lys Ile Arg Gln Glu Glu 
                245                 250                 255     


Ile Glu Ile Glu Val Val Gln Arg Lys Lys Gln Ile Ala Val Glu Ala 
            260                 265                 270         


Gln Glu Ile Leu Arg Thr Asp Lys Glu Leu Ile Ala Thr Val Arg Arg 
        275                 280                 285             


Pro Ala Glu Ala Glu Ala His Arg Ile Gln Gln Ile Ala Glu Gly Glu 
    290                 295                 300                 


Lys Val Lys Gln Val Leu Leu Ala Gln Ala Glu Ala Glu Lys Ile Arg 
305                 310                 315                 320 


Lys Ile Gly Glu Ala Glu Ala Ala Val Ile Glu Ala Met Gly Lys Ala 
                325                 330                 335     


Glu Ala Glu Arg Met Lys Leu Lys Ala Glu Ala Tyr Gln Lys Tyr Gly 
            340                 345                 350         


Asp Ala Ala Lys Met Ala Leu Val Leu Glu Ala Leu Pro Gln Ile Ala 
        355                 360                 365             


Ala Lys Ile Ala Ala Pro Leu Thr Lys Val Asp Glu Ile Val Val Leu 
    370                 375                 380                 


Ser Gly Asp Asn Ser Lys Val Thr Ser Glu Val Asn Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Leu Pro Ala Ser Val His Ala Leu Thr Gly Val Asp Leu Ser Lys 
                405                 410                 415     


Ile Pro Leu Ile Lys Lys Ala Thr Gly Val Gln Val 
            420                 425             


<210>  4094
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLRT2__Homo_sapiens__NP_037363

<400>  4094

Met Gly Leu Gln Thr Thr Lys Trp Pro Ser His Gly Ala Phe Phe Leu 
1               5                   10                  15      


Lys Ser Trp Leu Ile Ile Ser Leu Gly Leu Tyr Ser Gln Val Ser Lys 
            20                  25                  30          


Leu Leu Ala Cys Pro Ser Val Cys Arg Cys Asp Arg Asn Phe Val Tyr 
        35                  40                  45              


Cys Asn Glu Arg Ser Leu Thr Ser Val Pro Leu Gly Ile Pro Glu Gly 
    50                  55                  60                  


Val Thr Val Leu Tyr Leu His Asn Asn Gln Ile Asn Asn Ala Gly Phe 
65                  70                  75                  80  


Pro Ala Glu Leu His Asn Val Gln Ser Val His Thr Val Tyr Leu Tyr 
                85                  90                  95      


Gly Asn Gln Leu Asp Glu Phe Pro Met Asn Leu Pro Lys Asn Val Arg 
            100                 105                 110         


Val Leu His Leu Gln Glu Asn Asn Ile Gln Thr Ile Ser Arg Ala Ala 
        115                 120                 125             


Leu Ala Gln Leu Leu Lys Leu Glu Glu Leu His Leu Asp Asp Asn Ser 
    130                 135                 140                 


Ile Ser Thr Val Gly Val Glu Asp Gly Ala Phe Arg Glu Ala Ile Ser 
145                 150                 155                 160 


Leu Lys Leu Leu Phe Leu Ser Lys Asn His Leu Ser Ser Val Pro Val 
                165                 170                 175     


Gly Leu Pro Val Asp Leu Gln Glu Leu Arg Val Asp Glu Asn Arg Ile 
            180                 185                 190         


Ala Val Ile Ser Asp Met Ala Phe Gln Asn Leu Thr Ser Leu Glu Arg 
        195                 200                 205             


Leu Ile Val Asp Gly Asn Leu Leu Thr Asn Lys Gly Ile Ala Glu Gly 
    210                 215                 220                 


Thr Phe Ser His Leu Thr Lys Leu Lys Glu Phe Ser Ile Val Arg Asn 
225                 230                 235                 240 


Ser Leu Ser His Pro Pro Pro Asp Leu Pro Gly Thr His Leu Ile Arg 
                245                 250                 255     


Leu Tyr Leu Gln Asp Asn Gln Ile Asn His Ile Pro Leu Thr Ala Phe 
            260                 265                 270         


Ser Asn Leu Arg Lys Leu Glu Arg Leu Asp Ile Ser Asn Asn Gln Leu 
        275                 280                 285             


Arg Met Leu Thr Gln Gly Val Phe Asp Asn Leu Ser Asn Leu Lys Gln 
    290                 295                 300                 


Leu Thr Ala Arg Asn Asn Pro Trp Phe Cys Asp Cys Ser Ile Lys Trp 
305                 310                 315                 320 


Val Thr Glu Trp Leu Lys Tyr Ile Pro Ser Ser Leu Asn Val Arg Gly 
                325                 330                 335     


Phe Met Cys Gln Gly Pro Glu Gln Val Arg Gly Met Ala Val Arg Glu 
            340                 345                 350         


Leu Asn Met Asn Leu Leu Ser Cys Pro Thr Thr Thr Pro Gly Leu Pro 
        355                 360                 365             


Leu Phe Thr Pro Ala Pro Ser Thr Ala Ser Pro Thr Thr Gln Pro Pro 
    370                 375                 380                 


Thr Leu Ser Ile Pro Asn Pro Ser Arg Ser Tyr Thr Pro Pro Thr Pro 
385                 390                 395                 400 


Thr Thr Ser Lys Leu Pro Thr Ile Pro Asp Trp Asp Gly Arg Glu Arg 
                405                 410                 415     


Val Thr Pro Pro Ile Ser Glu Arg Ile Gln Leu Ser Ile His Phe Val 
            420                 425                 430         


Asn Asp Thr Ser Ile Gln Val Ser Trp Leu Ser Leu Phe Thr Val Met 
        435                 440                 445             


Ala Tyr Lys Leu Thr Trp Val Lys Met Gly His Ser Leu Val Gly Gly 
    450                 455                 460                 


Ile Val Gln Glu Arg Ile Val Ser Gly Glu Lys Gln His Leu Ser Leu 
465                 470                 475                 480 


Val Asn Leu Glu Pro Arg Ser Thr Tyr Arg Ile Cys Leu Val Pro Leu 
                485                 490                 495     


Asp Ala Phe Asn Tyr Arg Ala Val Glu Asp Thr Ile Cys Ser Glu Ala 
            500                 505                 510         


Thr Thr His Ala Ser Tyr Leu Asn Asn Gly Ser Asn Thr Ala Ser Ser 
        515                 520                 525             


His Glu Gln Thr Thr Ser His Ser Met Gly Ser Pro Phe Leu Leu Ala 
    530                 535                 540                 


Gly Leu Ile Gly Gly Ala Val Ile Phe Val Leu Val Val Leu Leu Ser 
545                 550                 555                 560 


Val Phe Cys Trp His Met His Lys Lys Gly Arg Tyr Thr Ser Gln Lys 
                565                 570                 575     


Trp Lys Tyr Asn Arg Gly Arg Arg Lys Asp Asp Tyr Cys Glu Ala Gly 
            580                 585                 590         


Thr Lys Lys Asp Asn Ser Ile Leu Glu Met Thr Glu Thr Ser Phe Gln 
        595                 600                 605             


Ile Val Ser Leu Asn Asn Asp Gln Leu Leu Lys Gly Asp Phe Arg Leu 
    610                 615                 620                 


Gln Pro Ile Tyr Thr Pro Asn Gly Gly Ile Asn Tyr Thr Asp Cys His 
625                 630                 635                 640 


Ile Pro Asn Asn Met Arg Tyr Cys Asn Ser Ser Val Pro Asp Leu Glu 
                645                 650                 655     


His Cys His Thr 
            660 


<210>  4095
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLRT3__Homo_sapiens__NP_938205

<400>  4095

Met Ile Ser Ala Ala Trp Ser Ile Phe Leu Ile Gly Thr Lys Ile Gly 
1               5                   10                  15      


Leu Phe Leu Gln Val Ala Pro Leu Ser Val Met Ala Lys Ser Cys Pro 
            20                  25                  30          


Ser Val Cys Arg Cys Asp Ala Gly Phe Ile Tyr Cys Asn Asp Arg Phe 
        35                  40                  45              


Leu Thr Ser Ile Pro Thr Gly Ile Pro Glu Asp Ala Thr Thr Leu Tyr 
    50                  55                  60                  


Leu Gln Asn Asn Gln Ile Asn Asn Ala Gly Ile Pro Ser Asp Leu Lys 
65                  70                  75                  80  


Asn Leu Leu Lys Val Glu Arg Ile Tyr Leu Tyr His Asn Ser Leu Asp 
                85                  90                  95      


Glu Phe Pro Thr Asn Leu Pro Lys Tyr Val Lys Glu Leu His Leu Gln 
            100                 105                 110         


Glu Asn Asn Ile Arg Thr Ile Thr Tyr Asp Ser Leu Ser Lys Ile Pro 
        115                 120                 125             


Tyr Leu Glu Glu Leu His Leu Asp Asp Asn Ser Val Ser Ala Val Ser 
    130                 135                 140                 


Ile Glu Glu Gly Ala Phe Arg Asp Ser Asn Tyr Leu Arg Leu Leu Phe 
145                 150                 155                 160 


Leu Ser Arg Asn His Leu Ser Thr Ile Pro Trp Gly Leu Pro Arg Thr 
                165                 170                 175     


Ile Glu Glu Leu Arg Leu Asp Asp Asn Arg Ile Ser Thr Ile Ser Ser 
            180                 185                 190         


Pro Ser Leu Gln Gly Leu Thr Ser Leu Lys Arg Leu Val Leu Asp Gly 
        195                 200                 205             


Asn Leu Leu Asn Asn His Gly Leu Gly Asp Lys Val Phe Phe Asn Leu 
    210                 215                 220                 


Val Asn Leu Thr Glu Leu Ser Leu Val Arg Asn Ser Leu Thr Ala Ala 
225                 230                 235                 240 


Pro Val Asn Leu Pro Gly Thr Asn Leu Arg Lys Leu Tyr Leu Gln Asp 
                245                 250                 255     


Asn His Ile Asn Arg Val Pro Pro Asn Ala Phe Ser Tyr Leu Arg Gln 
            260                 265                 270         


Leu Tyr Arg Leu Asp Met Ser Asn Asn Asn Leu Ser Asn Leu Pro Gln 
        275                 280                 285             


Gly Ile Phe Asp Asp Leu Asp Asn Ile Thr Gln Leu Ile Leu Arg Asn 
    290                 295                 300                 


Asn Pro Trp Tyr Cys Gly Cys Lys Met Lys Trp Val Arg Asp Trp Leu 
305                 310                 315                 320 


Gln Ser Leu Pro Val Lys Val Asn Val Arg Gly Leu Met Cys Gln Ala 
                325                 330                 335     


Pro Glu Lys Val Arg Gly Met Ala Ile Lys Asp Leu Asn Ala Glu Leu 
            340                 345                 350         


Phe Asp Cys Lys Asp Ser Gly Ile Val Ser Thr Ile Gln Ile Thr Thr 
        355                 360                 365             


Ala Ile Pro Asn Thr Val Tyr Pro Ala Gln Gly Gln Trp Pro Ala Pro 
    370                 375                 380                 


Val Thr Lys Gln Pro Asp Ile Lys Asn Pro Lys Leu Thr Lys Asp His 
385                 390                 395                 400 


Gln Thr Thr Gly Ser Pro Ser Arg Lys Thr Ile Thr Ile Thr Val Lys 
                405                 410                 415     


Ser Val Thr Ser Asp Thr Ile His Ile Ser Trp Lys Leu Ala Leu Pro 
            420                 425                 430         


Met Thr Ala Leu Arg Leu Ser Trp Leu Lys Leu Gly His Ser Pro Ala 
        435                 440                 445             


Phe Gly Ser Ile Thr Glu Thr Ile Val Thr Gly Glu Arg Ser Glu Tyr 
    450                 455                 460                 


Leu Val Thr Ala Leu Glu Pro Asp Ser Pro Tyr Lys Val Cys Met Val 
465                 470                 475                 480 


Pro Met Glu Thr Ser Asn Leu Tyr Leu Phe Asp Glu Thr Pro Val Cys 
                485                 490                 495     


Ile Glu Thr Glu Thr Ala Pro Leu Arg Met Tyr Asn Pro Thr Thr Thr 
            500                 505                 510         


Leu Asn Arg Glu Gln Glu Lys Glu Pro Tyr Lys Asn Pro Asn Leu Pro 
        515                 520                 525             


Leu Ala Ala Ile Ile Gly Gly Ala Val Ala Leu Val Thr Ile Ala Leu 
    530                 535                 540                 


Leu Ala Leu Val Cys Trp Tyr Val His Arg Asn Gly Ser Leu Phe Ser 
545                 550                 555                 560 


Arg Asn Cys Ala Tyr Ser Lys Gly Arg Arg Arg Lys Asp Asp Tyr Ala 
                565                 570                 575     


Glu Ala Gly Thr Lys Lys Asp Asn Ser Ile Leu Glu Ile Arg Glu Thr 
            580                 585                 590         


Ser Phe Gln Met Leu Pro Ile Ser Asn Glu Pro Ile Ser Lys Glu Glu 
        595                 600                 605             


Phe Val Ile His Thr Ile Phe Pro Pro Asn Gly Met Asn Leu Tyr Lys 
    610                 615                 620                 


Asn Asn His Ser Glu Ser Ser Ser Asn Arg Ser Tyr Arg Asp Ser Gly 
625                 630                 635                 640 


Ile Pro Asp Ser Asp His Ser His Ser 
                645                 


<210>  4096
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT1__Homo_sapiens__NP_001153392

<400>  4096

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Gly Glu His Cys Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe 
            660                 665                 670         


Lys Ser Thr Arg Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His 
        675                 680                 685         


<210>  4097
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3__Homo_sapiens__NP_004110

<400>  4097

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  4098
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3LG__Homo_sapiens__NP_001450

<400>  4098

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  4099
<211>  1298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT4__Homo_sapiens__NP_002011

<400>  4099

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Arg 
    1295             


<210>  4100
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLVCR1__Homo_sapiens__NP_054772

<400>  4100

Met Ala Arg Pro Asp Asp Glu Glu Gly Ala Ala Val Ala Pro Gly His 
1               5                   10                  15      


Pro Leu Ala Lys Gly Tyr Leu Pro Leu Pro Arg Gly Ala Pro Val Gly 
            20                  25                  30          


Lys Glu Ser Val Glu Leu Gln Asn Gly Pro Lys Ala Gly Thr Phe Pro 
        35                  40                  45              


Val Asn Gly Ala Pro Arg Asp Ser Leu Ala Ala Ala Ser Gly Val Leu 
    50                  55                  60                  


Gly Gly Pro Gln Thr Pro Leu Ala Pro Glu Glu Glu Thr Gln Ala Arg 
65                  70                  75                  80  


Leu Leu Pro Ala Gly Ala Gly Ala Glu Thr Pro Gly Ala Glu Ser Ser 
                85                  90                  95      


Pro Leu Pro Leu Thr Ala Leu Ser Pro Arg Arg Phe Val Val Leu Leu 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Leu Val Asn Ala Phe Gln Trp Ile Gln Tyr 
        115                 120                 125             


Ser Ile Ile Ser Asn Val Phe Glu Gly Phe Tyr Gly Val Thr Leu Leu 
    130                 135                 140                 


His Ile Asp Trp Leu Ser Met Val Tyr Met Leu Ala Tyr Val Pro Leu 
145                 150                 155                 160 


Ile Phe Pro Ala Thr Trp Leu Leu Asp Thr Arg Gly Leu Arg Leu Thr 
                165                 170                 175     


Ala Leu Leu Gly Ser Gly Leu Asn Cys Leu Gly Ala Trp Ile Lys Cys 
            180                 185                 190         


Gly Ser Val Gln Gln His Leu Phe Trp Val Thr Met Leu Gly Gln Cys 
        195                 200                 205             


Leu Cys Ser Val Ala Gln Val Phe Ile Leu Gly Leu Pro Ser Arg Ile 
    210                 215                 220                 


Ala Ser Val Trp Phe Gly Pro Lys Glu Val Ser Thr Ala Cys Ala Thr 
225                 230                 235                 240 


Ala Val Leu Gly Asn Gln Leu Gly Thr Ala Val Gly Phe Leu Leu Pro 
                245                 250                 255     


Pro Val Leu Val Pro Asn Thr Gln Asn Asp Thr Asn Leu Leu Ala Cys 
            260                 265                 270         


Asn Ile Ser Thr Met Phe Tyr Gly Thr Ser Ala Val Ala Thr Leu Leu 
        275                 280                 285             


Phe Ile Leu Thr Ala Ile Ala Phe Lys Glu Lys Pro Arg Tyr Pro Pro 
    290                 295                 300                 


Ser Gln Ala Gln Ala Ala Leu Gln Asp Ser Pro Pro Glu Glu Tyr Ser 
305                 310                 315                 320 


Tyr Lys Lys Ser Ile Arg Asn Leu Phe Lys Asn Ile Pro Phe Val Leu 
                325                 330                 335     


Leu Leu Ile Thr Tyr Gly Ile Met Thr Gly Ala Phe Tyr Ser Val Ser 
            340                 345                 350         


Thr Leu Leu Asn Gln Met Ile Leu Thr Tyr Tyr Glu Gly Glu Glu Val 
        355                 360                 365             


Asn Ala Gly Arg Ile Gly Leu Thr Leu Val Val Ala Gly Met Val Gly 
    370                 375                 380                 


Ser Ile Leu Cys Gly Leu Trp Leu Asp Tyr Thr Lys Thr Tyr Lys Gln 
385                 390                 395                 400 


Thr Thr Leu Ile Val Tyr Ile Leu Ser Phe Ile Gly Met Val Ile Phe 
                405                 410                 415     


Thr Phe Thr Leu Asp Leu Arg Tyr Ile Ile Ile Val Phe Val Thr Gly 
            420                 425                 430         


Gly Val Leu Gly Phe Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu 
        435                 440                 445             


Phe Ala Val Glu Ile Thr Tyr Pro Glu Ser Glu Gly Thr Ser Ser Gly 
    450                 455                 460                 


Leu Leu Asn Ala Ser Ala Gln Ile Phe Gly Ile Leu Phe Thr Leu Ala 
465                 470                 475                 480 


Gln Gly Lys Leu Thr Ser Asp Tyr Gly Pro Lys Ala Gly Asn Ile Phe 
                485                 490                 495     


Leu Cys Val Trp Met Phe Ile Gly Ile Ile Leu Thr Ala Leu Ile Lys 
            500                 505                 510         


Ser Asp Leu Arg Arg His Asn Ile Asn Ile Gly Ile Thr Asn Val Asp 
        515                 520                 525             


Val Lys Ala Ile Pro Ala Asp Ser Pro Thr Asp Gln Glu Pro Lys Thr 
    530                 535                 540                 


Val Met Leu Ser Lys Gln Ser Glu Ser Ala Ile 
545                 550                 555 


<210>  4101
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLVCR2__Homo_sapiens__NP_001182212

<400>  4101

Met Ser Ala Asp Asn Ser Ser Thr Ile Cys Val Cys Arg Ser Val Arg 
1               5                   10                  15      


Gln Glu Leu Gly Ile Ala Ile Gly Phe Leu Val Pro Pro Val Leu Val 
            20                  25                  30          


Pro Asn Ile Glu Asp Arg Asp Glu Leu Ala Tyr His Ile Ser Ile Met 
        35                  40                  45              


Phe Tyr Ile Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val Ile 
    50                  55                  60                  


Ile Val Phe Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln Ser 
65                  70                  75                  80  


Leu Ser Tyr Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser Ile 
                85                  90                  95      


Ala Arg Leu Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr Tyr 
            100                 105                 110         


Gly Leu Asn Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn Arg 
        115                 120                 125             


Met Val Ile Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg Ile 
    130                 135                 140                 


Gly Leu Thr Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser Gly 
145                 150                 155                 160 


Ile Trp Leu Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val Val 
                165                 170                 175     


Tyr Ile Met Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu Asn 
            180                 185                 190         


Leu Gly His Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly Phe 
        195                 200                 205             


Phe Met Thr Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu Leu 
    210                 215                 220                 


Thr Tyr Pro Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile Ser 
225                 230                 235                 240 


Ala Gln Val Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile Ile 
                245                 250                 255     


Asp Asn Tyr Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe Leu 
            260                 265                 270         


Thr Leu Gly Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg Arg 
        275                 280                 285             


Gln Lys Ala Asn Lys Glu Thr Leu Glu Asn Lys Leu Gln Glu Glu Glu 
    290                 295                 300                 


Glu Glu Ser Asn Thr Ser Lys Val Pro Thr Ala Val Ser Glu Asp His 
305                 310                 315                 320 


Leu 
    


<210>  4102
<211>  1196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMN1__Homo_sapiens__NP_001096654

<400>  4102

Met Glu Asn Val Asp Asn Ser Leu Asp Gly Ser Asp Val Ser Glu Pro 
1               5                   10                  15      


Ala Lys Pro Glu Ala Gly Leu Glu Val Ala Gln Ser Ile Leu Ser Lys 
            20                  25                  30          


Phe Ser Met Lys Ser Leu Phe Gly Phe Thr Ser Lys Leu Glu Ser Val 
        35                  40                  45              


Asn Pro Glu Glu Glu Asp Ala Val Leu Lys Ala Phe His Ser Leu Asp 
    50                  55                  60                  


Val Asn Pro Thr Ser Gln Gln Asp Asp Ser Ser Asn Gly Leu Asp Pro 
65                  70                  75                  80  


Gln Glu Ala Gly Ser Arg Val Ser Pro Asp Leu Gly Asn Asp Glu Lys 
                85                  90                  95      


Ile Ala Ser Val Glu Thr Glu Ser Glu Gly Ser Gln Arg Lys Glu Ala 
            100                 105                 110         


Gly Thr Ser Leu Leu Ala Gln Glu Leu Leu Pro Leu Ser Thr Leu Lys 
        115                 120                 125             


Gly Thr Lys Asp Asp Val Ile Cys Val Arg Gly Thr Leu Val His Thr 
    130                 135                 140                 


Thr Ser Asp Ser Asp Ser Asp Asp Gly Gly Gln Glu Pro Glu Glu Gly 
145                 150                 155                 160 


Ser Ser Thr Asn Gly Pro Lys Ser Pro Ser Gly Val Leu Ser Glu Pro 
                165                 170                 175     


Ser Gln Glu Ser Lys Glu Asn Pro Gly Gly Phe Arg Glu Asn Thr Val 
            180                 185                 190         


Thr Gly Glu Met Asn Gly Ala Glu Leu Cys Ala Glu Asp Pro Gln Arg 
        195                 200                 205             


Ile Pro Pro Glu Met Ser Ser Lys Leu Glu Ala Gly Asn Gly Gly Leu 
    210                 215                 220                 


Gln Thr Glu Arg Arg Pro Ser Gln Asp Gln Val Gly Glu Glu Gly Ser 
225                 230                 235                 240 


Gln Asp Leu Pro Ala Val Thr Asn Gln Asn Ser Ser Val Gly Ile Thr 
                245                 250                 255     


Glu Ser Ala Ser Ser Lys Lys Glu Val Ser Gly Glu Lys Ser Phe Gln 
            260                 265                 270         


Leu Pro Ala Phe Phe Ser Gly Leu Arg Val Leu Lys Lys Gly Ala Thr 
        275                 280                 285             


Ala Glu Gly Gly Glu Thr Ile Thr Glu Ile Lys Pro Lys Asp Gly Asp 
    290                 295                 300                 


Leu Ala Leu Leu Lys Leu Thr Gln Pro Val Gln Lys Ser Leu Val Gln 
305                 310                 315                 320 


Ala Gly Leu Gln Thr Val Lys Ser Glu Lys Lys Ala Thr Asp Pro Lys 
                325                 330                 335     


Ala Thr Pro Thr Leu Leu Glu Gln Leu Ser Leu Leu Leu Asn Ile Asp 
            340                 345                 350         


Met Pro Lys Thr Glu Pro Lys Gly Ala Asp Pro Glu Ser Pro Arg Arg 
        355                 360                 365             


Glu Glu Met Gly Cys Asn Ala Asp Gln Glu Ser Gln Ser Gly Pro Gly 
    370                 375                 380                 


Val Pro Gln Thr Gln Gly Gly Glu Val Lys Pro Lys Ser Pro Glu Thr 
385                 390                 395                 400 


Ala Leu Glu Ala Phe Lys Ala Leu Phe Ile Arg Pro Pro Arg Lys Gly 
                405                 410                 415     


Thr Thr Ala Asp Thr Ser Glu Leu Glu Ala Leu Lys Arg Lys Met Arg 
            420                 425                 430         


His Glu Lys Glu Ser Leu Arg Ala Val Phe Glu Arg Ser Asn Ser Lys 
        435                 440                 445             


Pro Ala Asp Gly Pro Ser Asp Ser Lys Ser Pro Asp His Ser Leu Thr 
    450                 455                 460                 


Glu Gln Asp Asp Arg Thr Pro Gly Arg Leu Gln Ala Val Trp Pro Pro 
465                 470                 475                 480 


Pro Lys Thr Lys Asp Thr Glu Glu Lys Val Gly Leu Lys Tyr Thr Glu 
                485                 490                 495     


Ala Glu Tyr Gln Ala Ala Ile Leu His Leu Lys Arg Glu His Lys Glu 
            500                 505                 510         


Glu Ile Glu Asn Leu Gln Ala Gln Phe Glu Leu Arg Ala Phe His Ile 
        515                 520                 525             


Arg Gly Glu His Ala Met Ile Thr Ala Arg Leu Glu Glu Thr Ile Glu 
    530                 535                 540                 


Asn Leu Lys His Glu Leu Glu His Arg Trp Arg Gly Gly Cys Glu Glu 
545                 550                 555                 560 


Arg Lys Asp Val Cys Ile Ser Thr Asp Asp Asp Cys Pro Pro Lys Thr 
                565                 570                 575     


Phe Arg Asn Val Cys Val Gln Thr Asp Arg Glu Thr Phe Leu Lys Pro 
            580                 585                 590         


Cys Glu Ser Glu Ser Lys Thr Thr Arg Ser Asn Gln Leu Val Pro Lys 
        595                 600                 605             


Lys Leu Asn Ile Ser Ser Leu Ser Gln Leu Ser Pro Pro Asn Asp His 
    610                 615                 620                 


Lys Asp Ile His Ala Ala Leu Gln Pro Met Glu Gly Met Ala Ser Asn 
625                 630                 635                 640 


Gln Gln Lys Ala Leu Pro Pro Pro Pro Ala Ser Ile Pro Pro Pro Pro 
                645                 650                 655     


Pro Leu Pro Ser Gly Leu Gly Ser Leu Ser Pro Ala Pro Pro Met Pro 
            660                 665                 670         


Pro Val Ser Ala Gly Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro 
        675                 680                 685             


Pro Leu Pro Pro Pro Ser Ser Ala Gly Pro Pro Pro Pro Pro Pro Pro 
    690                 695                 700                 


Pro Pro Leu Pro Asn Ser Pro Ala Pro Pro Asn Pro Gly Gly Pro Pro 
705                 710                 715                 720 


Pro Ala Pro Pro Pro Pro Gly Leu Ala Pro Pro Pro Pro Pro Gly Leu 
                725                 730                 735     


Phe Phe Gly Leu Gly Ser Ser Ser Ser Gln Cys Pro Arg Lys Pro Ala 
            740                 745                 750         


Ile Glu Pro Ser Cys Pro Met Lys Pro Leu Tyr Trp Thr Arg Ile Gln 
        755                 760                 765             


Ile Ser Asp Arg Ser Gln Asn Ala Thr Pro Thr Leu Trp Asp Ser Leu 
    770                 775                 780                 


Glu Glu Pro Asp Ile Arg Asp Pro Ser Glu Phe Glu Tyr Leu Phe Ser 
785                 790                 795                 800 


Lys Asp Thr Thr Gln Gln Lys Lys Lys Pro Leu Ser Glu Thr Tyr Glu 
                805                 810                 815     


Lys Lys Asn Lys Val Lys Lys Ile Ile Lys Leu Leu Asp Gly Lys Arg 
            820                 825                 830         


Ser Gln Thr Val Gly Ile Leu Ile Ser Ser Leu His Leu Glu Met Lys 
        835                 840                 845             


Asp Ile Gln Gln Ala Ile Phe Asn Val Asp Asp Ser Val Val Asp Leu 
    850                 855                 860                 


Glu Thr Leu Ala Ala Leu Tyr Glu Asn Arg Ala Gln Glu Asp Glu Leu 
865                 870                 875                 880 


Val Lys Ile Arg Lys Tyr Tyr Glu Thr Ser Lys Glu Glu Glu Leu Lys 
                885                 890                 895     


Leu Leu Asp Lys Pro Glu Gln Phe Leu His Glu Leu Ala Gln Ile Pro 
            900                 905                 910         


Asn Phe Ala Glu Arg Ala Gln Cys Ile Ile Phe Arg Ser Val Phe Ser 
        915                 920                 925             


Glu Gly Ile Thr Ser Leu His Arg Lys Val Glu Ile Ile Thr Arg Ala 
    930                 935                 940                 


Ser Lys Asp Leu Leu His Val Lys Ser Val Lys Asp Ile Leu Ala Leu 
945                 950                 955                 960 


Ile Leu Ala Phe Gly Asn Tyr Met Asn Gly Gly Asn Arg Thr Arg Gly 
                965                 970                 975     


Gln Ala Asp Gly Tyr Ser Leu Glu Ile Leu Pro Lys Leu Lys Asp Val 
            980                 985                 990         


Lys Ser Arg Asp Asn Gly Ile Asn  Leu Val Asp Tyr Val  Val Lys Tyr 
        995                 1000                 1005             


Tyr Leu  Arg Tyr Tyr Asp Gln  Glu Ala Gly Thr Glu  Lys Ser Val 
    1010                 1015                 1020             


Phe Pro  Leu Pro Glu Pro Gln  Asp Phe Phe Leu Ala  Ser Gln Val 
    1025                 1030                 1035             


Lys Phe  Glu Asp Leu Ile Lys  Asp Leu Arg Lys Leu  Lys Arg Gln 
    1040                 1045                 1050             


Leu Glu  Ala Ser Glu Lys Gln  Met Val Val Val Cys  Lys Glu Ser 
    1055                 1060                 1065             


Pro Lys  Glu Tyr Leu Gln Pro  Phe Lys Asp Lys Leu  Glu Glu Phe 
    1070                 1075                 1080             


Phe Gln  Lys Ala Lys Lys Glu  His Lys Met Glu Glu  Ser His Leu 
    1085                 1090                 1095             


Glu Asn  Ala Gln Lys Ser Phe  Glu Thr Thr Val Arg  Tyr Phe Gly 
    1100                 1105                 1110             


Met Lys  Pro Lys Ser Gly Glu  Lys Glu Ile Thr Pro  Ser Tyr Val 
    1115                 1120                 1125             


Phe Met  Val Trp Tyr Glu Phe  Cys Ser Asp Phe Lys  Thr Ile Trp 
    1130                 1135                 1140             


Lys Arg  Glu Ser Lys Asn Ile  Ser Lys Glu Arg Leu  Lys Met Ala 
    1145                 1150                 1155             


Gln Glu  Ser Val Ser Lys Leu  Thr Ser Glu Lys Lys  Val Glu Thr 
    1160                 1165                 1170             


Lys Lys  Ile Asn Pro Thr Ala  Ser Leu Lys Glu Arg  Leu Arg Gln 
    1175                 1180                 1185             


Lys Glu  Ala Ser Val Thr Thr  Asn 
    1190                 1195     


<210>  4103
<211>  1722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMN2__Homo_sapiens__NP_064450

<400>  4103

Met Gly Asn Gln Asp Gly Lys Leu Lys Arg Ser Ala Gly Asp Ala Leu 
1               5                   10                  15      


His Glu Gly Gly Gly Gly Ala Glu Asp Ala Leu Gly Pro Arg Asp Val 
            20                  25                  30          


Glu Ala Thr Lys Lys Gly Ser Gly Gly Lys Lys Ala Leu Gly Lys His 
        35                  40                  45              


Gly Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ser Gly Lys Lys 
    50                  55                  60                  


Lys Ser Lys Ser Asp Ser Arg Ala Ser Val Phe Ser Asn Leu Arg Ile 
65                  70                  75                  80  


Arg Lys Asn Leu Ser Lys Gly Lys Gly Ala Gly Gly Ser Arg Glu Asp 
                85                  90                  95      


Val Leu Asp Ser Gln Ala Leu Gln Thr Gly Glu Leu Asp Ser Ala His 
            100                 105                 110         


Ser Leu Leu Thr Lys Thr Pro Asp Leu Ser Leu Ser Ala Asp Glu Ala 
        115                 120                 125             


Gly Leu Ser Asp Thr Glu Cys Ala Asp Pro Phe Glu Val Thr Gly Pro 
    130                 135                 140                 


Gly Gly Pro Gly Pro Ala Glu Ala Arg Val Gly Gly Arg Pro Ile Ala 
145                 150                 155                 160 


Glu Asp Val Glu Thr Ala Ala Gly Ala Gln Asp Gly Gln Arg Thr Ser 
                165                 170                 175     


Ser Gly Ser Asp Thr Asp Ile Tyr Ser Phe His Ser Ala Thr Glu Gln 
            180                 185                 190         


Glu Asp Leu Leu Ser Asp Ile Gln Gln Ala Ile Arg Leu Gln Gln Gln 
        195                 200                 205             


Gln Gln Gln Gln Leu Gln Leu Gln Leu Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gly Ala Glu Glu Pro Ala Ala Pro Pro Thr Ala Val Ser 
225                 230                 235                 240 


Pro Gln Pro Gly Ala Phe Leu Gly Leu Asp Arg Phe Leu Leu Gly Pro 
                245                 250                 255     


Ser Gly Gly Ala Gly Glu Ala Pro Gly Ser Pro Asp Thr Glu Gln Ala 
            260                 265                 270         


Leu Ser Ala Leu Ser Asp Leu Pro Glu Ser Leu Ala Ala Glu Pro Arg 
        275                 280                 285             


Glu Pro Gln Gln Pro Pro Ser Pro Gly Gly Leu Pro Val Ser Glu Ala 
    290                 295                 300                 


Pro Ser Leu Pro Ala Ala Gln Pro Ala Ala Lys Asp Ser Pro Ser Ser 
305                 310                 315                 320 


Thr Ala Phe Pro Phe Pro Glu Ala Gly Pro Gly Glu Glu Ala Ala Gly 
                325                 330                 335     


Ala Pro Val Arg Gly Ala Gly Asp Thr Asp Glu Glu Gly Glu Glu Asp 
            340                 345                 350         


Ala Phe Glu Asp Ala Pro Arg Gly Ser Pro Gly Glu Glu Trp Ala Pro 
        355                 360                 365             


Glu Val Gly Glu Asp Ala Pro Gln Arg Leu Gly Glu Glu Pro Glu Glu 
    370                 375                 380                 


Glu Ala Gln Gly Pro Asp Ala Pro Ala Ala Ala Ser Leu Pro Gly Ser 
385                 390                 395                 400 


Pro Ala Pro Ser Gln Arg Cys Phe Lys Pro Tyr Pro Leu Ile Thr Pro 
                405                 410                 415     


Cys Tyr Ile Lys Thr Thr Thr Arg Gln Leu Ser Ser Pro Asn His Ser 
            420                 425                 430         


Pro Ser Gln Ser Pro Asn Gln Ser Pro Arg Ile Lys Arg Arg Pro Glu 
        435                 440                 445             


Pro Ser Leu Ser Arg Gly Ser Arg Thr Ala Leu Ala Ser Val Ala Ala 
    450                 455                 460                 


Pro Ala Lys Lys His Arg Ala Asp Gly Gly Leu Ala Ala Gly Leu Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Trp Thr Glu Glu Leu Gly Ala Arg Thr Pro Arg Val 
                485                 490                 495     


Gly Gly Ser Ala His Leu Leu Glu Arg Gly Val Ala Ser Asp Ser Gly 
            500                 505                 510         


Gly Gly Val Ser Pro Ala Leu Ala Ala Lys Ala Ser Gly Ala Pro Ala 
        515                 520                 525             


Ala Ala Asp Gly Phe Gln Asn Val Phe Thr Gly Arg Thr Leu Leu Glu 
    530                 535                 540                 


Lys Leu Phe Ser Gln Gln Glu Asn Gly Pro Pro Glu Glu Ala Glu Lys 
545                 550                 555                 560 


Phe Cys Ser Arg Ile Ile Ala Met Gly Leu Leu Leu Pro Phe Ser Asp 
                565                 570                 575     


Cys Phe Arg Glu Pro Cys Asn Gln Asn Ala Gln Thr Asn Ala Ala Ser 
            580                 585                 590         


Phe Asp Gln Asp Gln Leu Tyr Thr Trp Ala Ala Val Ser Gln Pro Thr 
        595                 600                 605             


His Ser Leu Asp Tyr Ser Glu Gly Gln Phe Pro Arg Arg Val Pro Ser 
    610                 615                 620                 


Met Gly Pro Pro Ser Lys Pro Pro Asp Glu Glu His Arg Leu Glu Asp 
625                 630                 635                 640 


Ala Glu Thr Glu Ser Gln Ser Ala Val Ser Glu Thr Pro Gln Lys Arg 
                645                 650                 655     


Ser Asp Ala Val Gln Lys Glu Val Val Asp Met Lys Ser Glu Gly Gln 
            660                 665                 670         


Ala Thr Val Ile Gln Gln Leu Glu Gln Thr Ile Glu Asp Leu Arg Thr 
        675                 680                 685             


Lys Ile Ala Glu Leu Glu Arg Gln Tyr Pro Ala Leu Asp Thr Glu Val 
    690                 695                 700                 


Ala Ser Gly His Gln Gly Leu Glu Asn Gly Val Thr Ala Ser Gly Asp 
705                 710                 715                 720 


Val Cys Leu Glu Ala Leu Arg Leu Glu Glu Lys Glu Val Arg His His 
                725                 730                 735     


Arg Ile Leu Glu Ala Lys Ser Ile Gln Thr Ser Pro Thr Glu Glu Gly 
            740                 745                 750         


Gly Val Leu Thr Leu Pro Pro Val Asp Gly Leu Pro Gly Arg Pro Pro 
        755                 760                 765             


Cys Pro Pro Gly Ala Glu Ser Gly Pro Gln Thr Lys Phe Cys Ser Glu 
    770                 775                 780                 


Ile Ser Leu Ile Val Ser Pro Arg Arg Ile Ser Val Gln Leu Asp Ser 
785                 790                 795                 800 


His Gln Pro Thr Gln Ser Ile Ser Gln Pro Pro Pro Pro Pro Ser Leu 
                805                 810                 815     


Leu Trp Ser Ala Gly Gln Gly Gln Pro Gly Ser Gln Pro Pro His Ser 
            820                 825                 830         


Ile Ser Thr Glu Phe Gln Thr Ser His Glu His Ser Val Ser Ser Ala 
        835                 840                 845             


Phe Lys Asn Ser Cys Asn Ile Pro Ser Pro Pro Pro Leu Pro Cys Thr 
    850                 855                 860                 


Glu Ser Ser Ser Ser Met Pro Gly Leu Gly Met Val Pro Pro Pro Pro 
865                 870                 875                 880 


Pro Pro Leu Pro Gly Met Thr Val Pro Thr Leu Pro Ser Thr Ala Ile 
                885                 890                 895     


Pro Gln Pro Pro Pro Leu Gln Gly Thr Glu Met Leu Pro Pro Pro Pro 
            900                 905                 910         


Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly 
        915                 920                 925             


Ala Gly Ile Leu Pro Leu Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro 
    930                 935                 940                 


Pro Pro Pro Leu Pro Gly Ala Ala Ile Pro Pro Pro Pro Pro Leu Pro 
945                 950                 955                 960 


Gly Ala Gly Ile Pro Leu Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro 
                965                 970                 975     


Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro Pro Leu 
            980                 985                 990         


Pro Gly Ala Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile 
        995                 1000                 1005             


Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro 
    1010                 1015                 1020             


Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1025                 1030                 1035             


Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro 
    1040                 1045                 1050             


Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro 
    1055                 1060                 1065             


Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala 
    1070                 1075                 1080             


Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro 
    1085                 1090                 1095             


Pro Pro  Pro Leu Pro Gly Val  Gly Ile Pro Pro Pro  Pro Pro Leu 
    1100                 1105                 1110             


Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly 
    1115                 1120                 1125             


Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro 
    1130                 1135                 1140             


Pro Pro  Leu Pro Arg Val Gly  Ile Pro Pro Pro Pro  Pro Leu Pro 
    1145                 1150                 1155             


Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile 
    1160                 1165                 1170             


Pro Pro  Pro Pro Pro Leu Pro  Gly Val Gly Ile Pro  Pro Pro Pro 
    1175                 1180                 1185             


Pro Leu  Pro Gly Val Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1190                 1195                 1200             


Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro Gly Met  Gly Ile Pro 
    1205                 1210                 1215             


Pro Ala  Pro Ala Pro Pro Leu  Pro Pro Pro Gly Thr  Gly Ile Pro 
    1220                 1225                 1230             


Pro Pro  Pro Leu Leu Pro Val  Ser Gly Pro Pro Leu  Leu Pro Gln 
    1235                 1240                 1245             


Val Gly  Ser Ser Thr Leu Pro  Thr Pro Gln Val Cys  Gly Phe Leu 
    1250                 1255                 1260             


Pro Pro  Pro Leu Pro Ser Gly  Leu Phe Gly Leu Gly  Met Asn Gln 
    1265                 1270                 1275             


Asp Lys  Gly Ser Arg Lys Gln  Pro Ile Glu Pro Cys  Arg Pro Met 
    1280                 1285                 1290             


Lys Pro  Leu Tyr Trp Thr Arg  Ile Gln Leu His Ser  Lys Arg Asp 
    1295                 1300                 1305             


Ser Ser  Thr Ser Leu Ile Trp  Glu Lys Ile Glu Glu  Pro Ser Ile 
    1310                 1315                 1320             


Asp Cys  His Glu Phe Glu Glu  Leu Phe Ser Lys Thr  Ala Val Lys 
    1325                 1330                 1335             


Glu Arg  Lys Lys Pro Ile Ser  Asp Thr Ile Ser Lys  Thr Lys Ala 
    1340                 1345                 1350             


Lys Gln  Val Val Lys Leu Leu  Ser Asn Lys Arg Ser  Gln Ala Val 
    1355                 1360                 1365             


Gly Ile  Leu Met Ser Ser Leu  His Leu Asp Met Lys  Asp Ile Gln 
    1370                 1375                 1380             


His Ala  Val Val Asn Leu Asp  Asn Ser Val Val Asp  Leu Glu Thr 
    1385                 1390                 1395             


Leu Gln  Ala Leu Tyr Glu Asn  Arg Ala Gln Ser Asp  Glu Leu Glu 
    1400                 1405                 1410             


Lys Ile  Glu Lys His Gly Arg  Ser Ser Lys Asp Lys  Glu Asn Ala 
    1415                 1420                 1425             


Lys Ser  Leu Asp Lys Pro Glu  Gln Phe Leu Tyr Glu  Leu Ser Leu 
    1430                 1435                 1440             


Ile Pro  Asn Phe Ser Glu Arg  Val Phe Cys Ile Leu  Phe Gln Ser 
    1445                 1450                 1455             


Thr Phe  Ser Glu Ser Ile Cys  Ser Ile Arg Arg Lys  Leu Glu Leu 
    1460                 1465                 1470             


Leu Gln  Lys Leu Cys Glu Thr  Leu Lys Asn Gly Pro  Gly Val Met 
    1475                 1480                 1485             


Gln Val  Leu Gly Leu Val Leu  Ala Phe Gly Asn Tyr  Met Asn Gly 
    1490                 1495                 1500             


Gly Asn  Lys Thr Arg Gly Gln  Ala Asp Gly Phe Gly  Leu Asp Ile 
    1505                 1510                 1515             


Leu Pro  Lys Leu Lys Asp Val  Lys Ser Ser Asp Asn  Ser Arg Ser 
    1520                 1525                 1530             


Leu Leu  Ser Tyr Ile Val Ser  Tyr Tyr Leu Arg Asn  Phe Asp Glu 
    1535                 1540                 1545             


Asp Ala  Gly Lys Glu Gln Cys  Leu Phe Pro Leu Pro  Glu Pro Gln 
    1550                 1555                 1560             


Asp Leu  Phe Gln Ala Ser Gln  Met Lys Phe Glu Asp  Phe Gln Lys 
    1565                 1570                 1575             


Asp Leu  Arg Lys Leu Lys Lys  Asp Leu Lys Ala Cys  Glu Val Glu 
    1580                 1585                 1590             


Ala Gly  Lys Val Tyr Gln Val  Ser Ser Lys Glu His  Met Gln Pro 
    1595                 1600                 1605             


Phe Lys  Glu Asn Met Glu Gln  Phe Ile Ile Gln Ala  Lys Ile Asp 
    1610                 1615                 1620             


Gln Glu  Ala Glu Glu Asn Ser  Leu Thr Glu Thr His  Lys Cys Phe 
    1625                 1630                 1635             


Leu Glu  Thr Thr Ala Tyr Phe  Phe Met Lys Pro Lys  Leu Gly Glu 
    1640                 1645                 1650             


Lys Glu  Val Ser Pro Asn Ala  Phe Phe Ser Ile Trp  His Glu Phe 
    1655                 1660                 1665             


Ser Ser  Asp Phe Lys Asp Phe  Trp Lys Lys Glu Asn  Lys Leu Leu 
    1670                 1675                 1680             


Leu Gln  Glu Arg Val Lys Glu  Ala Glu Glu Val Cys  Arg Gln Lys 
    1685                 1690                 1695             


Lys Gly  Lys Ser Leu Tyr Lys  Ile Lys Pro Arg His  Asp Ser Gly 
    1700                 1705                 1710             


Ile Lys  Ala Lys Ile Ser Met  Lys Thr 
    1715                 1720         


<210>  4104
<211>  1100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMNL1__Homo_sapiens__NP_005883

<400>  4104

Met Gly Asn Ala Ala Gly Ser Ala Glu Gln Pro Ala Gly Pro Ala Ala 
1               5                   10                  15      


Pro Pro Pro Lys Gln Pro Ala Pro Pro Lys Gln Pro Met Pro Ala Ala 
            20                  25                  30          


Gly Glu Leu Glu Glu Arg Phe Asn Arg Ala Leu Asn Cys Met Asn Leu 
        35                  40                  45              


Pro Pro Asp Lys Val Gln Leu Leu Ser Gln Tyr Asp Asn Glu Lys Lys 
    50                  55                  60                  


Trp Glu Leu Ile Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro 
65                  70                  75                  80  


Ala Ala Tyr Ile Gln Lys Leu Lys Ser Tyr Val Asp Thr Gly Gly Val 
                85                  90                  95      


Ser Arg Lys Val Ala Ala Asp Trp Met Ser Asn Leu Gly Phe Lys Arg 
            100                 105                 110         


Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Thr Ser Leu 
        115                 120                 125             


Arg Thr Asn His Ile Gly Trp Val Gln Glu Phe Leu Asn Glu Glu Asn 
    130                 135                 140                 


Arg Gly Leu Asp Val Leu Leu Glu Tyr Leu Ala Phe Ala Gln Cys Ser 
145                 150                 155                 160 


Val Thr Tyr Asp Met Glu Ser Thr Asp Asn Gly Ala Ser Asn Ser Glu 
                165                 170                 175     


Lys Asn Lys Pro Leu Glu Gln Ser Val Glu Asp Leu Ser Lys Gly Pro 
            180                 185                 190         


Pro Ser Ser Val Pro Lys Ser Arg His Leu Thr Ile Lys Leu Thr Pro 
        195                 200                 205             


Ala His Ser Arg Lys Ala Leu Arg Asn Ser Arg Ile Val Ser Gln Lys 
    210                 215                 220                 


Asp Asp Val His Val Cys Ile Met Cys Leu Arg Ala Ile Met Asn Tyr 
225                 230                 235                 240 


Gln Ser Gly Phe Ser Leu Val Met Asn His Pro Ala Cys Val Asn Glu 
                245                 250                 255     


Ile Ala Leu Ser Leu Asn Asn Lys Asn Pro Arg Thr Lys Ala Leu Val 
            260                 265                 270         


Leu Glu Leu Leu Ala Ala Val Cys Leu Val Arg Gly Gly His Asp Ile 
        275                 280                 285             


Ile Leu Ala Ala Phe Asp Asn Phe Lys Glu Val Cys Gly Glu Gln His 
    290                 295                 300                 


Arg Phe Glu Lys Leu Met Glu Tyr Phe Arg Asn Glu Asp Ser Asn Ile 
305                 310                 315                 320 


Asp Phe Met Val Ala Cys Met Gln Phe Ile Asn Ile Val Val His Ser 
                325                 330                 335     


Val Glu Asn Met Asn Phe Arg Val Phe Leu Gln Tyr Glu Phe Thr His 
            340                 345                 350         


Leu Gly Leu Asp Leu Tyr Leu Glu Arg Leu Arg Leu Thr Glu Ser Asp 
        355                 360                 365             


Lys Leu Gln Val Gln Ile Gln Ala Tyr Leu Asp Asn Ile Phe Asp Val 
    370                 375                 380                 


Gly Ala Leu Leu Glu Asp Thr Glu Thr Lys Asn Ala Val Leu Glu His 
385                 390                 395                 400 


Met Glu Glu Leu Gln Glu Gln Val Ala Leu Leu Thr Glu Arg Leu Arg 
                405                 410                 415     


Asp Ala Glu Asn Glu Ser Met Ala Lys Ile Ala Glu Leu Glu Lys Gln 
            420                 425                 430         


Leu Ser Gln Ala Arg Lys Glu Leu Glu Thr Leu Arg Glu Arg Phe Ser 
        435                 440                 445             


Glu Ser Thr Ala Met Gly Ala Ser Arg Arg Pro Pro Glu Pro Glu Lys 
    450                 455                 460                 


Ala Pro Pro Ala Ala Pro Thr Arg Pro Ser Ala Leu Glu Leu Lys Val 
465                 470                 475                 480 


Glu Glu Leu Glu Glu Lys Gly Leu Ile Arg Ile Leu Arg Gly Pro Gly 
                485                 490                 495     


Asp Ala Val Ser Ile Glu Ile Leu Pro Val Ala Val Ala Thr Pro Ser 
            500                 505                 510         


Gly Gly Asp Ala Pro Thr Pro Gly Val Pro Thr Gly Ser Pro Ser Pro 
        515                 520                 525             


Asp Leu Ala Pro Ala Ala Glu Pro Ala Pro Gly Ala Ala Pro Pro Pro 
    530                 535                 540                 


Pro Pro Pro Leu Pro Gly Leu Pro Ser Pro Gln Glu Ala Pro Pro Ser 
545                 550                 555                 560 


Ala Pro Pro Gln Ala Pro Pro Leu Pro Gly Ser Pro Glu Pro Pro Pro 
                565                 570                 575     


Ala Pro Pro Leu Pro Gly Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            580                 585                 590         


Pro Pro Pro Gly Thr Asp Gly Pro Val Pro Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Pro Pro Pro Pro Gly Gly Pro Pro Asp Ala Leu Gly Arg Arg Asp Ser 
    610                 615                 620                 


Glu Leu Gly Pro Gly Val Lys Ala Lys Lys Pro Ile Gln Thr Lys Phe 
625                 630                 635                 640 


Arg Met Pro Leu Leu Asn Trp Val Ala Leu Lys Pro Ser Gln Ile Thr 
                645                 650                 655     


Gly Thr Val Phe Thr Glu Leu Asn Asp Glu Lys Val Leu Gln Glu Leu 
            660                 665                 670         


Asp Met Ser Asp Phe Glu Glu Gln Phe Lys Thr Lys Ser Gln Gly Pro 
        675                 680                 685             


Ser Leu Asp Leu Ser Ala Leu Lys Ser Lys Ala Ala Gln Lys Ala Pro 
    690                 695                 700                 


Ser Lys Ala Thr Leu Ile Glu Ala Asn Arg Ala Lys Asn Leu Ala Ile 
705                 710                 715                 720 


Thr Leu Arg Lys Gly Asn Leu Gly Ala Glu Arg Ile Cys Gln Ala Ile 
                725                 730                 735     


Glu Ala Tyr Asp Leu Gln Ala Leu Gly Leu Asp Phe Leu Glu Leu Leu 
            740                 745                 750         


Met Arg Phe Leu Pro Thr Glu Tyr Glu Arg Ser Leu Ile Thr Arg Phe 
        755                 760                 765             


Glu Arg Glu Gln Arg Pro Met Glu Glu Leu Ser Glu Glu Asp Arg Phe 
    770                 775                 780                 


Met Leu Cys Phe Ser Arg Ile Pro Arg Leu Pro Glu Arg Met Thr Thr 
785                 790                 795                 800 


Leu Thr Phe Leu Gly Asn Phe Pro Asp Thr Ala Gln Leu Leu Met Pro 
                805                 810                 815     


Gln Leu Asn Ala Ile Ile Ala Ala Ser Met Ser Ile Lys Ser Ser Asp 
            820                 825                 830         


Lys Leu Arg Gln Ile Leu Glu Ile Val Leu Ala Phe Gly Asn Tyr Met 
        835                 840                 845             


Asn Ser Ser Lys Arg Gly Ala Ala Tyr Gly Phe Arg Leu Gln Ser Leu 
    850                 855                 860                 


Asp Ala Leu Leu Glu Met Lys Ser Thr Asp Arg Lys Gln Thr Leu Leu 
865                 870                 875                 880 


His Tyr Leu Val Lys Val Ile Ala Glu Lys Tyr Pro Gln Leu Thr Gly 
                885                 890                 895     


Phe His Ser Asp Leu His Phe Leu Asp Lys Ala Gly Ser Val Ser Leu 
            900                 905                 910         


Asp Ser Val Leu Ala Asp Val Arg Ser Leu Gln Arg Gly Leu Glu Leu 
        915                 920                 925             


Thr Gln Arg Glu Phe Val Arg Gln Asp Asp Cys Met Val Leu Lys Glu 
    930                 935                 940                 


Phe Leu Arg Ala Asn Ser Pro Thr Met Asp Lys Leu Leu Ala Asp Ser 
945                 950                 955                 960 


Lys Thr Ala Gln Glu Ala Phe Glu Ser Val Val Glu Tyr Phe Gly Glu 
                965                 970                 975     


Asn Pro Lys Thr Thr Ser Pro Gly Leu Phe Phe Ser Leu Phe Ser Arg 
            980                 985                 990         


Phe Ile Lys Ala Tyr Lys Lys Ala  Glu Gln Glu Val Glu  Gln Trp Lys 
        995                 1000                 1005             


Lys Glu  Ala Ala Ala Gln Glu  Ala Gly Ala Asp Thr  Pro Gly Lys 
    1010                 1015                 1020             


Gly Glu  Pro Pro Ala Pro Lys  Ser Pro Pro Lys Ala  Arg Arg Pro 
    1025                 1030                 1035             


Gln Met  Asp Leu Ile Ser Glu  Leu Lys Arg Arg Gln  Gln Lys Glu 
    1040                 1045                 1050             


Pro Leu  Ile Tyr Glu Ser Asp  Arg Asp Gly Ala Ile  Glu Asp Ile 
    1055                 1060                 1065             


Ile Thr  Val Ile Lys Thr Val  Pro Phe Thr Ala Arg  Thr Gly Lys 
    1070                 1075                 1080             


Arg Thr  Ser Arg Leu Leu Cys  Glu Ala Ser Leu Gly  Glu Glu Met 
    1085                 1090                 1095             


Pro Leu  
    1100 


<210>  4105
<211>  1092
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMNL2__Homo_sapiens__NP_443137

<400>  4105

Met Gly Asn Ala Gly Ser Met Asp Ser Gln Gln Thr Asp Phe Arg Ala 
1               5                   10                  15      


His Asn Val Pro Leu Lys Leu Pro Met Pro Glu Pro Gly Glu Leu Glu 
            20                  25                  30          


Glu Arg Phe Ala Ile Val Leu Asn Ala Met Asn Leu Pro Pro Asp Lys 
        35                  40                  45              


Ala Arg Leu Leu Arg Gln Tyr Asp Asn Glu Lys Lys Trp Glu Leu Ile 
    50                  55                  60                  


Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro His Thr Tyr Ile 
65                  70                  75                  80  


Gln Lys Leu Lys Gly Tyr Leu Asp Pro Ala Val Thr Arg Lys Lys Phe 
                85                  90                  95      


Arg Arg Arg Val Gln Glu Ser Thr Gln Val Leu Arg Glu Leu Glu Ile 
            100                 105                 110         


Ser Leu Arg Thr Asn His Ile Gly Trp Val Arg Glu Phe Leu Asn Glu 
        115                 120                 125             


Glu Asn Lys Gly Leu Asp Val Leu Val Glu Tyr Leu Ser Phe Ala Gln 
    130                 135                 140                 


Tyr Ala Val Thr Phe Asp Phe Glu Ser Val Glu Ser Thr Val Glu Ser 
145                 150                 155                 160 


Ser Val Asp Lys Ser Lys Pro Trp Ser Arg Ser Ile Glu Asp Leu His 
                165                 170                 175     


Arg Gly Ser Asn Leu Pro Ser Pro Val Gly Asn Ser Val Ser Arg Ser 
            180                 185                 190         


Gly Arg His Ser Ala Leu Arg Tyr Asn Thr Leu Pro Ser Arg Arg Thr 
        195                 200                 205             


Leu Lys Asn Ser Arg Leu Val Ser Lys Lys Asp Asp Val His Val Cys 
    210                 215                 220                 


Ile Met Cys Leu Arg Ala Ile Met Asn Tyr Gln Tyr Gly Phe Asn Met 
225                 230                 235                 240 


Val Met Ser His Pro His Ala Val Asn Glu Ile Ala Leu Ser Leu Asn 
                245                 250                 255     


Asn Lys Asn Pro Arg Thr Lys Ala Leu Val Leu Glu Leu Leu Ala Ala 
            260                 265                 270         


Val Cys Leu Val Arg Gly Gly His Glu Ile Ile Leu Ser Ala Phe Asp 
        275                 280                 285             


Asn Phe Lys Glu Val Cys Gly Glu Lys Gln Arg Phe Glu Lys Leu Met 
    290                 295                 300                 


Glu His Phe Arg Asn Glu Asp Asn Asn Ile Asp Phe Met Val Ala Ser 
305                 310                 315                 320 


Met Gln Phe Ile Asn Ile Val Val His Ser Val Glu Asp Met Asn Phe 
                325                 330                 335     


Arg Val His Leu Gln Tyr Glu Phe Thr Lys Leu Gly Leu Asp Glu Tyr 
            340                 345                 350         


Leu Asp Lys Leu Lys His Thr Glu Ser Asp Lys Leu Gln Val Gln Ile 
        355                 360                 365             


Gln Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Ala Leu Leu Glu Asp 
    370                 375                 380                 


Ala Glu Thr Lys Asn Ala Ala Leu Glu Arg Val Glu Glu Leu Glu Glu 
385                 390                 395                 400 


Asn Ile Ser His Leu Ser Glu Lys Leu Gln Asp Thr Glu Asn Glu Ala 
                405                 410                 415     


Met Ser Lys Ile Val Glu Leu Glu Lys Gln Leu Met Gln Arg Asn Lys 
            420                 425                 430         


Glu Leu Asp Val Val Arg Glu Ile Tyr Lys Asp Ala Asn Thr Gln Val 
        435                 440                 445             


His Thr Leu Arg Lys Met Val Lys Glu Lys Glu Glu Ala Ile Gln Arg 
    450                 455                 460                 


Gln Ser Thr Leu Glu Lys Lys Ile His Glu Leu Glu Lys Gln Gly Thr 
465                 470                 475                 480 


Ile Lys Ile Gln Lys Lys Gly Asp Gly Asp Ile Ala Ile Leu Pro Val 
                485                 490                 495     


Val Ala Ser Gly Thr Leu Ser Met Gly Ser Glu Val Val Ala Gly Asn 
            500                 505                 510         


Ser Val Gly Pro Thr Met Gly Ala Ala Ser Ser Gly Pro Leu Pro Pro 
        515                 520                 525             


Pro Pro Pro Pro Leu Pro Pro Ser Ser Asp Thr Pro Glu Thr Val Gln 
    530                 535                 540                 


Asn Gly Pro Val Thr Pro Pro Met Pro Pro Pro Pro Pro Pro Pro Pro 
545                 550                 555                 560 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly 
                565                 570                 575     


Pro Ala Ala Glu Thr Val Pro Ala Pro Pro Leu Ala Pro Pro Leu Pro 
            580                 585                 590         


Ser Ala Pro Pro Leu Pro Gly Thr Ser Ser Pro Thr Val Val Phe Asn 
        595                 600                 605             


Ser Gly Leu Ala Ala Val Lys Ile Lys Lys Pro Ile Lys Thr Lys Phe 
    610                 615                 620                 


Arg Met Pro Val Phe Asn Trp Val Ala Leu Lys Pro Asn Gln Ile Asn 
625                 630                 635                 640 


Gly Thr Val Phe Asn Glu Ile Asp Asp Glu Arg Ile Leu Glu Asp Leu 
                645                 650                 655     


Asn Val Asp Glu Phe Glu Glu Ile Phe Lys Thr Lys Ala Gln Gly Pro 
            660                 665                 670         


Ala Ile Asp Leu Ser Ser Ser Lys Gln Lys Ile Pro Gln Lys Gly Ser 
        675                 680                 685             


Asn Lys Val Thr Leu Leu Glu Ala Asn Arg Ala Lys Asn Leu Ala Ile 
    690                 695                 700                 


Thr Leu Arg Lys Ala Gly Lys Thr Ala Asp Glu Ile Cys Lys Ala Ile 
705                 710                 715                 720 


His Val Phe Asp Leu Lys Thr Leu Pro Val Asp Phe Val Glu Cys Leu 
                725                 730                 735     


Met Arg Phe Leu Pro Thr Glu Asn Glu Val Lys Val Leu Arg Leu Tyr 
            740                 745                 750         


Glu Arg Glu Arg Lys Pro Leu Glu Asn Leu Ser Asp Glu Asp Arg Phe 
        755                 760                 765             


Met Met Gln Phe Ser Lys Ile Glu Arg Leu Met Gln Lys Met Thr Ile 
    770                 775                 780                 


Met Ala Phe Ile Gly Asn Phe Ala Glu Ser Ile Gln Met Leu Thr Pro 
785                 790                 795                 800 


Gln Leu His Ala Ile Ile Ala Ala Ser Val Ser Ile Lys Ser Ser Gln 
                805                 810                 815     


Lys Leu Lys Lys Ile Leu Glu Ile Ile Leu Ala Leu Gly Asn Tyr Met 
            820                 825                 830         


Asn Ser Ser Lys Arg Gly Ala Val Tyr Gly Phe Lys Leu Gln Ser Leu 
        835                 840                 845             


Asp Leu Leu Leu Asp Thr Lys Ser Thr Asp Arg Lys Gln Thr Leu Leu 
    850                 855                 860                 


His Tyr Ile Ser Asn Val Val Lys Glu Lys Tyr His Gln Val Ser Leu 
865                 870                 875                 880 


Phe Tyr Asn Glu Leu His Tyr Val Glu Lys Ala Ala Ala Val Ser Leu 
                885                 890                 895     


Glu Asn Val Leu Leu Asp Val Lys Glu Leu Gln Arg Gly Met Asp Leu 
            900                 905                 910         


Thr Lys Arg Glu Tyr Thr Met His Asp His Asn Thr Leu Leu Lys Glu 
        915                 920                 925             


Phe Ile Leu Asn Asn Glu Gly Lys Leu Lys Lys Leu Gln Asp Asp Ala 
    930                 935                 940                 


Lys Ile Ala Gln Asp Ala Phe Asp Asp Val Val Lys Tyr Phe Gly Glu 
945                 950                 955                 960 


Asn Pro Lys Thr Thr Pro Pro Ser Val Phe Phe Pro Val Phe Val Arg 
                965                 970                 975     


Phe Val Lys Ala Tyr Lys Gln Ala Glu Glu Glu Asn Glu Leu Arg Lys 
            980                 985                 990         


Lys Gln Glu Gln Ala Leu Met Glu  Lys Leu Leu Glu Gln  Glu Ala Leu 
        995                 1000                 1005             


Met Glu  Gln Gln Asp Pro Lys  Ser Pro Ser His Lys  Ser Lys Arg 
    1010                 1015                 1020             


Gln Gln  Gln Glu Leu Ile Ala  Glu Leu Arg Arg Arg  Gln Val Lys 
    1025                 1030                 1035             


Asp Asn  Arg His Val Tyr Glu  Gly Lys Asp Gly Ala  Ile Glu Asp 
    1040                 1045                 1050             


Ile Ile  Thr Asp Leu Arg Asn  Gln Pro Tyr Arg Arg  Ala Asp Ala 
    1055                 1060                 1065             


Val Arg  Arg Ser Val Arg Arg  Arg Phe Asp Asp Gln  Asn Leu Arg 
    1070                 1075                 1080             


Ser Val  Asn Gly Ala Glu Ile  Thr Met 
    1085                 1090         


<210>  4106
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMNL3__Homo_sapiens__NP_783863

<400>  4106

Met Gly Asn Leu Glu Ser Ala Glu Gly Val Pro Gly Glu Pro Pro Ser 
1               5                   10                  15      


Val Pro Leu Leu Leu Pro Pro Gly Lys Met Pro Met Pro Glu Pro Cys 
            20                  25                  30          


Glu Leu Glu Glu Arg Phe Ala Leu Val Leu Ser Ser Met Asn Leu Pro 
        35                  40                  45              


Pro Asp Lys Ala Arg Leu Leu Arg Gln Tyr Asp Asn Glu Lys Lys Trp 
    50                  55                  60                  


Asp Leu Ile Cys Asp Gln Glu Arg Phe Gln Val Lys Asn Pro Pro His 
65                  70                  75                  80  


Thr Tyr Ile Gln Lys Leu Gln Ser Phe Leu Asp Pro Ser Val Thr Arg 
                85                  90                  95      


Lys Lys Phe Arg Arg Arg Val Gln Glu Ser Thr Lys Val Leu Arg Glu 
            100                 105                 110         


Leu Glu Ile Ser Leu Arg Thr Asn His Ile Gly Trp Val Arg Glu Phe 
        115                 120                 125             


Leu Asn Asp Glu Asn Lys Gly Leu Asp Val Leu Val Asp Tyr Leu Ser 
    130                 135                 140                 


Phe Ala Gln Cys Ser Val Met Phe Asp Phe Glu Gly Leu Glu Ser Gly 
145                 150                 155                 160 


Asp Asp Gly Ala Phe Asp Lys Leu Arg Ser Trp Ser Arg Ser Ile Glu 
                165                 170                 175     


Asp Leu Gln Pro Pro Ser Ala Leu Ser Ala Pro Phe Thr Asn Ser Leu 
            180                 185                 190         


Ala Arg Ser Ala Arg Gln Ser Val Leu Arg Tyr Ser Thr Leu Pro Gly 
        195                 200                 205             


Arg Arg Ala Leu Lys Asn Ser Arg Leu Val Ser Gln Lys Asp Asp Val 
    210                 215                 220                 


His Val Cys Ile Leu Cys Leu Arg Ala Ile Met Asn Tyr Gln Tyr Gly 
225                 230                 235                 240 


Phe Asn Leu Val Met Ser His Pro His Ala Val Asn Glu Ile Ala Leu 
                245                 250                 255     


Ser Leu Asn Asn Lys Asn Pro Arg Thr Lys Ala Leu Val Leu Glu Leu 
            260                 265                 270         


Leu Ala Ala Val Cys Leu Val Arg Gly Gly His Glu Ile Ile Leu Ala 
        275                 280                 285             


Ala Phe Asp Asn Phe Lys Glu Val Cys Lys Glu Leu His Arg Phe Glu 
    290                 295                 300                 


Lys Leu Met Glu Tyr Phe Arg Asn Glu Asp Ser Asn Ile Asp Phe Met 
305                 310                 315                 320 


Val Ala Cys Met Gln Phe Ile Asn Ile Val Val His Ser Val Glu Asp 
                325                 330                 335     


Met Asn Phe Arg Val His Leu Gln Tyr Glu Phe Thr Lys Leu Gly Leu 
            340                 345                 350         


Glu Glu Phe Leu Gln Lys Ser Arg His Thr Glu Ser Glu Lys Leu Gln 
        355                 360                 365             


Val Gln Ile Gln Ala Tyr Leu Asp Asn Val Phe Asp Val Gly Gly Leu 
    370                 375                 380                 


Leu Glu Asp Ala Glu Thr Lys Asn Val Ala Leu Glu Lys Val Glu Glu 
385                 390                 395                 400 


Leu Glu Glu His Val Ser His Leu Thr Glu Lys Leu Leu Asp Leu Glu 
                405                 410                 415     


Asn Glu Asn Met Met Arg Val Ala Glu Leu Glu Lys Gln Leu Leu Gln 
            420                 425                 430         


Arg Glu Lys Glu Leu Glu Ser Ile Lys Glu Thr Tyr Glu Asn Thr Ser 
        435                 440                 445             


His Gln Val His Thr Leu Arg Arg Leu Ile Lys Glu Lys Glu Glu Ala 
    450                 455                 460                 


Phe Gln Arg Arg Cys His Leu Glu Pro Asn Val Arg Gly Leu Glu Ser 
465                 470                 475                 480 


Val Asp Ser Glu Ala Leu Ala Arg Val Gly Pro Ala Glu Leu Ser Glu 
                485                 490                 495     


Gly Met Pro Pro Ser Asp Leu Asp Leu Leu Ala Pro Ala Pro Pro Pro 
            500                 505                 510         


Glu Glu Val Leu Pro Leu Pro Pro Pro Pro Ala Pro Pro Leu Pro Pro 
        515                 520                 525             


Pro Pro Pro Pro Leu Pro Asp Lys Cys Pro Pro Ala Pro Pro Leu Pro 
    530                 535                 540                 


Gly Ala Ala Pro Ser Val Val Leu Thr Val Gly Leu Ser Ala Ile Arg 
545                 550                 555                 560 


Ile Lys Lys Pro Ile Lys Thr Lys Phe Arg Leu Pro Val Phe Asn Trp 
                565                 570                 575     


Thr Ala Leu Lys Pro Asn Gln Ile Ser Gly Thr Val Phe Ser Glu Leu 
            580                 585                 590         


Asp Asp Glu Lys Ile Leu Glu Asp Leu Asp Leu Asp Lys Phe Glu Glu 
        595                 600                 605             


Leu Phe Lys Thr Lys Ala Gln Gly Pro Ala Leu Asp Leu Ile Cys Ser 
    610                 615                 620                 


Lys Asn Lys Thr Ala Gln Lys Ala Ala Ser Lys Val Thr Leu Leu Glu 
625                 630                 635                 640 


Ala Asn Arg Ala Lys Asn Leu Ala Ile Thr Leu Arg Lys Ala Gly Arg 
                645                 650                 655     


Ser Ala Glu Glu Ile Cys Arg Ala Ile His Thr Phe Asp Leu Gln Thr 
            660                 665                 670         


Leu Pro Val Asp Phe Val Glu Cys Leu Met Arg Phe Leu Pro Thr Glu 
        675                 680                 685             


Ala Glu Val Lys Leu Leu Arg Gln Tyr Glu Arg Glu Arg Gln Pro Leu 
    690                 695                 700                 


Glu Glu Leu Ala Ala Glu Asp Arg Phe Met Leu Leu Phe Ser Lys Val 
705                 710                 715                 720 


Glu Arg Leu Thr Gln Arg Met Ala Gly Met Ala Phe Leu Gly Asn Phe 
                725                 730                 735     


Gln Asp Asn Leu Gln Met Leu Thr Pro Gln Leu Asn Ala Ile Ile Ala 
            740                 745                 750         


Ala Ser Ala Ser Val Lys Ser Ser Gln Lys Leu Lys Gln Met Leu Glu 
        755                 760                 765             


Ile Ile Leu Ala Leu Gly Asn Tyr Met Asn Ser Ser Lys Arg Gly Ala 
    770                 775                 780                 


Val Tyr Gly Phe Lys Leu Gln Ser Leu Asp Leu Leu Leu Asp Thr Lys 
785                 790                 795                 800 


Ser Thr Asp Arg Lys Met Thr Leu Leu His Phe Ile Ala Leu Thr Val 
                805                 810                 815     


Lys Glu Lys Tyr Pro Asp Leu Ala Asn Phe Trp His Glu Leu His Phe 
            820                 825                 830         


Val Glu Lys Ala Ala Ala Val Ser Leu Glu Asn Val Leu Leu Asp Val 
        835                 840                 845             


Lys Glu Leu Gly Arg Gly Met Glu Leu Ile Arg Arg Glu Cys Ser Ile 
    850                 855                 860                 


His Asp Asn Ser Val Leu Arg Asn Phe Leu Ser Thr Asn Glu Gly Lys 
865                 870                 875                 880 


Leu Asp Lys Leu Gln Arg Asp Ala Lys Thr Ala Glu Glu Ala Tyr Asn 
                885                 890                 895     


Ala Val Val Arg Tyr Phe Gly Glu Ser Pro Lys Thr Thr Pro Pro Ser 
            900                 905                 910         


Val Phe Phe Pro Val Phe Val Arg Phe Ile Arg Ser Tyr Lys Glu Ala 
        915                 920                 925             


Glu Gln Glu Asn Glu Ala Arg Lys Lys Gln Glu Glu Val Met Arg Glu 
    930                 935                 940                 


Lys Gln Leu Ala Gln Glu Ala Lys Lys Leu Asp Ala Lys Thr Pro Ser 
945                 950                 955                 960 


Gln Arg Asn Lys Trp Gln Gln Gln Glu Leu Ile Ala Glu Leu Arg Arg 
                965                 970                 975     


Arg Gln Ala Lys Glu His Arg Pro Val Tyr Glu Gly Lys Asp Gly Thr 
            980                 985                 990         


Ile Glu Asp Ile Ile Thr Gly Leu  His Cys Gln Pro Met  Val Val Arg 
        995                 1000                 1005             


His Gln  Ala Arg Ser Ala Ala  Pro Pro Ser Gly Pro  Pro Arg Ala 
    1010                 1015                 1020             


Pro Gly  Pro His 
    1025         


<210>  4107
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMO1__Homo_sapiens__NP_001269621

<400>  4107

Met Gln Glu Asn Met Ala Lys Arg Val Ala Ile Val Gly Ala Gly Val 
1               5                   10                  15      


Ser Gly Leu Ala Ser Ile Lys Cys Cys Leu Glu Glu Gly Leu Glu Pro 
            20                  25                  30          


Thr Cys Phe Glu Arg Ser Asp Asp Leu Gly Gly Leu Trp Arg Phe Thr 
        35                  40                  45              


Glu His Val Glu Glu Gly Arg Ala Ser Leu Tyr Lys Ser Val Val Ser 
    50                  55                  60                  


Asn Ser Cys Lys Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe Pro Glu 
65                  70                  75                  80  


Asp Tyr Pro Asn Tyr Val Pro Asn Ser Gln Phe Leu Glu Tyr Leu Lys 
                85                  90                  95      


Met Tyr Ala Asn His Phe Asp Leu Leu Lys His Ile Gln Phe Lys Thr 
            100                 105                 110         


Lys Val Cys Ser Val Thr Lys Cys Ser Asp Ser Ala Val Ser Gly Gln 
        115                 120                 125             


Trp Glu Val Val Thr Met His Glu Glu Lys Gln Glu Ser Ala Ile Phe 
    130                 135                 140                 


Asp Ala Val Met Val Cys Thr Gly Phe Leu Thr Asn Pro Tyr Leu Pro 
145                 150                 155                 160 


Leu Asp Ser Phe Pro Gly Ile Asn Ala Phe Lys Gly Gln Tyr Phe His 
                165                 170                 175     


Ser Arg Gln Tyr Lys His Pro Asp Ile Phe Lys Asp Lys Arg Val Leu 
            180                 185                 190         


Val Ile Gly Met Gly Asn Ser Gly Thr Asp Ile Ala Val Glu Ala Ser 
        195                 200                 205             


His Leu Ala Glu Lys Val Phe Leu Ser Thr Thr Gly Gly Gly Trp Val 
    210                 215                 220                 


Ile Ser Arg Ile Phe Asp Ser Gly Tyr Pro Trp Asp Met Val Phe Met 
225                 230                 235                 240 


Thr Arg Phe Gln Asn Met Leu Arg Asn Ser Leu Pro Thr Pro Ile Val 
                245                 250                 255     


Thr Trp Leu Met Glu Arg Lys Ile Asn Asn Trp Leu Asn His Ala Asn 
            260                 265                 270         


Tyr Gly Leu Ile Pro Glu Asp Arg Thr Gln Leu Lys Glu Phe Val Leu 
        275                 280                 285             


Asn Asp Glu Leu Pro Gly Arg Ile Ile Thr Gly Lys Val Phe Ile Arg 
    290                 295                 300                 


Pro Ser Ile Lys Glu Val Lys Glu Asn Ser Val Ile Phe Asn Asn Thr 
305                 310                 315                 320 


Ser Lys Glu Glu Pro Ile Asp Ile Ile Val Phe Ala Thr Gly Tyr Thr 
                325                 330                 335     


Phe Ala Phe Pro Phe Leu Asp Glu Ser Val Val Lys Val Glu Asp Gly 
            340                 345                 350         


Gln Ala Ser Leu Tyr Lys Tyr Ile Phe Pro Ala His Leu Gln Lys Pro 
        355                 360                 365             


Thr Leu Ala Ile Ile Gly Leu Ile Lys Pro Leu Gly Ser Met Ile Pro 
    370                 375                 380                 


Thr Gly Glu Thr Gln Ala Arg Trp Ala Val Arg Val Leu Lys Gly Val 
385                 390                 395                 400 


Asn Lys Leu Pro Pro Pro Ser Val Met Ile Glu Glu Ile Asn Ala Arg 
                405                 410                 415     


Lys Glu Asn Lys Pro Ser Trp Phe Gly Leu Cys Tyr Cys Lys Ala Leu 
            420                 425                 430         


Gln Ser Asp Tyr Ile Thr Tyr Ile Asp Glu Leu Leu Thr Tyr Ile Asn 
        435                 440                 445             


Ala Lys Pro Asn Leu Phe Ser Met Leu Leu Thr Asp Pro His Leu Ala 
    450                 455                 460                 


Leu Thr Val Phe Phe Gly Pro Cys Ser Pro Tyr Gln Phe Arg Leu Thr 
465                 470                 475                 480 


Gly Pro Gly Lys Trp Glu Gly Ala Arg Asn Ala Ile Met Thr Gln Trp 
                485                 490                 495     


Asp Arg Thr Phe Lys Val Ile Lys Ala Arg Val Val Gln Glu Ser Pro 
            500                 505                 510         


Ser Pro Phe Glu Ser Phe Leu Lys Val Phe Ser Phe Leu Ala Leu Leu 
        515                 520                 525             


Val Ala Ile Phe Leu Ile Phe Leu 
    530                 535     


<210>  4108
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMO2__Homo_sapiens__NP_001451

<400>  4108

Met Ala Lys Lys Val Ala Val Ile Gly Ala Gly Val Ser Gly Leu Ile 
1               5                   10                  15      


Ser Leu Lys Cys Cys Val Asp Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Thr Glu Asp Ile Gly Gly Val Trp Arg Phe Lys Glu Asn Val Glu 
        35                  40                  45              


Asp Gly Arg Ala Ser Ile Tyr Gln Ser Val Val Thr Asn Thr Ser Lys 
    50                  55                  60                  


Glu Met Ser Cys Phe Ser Asp Phe Pro Met Pro Glu Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Leu His Asn Ser Lys Leu Leu Glu Tyr Phe Arg Ile Phe Ala Lys 
                85                  90                  95      


Lys Phe Asp Leu Leu Lys Tyr Ile Gln Phe Gln Thr Thr Val Leu Ser 
            100                 105                 110         


Val Arg Lys Cys Pro Asp Phe Ser Ser Ser Gly Gln Trp Lys Val Val 
        115                 120                 125             


Thr Gln Ser Asn Gly Lys Glu Gln Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Ser Gly His His Ile Leu Pro His Ile Pro Leu Lys Ser Phe 
145                 150                 155                 160 


Pro Gly Met Glu Arg Phe Lys Gly Gln Tyr Phe His Ser Arg Gln Tyr 
                165                 170                 175     


Lys His Pro Asp Gly Phe Glu Gly Lys Arg Ile Leu Val Ile Gly Met 
            180                 185                 190         


Gly Asn Ser Gly Ser Asp Ile Ala Val Glu Leu Ser Lys Asn Ala Ala 
        195                 200                 205             


Gln Val Phe Ile Ser Thr Arg His Gly Thr Trp Val Met Ser Arg Ile 
    210                 215                 220                 


Ser Glu Asp Gly Tyr Pro Trp Asp Ser Val Phe His Thr Arg Phe Arg 
225                 230                 235                 240 


Ser Met Leu Arg Asn Val Leu Pro Arg Thr Ala Val Lys Trp Met Ile 
                245                 250                 255     


Glu Gln Gln Met Asn Arg Trp Phe Asn His Glu Asn Tyr Gly Leu Glu 
            260                 265                 270         


Pro Gln Asn Lys Tyr Ile Met Lys Glu Pro Val Leu Asn Asp Asp Val 
        275                 280                 285             


Pro Ser Arg Leu Leu Cys Gly Ala Ile Lys Val Lys Ser Thr Val Lys 
    290                 295                 300                 


Glu Leu Thr Glu Thr Ser Ala Ile Phe Glu Asp Gly Thr Val Glu Glu 
305                 310                 315                 320 


Asn Ile Asp Val Ile Ile Phe Ala Thr Gly Tyr Ser Phe Ser Phe Pro 
                325                 330                 335     


Phe Leu Glu Asp Ser Leu Val Lys Val Glu Asn Asn Met Val Ser Leu 
            340                 345                 350         


Tyr Lys Tyr Ile Phe Pro Ala His Leu Asp Lys Ser Thr Leu Ala Cys 
        355                 360                 365             


Ile Gly Leu Ile Gln Pro Leu Gly Ser Ile Phe Pro Thr Ala Glu Leu 
    370                 375                 380                 


Gln Ala Arg Trp Val Thr Arg Val Phe Lys Gly Leu Cys Ser Leu Pro 
385                 390                 395                 400 


Ser Glu Arg Thr Met Met Met Asp Ile Ile Lys Arg Asn Glu Lys Arg 
                405                 410                 415     


Ile Asp Leu Phe Gly Glu Ser Gln Ser Gln Thr Leu Gln Thr Asn Tyr 
            420                 425                 430         


Val Asp Tyr Leu Asp Glu Leu Ala Leu Glu Ile Gly Ala Lys Pro Asp 
        435                 440                 445             


Phe Cys Ser Leu Leu Phe Lys Asp Pro Lys Leu Ala Val Arg Leu Tyr 
    450                 455                 460                 


Phe Gly Pro Cys Asn Ser Tyr Gln Tyr Arg Leu Val Gly Pro Gly Gln 
465                 470                 475                 480 


Trp Glu Gly Ala Arg Asn Ala Ile Phe Thr Gln Lys Gln Arg Ile Leu 
                485                 490                 495     


Lys Pro Leu Lys Thr Arg Ala Leu Lys Asp Ser Ser Asn Phe Ser Val 
            500                 505                 510         


Ser Phe Leu Leu Lys Ile Leu Gly Leu Leu Ala Val Val Val Ala Phe 
        515                 520                 525             


Phe Cys Gln Leu Gln Trp Ser 
    530                 535 


<210>  4109
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMO3__Homo_sapiens__NP_008825

<400>  4109

Met Gly Lys Lys Val Ala Ile Ile Gly Ala Gly Val Ser Gly Leu Ala 
1               5                   10                  15      


Ser Ile Arg Ser Cys Leu Glu Glu Gly Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Lys Ser Asn Asp Ile Gly Gly Leu Trp Lys Phe Ser Asp His Ala Glu 
        35                  40                  45              


Glu Gly Arg Ala Ser Ile Tyr Lys Ser Val Phe Ser Asn Ser Ser Lys 
    50                  55                  60                  


Glu Met Met Cys Phe Pro Asp Phe Pro Phe Pro Asp Asp Phe Pro Asn 
65                  70                  75                  80  


Phe Met His Asn Ser Lys Ile Gln Glu Tyr Ile Ile Ala Phe Ala Lys 
                85                  90                  95      


Glu Lys Asn Leu Leu Lys Tyr Ile Gln Phe Lys Thr Phe Val Ser Ser 
            100                 105                 110         


Val Asn Lys His Pro Asp Phe Ala Thr Thr Gly Gln Trp Asp Val Thr 
        115                 120                 125             


Thr Glu Arg Asp Gly Lys Lys Glu Ser Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Ser Gly His His Val Tyr Pro Asn Leu Pro Lys Glu Ser Phe 
145                 150                 155                 160 


Pro Gly Leu Asn His Phe Lys Gly Lys Cys Phe His Ser Arg Asp Tyr 
                165                 170                 175     


Lys Glu Pro Gly Val Phe Asn Gly Lys Arg Val Leu Val Val Gly Leu 
            180                 185                 190         


Gly Asn Ser Gly Cys Asp Ile Ala Thr Glu Leu Ser Arg Thr Ala Glu 
        195                 200                 205             


Gln Val Met Ile Ser Ser Arg Ser Gly Ser Trp Val Met Ser Arg Val 
    210                 215                 220                 


Trp Asp Asn Gly Tyr Pro Trp Asp Met Leu Leu Val Thr Arg Phe Gly 
225                 230                 235                 240 


Thr Phe Leu Lys Asn Asn Leu Pro Thr Ala Ile Ser Asp Trp Leu Tyr 
                245                 250                 255     


Val Lys Gln Met Asn Ala Arg Phe Lys His Glu Asn Tyr Gly Leu Met 
            260                 265                 270         


Pro Leu Asn Gly Val Leu Arg Lys Glu Pro Val Phe Asn Asp Glu Leu 
        275                 280                 285             


Pro Ala Ser Ile Leu Cys Gly Ile Val Ser Val Lys Pro Asn Val Lys 
    290                 295                 300                 


Glu Phe Thr Glu Thr Ser Ala Ile Phe Glu Asp Gly Thr Ile Phe Glu 
305                 310                 315                 320 


Gly Ile Asp Cys Val Ile Phe Ala Thr Gly Tyr Ser Phe Ala Tyr Pro 
                325                 330                 335     


Phe Leu Asp Glu Ser Ile Ile Lys Ser Arg Asn Asn Glu Ile Ile Leu 
            340                 345                 350         


Phe Lys Gly Val Phe Pro Pro Leu Leu Glu Lys Ser Thr Ile Ala Val 
        355                 360                 365             


Ile Gly Phe Val Gln Ser Leu Gly Ala Ala Ile Pro Thr Val Asp Leu 
    370                 375                 380                 


Gln Ser Arg Trp Ala Ala Gln Val Ile Lys Gly Thr Cys Thr Leu Pro 
385                 390                 395                 400 


Ser Met Glu Asp Met Met Asn Asp Ile Asn Glu Lys Met Glu Lys Lys 
                405                 410                 415     


Arg Lys Trp Phe Gly Lys Ser Glu Thr Ile Gln Thr Asp Tyr Ile Val 
            420                 425                 430         


Tyr Met Asp Glu Leu Ser Ser Phe Ile Gly Ala Lys Pro Asn Ile Pro 
        435                 440                 445             


Trp Leu Phe Leu Thr Asp Pro Lys Leu Ala Met Glu Val Tyr Phe Gly 
    450                 455                 460                 


Pro Cys Ser Pro Tyr Gln Phe Arg Leu Val Gly Pro Gly Gln Trp Pro 
465                 470                 475                 480 


Gly Ala Arg Asn Ala Ile Leu Thr Gln Trp Asp Arg Ser Leu Lys Pro 
                485                 490                 495     


Met Gln Thr Arg Val Val Gly Arg Leu Gln Lys Pro Cys Phe Phe Phe 
            500                 505                 510         


His Trp Leu Lys Leu Phe Ala Ile Pro Ile Leu Leu Ile Ala Val Phe 
        515                 520                 525             


Leu Val Leu Thr 
    530         


<210>  4110
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMO4__Homo_sapiens__NP_002013

<400>  4110

Met Ala Lys Lys Val Ala Val Ile Gly Ala Gly Val Ser Gly Leu Ser 
1               5                   10                  15      


Ser Ile Lys Cys Cys Val Asp Glu Asp Leu Glu Pro Thr Cys Phe Glu 
            20                  25                  30          


Arg Ser Asp Asp Ile Gly Gly Leu Trp Lys Phe Thr Glu Ser Ser Lys 
        35                  40                  45              


Asp Gly Met Thr Arg Val Tyr Lys Ser Leu Val Thr Asn Val Cys Lys 
    50                  55                  60                  


Glu Met Ser Cys Tyr Ser Asp Phe Pro Phe His Glu Asp Tyr Pro Asn 
65                  70                  75                  80  


Phe Met Asn His Glu Lys Phe Trp Asp Tyr Leu Gln Glu Phe Ala Glu 
                85                  90                  95      


His Phe Asp Leu Leu Lys Tyr Ile Gln Phe Lys Thr Thr Val Cys Ser 
            100                 105                 110         


Ile Thr Lys Arg Pro Asp Phe Ser Glu Thr Gly Gln Trp Asp Val Val 
        115                 120                 125             


Thr Glu Thr Glu Gly Lys Gln Asn Arg Ala Val Phe Asp Ala Val Met 
    130                 135                 140                 


Val Cys Thr Gly His Phe Leu Asn Pro His Leu Pro Leu Glu Ala Phe 
145                 150                 155                 160 


Pro Gly Ile His Lys Phe Lys Gly Gln Ile Leu His Ser Gln Glu Tyr 
                165                 170                 175     


Lys Ile Pro Glu Gly Phe Gln Gly Lys Arg Val Leu Val Ile Gly Leu 
            180                 185                 190         


Gly Asn Thr Gly Gly Asp Ile Ala Val Glu Leu Ser Arg Thr Ala Ala 
        195                 200                 205             


Gln Val Leu Leu Ser Thr Arg Thr Gly Thr Trp Val Leu Gly Arg Ser 
    210                 215                 220                 


Ser Asp Trp Gly Tyr Pro Tyr Asn Met Met Val Thr Arg Arg Cys Cys 
225                 230                 235                 240 


Ser Phe Ile Ala Gln Val Leu Pro Ser Arg Phe Leu Asn Trp Ile Gln 
                245                 250                 255     


Glu Arg Lys Leu Asn Lys Arg Phe Asn His Glu Asp Tyr Gly Leu Ser 
            260                 265                 270         


Ile Thr Lys Gly Lys Lys Ala Lys Phe Ile Val Asn Asp Glu Leu Pro 
        275                 280                 285             


Asn Cys Ile Leu Cys Gly Ala Ile Thr Met Lys Thr Ser Val Ile Glu 
    290                 295                 300                 


Phe Thr Glu Thr Ser Ala Val Phe Glu Asp Gly Thr Val Glu Glu Asn 
305                 310                 315                 320 


Ile Asp Val Val Ile Phe Thr Thr Gly Tyr Thr Phe Ser Phe Pro Phe 
                325                 330                 335     


Phe Glu Glu Pro Leu Lys Ser Leu Cys Thr Lys Lys Ile Phe Leu Tyr 
            340                 345                 350         


Lys Gln Val Phe Pro Leu Asn Leu Glu Arg Ala Thr Leu Ala Ile Ile 
        355                 360                 365             


Gly Leu Ile Gly Leu Lys Gly Ser Ile Leu Ser Gly Thr Glu Leu Gln 
    370                 375                 380                 


Ala Arg Trp Val Thr Arg Val Phe Lys Gly Leu Cys Lys Ile Pro Pro 
385                 390                 395                 400 


Ser Gln Lys Leu Met Met Glu Ala Thr Glu Lys Glu Gln Leu Ile Lys 
                405                 410                 415     


Arg Gly Val Phe Lys Asp Thr Ser Lys Asp Lys Phe Asp Tyr Ile Ala 
            420                 425                 430         


Tyr Met Asp Asp Ile Ala Ala Cys Ile Gly Thr Lys Pro Ser Ile Pro 
        435                 440                 445             


Leu Leu Phe Leu Lys Asp Pro Arg Leu Ala Trp Glu Val Phe Phe Gly 
    450                 455                 460                 


Pro Cys Thr Pro Tyr Gln Tyr Arg Leu Met Gly Pro Gly Lys Trp Asp 
465                 470                 475                 480 


Gly Ala Arg Asn Ala Ile Leu Thr Gln Trp Asp Arg Thr Leu Lys Pro 
                485                 490                 495     


Leu Lys Thr Arg Ile Val Pro Asp Ser Ser Lys Pro Ala Ser Met Ser 
            500                 505                 510         


His Tyr Leu Lys Ala Trp Gly Ala Pro Val Leu Leu Ala Ser Leu Leu 
        515                 520                 525             


Leu Ile Cys Lys Ser Ser Leu Phe Leu Lys Leu Val Arg Asp Lys Leu 
    530                 535                 540                 


Gln Asp Arg Met Ser Pro Tyr Leu Val Ser Leu Trp Arg Gly 
545                 550                 555             


<210>  4111
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMOD__Homo_sapiens__NP_002014

<400>  4111

Met Gln Trp Thr Ser Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gln Ala Gln Tyr Glu Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg 
            20                  25                  30          


Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu 
        35                  40                  45              


Thr Tyr Glu Pro Tyr Pro Tyr Gly Val Asp Glu Gly Pro Ala Tyr Thr 
    50                  55                  60                  


Tyr Gly Ser Pro Ser Pro Pro Asp Pro Arg Asp Cys Pro Gln Glu Cys 
65                  70                  75                  80  


Asp Cys Pro Pro Asn Phe Pro Thr Ala Met Tyr Cys Asp Asn Arg Asn 
                85                  90                  95      


Leu Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe 
            100                 105                 110         


Gln Asn Asn Gln Ile Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala 
        115                 120                 125             


Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
    130                 135                 140                 


Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
145                 150                 155                 160 


Tyr Leu Asp His Asn Asn Leu Thr Arg Met Pro Gly Pro Leu Pro Arg 
                165                 170                 175     


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            180                 185                 190         


Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln 
        195                 200                 205             


His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg Gly Leu Arg Ser 
    210                 215                 220                 


Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
225                 230                 235                 240 


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val 
                245                 250                 255     


Tyr Thr Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr 
            260                 265                 270         


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
        275                 280                 285             


Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln 
    290                 295                 300                 


Leu Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu 
305                 310                 315                 320 


Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys Thr Val 
                325                 330                 335     


Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
            340                 345                 350         


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
        355                 360                 365             


Arg Leu Ala Ser Leu Ile Glu Ile 
    370                 375     


<210>  4112
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMR1__Homo_sapiens__NP_001172004

<400>  4112

Met Glu Glu Leu Val Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Ala Phe Val Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg 
        35                  40                  45              


Phe Pro Pro Pro Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Glu Lys Glu Pro Cys Cys Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Ile Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Ile Glu Arg Leu 
            100                 105                 110         


Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp Thr Phe His Lys 
        115                 120                 125             


Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met Cys Ala Lys Glu 
    130                 135                 140                 


Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Phe Ser Val Thr 
145                 150                 155                 160 


Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser Ile Asn Glu Val 
                165                 170                 175     


Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His Phe Arg Ser Leu 
            180                 185                 190         


Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu Ala Ser Lys Gln 
        195                 200                 205             


Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His Glu Gln Phe Ile 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ala Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Asp Leu Asp 
                245                 250                 255     


Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp Gln Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp Val Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Leu Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Ala 
305                 310                 315                 320 


Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile Met Pro Pro Asn 
                325                 330                 335     


Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn Ala Pro Glu Glu 
            340                 345                 350         


Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His Phe Ser Gln Pro 
        355                 360                 365             


Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser Ser Val Val Ala 
    370                 375                 380                 


Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln Gly Met Val Pro 
385                 390                 395                 400 


Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu 
                405                 410                 415     


Leu Asp Tyr His Leu Asn Tyr Leu Lys Leu Gln Gln Arg Lys Arg Gly 
            420                 425                 430         


Arg Ala Ser Cys Ala Glu Glu Thr Asp Gly Gly Val Glu Gly Glu Glu 
        435                 440                 445             


Glu Asp Lys Glu Glu Glu Asp Val Glu Glu Ala Ser Lys Glu Thr Thr 
    450                 455                 460                 


Ile Thr Pro Glu Gln Ile Ile Val His Val Ile Gln Glu Arg Leu Lys 
465                 470                 475                 480 


Glu Glu Gln Gln Met Asp Pro Phe Arg Ser Glu Leu Thr Ala Ile Met 
                485                 490                 495     


Lys Gly Val Ser Thr Leu Lys His Tyr Arg Ile Pro Pro Val Lys Val 
            500                 505                 510         


Val Gly Cys Ala Arg Val Lys Ile Val Thr Arg Arg Lys Arg Ser Gln 
        515                 520                 525             


Thr Ala Trp Met Val Ser Asn His Ser 
    530                 535         


<210>  4113
<211>  2355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FN1__Homo_sapiens__NP_002017

<400>  4113

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    2075                 2080                 2085             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2090                 2095                 2100             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2105                 2110                 2115             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2120                 2125                 2130             


Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2135                 2140                 2145             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2150                 2155                 2160             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2165                 2170                 2175             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2180                 2185                 2190             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2195                 2200                 2205             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2210                 2215                 2220             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2225                 2230                 2235             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2240                 2245                 2250             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2255                 2260                 2265             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2270                 2275                 2280             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2285                 2290                 2295             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2300                 2305                 2310             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2315                 2320                 2325             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2330                 2335                 2340             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2345                 2350                 2355 


<210>  4114
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FN3K__Homo_sapiens__NP_071441

<400>  4114

Met Glu Gln Leu Leu Arg Ala Glu Leu Arg Thr Ala Thr Leu Arg Ala 
1               5                   10                  15      


Phe Gly Gly Pro Gly Ala Gly Cys Ile Ser Glu Gly Arg Ala Tyr Asp 
            20                  25                  30          


Thr Asp Ala Gly Pro Val Phe Val Lys Val Asn Arg Arg Thr Gln Ala 
        35                  40                  45              


Arg Gln Met Phe Glu Gly Glu Val Ala Ser Leu Glu Ala Leu Arg Ser 
    50                  55                  60                  


Thr Gly Leu Val Arg Val Pro Arg Pro Met Lys Val Ile Asp Leu Pro 
65                  70                  75                  80  


Gly Gly Gly Ala Ala Phe Val Met Glu His Leu Lys Met Lys Ser Leu 
                85                  90                  95      


Ser Ser Gln Ala Ser Lys Leu Gly Glu Gln Met Ala Asp Leu His Leu 
            100                 105                 110         


Tyr Asn Gln Lys Leu Arg Glu Lys Leu Lys Glu Glu Glu Asn Thr Val 
        115                 120                 125             


Gly Arg Arg Gly Glu Gly Ala Glu Pro Gln Tyr Val Asp Lys Phe Gly 
    130                 135                 140                 


Phe His Thr Val Thr Cys Cys Gly Phe Ile Pro Gln Val Asn Glu Trp 
145                 150                 155                 160 


Gln Asp Asp Trp Pro Thr Phe Phe Ala Arg His Arg Leu Gln Ala Gln 
                165                 170                 175     


Leu Asp Leu Ile Glu Lys Asp Tyr Ala Asp Arg Glu Ala Arg Glu Leu 
            180                 185                 190         


Trp Ser Arg Leu Gln Val Lys Ile Pro Asp Leu Phe Cys Gly Leu Glu 
        195                 200                 205             


Ile Val Pro Ala Leu Leu His Gly Asp Leu Trp Ser Gly Asn Val Ala 
    210                 215                 220                 


Glu Asp Asp Val Gly Pro Ile Ile Tyr Asp Pro Ala Ser Phe Tyr Gly 
225                 230                 235                 240 


His Ser Glu Phe Glu Leu Ala Ile Ala Leu Met Phe Gly Gly Phe Pro 
                245                 250                 255     


Arg Ser Phe Phe Thr Ala Tyr His Arg Lys Ile Pro Lys Ala Pro Gly 
            260                 265                 270         


Phe Asp Gln Arg Leu Leu Leu Tyr Gln Leu Phe Asn Tyr Leu Asn His 
        275                 280                 285             


Trp Asn His Phe Gly Arg Glu Tyr Arg Ser Pro Ser Leu Gly Thr Met 
    290                 295                 300                 


Arg Arg Leu Leu Lys 
305                 


<210>  4115
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FN3KRP__Homo_sapiens__NP_078895

<400>  4115

Met Glu Glu Leu Leu Arg Arg Glu Leu Gly Cys Ser Ser Val Arg Ala 
1               5                   10                  15      


Thr Gly His Ser Gly Gly Gly Cys Ile Ser Gln Gly Arg Ser Tyr Asp 
            20                  25                  30          


Thr Asp Gln Gly Arg Val Phe Val Lys Val Asn Pro Lys Ala Glu Ala 
        35                  40                  45              


Arg Arg Met Phe Glu Gly Glu Met Ala Ser Leu Thr Ala Ile Leu Lys 
    50                  55                  60                  


Thr Asn Thr Val Lys Val Pro Lys Pro Ile Lys Val Leu Asp Ala Pro 
65                  70                  75                  80  


Gly Gly Gly Ser Val Leu Val Met Glu His Met Asp Met Arg His Leu 
                85                  90                  95      


Ser Ser His Ala Ala Lys Leu Gly Ala Gln Leu Ala Asp Leu His Leu 
            100                 105                 110         


Asp Asn Lys Lys Leu Gly Glu Met Arg Leu Lys Glu Ala Gly Thr Val 
        115                 120                 125             


Gly Arg Gly Gly Gly Gln Glu Glu Arg Pro Phe Val Ala Arg Phe Gly 
    130                 135                 140                 


Phe Asp Val Val Thr Cys Cys Gly Tyr Leu Pro Gln Val Asn Asp Trp 
145                 150                 155                 160 


Gln Glu Asp Trp Val Val Phe Tyr Ala Arg Gln Arg Ile Gln Pro Gln 
                165                 170                 175     


Met Asp Met Val Glu Lys Glu Ser Gly Asp Arg Glu Ala Leu Gln Leu 
            180                 185                 190         


Trp Ser Ala Leu Gln Leu Lys Ile Pro Asp Leu Phe Arg Asp Leu Glu 
        195                 200                 205             


Ile Ile Pro Ala Leu Leu His Gly Asp Leu Trp Gly Gly Asn Val Ala 
    210                 215                 220                 


Glu Asp Ser Ser Gly Pro Val Ile Phe Asp Pro Ala Ser Phe Tyr Gly 
225                 230                 235                 240 


His Ser Glu Tyr Glu Leu Ala Ile Ala Gly Met Phe Gly Gly Phe Ser 
                245                 250                 255     


Ser Ser Phe Tyr Ser Ala Tyr His Gly Lys Ile Pro Lys Ala Pro Gly 
            260                 265                 270         


Phe Glu Lys Arg Leu Gln Leu Tyr Gln Leu Phe His Tyr Leu Asn His 
        275                 280                 285             


Trp Asn His Phe Gly Ser Gly Tyr Arg Gly Ser Ser Leu Asn Ile Met 
    290                 295                 300                 


Arg Asn Leu Val Lys 
305                 


<210>  4116
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNBP1__Homo_sapiens__NP_055848

<400>  4116

Met Ser Trp Gly Thr Glu Leu Trp Asp Gln Phe Asp Asn Leu Glu Lys 
1               5                   10                  15      


His Thr Gln Trp Gly Ile Asp Ile Leu Glu Lys Tyr Ile Lys Phe Val 
            20                  25                  30          


Lys Glu Arg Thr Glu Ile Glu Leu Ser Tyr Ala Lys Gln Leu Arg Asn 
        35                  40                  45              


Leu Ser Lys Lys Tyr Gln Pro Lys Lys Asn Ser Lys Glu Glu Glu Glu 
    50                  55                  60                  


Tyr Lys Tyr Thr Ser Cys Lys Ala Phe Ile Ser Asn Leu Asn Glu Met 
65                  70                  75                  80  


Asn Asp Tyr Ala Gly Gln His Glu Val Ile Ser Glu Asn Met Ala Ser 
                85                  90                  95      


Gln Ile Ile Val Asp Leu Ala Arg Tyr Val Gln Glu Leu Lys Gln Glu 
            100                 105                 110         


Arg Lys Ser Asn Phe His Asp Gly Arg Lys Ala Gln Gln His Ile Glu 
        115                 120                 125             


Thr Cys Trp Lys Gln Leu Glu Ser Ser Lys Arg Arg Phe Glu Arg Asp 
    130                 135                 140                 


Cys Lys Glu Ala Asp Arg Ala Gln Gln Tyr Phe Glu Lys Met Asp Ala 
145                 150                 155                 160 


Asp Ile Asn Val Thr Lys Ala Asp Val Glu Lys Ala Arg Gln Gln Ala 
                165                 170                 175     


Gln Ile Arg His Gln Met Ala Glu Asp Ser Lys Ala Asp Tyr Ser Ser 
            180                 185                 190         


Ile Leu Gln Lys Phe Asn His Glu Gln His Glu Tyr Tyr His Thr His 
        195                 200                 205             


Ile Pro Asn Ile Phe Gln Lys Ile Gln Glu Met Glu Glu Arg Arg Ile 
    210                 215                 220                 


Val Arg Met Gly Glu Ser Met Lys Thr Tyr Ala Glu Val Asp Arg Gln 
225                 230                 235                 240 


Val Ile Pro Ile Ile Gly Lys Cys Leu Asp Gly Ile Val Lys Ala Ala 
                245                 250                 255     


Glu Ser Ile Asp Gln Lys Asn Asp Ser Gln Leu Val Ile Glu Ala Tyr 
            260                 265                 270         


Lys Ser Gly Phe Glu Pro Pro Gly Asp Ile Glu Phe Glu Asp Tyr Thr 
        275                 280                 285             


Gln Pro Met Lys Arg Thr Val Ser Asp Asn Ser Leu Ser Asn Ser Arg 
    290                 295                 300                 


Gly Glu Gly Lys Pro Asp Leu Lys Phe Gly Gly Lys Ser Lys Gly Lys 
305                 310                 315                 320 


Leu Trp Pro Phe Ile Lys Lys Asn Lys Leu Met Ser Leu Leu Thr Ser 
                325                 330                 335     


Pro His Gln Pro Pro Pro Pro Pro Pro Ala Ser Ala Ser Pro Ser Ala 
            340                 345                 350         


Val Pro Asn Gly Pro Gln Ser Pro Lys Gln Gln Lys Glu Pro Leu Ser 
        355                 360                 365             


His Arg Phe Asn Glu Phe Met Thr Ser Lys Pro Lys Ile His Cys Phe 
    370                 375                 380                 


Arg Ser Leu Lys Arg Gly Leu Ser Leu Lys Leu Gly Ala Thr Pro Glu 
385                 390                 395                 400 


Asp Phe Ser Asn Leu Pro Pro Glu Gln Arg Arg Lys Lys Leu Gln Gln 
                405                 410                 415     


Lys Val Asp Glu Leu Asn Lys Glu Ile Gln Lys Glu Met Asp Gln Arg 
            420                 425                 430         


Asp Ala Ile Thr Lys Met Lys Asp Val Tyr Leu Lys Asn Pro Gln Met 
        435                 440                 445             


Gly Asp Pro Ala Ser Leu Asp His Lys Leu Ala Glu Val Ser Gln Asn 
    450                 455                 460                 


Ile Glu Lys Leu Arg Val Glu Thr Gln Lys Phe Glu Ala Trp Leu Ala 
465                 470                 475                 480 


Glu Val Glu Gly Arg Leu Pro Ala Arg Ser Glu Gln Ala Arg Arg Gln 
                485                 490                 495     


Ser Gly Leu Tyr Asp Ser Gln Asn Pro Pro Thr Val Asn Asn Cys Ala 
            500                 505                 510         


Gln Asp Arg Glu Ser Pro Asp Gly Ser Tyr Thr Glu Glu Gln Ser Gln 
        515                 520                 525             


Glu Ser Glu Met Lys Val Leu Ala Thr Asp Phe Asp Asp Glu Phe Asp 
    530                 535                 540                 


Asp Glu Glu Pro Leu Pro Ala Ile Gly Thr Cys Lys Ala Leu Tyr Thr 
545                 550                 555                 560 


Phe Glu Gly Gln Asn Glu Gly Thr Ile Ser Val Val Glu Gly Glu Thr 
                565                 570                 575     


Leu Tyr Val Ile Glu Glu Asp Lys Gly Asp Gly Trp Thr Arg Ile Arg 
            580                 585                 590         


Arg Asn Glu Asp Glu Glu Gly Tyr Val Pro Thr Ser Tyr Val Glu Val 
        595                 600                 605             


Cys Leu Asp Lys Asn Ala Lys Asp Ser 
    610                 615         


<210>  4117
<211>  1894
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC1__Homo_sapiens__NP_115921

<400>  4117

Met Ala Pro Glu Ala Gly Ala Thr Leu Arg Ala Pro Arg Arg Leu Ser 
1               5                   10                  15      


Trp Ala Ala Leu Leu Leu Leu Ala Ala Leu Leu Pro Val Ala Ser Ser 
            20                  25                  30          


Ala Ala Ala Ser Val Asp His Pro Leu Lys Pro Arg His Val Lys Leu 
        35                  40                  45              


Leu Ser Thr Lys Met Gly Leu Lys Val Thr Trp Asp Pro Pro Lys Asp 
    50                  55                  60                  


Ala Thr Ser Arg Pro Val Glu His Tyr Asn Ile Ala Tyr Gly Lys Ser 
65                  70                  75                  80  


Leu Lys Ser Leu Lys Tyr Ile Lys Val Asn Ala Glu Thr Tyr Ser Phe 
                85                  90                  95      


Leu Ile Glu Asp Val Glu Pro Gly Val Val Tyr Phe Val Leu Leu Thr 
            100                 105                 110         


Ala Glu Asn His Ser Gly Val Ser Arg Pro Val Tyr Arg Ala Glu Ser 
        115                 120                 125             


Pro Pro Gly Gly Glu Trp Ile Glu Ile Asp Gly Phe Pro Ile Lys Gly 
    130                 135                 140                 


Pro Gly Pro Phe Asn Glu Thr Val Thr Glu Lys Glu Val Pro Asn Lys 
145                 150                 155                 160 


Pro Leu Arg Val Arg Val Arg Ser Ser Asp Asp Arg Leu Ser Val Ala 
                165                 170                 175     


Trp Lys Ala Pro Arg Leu Ser Gly Ala Lys Ser Pro Arg Arg Ser Arg 
            180                 185                 190         


Gly Phe Leu Leu Gly Tyr Gly Glu Ser Gly Arg Lys Met Asn Tyr Val 
        195                 200                 205             


Pro Leu Thr Arg Asp Glu Arg Thr His Glu Ile Lys Lys Leu Ala Ser 
    210                 215                 220                 


Glu Ser Val Tyr Val Val Ser Leu Gln Ser Met Asn Ser Gln Gly Arg 
225                 230                 235                 240 


Ser Gln Pro Val Tyr Arg Ala Ala Leu Thr Lys Arg Lys Ile Ser Glu 
                245                 250                 255     


Glu Asp Glu Leu Asp Val Pro Asp Asp Ile Ser Val Arg Val Met Ser 
            260                 265                 270         


Ser Gln Ser Val Leu Val Ser Trp Val Asp Pro Val Leu Glu Lys Gln 
        275                 280                 285             


Lys Lys Val Val Ala Ser Arg Gln Tyr Thr Val Arg Tyr Arg Glu Lys 
    290                 295                 300                 


Gly Glu Leu Ala Arg Trp Asp Tyr Lys Gln Ile Ala Asn Arg Arg Val 
305                 310                 315                 320 


Leu Ile Glu Asn Leu Ile Pro Asp Thr Val Tyr Glu Phe Ala Val Arg 
                325                 330                 335     


Ile Ser Gln Gly Glu Arg Asp Gly Lys Trp Ser Thr Ser Val Phe Gln 
            340                 345                 350         


Arg Thr Pro Glu Ser Ala Pro Thr Thr Ala Pro Glu Asn Leu Asn Val 
        355                 360                 365             


Trp Pro Val Asn Gly Lys Pro Thr Val Val Ala Ala Ser Trp Asp Ala 
    370                 375                 380                 


Leu Pro Glu Thr Glu Gly Lys Val Lys Glu Tyr Ile Leu Ser Tyr Ala 
385                 390                 395                 400 


Pro Ala Leu Lys Pro Phe Gly Ala Lys Ser Leu Thr Tyr Pro Gly Asp 
                405                 410                 415     


Thr Thr Ser Ala Leu Val Asp Gly Leu Gln Pro Gly Glu Arg Tyr Leu 
            420                 425                 430         


Phe Lys Ile Arg Ala Thr Asn Arg Arg Gly Leu Gly Pro His Ser Lys 
        435                 440                 445             


Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp Val Glu Gln 
    450                 455                 460                 


Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro Ser Ser Pro 
465                 470                 475                 480 


Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val Pro Ala Ser 
                485                 490                 495     


Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu Lys Asn Lys 
            500                 505                 510         


Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu Arg Ala Lys 
        515                 520                 525             


Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr Gly Glu Glu 
    530                 535                 540                 


Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser Asp Thr Gln 
545                 550                 555                 560 


Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly His Ser Val 
                565                 570                 575     


Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro Ala Leu Pro 
            580                 585                 590         


Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala Thr Gln Pro 
        595                 600                 605             


Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala His His Ala 
    610                 615                 620                 


Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala Ser Leu Asn 
625                 630                 635                 640 


Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala Val Gly Ser 
                645                 650                 655     


Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala Leu Ser Pro 
            660                 665                 670         


Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser Ser Val His 
        675                 680                 685             


Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro His Ser Gly 
    690                 695                 700                 


Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser Arg Leu Ser 
705                 710                 715                 720 


Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln Pro His Leu 
                725                 730                 735     


Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp Ala Pro Ala 
            740                 745                 750         


Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser Ser Val Ser 
        755                 760                 765             


Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala Glu Ala Ser 
    770                 775                 780                 


Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly Gly Arg Gln 
785                 790                 795                 800 


Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala Ser Gly His 
                805                 810                 815     


Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly Arg Ser Pro 
            820                 825                 830         


Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro Ser Ser Ser 
        835                 840                 845             


Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val Pro Ser His 
    850                 855                 860                 


Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly Asp Glu Glu 
865                 870                 875                 880 


Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His Val Pro Ser 
                885                 890                 895     


Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu Arg Arg Ser 
            900                 905                 910         


Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile Pro Glu Asn 
        915                 920                 925             


Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys Tyr Ser Ser 
    930                 935                 940                 


Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp Ala Asp Thr 
945                 950                 955                 960 


Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp Arg His Ala 
                965                 970                 975     


Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His Pro Ser Val 
            980                 985                 990         


Pro Arg Arg Met Thr Pro Gly Arg  Ala Pro Gln Gln Gln  Pro Pro Pro 
        995                 1000                 1005             


Pro Val  Ala Thr Ser Gln His  His Pro Gly Pro Gln  Ser Arg Asp 
    1010                 1015                 1020             


Ala Gly  Arg Ser Pro Ser Gln  Pro Arg Leu Ser Leu  Thr Gln Ala 
    1025                 1030                 1035             


Gly Arg  Pro Arg Pro Thr Ser  Gln Gly Arg Ser His  Ser Ser Ser 
    1040                 1045                 1050             


Asp Pro  Tyr Thr Ala Ser Ser  Arg Gly Met Leu Pro  Thr Ala Leu 
    1055                 1060                 1065             


Gln Asn  Gln Asp Glu Asp Ala  Gln Gly Ser Tyr Asp  Asp Asp Ser 
    1070                 1075                 1080             


Thr Glu  Val Glu Ala Gln Asp  Val Arg Ala Pro Ala  His Ala Ala 
    1085                 1090                 1095             


Arg Ala  Lys Glu Ala Ala Ala  Ser Leu Pro Lys His  Gln Gln Val 
    1100                 1105                 1110             


Glu Ser  Pro Thr Gly Ala Gly  Ala Gly Gly Asp His  Arg Ser Gln 
    1115                 1120                 1125             


Arg Gly  His Ala Ala Ser Pro  Ala Arg Pro Ser Arg  Pro Gly Gly 
    1130                 1135                 1140             


Pro Gln  Ser Arg Ala Arg Val  Pro Ser Arg Ala Ala  Pro Gly Lys 
    1145                 1150                 1155             


Ser Glu  Pro Pro Ser Lys Arg  Pro Leu Ser Ser Lys  Ser Gln Gln 
    1160                 1165                 1170             


Ser Val  Ser Ala Glu Asp Asp  Glu Glu Glu Asp Ala  Gly Phe Phe 
    1175                 1180                 1185             


Lys Gly  Gly Lys Glu Asp Leu  Leu Ser Ser Ser Val  Pro Lys Trp 
    1190                 1195                 1200             


Pro Ser  Ser Ser Thr Pro Arg  Gly Gly Lys Asp Ala  Asp Gly Ser 
    1205                 1210                 1215             


Leu Ala  Lys Glu Glu Arg Glu  Pro Ala Ile Ala Leu  Ala Pro Arg 
    1220                 1225                 1230             


Gly Gly  Ser Leu Ala Pro Val  Lys Arg Pro Leu Pro  Pro Pro Pro 
    1235                 1240                 1245             


Gly Ser  Ser Pro Arg Ala Ser  His Val Pro Ser Arg  Leu Pro Pro 
    1250                 1255                 1260             


Arg Ser  Ala Ala Thr Val Ser  Pro Val Ala Gly Thr  His Pro Trp 
    1265                 1270                 1275             


Pro Gln  Tyr Thr Thr Arg Ala  Pro Pro Gly His Phe  Ser Thr Thr 
    1280                 1285                 1290             


Pro Met  Leu Ser Leu Arg Gln  Arg Met Met His Ala  Arg Phe Arg 
    1295                 1300                 1305             


Asn Pro  Leu Ser Arg Gln Pro  Ala Arg Pro Ser Tyr  Arg Gln Gly 
    1310                 1315                 1320             


Tyr Asn  Gly Arg Pro Asn Val  Glu Gly Lys Val Leu  Pro Gly Ser 
    1325                 1330                 1335             


Asn Gly  Lys Pro Asn Gly Gln  Arg Ile Ile Asn Gly  Pro Gln Gly 
    1340                 1345                 1350             


Thr Lys  Trp Val Val Asp Leu  Asp Arg Gly Leu Val  Leu Asn Ala 
    1355                 1360                 1365             


Glu Gly  Arg Tyr Leu Gln Asp  Ser His Gly Asn Pro  Leu Arg Ile 
    1370                 1375                 1380             


Lys Leu  Gly Gly Asp Gly Arg  Thr Ile Val Asp Leu  Glu Gly Thr 
    1385                 1390                 1395             


Pro Val  Val Ser Pro Asp Gly  Leu Pro Leu Phe Gly  Gln Gly Arg 
    1400                 1405                 1410             


His Gly  Thr Pro Leu Ala Asn  Ala Gln Asp Lys Pro  Ile Leu Ser 
    1415                 1420                 1425             


Leu Gly  Gly Lys Pro Leu Val  Gly Leu Glu Val Ile  Lys Lys Thr 
    1430                 1435                 1440             


Thr His  Pro Pro Thr Thr Thr  Met Gln Pro Thr Thr  Thr Thr Thr 
    1445                 1450                 1455             


Pro Leu  Pro Thr Thr Thr Thr  Pro Arg Pro Thr Thr  Ala Thr Thr 
    1460                 1465                 1470             


Arg Arg  Thr Thr Thr Thr Arg  Arg Thr Thr Thr Arg  Arg Pro Thr 
    1475                 1480                 1485             


Thr Thr  Val Arg Thr Thr Thr  Arg Thr Thr Thr Thr  Thr Thr Pro 
    1490                 1495                 1500             


Thr Pro  Thr Thr Pro Ile Pro  Thr Cys Pro Pro Gly  Thr Leu Glu 
    1505                 1510                 1515             


Arg His  Asp Asp Asp Gly Asn  Leu Ile Met Ser Ser  Asn Gly Ile 
    1520                 1525                 1530             


Pro Glu  Cys Tyr Ala Glu Glu  Asp Glu Phe Ser Gly  Leu Glu Thr 
    1535                 1540                 1545             


Asp Thr  Ala Val Pro Thr Glu  Glu Ala Tyr Val Ile  Tyr Asp Glu 
    1550                 1555                 1560             


Asp Tyr  Glu Phe Glu Thr Ser  Arg Pro Pro Thr Thr  Thr Glu Pro 
    1565                 1570                 1575             


Ser Thr  Thr Ala Thr Thr Pro  Arg Val Ile Pro Glu  Glu Gly Ala 
    1580                 1585                 1590             


Ile Ser  Ser Phe Pro Glu Glu  Glu Phe Asp Leu Ala  Gly Arg Lys 
    1595                 1600                 1605             


Arg Phe  Val Ala Pro Tyr Val  Thr Tyr Leu Asn Lys  Asp Pro Ser 
    1610                 1615                 1620             


Ala Pro  Cys Ser Leu Thr Asp  Ala Leu Asp His Phe  Gln Val Asp 
    1625                 1630                 1635             


Ser Leu  Asp Glu Ile Ile Pro  Asn Asp Leu Lys Lys  Ser Asp Leu 
    1640                 1645                 1650             


Pro Pro  Gln His Ala Pro Arg  Asn Ile Thr Val Val  Ala Val Glu 
    1655                 1660                 1665             


Gly Cys  His Ser Phe Val Ile  Val Asp Trp Asp Lys  Ala Thr Pro 
    1670                 1675                 1680             


Gly Asp  Val Val Thr Gly Tyr  Leu Val Tyr Ser Ala  Ser Tyr Glu 
    1685                 1690                 1695             


Asp Phe  Ile Arg Asn Lys Trp  Ser Thr Gln Ala Ser  Ser Val Thr 
    1700                 1705                 1710             


His Leu  Pro Ile Glu Asn Leu  Lys Pro Asn Thr Arg  Tyr Tyr Phe 
    1715                 1720                 1725             


Lys Val  Gln Ala Gln Asn Pro  His Gly Tyr Gly Pro  Ile Ser Pro 
    1730                 1735                 1740             


Ser Val  Ser Phe Val Thr Glu  Ser Asp Asn Pro Leu  Leu Val Val 
    1745                 1750                 1755             


Arg Pro  Pro Gly Gly Glu Pro  Ile Trp Ile Pro Phe  Ala Phe Lys 
    1760                 1765                 1770             


His Asp  Pro Ser Tyr Thr Asp  Cys His Gly Arg Gln  Tyr Val Lys 
    1775                 1780                 1785             


Arg Thr  Trp Tyr Arg Lys Phe  Val Gly Val Val Leu  Cys Asn Ser 
    1790                 1795                 1800             


Leu Arg  Tyr Lys Ile Tyr Leu  Ser Asp Asn Leu Lys  Asp Thr Phe 
    1805                 1810                 1815             


Tyr Ser  Ile Gly Asp Ser Trp  Gly Arg Gly Glu Asp  His Cys Gln 
    1820                 1825                 1830             


Phe Val  Asp Ser His Leu Asp  Gly Arg Thr Gly Pro  Gln Ser Tyr 
    1835                 1840                 1845             


Val Glu  Ala Leu Pro Thr Ile  Gln Gly Tyr Tyr Arg  Gln Tyr Arg 
    1850                 1855                 1860             


Gln Glu  Pro Val Arg Phe Gly  Asn Ile Gly Phe Gly  Thr Pro Tyr 
    1865                 1870                 1875             


Tyr Tyr  Val Gly Trp Tyr Glu  Cys Gly Val Ser Ile  Pro Gly Lys 
    1880                 1885                 1890             


Trp 
    


<210>  4118
<211>  1198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC3A__Homo_sapiens__NP_001073141

<400>  4118

Met Ala Glu His Pro Pro Leu Leu Asp Thr Thr Gln Ile Leu Ser Ser 
1               5                   10                  15      


Asp Ile Ser Leu Leu Ser Ala Pro Ile Val Ser Ala Asp Gly Thr Gln 
            20                  25                  30          


Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Ala Phe Thr Ile Arg 
        35                  40                  45              


Arg Glu Asp Gly Gln Phe Gln Cys Ile Thr Gly Pro Ala Gln Val Pro 
    50                  55                  60                  


Met Met Ser Pro Asn Gly Ser Val Pro Pro Ile Tyr Val Pro Pro Gly 
65                  70                  75                  80  


Tyr Ala Pro Gln Val Ile Glu Asp Asn Gly Val Arg Arg Val Val Val 
                85                  90                  95      


Val Pro Gln Ala Pro Glu Phe His Pro Gly Ser His Thr Val Leu His 
            100                 105                 110         


Arg Ser Pro His Pro Pro Leu Pro Gly Phe Ile Pro Val Pro Thr Met 
        115                 120                 125             


Met Pro Pro Pro Pro Arg His Met Tyr Ser Pro Val Thr Gly Ala Gly 
    130                 135                 140                 


Asp Met Thr Thr Gln Tyr Met Pro Gln Tyr Gln Ser Ser Gln Val Tyr 
145                 150                 155                 160 


Gly Asp Val Asp Ala His Ser Thr His Gly Arg Ser Asn Phe Arg Asp 
                165                 170                 175     


Glu Arg Ser Ser Lys Thr Tyr Glu Arg Leu Gln Lys Lys Leu Lys Asp 
            180                 185                 190         


Arg Gln Gly Thr Gln Lys Asp Lys Met Ser Ser Pro Pro Ser Ser Pro 
        195                 200                 205             


Gln Lys Cys Pro Ser Pro Ile Asn Glu His Asn Gly Leu Ile Lys Gly 
    210                 215                 220                 


Gln Ile Ala Gly Gly Ile Asn Thr Gly Ser Ala Lys Ile Lys Ser Gly 
225                 230                 235                 240 


Lys Gly Lys Gly Gly Thr Gln Val Asp Thr Glu Ile Glu Glu Lys Asp 
                245                 250                 255     


Glu Glu Thr Lys Ala Phe Glu Ala Leu Leu Ser Asn Ile Val Lys Pro 
            260                 265                 270         


Val Ala Ser Asp Ile Gln Ala Arg Thr Val Val Leu Thr Trp Ser Pro 
        275                 280                 285             


Pro Ser Ser Leu Ile Asn Gly Glu Thr Asp Glu Ser Ser Val Pro Glu 
    290                 295                 300                 


Leu Tyr Gly Tyr Glu Val Leu Ile Ser Ser Thr Gly Lys Asp Gly Lys 
305                 310                 315                 320 


Tyr Lys Ser Val Tyr Val Gly Glu Glu Thr Asn Ile Thr Leu Asn Asp 
                325                 330                 335     


Leu Lys Pro Ala Met Asp Tyr His Ala Lys Val Gln Ala Glu Tyr Asn 
            340                 345                 350         


Ser Ile Lys Gly Thr Pro Ser Glu Ala Glu Ile Phe Thr Thr Leu Ser 
        355                 360                 365             


Cys Glu Pro Asp Ile Pro Asn Pro Pro Arg Ile Ala Asn Arg Thr Lys 
    370                 375                 380                 


Asn Ser Leu Thr Leu Gln Trp Lys Ala Pro Ser Asp Asn Gly Ser Lys 
385                 390                 395                 400 


Ile Gln Asn Phe Val Leu Glu Trp Asp Glu Gly Lys Gly Asn Gly Glu 
                405                 410                 415     


Phe Cys Gln Cys Tyr Met Gly Ser Gln Lys Gln Phe Lys Ile Thr Lys 
            420                 425                 430         


Leu Ser Pro Ala Met Gly Cys Lys Phe Arg Leu Ser Ala Arg Asn Asp 
        435                 440                 445             


Tyr Gly Thr Ser Gly Phe Ser Glu Glu Val Leu Tyr Tyr Thr Ser Gly 
    450                 455                 460                 


Cys Ala Pro Ser Met Pro Ala Ser Pro Val Leu Thr Lys Ala Gly Ile 
465                 470                 475                 480 


Thr Trp Leu Ser Leu Gln Trp Ser Lys Pro Ser Gly Thr Pro Ser Asp 
                485                 490                 495     


Glu Gly Ile Ser Tyr Ile Leu Glu Met Glu Glu Glu Thr Ser Gly Tyr 
            500                 505                 510         


Gly Phe Lys Pro Lys Tyr Asp Gly Glu Asp Leu Ala Tyr Thr Val Lys 
        515                 520                 525             


Asn Leu Arg Arg Ser Thr Lys Tyr Lys Phe Lys Val Ile Ala Tyr Asn 
    530                 535                 540                 


Ser Glu Gly Lys Ser Asn Pro Ser Glu Val Val Glu Phe Thr Thr Cys 
545                 550                 555                 560 


Pro Asp Lys Pro Gly Ile Pro Val Lys Pro Ser Val Lys Gly Lys Ile 
                565                 570                 575     


His Ser His Ser Phe Lys Ile Thr Trp Asp Pro Pro Lys Asp Asn Gly 
            580                 585                 590         


Gly Ala Thr Ile Asn Lys Tyr Val Val Glu Met Ala Glu Gly Ser Asn 
        595                 600                 605             


Gly Asn Lys Trp Glu Met Ile Tyr Ser Gly Ala Thr Arg Glu His Leu 
    610                 615                 620                 


Cys Asp Arg Leu Asn Pro Gly Cys Phe Tyr Arg Leu Arg Val Tyr Cys 
625                 630                 635                 640 


Ile Ser Asp Gly Gly Gln Ser Ala Val Ser Glu Ser Leu Leu Val Gln 
                645                 650                 655     


Thr Pro Ala Val Pro Pro Gly Pro Cys Leu Pro Pro Arg Leu Gln Gly 
            660                 665                 670         


Arg Pro Lys Ala Lys Glu Ile Gln Leu Arg Trp Gly Pro Pro Leu Val 
        675                 680                 685             


Asp Gly Gly Ser Pro Ile Ser Cys Tyr Ser Val Glu Met Ser Pro Ile 
    690                 695                 700                 


Glu Lys Asp Glu Pro Arg Glu Val Tyr Gln Gly Ser Glu Val Glu Cys 
705                 710                 715                 720 


Thr Val Ser Ser Leu Leu Pro Gly Lys Thr Tyr Ser Phe Arg Leu Arg 
                725                 730                 735     


Ala Ala Asn Lys Met Gly Phe Gly Pro Phe Ser Glu Lys Cys Asp Ile 
            740                 745                 750         


Thr Thr Ala Pro Gly Pro Pro Asp Gln Cys Lys Pro Pro Gln Val Thr 
        755                 760                 765             


Cys Arg Ser Ala Thr Cys Ala Gln Val Asn Trp Glu Val Pro Leu Ser 
    770                 775                 780                 


Asn Gly Thr Asp Val Thr Glu Tyr Arg Leu Glu Trp Gly Gly Val Glu 
785                 790                 795                 800 


Gly Ser Met Gln Ile Cys Tyr Cys Gly Pro Gly Leu Ser Tyr Glu Ile 
                805                 810                 815     


Lys Gly Leu Ser Pro Ala Thr Thr Tyr Tyr Cys Arg Val Gln Ala Leu 
            820                 825                 830         


Ser Val Val Gly Ala Gly Pro Phe Ser Glu Val Val Ala Cys Val Thr 
        835                 840                 845             


Pro Pro Ser Val Pro Gly Ile Val Thr Cys Leu Gln Glu Ile Ser Asp 
    850                 855                 860                 


Asp Glu Ile Glu Asn Pro His Tyr Ser Pro Ser Thr Cys Leu Ala Ile 
865                 870                 875                 880 


Ser Trp Glu Lys Pro Cys Asp His Gly Ser Glu Ile Leu Ala Tyr Ser 
                885                 890                 895     


Ile Asp Phe Gly Asp Lys Gln Ser Leu Thr Val Gly Lys Val Thr Ser 
            900                 905                 910         


Tyr Ile Ile Asn Asn Leu Gln Pro Asp Thr Thr Tyr Arg Ile Arg Ile 
        915                 920                 925             


Gln Ala Leu Asn Ser Leu Gly Ala Gly Pro Phe Ser His Met Ile Lys 
    930                 935                 940                 


Leu Lys Thr Lys Pro Leu Pro Pro Asp Pro Pro Arg Leu Glu Cys Val 
945                 950                 955                 960 


Ala Phe Ser His Gln Asn Leu Lys Leu Lys Trp Gly Glu Gly Thr Pro 
                965                 970                 975     


Lys Thr Leu Ser Thr Asp Ser Ile Gln Tyr His Leu Gln Met Glu Asp 
            980                 985                 990         


Lys Asn Gly Arg Phe Val Ser Leu  Tyr Arg Gly Pro Cys  His Thr Tyr 
        995                 1000                 1005             


Lys Val  Gln Arg Leu Asn Glu  Ser Thr Ser Tyr Lys  Phe Cys Ile 
    1010                 1015                 1020             


Gln Ala  Cys Asn Glu Ala Gly  Glu Gly Pro Leu Ser  Gln Glu Tyr 
    1025                 1030                 1035             


Ile Phe  Thr Thr Pro Lys Ser  Val Pro Ala Ala Leu  Lys Ala Pro 
    1040                 1045                 1050             


Lys Ile  Glu Lys Val Asn Asp  His Ile Cys Glu Ile  Thr Trp Glu 
    1055                 1060                 1065             


Cys Leu  Gln Pro Met Lys Gly  Asp Pro Val Ile Tyr  Ser Leu Gln 
    1070                 1075                 1080             


Val Met  Leu Gly Lys Asp Ser  Glu Phe Lys Gln Ile  Tyr Lys Gly 
    1085                 1090                 1095             


Pro Asp  Ser Ser Phe Arg Tyr  Ser Ser Leu Gln Leu  Asn Cys Glu 
    1100                 1105                 1110             


Tyr Arg  Phe Arg Val Cys Ala  Ile Arg Gln Cys Gln  Asp Ser Leu 
    1115                 1120                 1125             


Gly His  Gln Asp Leu Val Gly  Pro Tyr Ser Thr Thr  Val Leu Phe 
    1130                 1135                 1140             


Ile Ser  Gln Arg Thr Glu Pro  Pro Ala Ser Thr Asn  Arg Asp Thr 
    1145                 1150                 1155             


Val Glu  Ser Thr Arg Thr Arg  Arg Ala Leu Ser Asp  Glu Gln Cys 
    1160                 1165                 1170             


Ala Ala  Val Ile Leu Val Leu  Phe Ala Phe Phe Ser  Ile Leu Ile 
    1175                 1180                 1185             


Ala Phe  Ile Ile Gln Tyr Phe  Val Ile Lys 
    1190                 1195             


<210>  4119
<211>  1204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC3B__Homo_sapiens__NP_001128567

<400>  4119

Met Tyr Val Thr Met Met Met Thr Asp Gln Ile Pro Leu Glu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Asn Gly Glu Val Ala Met Met Pro His Leu Val Asn Gly 
            20                  25                  30          


Asp Ala Ala Gln Gln Val Ile Leu Val Gln Val Asn Pro Gly Glu Thr 
        35                  40                  45              


Phe Thr Ile Arg Ala Glu Asp Gly Thr Leu Gln Cys Ile Gln Gly Pro 
    50                  55                  60                  


Ala Glu Val Pro Met Met Ser Pro Asn Gly Ser Ile Pro Pro Ile His 
65                  70                  75                  80  


Val Pro Pro Gly Tyr Ile Ser Gln Val Ile Glu Asp Ser Thr Gly Val 
                85                  90                  95      


Arg Arg Val Val Val Thr Pro Gln Ser Pro Glu Cys Tyr Pro Pro Ser 
            100                 105                 110         


Tyr Pro Ser Ala Met Ser Pro Thr His His Leu Pro Pro Tyr Leu Thr 
        115                 120                 125             


His His Pro His Phe Ile His Asn Ser His Thr Ala Tyr Tyr Pro Pro 
    130                 135                 140                 


Val Thr Gly Pro Gly Asp Met Pro Pro Gln Phe Phe Pro Gln His His 
145                 150                 155                 160 


Leu Pro His Thr Ile Tyr Gly Glu Gln Glu Ile Ile Pro Phe Tyr Gly 
                165                 170                 175     


Met Ser Thr Tyr Ile Thr Arg Glu Asp Gln Tyr Ser Lys Pro Pro His 
            180                 185                 190         


Lys Lys Leu Lys Asp Arg Gln Ile Asp Arg Gln Asn Arg Leu Asn Ser 
        195                 200                 205             


Pro Pro Ser Ser Ile Tyr Lys Ser Ser Cys Thr Thr Val Tyr Asn Gly 
    210                 215                 220                 


Tyr Gly Lys Gly His Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Pro Gly Ile Lys Lys Thr Glu Arg Arg Ala Arg Ser Ser Pro Lys 
                245                 250                 255     


Ser Asn Asp Ser Asp Leu Gln Glu Tyr Glu Leu Glu Val Lys Arg Val 
            260                 265                 270         


Gln Asp Ile Leu Ser Gly Ile Glu Lys Pro Gln Val Ser Asn Ile Gln 
        275                 280                 285             


Ala Arg Ala Val Val Leu Ser Trp Ala Pro Pro Val Gly Leu Ser Cys 
    290                 295                 300                 


Gly Pro His Ser Gly Leu Ser Phe Pro Tyr Ser Tyr Glu Val Ala Leu 
305                 310                 315                 320 


Ser Asp Lys Gly Arg Asp Gly Lys Tyr Lys Ile Ile Tyr Ser Gly Glu 
                325                 330                 335     


Glu Leu Glu Cys Asn Leu Lys Asp Leu Arg Pro Ala Thr Asp Tyr His 
            340                 345                 350         


Val Arg Val Tyr Ala Met Tyr Asn Ser Val Lys Gly Ser Cys Ser Glu 
        355                 360                 365             


Pro Val Ser Phe Thr Thr His Ser Cys Ala Pro Glu Cys Pro Phe Pro 
    370                 375                 380                 


Pro Lys Leu Ala His Arg Ser Lys Ser Ser Leu Thr Leu Gln Trp Lys 
385                 390                 395                 400 


Ala Pro Ile Asp Asn Gly Ser Lys Ile Thr Asn Tyr Leu Leu Glu Trp 
                405                 410                 415     


Asp Glu Gly Lys Arg Asn Ser Gly Phe Arg Gln Cys Phe Phe Gly Ser 
            420                 425                 430         


Gln Lys His Cys Lys Leu Thr Lys Leu Cys Pro Ala Met Gly Tyr Thr 
        435                 440                 445             


Phe Arg Leu Ala Ala Arg Asn Asp Ile Gly Thr Ser Gly Tyr Ser Gln 
    450                 455                 460                 


Glu Val Val Cys Tyr Thr Leu Gly Asn Ile Pro Gln Met Pro Ser Ala 
465                 470                 475                 480 


Pro Arg Leu Val Arg Ala Gly Ile Thr Trp Val Thr Leu Gln Trp Ser 
                485                 490                 495     


Lys Pro Glu Gly Cys Ser Pro Glu Glu Val Ile Thr Tyr Thr Leu Glu 
            500                 505                 510         


Ile Gln Glu Asp Glu Asn Asp Asn Leu Phe His Pro Lys Tyr Thr Gly 
        515                 520                 525             


Glu Asp Leu Thr Cys Thr Val Lys Asn Leu Lys Arg Ser Thr Gln Tyr 
    530                 535                 540                 


Lys Phe Arg Leu Thr Ala Ser Asn Thr Glu Gly Lys Ser Cys Pro Ser 
545                 550                 555                 560 


Glu Val Leu Val Cys Thr Thr Ser Pro Asp Arg Pro Gly Pro Pro Thr 
                565                 570                 575     


Arg Pro Leu Val Lys Gly Pro Val Thr Ser His Gly Phe Ser Val Lys 
            580                 585                 590         


Trp Asp Pro Pro Lys Asp Asn Gly Gly Ser Glu Ile Leu Lys Tyr Leu 
        595                 600                 605             


Leu Glu Ile Thr Asp Gly Asn Ser Glu Ala Asn Gln Trp Glu Val Ala 
    610                 615                 620                 


Tyr Ser Gly Ser Ala Thr Glu Tyr Thr Phe Thr His Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Leu Tyr Lys Leu Arg Ala Cys Cys Ile Ser Thr Gly Gly His Ser 
                645                 650                 655     


Gln Cys Ser Glu Ser Leu Pro Val Arg Thr Leu Ser Ile Ala Pro Gly 
            660                 665                 670         


Gln Cys Arg Pro Pro Arg Val Leu Gly Arg Pro Lys His Lys Glu Val 
        675                 680                 685             


His Leu Glu Trp Asp Val Pro Ala Ser Glu Ser Gly Cys Glu Val Ser 
    690                 695                 700                 


Glu Tyr Ser Val Glu Met Thr Glu Pro Glu Asp Val Ala Ser Glu Val 
705                 710                 715                 720 


Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu Leu Pro Gly 
                725                 730                 735     


Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly Gly Tyr Gly 
            740                 745                 750         


Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly Pro Pro Gly 
        755                 760                 765             


Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly Cys Val Leu 
    770                 775                 780                 


Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile Ser Glu Tyr 
785                 790                 795                 800 


Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu Ile Tyr His 
                805                 810                 815     


Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro Ala Ala Gln 
            820                 825                 830         


Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala Gly Pro Tyr 
        835                 840                 845             


Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro Asp Pro Val 
    850                 855                 860                 


Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala Tyr Pro Asp 
865                 870                 875                 880 


Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro Cys Asn Asn 
                885                 890                 895     


Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp Thr Ser Ile 
            900                 905                 910         


Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu Leu Pro Glu 
        915                 920                 925             


Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile Gly Ala Gly 
    930                 935                 940                 


Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu Pro Pro Leu 
945                 950                 955                 960 


Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser Leu Lys Leu 
                965                 970                 975     


Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu Asp Ile Val 
            980                 985                 990         


Tyr Thr Leu Gln Leu Glu Asp Arg  Asn Lys Arg Phe Ile  Ser Ile Tyr 
        995                 1000                 1005             


Arg Gly  Pro Ser His Thr Tyr  Lys Val Gln Arg Leu  Thr Glu Phe 
    1010                 1015                 1020             


Thr Cys  Tyr Ser Phe Arg Ile  Gln Ala Ala Ser Glu  Ala Gly Glu 
    1025                 1030                 1035             


Gly Pro  Phe Ser Glu Thr Tyr  Thr Phe Ser Thr Thr  Lys Ser Val 
    1040                 1045                 1050             


Pro Pro  Thr Ile Lys Ala Pro  Arg Val Thr Gln Leu  Glu Gly Asn 
    1055                 1060                 1065             


Ser Cys  Glu Ile Leu Trp Glu  Thr Val Pro Ser Met  Lys Gly Asp 
    1070                 1075                 1080             


Pro Val  Asn Tyr Ile Leu Gln  Val Leu Val Gly Arg  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Lys  Gln Val Tyr Lys Gly  Glu Glu Ala Thr Phe  Gln Ile Ser 
    1100                 1105                 1110             


Gly Leu  Gln Thr Asn Thr Asp  Tyr Arg Phe Arg Val  Cys Ala Cys 
    1115                 1120                 1125             


Arg Arg  Cys Leu Asp Thr Ser  Gln Glu Leu Ser Gly  Ala Phe Ser 
    1130                 1135                 1140             


Pro Ser  Ala Ala Phe Val Leu  Gln Arg Ser Glu Val  Met Leu Thr 
    1145                 1150                 1155             


Gly Asp  Met Gly Ser Leu Asp  Asp Pro Lys Met Lys  Ser Met Met 
    1160                 1165                 1170             


Pro Thr  Asp Glu Gln Phe Ala  Ala Ile Ile Val Leu  Gly Phe Ala 
    1175                 1180                 1185             


Thr Leu  Ser Ile Leu Phe Ala  Phe Ile Leu Gln Tyr  Phe Leu Met 
    1190                 1195                 1200             


Lys 
    


<210>  4120
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNDC4__Homo_sapiens__NP_073734

<400>  4120

Met Pro Ser Gly Cys His Ser Ser Pro Pro Ser Gly Leu Arg Gly Asp 
1               5                   10                  15      


Met Ala Ser Leu Val Pro Leu Ser Pro Tyr Leu Ser Pro Thr Val Leu 
            20                  25                  30          


Leu Leu Val Ser Cys Asp Leu Gly Phe Val Arg Ala Asp Arg Pro Pro 
        35                  40                  45              


Ser Pro Val Asn Val Thr Val Thr His Leu Arg Ala Asn Ser Ala Thr 
    50                  55                  60                  


Val Ser Trp Asp Val Pro Glu Gly Asn Ile Val Ile Gly Tyr Ser Ile 
65                  70                  75                  80  


Ser Gln Gln Arg Gln Asn Gly Pro Gly Gln Arg Val Ile Arg Glu Val 
                85                  90                  95      


Asn Thr Thr Thr Arg Ala Cys Ala Leu Trp Gly Leu Ala Glu Asp Ser 
            100                 105                 110         


Asp Tyr Thr Val Gln Val Arg Ser Ile Gly Leu Arg Gly Glu Ser Pro 
        115                 120                 125             


Pro Gly Pro Arg Val His Phe Arg Thr Leu Lys Gly Ser Asp Arg Leu 
    130                 135                 140                 


Pro Ser Asn Ser Ser Ser Pro Gly Asp Ile Thr Val Glu Gly Leu Asp 
145                 150                 155                 160 


Gly Glu Arg Pro Leu Gln Thr Gly Glu Val Val Ile Ile Val Val Val 
                165                 170                 175     


Leu Leu Met Trp Ala Ala Val Ile Gly Leu Phe Cys Arg Gln Tyr Asp 
            180                 185                 190         


Ile Ile Lys Asp Asn Asp Ser Asn Asn Asn Pro Lys Glu Lys Gly Lys 
        195                 200                 205             


Gly Pro Glu Gln Ser Pro Gln Gly Arg Pro Val Gly Thr Arg Gln Lys 
    210                 215                 220                 


Lys Ser Pro Ser Ile Asn Thr Ile Asp Val 
225                 230                 


<210>  4121
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNTA__Homo_sapiens__NP_002018

<400>  4121

Met Ala Ala Thr Glu Gly Val Gly Glu Ala Ala Gln Gly Gly Glu Pro 
1               5                   10                  15      


Gly Gln Pro Ala Gln Pro Pro Pro Gln Pro His Pro Pro Pro Pro Gln 
            20                  25                  30          


Gln Gln His Lys Glu Glu Met Ala Ala Glu Ala Gly Glu Ala Val Ala 
        35                  40                  45              


Ser Pro Met Asp Asp Gly Phe Val Ser Leu Asp Ser Pro Ser Tyr Val 
    50                  55                  60                  


Leu Tyr Arg Asp Arg Ala Glu Trp Ala Asp Ile Asp Pro Val Pro Gln 
65                  70                  75                  80  


Asn Asp Gly Pro Asn Pro Val Val Gln Ile Ile Tyr Ser Asp Lys Phe 
                85                  90                  95      


Arg Asp Val Tyr Asp Tyr Phe Arg Ala Val Leu Gln Arg Asp Glu Arg 
            100                 105                 110         


Ser Glu Arg Ala Phe Lys Leu Thr Arg Asp Ala Ile Glu Leu Asn Ala 
        115                 120                 125             


Ala Asn Tyr Thr Val Trp His Phe Arg Arg Val Leu Leu Lys Ser Leu 
    130                 135                 140                 


Gln Lys Asp Leu His Glu Glu Met Asn Tyr Ile Thr Ala Ile Ile Glu 
145                 150                 155                 160 


Glu Gln Pro Lys Asn Tyr Gln Val Trp His His Arg Arg Val Leu Val 
                165                 170                 175     


Glu Trp Leu Arg Asp Pro Ser Gln Glu Leu Glu Phe Ile Ala Asp Ile 
            180                 185                 190         


Leu Asn Gln Asp Ala Lys Asn Tyr His Ala Trp Gln His Arg Gln Trp 
        195                 200                 205             


Val Ile Gln Glu Phe Lys Leu Trp Asp Asn Glu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Gln Leu Leu Lys Glu Asp Val Arg Asn Asn Ser Val Trp Asn Gln Arg 
225                 230                 235                 240 


Tyr Phe Val Ile Ser Asn Thr Thr Gly Tyr Asn Asp Arg Ala Val Leu 
                245                 250                 255     


Glu Arg Glu Val Gln Tyr Thr Leu Glu Met Ile Lys Leu Val Pro His 
            260                 265                 270         


Asn Glu Ser Ala Trp Asn Tyr Leu Lys Gly Ile Leu Gln Asp Arg Gly 
        275                 280                 285             


Leu Ser Lys Tyr Pro Asn Leu Leu Asn Gln Leu Leu Asp Leu Gln Pro 
    290                 295                 300                 


Ser His Ser Ser Pro Tyr Leu Ile Ala Phe Leu Val Asp Ile Tyr Glu 
305                 310                 315                 320 


Asp Met Leu Glu Asn Gln Cys Asp Asn Lys Glu Asp Ile Leu Asn Lys 
                325                 330                 335     


Ala Leu Glu Leu Cys Glu Ile Leu Ala Lys Glu Lys Asp Thr Ile Arg 
            340                 345                 350         


Lys Glu Tyr Trp Arg Tyr Ile Gly Arg Ser Leu Gln Ser Lys His Ser 
        355                 360                 365             


Thr Glu Asn Asp Ser Pro Thr Asn Val Gln Gln 
    370                 375                 


<210>  4122
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNTB__Homo_sapiens__NP_002019

<400>  4122

Met Ala Ser Pro Ser Ser Phe Thr Tyr Tyr Cys Pro Pro Ser Ser Ser 
1               5                   10                  15      


Pro Val Trp Ser Glu Pro Leu Tyr Ser Leu Arg Pro Glu His Ala Arg 
            20                  25                  30          


Glu Arg Leu Gln Asp Asp Ser Val Glu Thr Val Thr Ser Ile Glu Gln 
        35                  40                  45              


Ala Lys Val Glu Glu Lys Ile Gln Glu Val Phe Ser Ser Tyr Lys Phe 
    50                  55                  60                  


Asn His Leu Val Pro Arg Leu Val Leu Gln Arg Glu Lys His Phe His 
65                  70                  75                  80  


Tyr Leu Lys Arg Gly Leu Arg Gln Leu Thr Asp Ala Tyr Glu Cys Leu 
                85                  90                  95      


Asp Ala Ser Arg Pro Trp Leu Cys Tyr Trp Ile Leu His Ser Leu Glu 
            100                 105                 110         


Leu Leu Asp Glu Pro Ile Pro Gln Ile Val Ala Thr Asp Val Cys Gln 
        115                 120                 125             


Phe Leu Glu Leu Cys Gln Ser Pro Glu Gly Gly Phe Gly Gly Gly Pro 
    130                 135                 140                 


Gly Gln Tyr Pro His Leu Ala Pro Thr Tyr Ala Ala Val Asn Ala Leu 
145                 150                 155                 160 


Cys Ile Ile Gly Thr Glu Glu Ala Tyr Asp Ile Ile Asn Arg Glu Lys 
                165                 170                 175     


Leu Leu Gln Tyr Leu Tyr Ser Leu Lys Gln Pro Asp Gly Ser Phe Leu 
            180                 185                 190         


Met His Val Gly Gly Glu Val Asp Val Arg Ser Ala Tyr Cys Ala Ala 
        195                 200                 205             


Ser Val Ala Ser Leu Thr Asn Ile Ile Thr Pro Asp Leu Phe Glu Gly 
    210                 215                 220                 


Thr Ala Glu Trp Ile Ala Arg Cys Gln Asn Trp Glu Gly Gly Ile Gly 
225                 230                 235                 240 


Gly Val Pro Gly Met Glu Ala His Gly Gly Tyr Thr Phe Cys Gly Leu 
                245                 250                 255     


Ala Ala Leu Val Ile Leu Lys Arg Glu Arg Ser Leu Asn Leu Lys Ser 
            260                 265                 270         


Leu Leu Gln Trp Val Thr Ser Arg Gln Met Arg Phe Glu Gly Gly Phe 
        275                 280                 285             


Gln Gly Arg Cys Asn Lys Leu Val Asp Gly Cys Tyr Ser Phe Trp Gln 
    290                 295                 300                 


Ala Gly Leu Leu Pro Leu Leu His Arg Ala Leu His Ala Gln Gly Asp 
305                 310                 315                 320 


Pro Ala Leu Ser Met Ser His Trp Met Phe His Gln Gln Ala Leu Gln 
                325                 330                 335     


Glu Tyr Ile Leu Met Cys Cys Gln Cys Pro Ala Gly Gly Leu Leu Asp 
            340                 345                 350         


Lys Pro Gly Lys Ser Arg Asp Phe Tyr His Thr Cys Tyr Cys Leu Ser 
        355                 360                 365             


Gly Leu Ser Ile Ala Gln His Phe Gly Ser Gly Ala Met Leu His Asp 
    370                 375                 380                 


Val Val Leu Gly Val Pro Glu Asn Ala Leu Gln Pro Thr His Pro Val 
385                 390                 395                 400 


Tyr Asn Ile Gly Pro Asp Lys Val Ile Gln Ala Thr Thr Tyr Phe Leu 
                405                 410                 415     


Gln Lys Pro Val Pro Gly Phe Glu Glu Leu Lys Asp Glu Thr Ser Ala 
            420                 425                 430         


Glu Pro Ala Thr Asp 
        435         


<210>  4123
<211>  1801
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOCAD__Homo_sapiens__NP_060264

<400>  4123

Met Ser Asp Asp Ile Arg Lys Arg Phe Glu Phe Pro Asn Ser Leu Ile 
1               5                   10                  15      


Gln Ser Gln Ala Val Gly His Leu Ile Ala Ala Val Leu Lys Glu Asn 
            20                  25                  30          


Gly Phe Ser Glu Lys Ile His Gln Ser Thr Asn Gln Thr Pro Ala Leu 
        35                  40                  45              


Asn Leu Leu Trp Glu Lys Cys Cys Ser Asp Asn Val Val Val Arg Thr 
    50                  55                  60                  


Ala Cys Cys Glu Gly Leu Val Ala Leu Val Ala Gln Asp His Ala Glu 
65                  70                  75                  80  


Phe Ser Tyr Val Leu Asn Gly Ile Leu Asn Leu Ile Pro Ser Thr Arg 
                85                  90                  95      


Asn Thr His Gly Leu Ile Lys Ala Ile Met His Leu Leu Gln Met Gln 
            100                 105                 110         


Ala Leu Lys Glu Gly Gln Gly Gly Glu Lys Asn Ile Gln Ser Ile Tyr 
        115                 120                 125             


Thr Ile Arg Asn His Pro His Pro Leu Ile Thr Val Leu Glu His Arg 
    130                 135                 140                 


Pro Asp Cys Trp Pro Val Phe Leu Gln Gln Leu Thr Ala Phe Phe Gln 
145                 150                 155                 160 


Gln Cys Pro Glu Arg Leu Glu Val Ser Cys Ile Gln Ile Met Ala Pro 
                165                 170                 175     


Phe Leu Trp Tyr Leu Tyr Cys Glu Pro Ser Gln Leu Gln Glu Tyr Ala 
            180                 185                 190         


Lys Leu Arg Leu Ala Leu Leu Lys Val Leu Leu Gln Pro Gln Val Leu 
        195                 200                 205             


Cys Asp Lys Asp Gln Pro Ser Ile Leu Glu Gln Gln Ile Leu Gln Leu 
    210                 215                 220                 


Cys Cys Asp Ile Val Pro Cys Leu Gln Val Lys Asp Leu Ile Gln Thr 
225                 230                 235                 240 


Thr Glu Ala Met Met Phe Ile Glu Glu Val Cys Leu Ser Leu Leu Arg 
                245                 250                 255     


His Pro Val Phe Trp Lys Ile Gln Leu Thr Gln Met Ser Leu Gln Leu 
            260                 265                 270         


Leu Cys Val Ser Glu Val Ser Leu Lys Ile Thr Gly Glu Cys Ser Ser 
        275                 280                 285             


Ser Ile His Leu Leu Glu His Ser Val Glu Leu Leu Lys Glu Asp Phe 
    290                 295                 300                 


Pro Val Glu Leu Val Ile Ile Gly Ile Ala Leu Leu Leu Leu Gln Thr 
305                 310                 315                 320 


Pro Ala Ser Gln Gln Lys Pro Ile Leu Asn Leu Ala Leu Lys Leu Leu 
                325                 330                 335     


Ser Val Thr Glu Asp Gln Lys Ile Pro Lys Ser Ser Leu Leu Leu Val 
            340                 345                 350         


Met Pro Ile Leu Gln Ile Leu Ser Ser Thr Ala Leu Glu Asp Cys Ile 
        355                 360                 365             


Ser Val Asp Glu Glu Gly Pro Ser Arg Gln Gln Leu Ala Leu Asn Leu 
    370                 375                 380                 


Leu Glu Met Ile Gln Gln Glu Cys Tyr Arg Asp Asp His Gln Lys Leu 
385                 390                 395                 400 


Ser Tyr Lys Leu Val Cys Pro Val Thr Ser Met Tyr Gly Thr Ile Phe 
                405                 410                 415     


Thr Ala Trp Arg Ile Leu Glu Val Met Thr Asp Ser Ser Ala Ala Ser 
            420                 425                 430         


Asp Trp Leu Ala Ser Val Glu Ser Leu Leu Pro Ile Thr Ala Val Ile 
        435                 440                 445             


Pro Ala Pro Ala Phe Leu Leu Leu Ala His Leu Leu Val Glu Asp Lys 
    450                 455                 460                 


Gly Gln Asn Leu His Gln Ile Leu Lys Val Thr Thr Glu Leu Ala Gln 
465                 470                 475                 480 


Ala Asp Ser Ser Gln Val Pro Asn Leu Ile Pro Val Leu Met Phe Lys 
                485                 490                 495     


Leu Gly Arg Pro Leu Glu Pro Ile Leu Tyr Asn Asp Ile Leu Tyr Thr 
            500                 505                 510         


Leu Pro Lys Leu Gly Val His Lys Val Cys Ile Gly Gln Ile Leu Arg 
        515                 520                 525             


Ile Ile Gln Leu Leu Gly Thr Thr Pro Arg Leu Arg Ala Val Thr Leu 
    530                 535                 540                 


Arg Leu Leu Thr Ser Leu Trp Glu Lys Gln Asp Arg Val Tyr Pro Glu 
545                 550                 555                 560 


Leu Gln Arg Phe Met Ala Val Ser Asp Val Pro Ser Leu Ser Val Gly 
                565                 570                 575     


Lys Glu Val Gln Trp Glu Lys Leu Ile Ala Lys Ala Ala Ser Ile Arg 
            580                 585                 590         


Asp Ile Cys Lys Gln Arg Pro Tyr Gln His Gly Ala Asp Met Leu Ala 
        595                 600                 605             


Ala Ile Ser Gln Val Leu Asn Glu Cys Thr Lys Pro Asp Gln Ala Thr 
    610                 615                 620                 


Pro Ala Ala Leu Val Leu Gln Gly Leu His Ala Leu Cys Gln Ala Glu 
625                 630                 635                 640 


Val Val Cys Ile Arg Ser Thr Trp Asn Ala Leu Ser Pro Lys Leu Ser 
                645                 650                 655     


Cys Asp Thr Arg Pro Leu Ile Leu Lys Thr Leu Ser Glu Leu Phe Ser 
            660                 665                 670         


Leu Val Pro Ser Leu Thr Val Asn Thr Thr Glu Tyr Glu Asn Phe Lys 
        675                 680                 685             


Val Gln Val Leu Ser Phe Leu Trp Thr His Thr Gln Asn Lys Asp Pro 
    690                 695                 700                 


Ile Val Ala Asn Ala Ala Tyr Arg Ser Leu Ala Asn Phe Ser Ala Gly 
705                 710                 715                 720 


Glu His Thr Ile Leu His Leu Pro Glu Lys Ile Arg Pro Glu Ile Pro 
                725                 730                 735     


Ile Pro Glu Glu Leu Asp Asp Asp Glu Asp Val Glu Asp Val Asp Leu 
            740                 745                 750         


Ser Val Pro Gly Ser Cys Tyr Leu Lys Leu Leu Ser Leu Thr Pro Pro 
        755                 760                 765             


Leu Val Leu Pro Ala Leu Glu Glu Phe Phe Thr Ser Leu Val Lys Gln 
    770                 775                 780                 


Glu Met Val Asn Met Pro Arg Gly Ile Tyr His Ser Ala Leu Lys Gly 
785                 790                 795                 800 


Gly Ala Arg Ser Asp Gln Gly Lys Thr Val Ala Gly Ile Pro Asn Phe 
                805                 810                 815     


Ile Leu Lys Met Tyr Glu Thr Asn Lys Gln Pro Gly Leu Lys Pro Gly 
            820                 825                 830         


Leu Ala Gly Gly Met Leu Phe Cys Tyr Asp Val Ser Met Tyr Gln Ser 
        835                 840                 845             


Lys Asp Gly Lys Pro Leu Asn Arg Leu Met Ala Ser Arg Gly Arg Ser 
    850                 855                 860                 


Phe Lys Gln Thr Ser Leu Ala Leu Val His Glu Val His Ile Gln Leu 
865                 870                 875                 880 


Ser Glu Trp His Arg Ala Ile Phe Leu Pro Gln Ala Trp Leu Ala Tyr 
                885                 890                 895     


Met Asn Arg Ala Tyr His Ala Ile Leu Gln Gly Arg Leu Gly Glu Leu 
            900                 905                 910         


Glu Leu Gln Leu Lys His Gly Lys Glu Glu Pro Glu Glu Val Gln Tyr 
        915                 920                 925             


Lys Lys Ser Thr Ala Trp Leu Trp Val Arg Asp Met Leu Thr Asp Glu 
    930                 935                 940                 


Ile Thr Lys Ala Ala Ala Lys Glu Ser Pro Val Val Lys Gly Asn Ala 
945                 950                 955                 960 


Leu Leu Ala Leu Ser Ser Leu Ala Val Val Val Ser Arg His Glu Ala 
                965                 970                 975     


Ser Leu Ser Ser Asp Ser Asp Gly Leu Leu Glu Val Gln Pro Asn Phe 
            980                 985                 990         


Leu Ser Met Lys Glu Trp Val Ser  Met Val Leu Asp Thr  Leu Leu Val 
        995                 1000                 1005             


Ile Val  Asp Ser His Tyr Gln  Pro Arg Gly Gln Leu  Leu Ser Trp 
    1010                 1015                 1020             


Phe Tyr  Tyr Lys Ser Tyr Ser  Gly Glu Asn Thr Ala  Ser Ala Ile 
    1025                 1030                 1035             


Ala Arg  Ser Ala Ala Ala Thr  Ala Leu Ser Leu Leu  Val Pro Val 
    1040                 1045                 1050             


Phe Ile  Ile Ser Cys Lys Glu  Lys Val Glu Glu Ile  Leu Asn Met 
    1055                 1060                 1065             


Leu Thr  Ala Arg Leu Pro Gly  Lys Pro Ser Ala Asp  Glu Ser Gln 
    1070                 1075                 1080             


Ala Val  Gln Ile His Met Gly  Leu Ala Leu Gly Met  Phe Leu Ser 
    1085                 1090                 1095             


Arg Leu  Cys Glu Glu Lys Leu  Ser Asp Ile Ser Gly  Gln Glu Met 
    1100                 1105                 1110             


Asn Leu  Leu Leu Met Lys Ser  Leu Asp Ala Leu Glu  Asn Cys Cys 
    1115                 1120                 1125             


Phe Asp  Thr Ser Leu Glu Tyr  Asn Thr Gly Cys Ile  Leu Gly Val 
    1130                 1135                 1140             


Gly Leu  Val Leu Ser Leu Met  Ser His Ser Ser Gln  Met Gln Ser 
    1145                 1150                 1155             


Arg Val  His Val Ala Ala Leu  Leu Arg Lys Leu Ser  Ala His Val 
    1160                 1165                 1170             


Asp Asp  Ser Gly Ser Gln Ser  Arg Thr Phe Gln Glu  Val Leu Ala 
    1175                 1180                 1185             


Tyr Thr  Leu Ser Cys Val Cys  Thr Ser Ala Phe Ser  Ala Gly Ile 
    1190                 1195                 1200             


Ile Glu  Ala Thr Glu Ala Glu  Asp Val Met Asn Lys  Leu Arg Leu 
    1205                 1210                 1215             


Leu Val  Glu Asn Ser Gln Gln  Thr Ser Gly Phe Ala  Leu Ala Leu 
    1220                 1225                 1230             


Gly Asn  Ile Val His Gly Leu  Ser Val Cys Gly His  Gly Lys Ala 
    1235                 1240                 1245             


Glu Asp  Leu Gly Ser Lys Leu  Leu Pro Ala Trp Ile  Arg Ile Val 
    1250                 1255                 1260             


Leu Thr  Glu Gly Thr Pro Thr  Met Leu Cys Leu Ala  Ala Leu His 
    1265                 1270                 1275             


Gly Met  Val Ala Leu Val Gly  Ser Glu Gly Asp Val  Met Gln Leu 
    1280                 1285                 1290             


Lys Ser  Glu Ala Ile Gln Thr  Ser His Phe Gln Gly  Arg Leu Asn 
    1295                 1300                 1305             


Glu Val  Ile Arg Thr Leu Thr  Gln Val Ile Ser Val  Ser Gly Val 
    1310                 1315                 1320             


Ile Gly  Leu Gln Ser Asn Ala  Val Trp Leu Leu Gly  His Leu His 
    1325                 1330                 1335             


Leu Ser  Thr Leu Ser Ser Ser  Gln Ser Arg Ala Ser  Val Pro Thr 
    1340                 1345                 1350             


Asp Tyr  Ser Tyr Leu Pro Glu  Ser Ser Phe Ile Gly  Ala Ala Ile 
    1355                 1360                 1365             


Gly Phe  Phe Ile Thr Gly Gly  Lys Lys Gly Pro Glu  Ser Val Pro 
    1370                 1375                 1380             


Pro Ser  Leu Leu Lys Val Val  Met Lys Pro Ile Ala  Thr Val Gly 
    1385                 1390                 1395             


Glu Ser  Tyr Gln Tyr Pro Pro  Val Asn Trp Ala Ala  Leu Leu Ser 
    1400                 1405                 1410             


Pro Leu  Met Arg Leu Asn Phe  Gly Glu Glu Ile Gln  Gln Leu Cys 
    1415                 1420                 1425             


Leu Glu  Ile Met Val Thr Gln  Ala Gln Ser Ser Gln  Asn Ala Ala 
    1430                 1435                 1440             


Ala Leu  Leu Gly Leu Trp Val  Thr Pro Pro Leu Ile  His Ser Leu 
    1445                 1450                 1455             


Ser Leu  Asn Thr Lys Arg Tyr  Leu Leu Ile Ser Ala  Pro Leu Trp 
    1460                 1465                 1470             


Ile Lys  His Ile Ser Asp Glu  Gln Ile Leu Gly Phe  Val Glu Asn 
    1475                 1480                 1485             


Leu Met  Val Ala Val Phe Lys  Ala Ala Ser Pro Leu  Gly Ser Pro 
    1490                 1495                 1500             


Glu Leu  Cys Pro Ser Ala Leu  His Gly Leu Ser Gln  Ala Met Lys 
    1505                 1510                 1515             


Leu Pro  Ser Pro Ala His His  Leu Trp Ser Leu Leu  Ser Glu Ala 
    1520                 1525                 1530             


Thr Gly  Lys Ile Phe Asp Leu  Leu Pro Asn Lys Ile  Arg Arg Lys 
    1535                 1540                 1545             


Asp Leu  Glu Leu Tyr Ile Ser  Ile Ala Lys Cys Leu  Leu Glu Met 
    1550                 1555                 1560             


Thr Asp  Asp Asp Ala Asn Arg  Ile Ala Gln Val Thr  Lys Ser Asn 
    1565                 1570                 1575             


Ile Glu  Lys Ala Ala Phe Val  Lys Leu Tyr Leu Val  Ser Gln Gly 
    1580                 1585                 1590             


Arg Phe  Pro Leu Val Asn Leu  Thr Asp Met Leu Ser  Val Ala Val 
    1595                 1600                 1605             


Gln His  Arg Glu Lys Glu Val  Leu Ala Trp Met Ile  Leu His Ser 
    1610                 1615                 1620             


Leu Tyr  Gln Ala Arg Ile Val  Ser His Ala Asn Thr  Gly Val Leu 
    1625                 1630                 1635             


Lys Arg  Met Glu Trp Leu Leu  Glu Leu Met Gly Tyr  Ile Arg Asn 
    1640                 1645                 1650             


Val Ala  Tyr Gln Ser Thr Ser  Phe His Asn Thr Ala  Leu Asp Lys 
    1655                 1660                 1665             


Ala Leu  Asp Phe Phe Leu Leu  Ile Phe Ala Thr Ala  Val Val Ala 
    1670                 1675                 1680             


Trp Ala  Asp His Thr Ala Pro  Leu Leu Leu Gly Leu  Ser Ala Ser 
    1685                 1690                 1695             


Trp Leu  Pro Trp His Gln Glu  Asn Gly Pro Ala Gly  Pro Val Pro 
    1700                 1705                 1710             


Ser Phe  Leu Gly Arg Ser Pro  Met His Arg Val Thr  Leu Gln Glu 
    1715                 1720                 1725             


Val Leu  Thr Leu Leu Pro Asn  Ser Met Ala Leu Leu  Leu Gln Lys 
    1730                 1735                 1740             


Glu Pro  Trp Lys Glu Gln Thr  Gln Lys Phe Ile Asp  Trp Leu Phe 
    1745                 1750                 1755             


Ser Ile  Met Glu Ser Pro Lys  Glu Ala Leu Ser Ala  Gln Ser Arg 
    1760                 1765                 1770             


Asp Leu  Leu Lys Ala Thr Leu  Leu Ser Leu Arg Val  Leu Pro Glu 
    1775                 1780                 1785             


Phe Lys  Lys Lys Ala Val Trp  Thr Arg Ala Tyr Gly  Trp 
    1790                 1795                 1800     


<210>  4124
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOLH1__Homo_sapiens__NP_001014986

<400>  4124

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
            660                 665                 670         


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
        675                 680                 685             


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
    690                 695                 700                 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
705                 710                 715                 


<210>  4125
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOLR1__Homo_sapiens__NP_000793

<400>  4125

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  4126
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOLR2__Homo_sapiens__NP_001107008

<400>  4126

Met Val Trp Lys Trp Met Pro Leu Leu Leu Leu Leu Val Cys Val Ala 
1               5                   10                  15      


Thr Met Cys Ser Ala Gln Asp Arg Thr Asp Leu Leu Asn Val Cys Met 
            20                  25                  30          


Asp Ala Lys His His Lys Thr Lys Pro Gly Pro Glu Asp Lys Leu His 
        35                  40                  45              


Asp Gln Cys Ser Pro Trp Lys Lys Asn Ala Cys Cys Thr Ala Ser Thr 
    50                  55                  60                  


Ser Gln Glu Leu His Lys Asp Thr Ser Arg Leu Tyr Asn Phe Asn Trp 
65                  70                  75                  80  


Asp His Cys Gly Lys Met Glu Pro Ala Cys Lys Arg His Phe Ile Gln 
                85                  90                  95      


Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln 
            100                 105                 110         


Gln Val Asn Gln Ser Trp Arg Lys Glu Arg Phe Leu Asp Val Pro Leu 
        115                 120                 125             


Cys Lys Glu Asp Cys Gln Arg Trp Trp Glu Asp Cys His Thr Ser His 
    130                 135                 140                 


Thr Cys Lys Ser Asn Trp His Arg Gly Trp Asp Trp Thr Ser Gly Val 
145                 150                 155                 160 


Asn Lys Cys Pro Ala Gly Ala Leu Cys Arg Thr Phe Glu Ser Tyr Phe 
                165                 170                 175     


Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu Trp Ser His Ser Tyr Lys 
            180                 185                 190         


Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile Gln Met Trp Phe 
        195                 200                 205             


Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu Val Ala Arg Phe Tyr Ala 
    210                 215                 220                 


Ala Ala Met His Val Asn Ala Gly Glu Met Leu His Gly Thr Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Ser Leu Ala Leu Met Leu Gln Leu Trp Leu Leu Gly 
                245                 250                 255 


<210>  4127
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOLR3__Homo_sapiens__NP_000795

<400>  4127

Met Asp Met Ala Trp Gln Met Met Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Thr Ala Ala Gly Ser Ala Gln Pro Arg Ser Ala Arg Ala Arg Thr Asp 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Thr Gln Pro Ser 
        35                  40                  45              


Pro Glu Asp Glu Leu Tyr Gly Gln Cys Ser Pro Trp Lys Lys Asn Ala 
    50                  55                  60                  


Cys Cys Thr Ala Ser Thr Ser Gln Glu Leu His Lys Asp Thr Ser Arg 
65                  70                  75                  80  


Leu Tyr Asn Phe Asn Trp Asp His Cys Gly Lys Met Glu Pro Thr Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Ser Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Arg Gln Val Asn Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Ile Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Arg Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Ile Asn Glu Cys Pro Ala Gly Ala Leu Cys Ser 
                165                 170                 175     


Thr Phe Glu Ser Tyr Phe Pro Thr Pro Ala Ala Leu Cys Glu Gly Leu 
            180                 185                 190         


Trp Ser His Ser Phe Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Ser Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Lys Phe Tyr Ala Ala Ala Met Asn Ala Gly Ala Pro Ser Arg 
225                 230                 235                 240 


Gly Ile Ile Asp Ser 
                245 


<210>  4128
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOPNL__Homo_sapiens__NP_653201

<400>  4128

Met Ala Thr Val Ala Glu Leu Lys Ala Val Leu Lys Asp Thr Leu Glu 
1               5                   10                  15      


Lys Lys Gly Val Leu Gly His Leu Lys Ala Arg Ile Arg Ala Glu Val 
            20                  25                  30          


Phe Asn Ala Leu Asp Asp Asp Arg Glu Pro Arg Pro Ser Leu Ser His 
        35                  40                  45              


Glu Asn Leu Leu Ile Asn Glu Leu Ile Arg Glu Tyr Leu Glu Phe Asn 
    50                  55                  60                  


Lys Tyr Lys Tyr Thr Ala Ser Val Leu Ile Ala Glu Ser Gly Gln Pro 
65                  70                  75                  80  


Val Val Pro Leu Asp Arg Gln Phe Leu Ile His Glu Leu Asn Ala Phe 
                85                  90                  95      


Glu Glu Ser Lys Asp Asn Thr Ile Pro Leu Leu Tyr Gly Ile Leu Ala 
            100                 105                 110         


His Phe Leu Arg Gly Thr Lys Asp Gly Ile Gln Asn Ala Phe Leu Lys 
        115                 120                 125             


Gly Pro Ser Leu Gln Pro Ser Asp Pro Ser Leu Gly Arg Gln Pro Ser 
    130                 135                 140                 


Arg Arg Lys Pro Met Asp Asp His Leu Arg Lys Glu Glu Gln Lys Ser 
145                 150                 155                 160 


Thr Asn Ile Glu Asp Leu His Val Ser Gln Ala Val Asn Arg 
                165                 170                 


<210>  4129
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOSB__Homo_sapiens__NP_001107643

<400>  4129

Met Phe Gln Ala Phe Pro Gly Asp Tyr Asp Ser Gly Ser Arg Cys Ser 
1               5                   10                  15      


Ser Ser Pro Ser Ala Glu Ser Gln Tyr Leu Ser Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ser Pro Pro Thr Ala Ala Ala Ser Gln Glu Cys Ala Gly Leu Gly 
        35                  40                  45              


Glu Met Pro Gly Ser Phe Val Pro Thr Val Thr Ala Ile Thr Thr Ser 
    50                  55                  60                  


Gln Asp Leu Gln Trp Leu Val Gln Pro Thr Leu Ile Ser Ser Met Ala 
65                  70                  75                  80  


Gln Ser Gln Gly Gln Pro Leu Ala Ser Gln Pro Pro Val Val Asp Pro 
                85                  90                  95      


Tyr Asp Met Pro Gly Thr Ser Tyr Ser Thr Pro Gly Met Ser Gly Tyr 
            100                 105                 110         


Ser Ser Gly Gly Ala Ser Gly Ser Gly Gly Pro Ser Thr Ser Gly Thr 
        115                 120                 125             


Thr Ser Gly Pro Gly Pro Ala Arg Pro Ala Arg Ala Arg Pro Arg Arg 
    130                 135                 140                 


Pro Arg Glu Glu Thr Glu Thr Asp Gln Leu Glu Glu Glu Lys Ala Glu 
145                 150                 155                 160 


Leu Glu Ser Glu Ile Ala Glu Leu Gln Lys Glu Lys Glu Arg Leu Glu 
                165                 170                 175     


Phe Val Leu Val Ala His Lys Pro Gly Cys Lys Ile Pro Tyr Glu Glu 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Leu Ala Glu Val Arg Asp Leu Pro Gly Ser 
        195                 200                 205             


Ala Pro Ala Lys Glu Asp Gly Phe Ser Trp Leu Leu Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro Pro Leu Pro Phe Gln Thr Ser Gln Asp Ala Pro Pro Asn Leu 
225                 230                 235                 240 


Thr Ala Ser Leu Phe Thr His Ser Glu Val Gln Val Leu Gly Asp Pro 
                245                 250                 255     


Phe Pro Val Val Asn Pro Ser Tyr Thr Ser Ser Phe Val Leu Thr Cys 
            260                 265                 270         


Pro Glu Val Ser Ala Phe Ala Gly Ala Gln Arg Thr Ser Gly Ser Asp 
        275                 280                 285             


Gln Pro Ser Asp Pro Leu Asn Ser Pro Ser Leu Leu Ala Leu 
    290                 295                 300         


<210>  4130
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOS__Homo_sapiens__NP_005243

<400>  4130

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210>  4131
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOSL1__Homo_sapiens__NP_001287784

<400>  4131

Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly 
1               5                   10                  15      


Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln 
            20                  25                  30          


Gln Lys Phe His Leu Val Pro Ser Ile Asn Thr Met Ser Gly Ser Gln 
        35                  40                  45              


Glu Leu Gln Trp Met Val Gln Pro His Phe Leu Gly Pro Ser Ser Tyr 
    50                  55                  60                  


Pro Arg Pro Leu Thr Tyr Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro 
65                  70                  75                  80  


Gly Val Ile Arg Ala Leu Gly Pro Pro Pro Gly Val Arg Arg Arg Pro 
                85                  90                  95      


Cys Glu Gln Pro Gly Gly Arg Gly Ala Pro Pro Ser Lys Ala Arg Ala 
            100                 105                 110         


Glu Gln Ala Gly Cys Gly Gln Val Gln Glu Pro Glu Glu Gly Thr Asp 
        115                 120                 125             


Arg Leu Pro Ala Gly Gly Asp 
    130                 135 


<210>  4132
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOSL2__Homo_sapiens__NP_005244

<400>  4132

Met Tyr Gln Asp Tyr Pro Gly Asn Phe Asp Thr Ser Ser Arg Gly Ser 
1               5                   10                  15      


Ser Gly Ser Pro Ala His Ala Glu Ser Tyr Ser Ser Gly Gly Gly Gly 
            20                  25                  30          


Gln Gln Lys Phe Arg Val Asp Met Pro Gly Ser Gly Ser Ala Phe Ile 
        35                  40                  45              


Pro Thr Ile Asn Ala Ile Thr Thr Ser Gln Asp Leu Gln Trp Met Val 
    50                  55                  60                  


Gln Pro Thr Val Ile Thr Ser Met Ser Asn Pro Tyr Pro Arg Ser His 
65                  70                  75                  80  


Pro Tyr Ser Pro Leu Pro Gly Leu Ala Ser Val Pro Gly His Met Ala 
                85                  90                  95      


Leu Pro Arg Pro Gly Val Ile Lys Thr Ile Gly Thr Thr Val Gly Arg 
            100                 105                 110         


Arg Arg Arg Asp Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg 
        115                 120                 125             


Ile Arg Arg Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg 
    130                 135                 140                 


Arg Arg Glu Leu Thr Glu Lys Leu Gln Ala Glu Thr Glu Glu Leu Glu 
145                 150                 155                 160 


Glu Glu Lys Ser Gly Leu Gln Lys Glu Ile Ala Glu Leu Gln Lys Glu 
                165                 170                 175     


Lys Glu Lys Leu Glu Phe Met Leu Val Ala His Gly Pro Val Cys Lys 
            180                 185                 190         


Ile Ser Pro Glu Glu Arg Arg Ser Pro Pro Ala Pro Gly Leu Gln Pro 
        195                 200                 205             


Met Arg Ser Gly Gly Gly Ser Val Gly Ala Val Val Val Lys Gln Glu 
    210                 215                 220                 


Pro Leu Glu Glu Asp Ser Pro Ser Ser Ser Ser Ala Gly Leu Asp Lys 
225                 230                 235                 240 


Ala Gln Arg Ser Val Ile Lys Pro Ile Ser Ile Ala Gly Gly Phe Tyr 
                245                 250                 255     


Gly Glu Glu Pro Leu His Thr Pro Ile Val Val Thr Ser Thr Pro Ala 
            260                 265                 270         


Val Thr Pro Gly Thr Ser Asn Leu Val Phe Thr Tyr Pro Ser Val Leu 
        275                 280                 285             


Glu Gln Glu Ser Pro Ala Ser Pro Ser Glu Ser Cys Ser Lys Ala His 
    290                 295                 300                 


Arg Arg Ser Ser Ser Ser Gly Asp Gln Ser Ser Asp Ser Leu Asn Ser 
305                 310                 315                 320 


Pro Thr Leu Leu Ala Leu 
                325     


<210>  4133
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXA1__Homo_sapiens__NP_004487

<400>  4133

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser 
            20                  25                  30          


Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 
        35                  40                  45              


Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe 
    50                  55                  60                  


Asn Met Ser Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu Ser Pro Gly 
65                  70                  75                  80  


Ala Val Ala Gly Met Pro Gly Gly Ser Ala Gly Ala Met Asn Ser Met 
                85                  90                  95      


Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Ser Gly 
            100                 105                 110         


Met Gly Ala Met Gly Ala Gln Gln Ala Ala Ser Met Asn Gly Leu Gly 
        115                 120                 125             


Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr Ala 
    130                 135                 140                 


Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys 
145                 150                 155                 160 


Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr Ile 
                165                 170                 175     


Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 
        195                 200                 205             


Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe 
    210                 215                 220                 


Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys 
225                 230                 235                 240 


Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 
                245                 250                 255     


Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Pro 
            260                 265                 270         


Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala Lys 
        275                 280                 285             


Gly Gly Pro Glu Ser Arg Lys Asp Pro Ser Gly Ala Ser Asn Pro Ser 
    290                 295                 300                 


Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln Leu 
305                 310                 315                 320 


Glu Gly Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp 
                325                 330                 335     


His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Thr Pro 
            340                 345                 350         


Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu Ala 
        355                 360                 365             


Ser Val Pro Ala Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser 
    370                 375                 380                 


Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro Phe 
385                 390                 395                 400 


Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp 
                405                 410                 415     


Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser Thr 
            420                 425                 430         


Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr Thr Arg Ser 
        435                 440                 445             


Pro Ile Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr 
    450                 455                 460                 


Ser Arg Pro Val Leu Asn Thr Ser 
465                 470         


<210>  4134
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXA2__Homo_sapiens__NP_068556

<400>  4134

Met His Ser Ala Ser Ser Met Leu Gly Ala Val Lys Met Glu Gly His 
1               5                   10                  15      


Glu Pro Ser Asp Trp Ser Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser 
            20                  25                  30          


Ser Val Ser Asn Met Asn Ala Gly Leu Gly Met Asn Gly Met Asn Thr 
        35                  40                  45              


Tyr Met Ser Met Ser Ala Ala Ala Met Gly Ser Gly Ser Gly Asn Met 
    50                  55                  60                  


Ser Ala Gly Ser Met Asn Met Ser Ser Tyr Val Gly Ala Gly Met Ser 
65                  70                  75                  80  


Pro Ser Leu Ala Gly Met Ser Pro Gly Ala Gly Ala Met Ala Gly Met 
                85                  90                  95      


Gly Gly Ser Ala Gly Ala Ala Gly Val Ala Gly Met Gly Pro His Leu 
            100                 105                 110         


Ser Pro Ser Leu Ser Pro Leu Gly Gly Gln Ala Ala Gly Ala Met Gly 
        115                 120                 125             


Gly Leu Ala Pro Tyr Ala Asn Met Asn Ser Met Ser Pro Met Tyr Gly 
    130                 135                 140                 


Gln Ala Gly Leu Ser Arg Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser 
145                 150                 155                 160 


Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
                165                 170                 175     


Ala Ile Gln Gln Ser Pro Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr 
            180                 185                 190         


Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg 
        195                 200                 205             


Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Leu 
    210                 215                 220                 


Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr 
225                 230                 235                 240 


Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
                245                 250                 255     


Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala 
            260                 265                 270         


Ala Gly Ala Ala Gly Ser Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala 
        275                 280                 285             


Ser Gln Ala Gln Leu Gly Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro 
    290                 295                 300                 


Ala Gly Thr Glu Ser Pro His Ser Ser Ala Ser Pro Cys Gln Glu His 
305                 310                 315                 320 


Lys Arg Gly Gly Leu Gly Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu 
                325                 330                 335     


Ser Pro Pro Glu Pro Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala 
            340                 345                 350         


Ala His Leu Leu Gly Pro Pro His His Pro Gly Leu Pro Pro Glu Ala 
        355                 360                 365             


His Leu Lys Pro Glu His His Tyr Ala Phe Asn His Pro Phe Ser Ile 
    370                 375                 380                 


Asn Asn Leu Met Ser Ser Glu Gln Gln His His His Ser His His His 
385                 390                 395                 400 


His Gln Pro His Lys Met Asp Leu Lys Ala Tyr Glu Gln Val Met His 
                405                 410                 415     


Tyr Pro Gly Tyr Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro 
            420                 425                 430         


Val Thr Asn Lys Thr Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr 
        435                 440                 445             


Ser Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 460             


<210>  4135
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXA3__Homo_sapiens__NP_004488

<400>  4135

Met Leu Gly Ser Val Lys Met Glu Ala His Asp Leu Ala Glu Trp Ser 
1               5                   10                  15      


Tyr Tyr Pro Glu Ala Gly Glu Val Tyr Ser Pro Val Thr Pro Val Pro 
            20                  25                  30          


Thr Met Ala Pro Leu Asn Ser Tyr Met Thr Leu Asn Pro Leu Ser Ser 
        35                  40                  45              


Pro Tyr Pro Pro Gly Gly Leu Pro Ala Ser Pro Leu Pro Ser Gly Pro 
    50                  55                  60                  


Leu Ala Pro Pro Ala Pro Ala Ala Pro Leu Gly Pro Thr Phe Pro Gly 
65                  70                  75                  80  


Leu Gly Val Ser Gly Gly Ser Ser Ser Ser Gly Tyr Gly Ala Pro Gly 
                85                  90                  95      


Pro Gly Leu Val His Gly Lys Glu Met Pro Lys Gly Tyr Arg Arg Pro 
            100                 105                 110         


Leu Ala His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
        115                 120                 125             


Ala Ile Gln Gln Ala Pro Gly Lys Met Leu Thr Leu Ser Glu Ile Tyr 
    130                 135                 140                 


Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg Glu Asn Gln Gln Arg 
145                 150                 155                 160 


Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Val 
                165                 170                 175     


Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Tyr Trp Ala 
            180                 185                 190         


Leu His Pro Ser Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
        195                 200                 205             


Arg Gln Lys Arg Phe Lys Leu Glu Glu Lys Val Lys Lys Gly Gly Ser 
    210                 215                 220                 


Gly Ala Ala Thr Thr Thr Arg Asn Gly Thr Gly Ser Ala Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Pro Ala Ala Thr Val Thr Ser Pro Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Ala Pro Glu Pro Glu Ala Gln Gly Gly Glu Asp Val Gly Ala Leu Asp 
            260                 265                 270         


Cys Gly Ser Pro Ala Ser Ser Thr Pro Tyr Phe Thr Gly Leu Glu Leu 
        275                 280                 285             


Pro Gly Glu Leu Lys Leu Asp Ala Pro Tyr Asn Phe Asn His Pro Phe 
    290                 295                 300                 


Ser Ile Asn Asn Leu Met Ser Glu Gln Thr Pro Ala Pro Pro Lys Leu 
305                 310                 315                 320 


Asp Val Gly Phe Gly Gly Tyr Gly Ala Glu Gly Gly Glu Pro Gly Val 
                325                 330                 335     


Tyr Tyr Gln Gly Leu Tyr Ser Arg Ser Leu Leu Asn Ala Ser 
            340                 345                 350 


<210>  4136
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXB1__Homo_sapiens__NP_036314

<400>  4136

Met Pro Arg Pro Gly Arg Asn Thr Tyr Ser Asp Gln Lys Pro Pro Tyr 
1               5                   10                  15      


Ser Tyr Ile Ser Leu Thr Ala Met Ala Ile Gln Ser Ser Pro Glu Lys 
            20                  25                  30          


Met Leu Pro Leu Ser Glu Ile Tyr Lys Phe Ile Met Asp Arg Phe Pro 
        35                  40                  45              


Tyr Tyr Arg Glu Asn Thr Gln Arg Trp Gln Asn Ser Leu Arg His Asn 
    50                  55                  60                  


Leu Ser Phe Asn Asp Cys Phe Ile Lys Ile Pro Arg Arg Pro Asp Gln 
65                  70                  75                  80  


Pro Gly Lys Gly Ser Phe Trp Ala Leu His Pro Ser Cys Gly Asp Met 
                85                  90                  95      


Phe Glu Asn Gly Ser Phe Leu Arg Arg Arg Lys Arg Phe Lys Val Leu 
            100                 105                 110         


Lys Ser Asp His Leu Ala Pro Ser Lys Pro Ala Asp Ala Ala Gln Tyr 
        115                 120                 125             


Leu Gln Gln Gln Ala Lys Leu Arg Leu Ser Ala Leu Ala Ala Ser Gly 
    130                 135                 140                 


Thr His Leu Pro Gln Met Pro Ala Ala Ala Tyr Asn Leu Gly Gly Val 
145                 150                 155                 160 


Ala Gln Pro Ser Gly Phe Lys His Pro Phe Ala Ile Glu Asn Ile Ile 
                165                 170                 175     


Ala Arg Glu Tyr Lys Met Pro Gly Gly Leu Ala Phe Ser Ala Met Gln 
            180                 185                 190         


Pro Val Pro Ala Ala Tyr Pro Leu Pro Asn Gln Leu Thr Thr Met Gly 
        195                 200                 205             


Ser Ser Leu Gly Thr Gly Trp Pro His Val Tyr Gly Ser Ala Gly Met 
    210                 215                 220                 


Ile Asp Ser Ala Thr Pro Ile Ser Met Ala Ser Gly Asp Tyr Ser Ala 
225                 230                 235                 240 


Tyr Gly Val Pro Leu Lys Pro Leu Cys His Ala Ala Gly Gln Thr Leu 
                245                 250                 255     


Pro Ala Ile Pro Val Pro Ile Lys Pro Thr Pro Ala Ala Val Pro Ala 
            260                 265                 270         


Leu Pro Ala Leu Pro Ala Pro Ile Pro Thr Leu Leu Ser Asn Ser Pro 
        275                 280                 285             


Pro Ser Leu Ser Pro Thr Ser Ser Gln Thr Ala Thr Ser Gln Ser Ser 
    290                 295                 300                 


Pro Ala Thr Pro Ser Glu Thr Leu Thr Ser Pro Ala Ser Ala Leu His 
305                 310                 315                 320 


Ser Val Ala Val His 
                325 


<210>  4137
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXC1__Homo_sapiens__NP_001444

<400>  4137

Met Gln Ala Arg Tyr Ser Val Ser Ser Pro Asn Ser Leu Gly Val Val 
1               5                   10                  15      


Pro Tyr Leu Gly Gly Glu Gln Ser Tyr Tyr Arg Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Gly Gly Gly Tyr Thr Ala Met Pro Ala Pro Met Ser Val Tyr Ser 
        35                  40                  45              


His Pro Ala His Ala Glu Gln Tyr Pro Gly Gly Met Ala Arg Ala Tyr 
    50                  55                  60                  


Gly Pro Tyr Thr Pro Gln Pro Gln Pro Lys Asp Met Val Lys Pro Pro 
65                  70                  75                  80  


Tyr Ser Tyr Ile Ala Leu Ile Thr Met Ala Ile Gln Asn Ala Pro Asp 
                85                  90                  95      


Lys Lys Ile Thr Leu Asn Gly Ile Tyr Gln Phe Ile Met Asp Arg Phe 
            100                 105                 110         


Pro Phe Tyr Arg Asp Asn Lys Gln Gly Trp Gln Asn Ser Ile Arg His 
        115                 120                 125             


Asn Leu Ser Leu Asn Glu Cys Phe Val Lys Val Pro Arg Asp Asp Lys 
    130                 135                 140                 


Lys Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro Asp Ser Tyr Asn 
145                 150                 155                 160 


Met Phe Glu Asn Gly Ser Phe Leu Arg Arg Arg Arg Arg Phe Lys Lys 
                165                 170                 175     


Lys Asp Ala Val Lys Asp Lys Glu Glu Lys Asp Arg Leu His Leu Lys 
            180                 185                 190         


Glu Pro Pro Pro Pro Gly Arg Gln Pro Pro Pro Ala Pro Pro Glu Gln 
        195                 200                 205             


Ala Asp Gly Asn Ala Pro Gly Pro Gln Pro Pro Pro Val Arg Ile Gln 
    210                 215                 220                 


Asp Ile Lys Thr Glu Asn Gly Thr Cys Pro Ser Pro Pro Gln Pro Leu 
225                 230                 235                 240 


Ser Pro Ala Ala Ala Leu Gly Ser Gly Ser Ala Ala Ala Val Pro Lys 
                245                 250                 255     


Ile Glu Ser Pro Asp Ser Ser Ser Ser Ser Leu Ser Ser Gly Ser Ser 
            260                 265                 270         


Pro Pro Gly Ser Leu Pro Ser Ala Arg Pro Leu Ser Leu Asp Gly Ala 
        275                 280                 285             


Asp Ser Ala Pro Pro Pro Pro Ala Pro Ser Ala Pro Pro Pro His His 
    290                 295                 300                 


Ser Gln Gly Phe Ser Val Asp Asn Ile Met Thr Ser Leu Arg Gly Ser 
305                 310                 315                 320 


Pro Gln Ser Ala Ala Ala Glu Leu Ser Ser Gly Leu Leu Ala Ser Ala 
                325                 330                 335     


Ala Ala Ser Ser Arg Ala Gly Ile Ala Pro Pro Leu Ala Leu Gly Ala 
            340                 345                 350         


Tyr Ser Pro Gly Gln Ser Ser Leu Tyr Ser Ser Pro Cys Ser Gln Thr 
        355                 360                 365             


Ser Ser Ala Gly Ser Ser Gly Gly Gly Gly Gly Gly Ala Gly Ala Ala 
    370                 375                 380                 


Gly Gly Ala Gly Gly Ala Gly Thr Tyr His Cys Asn Leu Gln Ala Met 
385                 390                 395                 400 


Ser Leu Tyr Ala Ala Gly Glu Arg Gly Gly His Leu Gln Gly Ala Pro 
                405                 410                 415     


Gly Gly Ala Gly Gly Ser Ala Val Asp Asp Pro Leu Pro Asp Tyr Ser 
            420                 425                 430         


Leu Pro Pro Val Thr Ser Ser Ser Ser Ser Ser Leu Ser His Gly Gly 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gln Glu Ala Gly His His Pro Ala 
    450                 455                 460                 


Ala His Gln Gly Arg Leu Thr Ser Trp Tyr Leu Asn Gln Ala Gly Gly 
465                 470                 475                 480 


Asp Leu Gly His Leu Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly 
                485                 490                 495     


Tyr Pro Gly Gln Gln Gln Asn Phe His Ser Val Arg Glu Met Phe Glu 
            500                 505                 510         


Ser Gln Arg Ile Gly Leu Asn Asn Ser Pro Val Asn Gly Asn Ser Ser 
        515                 520                 525             


Cys Gln Met Ala Phe Pro Ser Ser Gln Ser Leu Tyr Arg Thr Ser Gly 
    530                 535                 540                 


Ala Phe Val Tyr Asp Cys Ser Lys Phe 
545                 550             


<210>  4138
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXC2__Homo_sapiens__NP_005242

<400>  4138

Met Gln Ala Arg Tyr Ser Val Ser Asp Pro Asn Ala Leu Gly Val Val 
1               5                   10                  15      


Pro Tyr Leu Ser Glu Gln Asn Tyr Tyr Arg Ala Ala Gly Ser Tyr Gly 
            20                  25                  30          


Gly Met Ala Ser Pro Met Gly Val Tyr Ser Gly His Pro Glu Gln Tyr 
        35                  40                  45              


Ser Ala Gly Met Gly Arg Ser Tyr Ala Pro Tyr His His His Gln Pro 
    50                  55                  60                  


Ala Ala Pro Lys Asp Leu Val Lys Pro Pro Tyr Ser Tyr Ile Ala Leu 
65                  70                  75                  80  


Ile Thr Met Ala Ile Gln Asn Ala Pro Glu Lys Lys Ile Thr Leu Asn 
                85                  90                  95      


Gly Ile Tyr Gln Phe Ile Met Asp Arg Phe Pro Phe Tyr Arg Glu Asn 
            100                 105                 110         


Lys Gln Gly Trp Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn Glu 
        115                 120                 125             


Cys Phe Val Lys Val Pro Arg Asp Asp Lys Lys Pro Gly Lys Gly Ser 
    130                 135                 140                 


Tyr Trp Thr Leu Asp Pro Asp Ser Tyr Asn Met Phe Glu Asn Gly Ser 
145                 150                 155                 160 


Phe Leu Arg Arg Arg Arg Arg Phe Lys Lys Lys Asp Val Ser Lys Glu 
                165                 170                 175     


Lys Glu Glu Arg Ala His Leu Lys Glu Pro Pro Pro Ala Ala Ser Lys 
            180                 185                 190         


Gly Ala Pro Ala Thr Pro His Leu Ala Asp Ala Pro Lys Glu Ala Glu 
        195                 200                 205             


Lys Lys Val Val Ile Lys Ser Glu Ala Ala Ser Pro Ala Leu Pro Val 
    210                 215                 220                 


Ile Thr Lys Val Glu Thr Leu Ser Pro Glu Ser Ala Leu Gln Gly Ser 
225                 230                 235                 240 


Pro Arg Ser Ala Ala Ser Thr Pro Ala Gly Ser Pro Asp Gly Ser Leu 
                245                 250                 255     


Pro Glu His His Ala Ala Ala Pro Asn Gly Leu Pro Gly Phe Ser Val 
            260                 265                 270         


Glu Asn Ile Met Thr Leu Arg Thr Ser Pro Pro Gly Gly Glu Leu Ser 
        275                 280                 285             


Pro Gly Ala Gly Arg Ala Gly Leu Val Val Pro Pro Leu Ala Leu Pro 
    290                 295                 300                 


Tyr Ala Ala Ala Pro Pro Ala Ala Tyr Gly Gln Pro Cys Ala Gln Gly 
305                 310                 315                 320 


Leu Glu Ala Gly Ala Ala Gly Gly Tyr Gln Cys Ser Met Arg Ala Met 
                325                 330                 335     


Ser Leu Tyr Thr Gly Ala Glu Arg Pro Ala His Met Cys Val Pro Pro 
            340                 345                 350         


Ala Leu Asp Glu Ala Leu Ser Asp His Pro Ser Gly Pro Thr Ser Pro 
        355                 360                 365             


Leu Ser Ala Leu Asn Leu Ala Ala Gly Gln Glu Gly Ala Leu Ala Ala 
    370                 375                 380                 


Thr Gly His His His Gln His His Gly His His His Pro Gln Ala Pro 
385                 390                 395                 400 


Pro Pro Pro Pro Ala Pro Gln Pro Gln Pro Thr Pro Gln Pro Gly Ala 
                405                 410                 415     


Ala Ala Ala Gln Ala Ala Ser Trp Tyr Leu Asn His Ser Gly Asp Leu 
            420                 425                 430         


Asn His Leu Pro Gly His Thr Phe Ala Ala Gln Gln Gln Thr Phe Pro 
        435                 440                 445             


Asn Val Arg Glu Met Phe Asn Ser His Arg Leu Gly Ile Glu Asn Ser 
    450                 455                 460                 


Thr Leu Gly Glu Ser Gln Val Ser Gly Asn Ala Ser Cys Gln Leu Pro 
465                 470                 475                 480 


Tyr Arg Ser Thr Pro Pro Leu Tyr Arg His Ala Ala Pro Tyr Ser Tyr 
                485                 490                 495     


Asp Cys Thr Lys Tyr 
            500     


<210>  4139
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXD1__Homo_sapiens__NP_004463

<400>  4139

Met Thr Leu Ser Thr Glu Met Ser Asp Ala Ser Gly Leu Ala Glu Glu 
1               5                   10                  15      


Thr Asp Ile Asp Val Val Gly Glu Gly Glu Asp Glu Glu Asp Glu Glu 
            20                  25                  30          


Glu Glu Asp Asp Asp Glu Gly Gly Gly Gly Gly Pro Arg Leu Ala Val 
        35                  40                  45              


Pro Ala Gln Arg Arg Arg Arg Arg Arg Ser Tyr Ala Gly Glu Asp Glu 
    50                  55                  60                  


Leu Glu Asp Leu Glu Glu Glu Glu Asp Asp Asp Asp Ile Leu Leu Ala 
65                  70                  75                  80  


Pro Pro Ala Gly Gly Ser Pro Ala Pro Pro Gly Pro Ala Pro Ala Ala 
                85                  90                  95      


Gly Ala Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Ala Gly Ser Gly Ala Lys Asn Pro Leu Val Lys Pro Pro Tyr 
        115                 120                 125             


Ser Tyr Ile Ala Leu Ile Thr Met Ala Ile Leu Gln Ser Pro Lys Lys 
    130                 135                 140                 


Arg Leu Thr Leu Ser Glu Ile Cys Glu Phe Ile Ser Gly Arg Phe Pro 
145                 150                 155                 160 


Tyr Tyr Arg Glu Lys Phe Pro Ala Trp Gln Asn Ser Ile Arg His Asn 
                165                 170                 175     


Leu Ser Leu Asn Asp Cys Phe Val Lys Ile Pro Arg Glu Pro Gly Asn 
            180                 185                 190         


Pro Gly Lys Gly Asn Tyr Trp Thr Leu Asp Pro Glu Ser Ala Asp Met 
        195                 200                 205             


Phe Asp Asn Gly Ser Phe Leu Arg Arg Arg Lys Arg Phe Lys Arg Gln 
    210                 215                 220                 


Pro Leu Leu Pro Pro Asn Ala Ala Ala Ala Glu Ser Leu Leu Leu Arg 
225                 230                 235                 240 


Gly Ala Gly Ala Ala Gly Gly Ala Gly Asp Pro Ala Ala Ala Ala Ala 
                245                 250                 255     


Leu Phe Pro Pro Ala Pro Pro Pro Pro Pro His Ala Tyr Gly Tyr Gly 
            260                 265                 270         


Pro Tyr Gly Cys Gly Tyr Gly Leu Gln Leu Pro Pro Tyr Ala Pro Pro 
        275                 280                 285             


Ser Ala Leu Phe Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe 
    290                 295                 300                 


His Pro His Ser Pro Pro Pro Pro Pro Pro Pro His Gly Ala Ala Ala 
305                 310                 315                 320 


Glu Leu Ala Arg Thr Ala Phe Gly Tyr Arg Pro His Pro Leu Gly Ala 
                325                 330                 335     


Ala Leu Pro Gly Pro Leu Pro Ala Ser Ala Ala Lys Ala Gly Gly Pro 
            340                 345                 350         


Gly Ala Ser Ala Leu Ala Arg Ser Pro Phe Ser Ile Glu Ser Ile Ile 
        355                 360                 365             


Gly Gly Ser Leu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Gln Ala 
    370                 375                 380                 


Ala Ala Ala Ala Gln Ala Ser Pro Ser Pro Ser Pro Val Ala Ala Pro 
385                 390                 395                 400 


Pro Ala Pro Gly Ser Ser Gly Gly Gly Cys Ala Ala Gln Ala Ala Val 
                405                 410                 415     


Gly Pro Ala Ala Ala Leu Thr Arg Ser Leu Val Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Ala Ser Ser Val Ser Ser Ser Ala Ala Leu Gly Thr Leu His Gln 
        435                 440                 445             


Gly Thr Ala Leu Ser Ser Val Glu Asn Phe Thr Ala Arg Ile Ser Asn 
    450                 455                 460                 


Cys 
465 


<210>  4140
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXE1__Homo_sapiens__NP_004464

<400>  4140

Met Thr Ala Glu Ser Gly Pro Pro Pro Pro Gln Pro Glu Val Leu Ala 
1               5                   10                  15      


Thr Val Lys Glu Glu Arg Gly Glu Thr Ala Ala Gly Ala Gly Val Pro 
            20                  25                  30          


Gly Glu Ala Thr Gly Arg Gly Ala Gly Gly Arg Arg Arg Lys Arg Pro 
        35                  40                  45              


Leu Gln Arg Gly Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Ala Met 
    50                  55                  60                  


Ala Ile Ala His Ala Pro Glu Arg Arg Leu Thr Leu Gly Gly Ile Tyr 
65                  70                  75                  80  


Lys Phe Ile Thr Glu Arg Phe Pro Phe Tyr Arg Asp Asn Pro Lys Lys 
                85                  90                  95      


Trp Gln Asn Ser Ile Arg His Asn Leu Thr Leu Asn Asp Cys Phe Leu 
            100                 105                 110         


Lys Ile Pro Arg Glu Ala Gly Arg Pro Gly Lys Gly Asn Tyr Trp Ala 
        115                 120                 125             


Leu Asp Pro Asn Ala Glu Asp Met Phe Glu Ser Gly Ser Phe Leu Arg 
    130                 135                 140                 


Arg Arg Lys Arg Phe Lys Arg Ser Asp Leu Ser Thr Tyr Pro Ala Tyr 
145                 150                 155                 160 


Met His Asp Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ile Phe Pro Gly Ala Val Pro Ala Ala Arg Pro Pro Tyr 
            180                 185                 190         


Pro Gly Ala Val Tyr Ala Gly Tyr Ala Pro Pro Ser Leu Ala Ala Pro 
        195                 200                 205             


Pro Pro Val Tyr Tyr Pro Ala Ala Ser Pro Gly Pro Cys Arg Val Phe 
    210                 215                 220                 


Gly Leu Val Pro Glu Arg Pro Leu Ser Pro Glu Leu Gly Pro Ala Pro 
225                 230                 235                 240 


Ser Gly Pro Gly Gly Ser Cys Ala Phe Ala Ser Ala Gly Ala Pro Ala 
                245                 250                 255     


Thr Thr Thr Gly Tyr Gln Pro Ala Gly Cys Thr Gly Ala Arg Pro Ala 
            260                 265                 270         


Asn Pro Ser Ala Tyr Ala Ala Ala Tyr Ala Gly Pro Asp Gly Ala Tyr 
        275                 280                 285             


Pro Gln Gly Ala Gly Ser Ala Ile Phe Ala Ala Ala Gly Arg Leu Ala 
    290                 295                 300                 


Gly Pro Ala Ser Pro Pro Ala Gly Gly Ser Ser Gly Gly Val Glu Thr 
305                 310                 315                 320 


Thr Val Asp Phe Tyr Gly Arg Thr Ser Pro Gly Gln Phe Gly Ala Leu 
                325                 330                 335     


Gly Ala Cys Tyr Asn Pro Gly Gly Gln Leu Gly Gly Ala Ser Ala Gly 
            340                 345                 350         


Ala Tyr His Ala Arg His Ala Ala Ala Tyr Pro Gly Gly Ile Asp Arg 
        355                 360                 365             


Phe Val Ser Ala Met 
    370             


<210>  4141
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXF1__Homo_sapiens__NP_001442

<400>  4141

Met Ser Ser Ala Pro Glu Lys Gln Gln Pro Pro His Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Ala Ala Met Asp Pro Ala Ser Ser Gly 
            20                  25                  30          


Pro Ser Lys Ala Lys Lys Thr Asn Ala Gly Ile Arg Arg Pro Glu Lys 
        35                  40                  45              


Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Val Met Ala Ile Gln Ser Ser 
    50                  55                  60                  


Pro Thr Lys Arg Leu Thr Leu Ser Glu Ile Tyr Gln Phe Leu Gln Ser 
65                  70                  75                  80  


Arg Phe Pro Phe Phe Arg Gly Ser Tyr Gln Gly Trp Lys Asn Ser Val 
                85                  90                  95      


Arg His Asn Leu Ser Leu Asn Glu Cys Phe Ile Lys Leu Pro Lys Gly 
            100                 105                 110         


Leu Gly Arg Pro Gly Lys Gly His Tyr Trp Thr Ile Asp Pro Ala Ser 
        115                 120                 125             


Glu Phe Met Phe Glu Glu Gly Ser Phe Arg Arg Arg Pro Arg Gly Phe 
    130                 135                 140                 


Arg Arg Lys Cys Gln Ala Leu Lys Pro Met Tyr Ser Met Met Asn Gly 
145                 150                 155                 160 


Leu Gly Phe Asn His Leu Pro Asp Thr Tyr Gly Phe Gln Gly Ser Ala 
                165                 170                 175     


Gly Gly Leu Ser Cys Pro Pro Asn Ser Leu Ala Leu Glu Gly Gly Leu 
            180                 185                 190         


Gly Met Met Asn Gly His Leu Pro Gly Asn Val Asp Gly Met Ala Leu 
        195                 200                 205             


Pro Ser His Ser Val Pro His Leu Pro Ser Asn Gly Gly His Ser Tyr 
    210                 215                 220                 


Met Gly Gly Cys Gly Gly Ala Ala Ala Gly Glu Tyr Pro His His Asp 
225                 230                 235                 240 


Ser Ser Val Pro Ala Ser Pro Leu Leu Pro Thr Gly Ala Gly Gly Val 
                245                 250                 255     


Met Glu Pro His Ala Val Tyr Ser Gly Ser Ala Ala Ala Trp Pro Pro 
            260                 265                 270         


Ser Ala Ser Ala Ala Leu Asn Ser Gly Ala Ser Tyr Ile Lys Gln Gln 
        275                 280                 285             


Pro Leu Ser Pro Cys Asn Pro Ala Ala Asn Pro Leu Ser Gly Ser Leu 
    290                 295                 300                 


Ser Thr His Ser Leu Glu Gln Pro Tyr Leu His Gln Asn Ser His Asn 
305                 310                 315                 320 


Ala Pro Ala Glu Leu Gln Gly Ile Pro Arg Tyr His Ser Gln Ser Pro 
                325                 330                 335     


Ser Met Cys Asp Arg Lys Glu Phe Val Phe Ser Phe Asn Ala Met Ala 
            340                 345                 350         


Ser Ser Ser Met His Ser Ala Gly Gly Gly Ser Tyr Tyr His Gln Gln 
        355                 360                 365             


Val Thr Tyr Gln Asp Ile Lys Pro Cys Val Met 
    370                 375                 


<210>  4142
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXF2__Homo_sapiens__NP_001443

<400>  4142

Met Thr Thr Glu Gly Gly Pro Pro Pro Ala Pro Leu Arg Arg Ala Cys 
1               5                   10                  15      


Ser Pro Val Pro Gly Ala Leu Gln Ala Ala Leu Met Ser Pro Pro Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Pro Glu Thr Thr Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ala Ser Cys Ala Ser Ser Ser Ser Ser Ser Asn 
    50                  55                  60                  


Ser Ala Ser Ala Pro Ser Ala Ala Cys Lys Ser Ala Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Ala Gly Ser Gly Gly Ala Lys Lys Ala Ser Ser Gly Leu Arg 
                85                  90                  95      


Arg Pro Glu Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Val Met Ala 
            100                 105                 110         


Ile Gln Ser Ser Pro Ser Lys Arg Leu Thr Leu Ser Glu Ile Tyr Gln 
        115                 120                 125             


Phe Leu Gln Ala Arg Phe Pro Phe Phe Arg Gly Ala Tyr Gln Gly Trp 
    130                 135                 140                 


Lys Asn Ser Val Arg His Asn Leu Ser Leu Asn Glu Cys Phe Ile Lys 
145                 150                 155                 160 


Leu Pro Lys Gly Leu Gly Arg Pro Gly Lys Gly His Tyr Trp Thr Ile 
                165                 170                 175     


Asp Pro Ala Ser Glu Phe Met Phe Glu Glu Gly Ser Phe Arg Arg Arg 
            180                 185                 190         


Pro Arg Gly Phe Arg Arg Lys Cys Gln Ala Leu Lys Pro Met Tyr His 
        195                 200                 205             


Arg Val Val Ser Gly Leu Gly Phe Gly Ala Ser Leu Leu Pro Gln Gly 
    210                 215                 220                 


Phe Asp Phe Gln Ala Pro Pro Ser Ala Pro Leu Gly Cys His Ser Gln 
225                 230                 235                 240 


Gly Gly Tyr Gly Gly Leu Asp Met Met Pro Ala Gly Tyr Asp Ala Gly 
                245                 250                 255     


Ala Gly Ala Pro Ser His Ala His Pro His His His His His His His 
            260                 265                 270         


Val Pro His Met Ser Pro Asn Pro Gly Ser Thr Tyr Met Ala Ser Cys 
        275                 280                 285             


Pro Val Pro Ala Gly Pro Gly Gly Val Gly Ala Ala Gly Gly Gly Gly 
    290                 295                 300                 


Gly Gly Asp Tyr Gly Pro Asp Ser Ser Ser Ser Pro Val Pro Ser Ser 
305                 310                 315                 320 


Pro Ala Met Ala Ser Ala Ile Glu Cys His Ser Pro Tyr Thr Ser Pro 
                325                 330                 335     


Ala Ala His Trp Ser Ser Pro Gly Ala Ser Pro Tyr Leu Lys Gln Pro 
            340                 345                 350         


Pro Ala Leu Thr Pro Ser Ser Asn Pro Ala Ala Ser Ala Gly Leu His 
        355                 360                 365             


Ser Ser Met Ser Ser Tyr Ser Leu Glu Gln Ser Tyr Leu His Gln Asn 
    370                 375                 380                 


Ala Arg Glu Asp Leu Ser Val Gly Leu Pro Arg Tyr Gln His His Ser 
385                 390                 395                 400 


Thr Pro Val Cys Asp Arg Lys Asp Phe Val Leu Asn Phe Asn Gly Ile 
                405                 410                 415     


Ser Ser Phe His Pro Ser Ala Ser Gly Ser Tyr Tyr His His His His 
            420                 425                 430         


Gln Ser Val Cys Gln Asp Ile Lys Pro Cys Val Met 
        435                 440                 


<210>  4143
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXG1__Homo_sapiens__NP_005240

<400>  4143

Met Leu Asp Met Gly Asp Arg Lys Glu Val Lys Met Ile Pro Lys Ser 
1               5                   10                  15      


Ser Phe Ser Ile Asn Ser Leu Val Pro Glu Ala Val Gln Asn Asp Asn 
            20                  25                  30          


His His Ala Ser His Gly His His Asn Ser His His Pro Gln His His 
        35                  40                  45              


His His His His His His His His His Pro Pro Pro Pro Ala Pro Gln 
    50                  55                  60                  


Pro Pro Pro Pro Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Ala Pro Gln Pro Pro Gln Thr Arg Gly Ala Pro Ala Ala Asp Asp Asp 
                85                  90                  95      


Lys Gly Pro Gln Gln Leu Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro 
            100                 105                 110         


Ala Ala Ala Leu Asp Gly Ala Lys Ala Asp Gly Leu Gly Gly Lys Gly 
        115                 120                 125             


Glu Pro Gly Gly Gly Pro Gly Glu Leu Ala Pro Val Gly Pro Asp Glu 
    130                 135                 140                 


Lys Glu Lys Gly Ala Gly Ala Gly Gly Glu Glu Lys Lys Gly Ala Gly 
145                 150                 155                 160 


Glu Gly Gly Lys Asp Gly Glu Gly Gly Lys Glu Gly Glu Lys Lys Asn 
                165                 170                 175     


Gly Lys Tyr Glu Lys Pro Pro Phe Ser Tyr Asn Ala Leu Ile Met Met 
            180                 185                 190         


Ala Ile Arg Gln Ser Pro Glu Lys Arg Leu Thr Leu Asn Gly Ile Tyr 
        195                 200                 205             


Glu Phe Ile Met Lys Asn Phe Pro Tyr Tyr Arg Glu Asn Lys Gln Gly 
    210                 215                 220                 


Trp Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn Lys Cys Phe Val 
225                 230                 235                 240 


Lys Val Pro Arg His Tyr Asp Asp Pro Gly Lys Gly Asn Tyr Trp Met 
                245                 250                 255     


Leu Asp Pro Ser Ser Asp Asp Val Phe Ile Gly Gly Thr Thr Gly Lys 
            260                 265                 270         


Leu Arg Arg Arg Ser Thr Thr Ser Arg Ala Lys Leu Ala Phe Lys Arg 
        275                 280                 285             


Gly Ala Arg Leu Thr Ser Thr Gly Leu Thr Phe Met Asp Arg Ala Gly 
    290                 295                 300                 


Ser Leu Tyr Trp Pro Met Ser Pro Phe Leu Ser Leu His His Pro Arg 
305                 310                 315                 320 


Ala Ser Ser Thr Leu Ser Tyr Asn Gly Thr Thr Ser Ala Tyr Pro Ser 
                325                 330                 335     


His Pro Met Pro Tyr Ser Ser Val Leu Thr Gln Asn Ser Leu Gly Asn 
            340                 345                 350         


Asn His Ser Phe Ser Thr Ala Asn Gly Leu Ser Val Asp Arg Leu Val 
        355                 360                 365             


Asn Gly Glu Ile Pro Tyr Ala Thr His His Leu Thr Ala Ala Ala Leu 
    370                 375                 380                 


Ala Ala Ser Val Pro Cys Gly Leu Ser Val Pro Cys Ser Gly Thr Tyr 
385                 390                 395                 400 


Ser Leu Asn Pro Cys Ser Val Asn Leu Leu Ala Gly Gln Thr Ser Tyr 
                405                 410                 415     


Phe Phe Pro His Val Pro His Pro Ser Met Thr Ser Gln Ser Ser Thr 
            420                 425                 430         


Ser Met Ser Ala Arg Ala Ala Ser Ser Ser Thr Ser Pro Gln Ala Pro 
        435                 440                 445             


Ser Thr Leu Pro Cys Glu Ser Leu Arg Pro Ser Leu Pro Ser Phe Thr 
    450                 455                 460                 


Thr Gly Leu Ser Gly Gly Leu Ser Asp Tyr Phe Thr His Gln Asn Gln 
465                 470                 475                 480 


Gly Ser Ser Ser Asn Pro Leu Ile His 
                485                 


<210>  4144
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXH1__Homo_sapiens__NP_003914

<400>  4144

Met Gly Pro Cys Ser Gly Ser Arg Leu Gly Pro Pro Glu Ala Glu Ser 
1               5                   10                  15      


Pro Ser Gln Pro Pro Lys Arg Arg Lys Lys Arg Tyr Leu Arg His Asp 
            20                  25                  30          


Lys Pro Pro Tyr Thr Tyr Leu Ala Met Ile Ala Leu Val Ile Gln Ala 
        35                  40                  45              


Ala Pro Ser Arg Arg Leu Lys Leu Ala Gln Ile Ile Arg Gln Val Gln 
    50                  55                  60                  


Ala Val Phe Pro Phe Phe Arg Glu Asp Tyr Glu Gly Trp Lys Asp Ser 
65                  70                  75                  80  


Ile Arg His Asn Leu Ser Ser Asn Arg Cys Phe Arg Lys Val Pro Lys 
                85                  90                  95      


Asp Pro Ala Lys Pro Gln Ala Lys Gly Asn Phe Trp Ala Val Asp Val 
            100                 105                 110         


Ser Leu Ile Pro Ala Glu Ala Leu Arg Leu Gln Asn Thr Ala Leu Cys 
        115                 120                 125             


Arg Arg Trp Gln Asn Gly Gly Ala Arg Gly Ala Phe Ala Lys Asp Leu 
    130                 135                 140                 


Gly Pro Tyr Val Leu His Gly Arg Pro Tyr Arg Pro Pro Ser Pro Pro 
145                 150                 155                 160 


Pro Pro Pro Ser Glu Gly Phe Ser Ile Lys Ser Leu Leu Gly Gly Ser 
                165                 170                 175     


Gly Glu Gly Ala Pro Trp Pro Gly Leu Ala Pro Gln Ser Ser Pro Val 
            180                 185                 190         


Pro Ala Gly Thr Gly Asn Ser Gly Glu Glu Ala Val Pro Thr Pro Pro 
        195                 200                 205             


Leu Pro Ser Ser Glu Arg Pro Leu Trp Pro Leu Cys Pro Leu Pro Gly 
    210                 215                 220                 


Pro Thr Arg Val Glu Gly Glu Thr Val Gln Gly Gly Ala Ile Gly Pro 
225                 230                 235                 240 


Ser Thr Leu Ser Pro Glu Pro Arg Ala Trp Pro Leu His Leu Leu Gln 
                245                 250                 255     


Gly Thr Ala Val Pro Gly Gly Arg Ser Ser Gly Gly His Arg Ala Ser 
            260                 265                 270         


Leu Trp Gly Gln Leu Pro Thr Ser Tyr Leu Pro Ile Tyr Thr Pro Asn 
        275                 280                 285             


Val Val Met Pro Leu Ala Pro Pro Pro Thr Ser Cys Pro Gln Cys Pro 
    290                 295                 300                 


Ser Thr Ser Pro Ala Tyr Trp Gly Val Ala Pro Glu Thr Arg Gly Pro 
305                 310                 315                 320 


Pro Gly Leu Leu Cys Asp Leu Asp Ala Leu Phe Gln Gly Val Pro Pro 
                325                 330                 335     


Asn Lys Ser Ile Tyr Asp Val Trp Val Ser His Pro Arg Asp Leu Ala 
            340                 345                 350         


Ala Pro Gly Pro Gly Trp Leu Leu Ser Trp Cys Ser Leu 
        355                 360                 365 


<210>  4145
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXI1__Homo_sapiens__NP_036320

<400>  4145

Met Ser Ser Phe Asp Leu Pro Ala Pro Ser Pro Pro Arg Cys Ser Pro 
1               5                   10                  15      


Gln Phe Pro Ser Ile Gly Gln Glu Pro Pro Glu Met Asn Leu Tyr Tyr 
            20                  25                  30          


Glu Asn Phe Phe His Pro Gln Gly Val Pro Ser Pro Gln Arg Pro Ser 
        35                  40                  45              


Phe Glu Gly Gly Gly Glu Tyr Gly Ala Thr Pro Asn Pro Tyr Leu Trp 
    50                  55                  60                  


Phe Asn Gly Pro Thr Met Thr Pro Pro Pro Tyr Leu Pro Gly Pro Asn 
65                  70                  75                  80  


Ala Ser Pro Phe Leu Pro Gln Ala Tyr Gly Val Gln Arg Pro Leu Leu 
                85                  90                  95      


Pro Ser Val Ser Gly Leu Gly Gly Ser Asp Leu Gly Trp Leu Pro Ile 
            100                 105                 110         


Pro Ser Gln Glu Glu Leu Met Lys Leu Val Arg Pro Pro Tyr Ser Tyr 
        115                 120                 125             


Ser Ala Leu Ile Ala Met Ala Ile His Gly Ala Pro Asp Lys Arg Leu 
    130                 135                 140                 


Thr Leu Ser Gln Ile Tyr Gln Tyr Val Ala Asp Asn Phe Pro Phe Tyr 
145                 150                 155                 160 


Asn Lys Ser Lys Ala Gly Trp Gln Asn Ser Ile Arg His Asn Leu Ser 
                165                 170                 175     


Leu Asn Asp Cys Phe Lys Lys Val Pro Arg Asp Glu Asp Asp Pro Gly 
            180                 185                 190         


Lys Gly Asn Tyr Trp Thr Leu Asp Pro Asn Cys Glu Lys Met Phe Asp 
        195                 200                 205             


Asn Gly Asn Phe Arg Arg Lys Arg Lys Arg Lys Ser Asp Val Ser Ser 
    210                 215                 220                 


Ser Thr Ala Ser Leu Ala Leu Glu Lys Thr Glu Ser Ser Leu Pro Val 
225                 230                 235                 240 


Asp Ser Pro Lys Thr Thr Glu Pro Gln Asp Ile Leu Asp Gly Ala Ser 
                245                 250                 255     


Pro Gly Gly Thr Thr Ser Ser Pro Glu Lys Arg Pro Ser Pro Pro Pro 
            260                 265                 270         


Ser Gly Ala Pro Cys Leu Asn Ser Phe Leu Ser Ser Met Thr Ala Tyr 
        275                 280                 285             


Val Ser Gly Gly Ser Pro Thr Ser His Pro Leu Val Thr Pro Gly Leu 
    290                 295                 300                 


Ser Pro Glu Pro Ser Asp Lys Thr Gly Gln Asn Ser Leu Thr Phe Asn 
305                 310                 315                 320 


Ser Phe Ser Pro Leu Thr Asn Leu Ser Asn His Ser Gly Gly Gly Asp 
                325                 330                 335     


Trp Ala Asn Pro Met Pro Thr Asn Met Leu Ser Tyr Gly Gly Ser Val 
            340                 345                 350         


Leu Ser Gln Phe Ser Pro His Phe Tyr Asn Ser Val Asn Thr Ser Gly 
        355                 360                 365             


Val Leu Tyr Pro Arg Glu Gly Thr Glu Val 
    370                 375             


<210>  4146
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXJ1__Homo_sapiens__NP_001445

<400>  4146

Met Ala Glu Ser Trp Leu Arg Leu Ser Gly Ala Gly Pro Ala Glu Glu 
1               5                   10                  15      


Ala Gly Pro Glu Gly Gly Leu Glu Glu Pro Asp Ala Leu Asp Asp Ser 
            20                  25                  30          


Leu Thr Ser Leu Gln Trp Leu Gln Glu Phe Ser Ile Leu Asn Ala Lys 
        35                  40                  45              


Ala Pro Ala Leu Pro Pro Gly Gly Thr Asp Pro His Gly Tyr His Gln 
    50                  55                  60                  


Val Pro Gly Ser Ala Ala Pro Gly Ser Pro Leu Ala Ala Asp Pro Ala 
65                  70                  75                  80  


Cys Leu Gly Gln Pro His Thr Pro Gly Lys Pro Thr Ser Ser Cys Thr 
                85                  90                  95      


Ser Arg Ser Ala Pro Pro Gly Leu Gln Ala Pro Pro Pro Asp Asp Val 
            100                 105                 110         


Asp Tyr Ala Thr Asn Pro His Val Lys Pro Pro Tyr Ser Tyr Ala Thr 
        115                 120                 125             


Leu Ile Cys Met Ala Met Gln Ala Ser Lys Ala Thr Lys Ile Thr Leu 
    130                 135                 140                 


Ser Ala Ile Tyr Lys Trp Ile Thr Asp Asn Phe Cys Tyr Phe Arg His 
145                 150                 155                 160 


Ala Asp Pro Thr Trp Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn 
                165                 170                 175     


Lys Cys Phe Ile Lys Val Pro Arg Glu Lys Asp Glu Pro Gly Lys Gly 
            180                 185                 190         


Gly Phe Trp Arg Ile Asp Pro Gln Tyr Ala Glu Arg Leu Leu Ser Gly 
        195                 200                 205             


Ala Phe Lys Lys Arg Arg Leu Pro Pro Val His Ile His Pro Ala Phe 
    210                 215                 220                 


Ala Arg Gln Ala Ala Gln Glu Pro Ser Ala Val Pro Arg Ala Gly Pro 
225                 230                 235                 240 


Leu Thr Val Asn Thr Glu Ala Gln Gln Leu Leu Arg Glu Phe Glu Glu 
                245                 250                 255     


Ala Thr Gly Glu Ala Gly Trp Gly Ala Gly Glu Gly Arg Leu Gly His 
            260                 265                 270         


Lys Arg Lys Gln Pro Leu Pro Lys Arg Val Ala Lys Val Pro Arg Pro 
        275                 280                 285             


Pro Ser Thr Leu Leu Pro Thr Pro Glu Glu Gln Gly Glu Leu Glu Pro 
    290                 295                 300                 


Leu Lys Gly Asn Phe Asp Trp Glu Ala Ile Phe Asp Ala Gly Thr Leu 
305                 310                 315                 320 


Gly Gly Glu Leu Gly Ala Leu Glu Ala Leu Glu Leu Ser Pro Pro Leu 
                325                 330                 335     


Ser Pro Ala Ser His Val Asp Val Asp Leu Thr Ile His Gly Arg His 
            340                 345                 350         


Ile Asp Cys Pro Ala Thr Trp Gly Pro Ser Val Glu Gln Ala Ala Asp 
        355                 360                 365             


Ser Leu Asp Phe Asp Glu Thr Phe Leu Ala Thr Ser Phe Leu Gln His 
    370                 375                 380                 


Pro Trp Asp Glu Ser Gly Ser Gly Cys Leu Pro Pro Glu Pro Leu Phe 
385                 390                 395                 400 


Glu Ala Gly Asp Ala Thr Leu Ala Ser Asp Leu Gln Asp Trp Ala Ser 
                405                 410                 415     


Val Gly Ala Phe Leu 
            420     


<210>  4147
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXJ2__Homo_sapiens__NP_060886

<400>  4147

Met Ala Ser Asp Leu Glu Ser Ser Leu Thr Ser Ile Asp Trp Leu Pro 
1               5                   10                  15      


Gln Leu Thr Leu Arg Ala Thr Ile Glu Lys Leu Gly Ser Ala Ser Gln 
            20                  25                  30          


Ala Gly Pro Pro Gly Ser Ser Arg Lys Cys Ser Pro Gly Ser Pro Thr 
        35                  40                  45              


Asp Pro Asn Ala Thr Leu Ser Lys Asp Glu Ala Ala Val His Gln Asp 
    50                  55                  60                  


Gly Lys Pro Arg Tyr Ser Tyr Ala Thr Leu Ile Thr Tyr Ala Ile Asn 
65                  70                  75                  80  


Ser Ser Pro Ala Lys Lys Met Thr Leu Ser Glu Ile Tyr Arg Trp Ile 
                85                  90                  95      


Cys Asp Asn Phe Pro Tyr Tyr Lys Asn Ala Gly Ile Gly Trp Lys Asn 
            100                 105                 110         


Ser Ile Arg His Asn Leu Ser Leu Asn Lys Cys Phe Arg Lys Val Pro 
        115                 120                 125             


Arg Pro Arg Asp Asp Pro Gly Lys Gly Ser Tyr Trp Thr Ile Asp Thr 
    130                 135                 140                 


Cys Pro Asp Ile Ser Arg Lys Arg Arg His Pro Pro Asp Asp Asp Leu 
145                 150                 155                 160 


Ser Gln Asp Ser Pro Glu Gln Glu Ala Ser Lys Ser Pro Arg Gly Gly 
                165                 170                 175     


Val Ala Gly Ser Gly Glu Ala Ser Leu Pro Pro Glu Gly Asn Pro Gln 
            180                 185                 190         


Met Ser Leu Gln Ser Pro Thr Ser Ile Ala Ser Tyr Ser Gln Gly Thr 
        195                 200                 205             


Gly Ser Val Asp Gly Gly Ala Val Ala Ala Gly Ala Ser Gly Arg Glu 
    210                 215                 220                 


Ser Ala Glu Gly Pro Pro Pro Leu Tyr Asn Thr Asn His Asp Phe Lys 
225                 230                 235                 240 


Phe Ser Tyr Ser Glu Ile Asn Phe Gln Asp Leu Ser Trp Ser Phe Arg 
                245                 250                 255     


Asn Leu Tyr Lys Ser Met Leu Glu Lys Ser Ser Ser Ser Ser Gln His 
            260                 265                 270         


Gly Phe Ser Ser Leu Leu Gly Asp Ile Pro Pro Ser Asn Asn Tyr Tyr 
        275                 280                 285             


Met Tyr Gln Gln Gln Gln Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gln Pro Pro Gln Pro Pro Pro Gln Gln Ser Gln Pro Gln Gln Gln 
305                 310                 315                 320 


Gln Ala Pro Ala Gln Gly Pro Ser Ala Val Gly Gly Ala Pro Pro Leu 
                325                 330                 335     


His Thr Pro Ser Thr Asp Gly Cys Thr Pro Pro Gly Gly Lys Gln Ala 
            340                 345                 350         


Gly Ala Glu Gly Tyr Gly Pro Pro Pro Val Met Ala Met His Pro Pro 
        355                 360                 365             


Pro Leu Gln His Gly Gly Tyr His Pro His Gln His His Pro His Ser 
    370                 375                 380                 


His Pro Ala Gln Gln Pro Pro Pro Pro Gln Pro Gln Ala Gln Gly Gln 
385                 390                 395                 400 


Ala Pro Ile Asn Asn Thr Gly Phe Ala Phe Pro Ser Asp Trp Cys Ser 
                405                 410                 415     


Asn Ile Asp Ser Leu Lys Glu Ser Phe Lys Met Val Asn Arg Leu Asn 
            420                 425                 430         


Trp Ser Ser Ile Glu Gln Ser Gln Phe Ser Glu Leu Met Glu Ser Leu 
        435                 440                 445             


Arg Gln Ala Glu Gln Lys Asn Trp Thr Leu Asp Gln His His Ile Ala 
    450                 455                 460                 


Asn Leu Cys Asp Ser Leu Asn His Phe Leu Thr Gln Thr Gly His Val 
465                 470                 475                 480 


Pro Pro Gln Gly Gly Thr His Arg Pro Pro Ala Pro Ala Arg Ile Ala 
                485                 490                 495     


Asp Ser Cys Ala Leu Thr Ser Gly Lys Gln Glu Ser Ala Met Ser Gln 
            500                 505                 510         


Val Asn Ser Tyr Gly His Pro Gln Ala Pro His Leu Tyr Pro Gly Pro 
        515                 520                 525             


Ser Pro Met Tyr Pro Ile Pro Thr Gln Asp Ser Ala Gly Tyr Asn Arg 
    530                 535                 540                 


Pro Ala His His Met Val Pro Arg Pro Ser Val Pro Pro Pro Gly Ala 
545                 550                 555                 560 


Asn Glu Glu Ile Pro Asp Asp Phe Asp Trp Asp Leu Ile Thr 
                565                 570                 


<210>  4148
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXK1__Homo_sapiens__NP_001032242

<400>  4148

Met Ala Glu Val Gly Glu Asp Ser Gly Ala Arg Ala Leu Leu Ala Leu 
1               5                   10                  15      


Arg Ser Ala Pro Cys Ser Pro Val Leu Cys Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Phe Pro Ala Ala Ala Pro Pro Pro Ala Pro Ala Gln Pro Gln Pro 
        35                  40                  45              


Pro Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Ala 
    50                  55                  60                  


Ile Ala Gly Ala Gly Ser Ser Gly Gly Ser Ser Gly Val Ser Gly Asp 
65                  70                  75                  80  


Ser Ala Val Ala Gly Ala Ala Pro Ala Leu Val Ala Ala Ala Ala Ala 
                85                  90                  95      


Ser Val Arg Gln Ser Pro Gly Pro Ala Leu Ala Arg Leu Glu Gly Arg 
            100                 105                 110         


Glu Phe Glu Phe Leu Met Arg Gln Pro Ser Val Thr Ile Gly Arg Asn 
        115                 120                 125             


Ser Ser Gln Gly Ser Val Asp Leu Ser Met Gly Leu Ser Ser Phe Ile 
    130                 135                 140                 


Ser Arg Arg His Leu Gln Leu Ser Phe Gln Glu Pro His Phe Tyr Leu 
145                 150                 155                 160 


Arg Cys Leu Gly Lys Asn Gly Val Phe Val Asp Gly Ala Phe Gln Arg 
                165                 170                 175     


Arg Gly Ala Pro Ala Leu Gln Leu Pro Lys Gln Cys Thr Phe Arg Phe 
            180                 185                 190         


Pro Ser Thr Ala Ile Lys Ile Gln Phe Thr Ser Leu Tyr His Lys Glu 
        195                 200                 205             


Glu Ala Pro Ala Ser Pro Leu Arg Pro Leu Tyr Pro Gln Ile Ser Pro 
    210                 215                 220                 


Leu Lys Ile His Ile Pro Glu Pro Asp Leu Arg Ser Met Val Ser Pro 
225                 230                 235                 240 


Val Pro Ser Pro Thr Gly Thr Ile Ser Val Pro Asn Ser Cys Pro Ala 
                245                 250                 255     


Ser Pro Arg Gly Ala Gly Ser Ser Ser Tyr Arg Phe Val Gln Asn Val 
            260                 265                 270         


Thr Ser Asp Leu Gln Leu Ala Ala Glu Phe Ala Ala Lys Ala Ala Ser 
        275                 280                 285             


Glu Gln Gln Ala Asp Thr Ser Gly Gly Asp Ser Pro Lys Asp Glu Ser 
    290                 295                 300                 


Lys Pro Pro Phe Ser Tyr Ala Gln Leu Ile Val Gln Ala Ile Ser Ser 
305                 310                 315                 320 


Ala Gln Asp Arg Gln Leu Thr Leu Ser Gly Ile Tyr Ala His Ile Thr 
                325                 330                 335     


Lys His Tyr Pro Tyr Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn Ser 
            340                 345                 350         


Ile Arg His Asn Leu Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro Arg 
        355                 360                 365             


Ser Gln Glu Glu Pro Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro Ala 
    370                 375                 380                 


Ser Glu Ala Lys Leu Val Glu Gln Ala Phe Arg Lys Arg Arg Gln Arg 
385                 390                 395                 400 


Gly Val Ser Cys Phe Arg Thr Pro Phe Gly Pro Leu Ser Ser Arg Ser 
                405                 410                 415     


Ala Pro Ala Ser Pro Thr His Pro Gly Leu Met Ser Pro Arg Ser Gly 
            420                 425                 430         


Gly Leu Gln Thr Pro Glu Cys Leu Ser Arg Glu Gly Ser Pro Ile Pro 
        435                 440                 445             


His Asp Pro Glu Phe Gly Ser Lys Leu Ala Ser Val Pro Glu Tyr Arg 
    450                 455                 460                 


Tyr Ser Gln Ser Ala Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile 
465                 470                 475                 480 


Met Ala Val Pro Pro Arg Pro Ser Ser Leu Val Ala Lys Pro Val Ala 
                485                 490                 495     


Tyr Met Pro Ala Ser Ile Val Thr Ser Gln Gln Pro Ala Gly His Ala 
            500                 505                 510         


Ile His Val Val Gln Gln Ala Pro Thr Val Thr Met Val Arg Val Val 
        515                 520                 525             


Thr Thr Ser Ala Asn Ser Ala Asn Gly Tyr Ile Leu Thr Ser Gln Gly 
    530                 535                 540                 


Ala Ala Gly Gly Ser His Asp Ala Ala Gly Ala Ala Val Leu Asp Leu 
545                 550                 555                 560 


Gly Ser Glu Ala Arg Gly Leu Glu Glu Lys Pro Thr Ile Ala Phe Ala 
                565                 570                 575     


Thr Ile Pro Ala Ala Gly Gly Val Ile Gln Thr Val Ala Ser Gln Met 
            580                 585                 590         


Ala Pro Gly Val Pro Gly His Thr Val Thr Ile Leu Gln Pro Ala Thr 
        595                 600                 605             


Pro Val Thr Leu Gly Gln His His Leu Pro Val Arg Ala Val Thr Gln 
    610                 615                 620                 


Asn Gly Lys His Ala Val Pro Thr Asn Ser Leu Ala Gly Asn Ala Tyr 
625                 630                 635                 640 


Ala Leu Thr Ser Pro Leu Gln Leu Leu Ala Thr Gln Ala Ser Ser Ser 
                645                 650                 655     


Ala Pro Val Val Val Thr Arg Val Cys Glu Val Gly Pro Lys Glu Pro 
            660                 665                 670         


Ala Ala Ala Val Ala Ala Thr Ala Thr Thr Thr Pro Ala Thr Ala Thr 
        675                 680                 685             


Thr Ala Ser Ala Ser Ala Ser Ser Thr Gly Glu Pro Glu Val Lys Arg 
    690                 695                 700                 


Ser Arg Val Glu Glu Pro Ser Gly Ala Val Thr Thr Pro Ala Gly Val 
705                 710                 715                 720 


Ile Ala Ala Ala Gly Pro Gln Gly Pro Gly Thr Gly Glu 
                725                 730             


<210>  4149
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXK2__Homo_sapiens__NP_004505

<400>  4149

Met Ala Ala Ala Ala Ala Ala Leu Ser Gly Ala Gly Thr Pro Pro Ala 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser Pro Pro 
            20                  25                  30          


Gly Gly Trp Ala Val Ala Arg Leu Glu Gly Arg Glu Phe Glu Tyr Leu 
        35                  40                  45              


Met Lys Lys Arg Ser Val Thr Ile Gly Arg Asn Ser Ser Gln Gly Ser 
    50                  55                  60                  


Val Asp Val Ser Met Gly His Ser Ser Phe Ile Ser Arg Arg His Leu 
65                  70                  75                  80  


Glu Ile Phe Thr Pro Pro Gly Gly Gly Gly His Gly Gly Ala Ala Pro 
                85                  90                  95      


Glu Leu Pro Pro Ala Gln Pro Arg Pro Asp Ala Gly Gly Asp Phe Tyr 
            100                 105                 110         


Leu Arg Cys Leu Gly Lys Asn Gly Val Phe Val Asp Gly Val Phe Gln 
        115                 120                 125             


Arg Arg Gly Ala Pro Pro Leu Gln Leu Pro Arg Val Cys Thr Phe Arg 
    130                 135                 140                 


Phe Pro Ser Thr Asn Ile Lys Ile Thr Phe Thr Ala Leu Ser Ser Glu 
145                 150                 155                 160 


Lys Arg Glu Lys Gln Glu Ala Ser Glu Ser Pro Val Lys Ala Val Gln 
                165                 170                 175     


Pro His Ile Ser Pro Leu Thr Ile Asn Ile Pro Asp Thr Met Ala His 
            180                 185                 190         


Leu Ile Ser Pro Leu Pro Ser Pro Thr Gly Thr Ile Ser Ala Ala Asn 
        195                 200                 205             


Ser Cys Pro Ser Ser Pro Arg Gly Ala Gly Ser Ser Gly Tyr Lys Val 
    210                 215                 220                 


Gly Arg Val Met Pro Ser Asp Leu Asn Leu Met Ala Asp Asn Ser Gln 
225                 230                 235                 240 


Pro Glu Asn Glu Lys Glu Ala Ser Gly Gly Asp Ser Pro Lys Asp Asp 
                245                 250                 255     


Ser Lys Pro Pro Tyr Ser Tyr Ala Gln Leu Ile Val Gln Ala Ile Thr 
            260                 265                 270         


Met Ala Pro Asp Lys Gln Leu Thr Leu Asn Gly Ile Tyr Thr His Ile 
        275                 280                 285             


Thr Lys Asn Tyr Pro Tyr Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn 
    290                 295                 300                 


Ser Ile Arg His Asn Leu Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro 
305                 310                 315                 320 


Arg Ser Gln Glu Glu Pro Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro 
                325                 330                 335     


Ala Ser Glu Ser Lys Leu Ile Glu Gln Ala Phe Arg Lys Arg Arg Pro 
            340                 345                 350         


Arg Gly Val Pro Cys Phe Arg Thr Pro Leu Gly Pro Leu Ser Ser Arg 
        355                 360                 365             


Ser Ala Pro Ala Ser Pro Asn His Ala Gly Val Leu Ser Ala His Ser 
    370                 375                 380                 


Ser Gly Ala Gln Thr Pro Glu Ser Leu Ser Arg Glu Gly Ser Pro Ala 
385                 390                 395                 400 


Pro Leu Glu Pro Glu Pro Gly Ala Ala Gln Pro Lys Leu Ala Val Ile 
                405                 410                 415     


Gln Glu Ala Arg Phe Ala Gln Ser Ala Pro Gly Ser Pro Leu Ser Ser 
            420                 425                 430         


Gln Pro Val Leu Ile Thr Val Gln Arg Gln Leu Pro Gln Ala Ile Lys 
        435                 440                 445             


Pro Val Thr Tyr Thr Val Ala Thr Pro Val Thr Thr Ser Thr Ser Gln 
    450                 455                 460                 


Pro Pro Val Val Gln Thr Val His Val Val His Gln Ile Pro Ala Val 
465                 470                 475                 480 


Ser Val Thr Ser Val Ala Gly Leu Ala Pro Ala Asn Thr Tyr Thr Val 
                485                 490                 495     


Ser Gly Gln Ala Val Val Thr Pro Ala Ala Val Leu Ala Pro Pro Lys 
            500                 505                 510         


Ala Glu Ala Gln Glu Asn Gly Asp His Arg Glu Val Lys Val Lys Val 
        515                 520                 525             


Glu Pro Ile Pro Ala Ile Gly His Ala Thr Leu Gly Thr Ala Ser Arg 
    530                 535                 540                 


Ile Ile Gln Thr Ala Gln Thr Thr Pro Val Gln Thr Val Thr Ile Val 
545                 550                 555                 560 


Gln Gln Ala Pro Leu Gly Gln His Gln Leu Pro Ile Lys Thr Val Thr 
                565                 570                 575     


Gln Asn Gly Thr His Val Ala Ser Val Pro Thr Ala Val His Gly Gln 
            580                 585                 590         


Val Asn Asn Ala Ala Ala Ser Pro Leu His Met Leu Ala Thr His Ala 
        595                 600                 605             


Ser Ala Ser Ala Ser Leu Pro Thr Lys Arg His Asn Gly Asp Gln Pro 
    610                 615                 620                 


Glu Gln Pro Glu Leu Lys Arg Ile Lys Thr Glu Asp Gly Glu Gly Ile 
625                 630                 635                 640 


Val Ile Ala Leu Ser Val Asp Thr Pro Pro Ala Ala Val Arg Glu Lys 
                645                 650                 655     


Gly Val Gln Asn 
            660 


<210>  4150
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXL1__Homo_sapiens__NP_005241

<400>  4150

Met Ser His Leu Phe Asp Pro Arg Leu Pro Ala Leu Ala Ala Ser Pro 
1               5                   10                  15      


Met Leu Tyr Leu Tyr Gly Pro Glu Arg Pro Gly Leu Pro Leu Ala Phe 
            20                  25                  30          


Ala Pro Ala Ala Ala Leu Ala Ala Ser Gly Arg Ala Glu Thr Pro Gln 
        35                  40                  45              


Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile Ala Met Ala Ile Gln Asp 
    50                  55                  60                  


Ala Pro Glu Gln Arg Val Thr Leu Asn Gly Ile Tyr Gln Phe Ile Met 
65                  70                  75                  80  


Asp Arg Phe Pro Phe Tyr His Asp Asn Arg Gln Gly Trp Gln Asn Ser 
                85                  90                  95      


Ile Arg His Asn Leu Ser Leu Asn Asp Cys Phe Val Lys Val Pro Arg 
            100                 105                 110         


Glu Lys Gly Arg Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro Arg 
        115                 120                 125             


Cys Leu Asp Met Phe Glu Asn Gly Asn Tyr Arg Arg Arg Lys Arg Lys 
    130                 135                 140                 


Pro Lys Pro Gly Pro Gly Ala Pro Glu Ala Lys Arg Pro Arg Ala Glu 
145                 150                 155                 160 


Thr His Gln Arg Ser Ala Glu Ala Gln Pro Glu Ala Gly Ser Gly Ala 
                165                 170                 175     


Gly Gly Ser Gly Pro Ala Ile Ser Arg Leu Gln Ala Ala Pro Ala Gly 
            180                 185                 190         


Pro Ser Pro Leu Leu Asp Gly Pro Ser Pro Pro Ala Pro Leu His Trp 
        195                 200                 205             


Pro Gly Thr Ala Ser Pro Asn Glu Asp Ala Gly Asp Ala Ala Gln Gly 
    210                 215                 220                 


Ala Ala Ala Val Ala Val Gly Gln Ala Ala Arg Thr Gly Asp Gly Pro 
225                 230                 235                 240 


Gly Ser Pro Leu Arg Pro Ala Ser Arg Ser Ser Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Ser Lys Ser Phe Ser Ile Asp Ser Ile Leu Ala Gly Lys Gln Gly 
            260                 265                 270         


Gln Lys Pro Pro Ser Gly Asp Glu Leu Leu Gly Gly Ala Lys Pro Gly 
        275                 280                 285             


Pro Gly Gly Arg Leu Gly Ala Ser Leu Leu Ala Ala Ser Ser Ser Leu 
    290                 295                 300                 


Arg Pro Pro Phe Asn Ala Ser Leu Met Leu Asp Pro His Val Gln Gly 
305                 310                 315                 320 


Gly Phe Tyr Gln Leu Gly Ile Pro Phe Leu Ser Tyr Phe Pro Leu Gln 
                325                 330                 335     


Val Pro Asp Thr Val Leu His Phe Gln 
            340                 345 


<210>  4151
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXL2__Homo_sapiens__NP_075555

<400>  4151

Met Met Ala Ser Tyr Pro Glu Pro Glu Asp Ala Ala Gly Ala Leu Leu 
1               5                   10                  15      


Ala Pro Glu Thr Gly Arg Thr Val Lys Glu Pro Glu Gly Pro Pro Pro 
            20                  25                  30          


Ser Pro Gly Lys Gly Gly Gly Gly Gly Gly Gly Thr Ala Pro Glu Lys 
        35                  40                  45              


Pro Asp Pro Ala Gln Lys Pro Pro Tyr Ser Tyr Val Ala Leu Ile Ala 
    50                  55                  60                  


Met Ala Ile Arg Glu Ser Ala Glu Lys Arg Leu Thr Leu Ser Gly Ile 
65                  70                  75                  80  


Tyr Gln Tyr Ile Ile Ala Lys Phe Pro Phe Tyr Glu Lys Asn Lys Lys 
                85                  90                  95      


Gly Trp Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn Glu Cys Phe 
            100                 105                 110         


Ile Lys Val Pro Arg Glu Gly Gly Gly Glu Arg Lys Gly Asn Tyr Trp 
        115                 120                 125             


Thr Leu Asp Pro Ala Cys Glu Asp Met Phe Glu Lys Gly Asn Tyr Arg 
    130                 135                 140                 


Arg Arg Arg Arg Met Lys Arg Pro Phe Arg Pro Pro Pro Ala His Phe 
145                 150                 155                 160 


Gln Pro Gly Lys Gly Leu Phe Gly Ala Gly Gly Ala Ala Gly Gly Cys 
                165                 170                 175     


Gly Val Ala Gly Ala Gly Ala Asp Gly Tyr Gly Tyr Leu Ala Pro Pro 
            180                 185                 190         


Lys Tyr Leu Gln Ser Gly Phe Leu Asn Asn Ser Trp Pro Leu Pro Gln 
        195                 200                 205             


Pro Pro Ser Pro Met Pro Tyr Ala Ser Cys Gln Met Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Ser Pro Gly 
225                 230                 235                 240 


Ala Ala Ala Val Val Lys Gly Leu Ala Gly Pro Ala Ala Ser Tyr Gly 
                245                 250                 255     


Pro Tyr Thr Arg Val Gln Ser Met Ala Leu Pro Pro Gly Val Val Asn 
            260                 265                 270         


Ser Tyr Asn Gly Leu Gly Gly Pro Pro Ala Ala Pro Pro Pro Pro Pro 
        275                 280                 285             


His Pro His Pro His Pro His Ala His His Leu His Ala Ala Ala Ala 
    290                 295                 300                 


Pro Pro Pro Ala Pro Pro His His Gly Ala Ala Ala Pro Pro Pro Gly 
305                 310                 315                 320 


Gln Leu Ser Pro Ala Ser Pro Ala Thr Ala Ala Pro Pro Ala Pro Ala 
                325                 330                 335     


Pro Thr Ser Ala Pro Gly Leu Gln Phe Ala Cys Ala Arg Gln Pro Glu 
            340                 345                 350         


Leu Ala Met Met His Cys Ser Tyr Trp Asp His Asp Ser Lys Thr Gly 
        355                 360                 365             


Ala Leu His Ser Arg Leu Asp Leu 
    370                 375     


<210>  4152
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXM1__Homo_sapiens__NP_068772

<400>  4152

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala Pro 
            420                 425                 430         


Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly Glu 
        435                 440                 445             


Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu Ile 
    450                 455                 460                 


Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val Glu 
465                 470                 475                 480 


Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys Glu 
                485                 490                 495     


Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro Arg 
            500                 505                 510         


Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val Ser 
        515                 520                 525             


Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg Ser 
    530                 535                 540                 


Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu Leu 
545                 550                 555                 560 


Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu Pro 
                565                 570                 575     


Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser Gln 
            580                 585                 590         


Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Ile 
        595                 600                 605             


Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser Trp 
    610                 615                 620                 


Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val 
625                 630                 635                 640 


Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly Leu 
                645                 650                 655     


Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu Ser 
            660                 665                 670         


Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val Pro 
        675                 680                 685             


Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly Ser 
    690                 695                 700                 


Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr Glu 
705                 710                 715                 720 


Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu 
                725                 730                 735     


Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp Asn 
            740                 745                 750         


Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
        755                 760             


<210>  4153
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXN1__Homo_sapiens__XP_005258103

<400>  4153

Met Val Ser Leu Pro Pro Pro Gln Ser Asp Val Thr Leu Pro Gly Pro 
1               5                   10                  15      


Thr Arg Leu Glu Gly Glu Arg Gln Gly Asp Leu Met Gln Ala Pro Gly 
            20                  25                  30          


Leu Pro Gly Ser Pro Ala Pro Gln Ser Lys His Ala Gly Phe Ser Cys 
        35                  40                  45              


Ser Ser Phe Val Ser Asp Gly Pro Pro Glu Arg Thr Pro Ser Leu Pro 
    50                  55                  60                  


Pro His Ser Pro Arg Ile Ala Ser Pro Gly Pro Glu Gln Val Gln Gly 
65                  70                  75                  80  


His Cys Pro Ala Gly Pro Gly Pro Gly Pro Phe Arg Leu Ser Pro Ser 
                85                  90                  95      


Asp Lys Tyr Pro Gly Phe Gly Phe Glu Glu Ala Ala Ala Ser Ser Pro 
            100                 105                 110         


Gly Arg Phe Leu Lys Gly Ser His Ala Pro Phe His Pro Tyr Lys Arg 
        115                 120                 125             


Pro Phe His Glu Asp Val Phe Pro Glu Ala Glu Thr Thr Leu Ala Leu 
    130                 135                 140                 


Lys Gly His Ser Phe Lys Thr Pro Gly Pro Leu Glu Ala Phe Glu Glu 
145                 150                 155                 160 


Ile Pro Val Asp Val Ala Glu Ala Glu Ala Phe Leu Pro Gly Phe Ser 
                165                 170                 175     


Ala Glu Ala Trp Cys Asn Gly Leu Pro Tyr Pro Ser Gln Glu His Gly 
            180                 185                 190         


Pro Gln Val Leu Gly Ser Glu Val Lys Val Lys Pro Pro Val Leu Glu 
        195                 200                 205             


Ser Gly Ala Gly Met Phe Cys Tyr Gln Pro Pro Leu Gln His Met Tyr 
    210                 215                 220                 


Cys Ser Ser Gln Pro Pro Phe His Gln Tyr Ser Pro Gly Gly Gly Ser 
225                 230                 235                 240 


Tyr Pro Ile Pro Tyr Leu Gly Ser Ser His Tyr Gln Tyr Gln Arg Met 
                245                 250                 255     


Ala Pro Gln Ala Ser Thr Asp Gly His Gln Pro Leu Phe Pro Lys Pro 
            260                 265                 270         


Ile Tyr Ser Tyr Ser Ile Leu Ile Phe Met Ala Leu Lys Asn Ser Lys 
        275                 280                 285             


Thr Gly Ser Leu Pro Val Ser Glu Ile Tyr Asn Phe Met Thr Glu His 
    290                 295                 300                 


Phe Pro Tyr Phe Lys Thr Ala Pro Asp Gly Trp Lys Asn Ser Val Arg 
305                 310                 315                 320 


His Asn Leu Ser Leu Asn Lys Cys Phe Glu Lys Val Glu Asn Lys Ser 
                325                 330                 335     


Gly Ser Ser Ser Arg Lys Gly Cys Leu Trp Ala Leu Asn Pro Ala Lys 
            340                 345                 350         


Ile Asp Lys Met Gln Glu Glu Leu Gln Lys Trp Lys Arg Lys Asp Pro 
        355                 360                 365             


Ile Ala Val Arg Lys Ser Met Ala Lys Pro Glu Glu Leu Asp Ser Leu 
    370                 375                 380                 


Ile Gly Asp Lys Arg Glu Lys Leu Gly Ser Pro Leu Leu Gly Cys Pro 
385                 390                 395                 400 


Pro Pro Gly Leu Ser Gly Ser Gly Pro Ile Arg Pro Leu Ala Pro Pro 
                405                 410                 415     


Ala Gly Leu Ser Pro Pro Leu His Ser Leu His Pro Ala Pro Gly Pro 
            420                 425                 430         


Ile Pro Gly Lys Asn Pro Leu Gln Asp Leu Leu Met Gly His Thr Pro 
        435                 440                 445             


Ser Cys Tyr Gly Gln Thr Tyr Leu His Leu Ser Pro Gly Leu Ala Pro 
    450                 455                 460                 


Pro Gly Pro Pro Gln Pro Leu Phe Pro Gln Pro Asp Gly His Leu Glu 
465                 470                 475                 480 


Leu Arg Ala Gln Pro Gly Thr Pro Gln Asp Ser Pro Leu Pro Ala His 
                485                 490                 495     


Thr Pro Pro Ser His Ser Ala Lys Leu Leu Ala Glu Pro Ser Pro Ala 
            500                 505                 510         


Arg Thr Met His Asp Thr Leu Leu Pro Asp Gly Asp Leu Gly Thr Asp 
        515                 520                 525             


Leu Asp Ala Ile Asn Pro Ser Leu Thr Asp Phe Asp Phe Gln Gly Asn 
    530                 535                 540                 


Leu Trp Glu Gln Leu Lys Asp Asp Ser Leu Ala Leu Asp Pro Leu Val 
545                 550                 555                 560 


Leu Val Thr Ser Ser Pro Thr Ser Ser Ser Met Pro Pro Pro Gln Pro 
                565                 570                 575     


Pro Pro His Cys Phe Pro Pro Gly Pro Cys Leu Thr Glu Thr Gly Ser 
            580                 585                 590         


Gly Ala Gly Asp Leu Ala Ala Pro Gly Ser Gly Gly Ser Gly Ala Leu 
        595                 600                 605             


Gly Asp Leu His Leu Thr Thr Leu Tyr Ser Ala Phe Met Glu Leu Glu 
    610                 615                 620                 


Pro Thr Pro Pro Thr Ala Pro Ala Gly Pro Ser Val Tyr Leu Ser Pro 
625                 630                 635                 640 


Ser Ser Lys Pro Val Ala Leu Ala 
                645             


<210>  4154
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXN2__Homo_sapiens__NP_002149

<400>  4154

Met Gly Pro Val Ile Gly Met Thr Pro Asp Lys Arg Ala Glu Thr Pro 
1               5                   10                  15      


Gly Ala Glu Lys Ile Ala Gly Leu Ser Gln Ile Tyr Lys Met Gly Ser 
            20                  25                  30          


Leu Pro Glu Ala Val Asp Ala Ala Arg Pro Lys Ala Thr Leu Val Asp 
        35                  40                  45              


Ser Glu Ser Ala Asp Asp Glu Leu Thr Asn Leu Asn Trp Leu His Glu 
    50                  55                  60                  


Ser Thr Asn Leu Leu Thr Asn Phe Ser Leu Gly Ser Glu Gly Leu Pro 
65                  70                  75                  80  


Ile Val Ser Pro Leu Tyr Asp Ile Glu Gly Asp Asp Val Pro Ser Phe 
                85                  90                  95      


Gly Pro Ala Cys Tyr Gln Asn Pro Glu Lys Lys Ser Ala Thr Ser Lys 
            100                 105                 110         


Pro Pro Tyr Ser Phe Ser Leu Leu Ile Tyr Met Ala Ile Glu His Ser 
        115                 120                 125             


Pro Asn Lys Cys Leu Pro Val Lys Glu Ile Tyr Ser Trp Ile Leu Asp 
    130                 135                 140                 


His Phe Pro Tyr Phe Ala Thr Ala Pro Thr Gly Trp Lys Asn Ser Val 
145                 150                 155                 160 


Arg His Asn Leu Ser Leu Asn Lys Cys Phe Gln Lys Val Glu Arg Ser 
                165                 170                 175     


His Gly Lys Val Asn Gly Lys Gly Ser Leu Trp Cys Val Asp Pro Glu 
            180                 185                 190         


Tyr Lys Pro Asn Leu Ile Gln Ala Leu Lys Lys Gln Pro Phe Ser Ser 
        195                 200                 205             


Ala Ser Ser Gln Asn Gly Ser Leu Ser Pro His Tyr Leu Ser Ser Val 
    210                 215                 220                 


Ile Lys Gln Asn Gln Val Arg Asn Leu Lys Glu Ser Asp Ile Asp Ala 
225                 230                 235                 240 


Ala Ala Ala Met Met Leu Leu Asn Thr Ser Ile Glu Gln Gly Ile Leu 
                245                 250                 255     


Glu Cys Glu Lys Pro Leu Pro Leu Lys Thr Ala Leu Gln Lys Lys Arg 
            260                 265                 270         


Ser Tyr Gly Asn Ala Phe His His Pro Ser Ala Val Arg Leu Gln Glu 
        275                 280                 285             


Ser Asp Ser Leu Ala Thr Ser Ile Asp Pro Lys Glu Asp His Asn Tyr 
    290                 295                 300                 


Ser Ala Ser Ser Met Ala Ala Gln Arg Cys Ala Ser Arg Ser Ser Val 
305                 310                 315                 320 


Ser Ser Leu Ser Ser Val Asp Glu Val Tyr Glu Phe Ile Pro Lys Asn 
                325                 330                 335     


Ser His Val Gly Ser Asp Gly Ser Glu Gly Phe His Ser Glu Glu Asp 
            340                 345                 350         


Thr Asp Val Asp Tyr Glu Asp Asp Pro Leu Gly Asp Ser Gly Tyr Ala 
        355                 360                 365             


Ser Gln Pro Cys Ala Lys Ile Ser Glu Lys Gly Gln Ser Gly Lys Lys 
    370                 375                 380                 


Met Arg Lys Gln Thr Cys Gln Glu Ile Asp Glu Glu Leu Lys Glu Ala 
385                 390                 395                 400 


Ala Gly Ser Leu Leu His Leu Ala Gly Ile Arg Thr Cys Leu Gly Ser 
                405                 410                 415     


Leu Ile Ser Thr Ala Lys Thr Gln Asn Gln Lys Gln Arg Lys Lys 
            420                 425                 430     


<210>  4155
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXN3__Homo_sapiens__NP_001078940

<400>  4155

Met Gly Pro Val Met Pro Pro Ser Lys Lys Pro Glu Ser Ser Gly Ile 
1               5                   10                  15      


Ser Val Ser Ser Gly Leu Ser Gln Cys Tyr Gly Gly Ser Gly Phe Ser 
            20                  25                  30          


Lys Ala Leu Gln Glu Asp Asp Asp Leu Asp Phe Ser Leu Pro Asp Ile 
        35                  40                  45              


Arg Leu Glu Glu Gly Ala Met Glu Asp Glu Glu Leu Thr Asn Leu Asn 
    50                  55                  60                  


Trp Leu His Glu Ser Lys Asn Leu Leu Lys Ser Phe Gly Glu Ser Val 
65                  70                  75                  80  


Leu Arg Ser Val Ser Pro Val Gln Asp Leu Asp Asp Asp Thr Pro Pro 
                85                  90                  95      


Ser Pro Ala His Ser Asp Met Pro Tyr Asp Ala Arg Gln Asn Pro Asn 
            100                 105                 110         


Cys Lys Pro Pro Tyr Ser Phe Ser Cys Leu Ile Phe Met Ala Ile Glu 
        115                 120                 125             


Asp Ser Pro Thr Lys Arg Leu Pro Val Lys Asp Ile Tyr Asn Trp Ile 
    130                 135                 140                 


Leu Glu His Phe Pro Tyr Phe Ala Asn Ala Pro Thr Gly Trp Lys Asn 
145                 150                 155                 160 


Ser Val Arg His Asn Leu Ser Leu Asn Lys Cys Phe Lys Lys Val Asp 
                165                 170                 175     


Lys Glu Arg Ser Gln Ser Ile Gly Lys Gly Ser Leu Trp Cys Ile Asp 
            180                 185                 190         


Pro Glu Tyr Arg Gln Asn Leu Ile Gln Ala Leu Lys Lys Thr Pro Tyr 
        195                 200                 205             


His Pro His Pro His Val Phe Asn Thr Pro Pro Thr Cys Pro Gln Ala 
    210                 215                 220                 


Tyr Gln Ser Thr Ser Gly Pro Pro Ile Trp Pro Gly Ser Thr Phe Phe 
225                 230                 235                 240 


Lys Arg Asn Gly Ala Leu Leu Gln Asp Pro Asp Ile Asp Ala Ala Ser 
                245                 250                 255     


Ala Met Met Leu Leu Asn Thr Pro Pro Glu Ile Gln Ala Gly Phe Pro 
            260                 265                 270         


Pro Gly Val Ile Gln Asn Gly Ala Arg Val Leu Ser Arg Gly Leu Phe 
        275                 280                 285             


Pro Gly Val Arg Pro Leu Pro Ile Thr Pro Ile Gly Val Thr Ala Ala 
    290                 295                 300                 


Met Arg Asn Gly Ile Thr Ser Cys Arg Met Arg Thr Glu Ser Glu Pro 
305                 310                 315                 320 


Ser Cys Gly Ser Pro Val Val Ser Gly Asp Pro Lys Glu Asp His Asn 
                325                 330                 335     


Tyr Ser Ser Ala Lys Ser Ser Asn Ala Arg Ser Thr Ser Pro Thr Ser 
            340                 345                 350         


Asp Ser Ile Ser Ser Ser Ser Ser Ser Ala Asp Asp His Tyr Glu Phe 
        355                 360                 365             


Ala Thr Lys Gly Ser Gln Glu Gly Ser Glu Gly Ser Glu Gly Ser Phe 
    370                 375                 380                 


Arg Ser His Glu Ser Pro Ser Asp Thr Glu Glu Asp Asp Arg Lys His 
385                 390                 395                 400 


Ser Gln Lys Glu Pro Lys Asp Ser Leu Gly Asp Ser Gly Tyr Ala Ser 
                405                 410                 415     


Gln His Lys Lys Arg Gln His Phe Ala Lys Ala Arg Lys Val Pro Ser 
            420                 425                 430         


Asp Thr Leu Pro Leu Lys Lys Arg Arg Thr Glu Lys Pro Pro Glu Ser 
        435                 440                 445             


Asp Asp Glu Glu Met Lys Glu Ala Ala Gly Ser Leu Leu His Leu Ala 
    450                 455                 460                 


Gly Ile Arg Ser Cys Leu Asn Asn Ile Thr Asn Arg Thr Ala Lys Gly 
465                 470                 475                 480 


Gln Lys Glu Gln Lys Glu Thr Thr Lys Asn 
                485                 490 


<210>  4156
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXO1__Homo_sapiens__NP_002006

<400>  4156

Met Ala Glu Ala Pro Gln Val Val Glu Ile Asp Pro Asp Phe Glu Pro 
1               5                   10                  15      


Leu Pro Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe 
            20                  25                  30          


Ser Gln Ser Asn Ser Ala Thr Ser Ser Pro Ala Pro Ser Gly Ser Ala 
        35                  40                  45              


Ala Ala Asn Pro Asp Ala Ala Ala Gly Leu Pro Ser Ala Ser Ala Ala 
    50                  55                  60                  


Ala Val Ser Ala Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Pro Gln Ala Pro Gly Ser Val Ala Ala Ala Val Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Thr Gly Gly Leu Cys Gly Asp Phe Gln Gly 
            100                 105                 110         


Pro Glu Ala Gly Cys Leu His Pro Ala Pro Pro Gln Pro Pro Pro Pro 
        115                 120                 125             


Gly Pro Leu Ser Gln His Pro Pro Val Pro Pro Ala Ala Ala Gly Pro 
    130                 135                 140                 


Leu Ala Gly Gln Pro Arg Lys Ser Ser Ser Ser Arg Arg Asn Ala Trp 
145                 150                 155                 160 


Gly Asn Leu Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser 
                165                 170                 175     


Ala Glu Lys Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys 
            180                 185                 190         


Ser Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly 
        195                 200                 205             


Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile 
    210                 215                 220                 


Arg Val Gln Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn 
225                 230                 235                 240 


Pro Glu Gly Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser 
                245                 250                 255     


Met Asp Asn Asn Ser Lys Phe Ala Lys Ser Arg Ser Arg Ala Ala Lys 
            260                 265                 270         


Lys Lys Ala Ser Leu Gln Ser Gly Gln Glu Gly Ala Gly Asp Ser Pro 
        275                 280                 285             


Gly Ser Gln Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn 
    290                 295                 300                 


Asp Asp Phe Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn 
305                 310                 315                 320 


Ala Ser Thr Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp 
                325                 330                 335     


Asp Leu Gly Glu Gly Asp Val His Ser Met Val Tyr Pro Pro Ser Ala 
            340                 345                 350         


Ala Lys Met Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro 
        355                 360                 365             


Glu Asn Met Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro 
    370                 375                 380                 


Thr Ser Leu Thr Val Ser Thr Gln Ser Ser Pro Gly Thr Met Met Gln 
385                 390                 395                 400 


Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser 
                405                 410                 415     


Pro Ser Pro Asn Tyr Gln Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser 
            420                 425                 430         


Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln Asp Asn Lys Ser Ser 
        435                 440                 445             


Tyr Gly Gly Met Ser Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu 
    450                 455                 460                 


Leu Leu Thr Ser Asp Ser Pro Pro His Asn Asp Ile Met Thr Pro Val 
465                 470                 475                 480 


Asp Pro Gly Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val 
                485                 490                 495     


Met Met Gly Pro Asn Ser Val Met Ser Thr Tyr Gly Ser Gln Ala Ser 
            500                 505                 510         


His Asn Lys Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala 
        515                 520                 525             


Gln Gln Thr Ser Ala Val Asn Gly Arg Pro Leu Pro His Thr Val Ser 
    530                 535                 540                 


Thr Met Pro His Thr Ser Gly Met Asn Arg Leu Thr Gln Val Lys Thr 
545                 550                 555                 560 


Pro Val Gln Val Pro Leu Pro His Pro Met Gln Met Ser Ala Leu Gly 
                565                 570                 575     


Gly Tyr Ser Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Leu 
            580                 585                 590         


Leu His Gln Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu 
        595                 600                 605             


Arg Leu Asp Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp 
    610                 615                 620                 


Gly Asp Thr Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser 
625                 630                 635                 640 


Phe Pro His Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
                645                 650                 655 


<210>  4157
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXO3__Homo_sapiens__NP_963853

<400>  4157

Met Ala Glu Ala Pro Ala Ser Pro Ala Pro Leu Ser Pro Leu Glu Val 
1               5                   10                  15      


Glu Leu Asp Pro Glu Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Gln Arg Pro Glu Leu Gln Ala Ser Pro Ala Lys Pro Ser 
        35                  40                  45              


Gly Glu Thr Ala Ala Asp Ser Met Ile Pro Glu Glu Glu Asp Asp Glu 
    50                  55                  60                  


Asp Asp Glu Asp Gly Gly Gly Arg Ala Gly Ser Ala Met Ala Ile Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Thr Leu Gly Ser Gly Leu Leu Leu Glu Asp 
                85                  90                  95      


Ser Ala Arg Val Leu Ala Pro Gly Gly Gln Asp Pro Gly Ser Gly Pro 
            100                 105                 110         


Ala Thr Ala Ala Gly Gly Leu Ser Gly Gly Thr Gln Ala Leu Leu Gln 
        115                 120                 125             


Pro Gln Gln Pro Leu Pro Pro Pro Gln Pro Gly Ala Ala Gly Gly Ser 
    130                 135                 140                 


Gly Gln Pro Arg Lys Cys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu 
145                 150                 155                 160 


Ser Tyr Ala Asp Leu Ile Thr Arg Ala Ile Glu Ser Ser Pro Asp Lys 
                165                 170                 175     


Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Arg Cys Val Pro 
            180                 185                 190         


Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn 
        195                 200                 205             


Ser Ile Arg His Asn Leu Ser Leu His Ser Arg Phe Met Arg Val Gln 
    210                 215                 220                 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Ile Ile Asn Pro Asp Gly 
225                 230                 235                 240 


Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn 
                245                 250                 255     


Ser Asn Lys Tyr Thr Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala 
            260                 265                 270         


Ala Leu Gln Thr Ala Pro Glu Ser Ala Asp Asp Ser Pro Ser Gln Leu 
        275                 280                 285             


Ser Lys Trp Pro Gly Ser Pro Thr Ser Arg Ser Ser Asp Glu Leu Asp 
    290                 295                 300                 


Ala Trp Thr Asp Phe Arg Ser Arg Thr Asn Ser Asn Ala Ser Thr Val 
305                 310                 315                 320 


Ser Gly Arg Leu Ser Pro Ile Met Ala Ser Thr Glu Leu Asp Glu Val 
                325                 330                 335     


Gln Asp Asp Asp Ala Pro Leu Ser Pro Met Leu Tyr Ser Ser Ser Ala 
            340                 345                 350         


Ser Leu Ser Pro Ser Val Ser Lys Pro Cys Thr Val Glu Leu Pro Arg 
        355                 360                 365             


Leu Thr Asp Met Ala Gly Thr Met Asn Leu Asn Asp Gly Leu Thr Glu 
    370                 375                 380                 


Asn Leu Met Asp Asp Leu Leu Asp Asn Ile Thr Leu Pro Pro Ser Gln 
385                 390                 395                 400 


Pro Ser Pro Thr Gly Gly Leu Met Gln Arg Ser Ser Ser Phe Pro Tyr 
                405                 410                 415     


Thr Thr Lys Gly Ser Gly Leu Gly Ser Pro Thr Ser Ser Phe Asn Ser 
            420                 425                 430         


Thr Val Phe Gly Pro Ser Ser Leu Asn Ser Leu Arg Gln Ser Pro Met 
        435                 440                 445             


Gln Thr Ile Gln Glu Asn Lys Pro Ala Thr Phe Ser Ser Met Ser His 
    450                 455                 460                 


Tyr Gly Asn Gln Thr Leu Gln Asp Leu Leu Thr Ser Asp Ser Leu Ser 
465                 470                 475                 480 


His Ser Asp Val Met Met Thr Gln Ser Asp Pro Leu Met Ser Gln Ala 
                485                 490                 495     


Ser Thr Ala Val Ser Ala Gln Asn Ser Arg Arg Asn Val Met Leu Arg 
            500                 505                 510         


Asn Asp Pro Met Met Ser Phe Ala Ala Gln Pro Asn Gln Gly Ser Leu 
        515                 520                 525             


Val Asn Gln Asn Leu Leu His His Gln His Gln Thr Gln Gly Ala Leu 
    530                 535                 540                 


Gly Gly Ser Arg Ala Leu Ser Asn Ser Val Ser Asn Met Gly Leu Ser 
545                 550                 555                 560 


Glu Ser Ser Ser Leu Gly Ser Ala Lys His Gln Gln Gln Ser Pro Val 
                565                 570                 575     


Ser Gln Ser Met Gln Thr Leu Ser Asp Ser Leu Ser Gly Ser Ser Leu 
            580                 585                 590         


Tyr Ser Thr Ser Ala Asn Leu Pro Val Met Gly His Glu Lys Phe Pro 
        595                 600                 605             


Ser Asp Leu Asp Leu Asp Met Phe Asn Gly Ser Leu Glu Cys Asp Met 
    610                 615                 620                 


Glu Ser Ile Ile Arg Ser Glu Leu Met Asp Ala Asp Gly Leu Asp Phe 
625                 630                 635                 640 


Asn Phe Asp Ser Leu Ile Ser Thr Gln Asn Val Val Gly Leu Asn Val 
                645                 650                 655     


Gly Asn Phe Thr Gly Ala Lys Gln Ala Ser Ser Gln Ser Trp Val Pro 
            660                 665                 670         


Gly 
    


<210>  4158
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXO4__Homo_sapiens__NP_001164402

<400>  4158

Met Asp Pro Gly Asn Glu Asn Ser Ala Thr Glu Ala Ala Ala Ile Ile 
1               5                   10                  15      


Asp Leu Asp Pro Asp Phe Glu Pro Gln Ser Arg Pro Arg Ser Cys Thr 
            20                  25                  30          


Trp Pro Leu Pro Arg Pro Glu Ile Ala Asn Gln Pro Ser Glu Pro Pro 
        35                  40                  45              


Glu Val Glu Pro Asp Leu Gly Glu Lys Ala Ile Glu Ser Ala Pro Glu 
    50                  55                  60                  


Lys Arg Leu Thr Leu Ala Gln Ile Tyr Glu Trp Met Val Arg Thr Val 
65                  70                  75                  80  


Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys 
                85                  90                  95      


Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile Lys Val 
            100                 105                 110         


His Asn Glu Ala Thr Gly Lys Ser Ser Trp Trp Met Leu Asn Pro Glu 
        115                 120                 125             


Gly Gly Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Ala Ser Met Asp 
    130                 135                 140                 


Ser Ser Ser Lys Leu Leu Arg Gly Arg Ser Lys Ala Pro Lys Lys Lys 
145                 150                 155                 160 


Pro Ser Val Leu Pro Ala Pro Pro Glu Gly Ala Thr Pro Thr Ser Pro 
                165                 170                 175     


Val Gly His Phe Ala Lys Trp Ser Gly Ser Pro Cys Ser Arg Asn Arg 
            180                 185                 190         


Glu Glu Ala Asp Met Trp Thr Thr Phe Arg Pro Arg Ser Ser Ser Asn 
        195                 200                 205             


Ala Ser Ser Val Ser Thr Arg Leu Ser Pro Leu Arg Pro Glu Ser Glu 
    210                 215                 220                 


Val Leu Ala Glu Glu Ile Pro Ala Ser Val Ser Ser Tyr Ala Gly Gly 
225                 230                 235                 240 


Val Pro Pro Thr Leu Asn Glu Gly Leu Glu Leu Leu Asp Gly Leu Asn 
                245                 250                 255     


Leu Thr Ser Ser His Ser Leu Leu Ser Arg Ser Gly Leu Ser Gly Phe 
            260                 265                 270         


Ser Leu Gln His Pro Gly Val Thr Gly Pro Leu His Thr Tyr Ser Ser 
        275                 280                 285             


Ser Leu Phe Ser Pro Ala Glu Gly Pro Leu Ser Ala Gly Glu Gly Cys 
    290                 295                 300                 


Phe Ser Ser Ser Gln Ala Leu Glu Ala Leu Leu Thr Ser Asp Thr Pro 
305                 310                 315                 320 


Pro Pro Pro Ala Asp Val Leu Met Thr Gln Val Asp Pro Ile Leu Ser 
                325                 330                 335     


Gln Ala Pro Thr Leu Leu Leu Leu Gly Gly Leu Pro Ser Ser Ser Lys 
            340                 345                 350         


Leu Ala Thr Gly Val Gly Leu Cys Pro Lys Pro Leu Glu Ala Pro Gly 
        355                 360                 365             


Pro Ser Ser Leu Val Pro Thr Leu Ser Met Ile Ala Pro Pro Pro Val 
    370                 375                 380                 


Met Ala Ser Ala Pro Ile Pro Lys Ala Leu Gly Thr Pro Val Leu Thr 
385                 390                 395                 400 


Pro Pro Thr Glu Ala Ala Ser Gln Asp Arg Met Pro Gln Asp Leu Asp 
                405                 410                 415     


Leu Asp Met Tyr Met Glu Asn Leu Glu Cys Asp Met Asp Asn Ile Ile 
            420                 425                 430         


Ser Asp Leu Met Asp Glu Gly Glu Gly Leu Asp Phe Asn Phe Glu Pro 
        435                 440                 445             


Asp Pro 
    450 


<210>  4159
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXO6__Homo_sapiens__NP_001278210

<400>  4159

Met Ala Ala Lys Leu Arg Ala His Gln Val Asp Val Asp Pro Asp Phe 
1               5                   10                  15      


Ala Pro Gln Ser Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Gln Pro 
            20                  25                  30          


Asp Leu Ala Gly Asp Glu Asp Gly Ala Leu Gly Ala Gly Val Ala Glu 
        35                  40                  45              


Gly Ala Glu Asp Cys Gly Pro Glu Arg Arg Ala Thr Ala Pro Ala Met 
    50                  55                  60                  


Ala Pro Ala Pro Pro Leu Gly Ala Glu Val Gly Pro Leu Arg Lys Ala 
65                  70                  75                  80  


Lys Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu Ser Tyr Ala Asp Leu 
                85                  90                  95      


Ile Thr Lys Ala Ile Glu Ser Ala Pro Asp Lys Arg Leu Thr Leu Ser 
            100                 105                 110         


Gln Ile Tyr Asp Trp Met Val Arg Tyr Val Pro Tyr Phe Lys Asp Lys 
        115                 120                 125             


Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn Ser Ile Arg His Asn 
    130                 135                 140                 


Leu Ser Leu His Thr Arg Phe Ile Arg Val Gln Asn Glu Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Ser Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Thr Gly Lys 
                165                 170                 175     


Thr Pro Arg Arg Arg Ala Val Ser Met Asp Asn Gly Ala Lys Phe Leu 
            180                 185                 190         


Arg Ile Lys Gly Lys Ala Ser Lys Lys Lys Gln Leu Gln Ala Pro Glu 
        195                 200                 205             


Arg Ser Pro Asp Asp Ser Ser Pro Ser Ala Pro Ala Pro Gly Pro Val 
    210                 215                 220                 


Pro Ala Ala Ala Lys Trp Ala Ala Ser Pro Ala Ser His Ala Ser Asp 
225                 230                 235                 240 


Asp Tyr Glu Ala Trp Ala Asp Phe Arg Gly Gly Gly Arg Pro Leu Leu 
                245                 250                 255     


Gly Glu Ala Ala Glu Leu Glu Asp Asp Glu Ala Leu Glu Ala Leu Ala 
            260                 265                 270         


Pro Ser Ser Pro Leu Met Tyr Pro Ser Pro Ala Ser Ala Leu Ser Pro 
        275                 280                 285             


Ala Leu Gly Ser Arg Cys Pro Gly Glu Leu Pro Arg Leu Ala Glu Leu 
    290                 295                 300                 


Gly Gly Pro Leu Gly Leu His Gly Gly Gly Gly Ala Gly Leu Pro Glu 
305                 310                 315                 320 


Gly Leu Leu Asp Gly Ala Gln Asp Ala Tyr Gly Pro Arg Ala Arg Ala 
                325                 330                 335     


Gly Thr Pro Ala Tyr Phe Gly Gly Cys Lys Gly Gly Ala Tyr Gly Gly 
            340                 345                 350         


Gly Gly Gly Phe Gly Pro Pro Ala Met Gly Ala Leu Arg Arg Leu Pro 
        355                 360                 365             


Met Gln Thr Ile Gln Glu Asn Lys Gln Ala Ser Phe Val Pro Ala Ala 
    370                 375                 380                 


Ala Pro Phe Arg Pro Gly Ala Leu Pro Ala Leu Leu Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Ala Pro Arg Pro Gly Pro Val Leu Gly Ala Pro Gly Glu Leu Ala 
                405                 410                 415     


Leu Ala Gly Ala Ala Ala Ala Tyr Pro Gly Lys Gly Ala Ala Pro Tyr 
            420                 425                 430         


Ala Pro Pro Ala Pro Ser Arg Ser Ala Leu Ala His Pro Ile Ser Leu 
        435                 440                 445             


Met Thr Leu Pro Gly Glu Ala Gly Ala Ala Gly Leu Ala Pro Ser Gly 
    450                 455                 460                 


His Ala Ala Ala Phe Gly Gly Pro Pro Gly Gly Leu Leu Leu Asp Ala 
465                 470                 475                 480 


Leu Pro Gly Pro Tyr Ala Ala Ala Ala Ala Gly Pro Leu Gly Ala Ala 
                485                 490                 495     


Pro Asp Arg Phe Pro Ala Asp Leu Asp Leu Asp Met Phe Ser Gly Ser 
            500                 505                 510         


Leu Glu Cys Asp Val Glu Ser Ile Ile Leu Asn Asp Phe Met Asp Ser 
        515                 520                 525             


Asp Glu Met Asp Phe Asn Phe Asp Ser Ala Leu Pro Pro Pro Pro Pro 
    530                 535                 540                 


Gly Leu Ala Gly Ala Pro Pro Pro Asn Gln Ser Trp Val Pro Gly 
545                 550                 555                 


<210>  4160
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP1__Homo_sapiens__NP_001012523

<400>  4160

Met Met Gln Glu Ser Gly Thr Glu Thr Lys Ser Asn Gly Ser Ala Ile 
1               5                   10                  15      


Gln Asn Gly Ser Gly Gly Ser Asn His Leu Leu Glu Cys Gly Gly Leu 
            20                  25                  30          


Arg Glu Gly Arg Ser Asn Gly Glu Thr Pro Ala Val Asp Ile Gly Ala 
        35                  40                  45              


Ala Asp Leu Ala His Ala Gln Gln Gln Gln Gln Gln Trp His Leu Ile 
    50                  55                  60                  


Asn His Gln Pro Ser Arg Ser Pro Ser Ser Trp Leu Lys Arg Leu Ile 
65                  70                  75                  80  


Ser Ser Pro Trp Glu Leu Glu Val Leu Gln Val Pro Leu Trp Gly Ala 
                85                  90                  95      


Val Ala Glu Thr Lys Met Ser Gly Pro Val Cys Gln Pro Asn Pro Ser 
            100                 105                 110         


Pro Phe 
        


<210>  4161
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP2__Homo_sapiens__NP_001166237

<400>  4161

Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn 
1               5                   10                  15      


Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg 
            20                  25                  30          


Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu 
        35                  40                  45              


Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu 
    50                  55                  60                  


Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp 
65                  70                  75                  80  


Lys Gln Arg Pro Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro 
                85                  90                  95      


Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val 
            100                 105                 110         


Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val 
        115                 120                 125             


Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu 
    130                 135                 140                 


Gln Leu His Leu Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
            180                 185                 190         


Pro Gly Lys Gln Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


Leu Ala Ala Gln Gln Leu Val Phe Gln Gln Gln Leu Leu Gln Met Gln 
    210                 215                 220                 


Gln Leu Gln Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly Leu 
225                 230                 235                 240 


Ile Ser Ile Pro Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu Pro 
                245                 250                 255     


Gln Ala Gly Leu Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu Val 
            260                 265                 270         


Thr Gly Val His Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly Leu 
        275                 280                 285             


Asp Leu Thr Thr Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr Ser 
    290                 295                 300                 


Lys Ala Ser Pro Pro Ile Thr His His Ser Ile Val Asn Gly Gln Ser 
305                 310                 315                 320 


Ser Val Leu Ser Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr Gly 
                325                 330                 335     


Ala Ser His Thr Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys 
            340                 345                 350         


Glu Ser Ile Cys Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn Asn 
        355                 360                 365             


Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met 
    370                 375                 380                 


Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu Arg 
385                 390                 395                 400 


Leu Gln Ala Met Met Thr His Leu His Met Arg Pro Ser Glu Pro Lys 
                405                 410                 415     


Pro Ser Pro Lys Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser Lys 
            420                 425                 430         


Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr Thr 
        435                 440                 445             


Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile Thr 
    450                 455                 460                 


Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser Asp 
465                 470                 475                 480 


Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu Phe 
                485                 490                 495     


Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile 
            500                 505                 510         


Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn Glu 
        515                 520                 525             


Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn Ala 
    530                 535                 540                 


Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys 
545                 550                 555                 560 


Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu 
                565                 570                 575     


Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro Thr 
            580                 585                 590         


Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu Asn 
        595                 600                 605             


Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu Ser 
    610                 615                 620                 


Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala Val 
625                 630                 635                 640 


His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly Asn 
                645                 650                 655     


Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His Val 
            660                 665                 670         


Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser Leu 
        675                 680                 685             


Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu Ile 
    690                 695                 700                 


Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu 
705                 710                 


<210>  4162
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3__Homo_sapiens__NP_001107849

<400>  4162

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Ser Thr Val Asp Ala His Ala Arg Thr 
65                  70                  75                  80  


Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met Ile Ser Leu 
                85                  90                  95      


Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys Ala Arg Pro 
            100                 105                 110         


Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp Val Ser Arg 
        115                 120                 125             


Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala Pro Arg Lys 
    130                 135                 140                 


Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro Leu Leu Ala 
145                 150                 155                 160 


Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe Glu Glu Pro 
                165                 170                 175     


Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu Asp Glu Lys 
            180                 185                 190         


Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln Ser Leu Glu 
        195                 200                 205             


Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met Gln Ala His 
    210                 215                 220                 


Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val Ala Ser Ser 
225                 230                 235                 240 


Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln Gly Pro Val 
                245                 250                 255     


Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala 
            260                 265                 270         


Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr Phe Pro Glu 
        275                 280                 285             


Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met Arg Pro Pro 
    290                 295                 300                 


Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu 
305                 310                 315                 320 


Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr Arg Met Phe 
                325                 330                 335     


Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala Ile Arg His 
            340                 345                 350         


Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser Glu Lys Gly 
        355                 360                 365             


Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys Arg Ser Gln 
    370                 375                 380                 


Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
385                 390                 395     


<210>  4163
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP4__Homo_sapiens__NP_001012426

<400>  4163

Met Met Val Glu Ser Ala Ser Glu Thr Ile Arg Ser Ala Pro Ser Gly 
1               5                   10                  15      


Gln Asn Gly Val Gly Ser Leu Ser Gly Gln Ala Asp Gly Ser Ser Gly 
            20                  25                  30          


Gly Ala Thr Gly Thr Thr Ala Ser Gly Thr Gly Arg Glu Val Thr Thr 
        35                  40                  45              


Gly Ala Asp Ser Asn Gly Glu Met Ser Pro Ala Glu Leu Leu His Phe 
    50                  55                  60                  


Gln Gln Gln Gln Ala Leu Gln Val Ala Arg Gln Phe Leu Leu Gln Gln 
65                  70                  75                  80  


Ala Ser Gly Leu Ser Ser Pro Gly Asn Asn Asp Ser Lys Gln Ser Ala 
                85                  90                  95      


Ser Ala Val Gln Val Pro Val Ser Val Ala Met Met Ser Pro Gln Met 
            100                 105                 110         


Leu Thr Pro Gln Gln Met Gln Gln Ile Leu Ser Pro Pro Gln Leu Gln 
        115                 120                 125             


Ala Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Leu Gln Glu 
    130                 135                 140                 


Tyr Tyr Lys Lys Gln Gln Glu Gln Leu His Leu Gln Leu Leu Thr Gln 
145                 150                 155                 160 


Gln Gln Ala Gly Lys Pro Gln Pro Lys Glu Ala Leu Gly Asn Lys Gln 
                165                 170                 175     


Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln 
            180                 185                 190         


His Leu Leu Asn Leu Gln Arg Gln Gly Leu Val Ser Leu Gln Pro Asn 
        195                 200                 205             


Gln Ala Ser Gly Pro Leu Gln Thr Leu Pro Gln Ala Ala Val Cys Pro 
    210                 215                 220                 


Thr Asp Leu Pro Gln Leu Trp Lys Gly Glu Gly Ala Pro Gly Gln Pro 
225                 230                 235                 240 


Ala Glu Asp Ser Val Lys Gln Glu Gly Leu Asp Leu Thr Gly Thr Ala 
                245                 250                 255     


Ala Thr Ala Thr Ser Phe Ala Ala Pro Pro Lys Val Ser Pro Pro Leu 
            260                 265                 270         


Ser His His Thr Leu Pro Asn Gly Gln Pro Thr Val Leu Thr Ser Arg 
        275                 280                 285             


Arg Asp Ser Ser Ser His Glu Glu Thr Pro Gly Ser His Pro Leu Tyr 
    290                 295                 300                 


Gly His Gly Glu Cys Lys Trp Pro Gly Cys Glu Thr Leu Cys Glu Asp 
305                 310                 315                 320 


Leu Gly Gln Phe Ile Lys His Leu Asn Thr Glu His Ala Leu Asp Asp 
                325                 330                 335     


Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu 
            340                 345                 350         


Glu Ile Gln Leu Ala Lys Glu Ser Glu Arg Leu Gln Ala Met Met Ala 
        355                 360                 365             


His Leu His Met Arg Pro Ser Glu Pro Lys Pro Phe Ser Gln Pro Leu 
    370                 375                 380                 


Asn Pro Val Pro Gly Ser Ser Ser Phe Ser Lys Val Thr Val Ser Ala 
385                 390                 395                 400 


Ala Asp Ser Phe Pro Asp Gly Leu Val His Pro Pro Thr Ser Ala Ala 
                405                 410                 415     


Ala Pro Val Thr Pro Leu Arg Pro Pro Gly Leu Gly Ser Ala Ser Leu 
            420                 425                 430         


His Gly Gly Gly Pro Ala Arg Arg Arg Ser Ser Asp Lys Phe Cys Ser 
        435                 440                 445             


Pro Ile Ser Ser Glu Leu Ala Gln Asn His Glu Phe Tyr Lys Asn Ala 
    450                 455                 460                 


Asp Val Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile 
465                 470                 475                 480 


Leu Glu Thr Pro Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp 
                485                 490                 495     


Phe Thr Arg Met Phe Ala Tyr Phe Arg Arg Asn Thr Ala Thr Trp Lys 
            500                 505                 510         


Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val 
        515                 520                 525             


Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Arg Glu Tyr Gln 
    530                 535                 540                 


Lys Arg Arg Pro Pro Lys Met Thr Gly Ser Pro Thr Leu Val Lys Asn 
545                 550                 555                 560 


Met Ile Ser Gly Leu Ser Tyr Gly Ala Leu Asn Ala Ser Tyr Gln Ala 
                565                 570                 575     


Ala Leu Ala Glu Ser Ser Phe Pro Leu Leu Asn Ser Pro Gly Met Leu 
            580                 585                 590         


Asn Pro Gly Ser Ala Ser Ser Leu Leu Pro Leu Ser His Asp Asp Val 
        595                 600                 605             


Gly Ala Pro Val Glu Pro Leu Pro Ser Asn Gly Ser Ser Ser Pro Pro 
    610                 615                 620                 


Arg Leu Ser Pro Pro Gln Tyr Ser His Gln Val Gln Val Lys Glu Glu 
625                 630                 635                 640 


Pro Ala Glu Ala Glu Glu Asp Arg Gln Pro Gly Pro Pro Leu Gly Ala 
                645                 650                 655     


Pro Asn Pro Ser Ala Ser Gly Pro Pro Glu Asp Arg Asp Leu Glu Glu 
            660                 665                 670         


Glu Leu Pro Gly Glu Glu Leu Ser 
        675                 680 


<210>  4164
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXQ1__Homo_sapiens__NP_150285

<400>  4164

Met Lys Leu Glu Val Phe Val Pro Arg Ala Ala His Gly Asp Lys Gln 
1               5                   10                  15      


Gly Ser Asp Leu Glu Gly Ala Gly Gly Ser Asp Ala Pro Ser Pro Leu 
            20                  25                  30          


Ser Ala Ala Gly Asp Asp Ser Leu Gly Ser Asp Gly Asp Cys Ala Ala 
        35                  40                  45              


Asn Ser Pro Ala Ala Gly Gly Gly Ala Arg Asp Thr Gln Gly Asp Gly 
    50                  55                  60                  


Glu Gln Ser Ala Gly Gly Gly Pro Gly Ala Glu Glu Ala Ile Pro Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Val Val Ala Glu Gly Ala Glu Ala Gly Ala Ala 
                85                  90                  95      


Gly Pro Gly Ala Gly Gly Ala Gly Ser Gly Glu Gly Ala Arg Ser Lys 
            100                 105                 110         


Pro Tyr Thr Arg Arg Pro Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile 
        115                 120                 125             


Ala Met Ala Ile Arg Asp Ser Ala Gly Gly Arg Leu Thr Leu Ala Glu 
    130                 135                 140                 


Ile Asn Glu Tyr Leu Met Gly Lys Phe Pro Phe Phe Arg Gly Ser Tyr 
145                 150                 155                 160 


Thr Gly Trp Arg Asn Ser Val Arg His Asn Leu Ser Leu Asn Asp Cys 
                165                 170                 175     


Phe Val Lys Val Leu Arg Asp Pro Ser Arg Pro Trp Gly Lys Asp Asn 
            180                 185                 190         


Tyr Trp Met Leu Asn Pro Asn Ser Glu Tyr Thr Phe Ala Asp Gly Val 
        195                 200                 205             


Phe Arg Arg Arg Arg Lys Arg Leu Ser His Arg Ala Pro Val Pro Ala 
    210                 215                 220                 


Pro Gly Leu Arg Pro Glu Glu Ala Pro Gly Leu Pro Ala Ala Pro Pro 
225                 230                 235                 240 


Pro Ala Pro Ala Ala Pro Ala Ser Pro Arg Met Arg Ser Pro Ala Arg 
                245                 250                 255     


Gln Glu Glu Arg Ala Ser Pro Ala Gly Lys Phe Ser Ser Ser Phe Ala 
            260                 265                 270         


Ile Asp Ser Ile Leu Arg Lys Pro Phe Arg Ser Arg Arg Leu Arg Asp 
        275                 280                 285             


Thr Ala Pro Gly Thr Thr Leu Gln Trp Gly Ala Ala Pro Cys Pro Pro 
    290                 295                 300                 


Leu Pro Ala Phe Pro Ala Leu Leu Pro Ala Ala Pro Cys Arg Ala Leu 
305                 310                 315                 320 


Leu Pro Leu Cys Ala Tyr Gly Ala Gly Glu Pro Ala Arg Leu Gly Ala 
                325                 330                 335     


Arg Glu Ala Glu Val Pro Pro Thr Ala Pro Pro Leu Leu Leu Ala Pro 
            340                 345                 350         


Leu Pro Ala Ala Ala Pro Ala Lys Pro Leu Arg Gly Pro Ala Ala Gly 
        355                 360                 365             


Gly Ala His Leu Tyr Cys Pro Leu Arg Leu Pro Ala Ala Leu Gln Ala 
    370                 375                 380                 


Ala Ser Val Arg Arg Pro Gly Pro His Leu Pro Tyr Pro Val Glu Thr 
385                 390                 395                 400 


Leu Leu Ala 
            


<210>  4165
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXR1__Homo_sapiens__NP_859072

<400>  4165

Met Gly Asn Glu Leu Phe Leu Ala Phe Thr Thr Ser His Leu Pro Leu 
1               5                   10                  15      


Ala Glu Gln Lys Leu Ala Arg Tyr Lys Leu Arg Ile Val Lys Pro Pro 
            20                  25                  30          


Lys Leu Pro Leu Glu Lys Lys Pro Asn Pro Asp Lys Asp Gly Pro Asp 
        35                  40                  45              


Tyr Glu Pro Asn Leu Trp Met Trp Val Asn Pro Asn Ile Val Tyr Pro 
    50                  55                  60                  


Pro Gly Lys Leu Glu Val Ser Gly Arg Arg Lys Arg Glu Asp Leu Thr 
65                  70                  75                  80  


Ser Thr Leu Pro Ser Ser Gln Pro Pro Gln Lys Glu Glu Asp Ala Ser 
                85                  90                  95      


Cys Ser Glu Ala Ala Gly Val Glu Ser Leu Ser Gln Ser Ser Ser Lys 
            100                 105                 110         


Arg Ser Pro Pro Arg Lys Arg Phe Ala Phe Ser Pro Ser Thr Trp Glu 
        115                 120                 125             


Leu Thr Glu Glu Glu Glu Ala Glu Asp Gln Glu Asp Ser Ser Ser Met 
    130                 135                 140                 


Ala Leu Pro Ser Pro His Lys Arg Ala Pro Leu Gln Ser Arg Arg Leu 
145                 150                 155                 160 


Arg Gln Ala Ser Ser Gln Ala Gly Arg Leu Trp Ser Arg Pro Pro Leu 
                165                 170                 175     


Asn Tyr Phe His Leu Ile Ala Leu Ala Leu Arg Asn Ser Ser Pro Cys 
            180                 185                 190         


Gly Leu Asn Val Gln Gln Ile Tyr Ser Phe Thr Arg Lys His Phe Pro 
        195                 200                 205             


Phe Phe Arg Thr Ala Pro Glu Gly Trp Lys Asn Thr Val Arg His Asn 
    210                 215                 220                 


Leu Cys Phe Arg Asp Ser Phe Glu Lys Val Pro Val Ser Met Gln Gly 
225                 230                 235                 240 


Gly Ala Ser Thr Arg Pro Arg Ser Cys Leu Trp Lys Leu Thr Glu Glu 
                245                 250                 255     


Gly His Arg Arg Phe Ala Glu Glu Ala Arg Ala Leu Ala Ser Thr Arg 
            260                 265                 270         


Leu Glu Ser Ile Gln Gln Cys Met Ser Gln Pro Asp Val Met Pro Phe 
        275                 280                 285             


Leu Phe Asp Leu 
    290         


<210>  4166
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXR2__Homo_sapiens__NP_940853

<400>  4166

Met Asp Leu Lys Leu Lys Asp Cys Glu Phe Trp Tyr Ser Leu His Gly 
1               5                   10                  15      


Gln Val Pro Gly Leu Leu Asp Trp Asp Met Arg Asn Glu Leu Phe Leu 
            20                  25                  30          


Pro Cys Thr Thr Asp Gln Cys Ser Leu Ala Glu Gln Ile Leu Ala Lys 
        35                  40                  45              


Tyr Arg Val Gly Val Met Lys Pro Pro Glu Met Pro Gln Lys Arg Arg 
    50                  55                  60                  


Pro Ser Pro Asp Gly Asp Gly Pro Pro Cys Glu Pro Asn Leu Trp Met 
65                  70                  75                  80  


Trp Val Asp Pro Asn Ile Leu Cys Pro Leu Gly Ser Gln Glu Ala Pro 
                85                  90                  95      


Lys Pro Ser Gly Lys Glu Asp Leu Thr Asn Ile Ser Pro Phe Pro Gln 
            100                 105                 110         


Pro Pro Gln Lys Asp Glu Gly Ser Asn Cys Ser Glu Asp Lys Val Val 
        115                 120                 125             


Glu Ser Leu Pro Ser Ser Ser Ser Glu Gln Ser Pro Leu Gln Lys Gln 
    130                 135                 140                 


Gly Ile His Ser Pro Ser Asp Phe Glu Leu Thr Glu Glu Glu Ala Glu 
145                 150                 155                 160 


Glu Pro Asp Asp Asn Ser Leu Gln Ser Pro Glu Met Lys Cys Tyr Gln 
                165                 170                 175     


Ser Gln Lys Leu Trp Gln Ile Asn Asn Gln Glu Lys Ser Trp Gln Arg 
            180                 185                 190         


Pro Pro Leu Asn Cys Ser His Leu Ile Ala Leu Ala Leu Arg Asn Asn 
        195                 200                 205             


Pro His Cys Gly Leu Ser Val Gln Glu Ile Tyr Asn Phe Thr Arg Gln 
    210                 215                 220                 


His Phe Pro Phe Phe Trp Thr Ala Pro Asp Gly Trp Lys Ser Thr Ile 
225                 230                 235                 240 


His Tyr Asn Leu Cys Phe Leu Asp Ser Phe Glu Lys Val Pro Asp Ser 
                245                 250                 255     


Leu Lys Asp Glu Asp Asn Ala Arg Pro Arg Ser Cys Leu Trp Lys Leu 
            260                 265                 270         


Thr Lys Glu Gly His Arg Arg Phe Trp Glu Glu Thr Arg Val Leu Ala 
        275                 280                 285             


Phe Ala Gln Arg Glu Arg Ile Gln Glu Cys Met Ser Gln Pro Glu Leu 
    290                 295                 300                 


Leu Thr Ser Leu Phe Asp Leu 
305                 310     


<210>  4167
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXRED1__Homo_sapiens__NP_060017

<400>  4167

Met Ile Arg Arg Val Leu Pro His Gly Met Gly Arg Gly Leu Leu Thr 
1               5                   10                  15      


Arg Arg Pro Gly Thr Arg Arg Gly Gly Phe Ser Leu Asp Trp Asp Gly 
            20                  25                  30          


Lys Val Ser Glu Ile Lys Lys Lys Ile Lys Ser Ile Leu Pro Gly Arg 
        35                  40                  45              


Ser Cys Asp Leu Leu Gln Asp Thr Ser His Leu Pro Pro Glu His Ser 
    50                  55                  60                  


Asp Val Val Ile Val Gly Gly Gly Val Leu Gly Leu Ser Val Ala Tyr 
65                  70                  75                  80  


Trp Leu Lys Lys Leu Glu Ser Arg Arg Gly Ala Ile Arg Val Leu Val 
                85                  90                  95      


Val Glu Arg Asp His Thr Tyr Ser Gln Ala Ser Thr Gly Leu Ser Val 
            100                 105                 110         


Gly Gly Ile Cys Gln Gln Phe Ser Leu Pro Glu Asn Ile Gln Leu Ser 
        115                 120                 125             


Leu Phe Ser Ala Ser Phe Leu Arg Asn Ile Asn Glu Tyr Leu Ala Val 
    130                 135                 140                 


Val Asp Ala Pro Pro Leu Asp Leu Arg Phe Asn Pro Ser Gly Tyr Leu 
145                 150                 155                 160 


Leu Leu Ala Ser Glu Lys Asp Ala Ala Ala Met Glu Ser Asn Val Lys 
                165                 170                 175     


Val Gln Arg Gln Glu Gly Ala Lys Val Ser Leu Met Ser Pro Asp Gln 
            180                 185                 190         


Leu Arg Asn Lys Phe Pro Trp Ile Asn Thr Glu Gly Val Ala Leu Ala 
        195                 200                 205             


Ser Tyr Gly Met Glu Asp Glu Gly Trp Phe Asp Pro Trp Cys Leu Leu 
    210                 215                 220                 


Gln Gly Leu Arg Arg Lys Val Gln Ser Leu Gly Val Leu Phe Cys Gln 
225                 230                 235                 240 


Gly Glu Val Thr Arg Phe Val Ser Ser Ser Gln Arg Met Leu Thr Thr 
                245                 250                 255     


Asp Asp Lys Ala Val Val Leu Lys Arg Ile His Glu Val His Val Lys 
            260                 265                 270         


Met Asp Arg Ser Leu Glu Tyr Gln Pro Val Glu Cys Ala Ile Val Ile 
        275                 280                 285             


Asn Ala Ala Gly Ala Trp Ser Ala Gln Ile Ala Ala Leu Ala Gly Val 
    290                 295                 300                 


Gly Glu Gly Pro Pro Gly Thr Leu Gln Gly Thr Lys Leu Pro Val Glu 
305                 310                 315                 320 


Pro Arg Lys Arg Tyr Val Tyr Val Trp His Cys Pro Gln Gly Pro Gly 
                325                 330                 335     


Leu Glu Thr Pro Leu Val Ala Asp Thr Ser Gly Ala Tyr Phe Arg Arg 
            340                 345                 350         


Glu Gly Leu Gly Ser Asn Tyr Leu Gly Gly Arg Ser Pro Thr Glu Gln 
        355                 360                 365             


Glu Glu Pro Asp Pro Ala Asn Leu Glu Val Asp His Asp Phe Phe Gln 
    370                 375                 380                 


Asp Lys Val Trp Pro His Leu Ala Leu Arg Val Pro Ala Phe Glu Thr 
385                 390                 395                 400 


Leu Lys Val Gln Ser Ala Trp Ala Gly Tyr Tyr Asp Tyr Asn Thr Phe 
                405                 410                 415     


Asp Gln Asn Gly Val Val Gly Pro His Pro Leu Val Val Asn Met Tyr 
            420                 425                 430         


Phe Ala Thr Gly Phe Ser Gly His Gly Leu Gln Gln Ala Pro Gly Ile 
        435                 440                 445             


Gly Arg Ala Val Ala Glu Met Val Leu Lys Gly Arg Phe Gln Thr Ile 
    450                 455                 460                 


Asp Leu Ser Pro Phe Leu Phe Thr Arg Phe Tyr Leu Gly Glu Lys Ile 
465                 470                 475                 480 


Gln Glu Asn Asn Ile Ile 
                485     


<210>  4168
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FPGS__Homo_sapiens__NP_001275732

<400>  4168

Met Ser Arg Ala Arg Ser His Leu Arg Ala Ala Leu Phe Leu Ala Ala 
1               5                   10                  15      


Ala Ser Ala Arg Gly Ile Thr Thr Gln Val Ala Ala Arg Arg Gly Leu 
            20                  25                  30          


Ser Ala Trp Pro Val Pro Gln Glu Pro Ser Met Glu Tyr Gln Asp Ala 
        35                  40                  45              


Val Arg Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln 
    50                  55                  60                  


Val Lys Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu 
65                  70                  75                  80  


Leu Tyr Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu 
                85                  90                  95      


Asn Ile Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala 
            100                 105                 110         


Phe Thr Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe 
        115                 120                 125             


Ser Ser Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly 
    130                 135                 140                 


Gln Pro Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr 
145                 150                 155                 160 


His Arg Leu Glu Glu Thr Lys Val Asp Leu Ala Val Val Glu Val Gly 
                165                 170                 175     


Ile Gly Gly Ala Tyr Asp Cys Thr Asn Ile Ile Arg Lys Pro Val Val 
            180                 185                 190         


Cys Gly Val Ser Ser Leu Gly Ile Asp His Thr Ser Leu Leu Gly Asp 
        195                 200                 205             


Thr Val Glu Lys Ile Ala Trp Gln Lys Gly Gly Ile Phe Lys Gln Gly 
    210                 215                 220                 


Val Pro Ala Phe Thr Val Leu Gln Pro Glu Gly Pro Leu Ala Val Leu 
225                 230                 235                 240 


Arg Asp Arg Ala Gln Gln Ile Ser Cys Pro Leu Tyr Leu Cys Pro Met 
                245                 250                 255     


Leu Glu Ala Leu Glu Glu Gly Gly Pro Pro Leu Thr Leu Gly Leu Glu 
            260                 265                 270         


Gly Glu His Gln Arg Ser Asn Ala Ala Leu Ala Leu Gln Leu Ala His 
        275                 280                 285             


Cys Trp Leu Gln Arg Gln Asp Arg His Gly Ala Gly Glu Pro Lys Ala 
    290                 295                 300                 


Ser Arg Pro Gly Leu Leu Trp Gln Leu Pro Leu Ala Pro Val Phe Gln 
305                 310                 315                 320 


Pro Thr Ser His Met Arg Leu Gly Leu Arg Asn Thr Glu Trp Pro Gly 
                325                 330                 335     


Arg Thr Gln Val Leu Arg Arg Gly Pro Leu Thr Trp Tyr Leu Asp Gly 
            340                 345                 350         


Ala His Thr Ala Ser Ser Ala Gln Ala Cys Val Arg Trp Phe Arg Gln 
        355                 360                 365             


Ala Leu Gln Gly Arg Glu Arg Pro Ser Gly Gly Pro Glu Val Arg Val 
    370                 375                 380                 


Leu Leu Phe Asn Ala Thr Gly Asp Arg Asp Pro Ala Ala Leu Leu Lys 
385                 390                 395                 400 


Leu Leu Gln Pro Cys Gln Phe Asp Tyr Ala Val Phe Cys Pro Asn Leu 
                405                 410                 415     


Thr Glu Val Ser Ser Thr Gly Asn Ala Asp Gln Gln Asn Phe Thr Val 
            420                 425                 430         


Thr Leu Asp Gln Val Leu Leu Arg Cys Leu Glu His Gln Gln His Trp 
        435                 440                 445             


Asn His Leu Asp Glu Glu Gln Ala Ser Pro Asp Leu Trp Ser Ala Pro 
    450                 455                 460                 


Ser Pro Glu Pro Gly Gly Ser Ala Ser Leu Leu Leu Ala Pro His Pro 
465                 470                 475                 480 


Pro His Thr Cys Ser Ala Ser Ser Leu Val Phe Ser Cys Ile Ser His 
                485                 490                 495     


Ala Leu Gln Trp Ile Ser Gln Gly Arg Asp Pro Ile Phe Gln Pro Pro 
            500                 505                 510         


Ser Pro Pro Lys Gly Leu Leu Thr His Pro Val Ala His Ser Gly Ala 
        515                 520                 525             


Ser Ile Leu Arg Glu Ala Ala Ala Ile His Val Leu Val Thr Gly Ser 
    530                 535                 540                 


Leu His Leu Val Gly Gly Val Leu Lys Leu Leu Glu Pro Ala Leu Ser 
545                 550                 555                 560 


Gln 
    


<210>  4169
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FPR1__Homo_sapiens__NP_001180235

<400>  4169

Met Glu Thr Asn Ser Ser Leu Pro Thr Asn Ile Ser Gly Gly Thr Pro 
1               5                   10                  15      


Ala Val Ser Ala Gly Tyr Leu Phe Leu Asp Ile Ile Thr Tyr Leu Val 
            20                  25                  30          


Phe Ala Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr His Thr Val Thr Thr Ile Ser Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Val Ala Asp Phe Cys Phe Thr Ser Thr Leu Pro Phe 
65                  70                  75                  80  


Phe Met Val Arg Lys Ala Met Gly Gly His Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Phe Val Phe Thr Ile Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Ala Leu Ile Ala Leu Asp Arg Cys Val Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Thr Gln Asn His Arg Thr Val Ser Leu Ala Lys Lys 
    130                 135                 140                 


Val Ile Ile Gly Pro Trp Val Met Ala Leu Leu Leu Thr Leu Pro Val 
145                 150                 155                 160 


Ile Ile Arg Val Thr Thr Val Pro Gly Lys Thr Gly Thr Val Ala Cys 
                165                 170                 175     


Thr Phe Asn Phe Ser Pro Trp Thr Asn Asp Pro Lys Glu Arg Ile Asn 
            180                 185                 190         


Val Ala Val Ala Met Leu Thr Val Arg Gly Ile Ile Arg Phe Ile Ile 
        195                 200                 205             


Gly Phe Ser Ala Pro Met Ser Ile Val Ala Val Ser Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Thr Lys Ile His Lys Gln Gly Leu Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Ser Phe Val Ala Ala Ala Phe Phe Leu Cys Trp Ser Pro 
                245                 250                 255     


Tyr Gln Val Val Ala Leu Ile Ala Thr Val Arg Ile Arg Glu Leu Leu 
            260                 265                 270         


Gln Gly Met Tyr Lys Glu Ile Gly Ile Ala Val Asp Val Thr Ser Ala 
        275                 280                 285             


Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe Met 
    290                 295                 300                 


Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ala Leu Pro Ala Ser Leu 
305                 310                 315                 320 


Glu Arg Ala Leu Thr Glu Asp Ser Thr Gln Thr Ser Asp Thr Ala Thr 
                325                 330                 335     


Asn Ser Thr Leu Pro Ser Ala Glu Val Glu Leu Gln Ala Lys 
            340                 345                 350 


<210>  4170
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FPR2__Homo_sapiens__XP_006723183

<400>  4170

Met Glu Thr Asn Phe Ser Thr Pro Leu Asn Glu Tyr Glu Glu Val Ser 
1               5                   10                  15      


Tyr Glu Ser Ala Gly Tyr Thr Val Leu Arg Ile Leu Pro Leu Val Val 
            20                  25                  30          


Leu Gly Val Thr Phe Val Leu Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr Arg Thr Val Thr Thr Ile Cys Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Leu Ala Asp Phe Ser Phe Thr Ala Thr Leu Pro Phe 
65                  70                  75                  80  


Leu Ile Val Ser Met Ala Met Gly Glu Lys Trp Pro Phe Gly Trp Phe 
                85                  90                  95      


Leu Cys Lys Leu Ile His Ile Val Val Asp Ile Asn Leu Phe Gly Ser 
            100                 105                 110         


Val Phe Leu Ile Gly Phe Ile Ala Leu Asp Arg Cys Ile Cys Val Leu 
        115                 120                 125             


His Pro Val Trp Ala Gln Asn His Arg Thr Val Ser Leu Ala Met Lys 
    130                 135                 140                 


Val Ile Val Gly Pro Trp Ile Leu Ala Leu Val Leu Thr Leu Pro Val 
145                 150                 155                 160 


Phe Leu Phe Leu Thr Thr Val Thr Ile Pro Asn Gly Asp Thr Tyr Cys 
                165                 170                 175     


Thr Phe Asn Phe Ala Ser Trp Gly Gly Thr Pro Glu Glu Arg Leu Lys 
            180                 185                 190         


Val Ala Ile Thr Met Leu Thr Ala Arg Gly Ile Ile Arg Phe Val Ile 
        195                 200                 205             


Gly Phe Ser Leu Pro Met Ser Ile Val Ala Ile Cys Tyr Gly Leu Ile 
    210                 215                 220                 


Ala Ala Lys Ile His Lys Lys Gly Met Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Leu Thr Ala Val Val Ala Ser Phe Phe Ile Cys Trp Phe Pro 
                245                 250                 255     


Phe Gln Leu Val Ala Leu Leu Gly Thr Val Trp Leu Lys Glu Met Leu 
            260                 265                 270         


Phe Tyr Gly Lys Tyr Lys Ile Ile Asp Ile Leu Val Asn Pro Thr Ser 
        275                 280                 285             


Ser Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Met Leu Tyr Val Phe 
    290                 295                 300                 


Val Gly Gln Asp Phe Arg Glu Arg Leu Ile His Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Leu Glu Arg Ala Leu Ser Glu Asp Ser Ala Pro Thr Asn Asp Thr Ala 
                325                 330                 335     


Ala Asn Ser Ala Ser Pro Pro Ala Glu Thr Glu Leu Gln Ala Met 
            340                 345                 350     


<210>  4171
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FPR3__Homo_sapiens__NP_002021

<400>  4171

Met Glu Thr Asn Phe Ser Ile Pro Leu Asn Glu Thr Glu Glu Val Leu 
1               5                   10                  15      


Pro Glu Pro Ala Gly His Thr Val Leu Trp Ile Phe Ser Leu Leu Val 
            20                  25                  30          


His Gly Val Thr Phe Val Phe Gly Val Leu Gly Asn Gly Leu Val Ile 
        35                  40                  45              


Trp Val Ala Gly Phe Arg Met Thr Arg Thr Val Asn Thr Ile Cys Tyr 
    50                  55                  60                  


Leu Asn Leu Ala Leu Ala Asp Phe Ser Phe Ser Ala Ile Leu Pro Phe 
65                  70                  75                  80  


Arg Met Val Ser Val Ala Met Arg Glu Lys Trp Pro Phe Gly Ser Phe 
                85                  90                  95      


Leu Cys Lys Leu Val His Val Met Ile Asp Ile Asn Leu Phe Val Ser 
            100                 105                 110         


Val Tyr Leu Ile Thr Ile Ile Ala Leu Asp Arg Cys Ile Cys Val Leu 
        115                 120                 125             


His Pro Ala Trp Ala Gln Asn His Arg Thr Met Ser Leu Ala Lys Arg 
    130                 135                 140                 


Val Met Thr Gly Leu Trp Ile Phe Thr Ile Val Leu Thr Leu Pro Asn 
145                 150                 155                 160 


Phe Ile Phe Trp Thr Thr Ile Ser Thr Thr Asn Gly Asp Thr Tyr Cys 
                165                 170                 175     


Ile Phe Asn Phe Ala Phe Trp Gly Asp Thr Ala Val Glu Arg Leu Asn 
            180                 185                 190         


Val Phe Ile Thr Met Ala Lys Val Phe Leu Ile Leu His Phe Ile Ile 
        195                 200                 205             


Gly Phe Ser Val Pro Met Ser Ile Ile Thr Val Cys Tyr Gly Ile Ile 
    210                 215                 220                 


Ala Ala Lys Ile His Arg Asn His Met Ile Lys Ser Ser Arg Pro Leu 
225                 230                 235                 240 


Arg Val Phe Ala Ala Val Val Ala Ser Phe Phe Ile Cys Trp Phe Pro 
                245                 250                 255     


Tyr Glu Leu Ile Gly Ile Leu Met Ala Val Trp Leu Lys Glu Met Leu 
            260                 265                 270         


Leu Asn Gly Lys Tyr Lys Ile Ile Leu Val Leu Ile Asn Pro Thr Ser 
        275                 280                 285             


Ser Leu Ala Phe Phe Asn Ser Cys Leu Asn Pro Ile Leu Tyr Val Phe 
    290                 295                 300                 


Met Gly Arg Asn Phe Gln Glu Arg Leu Ile Arg Ser Leu Pro Thr Ser 
305                 310                 315                 320 


Leu Glu Arg Ala Leu Thr Glu Val Pro Asp Ser Ala Gln Thr Ser Asn 
                325                 330                 335     


Thr Asp Thr Thr Ser Ala Ser Pro Pro Glu Glu Thr Glu Leu Gln Ala 
            340                 345                 350         


Met 
    


<210>  4172
<211>  1976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRAS1__Homo_sapiens__NP_001159605

<400>  4172

Met Gly Val Leu Lys Val Trp Leu Gly Leu Ala Leu Ala Leu Ala Glu 
1               5                   10                  15      


Phe Ala Val Leu Pro His His Ser Glu Gly Ala Cys Val Tyr Gln Asp 
            20                  25                  30          


Ser Leu Leu Ala Asp Ala Thr Ile Trp Lys Pro Asp Ser Cys Gln Ser 
        35                  40                  45              


Cys Arg Cys His Gly Asp Ile Val Ile Cys Lys Pro Ala Val Cys Arg 
    50                  55                  60                  


Asn Pro Gln Cys Ala Phe Glu Lys Gly Glu Val Leu Gln Ile Ala Ala 
65                  70                  75                  80  


Asn Gln Cys Cys Pro Glu Cys Val Leu Arg Thr Pro Gly Ser Cys His 
                85                  90                  95      


His Glu Lys Lys Ile His Glu His Gly Thr Glu Trp Ala Ser Ser Pro 
            100                 105                 110         


Cys Ser Val Cys Ser Cys Asn His Gly Glu Val Arg Cys Thr Pro Gln 
        115                 120                 125             


Pro Cys Pro Pro Leu Ser Cys Gly His Gln Glu Leu Ala Phe Ile Pro 
    130                 135                 140                 


Glu Gly Ser Cys Cys Pro Val Cys Val Gly Leu Gly Lys Pro Cys Ser 
145                 150                 155                 160 


Tyr Glu Gly His Val Phe Gln Asp Gly Glu Asp Trp Arg Leu Ser Arg 
                165                 170                 175     


Cys Ala Lys Cys Leu Cys Arg Asn Gly Val Ala Gln Cys Phe Thr Ala 
            180                 185                 190         


Gln Cys Gln Pro Leu Phe Cys Asn Gln Asp Glu Thr Val Val Arg Val 
        195                 200                 205             


Pro Gly Lys Cys Cys Pro Gln Cys Ser Ala Arg Ser Cys Ser Ala Ala 
    210                 215                 220                 


Gly Gln Val Tyr Glu His Gly Glu Gln Trp Ser Glu Asn Ala Cys Thr 
225                 230                 235                 240 


Thr Cys Ile Cys Asp Arg Gly Glu Val Arg Cys His Lys Gln Ala Cys 
                245                 250                 255     


Leu Pro Leu Arg Cys Gly Lys Gly Gln Ser Arg Ala Arg Arg His Gly 
            260                 265                 270         


Gln Cys Cys Glu Glu Cys Val Ser Pro Ala Gly Ser Cys Ser Tyr Asp 
        275                 280                 285             


Gly Val Val Arg Tyr Gln Asp Glu Met Trp Lys Gly Ser Ala Cys Glu 
    290                 295                 300                 


Phe Cys Met Cys Asp His Gly Gln Val Thr Cys Gln Thr Gly Glu Cys 
305                 310                 315                 320 


Ala Lys Val Glu Cys Ala Arg Asp Glu Glu Leu Ile His Leu Asp Gly 
                325                 330                 335     


Lys Cys Cys Pro Glu Cys Ile Ser Arg Asn Gly Tyr Cys Val Tyr Glu 
            340                 345                 350         


Glu Thr Gly Glu Phe Met Ser Ser Asn Ala Ser Glu Val Lys Arg Ile 
        355                 360                 365             


Pro Glu Gly Glu Lys Trp Glu Asp Gly Pro Cys Lys Val Cys Glu Cys 
    370                 375                 380                 


Arg Gly Ala Gln Val Thr Cys Tyr Glu Pro Ser Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Val Gly Thr Leu Ala Leu Glu Val Lys Gly Gln Cys Cys Pro Asp Cys 
                405                 410                 415     


Thr Ser Val His Cys His Pro Asp Cys Leu Thr Cys Ser Gln Ser Pro 
            420                 425                 430         


Asp His Cys Asp Leu Cys Gln Asp Pro Thr Lys Leu Leu Gln Asn Gly 
        435                 440                 445             


Trp Cys Val His Ser Cys Gly Leu Gly Phe Tyr Gln Ala Gly Ser Leu 
    450                 455                 460                 


Cys Leu Ala Cys Gln Pro Gln Cys Ser Thr Cys Thr Ser Gly Leu Glu 
465                 470                 475                 480 


Cys Ser Ser Cys Gln Pro Pro Leu Leu Met Arg His Gly Gln Cys Val 
                485                 490                 495     


Pro Thr Cys Gly Asp Gly Phe Tyr Gln Asp Arg His Ser Cys Ala Val 
            500                 505                 510         


Cys His Glu Ser Cys Ala Gly Cys Trp Gly Pro Thr Glu Lys His Cys 
        515                 520                 525             


Leu Ala Cys Arg Asp Pro Leu His Val Leu Arg Asp Gly Gly Cys Glu 
    530                 535                 540                 


Ser Ser Cys Gly Lys Gly Phe Tyr Asn Arg Gln Gly Thr Cys Ser Ala 
545                 550                 555                 560 


Cys Asp Gln Ser Cys Asp Ser Cys Gly Pro Ser Ser Pro Arg Cys Leu 
                565                 570                 575     


Thr Cys Thr Glu Lys Thr Val Leu His Asp Gly Lys Cys Met Ser Glu 
            580                 585                 590         


Cys Pro Gly Gly Tyr Tyr Ala Asp Ala Thr Gly Arg Cys Lys Val Cys 
        595                 600                 605             


His Asn Ser Cys Ala Ser Cys Ser Gly Pro Thr Pro Ser His Cys Thr 
    610                 615                 620                 


Ala Cys Ser Pro Pro Lys Ala Leu Arg Gln Gly His Cys Leu Pro Arg 
625                 630                 635                 640 


Cys Gly Glu Gly Phe Tyr Ser Asp His Gly Val Cys Lys Ala Cys His 
                645                 650                 655     


Ser Ser Cys Leu Ala Cys Met Gly Pro Ala Pro Ser His Cys Thr Gly 
            660                 665                 670         


Cys Lys Lys Pro Glu Glu Gly Leu Gln Val Glu Gln Leu Ser Asp Val 
        675                 680                 685             


Gly Ile Pro Ser Gly Glu Cys Leu Ala Gln Cys Arg Ala His Phe Tyr 
    690                 695                 700                 


Leu Glu Ser Thr Gly Ile Cys Glu Ala Cys His Gln Ser Cys Phe Arg 
705                 710                 715                 720 


Cys Ala Gly Lys Ser Pro His Asn Cys Thr Asp Cys Gly Pro Ser His 
                725                 730                 735     


Val Leu Leu Asp Gly Gln Cys Leu Ser Gln Cys Pro Asp Gly Tyr Phe 
            740                 745                 750         


His Gln Glu Gly Ser Cys Thr Glu Cys His Pro Thr Cys Arg Gln Cys 
        755                 760                 765             


His Gly Pro Leu Glu Ser Asp Cys Ile Ser Cys Tyr Pro His Ile Ser 
    770                 775                 780                 


Leu Thr Asn Gly Asn Cys Arg Thr Ser Cys Arg Glu Glu Gln Phe Leu 
785                 790                 795                 800 


Asn Leu Val Gly Tyr Cys Ala Asp Cys His His Leu Cys Gln His Cys 
                805                 810                 815     


Ala Ala Asp Leu His Asn Thr Gly Ser Ile Cys Leu Arg Cys Gln Asn 
            820                 825                 830         


Ala His Tyr Leu Leu Leu Gly Asp His Cys Val Pro Asp Cys Pro Ser 
        835                 840                 845             


Gly Tyr Tyr Ala Glu Arg Gly Ala Cys Lys Lys Cys His Ser Ser Cys 
    850                 855                 860                 


Arg Thr Cys Gln Gly Arg Gly Pro Phe Ser Cys Ser Ser Cys Asp Thr 
865                 870                 875                 880 


Asn Leu Val Leu Ser His Thr Gly Thr Cys Ser Thr Thr Cys Phe Pro 
                885                 890                 895     


Gly His Tyr Leu Asp Asp Asn His Val Cys Gln Pro Cys Asn Thr His 
            900                 905                 910         


Cys Gly Ser Cys Asp Ser Gln Ala Ser Cys Thr Ser Cys Arg Asp Pro 
        915                 920                 925             


Asn Lys Val Leu Leu Phe Gly Glu Cys Gln Tyr Glu Ser Cys Ala Pro 
    930                 935                 940                 


Gln Tyr Tyr Leu Asp Phe Ser Thr Asn Thr Cys Lys Glu Cys Asp Trp 
945                 950                 955                 960 


Ser Cys Ser Ala Cys Ser Gly Pro Leu Lys Thr Asp Cys Leu Gln Cys 
                965                 970                 975     


Met Asp Gly Tyr Val Leu Gln Asp Gly Ala Cys Val Glu Gln Cys Leu 
            980                 985                 990         


Ser Ser Phe Tyr Gln Asp Ser Gly  Leu Cys Lys Asn Cys  Asp Ser Tyr 
        995                 1000                 1005             


Cys Leu  Gln Cys Gln Gly Pro  His Glu Cys Thr Arg  Cys Lys Gly 
    1010                 1015                 1020             


Pro Phe  Leu Leu Leu Glu Ala  Gln Cys Val Gln Glu  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  Phe Ala Asp His Ala  Lys His Lys Cys Thr  Ala Cys Pro 
    1040                 1045                 1050             


Gln Gly  Cys Leu Gln Cys Ser  His Arg Asp Arg Cys  His Leu Cys 
    1055                 1060                 1065             


Asp His  Gly Phe Phe Leu Lys  Ser Gly Leu Cys Val  Tyr Asn Cys 
    1070                 1075                 1080             


Val Pro  Gly Phe Ser Val His  Thr Ser Asn Glu Thr  Cys Ser Gly 
    1085                 1090                 1095             


Lys Ile  His Thr Pro Ser Leu  His Val Asn Gly Ser  Leu Ile Leu 
    1100                 1105                 1110             


Pro Ile  Gly Ser Ile Lys Pro  Leu Asp Phe Ser Leu  Leu Asn Val 
    1115                 1120                 1125             


Gln Asp  Gln Glu Gly Arg Val  Glu Asp Leu Leu Phe  His Val Val 
    1130                 1135                 1140             


Ser Thr  Pro Thr Asn Gly Gln  Leu Val Leu Ser Arg  Asn Gly Lys 
    1145                 1150                 1155             


Glu Val  Gln Leu Asp Lys Ala  Gly Arg Phe Ser Trp  Lys Asp Val 
    1160                 1165                 1170             


Asn Glu  Lys Lys Val Arg Phe  Val His Ser Lys Glu  Lys Leu Arg 
    1175                 1180                 1185             


Lys Gly  Tyr Leu Phe Leu Lys  Ile Ser Asp Gln Gln  Phe Phe Ser 
    1190                 1195                 1200             


Glu Pro  Gln Leu Ile Asn Ile  Gln Ala Phe Ser Thr  Gln Ala Pro 
    1205                 1210                 1215             


Tyr Val  Leu Arg Asn Glu Val  Leu His Ile Ser Arg  Gly Glu Arg 
    1220                 1225                 1230             


Ala Thr  Ile Thr Thr Gln Met  Leu Asp Ile Arg Asp  Asp Asp Asn 
    1235                 1240                 1245             


Pro Gln  Asp Val Val Ile Glu  Ile Ile Asp Pro Pro  Leu His Gly 
    1250                 1255                 1260             


Gln Leu  Leu Gln Thr Leu Gln  Ser Pro Ala Thr Pro  Ile Tyr Gln 
    1265                 1270                 1275             


Phe Gln  Leu Asp Glu Leu Ser  Arg Gly Leu Leu His  Tyr Ala His 
    1280                 1285                 1290             


Asp Gly  Ser Asp Ser Thr Ser  Asp Val Ala Val Leu  Gln Ala Asn 
    1295                 1300                 1305             


Asp Gly  His Ser Phe His Asn  Ile Leu Phe Gln Val  Lys Thr Val 
    1310                 1315                 1320             


Pro Gln  Asn Asp Arg Gly Leu  Gln Leu Val Ala Asn  Ser Met Val 
    1325                 1330                 1335             


Trp Val  Pro Glu Gly Gly Met  Leu Gln Ile Thr Asn  Arg Ile Leu 
    1340                 1345                 1350             


Gln Ala  Glu Ala Pro Gly Ala  Ser Ala Glu Glu Ile  Ile Tyr Lys 
    1355                 1360                 1365             


Ile Thr  Gln Asp Tyr Pro Gln  Phe Gly Glu Val Val  Leu Leu Val 
    1370                 1375                 1380             


Asn Met  Pro Ala Asp Ser Pro  Ala Asp Glu Gly Gln  His Leu Pro 
    1385                 1390                 1395             


Asp Gly  Arg Thr Ala Thr Pro  Thr Ser Thr Phe Thr  Gln Gln Asp 
    1400                 1405                 1410             


Ile Asn  Glu Gly Ile Val Trp  Tyr Arg His Ser Gly  Ala Pro Ala 
    1415                 1420                 1425             


Gln Ser  Asp Ser Phe Arg Phe  Glu Val Ser Ser Ala  Ser Asn Ala 
    1430                 1435                 1440             


Gln Thr  Arg Leu Glu Ser His  Met Phe Asn Ile Ala  Ile Leu Pro 
    1445                 1450                 1455             


Gln Thr  Pro Glu Ala Pro Lys  Val Ser Leu Glu Ala  Ser Leu His 
    1460                 1465                 1470             


Met Thr  Ala Arg Glu Asp Gly  Leu Thr Val Ile Gln  Pro His Ser 
    1475                 1480                 1485             


Leu Ser  Phe Ile Asn Ser Glu  Lys Pro Ser Gly Lys  Ile Val Tyr 
    1490                 1495                 1500             


Asn Ile  Thr Leu Pro Leu His  Pro Asn Gln Gly Ile  Ile Glu His 
    1505                 1510                 1515             


Arg Asp  His Pro His Ser Pro  Ile Arg Tyr Phe Thr  Gln Glu Asp 
    1520                 1525                 1530             


Ile Asn  Gln Gly Lys Val Met  Tyr Arg Pro Pro Pro  Ala Ala Pro 
    1535                 1540                 1545             


His Leu  Gln Glu Leu Met Ala  Phe Ser Phe Ala Gly  Leu Pro Glu 
    1550                 1555                 1560             


Ser Val  Lys Phe His Phe Thr  Val Ser Asp Gly Glu  His Thr Ser 
    1565                 1570                 1575             


Pro Glu  Met Val Leu Thr Ile  His Leu Leu Pro Ser  Asp Gln Gln 
    1580                 1585                 1590             


Leu Pro  Val Phe Gln Val Thr  Ala Pro Arg Leu Ala  Val Ser Pro 
    1595                 1600                 1605             


Gly Gly  Ser Thr Ser Val Gly  Leu Gln Val Val Val  Arg Asp Ala 
    1610                 1615                 1620             


Glu Thr  Ala Pro Lys Glu Leu  Phe Phe Glu Leu Arg  Arg Pro Pro 
    1625                 1630                 1635             


Gln His  Gly Val Leu Leu Lys  His Thr Ala Glu Phe  Arg Arg Pro 
    1640                 1645                 1650             


Met Ala  Thr Gly Asp Thr Phe  Thr Tyr Glu Asp Val  Glu Lys Asn 
    1655                 1660                 1665             


Ala Leu  Gln Tyr Ile His Asp  Gly Ser Ser Thr Arg  Glu Asp Ser 
    1670                 1675                 1680             


Met Glu  Ile Ser Val Thr Asp  Gly Leu Thr Val Thr  Met Leu Glu 
    1685                 1690                 1695             


Val Arg  Val Glu Val Ser Leu  Ser Glu Asp Arg Gly  Pro Arg Leu 
    1700                 1705                 1710             


Ala Ala  Gly Ser Ser Leu Ser  Ile Thr Val Ala Ser  Lys Ser Thr 
    1715                 1720                 1725             


Ala Ile  Ile Thr Arg Ser His  Leu Ala Tyr Val Asp  Asp Ser Ser 
    1730                 1735                 1740             


Pro Asp  Pro Glu Ile Trp Ile  Gln Leu Asn Tyr Leu  Pro Ser Tyr 
    1745                 1750                 1755             


Gly Thr  Leu Leu Arg Ile Ser  Gly Ser Glu Val Glu  Glu Leu Ser 
    1760                 1765                 1770             


Glu Val  Ser Asn Phe Thr Met  Glu Asp Ile Asn Asn  Lys Lys Ile 
    1775                 1780                 1785             


Arg Tyr  Ser Ala Val Phe Glu  Thr Asp Gly His Leu  Val Thr Asp 
    1790                 1795                 1800             


Ser Phe  Tyr Phe Ser Val Ser  Asp Met Asp His Asn  His Leu Asp 
    1805                 1810                 1815             


Asn Gln  Ile Phe Thr Ile Met  Ile Thr Pro Ala Glu  Asn Pro Pro 
    1820                 1825                 1830             


Pro Val  Ile Ala Phe Ala Asp  Leu Ile Thr Val Asp  Glu Gly Gly 
    1835                 1840                 1845             


Arg Ala  Pro Leu Ser Phe His  His Phe Phe Ala Thr  Asp Asp Asp 
    1850                 1855                 1860             


Asp Asn  Leu Gln Arg Asp Ala  Ile Ile Lys Leu Ser  Ala Leu Pro 
    1865                 1870                 1875             


Lys Tyr  Gly Cys Ile Glu Asn  Thr Gly Thr Gly Asp  Arg Phe Gly 
    1880                 1885                 1890             


Pro Glu  Thr Ala Ser Asp Leu  Glu Ala Ser Phe Pro  Ile Gln Asp 
    1895                 1900                 1905             


Val Leu  Glu Asn Tyr Ile Tyr  Tyr Phe Gln Ser Val  His Glu Ser 
    1910                 1915                 1920             


Ile Glu  Pro Thr His Asp Ile  Phe Ser Phe Tyr Val  Ser Asp Gly 
    1925                 1930                 1935             


Thr Ser  Arg Ser Glu Ile His  Ser Ile Asn Ile Thr  Ile Glu Val 
    1940                 1945                 1950             


Lys Thr  Leu Glu Val Gly Lys  Val Glu Pro Leu Thr  Thr Ile Phe 
    1955                 1960                 1965             


His Thr  Ile Arg Glu Leu Ser  Leu 
    1970                 1975     


<210>  4173
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRAT1__Homo_sapiens__NP_005470

<400>  4173

Met Pro Cys Arg Arg Glu Glu Glu Glu Glu Ala Gly Glu Glu Ala Glu 
1               5                   10                  15      


Gly Glu Glu Glu Glu Glu Asp Ser Phe Leu Leu Leu Gln Gln Ser Val 
            20                  25                  30          


Ala Leu Gly Ser Ser Gly Glu Val Asp Arg Leu Val Ala Gln Ile Gly 
        35                  40                  45              


Glu Thr Leu Gln Leu Asp Ala Ala Gln His Ser Pro Ala Ser Pro Cys 
    50                  55                  60                  


Gly Pro Pro Gly Ala Pro Leu Arg Ala Pro Gly Pro Leu Ala Ala Ala 
65                  70                  75                  80  


Val Pro Ala Asp Lys Ala Arg Ser Pro Ala Val Pro Leu Leu Leu Pro 
                85                  90                  95      


Pro Ala Leu Ala Glu Thr Val Gly Pro Ala Pro Pro Gly Val Leu Arg 
            100                 105                 110         


Cys Ala Leu Gly Asp Arg Gly Arg Val Arg Gly Arg Ala Ala Pro Tyr 
        115                 120                 125             


Cys Val Ala Glu Leu Ala Thr Gly Pro Ser Ala Leu Ser Pro Leu Pro 
    130                 135                 140                 


Pro Gln Ala Asp Leu Asp Gly Pro Pro Gly Ala Gly Lys Gln Gly Ile 
145                 150                 155                 160 


Pro Gln Pro Leu Ser Gly Pro Cys Arg Arg Gly Trp Leu Arg Gly Ala 
                165                 170                 175     


Ala Ala Ser Arg Arg Leu Gln Gln Arg Arg Gly Ser Gln Pro Glu Thr 
            180                 185                 190         


Arg Thr Gly Asp Asp Asp Pro His Arg Leu Leu Gln Gln Leu Val Leu 
        195                 200                 205             


Ser Gly Asn Leu Ile Lys Glu Ala Val Arg Arg Leu His Ser Arg Arg 
    210                 215                 220                 


Leu Gln Leu Arg Ala Lys Leu Pro Gln Arg Pro Leu Leu Gly Pro Leu 
225                 230                 235                 240 


Ser Ala Pro Val His Glu Pro Pro Ser Pro Arg Ser Pro Arg Ala Ala 
                245                 250                 255     


Cys Ser Asp Pro Gly Ala Ser Gly Arg Ala Gln Leu Arg Thr Gly Asp 
            260                 265                 270         


Gly Val Leu Val Pro Gly Ser 
        275                 


<210>  4174
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRAT2__Homo_sapiens__NP_036215

<400>  4174

Met Pro Cys Arg Arg Glu Glu Glu Glu Glu Ala Gly Glu Glu Ala Glu 
1               5                   10                  15      


Gly Glu Glu Glu Glu Asp Asp Ser Phe Leu Leu Leu Gln Gln Ser Val 
            20                  25                  30          


Thr Leu Gly Ser Ser Gly Glu Val Asp Arg Leu Val Ala Gln Ile Gly 
        35                  40                  45              


Glu Thr Leu Gln Leu Asp Ala Ala Gln Asp Ser Pro Ala Ser Pro Cys 
    50                  55                  60                  


Ala Pro Pro Gly Val Pro Leu Arg Ala Pro Gly Pro Leu Ala Ala Ala 
65                  70                  75                  80  


Val Pro Ala Asp Lys Ala Arg Pro Pro Ala Val Pro Leu Leu Leu Pro 
                85                  90                  95      


Pro Ala Ser Ala Glu Thr Val Gly Pro Ala Pro Ser Gly Ala Leu Arg 
            100                 105                 110         


Cys Ala Leu Gly Asp Arg Gly Arg Val Arg Gly Arg Ala Ala Pro Tyr 
        115                 120                 125             


Cys Val Ala Glu Val Ala Ala Gly Pro Ser Ala Leu Pro Gly Pro Cys 
    130                 135                 140                 


Arg Arg Gly Trp Leu Arg Asp Ala Val Thr Ser Arg Arg Leu Gln Gln 
145                 150                 155                 160 


Arg Arg Trp Thr Gln Ala Gly Ala Arg Ala Gly Asp Asp Asp Pro His 
                165                 170                 175     


Arg Leu Leu Gln Gln Leu Val Leu Ser Gly Asn Leu Ile Lys Glu Ala 
            180                 185                 190         


Val Arg Arg Leu Gln Arg Ala Val Ala Ala Val Ala Ala Thr Gly Pro 
        195                 200                 205             


Ala Ser Ala Pro Gly Pro Gly Gly Gly Arg Ser Gly Pro Asp Arg Ile 
    210                 215                 220                 


Ala Leu Gln Pro Ser Gly Ser Leu Leu 
225                 230             


<210>  4175
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FREM1__Homo_sapiens__XP_006716792

<400>  4175

Met Val Thr Gln Glu Ser Met Leu Lys Ala Ala Leu Pro Leu Phe Thr 
1               5                   10                  15      


Arg Phe Ile Ile Ser Asn Gly Leu Arg Thr Glu His Gly Val Phe Glu 
            20                  25                  30          


Ile Thr Leu Glu Thr Val Asp Arg Ala Leu Pro Val Val Thr Arg Asn 
        35                  40                  45              


Lys Gly Leu Arg Leu Ala Gln Gly Ala Val Gly Leu Leu Ser Pro Asp 
    50                  55                  60                  


Leu Leu Gln Leu Thr Asp Pro Asp Thr Pro Ala Glu Asn Leu Thr Phe 
65                  70                  75                  80  


Leu Leu Val Gln Leu Pro Gln His Gly Gln Leu Tyr Leu Trp Gly Thr 
                85                  90                  95      


Gly Leu Leu Gln His Asn Phe Thr Gln Gln Asp Val Asp Ser Lys Asn 
            100                 105                 110         


Val Ala Tyr Arg His Ser Gly Gly Asp Ser Gln Thr Asp Cys Phe Thr 
        115                 120                 125             


Phe Met Ala Thr Asp Gly Thr Asn Gln Gly Phe Ile Val Asn Gly Arg 
    130                 135                 140                 


Val Trp Glu Glu Pro Val Leu Phe Thr Ile Gln Val Asp Gln Leu Asp 
145                 150                 155                 160 


Lys Thr Ala Pro Arg Ile Thr Leu Leu His Ser Pro Ser Gln Val Gly 
                165                 170                 175     


Leu Leu Lys Asn Gly Cys Tyr Gly Ile Tyr Ile Thr Ser Arg Val Leu 
            180                 185                 190         


Lys Ala Ser Asp Pro Asp Thr Glu Asp Asp Gln Ile Ile Phe Lys Ile 
        195                 200                 205             


Leu Gln Gly Pro Lys His Gly His Leu Glu Asn Thr Thr Thr Gly Glu 
    210                 215                 220                 


Phe Ile His Glu Lys Phe Ser Gln Lys Asp Leu Asn Ser Lys Thr Ile 
225                 230                 235                 240 


Leu Tyr Ile Ile Asn Pro Ser Leu Glu Val Asn Ser Asp Thr Val Glu 
                245                 250                 255     


Phe Gln Ile Met Asp Pro Thr Gly Asn Ser Ala Thr Pro Gln Ile Leu 
            260                 265                 270         


Glu Leu Lys Trp Ser His Ile Glu Trp Ser Gln Thr Glu Tyr Glu Val 
        275                 280                 285             


Cys Glu Asn Val Gly Leu Leu Pro Leu Glu Ile Ile Arg Arg Gly Tyr 
    290                 295                 300                 


Ser Met Asp Ser Ala Phe Val Gly Ile Lys Val Asn Gln Val Ser Ala 
305                 310                 315                 320 


Ala Val Gly Lys Asp Phe Thr Val Ile Pro Ser Lys Leu Ile Gln Phe 
                325                 330                 335     


Asp Pro Gly Met Ser Thr Lys Met Trp Asn Ile Ala Ile Thr Tyr Asp 
            340                 345                 350         


Gly Leu Glu Glu Asp Asp Glu Val Phe Glu Val Ile Leu Asn Ser Pro 
        355                 360                 365             


Val Asn Ala Val Leu Gly Thr Lys Thr Lys Ala Ala Val Lys Ile Leu 
    370                 375                 380                 


Asp Ser Lys Gly Gly Gln Cys His Pro Ser Tyr Ser Ser Asn Gln Ser 
385                 390                 395                 400 


Lys His Ser Thr Trp Glu Lys Gly Ile Trp His Leu Leu Pro Pro Gly 
                405                 410                 415     


Ser Ser Ser Ser Thr Thr Ser Gly Ser Phe His Leu Glu Arg Arg Pro 
            420                 425                 430         


Leu Pro Ser Ser Met Gln Leu Ala Val Ile Arg Gly Asp Thr Leu Arg 
        435                 440                 445             


Gly Phe Asp Ser Thr Asp Leu Ser Gln Arg Lys Leu Arg Thr Arg Gly 
    450                 455                 460                 


Asn Gly Lys Thr Val Arg Pro Ser Ser Val Tyr Arg Asn Gly Thr Asp 
465                 470                 475                 480 


Ile Ile Tyr Asn Tyr His Gly Ile Val Ser Leu Lys Leu Glu Asp Asp 
                485                 490                 495     


Ser Phe Pro Thr His Lys Arg Lys Ala Lys Val Ser Ile Ile Ser Gln 
            500                 505                 510         


Pro Gln Lys Thr Ile Lys Val Ala Glu Leu Pro Gln Ala Asp Lys Val 
        515                 520                 525             


Glu Ser Thr Thr Asp Ser His Phe Pro Arg Gln Asp Gln Leu Pro Ser 
    530                 535                 540                 


Phe Pro Lys Asn Cys Thr Leu Glu Leu Lys Gly Leu Phe His Phe Glu 
545                 550                 555                 560 


Glu Gly Ile Gln Lys Leu Tyr Gln Cys Asn Gly Ile Ala Trp Lys Ala 
                565                 570                 575     


Trp Ser Pro Gln Thr Lys Asp Val Glu Asp Lys Ser Cys Pro Ala Gly 
            580                 585                 590         


Trp His Gln His Ser Gly Tyr Cys His Ile Leu Ile Thr Glu Gln Lys 
        595                 600                 605             


Gly Thr Trp Asn Ala Ala Ala Gln Ala Cys Arg Glu Gln Tyr Leu Gly 
    610                 615                 620                 


Asn Leu Val Thr Val Phe Ser Arg Gln His Met Arg Trp Leu Trp Asp 
625                 630                 635                 640 


Ile Gly Gly Arg Lys Ser Phe Trp Ile Gly Leu Asn Asp Gln Val His 
                645                 650                 655     


Ala Gly His Trp Glu Trp Ile Gly Gly Glu Pro Val Ala Phe Thr Asn 
            660                 665                 670         


Gly Arg Arg Gly Pro Ser Gln Arg Ser Lys Leu Gly Lys Ser Cys Val 
        675                 680                 685             


Leu Val Gln Arg Gln Gly Lys Trp Gln Thr Lys Asp Cys Arg Arg Ala 
    690                 695                 700                 


Lys Pro His Asn Tyr Val Cys Ser Arg Lys Leu 
705                 710                 715 


<210>  4176
<211>  3169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FREM2__Homo_sapiens__NP_997244

<400>  4176

Met His Ser Ala Gly Thr Pro Gly Leu Ser Ser Arg Arg Thr Gly Asn 
1               5                   10                  15      


Ser Thr Ser Phe Gln Pro Gly Pro Pro Pro Pro Pro Arg Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Ser Leu Val Ser Arg Val Pro Ala Gln Pro 
        35                  40                  45              


Ala Ala Phe Gly Arg Ala Leu Leu Ser Pro Gly Leu Ala Gly Ala Ala 
    50                  55                  60                  


Gly Val Pro Ala Glu Glu Ala Ile Val Leu Ala Asn Arg Gly Leu Arg 
65                  70                  75                  80  


Val Pro Phe Gly Arg Glu Val Trp Leu Asp Pro Leu His Asp Leu Val 
                85                  90                  95      


Leu Gln Val Gln Pro Gly Asp Arg Cys Ala Val Ser Val Leu Asp Asn 
            100                 105                 110         


Asp Ala Leu Ala Gln Arg Pro Gly Arg Leu Ser Pro Lys Arg Phe Pro 
        115                 120                 125             


Cys Asp Phe Gly Pro Gly Glu Val Arg Tyr Ser His Leu Gly Ala Arg 
    130                 135                 140                 


Ser Pro Ser Arg Asp Arg Val Arg Leu Gln Leu Arg Tyr Asp Ala Pro 
145                 150                 155                 160 


Gly Gly Ala Val Val Leu Pro Leu Val Leu Glu Val Glu Val Val Phe 
                165                 170                 175     


Thr Gln Leu Glu Val Val Thr Arg Asn Leu Pro Leu Val Val Glu Glu 
            180                 185                 190         


Leu Leu Gly Thr Ser Asn Ala Leu Asp Ala Arg Ser Leu Glu Phe Ala 
        195                 200                 205             


Phe Gln Pro Glu Thr Glu Glu Cys Arg Val Gly Ile Leu Ser Gly Leu 
    210                 215                 220                 


Gly Ala Leu Pro Arg Tyr Gly Glu Leu Leu His Tyr Pro Gln Val Pro 
225                 230                 235                 240 


Gly Gly Ala Arg Glu Gly Gly Ala Pro Glu Thr Leu Leu Met Asp Cys 
                245                 250                 255     


Lys Ala Phe Gln Glu Leu Gly Val Arg Tyr Arg His Thr Ala Ala Ser 
            260                 265                 270         


Arg Ser Pro Asn Arg Asp Trp Ile Pro Met Val Val Glu Leu Arg Ser 
        275                 280                 285             


Arg Gly Ala Pro Val Gly Ser Pro Ala Leu Lys Arg Glu His Phe Gln 
    290                 295                 300                 


Val Leu Val Arg Ile Arg Gly Gly Ala Glu Asn Thr Ala Pro Lys Pro 
305                 310                 315                 320 


Ser Phe Val Ala Met Met Met Met Glu Val Asp Gln Phe Val Leu Thr 
                325                 330                 335     


Ala Leu Thr Pro Asp Met Leu Ala Ala Glu Asp Ala Glu Ser Pro Ser 
            340                 345                 350         


Asp Leu Leu Ile Phe Asn Leu Thr Ser Pro Phe Gln Pro Gly Gln Gly 
        355                 360                 365             


Tyr Leu Val Ser Thr Asp Asp Arg Ser Leu Pro Leu Ser Ser Phe Thr 
    370                 375                 380                 


Gln Arg Asp Leu Arg Leu Leu Lys Ile Ala Tyr Gln Pro Pro Ser Glu 
385                 390                 395                 400 


Asp Ser Asp Gln Glu Arg Leu Phe Glu Leu Glu Leu Glu Val Val Asp 
                405                 410                 415     


Leu Glu Gly Ala Ala Ser Asp Pro Phe Ala Phe Met Val Val Val Lys 
            420                 425                 430         


Pro Met Asn Thr Met Ala Pro Val Val Thr Arg Asn Thr Gly Leu Ile 
        435                 440                 445             


Leu Tyr Glu Gly Gln Ser Arg Pro Leu Thr Gly Pro Ala Gly Ser Gly 
    450                 455                 460                 


Pro Gln Asn Leu Val Ile Ser Asp Glu Asp Asp Leu Glu Ala Val Arg 
465                 470                 475                 480 


Leu Glu Val Val Ala Gly Leu Arg His Gly His Leu Val Ile Leu Gly 
                485                 490                 495     


Ala Ser Ser Gly Ser Ser Ala Pro Lys Ser Phe Thr Val Ala Glu Leu 
            500                 505                 510         


Ala Ala Gly Gln Val Val Tyr Gln His Asp Asp Arg Asp Gly Ser Leu 
        515                 520                 525             


Ser Asp Asn Leu Val Leu Arg Met Val Asp Gly Gly Gly Arg His Gln 
    530                 535                 540                 


Val Gln Phe Leu Phe Pro Ile Thr Leu Val Pro Val Asp Asp Gln Pro 
545                 550                 555                 560 


Pro Val Leu Asn Ala Asn Thr Gly Leu Thr Leu Ala Glu Gly Glu Thr 
                565                 570                 575     


Val Pro Ile Leu Pro Leu Ser Leu Ser Ala Thr Asp Met Asp Ser Asp 
            580                 585                 590         


Asp Ser Leu Leu Leu Phe Val Leu Glu Ser Pro Phe Leu Thr Thr Gly 
        595                 600                 605             


His Leu Leu Leu Arg Gln Thr His Pro Pro His Glu Lys Gln Glu Leu 
    610                 615                 620                 


Leu Arg Gly Leu Trp Arg Lys Glu Gly Ala Phe Tyr Glu Arg Thr Val 
625                 630                 635                 640 


Thr Glu Trp Gln Gln Gln Asp Ile Thr Glu Gly Arg Leu Phe Tyr Arg 
                645                 650                 655     


His Ser Gly Pro His Ser Pro Gly Pro Val Thr Asp Gln Phe Thr Phe 
            660                 665                 670         


Arg Val Gln Asp Asn His Asp Pro Pro Asn Gln Ser Gly Leu Gln Arg 
        675                 680                 685             


Phe Val Ile Arg Ile His Pro Val Asp Arg Leu Pro Pro Glu Leu Gly 
    690                 695                 700                 


Ser Gly Cys Pro Leu Arg Met Val Val Gln Glu Ser Gln Leu Thr Pro 
705                 710                 715                 720 


Leu Arg Lys Lys Trp Leu Arg Tyr Thr Asp Leu Asp Thr Asp Asp Arg 
                725                 730                 735     


Glu Leu Arg Tyr Thr Val Thr Gln Pro Pro Thr Asp Thr Asp Glu Asn 
            740                 745                 750         


His Leu Pro Ala Pro Leu Gly Thr Leu Val Leu Thr Asp Asn Pro Ser 
        755                 760                 765             


Val Val Val Thr His Phe Thr Gln Ala Gln Ile Asn His His Lys Ile 
    770                 775                 780                 


Ala Tyr Arg Pro Pro Gly Gln Glu Leu Gly Val Ala Thr Arg Val Ala 
785                 790                 795                 800 


Gln Phe Gln Phe Gln Val Glu Asp Arg Ala Gly Asn Val Ala Pro Gly 
                805                 810                 815     


Thr Phe Thr Leu Tyr Leu His Pro Val Asp Asn Gln Pro Pro Glu Ile 
            820                 825                 830         


Leu Asn Thr Gly Phe Thr Ile Gln Glu Lys Gly His His Ile Leu Ser 
        835                 840                 845             


Glu Thr Glu Leu His Val Asn Asp Val Asp Thr Asp Val Ala His Ile 
    850                 855                 860                 


Ser Phe Thr Leu Thr Gln Ala Pro Lys His Gly His Met Arg Val Ser 
865                 870                 875                 880 


Gly Gln Ile Leu His Val Gly Gly Leu Phe His Leu Glu Asp Ile Lys 
                885                 890                 895     


Gln Gly Arg Val Ser Tyr Ala His Asn Gly Asp Lys Ser Leu Thr Asp 
            900                 905                 910         


Ser Cys Ser Leu Glu Val Ser Asp Arg His His Val Val Pro Ile Thr 
        915                 920                 925             


Leu Arg Val Asn Val Arg Pro Val Asp Asp Glu Val Pro Ile Leu Ser 
    930                 935                 940                 


His Pro Thr Gly Thr Leu Glu Ser Tyr Leu Asp Val Leu Glu Asn Gly 
945                 950                 955                 960 


Ala Thr Glu Ile Thr Ala Asn Val Ile Lys Gly Thr Asn Glu Glu Thr 
                965                 970                 975     


Asp Asp Leu Met Leu Thr Phe Leu Leu Glu Asp Pro Pro Leu Tyr Gly 
            980                 985                 990         


Glu Ile Leu Val Asn Gly Ile Pro  Ala Glu Gln Phe Thr  Gln Arg Asp 
        995                 1000                 1005             


Ile Leu  Glu Gly Ser Val Val  Tyr Thr His Thr Ser  Gly Glu Ile 
    1010                 1015                 1020             


Gly Leu  Leu Pro Lys Ala Asp  Ser Phe Asn Leu Ser  Leu Ser Asp 
    1025                 1030                 1035             


Met Ser  Gln Glu Trp Arg Ile  Gly Gly Asn Thr Ile  Gln Gly Val 
    1040                 1045                 1050             


Thr Ile  Trp Val Thr Ile Leu  Pro Val Asp Ser Gln  Ala Pro Glu 
    1055                 1060                 1065             


Ile Phe  Val Gly Glu Gln Leu  Ile Val Met Glu Gly  Asp Lys Ser 
    1070                 1075                 1080             


Val Ile  Thr Ser Val His Ile  Ser Ala Glu Asp Val  Asp Ser Leu 
    1085                 1090                 1095             


Asn Asp  Asp Ile Leu Cys Thr  Ile Val Ile Gln Pro  Thr Ser Gly 
    1100                 1105                 1110             


Tyr Val  Glu Asn Ile Ser Pro  Ala Pro Gly Ser Glu  Lys Ser Arg 
    1115                 1120                 1125             


Ala Gly  Ile Ala Ile Ser Ala  Phe Asn Leu Lys Asp  Leu Arg Gln 
    1130                 1135                 1140             


Gly His  Ile Asn Tyr Val Gln  Ser Val His Lys Gly  Val Glu Pro 
    1145                 1150                 1155             


Val Glu  Asp Arg Phe Val Phe  Arg Cys Ser Asp Gly  Ile Asn Phe 
    1160                 1165                 1170             


Ser Glu  Arg Gln Phe Phe Pro  Ile Val Ile Ile Pro  Thr Asn Asp 
    1175                 1180                 1185             


Glu Gln  Pro Glu Met Phe Met  Arg Glu Phe Met Val  Met Glu Gly 
    1190                 1195                 1200             


Met Ser  Leu Val Ile Asp Thr  Pro Ile Leu Asn Ala  Ala Asp Ala 
    1205                 1210                 1215             


Asp Val  Pro Leu Asp Asp Leu  Thr Phe Thr Ile Thr  Gln Phe Pro 
    1220                 1225                 1230             


Thr His  Gly His Ile Met Asn  Gln Leu Ile Asn Gly  Thr Val Leu 
    1235                 1240                 1245             


Val Glu  Ser Phe Thr Leu Asp  Gln Ile Ile Glu Ser  Ser Ser Ile 
    1250                 1255                 1260             


Ile Tyr  Glu His Asp Asp Ser  Glu Thr Gln Glu Asp  Ser Phe Val 
    1265                 1270                 1275             


Ile Lys  Leu Thr Asp Gly Lys  His Ser Val Glu Lys  Thr Val Leu 
    1280                 1285                 1290             


Ile Ile  Val Ile Pro Val Asp  Asp Glu Thr Pro Arg  Met Thr Ile 
    1295                 1300                 1305             


Asn Asn  Gly Leu Glu Ile Glu  Ile Gly Asp Thr Lys  Ile Ile Asn 
    1310                 1315                 1320             


Asn Lys  Ile Leu Met Ala Thr  Asp Leu Asp Ser Glu  Asp Lys Ser 
    1325                 1330                 1335             


Leu Val  Tyr Ile Ile Arg Tyr  Gly Pro Gly His Gly  Leu Leu Gln 
    1340                 1345                 1350             


Arg Arg  Lys Pro Thr Gly Ala  Phe Glu Asn Ile Thr  Leu Gly Met 
    1355                 1360                 1365             


Asn Phe  Thr Gln Asp Glu Val  Asp Arg Asn Leu Ile  Gln Tyr Val 
    1370                 1375                 1380             


His Leu  Gly Gln Glu Gly Ile  Arg Asp Leu Ile Lys  Phe Asp Val 
    1385                 1390                 1395             


Thr Asp  Gly Ile Asn Pro Leu  Ile Asp Arg Tyr Phe  Tyr Val Ser 
    1400                 1405                 1410             


Ile Gly  Ser Ile Asp Ile Val  Phe Pro Asp Val Ile  Ser Lys Gly 
    1415                 1420                 1425             


Val Ser  Leu Lys Glu Gly Gly  Lys Val Thr Leu Thr  Thr Asp Leu 
    1430                 1435                 1440             


Leu Ser  Thr Ser Asp Leu Asn  Ser Pro Asp Glu Asn  Leu Val Phe 
    1445                 1450                 1455             


Thr Ile  Thr Arg Ala Pro Met  Arg Gly His Leu Glu  Cys Thr Asp 
    1460                 1465                 1470             


Gln Pro  Gly Val Ser Ile Thr  Ser Phe Thr Gln Leu  Gln Leu Ala 
    1475                 1480                 1485             


Gly Asn  Lys Ile Tyr Tyr Ile  His Thr Ala Asp Asp  Glu Val Lys 
    1490                 1495                 1500             


Met Asp  Ser Phe Glu Phe Gln  Val Thr Asp Gly Arg  Asn Pro Val 
    1505                 1510                 1515             


Phe Arg  Thr Phe Arg Ile Ser  Ile Ser Asp Val Asp  Asn Lys Lys 
    1520                 1525                 1530             


Pro Val  Val Thr Ile His Lys  Leu Val Val Ser Glu  Ser Glu Asn 
    1535                 1540                 1545             


Lys Leu  Ile Thr Pro Phe Glu  Leu Thr Val Glu Asp  Arg Asp Thr 
    1550                 1555                 1560             


Pro Asp  Lys Leu Leu Lys Phe  Thr Ile Thr Gln Val  Pro Ile His 
    1565                 1570                 1575             


Gly His  Leu Leu Phe Asn Asn  Thr Arg Pro Val Met  Val Phe Thr 
    1580                 1585                 1590             


Lys Gln  Asp Leu Asn Glu Asn  Leu Ile Ser Tyr Lys  His Asp Gly 
    1595                 1600                 1605             


Thr Glu  Ser Ser Glu Asp Ser  Phe Ser Phe Thr Val  Thr Asp Gly 
    1610                 1615                 1620             


Thr His  Thr Asp Phe Tyr Val  Phe Pro Asp Thr Val  Phe Glu Thr 
    1625                 1630                 1635             


Arg Arg  Pro Gln Val Met Lys  Ile Gln Val Leu Ala  Val Asp Asn 
    1640                 1645                 1650             


Ser Val  Pro Gln Ile Ala Val  Asn Lys Gly Ala Ser  Thr Leu Arg 
    1655                 1660                 1665             


Thr Leu  Ala Thr Gly His Leu  Gly Phe Met Ile Thr  Ser Lys Ile 
    1670                 1675                 1680             


Leu Lys  Val Glu Asp Arg Asp  Ser Leu His Ile Ser  Leu Arg Phe 
    1685                 1690                 1695             


Ile Val  Thr Glu Ala Pro Gln  His Gly Tyr Leu Leu  Asn Leu Asp 
    1700                 1705                 1710             


Lys Gly  Asn His Ser Ile Thr  Gln Phe Thr Gln Ala  Asp Ile Asp 
    1715                 1720                 1725             


Asp Met  Lys Ile Cys Tyr Val  Leu Arg Glu Gly Ala  Asn Ala Thr 
    1730                 1735                 1740             


Ser Asp  Met Phe Tyr Phe Ala  Val Glu Asp Gly Gly  Gly Asn Lys 
    1745                 1750                 1755             


Leu Thr  Tyr Gln Asn Phe Arg  Leu Asn Trp Ala Trp  Ile Ser Phe 
    1760                 1765                 1770             


Glu Lys  Glu Tyr Tyr Leu Val  Asn Glu Asp Ser Lys  Phe Leu Asp 
    1775                 1780                 1785             


Val Val  Leu Lys Arg Arg Gly  Tyr Leu Gly Glu Thr  Ser Phe Ile 
    1790                 1795                 1800             


Ser Ile  Gly Thr Arg Asp Arg  Thr Ala Glu Lys Asp  Lys Asp Phe 
    1805                 1810                 1815             


Lys Gly  Lys Ala Gln Lys Gln  Val Gln Phe Asn Pro  Gly Gln Thr 
    1820                 1825                 1830             


Arg Ala  Thr Trp Arg Val Arg  Ile Leu Ser Asp Gly  Glu His Glu 
    1835                 1840                 1845             


Gln Ser  Glu Thr Phe Gln Val  Val Leu Ser Glu Pro  Val Leu Ala 
    1850                 1855                 1860             


Ala Leu  Glu Phe Pro Thr Val  Ala Thr Val Glu Ile  Val Asp Pro 
    1865                 1870                 1875             


Gly Asp  Glu Pro Thr Val Phe  Ile Pro Gln Ser Lys  Tyr Ser Val 
    1880                 1885                 1890             


Glu Glu  Asp Val Gly Glu Leu  Phe Ile Pro Ile Arg  Arg Ser Gly 
    1895                 1900                 1905             


Asp Val  Ser Gln Glu Leu Met  Val Val Cys Tyr Thr  Gln Gln Gly 
    1910                 1915                 1920             


Thr Ala  Thr Gly Thr Val Pro  Thr Ser Val Leu Ser  Tyr Ser Asp 
    1925                 1930                 1935             


Tyr Ile  Ser Arg Pro Glu Asp  His Thr Ser Val Val  Arg Phe Asp 
    1940                 1945                 1950             


Lys Asp  Glu Arg Glu Lys Leu  Cys Arg Ile Val Ile  Ile Asp Asp 
    1955                 1960                 1965             


Ser Leu  Tyr Glu Glu Glu Glu  Thr Phe His Val Leu  Leu Ser Met 
    1970                 1975                 1980             


Pro Met  Gly Gly Arg Ile Gly  Ser Glu Phe Pro Gly  Ala Gln Val 
    1985                 1990                 1995             


Thr Ile  Val Pro Asp Lys Asp  Asp Glu Pro Ile Phe  Tyr Phe Gly 
    2000                 2005                 2010             


Asp Val  Glu Tyr Ser Val Asp  Glu Ser Ala Gly Tyr  Val Glu Val 
    2015                 2020                 2025             


Gln Val  Trp Arg Thr Gly Thr  Asp Leu Ser Lys Ser  Ser Ser Val 
    2030                 2035                 2040             


Thr Val  Arg Ser Arg Lys Thr  Asp Pro Pro Ser Ala  Asp Ala Gly 
    2045                 2050                 2055             


Thr Asp  Tyr Val Gly Ile Ser  Arg Asn Leu Asp Phe  Ala Pro Gly 
    2060                 2065                 2070             


Val Asn  Met Gln Pro Val Arg  Val Val Ile Leu Asp  Asp Leu Gly 
    2075                 2080                 2085             


Gln Pro  Ala Leu Glu Gly Ile  Glu Lys Phe Glu Leu  Val Leu Arg 
    2090                 2095                 2100             


Met Pro  Met Asn Ala Ala Leu  Gly Glu Pro Ser Lys  Ala Thr Val 
    2105                 2110                 2115             


Ser Ile  Asn Asp Ser Val Ser  Asp Leu Pro Lys Met  Gln Phe Lys 
    2120                 2125                 2130             


Glu Arg  Ile Tyr Thr Gly Ser  Glu Ser Asp Gly Gln  Ile Val Thr 
    2135                 2140                 2145             


Met Ile  His Arg Thr Gly Asp  Val Gln Tyr Arg Ser  Ser Val Arg 
    2150                 2155                 2160             


Cys Tyr  Thr Arg Gln Gly Ser  Ala Gln Val Met Met  Asp Phe Glu 
    2165                 2170                 2175             


Glu Arg  Pro Asn Thr Asp Thr  Ser Ile Ile Thr Phe  Leu Pro Gly 
    2180                 2185                 2190             


Glu Thr  Glu Lys Pro Cys Ile  Leu Glu Leu Met Asp  Asp Val Leu 
    2195                 2200                 2205             


Tyr Glu  Glu Val Glu Glu Leu  Arg Leu Val Leu Gly  Thr Pro Gln 
    2210                 2215                 2220             


Ser Asn  Ser Pro Phe Gly Ala  Ala Val Gly Glu Gln  Asn Glu Thr 
    2225                 2230                 2235             


Leu Ile  Arg Ile Arg Asp Asp  Ala Asp Lys Thr Val  Ile Lys Phe 
    2240                 2245                 2250             


Gly Glu  Thr Lys Phe Ser Val  Thr Glu Pro Lys Glu  Pro Gly Glu 
    2255                 2260                 2265             


Ser Val  Val Ile Arg Ile Pro  Val Ile Arg Gln Gly  Asp Thr Ser 
    2270                 2275                 2280             


Lys Val  Ser Ile Val Arg Val  His Thr Lys Asp Gly  Ser Ala Thr 
    2285                 2290                 2295             


Ser Gly  Glu Asp Tyr His Pro  Val Ser Glu Glu Ile  Glu Phe Lys 
    2300                 2305                 2310             


Glu Gly  Glu Thr Gln His Val  Val Glu Ile Glu Val  Thr Phe Asp 
    2315                 2320                 2325             


Gly Val  Arg Glu Met Arg Glu  Ala Phe Thr Val His  Leu Lys Pro 
    2330                 2335                 2340             


Asp Glu  Asn Met Ile Ala Glu  Met Gln Leu Thr Lys  Ala Ile Val 
    2345                 2350                 2355             


Tyr Ile  Glu Glu Met Ser Ser  Met Ala Asp Val Thr  Phe Pro Ser 
    2360                 2365                 2370             


Val Pro  Gln Ile Val Ser Leu  Leu Met Tyr Asp Asp  Thr Ser Lys 
    2375                 2380                 2385             


Ala Lys  Glu Ser Ala Glu Pro  Met Ser Gly Tyr Pro  Val Ile Cys 
    2390                 2395                 2400             


Ile Thr  Ala Cys Asn Pro Lys  Tyr Ser Asp Tyr Asp  Lys Thr Gly 
    2405                 2410                 2415             


Ser Ile  Cys Ala Ser Glu Asn  Ile Asn Asp Thr Leu  Thr Arg Tyr 
    2420                 2425                 2430             


Arg Trp  Leu Ile Ser Ala Pro  Ala Gly Pro Asp Gly  Val Thr Ser 
    2435                 2440                 2445             


Pro Met  Arg Glu Val Asp Phe  Asp Thr Phe Phe Thr  Ser Ser Lys 
    2450                 2455                 2460             


Met Val  Thr Leu Asp Ser Ile  Tyr Phe Gln Pro Gly  Ser Arg Val 
    2465                 2470                 2475             


Gln Cys  Ala Ala Arg Ala Val  Asn Thr Asn Gly Asp  Glu Gly Leu 
    2480                 2485                 2490             


Glu Leu  Met Ser Pro Ile Val  Thr Ile Ser Arg Glu  Glu Gly Leu 
    2495                 2500                 2505             


Cys Gln  Pro Arg Val Pro Gly  Val Val Gly Ala Glu  Pro Phe Ser 
    2510                 2515                 2520             


Ala Lys  Leu Arg Tyr Thr Gly  Pro Glu Asp Ala Asp  Tyr Thr Asn 
    2525                 2530                 2535             


Leu Ile  Lys Leu Thr Val Thr  Met Pro His Ile Asp  Gly Met Leu 
    2540                 2545                 2550             


Pro Val  Ile Ser Thr Arg Glu  Leu Ser Asn Phe Glu  Leu Thr Leu 
    2555                 2560                 2565             


Ser Pro  Asp Gly Thr Arg Val  Gly Asn His Lys Cys  Ser Asn Leu 
    2570                 2575                 2580             


Leu Asp  Tyr Thr Glu Val Lys  Thr His Tyr Gly Phe  Leu Thr Asp 
    2585                 2590                 2595             


Ala Thr  Lys Asn Pro Glu Ile  Ile Gly Glu Thr Tyr  Pro Tyr Gln 
    2600                 2605                 2610             


Tyr Ser  Leu Ser Ile Arg Gly  Ser Thr Thr Leu Arg  Phe Tyr Arg 
    2615                 2620                 2625             


Asn Leu  Asn Leu Glu Ala Cys  Leu Trp Glu Phe Val  Ser Tyr Tyr 
    2630                 2635                 2640             


Asp Met  Ser Glu Leu Leu Ala  Asp Cys Gly Gly Thr  Ile Gly Thr 
    2645                 2650                 2655             


Asp Gly  Gln Val Leu Asn Leu  Val Gln Ser Tyr Val  Thr Leu Arg 
    2660                 2665                 2670             


Val Pro  Leu Tyr Val Ser Tyr  Val Phe His Ser Pro  Val Gly Val 
    2675                 2680                 2685             


Gly Gly  Trp Gln His Phe Asp  Leu Lys Ser Glu Leu  Arg Leu Thr 
    2690                 2695                 2700             


Phe Val  Tyr Asp Thr Ala Ile  Leu Trp Asn Asp Gly  Ile Gly Ser 
    2705                 2710                 2715             


Pro Pro  Glu Ala Glu Leu Gln  Gly Ser Leu Tyr Pro  Thr Ser Met 
    2720                 2725                 2730             


Arg Ile  Gly Asp Glu Gly Arg  Leu Ala Val His Phe  Lys Thr Glu 
    2735                 2740                 2745             


Ala Gln  Phe His Gly Leu Phe  Val Leu Ser His Pro  Ala Ser Phe 
    2750                 2755                 2760             


Thr Ser  Ser Val Ile Met Ser  Ala Asp His Pro Gly  Leu Thr Phe 
    2765                 2770                 2775             


Ser Leu  Arg Leu Ile Arg Ser  Glu Pro Thr Tyr Asn  Gln Pro Val 
    2780                 2785                 2790             


Gln Gln  Trp Ser Phe Val Ser  Asp Phe Ala Val Arg  Asp Tyr Ser 
    2795                 2800                 2805             


Gly Thr  Tyr Thr Val Lys Leu  Val Pro Cys Thr Ala  Pro Ser His 
    2810                 2815                 2820             


Gln Glu  Tyr Arg Leu Pro Val  Thr Cys Asn Pro Arg  Glu Pro Val 
    2825                 2830                 2835             


Thr Phe  Asp Leu Asp Ile Arg  Phe Gln Gln Val Ser  Asp Pro Val 
    2840                 2845                 2850             


Ala Ala  Glu Phe Ser Leu Asn  Thr Gln Met Tyr Leu  Leu Ser Lys 
    2855                 2860                 2865             


Lys Ser  Leu Trp Leu Ser Asp  Gly Ser Met Gly Phe  Gly Gln Glu 
    2870                 2875                 2880             


Ser Asp  Val Ala Phe Ala Glu  Gly Asp Ile Ile Tyr  Gly Arg Val 
    2885                 2890                 2895             


Met Val  Asp Pro Val Gln Asn  Leu Gly Asp Ser Phe  Tyr Cys Ser 
    2900                 2905                 2910             


Ile Glu  Lys Val Phe Leu Cys  Thr Gly Ala Asp Gly  Tyr Val Pro 
    2915                 2920                 2925             


Lys Tyr  Ser Pro Met Asn Ala  Glu Tyr Gly Cys Leu  Ala Asp Ser 
    2930                 2935                 2940             


Pro Ser  Leu Leu Tyr Arg Phe  Lys Ile Val Asp Lys  Ala Gln Pro 
    2945                 2950                 2955             


Glu Thr  Gln Ala Thr Ser Phe  Gly Asn Val Leu Phe  Asn Ala Lys 
    2960                 2965                 2970             


Leu Ala  Val Asp Asp Pro Glu  Ala Ile Leu Leu Val  Asn Gln Pro 
    2975                 2980                 2985             


Gly Ser  Asp Gly Phe Lys Val  Asp Ser Thr Pro Leu  Phe Gln Val 
    2990                 2995                 3000             


Ala Leu  Gly Arg Glu Trp Tyr  Ile His Thr Ile Tyr  Thr Val Arg 
    3005                 3010                 3015             


Ser Lys  Asp Asn Ala Asn Arg  Gly Ile Gly Lys Arg  Ser Val Glu 
    3020                 3025                 3030             


Tyr His  Ser Leu Val Ser Gln  Gly Lys Pro Gln Ser  Thr Thr Lys 
    3035                 3040                 3045             


Ser Arg  Lys Lys Arg Glu Ile  Arg Ser Thr Pro Ser  Leu Ala Trp 
    3050                 3055                 3060             


Glu Ile  Gly Ala Glu Asn Ser  Arg Gly Thr Asn Ile  Gln His Ile 
    3065                 3070                 3075             


Ala Leu  Asp Arg Thr Lys Arg  Gln Ile Pro His Gly  Arg Ala Pro 
    3080                 3085                 3090             


Pro Asp  Gly Ile Leu Pro Trp  Glu Leu Asn Ser Pro  Ser Ser Ala 
    3095                 3100                 3105             


Val Ser  Leu Val Thr Val Val  Gly Gly Thr Thr Val  Gly Leu Leu 
    3110                 3115                 3120             


Thr Ile  Cys Leu Thr Val Ile  Ala Val Leu Met Cys  Arg Gly Lys 
    3125                 3130                 3135             


Glu Ser  Phe Arg Gly Lys Asp  Ala Pro Lys Gly Ser  Ser Ser Ser 
    3140                 3145                 3150             


Glu Pro  Met Val Pro Pro Gln  Ser His His Asn Asp  Ser Ser Glu 
    3155                 3160                 3165             


Val 
    


<210>  4177
<211>  2139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FREM3__Homo_sapiens__NP_001161707

<400>  4177

Met Ala Gly Ala Ser Arg His Pro Thr Gly Thr Pro Arg Gln Leu Leu 
1               5                   10                  15      


Val Ala Leu Ala Cys Leu Leu Leu Ser Arg Pro Ala Leu Gln Gly Arg 
            20                  25                  30          


Ala Ser Ser Leu Gly Thr Glu Pro Asp Pro Ala Leu Tyr Leu Pro Ala 
        35                  40                  45              


Arg Gly Ala Leu Asp Gly Thr Arg Pro Asp Gly Pro Ser Val Leu Ile 
    50                  55                  60                  


Ala Asn Pro Gly Leu Arg Val Pro Leu Gly Arg Ser Leu Trp Leu Asp 
65                  70                  75                  80  


Pro Leu Arg Asp Leu Val Ile Gly Val Gln Pro Gly Asp Arg Cys Glu 
                85                  90                  95      


Val Thr Val Leu Asp Ala Leu Pro Arg Leu Lys Gly Ala Leu Ser Pro 
            100                 105                 110         


Arg Arg Phe Pro Cys Thr Phe Gly Pro Arg Gln Val Gln Tyr Thr His 
        115                 120                 125             


Phe Gly Ser His Ser Pro Gly Arg Ala Arg Val Leu Leu Gln Leu Arg 
    130                 135                 140                 


Tyr Asp Ala Pro Thr His Thr Leu Val Leu Pro Phe Thr Leu Ala Val 
145                 150                 155                 160 


Asp Leu Val Phe Ser Gln Leu Glu Leu Val Thr Arg Asn Arg Pro Leu 
                165                 170                 175     


Val Val Glu Lys Leu Arg Ser Trp Ser Arg Ala Ile Asp Arg Arg Val 
            180                 185                 190         


Leu Asp Phe Ala Ser Leu Lys Ser Gly Ala Thr Ala Thr Arg Arg Cys 
        195                 200                 205             


Arg Leu Thr Pro Leu Pro His Glu Asp Gly Pro Leu Pro Lys Tyr Gly 
    210                 215                 220                 


Arg Leu Val Asp Ala Val Gly Ala Pro Leu Pro Arg Gly Lys Gly Val 
225                 230                 235                 240 


Asp Cys Glu Ala Phe Leu Arg Ala Gly Val Arg Tyr Gln His Thr Ala 
                245                 250                 255     


Thr Ser Ser Pro Asn Arg Asp Tyr Val Pro Met Met Val Glu Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Gln Asp Ala Gly Ser Ala Gly Val Leu Val Arg Glu 
        275                 280                 285             


His Phe Gln Leu Leu Val Arg Ile Arg Gly Gly Ala Glu Asn Thr Pro 
    290                 295                 300                 


Pro Arg Pro Ser Phe Met Ala Thr Met Met Met Glu Val Asp Pro Leu 
305                 310                 315                 320 


Val Leu Thr Ala Leu Thr Pro Asp Ala Leu Ala Ala Glu Asp Val Glu 
                325                 330                 335     


Ser Asp Pro Gly Asp Leu Val Phe Asn Ile Leu Asn Ala Pro Thr His 
            340                 345                 350         


Pro Pro Gly His Pro Gly Gln Gln Gly Tyr Val Val Ser Thr Asp Asp 
        355                 360                 365             


Pro Leu Gly Leu Pro Val Ser Phe Phe Thr Gln Gln Glu Leu Arg Glu 
    370                 375                 380                 


Leu Lys Ile Ala Tyr Gln Pro Pro Ala Glu Asn Ser His Gly Glu Arg 
385                 390                 395                 400 


Leu Phe Gln Leu Glu Leu Glu Val Val Asp Gly Asp Gly Ala Ala Ser 
                405                 410                 415     


Asp Pro Phe Ala Phe Met Val Thr Val Lys Ser Met Asn Thr Leu Val 
            420                 425                 430         


Pro Val Ala Ser His Asn Arg Gly Leu Val Leu Phe Glu Gly Gln Ser 
        435                 440                 445             


Arg Pro Leu Ser Ser Thr His Ser Ile Pro Ile Ser Asp Lys Asp Asn 
    450                 455                 460                 


Leu Glu Glu Val Lys Met Ala Ala Val Arg Gly Leu Arg His Gly Gln 
465                 470                 475                 480 


Leu Val Val Phe Gly Ala Pro Ala Gly Cys Lys Tyr Phe Thr Pro Ala 
                485                 490                 495     


Asp Leu Ala Ala Gly Arg Val Val Tyr Gln His Asp Gly Ser Asn Thr 
            500                 505                 510         


Tyr Ser Asp Asn Ile Ile Phe Arg Met Glu Asp Gly His His Gln Val 
        515                 520                 525             


Asp Phe Leu Phe Pro Leu Thr Ile Leu Pro Val Asp Asp Glu Pro Pro 
    530                 535                 540                 


Met Val Asn Thr Asn Thr Gly Leu Ser Leu Thr Glu Gly Gln Val Val 
545                 550                 555                 560 


Gln Ile Ser Pro Phe Val Leu Ser Ala Thr Asp Ile Asp Ser Glu Asp 
                565                 570                 575     


Ser Thr Ile His Phe Val Leu Glu Asn Gln Pro Leu Lys Gly Asn Glu 
            580                 585                 590         


Glu Glu Pro Gln Trp Glu Leu Ala Pro Gly Ser Ser His Ser Gly His 
        595                 600                 605             


Tyr Leu Gly Asp Leu Leu Leu Gln Gln Ala Glu Leu Pro Leu Ser Thr 
    610                 615                 620                 


Glu Asp Glu Asp Trp His Tyr Met Glu Lys Glu Gly Leu Tyr Glu Lys 
625                 630                 635                 640 


Val Val Thr Glu Trp Leu Gln Arg Asp Ile Met Glu Gly Arg Leu Phe 
                645                 650                 655     


Tyr Arg His Leu Gly Pro His Ser Pro Gln Ser Val Met Val Gln Leu 
            660                 665                 670         


Ala Phe His Val Gln Asp Asp His Asp Pro Pro Asn Leu Ser Lys Gln 
        675                 680                 685             


His Ile Phe Thr Ile Lys Val Gln Pro Val Asp Ile Leu Ser Pro Gln 
    690                 695                 700                 


Leu Tyr Pro Gly Thr Thr Leu Glu Met Thr Val Gln Glu Tyr Gln Leu 
705                 710                 715                 720 


Thr His Phe Gln Lys Asn Phe Leu Arg Tyr Ile Asp Gln Asp Ser Asp 
                725                 730                 735     


Asp Gln Asn Leu Trp Tyr Thr Leu Leu Thr Leu Pro Thr Asp Thr Asp 
            740                 745                 750         


Gly Asn His Gln Val Arg Ala Gly Glu Ile Val Leu Thr Asp Ser Pro 
        755                 760                 765             


Asp Thr Leu Ile Met His Phe Thr Gln Ala Gln Val Asn Gln His Lys 
    770                 775                 780                 


Val Ala Tyr Gln Pro Pro Gln Lys Leu Gly Ile Ala Pro Arg Val Val 
785                 790                 795                 800 


Gln Phe Thr Tyr Gln Val Glu Asp Ala Ala Gly Asn Ser Val Pro Gly 
                805                 810                 815     


Thr Phe Thr Leu Phe Leu Gln Pro Val Asp Asn Gln Pro Pro Glu Val 
            820                 825                 830         


Thr Asn Arg Gly Phe Ala Ile Leu Glu Gly Gly Ser Phe Asn Leu Ser 
        835                 840                 845             


Ser Asn Glu Leu His Val Thr Asp Pro Asp Thr Asp Ile Asp Gln Ile 
    850                 855                 860                 


Val Phe Ile Leu Val Arg Gly Pro Gln His Gly His Leu Gln Tyr Phe 
865                 870                 875                 880 


Lys Arg Cys Met Val Pro Gly Glu Ser Phe Met Gln Ala Asp Val Ile 
                885                 890                 895     


Asn Gly Ser Val Ser Tyr Gln His Gly Arg Asp Gln Thr Thr Thr Ser 
            900                 905                 910         


Asp Thr Phe His Leu Glu Val Ser Asp Gly Val His His Ile Pro Ile 
        915                 920                 925             


Thr Ile Pro Ile Ser Val His Pro Asn Val Ala Asn Arg Ser Pro Arg 
    930                 935                 940                 


Ile Ser Leu Arg Ser Ser Ser Leu Leu Asp Val Ser Ile Asp Val Leu 
945                 950                 955                 960 


Glu Asn Lys Ala Thr Glu Ile Thr Met Gly Val Ile His Gly Lys Arg 
                965                 970                 975     


Lys Asp Val Gly Asp Leu Met Leu Ser Phe Ile Val Lys Asp Ser Pro 
            980                 985                 990         


Lys Leu Gly Thr Ile Leu Val Asn  Gly Leu Pro Thr Glu  Arg Phe Thr 
        995                 1000                 1005             


Gln Glu  Asp Leu Ile Asn Gly  Arg Val Ala Tyr Ala  His Thr Ala 
    1010                 1015                 1020             


Gly Glu  Val Gly Phe Gln Lys  Gln His Asp Ala Phe  Ser Leu Ile 
    1025                 1030                 1035             


Leu Ser  Lys Asp Ser Tyr Gln  Trp Val Val Gly Asn  Ser Ile Ile 
    1040                 1045                 1050             


Glu Lys  Val Gln Val Gln Val  Thr Val Leu Pro Val  Asp Asn Val 
    1055                 1060                 1065             


Gly Pro  Lys Val Phe Val Gly  Glu Ser Phe Ile Val  Tyr Glu Gly 
    1070                 1075                 1080             


Glu Lys  Asn Ser Leu Thr Leu  Gln His Leu His Val  Glu Asp Val 
    1085                 1090                 1095             


Asp Thr  His Gln Asp Glu Leu  Leu Cys Thr Val Thr  Ser Gln Pro 
    1100                 1105                 1110             


Ala Ser  Gly Tyr Leu Glu Lys  Ile Ala Ser Ala Pro  Gly Ser Lys 
    1115                 1120                 1125             


Met Ser  Gln Ser Gly Ser Pro  Ile Ser Ala Phe Ser  Leu Arg Asp 
    1130                 1135                 1140             


Ile Gln  Val Arg His Ile Asn  Tyr Val Gln Ser Ile  His Lys Gly 
    1145                 1150                 1155             


Val Glu  Pro Gln Glu Asp Gln  Phe Thr Phe Tyr Cys  Ser Asp Gly 
    1160                 1165                 1170             


Ile Asn  Phe Ser Pro Asn Val  Phe Phe Pro Ile Ile  Ile Leu Pro 
    1175                 1180                 1185             


Thr Asn  Asp Glu Gln Pro Lys  Leu Phe Ala His Glu  Phe Lys Val 
    1190                 1195                 1200             


Leu Glu  Gly Met Ser Leu Val  Ile Asp Thr Gln Leu  Leu Asn Gly 
    1205                 1210                 1215             


Ala Asp  Ala Asp Leu Pro Pro  Asn Glu Leu His Phe  Gln Leu Thr 
    1220                 1225                 1230             


Ala Leu  Pro Arg His Gly Arg  Ile Ile Gln Gln Leu  Ala Thr Gly 
    1235                 1240                 1245             


Ser Gln  Pro Ile His Ser Phe  Thr Leu Lys Glu Ile  Gln Glu Ala 
    1250                 1255                 1260             


Ser Thr  Ile Val Tyr Glu His  Asp Asp Ser Glu Thr  Lys Glu Asp 
    1265                 1270                 1275             


Ser Phe  Glu Val Trp Leu Ser  Asp Gly Lys His Thr  Thr His Arg 
    1280                 1285                 1290             


Lys Val  Pro Ile Val Val Thr  Leu Val Asp Asp Glu  Thr Pro His 
    1295                 1300                 1305             


Leu Thr  Val Asn Asn Gly Leu  Lys Val Glu Lys Gly  His Ser Glu 
    1310                 1315                 1320             


Ile Ile  Thr Asn Arg Ile Leu  Lys Ala Thr Asp Leu  Asp Ser Asp 
    1325                 1330                 1335             


Asp Lys  Ser Leu Ser Phe Val  Leu His Ser Gly Pro  Gln Gln Gly 
    1340                 1345                 1350             


Leu Leu  Gln Arg Leu Arg Lys  Pro Arg Gly Glu Val  Arg Asn Asn 
    1355                 1360                 1365             


Leu Thr  Leu Gly Met Asn Phe  Thr Gln Asp Glu Ile  Asn Arg Gly 
    1370                 1375                 1380             


Leu Ile  Cys Tyr Ile His Thr  Gly Gln Glu Gly Ile  Val Asp Ile 
    1385                 1390                 1395             


Ile Lys  Phe Asp Val Thr Asp  Gly Val Asn Thr Leu  Thr Asp His 
    1400                 1405                 1410             


Tyr Phe  Tyr Val Thr Ile Gly  Asn Leu Asp Ser Val  Phe Pro Glu 
    1415                 1420                 1425             


Val Ile  Ser Lys Arg Ile Thr  Leu Ile Glu Gly Ala  Arg Val Thr 
    1430                 1435                 1440             


Leu Thr  Asn Asn Leu Leu Thr  Asn Ser Asp Ile Asn  Ser Ser Asp 
    1445                 1450                 1455             


Glu His  His Phe Ser Ile Thr  Arg Ala Pro Ser Leu  Gly His Leu 
    1460                 1465                 1470             


Glu Ser  Ser Asp Tyr Ala Gly  Glu Pro Ile Ala Ser  Phe Thr Gln 
    1475                 1480                 1485             


Leu Gln  Leu Ala Ser Asn Lys  Ile Ser Tyr Val His  Thr Ser Asn 
    1490                 1495                 1500             


Asp Glu  Lys Lys Met Asp Ser  Phe Glu Phe Gln Val  Ile Gly Glu 
    1505                 1510                 1515             


Leu Tyr  Pro Val Phe Arg Thr  Phe Arg Ile Phe Ile  Thr Asp Val 
    1520                 1525                 1530             


Asp Asn  Lys Lys Pro Ile Leu  Thr Ile His Arg Leu  Thr Leu Gln 
    1535                 1540                 1545             


Lys Glu  Asp Ser Gln Leu Ile  Thr Leu Leu Glu Leu  Thr Val Glu 
    1550                 1555                 1560             


Asp Ser  Asp Thr Pro Asp Asp  Leu Ile Leu Phe Thr  Ile Thr Gln 
    1565                 1570                 1575             


Val Pro  Met His Gly Lys Ile  Leu Tyr Asn Gly Ser  Arg Pro Val 
    1580                 1585                 1590             


Thr Thr  Phe Thr Lys Gln Asp  Leu Asn Lys Asn Leu  Ile Ser Tyr 
    1595                 1600                 1605             


Lys His  Asp Gly Ser Glu Thr  Thr Glu Asp Ser Phe  Ser Leu Thr 
    1610                 1615                 1620             


Val Thr  Asp Gly Thr His Thr  Asp Phe Tyr Val Leu  Pro Asp Thr 
    1625                 1630                 1635             


Ala Leu  Ala Thr His Lys Pro  Gln Val Met Arg Val  Gln Ile Arg 
    1640                 1645                 1650             


Ser Leu  Asp Asn Arg Leu Pro  Gln Ile Thr Thr Asn  Arg Gly Ala 
    1655                 1660                 1665             


Pro Ala  Leu Lys Arg Leu His  Thr Gly His Met Gly  Phe Leu Ile 
    1670                 1675                 1680             


Thr Ser  Lys Ser Leu Lys Ala  Glu Asp Gln Asp Ser  Pro His Arg 
    1685                 1690                 1695             


Leu Leu  Lys Tyr Lys Val Thr  Arg Gly Pro Glu His  Gly Phe Ile 
    1700                 1705                 1710             


Ile Lys  Thr Gly Leu Gly Asn  Gln Ser Thr Arg Val  Phe Thr Gln 
    1715                 1720                 1725             


Ala Asp  Ile Asp Glu Met Lys  Ile Ser Tyr Val Leu  Asn Glu Gly 
    1730                 1735                 1740             


Ser Asn  Ala Ser Lys Asp Ile  Phe Tyr Phe Ser Val  Glu Asp Asn 
    1745                 1750                 1755             


Gly Gly  Asn Lys Leu Thr Asn  Gln Pro Phe His Leu  Asn Trp Ala 
    1760                 1765                 1770             


Trp Ile  Cys Leu Glu Lys Glu  Tyr Tyr Ile Val Asp  Glu Asp Ser 
    1775                 1780                 1785             


Thr Phe  Leu Glu Val Thr Leu  Thr Arg Arg Gly Tyr  Leu Gly Glu 
    1790                 1795                 1800             


Thr Ser  Phe Ile Ser Ile Gly  Thr Lys Asp Glu Thr  Ala Lys Lys 
    1805                 1810                 1815             


Asp Lys  Asp Phe Lys Trp Lys  Thr Asn Lys Gln Ile  Gln Phe Asn 
    1820                 1825                 1830             


Pro Gly  Gln Thr Thr Ala Thr  Trp Arg Val Arg Ile  Ile Pro Asp 
    1835                 1840                 1845             


Asn Glu  Tyr Glu Thr Ser Glu  Thr Phe Gln Ile Ile  Leu Ser Glu 
    1850                 1855                 1860             


Pro Leu  Met Ala Val Leu Glu  Phe Pro Glu Met Ala  Thr Val Glu 
    1865                 1870                 1875             


Ile Val  Asp Pro Gly Asp Glu  Ser Thr Val Tyr Ile  Pro Glu Ala 
    1880                 1885                 1890             


Glu Tyr  Lys Ile Glu Glu Asp  Ile Gly Glu Leu Leu  Ile Pro Val 
    1895                 1900                 1905             


Arg Arg  Ser Gly Asp Ala Ser  Gln Glu Leu Ile Val  Ile Cys Ser 
    1910                 1915                 1920             


Thr Arg  Gln Gly Ser Ala Thr  Gly Thr Ile Ser Ser  Thr Val Leu 
    1925                 1930                 1935             


Phe Ser  Asp Tyr Ile Ser Arg  Pro Glu Asp His Thr  Ser Ile Leu 
    1940                 1945                 1950             


His Phe  Asp Lys Asn Glu Thr  Gln Lys Thr Cys Gln  Val Leu Ile 
    1955                 1960                 1965             


Ile Asp  Asp Ser Leu Tyr Glu  Glu Glu Glu Ser Phe  Ser Val Ser 
    1970                 1975                 1980             


Leu Arg  Leu Pro Val Gly Gly  Gln Leu Gly Ala Arg  Phe Pro Thr 
    1985                 1990                 1995             


Thr Lys  Val Thr Ile Leu Ala  Asp Arg Tyr Asp Glu  Pro Val Leu 
    2000                 2005                 2010             


His Phe  Gly Asp Ala Glu Tyr  His Val Asn Glu Ser  Ala Arg Tyr 
    2015                 2020                 2025             


Val Glu  Val Cys Val Trp Arg  Arg Gly Thr Asp Leu  Ser Gln Pro 
    2030                 2035                 2040             


Ser Ser  Ile Ala Val Arg Ser  Arg Lys Ser Glu Gln  Glu Ser Ala 
    2045                 2050                 2055             


Glu Ala  Gly Thr Asp Tyr Val  Gly Ile Ser Arg Asn  Leu Asp Phe 
    2060                 2065                 2070             


Ala Pro  Gly Val Arg Met Gln  Thr Phe Gln Val Thr  Ile Leu Asp 
    2075                 2080                 2085             


Asp Leu  Gly Gln Pro Thr Leu  Glu Gly Pro Glu Lys  Phe Glu Leu 
    2090                 2095                 2100             


Leu Leu  Gln Met Pro Met Gly  Ala Val Leu Gly Glu  Pro Asn Lys 
    2105                 2110                 2115             


Thr Thr  Ile Phe Ile Glu Asp  Thr Ile Thr Asp Cys  Lys Gln Ser 
    2120                 2125                 2130             


Ala Cys  Ser Ser Phe Asp 
    2135                 


<210>  4178
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRG1__Homo_sapiens__NP_004468

<400>  4178

Met Ala Glu Tyr Ser Tyr Val Lys Ser Thr Lys Leu Val Leu Lys Gly 
1               5                   10                  15      


Thr Lys Thr Lys Ser Lys Lys Lys Lys Ser Lys Asp Lys Lys Arg Lys 
            20                  25                  30          


Arg Glu Glu Asp Glu Glu Thr Gln Leu Asp Ile Val Gly Ile Trp Trp 
        35                  40                  45              


Thr Val Thr Asn Phe Gly Glu Ile Ser Gly Thr Ile Ala Ile Glu Met 
    50                  55                  60                  


Asp Lys Gly Thr Tyr Ile His Ala Leu Asp Asn Gly Leu Phe Thr Leu 
65                  70                  75                  80  


Gly Ala Pro His Lys Glu Val Asp Glu Gly Pro Ser Pro Pro Glu Gln 
                85                  90                  95      


Phe Thr Ala Val Lys Leu Ser Asp Ser Arg Ile Ala Leu Lys Ser Gly 
            100                 105                 110         


Tyr Gly Lys Tyr Leu Gly Ile Asn Ser Asp Gly Leu Val Val Gly Arg 
        115                 120                 125             


Ser Asp Ala Ile Gly Pro Arg Glu Gln Trp Glu Pro Val Phe Gln Asn 
    130                 135                 140                 


Gly Lys Met Ala Leu Leu Ala Ser Asn Ser Cys Phe Ile Arg Cys Asn 
145                 150                 155                 160 


Glu Ala Gly Asp Ile Glu Ala Lys Ser Lys Thr Ala Gly Glu Glu Glu 
                165                 170                 175     


Met Ile Lys Ile Arg Ser Cys Ala Glu Arg Glu Thr Lys Lys Lys Asp 
            180                 185                 190         


Asp Ile Pro Glu Glu Asp Lys Gly Asn Val Lys Gln Cys Glu Ile Asn 
        195                 200                 205             


Tyr Val Lys Lys Phe Gln Ser Phe Gln Asp His Lys Leu Lys Ile Ser 
    210                 215                 220                 


Lys Glu Asp Ser Lys Ile Leu Lys Lys Ala Arg Lys Asp Gly Phe Leu 
225                 230                 235                 240 


His Glu Thr Leu Leu Asp Arg Arg Ala Lys Leu Lys Ala Asp Arg Tyr 
                245                 250                 255     


Cys Lys 
        


<210>  4179
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRG2__Homo_sapiens__NP_001005217

<400>  4179

Met Gly Lys Gly Asn Glu Asp Ser Asp Leu His Cys Ser Ser Ile Gln 
1               5                   10                  15      


Cys Ser Thr Asp Gln Pro Pro Phe Gln Gln Ile Ser Phe Thr Glu Lys 
            20                  25                  30          


Gly Ser Asp Glu Lys Lys Pro Phe Lys Glu Lys Gly Lys Thr Ala Phe 
        35                  40                  45              


Ser His Ser Ser Glu Lys His Ile Gln Arg Gln Gly Ser Glu Pro Asn 
    50                  55                  60                  


Pro Asn Lys Glu Asn Ser Glu Glu Thr Lys Leu Lys Ala Gly Asn Ser 
65                  70                  75                  80  


Thr Ala Gly Ser Glu Pro Glu Ser Ser Ser Tyr Arg Glu Asn Cys Arg 
                85                  90                  95      


Lys Arg Lys Met Ser Ser Lys Asp Ser Cys Gln Asp Thr Ala Gly Asn 
            100                 105                 110         


Cys Pro Glu Lys Glu Cys Ser Leu Ser Leu Asn Lys Lys Ser Arg Ser 
        115                 120                 125             


Ser Thr Ala Val His Asn Ser Glu Ile Gln Glu Thr Cys Asp Ala His 
    130                 135                 140                 


His Arg Gly His Ser Arg Ala Cys Thr Gly His Ser Lys Arg His Arg 
145                 150                 155                 160 


Ser Arg Ala Leu Gly Val Gln Thr Pro Ser Ile Arg Lys Ser Leu Val 
                165                 170                 175     


Thr Ser Val Arg Ala Met Ser Glu Ala Val Tyr Gln Asp Leu Ala Gln 
            180                 185                 190         


Val Trp Ala Gln Gln Ile His Ser Pro Leu Thr Cys Glu Gln Leu Thr 
        195                 200                 205             


Leu Leu Thr Arg Leu Arg Gly Pro Leu Cys Ala Gln Val Gln Thr Leu 
    210                 215                 220                 


Tyr Ser Met Ala Thr Gln Ala Ala Tyr Val Phe Pro Ala Glu Ser Trp 
225                 230                 235                 240 


Leu Val Pro Ala Thr Leu Pro Gly Pro Gly Glu Ser Ala Leu Asp Arg 
                245                 250                 255     


Glu Ala His Pro Phe Pro Gly Gln Glu Ile Thr Glu Thr Val Ser Gly 
            260                 265                 270         


Ser Asp Glu Ala Lys Leu 
        275             


<210>  4180
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRK__Homo_sapiens__XP_011533957

<400>  4180

Met Ser Asn Ile Cys Gln Arg Leu Trp Glu Tyr Leu Glu Pro Tyr Leu 
1               5                   10                  15      


Pro Cys Leu Ser Thr Glu Ala Asp Lys Ser Thr Val Ile Glu Asn Pro 
            20                  25                  30          


Gly Ala Leu Cys Ser Pro Gln Ser Gln Arg His Gly His Tyr Phe Val 
        35                  40                  45              


Ala Leu Phe Asp Tyr Gln Ala Arg Thr Ala Glu Asp Leu Ser Phe Arg 
    50                  55                  60                  


Ala Gly Asp Lys Leu Gln Val Leu Asp Thr Leu His Glu Gly Trp Trp 
65                  70                  75                  80  


Phe Ala Arg His Leu Glu Lys Arg Arg Asp Gly Ser Ser Gln Gln Leu 
                85                  90                  95      


Gln Gly Tyr Ile Pro Ser Asn Tyr Val Ala Glu Asp Arg Ser Leu Gln 
            100                 105                 110         


Ala Glu Pro Trp Phe Phe Gly Ala Ile Gly Arg Ser Asp Ala Glu Lys 
        115                 120                 125             


Gln Leu Leu Tyr Ser Glu Asn Lys Thr Gly Ser Phe Leu Ile Arg Glu 
    130                 135                 140                 


Ser Glu Ser Gln Lys Gly Glu Phe Ser Leu Ser Val Leu Asp Gly Ala 
145                 150                 155                 160 


Val Val Lys His Tyr Arg Ile Lys Arg Leu Asp Glu Gly Gly Phe Phe 
                165                 170                 175     


Leu Thr Arg Arg Arg Ile Phe Ser Thr Leu Asn Glu Phe Val Ser His 
            180                 185                 190         


Tyr Thr Lys Thr Ser Asp Gly Leu Cys Val Lys Leu Gly Lys Pro Cys 
        195                 200                 205             


Leu Lys Ile Gln Val Pro Ala Pro Phe Asp Leu Ser Tyr Lys Thr Val 
    210                 215                 220                 


Asp Gln Trp Glu Ile Asp Arg Asn Ser Ile Gln Leu Leu Lys Arg Leu 
225                 230                 235                 240 


Gly Ser Gly Gln Phe Gly Glu Val Trp Glu Gly Leu Trp Asn Asn Thr 
                245                 250                 255     


Thr Pro Val Ala Val Lys Thr Leu Lys Pro Gly Ser Met Asp Pro Asn 
            260                 265                 270         


Asp Phe Leu Arg Glu Ala Gln Ile Met Lys Asn Leu Arg His Pro Lys 
        275                 280                 285             


Leu Ile Gln Leu Tyr Ala Val Cys Thr Leu Glu Asp Pro Ile Tyr Ile 
    290                 295                 300                 


Ile Thr Glu Leu Met Arg His Gly Ser Leu Gln Glu Tyr Leu Gln Asn 
305                 310                 315                 320 


Asp Thr Gly Ser Lys Ile His Leu Thr Gln Gln Val Asp Met Ala Ala 
                325                 330                 335     


Gln Val Ala Ser Gly Met Ala Tyr Leu Glu Ser Arg Asn Tyr Ile His 
            340                 345                 350         


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu His Asn Ile Tyr 
        355                 360                 365             


Lys Val Ala Asp Phe Gly Leu Ala Arg Val Phe Lys Val Asp Asn Glu 
    370                 375                 380                 


Asp Ile Tyr Glu Ser Arg His Glu Ile Lys Leu Pro Val Lys Trp Thr 
385                 390                 395                 400 


Ala Pro Glu Ala Ile Arg Ser Asn Lys Phe Ser Ile Lys Ser Asp Val 
                405                 410                 415     


Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Ile Thr Tyr Gly Lys Met 
            420                 425                 430         


Pro Tyr Ser Gly Met Thr Gly Ala Gln Val Ile Gln Met Leu Ala Gln 
        435                 440                 445             


Asn Tyr Arg Leu Pro Gln Pro Ser Asn Cys Pro Gln Gln Phe Tyr Asn 
    450                 455                 460                 


Ile Met Leu Glu Cys Trp Asn Ala Glu Pro Lys Glu Arg Pro Thr Phe 
465                 470                 475                 480 


Glu Thr Leu Arg Trp Lys Leu Glu Asp Tyr Phe Glu Thr Asp Ser Ser 
                485                 490                 495     


Tyr Ser Asp Ala Asn Asn Phe Ile Arg 
            500                 505 


<210>  4181
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMD3__Homo_sapiens__NP_001231888

<400>  4181

Met Phe Ala Ser Cys His Cys Val Pro Arg Gly Arg Arg Thr Met Lys 
1               5                   10                  15      


Met Ile His Phe Arg Ser Ser Ser Val Lys Ser Leu Ser Gln Glu Met 
            20                  25                  30          


Arg Cys Thr Ile Arg Leu Leu Asp Asp Ser Glu Ile Ser Cys His Ile 
        35                  40                  45              


Gln Arg Glu Thr Lys Gly Gln Phe Leu Ile Asp His Ile Cys Asn Tyr 
    50                  55                  60                  


Tyr Ser Leu Leu Glu Lys Asp Tyr Phe Gly Ile Arg Tyr Val Asp Pro 
65                  70                  75                  80  


Glu Lys Gln Arg His Trp Leu Glu Pro Asn Lys Ser Ile Phe Lys Gln 
                85                  90                  95      


Met Lys Thr His Pro Pro Tyr Thr Met Cys Phe Arg Val Lys Phe Tyr 
            100                 105                 110         


Pro His Glu Pro Leu Lys Ile Lys Glu Glu Leu Thr Arg Tyr Leu Leu 
        115                 120                 125             


Tyr Leu Gln Ile Lys Arg Asp Ile Phe His Gly Arg Leu Leu Cys Ser 
    130                 135                 140                 


Phe Ser Asp Ala Ala Tyr Leu Gly Ala Cys Ile Val Gln Ala Glu Leu 
145                 150                 155                 160 


Gly Asp Tyr Asp Pro Asp Glu His Pro Glu Asn Tyr Ile Ser Glu Phe 
                165                 170                 175     


Glu Ile Phe Pro Lys Gln Ser Gln Lys Leu Glu Arg Lys Ile Val Glu 
            180                 185                 190         


Ile His Lys Asn Glu Leu Arg Gly Gln Ser Pro Pro Val Ala Glu Phe 
        195                 200                 205             


Asn Leu Leu Leu Lys Ala His Thr Leu Glu Thr Tyr Gly Val Asp Pro 
    210                 215                 220                 


His Pro Cys Lys Asp Ser Thr Gly Thr Thr Thr Phe Leu Gly Phe Thr 
225                 230                 235                 240 


Ala Ala Gly Phe Val Val Phe Gln Gly Asn Lys Arg Ile His Leu Ile 
                245                 250                 255     


Lys Trp Pro Asp Val Cys Lys Leu Lys Phe Glu Gly Lys Thr Phe Tyr 
            260                 265                 270         


Val Ile Gly Thr Gln Lys Glu Lys Lys Ala Met Leu Ala Phe His Thr 
        275                 280                 285             


Ser Thr Pro Ala Ala Cys Lys His Leu Trp Lys Cys Gly Val Glu Asn 
    290                 295                 300                 


Gln Ala Phe Tyr Lys Tyr Ala Lys Ser Ser Gln Ile Lys Thr Val Ser 
305                 310                 315                 320 


Ser Ser Lys Ile Phe Phe Lys Gly Ser Arg Phe Arg Tyr Ser Gly Lys 
                325                 330                 335     


Val Ala Lys Glu Val Val Glu Ala Ser Ser Lys Ile Gln Arg Glu Pro 
            340                 345                 350         


Pro Glu Val His Arg Ala Asn Ile Thr Gln Ser Arg Ser Ser His Ser 
        355                 360                 365             


Leu Asn Lys Gln Leu Ile Ile Asn Met Glu Pro Leu Gln Pro Leu Leu 
    370                 375                 380                 


Pro Ser Pro Ser Glu Gln Glu Glu Glu Leu Pro Leu Gly Glu Gly Val 
385                 390                 395                 400 


Pro Leu Pro Lys Glu Glu Asn Ile Ser Ala Pro Leu Ile Ser Ser Ser 
                405                 410                 415     


Pro Val Lys Ala Ala Arg Glu Tyr Glu Asp Pro Pro Ser Glu Glu Glu 
            420                 425                 430         


Asp Lys Ile Lys Glu Glu Pro Leu Thr Ile Ser Glu Leu Val Tyr Asn 
        435                 440                 445             


Pro Ser Ala Ser Leu Leu Pro Thr Pro Val Asp Asp Asp Glu Ile Asp 
    450                 455                 460                 


Met Leu Phe Asp Cys Pro Ser Arg Leu Glu Leu Glu Arg Glu Asp Thr 
465                 470                 475                 480 


Asp Ser Phe Glu Asp Leu Glu Ala Asp Glu Asn Ala Phe Leu Ile Ala 
                485                 490                 495     


Glu Glu Glu Glu Leu Lys Glu Ala Arg Arg Ala Leu Ser Trp Ser Tyr 
            500                 505                 510         


Asp Ile Leu Thr Gly His Ile Arg Val Asn Pro Leu Val Lys Ser Phe 
        515                 520                 525             


Ser Arg Leu Leu Val Val Gly Leu Gly Leu Leu Leu Phe Val Phe Pro 
    530                 535                 540                 


Leu Leu Leu Leu Leu Leu Glu Ser Val Ser Met Gln 
545                 550                 555     


<210>  4182
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMD4A__Homo_sapiens__NP_060497

<400>  4182

Met Ala Val Gln Leu Val Pro Asp Ser Ala Leu Gly Leu Leu Met Met 
1               5                   10                  15      


Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys Leu 
            20                  25                  30          


Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp Leu 
        35                  40                  45              


Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Ala 
    50                  55                  60                  


Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg Arg 
65                  70                  75                  80  


Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu Tyr 
                85                  90                  95      


Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp Asn 
            100                 105                 110         


Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr Lys 
        115                 120                 125             


Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser Tyr 
    130                 135                 140                 


Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val Arg 
145                 150                 155                 160 


Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys Glu 
                165                 170                 175     


His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr Lys 
            180                 185                 190         


Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met Ser 
        195                 200                 205             


Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val Lys 
    210                 215                 220                 


Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly Ile 
225                 230                 235                 240 


Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe Gln 
                245                 250                 255     


Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser Val 
            260                 265                 270         


Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe Gly 
        275                 280                 285             


His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu Ile 
    290                 295                 300                 


Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp 
305                 310                 315                 320 


Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser Glu 
                325                 330                 335     


Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys Leu 
            340                 345                 350         


Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly Ser 
        355                 360                 365             


Leu Leu Ser Ser Gly Ser Gln Glu Ser Asp Ser Ser Gln Ser Ala Lys 
    370                 375                 380                 


Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gln Glu Ala Leu Glu Glu 
385                 390                 395                 400 


Thr Leu Arg Gln Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu Arg Glu 
                405                 410                 415     


Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro Leu Asp Pro Gly 
            420                 425                 430         


Glu Glu Pro Pro Ile Val Arg Arg Arg Ile Gly Thr Ala Phe Lys Leu 
        435                 440                 445             


Asp Glu Gln Lys Ile Leu Pro Lys Gly Glu Glu Ala Glu Leu Glu Arg 
    450                 455                 460                 


Leu Glu Arg Glu Phe Ala Ile Gln Ser Gln Ile Thr Glu Ala Ala Arg 
465                 470                 475                 480 


Arg Leu Ala Ser Asp Pro Asn Val Ser Lys Lys Leu Lys Lys Gln Arg 
                485                 490                 495     


Lys Thr Ser Tyr Leu Asn Ala Leu Lys Lys Leu Gln Glu Ile Glu Asn 
            500                 505                 510         


Ala Ile Asn Glu Asn Arg Ile Lys Ser Gly Lys Lys Pro Thr Gln Arg 
        515                 520                 525             


Ala Ser Leu Ile Ile Asp Asp Gly Asn Ile Ala Ser Glu Asp Ser Ser 
    530                 535                 540                 


Leu Ser Asp Ala Leu Val Leu Glu Asp Glu Asp Ser Gln Val Thr Ser 
545                 550                 555                 560 


Thr Ile Ser Pro Leu His Ser Pro His Lys Gly Leu Pro Pro Arg Pro 
                565                 570                 575     


Pro Ser His Asn Arg Pro Pro Pro Pro Gln Ser Leu Glu Gly Leu Arg 
            580                 585                 590         


Gln Met His Tyr His Arg Asn Asp Tyr Asp Lys Ser Pro Ile Lys Pro 
        595                 600                 605             


Lys Met Trp Ser Glu Ser Ser Leu Asp Glu Pro Tyr Glu Lys Val Lys 
    610                 615                 620                 


Lys Arg Ser Ser His Ser His Ser Ser Ser His Lys Arg Phe Pro Ser 
625                 630                 635                 640 


Thr Gly Ser Cys Ala Glu Ala Gly Gly Gly Ser Asn Ser Leu Gln Asn 
                645                 650                 655     


Ser Pro Ile Arg Gly Leu Pro His Trp Asn Ser Gln Ser Ser Met Pro 
            660                 665                 670         


Ser Thr Pro Asp Leu Arg Val Arg Ser Pro His Tyr Val His Ser Thr 
        675                 680                 685             


Arg Ser Val Asp Ile Ser Pro Thr Arg Leu His Ser Leu Ala Leu His 
    690                 695                 700                 


Phe Arg His Arg Ser Ser Ser Leu Glu Ser Gln Gly Lys Leu Leu Gly 
705                 710                 715                 720 


Ser Glu Asn Asp Thr Gly Ser Pro Asp Phe Tyr Thr Pro Arg Thr Arg 
                725                 730                 735     


Ser Ser Asn Gly Ser Asp Pro Met Asp Asp Cys Ser Ser Cys Thr Ser 
            740                 745                 750         


His Ser Ser Ser Glu His Tyr Tyr Pro Ala Gln Met Asn Ala Asn Tyr 
        755                 760                 765             


Ser Thr Leu Ala Glu Asp Ser Pro Ser Lys Ala Arg Gln Arg Gln Arg 
    770                 775                 780                 


Gln Arg Gln Arg Ala Ala Gly Ala Leu Gly Ser Ala Ser Ser Gly Ser 
785                 790                 795                 800 


Met Pro Asn Leu Ala Ala Arg Gly Gly Ala Gly Gly Ala Gly Gly Ala 
                805                 810                 815     


Gly Gly Gly Val Tyr Leu His Ser Gln Ser Gln Pro Ser Ser Gln Tyr 
            820                 825                 830         


Arg Ile Lys Glu Tyr Pro Leu Tyr Ile Glu Gly Gly Ala Thr Pro Val 
        835                 840                 845             


Val Val Arg Ser Leu Glu Ser Asp Gln Glu Gly His Tyr Ser Val Lys 
    850                 855                 860                 


Ala Gln Phe Lys Thr Ser Asn Ser Tyr Thr Ala Gly Gly Leu Phe Lys 
865                 870                 875                 880 


Glu Ser Trp Arg Gly Gly Gly Gly Asp Glu Gly Asp Thr Gly Arg Leu 
                885                 890                 895     


Thr Pro Ser Arg Ser Gln Ile Leu Arg Thr Pro Ser Leu Gly Arg Glu 
            900                 905                 910         


Gly Ala His Asp Lys Gly Ala Gly Arg Ala Ala Val Ser Asp Glu Leu 
        915                 920                 925             


Arg Gln Trp Tyr Gln Arg Ser Thr Ala Ser His Lys Glu His Ser Arg 
    930                 935                 940                 


Leu Ser His Thr Ser Ser Thr Ser Ser Asp Ser Gly Ser Gln Tyr Ser 
945                 950                 955                 960 


Thr Ser Ser Gln Ser Thr Phe Val Ala His Ser Arg Val Thr Arg Met 
                965                 970                 975     


Pro Gln Met Cys Lys Ala Thr Ser Ala Ala Leu Pro Gln Ser Gln Arg 
            980                 985                 990         


Ser Ser Thr Pro Ser Ser Glu Ile  Gly Ala Thr Pro Pro  Ser Ser Pro 
        995                 1000                 1005             


His His  Ile Leu Thr Trp Gln  Thr Gly Glu Ala Thr  Glu Asn Ser 
    1010                 1015                 1020             


Pro Ile  Leu Asp Gly Ser Glu  Ser Pro Pro His Gln  Ser Thr Asp 
    1025                 1030                 1035             


Glu 
    


<210>  4183
<211>  1034
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMD4B__Homo_sapiens__NP_055938

<400>  4183

Met Ala Ser Val Phe Met Cys Gly Val Glu Asp Leu Leu Phe Ser Gly 
1               5                   10                  15      


Ser Arg Phe Val Trp Asn Leu Thr Val Ser Thr Leu Arg Arg Trp Tyr 
            20                  25                  30          


Thr Glu Arg Leu Arg Ala Cys His Gln Val Leu Arg Thr Trp Cys Gly 
        35                  40                  45              


Leu Gln Asp Val Tyr Gln Met Thr Glu Gly Arg His Cys Gln Val His 
    50                  55                  60                  


Leu Leu Asp Asp Arg Arg Leu Glu Leu Leu Val Gln Pro Lys Leu Leu 
65                  70                  75                  80  


Ala Arg Glu Leu Leu Asp Leu Val Ala Ser His Phe Asn Leu Lys Glu 
                85                  90                  95      


Lys Glu Tyr Phe Gly Ile Thr Phe Ile Asp Asp Thr Gly Gln Gln Asn 
            100                 105                 110         


Trp Leu Gln Leu Asp His Arg Val Leu Asp His Asp Leu Pro Lys Lys 
        115                 120                 125             


Pro Gly Pro Thr Ile Leu His Phe Ala Val Arg Phe Tyr Ile Glu Ser 
    130                 135                 140                 


Ile Ser Phe Leu Lys Asp Lys Thr Thr Val Glu Leu Phe Phe Leu Asn 
145                 150                 155                 160 


Ala Lys Ala Cys Val His Lys Gly Gln Ile Glu Val Glu Ser Glu Thr 
                165                 170                 175     


Ile Phe Lys Leu Ala Ala Phe Ile Leu Gln Glu Ala Lys Gly Asp Tyr 
            180                 185                 190         


Thr Ser Asp Glu Asn Ala Arg Lys Asp Leu Lys Thr Leu Pro Ala Phe 
        195                 200                 205             


Pro Thr Lys Thr Leu Gln Glu His Pro Ser Leu Ala Tyr Cys Glu Asp 
    210                 215                 220                 


Arg Val Ile Glu His Tyr Leu Lys Ile Lys Gly Leu Thr Arg Gly Gln 
225                 230                 235                 240 


Ala Val Val Gln Tyr Met Lys Ile Val Glu Ala Leu Pro Thr Tyr Gly 
                245                 250                 255     


Val His Tyr Tyr Ala Val Lys Asp Lys Gln Gly Leu Pro Trp Trp Leu 
            260                 265                 270         


Gly Ile Ser Tyr Lys Gly Ile Gly Gln Tyr Asp Ile Gln Asp Lys Val 
        275                 280                 285             


Lys Pro Arg Lys Leu Phe Gln Trp Lys Gln Leu Glu Asn Leu Tyr Phe 
    290                 295                 300                 


Arg Glu Lys Lys Phe Ala Val Glu Val His Asp Pro Arg Arg Ile Ser 
305                 310                 315                 320 


Val Ser Arg Arg Thr Phe Gly Gln Ser Gly Leu Phe Val Gln Thr Trp 
                325                 330                 335     


Tyr Ala Asn Ser Ser Leu Ile Lys Ser Ile Trp Val Met Ala Ile Ser 
            340                 345                 350         


Gln His Gln Phe Tyr Leu Asp Arg Lys Gln Ser Lys Ala Lys Ile Pro 
        355                 360                 365             


Ser Ala Arg Ser Leu Asp Glu Ile Ala Met Asp Leu Thr Glu Thr Gly 
    370                 375                 380                 


Thr Gln Arg Ala Ser Lys Leu Val Thr Leu Glu Ala Lys Ser Gln Phe 
385                 390                 395                 400 


Ile Met Ala Ser Asn Gly Ser Leu Ile Ser Ser Gly Ser Gln Asp Ser 
                405                 410                 415     


Glu Val Ser Glu Glu Gln Lys Arg Glu Lys Ile Leu Glu Leu Lys Lys 
            420                 425                 430         


Lys Glu Lys Leu Leu Gln Glu Lys Leu Leu Lys Lys Val Glu Glu Leu 
        435                 440                 445             


Lys Lys Ile Cys Leu Arg Glu Ala Glu Leu Thr Gly Lys Met Pro Lys 
    450                 455                 460                 


Glu Tyr Pro Leu Asn Ile Gly Glu Lys Pro Pro Gln Val Arg Arg Arg 
465                 470                 475                 480 


Val Gly Thr Ala Phe Lys Leu Asp Asp Asn Leu Leu Pro Ser Glu Glu 
                485                 490                 495     


Asp Pro Ala Leu Gln Glu Leu Glu Ser Asn Phe Leu Ile Gln Gln Lys 
            500                 505                 510         


Leu Val Glu Ala Ala Lys Lys Leu Ala Asn Glu Pro Asp Leu Cys Lys 
        515                 520                 525             


Thr Val Lys Lys Lys Arg Lys Gln Asp Tyr Thr Asp Ala Met Lys Lys 
    530                 535                 540                 


Leu Gln Glu Ile Glu Asn Ala Ile Asn Glu Tyr Arg Ile Arg Cys Gly 
545                 550                 555                 560 


Lys Lys Pro Ser Gln Lys Ala Thr Val Leu Pro Glu Asp Ile Ile Pro 
                565                 570                 575     


Ser Glu Ser Ser Ser Leu Ser Asp Thr Thr Thr Tyr Asp Asp Pro Ser 
            580                 585                 590         


Asp Ala Phe Thr Phe Pro Gly Gln Arg Ser Ser Ser Val Pro His Ser 
        595                 600                 605             


Pro Arg Ile Leu Pro Pro Lys Ser Leu Gly Ile Glu Arg Ile His Phe 
    610                 615                 620                 


Arg Lys Ser Ser Ile Asn Glu Gln Phe Val Asp Thr Arg Gln Ser Arg 
625                 630                 635                 640 


Glu Met Leu Ser Thr His Ser Ser Pro Tyr Lys Thr Leu Glu Arg Arg 
                645                 650                 655     


Pro Gln Gly Gly Arg Ser Met Pro Thr Thr Pro Val Leu Thr Arg Asn 
            660                 665                 670         


Ala Tyr Ser Ser Ser His Leu Glu Pro Glu Ser Ser Ser Gln His Cys 
        675                 680                 685             


Arg Gln Arg Ser Gly Ser Leu Glu Ser Gln Ser His Leu Leu Ser Glu 
    690                 695                 700                 


Met Asp Ser Asp Lys Pro Phe Phe Ser Leu Ser Lys Ser Gln Arg Ser 
705                 710                 715                 720 


Ser Ser Thr Glu Ile Leu Asp Asp Gly Ser Ser Tyr Thr Ser Gln Ser 
                725                 730                 735     


Ser Thr Glu Tyr Tyr Cys Val Thr Pro Val Thr Gly Pro Tyr Tyr Thr 
            740                 745                 750         


Thr Gln Thr Leu Asp Thr Arg Thr Arg Gly Arg Arg Arg Ser Lys Lys 
        755                 760                 765             


Gln Asn Val Ser Thr Ser Asn Ser Gly Ser Met Pro Asn Leu Ala Gln 
    770                 775                 780                 


Lys Asp Ser Leu Arg Asn Gly Val Tyr Ser Lys Ser Gln Glu Pro Pro 
785                 790                 795                 800 


Ser Ser Ser Tyr Tyr Ile Ala Gly Tyr Thr Pro Tyr Ala Glu Cys Asp 
                805                 810                 815     


Phe Tyr Tyr Ser Gly Gly Tyr Val Tyr Glu Asn Asp Thr Glu Gly Gln 
            820                 825                 830         


Tyr Ser Val Asn Pro Ser Tyr Arg Ser Ser Ala His Tyr Gly Tyr Glu 
        835                 840                 845             


Arg Gln Arg Asp Tyr Ser Arg Ser Phe His Glu Asp Glu Val Asp Arg 
    850                 855                 860                 


Val Pro His Asn Pro Tyr Ala Thr Leu Arg Leu Pro Arg Lys Ala Ala 
865                 870                 875                 880 


Ala Lys Ser Glu His Ile Thr Lys Asn Ile His Lys Ala Leu Val Ala 
                885                 890                 895     


Glu His Leu Arg Gly Trp Tyr Gln Arg Ala Ser Gly Gln Lys Asp Gln 
            900                 905                 910         


Gly His Ser Pro Gln Thr Ser Phe Asp Ser Asp Arg Gly Ser Gln Arg 
        915                 920                 925             


Cys Leu Gly Phe Ala Gly Leu Gln Val Pro Cys Ser Pro Ser Ser Arg 
    930                 935                 940                 


Ala Ser Ser Tyr Ser Ser Val Ser Ser Thr Asn Ala Ser Gly Asn Trp 
945                 950                 955                 960 


Arg Thr Gln Leu Thr Ile Gly Leu Ser Asp Tyr Glu Thr Pro Ala His 
                965                 970                 975     


Ser Ser Tyr Thr Ser Cys Tyr Gly Asn Val Tyr Asn Pro Leu Pro Ser 
            980                 985                 990         


Pro Ser Arg Gln Tyr Thr Glu Ile  Ser Gln Leu Asp Gly  Thr Asp Gly 
        995                 1000                 1005             


Asn Gln  Leu Glu Asp Asn Leu  Glu Ser Ser Glu Gln  Arg Leu Phe 
    1010                 1015                 1020             


Trp His  Glu Asp Ser Lys Pro  Gly Thr Leu Val 
    1025                 1030                 


<210>  4184
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMD5__Homo_sapiens__NP_001273419

<400>  4184

Met Cys Phe Arg Val Lys Phe Tyr Pro Ala Asp Pro Ala Ala Leu Lys 
1               5                   10                  15      


Glu Glu Ile Thr Arg Tyr Leu Val Phe Leu Gln Ile Lys Arg Asp Leu 
            20                  25                  30          


Tyr His Gly Arg Leu Leu Cys Lys Thr Ser Asp Ala Ala Leu Leu Ala 
        35                  40                  45              


Ala Tyr Ile Leu Gln Ala Glu Ile Gly Asp Tyr Asp Ser Gly Lys His 
    50                  55                  60                  


Pro Glu Gly Tyr Ser Ser Lys Phe Gln Phe Phe Pro Lys His Ser Glu 
65                  70                  75                  80  


Lys Leu Glu Arg Lys Ile Ala Glu Ile His Lys Thr Glu Leu Ser Gly 
                85                  90                  95      


Gln Thr Pro Ala Thr Ser Glu Leu Asn Phe Leu Arg Lys Ala Gln Thr 
            100                 105                 110         


Leu Glu Thr Tyr Gly Val Asp Pro His Pro Cys Lys Asp Val Ser Gly 
        115                 120                 125             


Asn Ala Ala Phe Leu Ala Phe Thr Pro Phe Gly Phe Val Val Leu Gln 
    130                 135                 140                 


Gly Asn Lys Arg Val His Phe Ile Lys Trp Asn Glu Val Thr Lys Leu 
145                 150                 155                 160 


Lys Phe Glu Gly Lys Thr Phe Tyr Leu Tyr Glu Lys Lys Ile Ile Leu 
                165                 170                 175     


Thr Tyr Phe Ala Pro Thr Pro Glu Ala Cys Lys His Leu Trp Lys Cys 
            180                 185                 190         


Gly Ile Glu Asn Gln Ala Phe Tyr Lys Leu Glu Lys Ser Ser Gln Val 
        195                 200                 205             


Arg Thr Val Ser Ser Ser Asn Leu Phe Phe Lys Gly Ser Arg Phe Arg 
    210                 215                 220                 


Tyr Ser Gly Arg Val Ala Lys Glu Val Met Glu Ser Ser Ala Lys Ile 
225                 230                 235                 240 


Lys Arg Glu Pro Pro Glu Ile His Arg Ala Gly Met Val Pro Ser Arg 
                245                 250                 255     


Ser Cys Pro Ser Ile Thr His Gly Pro Arg Leu Ser Ser Val Pro Arg 
            260                 265                 270         


Thr Arg Arg Arg Ala Val His Ile Ser Ile Met Glu Gly Leu Glu Ser 
        275                 280                 285             


Leu Arg Asp Ser Ala His Ser Thr Pro Val Arg Ser Thr Ser His Gly 
    290                 295                 300                 


Asp Thr Phe Leu Pro His Val Arg Ser Ser Arg Thr Asp Ser Asn Glu 
305                 310                 315                 320 


Arg Val Ala Val Ile Ala Asp Glu Ala Tyr Ser Pro Ala Asp Ser Val 
                325                 330                 335     


Leu Pro Thr Pro Val Ala Glu His Ser Leu Glu Leu Met Leu Leu Ser 
            340                 345                 350         


Arg Gln Ile Asn Gly Ala Thr Cys Ser Ile Glu Glu Glu Lys Glu Ser 
        355                 360                 365             


Glu Ala Ser Thr Pro Thr Ala Thr Glu Val Glu Ala Leu Gly Gly Glu 
    370                 375                 380                 


Leu Arg Ala Leu Cys Gln Gly His Ser Gly Pro Glu Glu Glu Gln Ala 
385                 390                 395                 400 


Met Val Cys Leu Gln Asn Pro Leu Ser Gly Glu Pro Ala His 
                405                 410                 


<210>  4185
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMD6__Homo_sapiens__NP_001253976

<400>  4185

Met Asp Gln Leu Glu Lys Arg Ser Arg Ala Ser Gly Ser Ser Ala Gly 
1               5                   10                  15      


Ser Met Lys His Lys Arg Leu Ser Arg His Ser Thr Ala Ser His Ser 
            20                  25                  30          


Ser Ser His Thr Ser Gly Ile Glu Ala Asp Thr Lys Pro Arg Asp Thr 
        35                  40                  45              


Gly Pro Glu Asp Ser Tyr Ser Ser Ser Ala Ile His Arg Lys Leu Lys 
    50                  55                  60                  


Thr Cys Ser Ser Met Thr Ser His Gly Ser Ser His Thr Ser Gly Val 
65                  70                  75                  80  


Glu Ser Gly Gly Lys Asp Arg Leu Glu Glu Asp Leu Gln Asp Asp Glu 
                85                  90                  95      


Ile Glu Met Leu Val Asp Asp Pro Arg Asp Leu Glu Gln Met Asn Glu 
            100                 105                 110         


Glu Ser Leu Glu Val Ser Pro Asp Met Cys Ile Tyr Ile Thr Glu Asp 
        115                 120                 125             


Met Leu Met Ser Arg Lys Leu Asn Gly His Ser Gly Leu Ile Val Lys 
    130                 135                 140                 


Glu Ile Gly Ser Ser Thr Ser Ser Ser Ser Glu Thr Val Val Lys Leu 
145                 150                 155                 160 


Arg Gly Gln Ser Thr Asp Ser Leu Pro Gln Thr Ile Cys Arg Lys Pro 
                165                 170                 175     


Lys Thr Ser Thr Asp Arg His Ser Leu Ser Leu Asp Asp Ile Arg Leu 
            180                 185                 190         


Tyr Gln Lys Asp Phe Leu Arg Ile Ala Gly Leu Cys Gln Asp Thr Ala 
        195                 200                 205             


Gln Ser Tyr Thr Phe Gly Cys Gly His Glu Leu Asp Glu Glu Gly Leu 
    210                 215                 220                 


Tyr Cys Asn Ser Cys Leu Ala Gln Gln Cys Ile Asn Ile Gln Asp Ala 
225                 230                 235                 240 


Phe Pro Val Lys Arg Thr Ser Lys Tyr Phe Ser Leu Asp Leu Thr His 
                245                 250                 255     


Asp Glu Val Pro Glu Phe Val Val 
            260                 


<210>  4186
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMD7__Homo_sapiens__NP_919253

<400>  4186

Met Leu His Leu Lys Val Gln Phe Leu Asp Asp Ser Gln Lys Ile Phe 
1               5                   10                  15      


Val Val Asp Gln Lys Ser Ser Gly Lys Ala Leu Phe Asn Leu Ser Cys 
            20                  25                  30          


Ser His Leu Asn Leu Ala Glu Lys Glu Tyr Phe Gly Leu Glu Phe Cys 
        35                  40                  45              


Ser His Ser Gly Asn Asn Val Trp Leu Glu Leu Leu Lys Pro Ile Thr 
    50                  55                  60                  


Lys Gln Val Lys Asn Pro Lys Glu Ile Val Phe Lys Phe Met Val Lys 
65                  70                  75                  80  


Phe Phe Pro Val Asp Pro Gly His Leu Arg Glu Glu Leu Thr Arg Tyr 
                85                  90                  95      


Leu Phe Thr Leu Gln Ile Lys Lys Asp Leu Ala Leu Gly Arg Leu Pro 
            100                 105                 110         


Cys Ser Asp Asn Cys Thr Ala Leu Met Val Ser His Ile Leu Gln Ser 
        115                 120                 125             


Glu Leu Gly Asp Phe His Glu Glu Thr Asp Arg Lys His Leu Ala Gln 
    130                 135                 140                 


Thr Arg Tyr Leu Pro Asn Gln Asp Cys Leu Glu Gly Lys Ile Met His 
145                 150                 155                 160 


Phe His Gln Lys His Ile Gly Arg Ser Pro Ala Glu Ser Asp Ile Leu 
                165                 170                 175     


Leu Leu Asp Ile Ala Arg Lys Leu Asp Met Tyr Gly Ile Arg Pro His 
            180                 185                 190         


Pro Ala Ser Asp Gly Glu Gly Met Gln Ile His Leu Ala Val Ala His 
        195                 200                 205             


Met Gly Val Leu Val Leu Arg Gly Asn Thr Lys Ile Asn Thr Phe Asn 
    210                 215                 220                 


Trp Ala Lys Ile Arg Lys Leu Ser Phe Lys Arg Lys His Phe Leu Ile 
225                 230                 235                 240 


Lys Leu His Ala Asn Ile Leu Val Leu Cys Lys Asp Thr Leu Glu Phe 
                245                 250                 255     


Thr Met Ala Ser Arg Asp Ala Cys Lys Ala Phe Trp Lys Thr Cys Val 
            260                 265                 270         


Glu Tyr His Ala Phe Phe Arg Leu Ser Glu Glu Pro Lys Ser Lys Pro 
        275                 280                 285             


Lys Thr Leu Leu Cys Ser Lys Gly Ser Ser Phe Arg Tyr Ser Gly Arg 
    290                 295                 300                 


Thr Gln Arg Gln Leu Leu Glu Tyr Gly Arg Lys Gly Arg Leu Lys Ser 
305                 310                 315                 320 


Leu Pro Phe Glu Arg Lys His Tyr Pro Ser Gln Tyr His Glu Arg Gln 
                325                 330                 335     


Cys Arg Ser Ser Pro Asp Leu Leu Ser Asp Val Ser Lys Gln Val Glu 
            340                 345                 350         


Asp Leu Arg Leu Ala Tyr Gly Gly Gly Tyr Tyr Gln Asn Val Asn Gly 
        355                 360                 365             


Val His Ala Ser Glu Pro Val Leu Glu Ser Arg Arg Arg Asn Ser Ala 
    370                 375                 380                 


Leu Glu Val Thr Phe Ala Thr Glu Leu Glu His Ser Lys Pro Glu Ala 
385                 390                 395                 400 


Asp Pro Thr Leu Leu His Gln Ser Gln Ser Ser Ser Ser Phe Pro Phe 
                405                 410                 415     


Ile Tyr Met Asp Pro Val Phe Asn Thr Glu Pro Asn Pro Asn Pro Asp 
            420                 425                 430         


Pro Arg Asp Ile Phe Ser Glu Arg Ser Ser Leu Ser Ser Phe Gln Thr 
        435                 440                 445             


Ser Cys Lys Phe Ser Gly Asn His Met Ser Ile Tyr Ser Gly Leu Thr 
    450                 455                 460                 


Ser Lys Val Arg Pro Ala Lys Gln Leu Thr Tyr Thr Asp Val Pro Tyr 
465                 470                 475                 480 


Ile Pro Cys Thr Gly Gln Gln Val Gly Ile Met Pro Pro Gln Val Phe 
                485                 490                 495     


Phe Tyr Val Asp Lys Pro Pro Gln Val Pro Arg Trp Ser Pro Ile Arg 
            500                 505                 510         


Ala Glu Glu Arg Thr Ser Pro His Ser Tyr Val Glu Pro Thr Ala Met 
        515                 520                 525             


Lys Pro Ala Glu Arg Ser Pro Arg Asn Ile Arg Met Lys Ser Phe Gln 
    530                 535                 540                 


Gln Asp Leu Gln Val Leu Gln Glu Ala Ile Ala Arg Thr Ser Gly Arg 
545                 550                 555                 560 


Ser Asn Ile Asn Val Gly Leu Glu Glu Glu Asp Pro Asn Leu Glu Asp 
                565                 570                 575     


Ala Phe Val Cys Asn Ile Gln Glu Gln Thr Pro Lys Arg Ser Gln Ser 
            580                 585                 590         


Gln Ser Asp Met Lys Thr Ile Arg Phe Pro Phe Gly Ser Glu Phe Arg 
        595                 600                 605             


Pro Leu Gly Pro Cys Pro Ala Leu Ser His Lys Ala Asp Leu Phe Thr 
    610                 615                 620                 


Asp Met Phe Ala Glu Gln Glu Leu Pro Ala Val Leu Met Asp Gln Ser 
625                 630                 635                 640 


Thr Ala Glu Arg Tyr Val Ala Ser Glu Ser Ser Asp Ser Glu Ser Glu 
                645                 650                 655     


Ile Leu Lys Pro Asp Tyr Tyr Ala Leu Tyr Gly Lys Glu Ile Arg Ser 
            660                 665                 670         


Pro Met Ala Arg Ile Arg Leu Ser Ser Gly Ser Leu Gln Leu Asp Glu 
        675                 680                 685             


Glu Asp Glu Asp Ala Tyr Phe Asn Thr Pro Thr Ala Glu Asp Arg Thr 
    690                 695                 700                 


Ser Leu Lys Pro Cys Asn Tyr Phe Leu Ala 
705                 710                 


<210>  4187
<211>  1578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMPD1__Homo_sapiens__NP_055722

<400>  4187

Met Glu Glu Leu Glu Thr Ser Leu Phe Gln Thr Arg Lys Ala His Arg 
1               5                   10                  15      


Ile Glu Gln Met Val Ala Arg Trp Leu Arg Arg Ser Arg Asp Ser Ser 
            20                  25                  30          


Ala Arg Ala Lys Val Ala Ala Ala Asp Gly Pro Ala Arg Asn Pro Thr 
        35                  40                  45              


Gln Thr Leu Ile Pro Val Arg His Thr Val Lys Ile Asp Lys Asp Thr 
    50                  55                  60                  


Leu Leu Gln Asp Tyr Gly Phe His Ile Ser Glu Ser Leu Pro Leu Thr 
65                  70                  75                  80  


Val Val Ala Val Thr Ala Gly Gly Ser Ala His Gly Lys Leu Phe Pro 
                85                  90                  95      


Gly Asp Gln Ile Leu Gln Met Asn Asn Glu Pro Ala Glu Asp Leu Ser 
            100                 105                 110         


Trp Glu Arg Ala Val Asp Ile Leu Arg Glu Ala Glu Asp Ser Leu Ser 
        115                 120                 125             


Ile Thr Val Val Arg Cys Thr Ser Gly Val Pro Lys Ser Ser Phe Leu 
    130                 135                 140                 


Thr Glu Glu Lys Arg Ala Arg Leu Lys Thr Asn Pro Val Lys Val His 
145                 150                 155                 160 


Phe Ala Glu Glu Val Leu Ile Ser Gly His Ser Gln Gly Asn Ser Leu 
                165                 170                 175     


Leu Cys Met Pro Asn Val Leu Lys Leu Tyr Leu Glu Asn Gly Gln Thr 
            180                 185                 190         


Lys Ala Phe Lys Phe Glu Ala Asn Thr Thr Val Lys Asp Ile Ile Leu 
        195                 200                 205             


Thr Val Lys Glu Lys Leu Ser Ile Arg Ser Ile Glu Tyr Phe Ala Leu 
    210                 215                 220                 


Ala Leu Glu Glu Gln Tyr Ser Ile Ser Arg Leu His Leu Leu His Glu 
225                 230                 235                 240 


Glu Glu Leu Ile Gln Gln Val Val Glu Arg Glu Glu Ser His Asp Tyr 
                245                 250                 255     


Arg Cys Leu Phe Arg Val Cys Phe Val Pro Lys Asp Pro Leu Asp Leu 
            260                 265                 270         


Leu Lys Glu Asp Pro Val Ala Phe Glu Tyr Leu Tyr Leu Gln Ser Cys 
        275                 280                 285             


Ser Asp Val Leu Gln Glu Arg Phe Ala Val Glu Met Lys Cys Ser Ser 
    290                 295                 300                 


Ala Leu Arg Leu Ala Ala Leu His Ile Gln Glu Arg Ile Tyr Ala Cys 
305                 310                 315                 320 


Ala Gln Pro Gln Lys Ile Ser Leu Lys Tyr Ile Glu Lys Asp Trp Gly 
                325                 330                 335     


Ile Glu Asn Phe Ile Ser Pro Thr Leu Leu Arg Asn Met Lys Gly Lys 
            340                 345                 350         


Asp Ile Lys Lys Ala Ile Ser Phe His Met Lys Arg Asn Gln Asn Leu 
        355                 360                 365             


Leu Glu Pro Arg Gln Lys Gln Leu Ile Ser Ala Ala Gln Leu Arg Leu 
    370                 375                 380                 


Asn Tyr Leu Gln Ile Leu Gly Glu Leu Lys Thr Tyr Gly Gly Arg Ile 
385                 390                 395                 400 


Phe Asn Ala Thr Leu Met Leu Gln Asp Arg Glu Ser Tyr Ile Ala Leu 
                405                 410                 415     


Leu Val Gly Ala Lys Tyr Gly Ile Ser Gln Val Ile Asn Ser Lys Leu 
            420                 425                 430         


Asn Ile Met Ser Thr Leu Ala Glu Phe Ala Asn Ile Ser Arg Val Glu 
        435                 440                 445             


Leu Thr Glu Glu Ser Glu Lys Val Ser Val Val Lys Val Tyr Leu Gln 
    450                 455                 460                 


Asp Val Lys Val Leu Thr Leu Leu Leu Glu Ser Asn Ser Ala Lys Asp 
465                 470                 475                 480 


Leu Ala Cys Leu Ile Ala Gly Tyr Tyr Arg Leu Leu Val Asp Pro Val 
                485                 490                 495     


Thr Ser Ile Phe Leu Trp Pro Gly Asn Lys Gln Gln Ala His Arg Val 
            500                 505                 510         


Ser Ala Glu Glu Gly Tyr Glu Ser Arg Ala Cys Ser Asp Ser Glu Glu 
        515                 520                 525             


Ser Ser Glu Val Asp Cys Val Leu Glu Pro Leu Ser Asp Arg Arg Leu 
    530                 535                 540                 


Val Lys Leu Ala Pro Cys Arg Ser Leu Ile Lys Glu Glu Gln Pro Pro 
545                 550                 555                 560 


Gly Asn Ser Pro Thr Pro Glu Val Ala Arg Arg Gly Pro Ser Thr Cys 
                565                 570                 575     


Gly Ala Ser Ser Thr Thr Asp Ser Ala Glu Ser Glu Ala Ser Asp Ser 
            580                 585                 590         


Ala Asn Thr Glu Ser Arg Gly Tyr Arg Thr Ser Gly Ser Ser Glu Ser 
        595                 600                 605             


Met Asp Ala Leu Glu Glu Asp Asp Leu Asp Thr Cys Ser Ser Ser Arg 
    610                 615                 620                 


Ser Thr Phe Phe His Phe Gly Ser Pro Gly Leu Ala Glu Ser Ile Asp 
625                 630                 635                 640 


Ser Asp Ser Gln Glu Glu Arg Ser Gly Ile Glu Thr Ser Gly Phe Leu 
                645                 650                 655     


Cys Leu Leu Asp Leu Ala Gln Arg Ala Asn Pro Gln Cys Gln Lys Thr 
            660                 665                 670         


Glu Phe Ser Glu Ser Ala Ala Leu Glu Thr Phe Gly Trp Ala Pro Glu 
        675                 680                 685             


Leu Ser Thr Val Arg Leu Asp Pro Arg Leu Tyr Glu Gly Ser His Ala 
    690                 695                 700                 


Asp Tyr Tyr Ser Leu Cys Ser Ser Val Ser Pro Ala Ser Tyr Leu Ser 
705                 710                 715                 720 


Asp Ser Ser Glu Ser Thr Ala Ser Arg Gln Gly Gly Ala Pro Pro Ala 
                725                 730                 735     


Trp Gly Gln Gln Gly Trp Thr Glu Ala Gln Pro Ser Ser Met Leu Glu 
            740                 745                 750         


Pro Leu Ala Leu His Pro Pro Leu Ala Phe Glu Asp Gly Ser Ser Asp 
        755                 760                 765             


Glu Glu Tyr Tyr Asp Ala Ala Asp Lys Leu Thr Pro Pro Gly Pro Pro 
    770                 775                 780                 


Ser Gly Pro Arg Asp Val Ser Thr Ala Glu Pro Ser Ala Thr Ser Leu 
785                 790                 795                 800 


Gln Asn Lys Ala Ser Thr Ser Ser Pro Glu Asn Ser Leu Pro Cys Gly 
                805                 810                 815     


Pro Asp Gly Arg Gln Pro Ser Arg Arg Gly Gly Val Lys Lys Tyr Ala 
            820                 825                 830         


Lys Thr Leu Arg Lys Arg Arg Ser Phe Leu Gln Thr Asp Tyr Thr Ser 
        835                 840                 845             


Gln Val Ser Phe Pro Leu Val Pro Ser Ala Ser Leu Glu Ser Val Asp 
    850                 855                 860                 


Asp Val Cys Tyr Tyr Asp Arg Glu Pro Tyr Leu Ala Leu Gly Ala Pro 
865                 870                 875                 880 


Ser Pro Thr Val Ser Ser Leu Gln Asp Met Gln Gly Glu Pro Gly Leu 
                885                 890                 895     


Leu Glu Thr Lys Ala Leu Gly Leu Leu Ala Pro Leu Arg Glu Thr Lys 
            900                 905                 910         


Ser Thr Asn Pro Ala Ser Arg Val Met Glu Met Glu Pro Glu Thr Met 
        915                 920                 925             


Glu Thr Lys Ser Val Ile Asp Ser Arg Val Ser Ser Ile Ser Ala Ile 
    930                 935                 940                 


Arg Phe Arg Ile Asp Pro Asn Asn Lys Glu Asn Ser Gly Val Val Pro 
945                 950                 955                 960 


Ala Ala Ser Ser Ser Ala Ser Thr Pro His Cys Ser Asn Pro Gly Ser 
                965                 970                 975     


Ser Gly Pro Asp Thr Ala Gln Ala Arg Pro Ser Gln Ile Leu Pro Leu 
            980                 985                 990         


Ser Gln Asp Leu Asp Gly Ile Ala  Pro Lys Glu Pro Thr  Ile Glu His 
        995                 1000                 1005             


Gly Asp  Ser Ser Phe Ser Leu  Ser Ser Gly Asp Pro  Asn Pro Asp 
    1010                 1015                 1020             


Arg Ala  Cys Leu Ala Ser Asn  Pro Gly Leu Asn Asn  Val Ser Gln 
    1025                 1030                 1035             


Gly Asp  Thr Leu Glu Leu Gln  Leu Glu Pro His Val  Gln Leu Glu 
    1040                 1045                 1050             


Met Gly  Leu Glu Ser Phe Cys  Thr Asn His Ile Gln  Glu Thr Ala 
    1055                 1060                 1065             


Pro Lys  Tyr Thr Glu Pro Leu  Leu Ser Pro Arg Asp  Glu Pro Arg 
    1070                 1075                 1080             


Ser Asp  Glu Cys Gly Ile Asn  Pro Gly Glu Lys Ile  Ala Ser Ile 
    1085                 1090                 1095             


Pro Thr  Lys Glu Glu Pro Gln  Gly Gln Leu Ser Leu  Glu Arg Asp 
    1100                 1105                 1110             


Arg Glu  Val Thr Asn Lys Asn  Gly Thr Asn Val Phe  Gln Glu Glu 
    1115                 1120                 1125             


Ser Arg  Lys Asp Ser Gly Asp  Ser Pro Gly Asp Val  Ser Asn Asn 
    1130                 1135                 1140             


Val Ser  Gln Thr Leu Asp Ile  Ser Ser Pro Ala Gly  Lys Ile Val 
    1145                 1150                 1155             


Thr Ser  Leu Ser Leu Asp Ala  Pro Val Thr Gly Thr  Glu Gln Ile 
    1160                 1165                 1170             


Pro Pro  His Pro Pro Arg Asp  Pro Gln Gly Gln Ser  Arg Glu Pro 
    1175                 1180                 1185             


Pro Gly  Gln Gly Cys Gln Ala  Gln Glu Gln Lys Leu  Phe Val Glu 
    1190                 1195                 1200             


Leu Asp  Leu Asp Pro Asp Phe  Phe Leu Gly Lys Gln  Thr Val Ser 
    1205                 1210                 1215             


Pro Ala  Val Pro Pro Glu Gly  Ile Lys Ala Glu Ala  Pro Asn His 
    1220                 1225                 1230             


Val Thr  Gly Gln Asp Ile Ala  Pro Arg Asp Ser Pro  Glu Trp Val 
    1235                 1240                 1245             


Cys Phe  Asn Pro Glu Pro Ser  Leu Pro Glu Pro Leu  Pro Cys Pro 
    1250                 1255                 1260             


Gln Glu  Asp Pro His Leu Glu  Thr Ser Asn His Cys  Leu Leu Ser 
    1265                 1270                 1275             


Glu Gly  Lys Ser Asp Ser Ser  Ser Ile Cys Leu Ser  Ala Glu Lys 
    1280                 1285                 1290             


Ser Phe  Leu Cys Phe Ala Pro  Glu Ser His Pro Glu  Val Ser Ala 
    1295                 1300                 1305             


Ser Leu  Arg Val Ala Thr Ser  Leu Gly Phe Ala Gly  Met Asn Glu 
    1310                 1315                 1320             


Met Val  Ala Pro Arg Ile Gly  Met Asp Gln Cys Ser  Cys Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Ala Thr Cys Phe Arg  Gly Pro Gln Pro Glu  Thr Glu Glu 
    1340                 1345                 1350             


Glu Asp  Arg Asp Leu Glu Ala  His Pro Met Ala Pro  Leu Thr Ser 
    1355                 1360                 1365             


Pro Pro  Ser Ala Gly Ser Pro  Val Val Leu Pro Trp  Arg Pro Ala 
    1370                 1375                 1380             


Arg Ala  His Ser Cys Thr Thr  Ala Pro Leu Ser Arg  Lys Ser His 
    1385                 1390                 1395             


Ile Trp  Pro Glu Tyr Cys Ser  Arg Ala Leu Arg Gln  Leu Lys Ala 
    1400                 1405                 1410             


Thr Pro  Ala Ser Thr Pro Glu  Gly Phe Ile Gln Leu  Met Glu Ser 
    1415                 1420                 1425             


Leu Leu  Glu Leu Gln Asp Ile  Leu Glu Thr Ser Trp  Gly Val Gly 
    1430                 1435                 1440             


Asn Lys  His Pro Pro Glu Lys  Cys Thr Trp His Phe  Thr Glu Ser 
    1445                 1450                 1455             


Arg Ser  Arg Leu Cys Met Gly  Ser Gln Lys Leu Leu  Ser Ser Cys 
    1460                 1465                 1470             


Arg His  Val Ile Arg Met Asp  Gln Ser Pro Glu Glu  Met Gln Gly 
    1475                 1480                 1485             


Ala Val  Arg Asp Thr Phe Gln  His Leu Val Gln Leu  Ala Gly Leu 
    1490                 1495                 1500             


Cys Phe  Gln Phe Thr Asp Cys  Ser Arg Cys Ser Ala  Arg His Arg 
    1505                 1510                 1515             


Glu Ala  Ala Gly Asn Leu Arg  Asp Val Val Tyr Thr  Tyr His Gln 
    1520                 1525                 1530             


Phe Ile  Glu Ala Ala Lys Ser  Thr Cys Glu Arg Gly  Tyr His Asp 
    1535                 1540                 1545             


Leu Ser  Val Lys Leu Leu Ala  Arg Gln Cys Thr Ala  Leu Thr Ala 
    1550                 1555                 1560             


Ala Val  Phe Cys Leu Thr Gln  Lys Phe Arg Ala Ser  Thr Ala Leu 
    1565                 1570                 1575             


<210>  4188
<211>  1309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMPD2__Homo_sapiens__NP_001018081

<400>  4188

Met Gln Pro Leu Thr Lys Asp Ala Gly Met Ser Leu Ser Ser Val Thr 
1               5                   10                  15      


Leu Ala Ser Ala Leu Gln Val Arg Gly Glu Ala Leu Ser Glu Glu Glu 
            20                  25                  30          


Ile Trp Ser Leu Leu Phe Leu Ala Ala Glu Gln Leu Leu Glu Asp Leu 
        35                  40                  45              


Arg Asn Asp Ser Ser Asp Tyr Val Val Cys Pro Trp Ser Ala Leu Leu 
    50                  55                  60                  


Ser Ala Ala Gly Ser Leu Ser Phe Gln Gly Arg Val Ser His Ile Glu 
65                  70                  75                  80  


Ala Ala Pro Phe Lys Ala Pro Glu Leu Leu Gln Gly Gln Ser Glu Asp 
                85                  90                  95      


Glu Gln Pro Asp Ala Ser Gln Met His Val Tyr Ser Leu Gly Met Thr 
            100                 105                 110         


Leu Tyr Trp Ser Ala Gly Phe His Val Pro Pro His Gln Pro Leu Gln 
        115                 120                 125             


Leu Cys Glu Pro Leu His Ser Ile Leu Leu Thr Met Cys Glu Asp Gln 
    130                 135                 140                 


Pro His Arg Arg Cys Thr Leu Gln Ser Val Leu Glu Ala Cys Arg Val 
145                 150                 155                 160 


His Glu Lys Glu Val Ser Val Tyr Pro Ala Pro Ala Gly Leu His Ile 
                165                 170                 175     


Arg Arg Leu Val Gly Leu Val Leu Gly Thr Ile Ser Glu Val Glu Lys 
            180                 185                 190         


Arg Val Val Glu Glu Ser Ser Ser Val Gln Gln Asn Arg Ser Tyr Leu 
        195                 200                 205             


Leu Arg Lys Arg Leu Arg Gly Thr Ser Ser Glu Ser Pro Ala Ala Gln 
    210                 215                 220                 


Ala Pro Glu Cys Leu His Pro Cys Arg Val Ser Glu Arg Ser Thr Glu 
225                 230                 235                 240 


Thr Gln Ser Ser Pro Glu Pro His Trp Ser Thr Leu Thr His Ser His 
                245                 250                 255     


Cys Ser Leu Leu Val Asn Arg Ala Leu Pro Gly Ala Asp Pro Gln Asp 
            260                 265                 270         


Gln Gln Ala Gly Arg Arg Leu Ser Ser Gly Ser Val His Ser Ala Ala 
        275                 280                 285             


Asp Ser Ser Trp Pro Thr Thr Pro Ser Gln Arg Gly Phe Leu Gln Arg 
    290                 295                 300                 


Arg Ser Lys Phe Ser Arg Pro Glu Phe Ile Leu Leu Ala Gly Glu Ala 
305                 310                 315                 320 


Pro Met Thr Leu His Leu Pro Gly Ser Val Val Thr Lys Lys Gly Lys 
                325                 330                 335     


Ser Tyr Leu Ala Leu Arg Asp Leu Cys Val Val Leu Leu Asn Gly Gln 
            340                 345                 350         


His Leu Glu Val Lys Cys Asp Val Glu Ser Thr Val Gly Ala Val Phe 
        355                 360                 365             


Asn Ala Val Thr Ser Phe Ala Asn Leu Glu Glu Leu Thr Tyr Phe Gly 
    370                 375                 380                 


Leu Ala Tyr Met Lys Ser Lys Glu Phe Phe Phe Leu Asp Ser Glu Thr 
385                 390                 395                 400 


Arg Leu Cys Lys Ile Ala Pro Glu Gly Trp Arg Glu Gln Pro Gln Lys 
                405                 410                 415     


Thr Ser Met Asn Thr Phe Thr Leu Phe Leu Arg Ile Lys Phe Phe Val 
            420                 425                 430         


Ser His Tyr Gly Leu Leu Gln His Ser Leu Thr Arg His Gln Phe Tyr 
        435                 440                 445             


Leu Gln Leu Arg Lys Asp Ile Leu Glu Glu Arg Leu Tyr Cys Asn Glu 
    450                 455                 460                 


Glu Ile Leu Leu Gln Leu Gly Val Leu Ala Leu Gln Ala Glu Phe Gly 
465                 470                 475                 480 


Asn Tyr Pro Lys Glu Gln Val Glu Ser Lys Pro Tyr Phe His Val Glu 
                485                 490                 495     


Asp Tyr Ile Pro Ala Ser Leu Ile Glu Arg Met Thr Ala Leu Arg Val 
            500                 505                 510         


Gln Val Glu Val Ser Glu Met His Arg Leu Ser Ser Ala Leu Trp Gly 
        515                 520                 525             


Glu Asp Ala Glu Leu Lys Phe Leu Arg Val Thr Gln Gln Leu Pro Glu 
    530                 535                 540                 


Tyr Gly Val Leu Val His Gln Val Phe Ser Glu Lys Arg Arg Pro Glu 
545                 550                 555                 560 


Glu Glu Met Ala Leu Gly Ile Cys Ala Lys Gly Val Ile Val Tyr Glu 
                565                 570                 575     


Val Lys Asn Asn Ser Arg Ile Ala Met Leu Arg Phe Gln Trp Arg Glu 
            580                 585                 590         


Thr Gly Lys Ile Ser Thr Tyr Gln Lys Lys Phe Thr Ile Thr Ser Ser 
        595                 600                 605             


Val Thr Gly Lys Lys His Thr Phe Val Thr Asp Ser Ala Lys Thr Ser 
    610                 615                 620                 


Lys Tyr Leu Leu Asp Leu Cys Ser Ala Gln His Gly Phe Asn Ala Gln 
625                 630                 635                 640 


Met Gly Ser Gly Gln Pro Ser His Val Leu Phe Asp His Asp Lys Phe 
                645                 650                 655     


Val Gln Met Ala Asn Leu Ser Pro Ala His Gln Ala Arg Ser Lys Pro 
            660                 665                 670         


Leu Ile Trp Ile Gln Arg Leu Ser Cys Ser Glu Asn Glu Leu Phe Val 
        675                 680                 685             


Ser Arg Leu Gln Gly Ala Ala Gly Gly Leu Leu Ser Thr Ser Met Asp 
    690                 695                 700                 


Asn Phe Asn Val Asp Gly Ser Lys Glu Ala Gly Ala Glu Gly Ile Gly 
705                 710                 715                 720 


Arg Ser Pro Cys Thr Gly Arg Glu Gln Leu Lys Ser Ala Cys Val Ile 
                725                 730                 735     


Gln Lys Pro Met Thr Trp Asp Ser Leu Ser Gly Pro Pro Val Gln Ser 
            740                 745                 750         


Met His Ala Gly Ser Lys Asn Asn Arg Arg Lys Ser Phe Ile Ala Glu 
        755                 760                 765             


Pro Gly Arg Glu Ile Val Arg Val Thr Leu Lys Arg Asp Pro His Arg 
    770                 775                 780                 


Gly Phe Gly Phe Val Ile Asn Glu Gly Glu Tyr Ser Gly Gln Ala Asp 
785                 790                 795                 800 


Pro Gly Ile Phe Ile Ser Ser Ile Ile Pro Gly Gly Pro Ala Glu Lys 
                805                 810                 815     


Ala Lys Thr Ile Lys Pro Gly Gly Gln Ile Leu Ala Leu Asn His Ile 
            820                 825                 830         


Ser Leu Glu Gly Phe Thr Phe Asn Met Ala Val Arg Met Ile Gln Asn 
        835                 840                 845             


Ser Pro Asp Asn Ile Glu Leu Ile Ile Ser Gln Ser Lys Gly Val Gly 
    850                 855                 860                 


Gly Asn Asn Pro Asp Glu Glu Lys Asn Ser Thr Ala Asn Ser Gly Val 
865                 870                 875                 880 


Ser Ser Thr Asp Ile Leu Ser Phe Gly Tyr Gln Gly Ser Leu Leu Ser 
                885                 890                 895     


His Thr Gln Asp Gln Asp Arg Asn Thr Glu Glu Leu Asp Met Ala Gly 
            900                 905                 910         


Val Gln Ser Leu Val Pro Arg Leu Arg His Gln Leu Ser Phe Leu Pro 
        915                 920                 925             


Leu Lys Gly Ala Gly Ser Ser Cys Pro Pro Ser Pro Pro Glu Ile Ser 
    930                 935                 940                 


Ala Gly Glu Ile Tyr Phe Val Glu Leu Val Lys Glu Asp Gly Thr Leu 
945                 950                 955                 960 


Gly Phe Ser Val Thr Gly Gly Ile Asn Thr Ser Val Pro Tyr Gly Gly 
                965                 970                 975     


Ile Tyr Val Lys Ser Ile Val Pro Gly Gly Pro Ala Ala Lys Glu Gly 
            980                 985                 990         


Gln Ile Leu Gln Gly Asp Arg Leu  Leu Gln Val Asp Gly  Val Ile Leu 
        995                 1000                 1005             


Cys Gly  Leu Thr His Lys Gln  Ala Val Gln Cys Leu  Lys Gly Pro 
    1010                 1015                 1020             


Gly Gln  Val Ala Arg Leu Val  Leu Glu Arg Arg Val  Pro Arg Ser 
    1025                 1030                 1035             


Thr Gln  Gln Cys Pro Ser Ala  Asn Asp Ser Met Gly  Asp Glu Arg 
    1040                 1045                 1050             


Thr Ala  Val Ser Leu Val Thr  Ala Leu Pro Gly Arg  Pro Ser Ser 
    1055                 1060                 1065             


Cys Val  Ser Val Thr Asp Gly  Pro Lys Phe Glu Val  Lys Leu Lys 
    1070                 1075                 1080             


Lys Asn  Ala Asn Gly Leu Gly  Phe Ser Phe Val Gln  Met Glu Lys 
    1085                 1090                 1095             


Glu Ser  Cys Ser His Leu Lys  Ser Asp Leu Val Arg  Ile Lys Arg 
    1100                 1105                 1110             


Leu Phe  Pro Gly Gln Pro Ala  Glu Glu Asn Gly Ala  Ile Ala Ala 
    1115                 1120                 1125             


Gly Asp  Ile Ile Leu Ala Val  Asn Gly Arg Ser Thr  Glu Gly Leu 
    1130                 1135                 1140             


Ile Phe  Gln Glu Val Leu His  Leu Leu Arg Gly Ala  Pro Gln Glu 
    1145                 1150                 1155             


Val Thr  Leu Leu Leu Cys Arg  Pro Pro Pro Gly Ala  Leu Pro Glu 
    1160                 1165                 1170             


Leu Glu  Gln Glu Trp Gln Thr  Pro Glu Leu Ser Ala  Asp Lys Glu 
    1175                 1180                 1185             


Phe Thr  Arg Ala Thr Cys Thr  Asp Ser Cys Thr Ser  Pro Ile Leu 
    1190                 1195                 1200             


Asp Gln  Glu Asp Ser Trp Arg  Asp Ser Ala Ser Pro  Asp Ala Gly 
    1205                 1210                 1215             


Glu Gly  Leu Gly Leu Arg Pro  Glu Ser Ser Gln Lys  Ala Ile Arg 
    1220                 1225                 1230             


Glu Ala  Gln Trp Gly Gln Asn  Arg Glu Arg Pro Trp  Ala Ser Ser 
    1235                 1240                 1245             


Leu Thr  His Ser Pro Glu Ser  His Pro His Leu Cys  Lys Leu His 
    1250                 1255                 1260             


Gln Glu  Arg Asp Glu Ser Thr  Leu Ala Thr Ser Leu  Glu Lys Asp 
    1265                 1270                 1275             


Val Arg  Gln Asn Cys Tyr Ser  Val Cys Asp Ile Met  Arg Leu Gly 
    1280                 1285                 1290             


Arg Tyr  Ser Phe Ser Ser Pro  Leu Thr Arg Leu Ser  Thr Asp Ile 
    1295                 1300                 1305             


Phe 
    


<210>  4189
<211>  1322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRMPD4__Homo_sapiens__NP_055543

<400>  4189

Met Asp Val Phe Ser Phe Val Lys Ile Ala Lys Leu Ser Ser His Arg 
1               5                   10                  15      


Thr Lys Ser Ser Gly Trp Pro Pro Pro Ser Gly Thr Trp Gly Leu Ser 
            20                  25                  30          


Gln Val Pro Pro Tyr Gly Trp Glu Met Thr Ala Asn Arg Asp Gly Arg 
        35                  40                  45              


Asp Tyr Phe Ile Asn His Met Thr Gln Ala Ile Pro Phe Asp Asp Pro 
    50                  55                  60                  


Arg Leu Glu Ser Cys Gln Ile Ile Pro Pro Ala Pro Arg Lys Val Glu 
65                  70                  75                  80  


Met Arg Arg Asp Pro Val Leu Gly Phe Gly Phe Val Ala Gly Ser Glu 
                85                  90                  95      


Lys Pro Val Val Val Arg Ser Val Thr Pro Gly Gly Pro Ser Glu Gly 
            100                 105                 110         


Lys Leu Ile Pro Gly Asp Gln Ile Val Met Ile Asn Asp Glu Pro Val 
        115                 120                 125             


Ser Ala Ala Pro Arg Glu Arg Val Ile Asp Leu Val Arg Ser Cys Lys 
    130                 135                 140                 


Glu Ser Ile Leu Leu Thr Val Ile Gln Pro Tyr Pro Ser Pro Lys Ser 
145                 150                 155                 160 


Ala Phe Ile Ser Ala Ala Lys Lys Ala Arg Leu Lys Ser Asn Pro Val 
                165                 170                 175     


Lys Val Arg Phe Ser Glu Glu Val Ile Ile Asn Gly Gln Val Ser Glu 
            180                 185                 190         


Thr Val Lys Asp Asn Ser Leu Leu Phe Met Pro Asn Val Leu Lys Val 
        195                 200                 205             


Tyr Leu Glu Asn Gly Gln Thr Lys Ser Phe Arg Phe Asp Cys Ser Thr 
    210                 215                 220                 


Ser Ile Lys Asp Val Ile Leu Thr Leu Gln Glu Lys Leu Ser Ile Lys 
225                 230                 235                 240 


Gly Ile Glu His Phe Ser Leu Met Leu Glu Gln Arg Thr Glu Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Leu Leu Leu His Glu Gln Glu Thr Leu Thr Gln Val 
            260                 265                 270         


Thr Gln Arg Pro Ser Ser His Lys Met Arg Cys Leu Phe Arg Ile Ser 
        275                 280                 285             


Phe Val Pro Lys Asp Pro Ile Asp Leu Leu Arg Arg Asp Pro Val Ala 
    290                 295                 300                 


Phe Glu Tyr Leu Tyr Val Gln Ser Cys Asn Asp Val Val Gln Glu Arg 
305                 310                 315                 320 


Phe Gly Pro Glu Leu Lys Tyr Asp Ile Ala Leu Arg Leu Ala Ala Leu 
                325                 330                 335     


Gln Met Tyr Ile Ala Thr Val Thr Thr Lys Gln Thr Gln Lys Ile Ser 
            340                 345                 350         


Leu Lys Tyr Ile Glu Lys Glu Trp Gly Leu Glu Thr Phe Leu Pro Ser 
        355                 360                 365             


Ala Val Leu Gln Ser Met Lys Glu Lys Asn Ile Lys Lys Ala Leu Ser 
    370                 375                 380                 


His Leu Val Lys Ala Asn Gln Asn Leu Val Pro Pro Gly Lys Lys Leu 
385                 390                 395                 400 


Ser Ala Leu Gln Ala Lys Val His Tyr Leu Lys Phe Leu Ser Asp Leu 
                405                 410                 415     


Arg Leu Tyr Gly Gly Arg Val Phe Lys Ala Thr Leu Val Gln Ala Glu 
            420                 425                 430         


Lys Arg Ser Glu Val Thr Leu Leu Val Gly Pro Arg Tyr Gly Ile Ser 
        435                 440                 445             


His Val Ile Asn Thr Lys Thr Asn Leu Val Ala Leu Leu Ala Asp Phe 
    450                 455                 460                 


Ser His Val Asn Arg Ile Glu Met Phe Ser Glu Glu Glu Ser Leu Val 
465                 470                 475                 480 


Arg Val Glu Leu His Val Leu Asp Val Lys Pro Ile Thr Leu Leu Met 
                485                 490                 495     


Glu Ser Ser Asp Ala Met Asn Leu Ala Cys Leu Thr Ala Gly Tyr Tyr 
            500                 505                 510         


Arg Leu Leu Val Asp Ser Arg Arg Ser Ile Phe Asn Met Ala Asn Lys 
        515                 520                 525             


Lys Asn Thr Ala Thr Gln Glu Thr Gly Pro Glu Asn Lys Gly Lys His 
    530                 535                 540                 


Asn Leu Leu Gly Pro Asp Trp Asn Cys Ile Pro Gln Met Thr Thr Phe 
545                 550                 555                 560 


Ile Gly Glu Gly Glu Gln Glu Ala Gln Ile Thr Tyr Ile Asp Ser Lys 
                565                 570                 575     


Gln Lys Thr Val Glu Ile Thr Asp Ser Thr Met Cys Pro Lys Glu His 
            580                 585                 590         


Arg His Leu Tyr Ile Asp Asn Ala Tyr Ser Ser Asp Gly Leu Asn Gln 
        595                 600                 605             


Gln Leu Ser Gln Pro Gly Glu Ala Pro Cys Glu Ala Asp Tyr Arg Ser 
    610                 615                 620                 


Leu Ala Gln Arg Ser Leu Leu Thr Leu Ser Gly Pro Glu Thr Leu Lys 
625                 630                 635                 640 


Lys Ala Gln Glu Ser Pro Arg Gly Ala Lys Val Ser Phe Ile Phe Gly 
                645                 650                 655     


Asp Phe Ala Leu Asp Asp Gly Ile Ser Pro Pro Thr Leu Gly Tyr Glu 
            660                 665                 670         


Thr Leu Leu Asp Glu Gly Pro Glu Met Leu Glu Lys Gln Arg Asn Leu 
        675                 680                 685             


Tyr Ile Gly Ser Ala Asn Asp Met Lys Gly Leu Asp Leu Thr Pro Glu 
    690                 695                 700                 


Ala Glu Gly Ile Gln Phe Val Glu Asn Ser Val Tyr Ala Asn Ile Gly 
705                 710                 715                 720 


Asp Val Lys Ser Phe Gln Ala Ala Glu Gly Ile Glu Glu Pro Leu Leu 
                725                 730                 735     


His Asp Ile Cys Tyr Ala Glu Asn Thr Asp Asp Ala Glu Asp Glu Asp 
            740                 745                 750         


Glu Val Ser Cys Glu Glu Asp Leu Val Val Gly Glu Met Asn Gln Pro 
        755                 760                 765             


Ala Ile Leu Asn Leu Ser Gly Ser Ser Asp Asp Ile Ile Asp Leu Thr 
    770                 775                 780                 


Ser Leu Pro Pro Pro Glu Gly Asp Asp Asn Glu Asp Asp Phe Leu Leu 
785                 790                 795                 800 


Arg Ser Leu Asn Met Ala Ile Ala Ala Pro Pro Pro Gly Phe Arg Asp 
                805                 810                 815     


Ser Ser Asp Glu Glu Asp Ser Gln Ser Gln Ala Ala Ser Phe Pro Glu 
            820                 825                 830         


Asp Lys Glu Lys Gly Ser Ser Leu Gln Asn Asp Glu Ile Pro Val Ser 
        835                 840                 845             


Leu Ile Asp Ala Val Pro Thr Ser Ala Glu Gly Lys Cys Glu Lys Gly 
    850                 855                 860                 


Leu Asp Asn Ala Val Val Ser Thr Leu Gly Ala Leu Glu Ala Leu Ser 
865                 870                 875                 880 


Val Ser Glu Glu Gln Gln Thr Ser Asp Asn Ser Gly Val Ala Ile Leu 
                885                 890                 895     


Arg Ala Tyr Ser Pro Glu Ser Ser Ser Asp Ser Gly Asn Glu Thr Asn 
            900                 905                 910         


Ser Ser Glu Met Thr Glu Ser Ser Glu Leu Ala Thr Ala Gln Lys Gln 
        915                 920                 925             


Ser Glu Asn Leu Ser Arg Met Phe Leu Ala Thr His Glu Gly Tyr His 
    930                 935                 940                 


Pro Leu Ala Glu Glu Gln Thr Glu Phe Pro Ala Ser Lys Thr Pro Ala 
945                 950                 955                 960 


Gly Gly Leu Pro Pro Lys Ser Ser His Ala Leu Ala Ala Arg Pro Ala 
                965                 970                 975     


Thr Asp Leu Pro Pro Lys Val Val Pro Ser Lys Gln Leu Leu His Ser 
            980                 985                 990         


Asp His Met Glu Met Glu Pro Glu  Thr Met Glu Thr Lys  Ser Val Thr 
        995                 1000                 1005             


Asp Tyr  Phe Ser Lys Leu His  Met Gly Ser Val Ala  Tyr Ser Cys 
    1010                 1015                 1020             


Thr Ser  Lys Arg Lys Ser Lys  Leu Ala Asp Gly Glu  Gly Lys Ala 
    1025                 1030                 1035             


Pro Pro  Asn Gly Asn Thr Thr  Gly Lys Lys Gln Gln  Gly Thr Lys 
    1040                 1045                 1050             


Thr Ala  Glu Met Glu Glu Glu  Ala Ser Gly Lys Phe  Gly Thr Val 
    1055                 1060                 1065             


Ser Ser  Arg Asp Ser Gln His  Leu Ser Thr Phe Asn  Leu Glu Arg 
    1070                 1075                 1080             


Thr Ala  Phe Arg Lys Asp Ser  Gln Arg Trp Tyr Val  Ala Thr Glu 
    1085                 1090                 1095             


Gly Gly  Met Ala Glu Lys Ser  Gly Leu Glu Ala Ala  Thr Gly Lys 
    1100                 1105                 1110             


Thr Phe  Pro Arg Ala Ser Gly  Leu Gly Ala Arg Glu  Ala Glu Gly 
    1115                 1120                 1125             


Lys Glu  Glu Gly Ala Pro Asp  Gly Glu Thr Ser Asp  Gly Ser Gly 
    1130                 1135                 1140             


Leu Gly  Gln Gly Asp Arg Phe  Leu Thr Asp Val Thr  Cys Ala Ser 
    1145                 1150                 1155             


Ser Ala  Lys Asp Leu Asp Asn  Pro Glu Asp Ala Asp  Ser Ser Thr 
    1160                 1165                 1170             


Cys Asp  His Pro Ser Lys Leu  Pro Glu Ala Asp Glu  Ser Val Ala 
    1175                 1180                 1185             


Arg Leu  Cys Asp Tyr His Leu  Ala Lys Arg Met Ser  Ser Leu Gln 
    1190                 1195                 1200             


Ser Glu  Gly His Phe Ser Leu  Gln Ser Ser Gln Gly  Ser Ser Val 
    1205                 1210                 1215             


Asp Ala  Gly Cys Gly Thr Gly  Ser Ser Gly Ser Ala  Cys Ala Thr 
    1220                 1225                 1230             


Pro Val  Glu Ser Pro Leu Cys  Pro Ser Leu Gly Lys  His Leu Ile 
    1235                 1240                 1245             


Pro Asp  Ala Ser Gly Lys Gly  Val Asn Tyr Ile Pro  Ser Glu Glu 
    1250                 1255                 1260             


Arg Ala  Pro Gly Leu Pro Asn  His Gly Ala Thr Phe  Lys Glu Leu 
    1265                 1270                 1275             


His Pro  Gln Thr Glu Gly Met  Cys Pro Arg Met Thr  Val Pro Ala 
    1280                 1285                 1290             


Leu His  Thr Ala Ile Asn Thr  Glu Pro Leu Phe Gly  Thr Leu Arg 
    1295                 1300                 1305             


Asp Gly  Cys His Arg Leu Pro  Lys Ile Lys Glu Thr  Thr Val 
    1310                 1315                 1320         


<210>  4190
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRRS1L__Homo_sapiens__NP_055149

<400>  4190

Met Arg Arg Pro Arg Gln Gly Gly Gly Gly Ala Gly Gly Ser Ala Ala 
1               5                   10                  15      


Ala Arg Ala Arg Ala Gly Gly Leu Gly Gly Gly Ser Val Pro Ala Arg 
            20                  25                  30          


Ala Arg Gly Ala Pro Ala Ala Ala Arg Ala Ala Trp Leu Arg Asp Leu 
        35                  40                  45              


Cys Ala Arg Met Ala Arg Pro Pro Arg Gln His Pro Gly Val Trp Ala 
    50                  55                  60                  


Ser Leu Leu Leu Leu Leu Leu Thr Gly Pro Ala Ala Cys Ala Ala Ser 
65                  70                  75                  80  


Pro Ala Asp Asp Gly Ala Gly Pro Gly Gly Arg Gly Pro Arg Gly Arg 
                85                  90                  95      


Ala Arg Gly Asp Thr Gly Ala Asp Glu Ala Val Pro Arg His Asp Ser 
            100                 105                 110         


Ser Tyr Gly Thr Phe Ala Gly Glu Phe Tyr Asp Leu Arg Tyr Leu Ser 
        115                 120                 125             


Glu Glu Gly Tyr Pro Phe Pro Thr Ala Pro Pro Val Asp Pro Phe Ala 
    130                 135                 140                 


Lys Ile Lys Val Asp Asp Cys Gly Lys Thr Lys Gly Cys Phe Arg Tyr 
145                 150                 155                 160 


Gly Lys Pro Gly Cys Asn Ala Glu Thr Cys Asp Tyr Phe Leu Ser Tyr 
                165                 170                 175     


Arg Met Ile Gly Ala Asp Val Glu Phe Glu Leu Ser Ala Asp Thr Asp 
            180                 185                 190         


Gly Trp Val Ala Val Gly Phe Ser Ser Asp Lys Lys Met Gly Gly Asp 
        195                 200                 205             


Asp Val Met Ala Cys Val His Asp Asp Asn Gly Arg Val Arg Ile Gln 
    210                 215                 220                 


His Phe Tyr Asn Val Gly Gln Trp Ala Lys Glu Ile Gln Arg Asn Pro 
225                 230                 235                 240 


Ala Arg Asp Glu Glu Gly Val Phe Glu Asn Asn Arg Val Thr Cys Arg 
                245                 250                 255     


Phe Lys Arg Pro Val Asn Val Pro Arg Asp Glu Thr Ile Val Asp Leu 
            260                 265                 270         


His Leu Ser Trp Tyr Tyr Leu Phe Ala Trp Gly Pro Ala Ile Gln Gly 
        275                 280                 285             


Ser Ile Thr Arg His Asp Ile Asp Ser Pro Pro Ala Ser Glu Arg Val 
    290                 295                 300                 


Val Ser Ile Tyr Lys Tyr Glu Asp Ile Phe Met Pro Ser Ala Ala Tyr 
305                 310                 315                 320 


Gln Thr Phe Ser Ser Pro Phe Cys Leu Leu Leu Ile Val Ala Leu Thr 
                325                 330                 335     


Phe Tyr Leu Leu Met Gly Thr Pro 
            340                 


<210>  4191
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRS2__Homo_sapiens__NP_001265286

<400>  4191

Met Gly Ser Cys Cys Ser Cys Pro Asp Lys Asp Thr Val Pro Asp Asn 
1               5                   10                  15      


His Arg Asn Lys Phe Lys Val Ile Asn Val Asp Asp Asp Gly Asn Glu 
            20                  25                  30          


Leu Gly Ser Gly Ile Met Glu Leu Thr Asp Thr Glu Leu Ile Leu Tyr 
        35                  40                  45              


Thr Arg Lys Arg Asp Ser Val Lys Trp His Tyr Leu Cys Leu Arg Arg 
    50                  55                  60                  


Tyr Gly Tyr Asp Ser Asn Leu Phe Ser Phe Glu Ser Gly Arg Arg Cys 
65                  70                  75                  80  


Gln Thr Gly Gln Gly Ile Phe Ala Phe Lys Cys Ala Arg Ala Glu Glu 
                85                  90                  95      


Leu Phe Asn Met Leu Gln Glu Ile Met Gln Asn Asn Ser Ile Asn Val 
            100                 105                 110         


Val Glu Glu Pro Val Val Glu Arg Asn Asn His Gln Thr Glu Leu Glu 
        115                 120                 125             


Val Pro Arg Thr Pro Arg Thr Pro Thr Thr Pro Gly Phe Ala Ala Gln 
    130                 135                 140                 


Asn Leu Pro Asn Gly Tyr Pro Arg Tyr Pro Ser Phe Gly Asp Ala Ser 
145                 150                 155                 160 


Ser His Pro Ser Ser Arg His Pro Ser Val Gly Ser Ala Arg Leu Pro 
                165                 170                 175     


Ser Val Gly Glu Glu Ser Thr His Pro Leu Leu Val Ala Glu Glu Gln 
            180                 185                 190         


Val His Thr Tyr Val Asn Thr Thr Gly Val Gln Glu Glu Arg Lys Asn 
        195                 200                 205             


Arg Thr Ser Val His Val Pro Leu Glu Ala Arg Val Ser Asn Ala Glu 
    210                 215                 220                 


Ser Ser Thr Pro Lys Glu Glu Pro Ser Ser Ile Glu Asp Arg Asp Pro 
225                 230                 235                 240 


Gln Ile Leu Leu Glu Pro Glu Gly Val Lys Phe Val Leu Gly Pro Thr 
                245                 250                 255     


Pro Val Gln Lys Gln Leu Met Glu Lys Glu Lys Leu Glu Gln Leu Gly 
            260                 265                 270         


Arg Asp Gln Val Ser Gly Ser Gly Ala Asn Asn Thr Glu Trp Asp Thr 
        275                 280                 285             


Gly Tyr Asp Ser Asp Glu Arg Arg Asp Ala Pro Ser Val Asn Lys Leu 
    290                 295                 300                 


Val Tyr Glu Asn Ile Asn Gly Leu Ser Ile Pro Ser Ala Ser Gly Val 
305                 310                 315                 320 


Arg Arg Gly Arg Leu Thr Ser Thr Ser Thr Ser Asp Thr Gln Asn Ile 
                325                 330                 335     


Asn Asn Ser Ala Gln Arg Arg Thr Ala Leu Leu Asn Tyr Glu Asn Leu 
            340                 345                 350         


Pro Ser Leu Pro Pro Val Trp Glu Ala Arg Lys Leu Ser Arg Asp Glu 
        355                 360                 365             


Asp Asp Asn Leu Gly Pro Lys Thr Pro Ser Leu Asn Gly Tyr His Asn 
    370                 375                 380                 


Asn Leu Asp Pro Met His Asn Tyr Val Asn Thr Glu Asn Val Thr Val 
385                 390                 395                 400 


Pro Ala Ser Ala His Lys Ile Glu Tyr Ser Arg Arg Arg Asp Cys Thr 
                405                 410                 415     


Pro Thr Val Phe Asn Phe Asp Ile Arg Arg Pro Ser Leu Glu His Arg 
            420                 425                 430         


Gln Leu Asn Tyr Ile Gln Val Asp Leu Glu Gly Gly Ser Asp Ser Asp 
        435                 440                 445             


Asn Pro Gln Thr Pro Lys Thr Pro Thr Thr Pro Leu Pro Gln Thr Pro 
    450                 455                 460                 


Thr Arg Arg Thr Glu Leu Tyr Ala Val Ile Asp Ile Glu Arg Thr Ala 
465                 470                 475                 480 


Ala Met Ser Asn Leu Gln Lys Ala Leu Pro Arg Asp Asp Gly Thr Ser 
                485                 490                 495     


Arg Lys Thr Arg His Asn Ser Thr Asp Leu Pro Met 
            500                 505             


<210>  4192
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRS3__Homo_sapiens__XP_011512557

<400>  4192

Met Gly Ser Cys Cys Ser Cys Leu Asn Arg Asp Ser Val Pro Asp Asn 
1               5                   10                  15      


His Pro Thr Lys Phe Lys Val Thr Asn Val Asp Asp Glu Gly Val Glu 
            20                  25                  30          


Leu Gly Ser Gly Val Met Glu Leu Thr Gln Ser Glu Leu Val Leu His 
        35                  40                  45              


Leu His Arg Arg Glu Ala Val Arg Trp Pro Tyr Leu Cys Leu Arg Arg 
    50                  55                  60                  


Tyr Gly Tyr Asp Ser Asn Leu Phe Ser Phe Glu Ser Gly Arg Arg Cys 
65                  70                  75                  80  


Gln Thr Gly Gln Gly Ile Phe Ala Phe Lys Cys Ser Arg Ala Glu Glu 
                85                  90                  95      


Ile Phe Asn Leu Leu Gln Asp Leu Met Gln Cys Asn Ser Ile Asn Val 
            100                 105                 110         


Met Glu Glu Pro Val Ile Ile Thr Arg Asn Ser His Pro Ala Glu Leu 
        115                 120                 125             


Asp Leu Pro Arg Ala Pro Gln Pro Pro Asn Ala Leu Gly Tyr Thr Val 
    130                 135                 140                 


Ser Ser Phe Ser Asn Gly Cys Pro Gly Glu Gly Pro Arg Phe Ser Ala 
145                 150                 155                 160 


Pro Arg Arg Leu Ser Thr Ser Ser Leu Arg His Pro Ser Leu Gly Glu 
                165                 170                 175     


Glu Ser Thr His Ala Leu Ile Ala Pro Asp Glu Gln Ser His Thr Tyr 
            180                 185                 190         


Val Asn Thr Pro Ala Ser Glu Asp Asp His Arg Arg Gly Arg His Cys 
        195                 200                 205             


Leu Gln Pro Leu Pro Glu Gly Gln Ala Pro Phe Leu Pro Gln Ala Arg 
    210                 215                 220                 


Gly Pro Asp Gln Arg Asp Pro Gln Val Phe Leu Gln Pro Gly Gln Val 
225                 230                 235                 240 


Lys Phe Val Leu Gly Pro Thr Pro Ala Arg Arg His Met Val Lys Cys 
                245                 250                 255     


Gln Gly Leu Cys Pro Ser Leu His Asp Pro Pro His His Asn Asn Asn 
            260                 265                 270         


Asn Glu Ala Pro Ser Glu Cys Pro Ala Gln Pro Lys Cys Thr Tyr Glu 
        275                 280                 285             


Asn Val Thr Gly Gly Leu Trp Arg Gly Ala Gly Trp Arg Leu Ser Pro 
    290                 295                 300                 


Glu Glu Pro Gly Trp Asn Gly Leu Ala His Arg Arg Ala Ala Leu Leu 
305                 310                 315                 320 


His Tyr Glu Asn Leu Pro Pro Leu Pro Pro Val Trp Glu Ser Gln Ala 
                325                 330                 335     


Gln Gln Leu Gly Gly Glu Ala Gly Asp Asp Gly Asp Ser Arg Asp Gly 
            340                 345                 350         


Leu Thr Pro Ser Ser Asn Gly Phe Pro Asp Gly Glu Glu Asp Glu Thr 
        355                 360                 365             


Pro Leu Gln Lys Pro Thr Ser Thr Arg Ala Ala Ile Arg Ser His Gly 
    370                 375                 380                 


Ser Phe Pro Val Pro Leu Thr Arg Arg Arg Gly Ser Pro Arg Val Phe 
385                 390                 395                 400 


Asn Phe Asp Phe Arg Arg Pro Gly Pro Glu Pro Pro Arg Gln Leu Asn 
                405                 410                 415     


Tyr Ile Gln Val Glu Leu Lys Gly Trp Gly Gly Asp Arg Pro Lys Gly 
            420                 425                 430         


Pro Gln Asn Pro Ser Ser Pro Gln Ala Pro Met Pro Thr Thr His Pro 
        435                 440                 445             


Ala Arg Ser Ser Asp Ser Tyr Ala Val Ile Asp Leu Lys Lys Thr Val 
    450                 455                 460                 


Ala Met Ser Asn Leu Gln Arg Ala Leu Pro Arg Asp Asp Gly Thr Ala 
465                 470                 475                 480 


Arg Lys Thr Arg His Asn Ser Thr Asp Leu Pro Leu 
                485                 490         


<210>  4193
<211>  3013
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRY__Homo_sapiens__NP_075463

<400>  4193

Met Ala Ser Gln Gln Asp Ser Gly Phe Phe Glu Ile Ser Ile Lys Tyr 
1               5                   10                  15      


Leu Leu Lys Ser Trp Ser Asn Thr Ser Pro Val Gly Asn Gly Tyr Ile 
            20                  25                  30          


Lys Pro Pro Val Pro Pro Ala Ser Gly Thr His Arg Glu Lys Gly Pro 
        35                  40                  45              


Pro Thr Met Leu Pro Ile Asn Val Asp Pro Asp Ser Lys Pro Gly Glu 
    50                  55                  60                  


Tyr Val Leu Lys Ser Leu Phe Val Asn Phe Thr Thr Gln Ala Glu Arg 
65                  70                  75                  80  


Lys Ile Arg Ile Ile Met Ala Glu Pro Leu Glu Lys Pro Leu Thr Lys 
                85                  90                  95      


Ser Leu Gln Arg Gly Glu Asp Pro Gln Phe Asp Gln Val Ile Ser Ser 
            100                 105                 110         


Met Ser Ser Leu Ser Glu Tyr Cys Leu Pro Ser Ile Leu Arg Thr Leu 
        115                 120                 125             


Phe Asp Trp Tyr Lys Arg Gln Asn Gly Ile Glu Asp Glu Ser His Glu 
    130                 135                 140                 


Tyr Arg Pro Arg Thr Ser Asn Lys Ser Lys Ser Asp Glu Gln Gln Arg 
145                 150                 155                 160 


Asp Tyr Leu Met Glu Arg Arg Asp Leu Ala Ile Asp Phe Ile Phe Ser 
                165                 170                 175     


Leu Val Leu Ile Glu Val Leu Lys Gln Ile Pro Leu His Pro Val Ile 
            180                 185                 190         


Asp Ser Leu Ile His Asp Val Ile Asn Leu Ala Phe Lys His Phe Lys 
        195                 200                 205             


Tyr Lys Glu Gly Tyr Leu Gly Pro Asn Thr Gly Asn Met His Ile Val 
    210                 215                 220                 


Ala Asp Leu Tyr Ala Glu Val Ile Gly Val Leu Ala Gln Ala Lys Phe 
225                 230                 235                 240 


Pro Ala Val Lys Lys Lys Phe Met Ala Glu Leu Lys Glu Leu Arg His 
                245                 250                 255     


Lys Glu Gln Asn Pro Tyr Val Val Gln Ser Ile Ile Ser Leu Ile Met 
            260                 265                 270         


Gly Met Lys Phe Phe Arg Ile Lys Met Tyr Pro Val Glu Asp Phe Glu 
        275                 280                 285             


Ala Ser Leu Gln Phe Met Gln Glu Cys Ala His Tyr Phe Leu Glu Val 
    290                 295                 300                 


Lys Asp Lys Asp Ile Lys His Ala Leu Ala Gly Leu Phe Val Glu Ile 
305                 310                 315                 320 


Leu Val Pro Val Ala Ala Ala Val Lys Asn Glu Val Asn Val Pro Cys 
                325                 330                 335     


Leu Arg Asn Phe Val Glu Ser Leu Tyr Asp Thr Thr Leu Glu Leu Ser 
            340                 345                 350         


Ser Arg Lys Lys His Ser Leu Ala Leu Tyr Pro Leu Val Thr Cys Leu 
        355                 360                 365             


Leu Cys Val Ser Gln Lys Gln Leu Phe Leu Asn Arg Trp His Ile Phe 
    370                 375                 380                 


Leu Asn Asn Cys Leu Ser Asn Leu Lys Asn Lys Asp Pro Lys Met Ala 
385                 390                 395                 400 


Arg Val Ala Leu Glu Ser Leu Tyr Arg Leu Leu Trp Val Tyr Met Ile 
                405                 410                 415     


Arg Ile Lys Cys Glu Ser Asn Thr Ala Thr Gln Ser Arg Leu Ile Thr 
            420                 425                 430         


Ile Ile Thr Thr Leu Phe Pro Lys Gly Ser Arg Gly Val Val Pro Arg 
        435                 440                 445             


Asp Met Pro Leu Asn Ile Phe Val Lys Ile Ile Gln Phe Ile Ala Gln 
    450                 455                 460                 


Glu Arg Leu Asp Phe Ala Met Lys Glu Ile Ile Phe Asp Phe Leu Cys 
465                 470                 475                 480 


Val Gly Lys Pro Ala Lys Ala Phe Ser Leu Asn Pro Glu Arg Met Asn 
                485                 490                 495     


Ile Gly Leu Arg Ala Phe Leu Val Ile Ala Asp Ser Leu Gln Gln Lys 
            500                 505                 510         


Asp Gly Glu Pro Pro Met Pro Val Thr Gly Ala Val Leu Pro Ser Gly 
        515                 520                 525             


Asn Thr Leu Arg Val Lys Lys Thr Tyr Leu Ser Lys Thr Leu Thr Glu 
    530                 535                 540                 


Glu Glu Ala Lys Met Ile Gly Met Ser Leu Tyr Tyr Ser Gln Val Arg 
545                 550                 555                 560 


Lys Ala Val Asp Asn Ile Leu Arg His Leu Asp Lys Glu Val Gly Arg 
                565                 570                 575     


Cys Met Met Leu Thr Asn Val Gln Met Leu Asn Lys Glu Pro Glu Asp 
            580                 585                 590         


Met Ile Thr Gly Glu Arg Lys Pro Lys Ile Asp Leu Phe Arg Thr Cys 
        595                 600                 605             


Val Ala Ala Ile Pro Arg Leu Leu Pro Asp Gly Met Ser Lys Leu Glu 
    610                 615                 620                 


Leu Ile Asp Leu Leu Ala Arg Leu Ser Ile His Met Asp Asp Glu Leu 
625                 630                 635                 640 


Arg His Ile Ala Gln Asn Ser Leu Gln Gly Leu Leu Val Asp Phe Ser 
                645                 650                 655     


Asp Trp Arg Glu Asp Val Leu Phe Gly Phe Thr Asn Phe Leu Leu Arg 
            660                 665                 670         


Glu Val Asn Asp Met His His Thr Leu Leu Asp Ser Ser Leu Lys Leu 
        675                 680                 685             


Leu Leu Gln Leu Leu Thr Gln Trp Lys Leu Val Ile Gln Thr Gln Gly 
    690                 695                 700                 


Lys Val Tyr Glu Gln Ala Asn Lys Ile Arg Asn Ser Glu Leu Ile Ala 
705                 710                 715                 720 


Asn Gly Ser Ser His Arg Ile Gln Ser Glu Arg Gly Pro His Cys Ser 
                725                 730                 735     


Val Leu His Ala Val Glu Gly Phe Ala Leu Val Leu Leu Cys Ser Phe 
            740                 745                 750         


Gln Val Ala Thr Arg Lys Leu Ser Val Leu Ile Leu Lys Glu Ile Arg 
        755                 760                 765             


Ala Leu Phe Ile Ala Leu Gly Gln Pro Glu Asp Asp Asp Arg Pro Met 
    770                 775                 780                 


Ile Asp Val Met Asp Gln Leu Ser Ser Ser Ile Leu Glu Ser Phe Ile 
785                 790                 795                 800 


His Val Ala Val Ser Asp Ser Ala Thr Leu Pro Leu Thr His Asn Val 
                805                 810                 815     


Asp Leu Gln Trp Leu Val Glu Trp Asn Ala Val Leu Val Asn Ser His 
            820                 825                 830         


Tyr Asp Val Lys Ser Pro Ser His Val Trp Ile Phe Ala Gln Ser Val 
        835                 840                 845             


Lys Asp Pro Trp Val Leu Cys Leu Phe Ser Phe Leu Arg Gln Glu Asn 
    850                 855                 860                 


Leu Pro Lys His Cys Pro Thr Ala Leu Ser Tyr Ala Trp Pro Tyr Ala 
865                 870                 875                 880 


Phe Thr Arg Leu Gln Ser Val Met Pro Leu Val Asp Pro Asn Ser Pro 
                885                 890                 895     


Ile Asn Ala Lys Lys Thr Ser Thr Ala Gly Ser Gly Asp Asn Tyr Val 
            900                 905                 910         


Thr Leu Trp Arg Asn Tyr Leu Ile Leu Cys Phe Gly Val Ala Lys Pro 
        915                 920                 925             


Ser Ile Met Ser Pro Gly His Leu Arg Ala Ser Thr Pro Glu Ile Met 
    930                 935                 940                 


Ala Thr Thr Pro Asp Gly Thr Val Ser Tyr Asp Asn Lys Ala Ile Gly 
945                 950                 955                 960 


Thr Pro Ser Val Gly Val Leu Leu Lys Gln Leu Val Pro Leu Met Arg 
                965                 970                 975     


Leu Glu Ser Ile Glu Ile Thr Glu Ser Leu Val Leu Gly Phe Gly Arg 
            980                 985                 990         


Thr Asn Ser Leu Val Phe Arg Glu  Leu Val Glu Glu Leu  His Pro Leu 
        995                 1000                 1005             


Met Lys  Glu Ala Leu Glu Arg  Arg Pro Glu Asn Lys  Lys Arg Arg 
    1010                 1015                 1020             


Glu Arg  Arg Asp Leu Leu Arg  Leu Gln Leu Leu Arg  Ile Phe Glu 
    1025                 1030                 1035             


Leu Leu  Ala Asp Ala Gly Val  Ile Ser Asp Ser Thr  Asn Gly Ala 
    1040                 1045                 1050             


Leu Glu  Arg Asp Thr Leu Ala  Leu Gly Ala Leu Phe  Leu Glu Tyr 
    1055                 1060                 1065             


Val Asp  Leu Thr Arg Met Leu  Leu Glu Ala Glu Asn  Asp Lys Glu 
    1070                 1075                 1080             


Val Glu  Ile Leu Lys Asp Ile  Arg Ala His Phe Ser  Ala Met Val 
    1085                 1090                 1095             


Ala Asn  Leu Ile Gln Cys Val  Pro Val His His Arg  Arg Phe Leu 
    1100                 1105                 1110             


Phe Pro  Gln Gln Ser Leu Arg  His His Leu Phe Ile  Leu Phe Ser 
    1115                 1120                 1125             


Gln Trp  Ala Gly Pro Phe Ser  Ile Met Phe Thr Pro  Leu Asp Arg 
    1130                 1135                 1140             


Tyr Ser  Asp Arg Asn His Gln  Ile Thr Arg Tyr Gln  Tyr Cys Ala 
    1145                 1150                 1155             


Leu Lys  Ala Met Ser Ala Val  Leu Cys Cys Gly Pro  Val Phe Asp 
    1160                 1165                 1170             


Asn Val  Gly Leu Ser Pro Asp  Gly Tyr Leu Tyr Lys  Trp Leu Asp 
    1175                 1180                 1185             


Asn Ile  Leu Ala Cys Gln Asp  Leu Arg Val His Gln  Leu Gly Cys 
    1190                 1195                 1200             


Glu Val  Val Val Leu Leu Leu  Glu Leu Asn Pro Asp  Gln Ile Asn 
    1205                 1210                 1215             


Leu Phe  Asn Trp Ala Ile Asp  Arg Cys Tyr Thr Gly  Ser Tyr Gln 
    1220                 1225                 1230             


Leu Ala  Ser Gly Cys Phe Lys  Ala Ile Ala Thr Val  Cys Gly Ser 
    1235                 1240                 1245             


Arg Asn  Tyr Pro Phe Asp Ile  Val Thr Leu Leu Asn  Leu Val Leu 
    1250                 1255                 1260             


Phe Lys  Ala Ser Asp Thr Asn  Arg Glu Ile Tyr Glu  Ile Ser Met 
    1265                 1270                 1275             


Gln Leu  Met Gln Ile Leu Glu  Ala Lys Leu Phe Val  Tyr Ser Lys 
    1280                 1285                 1290             


Lys Val  Ala Glu Gln Arg Pro  Gly Ser Ile Leu Tyr  Gly Thr His 
    1295                 1300                 1305             


Gly Pro  Leu Pro Pro Leu Tyr  Ser Val Ser Leu Ala  Leu Leu Ser 
    1310                 1315                 1320             


Cys Glu  Leu Ala Arg Met Tyr  Pro Glu Leu Thr Leu  Pro Leu Phe 
    1325                 1330                 1335             


Ser Glu  Val Ser Gln Arg Phe  Pro Thr Thr His Pro  Asn Gly Arg 
    1340                 1345                 1350             


Gln Ile  Met Leu Thr Tyr Leu  Leu Pro Trp Leu His  Asn Ile Glu 
    1355                 1360                 1365             


Leu Val  Asp Ser Arg Leu Leu  Leu Pro Gly Ser Ser  Pro Ser Ser 
    1370                 1375                 1380             


Pro Glu  Asp Glu Val Lys Asp  Arg Glu Gly Asp Val  Thr Ala Ser 
    1385                 1390                 1395             


His Gly  Leu Arg Gly Asn Gly  Trp Gly Ser Pro Glu  Ala Thr Ser 
    1400                 1405                 1410             


Leu Val  Leu Asn Asn Leu Met  Tyr Met Thr Ala Lys  Tyr Gly Asp 
    1415                 1420                 1425             


Glu Val  Pro Gly Pro Glu Met  Glu Asn Ala Trp Asn  Ala Leu Ala 
    1430                 1435                 1440             


Asn Asn  Glu Lys Trp Ser Asn  Asn Leu Arg Ile Thr  Leu Gln Phe 
    1445                 1450                 1455             


Leu Ile  Ser Leu Cys Gly Val  Ser Ser Asp Thr Val  Leu Leu Pro 
    1460                 1465                 1470             


Tyr Ile  Lys Lys Val Ala Ile  Tyr Leu Cys Arg Asn  Asn Thr Ile 
    1475                 1480                 1485             


Gln Thr  Met Glu Glu Leu Leu  Phe Glu Leu Gln Gln  Thr Glu Pro 
    1490                 1495                 1500             


Val Asn  Pro Ile Val Gln His  Cys Asp Asn Pro Pro  Phe Tyr Arg 
    1505                 1510                 1515             


Phe Thr  Ala Ser Ser Lys Ala  Ser Ala Ala Ala Ser  Gly Thr Thr 
    1520                 1525                 1530             


Ser Ser  Ser Asn Thr Val Val  Ala Gly Gln Glu Asn  Phe Pro Asp 
    1535                 1540                 1545             


Ala Glu  Glu Asn Lys Ile Leu  Lys Glu Ser Asp Glu  Arg Phe Ser 
    1550                 1555                 1560             


Asn Val  Ile Arg Ala His Thr  Arg Leu Glu Ser Arg  Tyr Ser Asn 
    1565                 1570                 1575             


Ser Ser  Gly Gly Ser Tyr Asp  Glu Asp Lys Asn Asp  Pro Ile Ser 
    1580                 1585                 1590             


Pro Tyr  Thr Gly Trp Leu Leu  Thr Ile Thr Glu Thr  Lys Gln Pro 
    1595                 1600                 1605             


Gln Pro  Leu Pro Met Pro Cys  Thr Gly Gly Cys Trp  Ala Pro Leu 
    1610                 1615                 1620             


Val Asp  Tyr Leu Pro Glu Thr  Ile Thr Pro Arg Gly  Pro Leu His 
    1625                 1630                 1635             


Arg Cys  Asn Ile Ala Val Ile  Phe Met Thr Glu Met  Val Val Asp 
    1640                 1645                 1650             


His Ser  Val Arg Glu Asp Trp  Ala Leu His Leu Pro  Leu Leu Leu 
    1655                 1660                 1665             


His Ala  Val Phe Leu Gly Leu  Asp His Tyr Arg Pro  Glu Val Phe 
    1670                 1675                 1680             


Glu His  Ser Lys Lys Leu Leu  Leu His Leu Leu Ile  Ala Leu Ser 
    1685                 1690                 1695             


Cys Asn  Ser Asn Phe His Ser  Ile Ala Ser Val Leu  Leu Gln Thr 
    1700                 1705                 1710             


Arg Glu  Met Gly Glu Ala Lys  Thr Leu Thr Val Gln  Pro Ala Tyr 
    1715                 1720                 1725             


Gln Pro  Glu Tyr Leu Tyr Thr  Gly Gly Phe Asp Phe  Leu Arg Glu 
    1730                 1735                 1740             


Asp Gln  Ser Ser Pro Val Pro  Asp Ser Gly Leu Ser  Ser Ser Ser 
    1745                 1750                 1755             


Thr Ser  Ser Ser Ile Ser Leu  Gly Gly Ser Ser Gly  Asn Leu Pro 
    1760                 1765                 1770             


Gln Met  Thr Gln Glu Val Glu  Asp Val Asp Thr Ala  Ala Glu Thr 
    1775                 1780                 1785             


Asp Glu  Lys Ala Asn Lys Leu  Ile Glu Phe Leu Thr  Thr Arg Ala 
    1790                 1795                 1800             


Phe Gly  Pro Leu Trp Cys His  Glu Asp Ile Thr Pro  Lys Asn Gln 
    1805                 1810                 1815             


Asn Ser  Lys Ser Ala Glu Gln  Leu Thr Asn Phe Leu  Arg His Val 
    1820                 1825                 1830             


Val Ser  Val Phe Lys Asp Ser  Lys Ser Gly Phe His  Leu Glu His 
    1835                 1840                 1845             


Gln Leu  Ser Glu Val Ala Leu  Gln Thr Ala Leu Ala  Ser Ser Ser 
    1850                 1855                 1860             


Arg His  Tyr Ala Gly Arg Ser  Phe Gln Ile Phe Arg  Ala Leu Lys 
    1865                 1870                 1875             


Gln Pro  Leu Ser Ala His Ala  Leu Ser Asp Leu Leu  Ser Arg Leu 
    1880                 1885                 1890             


Val Glu  Val Ile Gly Glu His  Gly Asp Glu Ile Gln  Gly Tyr Val 
    1895                 1900                 1905             


Met Glu  Ala Leu Leu Thr Leu  Glu Ala Ala Val Asp  Asn Leu Ser 
    1910                 1915                 1920             


Asp Cys  Leu Lys Asn Ser Asp  Leu Leu Thr Val Leu  Ser Arg Ser 
    1925                 1930                 1935             


Ser Ser  Pro Asp Leu Ser Ser  Ser Ser Lys Leu Thr  Ala Ser Arg 
    1940                 1945                 1950             


Lys Ser  Thr Gly Gln Leu Asn  Met Asn Pro Gly Thr  Thr Ser Gly 
    1955                 1960                 1965             


Asn Thr  Ala Thr Ala Glu Arg  Ser Arg His Gln Arg  Ser Phe Ser 
    1970                 1975                 1980             


Val Pro  Lys Lys Phe Gly Val  Ile Asp Arg Ser Ser  Asp Pro Pro 
    1985                 1990                 1995             


Arg Ser  Ala Thr Leu Asp Arg  Ile Gln Ala Cys Thr  Gln Gln Gly 
    2000                 2005                 2010             


Leu Ser  Ser Lys Thr Arg Ser  Ser Ser Ser Leu Lys  Asp Ser Leu 
    2015                 2020                 2025             


Thr Asp  Pro Ser His Ile Asn  His Pro Thr Asn Leu  Leu Ala Thr 
    2030                 2035                 2040             


Ile Phe  Trp Val Thr Val Ala  Leu Met Glu Ser Asp  Phe Glu Phe 
    2045                 2050                 2055             


Glu Tyr  Leu Met Ala Leu Arg  Leu Leu Ser Arg Leu  Leu Ala His 
    2060                 2065                 2070             


Met Pro  Leu Asp Lys Ala Glu  Asn Arg Glu Lys Leu  Glu Lys Leu 
    2075                 2080                 2085             


Gln Ala  Gln Leu Lys Trp Ala  Asp Phe Ser Gly Leu  Gln Gln Leu 
    2090                 2095                 2100             


Leu Leu  Lys Gly Phe Thr Ser  Leu Thr Thr Thr Asp  Leu Thr Leu 
    2105                 2110                 2115             


Gln Leu  Phe Ser Leu Leu Thr  Pro Val Ser Lys Ile  Ser Met Val 
    2120                 2125                 2130             


Asp Ala  Ser His Ala Ile Gly  Phe Pro Leu Asn Val  Leu Cys Leu 
    2135                 2140                 2145             


Leu Pro  Gln Leu Ile Gln His  Phe Glu Asn Pro Asn  Gln Phe Cys 
    2150                 2155                 2160             


Lys Asp  Ile Ala Glu Arg Ile  Ala Gln Val Cys Leu  Glu Glu Lys 
    2165                 2170                 2175             


Asn Pro  Lys Leu Ser Asn Leu  Ala His Val Met Thr  Leu Tyr Lys 
    2180                 2185                 2190             


Thr His  Ser Tyr Thr Arg Asp  Cys Ala Thr Trp Val  Asn Val Val 
    2195                 2200                 2205             


Cys Arg  Tyr Leu His Glu Ala  Tyr Ala Asp Ile Thr  Leu Asn Met 
    2210                 2215                 2220             


Val Thr  Tyr Leu Ala Glu Leu  Leu Glu Lys Gly Leu  Pro Ser Val 
    2225                 2230                 2235             


Gln Gln  Pro Leu Leu Gln Val  Ile Tyr Ser Leu Leu  Ser Tyr Met 
    2240                 2245                 2250             


Asp Leu  Ser Val Val Pro Val  Lys Gln Phe Asn Val  Glu Val Leu 
    2255                 2260                 2265             


Lys Thr  Ile Glu Lys Tyr Val  Gln Ser Val His Trp  Arg Glu Ala 
    2270                 2275                 2280             


Leu Asn  Ile Leu Lys Leu Val  Val Ser Arg Ser Ala  Ser Leu Val 
    2285                 2290                 2295             


Leu Pro  Ser Tyr Gln His Ser  Asp Leu Ser Lys Ile  Glu Ile His 
    2300                 2305                 2310             


Arg Val  Trp Thr Ser Ala Ser  Lys Glu Leu Pro Gly  Lys Thr Leu 
    2315                 2320                 2325             


Asp Phe  His Phe Asp Ile Ser  Glu Thr Pro Ile Ile  Gly Arg Arg 
    2330                 2335                 2340             


Tyr Asp  Glu Leu Gln Asn Ser  Ser Gly Arg Asp Gly  Lys Pro Arg 
    2345                 2350                 2355             


Ala Met  Ala Val Thr Arg Ser  Thr Ser Ser Thr Ser  Ser Gly Ser 
    2360                 2365                 2370             


Asn Ser  Asn Val Leu Val Pro  Val Ser Trp Lys Arg  Pro Gln Tyr 
    2375                 2380                 2385             


Ser Gln  Lys Arg Thr Lys Glu  Lys Leu Val His Val  Leu Ser Leu 
    2390                 2395                 2400             


Cys Gly  Gln Glu Val Gly Leu  Ser Lys Asn Pro Ser  Val Ile Phe 
    2405                 2410                 2415             


Ser Ser  Cys Gly Asp Leu Asp  Leu Leu Glu His Gln  Thr Ser Leu 
    2420                 2425                 2430             


Val Ser  Ser Glu Asp Gly Ala  Arg Glu Gln Glu Asn  Met Asp Asp 
    2435                 2440                 2445             


Thr Asn  Ser Glu Gln Gln Phe  Arg Val Phe Arg Asp  Phe Asp Phe 
    2450                 2455                 2460             


Leu Asp  Val Glu Leu Glu Asp  Gly Glu Gly Glu Ser  Met Asp Asn 
    2465                 2470                 2475             


Phe Asn  Trp Gly Val Arg Arg  Arg Ser Leu Asp Ser  Leu Asp Lys 
    2480                 2485                 2490             


Cys Asp  Met Gln Ile Leu Glu  Glu Arg Gln Leu Ser  Gly Ser Thr 
    2495                 2500                 2505             


Pro Ser  Leu Asn Lys Met His  His Glu Asp Ser Asp  Glu Ser Ser 
    2510                 2515                 2520             


Glu Glu  Glu Asp Leu Thr Ala  Ser Gln Ile Leu Glu  His Ser Asp 
    2525                 2530                 2535             


Leu Ile  Met Thr Leu Ser Pro  Ser Glu Glu Thr Asn  Pro Met Glu 
    2540                 2545                 2550             


Leu Leu  Thr Thr Ala Cys Asp  Ser Thr Pro Ala Glu  Pro His Ser 
    2555                 2560                 2565             


Phe Asn  Thr Arg Met Ser Ser  Phe Asp Ala Ser Leu  Pro Asp Met 
    2570                 2575                 2580             


Asn Asn  Leu Gln Ile Ser Glu  Gly Ser Lys Ala Glu  Ala Val Arg 
    2585                 2590                 2595             


Glu Glu  Glu Asp Thr Thr Val  His Glu Asp Asp Leu  Ser Ser Ser 
    2600                 2605                 2610             


Ile Asn  Glu Leu Pro Ala Ala  Phe Glu Cys Ser Asp  Ser Phe Ser 
    2615                 2620                 2625             


Leu Asp  Met Thr Glu Gly Glu  Glu Lys Gly Asn Arg  Ala Leu Asp 
    2630                 2635                 2640             


Gln Phe  Thr Leu Ala Ser Phe  Gly Glu Gly Asp Arg  Gly Val Ser 
    2645                 2650                 2655             


Pro Pro  Pro Ser Pro Phe Phe  Ser Ala Ile Leu Ala  Ala Phe Gln 
    2660                 2665                 2670             


Pro Ala  Ala Cys Asp Asp Ala  Glu Glu Ala Trp Arg  Ser His Ile 
    2675                 2680                 2685             


Asn Gln  Leu Met Cys Asp Ser  Asp Gly Ser Cys Ala  Val Tyr Thr 
    2690                 2695                 2700             


Phe His  Val Phe Ser Ser Leu  Phe Lys Asn Ile Gln  Lys Arg Phe 
    2705                 2710                 2715             


Cys Phe  Leu Thr Cys Asp Ala  Ala Ser Tyr Leu Gly  Asp Asn Leu 
    2720                 2725                 2730             


Arg Gly  Ile Gly Ser Lys Phe  Val Ser Ser Ser Gln  Met Leu Thr 
    2735                 2740                 2745             


Ser Cys  Ser Glu Cys Pro Thr  Leu Phe Val Asp Ala  Glu Thr Leu 
    2750                 2755                 2760             


Leu Ser  Cys Gly Leu Leu Asp  Lys Leu Lys Phe Ser  Val Leu Glu 
    2765                 2770                 2775             


Leu Gln  Glu Tyr Leu Asp Thr  Tyr Asn Asn Arg Lys  Glu Ala Thr 
    2780                 2785                 2790             


Leu Ser  Trp Leu Ala Asn Cys  Lys Ala Thr Phe Ala  Gly Gly Ser 
    2795                 2800                 2805             


Arg Asp  Gly Val Ile Thr Cys  Gln Pro Gly Asp Ser  Glu Glu Lys 
    2810                 2815                 2820             


Gln Leu  Glu Leu Cys Gln Arg  Leu Tyr Lys Leu His  Phe Gln Leu 
    2825                 2830                 2835             


Leu Leu  Leu Phe Gln Ser Tyr  Cys Lys Leu Ile Gly  Gln Val His 
    2840                 2845                 2850             


Glu Val  Ser Ser Met Pro Glu  Leu Leu Asn Met Ser  Arg Glu Leu 
    2855                 2860                 2865             


Ser Asp  Leu Lys Lys His Leu  Lys Glu Ala Ser Ala  Val Ile Ala 
    2870                 2875                 2880             


Ala Asp  Pro Leu Tyr Ser Asp  Gly Ala Trp Ser Glu  Pro Thr Phe 
    2885                 2890                 2895             


Thr Ser  Thr Glu Ala Ala Ile  Gln Ser Met Leu Glu  Cys Leu Lys 
    2900                 2905                 2910             


Asn Asn  Glu Leu Gly Lys Ala  Leu Arg Gln Ile Arg  Glu Cys Arg 
    2915                 2920                 2925             


Ser Leu  Trp Pro Asn Asp Ile  Phe Gly Ser Ser Ser  Asp Asp Glu 
    2930                 2935                 2940             


Val Gln  Thr Leu Leu Asn Ile  Tyr Phe Arg His Gln  Thr Leu Gly 
    2945                 2950                 2955             


Gln Thr  Gly Thr Tyr Ala Leu  Val Gly Ser Asn Gln  Ser Leu Thr 
    2960                 2965                 2970             


Glu Ile  Cys Thr Lys Leu Met  Glu Leu Asn Met Glu  Ile Arg Asp 
    2975                 2980                 2985             


Met Ile  Arg Arg Ala Gln Ser  Tyr Arg Val Leu Thr  Thr Phe Leu 
    2990                 2995                 3000             


Pro Asp  Ser Ser Val Ser Gly  Thr Ser Leu 
    3005                 3010             


<210>  4194
<211>  3013
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRYL__Homo_sapiens__NP_055845

<400>  4194

Met Ser Asn Ile Thr Ile Asp Pro Asp Val Lys Pro Gly Glu Tyr Val 
1               5                   10                  15      


Ile Lys Ser Leu Phe Ala Glu Phe Ala Val Gln Ala Glu Lys Lys Ile 
            20                  25                  30          


Glu Val Val Met Ala Glu Pro Leu Glu Lys Leu Leu Ser Arg Ser Leu 
        35                  40                  45              


Gln Arg Gly Glu Asp Leu Gln Phe Asp Gln Leu Ile Ser Ser Met Ser 
    50                  55                  60                  


Ser Val Ala Glu His Cys Leu Pro Ser Leu Leu Arg Thr Leu Phe Asp 
65                  70                  75                  80  


Trp Tyr Arg Arg Gln Asn Gly Thr Glu Asp Glu Ser Tyr Glu Tyr Arg 
                85                  90                  95      


Pro Arg Ser Ser Thr Lys Ser Lys Gly Asp Glu Gln Gln Arg Glu Arg 
            100                 105                 110         


Asp Tyr Leu Leu Glu Arg Arg Asp Leu Ala Val Asp Phe Ile Phe Cys 
        115                 120                 125             


Leu Val Leu Val Glu Val Leu Lys Gln Ile Pro Val His Pro Val Pro 
    130                 135                 140                 


Asp Pro Leu Val His Glu Val Leu Asn Leu Ala Phe Lys His Phe Lys 
145                 150                 155                 160 


His Lys Glu Gly Tyr Ser Gly Thr Asn Thr Gly Asn Val His Ile Ile 
                165                 170                 175     


Ala Asp Leu Tyr Ala Glu Val Ile Gly Val Leu Ala Gln Ser Lys Phe 
            180                 185                 190         


Gln Ala Val Arg Lys Lys Phe Val Thr Glu Leu Lys Glu Leu Arg Gln 
        195                 200                 205             


Lys Glu Gln Ser Pro His Val Val Gln Ser Val Ile Ser Leu Ile Met 
    210                 215                 220                 


Gly Met Lys Phe Phe Arg Val Lys Met Tyr Pro Val Glu Asp Phe Glu 
225                 230                 235                 240 


Ala Ser Phe Gln Phe Met Gln Glu Cys Ala Gln Tyr Phe Leu Glu Val 
                245                 250                 255     


Lys Asp Lys Asp Ile Lys His Ala Leu Ala Gly Leu Phe Val Glu Ile 
            260                 265                 270         


Leu Ile Pro Val Ala Ala Ala Val Lys Asn Glu Val Asn Val Pro Cys 
        275                 280                 285             


Leu Lys Asn Phe Val Glu Met Leu Tyr Gln Thr Thr Phe Glu Leu Ser 
    290                 295                 300                 


Ser Arg Lys Lys His Ser Leu Ala Leu Tyr Pro Leu Ile Thr Cys Leu 
305                 310                 315                 320 


Leu Cys Val Ser Gln Lys Gln Phe Phe Leu Asn Asn Trp His Ile Phe 
                325                 330                 335     


Leu Gln Asn Cys Leu Ser His Leu Lys Asn Lys Asp Pro Lys Met Ser 
            340                 345                 350         


Arg Val Ala Leu Glu Ser Leu Tyr Arg Leu Leu Trp Val Tyr Val Ile 
        355                 360                 365             


Arg Ile Lys Cys Glu Ser Asn Thr Val Thr Gln Ser Arg Leu Met Ser 
    370                 375                 380                 


Ile Val Ser Ala Leu Phe Pro Lys Gly Ser Arg Ser Val Val Pro Arg 
385                 390                 395                 400 


Asp Thr Pro Leu Asn Ile Phe Val Lys Ile Ile Gln Phe Ile Ala Gln 
                405                 410                 415     


Glu Arg Leu Asp Phe Ala Met Lys Glu Ile Ile Phe Asp Leu Leu Ser 
            420                 425                 430         


Val Gly Lys Ser Thr Lys Thr Phe Thr Ile Asn Pro Glu Arg Met Asn 
        435                 440                 445             


Ile Gly Leu Arg Val Phe Leu Val Ile Ala Asp Ser Leu Gln Gln Lys 
    450                 455                 460                 


Asp Gly Glu Pro Pro Met Pro Thr Thr Gly Val Ile Leu Pro Ser Gly 
465                 470                 475                 480 


Asn Thr Leu Arg Val Lys Lys Ile Phe Leu Asn Lys Thr Leu Thr Asp 
                485                 490                 495     


Glu Glu Ala Lys Val Ile Gly Met Ser Val Tyr Tyr Pro Gln Val Arg 
            500                 505                 510         


Lys Ala Leu Asp Ser Ile Leu Arg His Leu Asp Lys Glu Val Gly Arg 
        515                 520                 525             


Pro Met Cys Met Thr Ser Val Gln Met Ser Asn Lys Glu Pro Glu Asp 
    530                 535                 540                 


Met Ile Thr Gly Glu Arg Lys Pro Lys Ile Asp Leu Phe Arg Thr Cys 
545                 550                 555                 560 


Ile Ala Ala Ile Pro Arg Leu Ile Pro Asp Gly Met Ser Arg Thr Asp 
                565                 570                 575     


Leu Ile Glu Leu Leu Ala Arg Leu Thr Ile His Met Asp Glu Glu Leu 
            580                 585                 590         


Arg Ala Leu Ala Phe Asn Thr Leu Gln Ala Leu Met Leu Asp Phe Pro 
        595                 600                 605             


Asp Trp Arg Glu Asp Val Leu Ser Gly Phe Val Tyr Phe Ile Val Arg 
    610                 615                 620                 


Glu Val Thr Asp Val His Pro Thr Leu Leu Asp Asn Ala Val Lys Met 
625                 630                 635                 640 


Leu Val Gln Leu Ile Asn Gln Trp Lys Gln Ala Ala Gln Met His Asn 
                645                 650                 655     


Lys Asn Gln Asp Thr Gln His Gly Val Ala Asn Gly Ala Ser His Pro 
            660                 665                 670         


Pro Pro Leu Glu Arg Ser Pro Tyr Ser Asn Val Phe His Val Val Glu 
        675                 680                 685             


Gly Phe Ala Leu Val Ile Leu Cys Ser Ser Arg Pro Ala Thr Arg Arg 
    690                 695                 700                 


Leu Ala Val Ser Val Leu Arg Glu Ile Arg Ala Leu Phe Ala Leu Leu 
705                 710                 715                 720 


Glu Ile Pro Lys Gly Asp Asp Glu Leu Ala Ile Asp Val Met Asp Arg 
                725                 730                 735     


Leu Ser Pro Ser Ile Leu Glu Ser Phe Ile His Leu Thr Gly Ala Asp 
            740                 745                 750         


Gln Thr Thr Leu Leu Tyr Cys Pro Ser Ser Ile Asp Leu Gln Thr Leu 
        755                 760                 765             


Ala Glu Trp Asn Ser Ser Pro Ile Ser His Gln Phe Asp Val Ile Ser 
    770                 775                 780                 


Pro Ser His Ile Trp Ile Phe Ala His Val Thr Gln Gly Gln Asp Pro 
785                 790                 795                 800 


Trp Ile Ile Ser Leu Ser Ser Phe Leu Lys Gln Glu Asn Leu Pro Lys 
                805                 810                 815     


His Cys Ser Thr Ala Val Ser Tyr Ala Trp Met Phe Ala Tyr Thr Arg 
            820                 825                 830         


Leu Gln Leu Leu Ser Pro Gln Val Asp Ile Asn Ser Pro Ile Asn Ala 
        835                 840                 845             


Lys Lys Val Asn Thr Thr Thr Ser Ser Asp Ser Tyr Ile Gly Leu Trp 
    850                 855                 860                 


Arg Asn Tyr Leu Ile Leu Cys Cys Ser Ala Ala Thr Ser Ser Ser Ser 
865                 870                 875                 880 


Thr Ser Ala Gly Ser Val Arg Cys Ser Pro Pro Glu Thr Leu Ala Ser 
                885                 890                 895     


Thr Pro Asp Ser Gly Tyr Ser Ile Asp Ser Lys Ile Ile Gly Ile Pro 
            900                 905                 910         


Ser Pro Ser Ser Leu Phe Lys His Ile Val Pro Met Met Arg Ser Glu 
        915                 920                 925             


Ser Met Glu Ile Thr Glu Ser Leu Val Leu Gly Leu Gly Arg Thr Asn 
    930                 935                 940                 


Pro Gly Ala Phe Arg Glu Leu Ile Glu Glu Leu His Pro Ile Ile Lys 
945                 950                 955                 960 


Glu Ala Leu Glu Arg Arg Pro Glu Asn Met Lys Arg Arg Arg Arg Arg 
                965                 970                 975     


Asp Ile Leu Arg Val Gln Leu Val Arg Ile Phe Glu Leu Leu Ala Asp 
            980                 985                 990         


Ala Gly Val Ile Ser His Ser Ala  Ser Gly Gly Leu Asp  Asn Glu Thr 
        995                 1000                 1005             


His Phe  Leu Asn Asn Thr Leu  Leu Glu Tyr Val Asp  Leu Thr Arg 
    1010                 1015                 1020             


Gln Leu  Leu Glu Ala Glu Asn  Glu Lys Asp Ser Asp  Thr Leu Lys 
    1025                 1030                 1035             


Asp Ile  Arg Cys His Phe Ser  Ala Leu Val Ala Asn  Ile Ile Gln 
    1040                 1045                 1050             


Asn Val  Pro Val His Gln Arg  Arg Ser Ile Phe Pro  Gln Gln Ser 
    1055                 1060                 1065             


Leu Arg  His Ser Leu Phe Met  Leu Phe Ser His Trp  Ala Gly Pro 
    1070                 1075                 1080             


Phe Ser  Ile Met Phe Thr Pro  Leu Asp Arg Tyr Ser  Asp Arg Asn 
    1085                 1090                 1095             


Met Gln  Ile Asn Arg His Gln  Tyr Cys Ala Leu Lys  Ala Met Ser 
    1100                 1105                 1110             


Ala Val  Leu Cys Cys Gly Pro  Val Ala Asp Asn Val  Gly Leu Ser 
    1115                 1120                 1125             


Ser Asp  Gly Tyr Leu Tyr Lys  Trp Leu Asp Asn Ile  Leu Asp Ser 
    1130                 1135                 1140             


Leu Asp  Lys Lys Val His Gln  Leu Gly Cys Glu Ala  Val Thr Leu 
    1145                 1150                 1155             


Leu Leu  Glu Leu Asn Pro Asp  Gln Ser Asn Leu Met  Tyr Trp Ala 
    1160                 1165                 1170             


Val Asp  Arg Cys Tyr Thr Gly  Ser Gly Arg Val Ala  Ala Gly Cys 
    1175                 1180                 1185             


Phe Lys  Ala Ile Ala Asn Val  Phe Gln Asn Arg Asp  Tyr Gln Cys 
    1190                 1195                 1200             


Asp Thr  Val Met Leu Leu Asn  Leu Ile Leu Phe Lys  Ala Ala Asp 
    1205                 1210                 1215             


Ser Ser  Arg Ser Ile Tyr Glu  Val Ala Met Gln Leu  Leu Gln Ile 
    1220                 1225                 1230             


Leu Glu  Pro Lys Met Phe Arg  Tyr Ala His Lys Leu  Glu Val Gln 
    1235                 1240                 1245             


Arg Thr  Asp Gly Val Leu Ser  Gln Leu Ser Pro Leu  Pro His Leu 
    1250                 1255                 1260             


Tyr Ser  Val Ser Tyr Tyr Gln  Leu Ser Glu Glu Leu  Ala Arg Ala 
    1265                 1270                 1275             


Tyr Pro  Glu Leu Thr Leu Ala  Ile Phe Ser Glu Ile  Ser Gln Arg 
    1280                 1285                 1290             


Ile Gln  Thr Ala His Pro Ala  Gly Arg Gln Val Met  Leu His Tyr 
    1295                 1300                 1305             


Leu Leu  Pro Trp Met Asn Asn  Ile Glu Leu Val Asp  Leu Lys Pro 
    1310                 1315                 1320             


Leu Pro  Thr Ala Arg Arg His  Asp Glu Asp Glu Asp  Asp Ser Leu 
    1325                 1330                 1335             


Lys Asp  Arg Glu Leu Met Val  Thr Ser Arg Arg Trp  Leu Arg Gly 
    1340                 1345                 1350             


Glu Gly  Trp Gly Ser Pro Gln  Ala Thr Ala Met Val  Leu Asn Asn 
    1355                 1360                 1365             


Leu Met  Tyr Met Thr Ala Lys  Tyr Gly Asp Glu Leu  Ala Trp Ser 
    1370                 1375                 1380             


Glu Val  Glu Asn Val Trp Thr  Thr Leu Ala Asp Gly  Trp Pro Lys 
    1385                 1390                 1395             


Asn Leu  Lys Ile Ile Leu His  Phe Leu Ile Ser Ile  Cys Gly Val 
    1400                 1405                 1410             


Asn Ser  Glu Pro Ser Leu Leu  Pro Tyr Val Lys Lys  Val Ile Val 
    1415                 1420                 1425             


Tyr Leu  Gly Arg Asp Lys Thr  Met Gln Leu Leu Glu  Glu Leu Val 
    1430                 1435                 1440             


Ser Glu  Leu Gln Leu Thr Asp  Pro Val Ser Ser Gly  Val Thr His 
    1445                 1450                 1455             


Met Asp  Asn Pro Pro Tyr Tyr  Arg Ile Thr Ser Ser  Tyr Lys Ile 
    1460                 1465                 1470             


Pro Ser  Val Thr Ser Gly Thr  Thr Ser Ser Ser Asn  Thr Met Val 
    1475                 1480                 1485             


Ala Pro  Thr Asp Gly Asn Pro  Asp Asn Lys Pro Ile  Lys Glu Asn 
    1490                 1495                 1500             


Ile Glu  Glu Ser Tyr Val His  Leu Asp Ile Tyr Ser  Gly Leu Asn 
    1505                 1510                 1515             


Ser His  Leu Asn Arg Gln His  His Arg Leu Glu Ser  Arg Tyr Ser 
    1520                 1525                 1530             


Ser Ser  Ser Gly Gly Ser Tyr  Glu Glu Glu Lys Ser  Asp Ser Met 
    1535                 1540                 1545             


Pro Leu  Tyr Ser Asn Trp Arg  Leu Lys Val Met Glu  His Asn Gln 
    1550                 1555                 1560             


Gly Glu  Pro Leu Pro Phe Pro  Pro Ala Gly Gly Cys  Trp Ser Pro 
    1565                 1570                 1575             


Leu Val  Asp Tyr Val Pro Glu  Thr Ser Ser Pro Gly  Leu Pro Leu 
    1580                 1585                 1590             


His Arg  Cys Asn Ile Ala Val  Ile Leu Leu Thr Asp  Leu Ile Ile 
    1595                 1600                 1605             


Asp His  Ser Val Lys Val Glu  Trp Gly Ser Tyr Leu  His Leu Leu 
    1610                 1615                 1620             


Leu His  Ala Ile Phe Ile Gly  Phe Asp His Cys His  Pro Glu Val 
    1625                 1630                 1635             


Tyr Glu  His Cys Lys Arg Leu  Leu Leu His Leu Leu  Ile Val Met 
    1640                 1645                 1650             


Gly Pro  Asn Ser Asn Ile Arg  Thr Val Ala Ser Val  Leu Leu Arg 
    1655                 1660                 1665             


Asn Lys  Glu Phe Asn Glu Pro  Arg Val Leu Thr Val  Lys Gln Val 
    1670                 1675                 1680             


Ala His  Leu Asp Tyr Asn Phe  Thr Ala Gly Ile Asn  Asp Phe Ile 
    1685                 1690                 1695             


Pro Asp  Tyr Gln Pro Ser Pro  Met Thr Asp Ser Gly  Leu Ser Ser 
    1700                 1705                 1710             


Ser Ser  Thr Ser Ser Ser Ile  Ser Leu Gly Asn Asn  Ser Ala Ala 
    1715                 1720                 1725             


Ile Ser  His Leu His Thr Thr  Ile Leu Asn Glu Val  Asp Ile Ser 
    1730                 1735                 1740             


Val Glu  Gln Asp Gly Lys Val  Lys Thr Leu Met Glu  Phe Ile Thr 
    1745                 1750                 1755             


Ser Arg  Lys Arg Gly Pro Leu  Trp Asn His Glu Asp  Val Ser Ala 
    1760                 1765                 1770             


Lys Asn  Pro Ser Ile Lys Ser  Ala Glu Gln Leu Thr  Thr Phe Leu 
    1775                 1780                 1785             


Lys His  Val Val Ser Val Phe  Lys Gln Ser Ser Ser  Glu Gly Ile 
    1790                 1795                 1800             


His Leu  Glu His His Leu Ser  Glu Val Ala Leu Gln  Thr Ala Leu 
    1805                 1810                 1815             


Ser Cys  Ser Ser Arg His Tyr  Ala Gly Arg Ser Phe  Gln Ile Phe 
    1820                 1825                 1830             


Arg Ala  Leu Lys Gln Pro Leu  Thr Ala Thr Thr Leu  Ser Asp Val 
    1835                 1840                 1845             


Leu Ser  Arg Leu Val Glu Thr  Val Gly Asp Pro Gly  Glu Asp Ala 
    1850                 1855                 1860             


Gln Gly  Phe Val Ile Glu Leu  Leu Leu Thr Leu Glu  Ser Ala Ile 
    1865                 1870                 1875             


Asp Thr  Leu Ala Glu Thr Met  Lys His Tyr Asp Leu  Leu Ser Ala 
    1880                 1885                 1890             


Leu Ser  Gln Thr Ser Tyr His  Asp Pro Ile Met Gly  Asn Lys Tyr 
    1895                 1900                 1905             


Ala Ala  Asn Arg Lys Ser Thr  Gly Gln Leu Asn Leu  Ser Thr Ser 
    1910                 1915                 1920             


Pro Ile  Asn Ser Ser Ser Tyr  Leu Gly Tyr Asn Ser  Asn Ala Arg 
    1925                 1930                 1935             


Ser Asn  Ser Leu Arg Leu Ser  Leu Ile Gly Asp Arg  Arg Gly Asp 
    1940                 1945                 1950             


Arg Arg  Arg Ser Asn Thr Leu  Asp Ile Met Asp Gly  Arg Ile Asn 
    1955                 1960                 1965             


His Ser  Ser Ser Leu Ala Arg  Thr Arg Ser Leu Ser  Ser Leu Arg 
    1970                 1975                 1980             


Glu Lys  Gly Met Tyr Asp Val  Gln Ser Thr Thr Glu  Pro Thr Asn 
    1985                 1990                 1995             


Leu Met  Ala Thr Ile Phe Trp  Ile Ala Ala Ser Leu  Leu Glu Ser 
    2000                 2005                 2010             


Asp Tyr  Glu Tyr Glu Tyr Leu  Leu Ala Leu Arg Leu  Leu Asn Lys 
    2015                 2020                 2025             


Leu Leu  Ile His Leu Pro Leu  Asp Lys Ser Glu Ser  Arg Glu Lys 
    2030                 2035                 2040             


Ile Glu  Asn Val Gln Ser Lys  Leu Lys Trp Thr Asn  Phe Pro Gly 
    2045                 2050                 2055             


Leu Gln  Gln Leu Phe Leu Lys  Gly Phe Thr Ser Ala  Ser Thr Gln 
    2060                 2065                 2070             


Glu Met  Thr Val His Leu Leu  Ser Lys Leu Ile Ser  Val Ser Lys 
    2075                 2080                 2085             


His Thr  Leu Val Asp Pro Ser  Gln Leu Ser Gly Phe  Pro Leu Asn 
    2090                 2095                 2100             


Ile Leu  Cys Leu Leu Pro His  Leu Ile Gln His Phe  Asp Ser Pro 
    2105                 2110                 2115             


Thr Gln  Phe Cys Lys Glu Thr  Ala Ser Arg Ile Ala  Lys Val Cys 
    2120                 2125                 2130             


Ala Glu  Glu Lys Cys Pro Thr  Leu Val Asn Leu Ala  His Met Met 
    2135                 2140                 2145             


Ser Leu  Tyr Ser Thr His Thr  Tyr Ser Arg Asp Cys  Ser Asn Trp 
    2150                 2155                 2160             


Ile Asn  Val Val Cys Arg Tyr  Leu His Asp Ser Phe  Ser Asp Thr 
    2165                 2170                 2175             


Thr Phe  Asn Leu Val Thr Tyr  Leu Ala Glu Leu Leu  Glu Lys Gly 
    2180                 2185                 2190             


Leu Ser  Ser Met Gln Gln Ser  Leu Leu Gln Ile Ile  Tyr Ser Leu 
    2195                 2200                 2205             


Leu Ser  His Ile Asp Leu Ser  Ala Ala Pro Ala Lys  Gln Phe Asn 
    2210                 2215                 2220             


Leu Glu  Ile Ile Lys Ile Ile  Gly Lys Tyr Val Gln  Ser Pro Tyr 
    2225                 2230                 2235             


Trp Lys  Glu Ala Leu Asn Ile  Leu Lys Leu Val Val  Ser Arg Ser 
    2240                 2245                 2250             


Ala Ser  Leu Val Val Pro Ser  Asp Ile Pro Lys Thr  Tyr Gly Gly 
    2255                 2260                 2265             


Asp Thr  Gly Ser Pro Glu Ile  Ser Phe Thr Lys Ile  Phe Asn Asn 
    2270                 2275                 2280             


Val Ser  Lys Glu Leu Pro Gly  Lys Thr Leu Asp Phe  His Phe Asp 
    2285                 2290                 2295             


Ile Ser  Glu Thr Pro Ile Ile  Gly Asn Lys Tyr Gly  Asp Gln His 
    2300                 2305                 2310             


Ser Ala  Ala Gly Arg Asn Gly  Lys Pro Lys Val Ile  Ala Val Thr 
    2315                 2320                 2325             


Arg Ser  Thr Ser Ser Thr Ser  Ser Gly Ser Asn Ser  Asn Ala Leu 
    2330                 2335                 2340             


Val Pro  Val Ser Trp Lys Arg  Pro Gln Leu Ser Gln  Arg Arg Thr 
    2345                 2350                 2355             


Arg Glu  Lys Leu Met Asn Val  Leu Ser Leu Cys Gly  Pro Glu Ser 
    2360                 2365                 2370             


Gly Leu  Pro Lys Asn Pro Ser  Val Val Phe Ser Ser  Asn Glu Asp 
    2375                 2380                 2385             


Leu Glu  Val Gly Asp Gln Gln  Thr Ser Leu Ile Ser  Thr Thr Glu 
    2390                 2395                 2400             


Asp Ile  Asn Gln Glu Glu Glu  Val Ala Val Glu Asp  Asn Ser Ser 
    2405                 2410                 2415             


Glu Gln  Gln Phe Gly Val Phe  Lys Asp Phe Asp Phe  Leu Asp Val 
    2420                 2425                 2430             


Glu Leu  Glu Asp Ala Glu Gly  Glu Ser Met Asp Asn  Phe Asn Trp 
    2435                 2440                 2445             


Gly Val  Arg Arg Arg Ser Leu  Asp Ser Ile Asp Lys  Gly Asp Thr 
    2450                 2455                 2460             


Pro Ser  Leu Gln Glu Tyr Gln  Cys Ser Ser Ser Thr  Pro Ser Leu 
    2465                 2470                 2475             


Asn Leu  Thr Asn Gln Glu Asp  Thr Asp Glu Ser Ser  Glu Glu Glu 
    2480                 2485                 2490             


Ala Ala  Leu Thr Ala Ser Gln  Ile Leu Ser Arg Thr  Gln Met Leu 
    2495                 2500                 2505             


Asn Ser  Asp Ser Ala Thr Asp  Glu Thr Ile Pro Asp  His Pro Asp 
    2510                 2515                 2520             


Leu Leu  Leu Gln Ser Glu Asp  Ser Thr Gly Ser Ile  Thr Thr Glu 
    2525                 2530                 2535             


Glu Val  Leu Gln Ile Arg Asp  Glu Thr Pro Thr Leu  Glu Ala Ser 
    2540                 2545                 2550             


Leu Asp  Asn Ala Asn Ser Arg  Leu Pro Glu Asp Thr  Thr Ser Val 
    2555                 2560                 2565             


Leu Lys  Glu Glu His Val Thr  Thr Phe Glu Asp Glu  Gly Ser Tyr 
    2570                 2575                 2580             


Ile Ile  Gln Glu Gln Gln Glu  Ser Leu Val Cys Gln  Gly Ile Leu 
    2585                 2590                 2595             


Asp Leu  Glu Glu Thr Glu Met  Pro Glu Pro Leu Ala  Pro Glu Ser 
    2600                 2605                 2610             


Tyr Pro  Glu Ser Val Cys Glu  Glu Asp Val Thr Leu  Ala Leu Lys 
    2615                 2620                 2625             


Glu Leu  Asp Glu Arg Cys Glu  Glu Glu Glu Ala Asp  Phe Ser Gly 
    2630                 2635                 2640             


Leu Ser  Ser Gln Asp Glu Glu  Glu Gln Asp Gly Phe  Pro Glu Val 
    2645                 2650                 2655             


Gln Thr  Ser Pro Leu Pro Ser  Pro Phe Leu Ser Ala  Ile Ile Ala 
    2660                 2665                 2670             


Ala Phe  Gln Pro Val Ala Tyr  Asp Asp Glu Glu Glu  Ala Trp Arg 
    2675                 2680                 2685             


Cys His  Val Asn Gln Met Leu  Ser Asp Thr Asp Gly  Ser Ser Ala 
    2690                 2695                 2700             


Val Phe  Thr Phe His Val Phe  Ser Arg Leu Phe Gln  Thr Ile Gln 
    2705                 2710                 2715             


Arg Lys  Phe Gly Glu Ile Thr  Asn Glu Ala Val Ser  Phe Leu Gly 
    2720                 2725                 2730             


Asp Ser  Leu Gln Arg Ile Gly  Thr Lys Phe Lys Ser  Ser Leu Glu 
    2735                 2740                 2745             


Val Met  Met Leu Cys Ser Glu  Cys Pro Thr Val Phe  Val Asp Ala 
    2750                 2755                 2760             


Glu Thr  Leu Met Ser Cys Gly  Leu Leu Glu Thr Leu  Lys Phe Gly 
    2765                 2770                 2775             


Val Leu  Glu Leu Gln Glu His  Leu Asp Thr Tyr Asn  Val Lys Arg 
    2780                 2785                 2790             


Glu Ala  Ala Glu Gln Trp Leu  Asp Asp Cys Lys Arg  Thr Phe Gly 
    2795                 2800                 2805             


Ala Lys  Glu Asp Met Tyr Arg  Ile Asn Thr Asp Ala  Gln Gln Met 
    2810                 2815                 2820             


Glu Ile  Leu Ala Glu Leu Glu  Leu Cys Arg Arg Leu  Tyr Lys Leu 
    2825                 2830                 2835             


His Phe  Gln Leu Leu Leu Leu  Phe Gln Ala Tyr Cys  Lys Leu Ile 
    2840                 2845                 2850             


Asn Gln  Val Asn Thr Ile Lys  Asn Glu Ala Glu Val  Ile Asn Met 
    2855                 2860                 2865             


Ser Glu  Glu Leu Ala Gln Leu  Glu Ser Ile Leu Lys  Glu Ala Glu 
    2870                 2875                 2880             


Ser Ala  Ser Glu Asn Glu Glu  Ile Asp Ile Ser Lys  Ala Ala Gln 
    2885                 2890                 2895             


Thr Thr  Ile Glu Thr Ala Ile  His Ser Leu Ile Glu  Thr Leu Lys 
    2900                 2905                 2910             


Asn Lys  Glu Phe Ile Ser Ala  Val Ala Gln Val Lys  Ala Phe Arg 
    2915                 2920                 2925             


Ser Leu  Trp Pro Ser Asp Ile  Phe Gly Ser Cys Glu  Asp Asp Pro 
    2930                 2935                 2940             


Val Gln  Thr Leu Leu His Ile  Tyr Phe His His Gln  Thr Leu Gly 
    2945                 2950                 2955             


Gln Thr  Gly Ser Phe Ala Val  Ile Gly Ser Asn Leu  Asp Met Ser 
    2960                 2965                 2970             


Glu Ala  Asn Tyr Lys Leu Met  Glu Leu Asn Leu Glu  Ile Arg Glu 
    2975                 2980                 2985             


Ser Leu  Arg Met Val Gln Ser  Tyr Gln Leu Leu Ala  Gln Ala Lys 
    2990                 2995                 3000             


Pro Met  Gly Asn Met Val Ser  Thr Gly Phe 
    3005                 3010             


<210>  4195
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FRZB__Homo_sapiens__NP_001454

<400>  4195

Met Val Cys Gly Ser Pro Gly Gly Met Leu Leu Leu Arg Ala Gly Leu 
1               5                   10                  15      


Leu Ala Leu Ala Ala Leu Cys Leu Leu Arg Val Pro Gly Ala Arg Ala 
            20                  25                  30          


Ala Ala Cys Glu Pro Val Arg Ile Pro Leu Cys Lys Ser Leu Pro Trp 
        35                  40                  45              


Asn Met Thr Lys Met Pro Asn His Leu His His Ser Thr Gln Ala Asn 
    50                  55                  60                  


Ala Ile Leu Ala Ile Glu Gln Phe Glu Gly Leu Leu Gly Thr His Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Leu Phe Phe Leu Cys Ala Met Tyr Ala Pro Ile Cys 
                85                  90                  95      


Thr Ile Asp Phe Gln His Glu Pro Ile Lys Pro Cys Lys Ser Val Cys 
            100                 105                 110         


Glu Arg Ala Arg Gln Gly Cys Glu Pro Ile Leu Ile Lys Tyr Arg His 
        115                 120                 125             


Ser Trp Pro Glu Asn Leu Ala Cys Glu Glu Leu Pro Val Tyr Asp Arg 
    130                 135                 140                 


Gly Val Cys Ile Ser Pro Glu Ala Ile Val Thr Ala Asp Gly Ala Asp 
145                 150                 155                 160 


Phe Pro Met Asp Ser Ser Asn Gly Asn Cys Arg Gly Ala Ser Ser Glu 
                165                 170                 175     


Arg Cys Lys Cys Lys Pro Ile Arg Ala Thr Gln Lys Thr Tyr Phe Arg 
            180                 185                 190         


Asn Asn Tyr Asn Tyr Val Ile Arg Ala Lys Val Lys Glu Ile Lys Thr 
        195                 200                 205             


Lys Cys His Asp Val Thr Ala Val Val Glu Val Lys Glu Ile Leu Lys 
    210                 215                 220                 


Ser Ser Leu Val Asn Ile Pro Arg Asp Thr Val Asn Leu Tyr Thr Ser 
225                 230                 235                 240 


Ser Gly Cys Leu Cys Pro Pro Leu Asn Val Asn Glu Glu Tyr Ile Ile 
                245                 250                 255     


Met Gly Tyr Glu Asp Glu Glu Arg Ser Arg Leu Leu Leu Val Glu Gly 
            260                 265                 270         


Ser Ile Ala Glu Lys Trp Lys Asp Arg Leu Gly Lys Lys Val Lys Arg 
        275                 280                 285             


Trp Asp Met Lys Leu Arg His Leu Gly Leu Ser Lys Ser Asp Ser Ser 
    290                 295                 300                 


Asn Ser Asp Ser Thr Gln Ser Gln Lys Ser Gly Arg Asn Ser Asn Pro 
305                 310                 315                 320 


Arg Gln Ala Arg Asn 
                325 


<210>  4196
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSBP__Homo_sapiens__NP_001243070

<400>  4196

Met Val Gly Lys Ala Arg Ser Ser Asn Phe Thr Leu Ser Glu Lys Leu 
1               5                   10                  15      


Asp Leu Leu Lys Leu Val Lys Pro Tyr Val Lys Ile Leu Glu Glu His 
            20                  25                  30          


Thr Asn Lys His Ser Val Ile Val Glu Lys Asn Arg Cys Trp Asp Ile 
        35                  40                  45              


Ile Ala Val Asn Tyr Asn Ala Ile Gly Val Asp Arg Pro Pro Arg Thr 
    50                  55                  60                  


Ala Gln Gly Leu Arg Thr Leu Tyr Lys Arg Leu Lys Glu Tyr Ala Lys 
65                  70                  75                  80  


Gln Glu Leu Leu Gln Gln Lys Glu Thr Gln Ser Asp Phe Lys Ser Asn 
                85                  90                  95      


Ile Ser Glu Pro Thr Lys Lys Val Met Glu Met Ile Pro Gln Ile Ser 
            100                 105                 110         


Ser Phe Cys Leu Val Arg Asp Arg Asn His Ile Gln Ser Ala Asn Leu 
        115                 120                 125             


Asp Glu Glu Ala Gln Ala Gly Thr Ser Ser Leu Gln Val Met Leu Asp 
    130                 135                 140                 


His His Pro Val Ala Ile Thr Val Glu Val Lys Gln Glu Glu Asp Ile 
145                 150                 155                 160 


Lys Pro Pro Pro Pro Leu Val Leu Asn Ser Gln Gln Ser Asp Thr Leu 
                165                 170                 175     


Glu Gln Arg Glu Glu His Glu Leu Val His Val Met Glu Arg Ser Leu 
            180                 185                 190         


Ser Pro Ser Leu Ser Ser Val Asp Met Arg Met Thr Ser Ser Pro Ser 
        195                 200                 205             


Ser Ile Pro Arg Arg Asp Asp Phe Phe Arg His Glu Ser Gly Glu His 
    210                 215                 220                 


Phe Arg Ser Leu Leu Gly Tyr Asp Pro Gln Ile Leu Gln Met Leu Lys 
225                 230                 235                 240 


Glu Glu His Gln Ile Ile Leu Glu Asn Gln Lys Asn Phe Gly Leu Tyr 
                245                 250                 255     


Val Gln Glu Lys Arg Asp Gly Leu Lys Arg Arg Gln Gln Leu Glu Glu 
            260                 265                 270         


Glu Leu Leu Arg Ala Lys Ile Glu Val Glu Lys Leu Lys Ala Ile Arg 
        275                 280                 285             


Leu Arg His Asp Leu Pro Glu Tyr Asn Ser Leu 
    290                 295                 


<210>  4197
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSCB__Homo_sapiens__NP_115511

<400>  4197

Met Val Gly Lys Ser Gln Gln Thr Asp Val Ile Glu Lys Lys Lys His 
1               5                   10                  15      


Met Ala Ile Pro Lys Ser Ser Ser Pro Lys Ala Thr His Arg Ile Gly 
            20                  25                  30          


Asn Thr Ser Gly Ser Lys Gly Ser Tyr Ser Ala Lys Ala Tyr Glu Ser 
        35                  40                  45              


Ile Arg Val Ser Ser Glu Leu Gln Gln Thr Trp Thr Lys Arg Lys His 
    50                  55                  60                  


Gly Gln Glu Met Thr Ser Lys Ser Leu Gln Thr Asp Thr Ile Val Glu 
65                  70                  75                  80  


Glu Lys Lys Glu Val Lys Leu Val Glu Glu Thr Val Val Pro Glu Glu 
                85                  90                  95      


Lys Ser Ala Asp Val Arg Glu Ala Ala Ile Glu Leu Pro Glu Ser Val 
            100                 105                 110         


Gln Asp Val Glu Ile Pro Pro Asn Ile Pro Ser Val Gln Leu Lys Met 
        115                 120                 125             


Asp Arg Ser Gln Gln Thr Ser Arg Thr Gly Tyr Trp Thr Met Met Asn 
    130                 135                 140                 


Ile Pro Pro Val Glu Lys Val Asp Lys Glu Gln Gln Thr Tyr Phe Ser 
145                 150                 155                 160 


Glu Ser Glu Ile Val Val Ile Ser Arg Pro Asp Ser Ser Ser Thr Lys 
                165                 170                 175     


Ser Lys Glu Asp Ala Leu Lys His Lys Ser Ser Gly Lys Ile Phe Ala 
            180                 185                 190         


Ser Glu His Pro Glu Phe Gln Pro Ala Thr Asn Ser Asn Glu Glu Ile 
        195                 200                 205             


Gly Gln Lys Asn Ile Ser Arg Thr Ser Phe Thr Gln Glu Thr Lys Lys 
    210                 215                 220                 


Gly Pro Pro Val Leu Leu Glu Asp Glu Leu Arg Glu Glu Val Thr Val 
225                 230                 235                 240 


Pro Val Val Gln Glu Gly Ser Ala Val Lys Lys Val Ala Ser Ala Glu 
                245                 250                 255     


Ile Glu Pro Pro Ser Thr Glu Lys Phe Pro Ala Lys Ile Gln Pro Pro 
            260                 265                 270         


Leu Val Glu Glu Ala Thr Ala Lys Ala Glu Pro Arg Pro Ala Glu Glu 
        275                 280                 285             


Thr His Val Gln Val Gln Pro Ser Thr Glu Glu Thr Pro Asp Ala Glu 
    290                 295                 300                 


Ala Ala Thr Ala Val Ala Glu Asn Ser Val Lys Val Gln Pro Pro Pro 
305                 310                 315                 320 


Ala Glu Glu Ala Pro Leu Val Glu Phe Pro Ala Glu Ile Gln Pro Pro 
                325                 330                 335     


Ser Ala Glu Glu Ser Pro Ser Val Glu Leu Leu Ala Glu Ile Leu Pro 
            340                 345                 350         


Pro Ser Ala Glu Glu Ser Pro Ser Glu Glu Pro Pro Ala Glu Ile Leu 
        355                 360                 365             


Pro Pro Pro Ala Glu Lys Ser Pro Ser Val Glu Leu Leu Gly Glu Ile 
    370                 375                 380                 


Arg Ser Pro Ser Ala Gln Lys Ala Pro Ile Glu Val Gln Pro Leu Pro 
385                 390                 395                 400 


Ala Glu Gly Ala Leu Glu Glu Ala Pro Ala Lys Val Glu Pro Pro Thr 
                405                 410                 415     


Val Glu Glu Thr Leu Ala Asp Val Gln Pro Leu Leu Pro Glu Glu Ala 
            420                 425                 430         


Pro Arg Glu Glu Ala Arg Glu Leu Gln Leu Ser Thr Ala Met Glu Thr 
        435                 440                 445             


Pro Ala Glu Glu Ala Pro Thr Glu Phe Gln Ser Pro Leu Pro Lys Glu 
    450                 455                 460                 


Thr Thr Ala Glu Glu Ala Ser Ala Glu Ile Gln Leu Leu Ala Ala Thr 
465                 470                 475                 480 


Glu Pro Pro Ala Asp Glu Thr Pro Ala Glu Ala Arg Ser Pro Leu Ser 
                485                 490                 495     


Glu Glu Thr Ser Ala Glu Glu Ala His Ala Glu Val Gln Ser Pro Leu 
            500                 505                 510         


Ala Glu Glu Thr Thr Ala Glu Glu Ala Ser Ala Glu Ile Gln Leu Leu 
        515                 520                 525             


Ala Ala Ile Glu Ala Pro Ala Asp Glu Thr Pro Ala Glu Ala Gln Ser 
    530                 535                 540                 


Pro Leu Ser Glu Glu Thr Ser Ala Glu Glu Ala Pro Ala Glu Val Gln 
545                 550                 555                 560 


Ser Pro Ser Ala Lys Gly Val Ser Ile Glu Glu Ala Pro Leu Glu Leu 
                565                 570                 575     


Gln Pro Pro Ser Gly Glu Glu Thr Thr Ala Glu Glu Ala Ser Ala Ala 
            580                 585                 590         


Ile Gln Leu Leu Ala Ala Thr Glu Ala Ser Ala Glu Glu Ala Pro Ala 
        595                 600                 605             


Glu Val Gln Pro Pro Pro Ala Glu Glu Ala Pro Ala Glu Val Gln Pro 
    610                 615                 620                 


Pro Pro Ala Glu Glu Ala Pro Ala Glu Val Gln Pro Pro Pro Ala Glu 
625                 630                 635                 640 


Glu Ala Pro Ala Glu Val Gln Pro Pro Pro Ala Glu Glu Ala Pro Ala 
                645                 650                 655     


Glu Val Gln Pro Pro Pro Ala Glu Glu Ala Pro Ala Glu Val Gln Pro 
            660                 665                 670         


Pro Pro Ala Glu Glu Ala Pro Ala Glu Val Gln Ser Leu Pro Ala Glu 
        675                 680                 685             


Glu Thr Pro Ile Glu Glu Thr Leu Ala Ala Val His Ser Pro Pro Ala 
    690                 695                 700                 


Asp Asp Val Pro Ala Glu Glu Ala Ser Val Asp Lys His Ser Pro Pro 
705                 710                 715                 720 


Ala Asp Leu Leu Leu Thr Glu Glu Phe Pro Ile Gly Glu Ala Ser Ala 
                725                 730                 735     


Glu Val Ser Pro Pro Pro Ser Glu Gln Thr Pro Glu Asp Glu Ala Leu 
            740                 745                 750         


Val Glu Asn Val Ser Thr Glu Phe Gln Ser Pro Gln Val Ala Gly Ile 
        755                 760                 765             


Pro Ala Val Lys Leu Gly Ser Val Val Leu Glu Gly Glu Ala Lys Phe 
    770                 775                 780                 


Glu Glu Val Ser Lys Ile Asn Ser Val Leu Lys Asp Leu Ser Asn Thr 
785                 790                 795                 800 


Asn Asp Gly Gln Ala Pro Thr Leu Glu Ile Glu Ser Val Phe His Ile 
                805                 810                 815     


Glu Leu Lys Gln Arg Pro Pro Glu Leu 
            820                 825 


<210>  4198
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSCN1__Homo_sapiens__NP_003079

<400>  4198

Met Thr Ala Asn Gly Thr Ala Glu Ala Val Gln Ile Gln Phe Gly Leu 
1               5                   10                  15      


Ile Asn Cys Gly Asn Lys Tyr Leu Thr Ala Glu Ala Phe Gly Phe Lys 
            20                  25                  30          


Val Asn Ala Ser Ala Ser Ser Leu Lys Lys Lys Gln Ile Trp Thr Leu 
        35                  40                  45              


Glu Gln Pro Pro Asp Glu Ala Gly Ser Ala Ala Val Cys Leu Arg Ser 
    50                  55                  60                  


His Leu Gly Arg Tyr Leu Ala Ala Asp Lys Asp Gly Asn Val Thr Cys 
65                  70                  75                  80  


Glu Arg Glu Val Pro Gly Pro Asp Cys Arg Phe Leu Ile Val Ala His 
                85                  90                  95      


Asp Asp Gly Arg Trp Ser Leu Gln Ser Glu Ala His Arg Arg Tyr Phe 
            100                 105                 110         


Gly Gly Thr Glu Asp Arg Leu Ser Cys Phe Ala Gln Thr Val Ser Pro 
        115                 120                 125             


Ala Glu Lys Trp Ser Val His Ile Ala Met His Pro Gln Val Asn Ile 
    130                 135                 140                 


Tyr Ser Val Thr Arg Lys Arg Tyr Ala His Leu Ser Ala Arg Pro Ala 
145                 150                 155                 160 


Asp Glu Ile Ala Val Asp Arg Asp Val Pro Trp Gly Val Asp Ser Leu 
                165                 170                 175     


Ile Thr Leu Ala Phe Gln Asp Gln Arg Tyr Ser Val Gln Thr Ala Asp 
            180                 185                 190         


His Arg Phe Leu Arg His Asp Gly Arg Leu Val Ala Arg Pro Glu Pro 
        195                 200                 205             


Ala Thr Gly Tyr Thr Leu Glu Phe Arg Ser Gly Lys Val Ala Phe Arg 
    210                 215                 220                 


Asp Cys Glu Gly Arg Tyr Leu Ala Pro Ser Gly Pro Ser Gly Thr Leu 
225                 230                 235                 240 


Lys Ala Gly Lys Ala Thr Lys Val Gly Lys Asp Glu Leu Phe Ala Leu 
                245                 250                 255     


Glu Gln Ser Cys Ala Gln Val Val Leu Gln Ala Ala Asn Glu Arg Asn 
            260                 265                 270         


Val Ser Thr Arg Gln Gly Met Asp Leu Ser Ala Asn Gln Asp Glu Glu 
        275                 280                 285             


Thr Asp Gln Glu Thr Phe Gln Leu Glu Ile Asp Arg Asp Thr Lys Lys 
    290                 295                 300                 


Cys Ala Phe Arg Thr His Thr Gly Lys Tyr Trp Thr Leu Thr Ala Thr 
305                 310                 315                 320 


Gly Gly Val Gln Ser Thr Ala Ser Ser Lys Asn Ala Ser Cys Tyr Phe 
                325                 330                 335     


Asp Ile Glu Trp Arg Asp Arg Arg Ile Thr Leu Arg Ala Ser Asn Gly 
            340                 345                 350         


Lys Phe Val Thr Ser Lys Lys Asn Gly Gln Leu Ala Ala Ser Val Glu 
        355                 360                 365             


Thr Ala Gly Asp Ser Glu Leu Phe Leu Met Lys Leu Ile Asn Arg Pro 
    370                 375                 380                 


Ile Ile Val Phe Arg Gly Glu His Gly Phe Ile Gly Cys Arg Lys Val 
385                 390                 395                 400 


Thr Gly Thr Leu Asp Ala Asn Arg Ser Ser Tyr Asp Val Phe Gln Leu 
                405                 410                 415     


Glu Phe Asn Asp Gly Ala Tyr Asn Ile Lys Asp Ser Thr Gly Lys Tyr 
            420                 425                 430         


Trp Thr Val Gly Ser Asp Ser Ala Val Thr Ser Ser Gly Asp Thr Pro 
        435                 440                 445             


Val Asp Phe Phe Phe Glu Phe Cys Asp Tyr Asn Lys Val Ala Ile Lys 
    450                 455                 460                 


Val Gly Gly Arg Tyr Leu Lys Gly Asp His Ala Gly Val Leu Lys Ala 
465                 470                 475                 480 


Ser Ala Glu Thr Val Asp Pro Ala Ser Leu Trp Glu Tyr 
                485                 490             


<210>  4199
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSCN2__Homo_sapiens__XP_011522894

<400>  4199

Met Pro Thr Asn Gly Leu His Gln Val Leu Lys Ile Gln Phe Gly Leu 
1               5                   10                  15      


Val Asn Asp Thr Asp Arg Tyr Leu Thr Ala Glu Ser Phe Gly Phe Lys 
            20                  25                  30          


Val Asn Ala Ser Ala Pro Ser Leu Lys Arg Lys Gln Thr Trp Val Leu 
        35                  40                  45              


Glu Pro Asp Pro Gly Gln Gly Thr Ala Val Leu Leu Arg Ser Ser His 
    50                  55                  60                  


Leu Gly Arg Tyr Leu Ser Ala Glu Glu Asp Gly Arg Val Ala Cys Glu 
65                  70                  75                  80  


Ala Glu Gln Pro Gly Arg Asp Cys Arg Phe Leu Val Leu Pro Gln Pro 
                85                  90                  95      


Asp Gly Arg Trp Val Leu Arg Ser Glu Pro His Gly Arg Phe Phe Gly 
            100                 105                 110         


Gly Thr Glu Asp Gln Leu Ser Cys Phe Ala Thr Ala Val Ser Pro Ala 
        115                 120                 125             


Glu Leu Trp Thr Val His Leu Ala Ile His Pro Gln Ala His Leu Leu 
    130                 135                 140                 


Ser Val Ser Arg Arg Arg Tyr Val His Leu Cys Pro Arg Glu Asp Glu 
145                 150                 155                 160 


Met Ala Ala Asp Gly Asp Lys Pro Trp Gly Val Asp Ala Leu Leu Thr 
                165                 170                 175     


Leu Ile Phe Arg Ser Arg Arg Tyr Cys Leu Lys Ser Cys Asp Ser Arg 
            180                 185                 190         


Tyr Leu Arg Ser Asp Gly Arg Leu Val Trp Glu Pro Glu Pro Arg Ala 
        195                 200                 205             


Cys Tyr Thr Leu Glu Phe Lys Ala Gly Lys Leu Ala Phe Lys Asp Cys 
    210                 215                 220                 


Asp Gly His Tyr Leu Ala Pro Val Gly Pro Ala Gly Thr Leu Lys Ala 
225                 230                 235                 240 


Gly Arg Asn Thr Arg Pro Gly Lys Asp Glu Leu Phe Asp Leu Glu Glu 
                245                 250                 255     


Ser His Pro Gln Val Val Leu Val Ala Ala Asn His Arg Tyr Val Ser 
            260                 265                 270         


Val Arg Gln Gly Val Asn Val Ser Ala Asn Gln Asp Asp Glu Leu Asp 
        275                 280                 285             


His Glu Thr Phe Leu Met Gln Ile Asp Gln Glu Thr Lys Lys Cys Thr 
    290                 295                 300                 


Phe Tyr Ser Ser Thr Gly Gly Tyr Trp Thr Leu Val Thr His Gly Gly 
305                 310                 315                 320 


Ile His Ala Thr Ala Thr Gln Val Ser Ala Asn Thr Met Phe Glu Met 
                325                 330                 335     


Glu Trp Arg Gly Arg Arg Val Ala Leu Lys Ala Ser Asn Gly Arg Tyr 
            340                 345                 350         


Val Cys Met Lys Lys Asn Gly Gln Leu Ala Ala Ile Ser Asp Phe Val 
        355                 360                 365             


Gly Pro Pro Pro Arg Pro Ala Trp Thr Gly Lys Val Ala Gly Gly Ala 
    370                 375                 380                 


Ala Gln Gln Thr Leu Ser Pro Pro Gly Lys Asp Glu Glu Phe Thr Leu 
385                 390                 395                 400 


Lys Leu Ile Asn Arg Pro Ile Leu Val Leu Arg Gly Leu Asp Gly Phe 
                405                 410                 415     


Val Cys His His Arg Gly Ser Asn Gln Leu Asp Thr Asn Arg Ser Val 
            420                 425                 430         


Tyr Asp Val Phe His Leu Ser Phe Ser Asp Gly Ala Tyr Arg Ile Arg 
        435                 440                 445             


Gly Arg Asp Gly Gly Phe Trp Tyr Thr Gly Ser His Gly Ser Val Cys 
    450                 455                 460                 


Ser Asp Gly Glu Arg Ala Glu Asp Phe Val Phe Glu Phe Arg Glu Arg 
465                 470                 475                 480 


Gly Arg Leu Ala Ile Arg Ala Arg Ser Gly Lys Tyr Leu Arg Gly Gly 
                485                 490                 495     


Ala Ser Gly Leu Leu Arg Ala Asp Ala Asp Ala Pro Ala Gly Thr Ala 
            500                 505                 510         


Leu Trp Glu Tyr 
        515     


<210>  4200
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSD1__Homo_sapiens__NP_077309

<400>  4200

Met Glu Glu Gln Arg Glu Ala Leu Arg Lys Ile Ile Lys Thr Leu Ala 
1               5                   10                  15      


Val Lys Asn Glu Glu Ile Gln Ser Phe Ile Tyr Ser Leu Lys Gln Met 
            20                  25                  30          


Leu Leu Asn Val Glu Ala Asn Ser Ala Lys Val Gln Glu Asp Leu Glu 
        35                  40                  45              


Ala Glu Phe Gln Ser Leu Phe Ser Leu Leu Glu Glu Leu Lys Glu Gly 
    50                  55                  60                  


Met Leu Met Lys Ile Lys Gln Asp Arg Ala Ser Arg Thr Tyr Glu Leu 
65                  70                  75                  80  


Gln Asn Gln Leu Ala Ala Cys Thr Arg Ala Leu Glu Ser Ser Glu Glu 
                85                  90                  95      


Leu Leu Glu Thr Ala Asn Gln Thr Leu Gln Ala Met Asp Ser Glu Asp 
            100                 105                 110         


Phe Pro Gln Ala Ala Lys Gln Ile Lys Asp Gly Val Thr Met Ala Pro 
        115                 120                 125             


Ala Phe Arg Leu Ser Leu Lys Ala Lys Val Ser Asp Asn Met Ser His 
    130                 135                 140                 


Leu Met Val Asp Phe Ala Gln Glu Arg Gln Met Leu Gln Ala Leu Lys 
145                 150                 155                 160 


Phe Leu Pro Val Pro Ser Ala Pro Val Ile Asp Leu Ala Glu Ser Leu 
                165                 170                 175     


Val Ala Asp Asn Cys Val Thr Leu Val Trp Arg Met Pro Asp Glu Asp 
            180                 185                 190         


Ser Lys Ile Asp His Tyr Val Leu Glu Tyr Arg Arg Thr Asn Phe Glu 
        195                 200                 205             


Gly Pro Pro Arg Leu Lys Glu Asp Gln Pro Trp Met Val Ile Glu Gly 
    210                 215                 220                 


Ile Arg Gln Thr Glu Tyr Thr Leu Thr Gly Leu Lys Phe Asp Met Lys 
225                 230                 235                 240 


Tyr Met Asn Phe Arg Val Lys Ala Cys Asn Lys Ala Val Ala Gly Glu 
                245                 250                 255     


Phe Ser Glu Pro Val Thr Leu Glu Thr Pro Ala Phe Met Phe Arg Leu 
            260                 265                 270         


Asp Ala Ser Thr Ser His Gln Asn Leu Arg Val Asp Asp Leu Ser Val 
        275                 280                 285             


Glu Trp Asp Ala Met Gly Gly Lys Val Gln Asp Ile Lys Ala Arg Glu 
    290                 295                 300                 


Lys Asp Gly Lys Gly Arg Thr Ala Ser Pro Ile Asn Ser Pro Ala Arg 
305                 310                 315                 320 


Gly Thr Pro Ser Pro Lys Arg Met Pro Ser Gly Arg Gly Gly Arg Asp 
                325                 330                 335     


Arg Phe Thr Ala Glu Ser Tyr Thr Val Leu Gly Asp Thr Leu Ile Asp 
            340                 345                 350         


Gly Gly Glu His Tyr Trp Glu Val Arg Tyr Glu Pro Asp Ser Lys Ala 
        355                 360                 365             


Phe Gly Val Gly Val Ala Tyr Arg Ser Leu Gly Arg Phe Glu Gln Leu 
    370                 375                 380                 


Gly Lys Thr Ala Ala Ser Trp Cys Leu His Val Asn Asn Trp Leu Gln 
385                 390                 395                 400 


Val Ser Phe Thr Ala Lys His Ala Asn Lys Val Lys Val Leu Asp Ala 
                405                 410                 415     


Pro Val Pro Asp Cys Leu Gly Val His Cys Asp Phe His Gln Gly Leu 
            420                 425                 430         


Leu Ser Phe Tyr Asn Ala Arg Thr Lys Gln Val Leu His Thr Phe Lys 
        435                 440                 445             


Thr Arg Phe Thr Gln Pro Leu Leu Pro Ala Phe Thr Val Trp Cys Gly 
    450                 455                 460                 


Ser Phe Gln Val Thr Thr Gly Leu Gln Val Pro Ser Ala Val Arg Cys 
465                 470                 475                 480 


Leu Gln Lys Arg Gly Ser Ala Thr Ser Ser Ser Asn Thr Ser Leu Thr 
                485                 490                 495     


<210>  4201
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSD1L__Homo_sapiens__NP_001138785

<400>  4201

Met Asp Ser Gln Lys Tyr Cys Phe Lys Glu Asn Glu Asn Val Thr Val 
1               5                   10                  15      


Asp Lys Ala Cys Phe Leu Ile Ser Asn Ile Thr Ile Gly Pro Glu Ser 
            20                  25                  30          


Ile Asn Leu Gln Gln Glu Ala Leu Gln Arg Ile Ile Ser Thr Leu Ala 
        35                  40                  45              


Asn Lys Asn Asp Glu Ile Gln Asn Phe Ile Asp Thr Leu His His Thr 
    50                  55                  60                  


Leu Lys Gly Val Gln Glu Asn Ser Ser Asn Ile Leu Ser Glu Leu Asp 
65                  70                  75                  80  


Glu Glu Phe Asp Ser Leu Tyr Ser Ile Leu Asp Glu Val Lys Glu Ser 
                85                  90                  95      


Met Ile Asn Cys Ile Lys Gln Glu Gln Ala Arg Lys Ser Gln Glu Leu 
            100                 105                 110         


Gln Ser Gln Ile Ser Gln Cys Asn Asn Ala Leu Glu Asn Ser Glu Glu 
        115                 120                 125             


Leu Leu Glu Phe Ala Thr Arg Ser Leu Asp Ile Lys Glu Pro Glu Glu 
    130                 135                 140                 


Phe Ser Lys Ala Ala Arg Gln Ile Lys Asp Arg Val Thr Met Ala Ser 
145                 150                 155                 160 


Ala Phe Arg Leu Ser Leu Lys Pro Lys Val Ser Asp Asn Met Thr His 
                165                 170                 175     


Leu Met Val Asp Phe Ser Gln Glu Arg Gln Met Leu Gln Thr Leu Lys 
            180                 185                 190         


Phe Leu Pro Val Pro Lys Ala Pro Glu Ile Asp Pro Val Glu Cys Leu 
        195                 200                 205             


Val Ala Asp Asn Ser Val Thr Val Ala Trp Arg Met Pro Glu Glu Asp 
    210                 215                 220                 


Asn Lys Ile Asp His Phe Ile Leu Glu His Arg Lys Thr Asn Phe Asp 
225                 230                 235                 240 


Gly Leu Pro Arg Val Lys Asp Glu Arg Cys Trp Glu Ile Ile Asp Asn 
                245                 250                 255     


Ile Lys Gly Thr Glu Tyr Thr Leu Ser Gly Leu Lys Phe Asp Ser Lys 
            260                 265                 270         


Tyr Met Asn Phe Arg Val Arg Ala Cys Asn Lys Ala Val Ala Gly Glu 
        275                 280                 285             


Tyr Ser Asp Pro Val Thr Leu Glu Thr Lys Ala Leu Asn Phe Asn Leu 
    290                 295                 300                 


Asp Asn Ser Ser Ser His Leu Asn Leu Lys Val Glu Asp Thr Cys Val 
305                 310                 315                 320 


Glu Trp Asp Pro Thr Gly Gly Lys Gly Gln Glu Ser Lys Ile Lys Gly 
                325                 330                 335     


Lys Glu Asn Lys Gly Arg Ser Gly Thr Pro Ser Pro Lys Arg Thr Ser 
            340                 345                 350         


Val Gly Ser Arg Pro Pro Ala Val Arg Gly Ser Arg Asp Arg Phe Thr 
        355                 360                 365             


Gly Glu Ser Tyr Thr Val Leu Gly Asp Thr Ala Ile Glu Ser Gly Gln 
    370                 375                 380                 


His Tyr Trp Glu Val Lys Ala Gln Lys Asp Cys Lys Ser Tyr Ser Val 
385                 390                 395                 400 


Gly Val Ala Tyr Lys Thr Leu Gly Lys Phe Asp Gln Leu Gly Lys Thr 
                405                 410                 415     


Asn Thr Ser Trp Cys Ile His Val Asn Asn Trp Leu Gln Asn Thr Phe 
            420                 425                 430         


Ala Ala Lys His Asn Asn Lys Val Lys Ala Leu Asp Val Thr Val Pro 
        435                 440                 445             


Glu Lys Ile Gly Val Phe Cys Asp Phe Asp Gly Gly Gln Leu Ser Phe 
    450                 455                 460                 


Tyr Asp Ala Asn Ser Lys Gln Leu Leu Tyr Ser Phe Lys Thr Lys Phe 
465                 470                 475                 480 


Thr Gln Pro Val Leu Pro Gly Phe Met Val Trp Cys Gly Gly Leu Ser 
                485                 490                 495     


Leu Ser Thr Gly Met Gln Val Pro Ser Ala Val Arg Thr Leu Gln Lys 
            500                 505                 510         


Ser Glu Asn Gly Met Thr Gly Ser Ala Ser Ser Leu Asn Asn Val Val 
        515                 520                 525             


Thr Gln 
    530 


<210>  4202
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSD2__Homo_sapiens__NP_001007123

<400>  4202

Met Glu Glu Glu Ser Gly Glu Glu Leu Gly Leu Asp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Asp Phe His Phe Tyr His Met Asp Leu Tyr Asp Ser Glu Asp Arg 
            20                  25                  30          


Leu His Leu Phe Pro Glu Glu Asn Thr Arg Met Arg Lys Val Val Gln 
        35                  40                  45              


Ala Glu Met Ala Asn Glu Ser Arg Gly Ala Gly Asp Gly Lys Ala Gln 
    50                  55                  60                  


Arg Asp Leu Gln Glu Glu Val Asp Glu Leu Val His Leu Tyr Gly Leu 
65                  70                  75                  80  


Glu Asp Asp His Glu Leu Gly Asp Glu Phe Val Asp Glu Asn Ile Pro 
                85                  90                  95      


Arg Thr Gly Val Ser Glu Tyr Pro Pro Tyr Met Met Lys Arg Arg Asp 
            100                 105                 110         


Pro Ala Arg Glu Gln Arg Asp Trp Arg Leu Ser Gly Glu Ala Ala Glu 
        115                 120                 125             


Ala Glu Asp Leu Gly Phe Gly Gly Trp Gly Ser Ala Gly Gln Cys Gln 
    130                 135                 140                 


Asp Leu Arg Glu Ala Tyr Arg Tyr Thr His Gly Arg Ala Ser Glu Glu 
145                 150                 155                 160 


Tyr Glu Cys Tyr Val Ile Pro Glu Glu Glu Asp Glu Glu Glu Ala Ala 
                165                 170                 175     


Asp Val Phe Cys Val Thr Cys Lys Thr Pro Ile Arg Ala Phe Gln Lys 
            180                 185                 190         


Val Phe Asp Glu His Lys Glu His Glu Val Ile Pro Leu Asn Glu Ala 
        195                 200                 205             


Leu Glu Ser Ala Lys Asp Glu Ile His Lys Asn Met Tyr Lys Leu Glu 
    210                 215                 220                 


Lys Gln Ile Ile Glu Met Glu Asn Phe Ala Asn His Leu Glu Glu Val 
225                 230                 235                 240 


Phe Ile Thr Val Glu Glu Asn Phe Gly Lys Gln Glu Gln Asn Phe Glu 
                245                 250                 255     


Ser His Tyr Asn Glu Ile Leu Glu Thr Leu Ala Gln Lys Tyr Glu Glu 
            260                 265                 270         


Lys Ile Gln Ala Leu Gly Glu Lys Lys Lys Glu Lys Leu Glu Ala Leu 
        275                 280                 285             


Tyr Gly Gln Leu Val Ser Cys Gly Glu Asn Leu Asp Thr Cys Lys Glu 
    290                 295                 300                 


Leu Met Glu Thr Ile Glu Glu Met Cys His Glu Glu Lys Val Asp Phe 
305                 310                 315                 320 


Ile Lys Asp Ala Val Ala Met Ala Asp Arg Leu Gly Lys Phe Leu Lys 
                325                 330                 335     


Thr Lys Thr Asp Val Glu Ile Ser Ala Gln Pro Glu Phe Glu Asp Gln 
            340                 345                 350         


Thr Leu Asp Phe Ser Asp Val Glu Gln Leu Met Gly Ser Ile Asn Thr 
        355                 360                 365             


Ile Pro Ala Pro Ser Ala Pro Val Ile Asn Pro Gln Val Pro Asn Ser 
    370                 375                 380                 


Ala Thr Gly Ser Ser Val Arg Val Cys Trp Ser Leu Tyr Ser Asp Asp 
385                 390                 395                 400 


Thr Val Glu Ser Tyr Gln Leu Ser Tyr Arg Pro Val Gln Asp Ser Ser 
                405                 410                 415     


Pro Gly Thr Asp Gln Ala Glu Phe Thr Val Thr Val Lys Glu Thr Tyr 
            420                 425                 430         


Cys Ser Val Thr Asn Leu Val Pro Asn Thr Gln Tyr Glu Phe Trp Val 
        435                 440                 445             


Thr Ala His Asn Arg Ala Gly Pro Ser Pro Ser Ser Glu Arg Ala Val 
    450                 455                 460                 


Tyr Met Thr Ala Pro Ser Pro Pro Ile Ile Lys Thr Lys Glu Ile Arg 
465                 470                 475                 480 


Ser Cys Glu Glu Ala Val Leu Ile Cys Trp Glu Ser Gly Asn Leu Asn 
                485                 490                 495     


Pro Val Asp Ser Tyr Thr Val Glu Leu Thr Gln Ala Glu Ser Pro Glu 
            500                 505                 510         


Ala Ser Gly Val Thr Glu Ser Val Val Gly Ile Pro Thr Cys Glu Ser 
        515                 520                 525             


Val Val Gln Leu Gln Pro Gly Arg Ser Tyr Ile Ile Tyr Val Arg Ala 
    530                 535                 540                 


Leu Asn Met Gly Gly Pro Ser Val Arg Ser Glu Pro Ala Thr Val His 
545                 550                 555                 560 


Thr Ile Gly Ser Tyr Phe Arg Leu Asn Lys Asp Thr Cys His Pro Trp 
                565                 570                 575     


Leu Thr Ile Ser Glu Asp Gly Leu Thr Ala Val Arg Ser Glu Arg Arg 
            580                 585                 590         


Thr Pro Ala Arg Glu Leu Ser Pro Ser Asp Thr His Phe Thr Arg Cys 
        595                 600                 605             


Val Ala Val Met Gly Asn Leu Ile Pro Val Arg Gly His His Tyr Trp 
    610                 615                 620                 


Glu Val Glu Val Asp Glu His Leu Asp Tyr Arg Val Gly Val Ala Phe 
625                 630                 635                 640 


Ala Asp Val Arg Lys Gln Glu Asp Leu Gly Ala Asn Cys Leu Ser Trp 
                645                 650                 655     


Cys Met Arg His Thr Phe Ala Ser Ser Arg His Lys Tyr Glu Phe Leu 
            660                 665                 670         


His Asn Arg Thr Thr Pro Asp Ile Arg Ile Thr Val Pro Pro Lys Lys 
        675                 680                 685             


Ile Gly Ile Leu Leu Asp Tyr Glu His Ser Lys Leu Ser Phe Phe Asn 
    690                 695                 700                 


Val Asp Leu Ser Gln His Leu Tyr Thr Phe Ser Cys Gln Leu His Glu 
705                 710                 715                 720 


Phe Val His Pro Cys Phe Ser Leu Glu Lys Pro Gly Cys Leu Lys Val 
                725                 730                 735     


His Asn Gly Ile Ser Met Pro Lys His Val Thr Phe Tyr 
            740                 745                 


<210>  4203
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHB__Homo_sapiens__NP_001018090

<400>  4203

Met Lys Thr Leu Gln Phe Phe Phe Leu Phe Cys Cys Trp Lys Ala Ile 
1               5                   10                  15      


Cys Cys Asn Ser Cys Glu Leu Thr Asn Ile Thr Ile Ala Ile Glu Lys 
            20                  25                  30          


Glu Glu Cys Arg Phe Cys Ile Ser Ile Asn Thr Thr Trp Cys Ala Gly 
        35                  40                  45              


Tyr Cys Tyr Thr Arg Asp Leu Val Tyr Lys Asp Pro Ala Arg Pro Lys 
    50                  55                  60                  


Ile Gln Lys Thr Cys Thr Phe Lys Glu Leu Val Tyr Glu Thr Val Arg 
65                  70                  75                  80  


Val Pro Gly Cys Ala His His Ala Asp Ser Leu Tyr Thr Tyr Pro Val 
                85                  90                  95      


Ala Thr Gln Cys His Cys Gly Lys Cys Asp Ser Asp Ser Thr Asp Cys 
            100                 105                 110         


Thr Val Arg Gly Leu Gly Pro Ser Tyr Cys Ser Phe Gly Glu Met Lys 
        115                 120                 125             


Glu 
    


<210>  4204
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSHR__Homo_sapiens__NP_000136

<400>  4204

Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Asp 
    210                 215                 220                 


Ile Ser Arg Thr Arg Ile His Ser Leu Pro Ser Tyr Gly Leu Glu Asn 
225                 230                 235                 240 


Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr Asn Leu Lys Lys Leu Pro 
                245                 250                 255     


Thr Leu Glu Lys Leu Val Ala Leu Met Glu Ala Ser Leu Thr Tyr Pro 
            260                 265                 270         


Ser His Cys Cys Ala Phe Ala Asn Trp Arg Arg Gln Ile Ser Glu Leu 
        275                 280                 285             


His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met 
    290                 295                 300                 


Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser 
305                 310                 315                 320 


Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp 
                325                 330                 335     


Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala 
            340                 345                 350         


Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu 
        355                 360                 365             


Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu 
    370                 375                 380                 


Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg Phe Leu 
385                 390                 395                 400 


Met Cys Asn Leu Ala Phe Ala Asp Leu Cys Ile Gly Ile Tyr Leu Leu 
                405                 410                 415     


Leu Ile Ala Ser Val Asp Ile His Thr Lys Ser Gln Tyr His Asn Tyr 
            420                 425                 430         


Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys Asp Ala Ala Gly Phe Phe 
        435                 440                 445             


Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Ala Ile Thr 
    450                 455                 460                 


Leu Glu Arg Trp His Thr Ile Thr His Ala Met Gln Leu Asp Cys Lys 
465                 470                 475                 480 


Val Gln Leu Arg His Ala Ala Ser Val Met Val Met Gly Trp Ile Phe 
                485                 490                 495     


Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe Gly Ile Ser Ser Tyr Met 
            500                 505                 510         


Lys Val Ser Ile Cys Leu Pro Met Asp Ile Asp Ser Pro Leu Ser Gln 
        515                 520                 525             


Leu Tyr Val Met Ser Leu Leu Val Leu Asn Val Leu Ala Phe Val Val 
    530                 535                 540                 


Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu Thr Val Arg Asn Pro Asn 
545                 550                 555                 560 


Ile Val Ser Ser Ser Ser Asp Thr Arg Ile Ala Lys Arg Met Ala Met 
                565                 570                 575     


Leu Ile Phe Thr Asp Phe Leu Cys Met Ala Pro Ile Ser Phe Phe Ala 
            580                 585                 590         


Ile Ser Ala Ser Leu Lys Val Pro Leu Ile Thr Val Ser Lys Ala Lys 
        595                 600                 605             


Ile Leu Leu Val Leu Phe His Pro Ile Asn Ser Cys Ala Asn Pro Phe 
    610                 615                 620                 


Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg Arg Asp Phe Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln Ala Gln Ile Tyr Arg Thr 
                645                 650                 655     


Glu Thr Ser Ser Thr Val His Asn Thr His Pro Arg Asn Gly His Cys 
            660                 665                 670         


Ser Ser Ala Pro Arg Val Thr Ser Gly Ser Thr Tyr Ile Leu Val Pro 
        675                 680                 685             


Leu Ser His Leu Ala Gln Asn 
    690                 695 


<210>  4205
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSIP1__Homo_sapiens__XP_011519608

<400>  4205

Met Asp Ile Ile Lys Gly Asn Leu Asp Gly Ile Ser Lys Pro Ala Ser 
1               5                   10                  15      


Asn Ser Arg Ile Arg Pro Gly Ser Arg Ser Ser Asn Ala Ser Leu Glu 
            20                  25                  30          


Val Leu Ser Thr Glu Pro Gly Ser Phe Lys Val Asp Thr Ala Ser Asn 
        35                  40                  45              


Leu Asn Ser Gly Lys Glu Asp His Ser Glu Ser Ser Asn Thr Glu Asn 
    50                  55                  60                  


Arg Arg Thr Ser Asn Asp Asp Lys Gln Glu Ser Cys Ser Glu Lys Ile 
65                  70                  75                  80  


Lys Leu Ala Glu Glu Gly Ser Asp Glu Asp Leu Asp Leu Val Gln His 
                85                  90                  95      


Gln Ile Ile Ser Glu Cys Ser Asp Glu Pro Lys Leu Lys Glu Leu Asp 
            100                 105                 110         


Ser Gln Leu Gln Asp Ala Ile Gln Lys Met Lys Lys Leu Asp Lys Ile 
        115                 120                 125             


Leu Ala Lys Lys Gln Arg Arg Glu Lys Glu Ile Lys Lys Gln Gly Leu 
    130                 135                 140                 


Glu Met Arg Ile Lys Leu Trp Glu Glu Ile Lys Ser Ala Lys Tyr Ser 
145                 150                 155                 160 


Glu Ala Trp Gln Ser Lys Glu Glu Met Glu Asn Thr Lys Lys Phe Leu 
                165                 170                 175     


Ser Leu Thr Ala Val Ser Glu Glu Thr Val Gly Pro Ser His Glu Glu 
            180                 185                 190         


Glu Asp Thr Phe Ser Ser Val Phe His Thr Gln Ile Pro Pro Glu Glu 
        195                 200                 205             


Tyr Glu Met Gln Met Gln Lys Leu Asn Lys Asp Phe Thr Cys Asp Val 
    210                 215                 220                 


Glu Arg Asn Glu Ser Leu Ile Lys Ser Gly Lys Lys Pro Phe Ser Asn 
225                 230                 235                 240 


Thr Glu Lys Ile Glu Leu Arg Gly Lys His Asn Gln Asp Phe Ile Lys 
                245                 250                 255     


Arg Asn Ile Glu Leu Ala Lys Glu Ser Arg Asn Pro Val Val Met Val 
            260                 265                 270         


Asp Arg Glu Lys Lys Arg Leu Val Glu Leu Leu Lys Asp Leu Asp Glu 
        275                 280                 285             


Lys Asp Ser Gly Leu Ser Ser Ser Glu Gly Asp Gln Ser Gly Trp Val 
    290                 295                 300                 


Val Pro Val Lys Gly Tyr Glu Leu Ala Val Thr Gln His Gln Gln Leu 
305                 310                 315                 320 


Ala Glu Ile Asp Ile Lys Leu Gln Glu Leu Ser Ala Ala Ser Pro Thr 
                325                 330                 335     


Ile Ser Ser Phe Ser Pro Arg Leu Glu Asn Arg Asn Asn Gln Lys Pro 
            340                 345                 350         


Asp Arg Asp Gly Glu Arg Asn Met Glu Val Thr Pro Gly Glu Lys Ile 
        355                 360                 365             


Leu Arg Asn Thr Lys Glu Gln Arg Asp Leu His Asn Arg Leu Arg Glu 
    370                 375                 380                 


Ile Asp Glu Lys Leu Lys Met Met Lys Glu Asn Val Leu Glu Ser Thr 
385                 390                 395                 400 


Ser Cys Leu Ser Glu Glu Gln Leu Lys Cys Leu Leu Asp Glu Cys Ile 
                405                 410                 415     


Leu Lys Gln Lys Ser Ile Ile Lys Leu Ser Ser Glu Arg Lys Lys Glu 
            420                 425                 430         


Asp Ile Glu Asp Val Thr Pro Val Phe Pro Gln Leu Ser Arg Ser Ile 
        435                 440                 445             


Ile Ser Lys Leu Leu Asn Glu Ser Glu Thr Lys Val Gln Lys Thr Glu 
    450                 455                 460                 


Val Glu Asp Ala Asp Met Leu Glu Ser Glu Glu Cys Glu Ala Ser Lys 
465                 470                 475                 480 


Gly Tyr Tyr Leu Thr Lys Ala Leu Thr Gly His Asn Met Ser Glu Ala 
                485                 490                 495     


Leu Val Thr Glu Ala Glu Asn Met Lys Cys Leu Gln Phe Ser Lys Asp 
            500                 505                 510         


Val Ile Ile Ser Asp Thr Lys Asp Tyr Phe Met Ser Lys Thr Leu Gly 
        515                 520                 525             


Ile Gly Arg Leu Lys Arg Pro Ser Phe Leu Asp Asp Pro Leu Tyr Gly 
    530                 535                 540                 


Ile Ser Val Ser Leu Ser Ser Glu Asp Gln His Leu Lys Leu Ser Ser 
545                 550                 555                 560 


Pro Glu Asn Thr Ile Ala Asp Glu Gln Glu Thr Lys Asp Ala Ala Glu 
                565                 570                 575     


Glu Cys Lys Glu Pro 
            580     


<210>  4206
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FST__Homo_sapiens__NP_006341

<400>  4206

Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
            20                  25                  30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
        35                  40                  45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
    50                  55                  60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                  70                  75                  80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                85                  90                  95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
            100                 105                 110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
        115                 120                 125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
    130                 135                 140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                 150                 155                 160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                165                 170                 175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
            180                 185                 190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
        195                 200                 205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
    210                 215                 220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                 230                 235                 240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                245                 250                 255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
            260                 265                 270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
        275                 280                 285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
    290                 295                 300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
305                 310                 315         


<210>  4207
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSTL1__Homo_sapiens__NP_009016

<400>  4207

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
            20                  25                  30          


Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
        35                  40                  45              


Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
    50                  55                  60                  


Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
65                  70                  75                  80  


Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                85                  90                  95      


His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
            100                 105                 110         


Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
        115                 120                 125             


Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
    130                 135                 140                 


Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
145                 150                 155                 160 


Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                165                 170                 175     


Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
            180                 185                 190         


Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
        195                 200                 205             


Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
    210                 215                 220                 


Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
225                 230                 235                 240 


Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                245                 250                 255     


Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
            260                 265                 270         


Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
        275                 280                 285             


Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
    290                 295                 300                 


Thr Lys Glu Ile 
305             


<210>  4208
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSTL3__Homo_sapiens__NP_005851

<400>  4208

Met Arg Pro Gly Ala Pro Gly Pro Leu Trp Pro Leu Pro Trp Gly Ala 
1               5                   10                  15      


Leu Ala Trp Ala Val Gly Phe Val Ser Ser Met Gly Ser Gly Asn Pro 
            20                  25                  30          


Ala Pro Gly Gly Val Cys Trp Leu Gln Gln Gly Gln Glu Ala Thr Cys 
        35                  40                  45              


Ser Leu Val Leu Gln Thr Asp Val Thr Arg Ala Glu Cys Cys Ala Ser 
    50                  55                  60                  


Gly Asn Ile Asp Thr Ala Trp Ser Asn Leu Thr His Pro Gly Asn Lys 
65                  70                  75                  80  


Ile Asn Leu Leu Gly Phe Leu Gly Leu Val His Cys Leu Pro Cys Lys 
                85                  90                  95      


Asp Ser Cys Asp Gly Val Glu Cys Gly Pro Gly Lys Ala Cys Arg Met 
            100                 105                 110         


Leu Gly Gly Arg Pro Arg Cys Glu Cys Ala Pro Asp Cys Ser Gly Leu 
        115                 120                 125             


Pro Ala Arg Leu Gln Val Cys Gly Ser Asp Gly Ala Thr Tyr Arg Asp 
    130                 135                 140                 


Glu Cys Glu Leu Arg Ala Ala Arg Cys Arg Gly His Pro Asp Leu Ser 
145                 150                 155                 160 


Val Met Tyr Arg Gly Arg Cys Arg Lys Ser Cys Glu His Val Val Cys 
                165                 170                 175     


Pro Arg Pro Gln Ser Cys Val Val Asp Gln Thr Gly Ser Ala His Cys 
            180                 185                 190         


Val Val Cys Arg Ala Ala Pro Cys Pro Val Pro Ser Ser Pro Gly Gln 
        195                 200                 205             


Glu Leu Cys Gly Asn Asn Asn Val Thr Tyr Ile Ser Ser Cys His Met 
    210                 215                 220                 


Arg Gln Ala Thr Cys Phe Leu Gly Arg Ser Ile Gly Val Arg His Ala 
225                 230                 235                 240 


Gly Ser Cys Ala Gly Thr Pro Glu Glu Pro Pro Gly Gly Glu Ser Ala 
                245                 250                 255     


Glu Glu Glu Glu Asn Phe Val 
            260             


<210>  4209
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSTL4__Homo_sapiens__NP_055897

<400>  4209

Met Lys Pro Gly Gly Phe Trp Leu His Leu Thr Leu Leu Gly Ala Ser 
1               5                   10                  15      


Leu Pro Ala Ala Leu Gly Trp Met Asp Pro Gly Thr Ser Arg Gly Pro 
            20                  25                  30          


Asp Val Gly Val Gly Glu Ser Gln Ala Glu Glu Pro Arg Ser Phe Glu 
        35                  40                  45              


Val Thr Arg Arg Glu Gly Leu Ser Ser His Asn Glu Leu Leu Ala Ser 
    50                  55                  60                  


Cys Gly Lys Lys Phe Cys Ser Arg Gly Ser Arg Cys Val Leu Ser Arg 
65                  70                  75                  80  


Lys Thr Gly Glu Pro Glu Cys Gln Cys Leu Glu Ala Cys Arg Pro Ser 
                85                  90                  95      


Tyr Val Pro Val Cys Gly Ser Asp Gly Arg Phe Tyr Glu Asn His Cys 
            100                 105                 110         


Lys Leu His Arg Ala Ala Cys Leu Leu Gly Lys Arg Ile Thr Val Ile 
        115                 120                 125             


His Ser Lys Asp Cys Phe Leu Lys Gly Asp Thr Cys Thr Met Ala Gly 
    130                 135                 140                 


Tyr Ala Arg Leu Lys Asn Val Leu Leu Ala Leu Gln Thr Arg Leu Gln 
145                 150                 155                 160 


Pro Leu Gln Glu Gly Asp Ser Arg Gln Asp Pro Ala Ser Gln Lys Arg 
                165                 170                 175     


Leu Leu Val Glu Ser Leu Phe Arg Asp Leu Asp Ala Asp Gly Asn Gly 
            180                 185                 190         


His Leu Ser Ser Ser Glu Leu Ala Gln His Val Leu Lys Lys Gln Asp 
        195                 200                 205             


Leu Asp Glu Asp Leu Leu Gly Cys Ser Pro Gly Asp Leu Leu Arg Phe 
    210                 215                 220                 


Asp Asp Tyr Asn Ser Asp Ser Ser Leu Thr Leu Arg Glu Phe Tyr Met 
225                 230                 235                 240 


Ala Phe Gln Val Val Gln Leu Ser Leu Ala Pro Glu Asp Arg Val Ser 
                245                 250                 255     


Val Thr Thr Val Thr Val Gly Leu Ser Thr Val Leu Thr Cys Ala Val 
            260                 265                 270         


His Gly Asp Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Gly Leu Thr 
        275                 280                 285             


Leu Asn Phe Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Glu Asp Asp 
    290                 295                 300                 


Ser Leu Tyr Ile Thr Lys Val Thr Thr Ile His Met Gly Asn Tyr Thr 
305                 310                 315                 320 


Cys His Ala Ser Gly His Glu Gln Leu Phe Gln Thr His Val Leu Gln 
                325                 330                 335     


Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Gln 
            340                 345                 350         


Glu Pro Gly Val Ala Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro 
        355                 360                 365             


Met Pro Arg Ile Thr Trp Leu Lys Asn Gly Val Asp Val Ser Thr Gln 
    370                 375                 380                 


Met Ser Lys Gln Leu Ser Leu Leu Ala Asn Gly Ser Glu Leu His Ile 
385                 390                 395                 400 


Ser Ser Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys 
                405                 410                 415     


Asn Glu Val Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Ile Glu Asp 
            420                 425                 430         


Ser Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu 
        435                 440                 445             


Ser Val Gly Asn Met Phe Tyr Val Phe Ser Asp Asp Gly Ile Ile Val 
    450                 455                 460                 


Ile His Pro Val Asp Cys Glu Ile Gln Arg His Leu Lys Pro Thr Glu 
465                 470                 475                 480 


Lys Ile Phe Met Ser Tyr Glu Glu Ile Cys Pro Gln Arg Glu Lys Asn 
                485                 490                 495     


Ala Thr Gln Pro Cys Gln Trp Val Ser Ala Val Asn Val Arg Asn Arg 
            500                 505                 510         


Tyr Ile Tyr Val Ala Gln Pro Ala Leu Ser Arg Val Leu Val Val Asp 
        515                 520                 525             


Ile Gln Ala Gln Lys Val Leu Gln Ser Ile Gly Val Asp Pro Leu Pro 
    530                 535                 540                 


Ala Lys Leu Ser Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser 
545                 550                 555                 560 


Trp Gly Asp Val His Lys Ser Arg Pro Ser Leu Gln Val Ile Thr Glu 
                565                 570                 575     


Ala Ser Thr Gly Gln Ser Gln His Leu Ile Arg Thr Pro Phe Ala Gly 
            580                 585                 590         


Val Asp Asp Phe Phe Ile Pro Pro Thr Asn Leu Ile Ile Asn His Ile 
        595                 600                 605             


Arg Phe Gly Phe Ile Phe Asn Lys Ser Asp Pro Ala Val His Lys Val 
    610                 615                 620                 


Asp Leu Glu Thr Met Met Pro Leu Lys Thr Ile Gly Leu His His His 
625                 630                 635                 640 


Gly Cys Val Pro Gln Ala Met Ala His Thr His Leu Gly Gly Tyr Phe 
                645                 650                 655     


Phe Ile Gln Cys Arg Gln Asp Ser Pro Ala Ser Ala Ala Arg Gln Leu 
            660                 665                 670         


Leu Val Asp Ser Val Thr Asp Ser Val Leu Gly Pro Asn Gly Asp Val 
        675                 680                 685             


Thr Gly Thr Pro His Thr Ser Pro Asp Gly Arg Phe Ile Val Ser Ala 
    690                 695                 700                 


Ala Ala Asp Ser Pro Trp Leu His Val Gln Glu Ile Thr Val Arg Gly 
705                 710                 715                 720 


Glu Ile Gln Thr Leu Tyr Asp Leu Gln Ile Asn Ser Gly Ile Ser Asp 
                725                 730                 735     


Leu Ala Phe Gln Arg Ser Phe Thr Glu Ser Asn Gln Tyr Asn Ile Tyr 
            740                 745                 750         


Ala Ala Leu His Thr Glu Pro Asp Leu Leu Phe Leu Glu Leu Ser Thr 
        755                 760                 765             


Gly Lys Val Gly Met Leu Lys Asn Leu Lys Glu Pro Pro Ala Gly Pro 
    770                 775                 780                 


Ala Gln Pro Trp Gly Gly Thr His Arg Ile Met Arg Asp Ser Gly Leu 
785                 790                 795                 800 


Phe Gly Gln Tyr Leu Leu Thr Pro Ala Arg Glu Ser Leu Phe Leu Ile 
                805                 810                 815     


Asn Gly Arg Gln Asn Thr Leu Arg Cys Glu Val Ser Gly Ile Lys Gly 
            820                 825                 830         


Gly Thr Thr Val Val Trp Val Gly Glu Val 
        835                 840         


<210>  4210
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FSTL5__Homo_sapiens__NP_001121899

<400>  4210

Met Phe Lys Cys Trp Ser Val Val Leu Val Leu Gly Phe Ile Phe Leu 
1               5                   10                  15      


Glu Ser Glu Gly Arg Pro Thr Lys Glu Gly Gly Tyr Gly Leu Lys Ser 
            20                  25                  30          


Tyr Gln Pro Leu Met Arg Leu Arg His Lys Glu Lys Asn Gln Glu Ser 
        35                  40                  45              


Ser Arg Val Lys Gly Phe Met Ile Gln Asp Gly Pro Phe Gly Ser Cys 
    50                  55                  60                  


Glu Asn Lys Tyr Cys Gly Leu Gly Arg His Cys Val Thr Ser Arg Glu 
65                  70                  75                  80  


Thr Gly Gln Ala Glu Cys Ala Cys Met Asp Leu Cys Lys Arg His Tyr 
                85                  90                  95      


Lys Pro Val Cys Gly Ser Asp Gly Glu Phe Tyr Glu Asn His Cys Glu 
            100                 105                 110         


Val His Arg Ala Ala Cys Leu Lys Lys Gln Lys Ile Thr Ile Val His 
        115                 120                 125             


Asn Glu Asp Cys Phe Phe Lys Gly Asp Lys Cys Lys Thr Thr Glu Tyr 
    130                 135                 140                 


Ser Lys Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys Tyr Ile 
145                 150                 155                 160 


Met Gln Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg Lys Lys 
                165                 170                 175     


Leu Leu Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser Asn Gly 
            180                 185                 190         


Leu Val Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu Glu Leu 
        195                 200                 205             


Gly Lys Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys Tyr Asp 
    210                 215                 220                 


Asp Phe Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr Arg Ala 
225                 230                 235                 240 


Phe Gln Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu Ser Ile 
                245                 250                 255     


Thr Ala Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala Ile Gln 
            260                 265                 270         


Gly Thr Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile Ile Leu 
        275                 280                 285             


Asn Asn Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp Gly Ser 
    290                 295                 300                 


Leu Tyr Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr Thr Cys 
305                 310                 315                 320 


Tyr Ala Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe Gln Val 
                325                 330                 335     


Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Arg Glu 
            340                 345                 350         


Pro Gly Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro Lys 
        355                 360                 365             


Pro Gln Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro Lys Leu 
    370                 375                 380                 


Ser Lys Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His Ile Ser 
385                 390                 395                 400 


Asn Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys Asn 
                405                 410                 415     


Glu Ala Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu Asp Ser 
            420                 425                 430         


Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu Gly 
        435                 440                 445             


Ile Gly Asn Met Phe Tyr Val Phe Tyr Glu Asp Gly Ile Lys Val Ile 
    450                 455                 460                 


Gln Pro Ile Glu Cys Glu Phe Gln Arg His Ile Lys Pro Ser Glu Lys 
465                 470                 475                 480 


Leu Leu Gly Phe Gln Asp Glu Val Cys Pro Lys Ala Glu Gly Asp Glu 
                485                 490                 495     


Val Gln Arg Cys Val Trp Ala Ser Ala Val Asn Val Lys Asp Lys Phe 
            500                 505                 510         


Ile Tyr Val Ala Gln Pro Thr Leu Asp Arg Val Leu Ile Val Asp Val 
        515                 520                 525             


Gln Ser Gln Lys Val Val Gln Ala Val Ser Thr Asp Pro Val Pro Val 
    530                 535                 540                 


Lys Leu His Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser Trp 
545                 550                 555                 560 


Gly Thr Leu Glu Lys Thr Ser Pro Thr Leu Gln Val Ile Thr Leu Ala 
                565                 570                 575     


Ser Gly Asn Val Pro His His Thr Ile His Thr Gln Pro Val Gly Lys 
            580                 585                 590         


Gln Phe Asp Arg Val Asp Asp Phe Phe Ile Pro Thr Thr Thr Leu Ile 
        595                 600                 605             


Ile Thr His Met Arg Phe Gly Phe Ile Leu His Lys Asp Glu Ala Ala 
    610                 615                 620                 


Leu Gln Lys Ile Asp Leu Glu Thr Met Ser Tyr Ile Lys Thr Ile Asn 
625                 630                 635                 640 


Leu Lys Asp Tyr Lys Cys Val Pro Gln Ser Leu Ala Tyr Thr His Leu 
                645                 650                 655     


Gly Gly Tyr Tyr Phe Ile Gly Cys Lys Pro Asp Ser Thr Gly Ala Val 
            660                 665                 670         


Ser Pro Gln Val Met Val Asp Gly Val Thr Asp Ser Val Ile Gly Phe 
        675                 680                 685             


Asn Ser Asp Val Thr Gly Thr Pro Tyr Val Ser Pro Asp Gly His Tyr 
    690                 695                 700                 


Leu Val Ser Ile Asn Asp Val Lys Gly Leu Val Arg Val Gln Tyr Ile 
705                 710                 715                 720 


Thr Ile Arg Gly Glu Ile Gln Glu Ala Phe Asp Ile Tyr Thr Asn Leu 
                725                 730                 735     


His Ile Ser Asp Leu Ala Phe Gln Pro Ser Phe Thr Glu Ala His Gln 
            740                 745                 750         


Tyr Asn Ile Tyr Gly Ser Ser Ser Thr Gln Thr Asp Val Leu Phe Val 
        755                 760                 765             


Glu Leu Ser Ser Gly Lys Val Lys Met Ile Lys Ser Leu Lys Glu Pro 
    770                 775                 780                 


Leu Lys Ala Glu Glu Trp Pro Trp Asn Arg Lys Asn Arg Gln Ile Gln 
785                 790                 795                 800 


Asp Ser Gly Leu Phe Gly Gln Tyr Leu Met Thr Pro Ser Lys Asp Ser 
                805                 810                 815     


Leu Phe Ile Leu Asp Gly Arg Leu Asn Lys Leu Asn Cys Glu Ile Thr 
            820                 825                 830         


Glu Val Glu Lys Gly Asn Thr Val Ile Trp Val Gly Asp Ala 
        835                 840                 845     


<210>  4211
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTCD__Homo_sapiens__NP_996848

<400>  4211

Met Ser Gln Leu Val Glu Cys Val Pro Asn Phe Ser Glu Gly Lys Asn 
1               5                   10                  15      


Gln Glu Val Ile Asp Ala Ile Ser Gly Ala Ile Thr Gln Thr Pro Gly 
            20                  25                  30          


Cys Val Leu Leu Asp Val Asp Ala Gly Pro Ser Thr Asn Arg Thr Val 
        35                  40                  45              


Tyr Thr Phe Val Gly Pro Pro Glu Cys Val Val Glu Gly Ala Leu Asn 
    50                  55                  60                  


Ala Ala Arg Val Ala Ser Arg Leu Ile Asp Met Ser Arg His Gln Gly 
65                  70                  75                  80  


Glu His Pro Arg Met Gly Ala Leu Asp Val Cys Pro Phe Ile Pro Val 
                85                  90                  95      


Arg Gly Val Ser Val Asp Glu Cys Val Leu Cys Ala Gln Ala Phe Gly 
            100                 105                 110         


Gln Arg Leu Ala Glu Glu Leu Asp Val Pro Val Tyr Leu Tyr Gly Glu 
        115                 120                 125             


Ala Ala Arg Met Asp Ser Arg Arg Thr Leu Pro Ala Ile Arg Ala Gly 
    130                 135                 140                 


Glu Tyr Glu Ala Leu Pro Lys Lys Leu Gln Gln Ala Asp Trp Ala Pro 
145                 150                 155                 160 


Asp Phe Gly Pro Ser Ser Phe Val Pro Ser Trp Gly Ala Thr Ala Thr 
                165                 170                 175     


Gly Ala Arg Lys Phe Leu Ile Ala Phe Asn Ile Asn Leu Leu Gly Thr 
            180                 185                 190         


Lys Glu Gln Ala His Arg Ile Ala Leu Asn Leu Arg Glu Gln Gly Arg 
        195                 200                 205             


Gly Lys Asp Gln Pro Gly Arg Leu Lys Lys Val Gln Gly Ile Gly Trp 
    210                 215                 220                 


Tyr Leu Asp Glu Lys Asn Leu Ala Gln Val Ser Thr Asn Leu Leu Asp 
225                 230                 235                 240 


Phe Glu Val Thr Ala Leu His Thr Val Tyr Glu Glu Thr Cys Arg Glu 
                245                 250                 255     


Ala Gln Glu Leu Ser Leu Pro Val Val Gly Ser Gln Leu Val Gly Leu 
            260                 265                 270         


Val Pro Leu Lys Ala Leu Leu Asp Ala Ala Ala Phe Tyr Cys Glu Lys 
        275                 280                 285             


Glu Asn Leu Phe Ile Leu Glu Glu Glu Gln Arg Ile Arg Leu Val Val 
    290                 295                 300                 


Ser Arg Leu Gly Leu Asp Ser Leu Cys Pro Phe Ser Pro Lys Glu Arg 
305                 310                 315                 320 


Ile Ile Glu Tyr Leu Val Pro Glu Arg Gly Pro Glu Arg Gly Leu Gly 
                325                 330                 335     


Ser Lys Ser Leu Arg Ala Phe Val Gly Glu Val Gly Ala Arg Ser Ala 
            340                 345                 350         


Ala Pro Gly Gly Gly Ser Val Ala Ala Ala Ala Ala Ala Met Gly Ala 
        355                 360                 365             


Ala Leu Gly Ser Met Val Gly Leu Met Thr Tyr Gly Arg Arg Gln Phe 
    370                 375                 380                 


Gln Ser Leu Asp Thr Thr Met Arg Arg Leu Ile Pro Pro Phe Arg Glu 
385                 390                 395                 400 


Ala Ser Ala Lys Leu Thr Thr Leu Val Asp Ala Asp Ala Glu Ala Phe 
                405                 410                 415     


Thr Ala Tyr Leu Glu Ala Met Arg Leu Pro Lys Asn Thr Pro Glu Glu 
            420                 425                 430         


Lys Asp Arg Arg Thr Ala Ala Leu Gln Glu Gly Leu Arg Arg Ala Val 
        435                 440                 445             


Ser Val Pro Leu Thr Leu Ala Glu Thr Val Ala Ser Leu Trp Pro Ala 
    450                 455                 460                 


Leu Gln Glu Leu Ala Arg Cys Gly Asn Leu Ala Cys Arg Ser Asp Leu 
465                 470                 475                 480 


Gln Val Ala Ala Lys Ala Leu Glu Met Gly Val Phe Gly Ala Tyr Phe 
                485                 490                 495     


Asn Val Leu Ile Asn Leu Arg Asp Ile Thr Asp Glu Ala Phe Lys Asp 
            500                 505                 510         


Gln Ile His His Arg Val Ser Ser Leu Leu Gln Glu Ala Lys Thr Gln 
        515                 520                 525             


Ala Ala Leu Val Leu Asp Cys Leu Glu Thr Arg Gln Glu 
    530                 535                 540     


<210>  4212
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTH1__Homo_sapiens__NP_002023

<400>  4212

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  4213
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTL__Homo_sapiens__NP_000137

<400>  4213

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
145                 150                 155                 160 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 175 


<210>  4214
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTMT__Homo_sapiens__NP_803431

<400>  4214

Met Leu Ser Cys Phe Arg Leu Leu Ser Arg His Ile Ser Pro Ser Leu 
1               5                   10                  15      


Ala Ser Leu Arg Pro Val Arg Cys Cys Phe Ala Leu Pro Leu Arg Trp 
            20                  25                  30          


Ala Pro Gly Arg Pro Leu Asp Pro Arg Gln Ile Ala Pro Arg Arg Pro 
        35                  40                  45              


Leu Ala Ala Ala Ala Ser Ser Arg Asp Pro Thr Gly Pro Ala Ala Gly 
    50                  55                  60                  


Pro Ser Arg Val Arg Gln Asn Phe His Pro Asp Ser Glu Ala Ala Ile 
65                  70                  75                  80  


Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu Ser 
                85                  90                  95      


Met Ala Tyr Tyr Phe Ser Arg Asp Asp Val Ala Leu Asn Asn Phe Ser 
            100                 105                 110         


Arg Tyr Phe Leu His Gln Ser Arg Glu Glu Thr Glu His Ala Glu Lys 
        115                 120                 125             


Leu Met Arg Leu Gln Asn Gln Arg Gly Gly Arg Ile Arg Leu Gln Asp 
    130                 135                 140                 


Ile Lys Lys Pro Glu Gln Asp Asp Trp Glu Ser Gly Leu His Ala Met 
145                 150                 155                 160 


Glu Cys Ala Leu Leu Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu 
                165                 170                 175     


Leu His Ala Leu Ala Ser Asp Lys Gly Asp Pro His Leu Cys Asp Phe 
            180                 185                 190         


Leu Glu Thr Tyr Tyr Leu Asn Glu Gln Val Lys Ser Ile Lys Glu Leu 
        195                 200                 205             


Gly Asp His Val His Asn Leu Val Lys Met Gly Ala Pro Asp Ala Gly 
    210                 215                 220                 


Leu Ala Glu Tyr Leu Phe Asp Thr His Thr Leu Gly Asn Glu Asn Lys 
225                 230                 235                 240 


Gln Asn 
        


<210>  4215
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTO__Homo_sapiens__NP_001073901

<400>  4215

Met Lys Arg Thr Pro Thr Ala Glu Glu Arg Glu Arg Glu Ala Lys Lys 
1               5                   10                  15      


Leu Arg Leu Leu Glu Glu Leu Glu Asp Thr Trp Leu Pro Tyr Leu Thr 
            20                  25                  30          


Pro Lys Asp Asp Glu Phe Tyr Gln Gln Trp Gln Leu Lys Tyr Pro Lys 
        35                  40                  45              


Leu Ile Leu Arg Glu Ala Ser Ser Val Ser Glu Glu Leu His Lys Glu 
    50                  55                  60                  


Val Gln Glu Ala Phe Leu Thr Leu His Lys His Gly Cys Leu Phe Arg 
65                  70                  75                  80  


Asp Leu Val Arg Ile Gln Gly Lys Asp Leu Leu Thr Pro Val Ser Arg 
                85                  90                  95      


Ile Leu Ile Gly Asn Pro Gly Cys Thr Tyr Lys Tyr Leu Asn Thr Arg 
            100                 105                 110         


Leu Phe Thr Val Pro Trp Pro Val Lys Gly Ser Asn Ile Lys His Thr 
        115                 120                 125             


Glu Ala Glu Ile Ala Ala Ala Cys Glu Thr Phe Leu Lys Leu Asn Asp 
    130                 135                 140                 


Tyr Leu Gln Ile Glu Thr Ile Gln Ala Leu Glu Glu Leu Ala Ala Lys 
145                 150                 155                 160 


Glu Lys Ala Asn Glu Asp Ala Val Pro Leu Cys Met Ser Ala Asp Phe 
                165                 170                 175     


Pro Arg Val Gly Met Gly Ser Ser Tyr Asn Gly Gln Asp Glu Val Asp 
            180                 185                 190         


Ile Lys Ser Arg Ala Ala Tyr Asn Val Thr Leu Leu Asn Phe Met Asp 
        195                 200                 205             


Pro Gln Lys Met Pro Tyr Leu Lys Glu Glu Pro Tyr Phe Gly Met Gly 
    210                 215                 220                 


Lys Met Ala Val Ser Trp His His Asp Glu Asn Leu Val Asp Arg Ser 
225                 230                 235                 240 


Ala Val Ala Val Tyr Ser Tyr Ser Cys Glu Gly Pro Glu Glu Glu Ser 
                245                 250                 255     


Glu Asp Asp Ser His Leu Glu Gly Arg Asp Pro Asp Ile Trp His Val 
            260                 265                 270         


Gly Phe Lys Ile Ser Trp Asp Ile Glu Thr Pro Gly Leu Ala Ile Pro 
        275                 280                 285             


Leu His Gln Gly Asp Cys Tyr Phe Met Leu Asp Asp Leu Asn Ala Thr 
    290                 295                 300                 


His Gln His Cys Val Leu Ala Gly Ser Gln Pro Arg Phe Ser Ser Thr 
305                 310                 315                 320 


His Arg Val Ala Glu Cys Ser Thr Gly Thr Leu Asp Tyr Ile Leu Gln 
                325                 330                 335     


Arg Cys Gln Leu Ala Leu Gln Asn Val Cys Asp Asp Val Asp Asn Asp 
            340                 345                 350         


Asp Val Ser Leu Lys Ser Phe Glu Pro Ala Val Leu Lys Gln Gly Glu 
        355                 360                 365             


Glu Ile His Asn Glu Val Glu Phe Glu Trp Leu Arg Gln Phe Trp Phe 
    370                 375                 380                 


Gln Gly Asn Arg Tyr Arg Lys Cys Thr Asp Trp Trp Cys Gln Pro Met 
385                 390                 395                 400 


Ala Gln Leu Glu Ala Leu Trp Lys Lys Met Glu Gly Val Thr Asn Ala 
                405                 410                 415     


Val Leu His Glu Val Lys Arg Glu Gly Leu Pro Val Glu Gln Arg Asn 
            420                 425                 430         


Glu Ile Leu Thr Ala Ile Leu Ala Ser Leu Thr Ala Arg Gln Asn Leu 
        435                 440                 445             


Arg Arg Glu Trp His Ala Arg Cys Gln Ser Arg Ile Ala Arg Thr Leu 
    450                 455                 460                 


Pro Ala Asp Gln Lys Pro Glu Cys Arg Pro Tyr Trp Glu Lys Asp Asp 
465                 470                 475                 480 


Ala Ser Met Pro Leu Pro Phe Asp Leu Thr Asp Ile Val Ser Glu Leu 
                485                 490                 495     


Arg Gly Gln Leu Leu Glu Ala Lys Pro 
            500                 505 


<210>  4216
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTSJ1__Homo_sapiens__NP_001269086

<400>  4216

Met Ala Leu Asn Ile Ala Thr His Val Leu Lys Pro Gly Gly Cys Phe 
1               5                   10                  15      


Val Ala Lys Ile Phe Arg Gly Arg Asp Val Thr Leu Leu Tyr Ser Gln 
            20                  25                  30          


Leu Gln Val Phe Phe Ser Ser Val Leu Cys Ala Lys Pro Arg Ser Ser 
        35                  40                  45              


Arg Asn Ser Ser Ile Glu Ala Phe Ala Val Cys Gln Gly Tyr Asp Pro 
    50                  55                  60                  


Pro Glu Gly Phe Ile Pro Asp Leu Ser Lys Pro Leu Leu Asp His Ser 
65                  70                  75                  80  


Tyr Asp Pro Asp Phe Asn Gln Leu Asp Gly Pro Thr Arg Ile Ile Val 
                85                  90                  95      


Pro Phe Val Thr Cys Gly Asp Leu Ser Ser Tyr Asp Ser Asp Arg Ser 
            100                 105                 110         


Tyr Pro Leu Asp Leu Glu Gly Gly Ser Glu Tyr Lys Tyr Thr Pro Pro 
        115                 120                 125             


Thr Gln Pro Pro Ile Ser Pro Pro Tyr Gln Glu Ala Cys Thr Leu Lys 
    130                 135                 140                 


Arg Lys Gly Gln Leu Ala Lys Glu Ile Arg Pro Gln Asp Cys Pro Ile 
145                 150                 155                 160 


Ser Arg Val Asp Thr Phe Pro Gln Pro Leu Ala Ala Pro Gln Cys His 
                165                 170                 175     


Thr Leu Leu Ala Pro Glu Met Glu Asp Asn Glu Met Ser Cys Ser Pro 
            180                 185                 190         


<210>  4217
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTSJ2__Homo_sapiens__NP_037525

<400>  4217

Met Ala Gly Tyr Leu Lys Leu Val Cys Val Ser Phe Gln Arg Gln Gly 
1               5                   10                  15      


Phe His Thr Val Gly Ser Arg Cys Lys Asn Arg Thr Gly Ala Glu His 
            20                  25                  30          


Leu Trp Leu Thr Arg His Leu Arg Asp Pro Phe Val Lys Ala Ala Lys 
        35                  40                  45              


Val Glu Ser Tyr Arg Cys Arg Ser Ala Phe Lys Leu Leu Glu Val Asn 
    50                  55                  60                  


Glu Arg His Gln Ile Leu Arg Pro Gly Leu Arg Val Leu Asp Cys Gly 
65                  70                  75                  80  


Ala Ala Pro Gly Ala Trp Ser Gln Val Ala Val Gln Lys Val Asn Ala 
                85                  90                  95      


Ala Gly Thr Asp Pro Ser Ser Pro Val Gly Phe Val Leu Gly Val Asp 
            100                 105                 110         


Leu Leu His Ile Phe Pro Leu Glu Gly Ala Thr Phe Leu Cys Pro Ala 
        115                 120                 125             


Asp Val Thr Asp Pro Arg Thr Ser Gln Arg Ile Leu Glu Val Leu Pro 
    130                 135                 140                 


Gly Arg Arg Ala Asp Val Ile Leu Ser Asp Met Ala Pro Asn Ala Thr 
145                 150                 155                 160 


Gly Phe Arg Asp Leu Asp His Asp Arg Leu Ile Ser Leu Cys Leu Thr 
                165                 170                 175     


Leu Leu Ser Val Thr Pro Asp Ile Leu Gln Pro Gly Gly Thr Phe Leu 
            180                 185                 190         


Cys Lys Thr Trp Ala Gly Ser Gln Ser Arg Arg Leu Gln Arg Arg Leu 
        195                 200                 205             


Thr Glu Glu Phe Gln Asn Val Arg Ile Ile Lys Pro Glu Ala Ser Arg 
    210                 215                 220                 


Lys Glu Ser Ser Glu Val Tyr Phe Leu Ala Thr Gln Tyr His Gly Arg 
225                 230                 235                 240 


Lys Gly Thr Val Lys Gln 
                245     


<210>  4218
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTSJ3__Homo_sapiens__NP_060117

<400>  4218

Met Gly Lys Lys Gly Lys Val Gly Lys Ser Arg Arg Asp Lys Phe Tyr 
1               5                   10                  15      


His Leu Ala Lys Glu Thr Gly Tyr Arg Ser Arg Ser Ala Phe Lys Leu 
            20                  25                  30          


Ile Gln Leu Asn Arg Arg Phe Gln Phe Leu Gln Lys Ala Arg Ala Leu 
        35                  40                  45              


Leu Asp Leu Cys Ala Ala Pro Gly Gly Trp Leu Gln Val Ala Ala Lys 
    50                  55                  60                  


Phe Met Pro Val Ser Ser Leu Ile Val Gly Val Asp Leu Val Pro Ile 
65                  70                  75                  80  


Lys Pro Leu Pro Asn Val Val Thr Leu Gln Gln Asp Ile Thr Thr Glu 
                85                  90                  95      


Arg Cys Arg Gln Ala Leu Arg Lys Glu Leu Lys Thr Trp Lys Val Asp 
            100                 105                 110         


Val Val Leu Asn Asp Gly Ala Pro Asn Val Gly Ala Ser Trp Val His 
        115                 120                 125             


Asp Ala Tyr Ser Gln Ala His Leu Thr Leu Met Ala Leu Arg Leu Ala 
    130                 135                 140                 


Cys Asp Phe Leu Ala Arg Gly Gly Ser Phe Ile Thr Lys Val Phe Arg 
145                 150                 155                 160 


Ser Arg Asp Tyr Gln Pro Leu Leu Trp Ile Phe Gln Gln Leu Phe Arg 
                165                 170                 175     


Arg Val Gln Ala Thr Lys Pro Gln Ala Ser Arg His Glu Ser Ala Glu 
            180                 185                 190         


Ile Phe Val Val Cys Gln Gly Phe Leu Ala Pro Asp Lys Val Asp Ser 
        195                 200                 205             


Lys Phe Phe Asp Pro Lys Phe Ala Phe Lys Glu Val Glu Val Gln Ala 
    210                 215                 220                 


Lys Thr Val Thr Glu Leu Val Thr Lys Lys Lys Pro Lys Ala Glu Gly 
225                 230                 235                 240 


Tyr Ala Glu Gly Asp Leu Thr Leu Tyr His Arg Thr Ser Val Thr Asp 
                245                 250                 255     


Phe Leu Arg Ala Ala Asn Pro Val Asp Phe Leu Ser Lys Ala Ser Glu 
            260                 265                 270         


Ile Met Val Asp Asp Glu Glu Leu Ala Gln His Pro Ala Thr Thr Glu 
        275                 280                 285             


Asp Ile Arg Val Cys Cys Gln Asp Ile Arg Val Leu Gly Arg Lys Glu 
    290                 295                 300                 


Leu Arg Ser Leu Leu Asn Trp Arg Thr Lys Leu Arg Arg Tyr Val Ala 
305                 310                 315                 320 


Lys Lys Leu Lys Glu Gln Ala Lys Ala Leu Asp Ile Ser Leu Ser Ser 
                325                 330                 335     


Gly Glu Glu Asp Glu Gly Asp Glu Glu Asp Ser Thr Ala Gly Thr Thr 
            340                 345                 350         


Lys Gln Pro Ser Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Gln Leu 
        355                 360                 365             


Asn Gln Thr Leu Ala Glu Met Lys Ala Gln Glu Val Ala Glu Leu Lys 
    370                 375                 380                 


Arg Lys Lys Lys Lys Leu Leu Arg Glu Gln Arg Lys Gln Arg Glu Arg 
385                 390                 395                 400 


Val Glu Leu Lys Met Asp Leu Pro Gly Val Ser Ile Ala Asp Glu Gly 
                405                 410                 415     


Glu Thr Gly Met Phe Ser Leu Ser Thr Ile Arg Gly His Gln Leu Leu 
            420                 425                 430         


Glu Glu Val Thr Gln Gly Asp Met Ser Ala Ala Asp Thr Phe Leu Ser 
        435                 440                 445             


Asp Leu Pro Arg Asp Asp Ile Tyr Val Ser Asp Val Glu Asp Asp Gly 
    450                 455                 460                 


Asp Asp Thr Ser Leu Asp Ser Asp Leu Asp Pro Glu Glu Leu Ala Gly 
465                 470                 475                 480 


Val Arg Gly His Gln Gly Leu Arg Asp Gln Lys Arg Met Arg Leu Thr 
                485                 490                 495     


Glu Val Gln Asp Asp Lys Glu Glu Glu Glu Glu Glu Asn Pro Leu Leu 
            500                 505                 510         


Val Pro Leu Glu Glu Lys Ala Val Leu Gln Glu Glu Gln Ala Asn Leu 
        515                 520                 525             


Trp Phe Ser Lys Gly Ser Phe Ala Gly Ile Glu Asp Asp Ala Asp Glu 
    530                 535                 540                 


Ala Leu Glu Ile Ser Gln Ala Gln Leu Leu Phe Glu Asn Arg Arg Lys 
545                 550                 555                 560 


Gly Arg Gln Gln Gln Gln Lys Gln Gln Leu Pro Gln Thr Pro Pro Ser 
                565                 570                 575     


Cys Leu Lys Thr Glu Ile Met Ser Pro Leu Tyr Gln Asp Glu Ala Pro 
            580                 585                 590         


Lys Gly Thr Glu Ala Ser Ser Gly Thr Glu Ala Ala Thr Gly Leu Glu 
        595                 600                 605             


Gly Glu Glu Lys Asp Gly Ile Ser Asp Ser Asp Ser Ser Thr Ser Ser 
    610                 615                 620                 


Glu Glu Glu Glu Ser Trp Glu Pro Leu Arg Gly Lys Lys Arg Ser Arg 
625                 630                 635                 640 


Gly Pro Lys Ser Asp Asp Asp Gly Phe Glu Ile Val Pro Ile Glu Asp 
                645                 650                 655     


Pro Ala Lys His Arg Ile Leu Asp Pro Glu Gly Leu Ala Leu Gly Ala 
            660                 665                 670         


Val Ile Ala Ser Ser Lys Lys Ala Lys Arg Asp Leu Ile Asp Asn Ser 
        675                 680                 685             


Phe Asn Arg Tyr Thr Phe Asn Glu Asp Glu Gly Glu Leu Pro Glu Trp 
    690                 695                 700                 


Phe Val Gln Glu Glu Lys Gln His Arg Ile Arg Gln Leu Pro Val Gly 
705                 710                 715                 720 


Lys Lys Glu Val Glu His Tyr Arg Lys Arg Trp Arg Glu Ile Asn Ala 
                725                 730                 735     


Arg Pro Ile Lys Lys Val Ala Glu Ala Lys Ala Arg Lys Lys Arg Arg 
            740                 745                 750         


Met Leu Lys Arg Leu Glu Gln Thr Arg Lys Lys Ala Glu Ala Val Val 
        755                 760                 765             


Asn Thr Val Asp Ile Ser Glu Arg Glu Lys Val Ala Gln Leu Arg Ser 
    770                 775                 780                 


Leu Tyr Lys Lys Ala Gly Leu Gly Lys Glu Lys Arg His Val Thr Tyr 
785                 790                 795                 800 


Val Val Ala Lys Lys Gly Val Gly Arg Lys Val Arg Arg Pro Ala Gly 
                805                 810                 815     


Val Arg Gly His Phe Lys Val Val Asp Ser Arg Met Lys Lys Asp Gln 
            820                 825                 830         


Arg Ala Gln Gln Arg Lys Glu Gln Lys Lys Lys His Lys Arg Lys 
        835                 840                 845         


<210>  4219
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUBP1__Homo_sapiens__NP_001290362

<400>  4219

Met Ala Asp Tyr Ser Thr Val Pro Pro Pro Ser Ser Gly Ser Ala Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Asn Asp Ala Phe Lys 
            20                  25                  30          


Asp Ala Leu Gln Arg Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp 
        35                  40                  45              


Ala Gly Thr Ser Leu Asn Ser Asn Asp Tyr Gly Tyr Gly Gly Gln Lys 
    50                  55                  60                  


Arg Pro Leu Glu Asp Gly Asp Gly Ser Trp Thr Ser Pro Ser Ser Thr 
65                  70                  75                  80  


Thr His Trp Glu Gly Met Pro Ser Pro Phe Lys Asp Gln Pro Asp Ala 
                85                  90                  95      


Lys Lys Val Ala Pro Gln Asn Asp Ser Phe Gly Thr Gln Leu Pro Pro 
            100                 105                 110         


Met His Gln Gln Gln Ser Arg Ser Val Met Thr Glu Glu Tyr Lys Val 
        115                 120                 125             


Pro Asp Gly Met Val Gly Phe Ile Ile Gly Arg Gly Gly Glu Gln Ile 
    130                 135                 140                 


Ser Arg Ile Gln Gln Glu Ser Gly Cys Lys Ile Gln Ile Ala Pro Asp 
145                 150                 155                 160 


Ser Gly Gly Leu Pro Glu Arg Ser Cys Met Leu Thr Gly Thr Pro Glu 
                165                 170                 175     


Ser Val Gln Ser Ala Lys Arg Leu Leu Asp Gln Ile Val Glu Lys Gly 
            180                 185                 190         


Arg Pro Ala Pro Gly Phe His His Gly Asp Gly Pro Gly Asn Ala Val 
        195                 200                 205             


Gln Glu Ile Met Ile Pro Ala Ser Lys Ala Gly Leu Val Ile Gly Lys 
    210                 215                 220                 


Gly Gly Glu Thr Ile Lys Gln Leu Gln Glu Arg Ala Gly Val Lys Met 
225                 230                 235                 240 


Val Met Ile Gln Asp Gly Pro Gln Asn Thr Gly Ala Asp Lys Pro Leu 
                245                 250                 255     


Arg Ile Thr Gly Asp Pro Tyr Lys Val Gln Gln Ala Lys Glu Met Val 
            260                 265                 270         


Leu Glu Leu Ile Arg Asp Gln Gly Gly Phe Arg Glu Val Arg Asn Glu 
        275                 280                 285             


Tyr Gly Ser Arg Ile Gly Gly Asn Glu Gly Ile Asp Val Pro Ile Pro 
    290                 295                 300                 


Arg Phe Ala Val Gly Ile Val Ile Gly Arg Asn Gly Glu Met Ile Lys 
305                 310                 315                 320 


Lys Ile Gln Asn Asp Ala Gly Val Arg Ile Gln Phe Lys Pro Asp Asp 
                325                 330                 335     


Gly Thr Thr Pro Glu Arg Ile Ala Gln Ile Thr Gly Pro Pro Asp Arg 
            340                 345                 350         


Cys Gln His Ala Ala Glu Ile Ile Thr Asp Leu Leu Arg Ser Val Gln 
        355                 360                 365             


Ala Gly Asn Pro Gly Gly Pro Gly Pro Gly Gly Arg Gly Arg Gly Arg 
    370                 375                 380                 


Gly Gln Gly Asn Trp Asn Met Gly Pro Pro Gly Gly Leu Gln Glu Phe 
385                 390                 395                 400 


Asn Phe Ile Val Pro Thr Gly Lys Thr Gly Leu Ile Ile Gly Lys Gly 
                405                 410                 415     


Gly Glu Thr Ile Lys Ser Ile Ser Gln Gln Ser Gly Ala Arg Ile Glu 
            420                 425                 430         


Leu Gln Arg Asn Pro Pro Pro Asn Ala Asp Pro Asn Met Lys Leu Phe 
        435                 440                 445             


Thr Ile Arg Gly Thr Pro Gln Gln Ile Asp Tyr Ala Arg Gln Leu Ile 
    450                 455                 460                 


Glu Glu Lys Ile Gly Gly Pro Val Asn Pro Leu Gly Pro Pro Val Pro 
465                 470                 475                 480 


His Gly Pro His Gly Val Pro Gly Pro His Gly Pro Pro Gly Pro Pro 
                485                 490                 495     


Gly Pro Gly Thr Pro Met Gly Pro Tyr Asn Pro Ala Pro Tyr Asn Pro 
            500                 505                 510         


Gly Pro Pro Gly Pro Ala Pro His Gly Pro Pro Ala Pro Tyr Ala Pro 
        515                 520                 525             


Gln Gly Trp Gly Asn Ala Tyr Pro His Trp Gln Gln Gln Ala Pro Pro 
    530                 535                 540                 


Asp Pro Ala Lys Ala Gly Thr Asp Pro Asn Ser Ala Ala Trp Ala Ala 
545                 550                 555                 560 


Tyr Tyr Ala His Tyr Tyr Gln Gln Gln Ala Gln Pro Pro Pro Ala Ala 
                565                 570                 575     


Pro Ala Gly Ala Pro Thr Thr Thr Gln Thr Asn Gly Gln Gly Asp Gln 
            580                 585                 590         


Gln Asn Pro Ala Pro Ala Gly Gln Val Asp Tyr Thr Lys Ala Trp Glu 
        595                 600                 605             


Glu Tyr Tyr Lys Lys Met Gly Gln Ala Val Pro Ala Pro Thr Gly Ala 
    610                 615                 620                 


Pro Pro Gly Gly Gln Pro Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr 
625                 630                 635                 640 


Arg Gln Gln Ala Ala Tyr Tyr Ala Gln Thr Ser Pro Gln Gly Met Pro 
                645                 650                 655     


Gln His Pro Pro Ala Pro Gln Gly Gln 
            660                 665 


<210>  4220
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUBP3__Homo_sapiens__NP_003925

<400>  4220

Met Ala Glu Leu Val Gln Gly Gln Ser Ala Pro Val Gly Met Lys Ala 
1               5                   10                  15      


Glu Gly Phe Val Asp Ala Leu His Arg Val Arg Gln Ile Ala Ala Lys 
            20                  25                  30          


Ile Asp Ser Ile Pro His Leu Asn Asn Ser Thr Pro Leu Val Asp Pro 
        35                  40                  45              


Ser Val Tyr Gly Tyr Gly Val Gln Lys Arg Pro Leu Asp Asp Gly Val 
    50                  55                  60                  


Gly Asn Gln Leu Gly Ala Leu Val His Gln Arg Thr Val Ile Thr Glu 
65                  70                  75                  80  


Glu Phe Lys Val Pro Asp Lys Met Val Gly Phe Ile Ile Gly Arg Gly 
                85                  90                  95      


Gly Glu Gln Ile Ser Arg Ile Gln Ala Glu Ser Gly Cys Lys Ile Gln 
            100                 105                 110         


Ile Ala Ser Glu Ser Ser Gly Ile Pro Glu Arg Pro Cys Val Leu Thr 
        115                 120                 125             


Gly Thr Pro Glu Ser Ile Glu Gln Ala Lys Arg Leu Leu Gly Gln Ile 
    130                 135                 140                 


Val Asp Arg Cys Arg Asn Gly Pro Gly Phe His Asn Asp Ile Asp Ser 
145                 150                 155                 160 


Asn Ser Thr Ile Gln Glu Ile Leu Ile Pro Ala Ser Lys Val Gly Leu 
                165                 170                 175     


Val Ile Gly Arg Gly Gly Glu Thr Ile Lys Gln Leu Gln Glu Arg Thr 
            180                 185                 190         


Gly Val Lys Met Val Met Ile Gln Asp Gly Pro Leu Pro Thr Gly Ala 
        195                 200                 205             


Asp Lys Pro Leu Arg Ile Thr Gly Asp Ala Phe Lys Val Gln Gln Ala 
    210                 215                 220                 


Arg Glu Met Val Leu Glu Ile Ile Arg Glu Lys Asp Gln Ala Asp Phe 
225                 230                 235                 240 


Arg Gly Val Arg Gly Asp Phe Asn Ser Arg Met Gly Gly Gly Ser Ile 
                245                 250                 255     


Glu Val Ser Val Pro Arg Phe Ala Val Gly Ile Val Ile Gly Arg Asn 
            260                 265                 270         


Gly Glu Met Ile Lys Lys Ile Gln Asn Asp Ala Gly Val Arg Ile Gln 
        275                 280                 285             


Phe Lys Pro Asp Asp Gly Ile Ser Pro Glu Arg Ala Ala Gln Val Met 
    290                 295                 300                 


Gly Pro Pro Asp Arg Cys Gln His Ala Ala His Ile Ile Ser Glu Leu 
305                 310                 315                 320 


Ile Leu Thr Ala Gln Glu Arg Asp Gly Phe Gly Gly Leu Ala Ala Ala 
                325                 330                 335     


Arg Gly Arg Gly Arg Gly Arg Gly Asp Trp Ser Val Gly Ala Pro Gly 
            340                 345                 350         


Gly Val Gln Glu Ile Thr Tyr Thr Val Pro Ala Asp Lys Cys Gly Leu 
        355                 360                 365             


Val Ile Gly Lys Gly Gly Glu Asn Ile Lys Ser Ile Asn Gln Gln Ser 
    370                 375                 380                 


Gly Ala His Val Glu Leu Gln Arg Asn Pro Pro Pro Asn Ser Asp Pro 
385                 390                 395                 400 


Asn Leu Arg Arg Phe Thr Ile Arg Gly Val Pro Gln Gln Ile Glu Val 
                405                 410                 415     


Ala Arg Gln Leu Ile Asp Glu Lys Val Gly Gly Thr Asn Leu Gly Ala 
            420                 425                 430         


Pro Gly Ala Phe Gly Gln Ser Pro Phe Ser Gln Pro Pro Ala Pro Pro 
        435                 440                 445             


His Gln Asn Thr Phe Pro Pro Arg Ser Ser Gly Cys Phe Pro Asn Met 
    450                 455                 460                 


Ala Ala Lys Val Asn Gly Asn Pro His Ser Thr Pro Val Ser Gly Pro 
465                 470                 475                 480 


Pro Ala Phe Leu Thr Gln Gly Trp Gly Ser Thr Tyr Gln Ala Trp Gln 
                485                 490                 495     


Gln Pro Thr Gln Gln Val Pro Ser Gln Gln Ser Gln Pro Gln Ser Ser 
            500                 505                 510         


Gln Pro Asn Tyr Ser Lys Ala Trp Glu Asp Tyr Tyr Lys Lys Gln Ser 
        515                 520                 525             


His Ala Ala Ser Ala Ala Pro Gln Ala Ser Ser Pro Pro Asp Tyr Thr 
    530                 535                 540                 


Met Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Val Ala Phe Tyr Gly Gln 
545                 550                 555                 560 


Thr Leu Gly Gln Ala Gln Ala His Ser Gln Glu Gln 
                565                 570         


<210>  4221
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUCA1__Homo_sapiens__XP_011539469

<400>  4221

Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro Asp Leu Ile 
1               5                   10                  15      


Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp Asn Ser Thr 
            20                  25                  30          


Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys Asp Glu Val 
        35                  40                  45              


Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His His Gly Gly 
    50                  55                  60                  


Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu Pro Asp His 
65                  70                  75                  80  


Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp Gly Tyr Arg 
                85                  90                  95      


Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu Ile Ile Ser 
            100                 105                 110         


Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu Leu Asn Ile 
        115                 120                 125             


Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln Glu Arg Leu 
    130                 135                 140                 


Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala Ile Tyr Ala 
145                 150                 155                 160 


Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr Ser Val Trp 
                165                 170                 175     


Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu His Trp Pro 
            180                 185                 190         


Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr Ser Thr Thr 
        195                 200                 205             


Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp Ser Thr Asp 
    210                 215                 220                 


Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro Pro Ser Ala 
225                 230                 235                 240 


Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly Val Lys 
                245                 250                 255 


<210>  4222
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUCA2__Homo_sapiens__NP_114409

<400>  4222

Met Arg Pro Gln Glu Leu Pro Arg Leu Ala Phe Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Pro Pro Pro Cys Pro Ala His Ser Ala Thr 
            20                  25                  30          


Arg Phe Asp Pro Thr Trp Glu Ser Leu Asp Ala Arg Gln Leu Pro Ala 
        35                  40                  45              


Trp Phe Asp Gln Ala Lys Phe Gly Ile Phe Ile His Trp Gly Val Phe 
    50                  55                  60                  


Ser Val Pro Ser Phe Gly Ser Glu Trp Phe Trp Trp Tyr Trp Gln Lys 
65                  70                  75                  80  


Glu Lys Ile Pro Lys Tyr Val Glu Phe Met Lys Asp Asn Tyr Pro Pro 
                85                  90                  95      


Ser Phe Lys Tyr Glu Asp Phe Gly Pro Leu Phe Thr Ala Lys Phe Phe 
            100                 105                 110         


Asn Ala Asn Gln Trp Ala Asp Ile Phe Gln Ala Ser Gly Ala Lys Tyr 
        115                 120                 125             


Ile Val Leu Thr Ser Lys His His Glu Gly Phe Thr Leu Trp Gly Ser 
    130                 135                 140                 


Glu Tyr Ser Trp Asn Trp Asn Ala Ile Asp Glu Gly Pro Lys Arg Asp 
145                 150                 155                 160 


Ile Val Lys Glu Leu Glu Val Ala Ile Arg Asn Arg Thr Asp Leu Arg 
                165                 170                 175     


Phe Gly Leu Tyr Tyr Ser Leu Phe Glu Trp Phe His Pro Leu Phe Leu 
            180                 185                 190         


Glu Asp Glu Ser Ser Ser Phe His Lys Arg Gln Phe Pro Val Ser Lys 
        195                 200                 205             


Thr Leu Pro Glu Leu Tyr Glu Leu Val Asn Asn Tyr Gln Pro Glu Val 
    210                 215                 220                 


Leu Trp Ser Asp Gly Asp Gly Gly Ala Pro Asp Gln Tyr Trp Asn Ser 
225                 230                 235                 240 


Thr Gly Phe Leu Ala Trp Leu Tyr Asn Glu Ser Pro Val Arg Gly Thr 
                245                 250                 255     


Val Val Thr Asn Asp Arg Trp Gly Ala Gly Ser Ile Cys Lys His Gly 
            260                 265                 270         


Gly Phe Tyr Thr Cys Ser Asp Arg Tyr Asn Pro Gly His Leu Leu Pro 
        275                 280                 285             


His Lys Trp Glu Asn Cys Met Thr Ile Asp Lys Leu Ser Trp Gly Tyr 
    290                 295                 300                 


Arg Arg Glu Ala Gly Ile Ser Asp Tyr Leu Thr Ile Glu Glu Leu Val 
305                 310                 315                 320 


Lys Gln Leu Val Glu Thr Val Ser Cys Gly Gly Asn Leu Leu Met Asn 
                325                 330                 335     


Ile Gly Pro Thr Leu Asp Gly Thr Ile Ser Val Val Phe Glu Glu Arg 
            340                 345                 350         


Leu Arg Gln Met Gly Ser Trp Leu Lys Val Asn Gly Glu Ala Ile Tyr 
        355                 360                 365             


Glu Thr His Thr Trp Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val 
    370                 375                 380                 


Trp Tyr Thr Ser Lys Pro Lys Glu Lys Leu Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


Lys Trp Pro Thr Ser Gly Gln Leu Phe Leu Gly His Pro Lys Ala Ile 
                405                 410                 415     


Leu Gly Ala Thr Glu Val Lys Leu Leu Gly His Gly Gln Pro Leu Asn 
            420                 425                 430         


Trp Ile Ser Leu Glu Gln Asn Gly Ile Met Val Glu Leu Pro Gln Leu 
        435                 440                 445             


Thr Ile His Gln Met Pro Cys Lys Trp Gly Trp Ala Leu Ala Leu Thr 
    450                 455                 460                 


Asn Val Ile 
465         


<210>  4223
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUNDC1__Homo_sapiens__NP_776155

<400>  4223

Met Ala Thr Arg Asn Pro Pro Pro Gln Asp Tyr Glu Ser Asp Asp Asp 
1               5                   10                  15      


Ser Tyr Glu Val Leu Asp Leu Thr Glu Tyr Ala Arg Arg His Gln Trp 
            20                  25                  30          


Trp Asn Arg Val Phe Gly His Ser Ser Gly Pro Met Val Glu Lys Tyr 
        35                  40                  45              


Ser Val Ala Thr Gln Ile Val Met Gly Gly Val Thr Gly Trp Cys Ala 
    50                  55                  60                  


Gly Phe Leu Phe Gln Lys Val Gly Lys Leu Ala Ala Thr Ala Val Gly 
65                  70                  75                  80  


Gly Gly Phe Leu Leu Leu Gln Ile Ala Ser His Ser Gly Tyr Val Gln 
                85                  90                  95      


Ile Asp Trp Lys Arg Val Glu Lys Asp Val Asn Lys Ala Lys Arg Gln 
            100                 105                 110         


Ile Lys Lys Arg Ala Asn Lys Ala Ala Pro Glu Ile Asn Asn Leu Ile 
        115                 120                 125             


Glu Glu Ala Thr Glu Phe Ile Lys Gln Asn Ile Val Ile Ser Ser Gly 
    130                 135                 140                 


Phe Val Gly Gly Phe Leu Leu Gly Leu Ala Ser 
145                 150                 155 


<210>  4224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUNDC2__Homo_sapiens__NP_076423

<400>  4224

Met Glu Thr Ser Ala Pro Arg Ala Gly Ser Gln Val Val Ala Thr Thr 
1               5                   10                  15      


Ala Arg His Ser Ala Ala Tyr Arg Ala Asp Pro Leu Arg Val Ser Ser 
            20                  25                  30          


Arg Asp Lys Leu Thr Glu Met Ala Ala Ser Ser Gln Gly Asn Phe Glu 
        35                  40                  45              


Gly Asn Phe Glu Ser Leu Asp Leu Ala Glu Phe Ala Lys Lys Gln Pro 
    50                  55                  60                  


Trp Trp Arg Lys Leu Phe Gly Gln Glu Ser Gly Pro Ser Ala Glu Lys 
65                  70                  75                  80  


Tyr Ser Val Ala Thr Gln Leu Phe Ile Gly Gly Val Thr Gly Trp Cys 
                85                  90                  95      


Thr Gly Phe Ile Phe Gln Lys Val Gly Lys Leu Ala Ala Thr Ala Val 
            100                 105                 110         


Gly Gly Gly Phe Phe Leu Leu Gln Leu Ala Asn His Thr Gly Tyr Ile 
        115                 120                 125             


Lys Val Asp Trp Gln Arg Val Glu Lys Asp Met Lys Lys Ala Lys Glu 
    130                 135                 140                 


Gln Leu Lys Ile Arg Lys Ser Asn Gln Ile Pro Thr Glu Val Arg Ser 
145                 150                 155                 160 


Lys Ala Glu Glu Val Val Ser Phe Val Lys Lys Asn Val Leu Val Thr 
                165                 170                 175     


Gly Gly Phe Phe Gly Gly Phe Leu Leu Gly Met Ala Ser 
            180                 185                 


<210>  4225
<211>  794
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FURIN__Homo_sapiens__NP_001276752

<400>  4225

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  4226
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUS__Homo_sapiens__NP_001164408

<400>  4226

Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala 
1               5                   10                  15      


Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro 
            20                  25                  30          


Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser 
        35                  40                  45              


Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Thr 
    50                  55                  60                  


Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly 
65                  70                  75                  80  


Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser 
                85                  90                  95      


Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser 
            100                 105                 110         


Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly 
        115                 120                 125             


Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly 
    130                 135                 140                 


Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln 
145                 150                 155                 160 


Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Asn Tyr Gly Gln Asp 
                165                 170                 175     


Gln Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly Gly Tyr Gly Asn 
            180                 185                 190         


Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr Gly Gln Gln Asp 
        195                 200                 205             


Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly Tyr Glu Pro Arg Gly Arg 
225                 230                 235                 240 


Gly Gly Gly Arg Gly Gly Arg Gly Gly Met Gly Gly Ser Asp Arg Gly 
                245                 250                 255     


Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp Gln Gly Ser Arg His Asp 
            260                 265                 270         


Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr Ile Phe Val Gln Gly Leu 
        275                 280                 285             


Gly Glu Asn Val Thr Ile Glu Ser Val Ala Asp Tyr Phe Lys Gln Ile 
    290                 295                 300                 


Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Gln Pro Met Ile Asn Leu 
305                 310                 315                 320 


Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys Gly Glu Ala Thr Val Ser 
                325                 330                 335     


Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp Trp Phe Asp Gly 
            340                 345                 350         


Lys Glu Phe Ser Gly Asn Pro Ile Lys Val Ser Phe Ala Thr Arg Arg 
        355                 360                 365             


Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly Arg Gly Gly Arg Gly Arg 
    370                 375                 380                 


Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly Gly Gly Gly Gly Gly Gln 
                405                 410                 415     


Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn Pro Thr Cys Glu Asn Met 
            420                 425                 430         


Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln Cys Lys Ala Pro Lys Pro 
        435                 440                 445             


Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser His Met Gly Gly Asn Tyr 
    450                 455                 460                 


Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly Tyr Asp Arg Gly Gly Tyr 
465                 470                 475                 480 


Arg Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly 
                485                 490                 495     


Gly Asp Arg Gly Gly Phe Gly Pro Gly Lys Met Asp Ser Arg Gly Glu 
            500                 505                 510         


His Arg Gln Asp Arg Arg Glu Arg Pro Tyr 
        515                 520         


<210>  4227
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT10__Homo_sapiens__NP_116053

<400>  4227

Met Val Arg Ile Gln Arg Arg Lys Leu Leu Ala Ser Cys Leu Cys Val 
1               5                   10                  15      


Thr Ala Thr Val Phe Leu Leu Val Thr Leu Gln Val Met Val Glu Leu 
            20                  25                  30          


Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser Leu Gln Asp Gly 
        35                  40                  45              


His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn Ser Phe Leu Lys 
    50                  55                  60                  


Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp Glu Leu Asp Ser 
65                  70                  75                  80  


Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly Glu Thr Gly Arg 
                85                  90                  95      


Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr Ile Asn Arg Thr 
            100                 105                 110         


Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe Tyr Gly Thr Asp 
        115                 120                 125             


Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala His His Asp Trp 
    130                 135                 140                 


Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu Phe His 
145                 150                 155                 160 


Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser Arg His 
                165                 170                 175     


Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu Val Leu 
            180                 185                 190         


Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys Leu Arg 
        195                 200                 205             


Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp Pro Pro 
    210                 215                 220                 


Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile Glu Val 
225                 230                 235                 240 


Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln Gln Leu 
                245                 250                 255     


Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile Ile Ala 
            260                 265                 270         


Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp Asp Tyr 
        275                 280                 285             


Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val Pro Val 
    290                 295                 300                 


Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn Lys Ser 
305                 310                 315                 320 


Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala Ser Tyr 
                325                 330                 335     


Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr Val Glu 
            340                 345                 350         


Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr Ala Leu 
        355                 360                 365             


Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn Tyr Ile 
    370                 375                 380                 


Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn Ile Arg 
385                 390                 395                 400 


Leu Gln Glu Lys Gly Leu Pro Pro Lys Arg Trp Glu Ala Glu Asp Thr 
                405                 410                 415     


His Leu Ser Cys Pro Glu Pro Thr Val Phe Ala Phe Ser Pro Leu Arg 
            420                 425                 430         


Thr Pro Pro Leu Ser Ser Leu Arg Glu Met Trp Ile Ser Ser Phe Glu 
        435                 440                 445             


Gln Ser Lys Lys Glu Ala Gln Ala Leu Arg Trp Leu Val Asp Arg Asn 
    450                 455                 460                 


Gln Asn Phe Ser Ser Gln Glu Phe Trp Gly Leu Val Phe Lys Asp 
465                 470                 475                 


<210>  4228
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT11__Homo_sapiens__NP_001271123

<400>  4228

Met Ala Ala Gly Pro Ile Arg Val Val Leu Val Leu Leu Gly Val Leu 
1               5                   10                  15      


Ser Val Cys Ala Ala Ser Gly His Gly Ser Val Ala Glu Arg Glu Ala 
            20                  25                  30          


Gly Gly Glu Ala Glu Trp Ala Glu Pro Trp Asp Gly Ala Val Phe Arg 
        35                  40                  45              


Pro Pro Ser Ala Leu Gly Ala Val Gly Val Thr Arg Ser Ser Gly Thr 
    50                  55                  60                  


Pro Arg Pro Gly Arg Glu Glu Ala Gly Asp Leu Pro Val Leu Leu Trp 
65                  70                  75                  80  


Trp Ser Pro Gly Leu Phe Pro His Phe Pro Gly Asp Ser Glu Arg Ile 
                85                  90                  95      


Glu Cys Ala Arg Gly Ala Cys Val Ala Ser Arg Asn Arg Arg Ala Leu 
            100                 105                 110         


Arg Asp Ser Arg Thr Arg Ala Leu Leu Phe Tyr Gly Thr Asp Phe Arg 
        115                 120                 125             


Ala Ser Ala Ala Pro Leu Pro Arg Leu Ala His Gln Ser Trp Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ser Pro Leu Asn Asn Phe Leu Leu Ser His Gly Pro 
145                 150                 155                 160 


Gly Ile Arg Leu Phe Asn Leu Thr Ser Thr Phe Ser Arg His Ser Asp 
                165                 170                 175     


Tyr Pro Leu Ser Leu Gln Trp Leu Pro Gly Thr Ala Tyr Leu Arg Arg 
            180                 185                 190         


Pro Val Pro Pro Pro Met Glu Arg Ala Glu Trp Arg Arg Arg Gly Tyr 
        195                 200                 205             


Ala Pro Leu Leu Tyr Leu Gln Ser His Cys Asp Val Pro Ala Asp Arg 
    210                 215                 220                 


Asp Arg Tyr Val Arg Glu Leu Met Arg His Ile Pro Val Asp Ser Tyr 
225                 230                 235                 240 


Gly Lys Cys Leu Gln Asn Arg Glu Leu Pro Thr Ala Arg Leu Gln Asp 
                245                 250                 255     


Thr Ala Thr Ala Thr Thr Glu Asp Pro Glu Leu Leu Ala Phe Leu Ser 
            260                 265                 270         


Arg Tyr Lys Phe His Leu Ala Leu Glu Asn Ala Ile Cys Asn Asp Tyr 
        275                 280                 285             


Met Thr Glu Lys Leu Trp Arg Pro Met His Leu Gly Ala Val Pro Val 
    290                 295                 300                 


Tyr Arg Gly Ser Pro Ser Val Arg Asp Trp Met Pro Asn Asn His Ser 
305                 310                 315                 320 


Val Ile Leu Ile Asp Asp Phe Glu Ser Pro Gln Lys Leu Ala Glu Phe 
                325                 330                 335     


Ile Asp Phe Leu Asp Lys Asn Asp Glu Glu Tyr Met Lys Tyr Leu Ala 
            340                 345                 350         


Tyr Lys Gln Pro Gly Gly Ile Thr Asn Gln Phe Leu Leu Asp Ser Leu 
        355                 360                 365             


Lys His Arg Glu Trp Gly Val Asn Asp Pro Leu Leu Pro Asn Tyr Leu 
    370                 375                 380                 


Asn Gly Phe Glu Cys Phe Val Cys Asp Tyr Glu Leu Ala Arg Leu Asp 
385                 390                 395                 400 


Ala Glu Lys Ala His Ala Ala Ser Pro Gly Asp Ser Pro Val Phe Glu 
                405                 410                 415     


Pro His Ile Ala Gln Pro Ser His Met Asp Cys Pro Val Pro Thr Pro 
            420                 425                 430         


Gly Phe Gly Asn Val Glu Glu Ile Pro Glu Asn Asp Ser Ser Leu Val 
        435                 440                 445             


Gln Val Arg Asp His Cys Ile Cys Leu Arg Phe Leu Trp Pro His Ser 
    450                 455                 460                 


Glu Lys Gly Arg Thr His Asn Tyr Ala Ala Val Pro 
465                 470                 475     


<210>  4229
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT1__Homo_sapiens__NP_000139

<400>  4229

Met Trp Leu Arg Ser His Arg Gln Leu Cys Leu Ala Phe Leu Leu Val 
1               5                   10                  15      


Cys Val Leu Ser Val Ile Phe Phe Leu His Ile His Gln Asp Ser Phe 
            20                  25                  30          


Pro His Gly Leu Gly Leu Ser Ile Leu Cys Pro Asp Arg Arg Leu Val 
        35                  40                  45              


Thr Pro Pro Val Ala Ile Phe Cys Leu Pro Gly Thr Ala Met Gly Pro 
    50                  55                  60                  


Asn Ala Ser Ser Ser Cys Pro Gln His Pro Ala Ser Leu Ser Gly Thr 
65                  70                  75                  80  


Trp Thr Val Tyr Pro Asn Gly Arg Phe Gly Asn Gln Met Gly Gln Tyr 
                85                  90                  95      


Ala Thr Leu Leu Ala Leu Ala Gln Leu Asn Gly Arg Arg Ala Phe Ile 
            100                 105                 110         


Leu Pro Ala Met His Ala Ala Leu Ala Pro Val Phe Arg Ile Thr Leu 
        115                 120                 125             


Pro Val Leu Ala Pro Glu Val Asp Ser Arg Thr Pro Trp Arg Glu Leu 
    130                 135                 140                 


Gln Leu His Asp Trp Met Ser Glu Glu Tyr Ala Asp Leu Arg Asp Pro 
145                 150                 155                 160 


Phe Leu Lys Leu Ser Gly Phe Pro Cys Ser Trp Thr Phe Phe His His 
                165                 170                 175     


Leu Arg Glu Gln Ile Arg Arg Glu Phe Thr Leu His Asp His Leu Arg 
            180                 185                 190         


Glu Glu Ala Gln Ser Val Leu Gly Gln Leu Arg Leu Gly Arg Thr Gly 
        195                 200                 205             


Asp Arg Pro Arg Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr 
    210                 215                 220                 


Leu Gln Val Met Pro Gln Arg Trp Lys Gly Val Val Gly Asp Ser Ala 
225                 230                 235                 240 


Tyr Leu Arg Gln Ala Met Asp Trp Phe Arg Ala Arg His Glu Ala Pro 
                245                 250                 255     


Val Phe Val Val Thr Ser Asn Gly Met Glu Trp Cys Lys Glu Asn Ile 
            260                 265                 270         


Asp Thr Ser Gln Gly Asp Val Thr Phe Ala Gly Asp Gly Gln Glu Ala 
        275                 280                 285             


Thr Pro Trp Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile 
    290                 295                 300                 


Met Thr Ile Gly Thr Phe Gly Phe Trp Ala Ala Tyr Leu Ala Gly Gly 
305                 310                 315                 320 


Asp Thr Val Tyr Leu Ala Asn Phe Thr Leu Pro Asp Ser Glu Phe Leu 
                325                 330                 335     


Lys Ile Phe Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Val Gly Ile 
            340                 345                 350         


Asn Ala Asp Leu Ser Pro Leu Trp Thr Leu Ala Lys Pro 
        355                 360                 365 


<210>  4230
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT2__Homo_sapiens__NP_001091107

<400>  4230

Met Leu Val Val Gln Met Pro Phe Ser Phe Pro Met Ala His Phe Ile 
1               5                   10                  15      


Leu Phe Val Phe Thr Val Ser Thr Ile Phe His Val Gln Gln Arg Leu 
            20                  25                  30          


Ala Lys Ile Gln Ala Met Trp Glu Leu Pro Val Gln Ile Pro Val Leu 
        35                  40                  45              


Ala Ser Thr Ser Lys Ala Leu Gly Pro Ser Gln Leu Arg Gly Met Trp 
    50                  55                  60                  


Thr Ile Asn Ala Ile Gly Arg Leu Gly Asn Gln Met Gly Glu Tyr Ala 
65                  70                  75                  80  


Thr Leu Tyr Ala Leu Ala Lys Met Asn Gly Arg Pro Ala Phe Ile Pro 
                85                  90                  95      


Ala Gln Met His Ser Thr Leu Ala Pro Ile Phe Arg Ile Thr Leu Pro 
            100                 105                 110         


Val Leu His Ser Ala Thr Ala Ser Arg Ile Pro Trp Gln Asn Tyr His 
        115                 120                 125             


Leu Asn Asp Trp Met Glu Glu Glu Tyr Arg His Ile Pro Gly Glu Tyr 
    130                 135                 140                 


Val Arg Phe Thr Gly Tyr Pro Cys Ser Trp Thr Phe Tyr His His Leu 
145                 150                 155                 160 


Arg Gln Glu Ile Leu Gln Glu Phe Thr Leu His Asp His Val Arg Glu 
                165                 170                 175     


Glu Ala Gln Lys Phe Leu Arg Gly Leu Gln Val Asn Gly Ser Arg Pro 
            180                 185                 190         


Gly Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr Val His Val 
        195                 200                 205             


Met Pro Lys Val Trp Lys Gly Val Val Ala Asp Arg Arg Tyr Leu Gln 
    210                 215                 220                 


Gln Ala Leu Asp Trp Phe Arg Ala Arg Tyr Ser Ser Leu Ile Phe Val 
225                 230                 235                 240 


Val Thr Ser Asn Gly Met Ala Trp Cys Arg Glu Asn Ile Asp Thr Ser 
                245                 250                 255     


His Gly Asp Val Val Phe Ala Gly Asp Gly Ile Glu Gly Ser Pro Ala 
            260                 265                 270         


Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile Met Thr Ile 
        275                 280                 285             


Gly Thr Phe Gly Ile Trp Ala Ala Tyr Leu Thr Gly Gly Asp Thr Ile 
    290                 295                 300                 


Tyr Leu Ala Asn Tyr Thr Leu Pro Asp Ser Pro Phe Leu Lys Ile Phe 
305                 310                 315                 320 


Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Thr Gly Ile Ala Ala Asp 
                325                 330                 335     


Leu Ser Pro Leu Leu Lys His 
            340             


<210>  4231
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT3__Homo_sapiens__XP_011526169

<400>  4231

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  4232
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT4__Homo_sapiens__NP_002024

<400>  4232

Met Arg Arg Leu Trp Gly Ala Ala Arg Lys Pro Ser Gly Ala Gly Trp 
1               5                   10                  15      


Glu Lys Glu Trp Ala Glu Ala Pro Gln Glu Ala Pro Gly Ala Trp Ser 
            20                  25                  30          


Gly Arg Leu Gly Pro Gly Arg Ser Gly Arg Lys Gly Arg Ala Val Pro 
        35                  40                  45              


Gly Trp Ala Ser Trp Pro Ala His Leu Ala Leu Ala Ala Arg Pro Ala 
    50                  55                  60                  


Arg His Leu Gly Gly Ala Gly Gln Gly Pro Arg Pro Leu His Ser Gly 
65                  70                  75                  80  


Thr Ala Pro Phe His Ser Arg Ala Ser Gly Glu Arg Gln Arg Arg Leu 
                85                  90                  95      


Glu Pro Gln Leu Gln His Glu Ser Arg Cys Arg Ser Ser Thr Pro Ala 
            100                 105                 110         


Asp Ala Trp Arg Ala Glu Ala Ala Leu Pro Val Arg Ala Met Gly Ala 
        115                 120                 125             


Pro Trp Gly Ser Pro Thr Ala Ala Ala Gly Gly Arg Arg Gly Trp Arg 
    130                 135                 140                 


Arg Gly Arg Gly Leu Pro Trp Thr Val Cys Val Leu Ala Ala Ala Gly 
145                 150                 155                 160 


Leu Thr Cys Thr Ala Leu Ile Thr Tyr Ala Cys Trp Gly Gln Leu Pro 
                165                 170                 175     


Pro Leu Pro Trp Ala Ser Pro Thr Pro Ser Arg Pro Val Gly Val Leu 
            180                 185                 190         


Leu Trp Trp Glu Pro Phe Gly Gly Arg Asp Ser Ala Pro Arg Pro Pro 
        195                 200                 205             


Pro Asp Cys Arg Leu Arg Phe Asn Ile Ser Gly Cys Arg Leu Leu Thr 
    210                 215                 220                 


Asp Arg Ala Ser Tyr Gly Glu Ala Gln Ala Val Leu Phe His His Arg 
225                 230                 235                 240 


Asp Leu Val Lys Gly Pro Pro Asp Trp Pro Pro Pro Trp Gly Ile Gln 
                245                 250                 255     


Ala His Thr Ala Glu Glu Val Asp Leu Arg Val Leu Asp Tyr Glu Glu 
            260                 265                 270         


Ala Ala Ala Ala Ala Glu Ala Leu Ala Thr Ser Ser Pro Arg Pro Pro 
        275                 280                 285             


Gly Gln Arg Trp Val Trp Met Asn Phe Glu Ser Pro Ser His Ser Pro 
    290                 295                 300                 


Gly Leu Arg Ser Leu Ala Ser Asn Leu Phe Asn Trp Thr Leu Ser Tyr 
305                 310                 315                 320 


Arg Ala Asp Ser Asp Val Phe Val Pro Tyr Gly Tyr Leu Tyr Pro Arg 
                325                 330                 335     


Ser His Pro Gly Asp Pro Pro Ser Gly Leu Ala Pro Pro Leu Ser Arg 
            340                 345                 350         


Lys Gln Gly Leu Val Ala Trp Val Val Ser His Trp Asp Glu Arg Gln 
        355                 360                 365             


Ala Arg Val Arg Tyr Tyr His Gln Leu Ser Gln His Val Thr Val Asp 
    370                 375                 380                 


Val Phe Gly Arg Gly Gly Pro Gly Gln Pro Val Pro Glu Ile Gly Leu 
385                 390                 395                 400 


Leu His Thr Val Ala Arg Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser 
                405                 410                 415     


Gln His Leu Asp Tyr Ile Thr Glu Lys Leu Trp Arg Asn Ala Leu Leu 
            420                 425                 430         


Ala Gly Ala Val Pro Val Val Leu Gly Pro Asp Arg Ala Asn Tyr Glu 
        435                 440                 445             


Arg Phe Val Pro Arg Gly Ala Phe Ile His Val Asp Asp Phe Pro Ser 
    450                 455                 460                 


Ala Ser Ser Leu Ala Ser Tyr Leu Leu Phe Leu Asp Arg Asn Pro Ala 
465                 470                 475                 480 


Val Tyr Arg Arg Tyr Phe His Trp Arg Arg Ser Tyr Ala Val His Ile 
                485                 490                 495     


Thr Ser Phe Trp Asp Glu Pro Trp Cys Arg Val Cys Gln Ala Val Gln 
            500                 505                 510         


Arg Ala Gly Asp Arg Pro Lys Ser Ile Arg Asn Leu Ala Ser Trp Phe 
        515                 520                 525             


Glu Arg 
    530 


<210>  4233
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT5__Homo_sapiens__NP_002025

<400>  4233

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Leu Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Gly Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Pro Gly 
        35                  40                  45              


Leu Met Ala Val Glu Pro Val Thr Gly Ala Pro Asn Gly Ser Arg Cys 
    50                  55                  60                  


Gln Asp Ser Met Ala Thr Pro Ala His Pro Thr Leu Leu Ile Leu Leu 
65                  70                  75                  80  


Trp Thr Trp Pro Phe Asn Thr Pro Val Ala Leu Pro Arg Cys Ser Glu 
                85                  90                  95      


Met Val Pro Gly Ala Ala Asp Cys Asn Ile Thr Ala Asp Ser Ser Val 
            100                 105                 110         


Tyr Pro Gln Ala Asp Ala Val Ile Val His His Trp Asp Ile Met Tyr 
        115                 120                 125             


Asn Pro Ser Ala Asn Leu Pro Pro Pro Thr Arg Pro Gln Gly Gln Arg 
    130                 135                 140                 


Trp Ile Trp Phe Ser Met Glu Ser Pro Ser Asn Cys Arg His Leu Glu 
145                 150                 155                 160 


Ala Leu Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser Asp Ser 
                165                 170                 175     


Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly Gln Pro 
            180                 185                 190         


Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val Ala Trp 
        195                 200                 205             


Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg Tyr Tyr Gln 
    210                 215                 220                 


Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser His Lys 
225                 230                 235                 240 


Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg Tyr Lys Phe 
                245                 250                 255     


Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr Glu Lys 
            260                 265                 270         


Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val Leu Gly 
        275                 280                 285             


Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala Phe Ile 
    290                 295                 300                 


His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr Leu Gln 
305                 310                 315                 320 


Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe His Trp Arg 
                325                 330                 335     


Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe Cys Lys 
            340                 345                 350         


Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr Val Arg Ser 
        355                 360                 365             


Ile Ala Ala Trp Phe Thr 
    370                 


<210>  4234
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT6__Homo_sapiens__NP_001035791

<400>  4234

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 


<210>  4235
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT7__Homo_sapiens__NP_004470

<400>  4235

Met Asn Asn Ala Gly His Gly Pro Thr Arg Arg Leu Arg Gly Leu Gly 
1               5                   10                  15      


Val Leu Ala Gly Val Ala Leu Leu Ala Ala Leu Trp Leu Leu Trp Leu 
            20                  25                  30          


Leu Gly Ser Ala Pro Arg Gly Thr Pro Ala Pro Gln Pro Thr Ile Thr 
        35                  40                  45              


Ile Leu Val Trp His Trp Pro Phe Thr Asp Gln Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ser Asp Thr Cys Thr Arg Tyr Gly Ile Ala Arg Cys His Leu Ser Ala 
65                  70                  75                  80  


Asn Arg Ser Leu Leu Ala Ser Ala Asp Ala Val Val Phe His His Arg 
                85                  90                  95      


Glu Leu Gln Thr Arg Arg Ser His Leu Pro Leu Ala Gln Arg Pro Arg 
            100                 105                 110         


Gly Gln Pro Trp Val Trp Ala Ser Met Glu Ser Pro Ser His Thr His 
        115                 120                 125             


Gly Leu Ser His Leu Arg Gly Ile Phe Asn Trp Val Leu Ser Tyr Arg 
    130                 135                 140                 


Arg Asp Ser Asp Ile Phe Val Pro Tyr Gly Arg Leu Glu Pro His Trp 
145                 150                 155                 160 


Gly Pro Ser Pro Pro Leu Pro Ala Lys Ser Arg Val Ala Ala Trp Val 
                165                 170                 175     


Val Ser Asn Phe Gln Glu Arg Gln Leu Arg Ala Arg Leu Tyr Arg Gln 
            180                 185                 190         


Leu Ala Pro His Leu Arg Val Asp Val Phe Gly Arg Ala Asn Gly Arg 
        195                 200                 205             


Pro Leu Cys Ala Ser Cys Leu Val Pro Thr Val Ala Gln Tyr Arg Phe 
    210                 215                 220                 


Tyr Leu Ser Phe Glu Asn Ser Gln His Arg Asp Tyr Ile Thr Glu Lys 
225                 230                 235                 240 


Phe Trp Arg Asn Ala Leu Val Ala Gly Thr Val Pro Val Val Leu Gly 
                245                 250                 255     


Pro Pro Arg Ala Thr Tyr Glu Ala Phe Val Pro Ala Asp Ala Phe Val 
            260                 265                 270         


His Val Asp Asp Phe Gly Ser Ala Arg Glu Leu Ala Ala Phe Leu Thr 
        275                 280                 285             


Gly Met Asn Glu Ser Arg Tyr Gln Arg Phe Phe Ala Trp Arg Asp Arg 
    290                 295                 300                 


Leu Arg Val Arg Leu Phe Thr Asp Trp Arg Glu Arg Phe Cys Ala Ile 
305                 310                 315                 320 


Cys Asp Arg Tyr Pro His Leu Pro Arg Ser Gln Val Tyr Glu Asp Leu 
                325                 330                 335     


Glu Gly Trp Phe Gln Ala 
            340         


<210>  4236
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT8__Homo_sapiens__NP_004471

<400>  4236

Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala Gly Asp Trp 
1               5                   10                  15      


Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln Arg Arg Ile 
            20                  25                  30          


Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys Lys Leu Val 
        35                  40                  45              


Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu His His Val 
    50                  55                  60                  


Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr Leu Ile Leu 
65                  70                  75                  80  


Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu Thr Val Phe 
                85                  90                  95      


Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile Ser Thr Gly 
            100                 105                 110         


His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val Val Glu Leu 
        115                 120                 125             


Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu Pro Leu Ala 
    130                 135                 140                 


Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His Gly Asp Pro 
145                 150                 155                 160 


Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile Arg Pro Gln 
                165                 170                 175     


Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys Leu Gly Phe 
            180                 185                 190         


Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp Lys Val Gly 
        195                 200                 205             


Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val His Val Glu 
    210                 215                 220                 


Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp Lys Lys Arg 
225                 230                 235                 240 


Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu Ala Lys Thr 
                245                 250                 255     


Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile Ser Trp Ser 
            260                 265                 270         


Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg Gly Val Ile 
        275                 280                 285             


Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val Cys Thr Phe 
    290                 295                 300                 


Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln Thr Leu His 
305                 310                 315                 320 


Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile Tyr Tyr Phe 
                325                 330                 335     


Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala His Gln Pro 
            340                 345                 350         


Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile Ile Gly Val 
        355                 360                 365             


Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn Arg Lys Leu 
    370                 375                 380                 


Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu Lys Ile Glu 
385                 390                 395                 400 


Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                405                 410         


<210>  4237
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUT9__Homo_sapiens__XP_011533687

<400>  4237

Met Thr Ser Thr Ser Lys Gly Ile Leu Arg Pro Phe Leu Ile Val Cys 
1               5                   10                  15      


Ile Ile Leu Gly Cys Phe Met Ala Cys Leu Leu Ile Tyr Ile Lys Pro 
            20                  25                  30          


Thr Asn Ser Trp Ile Phe Ser Pro Met Glu Ser Ala Ser Ser Val Leu 
        35                  40                  45              


Lys Met Lys Asn Phe Phe Ser Thr Lys Thr Asp Tyr Phe Asn Glu Thr 
    50                  55                  60                  


Thr Ile Leu Val Trp Val Trp Pro Phe Gly Gln Thr Phe Asp Leu Thr 
65                  70                  75                  80  


Ser Cys Gln Ala Met Phe Asn Ile Gln Gly Cys His Leu Thr Thr Asp 
                85                  90                  95      


Arg Ser Leu Tyr Asn Lys Ser His Ala Val Leu Ile His His Arg Asp 
            100                 105                 110         


Ile Ser Trp Asp Leu Thr Asn Leu Pro Gln Gln Ala Arg Pro Pro Phe 
        115                 120                 125             


Gln Lys Trp Ile Trp Met Asn Leu Glu Ser Pro Thr His Thr Pro Gln 
    130                 135                 140                 


Lys Ser Gly Ile Glu His Leu Phe Asn Leu Thr Leu Thr Tyr Arg Arg 
145                 150                 155                 160 


Asp Ser Asp Ile Gln Val Pro Tyr Gly Phe Leu Thr Val Ser Thr Asn 
                165                 170                 175     


Pro Phe Val Phe Glu Val Pro Ser Lys Glu Lys Leu Val Cys Trp Val 
            180                 185                 190         


Val Ser Asn Trp Asn Pro Glu His Ala Arg Val Lys Tyr Tyr Asn Glu 
        195                 200                 205             


Leu Ser Lys Ser Ile Glu Ile His Thr Tyr Gly Gln Ala Phe Gly Glu 
    210                 215                 220                 


Tyr Val Asn Asp Lys Asn Leu Ile Pro Thr Ile Ser Thr Cys Lys Phe 
225                 230                 235                 240 


Tyr Leu Ser Phe Glu Asn Ser Ile His Lys Asp Tyr Ile Thr Glu Lys 
                245                 250                 255     


Leu Tyr Asn Ala Phe Leu Ala Gly Ser Val Pro Val Val Leu Gly Pro 
            260                 265                 270         


Ser Arg Glu Asn Tyr Glu Asn Tyr Ile Pro Ala Asp Ser Phe Ile His 
        275                 280                 285             


Val Glu Asp Tyr Asn Ser Pro Ser Glu Leu Ala Lys Tyr Leu Lys Glu 
    290                 295                 300                 


Val Asp Lys Asn Asn Lys Leu Tyr Leu Ser Tyr Phe Asn Trp Arg Lys 
305                 310                 315                 320 


Asp Phe Thr Val Asn Leu Pro Arg Phe Trp Glu Ser His Ala Cys Leu 
                325                 330                 335     


Ala Cys Asp His Val Lys Arg His Gln Glu Tyr Lys Ser Val Gly Asn 
            340                 345                 350         


Leu Glu Lys Trp Phe Trp Asn 
        355                 


<210>  4238
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUZ__Homo_sapiens__NP_001165408

<400>  4238

Met Gly Glu Glu Gly Thr Gly Gly Thr Val His Leu Leu Cys Leu Ala 
1               5                   10                  15      


Ala Ser Ser Gly Val Pro Leu Phe Cys Arg Ser Ser Arg Gly Gly Ala 
            20                  25                  30          


Pro Ala Arg Gln Gln Leu Pro Phe Ser Val Ile Gly Ser Leu Asn Gly 
        35                  40                  45              


Val His Met Phe Gly Gln Asn Leu Glu Val Gln Leu Ser Ser Ala Arg 
    50                  55                  60                  


Thr Glu Asn Thr Thr Val Val Leu Leu Val Gly Leu Glu Glu Leu Thr 
65                  70                  75                  80  


Asn Ile Arg Asn Val Glu Arg Leu Lys Lys Asp Leu Arg Ala Ser Tyr 
                85                  90                  95      


Cys Leu Ile Asp Ser Phe Leu Gly Asp Ser Glu Leu Ile Gly Asp Leu 
            100                 105                 110         


Thr Gln Cys Val Asp Cys Val Ile Pro Pro Glu Gly Ser Leu Leu Gln 
        115                 120                 125             


Glu Ala Leu Ser Gly Phe Ala Glu Ala Ala Gly Thr Thr Phe Val Ser 
    130                 135                 140                 


Leu Val Val Ser Gly Arg Val Val Ala Ala Thr Glu Gly Trp Trp Arg 
145                 150                 155                 160 


Leu Gly Thr Pro Glu Ala Val Leu Leu Pro Trp Leu Val Gly Ser Leu 
                165                 170                 175     


Pro Pro Gln Thr Ala Arg Asp Tyr Pro Val Tyr Leu Pro His Gly Ser 
            180                 185                 190         


Pro Thr Val Pro His Arg Leu Leu Thr Leu Thr Leu Leu Pro Ser Leu 
        195                 200                 205             


Glu Leu Cys Leu Leu Cys Gly Pro Ser Pro Pro Leu Ser Gln Leu Tyr 
    210                 215                 220                 


Pro Gln Leu Leu Glu Arg Trp Trp Gln Pro Leu Leu Asp Pro Leu Arg 
225                 230                 235                 240 


Ala Cys Leu Pro Leu Gly Pro Arg Ala Leu Pro Ser Gly Phe Pro Leu 
                245                 250                 255     


His Thr Asp Ile Leu Gly Leu Leu Leu Leu His Leu Glu Leu Lys Arg 
            260                 265                 270         


Cys Leu Phe Thr Val Glu Pro Leu Gly Asp Lys Glu Pro Ser Pro Glu 
        275                 280                 285             


Gln Arg Arg Arg Leu Leu Arg Asn Phe Tyr Thr Leu Val Thr Ser Thr 
    290                 295                 300                 


His Phe Pro Pro Glu Pro Gly Pro Pro Glu Lys Thr Glu Asp Glu Val 
305                 310                 315                 320 


Tyr Gln Ala Gln Leu Pro Arg Ala Cys Tyr Leu Val Leu Gly Thr Glu 
                325                 330                 335     


Glu Pro Gly Thr Gly Val Arg Leu Val Ala Leu Gln Leu Gly Leu Arg 
            340                 345                 350         


Arg Leu Leu Leu Leu Leu Ser Pro Gln Ser Pro Thr His Gly Leu Arg 
        355                 360                 365             


Ser Leu Ala Thr His Thr Leu His Ala Leu Thr Pro Leu Leu 
    370                 375                 380         


<210>  4239
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXN__Homo_sapiens__NP_000135

<400>  4239

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  4240
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXR1__Homo_sapiens__NP_001013456

<400>  4240

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr Val Val Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn Glu Val Arg 
        35                  40                  45              


Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu Gly Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu 
            100                 105                 110         


Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys 
        115                 120                 125             


Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu 
    130                 135                 140                 


Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe 
145                 150                 155                 160 


Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala 
                165                 170                 175     


Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile 
            180                 185                 190         


Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His 
        195                 200                 205             


Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp 
                245                 250                 255     


Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly 
305                 310                 315                 320 


Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val 
                325                 330                 335     


Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu 
            340                 345                 350         


Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg 
        355                 360                 365             


Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser 
    370                 375                 380                 


Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly 
385                 390                 395                 400 


Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys 
                405                 410                 415     


Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser 
            420                 425                 430         


Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser 
        435                 440                 445             


Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser 
    450                 455                 460                 


Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu 
465                 470                 475                 480 


Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser 
                485                 490                 495     


His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp 
            500                 505                 510         


Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser 
        515                 520                 525             


Val Asn Glu Asn Gly Leu Gly Lys Arg Cys Asp 
    530                 535                 


<210>  4241
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXR2__Homo_sapiens__NP_004851

<400>  4241

Met Gly Gly Leu Ala Ser Gly Gly Asp Val Glu Pro Gly Leu Pro Val 
1               5                   10                  15      


Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr Lys Gly Phe Val Lys Asp 
            20                  25                  30          


Val His Glu Asp Ser Val Thr Ile Phe Phe Glu Asn Asn Trp Gln Ser 
        35                  40                  45              


Glu Arg Gln Ile Pro Phe Gly Asp Val Arg Leu Pro Pro Pro Ala Asp 
    50                  55                  60                  


Tyr Asn Lys Glu Ile Thr Glu Gly Asp Glu Val Glu Val Tyr Ser Arg 
65                  70                  75                  80  


Ala Asn Glu Gln Glu Pro Cys Gly Trp Trp Leu Ala Arg Val Arg Met 
                85                  90                  95      


Met Lys Gly Asp Phe Tyr Val Ile Glu Tyr Ala Ala Cys Asp Ala Thr 
            100                 105                 110         


Tyr Asn Glu Ile Val Thr Leu Glu Arg Leu Arg Pro Val Asn Pro Asn 
        115                 120                 125             


Pro Leu Ala Thr Lys Gly Ser Phe Phe Lys Val Thr Met Ala Val Pro 
    130                 135                 140                 


Glu Asp Leu Arg Glu Ala Cys Ser Asn Glu Asn Val His Lys Glu Phe 
145                 150                 155                 160 


Lys Lys Ala Leu Gly Ala Asn Cys Ile Phe Leu Asn Ile Thr Asn Ser 
                165                 170                 175     


Glu Leu Phe Ile Leu Ser Thr Thr Glu Ala Pro Val Lys Arg Ala Ser 
            180                 185                 190         


Leu Leu Gly Asp Met His Phe Arg Ser Leu Arg Thr Lys Leu Leu Leu 
        195                 200                 205             


Met Ser Arg Asn Glu Glu Ala Thr Lys His Leu Glu Thr Ser Lys Gln 
    210                 215                 220                 


Leu Ala Ala Ala Phe Gln Glu Glu Phe Thr Val Arg Glu Asp Leu Met 
225                 230                 235                 240 


Gly Leu Ala Ile Gly Thr His Gly Ala Asn Ile Gln Gln Ala Arg Lys 
                245                 250                 255     


Val Pro Gly Val Thr Ala Ile Glu Leu Gly Glu Glu Thr Cys Thr Phe 
            260                 265                 270         


Arg Ile Tyr Gly Glu Thr Pro Glu Ala Cys Arg Gln Ala Arg Ser Tyr 
        275                 280                 285             


Leu Glu Phe Ser Glu Asp Ser Val Gln Val Pro Arg Asn Leu Val Gly 
    290                 295                 300                 


Lys Val Ile Gly Lys Asn Gly Lys Val Ile Gln Glu Ile Val Asp Lys 
305                 310                 315                 320 


Ser Gly Val Val Arg Val Arg Val Glu Gly Asp Asn Asp Lys Lys Asn 
                325                 330                 335     


Pro Arg Glu Glu Gly Met Val Pro Phe Ile Phe Val Gly Thr Arg Glu 
            340                 345                 350         


Asn Ile Ser Asn Ala Gln Ala Leu Leu Glu Tyr His Leu Ser Tyr Leu 
        355                 360                 365             


Gln Glu Val Glu Gln Leu Arg Leu Glu Arg Leu Gln Ile Asp Glu Gln 
    370                 375                 380                 


Leu Arg Gln Ile Gly Leu Gly Phe Arg Pro Pro Gly Ser Gly Arg Gly 
385                 390                 395                 400 


Ser Gly Gly Ser Asp Lys Ala Gly Tyr Ser Thr Asp Glu Ser Ser Ser 
                405                 410                 415     


Ser Ser Leu His Ala Thr Arg Thr Tyr Gly Gly Ser Tyr Gly Gly Arg 
            420                 425                 430         


Gly Arg Gly Arg Arg Thr Gly Gly Pro Ala Tyr Gly Pro Ser Ser Asp 
        435                 440                 445             


Val Ser Thr Ala Ser Glu Thr Glu Ser Glu Lys Arg Glu Glu Pro Asn 
    450                 455                 460                 


Arg Ala Gly Pro Gly Asp Arg Asp Pro Pro Thr Arg Gly Glu Glu Ser 
465                 470                 475                 480 


Arg Arg Arg Pro Thr Gly Gly Arg Gly Arg Gly Pro Pro Pro Ala Pro 
                485                 490                 495     


Arg Pro Thr Ser Arg Tyr Asn Ser Ser Ser Ile Ser Ser Val Leu Lys 
            500                 505                 510         


Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu Asp Thr Ser Glu Pro Glu 
        515                 520                 525             


Pro Pro Val Asp Ser Glu Pro Gly Glu Pro Pro Pro Ala Ser Ala Arg 
    530                 535                 540                 


Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp Glu Asp Arg Thr Val Met 
545                 550                 555                 560 


Asp Gly Gly Leu Glu Ser Asp Gly Pro Asn Met Thr Glu Asn Gly Leu 
                565                 570                 575     


Glu Asp Glu Ser Arg Pro Gln Arg Arg Asn Arg Ser Arg Arg Arg Arg 
            580                 585                 590         


Asn Arg Gly Asn Arg Thr Asp Gly Ser Ile Ser Gly Asp Arg Gln Pro 
        595                 600                 605             


Val Thr Val Ala Asp Tyr Ile Ser Arg Ala Glu Ser Gln Ser Arg Gln 
    610                 615                 620                 


Arg Pro Pro Leu Glu Arg Thr Lys Pro Ser Glu Asp Ser Leu Ser Gly 
625                 630                 635                 640 


Gln Lys Gly Asp Ser Val Ser Lys Leu Pro Lys Gly Pro Ser Glu Asn 
                645                 650                 655     


Gly Glu Leu Ser Ala Pro Leu Glu Leu Gly Ser Met Val Asn Gly Val 
            660                 665                 670         


Ser 
    


<210>  4242
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXYD1__Homo_sapiens__NP_001265647

<400>  4242

Met Ala Ser Leu Gly His Ile Leu Val Phe Cys Val Gly Leu Leu Thr 
1               5                   10                  15      


Met Ala Lys Ala Glu Ser Pro Lys Glu His Asp Pro Phe Thr Tyr Asp 
            20                  25                  30          


Tyr Gln Ser Leu Gln Ile Gly Gly Leu Val Ile Ala Gly Ile Leu Phe 
        35                  40                  45              


Ile Leu Gly Ile Leu Ile Val Leu Ser Arg Arg Cys Arg Cys Lys Phe 
    50                  55                  60                  


Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe 
65                  70                  75                  80  


Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg 
                85                  90          


<210>  4243
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXYD2__Homo_sapiens__NP_001671

<400>  4243

Met Thr Gly Leu Ser Met Asp Gly Gly Gly Ser Pro Lys Gly Asp Val 
1               5                   10                  15      


Asp Pro Phe Tyr Tyr Asp Tyr Glu Thr Val Arg Asn Gly Gly Leu Ile 
            20                  25                  30          


Phe Ala Gly Leu Ala Phe Ile Val Gly Leu Leu Ile Leu Leu Ser Arg 
        35                  40                  45              


Arg Phe Arg Cys Gly Gly Asn Lys Lys Arg Arg Gln Ile Asn Glu Asp 
    50                  55                  60                  


Glu Pro 
65      


<210>  4244
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXYD3__Homo_sapiens__NP_001129479

<400>  4244

Met Gly Arg Gly Tyr Ser Gly Ala Leu Gln Ala Arg Gly Gly Leu Glu 
1               5                   10                  15      


Glu Pro Leu Glu Arg Gly Leu Arg Gly Pro Ser Phe Thr Gln Ser Pro 
            20                  25                  30          


Leu His Gly Ala Ala Ala Ala Tyr Leu Ser Ala Gln Arg Asp Ala Ser 
        35                  40                  45              


Leu Pro Val Pro Gly Gln Arg Ser Asp Met Gln Lys Val Thr Leu Gly 
    50                  55                  60                  


Leu Leu Val Phe Leu Ala Gly Phe Pro Val Leu Asp Ala Asn Asp Leu 
65                  70                  75                  80  


Glu Asp Lys Asn Ser Pro Phe Tyr Tyr Asp Trp His Ser Leu Gln Val 
                85                  90                  95      


Gly Gly Leu Ile Cys Ala Gly Val Leu Cys Ala Met Gly Ile Ile Ile 
            100                 105                 110         


Val Met Ser Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly His 
        115                 120                 125             


His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln Ser 
    130                 135                 140                 


<210>  4245
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXYD5__Homo_sapiens__NP_659003

<400>  4245

Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile 
1               5                   10                  15      


Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser 
            20                  25                  30          


Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp 
        35                  40                  45              


Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro 
    50                  55                  60                  


Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly 
65                  70                  75                  80  


Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys 
                85                  90                  95      


Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser 
            100                 105                 110         


Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly 
        115                 120                 125             


Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys 
    130                 135                 140                 


Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile 
145                 150                 155                 160 


Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn Arg 
                165                 170                 175     


Cys Arg 
        


<210>  4246
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FXYD6__Homo_sapiens__NP_001158303

<400>  4246

Met Glu Leu Val Leu Val Phe Leu Cys Ser Leu Leu Ala Pro Met Val 
1               5                   10                  15      


Leu Ala Ser Ala Ala Glu Lys Glu Lys Glu Met Asp Pro Phe His Tyr 
            20                  25                  30          


Asp Tyr Gln Thr Leu Arg Ile Gly Gly Leu Val Phe Ala Val Val Leu 
        35                  40                  45              


Phe Ser Val Gly Ile Leu Leu Ile Leu Ser Arg Arg Cys Lys Cys Ser 
    50                  55                  60                  


Phe Asn Gln Lys Pro Arg Ala Pro Gly Asp Glu Glu Ala Gln Val Glu 
65                  70                  75                  80  


Asn Leu Ile Thr Ala Asn Ala Thr Glu Pro Gln Lys Ala Glu Asn 
                85                  90                  95  


<210>  4247
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FYB__Homo_sapiens__NP_001230022

<400>  4247

Met Asp Gly Lys Ala Asp Val Lys Ser Leu Met Ala Lys Tyr Asn Thr 
1               5                   10                  15      


Gly Gly Asn Pro Thr Glu Asp Val Ser Val Asn Ser Arg Pro Phe Arg 
            20                  25                  30          


Val Thr Gly Pro Asn Ser Ser Ser Gly Ile Gln Ala Arg Lys Asn Leu 
        35                  40                  45              


Phe Asn Asn Gln Gly Asn Ala Ser Pro Pro Ala Gly Pro Ser Asn Val 
    50                  55                  60                  


Pro Lys Phe Gly Ser Pro Lys Pro Pro Val Ala Val Lys Pro Ser Ser 
65                  70                  75                  80  


Glu Glu Lys Pro Asp Lys Glu Pro Lys Pro Pro Phe Leu Lys Pro Thr 
                85                  90                  95      


Gly Ala Gly Gln Arg Phe Gly Thr Pro Ala Ser Leu Thr Thr Arg Asp 
            100                 105                 110         


Pro Glu Ala Lys Val Gly Phe Leu Lys Pro Val Gly Pro Lys Pro Ile 
        115                 120                 125             


Asn Leu Pro Lys Glu Asp Ser Lys Pro Thr Phe Pro Trp Pro Pro Gly 
    130                 135                 140                 


Asn Lys Pro Ser Leu His Ser Val Asn Gln Asp His Asp Leu Lys Pro 
145                 150                 155                 160 


Leu Gly Pro Lys Ser Gly Pro Thr Pro Pro Thr Ser Glu Asn Glu Gln 
                165                 170                 175     


Lys Gln Ala Phe Pro Lys Leu Thr Gly Val Lys Gly Lys Phe Met Ser 
            180                 185                 190         


Ala Ser Gln Asp Leu Glu Pro Lys Pro Leu Phe Pro Lys Pro Ala Phe 
        195                 200                 205             


Gly Gln Lys Pro Pro Leu Ser Thr Glu Asn Ser His Glu Asp Glu Ser 
    210                 215                 220                 


Pro Met Lys Asn Val Ser Ser Ser Lys Gly Ser Pro Ala Pro Leu Gly 
225                 230                 235                 240 


Val Arg Ser Lys Ser Gly Pro Leu Lys Pro Ala Arg Glu Asp Ser Glu 
                245                 250                 255     


Asn Lys Asp His Ala Gly Glu Ile Ser Ser Leu Pro Phe Pro Gly Val 
            260                 265                 270         


Val Leu Lys Pro Ala Ala Ser Arg Gly Gly Pro Gly Leu Ser Lys Asn 
        275                 280                 285             


Gly Glu Glu Lys Lys Glu Asp Arg Lys Ile Asp Ala Ala Lys Asn Thr 
    290                 295                 300                 


Phe Gln Ser Lys Ile Asn Gln Glu Glu Leu Ala Ser Gly Thr Pro Pro 
305                 310                 315                 320 


Ala Arg Phe Pro Lys Ala Pro Ser Lys Leu Thr Val Gly Gly Pro Trp 
                325                 330                 335     


Gly Gln Ser Gln Glu Lys Glu Lys Gly Asp Lys Asn Ser Ala Thr Pro 
            340                 345                 350         


Lys Gln Lys Pro Leu Pro Pro Leu Phe Thr Leu Gly Pro Pro Pro Pro 
        355                 360                 365             


Lys Pro Asn Arg Pro Pro Asn Val Asp Leu Thr Lys Phe His Lys Thr 
    370                 375                 380                 


Ser Ser Gly Asn Ser Thr Ser Lys Gly Gln Thr Ser Tyr Ser Thr Thr 
385                 390                 395                 400 


Ser Leu Pro Pro Pro Pro Pro Ser His Pro Ala Ser Gln Pro Pro Leu 
                405                 410                 415     


Pro Ala Ser His Pro Ser Gln Pro Pro Val Pro Ser Leu Pro Pro Arg 
            420                 425                 430         


Asn Ile Lys Pro Pro Phe Asp Leu Lys Ser Pro Val Asn Glu Asp Asn 
        435                 440                 445             


Gln Asp Gly Val Thr His Ser Asp Gly Ala Gly Asn Leu Asp Glu Glu 
    450                 455                 460                 


Gln Asp Ser Glu Gly Glu Thr Tyr Glu Asp Ile Glu Ala Ser Lys Glu 
465                 470                 475                 480 


Arg Glu Lys Lys Arg Glu Lys Glu Glu Lys Lys Arg Leu Glu Leu Glu 
                485                 490                 495     


Lys Lys Glu Gln Lys Glu Lys Glu Lys Lys Glu Gln Glu Ile Lys Lys 
            500                 505                 510         


Lys Phe Lys Leu Thr Gly Pro Ile Gln Val Ile His Leu Ala Lys Ala 
        515                 520                 525             


Cys Cys Asp Val Lys Gly Gly Lys Asn Glu Leu Ser Phe Lys Gln Gly 
    530                 535                 540                 


Glu Gln Ile Glu Ile Ile Arg Ile Thr Asp Asn Pro Glu Gly Lys Trp 
545                 550                 555                 560 


Leu Gly Arg Thr Ala Arg Gly Ser Tyr Gly Tyr Ile Lys Thr Thr Ala 
                565                 570                 575     


Val Glu Ile Asp Tyr Asp Ser Leu Lys Leu Lys Lys Asp Ser Leu Gly 
            580                 585                 590         


Ala Pro Ser Arg Pro Ile Glu Asp Asp Gln Glu Val Tyr Asp Asp Val 
        595                 600                 605             


Ala Glu Gln Asp Asp Ile Ser Ser His Ser Gln Ser Gly Ser Gly Gly 
    610                 615                 620                 


Ile Phe Pro Pro Pro Pro Asp Asp Asp Ile Tyr Asp Gly Ile Glu Glu 
625                 630                 635                 640 


Glu Asp Ala Asp Asp Gly Ser Thr Leu Gln Val Gln Glu Lys Ser Asn 
                645                 650                 655     


Thr Trp Ser Trp Gly Ile Leu Lys Met Leu Lys Gly Lys Asp Asp Arg 
            660                 665                 670         


Lys Lys Ser Ile Arg Glu Lys Pro Lys Val Ser Asp Ser Asp Asn Asn 
        675                 680                 685             


Glu Gly Ser Ser Phe Pro Ala Pro Pro Lys Gln Leu Asp Met Gly Asp 
    690                 695                 700                 


Glu Val Tyr Asp Asp Val Asp Thr Ser Asp Phe Pro Val Ser Ser Ala 
705                 710                 715                 720 


Glu Met Ser Gln Gly Thr Asn Val Gly Lys Ala Lys Thr Glu Glu Lys 
                725                 730                 735     


Asp Leu Lys Lys Leu Lys Lys Gln Glu Lys Glu Glu Lys Asp Phe Arg 
            740                 745                 750         


Lys Lys Phe Lys Tyr Asp Gly Glu Ile Arg Val Leu Tyr Ser Thr Lys 
        755                 760                 765             


Val Thr Thr Ser Ile Thr Ser Lys Lys Trp Gly Thr Arg Asp Leu Gln 
    770                 775                 780                 


Val Lys Pro Gly Glu Ser Leu Glu Val Ile Gln Thr Thr Asp Asp Thr 
785                 790                 795                 800 


Lys Val Leu Cys Arg Asn Glu Glu Gly Lys Tyr Gly Tyr Val Leu Arg 
                805                 810                 815     


Ser Tyr Leu Ala Asp Asn Asp Gly Glu Ile Tyr Asp Asp Ile Ala Asp 
            820                 825                 830         


Gly Cys Ile Tyr Asp Asn Asp 
        835                 


<210>  4248
<211>  1478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FYCO1__Homo_sapiens__NP_078789

<400>  4248

Met Ala Ser Thr Asn Ala Glu Ser Gln Leu Gln Arg Ile Ile Arg Asp 
1               5                   10                  15      


Leu Gln Asp Ala Val Thr Glu Leu Ser Lys Glu Phe Gln Glu Ala Gly 
            20                  25                  30          


Glu Pro Ile Thr Asp Asp Ser Thr Ser Leu His Lys Phe Ser Tyr Lys 
        35                  40                  45              


Leu Glu Tyr Leu Leu Gln Phe Asp Gln Lys Glu Lys Ala Thr Leu Leu 
    50                  55                  60                  


Gly Asn Lys Lys Asp Tyr Trp Asp Tyr Phe Cys Ala Cys Leu Ala Lys 
65                  70                  75                  80  


Val Lys Gly Ala Asn Asp Gly Ile Arg Phe Val Lys Ser Ile Ser Glu 
                85                  90                  95      


Leu Arg Thr Ser Leu Gly Lys Gly Arg Ala Phe Ile Arg Tyr Ser Leu 
            100                 105                 110         


Val His Gln Arg Leu Ala Asp Thr Leu Gln Gln Cys Phe Met Asn Thr 
        115                 120                 125             


Lys Val Thr Ser Asp Trp Tyr Tyr Ala Arg Ser Pro Phe Leu Gln Pro 
    130                 135                 140                 


Lys Leu Ser Ser Asp Ile Val Gly Gln Leu Tyr Glu Leu Thr Glu Val 
145                 150                 155                 160 


Gln Phe Asp Leu Ala Ser Arg Gly Phe Asp Leu Asp Ala Ala Trp Pro 
                165                 170                 175     


Thr Phe Ala Arg Arg Thr Leu Thr Thr Gly Ser Ser Ala Tyr Leu Trp 
            180                 185                 190         


Lys Pro Pro Ser Arg Ser Ser Ser Met Ser Ser Leu Val Ser Ser Tyr 
        195                 200                 205             


Leu Gln Thr Gln Glu Met Val Ser Asn Phe Asp Leu Asn Ser Pro Leu 
    210                 215                 220                 


Asn Asn Glu Ala Leu Glu Gly Phe Asp Glu Met Arg Leu Glu Leu Asp 
225                 230                 235                 240 


Gln Leu Glu Val Arg Glu Lys Gln Leu Arg Glu Arg Met Gln Gln Leu 
                245                 250                 255     


Asp Arg Glu Asn Gln Glu Leu Arg Ala Ala Val Ser Gln Gln Gly Glu 
            260                 265                 270         


Gln Leu Gln Thr Glu Arg Glu Arg Gly Arg Thr Ala Ala Glu Asp Asn 
        275                 280                 285             


Val Arg Leu Thr Cys Leu Val Ala Glu Leu Gln Lys Gln Trp Glu Val 
    290                 295                 300                 


Thr Gln Ala Thr Gln Asn Thr Val Lys Glu Leu Gln Thr Cys Leu Gln 
305                 310                 315                 320 


Gly Leu Glu Leu Gly Ala Ala Glu Lys Glu Glu Asp Tyr His Thr Ala 
                325                 330                 335     


Leu Arg Arg Leu Glu Ser Met Leu Gln Pro Leu Ala Gln Glu Leu Glu 
            340                 345                 350         


Ala Thr Arg Asp Ser Leu Asp Lys Lys Asn Gln His Leu Ala Ser Phe 
        355                 360                 365             


Pro Gly Trp Leu Ala Met Ala Gln Gln Lys Ala Asp Thr Ala Ser Asp 
    370                 375                 380                 


Thr Lys Gly Arg Gln Glu Pro Ile Pro Ser Asp Ala Ala Gln Glu Met 
385                 390                 395                 400 


Gln Glu Leu Gly Glu Lys Leu Gln Ala Leu Glu Arg Glu Arg Thr Lys 
                405                 410                 415     


Val Glu Glu Val Asn Arg Gln Gln Ser Ala Gln Leu Glu Gln Leu Val 
            420                 425                 430         


Lys Glu Leu Gln Leu Lys Glu Asp Ala Arg Ala Ser Leu Glu Arg Leu 
        435                 440                 445             


Val Lys Glu Met Ala Pro Leu Gln Glu Glu Leu Ser Gly Lys Gly Gln 
    450                 455                 460                 


Glu Ala Asp Gln Leu Trp Arg Arg Leu Gln Glu Leu Leu Ala His Thr 
465                 470                 475                 480 


Ser Ser Trp Glu Glu Glu Leu Ala Glu Leu Arg Arg Glu Lys Lys Gln 
                485                 490                 495     


Gln Gln Glu Glu Lys Glu Leu Leu Glu Gln Glu Val Arg Ser Leu Thr 
            500                 505                 510         


Arg Gln Leu Gln Phe Leu Glu Thr Gln Leu Ala Gln Val Ser Gln His 
        515                 520                 525             


Val Ser Asp Leu Glu Glu Gln Lys Lys Gln Leu Ile Gln Asp Lys Asp 
    530                 535                 540                 


His Leu Ser Gln Gln Val Gly Met Leu Glu Arg Leu Ala Gly Pro Pro 
545                 550                 555                 560 


Gly Pro Glu Leu Pro Val Ala Gly Glu Lys Asn Glu Ala Leu Val Pro 
                565                 570                 575     


Val Asn Ser Ser Leu Gln Glu Ala Trp Gly Lys Pro Glu Glu Glu Gln 
            580                 585                 590         


Arg Gly Leu Gln Glu Ala Gln Leu Asp Asp Thr Lys Val Gln Glu Gly 
        595                 600                 605             


Ser Gln Glu Glu Glu Leu Arg Gln Ala Asn Arg Glu Leu Glu Lys Glu 
    610                 615                 620                 


Leu Gln Asn Val Val Gly Arg Asn Gln Leu Leu Glu Gly Lys Leu Gln 
625                 630                 635                 640 


Ala Leu Gln Ala Asp Tyr Gln Ala Leu Gln Gln Arg Glu Ser Ala Ile 
                645                 650                 655     


Gln Gly Ser Leu Ala Ser Leu Glu Ala Glu Gln Ala Ser Ile Arg His 
            660                 665                 670         


Leu Gly Asp Gln Met Glu Ala Ser Leu Leu Ala Val Arg Lys Ala Lys 
        675                 680                 685             


Glu Ala Met Lys Ala Gln Met Ala Glu Lys Glu Ala Ile Leu Gln Ser 
    690                 695                 700                 


Lys Glu Gly Glu Cys Gln Gln Leu Arg Glu Glu Val Glu Gln Cys Gln 
705                 710                 715                 720 


Gln Leu Ala Glu Ala Arg His Arg Glu Leu Arg Ala Leu Glu Ser Gln 
                725                 730                 735     


Cys Gln Gln Gln Thr Gln Leu Ile Glu Val Leu Thr Ala Glu Lys Gly 
            740                 745                 750         


Gln Gln Gly Val Gly Pro Pro Thr Asp Asn Glu Ala Arg Glu Leu Ala 
        755                 760                 765             


Ala Gln Leu Ala Leu Ser Gln Ala Gln Leu Glu Val His Gln Gly Glu 
    770                 775                 780                 


Val Gln Arg Leu Gln Ala Gln Val Val Asp Leu Gln Ala Lys Met Arg 
785                 790                 795                 800 


Ala Ala Leu Asp Asp Gln Asp Lys Val Gln Ser Gln Leu Ser Met Ala 
                805                 810                 815     


Glu Ala Val Leu Arg Glu His Lys Thr Leu Val Gln Gln Leu Lys Glu 
            820                 825                 830         


Gln Asn Glu Ala Leu Asn Arg Ala His Val Gln Glu Leu Leu Gln Cys 
        835                 840                 845             


Ser Glu Arg Glu Gly Ala Leu Gln Glu Glu Arg Ala Asp Glu Ala Gln 
    850                 855                 860                 


Gln Arg Glu Glu Glu Leu Arg Ala Leu Gln Glu Glu Leu Ser Gln Ala 
865                 870                 875                 880 


Lys Cys Ser Ser Glu Glu Ala Gln Leu Glu His Ala Glu Leu Gln Glu 
                885                 890                 895     


Gln Leu His Arg Ala Asn Thr Asp Thr Ala Glu Leu Gly Ile Gln Val 
            900                 905                 910         


Cys Ala Leu Thr Val Glu Lys Glu Arg Val Glu Glu Ala Leu Ala Cys 
        915                 920                 925             


Ala Val Gln Glu Leu Gln Asp Ala Lys Glu Ala Ala Ser Arg Glu Arg 
    930                 935                 940                 


Glu Gly Leu Glu Arg Gln Val Ala Gly Leu Gln Gln Glu Lys Glu Ser 
945                 950                 955                 960 


Leu Gln Glu Lys Leu Lys Ala Ala Lys Ala Ala Ala Gly Ser Leu Pro 
                965                 970                 975     


Gly Leu Gln Ala Gln Leu Ala Gln Ala Glu Gln Arg Ala Gln Ser Leu 
            980                 985                 990         


Gln Glu Ala Ala His Gln Glu Leu  Asn Thr Leu Lys Phe  Gln Leu Ser 
        995                 1000                 1005             


Ala Glu  Ile Met Asp Tyr Gln  Ser Arg Leu Lys Asn  Ala Gly Glu 
    1010                 1015                 1020             


Glu Cys  Lys Ser Leu Arg Gly  Gln Leu Glu Glu Gln  Gly Arg Gln 
    1025                 1030                 1035             


Leu Gln  Ala Ala Glu Glu Ala  Val Glu Lys Leu Lys  Ala Thr Gln 
    1040                 1045                 1050             


Ala Asp  Met Gly Glu Lys Leu  Ser Cys Thr Ser Asn  His Leu Ala 
    1055                 1060                 1065             


Glu Cys  Gln Ala Ala Met Leu  Arg Lys Asp Lys Glu  Gly Ala Ala 
    1070                 1075                 1080             


Leu Arg  Glu Asp Leu Glu Arg  Thr Gln Lys Glu Leu  Glu Lys Ala 
    1085                 1090                 1095             


Thr Thr  Lys Ile Gln Glu Tyr  Tyr Asn Lys Leu Cys  Gln Glu Val 
    1100                 1105                 1110             


Thr Asn  Arg Glu Arg Asn Asp  Gln Lys Met Leu Ala  Asp Leu Asp 
    1115                 1120                 1125             


Asp Leu  Asn Arg Thr Lys Lys  Tyr Leu Glu Glu Arg  Leu Ile Glu 
    1130                 1135                 1140             


Leu Leu  Arg Asp Lys Asp Ala  Leu Trp Gln Lys Ser  Asp Ala Leu 
    1145                 1150                 1155             


Glu Phe  Gln Gln Lys Leu Ser  Ala Glu Glu Arg Trp  Leu Gly Asp 
    1160                 1165                 1170             


Thr Glu  Ala Asn His Cys Leu  Asp Cys Lys Arg Glu  Phe Ser Trp 
    1175                 1180                 1185             


Met Val  Arg Arg His His Cys  Arg Ile Cys Gly Arg  Ile Phe Cys 
    1190                 1195                 1200             


Tyr Tyr  Cys Cys Asn Asn Tyr  Val Leu Ser Lys His  Gly Gly Lys 
    1205                 1210                 1215             


Lys Glu  Arg Cys Cys Arg Ala  Cys Phe Gln Lys Leu  Ser Glu Gly 
    1220                 1225                 1230             


Pro Gly  Ser Pro Asp Ser Ser  Gly Ser Gly Thr Ser  Gln Gly Glu 
    1235                 1240                 1245             


Pro Ser  Pro Ala Leu Ser Pro  Ala Ser Pro Gly Pro  Gln Ala Thr 
    1250                 1255                 1260             


Gly Gly  Gln Gly Ala Asn Thr  Asp Tyr Arg Pro Pro  Asp Asp Ala 
    1265                 1270                 1275             


Val Phe  Asp Ile Ile Thr Asp  Glu Glu Leu Cys Gln  Ile Gln Glu 
    1280                 1285                 1290             


Ser Gly  Ser Ser Leu Pro Glu  Thr Pro Thr Glu Thr  Asp Ser Leu 
    1295                 1300                 1305             


Asp Pro  Asn Ala Ala Glu Gln  Asp Thr Thr Ser Thr  Ser Leu Thr 
    1310                 1315                 1320             


Pro Glu  Asp Thr Glu Asp Met  Pro Val Gly Gln Asp  Ser Glu Ile 
    1325                 1330                 1335             


Cys Leu  Leu Lys Ser Gly Glu  Leu Met Ile Lys Val  Pro Leu Thr 
    1340                 1345                 1350             


Val Asp  Glu Ile Ala Ser Phe  Gly Glu Gly Ser Arg  Glu Leu Phe 
    1355                 1360                 1365             


Val Arg  Ser Ser Thr Tyr Ser  Leu Ile Pro Ile Thr  Val Ala Glu 
    1370                 1375                 1380             


Ala Gly  Leu Thr Ile Ser Trp  Val Phe Ser Ser Asp  Pro Lys Ser 
    1385                 1390                 1395             


Ile Ser  Phe Ser Val Val Phe  Gln Glu Ala Glu Asp  Thr Pro Leu 
    1400                 1405                 1410             


Asp Gln  Cys Lys Val Leu Ile  Pro Thr Thr Arg Cys  Asn Ser His 
    1415                 1420                 1425             


Lys Glu  Asn Ile Gln Gly Gln  Leu Lys Val Arg Thr  Pro Gly Ile 
    1430                 1435                 1440             


Tyr Met  Leu Ile Phe Asp Asn  Thr Phe Ser Arg Phe  Val Ser Lys 
    1445                 1450                 1455             


Lys Val  Phe Tyr His Leu Thr  Val Asp Arg Pro Val  Ile Tyr Asp 
    1460                 1465                 1470             


Gly Ser  Asp Phe Leu 
    1475             


<210>  4249
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FYN__Homo_sapiens__NP_002028

<400>  4249

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  4250
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD10__Homo_sapiens__NP_009128

<400>  4250

Met Gln Arg Pro Gly Pro Arg Leu Trp Leu Val Leu Gln Val Met Gly 
1               5                   10                  15      


Ser Cys Ala Ala Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly 
            20                  25                  30          


Lys Cys Gln Pro Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn 
        35                  40                  45              


Met Thr Arg Met Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala 
    50                  55                  60                  


Ala Ile Gln Leu His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His 
65                  70                  75                  80  


Gly His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr 
                85                  90                  95      


Glu Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln 
            100                 105                 110         


Ala Arg Leu Lys Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp 
        115                 120                 125             


Pro Asp Ser Leu Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn 
    130                 135                 140                 


Tyr Leu Cys Met Glu Ala Pro Asn Asn Gly Ser Asp Glu Pro Thr Arg 
145                 150                 155                 160 


Gly Ser Gly Leu Phe Pro Pro Leu Phe Arg Pro Gln Arg Pro His Ser 
                165                 170                 175     


Ala Gln Glu His Pro Leu Lys Asp Gly Gly Pro Gly Arg Gly Gly Cys 
            180                 185                 190         


Asp Asn Pro Gly Lys Phe His His Val Glu Lys Ser Ala Ser Cys Ala 
        195                 200                 205             


Pro Leu Cys Thr Pro Gly Val Asp Val Tyr Trp Ser Arg Glu Asp Lys 
    210                 215                 220                 


Arg Phe Ala Val Val Trp Leu Ala Ile Trp Ala Val Leu Cys Phe Phe 
225                 230                 235                 240 


Ser Ser Ala Phe Thr Val Leu Thr Phe Leu Ile Asp Pro Ala Arg Phe 
                245                 250                 255     


Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met Cys Tyr Cys Val 
            260                 265                 270         


Tyr Ser Val Gly Tyr Leu Ile Arg Leu Phe Ala Gly Ala Glu Ser Ile 
        275                 280                 285             


Ala Cys Asp Arg Asp Ser Gly Gln Leu Tyr Val Ile Gln Glu Gly Leu 
    290                 295                 300                 


Glu Ser Thr Gly Cys Thr Leu Val Phe Leu Val Leu Tyr Tyr Phe Gly 
305                 310                 315                 320 


Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu Thr Trp Phe Leu 
                325                 330                 335     


Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Ser 
            340                 345                 350         


Tyr Phe His Leu Ala Ala Trp Ala Ile Pro Ala Val Lys Thr Ile Leu 
        355                 360                 365             


Ile Leu Val Met Arg Arg Val Ala Gly Asp Glu Leu Thr Gly Val Cys 
    370                 375                 380                 


Tyr Val Gly Ser Met Asp Val Asn Ala Leu Thr Gly Phe Val Leu Ile 
385                 390                 395                 400 


Pro Leu Ala Cys Tyr Leu Val Ile Gly Thr Ser Phe Ile Leu Ser Gly 
                405                 410                 415     


Phe Val Ala Leu Phe His Ile Arg Arg Val Met Lys Thr Gly Gly Glu 
            420                 425                 430         


Asn Thr Asp Lys Leu Glu Lys Leu Met Val Arg Ile Gly Leu Phe Ser 
        435                 440                 445             


Val Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Ala Cys Tyr Phe Tyr 
    450                 455                 460                 


Glu Arg Leu Asn Met Asp Tyr Trp Lys Ile Leu Ala Ala Gln His Lys 
465                 470                 475                 480 


Cys Lys Met Asn Asn Gln Thr Lys Thr Leu Asp Cys Leu Met Ala Ala 
                485                 490                 495     


Ser Ile Pro Ala Val Glu Ile Phe Met Val Lys Ile Phe Met Leu Leu 
            500                 505                 510         


Val Val Gly Ile Thr Ser Gly Met Trp Ile Trp Thr Ser Lys Thr Leu 
        515                 520                 525             


Gln Ser Trp Gln Gln Val Cys Ser Arg Arg Leu Lys Lys Lys Ser Arg 
    530                 535                 540                 


Arg Lys Pro Ala Ser Val Ile Thr Ser Gly Gly Ile Tyr Lys Lys Ala 
545                 550                 555                 560 


Gln His Pro Gln Lys Thr His His Gly Lys Tyr Glu Ile Pro Ala Gln 
                565                 570                 575     


Ser Pro Thr Cys Val 
            580     


<210>  4251
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD1__Homo_sapiens__NP_003496

<400>  4251

Met Ala Glu Glu Glu Ala Pro Lys Lys Ser Arg Ala Ala Gly Gly Gly 
1               5                   10                  15      


Ala Ser Trp Glu Leu Cys Ala Gly Ala Leu Ser Ala Arg Leu Ala Glu 
            20                  25                  30          


Glu Gly Ser Gly Asp Ala Gly Gly Arg Arg Arg Pro Pro Val Asp Pro 
        35                  40                  45              


Arg Arg Leu Ala Arg Gln Leu Leu Leu Leu Leu Trp Leu Leu Glu Ala 
    50                  55                  60                  


Pro Leu Leu Leu Gly Val Arg Ala Gln Ala Ala Gly Gln Gly Pro Gly 
65                  70                  75                  80  


Gln Gly Pro Gly Pro Gly Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln 
                85                  90                  95      


Gln Ser Gly Gln Gln Tyr Asn Gly Glu Arg Gly Ile Ser Val Pro Asp 
            100                 105                 110         


His Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala 
        115                 120                 125             


Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu 
    130                 135                 140                 


Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln 
145                 150                 155                 160 


Cys Ser Ala Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val 
                165                 170                 175     


Cys Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu 
            180                 185                 190         


Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln 
        195                 200                 205             


Trp Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly 
    210                 215                 220                 


Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly Thr Pro Thr Pro 
225                 230                 235                 240 


Ser Leu Leu Pro Glu Phe Trp Thr Ser Asn Pro Gln His Gly Gly Gly 
                245                 250                 255     


Gly His Arg Gly Gly Phe Pro Gly Gly Ala Gly Ala Ser Glu Arg Gly 
            260                 265                 270         


Lys Phe Ser Cys Pro Arg Ala Leu Lys Val Pro Ser Tyr Leu Asn Tyr 
        275                 280                 285             


His Phe Leu Gly Glu Lys Asp Cys Gly Ala Pro Cys Glu Pro Thr Lys 
    290                 295                 300                 


Val Tyr Gly Leu Met Tyr Phe Gly Pro Glu Glu Leu Arg Phe Ser Arg 
305                 310                 315                 320 


Thr Trp Ile Gly Ile Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe 
                325                 330                 335     


Thr Val Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu 
            340                 345                 350         


Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr Ala Val Ala Val Ala 
        355                 360                 365             


Tyr Ile Ala Gly Phe Leu Leu Glu Asp Arg Val Val Cys Asn Asp Lys 
    370                 375                 380                 


Phe Ala Glu Asp Gly Ala Arg Thr Val Ala Gln Gly Thr Lys Lys Glu 
385                 390                 395                 400 


Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe Phe Ser Met Ala Ser 
                405                 410                 415     


Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly 
            420                 425                 430         


Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His 
        435                 440                 445             


Leu Ala Ala Trp Ala Val Pro Ala Ile Lys Thr Ile Thr Ile Leu Ala 
    450                 455                 460                 


Leu Gly Gln Val Asp Gly Asp Val Leu Ser Gly Val Cys Phe Val Gly 
465                 470                 475                 480 


Leu Asn Asn Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe 
                485                 490                 495     


Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser 
            500                 505                 510         


Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu 
        515                 520                 525             


Lys Leu Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr 
    530                 535                 540                 


Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr Phe Tyr Glu Gln Ala 
545                 550                 555                 560 


Phe Arg Asp Gln Trp Glu Arg Ser Trp Val Ala Gln Ser Cys Lys Ser 
                565                 570                 575     


Tyr Ala Ile Pro Cys Pro His Leu Gln Ala Gly Gly Gly Ala Pro Pro 
            580                 585                 590         


His Pro Pro Met Ser Pro Asp Phe Thr Val Phe Met Ile Lys Tyr Leu 
        595                 600                 605             


Met Thr Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly 
    610                 615                 620                 


Lys Thr Leu Asn Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser 
625                 630                 635                 640 


Lys Gln Gly Glu Thr Thr Val 
                645         


<210>  4252
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD2__Homo_sapiens__NP_001457

<400>  4252

Met Arg Pro Arg Ser Ala Leu Pro Arg Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Ala Gly Pro Ala Gln Phe His Gly Glu Lys Gly Ile Ser 
            20                  25                  30          


Ile Pro Asp His Gly Phe Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr 
        35                  40                  45              


Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val 
65                  70                  75                  80  


Lys Val Gln Cys Ser Pro Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr 
                85                  90                  95      


Ala Pro Val Cys Thr Val Leu Glu Gln Ala Ile Pro Pro Cys Arg Ser 
            100                 105                 110         


Ile Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe 
        115                 120                 125             


Gly Phe Gln Trp Pro Glu Arg Leu Arg Cys Glu His Phe Pro Arg His 
    130                 135                 140                 


Gly Ala Glu Gln Ile Cys Val Gly Gln Asn His Ser Glu Asp Gly Ala 
145                 150                 155                 160 


Pro Ala Leu Leu Thr Thr Ala Pro Pro Pro Gly Leu Gln Pro Gly Ala 
                165                 170                 175     


Gly Gly Thr Pro Gly Gly Pro Gly Gly Gly Gly Ala Pro Pro Arg Tyr 
            180                 185                 190         


Ala Thr Leu Glu His Pro Phe His Cys Pro Arg Val Leu Lys Val Pro 
        195                 200                 205             


Ser Tyr Leu Ser Tyr Lys Phe Leu Gly Glu Arg Asp Cys Ala Ala Pro 
    210                 215                 220                 


Cys Glu Pro Ala Arg Pro Asp Gly Ser Met Phe Phe Ser Gln Glu Glu 
225                 230                 235                 240 


Thr Arg Phe Ala Arg Leu Trp Ile Leu Thr Trp Ser Val Leu Cys Cys 
                245                 250                 255     


Ala Ser Thr Phe Phe Thr Val Thr Thr Tyr Leu Val Asp Met Gln Arg 
            260                 265                 270         


Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr 
        275                 280                 285             


Met Val Ser Val Ala Tyr Ile Ala Gly Phe Val Leu Gln Glu Arg Val 
    290                 295                 300                 


Val Cys Asn Glu Arg Phe Ser Glu Asp Gly Tyr Arg Thr Val Val Gln 
305                 310                 315                 320 


Gly Thr Lys Lys Glu Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe 
                325                 330                 335     


Phe Ser Met Ala Ser Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp 
            340                 345                 350         


Phe Leu Ala Ala Gly Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn 
        355                 360                 365             


Ser Gln Tyr Phe His Leu Ala Ala Trp Ala Val Pro Ala Val Lys Thr 
    370                 375                 380                 


Ile Thr Ile Leu Ala Met Gly Gln Ile Asp Gly Asp Leu Leu Ser Gly 
385                 390                 395                 400 


Val Cys Phe Val Gly Leu Asn Ser Leu Asp Pro Leu Arg Gly Phe Val 
                405                 410                 415     


Leu Ala Pro Leu Phe Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu 
            420                 425                 430         


Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp 
        435                 440                 445             


Gly Thr Lys Thr Glu Lys Leu Glu Arg Leu Met Val Arg Ile Gly Val 
    450                 455                 460                 


Phe Ser Val Leu Tyr Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr 
465                 470                 475                 480 


Phe Tyr Glu Gln Ala Phe Arg Glu His Trp Glu Arg Ser Trp Val Ser 
                485                 490                 495     


Gln His Cys Lys Ser Leu Ala Ile Pro Cys Pro Ala His Tyr Thr Pro 
            500                 505                 510         


Arg Met Ser Pro Asp Phe Thr Val Tyr Met Ile Lys Tyr Leu Met Thr 
        515                 520                 525             


Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly Lys Thr 
    530                 535                 540                 


Leu His Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser Arg His 
545                 550                 555                 560 


Gly Glu Thr Thr Val 
                565 


<210>  4253
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD3__Homo_sapiens__NP_665873

<400>  4253

Met Ala Met Thr Trp Ile Val Phe Ser Leu Trp Pro Leu Thr Val Phe 
1               5                   10                  15      


Met Gly His Ile Gly Gly His Ser Leu Phe Ser Cys Glu Pro Ile Thr 
            20                  25                  30          


Leu Arg Met Cys Gln Asp Leu Pro Tyr Asn Thr Thr Phe Met Pro Asn 
        35                  40                  45              


Leu Leu Asn His Tyr Asp Gln Gln Thr Ala Ala Leu Ala Met Glu Pro 
    50                  55                  60                  


Phe His Pro Met Val Asn Leu Asp Cys Ser Arg Asp Phe Arg Pro Phe 
65                  70                  75                  80  


Leu Cys Ala Leu Tyr Ala Pro Ile Cys Met Glu Tyr Gly Arg Val Thr 
                85                  90                  95      


Leu Pro Cys Arg Arg Leu Cys Gln Arg Ala Tyr Ser Glu Cys Ser Lys 
            100                 105                 110         


Leu Met Glu Met Phe Gly Val Pro Trp Pro Glu Asp Met Glu Cys Ser 
        115                 120                 125             


Arg Phe Pro Asp Cys Asp Glu Pro Tyr Pro Arg Leu Val Asp Leu Asn 
    130                 135                 140                 


Leu Ala Gly Glu Pro Thr Glu Gly Ala Pro Val Ala Val Gln Arg Asp 
145                 150                 155                 160 


Tyr Gly Phe Trp Cys Pro Arg Glu Leu Lys Ile Asp Pro Asp Leu Gly 
                165                 170                 175     


Tyr Ser Phe Leu His Val Arg Asp Cys Ser Pro Pro Cys Pro Asn Met 
            180                 185                 190         


Tyr Phe Arg Arg Glu Glu Leu Ser Phe Ala Arg Tyr Phe Ile Gly Leu 
        195                 200                 205             


Ile Ser Ile Ile Cys Leu Ser Ala Thr Leu Phe Thr Phe Leu Thr Phe 
    210                 215                 220                 


Leu Ile Asp Val Thr Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe 
225                 230                 235                 240 


Tyr Ala Val Cys Tyr Met Met Val Ser Leu Ile Phe Phe Ile Gly Phe 
                245                 250                 255     


Leu Leu Glu Asp Arg Val Ala Cys Asn Ala Ser Ile Pro Ala Gln Tyr 
            260                 265                 270         


Lys Ala Ser Thr Val Thr Gln Gly Ser His Asn Lys Ala Cys Thr Met 
        275                 280                 285             


Leu Phe Met Ile Leu Tyr Phe Phe Thr Met Ala Gly Ser Val Trp Trp 
    290                 295                 300                 


Val Ile Leu Thr Ile Thr Trp Phe Leu Ala Ala Val Pro Lys Trp Gly 
305                 310                 315                 320 


Ser Glu Ala Ile Glu Lys Lys Ala Leu Leu Phe His Ala Ser Ala Trp 
                325                 330                 335     


Gly Ile Pro Gly Thr Leu Thr Ile Ile Leu Leu Ala Met Asn Lys Ile 
            340                 345                 350         


Glu Gly Asp Asn Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Val 
        355                 360                 365             


Asp Ala Leu Arg Tyr Phe Val Leu Ala Pro Leu Cys Leu Tyr Val Val 
    370                 375                 380                 


Val Gly Val Ser Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn Arg Val 
385                 390                 395                 400 


Arg Ile Glu Ile Pro Leu Glu Lys Glu Asn Gln Asp Lys Leu Val Lys 
                405                 410                 415     


Phe Met Ile Arg Ile Gly Val Phe Ser Ile Leu Tyr Leu Val Pro Leu 
            420                 425                 430         


Leu Val Val Ile Gly Cys Tyr Phe Tyr Glu Gln Ala Tyr Arg Gly Ile 
        435                 440                 445             


Trp Glu Thr Thr Trp Ile Gln Glu Arg Cys Arg Glu Tyr His Ile Pro 
    450                 455                 460                 


Cys Pro Tyr Gln Val Thr Gln Met Ser Arg Pro Asp Leu Ile Leu Phe 
465                 470                 475                 480 


Leu Met Lys Tyr Leu Met Ala Leu Ile Val Gly Ile Pro Ser Val Phe 
                485                 490                 495     


Trp Val Gly Ser Lys Lys Thr Cys Phe Glu Trp Ala Ser Phe Phe His 
            500                 505                 510         


Gly Arg Arg Lys Lys Glu Ile Val Asn Glu Ser Arg Gln Val Leu Gln 
        515                 520                 525             


Glu Pro Asp Phe Ala Gln Ser Leu Leu Arg Asp Pro Asn Thr Pro Ile 
    530                 535                 540                 


Ile Arg Lys Ser Arg Gly Thr Ser Thr Gln Gly Thr Ser Thr His Ala 
545                 550                 555                 560 


Ser Ser Thr Gln Leu Ala Met Val Asp Asp Gln Arg Ser Lys Ala Gly 
                565                 570                 575     


Ser Ile His Ser Lys Val Ser Ser Tyr His Gly Ser Leu His Arg Ser 
            580                 585                 590         


Arg Asp Gly Arg Tyr Thr Pro Cys Ser Tyr Arg Gly Met Glu Glu Arg 
        595                 600                 605             


Leu Pro His Gly Ser Met Ser Arg Leu Thr Asp His Ser Arg His Ser 
    610                 615                 620                 


Ser Ser His Arg Leu Asn Glu Gln Ser Arg His Ser Ser Ile Arg Asp 
625                 630                 635                 640 


Leu Ser Asn Asn Pro Met Thr His Ile Thr His Gly Thr Ser Met Asn 
                645                 650                 655     


Arg Val Ile Glu Glu Asp Gly Thr Ser Ala 
            660                 665     


<210>  4254
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD4__Homo_sapiens__NP_036325

<400>  4254

Met Ala Trp Arg Gly Ala Gly Pro Ser Val Pro Gly Ala Pro Gly Gly 
1               5                   10                  15      


Val Gly Leu Ser Leu Gly Leu Leu Leu Gln Leu Leu Leu Leu Leu Gly 
            20                  25                  30          


Pro Ala Arg Gly Phe Gly Asp Glu Glu Glu Arg Arg Cys Asp Pro Ile 
        35                  40                  45              


Arg Ile Ser Met Cys Gln Asn Leu Gly Tyr Asn Val Thr Lys Met Pro 
    50                  55                  60                  


Asn Leu Val Gly His Glu Leu Gln Thr Asp Ala Glu Leu Gln Leu Thr 
65                  70                  75                  80  


Thr Phe Thr Pro Leu Ile Gln Tyr Gly Cys Ser Ser Gln Leu Gln Phe 
                85                  90                  95      


Phe Leu Cys Ser Val Tyr Val Pro Met Cys Thr Glu Lys Ile Asn Ile 
            100                 105                 110         


Pro Ile Gly Pro Cys Gly Gly Met Cys Leu Ser Val Lys Arg Arg Cys 
        115                 120                 125             


Glu Pro Val Leu Lys Glu Phe Gly Phe Ala Trp Pro Glu Ser Leu Asn 
    130                 135                 140                 


Cys Ser Lys Phe Pro Pro Gln Asn Asp His Asn His Met Cys Met Glu 
145                 150                 155                 160 


Gly Pro Gly Asp Glu Glu Val Pro Leu Pro His Lys Thr Pro Ile Gln 
                165                 170                 175     


Pro Gly Glu Glu Cys His Ser Val Gly Thr Asn Ser Asp Gln Tyr Ile 
            180                 185                 190         


Trp Val Lys Arg Ser Leu Asn Cys Val Leu Lys Cys Gly Tyr Asp Ala 
        195                 200                 205             


Gly Leu Tyr Ser Arg Ser Ala Lys Glu Phe Thr Asp Ile Trp Met Ala 
    210                 215                 220                 


Val Trp Ala Ser Leu Cys Phe Ile Ser Thr Ala Phe Thr Val Leu Thr 
225                 230                 235                 240 


Phe Leu Ile Asp Ser Ser Arg Phe Ser Tyr Pro Glu Arg Pro Ile Ile 
                245                 250                 255     


Phe Leu Ser Met Cys Tyr Asn Ile Tyr Ser Ile Ala Tyr Ile Val Arg 
            260                 265                 270         


Leu Thr Val Gly Arg Glu Arg Ile Ser Cys Asp Phe Glu Glu Ala Ala 
        275                 280                 285             


Glu Pro Val Leu Ile Gln Glu Gly Leu Lys Asn Thr Gly Cys Ala Ile 
    290                 295                 300                 


Ile Phe Leu Leu Met Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp 
305                 310                 315                 320 


Val Ile Leu Thr Leu Thr Trp Phe Leu Ala Ala Gly Leu Lys Trp Gly 
                325                 330                 335     


His Glu Ala Ile Glu Met His Ser Ser Tyr Phe His Ile Ala Ala Trp 
            340                 345                 350         


Ala Ile Pro Ala Val Lys Thr Ile Val Ile Leu Ile Met Arg Leu Val 
        355                 360                 365             


Asp Ala Asp Glu Leu Thr Gly Leu Cys Tyr Val Gly Asn Gln Asn Leu 
    370                 375                 380                 


Asp Ala Leu Thr Gly Phe Val Val Ala Pro Leu Phe Thr Tyr Leu Val 
385                 390                 395                 400 


Ile Gly Thr Leu Phe Ile Ala Ala Gly Leu Val Ala Leu Phe Lys Ile 
                405                 410                 415     


Arg Ser Asn Leu Gln Lys Asp Gly Thr Lys Thr Asp Lys Leu Glu Arg 
            420                 425                 430         


Leu Met Val Lys Ile Gly Val Phe Ser Val Leu Tyr Thr Val Pro Ala 
        435                 440                 445             


Thr Cys Val Ile Ala Cys Tyr Phe Tyr Glu Ile Ser Asn Trp Ala Leu 
    450                 455                 460                 


Phe Arg Tyr Ser Ala Asp Asp Ser Asn Met Ala Val Glu Met Leu Lys 
465                 470                 475                 480 


Ile Phe Met Ser Leu Leu Val Gly Ile Thr Ser Gly Met Trp Ile Trp 
                485                 490                 495     


Ser Ala Lys Thr Leu His Thr Trp Gln Lys Cys Ser Asn Arg Leu Val 
            500                 505                 510         


Asn Ser Gly Lys Val Lys Arg Glu Lys Arg Gly Asn Gly Trp Val Lys 
        515                 520                 525             


Pro Gly Lys Gly Ser Glu Thr Val Val 
    530                 535         


<210>  4255
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD5__Homo_sapiens__NP_003459

<400>  4255

Met Ala Arg Pro Asp Pro Ser Ala Pro Pro Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Gln Leu Val Gly Arg Ala Ala Ala Ala Ser Lys Ala Pro Val 
            20                  25                  30          


Cys Gln Glu Ile Thr Val Pro Met Cys Arg Gly Ile Gly Tyr Asn Leu 
        35                  40                  45              


Thr His Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu Ala Gly 
    50                  55                  60                  


Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys Ser Pro 
65                  70                  75                  80  


Asp Leu Arg Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys Leu Pro 
                85                  90                  95      


Asp Tyr His Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu Arg Ala 
            100                 105                 110         


Lys Ala Gly Cys Ser Pro Leu Met Arg Gln Tyr Gly Phe Ala Trp Pro 
        115                 120                 125             


Glu Arg Met Ser Cys Asp Arg Leu Pro Val Leu Gly Arg Asp Ala Glu 
    130                 135                 140                 


Val Leu Cys Met Asp Tyr Asn Arg Ser Glu Ala Thr Thr Ala Pro Pro 
145                 150                 155                 160 


Arg Pro Phe Pro Ala Lys Pro Thr Leu Pro Gly Pro Pro Gly Ala Pro 
                165                 170                 175     


Ala Ser Gly Gly Glu Cys Pro Ala Gly Gly Pro Phe Val Cys Lys Cys 
            180                 185                 190         


Arg Glu Pro Phe Val Pro Ile Leu Lys Glu Ser His Pro Leu Tyr Asn 
        195                 200                 205             


Lys Val Arg Thr Gly Gln Val Pro Asn Cys Ala Val Pro Cys Tyr Gln 
    210                 215                 220                 


Pro Ser Phe Ser Ala Asp Glu Arg Thr Phe Ala Thr Phe Trp Ile Gly 
225                 230                 235                 240 


Leu Trp Ser Val Leu Cys Phe Ile Ser Thr Ser Thr Thr Val Ala Thr 
                245                 250                 255     


Phe Leu Ile Asp Met Glu Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile 
            260                 265                 270         


Phe Leu Ser Ala Cys Tyr Leu Cys Val Ser Leu Gly Phe Leu Val Arg 
        275                 280                 285             


Leu Val Val Gly His Ala Ser Val Ala Cys Ser Arg Glu His Asn His 
    290                 295                 300                 


Ile His Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Ile Val Phe Leu 
305                 310                 315                 320 


Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile Leu 
                325                 330                 335     


Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu Ala 
            340                 345                 350         


Ile Ala Gly Tyr Ala Gln Tyr Phe His Leu Ala Ala Trp Leu Ile Pro 
        355                 360                 365             


Ser Val Lys Ser Ile Thr Ala Leu Ala Leu Ser Ser Val Asp Gly Asp 
    370                 375                 380                 


Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Asn Leu Asn Ser Leu 
385                 390                 395                 400 


Arg Gly Phe Val Leu Gly Pro Leu Val Leu Tyr Leu Leu Val Gly Thr 
                405                 410                 415     


Leu Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser Val 
            420                 425                 430         


Ile Lys Gln Gly Gly Thr Lys Thr Asp Lys Leu Glu Lys Leu Met Ile 
        435                 440                 445             


Arg Ile Gly Ile Phe Thr Leu Leu Tyr Thr Val Pro Ala Ser Ile Val 
    450                 455                 460                 


Val Ala Cys Tyr Leu Tyr Glu Gln His Tyr Arg Glu Ser Trp Glu Ala 
465                 470                 475                 480 


Ala Leu Thr Cys Ala Cys Pro Gly His Asp Thr Gly Gln Pro Arg Ala 
                485                 490                 495     


Lys Pro Glu Tyr Trp Val Leu Met Leu Lys Tyr Phe Met Cys Leu Val 
            500                 505                 510         


Val Gly Ile Thr Ser Gly Val Trp Ile Trp Ser Gly Lys Thr Val Glu 
        515                 520                 525             


Ser Trp Arg Arg Phe Thr Ser Arg Cys Cys Cys Arg Pro Arg Arg Gly 
    530                 535                 540                 


His Lys Ser Gly Gly Ala Met Ala Ala Gly Asp Tyr Pro Glu Ala Ser 
545                 550                 555                 560 


Ala Ala Leu Thr Gly Arg Thr Gly Pro Pro Gly Pro Ala Ala Thr Tyr 
                565                 570                 575     


His Lys Gln Val Ser Leu Ser His Val 
            580                 585 


<210>  4256
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD6__Homo_sapiens__NP_001158088

<400>  4256

Met Lys Met Ala Tyr Asn Met Thr Phe Phe Pro Asn Leu Met Gly His 
1               5                   10                  15      


Tyr Asp Gln Ser Ile Ala Ala Val Glu Met Glu His Phe Leu Pro Leu 
            20                  25                  30          


Ala Asn Leu Glu Cys Ser Pro Asn Ile Glu Thr Phe Leu Cys Lys Ala 
        35                  40                  45              


Phe Val Pro Thr Cys Ile Glu Gln Ile His Val Val Pro Pro Cys Arg 
    50                  55                  60                  


Lys Leu Cys Glu Lys Val Tyr Ser Asp Cys Lys Lys Leu Ile Asp Thr 
65                  70                  75                  80  


Phe Gly Ile Arg Trp Pro Glu Glu Leu Glu Cys Asp Arg Leu Gln Tyr 
                85                  90                  95      


Cys Asp Glu Thr Val Pro Val Thr Phe Asp Pro His Thr Glu Phe Leu 
            100                 105                 110         


Gly Pro Gln Lys Lys Thr Glu Gln Val Gln Arg Asp Ile Gly Phe Trp 
        115                 120                 125             


Cys Pro Arg His Leu Lys Thr Ser Gly Gly Gln Gly Tyr Lys Phe Leu 
    130                 135                 140                 


Gly Ile Asp Gln Cys Ala Pro Pro Cys Pro Asn Met Tyr Phe Lys Ser 
145                 150                 155                 160 


Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly Thr Val Ser Ile Phe 
                165                 170                 175     


Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr Phe Leu Ile Asp Val 
            180                 185                 190         


Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Tyr Tyr Ser Val Cys 
        195                 200                 205             


Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly Phe Leu Leu Gly Asp 
    210                 215                 220                 


Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu Glu Leu Gly Asp Thr 
225                 230                 235                 240 


Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr Val Leu Phe Met Leu 
                245                 250                 255     


Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp Trp Val Ile Leu Thr 
            260                 265                 270         


Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp Ser Cys Glu Ala Ile 
        275                 280                 285             


Glu Gln Lys Ala Val Trp Phe His Ala Val Ala Trp Gly Thr Pro Gly 
    290                 295                 300                 


Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys Val Glu Gly Asp Asn 
305                 310                 315                 320 


Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Leu Asp Ala Ser Arg 
                325                 330                 335     


Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val Phe Val Gly Leu Ser 
            340                 345                 350         


Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His Val Arg Gln Val Ile 
        355                 360                 365             


Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys Lys Phe Met Ile Arg 
    370                 375                 380                 


Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro Leu Val Thr Leu Leu 
385                 390                 395                 400 


Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile Thr Trp Glu Ile Thr 
                405                 410                 415     


Trp Val Ser Asp His Cys Arg Gln Tyr His Ile Pro Cys Pro Tyr Gln 
            420                 425                 430         


Ala Lys Ala Lys Ala Arg Pro Glu Leu Ala Leu Phe Met Ile Lys Tyr 
        435                 440                 445             


Leu Met Thr Leu Ile Val Gly Ile Ser Ala Val Phe Trp Val Gly Ser 
    450                 455                 460                 


Lys Lys Thr Cys Thr Glu Trp Ala Gly Phe Phe Lys Arg Asn Arg Lys 
465                 470                 475                 480 


Arg Asp Pro Ile Ser Glu Ser Arg Arg Val Leu Gln Glu Ser Cys Glu 
                485                 490                 495     


Phe Phe Leu Lys His Asn Ser Lys Val Lys His Lys Lys Lys His Tyr 
            500                 505                 510         


Lys Pro Ser Ser His Lys Leu Lys Val Ile Ser Lys Ser Met Gly Thr 
        515                 520                 525             


Ser Thr Gly Ala Thr Ala Asn His Gly Thr Ser Ala Val Ala Ile Thr 
    530                 535                 540                 


Ser His Asp Tyr Leu Gly Gln Glu Thr Leu Thr Glu Ile Gln Thr Ser 
545                 550                 555                 560 


Pro Glu Thr Ser Met Arg Glu Val Lys Ala Asp Gly Ala Ser Thr Pro 
                565                 570                 575     


Arg Leu Arg Glu Gln Asp Cys Gly Glu Pro Ala Ser Pro Ala Ala Ser 
            580                 585                 590         


Ile Ser Arg Leu Ser Gly Glu Gln Val Asp Gly Lys Gly Gln Ala Gly 
        595                 600                 605             


Ser Val Ser Glu Ser Ala Arg Ser Glu Gly Arg Ile Ser Pro Lys Ser 
    610                 615                 620                 


Asp Ile Thr Asp Thr Gly Leu Ala Gln Ser Asn Asn Leu Gln Val Pro 
625                 630                 635                 640 


Ser Ser Ser Glu Pro Ser Ser Leu Lys Gly Ser Thr Ser Leu Leu Val 
                645                 650                 655     


His Pro Val Ser Gly Val Arg Lys Glu Gln Gly Gly Gly Cys His Ser 
            660                 665                 670         


Asp Thr 
        


<210>  4257
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD7__Homo_sapiens__NP_003498

<400>  4257

Met Arg Asp Pro Gly Ala Ala Ala Pro Leu Ser Ser Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Val Leu Ala Leu Leu Gly Ala Leu Ser Ala Gly Ala Gly Ala 
            20                  25                  30          


Gln Pro Tyr His Gly Glu Lys Gly Ile Ser Val Pro Asp His Gly Phe 
        35                  40                  45              


Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
    50                  55                  60                  


Thr Ile Leu Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
65                  70                  75                  80  


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro 
                85                  90                  95      


Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
            100                 105                 110         


Leu Asp Gln Ala Ile Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg 
        115                 120                 125             


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu 
    130                 135                 140                 


Arg Leu Arg Cys Glu Asn Phe Pro Val His Gly Ala Gly Glu Ile Cys 
145                 150                 155                 160 


Val Gly Gln Asn Thr Ser Asp Gly Ser Gly Gly Pro Gly Gly Gly Pro 
                165                 170                 175     


Thr Ala Tyr Pro Thr Ala Pro Tyr Leu Pro Asp Leu Pro Phe Thr Ala 
            180                 185                 190         


Leu Pro Pro Gly Ala Ser Asp Gly Arg Gly Arg Pro Ala Phe Pro Phe 
        195                 200                 205             


Ser Cys Pro Arg Gln Leu Lys Val Pro Pro Tyr Leu Gly Tyr Arg Phe 
    210                 215                 220                 


Leu Gly Glu Arg Asp Cys Gly Ala Pro Cys Glu Pro Gly Arg Ala Asn 
225                 230                 235                 240 


Gly Leu Met Tyr Phe Lys Glu Glu Glu Arg Arg Phe Ala Arg Leu Trp 
                245                 250                 255     


Val Gly Val Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe Thr Val 
            260                 265                 270         


Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu Arg Pro 
        275                 280                 285             


Ile Ile Phe Leu Ser Gly Cys Tyr Phe Met Val Ala Val Ala His Val 
    290                 295                 300                 


Ala Gly Phe Leu Leu Glu Asp Arg Ala Val Cys Val Glu Arg Phe Ser 
305                 310                 315                 320 


Asp Asp Gly Tyr Arg Thr Val Ala Gln Gly Thr Lys Lys Glu Gly Cys 
                325                 330                 335     


Thr Ile Leu Phe Met Val Leu Tyr Phe Phe Gly Met Ala Ser Ser Ile 
            340                 345                 350         


Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys 
        355                 360                 365             


Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His Leu Ala 
    370                 375                 380                 


Ala Trp Ala Val Pro Ala Val Lys Thr Ile Thr Ile Leu Ala Met Gly 
385                 390                 395                 400 


Gln Val Asp Gly Asp Leu Leu Ser Gly Val Cys Tyr Val Gly Leu Ser 
                405                 410                 415     


Ser Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe Val Tyr 
            420                 425                 430         


Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser Leu Phe 
        435                 440                 445             


Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu Lys Leu 
    450                 455                 460                 


Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr Thr Val 
465                 470                 475                 480 


Pro Ala Thr Ile Val Leu Ala Cys Tyr Phe Tyr Glu Gln Ala Phe Arg 
                485                 490                 495     


Glu His Trp Glu Arg Thr Trp Leu Leu Gln Thr Cys Lys Ser Tyr Ala 
            500                 505                 510         


Val Pro Cys Pro Pro Gly His Phe Pro Pro Met Ser Pro Asp Phe Thr 
        515                 520                 525             


Val Phe Met Ile Lys Tyr Leu Met Thr Met Ile Val Gly Ile Thr Thr 
    530                 535                 540                 


Gly Phe Trp Ile Trp Ser Gly Lys Thr Leu Gln Ser Trp Arg Arg Phe 
545                 550                 555                 560 


Tyr His Arg Leu Ser His Ser Ser Lys Gly Glu Thr Ala Val 
                565                 570                 


<210>  4258
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD8__Homo_sapiens__NP_114072

<400>  4258

Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala 
145                 150                 155                 160 


Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro Gly Glu Gln Pro 
                165                 170                 175     


Pro Ser Gly Ser Gly His Gly Arg Pro Pro Gly Ala Arg Pro Pro His 
            180                 185                 190         


Arg Gly Gly Gly Arg Gly Gly Gly Gly Gly Asp Ala Ala Ala Pro Pro 
        195                 200                 205             


Ala Arg Gly Gly Gly Gly Gly Gly Lys Ala Arg Pro Pro Gly Gly Gly 
    210                 215                 220                 


Ala Ala Pro Cys Glu Pro Gly Cys Gln Cys Arg Ala Pro Met Val Ser 
225                 230                 235                 240 


Val Ser Ser Glu Arg His Pro Leu Tyr Asn Arg Val Lys Thr Gly Gln 
                245                 250                 255     


Ile Ala Asn Cys Ala Leu Pro Cys His Asn Pro Phe Phe Ser Gln Asp 
            260                 265                 270         


Glu Arg Ala Phe Thr Val Phe Trp Ile Gly Leu Trp Ser Val Leu Cys 
        275                 280                 285             


Phe Val Ser Thr Phe Ala Thr Val Ser Thr Phe Leu Ile Asp Met Glu 
    290                 295                 300                 


Arg Phe Lys Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Ala Cys Tyr 
305                 310                 315                 320 


Leu Phe Val Ser Val Gly Tyr Leu Val Arg Leu Val Ala Gly His Glu 
                325                 330                 335     


Lys Val Ala Cys Ser Gly Gly Ala Pro Gly Ala Gly Gly Ala Gly Gly 
            340                 345                 350         


Ala Gly Gly Ala Ala Ala Gly Ala Gly Ala Ala Gly Ala Gly Ala Gly 
        355                 360                 365             


Gly Pro Gly Gly Arg Gly Glu Tyr Glu Glu Leu Gly Ala Val Glu Gln 
    370                 375                 380                 


His Val Arg Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Val Val Phe 
385                 390                 395                 400 


Leu Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile 
                405                 410                 415     


Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu 
            420                 425                 430         


Ala Ile Ala Gly Tyr Ser Gln Tyr Phe His Leu Ala Ala Trp Leu Val 
        435                 440                 445             


Pro Ser Val Lys Ser Ile Ala Val Leu Ala Leu Ser Ser Val Asp Gly 
    450                 455                 460                 


Asp Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Ser Leu Asp Asn 
465                 470                 475                 480 


Leu Arg Gly Phe Val Leu Ala Pro Leu Val Ile Tyr Leu Phe Ile Gly 
                485                 490                 495     


Thr Met Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser 
            500                 505                 510         


Val Ile Lys Gln Gln Asp Gly Pro Thr Lys Thr His Lys Leu Glu Lys 
        515                 520                 525             


Leu Met Ile Arg Leu Gly Leu Phe Thr Val Leu Tyr Thr Val Pro Ala 
    530                 535                 540                 


Ala Val Val Val Ala Cys Leu Phe Tyr Glu Gln His Asn Arg Pro Arg 
545                 550                 555                 560 


Trp Glu Ala Thr His Asn Cys Pro Cys Leu Arg Asp Leu Gln Pro Asp 
                565                 570                 575     


Gln Ala Arg Arg Pro Asp Tyr Ala Val Phe Met Leu Lys Tyr Phe Met 
            580                 585                 590         


Cys Leu Val Val Gly Ile Thr Ser Gly Val Trp Val Trp Ser Gly Lys 
        595                 600                 605             


Thr Leu Glu Ser Trp Arg Ser Leu Cys Thr Arg Cys Cys Trp Ala Ser 
    610                 615                 620                 


Lys Gly Ala Ala Val Gly Gly Gly Ala Gly Ala Thr Ala Ala Gly Gly 
625                 630                 635                 640 


Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly 
                645                 650                 655     


Gly Pro Gly Gly Gly Gly Gly Ser Leu Tyr Ser Asp Val Ser Thr Gly 
            660                 665                 670         


Leu Thr Trp Arg Ser Gly Thr Ala Ser Ser Val Ser Tyr Pro Lys Gln 
        675                 680                 685             


Met Pro Leu Ser Gln Val 
    690                 


<210>  4259
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD9__Homo_sapiens__NP_003499

<400>  4259

Met Ala Val Ala Pro Leu Arg Gly Ala Leu Leu Leu Trp Gln Leu Leu 
1               5                   10                  15      


Ala Ala Gly Gly Ala Ala Leu Glu Ile Gly Arg Phe Asp Pro Glu Arg 
            20                  25                  30          


Gly Arg Gly Ala Ala Pro Cys Gln Ala Val Glu Ile Pro Met Cys Arg 
        35                  40                  45              


Gly Ile Gly Tyr Asn Leu Thr Arg Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Ser Gln Gly Glu Ala Ala Ala Glu Leu Ala Glu Phe Ala Pro Leu Val 
65                  70                  75                  80  


Gln Tyr Gly Cys His Ser His Leu Arg Phe Phe Leu Cys Ser Leu Tyr 
                85                  90                  95      


Ala Pro Met Cys Thr Asp Gln Val Ser Thr Pro Ile Pro Ala Cys Arg 
            100                 105                 110         


Pro Met Cys Glu Gln Ala Arg Leu Arg Cys Ala Pro Ile Met Glu Gln 
        115                 120                 125             


Phe Asn Phe Gly Trp Pro Asp Ser Leu Asp Cys Ala Arg Leu Pro Thr 
    130                 135                 140                 


Arg Asn Asp Pro His Ala Leu Cys Met Glu Ala Pro Glu Asn Ala Thr 
145                 150                 155                 160 


Ala Gly Pro Ala Glu Pro His Lys Gly Leu Gly Met Leu Pro Val Ala 
                165                 170                 175     


Pro Arg Pro Ala Arg Pro Pro Gly Asp Leu Gly Pro Gly Ala Gly Gly 
            180                 185                 190         


Ser Gly Thr Cys Glu Asn Pro Glu Lys Phe Gln Tyr Val Glu Lys Ser 
        195                 200                 205             


Arg Ser Cys Ala Pro Arg Cys Gly Pro Gly Val Glu Val Phe Trp Ser 
    210                 215                 220                 


Arg Arg Asp Lys Asp Phe Ala Leu Val Trp Met Ala Val Trp Ser Ala 
225                 230                 235                 240 


Leu Cys Phe Phe Ser Thr Ala Phe Thr Val Leu Thr Phe Leu Leu Glu 
                245                 250                 255     


Pro His Arg Phe Gln Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met 
            260                 265                 270         


Cys Tyr Asn Val Tyr Ser Leu Ala Phe Leu Ile Arg Ala Val Ala Gly 
        275                 280                 285             


Ala Gln Ser Val Ala Cys Asp Gln Glu Ala Gly Ala Leu Tyr Val Ile 
    290                 295                 300                 


Gln Glu Gly Leu Glu Asn Thr Gly Cys Thr Leu Val Phe Leu Leu Leu 
305                 310                 315                 320 


Tyr Tyr Phe Gly Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu 
                325                 330                 335     


Thr Trp Phe Leu Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu 
            340                 345                 350         


Ala His Gly Ser Tyr Phe His Met Ala Ala Trp Gly Leu Pro Ala Leu 
        355                 360                 365             


Lys Thr Ile Val Ile Leu Thr Leu Arg Lys Val Ala Gly Asp Glu Leu 
    370                 375                 380                 


Thr Gly Leu Cys Tyr Val Ala Ser Thr Asp Ala Ala Ala Leu Thr Gly 
385                 390                 395                 400 


Phe Val Leu Val Pro Leu Ser Gly Tyr Leu Val Leu Gly Ser Ser Phe 
                405                 410                 415     


Leu Leu Thr Gly Phe Val Ala Leu Phe His Ile Arg Lys Ile Met Lys 
            420                 425                 430         


Thr Gly Gly Thr Asn Thr Glu Lys Leu Glu Lys Leu Met Val Lys Ile 
        435                 440                 445             


Gly Val Phe Ser Ile Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Val 
    450                 455                 460                 


Cys Tyr Val Tyr Glu Arg Leu Asn Met Asp Phe Trp Arg Leu Arg Ala 
465                 470                 475                 480 


Thr Glu Gln Pro Cys Ala Ala Ala Ala Gly Pro Gly Gly Arg Arg Asp 
                485                 490                 495     


Cys Ser Leu Pro Gly Gly Ser Val Pro Thr Val Ala Val Phe Met Leu 
            500                 505                 510         


Lys Ile Phe Met Ser Leu Val Val Gly Ile Thr Ser Gly Val Trp Val 
        515                 520                 525             


Trp Ser Ser Lys Thr Phe Gln Thr Trp Gln Ser Leu Cys Tyr Arg Lys 
    530                 535                 540                 


Ile Ala Ala Gly Arg Ala Arg Ala Lys Ala Cys Arg Ala Pro Gly Ser 
545                 550                 555                 560 


Tyr Gly Arg Gly Thr His Cys His Tyr Lys Ala Pro Thr Val Val Leu 
                565                 570                 575     


His Met Thr Lys Thr Asp Pro Ser Leu Glu Asn Pro Thr His Leu 
            580                 585                 590     


<210>  4260
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZR1__Homo_sapiens__NP_001129669

<400>  4260

Met Asp Gln Asp Tyr Glu Arg Arg Leu Leu Arg Gln Ile Val Ile Gln 
1               5                   10                  15      


Asn Glu Asn Thr Met Pro Arg Val Thr Glu Met Arg Arg Thr Leu Thr 
            20                  25                  30          


Pro Ala Ser Ser Pro Val Ser Ser Pro Ser Lys His Gly Asp Arg Phe 
        35                  40                  45              


Ile Pro Ser Arg Ala Gly Ala Asn Trp Ser Val Asn Phe His Arg Ile 
    50                  55                  60                  


Asn Glu Asn Glu Lys Ser Pro Ser Gln Asn Arg Lys Ala Lys Asp Ala 
65                  70                  75                  80  


Thr Ser Asp Asn Gly Lys Asp Gly Leu Ala Tyr Ser Ala Leu Leu Lys 
                85                  90                  95      


Asn Glu Leu Leu Gly Ala Gly Ile Glu Lys Val Gln Asp Pro Gln Thr 
            100                 105                 110         


Glu Asp Arg Arg Leu Gln Pro Ser Thr Pro Glu Lys Lys Gly Leu Phe 
        115                 120                 125             


Thr Val Thr Arg Leu Cys Asp Leu Ser Val Glu Gly Asp Ser Val Thr 
    130                 135                 140                 


Ser Val Gly Trp Ser Glu Arg Gly Asn Leu Val Ala Val Gly Thr His 
145                 150                 155                 160 


Lys Gly Phe Val Gln Ile Trp Asp Ala Ala Ala Gly Lys Lys Leu Ser 
                165                 170                 175     


Met Leu Glu Gly His Thr Ala Arg Val Gly Ala Leu Ala Trp Asn Ala 
            180                 185                 190         


Glu Gln Leu Ser Ser Gly Ser Arg Asp Arg Met Ile Leu Gln Arg Asp 
        195                 200                 205             


Ile Arg Thr Pro Pro Leu Gln Ser Glu Arg Arg Leu Gln Gly His Arg 
    210                 215                 220                 


Gln Glu Val Cys Gly Leu Lys Trp Ser Thr Asp His Gln Leu Leu Ala 
225                 230                 235                 240 


Ser Gly Gly Asn Asp Asn Lys Leu Leu Val Trp Asn His Ser Ser Leu 
                245                 250                 255     


Ser Pro Val Gln Gln Tyr Thr Glu His Leu Ala Ala Val Lys Ala Ile 
            260                 265                 270         


Ala Trp Ser Pro His Gln His Gly Leu Leu Ala Ser Gly Gly Gly Thr 
        275                 280                 285             


Ala Asp Arg Cys Ile Arg Phe Trp Asn Thr Leu Thr Gly Gln Pro Leu 
    290                 295                 300                 


Gln Cys Ile Asp Thr Gly Ser Gln Val Cys Asn Leu Ala Trp Ser Lys 
305                 310                 315                 320 


His Ala Asn Glu Leu Val Ser Thr His Gly Tyr Ser Gln Asn Gln Ile 
                325                 330                 335     


Leu Val Trp Lys Tyr Pro Ser Leu Thr Gln Val Ala Lys Leu Thr Gly 
            340                 345                 350         


His Ser Tyr Arg Val Leu Tyr Leu Ala Met Ser Pro Asp Gly Glu Ala 
        355                 360                 365             


Ile Val Thr Gly Ala Gly Asp Glu Thr Leu Arg Phe Trp Asn Val Phe 
    370                 375                 380                 


Ser Lys Thr Arg Ser Thr Lys Glu Ser Val Ser Val Leu Asn Leu Phe 
385                 390                 395                 400 


Thr Arg Ile Arg 
                


<210>  4261
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G0S2__Homo_sapiens__NP_056529

<400>  4261

Met Glu Thr Val Gln Glu Leu Ile Pro Leu Ala Lys Glu Met Met Ala 
1               5                   10                  15      


Gln Lys Arg Lys Gly Lys Met Val Lys Leu Tyr Val Leu Gly Ser Val 
            20                  25                  30          


Leu Ala Leu Phe Gly Val Val Leu Gly Leu Met Glu Thr Val Cys Ser 
        35                  40                  45              


Pro Phe Thr Ala Ala Arg Arg Leu Arg Asp Gln Glu Ala Ala Val Ala 
    50                  55                  60                  


Glu Leu Gln Ala Ala Leu Glu Arg Gln Ala Leu Gln Lys Gln Ala Leu 
65                  70                  75                  80  


Gln Glu Lys Gly Lys Gln Gln Asp Thr Val Leu Gly Gly Arg Ala Leu 
                85                  90                  95      


Ser Asn Arg Gln His Ala Ser 
            100             


<210>  4262
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G2E3__Homo_sapiens__NP_060239

<400>  4262

Met Asn Glu Ser Lys Pro Gly Asp Ser Gln Asn Leu Ala Cys Val Phe 
1               5                   10                  15      


Cys Arg Lys His Asp Asp Cys Pro Asn Lys Tyr Gly Glu Lys Lys Thr 
            20                  25                  30          


Lys Glu Lys Trp Asn Leu Thr Val His Tyr Tyr Cys Leu Leu Met Ser 
        35                  40                  45              


Ser Gly Ile Trp Gln Arg Gly Lys Glu Glu Glu Gly Val Tyr Gly Phe 
    50                  55                  60                  


Leu Ile Glu Asp Ile Arg Lys Glu Val Asn Arg Ala Ser Lys Leu Lys 
65                  70                  75                  80  


Cys Cys Val Cys Lys Lys Asn Gly Ala Ser Ile Gly Cys Val Ala Pro 
                85                  90                  95      


Arg Cys Lys Arg Ser Tyr His Phe Pro Cys Gly Leu Gln Arg Glu Cys 
            100                 105                 110         


Ile Phe Gln Phe Thr Gly Asn Phe Ala Ser Phe Cys Trp Asp His Arg 
        115                 120                 125             


Pro Val Gln Ile Ile Thr Ser Asn Asn Tyr Arg Glu Ser Leu Pro Cys 
    130                 135                 140                 


Thr Ile Cys Leu Glu Phe Ile Glu Pro Ile Pro Ser Tyr Asn Ile Leu 
145                 150                 155                 160 


Arg Ser Pro Cys Cys Lys Asn Ala Trp Phe His Arg Asp Cys Leu Gln 
                165                 170                 175     


Val Gln Ala Ile Asn Ala Gly Val Phe Phe Phe Arg Cys Thr Ile Cys 
            180                 185                 190         


Asn Asn Ser Asp Ile Phe Gln Lys Glu Met Leu Arg Met Gly Ile His 
        195                 200                 205             


Ile Pro Glu Lys Asp Ala Ser Trp Glu Leu Glu Glu Asn Ala Tyr Gln 
    210                 215                 220                 


Glu Leu Leu Gln His Tyr Glu Arg Cys Asp Val Arg Arg Cys Arg Cys 
225                 230                 235                 240 


Lys Glu Gly Arg Asp Tyr Asn Ala Pro Asp Ser Lys Trp Glu Ile Lys 
                245                 250                 255     


Arg Cys Gln Cys Cys Gly Ser Ser Gly Thr His Leu Ala Cys Ser Ser 
            260                 265                 270         


Leu Arg Ser Trp Glu Gln Asn Trp Glu Cys Leu Glu Cys Arg Gly Ile 
        275                 280                 285             


Ile Tyr Asn Ser Gly Glu Phe Gln Lys Ala Lys Lys His Val Leu Pro 
    290                 295                 300                 


Asn Ser Asn Asn Val Gly Ile Thr Asp Cys Leu Leu Glu Glu Ser Ser 
305                 310                 315                 320 


Pro Lys Leu Pro Arg Gln Ser Pro Gly Ser Gln Ser Lys Asp Leu Leu 
                325                 330                 335     


Arg Gln Gly Ser Lys Phe Arg Arg Asn Val Ser Thr Leu Leu Ile Glu 
            340                 345                 350         


Leu Gly Phe Gln Ile Lys Lys Lys Thr Lys Arg Leu Tyr Ile Asn Lys 
        355                 360                 365             


Ala Asn Ile Trp Asn Ser Ala Leu Asp Ala Phe Arg Asn Arg Asn Phe 
    370                 375                 380                 


Asn Pro Ser Tyr Ala Ile Glu Val Ala Tyr Val Ile Glu Asn Asp Asn 
385                 390                 395                 400 


Phe Gly Ser Glu His Pro Gly Ser Lys Gln Glu Phe Leu Ser Leu Leu 
                405                 410                 415     


Met Gln His Leu Glu Asn Ser Ser Leu Phe Glu Gly Ser Leu Ser Lys 
            420                 425                 430         


Asn Leu Ser Leu Asn Ser Gln Ala Leu Lys Glu Asn Leu Tyr Tyr Glu 
        435                 440                 445             


Ala Gly Lys Met Leu Ala Ile Ser Leu Val His Gly Gly Pro Ser Pro 
    450                 455                 460                 


Gly Phe Phe Ser Lys Thr Leu Phe Asn Cys Leu Val Tyr Gly Pro Glu 
465                 470                 475                 480 


Asn Thr Gln Pro Ile Leu Asp Asp Val Ser Asp Phe Asp Val Ala Gln 
                485                 490                 495     


Ile Ile Ile Arg Ile Asn Thr Ala Thr Thr Val Ala Asp Leu Lys Ser 
            500                 505                 510         


Ile Ile Asn Glu Cys Tyr Asn Tyr Leu Glu Leu Ile Gly Cys Leu Arg 
        515                 520                 525             


Leu Ile Thr Thr Leu Ser Asp Lys Tyr Met Leu Val Lys Asp Ile Leu 
    530                 535                 540                 


Gly Tyr His Val Ile Gln Arg Val His Thr Pro Phe Glu Ser Phe Lys 
545                 550                 555                 560 


Gln Gly Leu Lys Thr Leu Gly Val Leu Glu Lys Ile Gln Ala Tyr Pro 
                565                 570                 575     


Glu Ala Phe Cys Ser Ile Leu Cys His Lys Pro Glu Ser Leu Ser Ala 
            580                 585                 590         


Lys Ile Leu Ser Glu Leu Phe Thr Val His Thr Leu Pro Asp Val Lys 
        595                 600                 605             


Ala Leu Gly Phe Trp Asn Ser Tyr Leu Gln Ala Val Glu Asp Gly Lys 
    610                 615                 620                 


Ser Thr Thr Thr Met Glu Asp Ile Leu Ile Phe Ala Thr Gly Cys Ser 
625                 630                 635                 640 


Ser Ile Pro Pro Ala Gly Phe Lys Pro Thr Pro Ser Ile Glu Cys Leu 
                645                 650                 655     


His Val Asp Phe Pro Val Gly Asn Lys Cys Asn Asn Cys Leu Ala Ile 
            660                 665                 670         


Pro Ile Thr Asn Thr Tyr Lys Glu Phe Gln Glu Asn Met Asp Phe Thr 
        675                 680                 685             


Ile Arg Asn Thr Leu Arg Leu Glu Lys Glu Glu Ser Ser His Tyr Ile 
    690                 695                 700                 


Gly His 
705     


<210>  4263
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G3BP1__Homo_sapiens__XP_006714813

<400>  4263

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln 
465     


<210>  4264
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6PC2__Homo_sapiens__NP_001075155

<400>  4264

Met Asp Phe Leu His Arg Asn Gly Val Leu Ile Ile Gln His Leu Gln 
1               5                   10                  15      


Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val 
            20                  25                  30          


Gly Asp Pro Arg Asn Ile Phe Phe Ile Tyr Phe Pro Leu Cys Phe Gln 
        35                  40                  45              


Phe Asn Gln Thr Val Gly Thr Lys Met Ile Trp Val Ala Val Ile Gly 
    50                  55                  60                  


Asp Trp Leu Asn Leu Ile Phe Lys Trp Ile Leu Phe Gly His Arg Pro 
65                  70                  75                  80  


Tyr Trp Trp Val Gln Glu Thr Gln Ile Tyr Pro Asn His Ser Ser Pro 
                85                  90                  95      


Cys Leu Glu Gln Phe Pro Thr Thr Cys Glu Thr Gly Pro Gly Ser Pro 
            100                 105                 110         


Ser Gly His Ala Met Gly Ala Ser Cys Val Trp Tyr Val Met Val Thr 
        115                 120                 125             


Ala Ala Leu Ser His Thr Val Cys Gly Met Asp Lys Phe Ser Ile Thr 
    130                 135                 140                 


Leu His Arg His Ala Gly Gly Arg Gly Leu 
145                 150                 


<210>  4265
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6PC3__Homo_sapiens__NP_612396

<400>  4265

Met Glu Ser Thr Leu Gly Ala Gly Ile Val Ile Ala Glu Ala Leu Gln 
1               5                   10                  15      


Asn Gln Leu Ala Trp Leu Glu Asn Val Trp Leu Trp Ile Thr Phe Leu 
            20                  25                  30          


Gly Asp Pro Lys Ile Leu Phe Leu Phe Tyr Phe Pro Ala Ala Tyr Tyr 
        35                  40                  45              


Ala Ser Arg Arg Val Gly Ile Ala Val Leu Trp Ile Ser Leu Ile Thr 
    50                  55                  60                  


Glu Trp Leu Asn Leu Ile Phe Lys Trp Phe Leu Phe Gly Asp Arg Pro 
65                  70                  75                  80  


Phe Trp Trp Val His Glu Ser Gly Tyr Tyr Ser Gln Ala Pro Ala Gln 
                85                  90                  95      


Val His Gln Phe Pro Ser Ser Cys Glu Thr Gly Pro Gly Ser Pro Ser 
            100                 105                 110         


Gly His Cys Met Ile Thr Gly Ala Ala Leu Trp Pro Ile Met Thr Ala 
        115                 120                 125             


Leu Ser Ser Gln Val Ala Thr Arg Ala Arg Ser Arg Trp Val Arg Val 
    130                 135                 140                 


Met Pro Ser Leu Ala Tyr Cys Thr Phe Leu Leu Ala Val Gly Leu Ser 
145                 150                 155                 160 


Arg Ile Phe Ile Leu Ala His Phe Pro His Gln Val Leu Ala Gly Leu 
                165                 170                 175     


Ile Thr Gly Ala Val Leu Gly Trp Leu Met Thr Pro Arg Val Pro Met 
            180                 185                 190         


Glu Arg Glu Leu Ser Phe Tyr Gly Leu Thr Ala Leu Ala Leu Met Leu 
        195                 200                 205             


Gly Thr Ser Leu Ile Tyr Trp Thr Leu Phe Thr Leu Gly Leu Asp Leu 
    210                 215                 220                 


Ser Trp Ser Ile Ser Leu Ala Phe Lys Trp Cys Glu Arg Pro Glu Trp 
225                 230                 235                 240 


Ile His Val Asp Ser Arg Pro Phe Ala Ser Leu Ser Arg Asp Ser Gly 
                245                 250                 255     


Ala Ala Leu Gly Leu Gly Ile Ala Leu His Ser Pro Cys Tyr Ala Gln 
            260                 265                 270         


Val Arg Arg Ala Gln Leu Gly Asn Gly Gln Lys Ile Ala Cys Leu Val 
        275                 280                 285             


Leu Ala Met Gly Leu Leu Gly Pro Leu Asp Trp Leu Gly His Pro Pro 
    290                 295                 300                 


Gln Ile Ser Leu Phe Tyr Ile Phe Asn Phe Leu Lys Tyr Thr Leu Trp 
305                 310                 315                 320 


Pro Cys Leu Val Leu Ala Leu Val Pro Trp Ala Val His Met Phe Ser 
                325                 330                 335     


Ala Gln Glu Ala Pro Pro Ile His Ser Ser 
            340                 345     


<210>  4266
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6PC__Homo_sapiens__NP_000142

<400>  4266

Met Glu Glu Gly Met Asn Val Leu His Asp Phe Gly Ile Gln Ser Thr 
1               5                   10                  15      


His Tyr Leu Gln Val Asn Tyr Gln Asp Ser Gln Asp Trp Phe Ile Leu 
            20                  25                  30          


Val Ser Val Ile Ala Asp Leu Arg Asn Ala Phe Tyr Val Leu Phe Pro 
        35                  40                  45              


Ile Trp Phe His Leu Gln Glu Ala Val Gly Ile Lys Leu Leu Trp Val 
    50                  55                  60                  


Ala Val Ile Gly Asp Trp Leu Asn Leu Val Phe Lys Trp Ile Leu Phe 
65                  70                  75                  80  


Gly Gln Arg Pro Tyr Trp Trp Val Leu Asp Thr Asp Tyr Tyr Ser Asn 
                85                  90                  95      


Thr Ser Val Pro Leu Ile Lys Gln Phe Pro Val Thr Cys Glu Thr Gly 
            100                 105                 110         


Pro Gly Ser Pro Ser Gly His Ala Met Gly Thr Ala Gly Val Tyr Tyr 
        115                 120                 125             


Val Met Val Thr Ser Thr Leu Ser Ile Phe Gln Gly Lys Ile Lys Pro 
    130                 135                 140                 


Thr Tyr Arg Phe Arg Cys Leu Asn Val Ile Leu Trp Leu Gly Phe Trp 
145                 150                 155                 160 


Ala Val Gln Leu Asn Val Cys Leu Ser Arg Ile Tyr Leu Ala Ala His 
                165                 170                 175     


Phe Pro His Gln Val Val Ala Gly Val Leu Ser Gly Ile Ala Val Ala 
            180                 185                 190         


Glu Thr Phe Ser His Ile His Ser Ile Tyr Asn Ala Ser Leu Lys Lys 
        195                 200                 205             


Tyr Phe Leu Ile Thr Phe Phe Leu Phe Ser Phe Ala Ile Gly Phe Tyr 
    210                 215                 220                 


Leu Leu Leu Lys Gly Leu Gly Val Asp Leu Leu Trp Thr Leu Glu Lys 
225                 230                 235                 240 


Ala Gln Arg Trp Cys Glu Gln Pro Glu Trp Val His Ile Asp Thr Thr 
                245                 250                 255     


Pro Phe Ala Ser Leu Leu Lys Asn Leu Gly Thr Leu Phe Gly Leu Gly 
            260                 265                 270         


Leu Ala Leu Asn Ser Ser Met Tyr Arg Glu Ser Cys Lys Gly Lys Leu 
        275                 280                 285             


Ser Lys Trp Leu Pro Phe Arg Leu Ser Ser Ile Val Ala Ser Leu Val 
    290                 295                 300                 


Leu Leu His Val Phe Asp Ser Leu Lys Pro Pro Ser Gln Val Glu Leu 
305                 310                 315                 320 


Val Phe Tyr Val Leu Ser Phe Cys Lys Ser Ala Val Val Pro Leu Ala 
                325                 330                 335     


Ser Val Ser Val Ile Pro Tyr Cys Leu Ala Gln Val Leu Gly Gln Pro 
            340                 345                 350         


His Lys Lys Ser Leu 
        355         


<210>  4267
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6PD__Homo_sapiens__NP_000393

<400>  4267

Met Gly Arg Arg Gly Ser Ala Pro Gly Asn Gly Arg Thr Leu Arg Gly 
1               5                   10                  15      


Cys Glu Arg Gly Gly Arg Arg Arg Arg Ser Ala Asp Ser Val Met Ala 
            20                  25                  30          


Glu Gln Val Ala Leu Ser Arg Thr Gln Val Cys Gly Ile Leu Arg Glu 
        35                  40                  45              


Glu Leu Phe Gln Gly Asp Ala Phe His Gln Ser Asp Thr His Ile Phe 
    50                  55                  60                  


Ile Ile Met Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Ile Tyr Pro 
65                  70                  75                  80  


Thr Ile Trp Trp Leu Phe Arg Asp Gly Leu Leu Pro Glu Asn Thr Phe 
                85                  90                  95      


Ile Val Gly Tyr Ala Arg Ser Arg Leu Thr Val Ala Asp Ile Arg Lys 
            100                 105                 110         


Gln Ser Glu Pro Phe Phe Lys Ala Thr Pro Glu Glu Lys Leu Lys Leu 
        115                 120                 125             


Glu Asp Phe Phe Ala Arg Asn Ser Tyr Val Ala Gly Gln Tyr Asp Asp 
    130                 135                 140                 


Ala Ala Ser Tyr Gln Arg Leu Asn Ser His Met Asn Ala Leu His Leu 
145                 150                 155                 160 


Gly Ser Gln Ala Asn Arg Leu Phe Tyr Leu Ala Leu Pro Pro Thr Val 
                165                 170                 175     


Tyr Glu Ala Val Thr Lys Asn Ile His Glu Ser Cys Met Ser Gln Ile 
            180                 185                 190         


Gly Trp Asn Arg Ile Ile Val Glu Lys Pro Phe Gly Arg Asp Leu Gln 
        195                 200                 205             


Ser Ser Asp Arg Leu Ser Asn His Ile Ser Ser Leu Phe Arg Glu Asp 
    210                 215                 220                 


Gln Ile Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Met Val Gln Asn 
225                 230                 235                 240 


Leu Met Val Leu Arg Phe Ala Asn Arg Ile Phe Gly Pro Ile Trp Asn 
                245                 250                 255     


Arg Asp Asn Ile Ala Cys Val Ile Leu Thr Phe Lys Glu Pro Phe Gly 
            260                 265                 270         


Thr Glu Gly Arg Gly Gly Tyr Phe Asp Glu Phe Gly Ile Ile Arg Asp 
        275                 280                 285             


Val Met Gln Asn His Leu Leu Gln Met Leu Cys Leu Val Ala Met Glu 
    290                 295                 300                 


Lys Pro Ala Ser Thr Asn Ser Asp Asp Val Arg Asp Glu Lys Val Lys 
305                 310                 315                 320 


Val Leu Lys Cys Ile Ser Glu Val Gln Ala Asn Asn Val Val Leu Gly 
                325                 330                 335     


Gln Tyr Val Gly Asn Pro Asp Gly Glu Gly Glu Ala Thr Lys Gly Tyr 
            340                 345                 350         


Leu Asp Asp Pro Thr Val Pro Arg Gly Ser Thr Thr Ala Thr Phe Ala 
        355                 360                 365             


Ala Val Val Leu Tyr Val Glu Asn Glu Arg Trp Asp Gly Val Pro Phe 
    370                 375                 380                 


Ile Leu Arg Cys Gly Lys Ala Leu Asn Glu Arg Lys Ala Glu Val Arg 
385                 390                 395                 400 


Leu Gln Phe His Asp Val Ala Gly Asp Ile Phe His Gln Gln Cys Lys 
                405                 410                 415     


Arg Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Val Tyr Thr 
            420                 425                 430         


Lys Met Met Thr Lys Lys Pro Gly Met Phe Phe Asn Pro Glu Glu Ser 
        435                 440                 445             


Glu Leu Asp Leu Thr Tyr Gly Asn Arg Tyr Lys Asn Val Lys Leu Pro 
    450                 455                 460                 


Asp Ala Tyr Glu Arg Leu Ile Leu Asp Val Phe Cys Gly Ser Gln Met 
465                 470                 475                 480 


His Phe Val Arg Ser Asp Glu Leu Arg Glu Ala Trp Arg Ile Phe Thr 
                485                 490                 495     


Pro Leu Leu His Gln Ile Glu Leu Glu Lys Pro Lys Pro Ile Pro Tyr 
            500                 505                 510         


Ile Tyr Gly Ser Arg Gly Pro Thr Glu Ala Asp Glu Leu Met Lys Arg 
        515                 520                 525             


Val Gly Phe Gln Tyr Glu Gly Thr Tyr Lys Trp Val Asn Pro His Lys 
    530                 535                 540                 


Leu 
545 


<210>  4268
<211>  952
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAA__Homo_sapiens__XP_005257251

<400>  4268

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  4269
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAB1__Homo_sapiens__NP_002030

<400>  4269

Met Ser Gly Gly Glu Val Val Cys Ser Gly Trp Leu Arg Lys Ser Pro 
1               5                   10                  15      


Pro Glu Lys Lys Leu Lys Arg Tyr Ala Trp Lys Arg Arg Trp Phe Val 
            20                  25                  30          


Leu Arg Ser Gly Arg Leu Thr Gly Asp Pro Asp Val Leu Glu Tyr Tyr 
        35                  40                  45              


Lys Asn Asp His Ala Lys Lys Pro Ile Arg Ile Ile Asp Leu Asn Leu 
    50                  55                  60                  


Cys Gln Gln Val Asp Ala Gly Leu Thr Phe Asn Lys Lys Glu Phe Glu 
65                  70                  75                  80  


Asn Ser Tyr Ile Phe Asp Ile Asn Thr Ile Asp Arg Ile Phe Tyr Leu 
                85                  90                  95      


Val Ala Asp Ser Glu Glu Glu Met Asn Lys Trp Val Arg Cys Ile Cys 
            100                 105                 110         


Asp Ile Cys Gly Phe Asn Pro Thr Glu Glu Asp Pro Val Lys Pro Pro 
        115                 120                 125             


Gly Ser Ser Leu Gln Ala Pro Ala Asp Leu Pro Leu Ala Ile Asn Thr 
    130                 135                 140                 


Ala Pro Pro Ser Thr Gln Ala Asp Ser Ser Ser Ala Thr Leu Pro Pro 
145                 150                 155                 160 


Pro Tyr Gln Leu Ile Asn Val Pro Pro His Leu Glu Thr Leu Gly Ile 
                165                 170                 175     


Gln Glu Asp Pro Gln Asp Tyr Leu Leu Leu Ile Asn Cys Gln Ser Lys 
            180                 185                 190         


Lys Pro Glu Pro Thr Arg Thr His Ala Asp Ser Ala Lys Ser Thr Ser 
        195                 200                 205             


Ser Glu Thr Asp Cys Asn Asp Asn Val Pro Ser His Lys Asn Pro Ala 
    210                 215                 220                 


Ser Ser Gln Ser Lys His Gly Met Asn Gly Phe Phe Gln Gln Gln Met 
225                 230                 235                 240 


Ile Tyr Asp Ser Pro Pro Ser Arg Ala Pro Ser Ala Ser Val Asp Ser 
                245                 250                 255     


Ser Leu Tyr Asn Leu Pro Arg Ser Tyr Ser His Asp Val Leu Pro Lys 
            260                 265                 270         


Val Ser Pro Ser Ser Thr Glu Ala Asp Gly Glu Leu Tyr Val Phe Asn 
        275                 280                 285             


Thr Pro Ser Gly Thr Ser Ser Val Glu Thr Gln Met Arg His Val Ser 
    290                 295                 300                 


Ile Ser Tyr Asp Ile Pro Pro Thr Pro Gly Asn Thr Tyr Gln Ile Pro 
305                 310                 315                 320 


Arg Thr Phe Pro Glu Gly Thr Leu Gly Gln Thr Ser Lys Leu Asp Thr 
                325                 330                 335     


Ile Pro Asp Ile Pro Pro Pro Arg Pro Pro Lys Pro His Pro Ala His 
            340                 345                 350         


Asp Arg Ser Pro Val Glu Thr Cys Ser Ile Pro Arg Thr Ala Ser Asp 
        355                 360                 365             


Thr Asp Ser Ser Tyr Cys Ile Pro Thr Ala Gly Met Ser Pro Ser Arg 
    370                 375                 380                 


Ser Asn Thr Ile Ser Thr Val Asp Leu Asn Lys Leu Arg Lys Asp Ala 
385                 390                 395                 400 


Ser Ser Gln Asp Cys Tyr Asp Ile Pro Arg Ala Phe Pro Ser Asp Arg 
                405                 410                 415     


Ser Ser Ser Leu Glu Gly Phe His Asn His Phe Lys Val Lys Asn Val 
            420                 425                 430         


Leu Thr Val Gly Ser Val Ser Ser Glu Glu Leu Asp Glu Asn Tyr Val 
        435                 440                 445             


Pro Met Asn Pro Asn Ser Pro Pro Arg Gln His Ser Ser Ser Phe Thr 
    450                 455                 460                 


Glu Pro Ile Gln Glu Ala Asn Tyr Val Pro Met Thr Pro Gly Thr Phe 
465                 470                 475                 480 


Asp Phe Ser Ser Phe Gly Met Gln Val Pro Pro Pro Ala His Met Gly 
                485                 490                 495     


Phe Arg Ser Ser Pro Lys Thr Pro Pro Arg Arg Pro Val Pro Val Ala 
            500                 505                 510         


Asp Cys Glu Pro Pro Pro Val Asp Arg Asn Leu Lys Pro Asp Arg Lys 
        515                 520                 525             


Val Lys Pro Ala Pro Leu Glu Ile Lys Pro Leu Pro Glu Trp Glu Glu 
    530                 535                 540                 


Leu Gln Ala Pro Val Arg Ser Pro Ile Thr Arg Ser Phe Ala Arg Asp 
545                 550                 555                 560 


Ser Ser Arg Phe Pro Met Ser Pro Arg Pro Asp Ser Val His Ser Thr 
                565                 570                 575     


Thr Ser Ser Ser Asp Ser His Asp Ser Glu Glu Asn Tyr Val Pro Met 
            580                 585                 590         


Asn Pro Asn Leu Ser Ser Glu Asp Pro Asn Leu Phe Gly Ser Asn Ser 
        595                 600                 605             


Leu Asp Gly Gly Ser Ser Pro Met Ile Lys Pro Lys Gly Asp Lys Gln 
    610                 615                 620                 


Val Glu Tyr Leu Asp Leu Asp Leu Asp Ser Gly Lys Ser Thr Pro Pro 
625                 630                 635                 640 


Arg Lys Gln Lys Ser Ser Gly Ser Gly Ser Ser Val Ala Asp Glu Arg 
                645                 650                 655     


Val Asp Tyr Val Val Val Asp Gln Gln Lys Thr Leu Ala Leu Lys Ser 
            660                 665                 670         


Thr Arg Glu Ala Trp Thr Asp Gly Arg Gln Ser Thr Glu Ser Glu Thr 
        675                 680                 685             


Pro Ala Lys Ser Val Lys 
    690                 


<210>  4270
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAB2__Homo_sapiens__NP_036428

<400>  4270

Met Ser Gly Asp Pro Asp Val Leu Glu Tyr Tyr Lys Asn Asp His Ser 
1               5                   10                  15      


Lys Lys Pro Leu Arg Ile Ile Asn Leu Asn Phe Cys Glu Gln Val Asp 
            20                  25                  30          


Ala Gly Leu Thr Phe Asn Lys Lys Glu Leu Gln Asp Ser Phe Val Phe 
        35                  40                  45              


Asp Ile Lys Thr Ser Glu Arg Thr Phe Tyr Leu Val Ala Glu Thr Glu 
    50                  55                  60                  


Glu Asp Met Asn Lys Trp Val Gln Ser Ile Cys Gln Ile Cys Gly Phe 
65                  70                  75                  80  


Asn Gln Ala Glu Glu Ser Thr Asp Ser Leu Arg Asn Val Ser Ser Ala 
                85                  90                  95      


Gly His Gly Pro Arg Ser Ser Pro Ala Glu Leu Ser Ser Ser Ser Gln 
            100                 105                 110         


His Leu Leu Arg Glu Arg Lys Ser Ser Ala Pro Ser His Ser Ser Gln 
        115                 120                 125             


Pro Thr Leu Phe Thr Phe Glu Pro Pro Val Ser Asn His Met Gln Pro 
    130                 135                 140                 


Thr Leu Ser Thr Ser Ala Pro Gln Glu Tyr Leu Tyr Leu His Gln Cys 
145                 150                 155                 160 


Ile Ser Arg Arg Ala Glu Asn Ala Arg Ser Ala Ser Phe Ser Gln Gly 
                165                 170                 175     


Thr Arg Ala Ser Phe Leu Met Arg Ser Asp Thr Ala Val Gln Lys Leu 
            180                 185                 190         


Ala Gln Gly Asn Gly His Cys Val Asn Gly Ile Ser Gly Gln Val His 
        195                 200                 205             


Gly Phe Tyr Ser Leu Pro Lys Pro Ser Arg His Asn Thr Glu Phe Arg 
    210                 215                 220                 


Asp Ser Thr Tyr Asp Leu Pro Arg Ser Leu Ala Ser His Gly His Thr 
225                 230                 235                 240 


Lys Gly Ser Leu Thr Gly Ser Glu Thr Asp Asn Glu Asp Val Tyr Thr 
                245                 250                 255     


Phe Lys Thr Pro Ser Asn Thr Leu Cys Arg Glu Phe Gly Asp Leu Leu 
            260                 265                 270         


Val Asp Asn Met Asp Val Pro Ala Thr Pro Leu Ser Ala Tyr Gln Ile 
        275                 280                 285             


Pro Arg Thr Phe Thr Leu Asp Lys Asn His Asn Ala Met Thr Val Ala 
    290                 295                 300                 


Thr Pro Gly Asp Ser Ala Ile Ala Pro Pro Pro Arg Pro Pro Lys Pro 
305                 310                 315                 320 


Ser Gln Ala Glu Thr Pro Arg Trp Gly Ser Pro Gln Gln Arg Pro Pro 
                325                 330                 335     


Ile Ser Glu Asn Ser Arg Ser Val Ala Ala Thr Ile Pro Arg Arg Asn 
            340                 345                 350         


Thr Leu Pro Ala Met Asp Asn Ser Arg Leu His Arg Ala Ser Ser Cys 
        355                 360                 365             


Glu Thr Tyr Glu Tyr Pro Gln Arg Gly Gly Glu Ser Ala Gly Arg Ser 
    370                 375                 380                 


Ala Glu Ser Met Ser Asp Gly Val Gly Ser Phe Leu Pro Gly Lys Met 
385                 390                 395                 400 


Ile Val Gly Arg Ser Asp Ser Thr Asn Ser Glu Asp Asn Tyr Val Pro 
                405                 410                 415     


Met Asn Pro Gly Ser Ser Thr Leu Leu Ala Met Glu Arg Ala Gly Asp 
            420                 425                 430         


Asn Ser Gln Ser Val Tyr Ile Pro Met Ser Pro Gly Ala His His Phe 
        435                 440                 445             


Asp Ser Leu Gly Tyr Pro Ser Thr Thr Leu Pro Val His Arg Gly Pro 
    450                 455                 460                 


Ser Arg Gly Ser Glu Ile Gln Pro Pro Pro Val Asn Arg Asn Leu Lys 
465                 470                 475                 480 


Pro Asp Arg Lys Ala Lys Pro Thr Pro Leu Asp Leu Arg Asn Asn Thr 
                485                 490                 495     


Val Ile Asp Glu Leu Pro Phe Lys Ser Pro Ile Thr Lys Ser Trp Ser 
            500                 505                 510         


Arg Ala Asn His Thr Phe Asn Ser Ser Ser Ser Gln Tyr Cys Arg Pro 
        515                 520                 525             


Ile Ser Thr Gln Ser Ile Thr Ser Thr Asp Ser Gly Asp Ser Glu Glu 
    530                 535                 540                 


Asn Tyr Val Pro Met Gln Asn Pro Val Ser Ala Ser Pro Val Pro Ser 
545                 550                 555                 560 


Gly Thr Asn Ser Pro Ala Pro Lys Lys Ser Thr Gly Ser Val Asp Tyr 
                565                 570                 575     


Leu Ala Leu Asp Phe Gln Pro Ser Ser Pro Ser Pro His Arg Lys Pro 
            580                 585                 590         


Ser Thr Ser Ser Val Thr Ser Asp Glu Lys Val Asp Tyr Val Gln Val 
        595                 600                 605             


Asp Lys Glu Lys Thr Gln Ala Leu Gln Asn Thr Met Gln Glu Trp Thr 
    610                 615                 620                 


Asp Val Arg Gln Ser Ser Glu Pro Ser Lys Gly Ala Lys Leu 
625                 630                 635             


<210>  4271
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAB3__Homo_sapiens__NP_001075042

<400>  4271

Met Ser Ala Gly Asp Ala Val Cys Thr Gly Trp Leu Val Lys Ser Pro 
1               5                   10                  15      


Pro Glu Arg Lys Leu Gln Arg Tyr Ala Trp Arg Lys Arg Trp Phe Val 
            20                  25                  30          


Leu Arg Arg Gly Arg Met Ser Gly Asn Pro Asp Val Leu Glu Tyr Tyr 
        35                  40                  45              


Arg Asn Lys His Ser Ser Lys Pro Ile Arg Val Ile Asp Leu Ser Glu 
    50                  55                  60                  


Cys Ala Val Trp Lys His Val Gly Pro Ser Phe Val Arg Lys Glu Phe 
65                  70                  75                  80  


Gln Asn Asn Phe Val Phe Ile Val Lys Thr Thr Ser Arg Thr Phe Tyr 
                85                  90                  95      


Leu Val Ala Lys Thr Glu Gln Glu Met Gln Val Trp Val His Ser Ile 
            100                 105                 110         


Ser Gln Val Cys Asn Leu Gly His Leu Glu Asp Gly Ala Ala Asp Ser 
        115                 120                 125             


Met Glu Ser Leu Ser Tyr Thr Pro Ser Ser Leu Gln Pro Ser Ser Ala 
    130                 135                 140                 


Ser Ser Leu Leu Thr Ala His Ala Ala Ser Ser Ser Leu Pro Arg Asp 
145                 150                 155                 160 


Asp Pro Asn Thr Asn Ala Val Ala Thr Glu Glu Thr Arg Ser Glu Ser 
                165                 170                 175     


Glu Leu Leu Phe Leu Pro Asp Tyr Leu Val Leu Ser Asn Cys Glu Thr 
            180                 185                 190         


Gly Arg Leu His His Thr Ser Leu Pro Thr Arg Cys Asp Ser Trp Ser 
        195                 200                 205             


Asn Ser Asp Arg Ser Leu Glu Gln Ala Ser Phe Asp Asp Val Phe Val 
    210                 215                 220                 


Asp Cys Leu Gln Pro Leu Pro Ser Ser His Leu Val His Pro Ser Cys 
225                 230                 235                 240 


His Gly Ser Gly Ala Gln Glu Val Pro Ser Ser Arg Pro Gln Ala Ala 
                245                 250                 255     


Leu Ile Trp Ser Arg Glu Ile Asn Gly Pro Pro Arg Asp His Leu Ser 
            260                 265                 270         


Ser Ser Pro Leu Leu Glu Ser Ser Leu Ser Ser Thr Ile Gln Val Asp 
        275                 280                 285             


Lys Asn Gln Gly Ser Leu Pro Cys Gly Ala Lys Glu Leu Asp Ile Met 
    290                 295                 300                 


Ser Asn Thr Pro Pro Pro Arg Pro Pro Lys Pro Ser His Leu Ser Glu 
305                 310                 315                 320 


Arg Arg Gln Glu Glu Trp Ser Thr His Ser Gly Ser Lys Lys Pro Glu 
                325                 330                 335     


Cys Thr Leu Val Pro Arg Arg Ile Ser Leu Ser Gly Leu Asp Asn Met 
            340                 345                 350         


Arg Thr Trp Lys Ala Asp Val Glu Gly Gln Ser Leu Arg His Arg Asp 
        355                 360                 365             


Lys Arg Leu Ser Leu Asn Leu Pro Cys Arg Phe Ser Pro Met Tyr Pro 
    370                 375                 380                 


Thr Ala Ser Ala Ser Ile Glu Asp Ser Tyr Val Pro Met Ser Pro Gln 
385                 390                 395                 400 


Ala Gly Ala Ser Gly Leu Gly Pro His Cys Ser Pro Asp Asp Tyr Ile 
                405                 410                 415     


Pro Met Asn Ser Gly Ser Ile Ser Ser Pro Leu Pro Glu Leu Pro Ala 
            420                 425                 430         


Asn Leu Glu Pro Pro Pro Val Asn Arg Asp Leu Lys Pro Gln Arg Lys 
        435                 440                 445             


Ser Arg Pro Pro Pro Leu Asp Leu Arg Asn Leu Ser Ile Ile Arg Glu 
    450                 455                 460                 


His Ala Ser Leu Thr Arg Thr Arg Thr Val Pro Cys Ser Arg Thr Ser 
465                 470                 475                 480 


Phe Leu Ser Pro Glu Arg Asn Gly Ile Asn Ser Ala Arg Phe Phe Ala 
                485                 490                 495     


Asn Pro Val Ser Arg Glu Asp Glu Glu Ser Tyr Ile Glu Met Glu Glu 
            500                 505                 510         


His Arg Thr Ala Ser Ser Leu Ser Ser Gly Ala Leu Thr Trp Thr Lys 
        515                 520                 525             


Lys Phe Ser Leu Asp Tyr Leu Ala Leu Asp Phe Asn Ser Ala Ser Pro 
    530                 535                 540                 


Ala Pro Met Gln Gln Lys Leu Leu Leu Ser Glu Glu Gln Arg Val Asp 
545                 550                 555                 560 


Tyr Val Gln Val Asp Glu Gln Lys Thr Gln Ala Leu Gln Ser Thr Lys 
                565                 570                 575     


Gln Glu Trp Thr Asp Glu Arg Gln Ser Lys Val 
            580                 585         


<210>  4272
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABARAP__Homo_sapiens__NP_009209

<400>  4272

Met Lys Phe Val Tyr Lys Glu Glu His Pro Phe Glu Lys Arg Arg Ser 
1               5                   10                  15      


Glu Gly Glu Lys Ile Arg Lys Lys Tyr Pro Asp Arg Val Pro Val Ile 
            20                  25                  30          


Val Glu Lys Ala Pro Lys Ala Arg Ile Gly Asp Leu Asp Lys Lys Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Leu Thr Val Gly Gln Phe Tyr Phe Leu Ile 
    50                  55                  60                  


Arg Lys Arg Ile His Leu Arg Ala Glu Asp Ala Leu Phe Phe Phe Val 
65                  70                  75                  80  


Asn Asn Val Ile Pro Pro Thr Ser Ala Thr Met Gly Gln Leu Tyr Gln 
                85                  90                  95      


Glu His His Glu Glu Asp Phe Phe Leu Tyr Ile Ala Tyr Ser Asp Glu 
            100                 105                 110         


Ser Val Tyr Gly Leu 
        115         


<210>  4273
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABARAPL1__Homo_sapiens__NP_113600

<400>  4273

Met Lys Phe Gln Tyr Lys Glu Asp His Pro Phe Glu Tyr Arg Lys Lys 
1               5                   10                  15      


Glu Gly Glu Lys Ile Arg Lys Lys Tyr Pro Asp Arg Val Pro Val Ile 
            20                  25                  30          


Val Glu Lys Ala Pro Lys Ala Arg Val Pro Asp Leu Asp Lys Arg Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Leu Thr Val Gly Gln Phe Tyr Phe Leu Ile 
    50                  55                  60                  


Arg Lys Arg Ile His Leu Arg Pro Glu Asp Ala Leu Phe Phe Phe Val 
65                  70                  75                  80  


Asn Asn Thr Ile Pro Pro Thr Ser Ala Thr Met Gly Gln Leu Tyr Glu 
                85                  90                  95      


Asp Asn His Glu Glu Asp Tyr Phe Leu Tyr Val Ala Tyr Ser Asp Glu 
            100                 105                 110         


Ser Val Tyr Gly Lys 
        115         


<210>  4274
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABARAPL2__Homo_sapiens__NP_009216

<400>  4274

Met Lys Trp Met Phe Lys Glu Asp His Ser Leu Glu His Arg Cys Val 
1               5                   10                  15      


Glu Ser Ala Lys Ile Arg Ala Lys Tyr Pro Asp Arg Val Pro Val Ile 
            20                  25                  30          


Val Glu Lys Val Ser Gly Ser Gln Ile Val Asp Ile Asp Lys Arg Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Ile Thr Val Ala Gln Phe Met Trp Ile Ile 
    50                  55                  60                  


Arg Lys Arg Ile Gln Leu Pro Ser Glu Lys Ala Ile Phe Leu Phe Val 
65                  70                  75                  80  


Asp Lys Thr Val Pro Gln Ser Ser Leu Thr Met Gly Gln Leu Tyr Glu 
                85                  90                  95      


Lys Glu Lys Asp Glu Asp Gly Phe Leu Tyr Val Ala Tyr Ser Gly Glu 
            100                 105                 110         


Asn Thr Phe Gly Phe 
        115         


<210>  4275
<211>  961
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABBR1__Homo_sapiens__NP_001461

<400>  4275

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575     


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590         


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605             


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620                 


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640 


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655     


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670         


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685             


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700                 


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720 


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735     


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750         


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765             


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780                 


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800 


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815     


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830         


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845             


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860                 


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880 


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895     


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910         


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925             


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940                 


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960 


Lys 
    


<210>  4276
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABBR2__Homo_sapiens__NP_005449

<400>  4276

Met Ala Ser Pro Arg Ser Ser Gly Gln Pro Gly Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Ala Arg Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu 
            20                  25                  30          


Leu Pro Leu Ala Pro Gly Ala Trp Gly Trp Ala Arg Gly Ala Pro Arg 
        35                  40                  45              


Pro Pro Pro Ser Ser Pro Pro Leu Ser Ile Met Gly Leu Met Pro Leu 
    50                  55                  60                  


Thr Lys Glu Val Ala Lys Gly Ser Ile Gly Arg Gly Val Leu Pro Ala 
65                  70                  75                  80  


Val Glu Leu Ala Ile Glu Gln Ile Arg Asn Glu Ser Leu Leu Arg Pro 
                85                  90                  95      


Tyr Phe Leu Asp Leu Arg Leu Tyr Asp Thr Glu Cys Asp Asn Ala Lys 
            100                 105                 110         


Gly Leu Lys Ala Phe Tyr Asp Ala Ile Lys Tyr Gly Pro Asn His Leu 
        115                 120                 125             


Met Val Phe Gly Gly Val Cys Pro Ser Val Thr Ser Ile Ile Ala Glu 
    130                 135                 140                 


Ser Leu Gln Gly Trp Asn Leu Val Gln Leu Ser Phe Ala Ala Thr Thr 
145                 150                 155                 160 


Pro Val Leu Ala Asp Lys Lys Lys Tyr Pro Tyr Phe Phe Arg Thr Val 
                165                 170                 175     


Pro Ser Asp Asn Ala Val Asn Pro Ala Ile Leu Lys Leu Leu Lys His 
            180                 185                 190         


Tyr Gln Trp Lys Arg Val Gly Thr Leu Thr Gln Asp Val Gln Arg Phe 
        195                 200                 205             


Ser Glu Val Arg Asn Asp Leu Thr Gly Val Leu Tyr Gly Glu Asp Ile 
    210                 215                 220                 


Glu Ile Ser Asp Thr Glu Ser Phe Ser Asn Asp Pro Cys Thr Ser Val 
225                 230                 235                 240 


Lys Lys Leu Lys Gly Asn Asp Val Arg Ile Ile Leu Gly Gln Phe Asp 
                245                 250                 255     


Gln Asn Met Ala Ala Lys Val Phe Cys Cys Ala Tyr Glu Glu Asn Met 
            260                 265                 270         


Tyr Gly Ser Lys Tyr Gln Trp Ile Ile Pro Gly Trp Tyr Glu Pro Ser 
        275                 280                 285             


Trp Trp Glu Gln Val His Thr Glu Ala Asn Ser Ser Arg Cys Leu Arg 
    290                 295                 300                 


Lys Asn Leu Leu Ala Ala Met Glu Gly Tyr Ile Gly Val Asp Phe Glu 
305                 310                 315                 320 


Pro Leu Ser Ser Lys Gln Ile Lys Thr Ile Ser Gly Lys Thr Pro Gln 
                325                 330                 335     


Gln Tyr Glu Arg Glu Tyr Asn Asn Lys Arg Ser Gly Val Gly Pro Ser 
            340                 345                 350         


Lys Phe His Gly Tyr Ala Tyr Asp Gly Ile Trp Val Ile Ala Lys Thr 
        355                 360                 365             


Leu Gln Arg Ala Met Glu Thr Leu His Ala Ser Ser Arg His Gln Arg 
    370                 375                 380                 


Ile Gln Asp Phe Asn Tyr Thr Asp His Thr Leu Gly Arg Ile Ile Leu 
385                 390                 395                 400 


Asn Ala Met Asn Glu Thr Asn Phe Phe Gly Val Thr Gly Gln Val Val 
                405                 410                 415     


Phe Arg Asn Gly Glu Arg Met Gly Thr Ile Lys Phe Thr Gln Phe Gln 
            420                 425                 430         


Asp Ser Arg Glu Val Lys Val Gly Glu Tyr Asn Ala Val Ala Asp Thr 
        435                 440                 445             


Leu Glu Ile Ile Asn Asp Thr Ile Arg Phe Gln Gly Ser Glu Pro Pro 
    450                 455                 460                 


Lys Asp Lys Thr Ile Ile Leu Glu Gln Leu Arg Lys Ile Ser Leu Pro 
465                 470                 475                 480 


Leu Tyr Ser Ile Leu Ser Ala Leu Thr Ile Leu Gly Met Ile Met Ala 
                485                 490                 495     


Ser Ala Phe Leu Phe Phe Asn Ile Lys Asn Arg Asn Gln Lys Leu Ile 
            500                 505                 510         


Lys Met Ser Ser Pro Tyr Met Asn Asn Leu Ile Ile Leu Gly Gly Met 
        515                 520                 525             


Leu Ser Tyr Ala Ser Ile Phe Leu Phe Gly Leu Asp Gly Ser Phe Val 
    530                 535                 540                 


Ser Glu Lys Thr Phe Glu Thr Leu Cys Thr Val Arg Thr Trp Ile Leu 
545                 550                 555                 560 


Thr Val Gly Tyr Thr Thr Ala Phe Gly Ala Met Phe Ala Lys Thr Trp 
                565                 570                 575     


Arg Val His Ala Ile Phe Lys Asn Val Lys Met Lys Lys Lys Ile Ile 
            580                 585                 590         


Lys Asp Gln Lys Leu Leu Val Ile Val Gly Gly Met Leu Leu Ile Asp 
        595                 600                 605             


Leu Cys Ile Leu Ile Cys Trp Gln Ala Val Asp Pro Leu Arg Arg Thr 
    610                 615                 620                 


Val Glu Lys Tyr Ser Met Glu Pro Asp Pro Ala Gly Arg Asp Ile Ser 
625                 630                 635                 640 


Ile Arg Pro Leu Leu Glu His Cys Glu Asn Thr His Met Thr Ile Trp 
                645                 650                 655     


Leu Gly Ile Val Tyr Ala Tyr Lys Gly Leu Leu Met Leu Phe Gly Cys 
            660                 665                 670         


Phe Leu Ala Trp Glu Thr Arg Asn Val Ser Ile Pro Ala Leu Asn Asp 
        675                 680                 685             


Ser Lys Tyr Ile Gly Met Ser Val Tyr Asn Val Gly Ile Met Cys Ile 
    690                 695                 700                 


Ile Gly Ala Ala Val Ser Phe Leu Thr Arg Asp Gln Pro Asn Val Gln 
705                 710                 715                 720 


Phe Cys Ile Val Ala Leu Val Ile Ile Phe Cys Ser Thr Ile Thr Leu 
                725                 730                 735     


Cys Leu Val Phe Val Pro Lys Leu Ile Thr Leu Arg Thr Asn Pro Asp 
            740                 745                 750         


Ala Ala Thr Gln Asn Arg Arg Phe Gln Phe Thr Gln Asn Gln Lys Lys 
        755                 760                 765             


Glu Asp Ser Lys Thr Ser Thr Ser Val Thr Ser Val Asn Gln Ala Ser 
    770                 775                 780                 


Thr Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His Arg Leu Arg Met 
785                 790                 795                 800 


Lys Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val Thr Met Gln Leu 
                805                 810                 815     


Gln Asp Thr Pro Glu Lys Thr Thr Tyr Ile Lys Gln Asn His Tyr Gln 
            820                 825                 830         


Glu Leu Asn Asp Ile Leu Asn Leu Gly Asn Phe Thr Glu Ser Thr Asp 
        835                 840                 845             


Gly Gly Lys Ala Ile Leu Lys Asn His Leu Asp Gln Asn Pro Gln Leu 
    850                 855                 860                 


Gln Trp Asn Thr Thr Glu Pro Ser Arg Thr Cys Lys Asp Pro Ile Glu 
865                 870                 875                 880 


Asp Ile Asn Ser Pro Glu His Ile Gln Arg Arg Leu Ser Leu Gln Leu 
                885                 890                 895     


Pro Ile Leu His His Ala Tyr Leu Pro Ser Ile Gly Gly Val Asp Ala 
            900                 905                 910         


Ser Cys Val Ser Pro Cys Val Ser Pro Thr Ala Ser Pro Arg His Arg 
        915                 920                 925             


His Val Pro Pro Ser Phe Arg Val Met Val Ser Gly Leu 
    930                 935                 940     


<210>  4277
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABPA__Homo_sapiens__NP_002031

<400>  4277

Met Thr Lys Arg Glu Ala Glu Glu Leu Ile Glu Ile Glu Ile Asp Gly 
1               5                   10                  15      


Thr Glu Lys Ala Glu Cys Thr Glu Glu Ser Ile Val Glu Gln Thr Tyr 
            20                  25                  30          


Ala Pro Ala Glu Cys Val Ser Gln Ala Ile Asp Ile Asn Glu Pro Ile 
        35                  40                  45              


Gly Asn Leu Lys Lys Leu Leu Glu Pro Arg Leu Gln Cys Ser Leu Asp 
    50                  55                  60                  


Ala His Glu Ile Cys Leu Gln Asp Ile Gln Leu Asp Pro Glu Arg Ser 
65                  70                  75                  80  


Leu Phe Asp Gln Gly Val Lys Thr Asp Gly Thr Val Gln Leu Ser Val 
                85                  90                  95      


Gln Val Ile Ser Tyr Gln Gly Ile Glu Pro Lys Leu Asn Ile Leu Glu 
            100                 105                 110         


Ile Val Lys Pro Ala Asp Thr Val Glu Val Val Ile Asp Pro Asp Ala 
        115                 120                 125             


His His Ala Glu Ser Glu Ala His Leu Val Glu Glu Ala Gln Val Ile 
    130                 135                 140                 


Thr Leu Asp Gly Thr Lys His Ile Thr Thr Ile Ser Asp Glu Thr Ser 
145                 150                 155                 160 


Glu Gln Val Thr Arg Trp Ala Ala Ala Leu Glu Gly Tyr Arg Lys Glu 
                165                 170                 175     


Gln Glu Arg Leu Gly Ile Pro Tyr Asp Pro Ile Gln Trp Ser Thr Asp 
            180                 185                 190         


Gln Val Leu His Trp Val Val Trp Val Met Lys Glu Phe Ser Met Thr 
        195                 200                 205             


Asp Ile Asp Leu Thr Thr Leu Asn Ile Ser Gly Arg Glu Leu Cys Ser 
    210                 215                 220                 


Leu Asn Gln Glu Asp Phe Phe Gln Arg Val Pro Arg Gly Glu Ile Leu 
225                 230                 235                 240 


Trp Ser His Leu Glu Leu Leu Arg Lys Tyr Val Leu Ala Ser Gln Glu 
                245                 250                 255     


Gln Gln Met Asn Glu Ile Val Thr Ile Asp Gln Pro Val Gln Ile Ile 
            260                 265                 270         


Pro Ala Ser Val Gln Ser Ala Thr Pro Thr Thr Ile Lys Val Ile Asn 
        275                 280                 285             


Ser Ser Ala Lys Ala Ala Lys Val Gln Arg Ala Pro Arg Ile Ser Gly 
    290                 295                 300                 


Glu Asp Arg Ser Ser Pro Gly Asn Arg Thr Gly Asn Asn Gly Gln Ile 
305                 310                 315                 320 


Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu Thr Asp Lys Asp Ala Arg 
                325                 330                 335     


Asp Cys Ile Ser Trp Val Gly Asp Glu Gly Glu Phe Lys Leu Asn Gln 
            340                 345                 350         


Pro Glu Leu Val Ala Gln Lys Trp Gly Gln Arg Lys Asn Lys Pro Thr 
        355                 360                 365             


Met Asn Tyr Glu Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Gly 
    370                 375                 380                 


Asp Met Ile Cys Lys Val Gln Gly Lys Arg Phe Val Tyr Lys Phe Val 
385                 390                 395                 400 


Cys Asp Leu Lys Thr Leu Ile Gly Tyr Ser Ala Ala Glu Leu Asn Arg 
                405                 410                 415     


Leu Val Thr Glu Cys Glu Gln Lys Lys Leu Ala Lys Met Gln Leu His 
            420                 425                 430         


Gly Ile Ala Gln Pro Val Thr Ala Val Ala Leu Ala Thr Ala Ser Leu 
        435                 440                 445             


Gln Thr Glu Lys Asp Asn 
    450                 


<210>  4278
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABPB1__Homo_sapiens__NP_002032

<400>  4278

Met Ser Leu Val Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
1               5                   10                  15      


Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Pro Phe 
            20                  25                  30          


Thr Thr Asp Trp Leu Gly Thr Ser Pro Leu His Leu Ala Ala Gln Tyr 
        35                  40                  45              


Gly His Tyr Ser Thr Thr Glu Val Leu Leu Arg Ala Gly Val Ser Arg 
    50                  55                  60                  


Asp Ala Arg Thr Lys Val Asp Arg Thr Pro Leu His Met Ala Ala Ser 
65                  70                  75                  80  


Glu Gly His Ala Ser Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
                85                  90                  95      


Val Asn Ala Lys Asp Met Leu Lys Met Thr Ala Leu His Trp Ala Thr 
            100                 105                 110         


Glu His Asn His Gln Glu Val Val Glu Leu Leu Ile Lys Tyr Gly Ala 
        115                 120                 125             


Asp Val His Thr Gln Ser Lys Phe Cys Lys Thr Ala Phe Asp Ile Ser 
    130                 135                 140                 


Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Ile Ala Met 
145                 150                 155                 160 


Gln Asn Gln Ile Asn Thr Asn Pro Glu Ser Pro Asp Thr Val Thr Ile 
                165                 170                 175     


His Ala Ala Thr Pro Gln Phe Ile Ile Gly Pro Gly Gly Val Val Asn 
            180                 185                 190         


Leu Thr Gly Leu Val Ser Ser Glu Asn Ser Ser Lys Ala Thr Asp Glu 
        195                 200                 205             


Thr Gly Val Ser Ala Val Gln Phe Gly Asn Ser Ser Thr Ser Val Leu 
    210                 215                 220                 


Ala Thr Leu Ala Ala Leu Ala Glu Ala Ser Ala Pro Leu Ser Asn Ser 
225                 230                 235                 240 


Ser Glu Thr Pro Val Val Ala Thr Glu Glu Val Val Thr Ala Glu Ser 
                245                 250                 255     


Val Asp Gly Ala Ile Gln Gln Val Val Ser Ser Gly Gly Gln Gln Val 
            260                 265                 270         


Ile Thr Ile Val Thr Asp Gly Ile Gln Leu Gly Asn Leu His Ser Ile 
        275                 280                 285             


Pro Thr Ser Gly Ile Gly Gln Pro Ile Ile Val Thr Met Pro Asp Gly 
    290                 295                 300                 


Gln Gln Val Leu Thr Val Pro Ala Thr Asp Ile Ala Glu Glu Thr Val 
305                 310                 315                 320 


Ile Ser Glu Glu Pro Pro Ala Lys Arg Gln Cys Ile Glu Ile Ile Glu 
                325                 330                 335     


Asn Arg Val Glu Ser Ala Glu Ile Glu Val Arg Ser Leu Leu Pro Gly 
            340                 345                 350         


Val Leu Cys Arg Ser His Pro Lys 
        355                 360 


<210>  4279
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRA1__Homo_sapiens__NP_001121120

<400>  4279

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  4280
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRA2__Homo_sapiens__NP_000798

<400>  4280

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  4281
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRA3__Homo_sapiens__NP_000799

<400>  4281

Met Ile Ile Thr Gln Thr Ser His Cys Tyr Met Thr Ser Leu Gly Ile 
1               5                   10                  15      


Leu Phe Leu Ile Asn Ile Leu Pro Gly Thr Thr Gly Gln Gly Glu Ser 
            20                  25                  30          


Arg Arg Gln Glu Pro Gly Asp Phe Val Lys Gln Asp Ile Gly Gly Leu 
        35                  40                  45              


Ser Pro Lys His Ala Pro Asp Ile Pro Asp Asp Ser Thr Asp Asn Ile 
    50                  55                  60                  


Thr Ile Phe Thr Arg Ile Leu Asp Arg Leu Leu Asp Gly Tyr Asp Asn 
65                  70                  75                  80  


Arg Leu Arg Pro Gly Leu Gly Asp Ala Val Thr Glu Val Lys Thr Asp 
                85                  90                  95      


Ile Tyr Val Thr Ser Phe Gly Pro Val Ser Asp Thr Asp Met Glu Tyr 
            100                 105                 110         


Thr Ile Asp Val Phe Phe Arg Gln Thr Trp His Asp Glu Arg Leu Lys 
        115                 120                 125             


Phe Asp Gly Pro Met Lys Ile Leu Pro Leu Asn Asn Leu Leu Ala Ser 
    130                 135                 140                 


Lys Ile Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Val 
145                 150                 155                 160 


Ala His Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Val Asp Asn 
                165                 170                 175     


Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr Ile His Ala Glu Cys Pro 
            180                 185                 190         


Met His Leu Glu Asp Phe Pro Met Asp Val His Ala Cys Pro Leu Lys 
        195                 200                 205             


Phe Gly Ser Tyr Ala Tyr Thr Thr Ala Glu Val Val Tyr Ser Trp Thr 
    210                 215                 220                 


Leu Gly Lys Asn Lys Ser Val Glu Val Ala Gln Asp Gly Ser Arg Leu 
225                 230                 235                 240 


Asn Gln Tyr Asp Leu Leu Gly His Val Val Gly Thr Glu Ile Ile Arg 
                245                 250                 255     


Ser Ser Thr Gly Glu Tyr Val Val Met Thr Thr His Phe His Leu Lys 
            260                 265                 270         


Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met 
        275                 280                 285             


Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val 
    290                 295                 300                 


Pro Ala Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr 
305                 310                 315                 320 


Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr 
                325                 330                 335     


Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala 
            340                 345                 350         


Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Ser Trp Ala 
        355                 360                 365             


Trp Glu Gly Lys Lys Val Pro Glu Ala Leu Glu Met Lys Lys Lys Thr 
    370                 375                 380                 


Pro Ala Ala Pro Ala Lys Lys Thr Ser Thr Thr Phe Asn Ile Val Gly 
385                 390                 395                 400 


Thr Thr Tyr Pro Ile Asn Leu Ala Lys Asp Thr Glu Phe Ser Thr Ile 
                405                 410                 415     


Ser Lys Gly Ala Ala Pro Ser Ala Ser Ser Thr Pro Thr Ile Ile Ala 
            420                 425                 430         


Ser Pro Lys Ala Thr Tyr Val Gln Asp Ser Pro Thr Glu Thr Lys Thr 
        435                 440                 445             


Tyr Asn Ser Val Ser Lys Val Asp Lys Ile Ser Arg Ile Ile Phe Pro 
    450                 455                 460                 


Val Leu Phe Ala Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Val Asn 
465                 470                 475                 480 


Arg Glu Ser Ala Ile Lys Gly Met Ile Arg Lys Gln 
                485                 490         


<210>  4282
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRA4__Homo_sapiens__NP_000800

<400>  4282

Met Val Ser Ala Lys Lys Val Pro Ala Ile Ala Leu Ser Ala Gly Val 
1               5                   10                  15      


Ser Phe Ala Leu Leu Arg Phe Leu Cys Leu Ala Val Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Glu Lys Ala Lys 
            340                 345                 350         


Arg Lys Thr Ser Lys Pro Pro Gln Glu Val Pro Ala Ala Pro Val Gln 
        355                 360                 365             


Arg Glu Lys His Pro Glu Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Gly Asn Arg Thr Glu Val Gly Asn His Ser Ser Lys Ser Ser Thr Val 
                405                 410                 415     


Val Gln Glu Ser Ser Lys Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser 
            420                 425                 430         


Pro Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala 
        435                 440                 445             


Arg Ala Leu Pro Ser Ala Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met 
    450                 455                 460                 


Pro Arg Lys Ala Ser Val Gly Ser Ala Ser Thr Arg His Val Phe Gly 
465                 470                 475                 480 


Ser Arg Leu Gln Arg Ile Lys Thr Thr Val Asn Thr Ile Gly Ala Thr 
                485                 490                 495     


Gly Lys Leu Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly 
            500                 505                 510         


Ser Gly Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val 
        515                 520                 525             


Thr Phe Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys 
    530                 535                 540                 


Asp Thr Met Glu Lys Ser Glu Ser Leu Met 
545                 550                 


<210>  4283
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRA5__Homo_sapiens__XP_005268315

<400>  4283

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  4284
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRA6__Homo_sapiens__NP_000802

<400>  4284

Met Ala Ser Ser Leu Pro Trp Leu Cys Ile Ile Leu Trp Leu Glu Asn 
1               5                   10                  15      


Ala Leu Gly Lys Leu Glu Val Glu Gly Asn Phe Tyr Ser Glu Asn Val 
            20                  25                  30          


Ser Arg Ile Leu Asp Asn Leu Leu Glu Gly Tyr Asp Asn Arg Leu Arg 
        35                  40                  45              


Pro Gly Phe Gly Gly Ala Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
    50                  55                  60                  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
65                  70                  75                  80  


Val Phe Phe Arg Gln Thr Trp Thr Asp Glu Arg Leu Lys Phe Gly Gly 
                85                  90                  95      


Pro Thr Glu Ile Leu Ser Leu Asn Asn Leu Met Val Ser Lys Ile Trp 
            100                 105                 110         


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Ile Ala His Asn 
        115                 120                 125             


Met Thr Thr Pro Asn Lys Leu Phe Arg Ile Met Gln Asn Gly Thr Ile 
    130                 135                 140                 


Leu Tyr Thr Met Arg Leu Thr Ile Asn Ala Asp Cys Pro Met Arg Leu 
145                 150                 155                 160 


Val Asn Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
                165                 170                 175     


Tyr Ala Tyr Pro Lys Ser Glu Ile Ile Tyr Thr Trp Lys Lys Gly Pro 
            180                 185                 190         


Leu Tyr Ser Val Glu Val Pro Glu Glu Ser Ser Ser Leu Leu Gln Tyr 
        195                 200                 205             


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Asn Thr 
    210                 215                 220                 


Gly Glu Tyr Val Ile Met Thr Val Tyr Phe His Leu Gln Arg Lys Met 
225                 230                 235                 240 


Gly Tyr Phe Met Ile Gln Ile Tyr Thr Pro Cys Ile Met Thr Val Ile 
                245                 250                 255     


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
            260                 265                 270         


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
        275                 280                 285             


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
    290                 295                 300                 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
305                 310                 315                 320 


Phe Ala Ala Val Asn Tyr Phe Thr Asn Leu Gln Thr Gln Lys Ala Lys 
                325                 330                 335     


Arg Lys Ala Gln Phe Ala Ala Pro Pro Thr Val Thr Ile Ser Lys Ala 
            340                 345                 350         


Thr Glu Pro Leu Glu Ala Glu Ile Val Leu His Pro Asp Ser Lys Tyr 
        355                 360                 365             


His Leu Lys Lys Arg Ile Thr Ser Leu Ser Leu Pro Ile Val Ser Ser 
    370                 375                 380                 


Ser Glu Ala Asn Lys Val Leu Thr Arg Ala Pro Ile Leu Gln Ser Thr 
385                 390                 395                 400 


Pro Val Thr Pro Pro Pro Leu Ser Pro Ala Phe Gly Gly Thr Ser Lys 
                405                 410                 415     


Ile Asp Gln Tyr Ser Arg Ile Leu Phe Pro Val Ala Phe Ala Gly Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr Met Glu Val 
        435                 440                 445             


Ser Ser Ser Val Glu 
    450             


<210>  4285
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRB1__Homo_sapiens__NP_000803

<400>  4285

Met Trp Thr Val Gln Asn Arg Glu Ser Leu Gly Leu Leu Ser Phe Pro 
1               5                   10                  15      


Val Met Ile Thr Met Val Cys Cys Ala His Ser Thr Asn Glu Pro Ser 
            20                  25                  30          


Asn Met Ser Tyr Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Asp Val Gly 
    50                  55                  60                  


Met Arg Ile Asp Val Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ser Trp Lys Asp Lys Arg 
                85                  90                  95      


Leu Ser Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Asn Gly Gly Glu Gly Ala Val Thr Gly Val Asn Lys Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Asp Tyr Lys Met Val Ser Lys Lys Val Glu 
    210                 215                 220                 


Phe Thr Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Thr Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Ser Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Ile Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Lys Gly Pro 
                325                 330                 335     


Gln Lys Lys Gly Ala Ser Lys Gln Asp Gln Ser Ala Asn Glu Lys Asn 
            340                 345                 350         


Lys Leu Glu Met Asn Lys Val Gln Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Ser Thr Leu Glu Ile Arg Asn Glu Thr Ser Gly Ser Glu Val Leu 
    370                 375                 380                 


Thr Ser Val Ser Asp Pro Lys Ala Thr Met Tyr Ser Tyr Asp Ser Ala 
385                 390                 395                 400 


Ser Ile Gln Tyr Arg Lys Pro Leu Ser Ser Arg Glu Ala Tyr Gly Arg 
                405                 410                 415     


Ala Leu Asp Arg His Gly Val Pro Ser Lys Gly Arg Ile Arg Arg Arg 
            420                 425                 430         


Ala Ser Gln Leu Lys Val Lys Ile Pro Asp Leu Thr Asp Val Asn Ser 
        435                 440                 445             


Ile Asp Lys Trp Ser Arg Met Phe Phe Pro Ile Thr Phe Ser Leu Phe 
    450                 455                 460                 


Asn Val Val Tyr Trp Leu Tyr Tyr Val His 
465                 470                 


<210>  4286
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRB2__Homo_sapiens__NP_000804

<400>  4286

Met Trp Arg Val Arg Lys Arg Gly Tyr Phe Gly Ile Trp Ser Phe Pro 
1               5                   10                  15      


Leu Ile Ile Ala Ala Val Cys Ala Gln Ser Val Asn Asp Pro Ser Asn 
            20                  25                  30          


Met Ser Leu Val Lys Glu Thr Val Asp Arg Leu Leu Lys Gly Tyr Asp 
        35                  40                  45              


Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Ala Val Gly Met 
    50                  55                  60                  


Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met Asp 
65                  70                  75                  80  


Tyr Thr Leu Thr Met Tyr Phe Gln Gln Ala Trp Arg Asp Lys Arg Leu 
                85                  90                  95      


Ser Tyr Asn Val Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val Ala 
            100                 105                 110         


Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys Ser 
        115                 120                 125             


Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His Pro 
    130                 135                 140                 


Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala Cys 
145                 150                 155                 160 


Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr Leu 
                165                 170                 175     


Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr Trp 
            180                 185                 190         


Arg Gly Asp Asp Asn Ala Val Thr Gly Val Thr Lys Ile Glu Leu Pro 
        195                 200                 205             


Gln Phe Ser Ile Val Asp Tyr Lys Leu Ile Thr Lys Lys Val Val Phe 
    210                 215                 220                 


Ser Thr Gly Ser Tyr Pro Arg Leu Ser Leu Ser Phe Lys Leu Lys Arg 
225                 230                 235                 240 


Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu Ile 
                245                 250                 255     


Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser Ala 
            260                 265                 270         


Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Ile 
        275                 280                 285             


Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys Ala 
    290                 295                 300                 


Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Met Ala Leu 
305                 310                 315                 320 


Leu Glu Tyr Ala Leu Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro Gln 
                325                 330                 335     


Arg Gln Lys Lys Ala Ala Glu Lys Ala Ala Ser Ala Asn Asn Glu Lys 
            340                 345                 350         


Met Arg Leu Asp Val Asn Lys Met Asp Pro His Glu Asn Ile Leu Leu 
        355                 360                 365             


Ser Thr Leu Glu Ile Lys Asn Glu Met Ala Thr Ser Glu Ala Val Met 
    370                 375                 380                 


Gly Leu Gly Asp Pro Arg Ser Thr Met Leu Ala Tyr Asp Ala Ser Ser 
385                 390                 395                 400 


Ile Gln Tyr Arg Lys Ala Gly Leu Pro Arg His Ser Phe Gly Arg Asn 
                405                 410                 415     


Ala Leu Glu Arg His Val Ala Gln Lys Lys Ser Arg Leu Arg Arg Arg 
            420                 425                 430         


Ala Ser Gln Leu Lys Ile Thr Ile Pro Asp Leu Thr Asp Val Asn Ala 
        435                 440                 445             


Ile Asp Arg Trp Ser Arg Ile Phe Phe Pro Val Val Phe Ser Phe Phe 
    450                 455                 460                 


Asn Ile Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470                 


<210>  4287
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRB3__Homo_sapiens__NP_000805

<400>  4287

Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210>  4288
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRE__Homo_sapiens__NP_004952

<400>  4288

Met Leu Ser Lys Val Leu Pro Val Leu Leu Gly Ile Leu Leu Ile Leu 
1               5                   10                  15      


Gln Ser Arg Val Glu Gly Pro Gln Thr Glu Ser Lys Asn Glu Ala Ser 
            20                  25                  30          


Ser Arg Asp Val Val Tyr Gly Pro Gln Pro Gln Pro Leu Glu Asn Gln 
        35                  40                  45              


Leu Leu Ser Glu Glu Thr Lys Ser Thr Glu Thr Glu Thr Gly Ser Arg 
    50                  55                  60                  


Val Gly Lys Leu Pro Glu Ala Ser Arg Ile Leu Asn Thr Ile Leu Ser 
65                  70                  75                  80  


Asn Tyr Asp His Lys Leu Arg Pro Gly Ile Gly Glu Lys Pro Thr Val 
                85                  90                  95      


Val Thr Val Glu Ile Ser Val Asn Ser Leu Gly Pro Leu Ser Ile Leu 
            100                 105                 110         


Asp Met Glu Tyr Thr Ile Asp Ile Ile Phe Ser Gln Thr Trp Tyr Asp 
        115                 120                 125             


Glu Arg Leu Cys Tyr Asn Asp Thr Phe Glu Ser Leu Val Leu Asn Gly 
    130                 135                 140                 


Asn Val Val Ser Gln Leu Trp Ile Pro Asp Thr Phe Phe Arg Asn Ser 
145                 150                 155                 160 


Lys Arg Thr His Glu His Glu Ile Thr Met Pro Asn Gln Met Val Arg 
                165                 170                 175     


Ile Tyr Lys Asp Gly Lys Val Leu Tyr Thr Ile Arg Met Thr Ile Asp 
            180                 185                 190         


Ala Gly Cys Ser Leu His Met Leu Arg Phe Pro Met Asp Ser His Ser 
        195                 200                 205             


Cys Pro Leu Ser Phe Ser Ser Phe Ser Tyr Pro Glu Asn Glu Met Ile 
    210                 215                 220                 


Tyr Lys Trp Glu Asn Phe Lys Leu Glu Ile Asn Glu Lys Asn Ser Trp 
225                 230                 235                 240 


Lys Leu Phe Gln Phe Asp Phe Thr Gly Val Ser Asn Lys Thr Glu Ile 
                245                 250                 255     


Ile Thr Thr Pro Val Gly Asp Phe Met Val Met Thr Ile Phe Phe Asn 
            260                 265                 270         


Val Ser Arg Arg Phe Gly Tyr Val Ala Phe Gln Asn Tyr Val Pro Ser 
        275                 280                 285             


Ser Val Thr Thr Met Leu Ser Trp Val Ser Phe Trp Ile Lys Thr Glu 
    290                 295                 300                 


Ser Ala Pro Ala Arg Thr Ser Leu Gly Ile Thr Ser Val Leu Thr Met 
305                 310                 315                 320 


Thr Thr Leu Gly Thr Phe Ser Arg Lys Asn Phe Pro Arg Val Ser Tyr 
                325                 330                 335     


Ile Thr Ala Leu Asp Phe Tyr Ile Ala Ile Cys Phe Val Phe Cys Phe 
            340                 345                 350         


Cys Ala Leu Leu Glu Phe Ala Val Leu Asn Phe Leu Ile Tyr Asn Gln 
        355                 360                 365             


Thr Lys Ala His Ala Ser Pro Lys Leu Arg His Pro Arg Ile Asn Ser 
    370                 375                 380                 


Arg Ala His Ala Arg Thr Arg Ala Arg Ser Arg Ala Cys Ala Arg Gln 
385                 390                 395                 400 


His Gln Glu Ala Phe Val Cys Gln Ile Val Thr Thr Glu Gly Ser Asp 
                405                 410                 415     


Gly Glu Glu Arg Pro Ser Cys Ser Ala Gln Gln Pro Pro Ser Pro Gly 
            420                 425                 430         


Ser Pro Glu Gly Pro Arg Ser Leu Cys Ser Lys Leu Ala Cys Cys Glu 
        435                 440                 445             


Trp Cys Lys Arg Phe Lys Lys Tyr Phe Cys Met Val Pro Asp Cys Glu 
    450                 455                 460                 


Gly Ser Thr Trp Gln Gln Gly Arg Leu Cys Ile His Val Tyr Arg Leu 
465                 470                 475                 480 


Asp Asn Tyr Ser Arg Val Val Phe Pro Val Thr Phe Phe Phe Phe Asn 
                485                 490                 495     


Val Leu Tyr Trp Leu Val Cys Leu Asn Leu 
            500                 505     


<210>  4289
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRG1__Homo_sapiens__NP_775807

<400>  4289

Met Gly Pro Leu Lys Ala Phe Leu Phe Ser Pro Phe Leu Leu Arg Ser 
1               5                   10                  15      


Gln Ser Arg Gly Val Arg Leu Val Phe Leu Leu Leu Thr Leu His Leu 
            20                  25                  30          


Gly Asn Cys Val Asp Lys Ala Asp Asp Glu Asp Asp Glu Asp Leu Thr 
        35                  40                  45              


Val Asn Lys Thr Trp Val Leu Ala Pro Lys Ile His Glu Gly Asp Ile 
    50                  55                  60                  


Thr Gln Ile Leu Asn Ser Leu Leu Gln Gly Tyr Asp Asn Lys Leu Arg 
65                  70                  75                  80  


Pro Asp Ile Gly Val Arg Pro Thr Val Ile Glu Thr Asp Val Tyr Val 
                85                  90                  95      


Asn Ser Ile Gly Pro Val Asp Pro Ile Asn Met Glu Tyr Thr Ile Asp 
            100                 105                 110         


Ile Ile Phe Ala Gln Thr Trp Phe Asp Ser Arg Leu Lys Phe Asn Ser 
        115                 120                 125             


Thr Met Lys Val Leu Met Leu Asn Ser Asn Met Val Gly Lys Ile Trp 
    130                 135                 140                 


Ile Pro Asp Thr Phe Phe Arg Asn Ser Arg Lys Ser Asp Ala His Trp 
145                 150                 155                 160 


Ile Thr Thr Pro Asn Arg Leu Leu Arg Ile Trp Asn Asp Gly Arg Val 
                165                 170                 175     


Leu Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Tyr Leu Gln Leu 
            180                 185                 190         


His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe Ser Ser 
        195                 200                 205             


Tyr Gly Tyr Pro Lys Asn Glu Ile Glu Tyr Lys Trp Lys Lys Pro Ser 
    210                 215                 220                 


Val Glu Val Ala Asp Pro Lys Tyr Trp Arg Leu Tyr Gln Phe Ala Phe 
225                 230                 235                 240 


Val Gly Leu Arg Asn Ser Thr Glu Ile Thr His Thr Ile Ser Gly Asp 
                245                 250                 255     


Tyr Val Ile Met Thr Ile Phe Phe Asp Leu Ser Arg Arg Met Gly Tyr 
            260                 265                 270         


Phe Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser 
        275                 280                 285             


Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg Thr Ser 
    290                 295                 300                 


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala 
305                 310                 315                 320 


Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp Leu Phe 
                325                 330                 335     


Val Ser Val Cys Phe Ile Phe Val Phe Ala Ala Leu Met Glu Tyr Gly 
            340                 345                 350         


Thr Leu His Tyr Phe Thr Ser Asn Gln Lys Gly Lys Thr Ala Thr Lys 
        355                 360                 365             


Asp Arg Lys Leu Lys Asn Lys Ala Ser Met Thr Pro Gly Leu His Pro 
    370                 375                 380                 


Gly Ser Thr Leu Ile Pro Met Asn Asn Ile Ser Val Pro Gln Glu Asp 
385                 390                 395                 400 


Asp Tyr Gly Tyr Gln Cys Leu Glu Gly Lys Asp Cys Ala Ser Phe Phe 
                405                 410                 415     


Cys Cys Phe Glu Asp Cys Arg Thr Gly Ser Trp Arg Glu Gly Arg Ile 
            420                 425                 430         


His Ile Arg Ile Ala Lys Ile Asp Ser Tyr Ser Arg Ile Phe Phe Pro 
        435                 440                 445             


Thr Ala Phe Ala Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr Leu Tyr 
    450                 455                 460                 


Leu 
465 


<210>  4290
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRG2__Homo_sapiens__NP_000807

<400>  4290

Met Ser Ser Pro Asn Ile Trp Ser Thr Gly Ser Ser Val Tyr Ser Thr 
1               5                   10                  15      


Pro Val Phe Ser Gln Lys Met Thr Val Trp Ile Leu Leu Leu Leu Ser 
            20                  25                  30          


Leu Tyr Pro Gly Phe Thr Ser Gln Lys Ser Asp Asp Asp Tyr Glu Asp 
        35                  40                  45              


Tyr Ala Ser Asn Lys Thr Trp Val Leu Thr Pro Lys Val Pro Glu Gly 
    50                  55                  60                  


Asp Val Thr Val Ile Leu Asn Asn Leu Leu Glu Gly Tyr Asp Asn Lys 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Gly Val Lys Pro Thr Leu Ile His Thr Asp Met 
                85                  90                  95      


Tyr Val Asn Ser Ile Gly Pro Val Asn Ala Ile Asn Met Glu Tyr Thr 
            100                 105                 110         


Ile Asp Ile Phe Phe Ala Gln Thr Trp Tyr Asp Arg Arg Leu Lys Phe 
        115                 120                 125             


Asn Ser Thr Ile Lys Val Leu Arg Leu Asn Ser Asn Met Val Gly Lys 
    130                 135                 140                 


Ile Trp Ile Pro Asp Thr Phe Phe Arg Asn Ser Lys Lys Ala Asp Ala 
145                 150                 155                 160 


His Trp Ile Thr Thr Pro Asn Arg Met Leu Arg Ile Trp Asn Asp Gly 
                165                 170                 175     


Arg Val Leu Tyr Thr Leu Arg Leu Thr Ile Asp Ala Glu Cys Gln Leu 
            180                 185                 190         


Gln Leu His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe 
        195                 200                 205             


Ser Ser Tyr Gly Tyr Pro Arg Glu Glu Ile Val Tyr Gln Trp Lys Arg 
    210                 215                 220                 


Ser Ser Val Glu Val Gly Asp Thr Arg Ser Trp Arg Leu Tyr Gln Phe 
225                 230                 235                 240 


Ser Phe Val Gly Leu Arg Asn Thr Thr Glu Val Val Lys Thr Thr Ser 
                245                 250                 255     


Gly Asp Tyr Val Val Met Ser Val Tyr Phe Asp Leu Ser Arg Arg Met 
            260                 265                 270         


Gly Tyr Phe Thr Ile Gln Thr Tyr Ile Pro Cys Thr Leu Ile Val Val 
        275                 280                 285             


Leu Ser Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg 
    290                 295                 300                 


Thr Ser Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr 
305                 310                 315                 320 


Ile Ala Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp 
                325                 330                 335     


Leu Phe Val Ser Val Cys Phe Ile Phe Val Phe Ser Ala Leu Val Glu 
            340                 345                 350         


Tyr Gly Thr Leu His Tyr Phe Val Ser Asn Arg Lys Pro Ser Lys Asp 
        355                 360                 365             


Lys Asp Lys Lys Lys Lys Asn Pro Ala Pro Thr Ile Asp Ile Arg Pro 
    370                 375                 380                 


Arg Ser Ala Thr Ile Gln Met Asn Asn Ala Thr His Leu Gln Glu Arg 
385                 390                 395                 400 


Asp Glu Glu Tyr Gly Tyr Glu Cys Leu Asp Gly Lys Asp Cys Ala Ser 
                405                 410                 415     


Phe Phe Cys Cys Phe Glu Asp Cys Arg Thr Gly Ala Trp Arg His Gly 
            420                 425                 430         


Arg Ile His Ile Arg Ile Ala Lys Met Asp Ser Tyr Ala Arg Ile Phe 
        435                 440                 445             


Phe Pro Thr Ala Phe Cys Leu Phe Asn Leu Val Tyr Trp Val Ser Tyr 
    450                 455                 460                 


Leu Tyr Leu 
465         


<210>  4291
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRG3__Homo_sapiens__NP_001257802

<400>  4291

Met Ala Pro Lys Leu Leu Leu Leu Leu Cys Leu Phe Ser Gly Leu His 
1               5                   10                  15      


Ala Arg Ser Arg Lys Val Glu Glu Asp Glu Tyr Glu Asp Ser Ser Ser 
            20                  25                  30          


Asn Gln Lys Trp Val Leu Ala Pro Lys Ser Gln Asp Thr Asp Val Thr 
        35                  40                  45              


Leu Ile Leu Asn Lys Leu Leu Arg Glu Tyr Asp Lys Lys Leu Arg Pro 
    50                  55                  60                  


Asp Ile Gly Ile Lys Pro Thr Val Ile Asp Val Asp Ile Tyr Val Asn 
65                  70                  75                  80  


Ser Ile Gly Pro Val Ser Ser Ile Asn Met Glu Tyr Gln Ile Asp Ile 
                85                  90                  95      


Phe Phe Ala Gln Thr Trp Thr Asp Ser Arg Leu Arg Phe Asn Ser Thr 
            100                 105                 110         


Met Lys Ile Leu Thr Leu Asn Ser Asn Met Val Gly Leu Ile Trp Ile 
        115                 120                 125             


Pro Asp Thr Ile Phe Arg Asn Ser Lys Thr Ala Glu Ala His Trp Ile 
    130                 135                 140                 


Thr Thr Pro Asn Gln Leu Leu Arg Ile Trp Asn Asp Gly Lys Ile Leu 
145                 150                 155                 160 


Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Gln Leu Gln Leu His 
                165                 170                 175     


Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Ile Phe Ser Ser Tyr 
            180                 185                 190         


Gly Tyr Pro Lys Glu Glu Met Ile Tyr Arg Trp Arg Lys Asn Ser Val 
        195                 200                 205             


Glu Ala Ala Asp Gln Lys Ser Trp Arg Leu Tyr Gln Phe Asp Phe Met 
    210                 215                 220                 


Gly Leu Arg Asn Thr Thr Glu Ile Val Thr Thr Ser Ala Gly Arg Asn 
225                 230                 235                 240 


Leu Leu Lys Glu Ala Gln Leu Ser Lys Ala Arg Glu Ala 
                245                 250             


<210>  4292
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRP__Homo_sapiens__XP_011532807

<400>  4292

Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr 
1               5                   10                  15      


Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg 
            20                  25                  30          


Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr 
        35                  40                  45              


Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala 
    50                  55                  60                  


Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg 
                85                  90                  95      


Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val 
            100                 105                 110         


Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser 
        115                 120                 125             


Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser 
    130                 135                 140                 


Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys 
145                 150                 155                 160 


Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu 
                165                 170                 175     


Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp 
            180                 185                 190         


Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala 
        195                 200                 205             


Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln 
    210                 215                 220                 


Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg 
225                 230                 235                 240 


Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu 
                245                 250                 255     


Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro 
            260                 265                 270         


Ala Arg Thr Cys Ile Gly Val Thr Thr Val Leu Ser Met Thr Thr Leu 
        275                 280                 285             


Met Ile Gly Ser Arg Thr Ser Leu Pro Asn Thr Asn Cys Phe Ile Lys 
    290                 295                 300                 


Ala Ile Asp Val Tyr Leu Gly Ile Cys Phe Ser Phe Val Phe Gly Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Val Ala His Tyr Ser Ser Leu Gln Gln Met Ala 
                325                 330                 335     


Ala Lys Asp Arg Gly Thr Thr Lys Glu Val Glu Glu Val Ser Ile Thr 
            340                 345                 350         


Asn Ile Ile Asn Ser Ser Ile Ser Ser Phe Lys Arg Lys Ile Ser Phe 
        355                 360                 365             


Ala Ser Ile Glu Ile Ser Ser Asp Asn Val Asp Tyr Ser Asp Leu Thr 
    370                 375                 380                 


Met Lys Thr Ser Asp Lys Phe Lys Phe Val Phe Arg Glu Lys Met Gly 
385                 390                 395                 400 


Arg Ile Val Asp Tyr Phe Thr Ile Gln Asn Pro Ser Asn Val Asp His 
                405                 410                 415     


Tyr Ser Lys Leu Leu Phe Pro Leu Ile Phe Met Leu Ala Asn Val Phe 
            420                 425                 430         


Tyr Trp Ala Tyr Tyr Met Tyr Phe 
        435                 440 


<210>  4293
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRQ__Homo_sapiens__NP_061028

<400>  4293

Met Gly Ile Arg Gly Met Leu Arg Ala Ala Val Ile Leu Leu Leu Ile 
1               5                   10                  15      


Arg Thr Trp Leu Ala Glu Gly Asn Tyr Pro Ser Pro Ile Pro Lys Phe 
            20                  25                  30          


His Phe Glu Phe Ser Ser Ala Val Pro Glu Val Val Leu Asn Leu Phe 
        35                  40                  45              


Asn Cys Lys Asn Cys Ala Asn Glu Ala Val Val Gln Lys Ile Leu Asp 
    50                  55                  60                  


Arg Val Leu Ser Arg Tyr Asp Val Arg Leu Arg Pro Asn Phe Gly Gly 
65                  70                  75                  80  


Ala Pro Val Pro Val Arg Ile Ser Ile Tyr Val Thr Ser Ile Glu Gln 
                85                  90                  95      


Ile Ser Glu Met Asn Met Asp Tyr Thr Ile Thr Met Phe Phe His Gln 
            100                 105                 110         


Thr Trp Lys Asp Ser Arg Leu Ala Tyr Tyr Glu Thr Thr Leu Asn Leu 
        115                 120                 125             


Thr Leu Asp Tyr Arg Met His Glu Lys Leu Trp Val Pro Asp Cys Tyr 
    130                 135                 140                 


Phe Leu Asn Ser Lys Asp Ala Phe Val His Asp Val Thr Val Glu Asn 
145                 150                 155                 160 


Arg Val Phe Gln Leu His Pro Asp Gly Thr Val Arg Tyr Gly Ile Arg 
                165                 170                 175     


Leu Thr Thr Thr Ala Ala Cys Ser Leu Asp Leu His Lys Phe Pro Met 
            180                 185                 190         


Asp Lys Gln Ala Cys Asn Leu Val Val Glu Ser Tyr Gly Tyr Thr Val 
        195                 200                 205             


Glu Asp Ile Ile Leu Phe Trp Asp Asp Asn Gly Asn Ala Ile His Met 
    210                 215                 220                 


Thr Glu Glu Leu His Ile Pro Gln Phe Thr Phe Leu Gly Arg Thr Ile 
225                 230                 235                 240 


Thr Ser Lys Glu Val Tyr Phe Tyr Thr Gly Ser Tyr Ile Arg Leu Ile 
                245                 250                 255     


Leu Lys Phe Gln Val Gln Arg Glu Val Asn Ser Tyr Leu Val Gln Val 
            260                 265                 270         


Tyr Trp Pro Thr Val Leu Thr Thr Ile Thr Ser Trp Ile Ser Phe Trp 
        275                 280                 285             


Met Asn Tyr Asp Ser Ser Ala Ala Arg Val Thr Ile Gly Leu Thr Ser 
    290                 295                 300                 


Met Leu Ile Leu Thr Thr Ile Asp Ser His Leu Arg Asp Lys Leu Pro 
305                 310                 315                 320 


Asn Ile Ser Cys Ile Lys Ala Ile Asp Ile Tyr Ile Leu Val Cys Leu 
                325                 330                 335     


Phe Phe Val Phe Leu Ser Leu Leu Glu Tyr Val Tyr Ile Asn Tyr Leu 
            340                 345                 350         


Phe Tyr Ser Arg Gly Pro Arg Arg Gln Pro Arg Arg His Arg Arg Pro 
        355                 360                 365             


Arg Arg Val Ile Ala Arg Tyr Arg Tyr Gln Gln Val Val Val Gly Asn 
    370                 375                 380                 


Val Gln Asp Gly Leu Ile Asn Val Glu Asp Gly Val Ser Ser Leu Pro 
385                 390                 395                 400 


Ile Thr Pro Ala Gln Ala Pro Leu Ala Ser Pro Glu Ser Leu Gly Ser 
                405                 410                 415     


Leu Thr Ser Thr Ser Glu Gln Ala Gln Leu Ala Thr Ser Glu Ser Leu 
            420                 425                 430         


Ser Pro Leu Thr Ser Leu Ser Gly Gln Ala Pro Leu Ala Thr Gly Glu 
        435                 440                 445             


Ser Leu Ser Asp Leu Pro Ser Thr Ser Glu Gln Ala Arg His Ser Tyr 
    450                 455                 460                 


Gly Val Arg Phe Asn Gly Phe Gln Ala Asp Asp Ser Ile Ile Pro Thr 
465                 470                 475                 480 


Glu Ile Arg Asn Arg Val Glu Ala His Gly His Gly Val Thr His Asp 
                485                 490                 495     


His Glu Asp Ser Asn Glu Ser Leu Ser Ser Asp Glu Arg His Gly His 
            500                 505                 510         


Gly Pro Ser Gly Lys Pro Met Leu His His Gly Glu Lys Gly Val Gln 
        515                 520                 525             


Glu Ala Gly Trp Asp Leu Asp Asp Asn Asn Asp Lys Ser Asp Cys Leu 
    530                 535                 540                 


Ala Ile Lys Glu Gln Phe Lys Cys Asp Thr Asn Ser Thr Trp Gly Leu 
545                 550                 555                 560 


Asn Asp Asp Glu Leu Met Ala His Gly Gln Glu Lys Asp Ser Ser Ser 
                565                 570                 575     


Glu Ser Glu Asp Ser Cys Pro Pro Ser Pro Gly Cys Ser Phe Thr Glu 
            580                 585                 590         


Gly Phe Ser Phe Asp Leu Phe Asn Pro Asp Tyr Val Pro Lys Val Asp 
        595                 600                 605             


Lys Trp Ser Arg Phe Leu Phe Pro Leu Ala Phe Gly Leu Phe Asn Ile 
    610                 615                 620                 


Val Tyr Trp Val Tyr His Met Tyr 
625                 630         


<210>  4294
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRR1__Homo_sapiens__NP_001243632

<400>  4294

Met Leu Ala Val Pro Asn Met Arg Phe Gly Ile Phe Leu Leu Trp Trp 
1               5                   10                  15      


Gly Trp Val Leu Ala Thr Glu Ser Arg Met His Trp Pro Gly Arg Glu 
            20                  25                  30          


Val His Glu Met Ser Lys Lys Gly Ser Pro Ile Leu Arg Arg Ser Pro 
        35                  40                  45              


Asp Ile Thr Lys Ser Pro Leu Thr Lys Ser Glu Gln Leu Leu Arg Ile 
    50                  55                  60                  


Asp Asp His Asp Phe Ser Met Arg Pro Gly Phe Gly Gly Pro Ala Ile 
65                  70                  75                  80  


Pro Val Gly Val Asp Val Gln Val Glu Ser Leu Asp Ser Ile Ser Glu 
                85                  90                  95      


Val Asp Met Asp Phe Thr Met Thr Leu Tyr Leu Arg His Tyr Trp Lys 
            100                 105                 110         


Asp Glu Arg Leu Ser Phe Pro Ser Thr Asn Asn Leu Ser Met Thr Phe 
        115                 120                 125             


Asp Gly Arg Leu Val Lys Lys Ile Trp Val Pro Asp Met Phe Phe Val 
    130                 135                 140                 


His Ser Lys Arg Ser Phe Ile His Asp Thr Thr Thr Asp Asn Val Met 
145                 150                 155                 160 


Leu Arg Val Gln Pro Asp Gly Lys Val Leu Tyr Ser Leu Arg Val Thr 
                165                 170                 175     


Val Thr Ala Met Cys Asn Met Asp Phe Ser Arg Phe Pro Leu Asp Thr 
            180                 185                 190         


Gln Thr Cys Ser Leu Glu Ile Glu Ser Tyr Ala Tyr Thr Glu Asp Asp 
        195                 200                 205             


Leu Met Leu Tyr Trp Lys Lys Gly Asn Asp Ser Leu Lys Thr Asp Glu 
    210                 215                 220                 


Arg Ile Ser Leu Ser Gln Phe Leu Ile Gln Glu Phe His Thr Thr Thr 
225                 230                 235                 240 


Lys Leu Ala Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr Ile 
                245                 250                 255     


Asn Phe Thr Leu Arg Arg His Ile Phe Phe Phe Leu Leu Gln Thr Tyr 
            260                 265                 270         


Phe Pro Ala Thr Leu Met Val Met Leu Ser Trp Val Ser Phe Trp Ile 
        275                 280                 285             


Asp Arg Arg Ala Val Pro Ala Arg Val Pro Leu Gly Ile Thr Thr Val 
    290                 295                 300                 


Leu Thr Met Ser Thr Ile Ile Thr Gly Val Asn Ala Ser Met Pro Arg 
305                 310                 315                 320 


Val Ser Tyr Ile Lys Ala Val Asp Ile Tyr Leu Trp Val Ser Phe Val 
                325                 330                 335     


Phe Val Phe Leu Ser Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu Thr 
            340                 345                 350         


Thr Val Gln Glu Arg Lys Glu Gln Lys Leu Arg Glu Lys Leu Pro Cys 
        355                 360                 365             


Thr Ser Gly Leu Pro Pro Pro Arg Thr Ala Met Leu Asp Gly Asn Tyr 
    370                 375                 380                 


Ser Asp Gly Glu Val Asn Asp Leu Asp Asn Tyr Met Pro Glu Asn Gly 
385                 390                 395                 400 


Glu Lys Pro Asp Arg Met Met Val Gln Leu Thr Leu Ala Ser Glu Arg 
                405                 410                 415     


Ser Ser Pro Gln Arg Lys Ser Gln Arg Ser Ser Tyr Val Ser Met Arg 
            420                 425                 430         


Ile Asp Thr His Ala Ile Asp Lys Tyr Ser Arg Ile Ile Phe Pro Ala 
        435                 440                 445             


Ala Tyr Ile Leu Phe Asn Leu Ile Tyr Trp Ser Ile Phe Ser 
    450                 455                 460         


<210>  4295
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GABRR2__Homo_sapiens__NP_002034

<400>  4295

Met Pro Tyr Phe Thr Arg Leu Ile Leu Phe Leu Phe Cys Leu Met Val 
1               5                   10                  15      


Leu Val Glu Ser Arg Lys Pro Lys Arg Lys Arg Trp Thr Gly Gln Val 
            20                  25                  30          


Glu Met Pro Lys Pro Ser His Leu Tyr Lys Lys Asn Leu Asp Val Thr 
        35                  40                  45              


Lys Ile Arg Lys Gly Lys Pro Gln Gln Leu Leu Arg Val Asp Glu His 
    50                  55                  60                  


Asp Phe Ser Met Arg Pro Ala Phe Gly Gly Pro Ala Ile Pro Val Gly 
65                  70                  75                  80  


Val Asp Val Gln Val Glu Ser Leu Asp Ser Ile Ser Glu Val Asp Met 
                85                  90                  95      


Asp Phe Thr Met Thr Leu Tyr Leu Arg His Tyr Trp Lys Asp Glu Arg 
            100                 105                 110         


Leu Ala Phe Ser Ser Ala Ser Asn Lys Ser Met Thr Phe Asp Gly Arg 
        115                 120                 125             


Leu Val Lys Lys Ile Trp Val Pro Asp Val Phe Phe Val His Ser Lys 
    130                 135                 140                 


Arg Ser Phe Thr His Asp Thr Thr Thr Asp Asn Ile Met Leu Arg Val 
145                 150                 155                 160 


Phe Pro Asp Gly His Val Leu Tyr Ser Met Arg Ile Thr Val Thr Ala 
                165                 170                 175     


Met Cys Asn Met Asp Phe Ser His Phe Pro Leu Asp Ser Gln Thr Cys 
            180                 185                 190         


Ser Leu Glu Leu Glu Ser Tyr Ala Tyr Thr Asp Glu Asp Leu Met Leu 
        195                 200                 205             


Tyr Trp Lys Asn Gly Asp Glu Ser Leu Lys Thr Asp Glu Lys Ile Ser 
    210                 215                 220                 


Leu Ser Gln Phe Leu Ile Gln Lys Phe His Thr Thr Ser Arg Leu Ala 
225                 230                 235                 240 


Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr Ile Asn Phe Thr 
                245                 250                 255     


Leu Arg Arg His Ile Phe Phe Phe Leu Leu Gln Thr Tyr Phe Pro Ala 
            260                 265                 270         


Thr Leu Met Val Met Leu Ser Trp Val Ser Phe Trp Ile Asp Arg Arg 
        275                 280                 285             


Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu Thr Met 
    290                 295                 300                 


Thr Thr Ile Ile Thr Gly Val Asn Ala Ser Met Pro Arg Val Ser Tyr 
305                 310                 315                 320 


Val Lys Ala Val Asp Ile Tyr Leu Trp Val Ser Phe Val Phe Val Phe 
                325                 330                 335     


Leu Ser Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu Thr Thr Val Gln 
            340                 345                 350         


Glu Arg Lys Glu Arg Lys Leu Arg Glu Lys Phe Pro Cys Met Cys Gly 
        355                 360                 365             


Met Leu His Ser Lys Thr Met Met Leu Asp Gly Ser Tyr Ser Glu Ser 
    370                 375                 380                 


Glu Ala Asn Ser Leu Ala Gly Tyr Pro Arg Ser His Ile Leu Thr Glu 
385                 390                 395                 400 


Glu Glu Arg Gln Asp Lys Ile Val Val His Leu Gly Leu Ser Gly Glu 
                405                 410                 415     


Ala Asn Ala Ala Arg Lys Lys Gly Leu Leu Lys Gly Gln Thr Gly Phe 
            420                 425                 430         


Arg Ile Phe Gln Asn Thr His Ala Ile Asp Lys Tyr Ser Arg Leu Ile 
        435                 440                 445             


Phe Pro Ala Ser Tyr Ile Phe Phe Asn Leu Ile Tyr Trp Ser Val Phe 
    450                 455                 460                 


Ser 
465 


<210>  4296
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAD1__Homo_sapiens__NP_000808

<400>  4296

Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15      


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30          


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45              


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60                  


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80  


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95      


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110         


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125             


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140                 


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160 


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175     


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190         


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205             


Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 
    210                 215                 220                 


Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 
225                 230                 235                 240 


Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 
                245                 250                 255     


Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 
            260                 265                 270         


Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 
        275                 280                 285             


Gln Ser His Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 
    290                 295                 300                 


Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Lys Ile Ile 
305                 310                 315                 320 


Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 
                325                 330                 335     


Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 
            340                 345                 350         


Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 
        355                 360                 365             


Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 
    370                 375                 380                 


Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 
385                 390                 395                 400 


Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 
                405                 410                 415     


Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 
            420                 425                 430         


Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 
        435                 440                 445             


Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 
    450                 455                 460                 


Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 
465                 470                 475                 480 


Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 
                485                 490                 495     


Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 
            500                 505                 510         


Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 
        515                 520                 525             


Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 
    530                 535                 540                 


Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 
545                 550                 555                 560 


Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 
                565                 570                 575     


Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 
            580                 585                 590         


Asp Leu 
        


<210>  4297
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAD2__Homo_sapiens__NP_001127838

<400>  4297

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly 
1               5                   10                  15      


Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val 
            20                  25                  30          


Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu 
        35                  40                  45              


Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro 
    50                  55                  60                  


Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys 
65                  70                  75                  80  


Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp 
                85                  90                  95      


Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln 
            100                 105                 110         


Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg 
        115                 120                 125             


Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu 
    130                 135                 140                 


Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu 
145                 150                 155                 160 


Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro 
                165                 170                 175     


Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala 
            180                 185                 190         


Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu 
        195                 200                 205             


Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met 
    210                 215                 220                 


Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser 
225                 230                 235                 240 


Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe 
                245                 250                 255     


Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg 
            260                 265                 270         


Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly 
        275                 280                 285             


Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys 
    290                 295                 300                 


Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu 
305                 310                 315                 320 


Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala 
                325                 330                 335     


Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 
            340                 345                 350         


Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly 
        355                 360                 365             


Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val 
    370                 375                 380                 


Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val 
385                 390                 395                 400 


Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln 
                405                 410                 415     


Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His 
            420                 425                 430         


Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg 
        435                 440                 445             


His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr 
    450                 455                 460                 


Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr 
465                 470                 475                 480 


Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp 
                485                 490                 495     


Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser 
            500                 505                 510         


Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys 
        515                 520                 525             


Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met 
    530                 535                 540                 


Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 
545                 550                 555                 560 


Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu 
                565                 570                 575     


Glu Ile Glu Arg Leu Gly Gln Asp Leu 
            580                 585 


<210>  4298
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GADD45B__Homo_sapiens__NP_056490

<400>  4298

Met Thr Leu Glu Glu Leu Val Ala Cys Asp Asn Ala Ala Gln Lys Met 
1               5                   10                  15      


Gln Thr Val Thr Ala Ala Val Glu Glu Leu Leu Val Ala Ala Gln Arg 
            20                  25                  30          


Gln Asp Arg Leu Thr Val Gly Val Tyr Glu Ser Ala Lys Leu Met Asn 
        35                  40                  45              


Val Asp Pro Asp Ser Val Val Leu Cys Leu Leu Ala Ile Asp Glu Glu 
    50                  55                  60                  


Glu Glu Asp Asp Ile Ala Leu Gln Ile His Phe Thr Leu Ile Gln Ser 
65                  70                  75                  80  


Phe Cys Cys Asp Asn Asp Ile Asn Ile Val Arg Val Ser Gly Met Gln 
                85                  90                  95      


Arg Leu Ala Gln Leu Leu Gly Glu Pro Ala Glu Thr Gln Gly Thr Thr 
            100                 105                 110         


Glu Ala Arg Asp Leu His Cys Leu Leu Val Thr Asn Pro His Thr Asp 
        115                 120                 125             


Ala Trp Lys Ser His Gly Leu Val Glu Val Ala Ser Tyr Cys Glu Glu 
    130                 135                 140                 


Ser Arg Gly Asn Asn Gln Trp Val Pro Tyr Ile Ser Leu Gln Glu Arg 
145                 150                 155                 160 


<210>  4299
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GADD45G__Homo_sapiens__NP_006696

<400>  4299

Met Thr Leu Glu Glu Val Arg Gly Gln Asp Thr Val Pro Glu Ser Thr 
1               5                   10                  15      


Ala Arg Met Gln Gly Ala Gly Lys Ala Leu His Glu Leu Leu Leu Ser 
            20                  25                  30          


Ala Gln Arg Gln Gly Cys Leu Thr Ala Gly Val Tyr Glu Ser Ala Lys 
        35                  40                  45              


Val Leu Asn Val Asp Pro Asp Asn Val Thr Phe Cys Val Leu Ala Ala 
    50                  55                  60                  


Gly Glu Glu Asp Glu Gly Asp Ile Ala Leu Gln Ile His Phe Thr Leu 
65                  70                  75                  80  


Ile Gln Ala Phe Cys Cys Glu Asn Asp Ile Asp Ile Val Arg Val Gly 
                85                  90                  95      


Asp Val Gln Arg Leu Ala Ala Ile Val Gly Ala Gly Glu Glu Ala Gly 
            100                 105                 110         


Ala Pro Gly Asp Leu His Cys Ile Leu Ile Ser Asn Pro Asn Glu Asp 
        115                 120                 125             


Ala Trp Lys Asp Pro Ala Leu Glu Lys Leu Ser Leu Phe Cys Glu Glu 
    130                 135                 140                 


Ser Arg Ser Val Asn Asp Trp Val Pro Ser Ile Thr Leu Pro Glu 
145                 150                 155                 


<210>  4300
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GADD45GIP1__Homo_sapiens__NP_443082

<400>  4300

Met Ala Ala Ser Val Arg Gln Ala Arg Ser Leu Leu Gly Val Ala Ala 
1               5                   10                  15      


Thr Leu Ala Pro Gly Ser Arg Gly Tyr Arg Ala Arg Pro Pro Pro Arg 
            20                  25                  30          


Arg Arg Pro Gly Pro Arg Trp Pro Asp Pro Glu Asp Leu Leu Thr Pro 
        35                  40                  45              


Arg Trp Gln Leu Gly Pro Arg Tyr Ala Ala Lys Gln Phe Ala Arg Tyr 
    50                  55                  60                  


Gly Ala Ala Ser Gly Val Val Pro Gly Ser Leu Trp Pro Ser Pro Glu 
65                  70                  75                  80  


Gln Leu Arg Glu Leu Glu Ala Glu Glu Arg Glu Trp Tyr Pro Ser Leu 
                85                  90                  95      


Ala Thr Met Gln Glu Ser Leu Arg Val Lys Gln Leu Ala Glu Glu Gln 
            100                 105                 110         


Lys Arg Arg Glu Arg Glu Gln His Ile Ala Glu Cys Met Ala Lys Met 
        115                 120                 125             


Pro Gln Met Ile Val Asn Trp Gln Gln Gln Gln Arg Glu Asn Trp Glu 
    130                 135                 140                 


Lys Ala Gln Ala Asp Lys Glu Arg Arg Ala Arg Leu Gln Ala Glu Ala 
145                 150                 155                 160 


Gln Glu Leu Leu Gly Tyr Gln Val Asp Pro Arg Ser Ala Arg Phe Gln 
                165                 170                 175     


Glu Leu Leu Gln Asp Leu Glu Lys Lys Glu Arg Lys Arg Leu Lys Glu 
            180                 185                 190         


Glu Lys Gln Lys Arg Lys Lys Glu Ala Arg Ala Ala Ala Leu Ala Ala 
        195                 200                 205             


Ala Val Ala Gln Asp Pro Ala Ala Ser Gly Ala Pro Ser Ser 
    210                 215                 220         


<210>  4301
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GADL1__Homo_sapiens__NP_997242

<400>  4301

Met Ser Ser Asp Ser Asp Arg Gln Cys Pro Val Asp Gly Asp Ile Asp 
1               5                   10                  15      


Gln Gln Glu Met Ile Pro Ser Lys Lys Asn Ala Val Leu Val Asp Gly 
            20                  25                  30          


Val Val Leu Asn Gly Pro Thr Thr Asp Ala Lys Ala Gly Glu Lys Phe 
        35                  40                  45              


Val Glu Glu Ala Cys Arg Leu Ile Met Glu Glu Val Val Leu Lys Ala 
    50                  55                  60                  


Thr Asp Val Asn Glu Lys Val Cys Glu Trp Arg Pro Pro Glu Gln Leu 
65                  70                  75                  80  


Lys Gln Leu Leu Asp Leu Glu Met Arg Asp Ser Gly Glu Pro Pro His 
                85                  90                  95      


Lys Leu Leu Glu Leu Cys Arg Asp Val Ile His Tyr Ser Val Lys Thr 
            100                 105                 110         


Asn His Pro Arg Phe Phe Asn Gln Leu Tyr Ala Gly Leu Asp Tyr Tyr 
        115                 120                 125             


Ser Leu Val Ala Arg Phe Met Thr Glu Ala Leu Asn Pro Ser Val Tyr 
    130                 135                 140                 


Thr Tyr Glu Val Ser Pro Val Phe Leu Leu Val Glu Glu Ala Val Leu 
145                 150                 155                 160 


Lys Lys Met Ile Glu Phe Ile Gly Trp Lys Glu Gly Asp Gly Ile Phe 
                165                 170                 175     


Asn Pro Gly Gly Ser Val Ser Asn Met Tyr Ala Met Asn Leu Ala Arg 
            180                 185                 190         


Tyr Lys Tyr Cys Pro Asp Ile Lys Glu Lys Gly Leu Ser Gly Ser Pro 
        195                 200                 205             


Arg Leu Ile Leu Phe Thr Ser Ala Glu Cys His Tyr Ser Met Lys Lys 
    210                 215                 220                 


Ala Ala Ser Phe Leu Gly Ile Gly Thr Glu Asn Val Cys Phe Val Glu 
225                 230                 235                 240 


Thr Asp Gly Arg Gly Lys Met Ile Pro Glu Glu Leu Glu Lys Gln Val 
                245                 250                 255     


Trp Gln Ala Arg Lys Glu Gly Ala Ala Pro Phe Leu Val Cys Ala Thr 
            260                 265                 270         


Ser Gly Thr Thr Val Leu Gly Ala Phe Asp Pro Leu Asp Glu Ile Ala 
        275                 280                 285             


Asp Ile Cys Glu Arg His Ser Leu Trp Leu His Val Asp Ala Ser Trp 
    290                 295                 300                 


Gly Gly Ser Ala Leu Met Ser Arg Lys His Arg Lys Leu Leu His Gly 
305                 310                 315                 320 


Ile His Arg Ala Asp Ser Val Ala Trp Asn Pro His Lys Met Leu Met 
                325                 330                 335     


Ala Gly Ile Gln Cys Cys Ala Leu Leu Val Lys Asp Lys Ser Asp Leu 
            340                 345                 350         


Leu Lys Lys Cys Tyr Ser Ala Lys Ala Ser Tyr Leu Phe Gln Gln Asp 
        355                 360                 365             


Lys Phe Tyr Asp Val Ser Tyr Asp Thr Gly Asp Lys Ser Ile Gln Cys 
    370                 375                 380                 


Ser Arg Arg Pro Asp Ala Phe Lys Phe Trp Met Thr Trp Lys Ala Leu 
385                 390                 395                 400 


Gly Thr Leu Gly Leu Glu Glu Arg Val Asn Arg Ala Leu Ala Leu Ser 
                405                 410                 415     


Arg Tyr Leu Val Asp Glu Ile Lys Lys Arg Glu Gly Phe Lys Leu Leu 
            420                 425                 430         


Met Glu Pro Glu Tyr Ala Asn Ile Cys Phe Trp Tyr Ile Pro Pro Ser 
        435                 440                 445             


Leu Arg Glu Met Glu Glu Gly Pro Glu Phe Trp Ala Lys Leu Asn Leu 
    450                 455                 460                 


Val Ala Pro Ala Ile Lys Glu Arg Met Met Lys Lys Gly Ser Leu Met 
465                 470                 475                 480 


Leu Gly Tyr Gln Pro His Arg Gly Lys Val Asn Phe Phe Arg Gln Val 
                485                 490                 495     


Val Ile Ser Pro Gln Val Ser Arg Glu Asp Met Asp Phe Leu Leu Asp 
            500                 505                 510         


Glu Ile Asp Leu Leu Gly Lys Asp Met 
        515                 520     


<210>  4302
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAGE10__Homo_sapiens__NP_001091883

<400>  4302

Met Ser Trp Arg Gly Arg Ser Thr Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5                   10                  15      


Val Glu Pro Pro Glu Met Ile Gly Pro Met Leu Pro Glu Gln Phe Ser 
            20                  25                  30          


Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr Gln 
        35                  40                  45              


Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala Ser 
    50                  55                  60                  


Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Val His 
65                  70                  75                  80  


Pro Lys Thr Gly Cys Glu Cys Gly Asp Gly Pro Asp Gly Gln Glu Met 
                85                  90                  95      


Gly Leu Pro Asn Pro Glu Glu Val Lys Arg Pro Glu Glu Gly Glu Lys 
            100                 105                 110         


Gln Ser Gln Cys 
        115     


<210>  4303
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAGE1__Homo_sapiens__NP_001035753

<400>  4303

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Gly Gln Ser Gln Cys 
        115         


<210>  4304
<211>  1311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAK__Homo_sapiens__NP_005246

<400>  4304

Met Ser Leu Leu Gln Ser Ala Leu Asp Phe Leu Ala Gly Pro Gly Ser 
1               5                   10                  15      


Leu Gly Gly Ala Ser Gly Arg Asp Gln Ser Asp Phe Val Gly Gln Thr 
            20                  25                  30          


Val Glu Leu Gly Glu Leu Arg Leu Arg Val Arg Arg Val Leu Ala Glu 
        35                  40                  45              


Gly Gly Phe Ala Phe Val Tyr Glu Ala Gln Asp Val Gly Ser Gly Arg 
    50                  55                  60                  


Glu Tyr Ala Leu Lys Arg Leu Leu Ser Asn Glu Glu Glu Lys Asn Arg 
65                  70                  75                  80  


Ala Ile Ile Gln Glu Val Cys Phe Met Lys Lys Leu Ser Gly His Pro 
                85                  90                  95      


Asn Ile Val Gln Phe Cys Ser Ala Ala Ser Ile Gly Lys Glu Glu Ser 
            100                 105                 110         


Asp Thr Gly Gln Ala Glu Phe Leu Leu Leu Thr Glu Leu Cys Lys Gly 
        115                 120                 125             


Gln Leu Val Glu Phe Leu Lys Lys Met Glu Ser Arg Gly Pro Leu Ser 
    130                 135                 140                 


Cys Asp Thr Val Leu Lys Ile Phe Tyr Gln Thr Cys Arg Ala Val Gln 
145                 150                 155                 160 


His Met His Arg Gln Lys Pro Pro Ile Ile His Arg Asp Leu Lys Val 
                165                 170                 175     


Glu Asn Leu Leu Leu Ser Asn Gln Gly Thr Ile Lys Leu Cys Asp Phe 
            180                 185                 190         


Gly Ser Ala Thr Thr Ile Ser His Tyr Pro Asp Tyr Ser Trp Ser Ala 
        195                 200                 205             


Gln Arg Arg Ala Leu Val Glu Glu Glu Ile Thr Arg Asn Thr Thr Pro 
    210                 215                 220                 


Met Tyr Arg Thr Pro Glu Ile Ile Asp Leu Tyr Ser Asn Phe Pro Ile 
225                 230                 235                 240 


Gly Glu Lys Gln Asp Ile Trp Ala Leu Gly Cys Ile Leu Tyr Leu Leu 
                245                 250                 255     


Cys Phe Arg Gln His Pro Phe Glu Asp Gly Ala Lys Leu Arg Ile Val 
            260                 265                 270         


Asn Gly Lys Tyr Ser Ile Pro Pro His Asp Thr Gln Tyr Thr Val Phe 
        275                 280                 285             


His Ser Leu Ile Arg Ala Met Leu Gln Val Asn Pro Glu Glu Arg Leu 
    290                 295                 300                 


Ser Ile Ala Glu Val Val His Gln Leu Gln Glu Ile Ala Ala Ala Arg 
305                 310                 315                 320 


Asn Val Asn Pro Lys Ser Pro Ile Thr Glu Leu Leu Glu Gln Asn Gly 
                325                 330                 335     


Gly Tyr Gly Ser Ala Thr Leu Ser Arg Gly Pro Pro Pro Pro Val Gly 
            340                 345                 350         


Pro Ala Gly Ser Gly Tyr Ser Gly Gly Leu Ala Leu Ala Glu Tyr Asp 
        355                 360                 365             


Gln Pro Tyr Gly Gly Phe Leu Asp Ile Leu Arg Gly Gly Thr Glu Arg 
    370                 375                 380                 


Leu Phe Thr Asn Leu Lys Asp Thr Ser Ser Lys Val Ile Gln Ser Val 
385                 390                 395                 400 


Ala Asn Tyr Ala Lys Gly Asp Leu Asp Ile Ser Tyr Ile Thr Ser Arg 
                405                 410                 415     


Ile Ala Val Met Ser Phe Pro Ala Glu Gly Val Glu Ser Ala Leu Lys 
            420                 425                 430         


Asn Asn Ile Glu Asp Val Arg Leu Phe Leu Asp Ser Lys His Pro Gly 
        435                 440                 445             


His Tyr Ala Val Tyr Asn Leu Ser Pro Arg Thr Tyr Arg Pro Ser Arg 
    450                 455                 460                 


Phe His Asn Arg Val Ser Glu Cys Gly Trp Ala Ala Arg Arg Ala Pro 
465                 470                 475                 480 


His Leu His Thr Leu Tyr Asn Ile Cys Arg Asn Met His Ala Trp Leu 
                485                 490                 495     


Arg Gln Asp His Lys Asn Val Cys Val Val His Cys Met Asp Gly Arg 
            500                 505                 510         


Ala Ala Ser Ala Val Ala Val Cys Ser Phe Leu Cys Phe Cys Arg Leu 
        515                 520                 525             


Phe Ser Thr Ala Glu Ala Ala Val Tyr Met Phe Ser Met Lys Arg Cys 
    530                 535                 540                 


Pro Pro Gly Ile Trp Pro Ser His Lys Arg Tyr Ile Glu Tyr Met Cys 
545                 550                 555                 560 


Asp Met Val Ala Glu Glu Pro Ile Thr Pro His Ser Lys Pro Ile Leu 
                565                 570                 575     


Val Arg Ala Val Val Met Thr Pro Val Pro Leu Phe Ser Lys Gln Arg 
            580                 585                 590         


Ser Gly Cys Arg Pro Phe Cys Glu Val Tyr Val Gly Asp Glu Arg Val 
        595                 600                 605             


Ala Ser Thr Ser Gln Glu Tyr Asp Lys Met Arg Asp Phe Lys Ile Glu 
    610                 615                 620                 


Asp Gly Lys Ala Val Ile Pro Leu Gly Val Thr Val Gln Gly Asp Val 
625                 630                 635                 640 


Leu Ile Val Ile Tyr His Ala Arg Ser Thr Leu Gly Gly Arg Leu Gln 
                645                 650                 655     


Ala Lys Met Ala Ser Met Lys Met Phe Gln Ile Gln Phe His Thr Gly 
            660                 665                 670         


Phe Val Pro Arg Asn Ala Thr Thr Val Lys Phe Ala Lys Tyr Asp Leu 
        675                 680                 685             


Asp Ala Cys Asp Ile Gln Glu Lys Tyr Pro Asp Leu Phe Gln Val Asn 
    690                 695                 700                 


Leu Glu Val Glu Val Glu Pro Arg Asp Arg Pro Ser Arg Glu Ala Pro 
705                 710                 715                 720 


Pro Trp Glu Asn Ser Ser Met Arg Gly Leu Asn Pro Lys Ile Leu Phe 
                725                 730                 735     


Ser Ser Arg Glu Glu Gln Gln Asp Ile Leu Ser Lys Phe Gly Lys Pro 
            740                 745                 750         


Glu Leu Pro Arg Gln Pro Gly Ser Thr Ala Gln Tyr Asp Ala Gly Ala 
        755                 760                 765             


Gly Ser Pro Glu Ala Glu Pro Thr Asp Ser Asp Ser Pro Pro Ser Ser 
    770                 775                 780                 


Ser Ala Asp Ala Ser Arg Phe Leu His Thr Leu Asp Trp Gln Glu Glu 
785                 790                 795                 800 


Lys Glu Ala Glu Thr Gly Ala Glu Asn Ala Ser Ser Lys Glu Ser Glu 
                805                 810                 815     


Ser Ala Leu Met Glu Asp Arg Asp Glu Ser Glu Val Ser Asp Glu Gly 
            820                 825                 830         


Gly Ser Pro Ile Ser Ser Glu Gly Gln Glu Pro Arg Ala Asp Pro Glu 
        835                 840                 845             


Pro Pro Gly Leu Ala Ala Gly Leu Val Gln Gln Asp Leu Val Phe Glu 
    850                 855                 860                 


Val Glu Thr Pro Ala Val Leu Pro Glu Pro Val Pro Gln Glu Asp Gly 
865                 870                 875                 880 


Val Asp Leu Leu Gly Leu His Ser Glu Val Gly Ala Gly Pro Ala Val 
                885                 890                 895     


Pro Pro Gln Ala Cys Lys Ala Pro Ser Ser Asn Thr Asp Leu Leu Ser 
            900                 905                 910         


Cys Leu Leu Gly Pro Pro Glu Ala Ala Ser Gln Gly Pro Pro Glu Asp 
        915                 920                 925             


Leu Leu Ser Glu Asp Pro Leu Leu Leu Ala Ser Pro Ala Pro Pro Leu 
    930                 935                 940                 


Ser Val Gln Ser Thr Pro Arg Gly Gly Pro Pro Ala Ala Ala Asp Pro 
945                 950                 955                 960 


Phe Gly Pro Leu Leu Pro Ser Ser Gly Asn Asn Ser Gln Pro Cys Ser 
                965                 970                 975     


Asn Pro Asp Leu Phe Gly Glu Phe Leu Asn Ser Asp Ser Val Thr Val 
            980                 985                 990         


Pro Pro Ser Phe Pro Ser Ala His  Ser Ala Pro Pro Pro  Ser Cys Ser 
        995                 1000                 1005             


Ala Asp  Phe Leu His Leu Gly  Asp Leu Pro Gly Glu  Pro Ser Lys 
    1010                 1015                 1020             


Met Thr  Ala Ser Ser Ser Asn  Pro Asp Leu Leu Gly  Gly Trp Ala 
    1025                 1030                 1035             


Ala Trp  Thr Glu Thr Ala Ala  Ser Ala Val Ala Pro  Thr Pro Ala 
    1040                 1045                 1050             


Thr Glu  Gly Pro Leu Phe Ser  Pro Gly Gly Gln Pro  Ala Pro Cys 
    1055                 1060                 1065             


Gly Ser  Gln Ala Ser Trp Thr  Lys Ser Gln Asn Pro  Asp Pro Phe 
    1070                 1075                 1080             


Ala Asp  Leu Gly Asp Leu Ser  Ser Gly Leu Gln Gly  Ser Pro Ala 
    1085                 1090                 1095             


Gly Phe  Pro Pro Gly Gly Phe  Ile Pro Lys Thr Ala  Thr Thr Pro 
    1100                 1105                 1110             


Lys Gly  Ser Ser Ser Trp Gln  Thr Ser Arg Pro Pro  Ala Gln Gly 
    1115                 1120                 1125             


Ala Ser  Trp Pro Pro Gln Ala  Lys Pro Pro Pro Lys  Ala Cys Thr 
    1130                 1135                 1140             


Gln Pro  Arg Pro Asn Tyr Ala  Ser Asn Phe Ser Val  Ile Gly Ala 
    1145                 1150                 1155             


Arg Glu  Glu Arg Gly Val Arg  Ala Pro Ser Phe Ala  Gln Lys Pro 
    1160                 1165                 1170             


Lys Val  Ser Glu Asn Asp Phe  Glu Asp Leu Leu Ser  Asn Gln Gly 
    1175                 1180                 1185             


Phe Ser  Ser Arg Ser Asp Lys  Lys Gly Pro Lys Thr  Ile Ala Glu 
    1190                 1195                 1200             


Met Arg  Lys Gln Asp Leu Ala  Lys Asp Thr Asp Pro  Leu Lys Leu 
    1205                 1210                 1215             


Lys Leu  Leu Asp Trp Ile Glu  Gly Lys Glu Arg Asn  Ile Arg Ala 
    1220                 1225                 1230             


Leu Leu  Ser Thr Leu His Thr  Val Leu Trp Asp Gly  Glu Ser Arg 
    1235                 1240                 1245             


Trp Thr  Pro Val Gly Met Ala  Asp Leu Val Ala Pro  Glu Gln Val 
    1250                 1255                 1260             


Lys Lys  His Tyr Arg Arg Ala  Val Leu Ala Val His  Pro Asp Lys 
    1265                 1270                 1275             


Ala Ala  Gly Gln Pro Tyr Glu  Gln His Ala Lys Met  Ile Phe Met 
    1280                 1285                 1290             


Glu Leu  Asn Asp Ala Trp Ser  Glu Phe Glu Asn Gln  Gly Ser Arg 
    1295                 1300                 1305             


Pro Leu  Phe 
    1310     


<210>  4305
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALC__Homo_sapiens__NP_000144

<400>  4305

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
    210                 215                 220                 


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
225                 230                 235                 240 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
                245                 250                 255     


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
            260                 265                 270         


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
        275                 280                 285             


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
    290                 295                 300                 


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
305                 310                 315                 320 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
                325                 330                 335     


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
            340                 345                 350         


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
        355                 360                 365             


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
    370                 375                 380                 


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
385                 390                 395                 400 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
                405                 410                 415     


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
            420                 425                 430         


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
    450                 455                 460                 


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
465                 470                 475                 480 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
                485                 490                 495     


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
            500                 505                 510         


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
        515                 520                 525             


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
    530                 535                 540                 


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
545                 550                 555                 560 


Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
                565                 570                 575     


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
            580                 585                 590         


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
        595                 600                 605             


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
    610                 615                 620                 


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
625                 630                 635                 640 


Thr Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
                645                 650                 655     


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
            660                 665                 670         


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
        675                 680                 685 


<210>  4306
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAL__Homo_sapiens__NP_057057

<400>  4306

Met Ala Arg Gly Ser Ala Leu Leu Leu Ala Ser Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Ser Ala Ser Ala Gly Leu Trp Ser Pro Ala Lys Glu Lys Arg 
            20                  25                  30          


Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 
        35                  40                  45              


Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr Ser Lys Arg 
    50                  55                  60                  


Glu Leu Arg Pro Glu Asp Asp Met Lys Pro Gly Ser Phe Asp Arg Ser 
65                  70                  75                  80  


Ile Pro Glu Asn Asn Ile Met Arg Thr Ile Ile Glu Phe Leu Ser Phe 
                85                  90                  95      


Leu His Leu Lys Glu Ala Gly Ala Leu Asp Arg Leu Leu Asp Leu Pro 
            100                 105                 110         


Ala Ala Ala Ser Ser Glu Asp Ile Glu Arg Ser 
        115                 120             


<210>  4307
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALK1__Homo_sapiens__NP_000145

<400>  4307

Met Ala Ala Leu Arg Gln Pro Gln Val Ala Glu Leu Leu Ala Glu Ala 
1               5                   10                  15      


Arg Arg Ala Phe Arg Glu Glu Phe Gly Ala Glu Pro Glu Leu Ala Val 
            20                  25                  30          


Ser Ala Pro Gly Arg Val Asn Leu Ile Gly Glu His Thr Asp Tyr Asn 
        35                  40                  45              


Gln Gly Leu Val Leu Pro Met Ala Leu Glu Leu Met Thr Val Leu Val 
    50                  55                  60                  


Gly Ser Pro Arg Lys Asp Gly Leu Val Ser Leu Leu Thr Thr Ser Glu 
65                  70                  75                  80  


Gly Ala Asp Glu Pro Gln Arg Leu Gln Phe Pro Leu Pro Thr Ala Gln 
                85                  90                  95      


Arg Ser Leu Glu Pro Gly Thr Pro Arg Trp Ala Asn Tyr Val Lys Gly 
            100                 105                 110         


Val Ile Gln Tyr Tyr Pro Ala Ala Pro Leu Pro Gly Phe Ser Ala Val 
        115                 120                 125             


Val Val Ser Ser Val Pro Leu Gly Gly Gly Leu Ser Ser Ser Ala Ser 
    130                 135                 140                 


Leu Glu Val Ala Thr Tyr Thr Phe Leu Gln Gln Leu Cys Pro Asp Ser 
145                 150                 155                 160 


Gly Thr Ile Ala Ala Arg Ala Gln Val Cys Gln Gln Ala Glu His Ser 
                165                 170                 175     


Phe Ala Gly Met Pro Cys Gly Ile Met Asp Gln Phe Ile Ser Leu Met 
            180                 185                 190         


Gly Gln Lys Gly His Ala Leu Leu Ile Asp Cys Arg Ser Leu Glu Thr 
        195                 200                 205             


Ser Leu Val Pro Leu Ser Asp Pro Lys Leu Ala Val Leu Ile Thr Asn 
    210                 215                 220                 


Ser Asn Val Arg His Ser Leu Ala Ser Ser Glu Tyr Pro Val Arg Arg 
225                 230                 235                 240 


Arg Gln Cys Glu Glu Val Ala Arg Ala Leu Gly Lys Glu Ser Leu Arg 
                245                 250                 255     


Glu Val Gln Leu Glu Glu Leu Glu Ala Ala Arg Asp Leu Val Ser Lys 
            260                 265                 270         


Glu Gly Phe Arg Arg Ala Arg His Val Val Gly Glu Ile Arg Arg Thr 
        275                 280                 285             


Ala Gln Ala Ala Ala Ala Leu Arg Arg Gly Asp Tyr Arg Ala Phe Gly 
    290                 295                 300                 


Arg Leu Met Val Glu Ser His Arg Ser Leu Arg Asp Asp Tyr Glu Val 
305                 310                 315                 320 


Ser Cys Pro Glu Leu Asp Gln Leu Val Glu Ala Ala Leu Ala Val Pro 
                325                 330                 335     


Gly Val Tyr Gly Ser Arg Met Thr Gly Gly Gly Phe Gly Gly Cys Thr 
            340                 345                 350         


Val Thr Leu Leu Glu Ala Ser Ala Ala Pro His Ala Met Arg His Ile 
        355                 360                 365             


Gln Glu His Tyr Gly Gly Thr Ala Thr Phe Tyr Leu Ser Gln Ala Ala 
    370                 375                 380                 


Asp Gly Ala Lys Val Leu Cys Leu 
385                 390         


<210>  4308
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALK2__Homo_sapiens__NP_001001556

<400>  4308

Met Pro Val Leu Tyr Asp Arg Leu Leu Lys Leu Lys Glu Met Phe Asn 
1               5                   10                  15      


Ser Lys Phe Gly Ser Ile Pro Lys Phe Tyr Val Arg Ala Pro Gly Arg 
            20                  25                  30          


Val Asn Ile Ile Gly Glu His Ile Asp Tyr Cys Gly Tyr Ser Val Leu 
        35                  40                  45              


Pro Met Ala Val Glu Gln Asp Val Leu Ile Ala Val Glu Pro Val Lys 
    50                  55                  60                  


Thr Tyr Ala Leu Gln Leu Ala Asn Thr Asn Pro Leu Tyr Pro Asp Phe 
65                  70                  75                  80  


Ser Thr Ser Ala Asn Asn Ile Gln Ile Asp Lys Thr Lys Pro Leu Trp 
                85                  90                  95      


His Asn Tyr Phe Leu Cys Gly Leu Lys Gly Ile Gln Glu His Phe Gly 
            100                 105                 110         


Leu Ser Asn Leu Thr Gly Met Asn Cys Leu Val Asp Gly Asn Ile Pro 
        115                 120                 125             


Pro Ser Ser Gly Leu Ser Ser Ser Ser Ala Leu Val Cys Cys Ala Gly 
    130                 135                 140                 


Leu Val Thr Leu Thr Val Leu Gly Arg Asn Leu Ser Lys Val Glu Leu 
145                 150                 155                 160 


Ala Glu Ile Cys Ala Lys Ser Glu Arg Tyr Ile Gly Thr Glu Gly Gly 
                165                 170                 175     


Gly Met Asp Gln Ser Ile Ser Phe Leu Ala Glu Glu Gly Thr Ala Lys 
            180                 185                 190         


Leu Ile Glu Phe Ser Pro Leu Arg Ala Thr Asp Val Lys Leu Pro Ser 
        195                 200                 205             


Gly Ala Val Phe Val Ile Ala Asn Ser Cys Val Glu Met Asn Lys Ala 
    210                 215                 220                 


Ala Thr Ser His Phe Asn Ile Arg Val Met Glu Cys Arg Leu Ala Ala 
225                 230                 235                 240 


Lys Leu Leu Ala Lys Tyr Lys Ser Leu Gln Trp Asp Lys Val Leu Arg 
                245                 250                 255     


Leu Glu Glu Val Gln Ala Lys Leu Gly Ile Ser Leu Glu Glu Met Leu 
            260                 265                 270         


Leu Val Thr Glu Asp Ala Leu His Pro Glu Pro Tyr Asn Pro Glu Glu 
        275                 280                 285             


Ile Cys Arg Cys Leu Gly Ile Ser Leu Glu Glu Leu Arg Thr Gln Ile 
    290                 295                 300                 


Leu Ser Pro Asn Thr Gln Asp Val Leu Ile Phe Lys Leu Tyr Gln Arg 
305                 310                 315                 320 


Ala Lys His Val Tyr Ser Glu Ala Ala Arg Val Leu Gln Phe Lys Lys 
                325                 330                 335     


Ile Cys Glu Glu Ala Pro Glu Asn Met Val Gln Leu Leu Gly Glu Leu 
            340                 345                 350         


Met Asn Gln Ser His Met Ser Cys Arg Asp Met Tyr Glu Cys Ser Cys 
        355                 360                 365             


Pro Glu Leu Asp Gln Leu Val Asp Ile Cys Arg Lys Phe Gly Ala Gln 
    370                 375                 380                 


Gly Ser Arg Leu Thr Gly Ala Gly Trp Gly Gly Cys Thr Val Ser Met 
385                 390                 395                 400 


Val Pro Ala Asp Lys Leu Pro Ser Phe Leu Ala Asn Val His Lys Ala 
                405                 410                 415     


Tyr Tyr Gln Arg Ser Asp Gly Ser Leu Ala Pro Glu Lys Gln Ser Leu 
            420                 425                 430         


Phe Ala Thr Lys Pro Gly Gly Gly Ala Leu Val Leu Leu Glu Ala 
        435                 440                 445         


<210>  4309
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALM__Homo_sapiens__NP_620156

<400>  4309

Met Ala Ser Val Thr Arg Ala Val Phe Gly Glu Leu Pro Ser Gly Gly 
1               5                   10                  15      


Gly Thr Val Glu Lys Phe Gln Leu Gln Ser Asp Leu Leu Arg Val Asp 
            20                  25                  30          


Ile Ile Ser Trp Gly Cys Thr Ile Thr Ala Leu Glu Val Lys Asp Arg 
        35                  40                  45              


Gln Gly Arg Ala Ser Asp Val Val Leu Gly Phe Ala Glu Leu Glu Gly 
    50                  55                  60                  


Tyr Leu Gln Lys Gln Pro Tyr Phe Gly Ala Val Ile Gly Arg Val Ala 
65                  70                  75                  80  


Asn Arg Ile Ala Lys Gly Thr Phe Lys Val Asp Gly Lys Glu Tyr His 
                85                  90                  95      


Leu Ala Ile Asn Lys Glu Pro Asn Ser Leu His Gly Gly Val Arg Gly 
            100                 105                 110         


Phe Asp Lys Val Leu Trp Thr Pro Arg Val Leu Ser Asn Gly Val Gln 
        115                 120                 125             


Phe Ser Arg Ile Ser Pro Asp Gly Glu Glu Gly Tyr Pro Gly Glu Leu 
    130                 135                 140                 


Lys Val Trp Val Thr Tyr Thr Leu Asp Gly Gly Glu Leu Ile Val Asn 
145                 150                 155                 160 


Tyr Arg Ala Gln Ala Ser Gln Ala Thr Pro Val Asn Leu Thr Asn His 
                165                 170                 175     


Ser Tyr Phe Asn Leu Ala Gly Gln Ala Ser Pro Asn Ile Asn Asp His 
            180                 185                 190         


Glu Val Thr Ile Glu Ala Asp Thr Tyr Leu Pro Val Asp Glu Thr Leu 
        195                 200                 205             


Ile Pro Thr Gly Glu Val Ala Pro Val Gln Gly Thr Ala Phe Asp Leu 
    210                 215                 220                 


Arg Lys Pro Val Glu Leu Gly Lys His Leu Gln Asp Phe His Leu Asn 
225                 230                 235                 240 


Gly Phe Asp His Asn Phe Cys Leu Lys Gly Ser Lys Glu Lys His Phe 
                245                 250                 255     


Cys Ala Arg Val His His Ala Ala Ser Gly Arg Val Leu Glu Val Tyr 
            260                 265                 270         


Thr Thr Gln Pro Gly Val Gln Phe Tyr Thr Gly Asn Phe Leu Asp Gly 
        275                 280                 285             


Thr Leu Lys Gly Lys Asn Gly Ala Val Tyr Pro Lys His Ser Gly Phe 
    290                 295                 300                 


Cys Leu Glu Thr Gln Asn Trp Pro Asp Ala Val Asn Gln Pro Arg Phe 
305                 310                 315                 320 


Pro Pro Val Leu Leu Arg Pro Gly Glu Glu Tyr Asp His Thr Thr Trp 
                325                 330                 335     


Phe Lys Phe Ser Val Ala 
            340         


<210>  4310
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNS__Homo_sapiens__NP_000503

<400>  4310

Met Ala Ala Val Val Ala Ala Thr Arg Trp Trp Gln Leu Leu Leu Val 
1               5                   10                  15      


Leu Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn 
            20                  25                  30          


Ile Leu Leu Leu Leu Met Asp Asp Met Gly Trp Gly Asp Leu Gly Val 
        35                  40                  45              


Tyr Gly Glu Pro Ser Arg Glu Thr Pro Asn Leu Asp Arg Met Ala Ala 
    50                  55                  60                  


Glu Gly Leu Leu Phe Pro Asn Phe Tyr Ser Ala Asn Pro Leu Cys Ser 
65                  70                  75                  80  


Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg Leu Pro Ile Arg Asn Gly 
                85                  90                  95      


Phe Tyr Thr Thr Asn Ala His Ala Arg Asn Ala Tyr Thr Pro Gln Glu 
            100                 105                 110         


Ile Val Gly Gly Ile Pro Asp Ser Glu Gln Leu Leu Pro Glu Leu Leu 
        115                 120                 125             


Lys Lys Ala Gly Tyr Val Ser Lys Ile Val Gly Lys Trp His Leu Gly 
    130                 135                 140                 


His Arg Pro Gln Phe His Pro Leu Lys His Gly Phe Asp Glu Trp Phe 
145                 150                 155                 160 


Gly Ser Pro Asn Cys His Phe Gly Pro Tyr Asp Asn Lys Ala Arg Pro 
                165                 170                 175     


Asn Ile Pro Val Tyr Arg Asp Trp Glu Met Val Gly Arg Tyr Tyr Glu 
            180                 185                 190         


Glu Phe Pro Ile Asn Leu Lys Thr Gly Glu Ala Asn Leu Thr Gln Ile 
        195                 200                 205             


Tyr Leu Gln Glu Ala Leu Asp Phe Ile Lys Arg Gln Ala Arg His His 
    210                 215                 220                 


Pro Phe Phe Leu Tyr Trp Ala Val Asp Ala Thr His Ala Pro Val Tyr 
225                 230                 235                 240 


Ala Ser Lys Pro Phe Leu Gly Thr Ser Gln Arg Gly Arg Tyr Gly Asp 
                245                 250                 255     


Ala Val Arg Glu Ile Asp Asp Ser Ile Gly Lys Ile Leu Glu Leu Leu 
            260                 265                 270         


Gln Asp Leu His Val Ala Asp Asn Thr Phe Val Phe Phe Thr Ser Asp 
        275                 280                 285             


Asn Gly Ala Ala Leu Ile Ser Ala Pro Glu Gln Gly Gly Ser Asn Gly 
    290                 295                 300                 


Pro Phe Leu Cys Gly Lys Gln Thr Thr Phe Glu Gly Gly Met Arg Glu 
305                 310                 315                 320 


Pro Ala Leu Ala Trp Trp Pro Gly His Val Thr Ala Gly Gln Val Ser 
                325                 330                 335     


His Gln Leu Gly Ser Ile Met Asp Leu Phe Thr Thr Ser Leu Ala Leu 
            340                 345                 350         


Ala Gly Leu Thr Pro Pro Ser Asp Arg Ala Ile Asp Gly Leu Asn Leu 
        355                 360                 365             


Leu Pro Thr Leu Leu Gln Gly Arg Leu Met Asp Arg Pro Ile Phe Tyr 
    370                 375                 380                 


Tyr Arg Gly Asp Thr Leu Met Ala Ala Thr Leu Gly Gln His Lys Ala 
385                 390                 395                 400 


His Phe Trp Thr Trp Thr Asn Ser Trp Glu Asn Phe Arg Gln Gly Ile 
                405                 410                 415     


Asp Phe Cys Pro Gly Gln Asn Val Ser Gly Val Thr Thr His Asn Leu 
            420                 425                 430         


Glu Asp His Thr Lys Leu Pro Leu Ile Phe His Leu Gly Arg Asp Pro 
        435                 440                 445             


Gly Glu Arg Phe Pro Leu Ser Phe Ala Ser Ala Glu Tyr Gln Glu Ala 
    450                 455                 460                 


Leu Ser Arg Ile Thr Ser Val Val Gln Gln His Gln Glu Ala Leu Val 
465                 470                 475                 480 


Pro Ala Gln Pro Gln Leu Asn Val Cys Asn Trp Ala Val Met Asn Trp 
                485                 490                 495     


Ala Pro Pro Gly Cys Glu Lys Leu Gly Lys Cys Leu Thr Pro Pro Glu 
            500                 505                 510         


Ser Ile Pro Lys Lys Cys Leu Trp Ser His 
        515                 520         


<210>  4311
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT12__Homo_sapiens__NP_078918

<400>  4311

Met Trp Gly Arg Thr Ala Arg Arg Arg Cys Pro Arg Glu Leu Arg Arg 
1               5                   10                  15      


Gly Arg Glu Ala Leu Leu Val Leu Leu Ala Leu Leu Ala Leu Ala Gly 
            20                  25                  30          


Leu Gly Ser Val Leu Arg Ala Gln Arg Gly Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Glu Pro Gly Pro Pro Arg Thr Pro Arg Pro Gly Arg Arg Glu Pro Val 
    50                  55                  60                  


Met Pro Arg Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu 
65                  70                  75                  80  


Ala Val Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu 
                85                  90                  95      


Ser Val Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser 
            100                 105                 110         


Leu His Arg Arg Leu Pro Glu Arg Trp Asn Pro Leu Cys Lys Glu Lys 
        115                 120                 125             


Lys Tyr Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe 
    130                 135                 140                 


Tyr Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu 
145                 150                 155                 160 


Glu Thr Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser 
            180                 185                 190         


Gly Leu Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu 
        195                 200                 205             


Val Arg Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu 
    210                 215                 220                 


Thr Phe Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro 
225                 230                 235                 240 


Leu Leu Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val 
                245                 250                 255     


Ile Asp Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly 
            260                 265                 270         


Glu Pro Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Thr Trp His 
        275                 280                 285             


Thr Val Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val 
    290                 295                 300                 


Ile Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys 
305                 310                 315                 320 


Tyr Phe Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly 
                325                 330                 335     


Gly Glu Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val 
            340                 345                 350         


Leu Glu Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln 
        355                 360                 365             


Ala Pro Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala 
    370                 375                 380                 


Glu Val Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro 
385                 390                 395                 400 


Arg Ala Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu 
                405                 410                 415     


Arg Asp Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val 
            420                 425                 430         


Tyr Pro Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met 
        435                 440                 445             


Leu Gln Asn Lys Gly Leu Thr Asp Tyr Cys Phe Asp Tyr Asn Pro Pro 
    450                 455                 460                 


Asp Glu Asn Gln Ile Val Gly His Gln Val Ile Leu Tyr Leu Cys His 
465                 470                 475                 480 


Gly Met Gly Gln Asn Gln Phe Phe Glu Tyr Thr Ser Gln Lys Glu Ile 
                485                 490                 495     


Arg Tyr Asn Thr His Gln Pro Glu Gly Cys Ile Ala Val Glu Ala Gly 
            500                 505                 510         


Met Asp Thr Leu Ile Met His Leu Cys Glu Glu Thr Ala Pro Glu Asn 
        515                 520                 525             


Gln Lys Phe Ile Leu Gln Glu Asp Gly Ser Leu Phe His Glu Gln Ser 
    530                 535                 540                 


Lys Lys Cys Val Gln Ala Ala Arg Lys Glu Ser Ser Asp Ser Phe Val 
545                 550                 555                 560 


Pro Leu Leu Arg Asp Cys Thr Asn Ser Asp His Gln Lys Trp Phe Phe 
                565                 570                 575     


Lys Glu Arg Met Leu 
            580     


<210>  4312
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT13__Homo_sapiens__NP_001288556

<400>  4312

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn 
    450                 455                 460                 


Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu 
465                 470                 475                 480 


Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys 
                485                 490                 495     


His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Ser Cys 
            500                 505                 510         


Leu Ser Val Asn Lys Val Ala Asp Gly Ser Gln His Pro Thr Val Glu 
        515                 520                 525             


Thr Cys Asn Asp Ser Thr Leu Gln Lys Trp Leu Leu Arg Asn Tyr Thr 
    530                 535                 540                 


Arg Met Glu Ile Phe Arg Asn Ile Phe Gly Asn Ser Thr Asp Tyr Ile 
545                 550                 555                 560 


Leu 
    


<210>  4313
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT14__Homo_sapiens__NP_001240755

<400>  4313

Met Arg Arg Leu Thr Arg Arg Leu Val Leu Pro Val Phe Gly Val Leu 
1               5                   10                  15      


Trp Ile Thr Val Leu Leu Phe Phe Trp Val Thr Lys Arg Lys Leu Glu 
            20                  25                  30          


Val Pro Thr Gly Pro Glu Val Gln Thr Pro Lys Val Trp Ser Leu Phe 
        35                  40                  45              


Phe Lys Val Ala Gly Met Ser Pro Trp Ala Pro Gln Val Pro Val Ser 
    50                  55                  60                  


Pro Thr Pro Pro Tyr Gln Arg Gly His Leu Pro Thr Gly Gly His Leu 
65                  70                  75                  80  


Ala Val Cys His Phe Pro Cys Leu Leu Gln Glu Ala Gln Phe His Leu 
                85                  90                  95      


Gln Thr Gln Val Phe Leu Gln Val Arg Cys Thr Leu Leu Val Tyr Cys 
            100                 105                 110         


Thr Asp Leu Pro Pro Thr Ser Ile Ile Ile Thr Phe His Asn Glu Ala 
        115                 120                 125             


Arg Ser Thr Leu Leu Arg Thr Ile Arg Ser Val Leu Asn Arg Thr Pro 
    130                 135                 140                 


Thr His Leu Ile Arg Glu Ile Ile Leu Val Asp Asp Phe Ser Asn Asp 
145                 150                 155                 160 


Pro Asp Asp Cys Lys Gln Leu Ile Lys Leu Pro Lys Val Lys Cys Leu 
                165                 170                 175     


Arg Asn Asn Glu Arg Gln Gly Leu Val Arg Ser Arg Ile Arg Gly Ala 
            180                 185                 190         


Asp Ile Ala Gln Gly Thr Thr Leu Thr Phe Leu Asp Ser His Cys Glu 
        195                 200                 205             


Val Asn Arg Asp Trp Leu Gln Pro Leu Leu His Arg Val Lys Glu Asp 
    210                 215                 220                 


Tyr Thr Arg Val Val Cys Pro Val Ile Asp Ile Ile Asn Leu Asp Thr 
225                 230                 235                 240 


Phe Thr Tyr Ile Glu Ser Ala Ser Glu Leu Arg Gly Gly Phe Asp Trp 
                245                 250                 255     


Ser Leu His Phe Gln Trp Glu Gln Leu Ser Pro Glu Gln Lys Ala Arg 
            260                 265                 270         


Arg Leu Asp Pro Thr Glu Pro Ile Arg Thr Pro Ile Ile Ala Gly Gly 
        275                 280                 285             


Leu Phe Val Ile Asp Lys Ala Trp Phe Asp Tyr Leu Gly Lys Tyr Asp 
    290                 295                 300                 


Met Asp Met Asp Ile Trp Gly Gly Glu Asn Phe Glu Ile Ser Phe Arg 
305                 310                 315                 320 


Val Trp Met Cys Gly Gly Ser Leu Glu Ile Val Pro Cys Ser Arg Val 
                325                 330                 335     


Gly His Val Phe Arg Lys Lys His Pro Tyr Val Phe Pro Asp Gly Asn 
            340                 345                 350         


Ala Asn Thr Tyr Ile Lys Asn Thr Lys Arg Thr Ala Glu Val Trp Met 
        355                 360                 365             


Asp Glu Tyr Lys Gln Tyr Tyr Tyr Ala Ala Arg Pro Phe Ala Leu Glu 
    370                 375                 380                 


Arg Pro Phe Gly Asn Val Glu Ser Arg Leu Asp Leu Arg Lys Asn Leu 
385                 390                 395                 400 


Arg Cys Gln Ser Phe Lys Trp Tyr Leu Glu Asn Ile Tyr Pro Glu Leu 
                405                 410                 415     


Ser Ile Pro Lys Glu Ser Ser Ile Gln Lys Gly Asn Ile Arg Gln Arg 
            420                 425                 430         


Gln Lys Cys Leu Glu Ser Gln Arg Gln Asn Asn Gln Glu Thr Pro Asn 
        435                 440                 445             


Leu Lys Leu Ser Pro Cys Ala Lys Val Lys Gly Glu Asp Ala Lys Ser 
    450                 455                 460                 


Gln Val Trp Ala Phe Thr Tyr Thr Gln Gln Ile Leu Gln Glu Glu Leu 
465                 470                 475                 480 


Cys Leu Ser Val Ile Thr Leu Phe Pro Gly Ala Pro Val Val Leu Val 
                485                 490                 495     


Leu Cys Lys Asn Gly Asp Asp Arg Gln Gln Trp Thr Lys Thr Gly Ser 
            500                 505                 510         


His Ile Glu His Ile Ala Ser His Leu Cys Leu Asp Thr Asp Met Phe 
        515                 520                 525             


Gly Asp Gly Thr Glu Asn Gly Lys Glu Ile Val Val Asn Pro Cys Glu 
    530                 535                 540                 


Ser Ser Leu Met Ser Gln His Trp Asp Met Val Ser Ser 
545                 550                 555         


<210>  4314
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT15__Homo_sapiens__NP_473451

<400>  4314

Met Leu Leu Arg Lys Arg Tyr Arg His Arg Pro Cys Arg Leu Gln Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Met Leu Gly Cys Val Leu Met Met Val Ala Met 
            20                  25                  30          


Leu His Pro Pro His His Thr Leu His Gln Thr Val Thr Ala Gln Ala 
        35                  40                  45              


Ser Lys His Ser Pro Glu Ala Arg Tyr Arg Leu Asp Phe Gly Glu Ser 
    50                  55                  60                  


Gln Asp Trp Val Leu Glu Ala Glu Asp Glu Gly Glu Glu Tyr Ser Pro 
65                  70                  75                  80  


Leu Glu Gly Leu Pro Pro Phe Ile Ser Leu Arg Glu Asp Gln Leu Leu 
                85                  90                  95      


Val Ala Val Ala Leu Pro Gln Ala Arg Arg Asn Gln Ser Gln Gly Arg 
            100                 105                 110         


Arg Gly Gly Ser Tyr Arg Leu Ile Lys Gln Pro Arg Arg Gln Asp Lys 
        115                 120                 125             


Glu Ala Pro Lys Arg Asp Trp Gly Ala Asp Glu Asp Gly Glu Val Ser 
    130                 135                 140                 


Glu Glu Glu Glu Leu Thr Pro Phe Ser Leu Asp Pro Arg Gly Leu Gln 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Arg Ile Pro Leu Gln Arg Ala Leu Pro Glu Val 
                165                 170                 175     


Arg His Pro Leu Cys Leu Gln Gln His Pro Gln Asp Ser Leu Pro Thr 
            180                 185                 190         


Ala Ser Val Ile Leu Cys Phe His Asp Glu Ala Trp Ser Thr Leu Leu 
        195                 200                 205             


Arg Thr Val His Ser Ile Leu Asp Thr Val Pro Arg Ala Phe Leu Lys 
    210                 215                 220                 


Glu Ile Ile Leu Val Asp Asp Leu Ser Gln Gln Gly Gln Leu Lys Ser 
225                 230                 235                 240 


Ala Leu Ser Glu Tyr Val Ala Arg Leu Glu Gly Val Lys Leu Leu Arg 
                245                 250                 255     


Ser Asn Lys Arg Leu Gly Ala Ile Arg Ala Arg Met Leu Gly Ala Thr 
            260                 265                 270         


Arg Ala Thr Gly Asp Val Leu Val Phe Met Asp Ala His Cys Glu Cys 
        275                 280                 285             


His Pro Gly Trp Leu Glu Pro Leu Leu Ser Arg Ile Ala Gly Asp Arg 
    290                 295                 300                 


Ser Arg Val Val Ser Pro Val Ile Asp Val Ile Asp Trp Lys Thr Phe 
305                 310                 315                 320 


Gln Tyr Tyr Pro Ser Lys Asp Leu Gln Arg Gly Val Leu Asp Trp Lys 
                325                 330                 335     


Leu Asp Phe His Trp Glu Pro Leu Pro Glu His Val Arg Lys Ala Leu 
            340                 345                 350         


Gln Ser Pro Ile Ser Pro Ile Arg Ser Pro Val Val Pro Gly Glu Val 
        355                 360                 365             


Val Ala Met Asp Arg His Tyr Phe Gln Asn Thr Gly Ala Tyr Asp Ser 
    370                 375                 380                 


Leu Met Ser Leu Arg Gly Gly Glu Asn Leu Glu Leu Ser Phe Lys Ala 
385                 390                 395                 400 


Trp Leu Cys Gly Gly Ser Val Glu Ile Leu Pro Cys Ser Arg Val Gly 
                405                 410                 415     


His Ile Tyr Gln Asn Gln Asp Ser His Ser Pro Leu Asp Gln Glu Ala 
            420                 425                 430         


Thr Leu Arg Asn Arg Val Arg Ile Ala Glu Thr Trp Leu Gly Ser Phe 
        435                 440                 445             


Lys Glu Thr Phe Tyr Lys His Ser Pro Glu Ala Phe Ser Leu Ser Lys 
    450                 455                 460                 


Ala Glu Lys Pro Asp Cys Met Glu Arg Leu Gln Leu Gln Arg Arg Leu 
465                 470                 475                 480 


Gly Cys Arg Thr Phe His Trp Phe Leu Ala Asn Val Tyr Pro Glu Leu 
                485                 490                 495     


Tyr Pro Ser Glu Pro Arg Pro Ser Phe Ser Gly Lys Leu His Asn Thr 
            500                 505                 510         


Gly Leu Gly Leu Cys Ala Asp Cys Gln Ala Glu Gly Asp Ile Leu Gly 
        515                 520                 525             


Cys Pro Met Val Leu Ala Pro Cys Ser Asp Ser Arg Gln Gln Gln Tyr 
    530                 535                 540                 


Leu Gln His Thr Ser Arg Lys Glu Ile His Phe Gly Ser Pro Gln His 
545                 550                 555                 560 


Leu Cys Phe Ala Val Arg Gln Glu Gln Val Ile Leu Gln Asn Cys Thr 
                565                 570                 575     


Glu Glu Gly Leu Ala Ile His Gln Gln His Trp Asp Phe Gln Glu Asn 
            580                 585                 590         


Gly Met Ile Val His Ile Leu Ser Gly Lys Cys Met Glu Ala Val Val 
        595                 600                 605             


Gln Glu Asn Asn Lys Asp Leu Tyr Leu Arg Pro Cys Asp Gly Lys Ala 
    610                 615                 620                 


Arg Gln Gln Trp Arg Phe Asp Gln Ile Asn Ala Val Asp Glu Arg 
625                 630                 635                 


<210>  4315
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT18__Homo_sapiens__NP_940918

<400>  4315

Met Val Cys Thr Arg Lys Thr Lys Thr Leu Val Ser Thr Cys Val Ile 
1               5                   10                  15      


Leu Ser Gly Met Thr Asn Ile Ile Cys Leu Leu Tyr Val Gly Trp Val 
            20                  25                  30          


Thr Asn Tyr Ile Ala Ser Val Tyr Val Arg Gly Gln Glu Pro Ala Pro 
        35                  40                  45              


Asp Lys Lys Leu Glu Glu Asp Lys Gly Asp Thr Leu Lys Ile Ile Glu 
    50                  55                  60                  


Arg Leu Asp His Leu Glu Asn Val Ile Lys Gln His Ile Gln Glu Ala 
65                  70                  75                  80  


Pro Ala Lys Pro Glu Glu Ala Glu Ala Glu Pro Phe Thr Asp Ser Ser 
                85                  90                  95      


Leu Phe Ala His Trp Gly Gln Glu Leu Ser Pro Glu Gly Arg Arg Val 
            100                 105                 110         


Ala Leu Lys Gln Phe Gln Tyr Tyr Gly Tyr Asn Ala Tyr Leu Ser Asp 
        115                 120                 125             


Arg Leu Pro Leu Asp Arg Pro Leu Pro Asp Leu Arg Pro Ser Gly Cys 
    130                 135                 140                 


Arg Asn Leu Ser Phe Pro Asp Ser Leu Pro Glu Val Ser Ile Val Phe 
145                 150                 155                 160 


Ile Phe Val Asn Glu Ala Leu Ser Val Leu Leu Arg Ser Ile His Ser 
                165                 170                 175     


Ala Met Glu Arg Thr Pro Pro His Leu Leu Lys Glu Ile Ile Leu Val 
            180                 185                 190         


Asp Asp Asn Ser Ser Asn Glu Glu Leu Lys Glu Lys Leu Thr Glu Tyr 
        195                 200                 205             


Val Asp Lys Val Asn Ser Gln Lys Pro Gly Phe Ile Lys Val Val Arg 
    210                 215                 220                 


His Ser Lys Gln Glu Gly Leu Ile Arg Ser Arg Val Ser Gly Trp Arg 
225                 230                 235                 240 


Ala Ala Thr Ala Pro Val Val Ala Leu Phe Asp Ala His Val Glu Phe 
                245                 250                 255     


Asn Val Gly Trp Ala Glu Pro Val Leu Thr Arg Ile Lys Glu Asn Arg 
            260                 265                 270         


Lys Arg Ile Ile Ser Pro Ser Phe Asp Asn Ile Lys Tyr Asp Asn Phe 
        275                 280                 285             


Glu Ile Glu Glu Tyr Pro Leu Ala Ala Gln Gly Phe Asp Trp Glu Leu 
    290                 295                 300                 


Trp Cys Arg Tyr Leu Asn Pro Pro Lys Ala Trp Trp Lys Leu Glu Asn 
305                 310                 315                 320 


Ser Thr Ala Pro Ile Arg Ser Pro Ala Leu Ile Gly Cys Phe Ile Val 
                325                 330                 335     


Asp Arg Gln Tyr Phe Gln Glu Ile Gly Leu Leu Asp Glu Gly Met Glu 
            340                 345                 350         


Val Tyr Gly Gly Glu Asn Val Glu Leu Gly Ile Arg Val Trp Gln Cys 
        355                 360                 365             


Gly Gly Ser Val Glu Val Leu Pro Cys Ser Arg Ile Ala His Ile Glu 
    370                 375                 380                 


Arg Ala His Lys Pro Tyr Thr Glu Asp Leu Thr Ala His Val Arg Arg 
385                 390                 395                 400 


Asn Ala Leu Arg Val Ala Glu Val Trp Met Asp Glu Phe Lys Ser His 
                405                 410                 415     


Val Tyr Met Ala Trp Asn Ile Pro Gln Glu Asp Ser Gly Ile Asp Ile 
            420                 425                 430         


Gly Asp Ile Thr Ala Arg Lys Ala Leu Arg Lys Gln Leu Gln Cys Lys 
        435                 440                 445             


Thr Phe Arg Trp Tyr Leu Val Ser Val Tyr Pro Glu Met Arg Met Tyr 
    450                 455                 460                 


Ser Asp Ile Ile Ala Tyr Gly Val Leu Gln Asn Ser Leu Lys Thr Asp 
465                 470                 475                 480 


Leu Cys Leu Asp Gln Gly Pro Asp Thr Glu Asn Val Pro Ile Met Tyr 
                485                 490                 495     


Ile Cys His Gly Met Thr Pro Gln Asn Val Tyr Tyr Thr Ser Ser Gln 
            500                 505                 510         


Gln Ile His Val Gly Ile Leu Ser Pro Thr Val Asp Asp Asp Asp Asn 
        515                 520                 525             


Arg Cys Leu Val Asp Val Asn Ser Arg Pro Arg Leu Ile Glu Cys Ser 
    530                 535                 540                 


Tyr Ala Lys Ala Lys Arg Met Lys Leu His Trp Gln Phe Ser Gln Gly 
545                 550                 555                 560 


Gly Pro Ile Gln Asn Arg Lys Ser Lys Arg Cys Leu Glu Leu Gln Glu 
                565                 570                 575     


Asn Ser Asp Leu Glu Phe Gly Phe Gln Leu Val Leu Gln Lys Cys Ser 
            580                 585                 590         


Gly Gln His Trp Ser Ile Thr Asn Val Leu Arg Ser Leu Ala Ser 
        595                 600                 605         


<210>  4316
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT1__Homo_sapiens__XP_005258296

<400>  4316

Met Arg Lys Phe Ala Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Ile 
1               5                   10                  15      


Trp Val Leu Leu Asp Met Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Glu Lys Lys Glu Arg Gly Leu Pro Ala Gly Asp Val Leu 
        35                  40                  45              


Glu Pro Val Gln Lys Pro His Glu Gly Pro Gly Glu Met Gly Lys Pro 
    50                  55                  60                  


Val Val Ile Pro Lys Glu Asp Gln Glu Lys Met Lys Glu Met Phe Lys 
65                  70                  75                  80  


Ile Asn Gln Phe Asn Leu Met Ala Ser Glu Met Ile Ala Leu Asn Arg 
                85                  90                  95      


Ser Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro 
            100                 105                 110         


Asp Asn Leu Pro Thr Thr Ser Val Val Ile Val Phe His Asn Glu Ala 
        115                 120                 125             


Trp Ser Thr Leu Leu Arg Thr Val His Ser Val Ile Asn Arg Ser Pro 
    130                 135                 140                 


Arg His Met Ile Glu Glu Ile Val Leu Val Asp Asp Ala Ser Glu Arg 
145                 150                 155                 160 


Asp Phe Leu Lys Arg Pro Leu Glu Ser Tyr Val Lys Lys Leu Lys Val 
                165                 170                 175     


Pro Val His Val Ile Arg Met Glu Gln Arg Ser Gly Leu Ile Arg Ala 
            180                 185                 190         


Arg Leu Lys Gly Ala Ala Val Ser Lys Gly Gln Val Ile Thr Phe Leu 
        195                 200                 205             


Asp Ala His Cys Glu Cys Thr Val Gly Trp Leu Glu Pro Leu Leu Ala 
    210                 215                 220                 


Arg Ile Lys His Asp Arg Arg Thr Val Val Cys Pro Ile Ile Asp Val 
225                 230                 235                 240 


Ile Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr 
                245                 250                 255     


Gly Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr 
        275                 280                 285             


Pro Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asp Tyr Phe Gln 
    290                 295                 300                 


Glu Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn 
305                 310                 315                 320 


Leu Glu Ile Ser Phe Arg Ile Trp Gln Cys Gly Gly Thr Leu Glu Ile 
                325                 330                 335     


Val Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr 
            340                 345                 350         


Thr Phe Pro Gly Gly Thr Gly Gln Ile Ile Asn Lys Asn Asn Arg Arg 
        355                 360                 365             


Leu Ala Glu Val Trp Met Asp Glu Phe Lys Asn Phe Phe Tyr Ile Ile 
    370                 375                 380                 


Ser Pro Gly Val Thr Lys Val Asp Tyr Gly Asp Ile Ser Ser Arg Val 
385                 390                 395                 400 


Gly Leu Arg His Lys Leu Gln Cys Lys Pro Phe Ser Trp Tyr Leu Glu 
                405                 410                 415     


Asn Ile Tyr Pro Asp Ser Gln Ile Pro Arg His Tyr Phe Ser Leu Gly 
            420                 425                 430         


Glu Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Ala Arg 
        435                 440                 445             


Lys Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly 
    450                 455                 460                 


Asn Gln Val Phe Ser Tyr Thr Ala Asn Lys Glu Ile Arg Thr Asp Asp 
465                 470                 475                 480 


Leu Cys Leu Asp Val Ser Lys Leu Asn Gly Pro Val Thr Met Leu Lys 
                485                 490                 495     


Cys His His Leu Lys Gly Asn Gln Leu Trp Glu Tyr Asp Pro Val Lys 
            500                 505                 510         


Leu Thr Leu Gln His Val Asn Ser Asn Gln Cys Leu Asp Lys Ala Thr 
        515                 520                 525             


Glu Glu Asp Ser Gln Val Pro Ser Ile Arg Asp Cys Asn Gly Ser Arg 
    530                 535                 540                 


Ser Gln Gln Trp Leu Leu Arg Asn Val Thr Leu Pro Glu Ile Phe 
545                 550                 555                 


<210>  4317
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT2__Homo_sapiens__NP_001278795

<400>  4317

Met Ala Asp Arg Glu Asp Trp Asn Glu Ile Asp Pro Ile Lys Lys Lys 
1               5                   10                  15      


Asp Leu His His Ser Asn Gly Glu Glu Lys Ala Gln Ser Met Glu Thr 
            20                  25                  30          


Leu Pro Pro Gly Lys Val Arg Trp Pro Asp Phe Asn Gln Glu Ala Tyr 
        35                  40                  45              


Val Gly Gly Thr Met Val Arg Ser Gly Gln Asp Pro Tyr Ala Arg Asn 
    50                  55                  60                  


Lys Phe Asn Gln Val Glu Ser Asp Lys Leu Arg Met Asp Arg Ala Ile 
65                  70                  75                  80  


Pro Asp Thr Arg His Asp Gln Cys Gln Arg Lys Gln Trp Arg Val Asp 
                85                  90                  95      


Leu Pro Ala Thr Ser Val Val Ile Thr Phe His Asn Glu Ala Arg Ser 
            100                 105                 110         


Ala Leu Leu Arg Thr Val Val Ser Val Leu Lys Lys Ser Pro Pro His 
        115                 120                 125             


Leu Ile Lys Glu Ile Ile Leu Val Asp Asp Tyr Ser Asn Asp Pro Glu 
    130                 135                 140                 


Asp Gly Ala Leu Leu Gly Lys Ile Glu Lys Val Arg Val Leu Arg Asn 
145                 150                 155                 160 


Asp Arg Arg Glu Gly Leu Met Arg Ser Arg Val Arg Gly Ala Asp Ala 
                165                 170                 175     


Ala Gln Ala Lys Val Leu Thr Phe Leu Asp Ser His Cys Glu Cys Asn 
            180                 185                 190         


Glu His Trp Leu Glu Pro Leu Leu Glu Arg Val Ala Glu Asp Arg Thr 
        195                 200                 205             


Arg Val Val Ser Pro Ile Ile Asp Val Ile Asn Met Asp Asn Phe Gln 
    210                 215                 220                 


Tyr Val Gly Ala Ser Ala Asp Leu Lys Gly Gly Phe Asp Trp Asn Leu 
225                 230                 235                 240 


Val Phe Lys Trp Asp Tyr Met Thr Pro Glu Gln Arg Arg Ser Arg Gln 
                245                 250                 255     


Gly Asn Pro Val Ala Pro Ile Lys Thr Pro Met Ile Ala Gly Gly Leu 
            260                 265                 270         


Phe Val Met Asp Lys Phe Tyr Phe Glu Glu Leu Gly Lys Tyr Asp Met 
        275                 280                 285             


Met Met Asp Val Trp Gly Gly Glu Asn Leu Glu Ile Ser Phe Arg Val 
    290                 295                 300                 


Trp Gln Cys Gly Gly Ser Leu Glu Ile Ile Pro Cys Ser Arg Val Gly 
305                 310                 315                 320 


His Val Phe Arg Lys Gln His Pro Tyr Thr Phe Pro Gly Gly Ser Gly 
                325                 330                 335     


Thr Val Phe Ala Arg Asn Thr Arg Arg Ala Ala Glu Val Trp Met Asp 
            340                 345                 350         


Glu Tyr Lys Asn Phe Tyr Tyr Ala Ala Val Pro Ser Ala Arg Asn Val 
        355                 360                 365             


Pro Tyr Gly Asn Ile Gln Ser Arg Leu Glu Leu Arg Lys Lys Leu Ser 
    370                 375                 380                 


Cys Lys Pro Phe Lys Trp Tyr Leu Glu Asn Val Tyr Pro Glu Leu Arg 
385                 390                 395                 400 


Val Pro Asp His Gln Asp Ile Ala Phe Gly Ala Leu Gln Gln Gly Thr 
                405                 410                 415     


Asn Cys Leu Asp Thr Leu Gly His Phe Ala Asp Gly Val Val Gly Val 
            420                 425                 430         


Tyr Glu Cys His Asn Ala Gly Gly Asn Gln Glu Trp Ala Leu Thr Lys 
        435                 440                 445             


Glu Lys Ser Val Lys His Met Asp Leu Cys Leu Thr Val Val Asp Arg 
    450                 455                 460                 


Ala Pro Gly Ser Leu Ile Lys Leu Gln Gly Cys Arg Glu Asn Asp Ser 
465                 470                 475                 480 


Arg Gln Lys Trp Glu Gln Ile Glu Gly Asn Ser Lys Leu Arg His Val 
                485                 490                 495     


Gly Ser Asn Leu Cys Leu Asp Ser Arg Thr Ala Lys Ser Gly Gly Leu 
            500                 505                 510         


Ser Val Glu Val Cys Gly Pro Ala Leu Ser Gln Gln Trp Lys Phe Thr 
        515                 520                 525             


Leu Asn Leu Gln Gln 
    530             


<210>  4318
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT3__Homo_sapiens__NP_004473

<400>  4318

Met Ala His Leu Lys Arg Leu Val Lys Leu His Ile Lys Arg His Tyr 
1               5                   10                  15      


His Lys Lys Phe Trp Lys Leu Gly Ala Val Ile Phe Phe Phe Ile Ile 
            20                  25                  30          


Val Leu Val Leu Met Gln Arg Glu Val Ser Val Gln Tyr Ser Lys Glu 
        35                  40                  45              


Glu Ser Arg Met Glu Arg Asn Met Lys Asn Lys Asn Lys Met Leu Asp 
    50                  55                  60                  


Leu Met Leu Glu Ala Val Asn Asn Ile Lys Asp Ala Met Pro Lys Met 
65                  70                  75                  80  


Gln Ile Gly Ala Pro Val Arg Gln Asn Ile Asp Ala Gly Glu Arg Pro 
                85                  90                  95      


Cys Leu Gln Gly Tyr Tyr Thr Ala Ala Glu Leu Lys Pro Val Leu Asp 
            100                 105                 110         


Arg Pro Pro Gln Asp Ser Asn Ala Pro Gly Ala Ser Gly Lys Ala Phe 
        115                 120                 125             


Lys Thr Thr Asn Leu Ser Val Glu Glu Gln Lys Glu Lys Glu Arg Gly 
    130                 135                 140                 


Glu Ala Lys His Cys Phe Asn Ala Phe Ala Ser Asp Arg Ile Ser Leu 
145                 150                 155                 160 


His Arg Asp Leu Gly Pro Asp Thr Arg Pro Pro Glu Cys Ile Glu Gln 
                165                 170                 175     


Lys Phe Lys Arg Cys Pro Pro Leu Pro Thr Thr Ser Val Ile Ile Val 
            180                 185                 190         


Phe His Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val His Ser Val 
        195                 200                 205             


Leu Tyr Ser Ser Pro Ala Ile Leu Leu Lys Glu Ile Ile Leu Val Asp 
    210                 215                 220                 


Asp Ala Ser Val Asp Glu Tyr Leu His Asp Lys Leu Asp Glu Tyr Val 
225                 230                 235                 240 


Lys Gln Phe Ser Ile Val Lys Ile Val Arg Gln Arg Glu Arg Lys Gly 
                245                 250                 255     


Leu Ile Thr Ala Arg Leu Leu Gly Ala Thr Val Ala Thr Ala Glu Thr 
            260                 265                 270         


Leu Thr Phe Leu Asp Ala His Cys Glu Cys Phe Tyr Gly Trp Leu Glu 
        275                 280                 285             


Pro Leu Leu Ala Arg Ile Ala Glu Asn Tyr Thr Ala Val Val Ser Pro 
    290                 295                 300                 


Asp Ile Ala Ser Ile Asp Leu Asn Thr Phe Glu Phe Asn Lys Pro Ser 
305                 310                 315                 320 


Pro Tyr Gly Ser Asn His Asn Arg Gly Asn Phe Asp Trp Ser Leu Ser 
                325                 330                 335     


Phe Gly Trp Glu Ser Leu Pro Asp His Glu Lys Gln Arg Arg Lys Asp 
            340                 345                 350         


Glu Thr Tyr Pro Ile Lys Thr Pro Thr Phe Ala Gly Gly Leu Phe Ser 
        355                 360                 365             


Ile Ser Lys Glu Tyr Phe Glu Tyr Ile Gly Ser Tyr Asp Glu Glu Met 
    370                 375                 380                 


Glu Ile Trp Gly Gly Glu Asn Ile Glu Met Ser Phe Arg Val Trp Gln 
385                 390                 395                 400 


Cys Gly Gly Gln Leu Glu Ile Met Pro Cys Ser Val Val Gly His Val 
                405                 410                 415     


Phe Arg Ser Lys Ser Pro His Ser Phe Pro Lys Gly Thr Gln Val Ile 
            420                 425                 430         


Ala Arg Asn Gln Val Arg Leu Ala Glu Val Trp Met Asp Glu Tyr Lys 
        435                 440                 445             


Glu Ile Phe Tyr Arg Arg Asn Thr Asp Ala Ala Lys Ile Val Lys Gln 
    450                 455                 460                 


Lys Ala Phe Gly Asp Leu Ser Lys Arg Phe Glu Ile Lys His Arg Leu 
465                 470                 475                 480 


Gln Cys Lys Asn Phe Thr Trp Tyr Leu Asn Asn Ile Tyr Pro Glu Val 
                485                 490                 495     


Tyr Val Pro Asp Leu Asn Pro Val Ile Ser Gly Tyr Ile Lys Ser Val 
            500                 505                 510         


Gly Gln Pro Leu Cys Leu Asp Val Gly Glu Asn Asn Gln Gly Gly Lys 
        515                 520                 525             


Pro Leu Ile Met Tyr Thr Cys His Gly Leu Gly Gly Asn Gln Tyr Phe 
    530                 535                 540                 


Glu Tyr Ser Ala Gln His Glu Ile Arg His Asn Ile Gln Lys Glu Leu 
545                 550                 555                 560 


Cys Leu His Ala Ala Gln Gly Leu Val Gln Leu Lys Ala Cys Thr Tyr 
                565                 570                 575     


Lys Gly His Lys Thr Val Val Thr Gly Glu Gln Ile Trp Glu Ile Gln 
            580                 585                 590         


Lys Asp Gln Leu Leu Tyr Asn Pro Phe Leu Lys Met Cys Leu Ser Ala 
        595                 600                 605             


Asn Gly Glu His Pro Ser Leu Val Ser Cys Asn Pro Ser Asp Pro Leu 
    610                 615                 620                 


Gln Lys Trp Ile Leu Ser Gln Asn Asp 
625                 630             


<210>  4319
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT4__Homo_sapiens__NP_003765

<400>  4319

Met Ala Val Arg Trp Thr Trp Ala Gly Lys Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Phe Leu Thr Val Ala Tyr Ile Phe Val Glu Leu Leu Val Ser Thr Phe 
            20                  25                  30          


His Ala Ser Ala Gly Ala Gly Arg Ala Arg Glu Leu Gly Ser Arg Arg 
        35                  40                  45              


Leu Ser Asp Leu Gln Lys Asn Thr Glu Asp Leu Ser Arg Pro Leu Tyr 
    50                  55                  60                  


Lys Lys Pro Pro Ala Asp Ser Arg Ala Leu Gly Glu Trp Gly Lys Ala 
65                  70                  75                  80  


Ser Lys Leu Gln Leu Asn Glu Asp Glu Leu Lys Gln Gln Glu Glu Leu 
                85                  90                  95      


Ile Glu Arg Tyr Ala Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser Leu 
            100                 105                 110         


His Arg His Ile Glu Asp Lys Arg Met Tyr Glu Cys Lys Ser Gln Lys 
        115                 120                 125             


Phe Asn Tyr Arg Thr Leu Pro Thr Thr Ser Val Ile Ile Ala Phe Tyr 
    130                 135                 140                 


Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Ile His Ser Val Leu Glu 
145                 150                 155                 160 


Thr Ser Pro Ala Val Leu Leu Lys Glu Ile Ile Leu Val Asp Asp Leu 
                165                 170                 175     


Ser Asp Arg Val Tyr Leu Lys Thr Gln Leu Glu Thr Tyr Ile Ser Asn 
            180                 185                 190         


Leu Asp Arg Val Arg Leu Ile Arg Thr Asn Lys Arg Glu Gly Leu Val 
        195                 200                 205             


Arg Ala Arg Leu Ile Gly Ala Thr Phe Ala Thr Gly Asp Val Leu Thr 
    210                 215                 220                 


Phe Leu Asp Cys His Cys Glu Cys Asn Ser Gly Trp Leu Glu Pro Leu 
225                 230                 235                 240 


Leu Glu Arg Ile Gly Arg Asp Glu Thr Ala Val Val Cys Pro Val Ile 
                245                 250                 255     


Asp Thr Ile Asp Trp Asn Thr Phe Glu Phe Tyr Met Gln Ile Gly Glu 
            260                 265                 270         


Pro Met Ile Gly Gly Phe Asp Trp Arg Leu Thr Phe Gln Trp His Ser 
        275                 280                 285             


Val Pro Lys Gln Glu Arg Asp Arg Arg Ile Ser Arg Ile Asp Pro Ile 
    290                 295                 300                 


Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys Tyr 
305                 310                 315                 320 


Phe Gln Tyr Leu Gly Thr Tyr Asp Thr Gly Met Glu Val Trp Gly Gly 
                325                 330                 335     


Glu Asn Leu Glu Leu Ser Phe Arg Val Trp Gln Cys Gly Gly Lys Leu 
            340                 345                 350         


Glu Ile His Pro Cys Ser His Val Gly His Val Phe Pro Lys Arg Ala 
        355                 360                 365             


Pro Tyr Ala Arg Pro Asn Phe Leu Gln Asn Thr Ala Arg Ala Ala Glu 
    370                 375                 380                 


Val Trp Met Asp Glu Tyr Lys Glu His Phe Tyr Asn Arg Asn Pro Pro 
385                 390                 395                 400 


Ala Arg Lys Glu Ala Tyr Gly Asp Ile Ser Glu Arg Lys Leu Leu Arg 
                405                 410                 415     


Glu Arg Leu Arg Cys Lys Ser Phe Asp Trp Tyr Leu Lys Asn Val Phe 
            420                 425                 430         


Pro Asn Leu His Val Pro Glu Asp Arg Pro Gly Trp His Gly Ala Ile 
        435                 440                 445             


Arg Ser Arg Gly Ile Ser Ser Glu Cys Leu Asp Tyr Asn Ser Pro Asp 
    450                 455                 460                 


Asn Asn Pro Thr Gly Ala Asn Leu Ser Leu Phe Gly Cys His Gly Gln 
465                 470                 475                 480 


Gly Gly Asn Gln Phe Phe Glu Tyr Thr Ser Asn Lys Glu Ile Arg Phe 
                485                 490                 495     


Asn Ser Val Thr Glu Leu Cys Ala Glu Val Pro Glu Gln Lys Asn Tyr 
            500                 505                 510         


Val Gly Met Gln Asn Cys Pro Lys Asp Gly Phe Pro Val Pro Ala Asn 
        515                 520                 525             


Ile Ile Trp His Phe Lys Glu Asp Gly Thr Ile Phe His Pro His Ser 
    530                 535                 540                 


Gly Leu Cys Leu Ser Ala Tyr Arg Thr Pro Glu Gly Arg Pro Asp Val 
545                 550                 555                 560 


Gln Met Arg Thr Cys Asp Ala Leu Asp Lys Asn Gln Ile Trp Ser Phe 
                565                 570                 575     


Glu Lys 
        


<210>  4320
<211>  940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT5__Homo_sapiens__NP_055383

<400>  4320

Met Asn Arg Ile Arg Lys Phe Phe Arg Gly Ser Gly Arg Val Leu Ala 
1               5                   10                  15      


Phe Ile Phe Val Ala Ser Val Ile Trp Leu Leu Phe Asp Met Ala Ala 
            20                  25                  30          


Leu Arg Leu Ser Phe Ser Glu Ile Asn Thr Arg Val Ile Lys Glu Asp 
        35                  40                  45              


Ile Val Arg Arg Glu Arg Ile Gly Phe Arg Val Gln Pro Asp Gln Gly 
    50                  55                  60                  


Lys Ile Phe Tyr Ser Ser Ile Lys Glu Met Lys Pro Pro Leu Arg Gly 
65                  70                  75                  80  


His Gly Lys Gly Ala Trp Gly Lys Glu Asn Val Arg Lys Thr Glu Glu 
                85                  90                  95      


Ser Val Leu Lys Val Glu Val Asp Leu Asp Gln Thr Gln Arg Glu Arg 
            100                 105                 110         


Lys Met Gln Asn Ala Leu Gly Arg Gly Lys Val Val Pro Leu Trp His 
        115                 120                 125             


Pro Ala His Leu Gln Thr Leu Pro Val Thr Pro Asn Lys Gln Lys Thr 
    130                 135                 140                 


Asp Gly Arg Gly Thr Lys Pro Glu Ala Ser Ser His Gln Gly Thr Pro 
145                 150                 155                 160 


Lys Gln Thr Thr Ala Gln Gly Ala Pro Lys Thr Ser Phe Ile Ala Ala 
                165                 170                 175     


Lys Gly Thr Gln Val Val Lys Ile Ser Val His Met Gly Arg Val Ser 
            180                 185                 190         


Leu Lys Gln Glu Pro Arg Lys Ser His Ser Pro Ser Ser Asp Thr Ser 
        195                 200                 205             


Lys Leu Ala Ala Glu Arg Asp Leu Asn Val Thr Ile Ser Leu Ser Thr 
    210                 215                 220                 


Asp Arg Pro Lys Gln Arg Ser Gln Ala Val Ala Asn Glu Arg Ala His 
225                 230                 235                 240 


Pro Ala Ser Thr Ala Val Pro Lys Ser Gly Glu Ala Met Ala Leu Asn 
                245                 250                 255     


Lys Thr Lys Thr Gln Ser Lys Glu Val Asn Ala Asn Lys His Lys Ala 
            260                 265                 270         


Asn Thr Ser Leu Pro Phe Pro Lys Phe Thr Val Asn Ser Asn Arg Leu 
        275                 280                 285             


Arg Lys Gln Ser Ile Asn Glu Thr Pro Leu Gly Ser Leu Ser Lys Asp 
    290                 295                 300                 


Asp Gly Ala Arg Gly Ala His Gly Lys Lys Leu Asn Phe Ser Glu Ser 
305                 310                 315                 320 


His Leu Val Ile Ile Thr Lys Glu Glu Glu Gln Lys Ala Asp Pro Lys 
                325                 330                 335     


Glu Val Ser Asn Ser Lys Thr Lys Thr Ile Phe Pro Lys Val Leu Gly 
            340                 345                 350         


Lys Ser Gln Ser Lys His Ile Ser Arg Asn Arg Ser Glu Met Ser Ser 
        355                 360                 365             


Ser Ser Leu Ala Pro His Arg Val Pro Leu Ser Gln Thr Asn His Ala 
    370                 375                 380                 


Leu Thr Gly Gly Leu Glu Pro Ala Lys Ile Asn Ile Thr Ala Lys Ala 
385                 390                 395                 400 


Pro Ser Thr Glu Tyr Asn Gln Ser His Ile Lys Ala Leu Leu Pro Glu 
                405                 410                 415     


Asp Ser Gly Thr His Gln Val Leu Arg Ile Asp Val Thr Leu Ser Pro 
            420                 425                 430         


Arg Asp Pro Lys Ala Pro Gly Gln Phe Gly Arg Pro Val Val Val Pro 
        435                 440                 445             


His Gly Lys Glu Lys Glu Ala Glu Arg Arg Trp Lys Glu Gly Asn Phe 
    450                 455                 460                 


Asn Val Tyr Leu Ser Asp Leu Ile Pro Val Asp Arg Ala Ile Glu Asp 
465                 470                 475                 480 


Thr Arg Pro Ala Gly Cys Ala Glu Gln Leu Val His Asn Asn Leu Pro 
                485                 490                 495     


Thr Thr Ser Val Ile Met Cys Phe Val Asp Glu Val Trp Ser Thr Leu 
            500                 505                 510         


Leu Arg Ser Val His Ser Val Ile Asn Arg Ser Pro Pro His Leu Ile 
        515                 520                 525             


Lys Glu Ile Leu Leu Val Asp Asp Phe Ser Thr Lys Asp Tyr Leu Lys 
    530                 535                 540                 


Asp Asn Leu Asp Lys Tyr Met Ser Gln Phe Pro Lys Val Arg Ile Leu 
545                 550                 555                 560 


Arg Leu Lys Glu Arg His Gly Leu Ile Arg Ala Arg Leu Ala Gly Ala 
                565                 570                 575     


Gln Asn Ala Thr Gly Asp Val Leu Thr Phe Leu Asp Ser His Val Glu 
            580                 585                 590         


Cys Asn Val Gly Trp Leu Glu Pro Leu Leu Glu Arg Val Tyr Leu Ser 
        595                 600                 605             


Arg Lys Lys Val Ala Cys Pro Val Ile Glu Val Ile Asn Asp Lys Asp 
    610                 615                 620                 


Met Ser Tyr Met Thr Val Asp Asn Phe Gln Arg Gly Ile Phe Val Trp 
625                 630                 635                 640 


Pro Met Asn Phe Gly Trp Arg Thr Ile Pro Pro Asp Val Ile Ala Lys 
                645                 650                 655     


Asn Arg Ile Lys Glu Thr Asp Thr Ile Arg Cys Pro Val Met Ala Gly 
            660                 665                 670         


Gly Leu Phe Ser Ile Asp Lys Ser Tyr Phe Phe Glu Leu Gly Thr Tyr 
        675                 680                 685             


Asp Pro Gly Leu Asp Val Trp Gly Gly Glu Asn Met Glu Leu Ser Phe 
    690                 695                 700                 


Lys Val Trp Met Cys Gly Gly Glu Ile Glu Ile Ile Pro Cys Ser Arg 
705                 710                 715                 720 


Val Gly His Ile Phe Arg Asn Asp Asn Pro Tyr Ser Phe Pro Lys Asp 
                725                 730                 735     


Arg Met Lys Thr Val Glu Arg Asn Leu Val Arg Val Ala Glu Val Trp 
            740                 745                 750         


Leu Asp Glu Tyr Lys Glu Leu Phe Tyr Gly His Gly Asp His Leu Ile 
        755                 760                 765             


Asp Gln Gly Leu Asp Val Gly Asn Leu Thr Gln Gln Arg Glu Leu Arg 
    770                 775                 780                 


Lys Lys Leu Lys Cys Lys Ser Phe Lys Trp Tyr Leu Glu Asn Val Phe 
785                 790                 795                 800 


Pro Asp Leu Arg Ala Pro Ile Val Arg Ala Ser Gly Val Leu Ile Asn 
                805                 810                 815     


Val Ala Leu Gly Lys Cys Ile Ser Ile Glu Asn Thr Thr Val Ile Leu 
            820                 825                 830         


Glu Asp Cys Asp Gly Ser Lys Glu Leu Gln Gln Phe Asn Tyr Thr Trp 
        835                 840                 845             


Leu Arg Leu Ile Lys Cys Gly Glu Trp Cys Ile Ala Pro Ile Pro Asp 
    850                 855                 860                 


Lys Gly Ala Val Arg Leu His Pro Cys Asp Asn Arg Asn Lys Gly Leu 
865                 870                 875                 880 


Lys Trp Leu His Lys Ser Thr Ser Val Phe His Pro Glu Leu Val Asn 
                885                 890                 895     


His Ile Val Phe Glu Asn Asn Gln Gln Leu Leu Cys Leu Glu Gly Asn 
            900                 905                 910         


Phe Ser Gln Lys Ile Leu Lys Val Ala Ala Cys Asp Pro Val Lys Pro 
        915                 920                 925             


Tyr Gln Lys Trp Lys Phe Glu Lys Tyr Tyr Glu Ala 
    930                 935                 940 


<210>  4321
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT6__Homo_sapiens__XP_006719277

<400>  4321

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr Lys Lys His Cys Phe Asn Ala 
    130                 135                 140                 


Phe Ala Ser Asp Arg Ile Ser Leu Gln Arg Ser Leu Gly Pro Asp Thr 
145                 150                 155                 160 


Arg Pro Pro Glu Cys Val Asp Gln Lys Phe Arg Arg Cys Pro Pro Leu 
                165                 170                 175     


Ala Thr Thr Ser Val Ile Ile Val Phe His Asn Glu Ala Trp Ser Thr 
            180                 185                 190         


Leu Leu Arg Thr Val Tyr Ser Val Leu His Thr Thr Pro Ala Ile Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Leu Val Asp Asp Ala Ser Thr Glu Glu His Leu 
    210                 215                 220                 


Lys Glu Lys Leu Glu Gln Tyr Val Lys Gln Leu Gln Val Val Arg Val 
225                 230                 235                 240 


Val Arg Gln Glu Glu Arg Lys Gly Leu Ile Thr Ala Arg Leu Leu Gly 
                245                 250                 255     


Ala Ser Val Ala Gln Ala Glu Val Leu Thr Phe Leu Asp Ala His Cys 
            260                 265                 270         


Glu Cys Phe His Gly Trp Leu Glu Pro Leu Leu Ala Arg Ile Ala Glu 
        275                 280                 285             


Asp Lys Thr Val Val Val Ser Pro Asp Ile Val Thr Ile Asp Leu Asn 
    290                 295                 300                 


Thr Phe Glu Phe Ala Lys Pro Val Gln Arg Gly Arg Val His Ser Arg 
305                 310                 315                 320 


Gly Asn Phe Asp Trp Ser Leu Thr Phe Gly Trp Glu Thr Leu Pro Pro 
                325                 330                 335     


His Glu Lys Gln Arg Arg Lys Asp Glu Thr Tyr Pro Ile Lys Ser Pro 
            340                 345                 350         


Thr Phe Ala Gly Gly Leu Phe Ser Ile Ser Lys Ser Tyr Phe Glu His 
        355                 360                 365             


Ile Gly Thr Tyr Asp Asn Gln Met Glu Ile Trp Gly Gly Glu Asn Val 
    370                 375                 380                 


Glu Met Ser Phe Arg Val Trp Gln Cys Gly Gly Gln Leu Glu Ile Ile 
385                 390                 395                 400 


Pro Cys Ser Val Val Gly His Val Phe Arg Thr Lys Ser Pro His Thr 
                405                 410                 415     


Phe Pro Lys Gly Thr Ser Val Ile Ala Arg Asn Gln Val Arg Leu Ala 
            420                 425                 430         


Glu Val Trp Met Asp Ser Tyr Lys Lys Ile Phe Tyr Arg Arg Asn Leu 
        435                 440                 445             


Gln Ala Ala Lys Met Ala Gln Glu Lys Ser Phe Gly Asp Ile Ser Glu 
    450                 455                 460                 


Arg Leu Gln Leu Arg Glu Gln Leu His Cys His Asn Phe Ser Trp Tyr 
465                 470                 475                 480 


Leu His Asn Val Tyr Pro Glu Met Phe Val Pro Asp Leu Thr Pro Thr 
                485                 490                 495     


Phe Tyr Gly Ala Ile Lys Asn Leu Gly Thr Asn Gln Cys Leu Asp Val 
            500                 505                 510         


Gly Glu Asn Asn Arg Gly Gly Lys Pro Leu Ile Met Tyr Ser Cys His 
        515                 520                 525             


Gly Leu Gly Gly Asn Gln Tyr Phe Glu Tyr Thr Thr Gln Arg Asp Leu 
    530                 535                 540                 


Arg His Asn Ile Ala Lys Gln Leu Cys Leu His Val Ser Lys Gly Ala 
545                 550                 555                 560 


Leu Gly Leu Gly Ser Cys His Phe Thr Gly Lys Asn Ser Gln Val Pro 
                565                 570                 575     


Lys Asp Glu Glu Trp Glu Leu Ala Gln Asp Gln Leu Ile Arg Asn Ser 
            580                 585                 590         


Gly Ser Gly Thr Cys Leu Thr Ser Gln Asp Lys Lys Pro Ala Met Ala 
        595                 600                 605             


Pro Cys Asn Pro Ser Asp Pro His Gln Leu Trp Leu Phe Val 
    610                 615                 620         


<210>  4322
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT7__Homo_sapiens__NP_059119

<400>  4322

Met Arg Leu Lys Ile Gly Phe Ile Leu Arg Ser Leu Leu Val Val Gly 
1               5                   10                  15      


Ser Phe Leu Gly Leu Val Val Leu Trp Ser Ser Leu Thr Pro Arg Pro 
            20                  25                  30          


Asp Asp Pro Ser Pro Leu Ser Arg Met Arg Glu Asp Arg Asp Val Asn 
        35                  40                  45              


Asp Pro Met Pro Asn Arg Gly Gly Asn Gly Leu Ala Pro Gly Glu Asp 
    50                  55                  60                  


Arg Phe Lys Pro Val Val Pro Trp Pro His Val Glu Gly Val Glu Val 
65                  70                  75                  80  


Asp Leu Glu Ser Ile Arg Arg Ile Asn Lys Ala Lys Asn Glu Gln Glu 
                85                  90                  95      


His His Ala Gly Gly Asp Ser Gln Lys Asp Ile Met Gln Arg Gln Tyr 
            100                 105                 110         


Leu Thr Phe Lys Pro Gln Thr Phe Thr Tyr His Asp Pro Val Leu Arg 
        115                 120                 125             


Pro Gly Ile Leu Gly Asn Phe Glu Pro Lys Glu Pro Glu Pro Pro Gly 
    130                 135                 140                 


Val Val Gly Gly Pro Gly Glu Lys Ala Lys Pro Leu Val Leu Gly Pro 
145                 150                 155                 160 


Glu Phe Lys Gln Ala Ile Gln Ala Ser Ile Lys Glu Phe Gly Phe Asn 
                165                 170                 175     


Met Val Ala Ser Asp Met Ile Ser Leu Asp Arg Ser Val Asn Asp Leu 
            180                 185                 190         


Arg Gln Glu Glu Cys Lys Tyr Trp His Tyr Asp Glu Asn Leu Leu Thr 
        195                 200                 205             


Ser Ser Val Val Ile Val Phe His Asn Glu Gly Trp Ser Thr Leu Met 
    210                 215                 220                 


Arg Thr Val His Ser Val Ile Lys Arg Thr Pro Arg Lys Tyr Leu Ala 
225                 230                 235                 240 


Glu Ile Val Leu Ile Asp Asp Phe Ser Asn Lys Glu His Leu Lys Glu 
                245                 250                 255     


Lys Leu Asp Glu Tyr Ile Lys Leu Trp Asn Gly Leu Val Lys Val Phe 
            260                 265                 270         


Arg Asn Glu Arg Arg Glu Gly Leu Ile Gln Ala Arg Ser Ile Gly Ala 
        275                 280                 285             


Gln Lys Ala Lys Leu Gly Gln Val Leu Ile Tyr Leu Asp Ala His Cys 
    290                 295                 300                 


Glu Val Ala Val Asn Trp Tyr Ala Pro Leu Val Ala Pro Ile Ser Lys 
305                 310                 315                 320 


Asp Arg Thr Ile Cys Thr Val Pro Leu Ile Asp Val Ile Asn Gly Asn 
                325                 330                 335     


Thr Tyr Glu Ile Ile Pro Gln Gly Gly Gly Asp Glu Asp Gly Tyr Ala 
            340                 345                 350         


Arg Gly Ala Trp Asp Trp Ser Met Leu Trp Lys Arg Val Pro Leu Thr 
        355                 360                 365             


Pro Gln Glu Lys Arg Leu Arg Lys Thr Lys Thr Glu Pro Tyr Arg Ser 
    370                 375                 380                 


Pro Ala Met Ala Gly Gly Leu Phe Ala Ile Glu Arg Glu Phe Phe Phe 
385                 390                 395                 400 


Glu Leu Gly Leu Tyr Asp Pro Gly Leu Gln Ile Trp Gly Gly Glu Asn 
                405                 410                 415     


Phe Glu Ile Ser Tyr Lys Ile Trp Gln Cys Gly Gly Lys Leu Leu Phe 
            420                 425                 430         


Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg Leu Glu Gly Trp Gln 
        435                 440                 445             


Gly Asn Pro Pro Pro Ile Tyr Val Gly Ser Ser Pro Thr Leu Lys Asn 
    450                 455                 460                 


Tyr Val Arg Val Val Glu Val Trp Trp Asp Glu Tyr Lys Asp Tyr Phe 
465                 470                 475                 480 


Tyr Ala Ser Arg Pro Glu Ser Gln Ala Leu Pro Tyr Gly Asp Ile Ser 
                485                 490                 495     


Glu Leu Lys Lys Phe Arg Glu Asp His Asn Cys Lys Ser Phe Lys Trp 
            500                 505                 510         


Phe Met Glu Glu Ile Ala Tyr Asp Ile Thr Ser His Tyr Pro Leu Pro 
        515                 520                 525             


Pro Lys Asn Val Asp Trp Gly Glu Ile Arg Gly Phe Glu Thr Ala Tyr 
    530                 535                 540                 


Cys Ile Asp Ser Met Gly Lys Thr Asn Gly Gly Phe Val Glu Leu Gly 
545                 550                 555                 560 


Pro Cys His Arg Met Gly Gly Asn Gln Leu Phe Arg Ile Asn Glu Ala 
                565                 570                 575     


Asn Gln Leu Met Gln Tyr Asp Gln Cys Leu Thr Lys Gly Ala Asp Gly 
            580                 585                 590         


Ser Lys Val Met Ile Thr His Cys Asn Leu Asn Glu Phe Lys Glu Trp 
        595                 600                 605             


Gln Tyr Phe Lys Asn Leu His Arg Phe Thr His Ile Pro Ser Gly Lys 
    610                 615                 620                 


Cys Leu Asp Arg Ser Glu Val Leu His Gln Val Phe Ile Ser Asn Cys 
625                 630                 635                 640 


Asp Ser Ser Lys Thr Thr Gln Lys Trp Glu Met Asn Asn Ile His Ser 
                645                 650                 655     


Val 
    


<210>  4323
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT8__Homo_sapiens__NP_059113

<400>  4323

Met Met Phe Trp Arg Lys Leu Pro Lys Ala Leu Phe Ile Gly Leu Thr 
1               5                   10                  15      


Leu Ala Ile Ala Val Asn Leu Leu Leu Val Phe Ser Ser Lys Gly Thr 
            20                  25                  30          


Leu Gln Asn Leu Phe Thr Gly Gly Leu His Arg Glu Leu Pro Leu His 
        35                  40                  45              


Leu Asn Lys Arg Tyr Gly Ala Val Ile Lys Arg Leu Ser His Leu Glu 
    50                  55                  60                  


Val Glu Leu Gln Asp Leu Lys Glu Ser Met Lys Leu Ala Leu Arg Gln 
65                  70                  75                  80  


Gln Glu Asn Val Asn Ser Thr Leu Lys Arg Ala Lys Asp Glu Val Arg 
                85                  90                  95      


Pro Leu Leu Lys Ala Met Glu Thr Lys Val Asn Glu Thr Lys Lys His 
            100                 105                 110         


Lys Thr Gln Met Lys Leu Phe Pro His Ser Gln Leu Phe Arg Gln Trp 
        115                 120                 125             


Gly Glu Asp Leu Ser Glu Ala Gln Gln Lys Ala Ala Gln Asp Leu Phe 
    130                 135                 140                 


Arg Lys Phe Gly Tyr Asn Ala Tyr Leu Ser Asn Gln Leu Pro Leu Asn 
145                 150                 155                 160 


Arg Thr Ile Pro Asp Thr Arg Asp Tyr Arg Cys Leu Arg Lys Thr Tyr 
                165                 170                 175     


Pro Ser Gln Leu Pro Ser Leu Ser Val Ile Leu Ile Phe Val Asn Glu 
            180                 185                 190         


Ala Leu Ser Ile Ile Gln Arg Ala Ile Thr Ser Ile Ile Asn Arg Thr 
        195                 200                 205             


Pro Ser Arg Leu Leu Lys Glu Ile Ile Leu Val Asp Asp Phe Ser Ser 
    210                 215                 220                 


Asn Gly Glu Leu Lys Val His Leu Asp Glu Lys Ile Lys Leu Tyr Asn 
225                 230                 235                 240 


Gln Lys Tyr Pro Gly Leu Leu Lys Ile Ile Arg His Pro Glu Arg Lys 
                245                 250                 255     


Gly Leu Ala Gln Ala Arg Asn Thr Gly Trp Glu Ala Ala Thr Ala Asp 
            260                 265                 270         


Val Val Ala Ile Leu Asp Ala His Ile Glu Val Asn Val Gly Trp Ala 
        275                 280                 285             


Glu Pro Ile Leu Ala Arg Ile Gln Glu Asp Arg Thr Val Ile Val Ser 
    290                 295                 300                 


Pro Val Phe Asp Asn Ile Arg Phe Asp Thr Phe Lys Leu Asp Lys Tyr 
305                 310                 315                 320 


Glu Leu Ala Val Asp Gly Phe Asn Trp Glu Leu Trp Cys Arg Tyr Asp 
                325                 330                 335     


Ala Leu Pro Gln Ala Trp Ile Asp Leu His Asp Val Thr Ala Pro Val 
            340                 345                 350         


Lys Ser Pro Ser Ile Met Gly Ile Leu Ala Ala Asn Arg His Phe Leu 
        355                 360                 365             


Gly Glu Ile Gly Ser Leu Asp Gly Gly Met Leu Ile Tyr Gly Gly Glu 
    370                 375                 380                 


Asn Val Glu Leu Ser Leu Arg Val Trp Gln Cys Gly Gly Lys Val Glu 
385                 390                 395                 400 


Ile Leu Pro Cys Ser Arg Ile Ala His Leu Glu Arg His His Lys Pro 
                405                 410                 415     


Tyr Ala Leu Asp Leu Thr Ala Ala Leu Lys Arg Asn Ala Leu Arg Val 
            420                 425                 430         


Ala Glu Ile Trp Met Asp Glu His Lys His Met Val Tyr Leu Ala Trp 
        435                 440                 445             


Asn Ile Pro Leu Gln Asn Ser Gly Ile Asp Phe Gly Asp Val Ser Ser 
    450                 455                 460                 


Arg Met Ala Leu Arg Glu Lys Leu Lys Cys Lys Thr Phe Asp Trp Tyr 
465                 470                 475                 480 


Leu Lys Asn Val Tyr Pro Leu Leu Lys Pro Leu His Thr Ile Val Gly 
                485                 490                 495     


Tyr Gly Arg Met Lys Asn Leu Leu Asp Glu Asn Val Cys Leu Asp Gln 
            500                 505                 510         


Gly Pro Val Pro Gly Asn Thr Pro Ile Met Tyr Tyr Cys His Glu Phe 
        515                 520                 525             


Ser Ser Gln Asn Val Tyr Tyr His Leu Thr Gly Glu Leu Tyr Val Gly 
    530                 535                 540                 


Gln Leu Ile Ala Glu Ala Ser Ala Ser Asp Arg Cys Leu Thr Asp Pro 
545                 550                 555                 560 


Gly Lys Ala Glu Lys Pro Thr Leu Glu Pro Cys Ser Lys Ala Ala Lys 
                565                 570                 575     


Asn Arg Leu His Ile Tyr Trp Asp Phe Lys Pro Gly Gly Ala Val Ile 
            580                 585                 590         


Asn Arg Asp Thr Lys Arg Cys Leu Glu Met Lys Lys Asp Leu Leu Gly 
        595                 600                 605             


Ser His Val Leu Val Leu Gln Thr Cys Ser Thr Gln Val Trp Glu Ile 
    610                 615                 620                 


Gln His Thr Val Arg Asp Trp Gly Gln Thr Asn Ser Gln 
625                 630                 635         


<210>  4324
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNT9__Homo_sapiens__NP_001116108

<400>  4324

Met Ala Val Ala Arg Lys Ile Arg Thr Leu Leu Thr Val Asn Ile Leu 
1               5                   10                  15      


Val Phe Val Gly Ile Val Leu Phe Ser Val Tyr Cys Arg Leu Gln Gly 
            20                  25                  30          


Arg Ser Gln Glu Leu Val Arg Ile Val Ser Gly Asp Arg Arg Val Arg 
        35                  40                  45              


Ser Arg His Ala Lys Val Gly Thr Leu Gly Asp Arg Glu Ala Ile Leu 
    50                  55                  60                  


Gln Arg Leu Asp His Leu Glu Glu Val Val Tyr Asn Gln Leu Asn Gly 
65                  70                  75                  80  


Leu Ala Lys Pro Ile Gly Leu Val Glu Gly Pro Gly Gly Leu Gly Gln 
                85                  90                  95      


Gly Gly Leu Ala Ala Thr Leu Arg Asp Asp Gly Gln Glu Ala Glu Gly 
            100                 105                 110         


Lys Tyr Glu Glu Tyr Gly Tyr Asn Ala Gln Leu Ser Asp Arg Ile Ser 
        115                 120                 125             


Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Arg Lys Cys Arg Gln Met 
    130                 135                 140                 


Ser Tyr Ala Gln Asp Leu Pro Gln Val Ser Val Val Phe Ile Phe Val 
145                 150                 155                 160 


Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Val Val Asn 
                165                 170                 175     


His Thr Pro Ser Gln Leu Leu Lys Glu Val Ile Leu Val Asp Asp Asn 
            180                 185                 190         


Ser Asp Asn Val Glu Leu Lys Phe Asn Leu Asp Gln Tyr Val Asn Lys 
        195                 200                 205             


Arg Tyr Pro Gly Leu Val Lys Ile Val Arg Asn Ser Arg Arg Glu Gly 
    210                 215                 220                 


Leu Ile Arg Ala Arg Leu Gln Gly Trp Lys Ala Ala Thr Ala Pro Val 
225                 230                 235                 240 


Val Gly Phe Phe Asp Ala His Val Glu Phe Asn Thr Gly Trp Ala Glu 
                245                 250                 255     


Pro Ala Leu Ser Arg Ile Arg Glu Asp Arg Arg Arg Ile Val Leu Pro 
            260                 265                 270         


Ala Ile Asp Asn Ile Lys Tyr Ser Thr Phe Glu Val Gln Gln Tyr Ala 
        275                 280                 285             


Asn Ala Ala His Gly Tyr Asn Trp Gly Leu Trp Cys Met Tyr Ile Ile 
    290                 295                 300                 


Pro Pro Gln Asp Trp Leu Asp Arg Gly Asp Glu Ser Ala Pro Ile Arg 
305                 310                 315                 320 


Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asp Arg Glu Tyr Phe 
                325                 330                 335     


Gly Asp Ile Gly Leu Leu Asp Pro Gly Met Glu Val Tyr Gly Gly Glu 
            340                 345                 350         


Asn Val Glu Leu Gly Met Arg Val Trp Gln Cys Gly Gly Ser Met Glu 
        355                 360                 365             


Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Thr Arg Lys Pro 
    370                 375                 380                 


Tyr Asn Asn Asp Ile Asp Tyr Tyr Ala Lys Arg Asn Ala Leu Arg Ala 
385                 390                 395                 400 


Ala Glu Val Trp Met Asp Asp Phe Lys Ser His Val Tyr Met Ala Trp 
                405                 410                 415     


Asn Ile Pro Met Ser Asn Pro Gly Val Asp Phe Gly Asp Val Ser Glu 
            420                 425                 430         


Arg Leu Ala Leu Arg Gln Arg Leu Lys Cys Arg Ser Phe Lys Trp Tyr 
        435                 440                 445             


Leu Glu Asn Val Tyr Pro Glu Met Arg Val Tyr Asn Asn Thr Leu Thr 
    450                 455                 460                 


Tyr Gly Glu Val Arg Asn Ser Lys Ala Ser Ala Tyr Cys Leu Asp Gln 
465                 470                 475                 480 


Gly Ala Glu Asp Gly Asp Arg Ala Ile Leu Tyr Pro Cys His Gly Met 
                485                 490                 495     


Ser Ser Gln Leu Val Arg Tyr Ser Ala Asp Gly Leu Leu Gln Leu Gly 
            500                 505                 510         


Pro Leu Gly Ser Thr Ala Phe Leu Pro Asp Ser Lys Cys Leu Val Asp 
        515                 520                 525             


Asp Gly Thr Gly Arg Met Pro Thr Leu Lys Lys Cys Glu Asp Val Ala 
    530                 535                 540                 


Arg Pro Thr Gln Arg Leu Trp Asp Phe Thr Gln Ser Gly Pro Ile Val 
545                 550                 555                 560 


Ser Arg Ala Thr Gly Arg Cys Leu Glu Val Glu Met Ser Lys Asp Ala 
                565                 570                 575     


Asn Phe Gly Leu Arg Leu Val Val Gln Arg Cys Ser Gly Gln Lys Trp 
            580                 585                 590         


Met Ile Arg Asn Trp Ile Lys His Ala Arg His 
        595                 600             


<210>  4325
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALNTL6__Homo_sapiens__NP_001030017

<400>  4325

Met Lys Arg Lys Gln Lys Arg Phe Leu Gln Met Thr Leu Leu Phe Thr 
1               5                   10                  15      


Val Ala Leu Ile Phe Leu Pro Asn Val Gly Leu Trp Ser Leu Tyr Lys 
            20                  25                  30          


Asp Lys His Leu Val Lys Ser Ala Glu Pro Gly Glu Gln Gln Thr Phe 
        35                  40                  45              


Pro Leu Gly Leu Gly Asp Gly Gln Phe Tyr Ser Trp Thr Asp Gly Leu 
    50                  55                  60                  


Arg Arg Lys Asp Trp His Asp Tyr Glu Ser Ile Gln Lys Glu Ala Met 
65                  70                  75                  80  


Arg Ser Gly Lys Gly Glu His Gly Lys Pro Tyr Pro Leu Thr Glu Glu 
                85                  90                  95      


Asp His Asp Asp Ser Ala Tyr Arg Glu Asn Gly Phe Asn Ile Phe Val 
            100                 105                 110         


Ser Asn Asn Ile Ala Leu Glu Arg Ser Leu Pro Asp Ile Arg His Ala 
        115                 120                 125             


Asn Cys Lys His Lys Met Tyr Leu Glu Arg Leu Pro Asn Thr Ser Ile 
    130                 135                 140                 


Ile Ile Pro Phe His Asn Glu Gly Trp Thr Ser Leu Leu Arg Thr Ile 
145                 150                 155                 160 


His Ser Ile Ile Asn Arg Thr Pro Gly Ser Leu Ile Ala Glu Ile Ile 
                165                 170                 175     


Leu Val Asp Asp Phe Ser Glu Arg Glu His Leu Lys Asp Lys Leu Glu 
            180                 185                 190         


Glu Tyr Met Ala Arg Phe Ser Lys Val Arg Ile Val Arg Thr Lys Lys 
        195                 200                 205             


Arg Glu Gly Leu Ile Arg Thr Arg Leu Leu Gly Ala Ser Met Ala Arg 
    210                 215                 220                 


Gly Glu Val Leu Thr Phe Leu Asp Ser His Cys Glu Val Asn Val Asn 
225                 230                 235                 240 


Trp Leu Pro Pro Leu Leu Asn Gln Ile Ala Leu Asn His Lys Thr Ile 
                245                 250                 255     


Val Cys Pro Met Ile Asp Val Ile Asp His Asn His Phe Gly Tyr Glu 
            260                 265                 270         


Ala Gln Ala Gly Asp Ala Met Arg Gly Ala Phe Asp Trp Glu Met Tyr 
        275                 280                 285             


Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln Arg Ala Asp Pro Ser 
    290                 295                 300                 


Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly Leu Phe Ala Val Asp 
305                 310                 315                 320 


Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp Pro Gly Leu Glu Ile 
                325                 330                 335     


Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys Val Trp Met Cys Gly 
            340                 345                 350         


Gly Glu Met Phe Asp Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg 
        355                 360                 365             


Lys Tyr Val Pro Tyr Lys Val Pro Ser Gly Thr Ser Leu Ala Arg Asn 
    370                 375                 380                 


Leu Lys Arg Val Ala Glu Thr Trp Met Asp Glu Phe Ala Glu Tyr Ile 
385                 390                 395                 400 


Tyr Gln Arg Arg Pro Glu Tyr Arg His Leu Ser Thr Gly Asp Ile Ser 
                405                 410                 415     


Ala Gln Lys Glu Leu Arg Lys Gln Leu Lys Cys Lys Asp Phe Lys Trp 
            420                 425                 430         


Phe Met Ala Ala Val Ala Trp Asp Val Pro Lys Tyr Tyr Pro Pro Val 
        435                 440                 445             


Glu Pro Pro Pro Ala Ala Trp Gly Glu Ile Arg Asn Val Ala Ala Asn 
    450                 455                 460                 


Leu Cys Val Asp Ser Lys His Gly Ala Thr Gly Thr Glu Leu Arg Leu 
465                 470                 475                 480 


Asp Ile Cys Val Lys Asp Gly Ser Glu Arg Thr Trp Ser His Glu Gln 
                485                 490                 495     


Leu Phe Thr Phe Gly Trp Arg Glu Asp Ile Arg Pro Gly Glu Pro Leu 
            500                 505                 510         


His Thr Arg Lys Phe Cys Phe Asp Ala Ile Ser His Asn Ser Pro Val 
        515                 520                 525             


Thr Leu Tyr Asp Cys His Gly Met Lys Gly Asn Gln Leu Trp Gly Tyr 
    530                 535                 540                 


Arg Lys Asp Arg Thr Leu Phe His Pro Val Ser Asn Ser Cys Met Asp 
545                 550                 555                 560 


Cys Asn Pro Ala Glu Lys Lys Ile Phe Met Ala Arg Cys Asp Pro Leu 
                565                 570                 575     


Ser Glu Thr Gln Gln Trp Ile Phe Glu His Ile Asn Met Thr Val Leu 
            580                 585                 590         


Glu Lys Phe Asn His His Ala Asn Ser 
        595                 600     


<210>  4326
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALP__Homo_sapiens__NP_001139018

<400>  4326

Met Ala Pro Pro Ser Val Pro Leu Val Leu Leu Leu Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Ala Glu Thr Pro Ala Ser Ala Pro Ala His Arg Ser Ser Thr 
            20                  25                  30          


Phe Pro Lys Trp Val Thr Lys Thr Glu Arg Gly Arg Gln Pro Leu Arg 
        35                  40                  45              


Ser 
    


<210>  4327
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALR1__Homo_sapiens__NP_001471

<400>  4327

Met Glu Leu Ala Val Gly Asn Leu Ser Glu Gly Asn Ala Ser Trp Pro 
1               5                   10                  15      


Glu Pro Pro Ala Pro Glu Pro Gly Pro Leu Phe Gly Ile Gly Val Glu 
            20                  25                  30          


Asn Phe Val Thr Leu Val Val Phe Gly Leu Ile Phe Ala Leu Gly Val 
        35                  40                  45              


Leu Gly Asn Ser Leu Val Ile Thr Val Leu Ala Arg Ser Lys Pro Gly 
    50                  55                  60                  


Lys Pro Arg Ser Thr Thr Asn Leu Phe Ile Leu Asn Leu Ser Ile Ala 
65                  70                  75                  80  


Asp Leu Ala Tyr Leu Leu Phe Cys Ile Pro Phe Gln Ala Thr Val Tyr 
                85                  90                  95      


Ala Leu Pro Thr Trp Val Leu Gly Ala Phe Ile Cys Lys Phe Ile His 
            100                 105                 110         


Tyr Phe Phe Thr Val Ser Met Leu Val Ser Ile Phe Thr Leu Ala Ala 
        115                 120                 125             


Met Ser Val Asp Arg Tyr Val Ala Ile Val His Ser Arg Arg Ser Ser 
    130                 135                 140                 


Ser Leu Arg Val Ser Arg Asn Ala Leu Leu Gly Val Gly Cys Ile Trp 
145                 150                 155                 160 


Ala Leu Ser Ile Ala Met Ala Ser Pro Val Ala Tyr His Gln Gly Leu 
                165                 170                 175     


Phe His Pro Arg Ala Ser Asn Gln Thr Phe Cys Trp Glu Gln Trp Pro 
            180                 185                 190         


Asp Pro Arg His Lys Lys Ala Tyr Val Val Cys Thr Phe Val Phe Gly 
        195                 200                 205             


Tyr Leu Leu Pro Leu Leu Leu Ile Cys Phe Cys Tyr Ala Lys Val Leu 
    210                 215                 220                 


Asn His Leu His Lys Lys Leu Lys Asn Met Ser Lys Lys Ser Glu Ala 
225                 230                 235                 240 


Ser Lys Lys Lys Thr Ala Gln Thr Val Leu Val Val Val Val Val Phe 
                245                 250                 255     


Gly Ile Ser Trp Leu Pro His His Ile Ile His Leu Trp Ala Glu Phe 
            260                 265                 270         


Gly Val Phe Pro Leu Thr Pro Ala Ser Phe Leu Phe Arg Ile Thr Ala 
        275                 280                 285             


His Cys Leu Ala Tyr Ser Asn Ser Ser Val Asn Pro Ile Ile Tyr Ala 
    290                 295                 300                 


Phe Leu Ser Glu Asn Phe Arg Lys Ala Tyr Lys Gln Val Phe Lys Cys 
305                 310                 315                 320 


His Ile Arg Lys Asp Ser His Leu Ser Asp Thr Lys Glu Ser Lys Ser 
                325                 330                 335     


Arg Ile Asp Thr Pro Pro Ser Thr Asn Cys Thr His Val 
            340                 345                 


<210>  4328
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALR2__Homo_sapiens__NP_003848

<400>  4328

Met Asn Val Ser Gly Cys Pro Gly Ala Gly Asn Ala Ser Gln Ala Gly 
1               5                   10                  15      


Gly Gly Gly Gly Trp His Pro Glu Ala Val Ile Val Pro Leu Leu Phe 
            20                  25                  30          


Ala Leu Ile Phe Leu Val Gly Thr Val Gly Asn Thr Leu Val Leu Ala 
        35                  40                  45              


Val Leu Leu Arg Gly Gly Gln Ala Val Ser Thr Thr Asn Leu Phe Ile 
    50                  55                  60                  


Leu Asn Leu Gly Val Ala Asp Leu Cys Phe Ile Leu Cys Cys Val Pro 
65                  70                  75                  80  


Phe Gln Ala Thr Ile Tyr Thr Leu Asp Gly Trp Val Phe Gly Ser Leu 
                85                  90                  95      


Leu Cys Lys Ala Val His Phe Leu Ile Phe Leu Thr Met His Ala Ser 
            100                 105                 110         


Ser Phe Thr Leu Ala Ala Val Ser Leu Asp Arg Tyr Leu Ala Ile Arg 
        115                 120                 125             


Tyr Pro Leu His Ser Arg Glu Leu Arg Thr Pro Arg Asn Ala Leu Ala 
    130                 135                 140                 


Ala Ile Gly Leu Ile Trp Gly Leu Ser Leu Leu Phe Ser Gly Pro Tyr 
145                 150                 155                 160 


Leu Ser Tyr Tyr Arg Gln Ser Gln Leu Ala Asn Leu Thr Val Cys His 
                165                 170                 175     


Pro Ala Trp Ser Ala Pro Arg Arg Arg Ala Met Asp Ile Cys Thr Phe 
            180                 185                 190         


Val Phe Ser Tyr Leu Leu Pro Val Leu Val Leu Gly Leu Thr Tyr Ala 
        195                 200                 205             


Arg Thr Leu Arg Tyr Leu Trp Arg Ala Val Asp Pro Val Ala Ala Gly 
    210                 215                 220                 


Ser Gly Ala Arg Arg Ala Lys Arg Lys Val Thr Arg Met Ile Leu Ile 
225                 230                 235                 240 


Val Ala Ala Leu Phe Cys Leu Cys Trp Met Pro His His Ala Leu Ile 
                245                 250                 255     


Leu Cys Val Trp Phe Gly Gln Phe Pro Leu Thr Arg Ala Thr Tyr Ala 
            260                 265                 270         


Leu Arg Ile Leu Ser His Leu Val Ser Tyr Ala Asn Ser Cys Val Asn 
        275                 280                 285             


Pro Ile Val Tyr Ala Leu Val Ser Lys His Phe Arg Lys Gly Phe Arg 
    290                 295                 300                 


Thr Ile Cys Ala Gly Leu Leu Gly Arg Ala Pro Gly Arg Ala Ser Gly 
305                 310                 315                 320 


Arg Val Cys Ala Ala Ala Arg Gly Thr His Ser Gly Ser Val Leu Glu 
                325                 330                 335     


Arg Glu Ser Ser Asp Leu Leu His Met Ser Glu Ala Ala Gly Ala Leu 
            340                 345                 350         


Arg Pro Cys Pro Gly Ala Ser Gln Pro Cys Ile Leu Glu Pro Cys Pro 
        355                 360                 365             


Gly Pro Ser Trp Gln Gly Pro Lys Ala Gly Asp Ser Ile Leu Thr Val 
    370                 375                 380                 


Asp Val Ala 
385         


<210>  4329
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALR3__Homo_sapiens__XP_011528770

<400>  4329

Met Ala Asp Ala Gln Asn Ile Ser Leu Asp Ser Pro Gly Ser Val Gly 
1               5                   10                  15      


Ala Val Ala Val Pro Val Val Phe Ala Leu Ile Phe Leu Leu Gly Thr 
            20                  25                  30          


Val Gly Asn Gly Leu Val Leu Ala Val Leu Leu Gln Pro Gly Pro Ser 
        35                  40                  45              


Ala Trp Gln Glu Pro Gly Ser Thr Thr Asp Leu Phe Ile Leu Asn Leu 
    50                  55                  60                  


Ala Val Ala Asp Leu Cys Phe Ile Leu Cys Cys Val Pro Phe Gln Ala 
65                  70                  75                  80  


Thr Ile Tyr Thr Leu Asp Ala Trp Leu Phe Gly Ala Leu Val Cys Lys 
                85                  90                  95      


Ala Val His Leu Leu Ile Tyr Leu Thr Met Tyr Ala Ser Ser Phe Thr 
            100                 105                 110         


Leu Ala Ala Val Ser Val Asp Arg Tyr Leu Ala Val Arg His Pro Leu 
        115                 120                 125             


Arg Ser Arg Ala Leu Arg Thr Pro Arg Asn Ala Arg Ala Ala Val Gly 
    130                 135                 140                 


Leu Val Trp Leu Leu Ala Ala Leu Phe Ser Ala Pro Tyr Leu Ser Tyr 
145                 150                 155                 160 


Tyr Gly Thr Val Arg Tyr Gly Ala Leu Glu Leu Cys Val Pro Ala Trp 
                165                 170                 175     


Glu Asp Ala Arg Arg Arg Ala Leu Asp Val Ala Thr Phe Ala Ala Gly 
            180                 185                 190         


Tyr Leu Leu Pro Val Ala Val Val Ser Leu Ala Tyr Gly Arg Thr Leu 
        195                 200                 205             


Arg Phe Leu Trp Ala Ala Val Gly Pro Ala Gly Ala Ala Ala Ala Glu 
    210                 215                 220                 


Ala Arg Arg Arg Ala Thr Gly Arg Ala Gly Arg Ala Met Leu Ala Val 
225                 230                 235                 240 


Ala Ala Leu Tyr Ala Leu Cys Trp Gly Pro His His Ala Leu Ile Leu 
                245                 250                 255     


Cys Phe Trp Tyr Gly Arg Phe Ala Phe Ser Pro Ala Thr Tyr Ala Cys 
            260                 265                 270         


Arg Leu Ala Ser His Cys Leu Ala Tyr Ala Asn Ser Cys Leu Asn Pro 
        275                 280                 285             


Leu Val Tyr Ala Leu Ala Ser Arg His Phe Arg Ala Arg Phe Arg Arg 
    290                 295                 300                 


Leu Trp Pro Cys Gly Arg Arg Arg Arg His Arg Ala Arg Arg Ala Leu 
305                 310                 315                 320 


Arg Arg Val Arg Pro Ala Ser Ser Gly Pro Pro Gly Cys Pro Gly Asp 
                325                 330                 335     


Ala Arg Pro Ser Gly Arg Leu Leu Ala Gly Gly Gly Gln Gly Pro Glu 
            340                 345                 350         


Pro Arg Glu Gly Pro Val His Gly Gly Glu Ala Ala Arg Gly Pro Glu 
        355                 360                 365             


<210>  4330
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALT__Homo_sapiens__NP_000146

<400>  4330

Met Ser Arg Ser Gly Thr Asp Pro Gln Gln Arg Gln Gln Ala Ser Glu 
1               5                   10                  15      


Ala Asp Ala Ala Ala Ala Thr Phe Arg Ala Asn Asp His Gln His Ile 
            20                  25                  30          


Arg Tyr Asn Pro Leu Gln Asp Glu Trp Val Leu Val Ser Ala His Arg 
        35                  40                  45              


Met Lys Arg Pro Trp Gln Gly Gln Val Glu Pro Gln Leu Leu Lys Thr 
    50                  55                  60                  


Val Pro Arg His Asp Pro Leu Asn Pro Leu Cys Pro Gly Ala Ile Arg 
65                  70                  75                  80  


Ala Asn Gly Glu Val Asn Pro Gln Tyr Asp Ser Thr Phe Leu Phe Asp 
                85                  90                  95      


Asn Asp Phe Pro Ala Leu Gln Pro Asp Ala Pro Ser Pro Gly Pro Ser 
            100                 105                 110         


Asp His Pro Leu Phe Gln Ala Lys Ser Ala Arg Gly Val Cys Lys Val 
        115                 120                 125             


Met Cys Phe His Pro Trp Ser Asp Val Thr Leu Pro Leu Met Ser Val 
    130                 135                 140                 


Pro Glu Ile Arg Ala Val Val Asp Ala Trp Ala Ser Val Thr Glu Glu 
145                 150                 155                 160 


Leu Gly Ala Gln Tyr Pro Trp Val Gln Ile Phe Glu Asn Lys Gly Ala 
                165                 170                 175     


Met Met Gly Cys Ser Asn Pro His Pro His Cys Gln Val Trp Ala Ser 
            180                 185                 190         


Ser Phe Leu Pro Asp Ile Ala Gln Arg Glu Glu Arg Ser Gln Gln Ala 
        195                 200                 205             


Tyr Lys Ser Gln His Gly Glu Pro Leu Leu Met Glu Tyr Ser Arg Gln 
    210                 215                 220                 


Glu Leu Leu Arg Lys Glu Arg Leu Val Leu Thr Ser Glu His Trp Leu 
225                 230                 235                 240 


Val Leu Val Pro Phe Trp Ala Thr Trp Pro Tyr Gln Thr Leu Leu Leu 
                245                 250                 255     


Pro Arg Arg His Val Arg Arg Leu Pro Glu Leu Thr Pro Ala Glu Arg 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Met Lys Lys Leu Leu Thr Lys Tyr Asp Asn 
        275                 280                 285             


Leu Phe Glu Thr Ser Phe Pro Tyr Ser Met Gly Trp His Gly Ala Pro 
    290                 295                 300                 


Thr Gly Ser Glu Ala Gly Ala Asn Trp Asn His Trp Gln Leu His Ala 
305                 310                 315                 320 


His Tyr Tyr Pro Pro Leu Leu Arg Ser Ala Thr Val Arg Lys Phe Met 
                325                 330                 335     


Val Gly Tyr Glu Met Leu Ala Gln Ala Gln Arg Asp Leu Thr Pro Glu 
            340                 345                 350         


Gln Ala Ala Glu Arg Leu Arg Ala Leu Pro Glu Val His Tyr His Leu 
        355                 360                 365             


Gly Gln Lys Asp Arg Glu Thr Ala Thr Ile Ala 
    370                 375                 


<210>  4331
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAMT__Homo_sapiens__NP_000147

<400>  4331

Met Ser Ala Pro Ser Ala Thr Pro Ile Phe Ala Pro Gly Glu Asn Cys 
1               5                   10                  15      


Ser Pro Ala Trp Gly Ala Ala Pro Ala Ala Tyr Asp Ala Ala Asp Thr 
            20                  25                  30          


His Leu Arg Ile Leu Gly Lys Pro Val Met Glu Arg Trp Glu Thr Pro 
        35                  40                  45              


Tyr Met His Ala Leu Ala Ala Ala Ala Ser Ser Lys Gly Gly Arg Val 
    50                  55                  60                  


Leu Glu Val Gly Phe Gly Met Ala Ile Ala Ala Ser Lys Val Gln Glu 
65                  70                  75                  80  


Ala Pro Ile Asp Glu His Trp Ile Ile Glu Cys Asn Asp Gly Val Phe 
                85                  90                  95      


Gln Arg Leu Arg Asp Trp Ala Pro Arg Gln Thr His Lys Val Ile Pro 
            100                 105                 110         


Leu Lys Gly Leu Trp Glu Asp Val Ala Pro Thr Leu Pro Asp Gly His 
        115                 120                 125             


Phe Asp Gly Ile Leu Tyr Asp Thr Tyr Pro Leu Ser Glu Glu Thr Trp 
    130                 135                 140                 


His Thr His Gln Phe Asn Phe Ile Lys Asn His Ala Phe Arg Leu Leu 
145                 150                 155                 160 


Lys Pro Gly Gly Val Leu Thr Tyr Cys Asn Leu Thr Ser Trp Gly Glu 
                165                 170                 175     


Leu Met Lys Ser Lys Tyr Ser Asp Ile Thr Ile Met Phe Glu Glu Thr 
            180                 185                 190         


Gln Val Pro Ala Leu Leu Glu Ala Gly Phe Arg Arg Glu Asn Ile Arg 
        195                 200                 205             


Thr Glu Val Met Ala Leu Val Pro Pro Ala Asp Cys Arg Tyr Tyr Ala 
    210                 215                 220                 


Phe Pro Gln Met Ile Thr Pro Leu Val Thr Lys Gly 
225                 230                 235     


<210>  4332
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GANAB__Homo_sapiens__NP_001265123

<400>  4332

Met Thr Arg Phe Arg Ile Asp Glu Leu Glu Pro Arg Arg Pro Arg Tyr 
1               5                   10                  15      


Arg Val Pro Asp Val Leu Val Ala Asp Pro Pro Ile Ala Arg Leu Ser 
            20                  25                  30          


Val Ser Gly Arg Asp Glu Asn Ser Val Glu Leu Thr Met Ala Glu Gly 
        35                  40                  45              


Pro Tyr Lys Ile Ile Leu Thr Ala Arg Pro Phe Arg Leu Asp Leu Leu 
    50                  55                  60                  


Glu Asp Arg Ser Leu Leu Leu Ser Val Asn Ala Arg Gly Leu Leu Glu 
65                  70                  75                  80  


Phe Glu His Gln Arg Ala Pro Arg Val Ser Gln Gly Ser Lys Asp Pro 
                85                  90                  95      


Ala Glu Gly Asp Gly Ala Gln Pro Glu Glu Thr Pro Arg Asp Gly Asp 
            100                 105                 110         


Lys Pro Glu Glu Thr Gln Gly Lys Ala Glu Lys Asp Glu Pro Gly Ala 
        115                 120                 125             


Trp Glu Glu Thr Phe Lys Thr His Ser Asp Ser Lys Pro Tyr Gly Pro 
    130                 135                 140                 


Met Ser Val Gly Leu Asp Phe Ser Leu Pro Gly Met Glu His Val Tyr 
145                 150                 155                 160 


Gly Ile Pro Glu His Ala Asp Asn Leu Arg Leu Lys Val Thr Glu Gly 
                165                 170                 175     


Gly Glu Pro Tyr Arg Leu Tyr Asn Leu Asp Val Phe Gln Tyr Glu Leu 
            180                 185                 190         


Tyr Asn Pro Met Ala Leu Tyr Gly Ser Val Pro Val Leu Leu Ala His 
        195                 200                 205             


Asn Pro His Arg Asp Leu Gly Ile Phe Trp Leu Asn Ala Ala Glu Thr 
    210                 215                 220                 


Trp Val Asp Ile Ser Ser Asn Thr Ala Gly Lys Thr Leu Phe Gly Lys 
225                 230                 235                 240 


Met Met Asp Tyr Leu Gln Gly Ser Gly Glu Thr Pro Gln Thr Asp Val 
                245                 250                 255     


Arg Trp Met Ser Glu Thr Gly Ile Ile Asp Val Phe Leu Leu Leu Gly 
            260                 265                 270         


Pro Ser Ile Ser Asp Val Phe Arg Gln Tyr Ala Ser Leu Thr Gly Thr 
        275                 280                 285             


Gln Ala Leu Pro Pro Leu Phe Ser Leu Gly Tyr His Gln Ser Arg Trp 
    290                 295                 300                 


Asn Tyr Arg Asp Glu Ala Asp Val Leu Glu Val Asp Gln Gly Phe Asp 
305                 310                 315                 320 


Asp His Asn Leu Pro Cys Asp Val Ile Trp Leu Asp Ile Glu His Ala 
                325                 330                 335     


Asp Gly Lys Arg Tyr Phe Thr Trp Asp Pro Ser Arg Phe Pro Gln Pro 
            340                 345                 350         


Arg Thr Met Leu Glu Arg Leu Ala Ser Lys Arg Arg Lys Leu Val Ala 
        355                 360                 365             


Ile Val Asp Pro His Ile Lys Val Asp Ser Gly Tyr Arg Val His Glu 
    370                 375                 380                 


Glu Leu Arg Asn Leu Gly Leu Tyr Val Lys Thr Arg Asp Gly Ser Asp 
385                 390                 395                 400 


Tyr Glu Gly Trp Cys Trp Pro Gly Ser Ala Gly Tyr Pro Asp Phe Thr 
                405                 410                 415     


Asn Pro Thr Met Arg Ala Trp Trp Ala Asn Met Phe Ser Tyr Asp Asn 
            420                 425                 430         


Tyr Glu Gly Ser Ala Pro Asn Leu Phe Val Trp Asn Asp Met Asn Glu 
        435                 440                 445             


Pro Ser Val Phe Asn Gly Pro Glu Val Thr Met Leu Lys Asp Ala Gln 
    450                 455                 460                 


His Tyr Gly Gly Trp Glu His Arg Asp Val His Asn Ile Tyr Gly Leu 
465                 470                 475                 480 


Tyr Val His Met Ala Thr Ala Asp Gly Leu Arg Gln Arg Ser Gly Gly 
                485                 490                 495     


Met Glu Arg Pro Phe Val Leu Ala Arg Ala Phe Phe Ala Gly Ser Gln 
            500                 505                 510         


Arg Phe Gly Ala Val Trp Thr Gly Asp Asn Thr Ala Glu Trp Asp His 
        515                 520                 525             


Leu Lys Ile Ser Ile Pro Met Cys Leu Ser Leu Gly Leu Val Gly Leu 
    530                 535                 540                 


Ser Phe Cys Gly Ala Asp Val Gly Gly Phe Phe Lys Asn Pro Glu Pro 
545                 550                 555                 560 


Glu Leu Leu Val Arg Trp Tyr Gln Met Gly Ala Tyr Gln Pro Phe Phe 
                565                 570                 575     


Arg Ala His Ala His Leu Asp Thr Gly Arg Arg Glu Pro Trp Leu Leu 
            580                 585                 590         


Pro Ser Gln His Asn Asp Ile Ile Arg Asp Ala Leu Gly Gln Arg Tyr 
        595                 600                 605             


Ser Leu Leu Pro Phe Trp Tyr Thr Leu Leu Tyr Gln Ala His Arg Glu 
    610                 615                 620                 


Gly Ile Pro Val Met Arg Pro Leu Trp Val Gln Tyr Pro Gln Asp Val 
625                 630                 635                 640 


Thr Thr Phe Asn Ile Asp Asp Gln Tyr Leu Leu Gly Asp Ala Leu Leu 
                645                 650                 655     


Val His Pro Val Ser Asp Ser Gly Ala His Gly Val Gln Val Tyr Leu 
            660                 665                 670         


Pro Gly Gln Gly Glu Val Trp Tyr Asp Ile Gln Ser Tyr Gln Lys His 
        675                 680                 685             


His Gly Pro Gln Thr Leu Tyr Leu Pro Val Thr Leu Ser Ser Ile Pro 
    690                 695                 700                 


Val Phe Gln Arg Gly Gly Thr Ile Val Pro Arg Trp Met Arg Val Arg 
705                 710                 715                 720 


Arg Ser Ser Glu Cys Met Lys Asp Asp Pro Ile Thr Leu Phe Val Ala 
                725                 730                 735     


Leu Ser Pro Gln Gly Thr Ala Gln Gly Glu Leu Phe Leu Asp Asp Gly 
            740                 745                 750         


His Thr Phe Asn Tyr Gln Thr Arg Gln Glu Phe Leu Leu Arg Arg Phe 
        755                 760                 765             


Ser Phe Ser Gly Asn Thr Leu Val Ser Ser Ser Ala Asp Pro Glu Gly 
    770                 775                 780                 


His Phe Glu Thr Pro Ile Trp Ile Glu Arg Val Val Ile Ile Gly Ala 
785                 790                 795                 800 


Gly Lys Pro Ala Ala Val Val Leu Gln Thr Lys Gly Ser Pro Glu Ser 
                805                 810                 815     


Arg Leu Ser Phe Gln His Asp Pro Glu Thr Ser Val Leu Val Leu Arg 
            820                 825                 830         


Lys Pro Gly Ile Asn Val Ala Ser Asp Trp Ser Ile His Leu Arg 
        835                 840                 845         


<210>  4333
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GANC__Homo_sapiens__NP_001288339

<400>  4333

Met Glu Ala Ala Val Lys Glu Glu Ile Ser Leu Glu Asp Glu Ala Val 
1               5                   10                  15      


Asp Lys Asn Ile Phe Arg Asp Cys Asn Lys Ile Ala Phe Tyr Arg Arg 
            20                  25                  30          


Gln Lys Gln Trp Leu Ser Lys Lys Ser Thr Tyr Gln Ala Leu Leu Asp 
        35                  40                  45              


Ser Val Thr Thr Asp Glu Asp Ser Thr Arg Phe Gln Ile Ile Asn Glu 
    50                  55                  60                  


Ala Ser Lys Val Arg Cys Gln Asp Gln Ser Pro Thr Thr Leu Asp Ala 
65                  70                  75                  80  


Phe Lys Gly Lys Glu Thr Thr Val Gln Glu Glu Thr Gln Asp Leu Ser 
                85                  90                  95      


Thr Arg Gln His Leu Ala Gln Lys Glu Ala Glu Glu Pro Asp Lys Gln 
            100                 105                 110         


Gly Gln Ile Thr Trp Asp Ile Ser Asn Val Ala Pro Lys Thr Glu Asn 
        115                 120                 125             


Phe Glu Asp Leu Leu Glu Gln Thr Pro Cys Ser Ala Cys Leu Gln Gly 
    130                 135                 140                 


Phe Thr Arg Asp Asn Thr Ser Ser Ser Phe Ser Glu Asp Ala Gly Ile 
145                 150                 155                 160 


Ser Leu Ser Thr Ser Val Lys Leu Pro Leu Ala Ser Ser Ser Lys Pro 
                165                 170                 175     


Asn Glu Asn Glu Ala Leu Pro Asn Gln Pro Pro Ser Gln Gln Ile Arg 
            180                 185                 190         


His Asn Tyr Arg Leu Leu Ala Ser Thr Val Ser Ala Glu Met Ala Arg 
        195                 200                 205             


Asn Arg Gln Leu Ile Trp Glu Leu Ala Arg Gln Ser Glu Ala His Leu 
    210                 215                 220                 


Asp Arg Pro Val Val Leu Gly Glu Gln Ala Ser Ala Gln Arg Glu Val 
225                 230                 235                 240 


Ala Ser Ile Leu Cys Arg Lys Ser Val Leu Ala Ile Asn Gln Leu Ala 
                245                 250                 255     


Ala Thr Val Glu Gly Thr Ile Ser Val Leu Gln Gln Phe Asn Glu Leu 
            260                 265                 270         


Leu Asp His Pro Leu Asp Pro Gly Arg Ser 
        275                 280         


<210>  4334
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAN__Homo_sapiens__NP_071324

<400>  4334

Met Ala Glu Gly Ser Ala Val Ser Asp Pro Gln His Ala Ala Arg Leu 
1               5                   10                  15      


Leu Arg Ala Leu Ser Ser Phe Arg Glu Glu Ser Arg Phe Cys Asp Ala 
            20                  25                  30          


His Leu Val Leu Asp Gly Glu Glu Ile Pro Val Gln Lys Asn Ile Leu 
        35                  40                  45              


Ala Ala Ala Ser Pro Tyr Ile Arg Thr Lys Leu Asn Tyr Asn Pro Pro 
    50                  55                  60                  


Lys Asp Asp Gly Ser Thr Tyr Lys Ile Glu Leu Glu Gly Ile Ser Val 
65                  70                  75                  80  


Met Val Met Arg Glu Ile Leu Asp Tyr Ile Phe Ser Gly Gln Ile Arg 
                85                  90                  95      


Leu Asn Glu Asp Thr Ile Gln Asp Val Val Gln Ala Ala Asp Leu Leu 
            100                 105                 110         


Leu Leu Thr Asp Leu Lys Thr Leu Cys Cys Glu Phe Leu Glu Gly Cys 
        115                 120                 125             


Ile Ala Ala Glu Asn Cys Ile Gly Ile Arg Asp Phe Ala Leu His Tyr 
    130                 135                 140                 


Cys Leu His His Val His Tyr Leu Ala Thr Glu Tyr Leu Glu Thr His 
145                 150                 155                 160 


Phe Arg Asp Val Ser Ser Thr Glu Glu Phe Leu Glu Leu Ser Pro Gln 
                165                 170                 175     


Lys Leu Lys Glu Val Ile Ser Leu Glu Lys Leu Asn Val Gly Asn Glu 
            180                 185                 190         


Arg Tyr Val Phe Glu Ala Val Ile Arg Trp Ile Ala His Asp Thr Glu 
        195                 200                 205             


Ile Arg Lys Val His Met Lys Asp Val Met Ser Ala Leu Trp Val Ser 
    210                 215                 220                 


Gly Leu Asp Ser Ser Tyr Leu Arg Glu Gln Met Leu Asn Glu Pro Leu 
225                 230                 235                 240 


Val Arg Glu Ile Val Lys Glu Cys Ser Asn Ile Pro Leu Ser Gln Pro 
                245                 250                 255     


Gln Gln Gly Glu Ala Met Leu Ala Asn Phe Lys Pro Arg Gly Tyr Ser 
            260                 265                 270         


Glu Cys Ile Val Thr Val Gly Gly Glu Glu Arg Val Ser Arg Lys Pro 
        275                 280                 285             


Thr Ala Ala Met Arg Cys Met Cys Pro Leu Tyr Asp Pro Asn Arg Gln 
    290                 295                 300                 


Leu Trp Ile Glu Leu Ala Pro Leu Ser Met Pro Arg Ile Asn His Gly 
305                 310                 315                 320 


Val Leu Ser Ala Glu Gly Phe Leu Phe Val Phe Gly Gly Gln Asp Glu 
                325                 330                 335     


Asn Lys Gln Thr Leu Ser Ser Gly Glu Lys Tyr Asp Pro Asp Ala Asn 
            340                 345                 350         


Thr Trp Thr Ala Leu Pro Pro Met Asn Glu Ala Arg His Asn Phe Gly 
        355                 360                 365             


Ile Val Glu Ile Asp Gly Met Leu Tyr Ile Leu Gly Gly Glu Asp Gly 
    370                 375                 380                 


Glu Lys Glu Leu Ile Ser Met Glu Cys Tyr Asp Ile Tyr Ser Lys Thr 
385                 390                 395                 400 


Trp Thr Lys Gln Pro Asp Leu Thr Met Val Arg Lys Ile Gly Cys Tyr 
                405                 410                 415     


Ala Ala Met Lys Lys Lys Ile Tyr Ala Met Gly Gly Gly Ser Tyr Gly 
            420                 425                 430         


Lys Leu Phe Glu Ser Val Glu Cys Tyr Asp Pro Arg Thr Gln Gln Trp 
        435                 440                 445             


Thr Ala Ile Cys Pro Leu Lys Glu Arg Arg Phe Gly Ala Val Ala Cys 
    450                 455                 460                 


Gly Val Ala Met Glu Leu Tyr Val Phe Gly Gly Val Arg Ser Arg Glu 
465                 470                 475                 480 


Asp Ala Gln Gly Ser Glu Met Val Thr Cys Lys Ser Glu Phe Tyr His 
                485                 490                 495     


Asp Glu Phe Lys Arg Trp Ile Tyr Leu Asn Asp Gln Asn Leu Cys Ile 
            500                 505                 510         


Pro Ala Ser Ser Ser Phe Val Tyr Gly Ala Val Pro Ile Gly Ala Ser 
        515                 520                 525             


Ile Tyr Val Ile Gly Asp Leu Asp Thr Gly Thr Asn Tyr Asp Tyr Val 
    530                 535                 540                 


Arg Glu Phe Lys Arg Ser Thr Gly Thr Trp His His Thr Lys Pro Leu 
545                 550                 555                 560 


Leu Pro Ser Asp Leu Arg Arg Thr Gly Cys Ala Ala Leu Arg Ile Ala 
                565                 570                 575     


Asn Cys Lys Leu Phe Arg Leu Gln Leu Gln Gln Gly Leu Phe Arg Ile 
            580                 585                 590         


Arg Val His Ser Pro 
        595         


<210>  4335
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAP43__Homo_sapiens__NP_001123536

<400>  4335

Met Thr Lys Ser Cys Ser Glu Leu Cys His Pro Ala Leu His Phe Leu 
1               5                   10                  15      


Pro Cys Leu Gly Gly Leu Arg Lys Asn Leu Gln Arg Ala Val Arg Pro 
            20                  25                  30          


Ser Pro Tyr Ser Leu Gly Phe Leu Thr Phe Trp Ile Ser Arg Val Glu 
        35                  40                  45              


Lys Asn Asp Asp Asp Gln Lys Ile Glu Gln Asp Gly Ile Lys Pro Glu 
    50                  55                  60                  


Asp Lys Ala His Lys Ala Ala Thr Lys Ile Gln Ala Ser Phe Arg Gly 
65                  70                  75                  80  


His Ile Thr Arg Lys Lys Leu Lys Gly Glu Lys Lys Asp Asp Val Gln 
                85                  90                  95      


Ala Ala Glu Ala Glu Ala Asn Lys Lys Asp Glu Ala Pro Val Ala Asp 
            100                 105                 110         


Gly Val Glu Lys Lys Gly Glu Gly Thr Thr Thr Ala Glu Ala Ala Pro 
        115                 120                 125             


Ala Thr Gly Ser Lys Pro Asp Glu Pro Gly Lys Ala Gly Glu Thr Pro 
    130                 135                 140                 


Ser Glu Glu Lys Lys Gly Glu Gly Asp Ala Ala Thr Glu Gln Ala Ala 
145                 150                 155                 160 


Pro Gln Ala Pro Ala Ser Ser Glu Glu Lys Ala Gly Ser Ala Glu Thr 
                165                 170                 175     


Glu Ser Ala Thr Lys Ala Ser Thr Asp Asn Ser Pro Ser Ser Lys Ala 
            180                 185                 190         


Glu Asp Ala Pro Ala Lys Glu Glu Pro Lys Gln Ala Asp Val Pro Ala 
        195                 200                 205             


Ala Val Thr Ala Ala Ala Ala Thr Thr Pro Ala Ala Glu Asp Ala Ala 
    210                 215                 220                 


Ala Lys Ala Thr Ala Gln Pro Pro Thr Glu Thr Gly Glu Ser Ser Gln 
225                 230                 235                 240 


Ala Glu Glu Asn Ile Glu Ala Val Asp Glu Thr Lys Pro Lys Glu Ser 
                245                 250                 255     


Ala Arg Gln Asp Glu Gly Lys Glu Glu Glu Pro Glu Ala Asp Gln Glu 
            260                 265                 270         


His Ala 
        


<210>  4336
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAPDH__Homo_sapiens__NP_001243728

<400>  4336

Met Val Tyr Met Phe Gln Tyr Asp Ser Thr His Gly Lys Phe His Gly 
1               5                   10                  15      


Thr Val Lys Ala Glu Asn Gly Lys Leu Val Ile Asn Gly Asn Pro Ile 
            20                  25                  30          


Thr Ile Phe Gln Glu Arg Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala 
        35                  40                  45              


Gly Ala Glu Tyr Val Val Glu Ser Thr Gly Val Phe Thr Thr Met Glu 
    50                  55                  60                  


Lys Ala Gly Ala His Leu Gln Gly Gly Ala Lys Arg Val Ile Ile Ser 
65                  70                  75                  80  


Ala Pro Ser Ala Asp Ala Pro Met Phe Val Met Gly Val Asn His Glu 
                85                  90                  95      


Lys Tyr Asp Asn Ser Leu Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr 
            100                 105                 110         


Asn Cys Leu Ala Pro Leu Ala Lys Val Ile His Asp Asn Phe Gly Ile 
        115                 120                 125             


Val Glu Gly Leu Met Thr Thr Val His Ala Ile Thr Ala Thr Gln Lys 
    130                 135                 140                 


Thr Val Asp Gly Pro Ser Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala 
145                 150                 155                 160 


Leu Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala Val Gly 
                165                 170                 175     


Lys Val Ile Pro Glu Leu Asn Gly Lys Leu Thr Gly Met Ala Phe Arg 
            180                 185                 190         


Val Pro Thr Ala Asn Val Ser Val Val Asp Leu Thr Cys Arg Leu Glu 
        195                 200                 205             


Lys Pro Ala Lys Tyr Asp Asp Ile Lys Lys Val Val Lys Gln Ala Ser 
    210                 215                 220                 


Glu Gly Pro Leu Lys Gly Ile Leu Gly Tyr Thr Glu His Gln Val Val 
225                 230                 235                 240 


Ser Ser Asp Phe Asn Ser Asp Thr His Ser Ser Thr Phe Asp Ala Gly 
                245                 250                 255     


Ala Gly Ile Ala Leu Asn Asp His Phe Val Lys Leu Ile Ser Trp Tyr 
            260                 265                 270         


Asp Asn Glu Phe Gly Tyr Ser Asn Arg Val Val Asp Leu Met Ala His 
        275                 280                 285             


Met Ala Ser Lys Glu 
    290             


<210>  4337
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAPDHS__Homo_sapiens__NP_055179

<400>  4337

Met Ser Lys Arg Asp Ile Val Leu Thr Asn Val Thr Val Val Gln Leu 
1               5                   10                  15      


Leu Arg Gln Pro Cys Pro Val Thr Arg Ala Pro Pro Pro Pro Glu Pro 
            20                  25                  30          


Lys Ala Glu Val Glu Pro Gln Pro Gln Pro Glu Pro Thr Pro Val Arg 
        35                  40                  45              


Glu Glu Ile Lys Pro Pro Pro Pro Pro Leu Pro Pro His Pro Ala Thr 
    50                  55                  60                  


Pro Pro Pro Lys Met Val Ser Val Ala Arg Glu Leu Thr Val Gly Ile 
65                  70                  75                  80  


Asn Gly Phe Gly Arg Ile Gly Arg Leu Val Leu Arg Ala Cys Met Glu 
                85                  90                  95      


Lys Gly Val Lys Val Val Ala Val Asn Asp Pro Phe Ile Asp Pro Glu 
            100                 105                 110         


Tyr Met Val Tyr Met Phe Lys Tyr Asp Ser Thr His Gly Arg Tyr Lys 
        115                 120                 125             


Gly Ser Val Glu Phe Arg Asn Gly Gln Leu Val Val Asp Asn His Glu 
    130                 135                 140                 


Ile Ser Val Tyr Gln Cys Lys Glu Pro Lys Gln Ile Pro Trp Arg Ala 
145                 150                 155                 160 


Val Gly Ser Pro Tyr Val Val Glu Ser Thr Gly Val Tyr Leu Ser Ile 
                165                 170                 175     


Gln Ala Ala Ser Asp His Ile Ser Ala Gly Ala Gln Arg Val Val Ile 
            180                 185                 190         


Ser Ala Pro Ser Pro Asp Ala Pro Met Phe Val Met Gly Val Asn Glu 
        195                 200                 205             


Asn Asp Tyr Asn Pro Gly Ser Met Asn Ile Val Ser Asn Ala Ser Cys 
    210                 215                 220                 


Thr Thr Asn Cys Leu Ala Pro Leu Ala Lys Val Ile His Glu Arg Phe 
225                 230                 235                 240 


Gly Ile Val Glu Gly Leu Met Thr Thr Val His Ser Tyr Thr Ala Thr 
                245                 250                 255     


Gln Lys Thr Val Asp Gly Pro Ser Arg Lys Ala Trp Arg Asp Gly Arg 
            260                 265                 270         


Gly Ala His Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala Ala Lys Ala 
        275                 280                 285             


Val Thr Lys Val Ile Pro Glu Leu Lys Gly Lys Leu Thr Gly Met Ala 
    290                 295                 300                 


Phe Arg Val Pro Thr Pro Asp Val Ser Val Val Asp Leu Thr Cys Arg 
305                 310                 315                 320 


Leu Ala Gln Pro Ala Pro Tyr Ser Ala Ile Lys Glu Ala Val Lys Ala 
                325                 330                 335     


Ala Ala Lys Gly Pro Met Ala Gly Ile Leu Ala Tyr Thr Glu Asp Glu 
            340                 345                 350         


Val Val Ser Thr Asp Phe Leu Gly Asp Thr His Ser Ser Ile Phe Asp 
        355                 360                 365             


Ala Lys Ala Gly Ile Ala Leu Asn Asp Asn Phe Val Lys Leu Ile Ser 
    370                 375                 380                 


Trp Tyr Asp Asn Glu Tyr Gly Tyr Ser His Arg Val Val Asp Leu Leu 
385                 390                 395                 400 


Arg Tyr Met Phe Ser Arg Asp Lys 
                405             


<210>  4338
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAR1__Homo_sapiens__NP_061856

<400>  4338

Met Ser Phe Arg Gly Gly Gly Arg Gly Gly Phe Asn Arg Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Phe Asn Arg Gly Gly Ser Ser Asn His Phe Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Asn Phe Arg Gly Gly Gly Arg Gly Gly 
        35                  40                  45              


Phe Gly Arg Gly Gly Gly Arg Gly Gly Phe Asn Lys Gly Gln Asp Gln 
    50                  55                  60                  


Gly Pro Pro Glu Arg Val Val Leu Leu Gly Glu Phe Leu His Pro Cys 
65                  70                  75                  80  


Glu Asp Asp Ile Val Cys Lys Cys Thr Thr Asp Glu Asn Lys Val Pro 
                85                  90                  95      


Tyr Phe Asn Ala Pro Val Tyr Leu Glu Asn Lys Glu Gln Ile Gly Lys 
            100                 105                 110         


Val Asp Glu Ile Phe Gly Gln Leu Arg Asp Phe Tyr Phe Ser Val Lys 
        115                 120                 125             


Leu Ser Glu Asn Met Lys Ala Ser Ser Phe Lys Lys Leu Gln Lys Phe 
    130                 135                 140                 


Tyr Ile Asp Pro Tyr Lys Leu Leu Pro Leu Gln Arg Phe Leu Pro Arg 
145                 150                 155                 160 


Pro Pro Gly Glu Lys Gly Pro Pro Arg Gly Gly Gly Arg Gly Gly Arg 
                165                 170                 175     


Gly Gly Gly Arg Gly Gly Gly Gly Arg Gly Gly Gly Arg Gly Gly Gly 
            180                 185                 190         


Phe Arg Gly Gly Arg Gly Gly Gly Gly Gly Gly Phe Arg Gly Gly Arg 
        195                 200                 205             


Gly Gly Gly Phe Arg Gly Arg Gly His 
    210                 215         


<210>  4339
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAREM__Homo_sapiens__NP_001229338

<400>  4339

Met Asp Pro Ala Pro Ser Leu Gly Cys Ser Leu Lys Asp Val Lys Trp 
1               5                   10                  15      


Ser Ser Val Ala Val Pro Leu Asp Leu Leu Val Ser Thr Tyr Arg Leu 
            20                  25                  30          


Pro Gln Ile Ala Arg Leu Asp Asn Gly Glu Cys Val Glu Gly Leu Arg 
        35                  40                  45              


Glu Asn Asp Tyr Leu Leu Ile His Ser Cys Arg Gln Trp Thr Thr Ile 
    50                  55                  60                  


Thr Ala His Ser Leu Glu Glu Gly His Tyr Val Ile Gly Pro Lys Ile 
65                  70                  75                  80  


Glu Ile Pro Val His Tyr Ala Gly Gln Phe Lys Leu Leu Glu Gln Asp 
                85                  90                  95      


Arg Asp Ile Lys Glu Pro Val Gln Tyr Phe Asn Ser Val Glu Glu Val 
            100                 105                 110         


Ala Lys Ala Phe Pro Glu Arg Val Tyr Val Met Glu Asp Ile Thr Phe 
        115                 120                 125             


Asn Val Lys Val Ala Ser Gly Glu Cys Asn Glu Asp Thr Glu Val Tyr 
    130                 135                 140                 


Asn Ile Thr Leu Cys Thr Gly Asp Glu Leu Thr Leu Met Gly Gln Ala 
145                 150                 155                 160 


Glu Ile Leu Tyr Ala Lys Thr Phe Lys Glu Lys Ser Arg Leu Asn Thr 
                165                 170                 175     


Ile Phe Lys Lys Ile Gly Lys Leu Asn Ser Ile Ser Lys Leu Gly Lys 
            180                 185                 190         


Gly Lys Met Pro Cys Leu Ile Cys Met Asn His Arg Thr Asn Glu Ser 
        195                 200                 205             


Ile Ser Leu Pro Phe Gln Cys Lys Gly Arg Phe Ser Thr Arg Ser Pro 
    210                 215                 220                 


Leu Glu Leu Gln Met Gln Glu Gly Glu His Thr Ile Arg Asn Ile Val 
225                 230                 235                 240 


Glu Lys Thr Arg Leu Pro Val Asn Val Thr Val Pro Ser Pro Pro Pro 
                245                 250                 255     


Arg Asn Pro Tyr Asp Leu His Phe Ile Arg Glu Gly His Arg Tyr Lys 
            260                 265                 270         


Phe Val Asn Ile Gln Thr Lys Thr Val Val Val Cys Cys Val Leu Arg 
        275                 280                 285             


Asn Asn Lys Ile Leu Pro Met His Phe Pro Leu His Leu Thr Val Pro 
    290                 295                 300                 


Lys Phe Ser Leu Pro Glu His Leu Val Lys Gly Glu Ser Trp Pro Glu 
305                 310                 315                 320 


Thr Leu Val His His Trp Leu Gly Ile Cys Gln Glu Gln Phe Asp Ile 
                325                 330                 335     


Asp Glu Tyr Ser Arg Ala Val Arg Asp Val Lys Thr Asp Trp Asn Glu 
            340                 345                 350         


Glu Cys Lys Ser Pro Lys Lys Gly Arg Cys Ser Gly His Asn His Val 
        355                 360                 365             


Pro Asn Ser Leu Ser Tyr Ala Arg Asp Glu Leu Thr Gln Ser Phe His 
    370                 375                 380                 


Arg Leu Ser Val Cys Val Tyr Gly Asn Asn Leu His Gly Asn Ser Glu 
385                 390                 395                 400 


Val Asn Leu His Gly Cys Arg Asp Leu Gly Gly Asp Trp Ala Pro Phe 
                405                 410                 415     


Pro His Asp Ile Leu Pro Tyr Gln Asp Ser Gly Asp Ser Gly Ser Asp 
            420                 425                 430         


Tyr Leu Phe Pro Glu Ala Ser Glu Glu Ser Ala Gly Ile Pro Gly Lys 
        435                 440                 445             


Ser Glu Leu Pro Tyr Glu Glu Leu Trp Leu Glu Glu Gly Lys Pro Ser 
    450                 455                 460                 


His Gln Pro Leu Thr Arg Ser Leu Ser Glu Lys Asn Arg Cys Asp Gln 
465                 470                 475                 480 


Phe Arg Gly Ser Val Arg Ser Lys Cys Ala Thr Ser Pro Leu Pro Ile 
                485                 490                 495     


Pro Gly Thr Leu Gly Ala Ala Val Lys Ser Ser Asp Thr Ala Leu Pro 
            500                 505                 510         


Pro Pro Pro Val Pro Pro Lys Ser Glu Ala Val Arg Glu Glu Cys Arg 
        515                 520                 525             


Leu Leu Asn Ala Pro Pro Val Pro Pro Arg Ser Ala Lys Pro Leu Ser 
    530                 535                 540                 


Thr Ser Pro Ser Ile Pro Pro Arg Thr Val Lys Pro Ala Arg Gln Gln 
545                 550                 555                 560 


Thr Arg Ser Pro Ser Pro Thr Leu Ser Tyr Tyr Ser Ser Gly Leu His 
                565                 570                 575     


Asn Ile Ser Val Thr Lys Thr Asp Thr Asn Pro Ser Glu Ser Thr Pro 
            580                 585                 590         


Val Ser Cys Tyr Pro Cys Asn Arg Val Lys Thr Asp Ser Val Asp Leu 
        595                 600                 605             


Lys Ser Pro Phe Gly Ser Pro Ser Ala Glu Ala Val Ser Ser Arg Leu 
    610                 615                 620                 


Ser Trp Pro Asn His Tyr Ser Gly Ala Ser Glu Ser Gln Thr Arg Ser 
625                 630                 635                 640 


Asp Phe Leu Leu Asp Pro Ser Arg Ser Tyr Ser Tyr Pro Arg Gln Lys 
                645                 650                 655     


Thr Pro Gly Thr Pro Lys Arg Asn Cys Pro Ala Pro Phe Asp Phe Asp 
            660                 665                 670         


Gly Cys Glu Leu Leu Ala Ser Pro Thr Ser Pro Val Thr Ala Glu Phe 
        675                 680                 685             


Ser Ser Ser Val Ser Gly Cys Pro Lys Ser Ala Ser Tyr Ser Leu Glu 
    690                 695                 700                 


Ser Thr Asp Val Lys Ser Leu Ala Ala Gly Val Thr Lys Gln Ser Thr 
705                 710                 715                 720 


Ser Cys Pro Ala Leu Pro Pro Arg Ala Pro Lys Leu Val Glu Glu Lys 
                725                 730                 735     


Val Ala Ser Glu Thr Ser Pro Leu Pro Leu Lys Ile Asp Gly Ala Glu 
            740                 745                 750         


Glu Asp Pro Lys Ser Gly Ser Pro Asp Leu Ser Glu Asp Gln Tyr Phe 
        755                 760                 765             


Val Lys Lys Gly Met Gln Asp Ile Phe Ser Ala Ser Tyr Pro Phe Ser 
    770                 775                 780                 


Ser Pro Leu His Leu Gln Leu Ala Pro Arg Ser Cys Gly Asp Gly Ser 
785                 790                 795                 800 


Pro Trp Gln Pro Pro Ala Asp Leu Ser Gly Leu Ser Ile Glu Glu Val 
                805                 810                 815     


Ser Lys Ser Leu Arg Phe Ile Gly Leu Ser Glu Asp Val Ile Ser Phe 
            820                 825                 830         


Phe Val Thr Glu Lys Ile Asp Gly Asn Leu Leu Val Gln Leu Thr Glu 
        835                 840                 845             


Glu Ile Leu Ser Glu Asp Phe Lys Leu Ser Lys Leu Gln Val Lys Lys 
    850                 855                 860                 


Ile Met Gln Phe Ile Asn Gly Trp Arg Pro Lys Ile 
865                 870                 875     


<210>  4340
<211>  991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GARNL3__Homo_sapiens__NP_001273708

<400>  4340

Met Lys Ser Ser Val Ser Glu Asp Leu Gly Cys Arg Arg Gly Asp Phe 
1               5                   10                  15      


Ser Arg Lys His Tyr Gly Ser Val Glu Leu Leu Ile Ser Ser Asp Ala 
            20                  25                  30          


Asp Gly Ala Ile Gln Arg Ala Gly Arg Phe Arg Val Glu Asn Gly Ser 
        35                  40                  45              


Ser Asp Glu Asn Ala Thr Ala Leu Pro Gly Thr Trp Arg Arg Thr Asp 
    50                  55                  60                  


Val His Leu Glu Asn Pro Glu Tyr His Thr Arg Trp Tyr Phe Lys Tyr 
65                  70                  75                  80  


Phe Leu Gly Gln Val His Gln Asn Tyr Ile Gly Asn Asp Ala Glu Lys 
                85                  90                  95      


Ser Pro Phe Phe Leu Ser Val Thr Leu Ser Asp Gln Asn Asn Gln Arg 
            100                 105                 110         


Val Pro Gln Tyr Arg Ala Ile Leu Trp Arg Lys Thr Gly Thr Gln Lys 
        115                 120                 125             


Ile Cys Leu Pro Tyr Ser Pro Thr Lys Thr Leu Ser Val Lys Ser Ile 
    130                 135                 140                 


Leu Ser Ala Met Asn Leu Asp Lys Phe Glu Lys Gly Pro Arg Glu Ile 
145                 150                 155                 160 


Phe His Pro Glu Ile Gln Lys Asp Leu Leu Val Leu Glu Glu Gln Glu 
                165                 170                 175     


Gly Ser Val Asn Phe Lys Phe Gly Val Leu Phe Ala Lys Asp Gly Gln 
            180                 185                 190         


Leu Thr Asp Asp Glu Met Phe Ser Asn Glu Ile Gly Ser Glu Pro Phe 
        195                 200                 205             


Gln Lys Phe Leu Asn Leu Leu Gly Asp Thr Ile Thr Leu Lys Gly Trp 
    210                 215                 220                 


Thr Gly Tyr Arg Gly Gly Leu Asp Thr Lys Asn Asp Thr Thr Gly Ile 
225                 230                 235                 240 


His Ser Val Tyr Thr Val Tyr Gln Gly His Glu Ile Met Phe His Val 
                245                 250                 255     


Ser Thr Met Leu Pro Tyr Ser Lys Glu Asn Lys Gln Gln Val Glu Arg 
            260                 265                 270         


Lys Arg His Ile Gly Asn Asp Ile Val Thr Ile Val Phe Gln Glu Gly 
        275                 280                 285             


Glu Glu Ser Ser Pro Ala Phe Lys Pro Ser Met Ile Arg Ser His Phe 
    290                 295                 300                 


Thr His Ile Phe Ala Leu Val Arg Tyr Asn Gln Gln Asn Asp Asn Tyr 
305                 310                 315                 320 


Arg Leu Lys Ile Phe Ser Glu Glu Ser Val Pro Leu Phe Gly Pro Pro 
                325                 330                 335     


Leu Pro Thr Pro Pro Val Phe Thr Asp His Gln Glu Phe Arg Asp Phe 
            340                 345                 350         


Leu Leu Val Lys Leu Ile Asn Gly Glu Lys Ala Thr Leu Glu Thr Pro 
        355                 360                 365             


Thr Phe Ala Gln Lys Arg Arg Arg Thr Leu Asp Met Leu Ile Arg Ser 
    370                 375                 380                 


Leu His Gln Asp Leu Met Pro Asp Leu His Lys Asn Met Leu Asn Arg 
385                 390                 395                 400 


Arg Ser Phe Ser Asp Val Leu Pro Glu Ser Pro Lys Ser Ala Arg Lys 
                405                 410                 415     


Lys Glu Glu Ala Arg Gln Ala Glu Phe Val Arg Ile Gly Gln Ala Leu 
            420                 425                 430         


Lys Leu Lys Ser Ile Val Arg Gly Asp Ala Pro Ser Ser Leu Ala Ala 
        435                 440                 445             


Ser Gly Ile Cys Lys Lys Glu Pro Trp Glu Pro Gln Cys Phe Cys Ser 
    450                 455                 460                 


Asn Phe Pro His Glu Ala Val Cys Ala Asp Pro Trp Gly Gln Ala Leu 
465                 470                 475                 480 


Leu Val Ser Thr Asp Ala Gly Val Leu Leu Val Asp Asp Asp Leu Pro 
                485                 490                 495     


Ser Val Pro Val Phe Asp Arg Thr Leu Pro Val Lys Gln Met His Val 
            500                 505                 510         


Leu Glu Thr Leu Asp Leu Leu Val Leu Arg Ala Asp Lys Gly Lys Asp 
        515                 520                 525             


Ala Arg Leu Phe Val Phe Arg Leu Ser Ala Leu Gln Lys Gly Leu Glu 
    530                 535                 540                 


Gly Lys Gln Ala Gly Lys Ser Arg Ser Asp Cys Arg Glu Asn Lys Leu 
545                 550                 555                 560 


Glu Lys Thr Lys Gly Cys His Leu Tyr Ala Ile Asn Thr His His Ser 
                565                 570                 575     


Arg Glu Leu Arg Ile Val Val Ala Ile Arg Asn Lys Leu Leu Leu Ile 
            580                 585                 590         


Thr Arg Lys His Asn Lys Pro Ser Gly Val Thr Ser Thr Ser Leu Leu 
        595                 600                 605             


Ser Pro Leu Ser Glu Ser Pro Val Glu Glu Phe Gln Tyr Ile Arg Glu 
    610                 615                 620                 


Ile Cys Leu Ser Asp Ser Pro Met Val Met Thr Leu Val Asp Gly Pro 
625                 630                 635                 640 


Ala Glu Glu Ser Asp Asn Leu Ile Cys Val Ala Tyr Arg His Gln Phe 
                645                 650                 655     


Asp Val Val Asn Glu Ser Thr Gly Glu Ala Phe Arg Leu His His Val 
            660                 665                 670         


Glu Ala Asn Arg Val Asn Phe Val Ala Ala Ile Asp Val Tyr Glu Asp 
        675                 680                 685             


Gly Glu Ala Gly Leu Leu Leu Cys Tyr Asn Tyr Ser Cys Ile Tyr Lys 
    690                 695                 700                 


Lys Val Cys Pro Phe Asn Gly Gly Ser Phe Leu Val Gln Pro Ser Ala 
705                 710                 715                 720 


Ser Asp Phe Gln Phe Cys Trp Asn Gln Ala Pro Tyr Ala Ile Val Cys 
                725                 730                 735     


Ala Phe Pro Tyr Leu Leu Ala Phe Thr Thr Asp Ser Met Glu Ile Arg 
            740                 745                 750         


Leu Val Val Asn Gly Asn Leu Val His Thr Ala Val Val Pro Gln Leu 
        755                 760                 765             


Gln Leu Val Ala Ser Arg Ser Asp Ile Tyr Phe Thr Ala Thr Ala Ala 
    770                 775                 780                 


Val Asn Glu Val Ser Ser Gly Gly Ser Ser Lys Gly Ala Ser Ala Arg 
785                 790                 795                 800 


Asn Ser Pro Gln Thr Pro Pro Gly Arg Asp Thr Pro Val Phe Pro Ser 
                805                 810                 815     


Ser Leu Gly Glu Gly Glu Ile Gln Ser Lys Asn Leu Tyr Lys Ile Pro 
            820                 825                 830         


Leu Arg Asn Leu Val Gly Arg Ser Ile Glu Arg Pro Leu Lys Ser Pro 
        835                 840                 845             


Leu Val Ser Lys Val Ile Thr Pro Pro Thr Pro Ile Ser Val Gly Leu 
    850                 855                 860                 


Ala Ala Ile Pro Val Thr His Ser Leu Ser Leu Ser Arg Met Glu Ile 
865                 870                 875                 880 


Lys Glu Ile Ala Ser Arg Thr Arg Arg Glu Leu Leu Gly Leu Ser Asp 
                885                 890                 895     


Glu Gly Gly Pro Lys Ser Glu Gly Ala Pro Lys Ala Lys Ser Lys Pro 
            900                 905                 910         


Arg Lys Arg Leu Glu Glu Ser Gln Gly Gly Pro Lys Pro Gly Ala Val 
        915                 920                 925             


Arg Ser Ser Ser Ser Asp Arg Ile Pro Ser Gly Ser Leu Glu Ser Ala 
    930                 935                 940                 


Ser Thr Ser Glu Ala Asn Pro Glu Gly His Ser Ala Ser Ser Asp Gln 
945                 950                 955                 960 


Asp Pro Val Ala Asp Arg Glu Gly Ser Pro Val Ser Gly Ser Ser Pro 
                965                 970                 975     


Phe Gln Leu Thr Ala Phe Ser Asp Glu Asp Ile Ile Asp Leu Lys 
            980                 985                 990     


<210>  4341
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GARS__Homo_sapiens__NP_002038

<400>  4341

Met Pro Ser Pro Arg Pro Val Leu Leu Arg Gly Ala Arg Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Arg Leu Leu Ala Arg Pro Ser Leu Leu Leu 
            20                  25                  30          


Arg Arg Ser Leu Ser Ala Ala Ser Cys Pro Pro Ile Ser Leu Pro Ala 
        35                  40                  45              


Ala Ala Ser Arg Ser Ser Met Asp Gly Ala Gly Ala Glu Glu Val Leu 
    50                  55                  60                  


Ala Pro Leu Arg Leu Ala Val Arg Gln Gln Gly Asp Leu Val Arg Lys 
65                  70                  75                  80  


Leu Lys Glu Asp Lys Ala Pro Gln Val Asp Val Asp Lys Ala Val Ala 
                85                  90                  95      


Glu Leu Lys Ala Arg Lys Arg Val Leu Glu Ala Lys Glu Leu Ala Leu 
            100                 105                 110         


Gln Pro Lys Asp Asp Ile Val Asp Arg Ala Lys Met Glu Asp Thr Leu 
        115                 120                 125             


Lys Arg Arg Phe Phe Tyr Asp Gln Ala Phe Ala Ile Tyr Gly Gly Val 
    130                 135                 140                 


Ser Gly Leu Tyr Asp Phe Gly Pro Val Gly Cys Ala Leu Lys Asn Asn 
145                 150                 155                 160 


Ile Ile Gln Thr Trp Arg Gln His Phe Ile Gln Glu Glu Gln Ile Leu 
                165                 170                 175     


Glu Ile Asp Cys Thr Met Leu Thr Pro Glu Pro Val Leu Lys Thr Ser 
            180                 185                 190         


Gly His Val Asp Lys Phe Ala Asp Phe Met Val Lys Asp Val Lys Asn 
        195                 200                 205             


Gly Glu Cys Phe Arg Ala Asp His Leu Leu Lys Ala His Leu Gln Lys 
    210                 215                 220                 


Leu Met Ser Asp Lys Lys Cys Ser Val Glu Lys Lys Ser Glu Met Glu 
225                 230                 235                 240 


Ser Val Leu Ala Gln Leu Asp Asn Tyr Gly Gln Gln Glu Leu Ala Asp 
                245                 250                 255     


Leu Phe Val Asn Tyr Asn Val Lys Ser Pro Ile Thr Gly Asn Asp Leu 
            260                 265                 270         


Ser Pro Pro Val Ser Phe Asn Leu Met Phe Lys Thr Phe Ile Gly Pro 
        275                 280                 285             


Gly Gly Asn Met Pro Gly Tyr Leu Arg Pro Glu Thr Ala Gln Gly Ile 
    290                 295                 300                 


Phe Leu Asn Phe Lys Arg Leu Leu Glu Phe Asn Gln Gly Lys Leu Pro 
305                 310                 315                 320 


Phe Ala Ala Ala Gln Ile Gly Asn Ser Phe Arg Asn Glu Ile Ser Pro 
                325                 330                 335     


Arg Ser Gly Leu Ile Arg Val Arg Glu Phe Thr Met Ala Glu Ile Glu 
            340                 345                 350         


His Phe Val Asp Pro Ser Glu Lys Asp His Pro Lys Phe Gln Asn Val 
        355                 360                 365             


Ala Asp Leu His Leu Tyr Leu Tyr Ser Ala Lys Ala Gln Val Ser Gly 
    370                 375                 380                 


Gln Ser Ala Arg Lys Met Arg Leu Gly Asp Ala Val Glu Gln Gly Val 
385                 390                 395                 400 


Ile Asn Asn Thr Val Leu Gly Tyr Phe Ile Gly Arg Ile Tyr Leu Tyr 
                405                 410                 415     


Leu Thr Lys Val Gly Ile Ser Pro Asp Lys Leu Arg Phe Arg Gln His 
            420                 425                 430         


Met Glu Asn Glu Met Ala His Tyr Ala Cys Asp Cys Trp Asp Ala Glu 
        435                 440                 445             


Ser Lys Thr Ser Tyr Gly Trp Ile Glu Ile Val Gly Cys Ala Asp Arg 
    450                 455                 460                 


Ser Cys Tyr Asp Leu Ser Cys His Ala Arg Ala Thr Lys Val Pro Leu 
465                 470                 475                 480 


Val Ala Glu Lys Pro Leu Lys Glu Pro Lys Thr Val Asn Val Val Gln 
                485                 490                 495     


Phe Glu Pro Ser Lys Gly Ala Ile Gly Lys Ala Tyr Lys Lys Asp Ala 
            500                 505                 510         


Lys Leu Val Met Glu Tyr Leu Ala Ile Cys Asp Glu Cys Tyr Ile Thr 
        515                 520                 525             


Glu Met Glu Met Leu Leu Asn Glu Lys Gly Glu Phe Thr Ile Glu Thr 
    530                 535                 540                 


Glu Gly Lys Thr Phe Gln Leu Thr Lys Asp Met Ile Asn Val Lys Arg 
545                 550                 555                 560 


Phe Gln Lys Thr Leu Tyr Val Glu Glu Val Val Pro Asn Val Ile Glu 
                565                 570                 575     


Pro Ser Phe Gly Leu Gly Arg Ile Met Tyr Thr Val Phe Glu His Thr 
            580                 585                 590         


Phe His Val Arg Glu Gly Asp Glu Gln Arg Thr Phe Phe Ser Phe Pro 
        595                 600                 605             


Ala Val Val Ala Pro Phe Lys Cys Ser Val Leu Pro Leu Ser Gln Asn 
    610                 615                 620                 


Gln Glu Phe Met Pro Phe Val Lys Glu Leu Ser Glu Ala Leu Thr Arg 
625                 630                 635                 640 


His Gly Val Ser His Lys Val Asp Asp Ser Ser Gly Ser Ile Gly Arg 
                645                 650                 655     


Arg Tyr Ala Arg Thr Asp Glu Ile Gly Val Ala Phe Gly Val Thr Ile 
            660                 665                 670         


Asp Phe Asp Thr Val Asn Lys Thr Pro His Thr Ala Thr Leu Arg Asp 
        675                 680                 685             


Arg Asp Ser Met Arg Gln Ile Arg Ala Glu Ile Ser Glu Leu Pro Ser 
    690                 695                 700                 


Ile Val Gln Asp Leu Ala Asn Gly Asn Ile Thr Trp Ala Asp Val Glu 
705                 710                 715                 720 


Ala Arg Tyr Pro Leu Phe Glu Gly Gln Glu Thr Gly Lys Lys Glu Thr 
                725                 730                 735     


Ile Glu Glu 
            


<210>  4342
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GART__Homo_sapiens__NP_780294

<400>  4342

Met Ala Ala Arg Val Leu Ile Ile Gly Ser Gly Gly Arg Glu His Thr 
1               5                   10                  15      


Leu Ala Trp Lys Leu Ala Gln Ser His His Val Lys Gln Val Leu Val 
            20                  25                  30          


Ala Pro Gly Asn Ala Gly Thr Ala Cys Ser Glu Lys Ile Ser Asn Thr 
        35                  40                  45              


Ala Ile Ser Ile Ser Asp His Thr Ala Leu Ala Gln Phe Cys Lys Glu 
    50                  55                  60                  


Lys Lys Ile Glu Phe Val Val Val Gly Pro Glu Ala Pro Leu Ala Ala 
65                  70                  75                  80  


Gly Ile Val Gly Asn Leu Arg Ser Ala Gly Val Gln Cys Phe Gly Pro 
                85                  90                  95      


Thr Ala Glu Ala Ala Gln Leu Glu Ser Ser Lys Arg Phe Ala Lys Glu 
            100                 105                 110         


Phe Met Asp Arg His Gly Ile Pro Thr Ala Gln Trp Lys Ala Phe Thr 
        115                 120                 125             


Lys Pro Glu Glu Ala Cys Ser Phe Ile Leu Ser Ala Asp Phe Pro Ala 
    130                 135                 140                 


Leu Val Val Lys Ala Ser Gly Leu Ala Ala Gly Lys Gly Val Ile Val 
145                 150                 155                 160 


Ala Lys Ser Lys Glu Glu Ala Cys Lys Ala Val Gln Glu Ile Met Gln 
                165                 170                 175     


Glu Lys Ala Phe Gly Ala Ala Gly Glu Thr Ile Val Ile Glu Glu Leu 
            180                 185                 190         


Leu Asp Gly Glu Glu Val Ser Cys Leu Cys Phe Thr Asp Gly Lys Thr 
        195                 200                 205             


Val Ala Pro Met Pro Pro Ala Gln Asp His Lys Arg Leu Leu Glu Gly 
    210                 215                 220                 


Asp Gly Gly Pro Asn Thr Gly Gly Met Gly Ala Tyr Cys Pro Ala Pro 
225                 230                 235                 240 


Gln Val Ser Asn Asp Leu Leu Leu Lys Ile Lys Asp Thr Val Leu Gln 
                245                 250                 255     


Arg Thr Val Asp Gly Met Gln Gln Glu Gly Thr Pro Tyr Thr Gly Ile 
            260                 265                 270         


Leu Tyr Ala Gly Ile Met Leu Thr Lys Asn Gly Pro Lys Val Leu Glu 
        275                 280                 285             


Phe Asn Cys Arg Phe Gly Asp Pro Glu Cys Gln Val Ile Leu Pro Leu 
    290                 295                 300                 


Leu Lys Ser Asp Leu Tyr Glu Val Ile Gln Ser Thr Leu Asp Gly Leu 
305                 310                 315                 320 


Leu Cys Thr Ser Leu Pro Val Trp Leu Glu Asn His Thr Ala Leu Thr 
                325                 330                 335     


Val Val Met Ala Ser Lys Gly Tyr Pro Gly Asp Tyr Thr Lys Gly Val 
            340                 345                 350         


Glu Ile Thr Gly Phe Pro Glu Ala Gln Ala Leu Gly Leu Glu Val Phe 
        355                 360                 365             


His Ala Gly Thr Ala Leu Lys Asn Gly Lys Val Val Thr His Gly Gly 
    370                 375                 380                 


Arg Val Leu Ala Val Thr Ala Ile Arg Glu Asn Leu Ile Ser Ala Leu 
385                 390                 395                 400 


Glu Glu Ala Lys Lys Gly Leu Ala Ala Ile Lys Phe Glu Gly Ala Ile 
                405                 410                 415     


Tyr Arg Lys Asp Val Gly Phe Arg Ala Ile Ala Phe Leu Gln Gln Pro 
            420                 425                 430         


Arg 
    


<210>  4343
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAS1__Homo_sapiens__NP_002039

<400>  4343

Met Val Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr 
1               5                   10                  15      


Val Pro Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly 
            20                  25                  30          


Ser Ala Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys 
        35                  40                  45              


Trp Gln Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala 
    50                  55                  60                  


Tyr Asn Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala 
                85                  90                  95      


Ala Ser Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala 
            100                 105                 110         


Leu Ile Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys 
        115                 120                 125             


Asp Cys Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu 
    130                 135                 140                 


Pro Cys Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala 
145                 150                 155                 160 


Gly Gly Val Met Gly Cys Thr Glu Ala Arg Arg Arg Cys Asp Arg Asp 
                165                 170                 175     


Ser Arg Cys Asn Leu Ala Leu Ser Arg Tyr Leu Thr Tyr Cys Gly Lys 
            180                 185                 190         


Val Phe Asn Gly Leu Arg Cys Thr Asp Glu Cys Arg Thr Val Ile Glu 
        195                 200                 205             


Asp Met Leu Ala Met Pro Lys Ala Ala Leu Leu Asn Asp Cys Val Cys 
    210                 215                 220                 


Asp Gly Leu Glu Arg Pro Ile Cys Glu Ser Val Lys Glu Asn Met Ala 
225                 230                 235                 240 


Arg Leu Cys Phe Gly Ala Glu Leu Gly Asn Gly Pro Gly Ser Ser Gly 
                245                 250                 255     


Ser Asp Gly Gly Leu Asp Asp Tyr Tyr Asp Glu Asp Tyr Asp Asp Glu 
            260                 265                 270         


Gln Arg Thr Gly Gly Ala Gly Gly Glu Gln Pro Leu Asp Asp Asp Asp 
        275                 280                 285             


Gly Val Pro His Pro Pro Arg Pro Gly Ser Gly Ala Ala Ala Ser Gly 
    290                 295                 300                 


Gly Arg Gly Asp Leu Pro Tyr Gly Pro Gly Arg Arg Ser Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Arg Leu Ala Pro Arg Gly Ala Trp Thr Pro Leu Ala Ser Ile 
                325                 330                 335     


Leu Leu Leu Leu Leu Gly Pro Leu Phe 
            340                 345 


<210>  4344
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAS2__Homo_sapiens__NP_001137302

<400>  4344

Met Cys Thr Ala Leu Ser Pro Lys Val Arg Ser Gly Pro Gly Leu Ser 
1               5                   10                  15      


Asp Met His Gln Tyr Ser Gln Trp Leu Ala Ser Arg His Glu Ala Asn 
            20                  25                  30          


Leu Leu Pro Met Lys Glu Asp Leu Ala Leu Trp Leu Thr Asn Leu Leu 
        35                  40                  45              


Gly Lys Glu Ile Thr Ala Glu Thr Phe Met Glu Lys Leu Asp Asn Gly 
    50                  55                  60                  


Ala Leu Leu Cys Gln Leu Ala Glu Thr Met Gln Glu Lys Phe Lys Glu 
65                  70                  75                  80  


Ser Met Asp Ala Asn Lys Pro Thr Lys Asn Leu Pro Leu Lys Lys Ile 
                85                  90                  95      


Pro Cys Lys Thr Ser Ala Pro Ser Gly Ser Phe Phe Ala Arg Asp Asn 
            100                 105                 110         


Thr Ala Asn Phe Leu Ser Trp Cys Arg Asp Leu Gly Val Asp Glu Thr 
        115                 120                 125             


Cys Leu Phe Glu Ser Glu Gly Leu Val Leu His Lys Gln Pro Arg Glu 
    130                 135                 140                 


Val Cys Leu Cys Leu Leu Glu Leu Gly Arg Ile Ala Ala Arg Tyr Gly 
145                 150                 155                 160 


Val Glu Pro Pro Gly Leu Ile Lys Leu Glu Lys Glu Ile Glu Gln Glu 
                165                 170                 175     


Glu Thr Leu Ser Ala Pro Ser Pro Ser Pro Ser Pro Ser Ser Lys Ser 
            180                 185                 190         


Ser Gly Lys Lys Ser Thr Gly Asn Leu Leu Asp Asp Ala Val Lys Arg 
        195                 200                 205             


Ile Ser Glu Asp Pro Pro Cys Lys Cys Pro Asn Lys Phe Cys Val Glu 
    210                 215                 220                 


Arg Leu Ser Gln Gly Arg Tyr Arg Val Gly Glu Lys Ile Leu Phe Ile 
225                 230                 235                 240 


Arg Met Leu His Asn Lys His Val Met Val Arg Val Gly Gly Gly Trp 
                245                 250                 255     


Glu Thr Phe Ala Gly Tyr Leu Leu Lys His Asp Pro Cys Arg Met Leu 
            260                 265                 270         


Gln Ile Ser Arg Val Asp Gly Lys Thr Ser Pro Ile Gln Ser Lys Ser 
        275                 280                 285             


Pro Thr Leu Lys Asp Met Asn Pro Asp Asn Tyr Leu Val Val Ser Ala 
    290                 295                 300                 


Ser Tyr Lys Ala Lys Lys Glu Ile Lys 
305                 310             


<210>  4345
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAS2L1__Homo_sapiens__NP_001265659

<400>  4345

Met Ala Asp Pro Val Ala Gly Ile Ala Gly Ser Ala Ala Lys Ser Val 
1               5                   10                  15      


Arg Pro Phe Arg Ser Ser Glu Ala Tyr Val Glu Ala Met Lys Glu Asp 
            20                  25                  30          


Leu Ala Glu Trp Leu Asn Ala Leu Tyr Gly Leu Gly Leu Pro Gly Gly 
        35                  40                  45              


Gly Asp Gly Phe Leu Thr Gly Leu Ala Thr Gly Thr Thr Leu Cys Gln 
    50                  55                  60                  


His Ala Asn Ala Val Thr Glu Ala Ala Arg Ala Leu Ala Ala Ala Arg 
65                  70                  75                  80  


Pro Ala Arg Gly Val Ala Phe Gln Ala His Ser Val Val Pro Gly Ser 
                85                  90                  95      


Phe Met Ala Arg Asp Asn Val Ala Thr Phe Ile Gly Trp Cys Arg Val 
            100                 105                 110         


Glu Leu Gly Val Pro Glu Val Leu Met Phe Glu Thr Glu Asp Leu Val 
        115                 120                 125             


Leu Arg Lys Asn Glu Lys Ser Val Val Leu Cys Leu Leu Glu Val Ala 
    130                 135                 140                 


Arg Arg Gly Ala Arg Leu Gly Leu Leu Ala Pro Arg Leu Val Gln Phe 
145                 150                 155                 160 


Glu Gln Glu Ile Glu Arg Glu Leu Arg Ala Ala Pro Pro Ala Pro Asn 
                165                 170                 175     


Ala Pro Ala Ala Gly Glu Asp Thr Thr Glu Thr Ala Pro Ala Pro Gly 
            180                 185                 190         


Thr Pro Ala Arg Gly Pro Arg Met Thr Pro Ser Asp Leu Arg Asn Leu 
        195                 200                 205             


Asp Glu Leu Val Arg Glu Ile Leu Gly Arg Cys Thr Cys Pro Asp Gln 
    210                 215                 220                 


Phe Pro Met Ile Lys Val Ser Glu Gly Lys Tyr Arg Val Gly Asp Ser 
225                 230                 235                 240 


Ser Leu Leu Ile Phe Val Arg Val Leu Arg Ser His Val Met Val Arg 
                245                 250                 255     


Val Gly Gly Gly Trp Asp Thr Leu Glu His Tyr Leu Asp Lys His Asp 
            260                 265                 270         


Pro Cys Arg Cys Ser Ser Thr Ala His Arg Pro Pro Gln Pro Arg Val 
        275                 280                 285             


Cys Thr Phe Ser Pro Gln Arg Val Ser Pro Thr Thr Ser Pro Arg Pro 
    290                 295                 300                 


Ala Ser Pro Val Pro Gly Ser Glu Arg Arg Gly Ser Arg Pro Glu Met 
305                 310                 315                 320 


Thr Pro Val Ser Leu Arg Ser Thr Lys Glu Gly Pro Glu Thr Pro Pro 
                325                 330                 335     


Ser Ser Ser Ser Ser Ser Leu Ser Val Leu Gly Gly Lys Cys Gly Gln 
            340                 345                 350         


Pro Gly Asp Ser Gly Arg Thr Ala Asn Gly Leu Pro Gly Pro Arg Ser 
        355                 360                 365             


Gln Ala Leu Ser Ser Ser Ser Asp Glu Gly Ser Pro Cys Pro Gly Met 
    370                 375                 380                 


Gly Gly Pro Leu Asp Ala Pro Gly Ser Pro Leu Ala Cys Thr Glu Pro 
385                 390                 395                 400 


Ser Arg Thr Trp Ala Arg Gly Arg Met Asp Thr Gln Pro Asp Arg Lys 
                405                 410                 415     


Pro Ser Arg Ile Pro Thr Pro Arg Gly Pro Arg Arg Pro Ser Gly Pro 
            420                 425                 430         


Ala Glu Leu Gly Thr Trp His Ala Leu His Ser Val Thr Pro Arg Ala 
        435                 440                 445             


Glu Pro Asp Ser Trp Met 
    450                 


<210>  4346
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAS6__Homo_sapiens__NP_000811

<400>  4346

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 
                85                  90                  95      


Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 
            100                 105                 110         


Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 
        115                 120                 125             


Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 
    130                 135                 140                 


Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 
145                 150                 155                 160 


Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 
                165                 170                 175     


Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 
        195                 200                 205             


Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 
    210                 215                 220                 


Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 
225                 230                 235                 240 


Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 
                245                 250                 255     


Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 
            260                 265                 270         


Asp Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val 
        275                 280                 285             


Ala Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr 
    290                 295                 300                 


Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val 
305                 310                 315                 320 


Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe 
                325                 330                 335     


Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala 
            340                 345                 350         


Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr 
        355                 360                 365             


Ser Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val 
    370                 375                 380                 


Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val 
385                 390                 395                 400 


Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu 
                405                 410                 415     


Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp 
            420                 425                 430         


Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp 
        435                 440                 445             


Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val 
    450                 455                 460                 


Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr 
465                 470                 475                 480 


Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro 
                485                 490                 495     


Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His 
            500                 505                 510         


Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro 
        515                 520                 525             


Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser 
    530                 535                 540                 


Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr 
545                 550                 555                 560 


Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val 
                565                 570                 575     


Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly 
            580                 585                 590         


Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu 
        595                 600                 605             


Ala Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly 
    610                 615                 620                 


Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr 
625                 630                 635                 640 


Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp 
                645                 650                 655     


Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro 
            660                 665                 670         


Val Glu Pro Ala Ala Ala 
        675             


<210>  4347
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAS7__Homo_sapiens__NP_001124303

<400>  4347

Met Val Pro Pro Pro Pro Gly Glu Glu Ser Gln Thr Val Ile Leu Pro 
1               5                   10                  15      


Pro Gly Trp Gln Ser Tyr Leu Ser Pro Gln Gly Arg Arg Tyr Tyr Val 
            20                  25                  30          


Asn Thr Thr Thr Asn Glu Thr Thr Trp Glu Arg Pro Ser Ser Ser Pro 
        35                  40                  45              


Gly Ile Pro Ala Ser Pro Gly Ser His Arg Ser Ser Leu Pro Pro Thr 
    50                  55                  60                  


Val Asn Gly Tyr His Ala Ser Gly Thr Pro Ala His Pro Pro Glu Thr 
65                  70                  75                  80  


Ala His Met Ser Val Arg Lys Ser Thr Gly Asp Ser Gln Asn Leu Gly 
                85                  90                  95      


Ser Ser Ser Pro Ser Lys Lys Gln Ser Lys Glu Asn Thr Ile Thr Ile 
            100                 105                 110         


Asn Cys Val Thr Phe Pro His Pro Asp Thr Met Pro Glu Gln Gln Leu 
        115                 120                 125             


Leu Lys Pro Thr Glu Trp Ser Tyr Cys Asp Tyr Phe Trp Ala Asp Lys 
    130                 135                 140                 


Lys Asp Pro Gln Gly Asn Gly Thr Val Ala Gly Phe Glu Leu Leu Leu 
145                 150                 155                 160 


Gln Lys Gln Leu Lys Gly Lys Gln Met Gln Lys Glu Met Ser Glu Phe 
                165                 170                 175     


Ile Arg Glu Arg Ile Lys Ile Glu Glu Asp Tyr Ala Lys Asn Leu Ala 
            180                 185                 190         


Lys Leu Ser Gln Asn Ser Leu Ala Ser Gln Glu Glu Gly Ser Leu Gly 
        195                 200                 205             


Glu Ala Trp Ala Gln Val Lys Lys Ser Leu Ala Asp Glu Ala Glu Val 
    210                 215                 220                 


His Leu Lys Phe Ser Ala Lys Leu His Ser Glu Val Glu Lys Pro Leu 
225                 230                 235                 240 


Met Asn Phe Arg Glu Asn Phe Lys Lys Asp Met Lys Lys Cys Asp His 
                245                 250                 255     


His Ile Ala Asp Leu Arg Lys Gln Leu Ala Ser Arg Tyr Ala Ser Val 
            260                 265                 270         


Glu Lys Ala Arg Lys Ala Leu Thr Glu Arg Gln Arg Asp Leu Glu Met 
        275                 280                 285             


Lys Thr Gln Gln Leu Glu Ile Lys Leu Ser Asn Lys Thr Glu Glu Asp 
    290                 295                 300                 


Ile Lys Lys Ala Arg Arg Lys Ser Thr Gln Ala Gly Asp Asp Leu Met 
305                 310                 315                 320 


Arg Cys Val Asp Leu Tyr Asn Gln Ala Gln Ser Lys Trp Phe Glu Glu 
                325                 330                 335     


Met Val Thr Thr Thr Leu Glu Leu Glu Arg Leu Glu Val Glu Arg Val 
            340                 345                 350         


Glu Met Ile Arg Gln His Leu Cys Gln Tyr Thr Gln Leu Arg His Glu 
        355                 360                 365             


Thr Asp Met Phe Asn Gln Ser Thr Val Glu Pro Val Asp Gln Leu Leu 
    370                 375                 380                 


Arg Lys Val Asp Pro Ala Lys Asp Arg Glu Leu Trp Val Arg Glu His 
385                 390                 395                 400 


Lys Thr Gly Asn Ile Arg Pro Val Asp Met Glu Ile 
                405                 410         


<210>  4348
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAS8__Homo_sapiens__NP_001273137

<400>  4348

Met Lys Met Leu Arg Asp Glu Leu Asp Leu Arg Arg Lys Thr Glu Leu 
1               5                   10                  15      


His Glu Val Glu Glu Arg Lys Asn Gly Gln Ile His Thr Leu Met Gln 
            20                  25                  30          


Arg His Glu Glu Ala Phe Thr Asp Ile Lys Asn Tyr Tyr Asn Asp Ile 
        35                  40                  45              


Thr Leu Asn Asn Leu Ala Leu Ile Asn Ser Leu Lys Glu Gln Met Glu 
    50                  55                  60                  


Asp Met Arg Lys Lys Glu Asp His Leu Glu Arg Glu Met Ala Glu Val 
65                  70                  75                  80  


Ser Gly Gln Asn Lys Arg Leu Ala Asp Pro Leu Gln Lys Ala Arg Glu 
                85                  90                  95      


Glu Met Ser Glu Met Gln Lys Gln Leu Ala Asn Tyr Glu Arg Asp Lys 
            100                 105                 110         


Gln Ile Leu Leu Cys Thr Lys Ala Arg Leu Lys Val Arg Glu Lys Glu 
        115                 120                 125             


Leu Lys Asp Leu Gln Trp Glu His Glu Val Leu Glu Gln Arg Phe Thr 
    130                 135                 140                 


Lys Val Gln Gln Glu Arg Asp Glu Leu Tyr Arg Lys Phe Thr Ala Ala 
145                 150                 155                 160 


Ile Gln Glu Val Gln Gln Lys Thr Gly Phe Lys Asn Leu Val Leu Glu 
                165                 170                 175     


Arg Lys Leu Gln Ala Leu Ser Ala Ala Val Glu Lys Lys Glu Val Gln 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Ala Ser Asn Leu Asp Pro Ala Ala Leu Thr 
        195                 200                 205             


Leu Val Ser Arg Lys Leu Glu Asp Val Leu Glu Ser Lys Asn Ser Thr 
    210                 215                 220                 


Ile Lys Asp Leu Gln Tyr Glu Leu Ala Gln Val Cys Lys Ala His Asn 
225                 230                 235                 240 


Asp Leu Leu Arg Thr Tyr Glu Ala Lys Leu Leu Ala Phe Gly Ile Pro 
                245                 250                 255     


Leu Asp Asn Val Gly Phe Lys Pro Leu Glu Thr Ala Val Ile Gly Gln 
            260                 265                 270         


Thr Leu Gly Gln Gly Pro Ala Gly Leu Val Gly Thr Pro Thr 
        275                 280                 285     


<210>  4349
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAST__Homo_sapiens__NP_000796

<400>  4349

Met Gln Arg Leu Cys Val Tyr Val Leu Ile Phe Ala Leu Ala Leu Ala 
1               5                   10                  15      


Ala Phe Ser Glu Ala Ser Trp Lys Pro Arg Ser Gln Gln Pro Asp Ala 
            20                  25                  30          


Pro Leu Gly Thr Gly Ala Asn Arg Asp Leu Glu Leu Pro Trp Leu Glu 
        35                  40                  45              


Gln Gln Gly Pro Ala Ser His His Arg Arg Gln Leu Gly Pro Gln Gly 
    50                  55                  60                  


Pro Pro His Leu Val Ala Asp Pro Ser Lys Lys Gln Gly Pro Trp Leu 
65                  70                  75                  80  


Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp Phe Gly Arg Arg Ser 
                85                  90                  95      


Ala Glu Asp Glu Asn 
            100     


<210>  4350
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATA1__Homo_sapiens__NP_002040

<400>  4350

Met Glu Phe Pro Gly Leu Gly Ser Leu Gly Thr Ser Glu Pro Leu Pro 
1               5                   10                  15      


Gln Phe Val Asp Pro Ala Leu Val Ser Ser Thr Pro Glu Ser Gly Val 
            20                  25                  30          


Phe Phe Pro Ser Gly Pro Glu Gly Leu Asp Ala Ala Ala Ser Ser Thr 
        35                  40                  45              


Ala Pro Ser Thr Ala Thr Ala Ala Ala Ala Ala Leu Ala Tyr Tyr Arg 
    50                  55                  60                  


Asp Ala Glu Ala Tyr Arg His Ser Pro Val Phe Gln Val Tyr Pro Leu 
65                  70                  75                  80  


Leu Asn Cys Met Glu Gly Ile Pro Gly Gly Ser Pro Tyr Ala Gly Trp 
                85                  90                  95      


Ala Tyr Gly Lys Thr Gly Leu Tyr Pro Ala Ser Thr Val Cys Pro Thr 
            100                 105                 110         


Arg Glu Asp Ser Pro Pro Gln Ala Val Glu Asp Leu Asp Gly Lys Gly 
        115                 120                 125             


Ser Thr Ser Phe Leu Glu Thr Leu Lys Thr Glu Arg Leu Ser Pro Asp 
    130                 135                 140                 


Leu Leu Thr Leu Gly Pro Ala Leu Pro Ser Ser Leu Pro Val Pro Asn 
145                 150                 155                 160 


Ser Ala Tyr Gly Gly Pro Asp Phe Ser Ser Thr Phe Phe Ser Pro Thr 
                165                 170                 175     


Gly Ser Pro Leu Asn Ser Ala Ala Tyr Ser Ser Pro Lys Leu Arg Gly 
            180                 185                 190         


Thr Leu Pro Leu Pro Pro Cys Glu Ala Arg Glu Cys Val Asn Cys Gly 
        195                 200                 205             


Ala Thr Ala Thr Pro Leu Trp Arg Arg Asp Arg Thr Gly His Tyr Leu 
    210                 215                 220                 


Cys Asn Ala Cys Gly Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro 
225                 230                 235                 240 


Leu Ile Arg Pro Lys Lys Arg Leu Ile Val Ser Lys Arg Ala Gly Thr 
                245                 250                 255     


Gln Cys Thr Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn 
            260                 265                 270         


Ala Ser Gly Asp Pro Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu 
        275                 280                 285             


His Gln Val Asn Arg Pro Leu Thr Met Arg Lys Asp Gly Ile Gln Thr 
    290                 295                 300                 


Arg Asn Arg Lys Ala Ser Gly Lys Gly Lys Lys Lys Arg Gly Ser Ser 
305                 310                 315                 320 


Leu Gly Gly Thr Gly Ala Ala Glu Gly Pro Ala Gly Gly Phe Met Val 
                325                 330                 335     


Val Ala Gly Gly Ser Gly Ser Gly Asn Cys Gly Glu Val Ala Ser Gly 
            340                 345                 350         


Leu Thr Leu Gly Pro Pro Gly Thr Ala His Leu Tyr Gln Gly Leu Gly 
        355                 360                 365             


Pro Val Val Leu Ser Gly Pro Val Ser His Leu Met Pro Phe Pro Gly 
    370                 375                 380                 


Pro Leu Leu Gly Ser Pro Thr Gly Ser Phe Pro Thr Gly Pro Met Pro 
385                 390                 395                 400 


Pro Thr Thr Ser Thr Thr Val Val Ala Pro Leu Ser Ser 
                405                 410             


<210>  4351
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATA2__Homo_sapiens__NP_001139133

<400>  4351

Met Glu Val Ala Pro Glu Gln Pro Arg Trp Met Ala His Pro Ala Val 
1               5                   10                  15      


Leu Asn Ala Gln His Pro Asp Ser His His Pro Gly Leu Ala His Asn 
            20                  25                  30          


Tyr Met Glu Pro Ala Gln Leu Leu Pro Pro Asp Glu Val Asp Val Phe 
        35                  40                  45              


Phe Asn His Leu Asp Ser Gln Gly Asn Pro Tyr Tyr Ala Asn Pro Ala 
    50                  55                  60                  


His Ala Arg Ala Arg Val Ser Tyr Ser Pro Ala His Ala Arg Leu Thr 
65                  70                  75                  80  


Gly Gly Gln Met Cys Arg Pro His Leu Leu His Ser Pro Gly Leu Pro 
                85                  90                  95      


Trp Leu Asp Gly Gly Lys Ala Ala Leu Ser Ala Ala Ala Ala His His 
            100                 105                 110         


His Asn Pro Trp Thr Val Ser Pro Phe Ser Lys Thr Pro Leu His Pro 
        115                 120                 125             


Ser Ala Ala Gly Gly Pro Gly Gly Pro Leu Ser Val Tyr Pro Gly Ala 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Ser Val Ala Ser Leu Thr 
145                 150                 155                 160 


Pro Thr Ala Ala His Ser Gly Ser His Leu Phe Gly Phe Pro Pro Thr 
                165                 170                 175     


Pro Pro Lys Glu Val Ser Pro Asp Pro Ser Thr Thr Gly Ala Ala Ser 
            180                 185                 190         


Pro Ala Ser Ser Ser Ala Gly Gly Ser Ala Ala Arg Gly Glu Asp Lys 
        195                 200                 205             


Asp Gly Val Lys Tyr Gln Val Ser Leu Thr Glu Ser Met Lys Met Glu 
    210                 215                 220                 


Ser Gly Ser Pro Leu Arg Pro Gly Leu Ala Thr Met Gly Thr Gln Pro 
225                 230                 235                 240 


Ala Thr His His Pro Ile Pro Thr Tyr Pro Ser Tyr Val Pro Ala Ala 
                245                 250                 255     


Ala His Asp Tyr Ser Ser Gly Leu Phe His Pro Gly Gly Phe Leu Gly 
            260                 265                 270         


Gly Pro Ala Ser Ser Phe Thr Pro Lys Gln Arg Ser Lys Ala Arg Ser 
        275                 280                 285             


Cys Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Thr Ala Thr Pro 
    290                 295                 300                 


Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly 
305                 310                 315                 320 


Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro Leu Ile Lys Pro Lys 
                325                 330                 335     


Arg Arg Leu Ser Ala Ala Arg Arg Ala Gly Thr Cys Cys Ala Asn Cys 
            340                 345                 350         


Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Asn Gly Asp Pro 
        355                 360                 365             


Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu His Asn Val Asn Arg 
    370                 375                 380                 


Pro Leu Thr Met Lys Lys Glu Gly Ile Gln Thr Arg Asn Arg Lys Met 
385                 390                 395                 400 


Ser Asn Lys Ser Lys Lys Ser Lys Lys Gly Ala Glu Cys Phe Glu Glu 
                405                 410                 415     


Leu Ser Lys Cys Met Gln Glu Lys Ser Ser Pro Phe Ser Ala Ala Ala 
            420                 425                 430         


Leu Ala Gly His Met Ala Pro Val Gly His Leu Pro Pro Phe Ser His 
        435                 440                 445             


Ser Gly His Ile Leu Pro Thr Pro Thr Pro Ile His Pro Ser Ser Ser 
    450                 455                 460                 


Leu Ser Phe Gly His Pro His Pro Ser Ser Met Val Thr Ala Met Gly 
465                 470                 475                 480 


<210>  4352
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATA3__Homo_sapiens__NP_002042

<400>  4352

Met Glu Val Thr Ala Asp Gln Pro Arg Trp Val Ser His His His Pro 
1               5                   10                  15      


Ala Val Leu Asn Gly Gln His Pro Asp Thr His His Pro Gly Leu Ser 
            20                  25                  30          


His Ser Tyr Met Asp Ala Ala Gln Tyr Pro Leu Pro Glu Glu Val Asp 
        35                  40                  45              


Val Leu Phe Asn Ile Asp Gly Gln Gly Asn His Val Pro Pro Tyr Tyr 
    50                  55                  60                  


Gly Asn Ser Val Arg Ala Thr Val Gln Arg Tyr Pro Pro Thr His His 
65                  70                  75                  80  


Gly Ser Gln Val Cys Arg Pro Pro Leu Leu His Gly Ser Leu Pro Trp 
                85                  90                  95      


Leu Asp Gly Gly Lys Ala Leu Gly Ser His His Thr Ala Ser Pro Trp 
            100                 105                 110         


Asn Leu Ser Pro Phe Ser Lys Thr Ser Ile His His Gly Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Val Tyr Pro Pro Ala Ser Ser Ser Ser Leu Ser Gly Gly 
    130                 135                 140                 


His Ala Ser Pro His Leu Phe Thr Phe Pro Pro Thr Pro Pro Lys Asp 
145                 150                 155                 160 


Val Ser Pro Asp Pro Ser Leu Ser Thr Pro Gly Ser Ala Gly Ser Ala 
                165                 170                 175     


Arg Gln Asp Glu Lys Glu Cys Leu Lys Tyr Gln Val Pro Leu Pro Asp 
            180                 185                 190         


Ser Met Lys Leu Glu Ser Ser His Ser Arg Gly Ser Met Thr Ala Leu 
        195                 200                 205             


Gly Gly Ala Ser Ser Ser Thr His His Pro Ile Thr Thr Tyr Pro Pro 
    210                 215                 220                 


Tyr Val Pro Glu Tyr Ser Ser Gly Leu Phe Pro Pro Ser Ser Leu Leu 
225                 230                 235                 240 


Gly Gly Ser Pro Thr Gly Phe Gly Cys Lys Ser Arg Pro Lys Ala Arg 
                245                 250                 255     


Ser Ser Thr Gly Arg Glu Cys Val Asn Cys Gly Ala Thr Ser Thr Pro 
            260                 265                 270         


Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly 
        275                 280                 285             


Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro Leu Ile Lys Pro Lys 
    290                 295                 300                 


Arg Arg Leu Ser Ala Ala Arg Arg Ala Gly Thr Ser Cys Ala Asn Cys 
305                 310                 315                 320 


Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Asn Gly Asp Pro 
                325                 330                 335     


Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu His Asn Ile Asn Arg 
            340                 345                 350         


Pro Leu Thr Met Lys Lys Glu Gly Ile Gln Thr Arg Asn Arg Lys Met 
        355                 360                 365             


Ser Ser Lys Ser Lys Lys Cys Lys Lys Val His Asp Ser Leu Glu Asp 
    370                 375                 380                 


Phe Pro Lys Asn Ser Ser Phe Asn Pro Ala Ala Leu Ser Arg His Met 
385                 390                 395                 400 


Ser Ser Leu Ser His Ile Ser Pro Phe Ser His Ser Ser His Met Leu 
                405                 410                 415     


Thr Thr Pro Thr Pro Met His Pro Pro Ser Ser Leu Ser Phe Gly Pro 
            420                 425                 430         


His His Pro Ser Ser Met Val Thr Ala Met Gly 
        435                 440             


<210>  4353
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATA4__Homo_sapiens__NP_002043

<400>  4353

Met Tyr Gln Ser Leu Ala Met Ala Ala Asn His Gly Pro Pro Pro Gly 
1               5                   10                  15      


Ala Tyr Glu Ala Gly Gly Pro Gly Ala Phe Met His Gly Ala Gly Ala 
            20                  25                  30          


Ala Ser Ser Pro Val Tyr Val Pro Thr Pro Arg Val Pro Ser Ser Val 
        35                  40                  45              


Leu Gly Leu Ser Tyr Leu Gln Gly Gly Gly Ala Gly Ser Ala Ser Gly 
    50                  55                  60                  


Gly Ala Ser Gly Gly Ser Ser Gly Gly Ala Ala Ser Gly Ala Gly Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Gly Ser Pro Gly Trp Ser Gln Ala Gly Ala Asp Gly 
                85                  90                  95      


Ala Ala Tyr Thr Pro Pro Pro Val Ser Pro Arg Phe Ser Phe Pro Gly 
            100                 105                 110         


Thr Thr Gly Ser Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Glu 
        115                 120                 125             


Ala Ala Ala Tyr Ser Ser Gly Gly Gly Ala Ala Gly Ala Gly Leu Ala 
    130                 135                 140                 


Gly Arg Glu Gln Tyr Gly Arg Ala Gly Phe Ala Gly Ser Tyr Ser Ser 
145                 150                 155                 160 


Pro Tyr Pro Ala Tyr Met Ala Asp Val Gly Ala Ser Trp Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ser Ala Gly Pro Phe Asp Ser Pro Val Leu His Ser Leu 
            180                 185                 190         


Pro Gly Arg Ala Asn Pro Ala Ala Arg His Pro Asn Leu Asp Met Phe 
        195                 200                 205             


Asp Asp Phe Ser Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Met Ser 
    210                 215                 220                 


Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala 
225                 230                 235                 240 


Cys Gly Leu Tyr His Lys Met Asn Gly Ile Asn Arg Pro Leu Ile Lys 
                245                 250                 255     


Pro Gln Arg Arg Leu Ser Ala Ser Arg Arg Val Gly Leu Ser Cys Ala 
            260                 265                 270         


Asn Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly 
        275                 280                 285             


Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val 
    290                 295                 300                 


Pro Arg Pro Leu Ala Met Arg Lys Glu Gly Ile Gln Thr Arg Lys Arg 
305                 310                 315                 320 


Lys Pro Lys Asn Leu Asn Lys Ser Lys Thr Pro Ala Ala Pro Ser Gly 
                325                 330                 335     


Ser Glu Ser Leu Pro Pro Ala Ser Gly Ala Ser Ser Asn Ser Ser Asn 
            340                 345                 350         


Ala Thr Thr Ser Ser Ser Glu Glu Met Arg Pro Ile Lys Thr Glu Pro 
        355                 360                 365             


Gly Leu Ser Ser His Tyr Gly His Ser Ser Ser Val Ser Gln Thr Phe 
    370                 375                 380                 


Ser Val Ser Ala Met Ser Gly His Gly Pro Ser Ile His Pro Val Leu 
385                 390                 395                 400 


Ser Ala Leu Lys Leu Ser Pro Gln Gly Tyr Ala Ser Pro Val Ser Gln 
                405                 410                 415     


Ser Pro Gln Thr Ser Ser Lys Gln Asp Ser Trp Asn Ser Leu Val Leu 
            420                 425                 430         


Ala Asp Ser His Gly Asp Ile Ile Thr Ala 
        435                 440         


<210>  4354
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATA5__Homo_sapiens__XP_006723762

<400>  4354

Met Tyr Gln Ser Leu Ala Leu Ala Ala Ser Pro Arg Gln Ala Ala Tyr 
1               5                   10                  15      


Ala Asp Ser Gly Ser Phe Leu His Ala Pro Gly Ala Gly Ser Pro Met 
            20                  25                  30          


Phe Val Pro Pro Ala Arg Val Pro Ser Met Leu Ser Tyr Leu Ser Gly 
        35                  40                  45              


Cys Glu Pro Ser Pro Gln Pro Pro Glu Leu Ala Ala Arg Pro Gly Trp 
    50                  55                  60                  


Ala Gln Thr Ala Thr Ala Asp Ser Ser Ala Phe Gly Pro Gly Ser Pro 
65                  70                  75                  80  


His Pro Pro Ala Ala His Pro Pro Gly Ala Thr Ala Phe Pro Phe Ala 
                85                  90                  95      


His Ser Pro Ser Gly Pro Gly Ser Gly Gly Ser Ala Gly Gly Arg Asp 
            100                 105                 110         


Gly Ser Ala Tyr Gln Gly Ala Leu Leu Pro Arg Glu Gln Phe Ala Ala 
        115                 120                 125             


Pro Leu Gly Arg Pro Val Gly Thr Ser Tyr Ser Ala Thr Tyr Pro Ala 
    130                 135                 140                 


Tyr Val Ser Pro Asp Val Ala Gln Ser Trp Thr Ala Gly Pro Phe Asp 
145                 150                 155                 160 


Gly Ser Val Leu His Gly Leu Pro Gly Arg Arg Pro Thr Phe Val Ser 
                165                 170                 175     


Asp Phe Leu Glu Glu Phe Pro Gly Glu Gly Arg Glu Cys Val Asn Cys 
            180                 185                 190         


Gly Ala Leu Ser Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr 
        195                 200                 205             


Leu Cys Asn Ala Cys Gly Leu Tyr His Lys Met Asn Gly Val Asn Arg 
    210                 215                 220                 


Pro Leu Val Arg Pro Gln Lys Arg Leu Ser Ser Ser Arg Arg Ala Gly 
225                 230                 235                 240 


Leu Cys Cys Thr Asn Cys His Thr Thr Asn Thr Thr Leu Trp Arg Arg 
                245                 250                 255     


Asn Ser Glu Gly Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met Lys 
            260                 265                 270         


Leu His Gly Val Pro Arg Pro Leu Ala Met Lys Lys Glu Ser Ile Gln 
        275                 280                 285             


Thr Arg Lys Arg Lys Pro Lys Thr Ile Ala Lys Ala Arg Gly Ser Ser 
    290                 295                 300                 


Gly Ser Thr Arg Asn Ala Ser Ala Ser Pro Ser Ala Val Ala Ser Thr 
305                 310                 315                 320 


Asp Ser Ser Ala Ala Thr Ser Lys Ala Lys Pro Ser Leu Ala Ser Pro 
                325                 330                 335     


Val Cys Pro Gly Pro Ser Met Ala Pro Gln Ala Ser Gly Gln Glu Asp 
            340                 345                 350         


Asp Ser Leu Ala Pro Gly His Leu Glu Phe Lys Phe Glu Pro Glu Asp 
        355                 360                 365             


Phe Ala Phe Pro Ser Thr Ala Pro Ser Pro Gln Ala Gly Leu Arg Gly 
    370                 375                 380                 


Ala Leu Arg Gln Glu Ala Trp Cys Ala Leu Ala Leu Ala 
385                 390                 395         


<210>  4355
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATA6__Homo_sapiens__NP_005248

<400>  4355

Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      


Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala Arg Glu Pro 
            20                  25                  30          


Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              


Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly Thr Pro Gln 
    50                  55                  60                  


Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser Leu Leu Leu 
65                  70                  75                  80  


Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly Pro Ser Ala 
                85                  90                  95      


Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp Glu Asp Leu 
            100                 105                 110         


Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             


Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro Glu Gln Pro 
    130                 135                 140                 


Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 


Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         


Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser 
        195                 200                 205             


Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly 
    210                 215                 220                 


Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala 
                245                 250                 255     


Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala 
            260                 265                 270         


Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly 
        275                 280                 285             


Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly 
    290                 295                 300                 


Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn 
305                 310                 315                 320 


Gly Thr Tyr His His His His His His His His His His Pro Ser Pro 
                325                 330                 335     


Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly 
            340                 345                 350         


Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala 
        355                 360                 365             


Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu 
    370                 375                 380                 


Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu 
385                 390                 395                 400 


Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                405                 410                 415     


Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys 
            420                 425                 430         


Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His 
        435                 440                 445             


Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    450                 455                 460                 


Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
465                 470                 475                 480 


Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                485                 490                 495     


Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile 
            500                 505                 510         


Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys 
        515                 520                 525             


Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro 
    530                 535                 540                 


Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu 
545                 550                 555                 560 


Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser 
                565                 570                 575     


Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu 
            580                 585                 590         


Ala Leu Ala 
        595 


<210>  4356
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATAD1__Homo_sapiens__NP_066990

<400>  4356

Met Pro Leu Gly Leu Lys Pro Thr Cys Ser Val Cys Lys Thr Thr Ser 
1               5                   10                  15      


Ser Ser Met Trp Lys Lys Gly Ala Gln Gly Glu Ile Leu Cys His His 
            20                  25                  30          


Cys Thr Gly Arg Gly Gly Ala Gly Ser Gly Gly Ala Gly Ser Gly Ala 
        35                  40                  45              


Ala Gly Gly Thr Gly Gly Ser Gly Gly Gly Gly Phe Gly Ala Ala Thr 
    50                  55                  60                  


Phe Ala Ser Thr Ser Ala Thr Pro Pro Gln Ser Asn Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Lys Gln Ser Lys Gln Glu Ile His Arg Arg Ser Ala Arg Leu Arg 
                85                  90                  95      


Asn Thr Lys Tyr Lys Ser Ala Pro Ala Ala Glu Lys Lys Val Ser Thr 
            100                 105                 110         


Lys Gly Lys Gly Arg Arg His Ile Phe Lys Leu Lys Asn Pro Ile Lys 
        115                 120                 125             


Ala Pro Glu Ser Val Ser Thr Ile Ile Thr Ala Glu Ser Ile Phe Tyr 
    130                 135                 140                 


Lys Gly Val Tyr Tyr Gln Ile Gly Asp Val Val Ser Val Ile Asp Glu 
145                 150                 155                 160 


Gln Asp Gly Lys Pro Tyr Tyr Ala Gln Ile Arg Gly Phe Ile Gln Asp 
                165                 170                 175     


Gln Tyr Cys Glu Lys Ser Ala Ala Leu Thr Trp Leu Ile Pro Thr Leu 
            180                 185                 190         


Ser Ser Pro Arg Asp Gln Phe Asp Pro Ala Ser Tyr Ile Ile Gly Pro 
        195                 200                 205             


Glu Glu Asp Leu Pro Arg Lys Met Glu Tyr Leu Glu Phe Val Cys His 
    210                 215                 220                 


Ala Pro Ser Glu Tyr Phe Lys Ser Arg Ser Ser Pro Phe Pro Thr Val 
225                 230                 235                 240 


Pro Thr Arg Pro Glu Lys Gly Tyr Ile Trp Thr His Val Gly Pro Thr 
                245                 250                 255     


Pro Ala Ile Thr Ile Lys Glu Ser Val Ala Asn His Leu 
            260                 265                 


<210>  4357
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATAD2A__Homo_sapiens__NP_001287875

<400>  4357

Met Thr Glu Glu Ala Cys Arg Thr Arg Ser Gln Lys Arg Ala Leu Glu 
1               5                   10                  15      


Arg Asp Pro Thr Glu Asp Asp Val Glu Ser Lys Lys Ile Lys Met Glu 
            20                  25                  30          


Arg Gly Leu Leu Ala Ser Asp Leu Asn Thr Asp Gly Asp Met Arg Val 
        35                  40                  45              


Thr Pro Glu Pro Gly Ala Gly Pro Thr Gln Gly Leu Leu Arg Ala Thr 
    50                  55                  60                  


Glu Ala Thr Ala Met Ala Met Gly Arg Gly Glu Gly Leu Val Gly Asp 
65                  70                  75                  80  


Gly Pro Val Asp Met Arg Thr Ser His Ser Asp Met Lys Ser Glu Arg 
                85                  90                  95      


Arg Pro Pro Ser Pro Asp Val Ile Val Leu Ser Asp Asn Glu Gln Pro 
            100                 105                 110         


Ser Ser Pro Arg Val Asn Gly Leu Thr Thr Val Ala Leu Lys Glu Thr 
        115                 120                 125             


Ser Thr Glu Ala Leu Met Lys Ser Ser Pro Glu Glu Arg Glu Arg Met 
    130                 135                 140                 


Ile Lys Gln Leu Lys Glu Glu Leu Arg Leu Glu Glu Ala Lys Leu Val 
145                 150                 155                 160 


Leu Leu Lys Lys Leu Arg Gln Ser Gln Ile Gln Lys Glu Ala Thr Ala 
                165                 170                 175     


Gln Lys Pro Thr Gly Ser Val Gly Ser Thr Val Thr Thr Pro Pro Pro 
            180                 185                 190         


Leu Val Arg Gly Thr Gln Asn Ile Pro Ala Gly Lys Pro Ser Leu Gln 
        195                 200                 205             


Thr Ser Ser Ala Arg Met Pro Gly Ser Val Ile Pro Pro Pro Leu Val 
    210                 215                 220                 


Arg Gly Gly Gln Gln Ala Ser Ser Lys Leu Gly Pro Gln Ala Ser Ser 
225                 230                 235                 240 


Gln Val Val Met Pro Pro Leu Val Arg Gly Ala Gln Gln Ile His Ser 
                245                 250                 255     


Ile Arg Gln His Ser Ser Thr Gly Pro Pro Pro Leu Leu Leu Ala Pro 
            260                 265                 270         


Arg Ala Ser Val Pro Ser Val Gln Ile Gln Gly Gln Arg Ile Ile Gln 
        275                 280                 285             


Gln Gly Leu Ile Arg Val Ala Asn Val Pro Asn Thr Ser Leu Leu Val 
    290                 295                 300                 


Asn Ile Pro Gln Pro Thr Pro Ala Ser Leu Lys Gly Thr Thr Ala Thr 
305                 310                 315                 320 


Ser Ala Gln Ala Asn Ser Thr Pro Thr Ser Val Ala Ser Val Val Thr 
                325                 330                 335     


Ser Ala Glu Ser Pro Ala Ser Arg Gln Ala Ala Ala Lys Leu Ala Leu 
            340                 345                 350         


Arg Lys Gln Leu Glu Lys Thr Leu Leu Glu Ile Pro Pro Pro Lys Pro 
        355                 360                 365             


Pro Ala Pro Glu Met Asn Phe Leu Pro Ser Ala Ala Asn Asn Glu Phe 
    370                 375                 380                 


Ile Tyr Leu Val Gly Leu Glu Glu Val Val Gln Asn Leu Leu Glu Thr 
385                 390                 395                 400 


Gln Ala Gly Arg Met Ser Ala Ala Thr Val Leu Ser Arg Glu Pro Tyr 
                405                 410                 415     


Met Cys Ala Gln Cys Lys Thr Asp Phe Thr Cys Arg Trp Arg Glu Glu 
            420                 425                 430         


Lys Ser Gly Ala Ile Met Cys Glu Asn Cys Met Thr Thr Asn Gln Lys 
        435                 440                 445             


Lys Ala Leu Lys Val Glu His Thr Ser Arg Leu Lys Ala Ala Phe Val 
    450                 455                 460                 


Lys Ala Leu Gln Gln Glu Gln Glu Ile Glu Gln Arg Leu Leu Gln Gln 
465                 470                 475                 480 


Gly Thr Ala Pro Ala Gln Ala Lys Ala Glu Pro Thr Ala Ala Pro His 
                485                 490                 495     


Pro Val Leu Lys Gln Val Ile Lys Pro Arg Arg Lys Leu Ala Phe Arg 
            500                 505                 510         


Ser Gly Glu Ala Arg Asp Trp Ser Asn Gly Ala Val Leu Gln Ala Ser 
        515                 520                 525             


Ser Gln Leu Ser Arg Gly Ser Ala Thr Thr Pro Arg Gly Val Leu His 
    530                 535                 540                 


Thr Phe Ser Pro Ser Pro Lys Leu Gln Asn Ser Ala Ser Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ser Arg Thr Gly Arg His Ser Glu Arg Thr Val Ser Ala Gly 
                565                 570                 575     


Lys Gly Ser Ala Thr Ser Asn Trp Lys Lys Thr Pro Leu Ser Thr Gly 
            580                 585                 590         


Gly Thr Leu Ala Phe Val Ser Pro Ser Leu Ala Val His Lys Ser Ser 
        595                 600                 605             


Ser Ala Val Asp Arg Gln Arg Glu Tyr Leu Leu Asp Met Ile Pro Pro 
    610                 615                 620                 


Arg Ser Ile Pro Gln Ser Ala Thr Trp Lys 
625                 630                 


<210>  4358
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATAD2B__Homo_sapiens__XP_006711532

<400>  4358

Met Asp Arg Met Thr Glu Asp Ala Leu Arg Leu Asn Leu Leu Lys Arg 
1               5                   10                  15      


Ser Leu Asp Pro Ala Asp Glu Arg Asp Asp Val Leu Ala Lys Arg Leu 
            20                  25                  30          


Lys Met Glu Gly His Glu Ala Met Glu Arg Leu Lys Met Leu Ala Leu 
        35                  40                  45              


Leu Lys Arg Lys Asp Leu Ala Asn Leu Glu Val Pro His Glu Leu Pro 
    50                  55                  60                  


Thr Lys Gln Asp Gly Ser Gly Val Lys Gly Tyr Glu Glu Lys Leu Asn 
65                  70                  75                  80  


Gly Asn Leu Arg Pro His Gly Asp Asn Arg Thr Ala Gly Arg Pro Gly 
                85                  90                  95      


Lys Glu Asn Ile Asn Asp Glu Pro Val Asp Met Ser Ala Arg Arg Ser 
            100                 105                 110         


Glu Pro Glu Arg Gly Arg Leu Thr Pro Ser Pro Asp Ile Ile Val Leu 
        115                 120                 125             


Ser Asp Asn Glu Ala Ser Ser Pro Arg Ser Ser Ser Arg Met Glu Glu 
    130                 135                 140                 


Arg Leu Lys Ala Ala Asn Leu Glu Met Phe Lys Gly Lys Gly Ile Glu 
145                 150                 155                 160 


Glu Arg Gln Gln Leu Ile Lys Gln Leu Arg Asp Glu Leu Arg Leu Glu 
                165                 170                 175     


Glu Ala Arg Leu Val Leu Leu Lys Lys Leu Arg Gln Ser Gln Leu Gln 
            180                 185                 190         


Lys Glu Asn Val Val Gln Lys Thr Pro Val Val Gln Asn Ala Ala Ser 
        195                 200                 205             


Ile Val Gln Pro Ser Pro Ala His Val Gly Gln Gln Gly Leu Ser Lys 
    210                 215                 220                 


Leu Pro Ser Arg Pro Gly Ala Gln Gly Val Glu Pro Gln Asn Leu Arg 
225                 230                 235                 240 


Thr Leu Gln Gly His Ser Val Ile Arg Ser Ala Thr Asn Thr Thr Leu 
                245                 250                 255     


Pro His Met Leu Met Ser Gln Arg Val Ile Ala Pro Asn Pro Ala Gln 
            260                 265                 270         


Leu Gln Gly Gln Arg Gly Pro Pro Lys Pro Gly Leu Val Arg Thr Thr 
        275                 280                 285             


Thr Pro Asn Met Asn Pro Ala Ile Asn Tyr Gln Pro Gln Ser Ser Ser 
    290                 295                 300                 


Ser Val Pro Cys Gln Arg Thr Thr Ser Ser Ala Ile Tyr Met Asn Leu 
305                 310                 315                 320 


Ala Ser His Ile Gln Pro Gly Thr Val Asn Arg Val Ser Ser Pro Leu 
                325                 330                 335     


Pro Ser Pro Ser Ala Met Thr Asp Ala Ala Asn Ser Gln Ala Ala Ala 
            340                 345                 350         


Lys Leu Ala Leu Arg Lys Gln Leu Glu Lys Thr Leu Leu Glu Ile Pro 
        355                 360                 365             


Pro Pro Lys Pro Pro Ala Pro Leu Leu His Phe Leu Pro Ser Ala Ala 
    370                 375                 380                 


Asn Ser Glu Phe Ile Tyr Met Val Gly Leu Glu Glu Val Val Gln Ser 
385                 390                 395                 400 


Val Ile Asp Ser Gln Gly Lys Ser Cys Ala Ser Leu Leu Arg Val Glu 
                405                 410                 415     


Pro Phe Val Cys Ala Gln Cys Arg Thr Asp Phe Thr Pro His Trp Lys 
            420                 425                 430         


Gln Glu Lys Asn Gly Lys Ile Leu Cys Glu Gln Cys Met Thr Ser Asn 
        435                 440                 445             


Gln Lys Lys Ala Leu Lys Ala Glu His Thr Asn Arg Leu Lys Asn Ala 
    450                 455                 460                 


Phe Val Lys Ala Leu Gln Gln Glu Gln Glu Ile Glu Gln Arg Leu Gln 
465                 470                 475                 480 


Gln Gln Ala Ala Leu Ser Pro Thr Thr Ala Pro Ala Val Ser Ser Val 
                485                 490                 495     


Ser Lys Gln Glu Thr Ile Met Arg His His Thr Leu Arg Gln Ala Pro 
            500                 505                 510         


Gln Pro Gln Ser Ser Leu Gln Arg Gly Ile Pro Thr Ser Ala Arg Ser 
        515                 520                 525             


Met Leu Ser Asn Phe Ala Gln Ala Pro Gln Leu Ser Val Pro Gly Gly 
    530                 535                 540                 


Leu Leu Gly Met Pro Gly Val Asn Ile Ala Tyr Leu Asn Thr Gly Ile 
545                 550                 555                 560 


Gly Gly His Lys Gly Pro Ser Leu Ala Asp Arg Gln Arg Glu Tyr Leu 
                565                 570                 575     


Leu Asp Met Ile Pro Pro Arg Ser Ile Ser Gln Ser Ile Ser Gly Gln 
            580                 585                 590         


Lys 
    


<210>  4359
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATB__Homo_sapiens__NP_004555

<400>  4359

Met Ala Ala Pro Met Leu Arg Trp Gly Cys Arg Gly Arg Arg Trp Ala 
1               5                   10                  15      


Phe Ala Arg Val Asp Gly Gly Ser Cys His Arg Arg Gly Ala Pro Thr 
            20                  25                  30          


Gly Ser Thr Ser Asn Gln Ile Arg Gly Glu Ser Ser Val Ala Gln Gln 
        35                  40                  45              


Pro Leu His Thr Ala Gln Lys Thr Arg Lys Gly Glu His Lys Trp Ala 
    50                  55                  60                  


Ala Val Val Gly Leu Glu Ile His Ala Gln Ile Ser Ser Asn Ser Lys 
65                  70                  75                  80  


Leu Phe Ser Gly Ser Gln Val Arg Phe Ser Ala Pro Pro Asn Ser Leu 
                85                  90                  95      


Val Ser Phe Phe Asp Ala Ser Leu Pro Gly Thr Leu Pro Val Leu Asn 
            100                 105                 110         


Arg Arg Cys Val Glu Ala Ala Val Met Thr Gly Leu Ala Leu Asn Cys 
        115                 120                 125             


His Ile Asn Lys Lys Ser Leu Phe Asp Arg Lys His Tyr Phe Tyr Ala 
    130                 135                 140                 


Asp Leu Pro Ala Gly Tyr Gln Ile Thr Gln Gln Arg Leu Pro Ile Ala 
145                 150                 155                 160 


Val Asn Gly Ser Leu Ile Tyr Gly Val Cys Ala Gly Lys Lys Gln Ser 
                165                 170                 175     


Gln Val Ile Pro Lys Thr Val Arg Ile Lys Gln Ile Gln Leu Glu Gln 
            180                 185                 190         


Asp Ser Gly Lys Ser Leu His Asp Asn Leu Arg Ser Gln Thr Leu Ile 
        195                 200                 205             


Asp Leu Asn Arg Ala Gly Val Gly Leu Leu Glu Val Val Leu Glu Pro 
    210                 215                 220                 


Asp Met Ser Cys Gly Glu Glu Ala Ala Thr Ala Val Arg Glu Leu Gln 
225                 230                 235                 240 


Leu Ile Leu Gln Ala Leu Gly Thr Ser Gln Ala Asn Met Ala Glu Gly 
                245                 250                 255     


Gln Leu Arg Val Asp Ala Asn Ile Ser Val His His Pro Gly Glu Pro 
            260                 265                 270         


Leu Gly Val Arg Thr Glu Val Lys Asn Leu Asn Ser Ile Arg Phe Leu 
        275                 280                 285             


Ala Lys Ala Ile Asp Tyr Glu Ile Gln Arg Gln Ile Asn Glu Leu Glu 
    290                 295                 300                 


Asn Gly Gly Glu Ile Leu Asn Glu Thr Arg Ser Phe His His Lys Leu 
305                 310                 315                 320 


Gly Cys Thr Met Ser Met Arg Asp Lys Glu Gly Lys Gln Asp Tyr Arg 
                325                 330                 335     


Phe Met Pro Glu Pro Asn Leu Pro Pro Leu Val Leu Tyr Asp Ala Thr 
            340                 345                 350         


Ser Leu Pro Ala Gly Ala Asp Pro Gln Gln Val Ile Asn Ile Asp Gln 
        355                 360                 365             


Ile Arg Glu Thr Leu Pro Glu Leu Pro Ser Val Thr Arg Glu Lys Leu 
    370                 375                 380                 


Val Gln Gln Tyr Gly Met Leu Leu Glu His Ser Phe Thr Leu Leu Asn 
385                 390                 395                 400 


Glu Val Gly Leu Leu Glu Phe Phe Gln Asn Val Ile Lys Glu Thr Arg 
                405                 410                 415     


Ala Glu Pro Lys Lys Val Thr Ser Trp Val Leu Asn Thr Phe Leu Gly 
            420                 425                 430         


Tyr Leu Lys Gln Gln Asn Leu Ala Val Ser Glu Ser Pro Val Thr Pro 
        435                 440                 445             


Ser Ala Leu Ala Glu Leu Leu Asp Leu Leu Asp Ser Arg Thr Ile Ser 
    450                 455                 460                 


Ser Ser Ala Ala Lys Gln Val Phe Glu Glu Leu Trp Lys Arg Glu Gly 
465                 470                 475                 480 


Lys Thr Pro Gly Gln Ile Val Ser Glu Lys Gln Leu Glu Leu Met Gln 
                485                 490                 495     


Asp Gln Gly Ala Leu Glu Gln Leu Cys His Ser Val Met Glu Ala His 
            500                 505                 510         


Pro Gln Val Val Met Asp Val Lys Asn Arg Asn Pro Arg Ala Ile Asn 
        515                 520                 525             


Lys Leu Ile Gly Leu Val Arg Lys Ala Thr Gln Ser Arg Ala Asp Pro 
    530                 535                 540                 


Val Met Ile Lys Glu Ile Leu Glu Lys Lys Leu Ser Leu 
545                 550                 555         


<210>  4360
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GATM__Homo_sapiens__NP_001473

<400>  4360

Met Leu Arg Val Arg Cys Leu Arg Gly Gly Ser Arg Gly Ala Glu Ala 
1               5                   10                  15      


Val His Tyr Ile Gly Ser Arg Leu Gly Arg Thr Leu Thr Gly Trp Val 
            20                  25                  30          


Gln Arg Thr Phe Gln Ser Thr Gln Ala Ala Thr Ala Ser Ser Arg Asn 
        35                  40                  45              


Ser Cys Ala Ala Asp Asp Lys Ala Thr Glu Pro Leu Pro Lys Asp Cys 
    50                  55                  60                  


Pro Val Ser Ser Tyr Asn Glu Trp Asp Pro Leu Glu Glu Val Ile Val 
65                  70                  75                  80  


Gly Arg Ala Glu Asn Ala Cys Val Pro Pro Phe Thr Ile Glu Val Lys 
                85                  90                  95      


Ala Asn Thr Tyr Glu Lys Tyr Trp Pro Phe Tyr Gln Lys Gln Gly Gly 
            100                 105                 110         


His Tyr Phe Pro Lys Asp His Leu Lys Lys Ala Val Ala Glu Ile Glu 
        115                 120                 125             


Glu Met Cys Asn Ile Leu Lys Thr Glu Gly Val Thr Val Arg Arg Pro 
    130                 135                 140                 


Asp Pro Ile Asp Trp Ser Leu Lys Tyr Lys Thr Pro Asp Phe Glu Ser 
145                 150                 155                 160 


Thr Gly Leu Tyr Ser Ala Met Pro Arg Asp Ile Leu Ile Val Val Gly 
                165                 170                 175     


Asn Glu Ile Ile Glu Ala Pro Met Ala Trp Arg Ser Arg Phe Phe Glu 
            180                 185                 190         


Tyr Arg Ala Tyr Arg Ser Ile Ile Lys Asp Tyr Phe His Arg Gly Ala 
        195                 200                 205             


Lys Trp Thr Thr Ala Pro Lys Pro Thr Met Ala Asp Glu Leu Tyr Asn 
    210                 215                 220                 


Gln Asp Tyr Pro Ile His Ser Val Glu Asp Arg His Lys Leu Ala Ala 
225                 230                 235                 240 


Gln Gly Lys Phe Val Thr Thr Glu Phe Glu Pro Cys Phe Asp Ala Ala 
                245                 250                 255     


Asp Phe Ile Arg Ala Gly Arg Asp Ile Phe Ala Gln Arg Ser Gln Val 
            260                 265                 270         


Thr Asn Tyr Leu Gly Ile Glu Trp Met Arg Arg His Leu Ala Pro Asp 
        275                 280                 285             


Tyr Arg Val His Ile Ile Ser Phe Lys Asp Pro Asn Pro Met His Ile 
    290                 295                 300                 


Asp Ala Thr Phe Asn Ile Ile Gly Pro Gly Ile Val Leu Ser Asn Pro 
305                 310                 315                 320 


Asp Arg Pro Cys His Gln Ile Asp Leu Phe Lys Lys Ala Gly Trp Thr 
                325                 330                 335     


Ile Ile Thr Pro Pro Thr Pro Ile Ile Pro Asp Asp His Pro Leu Trp 
            340                 345                 350         


Met Ser Ser Lys Trp Leu Ser Met Asn Val Leu Met Leu Asp Glu Lys 
        355                 360                 365             


Arg Val Met Val Asp Ala Asn Glu Val Pro Ile Gln Lys Met Phe Glu 
    370                 375                 380                 


Lys Leu Gly Ile Thr Thr Ile Lys Val Asn Ile Arg Asn Ala Asn Ser 
385                 390                 395                 400 


Leu Gly Gly Gly Phe His Cys Trp Thr Cys Asp Val Arg Arg Arg Gly 
                405                 410                 415     


Thr Leu Gln Ser Tyr Leu Asp 
            420             


<210>  4361
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBA2__Homo_sapiens__NP_065995

<400>  4361

Met Gly Thr Gln Asp Pro Gly Asn Met Gly Thr Gly Val Pro Ala Ser 
1               5                   10                  15      


Glu Gln Ile Ser Cys Ala Lys Glu Asp Pro Gln Val Tyr Cys Pro Glu 
            20                  25                  30          


Glu Thr Gly Gly Thr Lys Asp Val Gln Val Thr Asp Cys Lys Ser Pro 
        35                  40                  45              


Glu Asp Ser Arg Pro Pro Lys Glu Thr Asp Cys Cys Asn Pro Glu Asp 
    50                  55                  60                  


Ser Gly Gln Leu Met Val Ser Tyr Glu Gly Lys Ala Met Gly Tyr Gln 
65                  70                  75                  80  


Val Pro Pro Phe Gly Trp Arg Ile Cys Leu Ala His Glu Phe Thr Glu 
                85                  90                  95      


Lys Arg Lys Pro Phe Gln Ala Asn Asn Val Ser Leu Ser Asn Met Ile 
            100                 105                 110         


Lys His Ile Gly Met Gly Leu Arg Tyr Leu Gln Trp Trp Tyr Arg Lys 
        115                 120                 125             


Thr His Val Glu Lys Lys Thr Pro Phe Ile Asp Met Ile Asn Ser Val 
    130                 135                 140                 


Pro Leu Arg Gln Ile Tyr Gly Cys Pro Leu Gly Gly Ile Gly Gly Gly 
145                 150                 155                 160 


Thr Ile Thr Arg Gly Trp Arg Gly Gln Phe Cys Arg Trp Gln Leu Asn 
                165                 170                 175     


Pro Gly Met Tyr Gln His Arg Thr Val Ile Ala Asp Gln Phe Thr Val 
            180                 185                 190         


Cys Leu Arg Arg Glu Gly Gln Thr Val Tyr Gln Gln Val Leu Ser Leu 
        195                 200                 205             


Glu Arg Pro Ser Val Leu Arg Ser Trp Asn Trp Gly Leu Cys Gly Tyr 
    210                 215                 220                 


Phe Ala Phe Tyr His Ala Leu Tyr Pro Arg Ala Trp Thr Val Tyr Gln 
225                 230                 235                 240 


Leu Pro Gly Gln Asn Val Thr Leu Thr Cys Arg Gln Ile Thr Pro Ile 
                245                 250                 255     


Leu Pro His Asp Tyr Gln Asp Ser Ser Leu Pro Val Gly Val Phe Val 
            260                 265                 270         


Trp Asp Val Glu Asn Glu Gly Asp Glu Ala Leu Asp Val Ser Ile Met 
        275                 280                 285             


Phe Ser Met Arg Asn Gly Leu Gly Gly Gly Asp Asp Ala Pro Gly Gly 
    290                 295                 300                 


Leu Trp Asn Glu Pro Phe Cys Leu Glu Arg Ser Gly Glu Thr Val Arg 
305                 310                 315                 320 


Gly Leu Leu Leu His His Pro Thr Leu Pro Asn Pro Tyr Thr Met Ala 
                325                 330                 335     


Val Ala Ala Arg Val Thr Ala Ala Thr Thr Val Thr His Ile Thr Ala 
            340                 345                 350         


Phe Asp Pro Asp Ser Thr Gly Gln Gln Val Trp Gln Asp Leu Leu Gln 
        355                 360                 365             


Asp Gly Gln Leu Asp Ser Pro Thr Gly Gln Ser Thr Pro Thr Gln Lys 
    370                 375                 380                 


Gly Val Gly Ile Ala Gly Ala Val Cys Val Ser Ser Lys Leu Arg Pro 
385                 390                 395                 400 


Arg Gly Gln Cys Arg Leu Glu Phe Ser Leu Ala Trp Asp Met Pro Arg 
                405                 410                 415     


Ile Met Phe Gly Ala Lys Gly Gln Val His Tyr Arg Arg Tyr Thr Arg 
            420                 425                 430         


Phe Phe Gly Gln Asp Gly Asp Ala Ala Pro Ala Leu Ser His Tyr Ala 
        435                 440                 445             


Leu Cys Arg Tyr Ala Glu Trp Glu Glu Arg Ile Ser Ala Trp Gln Ser 
    450                 455                 460                 


Pro Val Leu Asp Asp Arg Ser Leu Pro Ala Trp Tyr Lys Ser Ala Leu 
465                 470                 475                 480 


Phe Asn Glu Leu Tyr Phe Leu Ala Asp Gly Gly Thr Val Trp Leu Glu 
                485                 490                 495     


Val Leu Glu Asp Ser Leu Pro Glu Glu Leu Gly Arg Asn Met Cys His 
            500                 505                 510         


Leu Arg Pro Thr Leu Arg Asp Tyr Gly Arg Phe Gly Tyr Leu Glu Gly 
        515                 520                 525             


Gln Glu Tyr Arg Met Tyr Asn Thr Tyr Asp Val His Phe Tyr Ala Ser 
    530                 535                 540                 


Phe Ala Leu Ile Met Leu Trp Pro Lys Leu Glu Leu Ser Leu Gln Tyr 
545                 550                 555                 560 


Asp Met Ala Leu Ala Thr Leu Arg Glu Asp Leu Thr Arg Arg Arg Tyr 
                565                 570                 575     


Leu Met Ser Gly Val Met Ala Pro Val Lys Arg Arg Asn Val Ile Pro 
            580                 585                 590         


His Asp Ile Gly Asp Pro Asp Asp Glu Pro Trp Leu Arg Val Asn Ala 
        595                 600                 605             


Tyr Leu Ile His Asp Thr Ala Asp Trp Lys Asp Leu Asn Leu Lys Phe 
    610                 615                 620                 


Val Leu Gln Val Tyr Arg Asp Tyr Tyr Leu Thr Gly Asp Gln Asn Phe 
625                 630                 635                 640 


Leu Lys Asp Met Trp Pro Val Cys Leu Ala Val Met Glu Ser Glu Met 
                645                 650                 655     


Lys Phe Asp Lys Asp His Asp Gly Leu Ile Glu Asn Gly Gly Tyr Ala 
            660                 665                 670         


Asp Gln Thr Tyr Asp Gly Trp Val Thr Thr Gly Pro Ser Ala Tyr Cys 
        675                 680                 685             


Gly Gly Leu Trp Leu Ala Ala Val Ala Val Met Val Gln Met Ala Ala 
    690                 695                 700                 


Leu Cys Gly Ala Gln Asp Ile Gln Asp Lys Phe Ser Ser Ile Leu Ser 
705                 710                 715                 720 


Arg Gly Gln Glu Ala Tyr Glu Arg Leu Leu Trp Asn Gly Arg Tyr Tyr 
                725                 730                 735     


Asn Tyr Asp Ser Ser Ser Arg Pro Gln Ser Arg Ser Val Met Ser Asp 
            740                 745                 750         


Gln Cys Ala Gly Gln Trp Phe Leu Lys Ala Cys Gly Leu Gly Glu Gly 
        755                 760                 765             


Asp Thr Glu Val Phe Pro Thr Gln His Val Val Arg Ala Leu Gln Thr 
    770                 775                 780                 


Ile Phe Glu Leu Asn Val Gln Ala Phe Ala Gly Gly Ala Met Gly Ala 
785                 790                 795                 800 


Val Asn Gly Met Gln Pro His Gly Val Pro Asp Lys Ser Ser Val Gln 
                805                 810                 815     


Ser Asp Glu Val Trp Val Gly Val Val Tyr Gly Leu Ala Ala Thr Met 
            820                 825                 830         


Ile Gln Glu Gly Leu Thr Trp Glu Gly Phe Gln Thr Ala Glu Gly Cys 
        835                 840                 845             


Tyr Arg Thr Val Trp Glu Arg Leu Gly Leu Ala Phe Gln Thr Pro Glu 
    850                 855                 860                 


Ala Tyr Cys Gln Gln Arg Val Phe Arg Ser Leu Ala Tyr Met Arg Pro 
865                 870                 875                 880 


Leu Ser Ile Trp Ala Met Gln Leu Ala Leu Gln Gln Gln Gln His Lys 
                885                 890                 895     


Lys Ala Ser Trp Pro Lys Val Lys Gln Gly Thr Gly Leu Arg Thr Gly 
            900                 905                 910         


Pro Met Phe Gly Pro Lys Glu Ala Met Ala Asn Leu Ser Pro Glu 
        915                 920                 925         


<210>  4362
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBA__Homo_sapiens__NP_001165282

<400>  4362

Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
1               5                   10                  15      


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
            20                  25                  30          


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
        35                  40                  45              


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
    50                  55                  60                  


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
65                  70                  75                  80  


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
                85                  90                  95      


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
            100                 105                 110         


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
        115                 120                 125             


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
    130                 135                 140                 


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
145                 150                 155                 160 


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
                165                 170                 175     


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
            180                 185                 190         


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
        195                 200                 205             


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
    210                 215                 220                 


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
225                 230                 235                 240 


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
                245                 250                 255     


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
            260                 265                 270         


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
        275                 280                 285             


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
    290                 295                 300                 


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
305                 310                 315                 320 


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
                325                 330                 335     


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
            340                 345                 350         


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
        355                 360                 365             


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
    370                 375                 380                 


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
385                 390                 395                 400 


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
                405                 410                 415     


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
            420                 425                 430         


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
        435                 440                 445             


Gln 
    


<210>  4363
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBAS__Homo_sapiens__NP_001189398

<400>  4363

Met Ala Ala Arg Val Leu Arg Ala Arg Gly Ala Ala Trp Ala Gly Gly 
1               5                   10                  15      


Leu Leu Gln Arg Ala Ala Pro Cys Ser Leu Leu Pro Arg Leu Arg Thr 
            20                  25                  30          


Trp Thr Ser Ser Ser Asn Arg Ser Arg Glu Asp Ser Trp Leu Lys Ser 
        35                  40                  45              


Leu Phe Val Arg Lys Val Asp Pro Arg Lys Asp Ala His Ser Asn Leu 
    50                  55                  60                  


Leu Ala Lys Lys Glu Thr Ser Asn Leu Tyr Lys Leu Gln Phe Lys Arg 
65                  70                  75                  80  


Cys Cys Gln Arg Phe Thr Lys Ile Asn Thr Thr Leu Val Leu Trp Trp 
                85                  90                  95      


Gly Leu Gly Thr Arg Gly Met Ala Ser Arg Thr Lys Leu Glu Phe Leu 
            100                 105                 110         


Glu Phe Arg Lys Ala Arg Ser Asp Met Leu Leu Ser Arg Lys Asn Gln 
        115                 120                 125             


Leu Leu Leu Glu Phe Ser Phe Trp Asn Glu Pro Val Pro Arg Ser Gly 
    130                 135                 140                 


Pro Asn Ile Tyr Glu Leu Arg Ser Tyr Gln Leu Arg Pro Gly Thr Met 
145                 150                 155                 160 


Ile Glu Trp Gly Asn Tyr Trp Ala Arg Ala Ile Arg Phe Arg Gln Asp 
                165                 170                 175     


Gly Asn Glu Ala Val Gly Gly Phe Phe Ser Gln Ile Gly Gln Leu Tyr 
            180                 185                 190         


Met Val His His Leu Trp Ala Tyr Arg Asp Leu Gln Thr Arg Glu Asp 
        195                 200                 205             


Ile Arg Asn Ala Ala Trp His Lys His Gly Trp Glu Glu Leu Val Tyr 
    210                 215                 220                 


Tyr Thr Val Pro Leu Ile Gln Glu Met Glu Ser Arg Ile Met Ile Pro 
225                 230                 235                 240 


Leu Lys Thr Ser Pro Leu Gln 
                245         


<210>  4364
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBE1__Homo_sapiens__NP_000149

<400>  4364

Met Ala Ala Pro Met Thr Pro Ala Ala Arg Pro Glu Asp Tyr Glu Ala 
1               5                   10                  15      


Ala Leu Asn Ala Ala Leu Ala Asp Val Pro Glu Leu Ala Arg Leu Leu 
            20                  25                  30          


Glu Ile Asp Pro Tyr Leu Lys Pro Tyr Ala Val Asp Phe Gln Arg Arg 
        35                  40                  45              


Tyr Lys Gln Phe Ser Gln Ile Leu Lys Asn Ile Gly Glu Asn Glu Gly 
    50                  55                  60                  


Gly Ile Asp Lys Phe Ser Arg Gly Tyr Glu Ser Phe Gly Val His Arg 
65                  70                  75                  80  


Cys Ala Asp Gly Gly Leu Tyr Cys Lys Glu Trp Ala Pro Gly Ala Glu 
                85                  90                  95      


Gly Val Phe Leu Thr Gly Asp Phe Asn Gly Trp Asn Pro Phe Ser Tyr 
            100                 105                 110         


Pro Tyr Lys Lys Leu Asp Tyr Gly Lys Trp Glu Leu Tyr Ile Pro Pro 
        115                 120                 125             


Lys Gln Asn Lys Ser Val Leu Val Pro His Gly Ser Lys Leu Lys Val 
    130                 135                 140                 


Val Ile Thr Ser Lys Ser Gly Glu Ile Leu Tyr Arg Ile Ser Pro Trp 
145                 150                 155                 160 


Ala Lys Tyr Val Val Arg Glu Gly Asp Asn Val Asn Tyr Asp Trp Ile 
                165                 170                 175     


His Trp Asp Pro Glu His Ser Tyr Glu Phe Lys His Ser Arg Pro Lys 
            180                 185                 190         


Lys Pro Arg Ser Leu Arg Ile Tyr Glu Ser His Val Gly Ile Ser Ser 
        195                 200                 205             


His Glu Gly Lys Val Ala Ser Tyr Lys His Phe Thr Cys Asn Val Leu 
    210                 215                 220                 


Pro Arg Ile Lys Gly Leu Gly Tyr Asn Cys Ile Gln Leu Met Ala Ile 
225                 230                 235                 240 


Met Glu His Ala Tyr Tyr Ala Ser Phe Gly Tyr Gln Ile Thr Ser Phe 
                245                 250                 255     


Phe Ala Ala Ser Ser Arg Tyr Gly Thr Pro Glu Glu Leu Gln Glu Leu 
            260                 265                 270         


Val Asp Thr Ala His Ser Met Gly Ile Ile Val Leu Leu Asp Val Val 
        275                 280                 285             


His Ser His Ala Ser Lys Asn Ser Ala Asp Gly Leu Asn Met Phe Asp 
    290                 295                 300                 


Gly Thr Asp Ser Cys Tyr Phe His Ser Gly Pro Arg Gly Thr His Asp 
305                 310                 315                 320 


Leu Trp Asp Ser Arg Leu Phe Ala Tyr Ser Ser Trp Glu Val Leu Arg 
                325                 330                 335     


Phe Leu Leu Ser Asn Ile Arg Trp Trp Leu Glu Glu Tyr Arg Phe Asp 
            340                 345                 350         


Gly Phe Arg Phe Asp Gly Val Thr Ser Met Leu Tyr His His His Gly 
        355                 360                 365             


Val Gly Gln Gly Phe Ser Gly Asp Tyr Ser Glu Tyr Phe Gly Leu Gln 
    370                 375                 380                 


Val Asp Glu Asp Ala Leu Thr Tyr Leu Met Leu Ala Asn His Leu Val 
385                 390                 395                 400 


His Thr Leu Cys Pro Asp Ser Ile Thr Ile Ala Glu Asp Val Ser Gly 
                405                 410                 415     


Met Pro Ala Leu Cys Ser Pro Ile Ser Gln Gly Gly Gly Gly Phe Asp 
            420                 425                 430         


Tyr Arg Leu Ala Met Ala Ile Pro Asp Lys Trp Ile Gln Leu Leu Lys 
        435                 440                 445             


Glu Phe Lys Asp Glu Asp Trp Asn Met Gly Asp Ile Val Tyr Thr Leu 
    450                 455                 460                 


Thr Asn Arg Arg Tyr Leu Glu Lys Cys Ile Ala Tyr Ala Glu Ser His 
465                 470                 475                 480 


Asp Gln Ala Leu Val Gly Asp Lys Ser Leu Ala Phe Trp Leu Met Asp 
                485                 490                 495     


Ala Glu Met Tyr Thr Asn Met Ser Val Leu Thr Pro Phe Thr Pro Val 
            500                 505                 510         


Ile Asp Arg Gly Ile Gln Leu His Lys Met Ile Arg Leu Ile Thr His 
        515                 520                 525             


Gly Leu Gly Gly Glu Gly Tyr Leu Asn Phe Met Gly Asn Glu Phe Gly 
    530                 535                 540                 


His Pro Glu Trp Leu Asp Phe Pro Arg Lys Gly Asn Asn Glu Ser Tyr 
545                 550                 555                 560 


His Tyr Ala Arg Arg Gln Phe His Leu Thr Asp Asp Asp Leu Leu Arg 
                565                 570                 575     


Tyr Lys Phe Leu Asn Asn Phe Asp Arg Asp Met Asn Arg Leu Glu Glu 
            580                 585                 590         


Arg Tyr Gly Trp Leu Ala Ala Pro Gln Ala Tyr Val Ser Glu Lys His 
        595                 600                 605             


Glu Gly Asn Lys Ile Ile Ala Phe Glu Arg Ala Gly Leu Leu Phe Ile 
    610                 615                 620                 


Phe Asn Phe His Pro Ser Lys Ser Tyr Thr Asp Tyr Arg Val Gly Thr 
625                 630                 635                 640 


Ala Leu Pro Gly Lys Phe Lys Ile Val Leu Asp Ser Asp Ala Ala Glu 
                645                 650                 655     


Tyr Gly Gly His Gln Arg Leu Asp His Ser Thr Asp Phe Phe Ser Glu 
            660                 665                 670         


Ala Phe Glu His Asn Gly Arg Pro Tyr Ser Leu Leu Val Tyr Ile Pro 
        675                 680                 685             


Ser Arg Val Ala Leu Ile Leu Gln Asn Val Asp Leu Pro Asn 
    690                 695                 700         


<210>  4365
<211>  1859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBF1__Homo_sapiens__NP_004184

<400>  4365

Met Val Asp Lys Asn Ile Tyr Ile Ile Gln Gly Glu Ile Asn Ile Val 
1               5                   10                  15      


Val Gly Ala Ile Lys Arg Asn Ala Arg Trp Ser Thr His Thr Pro Leu 
            20                  25                  30          


Asp Glu Glu Arg Asp Pro Leu Leu His Ser Phe Gly His Leu Lys Glu 
        35                  40                  45              


Val Leu Asn Ser Ile Thr Glu Leu Ser Glu Ile Glu Pro Asn Val Phe 
    50                  55                  60                  


Leu Arg Pro Phe Leu Glu Val Ile Arg Ser Glu Asp Thr Thr Gly Pro 
65                  70                  75                  80  


Ile Thr Gly Leu Ala Leu Thr Ser Val Asn Lys Phe Leu Ser Tyr Ala 
                85                  90                  95      


Leu Ile Asp Pro Thr His Glu Gly Thr Ala Glu Gly Met Glu Asn Met 
            100                 105                 110         


Ala Asp Ala Val Thr His Ala Arg Phe Val Gly Thr Asp Pro Ala Ser 
        115                 120                 125             


Asp Glu Val Val Leu Met Lys Ile Leu Gln Val Leu Arg Thr Leu Leu 
    130                 135                 140                 


Leu Thr Pro Val Gly Ala His Leu Thr Asn Glu Ser Val Cys Glu Ile 
145                 150                 155                 160 


Met Gln Ser Cys Phe Arg Ile Cys Phe Glu Met Arg Leu Ser Glu Leu 
                165                 170                 175     


Leu Arg Lys Ser Ala Glu His Thr Leu Val Asp Met Val Gln Leu Leu 
            180                 185                 190         


Phe Thr Arg Leu Pro Gln Phe Lys Glu Glu Pro Lys Asn Tyr Val Gly 
        195                 200                 205             


Thr Asn Met Lys Lys Leu Lys Met Arg Ala Gly Gly Met Ser Asp Ser 
    210                 215                 220                 


Ser Lys Trp Lys Lys Gln Lys Arg Ser Pro Arg Pro Pro Arg His Met 
225                 230                 235                 240 


Thr Lys Val Thr Pro Gly Ser Glu Leu Pro Thr Pro Asn Gly Thr Thr 
                245                 250                 255     


Leu Ser Ser Asn Leu Thr Gly Gly Met Pro Phe Ile Asp Val Pro Thr 
            260                 265                 270         


Pro Ile Ser Ser Ala Ser Ser Glu Ala Ala Ser Ala Val Val Ser Pro 
        275                 280                 285             


Ser Thr Asp Ser Gly Leu Glu Phe Ser Ser Gln Thr Thr Ser Lys Glu 
    290                 295                 300                 


Asp Leu Thr Asp Leu Glu Gln Pro Gly Ser Pro Gly Tyr Ser Thr Ala 
305                 310                 315                 320 


Thr Glu Pro Gly Ser Ser Glu Leu Gly Val Pro Glu Gln Pro Asp Leu 
                325                 330                 335     


Gln Glu Gly Thr His Val Glu Lys Ser Gln Ser Ala Ser Val Glu Ser 
            340                 345                 350         


Ile Pro Glu Val Leu Glu Glu Cys Thr Ser Pro Ala Asp His Ser Asp 
        355                 360                 365             


Ser Ala Ser Val His Asp Met Asp Tyr Val Asn Pro Arg Gly Val Arg 
    370                 375                 380                 


Phe Thr Gln Ser Ser Gln Lys Glu Gly Thr Ala Leu Val Pro Tyr Gly 
385                 390                 395                 400 


Leu Pro Cys Ile Arg Glu Leu Phe Arg Phe Leu Ile Ser Leu Thr Asn 
                405                 410                 415     


Pro His Asp Arg His Asn Ser Glu Val Met Ile His Met Gly Leu His 
            420                 425                 430         


Leu Leu Thr Val Ala Leu Glu Ser Ala Pro Val Ala Gln Cys Gln Thr 
        435                 440                 445             


Leu Leu Gly Leu Ile Lys Asp Glu Met Cys Arg His Leu Phe Gln Leu 
    450                 455                 460                 


Leu Ser Ile Glu Arg Leu Asn Leu Tyr Ala Ala Ser Leu Arg Val Cys 
465                 470                 475                 480 


Phe Leu Leu Phe Glu Ser Met Arg Glu His Leu Lys Phe Gln Met Glu 
                485                 490                 495     


Met Tyr Ile Lys Lys Leu Met Glu Ile Ile Thr Val Glu Asn Pro Lys 
            500                 505                 510         


Met Pro Tyr Glu Met Lys Glu Met Ala Leu Glu Ala Ile Val Gln Leu 
        515                 520                 525             


Trp Arg Ile Pro Ser Phe Val Thr Glu Leu Tyr Ile Asn Tyr Asp Cys 
    530                 535                 540                 


Asp Tyr Tyr Cys Ser Asn Leu Phe Glu Glu Leu Thr Lys Leu Leu Ser 
545                 550                 555                 560 


Lys Asn Ala Phe Pro Val Ser Gly Gln Leu Tyr Thr Thr His Leu Leu 
                565                 570                 575     


Ser Leu Asp Ala Leu Leu Thr Val Ile Asp Ser Thr Glu Ala His Cys 
            580                 585                 590         


Gln Ala Lys Val Leu Asn Ser Leu Thr Gln Gln Glu Lys Lys Glu Thr 
        595                 600                 605             


Ala Arg Pro Ser Cys Glu Ile Val Asp Gly Thr Arg Glu Ala Ser Asn 
    610                 615                 620                 


Thr Glu Arg Thr Ala Ser Asp Gly Lys Ala Val Gly Met Ala Ser Asp 
625                 630                 635                 640 


Ile Pro Gly Leu His Leu Pro Gly Gly Gly Arg Leu Pro Pro Glu His 
                645                 650                 655     


Gly Lys Ser Gly Cys Ser Asp Leu Glu Glu Ala Val Asp Ser Gly Ala 
            660                 665                 670         


Asp Lys Lys Phe Ala Arg Lys Pro Pro Arg Phe Ser Cys Leu Leu Pro 
        675                 680                 685             


Asp Pro Arg Glu Leu Ile Glu Ile Lys Asn Lys Lys Lys Leu Leu Ile 
    690                 695                 700                 


Thr Gly Thr Glu Gln Phe Asn Gln Lys Pro Lys Lys Gly Ile Gln Phe 
705                 710                 715                 720 


Leu Gln Glu Lys Gly Leu Leu Thr Ile Pro Met Asp Asn Thr Glu Val 
                725                 730                 735     


Ala Gln Trp Leu Arg Glu Asn Pro Arg Leu Asp Lys Lys Met Ile Gly 
            740                 745                 750         


Glu Phe Val Ser Asp Arg Lys Asn Ile Asp Leu Leu Glu Ser Phe Val 
        755                 760                 765             


Ser Thr Phe Ser Phe Gln Gly Leu Arg Leu Asp Glu Ala Leu Arg Leu 
    770                 775                 780                 


Tyr Leu Glu Ala Phe Arg Leu Pro Gly Glu Ala Pro Val Ile Gln Arg 
785                 790                 795                 800 


Leu Leu Glu Ala Phe Thr Glu Arg Trp Met Asn Cys Asn Gly Ser Pro 
                805                 810                 815     


Phe Ala Asn Ser Asp Ala Cys Phe Ser Leu Ala Tyr Ala Val Ile Met 
            820                 825                 830         


Leu Asn Thr Asp Gln His Asn His Asn Val Arg Lys Gln Asn Ala Pro 
        835                 840                 845             


Met Thr Leu Glu Glu Phe Arg Lys Asn Leu Lys Gly Val Asn Gly Gly 
    850                 855                 860                 


Lys Asp Phe Glu Gln Asp Ile Leu Glu Asp Met Tyr His Ala Ile Lys 
865                 870                 875                 880 


Asn Glu Glu Ile Val Met Pro Glu Glu Gln Thr Gly Leu Val Arg Glu 
                885                 890                 895     


Asn Tyr Val Trp Asn Val Leu Leu His Arg Gly Ala Thr Pro Glu Gly 
            900                 905                 910         


Ile Phe Leu Arg Val Pro Thr Ala Ser Tyr Asp Leu Asp Leu Phe Thr 
        915                 920                 925             


Met Thr Trp Gly Pro Thr Ile Ala Ala Leu Ser Tyr Val Phe Asp Lys 
    930                 935                 940                 


Ser Leu Glu Glu Thr Ile Ile Gln Lys Ala Ile Ser Gly Phe Arg Lys 
945                 950                 955                 960 


Cys Ala Met Ile Ser Ala His Tyr Gly Leu Ser Asp Val Phe Asp Asn 
                965                 970                 975     


Leu Ile Ile Ser Leu Cys Lys Phe Thr Ala Leu Ser Ser Glu Ser Ile 
            980                 985                 990         


Glu Asn Leu Pro Ser Val Phe Gly  Ser Asn Pro Lys Ala  His Ile Ala 
        995                 1000                 1005             


Ala Lys  Thr Val Phe His Leu  Ala His Arg His Gly  Asp Ile Leu 
    1010                 1015                 1020             


Arg Glu  Gly Trp Lys Asn Ile  Met Glu Ala Met Leu  Gln Leu Phe 
    1025                 1030                 1035             


Arg Ala  Gln Leu Leu Pro Lys  Ala Met Ile Glu Val  Glu Asp Phe 
    1040                 1045                 1050             


Val Asp  Pro Asn Gly Lys Ile  Ser Leu Gln Arg Glu  Glu Thr Pro 
    1055                 1060                 1065             


Ser Asn  Arg Gly Glu Ser Thr  Val Leu Ser Phe Val  Ser Trp Leu 
    1070                 1075                 1080             


Thr Leu  Ser Gly Pro Glu Gln  Ser Ser Val Arg Gly  Pro Ser Thr 
    1085                 1090                 1095             


Glu Asn  Gln Glu Ala Lys Arg  Val Ala Leu Glu Cys  Ile Lys Gln 
    1100                 1105                 1110             


Cys Asp  Pro Glu Lys Met Ile  Thr Glu Ser Lys Phe  Leu Gln Leu 
    1115                 1120                 1125             


Glu Ser  Leu Gln Glu Leu Met  Lys Ala Leu Val Ser  Val Thr Pro 
    1130                 1135                 1140             


Asp Glu  Glu Thr Tyr Asp Glu  Glu Asp Ala Ala Phe  Cys Leu Glu 
    1145                 1150                 1155             


Met Leu  Leu Arg Ile Val Leu  Glu Asn Arg Asp Arg  Val Gly Cys 
    1160                 1165                 1170             


Val Trp  Gln Thr Val Arg Asp  His Leu Tyr His Leu  Cys Val Gln 
    1175                 1180                 1185             


Ala Gln  Asp Phe Cys Phe Leu  Val Glu Arg Ala Val  Val Gly Leu 
    1190                 1195                 1200             


Leu Arg  Leu Ala Ile Arg Leu  Leu Arg Arg Glu Glu  Ile Ser Ala 
    1205                 1210                 1215             


Gln Val  Leu Leu Ser Leu Arg  Ile Leu Leu Leu Met  Lys Pro Ser 
    1220                 1225                 1230             


Val Leu  Ser Arg Val Ser His  Gln Val Ala Tyr Gly  Leu His Glu 
    1235                 1240                 1245             


Leu Leu  Lys Thr Asn Ala Ala  Asn Ile His Ser Gly  Asp Asp Trp 
    1250                 1255                 1260             


Ala Thr  Leu Phe Thr Leu Leu  Glu Cys Ile Gly Ser  Gly Val Lys 
    1265                 1270                 1275             


Pro Pro  Ala Ala Leu Gln Ala  Thr Ala Arg Ala Asp  Ala Pro Asp 
    1280                 1285                 1290             


Ala Gly  Ala Gln Ser Asp Ser  Glu Leu Pro Ser Tyr  His Gln Asn 
    1295                 1300                 1305             


Asp Val  Ser Leu Asp Arg Gly  Tyr Thr Ser Asp Ser  Glu Val Tyr 
    1310                 1315                 1320             


Thr Asp  His Gly Arg Pro Gly  Lys Ile His Arg Ser  Ala Thr Asp 
    1325                 1330                 1335             


Ala Asp  Val Val Asn Ser Gly  Trp Leu Val Val Gly  Lys Asp Asp 
    1340                 1345                 1350             


Val Asp  Asn Ser Lys Pro Gly  Pro Ser Arg Pro Gly  Pro Ser Pro 
    1355                 1360                 1365             


Leu Ile  Asn Gln Tyr Ser Leu  Thr Val Gly Leu Asp  Leu Gly Pro 
    1370                 1375                 1380             


His Asp  Thr Lys Ser Leu Leu  Lys Cys Val Glu Ser  Leu Ser Phe 
    1385                 1390                 1395             


Ile Val  Arg Asp Ala Ala His  Ile Thr Pro Asp Asn  Phe Glu Leu 
    1400                 1405                 1410             


Cys Val  Lys Thr Leu Arg Ile  Phe Val Glu Ala Ser  Leu Asn Gly 
    1415                 1420                 1425             


Gly Cys  Lys Ser Gln Glu Lys  Arg Gly Lys Ser His  Lys Tyr Asp 
    1430                 1435                 1440             


Ser Lys  Gly Asn Arg Phe Lys  Lys Lys Ser Lys Glu  Gly Ser Met 
    1445                 1450                 1455             


Leu Arg  Arg Pro Arg Thr Ser  Ser Gln His Ala Ser  Arg Gly Gly 
    1460                 1465                 1470             


Gln Ser  Asp Asp Asp Glu Asp  Glu Gly Val Pro Ala  Ser Tyr His 
    1475                 1480                 1485             


Thr Val  Ser Leu Gln Val Ser  Gln Asp Leu Leu Asp  Leu Met His 
    1490                 1495                 1500             


Thr Leu  His Thr Arg Ala Ala  Ser Ile Tyr Ser Ser  Trp Ala Glu 
    1505                 1510                 1515             


Glu Gln  Arg His Leu Glu Thr  Gly Gly Gln Lys Ile  Glu Ala Asp 
    1520                 1525                 1530             


Ser Arg  Thr Leu Trp Ala His  Cys Trp Cys Pro Leu  Leu Gln Gly 
    1535                 1540                 1545             


Ile Ala  Cys Leu Cys Cys Asp  Ala Arg Arg Gln Val  Arg Met Gln 
    1550                 1555                 1560             


Ala Leu  Thr Tyr Leu Gln Arg  Ala Leu Leu Val His  Asp Leu Gln 
    1565                 1570                 1575             


Lys Leu  Asp Ala Leu Glu Trp  Glu Ser Cys Phe Asn  Lys Val Leu 
    1580                 1585                 1590             


Phe Pro  Leu Leu Thr Lys Leu  Leu Glu Asn Ile Ser  Pro Ala Asp 
    1595                 1600                 1605             


Val Gly  Gly Met Glu Glu Thr  Arg Met Arg Ala Ser  Thr Leu Leu 
    1610                 1615                 1620             


Ser Lys  Val Phe Leu Gln His  Leu Ser Pro Leu Leu  Ser Leu Ser 
    1625                 1630                 1635             


Thr Phe  Ala Ala Leu Trp Leu  Thr Ile Leu Asp Phe  Met Asp Lys 
    1640                 1645                 1650             


Tyr Met  His Ala Gly Ser Ser  Asp Leu Leu Ser Glu  Ala Ile Pro 
    1655                 1660                 1665             


Glu Ser  Leu Lys Asn Met Leu  Leu Val Met Asp Thr  Ala Glu Ile 
    1670                 1675                 1680             


Phe His  Ser Ala Asp Ala Arg  Gly Gly Gly Pro Ser  Ala Leu Trp 
    1685                 1690                 1695             


Glu Ile  Thr Trp Glu Arg Ile  Asp Cys Phe Leu Pro  His Leu Arg 
    1700                 1705                 1710             


Asp Glu  Leu Phe Lys Gln Thr  Val Ile Gln Asp Pro  Met Pro Met 
    1715                 1720                 1725             


Glu Pro  Gln Gly Gln Lys Pro  Leu Ala Ser Ala His  Leu Thr Ser 
    1730                 1735                 1740             


Ala Ala  Gly Asp Thr Arg Thr  Pro Gly His Pro Pro  Pro Pro Glu 
    1745                 1750                 1755             


Ile Pro  Ser Glu Leu Gly Ala  Cys Asp Phe Glu Lys  Pro Glu Ser 
    1760                 1765                 1770             


Pro Arg  Ala Ala Ser Ser Ser  Ser Pro Gly Ser Pro  Val Ala Ser 
    1775                 1780                 1785             


Ser Pro  Ser Arg Leu Ser Pro  Thr Pro Asp Gly Pro  Pro Pro Leu 
    1790                 1795                 1800             


Ala Gln  Pro Pro Leu Ile Leu  Gln Pro Leu Ala Ser  Pro Leu Gln 
    1805                 1810                 1815             


Val Gly  Val Pro Pro Met Thr  Leu Pro Ile Ile Leu  Asn Pro Ala 
    1820                 1825                 1830             


Leu Ile  Glu Ala Thr Ser Pro  Val Pro Leu Leu Ala  Thr Pro Arg 
    1835                 1840                 1845             


Pro Thr  Asp Pro Ile Pro Thr  Ser Glu Val Asn 
    1850                 1855                 


<210>  4366
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBGT1__Homo_sapiens__NP_001269558

<400>  4366

Met His Arg Arg Arg Leu Ala Leu Gly Leu Gly Phe Cys Leu Leu Ala 
1               5                   10                  15      


Gly Thr Ser Leu Ser Val Leu Trp Val Tyr Leu Glu Asn Trp Leu Pro 
            20                  25                  30          


Val Ser Tyr Val Pro Tyr Tyr Leu Pro Cys Pro Glu Ile Phe Asn Met 
        35                  40                  45              


Lys Leu His Tyr Lys Arg Glu Lys Pro Leu Gln Pro Val Val Trp Ser 
    50                  55                  60                  


Gln Tyr Pro Gln Pro Lys Leu Leu Glu His Arg Pro Thr Gln Leu Leu 
65                  70                  75                  80  


Thr Leu Thr Pro Trp Leu Ala Pro Ile Val Ser Glu Gly Thr Phe Asn 
                85                  90                  95      


Pro Glu Leu Leu Gln His Ile Tyr Gln Pro Leu Asn Leu Thr Ile Gly 
            100                 105                 110         


Val Thr Val Phe Ala Val Gly Asn Pro Ser Trp Ser Gln Pro Arg Ser 
        115                 120                 125             


Ser Ser Cys Val Gly Thr Gly Cys Thr Thr Thr Ser Ser Leu Thr Thr 
    130                 135                 140                 


Leu Gln Pro Phe Pro Gly Ser Arg Trp Val Pro Thr Gly Phe Ser Ala 
145                 150                 155                 160 


Pro Ser Pro Ser Arg Val Thr Pro Thr Gly Arg Arg His Pro Cys Ala 
                165                 170                 175     


Gly Trp Arg Pro Ser Ala Ser Thr Leu Leu Arg Gly Leu Thr Gly Arg 
            180                 185                 190         


Trp Thr Thr Ser Ser Ala Leu Met Trp Thr Trp Cys Phe Gly Thr Arg 
        195                 200                 205             


Gly Ala Leu Arg Pro Trp Glu Thr Trp Trp Leu Pro Phe Thr Gln Ala 
    210                 215                 220                 


Thr Thr Pro Phe Pro Ala Ser Ser Ser Pro Met Ser Ala Gly Val Phe 
225                 230                 235                 240 


Pro Leu Pro Leu Trp Gln Thr Ala Lys Gly Thr Ser Ile Met Val Gly 
                245                 250                 255     


Gln Ser Ser Gly Gly Arg Trp Pro Gly Tyr Met Ser Leu Leu Gly Ala 
            260                 265                 270         


Ala Thr Trp Pro Ser Trp Arg Thr Arg Pro Met Ala Ser Trp Leu Pro 
        275                 280                 285             


Gly Gly Arg Lys Ala Thr 
    290                 


<210>  4367
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBX1__Homo_sapiens__NP_001092304

<400>  4367

Met Gln Arg Ala Gly Gly Gly Ser Ala Pro Gly Gly Asn Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Pro Gly Thr Ala Phe Ser Ile Asp Ser Leu Ile Gly 
            20                  25                  30          


Pro Pro Pro Pro Arg Ser Gly His Leu Leu Tyr Thr Gly Tyr Pro Met 
        35                  40                  45              


Phe Met Pro Tyr Arg Pro Leu Val Leu Pro Gln Ala Leu Ala Pro Ala 
    50                  55                  60                  


Pro Leu Pro Ala Gly Leu Pro Pro Leu Ala Pro Leu Ala Ser Phe Ala 
65                  70                  75                  80  


Gly Arg Leu Thr Asn Thr Phe Cys Ala Gly Leu Gly Gln Ala Val Pro 
                85                  90                  95      


Ser Met Val Ala Leu Thr Thr Ala Leu Pro Ser Phe Ala Glu Pro Pro 
            100                 105                 110         


Asp Ala Phe Tyr Gly Pro Gln Glu Leu Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Ala Arg Asn Asn Pro Glu Pro Gly Gly Arg Arg Pro 
    130                 135                 140                 


Glu Gly Gly Leu Glu Ala Asp Glu Leu Leu Pro Ala Arg Glu Lys Val 
145                 150                 155                 160 


Ala Glu Pro Pro Pro Pro Pro Pro Pro His Phe Ser Glu Thr Phe Pro 
                165                 170                 175     


Ser Leu Pro Ala Glu Gly Lys Val Tyr Ser Ser Asp Glu Glu Lys Leu 
            180                 185                 190         


Glu Ala Ser Ala Gly Asp Pro Ala Gly Ser Glu Gln Glu Glu Glu Gly 
        195                 200                 205             


Ser Gly Gly Asp Ser Glu Asp Asp Gly Phe Leu Asp Ser Ser Ala Gly 
    210                 215                 220                 


Gly Pro Gly Ala Leu Leu Gly Pro Lys Pro Lys Leu Lys Gly Ser Leu 
225                 230                 235                 240 


Gly Thr Gly Ala Glu Glu Gly Ala Pro Val Thr Ala Gly Val Thr Ala 
                245                 250                 255     


Pro Gly Gly Lys Ser Arg Arg Arg Arg Thr Ala Phe Thr Ser Glu Gln 
            260                 265                 270         


Leu Leu Glu Leu Glu Lys Glu Phe His Cys Lys Lys Tyr Leu Ser Leu 
        275                 280                 285             


Thr Glu Arg Ser Gln Ile Ala His Ala Leu Lys Leu Ser Glu Val Gln 
    290                 295                 300                 


Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys Trp Lys Arg Ile Lys 
305                 310                 315                 320 


Ala Gly Asn Val Ser Ser Arg Ser Gly Glu Pro Val Arg Asn Pro Lys 
                325                 330                 335     


Ile Val Val Pro Ile Pro Val His Val Asn Arg Phe Ala Val Arg Ser 
            340                 345                 350         


Gln His Gln Gln Met Glu Gln Gly Ala Arg Pro 
        355                 360             


<210>  4368
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GBX2__Homo_sapiens__NP_001476

<400>  4368

Met Ser Ala Ala Phe Pro Pro Ser Leu Met Met Met Gln Arg Pro Leu 
1               5                   10                  15      


Gly Ser Ser Thr Ala Phe Ser Ile Asp Ser Leu Ile Gly Ser Pro Pro 
            20                  25                  30          


Gln Pro Ser Pro Gly His Phe Val Tyr Thr Gly Tyr Pro Met Phe Met 
        35                  40                  45              


Pro Tyr Arg Pro Val Val Leu Pro Pro Pro Pro Pro Pro Pro Pro Ala 
    50                  55                  60                  


Leu Pro Gln Ala Ala Leu Gln Pro Ala Leu Pro Pro Ala His Pro His 
65                  70                  75                  80  


His Gln Ile Pro Ser Leu Pro Thr Gly Phe Cys Ser Ser Leu Ala Gln 
                85                  90                  95      


Gly Met Ala Leu Thr Ser Thr Leu Met Ala Thr Leu Pro Gly Gly Phe 
            100                 105                 110         


Ser Ala Ser Pro Gln His Gln Glu Ala Ala Ala Ala Arg Lys Phe Ala 
        115                 120                 125             


Pro Gln Pro Leu Pro Gly Gly Gly Asn Phe Asp Lys Ala Glu Ala Leu 
    130                 135                 140                 


Gln Ala Asp Ala Glu Asp Gly Lys Gly Phe Leu Ala Lys Glu Gly Ser 
145                 150                 155                 160 


Leu Leu Ala Phe Ser Ala Ala Glu Thr Val Gln Ala Ser Leu Val Gly 
                165                 170                 175     


Ala Val Arg Gly Gln Gly Lys Asp Glu Ser Lys Val Glu Asp Asp Pro 
            180                 185                 190         


Lys Gly Lys Glu Glu Ser Phe Ser Leu Glu Ser Asp Val Asp Tyr Ser 
        195                 200                 205             


Ser Asp Asp Asn Leu Thr Gly Gln Ala Ala His Lys Glu Glu Asp Pro 
    210                 215                 220                 


Gly His Ala Leu Glu Glu Thr Pro Pro Ser Ser Gly Ala Ala Gly Ser 
225                 230                 235                 240 


Thr Thr Ser Thr Gly Lys Asn Arg Arg Arg Arg Thr Ala Phe Thr Ser 
                245                 250                 255     


Glu Gln Leu Leu Glu Leu Glu Lys Glu Phe His Cys Lys Lys Tyr Leu 
            260                 265                 270         


Ser Leu Thr Glu Arg Ser Gln Ile Ala His Ala Leu Lys Leu Ser Glu 
        275                 280                 285             


Val Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys Trp Lys Arg 
    290                 295                 300                 


Val Lys Ala Gly Asn Ala Asn Ser Lys Thr Gly Glu Pro Ser Arg Asn 
305                 310                 315                 320 


Pro Lys Ile Val Val Pro Ile Pro Val His Val Ser Arg Phe Ala Ile 
                325                 330                 335     


Arg Ser Gln His Gln Gln Leu Glu Gln Ala Arg Pro 
            340                 345             


<210>  4369
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCA__Homo_sapiens__NP_036330

<400>  4369

Met Ala Tyr Pro Gly Tyr Gly Gly Gly Phe Gly Asn Phe Ser Ile Gln 
1               5                   10                  15      


Val Pro Gly Met Gln Met Gly Gln Pro Val Pro Glu Thr Gly Pro Ala 
            20                  25                  30          


Ile Leu Leu Asp Gly Tyr Ser Gly Pro Ala Tyr Ser Asp Thr Tyr Ser 
        35                  40                  45              


Ser Ala Gly Asp Ser Val Tyr Thr Tyr Phe Ser Ala Val Ala Gly Gln 
    50                  55                  60                  


Asp Gly Glu Val Asp Ala Glu Glu Leu Gln Arg Cys Leu Thr Gln Ser 
65                  70                  75                  80  


Gly Ile Asn Gly Thr Tyr Ser Pro Phe Ser Leu Glu Thr Cys Arg Ile 
                85                  90                  95      


Met Ile Ala Met Leu Asp Arg Asp His Thr Gly Lys Met Gly Phe Asn 
            100                 105                 110         


Ala Phe Lys Glu Leu Trp Ala Ala Leu Asn Ala Trp Lys Glu Asn Phe 
        115                 120                 125             


Met Thr Val Asp Gln Asp Gly Ser Gly Thr Val Glu His His Glu Leu 
    130                 135                 140                 


Arg Gln Ala Ile Gly Leu Met Gly Tyr Arg Leu Ser Pro Gln Thr Leu 
145                 150                 155                 160 


Thr Thr Ile Val Lys Arg Tyr Ser Lys Asn Gly Arg Ile Phe Phe Asp 
                165                 170                 175     


Asp Tyr Val Ala Cys Cys Val Lys Leu Arg Ala Leu Thr Asp Phe Phe 
            180                 185                 190         


Arg Lys Arg Asp His Leu Gln Gln Gly Ser Ala Asn Phe Ile Tyr Asp 
        195                 200                 205             


Asp Phe Leu Gln Gly Thr Met Ala Ile 
    210                 215         


<210>  4370
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCC1__Homo_sapiens__NP_078799

<400>  4370

Met Glu Lys Phe Gly Met Asn Phe Gly Gly Gly Pro Ser Lys Lys Asp 
1               5                   10                  15      


Leu Leu Glu Thr Ile Glu Thr Gln Lys Lys Gln Leu Leu Gln Tyr Gln 
            20                  25                  30          


Ala Arg Leu Lys Asp Val Val Arg Ala Tyr Lys Ser Leu Leu Lys Glu 
        35                  40                  45              


Lys Glu Ala Leu Glu Ala Ser Ile Lys Val Leu Ser Val Ser His Glu 
    50                  55                  60                  


Ala Asp Val Gly Leu Ala Gly Val Gln Leu Pro Gly Leu Thr Phe Pro 
65                  70                  75                  80  


Asp Ser Val Asp Asp Arg Cys Ser Thr His Ser Glu Asp Ser Thr Gly 
                85                  90                  95      


Thr Ala Thr Ser Leu Asp Thr Ala Ala Ser Leu Thr Ser Thr Lys Gly 
            100                 105                 110         


Glu Phe Gly Val Glu Asp Asp Arg Pro Ala Arg Gly Pro Pro Pro Pro 
        115                 120                 125             


Lys Ser Glu Glu Ala Ser Trp Ser Glu Ser Gly Val Ser Ser Ser Ser 
    130                 135                 140                 


Gly Asp Gly Pro Phe Ala Gly Gly Glu Val Asp Lys Arg Leu His Gln 
145                 150                 155                 160 


Leu Lys Thr Gln Leu Ala Thr Leu Thr Ser Ser Leu Ala Thr Val Thr 
                165                 170                 175     


Gln Glu Lys Ser Arg Met Glu Ala Ser Tyr Leu Ala Asp Lys Lys Lys 
            180                 185                 190         


Met Lys Gln Asp Leu Glu Asp Ala Ser Asn Lys Ala Glu Glu Glu Arg 
        195                 200                 205             


Ala Arg Leu Glu Gly Glu Leu Lys Gly Leu Gln Glu Gln Ile Ala Glu 
    210                 215                 220                 


Thr Lys Ala Arg Leu Ile Thr Gln Gln His Asp Arg Ala Gln Glu Gln 
225                 230                 235                 240 


Ser Asp His Ala Leu Met Leu Arg Glu Leu Gln Lys Leu Leu Gln Glu 
                245                 250                 255     


Glu Arg Thr Gln Arg Gln Asp Leu Glu Leu Arg Leu Glu Glu Thr Arg 
            260                 265                 270         


Glu Ala Leu Ala Gly Arg Ala Tyr Ala Ala Glu Gln Met Glu Gly Phe 
        275                 280                 285             


Glu Leu Gln Thr Lys Gln Leu Thr Arg Glu Val Glu Glu Leu Lys Ser 
    290                 295                 300                 


Glu Leu Gln Ala Ile Arg Asp Glu Lys Asn Gln Pro Asp Pro Arg Leu 
305                 310                 315                 320 


Gln Glu Leu Gln Glu Glu Ala Ala Arg Leu Lys Ser His Phe Gln Ala 
                325                 330                 335     


Gln Leu Gln Gln Glu Met Arg Lys Thr Ala Leu Ala Glu Asp Gln Leu 
            340                 345                 350         


Arg Gln Gln Ser Gln Val Glu Glu Gln Arg Val Ala Ala Leu Glu Asn 
        355                 360                 365             


Gln Ile Ser Glu Val Ser Glu Leu Leu Gly Thr Tyr Glu Lys Ala Lys 
    370                 375                 380                 


Gln Lys Asp Gln Leu Ala Ile Gln Lys Leu Lys Glu Arg Ile Leu Gln 
385                 390                 395                 400 


Leu Asp Leu Glu Asn Lys Thr Leu Ala Leu Ala Ala Ser Ser Arg Ser 
                405                 410                 415     


Pro Leu Asp Ser His Gly Glu Glu Ser Ser Leu Asp Val Asn Val Leu 
            420                 425                 430         


Lys Asp Lys Met Glu Lys Leu Lys Arg Leu Leu Gln Val Ala Ala Arg 
        435                 440                 445             


Lys Ser Gln Val Thr Leu Asp Val Glu Lys Leu Cys Asp Leu Glu Ile 
    450                 455                 460                 


Met Pro Ser Ser Glu Ala Ala Asp Gly Glu Lys Ala Thr Ala Leu Tyr 
465                 470                 475                 480 


Tyr Gln Gln Glu Leu Lys Gln Leu Lys Glu Glu Phe Glu Arg Tyr Lys 
                485                 490                 495     


Met Arg Ala Gln Val Val Leu Lys Ser Lys Asn Thr Lys Asp Gly Asn 
            500                 505                 510         


Leu Gly Lys Glu Leu Glu Ala Ala Gln Glu Gln Leu Ala Glu Leu Lys 
        515                 520                 525             


Glu Lys Tyr Ile Ser Leu Arg Leu Ser Cys Glu Glu Leu Glu His Gln 
    530                 535                 540                 


His Gln Gln Glu Ala Asp Asp Trp Lys Gln Glu Leu Ala Arg Leu Gln 
545                 550                 555                 560 


Gln Leu His Arg Gln Glu Leu Glu Arg Cys Gln Leu Asp Phe Arg Asp 
                565                 570                 575     


Arg Thr Leu Lys Leu Glu Glu Glu Leu His Lys Gln Arg Asp Arg Ala 
            580                 585                 590         


Leu Ala Val Leu Thr Glu Lys Asp Leu Glu Leu Glu Gln Leu Arg Ser 
        595                 600                 605             


Val Ala Leu Ala Ser Gly Leu Pro Gly Arg Arg Ser Pro Val Gly Gly 
    610                 615                 620                 


Gly Gly Pro Gly Asp Pro Ala Asp Thr Ser Ser Ser Asp Ser Leu Thr 
625                 630                 635                 640 


Gln Ala Leu Gln Leu Ala Ala Ala Asn Glu Pro Thr Phe Phe Leu Tyr 
                645                 650                 655     


Ala Glu Gln Leu Ala Arg Lys Glu Val Glu Ile Thr Ser Leu Arg Lys 
            660                 665                 670         


Gln Lys His Arg Leu Glu Val Glu Val His Gln Leu Gln Asp Arg Leu 
        675                 680                 685             


Leu Glu Glu Gly Glu Arg His Arg Glu Glu Val Ala Ala Leu Gln Ser 
    690                 695                 700                 


His Ile Glu Lys Asn Ile Arg Asp Gln Ser Arg Glu Gly Ala Asn Leu 
705                 710                 715                 720 


Glu Tyr Leu Lys Asn Ile Ile Tyr Arg Phe Leu Thr Leu Pro Asp Ser 
                725                 730                 735     


Leu Gly Arg Gln Gln Thr Leu Thr Ala Ile Leu Thr Ile Leu His Phe 
            740                 745                 750         


Ser Pro Glu Glu Lys Gln Val Ile Met Arg Leu Pro Thr Ser Ala Ser 
        755                 760                 765             


Trp Trp Pro Ser Gly Lys Arg 
    770                 775 


<210>  4371
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCDH__Homo_sapiens__NP_000150

<400>  4371

Met Ala Leu Arg Gly Val Ser Val Arg Leu Leu Ser Arg Gly Pro Gly 
1               5                   10                  15      


Leu His Val Leu Arg Thr Trp Val Ser Ser Ala Ala Gln Thr Glu Lys 
            20                  25                  30          


Gly Gly Arg Thr Gln Ser Gln Leu Ala Lys Ser Ser Arg Pro Glu Phe 
        35                  40                  45              


Asp Trp Gln Asp Pro Leu Val Leu Glu Glu Gln Leu Thr Thr Asp Glu 
    50                  55                  60                  


Ile Leu Ile Arg Asp Thr Phe Arg Thr Tyr Cys Gln Glu Arg Leu Met 
65                  70                  75                  80  


Pro Arg Ile Leu Leu Ala Asn Arg Asn Glu Val Phe His Arg Glu Ile 
                85                  90                  95      


Ile Ser Glu Met Gly Glu Leu Gly Val Leu Gly Pro Thr Ile Lys Gly 
            100                 105                 110         


Tyr Gly Cys Ala Gly Val Ser Ser Val Ala Tyr Gly Leu Leu Ala Arg 
        115                 120                 125             


Glu Leu Glu Arg Val Asp Ser Gly Tyr Arg Ser Ala Met Ser Val Gln 
    130                 135                 140                 


Ser Ser Leu Val Met His Pro Ile Tyr Ala Tyr Gly Ser Glu Glu Gln 
145                 150                 155                 160 


Arg Gln Lys Tyr Leu Pro Gln Leu Ala Lys Gly Glu Leu Leu Gly Cys 
                165                 170                 175     


Phe Gly Leu Thr Glu Pro Asn Ser Gly Ser Asp Pro Ser Ser Met Glu 
            180                 185                 190         


Thr Arg Ala His Tyr Asn Ser Ser Asn Lys Ser Tyr Thr Leu Asn Gly 
        195                 200                 205             


Thr Lys Thr Trp Ile Thr Asn Ser Pro Met Ala Asp Leu Phe Val Val 
    210                 215                 220                 


Trp Ala Arg Cys Glu Asp Gly Cys Ile Arg Gly Phe Leu Leu Glu Lys 
225                 230                 235                 240 


Gly Met Arg Gly Leu Ser Ala Pro Arg Ile Gln Gly Lys Phe Ser Leu 
                245                 250                 255     


Arg Ala Ser Ala Thr Gly Met Ile Ile Met Asp Gly Val Glu Val Pro 
            260                 265                 270         


Glu Glu Asn Val Leu Pro Gly Ala Ser Ser Leu Gly Gly Pro Phe Gly 
        275                 280                 285             


Cys Leu Asn Asn Ala Arg Tyr Gly Ile Ala Trp Gly Val Leu Gly Ala 
    290                 295                 300                 


Ser Glu Phe Cys Leu His Thr Ala Arg Gln Tyr Ala Leu Asp Arg Met 
305                 310                 315                 320 


Gln Phe Gly Val Pro Leu Ala Arg Asn Gln Leu Ile Gln Lys Lys Leu 
                325                 330                 335     


Ala Asp Met Leu Thr Glu Ile Thr Leu Gly Leu His Ala Cys Leu Gln 
            340                 345                 350         


Leu Gly Arg Leu Lys Asp Gln Asp Lys Ala Ala Pro Glu Met Val Ser 
        355                 360                 365             


Leu Leu Lys Arg Asn Asn Cys Gly Lys Ala Leu Asp Ile Ala Arg Gln 
    370                 375                 380                 


Ala Arg Asp Met Leu Gly Gly Asn Gly Ile Ser Asp Glu Tyr His Val 
385                 390                 395                 400 


Ile Arg His Ala Met Asn Leu Glu Ala Val Asn Thr Tyr Glu Gly Thr 
                405                 410                 415     


His Asp Ile His Ala Leu Ile Leu Gly Arg Ala Ile Thr Gly Ile Gln 
            420                 425                 430         


Ala Phe Thr Ala Ser Lys 
        435             


<210>  4372
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCFC2__Homo_sapiens__NP_003194

<400>  4372

Met Ala His Arg Pro Lys Arg Thr Phe Arg Gln Arg Ala Ala Asp Ser 
1               5                   10                  15      


Ser Asp Ser Asp Gly Ala Glu Glu Ser Pro Ala Glu Pro Gly Ala Pro 
            20                  25                  30          


Arg Glu Leu Pro Val Pro Gly Ser Ala Glu Glu Glu Pro Pro Ser Gly 
        35                  40                  45              


Gly Gly Arg Ala Gln Val Ala Gly Leu Pro His Arg Val Arg Gly Pro 
    50                  55                  60                  


Arg Gly Arg Gly Arg Val Trp Ala Ser Ser Arg Arg Ala Thr Lys Ala 
65                  70                  75                  80  


Ala Pro Arg Ala Asp Glu Gly Ser Glu Ser Arg Thr Leu Asp Val Ser 
                85                  90                  95      


Thr Asp Glu Glu Asp Lys Ile His His Ser Ser Glu Ser Lys Asp Asp 
            100                 105                 110         


Gln Gly Leu Ser Ser Asp Ser Ser Ser Ser Leu Gly Glu Lys Glu Leu 
        115                 120                 125             


Ser Ser Thr Val Lys Ile Pro Asp Ala Ala Phe Ile Gln Ala Ala Arg 
    130                 135                 140                 


Arg Lys Arg Glu Leu Ala Arg Ala Gln Asp Asp Tyr Ile Ser Leu Asp 
145                 150                 155                 160 


Val Gln His Thr Ser Ser Ile Ser Gly Met Lys Arg Glu Ser Glu Asp 
                165                 170                 175     


Asp Pro Glu Ser Glu Pro Asp Asp His Glu Lys Arg Ile Pro Phe Thr 
            180                 185                 190         


Leu Arg Pro Gln Thr Leu Arg Gln Arg Met Ala Glu Glu Ser Ile Ser 
        195                 200                 205             


Arg Asn Glu Glu Thr Ser Glu Glu Ser Gln Glu Asp Glu Lys Gln Asp 
    210                 215                 220                 


Thr Trp Glu Gln Gln Gln Met Arg Lys Ala Val Lys Ile Ile Glu Glu 
225                 230                 235                 240 


Arg Asp Ile Asp Leu Ser Cys Gly Asn Gly Ser Ser Lys Val Lys Lys 
                245                 250                 255     


Phe Asp Thr Ser Ile Ser Phe Pro Pro Val Asn Leu Glu Ile Ile Lys 
            260                 265                 270         


Lys Gln Leu Asn Thr Arg Leu Thr Leu Leu Gln Glu Thr His Arg Ser 
        275                 280                 285             


His Leu Arg Glu Tyr Glu Lys Tyr Val Gln Asp Val Lys Ser Ser Lys 
    290                 295                 300                 


Ser Thr Ile Gln Asn Leu Glu Ser Ser Ser Asn Gln Ala Leu Asn Cys 
305                 310                 315                 320 


Lys Phe Tyr Lys Ser Met Lys Ile Tyr Val Glu Asn Leu Ile Asp Cys 
                325                 330                 335     


Leu Asn Glu Lys Ile Ile Asn Ile Gln Glu Ile Glu Ser Ser Met His 
            340                 345                 350         


Ala Leu Leu Leu Lys Gln Ala Met Thr Phe Met Lys Arg Arg Gln Asp 
        355                 360                 365             


Glu Leu Lys His Glu Ser Thr Tyr Leu Gln Gln Leu Ser Arg Lys Asp 
    370                 375                 380                 


Glu Thr Ser Thr Ser Gly Asn Phe Ser Val Asp Glu Lys Thr Gln Trp 
385                 390                 395                 400 


Ile Leu Glu Glu Ile Glu Ser Arg Arg Thr Lys Arg Arg Gln Ala Arg 
                405                 410                 415     


Val Leu Ser Gly Asn Cys Asn His Gln Glu Gly Thr Ser Ser Asp Asp 
            420                 425                 430         


Glu Leu Pro Ser Ala Glu Met Ile Asp Phe Gln Lys Ser Gln Gly Asp 
        435                 440                 445             


Ile Leu Gln Lys Gln Lys Lys Val Phe Glu Glu Val Gln Asp Asp Phe 
    450                 455                 460                 


Cys Asn Ile Gln Asn Ile Leu Leu Lys Phe Gln Gln Trp Arg Glu Lys 
465                 470                 475                 480 


Phe Pro Asp Ser Tyr Tyr Glu Ala Phe Ile Ser Leu Cys Ile Pro Lys 
                485                 490                 495     


Leu Leu Asn Pro Leu Ile Arg Val Gln Leu Ile Asp Trp Asn Pro Leu 
            500                 505                 510         


Lys Leu Glu Ser Thr Gly Leu Lys Glu Met Pro Trp Phe Lys Ser Val 
        515                 520                 525             


Glu Glu Phe Met Asp Ser Ser Val Glu Asp Ser Lys Lys Glu Ser Ser 
    530                 535                 540                 


Ser Asp Lys Lys Val Leu Ser Ala Ile Ile Asn Lys Thr Ile Ile Pro 
545                 550                 555                 560 


Arg Leu Thr Asp Phe Val Glu Phe Leu Trp Asp Pro Leu Ser Thr Ser 
                565                 570                 575     


Gln Thr Thr Ser Leu Ile Thr His Cys Arg Val Ile Leu Glu Glu His 
            580                 585                 590         


Ser Thr Cys Glu Asn Glu Val Ser Lys Ser Arg Gln Asp Leu Leu Lys 
        595                 600                 605             


Ser Ile Val Ser Arg Met Lys Lys Ala Val Glu Asp Asp Val Phe Ile 
    610                 615                 620                 


Pro Leu Tyr Pro Lys Ser Ala Val Glu Asn Lys Thr Ser Pro His Ser 
625                 630                 635                 640 


Lys Phe Gln Glu Arg Gln Phe Trp Ser Gly Leu Lys Leu Phe Arg Asn 
                645                 650                 655     


Ile Leu Leu Trp Asn Gly Leu Leu Thr Asp Asp Thr Leu Gln Glu Leu 
            660                 665                 670         


Gly Leu Gly Lys Leu Leu Asn Arg Tyr Leu Ile Ile Ala Leu Leu Asn 
        675                 680                 685             


Ala Thr Pro Gly Pro Asp Val Val Lys Lys Cys Asn Gln Val Ala Ala 
    690                 695                 700                 


Cys Leu Pro Glu Lys Trp Phe Glu Asn Ser Ala Met Arg Thr Ser Ile 
705                 710                 715                 720 


Pro Gln Leu Glu Asn Phe Ile Gln Phe Leu Leu Gln Ser Ala His Lys 
                725                 730                 735     


Leu Ser Arg Ser Glu Phe Arg Asp Glu Val Glu Glu Ile Ile Leu Ile 
            740                 745                 750         


Leu Val Lys Ile Lys Ala Leu Asn Gln Ala Glu Ser Phe Ile Gly Glu 
        755                 760                 765             


His His Leu Asp His Leu Lys Ser Leu Ile Lys Glu Asp 
    770                 775                 780     


<210>  4373
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCG__Homo_sapiens__NP_002045

<400>  4373

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  4374
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCGR__Homo_sapiens__XP_006722340

<400>  4374

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      


Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             


Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 


Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     


His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         


Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             


Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Ala Val Ala Gly Cys 
    210                 215                 220                 


Arg Val Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys 
225                 230                 235                 240 


Trp Leu Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala 
                245                 250                 255     


Thr Leu Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp 
            260                 265                 270         


Gly Ala Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu 
        275                 280                 285             


Phe Glu Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp 
    290                 295                 300                 


Trp Ile Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe 
305                 310                 315                 320 


Ile Phe Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg 
                325                 330                 335     


Gln Met His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu 
            340                 345                 350         


Thr Leu Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val 
        355                 360                 365             


Thr Asp Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe 
    370                 375                 380                 


Asp Leu Phe Leu Ser Ser Phe Gln Gly Leu Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Lys Glu Val Gln Ser Glu Leu Arg Arg Arg Trp His 
                405                 410                 415     


Arg Trp Arg Leu Gly Lys Val Leu Trp Glu Glu Arg Asn Thr Ser Asn 
            420                 425                 430         


His Arg Ala Ser Ser Ser Pro Gly His Gly Pro Pro Ser Lys Glu Leu 
        435                 440                 445             


Gln Phe Gly Arg Gly Gly Gly Ser Gln Asp Ser Ser Ala Glu Thr Pro 
    450                 455                 460                 


Leu Ala Gly Gly Leu Pro Arg Leu Ala Glu Ser Pro Phe 
465                 470                 475         


<210>  4375
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCH1__Homo_sapiens__NP_001019195

<400>  4375

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr His Met Cys Met Val Met Arg Gly Val Gln Lys Met Asn Ser Lys 
    210                 215                 220                 


Thr Val Thr Ser Thr Met Leu Gly Val Phe Arg Glu Asp Pro Lys Thr 
225                 230                 235                 240 


Arg Glu Glu Phe Leu Thr Leu Ile Arg Ser 
                245                 250 


<210>  4376
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCHFR__Homo_sapiens__NP_005249

<400>  4376

Met Pro Tyr Leu Leu Ile Ser Thr Gln Ile Arg Met Glu Val Gly Pro 
1               5                   10                  15      


Thr Met Val Gly Asp Glu Gln Ser Asp Pro Glu Leu Met Gln His Leu 
            20                  25                  30          


Gly Ala Ser Lys Arg Arg Ala Leu Gly Asn Asn Phe Tyr Glu Tyr Tyr 
        35                  40                  45              


Val Asp Asp Pro Pro Arg Ile Val Leu Asp Lys Leu Glu Arg Arg Gly 
    50                  55                  60                  


Phe Arg Val Leu Ser Met Thr Gly Val Gly Gln Thr Leu Val Trp Cys 
65                  70                  75                  80  


Leu His Lys Glu 
                


<210>  4377
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GC__Homo_sapiens__NP_000574

<400>  4377

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210>  4378
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCK__Homo_sapiens__NP_000153

<400>  4378

Met Leu Asp Asp Arg Ala Arg Met Glu Ala Ala Lys Lys Glu Lys Val 
1               5                   10                  15      


Glu Gln Ile Leu Ala Glu Phe Gln Leu Gln Glu Glu Asp Leu Lys Lys 
            20                  25                  30          


Val Met Arg Arg Met Gln Lys Glu Met Asp Arg Gly Leu Arg Leu Glu 
        35                  40                  45              


Thr His Glu Glu Ala Ser Val Lys Met Leu Pro Thr Tyr Val Arg Ser 
    50                  55                  60                  


Thr Pro Glu Gly Ser Glu Val Gly Asp Phe Leu Ser Leu Asp Leu Gly 
65                  70                  75                  80  


Gly Thr Asn Phe Arg Val Met Leu Val Lys Val Gly Glu Gly Glu Glu 
                85                  90                  95      


Gly Gln Trp Ser Val Lys Thr Lys His Gln Met Tyr Ser Ile Pro Glu 
            100                 105                 110         


Asp Ala Met Thr Gly Thr Ala Glu Met Leu Phe Asp Tyr Ile Ser Glu 
        115                 120                 125             


Cys Ile Ser Asp Phe Leu Asp Lys His Gln Met Lys His Lys Lys Leu 
    130                 135                 140                 


Pro Leu Gly Phe Thr Phe Ser Phe Pro Val Arg His Glu Asp Ile Asp 
145                 150                 155                 160 


Lys Gly Ile Leu Leu Asn Trp Thr Lys Gly Phe Lys Ala Ser Gly Ala 
                165                 170                 175     


Glu Gly Asn Asn Val Val Gly Leu Leu Arg Asp Ala Ile Lys Arg Arg 
            180                 185                 190         


Gly Asp Phe Glu Met Asp Val Val Ala Met Val Asn Asp Thr Val Ala 
        195                 200                 205             


Thr Met Ile Ser Cys Tyr Tyr Glu Asp His Gln Cys Glu Val Gly Met 
    210                 215                 220                 


Ile Val Gly Thr Gly Cys Asn Ala Cys Tyr Met Glu Glu Met Gln Asn 
225                 230                 235                 240 


Val Glu Leu Val Glu Gly Asp Glu Gly Arg Met Cys Val Asn Thr Glu 
                245                 250                 255     


Trp Gly Ala Phe Gly Asp Ser Gly Glu Leu Asp Glu Phe Leu Leu Glu 
            260                 265                 270         


Tyr Asp Arg Leu Val Asp Glu Ser Ser Ala Asn Pro Gly Gln Gln Leu 
        275                 280                 285             


Tyr Glu Lys Leu Ile Gly Gly Lys Tyr Met Gly Glu Leu Val Arg Leu 
    290                 295                 300                 


Val Leu Leu Arg Leu Val Asp Glu Asn Leu Leu Phe His Gly Glu Ala 
305                 310                 315                 320 


Ser Glu Gln Leu Arg Thr Arg Gly Ala Phe Glu Thr Arg Phe Val Ser 
                325                 330                 335     


Gln Val Glu Ser Asp Thr Gly Asp Arg Lys Gln Ile Tyr Asn Ile Leu 
            340                 345                 350         


Ser Thr Leu Gly Leu Arg Pro Ser Thr Thr Asp Cys Asp Ile Val Arg 
        355                 360                 365             


Arg Ala Cys Glu Ser Val Ser Thr Arg Ala Ala His Met Cys Ser Ala 
    370                 375                 380                 


Gly Leu Ala Gly Val Ile Asn Arg Met Arg Glu Ser Arg Ser Glu Asp 
385                 390                 395                 400 


Val Met Arg Ile Thr Val Gly Val Asp Gly Ser Val Tyr Lys Leu His 
                405                 410                 415     


Pro Ser Phe Lys Glu Arg Phe His Ala Ser Val Arg Arg Leu Thr Pro 
            420                 425                 430         


Ser Cys Glu Ile Thr Phe Ile Glu Ser Glu Glu Gly Ser Gly Arg Gly 
        435                 440                 445             


Ala Ala Leu Val Ser Ala Val Ala Cys Lys Lys Ala Cys Met Leu Gly 
    450                 455                 460                 


Gln 
465 


<210>  4379
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCKR__Homo_sapiens__NP_001477

<400>  4379

Met Pro Gly Thr Lys Arg Phe Gln His Val Ile Glu Thr Pro Glu Pro 
1               5                   10                  15      


Gly Lys Trp Glu Leu Ser Gly Tyr Glu Ala Ala Val Pro Ile Thr Glu 
            20                  25                  30          


Lys Ser Asn Pro Leu Thr Gln Asp Leu Asp Lys Ala Asp Ala Glu Asn 
        35                  40                  45              


Ile Val Arg Leu Leu Gly Gln Cys Asp Ala Glu Ile Phe Gln Glu Glu 
    50                  55                  60                  


Gly Gln Ala Leu Ser Thr Tyr Gln Arg Leu Tyr Ser Glu Ser Ile Leu 
65                  70                  75                  80  


Thr Thr Met Val Gln Val Ala Gly Lys Val Gln Glu Val Leu Lys Glu 
                85                  90                  95      


Pro Asp Gly Gly Leu Val Val Leu Ser Gly Gly Gly Thr Ser Gly Arg 
            100                 105                 110         


Met Ala Phe Leu Met Ser Val Ser Phe Asn Gln Leu Met Lys Gly Leu 
        115                 120                 125             


Gly Gln Lys Pro Leu Tyr Thr Tyr Leu Ile Ala Gly Gly Asp Arg Ser 
    130                 135                 140                 


Val Val Ala Ser Arg Glu Gly Thr Glu Asp Ser Ala Leu His Gly Ile 
145                 150                 155                 160 


Glu Glu Leu Lys Lys Val Ala Ala Gly Lys Lys Arg Val Ile Val Ile 
                165                 170                 175     


Gly Ile Ser Val Gly Leu Ser Ala Pro Phe Val Ala Gly Gln Met Asp 
            180                 185                 190         


Cys Cys Met Asn Asn Thr Ala Val Phe Leu Pro Val Leu Val Gly Phe 
        195                 200                 205             


Asn Pro Val Ser Met Ala Arg Asn Asp Pro Ile Glu Asp Trp Ser Ser 
    210                 215                 220                 


Thr Phe Arg Gln Val Ala Glu Arg Met Gln Lys Met Gln Glu Lys Gln 
225                 230                 235                 240 


Lys Ala Phe Val Leu Asn Pro Ala Ile Gly Pro Glu Gly Leu Ser Gly 
                245                 250                 255     


Ser Ser Arg Met Lys Gly Gly Ser Ala Thr Lys Ile Leu Leu Glu Thr 
            260                 265                 270         


Leu Leu Leu Ala Ala His Lys Thr Val Asp Gln Gly Ile Ala Ala Ser 
        275                 280                 285             


Gln Arg Cys Leu Leu Glu Ile Leu Arg Thr Phe Glu Arg Ala His Gln 
    290                 295                 300                 


Val Thr Tyr Ser Gln Ser Pro Lys Ile Ala Thr Leu Met Lys Ser Val 
305                 310                 315                 320 


Ser Thr Ser Leu Glu Lys Lys Gly His Val Tyr Leu Val Gly Trp Gln 
                325                 330                 335     


Thr Leu Gly Ile Ile Ala Ile Met Asp Gly Val Glu Cys Ile His Thr 
            340                 345                 350         


Phe Gly Ala Asp Phe Arg Asp Val Arg Gly Phe Leu Ile Gly Asp His 
        355                 360                 365             


Ser Asp Met Phe Asn Gln Lys Ala Glu Leu Thr Asn Gln Gly Pro Gln 
    370                 375                 380                 


Phe Thr Phe Ser Gln Glu Asp Phe Leu Thr Ser Ile Leu Pro Ser Leu 
385                 390                 395                 400 


Thr Glu Ile Asp Thr Val Val Phe Ile Phe Thr Leu Asp Asp Asn Leu 
                405                 410                 415     


Thr Glu Val Gln Thr Ile Val Glu Gln Val Lys Glu Lys Thr Asn His 
            420                 425                 430         


Ile Gln Ala Leu Ala His Ser Thr Val Gly Gln Thr Leu Leu Ile Pro 
        435                 440                 445             


Leu Lys Lys Leu Phe Pro Ser Ile Ile Ser Ile Thr Trp Pro Leu Leu 
    450                 455                 460                 


Phe Phe Glu Tyr Glu Gly Asn Phe Ile Gln Lys Phe Gln Arg Glu Leu 
465                 470                 475                 480 


Ser Thr Lys Trp Val Leu Asn Thr Val Ser Thr Gly Ala His Val Leu 
                485                 490                 495     


Leu Gly Lys Ile Leu Gln Asn His Met Leu Asp Leu Arg Ile Ser Asn 
            500                 505                 510         


Ser Lys Leu Phe Trp Arg Ala Leu Ala Met Leu Gln Arg Phe Ser Gly 
        515                 520                 525             


Gln Ser Lys Ala Arg Cys Ile Glu Ser Leu Leu Arg Ala Ile His Phe 
    530                 535                 540                 


Pro Gln Pro Leu Ser Asp Asp Ile Arg Ala Ala Pro Ile Ser Cys His 
545                 550                 555                 560 


Val Gln Val Ala His Glu Lys Glu Gln Val Ile Pro Ile Ala Leu Leu 
                565                 570                 575     


Ser Leu Leu Phe Arg Cys Ser Ile Thr Glu Ala Gln Ala His Leu Ala 
            580                 585                 590         


Ala Ala Pro Ser Val Cys Glu Ala Val Arg Ser Ala Leu Ala Gly Pro 
        595                 600                 605             


Gly Gln Lys Arg Thr Ala Asp Pro Leu Glu Ile Leu Glu Pro Asp Val 
    610                 615                 620                 


Gln 
625 


<210>  4380
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCLC__Homo_sapiens__NP_001489

<400>  4380

Met Gly Leu Leu Ser Gln Gly Ser Pro Leu Ser Trp Glu Glu Thr Lys 
1               5                   10                  15      


Arg His Ala Asp His Val Arg Arg His Gly Ile Leu Gln Phe Leu His 
            20                  25                  30          


Ile Tyr His Ala Val Lys Asp Arg His Lys Asp Val Leu Lys Trp Gly 
        35                  40                  45              


Asp Glu Val Glu Tyr Met Leu Val Ser Phe Asp His Glu Asn Lys Lys 
    50                  55                  60                  


Val Arg Leu Val Leu Ser Gly Glu Lys Val Leu Glu Thr Leu Gln Glu 
65                  70                  75                  80  


Lys Gly Glu Arg Thr Asn Pro Asn His Pro Thr Leu Trp Arg Pro Glu 
                85                  90                  95      


Tyr Gly Ser Tyr Met Ile Glu Gly Thr Pro Gly Gln Pro Tyr Gly Gly 
            100                 105                 110         


Thr Met Ser Glu Phe Asn Thr Val Glu Ala Asn Met Arg Lys Arg Arg 
        115                 120                 125             


Lys Glu Ala Thr Ser Ile Leu Glu Glu Asn Gln Ala Leu Cys Thr Ile 
    130                 135                 140                 


Thr Ser Phe Pro Arg Leu Gly Cys Pro Gly Phe Thr Leu Pro Glu Val 
145                 150                 155                 160 


Lys Pro Asn Pro Val Glu Gly Gly Ala Ser Lys Ser Leu Phe Phe Pro 
                165                 170                 175     


Asp Glu Ala Ile Asn Lys His Pro Arg Phe Ser Thr Leu Thr Arg Asn 
            180                 185                 190         


Ile Arg His Arg Arg Gly Glu Lys Val Val Ile Asn Val Pro Ile Phe 
        195                 200                 205             


Lys Asp Lys Asn Thr Pro Ser Pro Phe Ile Glu Thr Phe Thr Glu Asp 
    210                 215                 220                 


Asp Glu Ala Ser Arg Ala Ser Lys Pro Asp His Ile Tyr Met Asp Ala 
225                 230                 235                 240 


Met Gly Phe Gly Met Gly Asn Cys Cys Leu Gln Val Thr Phe Gln Ala 
                245                 250                 255     


Cys Ser Ile Ser Glu Ala Arg Tyr Leu Tyr Asp Gln Leu Ala Thr Ile 
            260                 265                 270         


Cys Pro Ile Val Met Ala Leu Ser Ala Ala Ser Pro Phe Tyr Arg Gly 
        275                 280                 285             


Tyr Val Ser Asp Ile Asp Cys Arg Trp Gly Val Ile Ser Ala Ser Val 
    290                 295                 300                 


Asp Asp Arg Thr Arg Glu Glu Arg Gly Leu Glu Pro Leu Lys Asn Asn 
305                 310                 315                 320 


Asn Tyr Arg Ile Ser Lys Ser Arg Tyr Asp Ser Ile Asp Ser Tyr Leu 
                325                 330                 335     


Ser Lys Cys Gly Glu Lys Tyr Asn Asp Ile Asp Leu Thr Ile Asp Lys 
            340                 345                 350         


Glu Ile Tyr Glu Gln Leu Leu Gln Glu Gly Ile Asp His Leu Leu Ala 
        355                 360                 365             


Gln His Val Ala His Leu Phe Ile Arg Asp Pro Leu Thr Leu Phe Glu 
    370                 375                 380                 


Glu Lys Ile His Leu Asp Asp Ala Asn Glu Ser Asp His Phe Glu Asn 
385                 390                 395                 400 


Ile Gln Ser Thr Asn Trp Gln Thr Met Arg Phe Lys Pro Pro Pro Pro 
                405                 410                 415     


Asn Ser Asp Ile Gly Trp Arg Val Glu Phe Arg Pro Met Glu Val Gln 
            420                 425                 430         


Leu Thr Asp Phe Glu Asn Ser Ala Tyr Val Val Phe Val Val Leu Leu 
        435                 440                 445             


Thr Arg Val Ile Leu Ser Tyr Lys Leu Asp Phe Leu Ile Pro Leu Ser 
    450                 455                 460                 


Lys Val Asp Glu Asn Met Lys Val Ala Gln Lys Arg Asp Ala Val Leu 
465                 470                 475                 480 


Gln Gly Met Phe Tyr Phe Arg Lys Asp Ile Cys Lys Gly Gly Asn Ala 
                485                 490                 495     


Val Val Asp Gly Cys Gly Lys Ala Gln Asn Ser Thr Glu Leu Ala Ala 
            500                 505                 510         


Glu Glu Tyr Thr Leu Met Ser Ile Asp Thr Ile Ile Asn Gly Lys Glu 
        515                 520                 525             


Gly Val Phe Pro Gly Leu Ile Pro Ile Leu Asn Ser Tyr Leu Glu Asn 
    530                 535                 540                 


Met Glu Val Asp Val Asp Thr Arg Cys Ser Ile Leu Asn Tyr Leu Lys 
545                 550                 555                 560 


Leu Ile Lys Lys Arg Ala Ser Gly Glu Leu Met Thr Val Ala Arg Trp 
                565                 570                 575     


Met Arg Glu Phe Ile Ala Asn His Pro Asp Tyr Lys Gln Asp Ser Val 
            580                 585                 590         


Ile Thr Asp Glu Met Asn Tyr Ser Leu Ile Leu Lys Cys Asn Gln Ile 
        595                 600                 605             


Ala Asn Glu Leu Cys Glu Cys Pro Glu Leu Leu Gly Ser Ala Phe Arg 
    610                 615                 620                 


Lys Val Lys Tyr Ser Gly Ser Lys Thr Asp Ser Ser Asn 
625                 630                 635         


<210>  4381
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCM1__Homo_sapiens__NP_003634

<400>  4381

Met Glu Pro Asp Asp Phe Asp Ser Glu Asp Lys Glu Ile Leu Ser Trp 
1               5                   10                  15      


Asp Ile Asn Asp Val Lys Leu Pro Gln Asn Val Lys Lys Thr Asp Trp 
            20                  25                  30          


Phe Gln Glu Trp Pro Asp Ser Tyr Ala Lys His Ile Tyr Ser Ser Glu 
        35                  40                  45              


Asp Lys Asn Ala Gln Arg His Leu Ser Ser Trp Ala Met Arg Asn Thr 
    50                  55                  60                  


Asn Asn His Asn Ser Arg Ile Leu Lys Lys Ser Cys Leu Gly Val Val 
65                  70                  75                  80  


Val Cys Gly Arg Asp Cys Leu Ala Glu Glu Gly Arg Lys Ile Tyr Leu 
                85                  90                  95      


Arg Pro Ala Ile Cys Asp Lys Ala Arg Gln Lys Gln Gln Arg Lys Arg 
            100                 105                 110         


Cys Pro Asn Cys Asp Gly Pro Leu Lys Leu Ile Pro Cys Arg Gly His 
        115                 120                 125             


Gly Gly Phe Pro Val Thr Asn Phe Trp Arg His Asp Gly Arg Phe Ile 
    130                 135                 140                 


Phe Phe Gln Ser Lys Gly Glu His Asp His Pro Lys Pro Glu Thr Lys 
145                 150                 155                 160 


Leu Glu Ala Glu Ala Arg Arg Ala Met Lys Lys Val Asn Thr Ala Pro 
                165                 170                 175     


Ser Ser Val Ser Leu Ser Leu Lys Gly Ser Thr Glu Thr Arg Ser Leu 
            180                 185                 190         


Pro Gly Glu Thr Gln Ser Gln Gly Ser Leu Pro Leu Thr Trp Ser Phe 
        195                 200                 205             


Gln Glu Gly Val Gln Leu Pro Gly Ser Tyr Ser Gly His Leu Ile Ala 
    210                 215                 220                 


Asn Thr Pro Gln Gln Asn Ser Leu Asn Asp Cys Phe Ser Phe Ser Lys 
225                 230                 235                 240 


Ser Tyr Gly Leu Gly Gly Ile Thr Asp Leu Thr Asp Gln Thr Ser Thr 
                245                 250                 255     


Val Asp Pro Met Lys Leu Tyr Glu Lys Arg Lys Leu Ser Ser Ser Arg 
            260                 265                 270         


Thr Tyr Ser Ser Gly Asp Leu Leu Pro Pro Ser Ala Ser Gly Val Tyr 
        275                 280                 285             


Ser Asp His Gly Asp Leu Gln Ala Trp Ser Lys Asn Ala Ala Leu Gly 
    290                 295                 300                 


Arg Asn His Leu Ala Asp Asn Cys Tyr Ser Asn Tyr Pro Phe Pro Leu 
305                 310                 315                 320 


Thr Ser Trp Pro Cys Ser Phe Ser Pro Ser Gln Asn Ser Ser Glu Pro 
                325                 330                 335     


Phe Tyr Gln Gln Leu Pro Leu Glu Pro Pro Ala Ala Lys Thr Gly Cys 
            340                 345                 350         


Pro Pro Leu Trp Pro Asn Pro Ala Gly Asn Leu Tyr Glu Glu Lys Val 
        355                 360                 365             


His Val Asp Phe Asn Ser Tyr Val Gln Ser Pro Ala Tyr His Ser Pro 
    370                 375                 380                 


Gln Glu Asp Pro Phe Leu Phe Thr Tyr Ala Ser His Pro His Gln Gln 
385                 390                 395                 400 


Tyr Ser Leu Pro Ser Lys Ser Ser Lys Trp Asp Phe Glu Glu Glu Met 
                405                 410                 415     


Thr Tyr Leu Gly Leu Asp His Cys Asn Asn Asp Met Leu Leu Asn Leu 
            420                 425                 430         


Cys Pro Leu Arg 
        435     


<210>  4382
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCM2__Homo_sapiens__XP_011513293

<400>  4382

Met Pro Ala Ala Ala Val Gln Glu Ala Val Gly Val Cys Ser Tyr Gly 
1               5                   10                  15      


Met Gln Leu Ser Trp Asp Ile Asn Asp Pro Gln Met Pro Gln Glu Leu 
            20                  25                  30          


Ala Leu Phe Asp Gln Phe Arg Glu Trp Pro Asp Gly Tyr Val Arg Phe 
        35                  40                  45              


Ile Tyr Ser Ser Asp Glu Lys Lys Ala Gln Arg His Leu Ser Gly Trp 
    50                  55                  60                  


Ala Met Arg Asn Thr Asn Asn His Asn Gly His Ile Leu Lys Lys Ser 
65                  70                  75                  80  


Cys Leu Gly Val Val Val Cys Thr Gln Ala Cys Thr Leu Pro Asp Gly 
                85                  90                  95      


Ser Arg Leu Gln Leu Arg Pro Ala Ile Cys Asp Lys Ala Arg Leu Lys 
            100                 105                 110         


Gln Gln Lys Lys Ala Cys Pro Asn Cys His Ser Ala Leu Glu Leu Ile 
        115                 120                 125             


Pro Cys Arg Gly His Ser Gly Tyr Pro Val Thr Asn Phe Trp Arg Leu 
    130                 135                 140                 


Asp Gly Asn Ala Ile Phe Phe Gln Ala Lys Gly Val His Asp His Pro 
145                 150                 155                 160 


Arg Pro Glu Ser Lys Ser Glu Thr Glu Ala Arg Arg Ser Ala Ile Lys 
                165                 170                 175     


Arg Gln Met Ala Ser Phe Tyr Gln Pro Gln Lys Lys Arg Ile Arg Glu 
            180                 185                 190         


Ser Glu Ala Glu Glu Asn Gln Asp Ser Ser Gly His Phe Ser Asn Ile 
        195                 200                 205             


Pro Pro Leu Glu Asn Pro Glu Asp Phe Asp Ile Val Thr Glu Thr Ser 
    210                 215                 220                 


Phe Pro Ile Pro Gly Gln Pro Cys Pro Ser Phe Pro Lys Ser Asp Val 
225                 230                 235                 240 


Tyr Lys Ala Thr Cys Asp Leu Ala Thr Phe Gln Gly Asp Lys Met Pro 
                245                 250                 255     


Pro Phe Gln Lys Tyr Ser Ser Pro Arg Ile Tyr Leu Pro Arg Pro Pro 
            260                 265                 270         


Cys Ser Tyr Glu Leu Ala Asn Pro Gly Tyr Thr Asn Ser Ser Pro Tyr 
        275                 280                 285             


Pro Thr Leu Tyr Lys Asp Ser Thr Ser Ile Pro Asn Asp Thr Asp Trp 
    290                 295                 300                 


Val His Leu Asn Thr Leu Gln Cys Asn Val Asn Ser Tyr Ser Ser Tyr 
305                 310                 315                 320 


Glu Arg Ser Phe Asp Phe Thr Asn Lys Gln His Gly Trp Lys Pro Ala 
                325                 330                 335     


Leu Gly Lys Pro Ser Leu Val Glu Arg Thr Asn His Gly Gln Phe Gln 
            340                 345                 350         


Ala Met Ala Thr Arg Pro Tyr Tyr Asn Pro Glu Leu Pro Cys Arg Tyr 
        355                 360                 365             


Leu Thr Thr Pro Pro Pro Gly Ala Pro Ala Leu Gln Thr Val Ile Thr 
    370                 375                 380                 


Thr Thr Thr Lys Val Ser Tyr Gln Ala Tyr Gln Pro Pro Ala Met Lys 
385                 390                 395                 400 


Tyr Ser Asp Ser Val Arg Glu Val Lys Ser Leu Ser Ser Cys Asn Tyr 
                405                 410                 415     


Ala Pro Glu Asp Thr Gly Met Ser Val Tyr Pro Glu Pro Trp Gly Pro 
            420                 425                 430         


Pro Val Thr Val Thr Arg Ala Ala Ser Pro Ser Gly Pro Pro Pro Met 
        435                 440                 445             


Lys Ile Ala Gly Asp Cys Arg Ala Ile Arg Pro Thr Val Ala Ile Pro 
    450                 455                 460                 


His Glu Pro Val Ser Ser Arg Thr Asp Glu Ala Glu Thr Trp Asp Val 
465                 470                 475                 480 


Cys Leu Ser Gly Leu Gly Ser Ala Val Ser Tyr Ser Asp Arg Val Gly 
                485                 490                 495     


Pro Phe Phe Thr Tyr Asn Asn Glu Asp Phe 
            500                 505     


<210>  4383
<211>  2671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN1L1__Homo_sapiens__NP_006827

<400>  4383

Met Ala Ala Asp Thr Gln Val Ser Glu Thr Leu Lys Arg Phe Ala Gly 
1               5                   10                  15      


Lys Val Thr Thr Ala Ser Val Lys Glu Arg Arg Glu Ile Leu Ser Glu 
            20                  25                  30          


Leu Gly Lys Cys Val Ala Gly Lys Asp Leu Pro Glu Gly Ala Val Lys 
        35                  40                  45              


Gly Leu Cys Lys Leu Phe Cys Leu Thr Leu His Arg Tyr Arg Asp Ala 
    50                  55                  60                  


Ala Ser Arg Arg Ala Leu Gln Ala Ala Ile Gln Gln Leu Ala Glu Ala 
65                  70                  75                  80  


Gln Pro Glu Ala Thr Ala Lys Asn Leu Leu His Ser Leu Gln Ser Ser 
                85                  90                  95      


Gly Ile Gly Ser Lys Ala Gly Val Pro Ser Lys Ser Ser Gly Ser Ala 
            100                 105                 110         


Ala Leu Leu Ala Leu Thr Trp Thr Cys Leu Leu Val Arg Ile Val Phe 
        115                 120                 125             


Pro Ser Arg Ala Lys Arg Gln Gly Asp Ile Trp Asn Lys Leu Val Glu 
    130                 135                 140                 


Val Gln Cys Leu Leu Leu Leu Glu Val Leu Gly Gly Ser His Lys His 
145                 150                 155                 160 


Ala Val Asp Gly Ala Val Lys Lys Leu Thr Lys Leu Trp Lys Glu Asn 
                165                 170                 175     


Pro Gly Leu Val Glu Gln Tyr Leu Ser Ala Ile Leu Ser Leu Glu Pro 
            180                 185                 190         


Asn Gln Asn Tyr Ala Gly Met Leu Gly Leu Leu Val Gln Phe Cys Thr 
        195                 200                 205             


Ser His Lys Glu Met Asp Val Val Ser Gln His Lys Ser Ala Leu Leu 
    210                 215                 220                 


Asp Phe Tyr Met Lys Asn Ile Leu Met Ser Lys Val Lys Pro Pro Lys 
225                 230                 235                 240 


Tyr Leu Leu Asp Ser Cys Ala Pro Leu Leu Arg Tyr Leu Ser His Ser 
                245                 250                 255     


Glu Phe Lys Asp Leu Ile Leu Pro Thr Ile Gln Lys Ser Leu Leu Arg 
            260                 265                 270         


Ser Pro Glu Asn Val Ile Glu Thr Ile Ser Ser Leu Leu Ala Ser Val 
        275                 280                 285             


Thr Leu Asp Leu Ser Gln Tyr Ala Met Asp Ile Val Lys Gly Leu Ala 
    290                 295                 300                 


Gly His Leu Lys Ser Asn Ser Pro Arg Leu Met Asp Glu Ala Val Leu 
305                 310                 315                 320 


Ala Leu Arg Asn Leu Ala Arg Gln Cys Ser Asp Ser Ser Ala Met Glu 
                325                 330                 335     


Ser Leu Thr Lys His Leu Phe Ala Ile Leu Gly Gly Ser Glu Gly Lys 
            340                 345                 350         


Leu Thr Val Val Ala Gln Lys Met Ser Val Leu Ser Gly Ile Gly Ser 
        355                 360                 365             


Val Ser His His Val Val Ser Gly Pro Ser Ser Gln Val Leu Asn Gly 
    370                 375                 380                 


Ile Val Ala Glu Leu Phe Ile Pro Phe Leu Gln Gln Glu Val His Glu 
385                 390                 395                 400 


Gly Thr Leu Val His Ala Val Ser Val Leu Ala Leu Trp Cys Asn Arg 
                405                 410                 415     


Phe Thr Met Glu Val Pro Lys Lys Leu Thr Glu Trp Phe Lys Lys Ala 
            420                 425                 430         


Phe Ser Leu Lys Thr Ser Thr Ser Ala Val Arg His Ala Tyr Leu Gln 
        435                 440                 445             


Cys Met Leu Ala Ser Tyr Arg Gly Asp Thr Leu Leu Gln Ala Leu Asp 
    450                 455                 460                 


Leu Leu Pro Leu Leu Ile Gln Thr Val Glu Lys Ala Ala Ser Gln Ser 
465                 470                 475                 480 


Thr Gln Val Pro Thr Ile Thr Glu Gly Val Ala Ala Ala Leu Leu Leu 
                485                 490                 495     


Leu Lys Leu Ser Val Ala Asp Ser Gln Ala Glu Ala Lys Leu Ser Ser 
            500                 505                 510         


Phe Trp Gln Leu Ile Val Asp Glu Lys Lys Gln Val Phe Thr Ser Glu 
        515                 520                 525             


Lys Phe Leu Val Met Ala Ser Glu Asp Ala Leu Cys Thr Val Leu His 
    530                 535                 540                 


Leu Thr Glu Arg Leu Phe Leu Asp His Pro His Arg Leu Thr Gly Asn 
545                 550                 555                 560 


Lys Val Gln Gln Tyr His Arg Ala Leu Val Ala Val Leu Leu Ser Arg 
                565                 570                 575     


Thr Trp His Val Arg Arg Gln Ala Gln Gln Thr Val Arg Lys Leu Leu 
            580                 585                 590         


Ser Ser Leu Gly Gly Phe Lys Leu Ala His Gly Leu Leu Glu Glu Leu 
        595                 600                 605             


Lys Thr Val Leu Ser Ser His Lys Val Leu Pro Leu Glu Ala Leu Val 
    610                 615                 620                 


Thr Asp Ala Gly Glu Val Thr Glu Ala Gly Lys Ala Tyr Val Pro Pro 
625                 630                 635                 640 


Arg Val Leu Gln Glu Ala Leu Cys Val Ile Ser Gly Val Pro Gly Leu 
                645                 650                 655     


Lys Gly Asp Val Thr Asp Thr Glu Gln Leu Ala Gln Glu Met Leu Ile 
            660                 665                 670         


Ile Ser His His Pro Ser Leu Val Ala Val Gln Ser Gly Leu Trp Pro 
        675                 680                 685             


Ala Leu Leu Ala Arg Met Lys Ile Asp Pro Glu Ala Phe Ile Thr Arg 
    690                 695                 700                 


His Leu Asp Gln Ile Ile Pro Arg Met Thr Thr Gln Ser Pro Leu Asn 
705                 710                 715                 720 


Gln Ser Ser Met Asn Ala Met Gly Ser Leu Ser Val Leu Ser Pro Asp 
                725                 730                 735     


Arg Val Leu Pro Gln Leu Ile Ser Thr Ile Thr Ala Ser Val Gln Asn 
            740                 745                 750         


Pro Ala Leu Arg Leu Val Thr Arg Glu Glu Phe Ala Ile Met Gln Thr 
        755                 760                 765             


Pro Ala Gly Glu Leu Tyr Asp Lys Ser Ile Ile Gln Ser Ala Gln Gln 
    770                 775                 780                 


Asp Ser Ile Lys Lys Ala Asn Met Lys Arg Glu Asn Lys Ala Tyr Ser 
785                 790                 795                 800 


Phe Lys Glu Gln Ile Ile Glu Leu Glu Leu Lys Glu Glu Ile Lys Lys 
                805                 810                 815     


Lys Lys Gly Ile Lys Glu Glu Val Gln Leu Thr Ser Lys Gln Lys Glu 
            820                 825                 830         


Met Leu Gln Ala Gln Leu Asp Arg Glu Ala Gln Val Arg Arg Arg Leu 
        835                 840                 845             


Gln Glu Leu Asp Gly Glu Leu Glu Ala Ala Leu Gly Leu Leu Asp Ile 
    850                 855                 860                 


Ile Leu Ala Lys Asn Pro Ser Gly Leu Thr Gln Tyr Ile Pro Val Leu 
865                 870                 875                 880 


Val Asp Ser Phe Leu Pro Leu Leu Lys Ser Pro Leu Ala Ala Pro Arg 
                885                 890                 895     


Ile Lys Asn Pro Phe Leu Ser Leu Ala Ala Cys Val Met Pro Ser Arg 
            900                 905                 910         


Leu Lys Ala Leu Gly Thr Leu Val Ser His Val Thr Leu Arg Leu Leu 
        915                 920                 925             


Lys Pro Glu Cys Val Leu Asp Lys Ser Trp Cys Gln Glu Glu Leu Ser 
    930                 935                 940                 


Val Ala Val Lys Arg Ala Val Met Leu Leu His Thr His Thr Ile Thr 
945                 950                 955                 960 


Ser Arg Val Gly Lys Gly Glu Pro Gly Ala Ala Pro Leu Ser Ala Pro 
                965                 970                 975     


Ala Phe Ser Leu Val Phe Pro Phe Leu Lys Met Val Leu Thr Glu Met 
            980                 985                 990         


Pro His His Ser Glu Glu Glu Glu  Glu Trp Met Ala Gln  Ile Leu Gln 
        995                 1000                 1005             


Ile Leu  Thr Val Gln Ala Gln  Leu Arg Ala Ser Pro  Asn Thr Pro 
    1010                 1015                 1020             


Pro Gly  Arg Val Asp Glu Asn  Gly Pro Glu Leu Leu  Pro Arg Val 
    1025                 1030                 1035             


Ala Met  Leu Arg Leu Leu Thr  Trp Val Ile Gly Thr  Gly Ser Pro 
    1040                 1045                 1050             


Arg Leu  Gln Val Leu Ala Ser  Asp Thr Leu Thr Thr  Leu Cys Ala 
    1055                 1060                 1065             


Ser Ser  Ser Gly Asp Asp Gly  Cys Ala Phe Ala Glu  Gln Glu Glu 
    1070                 1075                 1080             


Val Asp  Val Leu Leu Cys Ala  Leu Gln Ser Pro Cys  Ala Ser Val 
    1085                 1090                 1095             


Arg Glu  Thr Val Leu Arg Gly  Leu Met Glu Leu His  Met Val Leu 
    1100                 1105                 1110             


Pro Ala  Pro Asp Thr Asp Glu  Lys Asn Gly Leu Asn  Leu Leu Arg 
    1115                 1120                 1125             


Arg Leu  Trp Val Val Lys Phe  Asp Lys Glu Glu Glu  Ile Arg Lys 
    1130                 1135                 1140             


Leu Ala  Glu Arg Leu Trp Ser  Met Met Gly Leu Asp  Leu Gln Pro 
    1145                 1150                 1155             


Asp Leu  Cys Ser Leu Leu Ile  Asp Asp Val Ile Tyr  His Glu Ala 
    1160                 1165                 1170             


Ala Val  Arg Gln Ala Gly Ala  Glu Ala Leu Ser Gln  Ala Val Ala 
    1175                 1180                 1185             


Arg Tyr  Gln Arg Gln Ala Ala  Glu Val Met Gly Arg  Leu Met Glu 
    1190                 1195                 1200             


Ile Tyr  Gln Glu Lys Leu Tyr  Arg Pro Pro Pro Val  Leu Asp Ala 
    1205                 1210                 1215             


Leu Gly  Arg Val Ile Ser Glu  Ser Pro Pro Asp Gln  Trp Glu Ala 
    1220                 1225                 1230             


Arg Cys  Gly Leu Ala Leu Ala  Leu Asn Lys Leu Ser  Gln Tyr Leu 
    1235                 1240                 1245             


Asp Ser  Ser Gln Val Lys Pro  Leu Phe Gln Phe Phe  Val Pro Asp 
    1250                 1255                 1260             


Ala Leu  Asn Asp Arg His Pro  Asp Val Arg Lys Cys  Met Leu Asp 
    1265                 1270                 1275             


Ala Ala  Leu Ala Thr Leu Asn  Thr His Gly Lys Glu  Asn Val Asn 
    1280                 1285                 1290             


Ser Leu  Leu Pro Val Phe Glu  Glu Phe Leu Lys Asn  Ala Pro Asn 
    1295                 1300                 1305             


Asp Ala  Ser Tyr Asp Ala Val  Arg Gln Ser Val Val  Val Leu Met 
    1310                 1315                 1320             


Gly Ser  Leu Ala Lys His Leu  Asp Lys Ser Asp Pro  Lys Val Lys 
    1325                 1330                 1335             


Pro Ile  Val Ala Lys Leu Ile  Ala Ala Leu Ser Thr  Pro Ser Gln 
    1340                 1345                 1350             


Gln Val  Gln Glu Ser Val Ala  Ser Cys Leu Pro Pro  Leu Val Pro 
    1355                 1360                 1365             


Ala Ile  Lys Glu Asp Ala Gly  Gly Met Ile Gln Arg  Leu Met Gln 
    1370                 1375                 1380             


Gln Leu  Leu Glu Ser Asp Lys  Tyr Ala Glu Arg Lys  Gly Ala Ala 
    1385                 1390                 1395             


Tyr Gly  Leu Ala Gly Leu Val  Lys Gly Leu Gly Ile  Leu Ser Leu 
    1400                 1405                 1410             


Lys Gln  Gln Glu Met Met Ala  Ala Leu Thr Asp Ala  Ile Gln Asp 
    1415                 1420                 1425             


Lys Lys  Asn Phe Arg Arg Arg  Glu Gly Ala Leu Phe  Ala Phe Glu 
    1430                 1435                 1440             


Met Leu  Cys Thr Met Leu Gly  Lys Leu Phe Glu Pro  Tyr Val Val 
    1445                 1450                 1455             


His Val  Leu Pro His Leu Leu  Leu Cys Phe Gly Asp  Gly Asn Gln 
    1460                 1465                 1470             


Tyr Val  Arg Glu Ala Ala Asp  Asp Cys Ala Lys Ala  Val Met Ser 
    1475                 1480                 1485             


Asn Leu  Ser Ala His Gly Val  Lys Leu Val Leu Pro  Ser Leu Leu 
    1490                 1495                 1500             


Ala Ala  Leu Glu Glu Glu Ser  Trp Arg Thr Lys Ala  Gly Ser Val 
    1505                 1510                 1515             


Glu Leu  Leu Gly Ala Met Ala  Tyr Cys Ala Pro Lys  Gln Leu Ser 
    1520                 1525                 1530             


Ser Cys  Leu Pro Asn Ile Val  Pro Lys Leu Thr Glu  Val Leu Thr 
    1535                 1540                 1545             


Asp Ser  His Val Lys Val Gln  Lys Ala Gly Gln Gln  Ala Leu Arg 
    1550                 1555                 1560             


Gln Ile  Gly Ser Val Ile Arg  Asn Pro Glu Ile Leu  Ala Ile Ala 
    1565                 1570                 1575             


Pro Val  Leu Leu Asp Ala Leu  Thr Asp Pro Ser Arg  Lys Thr Gln 
    1580                 1585                 1590             


Lys Cys  Leu Gln Thr Leu Leu  Asp Thr Lys Phe Val  His Phe Ile 
    1595                 1600                 1605             


Asp Ala  Pro Ser Leu Ala Leu  Ile Met Pro Ile Val  Gln Arg Ala 
    1610                 1615                 1620             


Phe Gln  Asp Arg Ser Thr Asp  Thr Arg Lys Met Ala  Ala Gln Ile 
    1625                 1630                 1635             


Ile Gly  Asn Met Tyr Ser Leu  Thr Asp Gln Lys Asp  Leu Ala Pro 
    1640                 1645                 1650             


Tyr Leu  Pro Ser Val Thr Pro  Gly Leu Lys Ala Ser  Leu Leu Asp 
    1655                 1660                 1665             


Pro Val  Pro Glu Val Arg Thr  Val Ser Ala Lys Ala  Leu Gly Ala 
    1670                 1675                 1680             


Met Val  Lys Gly Met Gly Glu  Ser Cys Phe Glu Asp  Leu Leu Pro 
    1685                 1690                 1695             


Trp Leu  Met Glu Thr Leu Thr  Tyr Glu Gln Ser Ser  Val Asp Arg 
    1700                 1705                 1710             


Ser Gly  Ala Ala Gln Gly Leu  Ala Glu Val Met Ala  Gly Leu Gly 
    1715                 1720                 1725             


Val Glu  Lys Leu Glu Lys Leu  Met Pro Glu Ile Val  Ala Thr Ala 
    1730                 1735                 1740             


Ser Lys  Val Asp Ile Ala Pro  His Val Arg Asp Gly  Tyr Ile Met 
    1745                 1750                 1755             


Met Phe  Asn Tyr Leu Pro Ile  Thr Phe Gly Asp Lys  Phe Thr Pro 
    1760                 1765                 1770             


Tyr Val  Gly Pro Ile Ile Pro  Cys Ile Leu Lys Ala  Leu Ala Asp 
    1775                 1780                 1785             


Glu Asn  Glu Phe Val Arg Asp  Thr Ala Leu Arg Ala  Gly Gln Arg 
    1790                 1795                 1800             


Val Ile  Ser Met Tyr Ala Glu  Thr Ala Ile Ala Leu  Leu Leu Pro 
    1805                 1810                 1815             


Gln Leu  Glu Gln Gly Leu Phe  Asp Asp Leu Trp Arg  Ile Arg Phe 
    1820                 1825                 1830             


Ser Ser  Val Gln Leu Leu Gly  Asp Leu Leu Phe His  Ile Ser Gly 
    1835                 1840                 1845             


Val Thr  Gly Lys Met Thr Thr  Glu Thr Ala Ser Glu  Asp Asp Asn 
    1850                 1855                 1860             


Phe Gly  Thr Ala Gln Ser Asn  Lys Ala Ile Ile Thr  Ala Leu Gly 
    1865                 1870                 1875             


Val Glu  Arg Arg Asn Arg Val  Leu Ala Gly Leu Tyr  Met Gly Arg 
    1880                 1885                 1890             


Ser Asp  Thr Gln Leu Val Val  Arg Gln Ala Ser Leu  His Val Trp 
    1895                 1900                 1905             


Lys Ile  Val Val Ser Asn Thr  Pro Arg Thr Leu Arg  Glu Ile Leu 
    1910                 1915                 1920             


Pro Thr  Leu Phe Gly Leu Leu  Leu Gly Phe Leu Ala  Ser Thr Cys 
    1925                 1930                 1935             


Ala Asp  Lys Arg Thr Ile Ala  Ala Arg Thr Leu Gly  Asp Leu Val 
    1940                 1945                 1950             


Arg Lys  Leu Gly Glu Lys Ile  Leu Pro Glu Ile Ile  Pro Ile Leu 
    1955                 1960                 1965             


Glu Glu  Gly Leu Arg Ser Gln  Lys Ser Asp Glu Arg  Gln Gly Val 
    1970                 1975                 1980             


Cys Ile  Gly Leu Ser Glu Ile  Met Lys Ser Thr Ser  Arg Asp Ala 
    1985                 1990                 1995             


Val Leu  Tyr Phe Ser Glu Ser  Leu Val Pro Thr Ala  Arg Lys Ala 
    2000                 2005                 2010             


Leu Cys  Asp Pro Leu Glu Glu  Val Arg Glu Ala Ala  Ala Lys Thr 
    2015                 2020                 2025             


Phe Glu  Gln Leu His Ser Thr  Ile Gly His Gln Ala  Leu Glu Asp 
    2030                 2035                 2040             


Ile Leu  Pro Phe Leu Leu Lys  Gln Leu Asp Asp Glu  Glu Val Ser 
    2045                 2050                 2055             


Glu Phe  Ala Leu Asp Gly Leu  Lys Gln Val Met Ala  Ile Lys Ser 
    2060                 2065                 2070             


Arg Val  Val Leu Pro Tyr Leu  Val Pro Lys Leu Thr  Thr Pro Pro 
    2075                 2080                 2085             


Val Asn  Thr Arg Val Leu Ala  Phe Leu Ser Ser Val  Ala Gly Asp 
    2090                 2095                 2100             


Ala Leu  Thr Arg His Leu Gly  Val Ile Leu Pro Ala  Val Met Leu 
    2105                 2110                 2115             


Ala Leu  Lys Glu Lys Leu Gly  Thr Pro Asp Glu Gln  Leu Glu Met 
    2120                 2125                 2130             


Ala Asn  Cys Gln Ala Val Ile  Leu Ser Val Glu Asp  Asp Thr Gly 
    2135                 2140                 2145             


His Arg  Ile Ile Ile Glu Asp  Leu Leu Glu Ala Thr  Arg Ser Pro 
    2150                 2155                 2160             


Glu Val  Gly Met Arg Gln Ala  Ala Ala Ile Ile Leu  Asn Ile Tyr 
    2165                 2170                 2175             


Cys Ser  Arg Ser Lys Ala Asp  Tyr Thr Ser His Leu  Arg Ser Leu 
    2180                 2185                 2190             


Val Ser  Gly Leu Ile Arg Leu  Phe Asn Asp Ser Ser  Pro Val Val 
    2195                 2200                 2205             


Leu Glu  Glu Ser Trp Asp Ala  Leu Asn Ala Ile Thr  Lys Lys Leu 
    2210                 2215                 2220             


Asp Ala  Gly Asn Gln Leu Ala  Leu Ile Glu Glu Leu  His Lys Glu 
    2225                 2230                 2235             


Ile Arg  Leu Ile Gly Asn Glu  Ser Lys Gly Glu His  Val Pro Gly 
    2240                 2245                 2250             


Phe Cys  Leu Pro Lys Lys Gly  Val Thr Ser Ile Leu  Pro Val Leu 
    2255                 2260                 2265             


Arg Glu  Gly Val Leu Thr Gly  Ser Pro Glu Gln Lys  Glu Glu Ala 
    2270                 2275                 2280             


Ala Lys  Ala Leu Gly Leu Val  Ile Arg Leu Thr Ser  Ala Asp Ala 
    2285                 2290                 2295             


Leu Arg  Pro Ser Val Val Ser  Ile Thr Gly Pro Leu  Ile Arg Ile 
    2300                 2305                 2310             


Leu Gly  Asp Arg Phe Ser Trp  Asn Val Lys Ala Ala  Leu Leu Glu 
    2315                 2320                 2325             


Thr Leu  Ser Leu Leu Leu Ala  Lys Val Gly Ile Ala  Leu Lys Pro 
    2330                 2335                 2340             


Phe Leu  Pro Gln Leu Gln Thr  Thr Phe Thr Lys Ala  Leu Gln Asp 
    2345                 2350                 2355             


Ser Asn  Arg Gly Val Arg Leu  Lys Ala Ala Asp Ala  Leu Gly Lys 
    2360                 2365                 2370             


Leu Ile  Ser Ile His Ile Lys  Val Asp Pro Leu Phe  Thr Glu Leu 
    2375                 2380                 2385             


Leu Asn  Gly Ile Arg Ala Met  Glu Asp Pro Gly Val  Arg Asp Thr 
    2390                 2395                 2400             


Met Leu  Gln Ala Leu Arg Phe  Val Ile Gln Gly Ala  Gly Ala Lys 
    2405                 2410                 2415             


Val Asp  Ala Val Ile Arg Lys  Asn Ile Val Ser Leu  Leu Leu Ser 
    2420                 2425                 2430             


Met Leu  Gly His Asp Glu Asp  Asn Thr Arg Ile Ser  Ser Ala Gly 
    2435                 2440                 2445             


Cys Leu  Gly Glu Leu Cys Ala  Phe Leu Thr Glu Glu  Glu Leu Ser 
    2450                 2455                 2460             


Ala Val  Leu Gln Gln Cys Leu  Leu Ala Asp Val Ser  Gly Ile Asp 
    2465                 2470                 2475             


Trp Met  Val Arg His Gly Arg  Ser Leu Ala Leu Ser  Val Ala Val 
    2480                 2485                 2490             


Asn Val  Ala Pro Gly Arg Leu  Cys Ala Gly Arg Tyr  Ser Ser Asp 
    2495                 2500                 2505             


Val Gln  Glu Met Ile Leu Ser  Ser Ala Thr Ala Asp  Arg Ile Pro 
    2510                 2515                 2520             


Ile Ala  Val Ser Gly Val Arg  Gly Met Gly Phe Leu  Met Arg His 
    2525                 2530                 2535             


His Ile  Glu Thr Gly Gly Gly  Gln Leu Pro Ala Lys  Leu Ser Ser 
    2540                 2545                 2550             


Leu Phe  Val Lys Cys Leu Gln  Asn Pro Ser Ser Asp  Ile Arg Leu 
    2555                 2560                 2565             


Val Ala  Glu Lys Met Ile Trp  Trp Ala Asn Lys Asp  Pro Leu Pro 
    2570                 2575                 2580             


Pro Leu  Asp Pro Gln Ala Ile  Lys Pro Ile Leu Lys  Ala Leu Leu 
    2585                 2590                 2595             


Asp Asn  Thr Lys Asp Lys Asn  Thr Val Val Arg Ala  Tyr Ser Asp 
    2600                 2605                 2610             


Gln Ala  Ile Val Asn Leu Leu  Lys Met Arg Gln Gly  Glu Glu Val 
    2615                 2620                 2625             


Phe Gln  Ser Leu Ser Lys Ile  Leu Asp Val Ala Ser  Leu Glu Val 
    2630                 2635                 2640             


Leu Asn  Glu Val Asn Arg Arg  Ser Leu Lys Lys Leu  Ala Ser Gln 
    2645                 2650                 2655             


Ala Asp  Ser Thr Glu Gln Val  Asp Asp Thr Ile Leu  Thr 
    2660                 2665                 2670     


<210>  4384
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCNT1__Homo_sapiens__XP_006717115

<400>  4384

Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210>  4385
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCNT2__Homo_sapiens__NP_001482

<400>  4385

Met Pro Leu Ser Met Arg Tyr Leu Phe Ile Ile Ser Val Ser Ser Val 
1               5                   10                  15      


Ile Ile Phe Ile Val Phe Ser Val Phe Asn Phe Gly Gly Asp Pro Ser 
            20                  25                  30          


Phe Gln Arg Leu Asn Ile Ser Asp Pro Leu Arg Leu Thr Gln Val Cys 
        35                  40                  45              


Thr Ser Phe Ile Asn Gly Lys Thr Arg Phe Leu Trp Lys Asn Lys Leu 
    50                  55                  60                  


Met Ile His Glu Lys Ser Ser Cys Lys Glu Tyr Leu Thr Gln Ser His 
65                  70                  75                  80  


Tyr Ile Thr Ala Pro Leu Ser Lys Glu Glu Ala Asp Phe Pro Leu Ala 
                85                  90                  95      


Tyr Ile Met Val Ile His His His Phe Asp Thr Phe Ala Arg Leu Phe 
            100                 105                 110         


Arg Ala Ile Tyr Met Pro Gln Asn Ile Tyr Cys Val His Val Asp Glu 
        115                 120                 125             


Lys Ala Thr Thr Glu Phe Lys Asp Ala Val Glu Gln Leu Leu Ser Cys 
    130                 135                 140                 


Phe Pro Asn Ala Phe Leu Ala Ser Lys Met Glu Pro Val Val Tyr Gly 
145                 150                 155                 160 


Gly Ile Ser Arg Leu Gln Ala Asp Leu Asn Cys Ile Arg Asp Leu Ser 
                165                 170                 175     


Ala Phe Glu Val Ser Trp Lys Tyr Val Ile Asn Thr Cys Gly Gln Asp 
            180                 185                 190         


Phe Pro Leu Lys Thr Asn Lys Glu Ile Val Gln Tyr Leu Lys Gly Phe 
        195                 200                 205             


Lys Gly Lys Asn Ile Thr Pro Gly Val Leu Pro Pro Ala His Ala Ile 
    210                 215                 220                 


Gly Arg Thr Lys Tyr Val His Gln Glu His Leu Gly Lys Glu Leu Ser 
225                 230                 235                 240 


Tyr Val Ile Arg Thr Thr Ala Leu Lys Pro Pro Pro Pro His Asn Leu 
                245                 250                 255     


Thr Ile Tyr Phe Gly Ser Ala Tyr Val Ala Leu Ser Arg Glu Phe Ala 
            260                 265                 270         


Asn Phe Val Leu His Asp Pro Arg Ala Val Asp Leu Leu Gln Trp Ser 
        275                 280                 285             


Lys Asp Thr Phe Ser Pro Asp Glu His Phe Trp Val Thr Leu Asn Arg 
    290                 295                 300                 


Ile Pro Gly Val Pro Gly Ser Met Pro Asn Ala Ser Trp Thr Gly Asn 
305                 310                 315                 320 


Leu Arg Ala Ile Lys Trp Ser Asp Met Glu Asp Arg His Gly Gly Cys 
                325                 330                 335     


His Gly His Tyr Val His Gly Ile Cys Ile Tyr Gly Asn Gly Asp Leu 
            340                 345                 350         


Lys Trp Leu Val Asn Ser Pro Ser Leu Phe Ala Asn Lys Phe Glu Leu 
        355                 360                 365             


Asn Thr Tyr Pro Leu Thr Val Glu Cys Leu Glu Leu Arg His Arg Glu 
    370                 375                 380                 


Arg Thr Leu Asn Gln Ser Glu Thr Ala Ile Gln Pro Ser Trp Tyr Phe 
385                 390                 395                 400 


<210>  4386
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCNT3__Homo_sapiens__NP_004742

<400>  4386

Met Val Gln Trp Lys Arg Leu Cys Gln Leu His Tyr Leu Trp Ala Leu 
1               5                   10                  15      


Gly Cys Tyr Met Leu Leu Ala Thr Val Ala Leu Lys Leu Ser Phe Arg 
            20                  25                  30          


Leu Lys Cys Asp Ser Asp His Leu Gly Leu Glu Ser Arg Glu Ser Gln 
        35                  40                  45              


Ser Gln Tyr Cys Arg Asn Ile Leu Tyr Asn Phe Leu Lys Leu Pro Ala 
    50                  55                  60                  


Lys Arg Ser Ile Asn Cys Ser Gly Val Thr Arg Gly Asp Gln Glu Ala 
65                  70                  75                  80  


Val Leu Gln Ala Ile Leu Asn Asn Leu Glu Val Lys Lys Lys Arg Glu 
                85                  90                  95      


Pro Phe Thr Asp Thr His Tyr Leu Ser Leu Thr Arg Asp Cys Glu His 
            100                 105                 110         


Phe Lys Ala Glu Arg Lys Phe Ile Gln Phe Pro Leu Ser Lys Glu Glu 
        115                 120                 125             


Val Glu Phe Pro Ile Ala Tyr Ser Met Val Ile His Glu Lys Ile Glu 
    130                 135                 140                 


Asn Phe Glu Arg Leu Leu Arg Ala Val Tyr Ala Pro Gln Asn Ile Tyr 
145                 150                 155                 160 


Cys Val His Val Asp Glu Lys Ser Pro Glu Thr Phe Lys Glu Ala Val 
                165                 170                 175     


Lys Ala Ile Ile Ser Cys Phe Pro Asn Val Phe Ile Ala Ser Lys Leu 
            180                 185                 190         


Val Arg Val Val Tyr Ala Ser Trp Ser Arg Val Gln Ala Asp Leu Asn 
        195                 200                 205             


Cys Met Glu Asp Leu Leu Gln Ser Ser Val Pro Trp Lys Tyr Phe Leu 
    210                 215                 220                 


Asn Thr Cys Gly Thr Asp Phe Pro Ile Lys Ser Asn Ala Glu Met Val 
225                 230                 235                 240 


Gln Ala Leu Lys Met Leu Asn Gly Arg Asn Ser Met Glu Ser Glu Val 
                245                 250                 255     


Pro Pro Lys His Lys Glu Thr Arg Trp Lys Tyr His Phe Glu Val Val 
            260                 265                 270         


Arg Asp Thr Leu His Leu Thr Asn Lys Lys Lys Asp Pro Pro Pro Tyr 
        275                 280                 285             


Asn Leu Thr Met Phe Thr Gly Asn Ala Tyr Ile Val Ala Ser Arg Asp 
    290                 295                 300                 


Phe Val Gln His Val Leu Lys Asn Pro Lys Ser Gln Gln Leu Ile Glu 
305                 310                 315                 320 


Trp Val Lys Asp Thr Tyr Ser Pro Asp Glu His Leu Trp Ala Thr Leu 
                325                 330                 335     


Gln Arg Ala Arg Trp Met Pro Gly Ser Val Pro Asn His Pro Lys Tyr 
            340                 345                 350         


Asp Ile Ser Asp Met Thr Ser Ile Ala Arg Leu Val Lys Trp Gln Gly 
        355                 360                 365             


His Glu Gly Asp Ile Asp Lys Gly Ala Pro Tyr Ala Pro Cys Ser Gly 
    370                 375                 380                 


Ile His Gln Arg Ala Ile Cys Val Tyr Gly Ala Gly Asp Leu Asn Trp 
385                 390                 395                 400 


Met Leu Gln Asn His His Leu Leu Ala Asn Lys Phe Asp Pro Lys Val 
                405                 410                 415     


Asp Asp Asn Ala Leu Gln Cys Leu Glu Glu Tyr Leu Arg Tyr Lys Ala 
            420                 425                 430         


Ile Tyr Gly Thr Glu Leu 
        435             


<210>  4387
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCNT7__Homo_sapiens__NP_542182

<400>  4387

Met Ser Gln Leu Arg Ala Thr Lys Ser Gly Leu Val Val Arg Ala Val 
1               5                   10                  15      


Ile Cys Ile Phe Ile Phe Leu Tyr Leu Arg Asn Pro Thr Pro Ala Glu 
            20                  25                  30          


Ser Glu Glu Glu Pro Ala Gln Pro Glu Val Val Glu Cys Gly Phe Tyr 
        35                  40                  45              


Pro Asp Glu Leu Cys Ser Ala Leu Phe Glu Gly Lys Gly Ala Ala Pro 
    50                  55                  60                  


Gln Ile Ala Lys Phe Cys Lys Thr Pro His Lys Ser Glu Ile His Ala 
65                  70                  75                  80  


His Leu His Thr Pro Gly Asn Cys Ser Arg Ile Ser Arg Gly Leu His 
                85                  90                  95      


Phe Ile Thr Arg Pro Leu Ser Ala Glu Glu Gly Asp Phe Ser Leu Ala 
            100                 105                 110         


Tyr Ile Ile Thr Ile His Lys Glu Leu Ala Met Phe Val Gln Leu Leu 
        115                 120                 125             


Arg Ala Ile Tyr Val Pro Gln Asn Val Tyr Cys Ile His Val Asp Glu 
    130                 135                 140                 


Lys Ala Pro Met Lys Tyr Lys Thr Ala Val Gln Thr Leu Val Asn Cys 
145                 150                 155                 160 


Phe Glu Asn Val Phe Ile Ser Ser Lys Thr Glu Lys Val Ala Tyr Ala 
                165                 170                 175     


Gly Phe Thr Arg Leu Gln Ala Asp Ile Asn Cys Met Lys Val Leu Val 
            180                 185                 190         


His Ser Lys Phe Gln Trp Asn Tyr Val Ile Asn Leu Cys Gly Gln Asp 
        195                 200                 205             


Phe Pro Ile Lys Thr Asn Arg Glu Ile Ile His Tyr Ile Arg Ser Lys 
    210                 215                 220                 


Trp Ser Asp Lys Asn Ile Thr Pro Gly Val Ile Gln Pro Leu His Ile 
225                 230                 235                 240 


Lys Ser Lys Thr Ser Gln Ser His Leu Glu Phe Val Pro Lys Gly Ser 
                245                 250                 255     


Ile Tyr Ala Pro Pro Asn Asn Arg Phe Lys Asp Lys Pro Pro His Asn 
            260                 265                 270         


Leu Thr Ile Tyr Phe Gly Ser Ala Tyr Tyr Val Leu Thr Arg Lys Phe 
        275                 280                 285             


Val Glu Phe Ile Leu Thr Asp Ile His Ala Lys Asp Met Leu Gln Trp 
    290                 295                 300                 


Ser Lys Asp Ile Arg Ser Pro Glu Gln His Tyr Trp Val Thr Leu Asn 
305                 310                 315                 320 


Arg Leu Lys Asp Ala Pro Gly Ala Thr Pro Asn Ala Gly Trp Glu Gly 
                325                 330                 335     


Asn Val Arg Ala Ile Lys Arg Lys Ser Glu Glu Gly Asn Val His Asp 
            340                 345                 350         


Gly Cys Lys Gly Arg Tyr Val Glu Asp Ile Cys Val Tyr Gly Pro Gly 
        355                 360                 365             


Asp Leu Pro Trp Leu Ile Gln Ser Pro Ser Leu Phe Ala Asn Lys Phe 
    370                 375                 380                 


Glu Pro Ser Thr Asp Pro Leu Val Val Thr Cys Leu Glu Arg Arg His 
385                 390                 395                 400 


Arg Leu Gln Val Leu Arg Gln Ala Glu Val Pro Ile Glu Pro His Trp 
                405                 410                 415     


His Phe Gln Gln Gln Ser His Phe Asn Met Arg Leu Asn Arg 
            420                 425                 430 


<210>  4388
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCOM1__Homo_sapiens__NP_001018100

<400>  4388

Met Leu Arg Ser Thr Ser Thr Val Thr Leu Leu Ser Gly Gly Ala Ala 
1               5                   10                  15      


Arg Thr Pro Gly Ala Pro Ser Arg Arg Ala Asn Val Cys Arg Leu Arg 
            20                  25                  30          


Leu Thr Val Pro Pro Glu Ser Pro Val Pro Glu Gln Cys Glu Lys Lys 
        35                  40                  45              


Ile Glu Arg Lys Glu Gln Leu Leu Asp Leu Ser Asn Gly Glu Pro Thr 
    50                  55                  60                  


Arg Lys Leu Pro Gln Gly Val Val Tyr Gly Val Val Arg Arg Ser Asp 
65                  70                  75                  80  


Gln Asn Gln Gln Lys Glu Met Val Val Tyr Gly Trp Ser Thr Ser Gln 
                85                  90                  95      


Leu Lys Glu Glu Met Asn Tyr Ile Lys Asp Val Arg Ala Thr Leu Glu 
            100                 105                 110         


Lys Val Arg Lys Arg Met Tyr Gly Asp Tyr Asp Glu Met Arg Gln Lys 
        115                 120                 125             


Ile Arg Gln Leu Thr Gln Glu Leu Ser Val Ser His Ala Gln Gln Glu 
    130                 135                 140                 


Tyr Leu Glu Asn His Ile Gln Thr Gln Ser Ser Ala Leu Asp Arg Phe 
145                 150                 155                 160 


Asn Ala Met Asn Ser Ala Leu Ala Ser Asp Ser Ile Gly Leu Gln Lys 
                165                 170                 175     


Thr Leu Val Asp Val Thr Leu Glu Asn Ser Asn Ile Lys Asp Gln Ile 
            180                 185                 190         


Arg Asn Leu Gln Gln Thr Tyr Glu Ala Ser Met Asp Lys Leu Arg Glu 
        195                 200                 205             


Lys Gln Arg Gln Leu Glu Val Ala Gln Val Glu Asn Gln Leu Leu Lys 
    210                 215                 220                 


Met Lys Val Glu Ser Ser Gln Glu Ala Asn Ala Glu Val Met Arg Glu 
225                 230                 235                 240 


Met Thr Lys Lys Leu Tyr Ser Gln Tyr Glu Glu Lys Leu Gln Glu Glu 
                245                 250                 255     


Gln Arg Lys His Ser Ala Glu Lys Glu Ala Leu Leu Glu Glu Thr Asn 
            260                 265                 270         


Ser Phe Leu Lys Ala Ile Glu Glu Ala Asn Lys Lys Met Gln Ala Ala 
        275                 280                 285             


Glu Ile Ser Leu Glu Glu Lys Asp Gln Arg Ile Gly Glu Leu Asp Arg 
    290                 295                 300                 


Leu Ile Glu Arg Met Glu Lys Glu Arg His Gln Leu Gln Leu Gln Leu 
305                 310                 315                 320 


Leu Glu His Glu Thr Glu Met Ser Gly Glu Leu Thr Asp Ser Asp Lys 
                325                 330                 335     


Glu Arg Tyr Gln Gln Leu Glu Glu Ala Ser Ala Ser Leu Arg Glu Arg 
            340                 345                 350         


Ile Arg His Leu Asp Asp Met Val His Cys Gln Gln Lys Lys Val Lys 
        355                 360                 365             


Gln Met Val Glu Glu Ile Glu Ser Leu Lys Lys Lys Leu Gln Gln Lys 
    370                 375                 380                 


Gln Leu Leu Ile Leu Gln Leu Leu Glu Lys Ile Ser Phe Leu Glu Gly 
385                 390                 395                 400 


Glu Asn Asn Glu Leu Gln Ser Arg Leu Asp Tyr Leu Thr Glu Thr Gln 
                405                 410                 415     


Ala Lys Thr Glu Val Glu Thr Arg Glu Ile Gly Val Gly Cys Asp Leu 
            420                 425                 430         


Leu Pro Arg Leu Pro Phe Arg Gln Asn Asp Ser Ser Ser His Cys Gln 
        435                 440                 445             


Lys Ser Gly Ser Pro Ile Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys 
    450                 455                 460                 


Gln His Leu Asp Asp Ile Thr Ala Ala Arg Leu Leu Pro Leu His His 
465                 470                 475                 480 


Met Pro Thr Gln Leu Leu Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys 
                485                 490                 495     


Gln Gln Lys Gln Asn Tyr Glu Glu Met Gln Ala Lys Leu Ala Ala Gln 
            500                 505                 510         


Lys Leu Ala Glu Arg Leu Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu 
        515                 520                 525             


Gly Glu Ser Ser Gly Arg Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp 
    530                 535                 540                 


Trp Ser Ser Asp Glu Phe 
545                 550 


<210>  4389
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCSAM__Homo_sapiens__NP_001177188

<400>  4389

Met Gly Asn Ser Leu Leu Arg Glu Asn Ser Phe Arg Arg Gln Gln Asn 
1               5                   10                  15      


Thr Gln Glu Met Pro Trp Asn Val Arg Met Gln Ser Pro Lys Gln Arg 
            20                  25                  30          


Thr Ser Arg Cys Trp Asp His His Ile Ala Glu Gly Cys Phe Cys Leu 
        35                  40                  45              


Pro Trp Lys Lys Ile Leu Ile Phe Glu Lys Arg Gln Asp Ser Gln Asn 
    50                  55                  60                  


Glu Asn Glu Arg Met Ser Ser Thr Pro Ile Gln Asp Asn Val Asp Gln 
65                  70                  75                  80  


Thr Tyr Ser Glu Glu Leu Cys Tyr Thr Leu Ile Asn His Arg Val Leu 
                85                  90                  95      


Cys Thr Arg Pro Ser Gly Asn Ser Ala Glu Glu Tyr Tyr Glu Asn Val 
            100                 105                 110         


Pro Cys Lys Ala Glu Arg Pro Arg Glu Ser Leu Gly Gly Thr Glu Thr 
        115                 120                 125             


Glu Tyr Ser Leu Leu His Met Pro Ser Thr Asp Pro Arg His Ala Arg 
    130                 135                 140                 


Ser Pro Glu Asp Glu Tyr Glu Leu Leu Met Pro His Arg Ile Ser Ser 
145                 150                 155                 160 


His Phe Leu Gln Gln Pro Arg Pro Leu Met Ala Pro Ser Glu Thr Gln 
                165                 170                 175     


Phe Ser His Leu 
            180 


<210>  4390
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCSAML__Homo_sapiens__NP_001268764

<400>  4390

Met Gly Asn Tyr Leu Leu Arg Lys Leu Arg Gln Glu Met Thr Thr Phe 
1               5                   10                  15      


Glu Arg Lys Leu Gln Asp Gln Asp Lys Lys Ser Gln Glu Val Ser Ser 
            20                  25                  30          


Thr Ser Asn Gln Glu Asn Glu Asn Gly Ser Gly Ser Glu Glu Val Cys 
        35                  40                  45              


Tyr Thr Val Ile Asn His Ile Pro His Gln Arg Ser Ser Leu Ser Ser 
    50                  55                  60                  


Asn Asp Asp Gly Tyr Glu Asn Ile Asp Ser Leu Thr Arg Lys Val Arg 
65                  70                  75                  80  


Gln Phe Arg Glu Arg Ser Glu Thr Glu Tyr Ala Leu Leu Arg Thr Ser 
                85                  90                  95      


Val Ser Arg Pro Cys Ser Cys Thr His Glu His Asp Tyr Glu Val Val 
            100                 105                 110         


Phe Pro His 
        115 


<210>  4391
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCSH__Homo_sapiens__NP_004474

<400>  4391

Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu 
1               5                   10                  15      


Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln 
            20                  25                  30          


Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu 
        35                  40                  45              


Ser Val Arg Lys Phe Thr Glu Lys His Glu Trp Val Thr Thr Glu Asn 
    50                  55                  60                  


Gly Ile Gly Thr Val Gly Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly 
65                  70                  75                  80  


Asp Val Val Tyr Cys Ser Leu Pro Glu Val Gly Thr Lys Leu Asn Lys 
                85                  90                  95      


Gln Asp Glu Phe Gly Ala Leu Glu Ser Val Lys Ala Ala Ser Glu Leu 
            100                 105                 110         


Tyr Ser Pro Leu Ser Gly Glu Val Thr Glu Ile Asn Glu Ala Leu Ala 
        115                 120                 125             


Glu Asn Pro Gly Leu Val Asn Lys Ser Cys Tyr Glu Asp Gly Trp Leu 
    130                 135                 140                 


Ile Lys Met Thr Leu Ser Asn Pro Ser Glu Leu Asp Glu Leu Met Ser 
145                 150                 155                 160 


Glu Glu Ala Tyr Glu Lys Tyr Ile Lys Ser Ile Glu Glu 
                165                 170             


<210>  4392
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDA__Homo_sapiens__NP_001229434

<400>  4392

Met Cys Ala Ala Gln Met Pro Pro Leu Ala His Ile Phe Arg Gly Thr 
1               5                   10                  15      


Phe Val His Ser Thr Trp Thr Cys Pro Met Glu Val Leu Arg Asp His 
            20                  25                  30          


Leu Leu Gly Val Ser Asp Ser Gly Lys Ile Val Phe Leu Glu Glu Ala 
        35                  40                  45              


Ser Gln Gln Glu Lys Leu Ala Lys Glu Trp Cys Phe Lys Pro Cys Glu 
    50                  55                  60                  


Ile Arg Glu Leu Ser His His Glu Phe Phe Met Pro Gly Leu Val Asp 
65                  70                  75                  80  


Thr His Ile His Ala Ser Gln Tyr Ser Phe Ala Gly Ser Ser Ile Asp 
                85                  90                  95      


Leu Pro Leu Leu Glu Trp Leu Thr Lys Tyr Thr Phe Pro Ala Glu His 
            100                 105                 110         


Arg Phe Gln Asn Ile Asp Phe Ala Glu Glu Val Tyr Thr Arg Val Val 
        115                 120                 125             


Arg Arg Thr Leu Lys Asn Gly Thr Thr Thr Ala Cys Tyr Phe Ala Thr 
    130                 135                 140                 


Ile His Thr Asp Ser Ser Leu Leu Leu Ala Asp Ile Thr Asp Lys Phe 
145                 150                 155                 160 


Gly Gln Arg Ala Phe Val Gly Lys Val Cys Met Asp Leu Asn Asp Thr 
                165                 170                 175     


Phe Pro Glu Tyr Lys Glu Thr Thr Glu Glu Ser Ile Lys Glu Thr Glu 
            180                 185                 190         


Arg Phe Val Ser Glu Met Leu Gln Lys Asn Tyr Ser Arg Val Lys Pro 
        195                 200                 205             


Ile Val Thr Pro Arg Phe Ser Leu Ser Cys Ser Glu Thr Leu Met Gly 
    210                 215                 220                 


Glu Leu Gly Asn Ile Ala Lys Thr Arg Asp Leu His Ile Gln Ser His 
225                 230                 235                 240 


Ile Ser Glu Asn Arg Asp Glu Val Glu Ala Val Lys Asn Leu Tyr Pro 
                245                 250                 255     


Ser Tyr Lys Asn Tyr Thr Ser Val Tyr Asp Lys Asn Asn Leu Leu Thr 
            260                 265                 270         


Asn Lys Thr Val Met Ala His Gly Cys Tyr Leu Ser Ala Glu Glu Leu 
        275                 280                 285             


Asn Val Phe His Glu Arg Gly Ala Ser Ile Ala His Cys Pro Asn Ser 
    290                 295                 300                 


Asn Leu Ser Leu Ser Ser Gly Phe Leu Asn Val Leu Glu Val Leu Lys 
305                 310                 315                 320 


His Glu Val Lys Ile Gly Leu Gly Thr Asp Val Ala Gly Gly Tyr Ser 
                325                 330                 335     


Tyr Ser Met Leu Asp Ala Ile Arg Arg Ala Val Met Val Ser Asn Ile 
            340                 345                 350         


Leu Leu Ile Asn Lys Val Asn Glu Lys Ser Leu Thr Leu Lys Glu Val 
        355                 360                 365             


Phe Arg Leu Ala Thr Leu Gly Gly Ser Gln Ala Leu Gly Leu Asp Gly 
    370                 375                 380                 


Glu Ile Gly Asn Phe Glu Val Gly Lys Glu Phe Asp Ala Ile Leu Ile 
385                 390                 395                 400 


Asn Pro Lys Ala Ser Asp Ser Pro Ile Asp Leu Phe Tyr Gly Asp Phe 
                405                 410                 415     


Phe Gly Asp Ile Ser Glu Ala Val Ile Gln Lys Phe Leu Tyr Leu Gly 
            420                 425                 430         


Asp Asp Arg Asn Ile Glu Glu Val Tyr Val Gly Gly Lys Gln Val Val 
        435                 440                 445             


Pro Phe Ser Ser Ser Val Lys Glu Thr Ile His Leu Pro Ala Ser Ser 
    450                 455                 460                 


Pro His Pro Pro Pro Phe Pro 
465                 470     


<210>  4393
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDAP1__Homo_sapiens__NP_001035808

<400>  4393

Met Arg Leu Asn Ser Thr Gly Glu Val Pro Val Leu Ile His Gly Glu 
1               5                   10                  15      


Asn Ile Ile Cys Glu Ala Thr Gln Ile Ile Asp Tyr Leu Glu Gln Thr 
            20                  25                  30          


Phe Leu Asp Glu Arg Thr Pro Arg Leu Met Pro Asp Lys Glu Ser Met 
        35                  40                  45              


Tyr Tyr Pro Arg Val Gln His Tyr Arg Glu Leu Leu Asp Ser Leu Pro 
    50                  55                  60                  


Met Asp Ala Tyr Thr His Gly Cys Ile Leu His Pro Glu Leu Thr Val 
65                  70                  75                  80  


Asp Ser Met Ile Pro Ala Tyr Ala Thr Thr Arg Ile Arg Ser Gln Ile 
                85                  90                  95      


Gly Asn Thr Glu Ser Glu Leu Lys Lys Leu Ala Glu Glu Asn Pro Asp 
            100                 105                 110         


Leu Gln Glu Ala Tyr Ile Ala Lys Gln Lys Arg Leu Lys Ser Lys Leu 
        115                 120                 125             


Leu Asp His Asp Asn Val Lys Tyr Leu Lys Lys Ile Leu Asp Glu Leu 
    130                 135                 140                 


Glu Lys Val Leu Asp Gln Val Glu Thr Glu Leu Gln Arg Arg Asn Glu 
145                 150                 155                 160 


Glu Thr Pro Glu Glu Gly Gln Gln Pro Trp Leu Cys Gly Glu Ser Phe 
                165                 170                 175     


Thr Leu Ala Asp Val Ser Leu Ala Val Thr Leu His Arg Leu Lys Phe 
            180                 185                 190         


Leu Gly Phe Ala Arg Arg Asn Trp Gly Asn Gly Lys Arg Pro Asn Leu 
        195                 200                 205             


Glu Thr Tyr Tyr Glu Arg Val Leu Lys Arg Lys Thr Phe Asn Lys Val 
    210                 215                 220                 


Leu Gly His Val Asn Asn Ile Leu Ile Ser Ala Val Leu Pro Thr Ala 
225                 230                 235                 240 


Phe Arg Val Ala Lys Lys Arg Ala Pro Lys Val Leu Gly Thr Thr Leu 
                245                 250                 255     


Val Val Gly Leu Leu Ala Gly Val Gly Tyr Phe Ala Phe Met Leu Phe 
            260                 265                 270         


Arg Lys Arg Leu Gly Ser Met Ile Leu Ala Phe Arg Pro Arg Pro Asn 
        275                 280                 285             


Tyr Phe 
    290 


<210>  4394
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDE1__Homo_sapiens__NP_057725

<400>  4394

Met Trp Leu Trp Glu Asp Gln Gly Gly Leu Leu Gly Pro Phe Ser Phe 
1               5                   10                  15      


Leu Leu Leu Val Leu Leu Leu Val Thr Arg Ser Pro Val Asn Ala Cys 
            20                  25                  30          


Leu Leu Thr Gly Ser Leu Phe Val Leu Leu Arg Val Phe Ser Phe Glu 
        35                  40                  45              


Pro Val Pro Ser Cys Arg Ala Leu Gln Val Leu Lys Pro Arg Asp Arg 
    50                  55                  60                  


Ile Ser Ala Ile Ala His Arg Gly Gly Ser His Asp Ala Pro Glu Asn 
65                  70                  75                  80  


Thr Leu Ala Ala Ile Arg Gln Ala Ala Lys Asn Gly Ala Thr Gly Val 
                85                  90                  95      


Glu Leu Asp Ile Glu Phe Thr Ser Asp Gly Ile Pro Val Leu Met His 
            100                 105                 110         


Asp Asn Thr Val Asp Arg Thr Thr Asp Gly Thr Gly Arg Leu Cys Asp 
        115                 120                 125             


Leu Thr Phe Glu Gln Ile Arg Lys Leu Asn Pro Ala Ala Asn His Arg 
    130                 135                 140                 


Leu Arg Asn Asp Phe Pro Asp Glu Lys Ile Pro Thr Leu Arg Glu Ala 
145                 150                 155                 160 


Val Ala Glu Cys Leu Asn His Asn Leu Thr Ile Phe Phe Asp Val Lys 
                165                 170                 175     


Gly His Ala His Lys Ala Thr Glu Ala Leu Lys Lys Met Tyr Met Glu 
            180                 185                 190         


Phe Pro Gln Leu Tyr Asn Asn Ser Val Val Cys Ser Phe Leu Pro Glu 
        195                 200                 205             


Val Ile Tyr Lys Met Arg Gln Thr Asp Arg Asp Val Ile Thr Ala Leu 
    210                 215                 220                 


Thr His Arg Pro Trp Ser Leu Ser His Thr Gly Asp Gly Lys Pro Arg 
225                 230                 235                 240 


Tyr Asp Thr Phe Trp Lys His Phe Ile Phe Val Met Met Asp Ile Leu 
                245                 250                 255     


Leu Asp Trp Ser Met His Asn Ile Leu Trp Tyr Leu Cys Gly Ile Ser 
            260                 265                 270         


Ala Phe Leu Met Gln Lys Asp Phe Val Ser Pro Ala Tyr Leu Lys Lys 
        275                 280                 285             


Trp Ser Ala Lys Gly Ile Gln Val Val Gly Trp Thr Val Asn Thr Phe 
    290                 295                 300                 


Asp Glu Lys Ser Tyr Tyr Glu Ser His Leu Gly Ser Ser Tyr Ile Thr 
305                 310                 315                 320 


Asp Ser Met Val Glu Asp Cys Glu Pro His Phe 
                325                 330     


<210>  4395
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF10__Homo_sapiens__NP_004953

<400>  4395

Met Ala His Val Pro Ala Arg Thr Ser Pro Gly Pro Gly Pro Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Phe Leu Leu Leu Leu Arg Asp Val Ala 
            20                  25                  30          


Gly Ser His Arg Ala Pro Ala Trp Ser Ala Leu Pro Ala Ala Ala Asp 
        35                  40                  45              


Gly Leu Gln Gly Asp Arg Asp Leu Gln Arg His Pro Gly Asp Ala Ala 
    50                  55                  60                  


Ala Thr Leu Gly Pro Ser Ala Gln Asp Met Val Ala Val His Met His 
65                  70                  75                  80  


Arg Leu Tyr Glu Lys Tyr Ser Arg Gln Gly Ala Arg Pro Gly Gly Gly 
                85                  90                  95      


Asn Thr Val Arg Ser Phe Arg Ala Arg Leu Glu Val Val Asp Gln Lys 
            100                 105                 110         


Ala Val Tyr Phe Phe Asn Leu Thr Ser Met Gln Asp Ser Glu Met Ile 
        115                 120                 125             


Leu Thr Ala Thr Phe His Phe Tyr Ser Glu Pro Pro Arg Trp Pro Arg 
    130                 135                 140                 


Ala Leu Glu Val Leu Cys Lys Pro Arg Ala Lys Asn Ala Ser Gly Arg 
145                 150                 155                 160 


Pro Leu Pro Leu Gly Pro Pro Thr Arg Gln His Leu Leu Phe Arg Ser 
                165                 170                 175     


Leu Ser Gln Asn Thr Ala Thr Gln Gly Leu Leu Arg Gly Ala Met Ala 
            180                 185                 190         


Leu Ala Pro Pro Pro Arg Gly Leu Trp Gln Ala Lys Asp Ile Ser Pro 
        195                 200                 205             


Ile Val Lys Ala Ala Arg Arg Asp Gly Glu Leu Leu Leu Ser Ala Gln 
    210                 215                 220                 


Leu Asp Ser Glu Glu Arg Asp Pro Gly Val Pro Arg Pro Ser Pro Tyr 
225                 230                 235                 240 


Ala Pro Tyr Ile Leu Val Tyr Ala Asn Asp Leu Ala Ile Ser Glu Pro 
                245                 250                 255     


Asn Ser Val Ala Val Thr Leu Gln Arg Tyr Asp Pro Phe Pro Ala Gly 
            260                 265                 270         


Asp Pro Glu Pro Arg Ala Ala Pro Asn Asn Ser Ala Asp Pro Arg Val 
        275                 280                 285             


Arg Arg Ala Ala Gln Ala Thr Gly Pro Leu Gln Asp Asn Glu Leu Pro 
    290                 295                 300                 


Gly Leu Asp Glu Arg Pro Pro Arg Ala His Ala Gln His Phe His Lys 
305                 310                 315                 320 


His Gln Leu Trp Pro Ser Pro Phe Arg Ala Leu Lys Pro Arg Pro Gly 
                325                 330                 335     


Arg Lys Asp Arg Arg Lys Lys Gly Gln Glu Val Phe Met Ala Ala Ser 
            340                 345                 350         


Gln Val Leu Asp Phe Asp Glu Lys Thr Met Gln Lys Ala Arg Arg Lys 
        355                 360                 365             


Gln Trp Asp Glu Pro Arg Val Cys Ser Arg Arg Tyr Leu Lys Val Asp 
    370                 375                 380                 


Phe Ala Asp Ile Gly Trp Asn Glu Trp Ile Ile Ser Pro Lys Ser Phe 
385                 390                 395                 400 


Asp Ala Tyr Tyr Cys Ala Gly Ala Cys Glu Phe Pro Met Pro Lys Ile 
                405                 410                 415     


Val Arg Pro Ser Asn His Ala Thr Ile Gln Ser Ile Val Arg Ala Val 
            420                 425                 430         


Gly Ile Ile Pro Gly Ile Pro Glu Pro Cys Cys Val Pro Asp Lys Met 
        435                 440                 445             


Asn Ser Leu Gly Val Leu Phe Leu Asp Glu Asn Arg Asn Val Val Leu 
    450                 455                 460                 


Lys Val Tyr Pro Asn Met Ser Val Asp Thr Cys Ala Cys Arg 
465                 470                 475             


<210>  4396
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF11__Homo_sapiens__XP_006719257

<400>  4396

Met Val Leu Ala Ala Pro Leu Leu Leu Gly Phe Leu Leu Leu Ala Leu 
1               5                   10                  15      


Glu Leu Arg Pro Arg Gly Glu Ala Ala Glu Gly Pro Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu Arg Ser 
        35                  40                  45              


Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp Gly Cys Pro Val 
    50                  55                  60                  


Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser Ile Lys 
65                  70                  75                  80  


Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn Ile Ser 
                85                  90                  95      


Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu Gln Gln 
            100                 105                 110         


Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro Glu Asp 
        115                 120                 125             


Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val Ile Ser 
    130                 135                 140                 


Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser Pro Leu 
145                 150                 155                 160 


Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys Val Leu 
                165                 170                 175     


Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro Ala Thr 
            180                 185                 190         


Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu Gly Thr 
        195                 200                 205             


Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg Ser Leu 
    210                 215                 220                 


Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile Asp Phe 
225                 230                 235                 240 


Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn Trp Gly 
                245                 250                 255     


Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala Val Thr 
            260                 265                 270         


Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu Leu Arg 
        275                 280                 285             


Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu Asp Cys 
    290                 295                 300                 


Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
305                 310                 315                 320 


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
                325                 330                 335     


Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys 
            340                 345                 350         


Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly Ser Ala 
        355                 360                 365             


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
    370                 375                 380                 


Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly Met Val 
385                 390                 395                 400 


Val Asp Arg Cys Gly Cys Ser 
                405         


<210>  4397
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF15__Homo_sapiens__NP_004855

<400>  4397

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  4398
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF1__Homo_sapiens__NP_001483

<400>  4398

Met Pro Pro Pro Gln Gln Gly Pro Cys Gly His His Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Leu Leu Pro Ser Leu Pro Leu Thr Arg Ala Pro Val Pro 
            20                  25                  30          


Pro Gly Pro Ala Ala Ala Leu Leu Gln Ala Leu Gly Leu Arg Asp Glu 
        35                  40                  45              


Pro Gln Gly Ala Pro Arg Leu Arg Pro Val Pro Pro Val Met Trp Arg 
    50                  55                  60                  


Leu Phe Arg Arg Arg Asp Pro Gln Glu Thr Arg Ser Gly Ser Arg Arg 
65                  70                  75                  80  


Thr Ser Pro Gly Val Thr Leu Gln Pro Cys His Val Glu Glu Leu Gly 
                85                  90                  95      


Val Ala Gly Asn Ile Val Arg His Ile Pro Asp Arg Gly Ala Pro Thr 
            100                 105                 110         


Arg Ala Ser Glu Pro Ala Ser Ala Ala Gly His Cys Pro Glu Trp Thr 
        115                 120                 125             


Val Val Phe Asp Leu Ser Ala Val Glu Pro Ala Glu Arg Pro Ser Arg 
    130                 135                 140                 


Ala Arg Leu Glu Leu Arg Phe Ala Ala Ala Ala Ala Ala Ala Pro Glu 
145                 150                 155                 160 


Gly Gly Trp Glu Leu Ser Val Ala Gln Ala Gly Gln Gly Ala Gly Ala 
                165                 170                 175     


Asp Pro Gly Pro Val Leu Leu Arg Gln Leu Val Pro Ala Leu Gly Pro 
            180                 185                 190         


Pro Val Arg Ala Glu Leu Leu Gly Ala Ala Trp Ala Arg Asn Ala Ser 
        195                 200                 205             


Trp Pro Arg Ser Leu Arg Leu Ala Leu Ala Leu Arg Pro Arg Ala Pro 
    210                 215                 220                 


Ala Ala Cys Ala Arg Leu Ala Glu Ala Ser Leu Leu Leu Val Thr Leu 
225                 230                 235                 240 


Asp Pro Arg Leu Cys His Pro Leu Ala Arg Pro Arg Arg Asp Ala Glu 
                245                 250                 255     


Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala Arg Arg Leu 
            260                 265                 270         


Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val Ile Ala Pro 
        275                 280                 285             


Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala Leu Pro Val 
    290                 295                 300                 


Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His Ala Val Leu 
305                 310                 315                 320 


Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp Leu Pro Cys 
                325                 330                 335     


Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe Phe Asp Asn 
            340                 345                 350         


Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val Val Asp Glu 
        355                 360                 365             


Cys Gly Cys Arg 
    370         


<210>  4399
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF2__Homo_sapiens__NP_057288

<400>  4399

Met Cys Pro Gly Ala Leu Trp Val Ala Leu Pro Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ala Gly Ser Leu Gln Gly Lys Pro Leu Gln Ser Trp Gly Arg Gly Ser 
            20                  25                  30          


Ala Gly Gly Asn Ala His Ser Pro Leu Gly Val Pro Gly Gly Gly Leu 
        35                  40                  45              


Pro Glu His Thr Phe Asn Leu Lys Met Phe Leu Glu Asn Val Lys Val 
    50                  55                  60                  


Asp Phe Leu Arg Ser Leu Asn Leu Ser Gly Val Pro Ser Gln Asp Lys 
65                  70                  75                  80  


Thr Arg Val Glu Pro Pro Gln Tyr Met Ile Asp Leu Tyr Asn Arg Tyr 
                85                  90                  95      


Thr Ser Asp Lys Ser Thr Thr Pro Ala Ser Asn Ile Val Arg Ser Phe 
            100                 105                 110         


Ser Met Glu Asp Ala Ile Ser Ile Thr Ala Thr Glu Asp Phe Pro Phe 
        115                 120                 125             


Gln Lys His Ile Leu Leu Phe Asn Ile Ser Ile Pro Arg His Glu Gln 
    130                 135                 140                 


Ile Thr Arg Ala Glu Leu Arg Leu Tyr Val Ser Cys Gln Asn His Val 
145                 150                 155                 160 


Asp Pro Ser His Asp Leu Lys Gly Ser Val Val Ile Tyr Asp Val Leu 
                165                 170                 175     


Asp Gly Thr Asp Ala Trp Asp Ser Ala Thr Glu Thr Lys Thr Phe Leu 
            180                 185                 190         


Val Ser Gln Asp Ile Gln Asp Glu Gly Trp Glu Thr Leu Glu Val Ser 
        195                 200                 205             


Ser Ala Val Lys Arg Trp Val Arg Ser Asp Ser Thr Lys Ser Lys Asn 
    210                 215                 220                 


Lys Leu Glu Val Thr Val Glu Ser His Arg Lys Gly Cys Asp Thr Leu 
225                 230                 235                 240 


Asp Ile Ser Val Pro Pro Gly Ser Arg Asn Leu Pro Phe Phe Val Val 
                245                 250                 255     


Phe Ser Asn Asp His Ser Ser Gly Thr Lys Glu Thr Arg Leu Glu Leu 
            260                 265                 270         


Arg Glu Met Ile Ser His Glu Gln Glu Ser Val Leu Lys Lys Leu Ser 
        275                 280                 285             


Lys Asp Gly Ser Thr Glu Ala Gly Glu Ser Ser His Glu Glu Asp Thr 
    290                 295                 300                 


Asp Gly His Val Ala Ala Gly Ser Thr Leu Ala Arg Arg Lys Arg Ser 
305                 310                 315                 320 


Ala Gly Ala Gly Ser His Cys Gln Lys Thr Ser Leu Arg Val Asn Phe 
                325                 330                 335     


Glu Asp Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Lys Glu Tyr Glu 
            340                 345                 350         


Ala Tyr Glu Cys Lys Gly Gly Cys Phe Phe Pro Leu Ala Asp Asp Val 
        355                 360                 365             


Thr Pro Thr Lys His Ala Ile Val Gln Thr Leu Val His Leu Lys Phe 
    370                 375                 380                 


Pro Thr Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu Ser Pro 
385                 390                 395                 400 


Ile Ser Val Leu Tyr Lys Asp Asp Met Gly Val Pro Thr Leu Lys Tyr 
                405                 410                 415     


His Tyr Glu Gly Met Ser Val Ala Glu Cys Gly Cys Arg 
            420                 425                 


<210>  4400
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF3__Homo_sapiens__NP_065685

<400>  4400

Met Leu Arg Phe Leu Pro Asp Leu Ala Phe Ser Phe Leu Leu Ile Leu 
1               5                   10                  15      


Ala Leu Gly Gln Ala Val Gln Phe Gln Glu Tyr Val Phe Leu Gln Phe 
            20                  25                  30          


Leu Gly Leu Asp Lys Ala Pro Ser Pro Gln Lys Phe Gln Pro Val Pro 
        35                  40                  45              


Tyr Ile Leu Lys Lys Ile Phe Gln Asp Arg Glu Ala Ala Ala Thr Thr 
    50                  55                  60                  


Gly Val Ser Arg Asp Leu Cys Tyr Val Lys Glu Leu Gly Val Arg Gly 
65                  70                  75                  80  


Asn Val Leu Arg Phe Leu Pro Asp Gln Gly Phe Phe Leu Tyr Pro Lys 
                85                  90                  95      


Lys Ile Ser Gln Ala Ser Ser Cys Leu Gln Lys Leu Leu Tyr Phe Asn 
            100                 105                 110         


Leu Ser Ala Ile Lys Glu Arg Glu Gln Leu Thr Leu Ala Gln Leu Gly 
        115                 120                 125             


Leu Asp Leu Gly Pro Asn Ser Tyr Tyr Asn Leu Gly Pro Glu Leu Glu 
    130                 135                 140                 


Leu Ala Leu Phe Leu Val Gln Glu Pro His Val Trp Gly Gln Thr Thr 
145                 150                 155                 160 


Pro Lys Pro Gly Lys Met Phe Val Leu Arg Ser Val Pro Trp Pro Gln 
                165                 170                 175     


Gly Ala Val His Phe Asn Leu Leu Asp Val Ala Lys Asp Trp Asn Asp 
            180                 185                 190         


Asn Pro Arg Lys Asn Phe Gly Leu Phe Leu Glu Ile Leu Val Lys Glu 
        195                 200                 205             


Asp Arg Asp Ser Gly Val Asn Phe Gln Pro Glu Asp Thr Cys Ala Arg 
    210                 215                 220                 


Leu Arg Cys Ser Leu His Ala Ser Leu Leu Val Val Thr Leu Asn Pro 
225                 230                 235                 240 


Asp Gln Cys His Pro Ser Arg Lys Arg Arg Ala Ala Ile Pro Val Pro 
                245                 250                 255     


Lys Leu Ser Cys Lys Asn Leu Cys His Arg His Gln Leu Phe Ile Asn 
            260                 265                 270         


Phe Arg Asp Leu Gly Trp His Lys Trp Ile Ile Ala Pro Lys Gly Phe 
        275                 280                 285             


Met Ala Asn Tyr Cys His Gly Glu Cys Pro Phe Ser Leu Thr Ile Ser 
    290                 295                 300                 


Leu Asn Ser Ser Asn Tyr Ala Phe Met Gln Ala Leu Met His Ala Val 
305                 310                 315                 320 


Asp Pro Glu Ile Pro Gln Ala Val Cys Ile Pro Thr Lys Leu Ser Pro 
                325                 330                 335     


Ile Ser Met Leu Tyr Gln Asp Asn Asn Asp Asn Val Ile Leu Arg His 
            340                 345                 350         


Tyr Glu Asp Met Val Val Asp Glu Cys Gly Cys Gly 
        355                 360                 


<210>  4401
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF5__Homo_sapiens__NP_001306067

<400>  4401

Met Arg Leu Pro Lys Leu Leu Thr Phe Leu Leu Trp Tyr Leu Ala Trp 
1               5                   10                  15      


Leu Asp Leu Glu Phe Ile Cys Thr Val Leu Gly Ala Pro Asp Leu Gly 
            20                  25                  30          


Gln Arg Pro Gln Gly Thr Arg Pro Gly Leu Ala Lys Ala Glu Ala Lys 
        35                  40                  45              


Glu Arg Pro Pro Leu Ala Arg Asn Val Phe Arg Pro Gly Gly His Ser 
    50                  55                  60                  


Tyr Gly Gly Gly Ala Thr Asn Ala Asn Ala Arg Ala Lys Gly Gly Thr 
65                  70                  75                  80  


Gly Gln Thr Gly Gly Leu Thr Gln Pro Lys Lys Asp Glu Pro Lys Lys 
                85                  90                  95      


Leu Pro Pro Arg Pro Gly Gly Pro Glu Pro Lys Pro Gly His Pro Pro 
            100                 105                 110         


Gln Thr Arg Gln Ala Thr Ala Arg Thr Val Thr Pro Lys Gly Gln Leu 
        115                 120                 125             


Pro Gly Gly Lys Ala Pro Pro Lys Ala Gly Ser Val Pro Ser Ser Phe 
    130                 135                 140                 


Leu Leu Lys Lys Ala Arg Glu Pro Gly Pro Pro Arg Glu Pro Lys Glu 
145                 150                 155                 160 


Pro Phe Arg Pro Pro Pro Ile Thr Pro His Glu Tyr Met Leu Ser Leu 
                165                 170                 175     


Tyr Arg Thr Leu Ser Asp Ala Asp Arg Lys Gly Gly Asn Ser Ser Val 
            180                 185                 190         


Lys Leu Glu Ala Gly Leu Ala Asn Thr Ile Thr Ser Phe Ile Asp Lys 
        195                 200                 205             


Gly Gln Asp Asp Arg Gly Pro Val Val Arg Lys Gln Arg Tyr Val Phe 
    210                 215                 220                 


Asp Ile Ser Ala Leu Glu Lys Asp Gly Leu Leu Gly Ala Glu Leu Arg 
225                 230                 235                 240 


Ile Leu Arg Lys Lys Pro Ser Asp Thr Ala Lys Pro Ala Ala Pro Gly 
                245                 250                 255     


Gly Gly Arg Ala Ala Gln Leu Lys Leu Ser Ser Cys Pro Ser Gly Arg 
            260                 265                 270         


Gln Pro Ala Ala Leu Leu Asp Val Arg Ser Val Pro Gly Leu Asp Gly 
        275                 280                 285             


Ser Gly Trp Glu Val Phe Asp Ile Trp Lys Leu Phe Arg Asn Phe Lys 
    290                 295                 300                 


Asn Ser Ala Gln Leu Cys Leu Glu Leu Glu Ala Trp Glu Arg Gly Arg 
305                 310                 315                 320 


Ala Val Asp Leu Arg Gly Leu Gly Phe Asp Arg Ala Ala Arg Gln Val 
                325                 330                 335     


His Glu Lys Ala Leu Phe Leu Val Phe Gly Arg Thr Lys Lys Arg Asp 
            340                 345                 350         


Leu Phe Phe Asn Glu Ile Lys Ala Arg Ser Gly Gln Asp Asp Lys Thr 
        355                 360                 365             


Val Tyr Glu Tyr Leu Phe Ser Gln Arg Arg Lys Arg Arg Ala Pro Leu 
    370                 375                 380                 


Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys Ala Arg Cys 
385                 390                 395                 400 


Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly Trp Asp Asp 
                405                 410                 415     


Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys Glu Gly Leu 
            420                 425                 430         


Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Val 
        435                 440                 445             


Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr Pro Pro Thr 
    450                 455                 460                 


Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu Phe Ile Asp 
465                 470                 475                 480 


Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu 
                485                 490                 495     


Ser Cys Gly Cys Arg 
            500     


<210>  4402
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF6__Homo_sapiens__NP_001001557

<400>  4402

Met Asp Thr Pro Arg Val Leu Leu Ser Ala Val Phe Leu Ile Ser Phe 
1               5                   10                  15      


Leu Trp Asp Leu Pro Gly Phe Gln Gln Ala Ser Ile Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Ala Glu Leu Gly Ser Thr Lys Gly Met Arg Ser Arg Lys Glu 
        35                  40                  45              


Gly Lys Met Gln Arg Ala Pro Arg Asp Ser Asp Ala Gly Arg Glu Gly 
    50                  55                  60                  


Gln Glu Pro Gln Pro Arg Pro Gln Asp Glu Pro Arg Ala Gln Gln Pro 
65                  70                  75                  80  


Arg Ala Gln Glu Pro Pro Gly Arg Gly Pro Arg Val Val Pro His Glu 
                85                  90                  95      


Tyr Met Leu Ser Ile Tyr Arg Thr Tyr Ser Ile Ala Glu Lys Leu Gly 
            100                 105                 110         


Ile Asn Ala Ser Phe Phe Gln Ser Ser Lys Ser Ala Asn Thr Ile Thr 
        115                 120                 125             


Ser Phe Val Asp Arg Gly Leu Asp Asp Leu Ser His Thr Pro Leu Arg 
    130                 135                 140                 


Arg Gln Lys Tyr Leu Phe Asp Val Ser Met Leu Ser Asp Lys Glu Glu 
145                 150                 155                 160 


Leu Val Gly Ala Glu Leu Arg Leu Phe Arg Gln Ala Pro Ser Ala Pro 
                165                 170                 175     


Trp Gly Pro Pro Ala Gly Pro Leu His Val Gln Leu Phe Pro Cys Leu 
            180                 185                 190         


Ser Pro Leu Leu Leu Asp Ala Arg Thr Leu Asp Pro Gln Gly Ala Pro 
        195                 200                 205             


Pro Ala Gly Trp Glu Val Phe Asp Val Trp Gln Gly Leu Arg His Gln 
    210                 215                 220                 


Pro Trp Lys Gln Leu Cys Leu Glu Leu Arg Ala Ala Trp Gly Glu Leu 
225                 230                 235                 240 


Asp Ala Gly Glu Ala Glu Ala Arg Ala Arg Gly Pro Gln Gln Pro Pro 
                245                 250                 255     


Pro Pro Asp Leu Arg Ser Leu Gly Phe Gly Arg Arg Val Arg Pro Pro 
            260                 265                 270         


Gln Glu Arg Ala Leu Leu Val Val Phe Thr Arg Ser Gln Arg Lys Asn 
        275                 280                 285             


Leu Phe Ala Glu Met Arg Glu Gln Leu Gly Ser Ala Glu Ala Ala Gly 
    290                 295                 300                 


Pro Gly Ala Gly Ala Glu Gly Ser Trp Pro Pro Pro Ser Gly Ala Pro 
305                 310                 315                 320 


Asp Ala Arg Pro Trp Leu Pro Ser Pro Gly Arg Arg Arg Arg Arg Thr 
                325                 330                 335     


Ala Phe Ala Ser Arg His Gly Lys Arg His Gly Lys Lys Ser Arg Leu 
            340                 345                 350         


Arg Cys Ser Lys Lys Pro Leu His Val Asn Phe Lys Glu Leu Gly Trp 
        355                 360                 365             


Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Tyr His Cys Glu 
    370                 375                 380                 


Gly Val Cys Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn His 
385                 390                 395                 400 


Ala Ile Ile Gln Thr Leu Met Asn Ser Met Asp Pro Gly Ser Thr Pro 
                405                 410                 415     


Pro Ser Cys Cys Val Pro Thr Lys Leu Thr Pro Ile Ser Ile Leu Tyr 
            420                 425                 430         


Ile Asp Ala Gly Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val 
        435                 440                 445             


Val Glu Ser Cys Gly Cys Arg 
    450                 455 


<210>  4403
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF7__Homo_sapiens__NP_878248

<400>  4403

Met Asp Leu Ser Ala Ala Ala Ala Leu Cys Leu Trp Leu Leu Ser Ala 
1               5                   10                  15      


Cys Arg Pro Arg Asp Gly Leu Glu Ala Ala Ala Val Leu Arg Ala Ala 
            20                  25                  30          


Gly Ala Gly Pro Val Arg Ser Pro Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Arg Thr Leu Ala Gln Ala Ala Gly Ala Ala Ala Val Pro Ala 
    50                  55                  60                  


Ala Ala Val Pro Arg Ala Arg Ala Ala Arg Arg Ala Ala Gly Ser Gly 
65                  70                  75                  80  


Phe Arg Asn Gly Ser Val Val Pro His His Phe Met Met Ser Leu Tyr 
                85                  90                  95      


Arg Ser Leu Ala Gly Arg Ala Pro Ala Gly Ala Ala Ala Val Ser Ala 
            100                 105                 110         


Ser Gly His Gly Arg Ala Asp Thr Ile Thr Gly Phe Thr Asp Gln Ala 
        115                 120                 125             


Thr Gln Asp Glu Ser Ala Ala Glu Thr Gly Gln Ser Phe Leu Phe Asp 
    130                 135                 140                 


Val Ser Ser Leu Asn Asp Ala Asp Glu Val Val Gly Ala Glu Leu Arg 
145                 150                 155                 160 


Val Leu Arg Arg Gly Ser Pro Glu Ser Gly Pro Gly Ser Trp Thr Ser 
                165                 170                 175     


Pro Pro Leu Leu Leu Leu Ser Thr Cys Pro Gly Ala Ala Arg Ala Pro 
            180                 185                 190         


Arg Leu Leu Tyr Ser Arg Ala Ala Glu Pro Leu Val Gly Gln Arg Trp 
        195                 200                 205             


Glu Ala Phe Asp Val Ala Asp Ala Met Arg Arg His Arg Arg Glu Pro 
    210                 215                 220                 


Arg Pro Pro Arg Ala Phe Cys Leu Leu Leu Arg Ala Val Ala Gly Pro 
225                 230                 235                 240 


Val Pro Ser Pro Leu Ala Leu Arg Arg Leu Gly Phe Gly Trp Pro Gly 
                245                 250                 255     


Gly Gly Gly Ser Ala Ala Glu Glu Arg Ala Val Leu Val Val Ser Ser 
            260                 265                 270         


Arg Thr Gln Arg Lys Glu Ser Leu Phe Arg Glu Ile Arg Ala Gln Ala 
        275                 280                 285             


Arg Ala Leu Gly Ala Ala Leu Ala Ser Glu Pro Leu Pro Asp Pro Gly 
    290                 295                 300                 


Thr Gly Thr Ala Ser Pro Arg Ala Val Ile Gly Gly Arg Arg Arg Arg 
305                 310                 315                 320 


Arg Thr Ala Leu Ala Gly Thr Arg Thr Ala Gln Gly Ser Gly Gly Gly 
                325                 330                 335     


Ala Gly Arg Gly His Gly Arg Arg Gly Arg Ser Arg Cys Ser Arg Lys 
            340                 345                 350         


Pro Leu His Val Asp Phe Lys Glu Leu Gly Trp Asp Asp Trp Ile Ile 
        355                 360                 365             


Ala Pro Leu Asp Tyr Glu Ala Tyr His Cys Glu Gly Leu Cys Asp Phe 
    370                 375                 380                 


Pro Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Ile Ile Gln Thr 
385                 390                 395                 400 


Leu Leu Asn Ser Met Ala Pro Asp Ala Ala Pro Ala Ser Cys Cys Val 
                405                 410                 415     


Pro Ala Arg Leu Ser Pro Ile Ser Ile Leu Tyr Ile Asp Ala Ala Asn 
            420                 425                 430         


Asn Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu Ala Cys Gly 
        435                 440                 445             


Cys Arg 
    450 


<210>  4404
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDF9__Homo_sapiens__XP_011541610

<400>  4404

Met Ala Arg Pro Asn Lys Phe Leu Leu Trp Phe Cys Cys Phe Ala Trp 
1               5                   10                  15      


Leu Cys Phe Pro Ile Ser Leu Gly Ser Gln Ala Ser Gly Gly Glu Ala 
            20                  25                  30          


Gln Ile Ala Ala Ser Ala Glu Leu Glu Ser Gly Ala Met Pro Trp Ser 
        35                  40                  45              


Leu Leu Gln His Ile Asp Glu Arg Asp Arg Ala Gly Leu Leu Pro Ala 
    50                  55                  60                  


Leu Phe Lys Val Leu Ser Val Gly Arg Gly Gly Ser Pro Arg Leu Gln 
65                  70                  75                  80  


Pro Asp Ser Arg Ala Leu His Tyr Met Lys Lys Leu Tyr Lys Thr Tyr 
                85                  90                  95      


Ala Thr Lys Glu Gly Ile Pro Lys Ser Asn Arg Ser His Leu Tyr Asn 
            100                 105                 110         


Thr Val Arg Leu Phe Thr Pro Cys Thr Arg His Lys Gln Ala Pro Gly 
        115                 120                 125             


Asp Gln Val Thr Gly Ile Leu Pro Ser Val Glu Leu Leu Phe Asn Leu 
    130                 135                 140                 


Asp Arg Ile Thr Thr Val Glu His Leu Leu Lys Ser Val Leu Leu Tyr 
145                 150                 155                 160 


Asn Ile Asn Asn Ser Val Ser Phe Ser Ser Ala Val Lys Cys Val Cys 
                165                 170                 175     


Asn Leu Met Ile Lys Glu Pro Lys Ser Ser Ser Arg Thr Leu Gly Arg 
            180                 185                 190         


Ala Pro Tyr Ser Phe Thr Phe Asn Ser Gln Phe Glu Phe Gly Lys Lys 
        195                 200                 205             


His Lys Trp Ile Gln Ile Asp Val Thr Ser Leu Leu Gln Pro Leu Val 
    210                 215                 220                 


Ala Ser Asn Lys Arg Ser Ile His Met Ser Ile Asn Phe Thr Cys Met 
225                 230                 235                 240 


Lys Asp Gln Leu Glu His Pro Ser Ala Gln Asn Gly Leu Phe Asn Met 
                245                 250                 255     


Thr Leu Val Ser Pro Ser Leu Ile Leu Tyr Leu Asn Asp Thr Ser Ala 
            260                 265                 270         


Gln Ala Tyr His Ser Trp Tyr Ser Leu His Tyr Lys Arg Arg Pro Ser 
        275                 280                 285             


Gln Gly Pro Asp Gln Glu Arg Ser Leu Ser Ala Tyr Pro Val Gly Glu 
    290                 295                 300                 


Glu Ala Ala Glu Asp Gly Arg Ser Ser His His Arg His Arg Arg Gly 
305                 310                 315                 320 


Gln Glu Thr Val Ser Ser Glu Leu Lys Lys Pro Leu Gly Pro Ala Ser 
                325                 330                 335     


Phe Asn Leu Ser Glu Tyr Phe Arg Gln Phe Leu Leu Pro Gln Asn Glu 
            340                 345                 350         


Cys Glu Leu His Asp Phe Arg Leu Ser Phe Ser Gln Leu Lys Trp Asp 
        355                 360                 365             


Asn Trp Ile Val Ala Pro His Arg Tyr Asn Pro Arg Tyr Cys Lys Gly 
    370                 375                 380                 


Asp Cys Pro Arg Ala Val Gly His Arg Tyr Gly Ser Pro Val His Thr 
385                 390                 395                 400 


Met Val Gln Asn Ile Ile Tyr Glu Lys Leu Asp Ser Ser Val Pro Arg 
                405                 410                 415     


Pro Ser Cys Val Pro Ala Lys Tyr Ser Pro Leu Ser Val Leu Thr Ile 
            420                 425                 430         


Glu Pro Asp Gly Ser Ile Ala Tyr Lys Glu Tyr Glu Asp Met Ile Ala 
        435                 440                 445             


Thr Lys Cys Thr Cys Arg 
    450                 


<210>  4405
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDI1__Homo_sapiens__NP_001484

<400>  4405

Met Asp Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu 
1               5                   10                  15      


Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His 
            20                  25                  30          


Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ser Ser Ile Thr Pro 
        35                  40                  45              


Leu Glu Glu Leu Tyr Lys Arg Phe Gln Leu Leu Glu Gly Pro Pro Glu 
    50                  55                  60                  


Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe 
65                  70                  75                  80  


Leu Met Ala Asn Gly Gln Leu Val Lys Met Leu Leu Tyr Thr Glu Val 
                85                  90                  95      


Thr Arg Tyr Leu Asp Phe Lys Val Val Glu Gly Ser Phe Val Tyr Lys 
            100                 105                 110         


Gly Gly Lys Ile Tyr Lys Val Pro Ser Thr Glu Thr Glu Ala Leu Ala 
        115                 120                 125             


Ser Asn Leu Met Gly Met Phe Glu Lys Arg Arg Phe Arg Lys Phe Leu 
    130                 135                 140                 


Val Phe Val Ala Asn Phe Asp Glu Asn Asp Pro Lys Thr Phe Glu Gly 
145                 150                 155                 160 


Val Asp Pro Gln Thr Thr Ser Met Arg Asp Val Tyr Arg Lys Phe Asp 
                165                 170                 175     


Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu Ala Leu Tyr 
            180                 185                 190         


Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Leu Glu Thr Val Asn Arg 
        195                 200                 205             


Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys Ser Pro Tyr 
    210                 215                 220                 


Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly Phe Ala Arg 
225                 230                 235                 240 


Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys Pro Val Asp 
                245                 250                 255     


Asp Ile Ile Met Glu Asn Gly Lys Val Val Gly Val Lys Ser Glu Gly 
            260                 265                 270         


Glu Val Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser Tyr Ile Pro 
        275                 280                 285             


Asp Arg Val Arg Lys Ala Gly Gln Val Ile Arg Ile Ile Cys Ile Leu 
    290                 295                 300                 


Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys Gln Ile Ile 
305                 310                 315                 320 


Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr Val Cys Met 
                325                 330                 335     


Ile Ser Tyr Ala His Asn Val Ala Ala Gln Gly Lys Tyr Ile Ala Ile 
            340                 345                 350         


Ala Ser Thr Thr Val Glu Thr Thr Asp Pro Glu Lys Glu Val Glu Pro 
        355                 360                 365             


Ala Leu Glu Leu Leu Glu Pro Ile Asp Gln Lys Phe Val Ala Ile Ser 
    370                 375                 380                 


Asp Leu Tyr Glu Pro Ile Asp Asp Gly Cys Glu Ser Gln Val Phe Cys 
385                 390                 395                 400 


Ser Cys Ser Tyr Asp Ala Thr Thr His Phe Glu Thr Thr Cys Asn Asp 
                405                 410                 415     


Ile Lys Asp Ile Tyr Lys Arg Met Ala Gly Thr Ala Phe Asp Phe Glu 
            420                 425                 430         


Asn Met Lys Arg Lys Gln Asn Asp Val Phe Gly Glu Ala Glu Gln 
        435                 440                 445         


<210>  4406
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDI2__Homo_sapiens__NP_001108628

<400>  4406

Met Asn Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu 
1               5                   10                  15      


Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His 
            20                  25                  30          


Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ala Ser Ile Thr Pro 
        35                  40                  45              


Leu Glu Asp Leu Tyr Lys Arg Phe Lys Ile Pro Gly Ser Pro Pro Glu 
    50                  55                  60                  


Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe 
65                  70                  75                  80  


Leu Met Ala Asn Gly Leu Met Gly Leu Phe Glu Lys Arg Arg Phe Arg 
                85                  90                  95      


Lys Phe Leu Val Tyr Val Ala Asn Phe Asp Glu Lys Asp Pro Arg Thr 
            100                 105                 110         


Phe Glu Gly Ile Asp Pro Lys Lys Thr Thr Met Arg Asp Val Tyr Lys 
        115                 120                 125             


Lys Phe Asp Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu 
    130                 135                 140                 


Ala Leu Tyr Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Tyr Glu Thr 
145                 150                 155                 160 


Ile Asn Arg Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys 
                165                 170                 175     


Ser Pro Tyr Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly 
            180                 185                 190         


Phe Ala Arg Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys 
        195                 200                 205             


Pro Ile Glu Glu Ile Ile Val Gln Asn Gly Lys Val Ile Gly Val Lys 
    210                 215                 220                 


Ser Glu Gly Glu Ile Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser 
225                 230                 235                 240 


Tyr Val Lys Asp Arg Val Glu Lys Val Gly Gln Val Ile Arg Val Ile 
                245                 250                 255     


Cys Ile Leu Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys 
            260                 265                 270         


Gln Ile Ile Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr 
        275                 280                 285             


Val Cys Met Ile Ser Phe Ala His Asn Val Ala Ala Gln Gly Lys Tyr 
    290                 295                 300                 


Ile Ala Ile Val Ser Thr Thr Val Glu Thr Lys Glu Pro Glu Lys Glu 
305                 310                 315                 320 


Ile Arg Pro Ala Leu Glu Leu Leu Glu Pro Ile Glu Gln Lys Phe Val 
                325                 330                 335     


Ser Ile Ser Asp Leu Leu Val Pro Lys Asp Leu Gly Thr Glu Ser Gln 
            340                 345                 350         


Ile Phe Ile Ser Arg Thr Tyr Asp Ala Thr Thr His Phe Glu Thr Thr 
        355                 360                 365             


Cys Asp Asp Ile Lys Asn Ile Tyr Lys Arg Met Thr Gly Ser Glu Phe 
    370                 375                 380                 


Asp Phe Glu Glu Met Lys Arg Lys Lys Asn Asp Ile Tyr Gly Glu Asp 
385                 390                 395                 400 


<210>  4407
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDNF__Homo_sapiens__NP_001177397

<400>  4407

Met Gln Ser Leu Pro Asn Ser Asn Gly Ala Ala Ala Gly Arg Asp Phe 
1               5                   10                  15      


Lys Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His 
            20                  25                  30          


Thr Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala 
        35                  40                  45              


Pro Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu 
    50                  55                  60                  


Ser Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp 
65                  70                  75                  80  


Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro 
                85                  90                  95      


Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala 
            100                 105                 110         


Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln 
        115                 120                 125             


Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val 
    130                 135                 140                 


Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg 
145                 150                 155                 160 


Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile 
                165                 170                 175     


Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly 
            180                 185                 190         


Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu 
        195                 200                 205             


Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg 
    210                 215                 220                 


Cys Gly Cys Ile 
225             


<210>  4408
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDPD3__Homo_sapiens__NP_077283

<400>  4408

Met Ser Leu Leu Leu Tyr Tyr Ala Leu Pro Ala Leu Gly Ser Tyr Ala 
1               5                   10                  15      


Met Leu Ser Ile Phe Phe Leu Arg Arg Pro His Leu Leu His Thr Pro 
            20                  25                  30          


Arg Ala Pro Thr Phe Arg Ile Arg Leu Gly Ala His Arg Gly Gly Ser 
        35                  40                  45              


Gly Glu Leu Leu Glu Asn Thr Met Glu Ala Met Glu Asn Ser Met Ala 
    50                  55                  60                  


Gln Arg Ser Asp Leu Leu Glu Leu Asp Cys Gln Leu Thr Arg Asp Arg 
65                  70                  75                  80  


Val Val Val Val Ser His Asp Glu Asn Leu Cys Arg Gln Ser Gly Leu 
                85                  90                  95      


Asn Arg Asp Val Gly Ser Leu Asp Phe Glu Asp Leu Pro Leu Tyr Lys 
            100                 105                 110         


Glu Lys Leu Glu Val Tyr Phe Ser Pro Gly His Phe Ala His Gly Ser 
        115                 120                 125             


Asp Arg Arg Met Val Arg Leu Glu Asp Leu Phe Gln Arg Phe Pro Arg 
    130                 135                 140                 


Thr Pro Met Ser Val Glu Ile Lys Gly Lys Asn Glu Glu Leu Ile Arg 
145                 150                 155                 160 


Glu Ile Ala Gly Leu Val Arg Arg Tyr Asp Arg Asn Glu Ile Thr Ile 
                165                 170                 175     


Trp Ala Ser Glu Lys Ser Ser Val Met Lys Lys Cys Lys Ala Ala Asn 
            180                 185                 190         


Pro Glu Met Pro Leu Ser Phe Thr Ile Ser Arg Gly Phe Trp Val Leu 
        195                 200                 205             


Leu Ser Tyr Tyr Leu Gly Leu Leu Pro Phe Ile Pro Ile Pro Glu Lys 
    210                 215                 220                 


Phe Phe Phe Cys Phe Leu Pro Asn Ile Ile Asn Arg Thr Tyr Phe Pro 
225                 230                 235                 240 


Phe Ser Cys Ser Cys Leu Asn Gln Leu Leu Ala Val Val Ser Lys Trp 
                245                 250                 255     


Leu Ile Met Arg Lys Ser Leu Ile Arg His Leu Glu Glu Arg Gly Val 
            260                 265                 270         


Gln Val Val Phe Trp Cys Leu Asn Glu Glu Ser Asp Phe Glu Ala Ala 
        275                 280                 285             


Phe Ser Val Gly Ala Thr Gly Val Ile Thr Asp Tyr Pro Thr Ala Leu 
    290                 295                 300                 


Arg His Tyr Leu Asp Asn His Gly Pro Ala Ala Arg Thr Ser 
305                 310                 315             


<210>  4409
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDPD5__Homo_sapiens__NP_110419

<400>  4409

Met Val Arg His Gln Pro Leu Gln Tyr Tyr Glu Pro Gln Leu Cys Leu 
1               5                   10                  15      


Ser Cys Leu Thr Gly Ile Tyr Gly Cys Arg Trp Lys Arg Tyr Gln Arg 
            20                  25                  30          


Ser His Asp Asp Thr Thr Pro Trp Glu Arg Leu Trp Phe Leu Leu Leu 
        35                  40                  45              


Thr Phe Thr Phe Gly Leu Thr Leu Thr Trp Leu Tyr Phe Trp Trp Glu 
    50                  55                  60                  


Val His Asn Asp Tyr Asp Glu Phe Asn Trp Tyr Leu Tyr Asn Arg Met 
65                  70                  75                  80  


Gly Tyr Trp Ser Asp Trp Pro Val Pro Ile Leu Val Thr Thr Ala Ala 
                85                  90                  95      


Ala Phe Ala Tyr Ile Ala Gly Leu Leu Val Leu Ala Leu Cys His Ile 
            100                 105                 110         


Ala Val Gly Gln Gln Met Asn Leu His Trp Leu His Lys Ile Gly Leu 
        115                 120                 125             


Val Val Ile Leu Ala Ser Thr Val Val Ala Met Ser Ala Val Ala Gln 
    130                 135                 140                 


Leu Trp Glu Asp Glu Trp Glu Val Leu Leu Ile Ser Leu Gln Gly Thr 
145                 150                 155                 160 


Ala Pro Phe Leu His Val Gly Ala Val Ala Ala Val Thr Met Leu Ser 
                165                 170                 175     


Trp Ile Val Ala Gly Gln Phe Ala Arg Ala Glu Arg Thr Ser Ser Gln 
            180                 185                 190         


Val Thr Ile Leu Cys Thr Phe Phe Thr Val Val Phe Ala Leu Tyr Leu 
        195                 200                 205             


Ala Pro Leu Thr Ile Ser Ser Pro Cys Ile Met Glu Lys Lys Asp Leu 
    210                 215                 220                 


Gly Pro Lys Pro Ala Leu Ile Gly His Arg Gly Ala Pro Met Leu Ala 
225                 230                 235                 240 


Pro Glu His Thr Leu Met Ser Phe Arg Lys Ala Leu Glu Gln Lys Leu 
                245                 250                 255     


Tyr Gly Leu Gln Ala Asp Ile Thr Ile Ser Leu Asp Gly Val Pro Phe 
            260                 265                 270         


Leu Met His Asp Thr Thr Leu Arg Arg Thr Thr Asn Val Glu Glu Glu 
        275                 280                 285             


Phe Pro Glu Leu Ala Arg Arg Pro Ala Ser Met Leu Asn Trp Thr Thr 
    290                 295                 300                 


Leu Gln Arg Leu Asn Ala Gly Gln Trp Phe Leu Lys Thr Asp Pro Phe 
305                 310                 315                 320 


Trp Thr Ala Ser Ser Leu Ser Pro Ser Asp His Arg Glu Ala Gln Asn 
                325                 330                 335     


Gln Ser Ile Cys Ser Leu Ala Glu Leu Leu Glu Leu Ala Lys Gly Asn 
            340                 345                 350         


Ala Thr Leu Leu Leu Asn Leu Arg Asp Pro Pro Arg Glu His Pro Tyr 
        355                 360                 365             


Arg Ser Ser Phe Ile Asn Val Thr Leu Glu Ala Val Leu His Ser Gly 
    370                 375                 380                 


Phe Pro Gln His Gln Val Met Trp Leu Pro Ser Arg Gln Arg Pro Leu 
385                 390                 395                 400 


Val Arg Lys Val Ala Pro Gly Phe Gln Gln Thr Ser Gly Ser Lys Glu 
                405                 410                 415     


Ala Val Ala Ser Leu Arg Arg Gly His Ile Gln Arg Leu Asn Leu Arg 
            420                 425                 430         


Tyr Thr Gln Val Ser Arg Gln Glu Leu Arg Asp Tyr Ala Ser Trp Asn 
        435                 440                 445             


Leu Ser Val Asn Leu Tyr Thr Val Asn Ala Pro Trp Leu Phe Ser Leu 
    450                 455                 460                 


Leu Trp Cys Ala Gly Val Pro Ser Val Thr Ser Asp Asn Ser His Ala 
465                 470                 475                 480 


Leu Ser Gln Val Pro Ser Pro Leu Trp Ile Met Pro Pro Asp Glu Tyr 
                485                 490                 495     


Cys Leu Met Trp Val Thr Ala Asp Leu Val Ser Phe Thr Leu Ile Val 
            500                 505                 510         


Gly Ile Phe Val Leu Gln Lys Trp Arg Leu Gly Gly Ile Arg Ser Tyr 
        515                 520                 525             


Asn Pro Glu Gln Ile Met Leu Ser Ala Ala Val Arg Arg Thr Ser Arg 
    530                 535                 540                 


Asp Val Ser Ile Met Lys Glu Lys Leu Ile Phe Ser Glu Ile Ser Asp 
545                 550                 555                 560 


Gly Val Glu Val Ser Asp Val Leu Ser Val Cys Ser Asp Asn Ser Tyr 
                565                 570                 575     


Asp Thr Tyr Ala Asn Ser Thr Ala Thr Pro Val Gly Pro Arg Gly Gly 
            580                 585                 590         


Gly Ser His Thr Lys Thr Leu Ile Glu Arg Ser Gly Arg 
        595                 600                 605 


<210>  4410
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEM__Homo_sapiens__NP_859053

<400>  4410

Met Thr Leu Asn Asn Val Thr Met Arg Gln Gly Thr Val Gly Met Gln 
1               5                   10                  15      


Pro Gln Gln Gln Arg Trp Ser Ile Pro Ala Asp Gly Arg His Leu Met 
            20                  25                  30          


Val Gln Lys Glu Pro His Gln Tyr Ser His Arg Asn Arg His Ser Ala 
        35                  40                  45              


Thr Pro Glu Asp His Cys Arg Arg Ser Trp Ser Ser Asp Ser Thr Asp 
    50                  55                  60                  


Ser Val Ile Ser Ser Glu Ser Gly Asn Thr Tyr Tyr Arg Val Val Leu 
65                  70                  75                  80  


Ile Gly Glu Gln Gly Val Gly Lys Ser Thr Leu Ala Asn Ile Phe Ala 
                85                  90                  95      


Gly Val His Asp Ser Met Asp Ser Asp Cys Glu Val Leu Gly Glu Asp 
            100                 105                 110         


Thr Tyr Glu Arg Thr Leu Met Val Asp Gly Glu Ser Ala Thr Ile Ile 
        115                 120                 125             


Leu Leu Asp Met Trp Glu Asn Lys Gly Glu Asn Glu Trp Leu His Asp 
    130                 135                 140                 


His Cys Met Gln Val Gly Asp Ala Tyr Leu Ile Val Tyr Ser Ile Thr 
145                 150                 155                 160 


Asp Arg Ala Ser Phe Glu Lys Ala Ser Glu Leu Arg Ile Gln Leu Arg 
                165                 170                 175     


Arg Ala Arg Gln Thr Glu Asp Ile Pro Ile Ile Leu Val Gly Asn Lys 
            180                 185                 190         


Ser Asp Leu Val Arg Cys Arg Glu Val Ser Val Ser Glu Gly Arg Ala 
        195                 200                 205             


Cys Ala Val Val Phe Asp Cys Lys Phe Ile Glu Thr Ser Ala Ala Val 
    210                 215                 220                 


Gln His Asn Val Lys Glu Leu Phe Glu Gly Ile Val Arg Gln Val Arg 
225                 230                 235                 240 


Leu Arg Arg Asp Ser Lys Glu Lys Asn Glu Arg Arg Leu Ala Tyr Gln 
                245                 250                 255     


Lys Arg Lys Glu Ser Met Pro Arg Lys Ala Arg Arg Phe Trp Gly Lys 
            260                 265                 270         


Ile Val Ala Lys Asn Asn Lys Asn Met Ala Phe Lys Leu Lys Ser Lys 
        275                 280                 285             


Ser Cys His Asp Leu Ser Val Leu 
    290                 295     


<210>  4411
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEMIN2__Homo_sapiens__NP_001009182

<400>  4411

Met Arg Arg Ala Glu Leu Ala Gly Leu Lys Thr Met Ala Trp Val Pro 
1               5                   10                  15      


Ala Glu Ser Ala Val Glu Glu Leu Met Pro Arg Leu Leu Pro Val Glu 
            20                  25                  30          


Pro Cys Asp Leu Thr Glu Gly Phe Asp Pro Ser Val Pro Pro Arg Thr 
        35                  40                  45              


Pro Gln Glu Tyr Leu Arg Arg Val Gln Ile Glu Ala Ala Gln Cys Pro 
    50                  55                  60                  


Asp Val Val Val Ala Gln Ile Asp Pro Lys Lys Leu Lys Arg Lys Gln 
65                  70                  75                  80  


Ser Val Asn Ile Ser Leu Ser Gly Cys Gln Pro Ala Pro Glu Gly Tyr 
                85                  90                  95      


Ser Pro Thr Leu Gln Trp Gln Gln Gln Gln Val Ala Gln Phe Ser Thr 
            100                 105                 110         


Val Arg Gln Asn Val Asn Lys His Arg Ser His Trp Lys Ser Gln Gln 
        115                 120                 125             


Leu Asp Ser Asn Val Thr Met Pro Lys Ser Glu Asp Glu Glu Gly Trp 
    130                 135                 140                 


Lys Lys Phe Cys Leu Gly Glu Lys Leu Cys Ala Asp Gly Ala Val Gly 
145                 150                 155                 160 


Pro Ala Thr Asn Glu Ser Pro Gly Ile Asp Tyr Val Gln Ala Thr Val 
                165                 170                 175     


Thr Ser Val Leu Glu Tyr Leu Ser Asn Trp Phe Gly Glu Arg Asp Phe 
            180                 185                 190         


Thr Pro Glu Leu Gly Arg Trp Leu Tyr Ala Leu Leu Ala Cys Leu Glu 
        195                 200                 205             


Lys Pro Leu Leu Pro Glu Ala His Ser Leu Ile Arg Gln Leu Ala Arg 
    210                 215                 220                 


Arg Cys Ser Glu Val Arg Leu Leu Val Asp Ser Lys Asp Asp Glu Arg 
225                 230                 235                 240 


Val Pro Ala Leu Asn Leu Leu Ile Cys Leu Val Ser Arg Tyr Phe Asp 
                245                 250                 255     


Gln Arg Asp Leu Ala Asp Glu Pro Ser 
            260                 265 


<210>  4412
<211>  1058
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEMIN4__Homo_sapiens__NP_056536

<400>  4412

Met Asp Leu Gly Pro Leu Asn Ile Cys Glu Glu Met Thr Ile Leu His 
1               5                   10                  15      


Gly Gly Phe Leu Leu Ala Glu Gln Leu Phe His Pro Lys Ala Leu Ala 
            20                  25                  30          


Glu Leu Thr Lys Ser Asp Trp Glu Arg Val Gly Arg Pro Ile Val Glu 
        35                  40                  45              


Ala Leu Arg Glu Ile Ser Ser Ala Ala Ala His Ser Gln Pro Phe Ala 
    50                  55                  60                  


Trp Lys Lys Lys Ala Leu Ile Ile Ile Trp Ala Lys Val Leu Gln Pro 
65                  70                  75                  80  


His Pro Val Thr Pro Ser Asp Thr Glu Thr Arg Trp Gln Glu Asp Leu 
                85                  90                  95      


Phe Phe Ser Val Gly Asn Met Ile Pro Thr Ile Asn His Thr Ile Leu 
            100                 105                 110         


Phe Glu Leu Leu Lys Ser Leu Glu Ala Ser Gly Leu Phe Ile Gln Leu 
        115                 120                 125             


Leu Met Ala Leu Pro Thr Thr Ile Cys His Ala Glu Leu Glu Arg Phe 
    130                 135                 140                 


Leu Glu His Val Thr Val Asp Thr Ser Ala Glu Asp Val Ala Phe Phe 
145                 150                 155                 160 


Leu Asp Val Trp Trp Glu Val Met Lys His Lys Gly His Pro Gln Asp 
                165                 170                 175     


Pro Leu Leu Ser Gln Phe Ser Ala Met Ala His Lys Tyr Leu Pro Ala 
            180                 185                 190         


Leu Asp Glu Phe Pro His Pro Pro Lys Arg Leu Arg Ser Asp Pro Asp 
        195                 200                 205             


Ala Cys Pro Thr Met Pro Leu Leu Ala Met Leu Leu Arg Gly Leu Thr 
    210                 215                 220                 


Gln Ile Gln Ser Arg Ile Leu Gly Pro Gly Arg Lys Cys Cys Ala Leu 
225                 230                 235                 240 


Ala Asn Leu Ala Asp Met Leu Thr Val Phe Ala Leu Thr Glu Asp Asp 
                245                 250                 255     


Pro Gln Glu Val Ser Ala Thr Val Tyr Leu Asp Lys Leu Ala Thr Val 
            260                 265                 270         


Ile Ser Val Trp Asn Ser Asp Thr Gln Asn Pro Tyr His Gln Gln Ala 
        275                 280                 285             


Leu Ala Glu Lys Val Lys Glu Ala Glu Arg Asp Val Ser Leu Thr Ser 
    290                 295                 300                 


Leu Ala Lys Leu Pro Ser Glu Thr Ile Phe Val Gly Cys Glu Phe Leu 
305                 310                 315                 320 


His His Leu Leu Arg Glu Trp Gly Glu Glu Leu Gln Ala Val Leu Arg 
                325                 330                 335     


Ser Ser Gln Gly Thr Ser Tyr Asp Ser Tyr Arg Leu Cys Asp Ser Leu 
            340                 345                 350         


Thr Ser Phe Ser Gln Asn Ala Thr Leu Tyr Leu Asn Arg Thr Ser Leu 
        355                 360                 365             


Ser Lys Glu Asp Arg Gln Val Val Ser Glu Leu Ala Glu Cys Val Arg 
    370                 375                 380                 


Asp Phe Leu Arg Lys Thr Ser Thr Val Leu Lys Asn Arg Ala Leu Glu 
385                 390                 395                 400 


Asp Ile Thr Ala Ser Ile Ala Met Ala Val Ile Gln Gln Lys Met Asp 
                405                 410                 415     


Arg His Met Glu Val Cys Tyr Ile Phe Ala Ser Glu Lys Lys Trp Ala 
            420                 425                 430         


Phe Ser Asp Glu Trp Val Ala Cys Leu Gly Ser Asn Arg Ala Leu Phe 
        435                 440                 445             


Arg Gln Pro Asp Leu Val Leu Arg Leu Leu Glu Thr Val Ile Asp Val 
    450                 455                 460                 


Ser Thr Ala Asp Arg Ala Ile Pro Glu Ser Gln Ile Arg Gln Val Ile 
465                 470                 475                 480 


His Leu Ile Leu Glu Cys Tyr Ala Asp Leu Ser Leu Pro Gly Lys Asn 
                485                 490                 495     


Lys Val Leu Ala Gly Ile Leu Arg Ser Trp Gly Arg Lys Gly Leu Ser 
            500                 505                 510         


Glu Lys Leu Leu Ala Tyr Val Glu Gly Phe Gln Glu Asp Leu Asn Thr 
        515                 520                 525             


Thr Phe Asn Gln Leu Thr Gln Ser Ala Ser Glu Gln Gly Leu Ala Lys 
    530                 535                 540                 


Ala Val Ala Ser Val Ala Arg Leu Val Ile Val His Pro Glu Val Thr 
545                 550                 555                 560 


Val Lys Lys Met Cys Ser Leu Ala Val Val Asn Leu Gly Thr His Lys 
                565                 570                 575     


Phe Leu Ala Gln Ile Leu Thr Ala Phe Pro Ala Leu Arg Phe Val Glu 
            580                 585                 590         


Glu Gln Gly Pro Asn Ser Ser Ala Thr Phe Met Val Ser Cys Leu Lys 
        595                 600                 605             


Glu Thr Val Trp Met Lys Phe Ser Thr Pro Lys Glu Glu Lys Gln Phe 
    610                 615                 620                 


Leu Glu Leu Leu Asn Cys Leu Met Ser Pro Val Lys Pro Gln Gly Ile 
625                 630                 635                 640 


Pro Val Ala Ala Leu Leu Glu Pro Asp Glu Val Leu Lys Glu Phe Val 
                645                 650                 655     


Leu Pro Phe Leu Arg Leu Asp Val Glu Glu Val Asp Leu Ser Leu Arg 
            660                 665                 670         


Ile Phe Ile Gln Thr Leu Glu Ala Asn Ala Cys Arg Glu Glu Tyr Trp 
        675                 680                 685             


Leu Gln Thr Cys Ser Pro Phe Pro Leu Leu Phe Ser Leu Cys Gln Leu 
    690                 695                 700                 


Leu Asp Arg Phe Ser Lys Tyr Trp Gln Leu Pro Lys Glu Lys Arg Cys 
705                 710                 715                 720 


Leu Ser Leu Asp Arg Lys Asp Leu Ala Ile His Ile Leu Glu Leu Leu 
                725                 730                 735     


Cys Glu Ile Val Ser Ala Asn Ala Glu Thr Phe Ser Pro Asp Val Trp 
            740                 745                 750         


Ile Lys Ser Leu Ser Trp Leu His Arg Lys Leu Glu Gln Leu Asp Trp 
        755                 760                 765             


Thr Val Gly Leu Arg Leu Lys Ser Phe Phe Glu Gly His Phe Lys Cys 
    770                 775                 780                 


Glu Val Pro Ala Thr Leu Phe Glu Ile Cys Lys Leu Ser Glu Asp Glu 
785                 790                 795                 800 


Trp Thr Ser Gln Ala His Pro Gly Tyr Gly Ala Gly Thr Gly Leu Leu 
                805                 810                 815     


Ala Trp Met Glu Cys Cys Cys Val Ser Ser Gly Ile Ser Glu Arg Met 
            820                 825                 830         


Leu Ser Leu Leu Val Val Asp Val Gly Asn Pro Glu Glu Val Arg Leu 
        835                 840                 845             


Phe Ser Lys Gly Phe Leu Val Ala Leu Val Gln Val Met Pro Trp Cys 
    850                 855                 860                 


Ser Pro Gln Glu Trp Gln Arg Leu His Gln Leu Thr Arg Arg Leu Leu 
865                 870                 875                 880 


Glu Lys Gln Leu Leu His Val Pro Tyr Ser Leu Glu Tyr Ile Gln Phe 
                885                 890                 895     


Val Pro Leu Leu Asn Leu Lys Pro Phe Ala Gln Glu Leu Gln Leu Ser 
            900                 905                 910         


Val Leu Phe Leu Arg Thr Phe Gln Phe Leu Cys Ser His Ser Cys Arg 
        915                 920                 925             


Asp Trp Leu Pro Leu Glu Gly Trp Asn His Val Val Lys Leu Leu Cys 
    930                 935                 940                 


Gly Ser Leu Thr Arg Leu Leu Asp Ser Val Arg Ala Ile Gln Ala Ala 
945                 950                 955                 960 


Gly Pro Trp Val Gln Gly Pro Glu Gln Asp Leu Thr Gln Glu Ala Leu 
                965                 970                 975     


Phe Val Tyr Thr Gln Val Phe Cys His Ala Leu His Ile Met Ala Met 
            980                 985                 990         


Leu His Pro Glu Val Cys Glu Pro  Leu Tyr Val Leu Ala  Leu Glu Thr 
        995                 1000                 1005             


Leu Thr  Cys Tyr Glu Thr Leu  Ser Lys Thr Asn Pro  Ser Val Ser 
    1010                 1015                 1020             


Ser Leu  Leu Gln Arg Ala His  Glu Gln Arg Phe Leu  Lys Ser Ile 
    1025                 1030                 1035             


Ala Glu  Gly Ile Gly Pro Glu  Glu Arg Arg Gln Thr  Leu Leu Gln 
    1040                 1045                 1050             


Lys Met  Ser Ser Phe 
    1055             


<210>  4413
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEMIN6__Homo_sapiens__NP_079051

<400>  4413

Met Ser Glu Trp Met Lys Lys Gly Pro Leu Glu Trp Gln Asp Tyr Ile 
1               5                   10                  15      


Tyr Lys Glu Val Arg Val Thr Ala Ser Glu Lys Asn Glu Tyr Lys Gly 
            20                  25                  30          


Trp Val Leu Thr Thr Asp Pro Val Ser Ala Asn Ile Val Leu Val Asn 
        35                  40                  45              


Phe Leu Glu Asp Gly Ser Met Ser Val Thr Gly Ile Met Gly His Ala 
    50                  55                  60                  


Val Gln Thr Val Glu Thr Met Asn Glu Gly Asp His Arg Val Arg Glu 
65                  70                  75                  80  


Lys Leu Met His Leu Phe Thr Ser Gly Asp Cys Lys Ala Tyr Ser Pro 
                85                  90                  95      


Glu Asp Leu Glu Glu Arg Lys Asn Ser Leu Lys Lys Trp Leu Glu Lys 
            100                 105                 110         


Asn His Ile Pro Ile Thr Glu Gln Gly Asp Ala Pro Arg Thr Leu Cys 
        115                 120                 125             


Val Ala Gly Val Leu Thr Ile Asp Pro Pro Tyr Gly Pro Glu Asn Cys 
    130                 135                 140                 


Ser Ser Ser Asn Glu Ile Ile Leu Ser Arg Val Gln Asp Leu Ile Glu 
145                 150                 155                 160 


Gly His Leu Thr Ala Ser Gln 
                165         


<210>  4414
<211>  908
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEN1__Homo_sapiens__NP_872431

<400>  4414

Met Gly Val Asn Asp Leu Trp Gln Ile Leu Glu Pro Val Lys Gln His 
1               5                   10                  15      


Ile Pro Leu Arg Asn Leu Gly Gly Lys Thr Ile Ala Val Asp Leu Ser 
            20                  25                  30          


Leu Trp Val Cys Glu Ala Gln Thr Val Lys Lys Met Met Gly Ser Val 
        35                  40                  45              


Met Lys Pro His Leu Arg Asn Leu Phe Phe Arg Ile Ser Tyr Leu Thr 
    50                  55                  60                  


Gln Met Asp Val Lys Leu Val Phe Val Met Glu Gly Glu Pro Pro Lys 
65                  70                  75                  80  


Leu Lys Ala Asp Val Ile Ser Lys Arg Asn Gln Ser Arg Tyr Gly Ser 
                85                  90                  95      


Ser Gly Lys Ser Trp Ser Gln Lys Thr Gly Arg Ser His Phe Lys Ser 
            100                 105                 110         


Val Leu Arg Glu Cys Leu His Met Leu Glu Cys Leu Gly Ile Pro Trp 
        115                 120                 125             


Val Gln Ala Ala Gly Glu Ala Glu Ala Met Cys Ala Tyr Leu Asn Ala 
    130                 135                 140                 


Gly Gly His Val Asp Gly Cys Leu Thr Asn Asp Gly Asp Thr Phe Leu 
145                 150                 155                 160 


Tyr Gly Ala Gln Thr Val Tyr Arg Asn Phe Thr Met Asn Thr Lys Asp 
                165                 170                 175     


Pro His Val Asp Cys Tyr Thr Met Ser Ser Ile Lys Ser Lys Leu Gly 
            180                 185                 190         


Leu Asp Arg Asp Ala Leu Val Gly Leu Ala Ile Leu Leu Gly Cys Asp 
        195                 200                 205             


Tyr Leu Pro Lys Gly Val Pro Gly Val Gly Lys Glu Gln Ala Leu Lys 
    210                 215                 220                 


Leu Ile Gln Ile Leu Lys Gly Gln Ser Leu Leu Gln Arg Phe Asn Arg 
225                 230                 235                 240 


Trp Asn Glu Thr Ser Cys Asn Ser Ser Pro Gln Leu Leu Val Thr Lys 
                245                 250                 255     


Lys Leu Ala His Cys Ser Val Cys Ser His Pro Gly Ser Pro Lys Asp 
            260                 265                 270         


His Glu Arg Asn Gly Cys Arg Leu Cys Lys Ser Asp Lys Tyr Cys Glu 
        275                 280                 285             


Pro His Asp Tyr Glu Tyr Cys Cys Pro Cys Glu Trp His Arg Thr Glu 
    290                 295                 300                 


His Asp Arg Gln Leu Asn Glu Val Glu Asn Asn Ile Lys Lys Lys Ala 
305                 310                 315                 320 


Cys Cys Cys Glu Gly Phe Pro Phe His Glu Val Ile Gln Glu Phe Leu 
                325                 330                 335     


Leu Asn Lys Asp Lys Leu Val Lys Val Ile Arg Tyr Gln Arg Pro Asp 
            340                 345                 350         


Leu Leu Leu Phe Gln Arg Phe Thr Leu Glu Lys Met Glu Trp Pro Asn 
        355                 360                 365             


His Tyr Ala Cys Glu Lys Leu Leu Val Leu Leu Thr His Tyr Asp Met 
    370                 375                 380                 


Ile Glu Arg Lys Leu Gly Ser Arg Asn Ser Asn Gln Leu Gln Pro Ile 
385                 390                 395                 400 


Arg Ile Val Lys Thr Arg Ile Arg Asn Gly Val His Cys Phe Glu Ile 
                405                 410                 415     


Glu Trp Glu Lys Pro Glu His Tyr Ala Met Glu Asp Lys Gln His Gly 
            420                 425                 430         


Glu Phe Ala Leu Leu Thr Ile Glu Glu Glu Ser Leu Phe Glu Ala Ala 
        435                 440                 445             


Tyr Pro Glu Ile Val Ala Val Tyr Gln Lys Gln Lys Leu Glu Ile Lys 
    450                 455                 460                 


Gly Lys Lys Gln Lys Arg Ile Lys Pro Lys Glu Asn Asn Leu Pro Glu 
465                 470                 475                 480 


Pro Asp Glu Val Met Ser Phe Gln Ser His Met Thr Leu Lys Pro Thr 
                485                 490                 495     


Cys Glu Ile Phe His Lys Gln Asn Ser Lys Leu Asn Ser Gly Ile Ser 
            500                 505                 510         


Pro Asp Pro Thr Leu Pro Gln Glu Ser Ile Ser Ala Ser Leu Asn Ser 
        515                 520                 525             


Leu Leu Leu Pro Lys Asn Thr Pro Cys Leu Asn Ala Gln Glu Gln Phe 
    530                 535                 540                 


Met Ser Ser Leu Arg Pro Leu Ala Ile Gln Gln Ile Lys Ala Val Ser 
545                 550                 555                 560 


Lys Ser Leu Ile Ser Glu Ser Ser Gln Pro Asn Thr Ser Ser His Asn 
                565                 570                 575     


Ile Ser Val Ile Ala Asp Leu His Leu Ser Thr Ile Asp Trp Glu Gly 
            580                 585                 590         


Thr Ser Phe Ser Asn Ser Pro Ala Ile Gln Arg Asn Thr Phe Ser His 
        595                 600                 605             


Asp Leu Lys Ser Glu Val Glu Ser Glu Leu Ser Ala Ile Pro Asp Gly 
    610                 615                 620                 


Phe Glu Asn Ile Pro Glu Gln Leu Ser Cys Glu Ser Glu Arg Tyr Thr 
625                 630                 635                 640 


Ala Asn Ile Lys Lys Val Leu Asp Glu Asp Ser Asp Gly Ile Ser Pro 
                645                 650                 655     


Glu Glu His Leu Leu Ser Gly Ile Thr Asp Leu Cys Leu Gln Asp Leu 
            660                 665                 670         


Pro Leu Lys Glu Arg Ile Phe Thr Lys Leu Ser Tyr Pro Gln Asp Asn 
        675                 680                 685             


Leu Gln Pro Asp Val Asn Leu Lys Thr Leu Ser Ile Leu Ser Val Lys 
    690                 695                 700                 


Glu Ser Cys Ile Ala Asn Ser Gly Ser Asp Cys Thr Ser His Leu Ser 
705                 710                 715                 720 


Lys Asp Leu Pro Gly Ile Pro Leu Gln Asn Glu Ser Arg Asp Ser Lys 
                725                 730                 735     


Ile Leu Lys Gly Asp Gln Leu Leu Gln Glu Asp Tyr Lys Val Asn Thr 
            740                 745                 750         


Ser Val Pro Tyr Ser Val Ser Asn Thr Val Val Lys Thr Cys Asn Val 
        755                 760                 765             


Arg Pro Pro Asn Thr Ala Leu Asp His Ser Arg Lys Val Asp Met Gln 
    770                 775                 780                 


Thr Thr Arg Lys Ile Leu Met Lys Lys Ser Val Cys Leu Asp Arg His 
785                 790                 795                 800 


Ser Ser Asp Glu Gln Ser Ala Pro Val Phe Gly Lys Ala Lys Tyr Thr 
                805                 810                 815     


Thr Gln Arg Met Lys His Ser Ser Gln Lys His Asn Ser Ser His Phe 
            820                 825                 830         


Lys Glu Ser Gly His Asn Lys Leu Ser Ser Pro Lys Ile His Ile Lys 
        835                 840                 845             


Glu Thr Glu Gln Cys Val Arg Ser Tyr Glu Thr Ala Glu Asn Glu Glu 
    850                 855                 860                 


Ser Cys Phe Pro Asp Ser Thr Lys Ser Ser Leu Ser Ser Leu Gln Cys 
865                 870                 875                 880 


His Lys Lys Glu Asn Asn Ser Gly Thr Cys Leu Asp Ser Pro Leu Pro 
                885                 890                 895     


Leu Arg Gln Arg Leu Lys Leu Arg Phe Gln Ser Thr 
            900                 905             


<210>  4415
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GET4__Homo_sapiens__NP_057033

<400>  4415

Met Ala Ala Ala Ala Ala Met Ala Glu Gln Glu Ser Ala Arg Asn Gly 
1               5                   10                  15      


Gly Arg Asn Arg Gly Gly Val Gln Arg Val Glu Gly Lys Leu Arg Ala 
            20                  25                  30          


Ser Val Glu Lys Gly Asp Tyr Tyr Glu Ala His Gln Met Tyr Arg Thr 
        35                  40                  45              


Leu Phe Phe Arg Tyr Met Ser Gln Ser Lys His Thr Glu Ala Arg Glu 
    50                  55                  60                  


Leu Met Tyr Ser Gly Ala Leu Leu Phe Phe Ser His Gly Gln Gln Asn 
65                  70                  75                  80  


Ser Ala Ala Asp Leu Ser Met Leu Val Leu Glu Ser Leu Glu Lys Ala 
                85                  90                  95      


Glu Val Glu Val Ala Asp Glu Leu Leu Glu Asn Leu Ala Lys Val Phe 
            100                 105                 110         


Ser Leu Met Asp Pro Asn Ser Pro Glu Arg Val Thr Phe Val Ser Arg 
        115                 120                 125             


Ala Leu Lys Trp Ser Ser Gly Gly Ser Gly Lys Leu Gly His Pro Arg 
    130                 135                 140                 


Leu His Gln Leu Leu Ala Leu Thr Leu Trp Lys Glu Gln Asn Tyr Cys 
145                 150                 155                 160 


Glu Ser Arg Tyr His Phe Leu His Ser Ala Asp Gly Glu Gly Cys Ala 
                165                 170                 175     


Asn Met Leu Val Glu Tyr Ser Thr Ser Arg Gly Phe Arg Ser Glu Val 
            180                 185                 190         


Asp Met Phe Val Ala Gln Ala Val Leu Gln Phe Leu Cys Leu Lys Asn 
        195                 200                 205             


Lys Ser Ser Ala Ser Val Val Phe Thr Thr Tyr Thr Gln Lys His Pro 
    210                 215                 220                 


Ser Ile Glu Asp Gly Pro Pro Phe Val Glu Pro Leu Leu Asn Phe Ile 
225                 230                 235                 240 


Trp Phe Leu Leu Leu Ala Val Asp Gly Gly Lys Leu Thr Val Phe Thr 
                245                 250                 255     


Val Leu Cys Glu Gln Tyr Gln Pro Ser Leu Arg Arg Asp Pro Met Tyr 
            260                 265                 270         


Asn Glu Tyr Leu Asp Arg Ile Gly Gln Leu Phe Phe Gly Val Pro Pro 
        275                 280                 285             


Lys Gln Thr Ser Ser Tyr Gly Gly Leu Leu Gly Asn Leu Leu Thr Ser 
    290                 295                 300                 


Leu Met Gly Ser Ser Glu Gln Glu Asp Gly Glu Glu Ser Pro Ser Asp 
305                 310                 315                 320 


Gly Ser Pro Ile Glu Leu Asp 
                325         


<210>  4416
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFAP__Homo_sapiens__NP_001124491

<400>  4416

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Gly Gly Lys Ser Thr Lys Asp Gly Glu Asn 
385                 390                 395                 400 


His Lys Val Thr Arg Tyr Leu Lys Ser Leu Thr Ile Arg Val Ile Pro 
                405                 410                 415     


Ile Gln Ala His Gln Ile Val Asn Gly Thr Pro Pro Ala Arg Gly 
            420                 425                 430     


<210>  4417
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFER__Homo_sapiens__NP_005253

<400>  4417

Met Ala Ala Pro Gly Glu Arg Gly Arg Phe His Gly Gly Asn Leu Phe 
1               5                   10                  15      


Phe Leu Pro Gly Gly Ala Arg Ser Glu Met Met Asp Asp Leu Ala Thr 
            20                  25                  30          


Asp Ala Arg Gly Arg Gly Ala Gly Arg Arg Asp Ala Ala Ala Ser Ala 
        35                  40                  45              


Ser Thr Pro Ala Gln Ala Pro Thr Ser Asp Ser Pro Val Ala Glu Asp 
    50                  55                  60                  


Ala Ser Arg Arg Arg Pro Cys Arg Ala Cys Val Asp Phe Lys Thr Trp 
65                  70                  75                  80  


Met Arg Thr Gln Gln Lys Arg Asp Thr Lys Phe Arg Glu Asp Cys Pro 
                85                  90                  95      


Pro Asp Arg Glu Glu Leu Gly Arg His Ser Trp Ala Val Leu His Thr 
            100                 105                 110         


Leu Ala Ala Tyr Tyr Pro Asp Leu Pro Thr Pro Glu Gln Gln Gln Asp 
        115                 120                 125             


Met Ala Gln Phe Ile His Leu Phe Ser Lys Phe Tyr Pro Cys Glu Glu 
    130                 135                 140                 


Cys Ala Glu Asp Leu Arg Lys Arg Leu Cys Arg Asn His Pro Asp Thr 
145                 150                 155                 160 


Arg Thr Arg Ala Cys Phe Thr Gln Trp Leu Cys His Leu His Asn Glu 
                165                 170                 175     


Val Asn Arg Lys Leu Gly Lys Pro Asp Phe Asp Cys Ser Lys Val Asp 
            180                 185                 190         


Glu Arg Trp Arg Asp Gly Trp Lys Asp Gly Ser Cys Asp 
        195                 200                 205 


<210>  4418
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFI1B__Homo_sapiens__NP_001128503

<400>  4418

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Thr Tyr His 
1               5                   10                  15      


Gln Pro Arg Val Gln Glu Asp Glu Pro Leu Trp Pro Pro Ala Leu Thr 
            20                  25                  30          


Pro Val Pro Arg Asp Gln Ala Pro Ser Asn Ser Pro Val Leu Ser Thr 
        35                  40                  45              


Leu Phe Pro Asn Gln Cys Leu Asp Trp Thr Asn Leu Lys Arg Glu Pro 
    50                  55                  60                  


Glu Leu Glu Gln Asp Gln Asn Leu Ala Arg Met Ala Pro Ala Pro Glu 
65                  70                  75                  80  


Gly Pro Ile Val Leu Ser Arg Pro Gln Asp Gly Asp Ser Pro Leu Ser 
                85                  90                  95      


Asp Ser Pro Pro Phe Tyr Lys Pro Ser Phe Ser Trp Asp Thr Leu Ala 
            100                 105                 110         


Thr Thr Tyr Gly His Ser Tyr Arg Gln Ala Pro Ser Thr Met Gln Ser 
        115                 120                 125             


Ala Phe Leu Glu His Ser Val Ser Leu Tyr Gly Ser Pro Leu Val Pro 
    130                 135                 140                 


Ser Thr Glu Pro Ala Leu Asp Phe Ser Leu Arg Tyr Ser Pro Gly Met 
145                 150                 155                 160 


Asp Ala Tyr His Cys Val Lys Cys Asn Lys Glu Arg Ser Phe Glu Cys 
                165                 170                 175     


Arg Met Cys Gly Lys Ala Phe Lys Arg Ser Ser Thr Leu Ser Thr His 
            180                 185                 190         


Leu Leu Ile His Ser Asp Thr Arg Pro Tyr Pro Cys Gln Phe Cys Gly 
        195                 200                 205             


Lys Arg Phe His Gln Lys Ser Asp Met Lys Lys His Thr Tyr Ile His 
    210                 215                 220                 


Thr Gly Glu Lys Pro His Lys Cys Gln Val Cys Gly Lys Ala Phe Ser 
225                 230                 235                 240 


Gln Ser Ser Asn Leu Ile Thr His Ser Arg Lys His Thr Gly Phe Lys 
                245                 250                 255     


Pro Phe Ser Cys Glu Leu Cys Thr Lys Gly Phe Gln Arg Lys Val Asp 
            260                 265                 270         


Leu Arg Arg His Arg Glu Ser Gln His Asn Leu Lys 
        275                 280                 


<210>  4419
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFI1__Homo_sapiens__XP_011539548

<400>  4419

Met Pro Arg Ser Phe Leu Val Lys Ser Lys Lys Ala His Ser Tyr His 
1               5                   10                  15      


Gln Pro Arg Ser Pro Gly Pro Asp Tyr Ser Leu Arg Leu Glu Asn Val 
            20                  25                  30          


Pro Ala Pro Ser Arg Ala Asp Ser Thr Ser Asn Ala Gly Gly Ala Lys 
        35                  40                  45              


Ala Glu Pro Arg Asp Arg Leu Ser Pro Glu Ser Gln Leu Thr Glu Ala 
    50                  55                  60                  


Pro Asp Arg Ala Ser Ala Ser Pro Asp Ser Cys Glu Gly Ser Val Cys 
65                  70                  75                  80  


Glu Arg Ser Ser Glu Phe Glu Asp Phe Trp Arg Pro Pro Ser Pro Ser 
                85                  90                  95      


Ala Ser Pro Ala Ser Glu Lys Ser Met Cys Pro Ser Leu Asp Glu Ala 
            100                 105                 110         


Gln Pro Phe Pro Leu Pro Phe Lys Pro Tyr Ser Trp Ser Gly Leu Ala 
        115                 120                 125             


Gly Ser Asp Leu Arg His Leu Val Gln Ser Tyr Arg Pro Cys Gly Ala 
    130                 135                 140                 


Leu Glu Arg Gly Ala Gly Leu Gly Leu Phe Cys Glu Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Gly His Pro Ala Ala Leu Tyr Gly Pro Lys Arg Ala Ala Gly Gly 
                165                 170                 175     


Ala Gly Ala Gly Ala Pro Gly Ser Cys Ser Ala Gly Ala Gly Ala Thr 
            180                 185                 190         


Ala Gly Pro Gly Leu Gly Leu Tyr Gly Asp Phe Gly Ser Ala Ala Ala 
        195                 200                 205             


Gly Leu Tyr Glu Arg Pro Thr Ala Ala Ala Gly Leu Leu Tyr Pro Glu 
    210                 215                 220                 


Arg Gly His Gly Leu His Ala Asp Lys Gly Ala Gly Val Lys Val Glu 
225                 230                 235                 240 


Ser Glu Leu Leu Cys Thr Arg Leu Leu Leu Gly Gly Gly Ser Tyr Lys 
                245                 250                 255     


Cys Ile Lys Cys Ser Lys Val Phe Ser Thr Pro His Gly Leu Glu Val 
            260                 265                 270         


His Val Arg Arg Ser His Ser Gly Thr Arg Pro Phe Ala Cys Glu Met 
        275                 280                 285             


Cys Gly Lys Thr Phe Gly His Ala Val Ser Leu Glu Gln His Lys Ala 
    290                 295                 300                 


Val His Ser Gln Glu Arg Ser Phe Asp Cys Lys Ile Cys Gly Lys Ser 
305                 310                 315                 320 


Phe Lys Arg Ser Ser Thr Leu Ser Thr His Leu Leu Ile His Ser Asp 
                325                 330                 335     


Thr Arg Pro Tyr Pro Cys Gln Tyr Cys Gly Lys Arg Phe His Gln Lys 
            340                 345                 350         


Ser Asp Met Lys Lys His Thr Phe Ile His Thr Gly Glu Lys Pro His 
        355                 360                 365             


Lys Cys Gln Val Cys Gly Lys Ala Phe Ser Gln Ser Ser Asn Leu Ile 
    370                 375                 380                 


Thr His Ser Arg Lys His Thr Gly Phe Lys Pro Phe Gly Cys Asp Leu 
385                 390                 395                 400 


Cys Gly Lys Gly Phe Gln Arg Lys Val Asp Leu Arg Arg His Arg Glu 
                405                 410                 415     


Thr Gln His Gly Leu Lys 
            420         


<210>  4420
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFM1__Homo_sapiens__NP_079272

<400>  4420

Met Arg Leu Leu Gly Ala Ala Ala Val Ala Ala Leu Gly Arg Gly Arg 
1               5                   10                  15      


Ala Pro Ala Ser Leu Gly Trp Gln Arg Lys Gln Val Asn Trp Lys Ala 
            20                  25                  30          


Cys Arg Trp Ser Ser Ser Gly Val Ile Pro Asn Glu Lys Ile Arg Asn 
        35                  40                  45              


Ile Gly Ile Ser Ala His Ile Asp Ser Gly Lys Thr Thr Leu Thr Glu 
    50                  55                  60                  


Arg Val Leu Tyr Tyr Thr Gly Arg Ile Ala Lys Met His Glu Val Lys 
65                  70                  75                  80  


Gly Lys Asp Gly Val Gly Ala Val Met Asp Ser Met Glu Leu Glu Arg 
                85                  90                  95      


Gln Arg Gly Ile Thr Ile Gln Ser Ala Ala Thr Tyr Thr Met Trp Lys 
            100                 105                 110         


Asp Val Asn Ile Asn Ile Ile Asp Thr Pro Gly His Val Asp Phe Thr 
        115                 120                 125             


Ile Glu Val Glu Arg Ala Leu Arg Val Leu Asp Gly Ala Val Leu Val 
    130                 135                 140                 


Leu Cys Ala Val Gly Gly Val Gln Cys Gln Thr Met Thr Val Asn Arg 
145                 150                 155                 160 


Gln Met Lys Arg Tyr Asn Val Pro Phe Leu Thr Phe Ile Asn Lys Leu 
                165                 170                 175     


Asp Arg Met Gly Ser Asn Pro Ala Arg Ala Leu Gln Gln Met Arg Ser 
            180                 185                 190         


Lys Leu Asn His Asn Ala Ala Phe Met Gln Ile Pro Met Gly Leu Glu 
        195                 200                 205             


Gly Asn Phe Lys Gly Ile Val Asp Leu Ile Glu Glu Arg Ala Ile Tyr 
    210                 215                 220                 


Phe Asp Gly Asp Phe Gly Gln Ile Val Arg Tyr Gly Glu Ile Pro Ala 
225                 230                 235                 240 


Glu Leu Arg Ala Ala Ala Thr Asp His Arg Gln Glu Leu Ile Glu Cys 
                245                 250                 255     


Val Ala Asn Ser Asp Glu Gln Leu Gly Glu Met Phe Leu Glu Glu Lys 
            260                 265                 270         


Ile Pro Ser Ile Ser Asp Leu Lys Leu Ala Ile Arg Arg Ala Thr Leu 
        275                 280                 285             


Lys Arg Ser Phe Thr Pro Val Phe Leu Gly Ser Ala Leu Lys Asn Lys 
    290                 295                 300                 


Gly Val Gln Pro Leu Leu Asp Ala Val Leu Glu Tyr Leu Pro Asn Pro 
305                 310                 315                 320 


Ser Glu Val Gln Asn Tyr Ala Ile Leu Asn Lys Glu Asp Asp Ser Lys 
                325                 330                 335     


Glu Lys Thr Lys Ile Leu Met Asn Ser Ser Arg Asp Asn Ser His Pro 
            340                 345                 350         


Phe Val Gly Leu Ala Phe Lys Leu Glu Val Gly Arg Phe Gly Gln Leu 
        355                 360                 365             


Thr Tyr Val Arg Ser Tyr Gln Gly Glu Leu Lys Lys Gly Asp Thr Ile 
    370                 375                 380                 


Tyr Asn Thr Arg Thr Arg Lys Lys Val Arg Leu Gln Arg Leu Ala Arg 
385                 390                 395                 400 


Met His Ala Asp Met Met Glu Asp Val Glu Glu Val Tyr Ala Gly Asp 
                405                 410                 415     


Ile Cys Ala Leu Phe Gly Ile Asp Cys Ala Ser Gly Asp Thr Phe Thr 
            420                 425                 430         


Asp Lys Ala Asn Ser Gly Leu Ser Met Glu Ser Ile His Val Pro Asp 
        435                 440                 445             


Pro Val Ile Ser Ile Ala Met Lys Pro Ser Asn Lys Asn Asp Leu Glu 
    450                 455                 460                 


Lys Phe Ser Lys Gly Ile Gly Arg Phe Thr Arg Glu Asp Pro Thr Phe 
465                 470                 475                 480 


Lys Val Tyr Phe Asp Thr Glu Asn Lys Glu Thr Val Ile Ser Gly Met 
                485                 490                 495     


Gly Glu Leu His Leu Glu Ile Tyr Ala Gln Arg Leu Glu Arg Glu Tyr 
            500                 505                 510         


Gly Cys Pro Cys Ile Thr Gly Lys Pro Lys Val Ala Phe Arg Glu Thr 
        515                 520                 525             


Ile Thr Ala Pro Val Pro Phe Asp Phe Thr His Lys Lys Gln Ser Gly 
    530                 535                 540                 


Gly Ala Gly Gln Tyr Gly Lys Val Ile Gly Val Leu Glu Pro Leu Asp 
545                 550                 555                 560 


Pro Glu Asp Tyr Thr Lys Leu Glu Phe Ser Asp Glu Thr Phe Gly Ser 
                565                 570                 575     


Asn Ile Pro Lys Gln Phe Val Pro Ala Val Glu Lys Gly Phe Leu Asp 
            580                 585                 590         


Ala Cys Glu Lys Gly Pro Leu Ser Gly His Lys Leu Ser Gly Leu Arg 
        595                 600                 605             


Phe Val Leu Gln Asp Gly Ala His His Met Val Asp Ser Asn Glu Ile 
    610                 615                 620                 


Ser Phe Ile Arg Ala Gly Glu Gly Ala Leu Lys Gln Ala Leu Ala Asn 
625                 630                 635                 640 


Ala Thr Leu Cys Ile Leu Glu Pro Ile Met Ala Val Glu Val Val Ala 
                645                 650                 655     


Pro Asn Glu Phe Gln Gly Gln Val Ile Ala Gly Ile Asn Arg Arg His 
            660                 665                 670         


Gly Val Ile Thr Gly Gln Asp Gly Val Glu Asp Tyr Phe Thr Leu Tyr 
        675                 680                 685             


Ala Asp Val Pro Leu Asn Asp Met Phe Gly Tyr Ser Thr Glu Leu Arg 
    690                 695                 700                 


Ser Cys Thr Glu Gly Lys Gly Glu Tyr Thr Met Glu Tyr Ser Arg Tyr 
705                 710                 715                 720 


Gln Pro Cys Leu Pro Ser Thr Gln Glu Asp Val Ile Asn Lys Tyr Leu 
                725                 730                 735     


Glu Ala Thr Gly Gln Leu Pro Val Lys Lys Gly Lys Ala Lys Asn 
            740                 745                 750     


<210>  4421
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFPT1__Homo_sapiens__NP_001231639

<400>  4421

Met Cys Gly Ile Phe Ala Tyr Leu Asn Tyr His Val Pro Arg Thr Arg 
1               5                   10                  15      


Arg Glu Ile Leu Glu Thr Leu Ile Lys Gly Leu Gln Arg Leu Glu Tyr 
            20                  25                  30          


Arg Gly Tyr Asp Ser Ala Gly Val Gly Phe Asp Gly Gly Asn Asp Lys 
        35                  40                  45              


Asp Trp Glu Ala Asn Ala Cys Lys Ile Gln Leu Ile Lys Lys Lys Gly 
    50                  55                  60                  


Lys Val Lys Ala Leu Asp Glu Glu Val His Lys Gln Gln Asp Met Asp 
65                  70                  75                  80  


Leu Asp Ile Glu Phe Asp Val His Leu Gly Ile Ala His Thr Arg Trp 
                85                  90                  95      


Ala Thr His Gly Glu Pro Ser Pro Val Asn Ser His Pro Gln Arg Ser 
            100                 105                 110         


Asp Lys Asn Asn Glu Phe Ile Val Ile His Asn Gly Ile Ile Thr Asn 
        115                 120                 125             


Tyr Lys Asp Leu Lys Lys Phe Leu Glu Ser Lys Gly Tyr Asp Phe Glu 
    130                 135                 140                 


Ser Glu Thr Asp Thr Glu Thr Ile Ala Lys Leu Val Lys Tyr Met Tyr 
145                 150                 155                 160 


Asp Asn Arg Glu Ser Gln Asp Thr Ser Phe Thr Thr Leu Val Glu Arg 
                165                 170                 175     


Val Ile Gln Gln Leu Glu Gly Ala Phe Ala Leu Val Phe Lys Ser Val 
            180                 185                 190         


His Phe Pro Gly Gln Ala Val Gly Thr Arg Arg Gly Ser Pro Leu Leu 
        195                 200                 205             


Ile Gly Val Arg Ser Glu His Lys Leu Ser Thr Asp His Ile Pro Ile 
    210                 215                 220                 


Leu Tyr Arg Thr Ala Arg Thr Gln Ile Gly Ser Lys Phe Thr Arg Trp 
225                 230                 235                 240 


Gly Ser Gln Gly Glu Arg Gly Lys Asp Lys Lys Gly Ser Cys Asn Leu 
                245                 250                 255     


Ser Arg Val Asp Ser Thr Thr Cys Leu Phe Pro Val Glu Glu Lys Ala 
            260                 265                 270         


Val Glu Tyr Tyr Phe Ala Ser Asp Ala Ser Ala Val Ile Glu His Thr 
        275                 280                 285             


Asn Arg Val Ile Phe Leu Glu Asp Asp Asp Val Ala Ala Val Val Asp 
    290                 295                 300                 


Gly Arg Leu Ser Ile His Arg Ile Lys Arg Thr Ala Gly Asp His Pro 
305                 310                 315                 320 


Gly Arg Ala Val Gln Thr Leu Gln Met Glu Leu Gln Gln Ile Met Lys 
                325                 330                 335     


Gly Asn Phe Ser Ser Phe Met Gln Lys Glu Ile Phe Glu Gln Pro Glu 
            340                 345                 350         


Ser Val Val Asn Thr Met Arg Gly Arg Val Asn Phe Asp Asp Tyr Thr 
        355                 360                 365             


Val Asn Leu Gly Gly Leu Lys Asp His Ile Lys Glu Ile Gln Arg Cys 
    370                 375                 380                 


Arg Arg Leu Ile Leu Ile Ala Cys Gly Thr Ser Tyr His Ala Gly Val 
385                 390                 395                 400 


Ala Thr Arg Gln Val Leu Glu Glu Leu Thr Glu Leu Pro Val Met Val 
                405                 410                 415     


Glu Leu Ala Ser Asp Phe Leu Asp Arg Asn Thr Pro Val Phe Arg Asp 
            420                 425                 430         


Asp Val Cys Phe Phe Leu Ser Gln Ser Gly Glu Thr Ala Asp Thr Leu 
        435                 440                 445             


Met Gly Leu Arg Tyr Cys Lys Glu Arg Gly Ala Leu Thr Val Gly Ile 
    450                 455                 460                 


Thr Asn Thr Val Gly Ser Ser Ile Ser Arg Glu Thr Asp Cys Gly Val 
465                 470                 475                 480 


His Ile Asn Ala Gly Pro Glu Ile Gly Val Ala Ser Thr Lys Ala Tyr 
                485                 490                 495     


Thr Ser Gln Phe Val Ser Leu Val Met Phe Ala Leu Met Met Cys Asp 
            500                 505                 510         


Asp Arg Ile Ser Met Gln Glu Arg Arg Lys Glu Ile Met Leu Gly Leu 
        515                 520                 525             


Lys Arg Leu Pro Asp Leu Ile Lys Glu Val Leu Ser Met Asp Asp Glu 
    530                 535                 540                 


Ile Gln Lys Leu Ala Thr Glu Leu Tyr His Gln Lys Ser Val Leu Ile 
545                 550                 555                 560 


Met Gly Arg Gly Tyr His Tyr Ala Thr Cys Leu Glu Gly Ala Leu Lys 
                565                 570                 575     


Ile Lys Glu Ile Thr Tyr Met His Ser Glu Gly Ile Leu Ala Gly Glu 
            580                 585                 590         


Leu Lys His Gly Pro Leu Ala Leu Val Asp Lys Leu Met Pro Val Ile 
        595                 600                 605             


Met Ile Ile Met Arg Asp His Thr Tyr Ala Lys Cys Gln Asn Ala Leu 
    610                 615                 620                 


Gln Gln Val Val Ala Arg Gln Gly Arg Pro Val Val Ile Cys Asp Lys 
625                 630                 635                 640 


Glu Asp Thr Glu Thr Ile Lys Asn Thr Lys Arg Thr Ile Lys Val Pro 
                645                 650                 655     


His Ser Val Asp Cys Leu Gln Gly Ile Leu Ser Val Ile Pro Leu Gln 
            660                 665                 670         


Leu Leu Ala Phe His Leu Ala Val Leu Arg Gly Tyr Asp Val Asp Phe 
        675                 680                 685             


Pro Arg Asn Leu Ala Lys Ser Val Thr Val Glu 
    690                 695                 


<210>  4422
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFPT2__Homo_sapiens__NP_005101

<400>  4422

Met Cys Gly Ile Phe Ala Tyr Met Asn Tyr Arg Val Pro Arg Thr Arg 
1               5                   10                  15      


Lys Glu Ile Phe Glu Thr Leu Ile Lys Gly Leu Gln Arg Leu Glu Tyr 
            20                  25                  30          


Arg Gly Tyr Asp Ser Ala Gly Val Ala Ile Asp Gly Asn Asn His Glu 
        35                  40                  45              


Val Lys Glu Arg His Ile Gln Leu Val Lys Lys Arg Gly Lys Val Lys 
    50                  55                  60                  


Ala Leu Asp Glu Glu Leu Tyr Lys Gln Asp Ser Met Asp Leu Lys Val 
65                  70                  75                  80  


Glu Phe Glu Thr His Phe Gly Ile Ala His Thr Arg Trp Ala Thr His 
                85                  90                  95      


Gly Val Pro Ser Ala Val Asn Ser His Pro Gln Arg Ser Asp Lys Gly 
            100                 105                 110         


Asn Glu Phe Val Val Ile His Asn Gly Ile Ile Thr Asn Tyr Lys Asp 
        115                 120                 125             


Leu Arg Lys Phe Leu Glu Ser Lys Gly Tyr Glu Phe Glu Ser Glu Thr 
    130                 135                 140                 


Asp Thr Glu Thr Ile Ala Lys Leu Ile Lys Tyr Val Phe Asp Asn Arg 
145                 150                 155                 160 


Glu Thr Glu Asp Ile Thr Phe Ser Thr Leu Val Glu Arg Val Ile Gln 
                165                 170                 175     


Gln Leu Glu Gly Ala Phe Ala Leu Val Phe Lys Ser Val His Tyr Pro 
            180                 185                 190         


Gly Glu Ala Val Ala Thr Arg Arg Gly Ser Pro Leu Leu Ile Gly Val 
        195                 200                 205             


Arg Ser Lys Tyr Lys Leu Ser Thr Glu Gln Ile Pro Ile Leu Tyr Arg 
    210                 215                 220                 


Thr Cys Thr Leu Glu Asn Val Lys Asn Ile Cys Lys Thr Arg Met Lys 
225                 230                 235                 240 


Arg Leu Asp Ser Ser Ala Cys Leu His Ala Val Gly Asp Lys Ala Val 
                245                 250                 255     


Glu Phe Phe Phe Ala Ser Asp Ala Ser Ala Ile Ile Glu His Thr Asn 
            260                 265                 270         


Arg Val Ile Phe Leu Glu Asp Asp Asp Ile Ala Ala Val Ala Asp Gly 
        275                 280                 285             


Lys Leu Ser Ile His Arg Val Lys Arg Ser Ala Ser Asp Asp Pro Ser 
    290                 295                 300                 


Arg Ala Ile Gln Thr Leu Gln Met Glu Leu Gln Gln Ile Met Lys Gly 
305                 310                 315                 320 


Asn Phe Ser Ala Phe Met Gln Lys Glu Ile Phe Glu Gln Pro Glu Ser 
                325                 330                 335     


Val Phe Asn Thr Met Arg Gly Arg Val Asn Phe Glu Thr Asn Thr Val 
            340                 345                 350         


Leu Leu Gly Gly Leu Lys Asp His Leu Lys Glu Ile Arg Arg Cys Arg 
        355                 360                 365             


Arg Leu Ile Val Ile Gly Cys Gly Thr Ser Tyr His Ala Ala Val Ala 
    370                 375                 380                 


Thr Arg Gln Val Leu Glu Glu Leu Thr Glu Leu Pro Val Met Val Glu 
385                 390                 395                 400 


Leu Ala Ser Asp Phe Leu Asp Arg Asn Thr Pro Val Phe Arg Asp Asp 
                405                 410                 415     


Val Cys Phe Phe Ile Ser Gln Ser Gly Glu Thr Ala Asp Thr Leu Leu 
            420                 425                 430         


Ala Leu Arg Tyr Cys Lys Asp Arg Gly Ala Leu Thr Val Gly Val Thr 
        435                 440                 445             


Asn Thr Val Gly Ser Ser Ile Ser Arg Glu Thr Asp Cys Gly Val His 
    450                 455                 460                 


Ile Asn Ala Gly Pro Glu Ile Gly Val Ala Ser Thr Lys Ala Tyr Thr 
465                 470                 475                 480 


Ser Gln Phe Ile Ser Leu Val Met Phe Gly Leu Met Met Ser Glu Asp 
                485                 490                 495     


Arg Ile Ser Leu Gln Asn Arg Arg Gln Glu Ile Ile Arg Gly Leu Arg 
            500                 505                 510         


Ser Leu Pro Glu Leu Ile Lys Glu Val Leu Ser Leu Glu Glu Lys Ile 
        515                 520                 525             


His Asp Leu Ala Leu Glu Leu Tyr Thr Gln Arg Ser Leu Leu Val Met 
    530                 535                 540                 


Gly Arg Gly Tyr Asn Tyr Ala Thr Cys Leu Glu Gly Ala Leu Lys Ile 
545                 550                 555                 560 


Lys Glu Ile Thr Tyr Met His Ser Glu Gly Ile Leu Ala Gly Glu Leu 
                565                 570                 575     


Lys His Gly Pro Leu Ala Leu Ile Asp Lys Gln Met Pro Val Ile Met 
            580                 585                 590         


Val Ile Met Lys Asp Pro Cys Phe Ala Lys Cys Gln Asn Ala Leu Gln 
        595                 600                 605             


Gln Val Thr Ala Arg Gln Gly Arg Pro Ile Ile Leu Cys Ser Lys Asp 
    610                 615                 620                 


Asp Thr Glu Ser Ser Lys Phe Ala Tyr Lys Thr Ile Glu Leu Pro His 
625                 630                 635                 640 


Thr Val Asp Cys Leu Gln Gly Ile Leu Ser Val Ile Pro Leu Gln Leu 
                645                 650                 655     


Leu Ser Phe His Leu Ala Val Leu Arg Gly Tyr Asp Val Asp Phe Pro 
            660                 665                 670         


Arg Asn Leu Ala Lys Ser Val Thr Val Glu 
        675                 680         


<210>  4423
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFRA1__Homo_sapiens__NP_001138925

<400>  4423

Met Phe Leu Ala Thr Leu Tyr Phe Ala Leu Pro Leu Leu Asp Leu Leu 
1               5                   10                  15      


Leu Ser Ala Glu Val Ser Gly Gly Asp Arg Leu Asp Cys Val Lys Ala 
            20                  25                  30          


Ser Asp Gln Cys Leu Lys Glu Gln Ser Cys Ser Thr Lys Tyr Arg Thr 
        35                  40                  45              


Leu Arg Gln Cys Val Ala Gly Lys Glu Thr Asn Phe Ser Leu Ala Ser 
    50                  55                  60                  


Gly Leu Glu Ala Lys Asp Glu Cys Arg Ser Ala Met Glu Ala Leu Lys 
65                  70                  75                  80  


Gln Lys Ser Leu Tyr Asn Cys Arg Cys Lys Arg Gly Met Lys Lys Glu 
                85                  90                  95      


Lys Asn Cys Leu Arg Ile Tyr Trp Ser Met Tyr Gln Ser Leu Gln Gly 
            100                 105                 110         


Asn Asp Leu Leu Glu Asp Ser Pro Tyr Glu Pro Val Asn Ser Arg Leu 
        115                 120                 125             


Ser Asp Ile Phe Arg Val Val Pro Phe Ile Ser Val Glu His Ile Pro 
    130                 135                 140                 


Lys Gly Asn Asn Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asp Asp 
145                 150                 155                 160 


Ile Cys Lys Lys Tyr Arg Ser Ala Tyr Ile Thr Pro Cys Thr Thr Ser 
                165                 170                 175     


Val Ser Asn Asp Val Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg 
            180                 185                 190         


Gln Phe Phe Asp Lys Val Pro Ala Lys His Ser Tyr Gly Met Leu Phe 
        195                 200                 205             


Cys Ser Cys Arg Asp Ile Ala Cys Thr Glu Arg Arg Arg Gln Thr Ile 
    210                 215                 220                 


Val Pro Val Cys Ser Tyr Glu Glu Arg Glu Lys Pro Asn Cys Leu Asn 
225                 230                 235                 240 


Leu Gln Asp Ser Cys Lys Thr Asn Tyr Ile Cys Arg Ser Arg Leu Ala 
                245                 250                 255     


Asp Phe Phe Thr Asn Cys Gln Pro Glu Ser Arg Ser Val Ser Ser Cys 
            260                 265                 270         


Leu Lys Glu Asn Tyr Ala Asp Cys Leu Leu Ala Tyr Ser Gly Leu Ile 
        275                 280                 285             


Gly Thr Val Met Thr Pro Asn Tyr Ile Asp Ser Ser Ser Leu Ser Val 
    290                 295                 300                 


Ala Pro Trp Cys Asp Cys Ser Asn Ser Gly Asn Asp Leu Glu Glu Cys 
305                 310                 315                 320 


Leu Lys Phe Leu Asn Phe Phe Lys Asp Asn Thr Cys Leu Lys Asn Ala 
                325                 330                 335     


Ile Gln Ala Phe Gly Asn Gly Ser Asp Val Thr Val Trp Gln Pro Ala 
            340                 345                 350         


Phe Pro Val Gln Thr Thr Thr Ala Thr Thr Thr Thr Ala Leu Arg Val 
        355                 360                 365             


Lys Asn Lys Pro Leu Gly Pro Ala Gly Ser Glu Asn Glu Ile Pro Thr 
    370                 375                 380                 


His Val Leu Pro Pro Cys Ala Asn Leu Gln Ala Gln Lys Leu Lys Ser 
385                 390                 395                 400 


Asn Val Ser Gly Asn Thr His Leu Cys Ile Ser Asn Gly Asn Tyr Glu 
                405                 410                 415     


Lys Glu Gly Leu Gly Ala Ser Ser His Ile Thr Thr Lys Ser Met Ala 
            420                 425                 430         


Ala Pro Pro Ser Cys Gly Leu Ser Pro Leu Leu Val Leu Val Val Thr 
        435                 440                 445             


Ala Leu Ser Thr Leu Leu Ser Leu Thr Glu Thr Ser 
    450                 455                 460 


<210>  4424
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFRA2__Homo_sapiens__NP_001158511

<400>  4424

Met Ile Leu Ala Asn Val Phe Cys Leu Phe Phe Phe Leu Gly Thr Gly 
1               5                   10                  15      


Ala Asp Pro Val Val Ser Ala Lys Ser Asn His Cys Leu Asp Ala Ala 
            20                  25                  30          


Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys Leu Arg Ser Ser Tyr 
        35                  40                  45              


Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr Glu Arg Cys Asn Arg 
    50                  55                  60                  


Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe Asp Arg Val Pro Ser 
65                  70                  75                  80  


Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys Gln Asp Gln Ala Cys 
                85                  90                  95      


Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser Cys Ser Tyr Glu Asp 
            100                 105                 110         


Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly Val Cys Arg Thr Asp 
        115                 120                 125             


His Leu Cys Arg Ser Arg Leu Ala Asp Phe His Ala Asn Cys Arg Ala 
    130                 135                 140                 


Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp Asn Tyr Gln Ala Cys 
145                 150                 155                 160 


Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp Met Thr Pro Asn Tyr 
                165                 170                 175     


Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser Pro Trp Cys Ser Cys 
            180                 185                 190         


Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu Lys Phe Leu Arg Asp 
        195                 200                 205             


Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile Gln Ala Phe Gly Asn 
    210                 215                 220                 


Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro Ser Phe Gln Ala Thr 
225                 230                 235                 240 


Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu Pro Asp Asp Leu Ser 
                245                 250                 255     


Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr Thr Cys Thr Ser Val 
            260                 265                 270         


Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys Glu Leu Ser Met Cys 
        275                 280                 285             


Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly Ser Asn Lys Val Ile 
    290                 295                 300                 


Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro Ser Ala Ala Leu Thr 
305                 310                 315                 320 


Val Leu Ser Val Leu Met Leu Lys Leu Ala Leu 
                325                 330     


<210>  4425
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFRA3__Homo_sapiens__NP_001487

<400>  4425

Met Val Arg Pro Leu Asn Pro Arg Pro Leu Pro Pro Val Val Leu Met 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Pro Ser Pro Leu Pro Leu Ala Ala Gly Asp 
            20                  25                  30          


Pro Leu Pro Thr Glu Ser Arg Leu Met Asn Ser Cys Leu Gln Ala Arg 
        35                  40                  45              


Arg Lys Cys Gln Ala Asp Pro Thr Cys Ser Ala Ala Tyr His His Leu 
    50                  55                  60                  


Asp Ser Cys Thr Ser Ser Ile Ser Thr Pro Leu Pro Ser Glu Glu Pro 
65                  70                  75                  80  


Ser Val Pro Ala Asp Cys Leu Glu Ala Ala Gln Gln Leu Arg Asn Ser 
                85                  90                  95      


Ser Leu Ile Gly Cys Met Cys His Arg Arg Met Lys Asn Gln Val Ala 
            100                 105                 110         


Cys Leu Asp Ile Tyr Trp Thr Val His Arg Ala Arg Ser Leu Gly Asn 
        115                 120                 125             


Tyr Glu Leu Asp Val Ser Pro Tyr Glu Asp Thr Val Thr Ser Lys Pro 
    130                 135                 140                 


Trp Lys Met Asn Leu Ser Lys Leu Asn Met Leu Lys Pro Asp Ser Asp 
145                 150                 155                 160 


Leu Cys Leu Lys Phe Ala Met Leu Cys Thr Leu Asn Asp Lys Cys Asp 
                165                 170                 175     


Arg Leu Arg Lys Ala Tyr Gly Glu Ala Cys Ser Gly Pro His Cys Gln 
            180                 185                 190         


Arg His Val Cys Leu Arg Gln Leu Leu Thr Phe Phe Glu Lys Ala Ala 
        195                 200                 205             


Glu Pro His Ala Gln Gly Leu Leu Leu Cys Pro Cys Ala Pro Asn Asp 
    210                 215                 220                 


Arg Gly Cys Gly Glu Arg Arg Arg Asn Thr Ile Ala Pro Asn Cys Ala 
225                 230                 235                 240 


Leu Pro Pro Val Ala Pro Asn Cys Leu Glu Leu Arg Arg Leu Cys Phe 
                245                 250                 255     


Ser Asp Pro Leu Cys Arg Ser Arg Leu Val Asp Phe Gln Thr His Cys 
            260                 265                 270         


His Pro Met Asp Ile Leu Gly Thr Cys Ala Thr Glu Gln Ser Arg Cys 
        275                 280                 285             


Leu Arg Ala Tyr Leu Gly Leu Ile Gly Thr Ala Met Thr Pro Asn Phe 
    290                 295                 300                 


Val Ser Asn Val Asn Thr Ser Val Ala Leu Ser Cys Thr Cys Arg Gly 
305                 310                 315                 320 


Ser Gly Asn Leu Gln Glu Glu Cys Glu Met Leu Glu Gly Phe Phe Ser 
                325                 330                 335     


His Asn Pro Cys Leu Thr Glu Ala Ile Ala Ala Lys Met Arg Phe His 
            340                 345                 350         


Ser Gln Leu Phe Ser Gln Asp Trp Pro His Pro Thr Phe Ala Val Met 
        355                 360                 365             


Ala His Gln Asn Glu Asn Pro Ala Val Arg Pro Gln Pro Trp Val Pro 
    370                 375                 380                 


Ser Leu Phe Ser Cys Thr Leu Pro Leu Ile Leu Leu Leu Ser Leu Trp 
385                 390                 395                 400 


<210>  4426
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFRA4__Homo_sapiens__NP_071422

<400>  4426

Met Val Arg Cys Leu Gly Pro Ala Leu Leu Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ser Ala Ser Ser Val Gly Gly Asn Arg Cys Val Asp Ala Ala Glu Ala 
            20                  25                  30          


Cys Thr Ala Asp Ala Arg Cys Gln Arg Leu Arg Ser Glu Tyr Val Ala 
        35                  40                  45              


Gln Cys Leu Gly Arg Ala Ala Gln Gly Gly Cys Pro Arg Ala Arg Cys 
    50                  55                  60                  


Arg Arg Ala Leu Arg Arg Phe Phe Ala Arg Gly Pro Pro Ala Leu Thr 
65                  70                  75                  80  


His Ala Leu Leu Phe Cys Pro Cys Ala Gly Pro Ala Cys Ala Glu Arg 
                85                  90                  95      


Arg Arg Gln Thr Phe Val Pro Ser Cys Ala Phe Ser Gly Pro Gly Pro 
            100                 105                 110         


Ala Pro Pro Ser Cys Leu Glu Pro Leu Asn Phe Cys Glu Arg Ser Arg 
        115                 120                 125             


Val Cys Arg Pro Arg Leu Leu Ala Phe Gln Val Ser Cys Thr Pro Ala 
    130                 135                 140                 


Pro Ser Ala Pro Asp Gly Cys Leu Leu Asp Gln Gly Ala Arg Cys Leu 
145                 150                 155                 160 


Arg Ala Tyr Ala Gly Leu Val Gly Thr Ala Val Thr Pro Asn Tyr Val 
                165                 170                 175     


Asp Asn Val Ser Ala Arg Val Ala Pro Trp Cys Asp Cys Gly Ala Ser 
            180                 185                 190         


Gly Asn Arg Arg Glu Asp Cys Glu Ala Phe Arg Gly Leu Phe Thr Arg 
        195                 200                 205             


Asn Arg Cys Leu Asp Gly Ala Ile Gln Ala Phe Ala Ser Gly Trp Pro 
    210                 215                 220                 


Pro Val Leu Leu Asp Gln Leu Asn Pro Gln Gly Asp Pro Glu His Ser 
225                 230                 235                 240 


Leu Leu Gln Val Ser Ser Thr Gly Arg Ala Leu Glu Arg Arg Ser Leu 
                245                 250                 255     


Leu Ser Ile Leu Pro Val Leu Ala Leu Pro Ala Leu Leu 
            260                 265                 


<210>  4427
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGA1__Homo_sapiens__NP_001001560

<400>  4427

Met Glu Pro Ala Met Glu Pro Glu Thr Leu Glu Ala Arg Ile Asn Arg 
1               5                   10                  15      


Ala Thr Asn Pro Leu Asn Lys Glu Leu Asp Trp Ala Ser Ile Asn Gly 
            20                  25                  30          


Phe Cys Glu Gln Leu Asn Glu Asp Phe Glu Gly Pro Pro Leu Ala Thr 
        35                  40                  45              


Arg Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Trp Glu Ala Ile 
    50                  55                  60                  


Gln Ala Leu Thr Val Leu Glu Thr Cys Met Lys Ser Cys Gly Lys Arg 
65                  70                  75                  80  


Phe His Asp Glu Val Gly Lys Phe Arg Phe Leu Asn Glu Leu Ile Lys 
                85                  90                  95      


Val Val Ser Pro Lys Tyr Leu Gly Ser Arg Thr Ser Glu Lys Val Lys 
            100                 105                 110         


Asn Lys Ile Leu Glu Leu Leu Tyr Ser Trp Thr Val Gly Leu Pro Glu 
        115                 120                 125             


Glu Val Lys Ile Ala Glu Ala Tyr Gln Met Leu Lys Lys Gln Gly Ile 
    130                 135                 140                 


Val Lys Ser Asp Pro Lys Leu Pro Asp Asp Thr Thr Phe Pro Leu Pro 
145                 150                 155                 160 


Pro Pro Arg Pro Lys Asn Val Ile Phe Glu Asp Glu Glu Lys Ser Lys 
                165                 170                 175     


Met Leu Ala Arg Leu Leu Lys Ser Ser His Pro Glu Asp Leu Arg Ala 
            180                 185                 190         


Ala Asn Lys Leu Ile Lys Glu Met Val Gln Glu Asp Gln Lys Arg Met 
        195                 200                 205             


Glu Lys Ile Ser Lys Arg Val Asn Ala Ile Glu Glu Val Asn Asn Asn 
    210                 215                 220                 


Val Lys Leu Leu Thr Glu Met Val Met Ser His Ser Gln Gly Gly Ala 
225                 230                 235                 240 


Ala Ala Gly Ser Ser Glu Asp Leu Met Lys Glu Leu Tyr Gln Arg Cys 
                245                 250                 255     


Glu Arg Met Arg Pro Thr Leu Phe Arg Leu Ala Ser Asp Thr Glu Asp 
            260                 265                 270         


Asn Asp Glu Ala Leu Gly Leu Ser Asp Pro Thr Pro Pro Ser Gly Pro 
        275                 280                 285             


Ser Leu Asp Gly Thr Gly Trp Asn Ser Phe Gln Ser Ser Asp Ala Thr 
    290                 295                 300                 


Glu Pro Pro Ala Pro Ala Leu Ala Gln Ala Pro Ser Met Glu Ser Arg 
305                 310                 315                 320 


Pro Pro Ala Gln Thr Ser Leu Pro Ala Ser Ser Gly Leu Asp Asp Leu 
                325                 330                 335     


Asp Leu Leu Gly Lys Thr Leu Leu Gln Gln Ser Leu Pro Pro Glu Ser 
            340                 345                 350         


Gln Gln Val Arg Trp Glu Lys Gln Gln Pro Thr Pro Arg Leu Thr Leu 
        355                 360                 365             


Arg Asp Leu Gln Asn Lys Ser Ser Ser Cys Ser Ser Pro Ser Ser Ser 
    370                 375                 380                 


Ala Thr Ser Leu Leu His Thr Val Ser Pro Glu Pro Pro Arg Pro Pro 
385                 390                 395                 400 


Gln Gln Pro Val Pro Thr Glu Leu Ser Leu Ala Ser Ile Thr Val Pro 
                405                 410                 415     


Leu Glu Ser Ile Lys Pro Ser Asn Ile Leu Pro Val Thr Val Tyr Asp 
            420                 425                 430         


Gln His Gly Phe Arg Ile Leu Phe His Phe Ala Arg Asp Pro Leu Pro 
        435                 440                 445             


Gly Arg Ser Asp Val Leu Val Val Val Val Ser Met Leu Ser Thr Ala 
    450                 455                 460                 


Pro Gln Pro Ile Arg Asn Ile Val Phe Gln Ser Ala Val Pro Lys Val 
465                 470                 475                 480 


Met Lys Val Lys Leu Gln Pro Pro Ser Gly Thr Glu Leu Pro Ala Phe 
                485                 490                 495     


Asn Pro Ile Val His Pro Ser Ala Ile Thr Gln Val Leu Leu Leu Ala 
            500                 505                 510         


Asn Pro Gln Lys Glu Lys Val Arg Leu Arg Tyr Lys Leu Thr Phe Thr 
        515                 520                 525             


Met Gly Asp Gln Thr Tyr Asn Glu Met Gly Asp Val Asp Gln Phe Pro 
    530                 535                 540                 


Pro Pro Glu Thr Trp Gly Ser Leu 
545                 550         


<210>  4428
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGA3__Homo_sapiens__NP_001166175

<400>  4428

Met Ala Leu Pro Glu Glu Ala Lys Ile Lys Asp Ala Tyr His Met Leu 
1               5                   10                  15      


Lys Arg Gln Gly Ile Val Gln Ser Asp Pro Pro Ile Pro Val Asp Arg 
            20                  25                  30          


Thr Leu Ile Pro Ser Pro Pro Pro Arg Pro Lys Asn Pro Val Phe Asp 
        35                  40                  45              


Asp Glu Glu Lys Ser Lys Leu Leu Ala Lys Leu Leu Lys Ser Lys Asn 
    50                  55                  60                  


Pro Asp Asp Leu Gln Glu Ala Asn Lys Leu Ile Lys Ser Met Val Lys 
65                  70                  75                  80  


Glu Asp Glu Ala Arg Ile Gln Lys Val Thr Lys Arg Leu His Thr Leu 
                85                  90                  95      


Glu Glu Val Asn Asn Asn Val Arg Leu Leu Ser Glu Met Leu Leu His 
            100                 105                 110         


Tyr Ser Gln Glu Asp Ser Ser Asp Gly Asp Arg Glu Leu Met Lys Glu 
        115                 120                 125             


Leu Phe Asp Gln Cys Glu Asn Lys Arg Arg Thr Leu Phe Lys Leu Ala 
    130                 135                 140                 


Ser Glu Thr Glu Asp Asn Asp Asn Ser Leu Gly Asp Ile Leu Gln Ala 
145                 150                 155                 160 


Ser Asp Asn Leu Ser Arg Val Ile Asn Ser Tyr Lys Thr Ile Ile Glu 
                165                 170                 175     


Gly Gln Val Ile Asn Gly Glu Val Ala Thr Leu Thr Leu Pro Asp Ser 
            180                 185                 190         


Glu Gly Asn Ser Gln Cys Ser Asn Gln Gly Thr Leu Ile Asp Leu Ala 
        195                 200                 205             


Glu Leu Asp Thr Thr Asn Ser Leu Ser Ser Val Leu Ala Pro Ala Pro 
    210                 215                 220                 


Thr Pro Pro Ser Ser Gly Ile Pro Ile Leu Pro Pro Pro Pro Gln Ala 
225                 230                 235                 240 


Ser Gly Pro Pro Arg Ser Arg Ser Ser Ser Gln Ala Glu Ala Thr Leu 
                245                 250                 255     


Gly Pro Ser Ser Thr Ser Asn Ala Leu Ser Trp Leu Asp Glu Glu Leu 
            260                 265                 270         


Leu Cys Leu Gly Leu Ala Asp Pro Ala Pro Asn Val Pro Pro Lys Glu 
        275                 280                 285             


Ser Ala Gly Asn Ser Gln Trp His Leu Leu Gln Arg Glu Gln Ser Asp 
    290                 295                 300                 


Leu Asp Phe Phe Ser Pro Arg Pro Gly Thr Ala Ala Cys Gly Ala Ser 
305                 310                 315                 320 


Asp Ala Pro Leu Leu Gln Pro Ser Ala Pro Ser Ser Ser Ser Ser Gln 
                325                 330                 335     


Ala Pro Leu Pro Pro Pro Phe Pro Ala Pro Val Val Pro Ala Ser Val 
            340                 345                 350         


Pro Ala Pro Ser Ala Gly Ser Ser Leu Phe Ser Thr Gly Val Ala Pro 
        355                 360                 365             


Ala Leu Ala Pro Lys Val Glu Pro Ala Val Pro Gly His His Gly Leu 
    370                 375                 380                 


Ala Leu Gly Asn Ser Ala Leu His His Leu Asp Ala Leu Asp Gln Leu 
385                 390                 395                 400 


Leu Glu Glu Ala Lys Val Thr Ser Gly Leu Val Lys Pro Thr Thr Ser 
                405                 410                 415     


Pro Leu Ile Pro Thr Thr Thr Pro Ala Arg Pro Leu Leu Pro Phe Ser 
            420                 425                 430         


Thr Gly Pro Gly Ser Pro Leu Phe Gln Pro Leu Ser Phe Gln Ser Gln 
        435                 440                 445             


Gly Ser Pro Pro Lys Gly Pro Glu Leu Ser Leu Ala Ser Ile His Val 
    450                 455                 460                 


Pro Leu Glu Ser Ile Lys Pro Ser Ser Ala Leu Pro Val Thr Ala Tyr 
465                 470                 475                 480 


Asp Lys Asn Gly Phe Arg Ile Leu Phe His Phe Ala Lys Glu Cys Pro 
                485                 490                 495     


Pro Gly Arg Pro Asp Val Leu Val Val Val Val Ser Met Leu Asn Thr 
            500                 505                 510         


Ala Pro Leu Pro Val Lys Ser Ile Val Leu Gln Ala Ala Val Pro Lys 
        515                 520                 525             


Ser Met Lys Val Lys Leu Gln Pro Pro Ser Gly Thr Glu Leu Ser Pro 
    530                 535                 540                 


Phe Ser Pro Ile Gln Pro Pro Ala Ala Ile Thr Gln Val Met Leu Leu 
545                 550                 555                 560 


Ala Asn Pro Leu Lys Lys Gln Val Leu Ser Phe Leu Gly Lys Ala Cys 
                565                 570                 575     


Leu Gln Pro Trp Gly Gln Ala Ile Leu Leu Thr Thr Ser Cys Leu Ala 
            580                 585                 590         


<210>  4429
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGACT__Homo_sapiens__NP_149101

<400>  4429

Met Ala Leu Val Phe Val Tyr Gly Thr Leu Lys Arg Gly Gln Pro Asn 
1               5                   10                  15      


His Arg Val Leu Arg Asp Gly Ala His Gly Ser Ala Ala Phe Arg Ala 
            20                  25                  30          


Arg Gly Arg Thr Leu Glu Pro Tyr Pro Leu Val Ile Ala Gly Glu His 
        35                  40                  45              


Asn Ile Pro Trp Leu Leu His Leu Pro Gly Ser Gly Arg Leu Val Glu 
    50                  55                  60                  


Gly Glu Val Tyr Ala Val Asp Glu Arg Met Leu Arg Phe Leu Asp Asp 
65                  70                  75                  80  


Phe Glu Ser Cys Pro Ala Leu Tyr Gln Arg Thr Val Leu Arg Val Gln 
                85                  90                  95      


Leu Leu Glu Asp Arg Ala Pro Gly Ala Glu Glu Pro Pro Ala Pro Thr 
            100                 105                 110         


Ala Val Gln Cys Phe Val Tyr Ser Arg Ala Thr Phe Pro Pro Glu Trp 
        115                 120                 125             


Ala Gln Leu Pro His His Asp Ser Tyr Asp Ser Glu Gly Pro His Gly 
    130                 135                 140                 


Leu Arg Tyr Asn Pro Arg Glu Asn Arg 
145                 150             


<210>  4430
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGCT__Homo_sapiens__NP_001186744

<400>  4430

Met Ala Asn Ser Gly Cys Lys Asp Val Thr Gly Pro Asp Glu Glu Ser 
1               5                   10                  15      


Phe Leu Tyr Phe Ala Tyr Gly Ser Asn Leu Leu Thr Glu Arg Ile His 
            20                  25                  30          


Leu Arg Asn Pro Ser Ala Ala Phe Phe Cys Val Ala Arg Leu Gln Asp 
        35                  40                  45              


Phe Lys Leu Asp Phe Gly Asn Ser Gln Gly Lys Thr Ser Gln Thr Trp 
    50                  55                  60                  


His Gly Gly Ile Ala Thr Ile Phe Gln Ser Pro Gly Asp Glu Val Trp 
65                  70                  75                  80  


Gly Val Val Trp Lys Met Asn Lys Ser Asn Leu Asn Ser Leu Asp Glu 
                85                  90                  95      


Trp Arg Lys Lys Arg His Thr Ala Phe Gln Asn Gln Gly Asn His Pro 
            100                 105                 110         


Cys Lys His Lys Thr Arg Met Trp Asp Arg Asp Pro Lys Ile Pro Val 
        115                 120                 125             


Gln Asn Leu Ser Leu Ala Leu Cys Trp Gln Ala Gln Ser Gly His Gly 
    130                 135                 140                 


Thr Cys Asn Arg Leu Phe Ala Trp Val Gln Lys Lys Met Val Cys Arg 
145                 150                 155                 160 


Trp Ser Ile Lys Arg Ser 
                165     


<210>  4431
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGCX__Homo_sapiens__NP_000812

<400>  4431

Met Ala Val Ser Ala Gly Ser Ala Arg Thr Ser Pro Ser Ser Asp Lys 
1               5                   10                  15      


Val Gln Lys Asp Lys Ala Glu Leu Ile Ser Gly Pro Arg Gln Asp Ser 
            20                  25                  30          


Arg Ile Gly Lys Leu Leu Gly Phe Glu Trp Thr Asp Leu Ser Ser Trp 
        35                  40                  45              


Arg Arg Leu Val Thr Leu Leu Asn Arg Pro Thr Asp Pro Ala Ser Leu 
    50                  55                  60                  


Ala Val Phe Arg Phe Leu Phe Gly Phe Leu Met Val Leu Asp Ile Pro 
65                  70                  75                  80  


Gln Glu Arg Gly Leu Ser Ser Leu Asp Arg Lys Tyr Leu Asp Gly Leu 
                85                  90                  95      


Asp Val Cys Arg Phe Pro Leu Leu Asp Ala Leu Arg Pro Leu Pro Leu 
            100                 105                 110         


Asp Trp Met Tyr Leu Val Tyr Thr Ile Met Phe Leu Gly Ala Leu Gly 
        115                 120                 125             


Met Met Leu Gly Leu Cys Tyr Arg Ile Ser Cys Val Leu Phe Leu Leu 
    130                 135                 140                 


Pro Tyr Trp Tyr Val Phe Leu Leu Asp Lys Thr Ser Trp Asn Asn His 
145                 150                 155                 160 


Ser Tyr Leu Tyr Gly Leu Leu Ala Phe Gln Leu Thr Phe Met Asp Ala 
                165                 170                 175     


Asn His Tyr Trp Ser Val Asp Gly Leu Leu Asn Ala His Arg Arg Asn 
            180                 185                 190         


Ala His Val Pro Leu Trp Asn Tyr Ala Val Leu Arg Gly Gln Ile Phe 
        195                 200                 205             


Ile Val Tyr Phe Ile Ala Gly Val Lys Lys Leu Asp Ala Asp Trp Val 
    210                 215                 220                 


Glu Gly Tyr Ser Met Glu Tyr Leu Ser Arg His Trp Leu Phe Ser Pro 
225                 230                 235                 240 


Phe Lys Leu Leu Leu Ser Glu Glu Leu Thr Ser Leu Leu Val Val His 
                245                 250                 255     


Trp Gly Gly Leu Leu Leu Asp Leu Ser Ala Gly Phe Leu Leu Phe Phe 
            260                 265                 270         


Asp Val Ser Arg Ser Ile Gly Leu Phe Phe Val Ser Tyr Phe His Cys 
        275                 280                 285             


Met Asn Ser Gln Leu Phe Ser Ile Gly Met Phe Ser Tyr Val Met Leu 
    290                 295                 300                 


Ala Ser Ser Pro Leu Phe Cys Ser Pro Glu Trp Pro Arg Lys Leu Val 
305                 310                 315                 320 


Ser Tyr Cys Pro Arg Arg Leu Gln Gln Leu Leu Pro Leu Lys Ala Ala 
                325                 330                 335     


Pro Gln Pro Ser Val Ser Cys Val Tyr Lys Arg Ser Arg Gly Lys Ser 
            340                 345                 350         


Gly Gln Lys Pro Gly Leu Arg His Gln Leu Gly Ala Ala Phe Thr Leu 
        355                 360                 365             


Leu Tyr Leu Leu Glu Gln Leu Phe Leu Pro Tyr Ser His Phe Leu Thr 
    370                 375                 380                 


Gln Gly Tyr Asn Asn Trp Thr Asn Gly Leu Tyr Gly Tyr Ser Trp Asp 
385                 390                 395                 400 


Met Met Val His Ser Arg Ser His Gln His Val Lys Ile Thr Tyr Arg 
                405                 410                 415     


Asp Gly Arg Thr Gly Glu Leu Gly Tyr Leu Asn Pro Gly Val Phe Thr 
            420                 425                 430         


Gln Ser Arg Arg Trp Lys Asp His Ala Asp Met Leu Lys Gln Tyr Ala 
        435                 440                 445             


Thr Cys Leu Ser Arg Leu Leu Pro Lys Tyr Asn Val Thr Glu Pro Gln 
    450                 455                 460                 


Ile Tyr Phe Asp Ile Trp Val Ser Ile Asn Asp Arg Phe Gln Gln Arg 
465                 470                 475                 480 


Ile Phe Asp Pro Arg Val Asp Ile Val Gln Ala Ala Trp Ser Pro Phe 
                485                 490                 495     


Gln Arg Thr Ser Trp Val Gln Pro Leu Leu Met Asp Leu Ser Pro Trp 
            500                 505                 510         


Arg Ala Lys Leu Gln Glu Ile Lys Ser Ser Leu Asp Asn His Thr Glu 
        515                 520                 525             


Val Val Phe Ile Ala Asp Phe Pro Gly Leu His Leu Glu Asn Phe Val 
    530                 535                 540                 


Ser Glu Asp Leu Gly Asn Thr Ser Ile Gln Leu Leu Gln Gly Glu Val 
545                 550                 555                 560 


Thr Val Glu Leu Val Ala Glu Gln Lys Asn Gln Thr Leu Arg Glu Gly 
                565                 570                 575     


Glu Lys Met Gln Leu Pro Ala Gly Glu Tyr His Lys Val Tyr Thr Thr 
            580                 585                 590         


Ser Pro Ser Pro Ser Cys Tyr Met Tyr Val Tyr Val Asn Thr Thr Glu 
        595                 600                 605             


Leu Ala Leu Glu Gln Asp Leu Ala Tyr Leu Gln Glu Leu Lys Glu Lys 
    610                 615                 620                 


Val Glu Asn Gly Ser Glu Thr Gly Pro Leu Pro Pro Glu Leu Gln Pro 
625                 630                 635                 640 


Leu Leu Glu Gly Glu Val Lys Gly Gly Pro Glu Pro Thr Pro Leu Val 
                645                 650                 655     


Gln Thr Phe Leu Arg Arg Gln Gln Arg Leu Gln Glu Ile Glu Arg Arg 
            660                 665                 670         


Arg Asn Thr Pro Phe His Glu Arg Phe Phe Arg Phe Leu Leu Arg Lys 
        675                 680                 685             


Leu Tyr Val Phe Arg Arg Ser Phe Leu Met Thr Cys Ile Ser Leu Arg 
    690                 695                 700                 


Asn Leu Ile Leu Gly Arg Pro Ser Leu Glu Gln Leu Ala Gln Glu Val 
705                 710                 715                 720 


Thr Tyr Ala Asn Leu Arg Pro Phe Glu Ala Val Gly Glu Leu Asn Pro 
                725                 730                 735     


Ser Asn Thr Asp Ser Ser His Ser Asn Pro Pro Glu Ser Asn Pro Asp 
            740                 745                 750         


Pro Val His Ser Glu Phe 
        755             


<210>  4432
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGH__Homo_sapiens__NP_003869

<400>  4432

Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys 
            20                  25                  30          


Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met 
        35                  40                  45              


Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu 
    50                  55                  60                  


Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu 
65                  70                  75                  80  


Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro 
                85                  90                  95      


Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys 
            100                 105                 110         


Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe 
        115                 120                 125             


Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile 
    130                 135                 140                 


Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met 
145                 150                 155                 160 


Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn 
                165                 170                 175     


Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala 
            180                 185                 190         


Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu 
        195                 200                 205             


Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys 
    210                 215                 220                 


Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly 
225                 230                 235                 240 


Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp 
                245                 250                 255     


Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala 
            260                 265                 270         


Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser 
        275                 280                 285             


Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp 
305                 310                 315             


<210>  4433
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGNBP2__Homo_sapiens__NP_079111

<400>  4433

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met 
            20                  25                  30          


Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn 
        35                  40                  45              


Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys 
    50                  55                  60                  


Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu 
65                  70                  75                  80  


Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val 
                85                  90                  95      


Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu 
            100                 105                 110         


Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys 
        115                 120                 125             


Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser 
    130                 135                 140                 


Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys Asn Lys 
145                 150                 155                 160 


Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu Gly 
                165                 170                 175     


Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys Arg Asp 
            180                 185                 190         


Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu Thr 
        195                 200                 205             


Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val Leu 
    210                 215                 220                 


Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys Glu Lys 
225                 230                 235                 240 


Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His Glu 
                245                 250                 255     


Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His Leu Leu 
            260                 265                 270         


Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Arg Arg Glu Arg His Ala 
        275                 280                 285             


Lys Thr Ile Asp Ile Ala Gln Glu Glu Val Leu Thr Cys Leu Gly Ile 
    290                 295                 300                 


His Leu Tyr Glu Arg Leu His Arg Ile Trp Gln Lys Leu Arg Ala Glu 
305                 310                 315                 320 


Glu Gln Thr Trp Gln Met Leu Phe Tyr Leu Gly Val Asp Ala Leu Arg 
                325                 330                 335     


Lys Ser Phe Glu Met Thr Val Glu Lys Val Gln Gly Ile Ser Arg Leu 
            340                 345                 350         


Glu Gln Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val Arg Glu Leu 
        355                 360                 365             


Lys Gln Glu Lys Lys Arg Gln Lys Arg Lys Asn Arg Arg Lys Asn Lys 
    370                 375                 380                 


Cys Val Cys Asp Ile Pro Thr Pro Leu Gln Thr Ala Asp Glu Lys Glu 
385                 390                 395                 400 


Val Ser Gln Glu Lys Glu Thr Asp Phe Ile Glu Asn Ser Ser Cys Lys 
                405                 410                 415     


Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu Val Ile Val 
            420                 425                 430         


Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly Asn Leu Leu 
        435                 440                 445             


Gly Ser Pro Lys Ile Lys Lys Gly Leu Ser Pro His Cys Asn Gly Ser 
    450                 455                 460                 


Asp Cys Gly Tyr Ser Ser Ser Met Glu Gly Ser Glu Thr Gly Ser Arg 
465                 470                 475                 480 


Glu Gly Ser Asp Val Ala Cys Thr Glu Gly Ile Cys Asn His Asp Glu 
                485                 490                 495     


His Gly Asp Asp Ser Cys Val His His Cys Glu Asp Lys Glu Asp Asp 
            500                 505                 510         


Gly Asp Ser Cys Val Glu Cys Trp Ala Asn Ser Glu Glu Asn Asp Thr 
        515                 520                 525             


Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys Ile Leu Lys Cys 
    530                 535                 540                 


Asp Glu His Ile Gln Lys Leu Gly Ser Cys Ile Thr Asp Pro Gly Asn 
545                 550                 555                 560 


Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His Arg Asp Lys 
                565                 570                 575     


Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu Lys Gly Gly 
            580                 585                 590         


Gln Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro Gln Phe Ala 
        595                 600                 605             


Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys Gly Ala Lys 
    610                 615                 620                 


Ser Leu Val Glu Leu Leu Asp Glu Ser Glu Cys Thr Ser Asp Glu Glu 
625                 630                 635                 640 


Ile Phe Ile Ser Gln Asp Glu Ile Gln Ser Phe Met Ala Asn Asn Gln 
                645                 650                 655     


Ser Phe Tyr Ser Asn Arg Glu Gln Tyr Arg Gln His Leu Lys Glu Lys 
            660                 665                 670         


Phe Asn Lys Tyr Cys Arg Leu Asn Asp His Lys Arg Pro Ile Cys Ser 
        675                 680                 685             


Gly Trp Leu Thr Thr Ala Gly Ala Asn 
    690                 695         


<210>  4434
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGN__Homo_sapiens__NP_689870

<400>  4434

Met Gly Asn Leu Gln Ser Glu Pro Ser Ala Gly Gly Gly Ser Arg Lys 
1               5                   10                  15      


Val Gln Pro Ser Asp Arg Ala Pro Asp Ser Arg Arg Thr Ser Leu Val 
            20                  25                  30          


Glu Pro Glu Met Thr Ser Gln Ala Met Arg Leu Thr Arg Gly Leu Gly 
        35                  40                  45              


Val Trp Phe Pro Gly Ser Ala Thr Pro Pro Gly Leu Met Val Pro Arg 
    50                  55                  60                  


Glu Pro Gln Ala Ser Pro Ser Thr Leu Pro Leu Thr Leu Glu Arg Pro 
65                  70                  75                  80  


Ser Pro Val Met Pro Pro Pro Glu Glu Ala Ala Ala Val Ser Ala Pro 
                85                  90                  95      


Pro Pro Ala Pro Ala Gly Thr Leu Leu Pro Gly Pro Ser Lys Trp Gln 
            100                 105                 110         


Lys Pro Ala Gly Thr Pro Val Pro Arg Ile Arg Arg Leu Leu Glu Ala 
        115                 120                 125             


Ser His Arg Gly Gln Gly Asp Pro Pro Ser Leu Arg Pro Leu Lys Pro 
    130                 135                 140                 


Pro Pro Pro Pro Arg Gln Leu Ser Val Lys Asp Thr Val Pro Arg Ala 
145                 150                 155                 160 


Pro Ser Gln Phe Pro Pro Pro Leu Glu Thr Trp Lys Pro Pro Pro Pro 
                165                 170                 175     


Leu Pro Ser Glu Arg Gln Pro Ala Asp Arg Arg Ile Thr Pro Ala Leu 
            180                 185                 190         


Ala Thr Pro Ala Ser Pro Pro Thr Glu Ser Gln Ala Gly Pro Arg Asn 
        195                 200                 205             


Gln Gly Gln Thr Ala Gly Arg Ala Arg Gly Gly Ala Pro Pro His Ala 
    210                 215                 220                 


Gly Glu Gly Glu Met Ala Gln Pro Ala Asp Ser Glu Ser Gly Leu Ser 
225                 230                 235                 240 


Leu Leu Cys Lys Ile Thr Phe Lys Ser Arg Pro Ser Leu Ala Pro Pro 
                245                 250                 255     


Ala Ala Ser Ser Ser Leu Ala Ala Lys Ala Ser Leu Gly Gly Gly Gly 
            260                 265                 270         


Gly Gly Gly Leu Phe Ala Ala Ser Gly Ala Ile Ser Tyr Ala Glu Val 
        275                 280                 285             


Leu Lys Gln Gly Pro Leu Pro Pro Gly Ala Ala Arg Pro Leu Gly Glu 
    290                 295                 300                 


Val Ser Arg Gly Ala Gln Glu Ala Glu Gly Gly Asp Gly Asp Gly Glu 
305                 310                 315                 320 


Gly Cys Ser Gly Pro Pro Ser Ala Pro Ala Ser Gln Ala Arg Ala Leu 
                325                 330                 335     


Pro Pro Pro Pro Tyr Thr Thr Phe Pro Gly Ser Lys Pro Lys Phe Asp 
            340                 345                 350         


Trp Val Ser Ala Pro Asp Gly Pro Glu Arg His Phe Arg Phe Asn Gly 
        355                 360                 365             


Ala Gly Gly Gly Ile Gly Ala Pro Arg Arg Arg Ala Ala Ala Leu Ser 
    370                 375                 380                 


Gly Pro Trp Gly Ser Pro Pro Pro Pro Pro Glu Gln Ile His Ser Ala 
385                 390                 395                 400 


Pro Gly Pro Arg Arg Pro Ala Pro Ala Leu Leu Ala Pro Pro Thr Phe 
                405                 410                 415     


Ile Phe Pro Ala Pro Thr Asn Gly Glu Pro Met Arg Pro Gly Pro Pro 
            420                 425                 430         


Gly Leu Gln Glu Leu Pro Pro Leu Pro Pro Pro Thr Pro Pro Pro Thr 
        435                 440                 445             


Leu Gln Pro Pro Ala Leu Gln Pro Thr Pro Leu Pro Val Ala Pro Pro 
    450                 455                 460                 


Leu Thr Pro Gly Leu Gly His Lys Glu Ser Ala Leu Ala Pro Thr Ala 
465                 470                 475                 480 


Ala Pro Ala Leu Pro Pro Ala Leu Ala Ala Asp Gln Ala Pro Ala Pro 
                485                 490                 495     


Ser Pro Ala Pro Ala Pro Thr Val Ala Glu Pro Ser Pro Pro Val Ser 
            500                 505                 510         


Ala Pro Ala Pro Ala Ala Ala Pro Ile Lys Thr Arg Thr Arg Arg Asn 
        515                 520                 525             


Lys Gly Ser Arg Ala Ala Arg Gly Ala Thr Arg Lys Asp Gly Leu His 
    530                 535                 540                 


Gly Asp Gly Pro Arg Glu Arg Ala Thr Ala Thr Val Pro Asp Ser Ser 
545                 550                 555                 560 


Gly Gly Gly Gly Gly Gly Ser Gly Ala Ser Gln Thr Gly Ala Ala Asn 
                565                 570                 575     


Thr Arg Ala Ala Arg His Trp Leu Pro Phe Gln Val Leu Asn Ser Cys 
            580                 585                 590         


Pro Cys Lys Cys Tyr Cys His His Gln Pro Arg His Arg Arg Leu Pro 
        595                 600                 605             


Arg Asn Val Ser Ala Trp Leu Ser Thr Ser Thr Asn His Leu Gly Glu 
    610                 615                 620                 


Pro Pro Trp Val Ala Thr Ile Lys Leu Ser Gly Ser Leu Val Ala Lys 
625                 630                 635                 640 


Leu Glu His Tyr Asp Leu Gln Ala Thr His Ser Asn 
                645                 650         


<210>  4435
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGPS1__Homo_sapiens__NP_001032354

<400>  4435

Met Glu Lys Thr Gln Glu Thr Val Gln Arg Ile Leu Leu Glu Pro Tyr 
1               5                   10                  15      


Lys Tyr Leu Leu Gln Leu Pro Gly Lys Gln Val Arg Thr Lys Leu Ser 
            20                  25                  30          


Gln Ala Phe Asn His Trp Leu Lys Val Pro Glu Asp Lys Leu Gln Ile 
        35                  40                  45              


Ile Ile Glu Val Thr Glu Met Leu His Asn Ala Ser Leu Leu Ile Asp 
    50                  55                  60                  


Asp Ile Glu Asp Asn Ser Lys Leu Arg Arg Gly Phe Pro Val Ala His 
65                  70                  75                  80  


Ser Ile Tyr Gly Ile Pro Ser Val Ile Asn Ser Ala Asn Tyr Val Tyr 
                85                  90                  95      


Phe Leu Gly Leu Glu Lys Val Leu Thr Leu Asp His Pro Asp Ala Val 
            100                 105                 110         


Lys Leu Phe Thr Arg Gln Leu Leu Glu Leu His Gln Gly Gln Gly Leu 
        115                 120                 125             


Asp Ile Tyr Trp Arg Asp Asn Tyr Thr Cys Pro Thr Glu Glu Glu Tyr 
    130                 135                 140                 


Lys Ala Met Val Leu Gln Lys Thr Gly Gly Leu Phe Gly Leu Ala Val 
145                 150                 155                 160 


Gly Leu Met Gln Leu Phe Ser Asp Tyr Lys Glu Asp Leu Lys Pro Leu 
                165                 170                 175     


Leu Asn Thr Leu Gly Leu Phe Phe Gln Ile Arg Asp Asp Tyr Ala Asn 
            180                 185                 190         


Leu His Ser Lys Glu Tyr Ser Glu Asn Lys Ser Phe Cys Glu Asp Leu 
        195                 200                 205             


Thr Glu Gly Lys Phe Ser Phe Pro Thr Ile His Ala Ile Trp Ser Arg 
    210                 215                 220                 


Pro Glu Ser Thr Gln Val Gln Asn Ile Leu Arg Gln Arg Thr Glu Asn 
225                 230                 235                 240 


Ile Asp Ile Lys Lys Tyr Cys Val His Tyr Leu Glu Asp Val Gly Ser 
                245                 250                 255     


Phe Glu Tyr Thr Arg Asn Thr Leu Lys Glu Leu Glu Ala Lys Ala Tyr 
            260                 265                 270         


Lys Gln Ile Asp Ala Arg Gly Gly Asn Pro Glu Leu Val Ala Leu Val 
        275                 280                 285             


Lys His Leu Ser Lys Met Phe Lys Glu Glu Asn Glu 
    290                 295                 300 


<210>  4436
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGT1__Homo_sapiens__NP_038347

<400>  4436

Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val 
1               5                   10                  15      


Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu 
            20                  25                  30          


Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys 
        35                  40                  45              


Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala 
    50                  55                  60                  


Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala 
65                  70                  75                  80  


His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser 
                85                  90                  95      


Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg 
            100                 105                 110         


Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly 
        115                 120                 125             


Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala 
    130                 135                 140                 


His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser 
145                 150                 155                 160 


Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala 
                165                 170                 175     


Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys 
            180                 185                 190         


Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu 
        195                 200                 205             


Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly 
    210                 215                 220                 


Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp 
225                 230                 235                 240 


Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr 
                245                 250                 255     


Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val 
            260                 265                 270         


Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu 
        275                 280                 285             


Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu 
    290                 295                 300                 


Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe 
305                 310                 315                 320 


Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val 
                325                 330                 335     


Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala 
            340                 345                 350         


Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr 
        355                 360                 365             


Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu 
    370                 375                 380                 


Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile 
385                 390                 395                 400 


Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu 
                405                 410                 415     


Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu 
            420                 425                 430         


Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln 
        435                 440                 445             


Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly Gln 
    450                 455                 460                 


Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile Thr Thr Ala 
465                 470                 475                 480 


Thr Ala Leu Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val Lys 
                485                 490                 495     


Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Val 
            500                 505                 510         


Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu Glu 
        515                 520                 525             


Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val Val 
    530                 535                 540                 


Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp Ser 
545                 550                 555                 560 


Arg Lys Gly Gly Glu Pro Ala Gly Tyr 
                565                 


<210>  4437
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGT2__Homo_sapiens__XP_011528923

<400>  4437

Met Thr Ser Glu Phe Phe Ala Ala Gln Leu Arg Ser Gln Ile Ser Asp 
1               5                   10                  15      


His Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Thr Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Cys Ser Pro Val Ser Gly Ile Leu Phe Asn Asn Glu Trp Thr Thr Ser 
65                  70                  75                  80  


Ala Leu Pro Ala Phe Thr Asn Glu Phe Gly Ala Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Leu Ser Met Cys Leu Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Thr Asp Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140                 


Leu Trp Phe Gly Tyr Asp Val Lys Arg Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160 


His Asn Lys Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175     


Gln Ala Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190         


Ala Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Thr Ala Gly 
        195                 200                 205             


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220                 


Tyr 
225 


<210>  4438
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGT5__Homo_sapiens__NP_001093251

<400>  4438

Met Ala Arg Gly Tyr Gly Ala Thr Val Ser Leu Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Leu Ala Leu Ala Val Ile Val Leu Ala Val Val Leu Ser Arg His 
            20                  25                  30          


Gln Ala Pro Cys Gly Pro Gln Ala Phe Ala His Ala Ala Val Ala Ala 
        35                  40                  45              


Asp Ser Lys Val Cys Ser Asp Ile Gly Arg Ala Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gly Ser Pro Val Asp Ala Thr Ile Ala Ala Leu Val Cys Thr Ser Val 
65                  70                  75                  80  


Val Asn Pro Gln Ser Met Gly Leu Gly Gly Gly Val Ile Phe Thr Ile 
                85                  90                  95      


Tyr Asn Val Thr Thr Gly Lys Val Glu Val Ile Asn Ala Arg Glu Thr 
            100                 105                 110         


Val Pro Ala Ser His Ala Pro Ser Leu Leu Asp Gln Cys Ala Gln Ala 
        115                 120                 125             


Leu Pro Leu Gly Thr Gly Ala Gln Trp Ile Gly Val Pro Gly Glu Leu 
    130                 135                 140                 


Arg Gly Tyr Ala Glu Ala His Arg Arg His Gly Arg Leu Pro Trp Ala 
145                 150                 155                 160 


Gln Leu Phe Gln Pro Thr Ile Ala Leu Leu Arg Gly Gly His Val Val 
                165                 170                 175     


Ala Pro Val Leu Ser Arg Phe Leu His Asn Ser Ile Leu Arg Pro Ser 
            180                 185                 190         


Leu Gln Ala Ser Thr Leu Arg Gln Leu Phe Phe Asn Gly Thr Glu Pro 
        195                 200                 205             


Leu Arg Pro Gln Asp Pro Leu Pro Trp Pro Ala Leu Ala Thr Thr Leu 
    210                 215                 220                 


Glu Thr Val Ala Thr Glu Gly Val Glu Val Phe Tyr Thr Gly Arg Leu 
225                 230                 235                 240 


Gly Gln Met Leu Val Glu Asp Ile Ala Lys Glu Gly Ser Gln Leu Thr 
                245                 250                 255     


Leu Gln Asp Leu Ala Lys Phe Gln Pro Glu Val Val Asp Ala Leu Glu 
            260                 265                 270         


Val Pro Leu Gly Asp Tyr Thr Leu Tyr Ser Pro Pro Pro Pro Ala Gly 
        275                 280                 285             


Gly Ala Ile Leu Ser Phe Ile Leu Asn Val Leu Arg Gly Phe Asn Phe 
    290                 295                 300                 


Ser Thr Glu Ser Met Ala Arg Pro Glu Gly Arg Val Asn Val Tyr His 
305                 310                 315                 320 


His Leu Val Glu Thr Leu Lys Phe Ala Lys Gly Gln Arg Trp Arg Leu 
                325                 330                 335     


Gly Asp Pro Arg Ser His Pro Lys Leu Gln Asn Ala Ser Arg Asp Leu 
            340                 345                 350         


Leu Gly Glu Thr Leu Ala Gln Leu Ile Arg Gln Gln Ile Asp Gly Arg 
        355                 360                 365             


Gly Asp His Gln Leu Ser His Tyr Ser Leu Ala Glu Ala Trp Gly His 
    370                 375                 380                 


Gly Thr Gly Thr Ser His Val Ser Val Leu Gly Glu Asp Gly Ser Ala 
385                 390                 395                 400 


Val Ala Ala Thr Ser Thr Ile Asn Thr Pro Phe Gly Ala Met Val Tyr 
                405                 410                 415     


Ser Pro Arg Thr Gly Ile Ile Leu Asn Asn Glu Leu Leu Asp Leu Cys 
            420                 425                 430         


Glu Arg Cys Pro Arg Gly Ser Gly Thr Thr Pro Ser Pro Ala Val Ser 
        435                 440                 445             


Gly Asp Arg Val Gly Gly Ala Pro Gly Arg Cys Trp Pro Pro Val Pro 
    450                 455                 460                 


Gly Glu Arg Ser Pro Ser Ser Met Val Pro Ser Ile Leu Ile Asn Lys 
465                 470                 475                 480 


Ala Gln Gly Ser Lys Leu Val Ile Gly Gly Ala Gly Gly Glu Leu Ile 
                485                 490                 495     


Ile Ser Ala Val Ala Gln Ala Ile Met Ser Lys Leu Trp Leu Gly Phe 
            500                 505                 510         


Asp Leu Arg Ala Ala Ile Ala Ala Pro Ile Leu His Val Asn Ser Lys 
        515                 520                 525             


Gly Cys Val Glu Tyr Glu Pro Asn Phe Ser Gln Glu Val Gln Arg Gly 
    530                 535                 540                 


Leu Gln Asp Arg Gly Gln Asn Gln Thr Gln Arg Pro Phe Phe Leu Asn 
545                 550                 555                 560 


Val Val Gln Ala Val Ser Gln Glu Gly Ala Cys Val Tyr Ala Val Ser 
                565                 570                 575     


Asp Leu Arg Lys Ser Gly Glu Ala Ala Gly Tyr 
            580                 585         


<210>  4439
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGTLC1__Homo_sapiens__XP_005260922

<400>  4439

Met Thr Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15      


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 
            20                  25                  30          


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45              


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60                  


Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80  


Ser Ser Thr Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95      


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110         


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140                 


Leu Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160 


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175     


Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190         


Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Met Ala Gly 
        195                 200                 205             


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220                 


Tyr 
225 


<210>  4440
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GH1__Homo_sapiens__NP_000506

<400>  4440

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  4441
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GH2__Homo_sapiens__NP_002050

<400>  4441

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Leu Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Trp Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Asn Gln Ser Tyr Ser Lys Phe Asp Thr Lys Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  4442
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHITM__Homo_sapiens__NP_055209

<400>  4442

Met Leu Ala Ala Arg Leu Val Cys Leu Arg Thr Leu Pro Ser Arg Val 
1               5                   10                  15      


Phe His Pro Ala Phe Thr Lys Ala Ser Pro Val Val Lys Asn Ser Ile 
            20                  25                  30          


Thr Lys Asn Gln Trp Leu Leu Thr Pro Ser Arg Glu Tyr Ala Thr Lys 
        35                  40                  45              


Thr Arg Ile Gly Ile Arg Arg Gly Arg Thr Gly Gln Glu Leu Lys Glu 
    50                  55                  60                  


Ala Ala Leu Glu Pro Ser Met Glu Lys Ile Phe Lys Ile Asp Gln Met 
65                  70                  75                  80  


Gly Arg Trp Phe Val Ala Gly Gly Ala Ala Val Gly Leu Gly Ala Leu 
                85                  90                  95      


Cys Tyr Tyr Gly Leu Gly Leu Ser Asn Glu Ile Gly Ala Ile Glu Lys 
            100                 105                 110         


Ala Val Ile Trp Pro Gln Tyr Val Lys Asp Arg Ile His Ser Thr Tyr 
        115                 120                 125             


Met Tyr Leu Ala Gly Ser Ile Gly Leu Thr Ala Leu Ser Ala Ile Ala 
    130                 135                 140                 


Ile Ser Arg Thr Pro Val Leu Met Asn Phe Met Met Arg Gly Ser Trp 
145                 150                 155                 160 


Val Thr Ile Gly Val Thr Phe Ala Ala Met Val Gly Ala Gly Met Leu 
                165                 170                 175     


Val Arg Ser Ile Pro Tyr Asp Gln Ser Pro Gly Pro Lys His Leu Ala 
            180                 185                 190         


Trp Leu Leu His Ser Gly Val Met Gly Ala Val Val Ala Pro Leu Thr 
        195                 200                 205             


Ile Leu Gly Gly Pro Leu Leu Ile Arg Ala Ala Trp Tyr Thr Ala Gly 
    210                 215                 220                 


Ile Val Gly Gly Leu Ser Thr Val Ala Met Cys Ala Pro Ser Glu Lys 
225                 230                 235                 240 


Phe Leu Asn Met Gly Ala Pro Leu Gly Val Gly Leu Gly Leu Val Phe 
                245                 250                 255     


Val Ser Ser Leu Gly Ser Met Phe Leu Pro Pro Thr Thr Val Ala Gly 
            260                 265                 270         


Ala Thr Leu Tyr Ser Val Ala Met Tyr Gly Gly Leu Val Leu Phe Ser 
        275                 280                 285             


Met Phe Leu Leu Tyr Asp Thr Gln Lys Val Ile Lys Arg Ala Glu Val 
    290                 295                 300                 


Ser Pro Met Tyr Gly Val Gln Lys Tyr Asp Pro Ile Asn Ser Met Leu 
305                 310                 315                 320 


Ser Ile Tyr Met Asp Thr Leu Asn Ile Phe Met Arg Val Ala Thr Met 
                325                 330                 335     


Leu Ala Thr Gly Gly Asn Arg Lys Lys 
            340                 345 


<210>  4443
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHRH__Homo_sapiens__XP_011527089

<400>  4443

Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu Gly Arg Gln Val Asp 
65                  70                  75                  80  


Ser Met Trp Ala Glu Gln Lys Gln Met Glu Leu Glu Ser Ile Leu Val 
                85                  90                  95      


Ala Leu Leu Gln Lys His Ser Arg Asn Ser Gln Gly 
            100                 105             


<210>  4444
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHR__Homo_sapiens__NP_001229328

<400>  4444

Met Asn Trp Gly Pro Thr Gly Met Asp Leu Trp Gln Leu Leu Leu Thr 
1               5                   10                  15      


Leu Ala Leu Ala Gly Ser Ser Asp Ala Phe Ser Gly Ser Glu Ala Thr 
            20                  25                  30          


Ala Ala Ile Leu Ser Arg Ala Pro Trp Ser Leu Gln Ser Val Asn Pro 
        35                  40                  45              


Gly Leu Lys Thr Asn Ser Ser Lys Glu Pro Lys Phe Thr Lys Cys Arg 
    50                  55                  60                  


Ser Pro Glu Arg Glu Thr Phe Ser Cys His Trp Thr Asp Glu Val His 
65                  70                  75                  80  


His Gly Thr Lys Asn Leu Gly Pro Ile Gln Leu Phe Tyr Thr Arg Arg 
                85                  90                  95      


Asn Thr Gln Glu Trp Thr Gln Glu Trp Lys Glu Cys Pro Asp Tyr Val 
            100                 105                 110         


Ser Ala Gly Glu Asn Ser Cys Tyr Phe Asn Ser Ser Phe Thr Ser Ile 
        115                 120                 125             


Trp Ile Pro Tyr Cys Ile Lys Leu Thr Ser Asn Gly Gly Thr Val Asp 
    130                 135                 140                 


Glu Lys Cys Phe Ser Val Asp Glu Ile Val Gln Pro Asp Pro Pro Ile 
145                 150                 155                 160 


Ala Leu Asn Trp Thr Leu Leu Asn Val Ser Leu Thr Gly Ile His Ala 
                165                 170                 175     


Asp Ile Gln Val Arg Trp Glu Ala Pro Arg Asn Ala Asp Ile Gln Lys 
            180                 185                 190         


Gly Trp Met Val Leu Glu Tyr Glu Leu Gln Tyr Lys Glu Val Asn Glu 
        195                 200                 205             


Thr Lys Trp Lys Met Met Asp Pro Ile Leu Thr Thr Ser Val Pro Val 
    210                 215                 220                 


Tyr Ser Leu Lys Val Asp Lys Glu Tyr Glu Val Arg Val Arg Ser Lys 
225                 230                 235                 240 


Gln Arg Asn Ser Gly Asn Tyr Gly Glu Phe Ser Glu Val Leu Tyr Val 
                245                 250                 255     


Thr Leu Pro Gln Met Ser Gln Phe Thr Cys Glu Glu Asp Phe Tyr Phe 
            260                 265                 270         


Pro Trp Leu Leu Ile Ile Ile Phe Gly Ile Phe Gly Leu Thr Val Met 
        275                 280                 285             


Leu Phe Val Phe Leu Phe Ser Lys Gln Gln Arg Ile Lys Met Leu Ile 
    290                 295                 300                 


Leu Pro Pro Val Pro Val Pro Lys Ile Lys Gly Ile Asp Pro Asp Leu 
305                 310                 315                 320 


Leu Lys Glu Gly Lys Leu Glu Glu Val Asn Thr Ile Leu Ala Ile His 
                325                 330                 335     


Asp Ser Tyr Lys Pro Glu Phe His Ser Asp Asp Ser Trp Val Glu Phe 
            340                 345                 350         


Ile Glu Leu Asp Ile Asp Glu Pro Asp Glu Lys Thr Glu Glu Ser Asp 
        355                 360                 365             


Thr Asp Arg Leu Leu Ser Ser Asp His Glu Lys Ser His Ser Asn Leu 
    370                 375                 380                 


Gly Val Lys Asp Gly Asp Ser Gly Arg Thr Ser Cys Cys Glu Pro Asp 
385                 390                 395                 400 


Ile Leu Glu Thr Asp Phe Asn Ala Asn Asp Ile His Glu Gly Thr Ser 
                405                 410                 415     


Glu Val Ala Gln Pro Gln Arg Leu Lys Gly Glu Ala Asp Leu Leu Cys 
            420                 425                 430         


Leu Asp Gln Lys Asn Gln Asn Asn Ser Pro Tyr His Asp Ala Cys Pro 
        435                 440                 445             


Ala Thr Gln Gln Pro Ser Val Ile Gln Ala Glu Lys Asn Lys Pro Gln 
    450                 455                 460                 


Pro Leu Pro Thr Glu Gly Ala Glu Ser Thr His Gln Ala Ala His Ile 
465                 470                 475                 480 


Gln Leu Ser Asn Pro Ser Ser Leu Ser Asn Ile Asp Phe Tyr Ala Gln 
                485                 490                 495     


Val Ser Asp Ile Thr Pro Ala Gly Ser Val Val Leu Ser Pro Gly Gln 
            500                 505                 510         


Lys Asn Lys Ala Gly Met Ser Gln Cys Asp Met His Pro Glu Met Val 
        515                 520                 525             


Ser Leu Cys Gln Glu Asn Phe Leu Met Asp Asn Ala Tyr Phe Cys Glu 
    530                 535                 540                 


Ala Asp Ala Lys Lys Cys Ile Pro Val Ala Pro His Ile Lys Val Glu 
545                 550                 555                 560 


Ser His Ile Gln Pro Ser Leu Asn Gln Glu Asp Ile Tyr Ile Thr Thr 
                565                 570                 575     


Glu Ser Leu Thr Thr Ala Ala Gly Arg Pro Gly Thr Gly Glu His Val 
            580                 585                 590         


Pro Gly Ser Glu Met Pro Val Pro Asp Tyr Thr Ser Ile His Ile Val 
        595                 600                 605             


Gln Ser Pro Gln Gly Leu Ile Leu Asn Ala Thr Ala Leu Pro Leu Pro 
    610                 615                 620                 


Asp Lys Glu Phe Leu Ser Ser Cys Gly Tyr Val Ser Thr Asp Gln Leu 
625                 630                 635                 640 


Asn Lys Ile Met Pro 
                645 


<210>  4445
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHRHR__Homo_sapiens__NP_000814

<400>  4445

Met Asp Arg Arg Met Trp Gly Ala His Val Phe Cys Val Leu Ser Pro 
1               5                   10                  15      


Leu Pro Thr Val Leu Gly His Met His Pro Glu Cys Asp Phe Ile Thr 
            20                  25                  30          


Gln Leu Arg Glu Asp Glu Ser Ala Cys Leu Gln Ala Ala Glu Glu Met 
        35                  40                  45              


Pro Asn Thr Thr Leu Gly Cys Pro Ala Thr Trp Asp Gly Leu Leu Cys 
    50                  55                  60                  


Trp Pro Thr Ala Gly Ser Gly Glu Trp Val Thr Leu Pro Cys Pro Asp 
65                  70                  75                  80  


Phe Phe Ser His Phe Ser Ser Glu Ser Gly Ala Val Lys Arg Asp Cys 
                85                  90                  95      


Thr Ile Thr Gly Trp Ser Glu Pro Phe Pro Pro Tyr Pro Val Ala Cys 
            100                 105                 110         


Pro Val Pro Leu Glu Leu Leu Ala Glu Glu Glu Ser Tyr Phe Ser Thr 
        115                 120                 125             


Val Lys Ile Ile Tyr Thr Val Gly His Ser Ile Ser Ile Val Ala Leu 
    130                 135                 140                 


Phe Val Ala Ile Thr Ile Leu Val Ala Leu Arg Arg Leu His Cys Pro 
145                 150                 155                 160 


Arg Asn Tyr Val His Thr Gln Leu Phe Thr Thr Phe Ile Leu Lys Ala 
                165                 170                 175     


Gly Ala Val Phe Leu Lys Asp Ala Ala Leu Phe His Ser Asp Asp Thr 
            180                 185                 190         


Asp His Cys Ser Phe Ser Thr Val Leu Cys Lys Val Ser Val Ala Ala 
        195                 200                 205             


Ser His Phe Ala Thr Met Thr Asn Phe Ser Trp Leu Leu Ala Glu Ala 
    210                 215                 220                 


Val Tyr Leu Asn Cys Leu Leu Ala Ser Thr Ser Pro Ser Ser Arg Arg 
225                 230                 235                 240 


Ala Phe Trp Trp Leu Val Leu Ala Gly Trp Gly Leu Pro Val Leu Phe 
                245                 250                 255     


Thr Gly Thr Trp Val Ser Cys Lys Leu Ala Phe Glu Asp Ile Ala Cys 
            260                 265                 270         


Trp Asp Leu Asp Asp Thr Ser Pro Tyr Trp Trp Ile Ile Lys Gly Pro 
        275                 280                 285             


Ile Val Leu Ser Val Gly Val Asn Phe Gly Leu Phe Leu Asn Ile Ile 
    290                 295                 300                 


Arg Ile Leu Val Arg Lys Leu Glu Pro Ala Gln Gly Ser Leu His Thr 
305                 310                 315                 320 


Gln Ser Gln Tyr Trp Arg Leu Ser Lys Ser Thr Leu Phe Leu Ile Pro 
                325                 330                 335     


Leu Phe Gly Ile His Tyr Ile Ile Phe Asn Phe Leu Pro Asp Asn Ala 
            340                 345                 350         


Gly Leu Gly Ile Arg Leu Pro Leu Glu Leu Gly Leu Gly Ser Phe Gln 
        355                 360                 365             


Gly Phe Ile Val Ala Ile Leu Tyr Cys Phe Leu Asn Gln Glu Val Arg 
    370                 375                 380                 


Thr Glu Ile Ser Arg Lys Trp His Gly His Asp Pro Glu Leu Leu Pro 
385                 390                 395                 400 


Ala Trp Arg Thr Arg Ala Lys Trp Thr Thr Pro Ser Arg Ser Ala Ala 
                405                 410                 415     


Lys Val Leu Thr Ser Met Cys 
            420             


<210>  4446
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHRL__Homo_sapiens__NP_001128416

<400>  4446

Met Phe Thr Cys Trp Trp Ser Tyr Leu Arg Ser Thr Leu Ala Ala Val 
1               5                   10                  15      


Pro Gly Glu Ala Ser Arg Val Gln Gln Arg Lys Glu Ser Lys Lys Pro 
            20                  25                  30          


Pro Ala Lys Leu Gln Pro Arg Ala Leu Ala Gly Trp Leu Arg Pro Glu 
        35                  40                  45              


Asp Gly Gly Gln Ala Glu Gly Ala Glu Asp Glu Leu Glu Val Arg Phe 
    50                  55                  60                  


Asn Ala Pro Phe Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr Gln 
65                  70                  75                  80  


Gln His Ser Gln Ala Leu Gly Lys Phe Leu Gln Asp Ile Leu Trp Glu 
                85                  90                  95      


Glu Ala Lys Glu Ala Pro Ala Asp Lys 
            100                 105 


<210>  4447
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GHSR__Homo_sapiens__NP_004113

<400>  4447

Met Trp Asn Ala Thr Pro Ser Glu Glu Pro Gly Phe Asn Leu Thr Leu 
1               5                   10                  15      


Ala Asp Leu Asp Trp Asp Ala Ser Pro Gly Asn Asp Ser Leu Gly Asp 
            20                  25                  30          


Glu Leu Leu Gln Leu Phe Pro Ala Pro Leu Leu Ala Gly Val Thr Ala 
        35                  40                  45              


Thr Cys Val Ala Leu Phe Val Val Gly Ile Ala Gly Asn Leu Leu Thr 
    50                  55                  60                  


Met Leu Val Val Ser Arg Phe Arg Glu Leu Arg Thr Thr Thr Asn Leu 
65                  70                  75                  80  


Tyr Leu Ser Ser Met Ala Phe Ser Asp Leu Leu Ile Phe Leu Cys Met 
                85                  90                  95      


Pro Leu Asp Leu Val Arg Leu Trp Gln Tyr Arg Pro Trp Asn Phe Gly 
            100                 105                 110         


Asp Leu Leu Cys Lys Leu Phe Gln Phe Val Ser Glu Ser Cys Thr Tyr 
        115                 120                 125             


Ala Thr Val Leu Thr Ile Thr Ala Leu Ser Val Glu Arg Tyr Phe Ala 
    130                 135                 140                 


Ile Cys Phe Pro Leu Arg Ala Lys Val Val Val Thr Lys Gly Arg Val 
145                 150                 155                 160 


Lys Leu Val Ile Phe Val Ile Trp Ala Val Ala Phe Cys Ser Ala Gly 
                165                 170                 175     


Pro Ile Phe Val Leu Val Gly Val Glu His Glu Asn Gly Thr Asp Pro 
            180                 185                 190         


Trp Asp Thr Asn Glu Cys Arg Pro Thr Glu Phe Ala Val Arg Ser Gly 
        195                 200                 205             


Leu Leu Thr Val Met Val Trp Val Ser Ser Ile Phe Phe Phe Leu Pro 
    210                 215                 220                 


Val Phe Cys Leu Thr Val Leu Tyr Ser Leu Ile Gly Arg Lys Leu Trp 
225                 230                 235                 240 


Arg Arg Arg Arg Gly Asp Ala Val Val Gly Ala Ser Leu Arg Asp Gln 
                245                 250                 255     


Asn His Lys Gln Thr Val Lys Met Leu Gly Gly Ser Gln Arg Ala Leu 
            260                 265                 270         


Arg Leu Ser Leu Ala Gly Pro Ile Leu Ser Leu Cys Leu Leu Pro Ser 
        275                 280                 285             


Leu 
    


<210>  4448
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GID8__Homo_sapiens__NP_060366

<400>  4448

Met Ser Tyr Ala Glu Lys Pro Asp Glu Ile Thr Lys Asp Glu Trp Met 
1               5                   10                  15      


Glu Lys Leu Asn Asn Leu His Val Gln Arg Ala Asp Met Asn Arg Leu 
            20                  25                  30          


Ile Met Asn Tyr Leu Val Thr Glu Gly Phe Lys Glu Ala Ala Glu Lys 
        35                  40                  45              


Phe Arg Met Glu Ser Gly Ile Glu Pro Ser Val Asp Leu Glu Thr Leu 
    50                  55                  60                  


Asp Glu Arg Ile Lys Ile Arg Glu Met Ile Leu Lys Gly Gln Ile Gln 
65                  70                  75                  80  


Glu Ala Ile Ala Leu Ile Asn Ser Leu His Pro Glu Leu Leu Asp Thr 
                85                  90                  95      


Asn Arg Tyr Leu Tyr Phe His Leu Gln Gln Gln His Leu Ile Glu Leu 
            100                 105                 110         


Ile Arg Gln Arg Glu Thr Glu Ala Ala Leu Glu Phe Ala Gln Thr Gln 
        115                 120                 125             


Leu Ala Glu Gln Gly Glu Glu Ser Arg Glu Cys Leu Thr Glu Met Glu 
    130                 135                 140                 


Arg Thr Leu Ala Leu Leu Ala Phe Asp Ser Pro Glu Glu Ser Pro Phe 
145                 150                 155                 160 


Gly Asp Leu Leu His Thr Met Gln Arg Gln Lys Val Trp Ser Glu Val 
                165                 170                 175     


Asn Gln Ala Val Leu Asp Tyr Glu Asn Arg Glu Ser Thr Pro Lys Leu 
            180                 185                 190         


Ala Lys Leu Leu Lys Leu Leu Leu Trp Ala Gln Asn Glu Leu Asp Gln 
        195                 200                 205             


Lys Lys Val Lys Tyr Pro Lys Met Thr Asp Leu Ser Lys Gly Val Ile 
    210                 215                 220                 


Glu Glu Pro Lys 
225             


<210>  4449
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIF__Homo_sapiens__NP_005133

<400>  4449

Met Ala Trp Phe Ala Leu Tyr Leu Leu Ser Leu Leu Trp Ala Thr Ala 
1               5                   10                  15      


Gly Thr Ser Thr Gln Thr Gln Ser Ser Cys Ser Val Pro Ser Ala Gln 
            20                  25                  30          


Glu Pro Leu Val Asn Gly Ile Gln Val Leu Met Glu Asn Ser Val Thr 
        35                  40                  45              


Ser Ser Ala Tyr Pro Asn Pro Ser Ile Leu Ile Ala Met Asn Leu Ala 
    50                  55                  60                  


Gly Ala Tyr Asn Leu Lys Ala Gln Lys Leu Leu Thr Tyr Gln Leu Met 
65                  70                  75                  80  


Ser Ser Asp Asn Asn Asp Leu Thr Ile Gly Gln Leu Gly Leu Thr Ile 
                85                  90                  95      


Met Ala Leu Thr Ser Ser Cys Arg Asp Pro Gly Asp Lys Val Ser Ile 
            100                 105                 110         


Leu Gln Arg Gln Met Glu Asn Trp Ala Pro Ser Ser Pro Asn Ala Glu 
        115                 120                 125             


Ala Ser Ala Phe Tyr Gly Pro Ser Leu Ala Ile Leu Ala Leu Cys Gln 
    130                 135                 140                 


Lys Asn Ser Glu Ala Thr Leu Pro Ile Ala Val Arg Phe Ala Lys Thr 
145                 150                 155                 160 


Leu Leu Ala Asn Ser Ser Pro Phe Asn Val Asp Thr Gly Ala Met Ala 
                165                 170                 175     


Thr Leu Ala Leu Thr Cys Met Tyr Asn Lys Ile Pro Val Gly Ser Glu 
            180                 185                 190         


Glu Gly Tyr Arg Ser Leu Phe Gly Gln Val Leu Lys Asp Ile Val Glu 
        195                 200                 205             


Lys Ile Ser Met Lys Ile Lys Asp Asn Gly Ile Ile Gly Asp Ile Tyr 
    210                 215                 220                 


Ser Thr Gly Leu Ala Met Gln Ala Leu Ser Val Thr Pro Glu Pro Ser 
225                 230                 235                 240 


Lys Lys Glu Trp Asn Cys Lys Lys Thr Thr Asp Met Ile Leu Asn Glu 
                245                 250                 255     


Ile Lys Gln Gly Lys Phe His Asn Pro Met Ser Ile Ala Gln Ile Leu 
            260                 265                 270         


Pro Ser Leu Lys Gly Lys Thr Tyr Leu Asp Val Pro Gln Val Thr Cys 
        275                 280                 285             


Ser Pro Asp His Glu Val Gln Pro Thr Leu Pro Ser Asn Pro Gly Pro 
    290                 295                 300                 


Gly Pro Thr Ser Ala Ser Asn Ile Thr Val Ile Tyr Thr Ile Asn Asn 
305                 310                 315                 320 


Gln Leu Arg Gly Val Glu Leu Leu Phe Asn Glu Thr Ile Asn Val Ser 
                325                 330                 335     


Val Lys Ser Gly Ser Val Leu Leu Val Val Leu Glu Glu Ala Gln Arg 
            340                 345                 350         


Lys Asn Pro Met Phe Lys Phe Glu Thr Thr Met Thr Ser Trp Gly Leu 
        355                 360                 365             


Val Val Ser Ser Ile Asn Asn Ile Ala Glu Asn Val Asn His Lys Thr 
    370                 375                 380                 


Tyr Trp Gln Phe Leu Ser Gly Val Thr Pro Leu Asn Glu Gly Val Ala 
385                 390                 395                 400 


Asp Tyr Ile Pro Phe Asn His Glu His Ile Thr Ala Asn Phe Thr Gln 
                405                 410                 415     


Tyr 
    


<210>  4450
<211>  1035
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIGYF1__Homo_sapiens__XP_005250589

<400>  4450

Met Ala Ala Glu Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg Ala Leu 
1               5                   10                  15      


Ser Gly Gly Gly Ser Val Ala Ser Pro Pro Pro Ser Pro Ala Met Pro 
            20                  25                  30          


Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met Leu Ala 
        35                  40                  45              


Leu Tyr Val Lys Glu Asn Lys Val Pro Glu Glu Leu Gln Asp Lys Glu 
    50                  55                  60                  


Phe Ala Ala Val Leu Gln Asp Glu Pro Leu Gln Pro Leu Ala Leu Glu 
65                  70                  75                  80  


Pro Leu Thr Glu Glu Glu Gln Arg Asn Phe Ser Leu Ser Val Asn Ser 
                85                  90                  95      


Val Ala Val Leu Arg Leu Met Gly Lys Gly Ala Gly Pro Pro Leu Ala 
            100                 105                 110         


Gly Thr Ser Arg Gly Arg Gly Ser Thr Arg Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Asp Ser Cys Phe Tyr Gln Arg Ser Ile Glu Glu Gly Asp Gly Ala 
    130                 135                 140                 


Phe Gly Arg Ser Pro Arg Glu Ile Gln Arg Ser Gln Ser Trp Asp Asp 
145                 150                 155                 160 


Arg Gly Glu Arg Arg Phe Glu Lys Ser Ala Arg Arg Asp Gly Ala Arg 
                165                 170                 175     


Cys Gly Phe Glu Glu Gly Gly Ala Gly Pro Arg Lys Glu His Ala Arg 
            180                 185                 190         


Ser Asp Ser Glu Asn Trp Arg Ser Leu Arg Glu Glu Gln Glu Glu Glu 
        195                 200                 205             


Glu Glu Gly Ser Trp Arg Leu Gly Ala Gly Pro Arg Arg Asp Gly Asp 
    210                 215                 220                 


Arg Trp Arg Ser Ala Ser Pro Asp Gly Gly Pro Arg Ser Ala Gly Trp 
225                 230                 235                 240 


Arg Glu His Gly Glu Arg Arg Arg Lys Phe Glu Phe Asp Leu Arg Gly 
                245                 250                 255     


Asp Arg Gly Gly Cys Gly Glu Glu Glu Gly Arg Gly Gly Gly Gly Ser 
            260                 265                 270         


Ser His Leu Arg Arg Cys Arg Ala Pro Glu Gly Phe Glu Glu Asp Lys 
        275                 280                 285             


Asp Gly Leu Pro Glu Trp Cys Leu Asp Asp Glu Asp Glu Glu Met Gly 
    290                 295                 300                 


Thr Phe Asp Ala Ser Gly Ala Phe Leu Pro Leu Lys Lys Gly Pro Lys 
305                 310                 315                 320 


Glu Pro Ile Pro Glu Glu Gln Glu Leu Asp Phe Gln Gly Leu Glu Glu 
                325                 330                 335     


Glu Glu Glu Pro Ser Glu Gly Leu Glu Glu Glu Gly Pro Glu Ala Gly 
            340                 345                 350         


Gly Lys Glu Leu Thr Pro Leu Pro Pro Gln Glu Glu Lys Ser Ser Ser 
        355                 360                 365             


Pro Ser Pro Leu Pro Thr Leu Gly Pro Leu Trp Gly Thr Asn Gly Asp 
    370                 375                 380                 


Gly Asp Glu Thr Ala Glu Lys Glu Pro Pro Ala Ala Glu Asp Asp Ile 
385                 390                 395                 400 


Arg Gly Ile Gln Leu Ser Pro Gly Val Gly Ser Ser Ala Gly Pro Pro 
                405                 410                 415     


Gly Asp Leu Glu Asp Asp Glu Gly Leu Lys His Leu Gln Gln Glu Ala 
            420                 425                 430         


Glu Lys Leu Val Ala Ser Leu Gln Asp Ser Ser Leu Glu Glu Glu Gln 
        435                 440                 445             


Phe Thr Ala Ala Met Gln Thr Gln Gly Leu Arg His Ser Ala Ala Ala 
    450                 455                 460                 


Thr Ala Leu Pro Leu Ser His Gly Ala Ala Arg Lys Trp Phe Tyr Lys 
465                 470                 475                 480 


Asp Pro Gln Gly Glu Ile Gln Gly Pro Phe Thr Thr Gln Glu Met Ala 
                485                 490                 495     


Glu Trp Phe Gln Ala Gly Tyr Phe Ser Met Ser Leu Leu Val Lys Arg 
            500                 505                 510         


Gly Cys Asp Glu Gly Phe Gln Pro Leu Gly Glu Val Ile Lys Met Trp 
        515                 520                 525             


Gly Arg Val Pro Phe Ala Pro Gly Pro Ser Pro Pro Pro Leu Leu Gly 
    530                 535                 540                 


Asn Met Asp Gln Glu Arg Leu Lys Lys Gln Gln Glu Leu Ala Ala Ala 
545                 550                 555                 560 


Ala Leu Tyr Gln Gln Leu Gln His Gln Gln Phe Leu Gln Leu Val Ser 
                565                 570                 575     


Ser Arg Gln Leu Pro Gln Cys Ala Leu Arg Glu Lys Ala Ala Leu Gly 
            580                 585                 590         


Asp Leu Thr Pro Pro Pro Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln 
        595                 600                 605             


Leu Thr Ala Phe Leu Gln Gln Leu Gln Ala Leu Lys Pro Pro Arg Gly 
    610                 615                 620                 


Gly Asp Gln Asn Leu Leu Pro Thr Met Ser Arg Ser Leu Ser Val Pro 
625                 630                 635                 640 


Asp Ser Gly Arg Leu Trp Asp Val His Thr Ser Ala Ser Ser Gln Ser 
                645                 650                 655     


Gly Gly Glu Ala Ser Leu Trp Asp Ile Pro Ile Asn Ser Ser Thr Gln 
            660                 665                 670         


Gly Pro Ile Leu Glu Gln Leu Gln Leu Gln His Lys Phe Gln Glu Arg 
        675                 680                 685             


Arg Glu Val Glu Leu Arg Ala Lys Arg Glu Glu Glu Glu Arg Lys Arg 
    690                 695                 700                 


Arg Glu Glu Lys Arg Arg Gln Gln Gln Gln Glu Glu Gln Lys Arg Arg 
705                 710                 715                 720 


Gln Glu Glu Glu Glu Leu Phe Arg Arg Lys His Val Arg Gln Gln Glu 
                725                 730                 735     


Leu Leu Leu Lys Leu Leu Gln Gln Gln Gln Ala Val Pro Val Pro Pro 
            740                 745                 750         


Ala Pro Ser Ser Pro Pro Pro Leu Trp Ala Gly Leu Ala Lys Gln Gly 
        755                 760                 765             


Leu Ser Met Lys Thr Leu Leu Glu Leu Gln Leu Glu Gly Glu Arg Gln 
    770                 775                 780                 


Leu His Lys Gln Pro Pro Pro Arg Glu Pro Ala Arg Ala Gln Ala Pro 
785                 790                 795                 800 


Asn His Arg Val Gln Leu Gly Gly Leu Gly Thr Ala Pro Leu Asn Gln 
                805                 810                 815     


Trp Val Ser Glu Ala Gly Pro Leu Trp Gly Gly Pro Asp Lys Ser Gly 
            820                 825                 830         


Gly Gly Ser Ser Gly Leu Gly Leu Trp Glu Asp Thr Pro Lys Ser Gly 
        835                 840                 845             


Gly Ser Leu Val Arg Gly Leu Gly Leu Lys Asn Ser Arg Ser Ser Pro 
    850                 855                 860                 


Ser Leu Ser Asp Ser Tyr Ser His Leu Ser Gly Arg Pro Ile Arg Lys 
865                 870                 875                 880 


Lys Thr Glu Glu Glu Glu Lys Leu Leu Lys Leu Leu Gln Gly Ile Pro 
                885                 890                 895     


Arg Pro Gln Asp Gly Phe Thr Gln Trp Cys Glu Gln Met Leu His Thr 
            900                 905                 910         


Leu Ser Ala Thr Gly Ser Leu Asp Val Pro Met Ala Val Ala Ile Leu 
        915                 920                 925             


Lys Glu Val Glu Ser Pro Tyr Asp Val His Asp Tyr Ile Arg Ser Cys 
    930                 935                 940                 


Leu Gly Asp Thr Leu Glu Ala Lys Glu Phe Ala Lys Gln Phe Leu Glu 
945                 950                 955                 960 


Arg Arg Ala Lys Gln Lys Ala Ser Gln Gln Arg Gln Gln Gln Gln Glu 
                965                 970                 975     


Ala Trp Leu Ser Ser Ala Ser Leu Gln Thr Ala Phe Gln Ala Asn His 
            980                 985                 990         


Ser Thr Lys Leu Gly Pro Gly Glu  Gly Ser Lys Ala Lys  Arg Arg Ala 
        995                 1000                 1005             


Leu Met  Leu His Ser Asp Pro  Ser Ile Leu Gly Tyr  Ser Leu His 
    1010                 1015                 1020             


Gly Ser  Ser Gly Glu Ile Glu  Ser Val Asp Asp Tyr  
    1025                 1030                 1035 


<210>  4451
<211>  1299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIGYF2__Homo_sapiens__NP_001096616

<400>  4451

Met Ala Ala Glu Thr Gln Thr Leu Asn Phe Gly Pro Glu Trp Leu Arg 
1               5                   10                  15      


Ala Leu Ser Ser Gly Gly Ser Ile Thr Ser Pro Pro Leu Ser Pro Ala 
            20                  25                  30          


Leu Pro Lys Tyr Lys Leu Ala Asp Tyr Arg Tyr Gly Arg Glu Glu Met 
        35                  40                  45              


Leu Ala Leu Phe Leu Lys Asp Asn Lys Ile Pro Ser Asp Leu Leu Asp 
    50                  55                  60                  


Lys Glu Phe Leu Pro Ile Leu Gln Glu Glu Pro Leu Pro Pro Leu Ala 
65                  70                  75                  80  


Leu Val Pro Phe Thr Glu Glu Glu Gln Arg Asn Phe Ser Met Ser Val 
                85                  90                  95      


Asn Ser Ala Ala Val Leu Arg Leu Thr Gly Arg Gly Gly Gly Gly Thr 
            100                 105                 110         


Val Val Gly Ala Pro Arg Gly Arg Ser Ser Ser Arg Gly Arg Gly Arg 
        115                 120                 125             


Gly Arg Gly Glu Cys Gly Phe Tyr Gln Arg Ser Phe Asp Glu Val Glu 
    130                 135                 140                 


Gly Val Phe Gly Arg Gly Gly Gly Arg Glu Met His Arg Ser Gln Ser 
145                 150                 155                 160 


Trp Glu Glu Arg Gly Asp Arg Arg Phe Glu Lys Pro Gly Arg Lys Asp 
                165                 170                 175     


Val Gly Arg Pro Asn Phe Glu Glu Gly Gly Pro Thr Ser Val Gly Arg 
            180                 185                 190         


Lys His Glu Phe Ile Arg Ser Glu Ser Glu Asn Trp Arg Ile Phe Arg 
        195                 200                 205             


Glu Glu Gln Asn Gly Glu Asp Glu Asp Gly Gly Trp Arg Leu Ala Gly 
    210                 215                 220                 


Ser Arg Arg Asp Gly Glu Arg Trp Arg Pro His Ser Pro Asp Gly Pro 
225                 230                 235                 240 


Arg Ser Ala Gly Trp Arg Glu His Met Glu Arg Arg Arg Arg Phe Glu 
                245                 250                 255     


Phe Asp Phe Arg Asp Arg Asp Asp Glu Arg Gly Tyr Arg Arg Val Arg 
            260                 265                 270         


Ser Gly Ser Gly Ser Ile Asp Asp Asp Arg Asp Ser Leu Pro Glu Trp 
        275                 280                 285             


Cys Leu Glu Asp Ala Glu Glu Glu Met Gly Thr Phe Asp Ser Ser Gly 
    290                 295                 300                 


Ala Phe Leu Ser Leu Lys Lys Val Gln Lys Glu Pro Ile Pro Glu Glu 
305                 310                 315                 320 


Gln Glu Met Asp Phe Arg Pro Val Asp Glu Gly Glu Glu Cys Ser Asp 
                325                 330                 335     


Ser Glu Gly Ser His Asn Glu Glu Ala Lys Glu Pro Asp Lys Thr Asn 
            340                 345                 350         


Lys Lys Glu Gly Glu Lys Thr Asp Arg Val Gly Val Glu Ala Ser Glu 
        355                 360                 365             


Glu Thr Pro Gln Thr Ser Ser Ser Ser Ala Arg Pro Gly Thr Pro Ser 
    370                 375                 380                 


Asp His Gln Ser Gln Glu Ala Ser Gln Phe Glu Arg Lys Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Gln Thr Glu Lys Ala Glu Glu Glu Thr Arg Met Glu Asn 
                405                 410                 415     


Ser Leu Pro Ala Lys Val Pro Ser Arg Gly Asp Glu Met Val Ala Asp 
            420                 425                 430         


Val Gln Gln Pro Leu Ser Gln Ile Pro Ser Asp Thr Ala Ser Pro Leu 
        435                 440                 445             


Leu Ile Leu Pro Pro Pro Val Pro Asn Pro Ser Pro Thr Leu Arg Pro 
    450                 455                 460                 


Val Glu Thr Pro Val Val Gly Ala Pro Gly Met Gly Ser Val Ser Thr 
465                 470                 475                 480 


Glu Pro Asp Asp Glu Glu Gly Leu Lys His Leu Glu Gln Gln Ala Glu 
                485                 490                 495     


Lys Met Val Ala Tyr Leu Gln Asp Ser Ala Leu Asp Asp Glu Arg Leu 
            500                 505                 510         


Ala Ser Lys Leu Gln Glu His Arg Ala Lys Gly Val Ser Ile Pro Leu 
        515                 520                 525             


Met His Glu Ala Met Gln Lys Trp Tyr Tyr Lys Asp Pro Gln Gly Glu 
    530                 535                 540                 


Ile Gln Gly Pro Phe Asn Asn Gln Glu Met Ala Glu Trp Phe Gln Ala 
545                 550                 555                 560 


Gly Tyr Phe Thr Met Ser Leu Leu Val Lys Arg Ala Cys Asp Glu Ser 
                565                 570                 575     


Phe Gln Pro Leu Gly Asp Ile Met Lys Met Trp Gly Arg Val Pro Phe 
            580                 585                 590         


Ser Pro Gly Pro Ala Pro Pro Pro His Met Gly Glu Leu Asp Gln Glu 
        595                 600                 605             


Arg Leu Thr Arg Gln Gln Glu Leu Thr Ala Leu Tyr Gln Met Gln His 
    610                 615                 620                 


Leu Gln Tyr Gln Gln Phe Leu Ile Gln Gln Gln Tyr Ala Gln Val Leu 
625                 630                 635                 640 


Ala Gln Gln Gln Lys Ala Ala Leu Ser Ser Gln Gln Gln Gln Gln Leu 
                645                 650                 655     


Ala Leu Leu Leu Gln Gln Phe Gln Thr Leu Lys Met Arg Ile Ser Asp 
            660                 665                 670         


Gln Asn Ile Ile Pro Ser Val Thr Arg Ser Val Ser Val Pro Asp Thr 
        675                 680                 685             


Gly Ser Ile Trp Glu Leu Gln Pro Thr Ala Ser Gln Pro Thr Val Trp 
    690                 695                 700                 


Glu Gly Gly Ser Val Trp Asp Leu Pro Leu Asp Thr Thr Thr Pro Gly 
705                 710                 715                 720 


Pro Ala Leu Glu Gln Leu Gln Gln Leu Glu Lys Ala Lys Ala Ala Lys 
                725                 730                 735     


Leu Glu Gln Glu Arg Arg Glu Ala Glu Met Arg Ala Lys Arg Glu Glu 
            740                 745                 750         


Glu Glu Arg Lys Arg Gln Glu Glu Leu Arg Arg Gln Gln Glu Glu Ile 
        755                 760                 765             


Leu Arg Arg Gln Gln Glu Glu Glu Arg Lys Arg Arg Glu Glu Glu Glu 
    770                 775                 780                 


Leu Ala Arg Arg Lys Gln Glu Glu Ala Leu Arg Arg Gln Arg Glu Gln 
785                 790                 795                 800 


Glu Ile Ala Leu Arg Arg Gln Arg Glu Glu Glu Glu Arg Gln Gln Gln 
                805                 810                 815     


Glu Glu Ala Leu Arg Arg Leu Glu Glu Arg Arg Arg Glu Glu Glu Glu 
            820                 825                 830         


Arg Arg Lys Gln Glu Glu Leu Leu Arg Lys Gln Glu Glu Glu Ala Ala 
        835                 840                 845             


Lys Trp Ala Arg Glu Glu Glu Glu Ala Gln Arg Arg Leu Glu Glu Asn 
    850                 855                 860                 


Arg Leu Arg Met Glu Glu Glu Ala Ala Arg Leu Arg His Glu Glu Glu 
865                 870                 875                 880 


Glu Arg Lys Arg Lys Glu Leu Glu Val Gln Arg Gln Lys Glu Leu Met 
                885                 890                 895     


Arg Gln Arg Gln Gln Gln Gln Glu Ala Leu Arg Arg Leu Gln Gln Gln 
            900                 905                 910         


Gln Gln Gln Gln Gln Leu Ala Gln Met Lys Leu Pro Ser Ser Ser Thr 
        915                 920                 925             


Trp Gly Gln Gln Ser Asn Thr Thr Ala Cys Gln Ser Gln Ala Thr Leu 
    930                 935                 940                 


Ser Leu Ala Glu Ile Gln Lys Leu Glu Glu Glu Arg Glu Arg Gln Leu 
945                 950                 955                 960 


Arg Glu Glu Gln Arg Arg Gln Gln Arg Glu Leu Met Lys Ala Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Gln Gln Gln Gln Lys Leu Ser Gly Trp Gly Asn Val 
            980                 985                 990         


Ser Lys Pro Ser Gly Thr Thr Lys  Ser Leu Leu Glu Ile  Gln Gln Glu 
        995                 1000                 1005             


Glu Ala  Arg Gln Met Gln Lys  Gln Gln Gln Gln Gln  Gln Gln His 
    1010                 1015                 1020             


Gln Gln  Pro Asn Arg Ala Arg  Asn Asn Thr His Ser  Asn Leu His 
    1025                 1030                 1035             


Thr Ser  Ile Gly Asn Ser Val  Trp Gly Ser Ile Asn  Thr Gly Pro 
    1040                 1045                 1050             


Pro Asn  Gln Trp Ala Ser Asp  Leu Val Ser Ser Ile  Trp Ser Asn 
    1055                 1060                 1065             


Ala Asp  Thr Lys Asn Ser Asn  Met Gly Phe Trp Asp  Asp Ala Val 
    1070                 1075                 1080             


Lys Glu  Val Gly Pro Arg Asn  Ser Thr Asn Lys Asn  Lys Asn Asn 
    1085                 1090                 1095             


Ala Ser  Leu Ser Lys Ser Val  Gly Val Ser Asn Arg  Gln Asn Lys 
    1100                 1105                 1110             


Lys Val  Glu Glu Glu Glu Lys  Leu Leu Lys Leu Phe  Gln Gly Val 
    1115                 1120                 1125             


Asn Lys  Ala Gln Asp Gly Phe  Thr Gln Trp Cys Glu  Gln Met Leu 
    1130                 1135                 1140             


His Ala  Leu Asn Thr Ala Asn  Asn Leu Asp Val Pro  Thr Phe Val 
    1145                 1150                 1155             


Ser Phe  Leu Lys Glu Val Glu  Ser Pro Tyr Glu Val  His Asp Tyr 
    1160                 1165                 1170             


Ile Arg  Ala Tyr Leu Gly Asp  Thr Ser Glu Ala Lys  Glu Phe Ala 
    1175                 1180                 1185             


Lys Gln  Phe Leu Glu Arg Arg  Ala Lys Gln Lys Ala  Asn Gln Gln 
    1190                 1195                 1200             


Arg Gln  Gln Gln Gln Leu Pro  Gln Gln Gln Gln Gln  Gln Pro Pro 
    1205                 1210                 1215             


Gln Gln  Pro Pro Gln Gln Pro  Gln Gln Gln Asp Ser  Val Trp Gly 
    1220                 1225                 1230             


Met Asn  His Ser Thr Leu His  Ser Val Phe Gln Thr  Asn Gln Ser 
    1235                 1240                 1245             


Asn Asn  Gln Gln Ser Asn Phe  Glu Ala Val Gln Ser  Gly Lys Lys 
    1250                 1255                 1260             


Lys Lys  Lys Gln Lys Met Val  Arg Ala Asp Pro Ser  Leu Leu Gly 
    1265                 1270                 1275             


Phe Ser  Val Asn Ala Ser Ser  Glu Arg Leu Asn Met  Gly Glu Ile 
    1280                 1285                 1290             


Glu Thr  Leu Asp Asp Tyr 
    1295                 


<210>  4452
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIMAP5__Homo_sapiens__NP_060854

<400>  4452

Met Gly Gly Phe Gln Arg Gly Lys Tyr Gly Thr Met Ala Glu Gly Arg 
1               5                   10                  15      


Ser Glu Asp Asn Leu Ser Ala Thr Pro Pro Ala Leu Arg Ile Ile Leu 
            20                  25                  30          


Val Gly Lys Thr Gly Cys Gly Lys Ser Ala Thr Gly Asn Ser Ile Leu 
        35                  40                  45              


Gly Gln Pro Val Phe Glu Ser Lys Leu Arg Ala Gln Ser Val Thr Arg 
    50                  55                  60                  


Thr Cys Gln Val Lys Thr Gly Thr Trp Asn Gly Arg Lys Val Leu Val 
65                  70                  75                  80  


Val Asp Thr Pro Ser Ile Phe Glu Ser Gln Ala Asp Thr Gln Glu Leu 
                85                  90                  95      


Tyr Lys Asn Ile Gly Asp Cys Tyr Leu Leu Ser Ala Pro Gly Pro His 
            100                 105                 110         


Val Leu Leu Leu Val Ile Gln Leu Gly Arg Phe Thr Ala Gln Asp Thr 
        115                 120                 125             


Val Ala Ile Arg Lys Val Lys Glu Val Phe Gly Thr Gly Ala Met Arg 
    130                 135                 140                 


His Val Val Ile Leu Phe Thr His Lys Glu Asp Leu Gly Gly Gln Ala 
145                 150                 155                 160 


Leu Asp Asp Tyr Val Ala Asn Thr Asp Asn Cys Ser Leu Lys Asp Leu 
                165                 170                 175     


Val Arg Glu Cys Glu Arg Arg Tyr Cys Ala Phe Asn Asn Trp Gly Ser 
            180                 185                 190         


Val Glu Glu Gln Arg Gln Gln Gln Ala Glu Leu Leu Ala Val Ile Glu 
        195                 200                 205             


Arg Leu Gly Arg Glu Arg Glu Gly Ser Phe His Ser Asn Asp Leu Phe 
    210                 215                 220                 


Leu Asp Ala Gln Leu Leu Gln Arg Thr Gly Ala Gly Ala Cys Gln Glu 
225                 230                 235                 240 


Asp Tyr Arg Gln Tyr Gln Ala Lys Val Glu Trp Gln Val Glu Lys His 
                245                 250                 255     


Lys Gln Glu Leu Arg Glu Asn Glu Ser Asn Trp Ala Tyr Lys Ala Leu 
            260                 265                 270         


Leu Arg Val Lys His Leu Met Leu Leu His Tyr Glu Ile Phe Val Phe 
        275                 280                 285             


Leu Leu Leu Cys Ser Ile Leu Phe Phe Ile Ile Phe Leu Phe Ile Phe 
    290                 295                 300                 


His Tyr Ile 
305         


<210>  4453
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIMAP7__Homo_sapiens__NP_694968

<400>  4453

Met Ala Glu Ser Glu Asp Arg Ser Leu Arg Ile Val Leu Val Gly Lys 
1               5                   10                  15      


Thr Gly Ser Gly Lys Ser Ala Thr Ala Asn Thr Ile Leu Gly Glu Glu 
            20                  25                  30          


Ile Phe Asp Ser Arg Ile Ala Ala Gln Ala Val Thr Lys Asn Cys Gln 
        35                  40                  45              


Lys Ala Ser Arg Glu Trp Gln Gly Arg Asp Leu Leu Val Val Asp Thr 
    50                  55                  60                  


Pro Gly Leu Phe Asp Thr Lys Glu Ser Leu Asp Thr Thr Cys Lys Glu 
65                  70                  75                  80  


Ile Ser Arg Cys Ile Ile Ser Ser Cys Pro Gly Pro His Ala Ile Val 
                85                  90                  95      


Leu Val Leu Leu Leu Gly Arg Tyr Thr Glu Glu Glu Gln Lys Thr Val 
            100                 105                 110         


Ala Leu Ile Lys Ala Val Phe Gly Lys Ser Ala Met Lys His Met Val 
        115                 120                 125             


Ile Leu Phe Thr Arg Lys Glu Glu Leu Glu Gly Gln Ser Phe His Asp 
    130                 135                 140                 


Phe Ile Ala Asp Ala Asp Val Gly Leu Lys Ser Ile Val Lys Glu Cys 
145                 150                 155                 160 


Gly Asn Arg Cys Cys Ala Phe Ser Asn Ser Lys Lys Thr Ser Lys Ala 
                165                 170                 175     


Glu Lys Glu Ser Gln Val Gln Glu Leu Val Glu Leu Ile Glu Lys Met 
            180                 185                 190         


Val Gln Cys Asn Glu Gly Ala Tyr Phe Ser Asp Asp Ile Tyr Lys Asp 
        195                 200                 205             


Thr Glu Glu Arg Leu Lys Gln Arg Glu Glu Val Leu Arg Lys Ile Tyr 
    210                 215                 220                 


Thr Asp Gln Leu Asn Glu Glu Ile Lys Leu Val Glu Glu Asp Lys His 
225                 230                 235                 240 


Lys Ser Glu Glu Glu Lys Glu Lys Glu Ile Lys Leu Leu Lys Leu Lys 
                245                 250                 255     


Tyr Asp Glu Lys Ile Lys Asn Ile Arg Glu Glu Ala Glu Arg Asn Ile 
            260                 265                 270         


Phe Lys Asp Val Phe Asn Arg Ile Trp Lys Met Leu Ser Glu Ile Trp 
        275                 280                 285             


His Arg Phe Leu Ser Lys Cys Lys Phe Tyr Ser Ser 
    290                 295                 300 


<210>  4454
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIMAP8__Homo_sapiens__XP_005250007

<400>  4454

Met Ser Glu Gln Ser Cys Gln Met Ser Glu Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Gly Lys Cys Arg Ser Gly Lys Ser Ala Thr Gly Asn Ala Ile Leu Gly 
            20                  25                  30          


Lys His Val Phe Lys Ser Lys Phe Ser Asp Gln Thr Val Ile Lys Met 
        35                  40                  45              


Cys Gln Arg Glu Ser Trp Val Leu Arg Glu Arg Lys Val Val Val Ile 
    50                  55                  60                  


Asp Thr Pro Asp Leu Phe Ser Ser Ile Ala Cys Ala Glu Asp Lys Gln 
65                  70                  75                  80  


Arg Asn Ile Gln His Cys Leu Glu Leu Ser Ala Pro Ser Leu His Ala 
                85                  90                  95      


Leu Leu Leu Val Ile Ala Ile Gly His Phe Thr Arg Glu Asp Glu Glu 
            100                 105                 110         


Thr Ala Lys Gly Ile Gln Gln Val Phe Gly Ala Glu Ala Arg Arg His 
        115                 120                 125             


Ile Ile Ile Val Phe Thr Arg Lys Asp Asp Leu Gly Asp Asp Leu Leu 
    130                 135                 140                 


Gln Asp Phe Ile Glu Lys Asn Lys Pro Leu Lys Gln Leu Val Gln Asp 
145                 150                 155                 160 


Tyr Glu Gly Arg Tyr Cys Ile Phe Asn Asn Lys Thr Asn Ser Lys Asp 
                165                 170                 175     


Glu Gln Ile Thr Gln Val Leu Glu Leu Leu Arg Lys Val Glu Ser Leu 
            180                 185                 190         


Val Asn Thr Asn Gly Gly Pro Tyr His Val Asn Phe Lys Thr Glu Gly 
        195                 200                 205             


Ser Arg Phe Gln Asp Cys Val Asn Glu Ala Ala Ser Gln Glu Gly Asp 
    210                 215                 220                 


Lys Pro Gln Gly Pro Arg Glu Arg Gln Leu Gln Ser Thr Gly Pro Glu 
225                 230                 235                 240 


Gln Asn Pro Gly Thr Ser Glu Leu Thr Val Leu Leu Val Gly Lys Arg 
                245                 250                 255     


Gly Ala Gly Lys Ser Ala Ala Gly Asn Ser Ile Leu Gly Arg Gln Ala 
            260                 265                 270         


Phe Gln Thr Gly Phe Ser Glu Gln Ser Val Thr Gln Ser Phe Leu Ser 
        275                 280                 285             


Glu Ser Arg Ser Trp Arg Lys Lys Lys Val Ser Ile Ile Asp Ala Pro 
    290                 295                 300                 


Asp Ile Ser Ser Leu Lys Asn Ile Asp Ser Glu Val Arg Lys His Ile 
305                 310                 315                 320 


Cys Thr Gly Pro His Ala Phe Leu Leu Val Thr Pro Leu Gly Phe Tyr 
                325                 330                 335     


Thr Lys Asn Asp Glu Ala Val Leu Ser Thr Ile Gln Asn Asn Phe Gly 
            340                 345                 350         


Glu Lys Phe Phe Glu Tyr Met Ile Ile Leu Leu Thr Arg Lys Glu Asp 
        355                 360                 365             


Leu Gly Asp Gln Asp Leu Asp Thr Phe Leu Arg Asn Ser Asn Lys Ala 
    370                 375                 380                 


Leu Tyr Gly Leu Ile Gln Lys Cys Lys Asn Arg Tyr Ser Ala Phe Asn 
385                 390                 395                 400 


Tyr Arg Ala Thr Gly Glu Glu Glu Gln Arg Gln Ala Asp Glu Leu Leu 
                405                 410                 415     


Glu Lys Ile Glu Ser Met Val His Gln Asn Gly Asn Lys His Cys Val 
            420                 425                 430         


Phe Arg Glu Lys Glu Thr Leu Asn Ile Val Leu Val Gly Arg Ser Gly 
        435                 440                 445             


Thr Gly Lys Ser Ala Thr Gly Asn Ser Ile Leu Gly Ser Leu Val Phe 
    450                 455                 460                 


Thr Ser Arg Leu Arg Ala Gln Pro Val Thr Lys Thr Ser Gln Ser Gly 
465                 470                 475                 480 


Arg Arg Thr Trp Asp Gly Gln Glu Val Val Val Val Asp Thr Pro Ser 
                485                 490                 495     


Phe Asn Gln Met Leu Asp Val Glu Lys Asp Pro Ser Arg Leu Glu Glu 
            500                 505                 510         


Glu Val Lys Arg Cys Leu Ser Cys Cys Glu Lys Gly Asp Thr Phe Phe 
        515                 520                 525             


Val Leu Val Phe Gln Leu Gly Arg Phe Thr Glu Glu Asp Lys Thr Ala 
    530                 535                 540                 


Val Ala Lys Leu Glu Ala Ile Phe Gly Ala Asp Phe Thr Lys Tyr Ala 
545                 550                 555                 560 


Ile Met Leu Phe Thr Arg Lys Glu Asp Leu Gly Ala Gly Asn Leu Glu 
                565                 570                 575     


Asp Phe Met Lys Asn Ser Asp Asn Lys Ala Leu Arg Arg Ile Phe Lys 
            580                 585                 590         


Lys Cys Gly Arg Arg Val Cys Ala Phe Asn Asn Lys Glu Thr Gly Gln 
        595                 600                 605             


Ala Gln Glu Thr Gln Val Lys Ala Leu Leu Thr Lys Val Asn Asp Leu 
    610                 615                 620                 


Arg Lys Glu Ser Gly Trp Ser Gly Tyr Pro His Thr Gln Glu Asn Val 
625                 630                 635                 640 


Ser Lys Leu Ile Lys Asn Val Gln Glu Met Ser Gln Ala Glu Lys Leu 
                645                 650                 655     


Leu Lys Asn Leu Ile Gly Ile Leu Gln 
            660                 665 


<210>  4455
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIN1__Homo_sapiens__NP_060146

<400>  4455

Met Val Arg Ser Gly Lys Asn Gly Asp Leu His Leu Lys Gln Ile Ala 
1               5                   10                  15      


Tyr Tyr Lys Arg Thr Gly Glu Tyr His Ser Thr Thr Leu Pro Ser Glu 
            20                  25                  30          


Arg Ser Gly Ile Arg Arg Ala Ala Lys Lys Phe Val Phe Lys Glu Lys 
        35                  40                  45              


Lys Leu Phe Tyr Val Gly Lys Asp Arg Lys Gln Asn Arg Leu Val Ile 
    50                  55                  60                  


Val Ser Glu Glu Glu Lys Lys Lys Val Leu Arg Glu Cys His Glu Asn 
65                  70                  75                  80  


Asp Ser Gly Ala His His Gly Ile Ser Arg Thr Leu Thr Leu Val Glu 
                85                  90                  95      


Ser Asn Tyr Tyr Trp Thr Ser Val Thr Asn Asp Val Lys Gln Trp Val 
            100                 105                 110         


Tyr Ala Cys Gln His Cys Gln Val Ala Lys Asn Thr Val Ile Val Ala 
        115                 120                 125             


Pro Lys Gln His Leu Leu Lys Val Glu Asn Pro Trp Ser Leu Val Thr 
    130                 135                 140                 


Val Asp Leu Met Gly Pro Phe His Thr Ser Asn Arg Ser His Val Tyr 
145                 150                 155                 160 


Ala Ile Ile Met Thr Asp Leu Phe Thr Lys Trp Ile Val Ile Leu Pro 
                165                 170                 175     


Leu Cys Asp Val Ser Ala Ser Glu Val Ser Lys Ala Ile Ile Asn Ile 
            180                 185                 190         


Phe Phe Leu Tyr Gly Pro Pro Gln Lys Ile Ile Met Asp Gln Arg Asp 
        195                 200                 205             


Glu Phe Ile Gln Gln Ile Asn Ile Glu Leu Tyr Arg Leu Phe Gly Ile 
    210                 215                 220                 


Lys Gln Ile Val Ile Ser His Thr Ser Gly Thr Val Asn Pro Thr Glu 
225                 230                 235                 240 


Ser Thr Pro Asn Thr Ile Lys Ala Phe Leu Ser Lys His Cys Ala Asp 
                245                 250                 255     


His Pro Asn Asn Trp Asp Asp His Leu Ser Ala Val Ser Phe Ala Phe 
            260                 265                 270         


Asn Val Thr His Leu Glu Pro Thr Lys Asn Thr Pro Tyr Phe Gln Met 
        275                 280                 285             


Phe Ser Arg Asn Pro Tyr Met Pro Glu Thr Ser Asp Ser Leu His Glu 
    290                 295                 300                 


Val Asp Gly Asp Asn Thr Ser Met Phe Ala Lys Ile Leu Asp Ala Ile 
305                 310                 315                 320 


Lys Glu Ala Asp Lys Ile Met Glu Asn Lys Thr Thr Ser Leu Gly Gln 
                325                 330                 335     


Met Glu Asn Asn Asn Leu Asp Glu Leu Asn Lys Ser Lys Ile Ile Val 
            340                 345                 350         


Lys Lys Lys Pro Lys Gln Leu Asn Pro Phe His Leu Lys Val Gly His 
        355                 360                 365             


Glu Val Leu Arg Gln Arg Lys Asn Trp Trp Lys Asp Gly Arg Phe Gln 
    370                 375                 380                 


Ser Glu Trp Val Gly Pro Cys Val Ile Asp Tyr Ile Thr Glu Ser Gly 
385                 390                 395                 400 


Cys Ala Val Leu Arg Asp Asn Thr Gly Val Arg Leu Lys Arg Pro Ile 
                405                 410                 415     


Lys Met Ser His Leu Lys Pro Tyr Ile Arg Glu Ser Ser Glu Gln Glu 
            420                 425                 430         


Ser Leu Tyr Leu Leu Gln Gly Ser Val Val Ala Asp His Asp Tyr Ile 
        435                 440                 445             


Gly Leu Pro Glu Ile Pro Ile Gly Ala Tyr Gln Ala Asn Ile Leu Val 
    450                 455                 460                 


Glu Asp Ala Thr Ile Gly Ile Val Asp Asn Glu Leu Leu Thr Ser Ser 
465                 470                 475                 480 


Lys Asp Arg Glu Leu Leu Glu Tyr Arg Asn Thr Lys Ile Ser Pro Leu 
                485                 490                 495     


Ile Asp Asp His Ser Ser Leu Glu Lys Gln Thr Phe Ser Leu Leu Asp 
            500                 505                 510         


Ser Ser Asn Gln Val Leu Glu Tyr Leu Ser 
        515                 520         


<210>  4456
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GINS1__Homo_sapiens__NP_066545

<400>  4456

Met Phe Cys Glu Lys Ala Met Glu Leu Ile Arg Glu Leu His Arg Ala 
1               5                   10                  15      


Pro Glu Gly Gln Leu Pro Ala Phe Asn Glu Asp Gly Leu Arg Gln Val 
            20                  25                  30          


Leu Glu Glu Met Lys Ala Leu Tyr Glu Gln Asn Gln Ser Asp Val Asn 
        35                  40                  45              


Glu Ala Lys Ser Gly Gly Arg Ser Asp Leu Ile Pro Thr Ile Lys Phe 
    50                  55                  60                  


Arg His Cys Ser Leu Leu Arg Asn Arg Arg Cys Thr Val Ala Tyr Leu 
65                  70                  75                  80  


Tyr Asp Arg Leu Leu Arg Ile Arg Ala Leu Arg Trp Glu Tyr Gly Ser 
                85                  90                  95      


Val Leu Pro Asn Ala Leu Arg Phe His Met Ala Ala Glu Glu Met Glu 
            100                 105                 110         


Trp Phe Asn Asn Tyr Lys Arg Ser Leu Ala Thr Tyr Met Arg Ser Leu 
        115                 120                 125             


Gly Gly Asp Glu Gly Leu Asp Ile Thr Gln Asp Met Lys Pro Pro Lys 
    130                 135                 140                 


Ser Leu Tyr Ile Glu Val Arg Cys Leu Lys Asp Tyr Gly Glu Phe Glu 
145                 150                 155                 160 


Val Asp Asp Gly Thr Ser Val Leu Leu Lys Lys Asn Ser Gln His Phe 
                165                 170                 175     


Leu Pro Arg Trp Lys Cys Glu Gln Leu Ile Arg Gln Gly Val Leu Glu 
            180                 185                 190         


His Ile Leu Ser 
        195     


<210>  4457
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GINS2__Homo_sapiens__NP_057179

<400>  4457

Met Asp Ala Ala Glu Val Glu Phe Leu Ala Glu Lys Glu Leu Val Thr 
1               5                   10                  15      


Ile Ile Pro Asn Phe Ser Leu Asp Lys Ile Tyr Leu Ile Gly Gly Asp 
            20                  25                  30          


Leu Gly Pro Phe Asn Pro Gly Leu Pro Val Glu Val Pro Leu Trp Leu 
        35                  40                  45              


Ala Ile Asn Leu Lys Gln Arg Gln Lys Cys Arg Leu Leu Pro Pro Glu 
    50                  55                  60                  


Trp Met Asp Val Glu Lys Leu Glu Lys Met Arg Asp His Glu Arg Lys 
65                  70                  75                  80  


Glu Glu Thr Phe Thr Pro Met Pro Ser Pro Tyr Tyr Met Glu Leu Thr 
                85                  90                  95      


Lys Leu Leu Leu Asn His Ala Ser Asp Asn Ile Pro Lys Ala Asp Glu 
            100                 105                 110         


Ile Arg Thr Leu Val Lys Asp Met Trp Asp Thr Arg Ile Ala Lys Leu 
        115                 120                 125             


Arg Val Ser Ala Asp Ser Phe Val Arg Gln Gln Glu Ala His Ala Lys 
    130                 135                 140                 


Leu Asp Asn Leu Thr Leu Met Glu Ile Asn Thr Ser Gly Thr Phe Leu 
145                 150                 155                 160 


Thr Gln Ala Leu Asn His Met Tyr Lys Leu Arg Thr Asn Leu Gln Pro 
                165                 170                 175     


Leu Glu Ser Thr Gln Ser Gln Asp Phe 
            180                 185 


<210>  4458
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIPC1__Homo_sapiens__NP_005707

<400>  4458

Met Pro Leu Gly Leu Gly Arg Arg Lys Lys Ala Pro Pro Leu Val Glu 
1               5                   10                  15      


Asn Glu Glu Ala Glu Pro Gly Arg Gly Gly Leu Gly Val Gly Glu Pro 
            20                  25                  30          


Gly Pro Leu Gly Gly Gly Gly Ser Gly Gly Pro Gln Met Gly Leu Pro 
        35                  40                  45              


Pro Pro Pro Pro Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 
    50                  55                  60                  


Ala His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 
65                  70                  75                  80  


Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Thr Ala Glu 
                85                  90                  95      


Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met Asp Lys Leu 
            100                 105                 110         


Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
        115                 120                 125             


Gly Gln Arg Lys Glu Val Glu Val Phe Lys Ser Glu Asp Ala Leu Gly 
    130                 135                 140                 


Leu Thr Ile Thr Asp Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile 
145                 150                 155                 160 


Lys Glu Gly Ser Val Ile Asp His Ile His Leu Ile Ser Val Gly Asp 
                165                 170                 175     


Met Ile Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 
            180                 185                 190         


Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 
        195                 200                 205             


Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln Arg 
    210                 215                 220                 


Ser Ala Gly Gly Arg Pro Gly Ser Gly Pro Gln Leu Gly Thr Gly Arg 
225                 230                 235                 240 


Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Val Glu Asp Leu 
                245                 250                 255     


Pro Ser Ala Phe Glu Glu Lys Ala Ile Glu Lys Val Asp Asp Leu Leu 
            260                 265                 270         


Glu Ser Tyr Met Gly Ile Arg Asp Thr Glu Leu Ala Ala Thr Met Val 
        275                 280                 285             


Glu Leu Gly Lys Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 
    290                 295                 300                 


Asp Glu Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 
305                 310                 315                 320 


Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 
                325                 330             


<210>  4459
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIPC3__Homo_sapiens__NP_573568

<400>  4459

Met Glu Gly Ala Ala Ala Arg Glu Ala Arg Gly Thr Glu Thr Pro Arg 
1               5                   10                  15      


Ala Ser Ala Pro Pro Pro Ala Pro Ser Glu Pro Pro Ala Ala Pro Arg 
            20                  25                  30          


Ala Arg Pro Arg Leu Val Phe Arg Thr Gln Leu Ala His Gly Ser Pro 
        35                  40                  45              


Thr Gly Lys Ile Glu Gly Phe Thr Asn Val Arg Glu Leu Tyr Ala Lys 
    50                  55                  60                  


Ile Ala Glu Ala Phe Gly Ile Ala Pro Thr Glu Ile Leu Phe Cys Thr 
65                  70                  75                  80  


Leu Asn Ser His Lys Val Asp Met Gln Lys Leu Leu Gly Gly Gln Ile 
                85                  90                  95      


Gly Leu Glu Asp Phe Ile Phe Ala His Val Arg Gly Glu Thr Lys Glu 
            100                 105                 110         


Val Glu Val Thr Lys Thr Glu Asp Ala Leu Gly Leu Thr Ile Thr Asp 
        115                 120                 125             


Asn Gly Ala Gly Tyr Ala Phe Ile Lys Arg Ile Lys Glu Gly Ser Ile 
    130                 135                 140                 


Ile Asn Arg Ile Glu Ala Val Cys Val Gly Asp Ser Ile Glu Ala Ile 
145                 150                 155                 160 


Asn Asp His Ser Ile Val Gly Cys Arg His Tyr Glu Val Ala Lys Met 
                165                 170                 175     


Leu Arg Glu Leu Pro Lys Ser Gln Pro Phe Thr Leu Arg Leu Val Gln 
            180                 185                 190         


Pro Lys Arg Ala Phe Asp Met Ile Gly Gln Arg Ser Arg Ser Ser Lys 
        195                 200                 205             


Cys Pro Val Glu Ala Lys Val Thr Ser Gly Arg Glu Thr Leu Arg Leu 
    210                 215                 220                 


Arg Ser Gly Gly Ala Ala Thr Val Glu Glu Ala Pro Ser Glu Phe Glu 
225                 230                 235                 240 


Glu Glu Ala Ser Arg Lys Val Asp Asp Leu Leu Glu Ser Tyr Met Gly 
                245                 250                 255     


Ile Arg Asp Pro Glu Leu Ala Ser Thr Met Val Glu Thr Ser Lys Lys 
            260                 265                 270         


Thr Ala Ser Ala Gln Glu Phe Ala Arg Cys Leu Asp Ser Val Leu Gly 
        275                 280                 285             


Glu Phe Ala Phe Pro Asp Glu Phe Val Val Glu Val Trp Ala Ala Ile 
    290                 295                 300                 


Gly Glu Ala Arg Glu Ala Cys Gly 
305                 310         


<210>  4460
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIP__Homo_sapiens__NP_004114

<400>  4460

Met Val Ala Thr Lys Thr Phe Ala Leu Leu Leu Leu Ser Leu Phe Leu 
1               5                   10                  15      


Ala Val Gly Leu Gly Glu Lys Lys Glu Gly His Phe Ser Ala Leu Pro 
            20                  25                  30          


Ser Leu Pro Val Gly Ser His Ala Lys Val Ser Ser Pro Gln Pro Arg 
        35                  40                  45              


Gly Pro Arg Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala 
    50                  55                  60                  


Met Asp Lys Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
65                  70                  75                  80  


Lys Gly Lys Lys Asn Asp Trp Lys His Asn Ile Thr Gln Arg Glu Ala 
                85                  90                  95      


Arg Ala Leu Glu Leu Ala Ser Gln Ala Asn Arg Lys Glu Glu Glu Ala 
            100                 105                 110         


Val Glu Pro Gln Ser Ser Pro Ala Lys Asn Pro Ser Asp Glu Asp Leu 
        115                 120                 125             


Leu Arg Asp Leu Leu Ile Gln Glu Leu Leu Ala Cys Leu Leu Asp Gln 
    130                 135                 140                 


Thr Asn Leu Cys Arg Leu Arg Ser Arg 
145                 150             


<210>  4461
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIPR__Homo_sapiens__NP_000155

<400>  4461

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Phe Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser 
    450                 455                 460                 


Tyr Cys 
465     


<210>  4462
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIT1__Homo_sapiens__NP_001078923

<400>  4462

Met Ser Arg Lys Gly Pro Arg Ala Glu Val Cys Ala Asp Cys Ser Ala 
1               5                   10                  15      


Pro Asp Pro Gly Trp Ala Ser Ile Ser Arg Gly Val Leu Val Cys Asp 
            20                  25                  30          


Glu Cys Cys Ser Val His Arg Ser Leu Gly Arg His Ile Ser Ile Val 
        35                  40                  45              


Lys His Leu Arg His Ser Ala Trp Pro Pro Thr Leu Leu Gln Met Val 
    50                  55                  60                  


His Thr Leu Ala Ser Asn Gly Ala Asn Ser Ile Trp Glu His Ser Leu 
65                  70                  75                  80  


Leu Asp Pro Ala Gln Val Gln Ser Gly Arg Arg Lys Ala Asn Pro Gln 
                85                  90                  95      


Asp Lys Val His Pro Ile Lys Ser Glu Phe Ile Arg Ala Lys Tyr Gln 
            100                 105                 110         


Met Leu Ala Phe Val His Lys Leu Pro Cys Arg Asp Asp Asp Gly Val 
        115                 120                 125             


Thr Ala Lys Asp Leu Ser Lys Gln Leu His Ser Ser Val Arg Thr Gly 
    130                 135                 140                 


Asn Leu Glu Thr Cys Leu Arg Leu Leu Ser Leu Gly Ala Gln Ala Asn 
145                 150                 155                 160 


Phe Phe His Pro Glu Lys Gly Thr Thr Pro Leu His Val Ala Ala Lys 
                165                 170                 175     


Ala Gly Gln Thr Leu Gln Ala Glu Leu Leu Val Val Tyr Gly Ala Asp 
            180                 185                 190         


Pro Gly Ser Pro Asp Val Asn Gly Arg Thr Pro Ile Asp Tyr Ala Arg 
        195                 200                 205             


Gln Ala Gly His His Glu Leu Ala Glu Arg Leu Val Glu Cys Gln Tyr 
    210                 215                 220                 


Glu Leu Thr Asp Arg Leu Ala Phe Tyr Leu Cys Gly Arg Lys Pro Asp 
225                 230                 235                 240 


His Lys Asn Gly His Tyr Ile Ile Pro Gln Met Ala Asp Arg Ser Arg 
                245                 250                 255     


Gln Lys Cys Met Ser Gln Ser Leu Asp Leu Ser Glu Leu Ala Lys Ala 
            260                 265                 270         


Ala Lys Lys Lys Leu Gln Ala Leu Ser Asn Arg Leu Phe Glu Glu Leu 
        275                 280                 285             


Ala Met Asp Val Tyr Asp Glu Val Asp Arg Arg Glu Asn Asp Ala Val 
    290                 295                 300                 


Trp Leu Ala Thr Gln Asn His Ser Thr Leu Val Thr Glu Arg Ser Ala 
305                 310                 315                 320 


Val Pro Phe Leu Pro Val Asn Pro Glu Tyr Ser Ala Thr Arg Asn Gln 
                325                 330                 335     


Gly Arg Gln Lys Leu Ala Arg Phe Asn Ala Arg Glu Phe Ala Thr Leu 
            340                 345                 350         


Ile Ile Asp Ile Leu Ser Glu Ala Lys Arg Arg Gln Gln Gly Lys Ser 
        355                 360                 365             


Leu Ser Ser Pro Thr Asp Asn Leu Glu Leu Ser Leu Arg Ser Gln Ser 
    370                 375                 380                 


Asp Leu Asp Asp Gln His Asp Tyr Asp Ser Val Ala Ser Asp Glu Asp 
385                 390                 395                 400 


Thr Asp Gln Glu Pro Leu Arg Ser Thr Gly Ala Thr Arg Ser Asn Arg 
                405                 410                 415     


Ala Arg Ser Met Asp Ser Ser Asp Leu Ser Asp Gly Ala Val Thr Leu 
            420                 425                 430         


Gln Glu Tyr Leu Glu Leu Lys Lys Ala Leu Ala Thr Ser Glu Ala Lys 
        435                 440                 445             


Val Gln Gln Leu Met Lys Val Asn Ser Ser Leu Ser Asp Glu Leu Arg 
    450                 455                 460                 


Arg Leu Gln Arg Glu Ile His Lys Leu Gln Ala Glu Asn Leu Gln Leu 
465                 470                 475                 480 


Arg Gln Pro Pro Gly Pro Val Pro Thr Pro Pro Leu Pro Ser Glu Arg 
                485                 490                 495     


Ala Glu His Thr Pro Met Ala Pro Gly Gly Ser Thr His Arg Arg Asp 
            500                 505                 510         


Arg Gln Ala Phe Ser Met Tyr Glu Pro Gly Ser Ala Leu Lys Pro Phe 
        515                 520                 525             


Gly Gly Pro Pro Gly Asp Glu Leu Thr Thr Arg Leu Gln Pro Phe His 
    530                 535                 540                 


Ser Thr Glu Leu Glu Asp Asp Ala Ile Tyr Ser Val His Val Pro Ala 
545                 550                 555                 560 


Gly Leu Tyr Arg Ile Arg Lys Gly Val Ser Ala Ser Ala Val Pro Phe 
                565                 570                 575     


Thr Pro Ser Ser Pro Leu Leu Ser Cys Ser Gln Glu Gly Ser Arg His 
            580                 585                 590         


Thr Ser Lys Leu Ser Arg His Gly Ser Gly Ala Asp Ser Asp Tyr Glu 
        595                 600                 605             


Asn Thr Gln Ser Gly Asp Pro Leu Leu Gly Leu Glu Gly Lys Arg Phe 
    610                 615                 620                 


Leu Glu Leu Gly Lys Glu Glu Asp Phe His Pro Glu Leu Glu Ser Leu 
625                 630                 635                 640 


Asp Gly Asp Leu Asp Pro Gly Leu Pro Ser Thr Glu Asp Val Ile Leu 
                645                 650                 655     


Lys Thr Glu Gln Val Thr Lys Asn Ile Gln Glu Leu Leu Arg Ala Ala 
            660                 665                 670         


Gln Glu Phe Lys His Asp Ser Phe Val Pro Cys Ser Glu Lys Ile His 
        675                 680                 685             


Leu Ala Val Thr Glu Met Ala Ser Leu Phe Pro Lys Arg Pro Ala Leu 
    690                 695                 700                 


Glu Pro Val Arg Ser Ser Leu Arg Leu Leu Asn Ala Ser Ala Tyr Arg 
705                 710                 715                 720 


Leu Gln Ser Glu Cys Arg Lys Thr Val Pro Pro Glu Pro Gly Ala Pro 
                725                 730                 735     


Val Asp Phe Gln Leu Leu Thr Gln Gln Val Ile Gln Cys Ala Tyr Asp 
            740                 745                 750         


Ile Ala Lys Ala Ala Lys Gln Leu Val Thr Ile Thr Thr Arg Glu Lys 
        755                 760                 765             


Lys Gln 
    770 


<210>  4463
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIT2__Homo_sapiens__NP_001128685

<400>  4463

Met Ser Lys Arg Leu Arg Ser Ser Glu Val Cys Ala Asp Cys Ser Gly 
1               5                   10                  15      


Pro Asp Pro Ser Trp Ala Ser Val Asn Arg Gly Thr Phe Leu Cys Asp 
            20                  25                  30          


Glu Cys Cys Ser Val His Arg Ser Leu Gly Arg His Ile Ser Gln Val 
        35                  40                  45              


Arg His Leu Lys His Thr Pro Trp Pro Pro Thr Leu Leu Gln Met Val 
    50                  55                  60                  


Glu Thr Leu Tyr Asn Asn Gly Ala Asn Ser Ile Trp Glu His Ser Leu 
65                  70                  75                  80  


Leu Asp Pro Ala Ser Ile Met Ser Gly Arg Arg Lys Ala Asn Pro Gln 
                85                  90                  95      


Asp Lys Val His Pro Asn Lys Ala Glu Phe Ile Arg Ala Lys Tyr Gln 
            100                 105                 110         


Met Leu Ala Phe Val His Arg Leu Pro Cys Arg Asp Asp Asp Ser Val 
        115                 120                 125             


Thr Ala Lys Asp Leu Ser Lys Gln Leu His Ser Ser Val Arg Thr Gly 
    130                 135                 140                 


Asn Leu Glu Thr Cys Leu Arg Leu Leu Ser Leu Gly Ala Gln Ala Asn 
145                 150                 155                 160 


Phe Phe His Pro Glu Lys Gly Asn Thr Pro Leu His Val Ala Ser Lys 
                165                 170                 175     


Ala Gly Gln Ile Leu Gln Ala Glu Leu Leu Ala Val Tyr Gly Ala Asp 
            180                 185                 190         


Pro Gly Thr Gln Asp Ser Ser Gly Lys Thr Pro Val Asp Tyr Ala Arg 
        195                 200                 205             


Gln Gly Gly His His Glu Leu Ala Glu Arg Leu Val Glu Ile Gln Tyr 
    210                 215                 220                 


Glu Leu Thr Asp Arg Leu Ala Phe Tyr Leu Cys Gly Arg Lys Pro Asp 
225                 230                 235                 240 


His Lys Asn Gly Gln His Phe Ile Ile Pro Gln Met Ala Asp Arg Arg 
                245                 250                 255     


Leu Ser Leu Asp Leu Ser Glu Leu Ala Lys Ala Ala Lys Lys Lys Leu 
            260                 265                 270         


Gln Ser Leu Ser Asn His Leu Phe Glu Glu Leu Ala Met Asp Val Tyr 
        275                 280                 285             


Asp Glu Val Asp Arg Arg Glu Thr Asp Ala Val Trp Leu Ala Thr Gln 
    290                 295                 300                 


Asn His Ser Ala Leu Val Thr Glu Thr Thr Val Val Pro Phe Leu Pro 
305                 310                 315                 320 


Val Asn Pro Glu Tyr Ser Ser Thr Arg Asn Gln Gly Arg Gln Lys Leu 
                325                 330                 335     


Ala Arg Phe Asn Ala His Glu Phe Ala Thr Leu Val Ile Asp Ile Leu 
            340                 345                 350         


Ser Asp Ala Lys Arg Arg Gln Gln Gly Ser Ser Leu Ser Gly Ser Lys 
        355                 360                 365             


Asp Asn Val Glu Leu Ile Leu Lys Thr Ile Asn Asn Gln His Ser Val 
    370                 375                 380                 


Glu Ser Gln Asp Asn Asp Gln Pro Asp Tyr Asp Ser Val Ala Ser Asp 
385                 390                 395                 400 


Glu Asp Thr Asp Leu Glu Thr Thr Ala Ser Lys Thr Asn Arg Gln Lys 
                405                 410                 415     


Leu Gln Thr Leu Gln Ser Glu Asn Ser Asn Leu Arg Lys Gln Ala Thr 
            420                 425                 430         


Thr Asn Val Tyr Gln Val Gln Thr Gly Ser Glu Tyr Thr Asp Thr Ser 
        435                 440                 445             


Asn His Ser Ser Leu Lys Arg Arg Pro Ser Ala Arg Gly Ser Arg Pro 
    450                 455                 460                 


Met Ser Met Tyr Glu Thr Gly Ser Gly Gln Lys Pro Tyr Leu Pro Met 
465                 470                 475                 480 


Gly Glu Ala Ser Arg Pro Glu Glu Ser Arg Met Arg Leu Gln Pro Phe 
                485                 490                 495     


Pro Ala His Ala Ser Arg Leu Glu Lys Gln Asn Ser Thr Pro Glu Ser 
            500                 505                 510         


Asp Tyr Asp Asn Thr Pro Asn Asp Met Glu Pro Asp Gly Met Gly Ser 
        515                 520                 525             


Ser Arg Lys Gly Arg Gln Arg Ser Met Val Trp Pro Gly Asp Gly Leu 
    530                 535                 540                 


Val Pro Asp Thr Ala Glu Pro His Val Ala Pro Ser Pro Thr Leu Pro 
545                 550                 555                 560 


Ser Thr Glu Asp Val Ile Arg Lys Thr Glu Gln Ile Thr Lys Asn Ile 
                565                 570                 575     


Gln Glu Leu Leu Arg Ala Ala Gln Glu Asn Lys His Asp Ser Tyr Ile 
            580                 585                 590         


Pro Cys Ser Glu Arg Ile His Val Ala Val Thr Glu Met Ala Ala Leu 
        595                 600                 605             


Phe Pro Lys Lys Pro Lys Ser Asp Met Val Arg Thr Ser Leu Arg Leu 
    610                 615                 620                 


Leu Thr Ser Ser Ala Tyr Arg Leu Gln Ser Glu Cys Lys Lys Thr Leu 
625                 630                 635                 640 


Pro Gly Asp Pro Gly Ser Pro Thr Asp Val Gln Leu Val Thr Gln Gln 
                645                 650                 655     


Val Ile Gln Cys Ala Tyr Asp Ile Ala Lys Ala Ala Lys Gln Leu Val 
            660                 665                 670         


Thr Ile Thr Thr Lys Glu Asn Asn Asn 
        675                 680     


<210>  4464
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJA1__Homo_sapiens__NP_000156

<400>  4464

Met Gly Asp Trp Ser Ala Leu Gly Lys Leu Leu Asp Lys Val Gln Ala 
1               5                   10                  15      


Tyr Ser Thr Ala Gly Gly Lys Val Trp Leu Ser Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Leu Leu Gly Thr Ala Val Glu Ser Ala Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Ala Phe Arg Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Lys Ser Phe Pro Ile Ser His Val Arg Phe Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Val Pro Thr Leu Leu Tyr Leu Ala His Val 
                85                  90                  95      


Phe Tyr Val Met Arg Lys Glu Glu Lys Leu Asn Lys Lys Glu Glu Glu 
            100                 105                 110         


Leu Lys Val Ala Gln Thr Asp Gly Val Asn Val Asp Met His Leu Lys 
        115                 120                 125             


Gln Ile Glu Ile Lys Lys Phe Lys Tyr Gly Ile Glu Glu His Gly Lys 
    130                 135                 140                 


Val Lys Met Arg Gly Gly Leu Leu Arg Thr Tyr Ile Ile Ser Ile Leu 
145                 150                 155                 160 


Phe Lys Ser Ile Phe Glu Val Ala Phe Leu Leu Ile Gln Trp Tyr Ile 
                165                 170                 175     


Tyr Gly Phe Ser Leu Ser Ala Val Tyr Thr Cys Lys Arg Asp Pro Cys 
            180                 185                 190         


Pro His Gln Val Asp Cys Phe Leu Ser Arg Pro Thr Glu Lys Thr Ile 
        195                 200                 205             


Phe Ile Ile Phe Met Leu Val Val Ser Leu Val Ser Leu Ala Leu Asn 
    210                 215                 220                 


Ile Ile Glu Leu Phe Tyr Val Phe Phe Lys Gly Val Lys Asp Arg Val 
225                 230                 235                 240 


Lys Gly Lys Ser Asp Pro Tyr His Ala Thr Ser Gly Ala Leu Ser Pro 
                245                 250                 255     


Ala Lys Asp Cys Gly Ser Gln Lys Tyr Ala Tyr Phe Asn Gly Cys Ser 
            260                 265                 270         


Ser Pro Thr Ala Pro Leu Ser Pro Met Ser Pro Pro Gly Tyr Lys Leu 
        275                 280                 285             


Val Thr Gly Asp Arg Asn Asn Ser Ser Cys Arg Asn Tyr Asn Lys Gln 
    290                 295                 300                 


Ala Ser Glu Gln Asn Trp Ala Asn Tyr Ser Ala Glu Gln Asn Arg Met 
305                 310                 315                 320 


Gly Gln Ala Gly Ser Thr Ile Ser Asn Ser His Ala Gln Pro Phe Asp 
                325                 330                 335     


Phe Pro Asp Asp Asn Gln Asn Ser Lys Lys Leu Ala Ala Gly His Glu 
            340                 345                 350         


Leu Gln Pro Leu Ala Ile Val Asp Gln Arg Pro Ser Ser Arg Ala Ser 
        355                 360                 365             


Ser Arg Ala Ser Ser Arg Pro Arg Pro Asp Asp Leu Glu Ile 
    370                 375                 380         


<210>  4465
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJA3__Homo_sapiens__NP_068773

<400>  4465

Met Gly Asp Trp Ser Phe Leu Gly Arg Leu Leu Glu Asn Ala Gln Glu 
1               5                   10                  15      


His Ser Thr Val Ile Gly Lys Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Val Leu Gly Ala Ala Ala Glu Asp Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Thr Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Arg Ala Phe Pro Ile Ser His Ile Arg Phe Trp Ala Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Thr Leu Ile Tyr Leu Gly His Val 
                85                  90                  95      


Leu His Ile Val Arg Met Glu Glu Lys Lys Lys Glu Arg Glu Glu Glu 
            100                 105                 110         


Glu Gln Leu Lys Arg Glu Ser Pro Ser Pro Lys Glu Pro Pro Gln Asp 
        115                 120                 125             


Asn Pro Ser Ser Arg Asp Asp Arg Gly Arg Val Arg Met Ala Gly Ala 
    130                 135                 140                 


Leu Leu Arg Thr Tyr Val Phe Asn Ile Ile Phe Lys Thr Leu Phe Glu 
145                 150                 155                 160 


Val Gly Phe Ile Ala Gly Gln Tyr Phe Leu Tyr Gly Phe Glu Leu Lys 
                165                 170                 175     


Pro Leu Tyr Arg Cys Asp Arg Trp Pro Cys Pro Asn Thr Val Asp Cys 
            180                 185                 190         


Phe Ile Ser Arg Pro Thr Glu Lys Thr Ile Phe Ile Ile Phe Met Leu 
        195                 200                 205             


Ala Val Ala Cys Ala Ser Leu Leu Leu Asn Met Leu Glu Ile Tyr His 
    210                 215                 220                 


Leu Gly Trp Lys Lys Leu Lys Gln Gly Val Thr Ser Arg Leu Gly Pro 
225                 230                 235                 240 


Asp Ala Ser Glu Ala Pro Leu Gly Thr Ala Asp Pro Pro Pro Leu Pro 
                245                 250                 255     


Pro Ser Ser Arg Pro Pro Ala Val Ala Ile Gly Phe Pro Pro Tyr Tyr 
            260                 265                 270         


Ala His Thr Ala Ala Pro Leu Gly Gln Ala Arg Ala Val Gly Tyr Pro 
        275                 280                 285             


Gly Ala Pro Pro Pro Ala Ala Asp Phe Lys Leu Leu Ala Leu Thr Glu 
    290                 295                 300                 


Ala Arg Gly Lys Gly Gln Ser Ala Lys Leu Tyr Asn Gly His His His 
305                 310                 315                 320 


Leu Leu Met Thr Glu Gln Asn Trp Ala Asn Gln Ala Ala Glu Arg Gln 
                325                 330                 335     


Pro Pro Ala Leu Lys Ala Tyr Pro Ala Ala Ser Thr Pro Ala Ala Pro 
            340                 345                 350         


Ser Pro Val Gly Ser Ser Ser Pro Pro Leu Ala His Glu Ala Glu Ala 
        355                 360                 365             


Gly Ala Ala Pro Leu Leu Leu Asp Gly Ser Gly Ser Ser Leu Glu Gly 
    370                 375                 380                 


Ser Ala Leu Ala Gly Thr Pro Glu Glu Glu Glu Gln Ala Val Thr Thr 
385                 390                 395                 400 


Ala Ala Gln Met His Gln Pro Pro Leu Pro Leu Gly Asp Pro Gly Arg 
                405                 410                 415     


Ala Ser Lys Ala Ser Arg Ala Ser Ser Gly Arg Ala Arg Pro Glu Asp 
            420                 425                 430         


Leu Ala Ile 
        435 


<210>  4466
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJA8__Homo_sapiens__XP_011507719

<400>  4466

Met Gly Asp Trp Ser Phe Leu Gly Asn Ile Leu Glu Glu Val Asn Glu 
1               5                   10                  15      


His Ser Thr Val Ile Gly Arg Val Trp Leu Thr Val Leu Phe Ile Phe 
            20                  25                  30          


Arg Ile Leu Ile Leu Gly Thr Ala Ala Glu Phe Val Trp Gly Asp Glu 
        35                  40                  45              


Gln Ser Asp Phe Val Cys Asn Thr Gln Gln Pro Gly Cys Glu Asn Val 
    50                  55                  60                  


Cys Tyr Asp Glu Ala Phe Pro Ile Ser His Ile Arg Leu Trp Val Leu 
65                  70                  75                  80  


Gln Ile Ile Phe Val Ser Thr Pro Ser Leu Met Tyr Val Gly His Ala 
                85                  90                  95      


Val His Tyr Val Arg Met Glu Glu Lys Arg Lys Ser Arg Glu Ala Glu 
            100                 105                 110         


Glu Leu Gly Gln Gln Ala Gly Thr Asn Gly Gly Pro Asp Gln Gly Ser 
        115                 120                 125             


Val Lys Lys Ser Ser Gly Ser Lys Gly Thr Lys Lys Phe Arg Leu Glu 
    130                 135                 140                 


Gly Thr Leu Leu Arg Thr Tyr Ile Cys His Ile Ile Phe Lys Thr Leu 
145                 150                 155                 160 


Phe Glu Val Gly Phe Ile Val Gly His Tyr Phe Leu Tyr Gly Phe Arg 
                165                 170                 175     


Ile Leu Pro Leu Tyr Arg Cys Ser Arg Trp Pro Cys Pro Asn Val Val 
            180                 185                 190         


Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Ile Phe Ile Leu Phe 
        195                 200                 205             


Met Leu Ser Val Ala Ser Val Ser Leu Phe Leu Asn Val Met Glu Leu 
    210                 215                 220                 


Gly His Leu Gly Leu Lys Gly Ile Arg Ser Ala Leu Lys Arg Pro Val 
225                 230                 235                 240 


Glu Gln Pro Leu Gly Glu Ile Pro Glu Lys Ser Leu His Ser Ile Ala 
                245                 250                 255     


Val Ser Ser Ile Gln Lys Ala Lys Gly Tyr Gln Leu Leu Glu Glu Glu 
            260                 265                 270         


Lys Ile Val Ser His Tyr Phe Pro Leu Thr Glu Val Gly Met Val Glu 
        275                 280                 285             


Thr Ser Pro Leu Pro Ala Lys Pro Phe Asn Gln Phe Glu Glu Lys Ile 
    290                 295                 300                 


Ser Thr Gly Pro Leu Gly Asp Leu Ser Arg Gly Tyr Gln Glu Thr Leu 
305                 310                 315                 320 


Pro Ser Tyr Ala Gln Val Gly Ala Gln Glu Val Glu Gly Glu Gly Pro 
                325                 330                 335     


Pro Ala Glu Glu Gly Ala Glu Pro Glu Val Gly Glu Lys Lys Glu Glu 
            340                 345                 350         


Ala Glu Arg Leu Thr Thr Glu Glu Gln Glu Lys Val Ala Val Pro Glu 
        355                 360                 365             


Gly Glu Lys Val Glu Thr Pro Gly Val Asp Lys Glu Gly Glu Lys Glu 
    370                 375                 380                 


Glu Pro Gln Ser Glu Lys Val Ser Lys Gln Gly Leu Pro Ala Glu Lys 
385                 390                 395                 400 


Thr Pro Ser Leu Cys Pro Glu Leu Thr Thr Asp Asp Ala Arg Pro Leu 
                405                 410                 415     


Ser Arg Leu Ser Lys Ala Ser Ser Arg Ala Arg 
            420                 425         


<210>  4467
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJB1__Homo_sapiens__NP_000157

<400>  4467

Met Asn Trp Thr Gly Leu Tyr Thr Leu Leu Ser Gly Val Asn Arg His 
1               5                   10                  15      


Ser Thr Ala Ile Gly Arg Val Trp Leu Ser Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Val Leu Val Val Ala Ala Glu Ser Val Trp Gly Asp Glu Lys 
        35                  40                  45              


Ser Ser Phe Ile Cys Asn Thr Leu Gln Pro Gly Cys Asn Ser Val Cys 
    50                  55                  60                  


Tyr Asp Gln Phe Phe Pro Ile Ser His Val Arg Leu Trp Ser Leu Gln 
65                  70                  75                  80  


Leu Ile Leu Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


His Gln Gln His Ile Glu Lys Lys Met Leu Arg Leu Glu Gly His Gly 
            100                 105                 110         


Asp Pro Leu His Leu Glu Glu Val Lys Arg His Lys Val His Ile Ser 
        115                 120                 125             


Gly Thr Leu Trp Trp Thr Tyr Val Ile Ser Val Val Phe Arg Leu Leu 
    130                 135                 140                 


Phe Glu Ala Val Phe Met Tyr Val Phe Tyr Leu Leu Tyr Pro Gly Tyr 
145                 150                 155                 160 


Ala Met Val Arg Leu Val Lys Cys Asp Val Tyr Pro Cys Pro Asn Thr 
                165                 170                 175     


Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr Val 
            180                 185                 190         


Phe Met Leu Ala Ala Ser Gly Ile Cys Ile Ile Leu Asn Val Ala Glu 
        195                 200                 205             


Val Val Tyr Leu Ile Ile Arg Ala Cys Ala Arg Arg Ala Gln Arg Arg 
    210                 215                 220                 


Ser Asn Pro Pro Ser Arg Lys Gly Ser Gly Phe Gly His Arg Leu Ser 
225                 230                 235                 240 


Pro Glu Tyr Lys Gln Asn Glu Ile Asn Lys Leu Leu Ser Glu Gln Asp 
                245                 250                 255     


Gly Ser Leu Lys Asp Ile Leu Arg Arg Ser Pro Gly Thr Gly Ala Gly 
            260                 265                 270         


Leu Ala Glu Lys Ser Asp Arg Cys Ser Ala Cys 
        275                 280             


<210>  4468
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJB2__Homo_sapiens__NP_003995

<400>  4468

Met Asp Trp Gly Thr Leu Gln Thr Ile Leu Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Ile Leu Val Val Ala Ala Lys Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Ala Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Tyr Phe Pro Ile Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Arg Arg His Glu Lys Lys Arg Lys Phe Ile Lys Gly Glu Ile Lys 
            100                 105                 110         


Ser Glu Phe Lys Asp Ile Glu Glu Ile Lys Thr Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Val 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Val Met Tyr Asp Gly 
145                 150                 155                 160 


Phe Ser Met Gln Arg Leu Val Lys Cys Asn Ala Trp Pro Cys Pro Asn 
                165                 170                 175     


Thr Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Val Phe Met Ile Ala Val Ser Gly Ile Cys Ile Leu Leu Asn Val Thr 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Ile Arg Tyr Cys Ser Gly Lys Ser Lys Lys 
    210                 215                 220                 


Pro Val 
225     


<210>  4469
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJB6__Homo_sapiens__NP_001103691

<400>  4469

Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
            20                  25                  30          


Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
            100                 105                 110         


Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
145                 150                 155                 160 


Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
                165                 170                 175     


Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
    210                 215                 220                 


Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
225                 230                 235                 240 


Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
                245                 250                 255     


Thr Gly Phe Pro Ser 
            260     


<210>  4470
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJC1__Homo_sapiens__NP_001073852

<400>  4470

Met Ser Trp Ser Phe Leu Thr Arg Leu Leu Glu Glu Ile His Asn His 
1               5                   10                  15      


Ser Thr Phe Val Gly Lys Ile Trp Leu Thr Val Leu Ile Val Phe Arg 
            20                  25                  30          


Ile Val Leu Thr Ala Val Gly Gly Glu Ser Ile Tyr Tyr Asp Glu Gln 
        35                  40                  45              


Ser Lys Phe Val Cys Asn Thr Glu Gln Pro Gly Cys Glu Asn Val Cys 
    50                  55                  60                  


Tyr Asp Ala Phe Ala Pro Leu Ser His Val Arg Phe Trp Val Phe Gln 
65                  70                  75                  80  


Ile Ile Leu Val Ala Thr Pro Ser Val Met Tyr Leu Gly Tyr Ala Ile 
                85                  90                  95      


His Lys Ile Ala Lys Met Glu His Gly Glu Ala Asp Lys Lys Ala Ala 
            100                 105                 110         


Arg Ser Lys Pro Tyr Ala Met Arg Trp Lys Gln His Arg Ala Leu Glu 
        115                 120                 125             


Glu Thr Glu Glu Asp Asn Glu Glu Asp Pro Met Met Tyr Pro Glu Met 
    130                 135                 140                 


Glu Leu Glu Ser Asp Lys Glu Asn Lys Glu Gln Ser Gln Pro Lys Pro 
145                 150                 155                 160 


Lys His Asp Gly Arg Arg Arg Ile Arg Glu Asp Gly Leu Met Lys Ile 
                165                 170                 175     


Tyr Val Leu Gln Leu Leu Ala Arg Thr Val Phe Glu Val Gly Phe Leu 
            180                 185                 190         


Ile Gly Gln Tyr Phe Leu Tyr Gly Phe Gln Val His Pro Phe Tyr Val 
        195                 200                 205             


Cys Ser Arg Leu Pro Cys Pro His Lys Ile Asp Cys Phe Ile Ser Arg 
    210                 215                 220                 


Pro Thr Glu Lys Thr Ile Phe Leu Leu Ile Met Tyr Gly Val Thr Gly 
225                 230                 235                 240 


Leu Cys Leu Leu Leu Asn Ile Trp Glu Met Leu His Leu Gly Phe Gly 
                245                 250                 255     


Thr Ile Arg Asp Ser Leu Asn Ser Lys Arg Arg Glu Leu Glu Asp Pro 
            260                 265                 270         


Gly Ala Tyr Asn Tyr Pro Phe Thr Trp Asn Thr Pro Ser Ala Pro Pro 
        275                 280                 285             


Gly Tyr Asn Ile Ala Val Lys Pro Asp Gln Ile Gln Tyr Thr Glu Leu 
    290                 295                 300                 


Ser Asn Ala Lys Ile Ala Tyr Lys Gln Asn Lys Ala Asn Thr Ala Gln 
305                 310                 315                 320 


Glu Gln Gln Tyr Gly Ser His Glu Glu Asn Leu Pro Ala Asp Leu Glu 
                325                 330                 335     


Ala Leu Gln Arg Glu Ile Arg Met Ala Gln Glu Arg Leu Asp Leu Ala 
            340                 345                 350         


Val Gln Ala Tyr Ser His Gln Asn Asn Pro His Gly Pro Arg Glu Lys 
        355                 360                 365             


Lys Ala Lys Val Gly Ser Lys Ala Gly Ser Asn Lys Ser Thr Ala Ser 
    370                 375                 380                 


Ser Lys Ser Gly Asp Gly Lys Thr Ser Val Trp Ile 
385                 390                 395     


<210>  4471
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJC2__Homo_sapiens__NP_065168

<400>  4471

Met Thr Asn Met Ser Trp Ser Phe Leu Thr Arg Leu Leu Glu Glu Ile 
1               5                   10                  15      


His Asn His Ser Thr Phe Val Gly Lys Val Trp Leu Thr Val Leu Val 
            20                  25                  30          


Val Phe Arg Ile Val Leu Thr Ala Val Gly Gly Glu Ala Ile Tyr Ser 
        35                  40                  45              


Asp Glu Gln Ala Lys Phe Thr Cys Asn Thr Arg Gln Pro Gly Cys Asp 
    50                  55                  60                  


Asn Val Cys Tyr Asp Ala Phe Ala Pro Leu Ser His Val Arg Phe Trp 
65                  70                  75                  80  


Val Phe Gln Ile Val Val Ile Ser Thr Pro Ser Val Met Tyr Leu Gly 
                85                  90                  95      


Tyr Ala Val His Arg Leu Ala Arg Ala Ser Glu Gln Glu Arg Arg Arg 
            100                 105                 110         


Ala Leu Arg Arg Arg Pro Gly Pro Arg Arg Ala Pro Arg Ala His Leu 
        115                 120                 125             


Pro Pro Pro His Ala Gly Trp Pro Glu Pro Ala Asp Leu Gly Glu Glu 
    130                 135                 140                 


Glu Pro Met Leu Gly Leu Gly Glu Glu Glu Glu Glu Glu Glu Thr Gly 
145                 150                 155                 160 


Ala Ala Glu Gly Ala Gly Glu Glu Ala Glu Glu Ala Gly Ala Glu Glu 
                165                 170                 175     


Ala Cys Thr Lys Ala Val Gly Ala Asp Gly Lys Ala Ala Gly Thr Pro 
            180                 185                 190         


Gly Pro Thr Gly Gln His Asp Gly Arg Arg Arg Ile Gln Arg Glu Gly 
        195                 200                 205             


Leu Met Arg Val Tyr Val Ala Gln Leu Val Ala Arg Ala Ala Phe Glu 
    210                 215                 220                 


Val Ala Phe Leu Val Gly Gln Tyr Leu Leu Tyr Gly Phe Glu Val Arg 
225                 230                 235                 240 


Pro Phe Phe Pro Cys Ser Arg Gln Pro Cys Pro His Val Val Asp Cys 
                245                 250                 255     


Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Leu Leu Val Met Tyr 
            260                 265                 270         


Val Val Ser Cys Leu Cys Leu Leu Leu Asn Leu Cys Glu Met Ala His 
        275                 280                 285             


Leu Gly Leu Gly Ser Ala Gln Asp Ala Val Arg Gly Arg Arg Gly Pro 
    290                 295                 300                 


Pro Ala Ser Ala Pro Ala Pro Ala Pro Arg Pro Pro Pro Cys Ala Phe 
305                 310                 315                 320 


Pro Ala Ala Ala Ala Gly Leu Ala Cys Pro Pro Asp Tyr Ser Leu Val 
                325                 330                 335     


Val Arg Ala Ala Glu Arg Ala Arg Ala His Asp Gln Asn Leu Ala Asn 
            340                 345                 350         


Leu Ala Leu Gln Ala Leu Arg Asp Gly Ala Ala Ala Gly Asp Arg Asp 
        355                 360                 365             


Arg Asp Ser Ser Pro Cys Val Gly Leu Pro Ala Ala Ser Arg Gly Pro 
    370                 375                 380                 


Pro Arg Ala Gly Ala Pro Ala Ser Arg Thr Gly Ser Ala Thr Ser Ala 
385                 390                 395                 400 


Gly Thr Val Gly Glu Gln Gly Arg Pro Gly Thr His Glu Arg Pro Gly 
                405                 410                 415     


Ala Lys Pro Arg Ala Gly Ser Glu Lys Gly Ser Ala Ser Ser Arg Asp 
            420                 425                 430         


Gly Lys Thr Thr Val Trp Ile 
        435                 


<210>  4472
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJC3__Homo_sapiens__NP_853516

<400>  4472

Met Cys Gly Arg Phe Leu Arg Arg Leu Leu Ala Glu Glu Ser Arg Arg 
1               5                   10                  15      


Ser Thr Pro Val Gly Arg Leu Leu Leu Pro Val Leu Leu Gly Phe Arg 
            20                  25                  30          


Leu Val Leu Leu Ala Ala Ser Gly Pro Gly Val Tyr Gly Asp Glu Gln 
        35                  40                  45              


Ser Glu Phe Val Cys His Thr Gln Gln Pro Gly Cys Lys Ala Ala Cys 
    50                  55                  60                  


Phe Asp Ala Phe His Pro Leu Ser Pro Leu Arg Phe Trp Val Phe Gln 
65                  70                  75                  80  


Val Ile Leu Val Ala Val Pro Ser Ala Leu Tyr Met Gly Phe Thr Leu 
                85                  90                  95      


Tyr His Val Ile Trp His Trp Glu Leu Ser Gly Lys Gly Lys Glu Glu 
            100                 105                 110         


Glu Thr Leu Ile Gln Gly Arg Glu Gly Asn Thr Asp Val Pro Gly Ala 
        115                 120                 125             


Gly Ser Leu Arg Leu Leu Trp Ala Tyr Val Ala Gln Leu Gly Ala Arg 
    130                 135                 140                 


Leu Val Leu Glu Gly Ala Ala Leu Gly Leu Gln Tyr His Leu Tyr Gly 
145                 150                 155                 160 


Phe Gln Met Pro Ser Ser Phe Ala Cys Arg Arg Glu Pro Cys Leu Gly 
                165                 170                 175     


Ser Ile Thr Cys Asn Leu Ser Arg Pro Ser Glu Lys Thr Ile Phe Leu 
            180                 185                 190         


Lys Thr Met Phe Gly Val Ser Gly Phe Cys Leu Leu Phe Thr Phe Leu 
        195                 200                 205             


Glu Leu Val Leu Leu Gly Leu Gly Arg Trp Trp Arg Thr Trp Lys His 
    210                 215                 220                 


Lys Ser Ser Ser Ser Lys Tyr Phe Leu Thr Ser Glu Ser Thr Arg Arg 
225                 230                 235                 240 


His Lys Lys Ala Thr Asp Ser Leu Pro Val Val Glu Thr Lys Glu Gln 
                245                 250                 255     


Phe Gln Glu Ala Val Pro Gly Arg Ser Leu Ala Gln Glu Lys Gln Arg 
            260                 265                 270         


Pro Val Gly Pro Arg Asp Ala 
        275                 


<210>  4473
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJD2__Homo_sapiens__NP_065711

<400>  4473

Met Gly Glu Trp Thr Ile Leu Glu Arg Leu Leu Glu Ala Ala Val Gln 
1               5                   10                  15      


Gln His Ser Thr Met Ile Gly Arg Ile Leu Leu Thr Val Val Val Ile 
            20                  25                  30          


Phe Arg Ile Leu Ile Val Ala Ile Val Gly Glu Thr Val Tyr Asp Asp 
        35                  40                  45              


Glu Gln Thr Met Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Asn Gln 
    50                  55                  60                  


Ala Cys Tyr Asp Arg Ala Phe Pro Ile Ser His Ile Arg Tyr Trp Val 
65                  70                  75                  80  


Phe Gln Ile Ile Met Val Cys Thr Pro Ser Leu Cys Phe Ile Thr Tyr 
                85                  90                  95      


Ser Val His Gln Ser Ala Lys Gln Arg Glu Arg Arg Tyr Ser Thr Val 
            100                 105                 110         


Phe Leu Ala Leu Asp Arg Asp Pro Pro Glu Ser Ile Gly Gly Pro Gly 
        115                 120                 125             


Gly Thr Gly Gly Gly Gly Ser Gly Gly Gly Lys Arg Glu Asp Lys Lys 
    130                 135                 140                 


Leu Gln Asn Ala Ile Val Asn Gly Val Leu Gln Asn Thr Glu Asn Thr 
145                 150                 155                 160 


Ser Lys Glu Thr Glu Pro Asp Cys Leu Glu Val Lys Glu Leu Thr Pro 
                165                 170                 175     


His Pro Ser Gly Leu Arg Thr Ala Ser Lys Ser Lys Leu Arg Arg Gln 
            180                 185                 190         


Glu Gly Ile Ser Arg Phe Tyr Ile Ile Gln Val Val Phe Arg Asn Ala 
        195                 200                 205             


Leu Glu Ile Gly Phe Leu Val Gly Gln Tyr Phe Leu Tyr Gly Phe Ser 
    210                 215                 220                 


Val Pro Gly Leu Tyr Glu Cys Asn Arg Tyr Pro Cys Ile Lys Glu Val 
225                 230                 235                 240 


Glu Cys Tyr Val Ser Arg Pro Thr Glu Lys Thr Val Phe Leu Val Phe 
                245                 250                 255     


Met Phe Ala Val Ser Gly Ile Cys Val Val Leu Asn Leu Ala Glu Leu 
            260                 265                 270         


Asn His Leu Gly Trp Arg Lys Ile Lys Leu Ala Val Arg Gly Ala Gln 
        275                 280                 285             


Ala Lys Arg Lys Ser Ile Tyr Glu Ile Arg Asn Lys Asp Leu Pro Arg 
    290                 295                 300                 


Val Ser Val Pro Asn Phe Gly Arg Thr Gln Ser Ser Asp Ser Ala Tyr 
305                 310                 315                 320 


Val 
    


<210>  4474
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GJD3__Homo_sapiens__NP_689343

<400>  4474

Met Gly Glu Trp Ala Phe Leu Gly Ser Leu Leu Asp Ala Val Gln Leu 
1               5                   10                  15      


Gln Ser Pro Leu Val Gly Arg Leu Trp Leu Val Val Met Leu Ile Phe 
            20                  25                  30          


Arg Ile Leu Val Leu Ala Thr Val Gly Gly Ala Val Phe Glu Asp Glu 
        35                  40                  45              


Gln Glu Glu Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Arg Gln Thr 
    50                  55                  60                  


Cys Tyr Asp Arg Ala Phe Pro Val Ser His Tyr Arg Phe Trp Leu Phe 
65                  70                  75                  80  


His Ile Leu Leu Leu Ser Ala Pro Pro Val Leu Phe Val Val Tyr Ser 
                85                  90                  95      


Met His Arg Ala Gly Lys Glu Ala Gly Gly Ala Glu Ala Ala Ala Gln 
            100                 105                 110         


Cys Ala Pro Gly Leu Pro Glu Ala Gln Cys Ala Pro Cys Ala Leu Arg 
        115                 120                 125             


Ala Arg Arg Ala Arg Arg Cys Tyr Leu Leu Ser Val Ala Leu Arg Leu 
    130                 135                 140                 


Leu Ala Glu Leu Thr Phe Leu Gly Gly Gln Ala Leu Leu Tyr Gly Phe 
145                 150                 155                 160 


Arg Val Ala Pro His Phe Ala Cys Ala Gly Pro Pro Cys Pro His Thr 
                165                 170                 175     


Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Val Leu 
            180                 185                 190         


Phe Tyr Phe Ala Val Gly Leu Leu Ser Ala Leu Leu Ser Val Ala Glu 
        195                 200                 205             


Leu Gly His Leu Leu Trp Lys Gly Arg Pro Arg Ala Gly Glu Arg Asp 
    210                 215                 220                 


Asn Arg Cys Asn Arg Ala His Glu Glu Ala Gln Lys Leu Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Pro Pro Pro Pro Ala Leu Pro Ser Arg Arg Pro Gly 
                245                 250                 255     


Pro Glu Pro Cys Ala Pro Pro Ala Tyr Ala His Pro Ala Pro Ala Ser 
            260                 265                 270         


Leu Arg Glu Cys Gly Ser Gly Arg Gly Lys Ala Ser Pro Ala Thr Gly 
        275                 280                 285             


Arg Arg Asp Leu Ala Ile 
    290                 


<210>  4475
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GK__Homo_sapiens__NP_000158

<400>  4475

Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val 
1               5                   10                  15      


Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Lys Thr 
            20                  25                  30          


Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro 
        35                  40                  45              


Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val 
    50                  55                  60                  


Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile 
65                  70                  75                  80  


Asp Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr 
                85                  90                  95      


Thr Val Val Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val 
            100                 105                 110         


Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys 
        115                 120                 125             


Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro 
    130                 135                 140                 


Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn 
145                 150                 155                 160 


Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly 
                165                 170                 175     


Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly 
            180                 185                 190         


Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe 
        195                 200                 205             


Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly 
    210                 215                 220                 


Ile Pro Met Glu Ile Leu Pro Asn Val Arg Ser Ser Ser Glu Ile Tyr 
225                 230                 235                 240 


Gly Leu Met Lys Ala Gly Ala Leu Glu Gly Val Pro Ile Ser Gly Cys 
                245                 250                 255     


Leu Gly Asp Gln Ser Ala Ala Leu Val Gly Gln Met Cys Phe Gln Ile 
            260                 265                 270         


Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Cys Asn 
        275                 280                 285             


Thr Gly His Lys Cys Val Phe Ser Asp His Gly Leu Leu Thr Thr Val 
    290                 295                 300                 


Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val Tyr Tyr Ala Leu Glu Gly 
305                 310                 315                 320 


Ser Val Ala Ile Ala Gly Ala Val Ile Arg Trp Leu Arg Asp Asn Leu 
                325                 330                 335     


Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu Lys Leu Ala Lys Glu Val 
            340                 345                 350         


Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro Ala Phe Ser Gly Leu Tyr 
        355                 360                 365             


Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly Ile Ile Cys Gly Leu Thr 
    370                 375                 380                 


Gln Phe Thr Asn Lys Cys His Ile Ala Phe Ala Ala Leu Glu Ala Val 
385                 390                 395                 400 


Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala Met Asn Arg Asp Cys Gly 
                405                 410                 415     


Ile Pro Leu Ser His Leu Gln Val Asp Gly Gly Met Thr Ser Asn Lys 
            420                 425                 430         


Ile Leu Met Gln Leu Gln Ala Asp Ile Leu Tyr Ile Pro Val Val Lys 
        435                 440                 445             


Pro Ser Met Pro Glu Thr Thr Ala Leu Gly Ala Ala Met Ala Ala Gly 
    450                 455                 460                 


Ala Ala Glu Gly Val Gly Val Trp Ser Leu Glu Pro Glu Asp Leu Ser 
465                 470                 475                 480 


Ala Val Thr Met Glu Arg Phe Glu Pro Gln Ile Asn Ala Glu Glu Ser 
                485                 490                 495     


Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala Val Met Lys Ser Met Gly 
            500                 505                 510         


Trp Val Thr Thr Gln Ser Pro Glu Ser Gly Ile Pro 
        515                 520                 


<210>  4476
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GKN1__Homo_sapiens__NP_062563

<400>  4476

Met Leu Ala Tyr Ser Ser Val His Cys Phe Arg Glu Asp Lys Met Lys 
1               5                   10                  15      


Phe Thr Ile Val Phe Ala Gly Leu Leu Gly Val Phe Leu Ala Pro Ala 
            20                  25                  30          


Leu Ala Asn Tyr Asn Ile Asn Val Asn Asp Asp Asn Asn Asn Ala Gly 
        35                  40                  45              


Ser Gly Gln Gln Ser Val Ser Val Asn Asn Glu His Asn Val Ala Asn 
    50                  55                  60                  


Val Asp Asn Asn Asn Gly Trp Asp Ser Trp Asn Ser Ile Trp Asp Tyr 
65                  70                  75                  80  


Gly Asn Gly Phe Ala Ala Thr Arg Leu Phe Gln Lys Lys Thr Cys Ile 
                85                  90                  95      


Val His Lys Met Asn Lys Glu Val Met Pro Ser Ile Gln Ser Leu Asp 
            100                 105                 110         


Ala Leu Val Lys Glu Lys Lys Leu Gln Gly Lys Gly Pro Gly Gly Pro 
        115                 120                 125             


Pro Pro Lys Gly Leu Met Tyr Ser Val Asn Pro Asn Lys Val Asp Asp 
    130                 135                 140                 


Leu Ser Lys Phe Gly Lys Asn Ile Ala Asn Met Cys Arg Gly Ile Pro 
145                 150                 155                 160 


Thr Tyr Met Ala Glu Glu Met Gln Glu Ala Ser Leu Phe Phe Tyr Ser 
                165                 170                 175     


Gly Thr Cys Tyr Thr Thr Ser Val Leu Trp Ile Val Asp Ile Ser Phe 
            180                 185                 190         


Cys Gly Asp Thr Val Glu Asn 
        195                 


<210>  4477
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GKN2__Homo_sapiens__NP_872342

<400>  4477

Met Lys Ile Leu Val Ala Phe Leu Val Val Leu Thr Ile Phe Gly Ile 
1               5                   10                  15      


Gln Ser His Gly Tyr Glu Val Phe Asn Ile Ile Ser Pro Ser Asn Asn 
            20                  25                  30          


Gly Gly Asn Val Gln Glu Thr Val Thr Ile Asp Asn Glu Lys Asn Thr 
        35                  40                  45              


Ala Ile Ile Asn Ile His Ala Gly Ser Cys Ser Ser Thr Thr Ile Phe 
    50                  55                  60                  


Asp Tyr Lys His Gly Tyr Ile Ala Ser Arg Val Leu Ser Arg Arg Ala 
65                  70                  75                  80  


Cys Phe Ile Leu Lys Met Asp His Gln Asn Ile Pro Pro Leu Asn Asn 
                85                  90                  95      


Leu Gln Trp Tyr Ile Tyr Glu Lys Gln Ala Leu Asp Asn Met Phe Ser 
            100                 105                 110         


Ser Lys Tyr Thr Trp Val Lys Tyr Asn Pro Leu Glu Ser Leu Ile Lys 
        115                 120                 125             


Asp Val Asp Trp Phe Leu Leu Gly Ser Pro Ile Glu Lys Leu Cys Lys 
    130                 135                 140                 


His Ile Pro Leu Tyr Lys Gly Glu Val Val Glu Asn Thr His Asn Val 
145                 150                 155                 160 


Gly Ala Gly Gly Cys Ala Lys Ala Gly Leu Leu Gly Ile Leu Gly Ile 
                165                 170                 175     


Ser Ile Cys Ala Asp Ile His Val 
            180                 


<210>  4478
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLA__Homo_sapiens__NP_000160

<400>  4478

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  4479
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLB1__Homo_sapiens__NP_000395

<400>  4479

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Asn Ala Thr Gln Arg Met Phe 
            20                  25                  30          


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
        35                  40                  45              


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
    50                  55                  60                  


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
65                  70                  75                  80  


Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly Gln Tyr 
                85                  90                  95      


Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu Ala His 
            100                 105                 110         


Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala 
        115                 120                 125             


Glu Trp Glu Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Glu Ser 
    130                 135                 140                 


Ile Leu Leu Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val Asp Lys 
145                 150                 155                 160 


Trp Leu Gly Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln Asn 
                165                 170                 175     


Gly Gly Pro Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr 
            180                 185                 190         


Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe Arg 
        195                 200                 205             


His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala His 
    210                 215                 220                 


Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val 
225                 230                 235                 240 


Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg 
                245                 250                 255     


Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr Gly 
            260                 265                 270         


Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu Ala 
        275                 280                 285             


Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val Asn 
    290                 295                 300                 


Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly Ala 
305                 310                 315                 320 


Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala Pro 
                325                 330                 335     


Leu Ser Glu Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu Arg Asn 
            340                 345                 350         


Ile Ile Gln Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro Pro Ser 
        355                 360                 365             


Thr Pro Lys Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu Lys Thr 
    370                 375                 380                 


Val Gly Ala Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile Lys Ser 
385                 390                 395                 400 


Leu Tyr Pro Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly Phe Val 
                405                 410                 415     


Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala Pro Leu 
            420                 425                 430         


Ser Ser Pro Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala Val Asp 
        435                 440                 445             


Gly Ile Pro Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr Leu Asn 
    450                 455                 460                 


Ile Thr Gly Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu Asn Met 
465                 470                 475                 480 


Gly Arg Val Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly Leu Val 
                485                 490                 495     


Ser Asn Leu Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr Ile Phe 
            500                 505                 510         


Pro Leu Asp Thr Glu Asp Ala Val Arg Ser His Leu Gly Gly Trp Gly 
        515                 520                 525             


His Arg Asp Ser Gly His His Asp Glu Ala Trp Ala His Asn Ser Ser 
    530                 535                 540                 


Asn Tyr Thr Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp 
                565                 570                 575     


Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr Trp 
            580                 585                 590         


Pro Ala Arg Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His Ile Leu 
        595                 600                 605             


Met Thr Ser Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu Trp Ala 
    610                 615                 620                 


Pro Cys Ser Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe Val Asp 
625                 630                 635                 640 


Arg Pro Val Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser Lys Pro 
                645                 650                 655     


Val Glu Lys Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys Asp Ser 
            660                 665                 670         


Trp Leu Asp His Val 
        675         


<210>  4480
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLCCI1__Homo_sapiens__NP_612435

<400>  4480

Met Ser Thr Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Gln Thr Pro 
1               5                   10                  15      


His Pro Pro Ser Gln Arg Met Arg Arg Ser Ala Ala Gly Ser Pro Pro 
            20                  25                  30          


Ala Val Ala Ala Ala Gly Ser Gly Asn Gly Ala Gly Gly Gly Gly Gly 
        35                  40                  45              


Val Gly Cys Ala Pro Ala Ala Gly Ala Gly Arg Leu Leu Gln Pro Ile 
    50                  55                  60                  


Arg Ala Thr Val Pro Tyr Gln Leu Leu Arg Gly Ser Gln His Ser Pro 
65                  70                  75                  80  


Thr Arg Pro Pro Val Ala Ala Ala Ala Ala Ser Leu Gly Ser Leu Pro 
                85                  90                  95      


Gly Pro Gly Ala Ala Arg Gly Pro Ser Pro Ser Ser Pro Thr Pro Pro 
            100                 105                 110         


Ala Ala Ala Ala Pro Ala Glu Gln Ala Pro Arg Ala Lys Gly Arg Pro 
        115                 120                 125             


Arg Arg Ser Pro Glu Ser His Arg Arg Ser Ser Ser Pro Glu Arg Arg 
    130                 135                 140                 


Ser Pro Gly Ser Pro Val Cys Arg Ala Asp Lys Ala Lys Ser Gln Gln 
145                 150                 155                 160 


Val Arg Thr Ser Ser Thr Ile Arg Arg Thr Ser Ser Leu Asp Thr Ile 
                165                 170                 175     


Thr Gly Pro Tyr Leu Thr Gly Gln Trp Pro Arg Asp Pro His Val His 
            180                 185                 190         


Tyr Pro Ser Cys Met Lys Asp Lys Ala Thr Gln Thr Pro Ser Cys Trp 
        195                 200                 205             


Ala Glu Glu Gly Ala Glu Lys Arg Ser His Gln Arg Ser Ala Ser Trp 
    210                 215                 220                 


Gly Ser Ala Asp Gln Leu Lys Glu Gln Ile Ala Lys Leu Arg Gln Gln 
225                 230                 235                 240 


Leu Gln Arg Ser Lys Gln Ser Ser Arg His Ser Lys Glu Lys Asp Arg 
                245                 250                 255     


Gln Ser Pro Leu His Gly Asn His Ile Thr Ile Ser His Thr Gln Ala 
            260                 265                 270         


Thr Gly Ser Arg Ser Val Pro Met Pro Leu Ser Asn Ile Ser Val Pro 
        275                 280                 285             


Lys Ser Ser Val Ser Arg Val Pro Cys Asn Val Glu Gly Ile Ser Pro 
    290                 295                 300                 


Glu Leu Glu Lys Val Phe Ile Lys Glu Asn Asn Gly Lys Glu Glu Val 
305                 310                 315                 320 


Ser Lys Pro Leu Asp Ile Pro Asp Gly Arg Arg Ala Pro Leu Pro Ala 
                325                 330                 335     


His Tyr Arg Ser Ser Ser Thr Arg Ser Ile Asp Thr Gln Thr Pro Ser 
            340                 345                 350         


Val Gln Glu Arg Ser Ser Ser Cys Ser Ser His Ser Pro Cys Val Ser 
        355                 360                 365             


Pro Phe Cys Pro Pro Glu Ser Gln Asp Gly Ser Pro Cys Ser Thr Glu 
    370                 375                 380                 


Asp Leu Leu Tyr Asp Arg Asp Lys Asp Ser Gly Ser Ser Ser Pro Leu 
385                 390                 395                 400 


Pro Lys Tyr Ala Ser Ser Pro Lys Pro Asn Asn Ser Tyr Met Phe Lys 
                405                 410                 415     


Arg Glu Pro Pro Glu Gly Cys Glu Arg Val Lys Val Phe Glu Glu Met 
            420                 425                 430         


Ala Ser Arg Gln Pro Ile Ser Ala Pro Leu Phe Ser Cys Pro Asp Lys 
        435                 440                 445             


Asn Lys Val Asn Phe Ile Pro Thr Gly Ser Ala Phe Cys Pro Val Lys 
    450                 455                 460                 


Leu Leu Gly Pro Leu Leu Pro Ala Ser Asp Leu Met Leu Lys Asn Ser 
465                 470                 475                 480 


Pro Asn Ser Gly Gln Ser Ser Ala Leu Ala Thr Leu Thr Val Glu Gln 
                485                 490                 495     


Leu Ser Ser Arg Val Ser Phe Thr Ser Leu Ser Asp Asp Thr Ser Thr 
            500                 505                 510         


Ala Gly Ser Met Glu Ala Ser Val Gln Gln Pro Ser Gln Gln Gln Gln 
        515                 520                 525             


Leu Leu Gln Glu Leu Gln Gly Glu Asp His Ile Ser Ala Gln Asn Tyr 
    530                 535                 540                 


Val Ile Ile 
545         


<210>  4481
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLCE__Homo_sapiens__XP_005254355

<400>  4481

Met Arg Cys Leu Ala Ala Arg Val Asn Tyr Lys Thr Leu Ile Ile Ile 
1               5                   10                  15      


Cys Ala Leu Phe Thr Leu Val Thr Val Leu Leu Trp Asn Lys Cys Ser 
            20                  25                  30          


Ser Asp Lys Ala Ile Gln Phe Pro Arg Arg Ser Ser Ser Gly Phe Arg 
        35                  40                  45              


Val Asp Gly Phe Glu Lys Arg Ala Ala Ala Ser Glu Ser Asn Asn Tyr 
    50                  55                  60                  


Met Asn His Val Ala Lys Gln Gln Ser Glu Glu Ala Phe Pro Gln Glu 
65                  70                  75                  80  


Gln Gln Lys Ala Pro Pro Val Val Gly Gly Phe Asn Ser Asn Val Gly 
                85                  90                  95      


Ser Lys Val Leu Gly Leu Lys Tyr Glu Glu Ile Asp Cys Leu Ile Asn 
            100                 105                 110         


Asp Glu His Thr Ile Lys Gly Arg Arg Glu Gly Asn Glu Val Phe Leu 
        115                 120                 125             


Pro Phe Thr Trp Val Glu Lys Tyr Phe Asp Val Tyr Gly Lys Val Val 
    130                 135                 140                 


Gln Tyr Asp Gly Tyr Asp Arg Phe Glu Phe Ser His Ser Tyr Ser Lys 
145                 150                 155                 160 


Val Tyr Ala Gln Arg Ala Pro Tyr His Pro Asp Gly Val Phe Met Ser 
                165                 170                 175     


Phe Glu Gly Tyr Asn Val Glu Val Arg Asp Arg Val Lys Cys Ile Ser 
            180                 185                 190         


Gly Val Glu Gly Val Pro Leu Ser Thr Gln Trp Gly Pro Gln Gly Tyr 
        195                 200                 205             


Phe Tyr Pro Ile Gln Ile Ala Gln Tyr Gly Leu Ser His Tyr Ser Lys 
    210                 215                 220                 


Asn Leu Thr Glu Lys Pro Pro His Ile Glu Val Tyr Glu Thr Ala Glu 
225                 230                 235                 240 


Asp Arg Asp Lys Asn Lys Pro Asn Asp Trp Thr Val Pro Lys Gly Cys 
                245                 250                 255     


Phe Met Ala Asn Val Ala Asp Lys Ser Arg Phe Thr Asn Val Lys Gln 
            260                 265                 270         


Phe Ile Ala Pro Glu Thr Ser Glu Gly Val Ser Leu Gln Leu Gly Asn 
        275                 280                 285             


Thr Lys Asp Phe Ile Ile Ser Phe Asp Leu Lys Phe Leu Thr Asn Gly 
    290                 295                 300                 


Ser Val Ser Val Val Leu Glu Thr Thr Glu Lys Asn Gln Leu Phe Thr 
305                 310                 315                 320 


Ile His Tyr Val Ser Asn Ala Gln Leu Ile Ala Phe Lys Glu Arg Asp 
                325                 330                 335     


Ile Tyr Tyr Gly Ile Gly Pro Arg Thr Ser Trp Ser Thr Val Thr Arg 
            340                 345                 350         


Asp Leu Val Thr Asp Leu Arg Lys Gly Val Gly Leu Ser Asn Thr Lys 
        355                 360                 365             


Ala Val Lys Pro Thr Lys Ile Met Pro Lys Lys Val Val Arg Leu Ile 
    370                 375                 380                 


Ala Lys Gly Lys Gly Phe Leu Asp Asn Ile Thr Ile Ser Thr Thr Ala 
385                 390                 395                 400 


His Met Ala Ala Phe Phe Ala Ala Ser Asp Trp Leu Val Arg Asn Gln 
                405                 410                 415     


Asp Glu Lys Gly Gly Trp Pro Ile Met Val Thr Arg Lys Leu Gly Glu 
            420                 425                 430         


Gly Phe Lys Ser Leu Glu Pro Gly Trp Tyr Ser Ala Met Ala Gln Gly 
        435                 440                 445             


Gln Ala Ile Ser Thr Leu Val Arg Ala Tyr Leu Leu Thr Lys Asp His 
    450                 455                 460                 


Ile Phe Leu Asn Ser Ala Leu Arg Ala Thr Ala Pro Tyr Lys Phe Leu 
465                 470                 475                 480 


Ser Glu Gln His Gly Val Lys Ala Val Phe Met Asn Lys His Asp Trp 
                485                 490                 495     


Tyr Glu Glu Tyr Pro Thr Thr Pro Ser Ser Phe Val Leu Asn Gly Phe 
            500                 505                 510         


Met Tyr Ser Leu Ile Gly Leu Tyr Asp Leu Lys Glu Thr Ala Gly Glu 
        515                 520                 525             


Lys Leu Gly Lys Glu Ala Arg Ser Leu Tyr Glu Arg Gly Met Glu Ser 
    530                 535                 540                 


Leu Lys Ala Met Leu Pro Leu Tyr Asp Thr Gly Ser Gly Thr Ile Tyr 
545                 550                 555                 560 


Asp Leu Arg His Phe Met Leu Gly Ile Ala Pro Asn Leu Ala Arg Trp 
                565                 570                 575     


Asp Tyr His Thr Thr His Ile Asn Gln Leu Gln Leu Leu Ser Thr Ile 
            580                 585                 590         


Asp Glu Ser Pro Val Phe Lys Glu Phe Val Lys Arg Trp Lys Ser Tyr 
        595                 600                 605             


Leu Lys Gly Ser Arg Ala Lys His Asn 
    610                 615         


<210>  4482
<211>  1020
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLDC__Homo_sapiens__NP_000161

<400>  4482

Met Gln Ser Cys Ala Arg Ala Trp Gly Leu Arg Leu Gly Arg Gly Val 
1               5                   10                  15      


Gly Gly Gly Arg Arg Leu Ala Gly Gly Ser Gly Pro Cys Trp Ala Pro 
            20                  25                  30          


Arg Ser Arg Asp Ser Ser Ser Gly Gly Gly Asp Ser Ala Ala Ala Gly 
        35                  40                  45              


Ala Ser Arg Leu Leu Glu Arg Leu Leu Pro Arg His Asp Asp Phe Ala 
    50                  55                  60                  


Arg Arg His Ile Gly Pro Gly Asp Lys Asp Gln Arg Glu Met Leu Gln 
65                  70                  75                  80  


Thr Leu Gly Leu Ala Ser Ile Asp Glu Leu Ile Glu Lys Thr Val Pro 
                85                  90                  95      


Ala Asn Ile Arg Leu Lys Arg Pro Leu Lys Met Glu Asp Pro Val Cys 
            100                 105                 110         


Glu Asn Glu Ile Leu Ala Thr Leu His Ala Ile Ser Ser Lys Asn Gln 
        115                 120                 125             


Ile Trp Arg Ser Tyr Ile Gly Met Gly Tyr Tyr Asn Cys Ser Val Pro 
    130                 135                 140                 


Gln Thr Ile Leu Arg Asn Leu Leu Glu Asn Ser Gly Trp Ile Thr Gln 
145                 150                 155                 160 


Tyr Thr Pro Tyr Gln Pro Glu Val Ser Gln Gly Arg Leu Glu Ser Leu 
                165                 170                 175     


Leu Asn Tyr Gln Thr Met Val Cys Asp Ile Thr Gly Leu Asp Met Ala 
            180                 185                 190         


Asn Ala Ser Leu Leu Asp Glu Gly Thr Ala Ala Ala Glu Ala Leu Gln 
        195                 200                 205             


Leu Cys Tyr Arg His Asn Lys Arg Arg Lys Phe Leu Val Asp Pro Arg 
    210                 215                 220                 


Cys His Pro Gln Thr Ile Ala Val Val Gln Thr Arg Ala Lys Tyr Thr 
225                 230                 235                 240 


Gly Val Leu Thr Glu Leu Lys Leu Pro Cys Glu Met Asp Phe Ser Gly 
                245                 250                 255     


Lys Asp Val Ser Gly Val Leu Phe Gln Tyr Pro Asp Thr Glu Gly Lys 
            260                 265                 270         


Val Glu Asp Phe Thr Glu Leu Val Glu Arg Ala His Gln Ser Gly Ser 
        275                 280                 285             


Leu Ala Cys Cys Ala Thr Asp Leu Leu Ala Leu Cys Ile Leu Arg Pro 
    290                 295                 300                 


Pro Gly Glu Phe Gly Val Asp Ile Ala Leu Gly Ser Ser Gln Arg Phe 
305                 310                 315                 320 


Gly Val Pro Leu Gly Tyr Gly Gly Pro His Ala Ala Phe Phe Ala Val 
                325                 330                 335     


Arg Glu Ser Leu Val Arg Met Met Pro Gly Arg Met Val Gly Val Thr 
            340                 345                 350         


Arg Asp Ala Thr Gly Lys Glu Val Tyr Arg Leu Ala Leu Gln Thr Arg 
        355                 360                 365             


Glu Gln His Ile Arg Arg Asp Lys Ala Thr Ser Asn Ile Cys Thr Ala 
    370                 375                 380                 


Gln Ala Leu Leu Ala Asn Met Ala Ala Met Phe Ala Ile Tyr His Gly 
385                 390                 395                 400 


Ser His Gly Leu Glu His Ile Ala Arg Arg Val His Asn Ala Thr Leu 
                405                 410                 415     


Ile Leu Ser Glu Gly Leu Lys Arg Ala Gly His Gln Leu Gln His Asp 
            420                 425                 430         


Leu Phe Phe Asp Thr Leu Lys Ile Gln Cys Gly Cys Ser Val Lys Glu 
        435                 440                 445             


Val Leu Gly Arg Ala Ala Gln Arg Gln Ile Asn Phe Arg Leu Phe Glu 
    450                 455                 460                 


Asp Gly Thr Leu Gly Ile Ser Leu Asp Glu Thr Val Asn Glu Lys Asp 
465                 470                 475                 480 


Leu Asp Asp Leu Leu Trp Ile Phe Gly Cys Glu Ser Ser Ala Glu Leu 
                485                 490                 495     


Val Ala Glu Ser Met Gly Glu Glu Cys Arg Gly Ile Pro Gly Ser Val 
            500                 505                 510         


Phe Lys Arg Thr Ser Pro Phe Leu Thr His Gln Val Phe Asn Ser Tyr 
        515                 520                 525             


His Ser Glu Thr Asn Ile Val Arg Tyr Met Lys Lys Leu Glu Asn Lys 
    530                 535                 540                 


Asp Ile Ser Leu Val His Ser Met Ile Pro Leu Gly Ser Cys Thr Met 
545                 550                 555                 560 


Lys Leu Asn Ser Ser Ser Glu Leu Ala Pro Ile Thr Trp Lys Glu Phe 
                565                 570                 575     


Ala Asn Ile His Pro Phe Val Pro Leu Asp Gln Ala Gln Gly Tyr Gln 
            580                 585                 590         


Gln Leu Phe Arg Glu Leu Glu Lys Asp Leu Cys Glu Leu Thr Gly Tyr 
        595                 600                 605             


Asp Gln Val Cys Phe Gln Pro Asn Ser Gly Ala Gln Gly Glu Tyr Ala 
    610                 615                 620                 


Gly Leu Ala Thr Ile Arg Ala Tyr Leu Asn Gln Lys Gly Glu Gly His 
625                 630                 635                 640 


Arg Thr Val Cys Leu Ile Pro Lys Ser Ala His Gly Thr Asn Pro Ala 
                645                 650                 655     


Ser Ala His Met Ala Gly Met Lys Ile Gln Pro Val Glu Val Asp Lys 
            660                 665                 670         


Tyr Gly Asn Ile Asp Ala Val His Leu Lys Ala Met Val Asp Lys His 
        675                 680                 685             


Lys Glu Asn Leu Ala Ala Ile Met Ile Thr Tyr Pro Ser Thr Asn Gly 
    690                 695                 700                 


Val Phe Glu Glu Asn Ile Ser Asp Val Cys Asp Leu Ile His Gln His 
705                 710                 715                 720 


Gly Gly Gln Val Tyr Leu Asp Gly Ala Asn Met Asn Ala Gln Val Gly 
                725                 730                 735     


Ile Cys Arg Pro Gly Asp Phe Gly Ser Asp Val Ser His Leu Asn Leu 
            740                 745                 750         


His Lys Thr Phe Cys Ile Pro His Gly Gly Gly Gly Pro Gly Met Gly 
        755                 760                 765             


Pro Ile Gly Val Lys Lys His Leu Ala Pro Phe Leu Pro Asn His Pro 
    770                 775                 780                 


Val Ile Ser Leu Lys Arg Asn Glu Asp Ala Cys Pro Val Gly Thr Val 
785                 790                 795                 800 


Ser Ala Ala Pro Trp Gly Ser Ser Ser Ile Leu Pro Ile Ser Trp Ala 
                805                 810                 815     


Tyr Ile Lys Met Met Gly Gly Lys Gly Leu Lys Gln Ala Thr Glu Thr 
            820                 825                 830         


Ala Ile Leu Asn Ala Asn Tyr Met Ala Lys Arg Leu Glu Thr His Tyr 
        835                 840                 845             


Arg Ile Leu Phe Arg Gly Ala Arg Gly Tyr Val Gly His Glu Phe Ile 
    850                 855                 860                 


Leu Asp Thr Arg Pro Phe Lys Lys Ser Ala Asn Ile Glu Ala Val Asp 
865                 870                 875                 880 


Val Ala Lys Arg Leu Gln Asp Tyr Gly Phe His Ala Pro Thr Met Ser 
                885                 890                 895     


Trp Pro Val Ala Gly Thr Leu Met Val Glu Pro Thr Glu Ser Glu Asp 
            900                 905                 910         


Lys Ala Glu Leu Asp Arg Phe Cys Asp Ala Met Ile Ser Ile Arg Gln 
        915                 920                 925             


Glu Ile Ala Asp Ile Glu Glu Gly Arg Ile Asp Pro Arg Val Asn Pro 
    930                 935                 940                 


Leu Lys Met Ser Pro His Ser Leu Thr Cys Val Thr Ser Ser His Trp 
945                 950                 955                 960 


Asp Arg Pro Tyr Ser Arg Glu Val Ala Ala Phe Pro Leu Pro Phe Val 
                965                 970                 975     


Lys Pro Glu Asn Lys Phe Trp Pro Thr Ile Ala Arg Ile Asp Asp Ile 
            980                 985                 990         


Tyr Gly Asp Gln His Leu Val Cys  Thr Cys Pro Pro Met  Glu Val Tyr 
        995                 1000                 1005             


Glu Ser  Pro Phe Ser Glu Gln  Lys Arg Ala Ser Ser  
    1010                 1015                 1020 


<210>  4483
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLDN__Homo_sapiens__NP_861454

<400>  4483

Met Ala Arg Gly Ala Glu Gly Gly Arg Gly Asp Ala Gly Trp Gly Leu 
1               5                   10                  15      


Arg Gly Ala Leu Ala Ala Val Ala Leu Leu Ser Ala Leu Asn Ala Ala 
            20                  25                  30          


Gly Thr Val Phe Ala Leu Cys Gln Trp Arg Gly Leu Ser Ser Ala Leu 
        35                  40                  45              


Arg Ala Leu Glu Ala Gln Arg Gly Arg Glu Gln Arg Glu Asp Ser Ala 
    50                  55                  60                  


Leu Arg Ser Phe Leu Ala Glu Leu Ser Arg Ala Pro Arg Gly Ala Ser 
65                  70                  75                  80  


Ala Pro Pro Gln Asp Pro Ala Ser Ser Ala Arg Asn Lys Arg Ser His 
                85                  90                  95      


Ser Gly Glu Pro Ala Pro His Ile Arg Ala Glu Ser His Asp Met Leu 
            100                 105                 110         


Met Met Met Thr Tyr Ser Met Val Pro Ile Arg Val Met Val Asp Leu 
        115                 120                 125             


Cys Asn Ser Thr Lys Gly Ile Cys Leu Thr Gly Pro Ser Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Ala Gly Gly Leu Pro Gly His Asn Gly Leu Asp Gly 
145                 150                 155                 160 


Gln Pro Gly Pro Gln Gly Pro Lys Gly Glu Lys Gly Ala Asn Gly Lys 
                165                 170                 175     


Arg Gly Lys Met Gly Ile Pro Gly Ala Ala Gly Asn Pro Gly Glu Arg 
            180                 185                 190         


Gly Glu Lys Gly Asp His Gly Glu Leu Gly Leu Gln Gly Asn Glu Gly 
        195                 200                 205             


Pro Pro Gly Gln Lys Gly Glu Lys Gly Asp Lys Gly Asp Val Ser Asn 
    210                 215                 220                 


Asp Val Leu Leu Ala Gly Ala Lys Gly Asp Gln Gly Pro Pro Gly Pro 
225                 230                 235                 240 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ser Arg 
                245                 250                 255     


Arg Ala Lys Gly Pro Arg Gln Pro Ser Met Phe Asn Gly Gln Cys Pro 
            260                 265                 270         


Gly Glu Thr Cys Ala Ile Pro Asn Asp Asp Thr Leu Val Gly Lys Ala 
        275                 280                 285             


Asp Glu Lys Ala Ser Glu His His Ser Pro Gln Ala Glu Ser Met Ile 
    290                 295                 300                 


Thr Ser Ile Gly Asn Pro Val Gln Val Leu Lys Val Thr Glu Thr Phe 
305                 310                 315                 320 


Gly Thr Trp Ile Arg Glu Ser Ala Asn Lys Ser Asp Asp Arg Ile Trp 
                325                 330                 335     


Val Thr Glu His Phe Ser Gly Ile Met Val Lys Glu Phe Lys Asp Gln 
            340                 345                 350         


Pro Ser Leu Leu Asn Gly Ser Tyr Thr Phe Ile His Leu Pro Tyr Tyr 
        355                 360                 365             


Phe His Gly Cys Gly His Val Val Tyr Asn Asn Ser Leu Tyr Tyr His 
    370                 375                 380                 


Lys Gly Gly Ser Asn Thr Leu Val Arg Phe Glu Phe Gly Gln Glu Thr 
385                 390                 395                 400 


Ser Gln Thr Leu Lys Leu Glu Asn Ala Leu Tyr Phe Asp Arg Lys Tyr 
                405                 410                 415     


Leu Phe Ala Asn Ser Lys Thr Tyr Phe Asn Leu Ala Val Asp Glu Lys 
            420                 425                 430         


Gly Leu Trp Ile Ile Tyr Ala Ser Ser Val Asp Gly Ser Ser Ile Leu 
        435                 440                 445             


Val Ala Gln Leu Asp Glu Arg Thr Phe Ser Val Val Gln His Val Asn 
    450                 455                 460                 


Thr Thr Tyr Pro Lys Ser Lys Ala Gly Asn Ala Phe Ile Ala Arg Gly 
465                 470                 475                 480 


Ile Leu Tyr Val Thr Asp Thr Lys Asp Met Arg Val Thr Phe Ala Phe 
                485                 490                 495     


Asp Leu Leu Gly Gly Lys Gln Ile Asn Ala Asn Phe Asp Leu Arg Thr 
            500                 505                 510         


Ser Gln Ser Val Leu Ala Met Leu Ala Tyr Asn Met Arg Asp Gln His 
        515                 520                 525             


Leu Tyr Ser Trp Glu Asp Gly His Leu Met Leu Tyr Pro Val Gln Phe 
    530                 535                 540                 


Leu Ser Thr Thr Leu Asn Gln 
545                 550     


<210>  4484
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLE1__Homo_sapiens__NP_001003722

<400>  4484

Met Pro Ser Glu Gly Arg Cys Trp Glu Thr Leu Lys Ala Leu Arg Ser 
1               5                   10                  15      


Ser Asp Lys Gly Arg Leu Cys Tyr Tyr Arg Asp Trp Leu Leu Arg Arg 
            20                  25                  30          


Glu Asp Val Leu Glu Glu Cys Met Ser Leu Pro Lys Leu Ser Ser Tyr 
        35                  40                  45              


Ser Gly Trp Val Val Glu His Val Leu Pro His Met Gln Glu Asn Gln 
    50                  55                  60                  


Pro Leu Ser Glu Thr Ser Pro Ser Ser Thr Ser Ala Ser Ala Leu Asp 
65                  70                  75                  80  


Gln Pro Ser Phe Val Pro Lys Ser Pro Asp Ala Ser Ser Ala Phe Ser 
                85                  90                  95      


Pro Ala Ser Pro Ala Thr Pro Asn Gly Thr Lys Gly Lys Asp Glu Ser 
            100                 105                 110         


Gln His Thr Glu Ser Met Val Leu Gln Ser Ser Arg Gly Ile Lys Val 
        115                 120                 125             


Glu Gly Cys Val Arg Met Tyr Glu Leu Val His Arg Met Lys Gly Thr 
    130                 135                 140                 


Glu Gly Leu Arg Leu Trp Gln Glu Glu Gln Glu Arg Lys Val Gln Ala 
145                 150                 155                 160 


Leu Ser Glu Met Ala Ser Glu Gln Leu Lys Arg Phe Asp Glu Trp Lys 
                165                 170                 175     


Glu Leu Lys Gln His Lys Glu Phe Gln Asp Leu Arg Glu Val Met Glu 
            180                 185                 190         


Lys Ser Ser Arg Glu Ala Leu Gly His Gln Glu Lys Leu Lys Ala Glu 
        195                 200                 205             


His Arg His Arg Ala Lys Ile Leu Asn Leu Lys Leu Arg Glu Ala Glu 
    210                 215                 220                 


Gln Gln Arg Val Lys Gln Ala Glu Gln Glu Arg Leu Arg Lys Glu Glu 
225                 230                 235                 240 


Gly Gln Ile Arg Leu Arg Ala Leu Tyr Ala Leu Gln Glu Glu Met Leu 
                245                 250                 255     


Gln Leu Ser Gln Gln Leu Asp Ala Ser Glu Gln His Lys Ala Leu Leu 
            260                 265                 270         


Lys Val Asp Leu Ala Ala Phe Gln Thr Arg Gly Asn Gln Leu Cys Ser 
        275                 280                 285             


Leu Ile Ser Gly Ile Ile Arg Ala Ser Ser Glu Ser Ser Tyr Pro Thr 
    290                 295                 300                 


Ala Glu Ser Gln Ala Glu Ala Glu Arg Ala Leu Arg Glu Met Arg Asp 
305                 310                 315                 320 


Leu Leu Met Asn Leu Gly Gln Glu Ile Thr Arg Ala Cys Glu Asp Lys 
                325                 330                 335     


Arg Arg Gln Asp Glu Glu Glu Ala Gln Val Lys Leu Gln Glu Ala Gln 
            340                 345                 350         


Met Gln Gln Gly Pro Glu Ala His Lys Glu Pro Pro Ala Pro Ser Gln 
        355                 360                 365             


Gly Pro Gly Gly Lys Gln Asn Glu Asp Leu Gln Val Lys Val Gln Asp 
    370                 375                 380                 


Ile Thr Met Gln Trp Tyr Gln Gln Leu Gln Asp Ala Ser Met Gln Cys 
385                 390                 395                 400 


Val Leu Thr Phe Glu Gly Leu Thr Asn Ser Lys Asp Ser Gln Ala Lys 
                405                 410                 415     


Lys Ile Lys Met Asp Leu Gln Lys Ala Ala Thr Ile Pro Val Ser Gln 
            420                 425                 430         


Ile Ser Thr Ile Ala Gly Ser Lys Leu Lys Glu Ile Phe Asp Lys Ile 
        435                 440                 445             


His Ser Leu Leu Ser Gly Lys Pro Val Gln Ser Gly Gly Arg Ser Val 
    450                 455                 460                 


Ser Val Thr Leu Asn Pro Gln Gly Leu Asp Phe Val Gln Tyr Lys Leu 
465                 470                 475                 480 


Ala Glu Lys Phe Val Lys Gln Gly Glu Glu Glu Val Ala Ser His His 
                485                 490                 495     


Glu Ala Ala Phe Pro Ile Ala Val Val Ala Ser Gly Ile Trp Glu Leu 
            500                 505                 510         


His Pro Arg Val Gly Asp Leu Ile Leu Ala His Leu His Lys Lys Cys 
        515                 520                 525             


Pro Tyr Ser Val Pro Phe Tyr Pro Thr Phe Lys Glu Gly Met Ala Leu 
    530                 535                 540                 


Glu Asp Tyr Gln Arg Met Leu Gly Tyr Gln Val Lys Asp Ser Lys Val 
545                 550                 555                 560 


Glu Gln Gln Asp Asn Phe Leu Lys Arg Met Ser Gly Met Ile Arg Leu 
                565                 570                 575     


Tyr Ala Ala Ile Ile Gln Leu Arg Trp Pro Tyr Gly Asn Arg Gln Glu 
            580                 585                 590         


Ile His Pro His Gly Leu Asn His Gly Trp Arg Trp Leu Ala Gln Ile 
        595                 600                 605             


Leu Asn Met Glu Pro Leu Ser Asp Val Thr Ala Thr Leu Leu Phe Asp 
    610                 615                 620                 


Phe Leu Glu Val Cys Gly Asn Ala Leu Met Lys Gln Tyr Gln Val Gln 
625                 630                 635                 640 


Phe Trp Lys Met Leu Ile Leu Ile Lys Glu Asp Tyr Phe Pro Arg Ile 
                645                 650                 655     


Glu Ala Ile Thr Ser Ser Gly Gln Met Gly Ser Phe Ile Arg Leu Lys 
            660                 665                 670         


Gln Phe Leu Glu Lys Cys Leu Gln His Lys Asp Ile Pro Val Pro Lys 
        675                 680                 685             


Gly Phe Leu Thr Ser Ser Phe Trp Arg Ser 
    690                 695             


<210>  4485
<211>  1192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLG1__Homo_sapiens__NP_001139138

<400>  4485

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Leu Leu Trp Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys 
145                 150                 155                 160 


Phe Glu Ser Val Ala Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile 
                165                 170                 175     


Lys Glu Cys Ala Asp Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys 
            180                 185                 190         


Leu Val Asp His Arg Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr 
        195                 200                 205             


Ile Thr Lys Met Thr Ala Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys 
    210                 215                 220                 


Gly Phe Met Asp Asp Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly 
225                 230                 235                 240 


Ser Ile Arg Leu Gly Glu Lys Asp Ala His Ser Gln Gly Glu Val Val 
                245                 250                 255     


Ser Cys Leu Glu Lys Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro 
            260                 265                 270         


Lys Ile Gln Val Ser Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala 
        275                 280                 285             


Glu Leu Ser Ser Asp Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala 
    290                 295                 300                 


Cys Arg Asp Asp Arg Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu 
305                 310                 315                 320 


Gly Arg Val Tyr Lys Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met 
                325                 330                 335     


Ser Glu Lys Cys Arg Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala 
            340                 345                 350         


Gln Asp Tyr Lys Val Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp 
        355                 360                 365             


Leu Lys Lys Tyr Arg Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu 
    370                 375                 380                 


Ala Arg Leu Ser Tyr Leu Leu Met Cys Leu Glu Ser Ala Val His Arg 
385                 390                 395                 400 


Gly Arg Gln Val Ser Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg 
                405                 410                 415     


Arg Met Leu Met Glu Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser 
            420                 425                 430         


Cys Arg Gly Glu Ile Glu His His Cys Ser Gly Leu His Arg Lys Gly 
        435                 440                 445             


Arg Thr Leu His Cys Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn 
    450                 455                 460                 


Leu Gly Met Asn Cys Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr 
465                 470                 475                 480 


Asp Pro Gly Ala Asp Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys 
                485                 490                 495     


Glu Ser Val Ile Gln Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro 
            500                 505                 510         


Met Ile Leu Ser Cys Leu Met Glu His Leu Tyr Thr Glu Lys Met Val 
        515                 520                 525             


Glu Asp Cys Glu His Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg 
    530                 535                 540                 


Asp Trp Lys Leu Asp Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala 
545                 550                 555                 560 


Ser Arg Leu Cys His Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met 
                565                 570                 575     


Pro Gln Gly Ala Val Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr 
            580                 585                 590         


Glu Glu Gln Gly Arg Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln 
        595                 600                 605             


Arg Ile Leu His Gln Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu 
    610                 615                 620                 


Gln Asp Lys Cys Leu Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr 
625                 630                 635                 640 


Glu Thr Gly Gln Glu Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu 
                645                 650                 655     


Val Val Glu Cys Arg Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser 
            660                 665                 670         


Glu Asp Ile Gln Ile Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile 
        675                 680                 685             


Ile Gln Asn Phe Cys His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly 
    690                 695                 700                 


Asp Leu Met Glu Cys Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn 
705                 710                 715                 720 


Glu Lys Cys Ala Ile Gly Val Thr His Phe Gln Leu Val Gln Met Lys 
                725                 730                 735     


Asp Phe Arg Phe Ser Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val 
            740                 745                 750         


Leu Lys Leu Cys Pro Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys 
        755                 760                 765             


Leu Ser Thr Thr Val Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His 
    770                 775                 780                 


Arg Val Ser Leu Lys Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu 
785                 790                 795                 800 


Met Thr Glu Asp Ile Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys 
                805                 810                 815     


Ser Asp Ile Lys Asn Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln 
            820                 825                 830         


Ile Ile Glu Cys Leu Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys 
        835                 840                 845             


His Gln Lys Val Phe Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu 
    850                 855                 860                 


Leu Asp Tyr Thr Leu Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe 
865                 870                 875                 880 


Cys Pro Glu Ala Asp Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn 
                885                 890                 895     


Lys Asn Ser Glu Leu Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys 
            900                 905                 910         


Arg Gln Ile Thr Gln Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg 
        915                 920                 925             


Lys Ala Cys Lys Ala Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr 
    930                 935                 940                 


Lys Ala Lys Asp Asp Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu 
945                 950                 955                 960 


Lys Leu Arg Tyr Ala Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln 
                965                 970                 975     


Ile Arg Ile Ile Ile Gln Glu Ser Ala Leu Asp Tyr Arg Leu Asp Pro 
            980                 985                 990         


Gln Leu Gln Leu His Cys Ser Asp  Glu Ile Ser Ser Leu  Cys Ala Glu 
        995                 1000                 1005             


Glu Ala  Ala Ala Gln Glu Gln  Thr Gly Gln Val Glu  Glu Cys Leu 
    1010                 1015                 1020             


Lys Val  Asn Leu Leu Lys Ile  Lys Thr Glu Leu Cys  Lys Lys Glu 
    1025                 1030                 1035             


Val Leu  Asn Met Leu Lys Glu  Ser Lys Ala Asp Ile  Phe Val Asp 
    1040                 1045                 1050             


Pro Val  Leu His Thr Ala Cys  Ala Leu Asp Ile Lys  His His Cys 
    1055                 1060                 1065             


Ala Ala  Ile Thr Pro Gly Arg  Gly Arg Gln Met Ser  Cys Leu Met 
    1070                 1075                 1080             


Glu Ala  Leu Glu Asp Lys Arg  Val Arg Leu Gln Pro  Glu Cys Lys 
    1085                 1090                 1095             


Lys Arg  Leu Asn Asp Arg Ile  Glu Met Trp Ser Tyr  Ala Ala Lys 
    1100                 1105                 1110             


Val Ala  Pro Ala Asp Gly Phe  Ser Asp Leu Ala Met  Gln Val Met 
    1115                 1120                 1125             


Thr Ser  Pro Ser Lys Asn Tyr  Ile Leu Ser Val Ile  Ser Gly Ser 
    1130                 1135                 1140             


Ile Cys  Ile Leu Phe Leu Ile  Gly Leu Met Cys Gly  Arg Ile Thr 
    1145                 1150                 1155             


Lys Arg  Val Thr Arg Glu Leu  Lys Asp Arg Leu Gln  Tyr Arg Ser 
    1160                 1165                 1170             


Glu Thr  Met Ala Tyr Lys Gly  Leu Val Trp Ser Gln  Asp Val Thr 
    1175                 1180                 1185             


Gly Ser  Pro Ala 
    1190         


<210>  4486
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLI1__Homo_sapiens__NP_001161081

<400>  4486

Met Phe Asn Ser Met Thr Pro Pro Pro Ile Ser Ser Tyr Gly Glu Pro 
1               5                   10                  15      


Cys Cys Leu Arg Pro Leu Pro Ser Gln Gly Ala Pro Ser Val Gly Thr 
            20                  25                  30          


Glu Val Lys Leu Thr Lys Lys Arg Ala Leu Ser Ile Ser Pro Leu Ser 
        35                  40                  45              


Asp Ala Ser Leu Asp Leu Gln Thr Val Ile Arg Thr Ser Pro Ser Ser 
    50                  55                  60                  


Leu Val Ala Phe Ile Asn Ser Arg Cys Thr Ser Pro Gly Gly Ser Tyr 
65                  70                  75                  80  


Gly His Leu Ser Ile Gly Thr Met Ser Pro Ser Leu Gly Phe Pro Ala 
                85                  90                  95      


Gln Met Asn His Gln Lys Gly Pro Ser Pro Ser Phe Gly Val Gln Pro 
            100                 105                 110         


Cys Gly Pro His Asp Ser Ala Arg Gly Gly Met Ile Pro His Pro Gln 
        115                 120                 125             


Ser Arg Gly Pro Phe Pro Thr Cys Gln Leu Lys Ser Glu Leu Asp Met 
    130                 135                 140                 


Leu Val Gly Lys Cys Arg Glu Glu Pro Leu Glu Gly Asp Met Ser Ser 
145                 150                 155                 160 


Pro Asn Ser Thr Gly Ile Gln Asp Pro Leu Leu Gly Met Leu Asp Gly 
                165                 170                 175     


Arg Glu Asp Leu Glu Arg Glu Glu Lys Arg Glu Pro Glu Ser Val Tyr 
            180                 185                 190         


Glu Thr Asp Cys Arg Trp Asp Gly Cys Ser Gln Glu Phe Asp Ser Gln 
        195                 200                 205             


Glu Gln Leu Val His His Ile Asn Ser Glu His Ile His Gly Glu Arg 
    210                 215                 220                 


Lys Glu Phe Val Cys His Trp Gly Gly Cys Ser Arg Glu Leu Arg Pro 
225                 230                 235                 240 


Phe Lys Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly 
                245                 250                 255     


Glu Lys Pro His Lys Cys Thr Phe Glu Gly Cys Arg Lys Ser Tyr Ser 
            260                 265                 270         


Arg Leu Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Met Cys Glu His Glu Gly Cys Ser Lys Ala Phe Ser Asn Ala 
    290                 295                 300                 


Ser Asp Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro 
305                 310                 315                 320 


Tyr Val Cys Lys Leu Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser 
                325                 330                 335     


Ser Leu Arg Lys His Val Lys Thr Val His Gly Pro Asp Ala His Val 
            340                 345                 350         


Thr Lys Arg His Arg Gly Asp Gly Pro Leu Pro Arg Ala Pro Ser Ile 
        355                 360                 365             


Ser Thr Val Glu Pro Lys Arg Glu Arg Glu Gly Gly Pro Ile Arg Glu 
    370                 375                 380                 


Glu Ser Arg Leu Thr Val Pro Glu Gly Ala Met Lys Pro Gln Pro Ser 
385                 390                 395                 400 


Pro Gly Ala Gln Ser Ser Cys Ser Ser Asp His Ser Pro Ala Gly Ser 
                405                 410                 415     


Ala Ala Asn Thr Asp Ser Gly Val Glu Met Thr Gly Asn Ala Gly Gly 
            420                 425                 430         


Ser Thr Glu Asp Leu Ser Ser Leu Asp Glu Gly Pro Cys Ile Ala Gly 
        435                 440                 445             


Thr Gly Leu Ser Thr Leu Arg Arg Leu Glu Asn Leu Arg Leu Asp Gln 
    450                 455                 460                 


Leu His Gln Leu Arg Pro Ile Gly Thr Arg Gly Leu Lys Leu Pro Ser 
465                 470                 475                 480 


Leu Ser His Thr Gly Thr Thr Val Ser Arg Arg Val Gly Pro Pro Val 
                485                 490                 495     


Ser Leu Glu Arg Arg Ser Ser Ser Ser Ser Ser Ile Ser Ser Ala Tyr 
            500                 505                 510         


Thr Val Ser Arg Arg Ser Ser Leu Ala Ser Pro Phe Pro Pro Gly Ser 
        515                 520                 525             


Pro Pro Glu Asn Gly Ala Ser Ser Leu Pro Gly Leu Met Pro Ala Gln 
    530                 535                 540                 


His Tyr Leu Leu Arg Ala Arg Tyr Ala Ser Ala Arg Gly Gly Gly Thr 
545                 550                 555                 560 


Ser Pro Thr Ala Ala Ser Ser Leu Asp Arg Ile Gly Gly Leu Pro Met 
                565                 570                 575     


Pro Pro Trp Arg Ser Arg Ala Glu Tyr Pro Gly Tyr Asn Pro Asn Ala 
            580                 585                 590         


Gly Val Thr Arg Arg Ala Ser Asp Pro Ala Gln Ala Ala Asp Arg Pro 
        595                 600                 605             


Ala Pro Ala Arg Val Gln Arg Phe Lys Ser Leu Gly Cys Val His Thr 
    610                 615                 620                 


Pro Pro Thr Val Ala Gly Gly Gly Gln Asn Phe Asp Pro Tyr Leu Pro 
625                 630                 635                 640 


Thr Ser Val Tyr Ser Pro Gln Pro Pro Ser Ile Thr Glu Asn Ala Ala 
                645                 650                 655     


Met Asp Ala Arg Gly Leu Gln Glu Glu Pro Glu Val Gly Thr Ser Met 
            660                 665                 670         


Val Gly Ser Gly Leu Asn Pro Tyr Met Asp Phe Pro Pro Thr Asp Thr 
        675                 680                 685             


Leu Gly Tyr Gly Gly Pro Glu Gly Ala Ala Ala Glu Pro Tyr Gly Ala 
    690                 695                 700                 


Arg Gly Pro Gly Ser Leu Pro Leu Gly Pro Gly Pro Pro Thr Asn Tyr 
705                 710                 715                 720 


Gly Pro Asn Pro Cys Pro Gln Gln Ala Ser Tyr Pro Asp Pro Thr Gln 
                725                 730                 735     


Glu Thr Trp Gly Glu Phe Pro Ser His Ser Gly Leu Tyr Pro Gly Pro 
            740                 745                 750         


Lys Ala Leu Gly Gly Thr Tyr Ser Gln Cys Pro Arg Leu Glu His Tyr 
        755                 760                 765             


Gly Gln Val Gln Val Lys Pro Glu Gln Gly Cys Pro Val Gly Ser Asp 
    770                 775                 780                 


Ser Thr Gly Leu Ala Pro Cys Leu Asn Ala His Pro Ser Glu Gly Pro 
785                 790                 795                 800 


Pro His Pro Gln Pro Leu Phe Ser His Tyr Pro Gln Pro Ser Pro Pro 
                805                 810                 815     


Gln Tyr Leu Gln Ser Gly Pro Tyr Thr Gln Pro Pro Pro Asp Tyr Leu 
            820                 825                 830         


Pro Ser Glu Pro Arg Pro Cys Leu Asp Phe Asp Ser Pro Thr His Ser 
        835                 840                 845             


Thr Gly Gln Leu Lys Ala Gln Leu Val Cys Asn Tyr Val Gln Ser Gln 
    850                 855                 860                 


Gln Glu Leu Leu Trp Glu Gly Gly Gly Arg Glu Asp Ala Pro Ala Gln 
865                 870                 875                 880 


Glu Pro Ser Tyr Gln Ser Pro Lys Phe Leu Gly Gly Ser Gln Val Ser 
                885                 890                 895     


Pro Ser Arg Ala Lys Ala Pro Val Asn Thr Tyr Gly Pro Gly Phe Gly 
            900                 905                 910         


Pro Asn Leu Pro Asn His Lys Ser Gly Ser Tyr Pro Thr Pro Ser Pro 
        915                 920                 925             


Cys His Glu Asn Phe Val Val Gly Ala Asn Arg Ala Ser His Arg Ala 
    930                 935                 940                 


Ala Ala Pro Pro Arg Leu Leu Pro Pro Leu Pro Thr Cys Tyr Gly Pro 
945                 950                 955                 960 


Leu Lys Val Gly Gly Thr Asn Pro Ser Cys Gly His Pro Glu Val Gly 
                965                 970                 975     


Arg Leu Gly Gly Gly Pro Ala Leu Tyr Pro Pro Pro Glu Gly Gln Val 
            980                 985                 990         


Cys Asn Pro Leu Asp Ser Leu Asp  Leu Asp Asn Thr Gln  Leu Asp Phe 
        995                 1000                 1005             


Val Ala  Ile Leu Asp Glu Pro  Gln Gly Leu Ser Pro  Pro Pro Ser 
    1010                 1015                 1020             


His Asp  Gln Arg Gly Ser Ser  Gly His Thr Pro Pro  Pro Ser Gly 
    1025                 1030                 1035             


Pro Pro  Asn Met Ala Val Gly  Asn Met Ser Val Leu  Leu Arg Ser 
    1040                 1045                 1050             


Leu Pro  Gly Glu Thr Glu Phe  Leu Asn Ser Ser Ala  
    1055                 1060                 1065 


<210>  4487
<211>  1586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLI2__Homo_sapiens__NP_005261

<400>  4487

Met Glu Thr Ser Ala Ser Ala Thr Ala Ser Glu Lys Gln Glu Ala Lys 
1               5                   10                  15      


Ser Gly Ile Leu Glu Ala Ala Gly Phe Pro Asp Pro Gly Lys Lys Ala 
            20                  25                  30          


Ser Pro Leu Val Val Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Gln 
        35                  40                  45              


Gly Val Pro Gln His Leu Leu Pro Pro Phe His Ala Pro Leu Pro Ile 
    50                  55                  60                  


Asp Met Arg His Gln Glu Gly Arg Tyr His Tyr Glu Pro His Ser Val 
65                  70                  75                  80  


His Gly Val His Gly Pro Pro Ala Leu Ser Gly Ser Pro Val Ile Ser 
                85                  90                  95      


Asp Ile Ser Leu Ile Arg Leu Ser Pro His Pro Ala Gly Pro Gly Glu 
            100                 105                 110         


Ser Pro Phe Asn Ala Pro His Pro Tyr Val Asn Pro His Met Glu His 
        115                 120                 125             


Tyr Leu Arg Ser Val His Ser Ser Pro Thr Leu Ser Met Ile Ser Ala 
    130                 135                 140                 


Ala Arg Gly Leu Ser Pro Ala Asp Val Ala Gln Glu His Leu Lys Glu 
145                 150                 155                 160 


Arg Gly Leu Phe Gly Leu Pro Ala Pro Gly Thr Thr Pro Ser Asp Tyr 
                165                 170                 175     


Tyr His Gln Met Thr Leu Val Ala Gly His Pro Ala Pro Tyr Gly Asp 
            180                 185                 190         


Leu Leu Met Gln Ser Gly Gly Ala Ala Ser Ala Pro His Leu His Asp 
        195                 200                 205             


Tyr Leu Asn Pro Val Asp Val Ser Arg Phe Ser Ser Pro Arg Val Thr 
    210                 215                 220                 


Pro Arg Leu Ser Arg Lys Arg Ala Leu Ser Ile Ser Pro Leu Ser Asp 
225                 230                 235                 240 


Ala Ser Leu Asp Leu Gln Arg Met Ile Arg Thr Ser Pro Asn Ser Leu 
                245                 250                 255     


Val Ala Tyr Ile Asn Asn Ser Arg Ser Ser Ser Ala Ala Ser Gly Ser 
            260                 265                 270         


Tyr Gly His Leu Ser Ala Gly Ala Leu Ser Pro Ala Phe Thr Phe Pro 
        275                 280                 285             


His Pro Ile Asn Pro Val Ala Tyr Gln Gln Ile Leu Ser Gln Gln Arg 
    290                 295                 300                 


Gly Leu Gly Ser Ala Phe Gly His Thr Pro Pro Leu Ile Gln Pro Ser 
305                 310                 315                 320 


Pro Thr Phe Leu Ala Gln Gln Pro Met Ala Leu Thr Ser Ile Asn Ala 
                325                 330                 335     


Thr Pro Thr Gln Leu Ser Ser Ser Ser Asn Cys Leu Ser Asp Thr Asn 
            340                 345                 350         


Gln Asn Lys Gln Ser Ser Glu Ser Ala Val Ser Ser Thr Val Asn Pro 
        355                 360                 365             


Val Ala Ile His Lys Arg Ser Lys Val Lys Thr Glu Pro Glu Gly Leu 
    370                 375                 380                 


Arg Pro Ala Ser Pro Leu Ala Leu Thr Gln Gly Gln Val Ser Gly His 
385                 390                 395                 400 


Gly Ser Cys Gly Cys Ala Leu Pro Leu Ser Gln Glu Gln Leu Ala Asp 
                405                 410                 415     


Leu Lys Glu Asp Leu Asp Arg Asp Asp Cys Lys Gln Glu Ala Glu Val 
            420                 425                 430         


Val Ile Tyr Glu Thr Asn Cys His Trp Glu Asp Cys Thr Lys Glu Tyr 
        435                 440                 445             


Asp Thr Gln Glu Gln Leu Val His His Ile Asn Asn Glu His Ile His 
    450                 455                 460                 


Gly Glu Lys Lys Glu Phe Val Cys Arg Trp Gln Ala Cys Thr Arg Glu 
465                 470                 475                 480 


Gln Lys Pro Phe Lys Ala Gln Tyr Met Leu Val Val His Met Arg Arg 
                485                 490                 495     


His Thr Gly Glu Lys Pro His Lys Cys Thr Phe Glu Gly Cys Ser Lys 
            500                 505                 510         


Ala Tyr Ser Arg Leu Glu Asn Leu Lys Thr His Leu Arg Ser His Thr 
        515                 520                 525             


Gly Glu Lys Pro Tyr Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe 
    530                 535                 540                 


Ser Asn Ala Ser Asp Arg Ala Lys His Gln Asn Arg Thr His Ser Asn 
545                 550                 555                 560 


Glu Lys Pro Tyr Ile Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr 
                565                 570                 575     


Asp Pro Ser Ser Leu Arg Lys His Val Lys Thr Val His Gly Pro Asp 
            580                 585                 590         


Ala His Val Thr Lys Lys Gln Arg Asn Asp Val His Leu Arg Thr Pro 
        595                 600                 605             


Leu Leu Lys Glu Asn Gly Asp Ser Glu Ala Gly Thr Glu Pro Gly Gly 
    610                 615                 620                 


Pro Glu Ser Thr Glu Ala Ser Ser Thr Ser Gln Ala Val Glu Asp Cys 
625                 630                 635                 640 


Leu His Val Arg Ala Ile Lys Thr Glu Ser Ser Gly Leu Cys Gln Ser 
                645                 650                 655     


Ser Pro Gly Ala Gln Ser Ser Cys Ser Ser Glu Pro Ser Pro Leu Gly 
            660                 665                 670         


Ser Ala Pro Asn Asn Asp Ser Gly Val Glu Met Pro Gly Thr Gly Pro 
        675                 680                 685             


Gly Ser Leu Gly Asp Leu Thr Ala Leu Asp Asp Thr Pro Pro Gly Ala 
    690                 695                 700                 


Asp Thr Ser Ala Leu Ala Ala Pro Ser Ala Gly Gly Leu Gln Leu Arg 
705                 710                 715                 720 


Lys His Met Thr Thr Met His Arg Phe Glu Gln Leu Lys Lys Glu Lys 
                725                 730                 735     


Leu Lys Ser Leu Lys Asp Ser Cys Ser Trp Ala Gly Pro Thr Pro His 
            740                 745                 750         


Thr Arg Asn Thr Lys Leu Pro Pro Leu Pro Gly Ser Gly Ser Ile Leu 
        755                 760                 765             


Glu Asn Phe Ser Gly Ser Gly Gly Gly Gly Pro Ala Gly Leu Leu Pro 
    770                 775                 780                 


Asn Pro Arg Leu Ser Glu Leu Ser Ala Ser Glu Val Thr Met Leu Ser 
785                 790                 795                 800 


Gln Leu Gln Glu Arg Arg Asp Ser Ser Thr Ser Thr Val Ser Ser Ala 
                805                 810                 815     


Tyr Thr Val Ser Arg Arg Ser Ser Gly Ile Ser Pro Tyr Phe Ser Ser 
            820                 825                 830         


Arg Arg Ser Ser Glu Ala Ser Pro Leu Gly Ala Gly Arg Pro His Asn 
        835                 840                 845             


Ala Ser Ser Ala Asp Ser Tyr Asp Pro Ile Ser Thr Asp Ala Ser Arg 
    850                 855                 860                 


Arg Ser Ser Glu Ala Ser Gln Cys Ser Gly Gly Ser Gly Leu Leu Asn 
865                 870                 875                 880 


Leu Thr Pro Ala Gln Gln Tyr Ser Leu Arg Ala Lys Tyr Ala Ala Ala 
                885                 890                 895     


Thr Gly Gly Pro Pro Pro Thr Pro Leu Pro Gly Leu Glu Arg Met Ser 
            900                 905                 910         


Leu Arg Thr Arg Leu Ala Leu Leu Asp Ala Pro Glu Arg Thr Leu Pro 
        915                 920                 925             


Ala Gly Cys Pro Arg Pro Leu Gly Pro Arg Arg Gly Ser Asp Gly Pro 
    930                 935                 940                 


Thr Tyr Gly His Gly His Ala Gly Ala Ala Pro Ala Phe Pro His Glu 
945                 950                 955                 960 


Ala Pro Gly Gly Gly Ala Arg Arg Ala Ser Asp Pro Val Arg Arg Pro 
                965                 970                 975     


Asp Ala Leu Ser Leu Pro Arg Val Gln Arg Phe His Ser Thr His Asn 
            980                 985                 990         


Val Asn Pro Gly Pro Leu Pro Pro  Cys Ala Asp Arg Arg  Gly Leu Arg 
        995                 1000                 1005             


Leu Gln  Ser His Pro Ser Thr  Asp Gly Gly Leu Ala  Arg Gly Ala 
    1010                 1015                 1020             


Tyr Ser  Pro Arg Pro Pro Ser  Ile Ser Glu Asn Val  Ala Met Glu 
    1025                 1030                 1035             


Ala Val  Ala Ala Gly Val Asp  Gly Ala Gly Pro Glu  Ala Asp Leu 
    1040                 1045                 1050             


Gly Leu  Pro Glu Asp Asp Leu  Val Leu Pro Asp Asp  Val Val Gln 
    1055                 1060                 1065             


Tyr Ile  Lys Ala His Ala Ser  Gly Ala Leu Asp Glu  Gly Thr Gly 
    1070                 1075                 1080             


Gln Val  Tyr Pro Thr Glu Ser  Thr Gly Phe Ser Asp  Asn Pro Arg 
    1085                 1090                 1095             


Leu Pro  Ser Pro Gly Leu His  Gly Gln Arg Arg Met  Val Ala Ala 
    1100                 1105                 1110             


Asp Ser  Asn Val Gly Pro Ser  Ala Pro Met Leu Gly  Gly Cys Gln 
    1115                 1120                 1125             


Leu Gly  Phe Gly Ala Pro Ser  Ser Leu Asn Lys Asn  Asn Met Pro 
    1130                 1135                 1140             


Val Gln  Trp Asn Glu Val Ser  Ser Gly Thr Val Asp  Ala Leu Ala 
    1145                 1150                 1155             


Ser Gln  Val Lys Pro Pro Pro  Phe Pro Gln Gly Asn  Leu Ala Val 
    1160                 1165                 1170             


Val Gln  Gln Lys Pro Ala Phe  Gly Gln Tyr Pro Gly  Tyr Ser Pro 
    1175                 1180                 1185             


Gln Gly  Leu Gln Ala Ser Pro  Gly Gly Leu Asp Ser  Thr Gln Pro 
    1190                 1195                 1200             


His Leu  Gln Pro Arg Ser Gly  Ala Pro Ser Gln Gly  Ile Pro Arg 
    1205                 1210                 1215             


Val Asn  Tyr Met Gln Gln Leu  Arg Gln Pro Val Ala  Gly Ser Gln 
    1220                 1225                 1230             


Cys Pro  Gly Met Thr Thr Thr  Met Ser Pro His Ala  Cys Tyr Gly 
    1235                 1240                 1245             


Gln Val  His Pro Gln Leu Ser  Pro Ser Thr Ile Ser  Gly Ala Leu 
    1250                 1255                 1260             


Asn Gln  Phe Pro Gln Ser Cys  Ser Asn Met Pro Ala  Lys Pro Gly 
    1265                 1270                 1275             


His Leu  Gly His Pro Gln Gln  Thr Glu Val Ala Pro  Asp Pro Thr 
    1280                 1285                 1290             


Thr Met  Gly Asn Arg His Arg  Glu Leu Gly Val Pro  Asp Ser Ala 
    1295                 1300                 1305             


Leu Ala  Gly Val Pro Pro Pro  His Pro Val Gln Ser  Tyr Pro Gln 
    1310                 1315                 1320             


Gln Ser  His His Leu Ala Ala  Ser Met Ser Gln Glu  Gly Tyr His 
    1325                 1330                 1335             


Gln Val  Pro Ser Leu Leu Pro  Ala Arg Gln Pro Gly  Phe Met Glu 
    1340                 1345                 1350             


Pro Gln  Thr Gly Pro Met Gly  Val Ala Thr Ala Gly  Phe Gly Leu 
    1355                 1360                 1365             


Val Gln  Pro Arg Pro Pro Leu  Glu Pro Ser Pro Thr  Gly Arg His 
    1370                 1375                 1380             


Arg Gly  Val Arg Ala Val Gln  Gln Gln Leu Ala Tyr  Ala Arg Ala 
    1385                 1390                 1395             


Thr Gly  His Ala Met Ala Ala  Met Pro Ser Ser Gln  Glu Thr Ala 
    1400                 1405                 1410             


Glu Ala  Val Pro Lys Gly Ala  Met Gly Asn Met Gly  Ser Val Pro 
    1415                 1420                 1425             


Pro Gln  Pro Pro Pro Gln Asp  Ala Gly Gly Ala Pro  Asp His Ser 
    1430                 1435                 1440             


Met Leu  Tyr Tyr Tyr Gly Gln  Ile His Met Tyr Glu  Gln Asp Gly 
    1445                 1450                 1455             


Gly Leu  Glu Asn Leu Gly Ser  Cys Gln Val Met Arg  Ser Gln Pro 
    1460                 1465                 1470             


Pro Gln  Pro Gln Ala Cys Gln  Asp Ser Ile Gln Pro  Gln Pro Leu 
    1475                 1480                 1485             


Pro Ser  Pro Gly Val Asn Gln  Val Ser Ser Thr Val  Asp Ser Gln 
    1490                 1495                 1500             


Leu Leu  Glu Ala Pro Gln Ile  Asp Phe Asp Ala Ile  Met Asp Asp 
    1505                 1510                 1515             


Gly Asp  His Ser Ser Leu Phe  Ser Gly Ala Leu Ser  Pro Ser Leu 
    1520                 1525                 1530             


Leu His  Ser Leu Ser Gln Asn  Ser Ser Arg Leu Thr  Thr Pro Arg 
    1535                 1540                 1545             


Asn Ser  Leu Thr Leu Pro Ser  Ile Pro Ala Gly Ile  Ser Asn Met 
    1550                 1555                 1560             


Ala Val  Gly Asp Met Ser Ser  Met Leu Thr Ser Leu  Ala Glu Glu 
    1565                 1570                 1575             


Ser Lys  Phe Leu Asn Met Met  Thr 
    1580                 1585     


<210>  4488
<211>  1580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLI3__Homo_sapiens__XP_011513575

<400>  4488

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15      


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30          


Ala Val Ala Ser Ser Thr Thr Ser Asn Glu Asp Glu Ser Pro Gly Gln 
        35                  40                  45              


Thr Tyr His Arg Glu Arg Arg Asn Ala Ile Thr Met Gln Pro Gln Asn 
    50                  55                  60                  


Val Gln Gly Leu Ser Lys Val Ser Glu Glu Pro Ser Thr Ser Ser Asp 
65                  70                  75                  80  


Glu Arg Ala Ser Leu Ile Lys Lys Glu Ile His Gly Ser Leu Pro His 
                85                  90                  95      


Val Ala Glu Pro Ser Val Pro Tyr Arg Gly Thr Val Phe Ala Met Asp 
            100                 105                 110         


Pro Arg Asn Gly Tyr Met Glu Pro His Tyr His Pro Pro His Leu Phe 
        115                 120                 125             


Pro Ala Phe His Pro Pro Val Pro Ile Asp Ala Arg His His Glu Gly 
    130                 135                 140                 


Arg Tyr His Tyr Asp Pro Ser Pro Ile Pro Pro Leu His Met Thr Ser 
145                 150                 155                 160 


Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe Ile Arg Ile 
                165                 170                 175     


Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro Phe Ser Pro 
            180                 185                 190         


Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg Ser Leu His 
        195                 200                 205             


Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly Leu Ser Pro 
    210                 215                 220                 


Thr Asp Ala Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His Gln 
225                 230                 235                 240 


Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile Pro 
                245                 250                 255     


Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu His 
            260                 265                 270         


Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg Pro 
        275                 280                 285             


Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser Phe 
    290                 295                 300                 


Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr Ile 
305                 310                 315                 320 


Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly His 
                325                 330                 335     


Leu Ser Ala Ser Ala Ile Ser Pro Ala Leu Ser Phe Thr Tyr Ser Ser 
            340                 345                 350         


Ala Pro Val Ser Leu His Met His Gln Gln Ile Leu Ser Arg Gln Gln 
        355                 360                 365             


Ser Leu Gly Ser Ala Phe Gly His Ser Pro Pro Leu Ile His Pro Ala 
    370                 375                 380                 


Pro Thr Phe Pro Thr Gln Arg Pro Ile Pro Gly Ile Pro Thr Val Leu 
385                 390                 395                 400 


Asn Pro Val Gln Val Ser Ser Gly Pro Ser Glu Ser Ser Gln Asn Lys 
                405                 410                 415     


Pro Thr Ser Glu Ser Ala Val Ser Ser Thr Gly Asp Pro Met His Asn 
            420                 425                 430         


Lys Arg Ser Lys Ile Lys Pro Asp Glu Asp Leu Pro Ser Pro Gly Ala 
        435                 440                 445             


Arg Gly Gln Gln Glu Gln Pro Glu Gly Thr Thr Leu Val Lys Glu Glu 
    450                 455                 460                 


Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile Tyr Glu Thr 
465                 470                 475                 480 


Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr Gln Glu Gln 
                485                 490                 495     


Leu Val His His Ile Asn Asn Asp His Ile His Gly Glu Lys Lys Glu 
            500                 505                 510         


Phe Val Cys Arg Trp Leu Asp Cys Ser Arg Glu Gln Lys Pro Phe Lys 
        515                 520                 525             


Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly Glu Lys 
    530                 535                 540                 


Pro His Lys Cys Thr Phe Glu Gly Cys Thr Lys Ala Tyr Ser Arg Leu 
545                 550                 555                 560 


Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr 
                565                 570                 575     


Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe Ser Asn Ala Ser Asp 
            580                 585                 590         


Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val 
        595                 600                 605             


Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu 
    610                 615                 620                 


Arg Lys His Val Lys Thr Val His Gly Pro Glu Ala His Val Thr Lys 
625                 630                 635                 640 


Lys Gln Arg Gly Asp Ile His Pro Arg Pro Pro Pro Pro Arg Asp Ser 
                645                 650                 655     


Gly Ser His Ser Gln Ser Arg Ser Pro Gly Arg Pro Thr Gln Gly Ala 
            660                 665                 670         


Leu Gly Glu Gln Gln Asp Leu Ser Asn Thr Thr Ser Lys Arg Glu Glu 
        675                 680                 685             


Cys Leu Gln Val Lys Thr Val Lys Ala Glu Lys Pro Met Thr Ser Gln 
    690                 695                 700                 


Pro Ser Pro Gly Gly Gln Ser Ser Cys Ser Ser Gln Gln Ser Pro Ile 
705                 710                 715                 720 


Ser Asn Tyr Ser Asn Ser Gly Leu Glu Leu Pro Leu Thr Asp Gly Gly 
                725                 730                 735     


Ser Ile Gly Asp Leu Ser Ala Ile Asp Glu Thr Pro Ile Met Asp Ser 
            740                 745                 750         


Thr Ile Ser Thr Ala Thr Thr Ala Leu Ala Leu Gln Ala Arg Arg Asn 
        755                 760                 765             


Pro Ala Gly Thr Lys Trp Met Glu His Val Lys Leu Glu Arg Leu Lys 
    770                 775                 780                 


Gln Val Asn Gly Met Phe Pro Arg Leu Asn Pro Ile Leu Pro Pro Lys 
785                 790                 795                 800 


Ala Pro Ala Val Ser Pro Leu Ile Gly Asn Gly Thr Gln Ser Asn Asn 
                805                 810                 815     


Thr Cys Ser Leu Gly Gly Pro Met Thr Leu Leu Pro Gly Arg Ser Asp 
            820                 825                 830         


Leu Ser Gly Val Asp Val Thr Met Leu Asn Met Leu Asn Arg Arg Asp 
        835                 840                 845             


Ser Ser Ala Ser Thr Ile Ser Ser Ala Tyr Leu Ser Ser Arg Arg Ser 
    850                 855                 860                 


Ser Gly Ile Ser Pro Cys Phe Ser Ser Arg Arg Ser Ser Glu Ala Ser 
865                 870                 875                 880 


Gln Ala Glu Gly Arg Pro Gln Asn Val Ser Val Ala Asp Ser Tyr Asp 
                885                 890                 895     


Pro Ile Ser Thr Asp Ala Ser Arg Arg Ser Ser Glu Ala Ser Gln Ser 
            900                 905                 910         


Asp Gly Leu Pro Ser Leu Leu Ser Leu Thr Pro Ala Gln Gln Tyr Arg 
        915                 920                 925             


Leu Lys Ala Lys Tyr Ala Ala Ala Thr Gly Gly Pro Pro Pro Thr Pro 
    930                 935                 940                 


Leu Pro Asn Met Glu Arg Met Ser Leu Lys Thr Arg Leu Ala Leu Leu 
945                 950                 955                 960 


Gly Asp Ala Leu Glu Pro Gly Val Ala Leu Pro Pro Val His Ala Pro 
                965                 970                 975     


Arg Arg Cys Ser Asp Gly Gly Ala His Gly Tyr Gly Arg Arg His Leu 
            980                 985                 990         


Gln Pro His Asp Ala Pro Gly His  Gly Val Arg Arg Ala  Ser Asp Pro 
        995                 1000                 1005             


Val Arg  Thr Gly Ser Glu Gly  Leu Ala Leu Pro Arg  Val Pro Arg 
    1010                 1015                 1020             


Phe Ser  Ser Leu Ser Ser Cys  Asn Pro Pro Ala Met  Ala Thr Ser 
    1025                 1030                 1035             


Ala Glu  Lys Arg Ser Leu Val  Leu Gln Asn Tyr Thr  Arg Pro Glu 
    1040                 1045                 1050             


Gly Gly  Gln Ser Arg Asn Phe  His Ser Ser Pro Cys  Pro Pro Ser 
    1055                 1060                 1065             


Ile Thr  Glu Asn Val Thr Leu  Glu Ser Leu Thr Met  Asp Ala Asp 
    1070                 1075                 1080             


Ala Asn  Leu Asn Asp Glu Asp  Phe Leu Pro Asp Asp  Val Val Gln 
    1085                 1090                 1095             


Tyr Leu  Asn Ser Gln Asn Gln  Ala Gly Tyr Glu Gln  His Phe Pro 
    1100                 1105                 1110             


Ser Ala  Leu Pro Asp Asp Ser  Lys Val Pro His Gly  Pro Gly Asp 
    1115                 1120                 1125             


Phe Asp  Ala Pro Gly Leu Pro  Asp Ser His Ala Gly  Gln Gln Phe 
    1130                 1135                 1140             


His Ala  Leu Glu Gln Pro Cys  Pro Glu Gly Ser Lys  Thr Asp Leu 
    1145                 1150                 1155             


Pro Ile  Gln Trp Asn Glu Val  Ser Ser Gly Ser Ala  Asp Leu Ser 
    1160                 1165                 1170             


Ser Ser  Lys Leu Lys Cys Gly  Pro Arg Pro Ala Val  Pro Gln Thr 
    1175                 1180                 1185             


Arg Ala  Phe Gly Phe Cys Asn  Gly Met Val Val His  Pro Gln Asn 
    1190                 1195                 1200             


Pro Leu  Arg Ser Gly Pro Ala  Gly Gly Tyr Gln Thr  Leu Gly Glu 
    1205                 1210                 1215             


Asn Ser  Asn Pro Tyr Gly Gly  Pro Glu His Leu Met  Leu His Asn 
    1220                 1225                 1230             


Ser Pro  Gly Ser Gly Thr Ser  Gly Asn Ala Phe His  Glu Gln Pro 
    1235                 1240                 1245             


Cys Lys  Ala Pro Gln Tyr Gly  Asn Cys Leu Asn Arg  Gln Pro Val 
    1250                 1255                 1260             


Ala Pro  Gly Ala Leu Asp Gly  Ala Cys Gly Ala Gly  Ile Gln Ala 
    1265                 1270                 1275             


Ser Lys  Leu Lys Ser Thr Pro  Met Gln Gly Ser Gly  Gly Gln Leu 
    1280                 1285                 1290             


Asn Phe  Gly Leu Pro Val Ala  Pro Asn Glu Ser Ala  Gly Ser Met 
    1295                 1300                 1305             


Val Asn  Gly Met Gln Asn Gln  Asp Pro Val Gly Gln  Gly Tyr Leu 
    1310                 1315                 1320             


Ala His  Gln Leu Leu Gly Asp  Ser Met Gln His Pro  Gly Ala Gly 
    1325                 1330                 1335             


Arg Pro  Gly Gln Gln Met Leu  Gly Gln Ile Ser Ala  Thr Ser His 
    1340                 1345                 1350             


Ile Asn  Ile Tyr Gln Gly Pro  Glu Ser Cys Leu Pro  Gly Ala His 
    1355                 1360                 1365             


Gly Met  Gly Ser Gln Pro Ser  Ser Leu Ala Val Val  Arg Gly Tyr 
    1370                 1375                 1380             


Gln Pro  Cys Ala Ser Phe Gly  Gly Ser Arg Arg Gln  Ala Met Pro 
    1385                 1390                 1395             


Arg Asp  Ser Leu Ala Leu Gln  Ser Gly Gln Leu Ser  Asp Thr Ser 
    1400                 1405                 1410             


Gln Thr  Cys Arg Val Asn Gly  Ile Lys Met Glu Met  Lys Gly Gln 
    1415                 1420                 1425             


Pro His  Pro Leu Cys Ser Asn  Leu Gln Asn Tyr Ser  Gly Gln Phe 
    1430                 1435                 1440             


Tyr Asp  Gln Thr Val Gly Phe  Ser Gln Gln Asp Thr  Lys Ala Gly 
    1445                 1450                 1455             


Ser Phe  Ser Ile Ser Asp Ala  Ser Cys Leu Leu Gln  Gly Thr Ser 
    1460                 1465                 1470             


Ala Lys  Asn Ser Glu Leu Leu  Ser Pro Gly Ala Asn  Gln Val Thr 
    1475                 1480                 1485             


Ser Thr  Val Asp Ser Leu Asp  Ser His Asp Leu Glu  Gly Val Gln 
    1490                 1495                 1500             


Ile Asp  Phe Asp Ala Ile Ile  Asp Asp Gly Asp His  Ser Ser Leu 
    1505                 1510                 1515             


Met Ser  Gly Ala Leu Ser Pro  Ser Ile Ile Gln Asn  Leu Ser His 
    1520                 1525                 1530             


Ser Ser  Ser Arg Leu Thr Thr  Pro Arg Ala Ser Leu  Pro Phe Pro 
    1535                 1540                 1545             


Ala Leu  Ser Met Ser Thr Thr  Asn Met Ala Ile Gly  Asp Met Ser 
    1550                 1555                 1560             


Ser Leu  Leu Thr Ser Leu Ala  Glu Glu Ser Lys Phe  Leu Ala Val 
    1565                 1570                 1575             


Met Gln  
    1580 


<210>  4489
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLIPR1__Homo_sapiens__NP_006842

<400>  4489

Met Arg Val Thr Leu Ala Thr Ile Ala Trp Met Val Ser Phe Val Ser 
1               5                   10                  15      


Asn Tyr Ser His Thr Ala Asn Ile Leu Pro Asp Ile Glu Asn Glu Asp 
            20                  25                  30          


Phe Ile Lys Asp Cys Val Arg Ile His Asn Lys Phe Arg Ser Glu Val 
        35                  40                  45              


Lys Pro Thr Ala Ser Asp Met Leu Tyr Met Thr Trp Asp Pro Ala Leu 
    50                  55                  60                  


Ala Gln Ile Ala Lys Ala Trp Ala Ser Asn Cys Gln Phe Ser His Asn 
65                  70                  75                  80  


Thr Arg Leu Lys Pro Pro His Lys Leu His Pro Asn Phe Thr Ser Leu 
                85                  90                  95      


Gly Glu Asn Ile Trp Thr Gly Ser Val Pro Ile Phe Ser Val Ser Ser 
            100                 105                 110         


Ala Ile Thr Asn Trp Tyr Asp Glu Ile Gln Asp Tyr Asp Phe Lys Thr 
        115                 120                 125             


Arg Ile Cys Lys Lys Val Cys Gly His Tyr Thr Gln Val Val Trp Ala 
    130                 135                 140                 


Asp Ser Tyr Lys Val Gly Cys Ala Val Gln Phe Cys Pro Lys Val Ser 
145                 150                 155                 160 


Gly Phe Asp Ala Leu Ser Asn Gly Ala His Phe Ile Cys Asn Tyr Gly 
                165                 170                 175     


Pro Gly Gly Asn Tyr Pro Thr Trp Pro Tyr Lys Arg Gly Ala Thr Cys 
            180                 185                 190         


Ser Ala Cys Pro Asn Asn Asp Lys Cys Leu Asp Asn Leu Cys Val Asn 
        195                 200                 205             


Arg Gln Arg Asp Gln Val Lys Arg Tyr Tyr Ser Val Val Tyr Pro Gly 
    210                 215                 220                 


Trp Pro Ile Tyr Pro Arg Asn Arg Tyr Thr Ser Leu Phe Leu Ile Val 
225                 230                 235                 240 


Asn Ser Val Ile Leu Ile Leu Ser Val Ile Ile Thr Ile Leu Val Gln 
                245                 250                 255     


His Lys Tyr Pro Asn Leu Val Leu Leu Asp 
            260                 265     


<210>  4490
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLIPR2__Homo_sapiens__NP_001273939

<400>  4490

Met Gly Lys Ser Ala Ser Lys Gln Phe His Asn Glu Val Leu Lys Ala 
1               5                   10                  15      


His Asn Glu Tyr Arg Gln Lys His Gly Val Pro Pro Leu Lys Leu Cys 
            20                  25                  30          


Lys Asn Leu Asn Arg Glu Ala Gln Gln Tyr Ser Glu Ala Leu Ala Ser 
        35                  40                  45              


Thr Arg Ile Leu Lys His Ser Pro Glu Ser Ser Arg Gly Gln Cys Gly 
    50                  55                  60                  


Glu Asn Leu Ala Trp Ala Ser Tyr Asp Gln Thr Gly His Phe Thr Ala 
65                  70                  75                  80  


Met Val Trp Lys Asn Thr Lys Lys Met Gly Val Gly Lys Ala Ser Ala 
                85                  90                  95      


Ser Asp Gly Ser Ser Phe Val Val Ala Arg Tyr Phe Pro Ala Gly Asn 
            100                 105                 110         


Val Val Asn Glu Gly Phe Phe Glu Glu Asn Val Leu Pro Pro Lys Lys 
        115                 120                 125             


<210>  4491
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLIS2__Homo_sapiens__NP_001305847

<400>  4491

Met His Ser Leu Asp Glu Pro Leu Asp Leu Lys Leu Ser Ile Thr Lys 
1               5                   10                  15      


Leu Arg Ala Ala Arg Glu Lys Arg Glu Arg Thr Leu Gly Val Val Arg 
            20                  25                  30          


Pro Arg Ala Leu His Arg Glu Leu Gly Leu Val Asp Asp Ser Pro Thr 
        35                  40                  45              


Pro Gly Ser Pro Gly Ser Pro Pro Ser Gly Phe Leu Leu Asn Ser Lys 
    50                  55                  60                  


Phe Pro Glu Lys Val Glu Gly Arg Phe Ser Ala Ala Pro Leu Val Asp 
65                  70                  75                  80  


Leu Ser Leu Ser Pro Pro Ser Gly Leu Asp Ser Pro Asn Gly Ser Ser 
                85                  90                  95      


Ser Leu Ser Pro Glu Arg Gln Gly Asn Gly Asp Leu Pro Pro Val Pro 
            100                 105                 110         


Ser Ala Ser Asp Phe Gln Pro Leu Arg Tyr Leu Asp Gly Val Pro Ser 
        115                 120                 125             


Ser Phe Gln Phe Phe Leu Pro Leu Gly Ser Gly Gly Ala Leu His Leu 
    130                 135                 140                 


Pro Ala Ser Ser Phe Leu Thr Pro Pro Lys Asp Lys Cys Leu Ser Pro 
145                 150                 155                 160 


Asp Leu Pro Leu Pro Lys Gln Leu Val Cys Arg Trp Ala Lys Cys Asn 
                165                 170                 175     


Gln Leu Phe Glu Leu Leu Gln Asp Leu Val Asp His Val Asn Asp Tyr 
            180                 185                 190         


His Val Lys Pro Glu Lys Asp Ala Gly Tyr Cys Cys His Trp Glu Gly 
        195                 200                 205             


Cys Ala Arg His Gly Arg Gly Phe Asn Ala Arg Tyr Lys Met Leu Ile 
    210                 215                 220                 


His Ile Arg Thr His Thr Asn Glu Lys Pro His Arg Cys Pro Thr Cys 
225                 230                 235                 240 


Ser Lys Ser Phe Ser Arg Leu Glu Asn Leu Lys Ile His Asn Arg Ser 
                245                 250                 255     


His Thr Gly Glu Lys Pro Tyr Val Cys Pro Tyr Glu Gly Cys Asn Lys 
            260                 265                 270         


Arg Tyr Ser Asn Ser Ser Asp Arg Phe Lys His Thr Arg Thr His Tyr 
        275                 280                 285             


Val Asp Lys Pro Tyr Tyr Cys Lys Met Pro Gly Cys His Lys Arg Tyr 
    290                 295                 300                 


Thr Asp Pro Ser Ser Leu Arg Lys His Ile Lys Ala His Gly His Phe 
305                 310                 315                 320 


Val Ser His Glu Gln Gln Glu Leu Leu Gln Leu Arg Pro Pro Pro Lys 
                325                 330                 335     


Pro Pro Leu Pro Ala Pro Asp Gly Gly Pro Tyr Val Ser Gly Ala Gln 
            340                 345                 350         


Ile Ile Ile Pro Asn Pro Ala Ala Leu Phe Gly Gly Pro Gly Leu Pro 
        355                 360                 365             


Gly Leu Pro Leu Pro Leu Ala Pro Gly Pro Leu Asp Leu Ser Ala Leu 
    370                 375                 380                 


Ala Cys Gly Asn Gly Gly Gly Ser Gly Gly Gly Gly Gly Met Gly Pro 
385                 390                 395                 400 


Gly Leu Pro Gly Pro Val Leu Pro Leu Asn Leu Ala Lys Asn Pro Leu 
                405                 410                 415     


Leu Pro Ser Pro Phe Gly Ala Gly Gly Leu Gly Leu Pro Val Val Ser 
            420                 425                 430         


Leu Leu Ala Gly Ala Ala Gly Gly Lys Ala Glu Gly Glu Lys Gly Arg 
        435                 440                 445             


Gly Ser Val Pro Thr Arg Ala Leu Gly Met Glu Gly His Lys Thr Pro 
    450                 455                 460                 


Leu Glu Arg Thr Glu Ser Ser Cys Ser Arg Pro Ser Pro Asp Gly Leu 
465                 470                 475                 480 


Pro Leu Leu Pro Gly Thr Val Leu Asp Leu Ser Thr Gly Val Asn Ser 
                485                 490                 495     


Ala Ala Ser Ser Pro Glu Ala Leu Ala Pro Gly Trp Val Val Ile Pro 
            500                 505                 510         


Pro Gly Ser Val Leu Leu Lys Pro Ala Val Val Asn 
        515                 520                 


<210>  4492
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLIS3__Homo_sapiens__XP_006716794

<400>  4492

Met Asn Gly Arg Ser Cys Ser Met Ser Leu His Arg Thr Ser Gly Thr 
1               5                   10                  15      


Pro Gln Gly Pro Arg Met Val Ser Gly His His Ile Pro Ala Ile Arg 
            20                  25                  30          


Ala His Ser Gly Thr Pro Gly Pro Ser Pro Cys Gly Ser Thr Ser Ser 
        35                  40                  45              


Pro Thr Met Ala Ser Leu Ala Asn Asn Leu His Leu Lys Met Pro Ser 
    50                  55                  60                  


Gly Gly Gly Met Ala Pro Gln Asn Asn Val Ala Glu Ser Arg Ile His 
65                  70                  75                  80  


Leu Pro Ala Leu Ser Pro Arg Arg Gln Met Leu Thr Asn Gly Lys Pro 
                85                  90                  95      


Arg Phe Gln Val Thr Gln Ala Gly Gly Met Ser Gly Ser His Thr Leu 
            100                 105                 110         


Lys Pro Lys Gln Gln Glu Phe Gly Ser Pro Phe Pro Pro Asn Pro Gly 
        115                 120                 125             


Lys Gly Ala Leu Gly Phe Gly Pro Gln Cys Lys Ser Ile Gly Lys Gly 
    130                 135                 140                 


Ser Cys Asn Asn Leu Val Val Thr Ser Ser Pro Met Met Val Gln Arg 
145                 150                 155                 160 


Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val Ser Thr Ala Cys Asn 
                165                 170                 175     


Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn Ala Ala Asn Leu Asn 
            180                 185                 190         


Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser Arg Glu Ser Leu Ala 
        195                 200                 205             


Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser Ala Ser Ser Met Lys 
    210                 215                 220                 


Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro Ser Leu Ser Asn His 
225                 230                 235                 240 


Gly Ser Gln Asn Gly Leu Asp Leu Gly Asp Leu Leu Ser Leu Pro Pro 
                245                 250                 255     


Gly Thr Ser Met Ser Ser Asn Ser Val Ser Asn Ser Leu Pro Ser Tyr 
            260                 265                 270         


Leu Phe Gly Thr Glu Ser Ser His Ser Pro Tyr Pro Ser Pro Arg His 
        275                 280                 285             


Ser Ser Thr Arg Ser His Ser Ala Arg Ser Lys Lys Arg Ala Leu Ser 
    290                 295                 300                 


Leu Ser Pro Leu Ser Asp Gly Ile Gly Ile Asp Phe Asn Thr Ile Ile 
305                 310                 315                 320 


Arg Thr Ser Pro Thr Ser Leu Val Ala Tyr Ile Asn Gly Ser Arg Ala 
                325                 330                 335     


Ser Pro Ala Asn Leu Ser Pro Gln Pro Glu Val Tyr Gly His Phe Leu 
            340                 345                 350         


Gly Val Arg Gly Ser Cys Ile Pro Gln Pro Arg Pro Val Pro Gly Ser 
        355                 360                 365             


Gln Lys Gly Val Leu Val Ala Pro Gly Gly Leu Ala Leu Pro Ala Tyr 
    370                 375                 380                 


Gly Glu Asp Gly Ala Leu Glu His Glu Arg Met Gln Gln Leu Glu His 
385                 390                 395                 400 


Gly Gly Leu Gln Pro Gly Leu Val Asn His Met Val Val Gln His Gly 
                405                 410                 415     


Leu Pro Gly Pro Asp Ser Gln Ser Ala Gly Leu Phe Lys Thr Glu Arg 
            420                 425                 430         


Leu Glu Glu Phe Pro Gly Ser Thr Val Asp Leu Pro Pro Ala Pro Pro 
        435                 440                 445             


Leu Pro Pro Leu Pro Pro Pro Pro Gly Pro Pro Pro Pro Tyr His Ala 
    450                 455                 460                 


His Ala His Leu His His Pro Glu Leu Gly Pro His Ala Gln Gln Leu 
465                 470                 475                 480 


Ala Leu Pro Gln Ala Thr Leu Asp Asp Asp Gly Glu Met Asp Gly Ile 
                485                 490                 495     


Gly Gly Lys His Cys Cys Arg Trp Ile Asp Cys Ser Ala Leu Tyr Asp 
            500                 505                 510         


Gln Gln Glu Glu Leu Val Arg His Ile Glu Lys Val His Ile Asp Gln 
        515                 520                 525             


Arg Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala Gly Cys Pro Arg Arg 
    530                 535                 540                 


Tyr Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu Ile His Met Arg Val 
545                 550                 555                 560 


His Ser Gly Glu Lys Pro Asn Lys Cys Thr Ala Ala 
                565                 570         


<210>  4493
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLMN__Homo_sapiens__XP_011538848

<400>  4493

Met Ala Val Glu Glu Leu Gln Ser Ile Ile Lys Arg Cys Gln Ile Leu 
1               5                   10                  15      


Glu Glu Gln Asp Phe Lys Glu Glu Asp Phe Gly Leu Phe Gln Leu Ala 
            20                  25                  30          


Gly Gln Arg Cys Ile Glu Glu Gly His Thr Asp Gln Leu Leu Glu Ile 
        35                  40                  45              


Ile Gln Asn Glu Lys Asn Lys Val Ile Ile Lys Asn Met Gly Trp Asn 
    50                  55                  60                  


Leu Val Gly Pro Val Val Arg Cys Leu Leu Cys Lys Asp Lys Glu Asp 
65                  70                  75                  80  


Ser Lys Arg Lys Val Tyr Phe Leu Ile Phe Asp Leu Leu Val Lys Leu 
                85                  90                  95      


Cys Asn Pro Lys Glu Leu Leu Leu Gly Leu Leu Glu Leu Ile Glu Glu 
            100                 105                 110         


Pro Ser Gly Lys Gln Ile Ser Gln Ser Ile Leu Leu Leu Leu Gln Pro 
        115                 120                 125             


Leu Gln Thr Val Ile Gln Lys Leu His Asn Lys Ala Tyr Ser Ile Gly 
    130                 135                 140                 


Leu Ala Leu Ser Thr Leu Trp Asn Gln Leu Ser Leu Leu Pro Val Pro 
145                 150                 155                 160 


Tyr Ser Lys Glu Gln Ile Gln Met Asp Asp Tyr Gly Leu Cys Gln Cys 
                165                 170                 175     


Cys Lys Ala Leu Ile Glu Phe Thr Lys Pro Phe Val Glu Glu Val Ile 
            180                 185                 190         


Asp Asn Lys Glu Asn Ser Leu Glu Asn Glu Lys Leu Lys Asp Glu Leu 
        195                 200                 205             


Leu Lys Phe Cys Phe Lys Ser Leu Lys Cys Pro Leu Leu Thr Ala Gln 
    210                 215                 220                 


Phe Phe Glu Gln Ser Glu Glu Gly Gly Asn Asp Pro Phe Arg Tyr Phe 
225                 230                 235                 240 


Ala Ser Glu Ile Ile Gly Phe Leu Ser Ala Ile Gly His Pro Phe Pro 
                245                 250                 255     


Lys Met Ile Phe Asn His Gly Arg Lys Lys Arg Thr Trp Asn Tyr Leu 
            260                 265                 270         


Glu Phe Glu Glu Glu Glu Asn Lys Gln Leu Ala Asp Ser Met Ala Ser 
        275                 280                 285             


Leu Ala Tyr Leu Val Phe Val Gln Gly Ile His Ile Asp Gln Leu Pro 
    290                 295                 300                 


Met Val Leu Ser Pro Leu Tyr Leu Leu Gln Phe Asn Met Gly His Ile 
305                 310                 315                 320 


Glu Val Phe Leu Gln Arg Thr Glu Glu Ser Val Ile Ser Lys Gly Leu 
                325                 330                 335     


Glu Leu Leu Glu Asn Ser Leu Leu Arg Ile Glu Asp Asn Ser Leu Leu 
            340                 345                 350         


Tyr Gln Tyr Leu Glu Ile Lys Ser Phe Leu Thr Val Pro Gln Gly Leu 
        355                 360                 365             


Val Lys Val Met Thr Leu Cys Pro Ile Glu Thr Leu Arg Lys Lys Ser 
    370                 375                 380                 


Leu Ala Met Leu Gln Leu Tyr Ile Asn Lys Leu Asp Ser Gln Gly Lys 
385                 390                 395                 400 


Tyr Thr Leu Phe Arg Cys Leu Leu Asn Thr Ser Asn His Ser Gly Val 
                405                 410                 415     


Glu Ala Phe Ile Ile Gln Asn Ile Lys Asn Gln Ile Asp Met Ser Leu 
            420                 425                 430         


Lys Arg Thr Arg Asn Asn Lys Trp Phe Thr Gly Pro Gln Leu Ile Ser 
        435                 440                 445             


Leu Leu Asp Leu Val Leu Phe Leu Pro Glu Gly Ala Glu Thr Asp Leu 
    450                 455                 460                 


Leu Gln Asn Ser Asp Arg Ile Met Ala Ser Leu Asn Leu Leu Arg Tyr 
465                 470                 475                 480 


Leu Val Ile Lys Asp Asn Glu Asn Asp Asn Gln Thr Gly Leu Trp Thr 
                485                 490                 495     


Glu Leu Gly Asn Ile Glu Asn Asn Phe Leu Lys Pro Leu His Ile Gly 
            500                 505                 510         


Leu Asn Met Ser Lys Ala His Tyr Glu Ala Glu Ile Lys Asn Ser Gln 
        515                 520                 525             


Glu Ala Gln Lys Ser Lys Asp Leu Cys Ser Ile Thr Val Ser Gly Glu 
    530                 535                 540                 


Glu Ile Pro Asn Met Pro Pro Glu Met Gln Leu Lys Val Leu His Ser 
545                 550                 555                 560 


Ala Leu Phe Thr Phe Asp Leu Ile Glu Ser Val Leu Ala Arg Val Glu 
                565                 570                 575     


Glu Leu Ile Glu Ile Lys Thr Lys Ser Thr Ser Glu Glu Asn Ile Gly 
            580                 585                 590         


Ile Lys 
        


<210>  4494
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLO1__Homo_sapiens__NP_006699

<400>  4494

Met Ala Glu Pro Gln Pro Pro Ser Gly Gly Leu Thr Asp Glu Ala Ala 
1               5                   10                  15      


Leu Ser Cys Cys Ser Asp Ala Asp Pro Ser Thr Lys Asp Phe Leu Leu 
            20                  25                  30          


Gln Gln Thr Met Leu Arg Val Lys Asp Pro Lys Lys Ser Leu Asp Phe 
        35                  40                  45              


Tyr Thr Arg Val Leu Gly Met Thr Leu Ile Gln Lys Cys Asp Phe Pro 
    50                  55                  60                  


Ile Met Lys Phe Ser Leu Tyr Phe Leu Ala Tyr Glu Asp Lys Asn Asp 
65                  70                  75                  80  


Ile Pro Lys Glu Lys Asp Glu Lys Ile Ala Trp Ala Leu Ser Arg Lys 
                85                  90                  95      


Ala Thr Leu Glu Leu Thr His Asn Trp Gly Thr Glu Asp Asp Glu Thr 
            100                 105                 110         


Gln Ser Tyr His Asn Gly Asn Ser Asp Pro Arg Gly Phe Gly His Ile 
        115                 120                 125             


Gly Ile Ala Val Pro Asp Val Tyr Ser Ala Cys Lys Arg Phe Glu Glu 
    130                 135                 140                 


Leu Gly Val Lys Phe Val Lys Lys Pro Asp Asp Gly Lys Met Lys Gly 
145                 150                 155                 160 


Leu Ala Phe Ile Gln Asp Pro Asp Gly Tyr Trp Ile Glu Ile Leu Asn 
                165                 170                 175     


Pro Asn Lys Met Ala Thr Leu Met 
            180                 


<210>  4495
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLOD4__Homo_sapiens__NP_057164

<400>  4495

Met Ala Ala Arg Arg Ala Leu His Phe Val Phe Lys Val Gly Asn Arg 
1               5                   10                  15      


Phe Gln Thr Ala Arg Phe Tyr Arg Asp Val Leu Gly Met Lys Val Leu 
            20                  25                  30          


Arg His Glu Glu Phe Glu Glu Gly Cys Lys Ala Ala Cys Asn Gly Pro 
        35                  40                  45              


Tyr Asp Gly Lys Trp Ser Lys Thr Met Val Gly Phe Gly Pro Glu Asp 
    50                  55                  60                  


Asp His Phe Val Ala Glu Leu Thr Tyr Asn Tyr Gly Val Gly Asp Tyr 
65                  70                  75                  80  


Lys Leu Gly Asn Asp Phe Met Gly Ile Thr Leu Ala Ser Ser Gln Ala 
                85                  90                  95      


Val Ser Asn Ala Arg Lys Leu Glu Trp Pro Leu Thr Glu Val Ala Glu 
            100                 105                 110         


Gly Val Phe Glu Thr Glu Ala Pro Gly Gly Tyr Lys Phe Tyr Leu Gln 
        115                 120                 125             


Asn Arg Ser Leu Pro Gln Ser Asp Pro Val Leu Lys Val Thr Leu Ala 
    130                 135                 140                 


Val Ser Asp Leu Gln Lys Ser Leu Asn Tyr Trp Cys Asn Leu Leu Gly 
145                 150                 155                 160 


Met Lys Ile Tyr Glu Lys Asp Glu Glu Lys Gln Arg Ala Leu Leu Gly 
                165                 170                 175     


Tyr Ala Asp Asn Gln Cys Lys Leu Glu Leu Gln Gly Val Lys Gly Gly 
            180                 185                 190         


Val Asp His Ala Ala Ala Phe Gly Arg Ile Ala Phe Ser Cys Pro Gln 
        195                 200                 205             


Lys Glu Leu Pro Asp Leu Glu Asp Leu Met Lys Arg Glu Asn Gln Lys 
    210                 215                 220                 


Ile Leu Thr Pro Leu Val Ser Leu Asp Thr Pro Gly Lys Ala Thr Val 
225                 230                 235                 240 


Gln Val Val Ile Leu Ala Asp Pro Asp Gly His Glu Ile Cys Phe Val 
                245                 250                 255     


Gly Asp Glu Ala Phe Arg Glu Leu Ser Lys Met Asp Pro Glu Gly Ser 
            260                 265                 270         


Lys Leu Leu Asp Asp Ala Met Ala Ala Asp Lys Ser Asp Glu Trp Phe 
        275                 280                 285             


Ala Lys His Asn Lys Pro Lys Ala Ser Gly 
    290                 295             


<210>  4496
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP1R__Homo_sapiens__NP_002053

<400>  4496

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser 
    450                 455                 460             


<210>  4497
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP2R__Homo_sapiens__NP_004237

<400>  4497

Met Lys Leu Gly Ser Ser Arg Ala Gly Pro Gly Arg Gly Ser Ala Gly 
1               5                   10                  15      


Leu Leu Pro Gly Val His Glu Leu Pro Met Gly Ile Pro Ala Pro Trp 
            20                  25                  30          


Gly Thr Ser Pro Leu Ser Phe His Arg Lys Cys Ser Leu Trp Ala Pro 
        35                  40                  45              


Gly Arg Pro Phe Leu Thr Leu Val Leu Leu Val Ser Ile Lys Gln Val 
    50                  55                  60                  


Thr Gly Ser Leu Leu Glu Glu Thr Thr Arg Lys Trp Ala Gln Tyr Lys 
65                  70                  75                  80  


Gln Ala Cys Leu Arg Asp Leu Leu Lys Glu Pro Ser Gly Ile Phe Cys 
                85                  90                  95      


Asn Gly Thr Phe Asp Gln Tyr Val Cys Trp Pro His Ser Ser Pro Gly 
            100                 105                 110         


Asn Val Ser Val Pro Cys Pro Ser Tyr Leu Pro Trp Trp Ser Glu Glu 
        115                 120                 125             


Ser Ser Gly Arg Ala Tyr Arg His Cys Leu Ala Gln Gly Thr Trp Gln 
    130                 135                 140                 


Thr Ile Glu Asn Ala Thr Asp Ile Trp Gln Asp Asp Ser Glu Cys Ser 
145                 150                 155                 160 


Glu Asn His Ser Phe Lys Gln Asn Val Asp Arg Tyr Ala Leu Leu Ser 
                165                 170                 175     


Thr Leu Gln Leu Met Tyr Thr Val Gly Tyr Ser Phe Ser Leu Ile Ser 
            180                 185                 190         


Leu Phe Leu Ala Leu Thr Leu Leu Leu Phe Leu Arg Lys Leu His Cys 
        195                 200                 205             


Thr Arg Asn Tyr Ile His Met Asn Leu Phe Ala Ser Phe Ile Leu Arg 
    210                 215                 220                 


Thr Leu Ala Val Leu Val Lys Asp Val Val Phe Tyr Asn Ser Tyr Ser 
225                 230                 235                 240 


Lys Arg Pro Asp Asn Glu Asn Gly Trp Met Ser Tyr Leu Ser Glu Met 
                245                 250                 255     


Ser Thr Ser Cys Arg Ser Val Gln Val Leu Leu His Tyr Phe Val Gly 
            260                 265                 270         


Ala Asn Tyr Leu Trp Leu Leu Val Glu Gly Leu Tyr Leu His Thr Leu 
        275                 280                 285             


Leu Glu Pro Thr Val Leu Pro Glu Arg Arg Leu Trp Pro Arg Tyr Leu 
    290                 295                 300                 


Leu Leu Gly Trp Ala Phe Pro Val Leu Phe Val Val Pro Trp Gly Phe 
305                 310                 315                 320 


Ala Arg Ala His Leu Glu Asn Thr Gly Cys Trp Thr Thr Asn Gly Asn 
                325                 330                 335     


Lys Lys Ile Trp Trp Ile Ile Arg Gly Pro Met Met Leu Cys Val Thr 
            340                 345                 350         


Val Asn Phe Phe Ile Phe Leu Lys Ile Leu Lys Leu Leu Ile Ser Lys 
        355                 360                 365             


Leu Lys Ala His Gln Met Cys Phe Arg Asp Tyr Lys Tyr Arg Leu Ala 
    370                 375                 380                 


Lys Ser Thr Leu Val Leu Ile Pro Leu Leu Gly Val His Glu Ile Leu 
385                 390                 395                 400 


Phe Ser Phe Ile Thr Asp Asp Gln Val Glu Gly Phe Ala Lys Leu Ile 
                405                 410                 415     


Arg Leu Phe Ile Gln Leu Thr Leu Ser Ser Phe His Gly Phe Leu Val 
            420                 425                 430         


Ala Leu Gln Tyr Gly Phe Ala Asn Gly Glu Val Lys Ala Glu Leu Arg 
        435                 440                 445             


Lys Tyr Trp Val Arg Phe Leu Leu Ala Arg His Ser Gly Cys Arg Ala 
    450                 455                 460                 


Cys Val Leu Gly Lys Asp Phe Arg Phe Leu Gly Lys Cys Pro Lys Lys 
465                 470                 475                 480 


Leu Ser Glu Gly Asp Gly Ala Glu Lys Leu Arg Lys Leu Gln Pro Ser 
                485                 490                 495     


Leu Asn Ser Gly Arg Leu Leu His Leu Ala Met Arg Gly Leu Gly Glu 
            500                 505                 510         


Leu Gly Ala Gln Pro Gln Gln Asp His Ala Arg Trp Pro Arg Gly Ser 
        515                 520                 525             


Ser Leu Ser Glu Cys Ser Glu Gly Asp Val Thr Met Ala Asn Thr Met 
    530                 535                 540                 


Glu Glu Ile Leu Glu Glu Ser Glu Ile 
545                 550             


<210>  4498
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRA1__Homo_sapiens__NP_000162

<400>  4498

Met Tyr Ser Phe Asn Thr Leu Arg Leu Tyr Leu Trp Glu Thr Ile Val 
1               5                   10                  15      


Phe Phe Ser Leu Ala Ala Ser Lys Glu Ala Glu Ala Ala Arg Ser Ala 
            20                  25                  30          


Pro Lys Pro Met Ser Pro Ser Asp Phe Leu Asp Lys Leu Met Gly Arg 
        35                  40                  45              


Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn Phe Lys Gly Pro Pro 
    50                  55                  60                  


Val Asn Val Ser Cys Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Ala 
65                  70                  75                  80  


Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Gln Trp 
                85                  90                  95      


Asn Asp Pro Arg Leu Ala Tyr Asn Glu Tyr Pro Asp Asp Ser Leu Asp 
            100                 105                 110         


Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys Pro Asp Leu Phe Phe 
        115                 120                 125             


Ala Asn Glu Lys Gly Ala His Phe His Glu Ile Thr Thr Asp Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Ser Arg Asn Gly Asn Val Leu Tyr Ser Ile Arg Ile 
145                 150                 155                 160 


Thr Leu Thr Leu Ala Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
                165                 170                 175     


Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe Gly Tyr Thr Met Asn 
            180                 185                 190         


Asp Leu Ile Phe Glu Trp Gln Glu Gln Gly Ala Val Gln Val Ala Asp 
        195                 200                 205             


Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys Glu Glu Lys Asp Leu Arg 
    210                 215                 220                 


Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe Thr Cys Ile Glu Ala 
225                 230                 235                 240 


Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
                245                 250                 255     


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
            260                 265                 270         


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
        275                 280                 285             


Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys 
    290                 295                 300                 


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
305                 310                 315                 320 


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
                325                 330                 335     


Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His 
            340                 345                 350         


Lys Glu Asp Glu Ala Gly Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly 
        355                 360                 365             


Met Gly Pro Ala Cys Leu Gln Ala Lys Asp Gly Ile Ser Val Lys Gly 
    370                 375                 380                 


Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser 
385                 390                 395                 400 


Pro Glu Glu Met Arg Lys Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp 
                405                 410                 415     


Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met 
            420                 425                 430         


Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp Val His Asn 
        435                 440                 445             


Gln 
    


<210>  4499
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRA2__Homo_sapiens__NP_001112357

<400>  4499

Met Asn Arg Gln Leu Val Asn Ile Leu Thr Ala Leu Phe Ala Phe Phe 
1               5                   10                  15      


Leu Glu Thr Asn His Phe Arg Thr Ala Phe Cys Lys Asp His Asp Ser 
            20                  25                  30          


Arg Ser Gly Lys Gln Pro Ser Gln Thr Leu Ser Pro Ser Asp Phe Leu 
        35                  40                  45              


Asp Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro 
    50                  55                  60                  


Asn Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn 
65                  70                  75                  80  


Ser Phe Gly Ser Val Thr Glu Thr Thr Met Asp Tyr Arg Val Asn Ile 
                85                  90                  95      


Phe Leu Arg Gln Gln Trp Asn Asp Ser Arg Leu Ala Tyr Ser Glu Tyr 
            100                 105                 110         


Pro Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp 
        115                 120                 125             


Lys Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Asp 
    130                 135                 140                 


Val Thr Thr Asp Asn Lys Leu Leu Arg Ile Ser Lys Asn Gly Lys Val 
145                 150                 155                 160 


Leu Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu 
                165                 170                 175     


Lys Asn Phe Pro Met Asp Val Gln Thr Cys Thr Met Gln Leu Glu Ser 
            180                 185                 190         


Phe Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Leu Ser Asp Gly 
        195                 200                 205             


Pro Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys 
    210                 215                 220                 


Glu Glu Lys Glu Leu Gly Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys 
225                 230                 235                 240 


Phe Thr Cys Ile Glu Val Lys Phe His Leu Glu Arg Gln Met Gly Tyr 
                245                 250                 255     


Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser 
            260                 265                 270         


Trp Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala 
        275                 280                 285             


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser 
    290                 295                 300                 


Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp 
305                 310                 315                 320 


Met Ala Val Cys Leu Leu Phe Val Phe Ala Ala Leu Leu Glu Tyr Ala 
                325                 330                 335     


Ala Val Asn Phe Val Ser Arg Gln His Lys Glu Phe Leu Arg Leu Arg 
            340                 345                 350         


Arg Arg Gln Lys Arg Gln Asn Lys Glu Glu Asp Val Thr Arg Glu Ser 
        355                 360                 365             


Arg Phe Asn Phe Ser Gly Tyr Gly Met Gly His Cys Leu Gln Val Lys 
    370                 375                 380                 


Asp Gly Thr Ala Val Lys Ala Thr Pro Ala Asn Pro Leu Pro Gln Pro 
385                 390                 395                 400 


Pro Lys Asp Gly Asp Ala Ile Lys Lys Lys Phe Val Asp Arg Ala Lys 
                405                 410                 415     


Arg Ile Asp Thr Ile Ser Arg Ala Ala Phe Pro Leu Ala Phe Leu Ile 
            420                 425                 430         


Phe Asn Ile Phe Tyr Trp Ile Thr Tyr Lys Ile Ile Arg His Glu Asp 
        435                 440                 445             


Val His Lys Lys 
    450         


<210>  4500
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRA3__Homo_sapiens__NP_001036008

<400>  4500

Met Ala His Val Arg His Phe Arg Thr Leu Val Ser Gly Phe Tyr Phe 
1               5                   10                  15      


Trp Glu Ala Ala Leu Leu Leu Ser Leu Val Ala Thr Lys Glu Thr Asp 
            20                  25                  30          


Ser Ala Arg Ser Arg Ser Ala Pro Met Ser Pro Ser Asp Phe Leu Asp 
        35                  40                  45              


Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn 
    50                  55                  60                  


Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn Ser 
65                  70                  75                  80  


Phe Gly Ser Ile Ala Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe 
                85                  90                  95      


Leu Arg Gln Lys Trp Asn Asp Pro Arg Leu Ala Tyr Ser Glu Tyr Pro 
            100                 105                 110         


Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys 
        115                 120                 125             


Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Glu Val 
    130                 135                 140                 


Thr Thr Asp Asn Lys Leu Leu Arg Ile Phe Lys Asn Gly Asn Val Leu 
145                 150                 155                 160 


Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu Lys 
                165                 170                 175     


Asn Phe Pro Met Asp Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe 
            180                 185                 190         


Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Gln Asp Glu Ala Pro 
        195                 200                 205             


Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Leu Leu Lys Glu 
    210                 215                 220                 


Glu Lys Asp Leu Arg Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe 
225                 230                 235                 240 


Thr Cys Ile Glu Val Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr 
                245                 250                 255     


Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg 
    290                 295                 300                 


Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met 
305                 310                 315                 320 


Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala 
                325                 330                 335     


Val Asn Phe Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg 
            340                 345                 350         


Lys Arg Lys Asn Lys Asp Asp Glu Val Arg Glu Ser Arg Phe Ser Phe 
        355                 360                 365             


Thr Ala Tyr Gly Met Gly Pro Cys Leu Gln Ala Lys Asp Gly Met Thr 
    370                 375                 380                 


Pro Lys Gly Pro Asn His Pro Val Gln Val Met Pro Lys Ser Pro Asp 
385                 390                 395                 400 


Glu Met Arg Lys Val Phe Ile Asp Arg Ala Lys Lys Ile Asp Thr Ile 
                405                 410                 415     


Ser Arg Ala Cys Phe Pro Leu Ala Phe Leu Ile Phe Asn Ile Phe Tyr 
            420                 425                 430         


Trp Val Ile Tyr Lys Ile Leu Arg His Glu Asp Ile His Gln Gln Gln 
        435                 440                 445             


Asp 
    


<210>  4501
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRB__Homo_sapiens__NP_001159532

<400>  4501

Met Lys Phe Leu Leu Thr Thr Ala Phe Leu Ile Leu Ile Ser Leu Trp 
1               5                   10                  15      


Val Glu Glu Ala Tyr Ser Lys Glu Lys Ser Ser Lys Lys Gly Lys Gly 
            20                  25                  30          


Lys Lys Lys Gln Tyr Leu Cys Pro Ser Gln Gln Ser Ala Glu Asp Leu 
        35                  40                  45              


Ala Arg Val Pro Ala Asn Ser Thr Ser Asn Ile Leu Asn Arg Leu Leu 
    50                  55                  60                  


Val Ser Tyr Asp Pro Arg Ile Arg Pro Asn Phe Lys Gly Ile Pro Val 
65                  70                  75                  80  


Asp Val Val Val Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Gln Glu 
                85                  90                  95      


Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Lys Trp Asn 
            100                 105                 110         


Asp Pro Arg Leu Lys Leu Pro Ser Asp Phe Arg Gly Ser Asp Ala Leu 
        115                 120                 125             


Thr Val Asp Pro Thr Met Tyr Lys Cys Leu Trp Lys Pro Asp Leu Phe 
    130                 135                 140                 


Phe Ala Asn Glu Lys Ser Ala Asn Phe His Asp Val Thr Gln Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Phe Ile Phe Arg Asp Gly Asp Val Leu Val Ser Met Arg 
                165                 170                 175     


Leu Ser Ile Thr Leu Ser Cys Pro Leu Asp Leu Thr Leu Phe Pro Met 
            180                 185                 190         


Asp Thr Gln Arg Cys Lys Met Gln Leu Glu Ser Phe Gly Tyr Thr Thr 
        195                 200                 205             


Asp Asp Leu Arg Phe Ile Trp Gln Ser Gly Asp Pro Val Gln Leu Glu 
    210                 215                 220                 


Lys Ile Ala Leu Pro Gln Phe Asp Ile Lys Lys Glu Asp Ile Glu Tyr 
225                 230                 235                 240 


Gly Asn Cys Thr Lys Tyr Tyr Lys Gly Thr Gly Tyr Tyr Thr Cys Val 
                245                 250                 255     


Glu Val Ile Phe Thr Leu Arg Arg Gln Val Gly Phe Tyr Met Met Gly 
            260                 265                 270         


Val Tyr Ala Pro Thr Leu Leu Ile Val Val Leu Ser Trp Leu Ser Phe 
        275                 280                 285             


Trp Ile Asn Pro Asp Ala Ser Ala Ala Arg Val Pro Leu Gly Ile Phe 
    290                 295                 300                 


Ser Val Leu Ser Leu Ala Ser Glu Cys Thr Thr Leu Ala Ala Glu Leu 
305                 310                 315                 320 


Pro Lys Val Ser Tyr Val Lys Ala Leu Asp Val Trp Leu Ile Ala Cys 
                325                 330                 335     


Leu Leu Phe Gly Phe Ala Ser Leu Val Glu Tyr Ala Val Val Gln Val 
            340                 345                 350         


Met Leu Asn Asn Pro Lys Arg Val Glu Ala Glu Lys Ala Arg Ile Ala 
        355                 360                 365             


Lys Ala Glu Gln Ala Asp Gly Lys Gly Gly Asn Val Ala Lys Lys Asn 
    370                 375                 380                 


Thr Val Asn Gly Thr Gly Thr Pro Val His Ile Ser Thr Leu Gln Val 
385                 390                 395                 400 


Gly Glu Thr Arg Cys Lys Lys Val Cys Thr Ser Lys Ser Asp Leu Arg 
                405                 410                 415     


Ser Asn Asp Phe Ser Ile Val Gly Ser Leu Pro Arg Asp Phe Glu Leu 
            420                 425                 430         


Ser Asn Tyr Asp Cys Tyr Gly Lys Pro Ile Glu Val Asn Asn Gly Leu 
        435                 440                 445             


Gly Lys Ser Gln Ala Lys Asn Asn Lys Lys Pro Pro Pro Ala Lys Pro 
    450                 455                 460                 


Val Ile Pro Thr Ala Ala Lys Arg Ile Asp Leu Tyr Ala Arg Ala Leu 
465                 470                 475                 480 


Phe Pro Phe Cys Phe Leu Phe Phe Asn Val Ile Tyr Trp Ser Ile Tyr 
                485                 490                 495     


Leu 
    


<210>  4502
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRX2__Homo_sapiens__NP_057150

<400>  4502

Met Asn Pro Arg Asp Lys Gln Val Ser Arg Phe Ser Pro Leu Lys Asp 
1               5                   10                  15      


Val Tyr Thr Trp Val Ala Leu Ala Gly Ile Gln Arg Ser Gly Ser Pro 
            20                  25                  30          


Gly Arg Thr Arg Ser Ala Ala Arg Arg Met Glu Ser Asn Thr Ser Ser 
        35                  40                  45              


Ser Leu Glu Asn Leu Ala Thr Ala Pro Val Asn Gln Ile Gln Glu Thr 
    50                  55                  60                  


Ile Ser Asp Asn Cys Val Val Ile Phe Ser Lys Thr Ser Cys Ser Tyr 
65                  70                  75                  80  


Cys Thr Met Ala Lys Lys Leu Phe His Asp Met Asn Val Asn Tyr Lys 
                85                  90                  95      


Val Val Glu Leu Asp Leu Leu Glu Tyr Gly Asn Gln Phe Gln Asp Ala 
            100                 105                 110         


Leu Tyr Lys Met Thr Gly Glu Arg Thr Val Pro Arg Ile Phe Val Asn 
        115                 120                 125             


Gly Thr Phe Ile Gly Gly Ala Thr Asp Thr His Arg Leu His Lys Glu 
    130                 135                 140                 


Gly Lys Leu Leu Pro Leu Val His Gln Cys Tyr Leu Lys Lys Ser Lys 
145                 150                 155                 160 


Arg Lys Glu Phe Gln 
                165 


<210>  4503
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRX3__Homo_sapiens__NP_006532

<400>  4503

Met Ala Ala Gly Ala Ala Glu Ala Ala Val Ala Ala Val Glu Glu Val 
1               5                   10                  15      


Gly Ser Ala Gly Gln Phe Glu Glu Leu Leu Arg Leu Lys Ala Lys Ser 
            20                  25                  30          


Leu Leu Val Val His Phe Trp Ala Pro Trp Ala Pro Gln Cys Ala Gln 
        35                  40                  45              


Met Asn Glu Val Met Ala Glu Leu Ala Lys Glu Leu Pro Gln Val Ser 
    50                  55                  60                  


Phe Val Lys Leu Glu Ala Glu Gly Val Pro Glu Val Ser Glu Lys Tyr 
65                  70                  75                  80  


Glu Ile Ser Ser Val Pro Thr Phe Leu Phe Phe Lys Asn Ser Gln Lys 
                85                  90                  95      


Ile Asp Arg Leu Asp Gly Ala His Ala Pro Glu Leu Thr Lys Lys Val 
            100                 105                 110         


Gln Arg His Ala Ser Ser Gly Ser Phe Leu Pro Ser Ala Asn Glu His 
        115                 120                 125             


Leu Lys Glu Asp Leu Asn Leu Arg Leu Lys Lys Leu Thr His Ala Ala 
    130                 135                 140                 


Pro Cys Met Leu Phe Met Lys Gly Thr Pro Gln Glu Pro Arg Cys Gly 
145                 150                 155                 160 


Phe Ser Lys Gln Met Val Glu Ile Leu His Lys His Asn Ile Gln Phe 
                165                 170                 175     


Ser Ser Phe Asp Ile Phe Ser Asp Glu Glu Val Arg Gln Gly Leu Lys 
            180                 185                 190         


Ala Tyr Ser Ser Trp Pro Thr Tyr Pro Gln Leu Tyr Val Ser Gly Glu 
        195                 200                 205             


Leu Ile Gly Gly Leu Asp Ile Ile Lys Glu Leu Glu Ala Ser Glu Glu 
    210                 215                 220                 


Leu Asp Thr Ile Cys Pro Lys Ala Pro Lys Leu Glu Glu Arg Leu Lys 
225                 230                 235                 240 


Val Leu Thr Asn Lys Ala Ser Val Met Leu Phe Met Lys Gly Asn Lys 
                245                 250                 255     


Gln Glu Ala Lys Cys Gly Phe Ser Lys Gln Ile Leu Glu Ile Leu Asn 
            260                 265                 270         


Ser Thr Gly Val Glu Tyr Glu Thr Phe Asp Ile Leu Glu Asp Glu Glu 
        275                 280                 285             


Val Arg Gln Gly Leu Lys Ala Tyr Ser Asn Trp Pro Thr Tyr Pro Gln 
    290                 295                 300                 


Leu Tyr Val Lys Gly Glu Leu Val Gly Gly Leu Asp Ile Val Lys Glu 
305                 310                 315                 320 


Leu Lys Glu Asn Gly Glu Leu Leu Pro Ile Leu Arg Gly Glu Asn 
                325                 330                 335 


<210>  4504
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRX5__Homo_sapiens__NP_057501

<400>  4504

Met Ser Gly Ser Leu Gly Arg Ala Ala Ala Ala Leu Leu Arg Trp Gly 
1               5                   10                  15      


Arg Gly Ala Gly Gly Gly Gly Leu Trp Gly Pro Gly Val Arg Ala Ala 
            20                  25                  30          


Gly Ser Gly Ala Gly Gly Gly Gly Ser Ala Glu Gln Leu Asp Ala Leu 
        35                  40                  45              


Val Lys Lys Asp Lys Val Val Val Phe Leu Lys Gly Thr Pro Glu Gln 
    50                  55                  60                  


Pro Gln Cys Gly Phe Ser Asn Ala Val Val Gln Ile Leu Arg Leu His 
65                  70                  75                  80  


Gly Val Arg Asp Tyr Ala Ala Tyr Asn Val Leu Asp Asp Pro Glu Leu 
                85                  90                  95      


Arg Gln Gly Ile Lys Asp Tyr Ser Asn Trp Pro Thr Ile Pro Gln Val 
            100                 105                 110         


Tyr Leu Asn Gly Glu Phe Val Gly Gly Cys Asp Ile Leu Leu Gln Met 
        115                 120                 125             


His Gln Asn Gly Asp Leu Val Glu Glu Leu Lys Lys Leu Gly Ile His 
    130                 135                 140                 


Ser Ala Leu Leu Asp Glu Lys Lys Asp Gln Asp Ser Lys 
145                 150                 155         


<210>  4505
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRX__Homo_sapiens__NP_001230588

<400>  4505

Met Ala Gln Glu Phe Val Asn Cys Lys Ile Gln Pro Gly Lys Val Val 
1               5                   10                  15      


Val Phe Ile Lys Pro Thr Cys Pro Tyr Cys Arg Arg Ala Gln Glu Ile 
            20                  25                  30          


Leu Ser Gln Leu Pro Ile Lys Gln Gly Leu Leu Glu Phe Val Asp Ile 
        35                  40                  45              


Thr Ala Thr Asn His Thr Asn Glu Ile Gln Asp Tyr Leu Gln Gln Leu 
    50                  55                  60                  


Thr Gly Ala Arg Thr Val Pro Arg Val Phe Ile Gly Lys Asp Cys Ile 
65                  70                  75                  80  


Gly Gly Cys Ser Asp Leu Val Ser Leu Gln Gln Ser Gly Glu Leu Leu 
                85                  90                  95      


Thr Arg Leu Lys Gln Ile Gly Ala Leu Gln 
            100                 105     


<210>  4506
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLS2__Homo_sapiens__NP_037399

<400>  4506

Met Arg Ser Met Lys Ala Leu Gln Lys Ala Leu Ser Arg Ala Gly Ser 
1               5                   10                  15      


His Cys Gly Arg Gly Gly Trp Gly His Pro Ser Arg Ser Pro Leu Leu 
            20                  25                  30          


Gly Gly Gly Val Arg His His Leu Ser Glu Ala Ala Ala Gln Gly Arg 
        35                  40                  45              


Glu Thr Pro His Ser His Gln Pro Gln His Gln Asp His Asp Ser Ser 
    50                  55                  60                  


Glu Ser Gly Met Leu Ser Arg Leu Gly Asp Leu Leu Phe Tyr Thr Ile 
65                  70                  75                  80  


Ala Glu Gly Gln Glu Arg Ile Pro Ile His Lys Phe Thr Thr Ala Leu 
                85                  90                  95      


Lys Ala Thr Gly Leu Gln Thr Ser Asp Pro Arg Leu Arg Asp Cys Met 
            100                 105                 110         


Ser Glu Met His Arg Val Val Gln Glu Ser Ser Ser Gly Gly Leu Leu 
        115                 120                 125             


Asp Arg Asp Leu Phe Arg Lys Cys Val Ser Ser Asn Ile Val Leu Leu 
    130                 135                 140                 


Thr Gln Ala Phe Arg Lys Lys Phe Val Ile Pro Asp Phe Glu Glu Phe 
145                 150                 155                 160 


Thr Gly His Val Asp Arg Ile Phe Glu Asp Val Lys Glu Leu Thr Gly 
                165                 170                 175     


Gly Lys Val Ala Ala Tyr Ile Pro Gln Leu Ala Lys Ser Asn Pro Asp 
            180                 185                 190         


Leu Trp Gly Val Ser Leu Cys Thr Val Asp Gly Gln Arg His Ser Val 
        195                 200                 205             


Gly His Thr Lys Ile Pro Phe Cys Leu Gln Ser Cys Val Lys Pro Leu 
    210                 215                 220                 


Thr Tyr Ala Ile Ser Ile Ser Thr Leu Gly Thr Asp Tyr Val His Lys 
225                 230                 235                 240 


Phe Val Gly Lys Glu Pro Ser Gly Leu Arg Tyr Asn Lys Leu Ser Leu 
                245                 250                 255     


Asn Glu Glu Gly Ile Pro His Asn Pro Met Val Asn Ala Gly Ala Ile 
            260                 265                 270         


Val Val Ser Ser Leu Ile Lys Met Asp Cys Asn Lys Ala Glu Lys Phe 
        275                 280                 285             


Asp Phe Val Leu Gln Tyr Leu Asn Lys Met Ala Gly Asn Glu Tyr Met 
    290                 295                 300                 


Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Lys Glu Thr Gly Asp Arg 
305                 310                 315                 320 


Asn Tyr Ala Ile Gly Tyr Tyr Leu Lys Glu Lys Lys Cys Phe Pro Lys 
                325                 330                 335     


Gly Val Asp Met Met Ala Ala Leu Asp Leu Tyr Phe Gln Leu Cys Ser 
            340                 345                 350         


Val Glu Val Thr Cys Glu Ser Gly Ser Val Met Ala Ala Thr Leu Ala 
        355                 360                 365             


Asn Gly Gly Ile Cys Pro Ile Thr Gly Glu Ser Val Leu Ser Ala Glu 
    370                 375                 380                 


Ala Val Arg Asn Thr Leu Ser Leu Met His Ser Cys Gly Met Tyr Asp 
385                 390                 395                 400 


Phe Ser Gly Gln Phe Ala Phe His Val Gly Leu Pro Ala Lys Ser Ala 
                405                 410                 415     


Val Ser Gly Ala Ile Leu Leu Val Val Pro Asn Val Met Gly Met Met 
            420                 425                 430         


Cys Leu Ser Pro Pro Leu Asp Lys Leu Gly Asn Ser His Arg Gly Thr 
        435                 440                 445             


Ser Phe Cys Gln Lys Leu Val Ser Leu Phe Asn Phe His Asn Tyr Asp 
    450                 455                 460                 


Asn Leu Arg His Cys Ala Arg Lys Leu Asp Pro Arg Arg Glu Gly Ala 
465                 470                 475                 480 


Glu Ile Arg Asn Lys Thr Val Val Asn Leu Leu Phe Ala Ala Tyr Ser 
                485                 490                 495     


Gly Asp Val Ser Ala Leu Arg Arg Phe Ala Leu Ser Ala Met Asp Met 
            500                 505                 510         


Glu Gln Lys Asp Tyr Asp Ser Arg Thr Ala Leu His Val Ala Ala Ala 
        515                 520                 525             


Glu Gly His Ile Glu Val Val Lys Phe Leu Ile Glu Ala Cys Lys Val 
    530                 535                 540                 


Asn Pro Phe Ala Lys Asp Arg Trp Gly Asn Ile Pro Leu Asp Asp Ala 
545                 550                 555                 560 


Val Gln Phe Asn His Leu Glu Val Val Lys Leu Leu Gln Asp Tyr Gln 
                565                 570                 575     


Asp Ser Tyr Thr Leu Ser Glu Thr Gln Ala Glu Ala Ala Ala Glu Ala 
            580                 585                 590         


Leu Ser Lys Glu Asn Leu Glu Ser Met Val 
        595                 600         


<210>  4507
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLS__Homo_sapiens__NP_001243239

<400>  4507

Met Met Arg Leu Arg Gly Ser Gly Met Leu Arg Asp Leu Leu Leu Arg 
1               5                   10                  15      


Ser Pro Ala Gly Val Ser Ala Thr Leu Arg Arg Ala Gln Pro Leu Val 
            20                  25                  30          


Thr Leu Cys Arg Arg Pro Arg Gly Gly Gly Arg Pro Ala Ala Gly Pro 
        35                  40                  45              


Ala Ala Ala Ala Arg Leu His Pro Trp Trp Gly Gly Gly Gly Trp Pro 
    50                  55                  60                  


Ala Glu Pro Leu Ala Arg Gly Leu Ser Ser Ser Pro Ser Glu Ile Leu 
65                  70                  75                  80  


Gln Glu Leu Gly Lys Gly Ser Thr His Pro Gln Pro Gly Val Ser Pro 
                85                  90                  95      


Pro Ala Ala Pro Ala Ala Pro Gly Pro Lys Asp Gly Pro Gly Glu Thr 
            100                 105                 110         


Asp Ala Phe Gly Asn Ser Glu Gly Lys Glu Leu Val Ala Ser Gly Glu 
        115                 120                 125             


Asn Lys Ile Lys Gln Gly Leu Leu Pro Ser Leu Glu Asp Leu Leu Phe 
    130                 135                 140                 


Tyr Thr Ile Ala Glu Gly Gln Glu Lys Ile Pro Val His Lys Phe Ile 
145                 150                 155                 160 


Thr Ala Leu Lys Ser Thr Gly Leu Arg Thr Ser Asp Pro Arg Leu Lys 
                165                 170                 175     


Glu Cys Met Asp Met Leu Arg Leu Thr Leu Gln Thr Thr Ser Asp Gly 
            180                 185                 190         


Val Met Leu Asp Lys Asp Leu Phe Lys Lys Cys Val Gln Ser Asn Ile 
        195                 200                 205             


Val Leu Leu Thr Gln Ala Phe Arg Arg Lys Phe Val Ile Pro Asp Phe 
    210                 215                 220                 


Met Ser Phe Thr Ser His Ile Asp Glu Leu Tyr Glu Ser Ala Lys Lys 
225                 230                 235                 240 


Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro Gln Leu Ala Lys Phe 
                245                 250                 255     


Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr Val Asp Gly Gln Arg 
            260                 265                 270         


His Ser Thr Gly Asp Thr Lys Val Pro Phe Cys Leu Gln Ser Cys Val 
        275                 280                 285             


Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp Leu Gly Thr Glu Tyr 
    290                 295                 300                 


Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly Leu Arg Phe Asn Lys 
305                 310                 315                 320 


Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn Pro Met Val Asn Ala 
                325                 330                 335     


Gly Ala Ile Val Val Thr Ser Leu Ile Lys Gln Gly Val Asn Asn Ala 
            340                 345                 350         


Glu Lys Phe Asp Tyr Val Met Gln Phe Leu Asn Lys Met Ala Gly Asn 
        355                 360                 365             


Glu Tyr Val Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Arg Glu Ser 
    370                 375                 380                 


Gly Asp Arg Asn Phe Ala Ile Gly Tyr Tyr Leu Lys Glu Lys Lys Cys 
385                 390                 395                 400 


Phe Pro Glu Gly Thr Asp Met Val Gly Ile Leu Asp Phe Tyr Phe Gln 
                405                 410                 415     


Leu Cys Ser Ile Glu Val Thr Cys Glu Ser Ala Ser Val Met Ala Ala 
            420                 425                 430         


Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu Arg Val Leu 
        435                 440                 445             


Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His Ser Cys Gly 
    450                 455                 460                 


Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly Leu Pro Ala 
465                 470                 475                 480 


Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro Asn Val Met 
                485                 490                 495     


Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser Val 
            500                 505                 510         


Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe His 
        515                 520                 525             


Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg Arg 
    530                 535                 540                 


Glu Gly Gly Asp Gln Arg His Ser Phe Gly Pro Leu Asp Tyr Glu Ser 
545                 550                 555                 560 


Leu Gln Gln Glu Leu Ala Leu Lys Glu Thr Val Trp Lys Lys Val Ser 
                565                 570                 575     


Pro Glu Ser Asn Glu Asp Ile Ser Thr Thr Val Val Tyr Arg Met Glu 
            580                 585                 590         


Ser Leu Gly Glu Lys Ser 
        595             


<210>  4508
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLT1D1__Homo_sapiens__NP_653270

<400>  4508

Met Arg Leu Leu Phe Leu Ala Val Leu Arg Pro His Thr Gly Asn Ala 
1               5                   10                  15      


Val Thr Ala Gln Arg Val Arg Ala His Leu Glu Ala Ala Gly His Val 
            20                  25                  30          


Cys Val Leu Lys Asp Ala Phe Asp Phe Glu Ser Arg Ser Glu Ile Ala 
        35                  40                  45              


Asn Leu Ile Leu Ala Glu Asn Cys Glu Ala Ala Leu Ala Leu His Leu 
    50                  55                  60                  


Tyr Arg Gly Gly Arg Leu Leu Gln Gly His Arg Ile Pro Phe Gly Val 
65                  70                  75                  80  


Ile Phe Gly Gly Thr Asp Val Asn Glu Asp Ala Asn Gln Ala Glu Lys 
                85                  90                  95      


Asn Thr Val Met Gly Arg Val Leu Glu Glu Ala Arg Phe Ala Val Ala 
            100                 105                 110         


Phe Thr Glu Ser Met Lys Glu Met Ala Gln Ala Gln Trp Val Asp Pro 
        115                 120                 125             


Val Phe Thr Arg Glu Val Lys Ala Lys Val Lys Arg Ala Ala Gly Val 
    130                 135                 140                 


Arg Leu Ile Gly Glu Met Pro Gln Glu Asp Leu His Ala Val Val Lys 
145                 150                 155                 160 


Asn Cys Phe Ala Val Val Asn Ser Ser Val Ser Glu Gly Met Ser Ala 
                165                 170                 175     


Ala Ile Leu Glu Ala Met Asp Leu Glu Val Pro Val Leu Ala Arg Asn 
            180                 185                 190         


Ile Pro Gly Asn Ala Ala Val Val Lys His Glu Val Thr Gly Leu Leu 
        195                 200                 205             


Phe Ser Asn Pro Gln Glu Phe Val His Leu Ala Lys Arg Leu Val Ser 
    210                 215                 220                 


Asp Pro Ala Leu Glu Lys Glu Ile Val Val Asn Gly Arg Glu Tyr Val 
225                 230                 235                 240 


Arg Met Tyr His Ser Trp Gln Val Glu Arg Asp Thr Tyr Gln Gln Leu 
                245                 250                 255     


Ile Arg Lys Leu Glu Gly Ser Thr Glu Asp 
            260                 265     


<210>  4509
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLT6D1__Homo_sapiens__XP_011516939

<400>  4509

Met Asn Ser Lys Arg Met Leu Leu Leu Val Leu Phe Ala Phe Ser Leu 
1               5                   10                  15      


Met Leu Val Glu Arg Tyr Phe Arg Asn His Gln Val Glu Glu Leu Arg 
            20                  25                  30          


Leu Ser Asp Trp Phe His Pro Arg Lys Arg Pro Asp Val Ile Thr Lys 
        35                  40                  45              


Thr Asp Trp Leu Ala Pro Val Leu Trp Glu Gly Thr Phe Asp Arg Arg 
    50                  55                  60                  


Val Leu Glu Lys His Tyr Arg Arg Arg Asn Ile Thr Val Gly Leu Ala 
65                  70                  75                  80  


Val Phe Ala Thr Gly Arg Phe Ala Glu Glu Tyr Leu Arg Pro Phe Leu 
                85                  90                  95      


His Ser Ala Asn Lys His Phe Met Thr Gly Tyr Arg Val Ile Phe Tyr 
            100                 105                 110         


Ile Met Val Asp Ala Phe Phe Lys Leu Pro Asp Ile Glu Pro Ser Pro 
        115                 120                 125             


Leu Arg Thr Phe Lys Ala Phe Lys Val Gly Thr Glu Arg Trp Trp Leu 
    130                 135                 140                 


Asp Gly Pro Leu Val His Val Lys Ser Leu Gly Glu His Ile Ala Ser 
145                 150                 155                 160 


His Ile Gln Asp Glu Val Asp Phe Leu Phe Ser Met Ala Ala Asn Gln 
                165                 170                 175     


Val Phe Gln Asn Glu Phe Gly Val Glu Thr Leu Gly Pro Leu Val Ala 
            180                 185                 190         


Gln Leu His Ala Trp Trp Tyr Phe Arg Asn Thr Lys Asn Phe Pro Tyr 
        195                 200                 205             


Glu Arg Arg Pro Thr Ser Ala Ala Cys Ile Pro Phe Gly Gln Gly Asp 
    210                 215                 220                 


Phe Tyr Tyr Gly Asn Leu Met Val Gly Gly Thr Pro His Asn Ile Leu 
225                 230                 235                 240 


Asp Phe Ile Lys Glu Tyr Leu Asn Gly Val Ile His Asp Ile Lys Asn 
                245                 250                 255     


Gly Leu Asn Ser Thr Tyr Glu Lys His Leu Asn Lys Tyr Phe Tyr Leu 
            260                 265                 270         


Asn Lys Pro Thr 
        275     


<210>  4510
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLT8D1__Homo_sapiens__NP_001010983

<400>  4510

Met Ser Phe Arg Lys Val Asn Ile Ile Ile Leu Val Leu Ala Val Ala 
1               5                   10                  15      


Leu Phe Leu Leu Val Leu His His Asn Phe Leu Ser Leu Ser Ser Leu 
            20                  25                  30          


Leu Arg Asn Glu Val Thr Asp Ser Gly Ile Val Gly Pro Gln Pro Ile 
        35                  40                  45              


Asp Phe Val Pro Asn Ala Leu Arg His Ala Val Asp Gly Arg Gln Glu 
    50                  55                  60                  


Glu Ile Pro Val Val Ile Ala Ala Ser Glu Asp Arg Leu Gly Gly Ala 
65                  70                  75                  80  


Ile Ala Ala Ile Asn Ser Ile Gln His Asn Thr Arg Ser Asn Val Ile 
                85                  90                  95      


Phe Tyr Ile Val Thr Leu Asn Asn Thr Ala Asp His Leu Arg Ser Trp 
            100                 105                 110         


Leu Asn Ser Asp Ser Leu Lys Ser Ile Arg Tyr Lys Ile Val Asn Phe 
        115                 120                 125             


Asp Pro Lys Leu Leu Glu Gly Lys Val Lys Glu Asp Pro Asp Gln Gly 
    130                 135                 140                 


Glu Ser Met Lys Pro Leu Thr Phe Ala Arg Phe Tyr Leu Pro Ile Leu 
145                 150                 155                 160 


Val Pro Ser Ala Lys Lys Ala Ile Tyr Met Asp Asp Asp Val Ile Val 
                165                 170                 175     


Gln Gly Asp Ile Leu Ala Leu Tyr Asn Thr Ala Leu Lys Pro Gly His 
            180                 185                 190         


Ala Ala Ala Phe Ser Glu Asp Cys Asp Ser Ala Ser Thr Lys Val Val 
        195                 200                 205             


Ile Arg Gly Ala Gly Asn Gln Tyr Asn Tyr Ile Gly Tyr Leu Asp Tyr 
    210                 215                 220                 


Lys Lys Glu Arg Ile Arg Lys Leu Ser Met Lys Ala Ser Thr Cys Ser 
225                 230                 235                 240 


Phe Asn Pro Gly Val Phe Val Ala Asn Leu Thr Glu Trp Lys Arg Gln 
                245                 250                 255     


Asn Ile Thr Asn Gln Leu Glu Lys Trp Met Lys Leu Asn Val Glu Glu 
            260                 265                 270         


Gly Leu Tyr Ser Arg Thr Leu Ala Gly Ser Ile Thr Thr Pro Pro Leu 
        275                 280                 285             


Leu Ile Val Phe Tyr Gln Gln His Ser Thr Ile Asp Pro Met Trp Asn 
    290                 295                 300                 


Val Arg His Leu Gly Ser Ser Ala Gly Lys Arg Tyr Ser Pro Gln Phe 
305                 310                 315                 320 


Val Lys Ala Ala Lys Leu Leu His Trp Asn Gly His Leu Lys Pro Trp 
                325                 330                 335     


Gly Arg Thr Ala Ser Tyr Thr Asp Val Trp Glu Lys Trp Tyr Ile Pro 
            340                 345                 350         


Asp Pro Thr Gly Lys Phe Asn Leu Ile Arg Arg Tyr Thr Glu Ile Ser 
        355                 360                 365             


Asn Ile Lys 
    370     


<210>  4511
<211>  1560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLTSCR1__Homo_sapiens__XP_005258890

<400>  4511

Met Asp Asp Glu Asp Gly Arg Cys Leu Leu Asp Val Ile Cys Asp Pro 
1               5                   10                  15      


Gln Ala Leu Asn Asp Phe Leu His Gly Ser Glu Lys Leu Asp Ser Asp 
            20                  25                  30          


Asp Leu Leu Asp Asn Pro Gly Glu Ala Gln Ser Ala Phe Tyr Glu Gly 
        35                  40                  45              


Pro Gly Leu His Val Gln Glu Ala Ser Gly Asn His Leu Asn Pro Glu 
    50                  55                  60                  


Pro Asn Gln Pro Ala Pro Ser Val Asp Leu Asp Phe Leu Glu Asp Asp 
65                  70                  75                  80  


Ile Leu Gly Ser Pro Ala Thr Gly Gly Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Ala Asp Gln Pro Cys Asp Ile Leu Gln Gln Ser Leu Gln Glu Ala Asn 
            100                 105                 110         


Ile Thr Glu Gln Thr Leu Glu Ala Glu Ala Glu Leu Asp Leu Gly Pro 
        115                 120                 125             


Phe Gln Leu Pro Thr Leu Gln Pro Ala Asp Gly Gly Ala Gly Pro Thr 
    130                 135                 140                 


Gly Ala Gly Gly Ala Ala Ala Val Ala Ala Gly Pro Gln Ala Leu Phe 
145                 150                 155                 160 


Pro Gly Ser Thr Asp Leu Leu Gly Leu Gln Gly Pro Pro Thr Val Leu 
                165                 170                 175     


Thr His Gln Ala Leu Val Pro Pro Gln Asp Val Val Asn Lys Ala Leu 
            180                 185                 190         


Ser Val Gln Pro Phe Leu Gln Pro Val Gly Leu Gly Asn Val Thr Leu 
        195                 200                 205             


Gln Pro Ile Pro Gly Leu Gln Gly Leu Pro Asn Gly Ser Pro Gly Gly 
    210                 215                 220                 


Ala Thr Ala Ala Thr Leu Gly Leu Ala Pro Ile Gln Val Val Gly Gln 
225                 230                 235                 240 


Pro Val Met Ala Leu Asn Thr Pro Thr Ser Gln Leu Leu Ala Lys Gln 
                245                 250                 255     


Val Pro Val Ser Gly Tyr Leu Ala Ser Ala Ala Gly Pro Ser Glu Pro 
            260                 265                 270         


Val Thr Leu Ala Ser Ala Gly Val Ser Pro Gln Gly Ala Gly Leu Val 
        275                 280                 285             


Ile Gln Lys Asn Leu Ser Ala Ala Val Ala Thr Thr Leu Asn Gly Asn 
    290                 295                 300                 


Ser Val Phe Gly Gly Ala Gly Ala Ala Ser Ala Pro Thr Gly Thr Pro 
305                 310                 315                 320 


Ser Gly Gln Pro Leu Ala Val Ala Pro Gly Leu Gly Ser Ser Pro Leu 
                325                 330                 335     


Val Pro Ala Pro Asn Val Ile Leu His Arg Thr Pro Thr Pro Ile Gln 
            340                 345                 350         


Pro Lys Pro Ala Gly Val Leu Pro Pro Lys Leu Tyr Gln Leu Thr Pro 
        355                 360                 365             


Lys Pro Phe Ala Pro Ala Gly Ala Thr Leu Thr Ile Gln Gly Glu Pro 
    370                 375                 380                 


Gly Ala Leu Pro Gln Gln Pro Lys Ala Pro Gln Asn Leu Thr Phe Met 
385                 390                 395                 400 


Ala Ala Gly Lys Ala Gly Gln Asn Val Val Leu Ser Gly Phe Pro Ala 
                405                 410                 415     


Pro Ala Leu Gln Ala Asn Val Phe Lys Gln Pro Pro Ala Thr Thr Thr 
            420                 425                 430         


Gly Ala Ala Pro Pro Gln Pro Pro Gly Ala Leu Ser Lys Pro Met Ser 
        435                 440                 445             


Val His Leu Leu Asn Gln Gly Ser Ser Ile Val Ile Pro Ala Gln His 
    450                 455                 460                 


Met Leu Pro Gly Gln Asn Gln Phe Leu Leu Pro Gly Ala Pro Ala Val 
465                 470                 475                 480 


Gln Leu Pro Gln Gln Leu Ser Ala Leu Pro Ala Asn Val Gly Gly Gln 
                485                 490                 495     


Ile Leu Ala Ala Ala Ala Pro His Thr Gly Gly Gln Leu Ile Ala Asn 
            500                 505                 510         


Pro Ile Leu Thr Asn Gln Asn Leu Ala Gly Pro Leu Ser Leu Gly Pro 
        515                 520                 525             


Val Leu Ala Pro His Ser Gly Ala His Ser Ala His Ile Leu Ser Ala 
    530                 535                 540                 


Ala Pro Ile Gln Val Gly Gln Pro Ala Leu Phe Gln Met Pro Val Ser 
545                 550                 555                 560 


Leu Ala Ala Gly Ser Leu Pro Thr Gln Ser Gln Pro Ala Pro Ala Gly 
                565                 570                 575     


Pro Ala Ala Thr Thr Val Leu Gln Gly Val Thr Leu Pro Pro Ser Ala 
            580                 585                 590         


Val Ala Met Leu Asn Thr Pro Asp Gly Leu Val Gln Pro Ala Thr Pro 
        595                 600                 605             


Ala Ala Ala Thr Gly Glu Ala Ala Pro Val Leu Thr Val Gln Pro Ala 
    610                 615                 620                 


Pro Gln Ala Pro Pro Ala Val Ser Thr Pro Leu Pro Leu Gly Leu Gln 
625                 630                 635                 640 


Gln Pro Gln Ala Gln Gln Pro Pro Gln Ala Pro Thr Pro Gln Ala Ala 
                645                 650                 655     


Ala Pro Pro Gln Ala Thr Thr Pro Gln Pro Ser Pro Gly Leu Ala Ser 
            660                 665                 670         


Ser Pro Glu Lys Ile Val Leu Gly Gln Pro Pro Ser Ala Thr Pro Thr 
        675                 680                 685             


Ala Ile Leu Thr Gln Asp Ser Leu Gln Met Phe Leu Pro Gln Glu Arg 
    690                 695                 700                 


Ser Gln Gln Pro Leu Ser Ala Glu Gly Pro His Leu Ser Val Pro Ala 
705                 710                 715                 720 


Ser Val Ile Val Ser Ala Pro Pro Pro Ala Gln Asp Pro Ala Pro Ala 
                725                 730                 735     


Thr Pro Val Ala Lys Gly Ala Gly Leu Gly Pro Gln Ala Pro Asp Ser 
            740                 745                 750         


Gln Ala Ser Pro Ala Pro Ala Pro Gln Ile Pro Ala Ala Ala Pro Leu 
        755                 760                 765             


Lys Gly Pro Gly Pro Ser Ser Ser Pro Ser Leu Pro His Gln Ala Pro 
    770                 775                 780                 


Leu Gly Asp Ser Pro His Leu Pro Ser Pro His Pro Thr Arg Pro Pro 
785                 790                 795                 800 


Ser Arg Pro Pro Ser Arg Pro Gln Ser Val Ser Arg Pro Pro Ser Glu 
                805                 810                 815     


Pro Pro Leu His Pro Cys Pro Pro Pro Gln Ala Pro Pro Thr Leu Pro 
            820                 825                 830         


Gly Ile Phe Val Ile Gln Asn Gln Leu Gly Val Pro Pro Pro Ala Ser 
        835                 840                 845             


Asn Pro Ala Pro Thr Ala Pro Gly Pro Pro Gln Pro Pro Leu Arg Pro 
    850                 855                 860                 


Gln Ser Gln Pro Pro Glu Gly Pro Leu Pro Pro Ala Pro His Leu Pro 
865                 870                 875                 880 


Pro Ser Ser Thr Ser Ser Ala Val Ala Ser Ser Ser Glu Thr Ser Ser 
                885                 890                 895     


Arg Leu Pro Ala Pro Thr Pro Ser Asp Phe Gln Leu Gln Phe Pro Pro 
            900                 905                 910         


Ser Gln Gly Pro His Lys Ser Pro Thr Pro Pro Pro Thr Leu His Leu 
        915                 920                 925             


Val Pro Glu Pro Ala Ala Pro Pro Pro Pro Pro Pro Arg Thr Phe Gln 
    930                 935                 940                 


Met Val Thr Thr Pro Phe Pro Ala Leu Pro Gln Pro Lys Ala Leu Leu 
945                 950                 955                 960 


Glu Arg Phe His Gln Val Pro Ser Gly Ile Ile Leu Gln Asn Lys Ala 
                965                 970                 975     


Gly Gly Ala Pro Ala Ala Pro Gln Thr Ser Thr Ser Leu Gly Pro Leu 
            980                 985                 990         


Thr Ser Pro Ala Ala Ser Val Leu  Val Ser Gly Gln Ala  Pro Ser Gly 
        995                 1000                 1005             


Thr Pro  Thr Ala Pro Ser His  Ala Pro Ala Pro Ala  Pro Met Ala 
    1010                 1015                 1020             


Ala Thr  Gly Leu Pro Pro Leu  Leu Pro Ala Glu Asn  Lys Ala Phe 
    1025                 1030                 1035             


Ala Ser  Asn Leu Pro Thr Leu  Asn Val Ala Lys Ala  Ala Ser Ser 
    1040                 1045                 1050             


Gly Pro  Gly Lys Pro Ser Gly  Leu Gln Tyr Glu Ser  Lys Leu Ser 
    1055                 1060                 1065             


Gly Leu  Lys Lys Pro Pro Thr  Leu Gln Pro Ser Lys  Glu Ala Cys 
    1070                 1075                 1080             


Phe Leu  Glu His Leu His Lys  His Gln Gly Ser Val  Leu His Pro 
    1085                 1090                 1095             


Asp Tyr  Lys Thr Ala Phe Pro  Ser Phe Glu Asp Ala  Leu His Arg 
    1100                 1105                 1110             


Leu Leu  Pro Tyr His Val Tyr  Gln Gly Ala Leu Pro  Ser Pro Ser 
    1115                 1120                 1125             


Asp Tyr  His Lys Val Asp Glu  Glu Phe Glu Thr Val  Ser Thr Gln 
    1130                 1135                 1140             


Leu Leu  Lys Arg Thr Gln Ala  Met Leu Asn Lys Tyr  Arg Leu Leu 
    1145                 1150                 1155             


Leu Leu  Glu Glu Ser Arg Arg  Val Ser Pro Ser Ala  Glu Met Val 
    1160                 1165                 1170             


Met Ile  Asp Arg Met Phe Ile  Gln Glu Glu Lys Thr  Thr Leu Ala 
    1175                 1180                 1185             


Leu Asp  Lys Gln Leu Ala Lys  Glu Lys Pro Asp Glu  Tyr Val Ser 
    1190                 1195                 1200             


Ser Ser  Arg Ser Leu Gly Leu  Pro Ile Ala Ala Ser  Ser Glu Gly 
    1205                 1210                 1215             


His Arg  Leu Pro Gly His Gly  Pro Leu Ser Ser Ser  Ala Pro Gly 
    1220                 1225                 1230             


Ala Ser  Thr Gln Pro Pro Pro  His Leu Pro Thr Lys  Leu Val Ile 
    1235                 1240                 1245             


Arg His  Gly Gly Ala Gly Gly  Ser Pro Ser Val Thr  Trp Ala Arg 
    1250                 1255                 1260             


Ala Ser  Ser Ser Leu Ser Ser  Ser Ser Ser Ser Ser  Ser Ala Ala 
    1265                 1270                 1275             


Ser Ser  Leu Asp Ala Asp Glu  Asp Gly Pro Met Pro  Ser Arg Asn 
    1280                 1285                 1290             


Arg Pro  Pro Ile Lys Thr Tyr  Glu Ala Arg Ser Arg  Ile Gly Leu 
    1295                 1300                 1305             


Lys Leu  Lys Ile Lys Gln Glu  Ala Gly Leu Ser Lys  Val Val His 
    1310                 1315                 1320             


Asn Thr  Ala Leu Asp Pro Val  His Gln Pro Pro Pro  Pro Pro Ala 
    1325                 1330                 1335             


Thr Leu  Lys Val Ala Glu Pro  Pro Pro Arg Pro Pro  Pro Pro Pro 
    1340                 1345                 1350             


Pro Pro  Thr Gly Gln Met Asn  Gly Thr Val Asp His  Pro Pro Pro 
    1355                 1360                 1365             


Ala Ala  Pro Glu Arg Lys Pro  Leu Gly Thr Ala Pro  His Cys Pro 
    1370                 1375                 1380             


Arg Leu  Pro Leu Arg Lys Thr  Tyr Arg Glu Asn Val  Gly Gly Pro 
    1385                 1390                 1395             


Gly Ala  Pro Glu Gly Thr Pro  Ala Gly Arg Ala Arg  Gly Gly Ser 
    1400                 1405                 1410             


Pro Ala  Pro Leu Pro Ala Lys  Val Asp Glu Ala Thr  Ser Gly Leu 
    1415                 1420                 1425             


Ile Arg  Glu Leu Ala Ala Val  Glu Asp Glu Leu Tyr  Gln Arg Met 
    1430                 1435                 1440             


Leu Lys  Gly Pro Pro Pro Glu  Pro Ala Ala Ser Ala  Ala Gln Gly 
    1445                 1450                 1455             


Thr Gly  Asp Pro Asp Trp Glu  Ala Pro Gly Leu Pro  Pro Ala Lys 
    1460                 1465                 1470             


Arg Arg  Lys Ser Glu Ser Pro  Asp Val Asp Gln Ala  Ser Phe Ser 
    1475                 1480                 1485             


Ser Asp  Ser Pro Gln Asp Asp  Thr Leu Thr Glu His  Leu Gln Ser 
    1490                 1495                 1500             


Ala Ile  Asp Ser Ile Leu Asn  Leu Gln Gln Ala Pro  Gly Arg Thr 
    1505                 1510                 1515             


Pro Ala  Pro Ser Tyr Pro His  Ala Ala Ser Ala Gly  Thr Pro Ala 
    1520                 1525                 1530             


Ser Pro  Pro Pro Leu His Arg  Pro Glu Ala Tyr Pro  Pro Ser Ser 
    1535                 1540                 1545             


His Asn  Gly Gly Leu Gly Ala  Arg Thr Leu Thr Arg  
    1550                 1555                 1560 


<210>  4512
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLTSCR2__Homo_sapiens__NP_056525

<400>  4512

Met Ala Ala Gly Gly Ser Gly Val Gly Gly Lys Arg Ser Ser Lys Ser 
1               5                   10                  15      


Asp Ala Asp Ser Gly Phe Leu Gly Leu Arg Pro Thr Ser Val Asp Pro 
            20                  25                  30          


Ala Leu Arg Arg Arg Arg Arg Gly Pro Arg Asn Lys Lys Arg Gly Trp 
        35                  40                  45              


Arg Arg Leu Ala Gln Glu Pro Leu Gly Leu Glu Val Asp Gln Phe Leu 
    50                  55                  60                  


Glu Asp Val Arg Leu Gln Glu Arg Thr Ser Gly Gly Leu Leu Ser Glu 
65                  70                  75                  80  


Ala Pro Asn Glu Lys Leu Phe Phe Val Asp Thr Gly Ser Lys Glu Lys 
                85                  90                  95      


Gly Leu Thr Lys Lys Arg Thr Lys Val Gln Lys Lys Ser Leu Leu Leu 
            100                 105                 110         


Lys Lys Pro Leu Arg Val Asp Leu Ile Leu Glu Asn Thr Ser Lys Val 
        115                 120                 125             


Pro Ala Pro Lys Asp Val Leu Ala His Gln Val Pro Asn Ala Lys Lys 
    130                 135                 140                 


Leu Arg Arg Lys Glu Gln Leu Trp Glu Lys Leu Ala Lys Gln Gly Glu 
145                 150                 155                 160 


Leu Pro Arg Glu Val Arg Arg Ala Gln Ala Arg Leu Leu Asn Pro Ser 
                165                 170                 175     


Ala Thr Arg Ala Lys Pro Gly Pro Gln Asp Thr Val Glu Arg Pro Phe 
            180                 185                 190         


Tyr Asp Leu Trp Ala Ser Asp Asn Pro Leu Asp Arg Pro Leu Val Gly 
        195                 200                 205             


Gln Asp Glu Phe Phe Leu Glu Gln Thr Lys Lys Lys Gly Val Lys Arg 
    210                 215                 220                 


Pro Ala Arg Leu His Thr Lys Pro Ser Gln Ala Pro Ala Val Glu Val 
225                 230                 235                 240 


Ala Pro Ala Gly Ala Ser Tyr Asn Pro Ser Phe Glu Asp His Gln Thr 
                245                 250                 255     


Leu Leu Ser Ala Ala His Glu Val Glu Leu Gln Arg Gln Lys Glu Ala 
            260                 265                 270         


Glu Lys Leu Glu Arg Gln Leu Ala Leu Pro Ala Thr Glu Gln Ala Ala 
        275                 280                 285             


Thr Gln Glu Ser Thr Phe Gln Glu Leu Cys Glu Gly Leu Leu Glu Glu 
    290                 295                 300                 


Ser Asp Gly Glu Gly Glu Pro Gly Gln Gly Glu Gly Pro Glu Ala Gly 
305                 310                 315                 320 


Asp Ala Glu Val Cys Pro Thr Pro Ala Arg Leu Ala Thr Thr Glu Lys 
                325                 330                 335     


Lys Thr Glu Gln Gln Arg Arg Arg Glu Lys Ala Val His Arg Leu Arg 
            340                 345                 350         


Val Gln Gln Ala Ala Leu Arg Ala Ala Arg Leu Arg His Gln Glu Leu 
        355                 360                 365             


Phe Arg Leu Arg Gly Ile Lys Ala Gln Val Ala Leu Arg Leu Ala Glu 
    370                 375                 380                 


Leu Ala Arg Arg Gln Arg Arg Arg Gln Ala Arg Arg Glu Ala Glu Ala 
385                 390                 395                 400 


Asp Lys Pro Arg Arg Leu Gly Arg Leu Lys Tyr Gln Ala Pro Asp Ile 
                405                 410                 415     


Asp Val Gln Leu Ser Ser Glu Leu Thr Asp Ser Leu Arg Thr Leu Lys 
            420                 425                 430         


Pro Glu Gly Asn Ile Leu Arg Asp Arg Phe Lys Ser Phe Gln Arg Arg 
        435                 440                 445             


Asn Met Ile Glu Pro Arg Glu Arg Ala Lys Phe Lys Arg Lys Tyr Lys 
    450                 455                 460                 


Val Lys Leu Val Glu Lys Arg Ala Phe Arg Glu Ile Gln Leu 
465                 470                 475             


<210>  4513
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLUD1__Homo_sapiens__NP_005262

<400>  4513

Met Tyr Arg Tyr Leu Gly Glu Ala Leu Leu Leu Ser Arg Ala Gly Pro 
1               5                   10                  15      


Ala Ala Leu Gly Ser Ala Ser Ala Asp Ser Ala Ala Leu Leu Gly Trp 
            20                  25                  30          


Ala Arg Gly Gln Pro Ala Ala Ala Pro Gln Pro Gly Leu Ala Leu Ala 
        35                  40                  45              


Ala Arg Arg His Tyr Ser Glu Ala Val Ala Asp Arg Glu Asp Asp Pro 
    50                  55                  60                  


Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile 
65                  70                  75                  80  


Val Glu Asp Lys Leu Val Glu Asp Leu Arg Thr Arg Glu Ser Glu Glu 
                85                  90                  95      


Gln Lys Arg Asn Arg Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys 
            100                 105                 110         


Asn His Val Leu Ser Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser 
        115                 120                 125             


Trp Glu Val Ile Glu Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr 
    130                 135                 140                 


Pro Cys Lys Gly Gly Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu 
145                 150                 155                 160 


Val Lys Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp 
                165                 170                 175     


Val Pro Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn 
            180                 185                 190         


Tyr Thr Asp Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu 
        195                 200                 205             


Leu Ala Lys Lys Gly Phe Ile Gly Pro Gly Ile Asp Val Pro Ala Pro 
    210                 215                 220                 


Asp Met Ser Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr 
225                 230                 235                 240 


Ala Ser Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr 
                245                 250                 255     


Gly Lys Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr 
            260                 265                 270         


Gly Arg Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser 
        275                 280                 285             


Tyr Met Ser Ile Leu Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe 
    290                 295                 300                 


Val Val Gln Gly Phe Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu 
305                 310                 315                 320 


His Arg Phe Gly Ala Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser 
                325                 330                 335     


Ile Trp Asn Pro Asp Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys 
            340                 345                 350         


Leu Gln His Gly Ser Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu 
        355                 360                 365             


Gly Ser Ile Leu Glu Ala Asp Cys Asp Ile Leu Ile Pro Ala Ala Ser 
    370                 375                 380                 


Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile 
385                 390                 395                 400 


Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile 
                405                 410                 415     


Phe Leu Glu Arg Asn Ile Met Val Ile Pro Asp Leu Tyr Leu Asn Ala 
            420                 425                 430         


Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His 
        435                 440                 445             


Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr 
    450                 455                 460                 


His Leu Leu Met Ser Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys 
465                 470                 475                 480 


His Gly Gly Thr Ile Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Arg 
                485                 490                 495     


Ile Ser Gly Ala Ser Glu Lys Asp Ile Val His Ser Gly Leu Ala Tyr 
            500                 505                 510         


Thr Met Glu Arg Ser Ala Arg Gln Ile Met Arg Thr Ala Met Lys Tyr 
        515                 520                 525             


Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu 
    530                 535                 540                 


Lys Val Phe Lys Val Tyr Asn Glu Ala Gly Val Thr Phe Thr 
545                 550                 555             


<210>  4514
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLUD2__Homo_sapiens__NP_036216

<400>  4514

Met Tyr Arg Tyr Leu Ala Lys Ala Leu Leu Pro Ser Arg Ala Gly Pro 
1               5                   10                  15      


Ala Ala Leu Gly Ser Ala Ala Asn His Ser Ala Ala Leu Leu Gly Arg 
            20                  25                  30          


Gly Arg Gly Gln Pro Ala Ala Ala Ser Gln Pro Gly Leu Ala Leu Ala 
        35                  40                  45              


Ala Arg Arg His Tyr Ser Glu Leu Val Ala Asp Arg Glu Asp Asp Pro 
    50                  55                  60                  


Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile 
65                  70                  75                  80  


Val Glu Asp Lys Leu Val Lys Asp Leu Arg Thr Gln Glu Ser Glu Glu 
                85                  90                  95      


Gln Lys Arg Asn Arg Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys 
            100                 105                 110         


Asn His Val Leu Ser Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser 
        115                 120                 125             


Trp Glu Val Ile Glu Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr 
    130                 135                 140                 


Pro Cys Lys Gly Gly Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu 
145                 150                 155                 160 


Val Lys Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp 
                165                 170                 175     


Val Pro Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn 
            180                 185                 190         


Tyr Thr Glu Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu 
        195                 200                 205             


Leu Ala Lys Lys Gly Phe Ile Gly Pro Gly Val Asp Val Pro Ala Pro 
    210                 215                 220                 


Asp Met Asn Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr 
225                 230                 235                 240 


Ala Ser Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr 
                245                 250                 255     


Gly Lys Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr 
            260                 265                 270         


Gly Arg Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser 
        275                 280                 285             


Tyr Met Ser Ile Leu Gly Met Thr Pro Gly Phe Arg Asp Lys Thr Phe 
    290                 295                 300                 


Val Val Gln Gly Phe Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu 
305                 310                 315                 320 


His Arg Phe Gly Ala Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser 
                325                 330                 335     


Ile Trp Asn Pro Asp Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys 
            340                 345                 350         


Leu Gln His Gly Ser Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu 
        355                 360                 365             


Gly Ser Ile Leu Glu Val Asp Cys Asp Ile Leu Ile Pro Ala Ala Thr 
    370                 375                 380                 


Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile 
385                 390                 395                 400 


Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile 
                405                 410                 415     


Phe Leu Glu Arg Asn Ile Leu Val Ile Pro Asp Leu Tyr Leu Asn Ala 
            420                 425                 430         


Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His 
        435                 440                 445             


Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr 
    450                 455                 460                 


His Leu Leu Leu Ser Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys 
465                 470                 475                 480 


His Gly Gly Thr Ile Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Ser 
                485                 490                 495     


Ile Ser Gly Ala Ser Glu Lys Asp Ile Val His Ser Ala Leu Ala Tyr 
            500                 505                 510         


Thr Met Glu Arg Ser Ala Arg Gln Ile Met His Thr Ala Met Lys Tyr 
        515                 520                 525             


Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu 
    530                 535                 540                 


Lys Val Phe Lys Val Tyr Ser Glu Ala Gly Val Thr Phe Thr 
545                 550                 555             


<210>  4515
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLUL__Homo_sapiens__XP_006711341

<400>  4515

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  4516
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLYAT__Homo_sapiens__NP_005829

<400>  4516

Met Met Leu Pro Leu Gln Gly Ala Gln Met Leu Gln Met Leu Glu Lys 
1               5                   10                  15      


Ser Leu Arg Lys Ser Leu Pro Ala Ser Leu Lys Val Tyr Gly Thr Val 
            20                  25                  30          


Phe His Ile Asn His Gly Asn Pro Phe Asn Leu Lys Ala Val Val Asp 
        35                  40                  45              


Lys Trp Pro Asp Phe Asn Thr Val Val Val Cys Pro Gln Glu Gln Asp 
    50                  55                  60                  


Met Thr Asp Asp Leu Asp His Tyr Thr Asn Thr Tyr Gln Ile Tyr Ser 
65                  70                  75                  80  


Lys Asp Pro Gln Asn Cys Gln Glu Phe Leu Gly Ser Pro Glu Leu Ile 
                85                  90                  95      


Asn Trp Lys Gln His Leu Gln Ile Gln Ser Ser Gln Pro Ser Leu Asn 
            100                 105                 110         


Glu Ala Ile Gln Asn Leu Ala Ala Ile Lys Ser Phe Lys Val Lys Gln 
        115                 120                 125             


Thr Gln Arg Ile Leu Tyr Met Ala Ala Glu Thr Ala Lys Glu Leu Thr 
    130                 135                 140                 


Pro Phe Leu Leu Lys Ser Lys Ile Leu Ser Pro Asn Gly Gly Lys Pro 
145                 150                 155                 160 


Lys Ala Met 
            


<210>  4517
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLYATL3__Homo_sapiens__NP_001010904

<400>  4517

Met Leu Val Leu Asn Cys Ser Thr Lys Leu Leu Ile Leu Glu Lys Met 
1               5                   10                  15      


Leu Lys Ser Cys Phe Pro Glu Ser Leu Lys Val Tyr Gly Ala Val Met 
            20                  25                  30          


Asn Ile Asn Arg Gly Asn Pro Phe Gln Lys Glu Val Val Leu Asp Ser 
        35                  40                  45              


Trp Pro Asp Phe Lys Ala Val Ile Thr Arg Arg Gln Arg Glu Ala Glu 
    50                  55                  60                  


Thr Asp Asn Leu Asp His Tyr Thr Asn Ala Tyr Ala Val Phe Tyr Lys 
65                  70                  75                  80  


Asp Val Arg Ala Tyr Arg Gln Leu Leu Glu Glu Cys Asp Val Phe Asn 
                85                  90                  95      


Trp Asp Gln Val Phe Gln Ile Gln Gly Leu Gln Ser Glu Leu Tyr Asp 
            100                 105                 110         


Val Ser Lys Ala Val Ala Asn Ser Lys Gln Leu Asn Ile Lys Leu Thr 
        115                 120                 125             


Ser Phe Lys Ala Val His Phe Ser Pro Val Ser Ser Leu Pro Asp Thr 
    130                 135                 140                 


Ser Phe Leu Lys Gly Pro Ser Pro Arg Leu Thr Tyr Leu Ser Val Ala 
145                 150                 155                 160 


Asn Ala Asp Leu Leu Asn Arg Thr Trp Ser Arg Gly Gly Asn Glu Gln 
                165                 170                 175     


Cys Leu Arg Tyr Ile Ala Asn Leu Ile Ser Cys Phe Pro Ser Val Cys 
            180                 185                 190         


Val Arg Asp Glu Lys Gly Asn Pro Val Ser Trp Ser Ile Thr Asp Gln 
        195                 200                 205             


Phe Ala Thr Met Cys His Gly Tyr Thr Leu Pro Glu His Arg Arg Lys 
    210                 215                 220                 


Gly Tyr Ser Arg Leu Val Ala Leu Thr Leu Ala Arg Lys Leu Gln Ser 
225                 230                 235                 240 


Arg Gly Phe Pro Ser Gln Gly Asn Val Leu Asp Asp Asn Thr Ala Ser 
                245                 250                 255     


Ile Ser Leu Leu Lys Ser Leu His Ala Glu Phe Leu Pro Cys Arg Phe 
            260                 265                 270         


His Arg Leu Ile Leu Thr Pro Ala Thr Phe Ser Gly Leu Pro His Leu 
        275                 280                 285             


<210>  4518
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLYCTK__Homo_sapiens__NP_001138423

<400>  4518

Met Ala Ala Ala Leu Gln Val Leu Pro Arg Leu Ala Arg Ala Pro Leu 
1               5                   10                  15      


His Pro Leu Leu Trp Arg Gly Ser Val Ala Arg Leu Ala Ser Ser Met 
            20                  25                  30          


Ala Leu Ala Glu Gln Ala Arg Gln Leu Phe Glu Ser Ala Val Gly Ala 
        35                  40                  45              


Val Leu Pro Gly Pro Met Leu His Arg Ala Leu Ser Leu Asp Pro Gly 
    50                  55                  60                  


Gly Arg Gln Leu Lys Val Arg Asp Arg Asn Phe Gln Leu Arg Gln Asn 
65                  70                  75                  80  


Leu Tyr Leu Val Gly Phe Gly Lys Ala Val Leu Gly Met Ala Ala Ala 
                85                  90                  95      


Ala Glu Glu Leu Leu Gly Gln His Leu Val Gln Gly Val Ile Ser Val 
            100                 105                 110         


Pro Lys Gly Ile Arg Ala Ala Met Glu Arg Ala Gly Lys Gln Glu Met 
        115                 120                 125             


Leu Leu Lys Pro His Ser Arg Val Gln Val Phe Glu Gly Ala Glu Asp 
    130                 135                 140                 


Asn Leu Pro Asp Arg Asp Ala Leu Arg Ala Ala Leu Ala Ile Gln Gln 
145                 150                 155                 160 


Leu Ala Glu Gly Leu Thr Ala Asp Asp Leu Leu Leu Val Leu Ile Ser 
                165                 170                 175     


Gly Gly Glu Pro His Pro Val Arg Cys Gly Gly Gly Pro Cys Gly Gly 
            180                 185                 190         


Asp Cys Gln Trp Pro His Arg Gly Gln Phe Pro Gln Cys Ala Arg Leu 
        195                 200                 205             


Pro Ala Tyr Pro Gln Ser Leu Arg Pro Pro Cys Ser Pro Ala Thr Phe 
    210                 215                 220                 


Cys Glu Asp Cys Ala Val Ser Gly Arg Leu 
225                 230                 


<210>  4519
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GM2A__Homo_sapiens__NP_000396

<400>  4519

Met Gln Ser Leu Met Gln Ala Pro Leu Leu Ile Ala Leu Gly Leu Leu 
1               5                   10                  15      


Leu Ala Ala Pro Ala Gln Ala His Leu Lys Lys Pro Ser Gln Leu Ser 
            20                  25                  30          


Ser Phe Ser Trp Asp Asn Cys Asp Glu Gly Lys Asp Pro Ala Val Ile 
        35                  40                  45              


Arg Ser Leu Thr Leu Glu Pro Asp Pro Ile Ile Val Pro Gly Asn Val 
    50                  55                  60                  


Thr Leu Ser Val Met Gly Ser Thr Ser Val Pro Leu Ser Ser Pro Leu 
65                  70                  75                  80  


Lys Val Asp Leu Val Leu Glu Lys Glu Val Ala Gly Leu Trp Ile Lys 
                85                  90                  95      


Ile Pro Cys Thr Asp Tyr Ile Gly Ser Cys Thr Phe Glu His Phe Cys 
            100                 105                 110         


Asp Val Leu Asp Met Leu Ile Pro Thr Gly Glu Pro Cys Pro Glu Pro 
        115                 120                 125             


Leu Arg Thr Tyr Gly Leu Pro Cys His Cys Pro Phe Lys Glu Gly Thr 
    130                 135                 140                 


Tyr Ser Leu Pro Lys Ser Glu Phe Val Val Pro Asp Leu Glu Leu Pro 
145                 150                 155                 160 


Ser Trp Leu Thr Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser Ser 
                165                 170                 175     


Ser Gly Lys Arg Leu Gly Cys Ile Lys Ile Ala Ala Ser Leu Lys Gly 
            180                 185                 190         


Ile 
    


<210>  4520
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMCL1__Homo_sapiens__NP_848526

<400>  4520

Met Gly Ser Leu Ser Ser Arg Val Leu Arg Gln Pro Arg Pro Ala Leu 
1               5                   10                  15      


Ala Gln Gln Ala Gln Gly Ala Arg Ala Gly Gly Ser Ala Arg Arg Pro 
            20                  25                  30          


Asp Thr Gly Asp Asp Ala Ala Gly His Gly Phe Cys Tyr Cys Ala Gly 
        35                  40                  45              


Ser His Lys Arg Lys Arg Ser Ser Gly Ser Phe Cys Tyr Cys His Pro 
    50                  55                  60                  


Asp Ser Glu Thr Asp Glu Asp Glu Glu Glu Gly Asp Glu Gln Gln Arg 
65                  70                  75                  80  


Leu Leu Asn Thr Pro Arg Arg Lys Lys Leu Lys Ser Thr Ser Lys Tyr 
                85                  90                  95      


Ile Tyr Gln Thr Leu Phe Leu Asn Gly Glu Asn Ser Asp Ile Lys Ile 
            100                 105                 110         


Cys Ala Leu Gly Glu Glu Trp Ser Leu His Lys Ile Tyr Leu Cys Gln 
        115                 120                 125             


Ser Gly Tyr Phe Ser Ser Met Phe Ser Gly Ser Trp Lys Glu Ser Ser 
    130                 135                 140                 


Met Asn Ile Ile Glu Leu Glu Ile Pro Asp Gln Asn Ile Asp Val Glu 
145                 150                 155                 160 


Ala Leu Gln Val Ala Phe Gly Ser Leu Tyr Arg Asp Asp Val Leu Ile 
                165                 170                 175     


Lys Pro Ser Arg Val Val Ala Ile Leu Ala Ala Ala Cys Leu Leu Gln 
            180                 185                 190         


Leu Asp Gly Leu Ile Gln Gln Cys Gly Glu Thr Met Lys Glu Thr Val 
        195                 200                 205             


Asn Val Lys Thr Val Cys Gly Tyr Tyr Thr Ser Ala Gly Thr Tyr Gly 
    210                 215                 220                 


Leu Asp Ser Val Lys Lys Lys Cys Leu Glu Trp Leu Leu Asn Asn Leu 
225                 230                 235                 240 


Met Thr His Gln Asn Val Glu Leu Phe Lys Glu Leu Ser Ile Asn Val 
                245                 250                 255     


Met Lys Gln Leu Ile Gly Ser Ser Asn Leu Phe Val Met Gln Val Glu 
            260                 265                 270         


Met Asp Ile Tyr Thr Ala Leu Lys Lys Trp Met Phe Leu Gln Leu Val 
        275                 280                 285             


Pro Ser Trp Asn Gly Ser Leu Lys Gln Leu Leu Thr Glu Thr Asp Val 
    290                 295                 300                 


Trp Phe Ser Lys Gln Arg Lys Asp Phe Glu Gly Met Ala Phe Leu Glu 
305                 310                 315                 320 


Thr Glu Gln Gly Lys Pro Phe Val Ser Val Phe Arg His Leu Arg Leu 
                325                 330                 335     


Gln Tyr Ile Ile Ser Asp Leu Ala Ser Ala Arg Ile Ile Glu Gln Asp 
            340                 345                 350         


Ala Val Val Pro Ser Glu Trp Leu Ser Ser Val Tyr Lys Gln Gln Trp 
        355                 360                 365             


Phe Ala Met Leu Arg Ala Glu Gln Asp Ser Glu Val Gly Pro Gln Glu 
    370                 375                 380                 


Ile Asn Lys Glu Glu Leu Glu Gly Asn Ser Met Arg Cys Gly Arg Lys 
385                 390                 395                 400 


Leu Ala Lys Asp Gly Glu Tyr Cys Trp Arg Trp Thr Gly Phe Asn Phe 
                405                 410                 415     


Gly Phe Asp Leu Leu Val Thr Tyr Thr Asn Arg Tyr Ile Ile Phe Lys 
            420                 425                 430         


Arg Asn Thr Leu Asn Gln Pro Cys Ser Gly Ser Val Ser Leu Gln Pro 
        435                 440                 445             


Arg Arg Ser Ile Ala Phe Arg Leu Arg Leu Ala Ser Phe Asp Ser Ser 
    450                 455                 460                 


Gly Lys Leu Ile Cys Ser Arg Thr Thr Gly Tyr Gln Ile Leu Thr Leu 
465                 470                 475                 480 


Glu Lys Asp Gln Glu Gln Val Val Met Asn Leu Asp Ser Arg Leu Leu 
                485                 490                 495     


Ile Phe Pro Leu Tyr Ile Cys Cys Asn Phe Leu Tyr Ile Ser Pro Glu 
            500                 505                 510         


Lys Lys Asn 
        515 


<210>  4521
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMDS__Homo_sapiens__NP_001240775

<400>  4521

Met Cys Lys Met Asp Gly Ser Tyr Leu Ala Glu Phe Leu Leu Glu Lys 
1               5                   10                  15      


Gly Tyr Glu Val His Gly Ile Val Arg Arg Ser Ser Ser Phe Asn Thr 
            20                  25                  30          


Gly Arg Ile Glu His Leu Tyr Lys Asn Pro Gln Ala His Ile Glu Gly 
        35                  40                  45              


Asn Met Lys Leu His Tyr Gly Asp Leu Thr Asp Ser Thr Cys Leu Val 
    50                  55                  60                  


Lys Ile Ile Asn Glu Val Lys Pro Thr Glu Ile Tyr Asn Leu Gly Ala 
65                  70                  75                  80  


Gln Ser His Val Lys Ile Ser Phe Asp Leu Ala Glu Tyr Thr Ala Asp 
                85                  90                  95      


Val Asp Gly Val Gly Thr Leu Arg Leu Leu Asp Ala Val Lys Thr Cys 
            100                 105                 110         


Gly Leu Ile Asn Ser Val Lys Phe Tyr Gln Ala Ser Thr Ser Glu Leu 
        115                 120                 125             


Tyr Gly Lys Val Gln Glu Ile Pro Gln Lys Glu Thr Thr Pro Phe Tyr 
    130                 135                 140                 


Pro Arg Ser Pro Tyr Gly Ala Ala Lys Leu Tyr Ala Tyr Trp Ile Val 
145                 150                 155                 160 


Val Asn Phe Arg Glu Ala Tyr Asn Leu Phe Ala Val Asn Gly Ile Leu 
                165                 170                 175     


Phe Asn His Glu Ser Pro Arg Arg Gly Ala Asn Phe Val Thr Arg Lys 
            180                 185                 190         


Ile Ser Arg Ser Val Ala Lys Ile Tyr Leu Gly Gln Leu Glu Cys Phe 
        195                 200                 205             


Ser Leu Gly Asn Leu Asp Ala Lys Arg Asp Trp Gly His Ala Lys Asp 
    210                 215                 220                 


Tyr Val Glu Ala Met Trp Leu Met Leu Gln Asn Asp Glu Pro Glu Asp 
225                 230                 235                 240 


Phe Val Ile Ala Thr Gly Glu Val His Ser Val Arg Glu Phe Val Glu 
                245                 250                 255     


Lys Ser Phe Leu His Ile Gly Lys Thr Ile Val Trp Glu Gly Lys Asn 
            260                 265                 270         


Glu Asn Glu Val Gly Arg Cys Lys Glu Thr Gly Lys Val His Val Thr 
        275                 280                 285             


Val Asp Leu Lys Tyr Tyr Arg Pro Thr Glu Val Asp Phe Leu Gln Gly 
    290                 295                 300                 


Asp Cys Thr Lys Ala Lys Gln Lys Leu Asn Trp Lys Pro Arg Val Ala 
305                 310                 315                 320 


Phe Asp Glu Leu Val Arg Glu Met Val His Ala Asp Val Glu Leu Met 
                325                 330                 335     


Arg Thr Asn Pro Asn Ala 
            340         


<210>  4522
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMFB__Homo_sapiens__NP_004115

<400>  4522

Met Ser Glu Ser Leu Val Val Cys Asp Val Ala Glu Asp Leu Val Glu 
1               5                   10                  15      


Lys Leu Arg Lys Phe Arg Phe Arg Lys Glu Thr Asn Asn Ala Ala Ile 
            20                  25                  30          


Ile Met Lys Ile Asp Lys Asp Lys Arg Leu Val Val Leu Asp Glu Glu 
        35                  40                  45              


Leu Glu Gly Ile Ser Pro Asp Glu Leu Lys Asp Glu Leu Pro Glu Arg 
    50                  55                  60                  


Gln Pro Arg Phe Ile Val Tyr Ser Tyr Lys Tyr Gln His Asp Asp Gly 
65                  70                  75                  80  


Arg Val Ser Tyr Pro Leu Cys Phe Ile Phe Ser Ser Pro Val Gly Cys 
                85                  90                  95      


Lys Pro Glu Gln Gln Met Met Tyr Ala Gly Ser Lys Asn Lys Leu Val 
            100                 105                 110         


Gln Thr Ala Glu Leu Thr Lys Val Phe Glu Ile Arg Asn Thr Glu Asp 
        115                 120                 125             


Leu Thr Glu Glu Trp Leu Arg Glu Lys Leu Gly Phe Phe His 
    130                 135                 140         


<210>  4523
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMFG__Homo_sapiens__NP_004868

<400>  4523

Met Ser Asp Ser Leu Val Val Cys Glu Val Asp Pro Glu Leu Thr Glu 
1               5                   10                  15      


Lys Leu Arg Lys Phe Arg Phe Arg Lys Glu Thr Asp Asn Ala Ala Ile 
            20                  25                  30          


Ile Met Lys Val Asp Lys Asp Arg Gln Met Val Val Leu Glu Glu Glu 
        35                  40                  45              


Phe Gln Asn Ile Ser Pro Glu Glu Leu Lys Met Glu Leu Pro Glu Arg 
    50                  55                  60                  


Gln Pro Arg Phe Val Val Tyr Ser Tyr Lys Tyr Val His Asp Asp Gly 
65                  70                  75                  80  


Arg Val Ser Tyr Pro Leu Cys Phe Ile Phe Ser Ser Pro Val Gly Cys 
                85                  90                  95      


Lys Pro Glu Gln Gln Met Met Tyr Ala Gly Ser Lys Asn Arg Leu Val 
            100                 105                 110         


Gln Thr Ala Glu Leu Thr Lys Val Phe Glu Ile Arg Thr Thr Asp Asp 
        115                 120                 125             


Leu Thr Glu Ala Trp Leu Gln Glu Lys Leu Ser Phe Phe Arg 
    130                 135                 140         


<210>  4524
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMIP__Homo_sapiens__NP_001275927

<400>  4524

Met Asp Ala Ala Glu Pro Gly Leu Pro Pro Gly Pro Glu Gly Arg Lys 
1               5                   10                  15      


Arg Tyr Ser Asp Ile Phe Arg Ser Leu Asp Asn Leu Glu Ile Ser Leu 
            20                  25                  30          


Gly Asn Val Thr Leu Glu Met Leu Ala Gly Asp Pro Leu Leu Ser Glu 
        35                  40                  45              


Asp Pro Glu Pro Asp Lys Thr Pro Thr Ala Thr Val Thr Asn Glu Ala 
    50                  55                  60                  


Ser Cys Trp Ser Gly Pro Ser Pro Glu Gly Pro Val Pro Leu Thr Gly 
65                  70                  75                  80  


Glu Glu Leu Asp Leu Arg Leu Ile Arg Thr Lys Gly Gly Val Asp Ala 
                85                  90                  95      


Ala Leu Glu Tyr Ala Lys Thr Trp Ser Arg Tyr Ala Lys Glu Leu Leu 
            100                 105                 110         


Ala Trp Thr Glu Lys Arg Ala Ser Tyr Glu Leu Glu Phe Ala Lys Ser 
        115                 120                 125             


Thr Met Lys Ile Ala Glu Ala Gly Lys Val Ser Ile Gln Gln Gln Ser 
    130                 135                 140                 


His Met Pro Leu Gln Tyr Ile Tyr Thr Leu Phe Leu Glu His Asp Leu 
145                 150                 155                 160 


Ser Leu Gly Thr Leu Ala Met Glu Thr Val Ala Gln Gln Lys Arg Asp 
                165                 170                 175     


Tyr Tyr Gln Pro Leu Ala Ala Lys Arg Thr Glu Ile Glu Lys Trp Arg 
            180                 185                 190         


Lys Glu Phe Lys Glu Gln Trp Met Lys Glu Gln Lys Arg Met Asn Glu 
        195                 200                 205             


Ala Val Gln Ala Leu Arg Arg Ala Gln Leu Gln Tyr Val Gln Arg Ser 
    210                 215                 220                 


Glu Asp Leu Arg Ala Arg Ser Gln Gly Ser Pro Glu Asp Ser Ala Pro 
225                 230                 235                 240 


Gln Ala Ser Pro Gly Pro Ser Lys Gln Gln Glu Arg Arg Arg Arg Ser 
                245                 250                 255     


Arg Glu Glu Ala Gln Ala Lys Ala Gln Glu Ala Glu Ala Leu Tyr Gln 
            260                 265                 270         


Ala Cys Val Arg Glu Ala Asn Ala Arg Gln Gln Asp Leu Glu Ile Ala 
        275                 280                 285             


Lys Gln Arg Ile Val Ser His Val Arg Lys Leu Val Phe Gln Gly Asp 
    290                 295                 300                 


Glu Val Leu Arg Arg Val Thr Leu Ser Leu Phe Gly Leu Arg Gly Ala 
305                 310                 315                 320 


Gln Ala Glu Arg Gly Pro Arg Ala Phe Ala Ala Leu Ala Glu Cys Cys 
                325                 330                 335     


Ala Pro Phe Glu Pro Gly Gln Arg Tyr Gln Glu Phe Val Arg Ala Leu 
            340                 345                 350         


Arg Pro Glu Ala Pro Pro Pro Pro Pro Pro Ala Phe Ser Phe Gln Glu 
        355                 360                 365             


Phe Leu Pro Ser Leu Asn Ser Ser Pro Leu Asp Ile Arg Lys Lys Leu 
    370                 375                 380                 


Ser Gly Pro Leu Pro Pro Arg Leu Asp Glu Asn Ser Ala Glu Pro Gly 
385                 390                 395                 400 


Pro Trp Glu Asp Pro Gly Thr Gly Trp Arg Trp Gln Gly Pro Thr Pro 
                405                 410                 415     


Gly Ser Asp Val Asp Ser Val Gly Gly Gly Ser Glu Ser Arg Ser Leu 
            420                 425                 430         


Asp Ser Pro Thr Ser Ser Pro Asp Leu Gly Asp Gly Leu Glu Asn Gly 
        435                 440                 445             


Leu Gly Ser Pro Phe Gly Lys Trp Thr Leu Ser Ser Ala Ala Gln Thr 
    450                 455                 460                 


His Gln Leu Arg Arg Leu Arg Gly Pro Ala Lys Cys Arg Glu Cys Glu 
465                 470                 475                 480 


Ala Phe Met Val Ser Gly Thr Glu Cys Glu Glu Cys Phe Leu Thr Cys 
                485                 490                 495     


His Lys Arg Cys Leu Glu Thr Leu Leu Ile Leu Cys Gly His Arg Arg 
            500                 505                 510         


Leu Pro Ala Arg Thr Pro Leu Phe Gly Val Asp Phe Leu Gln Leu Pro 
        515                 520                 525             


Arg Asp Phe Pro Glu Glu Val Pro Phe Val Val Thr Lys Cys Thr Ala 
    530                 535                 540                 


Glu Ile Glu His Arg Ala Leu Asp Val Gln Gly Ile Tyr Arg Val Ser 
545                 550                 555                 560 


Gly Ser Arg Val Arg Val Glu Arg Leu Cys Gln Ala Phe Glu Asn Gly 
                565                 570                 575     


Arg Ala Leu Val Glu Leu Ser Gly Asn Ser Pro His Asp Val Ser Ser 
            580                 585                 590         


Val Leu Lys Arg Phe Leu Gln Glu Leu Thr Glu Pro Val Ile Pro Phe 
        595                 600                 605             


His Leu Tyr Asp Ala Phe Ile Ser Leu Ala Lys Thr Leu His Ala Asp 
    610                 615                 620                 


Pro Gly Asp Asp Pro Gly Thr Pro Ser Pro Ser Pro Glu Val Ile Arg 
625                 630                 635                 640 


Ser Leu Lys Thr Leu Leu Val Gln Leu Pro Asp Ser Asn Tyr Asn Thr 
                645                 650                 655     


Leu Arg His Leu Val Ala His Leu Phe Arg Val Ala Ala Arg Phe Met 
            660                 665                 670         


Glu Asn Lys Met Ser Ala Asn Asn Leu Gly Ile Val Phe Gly Pro Thr 
        675                 680                 685             


Leu Leu Arg Pro Pro Asp Gly Pro Arg Ala Ala Ser Ala Ile Pro Val 
    690                 695                 700                 


Thr Cys Leu Leu Asp Ser Gly His Gln Ala Gln Leu Val Glu Phe Leu 
705                 710                 715                 720 


Ile Val His Tyr Glu Gln Ile Phe Gly Met Asp Glu Leu Pro Gln Ala 
                725                 730                 735     


Thr Glu Pro Pro Pro Gln Asp Ser Ser Pro Ala Pro Gly Pro Leu Thr 
            740                 745                 750         


Thr Ser Ser Gln Pro Pro Pro Pro His Leu Asp Pro Asp Ser Gln Pro 
        755                 760                 765             


Pro Val Leu Ala Ser Asp Pro Gly Pro Asp Pro Gln His His Ser Thr 
    770                 775                 780                 


Leu Glu Gln His Pro Thr Ala Thr Pro Thr Glu Ile Pro Thr Pro Gln 
785                 790                 795                 800 


Ser Asp Gln Arg Glu Asp Val Ala Glu Asp Thr Lys Asp Gly Gly Gly 
                805                 810                 815     


Glu Val Ser Ser Gln Gly Pro Glu Asp Ser Leu Leu Gly Thr Gln Ser 
            820                 825                 830         


Arg Gly His Phe Ser Arg Gln Pro Val Lys Tyr Pro Arg Gly Gly Val 
        835                 840                 845             


Arg Pro Val Thr His Gln Leu Ser Ser Leu Ala Leu Val Ala Ser Lys 
    850                 855                 860                 


Leu Cys Glu Glu Thr Pro Ile Thr Ser Val Pro Arg Gly Ser Leu Arg 
865                 870                 875                 880 


Gly Arg Gly Pro Ser Pro Ala Ala Ala Ser Pro Glu Gly Ser Pro Leu 
                885                 890                 895     


Arg Arg Thr Pro Leu Pro Lys His Phe Glu Ile Thr Gln Glu Thr Ala 
            900                 905                 910         


Arg Leu Leu Ser Lys Leu Asp Ser Glu Ala Val Pro Arg Ala Thr Cys 
        915                 920                 925             


Cys Pro Asp Val Gln Pro Glu Glu Ala Glu Asp His Leu 
    930                 935                 940     


<210>  4525
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GML__Homo_sapiens__XP_011515271

<400>  4525

Met Glu Pro Gly Ser Arg Leu Leu Arg Glu Val Met Leu Leu Phe Ala 
1               5                   10                  15      


Leu Leu Leu Ala Met Glu Leu Pro Leu Val Ala Ala Ser Ala Thr Met 
            20                  25                  30          


Arg Ala Gln Trp Thr Tyr Ser Leu Arg Cys His Asp Cys Ala Val Ile 
        35                  40                  45              


Asn Asp Phe Asn Cys Pro Asn Ile Arg Val Cys Pro Tyr His Ile Arg 
    50                  55                  60                  


Arg Cys Met Thr Ile Ser Ile Arg Ile Asn Ser Arg Glu Leu Leu Val 
65                  70                  75                  80  


Tyr Lys Asn Cys Thr Asn Asn Cys Thr Phe Val Tyr Ala Ala Glu Gln 
                85                  90                  95      


Pro Pro Glu Ala Pro Gly Lys Ile Phe Lys Thr Asn Ser Phe Tyr Trp 
            100                 105                 110         


Val Cys Cys Cys Asn Ser Met Val Cys Asn Ala Gly Gly Pro Thr Asn 
        115                 120                 125             


Leu Glu Arg Asp Met Leu Pro Asp Glu Val Thr Glu Glu Glu Leu Pro 
    130                 135                 140                 


Glu Gly Thr Val Arg Leu Gly Val Ser Lys Leu Leu Leu Ser Phe Ala 
145                 150                 155                 160 


Ser Ile Ile Val Ser Asn Ile Leu Pro 
                165                 


<210>  4526
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMNN__Homo_sapiens__XP_005249216

<400>  4526

Met Asn Pro Ser Met Lys Gln Lys Gln Glu Glu Ile Lys Glu Asn Ile 
1               5                   10                  15      


Lys Asn Ser Ser Val Pro Arg Arg Thr Leu Lys Met Ile Gln Pro Ser 
            20                  25                  30          


Ala Ser Gly Ser Leu Val Gly Arg Glu Asn Glu Leu Ser Ala Gly Leu 
        35                  40                  45              


Ser Lys Arg Lys His Arg Asn Asp His Leu Thr Ser Thr Thr Ser Ser 
    50                  55                  60                  


Pro Gly Val Ile Val Pro Glu Ser Ser Glu Asn Lys Asn Leu Gly Gly 
65                  70                  75                  80  


Val Thr Gln Glu Ser Phe Asp Leu Met Ile Lys Glu Asn Pro Ser Ser 
                85                  90                  95      


Gln Tyr Trp Lys Glu Val Ala Glu Lys Arg Arg Lys Ala Leu Tyr Glu 
            100                 105                 110         


Ala Leu Lys Glu Asn Glu Lys Leu His Lys Glu Ile Glu Gln Lys Asp 
        115                 120                 125             


Asn Glu Ile Ala Arg Leu Lys Lys Glu Asn Lys Glu Leu Ala Glu Val 
    130                 135                 140                 


Ala Glu His Val Gln Tyr Met Ala Glu Leu Ile Glu Arg Leu Asn Gly 
145                 150                 155                 160 


Glu Pro Leu Asp Asn Phe Glu Ser Leu Asp Asn Gln Glu Phe Asp Ser 
                165                 170                 175     


Glu Glu Glu Thr Val Glu Asp Ser Leu Val Glu Asp Ser Glu Ile Gly 
            180                 185                 190         


Thr Cys Ala Glu Gly Thr Val Ser Ser Ser Thr Asp Ala Lys Pro Cys 
        195                 200                 205             


Ile 
    


<210>  4527
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMPPA__Homo_sapiens__NP_995319

<400>  4527

Met Leu Lys Ala Val Ile Leu Ile Gly Gly Pro Gln Lys Gly Thr Arg 
1               5                   10                  15      


Phe Arg Pro Leu Ser Phe Glu Val Pro Lys Pro Leu Phe Pro Val Ala 
            20                  25                  30          


Gly Val Pro Met Ile Gln His His Ile Glu Ala Cys Ala Gln Val Pro 
        35                  40                  45              


Gly Met Gln Glu Ile Leu Leu Ile Gly Phe Tyr Gln Pro Asp Glu Pro 
    50                  55                  60                  


Leu Thr Gln Phe Leu Glu Ala Ala Gln Gln Glu Phe Asn Leu Pro Val 
65                  70                  75                  80  


Arg Tyr Leu Gln Glu Phe Ala Pro Leu Gly Thr Gly Gly Gly Leu Tyr 
                85                  90                  95      


His Phe Arg Asp Gln Ile Leu Ala Gly Ser Pro Glu Ala Phe Phe Val 
            100                 105                 110         


Leu Asn Ala Asp Val Cys Ser Asp Phe Pro Leu Ser Ala Met Leu Glu 
        115                 120                 125             


Ala His Arg Arg Gln Arg His Pro Phe Leu Leu Leu Gly Thr Thr Ala 
    130                 135                 140                 


Asn Arg Thr Gln Ser Leu Asn Tyr Gly Cys Ile Val Glu Asn Pro Gln 
145                 150                 155                 160 


Thr His Glu Val Leu His Tyr Val Glu Lys Pro Ser Thr Phe Ile Ser 
                165                 170                 175     


Asp Ile Ile Asn Cys Gly Ile Tyr Leu Phe Ser Pro Glu Ala Leu Lys 
            180                 185                 190         


Pro Leu Arg Asp Val Phe Gln Arg Asn Gln Gln Asp Gly Gln Leu Glu 
        195                 200                 205             


Asp Ser Pro Gly Leu Trp Pro Gly Ala Gly Thr Ile Arg Leu Glu Gln 
    210                 215                 220                 


Asp Val Phe Ser Ala Leu Ala Gly Gln Gly Gln Ile Tyr Val His Leu 
225                 230                 235                 240 


Thr Asp Gly Ile Trp Ser Gln Ile Lys Ser Ala Gly Ser Ala Leu Tyr 
                245                 250                 255     


Ala Ser Arg Leu Tyr Leu Ser Arg Tyr Gln Asp Thr His Pro Glu Arg 
            260                 265                 270         


Leu Ala Lys His Thr Pro Gly Gly Pro Trp Ile Arg Gly Asn Val Tyr 
        275                 280                 285             


Ile His Pro Thr Ala Lys Val Ala Pro Ser Ala Val Leu Gly Pro Asn 
    290                 295                 300                 


Val Ser Ile Gly Lys Gly Val Thr Val Gly Glu Gly Val Arg Leu Arg 
305                 310                 315                 320 


Glu Ser Ile Val Leu His Gly Ala Thr Leu Gln Glu His Thr Cys Val 
                325                 330                 335     


Leu His Ser Ile Val Gly Trp Gly Ser Thr Val Gly Arg Trp Ala Arg 
            340                 345                 350         


Val Glu Gly Thr Pro Ser Asp Pro Asn Pro Asn Asp Pro Arg Ala Arg 
        355                 360                 365             


Met Asp Ser Glu Ser Leu Phe Lys Asp Gly Lys Leu Leu Pro Ala Ile 
    370                 375                 380                 


Thr Ile Leu Gly Cys Arg Val Arg Ile Pro Ala Glu Val Leu Ile Leu 
385                 390                 395                 400 


Asn Ser Ile Val Leu Pro His Lys Glu Leu Ser Arg Ser Phe Thr Asn 
                405                 410                 415     


Gln Ile Ile Leu 
            420 


<210>  4528
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMPPB__Homo_sapiens__NP_037466

<400>  4528

Met Lys Ala Leu Ile Leu Val Gly Gly Tyr Gly Thr Arg Leu Arg Pro 
1               5                   10                  15      


Leu Thr Leu Ser Thr Pro Lys Pro Leu Val Asp Phe Cys Asn Lys Pro 
            20                  25                  30          


Ile Leu Leu His Gln Val Glu Ala Leu Ala Ala Ala Gly Val Asp His 
        35                  40                  45              


Val Ile Leu Ala Val Ser Tyr Met Ser Gln Val Leu Glu Lys Glu Met 
    50                  55                  60                  


Lys Ala Gln Glu Gln Arg Leu Gly Ile Arg Ile Ser Met Ser His Glu 
65                  70                  75                  80  


Glu Glu Pro Leu Gly Thr Ala Gly Pro Leu Ala Leu Ala Arg Asp Leu 
                85                  90                  95      


Leu Ser Glu Thr Ala Asp Pro Phe Phe Val Leu Asn Ser Asp Val Ile 
            100                 105                 110         


Cys Asp Phe Pro Phe Gln Ala Met Val Gln Phe His Arg His His Gly 
        115                 120                 125             


Gln Glu Gly Ser Ile Leu Val Thr Lys Val Glu Glu Pro Ser Lys Tyr 
    130                 135                 140                 


Gly Val Val Val Cys Glu Ala Asp Thr Gly Arg Ile His Arg Phe Val 
145                 150                 155                 160 


Glu Lys Pro Gln Val Phe Val Ser Asn Lys Ile Asn Ala Gly Met Tyr 
                165                 170                 175     


Ile Leu Ser Pro Ala Val Leu Arg Arg Ile Gln Leu Gln Pro Thr Ser 
            180                 185                 190         


Ile Glu Lys Glu Val Phe Pro Ile Met Ala Lys Glu Gly Gln Leu Tyr 
        195                 200                 205             


Ala Met Glu Leu Gln Gly Phe Trp Met Asp Ile Gly Gln Pro Lys Asp 
    210                 215                 220                 


Phe Leu Thr Gly Met Cys Leu Phe Leu Gln Ser Leu Arg Gln Lys Gln 
225                 230                 235                 240 


Pro Glu Arg Leu Cys Ser Gly Pro Gly Ile Val Gly Asn Val Leu Val 
                245                 250                 255     


Asp Pro Ser Ala Arg Ile Gly Gln Asn Cys Ser Ile Gly Pro Asn Val 
            260                 265                 270         


Ser Leu Gly Pro Gly Val Val Val Glu Asp Gly Val Cys Ile Arg Arg 
        275                 280                 285             


Cys Thr Val Leu Arg Asp Ala Arg Ile Arg Ser His Ser Trp Leu Glu 
    290                 295                 300                 


Ser Cys Ile Val Gly Trp Arg Cys Arg Val Gly Gln Trp Val Ser Leu 
305                 310                 315                 320 


Trp Ala Gly Leu Gly Gly Glu Arg Gly Gly Glu Cys Ala Cys Leu Pro 
                325                 330                 335     


Asp Lys Ala Tyr Pro Leu Leu Glu Val Arg Met Glu Asn Val Thr Val 
            340                 345                 350         


Leu Gly Glu Asp Val Ile Val Asn Asp Glu Leu Tyr Leu Asn Gly Ala 
        355                 360                 365             


Ser Val Leu Pro His Lys Ser Ile Gly Glu Ser Val Pro Glu Pro Arg 
    370                 375                 380                 


Ile Ile Met 
385         


<210>  4529
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMPR2__Homo_sapiens__NP_001002000

<400>  4529

Met Pro His Ile Asp Asn Asp Val Lys Leu Asp Phe Lys Asp Val Leu 
1               5                   10                  15      


Leu Arg Pro Lys Arg Ser Thr Leu Lys Ser Arg Ser Glu Val Asp Leu 
            20                  25                  30          


Thr Arg Ser Phe Ser Phe Arg Asn Ser Lys Gln Thr Tyr Ser Gly Val 
        35                  40                  45              


Pro Ile Ile Ala Ala Asn Met Asp Thr Val Gly Thr Phe Glu Met Ala 
    50                  55                  60                  


Lys Val Leu Cys Lys Phe Ser Leu Phe Thr Ala Val His Lys His Tyr 
65                  70                  75                  80  


Ser Leu Val Gln Trp Gln Glu Phe Ala Gly Gln Asn Pro Asp Cys Leu 
                85                  90                  95      


Glu His Leu Ala Ala Ser Ser Gly Thr Gly Ser Ser Asp Phe Glu Gln 
            100                 105                 110         


Leu Glu Gln Ile Leu Glu Ala Ile Pro Gln Val Lys Tyr Ile Cys Leu 
        115                 120                 125             


Asp Val Ala Asn Gly Tyr Ser Glu His Phe Val Glu Phe Val Lys Asp 
    130                 135                 140                 


Val Arg Lys Arg Phe Pro Gln His Thr Ile Met Ala Gly Asn Val Val 
145                 150                 155                 160 


Thr Gly Glu Met Val Glu Glu Leu Ile Leu Ser Gly Ala Asp Ile Ile 
                165                 170                 175     


Lys Val Gly Ile Gly Pro Gly Ser Val Cys Thr Thr Arg Lys Lys Thr 
            180                 185                 190         


Gly Val Gly Tyr Pro Gln Leu Ser Ala Val Met Glu Cys Ala Asp Ala 
        195                 200                 205             


Ala His Gly Leu Lys Gly His Ile Ile Ser Asp Gly Gly Cys Ser Cys 
    210                 215                 220                 


Pro Gly Asp Val Ala Lys Ala Phe Gly Ala Gly Ala Asp Phe Val Met 
225                 230                 235                 240 


Leu Gly Gly Met Leu Ala Gly His Ser Glu Ser Gly Gly Glu Leu Ile 
                245                 250                 255     


Glu Arg Asp Gly Lys Lys Tyr Lys Leu Phe Tyr Gly Met Ser Ser Glu 
            260                 265                 270         


Met Ala Met Lys Lys Tyr Ala Gly Gly Val Ala Glu Tyr Arg Ala Ser 
        275                 280                 285             


Glu Gly Lys Thr Val Glu Val Pro Phe Lys Gly Asp Val Glu His Thr 
    290                 295                 300                 


Ile Arg Asp Ile Leu Gly Gly Ile Arg Ser Thr Cys Thr Tyr Val Gly 
305                 310                 315                 320 


Ala Ala Lys Leu Lys Glu Leu Ser Arg Arg Thr Thr Phe Ile Arg Val 
                325                 330                 335     


Thr Gln Gln Val Asn Pro Ile Phe Ser Glu Ala Cys 
            340                 345             


<210>  4530
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMPR__Homo_sapiens__NP_006868

<400>  4530

Met Pro Arg Ile Asp Ala Asp Leu Lys Leu Asp Phe Lys Asp Val Leu 
1               5                   10                  15      


Leu Arg Pro Lys Arg Ser Ser Leu Lys Ser Arg Ala Glu Val Asp Leu 
            20                  25                  30          


Glu Arg Thr Phe Thr Phe Arg Asn Ser Lys Gln Thr Tyr Ser Gly Ile 
        35                  40                  45              


Pro Ile Ile Val Ala Asn Met Asp Thr Val Gly Thr Phe Glu Met Ala 
    50                  55                  60                  


Ala Val Met Ser Gln His Ser Met Phe Thr Ala Ile His Lys His Tyr 
65                  70                  75                  80  


Ser Leu Asp Asp Trp Lys Leu Phe Ala Thr Asn His Pro Glu Cys Leu 
                85                  90                  95      


Gln Asn Val Ala Val Ser Ser Gly Ser Gly Gln Asn Asp Leu Glu Lys 
            100                 105                 110         


Met Thr Ser Ile Leu Glu Ala Val Pro Gln Val Lys Phe Ile Cys Leu 
        115                 120                 125             


Asp Val Ala Asn Gly Tyr Ser Glu His Phe Val Glu Phe Val Lys Leu 
    130                 135                 140                 


Val Arg Ala Lys Phe Pro Glu His Thr Ile Met Ala Gly Asn Val Val 
145                 150                 155                 160 


Thr Gly Glu Met Val Glu Glu Leu Ile Leu Ser Gly Ala Asp Ile Ile 
                165                 170                 175     


Lys Val Gly Val Gly Pro Gly Ser Val Cys Thr Thr Arg Thr Lys Thr 
            180                 185                 190         


Gly Val Gly Tyr Pro Gln Leu Ser Ala Val Ile Glu Cys Ala Asp Ser 
        195                 200                 205             


Ala His Gly Leu Lys Gly His Ile Ile Ser Asp Gly Gly Cys Thr Cys 
    210                 215                 220                 


Pro Gly Asp Val Ala Lys Ala Phe Gly Ala Gly Ala Asp Phe Val Met 
225                 230                 235                 240 


Leu Gly Gly Met Phe Ser Gly His Thr Glu Cys Ala Gly Glu Val Phe 
                245                 250                 255     


Glu Arg Asn Gly Arg Lys Leu Lys Leu Phe Tyr Gly Met Ser Ser Asp 
            260                 265                 270         


Thr Ala Met Asn Lys His Ala Gly Gly Val Ala Glu Tyr Arg Ala Ser 
        275                 280                 285             


Glu Gly Lys Thr Val Glu Val Pro Tyr Lys Gly Asp Val Glu Asn Thr 
    290                 295                 300                 


Ile Leu Asp Ile Leu Gly Gly Leu Arg Ser Thr Cys Thr Tyr Val Gly 
305                 310                 315                 320 


Ala Ala Lys Leu Lys Glu Leu Ser Arg Arg Ala Thr Phe Ile Arg Val 
                325                 330                 335     


Thr Gln Gln His Asn Thr Val Phe Ser 
            340                 345 


<210>  4531
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GMPS__Homo_sapiens__NP_003866

<400>  4531

Met Ala Leu Cys Asn Gly Asp Ser Lys Leu Glu Asn Ala Gly Gly Asp 
1               5                   10                  15      


Leu Lys Asp Gly His His His Tyr Glu Gly Ala Val Val Ile Leu Asp 
            20                  25                  30          


Ala Gly Ala Gln Tyr Gly Lys Val Ile Asp Arg Arg Val Arg Glu Leu 
        35                  40                  45              


Phe Val Gln Ser Glu Ile Phe Pro Leu Glu Thr Pro Ala Phe Ala Ile 
    50                  55                  60                  


Lys Glu Gln Gly Phe Arg Ala Ile Ile Ile Ser Gly Gly Pro Asn Ser 
65                  70                  75                  80  


Val Tyr Ala Glu Asp Ala Pro Trp Phe Asp Pro Ala Ile Phe Thr Ile 
                85                  90                  95      


Gly Lys Pro Val Leu Gly Ile Cys Tyr Gly Met Gln Met Met Asn Lys 
            100                 105                 110         


Val Phe Gly Gly Thr Val His Lys Lys Ser Val Arg Glu Asp Gly Val 
        115                 120                 125             


Phe Asn Ile Ser Val Asp Asn Thr Cys Ser Leu Phe Arg Gly Leu Gln 
    130                 135                 140                 


Lys Glu Glu Val Val Leu Leu Thr His Gly Asp Ser Val Asp Lys Val 
145                 150                 155                 160 


Ala Asp Gly Phe Lys Val Val Ala Arg Ser Gly Asn Ile Val Ala Gly 
                165                 170                 175     


Ile Ala Asn Glu Ser Lys Lys Leu Tyr Gly Ala Gln Phe His Pro Glu 
            180                 185                 190         


Val Gly Leu Thr Glu Asn Gly Lys Val Ile Leu Lys Asn Phe Leu Tyr 
        195                 200                 205             


Asp Ile Ala Gly Cys Ser Gly Thr Phe Thr Val Gln Asn Arg Glu Leu 
    210                 215                 220                 


Glu Cys Ile Arg Glu Ile Lys Glu Arg Val Gly Thr Ser Lys Val Leu 
225                 230                 235                 240 


Val Leu Leu Ser Gly Gly Val Asp Ser Thr Val Cys Thr Ala Leu Leu 
                245                 250                 255     


Asn Arg Ala Leu Asn Gln Glu Gln Val Ile Ala Val His Ile Asp Asn 
            260                 265                 270         


Gly Phe Met Arg Lys Arg Glu Ser Gln Ser Val Glu Glu Ala Leu Lys 
        275                 280                 285             


Lys Leu Gly Ile Gln Val Lys Val Ile Asn Ala Ala His Ser Phe Tyr 
    290                 295                 300                 


Asn Gly Thr Thr Thr Leu Pro Ile Ser Asp Glu Asp Arg Thr Pro Arg 
305                 310                 315                 320 


Lys Arg Ile Ser Lys Thr Leu Asn Met Thr Thr Ser Pro Glu Glu Lys 
                325                 330                 335     


Arg Lys Ile Ile Gly Asp Thr Phe Val Lys Ile Ala Asn Glu Val Ile 
            340                 345                 350         


Gly Glu Met Asn Leu Lys Pro Glu Glu Val Phe Leu Ala Gln Gly Thr 
        355                 360                 365             


Leu Arg Pro Asp Leu Ile Glu Ser Ala Ser Leu Val Ala Ser Gly Lys 
    370                 375                 380                 


Ala Glu Leu Ile Lys Thr His His Asn Asp Thr Glu Leu Ile Arg Lys 
385                 390                 395                 400 


Leu Arg Glu Glu Gly Lys Val Ile Glu Pro Leu Lys Asp Phe His Lys 
                405                 410                 415     


Asp Glu Val Arg Ile Leu Gly Arg Glu Leu Gly Leu Pro Glu Glu Leu 
            420                 425                 430         


Val Ser Arg His Pro Phe Pro Gly Pro Gly Leu Ala Ile Arg Val Ile 
        435                 440                 445             


Cys Ala Glu Glu Pro Tyr Ile Cys Lys Asp Phe Pro Glu Thr Asn Asn 
    450                 455                 460                 


Ile Leu Lys Ile Val Ala Asp Phe Ser Ala Ser Val Lys Lys Pro His 
465                 470                 475                 480 


Thr Leu Leu Gln Arg Val Lys Ala Cys Thr Thr Glu Glu Asp Gln Glu 
                485                 490                 495     


Lys Leu Met Gln Ile Thr Ser Leu His Ser Leu Asn Ala Phe Leu Leu 
            500                 505                 510         


Pro Ile Lys Thr Val Gly Val Gln Gly Asp Cys Arg Ser Tyr Ser Tyr 
        515                 520                 525             


Val Cys Gly Ile Ser Ser Lys Asp Glu Pro Asp Trp Glu Ser Leu Ile 
    530                 535                 540                 


Phe Leu Ala Arg Leu Ile Pro Arg Met Cys His Asn Val Asn Arg Val 
545                 550                 555                 560 


Val Tyr Ile Phe Gly Pro Pro Val Lys Glu Pro Pro Thr Asp Val Thr 
                565                 570                 575     


Pro Thr Phe Leu Thr Thr Gly Val Leu Ser Thr Leu Arg Gln Ala Asp 
            580                 585                 590         


Phe Glu Ala His Asn Ile Leu Arg Glu Ser Gly Tyr Ala Gly Lys Ile 
        595                 600                 605             


Ser Gln Met Pro Val Ile Leu Thr Pro Leu His Phe Asp Arg Asp Pro 
    610                 615                 620                 


Leu Gln Lys Gln Pro Ser Cys Gln Arg Ser Val Val Ile Arg Thr Phe 
625                 630                 635                 640 


Ile Thr Ser Asp Phe Met Thr Gly Ile Pro Ala Thr Pro Gly Asn Glu 
                645                 650                 655     


Ile Pro Val Glu Val Val Leu Lys Met Val Thr Glu Ile Lys Lys Ile 
            660                 665                 670         


Pro Gly Ile Ser Arg Ile Met Tyr Asp Leu Thr Ser Lys Pro Pro Gly 
        675                 680                 685             


Thr Thr Glu Trp Glu 
    690             


<210>  4532
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNA11__Homo_sapiens__NP_002058

<400>  4532

Met Thr Leu Glu Ser Met Met Ala Cys Cys Leu Ser Asp Glu Val Lys 
1               5                   10                  15      


Glu Ser Lys Arg Ile Asn Ala Glu Ile Glu Lys Gln Leu Arg Arg Asp 
            20                  25                  30          


Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 
        35                  40                  45              


Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 
    50                  55                  60                  


Ala Gly Tyr Ser Glu Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 
65                  70                  75                  80  


Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Glu Thr 
                85                  90                  95      


Leu Lys Ile Leu Tyr Lys Tyr Glu Gln Asn Lys Ala Asn Ala Leu Leu 
            100                 105                 110         


Ile Arg Glu Val Asp Val Glu Lys Val Thr Thr Phe Glu His Gln Tyr 
        115                 120                 125             


Val Ser Ala Ile Lys Thr Leu Trp Glu Asp Pro Gly Ile Gln Glu Cys 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr 
145                 150                 155                 160 


Leu Thr Asp Val Asp Arg Ile Ala Thr Leu Gly Tyr Leu Pro Thr Gln 
                165                 170                 175     


Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 
            180                 185                 190         


Pro Phe Asp Leu Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly 
        195                 200                 205             


Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 
    210                 215                 220                 


Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 
225                 230                 235                 240 


Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 
                245                 250                 255     


Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 
            260                 265                 270         


Leu Asn Lys Lys Asp Leu Leu Glu Asp Lys Ile Leu Tyr Ser His Leu 
        275                 280                 285             


Val Asp Tyr Phe Pro Glu Phe Asp Gly Pro Gln Arg Asp Ala Gln Ala 
    290                 295                 300                 


Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 
305                 310                 315                 320 


Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 
                325                 330                 335     


Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 
            340                 345                 350         


Leu Lys Glu Tyr Asn Leu Val 
        355                 


<210>  4533
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNA12__Homo_sapiens__NP_001269369

<400>  4533

Met Ala Pro Arg Ala Gly Leu Gly Ala Gly Pro Leu Leu Leu Arg Ser 
1               5                   10                  15      


Arg Ala Asp Trp Val Cys Gly Gly Trp Glu Ala Ala Leu Ser Ala Pro 
            20                  25                  30          


Pro Pro Phe Cys Thr Ala Trp Val Glu Arg Thr Gly Leu Val His Phe 
        35                  40                  45              


Leu Arg Glu Gly Gly His Gly Ala Cys Phe Pro Leu Ala Leu Leu His 
    50                  55                  60                  


Pro Gly Ser Val Val Ser Phe Gln Met Ile Tyr Pro Leu Ile Val Leu 
65                  70                  75                  80  


Pro Leu Cys Ala Ser Trp His Trp Gly Leu Ile Arg Lys Gly Ile Val 
                85                  90                  95      


Leu Phe Trp Gly Glu Ser Val Lys Tyr Phe Leu Asp Asn Leu Asp Arg 
            100                 105                 110         


Ile Gly Gln Leu Asn Tyr Phe Pro Ser Lys Gln Asp Ile Leu Leu Ala 
        115                 120                 125             


Arg Lys Ala Thr Lys Gly Ile Val Glu His Asp Phe Val Ile Lys Lys 
    130                 135                 140                 


Ile Pro Phe Lys Met Val Asp Val Gly Gly Gln Arg Ser Gln Arg Gln 
145                 150                 155                 160 


Lys Trp Phe Gln Cys Phe Asp Gly Ile Thr Ser Ile Leu Phe Met Val 
                165                 170                 175     


Ser Ser Ser Glu Tyr Asp Gln Val Leu Met Glu Asp Arg Arg Thr Asn 
            180                 185                 190         


Arg Leu Val Glu Ser Met Asn Ile Phe Glu Thr Ile Val Asn Asn Lys 
        195                 200                 205             


Leu Phe Phe Asn Val Ser Ile Ile Leu Phe Leu Asn Lys Met Asp Leu 
    210                 215                 220                 


Leu Val Glu Lys Val Lys Thr Val Ser Ile Lys Lys His Phe Pro Asp 
225                 230                 235                 240 


Phe Arg Gly Asp Pro His Arg Leu Glu Asp Val Gln Arg Tyr Leu Val 
                245                 250                 255     


Gln Cys Phe Asp Arg Lys Arg Arg Asn Arg Ser Lys Pro Leu Phe His 
            260                 265                 270         


His Phe Thr Thr Ala Ile Asp Thr Glu Asn Val Arg Phe Val Phe His 
        275                 280                 285             


Ala Val Lys Asp Thr Ile Leu Gln Glu Asn Leu Lys Asp Ile Met Leu 
    290                 295                 300                 


Gln 
305 


<210>  4534
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNA13__Homo_sapiens__NP_001269354

<400>  4534

Met Arg Val Leu Val Asp Ala Arg Glu Lys Leu His Ile Pro Trp Gly 
1               5                   10                  15      


Asp Asn Ser Asn Gln Gln His Gly Asp Lys Met Met Ser Phe Asp Thr 
            20                  25                  30          


Arg Ala Pro Met Ala Ala Gln Gly Met Val Glu Thr Arg Val Phe Leu 
        35                  40                  45              


Gln Tyr Leu Pro Ala Ile Arg Ala Leu Trp Ala Asp Ser Gly Ile Gln 
    50                  55                  60                  


Asn Ala Tyr Asp Arg Arg Arg Glu Phe Gln Leu Gly Glu Ser Val Lys 
65                  70                  75                  80  


Tyr Phe Leu Asp Asn Leu Asp Lys Leu Gly Glu Pro Asp Tyr Ile Pro 
                85                  90                  95      


Ser Gln Gln Asp Ile Leu Leu Ala Arg Arg Pro Thr Lys Gly Ile His 
            100                 105                 110         


Glu Tyr Asp Phe Glu Ile Lys Asn Val Pro Phe Lys Met Val Asp Val 
        115                 120                 125             


Gly Gly Gln Arg Ser Glu Arg Lys Arg Trp Phe Glu Cys Phe Asp Ser 
    130                 135                 140                 


Val Thr Ser Ile Leu Phe Leu Val Ser Ser Ser Glu Phe Asp Gln Val 
145                 150                 155                 160 


Leu Met Glu Asp Arg Leu Thr Asn Arg Leu Thr Glu Ser Leu Asn Ile 
                165                 170                 175     


Phe Glu Thr Ile Val Asn Asn Arg Val Phe Ser Asn Val Ser Ile Ile 
            180                 185                 190         


Leu Phe Leu Asn Lys Thr Asp Leu Leu Glu Glu Lys Val Gln Ile Val 
        195                 200                 205             


Ser Ile Lys Asp Tyr Phe Leu Glu Phe Glu Gly Asp Pro His Cys Leu 
    210                 215                 220                 


Arg Asp Val Gln Lys Phe Leu Val Glu Cys Phe Arg Asn Lys Arg Arg 
225                 230                 235                 240 


Asp Gln Gln Gln Lys Pro Leu Tyr His His Phe Thr Thr Ala Ile Asn 
                245                 250                 255     


Thr Glu Asn Ile Arg Leu Val Phe Arg Asp Val Lys Asp Thr Ile Leu 
            260                 265                 270         


His Asp Asn Leu Lys Gln Leu Met Leu Gln 
        275                 280         


<210>  4535
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNA14__Homo_sapiens__NP_004288

<400>  4535

Met Ala Gly Cys Cys Cys Leu Ser Ala Glu Glu Lys Glu Ser Gln Arg 
1               5                   10                  15      


Ile Ser Ala Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Lys Asp Ala 
            20                  25                  30          


Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys 
        35                  40                  45              


Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser 
    50                  55                  60                  


Asp Glu Asp Arg Lys Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe 
65                  70                  75                  80  


Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Arg Ile Gln 
                85                  90                  95      


Tyr Val Cys Glu Gln Asn Lys Glu Asn Ala Gln Ile Ile Arg Glu Val 
            100                 105                 110         


Glu Val Asp Lys Val Ser Met Leu Ser Arg Glu Gln Val Glu Ala Ile 
        115                 120                 125             


Lys Gln Leu Trp Gln Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr Leu Thr Asp Ile 
145                 150                 155                 160 


Asp Arg Ile Ala Thr Pro Ser Phe Val Pro Thr Gln Gln Asp Val Leu 
                165                 170                 175     


Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu 
            180                 185                 190         


Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Arg Lys Trp Ile His Cys Phe Glu Ser Val Thr Ser Ile Ile Phe 
    210                 215                 220                 


Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Ala Glu Cys Asp Asn 
225                 230                 235                 240 


Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Lys Thr Ile Ile Thr 
                245                 250                 255     


Tyr Pro Trp Phe Leu Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu Ile Ser Tyr Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Lys Gln Asp Val Arg Ala Ala Arg Asp Phe 
    290                 295                 300                 


Ile Leu Lys Leu Tyr Gln Asp Gln Asn Pro Asp Lys Glu Lys Val Ile 
305                 310                 315                 320 


Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Asp Asn Ile Arg Phe Val 
                325                 330                 335     


Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Arg Glu Phe 
            340                 345                 350         


Asn Leu Val 
        355 


<210>  4536
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNA15__Homo_sapiens__NP_002059

<400>  4536

Met Ala Arg Ser Leu Thr Trp Arg Cys Cys Pro Trp Cys Leu Thr Glu 
1               5                   10                  15      


Asp Glu Lys Ala Ala Ala Arg Val Asp Gln Glu Ile Asn Arg Ile Leu 
            20                  25                  30          


Leu Glu Gln Lys Lys Gln Asp Arg Gly Glu Leu Lys Leu Leu Leu Leu 
        35                  40                  45              


Gly Pro Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile 
    50                  55                  60                  


Ile His Gly Ala Gly Tyr Ser Glu Glu Glu Arg Lys Gly Phe Arg Pro 
65                  70                  75                  80  


Leu Val Tyr Gln Asn Ile Phe Val Ser Met Arg Ala Met Ile Glu Ala 
                85                  90                  95      


Met Glu Arg Leu Gln Ile Pro Phe Ser Arg Pro Glu Ser Lys His His 
            100                 105                 110         


Ala Ser Leu Val Met Ser Gln Asp Pro Tyr Lys Val Thr Thr Phe Glu 
        115                 120                 125             


Lys Arg Tyr Ala Ala Ala Met Gln Trp Leu Trp Arg Asp Ala Gly Ile 
    130                 135                 140                 


Arg Ala Cys Tyr Glu Arg Arg Arg Glu Phe His Leu Leu Asp Ser Ala 
145                 150                 155                 160 


Val Tyr Tyr Leu Ser His Leu Glu Arg Ile Thr Glu Glu Gly Tyr Val 
                165                 170                 175     


Pro Thr Ala Gln Asp Val Leu Arg Ser Arg Met Pro Thr Thr Gly Ile 
            180                 185                 190         


Asn Glu Tyr Cys Phe Ser Val Gln Lys Thr Asn Leu Arg Ile Val Asp 
        195                 200                 205             


Val Gly Gly Gln Lys Ser Glu Arg Lys Lys Trp Ile His Cys Phe Glu 
    210                 215                 220                 


Asn Val Ile Ala Leu Ile Tyr Leu Ala Ser Leu Ser Glu Tyr Asp Gln 
225                 230                 235                 240 


Cys Leu Glu Glu Asn Asn Gln Glu Asn Arg Met Lys Glu Ser Leu Ala 
                245                 250                 255     


Leu Phe Gly Thr Ile Leu Glu Leu Pro Trp Phe Lys Ser Thr Ser Val 
            260                 265                 270         


Ile Leu Phe Leu Asn Lys Thr Asp Ile Leu Glu Glu Lys Ile Pro Thr 
        275                 280                 285             


Ser His Leu Ala Thr Tyr Phe Pro Ser Phe Gln Gly Pro Lys Gln Asp 
    290                 295                 300                 


Ala Glu Ala Ala Lys Arg Phe Ile Leu Asp Met Tyr Thr Arg Met Tyr 
305                 310                 315                 320 


Thr Gly Cys Val Asp Gly Pro Glu Gly Ser Lys Lys Gly Ala Arg Ser 
                325                 330                 335     


Arg Arg Leu Phe Ser His Tyr Thr Cys Ala Thr Asp Thr Gln Asn Ile 
            340                 345                 350         


Arg Lys Val Phe Lys Asp Val Arg Asp Ser Val Leu Ala Arg Tyr Leu 
        355                 360                 365             


Asp Glu Ile Asn Leu Leu 
    370                 


<210>  4537
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAI1__Homo_sapiens__NP_001243343

<400>  4537

Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu Glu Cys Lys Gln 
1               5                   10                  15      


Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile Ile Ala Ile 
            20                  25                  30          


Ile Arg Ala Met Gly Arg Leu Lys Ile Asp Phe Gly Asp Ser Ala Arg 
        35                  40                  45              


Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ala Ala Glu Glu 
    50                  55                  60                  


Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys Arg Leu Trp Lys 
65                  70                  75                  80  


Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg Glu Tyr Gln Leu 
                85                  90                  95      


Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp Arg Ile Ala Gln 
            100                 105                 110         


Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val Lys 
        115                 120                 125             


Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu His Phe 
    130                 135                 140                 


Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
145                 150                 155                 160 


His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu Ser 
                165                 170                 175     


Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met His 
            180                 185                 190         


Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe Thr 
        195                 200                 205             


Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu Glu 
    210                 215                 220                 


Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro Glu Tyr Ala Gly 
225                 230                 235                 240 


Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys Gln Phe Glu 
                245                 250                 255     


Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe Thr 
            260                 265                 270         


Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val Thr 
        275                 280                 285             


Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu Phe 
    290                 295                 300         


<210>  4538
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAI2__Homo_sapiens__NP_001159897

<400>  4538

Met Arg Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met 
1               5                   10                  15      


Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu Glu Cys Arg Gln Tyr 
            20                  25                  30          


Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser Ile Met Ala Ile Val 
        35                  40                  45              


Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala Asp Pro Ser Arg Ala 
    50                  55                  60                  


Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Thr Ala Glu Glu Gln 
65                  70                  75                  80  


Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile Arg Arg Leu Trp Ala 
                85                  90                  95      


Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg Glu Tyr Gln Leu 
            100                 105                 110         


Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu Arg Ile Ala Gln 
        115                 120                 125             


Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val Lys 
    130                 135                 140                 


Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu His Phe 
145                 150                 155                 160 


Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
                165                 170                 175     


His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu Ser 
            180                 185                 190         


Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met His 
        195                 200                 205             


Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe Thr 
    210                 215                 220                 


Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu Glu 
225                 230                 235                 240 


Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe Pro Glu Tyr Thr Gly 
                245                 250                 255     


Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln Ser Lys Phe Glu 
            260                 265                 270         


Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe Thr 
        275                 280                 285             


Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val Thr 
    290                 295                 300                 


Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu Phe 
305                 310                 315             


<210>  4539
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAL__Homo_sapiens__NP_001248373

<400>  4539

Met Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln 
1               5                   10                  15      


Cys Phe Asn Asp Val Thr Ala Ile Ile Tyr Val Ala Ala Cys Ser Ser 
            20                  25                  30          


Tyr Asn Met Val Ile Arg Glu Asp Asn Asn Thr Asn Arg Leu Arg Glu 
        35                  40                  45              


Ser Leu Asp Leu Phe Glu Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr 
    50                  55                  60                  


Ile Ser Ile Ile Leu Phe Leu Asn Lys Gln Asp Met Leu Ala Glu Lys 
65                  70                  75                  80  


Val Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Tyr Ala 
                85                  90                  95      


Asn Tyr Thr Val Pro Glu Asp Ala Thr Pro Asp Ala Gly Glu Asp Pro 
            100                 105                 110         


Lys Val Thr Arg Ala Lys Phe Phe Ile Arg Asp Leu Phe Leu Arg Ile 
        115                 120                 125             


Ser Thr Ala Thr Gly Asp Gly Lys His Tyr Cys Tyr Pro His Phe Thr 
    130                 135                 140                 


Cys Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg 
145                 150                 155                 160 


Asp Ile Ile Gln Arg Met His Leu Lys Gln Tyr Glu Leu Leu 
                165                 170                 


<210>  4540
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAO1__Homo_sapiens__NP_066268

<400>  4540

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Phe Phe Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Gly Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Phe Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr 
305                 310                 315                 320 


Cys His Met Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  4541
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAQ__Homo_sapiens__NP_002063

<400>  4541

Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys 
1               5                   10                  15      


Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp 
            20                  25                  30          


Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly 
        35                  40                  45              


Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly 
    50                  55                  60                  


Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr 
65                  70                  75                  80  


Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr 
                85                  90                  95      


Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu 
            100                 105                 110         


Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr 
        115                 120                 125             


Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr 
145                 150                 155                 160 


Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln 
                165                 170                 175     


Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr 
            180                 185                 190         


Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly 
        195                 200                 205             


Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr 
    210                 215                 220                 


Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val 
225                 230                 235                 240 


Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg 
                245                 250                 255     


Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe 
            260                 265                 270         


Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu 
        275                 280                 285             


Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala 
    290                 295                 300                 


Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser 
305                 310                 315                 320 


Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn 
                325                 330                 335     


Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn 
            340                 345                 350         


Leu Lys Glu Tyr Asn Leu Val 
        355                 


<210>  4542
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAS__Homo_sapiens__NP_000507

<400>  4542

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                85                  90                  95      


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
            100                 105                 110         


Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
        115                 120                 125             


Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro 
    130                 135                 140                 


Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
145                 150                 155                 160 


Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
                165                 170                 175     


Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
            180                 185                 190         


Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
        195                 200                 205             


Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
    210                 215                 220                 


Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
225                 230                 235                 240 


Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val 
                245                 250                 255     


Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu 
            260                 265                 270         


Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile 
        275                 280                 285             


Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly 
    290                 295                 300                 


Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr 
305                 310                 315                 320 


Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg 
                325                 330                 335     


Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser 
            340                 345                 350         


Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
        355                 360                 365             


Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
    370                 375                 380                 


Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 


<210>  4543
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAT1__Homo_sapiens__NP_653082

<400>  4543

Met Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu 
1               5                   10                  15      


Lys Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys Leu 
            20                  25                  30          


Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln 
        35                  40                  45              


Met Lys Ile Ile His Gln Asp Gly Tyr Ser Leu Glu Glu Cys Leu Glu 
    50                  55                  60                  


Phe Ile Ala Ile Ile Tyr Gly Asn Thr Leu Gln Ser Ile Leu Ala Ile 
65                  70                  75                  80  


Val Arg Ala Met Thr Thr Leu Asn Ile Gln Tyr Gly Asp Ser Ala Arg 
                85                  90                  95      


Gln Asp Asp Ala Arg Lys Leu Met His Met Ala Asp Thr Ile Glu Glu 
            100                 105                 110         


Gly Thr Met Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys 
        115                 120                 125             


Asp Ser Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser Glu Tyr Gln Leu 
    130                 135                 140                 


Asn Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser Arg Val Lys 
                165                 170                 175     


Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys Asp Leu Asn Phe 
            180                 185                 190         


Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
        195                 200                 205             


His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Ile Ala Ala Leu Ser 
    210                 215                 220                 


Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val Asn Arg Met His 
225                 230                 235                 240 


Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala 
                245                 250                 255     


Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Phe Glu 
            260                 265                 270         


Lys Ile Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp Gly 
        275                 280                 285             


Pro Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val Gln Phe Leu 
    290                 295                 300                 


Glu Leu Asn Met Arg Arg Asp Val Lys Glu Ile Tyr Ser His Met Thr 
305                 310                 315                 320 


Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe Asp Ala Val Thr 
                325                 330                 335     


Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe 
            340                 345                 350 


<210>  4544
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAT3__Homo_sapiens__NP_001095856

<400>  4544

Met Gly Ser Gly Ile Ser Ser Glu Ser Lys Glu Ser Ala Lys Arg Ser 
1               5                   10                  15      


Lys Glu Leu Glu Lys Lys Leu Gln Glu Asp Ala Glu Arg Asp Ala Arg 
            20                  25                  30          


Thr Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Lys Asn Gly Tyr Ser Glu Gln 
    50                  55                  60                  


Glu Cys Met Glu Phe Lys Ala Val Ile Tyr Ser Asn Thr Leu Gln Ser 
65                  70                  75                  80  


Ile Leu Ala Ile Val Lys Ala Met Thr Thr Leu Gly Ile Asp Tyr Val 
                85                  90                  95      


Asn Pro Arg Ser Ala Glu Asp Gln Arg Gln Leu Tyr Ala Met Ala Asn 
            100                 105                 110         


Thr Leu Glu Asp Gly Gly Met Thr Pro Gln Leu Ala Glu Val Ile Lys 
        115                 120                 125             


Arg Leu Trp Arg Asp Pro Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp 
145                 150                 155                 160 


Arg Ile Thr Ala Ser Gly Tyr Val Pro Asn Glu Gln Asp Val Leu His 
                165                 170                 175     


Ser Arg Val Lys Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys 
            180                 185                 190         


Asp Leu His Phe Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Cys 
    210                 215                 220                 


Ala Ala Leu Ser Ala Tyr Asp Met Val Leu Val Glu Asp Glu Glu Val 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His 
                245                 250                 255     


Lys Tyr Phe Ser Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Ile Phe Gln Glu Lys Val Thr Lys Val His Leu Ser Ile Cys Phe Pro 
        275                 280                 285             


Glu Tyr Thr Gly Pro Asn Thr Phe Glu Asp Ala Gly Asn Tyr Ile Lys 
    290                 295                 300                 


Asn Gln Phe Leu Asp Leu Asn Leu Lys Lys Glu Asp Lys Glu Ile Tyr 
305                 310                 315                 320 


Ser His Met Thr Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly 
            340                 345                 350         


Leu Phe 
        


<210>  4545
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNAZ__Homo_sapiens__NP_002064

<400>  4545

Met Gly Cys Arg Gln Ser Ser Glu Glu Lys Glu Ala Ala Arg Arg Ser 
1               5                   10                  15      


Arg Arg Ile Asp Arg His Leu Arg Ser Glu Ser Gln Arg Gln Arg Arg 
            20                  25                  30          


Glu Ile Lys Leu Leu Leu Leu Gly Thr Ser Asn Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Ser Gly Gly Phe Asn Leu Glu 
    50                  55                  60                  


Ala Cys Lys Glu Tyr Lys Pro Leu Ile Ile Tyr Asn Ala Ile Asp Ser 
65                  70                  75                  80  


Leu Thr Arg Ile Ile Arg Ala Leu Ala Ala Leu Arg Ile Asp Phe His 
                85                  90                  95      


Asn Pro Asp Arg Ala Tyr Asp Ala Val Gln Leu Phe Ala Leu Thr Gly 
            100                 105                 110         


Pro Ala Glu Ser Lys Gly Glu Ile Thr Pro Glu Leu Leu Gly Val Met 
        115                 120                 125             


Arg Arg Leu Trp Ala Asp Pro Gly Ala Gln Ala Cys Phe Ser Arg Ser 
    130                 135                 140                 


Ser Glu Tyr His Leu Glu Asp Asn Ala Ala Tyr Tyr Leu Asn Asp Leu 
145                 150                 155                 160 


Glu Arg Ile Ala Ala Ala Asp Tyr Ile Pro Thr Val Glu Asp Ile Leu 
                165                 170                 175     


Arg Ser Arg Asp Met Thr Thr Gly Ile Val Glu Asn Lys Phe Thr Phe 
            180                 185                 190         


Lys Glu Leu Thr Phe Lys Met Val Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Glu Leu Ser Gly Tyr Asp Leu Lys Leu Tyr Glu Asp Asn Gln 
225                 230                 235                 240 


Thr Ser Arg Met Ala Glu Ser Leu Arg Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Asn Trp Phe Ile Asn Thr Ser Leu Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Leu Ala Glu Lys Ile Arg Arg Ile Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Lys Gly Gln Asn Thr Tyr Glu Glu Ala Ala Val Tyr Ile 
    290                 295                 300                 


Gln Arg Gln Phe Glu Asp Leu Asn Arg Asn Lys Glu Thr Lys Glu Ile 
305                 310                 315                 320 


Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Ser Asn Ile Gln Phe Val 
                325                 330                 335     


Phe Asp Ala Val Thr Asp Val Ile Ile Gln Asn Asn Leu Lys Tyr Ile 
            340                 345                 350         


Gly Leu Cys 
        355 


<210>  4546
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNB1L__Homo_sapiens__NP_443730

<400>  4546

Met Thr Ala Pro Cys Pro Pro Pro Pro Pro Asp Pro Gln Phe Val Leu 
1               5                   10                  15      


Arg Gly Thr Gln Ser Pro Val His Ala Leu His Phe Cys Glu Gly Ala 
            20                  25                  30          


Gln Ala Gln Gly Arg Pro Leu Leu Phe Ser Gly Ser Gln Ser Gly Leu 
        35                  40                  45              


Val His Ile Trp Ser Leu Gln Thr Arg Arg Ala Val Thr Thr Leu Asp 
    50                  55                  60                  


Gly His Gly Gly Gln Cys Val Thr Trp Leu Gln Thr Leu Pro Gln Gly 
65                  70                  75                  80  


Arg Gln Leu Leu Ser Gln Gly Arg Asp Leu Lys Leu Cys Leu Trp Asp 
                85                  90                  95      


Leu Ala Glu Gly Arg Ser Ala Val Val Asp Ser Val Cys Leu Glu Ser 
            100                 105                 110         


Val Gly Phe Cys Arg Ser Ser Ile Leu Ala Gly Gly Gln Pro Arg Trp 
        115                 120                 125             


Thr Leu Ala Val Pro Gly Arg Gly Ser Asp Glu Val Gln Ile Leu Glu 
    130                 135                 140                 


Met Pro Ser Lys Thr Ser Val Cys Ala Leu Lys Pro Lys Ala Asp Ala 
145                 150                 155                 160 


Lys Leu Gly Met Pro Met Cys Leu Arg Leu Trp Gln Ala Asp Cys Ser 
                165                 170                 175     


Ser Arg Pro Leu Leu Leu Ala Gly Tyr Glu Asp Gly Ser Val Val Leu 
            180                 185                 190         


Trp Asp Val Ser Glu Gln Lys Val Cys Ser Arg Ile Ala Cys His Glu 
        195                 200                 205             


Glu Pro Val Met Asp Leu Asp Phe Asp Ser Gln Lys Ala Arg Gly Ile 
    210                 215                 220                 


Ser Gly Ser Ala Gly Lys Ala Leu Ala Val Trp Ser Leu Asp Trp Gln 
225                 230                 235                 240 


Gln Ala Leu Gln Val Arg Gly Thr His Glu Leu Thr Asn Pro Gly Ile 
                245                 250                 255     


Ala Glu Val Thr Ile Arg Pro Asp Arg Lys Ile Leu Ala Thr Ala Gly 
            260                 265                 270         


Trp Asp His Arg Ile Arg Val Phe His Trp Arg Thr Met Gln Pro Leu 
        275                 280                 285             


Ala Val Leu Ala Phe His Ser Ala Ala Val Gln Cys Val Ala Phe Thr 
    290                 295                 300                 


Ala Asp Gly Leu Leu Ala Ala Gly Ser Lys Asp Gln Arg Ile Ser Leu 
305                 310                 315                 320 


Trp Ser Leu Tyr Pro Arg Ala 
                325         


<210>  4547
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNB2L1__Homo_sapiens__NP_006089

<400>  4547

Met Thr Glu Gln Met Thr Leu Arg Gly Thr Leu Lys Gly His Asn Gly 
1               5                   10                  15      


Trp Val Thr Gln Ile Ala Thr Thr Pro Gln Phe Pro Asp Met Ile Leu 
            20                  25                  30          


Ser Ala Ser Arg Asp Lys Thr Ile Ile Met Trp Lys Leu Thr Arg Asp 
        35                  40                  45              


Glu Thr Asn Tyr Gly Ile Pro Gln Arg Ala Leu Arg Gly His Ser His 
    50                  55                  60                  


Phe Val Ser Asp Val Val Ile Ser Ser Asp Gly Gln Phe Ala Leu Ser 
65                  70                  75                  80  


Gly Ser Trp Asp Gly Thr Leu Arg Leu Trp Asp Leu Thr Thr Gly Thr 
                85                  90                  95      


Thr Thr Arg Arg Phe Val Gly His Thr Lys Asp Val Leu Ser Val Ala 
            100                 105                 110         


Phe Ser Ser Asp Asn Arg Gln Ile Val Ser Gly Ser Arg Asp Lys Thr 
        115                 120                 125             


Ile Lys Leu Trp Asn Thr Leu Gly Val Cys Lys Tyr Thr Val Gln Asp 
    130                 135                 140                 


Glu Ser His Ser Glu Trp Val Ser Cys Val Arg Phe Ser Pro Asn Ser 
145                 150                 155                 160 


Ser Asn Pro Ile Ile Val Ser Cys Gly Trp Asp Lys Leu Val Lys Val 
                165                 170                 175     


Trp Asn Leu Ala Asn Cys Lys Leu Lys Thr Asn His Ile Gly His Thr 
            180                 185                 190         


Gly Tyr Leu Asn Thr Val Thr Val Ser Pro Asp Gly Ser Leu Cys Ala 
        195                 200                 205             


Ser Gly Gly Lys Asp Gly Gln Ala Met Leu Trp Asp Leu Asn Glu Gly 
    210                 215                 220                 


Lys His Leu Tyr Thr Leu Asp Gly Gly Asp Ile Ile Asn Ala Leu Cys 
225                 230                 235                 240 


Phe Ser Pro Asn Arg Tyr Trp Leu Cys Ala Ala Thr Gly Pro Ser Ile 
                245                 250                 255     


Lys Ile Trp Asp Leu Glu Gly Lys Ile Ile Val Asp Glu Leu Lys Gln 
            260                 265                 270         


Glu Val Ile Ser Thr Ser Ser Lys Ala Glu Pro Pro Gln Cys Thr Ser 
        275                 280                 285             


Leu Ala Trp Ser Ala Asp Gly Gln Thr Leu Phe Ala Gly Tyr Thr Asp 
    290                 295                 300                 


Asn Leu Val Arg Val Trp Gln Val Thr Ile Gly Thr Arg 
305                 310                 315         


<210>  4548
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNB3__Homo_sapiens__NP_002066

<400>  4548

Met Gly Glu Met Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Lys Lys 
1               5                   10                  15      


Gln Ile Ala Asp Ala Arg Lys Ala Cys Ala Asp Val Thr Leu Ala Glu 
            20                  25                  30          


Leu Val Ser Gly Leu Glu Val Val Gly Arg Val Gln Met Arg Thr Arg 
        35                  40                  45              


Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp Ala 
    50                  55                  60                  


Thr Asp Ser Lys Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu Ile 
65                  70                  75                  80  


Val Trp Asp Ser Tyr Thr Thr Asn Lys Val His Ala Ile Pro Leu Arg 
                85                  90                  95      


Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Phe Val 
            100                 105                 110         


Ala Cys Gly Gly Leu Asp Asn Met Cys Ser Ile Tyr Asn Leu Lys Ser 
        115                 120                 125             


Arg Glu Gly Asn Val Lys Val Ser Arg Glu Leu Ser Ala His Thr Gly 
    130                 135                 140                 


Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Asn Asn Ile Val Thr Ser 
145                 150                 155                 160 


Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Gly Gln Gln 
                165                 170                 175     


Lys Thr Val Phe Val Gly His Thr Gly Asp Cys Met Ser Leu Ala Val 
            180                 185                 190         


Ser Pro Asp Phe Asn Leu Phe Ile Ser Gly Ala Cys Asp Ala Ser Ala 
        195                 200                 205             


Lys Leu Trp Asp Val Arg Glu Gly Thr Cys Arg Gln Thr Phe Thr Gly 
    210                 215                 220                 


His Glu Ser Asp Ile Asn Ala Ile Cys Phe Phe Pro Asn Gly Glu Ala 
225                 230                 235                 240 


Ile Cys Thr Gly Ser Asp Asp Ala Ser Cys Arg Leu Phe Asp Leu Arg 
                245                 250                 255     


Ala Asp Gln Glu Leu Ile Cys Phe Ser His Glu Ser Ile Ile Cys Gly 
            260                 265                 270         


Ile Thr Ser Val Ala Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly 
        275                 280                 285             


Tyr Asp Asp Phe Asn Cys Asn Val Trp Asp Ser Met Lys Ser Glu Arg 
    290                 295                 300                 


Val Gly Ile Leu Ser Gly His Asp Asn Arg Val Ser Cys Leu Gly Val 
305                 310                 315                 320 


Thr Ala Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe Leu 
                325                 330                 335     


Lys Ile Trp Asn 
            340 


<210>  4549
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNB4__Homo_sapiens__XP_006713784

<400>  4549

Met Ser Glu Leu Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Arg Asn 
1               5                   10                  15      


Gln Ile Gln Asp Ala Arg Lys Ala Cys Asn Asp Ala Thr Leu Val Gln 
            20                  25                  30          


Ile Thr Ser Asn Met Asp Ser Val Gly Arg Ile Gln Met Arg Thr Arg 
        35                  40                  45              


Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp Gly 
    50                  55                  60                  


Tyr Asp Ser Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu Ile 
65                  70                  75                  80  


Ile Trp Asp Ser Tyr Thr Thr Asn Lys Met His Ala Ile Pro Leu Arg 
                85                  90                  95      


Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Tyr Val 
            100                 105                 110         


Ala Cys Gly Gly Leu Asp Asn Ile Cys Ser Ile Tyr Asn Leu Lys Thr 
        115                 120                 125             


Arg Glu Gly Asn Val Arg Val Ser Arg Glu Leu Pro Gly His Thr Gly 
    130                 135                 140                 


Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Ser Gln Ile Val Thr Ser 
145                 150                 155                 160 


Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Ala Gln Gln 
                165                 170                 175     


Thr Thr Thr Phe Thr Gly His Ser Gly Asp Val Met Ser Leu Ser Leu 
            180                 185                 190         


Ser Pro Asp Met Arg Thr Phe Val Ser Gly Ala Cys Asp Ala Ser Ser 
        195                 200                 205             


Lys Leu Trp Asp Ile Arg Asp Gly Met Cys Arg Gln Ser Phe Thr Gly 
    210                 215                 220                 


His Val Ser Asp Ile Asn Ala Val Ser Phe Phe Pro Asn Gly Tyr Ala 
225                 230                 235                 240 


Phe Ala Thr Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg 
                245                 250                 255     


Ala Asp Gln Glu Leu Leu Leu Tyr Ser His Asp Asn Ile Ile Cys Gly 
            260                 265                 270         


Ile Thr Ser Val Ala Phe Ser Lys Ser Gly Arg Leu Leu Leu Ala Gly 
        275                 280                 285             


Tyr Asp Asp Phe Asn Cys Asn Val Trp Asp Thr Leu Lys Gly Asp Arg 
    290                 295                 300                 


Ala Gly Val Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly Val 
305                 310                 315                 320 


Thr Asp Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe Leu 
                325                 330                 335     


Arg Ile Trp Asn 
            340 


<210>  4550
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNB5__Homo_sapiens__NP_006569

<400>  4550

Met Ala Thr Glu Gly Leu His Glu Asn Glu Thr Leu Ala Ser Leu Lys 
1               5                   10                  15      


Ser Glu Ala Glu Ser Leu Lys Gly Lys Leu Glu Glu Glu Arg Ala Lys 
            20                  25                  30          


Leu His Asp Val Glu Leu His Gln Val Ala Glu Arg Val Glu Ala Leu 
        35                  40                  45              


Gly Gln Phe Val Met Lys Thr Arg Arg Thr Leu Lys Gly His Gly Asn 
    50                  55                  60                  


Lys Val Leu Cys Met Asp Trp Cys Lys Asp Lys Arg Arg Ile Val Ser 
65                  70                  75                  80  


Ser Ser Gln Asp Gly Lys Val Ile Val Trp Asp Ser Phe Thr Thr Asn 
                85                  90                  95      


Lys Glu His Ala Val Thr Met Pro Cys Thr Trp Val Met Ala Cys Ala 
            100                 105                 110         


Tyr Ala Pro Ser Gly Cys Ala Ile Ala Cys Gly Gly Leu Asp Asn Lys 
        115                 120                 125             


Cys Ser Val Tyr Pro Leu Thr Phe Asp Lys Asn Glu Asn Met Ala Ala 
    130                 135                 140                 


Lys Lys Lys Ser Val Ala Met His Thr Asn Tyr Leu Ser Ala Cys Ser 
145                 150                 155                 160 


Phe Thr Asn Ser Asp Met Gln Ile Leu Thr Ala Ser Gly Asp Gly Thr 
                165                 170                 175     


Cys Ala Leu Trp Asp Val Glu Ser Gly Gln Leu Leu Gln Ser Phe His 
            180                 185                 190         


Gly His Gly Ala Asp Val Leu Cys Leu Asp Leu Ala Pro Ser Glu Thr 
        195                 200                 205             


Gly Asn Thr Phe Val Ser Gly Gly Cys Asp Lys Lys Ala Met Val Trp 
    210                 215                 220                 


Asp Met Arg Ser Gly Gln Cys Val Gln Ala Phe Glu Thr His Glu Ser 
225                 230                 235                 240 


Asp Ile Asn Ser Val Arg Tyr Tyr Pro Ser Gly Asp Ala Phe Ala Ser 
                245                 250                 255     


Gly Ser Asp Asp Ala Thr Cys Arg Leu Tyr Asp Leu Arg Ala Asp Arg 
            260                 265                 270         


Glu Val Ala Ile Tyr Ser Lys Glu Ser Ile Ile Phe Gly Ala Ser Ser 
        275                 280                 285             


Val Asp Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asn Asp 
    290                 295                 300                 


Tyr Thr Ile Asn Val Trp Asp Val Leu Lys Gly Ser Arg Val Ser Ile 
305                 310                 315                 320 


Leu Phe Gly His Glu Asn Arg Val Ser Thr Leu Arg Val Ser Pro Asp 
                325                 330                 335     


Gly Thr Ala Phe Cys Ser Gly Ser Trp Asp His Thr Leu Arg Val Trp 
            340                 345                 350         


Ala 
    


<210>  4551
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNE__Homo_sapiens__NP_001121699

<400>  4551

Met Glu Thr Tyr Gly Tyr Leu Gln Arg Glu Ser Cys Phe Gln Gly Pro 
1               5                   10                  15      


His Glu Leu Tyr Phe Lys Asn Leu Ser Lys Arg Asn Lys Gln Ile Met 
            20                  25                  30          


Glu Lys Asn Gly Asn Asn Arg Lys Leu Arg Val Cys Val Ala Thr Cys 
        35                  40                  45              


Asn Arg Ala Asp Tyr Ser Lys Leu Ala Pro Ile Met Phe Gly Ile Lys 
    50                  55                  60                  


Thr Glu Pro Glu Phe Phe Glu Leu Asp Val Val Val Leu Gly Ser His 
65                  70                  75                  80  


Leu Ile Asp Asp Tyr Gly Asn Thr Tyr Arg Met Ile Glu Gln Asp Asp 
                85                  90                  95      


Phe Asp Ile Asn Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp Glu 
            100                 105                 110         


Ala Ala Met Val Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro Asp 
        115                 120                 125             


Val Leu Asn Arg Leu Lys Pro Asp Ile Met Ile Val His Gly Asp Arg 
    130                 135                 140                 


Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile Arg 
145                 150                 155                 160 


Ile Leu His Ile Glu Gly Gly Glu Val Ser Gly Thr Ile Asp Asp Ser 
                165                 170                 175     


Ile Arg His Ala Ile Thr Lys Leu Ala His Tyr His Val Cys Cys Thr 
            180                 185                 190         


Arg Ser Ala Glu Gln His Leu Ile Ser Met Cys Glu Asp His Asp Arg 
        195                 200                 205             


Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp Lys Leu Leu Ser Ala Lys 
    210                 215                 220                 


Asn Lys Asp Tyr Met Ser Ile Ile Arg Met Trp Leu Gly Asp Asp Val 
225                 230                 235                 240 


Lys Ser Lys Asp Tyr Ile Val Ala Leu Gln His Pro Val Thr Thr Asp 
                245                 250                 255     


Ile Lys His Ser Ile Lys Met Phe Glu Leu Thr Leu Asp Ala Leu Ile 
            260                 265                 270         


Ser Phe Asn Lys Arg Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly 
        275                 280                 285             


Ser Lys Glu Met Val Arg Val Met Arg Lys Lys Gly Ile Glu His His 
    290                 295                 300                 


Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln Phe Ile Gln 
305                 310                 315                 320 


Leu Val Ala His Ala Gly Cys Met Ile Gly Asn Ser Ser Cys Gly Val 
                325                 330                 335     


Arg Glu Val Gly Ala Phe Gly Thr Pro Val Ile Asn Leu Gly Thr Arg 
            340                 345                 350         


Gln Ile Gly Arg Glu Thr Gly Glu Asn Val Leu His Val Arg Asp Ala 
        355                 360                 365             


Asp Thr Gln Asp Lys Ile Leu Gln Ala Leu His Leu Gln Phe Gly Lys 
    370                 375                 380                 


Gln Tyr Pro Cys Ser Lys Ile Tyr Gly Asp Gly Asn Ala Val Pro Arg 
385                 390                 395                 400 


Ile Leu Lys Phe Leu Lys Ser Ile Asp Leu Gln Glu Pro Leu Gln Lys 
                405                 410                 415     


Lys Phe Cys Phe Pro Pro Val Lys Glu Asn Ile Ser Gln Asp Ile Asp 
            420                 425                 430         


His Ile Leu Glu Thr Leu Ser Ala Leu Ala Val Asp Leu Gly Gly Thr 
        435                 440                 445             


Asn Leu Arg Val Ala Ile Val Ser Met Lys Gly Glu Ile Val Lys Lys 
    450                 455                 460                 


Tyr Thr Gln Phe Asn Pro Lys Thr Tyr Glu Glu Arg Ile Asn Leu Ile 
465                 470                 475                 480 


Leu Gln Met Cys Val Glu Ala Ala Ala Glu Ala Val Lys Leu Asn Cys 
                485                 490                 495     


Arg Ile Leu Gly Val Gly Ile Ser Thr Gly Gly Arg Val Asn Pro Arg 
            500                 505                 510         


Glu Gly Ile Val Leu His Ser Thr Lys Leu Ile Gln Glu Trp Asn Ser 
        515                 520                 525             


Val Asp Leu Arg Thr Pro Leu Ser Asp Thr Leu His Leu Pro Val Trp 
    530                 535                 540                 


Val Asp Asn Asp Gly Asn Cys Ala Ala Leu Ala Glu Arg Lys Phe Gly 
545                 550                 555                 560 


Gln Gly Lys Gly Leu Glu Asn Phe Val Thr Leu Ile Thr Gly Thr Gly 
                565                 570                 575     


Ile Gly Gly Gly Ile Ile His Gln His Glu Leu Ile His Gly Ser Ser 
            580                 585                 590         


Phe Cys Ala Ala Glu Leu Gly His Leu Val Val Ser Leu Asp Gly Pro 
        595                 600                 605             


Asp Cys Ser Cys Gly Ser His Gly Cys Ile Glu Ala Tyr Ala Ser Gly 
    610                 615                 620                 


Met Ala Leu Gln Arg Glu Ala Lys Lys Leu His Asp Glu Asp Leu Leu 
625                 630                 635                 640 


Leu Val Glu Gly Met Ser Val Pro Lys Asp Glu Ala Val Gly Ala Leu 
                645                 650                 655     


His Leu Ile Gln Ala Ala Lys Leu Gly Asn Ala Lys Ala Gln Ser Ile 
            660                 665                 670         


Leu Arg Thr Ala Gly Thr Ala Leu Gly Leu Gly Val Val Asn Ile Leu 
        675                 680                 685             


His Thr Met Asn Pro Ser Leu Val Ile Leu Ser Gly Val Leu Ala Ser 
    690                 695                 700                 


His Tyr Ile His Ile Val Lys Asp Val Ile Arg Gln Gln Ala Leu Ser 
705                 710                 715                 720 


Ser Val Gln Asp Val Asp Val Val Val Ser Asp Leu Val Asp Pro Ala 
                725                 730                 735     


Leu Leu Gly Ala Ala Ser Met Val Leu Asp Tyr Thr Thr Arg Arg Ile 
            740                 745                 750         


Tyr 
    


<210>  4552
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNG10__Homo_sapiens__NP_001017998

<400>  4552

Met Ser Ser Gly Ala Ser Ala Ser Ala Leu Gln Arg Leu Val Glu Gln 
1               5                   10                  15      


Leu Lys Leu Glu Ala Gly Val Glu Arg Ile Lys Val Ser Gln Ala Ala 
            20                  25                  30          


Ala Glu Leu Gln Gln Tyr Cys Met Gln Asn Ala Cys Lys Asp Ala Leu 
        35                  40                  45              


Leu Val Gly Val Pro Ala Gly Ser Asn Pro Phe Arg Glu Pro Arg Ser 
    50                  55                  60                  


Cys Ala Leu Leu 
65              


<210>  4553
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNG11__Homo_sapiens__NP_004117

<400>  4553

Met Pro Ala Leu His Ile Glu Asp Leu Pro Glu Lys Glu Lys Leu Lys 
1               5                   10                  15      


Met Glu Val Glu Gln Leu Arg Lys Glu Val Lys Leu Gln Arg Gln Gln 
            20                  25                  30          


Val Ser Lys Cys Ser Glu Glu Ile Lys Asn Tyr Ile Glu Glu Arg Ser 
        35                  40                  45              


Gly Glu Asp Pro Leu Val Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe 
    50                  55                  60                  


Lys Glu Lys Gly Ser Cys Val Ile Ser 
65                  70              


<210>  4554
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNG2__Homo_sapiens__XP_011535148

<400>  4554

Met Ala Ser Asn Asn Thr Ala Ser Ile Ala Gln Ala Arg Lys Leu Val 
1               5                   10                  15      


Glu Gln Leu Lys Met Glu Ala Asn Ile Asp Arg Ile Lys Val Ser Lys 
            20                  25                  30          


Ala Ala Ala Asp Leu Met Ala Tyr Cys Glu Ala His Ala Lys Glu Asp 
        35                  40                  45              


Pro Leu Leu Thr Pro Val Pro Ala Ser Glu Asn Pro Phe Arg Glu Lys 
    50                  55                  60                  


Lys Phe Phe Cys Ala Ile Leu 
65                  70      


<210>  4555
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNG4__Homo_sapiens__NP_004476

<400>  4555

Met Lys Glu Gly Met Ser Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala 
1               5                   10                  15      


Arg Lys Ala Val Glu Gln Leu Lys Met Glu Ala Cys Met Asp Arg Val 
            20                  25                  30          


Lys Val Ser Gln Ala Ala Ala Asp Leu Leu Ala Tyr Cys Glu Ala His 
        35                  40                  45              


Val Arg Glu Asp Pro Leu Ile Ile Pro Val Pro Ala Ser Glu Asn Pro 
    50                  55                  60                  


Phe Arg Glu Lys Lys Phe Phe Cys Thr Ile Leu 
65                  70                  75  


<210>  4556
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNG7__Homo_sapiens__NP_443079

<400>  4556

Met Ser Ala Thr Asn Asn Ile Ala Gln Ala Arg Lys Leu Val Glu Gln 
1               5                   10                  15      


Leu Arg Ile Glu Ala Gly Ile Glu Arg Ile Lys Val Ser Lys Ala Ala 
            20                  25                  30          


Ser Asp Leu Met Ser Tyr Cys Glu Gln His Ala Arg Asn Asp Pro Leu 
        35                  40                  45              


Leu Val Gly Val Pro Ala Ser Glu Asn Pro Phe Lys Asp Lys Lys Pro 
    50                  55                  60                  


Cys Ile Ile Leu 
65              


<210>  4557
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNG8__Homo_sapiens__NP_150283

<400>  4557

Met Ser Asn Asn Met Ala Lys Ile Ala Glu Ala Arg Lys Thr Val Glu 
1               5                   10                  15      


Gln Leu Lys Leu Glu Val Asn Ile Asp Arg Met Lys Val Ser Gln Ala 
            20                  25                  30          


Ala Ala Glu Leu Leu Ala Phe Cys Glu Thr His Ala Lys Asp Asp Pro 
        35                  40                  45              


Leu Val Thr Pro Val Pro Ala Ala Glu Asn Pro Phe Arg Asp Lys Arg 
    50                  55                  60                  


Leu Phe Cys Val Leu Leu 
65                  70  


<210>  4558
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNGT1__Homo_sapiens__NP_068774

<400>  4558

Met Pro Val Ile Asn Ile Glu Asp Leu Thr Glu Lys Asp Lys Leu Lys 
1               5                   10                  15      


Met Glu Val Asp Gln Leu Lys Lys Glu Val Thr Leu Glu Arg Met Leu 
            20                  25                  30          


Val Ser Lys Cys Cys Glu Glu Val Arg Asp Tyr Val Glu Glu Arg Ser 
        35                  40                  45              


Gly Glu Asp Pro Leu Val Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe 
    50                  55                  60                  


Lys Glu Leu Lys Gly Gly Cys Val Ile Ser 
65                  70                  


<210>  4559
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNGT2__Homo_sapiens__XP_006721882

<400>  4559

Met Ala Gln Asp Leu Ser Glu Lys Asp Leu Leu Lys Met Glu Val Glu 
1               5                   10                  15      


Gln Leu Lys Lys Glu Val Lys Asn Thr Arg Ile Pro Ile Ser Lys Ala 
            20                  25                  30          


Gly Lys Glu Ile Lys Glu Tyr Val Glu Ala Gln Ala Gly Asn Asp Pro 
        35                  40                  45              


Phe Leu Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly 
    50                  55                  60                  


Gly Cys Leu Ile Ser 
65                  


<210>  4560
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNL1__Homo_sapiens__NP_005266

<400>  4560

Met Pro Arg Lys Lys Pro Phe Ser Val Lys Gln Lys Lys Lys Gln Leu 
1               5                   10                  15      


Gln Asp Lys Arg Glu Arg Lys Arg Gly Leu Gln Asp Gly Leu Arg Ser 
            20                  25                  30          


Ser Ser Asn Ser Arg Ser Gly Ser Arg Glu Arg Arg Glu Glu Gln Thr 
        35                  40                  45              


Asp Thr Ser Asp Gly Glu Ser Val Thr His His Ile Arg Arg Leu Asn 
    50                  55                  60                  


Gln Gln Pro Ser Gln Gly Leu Gly Pro Arg Gly Tyr Asp Pro Asn Arg 
65                  70                  75                  80  


Tyr Arg Leu His Phe Glu Arg Asp Ser Arg Glu Glu Val Glu Arg Arg 
                85                  90                  95      


Lys Arg Ala Ala Arg Glu Gln Val Leu Gln Pro Val Ser Ala Glu Leu 
            100                 105                 110         


Leu Glu Leu Asp Ile Arg Glu Val Tyr Gln Pro Gly Ser Val Leu Asp 
        115                 120                 125             


Phe Pro Arg Arg Pro Pro Trp Ser Tyr Glu Met Ser Lys Glu Gln Leu 
    130                 135                 140                 


Met Ser Gln Glu Glu Arg Ser Phe Gln Asp Tyr Leu Gly Lys Ile His 
145                 150                 155                 160 


Gly Ala Tyr Ser Ser Glu Lys Leu Ser Tyr Phe Glu His Asn Leu Glu 
                165                 170                 175     


Thr Trp Arg Gln Leu Trp Arg Val Leu Glu Met Ser Asp Ile Val Leu 
            180                 185                 190         


Leu Ile Thr Asp Ile Arg His Pro Val Val Asn Phe Pro Pro Ala Leu 
        195                 200                 205             


Tyr Glu Tyr Val Thr Gly Glu Leu Gly Leu Ala Leu Val Leu Val Leu 
    210                 215                 220                 


Asn Lys Val Asp Leu Ala Pro Pro Ala Leu Val Val Ala Trp Lys His 
225                 230                 235                 240 


Tyr Phe His Gln His Tyr Pro Gln Leu His Val Val Leu Phe Thr Ser 
                245                 250                 255     


Phe Pro Arg Asp Pro Arg Thr Pro Gln Asp Pro Ser Ser Val Leu Lys 
            260                 265                 270         


Lys Ser Arg Arg Arg Gly Arg Gly Trp Thr Arg Ala Leu Gly Pro Glu 
        275                 280                 285             


Gln Leu Leu Arg Ala Cys Glu Ala Ile Thr Val Gly Lys Val Asp Leu 
    290                 295                 300                 


Ser Ser Trp Arg Glu Lys Ile Ala Arg Asp Val Ala Gly Ala Thr Trp 
305                 310                 315                 320 


Gly Asn Gly Ser Gly Glu Glu Glu Glu Glu Glu Asp Gly Pro Ala Val 
                325                 330                 335     


Leu Val Glu Gln Gln Thr Asp Ser Ala Met Glu Pro Thr Gly Pro Thr 
            340                 345                 350         


Gln Glu Arg Tyr Lys Asp Gly Val Val Thr Ile Gly Cys Val Gly Phe 
        355                 360                 365             


Pro Asn Val Gly Lys Ser Ser Leu Ile Asn Gly Leu Val Gly Arg Lys 
    370                 375                 380                 


Val Val Ser Val Ser Arg Thr Pro Gly His Thr Arg Tyr Phe Gln Thr 
385                 390                 395                 400 


Tyr Phe Leu Thr Pro Ser Val Lys Leu Cys Asp Cys Pro Gly Leu Ile 
                405                 410                 415     


Phe Pro Ser Leu Leu Pro Arg Gln Leu Gln Val Leu Ala Gly Ile Tyr 
            420                 425                 430         


Pro Ile Ala Gln Ile Gln Glu Pro Tyr Thr Ala Val Gly Tyr Leu Ala 
        435                 440                 445             


Ser Arg Ile Pro Val Gln Ala Leu Leu His Leu Arg His Pro Glu Ala 
    450                 455                 460                 


Glu Asp Pro Ser Ala Glu His Pro Trp Cys Ala Trp Asp Ile Cys Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Lys Arg Gly Tyr Lys Thr Ala Lys Ala Ala Arg Asn 
                485                 490                 495     


Asp Val Tyr Arg Ala Ala Asn Ser Leu Leu Arg Leu Ala Val Asp Gly 
            500                 505                 510         


Arg Leu Ser Leu Cys Phe His Pro Pro Gly Tyr Ser Glu Gln Lys Gly 
        515                 520                 525             


Thr Trp Glu Ser His Pro Glu Thr Thr Glu Leu Val Val Leu Gln Gly 
    530                 535                 540                 


Arg Val Gly Pro Ala Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Leu 
545                 550                 555                 560 


Ser Ser Ser Cys Glu Glu Glu Gly Glu Glu Asp Arg Asp Ala Asp Glu 
                565                 570                 575     


Glu Gly Glu Gly Asp Glu Glu Thr Pro Thr Ser Ala Pro Gly Ser Ser 
            580                 585                 590         


Leu Ala Gly Arg Asn Pro Tyr Ala Leu Leu Gly Glu Asp Glu Cys 
        595                 600                 605         


<210>  4561
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNL3__Homo_sapiens__NP_055181

<400>  4561

Met Lys Arg Pro Lys Leu Lys Lys Ala Ser Lys Arg Met Thr Cys His 
1               5                   10                  15      


Lys Arg Tyr Lys Ile Gln Lys Lys Val Arg Glu His His Arg Lys Leu 
            20                  25                  30          


Arg Lys Glu Ala Lys Lys Arg Gly His Lys Lys Pro Arg Lys Asp Pro 
        35                  40                  45              


Gly Val Pro Asn Ser Ala Pro Phe Lys Glu Ala Leu Leu Arg Glu Ala 
    50                  55                  60                  


Glu Leu Arg Lys Gln Arg Leu Glu Glu Leu Lys Gln Gln Gln Lys Leu 
65                  70                  75                  80  


Asp Arg Gln Lys Glu Leu Glu Lys Lys Arg Lys Leu Glu Thr Asn Pro 
                85                  90                  95      


Asp Ile Lys Pro Ser Asn Val Glu Pro Met Glu Lys Glu Phe Gly Leu 
            100                 105                 110         


Cys Lys Thr Glu Asn Lys Ala Lys Ser Gly Lys Gln Asn Ser Lys Lys 
        115                 120                 125             


Leu Tyr Cys Gln Glu Leu Lys Lys Val Ile Glu Ala Ser Asp Val Val 
    130                 135                 140                 


Leu Glu Val Leu Asp Ala Arg Asp Pro Leu Gly Cys Arg Cys Pro Gln 
145                 150                 155                 160 


Val Glu Glu Ala Ile Val Gln Ser Gly Gln Lys Lys Leu Val Leu Ile 
                165                 170                 175     


Leu Asn Lys Ser Asp Leu Val Pro Lys Glu Asn Leu Glu Ser Trp Leu 
            180                 185                 190         


Asn Tyr Leu Lys Lys Glu Leu Pro Thr Val Val Phe Arg Ala Ser Thr 
        195                 200                 205             


Lys Pro Lys Asp Lys Gly Lys Ile Thr Lys Arg Val Lys Ala Lys Lys 
    210                 215                 220                 


Asn Ala Ala Pro Phe Arg Ser Glu Val Cys Phe Gly Lys Glu Gly Leu 
225                 230                 235                 240 


Trp Lys Leu Leu Gly Gly Phe Gln Glu Thr Cys Ser Lys Ala Ile Arg 
                245                 250                 255     


Val Gly Val Ile Gly Phe Pro Asn Val Gly Lys Ser Ser Ile Ile Asn 
            260                 265                 270         


Ser Leu Lys Gln Glu Gln Met Cys Asn Val Gly Val Ser Met Gly Leu 
        275                 280                 285             


Thr Arg Ser Met Gln Val Val Pro Leu Asp Lys Gln Ile Thr Ile Ile 
    290                 295                 300                 


Asp Ser Pro Ser Phe Ile Val Ser Pro Leu Asn Ser Ser Ser Ala Leu 
305                 310                 315                 320 


Ala Leu Arg Ser Pro Ala Ser Ile Glu Val Val Lys Pro Met Glu Ala 
                325                 330                 335     


Ala Ser Ala Ile Leu Ser Gln Ala Asp Ala Arg Gln Val Val Leu Lys 
            340                 345                 350         


Tyr Thr Val Pro Gly Tyr Arg Asn Ser Leu Glu Phe Phe Thr Val Leu 
        355                 360                 365             


Ala Gln Arg Arg Gly Met His Gln Lys Gly Gly Ile Pro Asn Val Glu 
    370                 375                 380                 


Gly Ala Ala Lys Leu Leu Trp Ser Glu Trp Thr Gly Ala Ser Leu Ala 
385                 390                 395                 400 


Tyr Tyr Cys His Pro Pro Thr Ser Trp Thr Pro Pro Pro Tyr Phe Asn 
                405                 410                 415     


Glu Ser Ile Val Val Asp Met Lys Ser Gly Phe Asn Leu Glu Glu Leu 
            420                 425                 430         


Glu Lys Asn Asn Ala Gln Ser Ile Arg Ala Ile Lys Gly Pro His Leu 
        435                 440                 445             


Ala Asn Ser Ile Leu Phe Gln Ser Ser Gly Leu Thr Asn Gly Ile Ile 
    450                 455                 460                 


Glu Glu Lys Asp Ile His Glu Glu Leu Pro Lys Arg Lys Glu Arg Lys 
465                 470                 475                 480 


Gln Glu Glu Arg Glu Asp Asp Lys Asp Ser Asp Gln Glu Thr Val Asp 
                485                 490                 495     


Glu Glu Val Asp Glu Asn Ser Ser Gly Met Phe Ala Ala Glu Glu Thr 
            500                 505                 510         


Gly Glu Ala Leu Ser Glu Glu Thr Thr Ala Gly Glu Gln Ser Thr Arg 
        515                 520                 525             


Ser Phe Ile Leu Asp Lys Ile Ile Glu Glu Asp Asp Ala Tyr Asp Phe 
    530                 535                 540                 


Ser Thr Asp Tyr Val 
545                 


<210>  4562
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNL3L__Homo_sapiens__NP_061940

<400>  4562

Met Met Lys Leu Arg His Lys Asn Lys Lys Pro Gly Glu Gly Ser Lys 
1               5                   10                  15      


Gly His Lys Lys Ile Ser Trp Pro Tyr Pro Gln Pro Ala Lys Gln Asn 
            20                  25                  30          


Gly Lys Lys Ala Thr Ser Lys Val Pro Ser Ala Pro His Phe Val His 
        35                  40                  45              


Pro Asn Asp His Ala Asn Arg Glu Ala Glu Leu Lys Lys Lys Trp Val 
    50                  55                  60                  


Glu Glu Met Arg Glu Lys Gln Gln Ala Ala Arg Glu Gln Glu Arg Gln 
65                  70                  75                  80  


Lys Arg Arg Thr Ile Glu Ser Tyr Cys Gln Asp Val Leu Arg Arg Gln 
                85                  90                  95      


Glu Glu Phe Glu His Lys Glu Glu Val Leu Gln Glu Leu Asn Met Phe 
            100                 105                 110         


Pro Gln Leu Asp Asp Glu Ala Thr Arg Lys Ala Tyr Tyr Lys Glu Phe 
        115                 120                 125             


Arg Lys Val Val Glu Tyr Ser Asp Val Ile Leu Glu Val Leu Asp Ala 
    130                 135                 140                 


Arg Asp Pro Leu Gly Cys Arg Cys Phe Gln Met Glu Glu Ala Val Leu 
145                 150                 155                 160 


Arg Ala Gln Gly Asn Lys Lys Leu Val Leu Val Leu Asn Lys Ile Asp 
                165                 170                 175     


Leu Val Pro Lys Glu Val Val Glu Lys Trp Leu Asp Tyr Leu Arg Asn 
            180                 185                 190         


Glu Leu Pro Thr Val Ala Phe Lys Ala Ser Thr Gln His Gln Val Lys 
        195                 200                 205             


Asn Leu Asn Arg Cys Ser Val Pro Val Asp Gln Ala Ser Glu Ser Leu 
    210                 215                 220                 


Leu Lys Ser Lys Ala Cys Phe Gly Ala Glu Asn Leu Met Arg Val Leu 
225                 230                 235                 240 


Gly Asn Tyr Cys Arg Leu Gly Glu Val Arg Thr His Ile Arg Val Gly 
                245                 250                 255     


Val Val Gly Leu Pro Asn Val Gly Lys Ser Ser Leu Ile Asn Ser Leu 
            260                 265                 270         


Lys Arg Ser Arg Ala Cys Ser Val Gly Ala Val Pro Gly Ile Thr Lys 
        275                 280                 285             


Phe Met Gln Glu Val Tyr Leu Asp Lys Phe Ile Arg Leu Leu Asp Ala 
    290                 295                 300                 


Pro Gly Ile Val Pro Gly Pro Asn Ser Glu Val Gly Thr Ile Leu Arg 
305                 310                 315                 320 


Asn Cys Val His Val Gln Lys Leu Ala Asp Pro Val Thr Pro Val Glu 
                325                 330                 335     


Thr Ile Leu Gln Arg Cys Asn Leu Glu Glu Ile Ser Asn Tyr Tyr Gly 
            340                 345                 350         


Val Ser Gly Phe Gln Thr Thr Glu His Phe Leu Thr Ala Val Ala His 
        355                 360                 365             


Arg Leu Gly Lys Lys Lys Lys Gly Gly Leu Tyr Ser Gln Glu Gln Ala 
    370                 375                 380                 


Ala Lys Ala Val Leu Ala Asp Trp Val Ser Gly Lys Ile Ser Phe Tyr 
385                 390                 395                 400 


Ile Pro Pro Pro Ala Thr His Thr Leu Pro Thr His Leu Ser Ala Glu 
                405                 410                 415     


Ile Val Lys Glu Met Thr Glu Val Phe Asp Ile Glu Asp Thr Glu Gln 
            420                 425                 430         


Ala Asn Glu Asp Thr Met Glu Cys Leu Ala Thr Gly Glu Ser Asp Glu 
        435                 440                 445             


Leu Leu Gly Asp Thr Asp Pro Leu Glu Met Glu Ile Lys Leu Leu His 
    450                 455                 460                 


Ser Pro Met Thr Lys Ile Ala Asp Ala Ile Glu Asn Lys Thr Thr Val 
465                 470                 475                 480 


Tyr Lys Ile Gly Asp Leu Thr Gly Tyr Cys Thr Asn Pro Asn Arg His 
                485                 490                 495     


Gln Met Gly Trp Ala Lys Arg Asn Val Asp His Arg Pro Lys Ser Asn 
            500                 505                 510         


Ser Met Val Asp Val Cys Ser Val Asp Arg Arg Ser Val Leu Gln Arg 
        515                 520                 525             


Ile Met Glu Thr Asp Pro Leu Gln Gln Gly Gln Ala Leu Ala Ser Ala 
    530                 535                 540                 


Leu Lys Asn Lys Lys Lys Met Gln Lys Arg Ala Asp Lys Ile Ala Ser 
545                 550                 555                 560 


Lys Leu Ser Asp Ser Met Met Ser Ala Leu Asp Leu Ser Gly Asn Ala 
                565                 570                 575     


Asp Asp Gly Val Gly Asp 
            580         


<210>  4563
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNLY__Homo_sapiens__NP_001289687

<400>  4563

Met Ala Thr Trp Ala Leu Leu Leu Leu Ala Ala Met Leu Leu Gly Asn 
1               5                   10                  15      


Pro Gly Leu Glu Val Ser Val Ser Pro Lys Gly Lys Asn Thr Ser Gly 
            20                  25                  30          


Arg Glu Ser Gly Phe Gly Trp Ala Ile Trp Met Glu Gly Leu Val Phe 
        35                  40                  45              


Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu Ala Arg Ala His Leu Arg 
    50                  55                  60                  


Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln Glu Gly Pro Gln Gly 
65                  70                  75                  80  


Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg Asp Tyr Arg Thr Cys 
                85                  90                  95      


Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val Asp Lys Pro Thr Gln 
            100                 105                 110         


Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys Arg Thr Gly Arg Ser 
        115                 120                 125             


Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg Arg Tyr Gln Ser Arg 
    130                 135                 140                 


Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala Gln Gln Ile Cys Glu 
145                 150                 155                 160 


Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro Leu 
                165                 170         


<210>  4564
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNMT__Homo_sapiens__NP_061833

<400>  4564

Met Val Asp Ser Val Tyr Arg Thr Arg Ser Leu Gly Val Ala Ala Glu 
1               5                   10                  15      


Gly Leu Pro Asp Gln Tyr Ala Asp Gly Glu Ala Ala Arg Val Trp Gln 
            20                  25                  30          


Leu Tyr Ile Gly Asp Thr Arg Ser Arg Thr Ala Glu Tyr Lys Ala Trp 
        35                  40                  45              


Leu Leu Gly Leu Leu Arg Gln His Gly Cys Gln Arg Val Leu Asp Val 
    50                  55                  60                  


Ala Cys Gly Thr Gly Val Asp Ser Ile Met Leu Val Glu Glu Gly Phe 
65                  70                  75                  80  


Ser Val Thr Ser Val Asp Ala Ser Asp Lys Met Leu Lys Tyr Ala Leu 
                85                  90                  95      


Lys Glu Arg Trp Asn Arg Arg His Glu Pro Ala Phe Asp Lys Trp Val 
            100                 105                 110         


Ile Glu Glu Ala Asn Trp Met Thr Leu Asp Lys Asp Val Pro Gln Ser 
        115                 120                 125             


Ala Glu Gly Gly Phe Asp Ala Val Ile Cys Leu Gly Asn Ser Phe Ala 
    130                 135                 140                 


His Leu Pro Asp Cys Lys Gly Asp Gln Ser Glu His Arg Leu Ala Leu 
145                 150                 155                 160 


Lys Asn Ile Ala Ser Met Val Arg Ala Gly Gly Leu Leu Val Ile Asp 
                165                 170                 175     


His Arg Asn Tyr Asp His Ile Leu Ser Thr Gly Cys Ala Pro Pro Gly 
            180                 185                 190         


Lys Asn Ile Tyr Tyr Lys Ser Asp Leu Thr Lys Asp Val Thr Thr Ser 
        195                 200                 205             


Val Leu Ile Val Asn Asn Lys Ala His Met Val Thr Leu Asp Tyr Thr 
    210                 215                 220                 


Val Gln Val Pro Gly Ala Gly Gln Asp Gly Ser Pro Gly Leu Ser Lys 
225                 230                 235                 240 


Phe Arg Leu Ser Tyr Tyr Pro His Cys Leu Ala Ser Phe Thr Glu Leu 
                245                 250                 255     


Leu Gln Ala Ala Phe Gly Gly Lys Cys Gln His Ser Val Leu Gly Asp 
            260                 265                 270         


Phe Lys Pro Tyr Lys Pro Gly Gln Thr Tyr Ile Pro Cys Tyr Phe Ile 
        275                 280                 285             


His Val Leu Lys Arg Thr Asp 
    290                 295 


<210>  4565
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNPAT__Homo_sapiens__NP_055051

<400>  4565

Met Glu Ser Ser Ser Ser Ser Asn Ser Tyr Phe Ser Val Gly Pro Thr 
1               5                   10                  15      


Ser Pro Ser Ala Val Val Leu Leu Tyr Ser Lys Glu Leu Lys Lys Trp 
            20                  25                  30          


Asp Glu Phe Glu Asp Ile Leu Glu Glu Arg Arg His Val Ser Asp Leu 
        35                  40                  45              


Lys Phe Ala Met Lys Cys Tyr Thr Pro Leu Val Tyr Lys Gly Ile Thr 
    50                  55                  60                  


Pro Cys Lys Pro Ile Asp Ile Lys Cys Ser Val Leu Asn Ser Glu Glu 
65                  70                  75                  80  


Ile His Tyr Val Ile Lys Gln Leu Ser Lys Glu Ser Leu Gln Ser Val 
                85                  90                  95      


Asp Val Leu Arg Glu Glu Val Ser Glu Ile Leu Asp Glu Met Ser His 
            100                 105                 110         


Lys Leu Arg Leu Gly Ala Ile Arg Phe Cys Ala Phe Thr Leu Ser Lys 
        115                 120                 125             


Val Phe Lys Gln Ile Phe Ser Lys Val Cys Val Asn Glu Glu Gly Ile 
    130                 135                 140                 


Gln Lys Leu Gln Arg Ala Ile Gln Glu His Pro Val Val Leu Leu Pro 
145                 150                 155                 160 


Ser His Arg Ser Tyr Ile Asp Phe Leu Met Leu Ser Phe Leu Leu Tyr 
                165                 170                 175     


Asn Tyr Asp Leu Pro Val Pro Val Ile Ala Ala Gly Met Asp Phe Leu 
            180                 185                 190         


Gly Met Lys Met Val Gly Glu Leu Leu Arg Met Ser Gly Ala Phe Phe 
        195                 200                 205             


Met Arg Arg Thr Phe Gly Gly Asn Lys Leu Tyr Trp Ala Val Phe Ser 
    210                 215                 220                 


Glu Tyr Val Lys Thr Met Leu Arg Asn Gly Tyr Ala Pro Val Glu Phe 
225                 230                 235                 240 


Phe Leu Glu Gly Thr Arg Ser Arg Ser Ala Lys Thr Leu Thr Pro Lys 
                245                 250                 255     


Phe Gly Leu Leu Asn Ile Val Met Glu Pro Phe Phe Lys Arg Glu Val 
            260                 265                 270         


Phe Asp Thr Tyr Leu Val Pro Ile Ser Ile Ser Tyr Asp Lys Ile Leu 
        275                 280                 285             


Glu Glu Thr Leu Tyr Val Tyr Glu Leu Leu Gly Val Pro Lys Pro Lys 
    290                 295                 300                 


Glu Ser Thr Thr Gly Leu Leu Lys Ala Arg Lys Ile Leu Ser Glu Asn 
305                 310                 315                 320 


Phe Gly Ser Ile His Val Tyr Phe Gly Asp Pro Val Ser Leu Arg Ser 
                325                 330                 335     


Leu Ala Ala Gly Arg Met Ser Arg Ser Ser Tyr Asn Leu Val Pro Arg 
            340                 345                 350         


Tyr Ile Pro Gln Lys Gln Ser Glu Asp Met His Ala Phe Val Thr Glu 
        355                 360                 365             


Val Ala Tyr Lys Met Glu Leu Leu Gln Ile Glu Asn Met Val Leu Ser 
    370                 375                 380                 


Pro Trp Thr Leu Ile Val Ala Val Leu Leu Gln Asn Arg Pro Ser Met 
385                 390                 395                 400 


Asp Phe Asp Ala Leu Val Glu Lys Thr Leu Trp Leu Lys Gly Leu Thr 
                405                 410                 415     


Gln Ala Phe Gly Gly Phe Leu Ile Trp Pro Asp Asn Lys Pro Ala Glu 
            420                 425                 430         


Glu Val Val Pro Ala Ser Ile Leu Leu His Ser Asn Ile Ala Ser Leu 
        435                 440                 445             


Val Lys Asp Gln Val Ile Leu Lys Val Asp Ser Gly Asp Ser Glu Val 
    450                 455                 460                 


Val Asp Gly Leu Met Leu Gln His Ile Thr Leu Leu Met Cys Ser Ala 
465                 470                 475                 480 


Tyr Arg Asn Gln Leu Leu Asn Ile Phe Val Arg Pro Ser Leu Val Ala 
                485                 490                 495     


Val Ala Leu Gln Met Thr Pro Gly Phe Arg Lys Glu Asp Val Tyr Ser 
            500                 505                 510         


Cys Phe Arg Phe Leu Arg Asp Val Phe Ala Asp Glu Phe Ile Phe Leu 
        515                 520                 525             


Pro Gly Asn Thr Leu Lys Asp Phe Glu Glu Gly Cys Tyr Leu Leu Cys 
    530                 535                 540                 


Lys Ser Glu Ala Ile Gln Val Thr Thr Lys Asp Ile Leu Val Thr Glu 
545                 550                 555                 560 


Lys Gly Asn Thr Val Leu Glu Phe Leu Val Gly Leu Phe Lys Pro Phe 
                565                 570                 575     


Val Glu Ser Tyr Gln Ile Ile Cys Lys Tyr Leu Leu Ser Glu Glu Glu 
            580                 585                 590         


Asp His Phe Ser Glu Glu Gln Tyr Leu Ala Ala Val Arg Lys Phe Thr 
        595                 600                 605             


Ser Gln Leu Leu Asp Gln Gly Thr Ser Gln Cys Tyr Asp Val Leu Ser 
    610                 615                 620                 


Ser Asp Val Gln Lys Asn Ala Leu Ala Ala Cys Val Arg Leu Gly Val 
625                 630                 635                 640 


Val Glu Lys Lys Lys Ile Asn Asn Asn Cys Ile Phe Asn Val Asn Glu 
                645                 650                 655     


Pro Ala Thr Thr Lys Leu Glu Glu Met Leu Gly Cys Lys Thr Pro Ile 
            660                 665                 670         


Gly Lys Pro Ala Thr Ala Lys Leu 
        675                 680 


<210>  4566
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNPDA1__Homo_sapiens__XP_005268405

<400>  4566

Met Ser Ser Phe Trp Ser Asp Tyr Leu Phe Pro Phe Val Leu Trp Gly 
1               5                   10                  15      


Lys Leu Lys Thr Gln Arg Gly Ser Gln Ser Lys Asp Lys Met Lys Leu 
            20                  25                  30          


Ile Ile Leu Glu His Tyr Ser Gln Ala Ser Glu Trp Ala Ala Lys Tyr 
        35                  40                  45              


Ile Arg Asn Arg Ile Ile Gln Phe Asn Pro Gly Pro Glu Lys Tyr Phe 
    50                  55                  60                  


Thr Leu Gly Leu Pro Thr Gly Ser Thr Pro Leu Gly Cys Tyr Lys Lys 
65                  70                  75                  80  


Leu Ile Glu Tyr Tyr Lys Asn Gly Asp Leu Ser Phe Lys Tyr Val Lys 
                85                  90                  95      


Thr Phe Asn Met Asp Glu Tyr Val Gly Leu Pro Arg Asp His Pro Glu 
            100                 105                 110         


Ser Tyr His Ser Phe Met Trp Asn Asn Phe Phe Lys His Ile Asp Ile 
        115                 120                 125             


His Pro Glu Asn Thr His Ile Leu Asp Gly Asn Ala Val Asp Leu Gln 
    130                 135                 140                 


Ala Glu Cys Asp Ala Phe Glu Glu Lys Ile Lys Ala Ala Gly Gly Ile 
145                 150                 155                 160 


Glu Leu Phe Val Gly Gly Ile Gly Pro Asp Gly His Ile Ala Phe Asn 
                165                 170                 175     


Glu Pro Gly Ser Ser Leu Val Ser Arg Thr Arg Val Lys Thr Leu Ala 
            180                 185                 190         


Met Asp Thr Ile Leu Ala Asn Ala Arg Phe Phe Asp Gly Glu Leu Thr 
        195                 200                 205             


Lys Val Pro Thr Met Ala Leu Thr Val Gly Val Gly Thr Val Met Asp 
    210                 215                 220                 


Ala Arg Glu Val Met Ile Leu Ile Thr Gly Ala His Lys Ala Phe Ala 
225                 230                 235                 240 


Leu Tyr Lys Ala Ile Glu Glu Gly Val Asn His Met Trp Thr Val Ser 
                245                 250                 255     


Ala Phe Gln Gln His Pro Arg Thr Val Phe Val Cys Asp Glu Asp Ala 
            260                 265                 270         


Thr Leu Glu Leu Lys Val Lys Thr Val Lys Tyr Phe Lys Gly Leu Met 
        275                 280                 285             


Leu Val His Asn Lys Leu Val Asp Pro Leu Tyr Ser Ile Lys Glu Lys 
    290                 295                 300                 


Glu Thr Glu Lys Ser Gln Ser Ser Lys Lys Pro Tyr Ser Asp 
305                 310                 315             


<210>  4567
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNPDA2__Homo_sapiens__NP_001257809

<400>  4567

Met Arg Leu Val Ile Leu Asp Asn Tyr Asp Leu Ala Ser Glu Trp Ala 
1               5                   10                  15      


Ala Lys Tyr Ile Cys Asn Arg Ile Ile Gln Phe Lys Pro Gly Gln Asp 
            20                  25                  30          


Arg Tyr Phe Thr Leu Gly Leu Pro Thr Gly Leu Pro Arg Asn His Pro 
        35                  40                  45              


Glu Ser Tyr His Ser Tyr Met Trp Asn Asn Phe Phe Lys His Ile Asp 
    50                  55                  60                  


Ile Asp Pro Asn Asn Ala His Ile Leu Asp Gly Asn Ala Ala Asp Leu 
65                  70                  75                  80  


Gln Ala Glu Cys Asp Ala Phe Glu Asn Lys Ile Lys Glu Ala Gly Gly 
                85                  90                  95      


Ile Asp Leu Phe Val Gly Gly Ile Gly Pro Asp Gly His Ile Ala Phe 
            100                 105                 110         


Asn Glu Pro Gly Ser Ser Leu Val Ser Arg Thr Arg Leu Lys Thr Leu 
        115                 120                 125             


Ala Met Asp Thr Ile Leu Ala Asn Ala Lys Tyr Phe Asp Gly Asp Leu 
    130                 135                 140                 


Ser Lys Val Pro Thr Met Ala Leu Thr Val Gly Val Gly Thr Val Met 
145                 150                 155                 160 


Asp Ala Arg Glu Val Met Ile Leu Ile Thr Gly Ala His Lys Ala Phe 
                165                 170                 175     


Ala Leu Tyr Lys Ala Ile Glu Glu Gly Val Asn His Met Trp Thr Val 
            180                 185                 190         


Ser Ala Phe Gln Gln His Pro Arg Thr Ile Phe Val Cys Asp Glu Asp 
        195                 200                 205             


Ala Thr Leu Glu Leu Arg Val Lys Thr Val Lys Tyr Phe Lys Gly Leu 
    210                 215                 220                 


Met His Val His Asn Lys Leu Val Asp Pro Leu Phe Ser Met Lys Asp 
225                 230                 235                 240 


Gly Asn 
        


<210>  4568
<211>  1256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNPTAB__Homo_sapiens__NP_077288

<400>  4568

Met Leu Phe Lys Leu Leu Gln Arg Gln Thr Tyr Thr Cys Leu Ser His 
1               5                   10                  15      


Arg Tyr Gly Leu Tyr Val Cys Phe Leu Gly Val Val Val Thr Ile Val 
            20                  25                  30          


Ser Ala Phe Gln Phe Gly Glu Val Val Leu Glu Trp Ser Arg Asp Gln 
        35                  40                  45              


Tyr His Val Leu Phe Asp Ser Tyr Arg Asp Asn Ile Ala Gly Lys Ser 
    50                  55                  60                  


Phe Gln Asn Arg Leu Cys Leu Pro Met Pro Ile Asp Val Val Tyr Thr 
65                  70                  75                  80  


Trp Val Asn Gly Thr Asp Leu Glu Leu Leu Lys Glu Leu Gln Gln Val 
                85                  90                  95      


Arg Glu Gln Met Glu Glu Glu Gln Lys Ala Met Arg Glu Ile Leu Gly 
            100                 105                 110         


Lys Asn Thr Thr Glu Pro Thr Lys Lys Ser Glu Lys Gln Leu Glu Cys 
        115                 120                 125             


Leu Leu Thr His Cys Ile Lys Val Pro Met Leu Val Leu Asp Pro Ala 
    130                 135                 140                 


Leu Pro Ala Asn Ile Thr Leu Lys Asp Leu Pro Ser Leu Tyr Pro Ser 
145                 150                 155                 160 


Phe His Ser Ala Ser Asp Ile Phe Asn Val Ala Lys Pro Lys Asn Pro 
                165                 170                 175     


Ser Thr Asn Val Ser Val Val Val Phe Asp Ser Thr Lys Asp Val Glu 
            180                 185                 190         


Asp Ala His Ser Gly Leu Leu Lys Gly Asn Ser Arg Gln Thr Val Trp 
        195                 200                 205             


Arg Gly Tyr Leu Thr Thr Asp Lys Glu Val Pro Gly Leu Val Leu Met 
    210                 215                 220                 


Gln Asp Leu Ala Phe Leu Ser Gly Phe Pro Pro Thr Phe Lys Glu Thr 
225                 230                 235                 240 


Asn Gln Leu Lys Thr Lys Leu Pro Glu Asn Leu Ser Ser Lys Val Lys 
                245                 250                 255     


Leu Leu Gln Leu Tyr Ser Glu Ala Ser Val Ala Leu Leu Lys Leu Asn 
            260                 265                 270         


Asn Pro Lys Asp Phe Gln Glu Leu Asn Lys Gln Thr Lys Lys Asn Met 
        275                 280                 285             


Thr Ile Asp Gly Lys Glu Leu Thr Ile Ser Pro Ala Tyr Leu Leu Trp 
    290                 295                 300                 


Asp Leu Ser Ala Ile Ser Gln Ser Lys Gln Asp Glu Asp Ile Ser Ala 
305                 310                 315                 320 


Ser Arg Phe Glu Asp Asn Glu Glu Leu Arg Tyr Ser Leu Arg Ser Ile 
                325                 330                 335     


Glu Arg His Ala Pro Trp Val Arg Asn Ile Phe Ile Val Thr Asn Gly 
            340                 345                 350         


Gln Ile Pro Ser Trp Leu Asn Leu Asp Asn Pro Arg Val Thr Ile Val 
        355                 360                 365             


Thr His Gln Asp Val Phe Arg Asn Leu Ser His Leu Pro Thr Phe Ser 
    370                 375                 380                 


Ser Pro Ala Ile Glu Ser His Ile His Arg Ile Glu Gly Leu Ser Gln 
385                 390                 395                 400 


Lys Phe Ile Tyr Leu Asn Asp Asp Val Met Phe Gly Lys Asp Val Trp 
                405                 410                 415     


Pro Asp Asp Phe Tyr Ser His Ser Lys Gly Gln Lys Val Tyr Leu Thr 
            420                 425                 430         


Trp Pro Val Pro Asn Cys Ala Glu Gly Cys Pro Gly Ser Trp Ile Lys 
        435                 440                 445             


Asp Gly Tyr Cys Asp Lys Ala Cys Asn Asn Ser Ala Cys Asp Trp Asp 
    450                 455                 460                 


Gly Gly Asp Cys Ser Gly Asn Ser Gly Gly Ser Arg Tyr Ile Ala Gly 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Ser Ile Gly Val Gly Gln Pro Trp Gln Phe Gly 
                485                 490                 495     


Gly Gly Ile Asn Ser Val Ser Tyr Cys Asn Gln Gly Cys Ala Asn Ser 
            500                 505                 510         


Trp Leu Ala Asp Lys Phe Cys Asp Gln Ala Cys Asn Val Leu Ser Cys 
        515                 520                 525             


Gly Phe Asp Ala Gly Asp Cys Gly Gln Asp His Phe His Glu Leu Tyr 
    530                 535                 540                 


Lys Val Ile Leu Leu Pro Asn Gln Thr His Tyr Ile Ile Pro Lys Gly 
545                 550                 555                 560 


Glu Cys Leu Pro Tyr Phe Ser Phe Ala Glu Val Ala Lys Arg Gly Val 
                565                 570                 575     


Glu Gly Ala Tyr Ser Asp Asn Pro Ile Ile Arg His Ala Ser Ile Ala 
            580                 585                 590         


Asn Lys Trp Lys Thr Ile His Leu Ile Met His Ser Gly Met Asn Ala 
        595                 600                 605             


Thr Thr Ile His Phe Asn Leu Thr Phe Gln Asn Thr Asn Asp Glu Glu 
    610                 615                 620                 


Phe Lys Met Gln Ile Thr Val Glu Val Asp Thr Arg Glu Gly Pro Lys 
625                 630                 635                 640 


Leu Asn Ser Thr Ala Gln Lys Gly Tyr Glu Asn Leu Val Ser Pro Ile 
                645                 650                 655     


Thr Leu Leu Pro Glu Ala Glu Ile Leu Phe Glu Asp Ile Pro Lys Glu 
            660                 665                 670         


Lys Arg Phe Pro Lys Phe Lys Arg His Asp Val Asn Ser Thr Arg Arg 
        675                 680                 685             


Ala Gln Glu Glu Val Lys Ile Pro Leu Val Asn Ile Ser Leu Leu Pro 
    690                 695                 700                 


Lys Asp Ala Gln Leu Ser Leu Asn Thr Leu Asp Leu Gln Leu Glu His 
705                 710                 715                 720 


Gly Asp Ile Thr Leu Lys Gly Tyr Asn Leu Ser Lys Ser Ala Leu Leu 
                725                 730                 735     


Arg Ser Phe Leu Met Asn Ser Gln His Ala Lys Ile Lys Asn Gln Ala 
            740                 745                 750         


Ile Ile Thr Asp Glu Thr Asn Asp Ser Leu Val Ala Pro Gln Glu Lys 
        755                 760                 765             


Gln Val His Lys Ser Ile Leu Pro Asn Ser Leu Gly Val Ser Glu Arg 
    770                 775                 780                 


Leu Gln Arg Leu Thr Phe Pro Ala Val Ser Val Lys Val Asn Gly His 
785                 790                 795                 800 


Asp Gln Gly Gln Asn Pro Pro Leu Asp Leu Glu Thr Thr Ala Arg Phe 
                805                 810                 815     


Arg Val Glu Thr His Thr Gln Lys Thr Ile Gly Gly Asn Val Thr Lys 
            820                 825                 830         


Glu Lys Pro Pro Ser Leu Ile Val Pro Leu Glu Ser Gln Met Thr Lys 
        835                 840                 845             


Glu Lys Lys Ile Thr Gly Lys Glu Lys Glu Asn Ser Arg Met Glu Glu 
    850                 855                 860                 


Asn Ala Glu Asn His Ile Gly Val Thr Glu Val Leu Leu Gly Arg Lys 
865                 870                 875                 880 


Leu Gln His Tyr Thr Asp Ser Tyr Leu Gly Phe Leu Pro Trp Glu Lys 
                885                 890                 895     


Lys Lys Tyr Phe Gln Asp Leu Leu Asp Glu Glu Glu Ser Leu Lys Thr 
            900                 905                 910         


Gln Leu Ala Tyr Phe Thr Asp Ser Lys Asn Thr Gly Arg Gln Leu Lys 
        915                 920                 925             


Asp Thr Phe Ala Asp Ser Leu Arg Tyr Val Asn Lys Ile Leu Asn Ser 
    930                 935                 940                 


Lys Phe Gly Phe Thr Ser Arg Lys Val Pro Ala His Met Pro His Met 
945                 950                 955                 960 


Ile Asp Arg Ile Val Met Gln Glu Leu Gln Asp Met Phe Pro Glu Glu 
                965                 970                 975     


Phe Asp Lys Thr Ser Phe His Lys Val Arg His Ser Glu Asp Met Gln 
            980                 985                 990         


Phe Ala Phe Ser Tyr Phe Tyr Tyr  Leu Met Ser Ala Val  Gln Pro Leu 
        995                 1000                 1005             


Asn Ile  Ser Gln Val Phe Asp  Glu Val Asp Thr Asp  Gln Ser Gly 
    1010                 1015                 1020             


Val Leu  Ser Asp Arg Glu Ile  Arg Thr Leu Ala Thr  Arg Ile His 
    1025                 1030                 1035             


Glu Leu  Pro Leu Ser Leu Gln  Asp Leu Thr Gly Leu  Glu His Met 
    1040                 1045                 1050             


Leu Ile  Asn Cys Ser Lys Met  Leu Pro Ala Asp Ile  Thr Gln Leu 
    1055                 1060                 1065             


Asn Asn  Ile Pro Pro Thr Gln  Glu Ser Tyr Tyr Asp  Pro Asn Leu 
    1070                 1075                 1080             


Pro Pro  Val Thr Lys Ser Leu  Val Thr Asn Cys Lys  Pro Val Thr 
    1085                 1090                 1095             


Asp Lys  Ile His Lys Ala Tyr  Lys Asp Lys Asn Lys  Tyr Arg Phe 
    1100                 1105                 1110             


Glu Ile  Met Gly Glu Glu Glu  Ile Ala Phe Lys Met  Ile Arg Thr 
    1115                 1120                 1125             


Asn Val  Ser His Val Val Gly  Gln Leu Asp Asp Ile  Arg Lys Asn 
    1130                 1135                 1140             


Pro Arg  Lys Phe Val Cys Leu  Asn Asp Asn Ile Asp  His Asn His 
    1145                 1150                 1155             


Lys Asp  Ala Gln Thr Val Lys  Ala Val Leu Arg Asp  Phe Tyr Glu 
    1160                 1165                 1170             


Ser Met  Phe Pro Ile Pro Ser  Gln Phe Glu Leu Pro  Arg Glu Tyr 
    1175                 1180                 1185             


Arg Asn  Arg Phe Leu His Met  His Glu Leu Gln Glu  Trp Arg Ala 
    1190                 1195                 1200             


Tyr Arg  Asp Lys Leu Lys Phe  Trp Thr His Cys Val  Leu Ala Thr 
    1205                 1210                 1215             


Leu Ile  Met Phe Thr Ile Phe  Ser Phe Phe Ala Glu  Gln Leu Ile 
    1220                 1225                 1230             


Ala Leu  Lys Arg Lys Ile Phe  Pro Arg Arg Arg Ile  His Lys Glu 
    1235                 1240                 1245             


Ala Ser  Pro Asn Arg Ile Arg  Val 
    1250                 1255     


<210>  4569
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNPTG__Homo_sapiens__NP_115909

<400>  4569

Met Ala Ala Gly Leu Ala Arg Leu Leu Leu Leu Leu Gly Leu Ser Ala 
1               5                   10                  15      


Gly Gly Pro Ala Pro Ala Gly Ala Ala Lys Met Lys Val Val Glu Glu 
            20                  25                  30          


Pro Asn Ala Phe Gly Val Asn Asn Pro Phe Leu Pro Gln Ala Ser Arg 
        35                  40                  45              


Leu Gln Ala Lys Arg Asp Pro Ser Pro Val Ser Gly Pro Val His Leu 
    50                  55                  60                  


Phe Arg Leu Ser Gly Lys Cys Phe Ser Leu Val Glu Ser Thr Tyr Lys 
65                  70                  75                  80  


Tyr Glu Phe Cys Pro Phe His Asn Val Thr Gln His Glu Gln Thr Phe 
                85                  90                  95      


Arg Trp Asn Ala Tyr Ser Gly Ile Leu Gly Ile Trp His Glu Trp Glu 
            100                 105                 110         


Ile Ala Asn Asn Thr Phe Thr Gly Met Trp Met Arg Asp Gly Asp Ala 
        115                 120                 125             


Cys Arg Ser Arg Ser Arg Gln Ser Lys Val Glu Leu Ala Cys Gly Lys 
    130                 135                 140                 


Ser Asn Arg Leu Ala His Val Ser Glu Pro Ser Thr Cys Val Tyr Ala 
145                 150                 155                 160 


Leu Thr Phe Glu Thr Pro Leu Val Cys His Pro His Ala Leu Leu Val 
                165                 170                 175     


Tyr Pro Thr Leu Pro Glu Ala Leu Gln Arg Gln Trp Asp Gln Val Glu 
            180                 185                 190         


Gln Asp Leu Ala Asp Glu Leu Ile Thr Pro Gln Gly His Glu Lys Leu 
        195                 200                 205             


Leu Arg Thr Leu Phe Glu Asp Ala Gly Tyr Leu Lys Thr Pro Glu Glu 
    210                 215                 220                 


Asn Glu Pro Thr Gln Leu Glu Gly Gly Pro Asp Ser Leu Gly Phe Glu 
225                 230                 235                 240 


Thr Leu Glu Asn Cys Arg Lys Ala His Lys Glu Leu Ser Lys Glu Ile 
                245                 250                 255     


Lys Arg Leu Lys Gly Leu Leu Thr Gln His Gly Ile Pro Tyr Thr Arg 
            260                 265                 270         


Pro Thr Glu Thr Ser Asn Leu Glu His Leu Gly His Glu Thr Pro Arg 
        275                 280                 285             


Ala Lys Ser Pro Glu Gln Leu Arg Gly Asp Pro Gly Leu Arg Gly Ser 
    290                 295                 300                 


Leu 
305 


<210>  4570
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNRH1__Homo_sapiens__NP_000816

<400>  4570

Met Cys Leu Arg Met Lys Pro Ile Gln Lys Leu Leu Ala Gly Leu Ile 
1               5                   10                  15      


Leu Leu Thr Trp Cys Val Glu Gly Cys Ser Ser Gln His Trp Ser Tyr 
            20                  25                  30          


Gly Leu Arg Pro Gly Gly Lys Arg Asp Ala Glu Asn Leu Ile Asp Ser 
        35                  40                  45              


Phe Gln Glu Ile Val Lys Glu Val Gly Gln Leu Ala Glu Thr Gln Arg 
    50                  55                  60                  


Phe Glu Cys Thr Thr His Gln Pro Arg Ser Pro Leu Arg Asp Leu Lys 
65                  70                  75                  80  


Gly Ala Leu Glu Ser Leu Ile Glu Glu Glu Thr Gly Gln Lys Lys Ile 
                85                  90                  95      


<210>  4571
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNRH2__Homo_sapiens__NP_847901

<400>  4571

Met Ala Ser Ser Arg Arg Gly Leu Leu Leu Leu Leu Leu Leu Thr Ala 
1               5                   10                  15      


His Leu Gly Pro Ser Glu Ala Gln His Trp Ser His Gly Trp Tyr Pro 
            20                  25                  30          


Gly Gly Lys Arg Ala Leu Ser Ser Ala Gln Asp Pro Gln Asn Ala Leu 
        35                  40                  45              


Arg Pro Pro Ala Gly Ser Pro Val Gln Thr Ala His Gly Leu Pro Ser 
    50                  55                  60                  


Asp Ala Leu Ala Pro Leu Asp Asp Ser Met Pro Trp Glu Gly Arg Thr 
65                  70                  75                  80  


Thr Ala Gln Trp Ser Leu His Arg Lys Arg His Leu Ala Arg Thr Leu 
                85                  90                  95      


Leu Thr Ala Ala Arg Glu Pro Arg Pro Ala Pro Pro Ser Ser Asn Lys 
            100                 105                 110         


Val 
    


<210>  4572
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNRHR__Homo_sapiens__NP_000397

<400>  4572

Met Ala Asn Ser Ala Ser Pro Glu Gln Asn Gln Asn His Cys Ser Ala 
1               5                   10                  15      


Ile Asn Asn Ser Ile Pro Leu Met Gln Gly Asn Leu Pro Thr Leu Thr 
            20                  25                  30          


Leu Ser Gly Lys Ile Arg Val Thr Val Thr Phe Phe Leu Phe Leu Leu 
        35                  40                  45              


Ser Ala Thr Phe Asn Ala Ser Phe Leu Leu Lys Leu Gln Lys Trp Thr 
    50                  55                  60                  


Gln Lys Lys Glu Lys Gly Lys Lys Leu Ser Arg Met Lys Leu Leu Leu 
65                  70                  75                  80  


Lys His Leu Thr Leu Ala Asn Leu Leu Glu Thr Leu Ile Val Met Pro 
                85                  90                  95      


Leu Asp Gly Met Trp Asn Ile Thr Val Gln Trp Tyr Ala Gly Glu Leu 
            100                 105                 110         


Leu Cys Lys Val Leu Ser Tyr Leu Lys Leu Phe Ser Met Tyr Ala Pro 
        115                 120                 125             


Ala Phe Met Met Val Val Ile Ser Leu Asp Arg Ser Leu Ala Ile Thr 
    130                 135                 140                 


Arg Pro Leu Ala Leu Lys Ser Asn Ser Lys Val Gly Gln Ser Met Val 
145                 150                 155                 160 


Gly Leu Ala Trp Ile Leu Ser Ser Val Phe Ala Gly Pro Gln Leu Tyr 
                165                 170                 175     


Ile Phe Arg Met Ile His Leu Ala Asp Ser Ser Gly Gln Thr Lys Val 
            180                 185                 190         


Phe Ser Gln Cys Val Thr His Cys Ser Phe Ser Gln Trp Trp His Gln 
        195                 200                 205             


Ala Phe Tyr Asn Phe Phe Thr Phe Ser Cys Leu Phe Ile Ile Pro Leu 
    210                 215                 220                 


Phe Ile Met Leu Ile Cys Asn Ala Lys Ile Ile Phe Thr Leu Thr Arg 
225                 230                 235                 240 


Val Leu His Gln Asp Pro His Glu Leu Gln Leu Asn Gln Ser Lys Asn 
                245                 250                 255     


Asn Ile Pro Arg Ala Arg Leu Lys Thr Leu Lys Met Thr Val Ala Phe 
            260                 265                 270         


Ala Thr Ser Phe Thr Val Cys Trp Thr Pro Tyr Tyr Val Leu Gly Ile 
        275                 280                 285             


Trp Tyr Trp Phe Asp Pro Glu Met Leu Asn Arg Leu Ser Asp Pro Val 
    290                 295                 300                 


Asn His Phe Phe Phe Leu Phe Ala Phe Leu Asn Pro Cys Phe Asp Pro 
305                 310                 315                 320 


Leu Ile Tyr Gly Tyr Phe Ser Leu 
                325             


<210>  4573
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GNS__Homo_sapiens__NP_002067

<400>  4573

Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro 
1               5                   10                  15      


Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn 
        35                  40                  45              


Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met 
    50                  55                  60                  


Thr Pro Leu Lys Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr 
65                  70                  75                  80  


Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala 
                85                  90                  95      


Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His Val Val Asn Asn 
            100                 105                 110         


Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu 
        115                 120                 125             


Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr 
    130                 135                 140                 


Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly 
145                 150                 155                 160 


Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu 
                165                 170                 175     


Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala 
            180                 185                 190         


Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu 
        195                 200                 205             


Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro 
    210                 215                 220                 


Phe Phe Met Met Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala 
225                 230                 235                 240 


Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn 
                245                 250                 255     


Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln 
            260                 265                 270         


Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala 
        275                 280                 285             


Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu 
    290                 295                 300                 


Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr 
305                 310                 315                 320 


Ile Phe Tyr Thr Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu 
                325                 330                 335     


Pro Ile Asp Lys Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu 
            340                 345                 350         


Leu Val Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu 
        355                 360                 365             


Val Ala Asn Ile Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr 
    370                 375                 380                 


Asp Leu Asn Lys Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu 
385                 390                 395                 400 


Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr 
                405                 410                 415     


Gln Gly Glu Gly Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser 
            420                 425                 430         


Pro Gly Val Ser Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr 
        435                 440                 445             


Asn Asn Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu 
    450                 455                 460                 


Gln Tyr Cys Glu Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn 
465                 470                 475                 480 


Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp 
                485                 490                 495     


Pro Glu Leu Leu Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser 
            500                 505                 510         


Cys Ser Gly Pro Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr 
        515                 520                 525             


Arg Phe Asp Pro Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr 
    530                 535                 540                 


Arg Arg Phe Ser Lys His Leu Leu 
545                 550         


<210>  4574
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLGA1__Homo_sapiens__NP_002068

<400>  4574

Met Phe Ala Lys Leu Lys Lys Lys Ile Ala Glu Glu Thr Ala Val Ala 
1               5                   10                  15      


Gln Arg Pro Gly Gly Ala Thr Arg Ile Pro Arg Ser Val Ser Lys Glu 
            20                  25                  30          


Ser Val Ala Ser Met Gly Ala Asp Ser Gly Asp Asp Phe Ala Ser Asp 
        35                  40                  45              


Gly Ser Ser Ser Arg Glu Asp Leu Ser Ser Gln Leu Leu Arg Arg Asn 
    50                  55                  60                  


Glu Gln Ile Arg Lys Leu Glu Ala Arg Leu Ser Asp Tyr Ala Glu Gln 
65                  70                  75                  80  


Val Arg Asn Leu Gln Lys Ile Lys Glu Lys Leu Glu Ile Ala Leu Glu 
                85                  90                  95      


Lys His Gln Asp Ser Ser Met Arg Lys Phe Gln Glu Gln Asn Glu Thr 
            100                 105                 110         


Phe Gln Ala Asn Arg Ala Lys Met Ala Glu Gly Leu Ala Leu Ala Leu 
        115                 120                 125             


Ala Arg Lys Asp Gln Glu Trp Ser Glu Lys Met Asp Gln Leu Glu Lys 
    130                 135                 140                 


Glu Lys Asn Ile Leu Thr Ala Gln Leu Gln Glu Met Lys Asn Gln Ser 
145                 150                 155                 160 


Met Asn Leu Phe Gln Arg Arg Asp Glu Met Asp Glu Leu Glu Gly Phe 
                165                 170                 175     


Gln Gln Gln Glu Leu Ser Lys Ile Lys His Met Leu Leu Lys Lys Glu 
            180                 185                 190         


Glu Ser Leu Gly Lys Met Glu Gln Glu Leu Glu Ala Arg Thr Arg Glu 
        195                 200                 205             


Leu Ser Arg Thr Gln Glu Glu Leu Met Asn Ser Asn Gln Met Ser Ser 
    210                 215                 220                 


Asp Leu Ser Gln Lys Leu Glu Glu Leu Gln Arg His Tyr Ser Thr Leu 
225                 230                 235                 240 


Glu Glu Gln Arg Asp His Val Ile Ala Ser Lys Thr Gly Ala Glu Ser 
                245                 250                 255     


Lys Ile Thr Ala Leu Glu Gln Lys Glu Gln Glu Leu Gln Ala Leu Ile 
            260                 265                 270         


Gln Gln Leu Ser Ile Asp Leu Gln Lys Val Thr Ala Glu Thr Gln Glu 
        275                 280                 285             


Lys Glu Asp Val Ile Thr His Leu Gln Glu Lys Val Ala Ser Leu Glu 
    290                 295                 300                 


Lys Arg Leu Glu Gln Asn Leu Ser Gly Glu Glu His Val Gln Glu Leu 
305                 310                 315                 320 


Leu Lys Glu Lys Thr Leu Ala Glu Gln Asn Leu Glu Asp Thr Arg Gln 
                325                 330                 335     


Gln Leu Leu Ala Ala Arg Ser Ser Gln Ala Lys Ala Ile Asn Thr Leu 
            340                 345                 350         


Glu Thr Arg Val Arg Glu Leu Glu Gln Thr Leu Gln Ala Ser Glu Glu 
        355                 360                 365             


Gln Leu Gln Gln Ser Lys Gly Ile Val Ala Ala Gln Glu Thr Gln Ile 
    370                 375                 380                 


Gln Glu Leu Ala Ala Ala Asn Gln Glu Ser Ser His Val Gln Gln Gln 
385                 390                 395                 400 


Ala Leu Ala Leu Glu Gln Gln Phe Leu Glu Arg Thr Gln Ala Leu Glu 
                405                 410                 415     


Ala Gln Ile Val Ala Leu Glu Arg Thr Arg Ala Ala Asp Gln Thr Thr 
            420                 425                 430         


Ala Glu Gln Gly Met Arg Gln Leu Glu Gln Glu Asn Ala Ala Leu Lys 
        435                 440                 445             


Glu Cys Arg Asn Glu Tyr Glu Arg Ser Leu Gln Asn His Gln Phe Glu 
    450                 455                 460                 


Leu Lys Lys Leu Lys Glu Glu Trp Ser Gln Arg Glu Ile Val Ser Val 
465                 470                 475                 480 


Ala Met Ala Gln Ala Leu Glu Glu Val Arg Lys Gln Arg Glu Glu Phe 
                485                 490                 495     


Gln Gln Gln Ala Ala Asn Leu Thr Ala Ile Ile Asp Glu Lys Glu Gln 
            500                 505                 510         


Asn Leu Arg Glu Lys Thr Glu Val Leu Leu Gln Lys Glu Gln Glu Ile 
        515                 520                 525             


Leu Gln Leu Glu Arg Gly His Asn Ser Ala Leu Leu Gln Ile His Gln 
    530                 535                 540                 


Leu Gln Ala Glu Leu Glu Ala Leu Arg Thr Leu Lys Ala Glu Glu Ala 
545                 550                 555                 560 


Ala Val Val Ala Glu Gln Glu Asp Leu Leu Arg Leu Arg Gly Pro Leu 
                565                 570                 575     


Gln Ala Glu Ala Leu Ser Val Asn Glu Ser His Val Thr Ser Arg Ala 
            580                 585                 590         


Met Gln Asp Pro Val Phe Gln Leu Pro Thr Ala Gly Arg Thr Pro Asn 
        595                 600                 605             


Gly Glu Val Gly Ala Met Asp Leu Thr Gln Leu Gln Lys Glu Lys Gln 
    610                 615                 620                 


Asp Leu Glu Gln Gln Leu Leu Glu Lys Asn Lys Thr Ile Lys Gln Met 
625                 630                 635                 640 


Gln Gln Arg Met Leu Glu Leu Arg Lys Thr Leu Gln Lys Glu Leu Lys 
                645                 650                 655     


Ile Arg Pro Asp Asn Glu Leu Phe Glu Val Arg Glu Lys Pro Gly Pro 
            660                 665                 670         


Glu Met Ala Asn Met Ala Pro Ser Val Thr Asn Asn Thr Asp Leu Thr 
        675                 680                 685             


Asp Ala Arg Glu Ile Asn Phe Glu Tyr Leu Lys His Val Val Leu Lys 
    690                 695                 700                 


Phe Met Ser Cys Arg Glu Ser Glu Ala Phe His Leu Ile Lys Ala Val 
705                 710                 715                 720 


Ser Val Leu Leu Asn Phe Ser Gln Glu Glu Glu Asn Met Leu Lys Glu 
                725                 730                 735     


Thr Leu Glu Tyr Lys Met Ser Trp Phe Gly Ser Lys Pro Ala Pro Lys 
            740                 745                 750         


Gly Ser Ile Arg Pro Ser Ile Ser Asn Pro Arg Ile Pro Trp Ser 
        755                 760                 765         


<210>  4575
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLGA2__Homo_sapiens__NP_004477

<400>  4575

Met Trp Pro Gln Pro Arg Leu Pro Pro Arg Pro Ala Met Ser Glu Glu 
1               5                   10                  15      


Thr Arg Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys Leu Arg Glu Tyr 
            20                  25                  30          


Gln Gln Arg Asn Ser Pro Gly Val Pro Thr Gly Ala Lys Lys Lys Lys 
        35                  40                  45              


Lys Ile Lys Asn Gly Ser Asn Pro Glu Thr Thr Thr Ser Gly Gly Cys 
    50                  55                  60                  


His Ser Pro Glu Asp Thr Pro Lys Asp Asn Ala Ala Thr Leu Gln Pro 
65                  70                  75                  80  


Ser Asp Asp Thr Val Leu Pro Gly Gly Val Pro Ser Pro Gly Ala Ser 
                85                  90                  95      


Leu Thr Ser Met Ala Ala Ser Gln Asn His Asp Ala Asp Asn Val Pro 
            100                 105                 110         


Asn Leu Met Asp Glu Thr Lys Thr Phe Ser Ser Thr Glu Ser Leu Arg 
        115                 120                 125             


Gln Leu Ser Gln Gln Leu Asn Gly Leu Val Cys Glu Ser Ala Thr Cys 
    130                 135                 140                 


Val Asn Gly Glu Gly Pro Ala Ser Ser Ala Asn Leu Lys Asp Leu Glu 
145                 150                 155                 160 


Ser Arg Tyr Gln Gln Leu Ala Val Ala Leu Asp Ser Ser Tyr Val Thr 
                165                 170                 175     


Asn Lys Gln Leu Asn Ile Thr Ile Glu Lys Leu Lys Gln Gln Asn Gln 
            180                 185                 190         


Glu Ile Thr Asp Gln Leu Glu Glu Glu Lys Lys Glu Cys His Gln Lys 
        195                 200                 205             


Gln Gly Ala Leu Arg Glu Gln Leu Gln Val His Ile Gln Thr Ile Gly 
    210                 215                 220                 


Ile Leu Val Ser Glu Lys Ala Glu Leu Gln Thr Ala Leu Ala His Thr 
225                 230                 235                 240 


Gln His Ala Ala Arg Gln Lys Glu Gly Glu Ser Glu Asp Leu Ala Ser 
                245                 250                 255     


Arg Leu Gln Tyr Ser Arg Arg Arg Val Gly Glu Leu Glu Arg Ala Leu 
            260                 265                 270         


Ser Ala Val Ser Thr Gln Gln Lys Lys Ala Asp Arg Tyr Asn Lys Glu 
        275                 280                 285             


Leu Thr Lys Glu Arg Asp Ala Leu Arg Leu Glu Leu Tyr Lys Asn Thr 
    290                 295                 300                 


Gln Ser Asn Glu Asp Leu Lys Gln Glu Lys Ser Glu Leu Glu Glu Lys 
305                 310                 315                 320 


Leu Arg Val Leu Val Thr Glu Lys Ala Gly Met Gln Leu Asn Leu Glu 
                325                 330                 335     


Glu Leu Gln Lys Lys Leu Glu Met Thr Glu Leu Leu Leu Gln Gln Phe 
            340                 345                 350         


Ser Ser Arg Cys Glu Ala Pro Asp Ala Asn Gln Gln Leu Gln Gln Ala 
        355                 360                 365             


Met Glu Glu Arg Ala Gln Leu Glu Ala His Leu Gly Gln Val Met Glu 
    370                 375                 380                 


Ser Val Arg Gln Leu Gln Met Glu Arg Asp Lys Tyr Ala Glu Asn Leu 
385                 390                 395                 400 


Lys Gly Glu Ser Ala Met Trp Arg Gln Arg Met Gln Gln Met Ser Glu 
                405                 410                 415     


Gln Val His Thr Leu Arg Glu Glu Lys Glu Cys Ser Met Ser Arg Val 
            420                 425                 430         


Gln Glu Leu Glu Thr Ser Leu Ala Glu Leu Arg Asn Gln Met Ala Glu 
        435                 440                 445             


Pro Pro Pro Pro Glu Pro Pro Ala Gly Pro Ser Glu Val Glu Gln Gln 
    450                 455                 460                 


Leu Gln Ala Glu Ala Glu His Leu Arg Lys Glu Leu Glu Gly Leu Ala 
465                 470                 475                 480 


Gly Gln Leu Gln Ala Gln Val Gln Asp Asn Glu Gly Leu Ser Arg Leu 
                485                 490                 495     


Asn Arg Glu Gln Glu Glu Arg Leu Leu Glu Leu Glu Arg Ala Ala Glu 
            500                 505                 510         


Leu Trp Gly Glu Gln Ala Glu Ala Arg Arg Gln Ile Leu Glu Thr Met 
        515                 520                 525             


Gln Asn Asp Arg Thr Thr Ile Ser Arg Ala Leu Ser Gln Asn Arg Glu 
    530                 535                 540                 


Leu Lys Glu Gln Leu Ala Glu Leu Gln Ser Gly Phe Val Lys Leu Thr 
545                 550                 555                 560 


Asn Glu Asn Met Glu Ile Thr Ser Ala Leu Gln Ser Glu Gln His Val 
                565                 570                 575     


Lys Arg Glu Leu Gly Lys Lys Leu Gly Glu Leu Gln Glu Lys Leu Ser 
            580                 585                 590         


Glu Leu Lys Glu Thr Val Glu Leu Lys Ser Gln Glu Ala Gln Ser Leu 
        595                 600                 605             


Gln Gln Gln Arg Asp Gln Tyr Leu Gly His Leu Gln Gln Tyr Val Ala 
    610                 615                 620                 


Ala Tyr Gln Gln Leu Thr Ser Glu Lys Glu Val Leu His Asn Gln Leu 
625                 630                 635                 640 


Leu Leu Gln Thr Gln Leu Val Asp Gln Leu Gln Gln Gln Glu Ala Gln 
                645                 650                 655     


Gly Lys Ala Val Ala Glu Met Ala Arg Gln Glu Leu Gln Glu Thr Gln 
            660                 665                 670         


Glu Arg Leu Glu Ala Ala Thr Gln Gln Asn Gln Gln Leu Arg Ala Gln 
        675                 680                 685             


Leu Ser Leu Met Ala His Pro Gly Glu Gly Asp Gly Leu Asp Arg Glu 
    690                 695                 700                 


Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Ala Val Ala Val Pro 
705                 710                 715                 720 


Gln Pro Met Pro Ser Ile Pro Glu Asp Leu Glu Ser Arg Glu Ala Met 
                725                 730                 735     


Val Ala Phe Phe Asn Ser Ala Val Ala Ser Ala Glu Glu Glu Gln Ala 
            740                 745                 750         


Arg Leu Arg Gly Gln Leu Lys Glu Gln Arg Val Arg Cys Arg Arg Leu 
        755                 760                 765             


Ala His Leu Leu Ala Ser Ala Gln Lys Glu Pro Glu Ala Ala Ala Pro 
    770                 775                 780                 


Ala Pro Gly Thr Gly Gly Asp Ser Val Cys Gly Glu Thr His Arg Ala 
785                 790                 795                 800 


Leu Gln Gly Ala Met Glu Lys Leu Gln Ser Arg Phe Met Glu Leu Met 
                805                 810                 815     


Gln Glu Lys Ala Asp Leu Lys Glu Arg Val Glu Glu Leu Glu His Arg 
            820                 825                 830         


Cys Ile Gln Leu Ser Gly Glu Thr Asp Thr Ile Gly Glu Tyr Ile Ala 
        835                 840                 845             


Leu Tyr Gln Ser Gln Arg Ala Val Leu Lys Glu Arg His Arg Glu Lys 
    850                 855                 860                 


Glu Glu Tyr Ile Ser Arg Leu Ala Gln Asp Lys Glu Glu Met Lys Val 
865                 870                 875                 880 


Lys Leu Leu Glu Leu Gln Glu Leu Val Leu Arg Leu Val Gly Asp Arg 
                885                 890                 895     


Asn Glu Trp His Gly Arg Phe Leu Ala Ala Ala Gln Asn Pro Ala Asp 
            900                 905                 910         


Glu Pro Thr Ser Gly Ala Pro Ala Pro Gln Glu Leu Gly Ala Ala Asn 
        915                 920                 925             


Gln Gln Gly Asp Leu Cys Glu Val Ser Leu Ala Gly Ser Val Glu Pro 
    930                 935                 940                 


Ala Gln Gly Glu Ala Arg Glu Gly Ser Pro Arg Asp Asn Pro Thr Ala 
945                 950                 955                 960 


Gln Gln Ile Met Gln Leu Leu Arg Glu Met Gln Asn Pro Arg Glu Arg 
                965                 970                 975     


Pro Gly Leu Gly Ser Asn Pro Cys Ile Pro Phe Phe Tyr Arg Ala Asp 
            980                 985                 990         


Glu Asn Asp Glu Val Lys Ile Thr  Val Ile 
        995                 1000         


<210>  4576
<211>  1134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLGA3__Homo_sapiens__NP_001166028

<400>  4576

Met Asp Gly Ala Ser Ala Glu Gln Asp Gly Leu Gln Glu Asp Arg Ser 
1               5                   10                  15      


His Ser Gly Pro Ser Ser Leu Pro Glu Ala Pro Leu Lys Pro Pro Gly 
            20                  25                  30          


Pro Leu Val Pro Pro Asp Gln Gln Asp Lys Val Gln Cys Ala Glu Val 
        35                  40                  45              


Asn Arg Ala Ser Thr Glu Gly Glu Ser Pro Asp Gly Pro Gly Gln Gly 
    50                  55                  60                  


Gly Leu Cys Gln Asn Gly Pro Thr Pro Pro Phe Pro Asp Pro Pro Ser 
65                  70                  75                  80  


Ser Leu Asp Pro Thr Thr Ser Pro Val Gly Pro Asp Ala Ser Pro Gly 
                85                  90                  95      


Val Ala Gly Phe His Asp Asn Leu Arg Lys Ser Gln Gly Thr Ser Ala 
            100                 105                 110         


Glu Gly Ser Val Arg Lys Glu Ala Leu Gln Ser Leu Arg Leu Ser Leu 
        115                 120                 125             


Pro Met Gln Glu Thr Gln Leu Cys Ser Thr Asp Ser Pro Leu Pro Leu 
    130                 135                 140                 


Glu Lys Glu Glu Gln Val Arg Leu Gln Ala Arg Lys Trp Leu Glu Glu 
145                 150                 155                 160 


Gln Leu Lys Gln Tyr Arg Val Lys Arg Gln Gln Glu Arg Ser Ser Gln 
                165                 170                 175     


Pro Ala Thr Lys Thr Arg Leu Phe Ser Thr Leu Asp Pro Glu Leu Met 
            180                 185                 190         


Leu Asn Pro Glu Asn Leu Pro Arg Ala Ser Thr Leu Ala Met Thr Lys 
        195                 200                 205             


Glu Tyr Ser Phe Leu Arg Thr Ser Val Pro Arg Gly Pro Lys Val Gly 
    210                 215                 220                 


Ser Leu Gly Leu Pro Ala His Pro Arg Glu Lys Lys Thr Ser Lys Ser 
225                 230                 235                 240 


Ser Lys Ile Arg Ser Leu Ala Asp Tyr Arg Thr Glu Asp Ser Asn Ala 
                245                 250                 255     


Gly Asn Ser Gly Gly Asn Val Pro Ala Pro Asp Ser Thr Lys Gly Ser 
            260                 265                 270         


Leu Lys Gln Asn Arg Ser Ser Ala Ala Ser Val Val Ser Glu Ile Ser 
        275                 280                 285             


Leu Ser Pro Asp Thr Asp Asp Arg Leu Glu Asn Thr Ser Leu Ala Gly 
    290                 295                 300                 


Asp Ser Val Ser Glu Val Asp Gly Asn Asp Ser Asp Ser Ser Ser Tyr 
305                 310                 315                 320 


Ser Ser Ala Ser Thr Arg Gly Thr Tyr Gly Ile Leu Ser Lys Thr Val 
                325                 330                 335     


Gly Thr Gln Asp Thr Pro Tyr Met Val Asn Gly Gln Glu Ile Pro Ala 
            340                 345                 350         


Asp Thr Leu Gly Gln Phe Pro Ser Ile Lys Asp Val Leu Gln Ala Ala 
        355                 360                 365             


Ala Ala Glu His Gln Asp Gln Gly Gln Glu Val Asn Gly Glu Val Arg 
    370                 375                 380                 


Ser Arg Arg Asp Ser Ile Cys Ser Ser Val Ser Leu Glu Ser Ser Ala 
385                 390                 395                 400 


Ala Glu Thr Gln Glu Glu Met Leu Gln Val Leu Lys Glu Lys Met Arg 
                405                 410                 415     


Leu Glu Gly Gln Leu Glu Ala Leu Ser Leu Glu Ala Ser Gln Ala Leu 
            420                 425                 430         


Lys Glu Lys Ala Glu Leu Gln Ala Gln Leu Ala Ala Leu Ser Thr Lys 
        435                 440                 445             


Leu Gln Ala Gln Val Glu Cys Ser His Ser Ser Gln Gln Arg Gln Asp 
    450                 455                 460                 


Ser Leu Ser Ser Glu Val Asp Thr Leu Lys Gln Ser Cys Trp Asp Leu 
465                 470                 475                 480 


Glu Arg Ala Met Thr Asp Leu Gln Asn Met Leu Glu Ala Lys Asn Ala 
                485                 490                 495     


Ser Leu Ala Ser Ser Asn Asn Asp Leu Gln Val Ala Glu Glu Gln Tyr 
            500                 505                 510         


Gln Arg Leu Met Ala Lys Val Glu Asp Met Gln Arg Ser Met Leu Ser 
        515                 520                 525             


Lys Asp Asn Thr Val His Asp Leu Arg Gln Gln Met Thr Ala Leu Gln 
    530                 535                 540                 


Ser Gln Leu Gln Gln Val Gln Leu Glu Arg Thr Thr Leu Thr Ser Lys 
545                 550                 555                 560 


Leu Lys Ala Ser Gln Ala Glu Ile Ser Ser Leu Gln Ser Val Arg Gln 
                565                 570                 575     


Trp Tyr Gln Gln Gln Leu Ala Leu Ala Gln Glu Ala Arg Val Arg Leu 
            580                 585                 590         


Gln Gly Glu Met Ala His Ile Gln Val Gly Gln Met Thr Gln Ala Gly 
        595                 600                 605             


Leu Leu Glu His Leu Lys Leu Glu Asn Val Ser Leu Ser Gln Gln Leu 
    610                 615                 620                 


Thr Glu Thr Gln His Arg Ser Met Lys Glu Lys Gly Arg Ile Ala Ala 
625                 630                 635                 640 


Gln Leu Gln Gly Ile Glu Ala Asp Met Leu Asp Gln Glu Ala Ala Phe 
                645                 650                 655     


Met Gln Ile Gln Glu Ala Lys Thr Met Val Glu Glu Asp Leu Gln Arg 
            660                 665                 670         


Arg Leu Glu Glu Phe Glu Gly Glu Arg Glu Arg Leu Gln Arg Met Ala 
        675                 680                 685             


Asp Ser Ala Ala Ser Leu Glu Gln Gln Leu Glu Gln Val Lys Leu Thr 
    690                 695                 700                 


Leu Leu Gln Arg Asp Gln Gln Leu Glu Ala Leu Gln Gln Glu His Leu 
705                 710                 715                 720 


Asp Leu Met Lys Gln Leu Thr Leu Thr Gln Glu Ala Leu Gln Ser Arg 
                725                 730                 735     


Glu Gln Ser Leu Asp Ala Leu Gln Thr His Tyr Asp Glu Leu Gln Ala 
            740                 745                 750         


Arg Leu Gly Glu Leu Gln Gly Glu Ala Ala Ser Arg Glu Asp Thr Ile 
        755                 760                 765             


Cys Leu Leu Gln Asn Glu Lys Ile Ile Leu Glu Ala Ala Leu Gln Ala 
    770                 775                 780                 


Ala Lys Ser Gly Lys Glu Glu Leu Asp Arg Gly Ala Arg Arg Leu Glu 
785                 790                 795                 800 


Glu Gly Thr Glu Glu Thr Ser Glu Thr Leu Glu Lys Leu Arg Glu Glu 
                805                 810                 815     


Leu Ala Ile Lys Ser Gly Gln Val Glu His Leu Gln Gln Glu Thr Ala 
            820                 825                 830         


Ala Leu Lys Lys Gln Met Gln Lys Ile Lys Glu Gln Phe Leu Gln Gln 
        835                 840                 845             


Lys Val Met Val Glu Ala Tyr Arg Arg Asp Ala Thr Ser Lys Asp Gln 
    850                 855                 860                 


Leu Ile Ser Glu Leu Lys Ala Thr Arg Lys Arg Leu Asp Ser Glu Leu 
865                 870                 875                 880 


Lys Glu Leu Arg Gln Glu Leu Met Gln Val His Gly Glu Lys Arg Thr 
                885                 890                 895     


Ala Glu Ala Glu Leu Ser Arg Leu His Arg Glu Val Ala Gln Val Arg 
            900                 905                 910         


Gln His Met Ala Asp Leu Glu Gly His Leu Gln Ser Ala Gln Lys Glu 
        915                 920                 925             


Arg Asp Glu Met Glu Thr His Leu Gln Ser Leu Gln Phe Asp Lys Glu 
    930                 935                 940                 


Gln Met Val Ala Val Thr Glu Ala Asn Glu Ala Leu Lys Lys Gln Ile 
945                 950                 955                 960 


Glu Glu Leu Gln Gln Glu Ala Arg Lys Ala Ile Thr Glu Gln Lys Gln 
                965                 970                 975     


Lys Met Arg Arg Leu Gly Ser Asp Leu Thr Ser Ala Gln Lys Glu Met 
            980                 985                 990         


Lys Thr Lys His Lys Ala Tyr Glu  Asn Ala Val Gly Ile  Leu Ser Arg 
        995                 1000                 1005             


Arg Leu  Gln Glu Ala Leu Ala  Ala Lys Glu Ala Ala  Asp Ala Glu 
    1010                 1015                 1020             


Leu Gly  Gln Leu Arg Ala Gln  Gly Gly Ser Ser Asp  Ser Ser Leu 
    1025                 1030                 1035             


Ala Leu  His Glu Arg Ile Gln  Ala Leu Glu Ala Glu  Leu Gln Ala 
    1040                 1045                 1050             


Val Ser  His Ser Lys Thr Leu  Leu Glu Lys Glu Leu  Gln Glu Val 
    1055                 1060                 1065             


Ile Ala  Leu Thr Ser Gln Glu  Leu Glu Glu Ser Arg  Glu Lys Val 
    1070                 1075                 1080             


Leu Glu  Leu Glu Asp Glu Val  Arg Pro Gly His Leu  Leu Trp Arg 
    1085                 1090                 1095             


Gln Arg  Gly Ala Gly His Val  Ser Pro Gly His Ala  Ala Thr Arg 
    1100                 1105                 1110             


Glu Thr  Arg Arg Thr Lys Leu  His Arg Val Pro Ser  Val Ala Thr 
    1115                 1120                 1125             


Phe Gly  Val Ala Thr Phe 
    1130                 


<210>  4577
<211>  2243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLGA4__Homo_sapiens__NP_001166184

<400>  4577

Met Phe Lys Lys Leu Lys Gln Lys Ile Ser Glu Glu Gln Gln Gln Leu 
1               5                   10                  15      


Gln Gln Ala Leu Ala Pro Ala Gln Ala Ser Ser Asn Ser Ser Thr Pro 
            20                  25                  30          


Thr Arg Met Arg Ser Arg Thr Ser Ser Phe Thr Glu Gln Leu Asp Glu 
        35                  40                  45              


Gly Thr Pro Asn Arg Glu Asn Ala Ser Thr His Ala Ser Lys Ser Pro 
    50                  55                  60                  


Asp Ser Val Asn Gly Ser Glu Pro Ser Ile Pro Gln Ser Gly Asp Thr 
65                  70                  75                  80  


Gln Ser Phe Ala Gln Lys Leu Gln Leu Arg Val Pro Ser Val Glu Ser 
                85                  90                  95      


Leu Phe Arg Ser Pro Ile Lys Glu Ser Leu Phe Arg Ser Ser Ser Lys 
            100                 105                 110         


Glu Ser Leu Val Arg Thr Ser Ser Arg Glu Ser Leu Asn Arg Leu Asp 
        115                 120                 125             


Leu Asp Ser Ser Thr Ala Ser Phe Asp Pro Pro Ser Asp Met Asp Ser 
    130                 135                 140                 


Glu Ala Glu Asp Leu Val Gly Asn Ser Asp Ser Leu Asn Lys Glu Gln 
145                 150                 155                 160 


Leu Ile Gln Arg Leu Arg Arg Met Glu Arg Ser Leu Ser Ser Tyr Arg 
                165                 170                 175     


Gly Lys Tyr Ser Glu Leu Val Thr Ala Tyr Gln Met Leu Gln Arg Glu 
            180                 185                 190         


Lys Lys Lys Leu Gln Gly Ile Leu Ser Gln Ser Gln Asp Lys Ser Leu 
        195                 200                 205             


Arg Arg Ile Ala Glu Leu Arg Glu Glu Leu Gln Met Asp Gln Gln Ala 
    210                 215                 220                 


Lys Lys His Leu Gln Glu Glu Phe Asp Ala Ser Leu Glu Glu Lys Asp 
225                 230                 235                 240 


Gln Tyr Ile Ser Val Leu Gln Thr Gln Val Ser Leu Leu Lys Gln Arg 
                245                 250                 255     


Leu Arg Asn Gly Pro Met Asn Val Asp Val Leu Lys Pro Leu Pro Gln 
            260                 265                 270         


Leu Glu Pro Gln Ala Glu Val Phe Thr Lys Glu Glu Asn Pro Glu Ser 
        275                 280                 285             


Asp Gly Glu Pro Val Val Glu Asp Gly Thr Ser Val Lys Thr Leu Glu 
    290                 295                 300                 


Thr Leu Gln Gln Arg Val Lys Arg Gln Glu Asn Leu Leu Lys Arg Cys 
305                 310                 315                 320 


Lys Glu Thr Ile Gln Ser His Lys Glu Gln Cys Thr Leu Leu Thr Ser 
                325                 330                 335     


Glu Lys Glu Ala Leu Gln Glu Gln Leu Asp Glu Arg Leu Gln Glu Leu 
            340                 345                 350         


Glu Lys Ile Lys Asp Leu His Met Ala Glu Lys Thr Lys Leu Ile Thr 
        355                 360                 365             


Gln Leu Arg Asp Ala Lys Asn Leu Ile Glu Gln Leu Glu Gln Asp Lys 
    370                 375                 380                 


Gly Met Val Ile Ala Glu Thr Lys Arg Gln Met His Glu Thr Leu Glu 
385                 390                 395                 400 


Met Lys Glu Glu Glu Ile Ala Gln Leu Arg Ser Arg Ile Lys Gln Met 
                405                 410                 415     


Thr Thr Gln Gly Glu Glu Leu Arg Glu Gln Lys Glu Lys Ser Glu Arg 
            420                 425                 430         


Ala Ala Phe Glu Glu Leu Glu Lys Ala Leu Ser Thr Ala Gln Lys Thr 
        435                 440                 445             


Glu Glu Ala Arg Arg Lys Leu Lys Ala Glu Met Asp Glu Gln Ile Lys 
    450                 455                 460                 


Thr Ile Glu Lys Thr Ser Glu Glu Glu Arg Ile Ser Leu Gln Gln Glu 
465                 470                 475                 480 


Leu Ser Arg Val Lys Gln Glu Val Val Asp Val Met Lys Lys Ser Ser 
                485                 490                 495     


Glu Glu Gln Ile Ala Lys Leu Gln Lys Leu His Glu Lys Glu Leu Ala 
            500                 505                 510         


Arg Lys Glu Gln Glu Leu Thr Lys Lys Leu Gln Thr Arg Glu Arg Glu 
        515                 520                 525             


Phe Gln Glu Gln Met Lys Val Ala Leu Glu Lys Ser Gln Ser Glu Tyr 
    530                 535                 540                 


Leu Lys Ile Ser Gln Glu Lys Glu Gln Gln Glu Ser Leu Ala Leu Glu 
545                 550                 555                 560 


Glu Leu Glu Leu Gln Lys Lys Ala Ile Leu Thr Glu Ser Glu Asn Lys 
                565                 570                 575     


Leu Arg Asp Leu Gln Gln Glu Ala Glu Thr Tyr Arg Thr Arg Ile Leu 
            580                 585                 590         


Glu Leu Glu Ser Ser Leu Glu Lys Ser Leu Gln Glu Asn Lys Asn Gln 
        595                 600                 605             


Ser Lys Asp Leu Ala Val His Leu Glu Ala Glu Lys Asn Lys His Asn 
    610                 615                 620                 


Lys Glu Ile Thr Val Met Val Glu Lys His Lys Thr Glu Leu Glu Ser 
625                 630                 635                 640 


Leu Lys His Gln Gln Asp Ala Leu Trp Thr Glu Lys Leu Gln Val Leu 
                645                 650                 655     


Lys Gln Gln Tyr Gln Thr Glu Met Glu Lys Leu Arg Glu Lys Cys Glu 
            660                 665                 670         


Gln Glu Lys Glu Thr Leu Leu Lys Asp Lys Glu Ile Ile Phe Gln Ala 
        675                 680                 685             


His Ile Glu Glu Met Asn Glu Lys Thr Leu Glu Lys Leu Asp Val Lys 
    690                 695                 700                 


Gln Thr Glu Leu Glu Ser Leu Ser Ser Glu Leu Ser Glu Val Leu Lys 
705                 710                 715                 720 


Ala Arg His Lys Leu Glu Glu Glu Leu Ser Val Leu Lys Asp Gln Thr 
                725                 730                 735     


Asp Lys Met Lys Gln Glu Leu Glu Ala Lys Met Asp Glu Gln Lys Asn 
            740                 745                 750         


His His Gln Gln Gln Val Asp Ser Ile Ile Lys Glu His Glu Val Ser 
        755                 760                 765             


Ile Gln Arg Thr Glu Lys Ala Leu Lys Asp Gln Ile Asn Gln Leu Glu 
    770                 775                 780                 


Leu Leu Leu Lys Glu Arg Asp Lys His Leu Lys Glu His Gln Ala His 
785                 790                 795                 800 


Val Glu Asn Leu Glu Ala Asp Ile Lys Arg Ser Glu Gly Glu Leu Gln 
                805                 810                 815     


Gln Ala Ser Ala Lys Leu Asp Val Phe Gln Ser Tyr Gln Ser Ala Thr 
            820                 825                 830         


His Glu Gln Thr Lys Ala Tyr Glu Glu Gln Leu Ala Gln Leu Gln Gln 
        835                 840                 845             


Lys Leu Leu Asp Leu Glu Thr Glu Arg Ile Leu Leu Thr Lys Gln Val 
    850                 855                 860                 


Ala Glu Val Glu Ala Gln Lys Lys Asp Val Cys Thr Glu Leu Asp Ala 
865                 870                 875                 880 


His Lys Ile Gln Val Gln Asp Leu Met Gln Gln Leu Glu Lys Gln Asn 
                885                 890                 895     


Ser Glu Met Glu Gln Lys Val Lys Ser Leu Thr Gln Val Tyr Glu Ser 
            900                 905                 910         


Lys Leu Glu Asp Gly Asn Lys Glu Gln Glu Gln Thr Lys Gln Ile Leu 
        915                 920                 925             


Val Glu Lys Glu Asn Met Ile Leu Gln Met Arg Glu Gly Gln Lys Lys 
    930                 935                 940                 


Glu Ile Glu Ile Leu Thr Gln Lys Leu Ser Ala Lys Glu Asp Ser Ile 
945                 950                 955                 960 


His Ile Leu Asn Glu Glu Tyr Glu Thr Lys Phe Lys Asn Gln Glu Lys 
                965                 970                 975     


Lys Met Glu Lys Val Lys Gln Lys Ala Lys Glu Met Gln Glu Thr Leu 
            980                 985                 990         


Lys Lys Lys Leu Leu Asp Gln Glu  Ala Lys Leu Lys Lys  Glu Leu Glu 
        995                 1000                 1005             


Asn Thr  Ala Leu Glu Leu Ser  Gln Lys Glu Lys Gln  Phe Asn Ala 
    1010                 1015                 1020             


Lys Met  Leu Glu Met Ala Gln  Ala Asn Ser Ala Gly  Ile Ser Asp 
    1025                 1030                 1035             


Ala Val  Ser Arg Leu Glu Thr  Asn Gln Lys Glu Gln  Ile Glu Ser 
    1040                 1045                 1050             


Leu Thr  Glu Val His Arg Arg  Glu Leu Asn Asp Val  Ile Ser Ile 
    1055                 1060                 1065             


Trp Glu  Lys Lys Leu Asn Gln  Gln Ala Glu Glu Leu  Gln Glu Ile 
    1070                 1075                 1080             


His Glu  Ile Gln Leu Gln Glu  Lys Glu Gln Glu Val  Ala Glu Leu 
    1085                 1090                 1095             


Lys Gln  Lys Ile Leu Leu Phe  Gly Cys Glu Lys Glu  Glu Met Asn 
    1100                 1105                 1110             


Lys Glu  Ile Thr Trp Leu Lys  Glu Glu Gly Val Lys  Gln Asp Thr 
    1115                 1120                 1125             


Thr Leu  Asn Glu Leu Gln Glu  Gln Leu Lys Gln Lys  Ser Ala His 
    1130                 1135                 1140             


Val Asn  Ser Leu Ala Gln Asp  Glu Thr Lys Leu Lys  Ala His Leu 
    1145                 1150                 1155             


Glu Lys  Leu Glu Val Asp Leu  Asn Lys Ser Leu Lys  Glu Asn Thr 
    1160                 1165                 1170             


Phe Leu  Gln Glu Gln Leu Val  Glu Leu Lys Met Leu  Ala Glu Glu 
    1175                 1180                 1185             


Asp Lys  Arg Lys Val Ser Glu  Leu Thr Ser Lys Leu  Lys Thr Thr 
    1190                 1195                 1200             


Asp Glu  Glu Phe Gln Ser Leu  Lys Ser Ser His Glu  Lys Ser Asn 
    1205                 1210                 1215             


Lys Ser  Leu Glu Asp Lys Ser  Leu Glu Phe Lys Lys  Leu Ser Glu 
    1220                 1225                 1230             


Glu Leu  Ala Ile Gln Leu Asp  Ile Cys Cys Lys Lys  Thr Glu Ala 
    1235                 1240                 1245             


Leu Leu  Glu Ala Lys Thr Asn  Glu Leu Ile Asn Ile  Ser Ser Ser 
    1250                 1255                 1260             


Lys Thr  Asn Ala Ile Leu Ser  Arg Ile Ser His Cys  Gln His Arg 
    1265                 1270                 1275             


Thr Thr  Lys Val Lys Glu Ala  Leu Leu Ile Lys Thr  Cys Thr Val 
    1280                 1285                 1290             


Ser Glu  Leu Glu Ala Gln Leu  Arg Gln Leu Thr Glu  Glu Gln Asn 
    1295                 1300                 1305             


Thr Leu  Asn Ile Ser Phe Gln  Gln Ala Thr His Gln  Leu Glu Glu 
    1310                 1315                 1320             


Lys Glu  Asn Gln Ile Lys Ser  Met Lys Ala Asp Ile  Glu Ser Leu 
    1325                 1330                 1335             


Val Thr  Glu Lys Glu Ala Leu  Gln Lys Glu Gly Gly  Asn Gln Gln 
    1340                 1345                 1350             


Gln Ala  Ala Ser Glu Lys Glu  Ser Cys Ile Thr Gln  Leu Lys Lys 
    1355                 1360                 1365             


Glu Leu  Ser Glu Asn Ile Asn  Ala Val Thr Leu Met  Lys Glu Glu 
    1370                 1375                 1380             


Leu Lys  Glu Lys Lys Val Glu  Ile Ser Ser Leu Ser  Lys Gln Leu 
    1385                 1390                 1395             


Thr Asp  Leu Asn Val Gln Leu  Gln Asn Ser Ile Ser  Leu Ser Glu 
    1400                 1405                 1410             


Lys Glu  Ala Ala Ile Ser Ser  Leu Arg Lys Gln Tyr  Asp Glu Glu 
    1415                 1420                 1425             


Lys Cys  Glu Leu Leu Asp Gln  Val Gln Asp Leu Ser  Phe Lys Val 
    1430                 1435                 1440             


Asp Thr  Leu Ser Lys Glu Lys  Ile Ser Ala Leu Glu  Gln Val Asp 
    1445                 1450                 1455             


Asp Trp  Ser Asn Lys Phe Ser  Glu Trp Lys Lys Lys  Ala Gln Ser 
    1460                 1465                 1470             


Arg Phe  Thr Gln His Gln Asn  Thr Val Lys Glu Leu  Gln Ile Gln 
    1475                 1480                 1485             


Leu Glu  Leu Lys Ser Lys Glu  Ala Tyr Glu Lys Asp  Glu Gln Ile 
    1490                 1495                 1500             


Asn Leu  Leu Lys Glu Glu Leu  Asp Gln Gln Asn Lys  Arg Phe Asp 
    1505                 1510                 1515             


Cys Leu  Lys Gly Glu Met Glu  Asp Asp Lys Ser Lys  Met Glu Lys 
    1520                 1525                 1530             


Lys Glu  Ser Asn Leu Glu Thr  Glu Leu Lys Ser Gln  Thr Ala Arg 
    1535                 1540                 1545             


Ile Met  Glu Leu Glu Asp His  Ile Thr Gln Lys Thr  Ile Glu Ile 
    1550                 1555                 1560             


Glu Ser  Leu Asn Glu Val Leu  Lys Asn Tyr Asn Gln  Gln Lys Asp 
    1565                 1570                 1575             


Ile Glu  His Lys Glu Leu Val  Gln Lys Leu Gln His  Phe Gln Glu 
    1580                 1585                 1590             


Leu Gly  Glu Glu Lys Asp Asn  Arg Val Lys Glu Ala  Glu Glu Lys 
    1595                 1600                 1605             


Ile Leu  Thr Leu Glu Asn Gln  Val Tyr Ser Met Lys  Ala Glu Leu 
    1610                 1615                 1620             


Glu Thr  Lys Lys Lys Glu Leu  Glu His Val Asn Leu  Ser Val Lys 
    1625                 1630                 1635             


Ser Lys  Glu Glu Glu Leu Lys  Ala Leu Glu Asp Arg  Leu Glu Ser 
    1640                 1645                 1650             


Glu Ser  Ala Ala Lys Leu Ala  Glu Leu Lys Arg Lys  Ala Glu Gln 
    1655                 1660                 1665             


Lys Ile  Ala Ala Ile Lys Lys  Gln Leu Leu Ser Gln  Met Glu Glu 
    1670                 1675                 1680             


Lys Glu  Glu Gln Tyr Lys Lys  Gly Thr Glu Ser His  Leu Ser Glu 
    1685                 1690                 1695             


Leu Asn  Thr Lys Leu Gln Glu  Arg Glu Arg Glu Val  His Ile Leu 
    1700                 1705                 1710             


Glu Glu  Lys Leu Lys Ser Val  Glu Ser Ser Gln Ser  Glu Thr Leu 
    1715                 1720                 1725             


Ile Val  Pro Arg Ser Ala Lys  Asn Val Ala Ala Tyr  Thr Glu Gln 
    1730                 1735                 1740             


Glu Glu  Ala Asp Ser Gln Gly  Cys Val Gln Lys Thr  Tyr Glu Glu 
    1745                 1750                 1755             


Lys Ile  Ser Val Leu Gln Arg  Asn Leu Thr Glu Lys  Glu Lys Leu 
    1760                 1765                 1770             


Leu Gln  Arg Val Gly Gln Glu  Lys Glu Glu Thr Val  Ser Ser His 
    1775                 1780                 1785             


Phe Glu  Met Arg Cys Gln Tyr  Gln Glu Arg Leu Ile  Lys Leu Glu 
    1790                 1795                 1800             


His Ala  Glu Ala Lys Gln His  Glu Asp Gln Ser Met  Ile Gly His 
    1805                 1810                 1815             


Leu Gln  Glu Glu Leu Glu Glu  Lys Asn Lys Lys Tyr  Ser Leu Ile 
    1820                 1825                 1830             


Val Ala  Gln His Val Glu Lys  Glu Gly Gly Lys Asn  Asn Ile Gln 
    1835                 1840                 1845             


Ala Lys  Gln Asn Leu Glu Asn  Val Phe Asp Asp Val  Gln Lys Thr 
    1850                 1855                 1860             


Leu Gln  Glu Lys Glu Leu Thr  Cys Gln Ile Leu Glu  Gln Lys Ile 
    1865                 1870                 1875             


Lys Glu  Leu Asp Ser Cys Leu  Val Arg Gln Lys Glu  Val His Arg 
    1880                 1885                 1890             


Val Glu  Met Glu Glu Leu Thr  Ser Lys Tyr Glu Lys  Leu Gln Ala 
    1895                 1900                 1905             


Leu Gln  Gln Met Asp Gly Arg  Asn Lys Pro Thr Glu  Leu Leu Glu 
    1910                 1915                 1920             


Glu Asn  Thr Glu Glu Lys Ser  Lys Ser His Leu Val  Gln Pro Lys 
    1925                 1930                 1935             


Leu Leu  Ser Asn Met Glu Ala  Gln His Asn Asp Leu  Glu Phe Lys 
    1940                 1945                 1950             


Leu Ala  Gly Ala Glu Arg Glu  Lys Gln Lys Leu Gly  Lys Glu Ile 
    1955                 1960                 1965             


Val Arg  Leu Gln Lys Asp Leu  Arg Met Leu Arg Lys  Glu His Gln 
    1970                 1975                 1980             


Gln Glu  Leu Glu Ile Leu Lys  Lys Glu Tyr Asp Gln  Glu Arg Glu 
    1985                 1990                 1995             


Glu Lys  Ile Lys Gln Glu Gln  Glu Asp Leu Glu Leu  Lys His Asn 
    2000                 2005                 2010             


Ser Thr  Leu Lys Gln Leu Met  Arg Glu Phe Asn Thr  Gln Leu Ala 
    2015                 2020                 2025             


Gln Lys  Glu Gln Glu Leu Glu  Met Thr Ile Lys Glu  Thr Ile Asn 
    2030                 2035                 2040             


Lys Ala  Gln Glu Val Glu Ala  Glu Leu Leu Glu Ser  His Gln Glu 
    2045                 2050                 2055             


Glu Thr  Asn Gln Leu Leu Lys  Lys Ile Ala Glu Lys  Asp Asp Asp 
    2060                 2065                 2070             


Leu Lys  Arg Thr Ala Lys Arg  Tyr Glu Glu Ile Leu  Asp Ala Arg 
    2075                 2080                 2085             


Glu Glu  Glu Met Thr Ala Lys  Val Arg Asp Leu Gln  Thr Gln Leu 
    2090                 2095                 2100             


Glu Glu  Leu Gln Lys Lys Tyr  Gln Gln Lys Leu Glu  Gln Glu Glu 
    2105                 2110                 2115             


Asn Pro  Gly Asn Asp Asn Thr  Gln Leu Ala Gln Lys  Thr Thr Leu 
    2120                 2125                 2130             


Ile Ser  Asp Ser Lys Leu Lys  Glu Gln Glu Phe Arg  Glu Gln Ile 
    2135                 2140                 2145             


His Asn  Leu Glu Asp Arg Leu  Lys Lys Tyr Glu Lys  Asn Val Tyr 
    2150                 2155                 2160             


Ala Thr  Thr Val Gly Thr Pro  Tyr Lys Gly Gly Asn  Leu Tyr His 
    2165                 2170                 2175             


Thr Asp  Val Ser Leu Phe Gly  Glu Pro Thr Glu Phe  Glu Tyr Leu 
    2180                 2185                 2190             


Arg Lys  Val Leu Phe Glu Tyr  Met Met Gly Arg Glu  Thr Lys Thr 
    2195                 2200                 2205             


Met Ala  Lys Val Ile Thr Thr  Val Leu Lys Phe Pro  Asp Asp Gln 
    2210                 2215                 2220             


Thr Gln  Lys Ile Leu Glu Arg  Glu Asp Ala Arg Leu  Met Ser Trp 
    2225                 2230                 2235             


Leu Arg  Ser Ser Ser 
    2240             


<210>  4578
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLGA5__Homo_sapiens__NP_005104

<400>  4578

Met Ser Trp Phe Val Asp Leu Ala Gly Lys Ala Glu Asp Leu Leu Asn 
1               5                   10                  15      


Arg Val Asp Gln Gly Ala Ala Thr Ala Leu Ser Arg Lys Asp Asn Ala 
            20                  25                  30          


Ser Asn Ile Tyr Ser Lys Asn Thr Asp Tyr Thr Glu Leu His Gln Gln 
        35                  40                  45              


Asn Thr Asp Leu Ile Tyr Gln Thr Gly Pro Lys Ser Thr Tyr Ile Ser 
    50                  55                  60                  


Ser Ala Ala Asp Asn Ile Arg Asn Gln Lys Ala Thr Ile Leu Ala Gly 
65                  70                  75                  80  


Thr Ala Asn Val Lys Val Gly Ser Arg Thr Pro Val Glu Ala Ser His 
                85                  90                  95      


Pro Val Glu Asn Ala Ser Val Pro Arg Pro Ser Ser His Phe Val Arg 
            100                 105                 110         


Arg Lys Lys Ser Glu Pro Asp Asp Glu Leu Leu Phe Asp Phe Leu Asn 
        115                 120                 125             


Ser Ser Gln Lys Glu Pro Thr Gly Arg Val Glu Ile Arg Lys Glu Lys 
    130                 135                 140                 


Gly Lys Thr Pro Val Phe Gln Ser Ser Gln Thr Ser Ser Val Ser Ser 
145                 150                 155                 160 


Val Asn Pro Ser Val Thr Thr Ile Lys Thr Ile Glu Glu Asn Ser Phe 
                165                 170                 175     


Gly Ser Gln Thr His Glu Ala Ala Ser Asn Ser Asp Ser Ser His Glu 
            180                 185                 190         


Gly Gln Glu Glu Ser Ser Lys Glu Asn Val Ser Ser Asn Ala Ala Cys 
        195                 200                 205             


Pro Asp His Thr Pro Thr Pro Asn Asp Asp Gly Lys Ser His Glu Leu 
    210                 215                 220                 


Ser Asn Leu Arg Leu Glu Asn Gln Leu Leu Arg Asn Glu Val Gln Ser 
225                 230                 235                 240 


Leu Asn Gln Glu Met Ala Ser Leu Leu Gln Arg Ser Lys Glu Thr Gln 
                245                 250                 255     


Glu Glu Leu Asn Lys Ala Arg Ala Arg Val Glu Lys Trp Asn Ala Asp 
            260                 265                 270         


His Ser Lys Ser Asp Arg Met Thr Arg Gly Leu Arg Ala Gln Val Asp 
        275                 280                 285             


Asp Leu Thr Glu Ala Val Ala Ala Lys Asp Ser Gln Leu Ala Val Leu 
    290                 295                 300                 


Lys Val Arg Leu Gln Glu Ala Asp Gln Leu Leu Ser Thr Arg Thr Glu 
305                 310                 315                 320 


Ala Leu Glu Ala Leu Gln Ser Glu Lys Ser Arg Ile Met Gln Asp Gln 
                325                 330                 335     


Ser Glu Gly Asn Ser Leu Gln Asn Gln Ala Leu Gln Thr Leu Gln Glu 
            340                 345                 350         


Arg Leu His Glu Ala Asp Ala Thr Leu Lys Arg Glu Gln Glu Ser Tyr 
        355                 360                 365             


Lys Gln Met Gln Ser Glu Phe Ala Ala Arg Leu Asn Lys Val Glu Met 
    370                 375                 380                 


Glu Arg Gln Asn Leu Ala Glu Ala Ile Thr Leu Ala Glu Arg Lys Tyr 
385                 390                 395                 400 


Ser Asp Glu Lys Lys Arg Val Asp Glu Leu Gln Gln Gln Val Lys Leu 
                405                 410                 415     


Tyr Lys Leu Asn Leu Glu Ser Ser Lys Gln Glu Leu Ile Asp Tyr Lys 
            420                 425                 430         


Gln Lys Ala Thr Arg Ile Leu Gln Ser Lys Glu Lys Leu Ile Asn Ser 
        435                 440                 445             


Leu Lys Glu Gly Ser Gly Phe Glu Gly Leu Asp Ser Ser Thr Ala Ser 
    450                 455                 460                 


Ser Met Glu Leu Glu Glu Leu Arg His Glu Lys Glu Met Gln Arg Glu 
465                 470                 475                 480 


Glu Ile Gln Lys Leu Met Gly Gln Ile His Gln Leu Arg Ser Glu Leu 
                485                 490                 495     


Gln Asp Met Glu Ala Gln Gln Val Asn Glu Ala Glu Ser Ala Arg Glu 
            500                 505                 510         


Gln Leu Gln Asp Leu His Asp Gln Ile Ala Gly Gln Lys Ala Ser Lys 
        515                 520                 525             


Gln Glu Leu Glu Thr Glu Leu Glu Arg Leu Lys Gln Glu Phe His Tyr 
    530                 535                 540                 


Ile Glu Glu Asp Leu Tyr Arg Thr Lys Asn Thr Leu Gln Ser Arg Ile 
545                 550                 555                 560 


Lys Asp Arg Asp Glu Glu Ile Gln Lys Leu Arg Asn Gln Leu Thr Asn 
                565                 570                 575     


Lys Thr Leu Ser Asn Ser Ser Gln Ser Glu Leu Glu Asn Arg Leu His 
            580                 585                 590         


Gln Leu Thr Glu Thr Leu Ile Gln Lys Gln Thr Met Leu Glu Ser Leu 
        595                 600                 605             


Ser Thr Glu Lys Asn Ser Leu Val Phe Gln Leu Glu Arg Leu Glu Gln 
    610                 615                 620                 


Gln Met Asn Ser Ala Ser Gly Ser Ser Ser Asn Gly Ser Ser Ile Asn 
625                 630                 635                 640 


Met Ser Gly Ile Asp Asn Gly Glu Gly Thr Arg Leu Arg Asn Val Pro 
                645                 650                 655     


Val Leu Phe Asn Asp Thr Glu Thr Asn Leu Ala Gly Met Tyr Gly Lys 
            660                 665                 670         


Val Arg Lys Ala Ala Ser Ser Ile Asp Gln Phe Ser Ile Arg Leu Gly 
        675                 680                 685             


Ile Phe Leu Arg Arg Tyr Pro Ile Ala Arg Val Phe Val Ile Ile Tyr 
    690                 695                 700                 


Met Ala Leu Leu His Leu Trp Val Met Ile Val Leu Leu Thr Tyr Thr 
705                 710                 715                 720 


Pro Glu Met His His Asp Gln Pro Tyr Gly Lys 
                725                 730     


<210>  4579
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLGA8B__Homo_sapiens__NP_001018861

<400>  4579

Met Ala Glu Glu Thr Gly Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys 
1               5                   10                  15      


Phe Lys Glu Tyr Trp Gln Arg Asn Arg Pro Gly Val Pro Ala Ala Ala 
            20                  25                  30          


Lys Arg Asn Thr Lys Ala Asn Gly Ser Ser Pro Glu Thr Ala Ala Ser 
        35                  40                  45              


Gly Gly Cys His Ser Ser Glu Ala Ser Ser Ser Ala Ser Ser Ser Leu 
    50                  55                  60                  


His Ala Arg Gln Ser Pro Cys Gln Glu Gln Ala Ala Val Leu Asn Ser 
65                  70                  75                  80  


Arg Ser Ile Lys Ile Ser Arg Leu Asn Asp Thr Ile Lys Ser Leu Lys 
                85                  90                  95      


Gln Gln Lys Lys Gln Val Glu His Gln Leu Glu Glu Glu Lys Lys Ala 
            100                 105                 110         


Asn Asn Glu Lys Gln Lys Ala Glu Arg Glu Leu Glu Gly Gln Ile Gln 
        115                 120                 125             


Arg Leu Asn Thr Glu Lys Lys Lys Leu Asn Thr Asp Leu Tyr His Met 
    130                 135                 140                 


Lys His Ser Leu Arg Tyr Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly 
145                 150                 155                 160 


Arg Leu Gln Arg Ser Ser Gln Arg Ile Gly Glu Leu Glu Trp Ser Leu 
                165                 170                 175     


Cys Ala Val Ala Ala Thr Gln Lys Lys Lys Pro Asp Gly Phe Ser Ser 
            180                 185                 190         


Arg Ser Lys Ala Leu Leu Lys Arg Gln Leu Glu Gln Ser Ile Arg Glu 
        195                 200                 205             


Gln Ile Leu Leu Lys Gly His Val Thr Gln Leu Lys Glu Ser Leu Lys 
    210                 215                 220                 


Glu Val Gln Leu Glu Arg Asp Gln Tyr Ala Glu Gln Ile Lys Gly Glu 
225                 230                 235                 240 


Arg Ala Gln Trp Gln Gln Arg Met Arg Lys Met Ser Gln Glu Val Cys 
                245                 250                 255     


Thr Leu Lys Glu Glu Lys Lys His Asp Thr His Arg Val Glu Glu Leu 
            260                 265                 270         


Glu Arg Ser Leu Ser Arg Leu Lys Asn Gln Met Ala Glu Pro Leu Pro 
        275                 280                 285             


Pro Asp Ala Pro Ala Val Ser Ser Glu Val Glu Leu Gln Asp Leu Arg 
    290                 295                 300                 


Lys Glu Leu Glu Arg Val Ala Gly Glu Leu Gln Ala Gln Val Glu Asn 
305                 310                 315                 320 


Asn Gln Cys Ile Ser Leu Leu Asn Arg Gly Gln Lys Glu Arg Leu Arg 
                325                 330                 335     


Glu Gln Glu Glu Arg Leu Gln Glu Gln Gln Glu Arg Leu Arg Glu Arg 
            340                 345                 350         


Glu Lys Arg Leu Gln Gln Leu Ala Glu Pro Gln Ser Asp Leu Glu Glu 
        355                 360                 365             


Leu Lys His Glu Asn Lys Ser Ala Leu Gln Leu Glu Gln Gln Val Lys 
    370                 375                 380                 


Glu Leu Gln Glu Lys Leu Gly Gln Val Met Glu Thr Leu Thr Ser Ala 
385                 390                 395                 400 


Glu Lys Glu Pro Glu Ala Ala Val Pro Ala Ser Gly Thr Gly Gly Glu 
                405                 410                 415     


Ser Ser Gly Leu Met Asp Leu Leu Glu Glu Lys Ala Asp Leu Arg Glu 
            420                 425                 430         


His Val Glu Lys Leu Glu Leu Gly Phe Ile Gln Tyr Arg Arg Glu Arg 
        435                 440                 445             


Cys His Gln Lys Val His Arg Leu Leu Thr Glu Pro Gly Asp Ser Ala 
    450                 455                 460                 


Lys Asp Ala Ser Pro Gly Gly Gly His His Gln Ala Gly Pro Gly Gln 
465                 470                 475                 480 


Gly Gly Glu Glu Gly Glu Ala Ala Gly Ala Ala Gly Asp Gly Val Ala 
                485                 490                 495     


Ala Cys Gly Ser Tyr Ser Glu Gly His Gly Lys Phe Leu Ala Ala Ala 
            500                 505                 510         


Arg Asn Pro Ala Ala Glu Pro Ser Pro Gly Ala Pro Ala Pro Gln Glu 
        515                 520                 525             


Leu Gly Ala Ala Asp Lys His Gly Asp Leu Cys Glu Ala Ser Leu Thr 
    530                 535                 540                 


Asn Ser Val Glu Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Ser Gln 
545                 550                 555                 560 


Asp Asn Pro Thr Ala Gln Pro Val Leu Gln Leu Leu Gly Glu Met Gln 
                565                 570                 575     


Asp His Gln Glu His Pro Gly Leu Gly Ser Asn Cys Cys Val Pro Cys 
            580                 585                 590         


Phe Cys Trp Ala Trp Leu Pro Arg Arg Arg Arg 
        595                 600             


<210>  4580
<211>  3269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLGB1__Homo_sapiens__NP_001243415

<400>  4580

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
1               5                   10                  15      


Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
            20                  25                  30          


Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
        35                  40                  45              


Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
    50                  55                  60                  


Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
65                  70                  75                  80  


Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                85                  90                  95      


Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
            100                 105                 110         


Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
        115                 120                 125             


Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
    130                 135                 140                 


Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
145                 150                 155                 160 


Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                165                 170                 175     


Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
            180                 185                 190         


Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
        195                 200                 205             


Thr Gln Ala Glu Gln Ala Ala Gln Leu Ser Ser Met Gln Gln Val Val 
    210                 215                 220                 


Arg Glu Lys Asp Ala Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp 
225                 230                 235                 240 


Glu Leu Leu Gln Leu Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln 
                245                 250                 255     


Gln Lys Leu Arg Val Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser 
            260                 265                 270         


Leu Val Gly Arg Ala Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr 
        275                 280                 285             


Ala Ala Glu Gln Arg Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met 
    290                 295                 300                 


Glu Ala Glu His Asn Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu 
305                 310                 315                 320 


Glu Ser Lys Ile Leu Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg 
                325                 330                 335     


Lys Leu Ser Phe His Asn Leu Gln Glu Glu Met His His Leu Leu Glu 
            340                 345                 350         


Gln Phe Glu Gln Ala Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr 
        355                 360                 365             


Ser Ala Leu Glu Gln Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser 
    370                 375                 380                 


His Ile Leu Ser Leu Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys 
385                 390                 395                 400 


Asp Ala Leu Lys Asp Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu 
                405                 410                 415     


Gln Ala Val Gln Ser Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu 
            420                 425                 430         


Gln Gln Lys Ser Lys Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu 
        435                 440                 445             


Gln Gln His Glu Thr Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn 
    450                 455                 460                 


Glu Gly Thr Gln Ala Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys 
465                 470                 475                 480 


Arg Val Val Glu Leu Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser 
                485                 490                 495     


Ile Glu Leu Glu Glu Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln 
            500                 505                 510         


Ile Thr Leu Leu Glu Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu 
        515                 520                 525             


Val Ser Glu Ile Ser Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser 
    530                 535                 540                 


Ala Glu Glu Ser Gly Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys 
545                 550                 555                 560 


His Lys Glu Leu Ser Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu 
                565                 570                 575     


Glu Ile Ala Phe Leu Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu 
            580                 585                 590         


Ala Asp His Glu Val Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly 
        595                 600                 605             


Glu Gly Ile Ala Pro Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly 
    610                 615                 620                 


Gln Asp Phe Pro Leu Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val 
625                 630                 635                 640 


Glu Lys Glu Gln Ala Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu 
                645                 650                 655     


Ile Ser Leu Asn Asp Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp 
            660                 665                 670         


Gly Asp Lys Ser Leu Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln 
        675                 680                 685             


Asp Glu Leu Glu Arg Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn 
    690                 695                 700                 


Phe His Lys Ala Gln Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala 
705                 710                 715                 720 


Lys Glu Ile Ser Asn Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn 
                725                 730                 735     


Ala Asp Asn Asn Ser Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp 
            740                 745                 750         


Gln Leu Leu Ser Gln Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg 
        755                 760                 765             


Ala Gln Val Lys Gln Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln 
    770                 775                 780                 


Arg Arg Leu Asp Tyr Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr 
785                 790                 795                 800 


Glu Gln Ile His Ser Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys 
                805                 810                 815     


Ile Glu Val Leu Gln Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser 
            820                 825                 830         


Glu Gln Ser Thr Leu Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys 
        835                 840                 845             


Glu Ser Glu Val Leu Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser 
    850                 855                 860                 


Lys Val Glu Glu Leu Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile 
865                 870                 875                 880 


Thr Lys Met Asp Gln Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr 
                885                 890                 895     


Leu Gln Gln Thr Ile Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser 
            900                 905                 910         


Phe Ser Met Thr Glu Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser 
        915                 920                 925             


Leu Gly Val Glu Ile Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser 
    930                 935                 940                 


Arg Ala Glu Glu Ala Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val 
945                 950                 955                 960 


Ser Ser Gly Leu Lys Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln 
                965                 970                 975     


Ile Ser Lys Glu Glu Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu 
            980                 985                 990         


Asn Glu Gln Arg Lys Arg Lys Leu  Gln Ala Ala Leu Ile  Asn Arg Lys 
        995                 1000                 1005             


Glu Leu  Leu Gln Arg Val Ser  Arg Leu Glu Glu Glu  Leu Ala Asn 
    1010                 1015                 1020             


Leu Lys  Asp Glu Ser Lys Lys  Glu Ile Pro Leu Ser  Glu Thr Glu 
    1025                 1030                 1035             


Arg Gly  Glu Val Glu Glu Asp  Lys Glu Asn Lys Glu  Tyr Ser Glu 
    1040                 1045                 1050             


Lys Cys  Val Thr Ser Lys Cys  Gln Glu Ile Glu Ile  Tyr Leu Lys 
    1055                 1060                 1065             


Gln Thr  Ile Ser Glu Lys Glu  Val Glu Leu Gln His  Ile Arg Lys 
    1070                 1075                 1080             


Asp Leu  Glu Glu Lys Leu Ala  Ala Glu Glu Gln Phe  Gln Ala Leu 
    1085                 1090                 1095             


Val Lys  Gln Met Asn Gln Thr  Leu Gln Asp Lys Thr  Asn Gln Ile 
    1100                 1105                 1110             


Asp Leu  Leu Gln Ala Glu Ile  Ser Glu Asn Gln Ala  Ile Ile Gln 
    1115                 1120                 1125             


Lys Leu  Ile Thr Ser Asn Thr  Asp Ala Ser Asp Gly  Asp Ser Val 
    1130                 1135                 1140             


Ala Leu  Val Lys Glu Thr Val  Val Ile Ser Pro Pro  Cys Thr Gly 
    1145                 1150                 1155             


Ser Ser  Glu His Trp Lys Pro  Glu Leu Glu Glu Lys  Ile Leu Ala 
    1160                 1165                 1170             


Leu Glu  Lys Glu Lys Glu Gln  Leu Gln Lys Lys Leu  Gln Glu Ala 
    1175                 1180                 1185             


Leu Thr  Ser Arg Lys Ala Ile  Leu Lys Lys Ala Gln  Glu Lys Glu 
    1190                 1195                 1200             


Arg His  Leu Arg Glu Glu Leu  Lys Gln Gln Lys Asp  Asp Tyr Asn 
    1205                 1210                 1215             


Arg Leu  Gln Glu Gln Phe Asp  Glu Gln Ser Lys Glu  Asn Glu Asn 
    1220                 1225                 1230             


Ile Gly  Asp Gln Leu Arg Gln  Leu Gln Ile Gln Val  Arg Glu Ser 
    1235                 1240                 1245             


Ile Asp  Gly Lys Leu Pro Ser  Thr Asp Gln Gln Glu  Ser Cys Ser 
    1250                 1255                 1260             


Ser Thr  Pro Gly Leu Glu Glu  Pro Leu Phe Lys Ala  Thr Glu Gln 
    1265                 1270                 1275             


His His  Thr Gln Pro Val Leu  Glu Ser Asn Leu Cys  Pro Asp Trp 
    1280                 1285                 1290             


Pro Ser  His Ser Glu Asp Ala  Ser Ala Leu Gln Gly  Gly Thr Ser 
    1295                 1300                 1305             


Val Ala  Gln Ile Lys Ala Gln  Leu Lys Glu Ile Glu  Ala Glu Lys 
    1310                 1315                 1320             


Val Glu  Leu Glu Leu Lys Val  Ser Ser Thr Thr Ser  Glu Leu Thr 
    1325                 1330                 1335             


Lys Lys  Ser Glu Glu Val Phe  Gln Leu Gln Glu Gln  Ile Asn Lys 
    1340                 1345                 1350             


Gln Gly  Leu Glu Ile Glu Ser  Leu Lys Thr Val Ser  His Glu Ala 
    1355                 1360                 1365             


Glu Val  His Ala Glu Ser Leu  Gln Gln Lys Leu Glu  Ser Ser Gln 
    1370                 1375                 1380             


Leu Gln  Ile Ala Gly Leu Glu  His Leu Arg Glu Leu  Gln Pro Lys 
    1385                 1390                 1395             


Leu Asp  Glu Leu Gln Lys Leu  Ile Ser Lys Lys Glu  Glu Asp Val 
    1400                 1405                 1410             


Ser Tyr  Leu Ser Gly Gln Leu  Ser Glu Lys Glu Ala  Ala Leu Thr 
    1415                 1420                 1425             


Lys Ile  Gln Thr Glu Ile Ile  Glu Gln Glu Asp Leu  Ile Lys Ala 
    1430                 1435                 1440             


Leu His  Thr Gln Leu Glu Met  Gln Ala Lys Glu His  Asp Glu Arg 
    1445                 1450                 1455             


Ile Lys  Gln Leu Gln Val Glu  Leu Cys Glu Met Lys  Gln Lys Pro 
    1460                 1465                 1470             


Glu Glu  Ile Gly Glu Glu Ser  Arg Ala Lys Gln Gln  Ile Gln Arg 
    1475                 1480                 1485             


Lys Leu  Gln Ala Ala Leu Ile  Ser Arg Lys Glu Ala  Leu Lys Glu 
    1490                 1495                 1500             


Asn Lys  Ser Leu Gln Glu Glu  Leu Ser Leu Ala Arg  Gly Thr Ile 
    1505                 1510                 1515             


Glu Arg  Leu Thr Lys Ser Leu  Ala Asp Val Glu Ser  Gln Val Ser 
    1520                 1525                 1530             


Ala Gln  Asn Lys Glu Lys Asp  Thr Val Leu Gly Arg  Leu Ala Leu 
    1535                 1540                 1545             


Leu Gln  Glu Glu Arg Asp Lys  Leu Ile Thr Glu Met  Asp Arg Ser 
    1550                 1555                 1560             


Leu Leu  Glu Asn Gln Ser Leu  Ser Ser Ser Cys Glu  Ser Leu Lys 
    1565                 1570                 1575             


Leu Ala  Leu Glu Gly Leu Thr  Glu Asp Lys Glu Lys  Leu Val Lys 
    1580                 1585                 1590             


Glu Ile  Glu Ser Leu Lys Ser  Ser Lys Ile Ala Glu  Ser Thr Glu 
    1595                 1600                 1605             


Trp Gln  Glu Lys His Lys Glu  Leu Gln Lys Glu Tyr  Glu Ile Leu 
    1610                 1615                 1620             


Leu Gln  Ser Tyr Glu Asn Val  Ser Asn Glu Ala Glu  Arg Ile Gln 
    1625                 1630                 1635             


His Val  Val Glu Ala Val Arg  Gln Glu Lys Gln Glu  Leu Tyr Gly 
    1640                 1645                 1650             


Lys Leu  Arg Ser Thr Glu Ala  Asn Lys Lys Glu Thr  Glu Lys Gln 
    1655                 1660                 1665             


Leu Gln  Glu Ala Glu Gln Glu  Met Glu Glu Met Lys  Glu Lys Met 
    1670                 1675                 1680             


Arg Lys  Phe Ala Lys Ser Lys  Gln Gln Lys Ile Leu  Glu Leu Glu 
    1685                 1690                 1695             


Glu Glu  Asn Asp Arg Leu Arg  Ala Glu Val His Pro  Ala Gly Asp 
    1700                 1705                 1710             


Thr Ala  Lys Glu Cys Met Glu  Thr Leu Leu Ser Ser  Asn Ala Ser 
    1715                 1720                 1725             


Met Lys  Glu Glu Leu Glu Arg  Val Lys Met Glu Tyr  Glu Thr Leu 
    1730                 1735                 1740             


Ser Lys  Lys Phe Gln Ser Leu  Met Ser Glu Lys Asp  Ser Leu Ser 
    1745                 1750                 1755             


Glu Glu  Val Gln Asp Leu Lys  His Gln Ile Glu Gly  Asn Val Ser 
    1760                 1765                 1770             


Lys Gln  Ala Asn Leu Glu Ala  Thr Glu Lys His Asp  Asn Gln Thr 
    1775                 1780                 1785             


Asn Val  Thr Glu Glu Gly Thr  Gln Ser Ile Pro Gly  Glu Thr Glu 
    1790                 1795                 1800             


Glu Gln  Asp Ser Leu Ser Met  Ser Thr Arg Pro Thr  Cys Ser Glu 
    1805                 1810                 1815             


Ser Val  Pro Ser Ala Lys Ser  Ala Asn Pro Ala Val  Ser Lys Asp 
    1820                 1825                 1830             


Phe Ser  Ser His Asp Glu Ile  Asn Asn Tyr Leu Gln  Gln Ile Asp 
    1835                 1840                 1845             


Gln Leu  Lys Glu Arg Ile Ala  Gly Leu Glu Glu Glu  Lys Gln Lys 
    1850                 1855                 1860             


Asn Lys  Glu Phe Ser Gln Thr  Leu Glu Asn Glu Lys  Asn Thr Leu 
    1865                 1870                 1875             


Leu Ser  Gln Ile Ser Thr Lys  Asp Gly Glu Leu Lys  Met Leu Gln 
    1880                 1885                 1890             


Glu Glu  Val Thr Lys Met Asn  Leu Leu Asn Gln Gln  Ile Gln Glu 
    1895                 1900                 1905             


Glu Leu  Ser Arg Val Thr Lys  Leu Lys Glu Thr Ala  Glu Glu Glu 
    1910                 1915                 1920             


Lys Asp  Asp Leu Glu Glu Arg  Leu Met Asn Gln Leu  Ala Glu Leu 
    1925                 1930                 1935             


Asn Gly  Ser Ile Gly Asn Tyr  Cys Gln Asp Val Thr  Asp Ala Gln 
    1940                 1945                 1950             


Ile Lys  Asn Glu Leu Leu Glu  Ser Glu Met Lys Asn  Leu Lys Lys 
    1955                 1960                 1965             


Cys Val  Ser Glu Leu Glu Glu  Glu Lys Gln Gln Leu  Val Lys Glu 
    1970                 1975                 1980             


Lys Thr  Lys Val Glu Ser Glu  Ile Arg Lys Glu Tyr  Leu Glu Lys 
    1985                 1990                 1995             


Ile Gln  Gly Ala Gln Lys Glu  Pro Gly Asn Lys Ser  His Ala Lys 
    2000                 2005                 2010             


Glu Leu  Gln Glu Leu Leu Lys  Glu Lys Gln Gln Glu  Val Lys Gln 
    2015                 2020                 2025             


Leu Gln  Lys Asp Cys Ile Arg  Tyr Gln Glu Lys Ile  Ser Ala Leu 
    2030                 2035                 2040             


Glu Arg  Thr Val Lys Ala Leu  Glu Phe Val Gln Thr  Glu Ser Gln 
    2045                 2050                 2055             


Lys Asp  Leu Glu Ile Thr Lys  Glu Asn Leu Ala Gln  Ala Val Glu 
    2060                 2065                 2070             


His Arg  Lys Lys Ala Gln Ala  Glu Leu Ala Ser Phe  Lys Val Leu 
    2075                 2080                 2085             


Leu Asp  Asp Thr Gln Ser Glu  Ala Ala Arg Val Leu  Ala Asp Asn 
    2090                 2095                 2100             


Leu Lys  Leu Lys Lys Glu Leu  Gln Ser Asn Lys Glu  Ser Val Lys 
    2105                 2110                 2115             


Ser Gln  Met Lys Gln Lys Asp  Glu Asp Leu Glu Arg  Arg Leu Glu 
    2120                 2125                 2130             


Gln Ala  Glu Glu Lys His Leu  Lys Glu Lys Lys Asn  Met Gln Glu 
    2135                 2140                 2145             


Lys Leu  Asp Ala Leu Arg Arg  Glu Lys Val His Leu  Glu Glu Thr 
    2150                 2155                 2160             


Ile Gly  Glu Ile Gln Val Thr  Leu Asn Lys Lys Asp  Lys Glu Val 
    2165                 2170                 2175             


Gln Gln  Leu Gln Glu Asn Leu  Asp Ser Thr Val Thr  Gln Leu Ala 
    2180                 2185                 2190             


Ala Phe  Thr Lys Ser Met Ser  Ser Leu Gln Asp Asp  Arg Asp Arg 
    2195                 2200                 2205             


Val Ile  Asp Glu Ala Lys Lys  Trp Glu Arg Lys Phe  Ser Asp Ala 
    2210                 2215                 2220             


Ile Gln  Ser Lys Glu Glu Glu  Ile Arg Leu Lys Glu  Asp Asn Cys 
    2225                 2230                 2235             


Ser Val  Leu Lys Asp Gln Leu  Arg Gln Met Ser Ile  His Met Glu 
    2240                 2245                 2250             


Glu Leu  Lys Ile Asn Ile Ser  Arg Leu Glu His Asp  Lys Gln Ile 
    2255                 2260                 2265             


Trp Glu  Ser Lys Ala Gln Thr  Glu Val Gln Leu Gln  Gln Lys Val 
    2270                 2275                 2280             


Cys Asp  Thr Leu Gln Gly Glu  Asn Lys Glu Leu Leu  Ser Gln Leu 
    2285                 2290                 2295             


Glu Glu  Thr Arg His Leu Tyr  His Ser Ser Gln Asn  Glu Leu Ala 
    2300                 2305                 2310             


Lys Leu  Glu Ser Glu Leu Lys  Ser Leu Lys Asp Gln  Leu Thr Asp 
    2315                 2320                 2325             


Leu Ser  Asn Ser Leu Glu Lys  Cys Lys Glu Gln Lys  Gly Asn Leu 
    2330                 2335                 2340             


Glu Gly  Ile Ile Arg Gln Gln  Glu Ala Asp Ile Gln  Asn Ser Lys 
    2345                 2350                 2355             


Phe Ser  Tyr Glu Gln Leu Glu  Thr Asp Leu Gln Ala  Ser Arg Glu 
    2360                 2365                 2370             


Leu Thr  Ser Arg Leu His Glu  Glu Ile Asn Met Lys  Glu Gln Lys 
    2375                 2380                 2385             


Ile Ile  Ser Leu Leu Ser Gly  Lys Glu Glu Ala Ile  Gln Val Ala 
    2390                 2395                 2400             


Ile Ala  Glu Leu Arg Gln Gln  His Asp Lys Glu Ile  Lys Glu Leu 
    2405                 2410                 2415             


Glu Asn  Leu Leu Ser Gln Glu  Glu Glu Glu Asn Ile  Val Leu Glu 
    2420                 2425                 2430             


Glu Glu  Asn Lys Lys Ala Val  Asp Lys Thr Asn Gln  Leu Met Glu 
    2435                 2440                 2445             


Thr Leu  Lys Thr Ile Lys Lys  Glu Asn Ile Gln Gln  Lys Ala Gln 
    2450                 2455                 2460             


Leu Asp  Ser Phe Val Lys Ser  Met Ser Ser Leu Gln  Asn Asp Arg 
    2465                 2470                 2475             


Asp Arg  Ile Val Gly Asp Tyr  Gln Gln Leu Glu Glu  Arg His Leu 
    2480                 2485                 2490             


Ser Ile  Ile Leu Glu Lys Asp  Gln Leu Ile Gln Glu  Ala Ala Ala 
    2495                 2500                 2505             


Glu Asn  Asn Lys Leu Lys Glu  Glu Ile Arg Gly Leu  Arg Ser His 
    2510                 2515                 2520             


Met Asp  Asp Leu Asn Ser Glu  Asn Ala Lys Leu Asp  Ala Glu Leu 
    2525                 2530                 2535             


Ile Gln  Tyr Arg Glu Asp Leu  Asn Gln Val Ile Thr  Ile Lys Asp 
    2540                 2545                 2550             


Ser Gln  Gln Lys Gln Leu Leu  Glu Val Gln Leu Gln  Gln Asn Lys 
    2555                 2560                 2565             


Glu Leu  Glu Asn Lys Tyr Ala  Lys Leu Glu Glu Lys  Leu Lys Glu 
    2570                 2575                 2580             


Ser Glu  Glu Ala Asn Glu Asp  Leu Arg Arg Ser Phe  Asn Ala Leu 
    2585                 2590                 2595             


Gln Glu  Glu Lys Gln Asp Leu  Ser Lys Glu Ile Glu  Ser Leu Lys 
    2600                 2605                 2610             


Val Ser  Ile Ser Gln Leu Thr  Arg Gln Val Thr Ala  Leu Gln Glu 
    2615                 2620                 2625             


Glu Gly  Thr Leu Gly Leu Tyr  His Ala Gln Leu Lys  Val Lys Glu 
    2630                 2635                 2640             


Glu Glu  Val His Arg Leu Ser  Ala Leu Phe Ser Ser  Ser Gln Lys 
    2645                 2650                 2655             


Arg Ile  Ala Glu Leu Glu Glu  Glu Leu Val Cys Val  Gln Lys Glu 
    2660                 2665                 2670             


Ala Ala  Lys Lys Val Gly Glu  Ile Glu Asp Lys Leu  Lys Lys Glu 
    2675                 2680                 2685             


Leu Lys  His Leu His His Asp  Ala Gly Ile Met Arg  Asn Glu Thr 
    2690                 2695                 2700             


Glu Thr  Ala Glu Glu Arg Val  Ala Glu Leu Ala Arg  Asp Leu Val 
    2705                 2710                 2715             


Glu Met  Glu Gln Lys Leu Leu  Met Val Thr Lys Glu  Asn Lys Gly 
    2720                 2725                 2730             


Leu Thr  Ala Gln Ile Gln Ser  Phe Gly Arg Ser Met  Ser Ser Leu 
    2735                 2740                 2745             


Gln Asn  Ser Arg Asp His Ala  Asn Glu Glu Leu Asp  Glu Leu Lys 
    2750                 2755                 2760             


Arg Lys  Tyr Asp Ala Ser Leu  Lys Glu Leu Ala Gln  Leu Lys Glu 
    2765                 2770                 2775             


Gln Gly  Leu Leu Asn Arg Glu  Arg Asp Ala Leu Leu  Ser Glu Thr 
    2780                 2785                 2790             


Ala Phe  Ser Met Asn Ser Thr  Glu Glu Asn Ser Leu  Ser His Leu 
    2795                 2800                 2805             


Glu Lys  Leu Asn Gln Gln Leu  Leu Ser Lys Asp Glu  Gln Leu Leu 
    2810                 2815                 2820             


His Leu  Ser Ser Gln Leu Glu  Asp Ser Tyr Asn Gln  Val Gln Ser 
    2825                 2830                 2835             


Phe Ser  Lys Ala Met Ala Ser  Leu Gln Asn Glu Arg  Asp His Leu 
    2840                 2845                 2850             


Trp Asn  Glu Leu Glu Lys Phe  Arg Lys Ser Glu Glu  Gly Lys Gln 
    2855                 2860                 2865             


Arg Ser  Ala Ala Gln Pro Ser  Thr Ser Pro Ala Glu  Val Gln Ser 
    2870                 2875                 2880             


Leu Lys  Lys Ala Met Ser Ser  Leu Gln Asn Asp Arg  Asp Arg Leu 
    2885                 2890                 2895             


Leu Lys  Glu Leu Lys Asn Leu  Gln Gln Gln Tyr Leu  Gln Ile Asn 
    2900                 2905                 2910             


Gln Glu  Ile Thr Glu Leu His  Pro Leu Lys Ala Gln  Leu Gln Glu 
    2915                 2920                 2925             


Tyr Gln  Asp Lys Thr Lys Ala  Phe Gln Ile Met Gln  Glu Glu Leu 
    2930                 2935                 2940             


Arg Gln  Glu Asn Leu Ser Trp  Gln His Glu Leu His  Gln Leu Arg 
    2945                 2950                 2955             


Met Glu  Lys Ser Ser Trp Glu  Ile His Glu Arg Arg  Met Lys Glu 
    2960                 2965                 2970             


Gln Tyr  Leu Met Ala Ile Ser  Asp Lys Asp Gln Gln  Leu Ser His 
    2975                 2980                 2985             


Leu Gln  Asn Leu Ile Arg Glu  Leu Arg Ser Ser Ser  Ser Gln Thr 
    2990                 2995                 3000             


Gln Pro  Leu Lys Val Gln Tyr  Gln Arg Gln Ala Ser  Pro Glu Thr 
    3005                 3010                 3015             


Ser Ala  Ser Pro Asp Gly Ser  Gln Asn Leu Val Tyr  Glu Thr Glu 
    3020                 3025                 3030             


Leu Leu  Arg Thr Gln Leu Asn  Asp Ser Leu Lys Glu  Ile His Gln 
    3035                 3040                 3045             


Lys Glu  Leu Arg Ile Gln Gln  Leu Asn Ser Asn Phe  Ser Gln Leu 
    3050                 3055                 3060             


Leu Glu  Glu Lys Asn Thr Leu  Ser Ile Gln Leu Cys  Asp Thr Ser 
    3065                 3070                 3075             


Gln Ser  Leu Arg Glu Asn Gln  Gln His Tyr Gly Asp  Leu Leu Asn 
    3080                 3085                 3090             


His Cys  Ala Val Leu Glu Lys  Gln Val Gln Glu Leu  Gln Ala Val 
    3095                 3100                 3105             


Ser Lys  Glu Lys Gly Pro Leu  Asn Ile Asp Val Ala  Pro Gly Ala 
    3110                 3115                 3120             


Pro Gln  Glu Lys Asn Gly Val  His Arg Lys Ser Asp  Pro Glu Glu 
    3125                 3130                 3135             


Leu Arg  Glu Pro Gln Gln Ser  Phe Ser Glu Ala Gln  Gln Gln Leu 
    3140                 3145                 3150             


Cys Asn  Thr Arg Gln Glu Val  Asn Glu Leu Arg Lys  Leu Leu Glu 
    3155                 3160                 3165             


Glu Glu  Arg Asp Gln Arg Val  Ala Ala Glu Asn Ala  Leu Ser Val 
    3170                 3175                 3180             


Ala Glu  Glu Gln Ile Arg Arg  Leu Glu His Ser Glu  Trp Asp Ser 
    3185                 3190                 3195             


Ser Arg  Thr Pro Ile Ile Gly  Ser Cys Gly Thr Gln  Glu Gln Ala 
    3200                 3205                 3210             


Leu Leu  Ile Asp Leu Thr Ser  Asn Ser Cys Arg Arg  Thr Arg Ser 
    3215                 3220                 3225             


Gly Val  Gly Trp Lys Arg Val  Leu Arg Ser Leu Cys  His Ser Arg 
    3230                 3235                 3240             


Thr Arg  Val Pro Leu Leu Ala  Ala Ile Tyr Phe Leu  Met Ile His 
    3245                 3250                 3255             


Val Leu  Leu Ile Leu Cys Phe  Thr Gly His Leu 
    3260                 3265                 


<210>  4581
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLM1__Homo_sapiens__NP_808800

<400>  4581

Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      


Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          


Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              


Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  


Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  


Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      


Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         


Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             


Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 


Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 


Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     


Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         


Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             


Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 


Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 


Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     


Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         


Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             


Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 


Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 


Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     


Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         


Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             


Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 


Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 


Leu 
    


<210>  4582
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLPH3__Homo_sapiens__NP_071413

<400>  4582

Met Thr Ser Leu Thr Gln Arg Ser Ser Gly Leu Val Gln Arg Arg Thr 
1               5                   10                  15      


Glu Ala Ser Arg Asn Ala Ala Asp Lys Glu Arg Ala Ala Gly Gly Gly 
            20                  25                  30          


Ala Gly Ser Ser Glu Asp Asp Ala Gln Ser Arg Arg Asp Glu Gln Asp 
        35                  40                  45              


Asp Asp Asp Lys Gly Asp Ser Lys Glu Thr Arg Leu Thr Leu Met Glu 
    50                  55                  60                  


Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Gly Tyr Thr Ser Phe 
65                  70                  75                  80  


Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Cys Met Leu Ile Glu 
                85                  90                  95      


Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys Gly Met Arg Arg 
            100                 105                 110         


Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser Asp Ala Pro Thr 
        115                 120                 125             


Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val Lys Glu Thr Gln 
    130                 135                 140                 


Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu Ser Gly Glu Thr 
145                 150                 155                 160 


Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn Val Arg Glu Arg 
                165                 170                 175     


Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr Thr Glu Lys Gln 
            180                 185                 190         


Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu Thr Asn Asn Asn 
        195                 200                 205             


Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala Val Leu Asp Lys 
    210                 215                 220                 


Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu Leu Ala Leu Ile 
225                 230                 235                 240 


Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala Phe Ala Pro Leu 
                245                 250                 255     


Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val Arg Gln Leu Leu 
            260                 265                 270         


Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn Thr Asn Glu Val 
        275                 280                 285             


Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
    290                 295             


<210>  4583
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLT1A__Homo_sapiens__NP_940849

<400>  4583

Met Ile Ser Ile Thr Glu Trp Gln Lys Ile Gly Val Gly Ile Thr Gly 
1               5                   10                  15      


Phe Gly Ile Phe Phe Ile Leu Phe Gly Thr Leu Leu Tyr Phe Asp Ser 
            20                  25                  30          


Val Leu Leu Ala Phe Gly Asn Leu Leu Phe Leu Thr Gly Leu Ser Leu 
        35                  40                  45              


Ile Ile Gly Leu Arg Lys Thr Phe Trp Phe Phe Phe Gln Arg His Lys 
    50                  55                  60                  


Leu Lys Gly Thr Ser Phe Leu Leu Gly Gly Val Val Ile Val Leu Leu 
65                  70                  75                  80  


Arg Trp Pro Leu Leu Gly Met Phe Leu Glu Thr Tyr Gly Phe Phe Ser 
                85                  90                  95      


Leu Phe Lys Gly Phe Phe Pro Val Ala Phe Gly Phe Leu Gly Asn Val 
            100                 105                 110         


Cys Asn Ile Pro Phe Leu Gly Ala Leu Phe Arg Arg Leu Gln Gly Thr 
        115                 120                 125             


Ser Ser Met Val 
    130         


<210>  4584
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOLT1B__Homo_sapiens__NP_057156

<400>  4584

Met Ile Ser Leu Thr Asp Thr Gln Lys Ile Gly Met Gly Leu Thr Gly 
1               5                   10                  15      


Phe Gly Val Phe Phe Leu Phe Phe Gly Met Ile Leu Phe Phe Asp Lys 
            20                  25                  30          


Ala Leu Leu Ala Ile Gly Asn Val Leu Phe Val Ala Gly Leu Ala Phe 
        35                  40                  45              


Val Ile Gly Leu Glu Arg Thr Phe Arg Phe Phe Phe Gln Lys His Lys 
    50                  55                  60                  


Met Lys Ala Thr Gly Phe Phe Leu Gly Gly Val Phe Val Val Leu Ile 
65                  70                  75                  80  


Gly Trp Pro Leu Ile Gly Met Ile Phe Glu Ile Tyr Gly Phe Phe Leu 
                85                  90                  95      


Leu Phe Arg Gly Phe Phe Pro Val Val Val Gly Phe Ile Arg Arg Val 
            100                 105                 110         


Pro Val Leu Gly Ser Leu Leu Asn Leu Pro Gly Ile Arg Ser Phe Val 
        115                 120                 125             


Asp Lys Val Gly Glu Ser Asn Asn Met Val 
    130                 135             


<210>  4585
<211>  2240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GON4L__Homo_sapiens__NP_001269787

<400>  4585

Met Leu Pro Cys Lys Lys Arg Arg Thr Thr Val Thr Glu Ser Leu Gln 
1               5                   10                  15      


His Lys Gly Asn Gln Glu Glu Asn Asn Val Asp Leu Glu Ser Ala Val 
            20                  25                  30          


Lys Pro Glu Ser Asp Gln Val Lys Asp Leu Ser Ser Val Ser Leu Ser 
        35                  40                  45              


Trp Asp Pro Ser His Gly Arg Val Ala Gly Phe Glu Val Gln Ser Leu 
    50                  55                  60                  


Gln Asp Ala Gly Asn Gln Leu Gly Met Glu Asp Thr Ser Leu Ser Ser 
65                  70                  75                  80  


Gly Met Leu Thr Gln Asn Thr Asn Val Pro Ile Leu Glu Gly Val Asp 
                85                  90                  95      


Val Ala Ile Ser Gln Gly Ile Thr Leu Pro Ser Leu Glu Ser Phe His 
            100                 105                 110         


Pro Leu Asn Ile His Ile Gly Lys Gly Lys Leu His Ala Thr Gly Ser 
        115                 120                 125             


Lys Arg Gly Lys Lys Met Thr Leu Arg Pro Gly Pro Val Thr Gln Glu 
    130                 135                 140                 


Asp Arg Cys Asp His Leu Thr Leu Lys Glu Pro Phe Ser Gly Glu Pro 
145                 150                 155                 160 


Ser Glu Glu Val Lys Glu Glu Gly Gly Lys Pro Gln Met Asn Ser Glu 
                165                 170                 175     


Gly Glu Ile Pro Ser Leu Pro Ser Gly Ser Gln Ser Ala Lys Pro Val 
            180                 185                 190         


Ser Gln Pro Arg Lys Ser Thr Gln Pro Asp Val Cys Ala Ser Pro Gln 
        195                 200                 205             


Glu Lys Pro Leu Arg Thr Leu Phe His Gln Pro Glu Glu Glu Ile Glu 
    210                 215                 220                 


Asp Gly Gly Leu Phe Ile Pro Met Glu Glu Gln Asp Asn Glu Glu Ser 
225                 230                 235                 240 


Glu Lys Arg Arg Lys Lys Lys Lys Gly Thr Lys Arg Lys Arg Asp Gly 
                245                 250                 255     


Arg Gly Gln Glu Gly Thr Leu Ala Tyr Asp Leu Lys Leu Asp Asp Met 
            260                 265                 270         


Leu Asp Arg Thr Leu Glu Asp Gly Ala Lys Gln His Asn Leu Thr Ala 
        275                 280                 285             


Val Asn Val Arg Asn Ile Leu His Glu Val Ile Thr Asn Glu His Val 
    290                 295                 300                 


Val Ala Met Met Lys Ala Ala Ile Ser Glu Thr Glu Asp Met Pro Met 
305                 310                 315                 320 


Phe Glu Pro Lys Met Thr Arg Ser Lys Leu Lys Glu Val Val Glu Lys 
                325                 330                 335     


Gly Val Val Ile Pro Thr Trp Asn Ile Ser Pro Ile Lys Lys Ala Asn 
            340                 345                 350         


Glu Ile Lys Pro Pro Gln Phe Val Asp Ile His Leu Glu Glu Asp Asp 
        355                 360                 365             


Ser Ser Asp Glu Glu Tyr Gln Pro Asp Asp Glu Glu Glu Asp Glu Thr 
    370                 375                 380                 


Ala Glu Glu Ser Leu Leu Glu Ser Asp Val Glu Ser Thr Ala Ser Ser 
385                 390                 395                 400 


Pro Arg Gly Ala Lys Lys Ser Arg Leu Arg Gln Ser Ser Glu Met Thr 
                405                 410                 415     


Glu Thr Asp Glu Glu Ser Gly Ile Leu Ser Glu Ala Glu Lys Val Thr 
            420                 425                 430         


Thr Pro Ala Ile Arg His Ile Ser Ala Glu Val Val Pro Met Gly Pro 
        435                 440                 445             


Pro Pro Pro Pro Lys Pro Lys Gln Thr Arg Asp Ser Thr Phe Met Glu 
    450                 455                 460                 


Lys Leu His Ala Val Asp Glu Glu Leu Ala Ser Ser Pro Val Cys Met 
465                 470                 475                 480 


Asp Ser Phe Gln Pro Met Asp Asp Ser Leu Ile Ala Phe Arg Thr Arg 
                485                 490                 495     


Ser Lys Met Pro Leu Lys Asp Val Pro Leu Gly Gln Leu Glu Ala Glu 
            500                 505                 510         


Leu Gln Ala Pro Asp Ile Thr Pro Asp Met Tyr Asp Pro Asn Thr Ala 
        515                 520                 525             


Asp Asp Glu Asp Trp Lys Met Trp Leu Gly Gly Leu Met Asn Asp Asp 
    530                 535                 540                 


Val Gly Asn Glu Asp Glu Ala Asp Asp Asp Asp Asp Pro Glu Tyr Asn 
545                 550                 555                 560 


Phe Leu Glu Asp Leu Asp Glu Pro Asp Thr Glu Asp Phe Arg Thr Asp 
                565                 570                 575     


Arg Ala Val Arg Ile Thr Lys Lys Glu Val Asn Glu Leu Met Glu Glu 
            580                 585                 590         


Leu Phe Glu Thr Phe Gln Asp Glu Met Gly Phe Ser Asn Met Glu Asp 
        595                 600                 605             


Asp Gly Pro Glu Glu Glu Glu Cys Val Ala Glu Pro Arg Pro Asn Phe 
    610                 615                 620                 


Asn Thr Pro Gln Ala Leu Arg Phe Glu Glu Pro Leu Ala Asn Leu Leu 
625                 630                 635                 640 


Asn Glu Gln His Arg Thr Val Lys Glu Leu Phe Glu Gln Leu Lys Met 
                645                 650                 655     


Lys Lys Ser Ser Ala Lys Gln Leu Gln Glu Val Glu Lys Val Lys Pro 
            660                 665                 670         


Gln Ser Glu Lys Val His Gln Thr Leu Ile Leu Asp Pro Ala Gln Arg 
        675                 680                 685             


Lys Arg Leu Gln Gln Gln Met Gln Gln His Val Gln Leu Leu Thr Gln 
    690                 695                 700                 


Ile His Leu Leu Ala Thr Cys Asn Pro Asn Leu Asn Pro Glu Ala Thr 
705                 710                 715                 720 


Thr Thr Arg Ile Phe Leu Lys Glu Leu Gly Thr Phe Ala Gln Ser Ser 
                725                 730                 735     


Ile Ala Leu His His Gln Tyr Asn Pro Lys Phe Gln Thr Leu Phe Gln 
            740                 745                 750         


Pro Cys Asn Leu Met Gly Ala Met Gln Leu Ile Glu Asp Phe Ser Thr 
        755                 760                 765             


His Val Ser Ile Asp Cys Ser Pro His Lys Thr Val Lys Lys Thr Ala 
    770                 775                 780                 


Asn Glu Phe Pro Cys Leu Pro Lys Gln Val Ala Trp Ile Leu Ala Thr 
785                 790                 795                 800 


Ser Lys Val Phe Met Tyr Pro Glu Leu Leu Pro Val Cys Ser Leu Lys 
                805                 810                 815     


Ala Lys Asn Pro Gln Asp Lys Ile Val Phe Thr Lys Ala Glu Asp Asn 
            820                 825                 830         


Leu Leu Ala Leu Gly Leu Lys His Phe Glu Gly Thr Glu Phe Pro Asn 
        835                 840                 845             


Pro Leu Ile Ser Lys Tyr Leu Leu Thr Cys Lys Thr Ala His Gln Leu 
    850                 855                 860                 


Thr Val Arg Ile Lys Asn Leu Asn Met Asn Arg Ala Pro Asp Asn Ile 
865                 870                 875                 880 


Ile Lys Phe Tyr Lys Lys Thr Lys Gln Leu Pro Val Leu Gly Lys Cys 
                885                 890                 895     


Cys Glu Glu Ile Gln Pro His Gln Trp Lys Pro Pro Ile Glu Arg Glu 
            900                 905                 910         


Glu His Arg Leu Pro Phe Trp Leu Lys Ala Ser Leu Pro Ser Ile Gln 
        915                 920                 925             


Glu Glu Leu Arg His Met Ala Asp Gly Ala Arg Glu Val Gly Asn Met 
    930                 935                 940                 


Thr Gly Thr Thr Glu Ile Asn Ser Asp Arg Ser Leu Glu Lys Asp Asn 
945                 950                 955                 960 


Leu Glu Leu Gly Ser Glu Ser Arg Tyr Pro Leu Leu Leu Pro Lys Gly 
                965                 970                 975     


Val Val Leu Lys Leu Lys Pro Val Ala Thr Arg Phe Pro Arg Lys Ala 
            980                 985                 990         


Trp Arg Gln Lys Arg Ser Ser Val  Leu Lys Pro Leu Leu  Ile Gln Pro 
        995                 1000                 1005             


Ser Pro  Ser Leu Gln Pro Ser  Phe Asn Pro Gly Lys  Thr Pro Ala 
    1010                 1015                 1020             


Arg Ser  Thr His Ser Glu Ala  Pro Pro Ser Lys Met  Val Leu Arg 
    1025                 1030                 1035             


Ile Pro  His Pro Ile Gln Pro  Ala Thr Val Leu Gln  Thr Val Pro 
    1040                 1045                 1050             


Gly Val  Pro Pro Leu Gly Val  Ser Gly Gly Glu Ser  Phe Glu Ser 
    1055                 1060                 1065             


Pro Ala  Ala Leu Pro Ala Val  Pro Pro Glu Ala Arg  Thr Ser Phe 
    1070                 1075                 1080             


Pro Leu  Ser Glu Ser Gln Thr  Leu Leu Ser Ser Ala  Pro Val Pro 
    1085                 1090                 1095             


Lys Val  Met Leu Pro Ser Leu  Ala Pro Ser Lys Phe  Arg Lys Pro 
    1100                 1105                 1110             


Tyr Val  Arg Arg Arg Pro Ser  Lys Arg Arg Gly Val  Lys Ala Ser 
    1115                 1120                 1125             


Pro Cys  Met Lys Pro Ala Pro  Val Ile His His Pro  Ala Ser Val 
    1130                 1135                 1140             


Ile Phe  Thr Val Pro Ala Thr  Thr Val Lys Ile Val  Ser Leu Gly 
    1145                 1150                 1155             


Gly Gly  Cys Asn Met Ile Gln  Pro Val Asn Ala Ala  Val Ala Gln 
    1160                 1165                 1170             


Ser Pro  Gln Thr Ile Pro Ile  Thr Thr Leu Leu Val  Asn Pro Thr 
    1175                 1180                 1185             


Ser Phe  Pro Cys Pro Leu Asn  Gln Ser Leu Val Ala  Ser Ser Val 
    1190                 1195                 1200             


Ser Pro  Leu Ile Val Ser Gly  Asn Ser Val Asn Leu  Pro Ile Pro 
    1205                 1210                 1215             


Ser Thr  Pro Glu Asp Lys Ala  His Val Asn Val Asp  Ile Ala Cys 
    1220                 1225                 1230             


Ala Val  Ala Asp Gly Glu Asn  Ala Phe Gln Gly Leu  Glu Pro Lys 
    1235                 1240                 1245             


Leu Glu  Pro Gln Glu Leu Ser  Pro Leu Ser Ala Thr  Val Phe Pro 
    1250                 1255                 1260             


Lys Val  Glu His Ser Pro Gly  Pro Pro Leu Ala Asp  Ala Glu Cys 
    1265                 1270                 1275             


Gln Glu  Gly Leu Ser Glu Asn  Ser Ala Cys Arg Trp  Thr Val Val 
    1280                 1285                 1290             


Lys Thr  Glu Glu Gly Arg Gln  Ala Leu Glu Pro Leu  Pro Gln Gly 
    1295                 1300                 1305             


Ile Gln  Glu Ser Leu Asn Asn  Pro Thr Pro Gly Asp  Leu Glu Glu 
    1310                 1315                 1320             


Ile Val  Lys Met Glu Pro Glu  Glu Ala Arg Glu Glu  Ile Ser Gly 
    1325                 1330                 1335             


Ser Pro  Glu Arg Asp Ile Cys  Asp Asp Ile Lys Val  Glu His Ala 
    1340                 1345                 1350             


Val Glu  Leu Asp Thr Gly Ala  Pro Ser Glu Glu Leu  Ser Ser Ala 
    1355                 1360                 1365             


Gly Glu  Val Thr Lys Gln Thr  Val Leu Gln Lys Glu  Glu Glu Arg 
    1370                 1375                 1380             


Ser Gln  Pro Thr Lys Thr Pro  Ser Ser Ser Gln Glu  Pro Pro Asp 
    1385                 1390                 1395             


Glu Gly  Thr Ser Gly Thr Asp  Val Asn Lys Gly Ser  Ser Lys Asn 
    1400                 1405                 1410             


Ala Leu  Ser Ser Met Asp Pro  Glu Val Arg Leu Ser  Ser Pro Pro 
    1415                 1420                 1425             


Gly Lys  Pro Glu Asp Ser Ser  Ser Val Asp Gly Gln  Ser Val Gly 
    1430                 1435                 1440             


Thr Pro  Val Gly Pro Glu Thr  Gly Gly Glu Lys Asn  Gly Pro Glu 
    1445                 1450                 1455             


Glu Glu  Glu Glu Glu Asp Phe  Asp Asp Leu Thr Gln  Asp Glu Glu 
    1460                 1465                 1470             


Asp Glu  Met Ser Ser Ala Ser  Glu Glu Ser Val Leu  Ser Val Pro 
    1475                 1480                 1485             


Glu Leu  Gln Glu Thr Met Glu  Lys Leu Thr Trp Leu  Ala Ser Glu 
    1490                 1495                 1500             


Arg Arg  Met Ser Gln Glu Gly  Glu Ser Glu Glu Glu  Asn Ser Gln 
    1505                 1510                 1515             


Glu Glu  Asn Ser Glu Pro Glu  Glu Glu Glu Glu Glu  Glu Ala Glu 
    1520                 1525                 1530             


Gly Met  Glu Ser Leu Gln Lys  Glu Asp Glu Met Thr  Asp Glu Ala 
    1535                 1540                 1545             


Val Gly  Asp Ser Ala Glu Lys  Pro Pro Thr Phe Ala  Ser Pro Glu 
    1550                 1555                 1560             


Thr Ala  Pro Glu Val Glu Thr  Ser Arg Thr Pro Pro  Gly Glu Ser 
    1565                 1570                 1575             


Ile Lys  Ala Ala Gly Lys Gly  Arg Asn Asn His Arg  Ala Arg Asn 
    1580                 1585                 1590             


Lys Arg  Gly Ser Arg Ala Arg  Ala Ser Lys Asp Thr  Ser Lys Leu 
    1595                 1600                 1605             


Leu Leu  Leu Tyr Asp Glu Asp  Ile Leu Glu Arg Asp  Pro Leu Arg 
    1610                 1615                 1620             


Glu Gln  Lys Asp Leu Ala Phe  Ala Gln Ala Tyr Leu  Thr Arg Val 
    1625                 1630                 1635             


Arg Glu  Ala Leu Gln His Ile  Pro Gly Lys Tyr Glu  Asp Phe Leu 
    1640                 1645                 1650             


Gln Val  Ile Tyr Glu Phe Glu  Ser Ser Thr Gln Arg  Arg Thr Ala 
    1655                 1660                 1665             


Val Asp  Leu Tyr Lys Ser Leu  Gln Ile Leu Leu Gln  Asp Trp Pro 
    1670                 1675                 1680             


Gln Leu  Leu Lys Asp Phe Ala  Ala Phe Leu Leu Pro  Glu Gln Ala 
    1685                 1690                 1695             


Leu Ala  Cys Gly Leu Phe Glu  Glu Gln Gln Ala Phe  Glu Lys Ser 
    1700                 1705                 1710             


Arg Lys  Phe Leu Arg Gln Leu  Glu Ile Cys Phe Ala  Glu Asn Pro 
    1715                 1720                 1725             


Ser His  His Gln Lys Ile Ile  Lys Val Leu Gln Gly  Cys Ala Asp 
    1730                 1735                 1740             


Cys Leu  Pro Gln Glu Ile Thr  Glu Leu Lys Thr Gln  Met Trp Gln 
    1745                 1750                 1755             


Leu Leu  Lys Gly His Asp His  Leu Gln Asp Glu Phe  Ser Ile Phe 
    1760                 1765                 1770             


Phe Asp  His Leu Arg Pro Ala  Ala Ser Arg Met Gly  Asp Phe Glu 
    1775                 1780                 1785             


Glu Ile  Asn Trp Thr Glu Glu  Lys Glu Tyr Glu Phe  Asp Gly Phe 
    1790                 1795                 1800             


Glu Glu  Val Ala Leu Pro Asp  Val Glu Glu Glu Glu  Glu Pro Pro 
    1805                 1810                 1815             


Lys Ile  Pro Thr Ala Ser Lys  Asn Lys Arg Lys Lys  Glu Ile Gly 
    1820                 1825                 1830             


Val Gln  Asn His Asp Lys Glu  Thr Glu Trp Pro Asp  Gly Ala Lys 
    1835                 1840                 1845             


Asp Cys  Ala Cys Ser Cys His  Glu Gly Gly Pro Asp  Ser Lys Leu 
    1850                 1855                 1860             


Lys Lys  Ser Lys Arg Arg Ser  Cys Ser His Cys Ser  Ser Lys Val 
    1865                 1870                 1875             


Cys Asp  Ser Lys Ser Tyr Lys  Ser Lys Glu Pro His  Glu Leu Val 
    1880                 1885                 1890             


Gly Ser  Ser Pro His Arg Glu  Ala Ser Pro Met Pro  Gly Ala Lys 
    1895                 1900                 1905             


Glu Ala  Gly Gln Gly Lys Asp  Met Met Glu Glu Glu  Ala Pro Glu 
    1910                 1915                 1920             


Glu Arg  Glu Ser Thr Glu Ala  Thr Gln Ser Arg Thr  Val Arg Thr 
    1925                 1930                 1935             


Thr Arg  Lys Gly Glu Met Pro  Val Ser Gly Leu Ala  Val Gly Ser 
    1940                 1945                 1950             


Thr Leu  Pro Ser Pro Arg Glu  Val Thr Val Thr Glu  Arg Leu Leu 
    1955                 1960                 1965             


Leu Asp  Gly Pro Pro Pro His  Ser Pro Glu Thr Pro  Gln Phe Pro 
    1970                 1975                 1980             


Pro Thr  Thr Gly Ala Val Leu  Tyr Thr Val Lys Arg  Asn Gln Val 
    1985                 1990                 1995             


Gly Pro  Glu Val Arg Ser Cys  Pro Lys Ala Ser Pro  Arg Leu Gln 
    2000                 2005                 2010             


Lys Glu  Arg Glu Gly Gln Lys  Ala Val Ser Glu Ser  Glu Ala Leu 
    2015                 2020                 2025             


Met Leu  Val Trp Asp Ala Ser  Glu Thr Glu Lys Leu  Pro Gly Thr 
    2030                 2035                 2040             


Val Glu  Pro Pro Ala Ser Phe  Leu Ser Pro Val Ser  Ser Lys Thr 
    2045                 2050                 2055             


Arg Asp  Ala Gly Arg Arg His  Val Ser Gly Lys Pro  Asp Thr Gln 
    2060                 2065                 2070             


Glu Arg  Trp Leu Pro Ser Ser  Arg Ala Arg Val Lys  Thr Arg Asp 
    2075                 2080                 2085             


Arg Thr  Cys Pro Val His Glu  Ser Pro Ser Gly Ile  Asp Thr Ser 
    2090                 2095                 2100             


Glu Thr  Ser Pro Lys Ala Pro  Arg Gly Gly Leu Ala  Lys Asp Ser 
    2105                 2110                 2115             


Gly Thr  Gln Ala Lys Gly Pro  Glu Gly Glu Gln Gln  Pro Lys Ala 
    2120                 2125                 2130             


Ala Glu  Ala Thr Val Cys Ala  Asn Asn Ser Lys Val  Ser Ser Thr 
    2135                 2140                 2145             


Gly Glu  Lys Val Val Leu Trp  Thr Arg Glu Ala Asp  Arg Val Ile 
    2150                 2155                 2160             


Leu Thr  Met Cys Gln Glu Gln  Gly Ala Gln Pro Gln  Thr Phe Asn 
    2165                 2170                 2175             


Ile Ile  Ser Gln Gln Leu Gly  Asn Lys Thr Pro Ala  Glu Val Ser 
    2180                 2185                 2190             


His Arg  Phe Arg Glu Leu Met  Gln Leu Phe His Thr  Ala Cys Glu 
    2195                 2200                 2205             


Ala Ser  Ser Glu Asp Glu Asp  Asp Ala Thr Ser Thr  Ser Asn Ala 
    2210                 2215                 2220             


Asp Gln  Leu Ser Asp His Gly  Asp Leu Leu Ser Glu  Glu Glu Leu 
    2225                 2230                 2235             


Asp Glu  
    2240 


<210>  4586
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOPC__Homo_sapiens__NP_001017408

<400>  4586

Met Ser Ala Gly Gly Pro Cys Pro Ala Ala Ala Gly Gly Gly Pro Gly 
1               5                   10                  15      


Gly Ala Ser Cys Ser Val Gly Ala Pro Gly Gly Val Ser Met Phe Arg 
            20                  25                  30          


Trp Leu Glu Val Leu Glu Lys Glu Phe Asp Lys Ala Phe Val Asp Val 
        35                  40                  45              


Asp Leu Leu Leu Gly Glu Ile Asp Pro Asp Gln Ala Asp Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Arg Gln Lys Met Thr Ser Leu Ser Ser Cys Phe Ala Gln Leu 
65                  70                  75                  80  


Cys His Lys Ala Gln Ser Val Ser Gln Ile Asn His Lys Leu Glu Ala 
                85                  90                  95      


Gln Leu Val Asp Leu Lys Ser Glu Leu Thr Glu Thr Gln Ala Glu Lys 
            100                 105                 110         


Val Val Leu Glu Lys Glu Val His Asp Gln Leu Leu Gln Leu His Ser 
        115                 120                 125             


Ile Gln Leu Gln Leu His Ala Lys Thr Gly Gln Ser Ala Asp Ser Gly 
    130                 135                 140                 


Thr Ile Lys Ala Lys Leu Glu Arg Glu Leu Glu Ala Asn Lys Lys Glu 
145                 150                 155                 160 


Lys Met Lys Glu Ala Gln Leu Glu Ala Glu Val Lys Leu Leu Arg Lys 
                165                 170                 175     


Glu Asn Glu Ala Leu Arg Arg His Ile Ala Val Leu Gln Ala Glu Val 
            180                 185                 190         


Tyr Gly Ala Arg Leu Ala Ala Lys Tyr Leu Asp Lys Glu Leu Ala Gly 
        195                 200                 205             


Arg Val Gln Gln Ile Gln Leu Leu Gly Arg Asp Met Lys Gly Pro Ala 
    210                 215                 220                 


His Asp Lys Leu Trp Asn Gln Leu Glu Ala Glu Ile His Leu His Arg 
225                 230                 235                 240 


His Lys Thr Val Ile Arg Ala Cys Arg Gly Arg Asn Asp Leu Lys Arg 
                245                 250                 255     


Pro Met Gln Ala Pro Pro Gly His Asp Gln Asp Ser Leu Lys Lys Ser 
            260                 265                 270         


Gln Gly Val Gly Pro Ile Arg Lys Val Leu Leu Leu Lys Glu Asp His 
        275                 280                 285             


Glu Gly Leu Gly Ile Ser Ile Thr Gly Gly Lys Glu His Gly Val Pro 
    290                 295                 300                 


Ile Leu Ile Ser Glu Ile His Pro Gly Gln Pro Ala Asp Arg Cys Gly 
305                 310                 315                 320 


Gly Leu His Val Gly Asp Ala Ile Leu Ala Val Asn Gly Val Asn Leu 
                325                 330                 335     


Arg Asp Thr Lys His Lys Glu Ala Val Thr Ile Leu Ser Gln Gln Arg 
            340                 345                 350         


Gly Glu Ile Glu Phe Glu Val Val Tyr Val Ala Pro Glu Val Asp Ser 
        355                 360                 365             


Asp Asp Glu Asn Val Glu Tyr Glu Asp Glu Ser Gly His Arg Tyr Arg 
    370                 375                 380                 


Leu Tyr Leu Asp Glu Leu Glu Gly Gly Gly Asn Pro Gly Ala Ser Cys 
385                 390                 395                 400 


Lys Asp Thr Ser Gly Glu Ile Lys Val Leu Gln Gly Phe Asn Lys Lys 
                405                 410                 415     


Ala Val Thr Asp Thr His Glu Asn Gly Asp Leu Gly Thr Ala Ser Glu 
            420                 425                 430         


Thr Pro Leu Asp Asp Gly Ala Ser Lys Leu Asp Asp Leu His Thr Leu 
        435                 440                 445             


Tyr His Lys Lys Ser Tyr 
    450                 


<210>  4587
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GORAB__Homo_sapiens__NP_001139511

<400>  4587

Met Ser Trp Ala Ala Val Leu Ala Val Ala Ala Ala Arg Phe Gly His 
1               5                   10                  15      


Phe Trp Gly Cys Arg Trp Pro Gly Pro Met Ala Gln Gly Trp Ala Gly 
            20                  25                  30          


Phe Ser Glu Glu Glu Leu Arg Arg Leu Lys Gln Thr Lys Asp Pro Phe 
        35                  40                  45              


Glu Pro Gln Arg Arg Leu Pro Ala Lys Lys Ser Arg Gln Gln Leu Gln 
    50                  55                  60                  


Arg Glu Lys Ala Leu Val Glu Gln Ser Gln Lys Leu Gly Leu Gln Asp 
65                  70                  75                  80  


Gly Ser Thr Ser Leu Leu Pro Glu Gln Leu Leu Ser Ala Pro Lys Gln 
                85                  90                  95      


Arg Val Asn Val Gln Lys Pro Pro Phe Ser Ser Pro Thr Leu Pro Ser 
            100                 105                 110         


His Phe Thr Leu Thr Ser Pro Val Gly Asp Gly Gln Pro Gln Gly Ile 
        115                 120                 125             


Glu Ser Gln Pro Lys Glu Leu Gly Leu Glu Asn Ser His Asp Gly His 
    130                 135                 140                 


Asn Asn Val Glu Ile Leu Pro Pro Lys Pro Asp Cys Lys Leu Glu Lys 
145                 150                 155                 160 


Lys Lys Val Glu Leu Gln Glu Lys Ser Arg Trp Glu Val Leu Gln Gln 
                165                 170                 175     


Glu Gln Arg Leu Met Glu Glu Lys Asn Lys Arg Lys Lys Ala Leu Leu 
            180                 185                 190         


Ala Lys Ala Ile Ala Glu Arg Ser Lys Arg Thr Gln Ala Glu Thr Met 
        195                 200                 205             


Lys Leu Lys Arg Ile Gln Lys Glu Leu Gln Ala Leu Asp Asp Met Val 
    210                 215                 220                 


Ser Ala Asp Ile Gly Ile Leu Arg Asn Arg Ile Asp Gln Ala Ser Leu 
225                 230                 235                 240 


Asp Tyr Ser Tyr Ala Arg 
                245     


<210>  4588
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GORASP1__Homo_sapiens__NP_114105

<400>  4588

Met Gly Leu Gly Val Ser Ala Glu Gln Pro Ala Gly Gly Ala Glu Gly 
1               5                   10                  15      


Phe His Leu His Gly Val Gln Glu Asn Ser Pro Ala Gln Gln Ala Gly 
            20                  25                  30          


Leu Glu Pro Tyr Phe Asp Phe Ile Ile Thr Ile Gly His Ser Arg Leu 
        35                  40                  45              


Asn Lys Glu Asn Asp Thr Leu Lys Ala Leu Leu Lys Ala Asn Val Glu 
    50                  55                  60                  


Lys Pro Val Lys Leu Glu Val Phe Asn Met Lys Thr Met Arg Val Arg 
65                  70                  75                  80  


Glu Val Glu Val Val Pro Ser Asn Met Trp Gly Gly Gln Gly Leu Leu 
                85                  90                  95      


Gly Ala Ser Val Arg Phe Cys Ser Phe Arg Arg Ala Ser Glu Gln Val 
            100                 105                 110         


Trp His Val Leu Asp Val Glu Pro Ser Ser Pro Ala Ala Leu Ala Gly 
        115                 120                 125             


Leu Arg Pro Tyr Thr Asp Tyr Val Val Gly Ser Asp Gln Ile Leu Gln 
    130                 135                 140                 


Glu Ser Glu Asp Phe Phe Thr Leu Ile Glu Ser His Glu Gly Lys Pro 
145                 150                 155                 160 


Leu Lys Leu Met Val Tyr Asn Ser Lys Ser Asp Ser Cys Arg Glu Val 
                165                 170                 175     


Thr Val Thr Pro Asn Ala Ala Trp Gly Gly Glu Gly Ser Leu Gly Cys 
            180                 185                 190         


Gly Ile Gly Tyr Gly Tyr Leu His Arg Ile Pro Thr Gln Pro Pro Ser 
        195                 200                 205             


Tyr His Lys Lys Pro Pro Gly Thr Pro Pro Pro Ser Ala Leu Pro Leu 
    210                 215                 220                 


Gly Ala Pro Pro Pro Asp Ala Leu Pro Pro Gly Pro Thr Pro Glu Asp 
225                 230                 235                 240 


Ser Pro Ser Leu Glu Thr Gly Ser Arg Gln Ser Asp Tyr Met Glu Ala 
                245                 250                 255     


Leu Leu Gln Ala Pro Gly Ser Ser Met Glu Asp Pro Leu Pro Gly Pro 
            260                 265                 270         


Gly Ser Pro Ser His Ser Ala Pro Asp Pro Asp Gly Leu Pro His Phe 
        275                 280                 285             


Met Glu Thr Pro Leu Gln Pro Pro Pro Pro Val Gln Arg Val Met Asp 
    290                 295                 300                 


Pro Gly Phe Leu Asp Val Ser Gly Ile Ser Leu Leu Asp Asn Ser Asn 
305                 310                 315                 320 


Ala Ser Val Trp Pro Ser Leu Pro Ser Ser Thr Glu Leu Thr Thr Thr 
                325                 330                 335     


Ala Val Ser Thr Ser Gly Pro Glu Asp Ile Cys Ser Ser Ser Ser Ser 
            340                 345                 350         


His Glu Arg Gly Gly Glu Ala Thr Trp Ser Gly Ser Glu Phe Glu Val 
        355                 360                 365             


Ser Phe Leu Asp Ser Pro Gly Ala Gln Ala Gln Ala Asp His Leu Pro 
    370                 375                 380                 


Gln Leu Thr Leu Pro Asp Ser Leu Thr Ser Ala Ala Ser Pro Glu Asp 
385                 390                 395                 400 


Gly Leu Ser Ala Glu Leu Leu Glu Ala Gln Ala Glu Glu Glu Pro Ala 
                405                 410                 415     


Ser Thr Glu Gly Leu Asp Thr Gly Thr Glu Ala Glu Gly Leu Asp Ser 
            420                 425                 430         


Gln Ala Gln Ile Ser Thr Thr Glu 
        435                 440 


<210>  4589
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GORASP2__Homo_sapiens__NP_056345

<400>  4589

Met Gly Ser Ser Gln Ser Val Glu Ile Pro Gly Gly Gly Thr Glu Gly 
1               5                   10                  15      


Tyr His Val Leu Arg Val Gln Glu Asn Ser Pro Gly His Arg Ala Gly 
            20                  25                  30          


Leu Glu Pro Phe Phe Asp Phe Ile Val Ser Ile Asn Gly Ser Arg Leu 
        35                  40                  45              


Asn Lys Asp Asn Asp Thr Leu Lys Asp Leu Leu Lys Ala Asn Val Glu 
    50                  55                  60                  


Lys Pro Val Lys Met Leu Ile Tyr Ser Ser Lys Thr Leu Glu Leu Arg 
65                  70                  75                  80  


Glu Thr Ser Val Thr Pro Ser Asn Leu Trp Gly Gly Gln Gly Leu Leu 
                85                  90                  95      


Gly Val Ser Ile Arg Phe Cys Ser Phe Asp Gly Ala Asn Glu Asn Val 
            100                 105                 110         


Trp His Val Leu Glu Val Glu Ser Asn Ser Pro Ala Ala Leu Ala Gly 
        115                 120                 125             


Leu Arg Pro His Ser Asp Tyr Ile Ile Gly Ala Asp Thr Val Met Asn 
    130                 135                 140                 


Glu Ser Glu Asp Leu Phe Ser Leu Ile Glu Thr His Glu Ala Lys Pro 
145                 150                 155                 160 


Leu Lys Leu Tyr Val Tyr Asn Thr Asp Thr Asp Asn Cys Arg Glu Val 
                165                 170                 175     


Ile Ile Thr Pro Asn Ser Ala Trp Gly Gly Glu Gly Ser Leu Gly Cys 
            180                 185                 190         


Gly Ile Gly Tyr Gly Tyr Leu His Arg Ile Pro Thr Arg Pro Phe Glu 
        195                 200                 205             


Glu Gly Lys Lys Ile Ser Leu Pro Gly Gln Met Ala Gly Thr Pro Ile 
    210                 215                 220                 


Thr Pro Leu Lys Asp Gly Phe Thr Glu Val Gln Leu Ser Ser Val Asn 
225                 230                 235                 240 


Pro Pro Ser Leu Ser Pro Pro Gly Thr Thr Gly Ile Glu Gln Ser Leu 
                245                 250                 255     


Thr Gly Leu Ser Ile Ser Ser Thr Pro Pro Ala Val Ser Ser Val Leu 
            260                 265                 270         


Ser Thr Gly Val Pro Thr Val Pro Leu Leu Pro Pro Gln Val Asn Gln 
        275                 280                 285             


Ser Leu Thr Ser Val Pro Pro Met Asn Pro Ala Thr Thr Leu Pro Gly 
    290                 295                 300                 


Leu Met Pro Leu Pro Ala Gly Leu Pro Asn Leu Pro Asn Leu Asn Leu 
305                 310                 315                 320 


Asn Leu Pro Ala Pro His Ile Met Pro Gly Val Gly Leu Pro Glu Leu 
                325                 330                 335     


Val Asn Pro Gly Leu Pro Pro Leu Pro Ser Met Pro Pro Arg Asn Leu 
            340                 345                 350         


Pro Gly Ile Ala Pro Leu Pro Leu Pro Ser Glu Phe Leu Pro Ser Phe 
        355                 360                 365             


Pro Leu Val Pro Glu Ser Ser Ser Ala Ala Ser Ser Gly Glu Leu Leu 
    370                 375                 380                 


Ser Ser Leu Pro Pro Thr Ser Asn Ala Pro Ser Asp Pro Ala Thr Thr 
385                 390                 395                 400 


Thr Ala Lys Ala Asp Ala Ala Ser Ser Leu Thr Val Asp Val Thr Pro 
                405                 410                 415     


Pro Thr Ala Lys Ala Pro Thr Thr Val Glu Asp Arg Val Gly Asp Ser 
            420                 425                 430         


Thr Pro Val Ser Glu Lys Pro Val Ser Ala Ala Val Asp Ala Asn Ala 
        435                 440                 445             


Ser Glu Ser Pro 
    450         


<210>  4590
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOSR1__Homo_sapiens__NP_001007026

<400>  4590

Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala 
1               5                   10                  15      


Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys 
            20                  25                  30          


Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp 
        35                  40                  45              


Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp Arg Met 
    50                  55                  60                  


Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg Leu Thr 
65                  70                  75                  80  


Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly Val Pro 
                85                  90                  95      


Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg Asp Ile 
            100                 105                 110         


Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn Phe Met 
        115                 120                 125             


Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys Asp Ile 
    130                 135                 140                 


Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr Glu Leu 
145                 150                 155                 160 


Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu Ile Glu 
                165                 170                 175     


Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr Ser Gln 
            180                 185                 190         


Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu Ala Asn 
        195                 200                 205             


Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu Arg Lys 
    210                 215                 220                 


Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys Thr Ile 
225                 230                 235                 240 


Leu Leu Leu Leu Tyr Ala Phe His 
                245             


<210>  4591
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOSR2__Homo_sapiens__NP_001012529

<400>  4591

Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln 
1               5                   10                  15      


Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile 
            20                  25                  30          


Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu 
        35                  40                  45              


Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln 
    50                  55                  60                  


Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu 
65                  70                  75                  80  


Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln 
                85                  90                  95      


Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn 
            100                 105                 110         


Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser 
        115                 120                 125             


Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly 
    130                 135                 140                 


His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Val 
145                 150                 155                 160 


Gly Ser Leu Leu Gly Asp Arg Glu Lys Ala Ser Cys Phe Ser Leu Ile 
                165                 170                 175     


Gln Gln Phe Ser Asn Cys Val Tyr Ile Leu Ile Thr Cys Pro Gln Ile 
            180                 185                 190         


Val Ile Phe 
        195 


<210>  4592
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOT1__Homo_sapiens__NP_002070

<400>  4592

Met Ala Pro Pro Ser Val Phe Ala Glu Val Pro Gln Ala Gln Pro Val 
1               5                   10                  15      


Leu Val Phe Lys Leu Thr Ala Asp Phe Arg Glu Asp Pro Asp Pro Arg 
            20                  25                  30          


Lys Val Asn Leu Gly Val Gly Ala Tyr Arg Thr Asp Asp Cys His Pro 
        35                  40                  45              


Trp Val Leu Pro Val Val Lys Lys Val Glu Gln Lys Ile Ala Asn Asp 
    50                  55                  60                  


Asn Ser Leu Asn His Glu Tyr Leu Pro Ile Leu Gly Leu Ala Glu Phe 
65                  70                  75                  80  


Arg Ser Cys Ala Ser Arg Leu Ala Leu Gly Asp Asp Ser Pro Ala Leu 
                85                  90                  95      


Lys Glu Lys Arg Val Gly Gly Val Gln Ser Leu Gly Gly Thr Gly Ala 
            100                 105                 110         


Leu Arg Ile Gly Ala Asp Phe Leu Ala Arg Trp Tyr Asn Gly Thr Asn 
        115                 120                 125             


Asn Lys Asn Thr Pro Val Tyr Val Ser Ser Pro Thr Trp Glu Asn His 
    130                 135                 140                 


Asn Ala Val Phe Ser Ala Ala Gly Phe Lys Asp Ile Arg Ser Tyr Arg 
145                 150                 155                 160 


Tyr Trp Asp Ala Glu Lys Arg Gly Leu Asp Leu Gln Gly Phe Leu Asn 
                165                 170                 175     


Asp Leu Glu Asn Ala Pro Glu Phe Ser Ile Val Val Leu His Ala Cys 
            180                 185                 190         


Ala His Asn Pro Thr Gly Ile Asp Pro Thr Pro Glu Gln Trp Lys Gln 
        195                 200                 205             


Ile Ala Ser Val Met Lys His Arg Phe Leu Phe Pro Phe Phe Asp Ser 
    210                 215                 220                 


Ala Tyr Gln Gly Phe Ala Ser Gly Asn Leu Glu Arg Asp Ala Trp Ala 
225                 230                 235                 240 


Ile Arg Tyr Phe Val Ser Glu Gly Phe Glu Phe Phe Cys Ala Gln Ser 
                245                 250                 255     


Phe Ser Lys Asn Phe Gly Leu Tyr Asn Glu Arg Val Gly Asn Leu Thr 
            260                 265                 270         


Val Val Gly Lys Glu Pro Glu Ser Ile Leu Gln Val Leu Ser Gln Met 
        275                 280                 285             


Glu Lys Ile Val Arg Ile Thr Trp Ser Asn Pro Pro Ala Gln Gly Ala 
    290                 295                 300                 


Arg Ile Val Ala Ser Thr Leu Ser Asn Pro Glu Leu Phe Glu Glu Trp 
305                 310                 315                 320 


Thr Gly Asn Val Lys Thr Met Ala Asp Arg Ile Leu Thr Met Arg Ser 
                325                 330                 335     


Glu Leu Arg Ala Arg Leu Glu Ala Leu Lys Thr Pro Gly Thr Trp Asn 
            340                 345                 350         


His Ile Thr Asp Gln Ile Gly Met Phe Ser Phe Thr Gly Leu Asn Pro 
        355                 360                 365             


Lys Gln Val Glu Tyr Leu Val Asn Glu Lys His Ile Tyr Leu Leu Pro 
    370                 375                 380                 


Ser Gly Arg Ile Asn Val Ser Gly Leu Thr Thr Lys Asn Leu Asp Tyr 
385                 390                 395                 400 


Val Ala Thr Ser Ile His Glu Ala Val Thr Lys Ile Gln 
                405                 410             


<210>  4593
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GOT2__Homo_sapiens__NP_001273149

<400>  4593

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
1               5                   10                  15      


Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
            20                  25                  30          


Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
        35                  40                  45              


Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
    50                  55                  60                  


Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
65                  70                  75                  80  


Arg Lys Phe Val Thr Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg 
                85                  90                  95      


Ile Gly Ala Ser Phe Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val 
            100                 105                 110         


Phe Leu Pro Lys Pro Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp 
        115                 120                 125             


Ala Gly Met Gln Leu Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys 
    130                 135                 140                 


Gly Phe Asp Phe Thr Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu 
145                 150                 155                 160 


Gln Ser Val Leu Leu Leu His Ala Cys Ala His Asn Pro Thr Gly Val 
                165                 170                 175     


Asp Pro Arg Pro Glu Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys 
            180                 185                 190         


Arg Asn Leu Phe Ala Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser 
        195                 200                 205             


Gly Asp Gly Asp Lys Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln 
    210                 215                 220                 


Gly Ile Asn Val Cys Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu 
225                 230                 235                 240 


Tyr Gly Glu Arg Val Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp 
                245                 250                 255     


Glu Ala Lys Arg Val Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met 
            260                 265                 270         


Tyr Ser Asn Pro Pro Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu 
        275                 280                 285             


Asn Thr Pro Asp Leu Arg Lys Gln Trp Leu Gln Glu Val Lys Val Met 
    290                 295                 300                 


Ala Asp Arg Ile Ile Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys 
305                 310                 315                 320 


Lys Glu Gly Ser Thr His Asn Trp Gln His Ile Thr Asp Gln Ile Gly 
                325                 330                 335     


Met Phe Cys Phe Thr Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile 
            340                 345                 350         


Lys Glu Phe Ser Ile Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala 
        355                 360                 365             


Gly Val Thr Ser Ser Asn Val Gly Tyr Leu Ala His Ala Ile His Gln 
    370                 375                 380                 


Val Thr Lys 
385         


<210>  4594
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP1BA__Homo_sapiens__NP_000164

<400>  4594

Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Pro 
1               5                   10                  15      


His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn 
            20                  25                  30          


Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp 
        35                  40                  45              


Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu 
    50                  55                  60                  


Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg 
65                  70                  75                  80  


Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly 
                85                  90                  95      


Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly 
            100                 105                 110         


Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu 
        115                 120                 125             


Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu 
    130                 135                 140                 


Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu 
145                 150                 155                 160 


Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu 
                165                 170                 175     


Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr 
            180                 185                 190         


Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe 
        195                 200                 205             


Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu 
    210                 215                 220                 


Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala 
225                 230                 235                 240 


Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr 
                245                 250                 255     


Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val 
            260                 265                 270         


Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp 
        275                 280                 285             


Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys 
    290                 295                 300                 


Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala His Thr 
305                 310                 315                 320 


Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu Asp Ser 
                325                 330                 335     


Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys Glu Gln 
            340                 345                 350         


Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His Met Glu 
        355                 360                 365             


Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro Thr Pro 
    370                 375                 380                 


Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn Met Thr 
385                 390                 395                 400 


Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu 
                405                 410                 415     


Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro Ala Pro 
            420                 425                 430         


Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro Ala Pro Ser Pro Thr 
        435                 440                 445             


Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile Ala Thr Ser Pro Thr Ile 
    450                 455                 460                 


Leu Val Ser Ala Thr Ser Leu Ile Thr Pro Lys Ser Thr Phe Leu Thr 
465                 470                 475                 480 


Thr Thr Lys Pro Val Ser Leu Leu Glu Ser Thr Lys Lys Thr Ile Pro 
                485                 490                 495     


Glu Leu Asp Gln Pro Pro Lys Leu Arg Gly Val Leu Gln Gly His Leu 
            500                 505                 510         


Glu Ser Ser Arg Asn Asp Pro Phe Leu His Pro Asp Phe Cys Cys Leu 
        515                 520                 525             


Leu Pro Leu Gly Phe Tyr Val Leu Gly Leu Phe Trp Leu Leu Phe Ala 
    530                 535                 540                 


Ser Val Val Leu Ile Leu Leu Leu Ser Trp Val Gly His Val Lys Pro 
545                 550                 555                 560 


Gln Ala Leu Asp Ser Gly Gln Gly Ala Ala Leu Thr Thr Ala Thr Gln 
                565                 570                 575     


Thr Thr His Leu Glu Leu Gln Arg Gly Arg Gln Val Thr Val Pro Arg 
            580                 585                 590         


Ala Trp Leu Leu Phe Leu Arg Gly Ser Leu Pro Thr Phe Arg Ser Ser 
        595                 600                 605             


Leu Phe Leu Trp Val Arg Pro Asn Gly Arg Val Gly Pro Leu Val Ala 
    610                 615                 620                 


Gly Arg Arg Pro Ser Ala Leu Ser Gln Gly Arg Gly Gln Asp Leu Leu 
625                 630                 635                 640 


Ser Thr Val Ser Ile Arg Tyr Ser Gly His Ser Leu 
                645                 650         


<210>  4595
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP1BB__Homo_sapiens__NP_000398

<400>  4595

Met Gly Ser Gly Pro Arg Gly Ala Leu Ser Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Pro Pro Ser Arg Pro Ala Ala Gly Cys Pro Ala Pro Cys Ser Cys 
            20                  25                  30          


Ala Gly Thr Leu Val Asp Cys Gly Arg Arg Gly Leu Thr Trp Ala Ser 
        35                  40                  45              


Leu Pro Thr Ala Phe Pro Val Asp Thr Thr Glu Leu Val Leu Thr Gly 
    50                  55                  60                  


Asn Asn Leu Thr Ala Leu Pro Pro Gly Leu Leu Asp Ala Leu Pro Ala 
65                  70                  75                  80  


Leu Arg Thr Ala His Leu Gly Ala Asn Pro Trp Arg Cys Asp Cys Arg 
                85                  90                  95      


Leu Val Pro Leu Arg Ala Trp Leu Ala Gly Arg Pro Glu Arg Ala Pro 
            100                 105                 110         


Tyr Arg Asp Leu Arg Cys Val Ala Pro Pro Ala Leu Arg Gly Arg Leu 
        115                 120                 125             


Leu Pro Tyr Leu Ala Glu Asp Glu Leu Arg Ala Ala Cys Ala Pro Gly 
    130                 135                 140                 


Pro Leu Cys Trp Gly Ala Leu Ala Ala Gln Leu Ala Leu Leu Gly Leu 
145                 150                 155                 160 


Gly Leu Leu His Ala Leu Leu Leu Val Leu Leu Leu Cys Arg Leu Arg 
                165                 170                 175     


Arg Leu Arg Ala Arg Ala Arg Ala Arg Ala Ala Ala Arg Leu Ser Leu 
            180                 185                 190         


Thr Asp Pro Leu Val Ala Glu Arg Ala Gly Thr Asp Glu Ser 
        195                 200                 205     


<210>  4596
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP2__Homo_sapiens__NP_001007241

<400>  4596

Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu 
1               5                   10                  15      


Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly 
            20                  25                  30          


Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys 
        35                  40                  45              


Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln 
    50                  55                  60                  


Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala 
65                  70                  75                  80  


Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val 
                85                  90                  95      


Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg 
            100                 105                 110         


Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu 
        115                 120                 125             


Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn 
    130                 135                 140                 


Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly 
145                 150                 155                 160 


Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr 
                165                 170                 175     


Cys Thr Val Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys 
            180                 185                 190         


Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly 
        195                 200                 205             


Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln 
    210                 215                 220                 


Pro Gln Leu Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys 
225                 230                 235                 240 


Cys Leu Leu Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu 
                245                 250                 255     


Arg Asp Pro Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp 
            260                 265                 270         


Val Ser Val Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu 
        275                 280                 285             


Glu Arg Asn Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val 
    290                 295                 300                 


Asn Asp Phe Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys 
305                 310                 315                 320 


Ala Tyr Pro Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro 
                325                 330                 335     


Ile Val Ser Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile 
            340                 345                 350         


Val Arg Met Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu 
        355                 360                 365             


Gly Asp Ala Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala 
    370                 375                 380                 


Ile Leu Glu Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn 
385                 390                 395                 400 


Cys Tyr Ala Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe 
                405                 410                 415     


Ile Ile Arg Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val 
            420                 425                 430         


Glu Glu Asn Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe 
        435                 440                 445             


Met Phe Ala Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His 
    450                 455                 460                 


Leu Cys Asp Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser 
465                 470                 475                 480 


Gln Val Arg Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp 
                485                 490                 495     


Leu Gly Pro Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn 
            500                 505                 510         


Gly Thr Pro Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu 
        515                 520                 525             


Leu Thr Val Leu Leu Ala Trp Leu Phe 
    530                 535         


<210>  4597
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP5__Homo_sapiens__NP_004479

<400>  4597

Met Leu Arg Gly Thr Leu Leu Cys Ala Val Leu Gly Leu Leu Arg Ala 
1               5                   10                  15      


Gln Pro Phe Pro Cys Pro Pro Ala Cys Lys Cys Val Phe Arg Asp Ala 
            20                  25                  30          


Ala Gln Cys Ser Gly Gly Asp Val Ala Arg Ile Ser Ala Leu Gly Leu 
        35                  40                  45              


Pro Thr Asn Leu Thr His Ile Leu Leu Phe Gly Met Gly Arg Gly Val 
    50                  55                  60                  


Leu Gln Ser Gln Ser Phe Ser Gly Met Thr Val Leu Gln Arg Leu Met 
65                  70                  75                  80  


Ile Ser Asp Ser His Ile Ser Ala Val Ala Pro Gly Thr Phe Ser Asp 
                85                  90                  95      


Leu Ile Lys Leu Lys Thr Leu Arg Leu Ser Arg Asn Lys Ile Thr His 
            100                 105                 110         


Leu Pro Gly Ala Leu Leu Asp Lys Met Val Leu Leu Glu Gln Leu Phe 
        115                 120                 125             


Leu Asp His Asn Ala Leu Arg Gly Ile Asp Gln Asn Met Phe Gln Lys 
    130                 135                 140                 


Leu Val Asn Leu Gln Glu Leu Ala Leu Asn Gln Asn Gln Leu Asp Phe 
145                 150                 155                 160 


Leu Pro Ala Ser Leu Phe Thr Asn Leu Glu Asn Leu Lys Leu Leu Asp 
                165                 170                 175     


Leu Ser Gly Asn Asn Leu Thr His Leu Pro Lys Gly Leu Leu Gly Ala 
            180                 185                 190         


Gln Ala Lys Leu Glu Arg Leu Leu Leu His Ser Asn Arg Leu Val Ser 
        195                 200                 205             


Leu Asp Ser Gly Leu Leu Asn Ser Leu Gly Ala Leu Thr Glu Leu Gln 
    210                 215                 220                 


Phe His Arg Asn His Ile Arg Ser Ile Ala Pro Gly Ala Phe Asp Arg 
225                 230                 235                 240 


Leu Pro Asn Leu Ser Ser Leu Thr Leu Ser Arg Asn His Leu Ala Phe 
                245                 250                 255     


Leu Pro Ser Ala Leu Phe Leu His Ser His Asn Leu Thr Leu Leu Thr 
            260                 265                 270         


Leu Phe Glu Asn Pro Leu Ala Glu Leu Pro Gly Val Leu Phe Gly Glu 
        275                 280                 285             


Met Gly Gly Leu Gln Glu Leu Trp Leu Asn Arg Thr Gln Leu Arg Thr 
    290                 295                 300                 


Leu Pro Ala Ala Ala Phe Arg Asn Leu Ser Arg Leu Arg Tyr Leu Gly 
305                 310                 315                 320 


Val Thr Leu Ser Pro Arg Leu Ser Ala Leu Pro Gln Gly Ala Phe Gln 
                325                 330                 335     


Gly Leu Gly Glu Leu Gln Val Leu Ala Leu His Ser Asn Gly Leu Thr 
            340                 345                 350         


Ala Leu Pro Asp Gly Leu Leu Arg Gly Leu Gly Lys Leu Arg Gln Val 
        355                 360                 365             


Ser Leu Arg Arg Asn Arg Leu Arg Ala Leu Pro Arg Ala Leu Phe Arg 
    370                 375                 380                 


Asn Leu Ser Ser Leu Glu Ser Val Gln Leu Asp His Asn Gln Leu Glu 
385                 390                 395                 400 


Thr Leu Pro Gly Asp Val Phe Gly Ala Leu Pro Arg Leu Thr Glu Val 
                405                 410                 415     


Leu Leu Gly His Asn Ser Trp Arg Cys Asp Cys Gly Leu Gly Pro Phe 
            420                 425                 430         


Leu Gly Trp Leu Arg Gln His Leu Gly Leu Val Gly Gly Glu Glu Pro 
        435                 440                 445             


Pro Arg Cys Ala Gly Pro Gly Ala His Ala Gly Leu Pro Leu Trp Ala 
    450                 455                 460                 


Leu Pro Gly Gly Asp Ala Glu Cys Pro Gly Pro Arg Gly Pro Pro Pro 
465                 470                 475                 480 


Arg Pro Ala Ala Asp Ser Ser Ser Glu Ala Pro Val His Pro Ala Leu 
                485                 490                 495     


Ala Pro Asn Ser Ser Glu Pro Trp Val Trp Ala Gln Pro Val Thr Thr 
            500                 505                 510         


Gly Lys Gly Gln Asp His Ser Pro Phe Trp Gly Phe Tyr Phe Leu Leu 
        515                 520                 525             


Leu Ala Val Gln Ala Met Ile Thr Val Ile Ile Val Phe Ala Met Ile 
    530                 535                 540                 


Lys Ile Gly Gln Leu Phe Arg Lys Leu Ile Arg Glu Arg Ala Leu Gly 
545                 550                 555                 560 


<210>  4598
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP6__Homo_sapiens__NP_001077368

<400>  4598

Met Ser Pro Ser Pro Thr Ala Leu Phe Cys Leu Gly Leu Cys Leu Gly 
1               5                   10                  15      


Arg Val Pro Ala Gln Ser Gly Pro Leu Pro Lys Pro Ser Leu Gln Ala 
            20                  25                  30          


Leu Pro Ser Ser Leu Val Pro Leu Glu Lys Pro Val Thr Leu Arg Cys 
        35                  40                  45              


Gln Gly Pro Pro Gly Val Asp Leu Tyr Arg Leu Glu Lys Leu Ser Ser 
    50                  55                  60                  


Ser Arg Tyr Gln Asp Gln Ala Val Leu Phe Ile Pro Ala Met Lys Arg 
65                  70                  75                  80  


Ser Leu Ala Gly Arg Tyr Arg Cys Ser Tyr Gln Asn Gly Ser Leu Trp 
                85                  90                  95      


Ser Leu Pro Ser Asp Gln Leu Glu Leu Val Ala Thr Gly Val Phe Ala 
            100                 105                 110         


Lys Pro Ser Leu Ser Ala Gln Pro Gly Pro Ala Val Ser Ser Gly Gly 
        115                 120                 125             


Asp Val Thr Leu Gln Cys Gln Thr Arg Tyr Gly Phe Asp Gln Phe Ala 
    130                 135                 140                 


Leu Tyr Lys Glu Gly Asp Pro Ala Pro Tyr Lys Asn Pro Glu Arg Trp 
145                 150                 155                 160 


Tyr Arg Ala Ser Phe Pro Ile Ile Thr Val Thr Ala Ala His Ser Gly 
                165                 170                 175     


Thr Tyr Arg Cys Tyr Ser Phe Ser Ser Arg Asp Pro Tyr Leu Trp Ser 
            180                 185                 190         


Ala Pro Ser Asp Pro Leu Glu Leu Val Val Thr Gly Thr Ser Val Thr 
        195                 200                 205             


Pro Ser Arg Leu Pro Thr Glu Pro Pro Ser Pro Val Ala Glu Phe Ser 
    210                 215                 220                 


Glu Ala Thr Ala Glu Leu Thr Val Ser Phe Thr Asn Glu Val Phe Thr 
225                 230                 235                 240 


Thr Glu Thr Ser Arg Ser Ile Thr Ala Ser Pro Lys Glu Ser Asp Ser 
                245                 250                 255     


Pro Ala Gly Glu Ser Cys Pro Pro Val Leu His Gln Gly Gln Pro Gly 
            260                 265                 270         


Pro Asp Met Pro Arg Gly Cys Asp Pro Asn Asn Pro Gly Gly Val Ser 
        275                 280                 285             


Gly Arg Gly Leu Ala Gln Pro Glu Glu Ala Pro Ala Ala Gln Gly Gln 
    290                 295                 300                 


Gly Cys Ala Glu Ala Ala Ser Ala Pro Pro Ala Pro Pro Ala Asp Pro 
305                 310                 315                 320 


Glu Ile Lys Arg Gly Ser Gly Trp Arg Pro Thr Gly Cys Ser Gln Pro 
                325                 330                 335     


Arg Val Met Phe Met Thr Ala Glu Pro Gln Ala Arg Ser Tyr Pro Arg 
            340                 345                 350         


Glu Gly Ser Trp His Gly Arg Arg Leu Lys Asp Trp Arg Val Trp Ser 
        355                 360                 365             


Val Glu Ala Gly Gly Gln Arg Leu Gln Leu Trp Lys Arg Gly His Ala 
    370                 375                 380                 


Ala Ser Ser Trp Cys Ser Ile Arg Glu Pro Phe Gly Gln Cys Leu Ser 
385                 390                 395                 400 


Val Cys Leu Pro Leu Cys Leu Arg Ala Pro Ser Ile Trp Asp Gly Arg 
                405                 410                 415     


Asn Leu Trp Arg Pro His Pro Pro Pro Cys Thr Leu Trp Met Thr Trp 
            420                 425                 430         


Tyr Pro Gly Trp Thr Thr Tyr Trp Pro Leu Ser Ser Thr Ser Leu Ile 
        435                 440                 445             


Trp Ala Pro Asp Gly Ser Leu Arg Phe Pro Ala Leu Arg Val Asp Ser 
    450                 455                 460                 


Val Pro Ser Ser Val Gln Asn Pro Pro Val Leu Pro Phe Gly Pro Leu 
465                 470                 475                 480 


Cys Ser Cys Leu Val Phe Pro Arg Asn Ser His Pro His Ser Ile Ser 
                485                 490                 495     


His Cys Gly Leu Thr Asn Leu Leu Ser Ser Leu Arg Thr Gly Leu Ala 
            500                 505                 510         


Gly Ser Leu Gly Met Ser Phe Ile Phe Leu Ser Val Lys Leu Ala Arg 
        515                 520                 525             


Cys Pro Leu Pro Phe Thr Leu Glu Asn Lys Ile Ser Leu Cys Asn Met 
    530                 535                 540                 


Val Lys Pro His Leu Tyr Gln Gln Asn Lys Lys Thr Gln Lys Leu Ala 
545                 550                 555                 560 


Arg Cys Gly Gly Ala Ser Leu Tyr Ser Gln Gln Leu Arg Gly Leu Arg 
                565                 570                 575     


Trp Glu Asn Gly Leu Ser Leu Gly Gly Arg Gly Cys Ser Glu Leu Arg 
            580                 585                 590         


Ser His His Cys Thr Leu Ala Arg Val Thr Lys Pro Asp Phe Val Ser 
        595                 600                 605             


Lys Asn Thr Gly Met Asn Met Ser Ile Thr Leu Ile 
    610                 615                 620 


<210>  4599
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GP9__Homo_sapiens__NP_000165

<400>  4599

Met Pro Ala Trp Gly Ala Leu Phe Leu Leu Trp Ala Thr Ala Glu Ala 
1               5                   10                  15      


Thr Lys Asp Cys Pro Ser Pro Cys Thr Cys Arg Ala Leu Glu Thr Met 
            20                  25                  30          


Gly Leu Trp Val Asp Cys Arg Gly His Gly Leu Thr Ala Leu Pro Ala 
        35                  40                  45              


Leu Pro Ala Arg Thr Arg His Leu Leu Leu Ala Asn Asn Ser Leu Gln 
    50                  55                  60                  


Ser Val Pro Pro Gly Ala Phe Asp His Leu Pro Gln Leu Gln Thr Leu 
65                  70                  75                  80  


Asp Val Thr Gln Asn Pro Trp His Cys Asp Cys Ser Leu Thr Tyr Leu 
                85                  90                  95      


Arg Leu Trp Leu Glu Asp Arg Thr Pro Glu Ala Leu Leu Gln Val Arg 
            100                 105                 110         


Cys Ala Ser Pro Ser Leu Ala Ala His Gly Pro Leu Gly Arg Leu Thr 
        115                 120                 125             


Gly Tyr Gln Leu Gly Ser Cys Gly Trp Gln Leu Gln Ala Ser Trp Val 
    130                 135                 140                 


Arg Pro Gly Val Leu Trp Asp Val Ala Leu Val Ala Val Ala Ala Leu 
145                 150                 155                 160 


Gly Leu Ala Leu Leu Ala Gly Leu Leu Cys Ala Thr Thr Glu Ala Leu 
                165                 170                 175     


Asp 
    


<210>  4600
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPA33__Homo_sapiens__NP_005805

<400>  4600

Met Val Gly Lys Met Trp Pro Val Leu Trp Thr Leu Cys Ala Val Arg 
1               5                   10                  15      


Val Thr Val Asp Ala Ile Ser Val Glu Thr Pro Gln Asp Val Leu Arg 
            20                  25                  30          


Ala Ser Gln Gly Lys Ser Val Thr Leu Pro Cys Thr Tyr His Thr Ser 
        35                  40                  45              


Thr Ser Ser Arg Glu Gly Leu Ile Gln Trp Asp Lys Leu Leu Leu Thr 
    50                  55                  60                  


His Thr Glu Arg Val Val Ile Trp Pro Phe Ser Asn Lys Asn Tyr Ile 
65                  70                  75                  80  


His Gly Glu Leu Tyr Lys Asn Arg Val Ser Ile Ser Asn Asn Ala Glu 
                85                  90                  95      


Gln Ser Asp Ala Ser Ile Thr Ile Asp Gln Leu Thr Met Ala Asp Asn 
            100                 105                 110         


Gly Thr Tyr Glu Cys Ser Val Ser Leu Met Ser Asp Leu Glu Gly Asn 
        115                 120                 125             


Thr Lys Ser Arg Val Arg Leu Leu Val Leu Val Pro Pro Ser Lys Pro 
    130                 135                 140                 


Glu Cys Gly Ile Glu Gly Glu Thr Ile Ile Gly Asn Asn Ile Gln Leu 
145                 150                 155                 160 


Thr Cys Gln Ser Lys Glu Gly Ser Pro Thr Pro Gln Tyr Ser Trp Lys 
                165                 170                 175     


Arg Tyr Asn Ile Leu Asn Gln Glu Gln Pro Leu Ala Gln Pro Ala Ser 
            180                 185                 190         


Gly Gln Pro Val Ser Leu Lys Asn Ile Ser Thr Asp Thr Ser Gly Tyr 
        195                 200                 205             


Tyr Ile Cys Thr Ser Ser Asn Glu Glu Gly Thr Gln Phe Cys Asn Ile 
    210                 215                 220                 


Thr Val Ala Val Arg Ser Pro Ser Met Asn Val Ala Leu Tyr Val Gly 
225                 230                 235                 240 


Ile Ala Val Gly Val Val Ala Ala Leu Ile Ile Ile Gly Ile Ile Ile 
                245                 250                 255     


Tyr Cys Cys Cys Cys Arg Gly Lys Asp Asp Asn Thr Glu Asp Lys Glu 
            260                 265                 270         


Asp Ala Arg Pro Asn Arg Glu Ala Tyr Glu Glu Pro Pro Glu Gln Leu 
        275                 280                 285             


Arg Glu Leu Ser Arg Glu Arg Glu Glu Glu Asp Asp Tyr Arg Gln Glu 
    290                 295                 300                 


Glu Gln Arg Ser Thr Gly Arg Glu Ser Pro Asp His Leu Asp Gln 
305                 310                 315                 


<210>  4601
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAA1__Homo_sapiens__NP_003792

<400>  4601

Met Gly Leu Leu Ser Asp Pro Val Arg Arg Arg Ala Leu Ala Arg Leu 
1               5                   10                  15      


Val Leu Arg Leu Asn Ala Pro Leu Cys Val Leu Ser Tyr Val Ala Gly 
            20                  25                  30          


Ile Ala Trp Phe Leu Ala Leu Val Phe Pro Pro Leu Thr Gln Arg Thr 
        35                  40                  45              


Tyr Met Ser Glu Asn Ala Met Gly Ser Thr Met Val Glu Glu Gln Phe 
    50                  55                  60                  


Ala Gly Gly Asp Arg Ala Arg Ala Phe Ala Arg Asp Phe Ala Ala His 
65                  70                  75                  80  


Arg Lys Lys Ser Gly Ala Leu Pro Val Ala Trp Leu Glu Arg Thr Met 
                85                  90                  95      


Arg Ser Val Gly Leu Glu Val Tyr Thr Gln Ser Phe Ser Arg Lys Leu 
            100                 105                 110         


Pro Phe Pro Asp Glu Thr His Glu Arg Tyr Met Val Ser Gly Thr Asn 
        115                 120                 125             


Val Tyr Gly Ile Leu Arg Ala Pro Arg Ala Ala Ser Thr Glu Ser Leu 
    130                 135                 140                 


Val Leu Thr Val Pro Cys Gly Ser Asp Ser Thr Asn Ser Gln Ala Val 
145                 150                 155                 160 


Gly Leu Leu Leu Ala Leu Ala Ala His Phe Arg Gly Gln Ile Tyr Trp 
                165                 170                 175     


Ala Lys Asp Ile Val Phe Leu Val Thr Glu His Asp Leu Leu Gly Thr 
            180                 185                 190         


Glu Ala Trp Leu Glu Ala Tyr His Asp Val Asn Val Thr Gly Met Gln 
        195                 200                 205             


Ser Ser Pro Leu Gln Gly Arg Ala Gly Ala Ile Gln Ala Ala Val Ala 
    210                 215                 220                 


Leu Glu Leu Ser Ser Asp Val Val Thr Ser Leu Asp Val Ala Val Glu 
225                 230                 235                 240 


Gly Leu Asn Gly Gln Leu Pro Asn Leu Asp Leu Leu Asn Leu Phe Gln 
                245                 250                 255     


Thr Phe Cys Gln Lys Gly Gly Leu Leu Cys Thr Leu Gln Gly Lys Leu 
            260                 265                 270         


Gln Pro Glu Asp Trp Thr Ser Leu Asp Gly Pro Leu Gln Gly Leu Gln 
        275                 280                 285             


Thr Leu Leu Leu Met Val Leu Arg Gln Ala Ser Gly Arg Pro His Gly 
    290                 295                 300                 


Ser His Gly Leu Phe Leu Arg Tyr Arg Val Glu Ala Leu Thr Leu Arg 
305                 310                 315                 320 


Gly Ile Asn Ser Phe Arg Gln Tyr Lys Tyr Asp Leu Val Ala Val Gly 
                325                 330                 335     


Lys Ala Leu Glu Gly Met Phe Arg Lys Leu Asn His Leu Leu Glu Arg 
            340                 345                 350         


Leu His Gln Ser Phe Phe Leu Tyr Leu Leu Pro Gly Leu Ser Arg Phe 
        355                 360                 365             


Val Ser Ile Gly Leu Tyr Met Pro Ala Val Gly Phe Leu Leu Leu Val 
    370                 375                 380                 


Leu Gly Leu Lys Ala Leu Glu Leu Trp Met Gln Leu His Glu Ala Gly 
385                 390                 395                 400 


Met Gly Leu Glu Glu Pro Gly Gly Ala Pro Gly Pro Ser Val Pro Leu 
                405                 410                 415     


Pro Pro Ser Gln Gly Val Gly Leu Ala Ser Leu Val Ala Pro Leu Leu 
            420                 425                 430         


Ile Ser Gln Ala Met Gly Leu Ala Leu Tyr Val Leu Pro Val Leu Gly 
        435                 440                 445             


Gln His Val Ala Thr Gln His Phe Pro Val Ala Glu Ala Glu Ala Val 
    450                 455                 460                 


Val Leu Thr Leu Leu Ala Ile Tyr Ala Ala Gly Leu Ala Leu Pro His 
465                 470                 475                 480 


Asn Thr His Arg Val Val Ser Thr Gln Ala Pro Asp Arg Gly Trp Met 
                485                 490                 495     


Ala Leu Lys Leu Val Ala Leu Ile Tyr Leu Ala Leu Gln Leu Gly Cys 
            500                 505                 510         


Ile Ala Leu Thr Asn Phe Ser Leu Gly Phe Leu Leu Ala Thr Thr Met 
        515                 520                 525             


Val Pro Thr Ala Ala Leu Ala Lys Pro His Gly Pro Arg Thr Leu Tyr 
    530                 535                 540                 


Ala Ala Leu Leu Val Leu Thr Ser Pro Ala Ala Thr Leu Leu Gly Ser 
545                 550                 555                 560 


Leu Phe Leu Trp Arg Glu Leu Gln Glu Ala Pro Leu Ser Leu Ala Glu 
                565                 570                 575     


Gly Trp Gln Leu Phe Leu Ala Ala Leu Ala Gln Gly Val Leu Glu His 
            580                 585                 590         


His Thr Tyr Gly Ala Leu Leu Phe Pro Leu Leu Ser Leu Gly Leu Tyr 
        595                 600                 605             


Pro Cys Trp Leu Leu Phe Trp Asn Val Leu Phe Trp Lys 
    610                 615                 620     


<210>  4602
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPALPP1__Homo_sapiens__NP_061029

<400>  4602

Met Ala Arg Asp Leu Ile Gly Pro Ala Leu Pro Pro Gly Phe Lys Ala 
1               5                   10                  15      


Arg Gly Thr Ala Glu Asp Glu Glu Arg Asp Pro Ser Pro Val Ala Gly 
            20                  25                  30          


Pro Ala Leu Pro Pro Asn Tyr Lys Ser Ser Ser Ser Asp Ser Ser Asp 
        35                  40                  45              


Ser Asp Glu Asp Ser Ser Ser Leu Tyr Glu Glu Gly Asn Gln Glu Ser 
    50                  55                  60                  


Glu Glu Asp Asp Ser Gly Pro Thr Ala Arg Lys Gln Arg Lys Asn Gln 
65                  70                  75                  80  


Asp Asp Asp Asp Asp Asp Asp Asp Gly Phe Phe Gly Pro Ala Leu Pro 
                85                  90                  95      


Pro Gly Phe Lys Lys Gln Asp Asp Ser Pro Pro Arg Pro Ile Ile Gly 
            100                 105                 110         


Pro Ala Leu Pro Pro Gly Phe Ile Lys Ser Thr Gln Lys Ser Asp Lys 
        115                 120                 125             


Gly Arg Asp Asp Pro Gly Gln Gln Glu Thr Asp Ser Ser Glu Asp Glu 
    130                 135                 140                 


Asp Ile Ile Gly Pro Met Pro Ala Lys Gly Pro Val Asn Tyr Asn Val 
145                 150                 155                 160 


Thr Thr Glu Phe Glu Lys Arg Ala Gln Arg Met Lys Glu Lys Leu Thr 
                165                 170                 175     


Lys Gly Asp Asp Asp Ser Ser Lys Pro Ile Val Arg Glu Ser Trp Met 
            180                 185                 190         


Thr Glu Leu Pro Pro Glu Met Lys Asp Phe Gly Leu Gly Pro Arg Thr 
        195                 200                 205             


Phe Lys Arg Arg Ala Asp Asp Thr Ser Gly Asp Arg Ser Ile Trp Thr 
    210                 215                 220                 


Asp Thr Pro Ala Asp Arg Glu Arg Lys Ala Lys Glu Thr Gln Glu Ala 
225                 230                 235                 240 


Arg Lys Ser Ser Ser Lys Lys Asp Glu Glu His Ile Leu Ser Gly Arg 
                245                 250                 255     


Asp Lys Arg Leu Ala Glu Gln Val Ser Ser Tyr Asn Glu Ser Lys Arg 
            260                 265                 270         


Ser Glu Ser Leu Met Asp Ile His His Lys Lys Leu Lys Ser Lys Ala 
        275                 280                 285             


Ala Glu Asp Lys Asn Lys Pro Gln Glu Arg Ile Pro Phe Asp Arg Asp 
    290                 295                 300                 


Lys Asp Leu Lys Val Asn Arg Phe Asp Glu Ala Gln Lys Lys Ala Leu 
305                 310                 315                 320 


Ile Lys Lys Ser Arg Glu Leu Asn Thr Arg Phe Ser His Gly Lys Gly 
                325                 330                 335     


Asn Met Phe Leu 
            340 


<210>  4603
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAM__Homo_sapiens__XP_005270055

<400>  4603

Met Asp Glu Ser Ala Leu Thr Leu Gly Thr Ile Asp Val Ser Tyr Leu 
1               5                   10                  15      


Pro His Ser Ser Glu Tyr Ser Val Gly Arg Cys Lys His Thr Ser Glu 
            20                  25                  30          


Glu Trp Gly Glu Cys Gly Phe Arg Pro Thr Ile Phe Arg Ser Ala Thr 
        35                  40                  45              


Leu Lys Trp Lys Glu Ser Leu Met Ser Arg Lys Arg Pro Phe Val Gly 
    50                  55                  60                  


Arg Cys Cys Tyr Ser Cys Thr Pro Gln Ser Trp Asp Lys Phe Phe Asn 
65                  70                  75                  80  


Pro Ser Ile Pro Ser Leu Gly Leu Arg Asn Val Ile Tyr Ile Asn Glu 
                85                  90                  95      


Thr His Thr Arg His Arg Gly Trp Leu Ala Arg Arg Leu Ser Tyr Val 
            100                 105                 110         


Leu Phe Ile Gln Glu Arg Asp Val His Lys Gly Met Phe Ala Thr Asn 
        115                 120                 125             


Val Thr Glu Asn Val Leu Asn Ser Ser Arg Val Gln Glu Ala Ile Ala 
    130                 135                 140                 


Glu Val Ala Ala Glu Leu Asn Pro Asp Gly Ser Ala Gln Gln Gln Ser 
145                 150                 155                 160 


Lys Ala Val Asn Lys Val Lys Lys Lys Ala Lys Arg Ile Leu Gln Glu 
                165                 170                 175     


Met Val Ala Thr Val Ser Pro Ala Met Ile Arg Leu Thr Gly Trp Val 
            180                 185                 190         


Leu Leu Lys Leu Phe Asn Ser Phe Phe Trp Asn Ile Gln Ile His Lys 
        195                 200                 205             


Gly Gln Leu Glu Met Val Lys Ala Ala Thr Glu Thr Asn Leu Pro Leu 
    210                 215                 220                 


Leu Phe Leu Pro Val His Arg Ser His Ile Asp Tyr Leu Leu Leu Thr 
225                 230                 235                 240 


Phe Ile Leu Phe Cys His Asn Ile Lys Ala Pro Tyr Ile Ala Ser Gly 
                245                 250                 255     


Asn Asn Leu Asn Ile Pro Ile Phe Ser Thr Leu Ile His Lys Leu Gly 
            260                 265                 270         


Gly Phe Phe Ile Arg Arg Arg Leu Asp Glu Thr Pro Asp Gly Arg Lys 
        275                 280                 285             


Asp Val Leu Tyr Arg Ala Leu Leu His Gly His Ile Val Glu Leu Leu 
    290                 295                 300                 


Arg Gln Gln Gln Phe Leu Glu Ile Phe Leu Glu Gly Thr Arg Ser Arg 
305                 310                 315                 320 


Ser Gly Lys Thr Ser Cys Ala Arg Ala Gly Leu Leu Ser Val Val Val 
                325                 330                 335     


Asp Thr Leu Ser Thr Asn Val Ile Pro Asp Ile Leu Ile Ile Pro Val 
            340                 345                 350         


Gly Ile Ser Tyr Asp Arg Ile Ile Glu Gly His Tyr Asn Gly Glu Gln 
        355                 360                 365             


Leu Gly Lys Pro Lys Lys Asn Glu Ser Leu Trp Ser Val Ala Arg Gly 
    370                 375                 380                 


Val Ile Arg Met Leu Arg Lys Asn Tyr Gly Cys Val Arg Val Asp Phe 
385                 390                 395                 400 


Ala Gln Pro Phe Ser Leu Lys Glu Tyr Leu Glu Ser Gln Ser Gln Lys 
                405                 410                 415     


Pro Val Ser Ala Leu Leu Ser Leu Glu Gln Ala Leu Leu Pro Ala Ile 
            420                 425                 430         


Leu Pro Ser Arg Pro Ser Asp Ala Ala Asp Glu Gly Arg Asp Thr Ser 
        435                 440                 445             


Ile Asn Glu Ser Arg Asn Ala Thr Asp Glu Ser Leu Arg Arg Arg Leu 
    450                 455                 460                 


Ile Ala Asn Leu Ala Glu His Ile Leu Phe Thr Ala Ser Lys Ser Cys 
465                 470                 475                 480 


Ala Ile Met Ser Thr His Ile Val Ala Cys Leu Leu Leu Tyr Arg His 
                485                 490                 495     


Arg Gln Gly Ile Asp Leu Ser Thr Leu Val Glu Asp Phe Phe Val Met 
            500                 505                 510         


Lys Glu Glu Val Leu Ala Arg Asp Phe Asp Leu Gly Phe Ser Gly Asn 
        515                 520                 525             


Ser Glu Asp Val Val Met His Ala Ile Gln Leu Leu Gly Asn Cys Val 
    530                 535                 540                 


Thr Ile Thr His Thr Ser Arg Asn Asp Glu Phe Phe Ile Thr Pro Ser 
545                 550                 555                 560 


Thr Thr Val Pro Ser Val Phe Glu Leu Asn Phe Tyr Ser Asn Gly Val 
                565                 570                 575     


Leu His Val Phe Ile Met Glu Ala Ile Ile Ala Cys Ser Leu Tyr Ala 
            580                 585                 590         


Val Leu Asn Lys Arg Gly Leu Gly Gly Pro Thr Ser Thr Pro Pro Asn 
        595                 600                 605             


Leu Ile Ser Gln Glu Gln Leu Val Arg Lys Ala Ala Ser Leu Cys Tyr 
    610                 615                 620                 


Leu Leu Ser Asn Glu Gly Thr Ile Ser Leu Pro Cys Gln Thr Phe Tyr 
625                 630                 635                 640 


Gln Val Cys His Glu Thr Val Gly Lys Phe Ile Gln Tyr Gly Ile Leu 
                645                 650                 655     


Thr Val Ala Glu His Asp Asp Gln Glu Asp Ile Ser Pro Ser Leu Ala 
            660                 665                 670         


Glu Gln Gln Trp Asp Lys Lys Leu Pro Glu Pro Leu Ser Trp Arg Ser 
        675                 680                 685             


Asp Glu Glu Asp Glu Asp Ser Asp Phe Gly Glu Glu Gln Arg Asp Cys 
    690                 695                 700                 


Tyr Leu Lys Val Ser Gln Ser Lys Glu His Gln Gln Phe Ile Thr Phe 
705                 710                 715                 720 


Leu Gln Arg Leu Leu Gly Pro Leu Leu Glu Ala Tyr Ser Ser Ala Ala 
                725                 730                 735     


Ile Phe Val His Asn Phe Ser Gly Pro Val Pro Glu Pro Glu Tyr Leu 
            740                 745                 750         


Gln Lys Leu His Lys Tyr Leu Ile Thr Arg Thr Glu Arg Asn Val Ala 
        755                 760                 765             


Val Tyr Ala Glu Ser Ala Thr Tyr Cys Leu Val Lys Asn Ala Val Lys 
    770                 775                 780                 


Met Phe Lys Asp Ile Gly Val Phe Lys Glu Thr Lys Gln Lys Arg Val 
785                 790                 795                 800 


Ser Val Leu Glu Leu Ser Ser Thr Phe Leu Pro Gln Cys Asn Arg Gln 
                805                 810                 815     


Lys Leu Leu Glu Tyr Ile Leu Ser Phe Val Val Leu 
            820                 825             


<210>  4604
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPANK1__Homo_sapiens__NP_149417

<400>  4604

Met Ser Arg Pro Leu Leu Ile Thr Phe Thr Pro Ala Thr Asp Pro Ser 
1               5                   10                  15      


Asp Leu Trp Lys Asp Gly Gln Gln Gln Pro Gln Pro Glu Lys Pro Glu 
            20                  25                  30          


Ser Thr Leu Asp Gly Ala Ala Ala Arg Ala Phe Tyr Glu Ala Leu Ile 
        35                  40                  45              


Gly Asp Glu Ser Ser Ala Pro Asp Ser Gln Arg Ser Gln Thr Glu Pro 
    50                  55                  60                  


Ala Arg Glu Arg Lys Arg Lys Lys Arg Arg Ile Met Lys Ala Pro Ala 
65                  70                  75                  80  


Ala Glu Ala Val Ala Glu Gly Ala Ser Gly Arg His Gly Gln Gly Arg 
                85                  90                  95      


Ser Leu Glu Ala Glu Asp Lys Met Thr His Arg Ile Leu Arg Ala Ala 
            100                 105                 110         


Gln Glu Gly Asp Leu Pro Glu Leu Arg Arg Leu Leu Glu Pro His Glu 
        115                 120                 125             


Ala Gly Gly Ala Gly Gly Asn Ile Asn Ala Arg Asp Ala Phe Trp Trp 
    130                 135                 140                 


Thr Pro Leu Met Cys Ala Ala Arg Ala Gly Gln Gly Ala Ala Val Ser 
145                 150                 155                 160 


Tyr Leu Leu Gly Arg Gly Ala Ala Trp Val Gly Val Cys Glu Leu Ser 
                165                 170                 175     


Gly Arg Asp Ala Ala Gln Leu Ala Glu Glu Ala Gly Phe Pro Glu Val 
            180                 185                 190         


Ala Arg Met Val Arg Glu Ser His Gly Glu Thr Arg Ser Pro Glu Asn 
        195                 200                 205             


Arg Ser Pro Thr Pro Ser Leu Gln Tyr Cys Glu Asn Cys Asp Thr His 
    210                 215                 220                 


Phe Gln Asp Ser Asn His Arg Thr Ser Thr Ala His Leu Leu Ser Leu 
225                 230                 235                 240 


Ser Gln Gly Pro Gln Pro Pro Asn Leu Pro Leu Gly Val Pro Ile Ser 
                245                 250                 255     


Ser Pro Gly Phe Lys Leu Leu Leu Arg Gly Gly Trp Glu Pro Gly Met 
            260                 265                 270         


Gly Leu Gly Pro Arg Gly Glu Gly Arg Ala Asn Pro Ile Pro Thr Val 
        275                 280                 285             


Leu Lys Arg Asp Gln Glu Gly Leu Gly Tyr Arg Ser Ala Pro Gln Pro 
    290                 295                 300                 


Arg Val Thr His Phe Pro Ala Trp Asp Thr Arg Ala Val Ala Gly Arg 
305                 310                 315                 320 


Glu Arg Pro Pro Arg Val Ala Thr Leu Ser Trp Arg Glu Glu Arg Arg 
                325                 330                 335     


Arg Glu Glu Lys Asp Arg Ala Trp Glu Arg Asp Leu Arg Thr Tyr Met 
            340                 345                 350         


Asn Leu Glu Phe 
        355     


<210>  4605
<211>  795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPAT2__Homo_sapiens__NP_997211

<400>  4605

Met Ala Thr Met Leu Glu Gly Arg Cys Gln Thr Gln Pro Arg Ser Ser 
1               5                   10                  15      


Pro Ser Gly Arg Glu Ala Ser Leu Trp Ser Ser Gly Phe Gly Met Lys 
            20                  25                  30          


Leu Glu Ala Val Thr Pro Phe Leu Gly Lys Tyr Arg Pro Phe Val Gly 
        35                  40                  45              


Arg Cys Cys Gln Thr Cys Thr Pro Lys Ser Trp Glu Ser Leu Phe His 
    50                  55                  60                  


Arg Ser Ile Thr Asp Leu Gly Phe Cys Asn Val Ile Leu Val Lys Glu 
65                  70                  75                  80  


Glu Asn Thr Arg Phe Arg Gly Trp Leu Val Arg Arg Leu Cys Tyr Phe 
                85                  90                  95      


Leu Trp Ser Leu Glu Gln His Ile Pro Pro Cys Gln Asp Val Pro Gln 
            100                 105                 110         


Lys Ile Met Glu Ser Thr Gly Val Gln Asn Leu Leu Ser Gly Arg Val 
        115                 120                 125             


Pro Gly Gly Thr Gly Glu Gly Gln Val Pro Asp Leu Val Lys Lys Glu 
    130                 135                 140                 


Val Gln Arg Ile Leu Gly His Ile Gln Ala Pro Pro Arg Pro Phe Leu 
145                 150                 155                 160 


Val Arg Leu Phe Ser Trp Ala Leu Leu Arg Phe Leu Asn Cys Leu Phe 
                165                 170                 175     


Leu Asn Val Gln Leu His Lys Gly Gln Met Lys Met Val Gln Lys Ala 
            180                 185                 190         


Ala Gln Ala Gly Leu Pro Leu Val Leu Leu Ser Thr His Lys Thr Leu 
        195                 200                 205             


Leu Asp Gly Ile Leu Leu Pro Phe Met Leu Leu Ser Gln Gly Leu Gly 
    210                 215                 220                 


Val Leu Arg Val Ala Trp Asp Ser Arg Ala Cys Ser Pro Ala Leu Arg 
225                 230                 235                 240 


Ala Leu Leu Arg Lys Leu Gly Gly Leu Phe Leu Pro Pro Glu Ala Ser 
                245                 250                 255     


Leu Ser Leu Asp Ser Ser Glu Gly Leu Leu Ala Arg Ala Val Val Gln 
            260                 265                 270         


Ala Val Ile Glu Gln Leu Leu Val Ser Gly Gln Pro Leu Leu Ile Phe 
        275                 280                 285             


Leu Glu Glu Pro Pro Gly Ala Leu Gly Pro Arg Leu Ser Ala Leu Gly 
    290                 295                 300                 


Gln Ala Trp Val Gly Phe Val Val Gln Ala Val Gln Val Gly Ile Val 
305                 310                 315                 320 


Pro Asp Ala Leu Leu Val Pro Val Ala Val Thr Tyr Asp Leu Val Pro 
                325                 330                 335     


Asp Ala Pro Cys Asp Ile Asp His Ala Ser Ala Pro Leu Gly Leu Trp 
            340                 345                 350         


Thr Gly Ala Leu Ala Val Leu Arg Ser Leu Trp Ser Arg Trp Gly Cys 
        355                 360                 365             


Ser His Arg Ile Cys Ser Arg Val His Leu Ala Gln Pro Phe Ser Leu 
    370                 375                 380                 


Gln Glu Tyr Ile Val Ser Ala Arg Ser Cys Trp Gly Gly Arg Gln Thr 
385                 390                 395                 400 


Leu Glu Gln Leu Leu Gln Pro Ile Val Leu Gly Gln Cys Thr Ala Val 
                405                 410                 415     


Pro Asp Thr Glu Lys Glu Gln Glu Trp Thr Pro Ile Thr Gly Pro Leu 
            420                 425                 430         


Leu Ala Leu Lys Glu Glu Asp Gln Leu Leu Val Arg Arg Leu Ser Cys 
        435                 440                 445             


His Val Leu Ser Ala Ser Val Gly Ser Ser Ala Val Met Ser Thr Ala 
    450                 455                 460                 


Ile Met Ala Thr Leu Leu Leu Phe Lys His Gln Lys Leu Leu Gly Glu 
465                 470                 475                 480 


Phe Ser Trp Leu Thr Glu Glu Ile Leu Leu Arg Gly Phe Asp Val Gly 
                485                 490                 495     


Phe Ser Gly Gln Leu Arg Ser Leu Leu Gln His Ser Leu Ser Leu Leu 
            500                 505                 510         


Arg Ala His Val Ala Leu Leu Arg Ile Arg Gln Gly Asp Leu Leu Val 
        515                 520                 525             


Val Pro Gln Pro Gly Pro Gly Leu Thr His Leu Ala Gln Leu Ser Ala 
    530                 535                 540                 


Glu Leu Leu Pro Val Phe Leu Ser Glu Ala Val Gly Ala Cys Ala Val 
545                 550                 555                 560 


Arg Gly Leu Leu Ala Gly Arg Val Pro Pro Gln Gly Pro Trp Glu Leu 
                565                 570                 575     


Gln Gly Ile Leu Leu Leu Ser Gln Asn Glu Leu Tyr Arg Gln Ile Leu 
            580                 585                 590         


Leu Leu Met His Leu Leu Pro Gln Asp Leu Leu Leu Leu Lys Pro Cys 
        595                 600                 605             


Gln Ser Ser Tyr Cys Tyr Cys Gln Glu Val Leu Asp Arg Leu Ile Gln 
    610                 615                 620                 


Cys Gly Leu Leu Val Ala Glu Glu Thr Pro Gly Ser Arg Pro Ala Cys 
625                 630                 635                 640 


Asp Thr Gly Arg Gln Arg Leu Ser Arg Lys Leu Leu Trp Lys Pro Ser 
                645                 650                 655     


Gly Asp Phe Thr Asp Ser Asp Ser Asp Asp Phe Gly Glu Ala Asp Gly 
            660                 665                 670         


Arg Tyr Phe Arg Leu Ser Gln Gln Ser His Cys Pro Asp Phe Phe Leu 
        675                 680                 685             


Phe Leu Cys Arg Leu Leu Ser Pro Leu Leu Lys Ala Phe Ala Gln Ala 
    690                 695                 700                 


Ala Ala Phe Leu Arg Gln Gly Gln Leu Pro Asp Thr Glu Leu Gly Tyr 
705                 710                 715                 720 


Thr Glu Gln Leu Phe Gln Phe Leu Gln Ala Thr Ala Gln Glu Glu Gly 
                725                 730                 735     


Ile Phe Glu Cys Ala Asp Pro Lys Leu Ala Ile Ser Ala Val Trp Thr 
            740                 745                 750         


Phe Arg Asp Leu Gly Val Leu Gln Gln Thr Pro Ser Pro Ala Gly Pro 
        755                 760                 765             


Arg Leu His Leu Ser Pro Thr Phe Ala Ser Leu Asp Asn Gln Glu Lys 
    770                 775                 780                 


Leu Glu Gln Phe Ile Arg Gln Phe Ile Cys Ser 
785                 790                 795 


<210>  4606
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPATCH1__Homo_sapiens__NP_060495

<400>  4606

Met Ala Ala Arg Asp Ser Asp Ser Glu Glu Asp Leu Val Ser Tyr Gly 
1               5                   10                  15      


Thr Gly Leu Glu Pro Leu Glu Glu Gly Glu Arg Pro Lys Lys Pro Ile 
            20                  25                  30          


Pro Leu Gln Asp Gln Thr Val Arg Asp Glu Lys Gly Arg Tyr Lys Arg 
        35                  40                  45              


Phe His Gly Ala Phe Ser Gly Gly Phe Ser Ala Gly Tyr Phe Asn Thr 
    50                  55                  60                  


Val Gly Ser Lys Glu Gly Trp Thr Pro Ser Thr Phe Val Ser Ser Arg 
65                  70                  75                  80  


Gln Asn Arg Ala Asp Lys Ser Val Leu Gly Pro Glu Asp Phe Met Asp 
                85                  90                  95      


Glu Glu Asp Leu Ser Glu Phe Gly Ile Ala Pro Lys Ala Ile Val Thr 
            100                 105                 110         


Thr Asp Asp Phe Ala Ser Lys Thr Lys Asp Arg Ile Arg Glu Lys Ala 
        115                 120                 125             


Arg Gln Leu Ala Ala Ala Thr Ala Pro Ile Pro Gly Ala Thr Leu Leu 
    130                 135                 140                 


Asp Asp Leu Ile Thr Pro Ala Lys Leu Ser Val Gly Phe Glu Leu Leu 
145                 150                 155                 160 


Arg Lys Met Gly Trp Lys Glu Gly Gln Gly Val Gly Pro Arg Val Lys 
                165                 170                 175     


Arg Arg Pro Arg Arg Gln Lys Pro Asp Pro Gly Val Lys Ile Tyr Gly 
            180                 185                 190         


Cys Ala Leu Pro Pro Gly Ser Ser Glu Gly Ser Glu Gly Glu Asp Asp 
        195                 200                 205             


Asp Tyr Leu Pro Asp Asn Val Thr Phe Ala Pro Lys Asp Val Thr Pro 
    210                 215                 220                 


Val Asp Phe Thr Pro Lys Asp Asn Val His Gly Leu Ala Tyr Lys Gly 
225                 230                 235                 240 


Leu Asp Pro His Gln Ala Leu Phe Gly Thr Ser Gly Glu His Phe Asn 
                245                 250                 255     


Leu Phe Ser Gly Gly Ser Glu Arg Ala Gly Asp Leu Gly Glu Ile Gly 
            260                 265                 270         


Leu Asn Lys Gly Arg Lys Leu Gly Ile Ser Gly Gln Ala Phe Gly Val 
        275                 280                 285             


Gly Ala Leu Glu Glu Glu Asp Asp Asp Ile Tyr Ala Thr Glu Thr Leu 
    290                 295                 300                 


Ser Lys Tyr Asp Thr Val Leu Lys Asp Glu Glu Pro Gly Asp Gly Leu 
305                 310                 315                 320 


Tyr Gly Trp Thr Ala Pro Arg Gln Tyr Lys Asn Gln Lys Glu Ser Glu 
                325                 330                 335     


Lys Asp Leu Arg Tyr Val Gly Lys Ile Leu Asp Gly Phe Ser Leu Ala 
            340                 345                 350         


Ser Lys Pro Leu Ser Ser Lys Lys Ile Tyr Pro Pro Pro Glu Leu Pro 
        355                 360                 365             


Arg Asp Tyr Arg Pro Val His Tyr Phe Arg Pro Met Val Ala Ala Thr 
    370                 375                 380                 


Ser Glu Asn Ser His Leu Leu Gln Val Leu Ser Glu Ser Ala Gly Lys 
385                 390                 395                 400 


Ala Thr Pro Asp Pro Gly Thr His Ser Lys His Gln Leu Asn Ala Ser 
                405                 410                 415     


Lys Arg Ala Glu Leu Leu Gly Glu Thr Pro Ile Gln Gly Ser Ala Thr 
            420                 425                 430         


Ser Val Leu Glu Phe Leu Ser Gln Lys Asp Lys Glu Arg Ile Lys Glu 
        435                 440                 445             


Met Lys Gln Ala Thr Asp Leu Lys Ala Ala Gln Leu Lys Ala Arg Ser 
    450                 455                 460                 


Leu Ala Gln Asn Ala Gln Ser Ser Arg Ala Gln Leu Ser Pro Ala Ala 
465                 470                 475                 480 


Ala Ala Gly His Cys Ser Trp Asn Met Ala Leu Gly Gly Gly Thr Ala 
                485                 490                 495     


Thr Leu Lys Ala Ser Asn Phe Lys Pro Phe Ala Lys Asp Pro Glu Lys 
            500                 505                 510         


Gln Lys Arg Tyr Asp Glu Phe Leu Val His Met Lys Gln Gly Gln Lys 
        515                 520                 525             


Asp Ala Leu Glu Arg Cys Leu Asp Pro Ser Met Thr Glu Trp Glu Arg 
    530                 535                 540                 


Gly Arg Glu Arg Asp Glu Phe Ala Arg Ala Ala Leu Leu Tyr Ala Ser 
545                 550                 555                 560 


Ser His Ser Thr Leu Ser Ser Arg Phe Thr His Ala Lys Glu Glu Asp 
                565                 570                 575     


Asp Ser Asp Gln Val Glu Val Pro Arg Asp Gln Glu Asn Asp Val Gly 
            580                 585                 590         


Asp Lys Gln Ser Ala Val Lys Met Lys Met Phe Gly Lys Leu Thr Arg 
        595                 600                 605             


Asp Thr Phe Glu Trp His Pro Asp Lys Leu Leu Cys Lys Arg Phe Asn 
    610                 615                 620                 


Val Pro Asp Pro Tyr Pro Asp Ser Thr Leu Val Gly Leu Pro Arg Val 
625                 630                 635                 640 


Lys Arg Asp Lys Tyr Ser Val Phe Asn Phe Leu Thr Leu Pro Glu Thr 
                645                 650                 655     


Ala Ser Leu Pro Thr Thr Gln Ala Ser Ser Glu Lys Val Ser Gln His 
            660                 665                 670         


Arg Gly Pro Asp Lys Ser Arg Lys Pro Ser Arg Trp Asp Thr Ser Lys 
        675                 680                 685             


His Glu Lys Lys Glu Asp Ser Ile Ser Glu Phe Leu Ser Leu Ala Arg 
    690                 695                 700                 


Ser Lys Ala Glu Pro Pro Lys Gln Gln Ser Ser Pro Leu Val Asn Lys 
705                 710                 715                 720 


Glu Glu Glu His Ala Pro Glu Leu Ser Ala Asn Gln Thr Val Asn Lys 
                725                 730                 735     


Asp Val Asp Ala Gln Ala Glu Gly Glu Gly Ser Arg Pro Ser Met Asp 
            740                 745                 750         


Leu Phe Arg Ala Ile Phe Ala Ser Ser Ser Asp Glu Lys Ser Ser Ser 
        755                 760                 765             


Ser Glu Asp Glu Gln Gly Asp Ser Glu Asp Asp Gln Ala Gly Ser Gly 
    770                 775                 780                 


Glu Ala Asn Phe Gln Ser Ser Gln Asp Thr Asp Leu Gly Glu Thr Ser 
785                 790                 795                 800 


Ser Val Ala His Ala Leu Val Pro Ala Pro Gln Glu Pro Pro Pro Ser 
                805                 810                 815     


Phe Pro Ile Gln Lys Met Gln Ile Asp Glu Arg Glu Glu Phe Gly Pro 
            820                 825                 830         


Arg Leu Pro Pro Val Phe Cys Pro Asn Ala Arg Gln Thr Leu Glu Val 
        835                 840                 845             


Pro Gln Lys Glu Lys His Lys Lys Asn Lys Asp Lys His Lys Ala Lys 
    850                 855                 860                 


Lys Glu His Arg Arg Lys Lys Glu Lys Lys Lys Lys His Arg Lys His 
865                 870                 875                 880 


Lys His Lys Gly Lys Gln Lys Asn Lys Lys Pro Glu Lys Ser Ser Ser 
                885                 890                 895     


Ser Glu Ser Ser Asp Ser Ser Asp Ser Gln Ser Asp Glu Glu Thr Ala 
            900                 905                 910         


Asp Val Ser Pro Gln Glu Leu Leu Arg Arg Leu Lys Ser Leu Pro Leu 
        915                 920                 925             


Arg Arg Gln 
    930     


<210>  4607
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPATCH2__Homo_sapiens__NP_001284683

<400>  4607

Met Phe Gly Ala Ala Gly Arg Gln Pro Ile Gly Ala Pro Ala Ala Gly 
1               5                   10                  15      


Asn Ser Trp His Phe Ser Arg Thr Met Glu Glu Leu Val His Asp Leu 
            20                  25                  30          


Val Ser Ala Leu Glu Glu Ser Ser Glu Gln Ala Arg Gly Gly Phe Ala 
        35                  40                  45              


Glu Thr Gly Asp His Ser Arg Ser Ile Ser Cys Pro Leu Lys Arg Gln 
    50                  55                  60                  


Ala Arg Lys Arg Arg Gly Arg Lys Arg Arg Ser Tyr Asn Val His His 
65                  70                  75                  80  


Pro Trp Glu Thr Gly His Cys Leu Ser Glu Gly Ser Asp Ser Ser Leu 
                85                  90                  95      


Glu Glu Pro Ser Lys Asp Tyr Arg Glu Asn His Asn Asn Asn Lys Lys 
            100                 105                 110         


Asp His Ser Asp Ser Asp Asp Gln Met Leu Val Ala Lys Arg Arg Pro 
        115                 120                 125             


Ser Ser Asn Leu Asn Asn Asn Val Arg Gly Lys Arg Pro Leu Trp His 
    130                 135                 140                 


Glu Ser Asp Phe Ala Val Asp Asn Val Gly Asn Arg Thr Leu Arg Arg 
145                 150                 155                 160 


Arg Arg Lys Val Lys Arg Met Ala Val Asp Leu Pro Gln Asp Ile Ser 
                165                 170                 175     


Asn Lys Arg Thr Met Thr Gln Pro Pro Glu Gly Cys Arg Asp Gln Asp 
            180                 185                 190         


Met Asp Ser Asp Arg Ala Tyr Gln Tyr Gln Glu Phe Thr Lys Asn Lys 
        195                 200                 205             


Val Lys Lys Arg Lys Leu Lys Ile Ile Arg Gln Gly Pro Lys Ile Gln 
    210                 215                 220                 


Asp Glu Gly Val Val Leu Glu Ser Glu Glu Thr Asn Gln Thr Asn Lys 
225                 230                 235                 240 


Asp Lys Met Glu Cys Glu Glu Gln Lys Val Ser Asp Glu Leu Met Ser 
                245                 250                 255     


Glu Ser Asp Ser Ser Ser Leu Ser Ser Thr Asp Ala Gly Leu Phe Thr 
            260                 265                 270         


Asn Asp Glu Gly Arg Gln Gly Asp Asp Glu Gln Ser Asp Trp Phe Tyr 
        275                 280                 285             


Glu Lys Glu Ser Gly Gly Ala Cys Gly Ile Thr Gly Val Val Pro Trp 
    290                 295                 300                 


Trp Glu Lys Glu Asp Pro Thr Glu Leu Asp Lys Asn Val Pro Asp Pro 
305                 310                 315                 320 


Val Phe Glu Ser Ile Leu Thr Gly Ser Phe Pro Leu Met Ser His Pro 
                325                 330                 335     


Ser Arg Arg Gly Phe Gln Ala Arg Leu Ser Arg Leu His Gly Met Ser 
            340                 345                 350         


Ser Lys Asn Ile Lys Lys Ser Gly Gly Thr Pro Thr Ser Met Ala Thr 
        355                 360                 365             


Asn Trp Thr Ser Glu Ile Pro Leu 
    370                 375     


<210>  4608
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPATCH2L__Homo_sapiens__NP_060396

<400>  4608

Met Asp Glu Leu Val His Asp Leu Ala Ser Ala Leu Glu Gln Thr Ser 
1               5                   10                  15      


Glu Gln Asn Lys Leu Gly Glu Leu Trp Glu Glu Met Ala Leu Ser Pro 
            20                  25                  30          


Arg Gln Gln Arg Arg Gln Leu Arg Lys Arg Arg Gly Arg Lys Arg Arg 
        35                  40                  45              


Ser Asp Phe Thr His Leu Ala Glu His Thr Cys Cys Tyr Ser Glu Ala 
    50                  55                  60                  


Ser Glu Ser Ser Leu Asp Glu Ala Thr Lys Asp Cys Arg Glu Val Ala 
65                  70                  75                  80  


Pro Val Thr Asn Phe Ser Asp Ser Asp Asp Thr Met Val Ala Lys Arg 
                85                  90                  95      


His Pro Ala Leu Asn Ala Ile Val Lys Ser Lys Gln His Ser Trp His 
            100                 105                 110         


Glu Ser Asp Ser Phe Thr Glu Asn Ala Pro Cys Arg Pro Leu Arg Arg 
        115                 120                 125             


Arg Arg Lys Val Lys Arg Val Thr Ser Glu Val Ala Ala Ser Leu Gln 
    130                 135                 140                 


Gln Lys Leu Lys Val Ser Asp Trp Ser Tyr Glu Arg Gly Cys Arg Phe 
145                 150                 155                 160 


Lys Ser Ala Lys Lys Gln Arg Leu Ser Arg Trp Lys Glu Asn Thr Pro 
                165                 170                 175     


Trp Thr Ser Ser Gly His Gly Leu Cys Glu Ser Ala Glu Asn Arg Thr 
            180                 185                 190         


Phe Leu Ser Lys Thr Gly Arg Lys Glu Arg Met Glu Cys Glu Thr Asp 
        195                 200                 205             


Glu Gln Lys Gln Gly Ser Asp Glu Asn Met Ser Glu Cys Glu Thr Ser 
    210                 215                 220                 


Ser Val Cys Ser Ser Ser Asp Thr Gly Leu Phe Thr Asn Asp Glu Gly 
225                 230                 235                 240 


Arg Gln Gly Asp Asp Glu Gln Ser Asp Trp Phe Tyr Glu Gly Glu Cys 
                245                 250                 255     


Val Pro Gly Phe Thr Val Pro Asn Leu Leu Pro Lys Trp Ala Pro Asp 
            260                 265                 270         


His Cys Ser Glu Val Glu Arg Met Asp Ser Gly Leu Asp Lys Phe Ser 
        275                 280                 285             


Asp Ser Thr Phe Leu Leu Pro Ser Arg Pro Ala Gln Arg Gly Tyr His 
    290                 295                 300                 


Thr Arg Leu Asn Arg Leu Pro Gly Ala Ala Ala Arg Cys Leu Arg Lys 
305                 310                 315                 320 


Gly Arg Arg Arg Leu Val Gly Lys Glu Thr Ser Ile Asn Thr Leu Gly 
                325                 330                 335     


Thr Glu Arg Ile Ser His Ile Ile Ser Asp Pro Arg Gln Lys Glu Lys 
            340                 345                 350         


Asn Lys Ala Leu Ala Ser Asp Phe Pro His Ile Ser Ala Cys Ala His 
        355                 360                 365             


Glu Phe Asn Pro Leu Ser Pro Leu Tyr Ser Leu Asp Val Leu Ala Asp 
    370                 375                 380                 


Ala Ser His Arg Arg Cys Ser Pro Ala His Cys Ser Ala Arg Gln Ala 
385                 390                 395                 400 


Asn Val His Trp Gly Pro Pro Cys Ser Arg Asp Ile Lys Arg Lys Arg 
                405                 410                 415     


Lys Pro Val Ala Thr Ala Ser Leu Ser Ser Pro Ser Ala Val His Met 
            420                 425                 430         


Asp Ala Val Glu Pro Thr Thr Pro Ala Ser Gln Ala Pro Lys Ser Pro 
        435                 440                 445             


Ser Ser Glu Trp Leu Val Arg Thr Ser Ala Ala Glu Lys Ala Thr Asp 
    450                 455                 460                 


Ala Thr Thr Ala Thr Phe Phe Lys Met Pro Gln Glu Lys Ser Pro Gly 
465                 470                 475                 480 


Tyr Ser 
        


<210>  4609
<211>  1502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPATCH8__Homo_sapiens__NP_001002909

<400>  4609

Met Ala Asp Arg Phe Ser Arg Phe Asn Glu Asp Arg Asp Phe Gln Gly 
1               5                   10                  15      


Asn His Phe Asp Gln Tyr Glu Glu Gly His Leu Glu Ile Glu Gln Ala 
            20                  25                  30          


Ser Leu Asp Lys Pro Ile Glu Ser Asp Asn Ile Gly His Arg Leu Leu 
        35                  40                  45              


Gln Lys His Gly Trp Lys Leu Gly Gln Gly Leu Gly Lys Ser Leu Gln 
    50                  55                  60                  


Gly Arg Thr Asp Pro Ile Pro Ile Val Val Lys Tyr Asp Val Met Gly 
65                  70                  75                  80  


Met Gly Arg Met Glu Met Glu Leu Asp Tyr Ala Glu Asp Ala Thr Glu 
                85                  90                  95      


Arg Arg Arg Val Leu Glu Val Glu Lys Glu Asp Thr Glu Glu Leu Arg 
            100                 105                 110         


Gln Lys Tyr Lys Asp Tyr Val Asp Lys Glu Lys Ala Ile Ala Lys Ala 
        115                 120                 125             


Leu Glu Asp Leu Arg Ala Asn Phe Tyr Cys Glu Leu Cys Asp Lys Gln 
    130                 135                 140                 


Tyr Gln Lys His Gln Glu Phe Asp Asn His Ile Asn Ser Tyr Asp His 
145                 150                 155                 160 


Ala His Lys Gln Arg Leu Lys Asp Leu Lys Gln Arg Glu Phe Ala Arg 
                165                 170                 175     


Asn Val Ser Ser Arg Ser Arg Lys Asp Glu Lys Lys Gln Glu Lys Ala 
            180                 185                 190         


Leu Arg Arg Leu His Glu Leu Ala Glu Gln Arg Lys Gln Ala Glu Cys 
        195                 200                 205             


Ala Pro Gly Ser Gly Pro Met Phe Lys Pro Thr Thr Val Ala Val Asp 
    210                 215                 220                 


Glu Glu Gly Gly Glu Asp Asp Lys Asp Glu Ser Ala Thr Asn Ser Gly 
225                 230                 235                 240 


Thr Gly Ala Thr Ala Ser Cys Gly Leu Gly Ser Glu Phe Ser Thr Asp 
                245                 250                 255     


Lys Gly Gly Pro Phe Thr Ala Val Gln Ile Thr Asn Thr Thr Gly Leu 
            260                 265                 270         


Ala Gln Ala Pro Gly Leu Ala Ser Gln Gly Ile Ser Phe Gly Ile Lys 
        275                 280                 285             


Asn Asn Leu Gly Thr Pro Leu Gln Lys Leu Gly Val Ser Phe Ser Phe 
    290                 295                 300                 


Ala Lys Lys Ala Pro Val Lys Leu Glu Ser Ile Ala Ser Val Phe Lys 
305                 310                 315                 320 


Asp His Ala Glu Glu Gly Thr Ser Glu Asp Gly Thr Lys Pro Asp Glu 
                325                 330                 335     


Lys Ser Ser Asp Gln Gly Leu Gln Lys Val Gly Asp Ser Asp Gly Ser 
            340                 345                 350         


Ser Asn Leu Asp Gly Lys Lys Glu Asp Glu Asp Pro Gln Asp Gly Gly 
        355                 360                 365             


Ser Leu Ala Ser Thr Leu Ser Lys Leu Lys Arg Met Lys Arg Glu Glu 
    370                 375                 380                 


Gly Ala Gly Ala Thr Glu Pro Glu Tyr Tyr His Tyr Ile Pro Pro Ala 
385                 390                 395                 400 


His Cys Lys Val Lys Pro Asn Phe Pro Phe Leu Leu Phe Met Arg Ala 
                405                 410                 415     


Ser Glu Gln Met Asp Gly Asp Asn Thr Thr His Pro Lys Asn Ala Pro 
            420                 425                 430         


Glu Ser Lys Lys Gly Ser Ser Pro Lys Pro Lys Ser Cys Ile Lys Ala 
        435                 440                 445             


Ala Ala Ser Gln Gly Ala Glu Lys Thr Val Ser Glu Val Ser Glu Gln 
    450                 455                 460                 


Pro Lys Glu Thr Ser Met Thr Glu Pro Ser Glu Pro Gly Ser Lys Ala 
465                 470                 475                 480 


Glu Ala Lys Lys Ala Leu Gly Gly Asp Val Ser Asp Gln Ser Leu Glu 
                485                 490                 495     


Ser His Ser Gln Lys Val Ser Glu Thr Gln Met Cys Glu Ser Asn Ser 
            500                 505                 510         


Ser Lys Glu Thr Ser Leu Ala Thr Pro Ala Gly Lys Glu Ser Gln Glu 
        515                 520                 525             


Gly Pro Lys His Pro Thr Gly Pro Phe Phe Pro Val Leu Ser Lys Asp 
    530                 535                 540                 


Glu Ser Thr Ala Leu Gln Trp Pro Ser Glu Leu Leu Ile Phe Thr Lys 
545                 550                 555                 560 


Ala Glu Pro Ser Ile Ser Tyr Ser Cys Asn Pro Leu Tyr Phe Asp Phe 
                565                 570                 575     


Lys Leu Ser Arg Asn Lys Asp Ala Arg Thr Lys Gly Thr Glu Lys Pro 
            580                 585                 590         


Lys Asp Ile Gly Ser Ser Ser Lys Asp His Leu Gln Gly Leu Asp Pro 
        595                 600                 605             


Gly Glu Pro Asn Lys Ser Lys Glu Val Gly Gly Glu Lys Ile Val Arg 
    610                 615                 620                 


Ser Ser Gly Gly Arg Met Asp Ala Pro Ala Ser Gly Ser Ala Cys Ser 
625                 630                 635                 640 


Gly Leu Asn Lys Gln Glu Pro Gly Gly Ser His Gly Ser Glu Thr Glu 
                645                 650                 655     


Asp Thr Gly Arg Ser Leu Pro Ser Lys Lys Glu Arg Ser Gly Lys Ser 
            660                 665                 670         


His Arg His Lys Lys Lys Lys Lys His Lys Lys Ser Ser Lys His Lys 
        675                 680                 685             


Arg Lys His Lys Ala Asp Thr Glu Glu Lys Ser Ser Lys Ala Glu Ser 
    690                 695                 700                 


Gly Glu Lys Ser Lys Lys Arg Lys Lys Arg Lys Arg Lys Lys Asn Lys 
705                 710                 715                 720 


Ser Ser Ala Pro Ala Asp Ser Glu Arg Gly Pro Lys Pro Glu Pro Pro 
                725                 730                 735     


Gly Ser Gly Ser Pro Ala Pro Pro Arg Arg Arg Arg Arg Ala Gln Asp 
            740                 745                 750         


Asp Ser Gln Arg Arg Ser Leu Pro Ala Glu Glu Gly Ser Ser Gly Lys 
        755                 760                 765             


Lys Asp Glu Gly Gly Gly Gly Ser Ser Ser Gln Asp His Gly Gly Arg 
    770                 775                 780                 


Lys His Lys Gly Glu Leu Pro Pro Ser Ser Cys Gln Arg Arg Ala Gly 
785                 790                 795                 800 


Thr Lys Arg Ser Ser Arg Ser Ser His Arg Ser Gln Pro Ser Ser Gly 
                805                 810                 815     


Asp Glu Asp Ser Asp Asp Ala Ser Ser His Arg Leu His Gln Lys Ser 
            820                 825                 830         


Pro Ser Gln Tyr Ser Glu Glu Glu Glu Glu Glu Asp Ser Gly Ser Glu 
        835                 840                 845             


His Ser Arg Ser Arg Ser Arg Ser Gly Arg Arg His Ser Ser His Arg 
    850                 855                 860                 


Ser Ser Arg Arg Ser Tyr Ser Ser Ser Ser Asp Ala Ser Ser Asp Gln 
865                 870                 875                 880 


Ser Cys Tyr Ser Arg Gln Arg Ser Tyr Ser Asp Asp Ser Tyr Ser Asp 
                885                 890                 895     


Tyr Ser Asp Arg Ser Arg Arg His Ser Lys Arg Ser His Asp Ser Asp 
            900                 905                 910         


Asp Ser Asp Tyr Ala Ser Ser Lys His Arg Ser Lys Arg His Lys Tyr 
        915                 920                 925             


Ser Ser Ser Asp Asp Asp Tyr Ser Leu Ser Cys Ser Gln Ser Arg Ser 
    930                 935                 940                 


Arg Ser Arg Ser His Thr Arg Glu Arg Ser Arg Ser Arg Gly Arg Ser 
945                 950                 955                 960 


Arg Ser Ser Ser Cys Ser Arg Ser Arg Ser Lys Arg Arg Ser Arg Ser 
                965                 970                 975     


Thr Thr Ala His Ser Trp Gln Arg Ser Arg Ser Tyr Ser Arg Asp Arg 
            980                 985                 990         


Ser Arg Ser Thr Arg Ser Pro Ser  Gln Arg Ser Gly Ser  Arg Lys Arg 
        995                 1000                 1005             


Ser Trp  Gly His Glu Ser Pro  Glu Glu Arg His Ser  Gly Arg Arg 
    1010                 1015                 1020             


Asp Phe  Ile Arg Ser Lys Ile  Tyr Arg Ser Gln Ser  Pro His Tyr 
    1025                 1030                 1035             


Phe Arg  Ser Gly Arg Gly Glu  Gly Pro Gly Lys Lys  Asp Asp Gly 
    1040                 1045                 1050             


Arg Gly  Asp Asp Ser Lys Ala  Thr Gly Pro Pro Ser  Gln Asn Ser 
    1055                 1060                 1065             


Asn Ile  Gly Thr Gly Arg Gly  Ser Glu Gly Asp Cys  Ser Pro Glu 
    1070                 1075                 1080             


Asp Lys  Asn Ser Val Thr Ala  Lys Leu Leu Leu Glu  Lys Ile Gln 
    1085                 1090                 1095             


Ser Arg  Lys Val Glu Arg Lys  Pro Ser Val Ser Glu  Glu Val Gln 
    1100                 1105                 1110             


Ala Thr  Pro Asn Lys Ala Gly  Pro Lys Leu Lys Asp  Pro Pro Gln 
    1115                 1120                 1125             


Gly Tyr  Phe Gly Pro Lys Leu  Pro Pro Ser Leu Gly  Asn Lys Pro 
    1130                 1135                 1140             


Val Leu  Pro Leu Ile Gly Lys  Leu Pro Ala Thr Arg  Lys Pro Asn 
    1145                 1150                 1155             


Lys Lys  Cys Glu Glu Ser Gly  Leu Glu Arg Gly Glu  Glu Gln Glu 
    1160                 1165                 1170             


Gln Ser  Glu Thr Glu Glu Gly  Pro Pro Gly Ser Ser  Asp Ala Leu 
    1175                 1180                 1185             


Phe Gly  His Gln Phe Pro Ser  Glu Glu Thr Thr Gly  Pro Leu Leu 
    1190                 1195                 1200             


Asp Pro  Pro Pro Glu Glu Ser  Lys Ser Gly Glu Ala  Thr Ala Asp 
    1205                 1210                 1215             


His Pro  Val Ala Pro Leu Gly  Thr Pro Ala His Ser  Asp Cys Tyr 
    1220                 1225                 1230             


Pro Gly  Asp Pro Thr Ile Ser  His Asn Tyr Leu Pro  Asp Pro Ser 
    1235                 1240                 1245             


Asp Gly  Asp Thr Leu Glu Ser  Leu Asp Ser Ser Ser  Gln Pro Gly 
    1250                 1255                 1260             


Pro Val  Glu Ser Ser Leu Leu  Pro Ile Ala Pro Asp  Leu Glu His 
    1265                 1270                 1275             


Phe Pro  Ser Tyr Ala Pro Pro  Ser Gly Asp Pro Ser  Ile Glu Ser 
    1280                 1285                 1290             


Thr Asp  Gly Ala Glu Asp Ala  Ser Leu Ala Pro Leu  Glu Ser Gln 
    1295                 1300                 1305             


Pro Ile  Thr Phe Thr Pro Glu  Glu Met Glu Lys Tyr  Ser Lys Leu 
    1310                 1315                 1320             


Gln Gln  Ala Ala Gln Gln His  Ile Gln Gln Gln Leu  Leu Ala Lys 
    1325                 1330                 1335             


Gln Val  Lys Ala Phe Pro Ala  Ser Ala Ala Leu Ala  Pro Ala Thr 
    1340                 1345                 1350             


Pro Ala  Leu Gln Pro Ile His  Ile Gln Gln Pro Ala  Thr Ala Ser 
    1355                 1360                 1365             


Ala Thr  Ser Ile Thr Thr Val  Gln His Ala Ile Leu  Gln His His 
    1370                 1375                 1380             


Ala Ala  Ala Ala Ala Ala Ala  Ile Gly Ile His Pro  His Pro His 
    1385                 1390                 1395             


Pro Gln  Pro Leu Ala Gln Val  His His Ile Pro Gln  Pro His Leu 
    1400                 1405                 1410             


Thr Pro  Ile Ser Leu Ser His  Leu Thr His Ser Ile  Ile Pro Gly 
    1415                 1420                 1425             


His Pro  Ala Thr Phe Leu Ala  Ser His Pro Ile His  Ile Ile Pro 
    1430                 1435                 1440             


Ala Ser  Ala Ile His Pro Gly  Pro Phe Thr Phe His  Pro Val Pro 
    1445                 1450                 1455             


His Ala  Ala Leu Tyr Pro Thr  Leu Leu Ala Pro Arg  Pro Ala Ala 
    1460                 1465                 1470             


Ala Ala  Ala Thr Ala Leu His  Leu His Pro Leu Leu  His Pro Ile 
    1475                 1480                 1485             


Phe Ser  Gly Gln Asp Leu Gln  His Pro Pro Ser His  Gly Thr 
    1490                 1495                 1500         


<210>  4610
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPBAR1__Homo_sapiens__XP_011509046

<400>  4610

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  4611
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC1__Homo_sapiens__NP_002072

<400>  4611

Met Glu Leu Arg Ala Arg Gly Trp Trp Leu Leu Cys Ala Ala Ala Ala 
1               5                   10                  15      


Leu Val Ala Cys Ala Arg Gly Asp Pro Ala Ser Lys Ser Arg Ser Cys 
            20                  25                  30          


Gly Glu Val Arg Gln Ile Tyr Gly Ala Lys Gly Phe Ser Leu Ser Asp 
        35                  40                  45              


Val Pro Gln Ala Glu Ile Ser Gly Glu His Leu Arg Ile Cys Pro Gln 
    50                  55                  60                  


Gly Tyr Thr Cys Cys Thr Ser Glu Met Glu Glu Asn Leu Ala Asn Arg 
65                  70                  75                  80  


Ser His Ala Glu Leu Glu Thr Ala Leu Arg Asp Ser Ser Arg Val Leu 
                85                  90                  95      


Gln Ala Met Leu Ala Thr Gln Leu Arg Ser Phe Asp Asp His Phe Gln 
            100                 105                 110         


His Leu Leu Asn Asp Ser Glu Arg Thr Leu Gln Ala Thr Phe Pro Gly 
        115                 120                 125             


Ala Phe Gly Glu Leu Tyr Thr Gln Asn Ala Arg Ala Phe Arg Asp Leu 
    130                 135                 140                 


Tyr Ser Glu Leu Arg Leu Tyr Tyr Arg Gly Ala Asn Leu His Leu Glu 
145                 150                 155                 160 


Glu Thr Leu Ala Glu Phe Trp Ala Arg Leu Leu Glu Arg Leu Phe Lys 
                165                 170                 175     


Gln Leu His Pro Gln Leu Leu Leu Pro Asp Asp Tyr Leu Asp Cys Leu 
            180                 185                 190         


Gly Lys Gln Ala Glu Ala Leu Arg Pro Phe Gly Glu Ala Pro Arg Glu 
        195                 200                 205             


Leu Arg Leu Arg Ala Thr Arg Ala Phe Val Ala Ala Arg Ser Phe Val 
    210                 215                 220                 


Gln Gly Leu Gly Val Ala Ser Asp Val Val Arg Lys Val Ala Gln Val 
225                 230                 235                 240 


Pro Leu Gly Pro Glu Cys Ser Arg Ala Val Met Lys Leu Val Tyr Cys 
                245                 250                 255     


Ala His Cys Leu Gly Val Pro Gly Ala Arg Pro Cys Pro Asp Tyr Cys 
            260                 265                 270         


Arg Asn Val Leu Lys Gly Cys Leu Ala Asn Gln Ala Asp Leu Asp Ala 
        275                 280                 285             


Glu Trp Arg Asn Leu Leu Asp Ser Met Val Leu Ile Thr Asp Lys Phe 
    290                 295                 300                 


Trp Gly Thr Ser Gly Val Glu Ser Val Ile Gly Ser Val His Thr Trp 
305                 310                 315                 320 


Leu Ala Glu Ala Ile Asn Ala Leu Gln Asp Asn Arg Asp Thr Leu Thr 
                325                 330                 335     


Ala Lys Val Ile Gln Gly Cys Gly Asn Pro Lys Val Asn Pro Gln Gly 
            340                 345                 350         


Pro Gly Pro Glu Glu Lys Arg Arg Arg Gly Lys Leu Ala Pro Arg Glu 
        355                 360                 365             


Arg Pro Pro Ser Gly Thr Leu Glu Lys Leu Val Ser Glu Ala Lys Ala 
    370                 375                 380                 


Gln Leu Arg Asp Val Gln Asp Phe Trp Ile Ser Leu Pro Gly Thr Leu 
385                 390                 395                 400 


Cys Ser Glu Lys Met Ala Leu Ser Thr Ala Ser Asp Asp Arg Cys Trp 
                405                 410                 415     


Asn Gly Met Ala Arg Gly Arg Tyr Leu Pro Glu Val Met Gly Asp Gly 
            420                 425                 430         


Leu Ala Asn Gln Ile Asn Asn Pro Glu Val Glu Val Asp Ile Thr Lys 
        435                 440                 445             


Pro Asp Met Thr Ile Arg Gln Gln Ile Met Gln Leu Lys Ile Met Thr 
    450                 455                 460                 


Asn Arg Leu Arg Ser Ala Tyr Asn Gly Asn Asp Val Asp Phe Gln Asp 
465                 470                 475                 480 


Ala Ser Asp Asp Gly Ser Gly Ser Gly Ser Gly Asp Gly Cys Leu Asp 
                485                 490                 495     


Asp Leu Cys Ser Arg Lys Val Ser Arg Lys Ser Ser Ser Ser Arg Thr 
            500                 505                 510         


Pro Leu Thr His Ala Leu Pro Gly Leu Ser Glu Gln Glu Gly Gln Lys 
        515                 520                 525             


Thr Ser Ala Ala Ser Cys Pro Gln Pro Pro Thr Phe Leu Leu Pro Leu 
    530                 535                 540                 


Leu Leu Phe Leu Ala Leu Thr Val Ala Arg Pro Arg Trp Arg 
545                 550                 555             


<210>  4612
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC2__Homo_sapiens__NP_689955

<400>  4612

Met Ser Ala Leu Arg Pro Leu Leu Leu Leu Leu Leu Pro Leu Cys Pro 
1               5                   10                  15      


Gly Pro Gly Pro Gly Pro Gly Ser Glu Ala Lys Val Thr Arg Ser Cys 
            20                  25                  30          


Ala Glu Thr Arg Gln Val Leu Gly Ala Arg Gly Tyr Ser Leu Asn Leu 
        35                  40                  45              


Ile Pro Pro Ala Leu Ile Ser Gly Glu His Leu Arg Val Cys Pro Gln 
    50                  55                  60                  


Glu Tyr Thr Cys Cys Ser Ser Glu Thr Glu Gln Arg Leu Ile Arg Glu 
65                  70                  75                  80  


Thr Glu Ala Thr Phe Arg Gly Leu Val Glu Asp Ser Gly Ser Phe Leu 
                85                  90                  95      


Val His Thr Leu Ala Ala Arg His Arg Lys Phe Asp Glu Phe Phe Leu 
            100                 105                 110         


Glu Met Leu Ser Val Ala Gln His Ser Leu Thr Gln Leu Phe Ser His 
        115                 120                 125             


Ser Tyr Gly Arg Leu Tyr Ala Gln His Ala Leu Ile Phe Asn Gly Leu 
    130                 135                 140                 


Phe Ser Arg Leu Arg Asp Phe Tyr Gly Glu Ser Gly Glu Gly Leu Asp 
145                 150                 155                 160 


Asp Thr Leu Ala Asp Phe Trp Ala Gln Leu Leu Glu Arg Val Phe Pro 
                165                 170                 175     


Leu Leu His Pro Gln Tyr Ser Phe Pro Pro Asp Tyr Leu Leu Cys Leu 
            180                 185                 190         


Ser Arg Leu Ala Ser Ser Thr Asp Gly Ser Leu Gln Pro Phe Gly Asp 
        195                 200                 205             


Ser Pro Arg Arg Leu Arg Leu Gln Ile Thr Arg Thr Leu Val Ala Ala 
    210                 215                 220                 


Arg Ala Phe Val Gln Gly Leu Glu Thr Gly Arg Asn Val Val Ser Glu 
225                 230                 235                 240 


Ala Leu Lys Val Pro Val Ser Glu Gly Cys Ser Gln Ala Leu Met Arg 
                245                 250                 255     


Leu Ile Gly Cys Pro Leu Cys Arg Gly Val Pro Ser Leu Met Pro Cys 
            260                 265                 270         


Gln Gly Phe Cys Leu Asn Val Val Arg Gly Cys Leu Ser Ser Arg Gly 
        275                 280                 285             


Leu Glu Pro Asp Trp Gly Asn Tyr Leu Asp Gly Leu Leu Ile Leu Ala 
    290                 295                 300                 


Asp Lys Leu Gln Gly Pro Phe Ser Phe Glu Leu Thr Ala Glu Ser Ile 
305                 310                 315                 320 


Gly Val Lys Ile Ser Glu Gly Leu Met Tyr Leu Gln Glu Asn Ser Ala 
                325                 330                 335     


Lys Val Ser Ala Gln Val Phe Gln Glu Cys Gly Pro Pro Asp Pro Val 
            340                 345                 350         


Pro Ala Arg Asn Arg Arg Ala Pro Pro Pro Arg Glu Glu Ala Gly Arg 
        355                 360                 365             


Leu Trp Ser Met Val Thr Glu Glu Glu Arg Pro Thr Thr Ala Ala Gly 
    370                 375                 380                 


Thr Asn Leu His Arg Leu Val Trp Glu Leu Arg Glu Arg Leu Ala Arg 
385                 390                 395                 400 


Met Arg Gly Phe Trp Ala Arg Leu Ser Leu Thr Val Cys Gly Asp Ser 
                405                 410                 415     


Arg Met Ala Ala Asp Ala Ser Leu Glu Ala Ala Pro Cys Trp Thr Gly 
            420                 425                 430         


Ala Gly Arg Gly Arg Tyr Leu Pro Pro Val Val Gly Gly Ser Pro Ala 
        435                 440                 445             


Glu Gln Val Asn Asn Pro Glu Leu Lys Val Asp Ala Ser Gly Pro Asp 
    450                 455                 460                 


Val Pro Thr Arg Arg Arg Arg Leu Gln Leu Arg Ala Ala Thr Ala Arg 
465                 470                 475                 480 


Met Lys Thr Ala Ala Leu Gly His Asp Leu Asp Gly Gln Asp Ala Asp 
                485                 490                 495     


Glu Asp Ala Ser Gly Ser Gly Gly Gly Gln Gln Tyr Ala Asp Asp Trp 
            500                 505                 510         


Met Ala Gly Ala Val Ala Pro Pro Ala Arg Pro Pro Arg Pro Pro Tyr 
        515                 520                 525             


Pro Pro Arg Arg Asp Gly Ser Gly Gly Lys Gly Gly Gly Gly Ser Ala 
    530                 535                 540                 


Arg Tyr Asn Gln Gly Arg Ser Arg Ser Gly Gly Ala Ser Ile Gly Phe 
545                 550                 555                 560 


His Thr Gln Thr Ile Leu Ile Leu Ser Leu Ser Ala Leu Ala Leu Leu 
                565                 570                 575     


Gly Pro Arg 
            


<210>  4613
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3__Homo_sapiens__NP_001158089

<400>  4613

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Glu Thr Glu Lys Lys Ile Trp His 
            340                 345                 350         


Phe Lys Tyr Pro Ile Phe Phe Leu Cys Ile Gly Leu Asp Leu Gln Ile 
        355                 360                 365             


Gly Lys Leu Cys Ala His Ser Gln Gln Arg Gln Tyr Arg Ser Ala Tyr 
    370                 375                 380                 


Tyr Pro Glu Asp Leu Phe Ile Asp Lys Lys Val Leu Lys Val Ala His 
385                 390                 395                 400 


Val Glu His Glu Glu Thr Leu Ser Ser Arg Arg Arg Glu Leu Ile Gln 
                405                 410                 415     


Lys Leu Lys Ser Phe Ile Ser Phe Tyr Ser Ala Leu Pro Gly Tyr Ile 
            420                 425                 430         


Cys Ser His Ser Pro Val Ala Glu Asn Asp Thr Leu Cys Trp Asn Gly 
        435                 440                 445             


Gln Glu Leu Val Glu Arg Tyr Ser Gln Lys Ala Ala Arg Asn Gly Met 
    450                 455                 460                 


Lys Asn Gln Phe Asn Leu His Glu Leu Lys Met Lys Gly Pro Glu Pro 
465                 470                 475                 480 


Val Val Ser Gln Ile Ile Asp Lys Leu Lys His Ile Asn Gln Leu Leu 
                485                 490                 495     


Arg Thr Met Ser Met Pro Lys Gly Arg Val Leu Asp Lys Asn Leu Asp 
            500                 505                 510         


Glu Glu Gly Phe Glu Ser Gly Asp Cys Gly Asp Asp Glu Asp Glu Cys 
        515                 520                 525             


Ile Gly Gly Ser Gly Asp Gly Met Ile Lys Val Lys Asn Gln Leu Arg 
    530                 535                 540                 


Phe Leu Ala Glu Leu Ala Tyr Asp Leu Asp Val Asp Asp Ala Pro Gly 
545                 550                 555                 560 


Asn Ser Gln Gln Ala Thr Pro Lys Asp Asn Glu Ile Ser Thr Phe His 
                565                 570                 575     


Asn Leu Gly Asn Val His Ser Pro Leu Lys Leu Leu Thr Ser Met Ala 
            580                 585                 590         


Ile Ser Val Val Cys Phe Phe Phe Leu Val His 
        595                 600             


<210>  4614
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC4__Homo_sapiens__NP_001439

<400>  4614

Met Ala Arg Phe Gly Leu Pro Ala Leu Leu Cys Thr Leu Ala Val Leu 
1               5                   10                  15      


Ser Ala Ala Leu Leu Ala Ala Glu Leu Lys Ser Lys Ser Cys Ser Glu 
            20                  25                  30          


Val Arg Arg Leu Tyr Val Ser Lys Gly Phe Asn Lys Asn Asp Ala Pro 
        35                  40                  45              


Leu His Glu Ile Asn Gly Asp His Leu Lys Ile Cys Pro Gln Gly Ser 
    50                  55                  60                  


Thr Cys Cys Ser Gln Glu Met Glu Glu Lys Tyr Ser Leu Gln Ser Lys 
65                  70                  75                  80  


Asp Asp Phe Lys Ser Val Val Ser Glu Gln Cys Asn His Leu Gln Ala 
                85                  90                  95      


Val Phe Ala Ser Arg Tyr Lys Lys Phe Asp Glu Phe Phe Lys Glu Leu 
            100                 105                 110         


Leu Glu Asn Ala Glu Lys Ser Leu Asn Asp Met Phe Val Lys Thr Tyr 
        115                 120                 125             


Gly His Leu Tyr Met Gln Asn Ser Glu Leu Phe Lys Asp Leu Phe Val 
    130                 135                 140                 


Glu Leu Lys Arg Tyr Tyr Val Val Gly Asn Val Asn Leu Glu Glu Met 
145                 150                 155                 160 


Leu Asn Asp Phe Trp Ala Arg Leu Leu Glu Arg Met Phe Arg Leu Val 
                165                 170                 175     


Asn Ser Gln Tyr His Phe Thr Asp Glu Tyr Leu Glu Cys Val Ser Lys 
            180                 185                 190         


Tyr Thr Glu Gln Leu Lys Pro Phe Gly Asp Val Pro Arg Lys Leu Lys 
        195                 200                 205             


Leu Gln Val Thr Arg Ala Phe Val Ala Ala Arg Thr Phe Ala Gln Gly 
    210                 215                 220                 


Leu Ala Val Ala Gly Asp Val Val Ser Lys Val Ser Val Val Asn Pro 
225                 230                 235                 240 


Thr Ala Gln Cys Thr His Ala Leu Leu Lys Met Ile Tyr Cys Ser His 
                245                 250                 255     


Cys Arg Gly Leu Val Thr Val Lys Pro Cys Tyr Asn Tyr Cys Ser Asn 
            260                 265                 270         


Ile Met Arg Gly Cys Leu Ala Asn Gln Gly Asp Leu Asp Phe Glu Trp 
        275                 280                 285             


Asn Asn Phe Ile Asp Ala Met Leu Met Val Ala Glu Arg Leu Glu Gly 
    290                 295                 300                 


Pro Phe Asn Ile Glu Ser Val Met Asp Pro Ile Asp Val Lys Ile Ser 
305                 310                 315                 320 


Asp Ala Ile Met Asn Met Gln Asp Asn Ser Val Gln Val Ser Gln Lys 
                325                 330                 335     


Val Phe Gln Gly Cys Gly Pro Pro Lys Pro Leu Pro Ala Gly Arg Ile 
            340                 345                 350         


Ser Arg Ser Ile Ser Glu Ser Ala Phe Ser Ala Arg Phe Arg Pro His 
        355                 360                 365             


His Pro Glu Glu Arg Pro Thr Thr Ala Ala Gly Thr Ser Leu Asp Arg 
    370                 375                 380                 


Leu Val Thr Asp Val Lys Glu Lys Leu Lys Gln Ala Lys Lys Phe Trp 
385                 390                 395                 400 


Ser Ser Leu Pro Ser Asn Val Cys Asn Asp Glu Arg Met Ala Ala Gly 
                405                 410                 415     


Asn Gly Asn Glu Asp Asp Cys Trp Asn Gly Lys Gly Lys Ser Arg Tyr 
            420                 425                 430         


Leu Phe Ala Val Thr Gly Asn Gly Leu Ala Asn Gln Gly Asn Asn Pro 
        435                 440                 445             


Glu Val Gln Val Asp Thr Ser Lys Pro Asp Ile Leu Ile Leu Arg Gln 
    450                 455                 460                 


Ile Met Ala Leu Arg Val Met Thr Ser Lys Met Lys Asn Ala Tyr Asn 
465                 470                 475                 480 


Gly Asn Asp Val Asp Phe Phe Asp Ile Ser Asp Glu Ser Ser Gly Glu 
                485                 490                 495     


Gly Ser Gly Ser Gly Cys Glu Tyr Gln Gln Cys Pro Ser Glu Phe Asp 
            500                 505                 510         


Tyr Asn Ala Thr Asp His Ala Gly Lys Ser Ala Asn Glu Lys Ala Asp 
        515                 520                 525             


Ser Ala Gly Val Arg Pro Gly Ala Gln Ala Tyr Leu Leu Thr Val Phe 
    530                 535                 540                 


Cys Ile Leu Phe Leu Val Met Gln Arg Glu Trp Arg 
545                 550                 555     


<210>  4615
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC5__Homo_sapiens__NP_004457

<400>  4615

Met Asp Ala Gln Thr Trp Pro Val Gly Phe Arg Cys Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Val Gly Ser Ala Arg Ser Glu Gly Val Gln Thr Cys Glu Glu 
            20                  25                  30          


Val Arg Lys Leu Phe Gln Trp Arg Leu Leu Gly Ala Val Arg Gly Leu 
        35                  40                  45              


Pro Asp Ser Pro Arg Ala Gly Pro Asp Leu Gln Val Cys Ile Ser Lys 
    50                  55                  60                  


Lys Pro Thr Cys Cys Thr Arg Lys Met Glu Glu Arg Tyr Gln Ile Ala 
65                  70                  75                  80  


Ala Arg Gln Asp Met Gln Gln Phe Leu Gln Thr Ser Ser Ser Thr Leu 
                85                  90                  95      


Lys Phe Leu Ile Ser Arg Asn Ala Ala Ala Phe Gln Glu Thr Leu Glu 
            100                 105                 110         


Thr Leu Ile Lys Gln Ala Glu Asn Tyr Thr Ser Ile Leu Phe Cys Ser 
        115                 120                 125             


Thr Tyr Arg Asn Met Ala Leu Glu Ala Ala Ala Ser Val Gln Glu Phe 
    130                 135                 140                 


Phe Thr Asp Val Gly Leu Tyr Leu Phe Gly Ala Asp Val Asn Pro Glu 
145                 150                 155                 160 


Glu Phe Val Asn Arg Phe Phe Asp Ser Leu Phe Pro Leu Val Tyr Asn 
                165                 170                 175     


His Leu Ile Asn Pro Gly Val Thr Asp Ser Ser Leu Glu Tyr Ser Glu 
            180                 185                 190         


Cys Ile Arg Met Ala Arg Arg Asp Val Ser Pro Phe Gly Asn Ile Pro 
        195                 200                 205             


Gln Arg Val Met Gly Gln Met Gly Arg Ser Leu Leu Pro Ser Arg Thr 
    210                 215                 220                 


Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile Asn Thr Thr Asp 
225                 230                 235                 240 


Tyr Leu His Phe Ser Lys Glu Cys Ser Arg Ala Leu Leu Lys Met Gln 
                245                 250                 255     


Tyr Cys Pro His Cys Gln Gly Leu Ala Leu Thr Lys Pro Cys Met Gly 
            260                 265                 270         


Tyr Cys Leu Asn Val Met Arg Gly Cys Leu Ala His Met Ala Glu Leu 
        275                 280                 285             


Asn Pro His Trp His Ala Tyr Ile Arg Ser Leu Glu Glu Leu Ser Asp 
    290                 295                 300                 


Ala Met His Gly Thr Tyr Asp Ile Gly His Val Leu Leu Asn Phe His 
305                 310                 315                 320 


Leu Leu Val Asn Asp Ala Val Leu Gln Ala His Leu Asn Gly Gln Lys 
                325                 330                 335     


Leu Leu Glu Gln Val Asn Arg Ile Cys Gly Arg Pro Val Arg Thr Pro 
            340                 345                 350         


Thr Gln Ser Pro Arg Cys Ser Phe Asp Gln Ser Lys Glu Lys His Gly 
        355                 360                 365             


Met Lys Thr Thr Thr Arg Asn Ser Glu Glu Thr Leu Ala Asn Arg Arg 
    370                 375                 380                 


Lys Glu Phe Ile Asn Ser Leu Arg Leu Tyr Arg Ser Phe Tyr Gly Gly 
385                 390                 395                 400 


Leu Ala Asp Gln Leu Cys Ala Asn Glu Leu Ala Ala Ala Asp Gly Leu 
                405                 410                 415     


Pro Cys Trp Asn Gly Glu Asp Ile Val Lys Ser Tyr Thr Gln Arg Val 
            420                 425                 430         


Val Gly Asn Gly Ile Lys Ala Gln Ser Gly Asn Pro Glu Val Lys Val 
        435                 440                 445             


Lys Gly Ile Asp Pro Val Ile Asn Gln Ile Ile Asp Lys Leu Lys His 
    450                 455                 460                 


Val Val Gln Leu Leu Gln Gly Arg Ser Pro Lys Pro Asp Lys Trp Glu 
465                 470                 475                 480 


Leu Leu Gln Leu Gly Ser Gly Gly Gly Met Val Glu Gln Val Ser Gly 
                485                 490                 495     


Asp Cys Asp Asp Glu Asp Gly Cys Gly Gly Ser Gly Ser Gly Glu Val 
            500                 505                 510         


Lys Arg Thr Leu Lys Ile Thr Asp Trp Met Pro Asp Asp Met Asn Phe 
        515                 520                 525             


Ser Asp Val Lys Gln Ile His Gln Thr Asp Thr Gly Ser Thr Leu Asp 
    530                 535                 540                 


Thr Thr Gly Ala Gly Cys Ala Val Ala Thr Glu Ser Met Thr Phe Thr 
545                 550                 555                 560 


Leu Ile Ser Val Val Met Leu Leu Pro Gly Ile Trp 
                565                 570         


<210>  4616
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC6__Homo_sapiens__NP_005699

<400>  4616

Met Pro Ser Trp Ile Gly Ala Val Ile Leu Pro Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Ser Leu Pro Ala Gly Ala Asp Val Lys Ala Arg Ser Cys Gly Glu 
            20                  25                  30          


Val Arg Gln Ala Tyr Gly Ala Lys Gly Phe Ser Leu Ala Asp Ile Pro 
        35                  40                  45              


Tyr Gln Glu Ile Ala Gly Glu His Leu Arg Ile Cys Pro Gln Glu Tyr 
    50                  55                  60                  


Thr Cys Cys Thr Thr Glu Met Glu Asp Lys Leu Ser Gln Gln Ser Lys 
65                  70                  75                  80  


Leu Glu Phe Glu Asn Leu Val Glu Glu Thr Ser His Phe Val Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Arg His Lys Lys Phe Asp Glu Phe Phe Arg Glu Leu 
            100                 105                 110         


Leu Glu Asn Ala Glu Lys Ser Leu Asn Asp Met Phe Val Arg Thr Tyr 
        115                 120                 125             


Gly Met Leu Tyr Met Gln Asn Ser Glu Val Phe Gln Asp Leu Phe Thr 
    130                 135                 140                 


Glu Leu Lys Arg Tyr Tyr Thr Gly Gly Asn Val Asn Leu Glu Glu Met 
145                 150                 155                 160 


Leu Asn Asp Phe Trp Ala Arg Leu Leu Glu Arg Met Phe Gln Leu Ile 
                165                 170                 175     


Asn Pro Gln Tyr His Phe Ser Glu Asp Tyr Leu Glu Cys Val Ser Lys 
            180                 185                 190         


Tyr Thr Asp Gln Leu Lys Pro Phe Gly Asp Val Pro Arg Lys Leu Lys 
        195                 200                 205             


Ile Gln Val Thr Arg Ala Phe Ile Ala Ala Arg Thr Phe Val Gln Gly 
    210                 215                 220                 


Leu Thr Val Gly Arg Glu Val Ala Asn Arg Val Ser Lys Val Ser Pro 
225                 230                 235                 240 


Thr Pro Gly Cys Ile Arg Ala Leu Met Lys Met Leu Tyr Cys Pro Tyr 
                245                 250                 255     


Cys Arg Gly Leu Pro Thr Val Arg Pro Cys Asn Asn Tyr Cys Leu Asn 
            260                 265                 270         


Val Met Lys Gly Cys Leu Ala Asn Gln Ala Asp Leu Asp Thr Glu Trp 
        275                 280                 285             


Asn Leu Phe Ile Asp Ala Met Leu Leu Val Ala Glu Arg Leu Glu Gly 
    290                 295                 300                 


Pro Phe Asn Ile Glu Ser Val Met Asp Pro Ile Asp Val Lys Ile Ser 
305                 310                 315                 320 


Glu Ala Ile Met Asn Met Gln Glu Asn Ser Met Gln Val Ser Ala Lys 
                325                 330                 335     


Val Phe Gln Gly Cys Gly Gln Pro Lys Pro Ala Pro Ala Leu Arg Ser 
            340                 345                 350         


Ala Arg Ser Ala Pro Glu Asn Phe Asn Thr Arg Phe Arg Pro Tyr Asn 
        355                 360                 365             


Pro Glu Glu Arg Pro Thr Thr Ala Ala Gly Thr Ser Leu Asp Arg Leu 
    370                 375                 380                 


Val Thr Asp Ile Lys Glu Lys Leu Lys Leu Ser Lys Lys Val Trp Ser 
385                 390                 395                 400 


Ala Leu Pro Tyr Thr Ile Cys Lys Asp Glu Ser Val Thr Ala Gly Thr 
                405                 410                 415     


Ser Asn Glu Glu Glu Cys Trp Asn Gly His Ser Lys Ala Arg Tyr Leu 
            420                 425                 430         


Pro Glu Ile Met Asn Asp Gly Leu Thr Asn Gln Ile Asn Asn Pro Glu 
        435                 440                 445             


Val Asp Val Asp Ile Thr Arg Pro Asp Thr Phe Ile Arg Gln Gln Ile 
    450                 455                 460                 


Met Ala Leu Arg Val Met Thr Asn Lys Leu Lys Asn Ala Tyr Asn Gly 
465                 470                 475                 480 


Asn Asp Val Asn Phe Gln Asp Thr Ser Asp Glu Ser Ser Gly Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Cys Met Asp Asp Val Cys Pro Thr Glu Phe Glu Phe 
            500                 505                 510         


Val Thr Thr Glu Ala Pro Ala Val Asp Pro Asp Arg Arg Glu Val Asp 
        515                 520                 525             


Ser Ser Ala Ala Gln Arg Gly His Ser Leu Leu Ser Trp Ser Leu Thr 
    530                 535                 540                 


Cys Ile Val Leu Ala Leu Gln Arg Leu Cys Arg 
545                 550                 555 


<210>  4617
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPCPD1__Homo_sapiens__NP_062539

<400>  4617

Met Thr Pro Ser Gln Val Ala Phe Glu Ile Arg Gly Thr Leu Leu Pro 
1               5                   10                  15      


Gly Glu Val Phe Ala Ile Cys Gly Ser Cys Asp Ala Leu Gly Asn Trp 
            20                  25                  30          


Asn Pro Gln Asn Ala Val Ala Leu Leu Pro Glu Asn Asp Thr Gly Glu 
        35                  40                  45              


Ser Met Leu Trp Lys Ala Thr Ile Val Leu Ser Arg Gly Val Ser Val 
    50                  55                  60                  


Gln Tyr Arg Tyr Phe Lys Gly Tyr Phe Leu Glu Pro Lys Thr Ile Gly 
65                  70                  75                  80  


Gly Pro Cys Gln Val Ile Val His Lys Trp Glu Thr His Leu Gln Pro 
                85                  90                  95      


Arg Ser Ile Thr Pro Leu Glu Ser Glu Ile Ile Ile Asp Asp Gly Gln 
            100                 105                 110         


Phe Gly Ile His Asn Gly Val Glu Thr Leu Asp Ser Gly Trp Leu Thr 
        115                 120                 125             


Cys Gln Thr Glu Ile Arg Leu Arg Leu His Tyr Ser Glu Lys Pro Pro 
    130                 135                 140                 


Val Ser Ile Thr Lys Lys Lys Leu Lys Lys Ser Arg Phe Arg Val Lys 
145                 150                 155                 160 


Leu Thr Leu Glu Gly Leu Glu Glu Asp Asp Asp Asp Arg Val Ser Pro 
                165                 170                 175     


Thr Val Leu His Lys Met Ser Asn Ser Leu Glu Ile Ser Leu Ile Ser 
            180                 185                 190         


Asp Asn Glu Phe Lys Cys Arg His Ser Gln Pro Glu Cys Gly Tyr Gly 
        195                 200                 205             


Leu Gln Pro Asp Arg Trp Thr Glu Tyr Ser Ile Gln Thr Met Glu Pro 
    210                 215                 220                 


Asp Asn Leu Glu Leu Ile Phe Asp Phe Phe Glu Glu Asp Leu Ser Glu 
225                 230                 235                 240 


His Val Val Gln Gly Asp Ala Leu Pro Gly His Val Gly Thr Ala Cys 
                245                 250                 255     


Leu Leu Ser Ser Thr Ile Ala Glu Ser Gly Lys Ser Ala Gly Ile Leu 
            260                 265                 270         


Thr Leu Pro Ile Met Ser Arg Asn Ser Arg Lys Thr Ile Gly Lys Val 
        275                 280                 285             


Arg Val Asp Tyr Ile Ile Ile Lys Pro Leu Pro Gly Tyr Ser Cys Asp 
    290                 295                 300                 


Met Lys Ser Ser Phe Ser Lys Tyr Trp Lys Pro Arg Ile Pro Leu Asp 
305                 310                 315                 320 


Val Gly His Arg Gly Ala Gly Asn Ser Thr Thr Thr Ala Gln Leu Ala 
                325                 330                 335     


Lys Val Gln Glu Asn Thr Ile Ala Ser Leu Arg Asn Ala Ala Ser His 
            340                 345                 350         


Gly Ala Ala Phe Val Glu Phe Asp Val His Leu Ser Lys Asp Phe Val 
        355                 360                 365             


Pro Val Val Tyr His Asp Leu Thr Cys Cys Leu Thr Met Lys Lys Lys 
    370                 375                 380                 


Phe Asp Ala Asp Pro Val Glu Leu Phe Glu Ile Pro Val Lys Glu Leu 
385                 390                 395                 400 


Thr Phe Asp Gln Leu Gln Leu Leu Lys Leu Thr His Val Thr Ala Leu 
                405                 410                 415     


Lys Ser Lys Asp Arg Lys Glu Ser Val Val Gln Glu Glu Asn Ser Phe 
            420                 425                 430         


Ser Glu Asn Gln Pro Phe Pro Ser Leu Lys Met Val Leu Glu Ser Leu 
        435                 440                 445             


Pro Glu Asp Val Gly Phe Asn Ile Glu Ile Lys Trp Ile Cys Gln Gln 
    450                 455                 460                 


Arg Asp Gly Met Trp Asp Gly Asn Leu Ser Thr Tyr Phe Asp Met Asn 
465                 470                 475                 480 


Leu Phe Leu Asp Ile Ile Leu Lys Thr Val Leu Glu Asn Ser Gly Lys 
                485                 490                 495     


Arg Arg Ile Val Phe Ser Ser Phe Asp Ala Asp Ile Cys Thr Met Val 
            500                 505                 510         


Arg Gln Lys Gln Asn Lys Tyr Pro Ile Leu Phe Leu Thr Gln Gly Lys 
        515                 520                 525             


Ser Glu Ile Tyr Pro Glu Leu Met Asp Leu Arg Ser Arg Thr Thr Pro 
    530                 535                 540                 


Ile Ala Met Ser Phe Ala Gln Phe Glu Asn Leu Leu Gly Ile Asn Val 
545                 550                 555                 560 


His Thr Glu Asp Leu Leu Arg Asn Pro Ser Tyr Ile Gln Glu Ala Lys 
                565                 570                 575     


Ala Lys Gly Leu Val Ile Phe Cys Trp Gly Asp Asp Thr Asn Asp Pro 
            580                 585                 590         


Glu Asn Arg Arg Lys Leu Lys Glu Leu Gly Val Asn Gly Leu Ile Tyr 
        595                 600                 605             


Asp Arg Ile Tyr Asp Trp Met Pro Glu Gln Pro Asn Ile Phe Gln Val 
    610                 615                 620                 


Glu Gln Leu Glu Arg Leu Lys Gln Glu Leu Pro Glu Leu Lys Ser Cys 
625                 630                 635                 640 


Leu Cys Pro Thr Val Ser Arg Phe Val Pro Ser Ser Leu Cys Gly Glu 
                645                 650                 655     


Ser Asp Ile His Val Asp Ala Asn Gly Ile Asp Asn Val Glu Asn Ala 
            660                 665                 670         


<210>  4618
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPD1__Homo_sapiens__NP_001244128

<400>  4618

Met Ala Ser Lys Lys Val Cys Ile Val Gly Ser Gly Asn Trp Gly Ser 
1               5                   10                  15      


Ala Ile Ala Lys Ile Val Gly Gly Asn Ala Ala Gln Leu Ala Gln Phe 
            20                  25                  30          


Asp Pro Arg Val Thr Met Trp Val Phe Glu Glu Asp Ile Gly Gly Lys 
        35                  40                  45              


Lys Leu Thr Glu Ile Ile Asn Thr Gln His Glu Asn Val Lys Tyr Leu 
    50                  55                  60                  


Pro Gly His Lys Leu Pro Pro Asn Val Phe Ile Gly Lys Ile Cys Asp 
65                  70                  75                  80  


Gln Leu Lys Gly His Leu Lys Ala Asn Ala Thr Gly Ile Ser Leu Ile 
                85                  90                  95      


Lys Gly Val Asp Glu Gly Pro Asn Gly Leu Lys Leu Ile Ser Glu Val 
            100                 105                 110         


Ile Gly Glu Arg Leu Gly Ile Pro Met Ser Val Leu Met Gly Ala Asn 
        115                 120                 125             


Ile Ala Ser Glu Val Ala Asp Glu Lys Phe Cys Glu Thr Thr Ile Gly 
    130                 135                 140                 


Cys Lys Asp Pro Ala Gln Gly Gln Leu Leu Lys Glu Leu Met Gln Thr 
145                 150                 155                 160 


Pro Asn Phe Arg Ile Thr Val Val Gln Glu Val Asp Thr Val Glu Ile 
                165                 170                 175     


Cys Gly Ala Leu Lys Asn Val Val Ala Val Gly Ala Gly Phe Cys Asp 
            180                 185                 190         


Gly Leu Gly Phe Gly Asp Asn Thr Lys Ala Ala Val Ile Arg Leu Gly 
        195                 200                 205             


Leu Met Glu Met Ile Ala Phe Ala Lys Leu Phe Cys Ser Gly Pro Val 
    210                 215                 220                 


Ser Ser Ala Thr Phe Leu Glu Ser Cys Gly Val Ala Asp Leu Ile Thr 
225                 230                 235                 240 


Thr Cys Tyr Gly Gly Arg Asn Arg Lys Val Ala Glu Ala Phe Ala Arg 
                245                 250                 255     


Thr Gly Lys Ser Ile Glu Gln Leu Glu Lys Glu Leu Leu Asn Gly Gln 
            260                 265                 270         


Lys Leu Gln Gly Pro Glu Thr Ala Arg Glu Leu Tyr Ser Ile Leu Gln 
        275                 280                 285             


His Lys Gly Leu Val Asp Lys Phe Pro Leu Phe Met Ala Val Tyr Lys 
    290                 295                 300                 


Val Cys Tyr Glu Gly Gln Pro Val Gly Glu Phe Ile His Cys Leu Gln 
305                 310                 315                 320 


Asn His Pro Glu His Met 
                325     


<210>  4619
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPD1L__Homo_sapiens__NP_055956

<400>  4619

Met Ala Ala Ala Pro Leu Lys Val Cys Ile Val Gly Ser Gly Asn Trp 
1               5                   10                  15      


Gly Ser Ala Val Ala Lys Ile Ile Gly Asn Asn Val Lys Lys Leu Gln 
            20                  25                  30          


Lys Phe Ala Ser Thr Val Lys Met Trp Val Phe Glu Glu Thr Val Asn 
        35                  40                  45              


Gly Arg Lys Leu Thr Asp Ile Ile Asn Asn Asp His Glu Asn Val Lys 
    50                  55                  60                  


Tyr Leu Pro Gly His Lys Leu Pro Glu Asn Val Val Ala Met Ser Asn 
65                  70                  75                  80  


Leu Ser Glu Ala Val Gln Asp Ala Asp Leu Leu Val Phe Val Ile Pro 
                85                  90                  95      


His Gln Phe Ile His Arg Ile Cys Asp Glu Ile Thr Gly Arg Val Pro 
            100                 105                 110         


Lys Lys Ala Leu Gly Ile Thr Leu Ile Lys Gly Ile Asp Glu Gly Pro 
        115                 120                 125             


Glu Gly Leu Lys Leu Ile Ser Asp Ile Ile Arg Glu Lys Met Gly Ile 
    130                 135                 140                 


Asp Ile Ser Val Leu Met Gly Ala Asn Ile Ala Asn Glu Val Ala Ala 
145                 150                 155                 160 


Glu Lys Phe Cys Glu Thr Thr Ile Gly Ser Lys Val Met Glu Asn Gly 
                165                 170                 175     


Leu Leu Phe Lys Glu Leu Leu Gln Thr Pro Asn Phe Arg Ile Thr Val 
            180                 185                 190         


Val Asp Asp Ala Asp Thr Val Glu Leu Cys Gly Ala Leu Lys Asn Ile 
        195                 200                 205             


Val Ala Val Gly Ala Gly Phe Cys Asp Gly Leu Arg Cys Gly Asp Asn 
    210                 215                 220                 


Thr Lys Ala Ala Val Ile Arg Leu Gly Leu Met Glu Met Ile Ala Phe 
225                 230                 235                 240 


Ala Arg Ile Phe Cys Lys Gly Gln Val Ser Thr Ala Thr Phe Leu Glu 
                245                 250                 255     


Ser Cys Gly Val Ala Asp Leu Ile Thr Thr Cys Tyr Gly Gly Arg Asn 
            260                 265                 270         


Arg Arg Val Ala Glu Ala Phe Ala Arg Thr Gly Lys Thr Ile Glu Glu 
        275                 280                 285             


Leu Glu Lys Glu Met Leu Asn Gly Gln Lys Leu Gln Gly Pro Gln Thr 
    290                 295                 300                 


Ser Ala Glu Val Tyr Arg Ile Leu Lys Gln Lys Gly Leu Leu Asp Lys 
305                 310                 315                 320 


Phe Pro Leu Phe Thr Ala Val Tyr Gln Ile Cys Tyr Glu Ser Arg Pro 
                325                 330                 335     


Val Gln Glu Met Leu Ser Cys Leu Gln Ser His Pro Glu His Thr 
            340                 345                 350     


<210>  4620
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPD2__Homo_sapiens__NP_001076581

<400>  4620

Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly 
1               5                   10                  15      


Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg 
            20                  25                  30          


Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu 
        35                  40                  45              


Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu 
    50                  55                  60                  


Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala 
                85                  90                  95      


Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr 
            100                 105                 110         


Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys 
        115                 120                 125             


Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg 
    130                 135                 140                 


Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly 
                165                 170                 175     


Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser 
            180                 185                 190         


Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln 
        195                 200                 205             


Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn 
    210                 215                 220                 


Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly 
225                 230                 235                 240 


Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr 
                245                 250                 255     


Asp Pro Gln Thr Gly Lys Val Arg Val Ser Gly Ala Arg Cys Lys Asp 
            260                 265                 270         


Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn 
        275                 280                 285             


Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp 
    290                 295                 300                 


Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro 
305                 310                 315                 320 


Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser 
                325                 330                 335     


Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala 
            340                 345                 350         


Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser 
        355                 360                 365             


Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser 
    370                 375                 380                 


Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly 
385                 390                 395                 400 


Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile 
                405                 410                 415     


Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile 
            420                 425                 430         


Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile 
        435                 440                 445             


Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr 
    450                 455                 460                 


Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr 
465                 470                 475                 480 


Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His 
                485                 490                 495     


Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala 
            500                 505                 510         


Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val Arg Leu Val Ser 
        515                 520                 525             


Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr 
    530                 535                 540                 


Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe 
545                 550                 555                 560 


Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu 
                565                 570                 575     


Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu 
            580                 585                 590         


Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg 
        595                 600                 605             


Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp 
    610                 615                 620                 


Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys 
625                 630                 635                 640 


Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn 
                645                 650                 655     


Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp 
            660                 665                 670         


Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met 
        675                 680                 685             


Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu 
    690                 695                 700                 


Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val 
705                 710                 715                 720 


Asp Arg Ser Cys Gly Gly Leu 
                725         


<210>  4621
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPER1__Homo_sapiens__NP_001091671

<400>  4621

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  4622
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPHA2__Homo_sapiens__NP_570125

<400>  4622

Met Pro Met Ala Ser Pro Gln Thr Leu Val Leu Tyr Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Thr Glu Ala Trp Gly Gln Glu Ala Val Ile Pro Gly Cys His 
            20                  25                  30          


Leu His Pro Phe Asn Val Thr Val Arg Ser Asp Arg Gln Gly Thr Cys 
        35                  40                  45              


Gln Gly Ser His Val Ala Gln Ala Cys Val Gly His Cys Glu Ser Ser 
    50                  55                  60                  


Ala Phe Pro Ser Arg Tyr Ser Val Leu Val Ala Ser Gly Tyr Arg His 
65                  70                  75                  80  


Asn Ile Thr Ser Val Ser Gln Cys Cys Thr Ile Ser Gly Leu Lys Lys 
                85                  90                  95      


Val Lys Val Gln Leu Gln Cys Val Gly Ser Arg Arg Glu Glu Leu Glu 
            100                 105                 110         


Ile Phe Thr Ala Arg Ala Cys Gln Cys Asp Met Cys Arg Leu Ser Arg 
        115                 120                 125             


Tyr 
    


<210>  4623
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPHN__Homo_sapiens__NP_001019389

<400>  4623

Met Ala Thr Glu Gly Met Ile Leu Thr Asn His Asp His Gln Ile Arg 
1               5                   10                  15      


Val Gly Val Leu Thr Val Ser Asp Ser Cys Phe Arg Asn Leu Ala Glu 
            20                  25                  30          


Asp Arg Ser Gly Ile Asn Leu Lys Asp Leu Val Gln Asp Pro Ser Leu 
        35                  40                  45              


Leu Gly Gly Thr Ile Ser Ala Tyr Lys Ile Val Pro Asp Glu Ile Glu 
    50                  55                  60                  


Glu Ile Lys Glu Thr Leu Ile Asp Trp Cys Asp Glu Lys Glu Leu Asn 
65                  70                  75                  80  


Leu Ile Leu Thr Thr Gly Gly Thr Gly Phe Ala Pro Arg Asp Val Thr 
                85                  90                  95      


Pro Glu Ala Thr Lys Glu Val Ile Glu Arg Glu Ala Pro Gly Met Ala 
            100                 105                 110         


Leu Ala Met Leu Met Gly Ser Leu Asn Val Thr Pro Leu Gly Met Leu 
        115                 120                 125             


Ser Arg Pro Val Cys Gly Ile Arg Gly Lys Thr Leu Ile Ile Asn Leu 
    130                 135                 140                 


Pro Gly Ser Lys Lys Gly Ser Gln Glu Cys Phe Gln Phe Ile Leu Pro 
145                 150                 155                 160 


Ala Leu Pro His Ala Ile Asp Leu Leu Arg Asp Ala Ile Val Lys Val 
                165                 170                 175     


Lys Glu Val His Asp Glu Leu Glu Asp Leu Pro Ser Pro Pro Pro Pro 
            180                 185                 190         


Leu Ser Pro Pro Pro Thr Thr Ser Pro His Lys Gln Thr Glu Asp Lys 
        195                 200                 205             


Gly Val Gln Cys Glu Glu Glu Glu Glu Glu Lys Lys Asp Ser Gly Val 
    210                 215                 220                 


Ala Ser Thr Glu Asp Ser Ser Ser Ser His Ile Thr Ala Ala Ala Ile 
225                 230                 235                 240 


Ala Ala Lys Ile Pro Asp Ser Ile Ile Ser Arg Gly Val Gln Val Leu 
                245                 250                 255     


Pro Arg Asp Thr Ala Ser Leu Ser Thr Thr Pro Ser Glu Ser Pro Arg 
            260                 265                 270         


Ala Gln Ala Thr Ser Arg Leu Ser Thr Ala Ser Cys Pro Thr Pro Lys 
        275                 280                 285             


Val Gln Ser Arg Cys Ser Ser Lys Glu Asn Ile Leu Arg Ala Ser His 
    290                 295                 300                 


Ser Ala Val Asp Ile Thr Lys Val Ala Arg Arg His Arg Met Ser Pro 
305                 310                 315                 320 


Phe Pro Leu Thr Ser Met Asp Lys Ala Phe Ile Thr Val Leu Glu Met 
                325                 330                 335     


Thr Pro Val Leu Gly Thr Glu Ile Ile Asn Tyr Arg Asp Gly Met Gly 
            340                 345                 350         


Arg Val Leu Ala Gln Asp Val Tyr Ala Lys Asp Asn Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Ser Val Lys Asp Gly Tyr Ala Val Arg Ala Ala Asp Gly Pro 
    370                 375                 380                 


Gly Asp Arg Phe Ile Ile Gly Glu Ser Gln Ala Gly Glu Gln Pro Thr 
385                 390                 395                 400 


Gln Thr Val Met Pro Gly Gln Val Met Arg Val Thr Thr Gly Ala Pro 
                405                 410                 415     


Ile Pro Cys Gly Ala Asp Ala Val Val Gln Val Glu Asp Thr Glu Leu 
            420                 425                 430         


Ile Arg Glu Ser Asp Asp Gly Thr Glu Glu Leu Glu Val Arg Ile Leu 
        435                 440                 445             


Val Gln Ala Arg Pro Gly Gln Asp Ile Arg Pro Ile Gly His Asp Ile 
    450                 455                 460                 


Lys Arg Gly Glu Cys Val Leu Ala Lys Gly Thr His Met Gly Pro Ser 
465                 470                 475                 480 


Glu Ile Gly Leu Leu Ala Thr Val Gly Val Thr Glu Val Glu Val Asn 
                485                 490                 495     


Lys Phe Pro Val Val Ala Val Met Ser Thr Gly Asn Glu Leu Leu Asn 
            500                 505                 510         


Pro Glu Asp Asp Leu Leu Pro Gly Lys Ile Arg Asp Ser Asn Arg Ser 
        515                 520                 525             


Thr Leu Leu Ala Thr Ile Gln Glu His Gly Tyr Pro Thr Ile Asn Leu 
    530                 535                 540                 


Gly Ile Val Gly Asp Asn Pro Asp Asp Leu Leu Asn Ala Leu Asn Glu 
545                 550                 555                 560 


Gly Ile Ser Arg Ala Asp Val Ile Ile Thr Ser Gly Gly Val Ser Met 
                565                 570                 575     


Gly Glu Lys Asp Tyr Leu Lys Gln Val Leu Asp Ile Asp Leu His Ala 
            580                 585                 590         


Gln Ile His Phe Gly Arg Val Phe Met Lys Pro Gly Leu Pro Thr Thr 
        595                 600                 605             


Phe Ala Thr Leu Asp Ile Asp Gly Val Arg Lys Ile Ile Phe Ala Leu 
    610                 615                 620                 


Pro Gly Asn Pro Val Ser Ala Val Val Thr Cys Asn Leu Phe Val Val 
625                 630                 635                 640 


Pro Ala Leu Arg Lys Met Gln Gly Ile Leu Asp Pro Arg Pro Thr Ile 
                645                 650                 655     


Ile Lys Ala Arg Leu Ser Cys Asp Val Lys Leu Asp Pro Arg Pro Glu 
            660                 665                 670         


Tyr His Arg Cys Ile Leu Thr Trp His His Gln Glu Pro Leu Pro Trp 
        675                 680                 685             


Ala Gln Ser Thr Gly Asn Gln Met Ser Ser Arg Leu Met Ser Met Arg 
    690                 695                 700                 


Ser Ala Asn Gly Leu Leu Met Leu Pro Pro Lys Thr Glu Gln Tyr Val 
705                 710                 715                 720 


Glu Leu His Lys Gly Glu Val Val Asp Val Met Val Ile Gly Arg Leu 
                725                 730                 735     


<210>  4624
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPIHBP1__Homo_sapiens__NP_835466

<400>  4624

Met Lys Ala Leu Gly Ala Val Leu Leu Ala Leu Leu Leu Phe Gly Arg 
1               5                   10                  15      


Pro Gly Arg Gly Gln Thr Gln Gln Glu Glu Glu Glu Glu Asp Glu Asp 
            20                  25                  30          


His Gly Pro Asp Asp Tyr Asp Glu Glu Asp Glu Asp Glu Val Glu Glu 
        35                  40                  45              


Glu Glu Thr Asn Arg Leu Pro Gly Gly Arg Ser Arg Val Leu Leu Arg 
    50                  55                  60                  


Cys Tyr Thr Cys Lys Ser Leu Pro Arg Asp Glu Arg Cys Asn Leu Thr 
65                  70                  75                  80  


Gln Asn Cys Ser His Gly Gln Thr Cys Thr Thr Leu Ile Ala His Gly 
                85                  90                  95      


Asn Thr Glu Ser Gly Leu Leu Thr Thr His Ser Thr Trp Cys Thr Asp 
            100                 105                 110         


Ser Cys Gln Pro Ile Thr Lys Thr Val Glu Gly Thr Gln Val Thr Met 
        115                 120                 125             


Thr Cys Cys Gln Ser Ser Leu Cys Asn Val Pro Pro Trp Gln Ser Ser 
    130                 135                 140                 


Arg Val Gln Asp Pro Thr Gly Lys Gly Ala Gly Gly Pro Arg Gly Ser 
145                 150                 155                 160 


Ser Glu Thr Val Gly Ala Ala Leu Leu Leu Asn Leu Leu Ala Gly Leu 
                165                 170                 175     


Gly Ala Met Gly Ala Arg Arg Pro 
            180                 


<210>  4625
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPI__Homo_sapiens__NP_001171651

<400>  4625

Met Val Ala Leu Cys Ser Leu Gln His Leu Gly Ser Ser Asp Pro Arg 
1               5                   10                  15      


Ala Leu Pro Thr Leu Pro Thr Ala Thr Ser Gly Gln Arg Pro Ala Lys 
            20                  25                  30          


Arg Arg Arg Lys Ser Pro Ala Met Ala Ala Leu Thr Arg Asp Pro Gln 
        35                  40                  45              


Phe Gln Lys Leu Gln Gln Trp Tyr Arg Glu His Arg Ser Glu Leu Asn 
    50                  55                  60                  


Leu Arg Arg Leu Phe Asp Ala Asn Lys Asp Arg Phe Asn His Phe Ser 
65                  70                  75                  80  


Leu Thr Leu Asn Thr Asn His Gly His Ile Leu Val Asp Tyr Ser Lys 
                85                  90                  95      


Asn Leu Val Thr Glu Asp Val Met Arg Met Leu Val Asp Leu Ala Lys 
            100                 105                 110         


Ser Arg Gly Val Glu Ala Ala Arg Glu Arg Met Phe Asn Gly Glu Lys 
        115                 120                 125             


Ile Asn Tyr Thr Glu Gly Arg Ala Val Leu His Val Ala Leu Arg Asn 
    130                 135                 140                 


Arg Ser Asn Thr Pro Ile Leu Val Asp Gly Lys Asp Val Met Pro Glu 
145                 150                 155                 160 


Val Asn Lys Val Leu Asp Lys Met Lys Ser Phe Cys Gln Gly Pro Leu 
                165                 170                 175     


Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser Gly Gly Pro Arg Val 
            180                 185                 190         


Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile Ala Lys Thr Leu Ala 
        195                 200                 205             


Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile Ala Ser Lys Thr Phe 
    210                 215                 220                 


Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr Ala Lys Glu Trp Phe 
225                 230                 235                 240 


Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala Lys His Phe Val Ala 
                245                 250                 255     


Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe Gly Ile Asp Pro Gln 
            260                 265                 270         


Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly Arg Tyr Ser Leu Trp 
        275                 280                 285             


Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val Gly Phe Asp Asn Phe 
    290                 295                 300                 


Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp Gln His Phe Arg Thr 
305                 310                 315                 320 


Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu Ala Leu Leu Gly Ile 
                325                 330                 335     


Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His Ala Met Leu Pro Tyr 
            340                 345                 350         


Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe Gln Gln Gly Asp Met 
        355                 360                 365             


Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly Thr Arg Val Asp His 
    370                 375                 380                 


Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly Thr Asn Gly Gln His 
385                 390                 395                 400 


Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys Met Ile Pro Cys Asp 
                405                 410                 415     


Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile Arg Lys Gly Leu His 
            420                 425                 430         


His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln Thr Glu Ala Leu Met 
        435                 440                 445             


Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu Leu Gln Ala Ala Gly 
    450                 455                 460                 


Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro His Lys Val Phe Glu 
465                 470                 475                 480 


Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr Lys Leu Thr Pro Phe 
                485                 490                 495     


Met Leu Gly Ala Leu Val Ala Met Tyr Glu His Lys Ile Phe Val Gln 
            500                 505                 510         


Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln Trp Gly Val Glu Leu 
        515                 520                 525             


Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu Leu Asp Gly Ser Ala 
    530                 535                 540                 


Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly Leu Ile Asn Phe Ile 
545                 550                 555                 560 


Lys Gln Gln Arg Glu Ala Arg Val Gln 
                565                 


<210>  4626
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPKOW__Homo_sapiens__NP_056513

<400>  4626

Met Ala Asp Ser Lys Glu Gly Val Leu Pro Leu Thr Ala Ala Ser Thr 
1               5                   10                  15      


Ala Pro Ile Ser Phe Gly Phe Thr Arg Thr Ser Ala Arg Arg Arg Leu 
            20                  25                  30          


Ala Asp Ser Gly Asp Gly Ala Gly Pro Ser Pro Glu Glu Lys Asp Phe 
        35                  40                  45              


Leu Lys Thr Val Glu Gly Arg Glu Leu Gln Ser Val Lys Pro Gln Glu 
    50                  55                  60                  


Ala Pro Lys Glu Leu Val Ile Pro Leu Ile Gln Asn Gly His Arg Arg 
65                  70                  75                  80  


Gln Pro Pro Ala Arg Pro Pro Gly Pro Ser Thr Asp Thr Gly Ala Leu 
                85                  90                  95      


Ala Asp Gly Val Val Ser Gln Ala Val Lys Glu Leu Ile Ala Glu Ser 
            100                 105                 110         


Lys Lys Ser Leu Glu Glu Arg Glu Asn Ala Gly Val Asp Pro Thr Leu 
        115                 120                 125             


Ala Ile Pro Met Ile Gln Lys Gly Cys Thr Pro Ser Gly Glu Gly Ala 
    130                 135                 140                 


Asp Ser Glu Pro Arg Ala Glu Thr Val Pro Glu Glu Ala Asn Tyr Glu 
145                 150                 155                 160 


Ala Val Pro Val Glu Ala Tyr Gly Leu Ala Met Leu Arg Gly Met Gly 
                165                 170                 175     


Trp Lys Pro Gly Glu Gly Ile Gly Arg Thr Phe Asn Gln Val Val Lys 
            180                 185                 190         


Pro Arg Val Asn Ser Leu Arg Pro Lys Gly Leu Gly Leu Gly Ala Asn 
        195                 200                 205             


Leu Thr Glu Ala Gln Ala Leu Thr Pro Thr Gly Pro Ser Arg Met Pro 
    210                 215                 220                 


Arg Pro Asp Glu Glu Gln Glu Lys Asp Lys Glu Asp Gln Pro Gln Gly 
225                 230                 235                 240 


Leu Val Pro Gly Gly Ala Val Val Val Leu Ser Gly Pro His Arg Gly 
                245                 250                 255     


Leu Tyr Gly Lys Val Glu Gly Leu Asp Pro Asp Asn Val Arg Ala Met 
            260                 265                 270         


Val Arg Leu Ala Val Gly Ser Arg Val Val Thr Val Ser Glu Tyr Tyr 
        275                 280                 285             


Leu Arg Pro Val Ser Gln Gln Glu Phe Asp Lys Asn Thr Leu Asp Leu 
    290                 295                 300                 


Arg Gln Gln Asn Gly Thr Ala Ser Ser Arg Lys Thr Leu Trp Asn Gln 
305                 310                 315                 320 


Glu Leu Tyr Ile Gln Gln Asp Asn Ser Glu Arg Lys Arg Lys His Leu 
                325                 330                 335     


Pro Asp Arg Gln Asp Gly Pro Ala Ala Lys Ser Glu Lys Ala Ala Pro 
            340                 345                 350         


Arg Ser Gln His Trp Leu His Arg Asp Leu Arg Val Arg Phe Val Asp 
        355                 360                 365             


Asn Met Tyr Lys Gly Gly Gln Tyr Tyr Asn Thr Lys Met Ile Ile Glu 
    370                 375                 380                 


Asp Val Leu Ser Pro Asp Thr Cys Val Cys Arg Thr Asp Glu Gly Arg 
385                 390                 395                 400 


Val Leu Glu Gly Leu Arg Glu Asp Met Leu Glu Thr Leu Val Pro Lys 
                405                 410                 415     


Ala Glu Gly Asp Arg Val Met Val Val Leu Gly Pro Gln Thr Gly Arg 
            420                 425                 430         


Val Gly His Leu Leu Ser Arg Asp Arg Ala Arg Ser Arg Ala Leu Val 
        435                 440                 445             


Gln Leu Pro Arg Glu Asn Gln Val Val Glu Leu His Tyr Asp Ala Ile 
    450                 455                 460                 


Cys Gln Tyr Met Gly Pro Ser Asp Thr Asp Asp Asp 
465                 470                 475     


<210>  4627
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPLD1__Homo_sapiens__NP_001494

<400>  4627

Met Ser Ala Phe Arg Leu Trp Pro Gly Leu Leu Ile Met Leu Gly Ser 
1               5                   10                  15      


Leu Cys His Arg Gly Ser Pro Cys Gly Leu Ser Thr His Val Glu Ile 
            20                  25                  30          


Gly His Arg Ala Leu Glu Phe Leu Gln Leu His Asn Gly Arg Val Asn 
        35                  40                  45              


Tyr Arg Glu Leu Leu Leu Glu His Gln Asp Ala Tyr Gln Ala Gly Ile 
    50                  55                  60                  


Val Phe Pro Asp Cys Phe Tyr Pro Ser Ile Cys Lys Gly Gly Lys Phe 
65                  70                  75                  80  


His Asp Val Ser Glu Ser Thr His Trp Thr Pro Phe Leu Asn Ala Ser 
                85                  90                  95      


Val His Tyr Ile Arg Glu Asn Tyr Pro Leu Pro Trp Glu Lys Asp Thr 
            100                 105                 110         


Glu Lys Leu Val Ala Phe Leu Phe Gly Ile Thr Ser His Met Ala Ala 
        115                 120                 125             


Asp Val Ser Trp His Ser Leu Gly Leu Glu Gln Gly Phe Leu Arg Thr 
    130                 135                 140                 


Met Gly Ala Ile Asp Phe His Gly Ser Tyr Ser Glu Ala His Ser Ala 
145                 150                 155                 160 


Gly Asp Phe Gly Gly Asp Val Leu Ser Gln Phe Glu Phe Asn Phe Asn 
                165                 170                 175     


Tyr Leu Ala Arg Arg Trp Tyr Val Pro Val Lys Asp Leu Leu Gly Ile 
            180                 185                 190         


Tyr Glu Lys Leu Tyr Gly Arg Lys Val Ile Thr Glu Asn Val Ile Val 
        195                 200                 205             


Asp Cys Ser His Ile Gln Phe Leu Glu Met Tyr Gly Glu Met Leu Ala 
    210                 215                 220                 


Val Ser Lys Leu Tyr Pro Thr Tyr Ser Thr Lys Ser Pro Phe Leu Val 
225                 230                 235                 240 


Glu Gln Phe Gln Glu Tyr Phe Leu Gly Gly Leu Asp Asp Met Ala Phe 
                245                 250                 255     


Trp Ser Thr Asn Ile Tyr His Leu Thr Ser Phe Met Leu Glu Asn Gly 
            260                 265                 270         


Thr Ser Asp Cys Asn Leu Pro Glu Asn Pro Leu Phe Ile Ala Cys Gly 
        275                 280                 285             


Gly Gln Gln Asn His Thr Gln Gly Ser Lys Met Gln Lys Asn Asp Phe 
    290                 295                 300                 


His Arg Asn Leu Thr Thr Ser Leu Thr Glu Ser Val Asp Arg Asn Ile 
305                 310                 315                 320 


Asn Tyr Thr Glu Arg Gly Val Phe Phe Ser Val Asn Ser Trp Thr Pro 
                325                 330                 335     


Asp Ser Met Ser Phe Ile Tyr Lys Ala Leu Glu Arg Asn Ile Arg Thr 
            340                 345                 350         


Met Phe Ile Gly Gly Ser Gln Leu Ser Gln Lys His Val Ser Ser Pro 
        355                 360                 365             


Leu Ala Ser Tyr Phe Leu Ser Phe Pro Tyr Ala Arg Leu Gly Trp Ala 
    370                 375                 380                 


Met Thr Ser Ala Asp Leu Asn Gln Asp Gly His Gly Asp Leu Val Val 
385                 390                 395                 400 


Gly Ala Pro Gly Tyr Ser Arg Pro Gly His Ile His Ile Gly Arg Val 
                405                 410                 415     


Tyr Leu Ile Tyr Gly Asn Asp Leu Gly Leu Pro Pro Val Asp Leu Asp 
            420                 425                 430         


Leu Asp Lys Glu Ala His Arg Ile Leu Glu Gly Phe Gln Pro Ser Gly 
        435                 440                 445             


Arg Phe Gly Ser Ala Leu Ala Val Leu Asp Phe Asn Val Asp Gly Val 
    450                 455                 460                 


Pro Asp Leu Ala Val Gly Ala Pro Ser Val Gly Ser Glu Gln Leu Thr 
465                 470                 475                 480 


Tyr Lys Gly Ala Val Tyr Val Tyr Phe Gly Ser Lys Gln Gly Gly Met 
                485                 490                 495     


Ser Ser Ser Pro Asn Ile Thr Ile Ser Cys Gln Asp Ile Tyr Cys Asn 
            500                 505                 510         


Leu Gly Trp Thr Leu Leu Ala Ala Asp Val Asn Gly Asp Ser Glu Pro 
        515                 520                 525             


Asp Leu Val Ile Gly Ser Pro Phe Ala Pro Gly Gly Gly Lys Gln Lys 
    530                 535                 540                 


Gly Ile Val Ala Ala Phe Tyr Ser Gly Pro Ser Leu Ser Asp Lys Glu 
545                 550                 555                 560 


Lys Leu Asn Val Glu Ala Ala Asn Trp Thr Val Arg Gly Glu Glu Asp 
                565                 570                 575     


Phe Ser Trp Phe Gly Tyr Ser Leu His Gly Val Thr Val Asp Asn Arg 
            580                 585                 590         


Thr Leu Leu Leu Val Gly Ser Pro Thr Trp Lys Asn Ala Ser Arg Leu 
        595                 600                 605             


Gly His Leu Leu His Ile Arg Asp Glu Lys Lys Ser Leu Gly Arg Val 
    610                 615                 620                 


Tyr Gly Tyr Phe Pro Pro Asn Gly Gln Ser Trp Phe Thr Ile Ser Gly 
625                 630                 635                 640 


Asp Lys Ala Met Gly Lys Leu Gly Thr Ser Leu Ser Ser Gly His Val 
                645                 650                 655     


Leu Met Asn Gly Thr Leu Lys Gln Val Leu Leu Val Gly Ala Pro Thr 
            660                 665                 670         


Tyr Asp Asp Val Ser Lys Val Ala Phe Leu Thr Val Thr Leu His Gln 
        675                 680                 685             


Gly Gly Ala Thr Arg Met Tyr Ala Leu Thr Ser Asp Ala Gln Pro Leu 
    690                 695                 700                 


Leu Leu Ser Thr Phe Ser Gly Asp Arg Arg Phe Ser Arg Phe Gly Gly 
705                 710                 715                 720 


Val Leu His Leu Ser Asp Leu Asp Asp Asp Gly Leu Asp Glu Ile Ile 
                725                 730                 735     


Met Ala Ala Pro Leu Arg Ile Ala Asp Val Thr Ser Gly Leu Ile Gly 
            740                 745                 750         


Gly Glu Asp Gly Arg Val Tyr Val Tyr Asn Gly Lys Glu Thr Thr Leu 
        755                 760                 765             


Gly Asp Met Thr Gly Lys Cys Lys Ser Trp Ile Thr Pro Cys Pro Glu 
    770                 775                 780                 


Glu Lys Ala Gln Tyr Val Leu Ile Ser Pro Glu Ala Ser Ser Arg Phe 
785                 790                 795                 800 


Gly Ser Ser Leu Ile Thr Val Arg Ser Lys Ala Lys Asn Gln Val Val 
                805                 810                 815     


Ile Ala Ala Gly Arg Ser Ser Leu Gly Ala Arg Leu Ser Gly Ala Leu 
            820                 825                 830         


His Val Tyr Ser Leu Gly Ser Asp 
        835                 840 


<210>  4628
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPM6A__Homo_sapiens__NP_001248377

<400>  4628

Met Thr Asp Leu Glu Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly 
1               5                   10                  15      


Gly Ile Pro Tyr Ala Ser Leu Ile Ala Thr Ile Leu Leu Tyr Ala Gly 
            20                  25                  30          


Val Ala Leu Phe Cys Gly Cys Gly His Glu Ala Leu Ser Gly Thr Val 
        35                  40                  45              


Asn Ile Leu Gln Thr Tyr Phe Glu Met Ala Arg Thr Ala Gly Asp Thr 
    50                  55                  60                  


Leu Asp Val Phe Thr Met Ile Asp Ile Phe Lys Tyr Val Ile Tyr Gly 
65                  70                  75                  80  


Ile Ala Ala Ala Phe Phe Val Tyr Gly Ile Leu Leu Met Val Glu Gly 
                85                  90                  95      


Phe Phe Thr Thr Gly Ala Ile Lys Asp Leu Tyr Gly Asp Phe Lys Ile 
            100                 105                 110         


Thr Thr Cys Gly Arg Cys Val Ser Ala Trp Phe Ile Met Leu Thr Tyr 
        115                 120                 125             


Leu Phe Met Leu Ala Trp Leu Gly Val Thr Ala Phe Thr Ser Leu Pro 
    130                 135                 140                 


Val Tyr Met Tyr Phe Asn Leu Trp Thr Ile Cys Arg Asn Thr Thr Leu 
145                 150                 155                 160 


Val Glu Gly Ala Asn Leu Cys Leu Asp Leu Arg Gln Phe Gly Ile Val 
                165                 170                 175     


Thr Ile Gly Glu Glu Lys Lys Ile Cys Thr Val Ser Glu Asn Phe Leu 
            180                 185                 190         


Arg Met Cys Glu Ser Thr Glu Leu Asn Met Thr Phe His Leu Phe Ile 
        195                 200                 205             


Val Ala Leu Ala Gly Ala Gly Ala Ala Val Ile Ala Met Val His Tyr 
    210                 215                 220                 


Leu Met Val Leu Ser Ala Asn Trp Ala Tyr Val Lys Asp Ala Cys Arg 
225                 230                 235                 240 


Met Gln Lys Tyr Glu Asp Ile Lys Ser Lys Glu Glu Gln Glu Leu His 
                245                 250                 255     


Asp Ile His Ser Thr Arg Ser Lys Glu Arg Leu Asn Ala Tyr Thr 
            260                 265                 270     


<210>  4629
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPM6B__Homo_sapiens__NP_001001994

<400>  4629

Met Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly Val Pro Tyr 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Ile Leu Cys Phe Ser Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Val Ala Leu Ala Gly Thr Val Ala Ile Leu Glu 
        35                  40                  45              


Gln His Phe Ser Thr Asn Ala Ser Asp His Ala Leu Leu Ser Glu Val 
    50                  55                  60                  


Ile Gln Leu Met Gln Tyr Val Ile Tyr Gly Ile Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ile Ile Leu Leu Ala Glu Gly Phe Tyr Thr Thr Ser Ala 
                85                  90                  95      


Val Lys Glu Leu His Gly Glu Phe Lys Thr Thr Ala Cys Gly Arg Cys 
            100                 105                 110         


Ile Ser Gly Met Phe Val Phe Leu Thr Tyr Val Leu Gly Val Ala Trp 
        115                 120                 125             


Leu Gly Val Phe Gly Phe Ser Ala Val Pro Val Phe Met Phe Tyr Asn 
    130                 135                 140                 


Ile Trp Ser Thr Cys Glu Val Ile Lys Ser Pro Gln Thr Asn Gly Thr 
145                 150                 155                 160 


Thr Gly Val Glu Gln Ile Cys Val Asp Ile Arg Gln Tyr Gly Ile Ile 
                165                 170                 175     


Pro Trp Asn Ala Phe Pro Gly Lys Ile Cys Gly Ser Ala Leu Glu Asn 
            180                 185                 190         


Ile Cys Asn Thr Asn Glu Phe Tyr Met Ser Tyr His Leu Phe Ile Val 
        195                 200                 205             


Ala Cys Ala Gly Ala Gly Ala Thr Val Ile Ala Leu Leu Ile Tyr Met 
    210                 215                 220                 


Met Ala Thr Thr Tyr Asn Tyr Ala Val Leu Lys Phe Lys Ser Arg Glu 
225                 230                 235                 240 


Asp Cys Cys Thr Lys Phe 
                245     


<210>  4630
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPN1__Homo_sapiens__NP_001138519

<400>  4630

Met Thr Gly His Thr Arg Ser Ser Leu Pro Arg Cys Thr Gly Ile Val 
1               5                   10                  15      


Leu Leu Ile Lys Leu Arg Phe Ser Glu Arg Leu Thr Gly His Leu His 
            20                  25                  30          


Ala Gln Gly Thr Pro Pro Tyr Val Ile Asn Leu Asp Pro Ala Val His 
        35                  40                  45              


Glu Val Pro Phe Pro Ala Asn Ile Asp Ile Arg Asp Thr Val Lys Tyr 
    50                  55                  60                  


Lys Glu Val Met Lys Gln Tyr Gly Leu Gly Pro Asn Gly Gly Ile Val 
65                  70                  75                  80  


Thr Ser Leu Asn Leu Phe Ala Thr Arg Phe Asp Gln Val Met Lys Phe 
                85                  90                  95      


Ile Glu Lys Ala Gln Asn Met Ser Lys Tyr Val Leu Ile Asp Thr Pro 
            100                 105                 110         


Gly Gln Ile Glu Val Phe Thr Trp Ser Ala Ser Gly Thr Ile Ile Thr 
        115                 120                 125             


Glu Ala Leu Ala Ser Ser Phe Pro Thr Val Val Ile Tyr Val Met Asp 
    130                 135                 140                 


Thr Ser Arg Ser Thr Asn Pro Val Thr Phe Met Ser Asn Met Leu Tyr 
145                 150                 155                 160 


Ala Cys Ser Ile Leu Tyr Lys Thr Lys Leu Pro Phe Ile Val Val Met 
                165                 170                 175     


Asn Lys Thr Asp Ile Ile Asp His Ser Phe Ala Val Glu Trp Met Gln 
            180                 185                 190         


Asp Phe Glu Ala Phe Gln Asp Ala Leu Asn Gln Glu Thr Thr Tyr Val 
        195                 200                 205             


Ser Asn Leu Thr Arg Ser Met Ser Leu Val Leu Asp Glu Phe Tyr Ser 
    210                 215                 220                 


Ser Leu Arg Val Val Gly Val Ser Ala Val Leu Gly Thr Gly Leu Asp 
225                 230                 235                 240 


Glu Leu Phe Val Gln Val Thr Ser Ala Ala Glu Glu Tyr Glu Arg Glu 
                245                 250                 255     


Tyr Arg Pro Glu Tyr Glu Arg Leu Lys Lys Ser Leu Ala Asn Ala Glu 
            260                 265                 270         


Ser Gln Gln Gln Arg Glu Gln Leu Glu Arg Leu Arg Lys Asp Met Gly 
        275                 280                 285             


Ser Val Ala Leu Asp Ala Gly Thr Ala Lys Asp Ser Leu Ser Pro Val 
    290                 295                 300                 


Leu His Pro Ser Asp Leu Ile Leu Thr Arg Gly Thr Leu Asp Glu Glu 
305                 310                 315                 320 


Asp Glu Glu Ala Asp Ser Asp Thr Asp Asp Ile Asp His Arg Val Thr 
                325                 330                 335     


Glu Glu Ser His Glu Glu Pro Ala Phe Gln Asn Phe Met Gln Glu Ser 
            340                 345                 350         


Met Ala Gln Tyr Trp Lys Arg Asn Asn Lys 
        355                 360         


<210>  4631
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPNMB__Homo_sapiens__NP_001005340

<400>  4631

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Ala Thr Thr Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly 
            340                 345                 350         


Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn 
        355                 360                 365             


Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr Ile Thr Ile Val 
    370                 375                 380                 


Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr Asp Val Leu Met 
385                 390                 395                 400 


Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe Val Val Thr Cys 
                405                 410                 415     


Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile Ser Asp Pro Thr 
            420                 425                 430         


Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val Asp Val Asp Glu 
        435                 440                 445             


Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr 
    450                 455                 460                 


Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser Pro Leu Arg Met 
                485                 490                 495     


Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala Ile Phe Val Thr 
            500                 505                 510         


Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu Tyr Asn Pro Ile 
        515                 520                 525             


Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly Leu Ser Val Phe 
    530                 535                 540                 


Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn Gln Glu Lys Asp 
545                 550                 555                 560 


Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
                565                 570         


<210>  4632
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR101__Homo_sapiens__NP_473362

<400>  4632

Met Thr Ser Thr Cys Thr Asn Ser Thr Arg Glu Ser Asn Ser Ser His 
1               5                   10                  15      


Thr Cys Met Pro Leu Ser Lys Met Pro Ile Ser Leu Ala His Gly Ile 
            20                  25                  30          


Ile Arg Ser Thr Val Leu Val Ile Phe Leu Ala Ala Ser Phe Val Gly 
        35                  40                  45              


Asn Ile Val Leu Ala Leu Val Leu Gln Arg Lys Pro Gln Leu Leu Gln 
    50                  55                  60                  


Val Thr Asn Arg Phe Ile Phe Asn Leu Leu Val Thr Asp Leu Leu Gln 
65                  70                  75                  80  


Ile Ser Leu Val Ala Pro Trp Val Val Ala Thr Ser Val Pro Leu Phe 
                85                  90                  95      


Trp Pro Leu Asn Ser His Phe Cys Thr Ala Leu Val Ser Leu Thr His 
            100                 105                 110         


Leu Phe Ala Phe Ala Ser Val Asn Thr Ile Val Val Val Ser Val Asp 
        115                 120                 125             


Arg Tyr Leu Ser Ile Ile His Pro Leu Ser Tyr Pro Ser Lys Met Thr 
    130                 135                 140                 


Gln Arg Arg Gly Tyr Leu Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile 
145                 150                 155                 160 


Leu Gln Ser Thr Pro Pro Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp 
                165                 170                 175     


Glu Arg Asn Ala Leu Cys Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr 
            180                 185                 190         


Thr Ile Leu Ser Val Val Ser Phe Ile Val Ile Pro Leu Ile Val Met 
        195                 200                 205             


Ile Ala Cys Tyr Ser Val Val Phe Cys Ala Ala Arg Arg Gln His Ala 
    210                 215                 220                 


Leu Leu Tyr Asn Val Lys Arg His Ser Leu Glu Val Arg Val Lys Asp 
225                 230                 235                 240 


Cys Val Glu Asn Glu Asp Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe 
                245                 250                 255     


Gln Asp Glu Ser Glu Phe Arg Arg Gln His Glu Gly Glu Val Lys Ala 
            260                 265                 270         


Lys Glu Gly Arg Met Glu Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu 
        275                 280                 285             


Gly Ser Thr Gly Thr Ser Glu Ser Ser Val Glu Ala Arg Gly Ser Glu 
    290                 295                 300                 


Glu Val Arg Glu Ser Ser Thr Val Ala Ser Asp Gly Ser Met Glu Gly 
305                 310                 315                 320 


Lys Glu Gly Ser Thr Lys Val Glu Glu Asn Ser Met Lys Ala Asp Lys 
                325                 330                 335     


Gly Arg Thr Glu Val Asn Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp 
            340                 345                 350         


Met Glu Phe Gly Glu Asp Asp Ile Asn Phe Ser Glu Asp Asp Val Glu 
        355                 360                 365             


Ala Val Asn Ile Pro Glu Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn 
    370                 375                 380                 


Ser Asn Pro Pro Leu Pro Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val 
385                 390                 395                 400 


Ile Phe Ile Ile Ile Phe Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys 
                405                 410                 415     


Phe Leu Ala Val Leu Ala Val Trp Val Asp Val Glu Thr Gln Val Pro 
            420                 425                 430         


Gln Trp Val Ile Thr Ile Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys 
        435                 440                 445             


Ile His Pro Tyr Val Tyr Gly Tyr Met His Lys Thr Ile Lys Lys Glu 
    450                 455                 460                 


Ile Gln Asp Met Leu Lys Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys 
465                 470                 475                 480 


Glu Asp Ser His Pro Asp Leu Pro Gly Thr Glu Gly Gly Thr Glu Gly 
                485                 490                 495     


Lys Ile Val Pro Ser Tyr Asp Ser Ala Thr Phe Pro 
            500                 505             


<210>  4633
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR119__Homo_sapiens__NP_848566

<400>  4633

Met Glu Ser Ser Phe Ser Phe Gly Val Ile Leu Ala Val Leu Ala Ser 
1               5                   10                  15      


Leu Ile Ile Ala Thr Asn Thr Leu Val Ala Val Ala Val Leu Leu Leu 
            20                  25                  30          


Ile His Lys Asn Asp Gly Val Ser Leu Cys Phe Thr Leu Asn Leu Ala 
        35                  40                  45              


Val Ala Asp Thr Leu Ile Gly Val Ala Ile Ser Gly Leu Leu Thr Asp 
    50                  55                  60                  


Gln Leu Ser Ser Pro Ser Arg Pro Thr Gln Lys Thr Leu Cys Ser Leu 
65                  70                  75                  80  


Arg Met Ala Phe Val Thr Ser Ser Ala Ala Ala Ser Val Leu Thr Val 
                85                  90                  95      


Met Leu Ile Thr Phe Asp Arg Tyr Leu Ala Ile Lys Gln Pro Phe Arg 
            100                 105                 110         


Tyr Leu Lys Ile Met Ser Gly Phe Val Ala Gly Ala Cys Ile Ala Gly 
        115                 120                 125             


Leu Trp Leu Val Ser Tyr Leu Ile Gly Phe Leu Pro Leu Gly Ile Pro 
    130                 135                 140                 


Met Phe Gln Gln Thr Ala Tyr Lys Gly Gln Cys Ser Phe Phe Ala Val 
145                 150                 155                 160 


Phe His Pro His Phe Val Leu Thr Leu Ser Cys Val Gly Phe Phe Pro 
                165                 170                 175     


Ala Met Leu Leu Phe Val Phe Phe Tyr Cys Asp Met Leu Lys Ile Ala 
            180                 185                 190         


Ser Met His Ser Gln Gln Ile Arg Lys Met Glu His Ala Gly Ala Met 
        195                 200                 205             


Ala Gly Gly Tyr Arg Ser Pro Arg Thr Pro Ser Asp Phe Lys Ala Leu 
    210                 215                 220                 


Arg Thr Val Ser Val Leu Ile Gly Ser Phe Ala Leu Ser Trp Thr Pro 
225                 230                 235                 240 


Phe Leu Ile Thr Gly Ile Val Gln Val Ala Cys Gln Glu Cys His Leu 
                245                 250                 255     


Tyr Leu Val Leu Glu Arg Tyr Leu Trp Leu Leu Gly Val Gly Asn Ser 
            260                 265                 270         


Leu Leu Asn Pro Leu Ile Tyr Ala Tyr Trp Gln Lys Glu Val Arg Leu 
        275                 280                 285             


Gln Leu Tyr His Met Ala Leu Gly Val Lys Lys Val Leu Thr Ser Phe 
    290                 295                 300                 


Leu Leu Phe Leu Ser Ala Arg Asn Cys Gly Pro Glu Arg Pro Arg Glu 
305                 310                 315                 320 


Ser Ser Cys His Ile Val Thr Ile Ser Ser Ser Glu Phe Asp Gly 
                325                 330                 335 


<210>  4634
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR12__Homo_sapiens__NP_005279

<400>  4634

Met Asn Glu Asp Leu Lys Val Asn Leu Ser Gly Leu Pro Arg Asp Tyr 
1               5                   10                  15      


Leu Asp Ala Ala Ala Ala Glu Asn Ile Ser Ala Ala Val Ser Ser Arg 
            20                  25                  30          


Val Pro Ala Val Glu Pro Glu Pro Glu Leu Val Val Asn Pro Trp Asp 
        35                  40                  45              


Ile Val Leu Cys Thr Ser Gly Thr Leu Ile Ser Cys Glu Asn Ala Ile 
    50                  55                  60                  


Val Val Leu Ile Ile Phe His Asn Pro Ser Leu Arg Ala Pro Met Phe 
65                  70                  75                  80  


Leu Leu Ile Gly Ser Leu Ala Leu Ala Asp Leu Leu Ala Gly Ile Gly 
                85                  90                  95      


Leu Ile Thr Asn Phe Val Phe Ala Tyr Leu Leu Gln Ser Glu Ala Thr 
            100                 105                 110         


Lys Leu Val Thr Ile Gly Leu Ile Val Ala Ser Phe Ser Ala Ser Val 
        115                 120                 125             


Cys Ser Leu Leu Ala Ile Thr Val Asp Arg Tyr Leu Ser Leu Tyr Tyr 
    130                 135                 140                 


Ala Leu Thr Tyr His Ser Glu Arg Thr Val Thr Phe Thr Tyr Val Met 
145                 150                 155                 160 


Leu Val Met Leu Trp Gly Thr Ser Ile Cys Leu Gly Leu Leu Pro Val 
                165                 170                 175     


Met Gly Trp Asn Cys Leu Arg Asp Glu Ser Thr Cys Ser Val Val Arg 
            180                 185                 190         


Pro Leu Thr Lys Asn Asn Ala Ala Ile Leu Ser Val Ser Phe Leu Phe 
        195                 200                 205             


Met Phe Ala Leu Met Leu Gln Leu Tyr Ile Gln Ile Cys Lys Ile Val 
    210                 215                 220                 


Met Arg His Ala His Gln Ile Ala Leu Gln His His Phe Leu Ala Thr 
225                 230                 235                 240 


Ser His Tyr Val Thr Thr Arg Lys Gly Val Ser Thr Leu Ala Ile Ile 
                245                 250                 255     


Leu Gly Thr Phe Ala Ala Cys Trp Met Pro Phe Thr Leu Tyr Ser Leu 
            260                 265                 270         


Ile Ala Asp Tyr Thr Tyr Pro Ser Ile Tyr Thr Tyr Ala Thr Leu Leu 
        275                 280                 285             


Pro Ala Thr Tyr Asn Ser Ile Ile Asn Pro Val Ile Tyr Ala Phe Arg 
    290                 295                 300                 


Asn Gln Glu Ile Gln Lys Ala Leu Cys Leu Ile Cys Cys Gly Cys Ile 
305                 310                 315                 320 


Pro Ser Ser Leu Ala Gln Arg Ala Arg Ser Pro Ser Asp Val 
                325                 330                 


<210>  4635
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR132__Homo_sapiens__NP_001265623

<400>  4635

Met Cys Pro Met Leu Leu Lys Asn Gly Tyr Asn Gly Asn Ala Thr Pro 
1               5                   10                  15      


Val Thr Thr Thr Ala Pro Trp Ala Ser Leu Gly Leu Ser Ala Lys Thr 
            20                  25                  30          


Cys Asn Asn Val Ser Phe Glu Glu Ser Arg Ile Val Leu Val Val Val 
        35                  40                  45              


Tyr Ser Ala Val Cys Thr Leu Gly Val Pro Ala Asn Cys Leu Thr Ala 
    50                  55                  60                  


Trp Leu Ala Leu Leu Gln Val Leu Gln Gly Asn Val Leu Ala Val Tyr 
65                  70                  75                  80  


Leu Leu Cys Leu Ala Leu Cys Glu Leu Leu Tyr Thr Gly Thr Leu Pro 
                85                  90                  95      


Leu Trp Val Ile Tyr Ile Arg Asn Gln His Arg Trp Thr Leu Gly Leu 
            100                 105                 110         


Leu Ala Cys Lys Val Thr Ala Tyr Ile Phe Phe Cys Asn Ile Tyr Val 
        115                 120                 125             


Ser Ile Leu Phe Leu Cys Cys Ile Ser Cys Asp Arg Phe Val Ala Val 
    130                 135                 140                 


Val Tyr Ala Leu Glu Ser Arg Gly Arg Arg Arg Arg Arg Thr Ala Ile 
145                 150                 155                 160 


Leu Ile Ser Ala Cys Ile Phe Ile Leu Val Gly Ile Val His Tyr Pro 
                165                 170                 175     


Val Phe Gln Thr Glu Asp Lys Glu Thr Cys Phe Asp Met Leu Gln Met 
            180                 185                 190         


Asp Ser Arg Ile Ala Gly Tyr Tyr Tyr Ala Arg Phe Thr Val Gly Phe 
        195                 200                 205             


Ala Ile Pro Leu Ser Ile Ile Ala Phe Thr Asn His Arg Ile Phe Arg 
    210                 215                 220                 


Ser Ile Lys Gln Ser Met Gly Leu Ser Ala Ala Gln Lys Ala Lys Val 
225                 230                 235                 240 


Lys His Ser Ala Ile Ala Val Val Val Ile Phe Leu Val Cys Phe Ala 
                245                 250                 255     


Pro Tyr His Leu Val Leu Leu Val Lys Ala Ala Ala Phe Ser Tyr Tyr 
            260                 265                 270         


Arg Gly Asp Arg Asn Ala Met Cys Gly Leu Glu Glu Arg Leu Tyr Thr 
        275                 280                 285             


Ala Ser Val Val Phe Leu Cys Leu Ser Thr Val Asn Gly Val Ala Asp 
    290                 295                 300                 


Pro Ile Ile Tyr Val Leu Ala Thr Asp His Ser Arg Gln Glu Val Ser 
305                 310                 315                 320 


Arg Ile His Lys Gly Trp Lys Glu Trp Ser Met Lys Thr Asp Val Thr 
                325                 330                 335     


Arg Leu Thr His Ser Arg Asp Thr Glu Glu Leu Gln Ser Pro Val Ala 
            340                 345                 350         


Leu Ala Asp His Tyr Thr Phe Ser Arg Pro Val His Pro Pro Gly Ser 
        355                 360                 365             


Pro Cys Pro Ala Lys Arg Leu Ile Glu Glu Ser Cys 
    370                 375                 380 


<210>  4636
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR135__Homo_sapiens__NP_072093

<400>  4636

Met Glu Glu Pro Gln Pro Pro Arg Pro Pro Ala Ser Met Ala Leu Leu 
1               5                   10                  15      


Gly Ser Gln His Ser Gly Ala Pro Ser Ala Ala Gly Pro Pro Gly Gly 
            20                  25                  30          


Thr Ser Ser Ala Ala Thr Ala Ala Val Leu Ser Phe Ser Thr Val Ala 
        35                  40                  45              


Thr Ala Ala Leu Gly Asn Leu Ser Asp Ala Ser Gly Gly Gly Thr Ala 
    50                  55                  60                  


Ala Ala Pro Gly Gly Gly Gly Leu Gly Gly Ser Gly Ala Ala Arg Glu 
65                  70                  75                  80  


Ala Gly Ala Ala Val Arg Arg Pro Leu Gly Pro Glu Ala Ala Pro Leu 
                85                  90                  95      


Leu Ser His Gly Ala Ala Val Ala Ala Gln Ala Leu Val Leu Leu Leu 
            100                 105                 110         


Ile Phe Leu Leu Ser Ser Leu Gly Asn Cys Ala Val Met Gly Val Ile 
        115                 120                 125             


Val Lys His Arg Gln Leu Arg Thr Val Thr Asn Ala Phe Ile Leu Ser 
    130                 135                 140                 


Leu Ser Leu Ser Asp Leu Leu Thr Ala Leu Leu Cys Leu Pro Ala Ala 
145                 150                 155                 160 


Phe Leu Asp Leu Phe Thr Pro Pro Gly Gly Ser Ala Pro Ala Ala Ala 
                165                 170                 175     


Ala Gly Pro Trp Arg Gly Phe Cys Ala Ala Ser Arg Phe Phe Ser Ser 
            180                 185                 190         


Cys Phe Gly Ile Val Ser Thr Leu Ser Val Ala Leu Ile Ser Leu Asp 
        195                 200                 205             


Arg Tyr Cys Ala Ile Val Arg Pro Pro Arg Glu Lys Ile Gly Arg Arg 
    210                 215                 220                 


Arg Ala Leu Gln Leu Leu Ala Gly Ala Trp Leu Thr Ala Leu Gly Phe 
225                 230                 235                 240 


Ser Leu Pro Trp Glu Leu Leu Gly Ala Pro Arg Glu Leu Ala Ala Ala 
                245                 250                 255     


Gln Ser Phe His Gly Cys Leu Tyr Arg Thr Ser Pro Asp Pro Ala Gln 
            260                 265                 270         


Leu Gly Ala Ala Phe Ser Val Gly Leu Val Val Ala Cys Tyr Leu Leu 
        275                 280                 285             


Pro Phe Leu Leu Met Cys Phe Cys His Tyr His Ile Cys Lys Thr Val 
    290                 295                 300                 


Arg Leu Ser Asp Val Arg Val Arg Pro Val Asn Thr Tyr Ala Arg Val 
305                 310                 315                 320 


Leu Arg Phe Phe Ser Glu Val Arg Thr Ala Thr Thr Val Leu Ile Met 
                325                 330                 335     


Ile Val Phe Val Ile Cys Cys Trp Gly Pro Tyr Cys Phe Leu Val Leu 
            340                 345                 350         


Leu Ala Ala Ala Arg Gln Ala Gln Thr Met Gln Ala Pro Ser Leu Leu 
        355                 360                 365             


Ser Val Val Ala Val Trp Leu Thr Trp Ala Asn Gly Ala Ile Asn Pro 
    370                 375                 380                 


Val Ile Tyr Ala Ile Arg Asn Pro Asn Ile Ser Met Leu Leu Gly Arg 
385                 390                 395                 400 


Asn Arg Glu Glu Gly Tyr Arg Thr Arg Asn Val Asp Ala Phe Leu Pro 
                405                 410                 415     


Ser Gln Gly Pro Gly Leu Gln Ala Arg Ser Arg Ser Arg Leu Arg Asn 
            420                 425                 430         


Arg Tyr Ala Asn Arg Leu Gly Ala Cys Asn Arg Met Ser Ser Ser Asn 
        435                 440                 445             


Pro Ala Ser Gly Val Ala Gly Asp Val Ala Met Trp Ala Arg Lys Asn 
    450                 455                 460                 


Pro Val Val Leu Phe Cys Arg Glu Gly Pro Pro Glu Pro Val Thr Ala 
465                 470                 475                 480 


Val Thr Lys Gln Pro Lys Ser Glu Ala Gly Asp Thr Ser Leu 
                485                 490                 


<210>  4637
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR137C__Homo_sapiens__NP_001093122

<400>  4637

Met Arg Val Ser Val Pro Gly Pro Ala Ala Ala Ala Ala Pro Ala Ala 
1               5                   10                  15      


Gly Arg Glu Pro Ser Thr Pro Gly Gly Gly Ser Gly Gly Gly Gly Ala 
            20                  25                  30          


Val Ala Ala Ala Ser Gly Ala Ala Val Pro Gly Ser Val Gln Leu Ala 
        35                  40                  45              


Leu Ser Val Leu His Ala Leu Leu Tyr Ala Ala Leu Phe Ala Phe Ala 
    50                  55                  60                  


Tyr Leu Gln Leu Trp Arg Leu Leu Leu Tyr Arg Glu Arg Arg Leu Ser 
65                  70                  75                  80  


Tyr Gln Ser Leu Cys Leu Phe Leu Cys Leu Leu Trp Ala Ala Leu Arg 
                85                  90                  95      


Thr Thr Leu Phe Ser Ala Ala Phe Ser Leu Ser Gly Ser Leu Pro Leu 
            100                 105                 110         


Leu Arg Pro Pro Ala His Leu His Phe Phe Pro His Trp Leu Leu Tyr 
        115                 120                 125             


Cys Phe Pro Ser Cys Leu Gln Phe Ser Thr Leu Cys Leu Leu Asn Leu 
    130                 135                 140                 


Tyr Leu Ala Glu Val Ile Cys Lys Val Arg Cys Ala Thr Glu Leu Asp 
145                 150                 155                 160 


Arg His Lys Ile Leu Leu His Leu Gly Phe Ile Met Ala Ser Leu Leu 
                165                 170                 175     


Phe Leu Val Val Asn Leu Thr Cys Ala Met Leu Val His Gly Asp Val 
            180                 185                 190         


Pro Glu Asn Gln Leu Lys Trp Thr Val Phe Val Arg Ala Leu Ile Asn 
        195                 200                 205             


Asp Ser Leu Phe Ile Leu Cys Ala Ile Ser Leu Val Cys Tyr Ile Cys 
    210                 215                 220                 


Lys Ile Thr Lys Met Ser Ser Ala Asn Val Tyr Leu Glu Ser Lys Gly 
225                 230                 235                 240 


Met Ser Leu Cys Gln Thr Val Val Val Gly Ser Val Val Ile Leu Leu 
                245                 250                 255     


Tyr Ser Ser Arg Ala Cys Tyr Asn Leu Val Val Val Thr Ile Ser Gln 
            260                 265                 270         


Asp Thr Leu Glu Ser Pro Phe Asn Tyr Gly Trp Asp Asn Leu Ser Asp 
        275                 280                 285             


Lys Ala His Val Glu Asp Ile Ser Gly Glu Glu Tyr Ile Val Phe Gly 
    290                 295                 300                 


Met Val Leu Phe Leu Trp Glu His Val Pro Ala Trp Ser Val Val Leu 
305                 310                 315                 320 


Phe Phe Arg Ala Gln Arg Leu Asn Gln Asn Leu Ala Pro Ala Gly Met 
                325                 330                 335     


Ile Asn Ser His Ser Tyr Ser Ser Arg Ala Tyr Phe Phe Asp Asn Pro 
            340                 345                 350         


Arg Arg Tyr Asp Ser Asp Asp Asp Leu Pro Arg Leu Gly Ser Ser Arg 
        355                 360                 365             


Glu Gly Ser Leu Pro Asn Ser Gln Ser Leu Gly Trp Tyr Gly Thr Met 
    370                 375                 380                 


Thr Gly Cys Gly Ser Ser Ser Tyr Thr Val Thr Pro His Leu Asn Gly 
385                 390                 395                 400 


Pro Met Thr Asp Thr Ala Pro Leu Leu Phe Thr Cys Ser Asn Leu Asp 
                405                 410                 415     


Leu Asn Asn His His Ser Leu Tyr Val Thr Pro Gln Asn 
            420                 425                 


<210>  4638
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR139__Homo_sapiens__NP_001002911

<400>  4638

Met Glu His Thr His Ala His Leu Ala Ala Asn Ser Ser Leu Ser Trp 
1               5                   10                  15      


Trp Ser Pro Gly Ser Ala Cys Gly Leu Gly Phe Val Pro Val Val Tyr 
            20                  25                  30          


Tyr Ser Leu Leu Leu Cys Leu Gly Leu Pro Ala Asn Ile Leu Thr Val 
        35                  40                  45              


Ile Ile Leu Ser Gln Leu Val Ala Arg Arg Gln Lys Ser Ser Tyr Asn 
    50                  55                  60                  


Tyr Leu Leu Ala Leu Ala Ala Ala Asp Ile Leu Val Leu Phe Phe Ile 
65                  70                  75                  80  


Val Phe Val Asp Phe Leu Leu Glu Asp Phe Ile Leu Asn Met Gln Met 
                85                  90                  95      


Pro Gln Val Pro Asp Lys Ile Ile Glu Val Leu Glu Phe Ser Ser Ile 
            100                 105                 110         


His Thr Ser Ile Trp Ile Thr Val Pro Leu Thr Ile Asp Arg Tyr Ile 
        115                 120                 125             


Ala Val Cys His Pro Leu Lys Tyr His Thr Val Ser Tyr Pro Ala Arg 
    130                 135                 140                 


Thr Arg Lys Val Ile Val Ser Val Tyr Ile Thr Cys Phe Leu Thr Ser 
145                 150                 155                 160 


Ile Pro Tyr Tyr Trp Trp Pro Asn Ile Trp Thr Glu Asp Tyr Ile Ser 
                165                 170                 175     


Thr Ser Val His His Val Leu Ile Trp Ile His Cys Phe Thr Val Tyr 
            180                 185                 190         


Leu Val Pro Cys Ser Ile Phe Phe Ile Leu Asn Ser Ile Ile Val Tyr 
        195                 200                 205             


Lys Leu Arg Arg Lys Ser Asn Phe Arg Leu Arg Gly Tyr Ser Thr Gly 
    210                 215                 220                 


Lys Thr Thr Ala Ile Leu Phe Thr Ile Thr Ser Ile Phe Ala Thr Leu 
225                 230                 235                 240 


Trp Ala Pro Arg Ile Ile Met Ile Leu Tyr His Leu Tyr Gly Ala Pro 
                245                 250                 255     


Ile Gln Asn Arg Trp Leu Val His Ile Met Ser Asp Ile Ala Asn Met 
            260                 265                 270         


Leu Ala Leu Leu Asn Thr Ala Ile Asn Phe Phe Leu Tyr Cys Phe Ile 
        275                 280                 285             


Ser Lys Arg Phe Arg Thr Met Ala Ala Ala Thr Leu Lys Ala Phe Phe 
    290                 295                 300                 


Lys Cys Gln Lys Gln Pro Val Gln Phe Tyr Thr Asn His Asn Phe Ser 
305                 310                 315                 320 


Ile Thr Ser Ser Pro Trp Ile Ser Pro Ala Asn Ser His Cys Ile Lys 
                325                 330                 335     


Met Leu Val Tyr Gln Tyr Asp Lys Asn Gly Lys Pro Ile Lys Val Ser 
            340                 345                 350         


Pro 
    


<210>  4639
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR143__Homo_sapiens__NP_000264

<400>  4639

Met Ala Ser Pro Arg Leu Gly Thr Phe Cys Cys Pro Thr Arg Asp Ala 
1               5                   10                  15      


Ala Thr Gln Leu Val Leu Ser Phe Gln Pro Arg Ala Phe His Ala Leu 
            20                  25                  30          


Cys Leu Gly Ser Gly Gly Leu Arg Leu Ala Leu Gly Leu Leu Gln Leu 
        35                  40                  45              


Leu Pro Gly Arg Arg Pro Ala Gly Pro Gly Ser Pro Ala Thr Ser Pro 
    50                  55                  60                  


Pro Ala Ser Val Arg Ile Leu Arg Ala Ala Ala Ala Cys Asp Leu Leu 
65                  70                  75                  80  


Gly Cys Leu Gly Met Val Ile Arg Ser Thr Val Trp Leu Gly Phe Pro 
                85                  90                  95      


Asn Phe Val Asp Ser Val Ser Asp Met Asn His Thr Glu Ile Trp Pro 
            100                 105                 110         


Ala Ala Phe Cys Val Gly Ser Ala Met Trp Ile Gln Leu Leu Tyr Ser 
        115                 120                 125             


Ala Cys Phe Trp Trp Leu Phe Cys Tyr Ala Val Asp Ala Tyr Leu Val 
    130                 135                 140                 


Ile Arg Arg Ser Ala Gly Leu Ser Thr Ile Leu Leu Tyr His Ile Met 
145                 150                 155                 160 


Ala Trp Gly Leu Ala Thr Leu Leu Cys Val Glu Gly Ala Ala Met Leu 
                165                 170                 175     


Tyr Tyr Pro Ser Val Ser Arg Cys Glu Arg Gly Leu Asp His Ala Ile 
            180                 185                 190         


Pro His Tyr Val Thr Met Tyr Leu Pro Leu Leu Leu Val Leu Val Ala 
        195                 200                 205             


Asn Pro Ile Leu Phe Gln Lys Thr Val Thr Ala Val Ala Ser Leu Leu 
    210                 215                 220                 


Lys Gly Arg Gln Gly Ile Tyr Thr Glu Asn Glu Arg Arg Met Gly Ala 
225                 230                 235                 240 


Val Ile Lys Ile Arg Phe Phe Lys Ile Met Leu Val Leu Ile Ile Cys 
                245                 250                 255     


Trp Leu Ser Asn Ile Ile Asn Glu Ser Leu Leu Phe Tyr Leu Glu Met 
            260                 265                 270         


Gln Thr Asp Ile Asn Gly Gly Ser Leu Lys Pro Val Arg Thr Ala Ala 
        275                 280                 285             


Lys Thr Thr Trp Phe Ile Met Gly Ile Leu Asn Pro Ala Gln Gly Phe 
    290                 295                 300                 


Leu Leu Ser Leu Ala Phe Tyr Gly Trp Thr Gly Cys Ser Leu Gly Phe 
305                 310                 315                 320 


Gln Ser Pro Arg Lys Glu Ile Gln Trp Glu Ser Leu Thr Thr Ser Ala 
                325                 330                 335     


Ala Glu Gly Ala His Pro Ser Pro Leu Met Pro His Glu Asn Pro Ala 
            340                 345                 350         


Ser Gly Lys Val Ser Gln Val Gly Gly Gln Thr Ser Asp Glu Ala Leu 
        355                 360                 365             


Ser Met Leu Ser Glu Gly Ser Asp Ala Ser Thr Ile Glu Ile His Thr 
    370                 375                 380                 


Ala Ser Glu Ser Cys Asn Lys Asn Glu Gly Asp Pro Ala Leu Pro Thr 
385                 390                 395                 400 


His Gly Asp Leu 
                


<210>  4640
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR148__Homo_sapiens__NP_997247

<400>  4640

Met Gly Asp Glu Leu Ala Pro Cys Pro Val Gly Thr Thr Ala Trp Pro 
1               5                   10                  15      


Ala Leu Ile Gln Leu Ile Ser Lys Thr Pro Cys Met Pro Gln Ala Ala 
            20                  25                  30          


Ser Asn Thr Ser Leu Gly Leu Gly Asp Leu Arg Val Pro Ser Ser Met 
        35                  40                  45              


Leu Tyr Trp Leu Phe Leu Pro Ser Ser Leu Leu Ala Ala Ala Thr Leu 
    50                  55                  60                  


Ala Val Ser Pro Leu Leu Leu Val Thr Ile Leu Arg Asn Gln Arg Leu 
65                  70                  75                  80  


Arg Gln Glu Pro His Tyr Leu Leu Pro Ala Asn Ile Leu Leu Ser Asp 
                85                  90                  95      


Leu Ala Tyr Ile Leu Leu His Met Leu Ile Ser Ser Ser Ser Leu Gly 
            100                 105                 110         


Gly Trp Glu Leu Gly Arg Met Ala Cys Gly Ile Leu Thr Asp Ala Val 
        115                 120                 125             


Phe Ala Ala Cys Thr Ser Thr Ile Leu Ser Phe Thr Ala Ile Val Leu 
    130                 135                 140                 


His Thr Tyr Leu Ala Val Ile His Pro Leu Arg Tyr Leu Ser Phe Met 
145                 150                 155                 160 


Ser His Gly Ala Ala Trp Lys Ala Val Ala Leu Ile Trp Leu Val Ala 
                165                 170                 175     


Cys Cys Phe Pro Thr Phe Leu Ile Trp Leu Ser Lys Trp Gln Asp Ala 
            180                 185                 190         


Gln Leu Glu Glu Gln Gly Ala Ser Tyr Ile Leu Pro Pro Ser Met Gly 
        195                 200                 205             


Thr Gln Pro Gly Cys Gly Leu Leu Val Ile Val Thr Tyr Thr Ser Ile 
    210                 215                 220                 


Leu Cys Val Leu Phe Leu Cys Thr Ala Leu Ile Ala Asn Cys Phe Trp 
225                 230                 235                 240 


Arg Ile Tyr Ala Glu Ala Lys Thr Ser Gly Ile Trp Gly Gln Gly Tyr 
                245                 250                 255     


Ser Arg Ala Arg Gly Thr Leu Leu Ile His Ser Val Leu Ile Thr Leu 
            260                 265                 270         


Tyr Val Ser Thr Gly Val Val Phe Ser Leu Asp Met Val Leu Thr Arg 
        275                 280                 285             


Tyr His His Ile Asp Ser Gly Thr His Thr Trp Leu Leu Ala Ala Asn 
    290                 295                 300                 


Ser Glu Val Leu Met Met Leu Pro Arg Ala Met Leu Thr Tyr Leu Tyr 
305                 310                 315                 320 


Leu Leu Arg Tyr Arg Gln Leu Leu Gly Met Val Arg Gly His Leu Pro 
                325                 330                 335     


Ser Arg Arg His Gln Ala Ile Phe Thr Ile Ser 
            340                 345         


<210>  4641
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR149__Homo_sapiens__NP_001033794

<400>  4641

Met Ser Leu Phe Leu Ser Asn Leu Ser Thr Asn Asp Ser Ser Leu Trp 
1               5                   10                  15      


Lys Glu Asn His Asn Ser Thr Asp Leu Leu Asn Pro Pro Gly Thr Leu 
            20                  25                  30          


Asn Ile Tyr Leu Phe Cys Leu Thr Cys Leu Met Thr Phe Ala Ala Leu 
        35                  40                  45              


Val Gly Ser Ile Tyr Ser Leu Ile Ser Leu Leu Lys Met Gln Asn Arg 
    50                  55                  60                  


Thr Val Val Ser Met Leu Val Ala Ser Trp Ser Val Asp Asp Leu Met 
65                  70                  75                  80  


Ser Val Leu Ser Val Thr Ile Phe Met Phe Leu Gln Trp Pro Asn Glu 
                85                  90                  95      


Val Pro Gly Tyr Phe Gln Phe Leu Cys Thr Thr Ser Ala Leu Met Tyr 
            100                 105                 110         


Leu Cys Gln Gly Leu Ser Ser Asn Leu Lys Ala Thr Leu Leu Val Ser 
        115                 120                 125             


Tyr Asn Phe Tyr Thr Met His Arg Gly Val Gly Ser Gln Thr Ala Ser 
    130                 135                 140                 


Arg Arg Ser Gly Gln Val Leu Gly Val Val Leu Thr Val Trp Ala Ala 
145                 150                 155                 160 


Ser Leu Leu Leu Ser Ala Leu Pro Leu Cys Gly Trp Gly Ala Phe Val 
                165                 170                 175     


Arg Thr Pro Trp Gly Cys Leu Val Asp Cys Ser Ser Ser Tyr Val Leu 
            180                 185                 190         


Phe Leu Ser Ile Val Tyr Ala Leu Ala Phe Gly Leu Leu Val Gly Leu 
        195                 200                 205             


Ser Val Pro Leu Thr His Arg Leu Leu Cys Ser Glu Glu Pro Pro Arg 
    210                 215                 220                 


Leu His Ser Asn Tyr Gln Glu Ile Ser Arg Gly Ala Ser Ile Pro Gly 
225                 230                 235                 240 


Thr Pro Pro Thr Ala Gly Arg Val Val Ser Leu Ser Pro Glu Asp Ala 
                245                 250                 255     


Pro Gly Pro Ser Leu Arg Arg Ser Gly Gly Cys Ser Pro Ser Ser Asp 
            260                 265                 270         


Thr Val Phe Gly Pro Gly Ala Pro Ala Ala Ala Gly Ala Glu Ala Cys 
        275                 280                 285             


Arg Arg Glu Asn Arg Gly Thr Leu Tyr Gly Thr Arg Ser Phe Thr Val 
    290                 295                 300                 


Ser Val Ala Gln Lys Arg Phe Ala Leu Ile Leu Ala Leu Thr Lys Val 
305                 310                 315                 320 


Val Leu Trp Leu Pro Met Met Met His Met Val Val Gln Asn Val Val 
                325                 330                 335     


Gly Phe Gln Ser Leu Pro Leu Glu Thr Phe Ser Phe Leu Leu Thr Leu 
            340                 345                 350         


Leu Ala Thr Thr Val Thr Pro Val Phe Val Leu Ser Lys Arg Trp Thr 
        355                 360                 365             


His Leu Pro Cys Gly Cys Ile Ile Asn Cys Arg Gln Asn Ala Tyr Ala 
    370                 375                 380                 


Val Ala Ser Asp Gly Lys Lys Ile Lys Arg Lys Gly Phe Glu Phe Asn 
385                 390                 395                 400 


Leu Ser Phe Gln Lys Ser Tyr Gly Ile Tyr Lys Ile Ala His Glu Asp 
                405                 410                 415     


Tyr Tyr Asp Asp Asp Glu Asn Ser Ile Phe Tyr His Asn Leu Met Asn 
            420                 425                 430         


Ser Glu Cys Glu Thr Thr Lys Asp Pro Gln Arg Asp Asn Arg Asn Ile 
        435                 440                 445             


Phe Asn Ala Ile Lys Val Glu Ile Ser Thr Thr Pro Ser Leu Asp Ser 
    450                 455                 460                 


Ser Thr Gln Arg Gly Ile Asn Lys Cys Thr Asn Thr Asp Ile Thr Glu 
465                 470                 475                 480 


Ala Lys Gln Asp Ser Asn Asn Lys Lys Asp Ala Phe Ser Asp Lys Thr 
                485                 490                 495     


Gly Gly Asp Ile Asn Tyr Glu Glu Thr Thr Phe Ser Glu Gly Pro Glu 
            500                 505                 510         


Arg Arg Leu Ser His Glu Glu Ser Gln Lys Pro Asp Leu Ser Asp Trp 
        515                 520                 525             


Glu Trp Cys Arg Ser Lys Ser Glu Arg Thr Pro Arg Gln Arg Ser Gly 
    530                 535                 540                 


Tyr Ala Leu Ala Ile Pro Leu Cys Ala Phe Gln Gly Thr Val Ser Leu 
545                 550                 555                 560 


His Ala Pro Thr Gly Lys Thr Leu Ser Leu Ser Thr Tyr Glu Val Ser 
                565                 570                 575     


Ala Glu Gly Gln Lys Ile Thr Pro Ala Ser Lys Lys Ile Glu Val Tyr 
            580                 585                 590         


Arg Ser Lys Ser Val Gly His Glu Pro Asn Ser Glu Asp Ser Ser Ser 
        595                 600                 605             


Thr Phe Val Asp Thr Ser Val Lys Ile His Leu Glu Val Leu Glu Ile 
    610                 615                 620                 


Cys Asp Asn Glu Glu Ala Leu Asp Thr Val Ser Ile Ile Ser Asn Ile 
625                 630                 635                 640 


Ser Gln Ser Ser Thr Gln Val Arg Ser Pro Ser Leu Arg Tyr Ser Arg 
                645                 650                 655     


Lys Glu Asn Arg Phe Val Ser Cys Asp Leu Gly Glu Thr Ala Ser Tyr 
            660                 665                 670         


Ser Leu Phe Leu Pro Thr Ser Asn Pro Asp Gly Asp Ile Asn Ile Ser 
        675                 680                 685             


Ile Pro Asp Thr Val Glu Ala His Arg Gln Asn Ser Lys Arg Gln His 
    690                 695                 700                 


Gln Glu Arg Asp Gly Tyr Gln Glu Glu Ile Gln Leu Leu Asn Lys Ala 
705                 710                 715                 720 


Tyr Arg Lys Arg Glu Glu Glu Ser Lys Gly Ser 
                725                 730     


<210>  4642
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR150__Homo_sapiens__NP_954713

<400>  4642

Met Glu Asp Leu Phe Ser Pro Ser Ile Leu Pro Pro Ala Pro Asn Ile 
1               5                   10                  15      


Ser Val Pro Ile Leu Leu Gly Trp Gly Leu Asn Leu Thr Leu Gly Gln 
            20                  25                  30          


Gly Ala Pro Ala Ser Gly Pro Pro Ser Arg Arg Val Arg Leu Val Phe 
        35                  40                  45              


Leu Gly Val Ile Leu Val Val Ala Val Ala Gly Asn Thr Thr Val Leu 
    50                  55                  60                  


Cys Arg Leu Cys Gly Gly Gly Gly Pro Trp Ala Gly Pro Lys Arg Arg 
65                  70                  75                  80  


Lys Met Asp Phe Leu Leu Val Gln Leu Ala Leu Ala Asp Leu Tyr Ala 
                85                  90                  95      


Cys Gly Gly Thr Ala Leu Ser Gln Leu Ala Trp Glu Leu Leu Gly Glu 
            100                 105                 110         


Pro Arg Ala Ala Thr Gly Asp Leu Ala Cys Arg Phe Leu Gln Leu Leu 
        115                 120                 125             


Gln Ala Ser Gly Arg Gly Ala Ser Ala His Leu Val Val Leu Ile Ala 
    130                 135                 140                 


Leu Glu Arg Arg Arg Ala Val Arg Leu Pro His Gly Arg Pro Leu Pro 
145                 150                 155                 160 


Ala Arg Ala Leu Ala Ala Leu Gly Trp Leu Leu Ala Leu Leu Leu Ala 
                165                 170                 175     


Leu Pro Pro Ala Phe Val Val Arg Gly Asp Ser Pro Ser Pro Leu Pro 
            180                 185                 190         


Pro Pro Pro Pro Pro Thr Ser Leu Gln Pro Gly Ala Pro Pro Ala Ala 
        195                 200                 205             


Arg Ala Trp Pro Gly Glu Arg Arg Cys His Gly Ile Phe Ala Pro Leu 
    210                 215                 220                 


Pro Arg Trp His Leu Gln Val Tyr Ala Phe Tyr Glu Ala Val Ala Gly 
225                 230                 235                 240 


Phe Val Ala Pro Val Thr Val Leu Gly Val Ala Cys Gly His Leu Leu 
                245                 250                 255     


Ser Val Trp Trp Arg His Arg Pro Gln Ala Pro Ala Ala Ala Ala Pro 
            260                 265                 270         


Trp Ser Ala Ser Pro Gly Arg Ala Pro Ala Pro Ser Ala Leu Pro Arg 
        275                 280                 285             


Ala Lys Val Gln Ser Leu Lys Met Ser Leu Leu Leu Ala Leu Leu Phe 
    290                 295                 300                 


Val Gly Cys Glu Leu Pro Tyr Phe Ala Ala Arg Leu Ala Ala Ala Trp 
305                 310                 315                 320 


Ser Ser Gly Pro Ala Gly Asp Trp Glu Gly Glu Gly Leu Ser Ala Ala 
                325                 330                 335     


Leu Arg Val Val Ala Met Ala Asn Ser Ala Leu Asn Pro Phe Val Tyr 
            340                 345                 350         


Leu Phe Phe Gln Ala Gly Asp Cys Arg Leu Arg Arg Gln Leu Arg Lys 
        355                 360                 365             


Arg Leu Gly Ser Leu Cys Cys Ala Pro Gln Gly Gly Ala Glu Asp Glu 
    370                 375                 380                 


Glu Gly Pro Arg Gly His Gln Ala Leu Tyr Arg Gln Arg Trp Pro His 
385                 390                 395                 400 


Pro His Tyr His His Ala Arg Arg Glu Pro Leu Asp Glu Gly Gly Leu 
                405                 410                 415     


Arg Pro Pro Pro Pro Arg Pro Arg Pro Leu Pro Cys Ser Cys Glu Ser 
            420                 425                 430         


Ala Phe 
        


<210>  4643
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR151__Homo_sapiens__NP_919227

<400>  4643

Met Leu Ala Ala Ala Phe Ala Asp Ser Asn Ser Ser Ser Met Asn Val 
1               5                   10                  15      


Ser Phe Ala His Leu His Phe Ala Gly Gly Tyr Leu Pro Ser Asp Ser 
            20                  25                  30          


Gln Asp Trp Arg Thr Ile Ile Pro Ala Leu Leu Val Ala Val Cys Leu 
        35                  40                  45              


Val Gly Phe Val Gly Asn Leu Cys Val Ile Gly Ile Leu Leu His Asn 
    50                  55                  60                  


Ala Trp Lys Gly Lys Pro Ser Met Ile His Ser Leu Ile Leu Asn Leu 
65                  70                  75                  80  


Ser Leu Ala Asp Leu Ser Leu Leu Leu Phe Ser Ala Pro Ile Arg Ala 
                85                  90                  95      


Thr Ala Tyr Ser Lys Ser Val Trp Asp Leu Gly Trp Phe Val Cys Lys 
            100                 105                 110         


Ser Ser Asp Trp Phe Ile His Thr Cys Met Ala Ala Lys Ser Leu Thr 
        115                 120                 125             


Ile Val Val Val Ala Lys Val Cys Phe Met Tyr Ala Ser Asp Pro Ala 
    130                 135                 140                 


Lys Gln Val Ser Ile His Asn Tyr Thr Ile Trp Ser Val Leu Val Ala 
145                 150                 155                 160 


Ile Trp Thr Val Ala Ser Leu Leu Pro Leu Pro Glu Trp Phe Phe Ser 
                165                 170                 175     


Thr Ile Arg His His Glu Gly Val Glu Met Cys Leu Val Asp Val Pro 
            180                 185                 190         


Ala Val Ala Glu Glu Phe Met Ser Met Phe Gly Lys Leu Tyr Pro Leu 
        195                 200                 205             


Leu Ala Phe Gly Leu Pro Leu Phe Phe Ala Ser Phe Tyr Phe Trp Arg 
    210                 215                 220                 


Ala Tyr Asp Gln Cys Lys Lys Arg Gly Thr Lys Thr Gln Asn Leu Arg 
225                 230                 235                 240 


Asn Gln Ile Arg Ser Lys Gln Val Thr Val Met Leu Leu Ser Ile Ala 
                245                 250                 255     


Ile Ile Ser Ala Leu Leu Trp Leu Pro Glu Trp Val Ala Trp Leu Trp 
            260                 265                 270         


Val Trp His Leu Lys Ala Ala Gly Pro Ala Pro Pro Gln Gly Phe Ile 
        275                 280                 285             


Ala Leu Ser Gln Val Leu Met Phe Ser Ile Ser Ser Ala Asn Pro Leu 
    290                 295                 300                 


Ile Phe Leu Val Met Ser Glu Glu Phe Arg Glu Gly Leu Lys Gly Val 
305                 310                 315                 320 


Trp Lys Trp Met Ile Thr Lys Lys Pro Pro Thr Val Ser Glu Ser Gln 
                325                 330                 335     


Glu Thr Pro Ala Gly Asn Ser Glu Gly Leu Pro Asp Lys Val Pro Ser 
            340                 345                 350         


Pro Glu Ser Pro Ala Ser Ile Pro Glu Lys Glu Lys Pro Ser Ser Pro 
        355                 360                 365             


Ser Ser Gly Lys Gly Lys Thr Glu Lys Ala Glu Ile Pro Ile Leu Pro 
    370                 375                 380                 


Asp Val Glu Gln Phe Trp His Glu Arg Asp Thr Val Pro Ser Val Gln 
385                 390                 395                 400 


Asp Asn Asp Pro Ile Pro Trp Glu His Glu Asp Gln Glu Thr Gly Glu 
                405                 410                 415     


Gly Val Lys 
            


<210>  4644
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR152__Homo_sapiens__NP_996880

<400>  4644

Met Asp Thr Thr Met Glu Ala Asp Leu Gly Ala Thr Gly His Arg Pro 
1               5                   10                  15      


Arg Thr Glu Leu Asp Asp Glu Asp Ser Tyr Pro Gln Gly Gly Trp Asp 
            20                  25                  30          


Thr Val Phe Leu Val Ala Leu Leu Leu Leu Gly Leu Pro Ala Asn Gly 
        35                  40                  45              


Leu Met Ala Trp Leu Ala Gly Ser Gln Ala Arg His Gly Ala Gly Thr 
    50                  55                  60                  


Arg Leu Ala Leu Leu Leu Leu Ser Leu Ala Leu Ser Asp Phe Leu Phe 
65                  70                  75                  80  


Leu Ala Ala Ala Ala Phe Gln Ile Leu Glu Ile Arg His Gly Gly His 
                85                  90                  95      


Trp Pro Leu Gly Thr Ala Ala Cys Arg Phe Tyr Tyr Phe Leu Trp Gly 
            100                 105                 110         


Val Ser Tyr Ser Ser Gly Leu Phe Leu Leu Ala Ala Leu Ser Leu Asp 
        115                 120                 125             


Arg Cys Leu Leu Ala Leu Cys Pro His Trp Tyr Pro Gly His Arg Pro 
    130                 135                 140                 


Val Arg Leu Pro Leu Trp Val Cys Ala Gly Val Trp Val Leu Ala Thr 
145                 150                 155                 160 


Leu Phe Ser Val Pro Trp Leu Val Phe Pro Glu Ala Ala Val Trp Trp 
                165                 170                 175     


Tyr Asp Leu Val Ile Cys Leu Asp Phe Trp Asp Ser Glu Glu Leu Ser 
            180                 185                 190         


Leu Arg Met Leu Glu Val Leu Gly Gly Phe Leu Pro Phe Leu Leu Leu 
        195                 200                 205             


Leu Val Cys His Val Leu Thr Gln Ala Thr Ala Cys Arg Thr Cys His 
    210                 215                 220                 


Arg Gln Gln Gln Pro Ala Ala Cys Arg Gly Phe Ala Arg Val Ala Arg 
225                 230                 235                 240 


Thr Ile Leu Ser Ala Tyr Val Val Leu Arg Leu Pro Tyr Gln Leu Ala 
                245                 250                 255     


Gln Leu Leu Tyr Leu Ala Phe Leu Trp Asp Val Tyr Ser Gly Tyr Leu 
            260                 265                 270         


Leu Trp Glu Ala Leu Val Tyr Ser Asp Tyr Leu Ile Leu Leu Asn Ser 
        275                 280                 285             


Cys Leu Ser Pro Phe Leu Cys Leu Met Ala Ser Ala Asp Leu Arg Thr 
    290                 295                 300                 


Leu Leu Arg Ser Val Leu Ser Ser Phe Ala Ala Ala Leu Cys Glu Glu 
305                 310                 315                 320 


Arg Pro Gly Ser Phe Thr Pro Thr Glu Pro Gln Thr Gln Leu Asp Ser 
                325                 330                 335     


Glu Gly Pro Thr Leu Pro Glu Pro Met Ala Glu Ala Gln Ser Gln Met 
            340                 345                 350         


Asp Pro Val Ala Gln Pro Gln Val Asn Pro Thr Leu Gln Pro Arg Ser 
        355                 360                 365             


Asp Pro Thr Ala Gln Pro Gln Leu Asn Pro Thr Ala Gln Pro Gln Ser 
    370                 375                 380                 


Asp Pro Thr Ala Gln Pro Gln Leu Asn Leu Met Ala Gln Pro Gln Ser 
385                 390                 395                 400 


Asp Ser Val Ala Gln Pro Gln Ala Asp Thr Asn Val Gln Thr Pro Ala 
                405                 410                 415     


Pro Ala Ala Ser Ser Val Pro Ser Pro Cys Asp Glu Ala Ser Pro Thr 
            420                 425                 430         


Pro Ser Ser His Pro Thr Pro Gly Ala Leu Glu Asp Pro Ala Thr Pro 
        435                 440                 445             


Pro Ala Ser Glu Gly Glu Ser Pro Ser Ser Thr Pro Pro Glu Ala Ala 
    450                 455                 460                 


Pro Gly Ala Gly Pro Thr 
465                 470 


<210>  4645
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR153__Homo_sapiens__XP_011539736

<400>  4645

Met Ser Asp Glu Arg Arg Leu Pro Gly Ser Ala Val Gly Trp Leu Val 
1               5                   10                  15      


Cys Gly Gly Leu Ser Leu Leu Ala Asn Ala Trp Gly Ile Leu Ser Val 
            20                  25                  30          


Gly Ala Lys Gln Lys Lys Trp Lys Pro Leu Glu Phe Leu Leu Cys Thr 
        35                  40                  45              


Leu Ala Ala Thr His Met Leu Asn Val Ala Val Pro Ile Ala Thr Tyr 
    50                  55                  60                  


Ser Val Val Gln Leu Arg Arg Gln Arg Pro Asp Phe Glu Trp Asn Glu 
65                  70                  75                  80  


Gly Leu Cys Lys Val Phe Val Ser Thr Phe Tyr Thr Leu Thr Leu Ala 
                85                  90                  95      


Thr Cys Phe Ser Val Thr Ser Leu Ser Tyr His Arg Met Trp Met Val 
            100                 105                 110         


Cys Trp Pro Val Asn Tyr Arg Leu Ser Asn Ala Lys Lys Gln Ala Val 
        115                 120                 125             


His Thr Val Met Gly Ile Trp Met Val Ser Phe Ile Leu Ser Ala Leu 
    130                 135                 140                 


Pro Ala Val Gly Trp His Asp Thr Ser Glu Arg Phe Tyr Thr His Gly 
145                 150                 155                 160 


Cys Arg Phe Ile Val Ala Glu Ile Gly Leu Gly Phe Gly Val Cys Phe 
                165                 170                 175     


Leu Leu Leu Val Gly Gly Ser Val Ala Met Gly Val Ile Cys Thr Ala 
            180                 185                 190         


Ile Ala Leu Phe Gln Thr Leu Ala Val Gln Val Gly Arg Gln Ala Asp 
        195                 200                 205             


Arg Arg Ala Phe Thr Val Pro Thr Ile Val Val Glu Asp Ala Gln Gly 
    210                 215                 220                 


Lys Arg Arg Ser Ser Ile Asp Gly Ser Glu Pro Ala Lys Thr Ser Leu 
225                 230                 235                 240 


Gln Thr Thr Gly Leu Val Thr Thr Ile Val Phe Ile Tyr Asp Cys Leu 
                245                 250                 255     


Met Gly Phe Pro Val Leu Val Val Ser Phe Ser Ser Leu Arg Ala Asp 
            260                 265                 270         


Ala Ser Ala Pro Trp Met Ala Leu Cys Val Leu Trp Cys Ser Val Ala 
        275                 280                 285             


Gln Ala Leu Leu Leu Pro Val Phe Leu Trp Ala Cys Asp Arg Tyr Arg 
    290                 295                 300                 


Ala Asp Leu Lys Ala Val Arg Glu Lys Cys Met Ala Leu Met Ala Asn 
305                 310                 315                 320 


Asp Glu Glu Ser Asp Asp Glu Thr Ser Leu Glu Gly Gly Ile Ser Pro 
                325                 330                 335     


Asp Leu Val Leu Glu Arg Ser Leu Asp Tyr Gly Tyr Gly Gly Asp Phe 
            340                 345                 350         


Val Ala Leu Asp Arg Met Ala Lys Tyr Glu Ile Ser Ala Leu Glu Gly 
        355                 360                 365             


Gly Leu Pro Gln Leu Tyr Pro Leu Arg Pro Leu Gln Glu Asp Lys Met 
    370                 375                 380                 


Gln Tyr Leu Gln Val Pro Pro Thr Arg Arg Phe Ser His Asp Asp Ala 
385                 390                 395                 400 


Asp Val Trp Ala Ala Val Pro Leu Pro Ala Phe Leu Pro Arg Trp Gly 
                405                 410                 415     


Ser Gly Glu Asp Leu Ala Ala Leu Ala His Leu Val Leu Pro Ala Gly 
            420                 425                 430         


Pro Glu Arg Arg Arg Ala Ser Leu Leu Ala Phe Ala Glu Asp Ala Pro 
        435                 440                 445             


Pro Ser Arg Ala Arg Arg Arg Ser Ala Glu Ser Leu Leu Ser Leu Arg 
    450                 455                 460                 


Pro Ser Ala Leu Asp Ser Gly Pro Arg Gly Ala Arg Asp Ser Pro Pro 
465                 470                 475                 480 


Gly Ser Pro Arg Arg Arg Pro Gly Pro Gly Pro Arg Ser Ala Ser Ala 
                485                 490                 495     


Ser Leu Leu Pro Asp Ala Phe Ala Leu Thr Ala Phe Glu Cys Glu Pro 
            500                 505                 510         


Gln Ala Leu Arg Arg Pro Pro Gly Pro Phe Pro Ala Ala Pro Ala Ala 
        515                 520                 525             


Pro Asp Gly Ala Asp Pro Gly Glu Ala Pro Thr Pro Pro Ser Ser Ala 
    530                 535                 540                 


Gln Arg Ser Pro Gly Pro Arg Pro Ser Ala His Ser His Ala Gly Ser 
545                 550                 555                 560 


Leu Arg Pro Gly Leu Ser Ala Ser Trp Gly Glu Pro Gly Gly Leu Arg 
                565                 570                 575     


Ala Ala Gly Gly Gly Gly Ser Thr Ser Ser Phe Leu Ser Ser Pro Ser 
            580                 585                 590         


Glu Ser Ser Gly Tyr Ala Thr Leu His Ser Asp Ser Leu Gly Ser Ala 
        595                 600                 605             


Ser 
    


<210>  4646
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR155__Homo_sapiens__NP_001253980

<400>  4646

Met Asn Ser Asn Leu Pro Ala Glu Asn Leu Thr Ile Ala Val Asn Met 
1               5                   10                  15      


Thr Lys Thr Leu Pro Thr Ala Val Thr His Gly Phe Asn Ser Thr Asn 
            20                  25                  30          


Asp Pro Pro Ser Met Ser Ile Thr Arg Leu Phe Pro Ala Leu Leu Glu 
        35                  40                  45              


Cys Phe Gly Ile Val Leu Cys Gly Tyr Ile Ala Gly Arg Ala Asn Val 
    50                  55                  60                  


Ile Thr Ser Thr Gln Ala Lys Gly Leu Gly Asn Phe Val Ser Arg Phe 
65                  70                  75                  80  


Ala Leu Pro Ala Leu Leu Phe Lys Asn Met Val Val Leu Asn Phe Ser 
                85                  90                  95      


Asn Val Asp Trp Ser Phe Leu Tyr Ser Ile Leu Ile Ala Lys Ala Ser 
            100                 105                 110         


Val Phe Phe Ile Val Cys Val Leu Thr Leu Leu Val Ala Ser Pro Asp 
        115                 120                 125             


Ser Arg Phe Ser Lys Ala Gly Leu Phe Pro Ile Phe Ala Thr Gln Ser 
    130                 135                 140                 


Asn Asp Phe Ala Leu Gly Tyr Pro Ile Val Glu Ala Leu Tyr Gln Thr 
145                 150                 155                 160 


Thr Tyr Pro Glu Tyr Leu Gln Tyr Ile Tyr Leu Val Ala Pro Ile Ser 
                165                 170                 175     


Leu Met Met Leu Asn Pro Ile Gly Phe Ile Phe Cys Glu Ile Gln Lys 
            180                 185                 190         


Trp Lys Asp Thr Gln Asn Ala Ser Gln Asn Lys Ile Lys Ile Val Gly 
        195                 200                 205             


Leu Gly Leu Leu Arg Val Leu Gln Asn Pro Ile Val Phe Met Val Phe 
    210                 215                 220                 


Ile Gly Ile Ala Phe Asn Phe Ile Leu Asp Arg Lys Val Pro Val Tyr 
225                 230                 235                 240 


Val Glu Asn Phe Leu Asp Gly Leu Gly Asn Ser Phe Ser Gly Ser Ala 
                245                 250                 255     


Leu Phe Tyr Leu Gly Leu Thr Met Val Gly Lys Ile Lys Arg Leu Lys 
            260                 265                 270         


Lys Ser Ala Phe Val Val Leu Ile Leu Leu Ile Thr Ala Lys Leu Leu 
        275                 280                 285             


Val Leu Pro Leu Leu Cys Arg Glu Met Val Glu Leu Leu Asp Lys Gly 
    290                 295                 300                 


Asp Ser Val Val Asn His Thr Ser Leu Ser Asn Tyr Ala Phe Leu Tyr 
305                 310                 315                 320 


Gly Val Phe Pro Val Ala Pro Gly Val Ala Ile Phe Ala Thr Gln Phe 
                325                 330                 335     


Asn Met Glu Val Glu Ile Ile Thr Ser Gly Met Val Ile Ser Thr Phe 
            340                 345                 350         


Val Ser Ala Pro Ile Met Tyr Val Ser Ala Trp Leu Leu Thr Phe Pro 
        355                 360                 365             


Thr Met Asp Pro Lys Pro Leu Ala Tyr Ala Ile Gln Asn Val Ser Phe 
    370                 375                 380                 


Asp Ile Ser Ile Val Ser Leu Ile Ser Leu Ser Ile Val Cys Ala Gly 
385                 390                 395                 400 


Met Met Ile Trp Asn Phe Val Lys Glu Lys Asn Phe Val Gly Gln Ile 
                405                 410                 415     


Leu Val Phe Val Leu Leu Tyr Ser Ser Leu Tyr Ser Thr Tyr Leu Trp 
            420                 425                 430         


Thr Gly Leu Leu Ala Ile Ser Leu Phe Leu Leu Lys Lys Arg Glu Arg 
        435                 440                 445             


Val Gln Ile Pro Val Gly Ile Ile Ile Ile Ser Gly Trp Gly Ile Pro 
    450                 455                 460                 


Ala Leu Leu Val Gly Val Leu Leu Ile Thr Gly Lys His Asn Gly Asp 
465                 470                 475                 480 


Ser Ile Asp Ser Ala Phe Phe Tyr Gly Lys Glu Gln Met Ile Thr Thr 
                485                 490                 495     


Ala Val Thr Leu Phe Cys Ser Ile Leu Ile Ala Gly Ile Ser Leu Met 
            500                 505                 510         


Cys Met Asn Gln Thr Ala Gln Ala Gly Ser Tyr Glu Gly Phe Asp Gln 
        515                 520                 525             


Ser Gln Ser His Lys Val Val Glu Pro Gly Asn Thr Ala Phe Glu Glu 
    530                 535                 540                 


Ser Pro Ala Pro Val Asn Glu Pro Glu Leu Phe Thr Ser Ser Ile Pro 
545                 550                 555                 560 


Glu Thr Ser Cys Cys Ser Cys Ser Met Gly Asn Gly Glu Leu His Cys 
                565                 570                 575     


Pro Ser Ile Glu Pro Ile Ala Asn Thr Ser Thr Ser Glu Pro Val Ile 
            580                 585                 590         


Pro Ser Phe Glu Lys Asn Asn His Cys Val Ser Arg Cys Asn Ser Gln 
        595                 600                 605             


Ser Cys Ile Leu Ala Gln Glu Glu Glu Gln Tyr Leu Gln Ser Gly Asp 
    610                 615                 620                 


Gln Gln Leu Thr Arg His Val Leu Leu Cys Leu Leu Leu Ile Ile Gly 
625                 630                 635                 640 


Leu Phe Ala Asn Leu Ser Ser Cys Leu Trp Trp Leu Phe Asn Gln Glu 
                645                 650                 655     


Pro Gly Arg Leu Tyr Val Glu Leu Gln Phe Phe Cys Ala Val Phe Asn 
            660                 665                 670         


Phe Gly Gln Gly Phe Ile Ser Phe Gly Ile Phe Gly Leu Asp Lys His 
        675                 680                 685             


Leu Ile Ile Leu Pro Phe Lys Arg Arg Leu Glu Phe Leu Trp Asn Asn 
    690                 695                 700                 


Lys Asp Thr Ala Glu Asn Arg Asp Ser Pro Val Ser Glu Glu Ile Lys 
705                 710                 715                 720 


Met Thr Cys Gln Gln Phe Ile His Tyr His Arg Asp Leu Cys Ile Arg 
                725                 730                 735     


Asn Ile Val Lys Glu Arg Arg Cys Gly Ala Lys Thr Ser Ala Gly Thr 
            740                 745                 750         


Phe Cys Gly Cys Asp Leu Val Ser Trp Leu Ile Glu Val Gly Leu Ala 
        755                 760                 765             


Ser Asp Arg Gly Glu Ala Val Ile Tyr Gly Asp Arg Leu Val Gln Gly 
    770                 775                 780                 


Gly Val Ile Gln His Ile Thr Asn Glu Tyr Glu Phe Arg Asp Glu Tyr 
785                 790                 795                 800 


Leu Phe Tyr Arg Phe Leu Gln Lys Ser Pro Glu Gln Ser Pro Pro Ala 
                805                 810                 815     


Ile Asn Ala Asn Thr Leu Gln Gln Glu Arg Tyr Lys Glu Ile Glu His 
            820                 825                 830         


Ser Ser Pro Pro Ser His Ser Pro Lys Thr 
        835                 840         


<210>  4647
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR156__Homo_sapiens__NP_001161743

<400>  4647

Met Glu Pro Glu Ile Asn Cys Ser Glu Leu Cys Asp Ser Phe Pro Gly 
1               5                   10                  15      


Gln Glu Leu Asp Arg Arg Pro Leu His Asp Leu Cys Lys Thr Thr Ile 
            20                  25                  30          


Thr Ser Ser His His Ser Ser Lys Thr Ile Ser Ser Leu Ser Pro Val 
        35                  40                  45              


Leu Leu Gly Ile Val Trp Thr Phe Leu Ser Cys Gly Leu Leu Leu Ile 
    50                  55                  60                  


Leu Phe Phe Leu Ala Phe Thr Ile His Cys Arg Lys Asn Arg Ile Val 
65                  70                  75                  80  


Lys Met Ser Ser Pro Asn Leu Asn Ile Val Thr Leu Leu Gly Ser Cys 
                85                  90                  95      


Leu Thr Tyr Ser Ser Ala Tyr Leu Phe Gly Ile Gln Asp Val Leu Val 
            100                 105                 110         


Gly Ser Ser Met Glu Thr Leu Ile Gln Thr Arg Leu Ser Met Leu Cys 
        115                 120                 125             


Ile Gly Thr Ser Leu Val Phe Gly Pro Ile Leu Gly Lys Ser Trp Arg 
    130                 135                 140                 


Leu Tyr Lys Val Phe Thr Gln Arg Val Pro Asp Lys Arg Val Ile Ile 
145                 150                 155                 160 


Lys Asp Leu Gln Leu Leu Gly Leu Val Ala Ala Leu Leu Met Ala Asp 
                165                 170                 175     


Val Ile Leu Leu Met Thr Trp Val Leu Thr Asp Pro Ile Gln Cys Leu 
            180                 185                 190         


Gln Ile Leu Ser Val Thr Gly Lys Asp Val Ser Cys Thr Ser Thr Ser 
        195                 200                 205             


Thr His Phe Cys Ala Ser Arg Tyr Ser Asp Val Trp Ile Ala Leu Ile 
    210                 215                 220                 


Trp Gly Cys Lys Gly Leu Leu Leu Leu Tyr Gly Ala Tyr Leu Ala Gly 
225                 230                 235                 240 


Leu Thr Gly His Val Ser Ser Pro Pro Val Asn Gln Ser Leu Thr Ile 
                245                 250                 255     


Met Val Gly Val Asn Leu Leu Val Leu Ala Ala Gly Leu Leu Phe Val 
            260                 265                 270         


Val Thr Arg Tyr Leu His Ser Trp Pro Asn Leu Val Phe Gly Leu Thr 
        275                 280                 285             


Ser Gly Gly Ile Phe Val Cys Thr Thr Thr Ile Asn Cys Phe Ile Phe 
    290                 295                 300                 


Ile Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu Glu Asn Gln Thr 
305                 310                 315                 320 


Ile Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn Lys Ser Phe His 
                325                 330                 335     


Thr Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg Gly Glu Lys Ser 
            340                 345                 350         


Ser Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val Ile Glu Ser Leu 
        355                 360                 365             


Gln Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val Arg Leu Met Ser 
    370                 375                 380                 


Ala Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala Pro Pro Ala Ser 
385                 390                 395                 400 


Ser Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val His Thr Leu Ala 
                405                 410                 415     


Ala Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe Gln Asn Asp Pro 
            420                 425                 430         


Gly Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly Pro Ser Ser Tyr 
        435                 440                 445             


Ala Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser Phe Ser Pro Gly 
    450                 455                 460                 


Lys Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser Asp His Leu Asp 
465                 470                 475                 480 


Ser Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser Leu Gly Pro Glu 
                485                 490                 495     


Arg Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser Leu Leu Pro Glu 
            500                 505                 510         


Arg Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu Glu Asn Ser Glu 
        515                 520                 525             


Glu Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val Ile Arg Glu Lys 
    530                 535                 540                 


Leu Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro Glu Ala Ser Leu 
545                 550                 555                 560 


Ser Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys Asn Ser Ala Ala 
                565                 570                 575     


Phe Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu Gly Phe Ser Pro 
            580                 585                 590         


Tyr Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala Arg Ser His Phe 
        595                 600                 605             


Pro Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala Asn Arg Thr Val 
    610                 615                 620                 


Pro Gly Ala His Ser Arg Leu His Val Gln Asn Gly Asp Ser Pro Ser 
625                 630                 635                 640 


Leu Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg Pro Ser Ser Arg 
                645                 650                 655     


Lys Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro Gly Thr Leu Glu 
            660                 665                 670         


Gly Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala Arg Gly Ser Lys 
        675                 680                 685             


Ala Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg Ala Pro Ser Pro 
    690                 695                 700                 


Ala Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu Pro Glu Gln Trp 
705                 710                 715                 720 


Gln Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser Leu Ser Ser Gln 
                725                 730                 735     


His Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp Glu Phe Phe Cys 
            740                 745                 750         


Arg Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln Ser Ser Ser Asp 
        755                 760                 765             


Ser Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu Pro Thr Gly Gly 
    770                 775                 780                 


Leu Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys Pro Ile Val Asn 
785                 790                 795                 800 


Phe Lys Asp Asp Leu Lys Pro Thr Leu Val 
                805                 810 


<210>  4648
<211>  1215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR158__Homo_sapiens__NP_065803

<400>  4648

Met Gly Ala Met Ala Tyr Pro Leu Leu Leu Cys Leu Leu Leu Ala Gln 
1               5                   10                  15      


Leu Gly Leu Gly Ala Val Gly Ala Ser Arg Asp Pro Gln Gly Arg Pro 
            20                  25                  30          


Asp Ser Pro Arg Glu Arg Thr Pro Lys Gly Lys Pro His Ala Gln Gln 
        35                  40                  45              


Pro Gly Arg Ala Ser Ala Ser Asp Ser Ser Ala Pro Trp Ser Arg Ser 
    50                  55                  60                  


Thr Asp Gly Thr Ile Leu Ala Gln Lys Leu Ala Glu Glu Val Pro Met 
65                  70                  75                  80  


Asp Val Ala Ser Tyr Leu Tyr Thr Gly Asp Ser His Gln Leu Lys Arg 
                85                  90                  95      


Ala Asn Cys Ser Gly Arg Tyr Glu Leu Ala Gly Leu Pro Gly Lys Trp 
            100                 105                 110         


Pro Ala Leu Ala Ser Ala His Pro Ser Leu His Arg Ala Leu Asp Thr 
        115                 120                 125             


Leu Thr His Ala Thr Asn Phe Leu Asn Val Met Leu Gln Ser Asn Lys 
    130                 135                 140                 


Ser Arg Glu Gln Asn Leu Gln Asp Asp Leu Asp Trp Tyr Gln Ala Leu 
145                 150                 155                 160 


Val Trp Ser Leu Leu Glu Gly Glu Pro Ser Ile Ser Arg Ala Ala Ile 
                165                 170                 175     


Thr Phe Ser Thr Asp Ser Leu Ser Ala Pro Ala Pro Gln Val Phe Leu 
            180                 185                 190         


Gln Ala Thr Arg Glu Glu Ser Arg Ile Leu Leu Gln Asp Leu Ser Ser 
        195                 200                 205             


Ser Ala Pro His Leu Ala Asn Ala Thr Leu Glu Thr Glu Trp Phe His 
    210                 215                 220                 


Gly Leu Arg Arg Lys Trp Arg Pro His Leu His Arg Arg Gly Pro Asn 
225                 230                 235                 240 


Gln Gly Pro Arg Gly Leu Gly His Ser Trp Arg Arg Lys Asp Gly Leu 
                245                 250                 255     


Gly Gly Asp Lys Ser His Phe Lys Trp Ser Pro Pro Tyr Leu Glu Cys 
            260                 265                 270         


Glu Asn Gly Ser Tyr Lys Pro Gly Trp Leu Val Thr Leu Ser Ser Ala 
        275                 280                 285             


Ile Tyr Gly Leu Gln Pro Asn Leu Val Pro Glu Phe Arg Gly Val Met 
    290                 295                 300                 


Lys Val Asp Ile Asn Leu Gln Lys Val Asp Ile Asp Gln Cys Ser Ser 
305                 310                 315                 320 


Asp Gly Trp Phe Ser Gly Thr His Lys Cys His Leu Asn Asn Ser Glu 
                325                 330                 335     


Cys Met Pro Ile Lys Gly Leu Gly Phe Val Leu Gly Ala Tyr Glu Cys 
            340                 345                 350         


Ile Cys Lys Ala Gly Phe Tyr His Pro Gly Val Leu Pro Val Asn Asn 
        355                 360                 365             


Phe Arg Arg Arg Gly Pro Asp Gln His Ile Ser Gly Ser Thr Lys Asp 
    370                 375                 380                 


Val Ser Glu Glu Ala Tyr Val Cys Leu Pro Cys Arg Glu Gly Cys Pro 
385                 390                 395                 400 


Phe Cys Ala Asp Asp Ser Pro Cys Phe Val Gln Glu Asp Lys Tyr Leu 
                405                 410                 415     


Arg Leu Ala Ile Ile Ser Phe Gln Ala Leu Cys Met Leu Leu Asp Phe 
            420                 425                 430         


Val Ser Met Leu Val Val Tyr His Phe Arg Lys Ala Lys Ser Ile Arg 
        435                 440                 445             


Ala Ser Gly Leu Ile Leu Leu Glu Thr Ile Leu Phe Gly Ser Leu Leu 
    450                 455                 460                 


Leu Tyr Phe Pro Val Val Ile Leu Tyr Phe Glu Pro Ser Thr Phe Arg 
465                 470                 475                 480 


Cys Ile Leu Leu Arg Trp Ala Arg Leu Leu Gly Phe Ala Thr Val Tyr 
                485                 490                 495     


Gly Thr Val Thr Leu Lys Leu His Arg Val Leu Lys Val Phe Leu Ser 
            500                 505                 510         


Arg Thr Ala Gln Arg Ile Pro Tyr Met Thr Gly Gly Arg Val Met Arg 
        515                 520                 525             


Met Leu Ala Val Ile Leu Leu Val Val Phe Trp Phe Leu Ile Gly Trp 
    530                 535                 540                 


Thr Ser Ser Val Cys Gln Asn Leu Glu Lys Gln Ile Ser Leu Ile Gly 
545                 550                 555                 560 


Gln Gly Lys Thr Ser Asp His Leu Ile Phe Asn Met Cys Leu Ile Asp 
                565                 570                 575     


Arg Trp Asp Tyr Met Thr Ala Val Ala Glu Phe Leu Phe Leu Leu Trp 
            580                 585                 590         


Gly Val Tyr Leu Cys Tyr Ala Val Arg Thr Val Pro Ser Ala Phe His 
        595                 600                 605             


Glu Pro Arg Tyr Met Ala Val Ala Val His Asn Glu Leu Ile Ile Ser 
    610                 615                 620                 


Ala Ile Phe His Thr Ile Arg Phe Val Leu Ala Ser Arg Leu Gln Ser 
625                 630                 635                 640 


Asp Trp Met Leu Met Leu Tyr Phe Ala His Thr His Leu Thr Val Thr 
                645                 650                 655     


Val Thr Ile Gly Leu Leu Leu Ile Pro Lys Phe Ser His Ser Ser Asn 
            660                 665                 670         


Asn Pro Arg Asp Asp Ile Ala Thr Glu Ala Tyr Glu Asp Glu Leu Asp 
        675                 680                 685             


Met Gly Arg Ser Gly Ser Tyr Leu Asn Ser Ser Ile Asn Ser Ala Trp 
    690                 695                 700                 


Ser Glu His Ser Leu Asp Pro Glu Asp Ile Arg Asp Glu Leu Lys Lys 
705                 710                 715                 720 


Leu Tyr Ala Gln Leu Glu Ile Tyr Lys Arg Lys Lys Met Ile Thr Asn 
                725                 730                 735     


Asn Pro His Leu Gln Lys Lys Arg Cys Ser Lys Lys Gly Leu Gly Arg 
            740                 745                 750         


Ser Ile Met Arg Arg Ile Thr Glu Ile Pro Glu Thr Val Ser Arg Gln 
        755                 760                 765             


Cys Ser Lys Glu Asp Lys Glu Gly Ala Asp His Gly Thr Ala Lys Gly 
    770                 775                 780                 


Thr Ala Leu Ile Arg Lys Asn Pro Pro Glu Ser Ser Gly Asn Thr Gly 
785                 790                 795                 800 


Lys Ser Lys Glu Glu Thr Leu Lys Asn Arg Val Phe Ser Leu Lys Lys 
                805                 810                 815     


Ser His Ser Thr Tyr Asp His Val Arg Asp Gln Thr Glu Glu Ser Ser 
            820                 825                 830         


Ser Leu Pro Thr Glu Ser Gln Glu Glu Glu Thr Thr Glu Asn Ser Thr 
        835                 840                 845             


Leu Glu Ser Leu Ser Gly Lys Lys Leu Thr Gln Lys Leu Lys Glu Asp 
    850                 855                 860                 


Ser Glu Ala Glu Ser Thr Glu Ser Val Pro Leu Val Cys Lys Ser Ala 
865                 870                 875                 880 


Ser Ala His Asn Leu Ser Ser Glu Lys Lys Thr Gly His Pro Arg Thr 
                885                 890                 895     


Ser Met Leu Gln Lys Ser Leu Ser Val Ile Ala Ser Ala Lys Glu Lys 
            900                 905                 910         


Thr Leu Gly Leu Ala Gly Lys Thr Gln Thr Ala Gly Val Glu Glu Arg 
        915                 920                 925             


Thr Lys Ser Gln Lys Pro Leu Pro Lys Asp Lys Glu Thr Asn Arg Asn 
    930                 935                 940                 


His Ser Asn Ser Asp Asn Thr Glu Thr Lys Asp Pro Ala Pro Gln Asn 
945                 950                 955                 960 


Ser Asn Pro Ala Glu Glu Pro Arg Lys Pro Gln Lys Ser Gly Ile Met 
                965                 970                 975     


Lys Gln Gln Arg Val Asn Pro Thr Thr Ala Asn Ser Asp Leu Asn Pro 
            980                 985                 990         


Gly Thr Thr Gln Met Lys Asp Asn  Phe Asp Ile Gly Glu  Val Cys Pro 
        995                 1000                 1005             


Trp Glu  Val Tyr Asp Leu Thr  Pro Gly Pro Val Pro  Ser Glu Ser 
    1010                 1015                 1020             


Lys Val  Gln Lys His Val Ser  Ile Val Ala Ser Glu  Met Glu Lys 
    1025                 1030                 1035             


Asn Pro  Thr Phe Ser Leu Lys  Glu Lys Ser His His  Lys Pro Lys 
    1040                 1045                 1050             


Ala Ala  Glu Val Cys Gln Gln  Ser Asn Gln Lys Arg  Ile Asp Lys 
    1055                 1060                 1065             


Ala Glu  Val Cys Leu Trp Glu  Ser Gln Gly Gln Ser  Ile Leu Glu 
    1070                 1075                 1080             


Asp Glu  Lys Leu Leu Ile Ser  Lys Thr Pro Val Leu  Pro Glu Arg 
    1085                 1090                 1095             


Ala Lys  Glu Glu Asn Gly Gly  Gln Pro Arg Ala Ala  Asn Val Cys 
    1100                 1105                 1110             


Ala Gly  Gln Ser Glu Glu Leu  Pro Pro Lys Ala Val  Ala Ser Lys 
    1115                 1120                 1125             


Thr Glu  Asn Glu Asn Leu Asn  Gln Ile Gly His Gln  Glu Lys Lys 
    1130                 1135                 1140             


Thr Ser  Ser Ser Glu Glu Asn  Val Arg Gly Ser Tyr  Asn Ser Ser 
    1145                 1150                 1155             


Asn Asn  Phe Gln Gln Pro Leu  Thr Ser Arg Ala Glu  Val Cys Pro 
    1160                 1165                 1170             


Trp Glu  Phe Glu Thr Pro Ala  Gln Pro Asn Ala Gly  Arg Ser Val 
    1175                 1180                 1185             


Ala Leu  Pro Ala Ser Ser Ala  Leu Ser Ala Asn Lys  Ile Ala Gly 
    1190                 1195                 1200             


Pro Arg  Lys Glu Glu Ile Trp  Asp Ser Phe Lys Val  
    1205                 1210                 1215 


<210>  4649
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR15__Homo_sapiens__NP_005281

<400>  4649

Met Asp Pro Glu Glu Thr Ser Val Tyr Leu Asp Tyr Tyr Tyr Ala Thr 
1               5                   10                  15      


Ser Pro Asn Ser Asp Ile Arg Glu Thr His Ser His Val Pro Tyr Thr 
            20                  25                  30          


Ser Val Phe Leu Pro Val Phe Tyr Thr Ala Val Phe Leu Thr Gly Val 
        35                  40                  45              


Leu Gly Asn Leu Val Leu Met Gly Ala Leu His Phe Lys Pro Gly Ser 
    50                  55                  60                  


Arg Arg Leu Ile Asp Ile Phe Ile Ile Asn Leu Ala Ala Ser Asp Phe 
65                  70                  75                  80  


Ile Phe Leu Val Thr Leu Pro Leu Trp Val Asp Lys Glu Ala Ser Leu 
                85                  90                  95      


Gly Leu Trp Arg Thr Gly Ser Phe Leu Cys Lys Gly Ser Ser Tyr Met 
            100                 105                 110         


Ile Ser Val Asn Met His Cys Ser Val Leu Leu Leu Thr Cys Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Ile Val Trp Pro Val Val Ser Arg Lys Phe 
    130                 135                 140                 


Arg Arg Thr Asp Cys Ala Tyr Val Val Cys Ala Ser Ile Trp Phe Ile 
145                 150                 155                 160 


Ser Cys Leu Leu Gly Leu Pro Thr Leu Leu Ser Arg Glu Leu Thr Leu 
                165                 170                 175     


Ile Asp Asp Lys Pro Tyr Cys Ala Glu Lys Lys Ala Thr Pro Ile Lys 
            180                 185                 190         


Leu Ile Trp Ser Leu Val Ala Leu Ile Phe Thr Phe Phe Val Pro Leu 
        195                 200                 205             


Leu Ser Ile Val Thr Cys Tyr Cys Cys Ile Ala Arg Lys Leu Cys Ala 
    210                 215                 220                 


His Tyr Gln Gln Ser Gly Lys His Asn Lys Lys Leu Lys Lys Ser Ile 
225                 230                 235                 240 


Lys Ile Ile Phe Ile Val Val Ala Ala Phe Leu Val Ser Trp Leu Pro 
                245                 250                 255     


Phe Asn Thr Phe Lys Phe Leu Ala Ile Val Ser Gly Leu Arg Gln Glu 
            260                 265                 270         


His Tyr Leu Pro Ser Ala Ile Leu Gln Leu Gly Met Glu Val Ser Gly 
        275                 280                 285             


Pro Leu Ala Phe Ala Asn Ser Cys Val Asn Pro Phe Ile Tyr Tyr Ile 
    290                 295                 300                 


Phe Asp Ser Tyr Ile Arg Arg Ala Ile Val His Cys Leu Cys Pro Cys 
305                 310                 315                 320 


Leu Lys Asn Tyr Asp Phe Gly Ser Ser Thr Glu Thr Ser Asp Ser His 
                325                 330                 335     


Leu Thr Lys Ala Leu Ser Thr Phe Ile His Ala Glu Asp Phe Ala Arg 
            340                 345                 350         


Arg Arg Lys Arg Ser Val Ser Leu 
        355                 360 


<210>  4650
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR160__Homo_sapiens__NP_055188

<400>  4650

Met Thr Ala Leu Ser Ser Glu Asn Cys Ser Phe Gln Tyr Gln Leu Arg 
1               5                   10                  15      


Gln Thr Asn Gln Pro Leu Asp Val Asn Tyr Leu Leu Phe Leu Ile Ile 
            20                  25                  30          


Leu Gly Lys Ile Leu Leu Asn Ile Leu Thr Leu Gly Met Arg Arg Lys 
        35                  40                  45              


Asn Thr Cys Gln Asn Phe Met Glu Tyr Phe Cys Ile Ser Leu Ala Phe 
    50                  55                  60                  


Val Asp Leu Leu Leu Leu Val Asn Ile Ser Ile Ile Leu Tyr Phe Arg 
65                  70                  75                  80  


Asp Phe Val Leu Leu Ser Ile Arg Phe Thr Lys Tyr His Ile Cys Leu 
                85                  90                  95      


Phe Thr Gln Ile Ile Ser Phe Thr Tyr Gly Phe Leu His Tyr Pro Val 
            100                 105                 110         


Phe Leu Thr Ala Cys Ile Asp Tyr Cys Leu Asn Phe Ser Lys Thr Thr 
        115                 120                 125             


Lys Leu Ser Phe Lys Cys Gln Lys Leu Phe Tyr Phe Phe Thr Val Ile 
    130                 135                 140                 


Leu Ile Trp Ile Ser Val Leu Ala Tyr Val Leu Gly Asp Pro Ala Ile 
145                 150                 155                 160 


Tyr Gln Ser Leu Lys Ala Gln Asn Ala Tyr Ser Arg His Cys Pro Phe 
                165                 170                 175     


Tyr Val Ser Ile Gln Ser Tyr Trp Leu Ser Phe Phe Met Val Met Ile 
            180                 185                 190         


Leu Phe Val Ala Phe Ile Thr Cys Trp Glu Glu Val Thr Thr Leu Val 
        195                 200                 205             


Gln Ala Ile Arg Ile Thr Ser Tyr Met Asn Glu Thr Ile Leu Tyr Phe 
    210                 215                 220                 


Pro Phe Ser Ser His Ser Ser Tyr Thr Val Arg Ser Lys Lys Ile Phe 
225                 230                 235                 240 


Leu Ser Lys Leu Ile Val Cys Phe Leu Ser Thr Trp Leu Pro Phe Val 
                245                 250                 255     


Leu Leu Gln Val Ile Ile Val Leu Leu Lys Val Gln Ile Pro Ala Tyr 
            260                 265                 270         


Ile Glu Met Asn Ile Pro Trp Leu Tyr Phe Val Asn Ser Phe Leu Ile 
        275                 280                 285             


Ala Thr Val Tyr Trp Phe Asn Cys His Lys Leu Asn Leu Lys Asp Ile 
    290                 295                 300                 


Gly Leu Pro Leu Asp Pro Phe Val Asn Trp Lys Cys Cys Phe Ile Pro 
305                 310                 315                 320 


Leu Thr Ile Pro Asn Leu Glu Gln Ile Glu Lys Pro Ile Ser Ile Met 
                325                 330                 335     


Ile Cys 
        


<210>  4651
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR161__Homo_sapiens__NP_001254540

<400>  4651

Met Lys Val Val Gln His Ala Leu Pro Thr Pro Arg Arg Gly Ala Leu 
1               5                   10                  15      


Thr Met Ser Leu Asn Ser Ser Leu Ser Cys Arg Lys Glu Leu Ser Asn 
            20                  25                  30          


Leu Thr Glu Glu Glu Gly Gly Glu Gly Gly Val Ile Ile Thr Gln Phe 
        35                  40                  45              


Ile Ala Ile Ile Val Ile Thr Ile Phe Val Cys Leu Gly Asn Leu Val 
    50                  55                  60                  


Ile Val Val Thr Leu Tyr Lys Lys Ser Tyr Leu Leu Thr Leu Ser Asn 
65                  70                  75                  80  


Lys Phe Val Phe Ser Leu Thr Leu Ser Asn Phe Leu Leu Ser Val Leu 
                85                  90                  95      


Val Leu Pro Phe Val Val Thr Ser Ser Ile Arg Arg Glu Trp Ile Phe 
            100                 105                 110         


Gly Val Val Trp Cys Asn Phe Ser Ala Leu Leu Tyr Leu Leu Ile Ser 
        115                 120                 125             


Ser Ala Ser Met Leu Thr Leu Gly Val Ile Ala Ile Asp Arg Tyr Tyr 
    130                 135                 140                 


Ala Val Leu Tyr Pro Met Val Tyr Pro Met Lys Ile Thr Gly Asn Arg 
145                 150                 155                 160 


Ala Val Met Ala Leu Val Tyr Ile Trp Leu His Ser Leu Ile Gly Cys 
                165                 170                 175     


Leu Pro Pro Leu Phe Gly Trp Ser Ser Val Glu Phe Asp Glu Phe Lys 
            180                 185                 190         


Trp Met Cys Val Ala Ala Trp His Arg Glu Pro Gly Tyr Thr Ala Phe 
        195                 200                 205             


Trp Gln Ile Trp Cys Ala Leu Phe Pro Phe Leu Val Met Leu Val Cys 
    210                 215                 220                 


Tyr Gly Phe Ile Phe Arg Val Ala Arg Val Lys Ala Arg Lys Val His 
225                 230                 235                 240 


Cys Gly Thr Val Val Ile Val Glu Glu Asp Ala Gln Arg Thr Gly Arg 
                245                 250                 255     


Lys Asn Ser Ser Thr Ser Thr Ser Ser Ser Gly Ser Arg Arg Asn Ala 
            260                 265                 270         


Phe Gln Gly Val Val Tyr Ser Ala Asn Gln Cys Lys Ala Leu Ile Thr 
        275                 280                 285             


Ile Leu Val Val Leu Gly Ala Phe Met Val Thr Trp Gly Pro Tyr Met 
    290                 295                 300                 


Val Val Ile Ala Ser Glu Ala Leu Trp Gly Lys Ser Ser Val Ser Pro 
305                 310                 315                 320 


Ser Leu Glu Thr Trp Ala Thr Trp Leu Ser Phe Ala Ser Ala Val Cys 
                325                 330                 335     


His Pro Leu Ile Tyr Gly Leu Trp Asn Lys Thr Val Arg Lys Glu Leu 
            340                 345                 350         


Leu Gly Met Cys Phe Gly Asp Arg Tyr Tyr Arg Glu Pro Phe Val Gln 
        355                 360                 365             


Arg Gln Arg Thr Ser Arg Leu Phe Ser Ile Ser Asn Arg Ile Thr Asp 
    370                 375                 380                 


Leu Gly Leu Ser Pro His Leu Thr Ala Leu Met Ala Gly Gly Gln Pro 
385                 390                 395                 400 


Leu Gly His Ser Ser Ser Thr Gly Asp Thr Gly Phe Ser Cys Ser Gln 
                405                 410                 415     


Asp Ser Gly Thr Asp Met Met Leu Leu Glu Asp Tyr Thr Ser Asp Asp 
            420                 425                 430         


Asn Pro Pro Ser His Cys Thr Cys Pro Pro Lys Arg Arg Ser Ser Val 
        435                 440                 445             


Thr Phe Glu Asp Glu Val Glu Gln Ile Lys Glu Ala Ala Lys Asn Ser 
    450                 455                 460                 


Ile Leu His Val Lys Ala Glu Val His Lys Ser Leu Asp Ser Tyr Ala 
465                 470                 475                 480 


Ala Ser Leu Ala Lys Ala Ile Glu Ala Glu Ala Lys Ile Asn Leu Phe 
                485                 490                 495     


Gly Glu Glu Ala Leu Pro Gly Val Leu Val Thr Ala Arg Thr Val Pro 
            500                 505                 510         


Gly Gly Gly Phe Gly Gly Arg Arg Gly Ser Arg Thr Leu Val Ser Gln 
        515                 520                 525             


Arg Leu Gln Leu Gln Ser Ile Glu Glu Gly Asp Val Leu Ala Ala Glu 
    530                 535                 540                 


Gln Arg 
545     


<210>  4652
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR162__Homo_sapiens__NP_055264

<400>  4652

Met Leu Ser Thr Gly Val Val Ser Phe Phe Ser Leu Lys Ser Asp Ser 
1               5                   10                  15      


Ala Pro Pro Trp Met Val Leu Ala Val Leu Trp Cys Ser Met Ala Gln 
            20                  25                  30          


Thr Leu Leu Leu Pro Ser Phe Ile Trp Ser Cys Glu Arg Tyr Arg Ala 
        35                  40                  45              


Asp Val Arg Thr Val Trp Glu Gln Cys Val Ala Ile Met Ser Glu Glu 
    50                  55                  60                  


Asp Gly Asp Asp Asp Gly Gly Cys Asp Asp Tyr Ala Glu Gly Arg Val 
65                  70                  75                  80  


Cys Lys Val Arg Phe Asp Ala Asn Gly Ala Thr Gly Pro Gly Ser Arg 
                85                  90                  95      


Asp Pro Ala Gln Val Lys Leu Leu Pro Gly Arg His Met Leu Phe Pro 
            100                 105                 110         


Pro Leu Glu Arg Val His Tyr Leu Gln Val Pro Leu Ser Arg Arg Leu 
        115                 120                 125             


Ser His Asp Glu Thr Asn Ile Phe Ser Thr Pro Arg Glu Pro Gly Ser 
    130                 135                 140                 


Phe Leu His Lys Trp Ser Ser Ser Asp Asp Ile Arg Val Leu Pro Ala 
145                 150                 155                 160 


Gln Ser Arg Ala Leu Gly Gly Pro Pro Glu Tyr Leu Gly Gln Arg His 
                165                 170                 175     


Arg Leu Glu Asp Glu Glu Asp Glu Glu Glu Ala Glu Gly Gly Gly Leu 
            180                 185                 190         


Ala Ser Leu Arg Gln Phe Leu Glu Ser Gly Val Leu Gly Ser Gly Gly 
        195                 200                 205             


Gly Pro Pro Arg Gly Pro Gly Phe Phe Arg Glu Glu Ile Thr Thr Phe 
    210                 215                 220                 


Ile Asp Glu Thr Pro Leu Pro Ser Pro Thr Ala Ser Pro Gly His Ser 
225                 230                 235                 240 


Pro Arg Arg Pro Arg Pro Leu Gly Leu Ser Pro Arg Arg Leu Ser Leu 
                245                 250                 255     


Gly Ser Pro Glu Ser Arg Ala Val Gly Leu Pro Leu Gly Leu Ser Ala 
            260                 265                 270         


Gly Arg Arg Cys Ser Leu Thr Gly Gly Glu Glu Ser Ala Arg Ala Trp 
        275                 280                 285             


Gly Gly Ser Trp Gly Pro Gly Asn Pro Ile Phe Pro Gln Leu Thr Leu 
    290                 295                 300                 


<210>  4653
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR171__Homo_sapiens__NP_037440

<400>  4653

Met Thr Asn Ser Ser Phe Phe Cys Pro Val Tyr Lys Asp Leu Glu Pro 
1               5                   10                  15      


Phe Thr Tyr Phe Phe Tyr Leu Val Phe Leu Val Gly Ile Ile Gly Ser 
            20                  25                  30          


Cys Phe Ala Thr Trp Ala Phe Ile Gln Lys Asn Thr Asn His Arg Cys 
        35                  40                  45              


Val Ser Ile Tyr Leu Ile Asn Leu Leu Thr Ala Asp Phe Leu Leu Thr 
    50                  55                  60                  


Leu Ala Leu Pro Val Lys Ile Val Val Asp Leu Gly Val Ala Pro Trp 
65                  70                  75                  80  


Lys Leu Lys Ile Phe His Cys Gln Val Thr Ala Cys Leu Ile Tyr Ile 
                85                  90                  95      


Asn Met Tyr Leu Ser Ile Ile Phe Leu Ala Phe Val Ser Ile Asp Arg 
            100                 105                 110         


Cys Leu Gln Leu Thr His Ser Cys Lys Ile Tyr Arg Ile Gln Glu Pro 
        115                 120                 125             


Gly Phe Ala Lys Met Ile Ser Thr Val Val Trp Leu Met Val Leu Leu 
    130                 135                 140                 


Ile Met Val Pro Asn Met Met Ile Pro Ile Lys Asp Ile Lys Glu Lys 
145                 150                 155                 160 


Ser Asn Val Gly Cys Met Glu Phe Lys Lys Glu Phe Gly Arg Asn Trp 
                165                 170                 175     


His Leu Leu Thr Asn Phe Ile Cys Val Ala Ile Phe Leu Asn Phe Ser 
            180                 185                 190         


Ala Ile Ile Leu Ile Ser Asn Cys Leu Val Ile Arg Gln Leu Tyr Arg 
        195                 200                 205             


Asn Lys Asp Asn Glu Asn Tyr Pro Asn Val Lys Lys Ala Leu Ile Asn 
    210                 215                 220                 


Ile Leu Leu Val Thr Thr Gly Tyr Ile Ile Cys Phe Val Pro Tyr His 
225                 230                 235                 240 


Ile Val Arg Ile Pro Tyr Thr Leu Ser Gln Thr Glu Val Ile Thr Asp 
                245                 250                 255     


Cys Ser Thr Arg Ile Ser Leu Phe Lys Ala Lys Glu Ala Thr Leu Leu 
            260                 265                 270         


Leu Ala Val Ser Asn Leu Cys Phe Asp Pro Ile Leu Tyr Tyr His Leu 
        275                 280                 285             


Ser Lys Ala Phe Arg Ser Lys Val Thr Glu Thr Phe Ala Ser Pro Lys 
    290                 295                 300                 


Glu Thr Lys Ala Gln Lys Glu Lys Leu Arg Cys Glu Asn Asn Ala 
305                 310                 315                 


<210>  4654
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR174__Homo_sapiens__NP_115942

<400>  4654

Met Pro Ala Asn Tyr Thr Cys Thr Arg Pro Asp Gly Asp Asn Thr Asp 
1               5                   10                  15      


Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro 
            20                  25                  30          


Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met 
        35                  40                  45              


Lys Glu Thr Lys Arg Ala Val Ile Phe Met Ile Asn Leu Ala Ile Ala 
    50                  55                  60                  


Asp Leu Leu Gln Val Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu 
65                  70                  75                  80  


Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr 
                85                  90                  95      


Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile 
            100                 105                 110         


Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe His Asp 
        115                 120                 125             


Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ala Gly Trp Leu Ile 
    130                 135                 140                 


Ile Cys Leu Ala Cys Val Leu Phe Pro Leu Leu Arg Thr Ser Asp Asp 
145                 150                 155                 160 


Thr Ser Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Thr Arg Asn 
                165                 170                 175     


Val Asn Leu Ala Gln Ser Val Val Met Met Thr Ile Gly Glu Leu Ile 
            180                 185                 190         


Gly Phe Val Thr Pro Leu Leu Ile Val Leu Tyr Cys Thr Trp Lys Thr 
        195                 200                 205             


Val Leu Ser Leu Gln Asp Lys Tyr Pro Met Ala Gln Asp Leu Gly Glu 
    210                 215                 220                 


Lys Gln Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu 
225                 230                 235                 240 


Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val 
                245                 250                 255     


Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile 
            260                 265                 270         


Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp 
        275                 280                 285             


Pro Val Ile Tyr Tyr Phe Ser Thr Asn Glu Phe Arg Arg Arg Leu Ser 
    290                 295                 300                 


Arg Gln Asp Leu His Asp Ser Ile Gln Leu His Ala Lys Ser Phe Val 
305                 310                 315                 320 


Ser Asn His Thr Ala Ser Thr Met Thr Pro Glu Leu Cys 
                325                 330             


<210>  4655
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR176__Homo_sapiens__NP_001258784

<400>  4655

Met Pro Ala Pro Leu Leu Leu Ile Ser Arg Thr Leu Gly Asn Phe Met 
1               5                   10                  15      


Val Leu Trp Ser Thr Cys Arg Thr Thr Val Phe Lys Ser Val Thr Asn 
            20                  25                  30          


Arg Phe Ile Lys Asn Leu Ala Cys Ser Gly Ile Cys Ala Ser Leu Val 
        35                  40                  45              


Cys Val Pro Phe Asp Ile Ile Leu Ser Thr Ser Pro His Cys Cys Trp 
    50                  55                  60                  


Trp Ile Tyr Thr Met Leu Phe Cys Lys Val Val Lys Phe Leu His Lys 
65                  70                  75                  80  


Val Phe Cys Ser Val Thr Ile Leu Ser Phe Pro Ala Ile Ala Leu Asp 
                85                  90                  95      


Arg Tyr Tyr Ser Val Leu Tyr Pro Leu Glu Arg Lys Ile Ser Asp Ala 
            100                 105                 110         


Lys Ser Arg Glu Leu Val Met Tyr Ile Trp Ala His Ala Val Val Ala 
        115                 120                 125             


Ser Val Pro Val Phe Ala Val Thr Asn Val Ala Asp Ile Tyr Ala Thr 
    130                 135                 140                 


Ser Thr Cys Thr Glu Val Trp Ser Asn Ser Leu Gly His Leu Val Tyr 
145                 150                 155                 160 


Val Leu Val Tyr Asn Ile Thr Thr Val Ile Val Pro Val Val Val Val 
                165                 170                 175     


Phe Leu Phe Leu Ile Leu Ile Arg Arg Ala Leu Ser Ala Ser Gln Lys 
            180                 185                 190         


Lys Lys Val Ile Ile Ala Ala Leu Arg Thr Pro Gln Asn Thr Ile Ser 
        195                 200                 205             


Ile Pro Tyr Ala Ser Gln Arg Glu Ala Glu Leu His Ala Thr Leu Leu 
    210                 215                 220                 


Ser Met Val Met Val Phe Ile Leu Cys Ser Val Pro Tyr Ala Thr Leu 
225                 230                 235                 240 


Val Val Tyr Gln Thr Val Leu Asn Val Pro Asp Thr Ser Val Phe Leu 
                245                 250                 255     


Leu Leu Thr Ala Val Trp Leu Pro Lys Val Ser Leu Leu Ala Asn Pro 
            260                 265                 270         


Val Leu Phe Leu Thr Val Asn Lys Ser Val Arg Lys Cys Leu Ile Gly 
        275                 280                 285             


Thr Leu Val Gln Leu His His Arg Tyr Ser Arg Arg Asn Val Val Ser 
    290                 295                 300                 


Thr Gly Ser Gly Met Ala Glu Ala Ser Leu Glu Pro Ser Ile Arg Ser 
305                 310                 315                 320 


Gly Ser Gln Leu Leu Glu Met Phe His Ile Gly Gln Gln Gln Ile Phe 
                325                 330                 335     


Lys Pro Thr Glu Asp Glu Glu Glu Ser Glu Ala Lys Tyr Ile Gly Ser 
            340                 345                 350         


Ala Asp Phe Gln Ala Lys Glu Ile Phe Ser Thr Cys Leu Glu Gly Glu 
        355                 360                 365             


Gln Gly Pro Gln Phe Ala Pro Ser Ala Pro Pro Leu Ser Thr Val Asp 
    370                 375                 380                 


Ser Val Ser Gln Val Ala Pro Ala Ala Pro Val Glu Pro Glu Thr Phe 
385                 390                 395                 400 


Pro Asp Lys Tyr Ser Leu Gln Phe Gly Phe Gly Pro Phe Glu Leu Pro 
                405                 410                 415     


Pro Gln Trp Leu Ser Glu Thr Arg Asn Ser Lys Lys Arg Leu Leu Pro 
            420                 425                 430         


Pro Leu Gly Asn Thr Pro Glu Glu Leu Ile Gln Thr Lys Val Pro Lys 
        435                 440                 445             


Val Gly Arg Val Glu Arg Lys Met Ser Arg Asn Asn Lys Val Ser Ile 
    450                 455                 460                 


Phe Pro Lys Val Asp Ser 
465                 470 


<210>  4656
<211>  2367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR179__Homo_sapiens__NP_001004334

<400>  4656

Met Gly Thr Arg Gly Ala Val Met Pro Pro Pro Met Trp Gly Leu Leu 
1               5                   10                  15      


Gly Cys Cys Phe Val Cys Ala Trp Ala Leu Gly Gly Pro Arg Pro Ile 
            20                  25                  30          


Arg Ser Leu Pro Pro Leu Ser Ser Gln Val Lys Pro Gly Ser Val Pro 
        35                  40                  45              


Met Gln Val Pro Leu Glu Gly Ala Glu Ala Ala Leu Ala Tyr Leu Tyr 
    50                  55                  60                  


Ser Gly Asp Ala Gln Gln Leu Ser Gln Val Asn Cys Ser Glu Arg Tyr 
65                  70                  75                  80  


Glu Ala Arg Gly Ala Gly Ala Met Pro Gly Leu Pro Pro Ser Leu Gln 
                85                  90                  95      


Gly Ala Ala Gly Thr Leu Ala Gln Ala Ala Asn Phe Leu Asn Met Leu 
            100                 105                 110         


Leu Gln Ala Asn Asp Ile Arg Glu Ser Ser Val Glu Glu Asp Val Glu 
        115                 120                 125             


Trp Tyr Gln Ala Leu Val Arg Ser Val Ala Glu Gly Asp Pro Arg Val 
    130                 135                 140                 


Tyr Arg Ala Leu Leu Thr Phe Asn Pro Pro Pro Gly Ala Ser His Leu 
145                 150                 155                 160 


Gln Leu Ala Leu Gln Ala Thr Arg Thr Gly Glu Glu Thr Ile Leu Gln 
                165                 170                 175     


Asp Leu Ser Gly Asn Trp Val Gln Glu Glu Asn Pro Pro Gly Asp Leu 
            180                 185                 190         


Asp Thr Pro Ala Leu Lys Lys Arg Val Leu Thr Asn Asp Leu Gly Ser 
        195                 200                 205             


Leu Gly Ser Pro Lys Trp Pro Gln Ala Asp Gly Tyr Val Gly Asp Thr 
    210                 215                 220                 


Gln Gln Val Arg Leu Ser Pro Pro Phe Leu Glu Cys Gln Glu Gly Arg 
225                 230                 235                 240 


Leu Arg Pro Gly Trp Leu Ile Thr Leu Ser Ala Thr Phe Tyr Gly Leu 
                245                 250                 255     


Lys Pro Asp Leu Ser Pro Glu Val Arg Gly Gln Val Gln Met Asp Val 
            260                 265                 270         


Asp Leu Gln Ser Val Asp Ile Asn Gln Cys Ala Ser Gly Pro Gly Trp 
        275                 280                 285             


Tyr Ser Asn Thr His Leu Cys Asp Leu Asn Ser Thr Gln Cys Val Pro 
    290                 295                 300                 


Leu Glu Ser Gln Gly Phe Val Leu Gly Arg Tyr Leu Cys Arg Cys Arg 
305                 310                 315                 320 


Pro Gly Phe Tyr Gly Ala Ser Pro Ser Gly Gly Leu Glu Glu Ser Asp 
                325                 330                 335     


Phe Gln Thr Thr Gly Gln Phe Gly Phe Pro Glu Gly Arg Ser Gly Arg 
            340                 345                 350         


Leu Leu Gln Cys Leu Pro Cys Pro Glu Gly Cys Thr Ser Cys Met Asp 
        355                 360                 365             


Ala Thr Pro Cys Leu Val Glu Glu Ala Ala Val Leu Arg Ala Ala Val 
    370                 375                 380                 


Leu Ala Cys Gln Ala Cys Cys Met Leu Ala Ile Phe Leu Ser Met Leu 
385                 390                 395                 400 


Val Ser Tyr Arg Cys Arg Arg Asn Lys Arg Ile Trp Ala Ser Gly Val 
                405                 410                 415     


Val Leu Leu Glu Thr Val Leu Phe Gly Phe Leu Leu Leu Tyr Phe Pro 
            420                 425                 430         


Val Phe Ile Leu Tyr Phe Lys Pro Ser Val Phe Arg Cys Ile Ala Leu 
        435                 440                 445             


Arg Trp Val Arg Leu Leu Gly Phe Ala Ile Val Tyr Gly Thr Ile Ile 
    450                 455                 460                 


Leu Lys Leu Tyr Arg Val Leu Gln Leu Phe Leu Ser Arg Thr Ala Gln 
465                 470                 475                 480 


Arg Ser Ala Leu Leu Ser Ser Gly Arg Leu Leu Arg His Leu Gly Leu 
                485                 490                 495     


Leu Leu Leu Pro Val Leu Gly Phe Leu Ala Val Trp Thr Val Gly Ala 
            500                 505                 510         


Leu Glu Arg Gly Ile Gln His Ala Pro Leu Val Ile Arg Gly His Thr 
        515                 520                 525             


Pro Ser Gly Arg His Phe Tyr Leu Cys His His Asp Arg Trp Asp Tyr 
    530                 535                 540                 


Ile Met Val Val Ala Glu Leu Leu Leu Leu Cys Trp Gly Ser Phe Leu 
545                 550                 555                 560 


Cys Tyr Ala Thr Arg Ala Val Leu Ser Ala Phe His Glu Pro Arg Tyr 
                565                 570                 575     


Met Gly Ile Ala Leu His Asn Glu Leu Leu Leu Ser Ala Ala Phe His 
            580                 585                 590         


Thr Ala Arg Phe Val Leu Val Pro Ser Leu His Pro Asp Trp Thr Leu 
        595                 600                 605             


Leu Leu Phe Phe Phe His Thr His Ser Thr Val Thr Thr Thr Leu Ala 
    610                 615                 620                 


Leu Ile Phe Ile Pro Lys Phe Trp Lys Leu Gly Ala Pro Pro Arg Glu 
625                 630                 635                 640 


Glu Met Val Asp Glu Val Cys Glu Asp Glu Leu Asp Leu Gln His Ser 
                645                 650                 655     


Gly Ser Tyr Leu Gly Ser Ser Ile Ala Ser Ala Trp Ser Glu His Ser 
            660                 665                 670         


Leu Asp Pro Gly Asp Ile Arg Asp Glu Leu Lys Lys Leu Tyr Ala Gln 
        675                 680                 685             


Leu Glu Val His Lys Thr Lys Glu Met Ala Ala Asn Asn Pro His Leu 
    690                 695                 700                 


Pro Lys Lys Arg Gly Ser Ser Cys Gln Gly Leu Gly Arg Ser Phe Met 
705                 710                 715                 720 


Arg Tyr Leu Ala Glu Phe Pro Glu Ala Leu Ala Arg Gln His Ser Arg 
                725                 730                 735     


Asp Ser Gly Ser Pro Gly His Gly Ser Leu Pro Gly Ser Ser Arg Arg 
            740                 745                 750         


Arg Leu Leu Ser Ser Ser Leu Gln Glu Pro Glu Gly Thr Pro Ala Leu 
        755                 760                 765             


His Lys Ser Arg Ser Thr Tyr Asp Gln Arg Arg Glu Gln Asp Pro Pro 
    770                 775                 780                 


Leu Leu Asp Ser Leu Leu Arg Arg Lys Leu Ala Lys Lys Ala Ser Arg 
785                 790                 795                 800 


Thr Glu Ser Arg Glu Ser Val Glu Gly Pro Pro Ala Leu Gly Phe Arg 
                805                 810                 815     


Ser Ala Ser Ala His Asn Leu Thr Val Gly Glu Arg Leu Pro Arg Ala 
            820                 825                 830         


Arg Pro Ala Ser Leu Gln Lys Ser Leu Ser Val Ala Ser Ser Arg Glu 
        835                 840                 845             


Lys Ala Leu Leu Met Ala Ser Gln Ala Tyr Leu Glu Glu Thr Tyr Arg 
    850                 855                 860                 


Gln Ala Lys Glu Arg Glu Glu Arg Lys Lys Ala Lys Ala Ala Met Ala 
865                 870                 875                 880 


Ser Leu Val Arg Arg Pro Ser Ala Arg Arg Leu Glu Arg Pro Arg Gly 
                885                 890                 895     


Ala Pro Leu Ser Ala Pro Pro Ser Pro Ala Lys Ser Ser Ser Val Asp 
            900                 905                 910         


Ser Ser His Thr Ser Gly Arg Leu His Glu Glu Ala Arg Arg Arg Leu 
        915                 920                 925             


Pro His Pro Pro Ile Arg His Gln Val Ser Thr Pro Ile Leu Ala Leu 
    930                 935                 940                 


Ser Gly Gly Leu Gly Glu Pro Arg Met Leu Ser Pro Thr Ser Thr Leu 
945                 950                 955                 960 


Ala Pro Ala Leu Leu Pro Ala Leu Ala Pro Thr Pro Ala Pro Ala Leu 
                965                 970                 975     


Ala Pro Val Pro Val Ser Pro Gln Ser Pro Asn Leu Leu Thr Tyr Ile 
            980                 985                 990         


Cys Pro Trp Glu Asn Ala Glu Leu  Pro Ala Lys Gln Glu  Asn Val Pro 
        995                 1000                 1005             


Gln Glu  Gly Pro Ser Gly Pro  Glu Arg Gly His His  Ser Pro Ala 
    1010                 1015                 1020             


Pro Ala  Arg Ala Arg Leu Trp  Arg Ala Leu Ser Val  Ala Val Glu 
    1025                 1030                 1035             


Lys Ser  Arg Ala Gly Glu Asn  Glu Met Asp Ala Glu  Asp Ala His 
    1040                 1045                 1050             


His Gln  Arg Glu Ala Asn Asp  Val Asp Glu Asp Arg  Pro Lys Ile 
    1055                 1060                 1065             


Phe Pro  Lys Ser His Ser Leu  Lys Ala Pro Val Gln  Gln Gly Ser 
    1070                 1075                 1080             


Met Arg  Ser Leu Gly Leu Ala  Ile Lys Ala Leu Thr  Arg Ser Arg 
    1085                 1090                 1095             


Ser Thr  Tyr Arg Glu Lys Glu  Ser Val Glu Glu Ser  Pro Glu Gly 
    1100                 1105                 1110             


Gln Asn  Ser Gly Thr Ala Gly  Glu Ser Met Gly Ala  Pro Ser Arg 
    1115                 1120                 1125             


Ser Pro  Arg Leu Gly Arg Pro  Lys Ala Val Ser Lys  Gln Ala Ala 
    1130                 1135                 1140             


Leu Ile  Pro Ser Asp Asp Lys  Glu Ser Leu Gln Asn  Gln Gln Asn 
    1145                 1150                 1155             


Ala His  Thr Ser Arg Met Leu  Gln Val Cys Gln Arg  Glu Gly Ser 
    1160                 1165                 1170             


Arg Glu  Gln Glu Asp Arg Gly  Arg Arg Met Thr Gln  Gly Leu Gly 
    1175                 1180                 1185             


Glu Arg  Lys Ala Glu Arg Ala  Gly Lys Thr Gly Leu  Ala Met Leu 
    1190                 1195                 1200             


Arg Gln  Val Ser Arg Asp Lys  Asn Ile Lys Gln Ser  Lys Glu Thr 
    1205                 1210                 1215             


Pro Val  Gly Trp Gln Glu Leu  Pro Lys Ala Gly Leu  Gln Ser Leu 
    1220                 1225                 1230             


Gly Ser  Ala Asp His Arg Val  Ala Glu Val Cys Pro  Trp Glu Val 
    1235                 1240                 1245             


Thr Glu  Ser Glu Thr Arg Gln  Pro Asp Ser Gly Asn  Lys Ala Glu 
    1250                 1255                 1260             


Ile Cys  Pro Trp Glu Thr Ser  Glu Gly Ala Pro Glu  Ser Arg Ala 
    1265                 1270                 1275             


Leu Arg  Gln Asp Pro Gly Asp  Ser Gln Lys Lys Arg  Gly Glu Ala 
    1280                 1285                 1290             


Arg Gly  Lys Ser Glu Pro Ile  Asp Val Val Pro Met  Met Arg Lys 
    1295                 1300                 1305             


Lys Pro  Glu Arg Leu Val Arg  Glu Gln Glu Ala Val  Cys Pro Trp 
    1310                 1315                 1320             


Glu Ser  Ala Asp Arg Gly Gly  Leu Ser Pro Gly Ser  Ala Pro Gln 
    1325                 1330                 1335             


Asp Pro  Gly Arg Ile Arg Asp  Lys Ser Glu Ala Gly  Asp Ser Val 
    1340                 1345                 1350             


Glu Ala  Arg Lys Val Glu Lys  Pro Gly Trp Glu Ala  Ala Gly Pro 
    1355                 1360                 1365             


Glu Ala  His Thr Pro Asp Ile  Thr Lys Ala Glu Pro  Cys Pro Trp 
    1370                 1375                 1380             


Glu Ala  Ser Glu Gly Gly Glu  Asp Gly Lys Pro Ala  Gln Glu Ala 
    1385                 1390                 1395             


Val Lys  Asp Leu Pro Gln Glu  Lys Gln Lys Thr Arg  Lys Ala Thr 
    1400                 1405                 1410             


Phe Trp  Lys Glu Gln Lys Pro  Gly Gly Asp Leu Glu  Ser Leu Cys 
    1415                 1420                 1425             


Pro Trp  Glu Ser Thr Asp Phe  Arg Gly Pro Ser Ala  Val Ser Ile 
    1430                 1435                 1440             


Gln Ala  Pro Gly Ser Ser Glu  Cys Ser Gly Ser Leu  Gly Ser Gly 
    1445                 1450                 1455             


Ile Ala  Glu Val Cys Leu Trp  Glu Ala Gly Asp Ala  Pro Ala Ile 
    1460                 1465                 1470             


Gln Lys  Ala Glu Ile Cys Pro  Trp Glu Leu Asp Asp  Asn Val Met 
    1475                 1480                 1485             


Gly Gln  Glu Met Leu Ser Leu  Gly Thr Gly Arg Glu  Ser Leu Gln 
    1490                 1495                 1500             


Glu Lys  Glu Lys Ala Ser Arg  Lys Gly Ser Phe Gly  Glu Met Gly 
    1505                 1510                 1515             


Glu Gln  Thr Val Lys Ala Val  Gln Lys Leu Ser Gln  Gln Gln Glu 
    1520                 1525                 1530             


Ser Val  Cys Pro Arg Glu Ser  Thr Val Pro Gly His  Ser Ser Pro 
    1535                 1540                 1545             


Cys Leu  Asp Asn Ser Ser Ser  Lys Ala Gly Ser Gln  Phe Leu Cys 
    1550                 1555                 1560             


Asn Gly  Gly Ser Arg Ala Thr  Gln Val Cys Pro Gln  Glu Asp Leu 
    1565                 1570                 1575             


Arg Pro  Glu Ala Gln Glu Ala  Thr Pro Ala Lys Thr  Glu Ile Cys 
    1580                 1585                 1590             


Pro Trp  Glu Val Asn Glu Arg  Thr Arg Glu Glu Trp  Thr Ser Ala 
    1595                 1600                 1605             


Gln Val  Pro Arg Gly Gly Glu  Ser Gln Lys Asp Lys  Glu Lys Met 
    1610                 1615                 1620             


Pro Gly  Lys Ser Glu Ile Glu  Asp Val Thr Ala Trp  Glu Lys Pro 
    1625                 1630                 1635             


Glu Gly  Gln Ile Gln Lys Gln  Glu Ala Val Gly Pro  Trp Glu Ser 
    1640                 1645                 1650             


Val Asp  Pro Gly Ser Phe Ser  Pro Gln Pro Arg Pro  Gln Asp Thr 
    1655                 1660                 1665             


Glu Arg  Pro Gln Thr Leu Leu  Gln Met Ser Gly Ser  Val Gly Ser 
    1670                 1675                 1680             


Lys Ala  Ala Asp Ile Cys Pro  Leu Asp Val Glu Glu  Asn Leu Thr 
    1685                 1690                 1695             


Ala Gly  Lys Ala Glu Ile Cys  Pro Trp Glu Val Gly  Ala Gly Ala 
    1700                 1705                 1710             


Gly Glu  Glu Arg Ala Leu Gly  Ala Glu Ala Ile Arg  Lys Ser Pro 
    1715                 1720                 1725             


Asn Asp  Thr Gly Lys Val Ser  Ala Asp Leu Gly Pro  Arg Glu Arg 
    1730                 1735                 1740             


Ala Val  Thr Ala Pro Glu Lys  Pro Gln Lys Pro Thr  Pro Glu Trp 
    1745                 1750                 1755             


Glu Val  Ala Cys Pro Trp Gly  Ser Val Gly Pro Gly  Ala Cys Ser 
    1760                 1765                 1770             


Gln His  Pro Gly Thr Leu Asp  Ala Asp Gly Pro Lys  Ala Gly Phe 
    1775                 1780                 1785             


Gln Glu  Leu Asp His Met Gly  Cys Arg Pro Gly Glu  Val Cys Pro 
    1790                 1795                 1800             


Trp Glu  Ala Gln Glu Ala Ala  Thr Ser Glu Lys Ala  Lys Ile Cys 
    1805                 1810                 1815             


Pro Trp  Glu Val Ser Glu Gly  Thr Thr Gly Lys Gly  Leu Asp Gln 
    1820                 1825                 1830             


Lys Ala  Gly Ser Glu Ser Ala  Glu Gln Arg Glu Lys  Ala Leu Glu 
    1835                 1840                 1845             


Lys Gly  Arg Leu Thr Ser Leu  Gly Glu Asp Val Ser  Lys Gly Met 
    1850                 1855                 1860             


Ala Lys  Leu Cys Gln Gln Gln  Glu Thr Ile Cys Ile  Trp Glu Asn 
    1865                 1870                 1875             


Lys Asp  Leu Arg Glu Ser Pro  Ala Gln Ala Pro Lys  Ile Ser Asp 
    1880                 1885                 1890             


Leu Pro  Ser Ser Met Ser Ser  Glu Val Ala Glu Gly  His Ser Leu 
    1895                 1900                 1905             


Glu Ala  Thr Glu Lys Gly Asp  Leu Arg Gln Asp Pro  Lys Thr Gly 
    1910                 1915                 1920             


Ser Phe  Pro Glu His Ile Thr  Gln Glu Lys Ala Pro  Ala Ala Asp 
    1925                 1930                 1935             


Thr Glu  Glu Phe Thr Thr Glu  Asp Gly Glu Lys Thr  Ser His Glu 
    1940                 1945                 1950             


Leu Gln  Ser Val Cys Pro Trp  Glu Thr Thr Ala Pro  Ala Asp Ser 
    1955                 1960                 1965             


Val Ser  His Leu Asp Arg Gln  Arg Pro Asp Gln Pro  Lys Ala Ser 
    1970                 1975                 1980             


Ser Gln  Arg Leu Val Ser Thr  Gly Gly Arg Ala Ala  Asp Val Cys 
    1985                 1990                 1995             


Pro Trp  Asp Val Pro Asp Ala  Gly Val Tyr Lys Ser  Asp Ser Ser 
    2000                 2005                 2010             


Ala Lys  Ala Glu Thr Cys Pro  Trp Glu Val Thr Glu  Arg Ile Pro 
    2015                 2020                 2025             


Val Lys  Gly Val Ser Arg Gln  Asp Gly Lys Gly Asp  Ser Gln Glu 
    2030                 2035                 2040             


Glu Lys  Gly Arg Ala Pro Glu  Lys Ser Glu Pro Lys  Gly Val Pro 
    2045                 2050                 2055             


Val Gln  Lys Lys Pro Glu Met  Ala Asp Phe Arg Gln  Gln Glu Ala 
    2060                 2065                 2070             


Val Cys  Pro Trp Glu Ser Gln  Asp Gly Lys Gly Leu  Ser Pro Gln 
    2075                 2080                 2085             


Pro Ala  Pro Asp Ala Ser Asp  Arg Ser Arg Gly Ser  Ser Glu Ala 
    2090                 2095                 2100             


Ala Gly  Ser Val Glu Thr Arg  Val Ala Glu Val Cys  Leu Trp Glu 
    2105                 2110                 2115             


Val Val  Glu Ala Pro Ser Ala  Lys Lys Ala Glu Ile  Cys Pro Trp 
    2120                 2125                 2130             


Glu Ala  Gly Gly Gly Ala Ala  Glu Glu Gly Glu Gln  Glu Arg Glu 
    2135                 2140                 2145             


Ser Gln  Gly Gln Gly Glu Met  Phe Leu Gln Lys Ala  Gly Pro Gly 
    2150                 2155                 2160             


Gly Thr  Glu Glu His Phe Ser  Lys Ala Ala Ala Lys  Pro Arg Glu 
    2165                 2170                 2175             


Gln Glu  Ala Val Cys Pro Gly  Glu Gly Thr Gly Ser  Gly Gly Leu 
    2180                 2185                 2190             


Leu Pro  Gln Ser Gly Ala Leu  Asp Pro Glu Leu Lys  Val Ser Pro 
    2195                 2200                 2205             


Lys Glu  Ala Gly Ser Met Gly  Ser Arg Met Ala Glu  Leu Cys Gln 
    2210                 2215                 2220             


Trp Glu  Ile Thr Asp Pro Glu  Gly Asn Lys Ile Lys  Gly Thr Met 
    2225                 2230                 2235             


Ala Asp  Ile Cys Pro Gly Glu  Glu Thr Gly Val Pro  Ser Glu Glu 
    2240                 2245                 2250             


Ser Gly  Leu Leu Ala Leu Thr  Ala Thr Arg Arg Glu  Phe Phe Pro 
    2255                 2260                 2265             


Thr Ala  Pro Glu Lys Pro Leu  Cys Leu Leu Val His  Gly Pro Leu 
    2270                 2275                 2280             


Asp His  Phe Phe Pro Glu Ser  Lys Ile Pro Cys Pro  Lys Val Ser 
    2285                 2290                 2295             


Arg Pro  Ala Ser Thr Phe Thr  Leu Glu Gly Val Arg  Glu Leu Gln 
    2300                 2305                 2310             


Gly Pro  Ser Gly Leu Glu Pro  Arg Thr Ser Leu Ala  Pro Glu Pro 
    2315                 2320                 2325             


Ser Leu  Gln Glu Ala Glu Ser  Gln Ser Ser Ser Leu  Thr Glu Asp 
    2330                 2335                 2340             


Ser Gly  Gln Val Ala Phe Glu  Ala Gln Tyr Glu Glu  Phe Thr Pro 
    2345                 2350                 2355             


Pro Thr  Val Tyr Pro Trp Asp  Trp Glu 
    2360                 2365         


<210>  4657
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR17__Homo_sapiens__NP_001154889

<400>  4657

Met Asn Gly Leu Glu Val Ala Pro Pro Gly Leu Ile Thr Asn Phe Ser 
1               5                   10                  15      


Leu Ala Thr Ala Glu Gln Cys Gly Gln Glu Thr Pro Leu Glu Asn Met 
            20                  25                  30          


Leu Phe Ala Ser Phe Tyr Leu Leu Asp Phe Ile Leu Ala Leu Val Gly 
        35                  40                  45              


Asn Thr Leu Ala Leu Trp Leu Phe Ile Arg Asp His Lys Ser Gly Thr 
    50                  55                  60                  


Pro Ala Asn Val Phe Leu Met His Leu Ala Val Ala Asp Leu Ser Cys 
65                  70                  75                  80  


Val Leu Val Leu Pro Thr Arg Leu Val Tyr His Phe Ser Gly Asn His 
                85                  90                  95      


Trp Pro Phe Gly Glu Ile Ala Cys Arg Leu Thr Gly Phe Leu Phe Tyr 
            100                 105                 110         


Leu Asn Met Tyr Ala Ser Ile Tyr Phe Leu Thr Cys Ile Ser Ala Asp 
        115                 120                 125             


Arg Phe Leu Ala Ile Val His Pro Val Lys Ser Leu Lys Leu Arg Arg 
    130                 135                 140                 


Pro Leu Tyr Ala His Leu Ala Cys Ala Phe Leu Trp Val Val Val Ala 
145                 150                 155                 160 


Val Ala Met Ala Pro Leu Leu Val Ser Pro Gln Thr Val Gln Thr Asn 
                165                 170                 175     


His Thr Val Val Cys Leu Gln Leu Tyr Arg Glu Lys Ala Ser His His 
            180                 185                 190         


Ala Leu Val Ser Leu Ala Val Ala Phe Thr Phe Pro Phe Ile Thr Thr 
        195                 200                 205             


Val Thr Cys Tyr Leu Leu Ile Ile Arg Ser Leu Arg Gln Gly Leu Arg 
    210                 215                 220                 


Val Glu Lys Arg Leu Lys Thr Lys Ala Val Arg Met Ile Ala Ile Val 
225                 230                 235                 240 


Leu Ala Ile Phe Leu Val Cys Phe Val Pro Tyr His Val Asn Arg Ser 
                245                 250                 255     


Val Tyr Val Leu His Tyr Arg Ser His Gly Ala Ser Cys Ala Thr Gln 
            260                 265                 270         


Arg Ile Leu Ala Leu Ala Asn Arg Ile Thr Ser Cys Leu Thr Ser Leu 
        275                 280                 285             


Asn Gly Ala Leu Asp Pro Ile Met Tyr Phe Phe Val Ala Glu Lys Phe 
    290                 295                 300                 


Arg His Ala Leu Cys Asn Leu Leu Cys Gly Lys Arg Leu Lys Gly Pro 
305                 310                 315                 320 


Pro Pro Ser Phe Glu Gly Lys Thr Asn Glu Ser Ser Leu Ser Ala Lys 
                325                 330                 335     


Ser Glu Leu 
            


<210>  4658
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR180__Homo_sapiens__NP_851320

<400>  4658

Met Gly Gly Leu Arg Leu Leu Ala Val Ala Leu Thr Cys Cys Trp Trp 
1               5                   10                  15      


Pro Gln Gly Ser Gln Gly Lys Thr Leu Arg Gly Ser Phe Ser Ser Thr 
            20                  25                  30          


Ala Ala Gln Asp Ala Gln Gly Gln Arg Ile Gly His Phe Glu Phe His 
        35                  40                  45              


Gly Asp His Ala Leu Leu Cys Val Arg Ile Asn Asn Ile Ala Val Ala 
    50                  55                  60                  


Val Gly Lys Glu Ala Lys Leu Tyr Leu Phe Gln Ala Gln Glu Trp Leu 
65                  70                  75                  80  


Lys Leu Gln Gln Ser Ser His Gly Tyr Ser Cys Ser Glu Lys Leu Ser 
                85                  90                  95      


Lys Ala Gln Leu Thr Met Thr Met Asn Gln Thr Glu His Asn Leu Thr 
            100                 105                 110         


Val Ser Gln Ile Pro Ser Pro Gln Thr Trp His Val Phe Tyr Ala Asp 
        115                 120                 125             


Lys Tyr Thr Cys Gln Asp Asp Lys Glu Asn Ser Gln Val Glu Asp Ile 
    130                 135                 140                 


Pro Phe Glu Met Val Leu Leu Asn Pro Asp Ala Glu Gly Asn Pro Phe 
145                 150                 155                 160 


Asp His Phe Ser Ala Gly Glu Ser Gly Leu His Glu Phe Phe Phe Leu 
                165                 170                 175     


Leu Val Leu Val Tyr Phe Val Ile Ala Cys Ile Tyr Ala Gln Ser Leu 
            180                 185                 190         


Trp Gln Ala Ile Lys Lys Gly Gly Pro Met His Met Ile Leu Lys Val 
        195                 200                 205             


Leu Thr Thr Ala Leu Leu Leu Gln Ala Gly Ser Ala Leu Ala Asn Tyr 
    210                 215                 220                 


Ile His Phe Ser Ser Tyr Ser Lys Asp Gly Ile Gly Val Pro Phe Met 
225                 230                 235                 240 


Gly Ser Leu Ala Glu Phe Phe Asp Ile Ala Ser Gln Ile Gln Met Leu 
                245                 250                 255     


Tyr Leu Leu Leu Ser Leu Cys Met Gly Trp Thr Ile Val Arg Met Lys 
            260                 265                 270         


Lys Ser Gln Ser Arg Pro Leu Gln Trp Asp Ser Thr Pro Ala Ser Thr 
        275                 280                 285             


Gly Ile Ala Val Phe Ile Val Met Thr Gln Ser Val Leu Leu Leu Trp 
    290                 295                 300                 


Glu Gln Phe Glu Asp Ile Ser His His Ser Tyr His Ser His His Asn 
305                 310                 315                 320 


Leu Ala Gly Ile Leu Leu Ile Val Leu Arg Ile Cys Leu Ala Leu Ser 
                325                 330                 335     


Leu Gly Cys Gly Leu Tyr Gln Ile Ile Thr Val Glu Arg Ser Thr Leu 
            340                 345                 350         


Lys Arg Glu Phe Tyr Ile Thr Phe Ala Lys Gly Cys Ile Leu Trp Phe 
        355                 360                 365             


Leu Cys His Pro Val Leu Ala Cys Ile Ser Val Ile Phe Ser Asp Tyr 
    370                 375                 380                 


Gln Arg Asp Lys Val Ile Thr Ile Gly Val Ile Leu Cys Gln Ser Val 
385                 390                 395                 400 


Ser Met Val Ile Leu Tyr Arg Leu Phe Leu Ser His Ser Leu Tyr Trp 
                405                 410                 415     


Glu Val Ser Ser Leu Ser Ser Val Thr Leu Pro Leu Thr Ile Ser Ser 
            420                 425                 430         


Gly His Lys Ser Arg Pro His Phe 
        435                 440 


<210>  4659
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR182__Homo_sapiens__XP_011536129

<400>  4659

Met Ser Val Lys Pro Ser Trp Gly Pro Gly Pro Ser Glu Gly Val Thr 
1               5                   10                  15      


Ala Val Pro Thr Ser Asp Leu Gly Glu Ile His Asn Trp Thr Glu Leu 
            20                  25                  30          


Leu Asp Leu Phe Asn His Thr Leu Ser Glu Cys His Val Glu Leu Ser 
        35                  40                  45              


Gln Ser Thr Lys Arg Val Val Leu Phe Ala Leu Tyr Leu Ala Met Phe 
    50                  55                  60                  


Val Val Gly Leu Val Glu Asn Leu Leu Val Ile Cys Val Asn Trp Arg 
65                  70                  75                  80  


Gly Ser Gly Arg Ala Gly Leu Met Asn Leu Tyr Ile Leu Asn Met Ala 
                85                  90                  95      


Ile Ala Asp Leu Gly Ile Val Leu Ser Leu Pro Val Trp Met Leu Glu 
            100                 105                 110         


Val Thr Leu Asp Tyr Thr Trp Leu Trp Gly Ser Phe Ser Cys Arg Phe 
        115                 120                 125             


Thr His Tyr Phe Tyr Phe Val Asn Met Tyr Ser Ser Ile Phe Phe Leu 
    130                 135                 140                 


Val Cys Leu Ser Val Asp Arg Tyr Val Thr Leu Thr Ser Ala Ser Pro 
145                 150                 155                 160 


Ser Trp Gln Arg Tyr Gln His Arg Val Arg Arg Ala Met Cys Ala Gly 
                165                 170                 175     


Ile Trp Val Leu Ser Ala Ile Ile Pro Leu Pro Glu Val Val His Ile 
            180                 185                 190         


Gln Leu Val Glu Gly Pro Glu Pro Met Cys Leu Phe Met Ala Pro Phe 
        195                 200                 205             


Glu Thr Tyr Ser Thr Trp Ala Leu Ala Val Ala Leu Ser Thr Thr Ile 
    210                 215                 220                 


Leu Gly Phe Leu Leu Pro Phe Pro Leu Ile Thr Val Phe Asn Val Leu 
225                 230                 235                 240 


Thr Ala Cys Arg Leu Arg Gln Pro Gly Gln Pro Lys Ser Arg Arg His 
                245                 250                 255     


Cys Leu Leu Leu Cys Ala Tyr Val Ala Val Phe Val Met Cys Trp Leu 
            260                 265                 270         


Pro Tyr His Val Thr Leu Leu Leu Leu Thr Leu His Gly Thr His Ile 
        275                 280                 285             


Ser Leu His Cys His Leu Val His Leu Leu Tyr Phe Phe Tyr Asp Val 
    290                 295                 300                 


Ile Asp Cys Phe Ser Met Leu His Cys Val Ile Asn Pro Ile Leu Tyr 
305                 310                 315                 320 


Asn Phe Leu Ser Pro His Phe Arg Gly Arg Leu Leu Asn Ala Val Val 
                325                 330                 335     


His Tyr Leu Pro Lys Asp Gln Thr Lys Ala Gly Thr Cys Ala Ser Ser 
            340                 345                 350         


Ser Ser Cys Ser Thr Gln His Ser Ile Ile Ile Thr Lys Gly Asp Ser 
        355                 360                 365             


Gln Pro Ala Ala Ala Ala Pro His Pro Glu Pro Ser Leu Ser Phe Gln 
    370                 375                 380                 


Ala His His Leu Leu Pro Asn Thr Ser Pro Ile Ser Pro Thr Gln Pro 
385                 390                 395                 400 


Leu Thr Pro Ser 
                


<210>  4660
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR183__Homo_sapiens__NP_004942

<400>  4660

Met Asp Ile Gln Met Ala Asn Asn Phe Thr Pro Pro Ser Ala Thr Pro 
1               5                   10                  15      


Gln Gly Asn Asp Cys Asp Leu Tyr Ala His His Ser Thr Ala Arg Ile 
            20                  25                  30          


Val Met Pro Leu His Tyr Ser Leu Val Phe Ile Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Ala Leu Val Val Ile Val Gln Asn Arg Lys Lys Ile Asn 
    50                  55                  60                  


Ser Thr Thr Leu Tyr Ser Thr Asn Leu Val Ile Ser Asp Ile Leu Phe 
65                  70                  75                  80  


Thr Thr Ala Leu Pro Thr Arg Ile Ala Tyr Tyr Ala Met Gly Phe Asp 
                85                  90                  95      


Trp Arg Ile Gly Asp Ala Leu Cys Arg Ile Thr Ala Leu Val Phe Tyr 
            100                 105                 110         


Ile Asn Thr Tyr Ala Gly Val Asn Phe Met Thr Cys Leu Ser Ile Asp 
        115                 120                 125             


Arg Phe Ile Ala Val Val His Pro Leu Arg Tyr Asn Lys Ile Lys Arg 
    130                 135                 140                 


Ile Glu His Ala Lys Gly Val Cys Ile Phe Val Trp Ile Leu Val Phe 
145                 150                 155                 160 


Ala Gln Thr Leu Pro Leu Leu Ile Asn Pro Met Ser Lys Gln Glu Ala 
                165                 170                 175     


Glu Arg Ile Thr Cys Met Glu Tyr Pro Asn Phe Glu Glu Thr Lys Ser 
            180                 185                 190         


Leu Pro Trp Ile Leu Leu Gly Ala Cys Phe Ile Gly Tyr Val Leu Pro 
        195                 200                 205             


Leu Ile Ile Ile Leu Ile Cys Tyr Ser Gln Ile Cys Cys Lys Leu Phe 
    210                 215                 220                 


Arg Thr Ala Lys Gln Asn Pro Leu Thr Glu Lys Ser Gly Val Asn Lys 
225                 230                 235                 240 


Lys Ala Leu Asn Thr Ile Ile Leu Ile Ile Val Val Phe Val Leu Cys 
                245                 250                 255     


Phe Thr Pro Tyr His Val Ala Ile Ile Gln His Met Ile Lys Lys Leu 
            260                 265                 270         


Arg Phe Ser Asn Phe Leu Glu Cys Ser Gln Arg His Ser Phe Gln Ile 
        275                 280                 285             


Ser Leu His Phe Thr Val Cys Leu Met Asn Phe Asn Cys Cys Met Asp 
    290                 295                 300                 


Pro Phe Ile Tyr Phe Phe Ala Cys Lys Gly Tyr Lys Arg Lys Val Met 
305                 310                 315                 320 


Arg Met Leu Lys Arg Gln Val Ser Val Ser Ile Ser Ser Ala Val Lys 
                325                 330                 335     


Ser Ala Pro Glu Glu Asn Ser Arg Glu Met Thr Glu Thr Gln Met Met 
            340                 345                 350         


Ile His Ser Lys Ser Ser Asn Gly Lys 
        355                 360     


<210>  4661
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR19__Homo_sapiens__XP_011518926

<400>  4661

Met Lys Glu Ala Ser Phe Phe Phe Ser Pro Thr Arg Ile Lys Arg Lys 
1               5                   10                  15      


Lys Val Asn Met Val Phe Ala His Arg Met Asp Asn Ser Lys Pro His 
            20                  25                  30          


Leu Ile Ile Pro Thr Leu Leu Val Pro Leu Gln Asn Arg Ser Cys Thr 
        35                  40                  45              


Glu Thr Ala Thr Pro Leu Pro Ser Gln Tyr Leu Met Glu Leu Ser Glu 
    50                  55                  60                  


Glu His Ser Trp Met Ser Asn Gln Thr Asp Leu His Tyr Val Leu Lys 
65                  70                  75                  80  


Pro Gly Glu Val Ala Thr Ala Ser Ile Phe Phe Gly Ile Leu Trp Leu 
                85                  90                  95      


Phe Ser Ile Phe Gly Asn Ser Leu Val Cys Leu Val Ile His Arg Ser 
            100                 105                 110         


Arg Arg Thr Gln Ser Thr Thr Asn Tyr Phe Val Val Ser Met Ala Cys 
        115                 120                 125             


Ala Asp Leu Leu Ile Ser Val Ala Ser Thr Pro Phe Val Leu Leu Gln 
    130                 135                 140                 


Phe Thr Thr Gly Arg Trp Thr Leu Gly Ser Ala Thr Cys Lys Val Val 
145                 150                 155                 160 


Arg Tyr Phe Gln Tyr Leu Thr Pro Gly Val Gln Ile Tyr Val Leu Leu 
                165                 170                 175     


Ser Ile Cys Ile Asp Arg Phe Tyr Thr Ile Val Tyr Pro Leu Ser Phe 
            180                 185                 190         


Lys Val Ser Arg Glu Lys Ala Lys Lys Met Ile Ala Ala Ser Trp Val 
        195                 200                 205             


Phe Asp Ala Gly Phe Val Thr Pro Val Leu Phe Phe Tyr Gly Ser Asn 
    210                 215                 220                 


Trp Asp Ser His Cys Asn Tyr Phe Leu Pro Ser Ser Trp Glu Gly Thr 
225                 230                 235                 240 


Ala Tyr Thr Val Ile His Phe Leu Val Gly Phe Val Ile Pro Ser Val 
                245                 250                 255     


Leu Ile Ile Leu Phe Tyr Gln Lys Val Ile Lys Tyr Ile Trp Arg Ile 
            260                 265                 270         


Gly Thr Asp Gly Arg Thr Val Arg Arg Thr Met Asn Ile Val Pro Arg 
        275                 280                 285             


Thr Lys Val Lys Thr Ile Lys Met Phe Leu Ile Leu Asn Leu Leu Phe 
    290                 295                 300                 


Leu Leu Ser Trp Leu Pro Phe His Val Ala Gln Leu Trp His Pro His 
305                 310                 315                 320 


Glu Gln Asp Tyr Lys Lys Ser Ser Leu Val Phe Thr Ala Ile Thr Trp 
                325                 330                 335     


Ile Ser Phe Ser Ser Ser Ala Ser Lys Pro Thr Leu Tyr Ser Ile Tyr 
            340                 345                 350         


Asn Ala Asn Phe Arg Arg Gly Met Lys Glu Thr Phe Cys Met Ser Ser 
        355                 360                 365             


Met Lys Cys Tyr Arg Ser Asn Ala Tyr Thr Ile Thr Thr Ser Ser Arg 
    370                 375                 380                 


Met Ala Lys Lys Asn Tyr Val Gly Ile Ser Glu Ile Pro Ser Met Ala 
385                 390                 395                 400 


Lys Thr Ile Thr Lys Asp Ser Ile Tyr Asp Ser Phe Asp Arg Glu Ala 
                405                 410                 415     


Lys Glu Lys Lys Leu Ala Trp Pro Ile Asn Ser Asn Pro Pro Asn Thr 
            420                 425                 430         


Phe Val 
        


<210>  4662
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR1__Homo_sapiens__NP_001091669

<400>  4662

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  4663
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR20__Homo_sapiens__NP_005284

<400>  4663

Met Pro Ser Val Ser Pro Ala Gly Pro Ser Ala Gly Ala Val Pro Asn 
1               5                   10                  15      


Ala Thr Ala Val Thr Thr Val Arg Thr Asn Ala Ser Gly Leu Glu Val 
            20                  25                  30          


Pro Leu Phe His Leu Phe Ala Arg Leu Asp Glu Glu Leu His Gly Thr 
        35                  40                  45              


Phe Pro Gly Leu Trp Leu Ala Leu Met Ala Val His Gly Ala Ile Phe 
    50                  55                  60                  


Leu Ala Gly Leu Val Leu Asn Gly Leu Ala Leu Tyr Val Phe Cys Cys 
65                  70                  75                  80  


Arg Thr Arg Ala Lys Thr Pro Ser Val Ile Tyr Thr Ile Asn Leu Val 
                85                  90                  95      


Val Thr Asp Leu Leu Val Gly Leu Ser Leu Pro Thr Arg Phe Ala Val 
            100                 105                 110         


Tyr Tyr Gly Ala Arg Gly Cys Leu Arg Cys Ala Phe Pro His Val Leu 
        115                 120                 125             


Gly Tyr Phe Leu Asn Met His Cys Ser Ile Leu Phe Leu Thr Cys Ile 
    130                 135                 140                 


Cys Val Asp Arg Tyr Leu Ala Ile Val Arg Pro Glu Gly Ser Arg Arg 
145                 150                 155                 160 


Cys Arg Gln Pro Ala Cys Ala Arg Ala Val Cys Ala Phe Val Trp Leu 
                165                 170                 175     


Ala Ala Gly Ala Val Thr Leu Ser Val Leu Gly Val Thr Gly Ser Arg 
            180                 185                 190         


Pro Cys Cys Arg Val Phe Ala Leu Thr Val Leu Glu Phe Leu Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Ser Val Phe Thr Gly Arg Ile Met Cys Ala Leu Ser 
    210                 215                 220                 


Arg Pro Gly Leu Leu His Gln Gly Arg Gln Arg Arg Val Arg Ala Met 
225                 230                 235                 240 


Gln Leu Leu Leu Thr Val Leu Ile Ile Phe Leu Val Cys Phe Thr Pro 
                245                 250                 255     


Phe His Ala Arg Gln Val Ala Val Ala Leu Trp Pro Asp Met Pro His 
            260                 265                 270         


His Thr Ser Leu Val Val Tyr His Val Ala Val Thr Leu Ser Ser Leu 
        275                 280                 285             


Asn Ser Cys Met Asp Pro Ile Val Tyr Cys Phe Val Thr Ser Gly Phe 
    290                 295                 300                 


Gln Ala Thr Val Arg Gly Leu Phe Gly Gln His Gly Glu Arg Glu Pro 
305                 310                 315                 320 


Ser Ser Gly Asp Val Val Ser Met His Arg Ser Ser Lys Gly Ser Gly 
                325                 330                 335     


Arg His His Ile Leu Ser Ala Gly Pro His Ala Leu Thr Gln Ala Leu 
            340                 345                 350         


Ala Asn Gly Pro Glu Ala 
        355             


<210>  4664
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR22__Homo_sapiens__XP_011514358

<400>  4664

Met Cys Phe Ser Pro Ile Leu Glu Ile Asn Met Gln Ser Glu Ser Asn 
1               5                   10                  15      


Ile Thr Val Arg Asp Asp Ile Asp Asp Ile Asn Thr Asn Met Tyr Gln 
            20                  25                  30          


Pro Leu Ser Tyr Pro Leu Ser Phe Gln Val Ser Leu Thr Gly Phe Leu 
        35                  40                  45              


Met Leu Glu Ile Val Leu Gly Leu Gly Ser Asn Leu Thr Val Leu Val 
    50                  55                  60                  


Leu Tyr Cys Met Lys Ser Asn Leu Ile Asn Ser Val Ser Asn Ile Ile 
65                  70                  75                  80  


Thr Met Asn Leu His Val Leu Asp Val Ile Ile Cys Val Gly Cys Ile 
                85                  90                  95      


Pro Leu Thr Ile Val Ile Leu Leu Leu Ser Leu Glu Ser Asn Thr Ala 
            100                 105                 110         


Leu Ile Cys Cys Phe His Glu Ala Cys Val Ser Phe Ala Ser Val Ser 
        115                 120                 125             


Thr Ala Ile Asn Val Phe Ala Ile Thr Leu Asp Arg Tyr Asp Ile Ser 
    130                 135                 140                 


Val Lys Pro Ala Asn Arg Ile Leu Thr Met Gly Arg Ala Val Met Leu 
145                 150                 155                 160 


Met Ile Ser Ile Trp Ile Phe Ser Phe Phe Ser Phe Leu Ile Pro Phe 
                165                 170                 175     


Ile Glu Val Asn Phe Phe Ser Leu Gln Ser Gly Asn Thr Trp Glu Asn 
            180                 185                 190         


Lys Thr Leu Leu Cys Val Ser Thr Asn Glu Tyr Tyr Thr Glu Leu Gly 
        195                 200                 205             


Met Tyr Tyr His Leu Leu Val Gln Ile Pro Ile Phe Phe Phe Thr Val 
    210                 215                 220                 


Val Val Met Leu Ile Thr Tyr Thr Lys Ile Leu Gln Ala Leu Asn Ile 
225                 230                 235                 240 


Arg Ile Gly Thr Arg Phe Ser Thr Gly Gln Lys Lys Lys Ala Arg Lys 
                245                 250                 255     


Lys Lys Thr Ile Ser Leu Thr Thr Gln His Glu Ala Thr Asp Met Ser 
            260                 265                 270         


Gln Ser Ser Gly Gly Arg Asn Val Val Phe Gly Val Arg Thr Ser Val 
        275                 280                 285             


Ser Val Ile Ile Ala Leu Arg Arg Ala Val Lys Arg His Arg Glu Arg 
    290                 295                 300                 


Arg Glu Arg Gln Lys Arg Val Phe Arg Met Ser Leu Leu Ile Ile Ser 
305                 310                 315                 320 


Thr Phe Leu Leu Cys Trp Thr Pro Ile Ser Val Leu Asn Thr Thr Ile 
                325                 330                 335     


Leu Cys Leu Gly Pro Ser Asp Leu Leu Val Lys Leu Arg Leu Cys Phe 
            340                 345                 350         


Leu Val Met Ala Tyr Gly Thr Thr Ile Phe His Pro Leu Leu Tyr Ala 
        355                 360                 365             


Phe Thr Arg Gln Lys Phe Gln Lys Val Leu Lys Ser Lys Met Lys Lys 
    370                 375                 380                 


Arg Val Val Ser Ile Val Glu Ala Asp Pro Leu Pro Asn Asn Ala Val 
385                 390                 395                 400 


Ile His Asn Ser Trp Ile Asp Pro Lys Arg Asn Lys Lys Ile Thr Phe 
                405                 410                 415     


Glu Asp Ser Glu Ile Arg Glu Lys Cys Leu Val Pro Gln Val Val Thr 
            420                 425                 430         


Asp 
    


<210>  4665
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR26__Homo_sapiens__NP_703143

<400>  4665

Met Asn Ser Trp Asp Ala Gly Leu Ala Gly Leu Leu Val Gly Thr Met 
1               5                   10                  15      


Gly Val Ser Leu Leu Ser Asn Ala Leu Val Leu Leu Cys Leu Leu His 
            20                  25                  30          


Ser Ala Asp Ile Arg Arg Gln Ala Pro Ala Leu Phe Thr Leu Asn Leu 
        35                  40                  45              


Thr Cys Gly Asn Leu Leu Cys Thr Val Val Asn Met Pro Leu Thr Leu 
    50                  55                  60                  


Ala Gly Val Val Ala Gln Arg Gln Pro Ala Gly Asp Arg Leu Cys Arg 
65                  70                  75                  80  


Leu Ala Ala Phe Leu Asp Thr Phe Leu Ala Ala Asn Ser Met Leu Ser 
                85                  90                  95      


Met Ala Ala Leu Ser Ile Asp Arg Trp Val Ala Val Val Phe Pro Leu 
            100                 105                 110         


Ser Tyr Arg Ala Lys Met Arg Leu Arg Asp Ala Ala Leu Met Val Ala 
        115                 120                 125             


Tyr Thr Trp Leu His Ala Leu Thr Phe Pro Ala Ala Ala Leu Ala Leu 
    130                 135                 140                 


Ser Trp Leu Gly Phe His Gln Leu Tyr Ala Ser Cys Thr Leu Cys Ser 
145                 150                 155                 160 


Arg Arg Pro Asp Glu Arg Leu Arg Phe Ala Val Phe Thr Gly Ala Phe 
                165                 170                 175     


His Ala Leu Ser Phe Leu Leu Ser Phe Val Val Leu Cys Cys Thr Tyr 
            180                 185                 190         


Leu Lys Val Leu Lys Val Ala Arg Phe His Cys Lys Arg Ile Asp Val 
        195                 200                 205             


Ile Thr Met Gln Thr Leu Val Leu Leu Val Asp Leu His Pro Ser Val 
    210                 215                 220                 


Arg Glu Arg Cys Leu Glu Glu Gln Lys Arg Arg Arg Gln Arg Ala Thr 
225                 230                 235                 240 


Lys Lys Ile Ser Thr Phe Ile Gly Thr Phe Leu Val Cys Phe Ala Pro 
                245                 250                 255     


Tyr Val Ile Thr Arg Leu Val Glu Leu Phe Ser Thr Val Pro Ile Gly 
            260                 265                 270         


Ser His Trp Gly Val Leu Ser Lys Cys Leu Ala Tyr Ser Lys Ala Ala 
        275                 280                 285             


Ser Asp Pro Phe Val Tyr Ser Leu Leu Arg His Gln Tyr Arg Lys Ser 
    290                 295                 300                 


Cys Lys Glu Ile Leu Asn Arg Leu Leu His Arg Arg Ser Ile His Ser 
305                 310                 315                 320 


Ser Gly Leu Thr Gly Asp Ser His Ser Gln Asn Ile Leu Pro Val Ser 
                325                 330                 335     


Glu 
    


<210>  4666
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR34__Homo_sapiens__NP_001091048

<400>  4666

Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp 
1               5                   10                  15      


Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln 
            20                  25                  30          


Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met 
        35                  40                  45              


Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile 
    50                  55                  60                  


Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu 
65                  70                  75                  80  


Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val 
                85                  90                  95      


Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met 
            100                 105                 110         


Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys 
        115                 120                 125             


Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu 
    130                 135                 140                 


Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile 
145                 150                 155                 160 


Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys 
                165                 170                 175     


Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu 
            180                 185                 190         


Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg 
        195                 200                 205             


Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val 
    210                 215                 220                 


Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys 
225                 230                 235                 240 


Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro 
                245                 250                 255     


Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu 
            260                 265                 270         


Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile 
        275                 280                 285             


Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile 
    290                 295                 300                 


Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser 
305                 310                 315                 320 


Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys 
                325                 330                 335     


Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg 
            340                 345                 350         


Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr 
        355                 360                 365             


Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr 
    370                 375                 380     


<210>  4667
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR35__Homo_sapiens__NP_001182311

<400>  4667

Met Leu Ser Gly Ser Arg Ala Val Pro Thr Pro His Arg Gly Ser Glu 
1               5                   10                  15      


Glu Leu Leu Lys Tyr Met Leu His Ser Pro Cys Val Ser Leu Thr Met 
            20                  25                  30          


Asn Gly Thr Tyr Asn Thr Cys Gly Ser Ser Asp Leu Thr Trp Pro Pro 
        35                  40                  45              


Ala Ile Lys Leu Gly Phe Tyr Ala Tyr Leu Gly Val Leu Leu Val Leu 
    50                  55                  60                  


Gly Leu Leu Leu Asn Ser Leu Ala Leu Trp Val Phe Cys Cys Arg Met 
65                  70                  75                  80  


Gln Gln Trp Thr Glu Thr Arg Ile Tyr Met Thr Asn Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Cys Leu Leu Cys Thr Leu Pro Phe Val Leu His Ser Leu Arg 
            100                 105                 110         


Asp Thr Ser Asp Thr Pro Leu Cys Gln Leu Ser Gln Gly Ile Tyr Leu 
        115                 120                 125             


Thr Asn Arg Tyr Met Ser Ile Ser Leu Val Thr Ala Ile Ala Val Asp 
    130                 135                 140                 


Arg Tyr Val Ala Val Arg His Pro Leu Arg Ala Arg Gly Leu Arg Ser 
145                 150                 155                 160 


Pro Arg Gln Ala Ala Ala Val Cys Ala Val Leu Trp Val Leu Val Ile 
                165                 170                 175     


Gly Ser Leu Val Ala Arg Trp Leu Leu Gly Ile Gln Glu Gly Gly Phe 
            180                 185                 190         


Cys Phe Arg Ser Thr Arg His Asn Phe Asn Ser Met Ala Phe Pro Leu 
        195                 200                 205             


Leu Gly Phe Tyr Leu Pro Leu Ala Val Val Val Phe Cys Ser Leu Lys 
    210                 215                 220                 


Val Val Thr Ala Leu Ala Gln Arg Pro Pro Thr Asp Val Gly Gln Ala 
225                 230                 235                 240 


Glu Ala Thr Arg Lys Ala Ala Arg Met Val Trp Ala Asn Leu Leu Val 
                245                 250                 255     


Phe Val Val Cys Phe Leu Pro Leu His Val Gly Leu Thr Val Arg Leu 
            260                 265                 270         


Ala Val Gly Trp Asn Ala Cys Ala Leu Leu Glu Thr Ile Arg Arg Ala 
        275                 280                 285             


Leu Tyr Ile Thr Ser Lys Leu Ser Asp Ala Asn Cys Cys Leu Asp Ala 
    290                 295                 300                 


Ile Cys Tyr Tyr Tyr Met Ala Lys Glu Phe Gln Glu Ala Ser Ala Leu 
305                 310                 315                 320 


Ala Val Ala Pro Ser Ala Lys Ala His Lys Ser Gln Asp Ser Leu Cys 
                325                 330                 335     


Val Thr Leu Ala 
            340 


<210>  4668
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR37__Homo_sapiens__NP_005293

<400>  4668

Met Arg Ala Pro Gly Ala Leu Leu Ala Arg Met Ser Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Lys Val Ser Ala Ser Ser Ala Leu Gly Val Ala Pro 
            20                  25                  30          


Ala Ser Arg Asn Glu Thr Cys Leu Gly Glu Ser Cys Ala Pro Thr Val 
        35                  40                  45              


Ile Gln Arg Arg Gly Arg Asp Ala Trp Gly Pro Gly Asn Ser Ala Arg 
    50                  55                  60                  


Asp Val Leu Arg Ala Arg Ala Pro Arg Glu Glu Gln Gly Ala Ala Phe 
65                  70                  75                  80  


Leu Ala Gly Pro Ser Trp Asp Leu Pro Ala Ala Pro Gly Arg Asp Pro 
                85                  90                  95      


Ala Ala Gly Arg Gly Ala Glu Ala Ser Ala Ala Gly Pro Pro Gly Pro 
            100                 105                 110         


Pro Thr Arg Pro Pro Gly Pro Trp Arg Trp Lys Gly Ala Arg Gly Gln 
        115                 120                 125             


Glu Pro Ser Glu Thr Leu Gly Arg Gly Asn Pro Thr Ala Leu Gln Leu 
    130                 135                 140                 


Phe Leu Gln Ile Ser Glu Glu Glu Glu Lys Gly Pro Arg Gly Ala Gly 
145                 150                 155                 160 


Ile Ser Gly Arg Ser Gln Glu Gln Ser Val Lys Thr Val Pro Gly Ala 
                165                 170                 175     


Ser Asp Leu Phe Tyr Trp Pro Arg Arg Ala Gly Lys Leu Gln Gly Ser 
            180                 185                 190         


His His Lys Pro Leu Ser Lys Thr Ala Asn Gly Leu Ala Gly His Glu 
        195                 200                 205             


Gly Trp Thr Ile Ala Leu Pro Gly Arg Ala Leu Ala Gln Asn Gly Ser 
    210                 215                 220                 


Leu Gly Glu Gly Ile His Glu Pro Gly Gly Pro Arg Arg Gly Asn Ser 
225                 230                 235                 240 


Thr Asn Arg Arg Val Arg Leu Lys Asn Pro Phe Tyr Pro Leu Thr Gln 
                245                 250                 255     


Glu Ser Tyr Gly Ala Tyr Ala Val Met Cys Leu Ser Val Val Ile Phe 
            260                 265                 270         


Gly Thr Gly Ile Ile Gly Asn Leu Ala Val Met Cys Ile Val Cys His 
        275                 280                 285             


Asn Tyr Tyr Met Arg Ser Ile Ser Asn Ser Leu Leu Ala Asn Leu Ala 
    290                 295                 300                 


Phe Trp Asp Phe Leu Ile Ile Phe Phe Cys Leu Pro Leu Val Ile Phe 
305                 310                 315                 320 


His Glu Leu Thr Lys Lys Trp Leu Leu Glu Asp Phe Ser Cys Lys Ile 
                325                 330                 335     


Val Pro Tyr Ile Glu Val Ala Ser Leu Gly Val Thr Thr Phe Thr Leu 
            340                 345                 350         


Cys Ala Leu Cys Ile Asp Arg Phe Arg Ala Ala Thr Asn Val Gln Met 
        355                 360                 365             


Tyr Tyr Glu Met Ile Glu Asn Cys Ser Ser Thr Thr Ala Lys Leu Ala 
    370                 375                 380                 


Val Ile Trp Val Gly Ala Leu Leu Leu Ala Leu Pro Glu Val Val Leu 
385                 390                 395                 400 


Arg Gln Leu Ser Lys Glu Asp Leu Gly Phe Ser Gly Arg Ala Pro Ala 
                405                 410                 415     


Glu Arg Cys Ile Ile Lys Ile Ser Pro Asp Leu Pro Asp Thr Ile Tyr 
            420                 425                 430         


Val Leu Ala Leu Thr Tyr Asp Ser Ala Arg Leu Trp Trp Tyr Phe Gly 
        435                 440                 445             


Cys Tyr Phe Cys Leu Pro Thr Leu Phe Thr Ile Thr Cys Ser Leu Val 
    450                 455                 460                 


Thr Ala Arg Lys Ile Arg Lys Ala Glu Lys Ala Cys Thr Arg Gly Asn 
465                 470                 475                 480 


Lys Arg Gln Ile Gln Leu Glu Ser Gln Met Asn Cys Thr Val Val Ala 
                485                 490                 495     


Leu Thr Ile Leu Tyr Gly Phe Cys Ile Ile Pro Glu Asn Ile Cys Asn 
            500                 505                 510         


Ile Val Thr Ala Tyr Met Ala Thr Gly Val Ser Gln Gln Thr Met Asp 
        515                 520                 525             


Leu Leu Asn Ile Ile Ser Gln Phe Leu Leu Phe Phe Lys Ser Cys Val 
    530                 535                 540                 


Thr Pro Val Leu Leu Phe Cys Leu Cys Lys Pro Phe Ser Arg Ala Phe 
545                 550                 555                 560 


Met Glu Cys Cys Cys Cys Cys Cys Glu Glu Cys Ile Gln Lys Ser Ser 
                565                 570                 575     


Thr Val Thr Ser Asp Asp Asn Asp Asn Glu Tyr Thr Thr Glu Leu Glu 
            580                 585                 590         


Leu Ser Pro Phe Ser Thr Ile Arg Arg Glu Met Ser Thr Phe Ala Ser 
        595                 600                 605             


Val Gly Thr His Cys 
    610             


<210>  4669
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR37L1__Homo_sapiens__NP_004758

<400>  4669

Met Arg Trp Leu Trp Pro Leu Ala Val Ser Leu Ala Val Ile Leu Ala 
1               5                   10                  15      


Val Gly Leu Ser Arg Val Ser Gly Gly Ala Pro Leu His Leu Gly Arg 
            20                  25                  30          


His Arg Ala Glu Thr Gln Glu Gln Gln Ser Arg Ser Lys Arg Gly Thr 
        35                  40                  45              


Glu Asp Glu Glu Ala Lys Gly Val Gln Gln Tyr Val Pro Glu Glu Trp 
    50                  55                  60                  


Ala Glu Tyr Pro Arg Pro Ile His Pro Ala Gly Leu Gln Pro Thr Lys 
65                  70                  75                  80  


Pro Leu Val Ala Thr Ser Pro Asn Pro Gly Lys Asp Gly Gly Thr Pro 
                85                  90                  95      


Asp Ser Gly Gln Glu Leu Arg Gly Asn Leu Thr Gly Ala Pro Gly Gln 
            100                 105                 110         


Arg Leu Gln Ile Gln Asn Pro Leu Tyr Pro Val Thr Glu Ser Ser Tyr 
        115                 120                 125             


Ser Ala Tyr Ala Ile Met Leu Leu Ala Leu Val Val Phe Ala Val Gly 
    130                 135                 140                 


Ile Val Gly Asn Leu Ser Val Met Cys Ile Val Trp His Ser Tyr Tyr 
145                 150                 155                 160 


Leu Lys Ser Ala Trp Asn Ser Ile Leu Ala Ser Leu Ala Leu Trp Asp 
                165                 170                 175     


Phe Leu Val Leu Phe Phe Cys Leu Pro Ile Val Ile Phe Asn Glu Ile 
            180                 185                 190         


Thr Lys Gln Arg Leu Leu Gly Asp Val Ser Cys Arg Ala Val Pro Phe 
        195                 200                 205             


Met Glu Val Ser Ser Leu Gly Val Thr Thr Phe Ser Leu Cys Ala Leu 
    210                 215                 220                 


Gly Ile Asp Arg Phe His Val Ala Thr Ser Thr Leu Pro Lys Val Arg 
225                 230                 235                 240 


Pro Ile Glu Arg Cys Gln Ser Ile Leu Ala Lys Leu Ala Val Ile Trp 
                245                 250                 255     


Val Gly Ser Met Thr Leu Ala Val Pro Glu Leu Leu Leu Trp Gln Leu 
            260                 265                 270         


Ala Gln Glu Pro Ala Pro Thr Met Gly Thr Leu Asp Ser Cys Ile Met 
        275                 280                 285             


Lys Pro Ser Ala Ser Leu Pro Glu Ser Leu Tyr Ser Leu Val Met Thr 
    290                 295                 300                 


Tyr Gln Asn Ala Arg Met Trp Trp Tyr Phe Gly Cys Tyr Phe Cys Leu 
305                 310                 315                 320 


Pro Ile Leu Phe Thr Val Thr Cys Gln Leu Val Thr Trp Arg Val Arg 
                325                 330                 335     


Gly Pro Pro Gly Arg Lys Ser Glu Cys Arg Ala Ser Lys His Glu Gln 
            340                 345                 350         


Cys Glu Ser Gln Leu Asn Ser Thr Val Val Gly Leu Thr Val Val Tyr 
        355                 360                 365             


Ala Phe Cys Thr Leu Pro Glu Asn Val Cys Asn Ile Val Val Ala Tyr 
    370                 375                 380                 


Leu Ser Thr Glu Leu Thr Arg Gln Thr Leu Asp Leu Leu Gly Leu Ile 
385                 390                 395                 400 


Asn Gln Phe Ser Thr Phe Phe Lys Gly Ala Ile Thr Pro Val Leu Leu 
                405                 410                 415     


Leu Cys Ile Cys Arg Pro Leu Gly Gln Ala Phe Leu Asp Cys Cys Cys 
            420                 425                 430         


Cys Cys Cys Cys Glu Glu Cys Gly Gly Ala Ser Glu Ala Ser Ala Ala 
        435                 440                 445             


Asn Gly Ser Asp Asn Lys Leu Lys Thr Glu Val Ser Ser Ser Ile Tyr 
    450                 455                 460                 


Phe His Lys Pro Arg Glu Ser Pro Pro Leu Leu Pro Leu Gly Thr Pro 
465                 470                 475                 480 


Cys 
    


<210>  4670
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR39__Homo_sapiens__NP_001499

<400>  4670

Met Ala Ser Pro Ser Leu Pro Gly Ser Asp Cys Ser Gln Ile Ile Asp 
1               5                   10                  15      


His Ser His Val Pro Glu Phe Glu Val Ala Thr Trp Ile Lys Ile Thr 
            20                  25                  30          


Leu Ile Leu Val Tyr Leu Ile Ile Phe Val Met Gly Leu Leu Gly Asn 
        35                  40                  45              


Ser Ala Thr Ile Arg Val Thr Gln Val Leu Gln Lys Lys Gly Tyr Leu 
    50                  55                  60                  


Gln Lys Glu Val Thr Asp His Met Val Ser Leu Ala Cys Ser Asp Ile 
65                  70                  75                  80  


Leu Val Phe Leu Ile Gly Met Pro Met Glu Phe Tyr Ser Ile Ile Trp 
                85                  90                  95      


Asn Pro Leu Thr Thr Ser Ser Tyr Thr Leu Ser Cys Lys Leu His Thr 
            100                 105                 110         


Phe Leu Phe Glu Ala Cys Ser Tyr Ala Thr Leu Leu His Val Leu Thr 
        115                 120                 125             


Leu Ser Phe Glu Arg Tyr Ile Ala Ile Cys His Pro Phe Arg Tyr Lys 
    130                 135                 140                 


Ala Val Ser Gly Pro Cys Gln Val Lys Leu Leu Ile Gly Phe Val Trp 
145                 150                 155                 160 


Val Thr Ser Ala Leu Val Ala Leu Pro Leu Leu Phe Ala Met Gly Thr 
                165                 170                 175     


Glu Tyr Pro Leu Val Asn Val Pro Ser His Arg Gly Leu Thr Cys Asn 
            180                 185                 190         


Arg Ser Ser Thr Arg His His Glu Gln Pro Glu Thr Ser Asn Met Ser 
        195                 200                 205             


Ile Cys Thr Asn Leu Ser Ser Arg Trp Thr Val Phe Gln Ser Ser Ile 
    210                 215                 220                 


Phe Gly Ala Phe Val Val Tyr Leu Val Val Leu Leu Ser Val Ala Phe 
225                 230                 235                 240 


Met Cys Trp Asn Met Met Gln Val Leu Met Lys Ser Gln Lys Gly Ser 
                245                 250                 255     


Leu Ala Gly Gly Thr Arg Pro Pro Gln Leu Arg Lys Ser Glu Ser Glu 
            260                 265                 270         


Glu Ser Arg Thr Ala Arg Arg Gln Thr Ile Ile Phe Leu Arg Leu Ile 
        275                 280                 285             


Val Val Thr Leu Ala Val Cys Trp Met Pro Asn Gln Ile Arg Arg Ile 
    290                 295                 300                 


Met Ala Ala Ala Lys Pro Lys His Asp Trp Thr Arg Ser Tyr Phe Arg 
305                 310                 315                 320 


Ala Tyr Met Ile Leu Leu Pro Phe Ser Glu Thr Phe Phe Tyr Leu Ser 
                325                 330                 335     


Ser Val Ile Asn Pro Leu Leu Tyr Thr Val Ser Ser Gln Gln Phe Arg 
            340                 345                 350         


Arg Val Phe Val Gln Val Leu Cys Cys Arg Leu Ser Leu Gln His Ala 
        355                 360                 365             


Asn His Glu Lys Arg Leu Arg Val His Ala His Ser Thr Thr Asp Ser 
    370                 375                 380                 


Ala Arg Phe Val Gln Arg Pro Leu Leu Phe Ala Ser Arg Arg Gln Ser 
385                 390                 395                 400 


Ser Ala Arg Arg Thr Glu Lys Ile Phe Leu Ser Thr Phe Gln Ser Glu 
                405                 410                 415     


Ala Glu Pro Gln Ser Lys Ser Gln Ser Leu Ser Leu Glu Ser Leu Glu 
            420                 425                 430         


Pro Asn Ser Gly Ala Lys Pro Ala Asn Ser Ala Ala Glu Asn Gly Phe 
        435                 440                 445             


Gln Glu His Glu Val 
    450             


<210>  4671
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR4__Homo_sapiens__NP_005273

<400>  4671

Met Gly Asn His Thr Trp Glu Gly Cys His Val Asp Ser Arg Val Asp 
1               5                   10                  15      


His Leu Phe Pro Pro Ser Leu Tyr Ile Phe Val Ile Gly Val Gly Leu 
            20                  25                  30          


Pro Thr Asn Cys Leu Ala Leu Trp Ala Ala Tyr Arg Gln Val Gln Gln 
        35                  40                  45              


Arg Asn Glu Leu Gly Val Tyr Leu Met Asn Leu Ser Ile Ala Asp Leu 
    50                  55                  60                  


Leu Tyr Ile Cys Thr Leu Pro Leu Trp Val Asp Tyr Phe Leu His His 
65                  70                  75                  80  


Asp Asn Trp Ile His Gly Pro Gly Ser Cys Lys Leu Phe Gly Phe Ile 
                85                  90                  95      


Phe Tyr Thr Asn Ile Tyr Ile Ser Ile Ala Phe Leu Cys Cys Ile Ser 
            100                 105                 110         


Val Asp Arg Tyr Leu Ala Val Ala His Pro Leu Arg Phe Ala Arg Leu 
        115                 120                 125             


Arg Arg Val Lys Thr Ala Val Ala Val Ser Ser Val Val Trp Ala Thr 
    130                 135                 140                 


Glu Leu Gly Ala Asn Ser Ala Pro Leu Phe His Asp Glu Leu Phe Arg 
145                 150                 155                 160 


Asp Arg Tyr Asn His Thr Phe Cys Phe Glu Lys Phe Pro Met Glu Gly 
                165                 170                 175     


Trp Val Ala Trp Met Asn Leu Tyr Arg Val Phe Val Gly Phe Leu Phe 
            180                 185                 190         


Pro Trp Ala Leu Met Leu Leu Ser Tyr Arg Gly Ile Leu Arg Ala Val 
        195                 200                 205             


Arg Gly Ser Val Ser Thr Glu Arg Gln Glu Lys Ala Lys Ile Lys Arg 
    210                 215                 220                 


Leu Ala Leu Ser Leu Ile Ala Ile Val Leu Val Cys Phe Ala Pro Tyr 
225                 230                 235                 240 


His Val Leu Leu Leu Ser Arg Ser Ala Ile Tyr Leu Gly Arg Pro Trp 
                245                 250                 255     


Asp Cys Gly Phe Glu Glu Arg Val Phe Ser Ala Tyr His Ser Ser Leu 
            260                 265                 270         


Ala Phe Thr Ser Leu Asn Cys Val Ala Asp Pro Ile Leu Tyr Cys Leu 
        275                 280                 285             


Val Asn Glu Gly Ala Arg Ser Asp Val Ala Lys Ala Leu His Asn Leu 
    290                 295                 300                 


Leu Arg Phe Leu Ala Ser Asp Lys Pro Gln Glu Met Ala Asn Ala Ser 
305                 310                 315                 320 


Leu Thr Leu Glu Thr Pro Leu Thr Ser Lys Arg Asn Ser Thr Ala Lys 
                325                 330                 335     


Ala Met Thr Gly Ser Trp Ala Ala Thr Pro Pro Ser Gln Gly Asp Gln 
            340                 345                 350         


Val Gln Leu Lys Met Leu Pro Pro Ala Gln 
        355                 360         


<210>  4672
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR50__Homo_sapiens__NP_004215

<400>  4672

Met Gly Pro Thr Leu Ala Val Pro Thr Pro Tyr Gly Cys Ile Gly Cys 
1               5                   10                  15      


Lys Leu Pro Gln Pro Glu Tyr Pro Pro Ala Leu Ile Ile Phe Met Phe 
            20                  25                  30          


Cys Ala Met Val Ile Thr Ile Val Val Asp Leu Ile Gly Asn Ser Met 
        35                  40                  45              


Val Ile Leu Ala Val Thr Lys Asn Lys Lys Leu Arg Asn Ser Gly Asn 
    50                  55                  60                  


Ile Phe Val Val Ser Leu Ser Val Ala Asp Met Leu Val Ala Ile Tyr 
65                  70                  75                  80  


Pro Tyr Pro Leu Met Leu His Ala Met Ser Ile Gly Gly Trp Asp Leu 
                85                  90                  95      


Ser Gln Leu Gln Cys Gln Met Val Gly Phe Ile Thr Gly Leu Ser Val 
            100                 105                 110         


Val Gly Ser Ile Phe Asn Ile Val Ala Ile Ala Ile Asn Arg Tyr Cys 
        115                 120                 125             


Tyr Ile Cys His Ser Leu Gln Tyr Glu Arg Ile Phe Ser Val Arg Asn 
    130                 135                 140                 


Thr Cys Ile Tyr Leu Val Ile Thr Trp Ile Met Thr Val Leu Ala Val 
145                 150                 155                 160 


Leu Pro Asn Met Tyr Ile Gly Thr Ile Glu Tyr Asp Pro Arg Thr Tyr 
                165                 170                 175     


Thr Cys Ile Phe Asn Tyr Leu Asn Asn Pro Val Phe Thr Val Thr Ile 
            180                 185                 190         


Val Cys Ile His Phe Val Leu Pro Leu Leu Ile Val Gly Phe Cys Tyr 
        195                 200                 205             


Val Arg Ile Trp Thr Lys Val Leu Ala Ala Arg Asp Pro Ala Gly Gln 
    210                 215                 220                 


Asn Pro Asp Asn Gln Leu Ala Glu Val Arg Asn Phe Leu Thr Met Phe 
225                 230                 235                 240 


Val Ile Phe Leu Leu Phe Ala Val Cys Trp Cys Pro Ile Asn Val Leu 
                245                 250                 255     


Thr Val Leu Val Ala Val Ser Pro Lys Glu Met Ala Gly Lys Ile Pro 
            260                 265                 270         


Asn Trp Leu Tyr Leu Ala Ala Tyr Phe Ile Ala Tyr Phe Asn Ser Cys 
        275                 280                 285             


Leu Asn Ala Val Ile Tyr Gly Leu Leu Asn Glu Asn Phe Arg Arg Glu 
    290                 295                 300                 


Tyr Trp Thr Ile Phe His Ala Met Arg His Pro Ile Ile Phe Phe Ser 
305                 310                 315                 320 


Gly Leu Ile Ser Asp Ile Arg Glu Met Gln Glu Ala Arg Thr Leu Ala 
                325                 330                 335     


Arg Ala Arg Ala His Ala Arg Asp Gln Ala Arg Glu Gln Asp Arg Ala 
            340                 345                 350         


His Ala Cys Pro Ala Val Glu Glu Thr Pro Met Asn Val Arg Asn Val 
        355                 360                 365             


Pro Leu Pro Gly Asp Ala Ala Ala Gly His Pro Asp Arg Ala Ser Gly 
    370                 375                 380                 


His Pro Lys Pro His Ser Arg Ser Ser Ser Ala Tyr Arg Lys Ser Ala 
385                 390                 395                 400 


Ser Thr His His Lys Ser Val Phe Ser His Ser Lys Ala Ala Ser Gly 
                405                 410                 415     


His Leu Lys Pro Val Ser Gly His Ser Lys Pro Ala Ser Gly His Pro 
            420                 425                 430         


Lys Ser Ala Thr Val Tyr Pro Lys Pro Ala Ser Val His Phe Lys Ala 
        435                 440                 445             


Asp Ser Val His Phe Lys Gly Asp Ser Val His Phe Lys Pro Asp Ser 
    450                 455                 460                 


Val His Phe Lys Pro Ala Ser Ser Asn Pro Lys Pro Ile Thr Gly His 
465                 470                 475                 480 


His Val Ser Ala Gly Ser His Ser Lys Ser Ala Phe Ser Ala Ala Thr 
                485                 490                 495     


Ser His Pro Lys Pro Thr Thr Gly His Ile Lys Pro Ala Thr Ser His 
            500                 505                 510         


Ala Glu Pro Thr Thr Ala Asp Tyr Pro Lys Pro Ala Thr Thr Ser His 
        515                 520                 525             


Pro Lys Pro Thr Ala Ala Asp Asn Pro Glu Leu Ser Ala Ser His Cys 
    530                 535                 540                 


Pro Glu Ile Pro Ala Ile Ala His Pro Val Ser Asp Asp Ser Asp Leu 
545                 550                 555                 560 


Pro Glu Ser Ala Ser Ser Pro Ala Ala Gly Pro Thr Lys Pro Ala Ala 
                565                 570                 575     


Ser Gln Leu Glu Ser Asp Thr Ile Ala Asp Leu Pro Asp Pro Thr Val 
            580                 585                 590         


Val Thr Thr Ser Thr Asn Asp Tyr His Asp Val Val Val Ile Asp Val 
        595                 600                 605             


Glu Asp Asp Pro Asp Glu Met Ala Val 
    610                 615         


<210>  4673
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR52__Homo_sapiens__NP_005675

<400>  4673

Met Asn Glu Ser Arg Trp Thr Glu Trp Arg Ile Leu Asn Met Ser Ser 
1               5                   10                  15      


Gly Ile Val Asn Val Ser Glu Arg His Ser Cys Pro Leu Gly Phe Gly 
            20                  25                  30          


His Tyr Ser Val Val Asp Val Cys Ile Phe Glu Thr Val Val Ile Val 
        35                  40                  45              


Leu Leu Thr Phe Leu Ile Ile Ala Gly Asn Leu Thr Val Ile Phe Val 
    50                  55                  60                  


Phe His Cys Ala Pro Leu Leu His His Tyr Thr Thr Ser Tyr Phe Ile 
65                  70                  75                  80  


Gln Thr Met Ala Tyr Ala Asp Leu Phe Val Gly Val Ser Cys Leu Val 
                85                  90                  95      


Pro Thr Leu Ser Leu Leu His Tyr Ser Thr Gly Val His Glu Ser Leu 
            100                 105                 110         


Thr Cys Gln Val Phe Gly Tyr Ile Ile Ser Val Leu Lys Ser Val Ser 
        115                 120                 125             


Met Ala Cys Leu Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Thr 
    130                 135                 140                 


Lys Pro Leu Ser Tyr Asn Gln Leu Val Thr Pro Cys Arg Leu Arg Ile 
145                 150                 155                 160 


Cys Ile Ile Leu Ile Trp Ile Tyr Ser Cys Leu Ile Phe Leu Pro Ser 
                165                 170                 175     


Phe Phe Gly Trp Gly Lys Pro Gly Tyr His Gly Asp Ile Phe Glu Trp 
            180                 185                 190         


Cys Ala Thr Ser Trp Leu Thr Ser Ala Tyr Phe Thr Gly Phe Ile Val 
        195                 200                 205             


Cys Leu Leu Tyr Ala Pro Ala Ala Phe Val Val Cys Phe Thr Tyr Phe 
    210                 215                 220                 


His Ile Phe Lys Ile Cys Arg Gln His Thr Lys Glu Ile Asn Asp Arg 
225                 230                 235                 240 


Arg Ala Arg Phe Pro Ser His Glu Val Asp Ser Ser Arg Glu Thr Gly 
                245                 250                 255     


His Ser Pro Asp Arg Arg Tyr Ala Met Val Leu Phe Arg Ile Thr Ser 
            260                 265                 270         


Val Phe Tyr Met Leu Trp Leu Pro Tyr Ile Ile Tyr Phe Leu Leu Glu 
        275                 280                 285             


Ser Ser Arg Val Leu Asp Asn Pro Thr Leu Ser Phe Leu Thr Thr Trp 
    290                 295                 300                 


Leu Ala Ile Ser Asn Ser Phe Cys Asn Cys Val Ile Tyr Ser Leu Ser 
305                 310                 315                 320 


Asn Ser Val Phe Arg Leu Gly Leu Arg Arg Leu Ser Glu Thr Met Cys 
                325                 330                 335     


Thr Ser Cys Met Cys Val Lys Asp Gln Glu Ala Gln Glu Pro Lys Pro 
            340                 345                 350         


Arg Lys Arg Ala Asn Ser Cys Ser Ile 
        355                 360     


<210>  4674
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR55__Homo_sapiens__XP_011510479

<400>  4674

Met Ser Gln Gln Asn Thr Ser Gly Asp Cys Leu Phe Asp Gly Val Asn 
1               5                   10                  15      


Glu Leu Met Lys Thr Leu Gln Phe Ala Val His Ile Pro Thr Phe Val 
            20                  25                  30          


Leu Gly Leu Leu Leu Asn Leu Leu Ala Ile His Gly Phe Ser Thr Phe 
        35                  40                  45              


Leu Lys Asn Arg Trp Pro Asp Tyr Ala Ala Thr Ser Ile Tyr Met Ile 
    50                  55                  60                  


Asn Leu Ala Val Phe Asp Leu Leu Leu Val Leu Ser Leu Pro Phe Lys 
65                  70                  75                  80  


Met Val Leu Ser Gln Val Gln Ser Pro Phe Pro Ser Leu Cys Thr Leu 
                85                  90                  95      


Val Glu Cys Leu Tyr Phe Val Ser Met Tyr Gly Ser Val Phe Thr Ile 
            100                 105                 110         


Cys Phe Ile Ser Met Asp Arg Phe Leu Ala Ile Arg Tyr Pro Leu Leu 
        115                 120                 125             


Val Ser His Leu Arg Ser Pro Arg Lys Ile Phe Gly Ile Cys Cys Thr 
    130                 135                 140                 


Ile Trp Val Leu Val Trp Thr Gly Ser Ile Pro Ile Tyr Ser Phe His 
145                 150                 155                 160 


Gly Lys Val Glu Lys Tyr Met Cys Phe His Asn Met Ser Asp Asp Thr 
                165                 170                 175     


Trp Ser Ala Lys Val Phe Phe Pro Leu Glu Val Phe Gly Phe Leu Leu 
            180                 185                 190         


Pro Met Gly Ile Met Gly Phe Cys Cys Ser Arg Ser Ile His Ile Leu 
        195                 200                 205             


Leu Gly Arg Arg Asp His Thr Gln Asp Trp Val Gln Gln Lys Ala Cys 
    210                 215                 220                 


Ile Tyr Ser Ile Ala Ala Ser Leu Ala Val Phe Val Val Ser Phe Leu 
225                 230                 235                 240 


Pro Val His Leu Gly Phe Phe Leu Gln Phe Leu Val Arg Asn Ser Phe 
                245                 250                 255     


Ile Val Glu Cys Arg Ala Lys Gln Ser Ile Ser Phe Phe Leu Gln Leu 
            260                 265                 270         


Ser Met Cys Phe Ser Asn Val Asn Cys Cys Leu Asp Val Phe Cys Tyr 
        275                 280                 285             


Tyr Phe Val Ile Lys Glu Phe Arg Met Asn Ile Arg Ala His Arg Pro 
    290                 295                 300                 


Ser Arg Val Gln Leu Val Leu Gln Asp Thr Thr Ile Ser Arg Gly 
305                 310                 315                 


<210>  4675
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR65__Homo_sapiens__NP_003599

<400>  4675

Met Asn Ser Thr Cys Ile Glu Glu Gln His Asp Leu Asp His Tyr Leu 
1               5                   10                  15      


Phe Pro Ile Val Tyr Ile Phe Val Ile Ile Val Ser Ile Pro Ala Asn 
            20                  25                  30          


Ile Gly Ser Leu Cys Val Ser Phe Leu Gln Ala Lys Lys Glu Ser Glu 
        35                  40                  45              


Leu Gly Ile Tyr Leu Phe Ser Leu Ser Leu Ser Asp Leu Leu Tyr Ala 
    50                  55                  60                  


Leu Thr Leu Pro Leu Trp Ile Asp Tyr Thr Trp Asn Lys Asp Asn Trp 
65                  70                  75                  80  


Thr Phe Ser Pro Ala Leu Cys Lys Gly Ser Ala Phe Leu Met Tyr Met 
                85                  90                  95      


Asn Phe Tyr Ser Ser Thr Ala Phe Leu Thr Cys Ile Ala Val Asp Arg 
            100                 105                 110         


Tyr Leu Ala Val Val Tyr Pro Leu Lys Phe Phe Phe Leu Arg Thr Arg 
        115                 120                 125             


Arg Phe Ala Leu Met Val Ser Leu Ser Ile Trp Ile Leu Glu Thr Ile 
    130                 135                 140                 


Phe Asn Ala Val Met Leu Trp Glu Asp Glu Thr Val Val Glu Tyr Cys 
145                 150                 155                 160 


Asp Ala Glu Lys Ser Asn Phe Thr Leu Cys Tyr Asp Lys Tyr Pro Leu 
                165                 170                 175     


Glu Lys Trp Gln Ile Asn Leu Asn Leu Phe Arg Thr Cys Thr Gly Tyr 
            180                 185                 190         


Ala Ile Pro Leu Val Thr Ile Leu Ile Cys Asn Arg Lys Val Tyr Gln 
        195                 200                 205             


Ala Val Arg His Asn Lys Ala Thr Glu Asn Lys Glu Lys Lys Arg Ile 
    210                 215                 220                 


Ile Lys Leu Leu Val Ser Ile Thr Val Thr Phe Val Leu Cys Phe Thr 
225                 230                 235                 240 


Pro Phe His Val Met Leu Leu Ile Arg Cys Ile Leu Glu His Ala Val 
                245                 250                 255     


Asn Phe Glu Asp His Ser Asn Ser Gly Lys Arg Thr Tyr Thr Met Tyr 
            260                 265                 270         


Arg Ile Thr Val Ala Leu Thr Ser Leu Asn Cys Val Ala Asp Pro Ile 
        275                 280                 285             


Leu Tyr Cys Phe Val Thr Glu Thr Gly Arg Tyr Asp Met Trp Asn Ile 
    290                 295                 300                 


Leu Lys Phe Cys Thr Gly Arg Cys Asn Thr Ser Gln Arg Gln Arg Lys 
305                 310                 315                 320 


Arg Ile Leu Ser Val Ser Thr Lys Asp Thr Met Glu Leu Glu Val Leu 
                325                 330                 335     


Glu 
    


<210>  4676
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR68__Homo_sapiens__NP_001171147

<400>  4676

Met Gly Asn Ile Thr Ala Asp Asn Ser Ser Met Ser Cys Thr Ile Asp 
1               5                   10                  15      


His Thr Ile His Gln Thr Leu Ala Pro Val Val Tyr Val Thr Val Leu 
            20                  25                  30          


Val Val Gly Phe Pro Ala Asn Cys Leu Ser Leu Tyr Phe Gly Tyr Leu 
        35                  40                  45              


Gln Ile Lys Ala Arg Asn Glu Leu Gly Val Tyr Leu Cys Asn Leu Thr 
    50                  55                  60                  


Val Ala Asp Leu Phe Tyr Ile Cys Ser Leu Pro Phe Trp Leu Gln Tyr 
65                  70                  75                  80  


Val Leu Gln His Asp Asn Trp Ser His Gly Asp Leu Ser Cys Gln Val 
                85                  90                  95      


Cys Gly Ile Leu Leu Tyr Glu Asn Ile Tyr Ile Ser Val Gly Phe Leu 
            100                 105                 110         


Cys Cys Ile Ser Val Asp Arg Tyr Leu Ala Val Ala His Pro Phe Arg 
        115                 120                 125             


Phe His Gln Phe Arg Thr Leu Lys Ala Ala Val Gly Val Ser Val Val 
    130                 135                 140                 


Ile Trp Ala Lys Glu Leu Leu Thr Ser Ile Tyr Phe Leu Met His Glu 
145                 150                 155                 160 


Glu Val Ile Glu Asp Glu Asn Gln His Arg Val Cys Phe Glu His Tyr 
                165                 170                 175     


Pro Ile Gln Ala Trp Gln Arg Ala Ile Asn Tyr Tyr Arg Phe Leu Val 
            180                 185                 190         


Gly Phe Leu Phe Pro Ile Cys Leu Leu Leu Ala Ser Tyr Gln Gly Ile 
        195                 200                 205             


Leu Arg Ala Val Arg Arg Ser His Gly Thr Gln Lys Ser Arg Lys Asp 
    210                 215                 220                 


Gln Ile Gln Arg Leu Val Leu Ser Thr Val Val Ile Phe Leu Ala Cys 
225                 230                 235                 240 


Phe Leu Pro Tyr His Val Leu Leu Leu Val Arg Ser Val Trp Glu Ala 
                245                 250                 255     


Ser Cys Asp Phe Ala Lys Gly Val Phe Asn Ala Tyr His Phe Ser Leu 
            260                 265                 270         


Leu Leu Thr Ser Phe Asn Cys Val Ala Asp Pro Val Leu Tyr Cys Phe 
        275                 280                 285             


Val Ser Glu Thr Thr His Arg Asp Leu Ala Arg Leu Arg Gly Ala Cys 
    290                 295                 300                 


Leu Ala Phe Leu Thr Cys Ser Arg Thr Gly Arg Ala Arg Glu Ala Tyr 
305                 310                 315                 320 


Pro Leu Gly Ala Pro Glu Ala Ser Gly Lys Ser Gly Ala Gln Gly Glu 
                325                 330                 335     


Glu Pro Glu Leu Leu Thr Lys Leu His Pro Ala Phe Gln Thr Pro Asn 
            340                 345                 350         


Ser Pro Gly Ser Gly Gly Phe Pro Thr Gly Arg Leu Ala 
        355                 360                 365 


<210>  4677
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR6__Homo_sapiens__NP_001273028

<400>  4677

Met Thr Leu Leu Ala Trp Cys Thr Arg Gly Ala Asn Pro Ala Ala Met 
1               5                   10                  15      


Asn Ala Ser Ala Ala Ser Leu Asn Asp Ser Gln Val Val Val Val Ala 
            20                  25                  30          


Ala Glu Gly Ala Ala Ala Ala Ala Thr Ala Ala Gly Gly Pro Asp Thr 
        35                  40                  45              


Gly Glu Trp Gly Pro Pro Ala Ala Ala Ala Leu Gly Ala Gly Gly Gly 
    50                  55                  60                  


Ala Asn Gly Ser Leu Glu Leu Ser Ser Gln Leu Ser Ala Gly Pro Pro 
65                  70                  75                  80  


Gly Leu Leu Leu Pro Ala Val Asn Pro Trp Asp Val Leu Leu Cys Val 
                85                  90                  95      


Ser Gly Thr Val Ile Ala Gly Glu Asn Ala Leu Val Val Ala Leu Ile 
            100                 105                 110         


Ala Ser Thr Pro Ala Leu Arg Thr Pro Met Phe Val Leu Val Gly Ser 
        115                 120                 125             


Leu Ala Thr Ala Asp Leu Leu Ala Gly Cys Gly Leu Ile Leu His Phe 
    130                 135                 140                 


Val Phe Gln Tyr Leu Val Pro Ser Glu Thr Val Ser Leu Leu Thr Val 
145                 150                 155                 160 


Gly Phe Leu Val Ala Ser Phe Ala Ala Ser Val Ser Ser Leu Leu Ala 
                165                 170                 175     


Ile Thr Val Asp Arg Tyr Leu Ser Leu Tyr Asn Ala Leu Thr Tyr Tyr 
            180                 185                 190         


Ser Arg Arg Thr Leu Leu Gly Val His Leu Leu Leu Ala Ala Thr Trp 
        195                 200                 205             


Thr Val Ser Leu Gly Leu Gly Leu Leu Pro Val Leu Gly Trp Asn Cys 
    210                 215                 220                 


Leu Ala Glu Arg Ala Ala Cys Ser Val Val Arg Pro Leu Ala Arg Ser 
225                 230                 235                 240 


His Val Ala Leu Leu Ser Ala Ala Phe Phe Met Val Phe Gly Ile Met 
                245                 250                 255     


Leu His Leu Tyr Val Arg Ile Cys Gln Val Val Trp Arg His Ala His 
            260                 265                 270         


Gln Ile Ala Leu Gln Gln His Cys Leu Ala Pro Pro His Leu Ala Ala 
        275                 280                 285             


Thr Arg Lys Gly Val Gly Thr Leu Ala Val Val Leu Gly Thr Phe Gly 
    290                 295                 300                 


Ala Ser Trp Leu Pro Phe Ala Ile Tyr Cys Val Val Gly Ser His Glu 
305                 310                 315                 320 


Asp Pro Ala Val Tyr Thr Tyr Ala Thr Leu Leu Pro Ala Thr Tyr Asn 
                325                 330                 335     


Ser Met Ile Asn Pro Ile Ile Tyr Ala Phe Arg Asn Gln Glu Ile Gln 
            340                 345                 350         


Arg Ala Leu Trp Leu Leu Leu Cys Gly Cys Phe Gln Ser Lys Val Pro 
        355                 360                 365             


Phe Arg Ser Arg Ser Pro Ser Glu Val 
    370                 375         


<210>  4678
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR75__Homo_sapiens__NP_006785

<400>  4678

Met Asn Ser Thr Gly His Leu Gln Asp Ala Pro Asn Ala Thr Ser Leu 
1               5                   10                  15      


His Val Pro His Ser Gln Glu Gly Asn Ser Thr Ser Leu Gln Glu Gly 
            20                  25                  30          


Leu Gln Asp Leu Ile His Thr Ala Thr Leu Val Thr Cys Thr Phe Leu 
        35                  40                  45              


Leu Ala Val Ile Phe Cys Leu Gly Ser Tyr Gly Asn Phe Ile Val Phe 
    50                  55                  60                  


Leu Ser Phe Phe Asp Pro Ala Phe Arg Lys Phe Arg Thr Asn Phe Asp 
65                  70                  75                  80  


Phe Met Ile Leu Asn Leu Ser Phe Cys Asp Leu Phe Ile Cys Gly Val 
                85                  90                  95      


Thr Ala Pro Met Phe Thr Phe Val Leu Phe Phe Ser Ser Ala Ser Ser 
            100                 105                 110         


Ile Pro Asp Ala Phe Cys Phe Thr Phe His Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ile Ile Met Ser Leu Lys Thr Val Ala Val Ile Ala Leu His Arg Leu 
    130                 135                 140                 


Arg Met Val Leu Gly Lys Gln Pro Asn Arg Thr Ala Ser Phe Pro Cys 
145                 150                 155                 160 


Thr Val Leu Leu Thr Leu Leu Leu Trp Ala Thr Ser Phe Thr Leu Ala 
                165                 170                 175     


Thr Leu Ala Thr Leu Lys Thr Ser Lys Ser His Leu Cys Leu Pro Met 
            180                 185                 190         


Ser Ser Leu Ile Ala Gly Lys Gly Lys Ala Ile Leu Ser Leu Tyr Val 
        195                 200                 205             


Val Asp Phe Thr Phe Cys Val Ala Val Val Ser Val Ser Tyr Ile Met 
    210                 215                 220                 


Ile Ala Gln Thr Leu Arg Lys Asn Ala Gln Val Arg Lys Cys Pro Pro 
225                 230                 235                 240 


Val Ile Thr Val Asp Ala Ser Arg Pro Gln Pro Phe Met Gly Val Pro 
                245                 250                 255     


Val Gln Gly Gly Gly Asp Pro Ile Gln Cys Ala Met Pro Ala Leu Tyr 
            260                 265                 270         


Arg Asn Gln Asn Tyr Asn Lys Leu Gln His Val Gln Thr Arg Gly Tyr 
        275                 280                 285             


Thr Lys Ser Pro Asn Gln Leu Val Thr Pro Ala Ala Ser Arg Leu Gln 
    290                 295                 300                 


Leu Val Ser Ala Ile Asn Leu Ser Thr Ala Lys Asp Ser Lys Ala Val 
305                 310                 315                 320 


Val Thr Cys Val Ile Ile Val Leu Ser Val Leu Val Cys Cys Leu Pro 
                325                 330                 335     


Leu Gly Ile Ser Leu Val Gln Val Val Leu Ser Ser Asn Gly Ser Phe 
            340                 345                 350         


Ile Leu Tyr Gln Phe Glu Leu Phe Gly Phe Thr Leu Ile Phe Phe Lys 
        355                 360                 365             


Ser Gly Leu Asn Pro Phe Ile Tyr Ser Arg Asn Ser Ala Gly Leu Arg 
    370                 375                 380                 


Arg Lys Val Leu Trp Cys Leu Gln Tyr Ile Gly Leu Gly Phe Phe Cys 
385                 390                 395                 400 


Cys Lys Gln Lys Thr Arg Leu Arg Ala Met Gly Lys Gly Asn Leu Glu 
                405                 410                 415     


Val Asn Arg Asn Lys Ser Ser His His Glu Thr Asn Ser Ala Tyr Met 
            420                 425                 430         


Leu Ser Pro Lys Pro Gln Lys Lys Phe Val Asp Gln Ala Cys Gly Pro 
        435                 440                 445             


Ser His Ser Lys Glu Ser Met Val Ser Pro Lys Ile Ser Ala Gly His 
    450                 455                 460                 


Gln His Cys Gly Gln Ser Ser Ser Thr Pro Ile Asn Thr Arg Ile Glu 
465                 470                 475                 480 


Pro Tyr Tyr Ser Ile Tyr Asn Ser Ser Pro Ser Gln Glu Glu Ser Ser 
                485                 490                 495     


Pro Cys Asn Leu Gln Pro Val Asn Ser Phe Gly Phe Ala Asn Ser Tyr 
            500                 505                 510         


Ile Ala Met His Tyr His Thr Thr Asn Asp Leu Val Gln Glu Tyr Asp 
        515                 520                 525             


Ser Thr Ser Ala Lys Gln Ile Pro Val Pro Ser Val 
    530                 535                 540 


<210>  4679
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR78__Homo_sapiens__NP_543009

<400>  4679

Met Gly Pro Gly Glu Ala Leu Leu Ala Gly Leu Leu Val Met Val Leu 
1               5                   10                  15      


Ala Val Ala Leu Leu Ser Asn Ala Leu Val Leu Leu Cys Cys Ala Tyr 
            20                  25                  30          


Ser Ala Glu Leu Arg Thr Arg Ala Ser Gly Val Leu Leu Val Asn Leu 
        35                  40                  45              


Ser Leu Gly His Leu Leu Leu Ala Ala Leu Asp Met Pro Phe Thr Leu 
    50                  55                  60                  


Leu Gly Val Met Arg Gly Arg Thr Pro Ser Ala Pro Gly Ala Cys Gln 
65                  70                  75                  80  


Val Ile Gly Phe Leu Asp Thr Phe Leu Ala Ser Asn Ala Ala Leu Ser 
                85                  90                  95      


Val Ala Ala Leu Ser Ala Asp Gln Trp Leu Ala Val Gly Phe Pro Leu 
            100                 105                 110         


Arg Tyr Ala Gly Arg Leu Arg Pro Arg Tyr Ala Gly Leu Leu Leu Gly 
        115                 120                 125             


Cys Ala Trp Gly Gln Ser Leu Ala Phe Ser Gly Ala Ala Leu Gly Cys 
    130                 135                 140                 


Ser Trp Leu Gly Tyr Ser Ser Ala Phe Ala Ser Cys Ser Leu Arg Leu 
145                 150                 155                 160 


Pro Pro Glu Pro Glu Arg Pro Arg Phe Ala Ala Phe Thr Ala Thr Leu 
                165                 170                 175     


His Ala Val Gly Phe Val Leu Pro Leu Ala Val Leu Cys Leu Thr Ser 
            180                 185                 190         


Leu Gln Val His Arg Val Ala Arg Arg His Cys Gln Arg Met Asp Thr 
        195                 200                 205             


Val Thr Met Lys Ala Leu Ala Leu Leu Ala Asp Leu His Pro Ser Val 
    210                 215                 220                 


Arg Gln Arg Cys Leu Ile Gln Gln Lys Arg Arg Arg His Arg Ala Thr 
225                 230                 235                 240 


Arg Lys Ile Gly Ile Ala Ile Ala Thr Phe Leu Ile Cys Phe Ala Pro 
                245                 250                 255     


Tyr Val Met Thr Arg Leu Ala Glu Leu Val Pro Phe Val Thr Val Asn 
            260                 265                 270         


Ala Gln Trp Gly Ile Leu Ser Lys Cys Leu Thr Tyr Ser Lys Ala Val 
        275                 280                 285             


Ala Asp Pro Phe Thr Tyr Ser Leu Leu Arg Arg Pro Phe Arg Gln Val 
    290                 295                 300                 


Leu Ala Gly Met Val His Arg Leu Leu Lys Arg Thr Pro Arg Pro Ala 
305                 310                 315                 320 


Ser Thr His Asp Ser Ser Leu Asp Val Ala Gly Met Val His Gln Leu 
                325                 330                 335     


Leu Lys Arg Thr Pro Arg Pro Ala Ser Thr His Asn Gly Ser Val Asp 
            340                 345                 350         


Thr Glu Asn Asp Ser Cys Leu Gln Gln Thr His 
        355                 360             


<210>  4680
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR83__Homo_sapiens__NP_057624

<400>  4680

Met Val Pro His Leu Leu Leu Leu Cys Leu Leu Pro Leu Val Arg Ala 
1               5                   10                  15      


Thr Glu Pro His Glu Gly Arg Ala Asp Glu Gln Ser Ala Glu Ala Ala 
            20                  25                  30          


Leu Ala Val Pro Asn Ala Ser His Phe Phe Ser Trp Asn Asn Tyr Thr 
        35                  40                  45              


Phe Ser Asp Trp Gln Asn Phe Val Gly Arg Arg Arg Tyr Gly Ala Glu 
    50                  55                  60                  


Ser Gln Asn Pro Thr Val Lys Ala Leu Leu Ile Val Ala Tyr Ser Phe 
65                  70                  75                  80  


Ile Ile Val Phe Ser Leu Phe Gly Asn Val Leu Val Cys His Val Ile 
                85                  90                  95      


Phe Lys Asn Gln Arg Met His Ser Ala Thr Ser Leu Phe Ile Val Asn 
            100                 105                 110         


Leu Ala Val Ala Asp Ile Met Ile Thr Leu Leu Asn Thr Pro Phe Thr 
        115                 120                 125             


Leu Val Arg Phe Val Asn Ser Thr Trp Ile Phe Gly Lys Gly Met Cys 
    130                 135                 140                 


His Val Ser Arg Phe Ala Gln Tyr Cys Ser Leu His Val Ser Ala Leu 
145                 150                 155                 160 


Thr Leu Thr Ala Ile Ala Val Asp Arg His Gln Val Ile Met His Pro 
                165                 170                 175     


Leu Lys Pro Arg Ile Ser Ile Thr Lys Gly Val Ile Tyr Ile Ala Val 
            180                 185                 190         


Ile Trp Thr Met Ala Thr Phe Phe Ser Leu Pro His Ala Ile Cys Gln 
        195                 200                 205             


Lys Leu Phe Thr Phe Lys Tyr Ser Glu Asp Ile Val Arg Ser Leu Cys 
    210                 215                 220                 


Leu Pro Asp Phe Pro Glu Pro Ala Asp Leu Phe Trp Lys Tyr Leu Asp 
225                 230                 235                 240 


Leu Ala Thr Phe Ile Leu Leu Tyr Ile Leu Pro Leu Leu Ile Ile Ser 
                245                 250                 255     


Val Ala Tyr Ala Arg Val Ala Lys Lys Leu Trp Leu Cys Asn Met Ile 
            260                 265                 270         


Gly Asp Val Thr Thr Glu Gln Tyr Phe Ala Leu Arg Arg Lys Lys Lys 
        275                 280                 285             


Lys Thr Ile Lys Met Leu Met Leu Val Val Val Leu Phe Ala Leu Cys 
    290                 295                 300                 


Trp Phe Pro Leu Asn Cys Tyr Val Leu Leu Leu Ser Ser Lys Val Ile 
305                 310                 315                 320 


Arg Thr Asn Asn Ala Leu Tyr Phe Ala Phe His Trp Phe Ala Met Ser 
                325                 330                 335     


Ser Thr Cys Tyr Asn Pro Phe Ile Tyr Cys Trp Leu Asn Glu Asn Phe 
            340                 345                 350         


Arg Ile Glu Leu Lys Ala Leu Leu Ser Met Cys Gln Arg Pro Pro Lys 
        355                 360                 365             


Pro Gln Glu Asp Arg Pro Pro Ser Pro Val Pro Ser Phe Arg Val Ala 
    370                 375                 380                 


Trp Thr Glu Lys Asn Asp Gly Gln Arg Ala Pro Leu Ala Asn Asn Leu 
385                 390                 395                 400 


Leu Pro Thr Ser Gln Leu Gln Ser Gly Lys Thr Asp Leu Ser Ser Val 
                405                 410                 415     


Glu Pro Ile Val Thr Met Ser 
            420             


<210>  4681
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPR87__Homo_sapiens__NP_076404

<400>  4681

Met Gly Phe Asn Leu Thr Leu Ala Lys Leu Pro Asn Asn Glu Leu His 
1               5                   10                  15      


Gly Gln Glu Ser His Asn Ser Gly Asn Arg Ser Asp Gly Pro Gly Lys 
            20                  25                  30          


Asn Thr Thr Leu His Asn Glu Phe Asp Thr Ile Val Leu Pro Val Leu 
        35                  40                  45              


Tyr Leu Ile Ile Phe Val Ala Ser Ile Leu Leu Asn Gly Leu Ala Val 
    50                  55                  60                  


Trp Ile Phe Phe His Ile Arg Asn Lys Thr Ser Phe Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys Asn Ile Val Val Ala Asp Leu Ile Met Thr Leu Thr Phe Pro Phe 
                85                  90                  95      


Arg Ile Val His Asp Ala Gly Phe Gly Pro Trp Tyr Phe Lys Phe Ile 
            100                 105                 110         


Leu Cys Arg Tyr Thr Ser Val Leu Phe Tyr Ala Asn Met Tyr Thr Ser 
        115                 120                 125             


Ile Val Phe Leu Gly Leu Ile Ser Ile Asp Arg Tyr Leu Lys Val Val 
    130                 135                 140                 


Lys Pro Phe Gly Asp Ser Arg Met Tyr Ser Ile Thr Phe Thr Lys Val 
145                 150                 155                 160 


Leu Ser Val Cys Val Trp Val Ile Met Ala Val Leu Ser Leu Pro Asn 
                165                 170                 175     


Ile Ile Leu Thr Asn Gly Gln Pro Thr Glu Asp Asn Ile His Asp Cys 
            180                 185                 190         


Ser Lys Leu Lys Ser Pro Leu Gly Val Lys Trp His Thr Ala Val Thr 
        195                 200                 205             


Tyr Val Asn Ser Cys Leu Phe Val Ala Val Leu Val Ile Leu Ile Gly 
    210                 215                 220                 


Cys Tyr Ile Ala Ile Ser Arg Tyr Ile His Lys Ser Ser Arg Gln Phe 
225                 230                 235                 240 


Ile Ser Gln Ser Ser Arg Lys Arg Lys His Asn Gln Ser Ile Arg Val 
                245                 250                 255     


Val Val Ala Val Phe Phe Thr Cys Phe Leu Pro Tyr His Leu Cys Arg 
            260                 265                 270         


Ile Pro Phe Thr Phe Ser His Leu Asp Arg Leu Leu Asp Glu Ser Ala 
        275                 280                 285             


Gln Lys Ile Leu Tyr Tyr Cys Lys Glu Ile Thr Leu Phe Leu Ser Ala 
    290                 295                 300                 


Cys Asn Val Cys Leu Asp Pro Ile Ile Tyr Phe Phe Met Cys Arg Ser 
305                 310                 315                 320 


Phe Ser Arg Arg Leu Phe Lys Lys Ser Asn Ile Arg Thr Arg Ser Glu 
                325                 330                 335     


Ser Ile Arg Ser Leu Gln Ser Val Arg Arg Ser Glu Val Arg Ile Tyr 
            340                 345                 350         


Tyr Asp Tyr Thr Asp Val 
        355             


<210>  4682
<211>  1395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRASP1__Homo_sapiens__NP_001092881

<400>  4682

Met Thr Gly Ala Glu Ile Glu Ser Gly Ala Gln Val Lys Pro Glu Lys 
1               5                   10                  15      


Lys Pro Gly Glu Glu Val Val Gly Gly Ala Glu Ile Glu Asn Asp Val 
            20                  25                  30          


Pro Leu Val Val Arg Pro Lys Val Arg Thr Gln Ala Gln Ile Met Pro 
        35                  40                  45              


Gly Ala Arg Pro Lys Asn Lys Ser Lys Val Met Pro Gly Ala Ser Thr 
    50                  55                  60                  


Lys Val Glu Thr Ser Ala Val Gly Gly Ala Arg Pro Lys Ser Lys Ala 
65                  70                  75                  80  


Lys Ala Ile Pro Val Ser Arg Phe Lys Glu Glu Ala Gln Met Trp Ala 
                85                  90                  95      


Gln Pro Arg Phe Gly Ala Glu Arg Leu Ser Lys Thr Glu Arg Asn Ser 
            100                 105                 110         


Gln Thr Asn Ile Ile Ala Ser Pro Leu Val Ser Thr Asp Ser Val Leu 
        115                 120                 125             


Val Ala Lys Thr Lys Tyr Leu Ser Glu Asp Arg Glu Leu Val Asn Thr 
    130                 135                 140                 


Asp Thr Glu Ser Phe Pro Arg Arg Lys Ala His Tyr Gln Ala Gly Phe 
145                 150                 155                 160 


Gln Pro Ser Phe Arg Ser Lys Glu Glu Thr Asn Met Gly Ser Trp Cys 
                165                 170                 175     


Cys Pro Arg Pro Thr Ser Lys Gln Glu Ala Ser Pro Asn Ser Asp Phe 
            180                 185                 190         


Lys Trp Val Asp Lys Ser Val Ser Ser Leu Phe Trp Ser Gly Asp Glu 
        195                 200                 205             


Val Thr Ala Lys Phe His Pro Gly Asn Arg Val Lys Asp Ser Asn Arg 
    210                 215                 220                 


Ser Met His Met Ala Asn Gln Glu Ala Asn Thr Met Ser Arg Ser Gln 
225                 230                 235                 240 


Thr Asn Gln Glu Leu Tyr Ile Ala Ser Ser Ser Gly Ser Glu Asp Glu 
                245                 250                 255     


Ser Val Lys Thr Pro Trp Phe Trp Ala Arg Asp Lys Thr Asn Thr Trp 
            260                 265                 270         


Ser Gly Pro Arg Glu Asp Pro Asn Ser Arg Ser Arg Phe Arg Ser Lys 
        275                 280                 285             


Lys Glu Val Tyr Val Glu Ser Ser Ser Gly Ser Glu His Glu Asp His 
    290                 295                 300                 


Leu Glu Ser Trp Phe Gly Ala Gly Lys Glu Ala Lys Phe Arg Ser Lys 
305                 310                 315                 320 


Met Arg Ala Gly Lys Glu Ala Asn Asn Arg Ala Arg His Arg Ala Lys 
                325                 330                 335     


Arg Glu Ala Cys Ile Asp Phe Met Pro Gly Ser Ile Asp Val Ile Lys 
            340                 345                 350         


Lys Glu Ser Cys Phe Trp Pro Glu Glu Asn Ala Asn Thr Phe Ser Arg 
        355                 360                 365             


Pro Met Ile Lys Lys Glu Ala Arg Ala Arg Ala Met Thr Lys Glu Glu 
    370                 375                 380                 


Ala Lys Thr Lys Ala Arg Ala Arg Ala Lys Gln Glu Ala Arg Ser Glu 
385                 390                 395                 400 


Glu Glu Ala Leu Ile Gly Thr Trp Phe Trp Ala Thr Asp Glu Ser Ser 
                405                 410                 415     


Met Ala Asp Glu Ala Ser Ile Glu Ser Ser Leu Gln Val Glu Asp Glu 
            420                 425                 430         


Ser Ile Ile Gly Ser Trp Phe Trp Thr Glu Glu Glu Ala Ser Met Gly 
        435                 440                 445             


Thr Gly Ala Ser Ser Lys Ser Arg Pro Arg Thr Asp Gly Glu Arg Ile 
    450                 455                 460                 


Gly Asp Ser Leu Phe Gly Ala Arg Glu Lys Thr Ser Met Lys Thr Gly 
465                 470                 475                 480 


Ala Glu Ala Thr Ser Glu Ser Ile Leu Ala Ala Asp Asp Glu Gln Val 
                485                 490                 495     


Ile Ile Gly Ser Trp Phe Trp Ala Gly Glu Glu Val Asn Gln Glu Ala 
            500                 505                 510         


Glu Glu Glu Thr Ile Phe Gly Ser Trp Phe Trp Val Ile Asp Ala Ala 
        515                 520                 525             


Ser Val Glu Ser Gly Val Gly Val Ser Cys Glu Ser Arg Thr Arg Ser 
    530                 535                 540                 


Glu Glu Glu Glu Val Ile Gly Pro Trp Phe Trp Ser Gly Glu Gln Val 
545                 550                 555                 560 


Asp Ile Glu Ala Gly Ile Gly Glu Glu Ala Arg Pro Gly Ala Glu Glu 
                565                 570                 575     


Glu Thr Ile Phe Gly Ser Trp Phe Trp Ala Glu Asn Gln Thr Tyr Met 
            580                 585                 590         


Asp Cys Arg Ala Glu Thr Ser Cys Asp Thr Met Gln Gly Ala Glu Glu 
        595                 600                 605             


Glu Glu Pro Ile Ile Gly Ser Trp Phe Trp Thr Arg Val Glu Ala Cys 
    610                 615                 620                 


Val Glu Gly Asp Val Asn Ser Lys Ser Ser Leu Glu Asp Lys Glu Glu 
625                 630                 635                 640 


Ala Met Ile Pro Cys Phe Gly Ala Lys Glu Glu Val Ser Met Lys His 
                645                 650                 655     


Gly Thr Gly Val Arg Cys Arg Phe Met Ala Gly Ala Glu Glu Thr Asn 
            660                 665                 670         


Asn Lys Ser Cys Phe Trp Ala Glu Lys Glu Pro Cys Met Tyr Pro Ala 
        675                 680                 685             


Gly Gly Gly Ser Trp Lys Ser Arg Pro Glu Glu Glu Glu Asp Ile Val 
    690                 695                 700                 


Asn Ser Trp Phe Trp Ser Arg Lys Tyr Thr Lys Pro Glu Ala Ile Ile 
705                 710                 715                 720 


Gly Ser Trp Leu Trp Ala Thr Glu Glu Ser Asn Ile Asp Gly Thr Gly 
                725                 730                 735     


Glu Lys Ala Lys Leu Leu Thr Glu Glu Glu Thr Ile Ile Asn Ser Trp 
            740                 745                 750         


Phe Trp Lys Glu Asp Glu Ala Ile Ser Glu Ala Thr Asp Arg Glu Glu 
        755                 760                 765             


Ser Arg Pro Glu Ala Glu Glu Gly Asp Ile Ile Gly Ser Trp Phe Trp 
    770                 775                 780                 


Ala Gly Glu Glu Asp Arg Leu Glu Pro Ala Ala Glu Thr Arg Glu Glu 
785                 790                 795                 800 


Asp Arg Leu Ala Ala Glu Lys Glu Gly Ile Val Gly Ser Trp Phe Gly 
                805                 810                 815     


Ala Arg Glu Glu Thr Ile Arg Arg Glu Ala Gly Ser Cys Ser Lys Ser 
            820                 825                 830         


Ser Pro Lys Ala Glu Glu Glu Glu Val Ile Ile Gly Ser Trp Phe Trp 
        835                 840                 845             


Glu Glu Glu Ala Ser Pro Glu Ala Val Ala Gly Val Gly Phe Glu Ser 
    850                 855                 860                 


Lys Pro Gly Thr Glu Glu Glu Glu Ile Thr Val Gly Ser Trp Phe Trp 
865                 870                 875                 880 


Pro Glu Glu Glu Ala Ser Ile Gln Ala Gly Ser Gln Ala Val Glu Glu 
                885                 890                 895     


Met Glu Ser Glu Thr Glu Glu Glu Thr Ile Phe Gly Ser Trp Phe Trp 
            900                 905                 910         


Asp Gly Lys Glu Val Ser Glu Glu Ala Gly Pro Cys Cys Val Ser Lys 
        915                 920                 925             


Pro Glu Asp Asp Glu Glu Met Ile Val Glu Ser Trp Phe Trp Ser Arg 
    930                 935                 940                 


Asp Lys Ala Ile Lys Glu Thr Gly Thr Val Ala Thr Cys Glu Ser Lys 
945                 950                 955                 960 


Pro Glu Asn Glu Glu Gly Ala Ile Val Gly Ser Trp Phe Glu Ala Glu 
                965                 970                 975     


Asp Glu Val Asp Asn Arg Thr Asp Asn Gly Ser Asn Cys Gly Ser Arg 
            980                 985                 990         


Thr Leu Ala Asp Glu Asp Glu Ala  Ile Val Gly Ser Trp  Phe Trp Ala 
        995                 1000                 1005             


Gly Asp  Glu Ala His Phe Glu  Ser Asn Pro Ser Pro  Val Phe Arg 
    1010                 1015                 1020             


Ala Ile  Cys Arg Ser Thr Cys  Ser Val Glu Gln Glu  Pro Asp Pro 
    1025                 1030                 1035             


Ser Arg  Arg Pro Gln Ser Trp  Glu Glu Val Thr Val  Gln Phe Lys 
    1040                 1045                 1050             


Pro Gly  Pro Trp Gly Arg Val  Gly Phe Pro Ser Ile  Ser Pro Phe 
    1055                 1060                 1065             


Arg Phe  Pro Lys Glu Ala Ala  Ser Leu Phe Cys Glu  Met Phe Gly 
    1070                 1075                 1080             


Gly Lys  Pro Arg Asn Met Val  Leu Ser Pro Glu Gly  Glu Asp Gln 
    1085                 1090                 1095             


Glu Ser  Leu Leu Gln Pro Asp  Gln Pro Ser Pro Glu  Phe Pro Phe 
    1100                 1105                 1110             


Gln Tyr  Asp Pro Ser Tyr Arg  Ser Val Gln Glu Ile  Arg Glu His 
    1115                 1120                 1125             


Leu Arg  Ala Lys Glu Ser Thr  Glu Pro Glu Ser Ser  Ser Cys Asn 
    1130                 1135                 1140             


Cys Ile  Gln Cys Glu Leu Lys  Ile Gly Ser Glu Glu  Phe Glu Glu 
    1145                 1150                 1155             


Leu Leu  Leu Leu Met Glu Lys  Ile Arg Asp Pro Phe  Ile His Glu 
    1160                 1165                 1170             


Ile Ser  Lys Ile Ala Met Gly  Met Arg Ser Ala Ser  Gln Phe Thr 
    1175                 1180                 1185             


Arg Asp  Phe Ile Arg Asp Ser  Gly Val Val Ser Leu  Ile Glu Thr 
    1190                 1195                 1200             


Leu Leu  Asn Tyr Pro Ser Ser  Arg Val Arg Thr Ser  Phe Leu Glu 
    1205                 1210                 1215             


Asn Met  Ile Arg Met Ala Pro  Pro Tyr Pro Asn Leu  Asn Ile Ile 
    1220                 1225                 1230             


Gln Thr  Tyr Ile Cys Lys Val  Cys Glu Glu Thr Leu  Ala Tyr Ser 
    1235                 1240                 1245             


Val Asp  Ser Pro Glu Gln Leu  Ser Gly Ile Arg Met  Ile Arg His 
    1250                 1255                 1260             


Leu Thr  Thr Thr Thr Asp Tyr  His Thr Leu Val Ala  Asn Tyr Met 
    1265                 1270                 1275             


Ser Gly  Phe Leu Ser Leu Leu  Ala Thr Gly Asn Ala  Lys Thr Arg 
    1280                 1285                 1290             


Phe His  Val Leu Lys Met Leu  Leu Asn Leu Ser Glu  Asn Leu Phe 
    1295                 1300                 1305             


Met Thr  Lys Glu Leu Leu Ser  Ala Glu Ala Val Ser  Glu Phe Ile 
    1310                 1315                 1320             


Gly Leu  Phe Asn Arg Glu Glu  Thr Asn Asp Asn Ile  Gln Ile Val 
    1325                 1330                 1335             


Leu Ala  Ile Phe Glu Asn Ile  Gly Asn Asn Ile Lys  Lys Glu Thr 
    1340                 1345                 1350             


Val Phe  Ser Asp Asp Asp Phe  Asn Ile Glu Pro Leu  Ile Ser Ala 
    1355                 1360                 1365             


Phe His  Lys Val Glu Lys Phe  Ala Lys Glu Leu Gln  Gly Lys Thr 
    1370                 1375                 1380             


Asp Asn  Gln Asn Asp Pro Glu  Gly Asp Gln Glu Asn  
    1385                 1390                 1395 


<210>  4683
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRC5A__Homo_sapiens__NP_003970

<400>  4683

Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                  15      


Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                  25                  30          


Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                  40                  45              


Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                  55                  60                  


Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                  70                  75                  80  


Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                  90                  95      


Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                 105                 110         


Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                 120                 125             


Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                 135                 140                 


Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                 150                 155                 160 


Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                 170                 175     


Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         


Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                 200                 205             


His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                 215                 220                 


Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                 230                 235                 240 


Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                 250                 255     


Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                 265                 270         


Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                 280                 285             


Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                 295                 300                 


Ile Thr Gln Gly Phe Glu Glu Thr Gly Asp Thr Leu Tyr Ala Pro Tyr 
305                 310                 315                 320 


Ser Thr His Phe Gln Leu Gln Asn Gln Pro Pro Gln Lys Glu Phe Ser 
                325                 330                 335     


Ile Pro Arg Ala His Ala Trp Pro Ser Pro Tyr Lys Asp Tyr Glu Val 
            340                 345                 350         


Lys Lys Glu Gly Ser 
        355         


<210>  4684
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRC5B__Homo_sapiens__NP_001291700

<400>  4684

Met Cys Ala Val Gly Val Val Ala Ile Leu Arg Arg Asp Pro Arg Glu 
1               5                   10                  15      


Gly Cys Thr Asp Trp Thr Cys Val Phe Arg Gly Ala Lys Glu Ala Gly 
            20                  25                  30          


Val Gly Pro Ser Val Arg Lys Arg Thr Thr Thr Ser Gly Ser Trp Ala 
        35                  40                  45              


Val Arg Arg Glu Lys Ser Val Ser Arg Arg Asn Leu Pro Gly Gly Gly 
    50                  55                  60                  


Leu Ala Val Cys Val Arg Leu Gly Val Tyr Arg Gly Val Gly Asp Phe 
65                  70                  75                  80  


Glu Arg His Arg Ala Gly Ser Ile Leu Ser Ala Ser Trp Thr Trp Cys 
                85                  90                  95      


Trp Cys Val Ser Gly Lys Leu Leu Leu Met Asn Pro Pro Trp Ser Val 
            100                 105                 110         


Ala Trp Gly Gln Glu Gly Phe Arg Ala Gly Thr Pro Gly Ser Arg Tyr 
        115                 120                 125             


Leu Pro Arg Met Phe Val Ala Ser Glu Arg Lys Met Arg Ala His Gln 
    130                 135                 140                 


Val Leu Thr Phe Leu Leu Leu Phe Val Ile Thr Ser Val Ala Ser Glu 
145                 150                 155                 160 


Asn Ala Ser Thr Ser Arg Gly Cys Gly Leu Asp Leu Leu Pro Gln Tyr 
                165                 170                 175     


Val Ser Leu Cys Asp Leu Asp Ala Ile Trp Gly Ile Val Val Glu Ala 
            180                 185                 190         


Val Ala Gly Ala Gly Ala Leu Ile Thr Leu Leu Leu Met Leu Ile Leu 
        195                 200                 205             


Leu Val Arg Leu Pro Phe Ile Lys Glu Lys Glu Lys Lys Ser Pro Val 
    210                 215                 220                 


Gly Leu His Phe Leu Phe Leu Leu Gly Thr Leu Gly Leu Phe Gly Leu 
225                 230                 235                 240 


Thr Phe Ala Phe Ile Ile Gln Glu Asp Glu Thr Ile Cys Ser Val Arg 
                245                 250                 255     


Arg Phe Leu Trp Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu 
            260                 265                 270         


Ser Gln Ala Trp Arg Val Arg Arg Leu Val Arg His Gly Thr Gly Pro 
        275                 280                 285             


Ala Gly Trp Gln Leu Val Gly Leu Ala Leu Cys Leu Met Leu Val Gln 
    290                 295                 300                 


Val Ile Ile Ala Val Glu Trp Leu Val Leu Thr Val Leu Arg Asp Thr 
305                 310                 315                 320 


Arg Pro Ala Cys Ala Tyr Glu Pro Met Asp Phe Val Met Ala Leu Ile 
                325                 330                 335     


Tyr Asp Met Val Leu Leu Val Val Thr Leu Gly Leu Ala Leu Phe Thr 
            340                 345                 350         


Leu Cys Gly Lys Phe Lys Arg Trp Lys Leu Asn Gly Ala Phe Leu Leu 
        355                 360                 365             


Ile Thr Ala Phe Leu Ser Val Leu Ile Trp Val Ala Trp Met Thr Met 
    370                 375                 380                 


Tyr Leu Phe Gly Asn Val Lys Leu Gln Gln Gly Asp Ala Trp Asn Asp 
385                 390                 395                 400 


Pro Thr Leu Ala Ile Thr Leu Ala Ala Ser Gly Trp Val Phe Val Ile 
                405                 410                 415     


Phe His Ala Ile Pro Glu Ile His Cys Thr Leu Leu Pro Ala Leu Gln 
            420                 425                 430         


Glu Asn Thr Pro Asn Tyr Phe Asp Thr Ser Gln Pro Arg Met Arg Glu 
        435                 440                 445             


Thr Ala Phe Glu Glu Asp Val Gln Leu Pro Arg Ala Tyr Met Glu Asn 
    450                 455                 460                 


Lys Ala Phe Ser Met Asp Glu His Asn Ala Ala Leu Arg Thr Ala Gly 
465                 470                 475                 480 


Phe Pro Asn Gly Ser Leu Gly Lys Arg Pro Ser Gly Ser Leu Gly Lys 
                485                 490                 495     


Arg Pro Ser Ala Pro Phe Arg Ser Asn Val Tyr Gln Pro Thr Glu Met 
            500                 505                 510         


Ala Val Val Leu Asn Gly Gly Thr Ile Pro Thr Ala Pro Pro Ser His 
        515                 520                 525             


Thr Gly Arg His Leu Trp 
    530                 


<210>  4685
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRC5C__Homo_sapiens__NP_061123

<400>  4685

Met Gly Thr Gln Pro Glu Pro Gly Leu Gly Ala Arg Met Ala Ile His 
1               5                   10                  15      


Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe Leu Phe Pro Gly 
            20                  25                  30          


Ala Trp Ala Gln Gly His Val Pro Pro Gly Cys Ser Gln Gly Leu Asn 
        35                  40                  45              


Pro Leu Tyr Tyr Asn Leu Cys Asp Arg Ser Gly Ala Trp Gly Ile Val 
    50                  55                  60                  


Leu Glu Ala Val Ala Gly Ala Gly Ile Val Thr Thr Phe Val Leu Thr 
65                  70                  75                  80  


Ile Ile Leu Val Ala Ser Leu Pro Phe Val Gln Asp Thr Lys Lys Arg 
                85                  90                  95      


Ser Leu Leu Gly Thr Gln Val Phe Phe Leu Leu Gly Thr Leu Gly Leu 
            100                 105                 110         


Phe Cys Leu Val Phe Ala Cys Val Val Lys Pro Asp Phe Ser Thr Cys 
        115                 120                 125             


Ala Ser Arg Arg Phe Leu Phe Gly Val Leu Phe Ala Ile Cys Phe Ser 
    130                 135                 140                 


Cys Leu Ala Ala His Val Phe Ala Leu Asn Phe Leu Ala Arg Lys Asn 
145                 150                 155                 160 


His Gly Pro Arg Gly Trp Val Ile Phe Thr Val Ala Leu Leu Leu Thr 
                165                 170                 175     


Leu Val Glu Val Ile Ile Asn Thr Glu Trp Leu Ile Ile Thr Leu Val 
            180                 185                 190         


Arg Gly Ser Gly Glu Gly Gly Pro Gln Gly Asn Ser Ser Ala Gly Trp 
        195                 200                 205             


Ala Val Ala Ser Pro Cys Ala Ile Ala Asn Met Asp Phe Val Met Ala 
    210                 215                 220                 


Leu Ile Tyr Val Met Leu Leu Leu Leu Gly Ala Phe Leu Gly Ala Trp 
225                 230                 235                 240 


Pro Ala Leu Cys Gly Arg Tyr Lys Arg Trp Arg Lys His Gly Val Phe 
                245                 250                 255     


Val Leu Leu Thr Thr Ala Thr Ser Val Ala Ile Trp Val Val Trp Ile 
            260                 265                 270         


Val Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser Pro Thr Trp Asp 
        275                 280                 285             


Asp Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala Trp Ala Phe Val 
    290                 295                 300                 


Leu Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr Lys Ser Ser Pro 
305                 310                 315                 320 


Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg Gly Val Gly Tyr 
                325                 330                 335     


Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met Phe Val Glu Asn 
            340                 345                 350         


Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys Arg Pro Val Ser 
        355                 360                 365             


Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser Val Tyr Gln Pro 
    370                 375                 380                 


Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu Gly Ala Tyr Asp 
385                 390                 395                 400 


Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val Met Gly Ser Ala 
                405                 410                 415     


Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala Gln Ser His Gln 
            420                 425                 430         


Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln Val Phe Arg Asn 
        435                 440                 445             


Pro Tyr Val Trp Asp 
    450             


<210>  4686
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRC5D__Homo_sapiens__NP_061124

<400>  4686

Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys 
1               5                   10                  15      


Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu 
            20                  25                  30          


Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 
        35                  40                  45              


Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu 
    50                  55                  60                  


Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe 
65                  70                  75                  80  


Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 
                85                  90                  95      


Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser 
            100                 105                 110         


Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr 
        115                 120                 125             


Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala 
    130                 135                 140                 


Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn 
145                 150                 155                 160 


Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr 
                165                 170                 175     


Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 
            180                 185                 190         


Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile 
        195                 200                 205             


Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 
    210                 215                 220                 


Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro 
225                 230                 235                 240 


Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu 
                245                 250                 255     


Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu 
            260                 265                 270         


Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser 
        275                 280                 285             


Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Ala Arg Asp Ser Asp Gly 
    290                 295                 300                 


Ala Glu Glu Asp Val Ala Leu Thr Ser Tyr Gly Thr Pro Ile Gln Pro 
305                 310                 315                 320 


Gln Thr Val Asp Pro Thr Gln Glu Cys Phe Ile Pro Gln Ala Lys Leu 
                325                 330                 335     


Ser Pro Gln Gln Asp Ala Gly Gly Val 
            340                 345 


<210>  4687
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRC6A__Homo_sapiens__NP_001273283

<400>  4687

Met Ala Phe Leu Ile Ile Leu Ile Thr Cys Phe Val Ile Ile Leu Ala 
1               5                   10                  15      


Thr Ser Gln Pro Cys Gln Thr Pro Asp Asp Phe Val Ala Ala Thr Ser 
            20                  25                  30          


Pro Gly His Ile Ile Ile Gly Gly Leu Phe Ala Ile His Glu Lys Met 
        35                  40                  45              


Leu Ser Ser Glu Asp Ser Pro Arg Arg Pro Gln Ile Gln Glu Cys Val 
    50                  55                  60                  


Gly Phe Glu Ile Ser Val Phe Leu Gln Thr Leu Ala Met Ile His Ser 
65                  70                  75                  80  


Ile Glu Met Ile Asn Asn Ser Thr Leu Leu Pro Gly Val Lys Leu Gly 
                85                  90                  95      


Tyr Glu Ile Tyr Asp Thr Cys Thr Glu Val Thr Val Ala Met Ala Ala 
            100                 105                 110         


Thr Leu Arg Phe Leu Ser Lys Phe Asn Cys Ser Arg Glu Thr Val Glu 
        115                 120                 125             


Phe Lys Cys Asp Tyr Ser Ser Tyr Met Pro Arg Val Lys Ala Val Ile 
    130                 135                 140                 


Gly Ser Gly Tyr Ser Glu Ile Thr Met Ala Val Ser Arg Met Leu Asn 
145                 150                 155                 160 


Leu Gln Leu Met Pro Gln Val Gly Tyr Glu Ser Thr Ala Glu Ile Leu 
                165                 170                 175     


Ser Asp Lys Ile Arg Phe Pro Ser Phe Leu Arg Thr Val Pro Ser Asp 
            180                 185                 190         


Phe His Gln Ile Lys Ala Met Ala His Leu Ile Gln Lys Ser Gly Trp 
        195                 200                 205             


Asn Trp Ile Gly Ile Ile Thr Thr Asp Asp Asp Tyr Gly Arg Leu Ala 
    210                 215                 220                 


Leu Asn Thr Phe Ile Ile Gln Ala Glu Ala Asn Asn Val Cys Ile Ala 
225                 230                 235                 240 


Phe Lys Glu Val Leu Pro Ala Phe Leu Ser Asp Asn Thr Ile Glu Val 
                245                 250                 255     


Arg Ile Asn Arg Thr Leu Lys Lys Ile Ile Leu Glu Ala Gln Leu Leu 
            260                 265                 270         


Gly Val Leu Lys Asn Val Thr Phe Thr Asp Gly Trp Asn Ser Phe His 
        275                 280                 285             


Phe Asp Ala His Gly Asp Leu Asn Thr Gly Tyr Asp Val Val Leu Trp 
    290                 295                 300                 


Lys Glu Ile Asn Gly His Met Thr Val Thr Lys Met Ala Glu Tyr Asp 
305                 310                 315                 320 


Leu Gln Asn Asp Val Phe Ile Ile Pro Asp Gln Glu Thr Lys Asn Glu 
                325                 330                 335     


Phe Arg Asn Leu Lys Gln Ile Gln Ser Lys Cys Ser Lys Glu Cys Ser 
            340                 345                 350         


Pro Gly Gln Met Lys Lys Thr Thr Arg Ser Gln His Ile Cys Cys Tyr 
        355                 360                 365             


Glu Cys Gln Asn Cys Pro Glu Asn His Tyr Thr Asn Gln Thr Asp Met 
    370                 375                 380                 


Pro His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val Arg 
385                 390                 395                 400 


Ser Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn Asp 
                405                 410                 415     


Ser Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile Phe 
            420                 425                 430         


Val Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro Val 
        435                 440                 445             


Val Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu Cys 
    450                 455                 460                 


His Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro Gln 
465                 470                 475                 480 


Asp Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe Thr 
                485                 490                 495     


Leu Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu Ala 
            500                 505                 510         


Phe Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr Arg 
        515                 520                 525             


Pro Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile Cys 
    530                 535                 540                 


Thr Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val Ser 
545                 550                 555                 560 


Leu Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu Ala 
                565                 570                 575     


Phe Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys Phe 
            580                 585                 590         


Ile Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys Phe 
        595                 600                 605             


Ile Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe Ile 
    610                 615                 620                 


Pro Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu Ile 
625                 630                 635                 640 


Ile Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe Ile 
                645                 650                 655     


Pro Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys Ser 
            660                 665                 670         


Ala Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser Ser 
        675                 680                 685             


Ile Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val Thr 
    690                 695                 700                 


Met Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys Ser 
705                 710                 715                 720 


Lys Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn Ala 
                725                 730                 735     


Thr Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile 
            740                 745                 750     


<210>  4688
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRIN1__Homo_sapiens__XP_005265863

<400>  4688

Met Asp Thr Ala Glu Asp Pro Ala Trp Leu Gln Leu Leu Gln Lys Asp 
1               5                   10                  15      


Ser Ser Pro Pro Gly Pro Arg Pro Thr Ala Phe Phe Cys Pro Gln Asp 
            20                  25                  30          


Gly Ser Leu Gly Ala Gly Ser Ser Ala Met Arg Asp Tyr Cys Pro Ser 
        35                  40                  45              


Gln Gln Lys Ala Ser Pro Ala Pro Pro Arg His Thr Pro Asp Gln Ser 
    50                  55                  60                  


Pro Gly Met Glu Ser Arg His Arg Ser Pro Ser Gly Ala Gly Glu Gly 
65                  70                  75                  80  


Ala Ser Cys Ser Asp Gly Pro Arg Gly Ser Leu Ala Cys Pro Ser Pro 
                85                  90                  95      


Thr Cys Phe Ser Pro Gln Glu Ser Pro Ser Lys Glu Thr Leu Glu Ala 
            100                 105                 110         


His Gly Ala Ser Ile Ser Gly Thr Pro Glu Ala Thr Thr Ser Gly Lys 
        115                 120                 125             


Pro Glu Pro Val Ser Ser Val Lys Thr Glu Pro Lys Ser Ser Asp Asp 
    130                 135                 140                 


Arg Asn Pro Met Phe Leu Glu Lys Met Asp Phe Lys Ser Ser Lys Gln 
145                 150                 155                 160 


Ala Asp Ser Thr Ser Ile Gly Lys Glu Asp Pro Gly Ser Ser Arg Lys 
                165                 170                 175     


Ala Asp Pro Met Phe Thr Gly Lys Ala Glu Pro Glu Ile Leu Gly Lys 
            180                 185                 190         


Gly Asp Pro Val Ala Pro Gly Arg Met Asp Pro Met Thr Val Arg Lys 
        195                 200                 205             


Glu Asp Leu Gly Ser Leu Gly Lys Val Asp Pro Leu Cys Ser Ser Lys 
    210                 215                 220                 


Thr Tyr Thr Val Ser Pro Arg Lys Glu Asp Pro Gly Ser Leu Arg Lys 
225                 230                 235                 240 


Val Asp Pro Val Ser Ser Asp Lys Val Asp Pro Val Phe Pro Arg Lys 
                245                 250                 255     


Glu Glu Pro Arg Tyr Ser Gly Lys Glu His Pro Val Ser Ser Glu Lys 
            260                 265                 270         


Val Ala Pro Thr Ser Ala Glu Lys Val Asp Leu Val Leu Ser Gly Lys 
        275                 280                 285             


Arg Asp Pro Gly Pro Ser Gly Lys Ala Asp Pro Met Pro Leu Glu Ser 
    290                 295                 300                 


Met Asp Ser Ala Ser Thr Gly Lys Thr Glu Pro Gly Leu Leu Gly Lys 
305                 310                 315                 320 


Leu Ile Pro Gly Ser Ser Gly Lys Asn Gly Pro Val Ser Ser Gly Thr 
                325                 330                 335     


Gly Ala Pro Gly Ser Leu Gly Arg Leu Asp Pro Thr Cys Leu Gly Met 
            340                 345                 350         


Ala Asp Pro Ala Ser Val Gly Asn Val Glu Thr Val Pro Ala Thr Lys 
        355                 360                 365             


Glu Asp Ser Arg Phe Leu Gly Lys Met Asp Pro Ala Ser Ser Gly Glu 
    370                 375                 380                 


Gly Arg Pro Val Ser Gly His Thr Asp Thr Thr Ala Ser Ala Lys Thr 
385                 390                 395                 400 


Asp Leu Thr Ser Leu Lys Asn Val Asp Pro Met Ser Ser Gly Lys Val 
                405                 410                 415     


Asp Pro Val Ser Leu Gly Lys Met Asp Pro Met Cys Ser Gly Lys Pro 
            420                 425                 430         


Glu Leu Leu Ser Pro Gly Gln Ala Glu Arg Val Ser Val Gly Lys Ala 
        435                 440                 445             


Gly Thr Val Ser Pro Gly Lys Glu Asp Pro Val Ser Ser Arg Arg Glu 
    450                 455                 460                 


Asp Pro Ile Ser Ala Gly Ser Arg Lys Thr Ser Ser Glu Lys Val Asn 
465                 470                 475                 480 


Pro Glu Ser Ser Gly Lys Thr Asn Pro Val Ser Ser Gly Pro Gly Asp 
                485                 490                 495     


Pro Arg Ser Leu Gly Thr Ala Gly Pro Pro Ser Ala Val Lys Ala Glu 
            500                 505                 510         


Pro Ala Thr Gly Gly Lys Gly Asp Pro Leu Ser Ser Glu Lys Ala Gly 
        515                 520                 525             


Leu Val Ala Ser Gly Lys Ala Ala Pro Thr Ala Ser Gly Lys Ala Glu 
    530                 535                 540                 


Pro Leu Ala Val Gly Lys Glu Asp Pro Val Ser Lys Gly Lys Ala Asp 
545                 550                 555                 560 


Ala Gly Pro Ser Gly Gln Gly Asp Ser Val Ser Ile Gly Lys Val Val 
                565                 570                 575     


Ser Thr Pro Gly Lys Thr Val Pro Val Pro Ser Gly Lys Val Asp Pro 
            580                 585                 590         


Val Ser Leu Gly Lys Ala Glu Ala Ile Pro Glu Gly Lys Val Gly Ser 
        595                 600                 605             


Leu Pro Leu Glu Lys Gly Ser Pro Val Thr Thr Thr Lys Ala Asp Pro 
    610                 615                 620                 


Arg Ala Ser Gly Lys Ala Gln Pro Gln Ser Gly Gly Lys Ala Glu Thr 
625                 630                 635                 640 


Lys Leu Pro Gly Gln Glu Gly Ala Ala Ala Pro Gly Glu Ala Gly Ala 
                645                 650                 655     


Val Cys Leu Lys Lys Glu Thr Pro Gln Ala Ser Glu Lys Val Asp Pro 
            660                 665                 670         


Gly Ser Cys Arg Lys Ala Glu Pro Leu Ala Ser Gly Lys Gly Glu Pro 
        675                 680                 685             


Val Ser Leu Gly Lys Ala Asp Ser Ala Pro Ser Arg Lys Thr Glu Ser 
    690                 695                 700                 


Pro Ser Leu Gly Lys Val Val Pro Leu Ser Leu Glu Lys Thr Lys Pro 
705                 710                 715                 720 


Ser Ser Ser Ser Arg Gln Leu Asp Arg Lys Ala Leu Gly Ser Ala Arg 
                725                 730                 735     


Ser Pro Glu Gly Ala Arg Gly Ser Glu Gly Arg Val Glu Pro Lys Ala 
            740                 745                 750         


Glu Pro Val Ser Ser Thr Glu Ala Ser Ser Leu Gly Gln Lys Asp Leu 
        755                 760                 765             


Glu Ala Ala Gly Ala Glu Arg Ser Pro Cys Pro Glu Ala Ala Ala Pro 
    770                 775                 780                 


Pro Pro Gly Pro Arg Thr Arg Asp Asn Phe Thr Lys Ala Pro Ser Trp 
785                 790                 795                 800 


Glu Ala Ser Ala Pro Pro Pro Pro Arg Glu Asp Ala Gly Thr Gln Ala 
                805                 810                 815     


Gly Ala Gln Ala Cys Val Ser Val Ala Val Ser Pro Met Ser Pro Gln 
            820                 825                 830         


Asp Gly Ala Gly Gly Ser Ala Phe Ser Phe Gln Ala Ala Pro Arg Ala 
        835                 840                 845             


Pro Ser Pro Pro Ser Arg Arg Asp Ala Gly Leu Gln Val Ser Leu Gly 
    850                 855                 860                 


Ala Ala Glu Thr Arg Ser Val Ala Thr Gly Pro Met Thr Pro Gln Ala 
865                 870                 875                 880 


Ala Ala Pro Pro Ala Phe Pro Glu Val Arg Val Arg Pro Gly Ser Ala 
                885                 890                 895     


Leu Ala Ala Ala Val Ala Pro Pro Glu Pro Ala Glu Pro Val Arg Asp 
            900                 905                 910         


Val Ser Trp Asp Glu Lys Gly Met Thr Trp Glu Val Tyr Gly Ala Ala 
        915                 920                 925             


Met Glu Val Glu Val Leu Gly Met Ala Ile Gln Lys His Leu Glu Arg 
    930                 935                 940                 


Gln Ile Glu Glu His Gly Arg Gln Gly Ala Pro Ala Pro Pro Pro Ala 
945                 950                 955                 960 


Ala Arg Ala Gly Pro Gly Arg Ser Gly Ser Val Arg Thr Ala Pro Pro 
                965                 970                 975     


Asp Gly Ala Ala Lys Arg Pro Pro Gly Leu Phe Arg Ala Leu Leu Gln 
            980                 985                 990         


Ser Val Arg Arg Pro Arg Cys Cys  Ser Arg Ala Gly Pro  Thr Ala Glu 
        995                 1000                 1005             


<210>  4689
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRIN2__Homo_sapiens__XP_011538700

<400>  4689

Met Leu Asn Glu Ser Leu Met Glu Lys Ala Asp Ala Trp Gly Leu Ser 
1               5                   10                  15      


Leu Pro Leu Glu Leu Glu Ala Ala Met Ser Ser Ser Arg Pro Glu Pro 
            20                  25                  30          


Gly Pro Trp Ala Pro Leu Ser Pro Arg Leu Gln Pro Leu Ser Gln Ser 
        35                  40                  45              


Ser Ser Ser Leu Leu Gly Glu Gly Arg Glu Gln Arg Pro Glu Leu Arg 
    50                  55                  60                  


Lys Thr Ala Ser Ser Thr Val Trp Gln Ala Gln Leu Gly Glu Ala Ser 
65                  70                  75                  80  


Thr Arg Pro Gln Ala Pro Glu Glu Glu Gly Asn Pro Pro Glu Ser Met 
                85                  90                  95      


Lys Pro Ala Arg Ala Ser Gly Pro Lys Ala Arg Pro Ser Ala Gly Gly 
            100                 105                 110         


His Trp Trp Ser Ser Thr Val Gly Asn Val Ser Thr Met Gly Gly Ser 
        115                 120                 125             


Asp Leu Cys Arg Leu Arg Ala Pro Ser Ala Ala Ala Met Gln Arg Ser 
    130                 135                 140                 


His Ser Asp Leu Val Arg Ser Thr Gln Met Arg Gly His Ser Gly Ala 
145                 150                 155                 160 


Arg Lys Ala Ser Leu Ser Cys Ser Ala Leu Gly Ser Ser Pro Val His 
                165                 170                 175     


Arg Ala Gln Leu Gln Pro Gly Gly Thr Ser Gly Gln Gly Gly Gln Ala 
            180                 185                 190         


Pro Ala Gly Leu Glu Arg Asp Leu Ala Pro Glu Asp Glu Thr Ser Asn 
        195                 200                 205             


Ser Ala Trp Met Leu Gly Ala Ser Gln Leu Ser Val Pro Pro Leu Asp 
    210                 215                 220                 


Leu Gly Asp Thr Thr Ala His Ser Ser Ser Ala Gln Ala Glu Pro Lys 
225                 230                 235                 240 


Ala Ala Glu Gln Leu Ala Thr Thr Thr Cys His Ala Leu Pro Pro Ala 
                245                 250                 255     


Ala Leu Leu Cys Gly Met Arg Glu Val Arg Ala Gly Gly Cys Cys His 
            260                 265                 270         


Ala Leu Pro Ala Thr Gly Ile Leu Ala Phe Pro Lys Leu Val Ala Ser 
        275                 280                 285             


Val Ser Glu Ser Gly Leu Gln Ala Gln His Gly Val Lys Ile His Cys 
    290                 295                 300                 


Arg Leu Ser Gly Gly Leu Pro Gly His Ser His Cys Cys Ala His Leu 
305                 310                 315                 320 


Trp Gly Pro Ala Gly Leu Val Pro Glu Pro Gly Ser Arg Thr Lys Asp 
                325                 330                 335     


Val Trp Thr Met Thr Ser Ala Asn Asp Leu Ala Pro Ala Glu Ala Ser 
            340                 345                 350         


Pro Leu Ser Ala Gln Asp Ala Gly Val Gln Ala Ala Pro Val Ala Ala 
        355                 360                 365             


Cys Lys Ala Val Ala Thr Ser Pro Ser Leu Glu Ala Pro Ala Ala Leu 
    370                 375                 380                 


His Val Phe Pro Glu Val Thr Leu Gly Ser Ser Leu Glu Glu Val Pro 
385                 390                 395                 400 


Ser Pro Val Arg Asp Val Arg Trp Asp Ala Glu Gly Met Thr Trp Glu 
                405                 410                 415     


Val Tyr Gly Ala Ala Val Asp Leu Glu Val Leu Gly Val Ala Ile Gln 
            420                 425                 430         


Lys His Leu Glu Met Gln Phe Glu Gln Leu Gln Arg Ala Pro Ala Ser 
        435                 440                 445             


Glu Asp Ser Leu Ser Val Glu Gly Arg Arg Gly Pro Leu Arg Ala Val 
    450                 455                 460                 


Met Gln Ser Leu Arg Arg Pro Ser Cys Cys Gly Cys Ser Gly Ala Ala 
465                 470                 475                 480 


Pro Glu 
        


<210>  4690
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPRIN3__Homo_sapiens__XP_005262993

<400>  4690

Met Gly Thr Val Pro Asp Pro Leu Arg Ser Ala Lys Thr Ser Leu Ile 
1               5                   10                  15      


Ala Ala Ser Gly Lys Glu Asp Asp Leu Gly Glu Pro Gln Ala Ala Ser 
            20                  25                  30          


Pro Arg His Arg Pro Ala Leu Leu Cys Lys Asn Ala Asn Gly Phe Ser 
        35                  40                  45              


Gly Ala Pro Ala Glu Pro Asp Leu Ser Pro Arg Ala Ala Ala Glu Ala 
    50                  55                  60                  


Leu Met Gln Val Cys Glu His Glu Thr Thr Gln Pro Asp Met Ser Ser 
65                  70                  75                  80  


Pro Gly Val Phe Asn Glu Val Gln Lys Ala Pro Ala Thr Phe Asn Ser 
                85                  90                  95      


Pro Gly Asn Pro Gln Leu Pro Gly Ser Ser Gln Pro Ala Ala Ser Ala 
            100                 105                 110         


Pro Ser Ser Ala Ala Gly Arg Asp Leu Ile His Thr Pro Leu Thr Met 
        115                 120                 125             


Pro Ala Asn Gln His Thr Cys Gln Ser Ile Pro Gly Asp Gln Pro Asn 
    130                 135                 140                 


Ala Ile Thr Ser Ser Met Pro Glu Asp Ser Leu Met Arg Ser Gln Arg 
145                 150                 155                 160 


Thr Ser Asn Arg Glu Gln Pro Glu Lys Pro Ser Cys Pro Val Gly Gly 
                165                 170                 175     


Val Leu Ser Ser Ser Lys Asp Gln Val Ser Cys Glu Phe Pro Ser Pro 
            180                 185                 190         


Glu Thr Ile Gln Gly Thr Val Gln Thr Pro Val Thr Ala Ala Arg Val 
        195                 200                 205             


Val Ser His Ser Ser Ser Pro Val Gly Gly Pro Glu Gly Glu Arg Gln 
    210                 215                 220                 


Gly Ala Ile Cys Asp Ser Glu Met Arg Ser Cys Lys Pro Leu Thr Arg 
225                 230                 235                 240 


Glu Ser Gly Cys Ser Glu Asn Lys Gln Pro Ser Val Thr Ala Ser Gly 
                245                 250                 255     


Pro Gln Gly Thr Thr Ser Val Thr Pro Gln Pro Thr Pro Leu Thr Ser 
            260                 265                 270         


Glu Pro Ser Ala Cys Pro Pro Gly Pro Glu Lys Val Pro Leu Pro Ala 
        275                 280                 285             


Gln Arg Gln Met Ser Arg Phe Lys Glu Ala Ser Thr Met Thr Asn Gln 
    290                 295                 300                 


Ala Glu Ser Glu Ile Lys Glu Val Pro Ser Arg Ala Trp Gln Asp Ala 
305                 310                 315                 320 


Glu Val Gln Ala Val Ala Ser Val Glu Ser Arg Ser Val Ser Thr Ser 
                325                 330                 335     


Pro Ser Ile Leu Thr Ala Phe Leu Lys Glu Ser Arg Ala Pro Glu His 
            340                 345                 350         


Phe Glu Gln Glu Gln Leu Arg Val Ile Cys His Ser Ser Gly Ser His 
        355                 360                 365             


Thr Leu Glu Leu Ser Asp Ser Thr Leu Ala Pro Gln Glu Ser Ser Gln 
    370                 375                 380                 


Cys Pro Gly Ile Met Pro Gln Val His Ile Gln Ala Ala Ala Ala Glu 
385                 390                 395                 400 


Ser Thr Ala Phe Gln Arg Glu Asn Lys Leu Ala Ser Leu Pro Gly Gly 
                405                 410                 415     


Val Leu Lys Thr Ser Ser Ile Asn Leu Val Ser Ser Asn Ala Gln His 
            420                 425                 430         


Thr Cys Lys Glu Asp Gly Arg Leu Ala Gly Met Thr Pro Val Arg Glu 
        435                 440                 445             


Glu Ser Thr Ala Lys Lys Leu Ala Gly Thr Asn Ser Ser Ser Leu Lys 
    450                 455                 460                 


Ala Thr Ala Ile Asp Gln Ile Ser Ile Ser Ala Cys Ser Gln Ala Glu 
465                 470                 475                 480 


Thr Ser Tyr Gly Leu Gly Lys Phe Glu Thr Arg Pro Ser Glu Phe Ala 
                485                 490                 495     


Glu Lys Thr Thr Asn Gly His Lys Thr Asp Pro Asp Cys Lys Leu Ser 
            500                 505                 510         


Asp Ser Cys Gly Ser Ile Ser Lys Ala Asp His Ser Gly Ser Leu Asp 
        515                 520                 525             


Pro Thr Asn Lys Gly Asp Ala Arg Glu Lys Lys Pro Ala Ser Pro Gln 
    530                 535                 540                 


Val Val Lys Glu Lys Glu Ser Thr Gly Thr Asp Thr Ser Asp Ala Lys 
545                 550                 555                 560 


Thr Leu Leu Leu Asn Pro Lys Ser Gln Glu Ser Gly Gly Thr Glu Ser 
                565                 570                 575     


Ala Ala Asn Pro Thr Pro Ser Pro Ile Arg Lys Asn Gln Glu Ser Thr 
            580                 585                 590         


Leu Glu Glu Asn Arg Gln Thr Lys Thr Ala Thr Ser Leu Ser Leu Pro 
        595                 600                 605             


Ser Asp Pro Met Gly Asp Ser Ser Pro Gly Ser Gly Lys Lys Thr Pro 
    610                 615                 620                 


Ser Arg Ser Val Lys Ala Ser Pro Arg Arg Pro Ser Arg Val Ser Glu 
625                 630                 635                 640 


Phe Leu Lys Glu Gln Lys Leu Asn Val Thr Ala Ala Ala Ala Gln Val 
                645                 650                 655     


Gly Leu Thr Pro Gly Asp Lys Lys Lys Gln Leu Gly Ala Asp Ser Lys 
            660                 665                 670         


Leu Gln Leu Lys Gln Ser Lys Arg Val Arg Asp Val Val Trp Asp Glu 
        675                 680                 685             


Gln Gly Met Thr Trp Glu Val Tyr Gly Ala Ser Leu Asp Ala Glu Ser 
    690                 695                 700                 


Leu Gly Ile Ala Ile Gln Asn His Leu Gln Arg Gln Ile Arg Glu His 
705                 710                 715                 720 


Glu Lys Leu Ile Lys Thr Gln Asn Ser Gln Thr Arg Arg Ser Ile Ser 
                725                 730                 735     


Ser Asp Thr Ser Ser Asn Lys Lys Leu Arg Gly Arg Gln His Ser Val 
            740                 745                 750         


Phe Gln Ser Met Leu Gln Asn Phe Arg Arg Pro Asn Cys Cys Val Arg 
        755                 760                 765             


Pro Ala Pro Ser Ser Val Leu Asp 
    770                 775     


<210>  4691
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPS2__Homo_sapiens__NP_004480

<400>  4691

Met Pro Ala Leu Leu Glu Arg Pro Lys Leu Ser Asn Ala Met Ala Arg 
1               5                   10                  15      


Ala Leu His Arg His Ile Met Met Glu Arg Glu Arg Lys Arg Gln Glu 
            20                  25                  30          


Glu Glu Glu Val Asp Lys Met Met Glu Gln Lys Met Lys Glu Glu Gln 
        35                  40                  45              


Glu Arg Arg Lys Lys Lys Glu Met Glu Glu Arg Met Ser Leu Glu Glu 
    50                  55                  60                  


Thr Lys Glu Gln Ile Leu Lys Leu Glu Glu Lys Leu Leu Ala Leu Gln 
65                  70                  75                  80  


Glu Glu Lys His Gln Leu Phe Leu Gln Leu Lys Lys Val Leu His Glu 
                85                  90                  95      


Glu Glu Lys Arg Arg Arg Lys Glu Gln Ser Asp Leu Thr Thr Leu Thr 
            100                 105                 110         


Ser Ala Ala Tyr Gln Gln Ser Leu Thr Val His Thr Gly Thr His Leu 
        115                 120                 125             


Leu Ser Met Gln Gly Ser Pro Gly Gly His Asn Arg Pro Gly Thr Leu 
    130                 135                 140                 


Met Ala Ala Asp Arg Ala Lys Gln Met Phe Gly Pro Gln Val Leu Thr 
145                 150                 155                 160 


Thr Arg His Tyr Val Gly Ser Ala Ala Ala Phe Ala Gly Thr Pro Glu 
                165                 170                 175     


His Gly Gln Phe Gln Gly Ser Pro Gly Gly Ala Tyr Gly Thr Ala Gln 
            180                 185                 190         


Pro Pro Pro His Tyr Gly Pro Thr Gln Pro Ala Tyr Ser Pro Ser Gln 
        195                 200                 205             


Gln Leu Arg Ala Pro Ser Ala Phe Pro Ala Val Gln Tyr Leu Ser Gln 
    210                 215                 220                 


Pro Gln Pro Gln Pro Tyr Ala Val His Gly His Phe Gln Pro Thr Gln 
225                 230                 235                 240 


Thr Gly Phe Leu Gln Pro Gly Gly Ala Leu Ser Leu Gln Lys Gln Met 
                245                 250                 255     


Glu His Ala Asn Gln Gln Thr Gly Phe Ser Asp Ser Ser Ser Leu Arg 
            260                 265                 270         


Pro Met His Pro Gln Ala Leu His Pro Ala Pro Gly Leu Leu Ala Ser 
        275                 280                 285             


Pro Gln Leu Pro Val Gln Met Gln Pro Ala Gly Lys Ser Gly Phe Ala 
    290                 295                 300                 


Ala Thr Ser Gln Pro Gly Pro Arg Leu Pro Phe Ile Gln His Ser Gln 
305                 310                 315                 320 


Asn Pro Arg Phe Tyr His Lys 
                325         


<210>  4692
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPSM1__Homo_sapiens__NP_001139110

<400>  4692

Met Ala Gly Pro Ala Pro Pro Ala Ala Asp Glu Leu Pro Gly Pro Ala 
1               5                   10                  15      


Ala Arg Arg Leu Tyr Ser Arg Met Glu Ala Ser Cys Leu Glu Leu Ala 
            20                  25                  30          


Leu Glu Gly Glu Arg Leu Cys Lys Ala Gly Asp Phe Lys Thr Gly Val 
        35                  40                  45              


Ala Phe Phe Glu Ala Ala Val Gln Val Gly Thr Glu Asp Leu Lys Thr 
    50                  55                  60                  


Leu Ser Ala Ile Tyr Ser Gln Leu Gly Asn Ala Tyr Phe Tyr Leu Lys 
65                  70                  75                  80  


Glu His Gly Arg Ala Leu Glu Tyr His Lys His Asp Leu Leu Leu Ala 
                85                  90                  95      


Arg Thr Ile Gly Asp Arg Met Gly Glu Ala Lys Ala Ser Gly Asn Leu 
            100                 105                 110         


Gly Asn Thr Leu Lys Val Leu Gly Arg Phe Asp Glu Ala Ala Val Cys 
        115                 120                 125             


Cys Gln Arg His Leu Ser Ile Ala Gln Glu Gln Gly Asp Lys Val Gly 
    130                 135                 140                 


Glu Ala Arg Ala Leu Tyr Asn Ile Gly Asn Val Tyr His Ala Lys Gly 
145                 150                 155                 160 


Lys Gln Leu Ser Trp Asn Ala Ala Asn Ala Thr Gln Asp Pro Gly His 
                165                 170                 175     


Leu Pro Pro Asp Val Arg Glu Thr Leu Cys Lys Ala Ser Glu Phe Tyr 
            180                 185                 190         


Glu Arg Asn Leu Ser Leu Val Lys Glu Leu Gly Asp Arg Ala Ala Gln 
        195                 200                 205             


Gly Arg Ala Tyr Gly Asn Leu Gly Asn Thr His Tyr Leu Leu Gly Asn 
    210                 215                 220                 


Phe Thr Glu Ala Thr Thr Phe His Lys Glu Arg Leu Ala Ile Ala Lys 
225                 230                 235                 240 


Glu Phe Gly Asp Lys Ala Ala Glu Arg Arg Ala Tyr Ser Asn Leu Gly 
                245                 250                 255     


Asn Ala His Val Phe Leu Gly Arg Phe Asp Val Ala Ala Glu Tyr Tyr 
            260                 265                 270         


Lys Lys Thr Leu Gln Leu Ser Arg Gln Leu Arg Asp Gln Ala Val Glu 
        275                 280                 285             


Ala Gln Ala Cys Tyr Ser Leu Gly Asn Thr Tyr Thr Leu Leu Gln Asp 
    290                 295                 300                 


Tyr Glu Arg Ala Ala Glu Tyr His Leu Arg His Leu Leu Ile Ala Gln 
305                 310                 315                 320 


Glu Leu Ala Asp Arg Val Gly Glu Gly Arg Ala Cys Trp Ser Leu Gly 
                325                 330                 335     


Asn Ala Tyr Val Ser Met Gly Arg Pro Ala Gln Ala Leu Thr Phe Ala 
            340                 345                 350         


Lys Lys His Leu Gln Ile Ser Gln Glu Ile Gly Asp Arg His Gly Glu 
        355                 360                 365             


Leu Thr Ala Arg Met Asn Val Ala Gln Leu Gln Leu Val Leu Gly Arg 
    370                 375                 380                 


Leu Thr Ser Pro Ala Ala Ser Glu Lys Pro Asp Leu Ala Gly Tyr Glu 
385                 390                 395                 400 


Ala Gln Gly Ala Arg Pro Lys Arg Thr Gln Arg Leu Ser Ala Glu Thr 
                405                 410                 415     


Trp Asp Leu Leu Arg Leu Pro Leu Glu Arg Glu Gln Asn Gly Asp Ser 
            420                 425                 430         


His His Ser Gly Asp Trp Arg Gly Pro Ser Arg Asp Ser Leu Pro Leu 
        435                 440                 445             


Pro Val Arg Ser Arg Lys Tyr Gln Glu Gly Pro Asp Ala Glu Arg Arg 
    450                 455                 460                 


Pro Arg Glu Gly Ser His Ser Pro Leu Asp Ser Ala Asp Val Arg Val 
465                 470                 475                 480 


His Val Pro Arg Thr Ser Ile Pro Arg Ala Pro Ser Ser Asp Glu Glu 
                485                 490                 495     


Cys Phe Phe Asp Leu Leu Thr Lys Phe Gln Ser Ser Arg Met Asp Asp 
            500                 505                 510         


Gln Arg Cys Pro Leu Asp Asp Gly Gln Ala Gly Ala Ala Glu Ala Thr 
        515                 520                 525             


Ala Ala Pro Thr Leu Glu Asp Arg Ile Ala Gln Pro Ser Met Thr Ala 
    530                 535                 540                 


Ser Pro Gln Thr Glu Glu Phe Phe Asp Leu Ile Ala Ser Ser Gln Ser 
545                 550                 555                 560 


Arg Arg Leu Asp Asp Gln Arg Ala Ser Val Gly Ser Leu Pro Gly Leu 
                565                 570                 575     


Arg Ile Thr His Ser Asn Ala Gly His Leu Arg Gly His Gly Glu Pro 
            580                 585                 590         


Gln Glu Pro Gly Asp Asp Phe Phe Asn Met Leu Ile Lys Tyr Gln Ser 
        595                 600                 605             


Ser Arg Ile Asp Asp Gln Arg Cys Pro Pro Pro Asp Val Leu Pro Arg 
    610                 615                 620                 


Gly Pro Thr Met Pro Asp Glu Asp Phe Phe Ser Leu Ile Gln Arg Val 
625                 630                 635                 640 


Gln Ala Lys Arg Met Asp Glu Gln Arg Val Asp Leu Ala Gly Gly Pro 
                645                 650                 655     


Glu Gln Gly Ala Gly Gly Pro Pro Glu Pro Gln Gln Gln Cys Gln Pro 
            660                 665                 670         


Gly Ala Ser 
        675 


<210>  4693
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPSM2__Homo_sapiens__XP_011539605

<400>  4693

Met Glu Glu Asn Leu Ile Ser Met Arg Glu Asp His Ser Phe His Val 
1               5                   10                  15      


Arg Tyr Arg Met Glu Ala Ser Cys Leu Glu Leu Ala Leu Glu Gly Glu 
            20                  25                  30          


Arg Leu Cys Lys Ser Gly Asp Cys Arg Ala Gly Val Ser Phe Phe Glu 
        35                  40                  45              


Ala Ala Val Gln Val Gly Thr Glu Asp Leu Lys Thr Leu Ser Ala Ile 
    50                  55                  60                  


Tyr Ser Gln Leu Gly Asn Ala Tyr Phe Tyr Leu His Asp Tyr Ala Lys 
65                  70                  75                  80  


Ala Leu Glu Tyr His His His Asp Leu Thr Leu Ala Arg Thr Ile Gly 
                85                  90                  95      


Asp Gln Leu Gly Glu Ala Lys Ala Ser Gly Asn Leu Gly Asn Thr Leu 
            100                 105                 110         


Lys Val Leu Gly Asn Phe Asp Glu Ala Ile Val Cys Cys Gln Arg His 
        115                 120                 125             


Leu Asp Ile Ser Arg Glu Leu Asn Asp Lys Val Gly Glu Ala Arg Ala 
    130                 135                 140                 


Leu Tyr Asn Leu Gly Asn Val Tyr His Ala Lys Gly Lys Ser Phe Gly 
145                 150                 155                 160 


Cys Pro Gly Pro Gln Asp Val Gly Glu Phe Pro Glu Glu Val Arg Asp 
                165                 170                 175     


Ala Leu Gln Ala Ala Val Asp Phe Tyr Glu Glu Asn Leu Ser Leu Val 
            180                 185                 190         


Thr Ala Leu Gly Asp Arg Ala Ala Gln Gly Arg Ala Phe Gly Asn Leu 
        195                 200                 205             


Gly Asn Thr His Tyr Leu Leu Gly Asn Phe Arg Asp Ala Val Ile Ala 
    210                 215                 220                 


His Glu Gln Arg Leu Leu Ile Ala Lys Glu Phe Gly Asp Lys Ala Ala 
225                 230                 235                 240 


Glu Arg Arg Ala Tyr Ser Asn Leu Gly Asn Ala Tyr Ile Phe Leu Gly 
                245                 250                 255     


Glu Phe Glu Thr Ala Ser Glu Tyr Tyr Lys Lys Thr Leu Leu Leu Ala 
            260                 265                 270         


Arg Gln Leu Lys Asp Arg Ala Val Glu Ala Gln Ser Cys Tyr Ser Leu 
        275                 280                 285             


Gly Asn Thr Tyr Thr Leu Leu Gln Asp Tyr Glu Lys Ala Ile Asp Tyr 
    290                 295                 300                 


His Leu Lys His Leu Ala Ile Ala Gln Glu Leu Asn Asp Arg Ile Gly 
305                 310                 315                 320 


Glu Gly Arg Ala Cys Trp Ser Leu Gly Asn Ala Tyr Thr Ala Leu Gly 
                325                 330                 335     


Asn His Asp Gln Ala Met His Phe Ala Glu Lys His Leu Glu Ile Ser 
            340                 345                 350         


Arg Glu Val Gly Asp Lys Ser Gly Glu Leu Thr Ala Arg Leu Asn Leu 
        355                 360                 365             


Ser Asp Leu Gln Met Val Leu Gly Leu Ser Tyr Ser Thr Asn Asn Ser 
    370                 375                 380                 


Ile Met Ser Glu Asn Thr Glu Ile Asp Ser Ser Leu Asn Gly Val Arg 
385                 390                 395                 400 


Pro Lys Leu Gly Arg Arg His Ser Met Glu Asn Met Glu Leu Met Lys 
                405                 410                 415     


Leu Thr Pro Glu Lys Val Leu Lys Asn Gln His Phe Asn Val Leu Ile 
            420                 425                 430         


Met Arg Ile His Ser Met His Leu Val Gln Val Leu Lys Ile Val Gln 
        435                 440                 445             


Tyr Thr Lys Lys Asp Ile Phe Lys Glu Ile 
    450                 455             


<210>  4694
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPSM3__Homo_sapiens__NP_071390

<400>  4694

Met Glu Ala Glu Arg Pro Gln Glu Glu Glu Asp Gly Glu Gln Gly Pro 
1               5                   10                  15      


Pro Gln Asp Glu Glu Gly Trp Pro Pro Pro Asn Ser Thr Thr Arg Pro 
            20                  25                  30          


Trp Arg Ser Ala Pro Pro Ser Pro Pro Pro Pro Gly Thr Arg His Thr 
        35                  40                  45              


Ala Leu Gly Pro Arg Ser Ala Ser Leu Leu Ser Leu Gln Thr Glu Leu 
    50                  55                  60                  


Leu Leu Asp Leu Val Ala Glu Ala Gln Ser Arg Arg Leu Glu Glu Gln 
65                  70                  75                  80  


Arg Ala Thr Phe Tyr Thr Pro Gln Asn Pro Ser Ser Leu Ala Pro Ala 
                85                  90                  95      


Pro Leu Arg Pro Leu Glu Asp Arg Glu Gln Leu Tyr Ser Thr Ile Leu 
            100                 105                 110         


Ser His Gln Cys Gln Arg Met Glu Ala Gln Arg Ser Glu Pro Pro Leu 
        115                 120                 125             


Pro Pro Gly Gly Gln Glu Leu Leu Glu Leu Leu Leu Arg Val Gln Gly 
    130                 135                 140                 


Gly Gly Arg Met Glu Glu Gln Arg Ser Arg Pro Pro Thr His Thr Cys 
145                 150                 155                 160 


<210>  4695
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPT2__Homo_sapiens__NP_001135938

<400>  4695

Met Gly Gln Gln Pro Ile Thr Phe Leu Arg Gln Val Met Ala Leu Cys 
1               5                   10                  15      


Thr Tyr Pro Asn Leu Leu Asp Ser Pro Ser Phe Pro Glu Asp Ala Lys 
            20                  25                  30          


Lys Arg Ala Arg Arg Ile Leu Gln Ala Cys Gly Gly Asn Ser Leu Gly 
        35                  40                  45              


Ser Tyr Ser Ala Ser Gln Gly Val Asn Cys Ile Arg Glu Asp Val Ala 
    50                  55                  60                  


Ala Tyr Ile Thr Arg Arg Asp Gly Gly Val Pro Ala Asp Pro Asp Asn 
65                  70                  75                  80  


Ile Tyr Leu Thr Thr Gly Ala Ser Asp Gly Ile Ser Thr Ile Leu Lys 
                85                  90                  95      


Ile Leu Val Ser Gly Gly Gly Lys Ser Arg Thr Gly Val Met Ile Pro 
            100                 105                 110         


Ile Pro Gln Tyr Pro Leu Tyr Ser Ala Val Ile Ser Glu Leu Asp Ala 
        115                 120                 125             


Ile Gln Val Asn Tyr Tyr Leu Asp Glu Glu Asn Cys Trp Ala Leu Asn 
    130                 135                 140                 


Val Asn Glu Leu Arg Arg Ala Val Gln Glu Ala Lys Asp His Cys Asp 
145                 150                 155                 160 


Pro Lys Val Leu Cys Ile Ile Asn Pro Gly Asn Pro Thr Gly Gln Val 
                165                 170                 175     


Gln Ser Arg Lys Cys Ile Glu Asp Val Ile His Phe Ala Trp Glu Glu 
            180                 185                 190         


Lys Leu Phe Leu Leu Ala Asp Glu Val Tyr Gln Asp Asn Val Tyr Ser 
        195                 200                 205             


Pro Asp Cys Arg Phe His Ser Phe Lys Lys Val Leu Tyr Glu Met Gly 
    210                 215                 220                 


Pro Glu Tyr Ser Ser Asn Val Glu Leu Ala Ser Phe His Ser Thr Ser 
225                 230                 235                 240 


Lys Gly Tyr Met Gly Glu Cys Gly Tyr Arg Gly Gly Tyr Met Glu Val 
                245                 250                 255     


Ile Asn Leu His Pro Glu Ile Lys Gly Gln Leu Val Lys Leu Leu Ser 
            260                 265                 270         


Val Arg Leu Cys Pro Pro Val Ser Gly Gln Ala Ala Met Asp Ile Val 
        275                 280                 285             


Val Asn Pro Pro Val Ala Gly Glu Glu Ser Phe Glu Gln Phe Ser Arg 
    290                 295                 300                 


Glu Lys Glu Ser Val Leu Gly Asn Leu Ala Lys Lys Ala Lys Leu Thr 
305                 310                 315                 320 


Glu Asp Leu Phe Asn Gln Val Pro Gly Ile His Cys Asn Pro Leu Gln 
                325                 330                 335     


Gly Ala Met Tyr Ala Phe Pro Arg Ile Phe Ile Pro Ala Lys Ala Val 
            340                 345                 350         


Glu Ala Ala Gln Ala His Gln Met Ala Pro Asp Met Phe Tyr Cys Met 
        355                 360                 365             


Lys Leu Leu Glu Glu Thr Gly Ile Cys Val Val Pro Gly Ser Gly Phe 
    370                 375                 380                 


Gly Gln Arg Glu Gly Thr Tyr His Phe Arg Met Thr Ile Leu Pro Pro 
385                 390                 395                 400 


Val Glu Lys Leu Lys Thr Val Leu Gln Lys Val Lys Asp Phe His Ile 
                405                 410                 415     


Asn Phe Leu Glu Lys Tyr Ala 
            420             


<210>  4696
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPT__Homo_sapiens__XP_011515295

<400>  4696

Met Ala Ser Ser Thr Gly Asp Arg Ser Gln Ala Val Arg His Gly Leu 
1               5                   10                  15      


Arg Ala Lys Val Leu Thr Leu Asp Gly Met Asn Pro Arg Val Arg Arg 
            20                  25                  30          


Val Glu Tyr Ala Val Arg Gly Pro Ile Val Gln Arg Ala Leu Glu Leu 
        35                  40                  45              


Glu Gln Glu Leu Arg Gln Gly Val Lys Lys Pro Phe Thr Glu Val Ile 
    50                  55                  60                  


Arg Ala Asn Ile Gly Asp Ala Gln Ala Met Gly Gln Arg Pro Ile Thr 
65                  70                  75                  80  


Phe Leu Arg Gln Val Leu Ala Leu Cys Val Asn Pro Asp Leu Leu Ser 
                85                  90                  95      


Ser Pro Asn Phe Pro Asp Asp Ala Lys Lys Arg Ala Glu Arg Ile Leu 
            100                 105                 110         


Gln Ala Cys Gly Gly His Ser Leu Gly Ala Tyr Ser Val Ser Ser Gly 
        115                 120                 125             


Ile Gln Leu Ile Arg Glu Asp Val Ala Arg Tyr Ile Glu Arg Arg Asp 
    130                 135                 140                 


Gly Gly Ile Pro Ala Asp Pro Asn Asn Val Phe Leu Ser Thr Gly Ala 
145                 150                 155                 160 


Ser Asp Ala Ile Val Thr Val Leu Lys Leu Leu Val Ala Gly Glu Gly 
                165                 170                 175     


His Thr Arg Thr Gly Val Leu Ile Pro Ile Pro Gln Tyr Pro Leu Tyr 
            180                 185                 190         


Ser Ala Thr Leu Ala Glu Leu Gly Ala Val Gln Val Asp Tyr Tyr Leu 
        195                 200                 205             


Asp Glu Glu Arg Ala Trp Ala Leu Asp Val Ala Glu Leu His Arg Ala 
    210                 215                 220                 


Leu Gly Gln Ala Arg Asp His Cys Arg Pro Arg Ala Leu Cys Val Ile 
225                 230                 235                 240 


Asn Pro Gly Asn Pro Thr Gly Gln Val Gln Thr Arg Glu Cys Ile Glu 
                245                 250                 255     


Ala Val Ile Arg Phe Ala Phe Glu Glu Arg Leu Phe Leu Leu Ala Asp 
            260                 265                 270         


Glu Val Tyr Gln Asp Asn Val Tyr Ala Ala Gly Ser Gln Phe His Ser 
        275                 280                 285             


Phe Lys Lys Val Leu Met Glu Met Gly Pro Pro Tyr Ala Gly Gln Gln 
    290                 295                 300                 


Glu Leu Ala Ser Phe His Ser Thr Ser Lys Gly Tyr Met Gly Glu Cys 
305                 310                 315                 320 


Gly Phe Arg Gly Gly Tyr Val Glu Val Val Asn Met Asp Ala Ala Val 
                325                 330                 335     


Gln Gln Gln Met Leu Lys Leu Met Ser Val Arg Leu Cys Pro Pro Val 
            340                 345                 350         


Pro Gly Gln Ala Leu Leu Asp Leu Val Val Ser Pro Pro Ala Pro Thr 
        355                 360                 365             


Asp Pro Ser Phe Ala Gln Phe Gln Ala Glu Lys Gln Ala Val Leu Ala 
    370                 375                 380                 


Glu Leu Ala Ala Lys Ala Lys Leu Thr Glu Gln Val Phe Asn Glu Ala 
385                 390                 395                 400 


Pro Gly Ile Ser Cys Asn Pro Val Gln Gly Ala Met Tyr Ser Phe Pro 
                405                 410                 415     


Arg Val Gln Leu Pro Pro Arg Ala Val Glu Arg Ala Gln Glu Leu Gly 
            420                 425                 430         


Leu Ala Pro Asp Met Phe Phe Cys Leu Arg Leu Leu Glu Glu Thr Gly 
        435                 440                 445             


Ile Cys Val Val Pro Gly Ser Gly Phe Gly Gln Arg Glu Gly Thr Tyr 
    450                 455                 460                 


His Phe Arg Met Thr Ile Leu Pro Pro Leu Glu Lys Leu Arg Leu Leu 
465                 470                 475                 480 


Leu Glu Lys Leu Ser Arg Phe His Ala Lys Phe Thr Leu Glu Tyr Ser 
                485                 490                 495     


<210>  4697
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPX5__Homo_sapiens__NP_001500

<400>  4697

Met Thr Thr Gln Leu Arg Val Val His Leu Leu Pro Leu Leu Leu Ala 
1               5                   10                  15      


Cys Phe Val Gln Thr Ser Pro Lys Gln Glu Lys Met Lys Met Asp Cys 
            20                  25                  30          


His Lys Asp Glu Lys Gly Thr Ile Tyr Asp Tyr Glu Ala Ile Ala Leu 
        35                  40                  45              


Asn Lys Asn Glu Tyr Val Ser Phe Lys Gln Tyr Val Gly Lys His Ile 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Thr Tyr Cys Gly Leu Thr Ala Gln Tyr Pro 
65                  70                  75                  80  


Glu Leu Asn Ala Leu Gln Glu Glu Leu Lys Pro Tyr Gly Leu Val Val 
                85                  90                  95      


Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Asp Asn 
            100                 105                 110         


Lys Glu Ile Leu Pro Gly Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
        115                 120                 125             


Val Pro Ser Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
    130                 135                 140                 


Glu Gln Lys Val Phe Ser Phe Leu Lys His Ser Cys Pro His Pro Ser 
145                 150                 155                 160 


Glu Ile Leu Gly Thr Phe Lys Ser Ile Ser Trp Asp Pro Val Lys Val 
                165                 170                 175     


His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
            180                 185                 190         


Ile Pro Val Met Arg Trp Ser His Arg Ala Thr Val Ser Ser Val Lys 
        195                 200                 205             


Thr Asp Ile Leu Ala Tyr Leu Lys Gln Phe Lys Thr Lys 
    210                 215                 220     


<210>  4698
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAMD1B__Homo_sapiens__NP_001273492

<400>  4698

Met Lys Gly Phe Lys Leu Ser Cys Thr Ala Ser Asn Ser Asn Arg Ser 
1               5                   10                  15      


Thr Pro Ala Cys Ser Pro Ile Leu Arg Lys Arg Ser Arg Ser Pro Thr 
            20                  25                  30          


Pro Gln Asn Gln Asp Gly Asp Thr Met Val Glu Lys Gly Ser Asp His 
        35                  40                  45              


Ser Ser Asp Lys Ser Pro Ser Thr Pro Glu Gln Gly Val Gln Arg Ser 
    50                  55                  60                  


Cys Ser Ser Gln Ser Gly Arg Ser Gly Gly Lys Asn Ser Lys Ser His 
65                  70                  75                  80  


Lys Arg Leu Ser Lys Lys Ser Gln Ser Trp Tyr Asn Val Leu Ser Pro 
                85                  90                  95      


Thr Tyr Lys Gln Arg Asn Glu Asp Phe Arg Lys Leu Phe Lys Gln Leu 
            100                 105                 110         


Pro Asp Thr Glu Arg Leu Ile Val Asp Tyr Ser Cys Ala Leu Gln Arg 
        115                 120                 125             


Asp Ile Leu Leu Gln Gly Arg Leu Tyr Leu Ser Glu Asn Trp Ile Cys 
    130                 135                 140                 


Phe Tyr Ser Asn Ile Phe Arg Trp Glu Thr Leu Leu Thr Val Arg Leu 
145                 150                 155                 160 


Lys Asp Ile Cys Ser Met Thr Lys Glu Lys Thr Ala Arg Leu Ile Pro 
                165                 170                 175     


Asn Ala Ile Gln Val Cys Thr Asp Ser Glu Lys His Phe Phe Thr Ser 
            180                 185                 190         


Phe Gly Ala Arg Asp Arg Thr Tyr Met Met Met Phe Arg Leu Trp Gln 
        195                 200                 205             


Asn Ala Leu Leu Glu Lys Pro Leu Cys Pro Lys Glu Leu Trp His Phe 
    210                 215                 220                 


Val His Gln Cys Tyr Gly Asn Glu Leu Gly Leu Thr Ser Asp Asp Glu 
225                 230                 235                 240 


Asp Tyr Val Pro Pro Asp Asp Asp Phe Asn Thr Met Gly Tyr Cys Glu 
                245                 250                 255     


Glu Ile Pro Val Glu Glu Asn Glu Val Asn Asp Ser Ser Ser Lys Ser 
            260                 265                 270         


Ser Ile Glu Thr Lys Pro Asp Ala Ser Pro Gln Leu Pro Lys Lys Ser 
        275                 280                 285             


Ile Thr Asn Ser Thr Leu Thr Ser Thr Gly Ser Ser Glu Ala Pro Val 
    290                 295                 300                 


Ser Phe Asp Gly Leu Pro Leu Glu Glu Glu Ala Leu Glu Gly Asp Gly 
305                 310                 315                 320 


Ser Leu Glu Lys Glu Leu Ala Ile Asp Asn Ile Met Gly Glu Lys Ile 
                325                 330                 335     


Glu Met Ile Ala Pro Val Asn Ser Pro Ser Leu Asp Phe Asn Asp Asn 
            340                 345                 350         


Glu Asp Ile Pro Thr Glu Leu Ser Asp Ser Ser Asp Thr His Asp Glu 
        355                 360                 365             


Gly Glu Val Gln Ala Phe Tyr Glu Asp Leu Ser Gly Arg Gln Tyr Val 
    370                 375                 380                 


Asn Glu Val Phe Asn Phe Ser Val Asp Lys Leu Tyr Asp Leu Leu Phe 
385                 390                 395                 400 


Thr Asn Ser Pro Phe Gln Arg Asp Phe Met Glu Gln Arg Arg Phe Ser 
                405                 410                 415     


Asp Ile Ile Phe His Pro Trp Lys Lys Glu Glu Asn Gly Asn Gln Ser 
            420                 425                 430         


Arg Val Ile Leu Tyr Thr Ile Thr Leu Thr Asn Pro Leu Ala Pro Lys 
        435                 440                 445             


Thr Ala Thr Val Arg Glu Thr Gln Thr Met Tyr Lys Ala Ser Gln Glu 
    450                 455                 460                 


Ser Glu Cys Tyr Val Ile Asp Ala Glu Val Leu Thr His Asp Val Pro 
465                 470                 475                 480 


Tyr His Asp Tyr Phe Tyr Thr Ile Asn Arg Tyr Thr Leu Thr Arg Val 
                485                 490                 495     


Ala Arg Asn Lys Ser Arg Leu Arg Val Ser Thr Glu Leu Arg Tyr Arg 
            500                 505                 510         


Lys Gln Pro Trp Gly Leu Val Lys Thr Phe Ile Glu Lys Asn Phe Trp 
        515                 520                 525             


Ser Gly Leu Glu Asp Tyr Phe Arg His Leu Glu Ser Glu Leu Ala Lys 
    530                 535                 540                 


Thr Glu Ser Thr Tyr Leu Ala Glu Met His Arg Gln Ser Pro Lys Glu 
545                 550                 555                 560 


Lys Ala Ser Lys Thr Thr Thr Val Arg Arg Arg Lys Arg Pro His Ala 
                565                 570                 575     


His Leu Arg Val Pro His Leu Glu Glu Val Met Ser Pro Val Thr Thr 
            580                 585                 590         


Pro Thr Asp Glu Asp Val Gly His Arg Ile Lys His Val Ala Gly Ser 
        595                 600                 605             


Thr Gln Thr Arg His Ile Pro Glu Asp Thr Pro Asn Gly Phe His Leu 
    610                 615                 620                 


Gln Ser Val Ser Lys Leu Leu Leu Val Ile Ser Cys Val Ile Cys Phe 
625                 630                 635                 640 


Ser Leu Val Leu Leu Val Ile Leu Asn Met Met Leu Phe Tyr Lys Leu 
                645                 650                 655     


Trp Met Leu Glu Tyr Thr Thr Gln Thr Leu Thr Ala Trp Gln Gly Leu 
            660                 665                 670         


Arg Leu Gln Glu Arg Leu Pro Gln Ser Gln Thr Glu Trp Ala Gln Leu 
        675                 680                 685             


Leu Glu Ser Gln Gln Lys Tyr His Asp Thr Glu Leu Gln Lys Trp Arg 
    690                 695                 700                 


Glu Ile Ile Lys Ser Ser Val Met Leu Leu Asp Gln Met Lys Asp Ser 
705                 710                 715                 720 


Leu Ile Asn Leu Gln Asn Gly Ile Arg Ser Arg Asp Tyr Thr Ser Glu 
                725                 730                 735     


Ser Glu Glu Lys Arg Asn Arg Tyr His 
            740                 745 


<210>  4699
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAMD3__Homo_sapiens__NP_001139791

<400>  4699

Met Thr Arg Arg Gln Gln Val Leu Gln Ala Lys Arg Ser Ile Gln Gln 
1               5                   10                  15      


Thr Phe Gln Ala Gln Leu Met Pro Trp Lys Ser Met Phe His Gly Arg 
            20                  25                  30          


Glu Val Lys Pro Val Gly Pro Asp Leu Glu Leu Ser Glu Ala Glu Asn 
        35                  40                  45              


Gly Val Glu Glu Lys Lys Lys Ala Cys Arg Ser Pro Thr Ala Gln Ser 
    50                  55                  60                  


Pro Thr Pro Ser Val Glu Ala Asp Ser Pro Asp Gln Lys Lys Ile Ile 
65                  70                  75                  80  


Ser Leu Trp Ser Lys Ser Ser Phe Asp Gly Ala Ser Leu Ala Ser Asp 
                85                  90                  95      


Lys Asn Asp Cys Lys Thr Glu Ser Lys Asn Asp Pro Lys Thr Glu Arg 
            100                 105                 110         


Lys Lys Ser Ser Ser Ser Ser Gln Tyr Lys Ala Asn Met His Phe His 
        115                 120                 125             


Lys Leu Phe Leu Ser Val Pro Thr Glu Glu Pro Leu Lys Gln Ser Phe 
    130                 135                 140                 


Thr Cys Ala Leu Gln Lys Glu Ile Leu Tyr Gln Gly Lys Leu Phe Val 
145                 150                 155                 160 


Ser Glu Asn Trp Ile Cys Phe His Ser Lys Val Phe Gly Lys Asp Thr 
                165                 170                 175     


Lys Ile Ser Ile Pro Ala Phe Ser Val Thr Leu Ile Lys Lys Thr Lys 
            180                 185                 190         


Thr Ala Leu Leu Val Pro Asn Ala Leu Ile Ile Ala Thr Val Thr Asp 
        195                 200                 205             


Arg Tyr Ile Phe Val Ser Leu Leu Ser Arg Asp Ser Thr Tyr Lys Leu 
    210                 215                 220                 


Leu Lys Ser Val Cys Gly His Leu Glu Asn Thr Ser Val Gly Asn Ser 
225                 230                 235                 240 


Pro Asn Pro Ser Ser Ala Glu Asn Ser Phe Arg Ala Asp Arg Pro Ser 
                245                 250                 255     


Ser Leu Pro Leu Asp Phe Asn Asp Glu Phe Ser Asp Leu Asp Gly Val 
            260                 265                 270         


Val Gln Gln Arg Arg Gln Asp Met Glu Gly Tyr Ser Ser Ser Gly Ser 
        275                 280                 285             


Gln Thr Pro Glu Ser Glu Asn Ser Arg Asp Phe His Ala Thr Glu Ser 
    290                 295                 300                 


Gln Thr Val Leu Asn Val Ser Lys Gly Glu Ala Lys Pro Thr Arg Ala 
305                 310                 315                 320 


Asp Ala His Val Asn Arg Val Pro Glu Gly Lys Ala Lys Ser Leu Pro 
                325                 330                 335     


Val Gln Gly Leu Ser Glu Thr Val Gly Ile Leu His Lys Val Lys Ser 
            340                 345                 350         


Gln Lys Cys Pro Met Leu His His Ile Leu Ile Phe Tyr Ala Ile Val 
        355                 360                 365             


Val Cys Ala Leu Ile Ile Ser Thr Phe Tyr Met Arg Tyr Arg Ile Asn 
    370                 375                 380                 


Thr Leu Glu Glu Gln Leu Gly Leu Leu Thr Ser Ile Val Asp Thr His 
385                 390                 395                 400 


Asn Thr Glu Gln Ala Ala Pro Ser Gly Leu Arg Ser Gln Val Gln Phe 
                405                 410                 415     


Asn Val Glu Val Leu Cys Gln Glu Leu Thr Ala Asn Ile Val Lys Leu 
            420                 425                 430         


Glu Lys Ile Gln Asn Asn Leu Gln Lys Leu Leu Glu Asn Gly Asp 
        435                 440                 445         


<210>  4700
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAMD4__Homo_sapiens__NP_055939

<400>  4700

Met Leu Arg Arg Leu Asp Lys Ile Arg Phe Arg Gly His Lys Arg Asp 
1               5                   10                  15      


Asp Phe Leu Asp Leu Ala Glu Ser Pro Asn Ala Ser Asp Thr Glu Cys 
            20                  25                  30          


Ser Asp Glu Ile Pro Leu Lys Val Pro Arg Thr Ser Pro Arg Asp Ser 
        35                  40                  45              


Glu Glu Leu Arg Asp Pro Ala Gly Pro Gly Thr Leu Ile Met Ala Thr 
    50                  55                  60                  


Gly Val Gln Asp Phe Asn Arg Thr Glu Phe Asp Arg Leu Asn Glu Ile 
65                  70                  75                  80  


Lys Gly His Leu Glu Ile Ala Leu Leu Glu Lys His Phe Leu Gln Glu 
                85                  90                  95      


Glu Leu Arg Lys Leu Arg Glu Glu Thr Asn Ala Glu Met Leu Arg Gln 
            100                 105                 110         


Glu Leu Asp Arg Glu Arg Gln Arg Arg Met Glu Leu Glu Gln Lys Val 
        115                 120                 125             


Gln Glu Val Leu Lys Ala Arg Thr Glu Glu Gln Met Ala Gln Gln Pro 
    130                 135                 140                 


Pro Lys Gly Gln Ala Gln Ala Ser Asn Gly Ala Glu Arg Arg Ser Gln 
145                 150                 155                 160 


Gly Leu Ser Ser Arg Leu Gln Lys Trp Phe Tyr Glu Arg Phe Gly Glu 
                165                 170                 175     


Tyr Val Glu Asp Phe Arg Phe Gln Pro Glu Glu Asn Thr Val Glu Thr 
            180                 185                 190         


Glu Glu Pro Leu Ser Ala Arg Arg Leu Thr Glu Asn Met Arg Arg Leu 
        195                 200                 205             


Lys Arg Gly Ala Lys Pro Val Thr Asn Phe Val Lys Asn Leu Ser Ala 
    210                 215                 220                 


Leu Ser Asp Trp Tyr Ser Val Tyr Thr Ser Ala Ile Ala Phe Thr Val 
225                 230                 235                 240 


Tyr Met Asn Ala Val Trp His Gly Trp Ala Ile Pro Leu Phe Leu Phe 
                245                 250                 255     


Leu Ala Ile Leu Arg Leu Ser Leu Asn Tyr Leu Ile Ala Arg Gly Trp 
            260                 265                 270         


Arg Ile Gln Trp Ser Ile Val Pro Glu Val Ser Glu Pro Val Glu Pro 
        275                 280                 285             


Pro Lys Glu Asp Leu Thr Val Ser Glu Lys Phe Gln Leu Val Leu Asp 
    290                 295                 300                 


Val Ala Gln Lys Ala Gln Asn Leu Phe Gly Lys Met Ala Asp Ile Leu 
305                 310                 315                 320 


Glu Lys Ile Lys Asn Leu Phe Met Trp Val Gln Pro Glu Ile Thr Gln 
                325                 330                 335     


Lys Leu Tyr Val Ala Leu Trp Ala Ala Phe Leu Ala Ser Cys Phe Phe 
            340                 345                 350         


Pro Tyr Arg Leu Val Gly Leu Ala Val Gly Leu Tyr Ala Gly Ile Lys 
        355                 360                 365             


Phe Phe Leu Ile Asp Phe Ile Phe Lys Arg Cys Pro Arg Leu Arg Ala 
    370                 375                 380                 


Lys Tyr Asp Thr Pro Tyr Ile Ile Trp Arg Ser Leu Pro Thr Asp Pro 
385                 390                 395                 400 


Gln Leu Lys Glu Arg Ser Ser Ala Ala Val Ser Arg Arg Leu Gln Thr 
                405                 410                 415     


Thr Ser Ser Arg Ser Tyr Val Pro Ser Ala Pro Ala Gly Leu Gly Lys 
            420                 425                 430         


Glu Glu Asp Ala Gly Arg Phe His Ser Thr Lys Lys Gly Asn Phe His 
        435                 440                 445             


Glu Ile Phe Asn Leu Thr Glu Asn Glu Arg Pro Leu Ala Val Cys Glu 
    450                 455                 460                 


Asn Gly Trp Arg Cys Cys Leu Ile Asn Arg Asp Arg Lys Met Pro Thr 
465                 470                 475                 480 


Asp Tyr Ile Arg Asn Gly Val Leu Tyr Val Thr Glu Asn Tyr Leu Cys 
                485                 490                 495     


Phe Glu Ser Ser Lys Ser Gly Ser Ser Lys Arg Asn Lys Val Ile Lys 
            500                 505                 510         


Leu Val Asp Ile Thr Asp Ile Gln Lys Tyr Lys Val Leu Ser Val Leu 
        515                 520                 525             


Pro Gly Ser Gly Met Gly Ile Ala Val Ser Thr Pro Ser Thr Gln Lys 
    530                 535                 540                 


Pro Leu Val Phe Gly Ala Met Val His Arg Asp Glu Ala Phe Glu Thr 
545                 550                 555                 560 


Ile Leu Ser Gln Tyr Ile Lys Ile Thr Ser Ala Ala Ala Ser Gly Gly 
                565                 570                 575     


Asp Ser 
        


<210>  4701
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAP2__Homo_sapiens__NP_001278754

<400>  4701

Met Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Thr 
            180                 185                 190         


Leu Pro Leu Gln Gln His Gln His Gln Pro Gln Pro Pro Gln Tyr Ala 
        195                 200                 205             


Pro Ala Pro Gln Gln Leu Gln Gln Pro Pro Gln Gln Arg Tyr Leu Gln 
    210                 215                 220                 


His His His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp Ile Asn 
225                 230                 235                 240 


Asp Gly His Cys Gly Thr Gly Leu Gly Ser Glu Met Asn Ala Ala Leu 
                245                 250                 255     


Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Ala Ala Gly Arg 
            260                 265                 270         


Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp Asp 
        275                 280                 285             


Glu Leu Gly Phe His Ser Gly Glu Val Val Glu Val Leu Asp Ser Ser 
    290                 295                 300                 


Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu Phe 
305                 310                 315                 320 


Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
                325                 330 


<210>  4702
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAP__Homo_sapiens__NP_006604

<400>  4702

Met Glu Ser Val Ala Leu Tyr Ser Phe Gln Ala Thr Glu Ser Asp Glu 
1               5                   10                  15      


Leu Ala Phe Asn Lys Gly Asp Thr Leu Lys Ile Leu Asn Met Glu Asp 
            20                  25                  30          


Asp Gln Asn Trp Tyr Lys Ala Glu Leu Arg Gly Val Glu Gly Phe Ile 
        35                  40                  45              


Pro Lys Asn Tyr Ile Arg Val Lys Pro His Pro Trp Tyr Ser Gly Arg 
    50                  55                  60                  


Ile Ser Arg Gln Leu Ala Glu Glu Ile Leu Met Lys Arg Asn His Leu 
65                  70                  75                  80  


Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ser Pro Gly Glu Phe Ser 
                85                  90                  95      


Val Ser Val Asn Tyr Gly Asp Gln Val Gln His Phe Lys Val Leu Arg 
            100                 105                 110         


Glu Ala Ser Gly Lys Tyr Phe Leu Trp Glu Glu Lys Phe Asn Ser Leu 
        115                 120                 125             


Asn Glu Leu Val Asp Phe Tyr Arg Thr Thr Thr Ile Ala Lys Lys Arg 
    130                 135                 140                 


Gln Ile Phe Leu Arg Asp Glu Glu Pro Leu Leu Lys Ser Pro Gly Ala 
145                 150                 155                 160 


Cys Phe Ala Gln Ala Gln Phe Asp Phe Ser Ala Gln Asp Pro Ser Gln 
                165                 170                 175     


Leu Ser Phe Arg Arg Gly Asp Ile Ile Glu Val Leu Glu Arg Pro Asp 
            180                 185                 190         


Pro His Trp Trp Arg Gly Arg Ser Cys Gly Arg Val Gly Phe Phe Pro 
        195                 200                 205             


Arg Ser Tyr Val Gln Pro Val His Leu 
    210                 215         


<210>  4703
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRASP__Homo_sapiens__NP_001258785

<400>  4703

Met Thr Leu Leu Pro Ser Lys Gly Gly Asp Thr Ile Ala Ser Val Asn 
1               5                   10                  15      


Gly Leu Asn Val Glu Gly Ile Arg His Arg Glu Ile Val Asp Ile Ile 
            20                  25                  30          


Lys Ala Ser Gly Asn Val Leu Arg Leu Glu Thr Leu Tyr Gly Thr Ser 
        35                  40                  45              


Ile Arg Lys Ala Glu Leu Glu Ala Arg Leu Gln Tyr Leu Lys Gln Thr 
    50                  55                  60                  


Leu Tyr Glu Lys Trp Gly Glu Tyr Arg Ser Leu Met Val Gln Glu Gln 
65                  70                  75                  80  


Arg Leu Val His Gly Leu Val Val Lys Asp Pro Ser Ile Tyr Asp Thr 
                85                  90                  95      


Leu Glu Ser Val Arg Ser Cys Leu Tyr Gly Ala Gly Leu Leu Pro Gly 
            100                 105                 110         


Ser Leu Pro Phe Gly Pro Leu Leu Ala Val Pro Gly Arg Pro Arg Gly 
        115                 120                 125             


Gly Ala Arg Arg Ala Arg Gly Asp Ala Asp Asp Ala Val Tyr His Thr 
    130                 135                 140                 


Cys Phe Phe Gly Asp Ser Glu Pro Pro Ala Leu Pro Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Ala Arg Ala Phe Gly Pro Gly Pro Ala Glu Thr Pro Ala Val Gly 
                165                 170                 175     


Pro Gly Pro Gly Pro Arg Ala Ala Leu Ser Arg Ser Ala Ser Val Arg 
            180                 185                 190         


Cys Ala Gly Pro Gly Gly Gly Gly Gly Gly Gly Ala Pro Gly Ala Leu 
        195                 200                 205             


Trp Thr Glu Ala Arg Glu Gln Ala Leu Cys Gly Pro Gly Leu Arg Lys 
    210                 215                 220                 


Thr Lys Tyr Arg Ser Phe Arg Arg Arg Leu Leu Lys Phe Ile Pro Gly 
225                 230                 235                 240 


Leu Asn Arg Ser Leu Glu Glu Glu Glu Ser Gln Leu 
                245                 250         


<210>  4704
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRB10__Homo_sapiens__NP_001001549

<400>  4704

Met Ala Leu Ala Gly Cys Pro Asp Ser Phe Leu His His Pro Tyr Tyr 
1               5                   10                  15      


Gln Asp Lys Val Glu Gln Thr Pro Arg Ser Gln Gln Asp Pro Ala Gly 
            20                  25                  30          


Pro Gly Leu Pro Ala Gln Ser Asp Arg Leu Ala Asn His Gln Glu Asp 
        35                  40                  45              


Asp Val Asp Leu Glu Ala Leu Val Asn Asp Met Asn Ala Ser Leu Glu 
    50                  55                  60                  


Ser Leu Tyr Ser Ala Cys Ser Met Gln Ser Asp Thr Val Pro Leu Leu 
65                  70                  75                  80  


Gln Asn Gly Gln His Ala Arg Ser Gln Pro Arg Ala Ser Gly Pro Pro 
                85                  90                  95      


Arg Ser Ile Gln Pro Gln Val Ser Pro Arg Gln Arg Val Gln Arg Ser 
            100                 105                 110         


Gln Pro Val His Ile Leu Ala Val Arg Arg Leu Gln Glu Glu Asp Gln 
        115                 120                 125             


Gln Phe Arg Thr Ser Ser Leu Pro Ala Ile Pro Asn Pro Phe Pro Glu 
    130                 135                 140                 


Leu Cys Gly Pro Gly Ser Pro Pro Val Leu Thr Pro Gly Ser Leu Pro 
145                 150                 155                 160 


Pro Ser Gln Ala Ala Ala Lys Gln Asp Val Lys Val Phe Ser Glu Asp 
                165                 170                 175     


Gly Thr Ser Lys Val Val Glu Ile Leu Ala Asp Met Thr Ala Arg Asp 
            180                 185                 190         


Leu Cys Gln Leu Leu Val Tyr Lys Ser His Cys Val Asp Asp Asn Ser 
        195                 200                 205             


Trp Thr Leu Val Glu His His Pro His Leu Gly Leu Glu Arg Cys Leu 
    210                 215                 220                 


Glu Asp His Glu Leu Val Val Gln Val Glu Ser Thr Met Ala Ser Glu 
225                 230                 235                 240 


Ser Lys Phe Leu Phe Arg Lys Asn Tyr Ala Lys Tyr Glu Phe Phe Lys 
                245                 250                 255     


Asn Pro Met Asn Phe Phe Pro Glu Gln Met Val Thr Trp Cys Gln Gln 
            260                 265                 270         


Ser Asn Gly Ser Gln Thr Gln Leu Leu Gln Glu Pro Arg His Leu Gln 
        275                 280                 285             


Leu Leu Ala Asp Leu Glu Asp Ser Asn Ile Phe Ser Leu Ile Ala Gly 
    290                 295                 300                 


Arg Lys Gln Tyr Asn Ala Pro Thr Asp His Gly Leu Cys Ile Lys Pro 
305                 310                 315                 320 


Asn Lys Val Arg Asn Glu Thr Lys Glu Leu Arg Leu Leu Cys Ala Glu 
                325                 330                 335     


Asp Glu Gln Thr Arg Thr Cys Trp Met Thr Ala Phe Arg Leu Leu Lys 
            340                 345                 350         


Tyr Gly Met Leu Leu Tyr Gln Asn Tyr Arg Ile Pro Gln Gln Arg Lys 
        355                 360                 365             


Ala Leu Leu Ser Pro Phe Ser Thr Pro Val Arg Ser Val Ser Glu Asn 
    370                 375                 380                 


Ser Leu Val Ala Met Asp Phe Ser Gly Gln Thr Gly Arg Val Ile Glu 
385                 390                 395                 400 


Asn Pro Ala Glu Ala Gln Ser Ala Ala Leu Glu Glu Gly His Ala Trp 
                405                 410                 415     


Arg Lys Arg Ser Thr Arg Met Asn Ile Leu Gly Ser Gln Ser Pro Leu 
            420                 425                 430         


His Pro Ser Thr Leu Ser Thr Val Ile His Arg Thr Gln His Trp Phe 
        435                 440                 445             


His Gly Arg Ile Ser Arg Glu Glu Ser His Arg Ile Ile Lys Gln Gln 
    450                 455                 460                 


Gly Leu Val Asp Gly Leu Phe Leu Leu Arg Asp Ser Gln Ser Asn Pro 
465                 470                 475                 480 


Lys Ala Phe Val Leu Thr Leu Cys His His Gln Lys Ile Lys Asn Phe 
                485                 490                 495     


Gln Ile Leu Pro Cys Glu Asp Asp Gly Gln Thr Phe Phe Ser Leu Asp 
            500                 505                 510         


Asp Gly Asn Thr Lys Phe Ser Asp Leu Ile Gln Leu Val Asp Phe Tyr 
        515                 520                 525             


Gln Leu Asn Lys Gly Val Leu Pro Cys Lys Leu Lys His His Cys Ile 
    530                 535                 540                 


Arg Val Ala Leu 
545             


<210>  4705
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRB14__Homo_sapiens__NP_001290351

<400>  4705

Met Ser Leu Ser Ala Arg Arg Val Thr Leu Pro Ala Ile Thr Pro Ile 
1               5                   10                  15      


Ile Leu Gln Lys Arg Val Ile Lys Val Tyr Ser Glu Asp Glu Thr Ser 
            20                  25                  30          


Arg Ala Leu Asp Val Pro Ser Asp Ile Thr Ala Arg Asp Val Cys Gln 
        35                  40                  45              


Leu Leu Ile Leu Lys Asn His Tyr Ile Asp Asp His Ser Trp Thr Leu 
    50                  55                  60                  


Phe Glu His Leu Pro His Ile Gly Val Glu Arg Thr Ile Glu Asp His 
65                  70                  75                  80  


Glu Leu Val Ile Glu Val Leu Ser Asn Trp Gly Ile Glu Glu Glu Asn 
                85                  90                  95      


Lys Leu Tyr Phe Arg Lys Asn Tyr Ala Lys Tyr Glu Phe Phe Lys Asn 
            100                 105                 110         


Pro Met Tyr Phe Phe Pro Glu His Met Val Ser Phe Ala Thr Glu Thr 
        115                 120                 125             


Asn Gly Glu Ile Ser Pro Thr Gln Ile Leu Gln Met Phe Leu Ser Ser 
    130                 135                 140                 


Ser Thr Tyr Pro Glu Ile His Gly Phe Leu His Ala Lys Glu Gln Gly 
145                 150                 155                 160 


Lys Lys Ser Trp Lys Lys Ile Tyr Phe Phe Leu Arg Arg Ser Gly Leu 
                165                 170                 175     


Tyr Phe Ser Thr Lys Gly Thr Ser Lys Glu Pro Arg His Leu Gln Phe 
            180                 185                 190         


Phe Ser Glu Phe Gly Asn Ser Asp Ile Tyr Val Ser Leu Ala Gly Lys 
        195                 200                 205             


Lys Lys His Gly Ala Pro Thr Asn Tyr Gly Phe Cys Phe Lys Pro Asn 
    210                 215                 220                 


Lys Ala Gly Gly Pro Arg Asp Leu Lys Met Leu Cys Ala Glu Glu Glu 
225                 230                 235                 240 


Gln Ser Arg Thr Cys Trp Val Thr Ala Ile Arg Leu Leu Lys Tyr Gly 
                245                 250                 255     


Met Gln Leu Tyr Gln Asn Tyr Met His Pro Tyr Gln Gly Arg Ser Gly 
            260                 265                 270         


Cys Ser Ser Gln Ser Ile Ser Pro Met Arg Ser Ile Ser Glu Asn Ser 
        275                 280                 285             


Leu Val Ala Met Asp Phe Ser Gly Gln Lys Ser Arg Val Ile Glu Asn 
    290                 295                 300                 


Pro Thr Glu Ala Leu Ser Val Ala Val Glu Glu Gly Leu Ala Trp Arg 
305                 310                 315                 320 


Lys Lys Gly Cys Leu Arg Leu Gly Thr His Gly Ser Pro Thr Ala Ser 
                325                 330                 335     


Ser Gln Ser Ser Ala Thr Asn Met Ala Ile His Arg Ser Gln Pro Trp 
            340                 345                 350         


Phe His His Lys Ile Ser Arg Asp Glu Ala Gln Arg Leu Ile Ile Gln 
        355                 360                 365             


Gln Gly Leu Val Asp Gly Val Phe Leu Val Arg Asp Ser Gln Ser Asn 
    370                 375                 380                 


Pro Lys Thr Phe Val Leu Ser Met Ser His Gly Gln Lys Ile Lys His 
385                 390                 395                 400 


Phe Gln Ile Ile Pro Val Glu Asp Asp Gly Glu Met Phe His Thr Leu 
                405                 410                 415     


Asp Asp Gly His Thr Arg Phe Thr Asp Leu Ile Gln Leu Val Glu Phe 
            420                 425                 430         


Tyr Gln Leu Asn Lys Gly Val Leu Pro Cys Lys Leu Lys His Tyr Cys 
        435                 440                 445             


Ala Arg Ile Ala Leu 
    450             


<210>  4706
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRB2__Homo_sapiens__NP_002077

<400>  4706

Met Glu Ala Ile Ala Lys Tyr Asp Phe Lys Ala Thr Ala Asp Asp Glu 
1               5                   10                  15      


Leu Ser Phe Lys Arg Gly Asp Ile Leu Lys Val Leu Asn Glu Glu Cys 
            20                  25                  30          


Asp Gln Asn Trp Tyr Lys Ala Glu Leu Asn Gly Lys Asp Gly Phe Ile 
        35                  40                  45              


Pro Lys Asn Tyr Ile Glu Met Lys Pro His Pro Trp Phe Phe Gly Lys 
    50                  55                  60                  


Ile Pro Arg Ala Lys Ala Glu Glu Met Leu Ser Lys Gln Arg His Asp 
65                  70                  75                  80  


Gly Ala Phe Leu Ile Arg Glu Ser Glu Ser Ala Pro Gly Asp Phe Ser 
                85                  90                  95      


Leu Ser Val Lys Phe Gly Asn Asp Val Gln His Phe Lys Val Leu Arg 
            100                 105                 110         


Asp Gly Ala Gly Lys Tyr Phe Leu Trp Val Val Lys Phe Asn Ser Leu 
        115                 120                 125             


Asn Glu Leu Val Asp Tyr His Arg Ser Thr Ser Val Ser Arg Asn Gln 
    130                 135                 140                 


Gln Ile Phe Leu Arg Asp Ile Glu Gln Val Pro Gln Gln Pro Thr Tyr 
145                 150                 155                 160 


Val Gln Ala Leu Phe Asp Phe Asp Pro Gln Glu Asp Gly Glu Leu Gly 
                165                 170                 175     


Phe Arg Arg Gly Asp Phe Ile His Val Met Asp Asn Ser Asp Pro Asn 
            180                 185                 190         


Trp Trp Lys Gly Ala Cys His Gly Gln Thr Gly Met Phe Pro Arg Asn 
        195                 200                 205             


Tyr Val Thr Pro Val Asn Arg Asn Val 
    210                 215         


<210>  4707
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRB7__Homo_sapiens__NP_001229371

<400>  4707

Met Gly Lys Trp Arg Pro Gly Gln Gly His Thr Thr Gly Ser Val Lys 
1               5                   10                  15      


Pro Leu Ser Arg Ser Asp Ala Met Glu Leu Asp Leu Ser Pro Pro His 
            20                  25                  30          


Leu Ser Ser Ser Pro Glu Asp Leu Cys Pro Ala Pro Gly Thr Pro Pro 
        35                  40                  45              


Gly Thr Pro Arg Pro Pro Asp Thr Pro Leu Pro Glu Glu Val Lys Arg 
    50                  55                  60                  


Ser Gln Pro Leu Leu Ile Pro Thr Thr Gly Arg Lys Leu Arg Glu Glu 
65                  70                  75                  80  


Glu Arg Arg Ala Thr Ser Leu Pro Ser Ile Pro Asn Pro Phe Pro Glu 
                85                  90                  95      


Leu Cys Ser Pro Pro Ser Gln Ser Pro Ile Leu Gly Gly Pro Ser Ser 
            100                 105                 110         


Ala Arg Gly Leu Leu Pro Arg Asp Ala Ser Arg Pro His Val Val Lys 
        115                 120                 125             


Val Tyr Ser Glu Asp Gly Ala Cys Arg Ser Val Glu Val Ala Ala Gly 
    130                 135                 140                 


Ala Thr Ala Arg His Val Cys Glu Met Leu Val Gln Arg Ala His Ala 
145                 150                 155                 160 


Leu Ser Asp Glu Thr Trp Gly Leu Val Glu Cys His Pro His Leu Ala 
                165                 170                 175     


Leu Glu Arg Gly Leu Glu Asp His Glu Ser Val Val Glu Val Gln Ala 
            180                 185                 190         


Ala Trp Pro Val Gly Gly Asp Ser Arg Phe Val Phe Arg Lys Asn Phe 
        195                 200                 205             


Ala Lys Tyr Glu Leu Phe Lys Ser Ser Pro His Ser Leu Phe Pro Glu 
    210                 215                 220                 


Lys Met Val Ser Ser Cys Leu Asp Ala His Thr Gly Ile Ser His Glu 
225                 230                 235                 240 


Asp Leu Ile Gln Asn Phe Leu Asn Ala Gly Ser Phe Pro Glu Ile Gln 
                245                 250                 255     


Gly Phe Leu Gln Leu Arg Gly Ser Gly Arg Lys Leu Trp Lys Arg Phe 
            260                 265                 270         


Phe Cys Phe Leu Arg Arg Ser Gly Leu Tyr Tyr Ser Thr Lys Gly Thr 
        275                 280                 285             


Ser Lys Asp Pro Arg His Leu Gln Tyr Val Ala Asp Val Asn Glu Ser 
    290                 295                 300                 


Asn Val Tyr Val Val Thr Gln Gly Arg Lys Leu Tyr Gly Met Pro Thr 
305                 310                 315                 320 


Asp Phe Gly Phe Cys Val Lys Pro Asn Lys Leu Arg Asn Gly His Lys 
                325                 330                 335     


Gly Leu Arg Ile Phe Cys Ser Glu Asp Glu Gln Ser Arg Thr Cys Trp 
            340                 345                 350         


Leu Ala Ala Phe Arg Leu Phe Lys Tyr Gly Val Gln Leu Tyr Lys Asn 
        355                 360                 365             


Tyr Gln Gln Ala Gln Ser Arg His Leu His Pro Ser Cys Leu Gly Ser 
    370                 375                 380                 


Pro Pro Leu Arg Ser Ala Ser Asp Asn Thr Leu Val Ala Met Asp Phe 
385                 390                 395                 400 


Ser Gly His Ala Gly Arg Val Ile Glu Asn Pro Arg Glu Ala Leu Ser 
                405                 410                 415     


Val Ala Leu Glu Glu Ala Gln Ala Trp Arg Lys Lys Thr Asn His Arg 
            420                 425                 430         


Leu Ser Leu Pro Met Pro Ala Ser Gly Thr Ser Leu Ser Ala Ala Ile 
        435                 440                 445             


His Arg Thr Gln Leu Trp Phe His Gly Arg Ile Ser Arg Glu Glu Ser 
    450                 455                 460                 


Gln Arg Leu Ile Gly Gln Gln Gly Leu Val Asp Gly Leu Phe Leu Val 
465                 470                 475                 480 


Arg Glu Ser Gln Arg Asn Pro Gln Gly Phe Val Leu Ser Leu Cys His 
                485                 490                 495     


Leu Gln Lys Val Lys His Tyr Leu Ile Leu Pro Ser Glu Glu Glu Gly 
            500                 505                 510         


Arg Leu Tyr Phe Ser Met Asp Asp Gly Gln Thr Arg Phe Thr Asp Leu 
        515                 520                 525             


Leu Gln Leu Val Glu Phe His Gln Leu Asn Arg Gly Ile Leu Pro Cys 
    530                 535                 540                 


Leu Leu Arg His Cys Cys Thr Arg Val Ala Leu 
545                 550                 555 


<210>  4708
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GREB1__Homo_sapiens__NP_683701

<400>  4708

Met Gly Asn Ser Tyr Ala Gly Gln Leu Lys Thr Thr Arg Phe Glu Glu 
1               5                   10                  15      


Val Leu His Asn Ser Ile Glu Ala Ser Leu Arg Ser Asn Asn Leu Val 
            20                  25                  30          


Pro Arg Pro Ile Phe Ser Gln Leu Tyr Leu Glu Ala Glu Gln Gln Leu 
        35                  40                  45              


Ala Ala Leu Glu Gly Gly Ser Arg Val Asp Asn Glu Glu Glu Glu Glu 
    50                  55                  60                  


Glu Gly Glu Gly Gly Leu Glu Thr Asn Gly Pro Pro Asn Pro Phe Gln 
65                  70                  75                  80  


Leu His Pro Leu Pro Glu Gly Cys Cys Thr Thr Asp Gly Phe Cys Gln 
                85                  90                  95      


Ala Gly Lys Asp Leu Arg Leu Val Ser Ile Ser Asn Glu Pro Met Asp 
            100                 105                 110         


Val Pro Ala Gly Phe Leu Leu Val Gly Val Lys Ser Pro Ser Leu Pro 
        115                 120                 125             


Asp His Leu Leu Val Cys Ala Val Asp Lys Arg Phe Leu Pro Asp Asp 
    130                 135                 140                 


Asn Gly His Asn Ala Leu Leu Gly Phe Ser Gly Asn Cys Val Gly Cys 
145                 150                 155                 160 


Gly Lys Lys Gly Phe Cys Tyr Phe Thr Glu Phe Ser Asn His Ile Asn 
                165                 170                 175     


Leu Lys Leu Thr Thr Gln Pro Lys Lys Gln Lys His Leu Lys Tyr Tyr 
            180                 185                 190         


Leu Val Arg Asn Ala Gln Gly Thr Leu Thr Lys Gly Pro Leu Ile Cys 
        195                 200                 205             


Trp Lys Gly Ser Glu Phe Arg Ser Arg Gln Ile Pro Ala Ser Thr Cys 
    210                 215                 220                 


Ser Ser Ser Leu Phe Pro Ala Leu Glu Ser Thr Ala Ala Phe Pro Ser 
225                 230                 235                 240 


Glu Pro Val Pro Gly Thr Asn Pro Ser Ile Leu Met Gly Ala Gln Gln 
                245                 250                 255     


Ala Gly Pro Ala Ser Asp His Pro Ser Leu Asn Ala Ala Met Gly Pro 
            260                 265                 270         


Ala Val Phe Asn Gly Lys Asp Ser Pro Lys Cys Gln Gln Leu Ala Lys 
        275                 280                 285             


Asn Asn Leu Leu Ala Leu Pro Arg Pro Ser Ala Leu Gly Ile Leu Ser 
    290                 295                 300                 


Asn Ser Gly Pro Pro Lys Lys Arg His Lys Gly Trp Ser Pro Glu Ser 
305                 310                 315                 320 


Pro Ser Ala Pro Asp Gly Gly Cys Pro Gln Gly Gly Gly Asn Arg Ala 
                325                 330                 335     


Lys Tyr Glu Ser Ala Gly Met Ser Cys Val Pro Gln Val Gly Leu Val 
            340                 345                 350         


Gly Pro Ala Ser Val Thr Phe Pro Val Val Ala Ser Gly Glu Pro Val 
        355                 360                 365             


Ser Val Pro Asp Asn Leu Leu Lys Ile Cys Lys Ala Lys Pro Val Ile 
    370                 375                 380                 


Phe Lys Val Phe Val Asn Gly Ala Thr Gln Met Val Ala Leu Gly Pro 
385                 390                 395                 400 


Ala Glu Pro Ala Ser Pro Arg Ser Leu 
                405                 


<210>  4709
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GREM1__Homo_sapiens__NP_001178252

<400>  4709

Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          


Ile Pro Pro Pro Asp Lys Ala Leu His Val Thr Glu Arg Lys Tyr Leu 
        35                  40                  45              


Lys Arg Asp Trp Cys Lys Thr Gln Pro Leu Lys Gln Thr Ile His Glu 
    50                  55                  60                  


Glu Gly Cys Asn Ser Arg Thr Ile Ile Asn Arg Phe Cys Tyr Gly Gln 
65                  70                  75                  80  


Cys Asn Ser Phe Tyr Ile Pro Arg His Ile Arg Lys Glu Glu Gly Ser 
                85                  90                  95      


Phe Gln Ser Cys Ser Phe Cys Lys Pro Lys Lys Phe Thr Thr Met Met 
            100                 105                 110         


Val Thr Leu Asn Cys Pro Glu Leu Gln Pro Pro Thr Lys Lys Lys Arg 
        115                 120                 125             


Val Thr Arg Val Lys Gln Cys Arg Cys Ile Ser Ile Asp Leu Asp 
    130                 135                 140             


<210>  4710
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GREM2__Homo_sapiens__XP_005273283

<400>  4710

Met Arg Ala Leu Arg Ala Glu Ser Thr Ser Gly Ser Arg Gln Thr Pro 
1               5                   10                  15      


Cys Arg Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val 
            20                  25                  30          


Leu Val Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile 
        35                  40                  45              


Pro Ser Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln 
    50                  55                  60                  


His Gln Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val 
65                  70                  75                  80  


Thr Glu Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu 
                85                  90                  95      


Arg Gln Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn 
            100                 105                 110         


Arg Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val 
        115                 120                 125             


Lys Lys Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln 
    130                 135                 140                 


Arg Val Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro 
145                 150                 155                 160 


Pro Phe Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met 
                165                 170                 175     


Ser Val Asn Leu Ser Asp Ser Asp Lys Gln 
            180                 185     


<210>  4711
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRHL1__Homo_sapiens__NP_937825

<400>  4711

Met Thr Gln Glu Tyr Asp Asn Lys Arg Pro Val Leu Val Leu Gln Asn 
1               5                   10                  15      


Glu Ala Leu Tyr Pro Gln Arg Arg Ser Tyr Thr Ser Glu Asp Glu Ala 
            20                  25                  30          


Trp Lys Ser Phe Leu Glu Asn Pro Leu Thr Ala Ala Thr Lys Ala Met 
        35                  40                  45              


Met Ser Ile Asn Gly Asp Glu Asp Ser Ala Ala Ala Leu Gly Leu Leu 
    50                  55                  60                  


Tyr Asp Tyr Tyr Lys Val Pro Arg Glu Arg Arg Ser Ser Thr Ala Lys 
65                  70                  75                  80  


Pro Glu Val Glu His Pro Glu Pro Asp His Ser Lys Arg Asn Ser Ile 
                85                  90                  95      


Pro Ile Val Thr Glu Gln Pro Leu Ile Ser Ala Gly Glu Asn Arg Val 
            100                 105                 110         


Gln Val Leu Lys Asn Val Pro Phe Asn Ile Val Leu Pro His Gly Asn 
        115                 120                 125             


Gln Leu Gly Ile Asp Lys Arg Gly His Leu Thr Ala Pro Asp Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ile Ala Thr Met Pro Thr His Ser Ile Lys Thr Glu 
145                 150                 155                 160 


Thr Gln Pro His Gly Phe Ala Val Gly Ile Pro Pro Ala Val Tyr His 
                165                 170                 175     


Pro Glu Pro Thr Glu Arg Val Val Val Phe Asp Arg Asn Leu Asn Thr 
            180                 185                 190         


Asp Gln Phe Ser Ser Gly Ala Gln Ala Pro Asn Ala Gln Arg Arg Thr 
        195                 200                 205             


Pro Asp Ser Thr Phe Ser Glu Thr Phe Lys Glu Gly Val Gln Glu Val 
    210                 215                 220                 


Phe Phe Pro Ser Asp Leu Ser Leu Arg Met Pro Gly Met Asn Ser Glu 
225                 230                 235                 240 


Asp Tyr Val Phe Asp Ser Val Ser Gly Asn Asn Phe Glu Tyr Thr Leu 
                245                 250                 255     


Glu Ala Ser Lys Ser Leu Arg Gln Lys Pro Gly Asp Ser Thr Met Thr 
            260                 265                 270         


Tyr Leu Asn Lys Gly Gln Phe Tyr Pro Ile Thr Leu Lys Glu Val Ser 
        275                 280                 285             


Ser Ser Glu Gly Ile His His Pro Ile Ser Lys Val Arg Ser Val Ile 
    290                 295                 300                 


Met Val Val Phe Ala Glu Asp Lys Ser Arg Glu Asp Gln Leu Arg His 
305                 310                 315                 320 


Trp Lys Tyr Trp His Ser Arg Gln His Thr Ala Lys Gln Arg Cys Ile 
                325                 330                 335     


Asp Ile Ala Asp Tyr Lys Glu Ser Phe Asn Thr Ile Ser Asn Ile Glu 
            340                 345                 350         


Glu Ile Ala Tyr Asn Ala Ile Ser Phe Thr Trp Asp Ile Asn Asp Glu 
        355                 360                 365             


Ala Lys Val Phe Ile Ser Val Asn Cys Leu Ser Thr Asp Phe Ser Ser 
    370                 375                 380                 


Gln Lys Gly Val Lys Gly Leu Pro Leu Asn Ile Gln Val Asp Thr Tyr 
385                 390                 395                 400 


Ser Tyr Asn Asn Arg Ser Asn Lys Pro Val His Arg Ala Tyr Cys Gln 
                405                 410                 415     


Ile Lys Val Phe Cys Asp Lys Gly Ala Glu Arg Lys Ile Arg Asp Glu 
            420                 425                 430         


Glu Arg Lys Gln Ser Lys Arg Lys Val Ser Asp Val Lys Val Pro Leu 
        435                 440                 445             


Leu Pro Ser His Lys Arg Met Asp Ile Thr Val Phe Lys Pro Phe Ile 
    450                 455                 460                 


Asp Leu Asp Thr Gln Pro Val Leu Phe Ile Pro Asp Val His Phe Ala 
465                 470                 475                 480 


Asn Leu Gln Arg Gly Thr His Val Leu Pro Ile Ala Ser Glu Glu Leu 
                485                 490                 495     


Glu Gly Glu Gly Ser Val Leu Lys Arg Gly Pro Tyr Gly Thr Glu Asp 
            500                 505                 510         


Asp Phe Ala Val Pro Pro Ser Thr Lys Leu Ala Arg Ile Glu Glu Pro 
        515                 520                 525             


Lys Arg Val Leu Leu Tyr Val Arg Lys Glu Ser Glu Glu Val Phe Asp 
    530                 535                 540                 


Ala Leu Met Leu Lys Thr Pro Ser Leu Lys Gly Leu Met Glu Ala Ile 
545                 550                 555                 560 


Ser Asp Lys Tyr Asp Val Pro His Asp Lys Ile Gly Lys Ile Phe Lys 
                565                 570                 575     


Lys Cys Lys Lys Gly Ile Leu Val Asn Met Asp Asp Asn Ile Val Lys 
            580                 585                 590         


His Tyr Ser Asn Glu Asp Thr Phe Gln Leu Gln Ile Glu Glu Ala Gly 
        595                 600                 605             


Gly Ser Tyr Lys Leu Thr Leu Thr Glu Ile 
    610                 615             


<210>  4712
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRHL2__Homo_sapiens__NP_079191

<400>  4712

Met Ser Gln Glu Ser Asp Asn Asn Lys Arg Leu Val Ala Leu Val Pro 
1               5                   10                  15      


Met Pro Ser Asp Pro Pro Phe Asn Thr Arg Arg Ala Tyr Thr Ser Glu 
            20                  25                  30          


Asp Glu Ala Trp Lys Ser Tyr Leu Glu Asn Pro Leu Thr Ala Ala Thr 
        35                  40                  45              


Lys Ala Met Met Ser Ile Asn Gly Asp Glu Asp Ser Ala Ala Ala Leu 
    50                  55                  60                  


Gly Leu Leu Tyr Asp Tyr Tyr Lys Val Pro Arg Asp Lys Arg Leu Leu 
65                  70                  75                  80  


Ser Val Ser Lys Ala Ser Asp Ser Gln Glu Asp Gln Glu Lys Arg Asn 
                85                  90                  95      


Cys Leu Gly Thr Ser Glu Ala Gln Ser Asn Leu Ser Gly Gly Glu Asn 
            100                 105                 110         


Arg Val Gln Val Leu Lys Thr Val Pro Val Asn Leu Ser Leu Asn Gln 
        115                 120                 125             


Asp His Leu Glu Asn Ser Lys Arg Glu Gln Tyr Ser Ile Ser Phe Pro 
    130                 135                 140                 


Glu Ser Ser Ala Ile Ile Pro Val Ser Gly Ile Thr Val Val Lys Ala 
145                 150                 155                 160 


Glu Asp Phe Thr Pro Val Phe Met Ala Pro Pro Val His Tyr Pro Arg 
                165                 170                 175     


Gly Asp Gly Glu Glu Gln Arg Val Val Ile Phe Glu Gln Thr Gln Tyr 
            180                 185                 190         


Asp Val Pro Ser Leu Ala Thr His Ser Ala Tyr Leu Lys Asp Asp Gln 
        195                 200                 205             


Arg Ser Thr Pro Asp Ser Thr Tyr Ser Glu Ser Phe Lys Asp Ala Ala 
    210                 215                 220                 


Thr Glu Lys Phe Arg Ser Ala Ser Val Gly Ala Glu Glu Tyr Met Tyr 
225                 230                 235                 240 


Asp Gln Thr Ser Ser Gly Thr Phe Gln Tyr Thr Leu Glu Ala Thr Lys 
                245                 250                 255     


Ser Leu Arg Gln Lys Gln Gly Glu Gly Pro Met Thr Tyr Leu Asn Lys 
            260                 265                 270         


Gly Gln Phe Tyr Ala Ile Thr Leu Ser Glu Thr Gly Asp Asn Lys Cys 
        275                 280                 285             


Phe Arg His Pro Ile Ser Lys Val Arg Ser Val Val Met Val Val Phe 
    290                 295                 300                 


Ser Glu Asp Lys Asn Arg Asp Glu Gln Leu Lys Tyr Trp Lys Tyr Trp 
305                 310                 315                 320 


His Ser Arg Gln His Thr Ala Lys Gln Arg Val Leu Asp Ile Ala Asp 
                325                 330                 335     


Tyr Lys Glu Ser Phe Asn Thr Ile Gly Asn Ile Glu Glu Ile Ala Tyr 
            340                 345                 350         


Asn Ala Val Ser Phe Thr Trp Asp Val Asn Glu Glu Ala Lys Ile Phe 
        355                 360                 365             


Ile Thr Val Asn Cys Leu Ser Thr Asp Phe Ser Ser Gln Lys Gly Val 
    370                 375                 380                 


Lys Gly Leu Pro Leu Met Ile Gln Ile Asp Thr Tyr Ser Tyr Asn Asn 
385                 390                 395                 400 


Arg Ser Asn Lys Pro Ile His Arg Ala Tyr Cys Gln Ile Lys Val Phe 
                405                 410                 415     


Cys Asp Lys Gly Ala Glu Arg Lys Ile Arg Asp Glu Glu Arg Lys Gln 
            420                 425                 430         


Asn Arg Lys Lys Gly Lys Gly Gln Ala Ser Gln Thr Gln Cys Asn Ser 
        435                 440                 445             


Ser Ser Asp Gly Lys Leu Ala Ala Ile Pro Leu Gln Lys Lys Ser Asp 
    450                 455                 460                 


Ile Thr Tyr Phe Lys Thr Met Pro Asp Leu His Ser Gln Pro Val Leu 
465                 470                 475                 480 


Phe Ile Pro Asp Val His Phe Ala Asn Leu Gln Arg Thr Gly Gln Val 
                485                 490                 495     


Tyr Tyr Asn Thr Asp Asp Glu Arg Glu Gly Gly Ser Val Leu Val Lys 
            500                 505                 510         


Arg Met Phe Arg Pro Met Glu Glu Glu Phe Gly Pro Val Pro Ser Lys 
        515                 520                 525             


Gln Met Lys Glu Glu Gly Thr Lys Arg Val Leu Leu Tyr Val Arg Lys 
    530                 535                 540                 


Glu Thr Asp Asp Val Phe Asp Ala Leu Met Leu Lys Ser Pro Thr Val 
545                 550                 555                 560 


Lys Gly Leu Met Glu Ala Ile Ser Glu Lys Tyr Gly Leu Pro Val Glu 
                565                 570                 575     


Lys Ile Ala Lys Leu Tyr Lys Lys Ser Lys Lys Gly Ile Leu Val Asn 
            580                 585                 590         


Met Asp Asp Asn Ile Ile Glu His Tyr Ser Asn Glu Asp Thr Phe Ile 
        595                 600                 605             


Leu Asn Met Glu Ser Met Val Glu Gly Phe Lys Val Thr Leu Met Glu 
    610                 615                 620                 


Ile 
625 


<210>  4713
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRHPR__Homo_sapiens__NP_036335

<400>  4713

Met Arg Pro Val Arg Leu Met Lys Val Phe Val Thr Arg Arg Ile Pro 
1               5                   10                  15      


Ala Glu Gly Arg Val Ala Leu Ala Arg Ala Ala Asp Cys Glu Val Glu 
            20                  25                  30          


Gln Trp Asp Ser Asp Glu Pro Ile Pro Ala Lys Glu Leu Glu Arg Gly 
        35                  40                  45              


Val Ala Gly Ala His Gly Leu Leu Cys Leu Leu Ser Asp His Val Asp 
    50                  55                  60                  


Lys Arg Ile Leu Asp Ala Ala Gly Ala Asn Leu Lys Val Ile Ser Thr 
65                  70                  75                  80  


Met Ser Val Gly Ile Asp His Leu Ala Leu Asp Glu Ile Lys Lys Arg 
                85                  90                  95      


Gly Ile Arg Val Gly Tyr Thr Pro Asp Val Leu Thr Asp Thr Thr Ala 
            100                 105                 110         


Glu Leu Ala Val Ser Leu Leu Leu Thr Thr Cys Arg Arg Leu Pro Glu 
        115                 120                 125             


Ala Ile Glu Glu Val Lys Asn Gly Gly Trp Thr Ser Trp Lys Pro Leu 
    130                 135                 140                 


Trp Leu Cys Gly Tyr Gly Leu Thr Gln Ser Thr Val Gly Ile Ile Gly 
145                 150                 155                 160 


Leu Gly Arg Ile Gly Gln Ala Ile Ala Arg Arg Leu Lys Pro Phe Gly 
                165                 170                 175     


Val Gln Arg Phe Leu Tyr Thr Gly Arg Gln Pro Arg Pro Glu Glu Ala 
            180                 185                 190         


Ala Glu Phe Gln Ala Glu Phe Val Ser Thr Pro Glu Leu Ala Ala Gln 
        195                 200                 205             


Ser Asp Phe Ile Val Val Ala Cys Ser Leu Thr Pro Ala Thr Glu Gly 
    210                 215                 220                 


Leu Cys Asn Lys Asp Phe Phe Gln Lys Met Lys Glu Thr Ala Val Phe 
225                 230                 235                 240 


Ile Asn Ile Ser Arg Gly Asp Val Val Asn Gln Asp Asp Leu Tyr Gln 
                245                 250                 255     


Ala Leu Ala Ser Gly Lys Ile Ala Ala Ala Gly Leu Asp Val Thr Ser 
            260                 265                 270         


Pro Glu Pro Leu Pro Thr Asn His Pro Leu Leu Thr Leu Lys Asn Cys 
        275                 280                 285             


Val Ile Leu Pro His Ile Gly Ser Ala Thr His Arg Thr Arg Asn Thr 
    290                 295                 300                 


Met Ser Leu Leu Ala Ala Asn Asn Leu Leu Ala Gly Leu Arg Gly Glu 
305                 310                 315                 320 


Pro Met Pro Ser Glu Leu Lys Leu 
                325             


<210>  4714
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIA1__Homo_sapiens__NP_000818

<400>  4714

Met Gln His Ile Phe Ala Phe Phe Cys Thr Gly Phe Leu Gly Ala Val 
1               5                   10                  15      


Val Gly Ala Asn Phe Pro Asn Asn Ile Gln Ile Gly Gly Leu Phe Pro 
            20                  25                  30          


Asn Gln Gln Ser Gln Glu His Ala Ala Phe Arg Phe Ala Leu Ser Gln 
        35                  40                  45              


Leu Thr Glu Pro Pro Lys Leu Leu Pro Gln Ile Asp Ile Val Asn Ile 
    50                  55                  60                  


Ser Asp Ser Phe Glu Met Thr Tyr Arg Phe Cys Ser Gln Phe Ser Lys 
65                  70                  75                  80  


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Glu Arg Arg Thr Val Asn Met 
                85                  90                  95      


Leu Thr Ser Phe Cys Gly Ala Leu His Val Cys Phe Ile Thr Pro Ser 
            100                 105                 110         


Phe Pro Val Asp Thr Ser Asn Gln Phe Val Leu Gln Leu Arg Pro Glu 
        115                 120                 125             


Leu Gln Asp Ala Leu Ile Ser Ile Ile Asp His Tyr Lys Trp Gln Lys 
    130                 135                 140                 


Phe Val Tyr Ile Tyr Asp Ala Asp Arg Gly Leu Ser Val Leu Gln Lys 
145                 150                 155                 160 


Val Leu Asp Thr Ala Ala Glu Lys Asn Trp Gln Val Thr Ala Val Asn 
                165                 170                 175     


Ile Leu Thr Thr Thr Glu Glu Gly Tyr Arg Met Leu Phe Gln Asp Leu 
            180                 185                 190         


Glu Lys Lys Lys Glu Arg Leu Val Val Val Asp Cys Glu Ser Glu Arg 
        195                 200                 205             


Leu Asn Ala Ile Leu Gly Gln Ile Ile Lys Leu Glu Lys Asn Gly Ile 
    210                 215                 220                 


Gly Tyr His Tyr Ile Leu Ala Asn Leu Gly Phe Met Asp Ile Asp Leu 
225                 230                 235                 240 


Asn Lys Phe Lys Glu Ser Gly Ala Asn Val Thr Gly Phe Gln Leu Val 
                245                 250                 255     


Asn Tyr Thr Asp Thr Ile Pro Ala Lys Ile Met Gln Gln Trp Lys Asn 
            260                 265                 270         


Ser Asp Ala Arg Asp His Thr Arg Val Asp Trp Lys Arg Pro Lys Tyr 
        275                 280                 285             


Thr Ser Ala Leu Thr Tyr Asp Gly Val Lys Val Met Ala Glu Ala Phe 
    290                 295                 300                 


Gln Ser Leu Arg Arg Gln Arg Ile Asp Ile Ser Arg Arg Gly Asn Ala 
305                 310                 315                 320 


Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Gly Gln Gly Ile Asp 
                325                 330                 335     


Ile Gln Arg Ala Leu Gln Gln Val Arg Phe Glu Gly Leu Thr Gly Asn 
            340                 345                 350         


Val Gln Phe Asn Glu Lys Gly Arg Arg Thr Asn Tyr Thr Leu His Val 
        355                 360                 365             


Ile Glu Met Lys His Asp Gly Ile Arg Lys Ile Gly Tyr Trp Asn Glu 
    370                 375                 380                 


Asp Asp Lys Phe Val Pro Ala Ala Thr Asp Ala Gln Ala Gly Gly Asp 
385                 390                 395                 400 


Asn Ser Ser Val Gln Asn Arg Thr Tyr Ile Val Thr Thr Ile Leu Glu 
                405                 410                 415     


Asp Pro Tyr Val Met Leu Lys Lys Asn Ala Asn Gln Phe Glu Gly Asn 
            420                 425                 430         


Asp Arg Tyr Glu Gly Tyr Cys Val Glu Leu Ala Ala Glu Ile Ala Lys 
        435                 440                 445             


His Val Gly Tyr Ser Tyr Arg Leu Glu Ile Val Ser Asp Gly Lys Tyr 
    450                 455                 460                 


Gly Ala Arg Asp Pro Asp Thr Lys Ala Trp Asn Gly Met Val Gly Glu 
465                 470                 475                 480 


Leu Val Tyr Gly Arg Ala Asp Val Ala Val Ala Pro Leu Thr Ile Thr 
                485                 490                 495     


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
            500                 505                 510         


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
        515                 520                 525             


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
    530                 535                 540                 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
545                 550                 555                 560 


Ser Pro Tyr Glu Trp His Ser Glu Glu Phe Glu Glu Gly Arg Asp Gln 
                565                 570                 575     


Thr Thr Ser Asp Gln Ser Asn Glu Phe Gly Ile Phe Asn Ser Leu Trp 
            580                 585                 590         


Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser Pro Arg 
        595                 600                 605             


Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe Thr Leu 
    610                 615                 620                 


Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Thr Val 
625                 630                 635                 640 


Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala Lys Gln 
                645                 650                 655     


Thr Glu Ile Ala Tyr Gly Thr Leu Glu Ala Gly Ser Thr Lys Glu Phe 
            660                 665                 670         


Phe Arg Arg Ser Lys Ile Ala Val Phe Glu Lys Met Trp Thr Tyr Met 
        675                 680                 685             


Lys Ser Ala Glu Pro Ser Val Phe Val Arg Thr Thr Glu Glu Gly Met 
    690                 695                 700                 


Ile Arg Val Arg Lys Ser Lys Gly Lys Tyr Ala Tyr Leu Leu Glu Ser 
705                 710                 715                 720 


Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr Met Lys 
                725                 730                 735     


Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Ile Ala Thr Pro Lys 
            740                 745                 750         


Gly Ser Ala Leu Arg Asn Pro Val Asn Leu Ala Val Leu Lys Leu Asn 
        755                 760                 765             


Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr Asp Lys 
    770                 775                 780                 


Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr Ser Ala 
785                 790                 795                 800 


Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Ile Gly Gly 
                805                 810                 815     


Leu Gly Leu Ala Met Leu Val Ala Leu Ile Glu Phe Cys Tyr Lys Ser 
            820                 825                 830         


Arg Ser Glu Ser Lys Arg Met Lys Gly Phe Cys Leu Ile Pro Gln Gln 
        835                 840                 845             


Ser Ile Asn Glu Ala Ile Arg Thr Ser Thr Leu Pro Arg Asn Ser Gly 
    850                 855                 860                 


Ala Gly Ala Ser Ser Gly Gly Ser Gly Glu Asn Gly Arg Val Val Ser 
865                 870                 875                 880 


His Asp Phe Pro Lys Ser Met Gln Ser Ile Pro Cys Met Ser His Ser 
                885                 890                 895     


Ser Gly Met Pro Leu Gly Ala Thr Gly Leu 
            900                 905     


<210>  4715
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIA2__Homo_sapiens__NP_000817

<400>  4715

Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp 
1               5                   10                  15      


Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met 
        35                  40                  45              


Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn 
    50                  55                  60                  


Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln 
65                  70                  75                  80  


Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser 
                85                  90                  95      


Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile 
            100                 105                 110         


Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met 
        115                 120                 125             


Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln 
    130                 135                 140                 


Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr 
145                 150                 155                 160 


Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr 
                165                 170                 175     


Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr 
            180                 185                 190         


Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile 
        195                 200                 205             


Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile 
    210                 215                 220                 


Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu 
225                 230                 235                 240 


Gly Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn 
                245                 250                 255     


Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys 
            260                 265                 270         


Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala 
        275                 280                 285             


His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val 
    290                 295                 300                 


Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu 
305                 310                 315                 320 


Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val 
                325                 330                 335     


Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln 
            340                 345                 350         


Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg 
        355                 360                 365             


Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg 
    370                 375                 380                 


Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr 
385                 390                 395                 400 


Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val 
                405                 410                 415     


Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn 
            420                 425                 430         


His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp 
        435                 440                 445             


Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr 
    450                 455                 460                 


Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile 
465                 470                 475                 480 


Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala 
                485                 490                 495     


Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro 
        515                 520                 525             


Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr 
    530                 535                 540                 


Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val 
545                 550                 555                 560 


Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu 
                565                 570                 575     


Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe 
            580                 585                 590         


Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Arg Gln 
        595                 600                 605             


Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly 
    610                 615                 620                 


Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
625                 630                 635                 640 


Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser 
                645                 650                 655     


Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp 
            660                 665                 670         


Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe 
        675                 680                 685             


Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val 
    690                 695                 700                 


Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys 
705                 710                 715                 720 


Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg 
                725                 730                 735     


Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly 
            740                 745                 750         


Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val Asn 
        755                 760                 765             


Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys 
    770                 775                 780                 


Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly 
785                 790                 795                 800 


Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val 
                805                 810                 815     


Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu 
            820                 825                 830         


Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val 
        835                 840                 845             


Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln 
    850                 855                 860                 


Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser 
865                 870                 875                 880 


Val Lys Ile 
            


<210>  4716
<211>  894
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIA3__Homo_sapiens__NP_000819

<400>  4716

Met Ala Arg Gln Lys Lys Met Gly Gln Ser Val Leu Arg Ala Val Phe 
1               5                   10                  15      


Phe Leu Val Leu Gly Leu Leu Gly His Ser His Gly Gly Phe Pro Asn 
            20                  25                  30          


Thr Ile Ser Ile Gly Gly Leu Phe Met Arg Asn Thr Val Gln Glu His 
        35                  40                  45              


Ser Ala Phe Arg Phe Ala Val Gln Leu Tyr Asn Thr Asn Gln Asn Thr 
    50                  55                  60                  


Thr Glu Lys Pro Phe His Leu Asn Tyr His Val Asp His Leu Asp Ser 
65                  70                  75                  80  


Ser Asn Ser Phe Ser Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg 
                85                  90                  95      


Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Gln Met Ser Met Asn Thr 
            100                 105                 110         


Leu Thr Ser Phe Cys Gly Ala Leu His Thr Ser Phe Val Thr Pro Ser 
        115                 120                 125             


Phe Pro Thr Asp Ala Asp Val Gln Phe Val Ile Gln Met Arg Pro Ala 
    130                 135                 140                 


Leu Lys Gly Ala Ile Leu Ser Leu Leu Gly His Tyr Lys Trp Glu Lys 
145                 150                 155                 160 


Phe Val Tyr Leu Tyr Asp Thr Glu Arg Gly Phe Ser Ile Leu Gln Ala 
                165                 170                 175     


Ile Met Glu Ala Ala Val Gln Asn Asn Trp Gln Val Thr Ala Arg Ser 
            180                 185                 190         


Val Gly Asn Ile Lys Asp Val Gln Glu Phe Arg Arg Ile Ile Glu Glu 
        195                 200                 205             


Met Asp Arg Arg Gln Glu Lys Arg Tyr Leu Ile Asp Cys Glu Val Glu 
    210                 215                 220                 


Arg Ile Asn Thr Ile Leu Glu Gln Val Val Ile Leu Gly Lys His Ser 
225                 230                 235                 240 


Arg Gly Tyr His Tyr Met Leu Ala Asn Leu Gly Phe Thr Asp Ile Leu 
                245                 250                 255     


Leu Glu Arg Val Met His Gly Gly Ala Asn Ile Thr Gly Phe Gln Ile 
            260                 265                 270         


Val Asn Asn Glu Asn Pro Met Val Gln Gln Phe Ile Gln Arg Trp Val 
        275                 280                 285             


Arg Leu Asp Glu Arg Glu Phe Pro Glu Ala Lys Asn Ala Pro Leu Lys 
    290                 295                 300                 


Tyr Thr Ser Ala Leu Thr His Asp Ala Ile Leu Val Ile Ala Glu Ala 
305                 310                 315                 320 


Phe Arg Tyr Leu Arg Arg Gln Arg Val Asp Val Ser Arg Arg Gly Ser 
                325                 330                 335     


Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Ser Gln Gly Ile 
            340                 345                 350         


Asp Ile Glu Arg Ala Leu Lys Met Val Gln Val Gln Gly Met Thr Gly 
        355                 360                 365             


Asn Ile Gln Phe Asp Thr Tyr Gly Arg Arg Thr Asn Tyr Thr Ile Asp 
    370                 375                 380                 


Val Tyr Glu Met Lys Val Ser Gly Ser Arg Lys Ala Gly Tyr Trp Asn 
385                 390                 395                 400 


Glu Tyr Glu Arg Phe Val Pro Phe Ser Asp Gln Gln Ile Ser Asn Asp 
                405                 410                 415     


Ser Ala Ser Ser Glu Asn Arg Thr Ile Val Val Thr Thr Ile Leu Glu 
            420                 425                 430         


Ser Pro Tyr Val Met Tyr Lys Lys Asn His Glu Gln Leu Glu Gly Asn 
        435                 440                 445             


Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Tyr Glu Ile Ala Lys 
    450                 455                 460                 


His Val Arg Ile Lys Tyr Lys Leu Ser Ile Val Gly Asp Gly Lys Tyr 
465                 470                 475                 480 


Gly Ala Arg Asp Pro Glu Thr Lys Ile Trp Asn Gly Met Val Gly Glu 
                485                 490                 495     


Leu Val Tyr Gly Arg Ala Asp Ile Ala Val Ala Pro Leu Thr Ile Thr 
            500                 505                 510         


Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met Ser Leu 
        515                 520                 525             


Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro Gly Val 
    530                 535                 540                 


Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu Ile Trp Met Cys Ile Val 
545                 550                 555                 560 


Phe Ala Tyr Ile Gly Val Ser Val Val Leu Phe Leu Val Ser Arg Phe 
                565                 570                 575     


Ser Pro Tyr Glu Trp His Leu Glu Asp Asn Asn Glu Glu Pro Arg Asp 
            580                 585                 590         


Pro Gln Ser Pro Pro Asp Pro Pro Asn Glu Phe Gly Ile Phe Asn Ser 
        595                 600                 605             


Leu Trp Phe Ser Leu Gly Ala Phe Met Gln Gln Gly Cys Asp Ile Ser 
    610                 615                 620                 


Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly Val Trp Trp Phe Phe 
625                 630                 635                 640 


Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser Ala Glu Asp Leu Ala 
            660                 665                 670         


Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp Ser Gly Ser Thr Lys 
        675                 680                 685             


Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Tyr Glu Lys Met Trp Ser 
    690                 695                 700                 


Tyr Met Lys Ser Ala Glu Pro Ser Val Phe Thr Lys Thr Thr Ala Asp 
705                 710                 715                 720 


Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys Phe Ala Phe Leu Leu 
                725                 730                 735     


Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg Lys Pro Cys Asp Thr 
            740                 745                 750         


Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly Tyr Gly Val Ala Thr 
        755                 760                 765             


Pro Lys Gly Ser Ala Leu Gly Asn Ala Val Asn Leu Ala Val Leu Lys 
    770                 775                 780                 


Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu Lys Asn Lys Trp Trp Tyr 
785                 790                 795                 800 


Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly Asp Ser Lys Asp Lys Thr 
                805                 810                 815     


Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val Phe Tyr Ile Leu Val 
            820                 825                 830         


Gly Gly Leu Gly Leu Ala Met Met Val Ala Leu Ile Glu Phe Cys Tyr 
        835                 840                 845             


Lys Ser Arg Ala Glu Ser Lys Arg Met Lys Leu Thr Lys Asn Thr Gln 
    850                 855                 860                 


Asn Phe Lys Pro Ala Pro Ala Thr Asn Thr Gln Asn Tyr Ala Thr Tyr 
865                 870                 875                 880 


Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu Ser Val Lys Ile 
                885                 890                 


<210>  4717
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIA4__Homo_sapiens__NP_001070711

<400>  4717

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Gly Asn Ala Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Asn Glu Gln Gly Leu Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Asp Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Val Ala Lys Ser Ala Gln Thr Phe Asn Pro Thr Ser Ser Gln Asn Thr 
    850                 855                 860                 


Gln Asn Leu Ala Thr Tyr Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu 
865                 870                 875                 880 


Ser Ile Lys Ile 
                


<210>  4718
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRID1__Homo_sapiens__NP_060021

<400>  4718

Met Glu Ala Leu Thr Leu Trp Leu Leu Pro Trp Ile Cys Gln Cys Val 
1               5                   10                  15      


Ser Val Arg Ala Asp Ser Ile Ile His Ile Gly Ala Ile Phe Glu Glu 
            20                  25                  30          


Asn Ala Ala Lys Asp Asp Arg Val Phe Gln Leu Ala Val Ser Asp Leu 
        35                  40                  45              


Ser Leu Asn Asp Asp Ile Leu Gln Ser Glu Lys Ile Thr Tyr Ser Ile 
    50                  55                  60                  


Lys Val Ile Glu Ala Asn Asn Pro Phe Gln Ala Val Gln Glu Ala Cys 
65                  70                  75                  80  


Asp Leu Met Thr Gln Gly Ile Leu Ala Leu Val Thr Ser Thr Gly Cys 
                85                  90                  95      


Ala Ser Ala Asn Ala Leu Gln Ser Leu Thr Asp Ala Met His Ile Pro 
            100                 105                 110         


His Leu Phe Val Gln Arg Asn Pro Gly Gly Ser Pro Arg Thr Ala Cys 
        115                 120                 125             


His Leu Asn Pro Ser Pro Asp Gly Glu Ala Tyr Thr Leu Ala Ser Arg 
    130                 135                 140                 


Pro Pro Val Arg Leu Asn Asp Val Met Leu Arg Leu Val Thr Glu Leu 
145                 150                 155                 160 


Arg Trp Gln Lys Phe Val Met Phe Tyr Asp Ser Glu Tyr Asp Ile Arg 
                165                 170                 175     


Gly Leu Gln Ser Phe Leu Asp Gln Ala Ser Arg Leu Gly Leu Asp Val 
            180                 185                 190         


Ser Leu Gln Lys Val Asp Lys Asn Ile Ser His Val Phe Thr Ser Leu 
        195                 200                 205             


Phe Thr Thr Met Lys Thr Glu Glu Leu Asn Arg Tyr Arg Asp Thr Leu 
    210                 215                 220                 


Arg Arg Ala Ile Leu Leu Leu Ser Pro Gln Gly Ala His Ser Phe Ile 
225                 230                 235                 240 


Asn Glu Ala Val Glu Thr Asn Leu Ala Ser Lys Asp Ser His Trp Val 
                245                 250                 255     


Phe Val Asn Glu Glu Ile Ser Asp Pro Glu Ile Leu Asp Leu Val His 
            260                 265                 270         


Ser Ala Leu Gly Arg Met Thr Val Val Arg Gln Ile Phe Pro Ser Ala 
        275                 280                 285             


Lys Asp Asn Gln Lys Cys Thr Arg Asn Asn His Arg Ile Ser Ser Leu 
    290                 295                 300                 


Leu Cys Asp Pro Gln Glu Gly Tyr Leu Gln Met Leu Gln Ile Ser Asn 
305                 310                 315                 320 


Leu Tyr Leu Tyr Asp Ser Val Leu Met Leu Ala Asn Ala Phe His Arg 
                325                 330                 335     


Lys Leu Glu Asp Arg Lys Trp His Ser Met Ala Ser Leu Asn Cys Ile 
            340                 345                 350         


Arg Lys Ser Thr Lys Pro Trp Asn Gly Gly Arg Ser Met Leu Asp Thr 
        355                 360                 365             


Ile Lys Lys Gly His Ile Thr Gly Leu Thr Gly Val Met Glu Phe Arg 
    370                 375                 380                 


Glu Asp Ser Ser Asn Pro Tyr Val Gln Phe Glu Ile Leu Gly Thr Thr 
385                 390                 395                 400 


Tyr Ser Glu Thr Phe Gly Lys Asp Met Arg Lys Leu Ala Thr Trp Asp 
                405                 410                 415     


Ser Glu Lys Gly Leu Asn Gly Ser Leu Gln Glu Arg Pro Met Gly Ser 
            420                 425                 430         


Arg Leu Gln Gly Leu Thr Leu Lys Val Val Thr Val Leu Glu Glu Pro 
        435                 440                 445             


Phe Val Met Val Ala Glu Asn Ile Leu Gly Gln Pro Lys Arg Tyr Lys 
    450                 455                 460                 


Gly Phe Ser Ile Asp Val Leu Asp Ala Leu Ala Lys Ala Leu Gly Phe 
465                 470                 475                 480 


Lys Tyr Glu Ile Tyr Gln Ala Pro Asp Gly Arg Tyr Gly His Gln Leu 
                485                 490                 495     


His Asn Thr Ser Trp Asn Gly Met Ile Gly Glu Leu Ile Ser Lys Arg 
            500                 505                 510         


Ala Asp Leu Ala Ile Ser Ala Ile Thr Ile Thr Pro Glu Arg Glu Ser 
        515                 520                 525             


Val Val Asp Phe Ser Lys Arg Tyr Met Asp Tyr Ser Val Gly Ile Leu 
    530                 535                 540                 


Ile Lys Lys Pro Glu Glu Lys Ile Ser Ile Phe Ser Leu Phe Ala Pro 
545                 550                 555                 560 


Phe Asp Phe Ala Val Trp Ala Cys Ile Ala Ala Ala Ile Pro Val Val 
                565                 570                 575     


Gly Val Leu Ile Phe Val Leu Asn Arg Ile Gln Ala Val Arg Ala Gln 
            580                 585                 590         


Ser Ala Ala Gln Pro Arg Pro Ser Ala Ser Ala Thr Leu His Ser Ala 
        595                 600                 605             


Ile Trp Ile Val Tyr Gly Ala Phe Val Gln Gln Gly Gly Glu Ser Ser 
    610                 615                 620                 


Val Asn Ser Met Ala Met Arg Ile Val Met Gly Ser Trp Trp Leu Phe 
625                 630                 635                 640 


Thr Leu Ile Val Cys Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu 
                645                 650                 655     


Thr Val Ser Arg Met Asp Asn Pro Ile Arg Thr Phe Gln Asp Leu Ser 
            660                 665                 670         


Lys Gln Val Glu Met Ser Tyr Gly Thr Val Arg Asp Ser Ala Val Tyr 
        675                 680                 685             


Glu Tyr Phe Arg Ala Lys Gly Thr Asn Pro Leu Glu Gln Asp Ser Thr 
    690                 695                 700                 


Phe Ala Glu Leu Trp Arg Thr Ile Ser Lys Asn Gly Gly Ala Asp Asn 
705                 710                 715                 720 


Cys Val Ser Ser Pro Ser Glu Gly Ile Arg Lys Ala Lys Lys Gly Asn 
                725                 730                 735     


Tyr Ala Phe Leu Trp Asp Val Ala Val Val Glu Tyr Ala Ala Leu Thr 
            740                 745                 750         


Asp Asp Asp Cys Ser Val Thr Val Ile Gly Asn Ser Ile Ser Ser Lys 
        755                 760                 765             


Gly Tyr Gly Ile Ala Leu Gln His Gly Ser Pro Tyr Arg Asp Leu Phe 
    770                 775                 780                 


Ser Gln Arg Ile Leu Glu Leu Gln Asp Thr Gly Asp Leu Asp Val Leu 
785                 790                 795                 800 


Lys Gln Lys Trp Trp Pro His Met Gly Arg Cys Asp Leu Thr Ser His 
                805                 810                 815     


Ala Ser Ala Gln Ala Asp Gly Lys Ser Leu Lys Leu His Ser Phe Ala 
            820                 825                 830         


Gly Val Phe Cys Ile Leu Ala Ile Gly Leu Leu Leu Ala Cys Leu Val 
        835                 840                 845             


Ala Ala Leu Glu Leu Trp Trp Asn Ser Asn Arg Cys His Gln Glu Thr 
    850                 855                 860                 


Pro Lys Glu Asp Lys Glu Val Asn Leu Glu Gln Val His Arg Arg Met 
865                 870                 875                 880 


Asn Ser Leu Met Asp Glu Asp Ile Ala His Lys Gln Ile Ser Pro Ala 
                885                 890                 895     


Ser Ile Glu Leu Ser Ala Leu Glu Met Gly Gly Leu Ala Pro Thr Gln 
            900                 905                 910         


Thr Leu Glu Pro Thr Arg Glu Tyr Gln Asn Thr Gln Leu Ser Val Ser 
        915                 920                 925             


Thr Phe Leu Pro Glu Gln Ser Ser His Gly Thr Ser Arg Thr Leu Ser 
    930                 935                 940                 


Ser Gly Pro Ser Ser Asn Leu Pro Leu Pro Leu Ser Ser Ser Ala Thr 
945                 950                 955                 960 


Met Pro Ser Met Gln Cys Lys His Arg Ser Pro Asn Gly Gly Leu Phe 
                965                 970                 975     


Arg Gln Ser Pro Val Lys Thr Pro Ile Pro Met Ser Phe Gln Pro Val 
            980                 985                 990         


Pro Gly Gly Val Leu Pro Glu Ala  Leu Asp Thr Ser His  Gly Thr Ser 
        995                 1000                 1005             


Ile 
    


<210>  4719
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRID2__Homo_sapiens__NP_001273767

<400>  4719

Met Glu Val Phe Pro Phe Leu Leu Val Leu Ser Val Trp Trp Ser Arg 
1               5                   10                  15      


Thr Trp Asp Ser Ala Asn Ala Asp Ser Ile Ile His Ile Gly Ala Ile 
            20                  25                  30          


Phe Asp Glu Ser Ala Lys Lys Asp Asp Glu Val Phe Arg Thr Ala Val 
        35                  40                  45              


Gly Asp Leu Asn Gln Asn Glu Glu Ile Leu Gln Thr Glu Lys Ile Thr 
    50                  55                  60                  


Phe Ser Val Thr Phe Val Asp Gly Asn Asn Pro Phe Gln Ala Val Gln 
65                  70                  75                  80  


Glu Asp Ile Arg Gly Ile Gln Glu Phe Leu Asp Lys Val Ser Gln Gln 
                85                  90                  95      


Gly Met Asp Val Ala Leu Gln Lys Val Glu Asn Asn Ile Asn Lys Met 
            100                 105                 110         


Ile Thr Thr Leu Phe Asp Thr Met Arg Ile Glu Glu Leu Asn Arg Tyr 
        115                 120                 125             


Arg Asp Thr Leu Arg Arg Ala Ile Leu Val Met Asn Pro Ala Thr Ala 
    130                 135                 140                 


Lys Ser Phe Ile Thr Glu Val Val Glu Thr Asn Leu Val Ala Phe Asp 
145                 150                 155                 160 


Cys His Trp Ile Ile Ile Asn Glu Glu Ile Asn Asp Val Asp Val Gln 
                165                 170                 175     


Glu Leu Val Arg Arg Ser Ile Gly Arg Leu Thr Ile Ile Arg Gln Thr 
            180                 185                 190         


Phe Pro Val Pro Gln Asn Ile Ser Gln Arg Cys Phe Arg Gly Asn His 
        195                 200                 205             


Arg Ile Ser Ser Thr Leu Cys Asp Pro Lys Asp Pro Phe Ala Gln Asn 
    210                 215                 220                 


Met Glu Ile Ser Asn Leu Tyr Ile Tyr Asp Thr Val Leu Leu Leu Ala 
225                 230                 235                 240 


Asn Ala Phe His Lys Lys Leu Glu Asp Arg Lys Trp His Ser Met Ala 
                245                 250                 255     


Ser Leu Ser Cys Ile Arg Lys Asn Ser Lys Pro Trp Gln Gly Gly Arg 
            260                 265                 270         


Ser Met Leu Glu Thr Ile Lys Lys Gly Gly Val Ser Gly Leu Thr Gly 
        275                 280                 285             


Glu Leu Glu Phe Gly Glu Asn Gly Gly Asn Pro Asn Val His Phe Glu 
    290                 295                 300                 


Ile Leu Gly Thr Asn Tyr Gly Glu Glu Leu Gly Arg Gly Val Arg Lys 
305                 310                 315                 320 


Leu Gly Cys Trp Asn Pro Val Thr Gly Leu Asn Gly Ser Leu Thr Asp 
                325                 330                 335     


Lys Lys Leu Glu Asn Asn Met Arg Gly Val Val Leu Arg Val Val Thr 
            340                 345                 350         


Val Leu Glu Glu Pro Phe Val Met Val Ser Glu Asn Val Leu Gly Lys 
        355                 360                 365             


Pro Lys Lys Tyr Gln Gly Phe Ser Ile Asp Val Leu Asp Ala Leu Ser 
    370                 375                 380                 


Asn Tyr Leu Gly Phe Asn Tyr Glu Ile Tyr Val Ala Pro Asp His Lys 
385                 390                 395                 400 


Tyr Gly Ser Pro Gln Glu Asp Gly Thr Trp Asn Gly Leu Val Gly Glu 
                405                 410                 415     


Leu Val Phe Lys Arg Ala Asp Ile Gly Ile Ser Ala Leu Thr Ile Thr 
            420                 425                 430         


Pro Asp Arg Glu Asn Val Val Asp Phe Thr Thr Arg Tyr Met Asp Tyr 
        435                 440                 445             


Ser Val Gly Val Leu Leu Arg Arg Ala Glu Lys Thr Val Asp Met Phe 
    450                 455                 460                 


Ala Cys Leu Ala Pro Phe Asp Leu Ser Leu Trp Ala Cys Ile Ala Gly 
465                 470                 475                 480 


Thr Val Leu Leu Val Gly Leu Leu Val Tyr Leu Leu Asn Trp Leu Asn 
                485                 490                 495     


Pro Pro Arg Leu Gln Met Gly Ser Met Thr Ser Thr Thr Leu Tyr Asn 
            500                 505                 510         


Ser Met Trp Phe Val Tyr Gly Ser Phe Val Gln Gln Gly Gly Glu Val 
        515                 520                 525             


Pro Tyr Thr Thr Leu Ala Thr Arg Met Met Met Gly Ala Trp Trp Leu 
    530                 535                 540                 


Phe Ala Leu Ile Val Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala Phe 
545                 550                 555                 560 


Leu Thr Ile Thr Arg Ile Glu Ser Ser Ile Gln Ser Leu Gln Asp Leu 
                565                 570                 575     


Ser Lys Gln Thr Glu Ile Pro Tyr Gly Thr Val Leu Asp Ser Ala Val 
            580                 585                 590         


Tyr Glu His Val Arg Met Lys Gly Leu Asn Pro Phe Glu Arg Asp Ser 
        595                 600                 605             


Met Tyr Ser Gln Met Trp Arg Met Ile Asn Arg Ser Asn Gly Ser Glu 
    610                 615                 620                 


Asn Asn Val Leu Glu Ser Gln Ala Gly Ile Gln Lys Val Lys Tyr Gly 
625                 630                 635                 640 


Asn Tyr Ala Phe Val Trp Asp Ala Ala Val Leu Glu Tyr Val Ala Ile 
                645                 650                 655     


Asn Asp Pro Asp Cys Ser Phe Tyr Thr Ile Gly Asn Thr Val Ala Asp 
            660                 665                 670         


Arg Gly Tyr Gly Ile Ala Leu Gln His Gly Ser Pro Tyr Arg Asp Val 
        675                 680                 685             


Phe Ser Gln Arg Ile Leu Glu Leu Gln Gln Asn Gly Asp Met Asp Ile 
    690                 695                 700                 


Leu Lys His Lys Trp Trp Pro Lys Asn Gly Gln Cys Asp Leu Tyr Ser 
705                 710                 715                 720 


Ser Val Asp Thr Lys Gln Lys Gly Gly Ala Leu Asp Ile Lys Ser Phe 
                725                 730                 735     


Ala Gly Val Phe Cys Ile Leu Ala Ala Gly Ile Val Leu Ser Cys Phe 
            740                 745                 750         


Ile Ala Met Leu Glu Thr Trp Trp Asn Lys Arg Lys Gly Ser Arg Val 
        755                 760                 765             


Pro Ser Lys Glu Asp Asp Lys Glu Ile Asp Leu Glu His Leu His Arg 
    770                 775                 780                 


Arg Val Asn Ser Leu Cys Thr Asp Asp Asp Ser Pro His Lys Gln Phe 
785                 790                 795                 800 


Ser Thr Ser Ser Ile Asp Leu Thr Pro Leu Asp Ile Asp Thr Leu Pro 
                805                 810                 815     


Thr Arg Gln Ala Leu Glu Gln Ile Ser Asp Phe Arg Asn Thr His Ile 
            820                 825                 830         


Thr Thr Thr Thr Phe Ile Pro Glu Gln Ile Gln Thr Leu Ser Arg Thr 
        835                 840                 845             


Leu Ser Ala Lys Ala Ala Ser Gly Phe Thr Phe Gly Asn Val Pro Glu 
    850                 855                 860                 


His Arg Thr Gly Pro Phe Arg His Arg Ala Pro Asn Gly Gly Phe Phe 
865                 870                 875                 880 


Arg Ser Pro Ile Lys Thr Met Ser Ser Ile Pro Tyr Gln Pro Thr Pro 
                885                 890                 895     


Thr Leu Gly Leu Asn Leu Gly Asn Asp Pro Asp Arg Gly Thr Ser Ile 
            900                 905                 910         


<210>  4720
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIK1__Homo_sapiens__NP_000821

<400>  4720

Met Glu His Gly Thr Leu Leu Ala Gln Pro Gly Leu Trp Thr Arg Asp 
1               5                   10                  15      


Thr Ser Trp Ala Leu Leu Tyr Phe Leu Cys Tyr Ile Leu Pro Gln Thr 
            20                  25                  30          


Ala Pro Gln Val Leu Arg Ile Gly Gly Ile Phe Glu Thr Val Glu Asn 
        35                  40                  45              


Glu Pro Val Asn Val Glu Glu Leu Ala Phe Lys Phe Ala Val Thr Ser 
    50                  55                  60                  


Ile Asn Arg Asn Arg Thr Leu Met Pro Asn Thr Thr Leu Thr Tyr Asp 
65                  70                  75                  80  


Ile Gln Arg Ile Asn Leu Phe Asp Ser Phe Glu Ala Ser Arg Arg Ala 
                85                  90                  95      


Cys Asp Gln Leu Ala Leu Gly Val Ala Ala Leu Phe Gly Pro Ser His 
            100                 105                 110         


Ser Ser Ser Val Ser Ala Val Gln Ser Ile Cys Asn Ala Leu Glu Val 
        115                 120                 125             


Pro His Ile Gln Thr Arg Trp Lys His Pro Ser Val Asp Asn Lys Asp 
    130                 135                 140                 


Leu Phe Tyr Ile Asn Leu Tyr Pro Asp Tyr Ala Ala Ile Ser Arg Ala 
145                 150                 155                 160 


Ile Leu Asp Leu Val Leu Tyr Tyr Asn Trp Lys Thr Val Thr Val Val 
                165                 170                 175     


Tyr Glu Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala 
            180                 185                 190         


Pro Ser Arg Tyr Asn Ile Lys Ile Lys Ile Arg Gln Leu Pro Ser Gly 
        195                 200                 205             


Asn Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Lys Gly Lys Glu 
    210                 215                 220                 


Phe Tyr Val Ile Phe Asp Cys Ser His Glu Thr Ala Ala Glu Ile Leu 
225                 230                 235                 240 


Lys Gln Ile Leu Phe Met Gly Met Met Thr Glu Tyr Tyr His Tyr Phe 
                245                 250                 255     


Phe Thr Thr Leu Asp Leu Phe Ala Leu Asp Leu Glu Leu Tyr Arg Tyr 
            260                 265                 270         


Ser Gly Val Asn Met Thr Gly Phe Arg Leu Leu Asn Ile Asp Asn Pro 
        275                 280                 285             


His Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala 
    290                 295                 300                 


Pro Pro Arg Pro Glu Thr Gly Leu Leu Asp Gly Met Met Thr Thr Glu 
305                 310                 315                 320 


Ala Ala Leu Met Tyr Asp Ala Val Tyr Met Val Ala Ile Ala Ser His 
                325                 330                 335     


Arg Ala Ser Gln Leu Thr Val Ser Ser Leu Gln Cys His Arg His Lys 
            340                 345                 350         


Pro Trp Arg Leu Gly Pro Arg Phe Met Asn Leu Ile Lys Glu Ala Arg 
        355                 360                 365             


Trp Asp Gly Leu Thr Gly His Ile Thr Phe Asn Lys Thr Asn Gly Leu 
    370                 375                 380                 


Arg Lys Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Glu Gly Thr 
385                 390                 395                 400 


Glu Lys Ala Ala Gly Glu Val Ser Lys His Leu Tyr Lys Val Trp Lys 
                405                 410                 415     


Lys Ile Gly Ile Trp Asn Ser Asn Ser Gly Leu Asn Met Thr Asp Ser 
            420                 425                 430         


Asn Lys Asp Lys Ser Ser Asn Ile Thr Asp Ser Leu Ala Asn Arg Thr 
        435                 440                 445             


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Met Tyr Arg Lys 
    450                 455                 460                 


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Leu 
465                 470                 475                 480 


Asp Leu Leu Lys Glu Leu Ser Asn Ile Leu Gly Phe Ile Tyr Asp Val 
                485                 490                 495     


Lys Leu Val Pro Asp Gly Lys Tyr Gly Ala Gln Asn Asp Lys Gly Glu 
            500                 505                 510         


Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Arg Ala Asp Leu Ala 
        515                 520                 525             


Val Ala Pro Leu Thr Ile Thr Tyr Val Arg Glu Lys Val Ile Asp Phe 
    530                 535                 540                 


Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys Pro 
545                 550                 555                 560 


Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser Pro 
                565                 570                 575     


Asp Ile Trp Met Tyr Val Leu Leu Ala Cys Leu Gly Val Ser Cys Val 
            580                 585                 590         


Leu Phe Val Ile Ala Arg Phe Thr Pro Tyr Glu Trp Tyr Asn Pro His 
        595                 600                 605             


Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu Leu 
    610                 615                 620                 


Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser Glu 
625                 630                 635                 640 


Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp Trp 
                645                 650                 655     


Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala Ala 
            660                 665                 670         


Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp Asp 
        675                 680                 685             


Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Arg Asp Gly Ser 
    690                 695                 700                 


Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Glu Lys Met 
705                 710                 715                 720 


Trp Ala Phe Met Ser Ser Arg Gln Gln Thr Ala Leu Val Arg Asn Ser 
                725                 730                 735     


Asp Glu Gly Ile Gln Arg Val Leu Thr Thr Asp Tyr Ala Leu Leu Met 
            740                 745                 750         


Glu Ser Thr Ser Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn Leu Thr 
        755                 760                 765             


Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr Pro 
    770                 775                 780                 


Ile Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln Leu 
785                 790                 795                 800 


Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg Gly 
                805                 810                 815     


Asn Gly Cys Pro Glu Glu Asp Asn Lys Glu Ala Ser Ala Leu Gly Val 
            820                 825                 830         


Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val Leu 
        835                 840                 845             


Ser Val Phe Val Ala Ile Gly Glu Phe Ile Tyr Lys Ser Arg Lys Asn 
    850                 855                 860                 


Asn Asp Ile Glu Gln Ala Phe Cys Phe Phe Tyr Gly Leu Gln Cys Lys 
865                 870                 875                 880 


Gln Thr His Pro Thr Asn Ser Thr Ser Gly Thr Thr Leu Ser Thr Asp 
                885                 890                 895     


Leu Glu Cys Gly Lys Leu Ile Arg Glu Glu Arg Gly Ile Arg Lys Gln 
            900                 905                 910         


Ser Ser Val His Thr Val 
        915             


<210>  4721
<211>  908
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIK2__Homo_sapiens__XP_005267002

<400>  4721

Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      


Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          


Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              


Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  


Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  


Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      


Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         


Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             


His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 


Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 


Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     


Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         


Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             


Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 


His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 


Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     


Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         


Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             


Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 


Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 


Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     


Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         


Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             


Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 


Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 


Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Ser 
                405                 410                 415     


Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         


Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             


Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 


Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 


Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     


Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         


Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 


Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 


Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     


Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         


His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             


Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 


Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 


Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     


Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         


Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             


Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 


Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 


Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     


Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         


Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             


Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 


Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 


Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     


Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         


Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             


Asn Ala Gln Leu Glu Lys Arg Ser Phe Cys Ser Ala Met Val Glu Glu 
    850                 855                 860                 


Leu Arg Met Ser Leu Lys Cys Gln Arg Arg Leu Lys His Lys Pro Gln 
865                 870                 875                 880 


Ala Pro Val Ile Val Lys Thr Glu Glu Val Ile Asn Met His Thr Phe 
                885                 890                 895     


Asn Asp Arg Arg Leu Pro Gly Lys Glu Thr Met Ala 
            900                 905             


<210>  4722
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIK4__Homo_sapiens__NP_001269399

<400>  4722

Met Pro Arg Val Ser Ala Pro Leu Val Leu Leu Pro Ala Trp Leu Val 
1               5                   10                  15      


Met Val Ala Cys Ser Pro His Ser Leu Arg Ile Ala Ala Ile Leu Asp 
            20                  25                  30          


Asp Pro Met Glu Cys Ser Arg Gly Glu Arg Leu Ser Ile Thr Leu Ala 
        35                  40                  45              


Lys Asn Arg Ile Asn Arg Ala Pro Glu Arg Leu Gly Lys Ala Lys Val 
    50                  55                  60                  


Glu Val Asp Ile Phe Glu Leu Leu Arg Asp Ser Glu Tyr Glu Thr Ala 
65                  70                  75                  80  


Glu Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ala Val Leu Gly 
                85                  90                  95      


Pro Ser Ser Ser Pro Ala Ser Ser Ser Ile Ile Ser Asn Ile Cys Gly 
            100                 105                 110         


Glu Lys Glu Val Pro His Phe Lys Val Ala Pro Glu Glu Phe Val Lys 
        115                 120                 125             


Phe Gln Phe Gln Arg Phe Thr Thr Leu Asn Leu His Pro Ser Asn Thr 
    130                 135                 140                 


Asp Ile Ser Val Ala Val Ala Gly Ile Leu Asn Phe Phe Asn Cys Thr 
145                 150                 155                 160 


Thr Ala Cys Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Asn Leu Glu 
                165                 170                 175     


Lys Leu Leu Arg Gln Phe Leu Ile Ser Lys Asp Thr Leu Ser Val Arg 
            180                 185                 190         


Met Leu Asp Asp Thr Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg 
        195                 200                 205             


Asp Asp Lys Thr Ala Thr Ile Ile Ile His Ala Asn Ala Ser Met Ser 
    210                 215                 220                 


His Thr Ile Leu Leu Lys Ala Ala Glu Leu Gly Met Val Ser Ala Tyr 
225                 230                 235                 240 


Tyr Thr Tyr Ile Phe Thr Asn Leu Glu Phe Ser Leu Gln Arg Met Asp 
                245                 250                 255     


Ser Leu Val Asp Asp Arg Val Asn Ile Leu Gly Phe Ser Ile Phe Asn 
            260                 265                 270         


Gln Ser His Ala Phe Phe Gln Glu Phe Ala Gln Ser Leu Asn Gln Ser 
        275                 280                 285             


Trp Gln Glu Asn Cys Asp His Val Pro Phe Thr Gly Pro Ala Leu Ser 
    290                 295                 300                 


Ser Ala Leu Leu Phe Asp Ala Val Tyr Ala Val Val Thr Ala Val Gln 
305                 310                 315                 320 


Glu Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ser Cys Gly 
                325                 330                 335     


Ser Ala Gln Ile Trp Gln His Gly Thr Ser Leu Met Asn Tyr Leu Arg 
            340                 345                 350         


Met Val Glu Leu Glu Gly Leu Thr Gly His Ile Glu Phe Asn Ser Lys 
        355                 360                 365             


Gly Gln Arg Ser Asn Tyr Ala Leu Lys Ile Leu Gln Phe Thr Arg Asn 
    370                 375                 380                 


Gly Phe Arg Gln Ile Gly Gln Trp His Val Ala Glu Gly Leu Ser Met 
385                 390                 395                 400 


Asp Ser His Leu Tyr Ala Ser Asn Ile Ser Asp Thr Leu Phe Asn Thr 
                405                 410                 415     


Thr Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Leu Met Leu Lys 
            420                 425                 430         


Gly Asn His Gln Glu Met Glu Gly Asn Asp Arg Tyr Glu Gly Phe Cys 
        435                 440                 445             


Val Asp Met Leu Lys Glu Leu Ala Glu Ile Leu Arg Phe Asn Tyr Lys 
    450                 455                 460                 


Ile Arg Leu Val Gly Asp Gly Val Tyr Gly Val Pro Glu Ala Asn Gly 
465                 470                 475                 480 


Thr Trp Thr Gly Met Val Gly Glu Leu Ile Ala Arg Lys Ala Asp Leu 
                485                 490                 495     


Ala Val Ala Gly Leu Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Val 
        515                 520                 525             


His Met Gly Arg Lys Pro Gly Tyr Phe Ser Phe Leu Asp Pro Phe Ser 
    530                 535                 540                 


Pro Gly Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys 
545                 550                 555                 560 


Val Leu Phe Leu Val Ala Arg Leu Thr Pro Tyr Glu Trp Tyr Ser Pro 
                565                 570                 575     


His Pro Cys Ala Gln Gly Arg Cys Asn Leu Leu Val Asn Gln Tyr Ser 
            580                 585                 590         


Leu Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly 
        595                 600                 605             


Ser Thr Ile Ala Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val 
    610                 615                 620                 


Trp Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu 
625                 630                 635                 640 


Ala Ala Phe Leu Thr Val Gln Arg Met Asp Val Pro Ile Glu Ser Val 
                645                 650                 655     


Asp Asp Leu Ala Asp Gln Thr Ala Ile Glu Tyr Gly Thr Ile His Gly 
            660                 665                 670         


Gly Ser Ser Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln 
        675                 680                 685             


Arg Met Trp Asn Tyr Met Tyr Ser Lys Gln Pro Ser Val Phe Val Lys 
    690                 695                 700                 


Ser Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Asn Tyr Ala Phe 
705                 710                 715                 720 


Leu Leu Glu Ser Thr Met Asn Glu Tyr Tyr Arg Gln Arg Asn Cys Asn 
                725                 730                 735     


Leu Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly 
            740                 745                 750         


Met Pro Val Gly Ser Val Phe Arg Asp Glu Phe Asp Leu Ala Ile Leu 
        755                 760                 765             


Gln Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp 
    770                 775                 780                 


Glu Gly Gly Lys Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu 
785                 790                 795                 800 


Gly Met Glu Asn Ile Gly Gly Ile Phe Val Val Leu Ile Cys Gly Leu 
                805                 810                 815     


Ile Val Ala Ile Phe Met Ala Met Leu Glu Phe Leu Trp Thr Leu Arg 
            820                 825                 830         


His Ser Glu Ala Thr Glu Val Ser Val Cys Gln Glu Met Val Thr Glu 
        835                 840                 845             


Leu Arg Ser Ile Ile Leu Cys Gln Asp Ser Ile His Pro Arg Arg Arg 
    850                 855                 860                 


Arg Ala Ala Val Pro Pro Pro Arg Pro Pro Ile Pro Glu Glu Arg Arg 
865                 870                 875                 880 


Pro Arg Gly Thr Ala Thr Leu Ser Asn Gly Lys Leu Cys Gly Ala Gly 
                885                 890                 895     


Glu Pro Asp Gln Leu Ala Gln Arg Leu Ala Gln Glu Ala Ala Leu Val 
            900                 905                 910         


Ala Arg Gly Cys Thr His Ile Arg Val Cys Pro Glu Cys Arg Arg Phe 
        915                 920                 925             


Gln Gly Leu Arg Ala Arg Pro Ser Pro Ala Arg Ser Glu Glu Ser Leu 
    930                 935                 940                 


Glu Trp Glu Lys Thr Thr Asn Ser Ser Glu Pro Glu 
945                 950                 955     


<210>  4723
<211>  981
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIK5__Homo_sapiens__NP_001287959

<400>  4723

Met Pro Ala Glu Leu Leu Leu Leu Leu Ile Val Ala Phe Ala Ser Pro 
1               5                   10                  15      


Ser Cys Gln Val Leu Ser Ser Leu Arg Met Ala Ala Ile Leu Asp Asp 
            20                  25                  30          


Gln Thr Val Cys Gly Arg Gly Glu Arg Leu Ala Leu Ala Leu Ala Arg 
        35                  40                  45              


Glu Gln Ile Asn Gly Ile Ile Glu Val Pro Ala Lys Ala Arg Val Glu 
    50                  55                  60                  


Val Asp Ile Phe Glu Leu Gln Arg Asp Ser Gln Tyr Glu Thr Thr Asp 
65                  70                  75                  80  


Thr Met Cys Gln Ile Leu Pro Lys Gly Val Val Ser Val Leu Gly Pro 
                85                  90                  95      


Ser Ser Ser Pro Ala Ser Ala Ser Thr Val Ser His Ile Cys Gly Glu 
            100                 105                 110         


Lys Glu Ile Pro His Ile Lys Val Gly Pro Glu Glu Thr Pro Arg Leu 
        115                 120                 125             


Gln Tyr Leu Arg Phe Ala Ser Val Ser Leu Tyr Pro Ser Asn Glu Asp 
    130                 135                 140                 


Val Ser Leu Ala Val Ser Arg Ile Leu Lys Ser Phe Asn Tyr Pro Ser 
145                 150                 155                 160 


Ala Ser Leu Ile Cys Ala Lys Ala Glu Cys Leu Leu Arg Leu Glu Glu 
                165                 170                 175     


Leu Val Arg Gly Phe Leu Ile Ser Lys Glu Thr Leu Ser Val Arg Met 
            180                 185                 190         


Leu Asp Asp Ser Arg Asp Pro Thr Pro Leu Leu Lys Glu Ile Arg Asp 
        195                 200                 205             


Asp Lys Val Ser Thr Ile Ile Ile Asp Ala Asn Ala Ser Ile Ser His 
    210                 215                 220                 


Leu Ile Leu Arg Lys Ala Ser Glu Leu Gly Met Thr Ser Ala Phe Tyr 
225                 230                 235                 240 


Lys Tyr Ile Leu Thr Thr Met Asp Phe Pro Ile Leu His Leu Asp Gly 
                245                 250                 255     


Ile Val Glu Asp Ser Ser Asn Ile Leu Gly Phe Ser Met Phe Asn Thr 
            260                 265                 270         


Ser His Pro Phe Tyr Pro Glu Phe Val Arg Ser Leu Asn Met Ser Trp 
        275                 280                 285             


Arg Glu Asn Cys Glu Ala Ser Thr Tyr Leu Gly Pro Ala Leu Ser Ala 
    290                 295                 300                 


Ala Leu Met Phe Asp Ala Val His Val Val Val Ser Ala Val Arg Glu 
305                 310                 315                 320 


Leu Asn Arg Ser Gln Glu Ile Gly Val Lys Pro Leu Ala Cys Thr Ser 
                325                 330                 335     


Ala Asn Ile Trp Pro His Gly Thr Ser Leu Met Asn Tyr Leu Arg Met 
            340                 345                 350         


Val Glu Tyr Asp Gly Leu Thr Gly Arg Val Glu Phe Asn Ser Lys Gly 
        355                 360                 365             


Gln Arg Thr Asn Tyr Thr Leu Arg Ile Leu Glu Lys Ser Arg Gln Gly 
    370                 375                 380                 


His Arg Glu Ile Gly Val Trp Tyr Ser Asn Arg Thr Leu Ala Met Asn 
385                 390                 395                 400 


Ala Thr Thr Leu Asp Ile Asn Leu Ser Gln Thr Leu Ala Asn Lys Thr 
                405                 410                 415     


Leu Val Val Thr Thr Ile Leu Glu Asn Pro Tyr Val Met Arg Arg Pro 
            420                 425                 430         


Asn Phe Gln Ala Leu Ser Gly Asn Glu Arg Phe Glu Gly Phe Cys Val 
        435                 440                 445             


Asp Met Leu Arg Glu Leu Ala Glu Leu Leu Arg Phe Arg Tyr Arg Leu 
    450                 455                 460                 


Arg Leu Val Glu Asp Gly Leu Tyr Gly Ala Pro Glu Pro Asn Gly Ser 
465                 470                 475                 480 


Trp Thr Gly Met Val Gly Glu Leu Ile Asn Arg Lys Ala Asp Leu Ala 
                485                 490                 495     


Val Ala Ala Phe Thr Ile Thr Ala Glu Arg Glu Lys Val Ile Asp Phe 
            500                 505                 510         


Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Val His 
        515                 520                 525             


Met Gly Arg Lys Pro Gly Tyr Phe Ser Phe Leu Asp Pro Phe Ser Pro 
    530                 535                 540                 


Ala Val Trp Leu Phe Met Leu Leu Ala Tyr Leu Ala Val Ser Cys Val 
545                 550                 555                 560 


Leu Phe Leu Ala Ala Arg Leu Ser Pro Tyr Glu Trp Tyr Asn Pro His 
                565                 570                 575     


Pro Cys Leu Arg Ala Arg Pro His Ile Leu Glu Asn Gln Tyr Thr Leu 
            580                 585                 590         


Gly Asn Ser Leu Trp Phe Pro Val Gly Gly Phe Met Gln Gln Gly Ser 
        595                 600                 605             


Glu Ile Met Pro Arg Ala Leu Ser Thr Arg Cys Val Ser Gly Val Trp 
    610                 615                 620                 


Trp Ala Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
625                 630                 635                 640 


Ala Phe Leu Thr Val Gln Arg Met Glu Val Pro Val Glu Ser Ala Asp 
                645                 650                 655     


Asp Leu Ala Asp Gln Thr Asn Ile Glu Tyr Gly Thr Ile His Ala Gly 
            660                 665                 670         


Ser Thr Met Thr Phe Phe Gln Asn Ser Arg Tyr Gln Thr Tyr Gln Arg 
        675                 680                 685             


Met Trp Asn Tyr Met Gln Ser Lys Gln Pro Ser Val Phe Val Lys Ser 
    690                 695                 700                 


Thr Glu Glu Gly Ile Ala Arg Val Leu Asn Ser Arg Tyr Ala Phe Leu 
705                 710                 715                 720 


Leu Glu Ser Thr Met Asn Glu Tyr His Arg Arg Leu Asn Cys Asn Leu 
                725                 730                 735     


Thr Gln Ile Gly Gly Leu Leu Asp Thr Lys Gly Tyr Gly Ile Gly Met 
            740                 745                 750         


Pro Leu Gly Ser Pro Phe Arg Asp Glu Ile Thr Leu Ala Ile Leu Gln 
        755                 760                 765             


Leu Gln Glu Asn Asn Arg Leu Glu Ile Leu Lys Arg Lys Trp Trp Glu 
    770                 775                 780                 


Gly Gly Arg Cys Pro Lys Glu Glu Asp His Arg Ala Lys Gly Leu Gly 
785                 790                 795                 800 


Met Glu Asn Ile Gly Gly Ile Phe Ile Val Leu Ile Cys Gly Leu Ile 
                805                 810                 815     


Ile Ala Val Phe Val Ala Val Met Glu Phe Ile Trp Ser Thr Arg Arg 
            820                 825                 830         


Ser Ala Glu Ser Glu Glu Thr Pro Ala Leu His Pro Ala Ala Cys Gln 
        835                 840                 845             


Cys Ser Ala Leu Gly Pro Arg Thr Pro Leu Lys Glu Pro Ser Met Leu 
    850                 855                 860                 


Leu Val Lys Val Pro Ser Thr Arg Val Gln Val Ala Phe Ser Arg Thr 
865                 870                 875                 880 


Ser Leu Arg Gln Val Cys Pro Phe Leu Leu Gln His Gln Leu Ser Ser 
                885                 890                 895     


Leu Tyr Trp Ile Gln Ala Thr Asn Val Gln Ile Cys Cys His Phe Ser 
            900                 905                 910         


Ser Leu Lys Pro Ser Pro Asp Leu Thr Phe Pro Pro Ser His Arg Pro 
        915                 920                 925             


Leu Ser Ser Leu Leu Phe Thr Ala Leu Ala Ala Val Gly Gly Leu Pro 
    930                 935                 940                 


Asp Ala Ser Ser Phe Phe Phe Pro Pro Ile Ser Ser Cys Pro Pro Leu 
945                 950                 955                 960 


Gln Ser Gly Ile Gly Pro Cys His Ser Thr Glu Ala Thr Leu Val Thr 
                965                 970                 975     


Ser Asn Phe His Val 
            980     


<210>  4724
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIN1__Homo_sapiens__NP_000823

<400>  4724

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Gln 
    850                 855                 860                 


Tyr His Pro Thr Asp Ile Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser 
865                 870                 875                 880 


Val Ser Thr Val Val 
                885 


<210>  4725
<211>  1464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIN2A__Homo_sapiens__NP_000824

<400>  4725

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210>  4726
<211>  1484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIN2B__Homo_sapiens__XP_011518932

<400>  4726

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 


Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 


Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     


Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         


Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             


Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 


Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 


Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     


Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         


Ser Ile Gly Ser Ala Ser Ser Ile  Asp Gly Leu Tyr Asp  Cys Asp Asn 
        995                 1000                 1005             


Pro Pro  Phe Thr Thr Gln Ser  Arg Ser Ile Ser Lys  Lys Pro Leu 
    1010                 1015                 1020             


Asp Ile  Gly Leu Pro Ser Ser  Lys His Ser Gln Leu  Ser Asp Leu 
    1025                 1030                 1035             


Tyr Gly  Lys Phe Ser Phe Lys  Ser Asp Arg Tyr Ser  Gly His Asp 
    1040                 1045                 1050             


Asp Leu  Ile Arg Ser Asp Val  Ser Asp Ile Ser Thr  His Thr Val 
    1055                 1060                 1065             


Thr Tyr  Gly Asn Ile Glu Gly  Asn Ala Ala Lys Arg  Arg Lys Gln 
    1070                 1075                 1080             


Gln Tyr  Lys Asp Ser Leu Lys  Lys Arg Pro Ala Ser  Ala Lys Ser 
    1085                 1090                 1095             


Arg Arg  Glu Phe Asp Glu Ile  Glu Leu Ala Tyr Arg  Arg Arg Pro 
    1100                 1105                 1110             


Pro Arg  Ser Pro Asp His Lys  Arg Tyr Phe Arg Asp  Lys Glu Gly 
    1115                 1120                 1125             


Leu Arg  Asp Phe Tyr Leu Asp  Gln Phe Arg Thr Lys  Glu Asn Ser 
    1130                 1135                 1140             


Pro His  Trp Glu His Val Asp  Leu Thr Asp Ile Tyr  Lys Glu Arg 
    1145                 1150                 1155             


Ser Asp  Asp Phe Lys Arg Asp  Ser Val Ser Gly Gly  Gly Pro Cys 
    1160                 1165                 1170             


Thr Asn  Arg Ser His Ile Lys  His Gly Thr Gly Asp  Lys His Gly 
    1175                 1180                 1185             


Val Val  Ser Gly Val Pro Ala  Pro Trp Glu Lys Asn  Leu Thr Asn 
    1190                 1195                 1200             


Val Glu  Trp Glu Asp Arg Ser  Gly Gly Asn Phe Cys  Arg Ser Cys 
    1205                 1210                 1215             


Pro Ser  Lys Leu His Asn Tyr  Ser Thr Thr Val Thr  Gly Gln Asn 
    1220                 1225                 1230             


Ser Gly  Arg Gln Ala Cys Ile  Arg Cys Glu Ala Cys  Lys Lys Ala 
    1235                 1240                 1245             


Gly Asn  Leu Tyr Asp Ile Ser  Glu Asp Asn Ser Leu  Gln Glu Leu 
    1250                 1255                 1260             


Asp Gln  Pro Ala Ala Pro Val  Ala Val Thr Ser Asn  Ala Ser Thr 
    1265                 1270                 1275             


Thr Lys  Tyr Pro Gln Ser Pro  Thr Asn Ser Lys Ala  Gln Lys Lys 
    1280                 1285                 1290             


Asn Arg  Asn Lys Leu Arg Arg  Gln His Ser Tyr Asp  Thr Phe Val 
    1295                 1300                 1305             


Asp Leu  Gln Lys Glu Glu Ala  Ala Leu Ala Pro Arg  Ser Val Ser 
    1310                 1315                 1320             


Leu Lys  Asp Lys Gly Arg Phe  Met Asp Gly Ser Pro  Tyr Ala His 
    1325                 1330                 1335             


Met Phe  Glu Met Ser Ala Gly  Glu Ser Thr Phe Ala  Asn Asn Lys 
    1340                 1345                 1350             


Ser Ser  Val Pro Thr Ala Gly  His His His His Asn  Asn Pro Gly 
    1355                 1360                 1365             


Gly Gly  Tyr Met Leu Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr 
    1370                 1375                 1380             


Gln Asn  Pro Phe Ile Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu 
    1385                 1390                 1395             


His Gly  Ser Lys Ser Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly 
    1400                 1405                 1410             


Ala Ser  Lys Ala Arg Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys 
    1415                 1420                 1425             


Pro Val  Val Ser Ala Leu His  Gly Ala Val Pro Ala  Arg Phe Gln 
    1430                 1435                 1440             


Lys Asp  Ile Cys Ile Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn 
    1445                 1450                 1455             


Asn Lys  Asn Pro Arg Ala Phe  Asn Gly Ser Ser Asn  Gly His Val 
    1460                 1465                 1470             


Tyr Glu  Lys Leu Ser Ser Ile  Glu Ser Asp Val 
    1475                 1480                 


<210>  4727
<211>  1233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIN2C__Homo_sapiens__NP_000826

<400>  4727

Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      


Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          


Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              


Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  


Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  


Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      


Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         


Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             


Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 


Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 


Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     


Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         


Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             


Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 


Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 


Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     


Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         


Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             


Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 


Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 


Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     


Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         


Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             


Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 


Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 


Arg His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val 
                405                 410                 415     


Glu Ser Pro Asp Pro Gly Thr Gly Gly Cys Val Pro Asn Thr Val Pro 
            420                 425                 430         


Cys Arg Arg Gln Ser Asn His Thr Phe Ser Ser Gly Asp Val Ala Pro 
        435                 440                 445             


Tyr Thr Lys Leu Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys 
    450                 455                 460                 


Leu Ala Arg Val Val Lys Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn 
465                 470                 475                 480 


Gly Lys His Gly Lys Arg Val Arg Gly Val Trp Asn Gly Met Ile Gly 
                485                 490                 495     


Glu Val Tyr Tyr Lys Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile 
            500                 505                 510         


Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu 
        515                 520                 525             


Thr Gly Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro 
    530                 535                 540                 


Ser Ala Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe 
545                 550                 555                 560 


Val Met Cys Leu Thr Val Val Ala Ile Thr Val Phe Met Phe Glu Tyr 
                565                 570                 575     


Phe Ser Pro Val Ser Tyr Asn Gln Asn Leu Thr Arg Gly Lys Lys Ser 
            580                 585                 590         


Gly Gly Pro Ala Phe Thr Ile Gly Lys Ser Val Trp Leu Leu Trp Ala 
        595                 600                 605             


Leu Val Phe Asn Asn Ser Val Pro Ile Glu Asn Pro Arg Gly Thr Thr 
    610                 615                 620                 


Ser Lys Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu 
625                 630                 635                 640 


Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Gln Tyr 
                645                 650                 655     


Ile Asp Thr Val Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Gln 
            660                 665                 670         


Asp Gln Tyr Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr 
        675                 680                 685             


Glu Arg Asn Ile Arg Ser Asn Tyr Arg Asp Met His Thr His Met Val 
    690                 695                 700                 


Lys Phe Asn Gln Arg Ser Val Glu Asp Ala Leu Thr Ser Leu Lys Met 
705                 710                 715                 720 


Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met 
                725                 730                 735     


Ala Gly Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys 
            740                 745                 750         


Val Phe Ala Thr Thr Gly Tyr Gly Ile Ala Met Gln Lys Asp Ser His 
        755                 760                 765             


Trp Lys Arg Ala Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Gly 
    770                 775                 780                 


Glu Thr Gln Lys Leu Glu Thr Val Trp Leu Ser Gly Ile Cys Gln Asn 
785                 790                 795                 800 


Glu Lys Asn Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala 
                805                 810                 815     


Gly Val Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ala Leu Leu Val 
            820                 825                 830         


Phe Ala Trp Glu His Leu Val Tyr Trp Lys Leu Arg His Ser Val Pro 
        835                 840                 845             


Asn Ser Ser Gln Leu Asp Phe Leu Leu Ala Phe Ser Arg Gly Ile Tyr 
    850                 855                 860                 


Ser Cys Phe Ser Gly Val Gln Ser Leu Ala Ser Pro Pro Arg Gln Ala 
865                 870                 875                 880 


Ser Pro Asp Leu Thr Ala Ser Ser Ala Gln Ala Ser Val Leu Lys Met 
                885                 890                 895     


Leu Gln Ala Ala Arg Asp Met Val Thr Thr Ala Gly Val Ser Ser Ser 
            900                 905                 910         


Leu Asp Arg Ala Thr Arg Thr Ile Glu Asn Trp Gly Gly Gly Arg Arg 
        915                 920                 925             


Ala Pro Pro Pro Ser Pro Cys Pro Thr Pro Arg Ser Gly Pro Ser Pro 
    930                 935                 940                 


Cys Leu Pro Thr Pro Asp Pro Pro Pro Glu Pro Ser Pro Thr Gly Trp 
945                 950                 955                 960 


Gly Pro Pro Asp Gly Gly Arg Ala Ala Leu Val Arg Arg Ala Pro Gln 
                965                 970                 975     


Pro Pro Gly Arg Pro Pro Thr Pro Gly Pro Pro Leu Ser Asp Val Ser 
            980                 985                 990         


Arg Val Ser Arg Arg Pro Ala Trp  Glu Ala Arg Trp Pro  Val Arg Thr 
        995                 1000                 1005             


Gly His  Cys Gly Arg His Leu  Ser Ala Ser Glu Arg  Pro Leu Ser 
    1010                 1015                 1020             


Pro Ala  Arg Cys His Tyr Ser  Ser Phe Pro Arg Ala  Asp Arg Ser 
    1025                 1030                 1035             


Gly Arg  Pro Phe Leu Pro Leu  Phe Pro Glu Leu Glu  Asp Leu Pro 
    1040                 1045                 1050             


Leu Leu  Gly Pro Glu Gln Leu  Ala Arg Arg Glu Ala  Leu Leu His 
    1055                 1060                 1065             


Ala Ala  Trp Ala Arg Gly Ser  Arg Pro Arg His Ala  Ser Leu Pro 
    1070                 1075                 1080             


Ser Ser  Val Ala Glu Ala Phe  Ala Arg Pro Ser Ser  Leu Pro Ala 
    1085                 1090                 1095             


Gly Cys  Thr Gly Pro Ala Cys  Ala Arg Pro Asp Gly  His Ser Ala 
    1100                 1105                 1110             


Cys Arg  Arg Leu Ala Gln Ala  Gln Ser Met Cys Leu  Pro Ile Tyr 
    1115                 1120                 1125             


Arg Glu  Ala Cys Gln Glu Gly  Glu Gln Ala Gly Ala  Pro Ala Trp 
    1130                 1135                 1140             


Gln His  Arg Gln His Val Cys  Leu His Ala His Ala  His Leu Pro 
    1145                 1150                 1155             


Phe Cys  Trp Gly Ala Val Cys  Pro His Leu Pro Pro  Cys Ala Ser 
    1160                 1165                 1170             


His Gly  Ser Trp Leu Ser Gly  Ala Trp Gly Pro Leu  Gly His Arg 
    1175                 1180                 1185             


Gly Arg  Thr Leu Gly Leu Gly  Thr Gly Tyr Arg Asp  Ser Gly Gly 
    1190                 1195                 1200             


Leu Asp  Glu Ile Ser Arg Val  Ala Arg Gly Thr Gln  Gly Phe Pro 
    1205                 1210                 1215             


Gly Pro  Cys Thr Trp Arg Arg  Ile Ser Ser Leu Glu  Ser Glu Val 
    1220                 1225                 1230             


<210>  4728
<211>  1336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIN2D__Homo_sapiens__NP_000827

<400>  4728

Met Arg Gly Ala Gly Gly Pro Arg Gly Pro Arg Gly Pro Ala Lys Met 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Cys Ala Ser Pro Phe Pro Glu Glu Ala 
            20                  25                  30          


Pro Gly Pro Gly Gly Ala Gly Gly Pro Gly Gly Gly Leu Gly Gly Ala 
        35                  40                  45              


Arg Pro Leu Asn Val Ala Leu Val Phe Ser Gly Pro Ala Tyr Ala Ala 
    50                  55                  60                  


Glu Ala Ala Arg Leu Gly Pro Ala Val Ala Ala Ala Val Arg Ser Pro 
65                  70                  75                  80  


Gly Leu Asp Val Arg Pro Val Ala Leu Val Leu Asn Gly Ser Asp Pro 
                85                  90                  95      


Arg Ser Leu Val Leu Gln Leu Cys Asp Leu Leu Ser Gly Leu Arg Val 
            100                 105                 110         


His Gly Val Val Phe Glu Asp Asp Ser Arg Ala Pro Ala Val Ala Pro 
        115                 120                 125             


Ile Leu Asp Phe Leu Ser Ala Gln Thr Ser Leu Pro Ile Val Ala Val 
    130                 135                 140                 


His Gly Gly Ala Ala Leu Val Leu Thr Pro Lys Glu Lys Gly Ser Thr 
145                 150                 155                 160 


Phe Leu Gln Leu Gly Ser Ser Thr Glu Gln Gln Leu Gln Val Ile Phe 
                165                 170                 175     


Glu Val Leu Glu Glu Tyr Asp Trp Thr Ser Phe Val Ala Val Thr Thr 
            180                 185                 190         


Arg Ala Pro Gly His Arg Ala Phe Leu Ser Tyr Ile Glu Val Leu Thr 
        195                 200                 205             


Asp Gly Ser Leu Val Gly Trp Glu His Arg Gly Ala Leu Thr Leu Asp 
    210                 215                 220                 


Pro Gly Ala Gly Glu Ala Val Leu Ser Ala Gln Leu Arg Ser Val Ser 
225                 230                 235                 240 


Ala Gln Ile Arg Leu Leu Phe Cys Ala Arg Glu Glu Ala Glu Pro Val 
                245                 250                 255     


Phe Arg Ala Ala Glu Glu Ala Gly Leu Thr Gly Ser Gly Tyr Val Trp 
            260                 265                 270         


Phe Met Val Gly Pro Gln Leu Ala Gly Gly Gly Gly Ser Gly Ala Pro 
        275                 280                 285             


Gly Glu Pro Pro Leu Leu Pro Gly Gly Ala Pro Leu Pro Ala Gly Leu 
    290                 295                 300                 


Phe Ala Val Arg Ser Ala Gly Trp Arg Asp Asp Leu Ala Arg Arg Val 
305                 310                 315                 320 


Ala Ala Gly Val Ala Val Val Ala Arg Gly Ala Gln Ala Leu Leu Arg 
                325                 330                 335     


Asp Tyr Gly Phe Leu Pro Glu Leu Gly His Asp Cys Arg Ala Gln Asn 
            340                 345                 350         


Arg Thr His Arg Gly Glu Ser Leu His Arg Tyr Phe Met Asn Ile Thr 
        355                 360                 365             


Trp Asp Asn Arg Asp Tyr Ser Phe Asn Glu Asp Gly Phe Leu Val Asn 
    370                 375                 380                 


Pro Ser Leu Val Val Ile Ser Leu Thr Arg Asp Arg Thr Trp Glu Val 
385                 390                 395                 400 


Val Gly Ser Trp Glu Gln Gln Thr Leu Arg Leu Lys Tyr Pro Leu Trp 
                405                 410                 415     


Ser Arg Tyr Gly Arg Phe Leu Gln Pro Val Asp Asp Thr Gln His Leu 
            420                 425                 430         


Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val Glu Pro Ala 
        435                 440                 445             


Asp Pro Ile Ser Gly Thr Cys Ile Arg Asp Ser Val Pro Cys Arg Ser 
    450                 455                 460                 


Gln Leu Asn Arg Thr His Ser Pro Pro Pro Asp Ala Pro Arg Pro Glu 
465                 470                 475                 480 


Lys Arg Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Arg Leu Ala 
                485                 490                 495     


His Thr Ile Gly Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn Gly Lys 
            500                 505                 510         


His Gly Lys Lys Ile Asp Gly Val Trp Asn Gly Met Ile Gly Glu Val 
        515                 520                 525             


Phe Tyr Gln Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile Asn Glu 
    530                 535                 540                 


Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu Thr Gly 
545                 550                 555                 560 


Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro Ser Ala 
                565                 570                 575     


Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe Val Met 
            580                 585                 590         


Cys Leu Thr Val Val Ala Val Thr Val Phe Ile Phe Glu Tyr Leu Ser 
        595                 600                 605             


Pro Val Gly Tyr Asn Arg Ser Leu Ala Thr Gly Lys Arg Pro Gly Gly 
    610                 615                 620                 


Ser Thr Phe Thr Ile Gly Lys Ser Ile Trp Leu Leu Trp Ala Leu Val 
625                 630                 635                 640 


Phe Asn Asn Ser Val Pro Val Glu Asn Pro Arg Gly Thr Thr Ser Lys 
                645                 650                 655     


Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu Ala Ser 
            660                 665                 670         


Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Glu Tyr Val Asp 
        675                 680                 685             


Thr Val Ser Gly Leu Ser Asp Arg Lys Phe Gln Arg Pro Gln Glu Gln 
    690                 695                 700                 


Tyr Pro Pro Leu Lys Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Lys 
705                 710                 715                 720 


Asn Ile Arg Ser Asn Tyr Pro Asp Met His Ser Tyr Met Val Arg Tyr 
                725                 730                 735     


Asn Gln Pro Arg Val Glu Glu Ala Leu Thr Gln Leu Lys Ala Gly Lys 
            740                 745                 750         


Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Arg 
        755                 760                 765             


Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe 
    770                 775                 780                 


Ala Thr Thr Gly Tyr Gly Ile Ala Leu His Lys Gly Ser Arg Trp Lys 
785                 790                 795                 800 


Arg Pro Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Asp Glu Ile 
                805                 810                 815     


Glu Met Leu Glu Arg Leu Trp Leu Ser Gly Ile Cys His Asn Asp Lys 
            820                 825                 830         


Ile Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala Gly Val 
        835                 840                 845             


Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ser Leu Leu Val Phe Ala 
    850                 855                 860                 


Trp Glu His Leu Val Tyr Trp Arg Leu Arg His Cys Leu Gly Pro Thr 
865                 870                 875                 880 


His Arg Met Asp Phe Leu Leu Ala Phe Ser Arg Gly Met Tyr Ser Cys 
                885                 890                 895     


Cys Ser Ala Glu Ala Ala Pro Pro Pro Ala Lys Pro Pro Pro Pro Pro 
            900                 905                 910         


Gln Pro Leu Pro Ser Pro Ala Tyr Pro Ala Pro Arg Pro Ala Pro Gly 
        915                 920                 925             


Pro Ala Pro Phe Val Pro Arg Glu Arg Ala Ser Val Asp Arg Trp Arg 
    930                 935                 940                 


Arg Thr Lys Gly Ala Gly Pro Pro Gly Gly Ala Gly Leu Ala Asp Gly 
945                 950                 955                 960 


Phe His Arg Tyr Tyr Gly Pro Ile Glu Pro Gln Gly Leu Gly Leu Gly 
                965                 970                 975     


Leu Gly Glu Ala Arg Ala Ala Pro Arg Gly Ala Ala Gly Arg Pro Leu 
            980                 985                 990         


Ser Pro Pro Ala Ala Gln Pro Pro  Gln Lys Pro Pro Pro  Ser Tyr Phe 
        995                 1000                 1005             


Ala Ile  Val Arg Asp Lys Glu  Pro Ala Glu Pro Pro  Ala Gly Ala 
    1010                 1015                 1020             


Phe Pro  Gly Phe Pro Ser Pro  Pro Ala Pro Pro Ala  Ala Ala Ala 
    1025                 1030                 1035             


Thr Ala  Val Gly Pro Pro Leu  Cys Arg Leu Ala Phe  Glu Asp Glu 
    1040                 1045                 1050             


Ser Pro  Pro Ala Pro Ala Arg  Trp Pro Arg Ser Asp  Pro Glu Ser 
    1055                 1060                 1065             


Gln Pro  Leu Leu Gly Pro Gly  Ala Gly Gly Ala Gly  Gly Thr Gly 
    1070                 1075                 1080             


Gly Ala  Gly Gly Gly Ala Pro  Ala Ala Pro Pro Pro  Cys Arg Ala 
    1085                 1090                 1095             


Ala Pro  Pro Pro Cys Pro Tyr  Leu Asp Leu Glu Pro  Ser Pro Ser 
    1100                 1105                 1110             


Asp Ser  Glu Asp Ser Glu Ser  Leu Gly Gly Ala Ser  Leu Gly Gly 
    1115                 1120                 1125             


Leu Glu  Pro Trp Trp Phe Ala  Asp Phe Pro Tyr Pro  Tyr Ala Glu 
    1130                 1135                 1140             


Arg Leu  Gly Pro Pro Pro Gly  Arg Tyr Trp Ser Val  Asp Lys Leu 
    1145                 1150                 1155             


Gly Gly  Trp Arg Ala Gly Ser  Trp Asp Tyr Leu Pro  Pro Arg Ser 
    1160                 1165                 1170             


Gly Pro  Ala Ala Trp His Cys  Arg His Cys Ala Ser  Leu Glu Leu 
    1175                 1180                 1185             


Leu Pro  Pro Pro Arg His Leu  Ser Cys Ser His Asp  Gly Leu Asp 
    1190                 1195                 1200             


Gly Gly  Trp Trp Ala Pro Pro  Pro Pro Pro Trp Ala  Ala Gly Pro 
    1205                 1210                 1215             


Leu Pro  Arg Arg Arg Ala Arg  Cys Gly Cys Pro Arg  Ser His Pro 
    1220                 1225                 1230             


His Arg  Pro Arg Ala Ser His  Arg Thr Pro Ala Ala  Ala Ala Pro 
    1235                 1240                 1245             


His His  His Arg His Arg Arg  Ala Ala Gly Gly Trp  Asp Leu Pro 
    1250                 1255                 1260             


Pro Pro  Ala Pro Thr Ser Arg  Ser Leu Glu Asp Leu  Ser Ser Cys 
    1265                 1270                 1275             


Pro Arg  Ala Ala Pro Ala Arg  Arg Leu Thr Gly Pro  Ser Arg His 
    1280                 1285                 1290             


Ala Arg  Arg Cys Pro His Ala  Ala His Trp Gly Pro  Pro Leu Pro 
    1295                 1300                 1305             


Thr Ala  Ser His Arg Arg His  Arg Gly Gly Asp Leu  Gly Thr Arg 
    1310                 1315                 1320             


Arg Gly  Ser Ala His Phe Ser  Ser Leu Glu Ser Glu  Val 
    1325                 1330                 1335     


<210>  4729
<211>  1115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIN3A__Homo_sapiens__NP_597702

<400>  4729

Met Arg Arg Leu Ser Leu Trp Trp Leu Leu Ser Arg Val Cys Leu Leu 
1               5                   10                  15      


Leu Pro Pro Pro Cys Ala Leu Val Leu Ala Gly Val Pro Ser Ser Ser 
            20                  25                  30          


Ser His Pro Gln Pro Cys Gln Ile Leu Lys Arg Ile Gly His Ala Val 
        35                  40                  45              


Arg Val Gly Ala Val His Leu Gln Pro Trp Thr Thr Ala Pro Arg Ala 
    50                  55                  60                  


Ala Ser Arg Ala Pro Asp Asp Ser Arg Ala Gly Ala Gln Arg Asp Glu 
65                  70                  75                  80  


Pro Glu Pro Gly Thr Arg Arg Ser Pro Ala Pro Ser Pro Gly Ala Arg 
                85                  90                  95      


Trp Leu Gly Ser Thr Leu His Gly Arg Gly Pro Pro Gly Ser Arg Lys 
            100                 105                 110         


Pro Gly Glu Gly Ala Arg Ala Glu Ala Leu Trp Pro Arg Asp Ala Leu 
        115                 120                 125             


Leu Phe Ala Val Asp Asn Leu Asn Arg Val Glu Gly Leu Leu Pro Tyr 
    130                 135                 140                 


Asn Leu Ser Leu Glu Val Val Met Ala Ile Glu Ala Gly Leu Gly Asp 
145                 150                 155                 160 


Leu Pro Leu Leu Pro Phe Ser Ser Pro Ser Ser Pro Trp Ser Ser Asp 
                165                 170                 175     


Pro Phe Ser Phe Leu Gln Ser Val Cys His Thr Val Val Val Gln Gly 
            180                 185                 190         


Val Ser Ala Leu Leu Ala Phe Pro Gln Ser Gln Gly Glu Met Met Glu 
        195                 200                 205             


Leu Asp Leu Val Ser Leu Val Leu His Ile Pro Val Ile Ser Ile Val 
    210                 215                 220                 


Arg His Glu Phe Pro Arg Glu Ser Gln Asn Pro Leu His Leu Gln Leu 
225                 230                 235                 240 


Ser Leu Glu Asn Ser Leu Ser Ser Asp Ala Asp Val Thr Val Ser Ile 
                245                 250                 255     


Leu Thr Met Asn Asn Trp Tyr Asn Phe Ser Leu Leu Leu Cys Gln Glu 
            260                 265                 270         


Asp Trp Asn Ile Thr Asp Phe Leu Leu Leu Thr Gln Asn Asn Ser Lys 
        275                 280                 285             


Phe His Leu Gly Ser Ile Ile Asn Ile Thr Ala Asn Leu Pro Ser Thr 
    290                 295                 300                 


Gln Asp Leu Leu Ser Phe Leu Gln Ile Gln Leu Glu Ser Ile Lys Asn 
305                 310                 315                 320 


Ser Thr Pro Thr Val Val Met Phe Gly Cys Asp Met Glu Ser Ile Arg 
                325                 330                 335     


Arg Ile Phe Glu Ile Thr Thr Gln Phe Gly Val Met Pro Pro Glu Leu 
            340                 345                 350         


Arg Trp Val Leu Gly Asp Ser Gln Asn Val Glu Glu Leu Arg Thr Glu 
        355                 360                 365             


Gly Leu Pro Leu Gly Leu Ile Ala His Gly Lys Thr Thr Gln Ser Val 
    370                 375                 380                 


Phe Glu His Tyr Val Gln Asp Ala Met Glu Leu Val Ala Arg Ala Val 
385                 390                 395                 400 


Ala Thr Ala Thr Met Ile Gln Pro Glu Leu Ala Leu Ile Pro Ser Thr 
                405                 410                 415     


Met Asn Cys Met Glu Val Glu Thr Thr Asn Leu Thr Ser Gly Gln Tyr 
            420                 425                 430         


Leu Ser Arg Phe Leu Ala Asn Thr Thr Phe Arg Gly Leu Ser Gly Ser 
        435                 440                 445             


Ile Arg Val Lys Gly Ser Thr Ile Val Ser Ser Glu Asn Asn Phe Phe 
    450                 455                 460                 


Ile Trp Asn Leu Gln His Asp Pro Met Gly Lys Pro Met Trp Thr Arg 
465                 470                 475                 480 


Leu Gly Ser Trp Gln Gly Gly Lys Ile Val Met Asp Tyr Gly Ile Trp 
                485                 490                 495     


Pro Glu Gln Ala Gln Arg His Lys Thr His Phe Gln His Pro Ser Lys 
            500                 505                 510         


Leu His Leu Arg Val Val Thr Leu Ile Glu His Pro Phe Val Phe Thr 
        515                 520                 525             


Arg Glu Val Asp Asp Glu Gly Leu Cys Pro Ala Gly Gln Leu Cys Leu 
    530                 535                 540                 


Asp Pro Met Thr Asn Asp Ser Ser Thr Leu Asp Ser Leu Phe Ser Ser 
545                 550                 555                 560 


Leu His Ser Ser Asn Asp Thr Val Pro Ile Lys Phe Lys Lys Cys Cys 
                565                 570                 575     


Tyr Gly Tyr Cys Ile Asp Leu Leu Glu Lys Ile Ala Glu Asp Met Asn 
            580                 585                 590         


Phe Asp Phe Asp Leu Tyr Ile Val Gly Asp Gly Lys Tyr Gly Ala Trp 
        595                 600                 605             


Lys Asn Gly His Trp Thr Gly Leu Val Gly Asp Leu Leu Arg Gly Thr 
    610                 615                 620                 


Ala His Met Ala Val Thr Ser Phe Ser Ile Asn Thr Ala Arg Ser Gln 
625                 630                 635                 640 


Val Ile Asp Phe Thr Ser Pro Phe Phe Ser Thr Ser Leu Gly Ile Leu 
                645                 650                 655     


Val Arg Thr Arg Asp Thr Ala Ala Pro Ile Gly Ala Phe Met Trp Pro 
            660                 665                 670         


Leu His Trp Thr Met Trp Leu Gly Ile Phe Val Ala Leu His Ile Thr 
        675                 680                 685             


Ala Val Phe Leu Thr Leu Tyr Glu Trp Lys Ser Pro Phe Gly Leu Thr 
    690                 695                 700                 


Pro Lys Gly Arg Asn Arg Ser Lys Val Phe Ser Phe Ser Ser Ala Leu 
705                 710                 715                 720 


Asn Ile Cys Tyr Ala Leu Leu Phe Gly Arg Thr Val Ala Ile Lys Pro 
                725                 730                 735     


Pro Lys Cys Trp Thr Gly Arg Phe Leu Met Asn Leu Trp Ala Ile Phe 
            740                 745                 750         


Cys Met Phe Cys Leu Ser Thr Tyr Thr Ala Asn Leu Ala Ala Val Met 
        755                 760                 765             


Val Gly Glu Lys Ile Tyr Glu Glu Leu Ser Gly Ile His Asp Pro Lys 
    770                 775                 780                 


Leu His His Pro Ser Gln Gly Phe Arg Phe Gly Thr Val Arg Glu Ser 
785                 790                 795                 800 


Ser Ala Glu Asp Tyr Val Arg Gln Ser Phe Pro Glu Met His Glu Tyr 
                805                 810                 815     


Met Arg Arg Tyr Asn Val Pro Ala Thr Pro Asp Gly Val Glu Tyr Leu 
            820                 825                 830         


Lys Asn Asp Pro Glu Lys Leu Asp Ala Phe Ile Met Asp Lys Ala Leu 
        835                 840                 845             


Leu Asp Tyr Glu Val Ser Ile Asp Ala Asp Cys Lys Leu Leu Thr Val 
    850                 855                 860                 


Gly Lys Pro Phe Ala Ile Glu Gly Tyr Gly Ile Gly Leu Pro Pro Asn 
865                 870                 875                 880 


Ser Pro Leu Thr Ala Asn Ile Ser Glu Leu Ile Ser Gln Tyr Lys Ser 
                885                 890                 895     


His Gly Phe Met Asp Met Leu His Asp Lys Trp Tyr Arg Val Val Pro 
            900                 905                 910         


Cys Gly Lys Arg Ser Phe Ala Val Thr Glu Thr Leu Gln Met Gly Ile 
        915                 920                 925             


Lys His Phe Ser Gly Leu Phe Val Leu Leu Cys Ile Gly Phe Gly Leu 
    930                 935                 940                 


Ser Ile Leu Thr Thr Ile Gly Glu His Ile Val Tyr Arg Leu Leu Leu 
945                 950                 955                 960 


Pro Arg Ile Lys Asn Lys Ser Lys Leu Gln Tyr Trp Leu His Thr Ser 
                965                 970                 975     


Gln Arg Leu His Arg Ala Ile Asn Thr Ser Phe Ile Glu Glu Lys Gln 
            980                 985                 990         


Gln His Phe Lys Thr Lys Arg Val  Glu Lys Arg Ser Asn  Val Gly Pro 
        995                 1000                 1005             


Arg Gln  Leu Thr Val Trp Asn  Thr Ser Asn Leu Ser  His Asp Asn 
    1010                 1015                 1020             


Arg Arg  Lys Tyr Ile Phe Ser  Asp Glu Glu Gly Gln  Asn Gln Leu 
    1025                 1030                 1035             


Gly Ile  Arg Ile His Gln Asp  Ile Pro Leu Pro Pro  Arg Arg Arg 
    1040                 1045                 1050             


Glu Leu  Pro Ala Leu Arg Thr  Thr Asn Gly Lys Ala  Asp Ser Leu 
    1055                 1060                 1065             


Asn Val  Ser Arg Asn Ser Val  Met Gln Glu Leu Ser  Glu Leu Glu 
    1070                 1075                 1080             


Lys Gln  Ile Gln Val Ile Arg  Gln Glu Leu Gln Leu  Ala Val Ser 
    1085                 1090                 1095             


Arg Lys  Thr Glu Leu Glu Glu  Tyr Gln Arg Thr Ser  Arg Thr Cys 
    1100                 1105                 1110             


Glu Ser  
    1115 


<210>  4730
<211>  1043
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIN3B__Homo_sapiens__NP_619635

<400>  4730

Met Glu Phe Val Arg Ala Leu Trp Leu Gly Leu Ala Leu Ala Leu Gly 
1               5                   10                  15      


Pro Gly Ser Ala Gly Gly His Pro Gln Pro Cys Gly Val Leu Ala Arg 
            20                  25                  30          


Leu Gly Gly Ser Val Arg Leu Gly Ala Leu Leu Pro Arg Ala Pro Leu 
        35                  40                  45              


Ala Arg Ala Arg Ala Arg Ala Ala Leu Ala Arg Ala Ala Leu Ala Pro 
    50                  55                  60                  


Arg Leu Pro His Asn Leu Ser Leu Glu Leu Val Val Ala Ala Pro Pro 
65                  70                  75                  80  


Ala Arg Asp Pro Ala Ser Leu Thr Arg Gly Leu Cys Gln Ala Leu Val 
                85                  90                  95      


Pro Pro Gly Val Ala Ala Leu Leu Ala Phe Pro Glu Ala Arg Pro Glu 
            100                 105                 110         


Leu Leu Gln Leu His Phe Leu Ala Ala Ala Thr Glu Thr Pro Val Leu 
        115                 120                 125             


Ser Leu Leu Arg Arg Glu Ala Arg Ala Pro Leu Gly Ala Pro Asn Pro 
    130                 135                 140                 


Phe His Leu Gln Leu His Trp Ala Ser Pro Leu Glu Thr Leu Leu Asp 
145                 150                 155                 160 


Val Leu Val Ala Val Leu Gln Ala His Ala Trp Glu Asp Val Gly Leu 
                165                 170                 175     


Ala Leu Cys Arg Thr Gln Asp Pro Gly Gly Leu Val Ala Leu Trp Thr 
            180                 185                 190         


Ser Arg Ala Gly Arg Pro Pro Gln Leu Val Leu Asp Leu Ser Arg Arg 
        195                 200                 205             


Asp Thr Gly Asp Ala Gly Leu Arg Ala Arg Leu Ala Pro Met Ala Ala 
    210                 215                 220                 


Pro Val Gly Gly Glu Ala Pro Val Pro Ala Ala Val Leu Leu Gly Cys 
225                 230                 235                 240 


Asp Ile Ala Arg Ala Arg Arg Val Leu Glu Ala Val Pro Pro Gly Pro 
                245                 250                 255     


His Trp Leu Leu Gly Thr Pro Leu Pro Pro Lys Ala Leu Pro Thr Ala 
            260                 265                 270         


Gly Leu Pro Pro Gly Leu Leu Ala Leu Gly Glu Val Ala Arg Pro Pro 
        275                 280                 285             


Leu Glu Ala Ala Ile His Asp Ile Val Gln Leu Val Ala Arg Ala Leu 
    290                 295                 300                 


Gly Ser Ala Ala Gln Val Gln Pro Lys Arg Ala Leu Leu Pro Ala Pro 
305                 310                 315                 320 


Val Asn Cys Gly Asp Leu Gln Pro Ala Gly Pro Glu Ser Pro Gly Arg 
                325                 330                 335     


Phe Leu Ala Arg Phe Leu Ala Asn Thr Ser Phe Gln Gly Arg Thr Gly 
            340                 345                 350         


Pro Val Trp Val Thr Gly Ser Ser Gln Val His Met Ser Arg His Phe 
        355                 360                 365             


Lys Val Trp Ser Leu Arg Arg Asp Pro Arg Gly Ala Pro Ala Trp Ala 
    370                 375                 380                 


Thr Val Gly Ser Trp Arg Asp Gly Gln Leu Asp Leu Glu Pro Gly Gly 
385                 390                 395                 400 


Ala Ser Ala Arg Pro Pro Pro Pro Gln Gly Ala Gln Val Trp Pro Lys 
                405                 410                 415     


Leu Arg Val Val Thr Leu Leu Glu His Pro Phe Val Phe Ala Arg Asp 
            420                 425                 430         


Pro Asp Glu Asp Gly Gln Cys Pro Ala Gly Gln Leu Cys Leu Asp Pro 
        435                 440                 445             


Gly Thr Asn Asp Ser Ala Thr Leu Asp Ala Leu Phe Ala Ala Leu Ala 
    450                 455                 460                 


Asn Gly Ser Ala Pro Arg Ala Leu Arg Lys Cys Cys Tyr Gly Tyr Cys 
465                 470                 475                 480 


Ile Asp Leu Leu Glu Arg Leu Ala Glu Asp Thr Pro Phe Asp Phe Glu 
                485                 490                 495     


Leu Tyr Leu Val Gly Asp Gly Lys Tyr Gly Ala Leu Arg Asp Gly Arg 
            500                 505                 510         


Trp Thr Gly Leu Val Gly Asp Leu Leu Ala Gly Arg Ala His Met Ala 
        515                 520                 525             


Val Thr Ser Phe Ser Ile Asn Ser Ala Arg Ser Gln Val Val Asp Phe 
    530                 535                 540                 


Thr Ser Pro Phe Phe Ser Thr Ser Leu Gly Ile Met Val Arg Ala Arg 
545                 550                 555                 560 


Asp Thr Ala Ser Pro Ile Gly Ala Phe Met Trp Pro Leu His Trp Ser 
                565                 570                 575     


Thr Trp Leu Gly Val Phe Ala Ala Leu His Leu Thr Ala Leu Phe Leu 
            580                 585                 590         


Thr Val Tyr Glu Trp Arg Ser Pro Tyr Gly Leu Thr Pro Arg Gly Arg 
        595                 600                 605             


Asn Arg Ser Thr Val Phe Ser Tyr Ser Ser Ala Leu Asn Leu Cys Tyr 
    610                 615                 620                 


Ala Ile Leu Phe Arg Arg Thr Val Ser Ser Lys Thr Pro Lys Cys Pro 
625                 630                 635                 640 


Thr Gly Arg Leu Leu Met Asn Leu Trp Ala Ile Phe Cys Leu Leu Val 
                645                 650                 655     


Leu Ser Ser Tyr Thr Ala Asn Leu Ala Ala Val Met Val Gly Asp Lys 
            660                 665                 670         


Thr Phe Glu Glu Leu Ser Gly Ile His Asp Pro Lys Leu His His Pro 
        675                 680                 685             


Ala Gln Gly Phe Arg Phe Gly Thr Val Trp Glu Ser Ser Ala Glu Ala 
    690                 695                 700                 


Tyr Ile Lys Lys Ser Phe Pro Asp Met His Ala His Met Arg Arg His 
705                 710                 715                 720 


Ser Ala Pro Thr Thr Pro Arg Gly Val Ala Met Leu Thr Ser Asp Pro 
                725                 730                 735     


Pro Lys Leu Asn Ala Phe Ile Met Asp Lys Ser Leu Leu Asp Tyr Glu 
            740                 745                 750         


Val Ser Ile Asp Ala Asp Cys Lys Leu Leu Thr Val Gly Lys Pro Phe 
        755                 760                 765             


Ala Ile Glu Gly Tyr Gly Ile Gly Leu Pro Gln Asn Ser Pro Leu Thr 
    770                 775                 780                 


Ser Asn Leu Ser Glu Phe Ile Ser Arg Tyr Lys Ser Ser Gly Phe Ile 
785                 790                 795                 800 


Asp Leu Leu His Asp Lys Trp Tyr Lys Met Val Pro Cys Gly Lys Arg 
                805                 810                 815     


Val Phe Ala Val Thr Glu Thr Leu Gln Met Ser Ile Tyr His Phe Ala 
            820                 825                 830         


Gly Leu Phe Val Leu Leu Cys Leu Gly Leu Gly Ser Ala Leu Leu Ser 
        835                 840                 845             


Ser Leu Gly Glu His Ala Phe Phe Arg Leu Ala Leu Pro Arg Ile Arg 
    850                 855                 860                 


Lys Gly Ser Arg Leu Gln Tyr Trp Leu His Thr Ser Gln Lys Ile His 
865                 870                 875                 880 


Arg Ala Leu Asn Thr Glu Pro Pro Glu Gly Ser Lys Glu Glu Thr Ala 
                885                 890                 895     


Glu Ala Glu Pro Ser Gly Pro Glu Val Glu Gln Gln Gln Gln Gln Gln 
            900                 905                 910         


Asp Gln Pro Thr Ala Pro Glu Gly Trp Lys Arg Ala Arg Arg Ala Val 
        915                 920                 925             


Asp Lys Glu Arg Arg Val Arg Phe Leu Leu Glu Pro Ala Val Val Val 
    930                 935                 940                 


Ala Pro Glu Ala Asp Ala Glu Ala Glu Ala Ala Pro Arg Glu Gly Pro 
945                 950                 955                 960 


Val Trp Leu Cys Ser Tyr Gly Arg Pro Pro Ala Ala Arg Pro Thr Gly 
                965                 970                 975     


Ala Pro Gln Pro Gly Glu Leu Gln Glu Leu Glu Arg Arg Ile Glu Val 
            980                 985                 990         


Ala Arg Glu Arg Leu Arg Gln Ala  Leu Val Arg Arg Gly  Gln Leu Leu 
        995                 1000                 1005             


Ala Gln  Leu Gly Asp Ser Ala  Arg His Arg Pro Arg  Arg Leu Leu 
    1010                 1015                 1020             


Gln Ala  Arg Ala Ala Pro Ala  Glu Ala Pro Pro His  Ser Gly Arg 
    1025                 1030                 1035             


Pro Gly  Ser Gln Glu 
    1040             


<210>  4731
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRINA__Homo_sapiens__NP_001009184

<400>  4731

Met Ser His Glu Lys Ser Phe Leu Val Ser Gly Asp Asn Tyr Pro Pro 
1               5                   10                  15      


Pro Asn Pro Gly Tyr Pro Gly Gly Pro Gln Pro Pro Met Pro Pro Tyr 
            20                  25                  30          


Ala Gln Pro Pro Tyr Pro Gly Ala Pro Tyr Pro Gln Pro Pro Phe Gln 
        35                  40                  45              


Pro Ser Pro Tyr Gly Gln Pro Gly Tyr Pro His Gly Pro Ser Pro Tyr 
    50                  55                  60                  


Pro Gln Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Gly Gly Tyr Pro 
65                  70                  75                  80  


Gln Gly Pro Tyr Pro Gln Glu Gly Tyr Pro Gln Gly Pro Tyr Pro Gln 
                85                  90                  95      


Gly Gly Tyr Pro Gln Gly Pro Tyr Pro Gln Ser Pro Phe Pro Pro Asn 
            100                 105                 110         


Pro Tyr Gly Gln Pro Gln Val Phe Pro Gly Gln Asp Pro Asp Ser Pro 
        115                 120                 125             


Gln His Gly Asn Tyr Gln Glu Glu Gly Pro Pro Ser Tyr Tyr Asp Asn 
    130                 135                 140                 


Gln Asp Phe Pro Ala Thr Asn Trp Asp Asp Lys Ser Ile Arg Gln Ala 
145                 150                 155                 160 


Phe Ile Arg Lys Val Phe Leu Val Leu Thr Leu Gln Leu Ser Val Thr 
                165                 170                 175     


Leu Ser Thr Val Ser Val Phe Thr Phe Val Ala Glu Val Lys Gly Phe 
            180                 185                 190         


Val Arg Glu Asn Val Trp Thr Tyr Tyr Val Ser Tyr Ala Val Phe Phe 
        195                 200                 205             


Ile Ser Leu Ile Val Leu Ser Cys Cys Gly Asp Phe Arg Arg Lys His 
    210                 215                 220                 


Pro Trp Asn Leu Val Ala Leu Ser Val Leu Thr Ala Ser Leu Ser Tyr 
225                 230                 235                 240 


Met Val Gly Met Ile Ala Ser Phe Tyr Asn Thr Glu Ala Val Ile Met 
                245                 250                 255     


Ala Val Gly Ile Thr Thr Ala Val Cys Phe Thr Val Val Ile Phe Ser 
            260                 265                 270         


Met Gln Thr Arg Tyr Asp Phe Thr Ser Cys Met Gly Val Leu Leu Val 
        275                 280                 285             


Ser Met Val Val Leu Phe Ile Phe Ala Ile Leu Cys Ile Phe Ile Arg 
    290                 295                 300                 


Asn Arg Ile Leu Glu Ile Val Tyr Ala Ser Leu Gly Ala Leu Leu Phe 
305                 310                 315                 320 


Thr Cys Phe Leu Ala Val Asp Thr Gln Leu Leu Leu Gly Asn Lys Gln 
                325                 330                 335     


Leu Ser Leu Ser Pro Glu Glu Tyr Val Phe Ala Ala Leu Asn Leu Tyr 
            340                 345                 350         


Thr Asp Ile Ile Asn Ile Phe Leu Tyr Ile Leu Thr Ile Ile Gly Arg 
        355                 360                 365             


Ala Lys Glu 
    370     


<210>  4732
<211>  1076
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRIP1__Homo_sapiens__NP_066973

<400>  4732

Met Ile Ala Val Ser Phe Lys Cys Arg Cys Gln Ile Leu Arg Arg Leu 
1               5                   10                  15      


Thr Lys Asp Glu Ser Pro Tyr Thr Lys Ser Ala Ser Gln Thr Lys Pro 
            20                  25                  30          


Pro Asp Gly Ala Leu Ala Val Arg Arg Gln Ser Ile Pro Glu Glu Phe 
        35                  40                  45              


Lys Gly Ser Thr Val Val Glu Leu Met Lys Lys Glu Gly Thr Thr Leu 
    50                  55                  60                  


Gly Leu Thr Val Ser Gly Gly Ile Asp Lys Asp Gly Lys Pro Arg Val 
65                  70                  75                  80  


Ser Asn Leu Arg Gln Gly Gly Ile Ala Ala Arg Ser Asp Gln Leu Asp 
                85                  90                  95      


Val Gly Asp Tyr Ile Lys Ala Val Asn Gly Ile Asn Leu Ala Lys Phe 
            100                 105                 110         


Arg His Asp Glu Ile Ile Ser Leu Leu Lys Asn Val Gly Glu Arg Val 
        115                 120                 125             


Val Leu Glu Val Glu Tyr Glu Leu Pro Pro Val Ser Val Gln Gly Ser 
    130                 135                 140                 


Ser Val Ile Phe Arg Thr Val Glu Val Thr Leu His Lys Glu Gly Asn 
145                 150                 155                 160 


Thr Phe Gly Phe Val Ile Arg Gly Gly Ala His Asp Asp Arg Asn Lys 
                165                 170                 175     


Ser Arg Pro Val Val Ile Thr Cys Val Arg Pro Gly Gly Pro Ala Asp 
            180                 185                 190         


Arg Glu Gly Thr Ile Lys Pro Gly Asp Arg Leu Leu Ser Val Asp Gly 
        195                 200                 205             


Ile Arg Leu Leu Gly Thr Thr His Ala Glu Ala Met Ser Ile Leu Lys 
    210                 215                 220                 


Gln Cys Gly Gln Glu Ala Ala Leu Leu Ile Glu Tyr Asp Val Ser Val 
225                 230                 235                 240 


Met Asp Ser Val Ala Thr Ala Ser Gly Pro Leu Leu Val Glu Val Ala 
                245                 250                 255     


Lys Thr Pro Gly Ala Ser Leu Gly Val Ala Leu Thr Thr Ser Met Cys 
            260                 265                 270         


Cys Asn Lys Gln Val Ile Val Ile Asp Lys Ile Lys Ser Ala Ser Ile 
        275                 280                 285             


Ala Asp Arg Cys Gly Ala Leu His Val Gly Asp His Ile Leu Ser Ile 
    290                 295                 300                 


Asp Gly Thr Ser Met Glu Tyr Cys Thr Leu Ala Glu Ala Thr Gln Phe 
305                 310                 315                 320 


Leu Ala Asn Thr Thr Asp Gln Val Lys Leu Glu Ile Leu Pro His His 
                325                 330                 335     


Gln Thr Arg Leu Ala Leu Lys Gly Pro Asp His Ala Ala Leu Val Ser 
            340                 345                 350         


Ser Ser Phe Ser Pro Thr Ser Met Ser Ala Tyr Ser Leu Ser Ser Leu 
        355                 360                 365             


Asn Met Gly Thr Leu Pro Arg Ser Leu Tyr Ser Thr Ser Pro Arg Gly 
    370                 375                 380                 


Thr Met Met Arg Arg Arg Leu Lys Lys Lys Asp Phe Lys Ser Ser Leu 
385                 390                 395                 400 


Ser Leu Ala Ser Ser Thr Val Gly Leu Ala Gly Gln Val Val His Thr 
                405                 410                 415     


Glu Thr Thr Glu Val Val Leu Thr Ala Asp Pro Val Thr Gly Phe Gly 
            420                 425                 430         


Ile Gln Leu Gln Gly Ser Val Phe Ala Thr Glu Thr Leu Ser Ser Pro 
        435                 440                 445             


Pro Leu Ile Ser Tyr Ile Glu Ala Asp Ser Pro Ala Glu Arg Cys Gly 
    450                 455                 460                 


Val Leu Gln Ile Gly Asp Arg Val Met Ala Ile Asn Gly Ile Pro Thr 
465                 470                 475                 480 


Glu Asp Ser Thr Phe Glu Glu Ala Ser Gln Leu Leu Arg Asp Ser Ser 
                485                 490                 495     


Ile Thr Ser Lys Val Thr Leu Glu Ile Glu Phe Asp Val Ala Glu Ser 
            500                 505                 510         


Val Ile Pro Ser Ser Gly Thr Phe His Val Lys Leu Pro Lys Lys His 
        515                 520                 525             


Asn Val Glu Leu Gly Ile Thr Ile Ser Ser Pro Ser Ser Arg Lys Pro 
    530                 535                 540                 


Gly Asp Pro Leu Val Ile Ser Asp Ile Lys Lys Gly Ser Val Ala His 
545                 550                 555                 560 


Arg Thr Gly Thr Leu Glu Leu Gly Asp Lys Leu Leu Ala Ile Asp Asn 
                565                 570                 575     


Ile Arg Leu Asp Asn Cys Ser Met Glu Asp Ala Val Gln Ile Leu Gln 
            580                 585                 590         


Gln Cys Glu Asp Leu Val Lys Leu Lys Ile Arg Lys Asp Glu Asp Asn 
        595                 600                 605             


Ser Asp Glu Gln Glu Ser Ser Gly Ala Ile Ile Tyr Thr Val Glu Leu 
    610                 615                 620                 


Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr Ile Ser Gly Thr Glu Glu 
625                 630                 635                 640 


Pro Phe Asp Pro Ile Ile Ile Ser Ser Leu Thr Lys Gly Gly Leu Ala 
                645                 650                 655     


Glu Arg Thr Gly Ala Ile His Ile Gly Asp Arg Ile Leu Ala Ile Asn 
            660                 665                 670         


Ser Ser Ser Leu Lys Gly Lys Pro Leu Ser Glu Ala Ile His Leu Leu 
        675                 680                 685             


Gln Met Ala Gly Glu Thr Val Thr Leu Lys Ile Lys Lys Gln Thr Asp 
    690                 695                 700                 


Ala Gln Ser Ala Ser Ser Pro Lys Lys Phe Pro Ile Ser Ser His Leu 
705                 710                 715                 720 


Ser Asp Leu Gly Asp Val Glu Glu Asp Ser Ser Pro Ala Gln Lys Pro 
                725                 730                 735     


Gly Lys Leu Ser Asp Met Tyr Pro Ser Thr Val Pro Ser Val Asp Ser 
            740                 745                 750         


Ala Val Asp Ser Trp Asp Gly Ser Ala Ile Asp Thr Ser Tyr Gly Thr 
        755                 760                 765             


Gln Gly Thr Ser Phe Gln Ala Ser Gly Tyr Asn Phe Asn Thr Tyr Asp 
    770                 775                 780                 


Trp Arg Ser Pro Lys Gln Arg Gly Ser Leu Ser Pro Val Thr Lys Pro 
785                 790                 795                 800 


Arg Ser Gln Thr Tyr Pro Asp Val Gly Leu Ser Tyr Glu Asp Trp Asp 
                805                 810                 815     


Arg Ser Thr Ala Ser Gly Phe Ala Gly Ala Ala Asp Ser Ala Glu Thr 
            820                 825                 830         


Glu Gln Glu Glu Asn Phe Trp Ser Gln Ala Leu Glu Asp Leu Glu Thr 
        835                 840                 845             


Cys Gly Gln Ser Gly Ile Leu Arg Glu Leu Glu Glu Lys Ala Asp Arg 
    850                 855                 860                 


Arg Val Ser Leu Arg Asn Met Thr Leu Leu Ala Thr Ile Met Ser Gly 
865                 870                 875                 880 


Ser Thr Met Ser Leu Asn His Glu Ala Pro Thr Pro Arg Ser Gln Leu 
                885                 890                 895     


Gly Arg Gln Ala Ser Phe Gln Glu Arg Ser Ser Ser Arg Pro His Tyr 
            900                 905                 910         


Ser Gln Thr Thr Arg Ser Asn Thr Leu Pro Ser Asp Val Gly Arg Lys 
        915                 920                 925             


Ser Val Thr Leu Arg Lys Met Lys Gln Glu Ile Lys Glu Ile Met Ser 
    930                 935                 940                 


Pro Thr Pro Val Glu Leu His Lys Val Thr Leu Tyr Lys Asp Ser Asp 
945                 950                 955                 960 


Met Glu Asp Phe Gly Phe Ser Val Ala Asp Gly Leu Leu Glu Lys Gly 
                965                 970                 975     


Val Tyr Val Lys Asn Ile Arg Pro Ala Gly Pro Gly Asp Leu Gly Gly 
            980                 985                 990         


Leu Lys Pro Tyr Asp Arg Leu Leu  Gln Val Asn His Val  Arg Thr Arg 
        995                 1000                 1005             


Asp Phe  Asp Cys Cys Leu Val  Val Pro Leu Ile Ala  Glu Ser Gly 
    1010                 1015                 1020             


Asn Lys  Leu Asp Leu Val Ile  Ser Arg Asn Pro Leu  Ala Ser Gln 
    1025                 1030                 1035             


Lys Ser  Ile Asp Gln Gln Ser  Leu Pro Gly Asp Trp  Ser Glu Gln 
    1040                 1045                 1050             


Asn Ser  Ala Phe Phe Gln Gln  Pro Ser His Gly Gly  Asn Leu Glu 
    1055                 1060                 1065             


Thr Arg  Glu Pro Thr Asn Thr  Leu 
    1070                 1075     


<210>  4733
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRK1__Homo_sapiens__NP_002920

<400>  4733

Met Asp Phe Gly Ser Leu Glu Thr Val Val Ala Asn Ser Ala Phe Ile 
1               5                   10                  15      


Ala Ala Arg Gly Ser Phe Asp Gly Ser Ser Ser Gln Pro Ser Arg Asp 
            20                  25                  30          


Lys Lys Tyr Leu Ala Lys Leu Lys Leu Pro Pro Leu Ser Lys Cys Glu 
        35                  40                  45              


Ser Leu Arg Asp Ser Leu Ser Leu Glu Phe Glu Ser Val Cys Leu Glu 
    50                  55                  60                  


Gln Pro Ile Gly Lys Lys Leu Phe Gln Gln Phe Leu Gln Ser Ala Glu 
65                  70                  75                  80  


Lys His Leu Pro Ala Leu Glu Leu Trp Lys Asp Ile Glu Asp Tyr Asp 
                85                  90                  95      


Thr Ala Asp Asn Asp Leu Gln Pro Gln Lys Ala Gln Thr Ile Leu Ala 
            100                 105                 110         


Gln Tyr Leu Asp Pro Gln Ala Lys Leu Phe Cys Ser Phe Leu Asp Glu 
        115                 120                 125             


Gly Ile Val Ala Lys Phe Lys Glu Gly Pro Val Glu Ile Gln Asp Gly 
    130                 135                 140                 


Leu Phe Gln Pro Leu Leu Gln Ala Thr Leu Ala His Leu Gly Gln Ala 
145                 150                 155                 160 


Pro Phe Gln Glu Tyr Leu Gly Ser Leu Tyr Phe Leu Arg Phe Leu Gln 
                165                 170                 175     


Trp Lys Trp Leu Glu Ala Gln Pro Met Gly Glu Asp Trp Phe Leu Asp 
            180                 185                 190         


Phe Arg Val Leu Gly Lys Gly Gly Phe Gly Glu Val Ser Ala Cys Gln 
        195                 200                 205             


Met Lys Ala Thr Gly Lys Leu Tyr Ala Cys Lys Lys Leu Asn Lys Lys 
    210                 215                 220                 


Arg Leu Lys Lys Arg Lys Gly Tyr Gln Gly Ala Met Val Glu Lys Lys 
225                 230                 235                 240 


Ile Leu Met Lys Val His Ser Arg Phe Ile Val Ser Leu Ala Tyr Ala 
                245                 250                 255     


Phe Glu Thr Lys Ala Asp Leu Cys Leu Val Met Thr Ile Met Asn Gly 
            260                 265                 270         


Gly Asp Ile Arg Tyr His Ile Tyr Asn Val Asn Glu Glu Asn Pro Gly 
        275                 280                 285             


Phe Pro Glu Pro Arg Ala Leu Phe Tyr Thr Ala Gln Ile Ile Cys Gly 
    290                 295                 300                 


Leu Glu His Leu His Gln Arg Arg Ile Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320 


Glu Asn Val Leu Leu Asp Asn Asp Gly Asn Val Arg Ile Ser Asp Leu 
                325                 330                 335     


Gly Leu Ala Val Glu Leu Leu Asp Gly Gln Ser Lys Thr Lys Gly Tyr 
            340                 345                 350         


Ala Gly Thr Pro Gly Phe Met Ala Pro Glu Leu Leu Gln Gly Glu Glu 
        355                 360                 365             


Tyr Asp Phe Ser Val Asp Tyr Phe Ala Leu Gly Val Thr Leu Tyr Glu 
    370                 375                 380                 


Met Ile Ala Ala Arg Gly Pro Phe Arg Ala Arg Gly Glu Lys Val Glu 
385                 390                 395                 400 


Asn Lys Glu Leu Lys His Arg Ile Ile Ser Glu Pro Val Lys Tyr Pro 
                405                 410                 415     


Asp Lys Phe Ser Gln Ala Ser Lys Asp Phe Cys Glu Ala Leu Leu Glu 
            420                 425                 430         


Lys Asp Pro Glu Lys Arg Leu Gly Phe Arg Asp Glu Thr Cys Asp Lys 
        435                 440                 445             


Leu Arg Ala His Pro Leu Phe Lys Asp Leu Asn Trp Arg Gln Leu Glu 
    450                 455                 460                 


Ala Gly Met Leu Met Pro Pro Phe Ile Pro Asp Ser Lys Thr Val Tyr 
465                 470                 475                 480 


Ala Lys Asp Ile Gln Asp Val Gly Ala Phe Ser Thr Val Lys Gly Val 
                485                 490                 495     


Ala Phe Asp Lys Thr Asp Thr Glu Phe Phe Gln Glu Phe Ala Thr Gly 
            500                 505                 510         


Asn Cys Pro Ile Pro Trp Gln Glu Glu Met Ile Glu Thr Gly Ile Phe 
        515                 520                 525             


Gly Glu Leu Asn Val Trp Arg Ser Asp Gly Gln Met Pro Asp Asp Met 
    530                 535                 540                 


Lys Gly Ile Ser Gly Gly Ser Ser Ser Ser Ser Lys Ser Gly Met Cys 
545                 550                 555                 560 


Leu Val Ser 
            


<210>  4734
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRK4__Homo_sapiens__NP_001004056

<400>  4734

Met Glu Leu Glu Asn Ile Val Ala Asn Ser Leu Leu Leu Lys Ala Arg 
1               5                   10                  15      


Gln Glu Lys Asp Tyr Ser Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
            20                  25                  30          


Arg Leu Phe Arg Gln Phe Cys Asp Thr Lys Pro Thr Leu Lys Arg His 
        35                  40                  45              


Ile Glu Phe Leu Asp Ala Val Ala Glu Tyr Glu Val Ala Asp Asp Glu 
    50                  55                  60                  


Asp Arg Ser Asp Cys Gly Leu Ser Ile Leu Asp Arg Phe Phe Asn Asp 
65                  70                  75                  80  


Lys Leu Ala Ala Pro Leu Pro Glu Ile Pro Pro Asp Val Val Thr Glu 
                85                  90                  95      


Cys Arg Leu Gly Leu Lys Glu Glu Asn Pro Ser Lys Lys Ala Phe Glu 
            100                 105                 110         


Glu Cys Thr Arg Val Ala His Asn Tyr Leu Arg Gly Glu Pro Phe Glu 
        115                 120                 125             


Glu Tyr Gln Glu Ser Ser Tyr Phe Ser Gln Phe Leu Gln Trp Lys Trp 
    130                 135                 140                 


Leu Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg His Tyr Arg Val 
145                 150                 155                 160 


Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala 
                165                 170                 175     


Thr Gly Lys Met Tyr Ala Cys Lys Lys Leu Gln Lys Lys Arg Ile Lys 
            180                 185                 190         


Lys Arg Lys Gly Glu Ala Met Ala Leu Asn Glu Lys Arg Ile Leu Glu 
        195                 200                 205             


Lys Val Gln Ser Arg Phe Val Val Ser Leu Ala Tyr Ala Tyr Glu Thr 
    210                 215                 220                 


Lys Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu 
225                 230                 235                 240 


Lys Phe His Ile Tyr Asn Leu Gly Asn Pro Gly Phe Asp Glu Gln Arg 
                245                 250                 255     


Ala Val Phe Tyr Ala Ala Glu Leu Cys Cys Gly Leu Glu Asp Leu Gln 
            260                 265                 270         


Arg Glu Arg Ile Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu 
        275                 280                 285             


Asp Asp Arg Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Thr Glu 
    290                 295                 300                 


Ile Pro Glu Gly Gln Arg Val Arg Gly Arg Val Gly Thr Val Gly Tyr 
305                 310                 315                 320 


Met Ala Pro Glu Val Val Asn Asn Glu Lys Tyr Thr Phe Ser Pro Asp 
                325                 330                 335     


Trp Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Gln Gly His Ser 
            340                 345                 350         


Pro Phe Lys Lys Tyr Lys Glu Lys Val Lys Trp Glu Glu Val Asp Gln 
        355                 360                 365             


Arg Ile Lys Asn Asp Thr Glu Glu Tyr Ser Glu Lys Phe Ser Glu Asp 
    370                 375                 380                 


Ala Lys Ser Ile Cys Arg Met Leu Leu Thr Lys Asn Pro Ser Lys Arg 
385                 390                 395                 400 


Leu Gly Cys Arg Gly Glu Gly Ala Ala Gly Val Lys Gln His Pro Val 
                405                 410                 415     


Phe Lys Asp Ile Asn Phe Arg Arg Leu Glu Ala Asn Met Leu Glu Pro 
            420                 425                 430         


Pro Phe Cys Pro Asp Pro His Ala Val Tyr Cys Lys Asp Val Leu Asp 
        435                 440                 445             


Ile Glu Gln Phe Ser Val Val Lys Gly Ile Tyr Leu Asp Thr Ala Asp 
    450                 455                 460                 


Glu Asp Phe Tyr Ala Arg Phe Ala Thr Gly Cys Val Ser Ile Pro Trp 
465                 470                 475                 480 


Gln Asn Glu Met Ile Glu Ser Gly Cys Phe Lys Asp Ile Asn Lys Ser 
                485                 490                 495     


Glu Ser Glu Glu Ala Leu Pro Leu Asp Leu Asp Lys Asn Ile His Thr 
            500                 505                 510         


Pro Val Ser Arg Pro Asn Arg Gly Phe Phe Tyr Arg Leu Phe Arg Arg 
        515                 520                 525             


Gly Gly Cys Leu Thr Met Val Pro Ser Glu Lys Glu Val Glu Pro Lys 
    530                 535                 540                 


Gln Cys 
545     


<210>  4735
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRK5__Homo_sapiens__NP_005299

<400>  4735

Met Glu Leu Glu Asn Ile Val Ala Asn Thr Val Leu Leu Lys Ala Arg 
1               5                   10                  15      


Glu Gly Gly Gly Gly Lys Arg Lys Gly Lys Ser Lys Lys Trp Lys Glu 
            20                  25                  30          


Ile Leu Lys Phe Pro His Ile Ser Gln Cys Glu Asp Leu Arg Arg Thr 
        35                  40                  45              


Ile Asp Arg Asp Tyr Cys Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
    50                  55                  60                  


Leu Leu Phe Arg Gln Phe Cys Glu Thr Arg Pro Gly Leu Glu Cys Tyr 
65                  70                  75                  80  


Ile Gln Phe Leu Asp Ser Val Ala Glu Tyr Glu Val Thr Pro Asp Glu 
                85                  90                  95      


Lys Leu Gly Glu Lys Gly Lys Glu Ile Met Thr Lys Tyr Leu Thr Pro 
            100                 105                 110         


Lys Ser Pro Val Phe Ile Ala Gln Val Gly Gln Asp Leu Val Ser Gln 
        115                 120                 125             


Thr Glu Glu Lys Leu Leu Gln Lys Pro Cys Lys Glu Leu Phe Ser Ala 
    130                 135                 140                 


Cys Ala Gln Ser Val His Glu Tyr Leu Arg Gly Glu Pro Phe His Glu 
145                 150                 155                 160 


Tyr Leu Asp Ser Met Phe Phe Asp Arg Phe Leu Gln Trp Lys Trp Leu 
                165                 170                 175     


Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu 
            180                 185                 190         


Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala Thr 
        195                 200                 205             


Gly Lys Met Tyr Ala Cys Lys Arg Leu Glu Lys Lys Arg Ile Lys Lys 
    210                 215                 220                 


Arg Lys Gly Glu Ser Met Ala Leu Asn Glu Lys Gln Ile Leu Glu Lys 
225                 230                 235                 240 


Val Asn Ser Gln Phe Val Val Asn Leu Ala Tyr Ala Tyr Glu Thr Lys 
                245                 250                 255     


Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu Lys 
            260                 265                 270         


Phe His Ile Tyr Asn Met Gly Asn Pro Gly Phe Glu Glu Glu Arg Ala 
        275                 280                 285             


Leu Phe Tyr Ala Ala Glu Ile Leu Cys Gly Leu Glu Asp Leu His Arg 
    290                 295                 300                 


Glu Asn Thr Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Asp Tyr Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Val Lys Ile 
                325                 330                 335     


Pro Glu Gly Asp Leu Ile Arg Gly Arg Val Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ala Pro Glu Val Leu Asn Asn Gln Arg Tyr Gly Leu Ser Pro Asp Tyr 
        355                 360                 365             


Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Glu Gly Gln Ser Pro 
    370                 375                 380                 


Phe Arg Gly Arg Lys Glu Lys Val Lys Arg Glu Glu Val Asp Arg Arg 
385                 390                 395                 400 


Val Leu Glu Thr Glu Glu Val Tyr Ser His Lys Phe Ser Glu Glu Ala 
                405                 410                 415     


Lys Ser Ile Cys Lys Met Leu Leu Thr Lys Asp Ala Lys Gln Arg Leu 
            420                 425                 430         


Gly Cys Gln Glu Glu Gly Ala Ala Glu Val Lys Arg His Pro Phe Phe 
        435                 440                 445             


Arg Asn Met Asn Phe Lys Arg Leu Glu Ala Gly Met Leu Asp Pro Pro 
    450                 455                 460                 


Phe Val Pro Asp Pro Arg Ala Val Tyr Cys Lys Asp Val Leu Asp Ile 
465                 470                 475                 480 


Glu Gln Phe Ser Thr Val Lys Gly Val Asn Leu Asp His Thr Asp Asp 
                485                 490                 495     


Asp Phe Tyr Ser Lys Phe Ser Thr Gly Ser Val Ser Ile Pro Trp Gln 
            500                 505                 510         


Asn Glu Met Ile Glu Thr Glu Cys Phe Lys Glu Leu Asn Val Phe Gly 
        515                 520                 525             


Pro Asn Gly Thr Leu Pro Pro Asp Leu Asn Arg Asn His Pro Pro Glu 
    530                 535                 540                 


Pro Pro Lys Lys Gly Leu Leu Gln Arg Leu Phe Lys Arg Gln His Gln 
545                 550                 555                 560 


Asn Asn Ser Lys Ser Ser Pro Ser Ser Lys Thr Ser Phe Asn His His 
                565                 570                 575     


Ile Asn Ser Asn His Val Ser Ser Asn Ser Thr Gly Ser Ser 
            580                 585                 590 


<210>  4736
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRK6__Homo_sapiens__NP_001004105

<400>  4736

Met Glu Leu Glu Asn Ile Val Ala Asn Thr Val Leu Leu Lys Ala Arg 
1               5                   10                  15      


Glu Gly Gly Gly Gly Asn Arg Lys Gly Lys Ser Lys Lys Trp Arg Gln 
            20                  25                  30          


Met Leu Gln Phe Pro His Ile Ser Gln Cys Glu Glu Leu Arg Leu Ser 
        35                  40                  45              


Leu Glu Arg Asp Tyr His Ser Leu Cys Glu Arg Gln Pro Ile Gly Arg 
    50                  55                  60                  


Leu Leu Phe Arg Glu Phe Cys Ala Thr Arg Pro Glu Leu Ser Arg Cys 
65                  70                  75                  80  


Val Ala Phe Leu Asp Gly Val Ala Glu Tyr Glu Val Thr Pro Asp Asp 
                85                  90                  95      


Lys Arg Lys Ala Cys Gly Arg Gln Leu Thr Gln Asn Phe Leu Ser His 
            100                 105                 110         


Thr Gly Pro Asp Leu Ile Pro Glu Val Pro Arg Gln Leu Val Thr Asn 
        115                 120                 125             


Cys Thr Gln Arg Leu Glu Gln Gly Pro Cys Lys Asp Leu Phe Gln Glu 
    130                 135                 140                 


Leu Thr Arg Leu Thr His Glu Tyr Leu Ser Val Ala Pro Phe Ala Asp 
145                 150                 155                 160 


Tyr Leu Asp Ser Ile Tyr Phe Asn Arg Phe Leu Gln Trp Lys Trp Leu 
                165                 170                 175     


Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu 
            180                 185                 190         


Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala Thr 
        195                 200                 205             


Gly Lys Met Tyr Ala Cys Lys Lys Leu Glu Lys Lys Arg Ile Lys Lys 
    210                 215                 220                 


Arg Lys Gly Glu Ala Met Ala Leu Asn Glu Lys Gln Ile Leu Glu Lys 
225                 230                 235                 240 


Val Asn Ser Arg Phe Val Val Ser Leu Ala Tyr Ala Tyr Glu Thr Lys 
                245                 250                 255     


Asp Ala Leu Cys Leu Val Leu Thr Leu Met Asn Gly Gly Asp Leu Lys 
            260                 265                 270         


Phe His Ile Tyr His Met Gly Gln Ala Gly Phe Pro Glu Ala Arg Ala 
        275                 280                 285             


Val Phe Tyr Ala Ala Glu Ile Cys Cys Gly Leu Glu Asp Leu His Arg 
    290                 295                 300                 


Glu Arg Ile Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Asp His Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Val His Val 
                325                 330                 335     


Pro Glu Gly Gln Thr Ile Lys Gly Arg Val Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ala Pro Glu Val Val Lys Asn Glu Arg Tyr Thr Phe Ser Pro Asp Trp 
        355                 360                 365             


Trp Ala Leu Gly Cys Leu Leu Tyr Glu Met Ile Ala Gly Gln Ser Pro 
    370                 375                 380                 


Phe Gln Gln Arg Lys Lys Lys Ile Lys Arg Glu Glu Val Glu Arg Leu 
385                 390                 395                 400 


Val Lys Glu Val Pro Glu Glu Tyr Ser Glu Arg Phe Ser Pro Gln Ala 
                405                 410                 415     


Arg Ser Leu Cys Ser Gln Leu Leu Cys Lys Asp Pro Ala Glu Arg Leu 
            420                 425                 430         


Gly Cys Arg Gly Gly Ser Ala Arg Glu Val Lys Glu His Pro Leu Phe 
        435                 440                 445             


Lys Lys Leu Asn Phe Lys Arg Leu Gly Ala Gly Met Leu Glu Pro Pro 
    450                 455                 460                 


Phe Lys Pro Asp Pro Gln Ala Ile Tyr Cys Lys Asp Val Leu Asp Ile 
465                 470                 475                 480 


Glu Gln Phe Ser Thr Val Lys Gly Val Glu Leu Glu Pro Thr Asp Gln 
                485                 490                 495     


Asp Phe Tyr Gln Lys Phe Ala Thr Gly Ser Val Pro Ile Pro Trp Gln 
            500                 505                 510         


Asn Glu Met Val Glu Thr Glu Cys Phe Gln Glu Leu Asn Val Phe Gly 
        515                 520                 525             


Leu Asp Gly Ser Val Pro Pro Asp Leu Asp Trp Lys Gly Gln Pro Pro 
    530                 535                 540                 


Ala Pro Pro Lys Lys Gly Leu Leu Gln Arg Leu Phe Ser Arg Gln Arg 
545                 550                 555                 560 


<210>  4737
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRK7__Homo_sapiens__NP_631948

<400>  4737

Met Val Asp Met Gly Ala Leu Asp Asn Leu Ile Ala Asn Thr Ala Tyr 
1               5                   10                  15      


Leu Gln Ala Arg Lys Pro Ser Asp Cys Asp Ser Lys Glu Leu Gln Arg 
            20                  25                  30          


Arg Arg Arg Ser Leu Ala Leu Pro Gly Leu Gln Gly Cys Ala Glu Leu 
        35                  40                  45              


Arg Gln Lys Leu Ser Leu Asn Phe His Ser Leu Cys Glu Gln Gln Pro 
    50                  55                  60                  


Ile Gly Arg Arg Leu Phe Arg Asp Phe Leu Ala Thr Val Pro Thr Phe 
65                  70                  75                  80  


Arg Lys Ala Ala Thr Phe Leu Glu Asp Val Gln Asn Trp Glu Leu Ala 
                85                  90                  95      


Glu Glu Gly Pro Thr Lys Asp Ser Ala Leu Gln Gly Leu Val Ala Thr 
            100                 105                 110         


Cys Ala Ser Ala Pro Ala Pro Gly Asn Pro Gln Pro Phe Leu Ser Gln 
        115                 120                 125             


Ala Val Ala Thr Lys Cys Gln Ala Ala Thr Thr Glu Glu Glu Arg Val 
    130                 135                 140                 


Ala Ala Val Thr Leu Ala Lys Ala Glu Ala Met Ala Phe Leu Gln Glu 
145                 150                 155                 160 


Gln Pro Phe Lys Asp Phe Val Thr Ser Ala Phe Tyr Asp Lys Phe Leu 
                165                 170                 175     


Gln Trp Lys Leu Phe Glu Met Gln Pro Val Ser Asp Lys Tyr Phe Thr 
            180                 185                 190         


Glu Phe Arg Val Leu Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Val 
        195                 200                 205             


Gln Val Lys Asn Thr Gly Lys Met Tyr Ala Cys Lys Lys Leu Asp Lys 
    210                 215                 220                 


Lys Arg Leu Lys Lys Lys Gly Gly Glu Lys Met Ala Leu Leu Glu Lys 
225                 230                 235                 240 


Glu Ile Leu Glu Lys Val Ser Ser Pro Phe Ile Val Ser Leu Ala Tyr 
                245                 250                 255     


Ala Phe Glu Ser Lys Thr His Leu Cys Leu Val Met Ser Leu Met Asn 
            260                 265                 270         


Gly Gly Asp Leu Lys Phe His Ile Tyr Asn Val Gly Thr Arg Gly Leu 
        275                 280                 285             


Asp Met Ser Arg Val Ile Phe Tyr Ser Ala Gln Ile Ala Cys Gly Met 
    290                 295                 300                 


Leu His Leu His Glu Leu Gly Ile Val Tyr Arg Asp Met Lys Pro Glu 
305                 310                 315                 320 


Asn Val Leu Leu Asp Asp Leu Gly Asn Cys Arg Leu Ser Asp Leu Gly 
                325                 330                 335     


Leu Ala Val Glu Met Lys Gly Gly Lys Pro Ile Thr Gln Arg Ala Gly 
            340                 345                 350         


Thr Asn Gly Tyr Met Ala Pro Glu Ile Leu Met Glu Lys Val Ser Tyr 
        355                 360                 365             


Ser Tyr Pro Val Asp Trp Phe Ala Met Gly Cys Ser Ile Tyr Glu Met 
    370                 375                 380                 


Val Ala Gly Arg Thr Pro Phe Lys Asp Tyr Lys Glu Lys Val Ser Lys 
385                 390                 395                 400 


Glu Asp Leu Lys Gln Arg Thr Leu Gln Asp Glu Val Lys Phe Gln His 
                405                 410                 415     


Asp Asn Phe Thr Glu Glu Ala Lys Asp Ile Cys Arg Leu Phe Leu Ala 
            420                 425                 430         


Lys Lys Pro Glu Gln Arg Leu Gly Ser Arg Glu Lys Ser Asp Asp Pro 
        435                 440                 445             


Arg Lys His His Phe Phe Lys Thr Ile Asn Phe Pro Arg Leu Glu Ala 
    450                 455                 460                 


Gly Leu Ile Glu Pro Pro Phe Val Pro Asp Pro Ser Val Val Tyr Ala 
465                 470                 475                 480 


Lys Asp Ile Ala Glu Ile Asp Asp Phe Ser Glu Val Arg Gly Val Glu 
                485                 490                 495     


Phe Asp Asp Lys Asp Lys Gln Phe Phe Lys Asn Phe Ala Thr Gly Ala 
            500                 505                 510         


Val Pro Ile Ala Trp Gln Glu Glu Ile Ile Glu Thr Gly Leu Phe Glu 
        515                 520                 525             


Glu Leu Asn Asp Pro Asn Arg Pro Thr Gly Cys Glu Glu Gly Asn Ser 
    530                 535                 540                 


Ser Lys Ser Gly Val Cys Leu Leu Leu 
545                 550             


<210>  4738
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM1__Homo_sapiens__NP_001264995

<400>  4738

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Lys Lys Arg Gln Pro Glu Phe Ser Pro Thr 
                885                 890                 895     


Ser Gln Cys Pro Ser Ala His Val Gln Leu 
            900                 905     


<210>  4739
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM2__Homo_sapiens__NP_000830

<400>  4739

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Ala Pro Phe 
            420                 425                 430         


Arg Pro Ala Asp Thr His Asn Glu Val Arg Phe Asp Arg Phe Gly Asp 
        435                 440                 445             


Gly Ile Gly Arg Tyr Asn Ile Phe Thr Tyr Leu Arg Ala Gly Ser Gly 
    450                 455                 460                 


Arg Tyr Arg Tyr Gln Lys Val Gly Tyr Trp Ala Glu Gly Leu Thr Leu 
465                 470                 475                 480 


Asp Thr Ser Leu Ile Pro Trp Ala Ser Pro Ser Ala Gly Pro Leu Pro 
                485                 490                 495     


Ala Ser Arg Cys Ser Glu Pro Cys Leu Gln Asn Glu Val Lys Ser Val 
            500                 505                 510         


Gln Pro Gly Glu Val Cys Cys Trp Leu Cys Ile Pro Cys Gln Pro Tyr 
        515                 520                 525             


Glu Tyr Arg Leu Asp Glu Phe Thr Cys Ala Asp Cys Gly Leu Gly Tyr 
    530                 535                 540                 


Trp Pro Asn Ala Ser Leu Thr Gly Cys Phe Glu Leu Pro Gln Glu Tyr 
545                 550                 555                 560 


Ile Arg Trp Gly Asp Ala Trp Ala Val Gly Pro Val Thr Ile Ala Cys 
                565                 570                 575     


Leu Gly Ala Leu Ala Thr Leu Phe Val Leu Gly Val Phe Val Arg His 
            580                 585                 590         


Asn Ala Thr Pro Val Val Lys Ala Ser Gly Arg Glu Leu Cys Tyr Ile 
        595                 600                 605             


Leu Leu Gly Gly Val Phe Leu Cys Tyr Cys Met Thr Phe Ile Phe Ile 
    610                 615                 620                 


Ala Lys Pro Ser Thr Ala Val Cys Thr Leu Arg Arg Leu Gly Leu Gly 
625                 630                 635                 640 


Thr Ala Phe Ser Val Cys Tyr Ser Ala Leu Leu Thr Lys Thr Asn Arg 
                645                 650                 655     


Ile Ala Arg Ile Phe Gly Gly Ala Arg Glu Gly Ala Gln Arg Pro Arg 
            660                 665                 670         


Phe Ile Ser Pro Ala Ser Gln Val Ala Ile Cys Leu Ala Leu Ile Ser 
        675                 680                 685             


Gly Gln Leu Leu Ile Val Val Ala Trp Leu Val Val Glu Ala Pro Gly 
    690                 695                 700                 


Thr Gly Lys Glu Thr Ala Pro Glu Arg Arg Glu Val Val Thr Leu Arg 
705                 710                 715                 720 


Cys Asn His Arg Asp Ala Ser Met Leu Gly Ser Leu Ala Tyr Asn Val 
                725                 730                 735     


Leu Leu Ile Ala Leu Cys Thr Leu Tyr Ala Phe Lys Thr Arg Lys Cys 
            740                 745                 750         


Pro Glu Asn Phe Asn Glu Ala Lys Phe Ile Gly Phe Thr Met Tyr Thr 
        755                 760                 765             


Thr Cys Ile Ile Trp Leu Ala Phe Leu Pro Ile Phe Tyr Val Thr Ser 
    770                 775                 780                 


Ser Asp Tyr Arg Val Gln Thr Thr Thr Met Cys Val Ser Val Ser Leu 
785                 790                 795                 800 


Ser Gly Ser Val Val Leu Gly Cys Leu Phe Ala Pro Lys Leu His Ile 
                805                 810                 815     


Ile Leu Phe Gln Pro Gln Lys Asn Val Val Ser His Arg Ala Pro Thr 
            820                 825                 830         


Ser Arg Phe Gly Ser Ala Ala Ala Arg Ala Ser Ser Ser Leu Gly Gln 
        835                 840                 845             


Gly Ser Gly Ser Gln Phe Val Pro Thr Val Cys Asn Gly Arg Glu Val 
    850                 855                 860                 


Val Asp Ser Thr Thr Ser Ser Leu 
865                 870         


<210>  4740
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM3__Homo_sapiens__NP_000831

<400>  4740

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Ala Pro Phe Asn Pro Asn Lys 
        435                 440                 445             


Asp Ala Asp Ser Ile Val Lys Phe Asp Thr Phe Gly Asp Gly Met Gly 
    450                 455                 460                 


Arg Tyr Asn Val Phe Asn Phe Gln Asn Val Gly Gly Lys Tyr Ser Tyr 
465                 470                 475                 480 


Leu Lys Val Gly His Trp Ala Glu Thr Leu Ser Leu Asp Val Asn Ser 
                485                 490                 495     


Ile His Trp Ser Arg Asn Ser Val Pro Thr Ser Gln Cys Ser Asp Pro 
            500                 505                 510         


Cys Ala Pro Asn Glu Met Lys Asn Met Gln Pro Gly Asp Val Cys Cys 
        515                 520                 525             


Trp Ile Cys Ile Pro Cys Glu Pro Tyr Glu Tyr Leu Ala Asp Glu Phe 
    530                 535                 540                 


Thr Cys Met Asp Cys Gly Ser Gly Gln Trp Pro Thr Ala Asp Leu Thr 
545                 550                 555                 560 


Gly Cys Tyr Asp Leu Pro Glu Asp Tyr Ile Arg Trp Glu Asp Ala Trp 
                565                 570                 575     


Ala Ile Gly Pro Val Thr Ile Ala Cys Leu Gly Phe Met Cys Thr Cys 
            580                 585                 590         


Met Val Val Thr Val Phe Ile Lys His Asn Asn Thr Pro Leu Val Lys 
        595                 600                 605             


Ala Ser Gly Arg Glu Leu Cys Tyr Ile Leu Leu Phe Gly Val Gly Leu 
    610                 615                 620                 


Ser Tyr Cys Met Thr Phe Phe Phe Ile Ala Lys Pro Ser Pro Val Ile 
625                 630                 635                 640 


Cys Ala Leu Arg Arg Leu Gly Leu Gly Ser Ser Phe Ala Ile Cys Tyr 
                645                 650                 655     


Ser Ala Leu Leu Thr Lys Thr Asn Cys Ile Ala Arg Ile Phe Asp Gly 
            660                 665                 670         


Val Lys Asn Gly Ala Gln Arg Pro Lys Phe Ile Ser Pro Ser Ser Gln 
        675                 680                 685             


Val Phe Ile Cys Leu Gly Leu Ile Leu Val Gln Ile Val Met Val Ser 
    690                 695                 700                 


Val Trp Leu Ile Leu Glu Ala Pro Gly Thr Arg Arg Tyr Thr Leu Ala 
705                 710                 715                 720 


Glu Lys Arg Glu Thr Val Ile Leu Lys Cys Asn Val Lys Asp Ser Ser 
                725                 730                 735     


Met Leu Ile Ser Leu Thr Tyr Asp Val Ile Leu Val Ile Leu Cys Thr 
            740                 745                 750         


Val Tyr Ala Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala 
        755                 760                 765             


Lys Phe Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
    770                 775                 780                 


Phe Leu Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr 
785                 790                 795                 800 


Thr Thr Met Cys Ile Ser Val Ser Leu Ser Gly Phe Val Val Leu Gly 
                805                 810                 815     


Cys Leu Phe Ala Pro Lys Val His Ile Ile Leu Phe Gln Pro Gln Lys 
            820                 825                 830         


Asn Val Val Thr His Arg Leu His Leu Asn Arg Phe Ser Val Ser Gly 
        835                 840                 845             


Thr Gly Thr Thr Tyr Ser Gln Ser Ser Ala Ser Thr Tyr Val Pro Thr 
    850                 855                 860                 


Val Cys Asn Gly Arg Glu Val Leu Asp Ser Thr Thr Ser Ser Leu 
865                 870                 875                 


<210>  4741
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM4__Homo_sapiens__NP_000832

<400>  4741

Met Pro Gly Lys Arg Gly Leu Gly Trp Trp Trp Ala Arg Leu Pro Leu 
1               5                   10                  15      


Cys Leu Leu Leu Ser Leu Tyr Gly Pro Trp Met Pro Ser Ser Leu Gly 
            20                  25                  30          


Lys Pro Lys Gly His Pro His Met Asn Ser Ile Arg Ile Asp Gly Asp 
        35                  40                  45              


Ile Thr Leu Gly Gly Leu Phe Pro Val His Gly Arg Gly Ser Glu Gly 
    50                  55                  60                  


Lys Pro Cys Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Phe Ala Leu Asp Arg Ile Asn Asn Asp Pro Asp Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr His Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu 
        115                 120                 125             


Lys Asp Gly Thr Glu Val Arg Cys Gly Ser Gly Gly Pro Pro Ile Ile 
    130                 135                 140                 


Thr Lys Pro Glu Arg Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Asp Leu Ser Asp Asn Ser Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Ser Asp Thr Tyr Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Arg Ala Leu Lys Trp Asn Tyr Val Ser Thr Val 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Ser Gly Val Glu Ala Phe Ile Gln 
225                 230                 235                 240 


Lys Ser Arg Glu Asp Gly Gly Val Cys Ile Ala Gln Ser Val Lys Ile 
                245                 250                 255     


Pro Arg Glu Pro Lys Ala Gly Glu Phe Asp Lys Ile Ile Arg Arg Leu 
            260                 265                 270         


Leu Glu Thr Ser Asn Ala Arg Ala Val Ile Ile Phe Ala Asn Glu Asp 
        275                 280                 285             


Asp Ile Arg Arg Val Leu Glu Ala Ala Arg Arg Ala Asn Gln Thr Gly 
    290                 295                 300                 


His Phe Phe Trp Met Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro 
305                 310                 315                 320 


Val Leu His Leu Glu Glu Val Ala Glu Gly Ala Val Thr Ile Leu Pro 
                325                 330                 335     


Lys Arg Met Ser Val Arg Gly Phe Asp Arg Tyr Phe Ser Ser Arg Thr 
            340                 345                 350         


Leu Asp Asn Asn Arg Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Asp 
        355                 360                 365             


Asn Phe His Cys Lys Leu Ser Arg His Ala Leu Lys Lys Gly Ser His 
    370                 375                 380                 


Val Lys Lys Cys Thr Asn Arg Glu Arg Ile Gly Gln Asp Ser Ala Tyr 
385                 390                 395                 400 


Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ala Met 
                405                 410                 415     


Gly His Ala Leu His Ala Met His Arg Asp Leu Cys Pro Gly Arg Val 
            420                 425                 430         


Gly Leu Cys Pro Arg Met Asp Pro Val Asp Gly Thr Gln Leu Leu Lys 
        435                 440                 445             


Tyr Ile Arg Asn Val Asn Phe Ser Gly Ile Ala Gly Asn Pro Val Thr 
    450                 455                 460                 


Phe Asn Glu Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Tyr Gln Tyr 
465                 470                 475                 480 


Gln Leu Arg Asn Asp Ser Ala Glu Tyr Lys Val Ile Gly Ser Trp Thr 
                485                 490                 495     


Asp His Leu His Leu Arg Ile Glu Arg Met His Trp Pro Gly Ser Gly 
            500                 505                 510         


Gln Gln Leu Pro Arg Ser Ile Cys Ser Leu Pro Cys Gln Pro Gly Glu 
        515                 520                 525             


Arg Lys Lys Thr Val Lys Gly Met Pro Cys Cys Trp His Cys Glu Pro 
    530                 535                 540                 


Cys Thr Gly Tyr Gln Tyr Gln Val Asp Arg Tyr Thr Cys Lys Thr Cys 
545                 550                 555                 560 


Pro Tyr Asp Met Arg Pro Thr Glu Asn Arg Thr Gly Cys Arg Pro Ile 
                565                 570                 575     


Pro Ile Ile Lys Leu Glu Trp Gly Ser Pro Trp Ala Val Leu Pro Leu 
            580                 585                 590         


Phe Leu Ala Val Val Gly Ile Ala Ala Thr Leu Phe Val Val Ile Thr 
        595                 600                 605             


Phe Val Arg Tyr Asn Asp Thr Pro Ile Val Lys Ala Ser Gly Arg Glu 
    610                 615                 620                 


Leu Ser Tyr Val Leu Leu Ala Gly Ile Phe Leu Cys Tyr Ala Thr Thr 
625                 630                 635                 640 


Phe Leu Met Ile Ala Glu Pro Asp Leu Gly Thr Cys Ser Leu Arg Arg 
                645                 650                 655     


Ile Phe Leu Gly Leu Gly Met Ser Ile Ser Tyr Ala Ala Leu Leu Thr 
            660                 665                 670         


Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val 
        675                 680                 685             


Ser Ala Pro Arg Phe Ile Ser Pro Ala Ser Gln Leu Ala Ile Thr Phe 
    690                 695                 700                 


Ser Leu Ile Ser Leu Gln Leu Leu Gly Ile Cys Val Trp Phe Val Val 
705                 710                 715                 720 


Asp Pro Ser His Ser Val Val Asp Phe Gln Asp Gln Arg Thr Leu Asp 
                725                 730                 735     


Pro Arg Phe Ala Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser 
            740                 745                 750         


Leu Ile Cys Leu Leu Gly Tyr Ser Met Leu Leu Met Val Thr Cys Thr 
        755                 760                 765             


Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala 
    770                 775                 780                 


Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val Trp Leu Ala 
785                 790                 795                 800 


Phe Ile Pro Ile Phe Phe Gly Thr Ser Gln Ser Ala Asp Lys Leu Tyr 
                805                 810                 815     


Ile Gln Thr Thr Thr Leu Thr Val Ser Val Ser Leu Ser Ala Ser Val 
            820                 825                 830         


Ser Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile Leu Phe His 
        835                 840                 845             


Pro Glu Gln Asn Val Pro Lys Arg Lys Arg Ser Leu Lys Ala Val Val 
    850                 855                 860                 


Thr Ala Ala Thr Met Ser Asn Lys Phe Thr Gln Lys Gly Asn Phe Arg 
865                 870                 875                 880 


Pro Asn Gly Glu Ala Lys Ser Glu Leu Cys Glu Asn Leu Glu Ala Pro 
                885                 890                 895     


Ala Leu Ala Thr Lys Gln Thr Tyr Val Thr Tyr Thr Asn His Ala Ile 
            900                 905                 910         


<210>  4742
<211>  1180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM5__Homo_sapiens__NP_000833

<400>  4742

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly 
865                 870                 875                 880 


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
                885                 890                 895     


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
            900                 905                 910         


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
        915                 920                 925             


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
    930                 935                 940                 


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
945                 950                 955                 960 


Pro Asp Ala Gly Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu 
                965                 970                 975     


His Phe Pro Ala Pro Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr 
            980                 985                 990         


Leu Ser His Arg Ala Gly Ser Ala  Ser Arg Thr Asp Asp  Asp Val Pro 
        995                 1000                 1005             


Ser Leu  His Ser Glu Pro Val  Ala Arg Ser Ser Ser  Ser Gln Gly 
    1010                 1015                 1020             


Ser Leu  Met Glu Gln Ile Ser  Ser Val Val Thr Arg  Phe Thr Ala 
    1025                 1030                 1035             


Asn Ile  Ser Glu Leu Asn Ser  Met Met Leu Ser Thr  Ala Ala Pro 
    1040                 1045                 1050             


Ser Pro  Gly Val Gly Ala Pro  Leu Cys Ser Ser Tyr  Leu Ile Pro 
    1055                 1060                 1065             


Lys Glu  Ile Gln Leu Pro Thr  Thr Met Thr Thr Phe  Ala Glu Ile 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Ile Glu  Val Thr Gly Gly Ala  Gln Pro Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gln Ala Ala Gly  Asp Ala Ala Arg Glu  Ser Pro Ala 
    1100                 1105                 1110             


Ala Gly  Pro Glu Ala Ala Ala  Ala Lys Pro Asp Leu  Glu Glu Leu 
    1115                 1120                 1125             


Val Ala  Leu Thr Pro Pro Ser  Pro Phe Arg Asp Ser  Val Asp Ser 
    1130                 1135                 1140             


Gly Ser  Thr Thr Pro Asn Ser  Pro Val Ser Glu Ser  Ala Leu Cys 
    1145                 1150                 1155             


Ile Pro  Ser Ser Pro Lys Tyr  Asp Thr Leu Ile Ile  Arg Asp Tyr 
    1160                 1165                 1170             


Thr Gln  Ser Ser Ser Ser Leu  
    1175                 1180 


<210>  4743
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM6__Homo_sapiens__NP_000834

<400>  4743

Met Ala Arg Pro Arg Arg Ala Arg Glu Pro Leu Leu Val Ala Leu Leu 
1               5                   10                  15      


Pro Leu Ala Trp Leu Ala Gln Ala Gly Leu Ala Arg Ala Ala Gly Ser 
            20                  25                  30          


Val Arg Leu Ala Gly Gly Leu Thr Leu Gly Gly Leu Phe Pro Val His 
        35                  40                  45              


Ala Arg Gly Ala Ala Gly Arg Ala Cys Gly Gln Leu Lys Lys Glu Gln 
    50                  55                  60                  


Gly Val His Arg Leu Glu Ala Met Leu Tyr Ala Leu Asp Arg Val Asn 
65                  70                  75                  80  


Ala Asp Pro Glu Leu Leu Pro Gly Val Arg Leu Gly Ala Arg Leu Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ala Leu Ser Phe 
            100                 105                 110         


Val Gln Ala Leu Ile Arg Gly Arg Gly Asp Gly Asp Glu Val Gly Val 
        115                 120                 125             


Arg Cys Pro Gly Gly Val Pro Pro Leu Arg Pro Ala Pro Pro Glu Arg 
    130                 135                 140                 


Val Val Ala Val Val Gly Ala Ser Ala Ser Ser Val Ser Ile Met Val 
145                 150                 155                 160 


Ala Asn Val Leu Arg Leu Phe Ala Ile Pro Gln Ile Ser Tyr Ala Ser 
                165                 170                 175     


Thr Ala Pro Glu Leu Ser Asp Ser Thr Arg Tyr Asp Phe Phe Ser Arg 
            180                 185                 190         


Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp Ile Val 
        195                 200                 205             


Arg Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu Gly Asn 
    210                 215                 220                 


Tyr Gly Glu Ser Gly Val Glu Ala Phe Val Gln Ile Ser Arg Glu Ala 
225                 230                 235                 240 


Gly Gly Val Cys Ile Ala Gln Ser Ile Lys Ile Pro Arg Glu Pro Lys 
                245                 250                 255     


Pro Gly Glu Phe Ser Lys Val Ile Arg Arg Leu Met Glu Thr Pro Asn 
            260                 265                 270         


Ala Arg Gly Ile Ile Ile Phe Ala Asn Glu Asp Asp Ile Arg Arg Val 
        275                 280                 285             


Leu Glu Ala Ala Arg Gln Ala Asn Leu Thr Gly His Phe Leu Trp Val 
    290                 295                 300                 


Gly Ser Asp Ser Trp Gly Ala Lys Thr Ser Pro Ile Leu Ser Leu Glu 
305                 310                 315                 320 


Asp Val Ala Val Gly Ala Ile Thr Ile Leu Pro Lys Arg Ala Ser Ile 
                325                 330                 335     


Asp Gly Phe Asp Gln Tyr Phe Met Thr Arg Ser Leu Glu Asn Asn Arg 
            340                 345                 350         


Arg Asn Ile Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Asn Cys Lys 
        355                 360                 365             


Leu Thr Ser Ser Gly Thr Gln Ser Asp Asp Ser Thr Arg Lys Cys Thr 
    370                 375                 380                 


Gly Glu Glu Arg Ile Gly Arg Asp Ser Thr Tyr Glu Gln Glu Gly Lys 
385                 390                 395                 400 


Val Gln Phe Val Ile Asp Ala Val Tyr Ala Ile Ala His Ala Leu His 
                405                 410                 415     


Ser Met His Gln Ala Leu Cys Pro Gly His Thr Gly Leu Cys Pro Ala 
            420                 425                 430         


Met Glu Pro Thr Asp Gly Arg Met Leu Leu Gln Tyr Ile Arg Ala Val 
        435                 440                 445             


Arg Phe Asn Gly Ser Ala Gly Thr Pro Val Met Phe Asn Glu Asn Gly 
    450                 455                 460                 


Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ala Thr Asn Gly 
465                 470                 475                 480 


Ser Ala Ser Ser Gly Gly Tyr Gln Ala Val Gly Gln Trp Ala Glu Thr 
                485                 490                 495     


Leu Arg Leu Asp Val Glu Ala Leu Gln Trp Ser Gly Asp Pro His Glu 
            500                 505                 510         


Val Pro Ser Ser Leu Cys Ser Leu Pro Cys Gly Pro Gly Glu Arg Lys 
        515                 520                 525             


Lys Met Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Ala Cys Asp 
    530                 535                 540                 


Gly Tyr Arg Phe Gln Val Asp Glu Phe Thr Cys Glu Ala Cys Pro Gly 
545                 550                 555                 560 


Asp Met Arg Pro Thr Pro Asn His Thr Gly Cys Arg Pro Thr Pro Val 
                565                 570                 575     


Val Arg Leu Ser Trp Ser Ser Pro Trp Ala Ala Pro Pro Leu Leu Leu 
            580                 585                 590         


Ala Val Leu Gly Ile Val Ala Thr Thr Thr Val Val Ala Thr Phe Val 
        595                 600                 605             


Arg Tyr Asn Asn Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser 
    610                 615                 620                 


Tyr Val Leu Leu Thr Gly Ile Phe Leu Ile Tyr Ala Ile Thr Phe Leu 
625                 630                 635                 640 


Met Val Ala Glu Pro Gly Ala Ala Val Cys Ala Ala Arg Arg Leu Phe 
                645                 650                 655     


Leu Gly Leu Gly Thr Thr Leu Ser Tyr Ser Ala Leu Leu Thr Lys Thr 
            660                 665                 670         


Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys Arg Ser Val Thr Pro 
        675                 680                 685             


Pro Pro Phe Ile Ser Pro Thr Ser Gln Leu Val Ile Thr Phe Ser Leu 
    690                 695                 700                 


Thr Ser Leu Gln Val Val Gly Met Ile Ala Trp Leu Gly Ala Arg Pro 
705                 710                 715                 720 


Pro His Ser Val Ile Asp Tyr Glu Glu Gln Arg Thr Val Asp Pro Glu 
                725                 730                 735     


Gln Ala Arg Gly Val Leu Lys Cys Asp Met Ser Asp Leu Ser Leu Ile 
            740                 745                 750         


Gly Cys Leu Gly Tyr Ser Leu Leu Leu Met Val Thr Cys Thr Val Tyr 
        755                 760                 765             


Ala Ile Lys Ala Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro 
    770                 775                 780                 


Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Val 
785                 790                 795                 800 


Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Ile Tyr Ile Gln 
                805                 810                 815     


Thr Thr Thr Leu Thr Val Ser Leu Ser Leu Ser Ala Ser Val Ser Leu 
            820                 825                 830         


Gly Met Leu Tyr Val Pro Lys Thr Tyr Val Ile Leu Phe His Pro Glu 
        835                 840                 845             


Gln Asn Val Gln Lys Arg Lys Arg Ser Leu Lys Ala Thr Ser Thr Val 
    850                 855                 860                 


Ala Ala Pro Pro Lys Gly Glu Asp Ala Glu Ala His Lys 
865                 870                 875         


<210>  4744
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM7__Homo_sapiens__NP_000835

<400>  4744

Met Val Gln Leu Arg Lys Leu Leu Arg Val Leu Thr Leu Met Lys Phe 
1               5                   10                  15      


Pro Cys Cys Val Leu Glu Val Leu Leu Cys Ala Leu Ala Ala Ala Ala 
            20                  25                  30          


Arg Gly Gln Glu Met Tyr Ala Pro His Ser Ile Arg Ile Glu Gly Asp 
        35                  40                  45              


Val Thr Leu Gly Gly Leu Phe Pro Val His Ala Lys Gly Pro Ser Gly 
    50                  55                  60                  


Val Pro Cys Gly Asp Ile Lys Arg Glu Asn Gly Ile His Arg Leu Glu 
65                  70                  75                  80  


Ala Met Leu Tyr Ala Leu Asp Gln Ile Asn Ser Asp Pro Asn Leu Leu 
                85                  90                  95      


Pro Asn Val Thr Leu Gly Ala Arg Ile Leu Asp Thr Cys Ser Arg Asp 
            100                 105                 110         


Thr Tyr Ala Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Gln 
        115                 120                 125             


Lys Asp Thr Ser Asp Val Arg Cys Thr Asn Gly Glu Pro Pro Val Phe 
    130                 135                 140                 


Val Lys Pro Glu Lys Val Val Gly Val Ile Gly Ala Ser Gly Ser Ser 
145                 150                 155                 160 


Val Ser Ile Met Val Ala Asn Ile Leu Arg Leu Phe Gln Ile Pro Gln 
                165                 170                 175     


Ile Ser Tyr Ala Ser Thr Ala Pro Glu Leu Ser Asp Asp Arg Arg Tyr 
            180                 185                 190         


Asp Phe Phe Ser Arg Val Val Pro Pro Asp Ser Phe Gln Ala Gln Ala 
        195                 200                 205             


Met Val Asp Ile Val Lys Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu 
    210                 215                 220                 


Ala Ser Glu Gly Ser Tyr Gly Glu Lys Gly Val Glu Ser Phe Thr Gln 
225                 230                 235                 240 


Ile Ser Lys Glu Ala Gly Gly Leu Cys Ile Ala Gln Ser Val Arg Ile 
                245                 250                 255     


Pro Gln Glu Arg Lys Asp Arg Thr Ile Asp Phe Asp Arg Ile Ile Lys 
            260                 265                 270         


Gln Leu Leu Asp Thr Pro Asn Ser Arg Ala Val Val Ile Phe Ala Asn 
        275                 280                 285             


Asp Glu Asp Ile Lys Gln Ile Leu Ala Ala Ala Lys Arg Ala Asp Gln 
    290                 295                 300                 


Val Gly His Phe Leu Trp Val Gly Ser Asp Ser Trp Gly Ser Lys Ile 
305                 310                 315                 320 


Asn Pro Leu His Gln His Glu Asp Ile Ala Glu Gly Ala Ile Thr Ile 
                325                 330                 335     


Gln Pro Lys Arg Ala Thr Val Glu Gly Phe Asp Ala Tyr Phe Thr Ser 
            340                 345                 350         


Arg Thr Leu Glu Asn Asn Arg Arg Asn Val Trp Phe Ala Glu Tyr Trp 
        355                 360                 365             


Glu Glu Asn Phe Asn Cys Lys Leu Thr Ile Ser Gly Ser Lys Lys Glu 
    370                 375                 380                 


Asp Thr Asp Arg Lys Cys Thr Gly Gln Glu Arg Ile Gly Lys Asp Ser 
385                 390                 395                 400 


Asn Tyr Glu Gln Glu Gly Lys Val Gln Phe Val Ile Asp Ala Val Tyr 
                405                 410                 415     


Ala Met Ala His Ala Leu His His Met Asn Lys Asp Leu Cys Ala Asp 
            420                 425                 430         


Tyr Arg Gly Val Cys Pro Glu Met Glu Gln Ala Gly Gly Lys Lys Leu 
        435                 440                 445             


Leu Lys Tyr Ile Arg Asn Val Asn Phe Asn Gly Ser Ala Gly Thr Pro 
    450                 455                 460                 


Val Met Phe Asn Lys Asn Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe 
465                 470                 475                 480 


Gln Tyr Gln Thr Thr Asn Thr Ser Asn Pro Gly Tyr Arg Leu Ile Gly 
                485                 490                 495     


Gln Trp Thr Asp Glu Leu Gln Leu Asn Ile Glu Asp Met Gln Trp Gly 
            500                 505                 510         


Lys Gly Val Arg Glu Ile Pro Ala Ser Val Cys Thr Leu Pro Cys Lys 
        515                 520                 525             


Pro Gly Gln Arg Lys Lys Thr Gln Lys Gly Thr Pro Cys Cys Trp Thr 
    530                 535                 540                 


Cys Glu Pro Cys Asp Gly Tyr Gln Tyr Gln Phe Asp Glu Met Thr Cys 
545                 550                 555                 560 


Gln His Cys Pro Tyr Asp Gln Arg Pro Asn Glu Asn Arg Thr Gly Cys 
                565                 570                 575     


Gln Asp Ile Pro Ile Ile Lys Leu Glu Trp His Ser Pro Trp Ala Val 
            580                 585                 590         


Ile Pro Val Phe Leu Ala Met Leu Gly Ile Ile Ala Thr Ile Phe Val 
        595                 600                 605             


Met Ala Thr Phe Ile Arg Tyr Asn Asp Thr Pro Ile Val Arg Ala Ser 
    610                 615                 620                 


Gly Arg Glu Leu Ser Tyr Val Leu Leu Thr Gly Ile Phe Leu Cys Tyr 
625                 630                 635                 640 


Ile Ile Thr Phe Leu Met Ile Ala Lys Pro Asp Val Ala Val Cys Ser 
                645                 650                 655     


Phe Arg Arg Val Phe Leu Gly Leu Gly Met Cys Ile Ser Tyr Ala Ala 
            660                 665                 670         


Leu Leu Thr Lys Thr Asn Arg Ile Tyr Arg Ile Phe Glu Gln Gly Lys 
        675                 680                 685             


Lys Ser Val Thr Ala Pro Arg Leu Ile Ser Pro Thr Ser Gln Leu Ala 
    690                 695                 700                 


Ile Thr Ser Ser Leu Ile Ser Val Gln Leu Leu Gly Val Phe Ile Trp 
705                 710                 715                 720 


Phe Gly Val Asp Pro Pro Asn Ile Ile Ile Asp Tyr Asp Glu His Lys 
                725                 730                 735     


Thr Met Asn Pro Glu Gln Ala Arg Gly Val Leu Lys Cys Asp Ile Thr 
            740                 745                 750         


Asp Leu Gln Ile Ile Cys Ser Leu Gly Tyr Ser Ile Leu Leu Met Val 
        755                 760                 765             


Thr Cys Thr Val Tyr Ala Ile Lys Thr Arg Gly Val Pro Glu Asn Phe 
    770                 775                 780                 


Asn Glu Ala Lys Pro Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Val 
785                 790                 795                 800 


Trp Leu Ala Phe Ile Pro Ile Phe Phe Gly Thr Ala Gln Ser Ala Glu 
                805                 810                 815     


Lys Leu Tyr Ile Gln Thr Thr Thr Leu Thr Ile Ser Met Asn Leu Ser 
            820                 825                 830         


Ala Ser Val Ala Leu Gly Met Leu Tyr Met Pro Lys Val Tyr Ile Ile 
        835                 840                 845             


Ile Phe His Pro Glu Leu Asn Val Gln Lys Arg Lys Arg Ser Phe Lys 
    850                 855                 860                 


Ala Val Val Thr Ala Ala Thr Met Ser Ser Arg Leu Ser His Lys Pro 
865                 870                 875                 880 


Ser Asp Arg Pro Asn Gly Glu Ala Lys Thr Glu Leu Cys Glu Asn Val 
                885                 890                 895     


Asp Pro Asn Ser Pro Ala Ala Lys Lys Lys Tyr Val Ser Tyr Asn Asn 
            900                 905                 910         


Leu Val Ile 
        915 


<210>  4745
<211>  908
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRM8__Homo_sapiens__XP_006716001

<400>  4745

Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Thr Ser Ser Thr 
                885                 890                 895     


Lys Thr Thr Tyr Ile Ser Tyr Ser Asn His Ser Ile 
            900                 905             


<210>  4746
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRN__Homo_sapiens__XP_005257310

<400>  4746

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  4747
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRPEL1__Homo_sapiens__NP_079472

<400>  4747

Met Ala Ala Gln Cys Val Arg Leu Ala Arg Arg Ser Leu Pro Ala Leu 
1               5                   10                  15      


Ala Leu Ser Leu Arg Pro Ser Pro Arg Leu Leu Cys Thr Ala Thr Lys 
            20                  25                  30          


Gln Lys Asn Ser Gly Gln Asn Leu Glu Glu Asp Met Gly Gln Ser Glu 
        35                  40                  45              


Gln Lys Ala Asp Pro Pro Ala Thr Glu Lys Thr Leu Leu Glu Glu Lys 
    50                  55                  60                  


Val Lys Leu Glu Glu Gln Leu Lys Glu Thr Val Glu Lys Tyr Lys Arg 
65                  70                  75                  80  


Ala Leu Ala Asp Thr Glu Asn Leu Arg Gln Arg Ser Gln Lys Leu Val 
                85                  90                  95      


Glu Glu Ala Lys Leu Tyr Gly Ile Gln Ala Phe Cys Lys Asp Leu Leu 
            100                 105                 110         


Glu Val Ala Asp Val Leu Glu Lys Ala Thr Gln Cys Val Pro Lys Glu 
        115                 120                 125             


Glu Ile Lys Asp Asp Asn Pro His Leu Lys Asn Leu Tyr Glu Gly Leu 
    130                 135                 140                 


Val Met Thr Glu Val Gln Ile Gln Lys Val Phe Thr Lys His Gly Leu 
145                 150                 155                 160 


Leu Lys Leu Asn Pro Val Gly Ala Lys Phe Asp Pro Tyr Glu His Glu 
                165                 170                 175     


Ala Leu Phe His Thr Pro Val Glu Gly Lys Glu Pro Gly Thr Val Ala 
            180                 185                 190         


Leu Val Ser Lys Val Gly Tyr Lys Leu His Gly Arg Thr Leu Arg Pro 
        195                 200                 205             


Ala Leu Val Gly Val Val Lys Glu Ala 
    210                 215         


<210>  4748
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRP__Homo_sapiens__NP_001012530

<400>  4748

Met Arg Gly Arg Glu Leu Pro Leu Val Leu Leu Ala Leu Val Leu Cys 
1               5                   10                  15      


Leu Ala Pro Arg Gly Arg Ala Val Pro Leu Pro Ala Gly Gly Gly Thr 
            20                  25                  30          


Val Leu Thr Lys Met Tyr Pro Arg Gly Asn His Trp Ala Val Gly His 
        35                  40                  45              


Leu Met Gly Lys Lys Ser Thr Gly Glu Ser Ser Ser Val Ser Glu Arg 
    50                  55                  60                  


Gly Ser Leu Lys Gln Gln Leu Arg Glu Tyr Ile Arg Trp Glu Glu Ala 
65                  70                  75                  80  


Ala Arg Asn Leu Leu Gly Leu Ile Glu Ala Lys Glu Asn Arg Asn His 
                85                  90                  95      


Gln Pro Pro Gln Pro Lys Ala Leu Gly Asn Gln Gln Pro Ser Trp Asp 
            100                 105                 110         


Ser Glu Asp Ser Ser Asn Phe Lys Asp Val Gly Ser Lys Gly Lys Gly 
        115                 120                 125             


Ser Gln Arg Glu Gly Arg Asn Pro Gln Leu Asn Gln Gln 
    130                 135                 140     


<210>  4749
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRPR__Homo_sapiens__NP_005305

<400>  4749

Met Ala Leu Asn Asp Cys Phe Leu Leu Asn Leu Glu Val Asp His Phe 
1               5                   10                  15      


Met His Cys Asn Ile Ser Ser His Ser Ala Asp Leu Pro Val Asn Asp 
            20                  25                  30          


Asp Trp Ser His Pro Gly Ile Leu Tyr Val Ile Pro Ala Val Tyr Gly 
        35                  40                  45              


Val Ile Ile Leu Ile Gly Leu Ile Gly Asn Ile Thr Leu Ile Lys Ile 
    50                  55                  60                  


Phe Cys Thr Val Lys Ser Met Arg Asn Val Pro Asn Leu Phe Ile Ser 
65                  70                  75                  80  


Ser Leu Ala Leu Gly Asp Leu Leu Leu Leu Ile Thr Cys Ala Pro Val 
                85                  90                  95      


Asp Ala Ser Arg Tyr Leu Ala Asp Arg Trp Leu Phe Gly Arg Ile Gly 
            100                 105                 110         


Cys Lys Leu Ile Pro Phe Ile Gln Leu Thr Ser Val Gly Val Ser Val 
        115                 120                 125             


Phe Thr Leu Thr Ala Leu Ser Ala Asp Arg Tyr Lys Ala Ile Val Arg 
    130                 135                 140                 


Pro Met Asp Ile Gln Ala Ser His Ala Leu Met Lys Ile Cys Leu Lys 
145                 150                 155                 160 


Ala Ala Phe Ile Trp Ile Ile Ser Met Leu Leu Ala Ile Pro Glu Ala 
                165                 170                 175     


Val Phe Ser Asp Leu His Pro Phe His Glu Glu Ser Thr Asn Gln Thr 
            180                 185                 190         


Phe Ile Ser Cys Ala Pro Tyr Pro His Ser Asn Glu Leu His Pro Lys 
        195                 200                 205             


Ile His Ser Met Ala Ser Phe Leu Val Phe Tyr Val Ile Pro Leu Ser 
    210                 215                 220                 


Ile Ile Ser Val Tyr Tyr Tyr Phe Ile Ala Lys Asn Leu Ile Gln Ser 
225                 230                 235                 240 


Ala Tyr Asn Leu Pro Val Glu Gly Asn Ile His Val Lys Lys Gln Ile 
                245                 250                 255     


Glu Ser Arg Lys Arg Leu Ala Lys Thr Val Leu Val Phe Val Gly Leu 
            260                 265                 270         


Phe Ala Phe Cys Trp Leu Pro Asn His Val Ile Tyr Leu Tyr Arg Ser 
        275                 280                 285             


Tyr His Tyr Ser Glu Val Asp Thr Ser Met Leu His Phe Val Thr Ser 
    290                 295                 300                 


Ile Cys Ala Arg Leu Leu Ala Phe Thr Asn Ser Cys Val Asn Pro Phe 
305                 310                 315                 320 


Ala Leu Tyr Leu Leu Ser Lys Ser Phe Arg Lys Gln Phe Asn Thr Gln 
                325                 330                 335     


Leu Leu Cys Cys Gln Pro Gly Leu Ile Ile Arg Ser His Ser Thr Gly 
            340                 345                 350         


Arg Ser Thr Thr Cys Met Thr Ser Leu Lys Ser Thr Asn Pro Ser Val 
        355                 360                 365             


Ala Thr Phe Ser Leu Ile Asn Gly Asn Ile Cys His Glu Arg Tyr Val 
    370                 375                 380                 


<210>  4750
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRSF1__Homo_sapiens__NP_001091947

<400>  4750

Met Glu Asp Val Leu Asn Phe Phe Ser Asp Cys Arg Ile Arg Asn Gly 
1               5                   10                  15      


Glu Asn Gly Ile His Phe Leu Leu Asn Arg Asp Gly Lys Arg Arg Gly 
            20                  25                  30          


Asp Ala Leu Ile Glu Met Glu Ser Glu Gln Asp Val Gln Lys Ala Leu 
        35                  40                  45              


Glu Lys His Arg Met Tyr Met Gly Gln Arg Tyr Val Glu Val Tyr Glu 
    50                  55                  60                  


Ile Asn Asn Glu Asp Val Asp Ala Leu Met Lys Ser Leu Gln Val Lys 
65                  70                  75                  80  


Ser Ser Pro Val Val Asn Asp Gly Val Val Arg Leu Arg Gly Leu Pro 
                85                  90                  95      


Tyr Ser Cys Asn Glu Lys Asp Ile Val Asp Phe Phe Ala Gly Leu Asn 
            100                 105                 110         


Ile Val Asp Ile Thr Phe Val Met Asp Tyr Arg Gly Arg Arg Lys Thr 
        115                 120                 125             


Gly Glu Ala Tyr Val Gln Phe Glu Glu Pro Glu Met Ala Asn Gln Ala 
    130                 135                 140                 


Leu Leu Lys His Arg Glu Glu Ile Gly Asn Arg Tyr Ile Glu Ile Phe 
145                 150                 155                 160 


Pro Ser Arg Arg Asn Glu Val Arg Thr His Val Gly Ser Tyr Lys Gly 
                165                 170                 175     


Lys Lys Ile Ala Ser Phe Pro Thr Ala Lys Tyr Ile Thr Glu Pro Glu 
            180                 185                 190         


Met Val Phe Glu Glu His Glu Val Asn Glu Asp Ile Gln Pro Met Thr 
        195                 200                 205             


Ala Phe Glu Ser Glu Lys Glu Ile Glu Leu Pro Lys Glu Val Pro Glu 
    210                 215                 220                 


Lys Leu Pro Glu Ala Ala Asp Phe Gly Thr Thr Ser Ser Leu His Phe 
225                 230                 235                 240 


Val His Met Arg Gly Leu Pro Phe Gln Ala Asn Ala Gln Asp Ile Ile 
                245                 250                 255     


Asn Phe Phe Ala Pro Leu Lys Pro Val Arg Ile Thr Met Glu Tyr Ser 
            260                 265                 270         


Ser Ser Gly Lys Ala Thr Gly Glu Ala Asp Val His Phe Glu Thr His 
        275                 280                 285             


Glu Asp Ala Val Ala Ala Met Leu Lys Asp Arg Ser His Val His His 
    290                 295                 300                 


Arg Tyr Ile Glu Leu Phe Leu Asn Ser Cys Pro Lys Gly Lys 
305                 310                 315             


<210>  4751
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRXCR1__Homo_sapiens__NP_001073945

<400>  4751

Met Leu Lys Arg Glu Met Lys Pro Glu Ser Asp Arg Pro Arg Lys Val 
1               5                   10                  15      


Arg Phe Arg Ile Ala Ser Ser His Ser Gly Arg Val Leu Lys Glu Val 
            20                  25                  30          


Tyr Glu Asp Gly Gln Pro Ser Gly Ser Leu Asp Ser Glu Cys Ala Ser 
        35                  40                  45              


Ile Cys Gly Ile Asp Gly Leu Gly Asp Ser Asp Gly Gln Gln Asn Gly 
    50                  55                  60                  


His Ile Glu Ser Glu Gly Asp Glu Asn Glu Asn Asp Gln Asp Ser Leu 
65                  70                  75                  80  


Leu Val Leu Ala Arg Ala Ala Ser Glu Lys Gly Phe Gly Thr Arg Arg 
                85                  90                  95      


Val Asn Ile Leu Ser Lys Asn Gly Thr Val Arg Gly Val Lys Tyr Lys 
            100                 105                 110         


Val Ser Ala Gly Gln Ala Leu Phe Asn Asn Leu Thr Lys Val Leu Gln 
        115                 120                 125             


Gln Pro Ser Thr Asp Leu Glu Phe Asp Arg Val Val Ile Tyr Thr Thr 
    130                 135                 140                 


Cys Leu Arg Val Val Arg Thr Thr Phe Glu Arg Cys Glu Leu Val Arg 
145                 150                 155                 160 


Lys Ile Phe Gln Asn His Arg Val Lys Phe Glu Glu Lys Asn Ile Ala 
                165                 170                 175     


Leu Asn Gly Glu Tyr Gly Lys Glu Leu Asp Glu Arg Cys Arg Arg Val 
            180                 185                 190         


Ser Glu Ala Pro Ser Leu Pro Val Val Phe Ile Asp Gly His Tyr Leu 
        195                 200                 205             


Gly Gly Ala Glu Lys Ile Leu Ser Met Asn Glu Ser Gly Glu Leu Gln 
    210                 215                 220                 


Asp Ile Leu Thr Lys Ile Glu Arg Val Gln His Pro His Glu Cys Pro 
225                 230                 235                 240 


Ser Cys Gly Gly Phe Gly Phe Leu Pro Cys Ser Val Cys His Gly Ser 
                245                 250                 255     


Lys Met Ser Met Phe Arg Asn Cys Phe Thr Asp Ser Phe Lys Ala Leu 
            260                 265                 270         


Lys Cys Thr Ala Cys Asn Glu Asn Gly Leu Gln Arg Cys Lys Asn Cys 
        275                 280                 285             


Ala Gly 
    290 


<210>  4752
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRXCR2__Homo_sapiens__XP_011535976

<400>  4752

Met Glu Asp Pro Glu Lys Lys Leu Asn Gln Lys Ser Asp Gly Lys Pro 
1               5                   10                  15      


Arg Lys Val Arg Phe Lys Ile Ser Ser Ser Tyr Ser Gly Arg Val Leu 
            20                  25                  30          


Lys Gln Val Phe Glu Asp Gly Gln Glu Leu Glu Ser Pro Lys Glu Glu 
        35                  40                  45              


Tyr Pro His Ser Phe Leu Gln Glu Ser Leu Glu Thr Met Asp Gly Val 
    50                  55                  60                  


Tyr Gly Ser Gly Glu Val Pro Arg Pro Gln Met Cys Ser Pro Lys Leu 
65                  70                  75                  80  


Thr Ala Gln Arg Ile Ser Val Phe Arg Glu Gly Asn Ala Tyr Thr Leu 
                85                  90                  95      


Ala Gly Gly Gln Pro Arg Phe Asn Asp Tyr Lys Ala Asn Asp His Lys 
            100                 105                 110         


Pro Leu Pro Ile Ile Asp Phe Gly Lys Ile Ile Ile Tyr Thr Asn Asn 
        115                 120                 125             


Leu Lys Ile Ile Arg Thr Pro Met Asp Lys Arg Asp Phe Val Arg Lys 
    130                 135                 140                 


Ile Leu Gln Lys Glu Glu Glu Ala Glu Glu Glu Ser Leu Met Asn Lys 
145                 150                 155                 160 


Glu Glu Ser Tyr Gly Gly Arg Asp Gln His Asp Arg Pro Leu Val Glu 
                165                 170                 175     


Ala Glu Ser Thr Leu Pro Gln Asn Arg Tyr Thr Gln Glu Gly Asp Ile 
            180                 185                 190         


Pro Glu Asp Ser Cys Phe His Cys Arg Gly Ser Gly Ser Ala Thr Cys 
        195                 200                 205             


Ser Leu Cys His Gly Ser Lys Phe Ser Met Leu Ala Asn Arg Phe Lys 
    210                 215                 220                 


Glu Ser Tyr Arg Ala Leu Arg Cys Pro Ala Cys Asn Glu Asn Gly Leu 
225                 230                 235                 240 


Gln Pro Cys Gln Ile Cys Asn Gln 
                245             


<210>  4753
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSC2__Homo_sapiens__NP_005306

<400>  4753

Met Ala Ala Ala Ala Gly Gly Ala Ala Ser Arg Arg Gly Ala Gly Arg 
1               5                   10                  15      


Pro Cys Pro Phe Ser Ile Glu His Ile Leu Ser Ser Leu Pro Glu Arg 
            20                  25                  30          


Ser Leu Pro Ala Arg Ala Ala Cys Pro Pro Gln Pro Ala Gly Arg Gln 
        35                  40                  45              


Ser Pro Ala Lys Pro Glu Glu Pro Gly Ala Pro Glu Ala Ala Pro Cys 
    50                  55                  60                  


Ala Cys Cys Cys Cys Cys Gly Pro Arg Ala Ala Pro Cys Gly Pro Pro 
65                  70                  75                  80  


Glu Ala Ala Ala Gly Leu Gly Ala Arg Leu Ala Trp Pro Leu Arg Leu 
                85                  90                  95      


Gly Pro Ala Val Pro Leu Ser Leu Gly Ala Pro Ala Gly Gly Ser Gly 
            100                 105                 110         


Ala Leu Pro Gly Ala Val Gly Pro Gly Ser Gln Arg Arg Thr Arg Arg 
        115                 120                 125             


His Arg Thr Ile Phe Ser Glu Glu Gln Leu Gln Ala Leu Glu Ala Leu 
    130                 135                 140                 


Phe Val Gln Asn Gln Tyr Pro Asp Val Ser Thr Arg Glu Arg Leu Ala 
145                 150                 155                 160 


Gly Arg Ile Arg Leu Arg Glu Glu Arg Val Glu Val Trp Phe Lys Asn 
                165                 170                 175     


Arg Arg Ala Lys Trp Arg His Gln Lys Arg Ala Ser Ala Ser Ala Arg 
            180                 185                 190         


Leu Leu Pro Gly Val Lys Lys Ser Pro Lys Gly Ser Cys 
        195                 200                 205 


<210>  4754
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSC__Homo_sapiens__NP_776248

<400>  4754

Met Pro Ala Ser Met Phe Ser Ile Asp Asn Ile Leu Ala Ala Arg Pro 
1               5                   10                  15      


Arg Cys Lys Asp Ser Val Leu Pro Val Ala His Ser Ala Ala Ala Pro 
            20                  25                  30          


Val Val Phe Pro Ala Leu His Gly Asp Ser Leu Tyr Gly Ala Ser Gly 
        35                  40                  45              


Gly Ala Ser Ser Asp Tyr Gly Ala Phe Tyr Pro Arg Pro Val Ala Pro 
    50                  55                  60                  


Gly Gly Ala Gly Leu Pro Ala Ala Val Ser Gly Ser Arg Leu Gly Tyr 
65                  70                  75                  80  


Asn Asn Tyr Phe Tyr Gly Gln Leu His Val Gln Ala Ala Pro Val Gly 
                85                  90                  95      


Pro Ala Cys Cys Gly Ala Val Pro Pro Leu Gly Ala Gln Gln Cys Ser 
            100                 105                 110         


Cys Val Pro Thr Pro Pro Gly Tyr Glu Gly Pro Gly Ser Val Leu Val 
        115                 120                 125             


Ser Pro Val Pro His Gln Met Leu Pro Tyr Met Asn Val Gly Thr Leu 
    130                 135                 140                 


Ser Arg Thr Glu Leu Gln Leu Leu Asn Gln Leu His Cys Arg Arg Lys 
145                 150                 155                 160 


Arg Arg His Arg Thr Ile Phe Thr Asp Glu Gln Leu Glu Ala Leu Glu 
                165                 170                 175     


Asn Leu Phe Gln Glu Thr Lys Tyr Pro Asp Val Gly Thr Arg Glu Gln 
            180                 185                 190         


Leu Ala Arg Lys Val His Leu Arg Glu Glu Lys Val Glu Val Trp Phe 
        195                 200                 205             


Lys Asn Arg Arg Ala Lys Trp Arg Arg Gln Lys Arg Ser Ser Ser Glu 
    210                 215                 220                 


Glu Ser Glu Asn Ala Glu Lys Trp Asn Lys Thr Ser Ser Ser Lys Ala 
225                 230                 235                 240 


Ser Pro Glu Lys Arg Glu Glu Glu Gly Lys Ser Asp Leu Asp Ser Asp 
                245                 250                 255     


Ser 
    


<210>  4755
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSDMA__Homo_sapiens__XP_006721895

<400>  4755

Met Thr Met Phe Glu Asn Val Thr Arg Ala Leu Ala Arg Gln Leu Asn 
1               5                   10                  15      


Pro Arg Gly Asp Leu Thr Pro Leu Asp Ser Leu Ile Asp Phe Lys Arg 
            20                  25                  30          


Phe His Pro Phe Cys Leu Val Leu Arg Lys Arg Lys Ser Thr Leu Phe 
        35                  40                  45              


Trp Gly Ala Arg Tyr Val Arg Thr Asp Tyr Thr Leu Leu Asp Val Leu 
    50                  55                  60                  


Glu Pro Gly Ser Ser Pro Ser Asp Pro Thr Asp Thr Gly Asn Phe Gly 
65                  70                  75                  80  


Phe Lys Asn Met Leu Asp Thr Arg Val Glu Gly Asp Val Asp Val Pro 
                85                  90                  95      


Lys Thr Val Lys Val Lys Gly Thr Ala Gly Leu Ser Gln Asn Ser Thr 
            100                 105                 110         


Leu Glu Val Gln Thr Leu Ser Val Ala Pro Lys Ala Leu Glu Thr Val 
        115                 120                 125             


Gln Glu Arg Lys Leu Ala Ala Asp His Pro Phe Leu Lys Glu Met Gln 
    130                 135                 140                 


Asp Gln Gly Glu Asn Leu Tyr Val Val Met Glu Val Val Glu Thr Val 
145                 150                 155                 160 


Gln Glu Val Thr Leu Glu Arg Ala Gly Lys Ala Glu Ala Cys Phe Ser 
                165                 170                 175     


Leu Pro Phe Phe Ala Pro Leu Gly Leu Gln Gly Ser Ile Asn His Lys 
            180                 185                 190         


Glu Ala Val Thr Ile Pro Lys Gly Cys Val Leu Ala Phe Arg Val Arg 
        195                 200                 205             


Gln Leu Met Val Lys Gly Lys Asp Glu Trp Asp Ile Pro His Ile Cys 
    210                 215                 220                 


Asn Asp Asn Met Gln Thr Phe Pro Pro Gly Glu Lys Ser Gly Glu Glu 
225                 230                 235                 240 


Lys Val Ile Leu Ile Gln Ala Ser Asp Val Gly Asp Val His Glu Gly 
                245                 250                 255     


Phe Arg Thr Leu Lys Glu Glu Val Gln Arg Glu Thr Gln Gln Val Glu 
            260                 265                 270         


Lys Leu Ser Arg Val Gly Gln Ser Ser Leu Leu Ser Ser Leu Ser Lys 
        275                 280                 285             


Leu Leu Gly Lys Lys Lys Glu Leu Gln Asp Leu Glu Leu Ala Leu Glu 
    290                 295                 300                 


Gly Ala Leu Asp Lys Gly His Glu Val Thr Leu Glu Ala Leu Pro Lys 
305                 310                 315                 320 


Asp Val Leu Leu Ser Lys Glu Ala Val Gly Ala Ile Leu Tyr Phe Val 
                325                 330                 335     


Gly Ala Leu Thr Glu Leu Ser Glu Ala Gln Gln Lys Leu Leu Val Lys 
            340                 345                 350         


Ser Met Glu Lys Lys Ile Leu Pro Val Gln Leu Lys Leu Val Glu Ser 
        355                 360                 365             


Thr Met Glu Gln Asn Phe Leu Leu Asp Lys Glu Gly Val Phe Pro Leu 
    370                 375                 380                 


Gln Pro Glu Leu Leu Ser Ser Leu Gly Asp Glu Glu Leu Thr Leu Thr 
385                 390                 395                 400 


Glu Ala Leu Val Gly Leu Ser Gly Leu Glu Val Gln Arg Ser Gly Pro 
                405                 410                 415     


Gln Tyr Met Trp Asp Pro Asp Thr Leu Pro Arg Leu Cys Ala Leu Tyr 
            420                 425                 430         


Ala Gly Leu Ser Leu Leu Gln Gln Leu Thr Lys Ala Ser 
        435                 440                 445 


<210>  4756
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSDMB__Homo_sapiens__XP_011523318

<400>  4756

Met Phe Ser Val Phe Glu Glu Ile Thr Arg Ile Val Val Lys Glu Met 
1               5                   10                  15      


Asp Ala Gly Gly Asp Met Ile Ala Val Arg Ser Leu Val Asp Ala Asp 
            20                  25                  30          


Arg Phe Arg Cys Phe His Leu Val Gly Glu Lys Arg Thr Phe Phe Gly 
        35                  40                  45              


Cys Arg His Tyr Thr Thr Gly Leu Thr Leu Met Asp Ile Leu Asp Thr 
    50                  55                  60                  


Asp Gly Asp Lys Trp Leu Asp Glu Leu Asp Ser Gly Leu Gln Gly Gln 
65                  70                  75                  80  


Lys Ala Glu Phe Gln Ile Leu Asp Asn Val Asp Ser Thr Gly Glu Leu 
                85                  90                  95      


Ile Val Arg Leu Pro Lys Glu Ile Thr Ile Ser Gly Ser Phe Gln Gly 
            100                 105                 110         


Phe His His Gln Lys Ile Lys Ile Ser Glu Asn Arg Ile Ser Gln Gln 
        115                 120                 125             


Tyr Leu Ala Thr Leu Glu Asn Arg Lys Leu Lys Arg Glu Leu Pro Phe 
    130                 135                 140                 


Ser Phe Arg Ser Ile Asn Thr Arg Glu Asn Leu Tyr Leu Val Thr Glu 
145                 150                 155                 160 


Thr Leu Glu Thr Val Lys Glu Glu Thr Leu Lys Ser Asp Arg Gln Tyr 
                165                 170                 175     


Lys Phe Trp Ser Gln Ile Ser Gln Gly His Leu Ser Tyr Lys His Lys 
            180                 185                 190         


Gly Gln Arg Glu Val Thr Ile Pro Pro Asn Arg Val Leu Ser Tyr Arg 
        195                 200                 205             


Val Lys Gln Leu Val Phe Pro Asn Lys Glu Thr Met Asn Ile His Phe 
    210                 215                 220                 


Arg Gly Lys Thr Lys Ser Phe Pro Glu Glu Lys Asp Gly Ala Ser Ser 
225                 230                 235                 240 


Cys Leu Gly Lys Ser Leu Gly Ser Glu Asp Ser Arg Asn Met Lys Glu 
                245                 250                 255     


Lys Leu Glu Asp Met Glu Ser Val Leu Lys Asp Leu Thr Glu Glu Lys 
            260                 265                 270         


Arg Lys Asp Val Leu Asn Ser Leu Ala Lys Cys Leu Gly Lys Glu Asp 
        275                 280                 285             


Ile Arg Gln Asp Leu Glu Gln Arg Val Ser Glu Val Leu Ile Ser Gly 
    290                 295                 300                 


Glu Leu His Met Glu Asp Pro Asp Lys Pro Leu Leu Ser Ser Leu Phe 
305                 310                 315                 320 


Asn Ala Ala Gly Val Leu Val Glu Ala Arg Ala Lys Ala Ile Leu Asp 
                325                 330                 335     


Phe Leu Asp Ala Leu Leu Glu Leu Ser Glu Glu Gln Gln Phe Val Ala 
            340                 345                 350         


Glu Ala Leu Glu Lys Gly Thr Leu Pro Leu Leu Lys Asp Gln Val Lys 
        355                 360                 365             


Ser Val Met Glu Gln Asn Trp Asp Glu Leu Ala Ser Ser Pro Pro Asp 
    370                 375                 380                 


Met Asp Tyr Asp Pro Glu Ala Arg Ile Leu Cys Ala Leu Tyr Val Val 
385                 390                 395                 400 


Val Ser Ile Leu Leu Glu Leu Ala Glu Gly Pro Thr Ser Val Ser Ser 
                405                 410                 415     


<210>  4757
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSDMC__Homo_sapiens__NP_113603

<400>  4757

Met Pro Ser Met Leu Glu Arg Ile Ser Lys Asn Leu Val Lys Glu Ile 
1               5                   10                  15      


Gly Ser Lys Asp Leu Thr Pro Val Lys Tyr Leu Leu Ser Ala Thr Lys 
            20                  25                  30          


Leu Arg Gln Phe Val Ile Leu Arg Lys Lys Lys Asp Ser Arg Ser Ser 
        35                  40                  45              


Phe Trp Glu Gln Ser Asp Tyr Val Pro Val Glu Phe Ser Leu Asn Asp 
    50                  55                  60                  


Ile Leu Glu Pro Ser Ser Ser Val Leu Glu Thr Val Val Thr Gly Pro 
65                  70                  75                  80  


Phe His Phe Ser Asp Ile Met Ile Gln Lys His Lys Ala Asp Met Gly 
                85                  90                  95      


Val Asn Val Gly Ile Glu Val Ser Val Ser Gly Glu Ala Ser Val Asp 
            100                 105                 110         


His Gly Cys Ser Leu Glu Phe Gln Ile Val Thr Ile Pro Ser Pro Asn 
        115                 120                 125             


Leu Glu Asp Phe Gln Lys Arg Lys Leu Leu Asp Pro Glu Pro Ser Phe 
    130                 135                 140                 


Leu Lys Glu Cys Arg Arg Arg Gly Asp Asn Leu Tyr Val Val Thr Glu 
145                 150                 155                 160 


Ala Val Glu Leu Ile Asn Asn Thr Val Leu Tyr Asp Ser Ser Ser Val 
                165                 170                 175     


Asn Ile Leu Gly Lys Ile Ala Leu Trp Ile Thr Tyr Gly Lys Gly Gln 
            180                 185                 190         


Gly Gln Gly Glu Ser Leu Arg Val Lys Lys Lys Ala Leu Thr Leu Gln 
        195                 200                 205             


Lys Gly Met Val Met Ala Tyr Lys Arg Lys Gln Leu Val Ile Lys Glu 
    210                 215                 220                 


Lys Ala Ile Leu Ile Ser Asp Asp Asp Glu Gln Arg Thr Phe Gln Asp 
225                 230                 235                 240 


Glu Tyr Glu Ile Ser Glu Met Val Gly Tyr Cys Ala Ala Arg Ser Glu 
                245                 250                 255     


Gly Leu Leu Pro Ser Phe His Thr Ile Ser Pro Thr Leu Phe Asn Ala 
            260                 265                 270         


Ser Ser Asn Asp Met Lys Leu Lys Pro Glu Leu Phe Leu Thr Gln Gln 
        275                 280                 285             


Phe Leu Ser Gly His Leu Pro Lys Tyr Glu Gln Val His Ile Leu Pro 
    290                 295                 300                 


Val Gly Arg Ile Glu Glu Pro Phe Trp Gln Asn Phe Lys His Leu Gln 
305                 310                 315                 320 


Glu Glu Val Phe Gln Lys Ile Lys Thr Leu Ala Gln Leu Ser Lys Asp 
                325                 330                 335     


Val Gln Asp Val Met Phe Tyr Ser Ile Leu Ala Met Leu Arg Asp Arg 
            340                 345                 350         


Gly Ala Leu Gln Asp Leu Met Asn Met Leu Glu Leu Asp Ser Ser Gly 
        355                 360                 365             


His Leu Asp Gly Pro Gly Gly Ala Ile Leu Lys Lys Leu Gln Gln Asp 
    370                 375                 380                 


Ser Asn His Ala Trp Phe Asn Pro Lys Asp Pro Ile Leu Tyr Leu Leu 
385                 390                 395                 400 


Glu Ala Ile Met Val Leu Ser Asp Phe Gln His Asp Leu Leu Ala Cys 
                405                 410                 415     


Ser Met Glu Lys Arg Ile Leu Leu Gln Gln Gln Glu Leu Val Arg Ser 
            420                 425                 430         


Ile Leu Glu Pro Asn Phe Arg Tyr Pro Trp Ser Ile Pro Phe Thr Leu 
        435                 440                 445             


Lys Pro Glu Leu Leu Ala Pro Leu Gln Ser Glu Gly Leu Ala Ile Thr 
    450                 455                 460                 


Tyr Gly Leu Leu Glu Glu Cys Gly Leu Arg Met Glu Leu Asp Asn Pro 
465                 470                 475                 480 


Arg Ser Thr Trp Asp Val Glu Ala Lys Met Pro Leu Ser Ala Leu Tyr 
                485                 490                 495     


Gly Thr Leu Ser Leu Leu Gln Gln Leu Ala Glu Ala 
            500                 505             


<210>  4758
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSDMD__Homo_sapiens__NP_079012

<400>  4758

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         


Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln 
        275                 280                 285             


Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu 
    290                 295                 300                 


Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu 
305                 310                 315                 320 


Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly 
                325                 330                 335     


Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val 
            340                 345                 350         


Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala 
        355                 360                 365             


Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr 
    370                 375                 380                 


Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly 
385                 390                 395                 400 


Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln 
                405                 410                 415     


Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp 
            420                 425                 430         


Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu 
        435                 440                 445             


Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly 
    450                 455                 460                 


Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Gln Glu Pro His 
                


<210>  4759
<211>  1113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSE1__Homo_sapiens__NP_001127945

<400>  4759

Met Gly Pro Ile Ile Val Pro Pro Gly Gly His Ser Val Pro Ser Thr 
1               5                   10                  15      


Pro Pro Val Val Thr Ile Ala Pro Thr Lys Thr Val Asn Gly Val Trp 
            20                  25                  30          


Arg Ser Glu Ser Arg Gln Asp Ala Gly Ser Arg Ser Ser Ser Gly Gly 
        35                  40                  45              


Arg Glu Arg Leu Ile Val Glu Pro Pro Leu Pro Gln Glu Lys Ala Gly 
    50                  55                  60                  


Gly Pro Ala Ile Pro Ser His Leu Leu Ser Thr Pro Tyr Pro Phe Gly 
65                  70                  75                  80  


Leu Ser Pro Ser Ser Val Val Gln Asp Ser Arg Phe Pro Pro Leu Asn 
                85                  90                  95      


Leu Gln Arg Pro Val His His Val Val Pro Pro Ser Thr Val Thr Glu 
            100                 105                 110         


Asp Tyr Leu Arg Ser Phe Arg Pro Tyr His Thr Thr Asp Asp Leu Arg 
        115                 120                 125             


Met Ser Ser Leu Pro Pro Leu Gly Leu Asp Pro Ala Thr Ala Ala Ala 
    130                 135                 140                 


Tyr Tyr His Pro Ser Tyr Leu Ala Pro His Pro Phe Pro His Pro Ala 
145                 150                 155                 160 


Phe Arg Met Asp Asp Ser Tyr Cys Leu Ser Ala Leu Arg Ser Pro Phe 
                165                 170                 175     


Tyr Pro Ile Pro Thr Pro Gly Ser Leu Pro Pro Leu His Pro Ser Ala 
            180                 185                 190         


Met His Leu His Leu Ser Gly Val Arg Tyr Pro Pro Glu Leu Ser His 
        195                 200                 205             


Ser Ser Leu Ala Ala Leu His Ser Glu Arg Met Ser Gly Leu Ser Ala 
    210                 215                 220                 


Glu Arg Leu Gln Met Asp Glu Glu Leu Arg Arg Glu Arg Glu Arg Glu 
225                 230                 235                 240 


Arg Glu Arg Glu Arg Glu Arg Glu Ala Asp Arg Glu Arg Glu Lys Glu 
                245                 250                 255     


Arg Glu Arg Glu Arg Glu Lys Glu Arg Glu Gln Glu Lys Glu Arg Glu 
            260                 265                 270         


Arg Glu Lys Glu Arg Glu Arg Glu Leu Glu Arg Gln Arg Glu Gln Arg 
        275                 280                 285             


Ala Arg Glu Lys Glu Leu Leu Ala Ala Lys Ala Leu Glu Pro Ser Phe 
    290                 295                 300                 


Leu Pro Val Ala Glu Leu His Gly Leu Arg Gly His Ala Thr Glu Glu 
305                 310                 315                 320 


Arg Gly Lys Pro Ser Glu Gln Leu Thr Pro Thr Arg Ala Glu Lys Leu 
                325                 330                 335     


Lys Asp Ala Gly Leu Gln Ala Pro Lys Pro Val Gln His Pro Leu His 
            340                 345                 350         


Pro Val Pro Thr Pro His His Thr Val Pro Ser Leu Ile Ser Asn His 
        355                 360                 365             


Gly Ile Phe Ser Leu Pro Ser Ser Ser Ala Ala Thr Ala Leu Leu Ile 
    370                 375                 380                 


Gln Arg Thr Asn Glu Glu Glu Lys Trp Leu Ala Arg Gln Arg Arg Leu 
385                 390                 395                 400 


Arg Gln Glu Lys Glu Asp Arg Gln Ser Gln Val Ser Glu Phe Arg Gln 
                405                 410                 415     


Gln Val Leu Glu Gln His Leu Asp Met Gly Arg Pro Pro Val Pro Ala 
            420                 425                 430         


Glu Ala Glu His Arg Pro Glu Ser Thr Thr Arg Pro Gly Pro Asn Arg 
        435                 440                 445             


His Glu Pro Gly Gly Arg Asp Pro Pro Gln His Phe Gly Gly Pro Pro 
    450                 455                 460                 


Pro Leu Ile Ser Pro Lys Pro Gln Leu His Ala Ala Pro Thr Ala Leu 
465                 470                 475                 480 


Trp Asn Pro Val Ser Leu Met Asp Asn Thr Leu Glu Thr Arg Arg Ala 
                485                 490                 495     


Glu Ser His Ser Leu His Ser His Pro Ala Ala Phe Glu Pro Ser Arg 
            500                 505                 510         


Gln Ala Ala Val Pro Leu Val Lys Val Glu Arg Val Phe Cys Pro Glu 
        515                 520                 525             


Lys Ala Glu Glu Gly Pro Arg Lys Arg Glu Pro Ala Pro Leu Asp Lys 
    530                 535                 540                 


Tyr Gln Pro Pro Pro Pro Pro Pro Arg Glu Gly Gly Ser Leu Glu His 
545                 550                 555                 560 


Gln Pro Phe Leu Pro Gly Pro Gly Pro Phe Leu Ala Glu Leu Glu Lys 
                565                 570                 575     


Ser Thr Gln Thr Ile Leu Gly Gln Gln Arg Ala Ser Leu Pro Gln Ala 
            580                 585                 590         


Ala Thr Phe Gly Glu Leu Ser Gly Pro Leu Lys Pro Gly Ser Pro Tyr 
        595                 600                 605             


Arg Pro Pro Val Pro Arg Ala Pro Asp Pro Ala Tyr Ile Tyr Asp Glu 
    610                 615                 620                 


Phe Leu Gln Gln Arg Arg Arg Leu Val Ser Lys Leu Asp Leu Glu Glu 
625                 630                 635                 640 


Arg Arg Arg Arg Glu Ala Gln Glu Lys Gly Tyr Tyr Tyr Asp Leu Asp 
                645                 650                 655     


Asp Ser Tyr Asp Glu Ser Asp Glu Glu Glu Val Arg Ala His Leu Arg 
            660                 665                 670         


Cys Val Ala Glu Gln Pro Pro Leu Lys Leu Asp Thr Ser Ser Glu Lys 
        675                 680                 685             


Leu Glu Phe Leu Gln Leu Phe Gly Leu Thr Thr Gln Gln Gln Lys Glu 
    690                 695                 700                 


Glu Leu Val Ala Gln Lys Arg Arg Lys Arg Arg Arg Met Leu Arg Glu 
705                 710                 715                 720 


Arg Ser Pro Ser Pro Pro Thr Ile Gln Ser Lys Arg Gln Thr Pro Ser 
                725                 730                 735     


Pro Arg Leu Ala Leu Ser Thr Arg Tyr Ser Pro Asp Glu Met Asn Asn 
            740                 745                 750         


Ser Pro Asn Phe Glu Glu Lys Lys Lys Phe Leu Thr Ile Phe Asn Leu 
        755                 760                 765             


Thr His Ile Ser Ala Glu Lys Arg Lys Asp Lys Glu Arg Leu Val Glu 
    770                 775                 780                 


Met Leu Arg Ala Met Lys Gln Lys Ala Leu Ser Ala Ala Val Ala Asp 
785                 790                 795                 800 


Ser Leu Thr Asn Ser Pro Arg Asp Ser Pro Ala Val Ser Leu Ser Glu 
                805                 810                 815     


Pro Ala Thr Gln Gln Ala Ser Leu Asp Val Glu Lys Pro Val Gly Val 
            820                 825                 830         


Ala Ala Ser Leu Ser Asp Ile Pro Lys Ala Ala Glu Pro Gly Lys Leu 
        835                 840                 845             


Glu Gln Val Arg Pro Gln Glu Leu Ser Arg Val Gln Glu Leu Ala Pro 
    850                 855                 860                 


Ala Ser Gly Glu Lys Ala Arg Leu Ser Glu Ala Pro Gly Gly Lys Lys 
865                 870                 875                 880 


Ser Leu Ser Met Leu His Tyr Ile Arg Gly Ala Ala Pro Lys Asp Ile 
                885                 890                 895     


Pro Val Pro Leu Ser His Ser Thr Asn Gly Lys Ser Lys Pro Trp Glu 
            900                 905                 910         


Pro Phe Val Ala Glu Glu Phe Ala His Gln Phe His Glu Ser Val Leu 
        915                 920                 925             


Gln Ser Thr Gln Lys Ala Leu Gln Lys His Lys Gly Ser Val Ala Val 
    930                 935                 940                 


Leu Ser Ala Glu Gln Asn His Lys Val Asp Thr Ser Val His Tyr Asn 
945                 950                 955                 960 


Ile Pro Glu Leu Gln Ser Ser Ser Arg Ala Pro Pro Pro Gln His Asn 
                965                 970                 975     


Gly Gln Gln Glu Pro Pro Thr Ala Arg Lys Gly Pro Pro Thr Gln Glu 
            980                 985                 990         


Leu Asp Arg Asp Ser Glu Glu Glu  Glu Glu Glu Asp Asp  Glu Asp Gly 
        995                 1000                 1005             


Glu Asp  Glu Glu Glu Val Pro  Lys Arg Lys Trp Gln  Gly Ile Glu 
    1010                 1015                 1020             


Ala Val  Phe Glu Ala Tyr Gln  Glu His Ile Glu Glu  Gln Asn Leu 
    1025                 1030                 1035             


Glu Arg  Gln Val Leu Gln Thr  Gln Cys Arg Arg Leu  Glu Ala Arg 
    1040                 1045                 1050             


His Tyr  Ser Leu Ser Leu Thr  Ala Glu Gln Leu Ser  His Ser Val 
    1055                 1060                 1065             


Ala Glu  Leu Arg Ser Gln Lys  Gln Lys Met Val Ser  Glu Arg Glu 
    1070                 1075                 1080             


Arg Leu  Gln Ala Glu Leu Asp  His Leu Arg Lys Cys  Leu Ala Leu 
    1085                 1090                 1095             


Pro Ala  Met His Trp Pro Arg  Gly Tyr Leu Lys Gly  Tyr Pro Arg 
    1100                 1105                 1110             


<210>  4760
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG1L__Homo_sapiens__NP_001103233

<400>  4760

Met Lys Thr Ser Arg Arg Gly Arg Ala Leu Leu Ala Val Ala Leu Asn 
1               5                   10                  15      


Leu Leu Ala Leu Leu Phe Ala Thr Thr Ala Phe Leu Thr Thr His Trp 
            20                  25                  30          


Cys Gln Gly Thr Gln Arg Val Pro Lys Pro Gly Cys Gly Gln Gly Gly 
        35                  40                  45              


Arg Ala Asn Cys Pro Asn Ser Gly Ala Asn Ala Thr Ala Asn Gly Thr 
    50                  55                  60                  


Ala Ala Pro Ala Ala Ala Ala Ala Ala Ala Thr Ala Ser Gly Asn Gly 
65                  70                  75                  80  


Pro Pro Gly Gly Ala Leu Tyr Ser Trp Glu Thr Gly Asp Asp Arg Phe 
                85                  90                  95      


Leu Phe Arg Asn Phe His Thr Gly Ile Trp Tyr Ser Cys Glu Glu Glu 
            100                 105                 110         


Leu Ser Gly Leu Gly Glu Lys Cys Arg Ser Phe Ile Asp Leu Ala Pro 
        115                 120                 125             


Ala Ser Glu Lys Gly Val Leu Trp Leu Ser Val Val Ser Glu Val Leu 
    130                 135                 140                 


Tyr Ile Leu Leu Leu Val Val Gly Phe Ser Leu Met Cys Leu Glu Leu 
145                 150                 155                 160 


Phe His Ser Ser Asn Val Ile Asp Gly Leu Lys Leu Asn Ala Phe Ala 
                165                 170                 175     


Ala Val Phe Thr Val Leu Ser Gly Leu Leu Gly Met Val Ala His Met 
            180                 185                 190         


Met Tyr Thr Gln Val Phe Gln Val Thr Val Ser Leu Gly Pro Glu Asp 
        195                 200                 205             


Trp Arg Pro His Ser Trp Asp Tyr Gly Trp Ser Phe Cys Leu Ala Trp 
    210                 215                 220                 


Gly Ser Phe Thr Cys Cys Met Ala Ala Ser Val Thr Thr Leu Asn Ser 
225                 230                 235                 240 


Tyr Thr Lys Thr Val Ile Glu Phe Arg His Lys Arg Lys Val Phe Glu 
                245                 250                 255     


Gln Gly Tyr Arg Glu Glu Pro Thr Phe Ile Asp Pro Glu Ala Ile Lys 
            260                 265                 270         


Tyr Phe Arg Glu Arg Met Glu Lys Arg Asp Gly Ser Glu Glu Asp Phe 
        275                 280                 285             


His Leu Asp Cys Arg His Glu Arg Tyr Pro Ala Arg His Gln Pro His 
    290                 295                 300                 


Met Ala Asp Ser Trp Pro Arg Ser Ser Ala Gln Glu Ala Pro Glu Leu 
305                 310                 315                 320 


Asn Arg Gln Cys Trp Val Leu Gly His Trp Val 
                325                 330     


<210>  4761
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSK3A__Homo_sapiens__NP_063937

<400>  4761

Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg 
1               5                   10                  15      


Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly 
        35                  40                  45              


Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser 
    50                  55                  60                  


Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp 
                85                  90                  95      


Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu 
            100                 105                 110         


Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly 
        115                 120                 125             


Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu 
    130                 135                 140                 


Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu 
145                 150                 155                 160 


Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg 
                165                 170                 175     


Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn 
            180                 185                 190         


Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His 
        195                 200                 205             


Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr 
    210                 215                 220                 


Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val 
225                 230                 235                 240 


Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr 
                245                 250                 255     


Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg 
            260                 265                 270         


Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro 
        275                 280                 285             


Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp 
    290                 295                 300                 


Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe 
305                 310                 315                 320 


Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu 
                325                 330                 335     


Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr 
            340                 345                 350         


Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe 
        355                 360                 365             


Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu 
    370                 375                 380                 


Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His 
385                 390                 395                 400 


Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn 
                405                 410                 415     


Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile 
            420                 425                 430         


Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro 
        435                 440                 445             


Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr 
    450                 455                 460                 


Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr 
465                 470                 475                 480 


Asn Ser Ser 
            


<210>  4762
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSK3B__Homo_sapiens__NP_001139628

<400>  4762

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  4763
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSN__Homo_sapiens__NP_000168

<400>  4763

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  4764
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSPT1__Homo_sapiens__NP_001123478

<400>  4764

Met Asp Pro Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Ser Ser Asp Ser Ala Pro Asp Cys Trp Asp 
            20                  25                  30          


Gln Ala Asp Met Glu Ala Pro Gly Pro Gly Pro Cys Gly Gly Gly Gly 
        35                  40                  45              


Ser Leu Ala Ala Ala Ala Glu Ala Gln Arg Glu Asn Leu Ser Ala Ala 
    50                  55                  60                  


Phe Ser Arg Gln Leu Asn Val Asn Ala Lys Pro Phe Val Pro Asn Val 
65                  70                  75                  80  


His Ala Ala Glu Phe Val Pro Ser Phe Leu Arg Gly Pro Ala Ala Pro 
                85                  90                  95      


Pro Pro Pro Ala Gly Gly Ala Ala Asn Asn His Gly Ala Gly Ser Gly 
            100                 105                 110         


Ala Gly Gly Arg Ala Ala Pro Val Glu Ser Ser Gln Glu Glu Gln Ser 
        115                 120                 125             


Leu Cys Glu Gly Ser Asn Ser Ala Val Ser Met Glu Leu Ser Glu Pro 
    130                 135                 140                 


Ile Glu Asn Gly Glu Thr Glu Met Ser Pro Glu Glu Ser Trp Glu His 
145                 150                 155                 160 


Lys Glu Glu Ile Ser Glu Ala Glu Pro Gly Gly Gly Ser Leu Gly Asp 
                165                 170                 175     


Gly Arg Pro Pro Glu Glu Ser Ala His Glu Met Met Glu Glu Glu Glu 
            180                 185                 190         


Glu Ile Pro Lys Pro Lys Ser Val Val Ala Pro Pro Gly Ala Pro Lys 
        195                 200                 205             


Lys Glu His Val Asn Val Val Phe Ile Gly His Val Asp Ala Gly Lys 
    210                 215                 220                 


Ser Thr Ile Gly Gly Gln Ile Met Tyr Leu Thr Gly Met Val Asp Lys 
225                 230                 235                 240 


Arg Thr Leu Glu Lys Tyr Glu Arg Glu Ala Lys Glu Lys Asn Arg Glu 
                245                 250                 255     


Thr Trp Tyr Leu Ser Trp Ala Leu Asp Thr Asn Gln Glu Glu Arg Asp 
            260                 265                 270         


Lys Gly Lys Thr Val Glu Val Gly Arg Ala Tyr Phe Glu Thr Glu Lys 
        275                 280                 285             


Lys His Phe Thr Ile Leu Asp Ala Pro Gly His Lys Ser Phe Val Pro 
    290                 295                 300                 


Asn Met Ile Gly Gly Ala Ser Gln Ala Asp Leu Ala Val Leu Val Ile 
305                 310                 315                 320 


Ser Ala Arg Lys Gly Glu Phe Glu Thr Gly Phe Glu Lys Gly Gly Gln 
                325                 330                 335     


Thr Arg Glu His Ala Met Leu Ala Lys Thr Ala Gly Val Lys His Leu 
            340                 345                 350         


Ile Val Leu Ile Asn Lys Met Asp Asp Pro Thr Val Asn Trp Ser Asn 
        355                 360                 365             


Glu Arg Tyr Glu Glu Cys Lys Glu Lys Leu Val Pro Phe Leu Lys Lys 
    370                 375                 380                 


Val Gly Phe Asn Pro Lys Lys Asp Ile His Phe Met Pro Cys Ser Gly 
385                 390                 395                 400 


Leu Thr Gly Ala Asn Leu Lys Glu Gln Ser Asp Phe Cys Pro Trp Tyr 
                405                 410                 415     


Ile Gly Leu Pro Phe Ile Pro Tyr Leu Asp Asn Leu Pro Asn Phe Asn 
            420                 425                 430         


Arg Ser Val Asp Gly Pro Ile Arg Leu Pro Ile Val Asp Lys Tyr Lys 
        435                 440                 445             


Asp Met Gly Thr Val Val Leu Gly Lys Leu Glu Ser Gly Ser Ile Cys 
    450                 455                 460                 


Lys Gly Gln Gln Leu Val Met Met Pro Asn Lys His Asn Val Glu Val 
465                 470                 475                 480 


Leu Gly Ile Leu Ser Asp Asp Val Glu Thr Asp Thr Val Ala Pro Gly 
                485                 490                 495     


Glu Asn Leu Lys Ile Arg Leu Lys Gly Ile Glu Glu Glu Glu Ile Leu 
            500                 505                 510         


Pro Gly Phe Ile Leu Cys Asp Pro Asn Asn Leu Cys His Ser Gly Arg 
        515                 520                 525             


Thr Phe Asp Ala Gln Ile Val Ile Ile Glu His Lys Ser Ile Ile Cys 
    530                 535                 540                 


Pro Gly Tyr Asn Ala Val Leu His Ile His Thr Cys Ile Glu Glu Val 
545                 550                 555                 560 


Glu Ile Thr Ala Leu Ile Cys Leu Val Asp Lys Lys Ser Gly Glu Lys 
                565                 570                 575     


Ser Lys Thr Arg Pro Arg Phe Val Lys Gln Asp Gln Val Cys Ile Ala 
            580                 585                 590         


Arg Leu Arg Thr Ala Gly Thr Ile Cys Leu Glu Thr Phe Lys Asp Phe 
        595                 600                 605             


Pro Gln Met Gly Arg Phe Thr Leu Arg Asp Glu Gly Lys Thr Ile Ala 
    610                 615                 620                 


Ile Gly Lys Val Leu Lys Leu Val Pro Glu Lys Asp 
625                 630                 635     


<210>  4765
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSPT2__Homo_sapiens__NP_060564

<400>  4765

Met Asp Ser Gly Ser Ser Ser Ser Asp Ser Ala Pro Asp Cys Trp Asp 
1               5                   10                  15      


Gln Val Asp Met Glu Ser Pro Gly Ser Ala Pro Ser Gly Asp Gly Val 
            20                  25                  30          


Ser Ser Ala Val Ala Glu Ala Gln Arg Glu Pro Leu Ser Ser Ala Phe 
        35                  40                  45              


Ser Arg Lys Leu Asn Val Asn Ala Lys Pro Phe Val Pro Asn Val His 
    50                  55                  60                  


Ala Ala Glu Phe Val Pro Ser Phe Leu Arg Gly Pro Thr Gln Pro Pro 
65                  70                  75                  80  


Thr Leu Pro Ala Gly Ser Gly Ser Asn Asp Glu Thr Cys Thr Gly Ala 
                85                  90                  95      


Gly Tyr Pro Gln Gly Lys Arg Met Gly Arg Gly Ala Pro Val Glu Pro 
            100                 105                 110         


Ser Arg Glu Glu Pro Leu Val Ser Leu Glu Gly Ser Asn Ser Ala Val 
        115                 120                 125             


Thr Met Glu Leu Ser Glu Pro Val Val Glu Asn Gly Glu Val Glu Met 
    130                 135                 140                 


Ala Leu Glu Glu Ser Trp Glu His Ser Lys Glu Val Ser Glu Ala Glu 
145                 150                 155                 160 


Pro Gly Gly Gly Ser Ser Gly Asp Ser Gly Pro Pro Glu Glu Ser Gly 
                165                 170                 175     


Gln Glu Met Met Glu Glu Lys Glu Glu Ile Arg Lys Ser Lys Ser Val 
            180                 185                 190         


Ile Val Pro Ser Gly Ala Pro Lys Lys Glu His Val Asn Val Val Phe 
        195                 200                 205             


Ile Gly His Val Asp Ala Gly Lys Ser Thr Ile Gly Gly Gln Ile Met 
    210                 215                 220                 


Phe Leu Thr Gly Met Val Asp Lys Arg Thr Leu Glu Lys Tyr Glu Arg 
225                 230                 235                 240 


Glu Ala Lys Glu Lys Asn Arg Glu Thr Trp Tyr Leu Ser Trp Ala Leu 
                245                 250                 255     


Asp Thr Asn Gln Glu Glu Arg Asp Lys Gly Lys Thr Val Glu Val Gly 
            260                 265                 270         


Arg Ala Tyr Phe Glu Thr Glu Arg Lys His Phe Thr Ile Leu Asp Ala 
        275                 280                 285             


Pro Gly His Lys Ser Phe Val Pro Asn Met Ile Gly Gly Ala Ser Gln 
    290                 295                 300                 


Ala Asp Leu Ala Val Leu Val Ile Ser Ala Arg Lys Gly Glu Phe Glu 
305                 310                 315                 320 


Thr Gly Phe Glu Lys Gly Gly Gln Thr Arg Glu His Ala Met Leu Ala 
                325                 330                 335     


Lys Thr Ala Gly Val Lys His Leu Ile Val Leu Ile Asn Lys Met Asp 
            340                 345                 350         


Asp Pro Thr Val Asn Trp Ser Ile Glu Arg Tyr Glu Glu Cys Lys Glu 
        355                 360                 365             


Lys Leu Val Pro Phe Leu Lys Lys Val Gly Phe Ser Pro Lys Lys Asp 
    370                 375                 380                 


Ile His Phe Met Pro Cys Ser Gly Leu Thr Gly Ala Asn Ile Lys Glu 
385                 390                 395                 400 


Gln Ser Asp Phe Cys Pro Trp Tyr Thr Gly Leu Pro Phe Ile Pro Tyr 
                405                 410                 415     


Leu Asp Asn Leu Pro Asn Phe Asn Arg Ser Ile Asp Gly Pro Ile Arg 
            420                 425                 430         


Leu Pro Ile Val Asp Lys Tyr Lys Asp Met Gly Thr Val Val Leu Gly 
        435                 440                 445             


Lys Leu Glu Ser Gly Ser Ile Phe Lys Gly Gln Gln Leu Val Met Met 
    450                 455                 460                 


Pro Asn Lys His Asn Val Glu Val Leu Gly Ile Leu Ser Asp Asp Thr 
465                 470                 475                 480 


Glu Thr Asp Phe Val Ala Pro Gly Glu Asn Leu Lys Ile Arg Leu Lys 
                485                 490                 495     


Gly Ile Glu Glu Glu Glu Ile Leu Pro Gly Phe Ile Leu Cys Asp Pro 
            500                 505                 510         


Ser Asn Leu Cys His Ser Gly Arg Thr Phe Asp Val Gln Ile Val Ile 
        515                 520                 525             


Ile Glu His Lys Ser Ile Ile Cys Pro Gly Tyr Asn Ala Val Leu His 
    530                 535                 540                 


Ile His Thr Cys Ile Glu Glu Val Glu Ile Thr Ala Leu Ile Ser Leu 
545                 550                 555                 560 


Val Asp Lys Lys Ser Gly Glu Lys Ser Lys Thr Arg Pro Arg Phe Val 
                565                 570                 575     


Lys Gln Asp Gln Val Cys Ile Ala Arg Leu Arg Thr Ala Gly Thr Ile 
            580                 585                 590         


Cys Leu Glu Thr Phe Lys Asp Phe Pro Gln Met Gly Arg Phe Thr Leu 
        595                 600                 605             


Arg Asp Glu Gly Lys Thr Ile Ala Ile Gly Lys Val Leu Lys Leu Val 
    610                 615                 620                 


Pro Glu Lys Asp 
625             


<210>  4766
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSR__Homo_sapiens__NP_000628

<400>  4766

Met Ala Leu Leu Pro Arg Ala Leu Ser Ala Gly Ala Gly Pro Ser Trp 
1               5                   10                  15      


Arg Arg Ala Ala Arg Ala Phe Arg Gly Phe Leu Leu Leu Leu Pro Glu 
            20                  25                  30          


Pro Ala Ala Leu Thr Arg Ala Leu Ser Arg Ala Met Ala Cys Arg Gln 
        35                  40                  45              


Glu Pro Gln Pro Gln Gly Pro Pro Pro Ala Ala Gly Ala Val Ala Ser 
    50                  55                  60                  


Tyr Asp Tyr Leu Val Ile Gly Gly Gly Ser Gly Gly Leu Ala Ser Ala 
65                  70                  75                  80  


Arg Arg Ala Ala Glu Leu Gly Ala Arg Ala Ala Val Val Glu Ser His 
                85                  90                  95      


Lys Leu Gly Gly Thr Cys Val Asn Val Gly Cys Val Pro Lys Lys Val 
            100                 105                 110         


Met Trp Asn Thr Ala Val His Ser Glu Phe Met His Asp His Ala Asp 
        115                 120                 125             


Tyr Gly Phe Pro Ser Cys Glu Gly Lys Phe Asn Trp Arg Val Ile Lys 
    130                 135                 140                 


Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu Asn Ala Ile Tyr Gln Asn 
145                 150                 155                 160 


Asn Leu Thr Lys Ser His Ile Glu Ile Ile Arg Gly His Ala Ala Phe 
                165                 170                 175     


Thr Ser Asp Pro Lys Pro Thr Ile Glu Val Ser Gly Lys Lys Tyr Thr 
            180                 185                 190         


Ala Pro His Ile Leu Ile Ala Thr Gly Gly Met Pro Ser Thr Pro His 
        195                 200                 205             


Glu Ser Gln Ile Pro Gly Ala Ser Leu Gly Ile Thr Ser Asp Gly Phe 
    210                 215                 220                 


Phe Gln Leu Glu Glu Leu Pro Gly Arg Ser Val Ile Val Gly Ala Gly 
225                 230                 235                 240 


Tyr Ile Ala Val Glu Met Ala Gly Ile Leu Ser Ala Leu Gly Ser Lys 
                245                 250                 255     


Thr Ser Leu Met Ile Arg His Asp Lys Val Leu Arg Ser Phe Asp Ser 
            260                 265                 270         


Met Ile Ser Thr Asn Cys Thr Glu Glu Leu Glu Asn Ala Gly Val Glu 
        275                 280                 285             


Val Leu Lys Phe Ser Gln Val Lys Glu Val Lys Lys Thr Leu Ser Gly 
    290                 295                 300                 


Leu Glu Val Ser Met Val Thr Ala Val Pro Gly Arg Leu Pro Val Met 
305                 310                 315                 320 


Thr Met Ile Pro Asp Val Asp Cys Leu Leu Trp Ala Ile Gly Arg Val 
                325                 330                 335     


Pro Asn Thr Lys Asp Leu Ser Leu Asn Lys Leu Gly Ile Gln Thr Asp 
            340                 345                 350         


Asp Lys Gly His Ile Ile Val Asp Glu Phe Gln Asn Thr Asn Val Lys 
        355                 360                 365             


Gly Ile Tyr Ala Val Gly Asp Val Cys Gly Lys Ala Leu Leu Thr Pro 
    370                 375                 380                 


Val Ala Ile Ala Ala Gly Arg Lys Leu Ala His Arg Leu Phe Glu Tyr 
385                 390                 395                 400 


Lys Glu Asp Ser Lys Leu Asp Tyr Asn Asn Ile Pro Thr Val Val Phe 
                405                 410                 415     


Ser His Pro Pro Ile Gly Thr Val Gly Leu Thr Glu Asp Glu Ala Ile 
            420                 425                 430         


His Lys Tyr Gly Ile Glu Asn Val Lys Thr Tyr Ser Thr Ser Phe Thr 
        435                 440                 445             


Pro Met Tyr His Ala Val Thr Lys Arg Lys Thr Lys Cys Val Met Lys 
    450                 455                 460                 


Met Val Cys Ala Asn Lys Glu Glu Lys Val Val Gly Ile His Met Gln 
465                 470                 475                 480 


Gly Leu Gly Cys Asp Glu Met Leu Gln Gly Phe Ala Val Ala Val Lys 
                485                 490                 495     


Met Gly Ala Thr Lys Ala Asp Phe Asp Asn Thr Val Ala Ile His Pro 
            500                 505                 510         


Thr Ser Ser Glu Glu Leu Val Thr Leu Arg 
        515                 520         


<210>  4767
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSS__Homo_sapiens__XP_011527098

<400>  4767

Met Ala Thr Asn Trp Gly Ser Leu Leu Gln Asp Lys Gln Gln Leu Glu 
1               5                   10                  15      


Glu Leu Ala Arg Gln Ala Val Asp Arg Ala Leu Ala Glu Gly Val Leu 
            20                  25                  30          


Leu Arg Thr Ser Gln Glu Pro Thr Ser Ser Glu Val Val Ser Tyr Ala 
        35                  40                  45              


Pro Phe Thr Leu Phe Pro Ser Leu Val Pro Ser Ala Leu Leu Glu Gln 
    50                  55                  60                  


Ala Tyr Ala Val Gln Met Asp Phe Asn Leu Leu Val Asp Ala Val Ser 
65                  70                  75                  80  


Gln Asn Ala Ala Phe Leu Glu Gln Thr Leu Ser Ser Thr Ile Lys Gln 
                85                  90                  95      


Asp Asp Phe Thr Ala Arg Leu Phe Asp Ile His Lys Gln Val Leu Lys 
            100                 105                 110         


Glu Gly Ile Ala Gln Thr Val Phe Leu Gly Leu Asn Arg Ser Asp Tyr 
        115                 120                 125             


Met Phe Gln Arg Ser Ala Asp Gly Ser Pro Ala Leu Lys Gln Ile Glu 
    130                 135                 140                 


Ile Asn Thr Ile Ser Ala Ser Phe Gly Gly Leu Ala Ser Arg Thr Pro 
145                 150                 155                 160 


Ala Val His Arg His Val Leu Ser Val Leu Ser Lys Thr Lys Glu Ala 
                165                 170                 175     


Gly Lys Ile Leu Ser Asn Asn Pro Ser Lys Gly Leu Ala Leu Gly Ile 
            180                 185                 190         


Ala Lys Ala Trp Glu Leu Tyr Gly Ser Pro Asn Ala Leu Val Leu Leu 
        195                 200                 205             


Ile Ala Gln Glu Lys Glu Arg Asn Ile Phe Asp Gln Arg Ala Ile Glu 
    210                 215                 220                 


Asn Glu Leu Leu Ala Arg Asn Ile His Val Ile Arg Arg Thr Phe Glu 
225                 230                 235                 240 


Asp Ile Ser Glu Lys Gly Ser Leu Asp Gln Asp Arg Arg Leu Phe Val 
                245                 250                 255     


Asp Gly Gln Glu Ile Ala Val Val Tyr Phe Arg Asp Gly Tyr Met Pro 
            260                 265                 270         


Arg Gln Tyr Ser Leu Gln Asn Trp Glu Ala Arg Leu Leu Leu Glu Arg 
        275                 280                 285             


Ser His Ala Ala Lys Cys Pro Asp Ile Ala Thr Gln Leu Ala Gly Thr 
    290                 295                 300                 


Lys Lys Val Gln Gln Glu Leu Ser Arg Pro Gly Met Leu Glu Met Leu 
305                 310                 315                 320 


Leu Pro Gly Gln Pro Glu Ala Val Ala Arg Leu Arg Ala Thr Phe Ala 
                325                 330                 335     


Gly Leu Tyr Ser Leu Asp Val Gly Glu Glu Gly Asp Gln Ala Ile Ala 
            340                 345                 350         


Glu Ala Leu Ala Ala Pro Ser Arg Phe Val Leu Lys Pro Gln Arg Glu 
        355                 360                 365             


Gly Gly Gly Asn Asn Leu Tyr Gly Glu Glu Met Val Gln Ala Leu Lys 
    370                 375                 380                 


Gln Leu Lys Asp Ser Glu Glu Arg Ala Ser Tyr Ile Leu Met Glu Lys 
385                 390                 395                 400 


Ile Glu Pro Glu Pro Phe Glu Asn Cys Leu Leu Arg Pro Gly Ser Pro 
                405                 410                 415     


Ala Arg Val Val Gln Cys Ile Ser Glu Leu Gly Ile Phe Gly Val Tyr 
            420                 425                 430         


Val Arg Gln Glu Lys Thr Leu Val Met Asn Lys His Val Gly His Leu 
        435                 440                 445             


Leu Arg Thr Lys Ala Ile Glu His Ala Asp Gly Gly Val Ala Ala Gly 
    450                 455                 460                 


Val Ala Val Leu Asp Asn Pro Tyr Pro Val 
465                 470                 


<210>  4768
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTA1__Homo_sapiens__NP_665683

<400>  4768

Met Ala Glu Lys Pro Lys Leu His Tyr Phe Asn Ala Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Thr Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
            20                  25                  30          


Lys Phe Ile Lys Ser Ala Glu Asp Leu Asp Lys Leu Arg Asn Asp Gly 
        35                  40                  45              


Tyr Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
65                  70                  75                  80  


Leu Tyr Gly Lys Asp Ile Lys Glu Arg Ala Leu Ile Asp Met Tyr Ile 
                85                  90                  95      


Glu Gly Ile Ala Asp Leu Gly Glu Met Ile Leu Leu Leu Pro Val Cys 
            100                 105                 110         


Pro Pro Glu Glu Lys Asp Ala Lys Leu Ala Leu Ile Lys Glu Lys Ile 
        115                 120                 125             


Lys Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Gly 
    130                 135                 140                 


Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile His Leu 
145                 150                 155                 160 


Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
            180                 185                 190         


Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Met 
        195                 200                 205             


Asp Glu Lys Ser Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
    210                 215                 220         


<210>  4769
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTA2__Homo_sapiens__XP_011512834

<400>  4769

Met Ala Glu Lys Pro Lys Leu His Tyr Ser Asn Ile Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
            20                  25                  30          


Lys Phe Ile Lys Ser Ala Glu Asp Leu Asp Lys Leu Arg Asn Asp Gly 
        35                  40                  45              


Tyr Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
65                  70                  75                  80  


Leu Tyr Gly Lys Asp Ile Lys Glu Lys Ala Leu Ile Asp Met Tyr Ile 
                85                  90                  95      


Glu Gly Ile Ala Asp Leu Gly Glu Met Ile Leu Leu Leu Pro Phe Ser 
            100                 105                 110         


Gln Pro Glu Glu Gln Asp Ala Lys Leu Ala Leu Ile Gln Glu Lys Thr 
        115                 120                 125             


Lys Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Gly 
    130                 135                 140                 


Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile His Leu 
145                 150                 155                 160 


Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
            180                 185                 190         


Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Met 
        195                 200                 205             


Asp Glu Lys Ser Leu Glu Glu Ser Arg Lys Ile Phe Arg Phe 
    210                 215                 220         


<210>  4770
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTA4__Homo_sapiens__XP_005249092

<400>  4770

Met Ala Ala Arg Pro Lys Leu His Tyr Pro Asn Gly Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Val Arg Trp Val Leu Ala Ala Ala Gly Val Glu Phe Asp Glu 
            20                  25                  30          


Glu Phe Leu Glu Thr Lys Glu Gln Leu Tyr Lys Leu Gln Asp Gly Asn 
        35                  40                  45              


His Leu Leu Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ser Ile Leu His Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Leu Phe Gly Lys Asn Leu Lys Glu Arg Thr Leu Ile Asp Met Tyr Val 
                85                  90                  95      


Glu Gly Thr Leu Asp Leu Leu Glu Leu Leu Ile Met His Pro Phe Leu 
            100                 105                 110         


Lys Pro Asp Asp Gln Gln Lys Glu Val Val Asn Met Ala Gln Lys Ala 
        115                 120                 125             


Ile Ile Arg Tyr Phe Pro Val Phe Glu Lys Ile Leu Arg Gly His Gly 
    130                 135                 140                 


Gln Ser Phe Leu Val Gly Asn Gln Leu Ser Leu Ala Asp Val Ile Leu 
145                 150                 155                 160 


Leu Gln Thr Ile Leu Ala Leu Glu Glu Lys Ile Pro Asn Ile Leu Ser 
                165                 170                 175     


Ala Phe Pro Phe Leu Gln Glu Tyr Thr Val Lys Leu Ser Asn Ile Pro 
            180                 185                 190         


Thr Ile Lys Arg Phe Leu Glu Pro Gly Ser Lys Lys Lys Pro Pro Pro 
        195                 200                 205             


Asp Glu Ile Tyr Val Arg Thr Val Tyr Asn Ile Phe Arg Pro 
    210                 215                 220         


<210>  4771
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTA5__Homo_sapiens__NP_714543

<400>  4771

Met Ala Glu Lys Pro Lys Leu His Tyr Ser Asn Ala Arg Gly Ser Met 
1               5                   10                  15      


Glu Ser Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Leu Glu Glu 
            20                  25                  30          


Lys Phe Leu Glu Ser Ala Glu Asp Leu Asp Lys Leu Arg Asn Asp Gly 
        35                  40                  45              


Ser Leu Leu Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
65                  70                  75                  80  


Leu Tyr Gly Lys Asp Met Lys Glu Arg Ala Leu Ile Asp Met Tyr Thr 
                85                  90                  95      


Glu Gly Ile Val Asp Leu Thr Glu Met Ile Leu Leu Leu Leu Ile Cys 
            100                 105                 110         


Gln Pro Glu Glu Arg Asp Ala Lys Thr Ala Leu Val Lys Glu Lys Ile 
        115                 120                 125             


Lys Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Arg 
    130                 135                 140                 


Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Trp Ala Asp Ile His Leu 
145                 150                 155                 160 


Val Glu Leu Phe Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
            180                 185                 190         


Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Gln Arg Lys Pro Pro Met 
        195                 200                 205             


Asp Glu Lys Ser Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
    210                 215                 220         


<210>  4772
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTCD__Homo_sapiens__NP_001026890

<400>  4772

Met Lys Ala Ile Lys Lys Ser Leu Thr Glu Glu Glu Tyr Leu Tyr Leu 
1               5                   10                  15      


Asp Phe Ser His Gln Thr Glu Gly Cys Ile Phe Pro Leu His Thr Ser 
            20                  25                  30          


Val Thr Leu Phe Leu Leu Ser Tyr Cys Asp Cys Lys Ile Phe Lys Ile 
        35                  40                  45              


Cys Leu Val Val Thr Lys Glu Val Ser Arg Asp Ser Ser Leu Leu Arg 
    50                  55                  60                  


Asp Asp Leu Ile Gln Asp Val Glu Ile Gln Ile Ile Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Pro Pro Ile Val Gln Asn Cys Cys Leu Pro Ala Val Val Glu Arg 
                85                  90                  95      


Ser Asp Asn Phe Cys Arg Ala Gly Leu Ala Val Val Leu Arg His Ile 
            100                 105                 110         


Ile Gln Lys Ser Tyr Glu Ala Asp Pro Leu Lys Lys Glu Leu Leu Glu 
        115                 120                 125             


Leu Leu Gly Phe Lys Lys Thr Cys Leu Lys Ala Cys Ala Glu Val Ser 
    130                 135                 140                 


Gln Trp Thr Arg Leu Cys Glu Leu Thr Ile Pro Leu Ala Ile Glu Asn 
145                 150                 155                 160 


Phe Leu Arg Glu Ser Ser Asp Gln Pro Pro Thr Ile Pro Val Glu Ile 
                165                 170                 175     


Leu Gln Leu Glu Lys Lys Leu Ser Glu Pro Val Arg Val His Asn Asp 
            180                 185                 190         


Asp Lys Leu Arg Arg Gln Lys Leu Lys Gln Gln Lys Ala Asp Gly Val 
        195                 200                 205             


Gly Pro Pro Leu Thr Lys Gly Lys Ala Lys Ser Lys Val His Thr Gln 
    210                 215                 220                 


Glu Thr Ser Glu Gly Leu Asp Ser Ser Ser Lys Ser Leu Glu Leu Lys 
225                 230                 235                 240 


Val Ala Phe Ser Lys Leu Thr Val Gln Glu Glu Pro Ala Thr Thr Asn 
                245                 250                 255     


Arg Glu Pro Ser His Ile Arg Lys Ala Lys Ala Ser Asp Leu Pro Pro 
            260                 265                 270         


Leu Glu His Val Phe Ala Glu Gly Leu Tyr Phe Thr Leu Ala Asp Ile 
        275                 280                 285             


Val Leu Leu Pro Cys Ile His His Phe Leu Val Ile Ile Ser Arg Lys 
    290                 295                 300                 


Phe Ser Glu Lys Leu Val Glu Phe Pro Leu Leu Ala Ser Trp Tyr Gln 
305                 310                 315                 320 


Arg Ile Gln Glu Val Pro Gly Val Lys Thr Ala Ala Ser Lys Cys Gly 
                325                 330                 335     


Ile Gln Phe Leu His Leu Pro Lys Leu Leu Thr Thr Ser Thr Glu Gln 
            340                 345                 350         


His Pro Asn Leu Cys Glu Val Pro Gly Val Glu Glu Gln Ser Asp Pro 
        355                 360                 365             


Leu Phe Ile Gly Gly Pro Arg Pro Thr Met Ala Lys Leu Met Glu Lys 
    370                 375                 380                 


Gly Ile Glu Val Met Phe Ser Pro His Pro Cys Pro Thr Trp Thr Leu 
385                 390                 395                 400 


Asp Trp Asn Val Leu Pro Ala Ala Val Ser Pro Lys Glu Gly Lys Met 
                405                 410                 415     


Ser Ser Asp Arg Ala Leu Arg Lys Gln Gln Gln Leu Asn Asn Leu Val 
            420                 425                 430         


Tyr Val Val Thr Asn Gln Ala Lys Pro Gly Asp Arg Ile Val Asp Phe 
        435                 440                 445             


Cys Ser Gly Gly Gly His Val Gly Ile Val Leu Ala His Met Leu Pro 
    450                 455                 460                 


Ser Cys Gln Val Thr Leu Ile Glu Asn Lys Glu Leu Ser Leu Ile Arg 
465                 470                 475                 480 


Ala Lys Lys Arg Ser Asp Glu Leu Gly Leu Ser Asn Ile Trp Phe Ile 
                485                 490                 495     


Gln Ala Asn Met Glu Tyr Phe Thr Gly Met Phe Asn Ile Gly Val Ala 
            500                 505                 510         


Leu His Ala Cys Gly Val Ala Thr Asp Met Val Ile Glu His Cys Ile 
        515                 520                 525             


Lys Thr Arg Ala Ser Phe Val Thr Cys Pro Cys Cys Tyr Gly Phe Ile 
    530                 535                 540                 


Gln Asn Thr Ser Lys Phe Asn Phe Pro Lys Ser Glu Gln Phe Lys Lys 
545                 550                 555                 560 


Thr Leu Ser Tyr Lys Glu His Met Ile Leu Cys Arg Phe Ala Asp Gln 
                565                 570                 575     


Thr Ala Val Gln Leu Pro Pro Gln Arg Arg Leu Ile Gly Lys Gln Cys 
            580                 585                 590         


Met Cys Leu Val Asp Leu Asp Arg Ala Arg Ala Ala Glu Glu Cys Gly 
        595                 600                 605             


Tyr Ser Val Gln Val Ile Ser Met Glu Pro Glu Ser Cys Ser Pro Lys 
    610                 615                 620                 


Asn Asn Met Ile Val Gly Val Pro Ile 
625                 630             


<210>  4773
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTK1__Homo_sapiens__NP_001137151

<400>  4773

Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Val Ser Val Gly Leu Trp Glu Ser Ser Gly Arg Thr Leu Asp Asp Phe 
    130                 135                 140                 


Leu Thr Phe Pro Arg His Val Phe Arg Val Met Ile Leu Pro Pro Pro 
145                 150                 155                 160 


Gly Gly Ser Thr Val Leu Pro Val Thr Pro Leu Ser Pro His Arg Leu 
                165                 170                 175     


Pro Ala Val Phe Ser Ser Ser Gln Asn Glu Asp Ile Thr Glu Pro Gln 
            180                 185                 190         


Ser Ile Leu Ala Ala Ala Glu Lys Ala Gly Met Ser Ala Glu Gln Ala 
        195                 200                 205             


Gln Gly Leu Leu Glu Lys Ile Ala Thr Pro Lys Val Lys Asn Gln Leu 
    210                 215                 220                 


Lys Glu Thr Thr Glu Ala Ala Cys Arg Tyr Gly Ala Phe Gly Leu Pro 
225                 230                 235                 240 


Ile Thr Val Ala His Val Asp Gly Gln Thr His Met Leu Phe Gly Ser 
                245                 250                 255     


Asp Arg Met Glu Leu Leu Ala His Leu Leu Gly Glu Lys Trp Met Gly 
            260                 265                 270         


Pro Ile Pro Pro Ala Val Asn Ala Arg Leu 
        275                 280         


<210>  4774
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTM3__Homo_sapiens__XP_011539598

<400>  4774

Met Asn Glu Val Trp Leu Pro Pro Ala Gly Lys Gly Gly Ala Ser Thr 
1               5                   10                  15      


Ser Gly Pro Leu Leu Ser Cys Ser Thr Pro Ala Arg Val Pro Pro Arg 
            20                  25                  30          


Gly Arg Gln Ala Leu Asn Pro Asn Ala Gly Ile Ser Arg Ala Cys Ala 
        35                  40                  45              


Arg Pro Cys Gly Ala Ala Glu Ala Arg Asp Gly Glu Arg Gly Gly Gly 
    50                  55                  60                  


Gly Val Arg Ala Pro Ala Arg Gly Pro Arg Pro Leu Met Ser Gly Ile 
65                  70                  75                  80  


Lys Pro Leu Pro Leu Thr Val Ser Leu Val Leu Glu Gly Ser Glu Ala 
                85                  90                  95      


Arg His His Val Val Arg Val Val Tyr Gly Ser Arg Val Leu Gly Tyr 
            100                 105                 110         


Ser Trp Ala Pro Asp Tyr Asp Arg Ser Gln Trp Leu Asp Val Lys Phe 
        115                 120                 125             


Lys Leu Asp Leu Asp Phe Pro Asn Leu Pro Tyr Leu Leu Asp Gly Lys 
    130                 135                 140                 


Asn Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Ile Ala Arg Lys 
145                 150                 155                 160 


His Asn Met Cys Gly Glu Thr Glu Glu Glu Lys Ile Arg Val Asp Ile 
                165                 170                 175     


Ile Glu Asn Gln Val Met Asp Phe Arg Thr Gln Leu Ile Arg Leu Cys 
            180                 185                 190         


Tyr Ser Ser Asp His Glu Lys Leu Lys Pro Gln Tyr Leu Glu Glu Leu 
        195                 200                 205             


Pro Gly Gln Leu Lys Gln Phe Ser Met Phe Leu Gly Lys Phe Ser Trp 
    210                 215                 220                 


Phe Ala Gly Glu Lys Leu Thr Phe Val Asp Phe Leu Thr Tyr Asp Ile 
225                 230                 235                 240 


Leu Asp Gln Asn Arg Ile Phe Asp Pro Lys Cys Leu Asp Glu Phe Pro 
                245                 250                 255     


Asn Leu Lys Ala Phe Met Cys Arg Phe Glu Ala Leu Glu Lys Ile Ala 
            260                 265                 270         


Ala Tyr Leu Gln Ser Asp Gln Phe Cys Lys Met Pro Ile Asn Asn Lys 
        275                 280                 285             


Met Ala Gln Trp Gly Asn Lys Pro Val Cys 
    290                 295             


<210>  4775
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTO1__Homo_sapiens__NP_001177931

<400>  4775

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
        35                  40                  45              


His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
    50                  55                  60                  


Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                85                  90                  95      


Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
            100                 105                 110         


Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Leu Thr Asn Lys Lys 
        115                 120                 125             


Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu Ile 
    130                 135                 140                 


Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys Val 
145                 150                 155                 160 


Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu Asp 
                165                 170                 175     


Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly Phe 
            180                 185                 190         


Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly Leu 
        195                 200                 205             


<210>  4776
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTO2__Homo_sapiens__NP_001177942

<400>  4776

Met Ser Gly Asp Ala Thr Arg Thr Leu Gly Lys Gly Ser Gln Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Leu Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Tyr Ser His Arg Thr Arg Leu Val Leu Lys Ala Lys Asp Ile Arg 
        35                  40                  45              


His Glu Val Val Asn Ile Asn Leu Arg Asn Lys Pro Glu Trp Tyr Tyr 
    50                  55                  60                  


Thr Lys His Pro Phe Gly His Ile Pro Val Leu Glu Thr Ser Gln Cys 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Val Ile Ala Cys Glu Tyr Leu Asp Asp Ala 
                85                  90                  95      


Tyr Pro Gly Arg Lys Leu Phe Pro Tyr Asp Pro Tyr Glu Arg Ala Arg 
            100                 105                 110         


Gln Lys Met Leu Leu Glu Leu Phe Cys Lys Ile Leu Glu Tyr Gln Asn 
        115                 120                 125             


Thr Thr Phe Phe Gly Gly Thr Cys Ile Ser Met Ile Asp Tyr Leu Leu 
    130                 135                 140                 


Trp Pro Trp Phe Glu Arg Leu Asp Val Tyr Gly Ile Leu Asp Cys Val 
145                 150                 155                 160 


Ser His Thr Pro Ala Leu Arg Leu Trp Ile Ser Ala Met Lys Trp Asp 
                165                 170                 175     


Pro Thr Val Cys Ala Leu Leu Met Asp Lys Ser Ile Phe Gln Gly Phe 
            180                 185                 190         


Leu Asn Leu Tyr Phe Gln Asn Asn Pro Asn Ala Phe Asp Phe Gly Leu 
        195                 200                 205             


Cys 
    


<210>  4777
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTP1__Homo_sapiens__NP_000843

<400>  4777

Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala 
1               5                   10                  15      


Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu 
            20                  25                  30          


Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys 
        35                  40                  45              


Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr 
    50                  55                  60                  


Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr 
65                  70                  75                  80  


Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly 
                85                  90                  95      


Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr 
            100                 105                 110         


Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys 
        115                 120                 125             


Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile 
    130                 135                 140                 


Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu 
145                 150                 155                 160 


Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu 
                165                 170                 175     


Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala 
            180                 185                 190         


Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
        195                 200                 205             


Lys Gln 
    210 


<210>  4778
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTT1__Homo_sapiens__NP_000844

<400>  4778

Met Gly Leu Glu Leu Tyr Leu Asp Leu Leu Ser Gln Pro Cys Arg Ala 
1               5                   10                  15      


Val Tyr Ile Phe Ala Lys Lys Asn Asp Ile Pro Phe Glu Leu Arg Ile 
            20                  25                  30          


Val Asp Leu Ile Lys Gly Gln His Leu Ser Asp Ala Phe Ala Gln Val 
        35                  40                  45              


Asn Pro Leu Lys Lys Val Pro Ala Leu Lys Asp Gly Asp Phe Thr Leu 
    50                  55                  60                  


Thr Glu Ser Val Ala Ile Leu Leu Tyr Leu Thr Arg Lys Tyr Lys Val 
65                  70                  75                  80  


Pro Asp Tyr Trp Tyr Pro Gln Asp Leu Gln Ala Arg Ala Arg Val Asp 
                85                  90                  95      


Glu Tyr Leu Ala Trp Gln His Thr Thr Leu Arg Arg Ser Cys Leu Arg 
            100                 105                 110         


Ala Leu Trp His Lys Val Met Phe Pro Val Phe Leu Gly Glu Pro Val 
        115                 120                 125             


Ser Pro Gln Thr Leu Ala Ala Thr Leu Ala Glu Leu Asp Val Thr Leu 
    130                 135                 140                 


Gln Leu Leu Glu Asp Lys Phe Leu Gln Asn Lys Ala Phe Leu Thr Gly 
145                 150                 155                 160 


Pro His Ile Ser Leu Ala Asp Leu Val Ala Ile Thr Glu Leu Met His 
                165                 170                 175     


Pro Val Gly Ala Gly Cys Gln Val Phe Glu Gly Arg Pro Lys Leu Ala 
            180                 185                 190         


Thr Trp Arg Gln Arg Val Glu Ala Ala Val Gly Glu Asp Leu Phe Gln 
        195                 200                 205             


Glu Ala His Glu Val Ile Leu Lys Ala Lys Asp Phe Pro Pro Ala Asp 
    210                 215                 220                 


Pro Thr Ile Lys Gln Lys Leu Met Pro Trp Val Leu Ala Met Ile Arg 
225                 230                 235                 240 


<210>  4779
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTT2B__Homo_sapiens__NP_001074312

<400>  4779

Met Gly Leu Glu Leu Phe Leu Asp Leu Val Ser Gln Pro Ser Arg Ala 
1               5                   10                  15      


Val Tyr Ile Phe Ala Lys Lys Asn Gly Ile Pro Leu Glu Leu Arg Thr 
            20                  25                  30          


Val Asp Leu Val Lys Gly Gln His Lys Ser Lys Glu Phe Leu Gln Ile 
        35                  40                  45              


Asn Ser Leu Gly Lys Leu Pro Thr Leu Lys Asp Gly Asp Phe Ile Leu 
    50                  55                  60                  


Thr Glu Ser Ser Ala Ile Leu Ile Tyr Leu Ser Cys Lys Tyr Gln Thr 
65                  70                  75                  80  


Pro Asp His Trp Tyr Pro Ser Asp Leu Gln Ala Arg Ala Arg Val His 
                85                  90                  95      


Glu Tyr Leu Gly Trp His Ala Asp Cys Ile Arg Gly Thr Phe Gly Ile 
            100                 105                 110         


Pro Leu Trp Val Gln Val Leu Gly Pro Leu Ile Gly Val Gln Val Pro 
        115                 120                 125             


Glu Glu Lys Val Glu Arg Asn Arg Thr Ala Met Asp Gln Ala Leu Gln 
    130                 135                 140                 


Trp Leu Glu Asp Lys Phe Leu Gly Asp Arg Pro Phe Leu Ala Gly Gln 
145                 150                 155                 160 


Gln Val Thr Leu Ala Asp Leu Met Ala Leu Glu Glu Leu Met Gln Pro 
                165                 170                 175     


Val Ala Leu Gly Tyr Glu Leu Phe Glu Gly Arg Pro Arg Leu Ala Ala 
            180                 185                 190         


Trp Arg Gly Arg Val Glu Ala Phe Leu Gly Ala Glu Leu Cys Gln Glu 
        195                 200                 205             


Ala His Ser Ile Ile Leu Ser Ile Leu Glu Gln Ala Ala Lys Lys Thr 
    210                 215                 220                 


Leu Pro Thr Pro Ser Pro Glu Ala Tyr Gln Ala Met Leu Leu Arg Ile 
225                 230                 235                 240 


Ala Arg Ile Pro 
                


<210>  4780
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTT2__Homo_sapiens__NP_000845

<400>  4780

Met Gly Leu Glu Leu Phe Leu Asp Leu Val Ser Gln Pro Ser Arg Ala 
1               5                   10                  15      


Val Tyr Ile Phe Ala Lys Lys Asn Gly Ile Pro Leu Glu Leu Arg Thr 
            20                  25                  30          


Val Asp Leu Val Lys Gly Gln His Lys Ser Lys Glu Phe Leu Gln Ile 
        35                  40                  45              


Asn Ser Leu Gly Lys Leu Pro Thr Leu Lys Asp Gly Asp Phe Ile Leu 
    50                  55                  60                  


Thr Glu Ser Ser Ala Ile Leu Ile Tyr Leu Ser Cys Lys Tyr Gln Thr 
65                  70                  75                  80  


Pro Asp His Trp Tyr Pro Ser Asp Leu Gln Ala Arg Ala Arg Val His 
                85                  90                  95      


Glu Tyr Leu Gly Trp His Ala Asp Cys Ile Arg Gly Thr Phe Gly Ile 
            100                 105                 110         


Pro Leu Trp Val Gln Val Leu Gly Pro Leu Ile Gly Val Gln Val Pro 
        115                 120                 125             


Lys Glu Lys Val Glu Arg Asn Arg Thr Ala Met Asp Gln Ala Leu Gln 
    130                 135                 140                 


Trp Leu Glu Asp Lys Phe Leu Gly Asp Arg Pro Phe Leu Ala Gly Gln 
145                 150                 155                 160 


Gln Val Thr Leu Ala Asp Leu Met Ala Leu Glu Glu Leu Met Gln Pro 
                165                 170                 175     


Val Ala Leu Gly Tyr Glu Leu Phe Glu Gly Arg Pro Arg Leu Ala Ala 
            180                 185                 190         


Trp Arg Gly Arg Val Glu Ala Phe Leu Gly Ala Glu Leu Cys Gln Glu 
        195                 200                 205             


Ala His Ser Ile Ile Leu Ser Ile Leu Glu Gln Ala Ala Lys Lys Thr 
    210                 215                 220                 


Leu Pro Thr Pro Ser Pro Glu Ala Tyr Gln Ala Met Leu Leu Arg Ile 
225                 230                 235                 240 


Ala Arg Ile Pro 
                


<210>  4781
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSTZ1__Homo_sapiens__NP_665877

<400>  4781

Met Gln Ala Gly Lys Pro Ile Leu Tyr Ser Tyr Phe Arg Ser Ser Cys 
1               5                   10                  15      


Ser Trp Arg Val Arg Ile Ala Leu Ala Leu Lys Gly Ile Asp Tyr Glu 
            20                  25                  30          


Thr Val Pro Ile Asn Leu Ile Lys Asp Gly Gly Gln Gln Phe Ser Lys 
        35                  40                  45              


Asp Phe Gln Ala Leu Asn Pro Met Lys Gln Val Pro Thr Leu Lys Ile 
    50                  55                  60                  


Asp Gly Ile Thr Ile His Gln Ser Leu Ala Ile Ile Glu Tyr Leu Glu 
65                  70                  75                  80  


Glu Met Arg Pro Thr Pro Arg Leu Leu Pro Gln Asp Pro Lys Lys Arg 
                85                  90                  95      


Ala Ser Val Arg Met Ile Ser Asp Leu Ile Ala Gly Gly Ile Gln Pro 
            100                 105                 110         


Leu Gln Asn Leu Ser Val Leu Lys Gln Val Gly Glu Glu Met Gln Leu 
        115                 120                 125             


Thr Trp Ala Gln Asn Ala Ile Thr Cys Gly Phe Asn Ala Leu Glu Gln 
    130                 135                 140                 


Ile Leu Gln Ser Thr Ala Gly Ile Tyr Cys Val Gly Asp Glu Val Thr 
145                 150                 155                 160 


Met Ala Asp Leu Cys Leu Val Pro Gln Val Ala Asn Ala Glu Arg Phe 
                165                 170                 175     


Lys Val Asp Leu Thr Pro Tyr Pro Thr Ile Ser Ser Ile Asn Lys Arg 
            180                 185                 190         


Leu Leu Val Leu Glu Ala Phe Gln Val Ser His Pro Cys Arg Gln Pro 
        195                 200                 205             


Asp Thr Pro Thr Glu Leu Arg Ala 
    210                 215     


<210>  4782
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSX1__Homo_sapiens__NP_663632

<400>  4782

Met Pro Arg Ser Phe Leu Val Asp Ser Leu Val Leu Arg Glu Ala Gly 
1               5                   10                  15      


Glu Lys Lys Ala Pro Glu Gly Ser Pro Pro Pro Leu Phe Pro Tyr Ala 
            20                  25                  30          


Val Pro Pro Pro His Ala Leu His Gly Leu Ser Pro Gly Ala Cys His 
        35                  40                  45              


Ala Arg Lys Ala Gly Leu Leu Cys Val Cys Pro Leu Cys Val Thr Ala 
    50                  55                  60                  


Ser Gln Leu His Gly Pro Pro Gly Pro Pro Ala Leu Pro Leu Leu Lys 
65                  70                  75                  80  


Ala Ser Phe Pro Pro Phe Gly Ser Gln Tyr Cys His Ala Pro Leu Gly 
                85                  90                  95      


Arg Gln His Ser Ala Val Ser Pro Gly Val Ala His Gly Pro Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Leu Tyr Gln Thr Ser Tyr Pro Leu Pro Asp 
        115                 120                 125             


Pro Arg Gln Phe His Cys Ile Ser Val Asp Ser Ser Ser Asn Gln Leu 
    130                 135                 140                 


Pro Ser Ser Lys Arg Met Arg Thr Ala Phe Thr Ser Thr Gln Leu Leu 
145                 150                 155                 160 


Glu Leu Glu Arg Glu Phe Ala Ser Asn Met Tyr Leu Ser Arg Leu Arg 
                165                 170                 175     


Arg Ile Glu Ile Ala Thr Tyr Leu Asn Leu Ser Glu Lys Gln Val Lys 
            180                 185                 190         


Ile Trp Phe Gln Asn Arg Arg Val Lys His Lys Lys Glu Gly Lys Gly 
        195                 200                 205             


Ser Asn His Arg Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Ser 
    210                 215                 220                 


Ala Pro Gln Gly Cys Lys Cys Ala Ser Leu Ser Ser Ala Lys Cys Ser 
225                 230                 235                 240 


Glu Asp Asp Asp Glu Leu Pro Met Ser Pro Ser Ser Ser Gly Lys Asp 
                245                 250                 255     


Asp Arg Asp Leu Thr Val Thr Pro 
            260                 


<210>  4783
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSX2__Homo_sapiens__NP_573574

<400>  4783

Met Ser Arg Ser Phe Tyr Val Asp Ser Leu Ile Ile Lys Asp Thr Ser 
1               5                   10                  15      


Arg Pro Ala Pro Ser Leu Pro Glu Pro His Pro Gly Pro Asp Phe Phe 
            20                  25                  30          


Ile Pro Leu Gly Met Pro Pro Pro Leu Val Met Ser Val Ser Gly Pro 
        35                  40                  45              


Gly Cys Pro Ser Arg Lys Ser Gly Ala Phe Cys Val Cys Pro Leu Cys 
    50                  55                  60                  


Val Thr Ser His Leu His Ser Ser Arg Gly Ser Val Gly Ala Gly Ser 
65                  70                  75                  80  


Gly Gly Ala Gly Ala Gly Val Thr Gly Ala Gly Gly Ser Gly Val Ala 
                85                  90                  95      


Gly Ala Ala Gly Ala Leu Pro Leu Leu Lys Ser Gln Phe Ser Ser Ala 
            100                 105                 110         


Pro Gly Asp Ala Gln Phe Cys Pro Arg Val Asn His Ala His His His 
        115                 120                 125             


His His Pro Pro Gln His His His His His His Gln Pro Gln Gln Pro 
    130                 135                 140                 


Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Leu Gly His Pro Gln His His Ala Pro Val Cys Thr Ala Thr 
                165                 170                 175     


Thr Tyr Asn Val Ala Asp Pro Arg Arg Phe His Cys Leu Thr Met Gly 
            180                 185                 190         


Gly Ser Asp Ala Ser Gln Val Pro Asn Gly Lys Arg Met Arg Thr Ala 
        195                 200                 205             


Phe Thr Ser Thr Gln Leu Leu Glu Leu Glu Arg Glu Phe Ser Ser Asn 
    210                 215                 220                 


Met Tyr Leu Ser Arg Leu Arg Arg Ile Glu Ile Ala Thr Tyr Leu Asn 
225                 230                 235                 240 


Leu Ser Glu Lys Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Val Lys 
                245                 250                 255     


His Lys Lys Glu Gly Lys Gly Thr Gln Arg Asn Ser His Ala Gly Cys 
            260                 265                 270         


Lys Cys Val Gly Ser Gln Val His Tyr Ala Arg Ser Glu Asp Glu Asp 
        275                 280                 285             


Ser Leu Ser Pro Ala Ser Ala Asn Asp Asp Lys Glu Ile Ser Pro Leu 
    290                 295                 300                 


<210>  4784
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTDC1__Homo_sapiens__NP_001006637

<400>  4784

Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys Gln 
1               5                   10                  15      


Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr Thr 
            20                  25                  30          


Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu Tyr 
        35                  40                  45              


Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe Ala 
    50                  55                  60                  


Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp Leu 
65                  70                  75                  80  


Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile Tyr 
                85                  90                  95      


Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn Gln 
            100                 105                 110         


Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val Phe 
        115                 120                 125             


Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu Ile 
    130                 135                 140                 


Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys Cys 
145                 150                 155                 160 


Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe Met 
                165                 170                 175     


Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys Gly 
            180                 185                 190         


Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu Gln 
        195                 200                 205             


Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Cys Asp Thr 
    210                 215                 220                 


His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser Leu 
225                 230                 235                 240 


Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser Ser 
                245                 250                 255     


Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys Asp 
            260                 265                 270         


Ile Leu Gly Gly Val Asp Asn Gln Gln Arg Leu Leu His Ile Val Trp 
        275                 280                 285             


Pro His Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys Val 
    290                 295                 300                 


Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val Leu 
305                 310                 315                 320 


Gly Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys Lys 
                325                 330                 335     


Ala Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys Asp 
            340                 345                 350         


Asp Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr Ala 
        355                 360                 365             


Lys His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys Gly 
    370                 375                 380                 


Cys Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe Pro 
385                 390                 395                 400 


Ala Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu Gln 
                405                 410                 415     


Asn Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys Gly 
            420                 425                 430         


Glu Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg Ser 
        435                 440                 445             


Leu Leu Thr Thr Glu Pro Arg Glu Asp Leu 
    450                 455             


<210>  4785
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2A1__Homo_sapiens__NP_056943

<400>  4785

Met Ala Asn Ser Ala Asn Thr Asn Thr Val Pro Lys Leu Tyr Arg Ser 
1               5                   10                  15      


Val Ile Glu Asp Val Ile Asn Asp Val Arg Asp Ile Phe Leu Asp Asp 
            20                  25                  30          


Gly Val Asp Glu Gln Val Leu Met Glu Leu Lys Thr Leu Trp Glu Asn 
        35                  40                  45              


Lys Leu Met Gln Ser Arg Ala Val Asp Gly Phe His Ser Glu Glu Gln 
    50                  55                  60                  


Gln Leu Leu Leu Gln Val Gln Gln Gln His Gln Pro Gln Gln Gln Gln 
65                  70                  75                  80  


His His His His His His His Gln Gln Ala Gln Pro Gln Gln Thr Val 
                85                  90                  95      


Pro Gln Gln Ala Gln Thr Gln Gln Val Leu Ile Pro Ala Ser Gln Gln 
            100                 105                 110         


Ala Thr Ala Pro Gln Val Ile Val Pro Asp Ser Lys Leu Ile Gln His 
        115                 120                 125             


Met Asn Ala Ser Asn Met Ser Ala Ala Ala Thr Ala Ala Thr Leu Ala 
    130                 135                 140                 


Leu Pro Ala Gly Val Thr Pro Val Gln Gln Ile Leu Thr Asn Ser Gly 
145                 150                 155                 160 


Gln Leu Leu Gln Val Val Arg Ala Ala Asn Gly Ala Gln Tyr Ile Phe 
                165                 170                 175     


Gln Pro Gln Gln Ser Val Val Leu Gln Gln Gln Val Ile Pro Gln Met 
            180                 185                 190         


Gln Pro Gly Gly Val Gln Ala Pro Val Ile Gln Gln Val Leu Ala Pro 
        195                 200                 205             


Leu Pro Gly Gly Ile Ser Pro Gln Thr Gly Val Ile Ile Gln Pro Gln 
    210                 215                 220                 


Gln Ile Leu Phe Thr Gly Asn Lys Thr Gln Val Ile Pro Thr Thr Val 
225                 230                 235                 240 


Ala Ala Pro Thr Pro Ala Gln Ala Gln Ile Thr Ala Thr Gly Gln Gln 
                245                 250                 255     


Gln Pro Gln Ala Gln Pro Ala Gln Thr Gln Ala Pro Leu Val Leu Gln 
            260                 265                 270         


Val Asp Gly Thr Gly Asp Thr Ser Ser Glu Glu Asp Glu Asp Glu Glu 
        275                 280                 285             


Glu Asp Tyr Asp Asp Asp Glu Glu Glu Asp Lys Glu Lys Asp Gly Ala 
    290                 295                 300                 


Glu Asp Gly Gln Val Glu Glu Glu Pro Leu Asn Ser Glu Asp Asp Val 
305                 310                 315                 320 


Ser Asp Glu Glu Gly Gln Glu Leu Phe Asp Thr Glu Asn Val Val Val 
                325                 330                 335     


Cys Gln Tyr Asp Lys Ile His Arg Ser Lys Asn Lys Trp Lys Phe His 
            340                 345                 350         


Leu Lys Asp Gly Ile Met Asn Leu Asn Gly Arg Asp Tyr Ile Phe Ser 
        355                 360                 365             


Lys Ala Ile Gly Asp Ala Glu Trp 
    370                 375     


<210>  4786
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2A1L__Homo_sapiens__NP_001180416

<400>  4786

Met Ala Cys Leu Asn Pro Val Leu Trp Glu Thr Lys Val Leu Gln Ser 
1               5                   10                  15      


Lys Ala Thr Glu Asp Phe Phe Arg Asn Ser Ile Gln Ser Pro Leu Phe 
            20                  25                  30          


Thr Leu Gln Leu Pro His Ser Leu His Gln Thr Leu Gln Ser Ser Thr 
        35                  40                  45              


Ala Ser Leu Val Ile Pro Ala Gly Arg Thr Leu Pro Ser Phe Thr Thr 
    50                  55                  60                  


Ala Glu Leu Gly Thr Ser Asn Ser Ser Ala Asn Phe Thr Phe Pro Gly 
65                  70                  75                  80  


Tyr Pro Ile His Val Pro Ala Gly Val Thr Leu Gln Thr Val Ser Gly 
                85                  90                  95      


His Leu Tyr Lys Val Asn Val Pro Ile Met Val Thr Glu Thr Ser Gly 
            100                 105                 110         


Arg Ala Gly Ile Leu Gln His Pro Ile Gln Gln Val Phe Gln Gln Leu 
        115                 120                 125             


Gly Gln Pro Ser Val Ile Gln Thr Ser Val Pro Gln Leu Asn Pro Trp 
    130                 135                 140                 


Ser Leu Gln Ala Thr Thr Glu Lys Ser Gln Arg Ile Glu Thr Val Leu 
145                 150                 155                 160 


Gln Gln Pro Ala Ile Leu Pro Ser Gly Pro Val Asp Arg Lys His Leu 
                165                 170                 175     


Glu Asn Ala Thr Ser Asp Ile Leu Val Ser Pro Gly Asn Glu His Lys 
            180                 185                 190         


Ile Val Pro Glu Ala Leu Leu Cys His Gln Glu Ser Ser His Tyr Ile 
        195                 200                 205             


Ser Leu Pro Gly Val Val Phe Ser Pro Gln Val Ser Gln Thr Asn Ser 
    210                 215                 220                 


Asn Val Glu Ser Val Leu Ser Gly Ser Ala Ser Met Ala Gln Asn Leu 
225                 230                 235                 240 


His Asp Glu Ser Leu Ser Thr Ser Pro His Gly Ala Leu His Gln His 
                245                 250                 255     


Val Thr Asp Ile Gln Leu His Ile Leu Lys Asn Arg Met Tyr Gly Cys 
            260                 265                 270         


Asp Ser Val Lys Gln Pro Arg Asn Ile Glu Glu Pro Ser Asn Ile Pro 
        275                 280                 285             


Val Ser Glu Lys Asp Ser Asn Ser Gln Val Asp Leu Ser Ile Arg Val 
    290                 295                 300                 


Thr Asp Asp Asp Ile Gly Glu Ile Ile Gln Val Asp Gly Ser Gly Asp 
305                 310                 315                 320 


Thr Ser Ser Asn Glu Glu Ile Gly Ser Thr Arg Asp Ala Asp Glu Asn 
                325                 330                 335     


Glu Phe Leu Gly Asn Ile Asp Gly Gly Asp Leu Lys Val Pro Glu Glu 
            340                 345                 350         


Glu Ala Asp Ser Ile Ser Asn Glu Asp Ser Ala Thr Asn Ser Ser Asp 
        355                 360                 365             


Asn Glu Asp Pro Gln Val Asn Ile Val Glu Glu Asp Pro Leu Asn Ser 
    370                 375                 380                 


Gly Asp Asp Val Ser Glu Gln Asp Val Pro Asp Leu Phe Asp Thr Asp 
385                 390                 395                 400 


Asn Val Ile Val Cys Gln Tyr Asp Lys Ile His Arg Ser Lys Asn Lys 
                405                 410                 415     


Trp Lys Phe Tyr Leu Lys Asp Gly Val Met Cys Phe Gly Gly Arg Asp 
            420                 425                 430         


Tyr Val Phe Ala Lys Ala Ile Gly Asp Ala Glu Trp 
        435                 440                 


<210>  4787
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2A2__Homo_sapiens__NP_004483

<400>  4787

Met Ala Tyr Gln Leu Tyr Arg Asn Thr Thr Leu Gly Asn Ser Leu Gln 
1               5                   10                  15      


Glu Ser Leu Asp Glu Leu Ile Gln Ser Gln Gln Ile Thr Pro Gln Leu 
            20                  25                  30          


Ala Leu Gln Val Leu Leu Gln Phe Asp Lys Ala Ile Asn Ala Ala Leu 
        35                  40                  45              


Ala Gln Arg Val Arg Asn Arg Val Asn Phe Arg Gly Ser Leu Asn Thr 
    50                  55                  60                  


Tyr Arg Phe Cys Asp Asn Val Trp Thr Phe Val Leu Asn Asp Val Glu 
65                  70                  75                  80  


Phe Arg Glu Val Thr Glu Leu Ile Lys Val Asp Lys Val Lys Ile Val 
                85                  90                  95      


Ala Cys Asp Gly Lys Asn Thr Gly Ser Asn Thr Thr Glu 
            100                 105                 


<210>  4788
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2E1__Homo_sapiens__NP_005504

<400>  4788

Met Ala Asp Pro Asp Val Leu Thr Glu Val Pro Ala Ala Leu Lys Arg 
1               5                   10                  15      


Leu Ala Lys Tyr Val Ile Arg Gly Phe Tyr Gly Ile Glu His Ala Leu 
            20                  25                  30          


Ala Leu Asp Ile Leu Ile Arg Asn Ser Cys Val Lys Glu Glu Asp Met 
        35                  40                  45              


Leu Glu Leu Leu Lys Phe Asp Arg Lys Gln Leu Arg Ser Val Leu Asn 
    50                  55                  60                  


Asn Leu Lys Gly Asp Lys Phe Ile Lys Cys Arg Met Arg Val Glu Thr 
65                  70                  75                  80  


Ala Ala Asp Gly Lys Thr Thr Arg His Asn Tyr Tyr Phe Ile Asn Tyr 
                85                  90                  95      


Arg Thr Leu Val Asn Val Val Lys Tyr Lys Leu Asp His Met Arg Arg 
            100                 105                 110         


Arg Ile Glu Thr Asp Glu Arg Asp Ser Thr Asn Arg Ala Ser Phe Lys 
        115                 120                 125             


Cys Pro Val Cys Ser Ser Thr Phe Thr Asp Leu Glu Ala Asn Gln Leu 
    130                 135                 140                 


Phe Asp Pro Met Thr Gly Thr Phe Arg Cys Thr Phe Cys His Thr Glu 
145                 150                 155                 160 


Val Glu Glu Asp Glu Ser Ala Met Pro Lys Lys Asp Ala Arg Thr Leu 
                165                 170                 175     


Leu Ala Arg Phe Asn Glu Gln Ile Glu Pro Ile Tyr Ala Leu Leu Arg 
            180                 185                 190         


Glu Thr Glu Asp Val Asn Leu Ala Tyr Glu Ile Leu Glu Pro Glu Pro 
        195                 200                 205             


Thr Glu Ile Pro Ala Leu Lys Gln Ser Lys Asp His Ala Ala Thr Thr 
    210                 215                 220                 


Ala Gly Ala Ala Ser Leu Ala Gly Gly His His Arg Glu Ala Trp Ala 
225                 230                 235                 240 


Thr Lys Gly Pro Ser Tyr Glu Asp Leu Tyr Thr Gln Asn Val Val Ile 
                245                 250                 255     


Asn Met Asp Asp Gln Glu Asp Leu His Arg Ala Ser Leu Glu Gly Lys 
            260                 265                 270         


Ser Ala Lys Glu Arg Pro Ile Trp Leu Arg Glu Ser Thr Val Gln Gly 
        275                 280                 285             


Ala Tyr Gly Ser Glu Asp Met Lys Glu Gly Gly Ile Asp Met Asp Ala 
    290                 295                 300                 


Phe Gln Glu Arg Glu Glu Gly His Ala Gly Pro Asp Asp Asn Glu Glu 
305                 310                 315                 320 


Val Met Arg Ala Leu Leu Ile His Glu Lys Lys Thr Ser Ser Ala Met 
                325                 330                 335     


Ala Gly Ser Val Gly Ala Ala Ala Pro Val Thr Ala Ala Asn Gly Ser 
            340                 345                 350         


Asp Ser Glu Ser Glu Thr Ser Glu Ser Asp Asp Asp Ser Pro Pro Arg 
        355                 360                 365             


Pro Ala Ala Val Ala Val His Lys Arg Glu Glu Asp Glu Glu Glu Asp 
    370                 375                 380                 


Asp Glu Phe Glu Glu Val Ala Asp Asp Pro Ile Val Met Val Ala Gly 
385                 390                 395                 400 


Arg Pro Phe Ser Tyr Ser Glu Val Ser Gln Arg Pro Glu Leu Val Ala 
                405                 410                 415     


Gln Met Thr Pro Glu Glu Lys Glu Ala Tyr Ile Ala Met Gly Gln Arg 
            420                 425                 430         


Met Phe Glu Asp Leu Phe Glu 
        435                 


<210>  4789
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2E2__Homo_sapiens__NP_002086

<400>  4789

Met Asp Pro Ser Leu Leu Arg Glu Arg Glu Leu Phe Lys Lys Arg Ala 
1               5                   10                  15      


Leu Ser Thr Pro Val Val Glu Lys Arg Ser Ala Ser Ser Glu Ser Ser 
            20                  25                  30          


Ser Ser Ser Ser Lys Lys Lys Lys Thr Lys Val Glu His Gly Gly Ser 
        35                  40                  45              


Ser Gly Ser Lys Gln Asn Ser Asp His Ser Asn Gly Ser Phe Asn Leu 
    50                  55                  60                  


Lys Ala Leu Ser Gly Ser Ser Gly Tyr Lys Phe Gly Val Leu Ala Lys 
65                  70                  75                  80  


Ile Val Asn Tyr Met Lys Thr Arg His Gln Arg Gly Asp Thr His Pro 
                85                  90                  95      


Leu Thr Leu Asp Glu Ile Leu Asp Glu Thr Gln His Leu Asp Ile Gly 
            100                 105                 110         


Leu Lys Gln Lys Gln Trp Leu Met Thr Glu Ala Leu Val Asn Asn Pro 
        115                 120                 125             


Lys Ile Glu Val Ile Asp Gly Lys Tyr Ala Phe Lys Pro Lys Tyr Asn 
    130                 135                 140                 


Val Arg Asp Lys Lys Ala Leu Leu Arg Leu Leu Asp Gln His Asp Gln 
145                 150                 155                 160 


Arg Gly Leu Gly Gly Ile Leu Leu Glu Asp Ile Glu Glu Ala Leu Pro 
                165                 170                 175     


Asn Ser Gln Lys Ala Val Lys Ala Leu Gly Asp Gln Ile Leu Phe Val 
            180                 185                 190         


Asn Arg Pro Asp Lys Lys Lys Ile Leu Phe Phe Asn Asp Lys Ser Cys 
        195                 200                 205             


Gln Phe Ser Val Asp Glu Glu Phe Gln Lys Leu Trp Arg Ser Val Thr 
    210                 215                 220                 


Val Asp Ser Met Asp Glu Glu Lys Ile Glu Glu Tyr Leu Lys Arg Gln 
225                 230                 235                 240 


Gly Ile Ser Ser Met Gln Glu Ser Gly Pro Lys Lys Val Ala Pro Ile 
                245                 250                 255     


Gln Arg Arg Lys Lys Pro Ala Ser Gln Lys Lys Arg Arg Phe Lys Thr 
            260                 265                 270         


His Asn Glu His Leu Ala Gly Val Leu Lys Asp Tyr Ser Asp Ile Thr 
        275                 280                 285             


Ser Ser Lys 
    290     


<210>  4790
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2F1__Homo_sapiens__NP_002087

<400>  4790

Met Ala Ala Leu Gly Pro Ser Ser Gln Asn Val Thr Glu Tyr Val Val 
1               5                   10                  15      


Arg Val Pro Lys Asn Thr Thr Lys Lys Tyr Asn Ile Met Ala Phe Asn 
            20                  25                  30          


Ala Ala Asp Lys Val Asn Phe Ala Thr Trp Asn Gln Ala Arg Leu Glu 
        35                  40                  45              


Arg Asp Leu Ser Asn Lys Lys Ile Tyr Gln Glu Glu Glu Met Pro Glu 
    50                  55                  60                  


Ser Gly Ala Gly Ser Glu Phe Asn Arg Lys Leu Arg Glu Glu Ala Arg 
65                  70                  75                  80  


Arg Lys Lys Tyr Gly Ile Val Leu Lys Glu Phe Arg Pro Glu Asp Gln 
                85                  90                  95      


Pro Trp Leu Leu Arg Val Asn Gly Lys Ser Gly Arg Lys Phe Lys Gly 
            100                 105                 110         


Ile Lys Lys Gly Gly Val Thr Glu Asn Thr Ser Tyr Tyr Ile Phe Thr 
        115                 120                 125             


Gln Cys Pro Asp Gly Ala Phe Glu Ala Phe Pro Val His Asn Trp Tyr 
    130                 135                 140                 


Asn Phe Thr Pro Leu Ala Arg His Arg Thr Leu Thr Ala Glu Glu Ala 
145                 150                 155                 160 


Glu Glu Glu Trp Glu Arg Arg Asn Lys Val Leu Asn His Phe Ser Ile 
                165                 170                 175     


Met Gln Gln Arg Arg Leu Lys Asp Gln Asp Gln Asp Glu Asp Glu Glu 
            180                 185                 190         


Glu Lys Glu Lys Arg Gly Arg Arg Lys Ala Ser Glu Leu Arg Ile His 
        195                 200                 205             


Asp Leu Glu Asp Asp Leu Glu Met Ser Ser Asp Ala Ser Asp Ala Ser 
    210                 215                 220                 


Gly Glu Glu Gly Gly Arg Val Pro Lys Ala Lys Lys Lys Ala Pro Leu 
225                 230                 235                 240 


Ala Lys Gly Gly Arg Lys Lys Lys Lys Lys Lys Gly Ser Asp Asp Glu 
                245                 250                 255     


Ala Phe Glu Asp Ser Asp Asp Gly Asp Phe Glu Gly Gln Glu Val Asp 
            260                 265                 270         


Tyr Met Ser Asp Gly Ser Ser Ser Ser Gln Glu Glu Pro Glu Ser Lys 
        275                 280                 285             


Ala Lys Ala Pro Gln Gln Glu Glu Gly Pro Lys Gly Val Asp Glu Gln 
    290                 295                 300                 


Ser Asp Ser Ser Glu Glu Ser Glu Glu Glu Lys Pro Pro Glu Glu Asp 
305                 310                 315                 320 


Lys Glu Glu Glu Glu Glu Lys Lys Ala Pro Thr Pro Gln Glu Lys Lys 
                325                 330                 335     


Arg Arg Lys Asp Ser Ser Glu Glu Ser Asp Ser Ser Glu Glu Ser Asp 
            340                 345                 350         


Ile Asp Ser Glu Ala Ser Ser Ala Leu Phe Met Ala Lys Lys Lys Thr 
        355                 360                 365             


Pro Pro Lys Arg Glu Arg Lys Pro Ser Gly Gly Ser Ser Arg Gly Asn 
    370                 375                 380                 


Ser Arg Pro Gly Thr Pro Ser Ala Glu Gly Gly Ser Thr Ser Ser Thr 
385                 390                 395                 400 


Leu Arg Ala Ala Ala Ser Lys Leu Glu Gln Gly Lys Arg Val Ser Glu 
                405                 410                 415     


Met Pro Ala Ala Lys Arg Leu Arg Leu Asp Thr Gly Pro Gln Ser Leu 
            420                 425                 430         


Ser Gly Lys Ser Thr Pro Gln Pro Pro Ser Gly Lys Thr Thr Pro Asn 
        435                 440                 445             


Ser Gly Asp Val Gln Val Thr Glu Asp Ala Val Arg Arg Tyr Leu Thr 
    450                 455                 460                 


Arg Lys Pro Met Thr Thr Lys Asp Leu Leu Lys Lys Phe Gln Thr Lys 
465                 470                 475                 480 


Lys Thr Gly Leu Ser Ser Glu Gln Thr Val Asn Val Leu Ala Gln Ile 
                485                 490                 495     


Leu Lys Arg Leu Asn Pro Glu Arg Lys Met Ile Asn Asp Lys Met His 
            500                 505                 510         


Phe Ser Leu Lys Glu 
        515         


<210>  4791
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2F2__Homo_sapiens__NP_004119

<400>  4791

Met Ala Glu Arg Gly Glu Leu Asp Leu Thr Gly Ala Lys Gln Asn Thr 
1               5                   10                  15      


Gly Val Trp Leu Val Lys Val Pro Lys Tyr Leu Ser Gln Gln Trp Ala 
            20                  25                  30          


Lys Ala Ser Gly Arg Gly Glu Val Gly Lys Leu Arg Ile Ala Lys Thr 
        35                  40                  45              


Gln Gly Arg Thr Glu Val Ser Phe Thr Leu Asn Glu Asp Leu Ala Asn 
    50                  55                  60                  


Ile His Asp Ile Gly Gly Lys Pro Ala Ser Val Ser Ala Pro Arg Glu 
65                  70                  75                  80  


His Pro Phe Val Leu Gln Ser Val Gly Gly Gln Thr Leu Thr Val Phe 
                85                  90                  95      


Thr Glu Ser Ser Ser Asp Lys Leu Ser Leu Glu Gly Ile Val Val Gln 
            100                 105                 110         


Arg Ala Glu Cys Arg Pro Ala Ala Ser Glu Asn Tyr Met Arg Leu Lys 
        115                 120                 125             


Arg Leu Gln Ile Glu Glu Ser Ser Lys Pro Val Arg Leu Ser Gln Gln 
    130                 135                 140                 


Leu Asp Lys Val Val Thr Thr Asn Tyr Lys Pro Val Ala Asn His Gln 
145                 150                 155                 160 


Tyr Asn Ile Glu Tyr Glu Arg Lys Lys Lys Glu Asp Gly Lys Arg Ala 
                165                 170                 175     


Arg Ala Asp Lys Gln His Val Leu Asp Met Leu Phe Ser Ala Phe Glu 
            180                 185                 190         


Lys His Gln Tyr Tyr Asn Leu Lys Asp Leu Val Asp Ile Thr Lys Gln 
        195                 200                 205             


Pro Val Val Tyr Leu Lys Glu Ile Leu Lys Glu Ile Gly Val Gln Asn 
    210                 215                 220                 


Val Lys Gly Ile His Lys Asn Thr Trp Glu Leu Lys Pro Glu Tyr Arg 
225                 230                 235                 240 


His Tyr Gln Gly Glu Glu Lys Ser Asp 
                245                 


<210>  4792
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2H1__Homo_sapiens__NP_001135779

<400>  4792

Met Ala Thr Ser Ser Glu Glu Val Leu Leu Ile Val Lys Lys Val Arg 
1               5                   10                  15      


Gln Lys Lys Gln Asp Gly Ala Leu Tyr Leu Met Ala Glu Arg Ile Ala 
            20                  25                  30          


Trp Ala Pro Glu Gly Lys Asp Arg Phe Thr Ile Ser His Met Tyr Ala 
        35                  40                  45              


Asp Ile Lys Cys Gln Lys Ile Ser Pro Glu Gly Lys Ala Lys Ile Gln 
    50                  55                  60                  


Leu Gln Leu Val Leu His Ala Gly Asp Thr Thr Asn Phe His Phe Ser 
65                  70                  75                  80  


Asn Glu Ser Thr Ala Val Lys Glu Arg Asp Ala Val Lys Asp Leu Leu 
                85                  90                  95      


Gln Gln Leu Leu Pro Lys Phe Lys Arg Lys Ala Asn Lys Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Arg Met Leu Gln Glu Asp Pro Val Leu Phe Gln Leu Tyr 
        115                 120                 125             


Lys Asp Leu Val Val Ser Gln Val Ile Ser Ala Glu Glu Phe Trp Ala 
    130                 135                 140                 


Asn Arg Leu Asn Val Asn Ala Thr Asp Ser Ser Ser Thr Ser Asn His 
145                 150                 155                 160 


Lys Gln Asp Val Gly Ile Ser Ala Ala Phe Leu Ala Asp Val Arg Pro 
                165                 170                 175     


Gln Thr Asp Gly Cys Asn Gly Leu Arg Tyr Asn Leu Thr Ser Asp Ile 
            180                 185                 190         


Ile Glu Ser Ile Phe Arg Thr Tyr Pro Ala Val Lys Met Lys Tyr Ala 
        195                 200                 205             


Glu Asn Val Pro His Asn Met Thr Glu Lys Glu Phe Trp Thr Arg Phe 
    210                 215                 220                 


Phe Gln Ser His Tyr Phe His Arg Asp Arg Leu Asn Thr Gly Ser Lys 
225                 230                 235                 240 


Asp Leu Phe Ala Glu Cys Ala Lys Ile Asp Glu Lys Gly Leu Lys Thr 
                245                 250                 255     


Met Val Ser Leu Gly Val Lys Asn Pro Leu Leu Asp Leu Thr Ala Leu 
            260                 265                 270         


Glu Asp Lys Pro Leu Asp Glu Gly Tyr Gly Ile Ser Ser Val Pro Ser 
        275                 280                 285             


Ala Ser Asn Ser Lys Ser Ile Lys Glu Asn Ser Asn Ala Ala Ile Ile 
    290                 295                 300                 


Lys Arg Phe Asn His His Ser Ala Met Val Leu Ala Ala Gly Leu Arg 
305                 310                 315                 320 


Lys Gln Glu Ala Gln Asn Glu Gln Thr Ser Glu Pro Ser Asn Met Asp 
                325                 330                 335     


Gly Asn Ser Gly Asp Ala Asp Cys Phe Gln Pro Ala Val Lys Arg Ala 
            340                 345                 350         


Lys Leu Gln Glu Ser Ile Glu Tyr Glu Asp Leu Gly Lys Asn Asn Ser 
        355                 360                 365             


Val Lys Thr Ile Ala Leu Asn Leu Lys Lys Ser Asp Arg Tyr Tyr His 
    370                 375                 380                 


Gly Pro Thr Pro Ile Gln Ser Leu Gln Tyr Ala Thr Ser Gln Asp Ile 
385                 390                 395                 400 


Ile Asn Ser Phe Gln Ser Ile Arg Gln Glu Met Glu Ala Tyr Thr Pro 
                405                 410                 415     


Lys Leu Thr Gln Val Leu Ser Ser Ser Ala Ala Ser Ser Thr Ile Thr 
            420                 425                 430         


Ala Leu Ser Pro Gly Gly Ala Leu Met Gln Gly Gly Thr Gln Gln Ala 
        435                 440                 445             


Ile Asn Gln Met Val Pro Asn Asp Ile Gln Ser Glu Leu Lys His Leu 
    450                 455                 460                 


Tyr Val Ala Val Gly Glu Leu Leu Arg His Phe Trp Ser Cys Phe Pro 
465                 470                 475                 480 


Val Asn Thr Pro Phe Leu Glu Glu Lys Val Val Lys Met Lys Ser Asn 
                485                 490                 495     


Leu Glu Arg Phe Gln Val Thr Lys Leu Cys Pro Phe Gln Glu Lys Ile 
            500                 505                 510         


Arg Arg Gln Tyr Leu Ser Thr Asn Leu Val Ser His Ile Glu Glu Met 
        515                 520                 525             


Leu Gln Thr Ala Tyr Asn Lys Leu His Thr Trp Gln Ser Arg Arg Leu 
    530                 535                 540                 


Met Lys Lys Thr 
545             


<210>  4793
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2H2C_2__Homo_sapiens__NP_001035955

<400>  4793

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Glu Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Met Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Leu Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4794
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2H2C__Homo_sapiens__XP_005248650

<400>  4794

Met Arg His Leu Tyr Val Val Val Asp Gly Ser Arg Thr Met Glu Asp 
1               5                   10                  15      


Gln Asp Leu Lys Pro Asn Arg Leu Thr Cys Thr Leu Lys Leu Leu Glu 
            20                  25                  30          


Tyr Phe Val Glu Glu Tyr Phe Asp Gln Asn Pro Ile Ser Gln Ile Gly 
        35                  40                  45              


Ile Ile Val Thr Lys Ser Lys Arg Ala Glu Lys Leu Thr Glu Leu Ser 
    50                  55                  60                  


Gly Asn Pro Arg Lys His Ile Thr Ser Leu Lys Glu Ala Val Asp Met 
65                  70                  75                  80  


Thr Cys His Gly Glu Pro Ser Leu Tyr Asn Ser Leu Ser Met Ala Met 
                85                  90                  95      


Gln Thr Leu Lys His Met Pro Gly His Thr Ser Arg Glu Val Leu Ile 
            100                 105                 110         


Ile Phe Ser Ser Leu Thr Thr Cys Asp Pro Ser Asn Ile Tyr Asp Leu 
        115                 120                 125             


Ile Lys Thr Leu Lys Ala Ala Lys Ile Arg Val Ser Val Ile Gly Leu 
    130                 135                 140                 


Ser Ala Glu Val Arg Val Cys Thr Val Leu Ala Arg Glu Thr Gly Gly 
145                 150                 155                 160 


Thr Tyr His Val Ile Leu Asp Glu Ser His Tyr Lys Glu Leu Leu Thr 
                165                 170                 175     


His His Leu Ser Pro Pro Pro Ala Ser Ser Ser Ser Glu Cys Ser Leu 
            180                 185                 190         


Ile Arg Met Gly Phe Pro Gln His Thr Ile Ala Ser Leu Ser Asp Gln 
        195                 200                 205             


Asp Ala Lys Pro Ser Phe Ser Met Ala His Leu Asp Gly Asn Thr Glu 
    210                 215                 220                 


Pro Gly Leu Thr Leu Gly Gly Tyr Phe Cys Pro Gln Cys Arg Ala Lys 
225                 230                 235                 240 


Tyr Cys Glu Leu Pro Val Glu Cys Lys Ile Cys Gly Leu Thr Leu Val 
                245                 250                 255     


Ser Ala Pro His Leu Ala Arg Ser Tyr His His Leu Phe Pro Leu Asp 
            260                 265                 270         


Ala Phe Gln Glu Ile Pro Leu Glu Glu Tyr Asn Gly Glu Arg Phe Cys 
        275                 280                 285             


Tyr Gly Cys Gln Gly Glu Leu Lys Asp Gln His Val Tyr Val Cys Ala 
    290                 295                 300                 


Val Cys Gln Asn Val Phe Cys Val Asp Cys Asp Val Phe Val His Asp 
305                 310                 315                 320 


Ser Leu His Cys Cys Pro Gly Cys Ile His Lys Ile Pro Ala Pro Ser 
                325                 330                 335     


Gly Val 
        


<210>  4795
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2H2__Homo_sapiens__NP_001506

<400>  4795

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Ile Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  4796
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2H3__Homo_sapiens__NP_001258796

<400>  4796

Met Val Leu Gly Asn Ser His Leu Phe Met Asn Arg Ser Asn Lys Leu 
1               5                   10                  15      


Ala Val Ile Ala Ser His Ile Gln Glu Ser Arg Phe Leu Tyr Pro Gly 
            20                  25                  30          


Lys Asn Gly Arg Leu Gly Asp Phe Phe Gly Asp Pro Gly Asn Pro Pro 
        35                  40                  45              


Glu Phe Asn Pro Ser Gly Ser Lys Asp Gly Lys Tyr Glu Leu Leu Thr 
    50                  55                  60                  


Ser Ala Asn Glu Val Ile Val Glu Glu Ile Lys Asp Leu Met Thr Lys 
65                  70                  75                  80  


Ser Asp Ile Lys Gly Gln His Thr Glu Thr Leu Leu Ala Gly Ser Leu 
                85                  90                  95      


Ala Lys Ala Leu Cys Tyr Ile His Arg Met Asn Lys Glu Val Lys Asp 
            100                 105                 110         


Asn Gln Glu Met Lys Ser Arg Ile Leu Val Ile Lys Ala Ala Glu Asp 
        115                 120                 125             


Ser Ala Leu Gln Tyr Met Asn Phe Met Asn Val Ile Phe Ala Ala Gln 
    130                 135                 140                 


Lys Gln Asn Ile Leu Ile Asp Ala Cys Val Leu Asp Ser Asp Ser Gly 
145                 150                 155                 160 


Leu Leu Gln Gln Ala Cys Asp Ile Thr Gly Gly Leu Tyr Leu Lys Val 
                165                 170                 175     


Pro Gln Met Pro Ser Leu Leu Gln Tyr Leu Leu Trp Val Phe Leu Pro 
            180                 185                 190         


Asp Gln Asp Gln Arg Ser Gln Leu Ile Leu Pro Pro Pro Val His Val 
        195                 200                 205             


Asp Tyr Arg Ala Ala Cys Phe Cys His Arg Asn Leu Ile Glu Ile Gly 
    210                 215                 220                 


Tyr Val Cys Ser Val Cys Leu Ser Ile Phe Cys Asn Phe Ser Pro Ile 
225                 230                 235                 240 


Cys Thr Thr Cys Glu Thr Ala Phe Lys Ile Ser Leu Pro Pro Val Leu 
                245                 250                 255     


Lys Ala Lys Lys Lys Lys Leu Lys Val Ser Ala 
            260                 265         


<210>  4797
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2H4__Homo_sapiens__NP_001508

<400>  4797

Met Glu Ser Thr Pro Ser Arg Gly Leu Asn Arg Val His Leu Gln Cys 
1               5                   10                  15      


Arg Asn Leu Gln Glu Phe Leu Gly Gly Leu Ser Pro Gly Val Leu Asp 
            20                  25                  30          


Arg Leu Tyr Gly His Pro Ala Thr Cys Leu Ala Val Phe Arg Glu Leu 
        35                  40                  45              


Pro Ser Leu Ala Lys Asn Trp Val Met Arg Met Leu Phe Leu Glu Gln 
    50                  55                  60                  


Pro Leu Pro Gln Ala Ala Val Ala Leu Trp Val Lys Lys Glu Phe Ser 
65                  70                  75                  80  


Lys Ala Gln Glu Glu Ser Thr Gly Leu Leu Ser Gly Leu Arg Ile Trp 
                85                  90                  95      


His Thr Gln Leu Leu Pro Gly Gly Leu Gln Gly Leu Ile Leu Asn Pro 
            100                 105                 110         


Ile Phe Arg Gln Asn Leu Arg Ile Ala Leu Leu Gly Gly Gly Lys Ala 
        115                 120                 125             


Trp Ser Asp Asp Thr Ser Gln Leu Gly Pro Asp Lys His Ala Arg Asp 
    130                 135                 140                 


Val Pro Ser Leu Asp Lys Tyr Ala Glu Glu Arg Trp Glu Val Val Leu 
145                 150                 155                 160 


His Phe Met Val Gly Ser Pro Ser Ala Ala Val Ser Gln Asp Leu Ala 
                165                 170                 175     


Gln Leu Leu Ser Gln Ala Gly Leu Met Lys Ser Thr Glu Pro Gly Glu 
            180                 185                 190         


Pro Pro Cys Ile Thr Ser Ala Gly Phe Gln Phe Leu Leu Leu Asp Thr 
        195                 200                 205             


Pro Ala Gln Leu Trp Tyr Phe Met Leu Gln Tyr Leu Gln Thr Ala Gln 
    210                 215                 220                 


Ser Arg Gly Met Asp Leu Val Glu Ile Leu Ser Phe Leu Phe Gln Leu 
225                 230                 235                 240 


Ser Phe Ser Thr Leu Gly Lys Asp Tyr Ser Val Glu Gly Met Ser Asp 
                245                 250                 255     


Ser Leu Leu Asn Phe Leu Gln His Leu Arg Glu Phe Gly Leu Val Phe 
            260                 265                 270         


Gln Arg Lys Arg Lys Ser Arg Arg Tyr Tyr Pro Thr Arg Leu Ala Ile 
        275                 280                 285             


Asn Leu Ser Ser Gly Val Ser Gly Ala Gly Gly Thr Val His Gln Pro 
    290                 295                 300                 


Gly Phe Ile Val Val Glu Thr Asn Tyr Arg Leu Tyr Ala Tyr Thr Glu 
305                 310                 315                 320 


Ser Glu Leu Gln Ile Ala Leu Ile Ala Leu Phe Ser Glu Met Leu Tyr 
                325                 330                 335     


Arg Phe Pro Asn Met Val Val Ala Gln Val Thr Arg Glu Ser Val Gln 
            340                 345                 350         


Gln Ala Ile Ala Ser Gly Ile Thr Ala Gln Gln Ile Ile His Phe Leu 
        355                 360                 365             


Arg Thr Arg Ala His Pro Val Met Leu Lys Gln Thr Pro Val Leu Pro 
    370                 375                 380                 


Pro Thr Ile Thr Asp Gln Ile Arg Leu Trp Glu Leu Glu Arg Asp Arg 
385                 390                 395                 400 


Leu Arg Phe Thr Glu Gly Val Leu Tyr Asn Gln Phe Leu Ser Gln Val 
                405                 410                 415     


Asp Phe Glu Leu Leu Leu Ala His Ala Arg Glu Leu Gly Val Leu Val 
            420                 425                 430         


Phe Glu Asn Ser Ala Lys Arg Leu Met Val Val Thr Pro Ala Gly His 
        435                 440                 445             


Ser Asp Val Lys Arg Phe Trp Lys Arg Gln Lys His Ser Ser 
    450                 455                 460         


<210>  4798
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2H5__Homo_sapiens__NP_997001

<400>  4798

Met Val Asn Val Leu Lys Gly Val Leu Ile Glu Cys Asp Pro Ala Met 
1               5                   10                  15      


Lys Gln Phe Leu Leu Tyr Leu Asp Glu Ser Asn Ala Leu Gly Lys Lys 
            20                  25                  30          


Phe Ile Ile Gln Asp Ile Asp Asp Thr His Val Phe Val Ile Ala Glu 
        35                  40                  45              


Leu Val Asn Val Leu Gln Glu Arg Val Gly Glu Leu Met Asp Gln Asn 
    50                  55                  60                  


Ala Phe Ser Leu Thr Gln Lys 
65                  70      


<210>  4799
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2I__Homo_sapiens__NP_001267729

<400>  4799

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15      


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30          


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45              


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60                  


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80  


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95      


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110         


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125             


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140                 


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160 


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175     


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190         


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205             


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220                 


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240 


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255     


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270         


Glu Gly 
        


<210>  4800
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2IRD1__Homo_sapiens__NP_001186136

<400>  4800

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly 
1               5                   10                  15      


Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr 
            20                  25                  30          


Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu 
        35                  40                  45              


Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val 
    50                  55                  60                  


Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 
65                  70                  75                  80  


Gln Ser Asp Phe Leu Arg Phe Cys Leu Ser Ala Ala Gln His Arg Ala 
                85                  90                  95      


Ala Thr Ser Gln Leu Glu Gly Arg Val Val Arg Arg Val Leu Thr Val 
            100                 105                 110         


Ala Ser Arg Ala Leu Cys Pro Thr Gly Gly Pro Pro Trp Lys Asp Pro 
        115                 120                 125             


Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg 
    130                 135                 140                 


Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu 
145                 150                 155                 160 


Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu 
                165                 170                 175     


Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 
            180                 185                 190         


Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg 
        195                 200                 205             


Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His 
    210                 215                 220                 


Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly 
225                 230                 235                 240 


Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro 
                245                 250                 255     


Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro 
            260                 265                 270         


Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe 
        275                 280                 285             


Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln 
    290                 295                 300                 


Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg 
305                 310                 315                 320 


Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys 
                325                 330                 335     


Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val 
            340                 345                 350         


His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu 
        355                 360                 365             


Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg 
    370                 375                 380                 


Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly 
385                 390                 395                 400 


Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro 
                405                 410                 415     


Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg 
            420                 425                 430         


Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg 
        435                 440                 445             


His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe 
    450                 455                 460                 


Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser 
465                 470                 475                 480 


Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp 
                485                 490                 495     


Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 
            500                 505                 510         


Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile 
        515                 520                 525             


Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser 
    530                 535                 540                 


Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser 
545                 550                 555                 560 


Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser 
                565                 570                 575     


Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 
            580                 585                 590         


Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg 
        595                 600                 605             


Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser 
    610                 615                 620                 


Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 
625                 630                 635                 640 


Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg 
                645                 650                 655     


Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro 
            660                 665                 670         


Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Met Asp Ser Gln Glu 
        675                 680                 685             


Arg Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly 
    690                 695                 700                 


Phe Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn 
705                 710                 715                 720 


Thr Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu 
                725                 730                 735     


Ala Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys 
            740                 745                 750         


Ser Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro 
        755                 760                 765             


Phe Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu 
    770                 775                 780                 


Ala Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly 
785                 790                 795                 800 


Leu Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys 
                805                 810                 815     


Val Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly 
            820                 825                 830         


Glu Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile 
        835                 840                 845             


Arg Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile 
    850                 855                 860                 


Pro Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile 
865                 870                 875                 880 


Leu Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln 
                885                 890                 895     


Pro Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser 
            900                 905                 910         


Ser Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val 
        915                 920                 925             


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser 
    930                 935                 940                 


Val Ala Ser Ala Asn Gln Ile Ser Leu Val Gln Trp Pro Met Tyr Met 
945                 950                 955                 960 


Val Asp Tyr Ala Gly Leu Asn Val Gln Leu Pro Gly Pro Leu Asn Tyr 
                965                 970                 975     


<210>  4801
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF2IRD2__Homo_sapiens__NP_775808

<400>  4801

Met Ala Gln Val Ala Val Ser Thr Leu Pro Val Glu Glu Glu Ser Ser 
1               5                   10                  15      


Ser Glu Thr Arg Met Val Val Thr Phe Leu Val Ser Ala Leu Glu Ser 
            20                  25                  30          


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45              


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Cys Ala 
    50                  55                  60                  


Phe Val Asn Ala Arg Thr Asp Phe Gln Lys Asp Phe Ala Lys Tyr Cys 
65                  70                  75                  80  


Val Ala Glu Gly Leu Cys Glu Val Lys Pro Pro Cys Pro Val Asn Gly 
                85                  90                  95      


Met Gln Val His Ser Gly Glu Thr Glu Ile Leu Arg Lys Ala Val Glu 
            100                 105                 110         


Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Thr Thr Val Met 
        115                 120                 125             


Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val 
    130                 135                 140                 


Val Gln Gly Leu Pro Glu Gly Val Ala Phe Gln His Pro Glu Asn Tyr 
145                 150                 155                 160 


Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser 
                165                 170                 175     


Phe Ile Ile Asn Arg Pro Phe Leu Gly Pro Glu Ser Gln Leu Gly Gly 
            180                 185                 190         


Pro Gly Met Val Thr Asp Ala Glu Arg Ser Ile Val Ser Pro Ser Glu 
        195                 200                 205             


Ser Cys Gly Pro Ile Asn Val Lys Thr Glu Pro Met Glu Asp Ser Gly 
    210                 215                 220                 


Ile Ser Leu Lys Ala Glu Ala Val Ser Val Lys Lys Glu Ser Glu Asp 
225                 230                 235                 240 


Pro Asn Tyr Tyr Gln Tyr Asn Met Gln Gly Ser His Pro Ser Ser Thr 
                245                 250                 255     


Ser Asn Glu Val Ile Glu Met Glu Leu Pro Met Glu Asp Ser Thr Pro 
            260                 265                 270         


Leu Val Pro Ser Glu Glu Pro Asn Glu Asp Pro Glu Ala Glu Val Lys 
        275                 280                 285             


Ile Glu Gly Asn Thr Asn Ser Ser Ser Val Thr Asn Ser Ala Ala Gly 
    290                 295                 300                 


Val Glu Asp Leu Asn Ile Val Gln Val Thr Val Pro Asp Asn Glu Lys 
305                 310                 315                 320 


Glu Arg Leu Ser Ser Ile Glu Lys Ile Lys Gln Leu Arg Glu Gln Val 
                325                 330                 335     


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Val Asp Phe 
            340                 345                 350         


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Phe Asn Pro Gly Cys Val 
        355                 360                 365             


Val Ile Asp Gly Met Pro Pro Gly Val Val Phe Lys Ala Pro Gly Tyr 
    370                 375                 380                 


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Glu Ala Ala Glu Phe Ile 
385                 390                 395                 400 


Lys Phe Thr Val Ile Arg Pro Leu Pro Gly Leu Glu Leu Ser Asn Val 
                405                 410                 415     


Gly Lys Arg Lys Ile Asp Gln Glu Gly Arg Val Phe Gln Glu Lys Trp 
            420                 425                 430         


Glu Arg Ala Tyr Phe Phe Val Glu Val Gln Asn Ile Pro Thr Cys Leu 
        435                 440                 445             


Ile Cys Lys Gln Ser Met Ser Val Ser Lys Glu Tyr Asn Leu Arg Arg 
    450                 455                 460                 


His Tyr Gln Thr Asn His Ser Lys His Tyr Asp Gln Tyr Met Glu Arg 
465                 470                 475                 480 


Met Arg Asp Glu Lys Leu His Glu Leu Lys Lys Gly Leu Arg Lys Tyr 
                485                 490                 495     


Leu Leu Gly Ser Ser Asp Thr Glu Cys Pro Glu Gln Lys Gln Val Phe 
            500                 505                 510         


Ala Asn Pro Ser Pro Thr Gln Lys Ser Pro Val Gln Pro Val Glu Asp 
        515                 520                 525             


Leu Ala Gly Asn Leu Trp Glu Lys Leu Arg Glu Lys Ile Arg Ser Phe 
    530                 535                 540                 


Val Ala Tyr Ser Ile Ala Ile Asp Glu Ile Thr Asp Ile Asn Asn Thr 
545                 550                 555                 560 


Thr Gln Leu Ala Ile Phe Ile Arg Gly Val Asp Glu Asn Phe Asp Val 
                565                 570                 575     


Ser Glu Glu Leu Leu Asp Thr Val Pro Met Thr Gly Thr Lys Ser Gly 
            580                 585                 590         


Asn Glu Ile Phe Ser Arg Val Glu Lys Ser Leu Lys Lys Phe Cys Ile 
        595                 600                 605             


Asp Trp Ser Lys Leu Val Ser Val Ala Ser Thr Gly Thr Pro Ala Met 
    610                 615                 620                 


Val Asp Ala Asn Asn Gly Leu Val Thr Lys Leu Lys Ser Arg Val Ala 
625                 630                 635                 640 


Thr Phe Cys Lys Gly Ala Glu Leu Lys Ser Ile Cys Cys Ile Ile His 
                645                 650                 655     


Pro Glu Ser Leu Cys Ala Gln Lys Leu Lys Met Asp His Val Met Asp 
            660                 665                 670         


Val Val Val Lys Ser Val Asn Trp Ile Cys Ser Arg Gly Leu Asn His 
        675                 680                 685             


Ser Glu Phe Thr Thr Leu Leu Tyr Glu Leu Asp Ser Gln Tyr Gly Ser 
    690                 695                 700                 


Leu Leu Tyr Tyr Thr Glu Ile Lys Trp Leu Ser Arg Gly Leu Val Leu 
705                 710                 715                 720 


Lys Arg Phe Phe Glu Ser Leu Glu Glu Ile Asp Ser Phe Met Ser Ser 
                725                 730                 735     


Arg Gly Lys Pro Leu Pro Gln Leu Ser Ser Ile Asp Trp Ile Arg Asp 
            740                 745                 750         


Leu Ala Phe Leu Val Asp Met Thr Met His Leu Asn Ala Leu Asn Ile 
        755                 760                 765             


Ser Leu Gln Gly His Ser Gln Ile Val Thr Gln Met Tyr Asp Leu Ile 
    770                 775                 780                 


Arg Ala Phe Leu Ala Lys Leu Cys Leu Trp Glu Thr His Leu Thr Arg 
785                 790                 795                 800 


Asn Asn Leu Ala His Phe Pro Thr Leu Lys Leu Ala Ser Arg Asn Glu 
                805                 810                 815     


Ser Asp Gly Leu Asn Tyr Ile Pro Lys Ile Ala Glu Leu Lys Thr Glu 
            820                 825                 830         


Phe Gln Lys Arg Leu Ser Asp Phe Lys Leu Tyr Glu Ser Glu Leu Thr 
        835                 840                 845             


Leu Phe Ser Ser Pro Phe Ser Thr Lys Ile Asp Ser Val His Glu Glu 
    850                 855                 860                 


Leu Gln Met Glu Val Ile Asp Leu Gln Cys Asn Thr Val Leu Lys Thr 
865                 870                 875                 880 


Lys Tyr Asp Lys Val Gly Ile Pro Glu Phe Tyr Lys Tyr Leu Trp Gly 
                885                 890                 895     


Ser Tyr Pro Lys Tyr Lys His His Cys Ala Lys Ile Leu Ser Met Phe 
            900                 905                 910         


Gly Ser Thr Tyr Ile Cys Glu Gln Leu Phe Ser Ile Met Lys Leu Ser 
        915                 920                 925             


Lys Thr Lys Tyr Cys Ser Gln Leu Lys Asp Ser Gln Trp Asp Ser Val 
    930                 935                 940                 


Leu His Ile Ala Thr 
945                 


<210>  4802
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF3A__Homo_sapiens__NP_002088

<400>  4802

Met Asp Pro Pro Ala Val Val Ala Glu Ser Val Ser Ser Leu Thr Ile 
1               5                   10                  15      


Ala Asp Ala Phe Ile Ala Ala Gly Glu Ser Ser Ala Pro Thr Pro Pro 
            20                  25                  30          


Arg Pro Ala Leu Pro Arg Arg Phe Ile Cys Ser Phe Pro Asp Cys Ser 
        35                  40                  45              


Ala Asn Tyr Ser Lys Ala Trp Lys Leu Asp Ala His Leu Cys Lys His 
    50                  55                  60                  


Thr Gly Glu Arg Pro Phe Val Cys Asp Tyr Glu Gly Cys Gly Lys Ala 
65                  70                  75                  80  


Phe Ile Arg Asp Tyr His Leu Ser Arg His Ile Leu Thr His Thr Gly 
                85                  90                  95      


Glu Lys Pro Phe Val Cys Ala Ala Asn Gly Cys Asp Gln Lys Phe Asn 
            100                 105                 110         


Thr Lys Ser Asn Leu Lys Lys His Phe Glu Arg Lys His Glu Asn Gln 
        115                 120                 125             


Gln Lys Gln Tyr Ile Cys Ser Phe Glu Asp Cys Lys Lys Thr Phe Lys 
    130                 135                 140                 


Lys His Gln Gln Leu Lys Ile His Gln Cys Gln His Thr Asn Glu Pro 
145                 150                 155                 160 


Leu Phe Lys Cys Thr Gln Glu Gly Cys Gly Lys His Phe Ala Ser Pro 
                165                 170                 175     


Ser Lys Leu Lys Arg His Ala Lys Ala His Glu Gly Tyr Val Cys Gln 
            180                 185                 190         


Lys Gly Cys Ser Phe Val Ala Lys Thr Trp Thr Glu Leu Leu Lys His 
        195                 200                 205             


Val Arg Glu Thr His Lys Glu Glu Ile Leu Cys Glu Val Cys Arg Lys 
    210                 215                 220                 


Thr Phe Lys Arg Lys Asp Tyr Leu Lys Gln His Met Lys Thr His Ala 
225                 230                 235                 240 


Pro Glu Arg Asp Val Cys Arg Cys Pro Arg Glu Gly Cys Gly Arg Thr 
                245                 250                 255     


Tyr Thr Thr Val Phe Asn Leu Gln Ser His Ile Leu Ser Phe His Glu 
            260                 265                 270         


Glu Ser Arg Pro Phe Val Cys Glu His Ala Gly Cys Gly Lys Thr Phe 
        275                 280                 285             


Ala Met Lys Gln Ser Leu Thr Arg His Ala Val Val His Asp Pro Asp 
    290                 295                 300                 


Lys Lys Lys Met Lys Leu Lys Val Lys Lys Ser Arg Glu Lys Arg Ser 
305                 310                 315                 320 


Leu Ala Ser His Leu Ser Gly Tyr Ile Pro Pro Lys Arg Lys Gln Gly 
                325                 330                 335     


Gln Gly Leu Ser Leu Cys Gln Asn Gly Glu Ser Pro Asn Cys Val Glu 
            340                 345                 350         


Asp Lys Met Leu Ser Thr Val Ala Val Leu Thr Leu Gly 
        355                 360                 365 


<210>  4803
<211>  2109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTF3C1__Homo_sapiens__NP_001511

<400>  4803

Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val Ala Leu Glu Gly Leu 
1               5                   10                  15      


Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg Leu Glu Thr Arg Val 
            20                  25                  30          


Pro Pro Phe Pro Leu Pro Leu Glu Pro Cys Thr Gln Glu Phe Leu Trp 
        35                  40                  45              


Arg Ala Leu Ala Thr His Pro Gly Ile Ser Phe Tyr Glu Glu Pro Arg 
    50                  55                  60                  


Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr Glu Glu Ile Asp Leu 
65                  70                  75                  80  


Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro Val Ala Leu Glu Asp 
                85                  90                  95      


Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys Asp Gly Ile Gln Gly 
            100                 105                 110         


Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asn Ile Thr Asn Asp Ile Arg 
        115                 120                 125             


Thr Lys Ser Leu Gln Pro Arg Cys Thr Met Val Glu Ala Phe Asp Arg 
    130                 135                 140                 


Trp Gly Lys Lys Leu Ile Ile Val Ala Ser Gln Ala Met Arg Tyr Arg 
145                 150                 155                 160 


Ala Leu Ile Gly Gln Glu Gly Asp Pro Asp Leu Lys Leu Pro Asp Phe 
                165                 170                 175     


Ser Tyr Cys Ile Leu Glu Arg Leu Gly Arg Ser Arg Trp Gln Gly Glu 
            180                 185                 190         


Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys Val Asp Ala Gly Lys 
        195                 200                 205             


Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn Gly Leu Ile Thr Met 
    210                 215                 220                 


Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala Gln Gln His Ser Ile 
225                 230                 235                 240 


Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg Arg Ser Lys Tyr Asp 
                245                 250                 255     


Ile Leu Met Glu Lys Leu Ser Val Met Leu Ser Thr Arg Thr Asn His 
            260                 265                 270         


Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu Gly Leu Cys Glu Arg 
        275                 280                 285             


Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn Ala Gly Leu Ala Lys 
    290                 295                 300                 


Val Val Ser Leu Arg Leu Gln Glu Ile His Pro Glu Cys Gly Pro Cys 
305                 310                 315                 320 


Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg Cys Leu Lys Leu Leu 
                325                 330                 335     


Lys Glu Phe Lys Arg Asn Asp His Asp Asp Asp Glu Asp Glu Glu Val 
            340                 345                 350         


Ile Ser Lys Thr Val Pro Pro Val Asp Ile Val Phe Glu Arg Asp Met 
        355                 360                 365             


Leu Thr Gln Thr Tyr Asp Leu Ile Glu Arg Arg Gly Thr Lys Gly Ile 
    370                 375                 380                 


Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val Gly Lys Leu Glu Ala 
385                 390                 395                 400 


Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys Val Val Lys Gly Phe 
                405                 410                 415     


Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys Tyr Ile Ser Cys Val 
            420                 425                 430         


Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr Gln Arg Glu Lys Ala 
        435                 440                 445             


Arg Ser Glu Leu Leu Thr Thr Val Ser Leu Ala Ser Met Gln Glu Glu 
    450                 455                 460                 


Ser Leu Leu Pro Glu Gly Glu Asp Thr Phe Leu Ser Glu Ser Asp Ser 
465                 470                 475                 480 


Glu Glu Glu Arg Ser Ser Ser Lys Arg Arg Gly Arg Gly Ser Gln Lys 
                485                 490                 495     


Asp Thr Arg Ala Ser Ala Asn Leu Arg Pro Lys Thr Gln Pro His His 
            500                 505                 510         


Ser Thr Pro Thr Lys Gly Gly Trp Lys Val Val Asn Leu His Pro Leu 
        515                 520                 525             


Lys Lys Gln Pro Pro Ser Phe Pro Gly Ala Ala Glu Glu Arg Ala Cys 
    530                 535                 540                 


Gln Ser Leu Ala Ser Arg Asp Ser Leu Leu Asp Thr Ser Ser Val Ser 
545                 550                 555                 560 


Glu Pro Asn Val Ser Phe Val Ser His Cys Ala Asp Ser Asn Ser Gly 
                565                 570                 575     


Asp Ile Ala Val Ile Glu Glu Val Arg Met Glu Asn Pro Lys Glu Ser 
            580                 585                 590         


Ser Ser Ser Leu Lys Thr Gly Arg His Ser Ser Gly Gln Asp Lys Pro 
        595                 600                 605             


His Glu Thr Tyr Arg Leu Leu Lys Arg Arg Asn Leu Ile Ile Glu Ala 
    610                 615                 620                 


Val Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe Thr Ile Gln Lys Met 
625                 630                 635                 640 


Ile Met Asp Gln Glu Lys Gln Glu Gly Val Ser Thr Lys Cys Cys Lys 
                645                 650                 655     


Lys Ser Ile Val Arg Leu Val Arg Asn Leu Ser Glu Glu Gly Leu Leu 
            660                 665                 670         


Arg Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly Ile Lys Lys Lys Val 
        675                 680                 685             


Asp Leu Val Val His Pro Ser Met Asp Gln Asn Asp Pro Leu Val Arg 
    690                 695                 700                 


Ser Ala Ile Glu Gln Val Arg Phe Arg Ile Ser Asn Ser Ser Thr Ala 
705                 710                 715                 720 


Asn Arg Val Lys Thr Ser Gln Pro Pro Val Pro Gln Gly Glu Ala Glu 
                725                 730                 735     


Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser Gly Ser Gly Asp Ser Gln 
            740                 745                 750         


Leu Ser Ala Ser Ser Arg Ser Glu Ser Gly Arg Met Lys Lys Ser Asp 
        755                 760                 765             


Asn Lys Met Gly Ile Thr Pro Leu Arg Asn Tyr His Pro Ile Val Val 
    770                 775                 780                 


Pro Gly Leu Gly Arg Ser Leu Gly Phe Leu Pro Lys Met Pro Arg Leu 
785                 790                 795                 800 


Arg Val Val His Met Phe Leu Trp Tyr Leu Ile Tyr Gly His Pro Ala 
                805                 810                 815     


Ser Asn Thr Val Glu Lys Pro Ser Phe Ile Ser Glu Arg Arg Thr Ile 
            820                 825                 830         


Lys Gln Glu Ser Gly Arg Ala Gly Val Arg Pro Ser Ser Ser Gly Ser 
        835                 840                 845             


Ala Trp Glu Ala Cys Ser Glu Ala Pro Ser Lys Gly Ser Gln Asp Gly 
    850                 855                 860                 


Val Thr Trp Glu Ala Glu Val Glu Leu Ala Thr Glu Thr Val Tyr Val 
865                 870                 875                 880 


Asp Asp Ala Ser Trp Met Arg Tyr Ile Pro Pro Ile Pro Val His Arg 
                885                 890                 895     


Asp Phe Gly Phe Gly Trp Ala Leu Val Ser Asp Ile Leu Leu Cys Leu 
            900                 905                 910         


Pro Leu Ser Ile Phe Ile Gln Ile Val Gln Val Ser Tyr Lys Val Asp 
        915                 920                 925             


Asn Leu Glu Glu Phe Leu Asn Asp Pro Leu Lys Lys His Thr Leu Ile 
    930                 935                 940                 


Arg Phe Leu Pro Arg Pro Ile Arg Gln Gln Leu Leu Tyr Lys Arg Arg 
945                 950                 955                 960 


Tyr Ile Phe Ser Val Val Glu Asn Leu Gln Arg Leu Cys Tyr Met Gly 
                965                 970                 975     


Leu Leu Gln Phe Gly Pro Thr Glu Lys Phe Gln Asp Lys Asp Gln Val 
            980                 985                 990         


Phe Ile Phe Leu Lys Lys Asn Ala  Val Ile Val Asp Thr  Thr Ile Cys 
        995                 1000                 1005             


Asp Pro  His Tyr Asn Leu Ala  Arg Ser Ser Arg Pro  Phe Glu Arg 
    1010                 1015                 1020             


Arg Leu  Tyr Val Leu Asn Ser  Met Gln Asp Val Glu  Asn Tyr Trp 
    1025                 1030                 1035             


Phe Asp  Leu Gln Cys Val Cys  Leu Asn Thr Pro Leu  Gly Val Val 
    1040                 1045                 1050             


Arg Cys  Pro Arg Val Arg Lys  Asn Ser Ser Thr Asp  Gln Gly Ser 
    1055                 1060                 1065             


Asp Glu  Glu Gly Ser Leu Gln  Lys Glu Gln Glu Ser  Ala Met Asp 
    1070                 1075                 1080             


Lys His  Asn Leu Glu Arg Lys  Cys Ala Met Leu Glu  Tyr Thr Thr 
    1085                 1090                 1095             


Gly Ser  Arg Glu Val Val Asp  Glu Gly Leu Ile Pro  Gly Asp Gly 
    1100                 1105                 1110             


Leu Gly  Ala Ala Gly Leu Asp  Ser Ser Phe Tyr Gly  His Leu Lys 
    1115                 1120                 1125             


Arg Asn  Trp Ile Trp Thr Ser  Tyr Ile Ile Asn Gln  Ala Lys Lys 
    1130                 1135                 1140             


Glu Asn  Thr Ala Ala Glu Asn  Gly Leu Thr Val Arg  Leu Gln Thr 
    1145                 1150                 1155             


Phe Leu  Ser Lys Arg Pro Met  Pro Leu Ser Ala Arg  Gly Asn Ser 
    1160                 1165                 1170             


Arg Leu  Asn Ile Trp Gly Glu  Ala Arg Val Gly Ser  Glu Leu Cys 
    1175                 1180                 1185             


Ala Gly  Trp Glu Glu Gln Phe  Glu Val Asp Arg Glu  Pro Ser Leu 
    1190                 1195                 1200             


Asp Arg  Asn Arg Arg Val Arg  Gly Gly Lys Ser Gln  Lys Arg Lys 
    1205                 1210                 1215             


Arg Leu  Lys Lys Asp Pro Gly  Lys Lys Ile Lys Arg  Lys Lys Lys 
    1220                 1225                 1230             


Gly Glu  Phe Pro Gly Glu Lys  Ser Lys Arg Leu Arg  Tyr His Asp 
    1235                 1240                 1245             


Glu Ala  Asp Gln Ser Ala Leu  Gln Arg Met Thr Arg  Leu Arg Val 
    1250                 1255                 1260             


Thr Trp  Ser Met Gln Glu Asp  Gly Leu Leu Val Leu  Cys Arg Ile 
    1265                 1270                 1275             


Ala Ser  Asn Val Leu Asn Thr  Lys Val Lys Gly Pro  Phe Val Thr 
    1280                 1285                 1290             


Trp Gln  Val Val Arg Asp Ile  Leu His Ala Thr Phe  Glu Glu Ser 
    1295                 1300                 1305             


Leu Asp  Lys Thr Ser His Ser  Val Gly Arg Arg Ala  Arg Tyr Ile 
    1310                 1315                 1320             


Val Lys  Asn Pro Gln Ala Tyr  Leu Asn Tyr Lys Val  Cys Leu Ala 
    1325                 1330                 1335             


Glu Val  Tyr Gln Asp Lys Ala  Leu Val Gly Asp Phe  Met Asn Arg 
    1340                 1345                 1350             


Arg Gly  Asp Tyr Asp Asp Pro  Lys Val Cys Ala Asn  Glu Phe Lys 
    1355                 1360                 1365             


Glu Phe  Val Glu Lys Leu Lys  Glu Lys Phe Ser Ser  Ala Leu Arg 
    1370                 1375                 1380             


Asn Ser  Asn Leu Glu Ile Pro  Asp Thr Leu Gln Glu  Leu Phe Ala 
    1385                 1390                 1395             


Arg Tyr  Arg Val Leu Ala Ile  Gly Asp Glu Lys Asp  Gln Thr Arg 
    1400                 1405                 1410             


Lys Glu  Asp Glu Leu Asn Ser  Val Asp Asp Ile His  Phe Leu Val 
    1415                 1420                 1425             


Leu Gln  Asn Leu Ile Gln Ser  Thr Leu Ala Leu Ser  Asp Ser Gln 
    1430                 1435                 1440             


Met Lys  Ser Tyr Gln Ser Phe  Gln Thr Phe Arg Leu  Tyr Arg Glu 
    1445                 1450                 1455             


Tyr Lys  Asp His Val Leu Val  Lys Ala Phe Met Glu  Cys Gln Lys 
    1460                 1465                 1470             


Arg Ser  Leu Val Asn Arg Arg  Arg Val Asn His Thr  Leu Gly Pro 
    1475                 1480                 1485             


Lys Lys  Asn Arg Ala Leu Pro  Phe Val Pro Met Ser  Tyr Gln Leu 
    1490                 1495                 1500             


Ser Gln  Thr Tyr Tyr Arg Ile  Phe Thr Trp Arg Phe  Pro Ser Thr 
    1505                 1510                 1515             


Ile Cys  Thr Glu Ser Phe Gln  Phe Leu Asp Arg Met  Arg Ala Ala 
    1520                 1525                 1530             


Gly Lys  Leu Asp Gln Pro Asp  Arg Phe Ser Phe Lys  Asp Gln Asp 
    1535                 1540                 1545             


Asn Asn  Glu Pro Thr Asn Asp  Met Val Ala Phe Ser  Leu Asp Gly 
    1550                 1555                 1560             


Pro Gly  Gly Asn Cys Val Ala  Val Leu Thr Leu Phe  Ser Leu Gly 
    1565                 1570                 1575             


Leu Ile  Ser Val Asp Val Arg  Ile Pro Glu Gln Ile  Ile Val Val 
    1580                 1585                 1590             


Asp Ser  Ser Met Val Glu Asn  Glu Val Ile Lys Ser  Leu Gly Lys 
    1595                 1600                 1605             


Asp Gly  Ser Leu Glu Asp Asp  Glu Asp Glu Glu Asp  Asp Leu Asp 
    1610                 1615                 1620             


Glu Gly  Val Gly Gly Lys Arg  Arg Ser Met Glu Val  Lys Pro Ala 
    1625                 1630                 1635             


Gln Ala  Ser His Thr Asn Tyr  Leu Leu Met Arg Gly  Tyr Tyr Ser 
    1640                 1645                 1650             


Pro Gly  Ile Val Ser Thr Arg  Asn Leu Asn Pro Asn  Asp Ser Ile 
    1655                 1660                 1665             


Val Val  Asn Ser Cys Gln Met  Lys Phe Gln Leu Arg  Cys Thr Pro 
    1670                 1675                 1680             


Val Pro  Ala Arg Leu Arg Pro  Ala Ala Ala Pro Leu  Glu Glu Leu 
    1685                 1690                 1695             


Thr Met  Gly Thr Ser Cys Leu  Pro Asp Thr Phe Thr  Lys Leu Ile 
    1700                 1705                 1710             


Asn Pro  Gln Glu Asn Thr Cys  Ser Leu Glu Glu Phe  Val Leu Gln 
    1715                 1720                 1725             


Leu Glu  Leu Ser Gly Tyr Ser  Pro Glu Asp Leu Thr  Ala Ala Leu 
    1730                 1735                 1740             


Glu Ile  Leu Glu Ala Ile Ile  Ala Thr Gly Cys Phe  Gly Ile Asp 
    1745                 1750                 1755             


Lys Glu  Glu Leu Arg Arg Arg  Phe Ser Ala Leu Glu  Lys Ala Gly 
    1760                 1765                 1770             


Gly Gly  Arg Thr Arg Thr Phe  Ala Asp Cys Ile Gln  Ala Leu Leu 
    1775                 1780                 1785             


Glu Gln  His Gln Val Leu Glu  Val Gly Gly Asn Thr  Ala Arg Leu 
    1790                 1795                 1800             


Val Ala  Met Gly Ser Ala Trp  Pro Trp Leu Leu His  Ser Val Arg 
    1805                 1810                 1815             


Leu Lys  Asp Arg Glu Asp Ala  Asp Ile Gln Arg Glu  Asp Pro Gln 
    1820                 1825                 1830             


Ala Arg  Pro Leu Glu Gly Ser  Ser Ser Glu Asp Ser  Pro Pro Glu 
    1835                 1840                 1845             


Gly Gln  Ala Pro Pro Ser His  Ser Pro Arg Gly Thr  Lys Arg Arg 
    1850                 1855                 1860             


Ala Ser  Trp Ala Ser Glu Asn  Gly Glu Thr Asp Ala  Glu Gly Thr 
    1865                 1870                 1875             


Gln Met  Thr Pro Ala Lys Arg  Pro Ala Leu Gln Asp  Ser Asn Leu 
    1880                 1885                 1890             


Ala Pro  Ser Leu Gly Pro Gly  Ala Glu Asp Gly Ala  Glu Ala Gln 
    1895                 1900                 1905             


Ala Pro  Ser Pro Pro Pro Ala  Leu Glu Asp Thr Ala  Ala Ala Gly 
    1910                 1915                 1920             


Ala Ala  Gln Glu Asp Gln Glu  Gly Val Gly Glu Phe  Ser Ser Pro 
    1925                 1930                 1935             


Gly Gln  Glu Gln Leu Ser Gly  Gln Ala Gln Pro Pro  Glu Gly Ser 
    1940                 1945                 1950             


Glu Asp  Pro Arg Gly Phe Thr  Glu Ser Phe Gly Ala  Ala Asn Ile 
    1955                 1960                 1965             


Ser Gln  Ala Ala Arg Glu Arg  Asp Cys Glu Ser Val  Cys Phe Ile 
    1970                 1975                 1980             


Gly Arg  Pro Trp Arg Val Val  Asp Gly His Leu Asn  Leu Pro Val 
    1985                 1990                 1995             


Cys Lys  Gly Met Met Glu Ala  Met Leu Tyr His Ile  Met Thr Arg 
    2000                 2005                 2010             


Pro Gly  Ile Pro Glu Ser Ser  Leu Leu Arg His Tyr  Gln Gly Val 
    2015                 2020                 2025             


Leu Gln  Pro Val Ala Val Leu  Glu Leu Leu Gln Gly  Leu Glu Ser 
    2030                 2035                 2040             


Leu Gly  Cys Ile Arg Lys Arg  Trp Leu Arg Lys Pro  Arg Pro Val 
    2045                 2050                 2055             


Ser Leu  Phe Ser Thr Pro Val  Val Glu Glu Val Glu  Val Pro Ser 
    2060                 2065                 2070             


Ser Leu  Asp Glu Ser Pro Met  Ala Phe Tyr Glu Pro  Thr Leu Asp 
    2075                 2080                 2085             


Cys Thr  Leu Arg Leu Gly Arg  Val Phe Pro His Glu  Val Asn Trp 
    2090                 2095                 2100             


Asn Lys  Trp Ile His Leu 
    2105                 


<210>  4804
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTPBP1__Homo_sapiens__NP_004277

<400>  4804

Met Ala Thr Glu Arg Ser Arg Ser Ala Met Asp Ser Pro Val Pro Ala 
1               5                   10                  15      


Ser Met Phe Ala Pro Glu Pro Ser Ser Pro Gly Ala Ala Arg Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Arg Leu His Gly Gly Phe Asp Ser Asp Cys Ser Glu 
        35                  40                  45              


Asp Gly Glu Ala Leu Asn Gly Glu Pro Glu Leu Asp Leu Thr Ser Lys 
    50                  55                  60                  


Leu Val Leu Val Ser Pro Thr Ser Glu Gln Tyr Asp Ser Leu Leu Arg 
65                  70                  75                  80  


Gln Met Trp Glu Arg Met Asp Glu Gly Cys Gly Glu Thr Ile Tyr Val 
                85                  90                  95      


Ile Gly Gln Gly Ser Asp Gly Thr Glu Tyr Gly Leu Ser Glu Ala Asp 
            100                 105                 110         


Met Glu Ala Ser Tyr Ala Thr Val Lys Ser Met Ala Glu Gln Ile Glu 
        115                 120                 125             


Ala Asp Val Ile Leu Leu Arg Glu Arg Gln Glu Ala Gly Gly Arg Val 
    130                 135                 140                 


Arg Asp Tyr Leu Val Arg Lys Arg Val Gly Asp Asn Asp Phe Leu Glu 
145                 150                 155                 160 


Val Arg Val Ala Val Val Gly Asn Val Asp Ala Gly Lys Ser Thr Leu 
                165                 170                 175     


Leu Gly Val Leu Thr His Gly Glu Leu Asp Asn Gly Arg Gly Phe Ala 
            180                 185                 190         


Arg Gln Lys Leu Phe Arg His Lys His Glu Ile Glu Ser Gly Arg Thr 
        195                 200                 205             


Ser Ser Val Gly Asn Asp Ile Leu Gly Phe Asp Ser Glu Gly Asn Val 
    210                 215                 220                 


Val Asn Lys Pro Asp Ser His Gly Gly Ser Leu Glu Trp Thr Lys Ile 
225                 230                 235                 240 


Cys Glu Lys Ser Thr Lys Val Ile Thr Phe Ile Asp Leu Ala Gly His 
                245                 250                 255     


Glu Lys Tyr Leu Lys Thr Thr Val Phe Gly Met Thr Gly His Leu Pro 
            260                 265                 270         


Asp Phe Cys Met Leu Met Val Gly Ser Asn Ala Gly Ile Val Gly Met 
        275                 280                 285             


Thr Lys Glu His Leu Gly Leu Ala Leu Ala Leu Asn Val Pro Val Phe 
    290                 295                 300                 


Val Val Val Thr Lys Ile Asp Met Cys Pro Ala Asn Ile Leu Gln Glu 
305                 310                 315                 320 


Thr Leu Lys Leu Leu Gln Arg Leu Leu Lys Ser Pro Gly Cys Arg Lys 
                325                 330                 335     


Ile Pro Val Leu Val Gln Ser Lys Asp Asp Val Ile Val Thr Ala Ser 
            340                 345                 350         


Asn Phe Ser Ser Glu Arg Met Cys Pro Ile Phe Gln Ile Ser Asn Val 
        355                 360                 365             


Thr Gly Glu Asn Leu Asp Leu Leu Lys Met Phe Leu Asn Leu Leu Ser 
    370                 375                 380                 


Pro Arg Thr Ser Tyr Arg Glu Glu Glu Pro Ala Glu Phe Gln Ile Asp 
385                 390                 395                 400 


Asp Thr Tyr Ser Val Pro Gly Val Gly Thr Val Val Ser Gly Thr Thr 
                405                 410                 415     


Leu Arg Gly Leu Ile Lys Leu Asn Asp Thr Leu Leu Leu Gly Pro Asp 
            420                 425                 430         


Pro Leu Gly Asn Phe Leu Ser Ile Ala Val Lys Ser Ile His Arg Lys 
        435                 440                 445             


Arg Met Pro Val Lys Glu Val Arg Gly Gly Gln Thr Ala Ser Phe Ala 
    450                 455                 460                 


Leu Lys Lys Ile Lys Arg Ser Ser Ile Arg Lys Gly Met Val Met Val 
465                 470                 475                 480 


Ser Pro Arg Leu Asn Pro Gln Ala Ser Trp Glu Phe Glu Ala Glu Ile 
                485                 490                 495     


Leu Val Leu His His Pro Thr Thr Ile Ser Pro Arg Tyr Gln Ala Met 
            500                 505                 510         


Val His Cys Gly Ser Ile Arg Gln Thr Ala Thr Ile Leu Ser Met Asp 
        515                 520                 525             


Lys Asp Cys Leu Arg Thr Gly Asp Lys Ala Thr Val His Phe Arg Phe 
    530                 535                 540                 


Ile Lys Thr Pro Glu Tyr Leu His Ile Asp Gln Arg Leu Val Phe Arg 
545                 550                 555                 560 


Glu Gly Arg Thr Lys Ala Val Gly Thr Ile Thr Lys Leu Leu Gln Thr 
                565                 570                 575     


Thr Asn Asn Ser Pro Met Asn Ser Lys Pro Gln Gln Ile Lys Met Gln 
            580                 585                 590         


Ser Thr Lys Lys Gly Pro Leu Thr Lys Arg Asp Glu Gly Gly Pro Ser 
        595                 600                 605             


Gly Gly Pro Ala Val Gly Ala Pro Pro Pro Gly Asp Glu Ala Ser Ser 
    610                 615                 620                 


Val Gly Ala Gly Gln Pro Ala Ala Ser Ser Asn Leu Gln Pro Gln Pro 
625                 630                 635                 640 


Lys Pro Ser Ser Gly Gly Arg Arg Arg Gly Gly Gln Arg His Lys Val 
                645                 650                 655     


Lys Ser Gln Gly Ala Cys Val Thr Pro Ala Ser Gly Cys 
            660                 665                 


<210>  4805
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTPBP3__Homo_sapiens__NP_001122327

<400>  4805

Met Trp Arg Gly Leu Trp Thr Leu Ala Ala Gln Ala Ala Arg Gly Pro 
1               5                   10                  15      


Arg Arg Leu Cys Thr Arg Arg Ser Ser Gly Ala Pro Ala Pro Gly Ser 
            20                  25                  30          


Gly Ala Thr Ile Phe Ala Leu Ser Ser Gly Gln Gly Arg Cys Gly Ile 
        35                  40                  45              


Ala Val Ile Arg Thr Ser Gly Pro Ala Ser Gly His Ala Leu Arg Ile 
    50                  55                  60                  


Leu Thr Ala Pro Arg Asp Leu Pro Leu Ala Arg His Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Leu Ser Asp Pro Arg Ser Gly Glu Pro Leu Asp Arg Ala Leu Val 
                85                  90                  95      


Leu Trp Phe Pro Gly Pro Gln Ser Phe Thr Gly Glu Asp Cys Val Glu 
            100                 105                 110         


Phe His Val His Gly Gly Pro Ala Val Val Ser Gly Val Leu Gln Ala 
        115                 120                 125             


Leu Gly Ser Val Pro Gly Leu Arg Pro Ala Glu Ala Gly Glu Phe Thr 
    130                 135                 140                 


Arg Arg Ala Phe Ala Asn Gly Lys Leu Asn Leu Thr Glu Val Glu Gly 
145                 150                 155                 160 


Leu Ala Asp Leu Ile His Ala Glu Thr Glu Ala Gln Arg Arg Gln Ala 
                165                 170                 175     


Leu Arg Gln Leu Asp Gly Glu Leu Gly His Leu Cys Arg Gly Trp Ala 
            180                 185                 190         


Glu Thr Leu Thr Lys Ala Leu Ala His Val Glu Ala Tyr Ile Asp Phe 
        195                 200                 205             


Gly Glu Asp Asp Asn Leu Glu Glu Gly Val Leu Glu Gln Ala Asp Ile 
    210                 215                 220                 


Glu Val Arg Ala Leu Gln Val Ala Leu Gly Ala His Leu Arg Asp Ala 
225                 230                 235                 240 


Arg Arg Gly Gln Arg Leu Arg Ser Gly Val His Val Val Val Thr Gly 
                245                 250                 255     


Pro Pro Asn Ala Gly Lys Ser Ser Leu Val Asn Leu Leu Ser Arg Lys 
            260                 265                 270         


Pro Val Ser Ile Val Ser Pro Glu Pro Gly Thr Thr Arg Asp Val Leu 
        275                 280                 285             


Glu Thr Pro Val Asp Leu Ala Gly Phe Pro Val Leu Leu Ser Asp Thr 
    290                 295                 300                 


Ala Gly Leu Arg Glu Gly Val Gly Pro Val Glu Gln Glu Gly Val Arg 
305                 310                 315                 320 


Arg Ala Arg Glu Ser Cys Asn Phe Leu Ala Thr Val Val Ala Ser Val 
                325                 330                 335     


Gly Ala Gln Ser Pro Ser Asp Ser Ser Gln Arg Leu Leu Leu Val Leu 
            340                 345                 350         


Asn Lys Ser Asp Leu Leu Ser Pro Glu Gly Pro Gly Pro Gly Pro Asp 
        355                 360                 365             


Leu Pro Pro His Leu Leu Leu Ser Cys Leu Thr Gly Glu Gly Leu Asp 
    370                 375                 380                 


Gly Leu Leu Glu Ala Leu Arg Lys Glu Leu Ala Ala Val Cys Gly Asp 
385                 390                 395                 400 


Pro Ser Thr Asp Pro Pro Leu Leu Thr Arg Ala Arg His Gln His His 
                405                 410                 415     


Leu Gln Gly Cys Leu Asp Ala Leu Gly His Tyr Lys Gln Ser Lys Asp 
            420                 425                 430         


Leu Ala Leu Ala Ala Glu Ala Leu Arg Val Ala Arg Gly His Leu Thr 
        435                 440                 445             


Arg Leu Thr Gly Gly Gly Gly Thr Glu Glu Ile Leu Asp Ile Ile Phe 
    450                 455                 460                 


Gln Asp Phe Cys Val Gly Lys 
465                 470     


<210>  4806
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTPBP4__Homo_sapiens__NP_036473

<400>  4806

Met Ala His Tyr Asn Phe Lys Lys Ile Thr Val Val Pro Ser Ala Lys 
1               5                   10                  15      


Asp Phe Ile Asp Leu Thr Leu Ser Lys Thr Gln Arg Lys Thr Pro Thr 
            20                  25                  30          


Val Ile His Lys His Tyr Gln Ile His Arg Ile Arg His Phe Tyr Met 
        35                  40                  45              


Arg Lys Val Lys Phe Thr Gln Gln Asn Tyr His Asp Arg Leu Ser Gln 
    50                  55                  60                  


Ile Leu Thr Asp Phe Pro Lys Leu Asp Asp Ile His Pro Phe Tyr Ala 
65                  70                  75                  80  


Asp Leu Met Asn Ile Leu Tyr Asp Lys Asp His Tyr Lys Leu Ala Leu 
                85                  90                  95      


Gly Gln Ile Asn Ile Ala Lys Asn Leu Val Asp Asn Val Ala Lys Asp 
            100                 105                 110         


Tyr Val Arg Leu Met Lys Tyr Gly Asp Ser Leu Tyr Arg Cys Lys Gln 
        115                 120                 125             


Leu Lys Arg Ala Ala Leu Gly Arg Met Cys Thr Val Ile Lys Arg Gln 
    130                 135                 140                 


Lys Gln Ser Leu Glu Tyr Leu Glu Gln Val Arg Gln His Leu Ser Arg 
145                 150                 155                 160 


Leu Pro Thr Ile Asp Pro Asn Thr Arg Thr Leu Leu Leu Cys Gly Tyr 
                165                 170                 175     


Pro Asn Val Gly Lys Ser Ser Phe Ile Asn Lys Val Thr Arg Ala Asp 
            180                 185                 190         


Val Asp Val Gln Pro Tyr Ala Phe Thr Thr Lys Ser Leu Phe Val Gly 
        195                 200                 205             


His Met Asp Tyr Lys Tyr Leu Arg Trp Gln Val Val Asp Thr Pro Gly 
    210                 215                 220                 


Ile Leu Asp His Pro Leu Glu Asp Arg Asn Thr Ile Glu Met Gln Ala 
225                 230                 235                 240 


Ile Thr Ala Leu Ala His Leu Arg Ala Ala Val Leu Tyr Val Met Asp 
                245                 250                 255     


Leu Ser Glu Gln Cys Gly His Gly Leu Arg Glu Gln Leu Glu Leu Phe 
            260                 265                 270         


Gln Asn Ile Arg Pro Leu Phe Ile Asn Lys Pro Leu Ile Val Val Ala 
        275                 280                 285             


Asn Lys Cys Asp Val Lys Arg Ile Ala Glu Leu Ser Glu Asp Asp Gln 
    290                 295                 300                 


Lys Ile Phe Thr Asp Leu Gln Ser Glu Gly Phe Pro Val Ile Glu Thr 
305                 310                 315                 320 


Ser Thr Leu Thr Glu Glu Gly Val Ile Lys Val Lys Thr Glu Ala Cys 
                325                 330                 335     


Asp Arg Leu Leu Ala His Arg Val Glu Thr Lys Met Lys Gly Asn Lys 
            340                 345                 350         


Val Asn Glu Val Leu Asn Arg Leu His Leu Ala Ile Pro Thr Arg Arg 
        355                 360                 365             


Asp Asp Lys Glu Arg Pro Pro Phe Ile Pro Glu Gly Val Val Ala Arg 
    370                 375                 380                 


Arg Lys Arg Met Glu Thr Glu Glu Ser Arg Lys Lys Arg Glu Arg Asp 
385                 390                 395                 400 


Leu Glu Leu Glu Met Gly Asp Asp Tyr Ile Leu Asp Leu Gln Lys Tyr 
                405                 410                 415     


Trp Asp Leu Met Asn Leu Ser Glu Lys His Asp Lys Ile Pro Glu Ile 
            420                 425                 430         


Trp Glu Gly His Asn Ile Ala Asp Tyr Ile Asp Pro Ala Ile Met Lys 
        435                 440                 445             


Lys Leu Glu Glu Leu Glu Lys Glu Glu Glu Leu Arg Thr Ala Ala Gly 
    450                 455                 460                 


Glu Tyr Asp Ser Val Ser Glu Ser Glu Asp Glu Glu Met Leu Glu Ile 
465                 470                 475                 480 


Arg Gln Leu Ala Lys Gln Ile Arg Glu Lys Lys Lys Leu Lys Ile Leu 
                485                 490                 495     


Glu Ser Lys Glu Lys Asn Thr Gln Gly Pro Arg Met Pro Arg Thr Ala 
            500                 505                 510         


Lys Lys Val Gln Arg Thr Val Leu Glu Lys Glu Met Arg Ser Leu Gly 
        515                 520                 525             


Val Asp Met Asp Asp Lys Asp Asp Ala His Tyr Ala Val Gln Ala Arg 
    530                 535                 540                 


Arg Ser Arg Ser Ile Thr Arg Lys Arg Lys Arg Glu Asp Ser Ala Pro 
545                 550                 555                 560 


Pro Ser Ser Val Ala Arg Ser Gly Ser Cys Ser Arg Thr Pro Arg Asp 
                565                 570                 575     


Val Ser Gly Leu Arg Asp Val Lys Met Val Lys Lys Ala Lys Thr Met 
            580                 585                 590         


Met Lys Asn Ala Gln Lys Lys Met Asn Arg Leu Gly Lys Lys Gly Glu 
        595                 600                 605             


Ala Asp Arg His Val Phe Asp Met Lys Pro Lys His Leu Leu Ser Gly 
    610                 615                 620                 


Lys Arg Lys Ala Gly Lys Lys Asp Arg Arg 
625                 630                 


<210>  4807
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTSF1__Homo_sapiens__NP_653195

<400>  4807

Met Glu Glu Thr Tyr Thr Asp Ser Leu Asp Pro Glu Lys Leu Leu Gln 
1               5                   10                  15      


Cys Pro Tyr Asp Lys Asn His Gln Ile Arg Ala Cys Arg Phe Pro Tyr 
            20                  25                  30          


His Leu Ile Lys Cys Arg Lys Asn His Pro Asp Val Ala Ser Lys Leu 
        35                  40                  45              


Ala Thr Cys Pro Phe Asn Ala Arg His Gln Val Pro Arg Ala Glu Ile 
    50                  55                  60                  


Ser His His Ile Ser Ser Cys Asp Asp Arg Ser Cys Ile Glu Gln Asp 
65                  70                  75                  80  


Val Val Asn Gln Thr Arg Ser Leu Arg Gln Glu Thr Leu Ala Glu Ser 
                85                  90                  95      


Thr Trp Gln Cys Pro Pro Cys Asp Glu Asp Trp Asp Lys Asp Leu Trp 
            100                 105                 110         


Glu Gln Thr Ser Thr Pro Phe Val Trp Gly Thr Thr His Tyr Ser Asp 
        115                 120                 125             


Asn Asn Ser Pro Ala Ser Asn Ile Val Thr Glu His Lys Asn Asn Leu 
    130                 135                 140                 


Ala Ser Gly Met Arg Val Pro Lys Ser Leu Pro Tyr Val Leu Pro Trp 
145                 150                 155                 160 


Lys Asn Asn Gly Asn Ala Gln 
                165         


<210>  4808
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCA1A__Homo_sapiens__NP_000400

<400>  4808

Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 
1               5                   10                  15      


Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser Gly 
            20                  25                  30          


Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu Lys Asn Leu 
        35                  40                  45              


Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met Phe Glu Thr Phe Asp 
    50                  55                  60                  


Phe Asn Lys Asp Gly Tyr Ile Asp Phe Met Glu Tyr Val Ala Ala Leu 
65                  70                  75                  80  


Ser Leu Val Leu Lys Gly Lys Val Glu Gln Lys Leu Arg Trp Tyr Phe 
                85                  90                  95      


Lys Leu Tyr Asp Val Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 
            100                 105                 110         


Leu Thr Ile Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 
        115                 120                 125             


Thr Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 
    130                 135                 140                 


Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val 
145                 150                 155                 160 


Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser Leu Asp Leu 
                165                 170                 175     


Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu Gln Asp Glu Glu Gly 
            180                 185                 190         


Ala Asp Glu Ala Ala Glu Ala Ala Gly 
        195                 200     


<210>  4809
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCA1B__Homo_sapiens__NP_002089

<400>  4809

Met Gly Gln Glu Phe Ser Trp Glu Glu Ala Glu Ala Ala Gly Glu Ile 
1               5                   10                  15      


Asp Val Ala Glu Leu Gln Glu Trp Tyr Lys Lys Phe Val Met Glu Cys 
            20                  25                  30          


Pro Ser Gly Thr Leu Phe Met His Glu Phe Lys Arg Phe Phe Lys Val 
        35                  40                  45              


Thr Asp Asp Glu Glu Ala Ser Gln Tyr Val Glu Gly Met Phe Arg Ala 
    50                  55                  60                  


Phe Asp Lys Asn Gly Asp Asn Thr Ile Asp Phe Leu Glu Tyr Val Ala 
65                  70                  75                  80  


Ala Leu Asn Leu Val Leu Arg Gly Thr Leu Glu His Lys Leu Lys Trp 
                85                  90                  95      


Thr Phe Lys Ile Tyr Asp Lys Asp Gly Asn Gly Cys Ile Asp Arg Leu 
            100                 105                 110         


Glu Leu Leu Asn Ile Val Glu Gly Ile Tyr Gln Leu Lys Lys Ala Cys 
        115                 120                 125             


Arg Arg Glu Leu Gln Thr Glu Gln Gly Gln Leu Leu Thr Pro Glu Glu 
    130                 135                 140                 


Val Val Asp Arg Ile Phe Leu Leu Val Asp Glu Asn Gly Asp Gly Gln 
145                 150                 155                 160 


Leu Ser Leu Asn Glu Phe Val Glu Gly Ala Arg Arg Asp Lys Trp Val 
                165                 170                 175     


Met Lys Met Leu Gln Met Asp Met Asn Pro Ser Ser Trp Leu Ala Gln 
            180                 185                 190         


Gln Arg Arg Lys Ser Ala Met Phe 
        195                 200 


<210>  4810
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCD1__Homo_sapiens__NP_001271183

<400>  4810

Met Arg Thr Glu Ala Glu Ala Ala Gly Pro Pro Leu Glu Pro Gly Asp 
1               5                   10                  15      


Phe Val Gln Leu Pro Val Pro Val Ile Gln Gln Leu Tyr His Trp Asp 
            20                  25                  30          


Cys Gly Leu Ala Cys Ser Arg Met Val Leu Arg Tyr Leu Gly Gln Leu 
        35                  40                  45              


Asp Asp Ser Glu Phe Glu Arg Ala Leu Gln Lys Leu Gln Leu Thr Arg 
    50                  55                  60                  


Ser Ile Trp Thr Ile Asp Leu Ala Tyr Leu Met His His Phe Gly Val 
65                  70                  75                  80  


Arg His Arg Phe Cys Thr Gln Thr Leu Gly Val Asp Lys Gly Tyr Lys 
                85                  90                  95      


Asn Gln Ser Phe Tyr Arg Lys His Phe Asp Thr Glu Glu Thr Arg Val 
            100                 105                 110         


Asn Gln Leu Phe Ala Gln Ala Lys Ala Cys Lys Val Leu Val Glu Lys 
        115                 120                 125             


Cys Thr Val Ser Val Lys Asp Ile Gln Ala His Leu Ala Gln Gly His 
    130                 135                 140                 


Val Ala Ile Val Leu Val Asn Ser Gly Val Leu His Cys Asp Leu Cys 
145                 150                 155                 160 


Ser Ser Pro Val Lys Tyr Cys Cys Phe Thr Pro Ser Gly His His Cys 
                165                 170                 175     


Phe Cys Arg Thr Pro Asp Tyr Gln Gly His Phe Ile Val Leu Arg Gly 
            180                 185                 190         


Tyr Asn Arg Ala Thr Gly Cys Ile Phe Tyr Asn Asn Pro Ala Tyr Ala 
        195                 200                 205             


Asp Arg Met Cys Ser Thr Ser Ile Ser Asn Phe Glu Glu Ala Arg Thr 
    210                 215                 220                 


Ser Tyr Gly Thr Asp Glu Asp Ile Leu Phe Val Tyr Leu Asp Ser 
225                 230                 235                 


<210>  4811
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCY1A2__Homo_sapiens__NP_000846

<400>  4811

Met Ser Arg Arg Lys Ile Ser Ser Glu Ser Phe Ser Ser Leu Gly Ser 
1               5                   10                  15      


Asp Tyr Leu Glu Thr Ser Pro Glu Glu Glu Gly Glu Cys Pro Leu Ser 
            20                  25                  30          


Arg Leu Cys Trp Asn Gly Ser Arg Ser Pro Pro Gly Pro Leu Glu Pro 
        35                  40                  45              


Ser Pro Ala Ala Ala Ala Ala Ala Ala Ala Pro Ala Pro Thr Pro Ala 
    50                  55                  60                  


Ala Ser Ala Ala Ala Ala Ala Ala Thr Ala Gly Ala Arg Arg Val Gln 
65                  70                  75                  80  


Arg Arg Arg Arg Val Asn Leu Asp Ser Leu Gly Glu Ser Ile Ser Arg 
                85                  90                  95      


Leu Thr Ala Pro Ser Pro Gln Thr Ile Gln Gln Thr Leu Lys Arg Thr 
            100                 105                 110         


Leu Gln Tyr Tyr Glu His Gln Val Ile Gly Tyr Arg Asp Ala Glu Lys 
        115                 120                 125             


Asn Phe His Asn Ile Ser Asn Arg Cys Ser Tyr Ala Asp His Ser Asn 
    130                 135                 140                 


Lys Glu Glu Ile Glu Asp Val Ser Gly Ile Leu Gln Cys Thr Ala Asn 
145                 150                 155                 160 


Ile Leu Gly Leu Lys Phe Glu Glu Ile Gln Lys Arg Phe Gly Glu Glu 
                165                 170                 175     


Phe Phe Asn Ile Cys Phe His Glu Asn Glu Arg Val Leu Arg Ala Val 
            180                 185                 190         


Gly Gly Thr Leu Gln Asp Phe Phe Asn Gly Phe Asp Ala Leu Leu Glu 
        195                 200                 205             


His Ile Arg Thr Ser Phe Gly Lys Gln Ala Thr Leu Glu Ser Pro Ser 
    210                 215                 220                 


Phe Leu Cys Lys Glu Leu Pro Glu Gly Thr Leu Met Leu His Tyr Phe 
225                 230                 235                 240 


His Pro His His Ile Val Gly Phe Ala Met Leu Gly Met Ile Lys Ala 
                245                 250                 255     


Ala Gly Lys Lys Ile Tyr Arg Leu Asp Val Glu Val Glu Gln Val Ala 
            260                 265                 270         


Asn Glu Lys Leu Cys Ser Asp Val Ser Asn Pro Gly Asn Cys Ser Cys 
        275                 280                 285             


Leu Thr Phe Leu Ile Lys Glu Cys Glu Asn Thr Asn Ile Met Lys Asn 
    290                 295                 300                 


Leu Pro Gln Gly Thr Ser Gln Val Pro Ala Asp Leu Arg Ile Ser Ile 
305                 310                 315                 320 


Asn Thr Phe Cys Arg Ala Phe Pro Phe His Leu Met Phe Asp Pro Ser 
                325                 330                 335     


Met Ser Val Leu Gln Leu Gly Glu Gly Leu Arg Lys Gln Leu Arg Cys 
            340                 345                 350         


Asp Thr His Lys Val Leu Lys Phe Glu Asp Cys Phe Glu Ile Val Ser 
        355                 360                 365             


Pro Lys Val Asn Ala Thr Phe Glu Arg Val Leu Leu Arg Leu Ser Thr 
    370                 375                 380                 


Pro Phe Val Ile Arg Thr Lys Pro Glu Ala Ser Gly Ser Glu Asn Lys 
385                 390                 395                 400 


Asp Lys Val Met Glu Val Lys Gly Gln Met Ile His Val Pro Glu Ser 
                405                 410                 415     


Asn Ser Ile Leu Phe Leu Gly Ser Pro Cys Val Asp Lys Leu Asp Glu 
            420                 425                 430         


Leu Met Gly Arg Gly Leu His Leu Ser Asp Ile Pro Ile His Asp Ala 
        435                 440                 445             


Thr Arg Asp Val Ile Leu Val Gly Glu Gln Ala Lys Ala Gln Asp Gly 
    450                 455                 460                 


Leu Lys Lys Arg Met Asp Lys Leu Lys Ala Thr Leu Glu Arg Thr His 
465                 470                 475                 480 


Gln Ala Leu Glu Glu Glu Lys Lys Lys Thr Val Asp Leu Leu Tyr Ser 
                485                 490                 495     


Ile Phe Pro Gly Asp Val Ala Gln Gln Leu Trp Gln Gly Gln Gln Val 
            500                 505                 510         


Gln Ala Arg Lys Phe Asp Asp Val Thr Met Leu Phe Ser Asp Ile Val 
        515                 520                 525             


Gly Phe Thr Ala Ile Cys Ala Gln Cys Thr Pro Met Gln Val Ile Ser 
    530                 535                 540                 


Met Leu Asn Glu Leu Tyr Thr Arg Phe Asp His Gln Cys Gly Phe Leu 
545                 550                 555                 560 


Asp Ile Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Cys Val Ala Ala 
                565                 570                 575     


Gly Leu His Arg Lys Ser Leu Cys His Ala Lys Pro Ile Ala Leu Met 
            580                 585                 590         


Ala Leu Lys Met Met Glu Leu Ser Glu Glu Val Leu Thr Pro Asp Gly 
        595                 600                 605             


Arg Pro Ile Gln Met Arg Ile Gly Ile His Ser Gly Ser Val Leu Ala 
    610                 615                 620                 


Gly Val Val Gly Val Arg Met Pro Arg Tyr Cys Leu Phe Gly Asn Asn 
625                 630                 635                 640 


Val Thr Leu Ala Ser Lys Phe Glu Ser Gly Ser His Pro Arg Arg Ile 
                645                 650                 655     


Asn Val Ser Pro Thr Thr Tyr Gln Leu Leu Lys Arg Glu Glu Ser Phe 
            660                 665                 670         


Thr Phe Ile Pro Arg Ser Arg Glu Glu Leu Pro Asp Asn Phe Pro Lys 
        675                 680                 685             


Glu Ile Pro Gly Ile Cys Tyr Phe Leu Glu Val Arg Thr Gly Pro Lys 
    690                 695                 700                 


Pro Pro Lys Pro Ser Leu Ser Ser Ser Arg Ile Lys Lys Val Ser Tyr 
705                 710                 715                 720 


Asn Ile Gly Thr Met Phe Leu Arg Glu Thr Ser Leu 
                725                 730         


<210>  4812
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCY1A3__Homo_sapiens__NP_001124157

<400>  4812

Met Pro Pro Cys Phe His Asn Asp Cys Ser Glu Phe Val Asn Gln Pro 
1               5                   10                  15      


Tyr Leu Leu Tyr Ser Val His Met Lys Ser Thr Lys Pro Ser Leu Ser 
            20                  25                  30          


Pro Ser Lys Pro Gln Ser Ser Leu Val Ile Pro Thr Ser Leu Phe Cys 
        35                  40                  45              


Lys Thr Phe Pro Phe His Phe Met Phe Asp Lys Asp Met Thr Ile Leu 
    50                  55                  60                  


Gln Phe Gly Asn Gly Ile Arg Arg Leu Met Asn Arg Arg Asp Phe Gln 
65                  70                  75                  80  


Gly Lys Pro Asn Phe Glu Glu Tyr Phe Glu Ile Leu Thr Pro Lys Ile 
                85                  90                  95      


Asn Gln Thr Phe Ser Gly Ile Met Thr Met Leu Asn Met Gln Phe Val 
            100                 105                 110         


Val Arg Val Arg Arg Trp Asp Asn Ser Val Lys Lys Ser Ser Arg Val 
        115                 120                 125             


Met Asp Leu Lys Gly Gln Met Ile Tyr Ile Val Glu Ser Ser Ala Ile 
    130                 135                 140                 


Leu Phe Leu Gly Ser Pro Cys Val Asp Arg Leu Glu Asp Phe Thr Gly 
145                 150                 155                 160 


Arg Gly Leu Tyr Leu Ser Asp Ile Pro Ile His Asn Ala Leu Arg Asp 
                165                 170                 175     


Val Val Leu Ile Gly Glu Gln Ala Arg Ala Gln Asp Gly Leu Lys Lys 
            180                 185                 190         


Arg Leu Gly Lys Leu Lys Ala Thr Leu Glu Gln Ala His Gln Ala Leu 
        195                 200                 205             


Glu Glu Glu Lys Lys Lys Thr Val Asp Leu Leu Cys Ser Ile Phe Pro 
    210                 215                 220                 


Cys Glu Val Ala Gln Gln Leu Trp Gln Gly Gln Val Val Gln Ala Lys 
225                 230                 235                 240 


Lys Phe Ser Asn Val Thr Met Leu Phe Ser Asp Ile Val Gly Phe Thr 
                245                 250                 255     


Ala Ile Cys Ser Gln Cys Ser Pro Leu Gln Val Ile Thr Met Leu Asn 
            260                 265                 270         


Ala Leu Tyr Thr Arg Phe Asp Gln Gln Cys Gly Glu Leu Asp Val Tyr 
        275                 280                 285             


Lys Val Glu Thr Ile Gly Asp Ala Tyr Cys Val Ala Gly Gly Leu His 
    290                 295                 300                 


Lys Glu Ser Asp Thr His Ala Val Gln Ile Ala Leu Met Ala Leu Lys 
305                 310                 315                 320 


Met Met Glu Leu Ser Asp Glu Val Met Ser Pro His Gly Glu Pro Ile 
                325                 330                 335     


Lys Met Arg Ile Gly Leu His Ser Gly Ser Val Phe Ala Gly Val Val 
            340                 345                 350         


Gly Val Lys Met Pro Arg Tyr Cys Leu Phe Gly Asn Asn Val Thr Leu 
        355                 360                 365             


Ala Asn Lys Phe Glu Ser Cys Ser Val Pro Arg Lys Ile Asn Val Ser 
    370                 375                 380                 


Pro Thr Thr Tyr Arg Leu Leu Lys Asp Cys Pro Gly Phe Val Phe Thr 
385                 390                 395                 400 


Pro Arg Ser Arg Glu Glu Leu Pro Pro Asn Phe Pro Ser Glu Ile Pro 
                405                 410                 415     


Gly Ile Cys His Phe Leu Asp Ala Tyr Gln Gln Gly Thr Asn Ser Lys 
            420                 425                 430         


Pro Cys Phe Gln Lys Lys Asp Val Glu Asp Gly Asn Ala Asn Phe Leu 
        435                 440                 445             


Gly Lys Ala Ser Gly Ile Asp 
    450                 455 


<210>  4813
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCY1B3__Homo_sapiens__NP_000848

<400>  4813

Met Tyr Gly Phe Val Asn His Ala Leu Glu Leu Leu Val Ile Arg Asn 
1               5                   10                  15      


Tyr Gly Pro Glu Val Trp Glu Asp Ile Lys Lys Glu Ala Gln Leu Asp 
            20                  25                  30          


Glu Glu Gly Gln Phe Leu Val Arg Ile Ile Tyr Asp Asp Ser Lys Thr 
        35                  40                  45              


Tyr Asp Leu Val Ala Ala Ala Ser Lys Val Leu Asn Leu Asn Ala Gly 
    50                  55                  60                  


Glu Ile Leu Gln Met Phe Gly Lys Met Phe Phe Val Phe Cys Gln Glu 
65                  70                  75                  80  


Ser Gly Tyr Asp Thr Ile Leu Arg Val Leu Gly Ser Asn Val Arg Glu 
                85                  90                  95      


Phe Leu Gln Asn Leu Asp Ala Leu His Asp His Leu Ala Thr Ile Tyr 
            100                 105                 110         


Pro Gly Met Arg Ala Pro Ser Phe Arg Cys Thr Asp Ala Glu Lys Gly 
        115                 120                 125             


Lys Gly Leu Ile Leu His Tyr Tyr Ser Glu Arg Glu Gly Leu Gln Asp 
    130                 135                 140                 


Ile Val Ile Gly Ile Ile Lys Thr Val Ala Gln Gln Ile His Gly Thr 
145                 150                 155                 160 


Glu Ile Asp Met Lys Val Ile Gln Gln Arg Asn Glu Glu Cys Asp His 
                165                 170                 175     


Thr Gln Phe Leu Ile Glu Glu Lys Glu Ser Lys Glu Glu Asp Phe Tyr 
            180                 185                 190         


Glu Asp Leu Asp Arg Phe Glu Glu Asn Gly Thr Gln Glu Ser Arg Ile 
        195                 200                 205             


Ser Pro Tyr Thr Phe Cys Lys Ala Phe Pro Phe His Ile Ile Phe Asp 
    210                 215                 220                 


Arg Asp Leu Val Val Thr Gln Cys Gly Asn Ala Ile Tyr Arg Val Leu 
225                 230                 235                 240 


Pro Gln Leu Gln Pro Gly Asn Cys Ser Leu Leu Ser Val Phe Ser Leu 
                245                 250                 255     


Val Arg Pro His Ile Asp Ile Ser Phe His Gly Ile Leu Ser His Ile 
            260                 265                 270         


Asn Thr Val Phe Val Leu Arg Ser Lys Glu Gly Leu Leu Asp Val Glu 
        275                 280                 285             


Lys Leu Glu Cys Glu Asp Glu Leu Thr Gly Thr Glu Ile Ser Cys Leu 
    290                 295                 300                 


Arg Leu Lys Gly Gln Met Ile Tyr Leu Pro Glu Ala Asp Ser Ile Leu 
305                 310                 315                 320 


Phe Leu Cys Ser Pro Ser Val Met Asn Leu Asp Asp Leu Thr Arg Arg 
                325                 330                 335     


Gly Leu Tyr Leu Ser Asp Ile Pro Leu His Asp Ala Thr Arg Asp Leu 
            340                 345                 350         


Val Leu Leu Gly Glu Gln Phe Arg Glu Glu Tyr Lys Leu Thr Gln Glu 
        355                 360                 365             


Leu Glu Ile Leu Thr Asp Arg Leu Gln Leu Thr Leu Arg Ala Leu Glu 
    370                 375                 380                 


Asp Glu Lys Lys Lys Thr Asp Thr Leu Leu Tyr Ser Val Leu Pro Pro 
385                 390                 395                 400 


Ser Val Ala Asn Glu Leu Arg His Lys Arg Pro Val Pro Ala Lys Arg 
                405                 410                 415     


Tyr Asp Asn Val Thr Ile Leu Phe Ser Gly Ile Val Gly Phe Asn Ala 
            420                 425                 430         


Phe Cys Ser Lys His Ala Ser Gly Glu Gly Ala Met Lys Ile Val Asn 
        435                 440                 445             


Leu Leu Asn Asp Leu Tyr Thr Arg Phe Asp Thr Leu Thr Asp Ser Arg 
    450                 455                 460                 


Lys Asn Pro Phe Val Tyr Lys Val Glu Thr Val Gly Asp Lys Tyr Met 
465                 470                 475                 480 


Thr Val Ser Gly Leu Pro Glu Pro Cys Ile His His Ala Arg Ser Ile 
                485                 490                 495     


Cys His Leu Ala Leu Asp Met Met Glu Ile Ala Gly Gln Val Gln Val 
            500                 505                 510         


Asp Gly Glu Ser Val Gln Ile Thr Ile Gly Ile His Thr Gly Glu Val 
        515                 520                 525             


Val Thr Gly Val Ile Gly Gln Arg Met Pro Arg Tyr Cys Leu Phe Gly 
    530                 535                 540                 


Asn Thr Val Asn Leu Thr Ser Arg Thr Glu Thr Thr Gly Glu Lys Gly 
545                 550                 555                 560 


Lys Ile Asn Val Ser Glu Tyr Thr Tyr Arg Cys Leu Met Ser Pro Glu 
                565                 570                 575     


Asn Ser Asp Pro Gln Phe His Leu Glu His Arg Gly Pro Val Ser Met 
            580                 585                 590         


Lys Gly Lys Lys Glu Pro Met Gln Val Trp Phe Leu Ser Arg Lys Asn 
        595                 600                 605             


Thr Gly Thr Glu Glu Thr Lys Gln Asp Asp Asp 
    610                 615                 


<210>  4814
<211>  1073
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCY2C__Homo_sapiens__NP_004954

<400>  4814

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu 
            420                 425                 430         


Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu 
        435                 440                 445             


Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg 
    450                 455                 460                 


Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu 
465                 470                 475                 480 


Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg 
                485                 490                 495     


Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg 
            500                 505                 510         


Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys 
        515                 520                 525             


Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu 
    530                 535                 540                 


Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val 
545                 550                 555                 560 


Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr 
                565                 570                 575     


Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser 
            580                 585                 590         


Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys 
        595                 600                 605             


Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser 
    610                 615                 620                 


Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro 
625                 630                 635                 640 


Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn 
                645                 650                 655     


Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu 
            660                 665                 670         


Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg 
        675                 680                 685             


Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe 
    690                 695                 700                 


Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val 
705                 710                 715                 720 


Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro 
                725                 730                 735     


Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe 
            740                 745                 750         


His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu 
        755                 760                 765             


Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln 
    770                 775                 780                 


Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu 
785                 790                 795                 800 


Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu 
                805                 810                 815     


Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
            820                 825                 830         


Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met 
        835                 840                 845             


Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp 
    850                 855                 860                 


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly 
865                 870                 875                 880 


Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met 
                885                 890                 895     


Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu 
            900                 905                 910         


Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys 
        915                 920                 925             


Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly 
    930                 935                 940                 


Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu 
945                 950                 955                 960 


Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu 
                965                 970                 975     


Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg 
            980                 985                 990         


Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe 
        995                 1000                 1005             


Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln 
    1010                 1015                 1020             


Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln 
    1025                 1030                 1035             


Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr 
    1040                 1045                 1050             


Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys 
    1055                 1060                 1065             


Glu Ser  Thr Tyr Phe 
    1070             


<210>  4815
<211>  1103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCY2D__Homo_sapiens__NP_000171

<400>  4815

Met Thr Ala Cys Ala Arg Arg Ala Gly Gly Leu Pro Asp Pro Gly Leu 
1               5                   10                  15      


Cys Gly Pro Ala Trp Trp Ala Pro Ser Leu Pro Arg Leu Pro Arg Ala 
            20                  25                  30          


Leu Pro Arg Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Pro 
        35                  40                  45              


Ala Leu Ser Ala Val Phe Thr Val Gly Val Leu Gly Pro Trp Ala Cys 
    50                  55                  60                  


Asp Pro Ile Phe Ser Arg Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Ala Arg Leu Asn Arg Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe 
                85                  90                  95      


Glu Val Ala Leu Leu Pro Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly 
            100                 105                 110         


Ala Val Ser Ser Ala Leu Ala Arg Val Ser Gly Leu Val Gly Pro Val 
        115                 120                 125             


Asn Pro Ala Ala Cys Arg Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly 
    130                 135                 140                 


Ile Ala Leu Val Pro Trp Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr 
145                 150                 155                 160 


Thr Ala Pro Ala Val Thr Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu 
                165                 170                 175     


Arg Ala Phe Gly Trp Ala Arg Val Ala Leu Val Thr Ala Pro Gln Asp 
            180                 185                 190         


Leu Trp Val Glu Ala Gly Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg 
        195                 200                 205             


Gly Leu Pro Val Ala Ser Val Thr Ser Met Glu Pro Leu Asp Leu Ser 
    210                 215                 220                 


Gly Ala Arg Glu Ala Leu Arg Lys Val Arg Asp Gly Pro Arg Val Thr 
225                 230                 235                 240 


Ala Val Ile Met Val Met His Ser Val Leu Leu Gly Gly Glu Glu Gln 
                245                 250                 255     


Arg Tyr Leu Leu Glu Ala Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser 
            260                 265                 270         


Leu Val Phe Leu Pro Phe Asp Thr Ile His Tyr Ala Leu Ser Pro Gly 
        275                 280                 285             


Pro Glu Ala Leu Ala Ala Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala 
    290                 295                 300                 


His Asp Ala Val Leu Thr Leu Thr Arg His Cys Pro Ser Glu Gly Ser 
305                 310                 315                 320 


Val Leu Asp Ser Leu Arg Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser 
                325                 330                 335     


Asp Leu Asn Leu Gln Gln Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp 
            340                 345                 350         


Ala Val Phe Leu Leu Ala Arg Gly Val Ala Glu Ala Arg Ala Ala Ala 
        355                 360                 365             


Gly Gly Arg Trp Val Ser Gly Ala Ala Val Ala Arg His Ile Arg Asp 
    370                 375                 380                 


Ala Gln Val Pro Gly Phe Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro 
385                 390                 395                 400 


Pro Phe Val Leu Leu Asp Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala 
                405                 410                 415     


Thr Tyr Met Leu Asp Pro Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr 
            420                 425                 430         


Arg Met His Phe Pro Arg Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser 
        435                 440                 445             


Cys Trp Phe Asp Pro Asn Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly 
    450                 455                 460                 


Leu Val Phe Leu Gly Phe Leu Leu Val Val Gly Met Gly Leu Ala Gly 
465                 470                 475                 480 


Ala Phe Leu Ala His Tyr Val Arg His Arg Leu Leu His Met Gln Met 
                485                 490                 495     


Val Ser Gly Pro Asn Lys Ile Ile Leu Thr Val Asp Asp Ile Thr Phe 
            500                 505                 510         


Leu His Pro His Gly Gly Thr Ser Arg Lys Val Ala Gln Gly Ser Arg 
        515                 520                 525             


Ser Ser Leu Gly Ala Arg Ser Met Ser Asp Ile Arg Ser Gly Pro Ser 
    530                 535                 540                 


Gln His Leu Asp Ser Pro Asn Ile Gly Val Tyr Glu Gly Asp Arg Val 
545                 550                 555                 560 


Trp Leu Lys Lys Phe Pro Gly Asp Gln His Ile Ala Ile Arg Pro Ala 
                565                 570                 575     


Thr Lys Thr Ala Phe Ser Lys Leu Gln Glu Leu Arg His Glu Asn Val 
            580                 585                 590         


Ala Leu Tyr Leu Gly Leu Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala 
        595                 600                 605             


Ala Leu Trp Glu Gly Asn Leu Ala Val Val Ser Glu His Cys Thr Arg 
    610                 615                 620                 


Gly Ser Leu Gln Asp Leu Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp 
625                 630                 635                 640 


Met Phe Lys Ser Ser Leu Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr 
                645                 650                 655     


Leu His His Arg Gly Val Ala His Gly Arg Leu Lys Ser Arg Asn Cys 
            660                 665                 670         


Ile Val Asp Gly Arg Phe Val Leu Lys Ile Thr Asp His Gly His Gly 
        675                 680                 685             


Arg Leu Leu Glu Ala Gln Lys Val Leu Pro Glu Pro Pro Arg Ala Glu 
    690                 695                 700                 


Asp Gln Leu Trp Thr Ala Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu 
705                 710                 715                 720 


Arg Arg Gly Thr Leu Ala Gly Asp Val Phe Ser Leu Ala Ile Ile Met 
                725                 730                 735     


Gln Glu Val Val Cys Arg Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr 
            740                 745                 750         


Pro Glu Glu Val Val Gln Arg Val Arg Ser Pro Pro Pro Leu Cys Arg 
        755                 760                 765             


Pro Leu Val Ser Met Asp Gln Ala Pro Val Glu Cys Ile Leu Leu Met 
    770                 775                 780                 


Lys Gln Cys Trp Ala Glu Gln Pro Glu Leu Arg Pro Ser Met Asp His 
785                 790                 795                 800 


Thr Phe Asp Leu Phe Lys Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile 
                805                 810                 815     


Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu 
            820                 825                 830         


Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys 
        835                 840                 845             


Thr Asp Arg Leu Leu Thr Gln Met Leu Pro Pro Ser Val Ala Glu Ala 
    850                 855                 860                 


Leu Lys Thr Gly Thr Pro Val Glu Pro Glu Tyr Phe Glu Gln Val Thr 
865                 870                 875                 880 


Leu Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Ser Ala Met Ser 
                885                 890                 895     


Glu Pro Ile Glu Val Val Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe 
            900                 905                 910         


Asp Ala Ile Ile Gly Ser His Asp Val Tyr Lys Val Glu Thr Ile Gly 
        915                 920                 925             


Asp Ala Tyr Met Val Ala Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg 
    930                 935                 940                 


His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser Ala Val 
945                 950                 955                 960 


Gly Thr Phe Arg Met Arg His Met Pro Glu Val Pro Val Arg Ile Arg 
                965                 970                 975     


Ile Gly Leu His Ser Gly Pro Cys Val Ala Gly Val Val Gly Leu Thr 
            980                 985                 990         


Met Pro Arg Tyr Cys Leu Phe Gly  Asp Thr Val Asn Thr  Ala Ser Arg 
        995                 1000                 1005             


Met Glu  Ser Thr Gly Leu Pro  Tyr Arg Ile His Val  Asn Leu Ser 
    1010                 1015                 1020             


Thr Val  Gly Ile Leu Arg Ala  Leu Asp Ser Gly Tyr  Gln Val Glu 
    1025                 1030                 1035             


Leu Arg  Gly Arg Thr Glu Leu  Lys Gly Lys Gly Ala  Glu Asp Thr 
    1040                 1045                 1050             


Phe Trp  Leu Val Gly Arg Arg  Gly Phe Asn Lys Pro  Ile Pro Lys 
    1055                 1060                 1065             


Pro Pro  Asp Leu Gln Pro Gly  Ser Ser Asn His Gly  Ile Ser Leu 
    1070                 1075                 1080             


Gln Glu  Ile Pro Pro Glu Arg  Arg Arg Lys Leu Glu  Lys Ala Arg 
    1085                 1090                 1095             


Pro Gly  Gln Phe Ser 
    1100             


<210>  4816
<211>  1108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUCY2F__Homo_sapiens__NP_001513

<400>  4816

Met Phe Leu Gly Leu Gly Arg Phe Ser Arg Leu Val Leu Trp Phe Ala 
1               5                   10                  15      


Ala Phe Arg Lys Leu Leu Gly His His Gly Leu Ala Ser Ala Lys Phe 
            20                  25                  30          


Leu Trp Cys Leu Cys Leu Leu Ser Val Met Ser Leu Pro Gln Gln Val 
        35                  40                  45              


Trp Thr Leu Pro Tyr Lys Ile Gly Val Val Gly Pro Trp Ala Cys Asp 
    50                  55                  60                  


Ser Leu Phe Ser Lys Ala Leu Pro Glu Val Ala Ala Arg Leu Ala Ile 
65                  70                  75                  80  


Glu Arg Ile Asn Arg Asp Pro Ser Phe Asp Leu Ser Tyr Ser Phe Glu 
                85                  90                  95      


Tyr Val Ile Leu Asn Glu Asp Cys Gln Thr Ser Arg Ala Leu Ser Ser 
            100                 105                 110         


Phe Ile Ser His His Gln Met Ala Ser Gly Phe Ile Gly Pro Thr Asn 
        115                 120                 125             


Pro Gly Tyr Cys Glu Ala Ala Ser Leu Leu Gly Asn Ser Trp Asp Lys 
    130                 135                 140                 


Gly Ile Phe Ser Trp Ala Cys Val Asn Tyr Glu Leu Asp Asn Lys Ile 
145                 150                 155                 160 


Ser Tyr Pro Thr Phe Ser Arg Thr Leu Pro Ser Pro Ile Arg Val Leu 
                165                 170                 175     


Val Thr Val Met Lys Tyr Phe Gln Trp Ala His Ala Gly Val Ile Ser 
            180                 185                 190         


Ser Asp Glu Asp Ile Trp Val His Thr Ala Asn Arg Val Ala Ser Ala 
        195                 200                 205             


Leu Arg Ser His Gly Leu Pro Val Gly Val Val Leu Thr Thr Gly Gln 
    210                 215                 220                 


Asp Ser Gln Ser Met Arg Lys Ala Leu Gln Arg Ile His Gln Ala Asp 
225                 230                 235                 240 


Arg Ile Arg Ile Ile Ile Met Cys Met His Ser Ala Leu Ile Gly Gly 
                245                 250                 255     


Glu Thr Gln Met His Leu Leu Glu Cys Ala His Asp Leu Lys Met Thr 
            260                 265                 270         


Asp Gly Thr Tyr Val Phe Val Pro Tyr Asp Ala Leu Leu Tyr Ser Leu 
        275                 280                 285             


Pro Tyr Lys His Thr Pro Tyr Arg Val Leu Arg Asn Asn Pro Lys Leu 
    290                 295                 300                 


Arg Glu Ala Tyr Asp Ala Val Leu Thr Ile Thr Val Glu Ser Gln Glu 
305                 310                 315                 320 


Lys Thr Phe Tyr Gln Ala Phe Thr Glu Ala Ala Ala Arg Gly Glu Ile 
                325                 330                 335     


Pro Glu Lys Leu Glu Phe Asp Gln Val Ser Pro Leu Phe Gly Thr Ile 
            340                 345                 350         


Tyr Asn Ser Ile Tyr Phe Ile Ala Gln Ala Met Asn Asn Ala Met Lys 
        355                 360                 365             


Glu Asn Gly Gln Ala Gly Ala Ala Ser Leu Val Gln His Ser Arg Asn 
    370                 375                 380                 


Met Gln Phe His Gly Phe Asn Gln Leu Met Arg Thr Asp Ser Asn Gly 
385                 390                 395                 400 


Asn Gly Ile Ser Glu Tyr Val Ile Leu Asp Thr Asn Leu Lys Glu Trp 
                405                 410                 415     


Glu Leu His Ser Thr Tyr Thr Val Asp Met Glu Met Glu Leu Leu Arg 
            420                 425                 430         


Phe Gly Gly Thr Pro Ile His Phe Pro Gly Gly Arg Pro Pro Arg Ala 
        435                 440                 445             


Asp Ala Lys Cys Trp Phe Ala Glu Gly Lys Ile Cys His Gly Gly Ile 
    450                 455                 460                 


Asp Pro Ala Phe Ala Met Met Val Cys Leu Thr Leu Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Ser Ile Asn Gly Phe Ala Tyr Phe Ile Arg Arg Arg Ile Asn Lys 
                485                 490                 495     


Ile Gln Leu Ile Lys Gly Pro Asn Arg Ile Leu Leu Thr Leu Glu Asp 
            500                 505                 510         


Val Thr Phe Ile Asn Pro His Phe Gly Ser Lys Arg Gly Ser Arg Ala 
        515                 520                 525             


Ser Val Ser Phe Gln Ile Thr Ser Glu Val Gln Ser Gly Arg Ser Pro 
    530                 535                 540                 


Arg Leu Ser Phe Ser Ser Gly Ser Leu Thr Pro Ala Thr Tyr Glu Asn 
545                 550                 555                 560 


Ser Asn Ile Ala Ile Tyr Glu Gly Asp Trp Val Trp Leu Lys Lys Phe 
                565                 570                 575     


Ser Leu Gly Asp Phe Gly Asp Leu Lys Ser Ile Lys Ser Arg Ala Ser 
            580                 585                 590         


Asp Val Phe Glu Met Met Lys Asp Leu Arg His Glu Asn Ile Asn Pro 
        595                 600                 605             


Leu Leu Gly Phe Phe Tyr Asp Ser Gly Met Phe Ala Ile Val Thr Glu 
    610                 615                 620                 


Phe Cys Ser Arg Gly Ser Leu Glu Asp Ile Leu Thr Asn Gln Asp Val 
625                 630                 635                 640 


Lys Leu Asp Trp Met Phe Lys Ser Ser Leu Leu Leu Asp Leu Ile Lys 
                645                 650                 655     


Gly Met Lys Tyr Leu His His Arg Glu Phe Val His Gly Arg Leu Lys 
            660                 665                 670         


Ser Arg Asn Cys Val Val Asp Gly Arg Phe Val Leu Lys Val Thr Asp 
        675                 680                 685             


Tyr Gly Phe Asn Asp Ile Leu Glu Met Leu Arg Leu Ser Glu Glu Glu 
    690                 695                 700                 


Ser Ser Met Glu Glu Leu Leu Trp Thr Ala Pro Glu Leu Leu Arg Ala 
705                 710                 715                 720 


Pro Arg Gly Ser Arg Leu Gly Ser Phe Ala Gly Asp Val Tyr Ser Phe 
                725                 730                 735     


Ala Ile Ile Met Gln Glu Val Met Val Arg Gly Thr Pro Phe Cys Met 
            740                 745                 750         


Met Asp Leu Pro Ala Gln Glu Ile Ile Asn Arg Leu Lys Lys Pro Pro 
        755                 760                 765             


Pro Val Tyr Arg Pro Val Val Pro Pro Glu His Ala Pro Pro Glu Cys 
    770                 775                 780                 


Leu Gln Leu Met Lys Gln Cys Trp Ala Glu Ala Ala Glu Gln Arg Pro 
785                 790                 795                 800 


Thr Phe Asp Glu Ile Phe Asn Gln Phe Lys Thr Phe Asn Lys Gly Lys 
                805                 810                 815     


Lys Thr Asn Ile Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser 
            820                 825                 830         


Ser Asn Leu Glu Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Ile 
        835                 840                 845             


Glu Lys Gln Lys Thr Glu Lys Leu Leu Thr Gln Met Leu Pro Pro Ser 
    850                 855                 860                 


Val Ala Glu Ser Leu Lys Lys Gly Cys Thr Val Glu Pro Glu Gly Phe 
865                 870                 875                 880 


Asp Leu Val Thr Leu Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile 
                885                 890                 895     


Ser Ala Met Ser Glu Pro Ile Glu Val Val Asp Leu Leu Asn Asp Leu 
            900                 905                 910         


Tyr Thr Leu Phe Asp Ala Ile Ile Gly Ser His Asp Val Tyr Lys Val 
        915                 920                 925             


Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly Leu Pro Lys Arg 
    930                 935                 940                 


Asn Gly Ser Arg His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile 
945                 950                 955                 960 


Leu Ser Ser Val Gly Thr Phe Lys Met Arg His Met Pro Glu Val Pro 
                965                 970                 975     


Val Arg Ile Arg Ile Gly Leu His Ser Gly Pro Val Val Ala Gly Val 
            980                 985                 990         


Val Gly Leu Thr Met Pro Arg Tyr  Cys Leu Phe Gly Asp  Thr Val Asn 
        995                 1000                 1005             


Thr Ala  Ser Arg Met Glu Ser  Thr Gly Leu Pro Tyr  Arg Ile His 
    1010                 1015                 1020             


Val Ser  Leu Ser Thr Val Thr  Ile Leu Gln Asn Leu  Ser Glu Gly 
    1025                 1030                 1035             


Tyr Glu  Val Glu Leu Arg Gly  Arg Thr Glu Leu Lys  Gly Lys Gly 
    1040                 1045                 1050             


Thr Glu  Glu Thr Phe Trp Leu  Ile Gly Lys Lys Gly  Phe Met Lys 
    1055                 1060                 1065             


Pro Leu  Pro Val Pro Pro Pro  Val Asp Lys Asp Gly  Gln Val Gly 
    1070                 1075                 1080             


His Gly  Leu Gln Pro Val Glu  Ile Ala Ala Phe Gln  Arg Arg Lys 
    1085                 1090                 1095             


Ala Glu  Arg Gln Leu Val Arg  Asn Lys Pro 
    1100                 1105             


<210>  4817
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUK1__Homo_sapiens__NP_001152862

<400>  4817

Met Leu Arg Arg Pro Leu Ala Gly Leu Ala Ala Ala Ala Leu Gly Arg 
1               5                   10                  15      


Ala Pro Pro Asp Gly Met Ser Gly Pro Arg Pro Val Val Leu Ser Gly 
            20                  25                  30          


Pro Ser Gly Ala Gly Lys Ser Thr Leu Leu Lys Arg Leu Leu Gln Glu 
        35                  40                  45              


His Ser Gly Ile Phe Gly Phe Ser Val Ser His Thr Thr Arg Asn Pro 
    50                  55                  60                  


Arg Pro Gly Glu Glu Asn Gly Lys Asp Tyr Tyr Phe Val Thr Arg Glu 
65                  70                  75                  80  


Val Met Gln Arg Asp Ile Ala Ala Gly Asp Phe Ile Glu His Ala Glu 
                85                  90                  95      


Phe Ser Gly Asn Leu Tyr Gly Thr Ser Lys Val Ala Val Gln Ala Val 
            100                 105                 110         


Gln Ala Met Asn Arg Ile Cys Val Leu Asp Val Asp Leu Gln Gly Val 
        115                 120                 125             


Arg Asn Ile Lys Ala Thr Asp Leu Arg Pro Ile Tyr Ile Ser Val Gln 
    130                 135                 140                 


Pro Pro Ser Leu His Val Leu Glu Gln Arg Leu Arg Gln Arg Asn Thr 
145                 150                 155                 160 


Glu Thr Glu Glu Ser Leu Val Lys Arg Leu Ala Ala Ala Gln Ala Asp 
                165                 170                 175     


Met Glu Ser Ser Lys Glu Pro Gly Leu Phe Asp Val Val Ile Ile Asn 
            180                 185                 190         


Asp Ser Leu Asp Gln Ala Tyr Ala Glu Leu Lys Glu Ala Leu Ser Glu 
        195                 200                 205             


Glu Ile Lys Lys Ala Gln Arg Thr Gly Ala 
    210                 215             


<210>  4818
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GULP1__Homo_sapiens__NP_001239597

<400>  4818

Met Asn Arg Ala Phe Ser Arg Lys Lys Asp Lys Thr Trp Met His Thr 
1               5                   10                  15      


Pro Glu Ala Leu Ser Lys His Phe Ile Pro Tyr Asn Ala Lys Phe Leu 
            20                  25                  30          


Gly Ser Thr Glu Val Glu Gln Pro Lys Gly Thr Glu Val Val Arg Asp 
        35                  40                  45              


Ala Val Arg Lys Leu Lys Phe Ala Arg His Ile Lys Lys Ser Glu Gly 
    50                  55                  60                  


Gln Lys Ile Pro Lys Val Glu Leu Gln Ile Ser Ile Tyr Gly Val Lys 
65                  70                  75                  80  


Ile Leu Glu Pro Lys Thr Lys Glu Val Gln His Asn Cys Gln Leu His 
                85                  90                  95      


Arg Ile Ser Phe Cys Ala Asp Asp Lys Thr Asp Lys Arg Ile Phe Thr 
            100                 105                 110         


Phe Ile Cys Lys Asp Ser Glu Ser Asn Lys His Leu Cys Tyr Val Phe 
        115                 120                 125             


Asp Ser Glu Lys Cys Ala Glu Glu Ile Thr Leu Thr Ile Gly Gln Ala 
    130                 135                 140                 


Phe Asp Leu Ala Tyr Arg Lys Phe Leu Glu Ser Gly Gly Lys Asp Val 
145                 150                 155                 160 


Glu Thr Arg Lys Gln Ile Ala Gly Leu Gln Lys Arg Ile Gln Asp Leu 
                165                 170                 175     


Glu Thr Glu Asn Met Glu Leu Lys Asn Lys Val Gln Asp Leu Glu Asn 
            180                 185                 190         


Gln Leu Arg Ile Thr Gln Val Ser Ala Pro Pro Ala Gly Ser Met Thr 
        195                 200                 205             


Pro Lys Ser Pro Ser Thr Asp Ile Phe Asp Met Ile Pro Phe Ser Pro 
    210                 215                 220                 


Ile Ser His Gln Ser Ser Met Pro Thr Arg Asn Gly Thr Gln Pro Pro 
225                 230                 235                 240 


Pro Val Pro Ser Arg Ser Thr Glu Ile Lys Arg Asp Leu Phe Gly Ala 
                245                 250                 255     


Glu Pro Phe Asp Pro Phe Asn Cys Gly Ala Ala Asp Phe Pro Pro Asp 
            260                 265                 270         


Ile Gln Ser Lys Leu Asp Glu Met Gln Arg Gln Arg Trp Arg Gly Ser 
        275                 280                 285             


Lys Trp Asp 
    290     


<210>  4819
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GUSB__Homo_sapiens__NP_000172

<400>  4819

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Leu Phe Thr 
                645                 650     


<210>  4820
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYG1__Homo_sapiens__NP_001171649

<400>  4820

Met Thr Asp Gln Ala Phe Val Thr Leu Thr Thr Asn Asp Ala Tyr Ala 
1               5                   10                  15      


Lys Gly Ala Leu Val Leu Gly Ser Ser Leu Lys Gln His Arg Thr Thr 
            20                  25                  30          


Arg Arg Leu Val Val Leu Ala Thr Pro Gln Val Ser Asp Ser Met Arg 
        35                  40                  45              


Lys Val Leu Glu Thr Val Phe Asp Glu Val Ile Met Val Asp Val Leu 
    50                  55                  60                  


Asp Ser Gly Asp Ser Ala His Leu Thr Leu Met Lys Arg Pro Glu Leu 
65                  70                  75                  80  


Gly Val Thr Leu Thr Lys Leu His Cys Trp Ser Leu Thr Gln Tyr Ser 
                85                  90                  95      


Lys Cys Val Phe Met Asp Ala Asp Thr Leu Val Leu Ala Asn Ile Asp 
            100                 105                 110         


Asp Leu Phe Asp Arg Glu Glu Leu Ser Ala Ala Pro Asp Pro Gly Trp 
        115                 120                 125             


Pro Asp Cys Phe Asn Ser Gly Val Phe Val Tyr Gln Pro Ser Val Glu 
    130                 135                 140                 


Thr Tyr Asn Gln Leu Leu His Leu Ala Ser Glu Gln Gly Ser Phe Asp 
145                 150                 155                 160 


Gly Gly Asp Gln Gly Ile Leu Asn Thr Phe Phe Ser Ser Trp Ala Thr 
                165                 170                 175     


Thr Asp Ile Arg Lys His Leu Pro Phe Ile Tyr Asn Leu Ser Ser Ile 
            180                 185                 190         


Ser Ile Tyr Ser Tyr Leu Pro Ala Phe Lys Val Phe Gly Ala Ser Ala 
        195                 200                 205             


Lys Val Val His Phe Leu Gly Arg Val Lys Pro Trp Asn Tyr Thr Tyr 
    210                 215                 220                 


Asp Pro Lys Thr Lys Ser Val Lys Ser Glu Ala His Asp Pro Asn Met 
225                 230                 235                 240 


Thr His Pro Glu Phe Leu Ile Leu Trp Trp Asn Ile Phe Thr Thr Asn 
                245                 250                 255     


Val Leu Pro Leu Leu Gln Gln Phe Gly Leu Val Lys Asp Thr Cys Ser 
            260                 265                 270         


Tyr Val Asn Val Glu Asp Val Ser Gly Ala Ile Ser His Leu Ser Leu 
        275                 280                 285             


Gly Glu Ile Pro Ala Met Ala Gln Pro Phe Val Ser Ser Glu Glu Arg 
    290                 295                 300                 


Lys Glu Arg Trp Glu Gln Gly Gln Ala Asp Tyr Met Gly Ala Asp Ser 
305                 310                 315                 320 


Phe Asp Asn Ile Lys Arg Lys Leu Asp Thr Tyr Leu Gln 
                325                 330             


<210>  4821
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYG2__Homo_sapiens__NP_001073324

<400>  4821

Met Ser Val Thr Asp Gln Ala Phe Val Thr Leu Ala Thr Asn Asp Ile 
1               5                   10                  15      


Tyr Cys Gln Gly Ala Leu Val Leu Gly Gln Ser Leu Arg Arg His Arg 
            20                  25                  30          


Leu Thr Arg Lys Leu Val Val Leu Ile Thr Pro Gln Val Ser Ser Leu 
        35                  40                  45              


Leu Arg Val Ile Leu Ser Lys Val Phe Asp Glu Val Ile Glu Val Asn 
    50                  55                  60                  


Leu Ile Asp Ser Ala Asp Tyr Ile His Leu Ala Phe Leu Lys Arg Pro 
65                  70                  75                  80  


Glu Leu Gly Leu Thr Leu Thr Lys Leu His Cys Trp Thr Leu Thr His 
                85                  90                  95      


Tyr Ser Lys Cys Val Phe Leu Asp Ala Asp Thr Leu Val Leu Ser Asn 
            100                 105                 110         


Val Asp Glu Leu Phe Asp Arg Gly Glu Phe Ser Ala Ala Pro Asp Pro 
        115                 120                 125             


Gly Trp Pro Asp Cys Phe Asn Ser Gly Val Phe Val Phe Gln Pro Ser 
    130                 135                 140                 


Leu His Thr His Lys Leu Leu Leu Gln His Ala Met Glu His Gly Ser 
145                 150                 155                 160 


Phe Asp Gly Ala Asp Gln Gly Leu Leu Asn Ser Phe Phe Arg Asn Trp 
                165                 170                 175     


Ser Thr Thr Asp Ile His Lys His Leu Pro Phe Ile Tyr Asn Leu Ser 
            180                 185                 190         


Ser Asn Thr Met Tyr Thr Tyr Ser Pro Ala Phe Lys Gln Phe Gly Ser 
        195                 200                 205             


Ser Ala Lys Val Val His Phe Leu Gly Ser Met Lys Pro Trp Asn Tyr 
    210                 215                 220                 


Lys Tyr Asn Pro Gln Ser Gly Ser Val Leu Glu Gln Gly Ser Ala Ser 
225                 230                 235                 240 


Ser Ser Gln His Gln Ala Ala Phe Leu His Leu Trp Trp Thr Val Tyr 
                245                 250                 255     


Gln Asn Asn Val Leu Pro Leu Tyr Lys Ser Val Gln Ala Gly Glu Ala 
            260                 265                 270         


Arg Ala Ser Pro Gly His Thr Leu Cys His Ser Asp Val Gly Gly Pro 
        275                 280                 285             


Cys Ala Asp Ser Ala Ser Gly Val Gly Glu Pro Cys Glu Asn Ser Thr 
    290                 295                 300                 


Pro Ser Ala Gly Val Pro Cys Ala Asn Ser Pro Leu Gly Ser Asn Gln 
305                 310                 315                 320 


Pro Ala Gln Gly Leu Pro Glu Pro Thr Gln Ile Val Asp Glu Thr Leu 
                325                 330                 335     


Ser Leu Pro Glu Gly Arg Arg Ser Glu Asp Met Ile Ala Cys Pro Glu 
            340                 345                 350         


Thr Glu Thr Pro Ala Val Ile Thr Cys Asp Pro Leu Ser Gln Pro Ser 
        355                 360                 365             


Pro Gln Pro Ala Asp Phe Thr Glu Thr Glu Thr Ile Leu Gln Pro Ala 
    370                 375                 380                 


Asn Lys Val Glu Ser Val Ser Ser Glu Glu Thr Phe Glu Pro Ser Gln 
385                 390                 395                 400 


Glu Leu Pro Ala Glu Ala Leu Arg Asp Pro Ser Leu Gln Asp Ala Leu 
                405                 410                 415     


Glu Val Asp Leu Ala Val Ser Val Ser Gln Ile Ser Ile Glu Glu Lys 
            420                 425                 430         


Val Lys Glu Leu Ser Pro Glu Glu Glu Arg Arg Lys Trp Glu Glu Gly 
        435                 440                 445             


Arg Ile Asp Tyr Met Gly Lys Asp Ala Phe Ala Arg Ile Gln Glu Lys 
    450                 455                 460                 


Leu Asp Arg Phe Leu Gln 
465                 470 


<210>  4822
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYLTL1B__Homo_sapiens__NP_001287650

<400>  4822

Met Leu Pro Arg Gly Arg Pro Arg Ala Leu Gly Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gly Phe Leu Leu Phe Gly Gly Asp Leu Gly 
            20                  25                  30          


Cys Glu Arg Arg Glu Pro Gly Gly Arg Ala Gly Ala Pro Gly Cys Phe 
        35                  40                  45              


Pro Gly Pro Leu Met Pro Arg Val Pro Pro Asp Gly Arg Leu Arg Arg 
    50                  55                  60                  


Ala Ala Ala Leu Asp Gly Asp Pro Gly Ala Gly Pro Gly Asp His Asn 
65                  70                  75                  80  


Arg Ser Asp Cys Gly Pro Gln Pro Pro Pro Pro Pro Lys Cys Glu Leu 
                85                  90                  95      


Leu His Val Ala Ile Val Cys Ala Gly His Asn Ser Ser Arg Asp Val 
            100                 105                 110         


Ile Thr Leu Val Lys Ser Met Leu Phe Tyr Arg Lys Asn Pro Leu His 
        115                 120                 125             


Leu His Leu Val Thr Asp Ala Val Ala Arg Asn Ile Leu Glu Thr Leu 
    130                 135                 140                 


Phe His Thr Trp Met Val Pro Ala Val Arg Val Ser Phe Tyr His Ala 
145                 150                 155                 160 


Asp Gln Leu Lys Pro Gln Val Ser Trp Ile Pro Asn Lys His Tyr Ser 
                165                 170                 175     


Gly Leu Tyr Gly Leu Met Lys Leu Val Leu Pro Ser Ala Leu Pro Ala 
            180                 185                 190         


Glu Leu Ala Arg Val Ile Val Leu Asp Thr Asp Val Thr Phe Ala Ser 
        195                 200                 205             


Asp Ile Ser Glu Leu Trp Ala Leu Phe Ala His Phe Ser Asp Thr Gln 
    210                 215                 220                 


Ala Ile Gly Leu Val Glu Asn Gln Ser Asp Trp Tyr Leu Gly Asn Leu 
225                 230                 235                 240 


Trp Lys Asn His Arg Pro Trp Pro Ala Leu Gly Arg Gly Phe Asn Thr 
                245                 250                 255     


Gly Val Ile Leu Leu Arg Leu Asp Arg Leu Arg Gln Ala Gly Trp Glu 
            260                 265                 270         


Gln Met Trp Arg Leu Thr Ala Arg Arg Glu Leu Leu Ser Leu Pro Ala 
        275                 280                 285             


Thr Ser Leu Ala Asp Gln Asp Ile Phe Asn Ala Val Ile Lys Glu His 
    290                 295                 300                 


Pro Gly Leu Val Gln Arg Leu Pro Cys Val Trp Asn Val Gln Leu Ser 
305                 310                 315                 320 


Asp His Thr Leu Ala Glu Arg Cys Tyr Ser Glu Ala Ser Asp Leu Lys 
                325                 330                 335     


Val Ile His Trp Asn Ser Pro Lys Lys Leu Arg Val Lys Asn Lys His 
            340                 345                 350         


Val Glu Phe Phe Arg Asn Phe Tyr Leu Thr Phe Leu Glu Tyr Asp Gly 
        355                 360                 365             


Asn Leu Leu Arg Arg Glu Leu Phe Val Cys Pro Ser Gln Pro Pro Pro 
    370                 375                 380                 


Gly Ala Glu Gln Leu Gln Gln Ala Leu Ala Gln Leu Asp Glu Glu Asp 
385                 390                 395                 400 


Pro Cys Phe Glu Phe Arg Gln Gln Gln Leu Thr Val His Arg Val His 
                405                 410                 415     


Val Thr Phe Leu Pro His Glu Pro Pro Pro Pro Arg Pro His Asp Val 
            420                 425                 430         


Thr Leu Val Ala Gln Leu Ser Met Asp Arg Leu Gln Met Leu Glu Ala 
        435                 440                 445             


Leu Cys Arg His Trp Pro Gly Pro Met Ser Leu Ala Leu Tyr Leu Thr 
    450                 455                 460                 


Asp Ala Glu Ala Gln Gln Phe Leu His Phe Val Glu Ala Ser Pro Val 
465                 470                 475                 480 


Leu Ala Ala Arg Gln Asp Val Ala Tyr His Val Val Tyr Arg Glu Gly 
                485                 490                 495     


Pro Leu Tyr Pro Val Asn Gln Leu Arg Asn Val Ala Leu Ala Gln Ala 
            500                 505                 510         


Leu Thr Pro Tyr Val Phe Leu Ser Asp Ile Asp Phe Leu Pro Ala Tyr 
        515                 520                 525             


Ser Leu Tyr Asp Tyr Leu Arg Ala Ser Ile Glu Gln Leu Gly Leu Gly 
    530                 535                 540                 


Ser Arg Arg Lys Ala Ala Leu Val Val Pro Ala Phe Glu Thr Leu Arg 
545                 550                 555                 560 


Tyr Arg Phe Ser Phe Pro His Ser Lys Val Glu Leu Leu Ala Leu Leu 
                565                 570                 575     


Asp Ala Gly Thr Leu Tyr Thr Phe Arg Tyr His Glu Trp Pro Arg Gly 
            580                 585                 590         


His Ala Pro Thr Asp Tyr Ala Arg Trp Arg Glu Ala Gln Ala Pro Tyr 
        595                 600                 605             


Arg Val Gln Trp Ala Ala Asn Tyr Glu Pro Tyr Val Val Val Pro Arg 
    610                 615                 620                 


Asp Cys Pro Arg Tyr Asp Pro Arg Phe Val Gly Phe Gly Trp Asn Lys 
625                 630                 635                 640 


Val Ala His Ile Val Glu Leu Asp Ala Gln Glu Tyr Glu Leu Leu Val 
                645                 650                 655     


Leu Pro Glu Ala Phe Thr Ile His Leu Pro His Ala Pro Ser Leu Asp 
            660                 665                 670         


Ile Ser Arg Phe Arg Ser Ser Pro Thr Tyr Arg Asp Cys Leu Gln Ala 
        675                 680                 685             


Leu Lys Asp Glu Phe His Gln Asp Leu Ser Arg His His Gly Ala Ala 
    690                 695                 700                 


Ala Leu Lys Tyr Leu Pro Ala Leu Gln Gln Pro Gln Ser Pro Ala Arg 
705                 710                 715                 720 


Gly 
    


<210>  4823
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYPA__Homo_sapiens__NP_002090

<400>  4823

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
65                  70                  75                  80  


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
                85                  90                  95      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            100                 105                 110         


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
        115                 120                 125             


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
    130                 135                 140                 


Pro Glu Thr Ser Asp Gln 
145                 150 


<210>  4824
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYPB__Homo_sapiens__NP_002091

<400>  4824

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Glu Thr 
        35                  40                  45              


Gly Gln Leu Val His Arg Phe Thr Val Pro Ala Pro Val Val Ile Ile 
    50                  55                  60                  


Leu Ile Ile Leu Cys Val Met Ala Gly Ile Ile Gly Thr Ile Leu Leu 
65                  70                  75                  80  


Ile Ser Tyr Thr Ile Arg Arg Leu Ile Lys Ala 
                85                  90      


<210>  4825
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYPC__Homo_sapiens__NP_001243513

<400>  4825

Met Ala Ser Ala Ser Thr Thr Met His Thr Thr Thr Ile Ala Glu Pro 
1               5                   10                  15      


Asp Pro Gly Met Ser Gly Trp Pro Asp Gly Arg Met Glu Thr Ser Thr 
            20                  25                  30          


Pro Thr Ile Met Asp Ile Val Val Ile Ala Gly Val Ile Ala Ala Val 
        35                  40                  45              


Ala Ile Val Leu Val Ser Leu Leu Phe Val Met Leu Arg Tyr Met Tyr 
    50                  55                  60                  


Arg His Lys Gly Thr Tyr His Thr Asn Glu Ala Lys Gly Thr Glu Phe 
65                  70                  75                  80  


Ala Glu Ser Ala Asp Ala Ala Leu Gln Gly Asp Pro Ala Leu Gln Asp 
                85                  90                  95      


Ala Gly Asp Ser Ser Arg Lys Glu Tyr Phe Ile 
            100                 105         


<210>  4826
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYPE__Homo_sapiens__NP_002093

<400>  4826

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Gly Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ser Ser Thr Thr Gly Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Ile Thr 
        35                  40                  45              


Leu Ile Asn Trp Trp Ala Met Ala Arg Val Ile Phe Glu Val Met Leu 
    50                  55                  60                  


Val Val Val Gly Met Ile Ile Leu Ile Ser Tyr Cys Ile Arg 
65                  70                  75              


<210>  4827
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYS1__Homo_sapiens__NP_001155059

<400>  4827

Met Pro Leu Asn Arg Thr Leu Ser Met Ser Ser Leu Pro Gly Leu Glu 
1               5                   10                  15      


Asp Trp Glu Asp Glu Phe Asp Leu Glu Asn Ala Val Leu Phe Glu Val 
            20                  25                  30          


Ala Trp Glu Val Ala Asn Lys Val Gly Gly Ile Tyr Thr Val Leu Gln 
        35                  40                  45              


Thr Lys Ala Lys Val Thr Gly Asp Glu Trp Gly Asp Asn Tyr Phe Leu 
    50                  55                  60                  


Val Gly Pro Tyr Thr Glu Gln Gly Val Arg Thr Gln Val Glu Leu Leu 
65                  70                  75                  80  


Glu Ala Pro Thr Pro Ala Leu Lys Arg Thr Leu Asp Ser Met Asn Ser 
                85                  90                  95      


Lys Gly Cys Lys Phe Leu Ala Gln Ser Glu Glu Lys Pro His Val Val 
            100                 105                 110         


Ala His Phe His Glu Trp Leu Ala Gly Val Gly Leu Cys Leu Cys Arg 
        115                 120                 125             


Ala Arg Arg Leu Pro Val Ala Thr Ile Phe Thr Thr His Ala Thr Leu 
    130                 135                 140                 


Leu Gly Arg Tyr Leu Cys Ala Gly Ala Val Asp Phe Tyr Asn Asn Leu 
145                 150                 155                 160 


Glu Asn Phe Asn Val Asp Lys Glu Ala Gly Glu Arg Gln Ile Tyr His 
                165                 170                 175     


Arg Tyr Cys Met Glu Arg Ala Ala Ala His Cys Ala His Val Phe Thr 
            180                 185                 190         


Thr Val Ser Gln Ile Thr Ala Ile Glu Ala Gln His Leu Leu Lys Arg 
        195                 200                 205             


Lys Pro Asp Ile Val Thr Pro Asn Gly Leu Asn Val Lys Lys Phe Ser 
    210                 215                 220                 


Ala Met His Glu Phe Gln Asn Leu His Ala Gln Ser Lys Ala Arg Ile 
225                 230                 235                 240 


Gln Glu Phe Val Arg Gly His Phe Tyr Gly His Leu Asp Phe Asn Leu 
                245                 250                 255     


Asp Lys Thr Leu Tyr Phe Phe Ile Ala Gly Arg Tyr Glu Phe Ser Asn 
            260                 265                 270         


Lys Gly Ala Asp Val Phe Leu Glu Ala Leu Ala Arg Leu Asn Tyr Leu 
        275                 280                 285             


Leu Arg Val Asn Gly Ser Glu Gln Thr Val Val Ala Phe Phe Ile Met 
    290                 295                 300                 


Pro Ala Arg Thr Asn Asn Phe Asn Val Glu Thr Leu Lys Gly Gln Ala 
305                 310                 315                 320 


Val Arg Lys Gln Leu Trp Asp Thr Ala Asn Thr Val Lys Glu Lys Phe 
                325                 330                 335     


Gly Arg Lys Leu Tyr Glu Ser Leu Leu Val Gly Ser Leu Pro Asp Met 
            340                 345                 350         


Asn Lys Met Leu Asp Lys Glu Asp Phe Thr Met Met Lys Arg Ala Ile 
        355                 360                 365             


Phe Ala Thr Gln Arg Gln Ser Phe Pro Pro Val Cys Thr His Asn Met 
    370                 375                 380                 


Leu Asp Asp Ser Ser Asp Pro Ile Leu Thr Thr Ile Arg Arg Ile Gly 
385                 390                 395                 400 


Leu Phe Asn Ser Ser Ala Asp Arg Val Lys Val Ile Phe His Pro Glu 
                405                 410                 415     


Phe Leu Ser Ser Thr Ser Pro Leu Leu Pro Val Asp Tyr Glu Glu Phe 
            420                 425                 430         


Val Arg Gly Cys His Leu Gly Val Phe Pro Ser Tyr Tyr Glu Pro Trp 
        435                 440                 445             


Gly Tyr Thr Pro Ala Glu Cys Thr Val Met Gly Ile Pro Ser Ile Ser 
    450                 455                 460                 


Thr Asn Leu Ser Gly Phe Gly Cys Phe Met Glu Glu His Ile Ala Asp 
465                 470                 475                 480 


Pro Ser Ala Tyr Gly Ile Tyr Ile Leu Asp Arg Arg Phe Arg Ser Leu 
                485                 490                 495     


Asp Asp Ser Cys Ser Gln Leu Thr Ser Phe Leu Tyr Ser Phe Cys Gln 
            500                 505                 510         


Gln Ser Arg Arg Gln Arg Ile Ile Gln Arg Asn Arg Thr Glu Arg Leu 
        515                 520                 525             


Ser Asp Leu Leu Asp Trp Lys Tyr Leu Gly Arg Tyr Tyr Met Ser Ala 
    530                 535                 540                 


Arg His Met Ala Leu Ser Lys Ala Phe Pro Glu His Phe Thr Tyr Glu 
545                 550                 555                 560 


Pro Asn Glu Ala Asp Ala Ala Gln Gly Tyr Arg Tyr Pro Arg Pro Ala 
                565                 570                 575     


Ser Val Pro Pro Ser Pro Ser Leu Ser Arg His Ser Ser Pro His Gln 
            580                 585                 590         


Ser Glu Asp Glu Glu Asp Pro Arg Asn Gly Pro Leu Glu Glu Asp Gly 
        595                 600                 605             


Glu Arg Tyr Asp Glu Asp Glu Glu Ala Ala Lys Asp Arg Arg Asn Ile 
    610                 615                 620                 


Arg Ala Pro Glu Trp Pro Arg Arg Ala Ser Cys Thr Ser Ser Thr Ser 
625                 630                 635                 640 


Gly Ser Lys Arg Asn Ser Val Asp Thr Ala Thr Ser Ser Ser Leu Ser 
                645                 650                 655     


Thr Pro Ser Glu Pro Leu Ser Pro Thr Ser Ser Leu Gly Glu Glu Arg 
            660                 665                 670         


Asn 
    


<210>  4828
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GYS2__Homo_sapiens__NP_068776

<400>  4828

Met Leu Arg Gly Arg Ser Leu Ser Val Thr Ser Leu Gly Gly Leu Pro 
1               5                   10                  15      


Gln Trp Glu Val Glu Glu Leu Pro Val Glu Glu Leu Leu Leu Phe Glu 
            20                  25                  30          


Val Ala Trp Glu Val Thr Asn Lys Val Gly Gly Ile Tyr Thr Val Ile 
        35                  40                  45              


Gln Thr Lys Ala Lys Thr Thr Ala Asp Glu Trp Gly Glu Asn Tyr Phe 
    50                  55                  60                  


Leu Ile Gly Pro Tyr Phe Glu His Asn Met Lys Thr Gln Val Glu Gln 
65                  70                  75                  80  


Cys Glu Pro Val Asn Asp Ala Val Arg Arg Ala Val Asp Ala Met Asn 
                85                  90                  95      


Lys His Gly Cys Gln Val His Phe Gly Arg Trp Leu Ile Glu Gly Ser 
            100                 105                 110         


Pro Tyr Val Val Leu Phe Asp Ile Gly Tyr Ser Ala Trp Asn Leu Asp 
        115                 120                 125             


Arg Trp Lys Gly Asp Leu Trp Glu Ala Cys Ser Val Gly Ile Pro Tyr 
    130                 135                 140                 


His Asp Arg Glu Ala Asn Asp Met Leu Ile Phe Gly Ser Leu Thr Ala 
145                 150                 155                 160 


Trp Phe Leu Lys Glu Val Thr Asp His Ala Asp Gly Lys Tyr Val Val 
                165                 170                 175     


Ala Gln Phe His Glu Trp Gln Ala Gly Ile Gly Leu Ile Leu Ser Arg 
            180                 185                 190         


Ala Arg Lys Leu Pro Ile Ala Thr Ile Phe Thr Thr His Ala Thr Leu 
        195                 200                 205             


Leu Gly Arg Tyr Leu Cys Ala Ala Asn Ile Asp Phe Tyr Asn His Leu 
    210                 215                 220                 


Asp Lys Phe Asn Ile Asp Lys Glu Ala Gly Glu Arg Gln Ile Tyr His 
225                 230                 235                 240 


Arg Tyr Cys Met Glu Arg Ala Ser Val His Cys Ala His Val Phe Thr 
                245                 250                 255     


Thr Val Ser Glu Ile Thr Ala Ile Glu Ala Glu His Met Leu Lys Arg 
            260                 265                 270         


Lys Pro Asp Val Val Thr Pro Asn Gly Leu Asn Val Lys Lys Phe Ser 
        275                 280                 285             


Ala Val His Glu Phe Gln Asn Leu His Ala Met Tyr Lys Ala Arg Ile 
    290                 295                 300                 


Gln Asp Phe Val Arg Gly His Phe Tyr Gly His Leu Asp Phe Asp Leu 
305                 310                 315                 320 


Glu Lys Thr Leu Phe Leu Phe Ile Ala Gly Arg Tyr Glu Phe Ser Asn 
                325                 330                 335     


Lys Gly Ala Asp Ile Phe Leu Glu Ser Leu Ser Arg Leu Asn Phe Leu 
            340                 345                 350         


Leu Arg Met His Lys Ser Asp Ile Thr Val Met Val Phe Phe Ile Met 
        355                 360                 365             


Pro Ala Lys Thr Asn Asn Phe Asn Val Glu Thr Leu Lys Gly Gln Ala 
    370                 375                 380                 


Val Arg Lys Gln Leu Trp Asp Val Ala His Ser Val Lys Glu Lys Phe 
385                 390                 395                 400 


Gly Lys Lys Leu Tyr Asp Ala Leu Leu Arg Gly Glu Ile Pro Asp Leu 
                405                 410                 415     


Asn Asp Ile Leu Asp Arg Asp Asp Leu Thr Ile Met Lys Arg Ala Ile 
            420                 425                 430         


Phe Ser Thr Gln Arg Gln Ser Leu Pro Pro Val Thr Thr His Asn Met 
        435                 440                 445             


Ile Asp Asp Ser Thr Asp Pro Ile Leu Ser Thr Ile Arg Arg Ile Gly 
    450                 455                 460                 


Leu Phe Asn Asn Arg Thr Asp Arg Val Lys Val Ile Leu His Pro Glu 
465                 470                 475                 480 


Phe Leu Ser Ser Thr Ser Pro Leu Leu Pro Met Asp Tyr Glu Glu Phe 
                485                 490                 495     


Val Arg Gly Cys His Leu Gly Val Phe Pro Ser Tyr Tyr Glu Pro Trp 
            500                 505                 510         


Gly Tyr Thr Pro Ala Glu Cys Thr Val Met Gly Ile Pro Ser Val Thr 
        515                 520                 525             


Thr Asn Leu Ser Gly Phe Gly Cys Phe Met Gln Glu His Val Ala Asp 
    530                 535                 540                 


Pro Thr Ala Tyr Gly Ile Tyr Ile Val Asp Arg Arg Phe Arg Ser Pro 
545                 550                 555                 560 


Asp Asp Ser Cys Asn Gln Leu Thr Lys Phe Leu Tyr Gly Phe Cys Lys 
                565                 570                 575     


Gln Ser Arg Arg Gln Arg Ile Ile Gln Arg Asn Arg Thr Glu Arg Leu 
            580                 585                 590         


Ser Asp Leu Leu Asp Trp Arg Tyr Leu Gly Arg Tyr Tyr Gln His Ala 
        595                 600                 605             


Arg His Leu Thr Leu Ser Arg Ala Phe Pro Asp Lys Phe His Val Glu 
    610                 615                 620                 


Leu Thr Ser Pro Pro Thr Thr Glu Gly Phe Lys Tyr Pro Arg Pro Ser 
625                 630                 635                 640 


Ser Val Pro Pro Ser Pro Ser Gly Ser Gln Ala Ser Ser Pro Gln Ser 
                645                 650                 655     


Ser Asp Val Glu Asp Glu Val Glu Asp Glu Arg Tyr Asp Glu Glu Glu 
            660                 665                 670         


Glu Ala Glu Arg Asp Arg Leu Asn Ile Lys Ser Pro Phe Ser Leu Ser 
        675                 680                 685             


His Val Pro His Gly Lys Lys Lys Leu His Gly Glu Tyr Lys Asn 
    690                 695                 700             


<210>  4829
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GZF1__Homo_sapiens__XP_005260860

<400>  4829

Met Glu Ser Gly Ala Val Leu Leu Glu Ser Lys Ser Ser Pro Phe Asn 
1               5                   10                  15      


Leu Leu His Glu Met His Glu Leu Arg Leu Leu Gly His Leu Cys Asp 
            20                  25                  30          


Val Thr Val Ser Val Glu Tyr Gln Gly Val Arg Lys Asp Phe Met Ala 
        35                  40                  45              


His Lys Ala Val Leu Ala Ala Thr Ser Lys Phe Phe Lys Glu Val Phe 
    50                  55                  60                  


Leu Asn Glu Lys Ser Val Asp Gly Thr Arg Thr Asn Val Tyr Leu Asn 
65                  70                  75                  80  


Glu Val Gln Val Ala Asp Phe Ala Ser Phe Leu Glu Phe Val Tyr Thr 
                85                  90                  95      


Ala Lys Val Gln Val Glu Glu Asp Arg Val Gln Arg Met Leu Glu Val 
            100                 105                 110         


Ala Glu Lys Leu Lys Cys Leu Asp Leu Ser Glu Thr Cys Phe Gln Leu 
        115                 120                 125             


Lys Lys Gln Met Leu Glu Ser Val Leu Leu Glu Leu Gln Asn Phe Ser 
    130                 135                 140                 


Glu Ser Gln Glu Val Glu Val Ser Ser Gly Ser Gln Val Ser Ala Ala 
145                 150                 155                 160 


Pro Ala Pro Arg Ala Ser Val Ala Thr Asp Gly Pro His Pro Ser Gly 
                165                 170                 175     


Leu Thr Asp Ser Leu Asp Tyr Pro Gly Glu Arg Ala Ser Asn Gly Met 
            180                 185                 190         


Ser Ser Asp Leu Pro Pro Lys Lys Ser Lys Asp Lys Leu Asp Lys Lys 
        195                 200                 205             


Lys Glu Val Val Lys Pro Pro Tyr Pro Lys Ile Arg Arg Ala Ser Gly 
    210                 215                 220                 


Arg Leu Ala Gly Arg Lys Val Phe Val Glu Ile Pro Lys Lys Lys Tyr 
225                 230                 235                 240 


Thr Arg Arg Leu Arg Glu Gln Gln Lys Thr Ala Glu Gly Asp Val Gly 
                245                 250                 255     


Asp Tyr Arg Cys Pro Gln Asp Gln Ser Pro Asp Arg Val Gly Thr Glu 
            260                 265                 270         


Met Glu Gln Val Ser Lys Asn Glu Gly Cys Gln Ala Gly Ala Glu Leu 
        275                 280                 285             


Glu Glu Leu Ser Lys Lys Ala Gly Pro Glu Glu Glu Glu Glu Glu Glu 
    290                 295                 300                 


Glu Glu Asp Glu Glu Gly Glu Lys Lys Lys Ser Asn Phe Lys Cys Ser 
305                 310                 315                 320 


Ile Cys Glu Lys Ala Phe Leu Tyr Glu Lys Ser Phe Leu Lys His Ser 
                325                 330                 335     


Lys His Arg His Gly Val Ala Thr Glu Val Val Tyr Arg Cys Asp Thr 
            340                 345                 350         


Cys Gly Gln Thr Phe Ala Asn Arg Cys Asn Leu Lys Ser His Gln Arg 
        355                 360                 365             


His Val His Ser Ser Glu Arg His Phe Pro Cys Glu Leu Cys Gly Lys 
    370                 375                 380                 


Lys Phe Lys Arg Lys Lys Asp Val Lys Arg His Val Leu Gln Val His 
385                 390                 395                 400 


Glu Gly Gly Gly Glu Arg His Arg Cys Gly Gln Cys Gly Lys Gly Leu 
                405                 410                 415     


Ser Ser Lys Thr Ala Leu Arg Leu His Glu Arg Thr His Thr Gly Asp 
            420                 425                 430         


Arg Pro Tyr Gly Cys Thr Glu Cys Gly Ala Arg Phe Ser Gln Pro Ser 
        435                 440                 445             


Ala Leu Lys Thr His Met Arg 
    450                 455 


<210>  4830
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GZMA__Homo_sapiens__NP_006135

<400>  4830

Met Arg Asn Ser Tyr Arg Phe Leu Ala Ser Ser Leu Ser Val Val Val 
1               5                   10                  15      


Ser Leu Leu Leu Ile Pro Glu Asp Val Cys Glu Lys Ile Ile Gly Gly 
            20                  25                  30          


Asn Glu Val Thr Pro His Ser Arg Pro Tyr Met Val Leu Leu Ser Leu 
        35                  40                  45              


Asp Arg Lys Thr Ile Cys Ala Gly Ala Leu Ile Ala Lys Asp Trp Val 
    50                  55                  60                  


Leu Thr Ala Ala His Cys Asn Leu Asn Lys Arg Ser Gln Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Ser Ile Thr Arg Glu Glu Pro Thr Lys Gln Ile Met Leu 
                85                  90                  95      


Val Lys Lys Glu Phe Pro Tyr Pro Cys Tyr Asp Pro Ala Thr Arg Glu 
            100                 105                 110         


Gly Asp Leu Lys Leu Leu Gln Leu Thr Glu Lys Ala Lys Ile Asn Lys 
        115                 120                 125             


Tyr Val Thr Ile Leu His Leu Pro Lys Lys Gly Asp Asp Val Lys Pro 
    130                 135                 140                 


Gly Thr Met Cys Gln Val Ala Gly Trp Gly Arg Thr His Asn Ser Ala 
145                 150                 155                 160 


Ser Trp Ser Asp Thr Leu Arg Glu Val Asn Ile Thr Ile Ile Asp Arg 
                165                 170                 175     


Lys Val Cys Asn Asp Arg Asn His Tyr Asn Phe Asn Pro Val Ile Gly 
            180                 185                 190         


Met Asn Met Val Cys Ala Gly Ser Leu Arg Gly Gly Arg Asp Ser Cys 
        195                 200                 205             


Asn Gly Asp Ser Gly Ser Pro Leu Leu Cys Glu Gly Val Phe Arg Gly 
    210                 215                 220                 


Val Thr Ser Phe Gly Leu Glu Asn Lys Cys Gly Asp Pro Arg Gly Pro 
225                 230                 235                 240 


Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn Trp Ile Ile Met 
                245                 250                 255     


Thr Ile Lys Gly Ala Val 
            260         


<210>  4831
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GZMB__Homo_sapiens__NP_004122

<400>  4831

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu 
145                 150                 155                 160 


Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp 
                165                 170                 175     


Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro 
            180                 185                 190         


Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly 
    210                 215                 220                 


Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile 
225                 230                 235                 240 


Lys Lys Thr Met Lys Arg Tyr 
                245         


<210>  4832
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GZMH__Homo_sapiens__NP_001257710

<400>  4832

Met Gln Pro Phe Leu Leu Leu Leu Ala Phe Leu Leu Thr Pro Gly Ala 
1               5                   10                  15      


Gly Thr Glu Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Phe Val Gln Phe Leu Gln Glu Lys Ser Arg Lys Arg 
        35                  40                  45              


Cys Gly Gly Ile Leu Val Arg Lys Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Gln Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Arg Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Asp Val Ala Gln Gly 
        115                 120                 125             


Ile Leu Ser Tyr Gly Asn Lys Lys Gly Thr Pro Pro Gly Val Tyr Ile 
    130                 135                 140                 


Lys Val Ser His Phe Leu Pro Trp Ile Lys Arg Thr Met Lys Arg Leu 
145                 150                 155                 160 


<210>  4833
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GZMK__Homo_sapiens__NP_002095

<400>  4833

Met Thr Lys Phe Ser Ser Phe Ser Leu Phe Phe Leu Ile Val Gly Ala 
1               5                   10                  15      


Tyr Met Thr His Val Cys Phe Asn Met Glu Ile Ile Gly Gly Lys Glu 
            20                  25                  30          


Val Ser Pro His Ser Arg Pro Phe Met Ala Ser Ile Gln Tyr Gly Gly 
        35                  40                  45              


His His Val Cys Gly Gly Val Leu Ile Asp Pro Gln Trp Val Leu Thr 
    50                  55                  60                  


Ala Ala His Cys Gln Tyr Arg Phe Thr Lys Gly Gln Ser Pro Thr Val 
65                  70                  75                  80  


Val Leu Gly Ala His Ser Leu Ser Lys Asn Glu Ala Ser Lys Gln Thr 
                85                  90                  95      


Leu Glu Ile Lys Lys Phe Ile Pro Phe Ser Arg Val Thr Ser Asp Pro 
            100                 105                 110         


Gln Ser Asn Asp Ile Met Leu Val Lys Leu Gln Thr Ala Ala Lys Leu 
        115                 120                 125             


Asn Lys His Val Lys Met Leu His Ile Arg Ser Lys Thr Ser Leu Arg 
    130                 135                 140                 


Ser Gly Thr Lys Cys Lys Val Thr Gly Trp Gly Ala Thr Asp Pro Asp 
145                 150                 155                 160 


Ser Leu Arg Pro Ser Asp Thr Leu Arg Glu Val Thr Val Thr Val Leu 
                165                 170                 175     


Ser Arg Lys Leu Cys Asn Ser Gln Ser Tyr Tyr Asn Gly Asp Pro Phe 
            180                 185                 190         


Ile Thr Lys Asp Met Val Cys Ala Gly Asp Ala Lys Gly Gln Lys Asp 
        195                 200                 205             


Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Cys Lys Gly Val Phe 
    210                 215                 220                 


His Ala Ile Val Ser Gly Gly His Glu Cys Gly Val Ala Thr Lys Pro 
225                 230                 235                 240 


Gly Ile Tyr Thr Leu Leu Thr Lys Lys Tyr Gln Thr Trp Ile Lys Ser 
                245                 250                 255     


Asn Leu Val Pro Pro His Thr Asn 
            260                 


<210>  4834
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GZMM__Homo_sapiens__NP_005308

<400>  4834

Met Glu Ala Cys Val Ser Ser Leu Leu Val Leu Ala Leu Gly Ala Leu 
1               5                   10                  15      


Ser Val Gly Ser Ser Phe Gly Thr Gln Ile Ile Gly Gly Arg Glu Val 
            20                  25                  30          


Ile Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Arg Asn Gly Ser 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val His Pro Lys Trp Val Leu Thr Ala 
    50                  55                  60                  


Ala His Cys Leu Ala Gln Arg Met Ala Gln Leu Arg Leu Val Leu Gly 
65                  70                  75                  80  


Leu His Thr Leu Asp Ser Pro Gly Leu Thr Phe His Ile Lys Ala Ala 
                85                  90                  95      


Ile Gln His Pro Arg Tyr Lys Pro Val Pro Ala Leu Glu Asn Asp Leu 
            100                 105                 110         


Ala Leu Leu Gln Leu Asp Gly Lys Val Lys Pro Ser Arg Thr Ile Arg 
        115                 120                 125             


Pro Leu Ala Leu Pro Ser Lys Arg Gln Val Val Ala Ala Gly Thr Arg 
    130                 135                 140                 


Cys Ser Met Ala Gly Trp Gly Leu Thr His Gln Gly Gly Arg Leu Ser 
145                 150                 155                 160 


Arg Val Leu Arg Glu Leu Asp Leu Gln Val Leu Asp Thr Arg Met Cys 
                165                 170                 175     


Asn Asn Ser Arg Phe Trp Asn Gly Ser Leu Ser Pro Ser Met Val Cys 
            180                 185                 190         


Leu Ala Ala Asp Ser Lys Asp Gln Ala Pro Cys Lys Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Val Cys Gly Lys Gly Arg Val Leu Ala Gly Val Leu Ser 
    210                 215                 220                 


Phe Ser Ser Arg Val Cys Thr Asp Ile Phe Lys Pro Pro Val Ala Thr 
225                 230                 235                 240 


Ala Val Ala Pro Tyr Val Ser Trp Ile Arg Lys Val Thr Gly Arg Ser 
                245                 250                 255     


Ala 
    


<210>  4835
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1F0__Homo_sapiens__NP_005309

<400>  4835

Met Thr Glu Asn Ser Thr Ser Ala Pro Ala Ala Lys Pro Lys Arg Ala 
1               5                   10                  15      


Lys Ala Ser Lys Lys Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile 
            20                  25                  30          


Val Ala Ala Ile Gln Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln 
        35                  40                  45              


Ser Ile Gln Lys Tyr Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala 
    50                  55                  60                  


Asp Ser Gln Ile Lys Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val 
65                  70                  75                  80  


Leu Lys Gln Thr Lys Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala 
                85                  90                  95      


Lys Ser Asp Glu Pro Lys Lys Ser Val Ala Phe Lys Lys Thr Lys Lys 
            100                 105                 110         


Glu Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys Lys 
        115                 120                 125             


Ala Ala Ser Lys Ala Pro Thr Lys Lys Pro Lys Ala Thr Pro Val Lys 
    130                 135                 140                 


Lys Ala Lys Lys Lys Leu Ala Ala Thr Pro Lys Lys Ala Lys Lys Pro 
145                 150                 155                 160 


Lys Thr Val Lys Ala Lys Pro Val Lys Ala Ser Lys Pro Lys Lys Ala 
                165                 170                 175     


Lys Pro Val Lys Pro Lys Ala Lys Ser Ser Ala Lys Arg Ala Gly Lys 
            180                 185                 190         


Lys Lys 
        


<210>  4836
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1FX__Homo_sapiens__NP_006017

<400>  4836

Met Ser Val Glu Leu Glu Glu Ala Leu Pro Val Thr Thr Ala Glu Gly 
1               5                   10                  15      


Met Ala Lys Lys Val Thr Lys Ala Gly Gly Ser Ala Ala Leu Ser Pro 
            20                  25                  30          


Ser Lys Lys Arg Lys Asn Ser Lys Lys Lys Asn Gln Pro Gly Lys Tyr 
        35                  40                  45              


Ser Gln Leu Val Val Glu Thr Ile Arg Arg Leu Gly Glu Arg Asn Gly 
    50                  55                  60                  


Ser Ser Leu Ala Lys Ile Tyr Thr Glu Ala Lys Lys Val Pro Trp Phe 
65                  70                  75                  80  


Asp Gln Gln Asn Gly Arg Thr Tyr Leu Lys Tyr Ser Ile Lys Ala Leu 
                85                  90                  95      


Val Gln Asn Asp Thr Leu Leu Gln Val Lys Gly Thr Gly Ala Asn Gly 
            100                 105                 110         


Ser Phe Lys Leu Asn Arg Lys Lys Leu Glu Gly Gly Gly Glu Arg Arg 
        115                 120                 125             


Gly Ala Pro Ala Ala Ala Thr Ala Pro Ala Pro Thr Ala His Lys Ala 
    130                 135                 140                 


Lys Lys Ala Ala Pro Gly Ala Ala Gly Ser Arg Arg Ala Asp Lys Lys 
145                 150                 155                 160 


Pro Ala Arg Gly Gln Lys Pro Glu Gln Arg Ser His Lys Lys Gly Ala 
                165                 170                 175     


Gly Ala Lys Lys Asp Lys Gly Gly Lys Ala Lys Lys Thr Ala Ala Ala 
            180                 185                 190         


Gly Gly Lys Lys Val Lys Lys Ala Ala Lys Pro Ser Val Pro Lys Val 
        195                 200                 205             


Pro Lys Gly Arg Lys 
    210             


<210>  4837
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2AFJ__Homo_sapiens__NP_808760

<400>  4837

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Val Arg Ala Lys Ala Lys 
1               5                   10                  15      


Ser Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser Gln Lys Thr Lys Ser 
        115                 120                 125             


Lys 
    


<210>  4838
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2AFX__Homo_sapiens__NP_002096

<400>  4838

Met Ser Gly Arg Gly Lys Thr Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Ser Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly His Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Gly Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Ser Ala Thr Val Gly Pro Lys 
        115                 120                 125             


Ala Pro Ser Gly Gly Lys Lys Ala Thr Gln Ala Ser Gln Glu Tyr 
    130                 135                 140             


<210>  4839
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2AFY2__Homo_sapiens__NP_061119

<400>  4839

Met Ser Gly Arg Ser Gly Lys Lys Lys Met Ser Lys Leu Ser Arg Ser 
1               5                   10                  15      


Ala Arg Ala Gly Val Ile Phe Pro Val Gly Arg Leu Met Arg Tyr Leu 
            20                  25                  30          


Lys Lys Gly Thr Phe Lys Tyr Arg Ile Ser Val Gly Ala Pro Val Tyr 
        35                  40                  45              


Met Ala Ala Val Ile Glu Tyr Leu Ala Ala Glu Ile Leu Glu Leu Ala 
    50                  55                  60                  


Gly Asn Ala Ala Arg Asp Asn Lys Lys Ala Arg Ile Ala Pro Arg His 
65                  70                  75                  80  


Ile Leu Leu Ala Val Ala Asn Asp Glu Glu Leu Asn Gln Leu Leu Lys 
                85                  90                  95      


Gly Val Thr Ile Ala Ser Gly Gly Val Leu Pro Arg Ile His Pro Glu 
            100                 105                 110         


Leu Leu Ala Lys Lys Arg Gly Thr Lys Gly Lys Ser Glu Thr Ile Leu 
        115                 120                 125             


Ser Pro Pro Pro Glu Lys Arg Gly Arg Lys Ala Thr Ser Gly Lys Lys 
    130                 135                 140                 


Gly Gly Lys Lys Ser Lys Ala Ala Lys Pro Arg Thr Ser Lys Lys Ser 
145                 150                 155                 160 


Lys Pro Lys Asp Ser Asp Lys Glu Gly Thr Ser Asn Ser Thr Ser Glu 
                165                 170                 175     


Asp Gly Pro Gly Asp Gly Phe Thr Ile Leu Ser Ser Lys Ser Leu Val 
            180                 185                 190         


Leu Gly Gln Lys Leu Ser Leu Thr Gln Ser Asp Ile Ser His Ile Gly 
        195                 200                 205             


Ser Met Arg Val Glu Gly Ile Val His Pro Thr Thr Ala Glu Ile Asp 
    210                 215                 220                 


Leu Lys Glu Asp Ile Gly Lys Ala Leu Glu Lys Ala Gly Gly Lys Glu 
225                 230                 235                 240 


Phe Leu Glu Thr Val Lys Glu Leu Arg Lys Ser Gln Gly Pro Leu Glu 
                245                 250                 255     


Val Ala Glu Ala Ala Val Ser Gln Ser Ser Gly Leu Ala Ala Lys Phe 
            260                 265                 270         


Val Ile His Cys His Ile Pro Gln Trp Gly Ser Asp Lys Cys Glu Glu 
        275                 280                 285             


Gln Leu Glu Glu Thr Ile Lys Asn Cys Leu Ser Ala Ala Glu Asp Lys 
    290                 295                 300                 


Lys Leu Lys Ser Val Ala Phe Pro Pro Phe Pro Ser Gly Arg Asn Cys 
305                 310                 315                 320 


Phe Pro Lys Gln Thr Ala Ala Gln Val Thr Leu Lys Ala Ile Ser Ala 
                325                 330                 335     


His Phe Asp Asp Ser Ser Ala Ser Ser Leu Lys Asn Val Tyr Phe Leu 
            340                 345                 350         


Leu Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln Glu Met Ala Lys 
        355                 360                 365             


Leu Asp Ala Lys 
    370         


<210>  4840
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2AFY__Homo_sapiens__NP_004884

<400>  4840

Met Ser Ser Arg Gly Gly Lys Lys Lys Ser Thr Lys Thr Ser Arg Ser 
1               5                   10                  15      


Ala Lys Ala Gly Val Ile Phe Pro Val Gly Arg Met Leu Arg Tyr Ile 
            20                  25                  30          


Lys Lys Gly His Pro Lys Tyr Arg Ile Gly Val Gly Ala Pro Val Tyr 
        35                  40                  45              


Met Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu Glu Leu Ala 
    50                  55                  60                  


Gly Asn Ala Ala Arg Asp Asn Lys Lys Gly Arg Val Thr Pro Arg His 
65                  70                  75                  80  


Ile Leu Leu Ala Val Ala Asn Asp Glu Glu Leu Asn Gln Leu Leu Lys 
                85                  90                  95      


Gly Val Thr Ile Ala Ser Gly Gly Val Leu Pro Asn Ile His Pro Glu 
            100                 105                 110         


Leu Leu Ala Lys Lys Arg Gly Ser Lys Gly Lys Leu Glu Ala Ile Ile 
        115                 120                 125             


Thr Pro Pro Pro Ala Lys Lys Ala Lys Ser Pro Ser Gln Lys Lys Pro 
    130                 135                 140                 


Val Ser Lys Lys Ala Gly Gly Lys Lys Gly Ala Arg Lys Ser Lys Lys 
145                 150                 155                 160 


Gln Gly Glu Val Ser Lys Ala Ala Ser Ala Asp Ser Thr Thr Glu Gly 
                165                 170                 175     


Thr Pro Ala Asp Gly Phe Thr Val Leu Ser Thr Lys Ser Leu Phe Leu 
            180                 185                 190         


Gly Gln Lys Leu Asn Leu Ile His Ser Glu Ile Ser Asn Leu Ala Gly 
        195                 200                 205             


Phe Glu Val Glu Ala Ile Ile Asn Pro Thr Asn Ala Asp Ile Asp Leu 
    210                 215                 220                 


Lys Asp Asp Leu Gly Asn Thr Leu Glu Lys Lys Gly Gly Lys Glu Phe 
225                 230                 235                 240 


Val Glu Ala Val Leu Glu Leu Arg Lys Lys Asn Gly Pro Leu Glu Val 
                245                 250                 255     


Ala Gly Ala Ala Val Ser Ala Gly His Gly Leu Pro Ala Lys Phe Val 
            260                 265                 270         


Ile His Cys Asn Ser Pro Val Trp Gly Ala Asp Lys Cys Glu Glu Leu 
        275                 280                 285             


Leu Glu Lys Thr Val Lys Asn Cys Leu Ala Leu Ala Asp Asp Lys Lys 
    290                 295                 300                 


Leu Lys Ser Ile Ala Phe Pro Ser Ile Gly Ser Gly Arg Asn Gly Phe 
305                 310                 315                 320 


Pro Lys Gln Thr Ala Ala Gln Leu Ile Leu Lys Ala Ile Ser Ser Tyr 
                325                 330                 335     


Phe Val Ser Thr Met Ser Ser Ser Ile Lys Thr Val Tyr Phe Val Leu 
            340                 345                 350         


Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln Glu Met Ala Lys Leu 
        355                 360                 365             


Asp Ala Asn 
    370     


<210>  4841
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2AFZ__Homo_sapiens__NP_002097

<400>  4841

Met Ala Gly Gly Lys Ala Gly Lys Asp Ser Gly Lys Ala Lys Thr Lys 
1               5                   10                  15      


Ala Val Ser Arg Ser Gln Arg Ala Gly Leu Gln Phe Pro Val Gly Arg 
            20                  25                  30          


Ile His Arg His Leu Lys Ser Arg Thr Thr Ser His Gly Arg Val Gly 
        35                  40                  45              


Ala Thr Ala Ala Val Tyr Ser Ala Ala Ile Leu Glu Tyr Leu Thr Ala 
    50                  55                  60                  


Glu Val Leu Glu Leu Ala Gly Asn Ala Ser Lys Asp Leu Lys Val Lys 
65                  70                  75                  80  


Arg Ile Thr Pro Arg His Leu Gln Leu Ala Ile Arg Gly Asp Glu Glu 
                85                  90                  95      


Leu Asp Ser Leu Ile Lys Ala Thr Ile Ala Gly Gly Gly Val Ile Pro 
            100                 105                 110         


His Ile His Lys Ser Leu Ile Gly Lys Lys Gly Gln Gln Lys Thr Val 
        115                 120                 125             


<210>  4842
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2BFWT__Homo_sapiens__NP_001002916

<400>  4842

Met Leu Arg Thr Glu Val Pro Arg Leu Pro Arg Ser Thr Thr Ala Ile 
1               5                   10                  15      


Val Trp Ser Cys His Leu Met Ala Thr Ala Ser Ala Met Ala Gly Pro 
            20                  25                  30          


Ser Ser Glu Thr Thr Ser Glu Glu Gln Leu Ile Thr Gln Glu Pro Lys 
        35                  40                  45              


Glu Ala Asn Ser Thr Thr Ser Gln Lys Gln Ser Lys Gln Arg Lys Arg 
    50                  55                  60                  


Gly Arg His Gly Pro Arg Arg Cys His Ser Asn Cys Arg Gly Asp Ser 
65                  70                  75                  80  


Phe Ala Thr Tyr Phe Arg Arg Val Leu Lys Gln Val His Gln Gly Leu 
                85                  90                  95      


Ser Leu Ser Arg Glu Ala Val Ser Val Met Asp Ser Leu Val His Asp 
            100                 105                 110         


Ile Leu Asp Arg Ile Ala Thr Glu Ala Gly His Leu Ala Arg Ser Thr 
        115                 120                 125             


Lys Arg Gln Thr Ile Thr Ala Trp Glu Thr Arg Met Ala Val Arg Leu 
    130                 135                 140                 


Leu Leu Pro Gly Gln Met Gly Lys Leu Ala Glu Ser Glu Gly Thr Lys 
145                 150                 155                 160 


Ala Val Leu Arg Thr Ser Leu Tyr Ala Ile Gln Gln Gln Arg Lys 
                165                 170                 175 


<210>  4843
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3F3B__Homo_sapiens__NP_005315

<400>  4843

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  4844
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAAO__Homo_sapiens__NP_036337

<400>  4844

Met Glu Arg Arg Leu Gly Val Arg Ala Trp Val Lys Glu Asn Arg Gly 
1               5                   10                  15      


Ser Phe Gln Pro Pro Val Cys Asn Lys Leu Met His Gln Glu Gln Leu 
            20                  25                  30          


Lys Val Met Phe Ile Gly Gly Pro Asn Thr Arg Lys Asp Tyr His Ile 
        35                  40                  45              


Glu Glu Gly Glu Glu Val Phe Tyr Gln Leu Glu Gly Asp Met Val Leu 
    50                  55                  60                  


Arg Val Leu Glu Gln Gly Lys His Arg Asp Val Val Ile Arg Gln Gly 
65                  70                  75                  80  


Glu Ile Phe Leu Leu Pro Ala Arg Val Pro His Ser Pro Gln Arg Phe 
                85                  90                  95      


Ala Asn Thr Val Gly Leu Val Val Glu Arg Arg Arg Leu Glu Thr Glu 
            100                 105                 110         


Leu Asp Gly Leu Arg Tyr Tyr Val Gly Asp Thr Met Asp Val Leu Phe 
        115                 120                 125             


Glu Lys Trp Phe Tyr Cys Lys Asp Leu Gly Thr Gln Leu Ala Pro Ile 
    130                 135                 140                 


Ile Gln Glu Phe Phe Ser Ser Glu Gln Tyr Arg Thr Gly Lys Pro Ile 
145                 150                 155                 160 


Pro Asp Gln Leu Leu Lys Glu Pro Pro Phe Pro Leu Ser Thr Arg Ser 
                165                 170                 175     


Ile Met Glu Pro Met Ser Leu Asp Ala Trp Leu Asp Ser His His Arg 
            180                 185                 190         


Glu Leu Gln Ala Gly Thr Pro Leu Ser Leu Phe Gly Asp Thr Tyr Glu 
        195                 200                 205             


Thr Gln Val Ile Ala Tyr Gly Gln Gly Ser Ser Glu Gly Leu Arg Gln 
    210                 215                 220                 


Asn Val Asp Val Trp Leu Trp Gln Leu Glu Gly Ser Ser Val Val Thr 
225                 230                 235                 240 


Met Gly Gly Arg Arg Leu Ser Leu Ala Pro Asp Asp Ser Leu Leu Val 
                245                 250                 255     


Leu Ala Gly Thr Ser Tyr Ala Trp Glu Arg Thr Gln Gly Ser Val Ala 
            260                 265                 270         


Leu Ser Val Thr Gln Asp Pro Ala Cys Lys Lys Pro Leu Gly 
        275                 280                 285     


<210>  4845
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HABP2__Homo_sapiens__NP_001171131

<400>  4845

Met Ser Leu Leu Glu Ser Leu Asp Pro Asp Trp Thr Pro Asp Gln Tyr 
1               5                   10                  15      


Asp Tyr Ser Tyr Glu Asp Tyr Asn Gln Glu Glu Asn Thr Ser Ser Thr 
            20                  25                  30          


Leu Thr His Ala Glu Asn Pro Asp Trp Tyr Tyr Thr Glu Asp Gln Ala 
        35                  40                  45              


Asp Pro Cys Gln Pro Asn Pro Cys Glu His Gly Gly Asp Cys Leu Val 
    50                  55                  60                  


His Gly Ser Thr Phe Thr Cys Ser Cys Leu Ala Pro Phe Ser Gly Asn 
65                  70                  75                  80  


Lys Cys Gln Lys Val Gln Asn Thr Cys Lys Asp Asn Pro Cys Gly Arg 
                85                  90                  95      


Gly Gln Cys Leu Ile Thr Gln Ser Pro Pro Tyr Tyr Arg Cys Val Cys 
            100                 105                 110         


Lys His Pro Tyr Thr Gly Pro Ser Cys Ser Gln Val Val Pro Val Cys 
        115                 120                 125             


Arg Pro Asn Pro Cys Gln Asn Gly Ala Thr Cys Ser Arg His Lys Arg 
    130                 135                 140                 


Arg Ser Lys Phe Thr Cys Ala Cys Pro Asp Gln Phe Lys Gly Lys Phe 
145                 150                 155                 160 


Cys Glu Ile Gly Ser Asp Asp Cys Tyr Val Gly Asp Gly Tyr Ser Tyr 
                165                 170                 175     


Arg Gly Lys Met Asn Arg Thr Val Asn Gln His Ala Cys Leu Tyr Trp 
            180                 185                 190         


Asn Ser His Leu Leu Leu Gln Glu Asn Tyr Asn Met Phe Met Glu Asp 
        195                 200                 205             


Ala Glu Thr His Gly Ile Gly Glu His Asn Phe Cys Arg Asn Pro Asp 
    210                 215                 220                 


Ala Asp Glu Lys Pro Trp Cys Phe Ile Lys Val Thr Asn Asp Lys Val 
225                 230                 235                 240 


Lys Trp Glu Tyr Cys Asp Val Ser Ala Cys Ser Ala Gln Asp Val Ala 
                245                 250                 255     


Tyr Pro Glu Glu Ser Pro Thr Glu Pro Ser Thr Lys Leu Pro Gly Phe 
            260                 265                 270         


Asp Ser Cys Gly Lys Thr Glu Ile Ala Glu Arg Lys Ile Lys Arg Ile 
        275                 280                 285             


Tyr Gly Gly Phe Lys Ser Thr Ala Gly Lys His Pro Trp Gln Ala Ser 
    290                 295                 300                 


Leu Gln Ser Ser Leu Pro Leu Thr Ile Ser Met Pro Gln Gly His Phe 
305                 310                 315                 320 


Cys Gly Gly Ala Leu Ile His Pro Cys Trp Val Leu Thr Ala Ala His 
                325                 330                 335     


Cys Thr Asp Ile Lys Thr Arg His Leu Lys Val Val Leu Gly Asp Gln 
            340                 345                 350         


Asp Leu Lys Lys Glu Glu Phe His Glu Gln Ser Phe Arg Val Glu Lys 
        355                 360                 365             


Ile Phe Lys Tyr Ser His Tyr Asn Glu Arg Asp Glu Ile Pro His Asn 
    370                 375                 380                 


Asp Ile Ala Leu Leu Lys Leu Lys Pro Val Asp Gly His Cys Ala Leu 
385                 390                 395                 400 


Glu Ser Lys Tyr Val Lys Thr Val Cys Leu Pro Asp Gly Ser Phe Pro 
                405                 410                 415     


Ser Gly Ser Glu Cys His Ile Ser Gly Trp Gly Val Thr Glu Thr Gly 
            420                 425                 430         


Lys Gly Ser Arg Gln Leu Leu Asp Ala Lys Val Lys Leu Ile Ala Asn 
        435                 440                 445             


Thr Leu Cys Asn Ser Arg Gln Leu Tyr Asp His Met Ile Asp Asp Ser 
    450                 455                 460                 


Met Ile Cys Ala Gly Asn Leu Gln Lys Pro Gly Gln Asp Thr Cys Gln 
465                 470                 475                 480 


Gly Asp Ser Gly Gly Pro Leu Thr Cys Glu Lys Asp Gly Thr Tyr Tyr 
                485                 490                 495     


Val Tyr Gly Ile Val Ser Trp Gly Leu Glu Cys Gly Lys Arg Pro Gly 
            500                 505                 510         


Val Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Ala Thr Ile 
        515                 520                 525             


Lys Ser Glu Ser Gly Phe 
    530                 


<210>  4846
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HABP4__Homo_sapiens__NP_055097

<400>  4846

Met Lys Gly Ala Leu Gly Ser Pro Val Ala Ala Ala Gly Ala Ala Met 
1               5                   10                  15      


Gln Glu Ser Phe Gly Cys Val Val Ala Asn Arg Phe His Gln Leu Leu 
            20                  25                  30          


Asp Asp Glu Ser Asp Pro Phe Asp Ile Leu Arg Glu Ala Glu Arg Arg 
        35                  40                  45              


Arg Gln Gln Gln Leu Gln Arg Lys Arg Arg Asp Glu Ala Ala Ala Ala 
    50                  55                  60                  


Ala Gly Ala Gly Pro Arg Gly Gly Arg Ser Pro Ala Gly Ala Ser Gly 
65                  70                  75                  80  


His Arg Ala Gly Ala Gly Gly Arg Arg Glu Ser Gln Lys Glu Arg Lys 
                85                  90                  95      


Ser Leu Pro Ala Pro Val Ala Gln Arg Pro Asp Ser Pro Gly Gly Gly 
            100                 105                 110         


Leu Gln Ala Pro Gly Gln Lys Arg Thr Pro Arg Arg Gly Glu Gln Gln 
        115                 120                 125             


Gly Trp Asn Asp Ser Arg Gly Pro Glu Gly Met Leu Glu Arg Ala Glu 
    130                 135                 140                 


Arg Arg Ser Tyr Arg Glu Tyr Arg Pro Tyr Glu Thr Glu Arg Gln Ala 
145                 150                 155                 160 


Asp Phe Thr Ala Glu Lys Phe Pro Asp Glu Lys Pro Gly Asp Arg Phe 
                165                 170                 175     


Asp Arg Asp Arg Pro Leu Arg Gly Arg Gly Gly Pro Arg Gly Gly Met 
            180                 185                 190         


Arg Gly Arg Gly Arg Gly Gly Pro Gly Asn Arg Val Phe Asp Ala Phe 
        195                 200                 205             


Asp Gln Arg Gly Lys Arg Glu Phe Glu Arg Tyr Gly Gly Asn Asp Lys 
    210                 215                 220                 


Ile Ala Val Arg Thr Glu Asp Asn Met Gly Gly Cys Gly Val Arg Thr 
225                 230                 235                 240 


Trp Gly Ser Gly Lys Asp Thr Ser Asp Val Glu Pro Thr Ala Pro Met 
                245                 250                 255     


Glu Glu Pro Thr Val Val Glu Glu Ser Gln Gly Thr Pro Glu Glu Glu 
            260                 265                 270         


Ser Pro Ala Lys Val Pro Glu Leu Glu Val Glu Glu Glu Thr Gln Val 
        275                 280                 285             


Gln Glu Met Thr Leu Asp Glu Trp Lys Asn Leu Gln Glu Gln Thr Arg 
    290                 295                 300                 


Pro Lys Pro Glu Phe Asn Ile Arg Lys Pro Glu Ser Thr Val Pro Ser 
305                 310                 315                 320 


Lys Ala Val Val Ile His Lys Ser Lys Tyr Arg Asp Asp Met Val Lys 
                325                 330                 335     


Asp Asp Tyr Glu Asp Asp Ser His Val Phe Arg Lys Pro Ala Asn Asp 
            340                 345                 350         


Ile Thr Ser Gln Leu Glu Ile Asn Phe Gly Asn Leu Pro Arg Pro Gly 
        355                 360                 365             


Arg Gly Ala Arg Gly Gly Thr Arg Gly Gly Arg Gly Arg Ile Arg Arg 
    370                 375                 380                 


Ala Glu Asn Tyr Gly Pro Arg Ala Glu Val Val Met Gln Asp Val Ala 
385                 390                 395                 400 


Pro Asn Pro Asp Asp Pro Glu Asp Phe Pro Ala Leu Ser 
                405                 410             


<210>  4847
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HACD1__Homo_sapiens__NP_055056

<400>  4847

Met Gly Arg Leu Thr Glu Ala Ala Ala Ala Gly Ser Gly Ser Arg Ala 
1               5                   10                  15      


Ala Gly Trp Ala Gly Ser Pro Pro Thr Leu Leu Pro Leu Ser Pro Thr 
            20                  25                  30          


Ser Pro Arg Cys Ala Ala Thr Met Ala Ser Ser Asp Glu Asp Gly Thr 
        35                  40                  45              


Asn Gly Gly Ala Ser Glu Ala Gly Glu Asp Arg Glu Ala Pro Gly Glu 
    50                  55                  60                  


Arg Arg Arg Leu Gly Val Leu Ala Thr Ala Trp Leu Thr Phe Tyr Asp 
65                  70                  75                  80  


Ile Ala Met Thr Ala Gly Trp Leu Val Leu Ala Ile Ala Met Val Arg 
                85                  90                  95      


Phe Tyr Met Glu Lys Gly Thr His Arg Gly Leu Tyr Lys Ser Ile Gln 
            100                 105                 110         


Lys Thr Leu Lys Phe Phe Gln Thr Phe Ala Leu Leu Glu Ile Val His 
        115                 120                 125             


Cys Leu Ile Gly Ile Val Pro Thr Ser Val Ile Val Thr Gly Val Gln 
    130                 135                 140                 


Val Ser Ser Arg Ile Phe Met Val Trp Leu Ile Thr His Ser Ile Lys 
145                 150                 155                 160 


Pro Ile Gln Asn Glu Glu Ser Val Val Leu Phe Leu Val Ala Trp Thr 
                165                 170                 175     


Val Thr Glu Ile Thr Arg Tyr Ser Phe Tyr Thr Phe Ser Leu Leu Asp 
            180                 185                 190         


His Leu Pro Tyr Phe Ile Lys Trp Ala Arg Tyr Asn Phe Phe Ile Ile 
        195                 200                 205             


Leu Tyr Pro Val Gly Val Ala Gly Glu Leu Leu Thr Ile Tyr Ala Ala 
    210                 215                 220                 


Leu Pro His Val Lys Lys Thr Gly Met Phe Ser Ile Arg Leu Pro Asn 
225                 230                 235                 240 


Lys Tyr Asn Val Ser Phe Asp Tyr Tyr Tyr Phe Leu Leu Ile Thr Met 
                245                 250                 255     


Ala Ser Tyr Ile Pro Leu Phe Pro Gln Leu Tyr Phe His Met Leu Arg 
            260                 265                 270         


Gln Arg Arg Lys Val Leu His Gly Glu Val Ile Val Glu Lys Asp Asp 
        275                 280                 285             


<210>  4848
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HACD2__Homo_sapiens__NP_940684

<400>  4848

Met Ala Ala Val Ala Ala Thr Ala Ala Ala Lys Gly Asn Gly Gly Gly 
1               5                   10                  15      


Gly Gly Arg Ala Gly Ala Gly Asp Ala Ser Gly Thr Arg Lys Lys Lys 
            20                  25                  30          


Gly Pro Gly Pro Leu Ala Thr Ala Tyr Leu Val Ile Tyr Asn Val Val 
        35                  40                  45              


Met Thr Ala Gly Trp Leu Val Ile Ala Val Gly Leu Val Arg Ala Tyr 
    50                  55                  60                  


Leu Ala Lys Gly Ser Tyr His Ser Leu Tyr Tyr Ser Ile Glu Lys Pro 
65                  70                  75                  80  


Leu Lys Phe Phe Gln Thr Gly Ala Leu Leu Glu Ile Leu His Cys Ala 
                85                  90                  95      


Ile Gly Ile Val Pro Ser Ser Val Val Leu Thr Ser Phe Gln Val Met 
            100                 105                 110         


Ser Arg Val Phe Leu Ile Trp Ala Val Thr His Ser Val Lys Glu Val 
        115                 120                 125             


Gln Ser Glu Asp Ser Val Leu Leu Phe Val Ile Ala Trp Thr Ile Thr 
    130                 135                 140                 


Glu Ile Ile Arg Tyr Ser Phe Tyr Thr Phe Ser Leu Leu Asn His Leu 
145                 150                 155                 160 


Pro Tyr Leu Ile Lys Trp Ala Arg Tyr Thr Leu Phe Ile Val Leu Tyr 
                165                 170                 175     


Pro Met Gly Val Ser Gly Glu Leu Leu Thr Ile Tyr Ala Ala Leu Pro 
            180                 185                 190         


Phe Val Arg Gln Ala Gly Leu Tyr Ser Ile Ser Leu Pro Asn Lys Tyr 
        195                 200                 205             


Asn Phe Ser Phe Asp Tyr Tyr Ala Phe Leu Ile Leu Ile Met Ile Ser 
    210                 215                 220                 


Tyr Ile Pro Ile Phe Pro Gln Leu Tyr Phe His Met Ile His Gln Arg 
225                 230                 235                 240 


Arg Lys Ile Leu Ser His Thr Glu Glu His Lys Lys Phe Glu 
                245                 250                 


<210>  4849
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HACD4__Homo_sapiens__NP_001010915

<400>  4849

Met Gly Pro Leu Ala Leu Pro Ala Trp Leu Gln Pro Arg Tyr Arg Lys 
1               5                   10                  15      


Asn Ala Tyr Leu Phe Ile Tyr Tyr Leu Ile Gln Phe Cys Gly His Ser 
            20                  25                  30          


Trp Ile Phe Thr Asn Met Thr Val Arg Phe Phe Ser Phe Gly Lys Asp 
        35                  40                  45              


Ser Met Val Asp Thr Phe Tyr Ala Ile Gly Leu Val Met Arg Leu Cys 
    50                  55                  60                  


Gln Ser Val Ser Leu Leu Glu Leu Leu His Ile Tyr Val Gly Ile Glu 
65                  70                  75                  80  


Ser Asn His Leu Leu Pro Arg Phe Leu Gln Leu Thr Glu Arg Ile Ile 
                85                  90                  95      


Ile Leu Phe Val Val Ile Thr Ser Gln Glu Glu Val Gln Glu Lys Tyr 
            100                 105                 110         


Val Val Cys Val Leu Phe Val Phe Trp Asn Leu Leu Asp Met Val Arg 
        115                 120                 125             


Tyr Thr Tyr Ser Met Leu Ser Val Ile Gly Ile Ser Tyr Ala Val Leu 
    130                 135                 140                 


Thr Trp Leu Ser Gln Thr Leu Trp Met Pro Ile Tyr Pro Leu Cys Val 
145                 150                 155                 160 


Leu Ala Glu Ala Phe Ala Ile Tyr Gln Ser Leu Pro Tyr Phe Glu Ser 
                165                 170                 175     


Phe Gly Thr Tyr Ser Thr Lys Leu Pro Phe Asp Leu Ser Ile Tyr Phe 
            180                 185                 190         


Pro Tyr Val Leu Lys Ile Tyr Leu Met Met Leu Phe Ile Gly Met Tyr 
        195                 200                 205             


Phe Thr Tyr Ser His Leu Tyr Ser Glu Arg Arg Asp Ile Leu Gly Ile 
    210                 215                 220                 


Phe Pro Ile Lys Lys Lys Lys Met 
225                 230         


<210>  4850
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HACE1__Homo_sapiens__NP_065822

<400>  4850

Met Glu Arg Ala Met Glu Gln Leu Asn Arg Leu Thr Arg Ser Leu Arg 
1               5                   10                  15      


Arg Ala Arg Thr Val Glu Leu Pro Glu Asp Asn Glu Thr Ala Val Tyr 
            20                  25                  30          


Thr Leu Met Pro Met Val Met Ala Asp Gln His Arg Ser Val Ser Glu 
        35                  40                  45              


Leu Leu Ser Asn Ser Lys Phe Asp Val Asn Tyr Ala Phe Gly Arg Val 
    50                  55                  60                  


Lys Arg Ser Leu Leu His Ile Ala Ala Asn Cys Gly Ser Val Glu Cys 
65                  70                  75                  80  


Leu Val Leu Leu Leu Lys Lys Gly Ala Asn Pro Asn Tyr Gln Asp Ile 
                85                  90                  95      


Ser Gly Cys Thr Pro Leu His Leu Ala Ala Arg Asn Gly Gln Lys Lys 
            100                 105                 110         


Cys Met Ser Lys Leu Leu Glu Tyr Ser Ala Asp Val Asn Ile Cys Asn 
        115                 120                 125             


Asn Glu Gly Leu Thr Ala Ile His Trp Leu Ala Val Asn Gly Arg Thr 
    130                 135                 140                 


Glu Leu Leu His Asp Leu Val Gln His Val Ser Asp Val Asp Val Glu 
145                 150                 155                 160 


Asp Ala Met Gly Gln Thr Ala Leu His Val Ala Cys Gln Asn Gly His 
                165                 170                 175     


Lys Thr Thr Val Gln Cys Leu Leu Asp Ser Gly Ala Asp Ile Asn Arg 
            180                 185                 190         


Pro Asn Val Ser Gly Ala Thr Pro Leu Tyr Phe Ala Cys Ser His Gly 
        195                 200                 205             


Gln Arg Asp Thr Ala Gln Ile Leu Leu Leu Arg Gly Ala Lys Tyr Leu 
    210                 215                 220                 


Pro Asp Lys Asn Gly Val Thr Pro Leu Asp Leu Cys Val Gln Gly Gly 
225                 230                 235                 240 


Tyr Gly Glu Thr Cys Glu Val Leu Ile Gln Tyr His Pro Arg Leu Phe 
                245                 250                 255     


Gln Thr Ile Ile Gln Met Thr Gln Asn Glu Asp Leu Arg Glu Asn Met 
            260                 265                 270         


Leu Arg Gln Val Leu Glu His Leu Ser Gln Gln Ser Glu Ser Gln Tyr 
        275                 280                 285             


Leu Lys Ile Leu Thr Ser Leu Ala Glu Val Ala Thr Thr Asn Gly His 
    290                 295                 300                 


Lys Leu Leu Ser Leu Ser Ser Asn Tyr Asp Ala Gln Met Lys Ser Leu 
305                 310                 315                 320 


Leu Arg Ile Val Arg Met Phe Cys His Val Phe Arg Ile Gly Pro Ser 
                325                 330                 335     


Ser Pro Ser Asn Gly Ile Asp Met Gly Tyr Asn Gly Asn Lys Thr Pro 
            340                 345                 350         


Arg Ser Gln Val Phe Lys Pro Leu Glu Leu Leu Trp His Ser Leu Asp 
        355                 360                 365             


Glu Trp Leu Val Leu Ile Ala Thr Glu Leu Met Lys Asn Lys Arg Asp 
    370                 375                 380                 


Ser Thr Glu Ile Thr Ser Ile Leu Leu Lys Gln Lys Gly Gln Asp Gln 
385                 390                 395                 400 


Asp Ala Ala Ser Ile Pro Pro Phe Glu Pro Pro Gly Pro Gly Ser Tyr 
                405                 410                 415     


Glu Asn Leu Ser Thr Gly Thr Arg Glu Ser Lys Pro Asp Ala Leu Ala 
            420                 425                 430         


Gly Arg Gln Glu Ala Ser Ala Asp Cys Gln Asp Val Ile Ser Met Thr 
        435                 440                 445             


Ala Asn Arg Leu Ser Ala Val Ile Gln Ala Phe Tyr Met Cys Cys Ser 
    450                 455                 460                 


Cys Gln Met Pro Pro Gly Met Thr Ser Pro Arg Phe Ile Glu Phe Val 
465                 470                 475                 480 


Cys Lys His Asp Glu Val Leu Lys Cys Phe Val Asn Arg Asn Pro Lys 
                485                 490                 495     


Ile Ile Phe Asp His Phe His Phe Leu Leu Glu Cys Pro Glu Leu Met 
            500                 505                 510         


Ser Arg Phe Met His Ile Ile Lys Ala Gln Pro Phe Lys Asp Arg Cys 
        515                 520                 525             


Glu Trp Phe Tyr Glu His Leu His Ser Gly Gln Pro Asp Ser Asp Met 
    530                 535                 540                 


Val His Arg Pro Val Asn Glu Asn Asp Ile Leu Leu Val His Arg Asp 
545                 550                 555                 560 


Ser Ile Phe Arg Ser Ser Cys Glu Val Val Ser Lys Ala Asn Cys Ala 
                565                 570                 575     


Lys Leu Lys Gln Gly Ile Ala Val Arg Phe His Gly Glu Glu Gly Met 
            580                 585                 590         


Gly Gln Gly Val Val Arg Glu Trp Phe Asp Ile Leu Ser Asn Glu Ile 
        595                 600                 605             


Val Asn Pro Asp Tyr Ala Leu Phe Thr Gln Ser Ala Asp Gly Thr Thr 
    610                 615                 620                 


Phe Gln Pro Asn Ser Asn Ser Tyr Val Asn Pro Asp His Leu Asn Tyr 
625                 630                 635                 640 


Phe Arg Phe Ala Gly Gln Ile Leu Gly Leu Ala Leu Asn His Arg Gln 
                645                 650                 655     


Leu Val Asn Ile Tyr Phe Thr Arg Ser Phe Tyr Lys His Ile Leu Gly 
            660                 665                 670         


Ile Pro Val Asn Tyr Gln Asp Val Ala Ser Ile Asp Pro Glu Tyr Ala 
        675                 680                 685             


Lys Asn Leu Gln Trp Ile Leu Asp Asn Asp Ile Ser Asp Leu Gly Leu 
    690                 695                 700                 


Glu Leu Thr Phe Ser Val Glu Thr Asp Val Phe Gly Ala Met Glu Glu 
705                 710                 715                 720 


Val Pro Leu Lys Pro Gly Gly Gly Ser Ile Leu Val Thr Gln Asn Asn 
                725                 730                 735     


Lys Ala Glu Tyr Val Gln Leu Val Thr Glu Leu Arg Met Thr Arg Ala 
            740                 745                 750         


Ile Gln Pro Gln Ile Asn Ala Phe Leu Gln Gly Phe His Met Phe Ile 
        755                 760                 765             


Pro Pro Ser Leu Ile Gln Leu Phe Asp Glu Tyr Glu Leu Glu Leu Leu 
    770                 775                 780                 


Leu Ser Gly Met Pro Glu Ile Asp Val Ser Asp Trp Ile Lys Asn Thr 
785                 790                 795                 800 


Glu Tyr Thr Ser Gly Tyr Glu Arg Glu Asp Pro Val Ile Gln Trp Phe 
                805                 810                 815     


Trp Glu Val Val Glu Asp Ile Thr Gln Glu Glu Arg Val Leu Leu Leu 
            820                 825                 830         


Gln Phe Val Thr Gly Ser Ser Arg Val Pro His Gly Gly Phe Ala Asn 
        835                 840                 845             


Ile Met Gly Gly Ser Gly Leu Gln Asn Phe Thr Ile Ala Ala Val Pro 
    850                 855                 860                 


Tyr Thr Pro Asn Leu Leu Pro Thr Ser Ser Thr Cys Ile Asn Met Leu 
865                 870                 875                 880 


Lys Leu Pro Glu Tyr Pro Ser Lys Glu Ile Leu Lys Asp Arg Leu Leu 
                885                 890                 895     


Val Ala Leu His Cys Gly Ser Tyr Gly Tyr Thr Met Ala 
            900                 905                 


<210>  4851
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HACL1__Homo_sapiens__NP_036392

<400>  4851

Met Pro Asp Ser Asn Phe Ala Glu Arg Ser Glu Glu Gln Val Ser Gly 
1               5                   10                  15      


Ala Lys Val Ile Ala Gln Ala Leu Lys Thr Gln Asp Val Glu Tyr Ile 
            20                  25                  30          


Phe Gly Ile Val Gly Ile Pro Val Thr Glu Ile Ala Ile Ala Ala Gln 
        35                  40                  45              


Gln Leu Gly Ile Lys Tyr Ile Gly Met Arg Asn Glu Gln Ala Ala Cys 
    50                  55                  60                  


Tyr Ala Ala Ser Ala Ile Gly Tyr Leu Thr Ser Arg Pro Gly Val Cys 
65                  70                  75                  80  


Leu Val Val Ser Gly Pro Gly Leu Ile His Ala Leu Gly Gly Met Ala 
                85                  90                  95      


Asn Ala Asn Met Asn Cys Trp Pro Leu Leu Val Ile Gly Gly Ser Ser 
            100                 105                 110         


Glu Arg Asn Gln Glu Thr Met Gly Ala Phe Gln Glu Phe Pro Gln Val 
        115                 120                 125             


Glu Ala Cys Arg Leu Tyr Thr Lys Phe Ser Ala Arg Pro Ser Ser Ile 
    130                 135                 140                 


Glu Ala Ile Pro Phe Val Ile Glu Lys Ala Val Arg Ser Ser Ile Tyr 
145                 150                 155                 160 


Gly Arg Pro Gly Ala Cys Tyr Val Asp Ile Pro Ala Asp Phe Val Asn 
                165                 170                 175     


Leu Gln Val Asn Val Asn Ser Ile Lys Tyr Met Glu Arg Cys Met Ser 
            180                 185                 190         


Pro Pro Ile Ser Met Ala Glu Thr Ser Ala Val Cys Thr Ala Ala Ser 
        195                 200                 205             


Val Ile Arg Asn Ala Lys Gln Pro Leu Leu Ile Ile Gly Lys Gly Ala 
    210                 215                 220                 


Ala Tyr Ala His Ala Glu Glu Ser Ile Lys Lys Leu Val Glu Gln Tyr 
225                 230                 235                 240 


Lys Leu Pro Phe Leu Pro Thr Pro Met Gly Lys Gly Val Val Pro Asp 
                245                 250                 255     


Asn His Pro Tyr Cys Val Gly Ala Ala Arg Ser Arg Ala Leu Gln Phe 
            260                 265                 270         


Ala Asp Val Ile Val Leu Phe Gly Ala Arg Leu Asn Trp Ile Leu His 
        275                 280                 285             


Phe Gly Leu Pro Pro Arg Tyr Gln Pro Asp Val Lys Phe Ile Gln Val 
    290                 295                 300                 


Asp Ile Cys Ala Glu Glu Leu Gly Asn Asn Val Lys Pro Ala Val Thr 
305                 310                 315                 320 


Leu Leu Gly Asn Ile His Ala Val Thr Lys Gln Leu Leu Glu Glu Leu 
                325                 330                 335     


Asp Lys Thr Pro Trp Gln Tyr Pro Pro Glu Ser Lys Trp Trp Lys Thr 
            340                 345                 350         


Leu Arg Glu Lys Met Lys Ser Asn Glu Ala Ala Ser Lys Glu Leu Ala 
        355                 360                 365             


Ser Lys Lys Ser Leu Pro Met Asn Tyr Tyr Thr Val Phe Tyr His Val 
    370                 375                 380                 


Gln Glu Gln Leu Pro Arg Asp Cys Phe Val Val Ser Glu Gly Ala Asn 
385                 390                 395                 400 


Thr Met Asp Ile Gly Arg Thr Val Leu Gln Asn Tyr Leu Pro Arg His 
                405                 410                 415     


Arg Leu Asp Ala Gly Thr Phe Gly Thr Met Gly Val Gly Leu Gly Phe 
            420                 425                 430         


Ala Ile Ala Ala Ala Val Val Ala Lys Asp Arg Ser Pro Gly Gln Trp 
        435                 440                 445             


Ile Ile Cys Val Glu Gly Asp Ser Ala Phe Gly Phe Ser Gly Met Glu 
    450                 455                 460                 


Val Glu Thr Ile Cys Arg Tyr Asn Leu Pro Ile Ile Leu Leu Val Val 
465                 470                 475                 480 


Asn Asn Asn Gly Ile Tyr Gln Gly Phe Asp Thr Asp Thr Trp Lys Glu 
                485                 490                 495     


Met Leu Lys Phe Gln Asp Ala Thr Ala Val Val Pro Pro Met Cys Leu 
            500                 505                 510         


Leu Pro Asn Ser His Tyr Glu Gln Val Met Thr Ala Phe Gly Gly Lys 
        515                 520                 525             


Gly Tyr Phe Val Gln Thr Pro Glu Glu Leu Gln Lys Ser Leu Arg Gln 
    530                 535                 540                 


Ser Leu Ala Asp Thr Thr Lys Pro Ser Leu Ile Asn Ile Met Ile Glu 
545                 550                 555                 560 


Pro Gln Ala Thr Arg Lys Ala Gln Asp Phe His Trp Leu Thr Arg Ser 
                565                 570                 575     


Asn Met 
        


<210>  4852
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HADHA__Homo_sapiens__NP_000173

<400>  4852

Met Val Ala Cys Arg Ala Ile Gly Ile Leu Ser Arg Phe Ser Ala Phe 
1               5                   10                  15      


Arg Ile Leu Arg Ser Arg Gly Tyr Ile Cys Arg Asn Phe Thr Gly Ser 
            20                  25                  30          


Ser Ala Leu Leu Thr Arg Thr His Ile Asn Tyr Gly Val Lys Gly Asp 
        35                  40                  45              


Val Ala Val Val Arg Ile Asn Ser Pro Asn Ser Lys Val Asn Thr Leu 
    50                  55                  60                  


Ser Lys Glu Leu His Ser Glu Phe Ser Glu Val Met Asn Glu Ile Trp 
65                  70                  75                  80  


Ala Ser Asp Gln Ile Arg Ser Ala Val Leu Ile Ser Ser Lys Pro Gly 
                85                  90                  95      


Cys Phe Ile Ala Gly Ala Asp Ile Asn Met Leu Ala Ala Cys Lys Thr 
            100                 105                 110         


Leu Gln Glu Val Thr Gln Leu Ser Gln Glu Ala Gln Arg Ile Val Glu 
        115                 120                 125             


Lys Leu Glu Lys Ser Thr Lys Pro Ile Val Ala Ala Ile Asn Gly Ser 
    130                 135                 140                 


Cys Leu Gly Gly Gly Leu Glu Val Ala Ile Ser Cys Gln Tyr Arg Ile 
145                 150                 155                 160 


Ala Thr Lys Asp Arg Lys Thr Val Leu Gly Thr Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ala Leu Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Lys Met Val 
            180                 185                 190         


Gly Val Pro Ala Ala Leu Asp Met Met Leu Thr Gly Arg Ser Ile Arg 
        195                 200                 205             


Ala Asp Arg Ala Lys Lys Met Gly Leu Val Asp Gln Leu Val Glu Pro 
    210                 215                 220                 


Leu Gly Pro Gly Leu Lys Pro Pro Glu Glu Arg Thr Ile Glu Tyr Leu 
225                 230                 235                 240 


Glu Glu Val Ala Ile Thr Phe Ala Lys Gly Leu Ala Asp Lys Lys Ile 
                245                 250                 255     


Ser Pro Lys Arg Asp Lys Gly Leu Val Glu Lys Leu Thr Ala Tyr Ala 
            260                 265                 270         


Met Thr Ile Pro Phe Val Arg Gln Gln Val Tyr Lys Lys Val Glu Glu 
        275                 280                 285             


Lys Val Arg Lys Gln Thr Lys Gly Leu Tyr Pro Ala Pro Leu Lys Ile 
    290                 295                 300                 


Ile Asp Val Val Lys Thr Gly Ile Glu Gln Gly Ser Asp Ala Gly Tyr 
305                 310                 315                 320 


Leu Cys Glu Ser Gln Lys Phe Gly Glu Leu Val Met Thr Lys Glu Ser 
                325                 330                 335     


Lys Ala Leu Met Gly Leu Tyr His Gly Gln Val Leu Cys Lys Lys Asn 
            340                 345                 350         


Lys Phe Gly Ala Pro Gln Lys Asp Val Lys His Leu Ala Ile Leu Gly 
        355                 360                 365             


Ala Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ser Val Asp Lys Gly 
    370                 375                 380                 


Leu Lys Thr Ile Leu Lys Asp Ala Thr Leu Thr Ala Leu Asp Arg Gly 
385                 390                 395                 400 


Gln Gln Gln Val Phe Lys Gly Leu Asn Asp Lys Val Lys Lys Lys Ala 
                405                 410                 415     


Leu Thr Ser Phe Glu Arg Asp Ser Ile Phe Ser Asn Leu Thr Gly Gln 
            420                 425                 430         


Leu Asp Tyr Gln Gly Phe Glu Lys Ala Asp Met Val Ile Glu Ala Val 
        435                 440                 445             


Phe Glu Asp Leu Ser Leu Lys His Arg Val Leu Lys Glu Val Glu Ala 
    450                 455                 460                 


Val Ile Pro Asp His Cys Ile Phe Ala Ser Asn Thr Ser Ala Leu Pro 
465                 470                 475                 480 


Ile Ser Glu Ile Ala Ala Val Ser Lys Arg Pro Glu Lys Val Ile Gly 
                485                 490                 495     


Met His Tyr Phe Ser Pro Val Asp Lys Met Gln Leu Leu Glu Ile Ile 
            500                 505                 510         


Thr Thr Glu Lys Thr Ser Lys Asp Thr Ser Ala Ser Ala Val Ala Val 
        515                 520                 525             


Gly Leu Lys Gln Gly Lys Val Ile Ile Val Val Lys Asp Gly Pro Gly 
    530                 535                 540                 


Phe Tyr Thr Thr Arg Cys Leu Ala Pro Met Met Ser Glu Val Ile Arg 
545                 550                 555                 560 


Ile Leu Gln Glu Gly Val Asp Pro Lys Lys Leu Asp Ser Leu Thr Thr 
                565                 570                 575     


Ser Phe Gly Phe Pro Val Gly Ala Ala Thr Leu Val Asp Glu Val Gly 
            580                 585                 590         


Val Asp Val Ala Lys His Val Ala Glu Asp Leu Gly Lys Val Phe Gly 
        595                 600                 605             


Glu Arg Phe Gly Gly Gly Asn Pro Glu Leu Leu Thr Gln Met Val Ser 
    610                 615                 620                 


Lys Gly Phe Leu Gly Arg Lys Ser Gly Lys Gly Phe Tyr Ile Tyr Gln 
625                 630                 635                 640 


Glu Gly Val Lys Arg Lys Asp Leu Asn Ser Asp Met Asp Ser Ile Leu 
                645                 650                 655     


Ala Ser Leu Lys Leu Pro Pro Lys Ser Glu Val Ser Ser Asp Glu Asp 
            660                 665                 670         


Ile Gln Phe Arg Leu Val Thr Arg Phe Val Asn Glu Ala Val Met Cys 
        675                 680                 685             


Leu Gln Glu Gly Ile Leu Ala Thr Pro Ala Glu Gly Asp Ile Gly Ala 
    690                 695                 700                 


Val Phe Gly Leu Gly Phe Pro Pro Cys Leu Gly Gly Pro Phe Arg Phe 
705                 710                 715                 720 


Val Asp Leu Tyr Gly Ala Gln Lys Ile Val Asp Arg Leu Lys Lys Tyr 
                725                 730                 735     


Glu Ala Ala Tyr Gly Lys Gln Phe Thr Pro Cys Gln Leu Leu Ala Asp 
            740                 745                 750         


His Ala Asn Ser Pro Asn Lys Lys Phe Tyr Gln 
        755                 760             


<210>  4853
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HADHB__Homo_sapiens__NP_001268441

<400>  4853

Met Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser Lys 
1               5                   10                  15      


Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln Leu 
            20                  25                  30          


Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala Lys 
        35                  40                  45              


Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro Phe 
    50                  55                  60                  


Leu Leu Ser Gly Thr Ser Gly Leu Leu His Arg Thr Ser Val Pro Lys 
65                  70                  75                  80  


Glu Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys 
                85                  90                  95      


Thr Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp 
            100                 105                 110         


Lys Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln 
        115                 120                 125             


Ala Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln Cys Asp Val 
    130                 135                 140                 


Ile Val Ala Gly Gly Val Glu Leu Met Ser Asp Val Pro Ile Arg His 
145                 150                 155                 160 


Ser Arg Lys Met Arg Lys Leu Met Leu Asp Leu Asn Lys Ala Lys Ser 
                165                 170                 175     


Met Gly Gln Arg Leu Ser Leu Ile Ser Lys Phe Arg Phe Asn Phe Leu 
            180                 185                 190         


Ala Pro Glu Leu Pro Ala Val Ser Glu Phe Ser Thr Ser Glu Thr Met 
        195                 200                 205             


Gly His Ser Ala Asp Arg Leu Ala Ala Ala Phe Ala Val Ser Arg Leu 
    210                 215                 220                 


Glu Gln Asp Glu Tyr Ala Leu Arg Ser His Ser Leu Ala Lys Lys Ala 
225                 230                 235                 240 


Gln Asp Glu Gly Leu Leu Ser Asp Val Val Pro Phe Lys Val Pro Gly 
                245                 250                 255     


Lys Asp Thr Val Thr Lys Asp Asn Gly Ile Arg Pro Ser Ser Leu Glu 
            260                 265                 270         


Gln Met Ala Lys Leu Lys Pro Ala Phe Ile Lys Pro Tyr Gly Thr Val 
        275                 280                 285             


Thr Ala Ala Asn Ser Ser Phe Leu Thr Asp Gly Ala Ser Ala Met Leu 
    290                 295                 300                 


Ile Met Ala Glu Glu Lys Ala Leu Ala Met Gly Tyr Lys Pro Lys Ala 
305                 310                 315                 320 


Tyr Leu Arg Asp Phe Met Tyr Val Ser Gln Asp Pro Lys Asp Gln Leu 
                325                 330                 335     


Leu Leu Gly Pro Thr Tyr Ala Thr Pro Lys Val Leu Glu Lys Ala Gly 
            340                 345                 350         


Leu Thr Met Asn Asp Ile Asp Ala Phe Glu Phe His Glu Ala Phe Ser 
        355                 360                 365             


Gly Gln Ile Leu Ala Asn Phe Lys Ala Met Asp Ser Asp Trp Phe Ala 
    370                 375                 380                 


Glu Asn Tyr Met Gly Arg Lys Thr Lys Val Gly Leu Pro Pro Leu Glu 
385                 390                 395                 400 


Lys Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Gly His Pro Phe Gly 
                405                 410                 415     


Ala Thr Gly Cys Arg Leu Val Met Ala Ala Ala Asn Arg Leu Arg Lys 
            420                 425                 430         


Glu Gly Gly Gln Tyr Gly Leu Val Ala Ala Cys Ala Ala Gly Gly Gln 
        435                 440                 445             


Gly His Ala Met Ile Val Glu Ala Tyr Pro Lys 
    450                 455                 


<210>  4854
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HADH__Homo_sapiens__NP_001171634

<400>  4854

Met Ala Phe Val Thr Arg Gln Phe Met Arg Ser Val Ser Ser Ser Ser 
1               5                   10                  15      


Thr Ala Ser Ala Ser Ala Lys Lys Ile Ile Val Lys His Val Thr Val 
            20                  25                  30          


Ile Gly Gly Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ala Ala Ala 
        35                  40                  45              


Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu Asp Ile Leu Ala 
    50                  55                  60                  


Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys Val Ala Lys Lys 
65                  70                  75                  80  


Lys Phe Ala Glu Asn Pro Lys Ala Gly Asp Glu Phe Val Glu Lys Thr 
                85                  90                  95      


Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser Val Val His Ser 
            100                 105                 110         


Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu Lys Val Lys Asn 
        115                 120                 125             


Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu His Thr Ile Phe 
    130                 135                 140                 


Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile Ala Asn Ala Thr 
145                 150                 155                 160 


Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe Asn Pro Val Pro 
                165                 170                 175     


Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met Thr Ser Gln Lys 
            180                 185                 190         


Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu Gly Lys His Pro 
        195                 200                 205             


Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn Arg Leu Leu Val 
    210                 215                 220                 


Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg Asp Phe Gln Thr 
225                 230                 235                 240 


Cys Gly Asp Ser Asn Ser Gly Leu Gly Phe Ser Leu Lys Gly Asp Ala 
                245                 250                 255     


Ser Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala Gly Tyr Pro 
            260                 265                 270         


Met Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp Thr Thr Lys 
        275                 280                 285             


Phe Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn Pro Leu His 
    290                 295                 300                 


Gln Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn Lys Phe Gly 
305                 310                 315                 320 


Lys Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys 
                325                 330     


<210>  4855
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAGH__Homo_sapiens__NP_001035517

<400>  4855

Met Lys Val Glu Val Leu Pro Ala Leu Thr Asp Asn Tyr Met Tyr Leu 
1               5                   10                  15      


Val Ile Asp Asp Glu Thr Lys Glu Ala Ala Ile Val Asp Pro Val Gln 
            20                  25                  30          


Pro Gln Lys Val Val Asp Ala Ala Arg Lys His Gly Val Lys Leu Thr 
        35                  40                  45              


Thr Val Leu Thr Thr His His His Trp Asp His Ala Gly Gly Asn Glu 
    50                  55                  60                  


Lys Leu Val Lys Leu Glu Ser Gly Leu Lys Val Tyr Gly Gly Asp Asp 
65                  70                  75                  80  


Arg Ile Gly Ala Leu Thr His Lys Ile Thr His Leu Ser Thr Leu Gln 
                85                  90                  95      


Val Gly Ser Leu Asn Val Lys Cys Leu Ala Thr Pro Cys His Thr Ser 
            100                 105                 110         


Gly His Ile Cys Tyr Phe Val Ser Lys Pro Gly Gly Ser Glu Pro Pro 
        115                 120                 125             


Ala Val Phe Thr Gly Asp Thr Leu Phe Val Ala Gly Cys Gly Lys Phe 
    130                 135                 140                 


Tyr Glu Gly Thr Ala Asp Glu Met Cys Lys Ala Leu Leu Glu Val Leu 
145                 150                 155                 160 


Gly Arg Leu Pro Pro Asp Thr Arg Val Tyr Cys Gly His Glu Tyr Thr 
                165                 170                 175     


Ile Asn Asn Leu Lys Phe Ala Arg His Val Glu Pro Gly Asn Ala Ala 
            180                 185                 190         


Ile Arg Glu Lys Leu Ala Trp Ala Lys Glu Lys Tyr Ser Ile Gly Glu 
        195                 200                 205             


Pro Thr Val Pro Ser Thr Leu Ala Glu Glu Phe Thr Tyr Asn Pro Phe 
    210                 215                 220                 


Met Arg Val Arg Glu Lys Thr Val Gln Gln His Ala Gly Glu Thr Asp 
225                 230                 235                 240 


Pro Val Thr Thr Met Arg Ala Val Arg Arg Glu Lys Asp Gln Phe Lys 
                245                 250                 255     


Met Pro Arg Asp 
            260 


<210>  4856
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAL__Homo_sapiens__NP_001245262

<400>  4856

Met Leu Leu Ala Leu Arg Ile Asn Val Leu Ala Lys Gly Tyr Ser Gly 
1               5                   10                  15      


Ile Ser Leu Glu Thr Leu Lys Gln Val Ile Glu Met Phe Asn Ala Ser 
            20                  25                  30          


Cys Leu Pro Tyr Val Pro Glu Lys Gly Thr Val Gly Ala Ser Gly Asp 
        35                  40                  45              


Leu Ala Pro Leu Ser His Leu Ala Leu Gly Leu Val Gly Glu Gly Lys 
    50                  55                  60                  


Met Trp Ser Pro Lys Ser Gly Trp Ala Asp Ala Lys Tyr Val Leu Glu 
65                  70                  75                  80  


Ala His Gly Leu Lys Pro Val Ile Leu Lys Pro Lys Glu Gly Leu Ala 
                85                  90                  95      


Leu Ile Asn Gly Thr Gln Met Ile Thr Ser Leu Gly Cys Glu Ala Val 
            100                 105                 110         


Glu Arg Ala Ser Ala Ile Ala Arg Gln Ala Asp Ile Val Ala Ala Leu 
        115                 120                 125             


Thr Leu Glu Val Leu Lys Gly Thr Thr Lys Ala Phe Asp Thr Asp Ile 
    130                 135                 140                 


His Ala Leu Arg Pro His Arg Gly Gln Ile Glu Val Ala Phe Arg Phe 
145                 150                 155                 160 


Arg Ser Leu Leu Asp Ser Asp His His Pro Ser Glu Ile Ala Glu Ser 
                165                 170                 175     


His Arg Phe Cys Asp Arg Val Gln Asp Ala Tyr Thr Leu Arg Cys Cys 
            180                 185                 190         


Pro Gln Val His Gly Val Val Asn Asp Thr Ile Ala Phe Val Lys Asn 
        195                 200                 205             


Ile Ile Thr Thr Glu Leu Asn Ser Ala Thr Asp Asn Pro Met Val Phe 
    210                 215                 220                 


Ala Asn Arg Gly Glu Thr Val Ser Gly Gly Asn Phe His Gly Glu Tyr 
225                 230                 235                 240 


Pro Ala Lys Ala Leu Asp Tyr Leu Ala Ile Gly Ile His Glu Leu Ala 
                245                 250                 255     


Ala Ile Ser Glu Arg Arg Ile Glu Arg Leu Cys Asn Pro Ser Leu Ser 
            260                 265                 270         


Glu Leu Pro Ala Phe Leu Val Ala Glu Gly Gly Leu Asn Ser Gly Phe 
        275                 280                 285             


Met Ile Ala His Cys Thr Ala Ala Ala Leu Val Ser Glu Asn Lys Ala 
    290                 295                 300                 


Leu Cys His Pro Ser Ser Val Asp Ser Leu Ser Thr Ser Ala Ala Thr 
305                 310                 315                 320 


Glu Asp His Val Ser Met Gly Gly Trp Ala Ala Arg Lys Ala Leu Arg 
                325                 330                 335     


Val Ile Glu His Val Glu Gln Val Leu Ala Ile Glu Leu Leu Ala Ala 
            340                 345                 350         


Cys Gln Gly Ile Glu Phe Leu Arg Pro Leu Lys Thr Thr Thr Pro Leu 
        355                 360                 365             


Glu Lys Val Tyr Asp Leu Val Arg Ser Val Val Arg Pro Trp Ile Lys 
    370                 375                 380                 


Asp Arg Phe Met Ala Pro Asp Ile Glu Ala Ala His Arg Leu Leu Leu 
385                 390                 395                 400 


Glu Gln Lys Val Trp Glu Val Ala Ala Pro Tyr Ile Glu Lys Tyr Arg 
                405                 410                 415     


Met Glu His Ile Pro Glu Ser Arg Pro Leu Ser Pro Thr Ala Phe Ser 
            420                 425                 430         


Leu Gln Phe Leu His Lys Lys Ser Thr Lys Ile Pro Glu Ser Glu Asp 
        435                 440                 445             


Leu 
    


<210>  4857
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAMP__Homo_sapiens__NP_066998

<400>  4857

Met Ala Leu Ser Ser Gln Ile Trp Ala Ala Cys Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ala Ser Leu Thr Ser Gly Ser Val Phe Pro Gln Gln Thr Gly 
            20                  25                  30          


Gln Leu Ala Glu Leu Gln Pro Gln Asp Arg Ala Gly Ala Arg Ala Ser 
        35                  40                  45              


Trp Met Pro Met Phe Gln Arg Arg Arg Arg Arg Asp Thr His Phe Pro 
    50                  55                  60                  


Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg Ser Lys Cys Gly Met 
65                  70                  75                  80  


Cys Cys Lys Thr 
                


<210>  4858
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAND1__Homo_sapiens__NP_004812

<400>  4858

Met Asn Leu Val Gly Ser Tyr Ala His His His His His His His Pro 
1               5                   10                  15      


His Pro Ala His Pro Met Leu His Glu Pro Phe Leu Phe Gly Pro Ala 
            20                  25                  30          


Ser Arg Cys His Gln Glu Arg Pro Tyr Phe Gln Ser Trp Leu Leu Ser 
        35                  40                  45              


Pro Ala Asp Ala Ala Pro Asp Phe Pro Ala Gly Gly Pro Pro Pro Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Thr Ala Tyr Gly Pro Asp Ala Arg Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Gly Arg Leu Glu Ala Leu Gly Gly Arg Leu Gly Arg Arg Lys 
                85                  90                  95      


Gly Ser Gly Pro Lys Lys Glu Arg Arg Arg Thr Glu Ser Ile Asn Ser 
            100                 105                 110         


Ala Phe Ala Glu Leu Arg Glu Cys Ile Pro Asn Val Pro Ala Asp Thr 
        115                 120                 125             


Lys Leu Ser Lys Ile Lys Thr Leu Arg Leu Ala Thr Ser Tyr Ile Ala 
    130                 135                 140                 


Tyr Leu Met Asp Val Leu Ala Lys Asp Ala Gln Ser Gly Asp Pro Glu 
145                 150                 155                 160 


Ala Phe Lys Ala Glu Leu Lys Lys Ala Asp Gly Gly Arg Glu Ser Lys 
                165                 170                 175     


Arg Lys Arg Glu Leu Gln Gln His Glu Gly Phe Pro Pro Ala Leu Gly 
            180                 185                 190         


Pro Val Glu Lys Arg Ile Lys Gly Arg Thr Gly Trp Pro Gln Gln Val 
        195                 200                 205             


Trp Ala Leu Glu Leu Asn Gln 
    210                 215 


<210>  4859
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAND2__Homo_sapiens__NP_068808

<400>  4859

Met Ser Leu Val Gly Gly Phe Pro His His Pro Val Val His His Glu 
1               5                   10                  15      


Gly Tyr Pro Phe Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ser Arg Cys Ser His Glu Glu Asn Pro Tyr Phe His Gly Trp Leu Ile 
        35                  40                  45              


Gly His Pro Glu Met Ser Pro Pro Asp Tyr Ser Met Ala Leu Ser Tyr 
    50                  55                  60                  


Ser Pro Glu Tyr Ala Ser Gly Ala Ala Gly Leu Asp His Ser His Tyr 
65                  70                  75                  80  


Gly Gly Val Pro Pro Gly Ala Gly Pro Pro Gly Leu Gly Gly Pro Arg 
                85                  90                  95      


Pro Val Lys Arg Arg Gly Thr Ala Asn Arg Lys Glu Arg Arg Arg Thr 
            100                 105                 110         


Gln Ser Ile Asn Ser Ala Phe Ala Glu Leu Arg Glu Cys Ile Pro Asn 
        115                 120                 125             


Val Pro Ala Asp Thr Lys Leu Ser Lys Ile Lys Thr Leu Arg Leu Ala 
    130                 135                 140                 


Thr Ser Tyr Ile Ala Tyr Leu Met Asp Leu Leu Ala Lys Asp Asp Gln 
145                 150                 155                 160 


Asn Gly Glu Ala Glu Ala Phe Lys Ala Glu Ile Lys Lys Thr Asp Val 
                165                 170                 175     


Lys Glu Glu Lys Arg Lys Lys Glu Leu Asn Glu Ile Leu Lys Ser Thr 
            180                 185                 190         


Val Ser Ser Asn Asp Lys Lys Thr Lys Gly Arg Thr Gly Trp Pro Gln 
        195                 200                 205             


His Val Trp Ala Leu Glu Leu Lys Gln 
    210                 215         


<210>  4860
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAO1__Homo_sapiens__NP_060015

<400>  4860

Met Leu Pro Arg Leu Ile Cys Ile Asn Asp Tyr Glu Gln His Ala Lys 
1               5                   10                  15      


Ser Val Leu Pro Lys Ser Ile Tyr Asp Tyr Tyr Arg Ser Gly Ala Asn 
            20                  25                  30          


Asp Glu Glu Thr Leu Ala Asp Asn Ile Ala Ala Phe Ser Arg Trp Lys 
        35                  40                  45              


Leu Tyr Pro Arg Met Leu Arg Asn Val Ala Glu Thr Asp Leu Ser Thr 
    50                  55                  60                  


Ser Val Leu Gly Gln Arg Val Ser Met Pro Ile Cys Val Gly Ala Thr 
65                  70                  75                  80  


Ala Met Gln Arg Met Ala His Val Asp Gly Glu Leu Ala Thr Val Arg 
                85                  90                  95      


Ala Cys Gln Ser Leu Gly Thr Gly Met Met Leu Ser Ser Trp Ala Thr 
            100                 105                 110         


Ser Ser Ile Glu Glu Val Ala Glu Ala Gly Pro Glu Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Leu Tyr Ile Tyr Lys Asp Arg Glu Val Thr Lys Lys Leu Val 
    130                 135                 140                 


Arg Gln Ala Glu Lys Met Gly Tyr Lys Ala Ile Phe Val Thr Val Asp 
145                 150                 155                 160 


Thr Pro Tyr Leu Gly Asn Arg Leu Asp Asp Val Arg Asn Arg Phe Lys 
                165                 170                 175     


Leu Pro Pro Gln Leu Arg Met Lys Asn Phe Glu Thr Ser Thr Leu Ser 
            180                 185                 190         


Phe Ser Pro Glu Glu Asn Phe Gly Asp Asp Ser Gly Leu Ala Ala Tyr 
        195                 200                 205             


Val Ala Lys Ala Ile Asp Pro Ser Ile Ser Trp Glu Asp Ile Lys Trp 
    210                 215                 220                 


Leu Arg Arg Leu Thr Ser Leu Pro Ile Val Ala Lys Gly Ile Leu Arg 
225                 230                 235                 240 


Gly Asp Asp Ala Arg Glu Ala Val Lys His Gly Leu Asn Gly Ile Leu 
                245                 250                 255     


Val Ser Asn His Gly Ala Arg Gln Leu Asp Gly Val Pro Ala Thr Ile 
            260                 265                 270         


Asp Val Leu Pro Glu Ile Val Glu Ala Val Glu Gly Lys Val Glu Val 
        275                 280                 285             


Phe Leu Asp Gly Gly Val Arg Lys Gly Thr Asp Val Leu Lys Ala Leu 
    290                 295                 300                 


Ala Leu Gly Ala Lys Ala Val Phe Val Gly Arg Pro Ile Val Trp Gly 
305                 310                 315                 320 


Leu Ala Phe Gln Gly Glu Lys Gly Val Gln Asp Val Leu Glu Ile Leu 
                325                 330                 335     


Lys Glu Glu Phe Arg Leu Ala Met Ala Leu Ser Gly Cys Gln Asn Val 
            340                 345                 350         


Lys Val Ile Asp Lys Thr Leu Val Arg Lys Asn Pro Leu Ala Val Ser 
        355                 360                 365             


Lys Ile 
    370 


<210>  4861
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAO2__Homo_sapiens__XP_011539860

<400>  4861

Met Ser Leu Val Cys Leu Thr Asp Phe Gln Ala His Ala Arg Glu Gln 
1               5                   10                  15      


Leu Ser Lys Ser Thr Arg Asp Phe Ile Glu Gly Gly Ala Asp Asp Ser 
            20                  25                  30          


Ile Thr Arg Asp Asp Asn Ile Ala Ala Phe Lys Arg Ile Arg Leu Arg 
        35                  40                  45              


Pro Arg Tyr Leu Arg Asp Val Ser Glu Val Asp Thr Arg Thr Thr Ile 
    50                  55                  60                  


Gln Gly Glu Glu Ile Ser Ala Pro Ile Cys Ile Ala Pro Thr Gly Phe 
65                  70                  75                  80  


His Cys Leu Val Trp Pro Asp Gly Glu Met Ser Thr Ala Arg Ala Pro 
                85                  90                  95      


Glu Gly Leu Arg Trp Phe Gln Leu Tyr Val His Pro Asp Leu Gln Leu 
            100                 105                 110         


Asn Lys Gln Leu Ile Gln Arg Val Glu Ser Leu Gly Phe Lys Ala Leu 
        115                 120                 125             


Val Ile Thr Leu Asp Thr Pro Val Cys Gly Asn Arg Arg His Asp Ile 
    130                 135                 140                 


Arg Asn Gln Leu Arg Arg Asn Leu Thr Leu Thr Asp Leu Gln Ser Pro 
145                 150                 155                 160 


Lys Lys Gly Asn Ala Ile Pro Tyr Phe Gln Met Thr Pro Ile Ser Thr 
                165                 170                 175     


Ser Leu Cys Trp Asn Asp Leu Ser Trp Phe Gln Ser Ile Thr Arg Leu 
            180                 185                 190         


Pro Ile Ile Leu Lys Gly Ile Leu Thr Lys Glu Asp Ala Glu Leu Ala 
        195                 200                 205             


Val Lys His Asn Val Gln Gly Ile Ile Val Ser Asn His Gly Gly Arg 
    210                 215                 220                 


Gln Leu Asp Glu Val Leu Ala Ser Ile Asp Ala Leu Thr Glu Val Val 
225                 230                 235                 240 


Ala Ala Val Lys Gly Lys Ile Glu Val Tyr Leu Asp Gly Gly Val Arg 
                245                 250                 255     


Thr Gly Asn Asp Val Leu Lys Ala Leu Ala Leu Gly Ala Lys Cys Ile 
            260                 265                 270         


Phe Leu Gly Arg Pro Ile Leu Trp Gly Leu Ala Cys Lys Ala Ala Gly 
        275                 280                 285             


Arg Ser Leu Arg Ser Ile Glu Thr Trp Ser Ser Phe Pro Gly Cys Lys 
    290                 295                 300                 


Lys Lys Gly Pro Ile Thr Arg Leu Leu Arg Leu Pro Thr Gly Gly Ser 
305                 310                 315                 320 


Gln Thr His Ser Thr Val Cys Asp Ala Val Leu Pro Gly Pro His Ser 
                325                 330                 335     


Val Arg Arg Leu Met Ala His Ile Ser His Ile Ser Asn Thr Thr Thr 
            340                 345                 350         


Pro Val Leu Gln Ala Leu Gln Thr Pro Val Phe Pro Lys Cys Ser Met 
        355                 360                 365             


Pro Phe Phe Val Ser Leu Thr Ile Ile Cys Cys Ser Leu Ala 
    370                 375                 380         


<210>  4862
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAP1__Homo_sapiens__NP_001073339

<400>  4862

Met Arg Pro Lys Arg Leu Gly Arg Cys Cys Ala Gly Ser Arg Leu Gly 
1               5                   10                  15      


Pro Gly Asp Pro Ala Ala Leu Thr Cys Ala Pro Ser Pro Ser Ala Ser 
            20                  25                  30          


Pro Ala Pro Glu Pro Ser Ala Gln Pro Gln Ala Arg Gly Thr Gly Gln 
        35                  40                  45              


Arg Val Gly Ser Arg Ala Thr Ser Gly Ser Gln Phe Leu Ser Glu Ala 
    50                  55                  60                  


Arg Thr Gly Ala Arg Pro Ala Ser Glu Ala Gly Ala Lys Ala Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Ser Ala Phe Ser Ala Ile Gln Gly Asp Val Arg Ser Met 
                85                  90                  95      


Pro Asp Asn Ser Asp Ala Pro Trp Thr Arg Phe Val Phe Gln Gly Pro 
            100                 105                 110         


Phe Gly Ser Arg Ala Thr Gly Arg Gly Thr Gly Lys Ala Ala Gly Ile 
        115                 120                 125             


Trp Lys Thr Pro Ala Ala Tyr Val Gly Arg Arg Pro Gly Val Ser Gly 
    130                 135                 140                 


Pro Glu Arg Ala Ala Phe Ile Arg Glu Leu Glu Glu Ala Leu Cys Pro 
145                 150                 155                 160 


Asn Leu Pro Pro Pro Val Lys Lys Ile Thr Gln Glu Asp Val Lys Val 
                165                 170                 175     


Met Leu Tyr Leu Leu Glu Glu Val Cys Thr Ala Phe Leu Ile Gln Leu 
            180                 185                 190         


Leu Pro Pro Val Trp Glu Ser Val Thr Tyr Gly Met Val Leu Gln Arg 
        195                 200                 205             


Glu Arg Asp Leu Asn Thr Ala Ala Arg Ile Gly Gln Ser Leu Val Lys 
    210                 215                 220                 


Gln Asn Ser Val Leu Met Glu Glu Asn Ser Lys Leu Glu Ala Leu Leu 
225                 230                 235                 240 


Gly Ser Ala Lys Glu Glu Ile Leu Tyr Leu Arg His Gln Val Asn Leu 
                245                 250                 255     


Arg Asp Glu Leu Leu Gln Leu Tyr Ser Asp Ser Asp Glu Glu Asp Glu 
            260                 265                 270         


Asp Glu Glu Glu Glu Glu Glu Glu Lys Glu Ala Glu Glu Glu Gln Glu 
        275                 280                 285             


Glu Glu Glu Ala Glu Glu Asp Leu Gln Cys Ala His Pro Cys Asp Ala 
    290                 295                 300                 


Pro Lys Leu Ile Ser Gln Glu Ala Leu Leu His Gln His His Cys Pro 
305                 310                 315                 320 


Gln Leu Glu Ala Leu Gln Glu Lys Leu Arg Leu Leu Glu Glu Glu Asn 
                325                 330                 335     


His Gln Leu Arg Glu Glu Ala Ser Gln Leu Asp Thr Leu Glu Asp Glu 
            340                 345                 350         


Glu Gln Met Leu Ile Leu Glu Cys Val Glu Gln Phe Ser Glu Ala Ser 
        355                 360                 365             


Gln Gln Met Ala Glu Leu Ser Glu Val Leu Val Leu Arg Leu Glu Asn 
    370                 375                 380                 


Tyr Glu Arg Gln Gln Gln Glu Val Ala Arg Leu Gln Ala Gln Val Leu 
385                 390                 395                 400 


Lys Leu Gln Gln Arg Cys Arg Met Glu Thr Leu Pro Gly Phe Gln Glu 
                405                 410                 415     


Thr Leu Ala Glu Glu Leu Arg Thr Ser Leu Arg Arg Met Ile Ser Asp 
            420                 425                 430         


Pro Val Tyr Phe Met Glu Arg Asn Tyr Glu Met Pro Arg Gly Asp Thr 
        435                 440                 445             


Ser Ser Leu Arg Tyr Asp Phe Arg Tyr Ser Glu Asp Arg Glu Gln Val 
    450                 455                 460                 


Arg Gly Phe Glu Ala Glu Glu Gly Leu Met Leu Ala Ala Asp Ile Met 
465                 470                 475                 480 


Arg Gly Glu Asp Phe Thr Pro Ala Glu Glu Phe Val Pro Gln Glu Glu 
                485                 490                 495     


Leu Gly Ala Ala Lys Lys Val Pro Ala Glu Glu Gly Val Met Glu Glu 
            500                 505                 510         


Ala Glu Leu Val Ser Glu Glu Thr Glu Gly Trp Glu Glu Val Glu Leu 
        515                 520                 525             


Glu Leu Asp Glu Ala Thr Arg Met Asn Val Val Thr Ser Ala Leu Glu 
    530                 535                 540                 


Ala Ser Gly Leu Gly Pro Ser His Leu Asp Met Asn Tyr Val Leu Gln 
545                 550                 555                 560 


Gln Leu Ala Asn Trp Gln Asp Ala His Tyr Arg Arg Gln Leu Arg Trp 
                565                 570                 575     


Lys Met Leu Gln Lys Gly Glu Cys Pro His Gly Ala Leu Pro Ala Ala 
            580                 585                 590         


Ser Arg Thr Ser Cys Arg Ser Ser Cys Arg 
        595                 600         


<210>  4863
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAPLN1__Homo_sapiens__NP_001875

<400>  4863

Met Lys Ser Leu Leu Leu Leu Val Leu Ile Ser Ile Cys Trp Ala Asp 
1               5                   10                  15      


His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His Ile 
            20                  25                  30          


Gln Ala Glu Asn Gly Pro His Leu Leu Val Glu Ala Glu Gln Ala Lys 
        35                  40                  45              


Val Phe Ser His Arg Gly Gly Asn Val Thr Leu Pro Cys Lys Phe Tyr 
    50                  55                  60                  


Arg Asp Pro Thr Ala Phe Gly Ser Gly Ile His Lys Ile Arg Ile Lys 
65                  70                  75                  80  


Trp Thr Lys Leu Thr Ser Asp Tyr Leu Lys Glu Val Asp Val Phe Val 
                85                  90                  95      


Ser Met Gly Tyr His Lys Lys Thr Tyr Gly Gly Tyr Gln Gly Arg Val 
            100                 105                 110         


Phe Leu Lys Gly Gly Ser Asp Ser Asp Ala Ser Leu Val Ile Thr Asp 
        115                 120                 125             


Leu Thr Leu Glu Asp Tyr Gly Arg Tyr Lys Cys Glu Val Ile Glu Gly 
    130                 135                 140                 


Leu Glu Asp Asp Thr Val Val Val Ala Leu Asp Leu Gln Gly Val Val 
145                 150                 155                 160 


Phe Pro Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu 
                165                 170                 175     


Ala Gln Gln Ala Cys Leu Asp Gln Asp Ala Val Ile Ala Ser Phe Asp 
            180                 185                 190         


Gln Leu Tyr Asp Ala Trp Arg Gly Gly Leu Asp Trp Cys Asn Ala Gly 
        195                 200                 205             


Trp Leu Ser Asp Gly Ser Val Gln Tyr Pro Ile Thr Lys Pro Arg Glu 
    210                 215                 220                 


Pro Cys Gly Gly Gln Asn Thr Val Pro Gly Val Arg Asn Tyr Gly Phe 
225                 230                 235                 240 


Trp Asp Lys Asp Lys Ser Arg Tyr Asp Val Phe Cys Phe Thr Ser Asn 
                245                 250                 255     


Phe Asn Gly Arg Phe Tyr Tyr Leu Ile His Pro Thr Lys Leu Thr Tyr 
            260                 265                 270         


Asp Glu Ala Val Gln Ala Cys Leu Asn Asp Gly Ala Gln Ile Ala Lys 
        275                 280                 285             


Val Gly Gln Ile Phe Ala Ala Trp Lys Ile Leu Gly Tyr Asp Arg Cys 
    290                 295                 300                 


Asp Ala Gly Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Ser Arg 
305                 310                 315                 320 


Pro Arg Arg Arg Cys Ser Pro Thr Glu Ala Ala Val Arg Phe Val Gly 
                325                 330                 335     


Phe Pro Asp Lys Lys His Lys Leu Tyr Gly Val Tyr Cys Phe Arg Ala 
            340                 345                 350         


Tyr Asn 
        


<210>  4864
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAPLN4__Homo_sapiens__NP_075378

<400>  4864

Met Val Cys Ala Arg Ala Ala Leu Gly Pro Gly Ala Leu Trp Ala Ala 
1               5                   10                  15      


Ala Trp Gly Val Leu Leu Leu Thr Ala Pro Ala Gly Ala Gln Arg Gly 
            20                  25                  30          


Arg Lys Lys Val Val His Val Leu Glu Gly Glu Ser Gly Ser Val Val 
        35                  40                  45              


Val Gln Thr Ala Pro Gly Gln Val Val Ser His Arg Gly Gly Thr Ile 
    50                  55                  60                  


Val Leu Pro Cys Arg Tyr His Tyr Glu Ala Ala Ala His Gly His Asp 
65                  70                  75                  80  


Gly Val Arg Leu Lys Trp Thr Lys Val Val Asp Pro Leu Ala Phe Thr 
                85                  90                  95      


Asp Val Phe Val Ala Leu Gly Pro Gln His Arg Ala Phe Gly Ser Tyr 
            100                 105                 110         


Arg Gly Arg Ala Glu Leu Gln Gly Asp Gly Pro Gly Asp Ala Ser Leu 
        115                 120                 125             


Val Leu Arg Asn Val Thr Leu Gln Asp Tyr Gly Arg Tyr Glu Cys Glu 
    130                 135                 140                 


Val Thr Asn Glu Leu Glu Asp Asp Ala Gly Met Val Lys Leu Asp Leu 
145                 150                 155                 160 


Glu Gly Val Val Phe Pro Tyr His Pro Arg Gly Gly Arg Tyr Lys Leu 
                165                 170                 175     


Thr Phe Ala Glu Ala Gln Arg Ala Cys Ala Glu Gln Asp Gly Ile Leu 
            180                 185                 190         


Ala Ser Ala Glu Gln Leu His Ala Ala Trp Arg Asp Gly Leu Asp Trp 
        195                 200                 205             


Cys Asn Ala Gly Trp Leu Arg Asp Gly Ser Val Gln Tyr Pro Val Asn 
    210                 215                 220                 


Arg Pro Arg Glu Pro Cys Gly Gly Leu Gly Gly Thr Gly Ser Ala Gly 
225                 230                 235                 240 


Gly Gly Gly Asp Ala Asn Gly Gly Leu Arg Asn Tyr Gly Tyr Arg His 
                245                 250                 255     


Asn Ala Glu Glu Arg Tyr Asp Ala Phe Cys Phe Thr Ser Asn Leu Pro 
            260                 265                 270         


Gly Arg Val Phe Phe Leu Lys Pro Leu Arg Pro Val Pro Phe Ser Gly 
        275                 280                 285             


Ala Ala Arg Ala Cys Ala Ala Arg Gly Ala Ala Val Ala Lys Val Gly 
    290                 295                 300                 


Gln Leu Phe Ala Ala Trp Lys Leu Gln Leu Leu Asp Arg Cys Thr Ala 
305                 310                 315                 320 


Gly Trp Leu Ala Asp Gly Ser Ala Arg Tyr Pro Ile Val Asn Pro Arg 
                325                 330                 335     


Ala Arg Cys Gly Gly Arg Arg Pro Gly Val Arg Ser Leu Gly Phe Pro 
            340                 345                 350         


Asp Ala Thr Arg Arg Leu Phe Gly Val Tyr Cys Tyr Arg Ala Pro Gly 
        355                 360                 365             


Ala Pro Asp Pro Ala Pro Gly Gly Trp Gly Trp Gly Trp Ala Gly Gly 
    370                 375                 380                 


Gly Gly Trp Ala Gly Gly Ala Arg Asp Pro Ala Ala Trp Thr Pro Leu 
385                 390                 395                 400 


His Val 
        


<210>  4865
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HARS2__Homo_sapiens__NP_001265660

<400>  4865

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Gly Thr Arg Asp Leu Ser Pro Gln His Met Val Val 
        35                  40                  45              


Arg Glu Lys Ile Leu Asp Leu Val Ile Ser Cys Phe Lys Arg His Gly 
    50                  55                  60                  


Ala Lys Gly Met Asp Thr Pro Ala Phe Glu Leu Lys Glu Thr Leu Thr 
65                  70                  75                  80  


Glu Lys Tyr Gly Glu Asp Ser Gly Leu Met Tyr Asp Leu Lys Asp Gln 
                85                  90                  95      


Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala 
            100                 105                 110         


Arg Tyr Leu Ala Met Asn Lys Val Lys Lys Met Lys Arg Tyr His Val 
        115                 120                 125             


Gly Lys Val Trp Arg Arg Glu Ser Pro Thr Ile Val Gln Gly Arg Tyr 
    130                 135                 140                 


Arg Glu Phe Cys Gln Cys Asp Phe Asp Ile Ala Gly Gln Phe Asp Pro 
145                 150                 155                 160 


Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser 
                165                 170                 175     


Gly Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn Asp Arg Arg Ile 
            180                 185                 190         


Val Asp Gly Met Phe Ala Val Cys Gly Val Pro Glu Ser Lys Phe Arg 
        195                 200                 205             


Ala Ile Cys Ser Ser Ile Asp Lys Leu Asp Lys Met Ala Trp Lys Asp 
    210                 215                 220                 


Val Arg His Glu Met Val Val Lys Lys Gly Leu Ala Pro Glu Val Ala 
225                 230                 235                 240 


Asp Arg Ile Gly Asp Tyr Val Gln Cys His Gly Gly Val Ser Leu Val 
                245                 250                 255     


Glu Gln Met Phe Gln Asp Pro Arg Leu Ser Gln Asn Lys Gln Ala Leu 
            260                 265                 270         


Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe 
        275                 280                 285             


Gly Ile Ala Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu 
    290                 295                 300                 


Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro 
305                 310                 315                 320 


Thr Gln Ala Gly Glu Glu Pro Leu Asn Val Gly Ser Val Ala Ala Gly 
                325                 330                 335     


Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly His Lys 
            340                 345                 350         


Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Tyr Ile 
        355                 360                 365             


Val Glu Gln Arg Met Lys Thr Lys Gly Glu Lys Val Arg Thr Thr Glu 
    370                 375                 380                 


Thr Gln Val Phe Val Ala Thr Pro Gln Lys Asn Phe Leu Gln Glu Arg 
385                 390                 395                 400 


Leu Lys Leu Ile Ala Glu Leu Trp Asp Ser Gly Ile Lys Ala Glu Met 
                405                 410                 415     


Leu Tyr Lys Asn Asn Pro Lys Leu Leu Thr Gln Leu His Tyr Cys Glu 
            420                 425                 430         


Ser Thr Gly Ile Pro Leu Val Val Ile Ile Gly Glu Gln Glu Leu Lys 
        435                 440                 445             


Glu Gly Val Ile Lys Ile Arg Ser Val Ala Ser Arg Glu Glu Val Ala 
    450                 455                 460                 


Ile Lys Arg Glu Asn Phe Val Ala Glu Ile Gln Lys Arg Leu Ser Glu 
465                 470                 475                 480 


Ser 
    


<210>  4866
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HARS__Homo_sapiens__NP_001244969

<400>  4866

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Glu Thr Leu Met 
    50                  55                  60                  


Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln 
65                  70                  75                  80  


Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala 
                85                  90                  95      


Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile 
            100                 105                 110         


Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr 
        115                 120                 125             


Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro 
    130                 135                 140                 


Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser 
145                 150                 155                 160 


Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile 
                165                 170                 175     


Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg 
            180                 185                 190         


Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu 
        195                 200                 205             


Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala 
    210                 215                 220                 


Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val 
225                 230                 235                 240 


Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu 
                245                 250                 255     


Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe 
            260                 265                 270         


Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu 
        275                 280                 285             


Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro 
    290                 295                 300                 


Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly 
305                 310                 315                 320 


Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys 
                325                 330                 335     


Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile 
            340                 345                 350         


Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu 
        355                 360                 365             


Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg 
    370                 375                 380                 


Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu 
385                 390                 395                 400 


Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu 
                405                 410                 415     


Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys 
            420                 425                 430         


Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp 
        435                 440                 445             


Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln 
    450                 455                 460                 


Pro Leu Cys Ile Cys 
465                 


<210>  4867
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAS1__Homo_sapiens__NP_001284365

<400>  4867

Met Arg Gln Asp Ala Pro Lys Pro Thr Pro Ala Ala Cys Arg Cys Ser 
1               5                   10                  15      


Gly Leu Ala Arg Arg Val Leu Thr Ile Ala Phe Ala Leu Leu Ile Leu 
            20                  25                  30          


Gly Leu Met Thr Trp Ala Tyr Ala Ala Gly Val Pro Leu Ala Ser Asp 
        35                  40                  45              


Arg Tyr Gly Leu Leu Ala Phe Gly Leu Tyr Gly Ala Phe Leu Ser Ala 
    50                  55                  60                  


His Leu Val Ala Gln Ser Leu Phe Ala Tyr Leu Glu His Arg Arg Val 
65                  70                  75                  80  


Ala Ala Ala Ala Arg Gly Pro Leu Asp Ala Ala Thr Ala Arg Ser Val 
                85                  90                  95      


Ala Leu Thr Ile Ser Ala Tyr Gln Glu Asp Pro Ala Tyr Leu Arg Gln 
            100                 105                 110         


Cys Leu Ala Ser Ala Arg Ala Leu Leu Tyr Pro Arg Ala Arg Leu Arg 
        115                 120                 125             


Val Leu Met Val Val Asp Gly Asn Arg Ala Glu Asp Leu Tyr Met Val 
    130                 135                 140                 


Asp Met Phe Arg Glu Val Phe Ala Asp Glu Asp Pro Ala Thr Tyr Val 
145                 150                 155                 160 


Trp Asp Gly Asn Tyr His Gln Pro Trp Glu Pro Ala Ala Ala Gly Ala 
                165                 170                 175     


Val Gly Ala Gly Ala Tyr Arg Glu Val Glu Ala Glu Asp Pro Gly Arg 
            180                 185                 190         


Leu Ala Val Glu Ala Leu Val Arg Thr Arg Arg Cys Val Cys Val Ala 
        195                 200                 205             


Gln Arg Trp Gly Gly Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala 
    210                 215                 220                 


Leu Gly Asp Ser Val Asp Tyr Val Gln Val Cys Asp Ser Asp Thr Arg 
225                 230                 235                 240 


Leu Asp Pro Met Ala Leu Leu Glu Leu Val Arg Val Leu Asp Glu Asp 
                245                 250                 255     


Pro Arg Val Gly Ala Val Gly Gly Asp Val Arg Ile Leu Asn Pro Leu 
            260                 265                 270         


Asp Ser Trp Val Ser Phe Leu Ser Ser Leu Arg Tyr Trp Val Ala Phe 
        275                 280                 285             


Asn Val Glu Arg Ala Cys Gln Ser Tyr Phe His Cys Val Ser Cys Ile 
    290                 295                 300                 


Ser Gly Pro Leu Gly Leu Tyr Arg Asn Asn Leu Leu Gln Gln Phe Leu 
305                 310                 315                 320 


Glu Ala Trp Tyr Asn Gln Lys Phe Leu Gly Thr His Cys Thr Phe Gly 
                325                 330                 335     


Asp Asp Arg His Leu Thr Asn Arg Met Leu Ser Met Gly Tyr Ala Thr 
            340                 345                 350         


Lys Tyr Thr Ser Arg Ser Arg Cys Tyr Ser Glu Thr Pro Ser Ser Phe 
        355                 360                 365             


Leu Arg Trp Leu Ser Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe Arg 
    370                 375                 380                 


Glu Trp Leu Tyr Asn Ala Leu Trp Trp His Arg His His Ala Trp Met 
385                 390                 395                 400 


Thr Tyr Glu Ala Val Val Ser Gly Leu Phe Pro Phe Phe Val Ala Ala 
                405                 410                 415     


Thr Val Leu Arg Leu Phe Tyr Ala Gly Arg Pro Trp Ala Leu Leu Trp 
            420                 425                 430         


Val Leu Leu Cys Val Gln Gly Val Ala Leu Ala Lys Ala Ala Phe Ala 
        435                 440                 445             


Ala Trp Leu Arg Gly Cys Leu Arg Met Val Leu Leu Ser Leu Tyr Ala 
    450                 455                 460                 


Pro Leu Tyr Met Cys Gly Leu Leu Pro Ala Lys Phe Leu Ala Leu Val 
465                 470                 475                 480 


Thr Met Asn Gln Ser Gly Trp Gly Thr Ser Gly Arg Arg Lys Leu Ala 
                485                 490                 495     


Ala Asn Tyr Val Pro Leu Leu Pro Leu Ala Leu Trp Ala Leu Leu Leu 
            500                 505                 510         


Leu Gly Gly Leu Val Arg Ser Val Ala His Glu Ala Arg Ala Asp Trp 
        515                 520                 525             


Ser Gly Pro Ser Arg Ala Ala Glu Ala Tyr His Leu Ala Ala Gly Ala 
    530                 535                 540                 


Gly Ala Tyr Val Gly Tyr Trp Val Ala Met Leu Thr Leu Tyr Trp Val 
545                 550                 555                 560 


Gly Val Arg Arg Leu Cys Arg Arg Arg Thr Gly Gly Tyr Arg Val Gln 
                565                 570                 575     


Val 
    


<210>  4868
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAS2__Homo_sapiens__XP_011515304

<400>  4868

Met His Cys Glu Arg Phe Leu Cys Ile Leu Arg Ile Ile Gly Thr Thr 
1               5                   10                  15      


Leu Phe Gly Val Ser Leu Leu Leu Gly Ile Thr Ala Ala Tyr Ile Val 
            20                  25                  30          


Gly Tyr Gln Phe Ile Gln Thr Asp Asn Tyr Tyr Phe Ser Phe Gly Leu 
        35                  40                  45              


Tyr Gly Ala Phe Leu Ala Ser His Leu Ile Ile Gln Ser Leu Phe Ala 
    50                  55                  60                  


Phe Leu Glu His Arg Lys Met Lys Lys Ser Leu Glu Thr Pro Ile Lys 
65                  70                  75                  80  


Leu Asn Lys Thr Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu Asp Pro 
                85                  90                  95      


Asp Tyr Leu Arg Lys Cys Leu Gln Ser Val Lys Arg Leu Thr Tyr Pro 
            100                 105                 110         


Gly Ile Lys Val Val Met Val Ile Asp Gly Asn Ser Glu Asp Asp Leu 
        115                 120                 125             


Tyr Met Met Asp Ile Phe Ser Glu Val Met Gly Arg Asp Lys Ser Ala 
    130                 135                 140                 


Thr Tyr Ile Trp Lys Asn Asn Phe His Glu Lys Gly Pro Gly Glu Thr 
145                 150                 155                 160 


Asp Glu Ser His Lys Glu Ser Ser Gln His Val Thr Gln Leu Val Leu 
                165                 170                 175     


Ser Asn Lys Ser Ile Cys Ile Met Gln Lys Trp Gly Gly Lys Arg Glu 
            180                 185                 190         


Val Met Tyr Thr Ala Phe Arg Ala Leu Gly Arg Ser Val Asp Tyr Val 
        195                 200                 205             


Gln Val Cys Asp Ser Asp Thr Met Leu Asp Pro Ala Ser Ser Val Glu 
    210                 215                 220                 


Met Val Lys Val Leu Glu Glu Asp Pro Met Val Gly Gly Val Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser Phe Leu Ser 
                245                 250                 255     


Ser Val Arg Tyr Trp Met Ala Phe Asn Ile Glu Arg Ala Cys Gln Ser 
            260                 265                 270         


Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly Met Tyr Arg 
        275                 280                 285             


Asn Ser Leu Leu His Glu Phe Val Glu Asp Trp Tyr Asn Gln Glu Phe 
    290                 295                 300                 


Met Gly Asn Gln Cys Ser Phe Gly Asp Asp Arg His Leu Thr Asn Arg 
305                 310                 315                 320 


Val Leu Ser Leu Gly Tyr Ala Thr Lys Tyr Thr Ala Arg Ser Lys Cys 
                325                 330                 335     


Leu Thr Glu Thr Pro Ile Glu Tyr Leu Arg Trp Leu Asn Gln Gln Thr 
            340                 345                 350         


Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn Ala Met Trp 
        355                 360                 365             


Phe His Lys His His Leu Trp Met Thr Tyr Glu Ala Ile Ile Thr Gly 
    370                 375                 380                 


Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu Phe Tyr Arg 
385                 390                 395                 400 


Gly Lys Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val Gln Leu Val 
                405                 410                 415     


Gly Leu Ile Lys Ser Ser Phe Ala Ser Cys Leu Arg Gly Asn Ile Val 
            420                 425                 430         


Met Val Phe Met Ser Leu Tyr Ser Val Leu Tyr Met Ser Ser Leu Leu 
        435                 440                 445             


Pro Ala Lys Met Phe Ala Ile Ala Thr Ile Asn Lys Ala Gly Trp Gly 
    450                 455                 460                 


Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly Leu Ile Pro 
465                 470                 475                 480 


Val Ser Val Trp Phe Thr Ile Leu Leu Gly Gly Val Ile Phe Thr Ile 
                485                 490                 495     


Tyr Lys Glu Ser Lys Arg Pro Phe Ser Glu Ser Lys Gln Thr Val Leu 
            500                 505                 510         


Ile Val Gly Thr Leu Leu Tyr Ala Cys Tyr Trp Val Met Leu Leu Thr 
        515                 520                 525             


Leu Tyr Val Val Leu Ile Asn Lys Cys Gly Arg Arg Lys Lys Gly Gln 
    530                 535                 540                 


Gln Tyr Asp Met Val Leu Asp Val 
545                 550         


<210>  4869
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAS3__Homo_sapiens__NP_005320

<400>  4869

Met Pro Val Gln Leu Thr Thr Ala Leu Arg Val Val Gly Thr Ser Leu 
1               5                   10                  15      


Phe Ala Leu Ala Val Leu Gly Gly Ile Leu Ala Ala Tyr Val Thr Gly 
            20                  25                  30          


Tyr Gln Phe Ile His Thr Glu Lys His Tyr Leu Ser Phe Gly Leu Tyr 
        35                  40                  45              


Gly Ala Ile Leu Gly Leu His Leu Leu Ile Gln Ser Leu Phe Ala Phe 
    50                  55                  60                  


Leu Glu His Arg Arg Met Arg Arg Ala Gly Gln Ala Leu Lys Leu Pro 
65                  70                  75                  80  


Ser Pro Arg Arg Gly Ser Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu 
                85                  90                  95      


Asp Pro Asp Tyr Leu Arg Lys Cys Leu Arg Ser Ala Gln Arg Ile Ser 
            100                 105                 110         


Phe Pro Asp Leu Lys Val Val Met Val Val Asp Gly Asn Arg Gln Glu 
        115                 120                 125             


Asp Ala Tyr Met Leu Asp Ile Phe His Glu Val Leu Gly Gly Thr Glu 
    130                 135                 140                 


Gln Ala Gly Phe Phe Val Trp Arg Ser Asn Phe His Glu Ala Gly Glu 
145                 150                 155                 160 


Gly Glu Thr Glu Ala Ser Leu Gln Glu Gly Met Asp Arg Val Arg Asp 
                165                 170                 175     


Val Val Arg Ala Ser Thr Phe Ser Cys Ile Met Gln Lys Trp Gly Gly 
            180                 185                 190         


Lys Arg Glu Val Met Tyr Thr Ala Phe Lys Ala Leu Gly Asp Ser Val 
        195                 200                 205             


Asp Tyr Ile Gln Val Cys Asp Ser Asp Thr Val Leu Asp Pro Ala Cys 
    210                 215                 220                 


Thr Ile Glu Met Leu Arg Val Leu Glu Glu Asp Pro Gln Val Gly Gly 
225                 230                 235                 240 


Val Gly Gly Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser 
                245                 250                 255     


Phe Leu Ser Ser Val Arg Tyr Trp Met Ala Phe Asn Val Glu Arg Ala 
            260                 265                 270         


Cys Gln Ser Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly 
        275                 280                 285             


Met Tyr Arg Asn Ser Leu Leu Gln Gln Phe Leu Glu Asp Trp Tyr His 
    290                 295                 300                 


Gln Lys Phe Leu Gly Ser Lys Cys Ser Phe Gly Asp Asp Arg His Leu 
305                 310                 315                 320 


Thr Asn Arg Val Leu Ser Leu Gly Tyr Arg Thr Lys Tyr Thr Ala Arg 
                325                 330                 335     


Ser Lys Cys Leu Thr Glu Thr Pro Thr Lys Tyr Leu Arg Trp Leu Asn 
            340                 345                 350         


Gln Gln Thr Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn 
        355                 360                 365             


Ser Leu Trp Phe His Lys His His Leu Trp Met Thr Tyr Glu Ser Val 
    370                 375                 380                 


Val Thr Gly Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu 
385                 390                 395                 400 


Phe Tyr Arg Gly Arg Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val 
                405                 410                 415     


Gln Leu Val Gly Ile Ile Lys Ala Thr Tyr Ala Cys Phe Leu Arg Gly 
            420                 425                 430         


Asn Ala Glu Met Ile Phe Met Ser Leu Tyr Ser Leu Leu Tyr Met Ser 
        435                 440                 445             


Ser Leu Leu Pro Ala Lys Ile Phe Ala Ile Ala Thr Ile Asn Lys Ser 
    450                 455                 460                 


Gly Trp Gly Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly 
465                 470                 475                 480 


Leu Ile Pro Val Ser Ile Trp Val Ala Val Leu Leu Gly Gly Leu Ala 
                485                 490                 495     


Tyr Thr Ala Tyr Cys Gln Asp Leu Phe Ser Glu Thr Glu Leu Ala Phe 
            500                 505                 510         


Leu Val Ser Gly Ala Ile Leu Tyr Gly Cys Tyr Trp Val Ala Leu Leu 
        515                 520                 525             


Met Leu Tyr Leu Ala Ile Ile Ala Arg Arg Cys Gly Lys Lys Pro Glu 
    530                 535                 540                 


Gln Tyr Ser Leu Ala Phe Ala Glu Val 
545                 550             


<210>  4870
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAT1__Homo_sapiens__NP_003633

<400>  4870

Met Ala Gly Phe Gly Ala Met Glu Lys Phe Leu Val Glu Tyr Lys Ser 
1               5                   10                  15      


Ala Val Glu Lys Lys Leu Ala Glu Tyr Lys Cys Asn Thr Asn Thr Ala 
            20                  25                  30          


Ile Glu Leu Lys Leu Val Arg Phe Pro Glu Asp Leu Glu Asn Asp Ile 
        35                  40                  45              


Arg Thr Phe Phe Pro Glu Tyr Thr His Gln Leu Phe Gly Asp Asp Glu 
    50                  55                  60                  


Thr Ala Phe Gly Tyr Lys Gly Leu Lys Ile Leu Leu Tyr Tyr Ile Ala 
65                  70                  75                  80  


Gly Ser Leu Ser Thr Met Phe Arg Val Glu Tyr Ala Ser Lys Val Asp 
                85                  90                  95      


Glu Asn Phe Asp Cys Val Glu Ala Asp Asp Val Glu Gly Lys Ile Arg 
            100                 105                 110         


Gln Ile Ile Pro Pro Gly Phe Cys Thr Asn Thr Asn Asp Phe Leu Ser 
        115                 120                 125             


Leu Leu Glu Lys Glu Val Asp Phe Lys Pro Phe Gly Thr Leu Leu His 
    130                 135                 140                 


Thr Tyr Ser Val Leu Ser Pro Thr Gly Gly Glu Asn Phe Thr Phe Gln 
145                 150                 155                 160 


Ile Tyr Lys Ala Asp Met Thr Cys Arg Gly Phe Arg Glu Tyr His Glu 
                165                 170                 175     


Arg Leu Gln Thr Phe Leu Met Trp Phe Ile Glu Thr Ala Ser Phe Ile 
            180                 185                 190         


Asp Val Asp Asp Glu Arg Trp His Tyr Phe Leu Val Phe Glu Lys Tyr 
        195                 200                 205             


Asn Lys Asp Gly Ala Thr Leu Phe Ala Thr Val Gly Tyr Met Thr Val 
    210                 215                 220                 


Tyr Asn Tyr Tyr Val Tyr Pro Asp Lys Thr Arg Pro Arg Val Ser Gln 
225                 230                 235                 240 


Met Leu Ile Leu Thr Pro Phe Gln Gly Gln Gly His Gly Ala Gln Leu 
                245                 250                 255     


Leu Glu Thr Val His Arg Tyr Tyr Thr Glu Phe Pro Thr Val Leu Asp 
            260                 265                 270         


Ile Thr Ala Glu Asp Pro Ser Lys Ser Tyr Val Lys Leu Arg Asp Phe 
        275                 280                 285             


Val Leu Val Lys Leu Cys Gln Asp Leu Pro Cys Phe Ser Arg Glu Lys 
    290                 295                 300                 


Leu Met Gln Gly Phe Asn Glu Asp Met Ala Ile Glu Ala Gln Gln Lys 
305                 310                 315                 320 


Phe Lys Ile Asn Lys Gln His Ala Arg Arg Val Tyr Glu Ile Leu Arg 
                325                 330                 335     


Leu Leu Val Thr Asp Met Ser Asp Ala Glu Gln Tyr Arg Ser Tyr Arg 
            340                 345                 350         


Leu Asp Ile Lys Arg Arg Leu Ile Ser Pro Tyr Lys Lys Lys Gln Arg 
        355                 360                 365             


Asp Leu Ala Lys Met Arg Lys Cys Leu Arg Pro Glu Glu Leu Thr Asn 
    370                 375                 380                 


Gln Met Asn Gln Ile Glu Ile Ser Met Gln His Glu Gln Leu Glu Glu 
385                 390                 395                 400 


Ser Phe Gln Glu Leu Val Glu Asp Tyr Arg Arg Val Ile Glu Arg Leu 
                405                 410                 415     


Ala Gln Glu 
            


<210>  4871
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAVCR1__Homo_sapiens__NP_001166864

<400>  4871

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  4872
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAVCR2__Homo_sapiens__NP_116171

<400>  4872

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  4873
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HAX1__Homo_sapiens__NP_001018238

<400>  4873

Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
            20                  25                  30          


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
        35                  40                  45              


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
    50                  55                  60                  


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
65                  70                  75                  80  


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
                85                  90                  95      


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
            100                 105                 110         


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
        115                 120                 125             


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
    130                 135                 140                 


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
145                 150                 155                 160 


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
                165                 170                 175     


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
            180                 185                 190         


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
        195                 200                 205             


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
    210                 215                 220                 


Gly Arg Trp Phe Arg Ser Arg 
225                 230     


<210>  4874
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBA2__Homo_sapiens__NP_000508

<400>  4874

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  4875
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBB__Homo_sapiens__NP_000509

<400>  4875

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  4876
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBD__Homo_sapiens__NP_000510

<400>  4876

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  4877
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBE1__Homo_sapiens__NP_005321

<400>  4877

Met Val His Phe Thr Ala Glu Glu Lys Ala Ala Val Thr Ser Leu Trp 
1               5                   10                  15      


Ser Lys Met Asn Val Glu Glu Ala Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Pro Ser Ala Ile Leu Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Phe Gly Asp Ala Ile Lys Asn Met Asp 
65                  70                  75                  80  


Asn Leu Lys Pro Ala Phe Ala Lys Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Met Val 
            100                 105                 110         


Ile Ile Leu Ala Thr His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ala Trp Gln Lys Leu Val Ser Ala Val Ala Ile Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  4878
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBEGF__Homo_sapiens__NP_001936

<400>  4878

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210>  4879
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBG1__Homo_sapiens__NP_000550

<400>  4879

Met Gly His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Thr Lys His Leu Asp 
65                  70                  75                  80  


Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ser Trp Gln Lys Met Val Thr Ala Val Ala Ser Ala Leu Ser Ser 
    130                 135                 140                 


Arg Tyr His 
145         


<210>  4880
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBG2__Homo_sapiens__NP_000175

<400>  4880

Met Gly His Phe Thr Glu Glu Asp Lys Ala Thr Ile Thr Ser Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Glu Asp Ala Gly Gly Glu Thr Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Asp Ser Phe Gly Asn 
        35                  40                  45              


Leu Ser Ser Ala Ser Ala Ile Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Thr Ser Leu Gly Asp Ala Ile Lys His Leu Asp 
65                  70                  75                  80  


Asp Leu Lys Gly Thr Phe Ala Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Lys Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Thr Val Leu Ala Ile His Phe Gly Lys Glu Phe Thr Pro Glu Val Gln 
        115                 120                 125             


Ala Ser Trp Gln Lys Met Val Thr Gly Val Ala Ser Ala Leu Ser Ser 
    130                 135                 140                 


Arg Tyr His 
145         


<210>  4881
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBM__Homo_sapiens__NP_001003938

<400>  4881

Met Leu Ser Ala Gln Glu Arg Ala Gln Ile Ala Gln Val Trp Asp Leu 
1               5                   10                  15      


Ile Ala Gly His Glu Ala Gln Phe Gly Ala Glu Leu Leu Leu Arg Leu 
            20                  25                  30          


Phe Thr Val Tyr Pro Ser Thr Lys Val Tyr Phe Pro His Leu Ser Ala 
        35                  40                  45              


Cys Gln Asp Ala Thr Gln Leu Leu Ser His Gly Gln Arg Met Leu Ala 
    50                  55                  60                  


Ala Val Gly Ala Ala Val Gln His Val Asp Asn Leu Arg Ala Ala Leu 
65                  70                  75                  80  


Ser Pro Leu Ala Asp Leu His Ala Leu Val Leu Arg Val Asp Pro Ala 
                85                  90                  95      


Asn Phe Pro Leu Leu Ile Gln Cys Phe His Val Val Leu Ala Ser His 
            100                 105                 110         


Leu Gln Asp Glu Phe Thr Val Gln Met Gln Ala Ala Trp Asp Lys Phe 
        115                 120                 125             


Leu Thr Gly Val Ala Val Val Leu Thr Glu Lys Tyr Arg 
    130                 135                 140     


<210>  4882
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBP1__Homo_sapiens__NP_001231191

<400>  4882

Met Ala Thr Gly Leu Ser Glu His His Asn Met Val Trp Glu Val Lys 
1               5                   10                  15      


Thr Asn Gln Met Pro Asn Ala Val Gln Lys Leu Leu Leu Val Met Asp 
            20                  25                  30          


Lys Arg Ala Ser Gly Met Asn Asp Ser Leu Glu Leu Leu Gln Cys Asn 
        35                  40                  45              


Glu Asn Leu Pro Ser Ser Pro Gly Tyr Asn Ser Cys Asp Glu His Met 
    50                  55                  60                  


Glu Leu Asp Asp Leu Pro Glu Leu Gln Ala Val Gln Ser Asp Pro Thr 
65                  70                  75                  80  


Gln Ser Gly Met Tyr Gln Leu Ser Ser Asp Val Ser His Gln Glu Tyr 
                85                  90                  95      


Pro Arg Ser Ser Trp Asn Gln Asn Thr Ser Asp Ile Pro Glu Thr Thr 
            100                 105                 110         


Tyr Arg Glu Asn Glu Val Asp Trp Leu Thr Glu Leu Ala Asn Ile Ala 
        115                 120                 125             


Thr Ser Pro Gln Ser Pro Leu Met Gln Cys Ser Phe Tyr Asn Arg Ser 
    130                 135                 140                 


Ser Pro Val His Ile Ile Ala Thr Ser Lys Ser Leu His Ser Tyr Ala 
145                 150                 155                 160 


Arg Pro Pro Pro Val Ser Ser Ser Ser Lys Ser Glu Pro Ala Phe Pro 
                165                 170                 175     


His His His Trp Lys Glu Glu Thr Pro Val Arg His Glu Arg Ala Asn 
            180                 185                 190         


Ser Glu Ser Glu Ser Gly Ile Phe Cys Met Ser Ser Leu Ser Asp Asp 
        195                 200                 205             


Asp Asp Leu Gly Trp Cys Asn Ser Trp Pro Ser Thr Val Trp His Cys 
    210                 215                 220                 


Phe Leu Lys Gly Thr Arg Leu Cys Phe His Lys Gly Ser Asn Lys Glu 
225                 230                 235                 240 


Trp Gln Asp Val Glu Asp Phe Ala Arg Ala Glu Gly Cys Asp Asn Glu 
                245                 250                 255     


Glu Asp Leu Gln Met Gly Ile His Lys Gly Tyr Gly Ser Asp Gly Leu 
            260                 265                 270         


Lys Leu Leu Ser His Glu Glu Ser Val Ser Phe Gly Glu Ser Val Leu 
        275                 280                 285             


Lys Leu Thr Phe Asp Pro Gly Thr Val Glu Asp Gly Leu Leu Thr Val 
    290                 295                 300                 


Glu Cys Lys Leu Asp His Pro Phe Tyr Val Lys Asn Lys Gly Trp Ser 
305                 310                 315                 320 


Ser Phe Tyr Pro Ser Leu Thr Val Val Gln His Gly Ile Pro Cys Cys 
                325                 330                 335     


Glu Val His Ile Gly Asp Val Cys Leu Pro Pro Gly His Pro Asp Ala 
            340                 345                 350         


Ile Asn Phe Asp Asp Ser Gly Val Phe Asp Thr Phe Lys Ser Tyr Asp 
        355                 360                 365             


Phe Thr Pro Met Asp Ser Ser Ala Val Tyr Val Leu Ser Ser Met Ala 
    370                 375                 380                 


Arg Gln Arg Arg Ala Ser Leu Ser Cys Gly Gly Pro Gly Gly Gln Asp 
385                 390                 395                 400 


Phe Ala Arg Ser Gly Phe Ser Lys Asn Cys Gly Ser Pro Gly Ser Ser 
                405                 410                 415     


Gln Leu Ser Ser Asn Ser Leu Tyr Ala Lys Ala Val Lys Asn His Ser 
            420                 425                 430         


Ser Gly Thr Val Ser Ala Thr Ser Pro Asn Lys Cys Lys Arg Pro Met 
        435                 440                 445             


Asn Ala Phe Met Leu Phe Ala Lys Lys Tyr Arg Val Glu Tyr Thr Gln 
    450                 455                 460                 


Met Tyr Pro Gly Lys Asp Asn Arg Ala Ile Ser Val Ile Leu Gly Asp 
465                 470                 475                 480 


Arg Trp Lys Lys Met Lys Asn Glu Glu Arg Arg Met Tyr Thr Leu Glu 
                485                 490                 495     


Ala Lys Ala Leu Ala Glu Glu Gln Lys Arg Leu Asn Pro Asp Cys Trp 
            500                 505                 510         


Lys Arg Lys Arg Thr Asn Ser Gly Ser Gln Gln His 
        515                 520                 


<210>  4883
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBQ1__Homo_sapiens__NP_005322

<400>  4883

Met Ala Leu Ser Ala Glu Asp Arg Ala Leu Val Arg Ala Leu Trp Lys 
1               5                   10                  15      


Lys Leu Gly Ser Asn Val Gly Val Tyr Thr Thr Glu Ala Leu Glu Arg 
            20                  25                  30          


Thr Phe Leu Ala Phe Pro Ala Thr Lys Thr Tyr Phe Ser His Leu Asp 
        35                  40                  45              


Leu Ser Pro Gly Ser Ser Gln Val Arg Ala His Gly Gln Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Ser Leu Ala Val Glu Arg Leu Asp Asp Leu Pro His Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser His Leu His Ala Cys Gln Leu Arg Val Asp Pro 
                85                  90                  95      


Ala Ser Phe Gln Leu Leu Gly His Cys Leu Leu Val Thr Leu Ala Arg 
            100                 105                 110         


His Tyr Pro Gly Asp Phe Ser Pro Ala Leu Gln Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ser His Val Ile Ser Ala Leu Val Ser Glu Tyr Arg 
    130                 135                 140         


<210>  4884
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBS1L__Homo_sapiens__NP_001138630

<400>  4884

Met Ala Arg His Arg Asn Val Arg Gly Tyr Asn Tyr Asp Glu Asp Phe 
1               5                   10                  15      


Glu Asp Asp Asp Leu Tyr Gly Gln Ser Val Glu Asp Asp Tyr Cys Ile 
            20                  25                  30          


Ser Pro Ser Thr Ala Arg Leu Tyr Ser Cys Leu Asp His Met Arg Glu 
        35                  40                  45              


Val Leu Gly Asp Ala Val Pro Asp Glu Ile Leu Ile Glu Ala Val Leu 
    50                  55                  60                  


Lys Asn Lys Phe Asp Val Gln Lys Ala Leu Ser Gly Val Leu Glu Gln 
65                  70                  75                  80  


Asp Arg Val Gln Ser Leu Lys Asp Lys Asn Glu Ala Thr Val Ser Thr 
                85                  90                  95      


Gly Lys Ile Ala Lys Gly Lys Pro Val Asp Ser Gln Thr Ser Arg Ser 
            100                 105                 110         


Glu Ser Glu Ile Val Pro Lys Val Ala Lys Met Thr Val Ser Gly Lys 
        115                 120                 125             


Lys Gln Thr Met Gly Phe Glu Val Pro Gly Val Ser Ser Glu Glu Asn 
    130                 135                 140                 


Gly His Ser Phe His Thr Pro Gln Lys Gly Pro Pro Ile Glu Asp Ala 
145                 150                 155                 160 


Ile Ala Ser Ser Asp Val Leu Glu Thr Ala Ser Lys Ser Ala Asn Pro 
                165                 170                 175     


Pro His Thr Ile Gln Ala Ser Glu Glu Gln Ser Ser Thr Pro Ala Pro 
            180                 185                 190         


Val Lys Lys Ser Gly Lys Leu Arg Gln Gln Ile Asp Val Lys Ala Glu 
        195                 200                 205             


Leu Glu Lys Arg Gln Gly Gly Lys Gln Leu Leu Asn Leu Val Val Ile 
    210                 215                 220                 


Gly His Val Asp Ala Gly Lys Ser Thr Leu Met Gly His Met Leu Tyr 
225                 230                 235                 240 


Leu Leu Gly Asn Ile Asn Lys Arg Thr Met His Lys Tyr Glu Gln Glu 
                245                 250                 255     


Ser Lys Lys Ala Gly Lys Ala Ser Phe Ala Tyr Ala Trp Val Leu Asp 
            260                 265                 270         


Glu Thr Gly Glu Glu Arg Glu Arg Gly Val Thr Met Asp Val Gly Met 
        275                 280                 285             


Thr Lys Phe Glu Thr Thr Thr Lys Val Ile Thr Leu Met Asp Ala Pro 
    290                 295                 300                 


Gly His Lys Asp Phe Ile Pro Asn Met Ile Thr Gly Ala Ala Gln Ala 
305                 310                 315                 320 


Asp Val Ala Val Leu Val Val Asp Ala Ser Arg Gly Glu Phe Glu Ala 
                325                 330                 335     


Gly Phe Glu Thr Gly Gly Gln Thr Arg Glu His Gly Leu Leu Val Arg 
            340                 345                 350         


Ser Leu Gly Val Thr Gln Leu Ala Val Ala Val Asn Lys Met Asp Gln 
        355                 360                 365             


Val Asn Trp Gln Gln Glu Arg Phe Gln Glu Ile Thr Gly Lys Leu Gly 
    370                 375                 380                 


His Phe Leu Lys Gln Ala Gly Phe Lys Glu Ser Asp Val Gly Phe Ile 
385                 390                 395                 400 


Pro Thr Ser Gly Leu Ser Gly Glu Asn Leu Ile Thr Arg Ser Gln Ser 
                405                 410                 415     


Ser Glu Leu Thr Lys Trp Tyr Lys Gly Leu Cys Leu Leu Glu Gln Ile 
            420                 425                 430         


Asp Ser Phe Lys Pro Pro Gln Arg Ser Ile Asp Lys Pro Phe Arg Leu 
        435                 440                 445             


Cys Val Ser Asp Val Phe Lys Asp Gln Gly Ser Gly Phe Cys Ile Thr 
    450                 455                 460                 


Gly Lys Ile Glu Ala Gly Tyr Ile Gln Thr Gly Asp Arg Leu Leu Ala 
465                 470                 475                 480 


Met Pro Pro Asn Glu Thr Cys Thr Val Lys Gly Ile Thr Leu His Asp 
                485                 490                 495     


Glu Pro Val Asp Trp Ala Ala Ala Gly Asp His Val Ser Leu Thr Leu 
            500                 505                 510         


Val Gly Met Asp Ile Ile Lys Ile Asn Val Gly Cys Ile Phe Cys Gly 
        515                 520                 525             


Pro Lys Val Pro Ile Lys Ala Cys Thr Arg Phe Arg Ala Arg Ile Leu 
    530                 535                 540                 


Ile Phe Asn Ile Glu Ile Pro Ile Thr Lys Gly Phe Pro Val Leu Leu 
545                 550                 555                 560 


His Tyr Gln Thr Val Ser Glu Pro Ala Val Ile Lys Arg Leu Ile Ser 
                565                 570                 575     


Val Leu Asn Lys Ser Thr Gly Glu Val Thr Lys Lys Lys Pro Lys Phe 
            580                 585                 590         


Leu Thr Lys Gly Gln Asn Ala Leu Val Glu Leu Gln Thr Gln Arg Pro 
        595                 600                 605             


Ile Ala Leu Glu Leu Tyr Lys Asp Phe Lys Glu Leu Gly Arg Phe Met 
    610                 615                 620                 


Leu Arg Tyr Gly Gly Ser Thr Ile Ala Ala Gly Val Val Thr Glu Ile 
625                 630                 635                 640 


Lys Glu 
        


<210>  4885
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBZ__Homo_sapiens__NP_005323

<400>  4885

Met Ser Leu Thr Lys Thr Glu Arg Thr Ile Ile Val Ser Met Trp Ala 
1               5                   10                  15      


Lys Ile Ser Thr Gln Ala Asp Thr Ile Gly Thr Glu Thr Leu Glu Arg 
            20                  25                  30          


Leu Phe Leu Ser His Pro Gln Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu His Pro Gly Ser Ala Gln Leu Arg Ala His Gly Ser Lys Val Val 
    50                  55                  60                  


Ala Ala Val Gly Asp Ala Val Lys Ser Ile Asp Asp Ile Gly Gly Ala 
65                  70                  75                  80  


Leu Ser Lys Leu Ser Glu Leu His Ala Tyr Ile Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


Arg Phe Pro Ala Asp Phe Thr Ala Glu Ala His Ala Ala Trp Asp Lys 
        115                 120                 125             


Phe Leu Ser Val Val Ser Ser Val Leu Thr Glu Lys Tyr Arg 
    130                 135                 140         


<210>  4886
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCAR1__Homo_sapiens__NP_115943

<400>  4886

Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln 
1               5                   10                  15      


Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly 
            20                  25                  30          


Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys 
        35                  40                  45              


Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu 
    50                  55                  60                  


Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His 
65                  70                  75                  80  


Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala 
                85                  90                  95      


Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp 
            100                 105                 110         


Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser 
        115                 120                 125             


Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile 
    130                 135                 140                 


Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu 
145                 150                 155                 160 


Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp 
                165                 170                 175     


His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile 
            180                 185                 190         


Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln 
        195                 200                 205             


Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val 
    210                 215                 220                 


Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg 
225                 230                 235                 240 


Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val 
                245                 250                 255     


His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 
            260                 265                 270         


Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe 
        275                 280                 285             


Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His 
    290                 295                 300                 


Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg 
305                 310                 315                 320 


Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly 
                325                 330                 335     


Gln Trp Asp Pro His Ile Val Glu Trp His 
            340                 345     


<210>  4887
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCAR2__Homo_sapiens__NP_808219

<400>  4887

Met Asn Arg His His Leu Gln Asp His Phe Leu Glu Ile Asp Lys Lys 
1               5                   10                  15      


Asn Cys Cys Val Phe Arg Asp Asp Phe Ile Val Lys Val Leu Pro Pro 
            20                  25                  30          


Val Leu Gly Leu Glu Phe Ile Phe Gly Leu Leu Gly Asn Gly Leu Ala 
        35                  40                  45              


Leu Trp Ile Phe Cys Phe His Leu Lys Ser Trp Lys Ser Ser Arg Ile 
    50                  55                  60                  


Phe Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu Ile Ile Cys Leu 
65                  70                  75                  80  


Pro Phe Leu Met Asp Asn Tyr Val Arg Arg Trp Asp Trp Lys Phe Gly 
                85                  90                  95      


Asp Ile Pro Cys Arg Leu Met Leu Phe Met Leu Ala Met Asn Arg Gln 
            100                 105                 110         


Gly Ser Ile Ile Phe Leu Thr Val Val Ala Val Asp Arg Tyr Phe Arg 
        115                 120                 125             


Val Val His Pro His His Ala Leu Asn Lys Ile Ser Asn Arg Thr Ala 
    130                 135                 140                 


Ala Ile Ile Ser Cys Leu Leu Trp Gly Ile Thr Ile Gly Leu Thr Val 
145                 150                 155                 160 


His Leu Leu Lys Lys Lys Met Pro Ile Gln Asn Gly Gly Ala Asn Leu 
                165                 170                 175     


Cys Ser Ser Phe Ser Ile Cys His Thr Phe Gln Trp His Glu Ala Met 
            180                 185                 190         


Phe Leu Leu Glu Phe Phe Leu Pro Leu Gly Ile Ile Leu Phe Cys Ser 
        195                 200                 205             


Ala Arg Ile Ile Trp Ser Leu Arg Gln Arg Gln Met Asp Arg His Ala 
    210                 215                 220                 


Lys Ile Lys Arg Ala Ile Thr Phe Ile Met Val Val Ala Ile Val Phe 
225                 230                 235                 240 


Val Ile Cys Phe Leu Pro Ser Val Val Val Arg Ile Arg Ile Phe Trp 
                245                 250                 255     


Leu Leu His Thr Ser Gly Thr Gln Asn Cys Glu Val Tyr Arg Ser Val 
            260                 265                 270         


Asp Leu Ala Phe Phe Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 
        275                 280                 285             


Leu Asp Pro Val Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Asn Phe 
    290                 295                 300                 


Phe Ser Thr Leu Ile Asn Arg Cys Leu Gln Arg Lys Met Thr Gly Glu 
305                 310                 315                 320 


Pro Asp Asn Asn Arg Ser Thr Ser Val Glu Leu Thr Gly Asp Pro Asn 
                325                 330                 335     


Lys Thr Arg Gly Ala Pro Glu Ala Leu Met Ala Asn Ser Gly Glu Pro 
            340                 345                 350         


Trp Ser Pro Ser Tyr Leu Gly Pro Thr Ser Pro 
        355                 360             


<210>  4888
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCAR3__Homo_sapiens__NP_006009

<400>  4888

Met Asn Arg His His Leu Gln Asp His Phe Leu Glu Ile Asp Lys Lys 
1               5                   10                  15      


Asn Cys Cys Val Phe Arg Asp Asp Phe Ile Ala Lys Val Leu Pro Pro 
            20                  25                  30          


Val Leu Gly Leu Glu Phe Ile Phe Gly Leu Leu Gly Asn Gly Leu Ala 
        35                  40                  45              


Leu Trp Ile Phe Cys Phe His Leu Lys Ser Trp Lys Ser Ser Arg Ile 
    50                  55                  60                  


Phe Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu Ile Ile Cys Leu 
65                  70                  75                  80  


Pro Phe Val Met Asp Tyr Tyr Val Arg Arg Ser Asp Trp Lys Phe Gly 
                85                  90                  95      


Asp Ile Pro Cys Arg Leu Val Leu Phe Met Phe Ala Met Asn Arg Gln 
            100                 105                 110         


Gly Ser Ile Ile Phe Leu Thr Val Val Ala Val Asp Arg Tyr Phe Arg 
        115                 120                 125             


Val Val His Pro His His Ala Leu Asn Lys Ile Ser Asn Trp Thr Ala 
    130                 135                 140                 


Ala Ile Ile Ser Cys Leu Leu Trp Gly Ile Thr Val Gly Leu Thr Val 
145                 150                 155                 160 


His Leu Leu Lys Lys Lys Leu Leu Ile Gln Asn Gly Thr Ala Asn Val 
                165                 170                 175     


Cys Ile Ser Phe Ser Ile Cys His Thr Phe Arg Trp His Glu Ala Met 
            180                 185                 190         


Phe Leu Leu Glu Phe Phe Leu Pro Leu Gly Ile Ile Leu Phe Cys Ser 
        195                 200                 205             


Ala Arg Ile Ile Trp Ser Leu Arg Gln Arg Gln Met Asp Arg His Ala 
    210                 215                 220                 


Lys Ile Lys Arg Ala Ile Thr Phe Ile Met Val Val Ala Ile Val Phe 
225                 230                 235                 240 


Val Ile Cys Phe Leu Pro Ser Val Val Val Arg Ile His Ile Phe Trp 
                245                 250                 255     


Leu Leu His Thr Ser Gly Thr Gln Asn Cys Glu Val Tyr Arg Ser Val 
            260                 265                 270         


Asp Leu Ala Phe Phe Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 
        275                 280                 285             


Leu Asp Pro Val Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Asn Phe 
    290                 295                 300                 


Phe Ser Thr Leu Ile Asn Arg Cys Leu Gln Arg Lys Ile Thr Gly Glu 
305                 310                 315                 320 


Pro Asp Asn Asn Arg Ser Thr Ser Val Glu Leu Thr Gly Asp Pro Asn 
                325                 330                 335     


Lys Thr Arg Gly Ala Pro Glu Ala Leu Ile Ala Asn Ser Gly Glu Pro 
            340                 345                 350         


Trp Ser Pro Ser Tyr Leu Gly Pro Thr Ser Asn Asn His Ser Lys Lys 
        355                 360                 365             


Gly His Cys His Gln Glu Pro Ala Ser Leu Glu Lys Gln Leu Gly Cys 
    370                 375                 380                 


Cys Ile Glu 
385         


<210>  4889
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCCS__Homo_sapiens__NP_001116080

<400>  4889

Met Gly Leu Ser Pro Ser Ala Pro Ala Val Ala Val Gln Ala Ser Asn 
1               5                   10                  15      


Ala Ser Ala Ser Pro Pro Ser Gly Cys Pro Met His Glu Gly Lys Met 
            20                  25                  30          


Lys Gly Cys Pro Val Asn Thr Glu Pro Ser Gly Pro Thr Cys Glu Lys 
        35                  40                  45              


Lys Thr Tyr Ser Val Pro Ala His Gln Glu Arg Ala Tyr Glu Tyr Val 
    50                  55                  60                  


Glu Cys Pro Ile Arg Gly Thr Ala Ala Glu Asn Lys Glu Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Leu Met Pro Pro Pro Asn Gln Thr Pro Ala Pro Asp Gln 
                85                  90                  95      


Pro Phe Ala Leu Ser Thr Val Arg Glu Glu Ser Ser Ile Pro Arg Ala 
            100                 105                 110         


Asp Ser Glu Lys Lys Trp Val Tyr Pro Ser Glu Gln Met Phe Trp Asn 
        115                 120                 125             


Ala Met Leu Lys Lys Gly Trp Lys Trp Lys Asp Glu Asp Ile Ser Gln 
    130                 135                 140                 


Lys Asp Met Tyr Asn Ile Ile Arg Ile His Asn Gln Asn Asn Glu Gln 
145                 150                 155                 160 


Ala Trp Lys Glu Ile Leu Lys Trp Glu Ala Leu His Ala Ala Glu Cys 
                165                 170                 175     


Pro Cys Gly Pro Ser Leu Ile Arg Phe Gly Gly Lys Ala Lys Glu Tyr 
            180                 185                 190         


Ser Pro Arg Ala Arg Ile Arg Ser Trp Met Gly Tyr Glu Leu Pro Phe 
        195                 200                 205             


Asp Arg His Asp Trp Ile Ile Asn Arg Cys Gly Thr Glu Val Arg Tyr 
    210                 215                 220                 


Val Ile Asp Tyr Tyr Asp Gly Gly Glu Val Asn Lys Asp Tyr Gln Phe 
225                 230                 235                 240 


Thr Ile Leu Asp Val Arg Pro Ala Leu Asp Ser Leu Ser Ala Val Trp 
                245                 250                 255     


Asp Arg Met Lys Val Ala Trp Trp Arg Trp Thr Ser 
            260                 265             


<210>  4890
<211>  2035
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFC1__Homo_sapiens__NP_005325

<400>  4890

Met Ala Ser Ala Val Ser Pro Ala Asn Leu Pro Ala Val Leu Leu Gln 
1               5                   10                  15      


Pro Arg Trp Lys Arg Val Val Gly Trp Ser Gly Pro Val Pro Arg Pro 
            20                  25                  30          


Arg His Gly His Arg Ala Val Ala Ile Lys Glu Leu Ile Val Val Phe 
        35                  40                  45              


Gly Gly Gly Asn Glu Gly Ile Val Asp Glu Leu His Val Tyr Asn Thr 
    50                  55                  60                  


Ala Thr Asn Gln Trp Phe Ile Pro Ala Val Arg Gly Asp Ile Pro Pro 
65                  70                  75                  80  


Gly Cys Ala Ala Tyr Gly Phe Val Cys Asp Gly Thr Arg Leu Leu Val 
                85                  90                  95      


Phe Gly Gly Met Val Glu Tyr Gly Lys Tyr Ser Asn Asp Leu Tyr Glu 
            100                 105                 110         


Leu Gln Ala Ser Arg Trp Glu Trp Lys Arg Leu Lys Ala Lys Thr Pro 
        115                 120                 125             


Lys Asn Gly Pro Pro Pro Cys Pro Arg Leu Gly His Ser Phe Ser Leu 
    130                 135                 140                 


Val Gly Asn Lys Cys Tyr Leu Phe Gly Gly Leu Ala Asn Asp Ser Glu 
145                 150                 155                 160 


Asp Pro Lys Asn Asn Ile Pro Arg Tyr Leu Asn Asp Leu Tyr Ile Leu 
                165                 170                 175     


Glu Leu Arg Pro Gly Ser Gly Val Val Ala Trp Asp Ile Pro Ile Thr 
            180                 185                 190         


Tyr Gly Val Leu Pro Pro Pro Arg Glu Ser His Thr Ala Val Val Tyr 
        195                 200                 205             


Thr Glu Lys Asp Asn Lys Lys Ser Lys Leu Val Ile Tyr Gly Gly Met 
    210                 215                 220                 


Ser Gly Cys Arg Leu Gly Asp Leu Trp Thr Leu Asp Ile Asp Thr Leu 
225                 230                 235                 240 


Thr Trp Asn Lys Pro Ser Leu Ser Gly Val Ala Pro Leu Pro Arg Ser 
                245                 250                 255     


Leu His Ser Ala Thr Thr Ile Gly Asn Lys Met Tyr Val Phe Gly Gly 
            260                 265                 270         


Trp Val Pro Leu Val Met Asp Asp Val Lys Val Ala Thr His Glu Lys 
        275                 280                 285             


Glu Trp Lys Cys Thr Asn Thr Leu Ala Cys Leu Asn Leu Asp Thr Met 
    290                 295                 300                 


Ala Trp Glu Thr Ile Leu Met Asp Thr Leu Glu Asp Asn Ile Pro Arg 
305                 310                 315                 320 


Ala Arg Ala Gly His Cys Ala Val Ala Ile Asn Thr Arg Leu Tyr Ile 
                325                 330                 335     


Trp Ser Gly Arg Asp Gly Tyr Arg Lys Ala Trp Asn Asn Gln Val Cys 
            340                 345                 350         


Cys Lys Asp Leu Trp Tyr Leu Glu Thr Glu Lys Pro Pro Pro Pro Ala 
        355                 360                 365             


Arg Val Gln Leu Val Arg Ala Asn Thr Asn Ser Leu Glu Val Ser Trp 
    370                 375                 380                 


Gly Ala Val Ala Thr Ala Asp Ser Tyr Leu Leu Gln Leu Gln Lys Tyr 
385                 390                 395                 400 


Asp Ile Pro Ala Thr Ala Ala Thr Ala Thr Ser Pro Thr Pro Asn Pro 
                405                 410                 415     


Val Pro Ser Val Pro Ala Asn Pro Pro Lys Ser Pro Ala Pro Ala Ala 
            420                 425                 430         


Ala Ala Pro Ala Val Gln Pro Leu Thr Gln Val Gly Ile Thr Leu Leu 
        435                 440                 445             


Pro Gln Ala Ala Pro Ala Pro Pro Thr Thr Thr Thr Ile Gln Val Leu 
    450                 455                 460                 


Pro Thr Val Pro Gly Ser Ser Ile Ser Val Pro Thr Ala Ala Arg Thr 
465                 470                 475                 480 


Gln Gly Val Pro Ala Val Leu Lys Val Thr Gly Pro Gln Ala Thr Thr 
                485                 490                 495     


Gly Thr Pro Leu Val Thr Met Arg Pro Ala Ser Gln Ala Gly Lys Ala 
            500                 505                 510         


Pro Val Thr Val Thr Ser Leu Pro Ala Gly Val Arg Met Val Val Pro 
        515                 520                 525             


Thr Gln Ser Ala Gln Gly Thr Val Ile Gly Ser Ser Pro Gln Met Ser 
    530                 535                 540                 


Gly Met Ala Ala Leu Ala Ala Ala Ala Ala Ala Thr Gln Lys Ile Pro 
545                 550                 555                 560 


Pro Ser Ser Ala Pro Thr Val Leu Ser Val Pro Ala Gly Thr Thr Ile 
                565                 570                 575     


Val Lys Thr Met Ala Val Thr Pro Gly Thr Thr Thr Leu Pro Ala Thr 
            580                 585                 590         


Val Lys Val Ala Ser Ser Pro Val Met Val Ser Asn Pro Ala Thr Arg 
        595                 600                 605             


Met Leu Lys Thr Ala Ala Ala Gln Val Gly Thr Ser Val Ser Ser Ala 
    610                 615                 620                 


Thr Asn Thr Ser Thr Arg Pro Ile Ile Thr Val His Lys Ser Gly Thr 
625                 630                 635                 640 


Val Thr Val Ala Gln Gln Ala Gln Val Val Thr Thr Val Val Gly Gly 
                645                 650                 655     


Val Thr Lys Thr Ile Thr Leu Val Lys Ser Pro Ile Ser Val Pro Gly 
            660                 665                 670         


Gly Ser Ala Leu Ile Ser Asn Leu Gly Lys Val Met Ser Val Val Gln 
        675                 680                 685             


Thr Lys Pro Val Gln Thr Ser Ala Val Thr Gly Gln Ala Ser Thr Gly 
    690                 695                 700                 


Pro Val Thr Gln Ile Ile Gln Thr Lys Gly Pro Leu Pro Ala Gly Thr 
705                 710                 715                 720 


Ile Leu Lys Leu Val Thr Ser Ala Asp Gly Lys Pro Thr Thr Ile Ile 
                725                 730                 735     


Thr Thr Thr Gln Ala Ser Gly Ala Gly Thr Lys Pro Thr Ile Leu Gly 
            740                 745                 750         


Ile Ser Ser Val Ser Pro Ser Thr Thr Lys Pro Gly Thr Thr Thr Ile 
        755                 760                 765             


Ile Lys Thr Ile Pro Met Ser Ala Ile Ile Thr Gln Ala Gly Ala Thr 
    770                 775                 780                 


Gly Val Thr Ser Ser Pro Gly Ile Lys Ser Pro Ile Thr Ile Ile Thr 
785                 790                 795                 800 


Thr Lys Val Met Thr Ser Gly Thr Gly Ala Pro Ala Lys Ile Ile Thr 
                805                 810                 815     


Ala Val Pro Lys Ile Ala Thr Gly His Gly Gln Gln Gly Val Thr Gln 
            820                 825                 830         


Val Val Leu Lys Gly Ala Pro Gly Gln Pro Gly Thr Ile Leu Arg Thr 
        835                 840                 845             


Val Pro Met Gly Gly Val Arg Leu Val Thr Pro Val Thr Val Ser Ala 
    850                 855                 860                 


Val Lys Pro Ala Val Thr Thr Leu Val Val Lys Gly Thr Thr Gly Val 
865                 870                 875                 880 


Thr Thr Leu Gly Thr Val Thr Gly Thr Val Ser Thr Ser Leu Ala Gly 
                885                 890                 895     


Ala Gly Gly His Ser Thr Ser Ala Ser Leu Ala Thr Pro Ile Thr Thr 
            900                 905                 910         


Leu Gly Thr Ile Ala Thr Leu Ser Ser Gln Val Ile Asn Pro Thr Ala 
        915                 920                 925             


Ile Thr Val Ser Ala Ala Gln Thr Thr Leu Thr Ala Ala Gly Gly Leu 
    930                 935                 940                 


Thr Thr Pro Thr Ile Thr Met Gln Pro Val Ser Gln Pro Thr Gln Val 
945                 950                 955                 960 


Thr Leu Ile Thr Ala Pro Ser Gly Val Glu Ala Gln Pro Val His Asp 
                965                 970                 975     


Leu Pro Val Ser Ile Leu Ala Ser Pro Thr Thr Glu Gln Pro Thr Ala 
            980                 985                 990         


Thr Val Thr Ile Ala Asp Ser Gly  Gln Gly Asp Val Gln  Pro Gly Thr 
        995                 1000                 1005             


Val Thr  Leu Val Cys Ser Asn  Pro Pro Cys Glu Thr  His Glu Thr 
    1010                 1015                 1020             


Gly Thr  Thr Asn Thr Ala Thr  Thr Thr Val Val Ala  Asn Leu Gly 
    1025                 1030                 1035             


Gly His  Pro Gln Pro Thr Gln  Val Gln Phe Val Cys  Asp Arg Gln 
    1040                 1045                 1050             


Glu Ala  Ala Ala Ser Leu Val  Thr Ser Thr Val Gly  Gln Gln Asn 
    1055                 1060                 1065             


Gly Ser  Val Val Arg Val Cys  Ser Asn Pro Pro Cys  Glu Thr His 
    1070                 1075                 1080             


Glu Thr  Gly Thr Thr Asn Thr  Ala Thr Thr Ala Thr  Ser Asn Met 
    1085                 1090                 1095             


Ala Gly  Gln His Gly Cys Ser  Asn Pro Pro Cys Glu  Thr His Glu 
    1100                 1105                 1110             


Thr Gly  Thr Thr Asn Thr Ala  Thr Thr Ala Met Ser  Ser Val Gly 
    1115                 1120                 1125             


Ala Asn  His Gln Arg Asp Ala  Arg Arg Ala Cys Ala  Ala Gly Thr 
    1130                 1135                 1140             


Pro Ala  Val Ile Arg Ile Ser  Val Ala Thr Gly Ala  Leu Glu Ala 
    1145                 1150                 1155             


Ala Gln  Gly Ser Lys Ser Gln  Cys Gln Thr Arg Gln  Thr Ser Ala 
    1160                 1165                 1170             


Thr Ser  Thr Thr Met Thr Val  Met Ala Thr Gly Ala  Pro Cys Ser 
    1175                 1180                 1185             


Ala Gly  Pro Leu Leu Gly Pro  Ser Met Ala Arg Glu  Pro Gly Gly 
    1190                 1195                 1200             


Arg Ser  Pro Ala Phe Val Gln  Leu Ala Pro Leu Ser  Ser Lys Val 
    1205                 1210                 1215             


Arg Leu  Ser Ser Pro Ser Ile  Lys Asp Leu Pro Ala  Gly Arg His 
    1220                 1225                 1230             


Ser His  Ala Val Ser Thr Ala  Ala Met Thr Arg Ser  Ser Val Gly 
    1235                 1240                 1245             


Ala Gly  Glu Pro Arg Met Ala  Pro Val Cys Glu Ser  Leu Gln Gly 
    1250                 1255                 1260             


Gly Ser  Pro Ser Thr Thr Val  Thr Val Thr Ala Leu  Glu Ala Leu 
    1265                 1270                 1275             


Leu Cys  Pro Ser Ala Thr Val  Thr Gln Val Cys Ser  Asn Pro Pro 
    1280                 1285                 1290             


Cys Glu  Thr His Glu Thr Gly  Thr Thr Asn Thr Ala  Thr Thr Ser 
    1295                 1300                 1305             


Asn Ala  Gly Ser Ala Gln Arg  Val Cys Ser Asn Pro  Pro Cys Glu 
    1310                 1315                 1320             


Thr His  Glu Thr Gly Thr Thr  His Thr Ala Thr Thr  Ala Thr Ser 
    1325                 1330                 1335             


Asn Gly  Gly Thr Gly Gln Pro  Glu Gly Gly Gln Gln  Pro Pro Ala 
    1340                 1345                 1350             


Gly Arg  Pro Cys Glu Thr His  Gln Thr Thr Ser Thr  Gly Thr Thr 
    1355                 1360                 1365             


Met Ser  Val Ser Val Gly Ala  Leu Leu Pro Asp Ala  Thr Ser Ser 
    1370                 1375                 1380             


His Arg  Thr Val Glu Ser Gly  Leu Glu Val Ala Ala  Ala Pro Ser 
    1385                 1390                 1395             


Val Thr  Pro Gln Ala Gly Thr  Ala Leu Leu Ala Pro  Phe Pro Thr 
    1400                 1405                 1410             


Gln Arg  Val Cys Ser Asn Pro  Pro Cys Glu Thr His  Glu Thr Gly 
    1415                 1420                 1425             


Thr Thr  His Thr Ala Thr Thr  Val Thr Ser Asn Met  Ser Ser Asn 
    1430                 1435                 1440             


Gln Asp  Pro Pro Pro Ala Ala  Ser Asp Gln Gly Glu  Val Glu Ser 
    1445                 1450                 1455             


Thr Gln  Gly Asp Ser Val Asn  Ile Thr Ser Ser Ser  Ala Ile Thr 
    1460                 1465                 1470             


Thr Thr  Val Ser Ser Thr Leu  Thr Arg Ala Val Thr  Thr Val Thr 
    1475                 1480                 1485             


Gln Ser  Thr Pro Val Pro Gly  Pro Ser Val Pro Pro  Pro Glu Glu 
    1490                 1495                 1500             


Leu Gln  Val Ser Pro Gly Pro  Arg Gln Gln Leu Pro  Pro Arg Gln 
    1505                 1510                 1515             


Leu Leu  Gln Ser Ala Ser Thr  Ala Leu Met Gly Glu  Ser Ala Glu 
    1520                 1525                 1530             


Val Leu  Ser Ala Ser Gln Thr  Pro Glu Leu Pro Ala  Ala Val Asp 
    1535                 1540                 1545             


Leu Ser  Ser Thr Gly Glu Pro  Ser Ser Gly Gln Glu  Ser Ala Gly 
    1550                 1555                 1560             


Ser Ala  Val Val Ala Thr Val  Val Val Gln Pro Pro  Pro Pro Thr 
    1565                 1570                 1575             


Gln Ser  Glu Val Asp Gln Leu  Ser Leu Pro Gln Glu  Leu Met Ala 
    1580                 1585                 1590             


Glu Ala  Gln Ala Gly Thr Thr  Thr Leu Met Val Thr  Gly Leu Thr 
    1595                 1600                 1605             


Pro Glu  Glu Leu Ala Val Thr  Ala Ala Ala Glu Ala  Ala Ala Gln 
    1610                 1615                 1620             


Ala Ala  Ala Thr Glu Glu Ala  Gln Ala Leu Ala Ile  Gln Ala Val 
    1625                 1630                 1635             


Leu Gln  Ala Ala Gln Gln Ala  Val Met Gly Thr Gly  Glu Pro Met 
    1640                 1645                 1650             


Asp Thr  Ser Glu Ala Ala Ala  Thr Val Thr Gln Ala  Glu Leu Gly 
    1655                 1660                 1665             


His Leu  Ser Ala Glu Gly Gln  Glu Gly Gln Ala Thr  Thr Ile Pro 
    1670                 1675                 1680             


Ile Val  Leu Thr Gln Gln Glu  Leu Ala Ala Leu Val  Gln Gln Gln 
    1685                 1690                 1695             


Gln Leu  Gln Glu Ala Gln Ala  Gln Gln Gln His His  His Leu Pro 
    1700                 1705                 1710             


Thr Glu  Ala Leu Ala Pro Ala  Asp Ser Leu Asn Asp  Pro Ala Ile 
    1715                 1720                 1725             


Glu Ser  Asn Cys Leu Asn Glu  Leu Ala Gly Thr Val  Pro Ser Thr 
    1730                 1735                 1740             


Val Ala  Leu Leu Pro Ser Thr  Ala Thr Glu Ser Leu  Ala Pro Ser 
    1745                 1750                 1755             


Asn Thr  Phe Val Ala Pro Gln  Pro Val Val Val Ala  Ser Pro Ala 
    1760                 1765                 1770             


Lys Leu  Gln Ala Ala Ala Thr  Leu Thr Glu Val Ala  Asn Gly Ile 
    1775                 1780                 1785             


Glu Ser  Leu Gly Val Lys Pro  Asp Leu Pro Pro Pro  Pro Ser Lys 
    1790                 1795                 1800             


Ala Pro  Met Lys Lys Glu Asn  Gln Trp Phe Asp Val  Gly Val Ile 
    1805                 1810                 1815             


Lys Gly  Thr Asn Val Met Val  Thr His Tyr Phe Leu  Pro Pro Asp 
    1820                 1825                 1830             


Asp Ala  Val Pro Ser Asp Asp  Asp Leu Gly Thr Val  Pro Asp Tyr 
    1835                 1840                 1845             


Asn Gln  Leu Lys Lys Gln Glu  Leu Gln Pro Gly Thr  Ala Tyr Lys 
    1850                 1855                 1860             


Phe Arg  Val Ala Gly Ile Asn  Ala Cys Gly Arg Gly  Pro Phe Ser 
    1865                 1870                 1875             


Glu Ile  Ser Ala Phe Lys Thr  Cys Leu Pro Gly Phe  Pro Gly Ala 
    1880                 1885                 1890             


Pro Cys  Ala Ile Lys Ile Ser  Lys Ser Pro Asp Gly  Ala His Leu 
    1895                 1900                 1905             


Thr Trp  Glu Pro Pro Ser Val  Thr Ser Gly Lys Ile  Ile Glu Tyr 
    1910                 1915                 1920             


Ser Val  Tyr Leu Ala Ile Gln  Ser Ser Gln Ala Gly  Gly Glu Leu 
    1925                 1930                 1935             


Lys Ser  Ser Thr Pro Ala Gln  Leu Ala Phe Met Arg  Val Tyr Cys 
    1940                 1945                 1950             


Gly Pro  Ser Pro Ser Cys Leu  Val Gln Ser Ser Ser  Leu Ser Asn 
    1955                 1960                 1965             


Ala His  Ile Asp Tyr Thr Thr  Lys Pro Ala Ile Ile  Phe Arg Ile 
    1970                 1975                 1980             


Ala Ala  Arg Asn Glu Lys Gly  Tyr Gly Pro Ala Thr  Gln Val Arg 
    1985                 1990                 1995             


Trp Leu  Gln Glu Thr Ser Lys  Asp Ser Ser Gly Thr  Lys Pro Ala 
    2000                 2005                 2010             


Asn Lys  Arg Pro Met Ser Ser  Pro Glu Met Lys Ser  Ala Pro Lys 
    2015                 2020                 2025             


Lys Ser  Lys Ala Asp Gly Gln  
    2030                 2035 


<210>  4891
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFC2__Homo_sapiens__NP_037452

<400>  4891

Met Ala Ala Pro Ser Leu Leu Asn Trp Arg Arg Val Ser Ser Phe Thr 
1               5                   10                  15      


Gly Pro Val Pro Arg Ala Arg His Gly His Arg Ala Val Ala Ile Arg 
            20                  25                  30          


Glu Leu Met Ile Ile Phe Gly Gly Gly Asn Glu Gly Ile Ala Asp Glu 
        35                  40                  45              


Leu His Val Tyr Asn Thr Ala Thr Asn Gln Trp Phe Leu Pro Ala Val 
    50                  55                  60                  


Arg Gly Asp Ile Pro Pro Gly Cys Ala Ala His Gly Phe Val Cys Asp 
65                  70                  75                  80  


Gly Thr Arg Ile Leu Val Phe Gly Gly Met Val Glu Tyr Gly Arg Tyr 
                85                  90                  95      


Ser Asn Glu Leu Tyr Glu Leu Gln Ala Ser Arg Trp Leu Trp Lys Lys 
            100                 105                 110         


Val Lys Pro His Pro Pro Pro Ser Gly Leu Pro Pro Cys Pro Arg Leu 
        115                 120                 125             


Gly His Ser Phe Ser Leu Tyr Gly Asn Lys Cys Tyr Leu Phe Gly Gly 
    130                 135                 140                 


Leu Ala Asn Glu Ser Glu Asp Ser Asn Asn Asn Val Pro Arg Tyr Leu 
145                 150                 155                 160 


Asn Asp Phe Tyr Glu Leu Glu Leu Gln His Gly Ser Gly Val Val Gly 
                165                 170                 175     


Trp Ser Ile Pro Val Thr Lys Gly Val Val Pro Ser Pro Arg Glu Ser 
            180                 185                 190         


His Thr Ala Val Ile Tyr Cys Lys Lys Asp Ser Gly Ser Pro Lys Met 
        195                 200                 205             


Tyr Val Phe Gly Gly Met Cys Gly Ala Arg Leu Asp Asp Leu Trp Gln 
    210                 215                 220                 


Leu Asp Leu Glu Thr Met Ser Trp Ser Lys Pro Glu Thr Lys Gly Thr 
225                 230                 235                 240 


Val Pro Leu Pro Arg Ser Leu His Thr Ala Ser Val Ile Gly Asn Lys 
                245                 250                 255     


Met Tyr Ile Phe Gly Gly Trp Val Pro His Lys Gly Glu Asn Thr Glu 
            260                 265                 270         


Thr Ser Pro His Asp Cys Glu Trp Arg Cys Thr Ser Ser Phe Ser Tyr 
        275                 280                 285             


Leu Asn Leu Asp Thr Thr Glu Trp Thr Thr Leu Val Ser Asp Ser Gln 
    290                 295                 300                 


Glu Asp Lys Lys Asn Ser Arg Pro Arg Pro Arg Ala Gly His Cys Ala 
305                 310                 315                 320 


Val Ala Ile Gly Thr Arg Leu Tyr Phe Trp Ser Gly Arg Asp Gly Tyr 
                325                 330                 335     


Lys Lys Ala Leu Asn Ser Gln Val Cys Cys Lys Asp Leu Trp Tyr Leu 
            340                 345                 350         


Asp Thr Glu Lys Pro Pro Ala Pro Ser Gln Val Gln Leu Ile Lys Ala 
        355                 360                 365             


Thr Thr Asn Ser Phe His Val Lys Trp Asp Glu Val Ser Thr Val Glu 
    370                 375                 380                 


Gly Tyr Leu Leu Gln Leu Ser Thr Asp Leu Pro Tyr Gln Ala Ala Ser 
385                 390                 395                 400 


Ser Asp Ser Ser Ala Ala Pro Asn Met Gln Gly Val Arg Met Asp Pro 
                405                 410                 415     


His Arg Gln Gly Ser Asn Asn Ile Val Pro Asn Ser Ile Asn Asp Thr 
            420                 425                 430         


Ile Asn Ser Thr Lys Thr Glu Gln Pro Ala Thr Lys Glu Thr Ser Met 
        435                 440                 445             


Lys Asn Lys Pro Asp Phe Lys Ala Leu Thr Asp Ser Asn Ala Ile Leu 
    450                 455                 460                 


Tyr Pro Ser Leu Ala Ser Asn Ala Ser Asn His Asn Ser His Val Val 
465                 470                 475                 480 


Asp Met Leu Arg Lys Asn Glu Gly Pro His Thr Ser Ala Asn Val Gly 
                485                 490                 495     


Val Leu Ser Ser Cys Leu Asp Val Arg Thr Val Ile Pro Glu Thr Ser 
            500                 505                 510         


Val Ser Ser Thr Val Ser Ser Thr Gln Thr Met Val Thr Gln Gln Thr 
        515                 520                 525             


Ile Lys Thr Glu Ser Ser Ser Thr Asn Gly Ala Val Val Lys Asp Glu 
    530                 535                 540                 


Thr Ser Leu Thr Thr Phe Ser Thr Lys Ser Glu Val Asp Glu Thr Tyr 
545                 550                 555                 560 


Ala Leu Pro Ala Thr Lys Ile Ser Arg Val Glu Thr His Ala Thr Ala 
                565                 570                 575     


Thr Pro Phe Ser Lys Glu Thr Pro Ser Asn Pro Val Ala Thr Val Lys 
            580                 585                 590         


Ala Gly Glu Arg Gln Trp Cys Asp Val Gly Ile Phe Lys Asn Asn Thr 
        595                 600                 605             


Ala Leu Val Ser Gln Phe Tyr Leu Leu Pro Lys Gly Lys Gln Ser Ile 
    610                 615                 620                 


Ser Lys Val Gly Asn Ala Asp Val Pro Asp Tyr Ser Leu Leu Lys Lys 
625                 630                 635                 640 


Gln Asp Leu Val Pro Gly Thr Gly Tyr Arg Phe Arg Val Ala Ala Ile 
                645                 650                 655     


Asn Gly Cys Gly Ile Gly Pro Phe Ser Lys Ile Ser Glu Phe Lys Thr 
            660                 665                 670         


Cys Ile Pro Gly Phe Pro Gly Ala Pro Ser Ala Val Arg Ile Ser Lys 
        675                 680                 685             


Asn Val Glu Gly Ile His Leu Ser Trp Glu Pro Pro Thr Ser Pro Ser 
    690                 695                 700                 


Gly Asn Ile Leu Glu Tyr Ser Ala Tyr Leu Ala Ile Arg Thr Ala Gln 
705                 710                 715                 720 


Ile Gln Asp Asn Pro Ser Gln Leu Val Phe Met Arg Ile Tyr Cys Gly 
                725                 730                 735     


Leu Lys Thr Ser Cys Ile Val Thr Ala Gly Gln Leu Ala Asn Ala His 
            740                 745                 750         


Ile Asp Tyr Thr Ser Arg Pro Ala Ile Val Phe Arg Ile Ser Ala Lys 
        755                 760                 765             


Asn Glu Lys Gly Tyr Gly Pro Ala Thr Gln Val Arg Trp Leu Gln Gly 
    770                 775                 780                 


Asn Asn Lys Lys Ala Pro Leu Asn 
785                 790         


<210>  4892
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCK__Homo_sapiens__NP_001165601

<400>  4892

Met Gly Gly Arg Ser Ser Cys Glu Asp Pro Gly Cys Pro Arg Asp Glu 
1               5                   10                  15      


Glu Arg Ala Pro Arg Met Gly Cys Met Lys Ser Lys Phe Leu Gln Val 
            20                  25                  30          


Gly Gly Asn Thr Phe Ser Lys Thr Glu Thr Ser Ala Ser Pro His Cys 
        35                  40                  45              


Pro Val Tyr Val Pro Asp Pro Thr Ser Thr Ile Lys Pro Gly Pro Asn 
    50                  55                  60                  


Ser His Asn Ser Asn Thr Pro Gly Ile Arg Glu Gly Ser Glu Asp Ile 
65                  70                  75                  80  


Ile Val Val Ala Leu Tyr Asp Tyr Glu Ala Ile His His Glu Asp Leu 
                85                  90                  95      


Ser Phe Gln Lys Gly Asp Gln Met Val Val Leu Glu Glu Ser Gly Glu 
            100                 105                 110         


Trp Trp Lys Ala Arg Ser Leu Ala Thr Arg Lys Glu Gly Tyr Ile Pro 
        115                 120                 125             


Ser Asn Tyr Val Ala Arg Val Asp Ser Leu Glu Thr Glu Glu Trp Phe 
    130                 135                 140                 


Phe Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
145                 150                 155                 160 


Gly Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr Thr Lys 
                165                 170                 175     


Gly Ser Tyr Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln Gly Asp 
            180                 185                 190         


Thr Val Lys His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly Phe Tyr 
        195                 200                 205             


Ile Ser Pro Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val Asp His 
    210                 215                 220                 


Tyr Lys Lys Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val Pro Cys 
225                 230                 235                 240 


Met Ser Ser Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp Glu Ile 
                245                 250                 255     


Pro Arg Glu Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly Gln Phe 
            260                 265                 270         


Gly Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val Ala Val 
        275                 280                 285             


Lys Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu Ala Glu 
    290                 295                 300                 


Ala Asn Val Met Lys Thr Leu Gln His Asp Lys Leu Val Lys Leu His 
305                 310                 315                 320 


Ala Val Val Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe Met Ala 
                325                 330                 335     


Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser Lys Gln 
            340                 345                 350         


Pro Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly Met 
        355                 360                 365             


Ala Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
    370                 375                 380                 


Asn Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp Phe Gly 
385                 390                 395                 400 


Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
                405                 410                 415     


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe Gly Ser 
            420                 425                 430         


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Met Glu 
        435                 440                 445             


Ile Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn Pro Glu 
    450                 455                 460                 


Val Ile Arg Ala Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro Glu Asn 
465                 470                 475                 480 


Cys Pro Glu Glu Leu Tyr Asn Ile Met Met Arg Cys Trp Lys Asn Arg 
                485                 490                 495     


Pro Glu Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu Asp Asp 
            500                 505                 510         


Phe Tyr Thr Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro 
        515                 520                 525 


<210>  4893
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCLS1__Homo_sapiens__NP_005326

<400>  4893

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15      


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30          


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45              


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60                  


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80  


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95      


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110         


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125             


Asp Arg Ala Asp Lys Ser Ala Val Gly Phe Asp Tyr Lys Gly Glu Val 
    130                 135                 140                 


Glu Lys His Thr Ser Gln Lys Asp Tyr Ser Arg Gly Phe Gly Gly Arg 
145                 150                 155                 160 


Tyr Gly Val Glu Lys Asp Lys Trp Asp Lys Ala Ala Leu Gly Tyr Asp 
                165                 170                 175     


Tyr Lys Gly Glu Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ala Lys 
            180                 185                 190         


Gly Phe Gly Gly Gln Tyr Gly Ile Gln Lys Asp Arg Val Asp Lys Ser 
        195                 200                 205             


Ala Val Gly Phe Asn Glu Met Glu Ala Pro Thr Thr Ala Tyr Lys Lys 
    210                 215                 220                 


Thr Thr Pro Ile Glu Ala Ala Ser Ser Gly Thr Arg Gly Leu Lys Ala 
225                 230                 235                 240 


Lys Phe Glu Ser Met Ala Glu Glu Lys Arg Lys Arg Glu Glu Glu Glu 
                245                 250                 255     


Lys Ala Gln Gln Val Ala Arg Arg Gln Gln Glu Arg Lys Ala Val Thr 
            260                 265                 270         


Lys Arg Ser Pro Glu Ala Pro Gln Pro Val Ile Ala Met Glu Glu Pro 
        275                 280                 285             


Ala Val Pro Ala Pro Leu Pro Lys Lys Ile Ser Ser Glu Ala Trp Pro 
    290                 295                 300                 


Pro Val Gly Thr Pro Pro Ser Ser Glu Ser Glu Pro Val Arg Thr Ser 
305                 310                 315                 320 


Arg Glu His Pro Val Pro Leu Leu Pro Ile Arg Gln Thr Leu Pro Glu 
                325                 330                 335     


Asp Asn Glu Glu Pro Pro Ala Leu Pro Pro Arg Thr Leu Glu Gly Leu 
            340                 345                 350         


Gln Val Glu Glu Glu Pro Val Tyr Glu Ala Glu Pro Glu Pro Glu Pro 
        355                 360                 365             


Glu Pro Glu Pro Glu Pro Glu Asn Asp Tyr Glu Asp Val Glu Glu Met 
    370                 375                 380                 


Asp Arg His Glu Gln Glu Asp Glu Pro Glu Gly Asp Tyr Glu Glu Val 
385                 390                 395                 400 


Leu Glu Pro Glu Asp Ser Ser Phe Ser Ser Ala Leu Ala Gly Ser Ser 
                405                 410                 415     


Gly Cys Pro Ala Gly Ala Gly Ala Gly Ala Val Ala Leu Gly Ile Ser 
            420                 425                 430         


Ala Val Ala Leu Tyr Asp Tyr Gln Gly Glu Gly Ser Asp Glu Leu Ser 
        435                 440                 445             


Phe Asp Pro Asp Asp Val Ile Thr Asp Ile Glu Met Val Asp Glu Gly 
    450                 455                 460                 


Trp Trp Arg Gly Arg Cys His Gly His Phe Gly Leu Phe Pro Ala Asn 
465                 470                 475                 480 


Tyr Val Lys Leu Leu Glu 
                485     


<210>  4894
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCN1__Homo_sapiens__NP_066550

<400>  4894

Met Glu Gly Gly Gly Lys Pro Asn Ser Ser Ser Asn Ser Arg Asp Asp 
1               5                   10                  15      


Gly Asn Ser Val Phe Pro Ala Lys Ala Ser Ala Thr Gly Ala Gly Pro 
            20                  25                  30          


Ala Ala Ala Glu Lys Arg Leu Gly Thr Pro Pro Gly Gly Gly Gly Ala 
        35                  40                  45              


Gly Ala Lys Glu His Gly Asn Ser Val Cys Phe Lys Val Asp Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Glu Pro Ala Gly Gly 
65                  70                  75                  80  


Phe Glu Asp Ala Glu Gly Pro Arg Arg Gln Tyr Gly Phe Met Gln Arg 
                85                  90                  95      


Gln Phe Thr Ser Met Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg 
            100                 105                 110         


Met Phe Gly Ser Gln Lys Ala Val Glu Lys Glu Gln Glu Arg Val Lys 
        115                 120                 125             


Thr Ala Gly Phe Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr 
    130                 135                 140                 


Trp Asp Leu Ile Met Leu Ile Met Met Val Gly Asn Leu Val Ile Ile 
145                 150                 155                 160 


Pro Val Gly Ile Thr Phe Phe Thr Glu Gln Thr Thr Thr Pro Trp Ile 
                165                 170                 175     


Ile Phe Asn Val Ala Ser Asp Thr Val Phe Leu Leu Asp Leu Ile Met 
            180                 185                 190         


Asn Phe Arg Thr Gly Thr Val Asn Glu Asp Ser Ser Glu Ile Ile Leu 
        195                 200                 205             


Asp Pro Lys Val Ile Lys Met Asn Tyr Leu Lys Ser Trp Phe Val Val 
    210                 215                 220                 


Asp Phe Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Ile Val Glu 
225                 230                 235                 240 


Lys Gly Met Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile 
                245                 250                 255     


Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser 
            260                 265                 270         


Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr 
        275                 280                 285             


Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met 
    290                 295                 300                 


Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro 
305                 310                 315                 320 


Leu Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Leu Asn Glu Met 
                325                 330                 335     


Val Asn Asp Ser Trp Gly Lys Gln Tyr Ser Tyr Ala Leu Phe Lys Ala 
            340                 345                 350         


Met Ser His Met Leu Cys Ile Gly Tyr Gly Ala Gln Ala Pro Val Ser 
        355                 360                 365             


Met Ser Asp Leu Trp Ile Thr Met Leu Ser Met Ile Val Gly Ala Thr 
    370                 375                 380                 


Cys Tyr Ala Met Phe Val Gly His Ala Thr Ala Leu Ile Gln Ser Leu 
385                 390                 395                 400 


Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu Gln 
                405                 410                 415     


Tyr Met Ser Phe His Lys Leu Pro Ala Asp Met Arg Gln Lys Ile His 
            420                 425                 430         


Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Ile Phe Asp Glu Glu Asn 
        435                 440                 445             


Ile Leu Asn Glu Leu Asn Asp Pro Leu Arg Glu Glu Ile Val Asn Phe 
    450                 455                 460                 


Asn Cys Arg Lys Leu Val Ala Thr Met Pro Leu Phe Ala Asn Ala Asp 
465                 470                 475                 480 


Pro Asn Phe Val Thr Ala Met Leu Ser Lys Leu Arg Phe Glu Val Phe 
                485                 490                 495     


Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Ala Val Gly Lys Lys Met 
            500                 505                 510         


Tyr Phe Ile Gln His Gly Val Ala Gly Val Ile Thr Lys Ser Ser Lys 
        515                 520                 525             


Glu Met Lys Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu Leu 
    530                 535                 540                 


Thr Lys Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys Arg 
545                 550                 555                 560 


Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu Val Leu Glu Glu Tyr 
                565                 570                 575     


Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Ile Asp Arg Leu Asp 
            580                 585                 590         


Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu Gln Lys Phe Gln Lys Asp 
        595                 600                 605             


Leu Asn Thr Gly Val Phe Asn Asn Gln Glu Asn Glu Ile Leu Lys Gln 
    610                 615                 620                 


Ile Val Lys His Asp Arg Glu Met Val Gln Ala Ile Ala Pro Ile Asn 
625                 630                 635                 640 


Tyr Pro Gln Met Thr Thr Leu Asn Ser Thr Ser Ser Thr Thr Thr Pro 
                645                 650                 655     


Thr Ser Arg Met Arg Thr Gln Ser Pro Pro Val Tyr Thr Ala Thr Ser 
            660                 665                 670         


Leu Ser His Ser Asn Leu His Ser Pro Ser Pro Ser Thr Gln Thr Pro 
        675                 680                 685             


Gln Pro Ser Ala Ile Leu Ser Pro Cys Ser Tyr Thr Thr Ala Val Cys 
    690                 695                 700                 


Ser Pro Pro Val Gln Ser Pro Leu Ala Ala Arg Thr Phe His Tyr Ala 
705                 710                 715                 720 


Ser Pro Thr Ala Ser Gln Leu Ser Leu Met Gln Gln Gln Pro Gln Gln 
                725                 730                 735     


Gln Val Gln Gln Ser Gln Pro Pro Gln Thr Gln Pro Gln Gln Pro Ser 
            740                 745                 750         


Pro Gln Pro Gln Thr Pro Gly Ser Ser Thr Pro Lys Asn Glu Val His 
        755                 760                 765             


Lys Ser Thr Gln Ala Leu His Asn Thr Asn Leu Thr Arg Glu Val Arg 
    770                 775                 780                 


Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Glu Val Ser Thr Leu 
785                 790                 795                 800 


Ile Ser Arg Pro His Pro Thr Val Gly Glu Ser Leu Ala Ser Ile Pro 
                805                 810                 815     


Gln Pro Val Thr Ala Val Pro Gly Thr Gly Leu Gln Ala Gly Gly Arg 
            820                 825                 830         


Ser Thr Val Pro Gln Arg Val Thr Leu Phe Arg Gln Met Ser Ser Gly 
        835                 840                 845             


Ala Ile Pro Pro Asn Arg Gly Val Pro Pro Ala Pro Pro Pro Pro Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Glu Ser Ser Ser Val Leu Asn Thr Asp Pro Asp 
865                 870                 875                 880 


Ala Glu Lys Pro Arg Phe Ala Ser Asn Leu 
                885                 890 


<210>  4895
<211>  889
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCN2__Homo_sapiens__NP_001185

<400>  4895

Met Asp Ala Arg Gly Gly Gly Gly Arg Pro Gly Glu Ser Pro Gly Ala 
1               5                   10                  15      


Thr Pro Ala Pro Gly Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro Gln 
            20                  25                  30          


Gln Gln Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro Pro Gly Pro Gly 
        35                  40                  45              


Pro Ala Pro Pro Gln His Pro Pro Arg Ala Glu Ala Leu Pro Pro Glu 
    50                  55                  60                  


Ala Ala Asp Glu Gly Gly Pro Arg Gly Arg Leu Arg Ser Arg Asp Ser 
65                  70                  75                  80  


Ser Cys Gly Arg Pro Gly Thr Pro Gly Ala Ala Ser Thr Ala Lys Gly 
                85                  90                  95      


Ser Pro Asn Gly Glu Cys Gly Arg Gly Glu Pro Gln Cys Ser Pro Ala 
            100                 105                 110         


Gly Pro Glu Gly Pro Ala Arg Gly Pro Lys Val Ser Phe Ser Cys Arg 
        115                 120                 125             


Gly Ala Ala Ser Gly Pro Ala Pro Gly Pro Gly Pro Ala Glu Glu Ala 
    130                 135                 140                 


Gly Ser Glu Glu Ala Gly Pro Ala Gly Glu Pro Arg Gly Ser Gln Ala 
145                 150                 155                 160 


Ser Phe Met Gln Arg Gln Phe Gly Ala Leu Leu Gln Pro Gly Val Asn 
                165                 170                 175     


Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val Glu Arg Glu 
            180                 185                 190         


Gln Glu Arg Val Lys Ser Ala Gly Ala Trp Ile Ile His Pro Tyr Ser 
        195                 200                 205             


Asp Phe Arg Phe Tyr Trp Asp Phe Thr Met Leu Leu Phe Met Val Gly 
    210                 215                 220                 


Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys Asp Glu Thr 
225                 230                 235                 240 


Thr Ala Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr Phe Phe Leu 
                245                 250                 255     


Met Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Ile Glu Asp Asn 
            260                 265                 270         


Thr Glu Ile Ile Leu Asp Pro Glu Lys Ile Lys Lys Lys Tyr Leu Arg 
        275                 280                 285             


Thr Trp Phe Val Val Asp Phe Val Ser Ser Ile Pro Val Asp Tyr Ile 
    290                 295                 300                 


Phe Leu Ile Val Glu Lys Gly Ile Asp Ser Glu Val Tyr Lys Thr Ala 
305                 310                 315                 320 


Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg 
                325                 330                 335     


Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu 
            340                 345                 350         


Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Met Arg Ile Cys 
        355                 360                 365             


Asn Leu Ile Ser Met Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu 
    370                 375                 380                 


Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Arg Asn Cys Trp Val 
385                 390                 395                 400 


Ser Ile Asn Gly Met Val Asn His Ser Trp Ser Glu Leu Tyr Ser Phe 
                405                 410                 415     


Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly Tyr Gly Arg 
            420                 425                 430         


Gln Ala Pro Glu Ser Met Thr Asp Ile Trp Leu Thr Met Leu Ser Met 
        435                 440                 445             


Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His Ala Thr Ala 
    450                 455                 460                 


Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr 
465                 470                 475                 480 


Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro Ala Asp Phe 
                485                 490                 495     


Arg Gln Lys Ile His Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Met 
            500                 505                 510         


Phe Asp Glu Asp Ser Ile Leu Gly Glu Leu Asn Gly Pro Leu Arg Glu 
        515                 520                 525             


Glu Ile Val Asn Phe Asn Cys Arg Lys Leu Val Ala Ser Met Pro Leu 
    530                 535                 540                 


Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ala Met Leu Thr Lys Leu 
545                 550                 555                 560 


Lys Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Thr 
                565                 570                 575     


Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val Ser Val Leu 
            580                 585                 590         


Thr Lys Gly Asn Lys Glu Met Lys Leu Ser Asp Gly Ser Tyr Phe Gly 
        595                 600                 605             


Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser Val Arg Ala 
    610                 615                 620                 


Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu 
625                 630                 635                 640 


Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala 
                645                 650                 655     


Ile Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu His 
            660                 665                 670         


Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Asn Gln Glu Asn 
        675                 680                 685             


Ala Ile Ile Gln Glu Ile Val Lys Tyr Asp Arg Glu Met Val Gln Gln 
    690                 695                 700                 


Ala Glu Leu Gly Gln Arg Val Gly Leu Phe Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Gln Val Thr Ser Ala Ile Ala Thr Leu Gln Gln Ala Ala Ala Met 
                725                 730                 735     


Ser Phe Cys Pro Gln Val Ala Arg Pro Leu Val Gly Pro Leu Ala Leu 
            740                 745                 750         


Gly Ser Pro Arg Leu Val Arg Arg Pro Pro Pro Gly Pro Ala Pro Ala 
        755                 760                 765             


Ala Ala Ser Pro Gly Pro Pro Pro Pro Ala Ser Pro Pro Gly Ala Pro 
    770                 775                 780                 


Ala Ser Pro Arg Ala Pro Arg Thr Ser Pro Tyr Gly Gly Leu Pro Ala 
785                 790                 795                 800 


Ala Pro Leu Ala Gly Pro Ala Leu Pro Ala Arg Arg Leu Ser Arg Ala 
                805                 810                 815     


Ser Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Gly Ala Pro 
            820                 825                 830         


Gly Pro Ala Ala Ser Thr Arg Pro Ala Ser Ser Ser Thr Pro Arg Leu 
        835                 840                 845             


Gly Pro Thr Pro Ala Ala Arg Ala Ala Ala Pro Ser Pro Asp Arg Arg 
    850                 855                 860                 


Asp Ser Ala Ser Pro Gly Ala Ala Gly Gly Leu Asp Pro Gln Asp Ser 
865                 870                 875                 880 


Ala Arg Ser Arg Leu Ser Ser Asn Leu 
                885                 


<210>  4896
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCN3__Homo_sapiens__NP_065948

<400>  4896

Met Glu Ala Glu Gln Arg Pro Ala Ala Gly Ala Ser Glu Gly Ala Thr 
1               5                   10                  15      


Pro Gly Leu Glu Ala Val Pro Pro Val Ala Pro Pro Pro Ala Thr Ala 
            20                  25                  30          


Ala Ser Gly Pro Ile Pro Lys Ser Gly Pro Glu Pro Lys Arg Arg His 
        35                  40                  45              


Leu Gly Thr Leu Leu Gln Pro Thr Val Asn Lys Phe Ser Leu Arg Val 
    50                  55                  60                  


Phe Gly Ser His Lys Ala Val Glu Ile Glu Gln Glu Arg Val Lys Ser 
65                  70                  75                  80  


Ala Gly Ala Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp 
                85                  90                  95      


Asp Leu Ile Met Leu Leu Leu Met Val Gly Asn Leu Ile Val Leu Pro 
            100                 105                 110         


Val Gly Ile Thr Phe Phe Lys Glu Glu Asn Ser Pro Pro Trp Ile Val 
        115                 120                 125             


Phe Asn Val Leu Ser Asp Thr Phe Phe Leu Leu Asp Leu Val Leu Asn 
    130                 135                 140                 


Phe Arg Thr Gly Ile Val Val Glu Glu Gly Ala Glu Ile Leu Leu Ala 
145                 150                 155                 160 


Pro Arg Ala Ile Arg Thr Arg Tyr Leu Arg Thr Trp Phe Leu Val Asp 
                165                 170                 175     


Leu Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Val Val Glu Leu 
            180                 185                 190         


Glu Pro Arg Leu Asp Ala Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg 
        195                 200                 205             


Ile Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu 
    210                 215                 220                 


Ser Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met 
225                 230                 235                 240 


Thr Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly 
                245                 250                 255     


Met Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val 
            260                 265                 270         


Pro Met Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Ile Asn His 
        275                 280                 285             


Met Val Asn His Ser Trp Gly Arg Gln Tyr Ser His Ala Leu Phe Lys 
    290                 295                 300                 


Ala Met Ser His Met Leu Cys Ile Gly Tyr Gly Gln Gln Ala Pro Val 
305                 310                 315                 320 


Gly Met Pro Asp Val Trp Leu Thr Met Leu Ser Met Ile Val Gly Ala 
                325                 330                 335     


Thr Cys Tyr Ala Met Phe Ile Gly His Ala Thr Ala Leu Ile Gln Ser 
            340                 345                 350         


Leu Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu 
        355                 360                 365             


Gln Tyr Met Ser Phe His Lys Leu Pro Ala Asp Thr Arg Gln Arg Ile 
    370                 375                 380                 


His Glu Tyr Tyr Glu His Arg Tyr Gln Gly Lys Met Phe Asp Glu Glu 
385                 390                 395                 400 


Ser Ile Leu Gly Glu Leu Ser Glu Pro Leu Arg Glu Glu Ile Ile Asn 
                405                 410                 415     


Phe Thr Cys Arg Gly Leu Val Ala His Met Pro Leu Phe Ala His Ala 
            420                 425                 430         


Asp Pro Ser Phe Val Thr Ala Val Leu Thr Lys Leu Arg Phe Glu Val 
        435                 440                 445             


Phe Gln Pro Gly Asp Leu Val Val Arg Glu Gly Ser Val Gly Arg Lys 
    450                 455                 460                 


Met Tyr Phe Ile Gln His Gly Leu Leu Ser Val Leu Ala Arg Gly Ala 
465                 470                 475                 480 


Arg Asp Thr Arg Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu 
                485                 490                 495     


Leu Thr Arg Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys 
            500                 505                 510         


Arg Leu Tyr Ser Leu Ser Val Asp His Phe Asn Ala Val Leu Glu Glu 
        515                 520                 525             


Phe Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Met Asp Arg Leu 
    530                 535                 540                 


Leu Arg Ile Gly Lys Lys Asn Ser Ile Leu Gln Arg Lys Arg Ser Glu 
545                 550                 555                 560 


Pro Ser Pro Gly Ser Ser Gly Gly Ile Met Glu Gln His Leu Val Gln 
                565                 570                 575     


His Asp Arg Asp Met Ala Arg Gly Val Arg Gly Arg Ala Pro Ser Thr 
            580                 585                 590         


Gly Ala Gln Leu Ser Gly Lys Pro Val Leu Trp Glu Pro Leu Val His 
        595                 600                 605             


Ala Pro Leu Gln Ala Ala Ala Val Thr Ser Asn Val Ala Ile Ala Leu 
    610                 615                 620                 


Thr His Gln Arg Gly Pro Leu Pro Leu Ser Pro Asp Ser Pro Ala Thr 
625                 630                 635                 640 


Leu Leu Ala Arg Ser Ala Trp Arg Ser Ala Gly Ser Pro Ala Ser Pro 
                645                 650                 655     


Leu Val Pro Val Arg Ala Gly Pro Trp Ala Ser Thr Ser Arg Leu Pro 
            660                 665                 670         


Ala Pro Pro Ala Arg Thr Leu His Ala Ser Leu Ser Arg Ala Gly Arg 
        675                 680                 685             


Ser Gln Val Ser Leu Leu Gly Pro Pro Pro Gly Gly Gly Gly Arg Arg 
    690                 695                 700                 


Leu Gly Pro Arg Gly Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro 
705                 710                 715                 720 


Gln Arg Ala Thr Gly Asp Gly Ser Pro Gly Arg Lys Gly Ser Gly Ser 
                725                 730                 735     


Glu Arg Leu Pro Pro Ser Gly Leu Leu Ala Lys Pro Pro Arg Thr Ala 
            740                 745                 750         


Gln Pro Pro Arg Pro Pro Val Pro Glu Pro Ala Thr Pro Arg Gly Leu 
        755                 760                 765             


Gln Leu Ser Ala Asn Met 
    770                 


<210>  4897
<211>  1203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCN4__Homo_sapiens__NP_005468

<400>  4897

Met Asp Lys Leu Pro Pro Ser Met Arg Lys Arg Leu Tyr Ser Leu Pro 
1               5                   10                  15      


Gln Gln Val Gly Ala Lys Ala Trp Ile Met Asp Glu Glu Glu Asp Ala 
            20                  25                  30          


Glu Glu Glu Gly Ala Gly Gly Arg Gln Asp Pro Ser Arg Arg Ser Ile 
        35                  40                  45              


Arg Leu Arg Pro Leu Pro Ser Pro Ser Pro Ser Ala Ala Ala Gly Gly 
    50                  55                  60                  


Thr Glu Ser Arg Ser Ser Ala Leu Gly Ala Ala Asp Ser Glu Gly Pro 
65                  70                  75                  80  


Ala Arg Gly Ala Gly Lys Ser Ser Thr Asn Gly Asp Cys Arg Arg Phe 
                85                  90                  95      


Arg Gly Ser Leu Ala Ser Leu Gly Ser Arg Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Thr Gly Ser Gly Ser Ser His Gly His Leu His Asp Ser Ala Glu Glu 
        115                 120                 125             


Arg Arg Leu Ile Ala Glu Gly Asp Ala Ser Pro Gly Glu Asp Arg Thr 
    130                 135                 140                 


Pro Pro Gly Leu Ala Ala Glu Pro Glu Arg Pro Gly Ala Ser Ala Gln 
145                 150                 155                 160 


Pro Ala Ala Ser Pro Pro Pro Pro Gln Gln Pro Pro Gln Pro Ala Ser 
                165                 170                 175     


Ala Ser Cys Glu Gln Pro Ser Val Asp Thr Ala Ile Lys Val Glu Gly 
            180                 185                 190         


Gly Ala Ala Ala Gly Asp Gln Ile Leu Pro Glu Ala Glu Val Arg Leu 
        195                 200                 205             


Gly Gln Ala Gly Phe Met Gln Arg Gln Phe Gly Ala Met Leu Gln Pro 
    210                 215                 220                 


Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val 
225                 230                 235                 240 


Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly Phe Trp Ile Ile His 
                245                 250                 255     


Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu Thr Met Leu Leu Leu 
            260                 265                 270         


Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys 
        275                 280                 285             


Asp Glu Asn Thr Thr Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr 
    290                 295                 300                 


Phe Phe Leu Ile Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Val 
305                 310                 315                 320 


Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Gln Arg Ile Lys Met Lys 
                325                 330                 335     


Tyr Leu Lys Ser Trp Phe Met Val Asp Phe Ile Ser Ser Ile Pro Val 
            340                 345                 350         


Asp Tyr Ile Phe Leu Ile Val Glu Thr Arg Ile Asp Ser Glu Val Tyr 
        355                 360                 365             


Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser 
    370                 375                 380                 


Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln 
385                 390                 395                 400 


Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Val 
                405                 410                 415     


Arg Ile Val Asn Leu Ile Gly Met Met Leu Leu Leu Cys His Trp Asp 
            420                 425                 430         


Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Asp Asp 
        435                 440                 445             


Cys Trp Val Ser Ile Asn Asn Met Val Asn Asn Ser Trp Gly Lys Gln 
    450                 455                 460                 


Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly 
465                 470                 475                 480 


Tyr Gly Arg Gln Ala Pro Val Gly Met Ser Asp Val Trp Leu Thr Met 
                485                 490                 495     


Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His 
            500                 505                 510         


Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln 
        515                 520                 525             


Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro 
    530                 535                 540                 


Pro Asp Thr Arg Gln Arg Ile His Asp Tyr Tyr Glu His Arg Tyr Gln 
545                 550                 555                 560 


Gly Lys Met Phe Asp Glu Glu Ser Ile Leu Gly Glu Leu Ser Glu Pro 
                565                 570                 575     


Leu Arg Glu Glu Ile Ile Asn Phe Asn Cys Arg Lys Leu Val Ala Ser 
            580                 585                 590         


Met Pro Leu Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ser Met Leu 
        595                 600                 605             


Thr Lys Leu Arg Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg 
    610                 615                 620                 


Glu Gly Thr Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Lys Gly Asn Lys Glu Thr Lys Leu Ala Asp Gly Ser 
                645                 650                 655     


Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser 
            660                 665                 670         


Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn 
        675                 680                 685             


Phe Asn Glu Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu 
    690                 695                 700                 


Thr Val Ala Leu Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile 
705                 710                 715                 720 


Leu Leu His Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Tyr 
                725                 730                 735     


Gln Glu Asn Glu Ile Ile Gln Gln Ile Val Gln His Asp Arg Glu Met 
            740                 745                 750         


Ala His Cys Ala His Arg Val Gln Ala Ala Ala Ser Ala Thr Pro Thr 
        755                 760                 765             


Pro Thr Pro Val Ile Trp Thr Pro Leu Ile Gln Ala Pro Leu Gln Ala 
    770                 775                 780                 


Ala Ala Ala Thr Thr Ser Val Ala Ile Ala Leu Thr His His Pro Arg 
785                 790                 795                 800 


Leu Pro Ala Ala Ile Phe Arg Pro Pro Pro Gly Ser Gly Leu Gly Asn 
                805                 810                 815     


Leu Gly Ala Gly Gln Thr Pro Arg His Leu Lys Arg Leu Gln Ser Leu 
            820                 825                 830         


Ile Pro Ser Ala Leu Gly Ser Ala Ser Pro Ala Ser Ser Pro Ser Gln 
        835                 840                 845             


Val Asp Thr Pro Ser Ser Ser Ser Phe His Ile Gln Gln Leu Ala Gly 
    850                 855                 860                 


Phe Ser Ala Pro Ala Gly Leu Ser Pro Leu Leu Pro Ser Ser Ser Ser 
865                 870                 875                 880 


Ser Pro Pro Pro Gly Ala Cys Gly Ser Pro Ser Ala Pro Thr Pro Ser 
                885                 890                 895     


Ala Gly Val Ala Ala Thr Thr Ile Ala Gly Phe Gly His Phe His Lys 
            900                 905                 910         


Ala Leu Gly Gly Ser Leu Ser Ser Ser Asp Ser Pro Leu Leu Thr Pro 
        915                 920                 925             


Leu Gln Pro Gly Ala Arg Ser Pro Gln Ala Ala Gln Pro Ser Pro Ala 
    930                 935                 940                 


Pro Pro Gly Ala Arg Gly Gly Leu Gly Leu Pro Glu His Phe Leu Pro 
945                 950                 955                 960 


Pro Pro Pro Ser Ser Arg Ser Pro Ser Ser Ser Pro Gly Gln Leu Gly 
                965                 970                 975     


Gln Pro Pro Gly Glu Leu Ser Leu Gly Leu Ala Thr Gly Pro Leu Ser 
            980                 985                 990         


Thr Pro Glu Thr Pro Pro Arg Gln  Pro Glu Pro Pro Ser  Leu Val Ala 
        995                 1000                 1005             


Gly Ala  Ser Gly Gly Ala Ser  Pro Val Gly Phe Thr  Pro Arg Gly 
    1010                 1015                 1020             


Gly Leu  Ser Pro Pro Gly His  Ser Pro Gly Pro Pro  Arg Thr Phe 
    1025                 1030                 1035             


Pro Ser  Ala Pro Pro Arg Ala  Ser Gly Ser His Gly  Ser Leu Leu 
    1040                 1045                 1050             


Leu Pro  Pro Ala Ser Ser Pro  Pro Pro Pro Gln Val  Pro Gln Arg 
    1055                 1060                 1065             


Arg Gly  Thr Pro Pro Leu Thr  Pro Gly Arg Leu Thr  Gln Asp Leu 
    1070                 1075                 1080             


Lys Leu  Ile Ser Ala Ser Gln  Pro Ala Leu Pro Gln  Asp Gly Ala 
    1085                 1090                 1095             


Gln Thr  Leu Arg Arg Ala Ser  Pro His Ser Ser Gly  Glu Ser Met 
    1100                 1105                 1110             


Ala Ala  Phe Pro Leu Phe Pro  Arg Ala Gly Gly Gly  Ser Gly Gly 
    1115                 1120                 1125             


Ser Gly  Ser Ser Gly Gly Leu  Gly Pro Pro Gly Arg  Pro Tyr Gly 
    1130                 1135                 1140             


Ala Ile  Pro Gly Gln His Val  Thr Leu Pro Arg Lys  Thr Ser Ser 
    1145                 1150                 1155             


Gly Ser  Leu Pro Pro Pro Leu  Ser Leu Phe Gly Ala  Arg Ala Thr 
    1160                 1165                 1170             


Ser Ser  Gly Gly Pro Pro Leu  Thr Ala Gly Pro Gln  Arg Glu Pro 
    1175                 1180                 1185             


Gly Ala  Arg Pro Glu Pro Val  Arg Ser Lys Leu Pro  Ser Asn Leu 
    1190                 1195                 1200             


<210>  4898
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCRT__Homo_sapiens__NP_001515

<400>  4898

Met Asn Leu Pro Ser Thr Lys Val Ser Trp Ala Ala Val Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Pro Ala Leu Leu Ser Ser Gly Ala Ala 
            20                  25                  30          


Ala Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg 
        35                  40                  45              


Leu Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu 
    50                  55                  60                  


Thr Leu Gly Lys Arg Arg Ser Gly Pro Pro Gly Leu Gln Gly Arg Leu 
65                  70                  75                  80  


Gln Arg Leu Leu Gln Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr 
                85                  90                  95      


Met Gly Arg Arg Ala Gly Ala Glu Pro Ala Pro Arg Pro Cys Leu Gly 
            100                 105                 110         


Arg Arg Cys Ser Ala Pro Ala Ala Ala Ser Val Ala Pro Gly Gly Gln 
        115                 120                 125             


Ser Gly Ile 
    130     


<210>  4899
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCRTR2__Homo_sapiens__NP_001517

<400>  4899

Met Ser Gly Thr Lys Leu Glu Asp Ser Pro Pro Cys Arg Asn Trp Ser 
1               5                   10                  15      


Ser Ala Ser Glu Leu Asn Glu Thr Gln Glu Pro Phe Leu Asn Pro Thr 
            20                  25                  30          


Asp Tyr Asp Asp Glu Glu Phe Leu Arg Tyr Leu Trp Arg Glu Tyr Leu 
        35                  40                  45              


His Pro Lys Glu Tyr Glu Trp Val Leu Ile Ala Gly Tyr Ile Ile Val 
    50                  55                  60                  


Phe Val Val Ala Leu Ile Gly Asn Val Leu Val Cys Val Ala Val Trp 
65                  70                  75                  80  


Lys Asn His His Met Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu 
                85                  90                  95      


Ser Leu Ala Asp Val Leu Val Thr Ile Thr Cys Leu Pro Ala Thr Leu 
            100                 105                 110         


Val Val Asp Ile Thr Glu Thr Trp Phe Phe Gly Gln Ser Leu Cys Lys 
        115                 120                 125             


Val Ile Pro Tyr Leu Gln Thr Val Ser Val Ser Val Ser Val Leu Thr 
    130                 135                 140                 


Leu Ser Cys Ile Ala Leu Asp Arg Trp Tyr Ala Ile Cys His Pro Leu 
145                 150                 155                 160 


Met Phe Lys Ser Thr Ala Lys Arg Ala Arg Asn Ser Ile Val Ile Ile 
                165                 170                 175     


Trp Ile Val Ser Cys Ile Ile Met Ile Pro Gln Ala Ile Val Met Glu 
            180                 185                 190         


Cys Ser Thr Val Phe Pro Gly Leu Ala Asn Lys Thr Thr Leu Phe Thr 
        195                 200                 205             


Val Cys Asp Glu Arg Trp Gly Gly Glu Ile Tyr Pro Lys Met Tyr His 
    210                 215                 220                 


Ile Cys Phe Phe Leu Val Thr Tyr Met Ala Pro Leu Cys Leu Met Val 
225                 230                 235                 240 


Leu Ala Tyr Leu Gln Ile Phe Arg Lys Leu Trp Cys Arg Gln Ile Pro 
                245                 250                 255     


Gly Thr Ser Ser Val Val Gln Arg Lys Trp Lys Pro Leu Gln Pro Val 
            260                 265                 270         


Ser Gln Pro Arg Gly Pro Gly Gln Pro Thr Lys Ser Arg Met Ser Ala 
        275                 280                 285             


Val Ala Ala Glu Ile Lys Gln Ile Arg Ala Arg Arg Lys Thr Ala Arg 
    290                 295                 300                 


Met Leu Met Ile Val Leu Leu Val Phe Ala Ile Cys Tyr Leu Pro Ile 
305                 310                 315                 320 


Ser Ile Leu Asn Val Leu Lys Arg Val Phe Gly Met Phe Ala His Thr 
                325                 330                 335     


Glu Asp Arg Glu Thr Val Tyr Ala Trp Phe Thr Phe Ser His Trp Leu 
            340                 345                 350         


Val Tyr Ala Asn Ser Ala Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser 
        355                 360                 365             


Gly Lys Phe Arg Glu Glu Phe Lys Ala Ala Phe Ser Cys Cys Cys Leu 
    370                 375                 380                 


Gly Val His His Arg Gln Glu Asp Arg Leu Thr Arg Gly Arg Thr Ser 
385                 390                 395                 400 


Thr Glu Ser Arg Lys Ser Leu Thr Thr Gln Ile Ser Asn Phe Asp Asn 
                405                 410                 415     


Ile Ser Lys Leu Ser Glu Gln Val Val Leu Thr Ser Ile Ser Thr Leu 
            420                 425                 430         


Pro Ala Ala Asn Gly Ala Gly Pro Leu Gln Asn Trp 
        435                 440                 


<210>  4900
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCST__Homo_sapiens__NP_001007470

<400>  4900

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90          


<210>  4901
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC10__Homo_sapiens__NP_001152758

<400>  4901

Met Gly Thr Ala Leu Val Tyr His Glu Asp Met Thr Ala Thr Arg Leu 
1               5                   10                  15      


Leu Trp Asp Asp Pro Glu Cys Glu Ile Glu Arg Pro Glu Arg Leu Thr 
            20                  25                  30          


Ala Ala Leu Asp Arg Leu Arg Gln Arg Gly Leu Glu Gln Arg Cys Leu 
        35                  40                  45              


Arg Leu Ser Ala Arg Glu Ala Ser Glu Glu Glu Leu Gly Leu Val His 
    50                  55                  60                  


Ser Pro Glu Tyr Val Ser Leu Val Arg Glu Thr Gln Val Leu Gly Lys 
65                  70                  75                  80  


Glu Glu Leu Gln Ala Leu Ser Gly Gln Phe Asp Ala Ile Tyr Phe His 
                85                  90                  95      


Pro Ser Thr Phe His Cys Ala Arg Leu Ala Ala Gly Ala Gly Leu Gln 
            100                 105                 110         


Leu Val Asp Ala Val Leu Thr Gly Ala Val Gln Asn Gly Leu Ala Leu 
        115                 120                 125             


Val Arg Pro Pro Gly His His Gly Gln Arg Ala Ala Ala Asn Gly Phe 
    130                 135                 140                 


Cys Val Phe Asn Asn Val Ala Ile Ala Ala Ala His Ala Lys Gln Lys 
145                 150                 155                 160 


His Gly Leu His Arg Ile Leu Val Val Asp Trp Asp Val His His Gly 
                165                 170                 175     


Gln Gly Ile Gln Tyr Leu Phe Glu Asp Asp Pro Ser Val Leu Tyr Phe 
            180                 185                 190         


Ser Trp His Arg Tyr Glu His Gly Arg Phe Trp Pro Phe Leu Arg Glu 
        195                 200                 205             


Ser Asp Ala Asp Ala Val Gly Arg Gly Gln Gly Leu Gly Phe Thr Val 
    210                 215                 220                 


Asn Leu Pro Trp Asn Gln Val Gly Met Gly Asn Ala Asp Tyr Val Ala 
225                 230                 235                 240 


Ala Phe Leu His Leu Leu Leu Pro Leu Ala Phe Glu Gly Gln Met Gln 
                245                 250                 255     


Ala Thr Pro Glu Cys Phe Ala His Leu Thr Gln Leu Leu Gln Val Leu 
            260                 265                 270         


Ala Gly Gly Arg Val Cys Ala Val Leu Glu Gly Gly Tyr His Leu Glu 
        275                 280                 285             


Ser Leu Ala Glu Ser Val Cys Met Thr Val Gln Thr Leu Leu Gly Asp 
    290                 295                 300                 


Pro Ala Pro Pro Leu Ser Gly Pro Met Ala Pro Cys Gln Ser Ala Leu 
305                 310                 315                 320 


Glu Ser Ile Gln Ser Ala Arg Ala Ala Gln Ala Pro His Trp Lys Ser 
                325                 330                 335     


Leu Gln Gln Gln Asp Val Thr Ala Val Pro Met Ser Pro Ser Ser His 
            340                 345                 350         


Ser Pro Glu Gly Arg Pro Pro Pro Leu Leu Pro Gly Gly Pro Val Cys 
        355                 360                 365             


Lys Ala Ala Ala Ser Ala Pro Ser Ser Leu Leu Asp Gln Pro Cys Leu 
    370                 375                 380                 


Cys Pro Ala Pro Ser Val Arg Thr Ala Val Ala Leu Thr Thr Pro Asp 
385                 390                 395                 400 


Ile Thr Leu Val Leu Pro Pro Asp Val Ile Gln Gln Glu Ala Ser Ala 
                405                 410                 415     


Leu Arg Glu Glu Thr Glu Ala Trp Ala Arg Pro His Glu Ser Leu Ala 
            420                 425                 430         


Arg Glu Glu Ala Leu Thr Ala Leu Gly Lys Leu Leu Tyr Leu Leu Asp 
        435                 440                 445             


Gly Met Leu Asp Gly Gln Val Asn Ser Gly Ile Ala Ala Thr Pro Ala 
    450                 455                 460                 


Ser Ala Ala Ala Ala Thr Leu Asp Val Ala Val Arg Arg Gly Leu Ser 
465                 470                 475                 480 


His Gly Ala Gln Arg Leu Leu Cys Val Ala Leu Gly Gln Leu Asp Arg 
                485                 490                 495     


Pro Pro Asp Leu Ala His Asp Gly Arg Ser Leu Trp Leu Asn Ile Arg 
            500                 505                 510         


Gly Lys Glu Ala Ala Ala Leu Ser Met Phe His Val Ser Thr Pro Leu 
        515                 520                 525             


Pro Val Met Thr Gly Gly Phe Leu Ser Cys Ile Leu Gly Leu Val Leu 
    530                 535                 540                 


Pro Leu Ala Tyr Gly Phe Gln Pro Asp Leu Val Leu Val Ala Leu Gly 
545                 550                 555                 560 


Pro Gly His Gly Leu Gln Gly Pro His Ala Ala Leu Leu Ala Ala Met 
                565                 570                 575     


Leu Arg Gly Leu Ala Gly Gly Arg Val Leu Ala Leu Leu Glu Glu Asn 
            580                 585                 590         


Ser Thr Pro Gln Leu Ala Gly Ile Leu Ala Arg Val Leu Asn Gly Glu 
        595                 600                 605             


Ala Pro Pro Ser Leu Gly Pro Ser Ser Val Ala Ser Pro Glu Asp Val 
    610                 615                 620                 


Gln Ala Leu Met Tyr Leu Arg Gly Gln Leu Glu Pro Gln Trp Lys Met 
625                 630                 635                 640 


Leu Gln Cys His Pro His Leu Val Ala 
                645                 


<210>  4902
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC11__Homo_sapiens__NP_001129513

<400>  4902

Met Gly Leu Glu Lys Leu His Pro Phe Asp Ala Gly Lys Trp Gly Lys 
1               5                   10                  15      


Val Ile Asn Phe Leu Lys Glu Glu Lys Leu Leu Ser Asp Ser Met Leu 
            20                  25                  30          


Val Glu Ala Arg Glu Ala Ser Glu Glu Asp Leu Leu Val Val His Thr 
        35                  40                  45              


Arg Arg Tyr Leu Asn Glu Leu Lys Arg Lys Val Leu Arg Pro Leu Arg 
    50                  55                  60                  


Thr Gln Thr Gly Gly Thr Ile Met Ala Gly Lys Leu Ala Val Glu Arg 
65                  70                  75                  80  


Gly Trp Ala Ile Asn Val Gly Gly Gly Phe His His Cys Ser Ser Asp 
                85                  90                  95      


Arg Gly Gly Gly Phe Cys Ala Tyr Ala Asp Ile Thr Leu Ala Ile Lys 
            100                 105                 110         


Phe Leu Phe Glu Arg Val Glu Gly Ile Ser Arg Ala Thr Ile Ile Asp 
        115                 120                 125             


Leu Asp Ala His Gln Gly Asn Gly His Glu Arg Asp Phe Met Asp Asp 
    130                 135                 140                 


Lys Arg Val Tyr Ile Met Asp Val Tyr Asn Arg His Ile Tyr Pro Gly 
145                 150                 155                 160 


Asp Arg Phe Ala Lys Gln Ala Ile Arg Arg Lys Val Glu Leu Glu Trp 
                165                 170                 175     


Gly Thr Glu Asp Asp Glu Tyr Leu Asp Lys Val Glu Arg Asn Ile Lys 
            180                 185                 190         


Lys Ser Leu Gln Glu His Leu Pro Asp Val Val Val Tyr Asn Ala Gly 
        195                 200                 205             


Thr Asp Ile Leu Glu Gly Asp Arg Leu Gly Gly Leu Ser Ile Ser Pro 
    210                 215                 220                 


Ala Gly Ile Val Lys Arg Asp Glu Leu Val Phe Arg Met Val Arg Gly 
225                 230                 235                 240 


Arg Arg Val Pro Ile Leu Met Val Thr Ser Gly Gly Tyr Gln Lys Arg 
                245                 250                 255     


Thr Ala Arg Ile Ile Ala Asp Ser Ile Leu Asn Leu Phe Gly Leu Gly 
            260                 265                 270         


Leu Ile Gly Pro Glu Ser Pro Ser Val Ser Ala Gln Asn Ser Asp Thr 
        275                 280                 285             


Pro Leu Leu Pro Pro Ala Val Pro 
    290                 295     


<210>  4903
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC1__Homo_sapiens__XP_011539611

<400>  4903

Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly Thr Gly 
1               5                   10                  15      


Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala Val Asn 
            20                  25                  30          


Tyr Pro Leu Arg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala Ile Phe 
        35                  40                  45              


Lys Pro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser Ala Val 
    50                  55                  60                  


Val Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu Gly Cys 
65                  70                  75                  80  


Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe Val Lys 
                85                  90                  95      


Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr Thr Ile 
            100                 105                 110         


Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala Leu Asp 
        115                 120                 125             


Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu Tyr Phe 
    130                 135                 140                 


Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr Asn Gln 
145                 150                 155                 160 


Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys Gln Arg Leu Phe Glu Asn 
                165                 170                 175     


Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala Ile Pro 
            180                 185                 190         


Glu Asp Ala Ile Pro Glu Glu Ser Gly Asp Glu Asp Glu Asp Asp Pro 
        195                 200                 205             


Asp Lys Arg Ile Ser Ile Cys Ser Ser Asp Lys Arg Ile Ala Cys Glu 
    210                 215                 220                 


Glu Glu Phe Ser Asp Ser Glu Glu Glu Gly Glu Gly Gly Arg Lys Asn 
225                 230                 235                 240 


Ser Ser Asn Phe Lys Lys Ala Lys Arg Val Lys Thr Glu Asp Glu Lys 
                245                 250                 255     


Glu Lys Asp Pro Glu Glu Lys Lys Glu Val Thr Glu Glu Glu Lys Thr 
            260                 265                 270         


Lys Glu Glu Lys Pro Glu Ala Lys Gly Val Lys Glu Glu Val Lys Leu 
        275                 280                 285             


Ala 
    


<210>  4904
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC2__Homo_sapiens__NP_001518

<400>  4904

Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr 
1               5                   10                  15      


Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys 
            20                  25                  30          


Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu 
        35                  40                  45              


Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu 
    50                  55                  60                  


Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 
65                  70                  75                  80  


Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn 
                85                  90                  95      


Val Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln 
            100                 105                 110         


Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 
        115                 120                 125             


Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 
    130                 135                 140                 


Lys Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 
145                 150                 155                 160 


Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 
                165                 170                 175     


Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 
            180                 185                 190         


Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly 
        195                 200                 205             


Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala 
    210                 215                 220                 


Val Asn Phe Pro Met Arg Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln 
225                 230                 235                 240 


Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser 
                245                 250                 255     


Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu 
            260                 265                 270         


Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val 
        275                 280                 285             


Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr 
    290                 295                 300                 


Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala 
305                 310                 315                 320 


Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 
                325                 330                 335     


Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr 
            340                 345                 350         


Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 
        355                 360                 365             


Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 
    370                 375                 380                 


Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 
385                 390                 395                 400 


Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 
                405                 410                 415     


Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 
            420                 425                 430         


Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu 
        435                 440                 445             


Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu 
    450                 455                 460                 


Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr 
465                 470                 475                 480 


Lys Ser Glu Gln Leu Ser Asn Pro 
                485             


<210>  4905
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC3__Homo_sapiens__NP_003874

<400>  4905

Met Ala Lys Thr Val Ala Tyr Phe Tyr Asp Pro Asp Val Gly Asn Phe 
1               5                   10                  15      


His Tyr Gly Ala Gly His Pro Met Lys Pro His Arg Leu Ala Leu Thr 
            20                  25                  30          


His Ser Leu Val Leu His Tyr Gly Leu Tyr Lys Lys Met Ile Val Phe 
        35                  40                  45              


Lys Pro Tyr Gln Ala Ser Gln His Asp Met Cys Arg Phe His Ser Glu 
    50                  55                  60                  


Asp Tyr Ile Asp Phe Leu Gln Arg Val Ser Pro Thr Asn Met Gln Gly 
65                  70                  75                  80  


Phe Thr Lys Ser Leu Asn Ala Phe Asn Val Gly Asp Asp Cys Pro Val 
                85                  90                  95      


Phe Pro Gly Leu Phe Glu Phe Cys Ser Arg Tyr Thr Gly Ala Ser Leu 
            100                 105                 110         


Gln Gly Ala Thr Gln Leu Asn Asn Lys Ile Cys Asp Ile Ala Ile Asn 
        115                 120                 125             


Trp Ala Gly Gly Leu His His Ala Lys Lys Phe Glu Ala Ser Gly Phe 
    130                 135                 140                 


Cys Tyr Val Asn Asp Ile Val Ile Gly Ile Leu Glu Leu Leu Lys Tyr 
145                 150                 155                 160 


His Pro Arg Val Leu Tyr Ile Asp Ile Asp Ile His His Gly Asp Gly 
                165                 170                 175     


Val Gln Glu Ala Phe Tyr Leu Thr Asp Arg Val Met Thr Val Ser Phe 
            180                 185                 190         


His Lys Tyr Gly Asn Tyr Phe Phe Pro Gly Thr Gly Asp Met Tyr Glu 
        195                 200                 205             


Val Gly Ala Glu Ser Gly Arg Tyr Tyr Cys Leu Asn Val Pro Leu Arg 
    210                 215                 220                 


Asp Gly Ile Asp Asp Gln Ser Tyr Lys His Leu Phe Gln Pro Val Ile 
225                 230                 235                 240 


Asn Gln Val Val Asp Phe Tyr Gln Pro Thr Cys Ile Val Leu Gln Cys 
                245                 250                 255     


Gly Ala Asp Ser Leu Gly Cys Asp Arg Leu Gly Cys Phe Asn Leu Ser 
            260                 265                 270         


Ile Arg Gly His Gly Glu Cys Val Glu Tyr Val Lys Ser Phe Asn Ile 
        275                 280                 285             


Pro Leu Leu Val Leu Gly Gly Gly Gly Tyr Thr Val Arg Asn Val Ala 
    290                 295                 300                 


Arg Cys Trp Thr Tyr Glu Thr Ser Leu Leu Val Glu Glu Ala Ile Ser 
305                 310                 315                 320 


Glu Glu Leu Pro Tyr Ser Glu Tyr Phe Glu Tyr Phe Ala Pro Asp Phe 
                325                 330                 335     


Thr Leu His Pro Asp Val Ser Thr Arg Ile Glu Asn Gln Asn Ser Arg 
            340                 345                 350         


Gln Tyr Leu Asp Gln Ile Arg Gln Thr Ile Phe Glu Asn Leu Lys Met 
        355                 360                 365             


Leu Asn His Ala Pro Ser Val Gln Ile His Asp Val Pro Ala Asp Leu 
    370                 375                 380                 


Leu Thr Tyr Asp Arg Thr Asp Glu Ala Asp Ala Glu Glu Arg Gly Pro 
385                 390                 395                 400 


Glu Glu Asn Tyr Ser Arg Pro Glu Ala Pro Asn Glu Phe Tyr Asp Gly 
                405                 410                 415     


Asp His Asp Asn Asp Lys Glu Ser Asp Val Glu Ile 
            420                 425             


<210>  4906
<211>  1084
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC4__Homo_sapiens__NP_006028

<400>  4906

Met Ser Ser Gln Ser His Pro Asp Gly Leu Ser Gly Arg Asp Gln Pro 
1               5                   10                  15      


Val Glu Leu Leu Asn Pro Ala Arg Val Asn His Met Pro Ser Thr Val 
            20                  25                  30          


Asp Val Ala Thr Ala Leu Pro Leu Gln Val Ala Pro Ser Ala Val Pro 
        35                  40                  45              


Met Asp Leu Arg Leu Asp His Gln Phe Ser Leu Pro Val Ala Glu Pro 
    50                  55                  60                  


Ala Leu Arg Glu Gln Gln Leu Gln Gln Glu Leu Leu Ala Leu Lys Gln 
65                  70                  75                  80  


Lys Gln Gln Ile Gln Arg Gln Ile Leu Ile Ala Glu Phe Gln Arg Gln 
                85                  90                  95      


His Glu Gln Leu Ser Arg Gln His Glu Ala Gln Leu His Glu His Ile 
            100                 105                 110         


Lys Gln Gln Gln Glu Met Leu Ala Met Lys His Gln Gln Glu Leu Leu 
        115                 120                 125             


Glu His Gln Arg Lys Leu Glu Arg His Arg Gln Glu Gln Glu Leu Glu 
    130                 135                 140                 


Lys Gln His Arg Glu Gln Lys Leu Gln Gln Leu Lys Asn Lys Glu Lys 
145                 150                 155                 160 


Gly Lys Glu Ser Ala Val Ala Ser Thr Glu Val Lys Met Lys Leu Gln 
                165                 170                 175     


Glu Phe Val Leu Asn Lys Lys Lys Ala Leu Ala His Arg Asn Leu Asn 
            180                 185                 190         


His Cys Ile Ser Ser Asp Pro Arg Tyr Trp Tyr Gly Lys Thr Gln His 
        195                 200                 205             


Ser Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly Val Ser Thr Ser 
    210                 215                 220                 


Tyr Asn His Pro Val Leu Gly Met Tyr Asp Ala Lys Asp Asp Phe Pro 
225                 230                 235                 240 


Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu Lys Leu Arg Ser Arg Leu 
                245                 250                 255     


Lys Gln Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys 
            260                 265                 270         


Asp Gly Pro Val Val Thr Ala Leu Lys Lys Arg Pro Leu Asp Val Thr 
        275                 280                 285             


Asp Ser Ala Cys Ser Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn 
    290                 295                 300                 


Asn Ser Ser Gly Ser Val Ser Ala Glu Asn Gly Ile Ala Pro Ala Val 
305                 310                 315                 320 


Pro Ser Ile Pro Ala Glu Thr Ser Leu Ala His Arg Leu Val Ala Arg 
                325                 330                 335     


Glu Gly Ser Ala Ala Pro Leu Pro Leu Tyr Thr Ser Pro Ser Leu Pro 
            340                 345                 350         


Asn Ile Thr Leu Gly Leu Pro Ala Thr Gly Pro Ser Ala Gly Thr Ala 
        355                 360                 365             


Gly Gln Gln Asp Ala Glu Arg Leu Thr Leu Pro Ala Leu Gln Gln Arg 
    370                 375                 380                 


Leu Ser Leu Phe Pro Gly Thr His Leu Thr Pro Tyr Leu Ser Thr Ser 
385                 390                 395                 400 


Pro Leu Glu Arg Asp Gly Gly Ala Ala His Ser Pro Leu Leu Gln His 
                405                 410                 415     


Met Val Leu Leu Glu Gln Pro Pro Ala Gln Ala Pro Leu Val Thr Gly 
            420                 425                 430         


Leu Gly Ala Leu Pro Leu His Ala Gln Ser Leu Val Gly Ala Asp Arg 
        435                 440                 445             


Val Ser Pro Ser Ile His Lys Leu Arg Gln His Arg Pro Leu Gly Arg 
    450                 455                 460                 


Thr Gln Ser Ala Pro Leu Pro Gln Asn Ala Gln Ala Leu Gln His Leu 
465                 470                 475                 480 


Val Ile Gln Gln Gln His Gln Gln Phe Leu Glu Lys His Lys Gln Gln 
                485                 490                 495     


Phe Gln Gln Gln Gln Leu Gln Met Asn Lys Ile Ile Pro Lys Pro Ser 
            500                 505                 510         


Glu Pro Ala Arg Gln Pro Glu Ser His Pro Glu Glu Thr Glu Glu Glu 
        515                 520                 525             


Leu Arg Glu His Gln Ala Leu Leu Asp Glu Pro Tyr Leu Asp Arg Leu 
    530                 535                 540                 


Pro Gly Gln Lys Glu Ala His Ala Gln Ala Gly Val Gln Val Lys Gln 
545                 550                 555                 560 


Glu Pro Ile Glu Ser Asp Glu Glu Glu Ala Glu Pro Pro Arg Glu Val 
                565                 570                 575     


Glu Pro Gly Gln Arg Gln Pro Ser Glu Gln Glu Leu Leu Phe Arg Gln 
            580                 585                 590         


Gln Ala Leu Leu Leu Glu Gln Gln Arg Ile His Gln Leu Arg Asn Tyr 
        595                 600                 605             


Gln Ala Ser Met Glu Ala Ala Gly Ile Pro Val Ser Phe Gly Gly His 
    610                 615                 620                 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ser Ala Thr Phe Pro 
625                 630                 635                 640 


Val Ser Val Gln Glu Pro Pro Thr Lys Pro Arg Phe Thr Thr Gly Leu 
                645                 650                 655     


Val Tyr Asp Thr Leu Met Leu Lys His Gln Cys Thr Cys Gly Ser Ser 
            660                 665                 670         


Ser Ser His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg 
        675                 680                 685             


Leu Gln Glu Thr Gly Leu Arg Gly Lys Cys Glu Cys Ile Arg Gly Arg 
    690                 695                 700                 


Lys Ala Thr Leu Glu Glu Leu Gln Thr Val His Ser Glu Ala His Thr 
705                 710                 715                 720 


Leu Leu Tyr Gly Thr Asn Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys 
                725                 730                 735     


Lys Leu Leu Gly Ser Leu Ala Ser Val Phe Val Arg Leu Pro Cys Gly 
            740                 745                 750         


Gly Val Gly Val Asp Ser Asp Thr Ile Trp Asn Glu Val His Ser Ala 
        755                 760                 765             


Gly Ala Ala Arg Leu Ala Val Gly Cys Val Val Glu Leu Val Phe Lys 
    770                 775                 780                 


Val Ala Thr Gly Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro 
785                 790                 795                 800 


Gly His His Ala Glu Glu Ser Thr Pro Met Gly Phe Cys Tyr Phe Asn 
                805                 810                 815     


Ser Val Ala Val Ala Ala Lys Leu Leu Gln Gln Arg Leu Ser Val Ser 
            820                 825                 830         


Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln 
        835                 840                 845             


Gln Ala Phe Tyr Ser Asp Pro Ser Val Leu Tyr Met Ser Leu His Arg 
    850                 855                 860                 


Tyr Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Asp Glu Val 
865                 870                 875                 880 


Gly Thr Gly Pro Gly Val Gly Phe Asn Val Asn Met Ala Phe Thr Gly 
                885                 890                 895     


Gly Leu Asp Pro Pro Met Gly Asp Ala Glu Tyr Leu Ala Ala Phe Arg 
            900                 905                 910         


Thr Val Val Met Pro Ile Ala Ser Glu Phe Ala Pro Asp Val Val Leu 
        915                 920                 925             


Val Ser Ser Gly Phe Asp Ala Val Glu Gly His Pro Thr Pro Leu Gly 
    930                 935                 940                 


Gly Tyr Asn Leu Ser Ala Arg Cys Phe Gly Tyr Leu Thr Lys Gln Leu 
945                 950                 955                 960 


Met Gly Leu Ala Gly Gly Arg Ile Val Leu Ala Leu Glu Gly Gly His 
                965                 970                 975     


Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu 
            980                 985                 990         


Leu Gly Asn Glu Leu Asp Pro Leu  Pro Glu Lys Val Leu  Gln Gln Arg 
        995                 1000                 1005             


Pro Asn  Ala Asn Ala Val Arg  Ser Met Glu Lys Val  Met Glu Ile 
    1010                 1015                 1020             


His Ser  Lys Tyr Trp Arg Cys  Leu Gln Arg Thr Thr  Ser Thr Ala 
    1025                 1030                 1035             


Gly Arg  Ser Leu Ile Glu Ala  Gln Thr Cys Glu Asn  Glu Glu Ala 
    1040                 1045                 1050             


Glu Thr  Val Thr Ala Met Ala  Ser Leu Ser Val Gly  Val Lys Pro 
    1055                 1060                 1065             


Ala Glu  Lys Arg Pro Asp Glu  Glu Pro Met Glu Glu  Glu Pro Pro 
    1070                 1075                 1080             


Leu 
    


<210>  4907
<211>  1123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC5__Homo_sapiens__XP_005256961

<400>  4907

Met Asn Ser Pro Asn Glu Ser Ala Asp Gly Met Ser Gly Arg Glu Pro 
1               5                   10                  15      


Ser Leu Glu Ile Leu Pro Arg Thr Ser Leu His Ser Ile Pro Val Thr 
            20                  25                  30          


Val Glu Val Lys Pro Val Leu Pro Arg Ala Met Pro Ser Ser Met Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Ser Pro Ser Pro Val Glu Leu Arg Gly Ala Leu 
    50                  55                  60                  


Val Gly Ser Val Asp Pro Thr Leu Arg Glu Gln Gln Leu Gln Gln Glu 
65                  70                  75                  80  


Leu Leu Ala Leu Lys Gln Gln Gln Gln Leu Gln Lys Gln Leu Leu Phe 
                85                  90                  95      


Ala Glu Phe Gln Lys Gln His Asp His Leu Thr Arg Gln His Glu Val 
            100                 105                 110         


Gln Leu Gln Lys His Leu Lys Gln Gln Gln Glu Met Leu Ala Ala Lys 
        115                 120                 125             


Gln Gln Gln Glu Met Leu Ala Ala Lys Arg Gln Gln Glu Leu Glu Gln 
    130                 135                 140                 


Gln Arg Gln Arg Glu Gln Gln Arg Gln Glu Glu Leu Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Glu Gln Gln Leu Leu Ile Leu Arg Asn Lys Glu Lys Ser Lys Glu 
                165                 170                 175     


Ser Ala Ile Ala Ser Thr Glu Val Lys Leu Arg Leu Gln Glu Phe Leu 
            180                 185                 190         


Leu Ser Lys Ser Lys Glu Pro Thr Pro Gly Gly Leu Asn His Ser Leu 
        195                 200                 205             


Pro Gln His Pro Lys Cys Trp Gly Ala His His Ala Ser Leu Asp Gln 
    210                 215                 220                 


Ser Ser Pro Pro Gln Ser Gly Pro Pro Gly Thr Pro Pro Ser Tyr Lys 
225                 230                 235                 240 


Leu Pro Leu Pro Gly Pro Tyr Asp Ser Arg Asp Asp Phe Pro Leu Arg 
                245                 250                 255     


Lys Thr Ala Ser Glu Pro Asn Leu Lys Val Arg Ser Arg Leu Lys Gln 
            260                 265                 270         


Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly 
        275                 280                 285             


Thr Val Ile Ser Thr Phe Lys Lys Arg Ala Val Glu Ile Thr Gly Ala 
    290                 295                 300                 


Gly Pro Gly Ala Ser Ser Val Cys Asn Ser Ala Pro Gly Ser Gly Pro 
305                 310                 315                 320 


Ser Ser Pro Asn Ser Ser His Ser Thr Ile Ala Glu Asn Gly Phe Thr 
                325                 330                 335     


Gly Ser Val Pro Asn Ile Pro Thr Glu Met Leu Pro Gln His Arg Ala 
            340                 345                 350         


Leu Pro Leu Asp Ser Ser Pro Asn Gln Phe Ser Leu Tyr Thr Ser Pro 
        355                 360                 365             


Ser Leu Pro Asn Ile Ser Leu Gly Leu Gln Ala Thr Val Thr Val Thr 
    370                 375                 380                 


Asn Ser His Leu Thr Ala Ser Pro Lys Leu Ser Thr Gln Gln Glu Ala 
385                 390                 395                 400 


Glu Arg Gln Ala Leu Gln Ser Leu Arg Gln Gly Gly Thr Leu Thr Gly 
                405                 410                 415     


Lys Phe Met Ser Thr Ser Ser Ile Pro Gly Cys Leu Leu Gly Val Ala 
            420                 425                 430         


Leu Glu Gly Asp Gly Ser Pro His Gly His Ala Ser Leu Leu Gln His 
        435                 440                 445             


Val Leu Leu Leu Glu Gln Ala Arg Gln Gln Ser Thr Leu Ile Ala Val 
    450                 455                 460                 


Pro Leu His Gly Gln Ser Pro Leu Val Thr Gly Glu Arg Val Ala Thr 
465                 470                 475                 480 


Ser Met Arg Thr Val Gly Lys Leu Pro Arg His Arg Pro Leu Ser Arg 
                485                 490                 495     


Thr Gln Ser Ser Pro Leu Pro Gln Ser Pro Gln Ala Leu Gln Gln Leu 
            500                 505                 510         


Val Met Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Gln 
        515                 520                 525             


Gln Leu Gln Leu Gly Lys Ile Leu Thr Lys Thr Gly Glu Leu Pro Arg 
    530                 535                 540                 


Gln Pro Thr Thr His Pro Glu Glu Thr Glu Glu Glu Leu Thr Glu Gln 
545                 550                 555                 560 


Gln Glu Val Leu Leu Gly Glu Gly Ala Leu Thr Met Pro Arg Glu Gly 
                565                 570                 575     


Ser Thr Glu Ser Glu Ser Thr Gln Glu Asp Leu Glu Glu Glu Asp Glu 
            580                 585                 590         


Glu Asp Asp Gly Glu Glu Glu Glu Asp Cys Ile Gln Val Lys Asp Glu 
        595                 600                 605             


Glu Gly Glu Ser Gly Ala Glu Glu Gly Pro Asp Leu Glu Glu Pro Gly 
    610                 615                 620                 


Ala Gly Tyr Lys Lys Leu Phe Ser Asp Ala Gln Pro Leu Gln Pro Leu 
625                 630                 635                 640 


Gln Val Tyr Gln Ala Pro Leu Ser Leu Ala Thr Val Pro His Gln Ala 
                645                 650                 655     


Leu Gly Arg Thr Gln Ser Ser Pro Ala Ala Pro Gly Gly Met Lys Ser 
            660                 665                 670         


Pro Pro Asp Gln Pro Val Lys His Leu Phe Thr Thr Gly Val Val Tyr 
        675                 680                 685             


Asp Thr Phe Met Leu Lys His Gln Cys Met Cys Gly Asn Thr His Val 
    690                 695                 700                 


His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln 
705                 710                 715                 720 


Glu Thr Gly Leu Leu Ser Lys Cys Glu Arg Ile Arg Gly Arg Lys Ala 
                725                 730                 735     


Thr Leu Asp Glu Ile Gln Thr Val His Ser Glu Tyr His Thr Leu Leu 
            740                 745                 750         


Tyr Gly Thr Ser Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu 
        755                 760                 765             


Leu Gly Pro Ile Ser Gln Lys Met Tyr Ala Val Leu Pro Cys Gly Gly 
    770                 775                 780                 


Ile Gly Val Asp Ser Asp Thr Val Trp Asn Glu Met His Ser Ser Ser 
785                 790                 795                 800 


Ala Val Arg Met Ala Val Gly Cys Leu Leu Glu Leu Ala Phe Lys Val 
                805                 810                 815     


Ala Ala Gly Glu Leu Lys Asn Gly Phe Ala Ile Ile Arg Pro Pro Gly 
            820                 825                 830         


His His Ala Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser 
        835                 840                 845             


Val Ala Ile Thr Ala Lys Leu Leu Gln Gln Lys Leu Asn Val Gly Lys 
    850                 855                 860                 


Val Leu Ile Val Asp Trp Asp Ile His His Gly Asn Gly Thr Gln Gln 
865                 870                 875                 880 


Ala Phe Tyr Asn Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg Tyr 
                885                 890                 895     


Asp Asn Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Glu Glu Val Gly 
            900                 905                 910         


Gly Gly Pro Gly Val Gly Tyr Asn Val Asn Val Ala Trp Thr Gly Gly 
        915                 920                 925             


Val Asp Pro Pro Ile Gly Asp Val Glu Tyr Leu Thr Ala Phe Arg Thr 
    930                 935                 940                 


Val Val Met Pro Ile Ala His Glu Phe Ser Pro Asp Val Val Leu Val 
945                 950                 955                 960 


Ser Ala Gly Phe Asp Ala Val Glu Gly His Leu Ser Pro Leu Gly Gly 
                965                 970                 975     


Tyr Ser Val Thr Ala Arg Cys Phe Gly His Leu Thr Arg Gln Leu Met 
            980                 985                 990         


Thr Leu Ala Gly Gly Arg Val Val  Leu Ala Leu Glu Gly  Gly His Asp 
        995                 1000                 1005             


Leu Thr  Ala Ile Cys Asp Ala  Ser Glu Ala Cys Val  Ser Ala Leu 
    1010                 1015                 1020             


Leu Ser  Val Glu Leu Gln Pro  Leu Asp Glu Ala Val  Leu Gln Gln 
    1025                 1030                 1035             


Lys Pro  Asn Ile Asn Ala Val  Ala Thr Leu Glu Lys  Val Ile Glu 
    1040                 1045                 1050             


Ile Gln  Ser Lys His Trp Ser  Cys Val Gln Lys Phe  Ala Ala Gly 
    1055                 1060                 1065             


Leu Gly  Arg Ser Leu Arg Glu  Ala Gln Ala Gly Glu  Thr Glu Glu 
    1070                 1075                 1080             


Ala Glu  Thr Val Ser Ala Met  Ala Leu Leu Ser Val  Gly Ala Glu 
    1085                 1090                 1095             


Gln Ala  Gln Ala Ala Ala Ala  Arg Glu His Ser Pro  Arg Pro Ala 
    1100                 1105                 1110             


Glu Glu  Pro Met Glu Gln Glu  Pro Ala Leu 
    1115                 1120             


<210>  4908
<211>  1215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC6__Homo_sapiens__NP_006035

<400>  4908

Met Thr Ser Thr Gly Gln Asp Ser Thr Thr Thr Arg Gln Arg Arg Ser 
1               5                   10                  15      


Arg Gln Asn Pro Gln Ser Pro Pro Gln Asp Ser Ser Val Thr Ser Lys 
            20                  25                  30          


Arg Asn Ile Lys Lys Gly Ala Val Pro Arg Ser Ile Pro Asn Leu Ala 
        35                  40                  45              


Glu Val Lys Lys Lys Gly Lys Met Lys Lys Leu Gly Gln Ala Met Glu 
    50                  55                  60                  


Glu Asp Leu Ile Val Gly Leu Gln Gly Met Asp Leu Asn Leu Glu Ala 
65                  70                  75                  80  


Glu Ala Leu Ala Gly Thr Gly Leu Val Leu Asp Glu Gln Leu Asn Glu 
                85                  90                  95      


Phe His Cys Leu Trp Asp Asp Ser Phe Pro Glu Gly Pro Glu Arg Leu 
            100                 105                 110         


His Ala Ile Lys Glu Gln Leu Ile Gln Glu Gly Leu Leu Asp Arg Cys 
        115                 120                 125             


Val Ser Phe Gln Ala Arg Phe Ala Glu Lys Glu Glu Leu Met Leu Val 
    130                 135                 140                 


His Ser Leu Glu Tyr Ile Asp Leu Met Glu Thr Thr Gln Tyr Met Asn 
145                 150                 155                 160 


Glu Gly Glu Leu Arg Val Leu Ala Asp Thr Tyr Asp Ser Val Tyr Leu 
                165                 170                 175     


His Pro Asn Ser Tyr Ser Cys Ala Cys Leu Ala Ser Gly Ser Val Leu 
            180                 185                 190         


Arg Leu Val Asp Ala Val Leu Gly Ala Glu Ile Arg Asn Gly Met Ala 
        195                 200                 205             


Ile Ile Arg Pro Pro Gly His His Ala Gln His Ser Leu Met Asp Gly 
    210                 215                 220                 


Tyr Cys Met Phe Asn His Val Ala Val Ala Ala Arg Tyr Ala Gln Gln 
225                 230                 235                 240 


Lys His Arg Ile Arg Arg Val Leu Ile Val Asp Trp Asp Val His His 
                245                 250                 255     


Gly Gln Gly Thr Gln Phe Thr Phe Asp Gln Asp Pro Ser Val Leu Tyr 
            260                 265                 270         


Phe Ser Ile His Arg Tyr Glu Gln Gly Arg Phe Trp Pro His Leu Lys 
        275                 280                 285             


Ala Ser Asn Trp Ser Thr Thr Gly Phe Gly Gln Gly Gln Gly Tyr Thr 
    290                 295                 300                 


Ile Asn Val Pro Trp Asn Gln Val Gly Met Arg Asp Ala Asp Tyr Ile 
305                 310                 315                 320 


Ala Ala Phe Leu His Val Leu Leu Pro Val Ala Leu Glu Phe Gln Pro 
                325                 330                 335     


Gln Leu Val Leu Val Ala Ala Gly Phe Asp Ala Leu Gln Gly Asp Pro 
            340                 345                 350         


Lys Gly Glu Met Ala Ala Thr Pro Ala Gly Phe Ala Gln Leu Thr His 
        355                 360                 365             


Leu Leu Met Gly Leu Ala Gly Gly Lys Leu Ile Leu Ser Leu Glu Gly 
    370                 375                 380                 


Gly Tyr Asn Leu Arg Ala Leu Ala Glu Gly Val Ser Ala Ser Leu His 
385                 390                 395                 400 


Thr Leu Leu Gly Asp Pro Cys Pro Met Leu Glu Ser Pro Gly Ala Pro 
                405                 410                 415     


Cys Arg Ser Ala Gln Ala Ser Val Ser Cys Ala Leu Glu Ala Leu Glu 
            420                 425                 430         


Pro Phe Trp Glu Val Leu Val Arg Ser Thr Glu Thr Val Glu Arg Asp 
        435                 440                 445             


Asn Met Glu Glu Asp Asn Val Glu Glu Ser Glu Glu Glu Gly Pro Trp 
    450                 455                 460                 


Glu Pro Pro Val Leu Pro Ile Leu Thr Trp Pro Val Leu Gln Ser Arg 
465                 470                 475                 480 


Thr Gly Leu Val Tyr Asp Gln Asn Met Met Asn His Cys Asn Leu Trp 
                485                 490                 495     


Asp Ser His His Pro Glu Val Pro Gln Arg Ile Leu Arg Ile Met Cys 
            500                 505                 510         


Arg Leu Glu Glu Leu Gly Leu Ala Gly Arg Cys Leu Thr Leu Thr Pro 
        515                 520                 525             


Arg Pro Ala Thr Glu Ala Glu Leu Leu Thr Cys His Ser Ala Glu Tyr 
    530                 535                 540                 


Val Gly His Leu Arg Ala Thr Glu Lys Met Lys Thr Arg Glu Leu His 
545                 550                 555                 560 


Arg Glu Ser Ser Asn Phe Asp Ser Ile Tyr Ile Cys Pro Ser Thr Phe 
                565                 570                 575     


Ala Cys Ala Gln Leu Ala Thr Gly Ala Ala Cys Arg Leu Val Glu Ala 
            580                 585                 590         


Val Leu Ser Gly Glu Val Leu Asn Gly Ala Ala Val Val Arg Pro Pro 
        595                 600                 605             


Gly His His Ala Glu Gln Asp Ala Ala Cys Gly Phe Cys Phe Phe Asn 
    610                 615                 620                 


Ser Val Ala Val Ala Ala Arg His Ala Gln Thr Ile Ser Gly His Ala 
625                 630                 635                 640 


Leu Arg Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr 
                645                 650                 655     


Gln His Met Phe Glu Asp Asp Pro Ser Val Leu Tyr Val Ser Leu His 
            660                 665                 670         


Arg Tyr Asp His Gly Thr Phe Phe Pro Met Gly Asp Glu Gly Ala Ser 
        675                 680                 685             


Ser Gln Ile Gly Arg Ala Ala Gly Thr Gly Phe Thr Val Asn Val Ala 
    690                 695                 700                 


Trp Asn Gly Pro Arg Met Gly Asp Ala Asp Tyr Leu Ala Ala Trp His 
705                 710                 715                 720 


Arg Leu Val Leu Pro Ile Ala Tyr Glu Phe Asn Pro Glu Leu Val Leu 
                725                 730                 735     


Val Ser Ala Gly Phe Asp Ala Ala Arg Gly Asp Pro Leu Gly Gly Cys 
            740                 745                 750         


Gln Val Ser Pro Glu Gly Tyr Ala His Leu Thr His Leu Leu Met Gly 
        755                 760                 765             


Leu Ala Ser Gly Arg Ile Ile Leu Ile Leu Glu Gly Gly Tyr Asn Leu 
    770                 775                 780                 


Thr Ser Ile Ser Glu Ser Met Ala Ala Cys Thr Arg Ser Leu Leu Gly 
785                 790                 795                 800 


Asp Pro Pro Pro Leu Leu Thr Leu Pro Arg Pro Pro Leu Ser Gly Ala 
                805                 810                 815     


Leu Ala Ser Ile Thr Glu Thr Ile Gln Val His Arg Arg Tyr Trp Arg 
            820                 825                 830         


Ser Leu Arg Val Met Lys Val Glu Asp Arg Glu Gly Pro Ser Ser Ser 
        835                 840                 845             


Lys Leu Val Thr Lys Lys Ala Pro Gln Pro Ala Lys Pro Arg Leu Ala 
    850                 855                 860                 


Glu Arg Met Thr Thr Arg Glu Lys Lys Val Leu Glu Ala Gly Met Gly 
865                 870                 875                 880 


Lys Val Thr Ser Ala Ser Phe Gly Glu Glu Ser Thr Pro Gly Gln Thr 
                885                 890                 895     


Asn Ser Glu Thr Ala Val Val Ala Leu Thr Gln Asp Gln Pro Ser Glu 
            900                 905                 910         


Ala Ala Thr Gly Gly Ala Thr Leu Ala Gln Thr Ile Ser Glu Ala Ala 
        915                 920                 925             


Ile Gly Gly Ala Met Leu Gly Gln Thr Thr Ser Glu Glu Ala Val Gly 
    930                 935                 940                 


Gly Ala Thr Pro Asp Gln Thr Thr Ser Glu Glu Thr Val Gly Gly Ala 
945                 950                 955                 960 


Ile Leu Asp Gln Thr Thr Ser Glu Asp Ala Val Gly Gly Ala Thr Leu 
                965                 970                 975     


Gly Gln Thr Thr Ser Glu Glu Ala Val Gly Gly Ala Thr Leu Ala Gln 
            980                 985                 990         


Thr Thr Ser Glu Ala Ala Met Glu  Gly Ala Thr Leu Asp  Gln Thr Thr 
        995                 1000                 1005             


Ser Glu  Glu Ala Pro Gly Gly  Thr Glu Leu Ile Gln  Thr Pro Leu 
    1010                 1015                 1020             


Ala Ser  Ser Thr Asp His Gln  Thr Pro Pro Thr Ser  Pro Val Gln 
    1025                 1030                 1035             


Gly Thr  Thr Pro Gln Ile Ser  Pro Ser Thr Leu Ile  Gly Ser Leu 
    1040                 1045                 1050             


Arg Thr  Leu Glu Leu Gly Ser  Glu Ser Gln Gly Ala  Ser Glu Ser 
    1055                 1060                 1065             


Gln Ala  Pro Gly Glu Glu Asn  Leu Leu Gly Glu Ala  Ala Gly Gly 
    1070                 1075                 1080             


Gln Asp  Met Ala Asp Ser Met  Leu Met Gln Gly Ser  Arg Gly Leu 
    1085                 1090                 1095             


Thr Asp  Gln Ala Ile Phe Tyr  Ala Val Thr Pro Leu  Pro Trp Cys 
    1100                 1105                 1110             


Pro His  Leu Val Ala Val Cys  Pro Ile Pro Ala Ala  Gly Leu Asp 
    1115                 1120                 1125             


Val Thr  Gln Pro Cys Gly Asp  Cys Gly Thr Ile Gln  Glu Asn Trp 
    1130                 1135                 1140             


Val Cys  Leu Ser Cys Tyr Gln  Val Tyr Cys Gly Arg  Tyr Ile Asn 
    1145                 1150                 1155             


Gly His  Met Leu Gln His His  Gly Asn Ser Gly His  Pro Leu Val 
    1160                 1165                 1170             


Leu Ser  Tyr Ile Asp Leu Ser  Ala Trp Cys Tyr Tyr  Cys Gln Ala 
    1175                 1180                 1185             


Tyr Val  His His Gln Ala Leu  Leu Asp Val Lys Asn  Ile Ala His 
    1190                 1195                 1200             


Gln Asn  Lys Phe Gly Glu Asp  Met Pro His Pro His  
    1205                 1210                 1215 


<210>  4909
<211>  954
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC7__Homo_sapiens__NP_001091886

<400>  4909

Met His Ser Pro Gly Ala Asp Gly Thr Gln Val Ser Pro Gly Ala His 
1               5                   10                  15      


Tyr Cys Ser Pro Thr Gly Ala Gly Cys Pro Arg Pro Cys Ala Asp Thr 
            20                  25                  30          


Pro Gly Pro Gln Pro Gln Pro Met Asp Leu Arg Val Gly Gln Arg Pro 
        35                  40                  45              


Pro Val Glu Pro Pro Pro Glu Pro Thr Leu Leu Ala Leu Gln Arg Pro 
    50                  55                  60                  


Gln Arg Leu His His His Leu Phe Leu Ala Gly Leu Gln Gln Gln Arg 
65                  70                  75                  80  


Ser Val Glu Pro Met Arg Leu Ser Met Asp Thr Pro Met Pro Glu Leu 
                85                  90                  95      


Gln Val Gly Pro Gln Glu Gln Glu Leu Arg Gln Leu Leu His Lys Asp 
            100                 105                 110         


Lys Ser Lys Arg Ser Ala Val Ala Ser Ser Val Val Lys Gln Lys Leu 
        115                 120                 125             


Ala Glu Val Ile Leu Lys Lys Gln Gln Ala Ala Leu Glu Arg Thr Val 
    130                 135                 140                 


His Pro Asn Ser Pro Gly Ile Pro Tyr Arg Thr Leu Glu Pro Leu Glu 
145                 150                 155                 160 


Thr Glu Gly Ala Thr Arg Ser Met Leu Ser Ser Phe Leu Pro Pro Val 
                165                 170                 175     


Pro Ser Leu Pro Ser Asp Pro Pro Glu His Phe Pro Leu Arg Lys Thr 
            180                 185                 190         


Val Ser Glu Pro Asn Leu Lys Leu Arg Tyr Lys Pro Lys Lys Ser Leu 
        195                 200                 205             


Glu Arg Arg Lys Asn Pro Leu Leu Arg Lys Glu Ser Ala Pro Pro Ser 
    210                 215                 220                 


Leu Arg Arg Arg Pro Ala Glu Thr Leu Gly Asp Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Ser Ser Thr Pro Ala Ser Gly Cys Ser Ser Pro Asn Asp Ser Glu His 
                245                 250                 255     


Gly Pro Asn Pro Ile Leu Gly Ser Glu Ala Asp Ser Asp Arg Arg Thr 
            260                 265                 270         


His Pro Thr Leu Gly Pro Arg Gly Pro Ile Leu Gly Ser Pro His Thr 
        275                 280                 285             


Pro Leu Phe Leu Pro His Gly Leu Glu Pro Glu Ala Gly Gly Thr Leu 
    290                 295                 300                 


Pro Ser Arg Leu Gln Pro Ile Leu Leu Leu Asp Pro Ser Gly Ser His 
305                 310                 315                 320 


Ala Pro Leu Leu Thr Val Pro Gly Leu Gly Pro Leu Pro Phe His Phe 
                325                 330                 335     


Ala Gln Ser Leu Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His 
            340                 345                 350         


Trp Pro Leu Ser Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr 
        355                 360                 365             


Ala Pro Pro Pro Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys 
    370                 375                 380                 


Thr His Val Gln Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro 
385                 390                 395                 400 


Arg Leu Arg Gln Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly 
                405                 410                 415     


Gly Pro Gly Gln Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly 
            420                 425                 430         


His Gly Gln Pro Glu Ala Arg Gly Pro Ala Pro Leu Gln Gln His Pro 
        435                 440                 445             


Gln Val Leu Leu Trp Glu Gln Gln Arg Leu Ala Gly Arg Leu Pro Arg 
    450                 455                 460                 


Gly Ser Thr Gly Asp Thr Val Leu Leu Pro Leu Ala Gln Gly Gly His 
465                 470                 475                 480 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ala Pro Ala Ser Leu 
                485                 490                 495     


Ser Ala Pro Glu Pro Ala Ser Gln Ala Arg Val Leu Ser Ser Ser Glu 
            500                 505                 510         


Thr Pro Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu Ile Tyr Asp Ser 
        515                 520                 525             


Val Met Leu Lys His Gln Cys Ser Cys Gly Asp Asn Ser Arg His Pro 
    530                 535                 540                 


Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Arg 
545                 550                 555                 560 


Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg Gly Arg Lys Ala Ser Leu 
                565                 570                 575     


Glu Glu Leu Gln Ser Val His Ser Glu Arg His Val Leu Leu Tyr Gly 
            580                 585                 590         


Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys Leu Ala Gly 
        595                 600                 605             


Leu Leu Ala Gln Arg Met Phe Val Met Leu Pro Cys Gly Gly Val Gly 
    610                 615                 620                 


Val Asp Thr Asp Thr Ile Trp Asn Glu Leu His Ser Ser Asn Ala Ala 
625                 630                 635                 640 


Arg Trp Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys Val Ala Ser 
                645                 650                 655     


Arg Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His 
            660                 665                 670         


Ala Asp His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala 
        675                 680                 685             


Ile Ala Cys Arg Gln Leu Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu 
    690                 695                 700                 


Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Thr Phe 
705                 710                 715                 720 


Tyr Gln Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg His Asp Asp 
                725                 730                 735     


Gly Asn Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val Gly Ala Gly 
            740                 745                 750         


Ser Gly Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly Gly Leu Asp 
        755                 760                 765             


Pro Pro Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg Ile Val Val 
    770                 775                 780                 


Met Pro Ile Ala Arg Glu Phe Ser Pro Asp Leu Val Leu Val Ser Ala 
785                 790                 795                 800 


Gly Phe Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly Gly Tyr His 
                805                 810                 815     


Val Ser Ala Lys Cys Phe Gly Tyr Met Thr Gln Gln Leu Met Asn Leu 
            820                 825                 830         


Ala Gly Gly Ala Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr 
        835                 840                 845             


Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu Leu Gly Asn 
    850                 855                 860                 


Arg Val Asp Pro Leu Ser Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu 
865                 870                 875                 880 


Asn Ala Ile Arg Ser Leu Glu Ala Val Ile Arg Val His Ser Lys Tyr 
                885                 890                 895     


Trp Gly Cys Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro 
            900                 905                 910         


Arg Val Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu 
        915                 920                 925             


Ala Ser Leu Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln 
    930                 935                 940                 


Leu Val Glu Glu Glu Glu Pro Met Asn Leu 
945                 950                 


<210>  4910
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC8__Homo_sapiens__NP_001159890

<400>  4910

Met Glu Glu Pro Glu Glu Pro Ala Asp Ser Gly Gln Ser Leu Val Pro 
1               5                   10                  15      


Val Tyr Ile Tyr Ser Pro Glu Tyr Val Ser Met Cys Asp Ser Leu Ala 
            20                  25                  30          


Lys Ile Pro Lys Arg Ala Ser Met Val His Ser Leu Ile Glu Ala Tyr 
        35                  40                  45              


Ala Leu His Lys Gln Met Arg Asp Glu Ala Ser Gly Phe Cys Tyr Leu 
    50                  55                  60                  


Asn Asp Ala Val Leu Gly Ile Leu Arg Leu Arg Arg Lys Phe Glu Arg 
65                  70                  75                  80  


Ile Leu Tyr Val Asp Leu Asp Leu His His Gly Asp Gly Val Glu Asp 
                85                  90                  95      


Ala Phe Ser Phe Thr Ser Lys Val Met Thr Val Ser Leu His Lys Phe 
            100                 105                 110         


Ser Pro Gly Phe Phe Pro Gly Thr Gly Asp Val Ser Asp Val Gly Leu 
        115                 120                 125             


Gly Lys Gly Arg Tyr Tyr Ser Val Asn Val Pro Ile Gln Asp Gly Ile 
    130                 135                 140                 


Gln Asp Glu Lys Tyr Tyr Gln Ile Cys Glu Ser Val Leu Lys Glu Val 
145                 150                 155                 160 


Tyr Gln Ala Phe Asn Pro Lys Ala Val Val Leu Gln Leu Gly Ala Asp 
                165                 170                 175     


Thr Ile Ala Gly Asp Pro Met Cys Ser Phe Asn Met Thr Pro Val Gly 
            180                 185                 190         


Ile Gly Lys Cys Leu Lys Tyr Ile Leu Gln Trp Gln Leu Ala Thr Leu 
        195                 200                 205             


Ile Leu Gly Gly Gly Gly Tyr Asn Leu Ala Asn Thr Ala Arg Cys Trp 
    210                 215                 220                 


Thr Tyr Leu Thr Gly Val Ile Leu Gly Lys Thr Leu Ser Ser Glu Ile 
225                 230                 235                 240 


Pro Asp His Glu Phe Phe Thr Ala Tyr Gly Pro Asp Tyr Val Leu Glu 
                245                 250                 255     


Ile Thr Pro Ser Cys Arg Pro Asp Arg Asn Glu Pro His Arg Ile Gln 
            260                 265                 270         


Gln Ile Leu Asn Tyr Ile Lys Gly Asn Leu Lys His Val Val 
        275                 280                 285     


<210>  4911
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDAC9__Homo_sapiens__NP_001191073

<400>  4911

Met Met Ser Ser Pro Ala Gln Pro Asp Leu Met Trp Asn Leu Val Pro 
1               5                   10                  15      


Trp Val Leu Phe Cys Gly Cys Cys Arg Ile Phe Pro Asp Gly Val Ala 
            20                  25                  30          


Gly Arg Glu Gln Leu Leu Ala Gln Gln Arg Met His Ser Met Ile Ser 
        35                  40                  45              


Ser Val Asp Val Lys Ser Glu Val Pro Val Gly Leu Glu Pro Ile Ser 
    50                  55                  60                  


Pro Leu Asp Leu Arg Thr Asp Leu Arg Met Met Met Pro Val Val Asp 
65                  70                  75                  80  


Pro Val Val Arg Glu Lys Gln Leu Gln Gln Glu Leu Leu Leu Ile Gln 
                85                  90                  95      


Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu Ile Ala Glu Phe Gln Lys 
            100                 105                 110         


Gln His Glu Asn Leu Thr Arg Gln His Gln Ala Gln Leu Gln Glu His 
        115                 120                 125             


Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln Gln Glu Leu Leu Glu Lys 
    130                 135                 140                 


Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu Gln Glu Val Glu Arg His 
145                 150                 155                 160 


Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg Gly Lys Asp Arg Gly Arg 
                165                 170                 175     


Glu Arg Ala Val Ala Ser Thr Glu Val Lys Gln Lys Leu Gln Glu Phe 
            180                 185                 190         


Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr Pro Thr Asn Gly Lys Asn 
        195                 200                 205             


His Ser Val Ser Arg His Pro Lys Leu Trp Tyr Thr Ala Ala His His 
    210                 215                 220                 


Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu Ser Gly Thr Ser Pro Ser 
225                 230                 235                 240 


Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp Ala Lys Asp Asp Phe Pro 
                245                 250                 255     


Leu Arg Lys Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly Ser Gly 
            260                 265                 270         


Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu Asn Glu 
        275                 280                 285             


Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val Ser Gln 
    290                 295                 300                 


Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser Leu Tyr 
305                 310                 315                 320 


Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala Val Pro 
                325                 330                 335     


Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys Cys Glu 
            340                 345                 350         


Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr Gly Gly 
        355                 360                 365             


Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu Gly Lys 
    370                 375                 380                 


Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu Leu Lys 
385                 390                 395                 400 


Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val Pro Leu 
                405                 410                 415     


His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro Gly Ile 
            420                 425                 430         


Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg Thr Gln 
        435                 440                 445             


Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile Gln Gln 
    450                 455                 460                 


Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln Gln Ile 
465                 470                 475                 480 


His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys Gln Pro 
                485                 490                 495     


Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp Gln Ala 
            500                 505                 510         


Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg Ser Asp 
        515                 520                 525             


Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala Val Lys 
    530                 535                 540                 


Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile Gln Glu 
545                 550                 555                 560 


Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Val Ile Gly Lys 
                565                 570                 575     


Asp Leu Ala Pro Gly Phe Val Ile Lys Val Ile Ile 
            580                 585             


<210>  4912
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDC__Homo_sapiens__NP_002103

<400>  4912

Met Met Glu Pro Glu Glu Tyr Arg Glu Arg Gly Arg Glu Met Val Asp 
1               5                   10                  15      


Tyr Ile Cys Gln Tyr Leu Ser Thr Val Arg Glu Arg Arg Val Thr Pro 
            20                  25                  30          


Asp Val Gln Pro Gly Tyr Leu Arg Ala Gln Leu Pro Glu Ser Ala Pro 
        35                  40                  45              


Glu Asp Pro Asp Ser Trp Asp Ser Ile Phe Gly Asp Ile Glu Arg Ile 
    50                  55                  60                  


Ile Met Pro Gly Val Val His Trp Gln Ser Pro His Met His Ala Tyr 
65                  70                  75                  80  


Tyr Pro Ala Leu Thr Ser Trp Pro Ser Leu Leu Gly Asp Met Leu Ala 
                85                  90                  95      


Asp Ala Ile Asn Cys Leu Gly Phe Thr Trp Ala Ser Ser Pro Ala Cys 
            100                 105                 110         


Thr Glu Leu Glu Met Asn Val Met Asp Trp Leu Ala Lys Met Leu Gly 
        115                 120                 125             


Leu Pro Glu His Phe Leu His His His Pro Ser Ser Gln Gly Gly Gly 
    130                 135                 140                 


Val Leu Gln Ser Thr Val Ser Glu Ser Thr Leu Ile Ala Leu Leu Ala 
145                 150                 155                 160 


Ala Arg Lys Asn Lys Ile Leu Glu Met Lys Thr Ser Glu Pro Asp Ala 
                165                 170                 175     


Asp Glu Ser Cys Leu Asn Ala Arg Leu Val Ala Tyr Ala Ser Asp Gln 
            180                 185                 190         


Ala His Ser Ser Val Glu Lys Ala Gly Leu Ile Ser Leu Val Lys Met 
        195                 200                 205             


Lys Phe Leu Pro Val Asp Asp Asn Phe Ser Leu Arg Gly Glu Ala Leu 
    210                 215                 220                 


Gln Lys Ala Ile Glu Glu Asp Lys Gln Arg Gly Leu Val Pro Val Phe 
225                 230                 235                 240 


Val Cys Ala Thr Leu Gly Thr Thr Gly Val Cys Ala Phe Asp Cys Leu 
                245                 250                 255     


Ser Glu Leu Gly Pro Ile Cys Ala Arg Glu Gly Leu Trp Leu His Ile 
            260                 265                 270         


Asp Ala Ala Tyr Ala Gly Thr Ala Phe Leu Cys Pro Glu Phe Arg Gly 
        275                 280                 285             


Phe Leu Lys Gly Ile Glu Tyr Ala Asp Ser Phe Thr Phe Asn Pro Ser 
    290                 295                 300                 


Lys Trp Met Met Val His Phe Asp Cys Thr Gly Phe Trp Val Lys Asp 
305                 310                 315                 320 


Lys Tyr Lys Leu Gln Gln Thr Phe Ser Val Asn Pro Ile Tyr Leu Arg 
                325                 330                 335     


His Ala Asn Ser Gly Val Ala Thr Asp Phe Met His Trp Gln Ile Pro 
            340                 345                 350         


Leu Ser Arg Arg Phe Arg Ser Val Lys Leu Trp Phe Val Ile Arg Ser 
        355                 360                 365             


Phe Gly Val Lys Asn Leu Gln Ala His Val Arg His Gly Thr Glu Met 
    370                 375                 380                 


Ala Lys Tyr Phe Glu Ser Leu Val Arg Asn Asp Pro Ser Phe Glu Ile 
385                 390                 395                 400 


Pro Ala Lys Arg His Leu Gly Leu Val Val Phe Arg Leu Lys Gly Pro 
                405                 410                 415     


Asn Cys Leu Thr Glu Asn Val Leu Lys Glu Ile Ala Lys Ala Gly Arg 
            420                 425                 430         


Leu Phe Leu Ile Pro Ala Thr Ile Gln Asp Lys Leu Ile Ile Arg Phe 
        435                 440                 445             


Thr Val Thr Ser Gln Phe Thr Thr Arg Asp Asp Ile Leu Arg Asp Trp 
    450                 455                 460                 


Asn Leu Ile Arg Asp Ala Ala Thr Leu Ile Leu Ser Gln His Cys Thr 
465                 470                 475                 480 


Ser Gln Pro Ser Pro Arg Val Gly Asn Leu Ile Ser Gln Ile Arg Gly 
                485                 490                 495     


Ala Arg Ala Trp Ala Cys Gly Thr Ser Leu Gln Ser Val Ser Gly Ala 
            500                 505                 510         


Gly Asp Asp Pro Val Gln Ala Arg Lys Ile Ile Lys Gln Pro Gln Arg 
        515                 520                 525             


Val Gly Ala Gly Pro Met Lys Arg Glu Asn Gly Leu His Leu Glu Thr 
    530                 535                 540                 


Leu Leu Asp Pro Val Asp Asp Cys Phe Ser Glu Glu Ala Pro Asp Ala 
545                 550                 555                 560 


Thr Lys His Lys Leu Ser Ser Phe Leu Phe Ser Tyr Leu Ser Val Gln 
                565                 570                 575     


Thr Lys Lys Lys Thr Val Arg Ser Leu Ser Cys Asn Ser Val Pro Val 
            580                 585                 590         


Ser Ala Gln Lys Pro Leu Pro Thr Glu Ala Ser Val Lys Asn Gly Gly 
        595                 600                 605             


Ser Ser Arg Val Arg Ile Phe Ser Arg Phe Pro Glu Asp Met Met Met 
    610                 615                 620                 


Leu Lys Lys Ser Ala Phe Lys Lys Leu Ile Lys Phe Tyr Ser Val Pro 
625                 630                 635                 640 


Ser Phe Pro Glu Cys Ser Ser Gln Cys Gly Leu Gln Leu Pro Cys Cys 
                645                 650                 655     


Pro Leu Gln Ala Met Val 
            660         


<210>  4913
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDDC2__Homo_sapiens__NP_057147

<400>  4913

Met Ala Ser Val Ser Ser Ala Thr Phe Ser Gly His Gly Ala Arg Ser 
1               5                   10                  15      


Leu Leu Gln Phe Leu Arg Leu Val Gly Gln Leu Lys Arg Val Pro Arg 
            20                  25                  30          


Thr Gly Trp Val Tyr Arg Asn Val Gln Arg Pro Glu Ser Val Ser Asp 
        35                  40                  45              


His Met Tyr Arg Met Ala Val Met Ala Met Val Ile Lys Asp Asp Arg 
    50                  55                  60                  


Leu Asn Lys Asp Arg Cys Val Arg Leu Ala Leu Val His Asp Met Ala 
65                  70                  75                  80  


Glu Cys Ile Val Gly Asp Ile Ala Pro Ala Asp Asn Ile Pro Lys Glu 
                85                  90                  95      


Glu Lys His Arg Arg Glu Glu Glu Ala Met Lys Gln Ile Thr Gln Leu 
            100                 105                 110         


Leu Pro Glu Asp Leu Arg Lys Glu Leu Tyr Glu Leu Trp Glu Glu Tyr 
        115                 120                 125             


Glu Thr Gln Ser Ser Ala Glu Ala Lys Phe Val Lys Gln Leu Asp Gln 
    130                 135                 140                 


Cys Glu Met Ile Leu Gln Ala Ser Glu Tyr Glu Asp Leu Glu His Lys 
145                 150                 155                 160 


Pro Gly Arg Leu Gln Asp Phe Tyr Asp Ser Thr Ala Gly Lys Phe Asn 
                165                 170                 175     


His Pro Glu Ile Val Gln Leu Val Ser Glu Leu Glu Ala Glu Arg Ser 
            180                 185                 190         


Thr Asn Ile Ala Ala Ala Ala Ser Glu Pro His Ser 
        195                 200                 


<210>  4914
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDGF__Homo_sapiens__NP_001119522

<400>  4914

Met His Pro Glu Gly Gly Gln Phe Val Pro Gln Leu Leu Gly His Leu 
1               5                   10                  15      


Leu Ala Thr Lys Leu Lys Arg Phe Leu Leu Ser Lys Gly Gly Arg Arg 
            20                  25                  30          


Ala Gln Ile Pro Asp Val Ser Arg Ala Thr Pro His Thr Ile Asp Glu 
        35                  40                  45              


Met Pro Glu Ala Ala Val Lys Ser Thr Ala Asn Lys Tyr Gln Val Phe 
    50                  55                  60                  


Phe Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe 
65                  70                  75                  80  


Pro Tyr Glu Glu Ser Lys Glu Lys Phe Gly Lys Pro Asn Lys Arg Lys 
                85                  90                  95      


Gly Phe Ser Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Thr Val Lys 
            100                 105                 110         


Ala Ser Gly Tyr Gln Ser Ser Gln Lys Lys Ser Cys Val Glu Glu Pro 
        115                 120                 125             


Glu Pro Glu Pro Glu Ala Ala Glu Gly Asp Gly Asp Lys Lys Gly Asn 
    130                 135                 140                 


Ala Glu Gly Ser Ser Asp Glu Glu Gly Lys Leu Val Ile Asp Glu Pro 
145                 150                 155                 160 


Ala Lys Glu Lys Asn Glu Lys Gly Ala Leu Lys Arg Arg Ala Gly Asp 
                165                 170                 175     


Leu Leu Glu Asp Ser Pro Lys Arg Pro Lys Glu Ala Glu Asn Pro Glu 
            180                 185                 190         


Gly Glu Glu Lys Glu Ala Ala Thr Leu Glu Val Glu Arg Pro Leu Pro 
        195                 200                 205             


Met Glu Val Glu Lys Asn Ser Thr Pro Ser Glu Pro Gly Ser Gly Arg 
    210                 215                 220                 


Gly Pro Pro Gln Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Ala 
225                 230                 235                 240 


Thr Lys Glu Asp Ala Glu Ala Pro Gly Ile Arg Asp His Glu Ser Leu 
                245                 250                 255     


<210>  4915
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDGFL1__Homo_sapiens__NP_612641

<400>  4915

Met Ser Ala Tyr Gly Met Pro Met Tyr Lys Ser Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Leu Lys Gly Tyr Ala His Trp Pro Ala Arg Ile Glu His Met 
            20                  25                  30          


Thr Gln Pro Asn Arg Tyr Gln Val Phe Phe Phe Gly Thr His Glu Thr 
        35                  40                  45              


Ala Phe Leu Ser Pro Lys Arg Leu Phe Pro Tyr Lys Glu Cys Lys Glu 
    50                  55                  60                  


Lys Phe Gly Lys Pro Asn Lys Arg Arg Gly Phe Ser Ala Gly Leu Trp 
65                  70                  75                  80  


Glu Ile Glu Asn Asn Pro Thr Val Gln Ala Ser Asp Cys Pro Leu Ala 
                85                  90                  95      


Ser Glu Lys Gly Ser Gly Asp Gly Pro Trp Pro Glu Pro Glu Ala Ala 
            100                 105                 110         


Glu Gly Asp Glu Asp Lys Pro Thr His Ala Gly Gly Gly Gly Asp Glu 
        115                 120                 125             


Leu Gly Lys Pro Asp Asp Asp Lys Pro Thr Glu Glu Glu Lys Gly Pro 
    130                 135                 140                 


Leu Lys Arg Ser Ala Gly Asp Pro Pro Glu Asp Ala Pro Lys Arg Pro 
145                 150                 155                 160 


Lys Glu Ala Ala Pro Asp Gln Glu Glu Glu Ala Glu Ala Glu Arg Ala 
                165                 170                 175     


Ala Glu Ala Glu Arg Ala Ala Ala Ala Ala Ala Ala Thr Ala Val Asp 
            180                 185                 190         


Glu Glu Ser Pro Phe Leu Val Ala Val Glu Asn Gly Ser Ala Pro Ser 
        195                 200                 205             


Glu Pro Gly Leu Val Cys Glu Pro Pro Gln Pro Glu Glu Glu Glu Leu 
    210                 215                 220                 


Arg Glu Glu Glu Val Ala Asp Glu Glu Ala Ser Gln Glu Trp His Ala 
225                 230                 235                 240 


Glu Ala Pro Gly Gly Gly Asp Arg Asp Ser Leu 
                245                 250     


<210>  4916
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDGFRP3__Homo_sapiens__NP_057157

<400>  4916

Met Ala Arg Pro Arg Pro Arg Glu Tyr Lys Ala Gly Asp Leu Val Phe 
1               5                   10                  15      


Ala Lys Met Lys Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Glu Leu 
            20                  25                  30          


Pro Glu Gly Ala Val Lys Pro Pro Ala Asn Lys Tyr Pro Ile Phe Phe 
        35                  40                  45              


Phe Gly Thr His Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro 
    50                  55                  60                  


Tyr Lys Glu Tyr Lys Asp Lys Phe Gly Lys Ser Asn Lys Arg Lys Gly 
65                  70                  75                  80  


Phe Asn Glu Gly Leu Trp Glu Ile Glu Asn Asn Pro Gly Val Lys Phe 
                85                  90                  95      


Thr Gly Tyr Gln Ala Ile Gln Gln Gln Ser Ser Ser Glu Thr Glu Gly 
            100                 105                 110         


Glu Gly Gly Asn Thr Ala Asp Ala Ser Ser Glu Glu Glu Gly Asp Arg 
        115                 120                 125             


Val Glu Glu Asp Gly Lys Gly Lys Arg Lys Asn Glu Lys Ala Gly Ser 
    130                 135                 140                 


Lys Arg Lys Lys Ser Tyr Thr Ser Lys Lys Ser Ser Lys Gln Ser Arg 
145                 150                 155                 160 


Lys Ser Pro Gly Asp Glu Asp Asp Lys Asp Cys Lys Glu Glu Glu Asn 
                165                 170                 175     


Lys Ser Ser Ser Glu Gly Gly Asp Ala Gly Asn Asp Thr Arg Asn Thr 
            180                 185                 190         


Thr Ser Asp Leu Gln Lys Thr Ser Glu Gly Thr 
        195                 200             


<210>  4917
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDHD1__Homo_sapiens__NP_001129037

<400>  4917

Met Ala Ala Pro Pro Gln Pro Val Thr His Leu Ile Phe Asp Met Asp 
1               5                   10                  15      


Gly Leu Leu Leu Gly Tyr Thr Gly Ser Ile Val Ala Ala Ala Ser Gly 
            20                  25                  30          


Glu Ser Ser Arg Gly Leu Gln Ser Arg Trp Thr Asp Thr Glu Arg Leu 
        35                  40                  45              


Tyr Ser Val Val Phe Gln Glu Ile Cys Asn Arg Tyr Asp Lys Lys Tyr 
    50                  55                  60                  


Ser Trp Asp Val Lys Ser Leu Val Met Gly Lys Lys Ala Leu Glu Ala 
65                  70                  75                  80  


Ala Gln Ile Ile Ile Asp Val Leu Gln Leu Pro Met Ser Lys Glu Glu 
                85                  90                  95      


Leu Val Glu Glu Ser Gln Thr Lys Leu Lys Glu Val Phe Pro Thr Ala 
            100                 105                 110         


Ala Leu Met Pro Gly Ala Glu Lys Leu Ile Ile His Leu Arg Lys His 
        115                 120                 125             


Gly Ile Pro Phe Ala Leu Ala Thr Ser Ser Gly Ser Ala Ser Phe Asp 
    130                 135                 140                 


Met Lys Thr Ser Arg His Lys Glu Phe Phe Ser Leu Phe Ser His Ile 
145                 150                 155                 160 


Val Leu Gly Asp Asp Pro Glu Val Gln His Gly Lys Pro Asp Pro Asp 
                165                 170                 175     


Ile Phe Leu Ala Cys Ala Lys Arg Phe Ser Pro Pro Pro Ala Met Glu 
            180                 185                 190         


Lys Cys Leu Val Phe Glu Asp Ala Pro Asn Gly Val Glu Ala Ala Leu 
        195                 200                 205             


Ala Ala Gly Met Gln Val Val Met Val Pro Asp Gly Asn Leu Ser Arg 
    210                 215                 220                 


Asp Leu Thr Thr Lys Ala Thr Leu Val Leu Asn Ser Leu Gln Asp Phe 
225                 230                 235                 240 


Gln Pro Glu Leu Phe Gly Leu Pro Ser Tyr Glu 
                245                 250     


<210>  4918
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDLBP__Homo_sapiens__NP_001230829

<400>  4918

Met His Leu Ala Glu Arg Asp Arg Trp Leu Phe Val Ala Thr Val Met 
1               5                   10                  15      


Met His Phe Val Ser Ile Lys Ser Gly Phe Pro Gly Leu Cys Val Gly 
            20                  25                  30          


Val Arg Ser Thr Met Ser Ser Val Ala Val Leu Thr Gln Glu Ser Phe 
        35                  40                  45              


Ala Glu His Arg Ser Gly Leu Val Pro Gln Gln Ile Lys Val Ala Thr 
    50                  55                  60                  


Leu Asn Ser Glu Glu Glu Ser Asp Pro Pro Thr Tyr Lys Asp Ala Phe 
65                  70                  75                  80  


Pro Pro Leu Pro Glu Lys Ala Ala Cys Leu Glu Ser Ala Gln Glu Pro 
                85                  90                  95      


Ala Gly Ala Trp Gly Asn Lys Ile Arg Pro Ile Lys Ala Ser Val Ile 
            100                 105                 110         


Thr Gln Val Phe His Val Pro Leu Glu Glu Arg Lys Tyr Lys Asp Met 
        115                 120                 125             


Asn Gln Phe Gly Glu Gly Glu Gln Ala Lys Ile Cys Leu Glu Ile Met 
    130                 135                 140                 


Gln Arg Thr Gly Ala His Leu Glu Leu Ser Leu Ala Lys Asp Gln Gly 
145                 150                 155                 160 


Leu Ser Ile Met Val Ser Gly Lys Leu Asp Ala Val Met Lys Ala Arg 
                165                 170                 175     


Lys Asp Ile Val Ala Arg Leu Gln Thr Gln Ala Ser Ala Thr Val Ala 
            180                 185                 190         


Ile Pro Lys Glu His His Arg Phe Val Ile Gly Lys Asn Gly Glu Lys 
        195                 200                 205             


Leu Gln Asp Leu Glu Leu Lys Thr Ala Thr Lys Ile Gln Ile Pro Arg 
    210                 215                 220                 


Pro Asp Asp Pro Ser Asn Gln Ile Lys Ile Thr Gly Thr Lys Glu Gly 
225                 230                 235                 240 


Ile Glu Lys Ala Arg His Glu Val Leu Leu Ile Ser Ala Glu Gln Asp 
                245                 250                 255     


Lys Arg Ala Val Glu Arg Leu Glu Val Glu Lys Ala Phe His Pro Phe 
            260                 265                 270         


Ile Ala Gly Pro Tyr Asn Arg Leu Val Gly Glu Ile Met Gln Glu Thr 
        275                 280                 285             


Gly Thr Arg Ile Asn Ile Pro Pro Pro Ser Val Asn Arg Thr Glu Ile 
    290                 295                 300                 


Val Phe Thr Gly Glu Lys Glu Gln Leu Ala Gln Ala Val Ala Arg Ile 
305                 310                 315                 320 


Lys Lys Ile Tyr Glu Glu Lys Ala Asn Ser Phe Thr Val Ser Ser Val 
                325                 330                 335     


Ala Ala Pro Ser Trp Leu His Arg Phe Ile Ile Gly Lys Lys Gly Gln 
            340                 345                 350         


Asn Leu Ala Lys Ile Thr Gln Gln Met Pro Lys Val His Ile Glu Phe 
        355                 360                 365             


Thr Glu Gly Glu Asp Lys Ile Thr Leu Glu Gly Pro Thr Glu Asp Val 
    370                 375                 380                 


Asn Val Ala Gln Glu Gln Ile Glu Gly Met Val Lys Asp Leu Ile Asn 
385                 390                 395                 400 


Arg Met Asp Tyr Val Glu Ile Asn Ile Asp His Lys Phe His Arg His 
                405                 410                 415     


Leu Ile Gly Lys Ser Gly Ala Asn Ile Asn Arg Ile Lys Asp Gln Tyr 
            420                 425                 430         


Lys Val Ser Val Arg Ile Pro Pro Asp Ser Glu Lys Ser Asn Leu Ile 
        435                 440                 445             


Arg Ile Glu Gly Asp Pro Gln Gly Val Gln Gln Ala Lys Arg Glu Leu 
    450                 455                 460                 


Leu Glu Leu Ala Ser Arg Met Glu Asn Glu Arg Thr Lys Asp Leu Ile 
465                 470                 475                 480 


Ile Glu Gln Arg Phe His Arg Thr Ile Ile Gly Gln Lys Gly Glu Arg 
                485                 490                 495     


Ile Arg Glu Ile Arg Asp Lys Phe Pro Glu Val Ile Ile Asn Phe Pro 
            500                 505                 510         


Asp Pro Ala Gln Lys Ser Asp Ile Val Gln Leu Arg Gly Pro Lys Asn 
        515                 520                 525             


Glu Val Glu Lys Cys Thr Lys Tyr Met Gln Lys Met Val Ala Asp Leu 
    530                 535                 540                 


Val Glu Asn Ser Tyr Ser Ile Ser Val Pro Ile Phe Lys Gln Phe His 
545                 550                 555                 560 


Lys Asn Ile Ile Gly Lys Gly Gly Ala Asn Ile Lys Lys Ile Arg Glu 
                565                 570                 575     


Glu Ser Asn Thr Lys Ile Asp Leu Pro Ala Glu Asn Ser Asn Ser Glu 
            580                 585                 590         


Thr Ile Ile Ile Thr Gly Lys Arg Ala Asn Cys Glu Ala Ala Arg Ser 
        595                 600                 605             


Arg Ile Leu Ser Ile Gln Lys Asp Leu Ala Asn Ile Ala Glu Val Glu 
    610                 615                 620                 


Val Ser Ile Pro Ala Lys Leu His Asn Ser Leu Ile Gly Thr Lys Gly 
625                 630                 635                 640 


Arg Leu Ile Arg Ser Ile Met Glu Glu Cys Gly Gly Val His Ile His 
                645                 650                 655     


Phe Pro Val Glu Gly Ser Gly Ser Asp Thr Val Val Ile Arg Gly Pro 
            660                 665                 670         


Ser Ser Asp Val Glu Lys Ala Lys Lys Gln Leu Leu His Leu Ala Glu 
        675                 680                 685             


Glu Lys Gln Thr Lys Ser Phe Thr Val Asp Ile Arg Ala Lys Pro Glu 
    690                 695                 700                 


Tyr His Lys Phe Leu Ile Gly Lys Gly Gly Gly Lys Ile Arg Lys Val 
705                 710                 715                 720 


Arg Asp Ser Thr Gly Ala Arg Val Ile Phe Pro Ala Ala Glu Asp Lys 
                725                 730                 735     


Asp Gln Asp Leu Ile Thr Ile Ile Gly Lys Glu Asp Ala Val Arg Glu 
            740                 745                 750         


Ala Gln Lys Glu Leu Glu Ala Leu Ile Gln Asn Leu Asp Asn Val Val 
        755                 760                 765             


Glu Asp Ser Met Leu Val Asp Pro Lys His His Arg His Phe Val Ile 
    770                 775                 780                 


Arg Arg Gly Gln Val Leu Arg Glu Ile Ala Glu Glu Tyr Gly Gly Val 
785                 790                 795                 800 


Met Val Ser Phe Pro Arg Ser Gly Thr Gln Ser Asp Lys Val Thr Leu 
                805                 810                 815     


Lys Gly Ala Lys Asp Cys Val Glu Ala Ala Lys Lys Arg Ile Gln Glu 
            820                 825                 830         


Ile Ile Glu Asp Leu Glu Ala Gln Val Thr Leu Glu Cys Ala Ile Pro 
        835                 840                 845             


Gln Lys Phe His Arg Ser Val Met Gly Pro Lys Gly Ser Arg Ile Gln 
    850                 855                 860                 


Gln Ile Thr Arg Asp Phe Ser Val Gln Ile Lys Phe Pro Asp Arg Glu 
865                 870                 875                 880 


Glu Asn Ala Val His Ser Thr Glu Pro Val Val Gln Glu Asn Gly Asp 
                885                 890                 895     


Glu Ala Gly Glu Gly Arg Glu Ala Lys Asp Cys Asp Pro Gly Ser Pro 
            900                 905                 910         


Arg Arg Cys Asp Ile Ile Ile Ile Ser Gly Arg Lys Glu Lys Cys Glu 
        915                 920                 925             


Ala Ala Lys Glu Ala Leu Glu Ala Leu Val Pro Val Thr Ile Glu Val 
    930                 935                 940                 


Glu Val Pro Phe Asp Leu His Arg Tyr Val Ile Gly Gln Lys Gly Ser 
945                 950                 955                 960 


Gly Ile Arg Lys Met Met Asp Glu Phe Glu Val Asn Ile His Val Pro 
                965                 970                 975     


Ala Pro Glu Leu Gln Ser Asp Ile Ile Ala Ile Thr Gly Leu Ala Ala 
            980                 985                 990         


Asn Leu Asp Arg Ala Lys Ala Gly  Leu Leu Glu Arg Val  Lys Glu Leu 
        995                 1000                 1005             


Gln Ala  Glu Gln Glu Asp Arg  Ala Leu Arg Ser Phe  Lys Leu Ser 
    1010                 1015                 1020             


Val Thr  Val Asp Pro Lys Tyr  His Pro Lys Ile Ile  Gly Arg Lys 
    1025                 1030                 1035             


Gly Ala  Val Ile Thr Gln Ile  Arg Leu Glu His Asp  Val Asn Ile 
    1040                 1045                 1050             


Gln Phe  Pro Asp Lys Asp Asp  Gly Asn Gln Pro Gln  Asp Gln Ile 
    1055                 1060                 1065             


Thr Ile  Thr Gly Tyr Glu Lys  Asn Thr Glu Ala Ala  Arg Asp Ala 
    1070                 1075                 1080             


Ile Leu  Arg Ile Val Gly Glu  Leu Glu Gln Met Val  Ser Glu Asp 
    1085                 1090                 1095             


Val Pro  Leu Asp His Arg Val  His Ala Arg Ile Ile  Gly Ala Arg 
    1100                 1105                 1110             


Gly Lys  Ala Ile Arg Lys Ile  Met Asp Glu Phe Lys  Val Asp Ile 
    1115                 1120                 1125             


Arg Phe  Pro Gln Ser Gly Ala  Pro Asp Pro Asn Cys  Val Thr Val 
    1130                 1135                 1140             


Thr Gly  Leu Pro Glu Asn Val  Glu Glu Ala Ile Asp  His Ile Leu 
    1145                 1150                 1155             


Asn Leu  Glu Glu Glu Tyr Leu  Ala Asp Val Val Asp  Ser Glu Ala 
    1160                 1165                 1170             


Leu Gln  Val Tyr Met Lys Pro  Pro Ala His Glu Glu  Ala Lys Ala 
    1175                 1180                 1185             


Pro Ser  Arg Gly Phe Val Val  Arg Asp Ala Pro Trp  Thr Ala Ser 
    1190                 1195                 1200             


Ser Ser  Glu Lys Ala Pro Asp  Met Ser Ser Ser Glu  Glu Phe Pro 
    1205                 1210                 1215             


Ser Phe  Gly Ala Gln Val Ala  Pro Lys Thr Leu Pro  Trp Gly Pro 
    1220                 1225                 1230             


Lys Arg  
    1235 


<210>  4919
<211>  2144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEATR1__Homo_sapiens__NP_060542

<400>  4919

Met Thr Ser Leu Ala Gln Gln Leu Gln Arg Leu Ala Leu Pro Gln Ser 
1               5                   10                  15      


Asp Ala Ser Leu Leu Ser Arg Asp Glu Val Ala Ser Leu Leu Phe Asp 
            20                  25                  30          


Pro Lys Glu Ala Ala Thr Ile Asp Arg Asp Thr Ala Phe Ala Ile Gly 
        35                  40                  45              


Cys Thr Gly Leu Glu Glu Leu Leu Gly Ile Asp Pro Ser Phe Glu Gln 
    50                  55                  60                  


Phe Glu Ala Pro Leu Phe Ser Gln Leu Ala Lys Thr Leu Glu Arg Ser 
65                  70                  75                  80  


Val Gln Thr Lys Ala Val Asn Lys Gln Leu Asp Glu Asn Ile Ser Leu 
                85                  90                  95      


Phe Leu Ile His Leu Ser Pro Tyr Phe Leu Leu Lys Pro Ala Gln Lys 
            100                 105                 110         


Cys Leu Glu Trp Leu Ile His Arg Phe His Ile His Leu Tyr Asn Gln 
        115                 120                 125             


Asp Ser Leu Ile Ala Cys Val Leu Pro Tyr His Glu Thr Arg Ile Phe 
    130                 135                 140                 


Val Arg Val Ile Gln Leu Leu Lys Ile Asn Asn Ser Lys His Arg Trp 
145                 150                 155                 160 


Phe Trp Leu Leu Pro Val Lys Gln Ser Gly Val Pro Leu Ala Lys Gly 
                165                 170                 175     


Thr Leu Ile Thr His Cys Tyr Lys Asp Leu Gly Phe Met Asp Phe Ile 
            180                 185                 190         


Cys Ser Leu Val Thr Lys Ser Val Lys Val Phe Ala Glu Tyr Pro Gly 
        195                 200                 205             


Ser Ser Ala Gln Leu Arg Val Leu Leu Ala Phe Tyr Ala Ser Thr Ile 
    210                 215                 220                 


Val Ser Ala Leu Val Ala Ala Glu Asp Val Ser Asp Asn Ile Ile Ala 
225                 230                 235                 240 


Lys Leu Phe Pro Tyr Ile Gln Lys Gly Leu Lys Ser Ser Leu Pro Asp 
                245                 250                 255     


Tyr Arg Ala Ala Thr Tyr Met Ile Ile Cys Gln Ile Ser Val Lys Val 
            260                 265                 270         


Thr Met Glu Asn Thr Phe Val Asn Ser Leu Ala Ser Gln Ile Ile Lys 
        275                 280                 285             


Thr Leu Thr Lys Ile Pro Ser Leu Ile Lys Asp Gly Leu Ser Cys Leu 
    290                 295                 300                 


Ile Val Leu Leu Gln Arg Gln Lys Pro Glu Ser Leu Gly Lys Lys Pro 
305                 310                 315                 320 


Phe Pro His Leu Cys Asn Val Pro Asp Leu Ile Thr Ile Leu His Gly 
                325                 330                 335     


Ile Ser Glu Thr Tyr Asp Val Ser Pro Leu Leu His Tyr Met Leu Pro 
            340                 345                 350         


His Leu Val Val Ser Ile Ile His His Val Thr Gly Glu Glu Thr Glu 
        355                 360                 365             


Gly Met Asp Gly Gln Ile Tyr Lys Arg His Leu Glu Ala Ile Leu Thr 
    370                 375                 380                 


Lys Ile Ser Leu Lys Asn Asn Leu Asp His Leu Leu Ala Ser Leu Leu 
385                 390                 395                 400 


Phe Glu Glu Tyr Ile Ser Tyr Ser Ser Gln Glu Glu Met Asp Ser Asn 
                405                 410                 415     


Lys Val Ser Leu Leu Asn Glu Gln Phe Leu Pro Leu Ile Arg Leu Leu 
            420                 425                 430         


Glu Ser Lys Tyr Pro Arg Thr Leu Asp Val Val Leu Glu Glu His Leu 
        435                 440                 445             


Lys Glu Ile Ala Asp Leu Lys Lys Gln Glu Leu Phe His Gln Phe Val 
    450                 455                 460                 


Ser Leu Ser Thr Ser Gly Gly Lys Tyr Gln Phe Leu Ala Asp Ser Asp 
465                 470                 475                 480 


Thr Ser Leu Met Leu Ser Leu Asn His Pro Leu Ala Pro Val Arg Ile 
                485                 490                 495     


Leu Ala Met Asn His Leu Lys Lys Ile Met Lys Thr Ser Lys Glu Gly 
            500                 505                 510         


Val Asp Glu Ser Phe Ile Lys Glu Ala Val Leu Ala Arg Leu Gly Asp 
        515                 520                 525             


Asp Asn Ile Asp Val Val Leu Ser Ala Ile Ser Ala Phe Glu Ile Phe 
    530                 535                 540                 


Lys Glu His Phe Ser Ser Glu Val Thr Ile Ser Asn Leu Leu Asn Leu 
545                 550                 555                 560 


Phe Gln Arg Ala Glu Leu Ser Lys Asn Gly Glu Trp Tyr Glu Val Leu 
                565                 570                 575     


Lys Ile Ala Ala Asp Ile Leu Ile Lys Glu Glu Ile Leu Ser Glu Asn 
            580                 585                 590         


Asp Gln Leu Ser Asn Gln Val Val Val Cys Leu Leu Pro Phe Met Val 
        595                 600                 605             


Ile Asn Asn Asp Asp Thr Glu Ser Ala Glu Met Lys Ile Ala Ile Tyr 
    610                 615                 620                 


Leu Ser Lys Ser Gly Ile Cys Ser Leu His Pro Leu Leu Arg Gly Trp 
625                 630                 635                 640 


Glu Glu Ala Leu Glu Asn Val Ile Lys Ser Thr Lys Pro Gly Lys Leu 
                645                 650                 655     


Ile Gly Val Ala Asn Gln Lys Met Ile Glu Leu Leu Ala Asp Asn Ile 
            660                 665                 670         


Asn Leu Gly Asp Pro Ser Ser Met Leu Lys Met Val Glu Asp Leu Ile 
        675                 680                 685             


Ser Val Gly Glu Glu Glu Ser Phe Asn Leu Lys Gln Lys Val Thr Phe 
    690                 695                 700                 


His Val Ile Leu Ser Val Leu Val Ser Cys Cys Ser Ser Leu Lys Glu 
705                 710                 715                 720 


Thr His Phe Pro Phe Ala Ile Arg Val Phe Ser Leu Leu Gln Lys Lys 
                725                 730                 735     


Ile Lys Lys Leu Glu Ser Val Ile Thr Ala Val Glu Ile Pro Ser Glu 
            740                 745                 750         


Trp His Ile Glu Leu Met Leu Asp Arg Gly Ile Pro Val Glu Leu Trp 
        755                 760                 765             


Ala His Tyr Val Glu Glu Leu Asn Ser Thr Gln Arg Val Ala Val Glu 
    770                 775                 780                 


Asp Ser Val Phe Leu Val Phe Ser Leu Lys Lys Phe Ile Tyr Ala Leu 
785                 790                 795                 800 


Lys Ala Pro Lys Ser Phe Pro Lys Gly Asp Ile Trp Trp Asn Pro Glu 
                805                 810                 815     


Gln Leu Lys Glu Asp Ser Arg Asp Tyr Leu His Leu Leu Ile Gly Leu 
            820                 825                 830         


Phe Glu Met Met Leu Asn Gly Ala Asp Ala Val His Phe Arg Val Leu 
        835                 840                 845             


Met Lys Leu Phe Ile Lys Val His Leu Glu Asp Val Phe Gln Leu Phe 
    850                 855                 860                 


Lys Phe Cys Ser Val Leu Trp Thr Tyr Gly Ser Ser Leu Ser Asn Pro 
865                 870                 875                 880 


Leu Asn Cys Ser Val Lys Thr Val Leu Gln Thr Gln Ala Leu Tyr Val 
                885                 890                 895     


Gly Cys Ala Met Leu Ser Ser Gln Lys Thr Gln Cys Lys His Gln Leu 
            900                 905                 910         


Ala Ser Ile Ser Ser Pro Val Val Thr Ser Leu Leu Ile Asn Leu Gly 
        915                 920                 925             


Ser Pro Val Lys Glu Val Arg Arg Ala Ala Ile Gln Cys Leu Gln Ala 
    930                 935                 940                 


Leu Ser Gly Val Ala Ser Pro Phe Tyr Leu Ile Ile Asp His Leu Ile 
945                 950                 955                 960 


Ser Lys Ala Glu Glu Ile Thr Ser Asp Ala Ala Tyr Val Ile Gln Asp 
                965                 970                 975     


Leu Ala Thr Leu Phe Glu Glu Leu Gln Arg Glu Lys Lys Leu Lys Ser 
            980                 985                 990         


His Gln Lys Leu Ser Glu Thr Leu  Lys Asn Leu Leu Ser  Cys Val Tyr 
        995                 1000                 1005             


Ser Cys  Pro Ser Tyr Ile Ala  Lys Asp Leu Met Lys  Val Leu Gln 
    1010                 1015                 1020             


Gly Val  Asn Gly Glu Met Val  Leu Ser Gln Leu Leu  Pro Met Ala 
    1025                 1030                 1035             


Glu Gln  Leu Leu Glu Lys Ile  Gln Lys Glu Pro Thr  Ala Val Leu 
    1040                 1045                 1050             


Lys Asp  Glu Ala Met Val Leu  His Leu Thr Leu Gly  Lys Tyr Asn 
    1055                 1060                 1065             


Glu Phe  Ser Val Ser Leu Leu  Asn Glu Asp Pro Lys  Ser Leu Asp 
    1070                 1075                 1080             


Ile Phe  Ile Lys Ala Val His  Thr Thr Lys Glu Leu  Tyr Ala Gly 
    1085                 1090                 1095             


Met Pro  Thr Ile Gln Ile Thr  Ala Leu Glu Lys Ile  Thr Lys Pro 
    1100                 1105                 1110             


Phe Phe  Ala Ala Ile Ser Asp  Glu Lys Val Gln Gln  Lys Leu Leu 
    1115                 1120                 1125             


Arg Met  Leu Phe Asp Leu Leu  Val Asn Cys Lys Asn  Ser His Cys 
    1130                 1135                 1140             


Ala Gln  Thr Val Ser Ser Val  Phe Lys Gly Ile Ser  Val Asn Ala 
    1145                 1150                 1155             


Glu Gln  Val Arg Ile Glu Leu  Glu Pro Pro Asp Lys  Ala Lys Pro 
    1160                 1165                 1170             


Leu Gly  Thr Val Gln Gln Lys  Arg Arg Gln Lys Met  Gln Gln Lys 
    1175                 1180                 1185             


Lys Ser  Gln Asp Leu Glu Ser  Val Gln Glu Val Gly  Gly Ser Tyr 
    1190                 1195                 1200             


Trp Gln  Arg Val Thr Leu Ile  Leu Glu Leu Leu Gln  His Lys Lys 
    1205                 1210                 1215             


Lys Leu  Arg Ser Pro Gln Ile  Leu Val Pro Thr Leu  Phe Asn Leu 
    1220                 1225                 1230             


Leu Ser  Arg Cys Leu Glu Pro  Leu Pro Gln Glu Gln  Gly Asn Met 
    1235                 1240                 1245             


Glu Tyr  Thr Lys Gln Leu Ile  Leu Ser Cys Leu Leu  Asn Ile Cys 
    1250                 1255                 1260             


Gln Lys  Leu Ser Pro Asp Gly  Gly Lys Ile Pro Lys  Asp Ile Leu 
    1265                 1270                 1275             


Asp Glu  Glu Lys Phe Asn Val  Glu Leu Ile Val Gln  Cys Ile Arg 
    1280                 1285                 1290             


Leu Ser  Glu Met Pro Gln Thr  His His His Ala Leu  Leu Leu Leu 
    1295                 1300                 1305             


Gly Thr  Val Ala Gly Ile Phe  Pro Asp Lys Val Leu  His Asn Ile 
    1310                 1315                 1320             


Met Ser  Ile Phe Thr Phe Met  Gly Ala Asn Val Met  Arg Leu Asp 
    1325                 1330                 1335             


Asp Thr  Tyr Ser Phe Gln Val  Ile Asn Lys Thr Val  Lys Met Val 
    1340                 1345                 1350             


Ile Pro  Ala Leu Ile Gln Ser  Asp Ser Gly Asp Ser  Ile Glu Val 
    1355                 1360                 1365             


Ser Arg  Asn Val Glu Glu Ile  Val Val Lys Ile Ile  Ser Val Phe 
    1370                 1375                 1380             


Val Asp  Ala Leu Pro His Val  Pro Glu His Arg Arg  Leu Pro Ile 
    1385                 1390                 1395             


Leu Val  Gln Leu Val Asp Thr  Leu Gly Ala Glu Lys  Phe Leu Trp 
    1400                 1405                 1410             


Ile Leu  Leu Ile Leu Leu Phe  Glu Gln Tyr Val Thr  Lys Thr Val 
    1415                 1420                 1425             


Leu Ala  Ala Ala Tyr Gly Glu  Lys Asp Ala Ile Leu  Glu Ala Asp 
    1430                 1435                 1440             


Thr Glu  Phe Trp Phe Ser Val  Cys Cys Glu Phe Ser  Val Gln His 
    1445                 1450                 1455             


Gln Ile  Gln Ser Leu Met Asn  Ile Leu Gln Tyr Leu  Leu Lys Leu 
    1460                 1465                 1470             


Pro Glu  Glu Lys Glu Glu Thr  Ile Pro Lys Ala Val  Ser Phe Asn 
    1475                 1480                 1485             


Lys Ser  Glu Ser Gln Glu Glu  Met Leu Gln Val Phe  Asn Val Glu 
    1490                 1495                 1500             


Thr His  Thr Ser Lys Gln Leu  Arg His Phe Lys Phe  Leu Ser Val 
    1505                 1510                 1515             


Ser Phe  Met Ser Gln Leu Leu  Ser Ser Asn Asn Phe  Leu Lys Lys 
    1520                 1525                 1530             


Val Val  Glu Ser Gly Gly Pro  Glu Ile Leu Lys Gly  Leu Glu Glu 
    1535                 1540                 1545             


Arg Leu  Leu Glu Thr Val Leu  Gly Tyr Ile Ser Ala  Val Ala Gln 
    1550                 1555                 1560             


Ser Met  Glu Arg Asn Ala Asp  Lys Leu Thr Val Lys  Phe Trp Arg 
    1565                 1570                 1575             


Ala Leu  Leu Ser Lys Ala Tyr  Asp Leu Leu Asp Lys  Val Asn Ala 
    1580                 1585                 1590             


Leu Leu  Pro Thr Glu Thr Phe  Ile Pro Val Ile Arg  Gly Leu Val 
    1595                 1600                 1605             


Gly Asn  Pro Leu Pro Ser Val  Arg Arg Lys Ala Leu  Asp Leu Leu 
    1610                 1615                 1620             


Asn Asn  Lys Leu Gln Gln Asn  Ile Ser Trp Lys Lys  Thr Ile Val 
    1625                 1630                 1635             


Thr Arg  Phe Leu Lys Leu Val  Pro Asp Leu Leu Ala  Ile Val Gln 
    1640                 1645                 1650             


Arg Lys  Lys Lys Glu Gly Glu  Glu Glu Gln Ala Ile  Asn Arg Gln 
    1655                 1660                 1665             


Thr Ala  Leu Tyr Thr Leu Lys  Leu Leu Cys Lys Asn  Phe Gly Ala 
    1670                 1675                 1680             


Glu Asn  Pro Asp Pro Phe Val  Pro Val Leu Asn Thr  Ala Val Lys 
    1685                 1690                 1695             


Leu Ile  Ala Pro Glu Arg Lys  Glu Glu Lys Asn Val  Leu Gly Ser 
    1700                 1705                 1710             


Ala Leu  Leu Cys Ile Ala Glu  Val Thr Ser Thr Leu  Glu Ala Leu 
    1715                 1720                 1725             


Ala Ile  Pro Gln Leu Pro Ser  Leu Met Pro Ser Leu  Leu Thr Thr 
    1730                 1735                 1740             


Met Lys  Asn Thr Ser Glu Leu  Val Ser Ser Glu Val  Tyr Leu Leu 
    1745                 1750                 1755             


Ser Ala  Leu Ala Ala Leu Gln  Lys Val Val Glu Thr  Leu Pro His 
    1760                 1765                 1770             


Phe Ile  Ser Pro Tyr Leu Glu  Gly Ile Leu Ser Gln  Val Ile His 
    1775                 1780                 1785             


Leu Glu  Lys Ile Thr Ser Glu  Met Gly Ser Ala Ser  Gln Ala Asn 
    1790                 1795                 1800             


Ile Arg  Leu Thr Ser Leu Lys  Lys Thr Leu Ala Thr  Thr Leu Ala 
    1805                 1810                 1815             


Pro Arg  Val Leu Leu Pro Ala  Ile Lys Lys Thr Tyr  Lys Gln Ile 
    1820                 1825                 1830             


Glu Lys  Asn Trp Lys Asn His  Met Gly Pro Phe Met  Ser Ile Leu 
    1835                 1840                 1845             


Gln Glu  His Ile Gly Val Met  Lys Lys Glu Glu Leu  Thr Ser His 
    1850                 1855                 1860             


Gln Ser  Gln Leu Thr Ala Phe  Phe Leu Glu Ala Leu  Asp Phe Arg 
    1865                 1870                 1875             


Ala Gln  His Ser Glu Asn Asp  Leu Glu Glu Val Gly  Lys Thr Glu 
    1880                 1885                 1890             


Asn Cys  Ile Ile Asp Cys Leu  Val Ala Met Val Val  Lys Leu Ser 
    1895                 1900                 1905             


Glu Val  Thr Phe Arg Pro Leu  Phe Phe Lys Leu Phe  Asp Trp Ala 
    1910                 1915                 1920             


Lys Thr  Glu Asp Ala Pro Lys  Asp Arg Leu Leu Thr  Phe Tyr Asn 
    1925                 1930                 1935             


Leu Ala  Asp Cys Ile Ala Glu  Lys Leu Lys Gly Leu  Phe Thr Leu 
    1940                 1945                 1950             


Phe Ala  Gly His Leu Val Lys  Pro Phe Ala Asp Thr  Leu Asn Gln 
    1955                 1960                 1965             


Val Asn  Ile Ser Lys Thr Asp  Glu Ala Phe Phe Asp  Ser Glu Asn 
    1970                 1975                 1980             


Asp Pro  Glu Lys Cys Cys Leu  Leu Leu Gln Phe Ile  Leu Asn Cys 
    1985                 1990                 1995             


Leu Tyr  Lys Ile Phe Leu Phe  Asp Thr Gln His Phe  Ile Ser Lys 
    2000                 2005                 2010             


Glu Arg  Ala Glu Ala Leu Met  Met Pro Leu Val Asp  Gln Leu Glu 
    2015                 2020                 2025             


Asn Arg  Leu Gly Gly Glu Glu  Lys Phe Gln Glu Arg  Val Thr Lys 
    2030                 2035                 2040             


His Leu  Ile Pro Cys Ile Ala  Gln Phe Ser Val Ala  Met Ala Asp 
    2045                 2050                 2055             


Asp Ser  Leu Trp Lys Pro Leu  Asn Tyr Gln Ile Leu  Leu Lys Thr 
    2060                 2065                 2070             


Arg Asp  Ser Ser Pro Lys Val  Arg Phe Ala Ala Leu  Ile Thr Val 
    2075                 2080                 2085             


Leu Ala  Leu Ala Glu Lys Leu  Lys Glu Asn Tyr Ile  Val Leu Leu 
    2090                 2095                 2100             


Pro Glu  Ser Ile Pro Phe Leu  Ala Glu Leu Met Glu  Asp Glu Cys 
    2105                 2110                 2115             


Glu Glu  Val Glu His Gln Cys  Gln Lys Thr Ile Gln  Gln Leu Glu 
    2120                 2125                 2130             


Thr Val  Leu Gly Glu Pro Leu  Gln Ser Tyr Phe 
    2135                 2140                 


<210>  4920
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEATR3__Homo_sapiens__NP_891552

<400>  4920

Met Gly Lys Ser Arg Thr Lys Arg Phe Lys Arg Pro Gln Phe Ser Pro 
1               5                   10                  15      


Thr Gly Asp Cys Gln Ala Glu Ala Ala Ala Ala Ala Asn Gly Thr Gly 
            20                  25                  30          


Gly Glu Glu Asp Asp Gly Pro Ala Ala Glu Leu Leu Glu Lys Leu Gln 
        35                  40                  45              


His Pro Ser Ala Glu Val Arg Glu Cys Ala Cys Ala Gly Leu Ala Arg 
    50                  55                  60                  


Leu Val Gln Gln Arg Pro Ala Leu Pro Gly Leu Ala Arg Arg Asp Ala 
65                  70                  75                  80  


Val Arg Arg Leu Gly Pro Leu Leu Leu Asp Pro Ser Leu Ala Val Arg 
                85                  90                  95      


Glu Thr Ala Ala Gly Ala Leu Arg Asn Leu Ser Ala Cys Gly Gly Phe 
            100                 105                 110         


Glu Val Cys Asp Asp Met Val Thr Lys Asp Ile Met Thr Pro Leu Val 
        115                 120                 125             


Ala Leu Leu Lys Glu Cys Ser Ala Gly Leu Asp Ser Asn Glu Met Ser 
    130                 135                 140                 


Leu Gln Glu Lys Lys Asp Gln Asn Arg Asn Ser Ile Glu Asn Ile Ala 
145                 150                 155                 160 


Asn Glu Thr Val Asn Val Leu Trp Asn Ile Cys Glu Cys Ser Ser Arg 
                165                 170                 175     


Ala Val Ser Ile Phe Asn Lys Glu Gly Cys Leu Glu Ile Val Leu Lys 
            180                 185                 190         


Tyr Leu Ser Arg Phe Pro Thr Asn Val Asp Leu Ala Ile Ser Val Ala 
        195                 200                 205             


Tyr Cys Leu Gln Thr Val Thr Glu Asp Asn Pro Glu Leu Leu Lys Ser 
    210                 215                 220                 


Phe Ser Ala Thr Ala Leu Asn Met Leu Glu Ser Ala Leu Leu Ser Pro 
225                 230                 235                 240 


Val Ser Ser Met Glu Ser Leu Leu Leu Lys Thr Leu Val Ala Gly Thr 
                245                 250                 255     


Ile Trp Asn Leu Lys Asp Ile Ile Pro Cys Lys Ser Gln Ala Glu Ile 
            260                 265                 270         


Ile Asn Ala Leu Leu Lys Ile Leu Ser Glu Val Leu Gly Met Asp Ala 
        275                 280                 285             


Gly Glu Met Val Ile Gln Met Lys Glu Ala Glu Thr Gln Arg Leu Lys 
    290                 295                 300                 


Thr Ala Ala Glu Ala Glu Glu Ile Leu Glu Asn Thr Asn Gly Asp Asp 
305                 310                 315                 320 


Leu Ile Glu Asp Asp Glu Met Glu Gly Ile Ser His Lys Arg Arg Val 
                325                 330                 335     


Arg Arg Lys Thr Phe Val Ser Asp Leu Leu Pro Pro Thr Asp Lys Glu 
            340                 345                 350         


Leu Arg Glu Thr Ile Ala Leu Leu Thr Ala Gln Gln Thr Ala Leu Glu 
        355                 360                 365             


Ile Ile Val Asn Met Cys Cys Asn Glu Asp Pro Ser Asp Asp Glu Trp 
    370                 375                 380                 


Glu Glu Leu Ser Ser Ser Asp Glu Ser Asp Ala Phe Met Glu Asn Ser 
385                 390                 395                 400 


Phe Ser Glu Cys Gly Gly Gln Leu Phe Ser Pro Leu Cys Leu Ser His 
                405                 410                 415     


Glu Val His Thr Ala Leu Thr Asn Tyr Leu Ile Pro Lys Lys Ile Phe 
            420                 425                 430         


Glu Lys Thr Ala Phe Pro Asn Ser Ile Ala Val Asp Leu Cys Ser Arg 
        435                 440                 445             


Asn Pro Thr Trp Lys Pro Leu Ile Arg Lys Met Asn Thr Ile Gln Cys 
    450                 455                 460                 


Arg Ala Leu Phe Cys Leu Gln Ser Leu Val Ser Leu Leu Asp Val Glu 
465                 470                 475                 480 


His Leu Gly Gly Ala Ala Ala Leu Gln Thr Leu Ala Gln His Leu Ser 
                485                 490                 495     


Gln Leu Leu Phe Ser Gln Pro Asp Phe Ala Lys His Val Asp Phe Leu 
            500                 505                 510         


Glu Ala Ile Ser Ser Ala Leu Arg Ala Leu Leu Gln Thr Met Ala Ser 
        515                 520                 525             


Lys Asn Ile Ser Gln Cys Met Thr Pro Asp Gln Leu Met Thr Leu Cys 
    530                 535                 540                 


Lys Ala Gly Ile His Ser Ser Asn Val Gly Val Arg Val Asn Val Val 
545                 550                 555                 560 


Ser Ile Leu Gly Ile Thr Gly Ser Val Leu Ala Lys Glu Asp Gly Thr 
                565                 570                 575     


Leu Glu Thr Leu Lys Asn Ile Gly Cys Phe Leu Leu Glu Val Thr Thr 
            580                 585                 590         


Lys Asp Pro Ser Leu Val Val Ala Gly Glu Ala Leu Asp Ala Leu Phe 
        595                 600                 605             


Asp Val Phe Ala Asp Gly Lys Glu Ala Glu Arg Ala Ser Ile Gln Ile 
    610                 615                 620                 


Lys Leu Leu Ser Ala Leu Lys Glu Phe Gln Pro Val Phe Lys Met Lys 
625                 630                 635                 640 


Ile Arg Lys Glu Gly Arg Gly Asn Tyr Ser Thr Asp Gln Leu Cys Val 
                645                 650                 655     


Leu Asp Asn Val Lys Met Asn Leu Arg Arg Phe Ile Ala Tyr Gln Glu 
            660                 665                 670         


Thr Val Glu Lys Arg Leu Thr Ser 
        675                 680 


<210>  4921
<211>  2071
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEATR5B__Homo_sapiens__NP_061897

<400>  4921

Met Glu Leu Ala His Ser Leu Leu Leu Asn Glu Glu Ala Leu Ala Gln 
1               5                   10                  15      


Ile Thr Glu Ala Lys Arg Pro Val Phe Ile Phe Glu Trp Leu Arg Phe 
            20                  25                  30          


Leu Asp Lys Val Leu Val Ala Ala Asn Lys Thr Asp Val Lys Glu Lys 
        35                  40                  45              


Gln Lys Lys Leu Val Glu Gln Leu Thr Gly Leu Ile Ser Ser Ser Pro 
    50                  55                  60                  


Gly Pro Pro Thr Arg Lys Leu Leu Ala Lys Asn Leu Ala Ala Leu Tyr 
65                  70                  75                  80  


Ser Ile Gly Asp Thr Phe Thr Val Phe Gln Thr Leu Asp Lys Cys Asn 
                85                  90                  95      


Asp Ile Ile Arg Asn Lys Asp Asp Thr Ala Ala Tyr Leu Pro Thr Lys 
            100                 105                 110         


Leu Ala Ala Val Ala Cys Val Gly Ala Phe Tyr Glu Lys Met Gly Arg 
        115                 120                 125             


Met Leu Gly Ser Ala Phe Pro Glu Thr Val Asn Asn Leu Leu Lys Ser 
    130                 135                 140                 


Leu Lys Ser Ala Glu Ser Gln Gly Arg Ser Glu Ile Leu Met Ser Leu 
145                 150                 155                 160 


Gln Lys Val Leu Ser Gly Leu Gly Gly Ala Ala Ala Ser Ser His Arg 
                165                 170                 175     


Asp Ile Tyr Lys Asn Ala Arg Ser Leu Leu Thr Asp Arg Ser Met Ala 
            180                 185                 190         


Val Arg Cys Ala Val Ala Lys Cys Leu Leu Glu Leu Gln Asn Glu Ala 
        195                 200                 205             


Val Phe Met Trp Thr Ala Glu Leu Glu Asn Ile Ala Thr Leu Cys Phe 
    210                 215                 220                 


Lys Ala Leu Glu Asn Ser Asn Tyr Gly Val Arg Val Ala Val Ser Lys 
225                 230                 235                 240 


Leu Leu Gly Thr Val Met Ala Thr Ala Leu Met Pro Lys Gln Ala Thr 
                245                 250                 255     


Val Met Arg Gln Asn Val Lys Arg Ala Thr Phe Asp Glu Val Leu Glu 
            260                 265                 270         


Leu Met Ala Thr Gly Phe Leu Arg Gly Gly Ser Gly Phe Leu Lys Ser 
        275                 280                 285             


Gly Gly Glu Met Leu Lys Val Gly Gly Ser Val Asn Arg Glu Val Arg 
    290                 295                 300                 


Val Gly Val Thr Gln Ala Tyr Val Val Phe Val Thr Thr Leu Gly Gly 
305                 310                 315                 320 


Gln Trp Leu Glu Arg Ser Phe Ala Thr Phe Leu Ser His Val Leu Asp 
                325                 330                 335     


Leu Val Ser His Pro Arg Ala Thr Gln Thr His Val Glu Ala Val Tyr 
            340                 345                 350         


Ser Arg Arg Cys Val Ser Phe Ile Leu Arg Ala Thr Val Gly Ser Leu 
        355                 360                 365             


Leu Gly Glu Lys Ala Gln Ile Ala Ala Ala Lys Glu Ile Cys Gln Ala 
    370                 375                 380                 


Ile Gly Lys Gln Met Lys Ala Val Glu Ala Val Val Asn Asp Thr Ser 
385                 390                 395                 400 


Gly Glu Asn Lys Ser Gly Ala Ala Asp Ile Ala Ala Ser Gln His Val 
                405                 410                 415     


Met Val Cys Ala Leu Gln Glu Leu Gly Ser Leu Val Gln Ser Leu Asn 
            420                 425                 430         


Ala Thr Ala Ser Pro Leu Ile Gln Glu Ala Ser Ile Gly Leu Leu Glu 
        435                 440                 445             


Ile Val Thr Ser Val Leu Leu His Pro Ser Met Ala Ala Arg Leu Ala 
    450                 455                 460                 


Ala Ala Trp Cys Leu Arg Cys Val Ala Val Ala Leu Pro Phe Gln Leu 
465                 470                 475                 480 


Thr Pro Phe Leu Asp Arg Cys Ala Glu Arg Leu Asn Asn Leu Lys Thr 
                485                 490                 495     


Ser Pro Glu Ala Val Ser Gly Tyr Ser Phe Ala Met Ala Ala Leu Leu 
            500                 505                 510         


Gly Gly Val His Gln Cys Pro Leu Gly Ile Pro His Ala Lys Gly Lys 
        515                 520                 525             


Met Val Val Ser Ile Ala Glu Asp Leu Leu Arg Thr Ala Ala Gln Asn 
    530                 535                 540                 


Ser Arg Leu Ser Leu Gln Arg Thr Gln Ala Gly Trp Leu Leu Leu Gly 
545                 550                 555                 560 


Ala Leu Met Thr Leu Gly Pro Ser Val Val Arg Tyr His Leu Pro Lys 
                565                 570                 575     


Met Leu Leu Leu Trp Arg Asn Val Phe Pro Arg Ser Leu Lys Glu Leu 
            580                 585                 590         


Glu Ala Glu Lys Ala Arg Gly Asp Ser Phe Thr Trp Gln Val Thr Leu 
        595                 600                 605             


Glu Gly Arg Ala Gly Ala Leu Cys Ala Met Arg Ser Phe Val Ala His 
    610                 615                 620                 


Cys Pro Glu Leu Leu Thr Glu Asp Val Ile Arg Lys Leu Met Thr Pro 
625                 630                 635                 640 


Ile Glu Cys Ala Met Thr Met Met Ser His Ile Pro Ser Val Met Lys 
                645                 650                 655     


Ala His Gly Ala His Leu Lys Ala Ser Ala Ala Met Val Arg Leu Arg 
            660                 665                 670         


Leu Tyr Asp Ile Leu Ala Leu Leu Pro Pro Lys Thr Tyr Glu Gly Ser 
        675                 680                 685             


Phe Asn Ala Leu Leu Arg Glu Leu Val Ala Glu Phe Thr Leu Thr Asp 
    690                 695                 700                 


Asn Ser Ala Asn Thr Thr Thr Ser Leu Leu Arg Ser Leu Cys His Tyr 
705                 710                 715                 720 


Asp Asp Ser Val Leu Leu Gly Ser Trp Leu Gln Glu Thr Asp His Lys 
                725                 730                 735     


Ser Ile Glu Asp Gln Leu Gln Pro Asn Ser Ala Ser Gly Ser Gly Ala 
            740                 745                 750         


Leu Glu His Asp Pro Ser Ser Ile Tyr Leu Arg Ile Pro Ala Gly Glu 
        755                 760                 765             


Ala Val Pro Gly Pro Leu Pro Leu Gly Val Ser Val Ile Asp Ala Ser 
    770                 775                 780                 


Val Ala Leu Phe Gly Val Val Phe Pro His Val Ser Tyr Lys His Arg 
785                 790                 795                 800 


Leu Gln Met Leu Asp His Phe Ala Glu Cys Val Lys Gln Ala Lys Gly 
                805                 810                 815     


Val Arg Gln Gln Ala Val Gln Leu Asn Ile Phe Thr Ala Val Leu Ser 
            820                 825                 830         


Ala Leu Lys Gly Leu Ala Glu Asn Lys Ser Thr Leu Gly Pro Glu Glu 
        835                 840                 845             


Val Arg Lys Ser Ala Leu Thr Leu Val Met Gly Pro Leu Asp Asn Pro 
    850                 855                 860                 


Asn Pro Ile Leu Arg Cys Ala Ala Gly Glu Ala Leu Gly Arg Met Ala 
865                 870                 875                 880 


Gln Val Val Gly Glu Ala Thr Phe Ile Ala Arg Met Ala Gln Tyr Ser 
                885                 890                 895     


Phe Asp Lys Leu Lys Ser Ala Arg Asp Val Val Ser Arg Thr Gly His 
            900                 905                 910         


Ser Leu Ala Leu Gly Cys Leu His Arg Tyr Val Gly Gly Ile Gly Ser 
        915                 920                 925             


Gly Gln His Leu Lys Thr Ser Val Ser Ile Leu Leu Ala Leu Ala Gln 
    930                 935                 940                 


Asp Gly Thr Ser Pro Glu Val Gln Thr Trp Ser Leu His Ser Leu Ala 
945                 950                 955                 960 


Leu Ile Val Asp Ser Ser Gly Pro Met Tyr Arg Gly Tyr Val Glu Pro 
                965                 970                 975     


Thr Leu Ser Leu Val Leu Thr Leu Leu Leu Thr Val Pro Pro Ser His 
            980                 985                 990         


Thr Glu Val His Gln Cys Leu Gly  Arg Cys Leu Gly Ala  Ile Ile Thr 
        995                 1000                 1005             


Thr Val  Gly Pro Glu Leu Gln  Gly Asn Gly Ala Thr  Thr Ser Thr 
    1010                 1015                 1020             


Ile Arg  Ser Ser Cys Leu Val  Gly Cys Ala Ile Thr  Gln Asp His 
    1025                 1030                 1035             


Ser Asp  Ser Leu Val Gln Ala  Ala Ala Ile Ser Cys  Leu Gln Gln 
    1040                 1045                 1050             


Leu His  Met Phe Ala Pro Arg  His Val Asn Leu Ser  Ser Leu Val 
    1055                 1060                 1065             


Pro Ser  Leu Cys Val His Leu  Cys Ser Ser His Leu  Leu Leu Arg 
    1070                 1075                 1080             


Arg Ala  Ala Val Ala Cys Leu  Arg Gln Leu Ala Gln  Arg Glu Ala 
    1085                 1090                 1095             


Ala Glu  Val Cys Glu Tyr Ala  Met Ser Leu Ala Lys  Asn Thr Gly 
    1100                 1105                 1110             


Asp Lys  Glu Ser Ser Ser Ala  Asn Val Ser Pro Phe  Ala Pro Gly 
    1115                 1120                 1125             


Val Ser  Ser Arg Thr Asp Ile  His Cys Arg His Gln  Gly Val Asn 
    1130                 1135                 1140             


Ile Thr  Glu Thr Gly Leu Glu  Gly Leu Leu Phe Gly  Met Leu Asp 
    1145                 1150                 1155             


Arg Glu  Thr Asp Arg Lys Leu  Cys Ser Asp Ile His  Asp Thr Leu 
    1160                 1165                 1170             


Gly His  Met Leu Ser Ser Leu  Ala Val Glu Lys Leu  Ser His Trp 
    1175                 1180                 1185             


Leu Met  Leu Cys Lys Asp Val  Leu Ala Ala Ser Ser  Asp Met Ser 
    1190                 1195                 1200             


Thr Ala  Thr Leu Leu Ser Ser  Gly Lys Asp Glu Glu  Ala Glu Lys 
    1205                 1210                 1215             


Lys Asp  Glu Met Asp Asp Asp  Thr Met Phe Thr Thr  Leu Gly Glu 
    1220                 1225                 1230             


Glu Asp  Lys Ser Lys Pro Phe  Val Ala Pro Arg Trp  Ala Thr Arg 
    1235                 1240                 1245             


Val Phe  Ala Ala Asp Cys Leu  Cys Arg Ile Ile Asn  Leu Cys Glu 
    1250                 1255                 1260             


Asn Ala  Asp Gln Ala His Phe  Asp Leu Ala Leu Ala  Arg Ser Ala 
    1265                 1270                 1275             


Lys Leu  Arg Asn Pro Thr Asn  Asp Leu Leu Val Leu  His Leu Ser 
    1280                 1285                 1290             


Asp Leu  Ile Arg Met Ala Phe  Met Ala Ala Thr Asp  His Ser Asn 
    1295                 1300                 1305             


Gln Leu  Arg Met Ala Gly Leu  Gln Ala Leu Glu Asp  Ile Ile Lys 
    1310                 1315                 1320             


Lys Phe  Ala Ser Val Pro Glu  Pro Glu Phe Pro Gly  His Val Ile 
    1325                 1330                 1335             


Leu Glu  Gln Tyr Gln Ala Asn  Val Gly Ala Ala Leu  Arg Pro Ala 
    1340                 1345                 1350             


Phe Ser  Gln Asp Thr Pro Ser  Asp Ile Ile Ala Lys  Ala Cys Gln 
    1355                 1360                 1365             


Val Cys  Ser Thr Trp Ile Gly  Ser Gly Val Val Ser  Asp Leu Asn 
    1370                 1375                 1380             


Asp Leu  Arg Arg Val His Asn  Leu Leu Val Ser Ser  Leu Asp Lys 
    1385                 1390                 1395             


Val Gln  Ala Gly Lys Gly Ser  Ser Ser Gln Leu Tyr  Arg Glu Ser 
    1400                 1405                 1410             


Ala Thr  Thr Met Glu Lys Leu  Ala Val Leu Lys Ala  Trp Ala Glu 
    1415                 1420                 1425             


Val Tyr  Val Val Ala Met Asn  Ile Lys Lys Glu Ala  Glu Ser Lys 
    1430                 1435                 1440             


Pro Lys  Arg Ala Ile Lys Asn  Thr Asp Asp Asp Asp  Asp Asp Cys 
    1445                 1450                 1455             


Gly Thr  Ile Asp Glu Leu Pro  Pro Asp Ser Leu Ile  Thr Leu Val 
    1460                 1465                 1470             


Gln Pro  Glu Leu Pro Thr Leu  Ser Arg Leu Trp Leu  Ala Ala Leu 
    1475                 1480                 1485             


Lys Asp  Tyr Ala Leu Leu Thr  Leu Pro Ala Glu Phe  Ser Ser Gln 
    1490                 1495                 1500             


Leu Pro  Pro Asp Gly Gly Ala  Phe Tyr Thr Pro Glu  Thr Ile Asp 
    1505                 1510                 1515             


Thr Ala  Arg Leu His Tyr Arg  Asn Ser Trp Ala Pro  Ile Leu His 
    1520                 1525                 1530             


Ala Val  Ala Leu Trp Leu Asn  Ser Thr Gly Phe Thr  Cys Ser Glu 
    1535                 1540                 1545             


Ser Thr  Glu Ala Ala Ala Ile  Ser Gly Leu Gln Lys  Arg Ser Thr 
    1550                 1555                 1560             


Ser Val  Asn Leu Asn Gln Ala  Ser Gly Ala Val Gly  Ser Ala Lys 
    1565                 1570                 1575             


Ser Leu  Pro Glu Ile Asn Lys  Asp Arg Met His Leu  Ile Leu Gly 
    1580                 1585                 1590             


Val Ser  Ile Gln Phe Leu Cys  Ser Pro Arg Pro Glu  Glu Pro Ile 
    1595                 1600                 1605             


Glu His  Val Thr Ala Cys Leu  Gln Ala Leu His Thr  Leu Leu Asp 
    1610                 1615                 1620             


Ser Pro  Tyr Ala Arg Val His  Ile Ala Glu Asp Gln  Leu Ile Gly 
    1625                 1630                 1635             


Val Glu  Leu Leu Ser Val Leu  His Arg Leu Leu Leu  Thr Trp Asn 
    1640                 1645                 1650             


Pro Ser  Ser Val Gln Leu Leu  Val Thr Gly Val Val  Gln Gln Ile 
    1655                 1660                 1665             


Val Arg  Ala Ala Gln Asp Tyr  Leu Gln Glu Lys Arg  Asn Thr Leu 
    1670                 1675                 1680             


Asn Glu  Asp Asp Met Glu Lys  Glu Ala Cys Thr Val  Leu Gly Glu 
    1685                 1690                 1695             


Gly Gly  Asp Ser Gly Gly Leu  Ile Pro Gly Lys Ser  Leu Val Phe 
    1700                 1705                 1710             


Ala Thr  Met Glu Leu Leu Met  Phe Ile Leu Val Arg  His Met Pro 
    1715                 1720                 1725             


His Leu  Ser Thr Lys Val Ser  Asp Ser Pro Ser His  Ile Ala Thr 
    1730                 1735                 1740             


Lys Thr  Arg Leu Ser Glu Glu  Ser Ala Arg Leu Val  Ala Ala Thr 
    1745                 1750                 1755             


Val Thr  Ile Leu Ser Asp Leu  Pro Ser Leu Cys Ser  Pro Ala Gly 
    1760                 1765                 1770             


Cys Met  Thr Ile Leu Pro Thr  Ile Leu Phe Leu Ile  Ala Arg Ile 
    1775                 1780                 1785             


Leu Lys  Asp Thr Ala Ile Lys  Ser Ala Asp Asn Gln  Val Pro Pro 
    1790                 1795                 1800             


Pro Val  Ser Ala Ala Leu Gln  Gly Ile Lys Ser Ile  Val Thr Leu 
    1805                 1810                 1815             


Ser Met  Ala Lys Thr Glu Ala  Gly Val Gln Lys Gln  Trp Thr Ala 
    1820                 1825                 1830             


Leu Ile  Arg Ser Thr Leu Ala  Cys Ile Leu Glu Tyr  Ser Gln Pro 
    1835                 1840                 1845             


Glu Asp  Ser Val Pro Thr Pro  Asp Glu Val Ser Met  Leu Thr Ala 
    1850                 1855                 1860             


Ile Ala  Leu Phe Leu Trp Ser  Ala Ser Asn Glu Ile  Ile Gly Val 
    1865                 1870                 1875             


Gln Ser  Leu Gln Asn Gly Cys  Met Asn Arg Phe Lys  Asn Ala Leu 
    1880                 1885                 1890             


Asn Ser  Cys Asp Pro Trp Val  Gln Ala Lys Cys Tyr  Gln Leu Leu 
    1895                 1900                 1905             


Leu Ser  Val Phe Gln His Ser  Asn Arg Ala Leu Ser  Thr Pro Tyr 
    1910                 1915                 1920             


Ile His  Ser Leu Ala Pro Ile  Val Val Glu Lys Leu  Lys Ala Val 
    1925                 1930                 1935             


Glu Arg  Asn Arg Pro Ala Ser  Asn Ile Glu Leu Leu  Ala Val Gln 
    1940                 1945                 1950             


Glu Gly  Ile Lys Val Leu Glu  Thr Leu Val Ala Leu  Gly Glu Glu 
    1955                 1960                 1965             


Gln Asn  Arg Val Gln Leu Leu  Ala Leu Leu Val Pro  Thr Leu Ile 
    1970                 1975                 1980             


Ser Tyr  Leu Leu Asp Glu Asn  Ser Phe Ala Ser Ala  Ser Ser Ala 
    1985                 1990                 1995             


Ser Lys  Asp Leu His Glu Phe  Ala Leu Gln Asn Leu  Met His Ile 
    2000                 2005                 2010             


Gly Pro  Leu Tyr Pro His Ala  Phe Lys Thr Val Met  Gly Ala Ala 
    2015                 2020                 2025             


Pro Glu  Leu Lys Val Arg Leu  Glu Thr Ala Val Arg  Ala Ser Gln 
    2030                 2035                 2040             


Ala Ser  Lys Ala Lys Ala Ala  Ala Arg Gln Pro Ala  Pro Ala Ile 
    2045                 2050                 2055             


His Ser  Ala Pro Thr Ile Lys  Leu Lys Thr Ser Phe  Phe 
    2060                 2065                 2070     


<210>  4922
<211>  1181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEATR6__Homo_sapiens__NP_071353

<400>  4922

Met Ala Ala Val Gln Val Val Gly Ser Trp Pro Ser Val Gln Pro Arg 
1               5                   10                  15      


Glu Ala Pro Arg Glu Ala Ile Pro Glu Arg Gly Asn Gly Phe Arg Leu 
            20                  25                  30          


Leu Ser Ala Arg Leu Cys Ala Leu Arg Pro Asp Asp Ser Ser Ser Ala 
        35                  40                  45              


Arg Thr Glu Ile His Leu Leu Phe Asp Gln Leu Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Glu Gly Ser Gly Val Ala Pro Glu Asp Val Ser Ala Leu Leu Val 
65                  70                  75                  80  


Gln Ala Cys Arg Leu Val Pro Leu Asn Gln Asn His Leu Val Ser Lys 
                85                  90                  95      


Val Ser Gln Leu Ile His His Leu Leu Asn Arg Leu Gln Val Ile Val 
            100                 105                 110         


Asp Glu Gln His Leu Asp Phe Leu Leu Ala Tyr Thr Ile Ser Ala Ile 
        115                 120                 125             


His Gln Cys Ser Ser Trp Thr His Arg Glu Ile Leu Gln Ala Leu Ala 
    130                 135                 140                 


Ala Leu Val Tyr Cys Asn Gly Ser Lys Cys Gln Lys Tyr Leu Pro Glu 
145                 150                 155                 160 


Leu Leu Gly Asn Thr Gly Leu Leu Met Lys Leu Ser Asp Leu Ala Gln 
                165                 170                 175     


Ser Asp Pro Glu Val Arg Arg Ala Ala Val His Cys Met Ala Asn Leu 
            180                 185                 190         


Cys Leu Ser Val Pro Gly Gln Pro Tyr Leu Glu Glu Pro Tyr Gln Asn 
        195                 200                 205             


Val Cys Phe Gln Ala Phe Leu Thr Ile Leu Gln Ser Pro Lys Ser Ser 
    210                 215                 220                 


Asp Met Asp Asp Ile Thr Phe Cys Met Leu Leu Gln Asn Ala Leu Lys 
225                 230                 235                 240 


Gly Ile Gln Ser Leu Leu Asn Gly Gly Arg Met Lys Leu Thr Gln Thr 
                245                 250                 255     


Asp Glu Leu Gly Ala Leu Leu Ala Val Leu Lys Lys Phe Met Phe His 
            260                 265                 270         


Gly Leu Pro Gly Leu Asn Ile Glu Met Pro Thr Val Leu Tyr Pro Thr 
        275                 280                 285             


Pro Leu Pro Gln Tyr Asp Gly Arg Thr Pro Ile Lys Pro Gln Gln Ser 
    290                 295                 300                 


Glu Ser Ser Ala Ser Arg Pro Thr Leu Asn Lys Lys Lys Lys Ser Lys 
305                 310                 315                 320 


Val Lys Pro Lys Lys Ile Gln Gln Gly Glu Glu Glu Glu Lys Glu Ser 
                325                 330                 335     


Ser Gly Glu Ile Glu Ala Ala Pro Val Thr Gly Thr Gly Arg Val Asn 
            340                 345                 350         


Leu His Glu Gly Asn Thr Trp Cys Pro Ser Ser Leu Gly Val Gln Ser 
        355                 360                 365             


Leu Pro Leu Asp Gly Ser Gly Ala Ala Glu Lys Asp Gly Val Ser Ser 
    370                 375                 380                 


Ser Phe Ser Ser Ser Ser Trp Lys Arg Val Ser Ser Ser Glu Ser Asp 
385                 390                 395                 400 


Phe Ser Asp Ala Glu Gly Gly Met Gln Ser Lys Met Arg Ser Tyr Gln 
                405                 410                 415     


Ala Lys Val Arg Gln Gly Ala Leu Val Cys Phe Leu Ser Thr Ile Lys 
            420                 425                 430         


Ser Ile Glu Lys Lys Val Leu Tyr Gly Tyr Trp Ser Ala Phe Ile Pro 
        435                 440                 445             


Asp Thr Pro Glu Leu Gly Ser Pro Gln Ser Val Ser Leu Met Thr Leu 
    450                 455                 460                 


Thr Leu Lys Asp Pro Ser Pro Lys Thr Arg Ala Cys Ala Leu Gln Val 
465                 470                 475                 480 


Leu Ser Ala Ile Leu Glu Gly Ser Lys Gln Phe Leu Ser Val Ala Glu 
                485                 490                 495     


Asp Thr Ser Asp His Arg Arg Ala Phe Thr Pro Phe Ser Val Met Ile 
            500                 505                 510         


Ala Cys Ser Ile Arg Glu Leu His Arg Cys Leu Leu Leu Ala Leu Val 
        515                 520                 525             


Ala Glu Ser Ser Ser Gln Thr Val Thr Gln Ile Ile Lys Cys Leu Ala 
    530                 535                 540                 


Asn Leu Val Ser Asn Ala Pro Tyr Asp Arg Leu Lys Leu Ser Leu Leu 
545                 550                 555                 560 


Thr Lys Val Trp Asn Gln Ile Lys Pro Tyr Ile Arg His Lys Asp Val 
                565                 570                 575     


Asn Val Arg Val Ser Ser Leu Thr Leu Leu Gly Ala Ile Val Ser Thr 
            580                 585                 590         


His Ala Pro Leu Pro Glu Val Gln Leu Leu Leu Gln Gln Pro Cys Ser 
        595                 600                 605             


Ser Gly Leu Gly Asn Ser Asn Ser Ala Thr Pro His Leu Ser Pro Pro 
    610                 615                 620                 


Asp Trp Trp Lys Lys Ala Pro Ala Gly Pro Ser Leu Glu Glu Thr Ser 
625                 630                 635                 640 


Val Ser Ser Pro Lys Gly Ser Ser Glu Pro Cys Trp Leu Ile Arg Leu 
                645                 650                 655     


Cys Ile Ser Ile Val Val Leu Pro Lys Glu Asp Ser Cys Ser Gly Ser 
            660                 665                 670         


Asp Ala Gly Ser Ala Ala Gly Ser Thr Tyr Glu Pro Ser Pro Met Arg 
        675                 680                 685             


Leu Glu Ala Leu Gln Val Leu Thr Leu Leu Ala Arg Gly Tyr Phe Ser 
    690                 695                 700                 


Met Thr Gln Ala Tyr Leu Met Glu Leu Gly Glu Val Ile Cys Lys Cys 
705                 710                 715                 720 


Met Gly Glu Ala Asp Pro Ser Ile Gln Leu His Gly Ala Lys Leu Leu 
                725                 730                 735     


Glu Glu Leu Gly Thr Gly Leu Ile Gln Gln Tyr Lys Pro Asp Ser Thr 
            740                 745                 750         


Ala Ala Pro Asp Gln Arg Ala Pro Val Phe Leu Val Val Met Phe Trp 
        755                 760                 765             


Thr Met Met Leu Asn Gly Pro Leu Pro Arg Ala Leu Gln Asn Ser Glu 
    770                 775                 780                 


His Pro Thr Leu Gln Ala Ser Ala Cys Asp Ala Leu Ser Ser Ile Leu 
785                 790                 795                 800 


Pro Glu Ala Phe Ser Asn Leu Pro Asn Asp Arg Gln Met Leu Cys Ile 
                805                 810                 815     


Thr Val Leu Leu Gly Leu Asn Asp Ser Lys Asn Arg Leu Val Lys Ala 
            820                 825                 830         


Ala Thr Ser Arg Ala Leu Gly Val Tyr Val Leu Phe Pro Cys Leu Arg 
        835                 840                 845             


Gln Asp Val Ile Phe Val Ala Asp Ala Ala Asn Ala Ile Leu Met Ser 
    850                 855                 860                 


Leu Glu Asp Lys Ser Leu Asn Val Arg Ala Lys Ala Ala Trp Ser Leu 
865                 870                 875                 880 


Gly Asn Leu Thr Asp Thr Leu Ile Val Asn Met Glu Thr Pro Asp Pro 
                885                 890                 895     


Ser Phe Gln Glu Glu Phe Ser Gly Leu Leu Leu Leu Lys Met Leu Arg 
            900                 905                 910         


Ser Ala Ile Glu Ala Ser Lys Asp Lys Asp Lys Val Lys Ser Asn Ala 
        915                 920                 925             


Val Arg Ala Leu Gly Asn Leu Leu His Phe Leu Gln Pro Ser His Ile 
    930                 935                 940                 


Glu Lys Pro Thr Phe Ala Glu Ile Ile Glu Glu Ser Ile Gln Ala Leu 
945                 950                 955                 960 


Ile Ser Thr Val Leu Thr Glu Ala Ala Met Lys Val Arg Trp Asn Ala 
                965                 970                 975     


Cys Tyr Ala Met Gly Asn Val Phe Lys Asn Pro Ala Leu Pro Leu Gly 
            980                 985                 990         


Thr Ala Pro Trp Thr Ser Gln Ala  Tyr Asn Ala Leu Thr  Ser Val Val 
        995                 1000                 1005             


Thr Ser  Cys Lys Asn Phe Lys  Val Arg Ile Arg Ser  Ala Ala Ala 
    1010                 1015                 1020             


Leu Ser  Val Pro Gly Lys Arg  Glu Gln Tyr Gly Ser  Val Asp Gln 
    1025                 1030                 1035             


Tyr Ala  Arg Ile Trp Asn Ala  Leu Val Thr Ala Leu  Gln Lys Ser 
    1040                 1045                 1050             


Glu Asp  Thr Ile Asp Phe Leu  Glu Phe Lys Tyr Cys  Val Ser Leu 
    1055                 1060                 1065             


Arg Thr  Gln Ile Cys Gln Ala  Leu Ile His Leu Leu  Ser Leu Ala 
    1070                 1075                 1080             


Ser Ala  Ser Asp Leu Pro Cys  Met Lys Glu Thr Leu  Glu Leu Ser 
    1085                 1090                 1095             


Gly Asn  Met Val Gln Ser Tyr  Ile Leu Gln Phe Leu  Lys Ser Gly 
    1100                 1105                 1110             


Ala Glu  Gly Asp Asp Thr Gly  Ala Pro His Ser Pro  Gln Glu Arg 
    1115                 1120                 1125             


Asp Gln  Met Val Arg Met Ala  Leu Lys His Met Gly  Ser Ile Gln 
    1130                 1135                 1140             


Ala Pro  Thr Gly Asp Thr Ala  Arg Arg Ala Ile Met  Gly Phe Leu 
    1145                 1150                 1155             


Glu Glu  Ile Leu Ala Val Cys  Phe Asp Ser Ser Gly  Ser Gln Gly 
    1160                 1165                 1170             


Ala Leu  Pro Gly Leu Thr Asn  Gln 
    1175                 1180     


<210>  4923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEBP1__Homo_sapiens__NP_057071

<400>  4923

Met Leu Gly Met Ile Lys Asn Ser Leu Phe Gly Ser Val Glu Thr Trp 
1               5                   10                  15      


Pro Trp Gln Val Leu Ser Lys Gly Asp Lys Glu Glu Val Ala Tyr Glu 
            20                  25                  30          


Glu Arg Ala Cys Glu Gly Gly Lys Phe Ala Thr Val Glu Val Thr Asp 
        35                  40                  45              


Lys Pro Val Asp Glu Ala Leu Arg Glu Ala Met Pro Lys Val Ala Lys 
    50                  55                  60                  


Tyr Ala Gly Gly Thr Asn Asp Lys Gly Ile Gly Met Gly Met Thr Val 
65                  70                  75                  80  


Pro Ile Ser Phe Ala Val Phe Pro Asn Glu Asp Gly Ser Leu Gln Lys 
                85                  90                  95      


Lys Leu Lys Val Trp Phe Arg Ile Pro Asn Gln Phe Gln Ser Asp Pro 
            100                 105                 110         


Pro Ala Pro Ser Asp Lys Ser Val Lys Ile Glu Glu Arg Glu Gly Ile 
        115                 120                 125             


Thr Val Tyr Ser Met Gln Phe Gly Gly Tyr Ala Lys Glu Ala Asp Tyr 
    130                 135                 140                 


Val Ala Gln Ala Thr Arg Leu Arg Ala Ala Leu Glu Gly Thr Ala Thr 
145                 150                 155                 160 


Tyr Arg Gly Asp Ile Tyr Phe Cys Thr Gly Tyr Asp Pro Pro Met Lys 
                165                 170                 175     


Pro Tyr Gly Arg Arg Asn Glu Ile Trp Leu Leu Lys Thr 
            180                 185                 


<210>  4924
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEBP2__Homo_sapiens__NP_055135

<400>  4924

Met Ala Glu Pro Leu Gln Pro Asp Pro Gly Ala Ala Glu Asp Ala Ala 
1               5                   10                  15      


Ala Gln Ala Val Glu Thr Pro Gly Trp Lys Ala Pro Glu Asp Ala Gly 
            20                  25                  30          


Pro Gln Pro Gly Ser Tyr Glu Ile Arg His Tyr Gly Pro Ala Lys Trp 
        35                  40                  45              


Val Ser Thr Ser Val Glu Ser Met Asp Trp Asp Ser Ala Ile Gln Thr 
    50                  55                  60                  


Gly Phe Thr Lys Leu Asn Ser Tyr Ile Gln Gly Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Met Lys Ile Lys Met Thr Ala Pro Val Thr Ser Tyr Val Glu Pro Gly 
                85                  90                  95      


Ser Gly Pro Phe Ser Glu Ser Thr Ile Thr Ile Ser Leu Tyr Ile Pro 
            100                 105                 110         


Ser Glu Gln Gln Phe Asp Pro Pro Arg Pro Leu Glu Ser Asp Val Phe 
        115                 120                 125             


Ile Glu Asp Arg Ala Glu Met Thr Val Phe Val Arg Ser Phe Asp Gly 
    130                 135                 140                 


Phe Ser Ser Ala Gln Lys Asn Gln Glu Gln Leu Leu Thr Leu Ala Ser 
145                 150                 155                 160 


Ile Leu Arg Glu Asp Gly Lys Val Phe Asp Glu Lys Val Tyr Tyr Thr 
                165                 170                 175     


Ala Gly Tyr Asn Ser Pro Val Lys Leu Leu Asn Arg Asn Asn Glu Val 
            180                 185                 190         


Trp Leu Ile Gln Lys Asn Glu Pro Thr Lys Glu Asn Glu 
        195                 200                 205 


<210>  4925
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HECA__Homo_sapiens__NP_057301

<400>  4925

Met Pro Asn Pro Lys Asn Ser Lys Gly Gly Arg Lys Asn Lys Arg Ala 
1               5                   10                  15      


Asn Ser Ser Gly Asp Glu Gln Glu Asn Gly Ala Gly Ala Leu Ala Ala 
            20                  25                  30          


Ala Gly Ala Ala Gly Ala Ala Ala Gly Gly Ala Leu Ala Ala Ala Ala 
        35                  40                  45              


Gly Cys Gly Ala Ala Ala Ala Gly Ala Pro Gly Ala Gly Gly Ala Ala 
    50                  55                  60                  


Gly Ala Gly Gly Ala Gly Thr Gly Ala Ala Asn Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Ala Ala Ala Ala Gly Asp Ala Lys Asn Glu Ala Pro Cys Ala Thr 
                85                  90                  95      


Pro Leu Ile Cys Ser Phe Gly Arg Pro Val Asp Leu Glu Lys Asp Asp 
            100                 105                 110         


Tyr Gln Lys Val Val Cys Asn Asn Glu His Cys Pro Cys Ser Thr Trp 
        115                 120                 125             


Met His Leu Gln Cys Phe Tyr Glu Trp Glu Ser Ser Ile Leu Val Gln 
    130                 135                 140                 


Phe Asn Cys Ile Gly Arg Ala Arg Ser Trp Asn Glu Lys Gln Cys Arg 
145                 150                 155                 160 


Gln Asn Met Trp Thr Lys Lys Gly Tyr Asp Leu Ala Phe Arg Phe Cys 
                165                 170                 175     


Ser Cys Arg Cys Gly Gln Gly His Leu Lys Lys Asp Thr Asp Trp Tyr 
            180                 185                 190         


Gln Val Lys Arg Met Gln Asp Glu Lys Lys Lys Lys Ser Gly Ser Glu 
        195                 200                 205             


Lys Asn Thr Gly Arg Pro Pro Gly Glu Ala Ala Glu Glu Ala Lys Lys 
    210                 215                 220                 


Cys Arg Pro Pro Asn Lys Pro Gln Lys Gly Pro Ser His Asp Leu Pro 
225                 230                 235                 240 


Arg Arg His Ser Met Asp Arg Gln Asn Ser Gln Glu Lys Ala Val Gly 
                245                 250                 255     


Ala Ala Ala Tyr Gly Ala Arg Ser Pro Gly Gly Ser Pro Gly Gln Ser 
            260                 265                 270         


Pro Pro Thr Gly Tyr Ser Ile Leu Ser Pro Ala His Phe Ser Gly Pro 
        275                 280                 285             


Arg Ser Ser Arg Tyr Leu Gly Glu Phe Leu Lys Asn Ala Ile His Leu 
    290                 295                 300                 


Glu Pro His Lys Lys Ala Met Ala Gly Gly His Val Phe Arg Asn Ala 
305                 310                 315                 320 


His Phe Asp Tyr Ser Pro Ala Gly Leu Ala Val His Arg Gly Gly His 
                325                 330                 335     


Phe Asp Thr Pro Val Gln Phe Leu Arg Arg Leu Asp Leu Ser Glu Leu 
            340                 345                 350         


Leu Thr His Ile Pro Arg His Lys Leu Asn Thr Phe His Val Arg Met 
        355                 360                 365             


Glu Asp Asp Ala Gln Val Gly Gln Gly Glu Asp Leu Arg Lys Phe Ile 
    370                 375                 380                 


Leu Ala Ala Leu Ser Ala Ser His Arg Asn Val Val Asn Cys Ala Leu 
385                 390                 395                 400 


Cys His Arg Ala Leu Pro Val Phe Glu Gln Phe Pro Leu Val Asp Gly 
                405                 410                 415     


Thr Leu Phe Leu Ser Pro Ser Arg His Asp Glu Ile Glu Tyr Asp Val 
            420                 425                 430         


Pro Cys His Leu Gln Gly Arg Leu Met His Leu Tyr Ala Val Cys Val 
        435                 440                 445             


Asp Cys Leu Glu Gly Val His Lys Ile Ile Cys Ile Lys Cys Lys Ser 
    450                 455                 460                 


Arg Trp Asp Gly Ser Trp His Gln Leu Gly Thr Met Tyr Thr Tyr Asp 
465                 470                 475                 480 


Ile Leu Ala Ala Ser Pro Cys Cys Gln Ala Arg Leu Asn Cys Lys His 
                485                 490                 495     


Cys Gly Lys Pro Val Ile Asp Val Arg Ile Gly Met Gln Tyr Phe Ser 
            500                 505                 510         


Glu Tyr Ser Asn Val Gln Gln Cys Pro His Cys Gly Asn Leu Asp Tyr 
        515                 520                 525             


His Phe Val Lys Pro Phe Ser Ser Phe Lys Val Leu Glu Ala Tyr 
    530                 535                 540             


<210>  4926
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HECTD2__Homo_sapiens__NP_001271203

<400>  4926

Met Ser Glu Ala Val Arg Val Pro Ser Pro Ala Thr Pro Leu Val Val 
1               5                   10                  15      


Ala Ala Ala Ala Pro Glu Glu Arg Lys Gly Lys Glu Ser Glu Arg Glu 
            20                  25                  30          


Lys Leu Pro Pro Ile Val Ser Ala Gly Ala Gly Ala Thr Ala Gly Leu 
        35                  40                  45              


Asp Arg Gly Ala Lys Gly Gln Ile Ser Thr Phe Ser Ser Phe Ile Ser 
    50                  55                  60                  


Ala Val Ser Pro Lys Lys Glu Ala Ala Glu Asn Arg Ser Ser Pro Ala 
65                  70                  75                  80  


His Leu Val Phe Pro Asn Ile Lys Asn Val Arg Glu Pro Pro Pro Ile 
                85                  90                  95      


Cys Leu Asp Val Arg Gln Lys Gln Arg Thr Ser Met Asp Ala Ser Ser 
            100                 105                 110         


Ser Glu Met Lys Ala Pro Val Leu Pro Glu Pro Ile Leu Pro Ile Gln 
        115                 120                 125             


Pro Lys Thr Val Lys Asp Phe Gln Glu Asp Val Glu Lys Val Lys Ser 
    130                 135                 140                 


Ser Gly Asp Trp Lys Ala Val His Asp Phe Tyr Leu Thr Thr Phe Asp 
145                 150                 155                 160 


Ser Phe Pro Glu Leu Asn Ala Ala Phe Lys Lys Asp Ala Thr Ala Ser 
                165                 170                 175     


Phe Asn Thr Ile Glu Asp Ser Gly Ile Asn Ala Lys Phe Val Asn Ala 
            180                 185                 190         


Val Tyr Asp Thr Leu Leu Asn Thr Pro Gln Asp Val Gln Lys Thr Val 
        195                 200                 205             


Leu Lys Gly Ile Ile Asn Ser Leu Leu Arg Glu Trp Lys Gly Pro Arg 
    210                 215                 220                 


Thr Lys Asp Asp Leu Arg Ala Tyr Phe Ile Leu Leu Gln Asn Pro Gln 
225                 230                 235                 240 


Phe Asn Asn Thr Ser Thr Tyr Val Ile Tyr Ala His Leu Leu Arg Gln 
                245                 250                 255     


Ile Ala Thr Leu Val Glu Ala Asp His His Phe Leu Val His Trp Phe 
            260                 265                 270         


Lys Lys Gln Tyr Ser Arg Leu Ser Gln Lys Arg Phe Lys Gln Leu Val 
        275                 280                 285             


Glu Arg Leu Leu Gln Phe Ile Ser Leu Arg Leu Phe Pro Ala Lys Pro 
    290                 295                 300                 


Glu Glu Phe Pro Pro Ile Thr Lys Cys Ser Trp Trp Ile Pro Ser Ala 
305                 310                 315                 320 


Ala Lys Val Leu Ala Leu Leu Asn Thr Ala Asn Asn Leu Val His Pro 
                325                 330                 335     


Pro Leu Ile Pro Tyr Thr Asp Phe Tyr Asn Ser Thr Leu Asp His Ile 
            340                 345                 350         


Asp Leu Met Glu Glu Tyr His Thr Trp Gln Asn Phe Gly Asn Ser His 
        355                 360                 365             


Arg Phe Ser Phe Cys Gln Tyr Pro Phe Val Ile Ser Val Ala Ala Lys 
    370                 375                 380                 


Lys Ile Ile Ile Gln Arg Asp Ser Glu Gln Gln Met Ile Asn Ile Ala 
385                 390                 395                 400 


Arg Gln Ser Leu Val Asp Lys Val Ser Arg Arg Gln Arg Pro Asp Met 
                405                 410                 415     


Asn Ile Leu Phe Leu Asn Met Lys Val Arg Arg Thr His Leu Val Ser 
            420                 425                 430         


Asp Ser Leu Asp Glu Leu Thr Arg Lys Arg Ala Asp Leu Lys Lys Lys 
        435                 440                 445             


Leu Lys Val Thr Phe Val Gly Glu Ala Gly Leu Asp Met Gly Gly Leu 
    450                 455                 460                 


Thr Lys Glu Trp Phe Leu Leu Leu Ile Arg Gln Ile Phe His Pro Asp 
465                 470                 475                 480 


Tyr Gly Met Phe Thr Tyr His Lys Asp Ser His Cys His Trp Phe Ser 
                485                 490                 495     


Ser Phe Lys Cys Asp Asn Tyr Ser Glu Phe Arg Leu Val Gly Ile Leu 
            500                 505                 510         


Met Gly Leu Ala Val Tyr Asn Ser Ile Thr Leu Asp Ile Arg Phe Pro 
        515                 520                 525             


Pro Cys Cys Tyr Lys Lys Leu Leu Ser Pro Pro Ile Ile Pro Ser Asp 
    530                 535                 540                 


Gln Asn Ile Pro Val Gly Ile Cys Asn Val Thr Val Asp Asp Leu Cys 
545                 550                 555                 560 


Gln Ile Met Pro Glu Leu Ala His Gly Leu Ser Glu Leu Leu Ser His 
                565                 570                 575     


Glu Gly Asn Val Glu Glu Asp Phe Tyr Ser Thr Phe Gln Val Phe Gln 
            580                 585                 590         


Glu Glu Phe Gly Ile Ile Lys Ser Tyr Asn Leu Lys Pro Gly Gly Asp 
        595                 600                 605             


Lys Ile Ser Val Thr Asn Gln Asn Arg Lys Glu Tyr Val Gln Leu Tyr 
    610                 615                 620                 


Thr Asp Phe Leu Leu Asn Lys Ser Ile Tyr Lys Gln Phe Ala Ala Phe 
625                 630                 635                 640 


Tyr Tyr Gly Phe His Ser Val Cys Ala Ser Asn Ala Leu Met Leu Leu 
                645                 650                 655     


Arg Pro Glu Glu Val Glu Ile Leu Val Cys Gly Ser Pro Asp Leu Asp 
            660                 665                 670         


Met His Ala Leu Gln Arg Ser Thr Gln Tyr Asp Gly Tyr Ala Lys Thr 
        675                 680                 685             


Asp Leu Thr Ile Lys Tyr Phe Trp Asp Val Val Leu Gly Phe Pro Leu 
    690                 695                 700                 


Asp Leu Gln Lys Lys Leu Leu His Phe Thr Thr Gly Ser Asp Arg Val 
705                 710                 715                 720 


Pro Val Gly Gly Met Ala Asp Leu Asn Phe Lys Ile Ser Lys Asn Glu 
                725                 730                 735     


Thr Ser Thr Asn Cys Leu Pro Val Ala His Thr Cys Phe Asn Gln Leu 
            740                 745                 750         


Cys Leu Pro Pro Tyr Lys Ser Lys Lys Asp Leu Lys Gln Lys Leu Ile 
        755                 760                 765             


Ile Gly Ile Ser Asn Ser Glu Gly Phe Gly Leu Glu 
    770                 775                 780 


<210>  4927
<211>  4284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HECTD4__Homo_sapiens__NP_001103132

<400>  4927

Met Gly Leu Leu Leu Val Phe Pro Leu Ile Gln Ser Gln Ser Arg Thr 
1               5                   10                  15      


Asp Pro Ser Leu Cys Asn Ile Thr Ala Glu Val Leu Leu Asn Cys Leu 
            20                  25                  30          


Arg Asp Cys Gln Pro Leu Ser Leu Thr Lys Glu Pro Ala Asp Cys Leu 
        35                  40                  45              


Asn Gly Ile Glu Thr Leu Leu Cys Ser Trp Leu Glu Glu Thr Ser Asp 
    50                  55                  60                  


Thr Gly Arg His Ile Pro His Lys Gln Lys Glu Asn Ala Ala Ala Ala 
65                  70                  75                  80  


Leu Val Ala Leu Ala Cys Ala Arg Gly Ser Leu Lys Thr Phe Val His 
                85                  90                  95      


Thr Val His Leu Leu Gln Lys Gln Thr Asp Leu Gly Ser Leu Pro Val 
            100                 105                 110         


Ala Asp Val Leu Tyr Arg Leu Leu Leu Leu Glu Gly Gly Pro Gly Ser 
        115                 120                 125             


Pro Ser Cys Leu Leu Gly Gly Lys His Ile Val Ser Trp Gly Tyr Glu 
    130                 135                 140                 


Asp Met Leu Pro Ala Pro Asp Ser Asn Thr Gly Ser Ser Ser Glu Asn 
145                 150                 155                 160 


Lys Asp Ala Asp Leu Gly Arg Cys Leu Thr Ala Asp Gly Leu Tyr Leu 
                165                 170                 175     


Tyr Thr Thr Asn Ser Val Gly Arg Gly Val Ser Lys Leu Gly Ser Gly 
            180                 185                 190         


Leu His Gly Thr Leu Arg Gly Phe Val Tyr Cys Arg Asn Glu Glu Leu 
        195                 200                 205             


Glu Pro Gly Trp Val Ala Phe Gly Ser Gly Ser Leu Leu His Arg Pro 
    210                 215                 220                 


Val Ser Phe Asp Asn Lys Pro His Ser Leu Phe Gln Val Ile Asp Gln 
225                 230                 235                 240 


Asn Thr Leu Gln Val Cys Gln Val Val Pro Met Pro Ala Asn His Leu 
                245                 250                 255     


Pro Ile Gly Ser Thr Met Ser Thr Val His Leu Ser Ser Asp Gly Thr 
            260                 265                 270         


Tyr Phe Tyr Trp Ile Trp Ser Pro Ala Ser Leu Asn Glu Lys Thr Pro 
        275                 280                 285             


Lys Gly His Ser Val Phe Met Asp Ile Phe Glu Leu Val Val Glu Asn 
    290                 295                 300                 


Gly Val Phe Val Ala Asn Pro Leu Gln Glu Arg Thr Ile Leu Met Arg 
305                 310                 315                 320 


Lys Glu Gly Glu Ser Ala Lys Ser Ile Asn Glu Met Leu Leu Ser Arg 
                325                 330                 335     


Leu Ser Arg Tyr Arg Ala Ser Pro Ser Ala Thr Leu Ala Ala Leu Thr 
            340                 345                 350         


Gly Ser Thr Ile Ser Asn Thr Leu Lys Glu Asp Gln Ala Ala Asn Thr 
        355                 360                 365             


Ser Cys Gly Leu Pro Leu Lys Met Leu Arg Lys Thr Pro Ile Tyr Thr 
    370                 375                 380                 


Cys Gly Thr Tyr Leu Val Met Leu Val Pro Pro Pro Gly Gly Ser Gly 
385                 390                 395                 400 


Ser Ser Ala Thr Arg Ser Leu Phe Gly Gly Thr Ser Gly Leu Ser Ser 
                405                 410                 415     


Leu Lys Ile Leu Ala Ser Ser Leu Val Tyr Asn Ile Ser Asp Gly Gln 
            420                 425                 430         


Phe Thr Ser Arg Ala Asp Leu Ile Asp Ala Ala Gly Ser Ser Leu Gly 
        435                 440                 445             


Arg Gly Ala Leu Val Pro Gly Leu Gly Ala Cys Tyr Asp Thr Val Asn 
    450                 455                 460                 


Asn Met Leu Trp Thr Cys Ser Asn Asp Tyr Ile Asp Gln Trp Cys Asn 
465                 470                 475                 480 


Pro Gly Asn Gln Ala Phe His Tyr Val Cys Gln Arg Leu Gly Val Ser 
                485                 490                 495     


His Ile Ile Thr Glu Pro Lys Glu Glu Ala Ile Thr Thr Asn Glu Val 
            500                 505                 510         


Ile Asn Gln Leu Leu His His Val Gly Ala Met Cys Ile His Gln Leu 
        515                 520                 525             


Asn Leu Leu Ala Thr Asn Pro Asn Leu Pro Ile Thr Ser Val Leu Gly 
    530                 535                 540                 


Lys Gln His Pro Ile Glu Ala His His Leu Ser Ser Ile Cys Asp Ile 
545                 550                 555                 560 


Met Glu Lys Ala Met Val Asn Gly Asp Thr Cys Ile Ile Arg Cys Ile 
                565                 570                 575     


Leu Val Val Phe Gln Val Val Phe Lys Phe Phe Phe Ser Pro Gln Thr 
            580                 585                 590         


Glu Arg Asn Arg Asp Ile Ile Arg Arg Ser Gly Leu Leu Leu Trp Gln 
        595                 600                 605             


Leu Leu Met Ala Pro Lys Asp Gln Ile Cys Pro Glu Ile Gln Lys Glu 
    610                 615                 620                 


Val Cys Leu Ala Ile Ser Ser Gly Leu Asn Ile Leu Tyr Pro Gly Glu 
625                 630                 635                 640 


Thr Glu Ile Asn Asn Leu Leu Lys Leu Val Leu Thr Glu Gly Glu Arg 
                645                 650                 655     


Asn Ser Gly Leu Ser Gln Leu Arg Asp Val Ile Leu Thr Asn Leu Ala 
            660                 665                 670         


Glu Gln Leu Gln Asn Asn Arg Phe Gly Ser Asp Glu Asp Asp His Tyr 
        675                 680                 685             


Arg Leu Asn Asp Glu Leu Leu His Tyr Ile Leu Lys Ile Val Val Arg 
    690                 695                 700                 


Glu Ser Cys Ile Leu Ile Thr Lys Cys Gln Thr Val Ser Lys Asp Asp 
705                 710                 715                 720 


Phe Gln Lys Leu Leu Ser Thr Val Pro Ala Ala Ser Ser Cys Leu Arg 
                725                 730                 735     


Tyr Leu Met Ala Val Gln Asn His Leu Leu Ser Asn Thr Ile Leu Ile 
            740                 745                 750         


Lys Pro Asp Glu Asn Asp Asp Ser Asp Ser Ser Leu Gln Gly Glu Thr 
        755                 760                 765             


Leu Lys Val Gln Glu Leu Lys Val Ser Ile Leu Ala Leu Ala Thr Gln 
    770                 775                 780                 


Ile Leu Thr Gly Cys Asp Glu Val Leu Glu Met Leu Gln Gln Val Thr 
785                 790                 795                 800 


Thr Ala Leu Ile Asn Ser Asp Ile Ala Asp Arg Glu Gln Arg Leu Lys 
                805                 810                 815     


Gly Leu Glu Gln Val Thr Lys Ala Thr Met Leu Gly His Leu Leu Pro 
            820                 825                 830         


Val Leu Leu Thr Ser Leu Met His Pro Asn Leu Gln Thr Leu Ile Met 
        835                 840                 845             


Ala Asp Ala Leu Met Pro Gln Leu Val Gln Leu Val Leu Tyr Thr Ser 
    850                 855                 860                 


Gln Thr Ala Leu Leu Leu Lys Thr Gln Cys Pro Val Phe Ala Glu Val 
865                 870                 875                 880 


Gly Cys Ser Pro Cys Gly Ala Pro Asp Gln Lys Cys Arg Leu Phe Pro 
                885                 890                 895     


Asp Glu Arg Met Leu Glu Glu Lys Glu Glu Pro Gly Phe Leu Thr Gly 
            900                 905                 910         


Leu Lys Ile Pro Ala Pro Trp Ala Ala Gly Lys Thr Val Glu Thr Val 
        915                 920                 925             


His Pro Val Arg Asp Asn Tyr Lys Phe Lys Glu Thr Val His Ile Pro 
    930                 935                 940                 


Gly Ala Arg Cys Leu Tyr Leu Arg Phe Asp Ser Arg Cys Ser Ser Gln 
945                 950                 955                 960 


Tyr Asp Tyr Asp Lys Leu Val Ile Tyr Ala Gly Pro Asn Thr Asn Ser 
                965                 970                 975     


Arg Lys Val Ala Glu Tyr Gly Gly Asn Thr Leu Gly Tyr Gly Ser Arg 
            980                 985                 990         


Ser Val Leu Gly Thr Gly Trp Pro  Lys Asp Leu Val Lys  Cys Ile Ser 
        995                 1000                 1005             


Pro Pro  Ser Leu Asn Phe Lys  Val Glu Gly Asp Thr  Val Thr Phe 
    1010                 1015                 1020             


Ser Phe  Glu Met Arg Ser Gly  Arg Glu His Asn Thr  Pro Asp Lys 
    1025                 1030                 1035             


Ala Met  Trp Gly Phe Ala Cys  Thr Val Arg Ala Gln  Glu Ser Ser 
    1040                 1045                 1050             


Glu Asp  Val Ser Gly Gly Leu  Pro Phe Leu Val Asp  Leu Ala Leu 
    1055                 1060                 1065             


Gly Leu  Ser Val Leu Ala Cys  Ser Met Leu Arg Ile  Leu Tyr Asn 
    1070                 1075                 1080             


Gly Pro  Glu Ile Thr Lys Glu  Glu Glu Ala Cys Gln  Glu Leu Leu 
    1085                 1090                 1095             


Arg Ser  Lys Leu Leu Gln Arg  Cys Gln Trp Gln Val  Glu Ala Asn 
    1100                 1105                 1110             


Gly Val  Ile Ser Pro Ala Leu  Thr Pro Ser Pro Ser  Pro Leu Pro 
    1115                 1120                 1125             


Leu Thr  Ile Glu Glu Asp Arg  Glu Phe Thr Tyr Pro  Ser Asp Val 
    1130                 1135                 1140             


Leu Val  Pro Pro Val Gly Asn  Tyr Phe Asp Leu Pro  Arg Ile Arg 
    1145                 1150                 1155             


Leu Pro  Pro Gly Ile Met Ile  Lys Leu Arg Glu Ile  Ser Gly Arg 
    1160                 1165                 1170             


Ala Arg  Pro Gln Phe Arg Pro  Ser Ile Lys Glu Val  Ile Gln Pro 
    1175                 1180                 1185             


Asp Val  Met Glu Glu Met Val  Val Ser Cys Val Ile  Lys His Leu 
    1190                 1195                 1200             


Asn Leu  Val Asp Ala Leu Gln  Ser Leu Ile Asn Phe  Gln Tyr Gln 
    1205                 1210                 1215             


Glu Glu  His Ala Glu Glu Tyr  Asp Leu Leu Cys Lys  Ile Met Gly 
    1220                 1225                 1230             


Glu Thr  Phe Lys Lys Leu Asn  Ala Met Glu Arg Gln  Leu Gln Ser 
    1235                 1240                 1245             


Val Ala  Glu Leu Glu Gln Lys  Trp Gln Ser Glu Val  Asp Asp Ala 
    1250                 1255                 1260             


Met Gln  Gly Lys Leu Glu Asn  Asn Met Pro Phe Phe  Tyr Asp Tyr 
    1265                 1270                 1275             


His Phe  Asn Glu Asn Lys Met  Lys Glu Leu Glu Leu  Leu Cys Ser 
    1280                 1285                 1290             


Met Lys  Glu Val Ser Phe Asp  Gly Asn Asp Leu Glu  Asn Met Val 
    1295                 1300                 1305             


Leu Ser  Leu Arg Glu Lys Phe  Leu Gln Glu Val Asn  Ser Leu Ile 
    1310                 1315                 1320             


Gln Lys  Pro Ser His Pro Leu  Ala Lys Thr Lys Thr  Leu Val Lys 
    1325                 1330                 1335             


Ser Leu  Met Asn Arg Ala Glu  Leu Leu Leu His Val  Thr Ile Ala 
    1340                 1345                 1350             


Ala Gln  Ser Gly Leu Thr Arg  Ser Ile Ser Gly Thr  Pro Ala Glu 
    1355                 1360                 1365             


Thr Pro  Ala Cys Lys Ser Ala  Ser Glu Thr Lys Val  Ile Ser His 
    1370                 1375                 1380             


Ala Val  Arg Gln Pro Val Phe  Leu Arg Ser Met Ser  Ala Pro Ser 
    1385                 1390                 1395             


Asp Leu  Glu Met Ile Gly Asn  Glu Asp Leu Glu Phe  Thr Arg Ala 
    1400                 1405                 1410             


Asn Gln  Arg Arg Arg His Val  Thr Ser His Arg Ser  Ser Ser Phe 
    1415                 1420                 1425             


Thr Leu  Leu Gln Ser Leu Ala  Ile Glu Asp Ser Arg  Asp Lys Pro 
    1430                 1435                 1440             


Thr Tyr  Ser Val Leu Leu Gly  Gln Leu Phe Ala Phe  Ile Gly Thr 
    1445                 1450                 1455             


Asn Pro  Asp Gln Ala Val Ser  Ser Ser Ser Phe Leu  Leu Ala Ala 
    1460                 1465                 1470             


Gln Thr  Arg Trp Arg Arg Gly  Asn Thr Arg Lys Gln  Ala Leu Val 
    1475                 1480                 1485             


His Met  Arg Glu Leu Leu Thr  Ala Ala Val Arg Val  Gly Gly Val 
    1490                 1495                 1500             


Thr His  Leu Val Gly Pro Val  Thr Met Val Leu Gln  Gly Gly Pro 
    1505                 1510                 1515             


Arg Ile  Glu Glu Leu Thr Cys  Gly Gly Met Val Glu  Gln Val Gln 
    1520                 1525                 1530             


Glu Ala  Phe Gly Glu Thr Met  Thr Ser Val Val Ser  Leu Cys Ala 
    1535                 1540                 1545             


Arg Tyr  Pro Ile Ala Cys Ala  Asn Ser Ile Gly Leu  Leu Cys Thr 
    1550                 1555                 1560             


Ile Pro  Tyr Thr Arg Ser Glu  Glu Lys Cys Leu Val  Arg Ser Gly 
    1565                 1570                 1575             


Leu Val  Gln Leu Met Asp Arg  Leu Cys Ser Leu Ser  Asn Gln Thr 
    1580                 1585                 1590             


Glu Ser  Ser Ser Ser Glu Lys  Gln Thr Lys Lys Gln  Lys Val Ala 
    1595                 1600                 1605             


Thr Met  Ala Trp Ala Ala Phe  Gln Val Leu Ala Asn  Arg Cys Val 
    1610                 1615                 1620             


Glu Trp  Glu Lys Glu Glu Gly  Gly Ser Thr Glu Ala  Val His Ser 
    1625                 1630                 1635             


Gly Leu  Ala Arg Gln Val Ser  Ser Leu Leu Thr Asn  His Leu Ala 
    1640                 1645                 1650             


Arg Ala  Thr Glu Cys Cys Gly  Asn Gln Ala Ala Gly  Asn Asp Ala 
    1655                 1660                 1665             


Leu Gln  Asp Val Leu Ser Leu  Leu Asn Asp Leu Ser  Arg Ser His 
    1670                 1675                 1680             


Ile Gly  Lys Ala Ile Leu Ser  Gln Pro Ala Cys Val  Ser Lys Leu 
    1685                 1690                 1695             


Leu Ser  Leu Leu Leu Asp Gln  Arg Pro Ser Pro Lys  Leu Val Leu 
    1700                 1705                 1710             


Ile Ile  Leu Gln Leu Cys Arg  Ala Ala Leu Pro Leu  Met Ser Val 
    1715                 1720                 1725             


Glu Asp  Cys Gly Asn Val Glu  Leu Pro Pro Trp Ser  Tyr Ser Val 
    1730                 1735                 1740             


Pro Ser  Leu Asn Ser Glu Gln  Glu Asp Pro Ser Asp  Pro Ala Ser 
    1745                 1750                 1755             


Lys Ile  Ala Ser Leu Leu Leu  Ala Lys Leu Ala Asp  Tyr Val Val 
    1760                 1765                 1770             


Pro Gly  Cys Gln Thr Val Leu  Ser Pro Thr Ala Ser  Glu Pro Asp 
    1775                 1780                 1785             


Thr Thr  Leu Thr Lys Thr Ser  Pro Lys Asn Ser Leu  Lys Gly Asp 
    1790                 1795                 1800             


Lys Asp  Pro Gly Glu Glu Ser  Glu Ala Val Asp Gly  Lys Leu Ser 
    1805                 1810                 1815             


Ile Phe  Ile His Lys Arg Glu  Asp Gln Ser Ser His  Glu Val Leu 
    1820                 1825                 1830             


Gln Pro  Leu Leu Ser Ser Ser  Glu Gly Arg Pro Phe  Arg Leu Gly 
    1835                 1840                 1845             


Thr Gly  Ala Asn Met Glu Lys  Val Val Lys Met Asp  Arg Asp Met 
    1850                 1855                 1860             


Thr Lys  Gly Gly Cys Cys Glu  Val Ile Thr Glu Glu  Ala Ala Ala 
    1865                 1870                 1875             


Ala Leu  Arg Lys Ala Thr Lys  Trp Ala Gln Ser Gly  Leu Ile Val 
    1880                 1885                 1890             


Ser Ile  Gly Pro Pro Val Glu  Ser Ile Asn Pro Glu  Thr Val Ser 
    1895                 1900                 1905             


Gly Leu  Ser Thr Gly Asp Lys  Lys Lys Thr Ala Gln  Thr Ser Ile 
    1910                 1915                 1920             


Cys Arg  Glu Arg Asn Ser Glu  Leu Ala Arg Thr Asp  Pro Val Arg 
    1925                 1930                 1935             


Pro Phe  Ile Ser Gly His Val  Ala Asn Ser Met Ala  Ala Glu Val 
    1940                 1945                 1950             


Ile Ala  Leu Leu His Ser Leu  Leu Met Ala Pro Glu  Ser Asn Ala 
    1955                 1960                 1965             


Ala Gln  Ile Trp Thr Thr Thr  Ala Glu Lys Val Leu  Ser Arg Ala 
    1970                 1975                 1980             


Leu Met  Tyr Ile Pro Gln Leu  Gly Lys Tyr Ala Glu  Ser Ile Leu 
    1985                 1990                 1995             


Glu Asn  Gly Ser Ser Ser Gly  Arg Lys Leu Ala Lys  Leu Gln Arg 
    2000                 2005                 2010             


Ile Ala  Arg Gln Ala Val Ala  Ala Leu Cys Ala Leu  Gly Gly Phe 
    2015                 2020                 2025             


Lys Glu  Thr Ile Lys Ile Gly  Ser Glu Val Gln Val  Leu Gly Arg 
    2030                 2035                 2040             


Gly Ile  Ser Gly Ser Ile Gly  Val Val Ala Ser Ile  Asn Glu Gln 
    2045                 2050                 2055             


Glu Gly  Ile Ala Thr Val Arg  Phe Pro Pro Ile Asp  Cys Arg Lys 
    2060                 2065                 2070             


Thr Ser  Gln Ala Ser Asp Thr  Leu Thr Ile Pro Leu  Ser Arg Leu 
    2075                 2080                 2085             


Cys Val  Pro Arg Ser Glu Ala  Leu Pro Leu His Lys  Leu Ser Ile 
    2090                 2095                 2100             


Thr Glu  Lys Val Val Gln Ala  Val Gln Ser Met Leu  Leu Pro Gln 
    2105                 2110                 2115             


Glu Gly  Ser Leu Ser Ile His  Thr Ser Leu Pro Ala  Thr Gly Asp 
    2120                 2125                 2130             


Gly Ser  Ala Pro Val Met Ala  Val Val Arg Leu Leu  Ala Glu Ile 
    2135                 2140                 2145             


Arg Thr  Arg Ala Cys Leu Val  Met Ala Gln Leu Leu  Glu Asp Ser 
    2150                 2155                 2160             


Leu Phe  Cys Glu Glu Phe Ile  Gln Gln Cys Pro Ala  Ala Val Glu 
    2165                 2170                 2175             


Val Leu  Asn Leu Val Ala Gln  Glu Cys Ser Ala Gly  Glu Arg Leu 
    2180                 2185                 2190             


Ala Val  Val Glu Val Gln Cys  Glu Arg Leu Arg Met  Leu Tyr Arg 
    2195                 2200                 2205             


Asp Cys  Ala Arg Pro Pro Pro  Pro Pro Leu Gln Ala  Asp Arg Arg 
    2210                 2215                 2220             


Gln Pro  Lys Glu Ile Thr Trp  Ser Pro Ser Arg Val  Phe Pro Pro 
    2225                 2230                 2235             


Val Arg  Ala Cys Met Phe Ser  Ser His Leu Thr Ser  Val Thr Phe 
    2240                 2245                 2250             


Leu Ala  Asp Pro Ser Ala Gly  Gly Gly Leu Pro Arg  Gly Thr Phe 
    2255                 2260                 2265             


Ile Tyr  Ala Thr Ser Pro Leu  Pro Val Gln Ala Pro  Ser Phe Tyr 
    2270                 2275                 2280             


Trp Glu  Ile Glu Ile Val Ser  Tyr Gly Asp Thr Asp  Asp Asp Thr 
    2285                 2290                 2295             


Gly Pro  Ile Val Ser Phe Gly  Phe Thr Thr Glu Ala  Glu Lys Arg 
    2300                 2305                 2310             


Asp Gly  Ala Trp Thr Asn Pro  Val Gly Thr Cys Leu  Phe His Asn 
    2315                 2320                 2325             


Asn Gly  Arg Ala Val His Tyr  Asn Gly Ser Ser Leu  Leu Gln Trp 
    2330                 2335                 2340             


Lys Ser  Val Arg Leu Asp Val  Thr Leu Ser Pro Gly  Asp Val Ala 
    2345                 2350                 2355             


Gly Ile  Gly Trp Glu Arg Thr  Glu Gly Thr Pro Pro  Pro Pro Gly 
    2360                 2365                 2370             


Gln Pro  Ala Lys Gly Arg Val  Tyr Phe Thr Tyr Cys  Gly Gln Arg 
    2375                 2380                 2385             


Leu Ser  Pro Tyr Leu Glu Asp  Val Ser Gly Gly Met  Trp Pro Val 
    2390                 2395                 2400             


Val His  Ile Gln Lys Lys Asn  Thr Lys Thr Arg Ala  Asn Phe Gly 
    2405                 2410                 2415             


Ser Arg  Pro Phe Ala Tyr Ala  Glu Gly Gln Ala His  Arg Asn Ala 
    2420                 2425                 2430             


Ala Asp  Leu Cys Thr Asp Leu  Ala Glu Glu Ile Ser  Ala Asn Phe 
    2435                 2440                 2445             


Glu Ala  Leu Pro Phe Ala Met  Ala Ser Asp Ser Asp  Asn Asp Ala 
    2450                 2455                 2460             


Gly Thr  Ser Ile Ala Ser Asp  Pro Gly Thr His Gly  Pro Pro Cys 
    2465                 2470                 2475             


Arg Ile  Ala Ala Val Ala Thr  Ala Gln Gln Gln Tyr  Asp Ser Asp 
    2480                 2485                 2490             


Thr Ser  Cys His Tyr Lys Val  Glu Leu Ser Tyr Glu  Asn Phe Ile 
    2495                 2500                 2505             


Thr Ser  Gly Pro Asp Pro His  Pro Pro Pro Ile Ala  Asp Asp Glu 
    2510                 2515                 2520             


Ser Asp  Asp Asp Asp Asp Asp  Asp Ile Pro Gln Glu  Asp His Tyr 
    2525                 2530                 2535             


Ala Leu  Leu Val Lys Ala Trp  Glu Thr Lys Val Phe  Pro Thr Ile 
    2540                 2545                 2550             


Arg Arg  Arg Phe Arg Asn Glu  Ala Glu Arg Lys Ser  Gly Leu Asp 
    2555                 2560                 2565             


Gln Ile  Lys Gly Ala Leu Gln  Leu Gly Met Val Asp  Ile Ala Arg 
    2570                 2575                 2580             


Gln Thr  Val Glu Phe Leu Tyr  Glu Glu Asn Gly Gly  Ile Pro Arg 
    2585                 2590                 2595             


Asp Leu  Tyr Leu Pro Thr Ile  Glu Asp Ile Lys Asp  Glu Ala Asn 
    2600                 2605                 2610             


Lys Phe  Thr Ile Asp Lys Val  Arg Lys Gly Leu Thr  Val Val Thr 
    2615                 2620                 2625             


Arg Ser  Pro Asp Ser Asn Asn  Val Ala Ser Ser Ala  Val Gly Thr 
    2630                 2635                 2640             


Ala Leu  Pro Lys Phe Ala Ile  Arg Gly Met Leu Lys  Thr Phe Gly 
    2645                 2650                 2655             


Leu His  Gly Val Val Leu Asp  Val Asp Ser Val Asn  Glu Leu Val 
    2660                 2665                 2670             


Gln Val  Glu Thr Tyr Leu Arg  Ser Glu Gly Val Leu  Val Arg Tyr 
    2675                 2680                 2685             


Trp Tyr  Pro Ile Asp Met Leu  Glu Arg Pro Pro Ala  Gly Tyr Arg 
    2690                 2695                 2700             


Arg Thr  Ala Thr Asn Gly Leu  Val Thr Leu Asp Asn  Thr Asn Leu 
    2705                 2710                 2715             


Gln Ile  His Arg Glu Leu Leu  Arg Cys Glu Ala Ala  Leu Ala Arg 
    2720                 2725                 2730             


Leu Tyr  Cys Arg Met Ala Leu  Leu Asn Ile Phe Ala  Pro Lys Leu 
    2735                 2740                 2745             


Pro His  Leu Phe Thr Arg Leu  Phe His Ile Pro Ala  Ile Arg Asp 
    2750                 2755                 2760             


Ile Thr  Leu Glu His Leu Gln  Leu Leu Ser Asn Gln  Leu Leu Ala 
    2765                 2770                 2775             


Pro Pro  Leu Pro Asp Gly Thr  Ile Ser Ser Ser Ser  Ile Leu Leu 
    2780                 2785                 2790             


Ala Gln  Ser Leu Gln His Cys  Ile His Ser Gln Asn  Cys Ser Ala 
    2795                 2800                 2805             


Thr Asp  Leu Phe Tyr Gln Gly  Asn Ser Gln Thr Val  Arg Glu Trp 
    2810                 2815                 2820             


Leu Asn  Val Ala Ile Thr Arg  Thr Leu His Gln Gly  Glu Glu Ser 
    2825                 2830                 2835             


Leu Leu  Glu Leu Thr Lys Gln  Ile Cys Ser Phe Leu  Gln Thr Ala 
    2840                 2845                 2850             


Pro Glu  Gln Phe Pro Ser Glu  Glu Phe Pro Ile Ser  Glu Ser Lys 
    2855                 2860                 2865             


Val Asn  Met Asp Val Asn Phe  Pro Gly Ala Ala Phe  Val Val Val 
    2870                 2875                 2880             


Ser Cys  Lys Glu Ser Gln Ser  Gly Phe Arg Lys Asp  Ser Ser Leu 
    2885                 2890                 2895             


Tyr Lys  Ala Pro Trp Ala Arg  Val Leu Val Tyr Gly  Leu Gly His 
    2900                 2905                 2910             


Lys Val  Lys Arg Asn Gly Gln  Leu Asn Leu Ile Glu  Ala Ala Cys 
    2915                 2920                 2925             


Tyr Pro  Arg Asp Ala Ser Pro  Ala Asn Thr Gly Leu  Ala Pro Pro 
    2930                 2935                 2940             


Pro Thr  Ala Asp Gln Tyr Pro  Ser Val Val Leu Ser  Thr Asp Arg 
    2945                 2950                 2955             


Val His  Ile Lys Leu Gly Val  Ser Pro Pro Pro Gly  Ala Val Leu 
    2960                 2965                 2970             


Val Leu  His Ser Leu Pro Leu  Glu Phe Pro Leu Ala  Met Ala Phe 
    2975                 2980                 2985             


Ala Glu  Gln Leu Leu Ser Trp  Lys Ser Glu Asp Ser  Glu Gly Lys 
    2990                 2995                 3000             


Ser Glu  Asp Glu Pro Asp Thr  Ile Pro Thr Ser Val  Leu Leu Gln 
    3005                 3010                 3015             


Val Val  Glu Leu Leu Gly Asn  Phe Leu Trp Thr Thr  Asp Met Ala 
    3020                 3025                 3030             


Ala Cys  Val Lys Glu Leu Val  Phe His Leu Leu Ala  Glu Leu Leu 
    3035                 3040                 3045             


Arg Thr  Val His Thr Leu Glu  Gln Arg Arg His Pro  Ala Gly Leu 
    3050                 3055                 3060             


Ser Ser  Ser Ile Ala Leu Gln  Leu Asn Pro Cys Leu  Ala Met Leu 
    3065                 3070                 3075             


Met Ala  Leu Gln Ser Glu Leu  His Lys Leu Tyr Asp  Glu Glu Thr 
    3080                 3085                 3090             


Gln Asn  Trp Val Ser Gly Gly  Ala Cys Gly Gly Ser  Gly Gly Ala 
    3095                 3100                 3105             


Ala Ala  Gly Asp Gln Gly Arg  Phe Ser Thr Tyr Phe  His Ala Leu 
    3110                 3115                 3120             


Met Glu  Gly Cys Leu Ala Val  Ala Glu Val Thr Leu  Pro Thr Asn 
    3125                 3130                 3135             


Met Ser  Val Thr Ala Ser Gly  Val Thr Ser Ala Thr  Ala Pro Asn 
    3140                 3145                 3150             


Leu Ser  Asp Ser Ser Ser Ser  Ser Ser Ser Ser Pro  Gly Gln Thr 
    3155                 3160                 3165             


Pro Gln  Ser Pro Ser Leu Leu  Ser Lys Arg Lys Lys  Val Lys Met 
    3170                 3175                 3180             


Lys Arg  Glu Lys Ala Ser Ser  Ser Gly Lys Arg Gln  Ser Ser Arg 
    3185                 3190                 3195             


Thr Val  Asp Ser Asp Pro Thr  Val Leu Ser Ile Gly  Gly Ser Lys 
    3200                 3205                 3210             


Pro Glu  Asp Met Leu Trp Phe  His Arg Ala Leu Thr  Leu Leu Ile 
    3215                 3220                 3225             


Ile Leu  Arg His Leu Thr Arg  Lys Asp Pro Gln Gly  Leu Gly Val 
    3230                 3235                 3240             


Thr Ser  Asp Ala Ile Ala Asp  Ala Cys Gln Ala Leu  Val Gly Pro 
    3245                 3250                 3255             


Thr Ala  His Ser Arg Leu Leu  Val Ile Ser Gly Ile  Pro Thr His 
    3260                 3265                 3270             


Leu Asp  Glu Gly Val Val Arg  Gly Ala Ile Arg Lys  Ala Cys Asn 
    3275                 3280                 3285             


Ala His  Gly Gly Val Phe Lys  Asp Glu Ile Tyr Ile  Pro Leu Gln 
    3290                 3295                 3300             


Glu Glu  Asp Thr Lys Lys Pro  Lys Asp Lys Ala Glu  Gly Gly Asp 
    3305                 3310                 3315             


Gly Lys  Val Glu Pro Glu Lys  Thr Leu Ala Phe Pro  Gly Thr Asp 
    3320                 3325                 3330             


Ser Met  Glu Val Ser Thr Ser  Ser Ser Leu Thr Pro  Ala Met Ser 
    3335                 3340                 3345             


Ile Ser  Ala Ser Ala Ser Thr  Ser Gln Ala Ser Ile  Cys Ser Ser 
    3350                 3355                 3360             


Gln Gly  Ile Ser Gln Thr Val  Ser Asp Leu Ser Val  Asp Pro Leu 
    3365                 3370                 3375             


Pro Ala  Gly Leu Glu Leu Pro  Ile Pro Pro Gly Leu  Leu Glu Pro 
    3380                 3385                 3390             


His Ala  Val Ser Ser Gln Glu  Ser Leu Asp Ile Ser  Leu Cys Ser 
    3395                 3400                 3405             


Thr Gly  Ser Leu Gly Ser Leu  Gly Ser Leu Gly Glu  Pro Leu Asp 
    3410                 3415                 3420             


Asn Ala  Glu Thr Ala Ser Val  Ser Asp Met Gly Ser  Met Tyr Thr 
    3425                 3430                 3435             


Val Thr  Ser Leu Asp Asn Gln  Pro Leu Ala Ala Arg  Pro Ile Lys 
    3440                 3445                 3450             


Gly Phe  Ala Val Val Glu Ile  Arg Ser Arg Ala Lys  Ile Glu Lys 
    3455                 3460                 3465             


Ile Arg  Ala Ser Leu Phe Asn  Asn Asn Asp Leu Ile  Gly Leu Ser 
    3470                 3475                 3480             


Ser Leu  Asp Gly Glu Asp Glu  Leu Met Glu Met Ser  Thr Glu Glu 
    3485                 3490                 3495             


Ile Leu  Thr Val Ser Val Val  Asn Gln Ser Leu Phe  Asp Thr Gln 
    3500                 3505                 3510             


Gly Ser  Pro Gly Leu Glu Asp  Tyr Phe Asn Asp Lys  Ser Ile Lys 
    3515                 3520                 3525             


Gly Glu  Lys Leu Val Pro Gly  Ala Arg Glu Val Leu  Thr Glu Ile 
    3530                 3535                 3540             


Phe Lys  Ser Cys Ala His Ser  Glu Gln Thr Leu Ser  Leu Thr Pro 
    3545                 3550                 3555             


Ala Lys  Pro Ile Arg Val Ser  Asp Ile Tyr Leu Ser  Lys Glu Gln 
    3560                 3565                 3570             


Ile Asn  Ser Gln Thr Pro Gly  Asn Leu Leu His Leu  Phe Phe Thr 
    3575                 3580                 3585             


Asn Val  Arg Pro Pro Lys Lys  Val Leu Glu Asp Gln  Leu Thr Gln 
    3590                 3595                 3600             


Ile Leu  Arg Lys Tyr Gly Val  Pro Lys Pro Lys Phe  Asp Lys Ser 
    3605                 3610                 3615             


Lys Tyr  Ser Lys Ala Gly Lys  Glu Gln His Pro Val  Lys Val Val 
    3620                 3625                 3630             


Ser Thr  Lys Arg Pro Ile Thr  Lys Pro Pro Ala Lys  Asp Lys Ala 
    3635                 3640                 3645             


Val Leu  Asn Ser Val Ser Arg  Thr Ala Leu Ser Glu  Lys Lys Pro 
    3650                 3655                 3660             


Thr Val  Lys Pro Lys Ser Pro  Glu Lys Ser Lys Pro  Asp Glu Lys 
    3665                 3670                 3675             


Asp Pro  Glu Lys Ser Pro Thr  Lys Lys Gln Glu Val  Pro Glu Glu 
    3680                 3685                 3690             


Lys Tyr  Leu Thr Leu Glu Gly  Phe His Lys Phe Val  Ile Asp Arg 
    3695                 3700                 3705             


Ala Arg  Gln Asp Ile Arg Ser  Val Trp Arg Ala Ile  Leu Ser Cys 
    3710                 3715                 3720             


Gly Tyr  Asp Leu His Phe Glu  Arg Cys Ala Cys Ile  Asp Val Arg 
    3725                 3730                 3735             


His Ala  Gln Lys Ala Ser Arg  Lys Trp Thr Leu Glu  Met Asp Val 
    3740                 3745                 3750             


Ala Leu  Val Gln Tyr Ile Asn  Gln Leu Cys Arg His  Leu Ala Ile 
    3755                 3760                 3765             


Thr Pro  Ala Arg Leu His Pro  His Glu Val Tyr Leu  Asp Pro Ala 
    3770                 3775                 3780             


Asp Ala  Ala Asp Pro Arg Val  Ala Cys Leu Leu Asn  Val Pro Ile 
    3785                 3790                 3795             


Glu Ser  Leu Arg Leu Arg Phe  Ala Leu Leu Gln Ser  Leu Asn Thr 
    3800                 3805                 3810             


Thr Leu  Glu Thr Phe Phe Leu  Pro Leu Val Glu Leu  Arg Gln Thr 
    3815                 3820                 3825             


Pro Met  Tyr Thr His Ser Ile  Ala Ala Leu Leu Lys  Glu Ala Lys 
    3830                 3835                 3840             


Gly Leu  Ile Phe Tyr Asp Thr  Lys Val Thr Val Met  Asn Arg Val 
    3845                 3850                 3855             


Leu Asn  Ala Thr Val Gln Arg  Thr Ala Asp His Ala  Ala Pro Glu 
    3860                 3865                 3870             


Ile Thr  Leu Asp Pro Leu Glu  Ile Val Gly Gly Glu  Ile Arg Ala 
    3875                 3880                 3885             


Ser Glu  Asn Ser Tyr Phe Cys  Gln Ala Ala Arg Gln  Leu Ala Ser 
    3890                 3895                 3900             


Val Pro  Ser Ser Gln Leu Cys  Val Lys Leu Ala Ser  Gly Gly Asp 
    3905                 3910                 3915             


Pro Thr  Tyr Ala Phe Asn Ile  Arg Phe Thr Gly Glu  Glu Val His 
    3920                 3925                 3930             


Gly Thr  Ser Gly Ser Phe Arg  His Phe Leu Trp Gln  Val Cys Lys 
    3935                 3940                 3945             


Glu Leu  Gln Ser Ser Ser Leu  Ser Leu Leu Leu Leu  Cys Pro Ser 
    3950                 3955                 3960             


Ser Ala  Val Asn Lys Asn Lys  Gly Lys Tyr Ile Leu  Thr Pro Ser 
    3965                 3970                 3975             


Pro Ile  Thr Tyr Gly Glu Glu  Gln Leu Leu His Phe  Leu Gly Gln 
    3980                 3985                 3990             


Leu Leu  Gly Ile Ala Ile Arg  Ala Asp Val Pro Leu  Pro Leu Asp 
    3995                 4000                 4005             


Leu Leu  Pro Ser Phe Trp Lys  Thr Leu Val Gly Glu  Pro Leu Asp 
    4010                 4015                 4020             


Pro Glu  Gln Asp Leu Gln Glu  Ala Asp Ile Leu Thr  Tyr Asn Tyr 
    4025                 4030                 4035             


Val Lys  Lys Phe Glu Ser Ile  Asn Asp Glu Thr Glu  Leu Glu Ala 
    4040                 4045                 4050             


Leu Cys  Ala Glu Ile Ala Ser  Gln His Leu Ala Thr  Glu Ser Pro 
    4055                 4060                 4065             


Asp Ser  Pro Asn Lys Pro Cys  Cys Arg Phe Thr Tyr  Leu Thr Met 
    4070                 4075                 4080             


Thr Gly  Glu Glu Val Glu Leu  Cys Ser Arg Gly Arg  His Ile Leu 
    4085                 4090                 4095             


Val Ala  Trp Glu Asn Lys Asp  Ile Tyr Ala Ala Ala  Ile Arg Ser 
    4100                 4105                 4110             


Leu Arg  Leu Arg Glu Leu Gln  Asn Val Glu Cys Val  Thr Ala Val 
    4115                 4120                 4125             


Arg Ala  Gly Leu Gly Ser Ile  Ile Pro Leu Gln Leu  Leu Thr Met 
    4130                 4135                 4140             


Leu Ser  Pro Leu Glu Met Glu  Leu Arg Thr Cys Gly  Leu Pro Tyr 
    4145                 4150                 4155             


Ile Asn  Leu Glu Phe Leu Lys  Ala His Thr Met Tyr  Gln Val Gly 
    4160                 4165                 4170             


Leu Met  Glu Thr Asp Gln His  Ile Glu Phe Phe Trp  Gly Ala Leu 
    4175                 4180                 4185             


Glu Met  Phe Thr Gln Glu Glu  Leu Cys Lys Phe Ile  Lys Phe Ala 
    4190                 4195                 4200             


Cys Asn  Gln Glu Arg Ile Pro  Phe Thr Cys Pro Cys  Lys Asp Gly 
    4205                 4210                 4215             


Gly Pro  Asp Thr Ala His Val  Pro Pro Tyr Pro Met  Lys Ile Ala 
    4220                 4225                 4230             


Pro Pro  Asp Gly Thr Ala Gly  Ser Pro Asp Ser Arg  Tyr Ile Arg 
    4235                 4240                 4245             


Val Glu  Thr Cys Met Phe Met  Ile Lys Leu Pro Gln  Tyr Ser Ser 
    4250                 4255                 4260             


Leu Glu  Ile Met Leu Glu Lys  Leu Arg Cys Ala Ile  His Tyr Arg 
    4265                 4270                 4275             


Glu Asp  Pro Leu Ser Gly 
    4280                 


<210>  4928
<211>  1572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HECW1__Homo_sapiens__NP_001273988

<400>  4928

Met Leu Leu His Leu Cys Ser Val Lys Asn Leu Tyr Gln Asn Arg Phe 
1               5                   10                  15      


Leu Gly Leu Ala Ala Met Ala Ser Pro Ser Arg Asn Ser Gln Ser Arg 
            20                  25                  30          


Arg Arg Cys Lys Glu Pro Leu Arg Tyr Ser Tyr Asn Pro Asp Gln Phe 
        35                  40                  45              


His Asn Met Asp Leu Arg Gly Gly Pro His Asp Gly Val Thr Ile Pro 
    50                  55                  60                  


Arg Ser Thr Ser Asp Thr Asp Leu Val Thr Ser Asp Ser Arg Ser Thr 
65                  70                  75                  80  


Leu Met Val Ser Ser Ser Tyr Tyr Ser Ile Gly His Ser Gln Asp Leu 
                85                  90                  95      


Val Ile His Trp Asp Ile Lys Glu Glu Val Asp Ala Gly Asp Trp Ile 
            100                 105                 110         


Gly Met Tyr Leu Ile Asp Glu Val Leu Ser Glu Asn Phe Leu Asp Tyr 
        115                 120                 125             


Lys Asn Arg Gly Val Asn Gly Ser His Arg Gly Gln Ile Ile Trp Lys 
    130                 135                 140                 


Ile Asp Ala Ser Ser Tyr Phe Val Glu Pro Glu Thr Lys Ile Cys Phe 
145                 150                 155                 160 


Lys Tyr Tyr His Gly Val Ser Gly Ala Leu Arg Ala Thr Thr Pro Ser 
                165                 170                 175     


Val Thr Val Lys Asn Ser Ala Ala Pro Ile Phe Lys Ser Ile Gly Ala 
            180                 185                 190         


Asp Glu Thr Val Gln Gly Gln Gly Ser Arg Arg Leu Ile Ser Phe Ser 
        195                 200                 205             


Leu Ser Asp Phe Gln Ala Met Gly Leu Lys Lys Gly Met Phe Phe Asn 
    210                 215                 220                 


Pro Asp Pro Tyr Leu Lys Ile Ser Ile Gln Pro Gly Lys His Ser Ile 
225                 230                 235                 240 


Phe Pro Ala Leu Pro His His Gly Gln Glu Arg Arg Ser Lys Ile Ile 
                245                 250                 255     


Gly Asn Thr Val Asn Pro Ile Trp Gln Ala Glu Gln Phe Ser Phe Val 
            260                 265                 270         


Ser Leu Pro Thr Asp Val Leu Glu Ile Glu Val Lys Asp Lys Phe Ala 
        275                 280                 285             


Lys Ser Arg Pro Ile Ile Lys Arg Phe Leu Gly Lys Leu Ser Met Pro 
    290                 295                 300                 


Val Gln Arg Leu Leu Glu Arg His Ala Ile Gly Asp Arg Val Val Ser 
305                 310                 315                 320 


Tyr Thr Leu Gly Arg Arg Leu Pro Thr Asp His Val Ser Gly Gln Leu 
                325                 330                 335     


Gln Phe Arg Phe Glu Ile Thr Ser Ser Ile His Pro Asp Asp Glu Glu 
            340                 345                 350         


Ile Ser Leu Ser Thr Glu Pro Glu Ser Ala Gln Ile Gln Asp Ser Pro 
        355                 360                 365             


Met Asn Asn Leu Met Glu Ser Gly Ser Gly Glu Pro Arg Ser Glu Ala 
    370                 375                 380                 


Pro Glu Ser Ser Glu Ser Trp Lys Pro Glu Gln Leu Gly Glu Gly Ser 
385                 390                 395                 400 


Val Pro Asp Gly Pro Gly Asn Gln Ser Ile Glu Leu Ser Arg Pro Ala 
                405                 410                 415     


Glu Glu Ala Ala Val Ile Thr Glu Ala Gly Asp Gln Gly Met Val Ser 
            420                 425                 430         


Val Gly Pro Glu Gly Ala Gly Glu Leu Leu Ala Gln Val Gln Lys Asp 
        435                 440                 445             


Ile Gln Pro Ala Pro Ser Ala Glu Glu Leu Ala Glu Gln Leu Asp Leu 
    450                 455                 460                 


Gly Glu Glu Ala Ser Ala Leu Leu Leu Glu Asp Gly Glu Ala Pro Ala 
465                 470                 475                 480 


Ser Thr Lys Glu Glu Pro Leu Glu Glu Glu Ala Thr Thr Gln Ser Arg 
                485                 490                 495     


Ala Gly Arg Glu Glu Glu Glu Lys Glu Gln Glu Glu Glu Gly Asp Val 
            500                 505                 510         


Ser Thr Leu Glu Gln Gly Glu Gly Arg Leu Gln Leu Arg Ala Ser Val 
        515                 520                 525             


Lys Arg Lys Ser Arg Pro Cys Ser Leu Pro Val Ser Glu Leu Glu Thr 
    530                 535                 540                 


Val Ile Ala Ser Ala Cys Gly Asp Pro Glu Thr Pro Arg Thr His Tyr 
545                 550                 555                 560 


Ile Arg Ile His Thr Leu Leu His Ser Met Pro Ser Ala Gln Gly Gly 
                565                 570                 575     


Ser Ala Ala Glu Glu Glu Asp Gly Ala Glu Glu Glu Ser Thr Leu Lys 
            580                 585                 590         


Asp Ser Ser Glu Lys Asp Gly Leu Ser Glu Val Asp Thr Val Ala Ala 
        595                 600                 605             


Asp Pro Ser Ala Leu Glu Glu Asp Arg Glu Glu Pro Glu Gly Ala Thr 
    610                 615                 620                 


Pro Gly Thr Ala His Pro Gly His Ser Gly Gly His Phe Pro Ser Leu 
625                 630                 635                 640 


Ala Asn Gly Ala Ala Gln Asp Gly Asp Thr His Pro Ser Thr Gly Ser 
                645                 650                 655     


Glu Ser Asp Ser Ser Pro Arg Gln Gly Gly Asp His Ser Cys Glu Gly 
            660                 665                 670         


Cys Asp Ala Ser Cys Cys Ser Pro Ser Cys Tyr Ser Ser Ser Cys Tyr 
        675                 680                 685             


Ser Thr Ser Cys Tyr Ser Ser Ser Cys Tyr Ser Ala Ser Cys Tyr Ser 
    690                 695                 700                 


Pro Ser Cys Tyr Asn Gly Asn Arg Phe Ala Ser His Thr Arg Phe Ser 
705                 710                 715                 720 


Ser Val Asp Ser Ala Lys Ile Ser Glu Ser Thr Val Phe Ser Ser Gln 
                725                 730                 735     


Asp Asp Glu Glu Glu Glu Asn Ser Ala Phe Glu Ser Val Pro Asp Ser 
            740                 745                 750         


Met Gln Ser Pro Glu Leu Asp Pro Glu Ser Thr Asn Gly Ala Gly Pro 
        755                 760                 765             


Trp Gln Asp Glu Leu Ala Ala Pro Ser Gly His Val Glu Arg Ser Pro 
    770                 775                 780                 


Glu Gly Leu Glu Ser Pro Val Ala Gly Pro Ser Asn Arg Arg Glu Asp 
785                 790                 795                 800 


Trp Glu Ala Arg Ile Asp Ser His Gly Arg Val Phe Tyr Val Asp His 
                805                 810                 815     


Val Asn Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Ala Ala Thr Pro 
            820                 825                 830         


Asp Gly Met Arg Arg Ser Gly Ser Ile Gln Gln Met Glu Gln Leu Asn 
        835                 840                 845             


Arg Arg Tyr Gln Asn Ile Gln Arg Thr Ile Ala Thr Glu Arg Ser Glu 
    850                 855                 860                 


Glu Asp Ser Gly Ser Gln Ser Cys Glu Gln Ala Pro Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Gly Gly Ser Asp Ser Glu Ala Glu Ser Ser Gln Ser Ser Leu 
                885                 890                 895     


Asp Leu Arg Arg Glu Gly Ser Leu Ser Pro Val Asn Ser Gln Lys Ile 
            900                 905                 910         


Thr Leu Leu Leu Gln Ser Pro Ala Val Lys Phe Ile Thr Asn Pro Glu 
        915                 920                 925             


Phe Phe Thr Val Leu His Ala Asn Tyr Ser Ala Tyr Arg Val Phe Thr 
    930                 935                 940                 


Ser Ser Thr Cys Leu Lys His Met Ile Leu Lys Val Arg Arg Asp Ala 
945                 950                 955                 960 


Arg Asn Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Asn Phe Ile 
                965                 970                 975     


Asn Met Phe Ala Asp Thr Arg Leu Glu Leu Pro Arg Gly Trp Glu Ile 
            980                 985                 990         


Lys Thr Asp Gln Gln Gly Lys Ser  Phe Phe Val Asp His  Asn Ser Arg 
        995                 1000                 1005             


Ala Thr  Thr Phe Ile Asp Pro  Arg Ile Pro Leu Gln  Asn Gly Arg 
    1010                 1015                 1020             


Leu Pro  Asn His Leu Thr His  Arg Gln His Leu Gln  Arg Leu Arg 
    1025                 1030                 1035             


Ser Tyr  Ser Ala Gly Glu Ala  Ser Glu Val Ser Arg  Asn Arg Gly 
    1040                 1045                 1050             


Ala Ser  Leu Leu Ala Arg Pro  Gly His Ser Leu Val  Ala Ala Ile 
    1055                 1060                 1065             


Arg Ser  Gln His Gln His Glu  Ser Leu Pro Leu Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Met Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Ser Leu  Ala Arg Asn His Thr  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  His Tyr Ile Arg Thr  Glu Gly Asn His Gly  Leu Glu Lys 
    1115                 1120                 1125             


Leu Ser  Cys Asp Ala Asp Leu  Val Ile Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Leu Gln Ala Ala  Phe His Pro 
    1145                 1150                 1155             


Gly Tyr  Ser Phe Ser Pro Arg  Cys Ser Pro Cys Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Leu Gln Arg  Ala Ser Ala Arg Ala  Pro Ser Pro 
    1175                 1180                 1185             


Tyr Arg  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Ala Lys Gly Phe Gly  Gln Gly Pro Gly Lys  Ile Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Gly Thr Phe  Asn Gln Val 
    1220                 1225                 1230             


Met Ala  Tyr Ser Arg Lys Glu  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Leu Ser  Gln Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Glu Asn His Leu Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Leu Pro  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asn Ile  Thr Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Val 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Ser  Gly Gly Ala Asn Thr  Gln Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Val Glu  Arg Gly Val Val Gln  Gln Thr Glu Ala Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ser  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Asn Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Gly His  Leu Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Val Pro Tyr Glu Gly  Phe Ala Ala Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Leu  Arg Arg Phe Cys Ile  Glu Lys Trp Gly Lys  Ile Thr Ser 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Tyr Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         


<210>  4929
<211>  1572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HECW2__Homo_sapiens__NP_065811

<400>  4929

Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met Glu Pro Glu Ile Lys Ile Cys Phe Lys Tyr Tyr His 
    130                 135                 140                 


Gly Ile Ser Gly Ala Leu Arg Ala Thr Thr Pro Cys Ile Thr Val Lys 
145                 150                 155                 160 


Asn Pro Ala Val Met Met Gly Ala Glu Gly Met Glu Gly Gly Ala Ser 
                165                 170                 175     


Gly Asn Leu His Ser Arg Lys Leu Val Ser Phe Thr Leu Ser Asp Leu 
            180                 185                 190         


Arg Ala Val Gly Leu Lys Lys Gly Met Phe Phe Asn Pro Asp Pro Tyr 
        195                 200                 205             


Leu Lys Met Ser Ile Gln Pro Gly Lys Lys Ser Ser Phe Pro Thr Cys 
    210                 215                 220                 


Ala His His Gly Gln Glu Arg Arg Ser Thr Ile Ile Ser Asn Thr Thr 
225                 230                 235                 240 


Asn Pro Ile Trp His Arg Glu Lys Tyr Ser Phe Phe Ala Leu Leu Thr 
                245                 250                 255     


Asp Val Leu Glu Ile Glu Ile Lys Asp Lys Phe Ala Lys Ser Arg Pro 
            260                 265                 270         


Ile Ile Lys Arg Phe Leu Gly Lys Leu Thr Ile Pro Val Gln Arg Leu 
        275                 280                 285             


Leu Glu Arg Gln Ala Ile Gly Asp Gln Met Leu Ser Tyr Asn Leu Gly 
    290                 295                 300                 


Arg Arg Leu Pro Ala Asp His Val Ser Gly Tyr Leu Gln Phe Lys Val 
305                 310                 315                 320 


Glu Val Thr Ser Ser Val His Glu Asp Ala Ser Pro Glu Ala Val Gly 
                325                 330                 335     


Thr Ile Leu Gly Val Asn Ser Val Asn Gly Asp Leu Gly Ser Pro Ser 
            340                 345                 350         


Asp Asp Glu Asp Met Pro Gly Ser His His Asp Ser Gln Val Cys Ser 
        355                 360                 365             


Asn Gly Pro Val Ser Glu Asp Ser Ala Ala Asp Gly Thr Pro Lys His 
    370                 375                 380                 


Ser Phe Arg Thr Ser Ser Thr Leu Glu Ile Asp Thr Glu Glu Leu Thr 
385                 390                 395                 400 


Ser Thr Ser Ser Arg Thr Ser Pro Pro Arg Gly Arg Gln Asp Ser Leu 
                405                 410                 415     


Asn Asp Tyr Leu Asp Ala Ile Glu His Asn Gly His Ser Arg Pro Gly 
            420                 425                 430         


Thr Ala Thr Cys Ser Glu Arg Ser Met Gly Ala Ser Pro Lys Leu Arg 
        435                 440                 445             


Ser Ser Phe Pro Thr Asp Thr Arg Leu Asn Ala Met Leu His Ile Asp 
    450                 455                 460                 


Ser Asp Glu Glu Asp His Glu Phe Gln Gln Asp Leu Gly Tyr Pro Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Glu Gly Gly Leu Ile Met Phe Ser Arg Ala Ser Arg 
                485                 490                 495     


Ala Asp Asp Gly Ser Leu Thr Ser Gln Thr Lys Leu Glu Asp Asn Pro 
            500                 505                 510         


Val Glu Asn Glu Glu Ala Ser Thr His Glu Ala Ala Ser Phe Glu Asp 
        515                 520                 525             


Lys Pro Glu Asn Leu Pro Glu Leu Ala Glu Ser Ser Leu Pro Ala Gly 
    530                 535                 540                 


Pro Ala Pro Glu Glu Gly Glu Gly Gly Pro Glu Pro Gln Pro Ser Ala 
545                 550                 555                 560 


Asp Gln Gly Ser Ala Glu Leu Cys Gly Ser Gln Glu Val Asp Gln Pro 
                565                 570                 575     


Thr Ser Gly Ala Asp Thr Gly Thr Ser Asp Ala Ser Gly Gly Ser Arg 
            580                 585                 590         


Arg Ala Val Ser Glu Thr Glu Ser Leu Asp Gln Gly Ser Glu Pro Ser 
        595                 600                 605             


Gln Val Ser Ser Glu Thr Glu Pro Ser Asp Pro Ala Arg Thr Glu Ser 
    610                 615                 620                 


Val Ser Glu Ala Ser Thr Arg Pro Glu Gly Glu Ser Asp Leu Glu Cys 
625                 630                 635                 640 


Ala Asp Ser Ser Cys Asn Glu Ser Val Thr Thr Gln Leu Ser Ser Val 
                645                 650                 655     


Asp Thr Arg Cys Ser Ser Leu Glu Ser Ala Arg Phe Pro Glu Thr Pro 
            660                 665                 670         


Ala Phe Ser Ser Gln Glu Glu Glu Asp Gly Ala Cys Ala Ala Glu Pro 
        675                 680                 685             


Thr Ser Ser Gly Pro Ala Glu Gly Ser Gln Glu Ser Val Cys Thr Ala 
    690                 695                 700                 


Gly Ser Leu Pro Val Val Gln Val Pro Ser Gly Glu Asp Glu Gly Pro 
705                 710                 715                 720 


Gly Ala Glu Ser Ala Thr Val Pro Asp Gln Glu Glu Leu Gly Glu Val 
                725                 730                 735     


Trp Gln Arg Arg Gly Ser Leu Glu Gly Ala Ala Ala Ala Ala Glu Ser 
            740                 745                 750         


Pro Pro Gln Glu Glu Gly Ser Ala Gly Glu Ala Gln Gly Thr Cys Glu 
        755                 760                 765             


Gly Ala Thr Ala Gln Glu Glu Gly Ala Thr Gly Gly Ser Gln Ala Asn 
    770                 775                 780                 


Gly His Gln Pro Leu Arg Ser Leu Pro Ser Val Arg Gln Asp Val Ser 
785                 790                 795                 800 


Arg Tyr Gln Arg Val Asp Glu Ala Leu Pro Pro Asn Trp Glu Ala Arg 
                805                 810                 815     


Ile Asp Ser His Gly Arg Ile Phe Tyr Val Asp His Val Asn Arg Thr 
            820                 825                 830         


Thr Thr Trp Gln Arg Pro Thr Ala Pro Pro Ala Pro Gln Val Leu Gln 
        835                 840                 845             


Arg Ser Asn Ser Ile Gln Gln Met Glu Gln Leu Asn Arg Arg Tyr Gln 
    850                 855                 860                 


Ser Ile Arg Arg Thr Met Thr Asn Glu Arg Pro Glu Glu Asn Thr Asn 
865                 870                 875                 880 


Ala Ile Asp Gly Ala Gly Glu Glu Ala Asp Phe His Gln Ala Ser Ala 
                885                 890                 895     


Asp Phe Arg Arg Glu Asn Ile Leu Pro His Ser Thr Ser Arg Ser Arg 
            900                 905                 910         


Ile Thr Leu Leu Leu Gln Ser Pro Pro Val Lys Phe Leu Ile Ser Pro 
        915                 920                 925             


Glu Phe Phe Thr Val Leu His Ser Asn Pro Ser Ala Tyr Arg Met Phe 
    930                 935                 940                 


Thr Asn Asn Thr Cys Leu Lys His Met Ile Thr Lys Val Arg Arg Asp 
945                 950                 955                 960 


Thr His His Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Gly Phe 
                965                 970                 975     


Leu Asn Met Phe Ala Asn Lys Gln Leu Glu Leu Pro Arg Gly Trp Glu 
            980                 985                 990         


Met Lys His Asp His Gln Gly Lys  Ala Phe Phe Val Asp  His Asn Ser 
        995                 1000                 1005             


Arg Thr  Thr Thr Phe Ile Asp  Pro Arg Leu Pro Leu  Gln Ser Ser 
    1010                 1015                 1020             


Arg Pro  Thr Ser Ala Leu Val  His Arg Gln His Leu  Thr Arg Gln 
    1025                 1030                 1035             


Arg Ser  His Ser Ala Gly Glu  Val Gly Glu Asp Ser  Arg His Ala 
    1040                 1045                 1050             


Gly Pro  Pro Val Leu Pro Arg  Pro Ser Ser Thr Phe  Asn Thr Val 
    1055                 1060                 1065             


Ser Arg  Pro Gln Tyr Gln Asp  Met Val Pro Val Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Ile Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Asp Leu  Thr Arg Asn His Ser  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Gln Phe Ile Arg Thr  Glu Gly Thr Pro Gly  Leu Val Arg 
    1115                 1120                 1125             


Leu Ser  Ser Asp Ala Asp Leu  Val Met Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Pro His Ala Leu  Leu His Pro 
    1145                 1150                 1155             


Ser Tyr  Cys Gln Ser Pro Arg  Gly Ser Pro Val Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Thr Gln Arg  Ala Asn Ala Arg Ala  Pro Ala Pro 
    1175                 1180                 1185             


Tyr Lys  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Thr Lys Gly Tyr Gly  Gln Gly Pro Gly Lys  Leu Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Asp Ala Phe  Asn Gln Ile 
    1220                 1225                 1230             


Met Gly  Tyr Ser Arg Lys Asp  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Val Ser  Arg Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Asp Asn His His Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Ile Leu  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asp Ile  His Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Ile 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Pro  Gly Gly Ala Asn Ile  Pro Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Val Val Gln  Gln Thr Glu Ser Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ala  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Ser Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Asn His  Ile Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Ile Pro Tyr Glu Gly  Phe Ala Ser Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Pro  Arg Arg Phe Cys Val  Glu Lys Trp Gly Lys  Ile Thr Ala 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Phe Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         


<210>  4930
<211>  1381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEG1__Homo_sapiens__NP_065784

<400>  4930

Met Ala Ser Pro Arg Ala Ser Arg Trp Pro Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Leu Pro Pro Ala Ala Pro Gly Thr Arg Asp 
            20                  25                  30          


Pro Pro Pro Ser Pro Ala Arg Arg Ala Leu Ser Leu Ala Pro Leu Ala 
        35                  40                  45              


Gly Ala Gly Leu Glu Leu Gln Leu Glu Arg Arg Pro Glu Arg Glu Pro 
    50                  55                  60                  


Pro Pro Thr Pro Pro Arg Glu Arg Arg Gly Pro Ala Thr Pro Gly Pro 
65                  70                  75                  80  


Ser Tyr Arg Ala Pro Glu Pro Gly Ala Ala Thr Gln Arg Gly Pro Ser 
                85                  90                  95      


Gly Arg Ala Pro Arg Gly Gly Ser Ala Asp Ala Ala Trp Lys His Trp 
            100                 105                 110         


Pro Glu Ser Asn Thr Glu Ala His Val Glu Asn Ile Thr Phe Tyr Gln 
        115                 120                 125             


Asn Gln Glu Asp Phe Ser Thr Val Ser Ser Lys Glu Gly Val Met Val 
    130                 135                 140                 


Gln Thr Ser Gly Lys Ser His Ala Ala Ser Asp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu Leu Ala Glu Thr Ala Asp Ala Arg Gly Arg Ser Gly Ser Ser 
                165                 170                 175     


Ser Arg Thr Asn Phe Thr Ile Leu Pro Val Gly Tyr Ser Leu Glu Ile 
            180                 185                 190         


Ala Thr Ala Leu Thr Ser Gln Ser Gly Asn Leu Ala Ser Glu Ser Leu 
        195                 200                 205             


His Leu Pro Ser Ser Ser Ser Glu Phe Asp Glu Arg Ile Ala Ala Phe 
    210                 215                 220                 


Gln Thr Lys Ser Gly Thr Ala Ser Glu Met Gly Thr Glu Arg Ala Met 
225                 230                 235                 240 


Gly Leu Ser Glu Glu Trp Thr Val His Ser Gln Glu Ala Thr Thr Ser 
                245                 250                 255     


Ala Trp Ser Pro Ser Phe Leu Pro Ala Leu Glu Met Gly Glu Leu Thr 
            260                 265                 270         


Thr Pro Ser Arg Lys Arg Asn Ser Ser Gly Pro Asp Leu Ser Trp Leu 
        275                 280                 285             


His Phe Tyr Arg Thr Ala Ala Ser Ser Pro Leu Leu Asp Leu Ser Ser 
    290                 295                 300                 


Ser Ser Glu Ser Thr Glu Lys Leu Asn Asn Ser Thr Gly Leu Gln Ser 
305                 310                 315                 320 


Ser Ser Val Ser Gln Thr Lys Thr Met His Val Ala Thr Val Phe Thr 
                325                 330                 335     


Asp Gly Gly Pro Arg Thr Leu Arg Ser Leu Thr Val Ser Leu Gly Pro 
            340                 345                 350         


Val Ser Lys Thr Glu Gly Phe Pro Lys Asp Ser Arg Ile Ala Thr Thr 
        355                 360                 365             


Ser Ser Ser Val Leu Leu Ser Pro Ser Ala Val Glu Ser Arg Arg Asn 
    370                 375                 380                 


Ser Arg Val Thr Gly Asn Pro Gly Asp Glu Glu Phe Ile Glu Pro Ser 
385                 390                 395                 400 


Thr Glu Asn Glu Phe Gly Leu Thr Ser Leu Arg Trp Gln Asn Asp Ser 
                405                 410                 415     


Pro Thr Phe Gly Glu His Gln Leu Ala Ser Ser Ser Glu Val Gln Asn 
            420                 425                 430         


Gly Ser Pro Met Ser Gln Thr Glu Thr Val Ser Arg Ser Val Ala Pro 
        435                 440                 445             


Met Arg Gly Gly Glu Ile Thr Ala His Trp Leu Leu Thr Asn Ser Thr 
    450                 455                 460                 


Thr Ser Ala Asp Val Thr Gly Ser Ser Ala Ser Tyr Pro Glu Gly Val 
465                 470                 475                 480 


Asn Ala Ser Val Leu Thr Gln Phe Ser Asp Ser Thr Val Gln Ser Gly 
                485                 490                 495     


Gly Ser His Thr Ala Leu Gly Asp Arg Ser Tyr Ser Glu Ser Ser Ser 
            500                 505                 510         


Thr Ser Ser Ser Glu Ser Leu Asn Ser Ser Ala Pro Arg Gly Glu Arg 
        515                 520                 525             


Ser Ile Ala Gly Ile Ser Tyr Gly Gln Val Arg Gly Thr Ala Ile Glu 
    530                 535                 540                 


Gln Arg Thr Ser Ser Asp His Thr Asp His Thr Tyr Leu Ser Ser Thr 
545                 550                 555                 560 


Phe Thr Lys Gly Glu Arg Ala Leu Leu Ser Ile Thr Asp Asn Ser Ser 
                565                 570                 575     


Ser Ser Asp Ile Val Glu Ser Ser Thr Ser Tyr Ile Lys Ile Ser Asn 
            580                 585                 590         


Ser Ser His Ser Glu Tyr Ser Ser Phe Phe His Ala Gln Thr Glu Arg 
        595                 600                 605             


Ser Asn Ile Ser Ser Tyr Asp Gly Glu Tyr Ala Gln Pro Ser Thr Glu 
    610                 615                 620                 


Ser Pro Val Leu His Thr Ser Asn Leu Pro Ser Tyr Thr Pro Thr Ile 
625                 630                 635                 640 


Asn Met Pro Asn Thr Ser Val Val Leu Asp Thr Asp Ala Glu Phe Val 
                645                 650                 655     


Ser Asp Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
            660                 665                 670         


Gly Pro Pro Leu Pro Leu Pro Ser Val Ser Gln Ser His His Leu Phe 
        675                 680                 685             


Ser Ser Ile Leu Pro Ser Thr Arg Ala Ser Val His Leu Leu Lys Ser 
    690                 695                 700                 


Thr Ser Asp Ala Ser Thr Pro Trp Ser Ser Ser Pro Ser Pro Leu Pro 
705                 710                 715                 720 


Val Ser Leu Thr Thr Ser Thr Ser Ala Pro Leu Ser Val Ser Gln Thr 
                725                 730                 735     


Thr Leu Pro Gln Ser Ser Ser Thr Pro Val Leu Pro Arg Ala Arg Glu 
            740                 745                 750         


Thr Pro Val Thr Ser Phe Gln Thr Ser Thr Met Thr Ser Phe Met Thr 
        755                 760                 765             


Met Leu His Ser Ser Gln Thr Ala Asp Leu Lys Ser Gln Ser Thr Pro 
    770                 775                 780                 


His Gln Glu Lys Val Ile Thr Glu Ser Lys Ser Pro Ser Leu Val Ser 
785                 790                 795                 800 


Leu Pro Thr Glu Ser Thr Lys Ala Val Thr Thr Asn Ser Pro Leu Pro 
                805                 810                 815     


Pro Ser Leu Thr Glu Ser Ser Thr Glu Gln Thr Leu Pro Ala Thr Ser 
            820                 825                 830         


Thr Asn Leu Ala Gln Met Ser Pro Thr Phe Thr Thr Thr Ile Leu Lys 
        835                 840                 845             


Thr Ser Gln Pro Leu Met Thr Thr Pro Gly Thr Leu Ser Ser Thr Ala 
    850                 855                 860                 


Ser Leu Val Thr Gly Pro Ile Ala Val Gln Thr Thr Ala Gly Lys Gln 
865                 870                 875                 880 


Leu Ser Leu Thr His Pro Glu Ile Leu Val Pro Gln Ile Ser Thr Glu 
                885                 890                 895     


Gly Gly Ile Ser Thr Glu Arg Asn Arg Val Ile Val Asp Ala Thr Thr 
            900                 905                 910         


Gly Leu Ile Pro Leu Thr Ser Val Pro Thr Ser Ala Lys Glu Met Thr 
        915                 920                 925             


Thr Lys Leu Gly Val Thr Ala Glu Tyr Ser Pro Ala Ser Arg Ser Leu 
    930                 935                 940                 


Gly Thr Ser Pro Ser Pro Gln Thr Thr Val Val Ser Thr Ala Glu Asp 
945                 950                 955                 960 


Leu Ala Pro Lys Ser Ala Thr Phe Ala Val Gln Ser Ser Thr Gln Ser 
                965                 970                 975     


Pro Thr Thr Val Ser Ser Ser Ala Ser Val Asn Ser Cys Ala Val Asn 
            980                 985                 990         


Pro Cys Leu His Asn Gly Glu Cys  Val Ala Asp Asn Thr  Ser Arg Gly 
        995                 1000                 1005             


Tyr His  Cys Arg Cys Pro Pro  Ser Trp Gln Gly Asp  Asp Cys Ser 
    1010                 1015                 1020             


Val Asp  Val Asn Glu Cys Leu  Ser Asn Pro Cys Pro  Ser Thr Ala 
    1025                 1030                 1035             


Met Cys  Asn Asn Thr Gln Gly  Ser Phe Ile Cys Lys  Cys Pro Val 
    1040                 1045                 1050             


Gly Tyr  Gln Leu Glu Lys Gly  Ile Cys Asn Leu Val  Arg Thr Phe 
    1055                 1060                 1065             


Val Thr  Glu Phe Lys Leu Lys  Arg Thr Phe Leu Asn  Thr Thr Val 
    1070                 1075                 1080             


Glu Lys  His Ser Asp Leu Gln  Glu Val Glu Asn Glu  Ile Thr Lys 
    1085                 1090                 1095             


Thr Leu  Asn Met Cys Phe Ser  Ala Leu Pro Ser Tyr  Ile Arg Ser 
    1100                 1105                 1110             


Thr Val  His Ala Ser Arg Glu  Ser Asn Ala Val Val  Ile Ser Leu 
    1115                 1120                 1125             


Gln Thr  Thr Phe Ser Leu Ala  Ser Asn Val Thr Leu  Phe Asp Leu 
    1130                 1135                 1140             


Ala Asp  Arg Met Gln Lys Cys  Val Asn Ser Cys Lys  Ser Ser Ala 
    1145                 1150                 1155             


Glu Val  Cys Gln Leu Leu Gly  Ser Gln Arg Arg Ile  Phe Arg Ala 
    1160                 1165                 1170             


Gly Ser  Leu Cys Lys Arg Lys  Ser Pro Glu Cys Asp  Lys Asp Thr 
    1175                 1180                 1185             


Ser Ile  Cys Thr Asp Leu Asp  Gly Val Ala Leu Cys  Gln Cys Lys 
    1190                 1195                 1200             


Ser Gly  Tyr Phe Gln Phe Asn  Lys Met Asp His Ser  Cys Arg Ala 
    1205                 1210                 1215             


Cys Glu  Asp Gly Tyr Arg Leu  Glu Asn Glu Thr Cys  Met Ser Cys 
    1220                 1225                 1230             


Pro Phe  Gly Leu Gly Gly Leu  Asn Cys Gly Asn Pro  Tyr Gln Leu 
    1235                 1240                 1245             


Ile Thr  Val Val Ile Ala Ala  Ala Gly Gly Gly Leu  Leu Leu Ile 
    1250                 1255                 1260             


Leu Gly  Ile Ala Leu Ile Val  Thr Cys Cys Arg Lys  Asn Lys Asn 
    1265                 1270                 1275             


Asp Ile  Ser Lys Leu Ile Phe  Lys Ser Gly Asp Phe  Gln Met Ser 
    1280                 1285                 1290             


Pro Tyr  Ala Glu Tyr Pro Lys  Asn Pro Arg Ser Gln  Glu Trp Gly 
    1295                 1300                 1305             


Arg Glu  Ala Ile Glu Met His  Glu Asn Gly Ser Thr  Lys Asn Leu 
    1310                 1315                 1320             


Leu Gln  Met Thr Asp Val Tyr  Tyr Ser Pro Thr Ser  Val Arg Asn 
    1325                 1330                 1335             


Pro Glu  Leu Glu Arg Asn Gly  Leu Tyr Pro Ala Tyr  Thr Gly Leu 
    1340                 1345                 1350             


Pro Gly  Ser Arg His Ser Cys  Ile Phe Pro Gly Gln  Tyr Asn Pro 
    1355                 1360                 1365             


Ser Phe  Ile Ser Asp Glu Ser  Arg Arg Arg Asp Tyr  Phe 
    1370                 1375                 1380     


<210>  4931
<211>  884
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HELLS__Homo_sapiens__NP_001275996

<400>  4931

Met Pro Ala Glu Arg Pro Ala Gly Ser Gly Gly Ser Glu Ala Pro Ala 
1               5                   10                  15      


Met Val Glu Gln Leu Asp Thr Ala Val Ile Thr Pro Ala Met Leu Glu 
            20                  25                  30          


Glu Glu Glu Gln Leu Glu Ala Ala Gly Leu Glu Arg Glu Arg Lys Met 
        35                  40                  45              


Leu Glu Lys Ala Arg Met Ser Trp Asp Arg Glu Ser Thr Glu Ile Arg 
    50                  55                  60                  


Tyr Arg Arg Leu Gln His Leu Leu Glu Lys Ser Asn Ile Tyr Ser Lys 
65                  70                  75                  80  


Phe Leu Leu Thr Lys Met Glu Gln Gln Gln Leu Glu Glu Gln Lys Lys 
                85                  90                  95      


Lys Glu Lys Leu Glu Arg Lys Lys Glu Ser Leu Lys Val Lys Lys Gly 
            100                 105                 110         


Lys Asn Ser Ile Asp Ala Ser Glu Glu Lys Pro Val Met Arg Lys Lys 
        115                 120                 125             


Arg Gly Arg Glu Asp Glu Ser Tyr Asn Ile Ser Glu Val Met Ser Lys 
    130                 135                 140                 


Glu Glu Ile Leu Ser Val Ala Lys Lys Asn Lys Lys Glu Asn Glu Asp 
145                 150                 155                 160 


Glu Asn Ser Ser Ser Thr Asn Leu Cys Val Glu Asp Leu Gln Lys Asn 
                165                 170                 175     


Lys Asp Ser Asn Ser Ile Ile Lys Asp Arg Leu Ser Glu Thr Val Arg 
            180                 185                 190         


Gln Asn Thr Lys Phe Phe Phe Asp Pro Val Arg Lys Cys Asn Gly Gln 
        195                 200                 205             


Pro Val Pro Phe Gln Gln Pro Lys His Phe Thr Gly Gly Val Met Arg 
    210                 215                 220                 


Trp Tyr Gln Val Glu Gly Met Glu Trp Leu Arg Met Leu Trp Glu Asn 
225                 230                 235                 240 


Gly Ile Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val 
                245                 250                 255     


Gln Cys Ile Ala Thr Ile Ala Leu Met Ile Gln Arg Gly Val Pro Gly 
            260                 265                 270         


Pro Phe Leu Val Cys Gly Pro Leu Ser Thr Leu Pro Asn Trp Met Ala 
        275                 280                 285             


Glu Phe Lys Arg Phe Thr Pro Asp Ile Pro Thr Met Leu Tyr His Gly 
    290                 295                 300                 


Thr Gln Glu Glu Arg Gln Lys Leu Val Arg Asn Ile Tyr Lys Arg Lys 
305                 310                 315                 320 


Gly Thr Leu Gln Ile His Pro Val Val Ile Thr Ser Phe Glu Ile Ala 
                325                 330                 335     


Met Arg Asp Arg Asn Ala Leu Gln His Cys Tyr Trp Lys Tyr Leu Ile 
            340                 345                 350         


Val Asp Glu Gly His Arg Ile Lys Asn Met Lys Cys Arg Leu Ile Arg 
        355                 360                 365             


Glu Leu Lys Arg Phe Asn Ala Asp Asn Lys Leu Leu Leu Thr Gly Thr 
    370                 375                 380                 


Pro Leu Gln Asn Asn Leu Ser Glu Leu Trp Ser Leu Leu Asn Phe Leu 
385                 390                 395                 400 


Leu Pro Asp Val Phe Asp Asp Leu Lys Ser Phe Glu Ser Trp Phe Asp 
                405                 410                 415     


Ile Thr Ser Leu Ser Glu Thr Ala Glu Asp Ile Ile Ala Lys Glu Arg 
            420                 425                 430         


Glu Gln Asn Val Leu His Met Leu His Gln Glu Arg Ile Pro Arg Met 
        435                 440                 445             


Tyr Val Ser Glu Phe Thr Asp Glu Gly Phe Phe Glu Gly Lys Leu Pro 
    450                 455                 460                 


Ser Arg Lys Asp Leu Tyr Asp Ile Arg Pro Tyr Glu Asn Thr Tyr Leu 
465                 470                 475                 480 


Leu Lys Leu His Thr Asn Phe Glu Ile Leu Thr Pro Phe Leu Leu Arg 
                485                 490                 495     


Arg Leu Lys Ser Asp Val Ala Leu Glu Val Pro Pro Lys Arg Glu Val 
            500                 505                 510         


Val Val Tyr Ala Pro Leu Ser Lys Lys Gln Glu Ile Phe Tyr Thr Ala 
        515                 520                 525             


Ile Val Asn Arg Thr Ile Ala Asn Met Phe Gly Ser Ser Glu Lys Glu 
    530                 535                 540                 


Thr Ile Glu Leu Ser Pro Thr Gly Arg Pro Lys Arg Arg Thr Arg Lys 
545                 550                 555                 560 


Ser Ile Asn Tyr Ser Lys Ile Asp Asp Phe Pro Asn Glu Leu Glu Lys 
                565                 570                 575     


Leu Ile Ser Gln Ile Gln Pro Glu Val Asp Arg Glu Arg Ala Val Val 
            580                 585                 590         


Glu Val Asn Ile Pro Val Glu Ser Glu Val Asn Leu Lys Leu Gln Asn 
        595                 600                 605             


Ile Met Met Leu Leu Arg Lys Cys Cys Asn His Pro Tyr Leu Ile Glu 
    610                 615                 620                 


Tyr Pro Ile Asp Pro Val Thr Gln Glu Phe Lys Ile Asp Glu Glu Leu 
625                 630                 635                 640 


Val Thr Asn Ser Gly Lys Phe Leu Ile Leu Asp Arg Met Leu Pro Glu 
                645                 650                 655     


Leu Lys Lys Arg Gly His Lys Val Leu Leu Phe Ser Gln Met Thr Ser 
            660                 665                 670         


Met Leu Asp Ile Leu Met Asp Tyr Cys His Leu Arg Asp Phe Asn Phe 
        675                 680                 685             


Ser Arg Leu Asp Gly Ser Met Ser Tyr Ser Glu Arg Glu Lys Asn Met 
    690                 695                 700                 


His Ser Phe Asn Thr Asp Pro Glu Val Phe Ile Phe Leu Val Ser Thr 
705                 710                 715                 720 


Arg Ala Gly Gly Leu Gly Ile Asn Leu Thr Ala Ala Asp Thr Val Ile 
                725                 730                 735     


Ile Tyr Asp Ser Asp Trp Asn Pro Gln Ser Asp Leu Gln Ala Gln Asp 
            740                 745                 750         


Arg Cys His Arg Ile Gly Gln Thr Lys Pro Val Val Val Tyr Arg Leu 
        755                 760                 765             


Val Thr Ala Asn Thr Ile Asp Gln Lys Ile Val Glu Arg Ala Ala Ala 
    770                 775                 780                 


Lys Arg Lys Leu Glu Lys Leu Ile Ile His Lys Asn His Phe Lys Gly 
785                 790                 795                 800 


Gly Gln Ser Gly Leu Asn Leu Ser Lys Asn Phe Leu Asp Pro Lys Glu 
                805                 810                 815     


Leu Met Glu Leu Leu Lys Ser Arg Asp Tyr Glu Arg Glu Ile Lys Gly 
            820                 825                 830         


Ser Arg Glu Lys Val Ile Ser Asp Lys Asp Leu Glu Leu Leu Leu Asp 
        835                 840                 845             


Arg Ser Asp Leu Ile Asp Gln Met Asn Ala Ser Gly Pro Ile Lys Glu 
    850                 855                 860                 


Lys Met Gly Ile Phe Lys Ile Leu Glu Asn Ser Glu Asp Ser Ser Pro 
865                 870                 875                 880 


Glu Cys Leu Phe 
                


<210>  4932
<211>  1101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HELQ__Homo_sapiens__NP_598375

<400>  4932

Met Asp Glu Cys Gly Ser Arg Ile Arg Arg Arg Val Ser Leu Pro Lys 
1               5                   10                  15      


Arg Asn Arg Pro Ser Leu Gly Cys Ile Phe Gly Ala Pro Thr Ala Ala 
            20                  25                  30          


Glu Leu Glu Pro Gly Asp Glu Gly Lys Glu Glu Glu Glu Met Val Ala 
        35                  40                  45              


Glu Asn Arg Arg Arg Lys Thr Ala Gly Val Leu Pro Val Glu Val Gln 
    50                  55                  60                  


Pro Leu Leu Leu Ser Asp Ser Pro Glu Cys Leu Val Leu Gly Gly Gly 
65                  70                  75                  80  


Asp Thr Asn Pro Asp Leu Leu Arg His Met Pro Thr Asp Arg Gly Val 
                85                  90                  95      


Gly Asp Gln Pro Asn Asp Ser Glu Val Asp Met Phe Gly Asp Tyr Asp 
            100                 105                 110         


Ser Phe Thr Glu Asn Ser Phe Ile Ala Gln Val Asp Asp Leu Glu Gln 
        115                 120                 125             


Lys Tyr Met Gln Leu Pro Glu His Lys Lys His Ala Thr Asp Phe Ala 
    130                 135                 140                 


Thr Glu Asn Leu Cys Ser Glu Ser Ile Lys Asn Lys Leu Ser Ile Thr 
145                 150                 155                 160 


Thr Ile Gly Asn Leu Thr Glu Leu Gln Thr Asp Lys His Thr Glu Asn 
                165                 170                 175     


Gln Ser Gly Tyr Glu Gly Val Thr Ile Glu Pro Gly Ala Asp Leu Leu 
            180                 185                 190         


Tyr Asp Val Pro Ser Ser Gln Ala Ile Tyr Phe Glu Asn Leu Gln Asn 
        195                 200                 205             


Ser Ser Asn Asp Leu Gly Asp His Ser Met Lys Glu Arg Asp Trp Lys 
    210                 215                 220                 


Ser Ser Ser His Asn Thr Val Asn Glu Glu Leu Pro His Asn Cys Ile 
225                 230                 235                 240 


Glu Gln Pro Gln Gln Asn Asp Glu Ser Ser Ser Lys Val Arg Thr Ser 
                245                 250                 255     


Ser Asp Met Asn Arg Arg Lys Ser Ile Lys Asp His Leu Lys Asn Ala 
            260                 265                 270         


Met Thr Gly Asn Ala Lys Ala Gln Thr Pro Ile Phe Ser Arg Ser Lys 
        275                 280                 285             


Gln Leu Lys Asp Thr Leu Leu Ser Glu Glu Ile Asn Val Ala Lys Lys 
    290                 295                 300                 


Thr Val Glu Ser Ser Ser Asn Asp Leu Gly Pro Phe Tyr Ser Leu Pro 
305                 310                 315                 320 


Ser Lys Val Arg Asp Leu Tyr Ala Gln Phe Lys Gly Ile Glu Lys Leu 
                325                 330                 335     


Tyr Glu Trp Gln His Thr Cys Leu Thr Leu Asn Ser Val Gln Glu Arg 
            340                 345                 350         


Lys Asn Leu Ile Tyr Ser Leu Pro Thr Ser Gly Gly Lys Thr Leu Val 
        355                 360                 365             


Ala Glu Ile Leu Met Leu Gln Glu Leu Leu Cys Cys Arg Lys Asp Val 
    370                 375                 380                 


Leu Met Ile Leu Pro Tyr Val Ala Ile Val Gln Glu Lys Ile Ser Gly 
385                 390                 395                 400 


Leu Ser Ser Phe Gly Ile Glu Leu Gly Phe Phe Val Glu Glu Tyr Ala 
                405                 410                 415     


Gly Ser Lys Gly Arg Phe Pro Pro Thr Lys Arg Arg Glu Lys Lys Ser 
            420                 425                 430         


Leu Tyr Ile Ala Thr Ile Glu Lys Gly His Ser Leu Val Asn Ser Leu 
        435                 440                 445             


Ile Glu Thr Gly Arg Ile Asp Ser Leu Gly Leu Val Val Val Asp Glu 
    450                 455                 460                 


Leu His Met Ile Gly Glu Gly Ser Arg Gly Ala Thr Leu Glu Met Thr 
465                 470                 475                 480 


Leu Ala Lys Ile Leu Tyr Thr Ser Lys Thr Thr Gln Ile Ile Gly Met 
                485                 490                 495     


Ser Ala Thr Leu Asn Asn Val Glu Asp Leu Gln Lys Phe Leu Gln Ala 
            500                 505                 510         


Glu Tyr Tyr Thr Ser Gln Phe Arg Pro Val Glu Leu Lys Glu Tyr Leu 
        515                 520                 525             


Lys Ile Asn Asp Thr Ile Tyr Glu Val Asp Ser Lys Ala Glu Asn Gly 
    530                 535                 540                 


Met Thr Phe Ser Arg Leu Leu Asn Tyr Lys Tyr Ser Asp Thr Leu Lys 
545                 550                 555                 560 


Lys Met Asp Pro Asp His Leu Val Ala Leu Val Thr Glu Val Ile Pro 
                565                 570                 575     


Asn Tyr Ser Cys Leu Val Phe Cys Pro Ser Lys Lys Asn Cys Glu Asn 
            580                 585                 590         


Val Ala Glu Met Ile Cys Lys Phe Leu Ser Lys Glu Tyr Leu Lys His 
        595                 600                 605             


Lys Glu Lys Glu Lys Cys Glu Val Ile Lys Asn Leu Lys Asn Ile Gly 
    610                 615                 620                 


Asn Gly Asn Leu Cys Pro Val Leu Lys Arg Thr Ile Pro Phe Gly Val 
625                 630                 635                 640 


Ala Tyr His His Ser Gly Leu Thr Ser Asp Glu Arg Lys Leu Leu Glu 
                645                 650                 655     


Glu Ala Tyr Ser Thr Gly Val Leu Cys Leu Phe Thr Cys Thr Ser Thr 
            660                 665                 670         


Leu Ala Ala Gly Val Asn Leu Pro Ala Arg Arg Val Ile Leu Arg Ala 
        675                 680                 685             


Pro Tyr Val Ala Lys Glu Phe Leu Lys Arg Asn Gln Tyr Lys Gln Met 
    690                 695                 700                 


Ile Gly Arg Ala Gly Arg Ala Gly Ile Asp Thr Ile Gly Glu Ser Ile 
705                 710                 715                 720 


Leu Ile Leu Gln Glu Lys Asp Lys Gln Gln Val Leu Glu Leu Ile Thr 
                725                 730                 735     


Lys Pro Leu Glu Asn Cys Tyr Ser His Leu Val Gln Glu Phe Thr Lys 
            740                 745                 750         


Gly Ile Gln Thr Leu Phe Leu Ser Leu Ile Gly Leu Lys Ile Ala Thr 
        755                 760                 765             


Asn Leu Asp Asp Ile Tyr His Phe Met Asn Gly Thr Phe Phe Gly Val 
    770                 775                 780                 


Gln Gln Lys Val Leu Leu Lys Glu Lys Ser Leu Trp Glu Ile Thr Val 
785                 790                 795                 800 


Glu Ser Leu Arg Tyr Leu Thr Glu Lys Gly Leu Leu Gln Lys Asp Thr 
                805                 810                 815     


Ile Tyr Lys Ser Glu Glu Glu Val Gln Tyr Asn Phe His Ile Thr Lys 
            820                 825                 830         


Leu Gly Arg Ala Ser Phe Lys Gly Thr Ile Asp Leu Ala Tyr Cys Asp 
        835                 840                 845             


Ile Leu Tyr Arg Asp Leu Lys Lys Gly Leu Glu Gly Leu Val Leu Glu 
    850                 855                 860                 


Ser Leu Leu His Leu Ile Tyr Leu Thr Thr Pro Tyr Asp Leu Val Ser 
865                 870                 875                 880 


Gln Cys Asn Pro Asp Trp Met Ile Tyr Phe Arg Gln Phe Ser Gln Leu 
                885                 890                 895     


Ser Pro Ala Glu Gln Asn Val Ala Ala Ile Leu Gly Val Ser Glu Ser 
            900                 905                 910         


Phe Ile Gly Lys Lys Ala Ser Gly Gln Ala Ile Gly Lys Lys Val Asp 
        915                 920                 925             


Lys Asn Val Val Asn Arg Leu Tyr Leu Ser Phe Val Leu Tyr Thr Leu 
    930                 935                 940                 


Leu Lys Glu Thr Asn Ile Trp Thr Val Ser Glu Lys Phe Asn Met Pro 
945                 950                 955                 960 


Arg Gly Tyr Ile Gln Asn Leu Leu Thr Gly Thr Ala Ser Phe Ser Ser 
                965                 970                 975     


Cys Val Leu His Phe Cys Glu Glu Leu Glu Glu Phe Trp Val Tyr Arg 
            980                 985                 990         


Ala Leu Leu Val Glu Leu Thr Lys  Lys Leu Thr Tyr Cys  Val Lys Ala 
        995                 1000                 1005             


Glu Leu  Ile Pro Leu Met Glu  Val Thr Gly Val Leu  Glu Gly Arg 
    1010                 1015                 1020             


Ala Lys  Gln Leu Tyr Ser Ala  Gly Tyr Lys Ser Leu  Met His Leu 
    1025                 1030                 1035             


Ala Asn  Ala Asn Pro Glu Val  Leu Val Arg Thr Ile  Asp His Leu 
    1040                 1045                 1050             


Ser Arg  Arg Gln Ala Lys Gln  Ile Val Ser Ser Ala  Lys Met Leu 
    1055                 1060                 1065             


Leu His  Glu Lys Ala Glu Ala  Leu Gln Glu Glu Val  Glu Glu Leu 
    1070                 1075                 1080             


Leu Arg  Leu Pro Ser Asp Phe  Pro Gly Ala Val Ala  Ser Ser Thr 
    1085                 1090                 1095             


Asp Lys  Ala 
    1100     


<210>  4933
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HELT__Homo_sapiens__NP_001287710

<400>  4933

Met Ser Asp Lys Leu Lys Glu Arg Lys Arg Thr Pro Val Ser His Lys 
1               5                   10                  15      


Val Ile Glu Lys Arg Arg Arg Asp Arg Ile Asn Arg Cys Leu Asn Glu 
            20                  25                  30          


Leu Gly Lys Thr Val Pro Met Ala Leu Ala Lys Gln Ser Ser Gly Lys 
        35                  40                  45              


Leu Glu Lys Ala Glu Ile Leu Glu Met Thr Val Gln Tyr Leu Arg Ala 
    50                  55                  60                  


Leu His Ser Ala Asp Phe Pro Arg Gly Arg Glu Lys Ala Glu Leu Leu 
65                  70                  75                  80  


Ala Glu Phe Ala Asn Tyr Phe His Tyr Gly Tyr His Glu Cys Met Lys 
                85                  90                  95      


Asn Leu Val His Tyr Leu Thr Thr Val Glu Arg Met Glu Thr Lys Asp 
            100                 105                 110         


Thr Lys Tyr Ala Arg Ile Leu Ala Phe Leu Gln Ser Lys Ala Arg Leu 
        115                 120                 125             


Gly Ala Glu Pro Ala Phe Pro Pro Leu Gly Ser Leu Pro Glu Pro Asp 
    130                 135                 140                 


Phe Ser Tyr Gln Leu His Pro Ala Gly Pro Glu Phe Ala Gly His Ser 
145                 150                 155                 160 


Pro Gly Glu Ala Ala Val Phe Pro Gln Gly Ser Gly Ala Gly Pro Phe 
                165                 170                 175     


Pro Trp Pro Pro Gly Ala Ala Arg Ser Pro Ala Leu Pro Tyr Leu Pro 
            180                 185                 190         


Ser Ala Pro Val Pro Leu Ala Ser Pro Ala Gln Gln His Ser Pro Phe 
        195                 200                 205             


Leu Thr Pro Val Gln Gly Leu Asp Arg His Tyr Leu Asn Leu Ile Gly 
    210                 215                 220                 


His Ala His Pro Asn Ala Leu Asn Leu His Thr Pro Gln His Pro Pro 
225                 230                 235                 240 


Val Leu 
        


<210>  4934
<211>  2649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HELZ2__Homo_sapiens__NP_001032412

<400>  4934

Met Ala Val Trp Glu Ala Glu Gln Leu Gly Gly Leu Gln Arg Gly Asp 
1               5                   10                  15      


Leu Leu Thr Pro Pro Ala Pro Asp Gly Asp Gly Arg Thr Ala Pro Leu 
            20                  25                  30          


Gly Gln Pro Pro Gly Ala Gln Leu Tyr Cys Pro Ala Cys Leu Val Thr 
        35                  40                  45              


Cys His Ser Gln Glu Ala Phe Glu Asn His Cys Ala Ser Ser Glu His 
    50                  55                  60                  


Ala Gln Met Val Ala Phe Asp Gln Ala Leu Pro Trp Glu His Arg Ser 
65                  70                  75                  80  


Pro Pro Pro Gly Leu Ser Lys Phe Glu Leu Cys Pro Lys Pro Asp Leu 
                85                  90                  95      


Cys Glu Tyr Gly Asp Ala Cys Thr Lys Ala His Ser Ala Gln Glu Leu 
            100                 105                 110         


Gln Glu Trp Val Arg Arg Thr Gln Ala Val Glu Leu Arg Gly Gln Ala 
        115                 120                 125             


Ala Trp Gln Asp Gly Leu Val Pro Tyr Gln Glu Arg Leu Leu Ala Glu 
    130                 135                 140                 


Tyr Gln Arg Ser Ser Ser Glu Val Leu Val Leu Ala Glu Thr Leu Asp 
145                 150                 155                 160 


Gly Val Arg Val Thr Cys Asn Gln Pro Leu Met Tyr Gln Ala Gln Glu 
                165                 170                 175     


Arg Lys Thr Gln Tyr Ser Trp Thr Phe Ala Val His Ser Glu Glu Pro 
            180                 185                 190         


Leu Leu His Val Ala Leu Leu Lys Gln Glu Pro Gly Ala Asp Phe Ser 
        195                 200                 205             


Leu Val Ala Pro Gly Leu Pro Pro Gly Arg Leu Tyr Ala Arg Gly Glu 
    210                 215                 220                 


Arg Phe Arg Val Pro Ser Ser Thr Ala Asp Phe Gln Val Gly Val Arg 
225                 230                 235                 240 


Val Gln Ala Ala Ser Phe Gly Thr Phe Glu Gln Trp Val Val Phe Asp 
                245                 250                 255     


Phe Gly Arg Arg Pro Val Leu Leu Gln Lys Leu Gly Leu Gln Leu Gly 
            260                 265                 270         


Gln Gly Arg Arg Pro Gly Pro Cys Arg Asn Leu Ala Leu Gly His Pro 
        275                 280                 285             


Glu Glu Met Glu Arg Trp His Thr Gly Asn Arg His Val Val Pro Gly 
    290                 295                 300                 


Val Glu Arg Thr Ala Glu Gln Thr Ala Leu Met Ala Lys Tyr Lys Gly 
305                 310                 315                 320 


Pro Ala Leu Ala Leu Glu Phe Asn Arg Ser Ser Val Ala Ser Gly Pro 
                325                 330                 335     


Ile Ser Pro Thr Asn Tyr Arg Gln Arg Met His Gln Phe Leu Tyr Glu 
            340                 345                 350         


Glu Glu Ala Ala Gln Gln Gln Leu Val Ala Lys Leu Thr Leu Arg Gly 
        355                 360                 365             


Gln Val Phe Leu Lys Thr Ala Leu Gln Thr Pro Ala Leu Asn Met Leu 
    370                 375                 380                 


Phe Ala Pro Pro Gly Ala Leu Tyr Ala Glu Val Pro Val Pro Ser Ser 
385                 390                 395                 400 


Leu Met Pro Asp Thr Asp Gln Gly Phe Leu Leu Gly Arg Ala Val Ser 
                405                 410                 415     


Thr Ala Leu Val Ala Pro Val Pro Ala Pro Asp Asn Thr Val Phe Glu 
            420                 425                 430         


Val Arg Leu Glu Arg Arg Ala Ser Ser Glu Gln Ala Leu Trp Leu Leu 
        435                 440                 445             


Leu Pro Ala Arg Cys Cys Leu Ala Leu Gly Leu Gln Pro Glu Ala Arg 
    450                 455                 460                 


Leu Val Leu Glu Val Gln Phe Gln Ile Asp Pro Met Thr Phe Arg Leu 
465                 470                 475                 480 


Trp His Gln Ala Val Asp Thr Leu Pro Glu Glu Gln Leu Val Val Pro 
                485                 490                 495     


Asp Leu Pro Thr Cys Ala Leu Pro Arg Pro Trp Ser Val Pro Pro Leu 
            500                 505                 510         


Arg Arg Gly Asn Arg Lys Gln Glu Leu Ala Val Ala Leu Ile Ala Gly 
        515                 520                 525             


Trp Gly Pro Gly Asp Gly Arg Arg Val Pro Pro Leu Leu Ile Tyr Gly 
    530                 535                 540                 


Pro Phe Gly Thr Gly Lys Thr Tyr Thr Leu Ala Met Ala Ser Leu Glu 
545                 550                 555                 560 


Val Ile Arg Arg Pro Glu Thr Lys Val Leu Ile Cys Thr His Thr Asn 
                565                 570                 575     


Ser Ala Ala Asp Ile Tyr Ile Arg Glu Tyr Phe His Ser His Val Ser 
            580                 585                 590         


Gly Gly His Pro Glu Ala Thr Pro Leu Arg Val Met Tyr Thr Asp Arg 
        595                 600                 605             


Pro Leu Ser Gln Thr Asp Pro Val Thr Leu Gln Tyr Cys Cys Leu Thr 
    610                 615                 620                 


Asp Asp Arg Gln Ala Phe Arg Pro Pro Thr Arg Ala Glu Leu Ala Arg 
625                 630                 635                 640 


His Arg Val Val Val Thr Thr Thr Ser Gln Ala Arg Glu Leu Arg Val 
                645                 650                 655     


Pro Val Gly Phe Phe Ser His Ile Leu Ile Asp Glu Ala Ala Gln Met 
            660                 665                 670         


Leu Glu Cys Glu Ala Leu Thr Pro Leu Ala Tyr Ala Ser His Gly Thr 
        675                 680                 685             


Arg Leu Val Leu Ala Gly Asp His Met Gln Val Thr Pro Arg Leu Phe 
    690                 695                 700                 


Ser Val Ala Arg Ala Arg Ala Ala Glu His Thr Leu Leu His Arg Leu 
705                 710                 715                 720 


Phe Leu Cys Tyr Gln Gln Glu Thr His Glu Val Ala Arg Gln Ser Arg 
                725                 730                 735     


Leu Val Phe His Glu Asn Tyr Arg Cys Thr Asp Ala Ile Val Ser Phe 
            740                 745                 750         


Ile Ser Arg His Phe Tyr Val Ala Lys Gly Asn Pro Ile His Ala Arg 
        755                 760                 765             


Gly Lys Val Pro Pro His Pro Arg His Tyr Pro Leu Met Phe Cys His 
    770                 775                 780                 


Val Ala Gly Ser Pro Asp Arg Asp Met Ser Met Ala Ser Trp Leu Asn 
785                 790                 795                 800 


Leu Ala Glu Ile Ala Gln Val Val Glu Lys Val Gln Glu Ala Tyr Asn 
                805                 810                 815     


Thr Trp Pro Ser Cys Trp Gly Gly Arg Glu Gln Arg Cys Ile Cys Val 
            820                 825                 830         


Val Ser His Gly Ala Gln Val Ser Ala Leu Arg Gln Glu Leu Arg Arg 
        835                 840                 845             


Arg Asp Leu Gly Gln Val Ser Val Gly Ser Phe Glu Ile Leu Pro Gly 
    850                 855                 860                 


Arg Gln Phe Arg Val Val Val Leu Ser Thr Val His Thr Cys Gln Ser 
865                 870                 875                 880 


Leu Leu Ser Pro Gly Ala Leu Ala Pro Glu Phe Phe Thr Asp Ala Arg 
                885                 890                 895     


Val Leu Asn Thr Val Leu Thr Arg Ala Gln Ser Gln Leu Val Val Val 
            900                 905                 910         


Gly Asp Ala Val Ala Leu Cys Ser Phe Gly Ala Cys Gly Lys Leu Trp 
        915                 920                 925             


Glu Ser Phe Ile Arg Glu Cys Val Glu Arg His Ser Val Cys Pro Glu 
    930                 935                 940                 


Gly Leu Ser Met Glu Gln Val Glu Gln Gly Val Ala Gln Arg Arg Arg 
945                 950                 955                 960 


Trp Pro Pro Arg Gly Thr Gln Ala Gly Ala Ala Gly Asn Trp Glu Ala 
                965                 970                 975     


Ala Pro Glu Pro Val Gly Asp Leu Ala Glu Glu Gln Ala Ala Val Val 
            980                 985                 990         


Thr Ala Met Val Lys Ala Glu Pro  Gly Asp Glu Ala Leu  Ser Pro Ala 
        995                 1000                 1005             


Ser Arg  Asp Ile Thr Ala Thr  Thr Ala Gln Thr Glu  Ala Ala Ala 
    1010                 1015                 1020             


Ala Pro  Ala Gly Asp Ala Val  Lys Glu Asp Val Val  Pro Gly Ala 
    1025                 1030                 1035             


Cys Ala  Ala Gly Ala Ala Ala  Ala Ala Gly Val Glu  Ser Thr Glu 
    1040                 1045                 1050             


Ala Glu  Asp Ala Glu Ala Asp  Phe Trp Pro Trp Asp  Gly Glu Leu 
    1055                 1060                 1065             


Asn Ala  Asp Asp Ala Ile Leu  Arg Glu Leu Leu Asp  Glu Ser Gln 
    1070                 1075                 1080             


Lys Val  Met Val Thr Val Gly  Glu Asp Gly Leu Leu  Asp Thr Val 
    1085                 1090                 1095             


Ala Arg  Pro Glu Ser Leu Gln  Gln Ala Arg Leu Tyr  Glu Asn Leu 
    1100                 1105                 1110             


Pro Pro  Ala Ala Leu Arg Lys  Leu Leu His Ala Glu  Pro Glu Arg 
    1115                 1120                 1125             


Tyr Arg  His Cys Ser Phe Val  Pro Glu Thr Phe Glu  Arg Ala Ser 
    1130                 1135                 1140             


Ala Ile  Pro Leu Asp Asp Ala  Ser Ser Gly Pro Ile  Gln Val Arg 
    1145                 1150                 1155             


Gly Arg  Leu Asp Cys Gly Met  Ala Phe Ala Gly Asp  Glu Val Leu 
    1160                 1165                 1170             


Val Gln  Leu Leu Ser Gly Asp  Lys Ala Pro Glu Gly  Arg Leu Arg 
    1175                 1180                 1185             


Gly Arg  Val Leu Gly Val Leu  Lys Arg Lys Arg His  Glu Leu Ala 
    1190                 1195                 1200             


Phe Val  Cys Arg Met Asp Thr  Trp Asp Pro Arg Ile  Met Val Pro 
    1205                 1210                 1215             


Ile Asn  Gly Ser Val Thr Lys  Ile Phe Val Ala Glu  Leu Lys Asp 
    1220                 1225                 1230             


Pro Ser  Gln Val Pro Ile Tyr  Ser Leu Arg Lys Gly  Arg Leu Gln 
    1235                 1240                 1245             


Arg Val  Gly Leu Glu Arg Leu  Thr Ala Glu Ala Arg  His Ser Arg 
    1250                 1255                 1260             


Leu Phe  Trp Val Gln Ile Val  Leu Trp Arg Gln Gly  Phe Tyr Tyr 
    1265                 1270                 1275             


Pro Leu  Gly Ile Val Arg Glu  Val Leu Pro Glu Ala  Ser Thr Trp 
    1280                 1285                 1290             


Glu Gln  Gly Leu Arg Ile Leu  Gly Leu Glu Tyr Ser  Leu Arg Val 
    1295                 1300                 1305             


Pro Pro  Ser Asp Gln Ala Thr  Ile Thr Lys Val Leu  Gln Lys Tyr 
    1310                 1315                 1320             


His Thr  Glu Leu Gly Arg Val  Ala Gly Arg Arg Glu  Asp Cys Arg 
    1325                 1330                 1335             


Ala Phe  Leu Thr Phe Thr Val  Asp Pro Gln Gly Ala  Cys Asn Leu 
    1340                 1345                 1350             


Asp Asp  Ala Leu Ser Val Arg  Asp Leu Gly Pro Arg  Cys Glu Val 
    1355                 1360                 1365             


Ala Val  His Ile Thr Asp Val  Ala Ser Phe Val Pro  Arg Asp Gly 
    1370                 1375                 1380             


Val Leu  Asp Val Glu Ala Arg  Arg Gln Gly Ala Ala  Phe Tyr Ala 
    1385                 1390                 1395             


Pro Gly  Arg Glu Pro Val Pro  Met Leu Pro Ala Ser  Leu Cys Gln 
    1400                 1405                 1410             


Asp Val  Leu Ser Leu Leu Pro  Gly Arg Asp Arg Leu  Ala Ile Ser 
    1415                 1420                 1425             


Leu Phe  Leu Thr Met Glu Lys  Ala Ser Gly Gln Leu  Lys Ser Leu 
    1430                 1435                 1440             


Arg Phe  Ala Pro Ser Val Val  Gln Ser Asp Arg Gln  Leu Ser Tyr 
    1445                 1450                 1455             


Glu Glu  Ala Glu Glu Val Ile  Arg Gln His Pro Gly  Ala Gly Arg 
    1460                 1465                 1470             


Glu Leu  Pro Ala Arg Leu Asp  Ser Val Asp Ala Cys  Val Val Ala 
    1475                 1480                 1485             


Ala Cys  Tyr Phe Ser Arg Leu  Leu Arg Arg His Arg  Leu Arg Ser 
    1490                 1495                 1500             


Asp Cys  Phe Tyr Glu Gln Pro  Asp Glu Asp Gly Thr  Leu Gly Phe 
    1505                 1510                 1515             


Arg Ala  Ala His Ile Met Val  Lys Glu Tyr Met Ile  Gln Phe Asn 
    1520                 1525                 1530             


Arg Leu  Val Ala Glu Phe Leu  Val Gly Ser Glu Cys  Thr Arg Thr 
    1535                 1540                 1545             


Val Thr  Pro Leu Arg Trp Gln  Pro Ala Pro Arg Ser  Gln Gln Leu 
    1550                 1555                 1560             


Lys Ala  Leu Cys Glu Lys His  Gly Asp Arg Val Pro  Leu Ser Leu 
    1565                 1570                 1575             


His Leu  Gly His His Leu His  Gly Gly Gly Gly Ser  Pro Pro Asp 
    1580                 1585                 1590             


Thr Arg  Leu His Leu Leu Ala  Ser Leu Trp Lys Gln  Val Gln Phe 
    1595                 1600                 1605             


Ala Ala  Arg Thr Gln Asp Tyr  Glu Gln Met Val Asp  Leu Val Thr 
    1610                 1615                 1620             


Thr Asp  Asp Met His Pro Phe  Leu Ala Pro Ala Gly  Arg Asp Leu 
    1625                 1630                 1635             


Arg Lys  Ala Leu Glu Arg Ser  Ala Phe Gly Arg Cys  Ala Arg Gly 
    1640                 1645                 1650             


His Gln  Gln Gln Gly Gly His  Tyr Ser Leu Gln Val  Asp Trp Tyr 
    1655                 1660                 1665             


Thr Trp  Ala Thr Ser Pro Ile  Arg Arg Tyr Leu Asp  Val Val Leu 
    1670                 1675                 1680             


Gln Arg  Gln Ile Leu Leu Ala  Leu Gly His Gly Gly  Ser Ala Tyr 
    1685                 1690                 1695             


Ser Ala  Arg Asp Ile Asp Gly  Leu Cys Gln Ala Phe  Ser Leu Gln 
    1700                 1705                 1710             


His Ala  Leu Ala Gln Ser Tyr  Gln Arg Arg Ala Arg  Ser Leu His 
    1715                 1720                 1725             


Leu Ala  Val Gln Leu Lys Ala  Gln Pro Leu Asp Lys  Leu Gly Phe 
    1730                 1735                 1740             


Val Val  Asp Val Glu Ala Gly  Ser Arg Cys Phe Arg  Leu Leu Phe 
    1745                 1750                 1755             


Pro Ser  Asn Arg Glu Thr Leu  Pro Asp Pro Cys Pro  Val Pro Tyr 
    1760                 1765                 1770             


Gly Ser  Leu Gln Leu Ala Glu  His Pro His Ala Leu  Ala Gly Arg 
    1775                 1780                 1785             


Pro Gly  Leu Arg Leu Leu Trp  Arg Arg Arg Val Tyr  Ser Ala Gln 
    1790                 1795                 1800             


Gly Ser  Ser Pro Pro Leu Pro  Leu Pro Gly Thr Val  Pro Asp Pro 
    1805                 1810                 1815             


His Thr  Leu Ala Val Glu Thr  Ala Leu Trp Lys Gln  Leu Leu Glu 
    1820                 1825                 1830             


Leu Val  Glu Leu Gln Arg Trp  Pro Glu Ala Ala Ala  Leu Ile Gln 
    1835                 1840                 1845             


Glu Lys  Gly Glu Ala Ser Gln  Arg Arg Glu Leu Val  Gln Val Gln 
    1850                 1855                 1860             


Arg Ser  His Cys Gly His Phe  Leu Glu Val Ala Arg  Glu Leu Gly 
    1865                 1870                 1875             


Ser Gly  Asp Thr Leu Gln Val  Gln Leu Gly Thr Ser  Leu Gln His 
    1880                 1885                 1890             


Gly Phe  Leu Val Pro Ser Pro  Gln Leu Trp Thr Val  Ala Pro Gly 
    1895                 1900                 1905             


Phe Ser  Leu Cys Leu Glu His  Val Glu Arg Pro Gly  Asp Cys Phe 
    1910                 1915                 1920             


Ser Gly  Arg Val Tyr Arg Ala  Pro Arg Asp Arg Tyr  Arg Asp Val 
    1925                 1930                 1935             


Asp Glu  Tyr Ala Cys Val Trp  Glu Pro Phe Cys Ala  Leu Glu Ser 
    1940                 1945                 1950             


Ala Thr  Gly Ala Val Ala Glu  Asn Asp Ser Val Thr  Leu Gln His 
    1955                 1960                 1965             


Leu Ser  Val Ser Trp Glu Ala  Ser Arg Thr Pro Gln  Gly Gln Leu 
    1970                 1975                 1980             


Gln Gly  Ala Phe Arg Leu Glu  Ala Ala Phe Leu Glu  Glu Asn Cys 
    1985                 1990                 1995             


Ala Asp  Ile Asn Phe Ser Cys  Cys Tyr Leu Cys Ile  Arg Leu Glu 
    2000                 2005                 2010             


Gly Leu  Pro Ala Pro Thr Ala  Ser Pro Arg Pro Gly  Pro Ser Ser 
    2015                 2020                 2025             


Leu Gly  Pro Gly Leu Asn Val  Asp Pro Gly Thr Tyr  Thr Trp Val 
    2030                 2035                 2040             


Ala His  Gly Gln Thr Gln Asp  Trp Asp Gln Glu Arg  Arg Ala Asp 
    2045                 2050                 2055             


Arg Gln  Glu Ala Pro Arg Arg  Val His Leu Phe Val  His His Met 
    2060                 2065                 2070             


Gly Met  Glu Lys Val Pro Glu  Glu Val Leu Arg Pro  Gly Thr Leu 
    2075                 2080                 2085             


Phe Thr  Val Glu Leu Leu Pro  Lys Gln Leu Pro Asp  Leu Arg Lys 
    2090                 2095                 2100             


Glu Glu  Ala Val Arg Gly Leu  Glu Glu Ala Ser Pro  Leu Val Thr 
    2105                 2110                 2115             


Ser Ile  Ala Leu Gly Arg Pro  Val Pro Gln Pro Leu  Cys Arg Val 
    2120                 2125                 2130             


Ile Pro  Ser Arg Phe Leu Glu  Arg Gln Thr Tyr Asn  Ile Pro Gly 
    2135                 2140                 2145             


Gly Arg  His Lys Leu Asn Pro  Ser Gln Asn Val Ala  Val Arg Glu 
    2150                 2155                 2160             


Ala Leu  Glu Lys Pro Phe Thr  Val Ile Gln Gly Pro  Pro Gly Thr 
    2165                 2170                 2175             


Gly Lys  Thr Ile Val Gly Leu  His Ile Val Phe Trp  Phe His Lys 
    2180                 2185                 2190             


Ser Asn  Gln Glu Gln Val Gln  Pro Gly Gly Pro Pro  Arg Gly Glu 
    2195                 2200                 2205             


Lys Arg  Leu Gly Gly Pro Cys  Ile Leu Tyr Cys Gly  Pro Ser Asn 
    2210                 2215                 2220             


Lys Ser  Val Asp Val Leu Ala  Gly Leu Leu Leu Arg  Arg Met Glu 
    2225                 2230                 2235             


Leu Lys  Pro Leu Arg Val Tyr  Ser Glu Gln Ala Glu  Ala Ser Glu 
    2240                 2245                 2250             


Phe Pro  Val Pro Arg Val Gly  Ser Arg Lys Leu Leu  Arg Lys Ser 
    2255                 2260                 2265             


Pro Arg  Glu Gly Arg Pro Asn  Gln Ser Leu Arg Ser  Ile Thr Leu 
    2270                 2275                 2280             


His His  Arg Ile Arg Gln Ala  Pro Asn Pro Tyr Ser  Ser Glu Ile 
    2285                 2290                 2295             


Lys Ala  Phe Asp Thr Arg Leu  Gln Arg Gly Glu Leu  Phe Ser Arg 
    2300                 2305                 2310             


Glu Asp  Leu Val Trp Tyr Lys  Lys Val Leu Trp Glu  Ala Arg Lys 
    2315                 2320                 2325             


Phe Glu  Leu Asp Arg His Glu  Val Ile Leu Cys Thr  Cys Ser Cys 
    2330                 2335                 2340             


Ala Ala  Ser Ala Ser Leu Lys  Ile Leu Asp Val Arg  Gln Ile Leu 
    2345                 2350                 2355             


Val Asp  Glu Ala Gly Met Ala  Thr Glu Pro Glu Thr  Leu Ile Pro 
    2360                 2365                 2370             


Leu Val  Gln Phe Pro Gln Ala  Glu Lys Val Val Leu  Leu Gly Asp 
    2375                 2380                 2385             


His Lys  Gln Leu Arg Pro Val  Val Lys Asn Glu Arg  Leu Gln Asn 
    2390                 2395                 2400             


Leu Gly  Leu Asp Arg Ser Leu  Phe Glu Arg Tyr His  Glu Asp Ala 
    2405                 2410                 2415             


His Met  Leu Asp Thr Gln Tyr  Arg Met His Glu Gly  Ile Cys Ala 
    2420                 2425                 2430             


Phe Pro  Ser Val Ala Phe Tyr  Lys Ser Lys Leu Lys  Thr Trp Gln 
    2435                 2440                 2445             


Gly Leu  Arg Arg Pro Pro Ser  Val Leu Gly His Ala  Gly Lys Glu 
    2450                 2455                 2460             


Ser Cys  Pro Val Ile Phe Gly  His Val Gln Gly His  Glu Arg Ser 
    2465                 2470                 2475             


Leu Leu  Val Ser Thr Asp Glu  Gly Asn Glu Asn Ser  Lys Ala Asn 
    2480                 2485                 2490             


Leu Glu  Glu Val Ala Glu Val  Val Arg Ile Thr Lys  Gln Leu Thr 
    2495                 2500                 2505             


Leu Gly  Arg Thr Val Glu Pro  Gln Asp Ile Ala Val  Leu Thr Pro 
    2510                 2515                 2520             


Tyr Asn  Ala Gln Ala Ser Glu  Ile Ser Lys Ala Leu  Arg Arg Glu 
    2525                 2530                 2535             


Gly Ile  Ala Gly Val Ala Val  Ser Ser Ile Thr Lys  Ser Gln Gly 
    2540                 2545                 2550             


Ser Glu  Trp Arg Tyr Val Leu  Val Ser Thr Val Arg  Thr Cys Ala 
    2555                 2560                 2565             


Lys Ser  Asp Leu Asp Gln Arg  Pro Thr Lys Ser Trp  Leu Lys Lys 
    2570                 2575                 2580             


Phe Leu  Gly Phe Val Val Asp  Pro Asn Gln Val Asn  Val Ala Val 
    2585                 2590                 2595             


Thr Arg  Ala Gln Glu Gly Leu  Cys Leu Ile Gly Asp  His Leu Leu 
    2600                 2605                 2610             


Leu Arg  Cys Cys Pro Leu Trp  Arg Ser Leu Leu Asp  Phe Cys Glu 
    2615                 2620                 2625             


Ala Gln  Gln Thr Leu Val Pro  Ala Gly Gln Val Arg  Val Cys Arg 
    2630                 2635                 2640             


Arg Pro  Thr Met Pro Ser 
    2645                 


<210>  4935
<211>  1942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HELZ__Homo_sapiens__NP_055692

<400>  4935

Met Glu Asp Arg Arg Ala Glu Lys Ser Cys Glu Gln Ala Cys Glu Ser 
1               5                   10                  15      


Leu Lys Arg Gln Asp Tyr Glu Met Ala Leu Lys His Cys Thr Glu Ala 
            20                  25                  30          


Leu Leu Ser Leu Gly Gln Tyr Ser Met Ala Asp Phe Thr Gly Pro Cys 
        35                  40                  45              


Pro Leu Glu Ile Glu Arg Ile Lys Ile Glu Ser Leu Leu Tyr Arg Ile 
    50                  55                  60                  


Ala Ser Phe Leu Gln Leu Lys Asn Tyr Val Gln Ala Asp Glu Asp Cys 
65                  70                  75                  80  


Arg His Val Leu Gly Glu Gly Leu Ala Lys Gly Glu Asp Ala Phe Arg 
                85                  90                  95      


Ala Val Leu Cys Cys Met Gln Leu Lys Gly Lys Leu Gln Pro Val Ser 
            100                 105                 110         


Thr Ile Leu Ala Lys Ser Leu Thr Gly Glu Ser Leu Asn Gly Met Val 
        115                 120                 125             


Thr Lys Asp Leu Thr Arg Leu Lys Thr Leu Leu Ser Glu Thr Glu Thr 
    130                 135                 140                 


Ala Thr Ser Asn Ala Leu Ser Gly Tyr His Val Glu Asp Leu Asp Glu 
145                 150                 155                 160 


Gly Ser Cys Asn Gly Trp His Phe Arg Pro Pro Pro Arg Gly Ile Thr 
                165                 170                 175     


Ser Ser Glu Glu Tyr Thr Leu Cys Lys Arg Phe Leu Glu Gln Gly Ile 
            180                 185                 190         


Cys Arg Tyr Gly Ala Gln Cys Thr Ser Ala His Ser Gln Glu Glu Leu 
        195                 200                 205             


Ala Glu Trp Gln Lys Arg Tyr Ala Ser Arg Leu Ile Lys Leu Lys Gln 
    210                 215                 220                 


Gln Asn Glu Asn Lys Gln Leu Ser Gly Ser Tyr Met Glu Thr Leu Ile 
225                 230                 235                 240 


Glu Lys Trp Met Asn Ser Leu Ser Pro Glu Lys Val Leu Ser Glu Cys 
                245                 250                 255     


Ile Glu Gly Val Lys Val Glu His Asn Pro Asp Leu Ser Val Thr Val 
            260                 265                 270         


Ser Thr Lys Lys Ser His Gln Thr Trp Thr Phe Ala Leu Thr Cys Lys 
        275                 280                 285             


Pro Ala Arg Met Leu Tyr Arg Val Ala Leu Leu Tyr Asp Ala His Arg 
    290                 295                 300                 


Pro His Phe Ser Ile Ile Ala Ile Ser Ala Gly Asp Ser Thr Thr Gln 
305                 310                 315                 320 


Val Ser Gln Glu Val Pro Glu Asn Cys Gln Glu Trp Ile Gly Gly Lys 
                325                 330                 335     


Met Ala Gln Asn Gly Leu Asp His Tyr Val Tyr Lys Val Gly Ile Ala 
            340                 345                 350         


Phe Asn Thr Glu Ile Phe Gly Thr Phe Arg Gln Thr Ile Val Phe Asp 
        355                 360                 365             


Phe Gly Leu Glu Pro Val Leu Met Gln Arg Val Met Ile Asp Ala Ala 
    370                 375                 380                 


Ser Thr Glu Asp Leu Glu Tyr Leu Met His Ala Lys Gln Gln Leu Val 
385                 390                 395                 400 


Thr Thr Ala Lys Arg Trp Asp Ser Ser Ser Lys Thr Ile Ile Asp Phe 
                405                 410                 415     


Glu Pro Asn Glu Thr Thr Asp Leu Glu Lys Ser Leu Leu Ile Arg Tyr 
            420                 425                 430         


Gln Ile Pro Leu Ser Ala Asp Gln Leu Phe Thr Gln Ser Val Leu Asp 
        435                 440                 445             


Lys Ser Leu Thr Lys Ser Asn Tyr Gln Ser Arg Leu His Asp Leu Leu 
    450                 455                 460                 


Tyr Ile Glu Glu Ile Ala Gln Tyr Lys Glu Ile Ser Lys Phe Asn Leu 
465                 470                 475                 480 


Lys Val Gln Leu Gln Ile Leu Ala Ser Phe Met Leu Thr Gly Val Ser 
                485                 490                 495     


Gly Gly Ala Lys Tyr Ala Gln Asn Gly Gln Leu Phe Gly Arg Phe Lys 
            500                 505                 510         


Leu Thr Glu Thr Leu Ser Glu Asp Thr Leu Ala Gly Arg Leu Val Met 
        515                 520                 525             


Thr Lys Val Asn Ala Val Tyr Leu Leu Pro Val Pro Lys Gln Lys Leu 
    530                 535                 540                 


Val Gln Thr Gln Gly Thr Lys Glu Lys Val Tyr Glu Ala Thr Ile Glu 
545                 550                 555                 560 


Glu Lys Thr Lys Glu Tyr Ile Phe Leu Arg Leu Ser Arg Glu Cys Cys 
                565                 570                 575     


Glu Glu Leu Asn Leu Arg Pro Asp Cys Asp Thr Gln Val Glu Leu Gln 
            580                 585                 590         


Phe Gln Leu Asn Arg Leu Pro Leu Cys Glu Met His Tyr Ala Leu Asp 
        595                 600                 605             


Arg Ile Lys Asp Asn Gly Val Leu Phe Pro Asp Ile Ser Met Thr Pro 
    610                 615                 620                 


Thr Ile Pro Trp Ser Pro Asn Arg Gln Trp Asp Glu Gln Leu Asp Pro 
625                 630                 635                 640 


Arg Leu Asn Ala Lys Gln Lys Glu Ala Val Leu Ala Ile Thr Thr Pro 
                645                 650                 655     


Leu Ala Ile Gln Leu Pro Pro Val Leu Ile Ile Gly Pro Tyr Gly Thr 
            660                 665                 670         


Gly Lys Thr Phe Thr Leu Ala Gln Ala Val Lys His Ile Leu Gln Gln 
        675                 680                 685             


Gln Glu Thr Arg Ile Leu Ile Cys Thr His Ser Asn Ser Ala Ala Asp 
    690                 695                 700                 


Leu Tyr Ile Lys Asp Tyr Leu His Pro Tyr Val Glu Ala Gly Asn Pro 
705                 710                 715                 720 


Gln Ala Arg Pro Leu Arg Val Tyr Phe Arg Asn Arg Trp Val Lys Thr 
                725                 730                 735     


Val His Pro Val Val His Gln Tyr Cys Leu Ile Ser Ser Ala His Ser 
            740                 745                 750         


Thr Phe Gln Met Pro Gln Lys Glu Asp Ile Leu Lys His Arg Val Val 
        755                 760                 765             


Val Val Thr Leu Asn Thr Ser Gln Tyr Leu Cys Gln Leu Asp Leu Glu 
    770                 775                 780                 


Pro Gly Phe Phe Thr His Ile Leu Leu Asp Glu Ala Ala Gln Ala Met 
785                 790                 795                 800 


Glu Cys Glu Thr Ile Met Pro Leu Ala Leu Ala Thr Gln Asn Thr Arg 
                805                 810                 815     


Ile Val Leu Ala Gly Asp His Met Gln Leu Ser Pro Phe Val Tyr Ser 
            820                 825                 830         


Glu Phe Ala Arg Glu Arg Asn Leu His Val Ser Leu Leu Asp Arg Leu 
        835                 840                 845             


Tyr Glu His Tyr Pro Ala Glu Phe Pro Cys Arg Ile Leu Leu Cys Glu 
    850                 855                 860                 


Asn Tyr Arg Ser His Glu Ala Ile Ile Asn Tyr Thr Ser Glu Leu Phe 
865                 870                 875                 880 


Tyr Glu Gly Lys Leu Met Ala Ser Gly Lys Gln Pro Ala His Lys Asp 
                885                 890                 895     


Phe Tyr Pro Leu Thr Phe Phe Thr Ala Arg Gly Glu Asp Val Gln Glu 
            900                 905                 910         


Lys Asn Ser Thr Ala Phe Tyr Asn Asn Ala Glu Val Phe Glu Val Val 
        915                 920                 925             


Glu Arg Val Glu Glu Leu Arg Arg Lys Trp Pro Val Ala Trp Gly Lys 
    930                 935                 940                 


Leu Asp Asp Gly Ser Ile Gly Val Val Thr Pro Tyr Ala Asp Gln Val 
945                 950                 955                 960 


Phe Arg Ile Arg Ala Glu Leu Arg Lys Lys Arg Leu Ser Asp Val Asn 
                965                 970                 975     


Val Glu Arg Val Leu Asn Val Gln Gly Lys Gln Phe Arg Val Leu Phe 
            980                 985                 990         


Leu Ser Thr Val Arg Thr Arg His  Thr Cys Lys His Lys  Gln Thr Pro 
        995                 1000                 1005             


Ile Lys  Lys Lys Glu Gln Leu  Leu Glu Asp Ser Thr  Glu Asp Leu 
    1010                 1015                 1020             


Asp Tyr  Gly Phe Leu Ser Asn  Tyr Lys Leu Leu Asn  Thr Ala Ile 
    1025                 1030                 1035             


Thr Arg  Ala Gln Ser Leu Val  Ala Val Val Gly Asp  Pro Ile Ala 
    1040                 1045                 1050             


Leu Cys  Ser Ile Gly Arg Cys  Arg Lys Phe Trp Glu  Arg Phe Ile 
    1055                 1060                 1065             


Ala Leu  Cys His Glu Asn Ser  Ser Leu His Gly Ile  Thr Phe Glu 
    1070                 1075                 1080             


Gln Ile  Lys Ala Gln Leu Glu  Ala Leu Glu Leu Lys  Lys Thr Tyr 
    1085                 1090                 1095             


Val Leu  Asn Pro Leu Ala Pro  Glu Phe Ile Pro Arg  Ala Leu Arg 
    1100                 1105                 1110             


Leu Gln  His Ser Gly Ser Thr  Asn Lys Gln Gln Gln  Ser Pro Pro 
    1115                 1120                 1125             


Lys Gly  Lys Ser Leu His His  Thr Gln Asn Asp His  Phe Gln Asn 
    1130                 1135                 1140             


Asp Gly  Ile Val Gln Pro Asn  Pro Ser Val Leu Ile  Gly Asn Pro 
    1145                 1150                 1155             


Ile Arg  Ala Tyr Thr Pro Pro  Pro Pro Leu Gly Pro  His Pro Asn 
    1160                 1165                 1170             


Leu Gly  Lys Ser Pro Ser Pro  Val Gln Arg Ile Asp  Pro His Thr 
    1175                 1180                 1185             


Gly Thr  Ser Ile Leu Tyr Val  Pro Ala Val Tyr Gly  Gly Asn Val 
    1190                 1195                 1200             


Val Met  Ser Val Pro Leu Pro  Val Pro Trp Thr Gly  Tyr Gln Gly 
    1205                 1210                 1215             


Arg Phe  Ala Val Asp Pro Arg  Ile Ile Thr His Gln  Ala Ala Met 
    1220                 1225                 1230             


Ala Tyr  Asn Met Asn Leu Leu  Gln Thr His Gly Arg  Gly Ser Pro 
    1235                 1240                 1245             


Ile Pro  Tyr Gly Leu Gly His  His Pro Pro Val Thr  Ile Gly Gln 
    1250                 1255                 1260             


Pro Gln  Asn Gln His Gln Glu  Lys Asp Gln His Glu  Gln Asn Arg 
    1265                 1270                 1275             


Asn Gly  Lys Ser Asp Thr Asn  Asn Ser Gly Pro Glu  Ile Asn Lys 
    1280                 1285                 1290             


Ile Arg  Thr Pro Glu Lys Lys  Pro Thr Glu Pro Lys  Gln Val Asp 
    1295                 1300                 1305             


Leu Glu  Ser Asn Pro Gln Asn  Arg Ser Pro Glu Ser  Arg Pro Ser 
    1310                 1315                 1320             


Val Val  Tyr Pro Ser Thr Lys  Phe Pro Arg Lys Asp  Asn Leu Asn 
    1325                 1330                 1335             


Pro Arg  His Ile Asn Leu Pro  Leu Pro Ala Pro His  Ala Gln Tyr 
    1340                 1345                 1350             


Ala Ile  Pro Asn Arg His Phe  His Pro Leu Pro Gln  Leu Pro Arg 
    1355                 1360                 1365             


Pro Pro  Phe Pro Ile Pro Gln  Gln His Thr Leu Leu  Asn Gln Gln 
    1370                 1375                 1380             


Gln Asn  Asn Leu Pro Glu Gln  Pro Asn Gln Ile Pro  Pro Gln Pro 
    1385                 1390                 1395             


Asn Gln  Val Val Gln Gln Gln  Ser Gln Leu Asn Gln  Gln Pro Gln 
    1400                 1405                 1410             


Gln Pro  Pro Pro Gln Leu Ser  Pro Ala Tyr Gln Ala  Gly Pro Asn 
    1415                 1420                 1425             


Asn Ala  Phe Phe Asn Ser Ala  Val Ala His Arg Pro  Gln Ser Pro 
    1430                 1435                 1440             


Pro Ala  Glu Ala Val Ile Pro  Glu Gln Gln Pro Pro  Pro Met Leu 
    1445                 1450                 1455             


Gln Glu  Gly His Ser Pro Leu  Arg Ala Ile Ala Gln  Pro Gly Pro 
    1460                 1465                 1470             


Ile Leu  Pro Ser His Leu Asn  Ser Phe Ile Asp Glu  Asn Pro Ser 
    1475                 1480                 1485             


Gly Leu  Pro Ile Gly Glu Ala  Leu Asp Arg Ile His  Gly Ser Val 
    1490                 1495                 1500             


Ala Leu  Glu Thr Leu Arg Gln  Gln Gln Ala Arg Phe  Gln Gln Trp 
    1505                 1510                 1515             


Ser Glu  His His Ala Phe Leu  Ser Gln Gly Ser Val  Pro Tyr Pro 
    1520                 1525                 1530             


His His  His His Pro His Leu  Gln His Leu Pro Gln  Pro Pro Leu 
    1535                 1540                 1545             


Gly Leu  His Gln Pro Pro Val  Arg Ala Asp Trp Lys  Leu Thr Ser 
    1550                 1555                 1560             


Ser Ala  Glu Asp Glu Val Glu  Thr Thr Tyr Ser Arg  Phe Gln Asp 
    1565                 1570                 1575             


Leu Ile  Arg Glu Leu Ser His  Arg Asp Gln Ser Glu  Thr Arg Glu 
    1580                 1585                 1590             


Leu Ala  Glu Met Pro Pro Pro  Gln Ser Arg Leu Leu  Gln Tyr Arg 
    1595                 1600                 1605             


Gln Val  Gln Ser Arg Ser Pro  Pro Ala Val Pro Ser  Pro Pro Ser 
    1610                 1615                 1620             


Ser Thr  Asp His Ser Ser His  Phe Ser Asn Phe Asn  Asp Asn Ser 
    1625                 1630                 1635             


Arg Asp  Ile Glu Val Ala Ser  Asn Pro Ala Phe Pro  Gln Arg Leu 
    1640                 1645                 1650             


Pro Pro  Gln Ile Phe Asn Ser  Pro Phe Ser Leu Pro  Ser Glu His 
    1655                 1660                 1665             


Leu Ala  Pro Pro Pro Leu Lys  Tyr Leu Ala Pro Asp  Gly Ala Trp 
    1670                 1675                 1680             


Thr Phe  Ala Asn Leu Gln Gln  Asn His Leu Met Gly  Pro Gly Phe 
    1685                 1690                 1695             


Pro Tyr  Gly Leu Pro Pro Leu  Pro His Arg Pro Pro  Gln Asn Pro 
    1700                 1705                 1710             


Phe Val  Gln Ile Gln Asn His  Gln His Ala Ile Gly  Gln Glu Pro 
    1715                 1720                 1725             


Phe His  Pro Leu Ser Ser Arg  Thr Val Ser Ser Ser  Ser Leu Pro 
    1730                 1735                 1740             


Ser Leu  Glu Glu Tyr Glu Pro  Arg Gly Pro Gly Arg  Pro Leu Tyr 
    1745                 1750                 1755             


Gln Arg  Arg Ile Ser Ser Ser  Ser Val Gln Pro Cys  Ser Glu Glu 
    1760                 1765                 1770             


Val Ser  Thr Pro Gln Asp Ser  Leu Ala Gln Cys Lys  Glu Leu Gln 
    1775                 1780                 1785             


Asp His  Ser Asn Gln Ser Ser  Phe Asn Phe Ser Ser  Pro Glu Ser 
    1790                 1795                 1800             


Trp Val  Asn Thr Thr Ser Ser  Thr Pro Tyr Gln Asn  Ile Pro Cys 
    1805                 1810                 1815             


Asn Gly  Ser Ser Arg Thr Ala  Gln Pro Arg Glu Leu  Ile Ala Pro 
    1820                 1825                 1830             


Pro Lys  Thr Val Lys Pro Pro  Glu Asp Gln Leu Lys  Ser Glu Asn 
    1835                 1840                 1845             


Leu Glu  Val Ser Ser Ser Phe  Asn Tyr Ser Val Leu  Gln His Leu 
    1850                 1855                 1860             


Gly Gln  Phe Pro Pro Leu Met  Pro Asn Lys Gln Ile  Ala Glu Ser 
    1865                 1870                 1875             


Ala Asn  Ser Ser Ser Pro Gln  Ser Ser Ala Gly Gly  Lys Pro Ala 
    1880                 1885                 1890             


Met Ser  Tyr Ala Ser Ala Leu  Arg Ala Pro Pro Lys  Pro Arg Pro 
    1895                 1900                 1905             


Pro Pro  Glu Gln Ala Lys Lys  Ser Ser Asp Pro Leu  Ser Leu Phe 
    1910                 1915                 1920             


Gln Glu  Leu Ser Leu Gly Ser  Ser Ser Gly Ser Asn  Gly Phe Tyr 
    1925                 1930                 1935             


Ser Tyr  Phe Lys 
    1940         


<210>  4936
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEMGN__Homo_sapiens__XP_011517148

<400>  4936

Met Asp Leu Gly Lys Asp Gln Ser His Leu Lys His His Gln Thr Pro 
1               5                   10                  15      


Asp Pro His Gln Glu Glu Asn His Ser Pro Glu Val Ile Gly Thr Trp 
            20                  25                  30          


Ser Leu Arg Asn Arg Glu Leu Leu Arg Lys Arg Lys Ala Glu Val His 
        35                  40                  45              


Glu Lys Glu Thr Ser Gln Trp Leu Phe Gly Glu Gln Lys Lys Arg Lys 
    50                  55                  60                  


Gln Gln Arg Thr Gly Lys Gly Asn Arg Arg Gly Arg Lys Arg Gln Gln 
65                  70                  75                  80  


Asn Thr Glu Leu Lys Val Glu Pro Gln Pro Gln Ile Glu Lys Glu Ile 
                85                  90                  95      


Val Glu Lys Ala Leu Ala Pro Ile Glu Lys Lys Thr Glu Pro Pro Gly 
            100                 105                 110         


Ser Ile Thr Lys Val Phe Pro Ser Val Ala Ser Pro Gln Lys Val Val 
        115                 120                 125             


Pro Glu Glu His Phe Ser Glu Ile Cys Gln Glu Ser Asn Ile Tyr Gln 
    130                 135                 140                 


Glu Asn Phe Ser Glu Tyr Gln Glu Ile Ala Val Gln Asn His Ser Ser 
145                 150                 155                 160 


Glu Thr Cys Gln His Val Ser Glu Pro Glu Asp Leu Ser Pro Lys Met 
                165                 170                 175     


Tyr Gln Glu Ile Ser Val Leu Gln Asp Asn Ser Ser Lys Ile Cys Gln 
            180                 185                 190         


Asp Met Lys Glu Pro Glu Asp Asn Ser Pro Asn Thr Cys Gln Val Ile 
        195                 200                 205             


Ser Val Ile Gln Asp His Pro Phe Lys Met Tyr Gln Asp Met Ala Lys 
    210                 215                 220                 


Arg Glu Asp Leu Ala Pro Lys Met Cys Gln Glu Ala Ala Val Pro Lys 
225                 230                 235                 240 


Ile Leu Pro Cys Pro Thr Ser Glu Asp Thr Ala Asp Leu Ala Gly Cys 
                245                 250                 255     


Ser Leu Gln Ala Tyr Pro Lys Pro Asp Val Pro Lys Gly Tyr Ile Leu 
            260                 265                 270         


Asp Thr Asp Gln Asn Pro Ala Glu Pro Glu Glu Tyr Asn Glu Thr Asp 
        275                 280                 285             


Gln Gly Ile Ala Glu Thr Glu Gly Leu Phe Pro Lys Ile Gln Glu Ile 
    290                 295                 300                 


Ala Glu Pro Lys Asp Leu Ser Thr Lys Thr His Gln Glu Ser Ala Glu 
305                 310                 315                 320 


Pro Lys Tyr Leu Pro His Lys Thr Cys Asn Glu Ile Ile Val Pro Lys 
                325                 330                 335     


Ala Pro Ser His Lys Thr Ile Gln Glu Thr Pro His Ser Glu Asp Tyr 
            340                 345                 350         


Ser Ile Glu Ile Asn Gln Glu Thr Pro Gly Ser Glu Lys Tyr Ser Pro 
        355                 360                 365             


Glu Thr Tyr Gln Glu Ile Pro Gly Leu Glu Glu Tyr Ser Pro Glu Ile 
    370                 375                 380                 


Tyr Gln Glu Thr Ser Gln Leu Glu Glu Tyr Ser Pro Glu Ile Tyr Gln 
385                 390                 395                 400 


Glu Thr Pro Gly Pro Glu Asp Leu Ser Thr Glu Thr Tyr Lys Asn Lys 
                405                 410                 415     


Asp Val Pro Lys Glu Cys Phe Pro Glu Pro His Gln Glu Thr Gly Gly 
            420                 425                 430         


Pro Gln Gly Gln Asp Pro Lys Ala His Gln Glu Asp Ala Lys Asp Ala 
        435                 440                 445             


Tyr Thr Phe Pro Gln Glu Met Lys Glu Lys Pro Lys Glu Glu Pro Gly 
    450                 455                 460                 


Ile Pro Ala Ile Leu Asn Glu Ser His Pro Glu Asn Asp Val Tyr Ser 
465                 470                 475                 480 


Tyr Val Leu Phe 
                


<210>  4937
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEPACAM__Homo_sapiens__NP_689935

<400>  4937

Met Lys Arg Glu Arg Gly Ala Leu Ser Arg Ala Ser Arg Ala Leu Arg 
1               5                   10                  15      


Leu Ala Pro Phe Val Tyr Leu Leu Leu Ile Gln Thr Asp Pro Leu Glu 
            20                  25                  30          


Gly Val Asn Ile Thr Ser Pro Val Arg Leu Ile His Gly Thr Val Gly 
        35                  40                  45              


Lys Ser Ala Leu Leu Ser Val Gln Tyr Ser Ser Thr Ser Ser Asp Arg 
    50                  55                  60                  


Pro Val Val Lys Trp Gln Leu Lys Arg Asp Lys Pro Val Thr Val Val 
65                  70                  75                  80  


Gln Ser Ile Gly Thr Glu Val Ile Gly Thr Leu Arg Pro Asp Tyr Arg 
                85                  90                  95      


Asp Arg Ile Arg Leu Phe Glu Asn Gly Ser Leu Leu Leu Ser Asp Leu 
            100                 105                 110         


Gln Leu Ala Asp Glu Gly Thr Tyr Glu Val Glu Ile Ser Ile Thr Asp 
        115                 120                 125             


Asp Thr Phe Thr Gly Glu Lys Thr Ile Asn Leu Thr Val Asp Val Pro 
    130                 135                 140                 


Ile Ser Arg Pro Gln Val Leu Val Ala Ser Thr Thr Val Leu Glu Leu 
145                 150                 155                 160 


Ser Glu Ala Phe Thr Leu Asn Cys Ser His Glu Asn Gly Thr Lys Pro 
                165                 170                 175     


Ser Tyr Thr Trp Leu Lys Asp Gly Lys Pro Leu Leu Asn Asp Ser Arg 
            180                 185                 190         


Met Leu Leu Ser Pro Asp Gln Lys Val Leu Thr Ile Thr Arg Val Leu 
        195                 200                 205             


Met Glu Asp Asp Asp Leu Tyr Ser Cys Met Val Glu Asn Pro Ile Ser 
    210                 215                 220                 


Gln Gly Arg Ser Leu Pro Val Lys Ile Thr Val Tyr Arg Arg Ser Ser 
225                 230                 235                 240 


Leu Tyr Ile Ile Leu Ser Thr Gly Gly Ile Phe Leu Leu Val Thr Leu 
                245                 250                 255     


Val Thr Val Cys Ala Cys Trp Lys Pro Ser Lys Arg Lys Gln Lys Lys 
            260                 265                 270         


Leu Glu Lys Gln Asn Ser Leu Glu Tyr Met Asp Gln Asn Asp Asp Arg 
        275                 280                 285             


Leu Lys Pro Glu Ala Asp Thr Leu Pro Arg Ser Gly Glu Gln Glu Arg 
    290                 295                 300                 


Lys Asn Pro Met Ala Leu Tyr Ile Leu Lys Asp Lys Asp Ser Pro Glu 
305                 310                 315                 320 


Thr Glu Glu Asn Pro Ala Pro Glu Pro Arg Ser Ala Thr Glu Pro Gly 
                325                 330                 335     


Pro Pro Gly Tyr Ser Val Ser Pro Ala Val Pro Gly Arg Ser Pro Gly 
            340                 345                 350         


Leu Pro Ile Arg Ser Ala Arg Arg Tyr Pro Arg Ser Pro Ala Arg Ser 
        355                 360                 365             


Pro Ala Thr Gly Arg Thr His Ser Ser Pro Pro Arg Ala Pro Ser Ser 
    370                 375                 380                 


Pro Gly Arg Ser Arg Ser Ala Ser Arg Thr Leu Arg Thr Ala Gly Val 
385                 390                 395                 400 


His Ile Ile Arg Glu Gln Asp Glu Ala Gly Pro Val Glu Ile Ser Ala 
                405                 410                 415     


<210>  4938
<211>  1160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEPH__Homo_sapiens__NP_001124332

<400>  4938

Met Trp Ala Met Glu Ser Gly His Leu Leu Trp Ala Leu Leu Phe Met 
1               5                   10                  15      


Gln Ser Leu Trp Pro Gln Leu Thr Asp Gly Ala Thr Arg Val Tyr Tyr 
            20                  25                  30          


Leu Gly Ile Arg Asp Val Gln Trp Asn Tyr Ala Pro Lys Gly Arg Asn 
        35                  40                  45              


Val Ile Thr Asn Gln Pro Leu Asp Ser Asp Ile Val Ala Ser Ser Phe 
    50                  55                  60                  


Leu Lys Ser Asp Lys Asn Arg Ile Gly Gly Thr Tyr Lys Lys Thr Ile 
65                  70                  75                  80  


Tyr Lys Glu Tyr Lys Asp Asp Ser Tyr Thr Asp Glu Val Ala Gln Pro 
                85                  90                  95      


Ala Trp Leu Gly Phe Leu Gly Pro Val Leu Gln Ala Glu Val Gly Asp 
            100                 105                 110         


Val Ile Leu Ile His Leu Lys Asn Phe Ala Thr Arg Pro Tyr Thr Ile 
        115                 120                 125             


His Pro His Gly Val Phe Tyr Glu Lys Asp Ser Glu Gly Ser Leu Tyr 
    130                 135                 140                 


Pro Asp Gly Ser Ser Gly Pro Leu Lys Ala Asp Asp Ser Val Pro Pro 
145                 150                 155                 160 


Gly Gly Ser His Ile Tyr Asn Trp Thr Ile Pro Glu Gly His Ala Pro 
                165                 170                 175     


Thr Asp Ala Asp Pro Ala Cys Leu Thr Trp Ile Tyr His Ser His Val 
            180                 185                 190         


Asp Ala Pro Arg Asp Ile Ala Thr Gly Leu Ile Gly Pro Leu Ile Thr 
        195                 200                 205             


Cys Lys Arg Gly Ala Leu Asp Gly Asn Ser Pro Pro Gln Arg Gln Asp 
    210                 215                 220                 


Val Asp His Asp Phe Phe Leu Leu Phe Ser Val Val Asp Glu Asn Leu 
225                 230                 235                 240 


Ser Trp His Leu Asn Glu Asn Ile Ala Thr Tyr Cys Ser Asp Pro Ala 
                245                 250                 255     


Ser Val Asp Lys Glu Asp Glu Thr Phe Gln Glu Ser Asn Arg Met His 
            260                 265                 270         


Ala Ile Asn Gly Phe Val Phe Gly Asn Leu Pro Glu Leu Asn Met Cys 
        275                 280                 285             


Ala Gln Lys Arg Val Ala Trp His Leu Phe Gly Met Gly Asn Glu Ile 
    290                 295                 300                 


Asp Val His Thr Ala Phe Phe His Gly Gln Met Leu Thr Thr Arg Gly 
305                 310                 315                 320 


His His Thr Asp Val Ala Asn Ile Phe Pro Ala Thr Phe Val Thr Ala 
                325                 330                 335     


Glu Met Val Pro Trp Glu Pro Gly Thr Trp Leu Ile Ser Cys Gln Val 
            340                 345                 350         


Asn Ser His Phe Arg Asp Gly Met Gln Ala Leu Tyr Lys Val Lys Ser 
        355                 360                 365             


Cys Ser Met Ala Pro Pro Val Asp Leu Leu Thr Gly Lys Val Arg Gln 
    370                 375                 380                 


Tyr Phe Ile Glu Ala His Glu Ile Gln Trp Asp Tyr Gly Pro Met Gly 
385                 390                 395                 400 


His Asp Gly Ser Thr Gly Lys Asn Leu Arg Glu Pro Gly Ser Ile Ser 
                405                 410                 415     


Asp Lys Phe Phe Gln Lys Ser Ser Ser Arg Ile Gly Gly Thr Tyr Trp 
            420                 425                 430         


Lys Val Arg Tyr Glu Ala Phe Gln Asp Glu Thr Phe Gln Glu Lys Met 
        435                 440                 445             


His Leu Glu Glu Asp Arg His Leu Gly Ile Leu Gly Pro Val Ile Arg 
    450                 455                 460                 


Ala Glu Val Gly Asp Thr Ile Gln Val Val Phe Tyr Asn Arg Ala Ser 
465                 470                 475                 480 


Gln Pro Phe Ser Met Gln Pro His Gly Val Phe Tyr Glu Lys Asp Tyr 
                485                 490                 495     


Glu Gly Thr Val Tyr Asn Asp Gly Ser Ser Tyr Pro Gly Leu Val Ala 
            500                 505                 510         


Lys Pro Phe Glu Lys Val Thr Tyr Arg Trp Thr Val Pro Pro His Ala 
        515                 520                 525             


Gly Pro Thr Ala Gln Asp Pro Ala Cys Leu Thr Trp Met Tyr Phe Ser 
    530                 535                 540                 


Ala Ala Asp Pro Ile Arg Asp Thr Asn Ser Gly Leu Val Gly Pro Leu 
545                 550                 555                 560 


Leu Val Cys Arg Ala Gly Ala Leu Gly Ala Asp Gly Lys Gln Lys Gly 
                565                 570                 575     


Val Asp Lys Glu Phe Phe Leu Leu Phe Thr Val Leu Asp Glu Asn Lys 
            580                 585                 590         


Ser Trp Tyr Ser Asn Ala Asn Gln Ala Ala Ala Met Leu Asp Phe Arg 
        595                 600                 605             


Leu Leu Ser Glu Asp Ile Glu Gly Phe Gln Asp Ser Asn Arg Met His 
    610                 615                 620                 


Ala Ile Asn Gly Phe Leu Phe Ser Asn Leu Pro Arg Leu Asp Met Cys 
625                 630                 635                 640 


Lys Gly Asp Thr Val Ala Trp His Leu Leu Gly Leu Gly Thr Glu Thr 
                645                 650                 655     


Asp Val His Gly Val Met Phe Gln Gly Asn Thr Val Gln Leu Gln Gly 
            660                 665                 670         


Met Arg Lys Gly Ala Ala Met Leu Phe Pro His Thr Phe Val Met Ala 
        675                 680                 685             


Ile Met Gln Pro Asp Asn Leu Gly Thr Phe Glu Ile Tyr Cys Gln Ala 
    690                 695                 700                 


Gly Ser His Arg Glu Ala Gly Met Arg Ala Ile Tyr Asn Val Ser Gln 
705                 710                 715                 720 


Cys Pro Gly His Gln Ala Thr Pro Arg Gln Arg Tyr Gln Ala Ala Arg 
                725                 730                 735     


Ile Tyr Tyr Ile Met Ala Glu Glu Val Glu Trp Asp Tyr Cys Pro Asp 
            740                 745                 750         


Arg Ser Trp Glu Arg Glu Trp His Asn Gln Ser Glu Lys Asp Ser Tyr 
        755                 760                 765             


Gly Tyr Ile Phe Leu Ser Asn Lys Asp Gly Leu Leu Gly Ser Arg Tyr 
    770                 775                 780                 


Lys Lys Ala Val Phe Arg Glu Tyr Thr Asp Gly Thr Phe Arg Ile Pro 
785                 790                 795                 800 


Arg Pro Arg Thr Gly Pro Glu Glu His Leu Gly Ile Leu Gly Pro Leu 
                805                 810                 815     


Ile Lys Gly Glu Val Gly Asp Ile Leu Thr Val Val Phe Lys Asn Asn 
            820                 825                 830         


Ala Ser Arg Pro Tyr Ser Val His Ala His Gly Val Leu Glu Ser Thr 
        835                 840                 845             


Thr Val Trp Pro Leu Ala Ala Glu Pro Gly Glu Val Val Thr Tyr Gln 
    850                 855                 860                 


Trp Asn Ile Pro Glu Arg Ser Gly Pro Gly Pro Asn Asp Ser Ala Cys 
865                 870                 875                 880 


Val Ser Trp Ile Tyr Tyr Ser Ala Val Asp Pro Ile Lys Asp Met Tyr 
                885                 890                 895     


Ser Gly Leu Val Gly Pro Leu Ala Ile Cys Gln Lys Gly Ile Leu Glu 
            900                 905                 910         


Pro His Gly Gly Arg Ser Asp Met Asp Arg Glu Phe Ala Leu Leu Phe 
        915                 920                 925             


Leu Ile Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu Glu Asn Val Ala 
    930                 935                 940                 


Thr His Gly Ser Gln Asp Pro Gly Ser Ile Asn Leu Gln Asp Glu Thr 
945                 950                 955                 960 


Phe Leu Glu Ser Asn Lys Met His Ala Ile Asn Gly Lys Leu Tyr Ala 
                965                 970                 975     


Asn Leu Arg Gly Leu Thr Met Tyr Gln Gly Glu Arg Val Ala Trp Tyr 
            980                 985                 990         


Met Leu Ala Met Gly Gln Asp Val  Asp Leu His Thr Ile  His Phe His 
        995                 1000                 1005             


Ala Glu  Ser Phe Leu Tyr Arg  Asn Gly Glu Asn Tyr  Arg Ala Asp 
    1010                 1015                 1020             


Val Val  Asp Leu Phe Pro Gly  Thr Phe Glu Val Val  Glu Met Val 
    1025                 1030                 1035             


Ala Ser  Asn Pro Gly Thr Trp  Leu Met His Cys His  Val Thr Asp 
    1040                 1045                 1050             


His Val  His Ala Gly Met Glu  Thr Leu Phe Thr Val  Phe Ser Arg 
    1055                 1060                 1065             


Thr Glu  His Leu Ser Pro Leu  Thr Val Ile Thr Lys  Glu Thr Glu 
    1070                 1075                 1080             


Lys Val  Pro Pro Arg Asp Ile  Glu Glu Gly Asn Val  Lys Met Leu 
    1085                 1090                 1095             


Gly Met  Gln Ile Pro Ile Lys  Asn Val Glu Met Leu  Ala Ser Val 
    1100                 1105                 1110             


Leu Val  Ala Ile Ser Val Thr  Leu Leu Leu Val Val  Leu Ala Leu 
    1115                 1120                 1125             


Gly Gly  Val Val Trp Tyr Gln  His Arg Gln Arg Lys  Leu Arg Arg 
    1130                 1135                 1140             


Asn Arg  Arg Ser Ile Leu Asp  Asp Ser Phe Lys Leu  Leu Ser Phe 
    1145                 1150                 1155             


Lys Gln  
    1160 


<210>  4939
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEPN1__Homo_sapiens__NP_001032647

<400>  4939

Met Gly Asn Trp Gly Leu Gly Ile Ala Pro Trp Val Asp Gly Glu Ser 
1               5                   10                  15      


Glu Leu Glu Phe Arg Arg Leu Gly Met Gln Gly Pro Leu Glu Ala Leu 
            20                  25                  30          


Arg Arg Arg Glu Trp Asn Thr Gln Arg Ala Ser Phe Ser Phe Ser Phe 
        35                  40                  45              


Leu Ile Ala Leu Ser Pro His Thr Val Asp Tyr Cys His Ser Tyr Glu 
    50                  55                  60                  


Leu Phe Asn Arg Arg Trp His Gly His Val Leu Ala Thr Gln Arg Pro 
65                  70                  75                  80  


Ser Leu Phe Ile Leu Met Leu Val 
                85              


<210>  4940
<211>  4861
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HERC1__Homo_sapiens__NP_003913

<400>  4940

Met Ala Thr Met Ile Pro Pro Val Lys Leu Lys Trp Leu Glu His Leu 
1               5                   10                  15      


Asn Ser Ser Trp Ile Thr Glu Asp Ser Glu Ser Ile Ala Thr Arg Glu 
            20                  25                  30          


Gly Val Ala Val Leu Tyr Ser Lys Leu Val Ser Asn Lys Glu Val Val 
        35                  40                  45              


Pro Leu Pro Gln Gln Val Leu Cys Leu Lys Gly Pro Gln Leu Pro Asp 
    50                  55                  60                  


Phe Glu Arg Glu Ser Leu Ser Ser Asp Glu Gln Asp His Tyr Leu Asp 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Gln Leu Ala Leu Ala Lys Met Val Cys Ser Asp 
                85                  90                  95      


Ser Pro Phe Ala Gly Ala Leu Arg Lys Arg Leu Leu Val Leu Gln Arg 
            100                 105                 110         


Val Phe Tyr Ala Leu Ser Asn Lys Tyr His Asp Lys Gly Lys Val Lys 
        115                 120                 125             


Gln Gln Gln His Ser Pro Glu Ser Ser Ser Gly Ser Ala Asp Val His 
    130                 135                 140                 


Ser Val Ser Glu Arg Pro Arg Ser Ser Thr Asp Ala Leu Ile Glu Met 
145                 150                 155                 160 


Gly Val Arg Thr Gly Leu Ser Leu Leu Phe Ala Leu Leu Arg Gln Ser 
                165                 170                 175     


Trp Met Met Pro Val Ser Gly Pro Gly Leu Ser Leu Cys Asn Asp Val 
            180                 185                 190         


Ile His Thr Ala Ile Glu Val Val Ser Ser Leu Pro Pro Leu Ser Leu 
        195                 200                 205             


Ala Asn Glu Ser Lys Ile Pro Pro Met Gly Leu Asp Cys Leu Ser Gln 
    210                 215                 220                 


Val Thr Thr Phe Leu Lys Gly Val Thr Ile Pro Asn Ser Gly Ala Asp 
225                 230                 235                 240 


Thr Leu Gly Arg Arg Leu Ala Ser Glu Leu Leu Leu Gly Leu Ala Ala 
                245                 250                 255     


Gln Arg Gly Ser Leu Arg Tyr Leu Leu Glu Trp Ile Glu Met Ala Leu 
            260                 265                 270         


Gly Ala Ser Ala Val Val His Thr Met Glu Lys Gly Lys Leu Leu Ser 
        275                 280                 285             


Ser Gln Glu Gly Met Ile Ser Phe Asp Cys Phe Met Thr Ile Leu Met 
    290                 295                 300                 


Gln Met Arg Arg Ser Leu Gly Ser Ser Ala Asp Arg Ser Gln Trp Arg 
305                 310                 315                 320 


Glu Pro Thr Arg Thr Ser Asp Gly Leu Cys Ser Leu Tyr Glu Ala Ala 
                325                 330                 335     


Leu Cys Leu Phe Glu Glu Val Cys Arg Met Ala Ser Asp Tyr Ser Arg 
            340                 345                 350         


Thr Cys Ala Ser Pro Asp Ser Ile Gln Thr Gly Asp Ala Pro Ile Val 
        355                 360                 365             


Ser Glu Thr Cys Glu Val Tyr Val Trp Gly Ser Asn Ser Ser His Gln 
    370                 375                 380                 


Leu Val Glu Gly Thr Gln Glu Lys Ile Leu Gln Pro Lys Leu Ala Pro 
385                 390                 395                 400 


Ser Phe Ser Asp Ala Gln Thr Ile Glu Ala Gly Gln Tyr Cys Thr Phe 
                405                 410                 415     


Val Ile Ser Thr Asp Gly Ser Val Arg Ala Cys Gly Lys Gly Ser Tyr 
            420                 425                 430         


Gly Arg Leu Gly Leu Gly Asp Ser Asn Asn Gln Ser Thr Leu Lys Lys 
        435                 440                 445             


Leu Thr Phe Glu Pro His Arg Ser Ile Lys Lys Val Ser Ser Ser Lys 
    450                 455                 460                 


Gly Ser Asp Gly His Thr Leu Ala Phe Thr Thr Glu Gly Glu Val Phe 
465                 470                 475                 480 


Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly His Gly Asn Ser Ser 
                485                 490                 495     


Thr Gln Lys Tyr Pro Lys Leu Ile Gln Gly Pro Leu Gln Gly Lys Val 
            500                 505                 510         


Val Val Cys Val Ser Ala Gly Tyr Arg His Ser Ala Ala Val Thr Glu 
        515                 520                 525             


Asp Gly Glu Leu Tyr Thr Trp Gly Glu Gly Asp Phe Gly Arg Leu Gly 
    530                 535                 540                 


His Gly Asp Ser Asn Ser Arg Asn Ile Pro Thr Leu Val Lys Asp Ile 
545                 550                 555                 560 


Ser Asn Val Gly Glu Val Ser Cys Gly Ser Ser His Thr Ile Ala Leu 
                565                 570                 575     


Ser Lys Asp Gly Arg Thr Val Trp Ser Phe Gly Gly Gly Asp Asn Gly 
            580                 585                 590         


Lys Leu Gly His Gly Asp Thr Asn Arg Val Tyr Lys Pro Lys Val Ile 
        595                 600                 605             


Glu Ala Leu Gln Gly Met Phe Ile Arg Lys Val Cys Ala Gly Ser Gln 
    610                 615                 620                 


Ser Ser Leu Ala Leu Thr Ser Thr Gly Gln Val Tyr Ala Trp Gly Cys 
625                 630                 635                 640 


Gly Ala Cys Leu Gly Cys Gly Ser Ser Glu Ala Thr Ala Leu Arg Pro 
                645                 650                 655     


Lys Leu Ile Glu Glu Leu Ala Ala Thr Arg Ile Val Asp Val Ser Ile 
            660                 665                 670         


Gly Asp Ser His Cys Leu Ala Leu Ser His Asp Asn Glu Val Tyr Ala 
        675                 680                 685             


Trp Gly Asn Asn Ser Met Gly Gln Cys Gly Gln Gly Asn Ser Thr Gly 
    690                 695                 700                 


Pro Ile Thr Lys Pro Lys Lys Val Ser Gly Leu Asp Gly Ile Ala Ile 
705                 710                 715                 720 


Gln Gln Ile Ser Ala Gly Thr Ser His Ser Leu Ala Trp Thr Ala Leu 
                725                 730                 735     


Pro Arg Asp Arg Gln Val Val Ala Trp His Arg Pro Tyr Cys Val Asp 
            740                 745                 750         


Leu Glu Glu Ser Thr Phe Ser His Leu Arg Ser Phe Leu Glu Arg Tyr 
        755                 760                 765             


Cys Asp Lys Ile Asn Ser Glu Ile Pro Pro Leu Pro Phe Pro Ser Ser 
    770                 775                 780                 


Arg Glu His His Ser Phe Leu Lys Leu Cys Leu Lys Leu Leu Ser Asn 
785                 790                 795                 800 


His Leu Ala Leu Ala Leu Ala Gly Gly Val Ala Thr Ser Ile Leu Gly 
                805                 810                 815     


Arg Gln Ala Gly Pro Leu Arg Asn Leu Leu Phe Arg Leu Met Asp Ser 
            820                 825                 830         


Thr Val Pro Asp Glu Ile Gln Glu Val Val Ile Glu Thr Leu Ser Val 
        835                 840                 845             


Gly Ala Thr Met Leu Leu Pro Pro Leu Arg Glu Arg Met Glu Leu Leu 
    850                 855                 860                 


His Ser Leu Leu Pro Gln Gly Pro Asp Arg Trp Glu Ser Leu Ser Lys 
865                 870                 875                 880 


Gly Gln Arg Met Gln Leu Asp Ile Ile Leu Thr Ser Leu Gln Asp His 
                885                 890                 895     


Thr His Val Ala Ser Leu Leu Gly Tyr Ser Ser Pro Ser Asp Ala Ala 
            900                 905                 910         


Asp Leu Ser Ser Val Cys Thr Gly Tyr Gly Asn Leu Ser Asp Gln Pro 
        915                 920                 925             


Tyr Gly Thr Gln Ser Cys His Pro Asp Thr His Leu Ala Glu Ile Leu 
    930                 935                 940                 


Met Lys Thr Leu Leu Arg Asn Leu Gly Phe Tyr Thr Asp Gln Ala Phe 
945                 950                 955                 960 


Gly Glu Leu Glu Lys Asn Ser Asp Lys Phe Leu Leu Gly Thr Ser Ser 
                965                 970                 975     


Ser Glu Asn Ser Gln Pro Ala His Leu His Glu Leu Leu Cys Ser Leu 
            980                 985                 990         


Gln Lys Gln Leu Leu Ala Phe Cys  His Ile Asn Asn Ile  Ser Glu Asn 
        995                 1000                 1005             


Ser Ser  Ser Val Ala Leu Leu  His Lys His Leu Gln  Leu Leu Leu 
    1010                 1015                 1020             


Pro His  Ala Thr Asp Ile Tyr  Ser Arg Ser Ala Asn  Leu Leu Lys 
    1025                 1030                 1035             


Glu Ser  Pro Trp Asn Gly Ser  Val Gly Glu Lys Leu  Arg Asp Val 
    1040                 1045                 1050             


Ile Tyr  Val Ser Ala Ala Gly  Ser Met Leu Cys Gln  Ile Val Asn 
    1055                 1060                 1065             


Ser Leu  Leu Leu Leu Pro Val  Ser Val Ala Arg Pro  Leu Leu Ser 
    1070                 1075                 1080             


Tyr Leu  Leu Asp Leu Leu Pro  Pro Leu Asp Cys Leu  Asn Arg Leu 
    1085                 1090                 1095             


Leu Pro  Ala Ala Asp Leu Leu  Glu Asp Gln Glu Leu  Gln Trp Pro 
    1100                 1105                 1110             


Leu His  Gly Gly Pro Glu Leu  Ile Asp Pro Ala Gly  Leu Pro Leu 
    1115                 1120                 1125             


Pro Gln  Pro Ala Gln Ser Trp  Val Trp Leu Val Asp  Leu Glu Arg 
    1130                 1135                 1140             


Thr Ile  Ala Leu Leu Ile Gly  Arg Cys Leu Gly Gly  Met Leu Gln 
    1145                 1150                 1155             


Gly Ser  Pro Val Ser Pro Glu  Glu Gln Asp Thr Ala  Tyr Trp Met 
    1160                 1165                 1170             


Lys Thr  Pro Leu Phe Ser Asp  Gly Val Glu Met Asp  Thr Pro Gln 
    1175                 1180                 1185             


Leu Asp  Lys Cys Met Ser Cys  Leu Leu Glu Val Ala  Leu Ser Gly 
    1190                 1195                 1200             


Asn Glu  Glu Gln Lys Pro Phe  Asp Tyr Lys Leu Arg  Pro Glu Ile 
    1205                 1210                 1215             


Ala Val  Tyr Val Asp Leu Ala  Leu Gly Cys Ser Lys  Glu Pro Ala 
    1220                 1225                 1230             


Arg Ser  Leu Trp Ile Ser Met  Gln Asp Tyr Ala Val  Ser Lys Asp 
    1235                 1240                 1245             


Trp Asp  Ser Ala Thr Leu Ser  Asn Glu Ser Leu Leu  Asp Thr Val 
    1250                 1255                 1260             


Ser Arg  Phe Val Leu Ala Ala  Leu Leu Lys His Thr  Asn Leu Leu 
    1265                 1270                 1275             


Ser Gln  Ala Cys Gly Glu Ser  Arg Tyr Gln Pro Gly  Lys His Leu 
    1280                 1285                 1290             


Ser Glu  Val Tyr Arg Cys Val  Tyr Lys Val Arg Ser  Arg Leu Leu 
    1295                 1300                 1305             


Ala Cys  Lys Asn Leu Glu Leu  Ile Gln Thr Arg Ser  Ser Ser Arg 
    1310                 1315                 1320             


Asp Arg  Trp Ile Ser Glu Asn  Gln Asp Ser Ala Asp  Val Asp Pro 
    1325                 1330                 1335             


Gln Glu  His Ser Phe Thr Arg  Thr Ile Asp Glu Glu  Ala Glu Met 
    1340                 1345                 1350             


Glu Glu  Gln Ala Glu Arg Asp  Arg Glu Glu Gly His  Pro Glu Pro 
    1355                 1360                 1365             


Glu Asp  Glu Glu Glu Glu Arg  Glu His Glu Val Met  Thr Ala Gly 
    1370                 1375                 1380             


Lys Ile  Phe Gln Cys Phe Leu  Ser Ala Arg Glu Val  Ala Arg Ser 
    1385                 1390                 1395             


Arg Asp  Arg Asp Arg Met Asn  Ser Gly Ala Gly Ser  Gly Ala Arg 
    1400                 1405                 1410             


Ala Asp  Asp Pro Pro Pro Gln  Ser Gln Gln Glu Arg  Arg Val Ser 
    1415                 1420                 1425             


Thr Asp  Leu Pro Glu Gly Gln  Asp Val Tyr Thr Ala  Ala Cys Asn 
    1430                 1435                 1440             


Ser Val  Ile His Arg Cys Ala  Leu Leu Ile Leu Gly  Val Ser Pro 
    1445                 1450                 1455             


Val Ile  Asp Glu Leu Gln Lys  Arg Arg Glu Glu Gly  Gln Leu Gln 
    1460                 1465                 1470             


Gln Pro  Ser Thr Ser Ala Ser  Glu Gly Gly Gly Leu  Met Thr Arg 
    1475                 1480                 1485             


Ser Glu  Ser Leu Thr Ala Glu  Ser Arg Leu Val His  Thr Ser Pro 
    1490                 1495                 1500             


Asn Tyr  Arg Leu Ile Lys Ser  Arg Ser Glu Ser Asp  Leu Ser Gln 
    1505                 1510                 1515             


Pro Glu  Ser Asp Glu Glu Gly  Tyr Ala Leu Ser Gly  Arg Arg Asn 
    1520                 1525                 1530             


Val Asp  Leu Asp Leu Ala Ala  Ser His Arg Lys Arg  Gly Pro Met 
    1535                 1540                 1545             


His Ser  Gln Leu Glu Ser Leu  Ser Asp Ser Trp Ala  Arg Leu Lys 
    1550                 1555                 1560             


His Ser  Arg Asp Trp Leu Cys  Asn Ser Ser Tyr Ser  Phe Glu Ser 
    1565                 1570                 1575             


Asp Phe  Asp Leu Thr Lys Ser  Leu Gly Val His Thr  Leu Ile Glu 
    1580                 1585                 1590             


Asn Val  Val Ser Phe Val Ser  Gly Asp Val Gly Asn  Ala Pro Gly 
    1595                 1600                 1605             


Phe Lys  Glu Pro Glu Glu Ser  Met Ser Thr Ser Pro  Gln Ala Ser 
    1610                 1615                 1620             


Ile Ile  Ala Met Glu Gln Gln  Gln Leu Arg Ala Glu  Leu Arg Leu 
    1625                 1630                 1635             


Glu Ala  Leu His Gln Ile Leu  Val Leu Leu Ser Gly  Met Glu Glu 
    1640                 1645                 1650             


Lys Gly  Ser Ile Ser Leu Ala  Gly Ser Arg Leu Ser  Ser Gly Phe 
    1655                 1660                 1665             


Gln Ser  Ser Thr Leu Leu Thr  Ser Val Arg Leu Gln  Phe Leu Ala 
    1670                 1675                 1680             


Gly Cys  Phe Gly Leu Gly Thr  Val Gly His Thr Gly  Gly Lys Gly 
    1685                 1690                 1695             


Glu Ser  Gly Arg Leu His His  Tyr Gln Asp Gly Ile  Arg Ala Ala 
    1700                 1705                 1710             


Lys Arg  Asn Ile Gln Ile Glu  Ile Gln Val Ala Val  His Lys Ile 
    1715                 1720                 1725             


Tyr Gln  Gln Leu Ser Ala Thr  Leu Glu Arg Ala Leu  Gln Ala Asn 
    1730                 1735                 1740             


Lys His  His Ile Glu Ala Gln  Gln Arg Leu Leu Leu  Val Thr Val 
    1745                 1750                 1755             


Phe Ala  Leu Ser Val His Tyr  Gln Pro Val Asp Val  Ser Leu Ala 
    1760                 1765                 1770             


Ile Ser  Thr Gly Leu Leu Asn  Val Leu Ser Gln Leu  Cys Gly Thr 
    1775                 1780                 1785             


Asp Thr  Met Leu Gly Gln Pro  Leu Gln Leu Leu Pro  Lys Thr Gly 
    1790                 1795                 1800             


Val Ser  Gln Leu Ser Thr Ala  Leu Lys Val Ala Ser  Thr Arg Leu 
    1805                 1810                 1815             


Leu Gln  Ile Leu Ala Ile Thr  Thr Gly Thr Tyr Ala  Asp Lys Leu 
    1820                 1825                 1830             


Ser Pro  Lys Val Val Gln Ser  Leu Leu Asp Leu Leu  Cys Ser Gln 
    1835                 1840                 1845             


Leu Lys  Asn Leu Leu Ser Gln  Thr Gly Val Leu His  Met Ala Ser 
    1850                 1855                 1860             


Phe Gly  Glu Gly Glu Gln Glu  Asp Gly Glu Glu Glu  Glu Lys Lys 
    1865                 1870                 1875             


Val Asp  Ser Ser Gly Glu Thr  Glu Lys Lys Asp Phe  Arg Ala Ala 
    1880                 1885                 1890             


Leu Arg  Lys Gln His Ala Ala  Glu Leu His Leu Gly  Asp Phe Leu 
    1895                 1900                 1905             


Val Phe  Leu Arg Arg Val Val  Ser Ser Lys Ala Ile  Gln Ser Lys 
    1910                 1915                 1920             


Met Ala  Ser Pro Lys Trp Thr  Glu Val Leu Leu Asn  Ile Ala Ser 
    1925                 1930                 1935             


Gln Lys  Cys Ser Ser Gly Ile  Pro Leu Val Gly Asn  Leu Arg Thr 
    1940                 1945                 1950             


Arg Leu  Leu Ala Leu His Val  Leu Glu Ala Val Leu  Pro Ala Cys 
    1955                 1960                 1965             


Glu Ser  Gly Val Glu Asp Asp  Gln Met Ala Gln Ile  Val Glu Arg 
    1970                 1975                 1980             


Leu Phe  Ser Leu Leu Ser Asp  Cys Met Trp Glu Thr  Pro Ile Ala 
    1985                 1990                 1995             


Gln Ala  Lys His Ala Ile Gln  Ile Lys Glu Lys Glu  Gln Glu Ile 
    2000                 2005                 2010             


Lys Leu  Gln Lys Gln Gly Glu  Leu Glu Glu Glu Asp  Glu Asn Leu 
    2015                 2020                 2025             


Pro Ile  Gln Glu Val Ser Phe  Asp Pro Glu Lys Ala  Gln Cys Cys 
    2030                 2035                 2040             


Leu Val  Glu Asn Gly Gln Ile  Leu Thr His Gly Ser  Gly Gly Lys 
    2045                 2050                 2055             


Gly Tyr  Gly Leu Ala Ser Thr  Gly Val Thr Ser Gly  Cys Tyr Gln 
    2060                 2065                 2070             


Trp Lys  Phe Tyr Ile Val Lys  Glu Asn Arg Gly Asn  Glu Gly Thr 
    2075                 2080                 2085             


Cys Val  Gly Val Ser Arg Trp  Pro Val His Asp Phe  Asn His Arg 
    2090                 2095                 2100             


Thr Thr  Ser Asp Met Trp Leu  Tyr Arg Ala Tyr Ser  Gly Asn Leu 
    2105                 2110                 2115             


Tyr His  Asn Gly Glu Gln Thr  Leu Thr Leu Ser Ser  Phe Thr Gln 
    2120                 2125                 2130             


Gly Asp  Phe Ile Thr Cys Val  Leu Asp Met Glu Ala  Arg Thr Ile 
    2135                 2140                 2145             


Ser Phe  Gly Lys Asn Gly Glu  Glu Pro Lys Leu Ala  Phe Glu Asp 
    2150                 2155                 2160             


Val Asp  Ala Ala Glu Leu Tyr  Pro Cys Val Met Phe  Tyr Ser Ser 
    2165                 2170                 2175             


Asn Pro  Gly Glu Lys Val Lys  Ile Cys Asp Met Gln  Met Arg Gly 
    2180                 2185                 2190             


Thr Pro  Arg Asp Leu Leu Pro  Gly Asp Pro Ile Cys  Ser Pro Val 
    2195                 2200                 2205             


Ala Ala  Val Leu Ala Glu Ala  Thr Ile Gln Leu Ile  Arg Ile Leu 
    2210                 2215                 2220             


His Arg  Thr Asp Arg Trp Thr  Tyr Cys Ile Asn Lys  Lys Met Met 
    2225                 2230                 2235             


Glu Arg  Leu His Lys Ile Lys  Ile Cys Ile Lys Glu  Ser Gly Gln 
    2240                 2245                 2250             


Lys Leu  Lys Lys Ser Arg Ser  Val Gln Ser Arg Glu  Glu Asn Glu 
    2255                 2260                 2265             


Met Arg  Glu Glu Lys Glu Ser  Lys Glu Glu Glu Lys  Gly Lys His 
    2270                 2275                 2280             


Thr Arg  His Gly Leu Ala Asp  Leu Ser Glu Leu Gln  Leu Arg Thr 
    2285                 2290                 2295             


Leu Cys  Ile Glu Val Trp Pro  Val Leu Ala Val Ile  Gly Gly Val 
    2300                 2305                 2310             


Asp Ala  Gly Leu Arg Val Gly  Gly Arg Cys Val His  Lys Gln Thr 
    2315                 2320                 2325             


Gly Arg  His Ala Thr Leu Leu  Gly Val Val Lys Glu  Gly Ser Thr 
    2330                 2335                 2340             


Ser Ala  Lys Val Gln Trp Asp  Glu Ala Glu Ile Thr  Ile Ser Phe 
    2345                 2350                 2355             


Pro Thr  Phe Trp Ser Pro Ser  Asp Thr Pro Leu Tyr  Asn Leu Glu 
    2360                 2365                 2370             


Pro Cys  Glu Pro Leu Pro Phe  Asp Val Ala Arg Phe  Arg Gly Leu 
    2375                 2380                 2385             


Thr Ala  Ser Val Leu Leu Asp  Leu Thr Tyr Leu Thr  Gly Val His 
    2390                 2395                 2400             


Glu Asp  Met Gly Lys Gln Ser  Thr Lys Arg His Glu  Lys Lys His 
    2405                 2410                 2415             


Arg His  Glu Ser Glu Glu Lys  Gly Asp Val Glu Gln  Lys Pro Glu 
    2420                 2425                 2430             


Ser Glu  Ser Ala Leu Asp Met  Arg Thr Gly Leu Thr  Ser Asp Asp 
    2435                 2440                 2445             


Val Lys  Ser Gln Ser Thr Thr  Ser Ser Lys Ser Glu  Asn Glu Ile 
    2450                 2455                 2460             


Ala Ser  Phe Ser Leu Asp Pro  Thr Leu Pro Ser Val  Glu Ser Gln 
    2465                 2470                 2475             


His Gln  Ile Thr Glu Gly Lys  Arg Lys Asn His Glu  His Met Ser 
    2480                 2485                 2490             


Lys Asn  His Asp Val Ala Gln  Ser Glu Ile Arg Ala  Val Gln Leu 
    2495                 2500                 2505             


Ser Tyr  Leu Tyr Leu Gly Ala  Met Lys Ser Leu Ser  Ala Leu Leu 
    2510                 2515                 2520             


Gly Cys  Ser Lys Tyr Ala Glu  Leu Leu Leu Ile Pro  Lys Val Leu 
    2525                 2530                 2535             


Ala Glu  Asn Gly His Asn Ser  Asp Cys Ala Ser Ser  Pro Val Val 
    2540                 2545                 2550             


His Glu  Asp Val Glu Met Arg  Ala Ala Leu Gln Phe  Leu Met Arg 
    2555                 2560                 2565             


His Met  Val Lys Arg Ala Val  Met Arg Ser Pro Ile  Lys Arg Ala 
    2570                 2575                 2580             


Leu Gly  Leu Ala Asp Leu Glu  Arg Ala Gln Ala Met  Ile Tyr Lys 
    2585                 2590                 2595             


Leu Val  Val His Gly Leu Leu  Glu Asp Gln Phe Gly  Gly Lys Ile 
    2600                 2605                 2610             


Lys Gln  Glu Ile Asp Gln Gln  Ala Glu Glu Ser Asp  Pro Ala Gln 
    2615                 2620                 2625             


Gln Ala  Gln Thr Pro Val Thr  Thr Ser Pro Ser Ala  Ser Ser Thr 
    2630                 2635                 2640             


Thr Ser  Phe Met Ser Ser Ser  Leu Glu Asp Thr Thr  Thr Ala Thr 
    2645                 2650                 2655             


Thr Pro  Val Thr Asp Thr Glu  Thr Val Pro Ala Ser  Glu Ser Pro 
    2660                 2665                 2670             


Gly Val  Met Pro Leu Ser Leu  Leu Arg Gln Met Phe  Ser Ser Tyr 
    2675                 2680                 2685             


Pro Thr  Thr Thr Val Leu Pro  Thr Arg Arg Ala Gln  Thr Pro Pro 
    2690                 2695                 2700             


Ile Ser  Ser Leu Pro Thr Ser  Pro Ser Asp Glu Val  Gly Arg Arg 
    2705                 2710                 2715             


Gln Ser  Leu Thr Ser Pro Asp  Ser Gln Ser Ala Arg  Pro Ala Asn 
    2720                 2725                 2730             


Arg Thr  Ala Leu Ser Asp Pro  Ser Ser Arg Leu Ser  Thr Ser Pro 
    2735                 2740                 2745             


Pro Pro  Pro Ala Ile Ala Val  Pro Leu Leu Glu Met  Gly Phe Ser 
    2750                 2755                 2760             


Leu Arg  Gln Ile Ala Lys Ala  Met Glu Ala Thr Gly  Ala Arg Gly 
    2765                 2770                 2775             


Glu Ala  Asp Ala Gln Asn Ile  Thr Val Leu Ala Met  Trp Met Ile 
    2780                 2785                 2790             


Glu His  Pro Gly His Glu Asp  Glu Glu Glu Pro Gln  Ser Gly Ser 
    2795                 2800                 2805             


Thr Ala  Asp Ser Arg Pro Gly  Ala Ala Val Leu Gly  Ser Gly Gly 
    2810                 2815                 2820             


Lys Ser  Asn Asp Pro Cys Tyr  Leu Gln Ser Pro Gly  Asp Ile Pro 
    2825                 2830                 2835             


Ser Ala  Asp Ala Ala Glu Met  Glu Glu Gly Phe Ser  Glu Ser Pro 
    2840                 2845                 2850             


Asp Asn  Leu Asp His Thr Glu  Asn Ala Ala Ser Gly  Ser Gly Pro 
    2855                 2860                 2865             


Ser Ala  Arg Gly Arg Ser Ala  Val Thr Arg Arg His  Lys Phe Asp 
    2870                 2875                 2880             


Leu Ala  Ala Arg Thr Leu Leu  Ala Arg Ala Ala Gly  Leu Tyr Arg 
    2885                 2890                 2895             


Ser Val  Gln Ala His Arg Asn  Gln Ser Arg Arg Glu  Gly Ile Ser 
    2900                 2905                 2910             


Leu Gln  Gln Asp Pro Gly Ala  Leu Tyr Asp Phe Asn  Leu Asp Glu 
    2915                 2920                 2925             


Glu Leu  Glu Ile Asp Leu Asp  Asp Glu Ala Met Glu  Ala Met Phe 
    2930                 2935                 2940             


Gly Gln  Asp Leu Thr Ser Asp  Asn Asp Ile Leu Gly  Met Trp Ile 
    2945                 2950                 2955             


Pro Glu  Val Leu Asp Trp Pro  Thr Trp His Val Cys  Glu Ser Glu 
    2960                 2965                 2970             


Asp Arg  Glu Glu Val Val Val  Cys Glu Leu Cys Glu  Cys Ser Val 
    2975                 2980                 2985             


Val Ser  Phe Asn Gln His Met  Lys Arg Asn His Pro  Gly Cys Gly 
    2990                 2995                 3000             


Arg Ser  Ala Asn Arg Gln Gly  Tyr Arg Ser Asn Gly  Ser Tyr Val 
    3005                 3010                 3015             


Asp Gly  Trp Phe Gly Gly Glu  Cys Gly Ser Gly Asn  Pro Tyr Tyr 
    3020                 3025                 3030             


Leu Leu  Cys Gly Thr Cys Arg  Glu Lys Tyr Leu Ala  Met Lys Thr 
    3035                 3040                 3045             


Lys Ser  Lys Ser Thr Ser Ser  Glu Arg Tyr Lys Gly  Gln Ala Pro 
    3050                 3055                 3060             


Asp Leu  Ile Gly Lys Gln Asp  Ser Val Tyr Glu Glu  Asp Trp Asp 
    3065                 3070                 3075             


Met Leu  Asp Val Asp Glu Asp  Glu Lys Leu Thr Gly  Glu Glu Glu 
    3080                 3085                 3090             


Phe Glu  Leu Leu Ala Gly Pro  Leu Gly Leu Asn Asp  Arg Arg Ile 
    3095                 3100                 3105             


Val Pro  Glu Pro Val Gln Phe  Pro Asp Ser Asp Pro  Leu Gly Ala 
    3110                 3115                 3120             


Ser Val  Ala Met Val Thr Ala  Thr Asn Ser Met Glu  Glu Thr Leu 
    3125                 3130                 3135             


Met Gln  Ile Gly Cys His Gly  Ser Val Glu Lys Ser  Ser Ser Gly 
    3140                 3145                 3150             


Arg Ile  Thr Leu Gly Glu Gln  Ala Ala Ala Leu Ala  Asn Pro His 
    3155                 3160                 3165             


Asp Arg  Val Val Ala Leu Arg  Arg Val Thr Ala Ala  Ala Gln Val 
    3170                 3175                 3180             


Leu Leu  Ala Arg Thr Met Val  Met Arg Ala Leu Ser  Leu Leu Ser 
    3185                 3190                 3195             


Val Ser  Gly Ser Ser Cys Ser  Leu Ala Ala Gly Leu  Glu Ser Leu 
    3200                 3205                 3210             


Gly Leu  Thr Asp Ile Arg Thr  Leu Val Arg Leu Met  Cys Leu Ala 
    3215                 3220                 3225             


Ala Ala  Gly Arg Ala Gly Leu  Ser Thr Ser Pro Ser  Ala Met Ala 
    3230                 3235                 3240             


Ser Thr  Ser Glu Arg Ser Arg  Gly Gly His Ser Lys  Ala Asn Lys 
    3245                 3250                 3255             


Pro Ile  Ser Cys Leu Ala Tyr  Leu Ser Thr Ala Val  Gly Cys Leu 
    3260                 3265                 3270             


Ala Ser  Asn Ala Pro Ser Ala  Ala Lys Leu Leu Val  Gln Leu Cys 
    3275                 3280                 3285             


Thr Gln  Asn Leu Ile Ser Ala  Ala Thr Gly Val Asn  Leu Thr Thr 
    3290                 3295                 3300             


Val Asp  Asp Ser Ile Gln Arg  Lys Phe Leu Pro Ser  Phe Leu Arg 
    3305                 3310                 3315             


Gly Ile  Ala Glu Glu Asn Lys  Leu Val Thr Ser Pro  Asn Phe Val 
    3320                 3325                 3330             


Val Thr  Gln Ala Leu Val Ala  Leu Leu Ala Asp Lys  Gly Ala Lys 
    3335                 3340                 3345             


Leu Arg  Pro Asn Tyr Asp Lys  Ser Glu Val Glu Lys  Lys Gly Pro 
    3350                 3355                 3360             


Leu Glu  Leu Ala Asn Ala Leu  Ala Ala Cys Cys Leu  Ser Ser Arg 
    3365                 3370                 3375             


Leu Ser  Ser Gln His Arg Gln  Trp Ala Ala Gln Gln  Leu Val Arg 
    3380                 3385                 3390             


Thr Leu  Ala Ala His Asp Arg  Asp Asn Gln Thr Thr  Leu Gln Thr 
    3395                 3400                 3405             


Leu Ala  Asp Met Gly Gly Asp  Leu Arg Lys Cys Ser  Phe Ile Lys 
    3410                 3415                 3420             


Leu Glu  Ala His Gln Asn Arg  Val Met Thr Cys Val  Trp Cys Asn 
    3425                 3430                 3435             


Lys Lys  Gly Leu Leu Ala Thr  Ser Gly Asn Asp Gly  Thr Ile Arg 
    3440                 3445                 3450             


Val Trp  Asn Val Thr Lys Lys  Gln Tyr Ser Leu Gln  Gln Thr Cys 
    3455                 3460                 3465             


Val Phe  Asn Arg Leu Glu Gly  Asp Ala Glu Glu Ser  Leu Gly Ser 
    3470                 3475                 3480             


Pro Ser  Asp Pro Ser Phe Ser  Pro Val Ser Trp Ser  Ile Ser Gly 
    3485                 3490                 3495             


Lys Tyr  Leu Ala Gly Ala Leu  Glu Lys Met Val Asn  Ile Trp Gln 
    3500                 3505                 3510             


Val Asn  Gly Gly Lys Gly Leu  Val Asp Ile Gln Pro  His Trp Val 
    3515                 3520                 3525             


Ser Ala  Leu Ala Trp Pro Glu  Glu Gly Pro Ala Thr  Ala Trp Ser 
    3530                 3535                 3540             


Gly Glu  Ser Pro Glu Leu Leu  Leu Val Gly Arg Met  Asp Gly Ser 
    3545                 3550                 3555             


Leu Gly  Leu Ile Glu Val Val  Asp Val Ser Thr Met  His Arg Arg 
    3560                 3565                 3570             


Glu Leu  Glu His Cys Tyr Arg  Lys Asp Val Ser Val  Thr Cys Ile 
    3575                 3580                 3585             


Ala Trp  Phe Ser Glu Asp Arg  Pro Phe Ala Val Gly  Tyr Phe Asp 
    3590                 3595                 3600             


Gly Lys  Leu Leu Leu Gly Thr  Lys Glu Pro Leu Glu  Lys Gly Gly 
    3605                 3610                 3615             


Ile Val  Leu Ile Asp Ala His  Lys Asp Thr Leu Ile  Ser Met Lys 
    3620                 3625                 3630             


Trp Asp  Pro Thr Gly His Ile  Leu Met Thr Cys Ala  Lys Glu Asp 
    3635                 3640                 3645             


Ser Val  Lys Leu Trp Gly Ser  Ile Ser Gly Cys Trp  Cys Cys Leu 
    3650                 3655                 3660             


His Ser  Leu Cys His Pro Ser  Ile Val Asn Gly Ile  Ala Trp Cys 
    3665                 3670                 3675             


Arg Leu  Pro Gly Lys Gly Ser  Lys Leu Gln Leu Leu  Met Ala Thr 
    3680                 3685                 3690             


Gly Cys  Gln Ser Gly Leu Val  Cys Val Trp Arg Ile  Pro Gln Asp 
    3695                 3700                 3705             


Thr Thr  Gln Thr Asn Val Thr  Ser Ala Glu Gly Trp  Trp Glu Gln 
    3710                 3715                 3720             


Glu Ser  Asn Cys Gln Asp Gly  Tyr Arg Lys Ser Ser  Gly Ala Lys 
    3725                 3730                 3735             


Cys Val  Tyr Gln Leu Arg Gly  His Ile Thr Pro Val  Arg Thr Val 
    3740                 3745                 3750             


Ala Phe  Ser Ser Asp Gly Leu  Ala Leu Val Ser Gly  Gly Leu Gly 
    3755                 3760                 3765             


Gly Leu  Met Asn Ile Trp Ser  Leu Arg Asp Gly Ser  Val Leu Gln 
    3770                 3775                 3780             


Thr Val  Val Ile Gly Ser Gly  Ala Ile Gln Thr Thr  Val Trp Ile 
    3785                 3790                 3795             


Pro Glu  Val Gly Val Ala Ala  Cys Ser Asn Arg Ser  Lys Asp Val 
    3800                 3805                 3810             


Leu Val  Val Asn Cys Thr Ala  Glu Trp Ala Ala Ala  Asn His Val 
    3815                 3820                 3825             


Leu Ala  Thr Cys Arg Thr Ala  Leu Lys Gln Gln Gly  Val Leu Gly 
    3830                 3835                 3840             


Leu Asn  Met Ala Pro Cys Met  Arg Ala Phe Leu Glu  Arg Leu Pro 
    3845                 3850                 3855             


Met Met  Leu Gln Glu Gln Tyr  Ala Tyr Glu Lys Pro  His Val Val 
    3860                 3865                 3870             


Cys Gly  Asp Gln Leu Val His  Ser Pro Tyr Met Gln  Cys Leu Ala 
    3875                 3880                 3885             


Ser Leu  Ala Val Gly Leu His  Leu Asp Gln Leu Leu  Cys Asn Pro 
    3890                 3895                 3900             


Pro Val  Pro Pro His His Gln  Asn Cys Leu Pro Asp  Pro Ala Ser 
    3905                 3910                 3915             


Trp Asn  Pro Asn Glu Trp Ala  Trp Leu Glu Cys Phe  Ser Thr Thr 
    3920                 3925                 3930             


Ile Lys  Ala Ala Glu Ala Leu  Thr Asn Gly Ala Gln  Phe Pro Glu 
    3935                 3940                 3945             


Ser Phe  Thr Val Pro Asp Leu  Glu Pro Val Pro Glu  Asp Glu Leu 
    3950                 3955                 3960             


Val Phe  Leu Met Asp Asn Ser  Lys Trp Ile Asn Gly  Met Asp Glu 
    3965                 3970                 3975             


Gln Ile  Met Ser Trp Ala Thr  Ser Arg Pro Glu Asp  Trp His Leu 
    3980                 3985                 3990             


Gly Gly  Lys Cys Asp Val Tyr  Leu Trp Gly Ala Gly  Arg His Gly 
    3995                 4000                 4005             


Gln Leu  Ala Glu Ala Gly Arg  Asn Val Met Val Pro  Ala Ala Ala 
    4010                 4015                 4020             


Pro Ser  Phe Ser Gln Ala Gln  Gln Val Ile Cys Gly  Gln Asn Cys 
    4025                 4030                 4035             


Thr Phe  Val Ile Gln Ala Asn  Gly Thr Val Leu Ala  Cys Gly Glu 
    4040                 4045                 4050             


Gly Ser  Tyr Gly Arg Leu Gly  Gln Gly Asn Ser Asp  Asp Leu His 
    4055                 4060                 4065             


Val Leu  Thr Val Ile Ser Ala  Leu Gln Gly Phe Val  Val Thr Gln 
    4070                 4075                 4080             


Leu Val  Thr Ser Cys Gly Ser  Asp Gly His Ser Met  Ala Leu Thr 
    4085                 4090                 4095             


Glu Ser  Gly Glu Val Phe Ser  Trp Gly Asp Gly Asp  Tyr Gly Lys 
    4100                 4105                 4110             


Leu Gly  His Gly Asn Ser Asp  Arg Gln Arg Arg Pro  Arg Gln Ile 
    4115                 4120                 4125             


Glu Ala  Leu Gln Gly Glu Glu  Val Val Gln Met Ser  Cys Gly Phe 
    4130                 4135                 4140             


Lys His  Ser Ala Val Val Thr  Ser Asp Gly Lys Leu  Phe Thr Phe 
    4145                 4150                 4155             


Gly Asn  Gly Asp Tyr Gly Arg  Leu Gly Leu Gly Asn  Thr Ser Asn 
    4160                 4165                 4170             


Lys Lys  Leu Pro Glu Arg Val  Thr Ala Leu Glu Gly  Tyr Gln Ile 
    4175                 4180                 4185             


Gly Gln  Val Ala Cys Gly Leu  Asn His Thr Leu Ala  Val Ser Ala 
    4190                 4195                 4200             


Asp Gly  Ser Met Val Trp Ala  Phe Gly Asp Gly Asp  Tyr Gly Lys 
    4205                 4210                 4215             


Leu Gly  Leu Gly Asn Ser Thr  Ala Lys Ser Ser Pro  Gln Lys Ile 
    4220                 4225                 4230             


Asp Val  Leu Cys Gly Ile Gly  Ile Lys Lys Val Ala  Cys Gly Thr 
    4235                 4240                 4245             


Gln Phe  Ser Val Ala Leu Thr  Lys Asp Gly His Val  Tyr Thr Phe 
    4250                 4255                 4260             


Gly Gln  Asp Arg Leu Ile Gly  Leu Pro Glu Gly Arg  Ala Arg Asn 
    4265                 4270                 4275             


His Asn  Arg Pro Gln Gln Ile  Pro Val Leu Ala Gly  Val Ile Ile 
    4280                 4285                 4290             


Glu Asp  Val Ala Val Gly Ala  Glu His Thr Leu Ala  Leu Ala Ser 
    4295                 4300                 4305             


Asn Gly  Asp Val Tyr Ala Trp  Gly Ser Asn Ser Glu  Gly Gln Leu 
    4310                 4315                 4320             


Gly Leu  Gly His Thr Asn His  Val Arg Glu Pro Thr  Leu Val Thr 
    4325                 4330                 4335             


Gly Leu  Gln Gly Lys Asn Val  Arg Gln Ile Ser Ala  Gly Arg Cys 
    4340                 4345                 4350             


His Ser  Ala Ala Trp Thr Ala  Pro Pro Val Pro Pro  Arg Ala Pro 
    4355                 4360                 4365             


Gly Val  Ser Val Pro Leu Gln  Leu Gly Leu Pro Asp  Thr Val Pro 
    4370                 4375                 4380             


Pro Gln  Tyr Gly Ala Leu Arg  Glu Val Ser Ile His  Thr Val Arg 
    4385                 4390                 4395             


Ala Arg  Leu Arg Leu Leu Tyr  His Phe Ser Asp Leu  Met Tyr Ser 
    4400                 4405                 4410             


Ser Trp  Arg Leu Leu Asn Leu  Ser Pro Asn Asn Gln  Asn Ser Thr 
    4415                 4420                 4425             


Ser His  Tyr Asn Ala Gly Thr  Trp Gly Ile Val Gln  Gly Gln Leu 
    4430                 4435                 4440             


Arg Pro  Leu Leu Ala Pro Arg  Val Tyr Thr Leu Pro  Met Val Arg 
    4445                 4450                 4455             


Ser Ile  Gly Lys Thr Met Val  Gln Gly Lys Asn Tyr  Gly Pro Gln 
    4460                 4465                 4470             


Ile Thr  Val Lys Arg Ile Ser  Thr Arg Gly Arg Lys  Cys Lys Pro 
    4475                 4480                 4485             


Ile Phe  Val Gln Ile Ala Arg  Gln Val Val Lys Leu  Asn Ala Ser 
    4490                 4495                 4500             


Asp Leu  Arg Leu Pro Ser Arg  Ala Trp Lys Val Lys  Leu Val Gly 
    4505                 4510                 4515             


Glu Gly  Ala Asp Asp Ala Gly  Gly Val Phe Asp Asp  Thr Ile Thr 
    4520                 4525                 4530             


Glu Met  Cys Gln Glu Leu Glu  Thr Gly Ile Val Asp  Leu Leu Ile 
    4535                 4540                 4545             


Pro Ser  Pro Asn Ala Thr Ala  Glu Val Gly Tyr Asn  Arg Asp Arg 
    4550                 4555                 4560             


Phe Leu  Phe Asn Pro Ser Ala  Cys Leu Asp Glu His  Leu Met Gln 
    4565                 4570                 4575             


Phe Lys  Phe Leu Gly Ile Leu  Met Gly Val Ala Ile  Arg Thr Lys 
    4580                 4585                 4590             


Lys Pro  Leu Asp Leu His Leu  Ala Pro Leu Val Trp  Lys Gln Leu 
    4595                 4600                 4605             


Cys Cys  Val Pro Leu Thr Leu  Glu Asp Leu Glu Glu  Val Asp Leu 
    4610                 4615                 4620             


Leu Tyr  Val Gln Thr Leu Asn  Ser Ile Leu His Ile  Glu Asp Ser 
    4625                 4630                 4635             


Gly Ile  Thr Glu Glu Ser Phe  His Glu Met Ile Pro  Leu Asp Ser 
    4640                 4645                 4650             


Phe Val  Gly Gln Ser Ala Asp  Gly Lys Met Val Pro  Ile Ile Pro 
    4655                 4660                 4665             


Gly Gly  Asn Ser Ile Pro Leu  Thr Phe Ser Asn Arg  Lys Glu Tyr 
    4670                 4675                 4680             


Val Glu  Arg Ala Ile Glu Tyr  Arg Leu His Glu Met  Asp Arg Gln 
    4685                 4690                 4695             


Val Ala  Ala Val Arg Glu Gly  Met Ser Trp Ile Val  Pro Val Pro 
    4700                 4705                 4710             


Leu Leu  Ser Leu Leu Thr Ala  Lys Gln Leu Glu Gln  Met Val Cys 
    4715                 4720                 4725             


Gly Met  Pro Glu Ile Ser Val  Glu Val Leu Lys Lys  Val Val Arg 
    4730                 4735                 4740             


Tyr Arg  Glu Val Asp Glu Gln  His Gln Leu Val Gln  Trp Phe Trp 
    4745                 4750                 4755             


His Thr  Leu Glu Glu Phe Ser  Asn Glu Glu Arg Val  Leu Phe Met 
    4760                 4765                 4770             


Arg Phe  Val Ser Gly Arg Ser  Arg Leu Pro Ala Asn  Thr Ala Asp 
    4775                 4780                 4785             


Ile Ser  Gln Arg Phe Gln Ile  Met Lys Val Asp Arg  Pro Tyr Asp 
    4790                 4795                 4800             


Ser Leu  Pro Thr Ser Gln Thr  Cys Phe Phe Gln Leu  Arg Leu Pro 
    4805                 4810                 4815             


Pro Tyr  Ser Ser Gln Leu Val  Met Ala Glu Arg Leu  Arg Tyr Ala 
    4820                 4825                 4830             


Ile Asn  Asn Cys Arg Ser Ile  Asp Met Asp Asn Tyr  Met Leu Ser 
    4835                 4840                 4845             


Arg Asn  Val Asp Asn Ala Glu  Gly Ser Asp Thr Asp  Tyr 
    4850                 4855                 4860     


<210>  4941
<211>  4834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HERC2__Homo_sapiens__NP_004658

<400>  4941

Met Pro Ser Glu Ser Phe Cys Leu Ala Ala Gln Ala Arg Leu Asp Ser 
1               5                   10                  15      


Lys Trp Leu Lys Thr Asp Ile Gln Leu Ala Phe Thr Arg Asp Gly Leu 
            20                  25                  30          


Cys Gly Leu Trp Asn Glu Met Val Lys Asp Gly Glu Ile Val Tyr Thr 
        35                  40                  45              


Gly Thr Glu Ser Thr Gln Asn Gly Glu Leu Pro Pro Arg Lys Asp Asp 
    50                  55                  60                  


Ser Val Glu Pro Ser Gly Thr Lys Lys Glu Asp Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Lys Lys Asp Glu Glu Glu Thr Pro Ala Pro Ile Tyr Arg Ala Lys Ser 
                85                  90                  95      


Ile Leu Asp Ser Trp Val Trp Gly Lys Gln Pro Asp Val Asn Glu Leu 
            100                 105                 110         


Lys Glu Cys Leu Ser Val Leu Val Lys Glu Gln Gln Ala Leu Ala Val 
        115                 120                 125             


Gln Ser Ala Thr Thr Thr Leu Ser Ala Leu Arg Leu Lys Gln Arg Leu 
    130                 135                 140                 


Val Ile Leu Glu Arg Tyr Phe Ile Ala Leu Asn Arg Thr Val Phe Gln 
145                 150                 155                 160 


Glu Asn Val Lys Val Lys Trp Lys Ser Ser Gly Ile Ser Leu Pro Pro 
                165                 170                 175     


Val Asp Lys Lys Ser Ser Arg Pro Ala Gly Lys Gly Val Glu Gly Leu 
            180                 185                 190         


Ala Arg Val Gly Ser Arg Ala Ala Leu Ser Phe Ala Phe Ala Phe Leu 
        195                 200                 205             


Arg Arg Ala Trp Arg Ser Gly Glu Asp Ala Asp Leu Cys Ser Glu Leu 
    210                 215                 220                 


Leu Gln Glu Ser Leu Asp Ala Leu Arg Ala Leu Pro Glu Ala Ser Leu 
225                 230                 235                 240 


Phe Asp Glu Ser Thr Val Ser Ser Val Trp Leu Glu Val Val Glu Arg 
                245                 250                 255     


Ala Thr Arg Phe Leu Arg Ser Val Val Thr Gly Asp Val His Gly Thr 
            260                 265                 270         


Pro Ala Thr Lys Gly Pro Gly Ser Ile Pro Leu Gln Asp Gln His Leu 
        275                 280                 285             


Ala Leu Ala Ile Leu Leu Glu Leu Ala Val Gln Arg Gly Thr Leu Ser 
    290                 295                 300                 


Gln Met Leu Ser Ala Ile Leu Leu Leu Leu Gln Leu Trp Asp Ser Gly 
305                 310                 315                 320 


Ala Gln Glu Thr Asp Asn Glu Arg Ser Ala Gln Gly Thr Ser Ala Pro 
                325                 330                 335     


Leu Leu Pro Leu Leu Gln Arg Phe Gln Ser Ile Ile Cys Arg Lys Asp 
            340                 345                 350         


Ala Pro His Ser Glu Gly Asp Met His Leu Leu Ser Gly Pro Leu Ser 
        355                 360                 365             


Pro Asn Glu Ser Phe Leu Arg Tyr Leu Thr Leu Pro Gln Asp Asn Glu 
    370                 375                 380                 


Leu Ala Ile Asp Leu Arg Gln Thr Ala Val Val Val Met Ala His Leu 
385                 390                 395                 400 


Asp Arg Leu Ala Thr Pro Cys Met Pro Pro Leu Cys Ser Ser Pro Thr 
                405                 410                 415     


Ser His Lys Gly Ser Leu Gln Glu Val Ile Gly Trp Gly Leu Ile Gly 
            420                 425                 430         


Trp Lys Tyr Tyr Ala Asn Val Ile Gly Pro Ile Gln Cys Glu Gly Leu 
        435                 440                 445             


Ala Asn Leu Gly Val Thr Gln Ile Ala Cys Ala Glu Lys Arg Phe Leu 
    450                 455                 460                 


Ile Leu Ser Arg Asn Gly Arg Val Tyr Thr Gln Ala Tyr Asn Ser Asp 
465                 470                 475                 480 


Thr Leu Ala Pro Gln Leu Val Gln Gly Leu Ala Ser Arg Asn Ile Val 
                485                 490                 495     


Lys Ile Ala Ala His Ser Asp Gly His His Tyr Leu Ala Leu Ala Ala 
            500                 505                 510         


Thr Gly Glu Val Tyr Ser Trp Gly Cys Gly Asp Gly Gly Arg Leu Gly 
        515                 520                 525             


His Gly Asp Thr Val Pro Leu Glu Glu Pro Lys Val Ile Ser Ala Phe 
    530                 535                 540                 


Ser Gly Lys Gln Ala Gly Lys His Val Val His Ile Ala Cys Gly Ser 
545                 550                 555                 560 


Thr Tyr Ser Ala Ala Ile Thr Ala Glu Gly Glu Leu Tyr Thr Trp Gly 
                565                 570                 575     


Arg Gly Asn Tyr Gly Arg Leu Gly His Gly Ser Ser Glu Asp Glu Ala 
            580                 585                 590         


Ile Pro Met Leu Val Ala Gly Leu Lys Gly Leu Lys Val Ile Asp Val 
        595                 600                 605             


Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Ala Val Thr Glu Asn Gly 
    610                 615                 620                 


Gln Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly Arg Gly 
625                 630                 635                 640 


Gly Ser Asp Gly Cys Lys Thr Pro Lys Leu Ile Glu Lys Leu Gln Asp 
                645                 650                 655     


Leu Asp Val Val Lys Val Arg Cys Gly Ser Gln Phe Ser Ile Ala Leu 
            660                 665                 670         


Thr Lys Asp Gly Gln Val Tyr Ser Trp Gly Lys Gly Asp Asn Gln Arg 
        675                 680                 685             


Leu Gly His Gly Thr Glu Glu His Val Arg Tyr Pro Lys Leu Leu Glu 
    690                 695                 700                 


Gly Leu Gln Gly Lys Lys Val Ile Asp Val Ala Ala Gly Ser Thr His 
705                 710                 715                 720 


Cys Leu Ala Leu Thr Glu Asp Ser Glu Val His Ser Trp Gly Ser Asn 
                725                 730                 735     


Asp Gln Cys Gln His Phe Asp Thr Leu Arg Val Thr Lys Pro Glu Pro 
            740                 745                 750         


Ala Ala Leu Pro Gly Leu Asp Thr Lys His Ile Val Gly Ile Ala Cys 
        755                 760                 765             


Gly Pro Ala Gln Ser Phe Ala Trp Ser Ser Cys Ser Glu Trp Ser Ile 
    770                 775                 780                 


Gly Leu Arg Val Pro Phe Val Val Asp Ile Cys Ser Met Thr Phe Glu 
785                 790                 795                 800 


Gln Leu Asp Leu Leu Leu Arg Gln Val Ser Glu Gly Met Asp Gly Ser 
                805                 810                 815     


Ala Asp Trp Pro Pro Pro Gln Glu Lys Glu Cys Val Ala Val Ala Thr 
            820                 825                 830         


Leu Asn Leu Leu Arg Leu Gln Leu His Ala Ala Ile Ser His Gln Val 
        835                 840                 845             


Asp Pro Glu Phe Leu Gly Leu Gly Leu Gly Ser Ile Leu Leu Asn Ser 
    850                 855                 860                 


Leu Lys Gln Thr Val Val Thr Leu Ala Ser Ser Ala Gly Val Leu Ser 
865                 870                 875                 880 


Thr Val Gln Ser Ala Ala Gln Ala Val Leu Gln Ser Gly Trp Ser Val 
                885                 890                 895     


Leu Leu Pro Thr Ala Glu Glu Arg Ala Arg Ala Leu Ser Ala Leu Leu 
            900                 905                 910         


Pro Cys Ala Val Ser Gly Asn Glu Val Asn Ile Ser Pro Gly Arg Arg 
        915                 920                 925             


Phe Met Ile Asp Leu Leu Val Gly Ser Leu Met Ala Asp Gly Gly Leu 
    930                 935                 940                 


Glu Ser Ala Leu His Ala Ala Ile Thr Ala Glu Ile Gln Asp Ile Glu 
945                 950                 955                 960 


Ala Lys Lys Glu Ala Gln Lys Glu Lys Glu Ile Asp Glu Gln Glu Ala 
                965                 970                 975     


Asn Ala Ser Thr Phe His Arg Ser Arg Thr Pro Leu Asp Lys Asp Leu 
            980                 985                 990         


Ile Asn Thr Gly Ile Cys Glu Ser  Ser Gly Lys Gln Cys  Leu Pro Leu 
        995                 1000                 1005             


Val Gln  Leu Ile Gln Gln Leu  Leu Arg Asn Ile Ala  Ser Gln Thr 
    1010                 1015                 1020             


Val Ala  Arg Leu Lys Asp Val  Ala Arg Arg Ile Ser  Ser Cys Leu 
    1025                 1030                 1035             


Asp Phe  Glu Gln His Ser Arg  Glu Arg Ser Ala Ser  Leu Asp Leu 
    1040                 1045                 1050             


Leu Leu  Arg Phe Gln Arg Leu  Leu Ile Ser Lys Leu  Tyr Pro Gly 
    1055                 1060                 1065             


Glu Ser  Ile Gly Gln Thr Ser  Asp Ile Ser Ser Pro  Glu Leu Met 
    1070                 1075                 1080             


Gly Val  Gly Ser Leu Leu Lys  Lys Tyr Thr Ala Leu  Leu Cys Thr 
    1085                 1090                 1095             


His Ile  Gly Asp Ile Leu Pro  Val Ala Ala Ser Ile  Ala Ser Thr 
    1100                 1105                 1110             


Ser Trp  Arg His Phe Ala Glu  Val Ala Tyr Ile Val  Glu Gly Asp 
    1115                 1120                 1125             


Phe Thr  Gly Val Leu Leu Pro  Glu Leu Val Val Ser  Ile Val Leu 
    1130                 1135                 1140             


Leu Leu  Ser Lys Asn Ala Gly  Leu Met Gln Glu Ala  Gly Ala Val 
    1145                 1150                 1155             


Pro Leu  Leu Gly Gly Leu Leu  Glu His Leu Asp Arg  Phe Asn His 
    1160                 1165                 1170             


Leu Ala  Pro Gly Lys Glu Arg  Asp Asp His Glu Glu  Leu Ala Trp 
    1175                 1180                 1185             


Pro Gly  Ile Met Glu Ser Phe  Phe Thr Gly Gln Asn  Cys Arg Asn 
    1190                 1195                 1200             


Asn Glu  Glu Val Thr Leu Ile  Arg Lys Ala Asp Leu  Glu Asn His 
    1205                 1210                 1215             


Asn Lys  Asp Gly Gly Phe Trp  Thr Val Ile Asp Gly  Lys Val Tyr 
    1220                 1225                 1230             


Asp Ile  Lys Asp Phe Gln Thr  Gln Ser Leu Thr Gly  Asn Ser Ile 
    1235                 1240                 1245             


Leu Ala  Gln Phe Ala Gly Glu  Asp Pro Val Val Ala  Leu Glu Ala 
    1250                 1255                 1260             


Ala Leu  Gln Phe Glu Asp Thr  Arg Glu Ser Met His  Ala Phe Cys 
    1265                 1270                 1275             


Val Gly  Gln Tyr Leu Glu Pro  Asp Gln Glu Ile Val  Thr Ile Pro 
    1280                 1285                 1290             


Asp Leu  Gly Ser Leu Ser Ser  Pro Leu Ile Asp Thr  Glu Arg Asn 
    1295                 1300                 1305             


Leu Gly  Leu Leu Leu Gly Leu  His Ala Ser Tyr Leu  Ala Met Ser 
    1310                 1315                 1320             


Thr Pro  Leu Ser Pro Val Glu  Ile Glu Cys Ala Lys  Trp Leu Gln 
    1325                 1330                 1335             


Ser Ser  Ile Phe Ser Gly Gly  Leu Gln Thr Ser Gln  Ile His Tyr 
    1340                 1345                 1350             


Ser Tyr  Asn Glu Glu Lys Asp  Glu Asp His Cys Ser  Ser Pro Gly 
    1355                 1360                 1365             


Gly Thr  Pro Ala Ser Lys Ser  Arg Leu Cys Ser His  Arg Arg Ala 
    1370                 1375                 1380             


Leu Gly  Asp His Ser Gln Ala  Phe Leu Gln Ala Ile  Ala Asp Asn 
    1385                 1390                 1395             


Asn Ile  Gln Asp His Asn Val  Lys Asp Phe Leu Cys  Gln Ile Glu 
    1400                 1405                 1410             


Arg Tyr  Cys Arg Gln Cys His  Leu Thr Thr Pro Ile  Met Phe Pro 
    1415                 1420                 1425             


Pro Glu  His Pro Val Glu Glu  Val Gly Arg Leu Leu  Leu Cys Cys 
    1430                 1435                 1440             


Leu Leu  Lys His Glu Asp Leu  Gly His Val Ala Leu  Ser Leu Val 
    1445                 1450                 1455             


His Ala  Gly Ala Leu Gly Ile  Glu Gln Val Lys His  Arg Thr Leu 
    1460                 1465                 1470             


Pro Lys  Ser Val Val Asp Val  Cys Arg Val Val Tyr  Gln Ala Lys 
    1475                 1480                 1485             


Cys Ser  Leu Ile Lys Thr His  Gln Glu Gln Gly Arg  Ser Tyr Lys 
    1490                 1495                 1500             


Glu Val  Cys Ala Pro Val Ile  Glu Arg Leu Arg Phe  Leu Phe Asn 
    1505                 1510                 1515             


Glu Leu  Arg Pro Ala Val Cys  Asn Asp Leu Ser Ile  Met Ser Lys 
    1520                 1525                 1530             


Phe Lys  Leu Leu Ser Ser Leu  Pro Arg Trp Arg Arg  Ile Ala Gln 
    1535                 1540                 1545             


Lys Ile  Ile Arg Glu Arg Arg  Lys Lys Arg Val Pro  Lys Lys Pro 
    1550                 1555                 1560             


Glu Ser  Thr Asp Asp Glu Glu  Lys Ile Gly Asn Glu  Glu Ser Asp 
    1565                 1570                 1575             


Leu Glu  Glu Ala Cys Ile Leu  Pro His Ser Pro Ile  Asn Val Asp 
    1580                 1585                 1590             


Lys Arg  Pro Ile Ala Ile Lys  Ser Pro Lys Asp Lys  Trp Gln Pro 
    1595                 1600                 1605             


Leu Leu  Ser Thr Val Thr Gly  Val His Lys Tyr Lys  Trp Leu Lys 
    1610                 1615                 1620             


Gln Asn  Val Gln Gly Leu Tyr  Pro Gln Ser Pro Leu  Leu Ser Thr 
    1625                 1630                 1635             


Ile Ala  Glu Phe Ala Leu Lys  Glu Glu Pro Val Asp  Val Glu Lys 
    1640                 1645                 1650             


Met Arg  Lys Cys Leu Leu Lys  Gln Leu Glu Arg Ala  Glu Val Arg 
    1655                 1660                 1665             


Leu Glu  Gly Ile Asp Thr Ile  Leu Lys Leu Ala Ser  Lys Asn Phe 
    1670                 1675                 1680             


Leu Leu  Pro Ser Val Gln Tyr  Ala Met Phe Cys Gly  Trp Gln Arg 
    1685                 1690                 1695             


Leu Ile  Pro Glu Gly Ile Asp  Ile Gly Glu Pro Leu  Thr Asp Cys 
    1700                 1705                 1710             


Leu Lys  Asp Val Asp Leu Ile  Pro Pro Phe Asn Arg  Met Leu Leu 
    1715                 1720                 1725             


Glu Val  Thr Phe Gly Lys Leu  Tyr Ala Trp Ala Val  Gln Asn Ile 
    1730                 1735                 1740             


Arg Asn  Val Leu Met Asp Ala  Ser Ala Lys Phe Lys  Glu Leu Gly 
    1745                 1750                 1755             


Ile Gln  Pro Val Pro Leu Gln  Thr Ile Thr Asn Glu  Asn Pro Ser 
    1760                 1765                 1770             


Gly Pro  Ser Leu Gly Thr Ile  Pro Gln Ala Arg Phe  Leu Leu Val 
    1775                 1780                 1785             


Met Leu  Ser Met Leu Thr Leu  Gln His Gly Ala Asn  Asn Leu Asp 
    1790                 1795                 1800             


Leu Leu  Leu Asn Ser Gly Met  Leu Ala Leu Thr Gln  Thr Ala Leu 
    1805                 1810                 1815             


Arg Leu  Ile Gly Pro Ser Cys  Asp Asn Val Glu Glu  Asp Met Asn 
    1820                 1825                 1830             


Ala Ser  Ala Gln Gly Ala Ser  Ala Thr Val Leu Glu  Glu Thr Arg 
    1835                 1840                 1845             


Lys Glu  Thr Ala Pro Val Gln  Leu Pro Val Ser Gly  Pro Glu Leu 
    1850                 1855                 1860             


Ala Ala  Met Met Lys Ile Gly  Thr Arg Val Met Arg  Gly Val Asp 
    1865                 1870                 1875             


Trp Lys  Trp Gly Asp Gln Asp  Gly Pro Pro Pro Gly  Leu Gly Arg 
    1880                 1885                 1890             


Val Ile  Gly Glu Leu Gly Glu  Asp Gly Trp Ile Arg  Val Gln Trp 
    1895                 1900                 1905             


Asp Thr  Gly Ser Thr Asn Ser  Tyr Arg Met Gly Lys  Glu Gly Lys 
    1910                 1915                 1920             


Tyr Asp  Leu Lys Leu Ala Glu  Leu Pro Ala Ala Ala  Gln Pro Ser 
    1925                 1930                 1935             


Ala Glu  Asp Ser Asp Thr Glu  Asp Asp Ser Glu Ala  Glu Gln Thr 
    1940                 1945                 1950             


Glu Arg  Asn Ile His Pro Thr  Ala Met Met Phe Thr  Ser Thr Ile 
    1955                 1960                 1965             


Asn Leu  Leu Gln Thr Leu Cys  Leu Ser Ala Gly Val  His Ala Glu 
    1970                 1975                 1980             


Ile Met  Gln Ser Glu Ala Thr  Lys Thr Leu Cys Gly  Leu Leu Arg 
    1985                 1990                 1995             


Met Leu  Val Glu Ser Gly Thr  Thr Asp Lys Thr Ser  Ser Pro Asn 
    2000                 2005                 2010             


Arg Leu  Val Tyr Arg Glu Gln  His Arg Ser Trp Cys  Thr Leu Gly 
    2015                 2020                 2025             


Phe Val  Arg Ser Ile Ala Leu  Thr Pro Gln Val Cys  Gly Ala Leu 
    2030                 2035                 2040             


Ser Ser  Pro Gln Trp Ile Thr  Leu Leu Met Lys Val  Val Glu Gly 
    2045                 2050                 2055             


His Ala  Pro Phe Thr Ala Thr  Ser Leu Gln Arg Gln  Ile Leu Ala 
    2060                 2065                 2070             


Val His  Leu Leu Gln Ala Val  Leu Pro Ser Trp Asp  Lys Thr Glu 
    2075                 2080                 2085             


Arg Ala  Arg Asp Met Lys Cys  Leu Val Glu Lys Leu  Phe Asp Phe 
    2090                 2095                 2100             


Leu Gly  Ser Leu Leu Thr Thr  Cys Ser Ser Asp Val  Pro Leu Leu 
    2105                 2110                 2115             


Arg Glu  Ser Thr Leu Arg Arg  Arg Arg Val Arg Pro  Gln Ala Ser 
    2120                 2125                 2130             


Leu Thr  Ala Thr His Ser Ser  Thr Leu Ala Glu Glu  Val Val Ala 
    2135                 2140                 2145             


Leu Leu  Arg Thr Leu His Ser  Leu Thr Gln Trp Asn  Gly Leu Ile 
    2150                 2155                 2160             


Asn Lys  Tyr Ile Asn Ser Gln  Leu Arg Ser Ile Thr  His Ser Phe 
    2165                 2170                 2175             


Val Gly  Arg Pro Ser Glu Gly  Ala Gln Leu Glu Asp  Tyr Phe Pro 
    2180                 2185                 2190             


Asp Ser  Glu Asn Pro Glu Val  Gly Gly Leu Met Ala  Val Leu Ala 
    2195                 2200                 2205             


Val Ile  Gly Gly Ile Asp Gly  Arg Leu Arg Leu Gly  Gly Gln Val 
    2210                 2215                 2220             


Met His  Asp Glu Phe Gly Glu  Gly Thr Val Thr Arg  Ile Thr Pro 
    2225                 2230                 2235             


Lys Gly  Lys Ile Thr Val Gln  Phe Ser Asp Met Arg  Thr Cys Arg 
    2240                 2245                 2250             


Val Cys  Pro Leu Asn Gln Leu  Lys Pro Leu Pro Ala  Val Ala Phe 
    2255                 2260                 2265             


Asn Val  Asn Asn Leu Pro Phe  Thr Glu Pro Met Leu  Ser Val Trp 
    2270                 2275                 2280             


Ala Gln  Leu Val Asn Leu Ala  Gly Ser Lys Leu Glu  Lys His Lys 
    2285                 2290                 2295             


Ile Lys  Lys Ser Thr Lys Gln  Ala Phe Ala Gly Gln  Val Asp Leu 
    2300                 2305                 2310             


Asp Leu  Leu Arg Cys Gln Gln  Leu Lys Leu Tyr Ile  Leu Lys Ala 
    2315                 2320                 2325             


Gly Arg  Ala Leu Leu Ser His  Gln Asp Lys Leu Arg  Gln Ile Leu 
    2330                 2335                 2340             


Ser Gln  Pro Ala Val Gln Glu  Thr Gly Thr Val His  Thr Asp Asp 
    2345                 2350                 2355             


Gly Ala  Val Val Ser Pro Asp  Leu Gly Asp Met Ser  Pro Glu Gly 
    2360                 2365                 2370             


Pro Gln  Pro Pro Met Ile Leu  Leu Gln Gln Leu Leu  Ala Ser Ala 
    2375                 2380                 2385             


Thr Gln  Pro Ser Pro Val Lys  Ala Ile Phe Asp Lys  Gln Glu Leu 
    2390                 2395                 2400             


Glu Ala  Ala Ala Leu Ala Val  Cys Gln Cys Leu Ala  Val Glu Ser 
    2405                 2410                 2415             


Thr His  Pro Ser Ser Pro Gly  Phe Glu Asp Cys Ser  Ser Ser Glu 
    2420                 2425                 2430             


Ala Thr  Thr Pro Val Ala Val  Gln His Ile Arg Pro  Ala Arg Val 
    2435                 2440                 2445             


Lys Arg  Arg Lys Gln Ser Pro  Val Pro Ala Leu Pro  Ile Val Val 
    2450                 2455                 2460             


Gln Leu  Met Glu Met Gly Phe  Ser Arg Arg Asn Ile  Glu Phe Ala 
    2465                 2470                 2475             


Leu Lys  Ser Leu Thr Gly Ala  Ser Gly Asn Ala Ser  Ser Leu Pro 
    2480                 2485                 2490             


Gly Val  Glu Ala Leu Val Gly  Trp Leu Leu Asp His  Ser Asp Ile 
    2495                 2500                 2505             


Gln Val  Thr Glu Leu Ser Asp  Ala Asp Thr Val Ser  Asp Glu Tyr 
    2510                 2515                 2520             


Ser Asp  Glu Glu Val Val Glu  Asp Val Asp Asp Ala  Ala Tyr Ser 
    2525                 2530                 2535             


Met Ser  Thr Gly Ala Val Val  Thr Glu Ser Gln Thr  Tyr Lys Lys 
    2540                 2545                 2550             


Arg Ala  Asp Phe Leu Ser Asn  Asp Asp Tyr Ala Val  Tyr Val Arg 
    2555                 2560                 2565             


Glu Asn  Ile Gln Val Gly Met  Met Val Arg Cys Cys  Arg Ala Tyr 
    2570                 2575                 2580             


Glu Glu  Val Cys Glu Gly Asp  Val Gly Lys Val Ile  Lys Leu Asp 
    2585                 2590                 2595             


Arg Asp  Gly Leu His Asp Leu  Asn Val Gln Cys Asp  Trp Gln Gln 
    2600                 2605                 2610             


Lys Gly  Gly Thr Tyr Trp Val  Arg Tyr Ile His Val  Glu Leu Ile 
    2615                 2620                 2625             


Gly Tyr  Pro Pro Pro Ser Ser  Ser Ser His Ile Lys  Ile Gly Asp 
    2630                 2635                 2640             


Lys Val  Arg Val Lys Ala Ser  Val Thr Thr Pro Lys  Tyr Lys Trp 
    2645                 2650                 2655             


Gly Ser  Val Thr His Gln Ser  Val Gly Val Val Lys  Ala Phe Ser 
    2660                 2665                 2670             


Ala Asn  Gly Lys Asp Ile Ile  Val Asp Phe Pro Gln  Gln Ser His 
    2675                 2680                 2685             


Trp Thr  Gly Leu Leu Ser Glu  Met Glu Leu Val Pro  Ser Ile His 
    2690                 2695                 2700             


Pro Gly  Val Thr Cys Asp Gly  Cys Gln Met Phe Pro  Ile Asn Gly 
    2705                 2710                 2715             


Ser Arg  Phe Lys Cys Arg Asn  Cys Asp Asp Phe Asp  Phe Cys Glu 
    2720                 2725                 2730             


Thr Cys  Phe Lys Thr Lys Lys  His Asn Thr Arg His  Thr Phe Gly 
    2735                 2740                 2745             


Arg Ile  Asn Glu Pro Gly Gln  Ser Ala Val Phe Cys  Gly Arg Ser 
    2750                 2755                 2760             


Gly Lys  Gln Leu Lys Arg Cys  His Ser Ser Gln Pro  Gly Met Leu 
    2765                 2770                 2775             


Leu Asp  Ser Trp Ser Arg Met  Val Lys Ser Leu Asn  Val Ser Ser 
    2780                 2785                 2790             


Ser Val  Asn Gln Ala Ser Arg  Leu Ile Asp Gly Ser  Glu Pro Cys 
    2795                 2800                 2805             


Trp Gln  Ser Ser Gly Ser Gln  Gly Lys His Trp Ile  Arg Leu Glu 
    2810                 2815                 2820             


Ile Phe  Pro Asp Val Leu Val  His Arg Leu Lys Met  Ile Val Asp 
    2825                 2830                 2835             


Pro Ala  Asp Ser Ser Tyr Met  Pro Ser Leu Val Val  Val Ser Gly 
    2840                 2845                 2850             


Gly Asn  Ser Leu Asn Asn Leu  Ile Glu Leu Lys Thr  Ile Asn Ile 
    2855                 2860                 2865             


Asn Pro  Ser Asp Thr Thr Val  Pro Leu Leu Asn Asp  Cys Thr Glu 
    2870                 2875                 2880             


Tyr His  Arg Tyr Ile Glu Ile  Ala Ile Lys Gln Cys  Arg Ser Ser 
    2885                 2890                 2895             


Gly Ile  Asp Cys Lys Ile His  Gly Leu Ile Leu Leu  Gly Arg Ile 
    2900                 2905                 2910             


Arg Ala  Glu Glu Glu Asp Leu  Ala Ala Val Pro Phe  Leu Ala Ser 
    2915                 2920                 2925             


Asp Asn  Glu Glu Glu Glu Asp  Glu Lys Gly Asn Ser  Gly Ser Leu 
    2930                 2935                 2940             


Ile Arg  Lys Lys Ala Ala Gly  Leu Glu Ser Ala Ala  Thr Ile Arg 
    2945                 2950                 2955             


Thr Lys  Val Phe Val Trp Gly  Leu Asn Asp Lys Asp  Gln Leu Gly 
    2960                 2965                 2970             


Gly Leu  Lys Gly Ser Lys Ile  Lys Val Pro Ser Phe  Ser Glu Thr 
    2975                 2980                 2985             


Leu Ser  Ala Leu Asn Val Val  Gln Val Ala Gly Gly  Ser Lys Ser 
    2990                 2995                 3000             


Leu Phe  Ala Val Thr Val Glu  Gly Lys Val Tyr Ala  Cys Gly Glu 
    3005                 3010                 3015             


Ala Thr  Asn Gly Arg Leu Gly  Leu Gly Ile Ser Ser  Gly Thr Val 
    3020                 3025                 3030             


Pro Ile  Pro Arg Gln Ile Thr  Ala Leu Ser Ser Tyr  Val Val Lys 
    3035                 3040                 3045             


Lys Val  Ala Val His Ser Gly  Gly Arg His Ala Thr  Ala Leu Thr 
    3050                 3055                 3060             


Val Asp  Gly Lys Val Phe Ser  Trp Gly Glu Gly Asp  Asp Gly Lys 
    3065                 3070                 3075             


Leu Gly  His Phe Ser Arg Met  Asn Cys Asp Lys Pro  Arg Leu Ile 
    3080                 3085                 3090             


Glu Ala  Leu Lys Thr Lys Arg  Ile Arg Asp Ile Ala  Cys Gly Ser 
    3095                 3100                 3105             


Ser His  Ser Ala Ala Leu Thr  Ser Ser Gly Glu Leu  Tyr Thr Trp 
    3110                 3115                 3120             


Gly Leu  Gly Glu Tyr Gly Arg  Leu Gly His Gly Asp  Asn Thr Thr 
    3125                 3130                 3135             


Gln Leu  Lys Pro Lys Met Val  Lys Val Leu Leu Gly  His Arg Val 
    3140                 3145                 3150             


Ile Gln  Val Ala Cys Gly Ser  Arg Asp Ala Gln Thr  Leu Ala Leu 
    3155                 3160                 3165             


Thr Asp  Glu Gly Leu Val Phe  Ser Trp Gly Asp Gly  Asp Phe Gly 
    3170                 3175                 3180             


Lys Leu  Gly Arg Gly Gly Ser  Glu Gly Cys Asn Ile  Pro Gln Asn 
    3185                 3190                 3195             


Ile Glu  Arg Leu Asn Gly Gln  Gly Val Cys Gln Ile  Glu Cys Gly 
    3200                 3205                 3210             


Ala Gln  Phe Ser Leu Ala Leu  Thr Lys Ser Gly Val  Val Trp Thr 
    3215                 3220                 3225             


Trp Gly  Lys Gly Asp Tyr Phe  Arg Leu Gly His Gly  Ser Asp Val 
    3230                 3235                 3240             


His Val  Arg Lys Pro Gln Val  Val Glu Gly Leu Arg  Gly Lys Lys 
    3245                 3250                 3255             


Ile Val  His Val Ala Val Gly  Ala Leu His Cys Leu  Ala Val Thr 
    3260                 3265                 3270             


Asp Ser  Gly Gln Val Tyr Ala  Trp Gly Asp Asn Asp  His Gly Gln 
    3275                 3280                 3285             


Gln Gly  Asn Gly Thr Thr Thr  Val Asn Arg Lys Pro  Thr Leu Val 
    3290                 3295                 3300             


Gln Gly  Leu Glu Gly Gln Lys  Ile Thr Arg Val Ala  Cys Gly Ser 
    3305                 3310                 3315             


Ser His  Ser Val Ala Trp Thr  Thr Val Asp Val Ala  Thr Pro Ser 
    3320                 3325                 3330             


Val His  Glu Pro Val Leu Phe  Gln Thr Ala Arg Asp  Pro Leu Gly 
    3335                 3340                 3345             


Ala Ser  Tyr Leu Gly Val Pro  Ser Asp Ala Asp Ser  Ser Ala Ala 
    3350                 3355                 3360             


Ser Asn  Lys Ile Ser Gly Ala  Ser Asn Ser Lys Pro  Asn Arg Pro 
    3365                 3370                 3375             


Ser Leu  Ala Lys Ile Leu Leu  Ser Leu Asp Gly Asn  Leu Ala Lys 
    3380                 3385                 3390             


Gln Gln  Ala Leu Ser His Ile  Leu Thr Ala Leu Gln  Ile Met Tyr 
    3395                 3400                 3405             


Ala Arg  Asp Ala Val Val Gly  Ala Leu Met Pro Ala  Ala Met Ile 
    3410                 3415                 3420             


Ala Pro  Val Glu Cys Pro Ser  Phe Ser Ser Ala Ala  Pro Ser Asp 
    3425                 3430                 3435             


Ala Ser  Ala Met Ala Ser Pro  Met Asn Gly Glu Glu  Cys Met Leu 
    3440                 3445                 3450             


Ala Val  Asp Ile Glu Asp Arg  Leu Ser Pro Asn Pro  Trp Gln Glu 
    3455                 3460                 3465             


Lys Arg  Glu Ile Val Ser Ser  Glu Asp Ala Val Thr  Pro Ser Ala 
    3470                 3475                 3480             


Val Thr  Pro Ser Ala Pro Ser  Ala Ser Ala Arg Pro  Phe Ile Pro 
    3485                 3490                 3495             


Val Thr  Asp Asp Leu Gly Ala  Ala Ser Ile Ile Ala  Glu Thr Met 
    3500                 3505                 3510             


Thr Lys  Thr Lys Glu Asp Val  Glu Ser Gln Asn Lys  Ala Ala Gly 
    3515                 3520                 3525             


Pro Glu  Pro Gln Ala Leu Asp  Glu Phe Thr Ser Leu  Leu Ile Ala 
    3530                 3535                 3540             


Asp Asp  Thr Arg Val Val Val  Asp Leu Leu Lys Leu  Ser Val Cys 
    3545                 3550                 3555             


Ser Arg  Ala Gly Asp Arg Gly  Arg Asp Val Leu Ser  Ala Val Leu 
    3560                 3565                 3570             


Ser Gly  Met Gly Thr Ala Tyr  Pro Gln Val Ala Asp  Met Leu Leu 
    3575                 3580                 3585             


Glu Leu  Cys Val Thr Glu Leu  Glu Asp Val Ala Thr  Asp Ser Gln 
    3590                 3595                 3600             


Ser Gly  Arg Leu Ser Ser Gln  Pro Val Val Val Glu  Ser Ser His 
    3605                 3610                 3615             


Pro Tyr  Thr Asp Asp Thr Ser  Thr Ser Gly Thr Val  Lys Ile Pro 
    3620                 3625                 3630             


Gly Ala  Glu Gly Leu Arg Val  Glu Phe Asp Arg Gln  Cys Ser Thr 
    3635                 3640                 3645             


Glu Arg  Arg His Asp Pro Leu  Thr Val Met Asp Gly  Val Asn Arg 
    3650                 3655                 3660             


Ile Val  Ser Val Arg Ser Gly  Arg Glu Trp Ser Asp  Trp Ser Ser 
    3665                 3670                 3675             


Glu Leu  Arg Ile Pro Gly Asp  Glu Leu Lys Trp Lys  Phe Ile Ser 
    3680                 3685                 3690             


Asp Gly  Ser Val Asn Gly Trp  Gly Trp Arg Phe Thr  Val Tyr Pro 
    3695                 3700                 3705             


Ile Met  Pro Ala Ala Gly Pro  Lys Glu Leu Leu Ser  Asp Arg Cys 
    3710                 3715                 3720             


Val Leu  Ser Cys Pro Ser Met  Asp Leu Val Thr Cys  Leu Leu Asp 
    3725                 3730                 3735             


Phe Arg  Leu Asn Leu Ala Ser  Asn Arg Ser Ile Val  Pro Arg Leu 
    3740                 3745                 3750             


Ala Ala  Ser Leu Ala Ala Cys  Ala Gln Leu Ser Ala  Leu Ala Ala 
    3755                 3760                 3765             


Ser His  Arg Met Trp Ala Leu  Gln Arg Leu Arg Lys  Leu Leu Thr 
    3770                 3775                 3780             


Thr Glu  Phe Gly Gln Ser Ile  Asn Ile Asn Arg Leu  Leu Gly Glu 
    3785                 3790                 3795             


Asn Asp  Gly Glu Thr Arg Ala  Leu Ser Phe Thr Gly  Ser Ala Leu 
    3800                 3805                 3810             


Ala Ala  Leu Val Lys Gly Leu  Pro Glu Ala Leu Gln  Arg Gln Phe 
    3815                 3820                 3825             


Glu Tyr  Glu Asp Pro Ile Val  Arg Gly Gly Lys Gln  Leu Leu His 
    3830                 3835                 3840             


Ser Pro  Phe Phe Lys Val Leu  Val Ala Leu Ala Cys  Asp Leu Glu 
    3845                 3850                 3855             


Leu Asp  Thr Leu Pro Cys Cys  Ala Glu Thr His Lys  Trp Ala Trp 
    3860                 3865                 3870             


Phe Arg  Arg Tyr Cys Met Ala  Ser Arg Val Ala Val  Ala Leu Asp 
    3875                 3880                 3885             


Lys Arg  Thr Pro Leu Pro Arg  Leu Phe Leu Asp Glu  Val Ala Lys 
    3890                 3895                 3900             


Lys Ile  Arg Glu Leu Met Ala  Asp Ser Glu Asn Met  Asp Val Leu 
    3905                 3910                 3915             


His Glu  Ser His Asp Ile Phe  Lys Arg Glu Gln Asp  Glu Gln Leu 
    3920                 3925                 3930             


Val Gln  Trp Met Asn Arg Arg  Pro Asp Asp Trp Thr  Leu Ser Ala 
    3935                 3940                 3945             


Gly Gly  Ser Gly Thr Ile Tyr  Gly Trp Gly His Asn  His Arg Gly 
    3950                 3955                 3960             


Gln Leu  Gly Gly Ile Glu Gly  Ala Lys Val Lys Val  Pro Thr Pro 
    3965                 3970                 3975             


Cys Glu  Ala Leu Ala Thr Leu  Arg Pro Val Gln Leu  Ile Gly Gly 
    3980                 3985                 3990             


Glu Gln  Thr Leu Phe Ala Val  Thr Ala Asp Gly Lys  Leu Tyr Ala 
    3995                 4000                 4005             


Thr Gly  Tyr Gly Ala Gly Gly  Arg Leu Gly Ile Gly  Gly Thr Glu 
    4010                 4015                 4020             


Ser Val  Ser Thr Pro Thr Leu  Leu Glu Ser Ile Gln  His Val Phe 
    4025                 4030                 4035             


Ile Lys  Lys Val Ala Val Asn  Ser Gly Gly Lys His  Cys Leu Ala 
    4040                 4045                 4050             


Leu Ser  Ser Glu Gly Glu Val  Tyr Ser Trp Gly Glu  Ala Glu Asp 
    4055                 4060                 4065             


Gly Lys  Leu Gly His Gly Asn  Arg Ser Pro Cys Asp  Arg Pro Arg 
    4070                 4075                 4080             


Val Ile  Glu Ser Leu Arg Gly  Ile Glu Val Val Asp  Val Ala Ala 
    4085                 4090                 4095             


Gly Gly  Ala His Ser Ala Cys  Val Thr Ala Ala Gly  Asp Leu Tyr 
    4100                 4105                 4110             


Thr Trp  Gly Lys Gly Arg Tyr  Gly Arg Leu Gly His  Ser Asp Ser 
    4115                 4120                 4125             


Glu Asp  Gln Leu Lys Pro Lys  Leu Val Glu Ala Leu  Gln Gly His 
    4130                 4135                 4140             


Arg Val  Val Asp Ile Ala Cys  Gly Ser Gly Asp Ala  Gln Thr Leu 
    4145                 4150                 4155             


Cys Leu  Thr Asp Asp Asp Thr  Val Trp Ser Trp Gly  Asp Gly Asp 
    4160                 4165                 4170             


Tyr Gly  Lys Leu Gly Arg Gly  Gly Ser Asp Gly Cys  Lys Val Pro 
    4175                 4180                 4185             


Met Lys  Ile Asp Ser Leu Thr  Gly Leu Gly Val Val  Lys Val Glu 
    4190                 4195                 4200             


Cys Gly  Ser Gln Phe Ser Val  Ala Leu Thr Lys Ser  Gly Ala Val 
    4205                 4210                 4215             


Tyr Thr  Trp Gly Lys Gly Asp  Tyr His Arg Leu Gly  His Gly Ser 
    4220                 4225                 4230             


Asp Asp  His Val Arg Arg Pro  Arg Gln Val Gln Gly  Leu Gln Gly 
    4235                 4240                 4245             


Lys Lys  Val Ile Ala Ile Ala  Thr Gly Ser Leu His  Cys Val Cys 
    4250                 4255                 4260             


Cys Thr  Glu Asp Gly Glu Val  Tyr Thr Trp Gly Asp  Asn Asp Glu 
    4265                 4270                 4275             


Gly Gln  Leu Gly Asp Gly Thr  Thr Asn Ala Ile Gln  Arg Pro Arg 
    4280                 4285                 4290             


Leu Val  Ala Ala Leu Gln Gly  Lys Lys Val Asn Arg  Val Ala Cys 
    4295                 4300                 4305             


Gly Ser  Ala His Thr Leu Ala  Trp Ser Thr Ser Lys  Pro Ala Ser 
    4310                 4315                 4320             


Ala Gly  Lys Leu Pro Ala Gln  Val Pro Met Glu Tyr  Asn His Leu 
    4325                 4330                 4335             


Gln Glu  Ile Pro Ile Ile Ala  Leu Arg Asn Arg Leu  Leu Leu Leu 
    4340                 4345                 4350             


His His  Leu Ser Glu Leu Phe  Cys Pro Cys Ile Pro  Met Phe Asp 
    4355                 4360                 4365             


Leu Glu  Gly Ser Leu Asp Glu  Thr Gly Leu Gly Pro  Ser Val Gly 
    4370                 4375                 4380             


Phe Asp  Thr Leu Arg Gly Ile  Leu Ile Ser Gln Gly  Lys Glu Ala 
    4385                 4390                 4395             


Ala Phe  Arg Lys Val Val Gln  Ala Thr Met Val Arg  Asp Arg Gln 
    4400                 4405                 4410             


His Gly  Pro Val Val Glu Leu  Asn Arg Ile Gln Val  Lys Arg Ser 
    4415                 4420                 4425             


Arg Ser  Lys Gly Gly Leu Ala  Gly Pro Asp Gly Thr  Lys Ser Val 
    4430                 4435                 4440             


Phe Gly  Gln Met Cys Ala Lys  Met Ser Ser Phe Gly  Pro Asp Ser 
    4445                 4450                 4455             


Leu Leu  Leu Pro His Arg Val  Trp Lys Val Lys Phe  Val Gly Glu 
    4460                 4465                 4470             


Ser Val  Asp Asp Cys Gly Gly  Gly Tyr Ser Glu Ser  Ile Ala Glu 
    4475                 4480                 4485             


Ile Cys  Glu Glu Leu Gln Asn  Gly Leu Thr Pro Leu  Leu Ile Val 
    4490                 4495                 4500             


Thr Pro  Asn Gly Arg Asp Glu  Ser Gly Ala Asn Arg  Asp Cys Tyr 
    4505                 4510                 4515             


Leu Leu  Ser Pro Ala Ala Arg  Ala Pro Val His Ser  Ser Met Phe 
    4520                 4525                 4530             


Arg Phe  Leu Gly Val Leu Leu  Gly Ile Ala Ile Arg  Thr Gly Ser 
    4535                 4540                 4545             


Pro Leu  Ser Leu Asn Leu Ala  Glu Pro Val Trp Lys  Gln Leu Ala 
    4550                 4555                 4560             


Gly Met  Ser Leu Thr Ile Ala  Asp Leu Ser Glu Val  Asp Lys Asp 
    4565                 4570                 4575             


Phe Ile  Pro Gly Leu Met Tyr  Ile Arg Asp Asn Glu  Ala Thr Ser 
    4580                 4585                 4590             


Glu Glu  Phe Glu Ala Met Ser  Leu Pro Phe Thr Val  Pro Ser Ala 
    4595                 4600                 4605             


Ser Gly  Gln Asp Ile Gln Leu  Ser Ser Lys His Thr  His Ile Thr 
    4610                 4615                 4620             


Leu Asp  Asn Arg Ala Glu Tyr  Val Arg Leu Ala Ile  Asn Tyr Arg 
    4625                 4630                 4635             


Leu His  Glu Phe Asp Glu Gln  Val Ala Ala Val Arg  Glu Gly Met 
    4640                 4645                 4650             


Ala Arg  Val Val Pro Val Pro  Leu Leu Ser Leu Phe  Thr Gly Tyr 
    4655                 4660                 4665             


Glu Leu  Glu Thr Met Val Cys  Gly Ser Pro Asp Ile  Pro Leu His 
    4670                 4675                 4680             


Leu Leu  Lys Ser Val Ala Thr  Tyr Lys Gly Ile Glu  Pro Ser Ala 
    4685                 4690                 4695             


Ser Leu  Ile Gln Trp Phe Trp  Glu Val Met Glu Ser  Phe Ser Asn 
    4700                 4705                 4710             


Thr Glu  Arg Ser Leu Phe Leu  Arg Phe Val Trp Gly  Arg Thr Arg 
    4715                 4720                 4725             


Leu Pro  Arg Thr Ile Ala Asp  Phe Arg Gly Arg Asp  Phe Val Ile 
    4730                 4735                 4740             


Gln Val  Leu Asp Lys Tyr Asn  Pro Pro Asp His Phe  Leu Pro Glu 
    4745                 4750                 4755             


Ser Tyr  Thr Cys Phe Phe Leu  Leu Lys Leu Pro Arg  Tyr Ser Cys 
    4760                 4765                 4770             


Lys Gln  Val Leu Glu Glu Lys  Leu Lys Tyr Ala Ile  His Phe Cys 
    4775                 4780                 4785             


Lys Ser  Ile Asp Thr Asp Asp  Tyr Ala Arg Ile Ala  Leu Thr Gly 
    4790                 4795                 4800             


Glu Pro  Ala Ala Asp Asp Ser  Ser Asp Asp Ser Asp  Asn Glu Asp 
    4805                 4810                 4815             


Val Asp  Ser Phe Ala Ser Asp  Ser Thr Gln Asp Tyr  Leu Thr Gly 
    4820                 4825                 4830             


His 
    


<210>  4942
<211>  932
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HERC3__Homo_sapiens__NP_001258531

<400>  4942

Met Thr Thr Glu Asp Ser Val Ala Val Pro Arg Leu Ile Gln Lys Leu 
1               5                   10                  15      


Asn Gln Gln Thr Ile Leu Gln Val Ser Cys Gly Asn Trp His Cys Leu 
            20                  25                  30          


Ala Leu Ala Ala Asp Gly Gln Phe Phe Thr Trp Gly Lys Asn Ser His 
        35                  40                  45              


Gly Gln Leu Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln 
    50                  55                  60                  


Arg Val Arg Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly 
65                  70                  75                  80  


Gly Ala His Ser Phe Ala Leu Ser Leu Ser Gly Ala Val Phe Gly Trp 
                85                  90                  95      


Gly Met Asn Asn Ala Gly Gln Leu Gly Leu Ser Asp Glu Lys Asp Arg 
            100                 105                 110         


Glu Ser Pro Cys His Val Lys Leu Leu Arg Thr Gln Lys Val Val Tyr 
        115                 120                 125             


Ile Ser Cys Gly Glu Glu His Thr Ala Val Leu Thr Lys Ser Gly Gly 
    130                 135                 140                 


Val Phe Thr Phe Gly Ala Gly Ser Cys Gly Gln Leu Gly His Asp Ser 
145                 150                 155                 160 


Met Asn Asp Glu Val Asn Pro Arg Arg Val Leu Glu Leu Met Gly Ser 
                165                 170                 175     


Glu Val Thr Gln Ile Ala Cys Gly Arg Gln His Thr Leu Ala Phe Val 
            180                 185                 190         


Pro Ser Ser Gly Leu Ile Tyr Ala Phe Gly Cys Gly Ala Arg Gly Gln 
        195                 200                 205             


Leu Gly Thr Gly His Thr Cys Asn Val Lys Cys Pro Ser Pro Val Lys 
    210                 215                 220                 


Gly Tyr Trp Ala Ala His Ser Gly Gln Leu Ser Ala Arg Ala Asp Arg 
225                 230                 235                 240 


Phe Lys Tyr His Ile Val Lys Gln Ile Phe Ser Gly Gly Asp Gln Thr 
                245                 250                 255     


Phe Val Leu Cys Ser Lys Tyr Glu Asn Tyr Ser Pro Ala Val Asp Phe 
            260                 265                 270         


Arg Thr Met Asn Gln Ala His Tyr Thr Ser Leu Ile Asn Asp Glu Thr 
        275                 280                 285             


Ile Ala Val Trp Arg Gln Lys Leu Ser Glu His Asn Asn Ala Asn Thr 
    290                 295                 300                 


Ile Asn Gly Val Val Gln Ile Leu Ser Ser Ala Ala Cys Trp Asn Gly 
305                 310                 315                 320 


Ser Phe Leu Glu Lys Lys Ile Asp Glu His Phe Lys Thr Ser Pro Lys 
                325                 330                 335     


Ile Pro Gly Ile Asp Leu Asn Ser Thr Arg Val Leu Phe Glu Lys Leu 
            340                 345                 350         


Met Asn Ser Gln His Ser Met Ile Leu Glu Gln Ile Leu Asn Ser Phe 
        355                 360                 365             


Glu Ser Cys Leu Ile Pro Gln Leu Ser Ser Ser Pro Pro Asp Val Glu 
    370                 375                 380                 


Ala Met Arg Ile Tyr Leu Ile Leu Pro Glu Phe Pro Leu Leu Gln Asp 
385                 390                 395                 400 


Ser Lys Tyr Tyr Ile Thr Leu Thr Ile Pro Leu Ala Met Ala Ile Leu 
                405                 410                 415     


Arg Leu Asp Thr Asn Pro Ser Lys Val Leu Asp Asn Trp Trp Ser Gln 
            420                 425                 430         


Val Cys Pro Lys Tyr Phe Met Lys Leu Val Asn Leu Tyr Lys Gly Ala 
        435                 440                 445             


Val Leu Tyr Leu Leu Arg Gly Arg Lys Thr Phe Leu Ile Pro Val Leu 
    450                 455                 460                 


Phe Asn Asn Tyr Ile Thr Ala Ala Leu Lys Leu Leu Glu Lys Leu Tyr 
465                 470                 475                 480 


Lys Val Asn Leu Lys Val Lys His Val Glu Tyr Asp Thr Phe Tyr Ile 
                485                 490                 495     


Pro Glu Ile Ser Asn Leu Val Asp Ile Gln Glu Asp Tyr Leu Met Trp 
            500                 505                 510         


Phe Leu His Gln Ala Gly Met Lys Ala Arg Pro Ser Ile Ile Gln Asp 
        515                 520                 525             


Thr Val Thr Leu Cys Ser Tyr Pro Phe Ile Phe Asp Ala Gln Ala Lys 
    530                 535                 540                 


Thr Lys Met Leu Gln Thr Asp Ala Glu Leu Gln Met Gln Val Ala Val 
545                 550                 555                 560 


Asn Gly Ala Asn Leu Gln Asn Val Phe Met Leu Leu Thr Leu Glu Pro 
                565                 570                 575     


Leu Leu Ala Arg Ser Pro Phe Leu Val Leu His Val Arg Arg Asn Asn 
            580                 585                 590         


Leu Val Gly Asp Ala Leu Arg Glu Leu Ser Ile His Ser Asp Ile Asp 
        595                 600                 605             


Leu Lys Lys Pro Leu Lys Val Ile Phe Asp Gly Glu Glu Ala Val Asp 
    610                 615                 620                 


Ala Gly Gly Val Thr Lys Glu Phe Phe Leu Leu Leu Leu Lys Glu Leu 
625                 630                 635                 640 


Leu Asn Pro Ile Tyr Gly Met Phe Thr Tyr Tyr Gln Asp Ser Asn Leu 
                645                 650                 655     


Leu Trp Phe Ser Asp Thr Cys Phe Val Glu His Asn Trp Phe His Leu 
            660                 665                 670         


Ile Gly Ile Thr Cys Gly Leu Ala Ile Tyr Asn Ser Thr Val Val Asp 
        675                 680                 685             


Leu His Phe Pro Leu Ala Leu Tyr Lys Lys Leu Leu Asn Val Lys Pro 
    690                 695                 700                 


Gly Leu Glu Asp Leu Lys Glu Leu Ser Pro Thr Glu Gly Arg Ser Leu 
705                 710                 715                 720 


Gln Glu Leu Leu Asp Tyr Pro Gly Glu Asp Val Glu Glu Thr Phe Cys 
                725                 730                 735     


Leu Asn Phe Thr Ile Cys Arg Glu Ser Tyr Gly Val Ile Glu Gln Lys 
            740                 745                 750         


Lys Leu Ile Pro Gly Gly Asp Asn Val Thr Val Cys Lys Asp Asn Arg 
        755                 760                 765             


Gln Glu Phe Val Asp Ala Tyr Val Asn Tyr Val Phe Gln Ile Ser Val 
    770                 775                 780                 


His Glu Trp Tyr Thr Ala Phe Ser Ser Gly Phe Leu Lys Val Cys Gly 
785                 790                 795                 800 


Gly Lys Val Leu Glu Leu Phe Gln Pro Ser Glu Leu Arg Ala Met Met 
                805                 810                 815     


Val Gly Asn Ser Asn Tyr Asn Trp Glu Glu Leu Glu Glu Thr Ala Ile 
            820                 825                 830         


Tyr Lys Gly Asp Tyr Ser Ala Thr His Pro Thr Val Lys Leu Phe Trp 
        835                 840                 845             


Glu Thr Phe His Glu Phe Pro Leu Glu Lys Lys Lys Lys Phe Leu Leu 
    850                 855                 860                 


Phe Leu Thr Gly Ser Asp Arg Ile Pro Ile Tyr Gly Met Ala Ser Leu 
865                 870                 875                 880 


Gln Ile Val Ile Gln Ser Thr Ala Ser Gly Glu Glu Tyr Leu Pro Val 
                885                 890                 895     


Ala His Thr Cys Tyr Asn Leu Leu Asp Leu Pro Lys Tyr Ser Ser Lys 
            900                 905                 910         


Glu Ile Leu Ser Ala Arg Leu Thr Gln Ala Leu Asp Asn Tyr Glu Gly 
        915                 920                 925             


Phe Ser Leu Ala 
    930         


<210>  4943
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HERC5__Homo_sapiens__NP_057407

<400>  4943

Met Glu Arg Arg Ser Arg Arg Lys Ser Arg Arg Asn Gly Arg Ser Thr 
1               5                   10                  15      


Ala Gly Lys Ala Ala Ala Thr Gln Pro Ala Lys Ser Pro Gly Ala Gln 
            20                  25                  30          


Leu Trp Leu Phe Pro Ser Ala Ala Gly Leu His Arg Ala Leu Leu Arg 
        35                  40                  45              


Arg Val Glu Val Thr Arg Gln Leu Cys Cys Ser Pro Gly Arg Leu Ala 
    50                  55                  60                  


Val Leu Glu Arg Gly Gly Ala Gly Val Gln Val His Gln Leu Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Gly Ala Arg Thr Pro Lys Cys Ile Lys Leu Gly Lys Asn 
                85                  90                  95      


Met Lys Ile His Ser Val Asp Gln Gly Ala Glu His Met Leu Ile Leu 
            100                 105                 110         


Ser Ser Asp Gly Lys Pro Phe Glu Tyr Asp Asn Tyr Ser Met Lys His 
        115                 120                 125             


Leu Arg Phe Glu Ser Ile Leu Gln Glu Lys Lys Ile Ile Gln Ile Thr 
    130                 135                 140                 


Cys Gly Asp Tyr His Ser Leu Ala Leu Ser Lys Gly Gly Glu Leu Phe 
145                 150                 155                 160 


Ala Trp Gly Gln Asn Leu His Gly Gln Leu Gly Val Gly Arg Lys Phe 
                165                 170                 175     


Pro Ser Thr Thr Thr Pro Gln Ile Val Glu His Leu Ala Gly Val Pro 
            180                 185                 190         


Leu Ala Gln Ile Ser Ala Gly Glu Ala His Ser Met Ala Leu Ser Met 
        195                 200                 205             


Ser Gly Asn Ile Tyr Ser Trp Gly Lys Asn Glu Cys Gly Gln Leu Gly 
    210                 215                 220                 


Leu Gly His Thr Glu Ser Lys Asp Asp Pro Ser Leu Ile Glu Gly Leu 
225                 230                 235                 240 


Asp Asn Gln Lys Val Glu Phe Val Ala Cys Gly Gly Ser His Ser Ala 
                245                 250                 255     


Leu Leu Thr Gln Asp Gly Leu Leu Phe Thr Phe Gly Ala Gly Lys His 
            260                 265                 270         


Gly Gln Leu Gly His Asn Ser Thr Gln Asn Glu Leu Arg Pro Cys Leu 
        275                 280                 285             


Val Ala Glu Leu Val Gly Tyr Arg Val Thr Gln Ile Ala Cys Gly Arg 
    290                 295                 300                 


Trp His Thr Leu Ala Tyr Val Ser Asp Leu Gly Lys Val Phe Ser Phe 
305                 310                 315                 320 


Gly Ser Gly Lys Asp Gly Gln Leu Gly Asn Gly Gly Thr Arg Asp Gln 
                325                 330                 335     


Leu Met Pro Leu Pro Val Lys Val Ser Ser Ser Glu Glu Leu Lys Leu 
            340                 345                 350         


Glu Ser His Thr Ser Glu Lys Glu Leu Ile Met Ile Ala Gly Gly Asn 
        355                 360                 365             


Gln Ser Ile Leu Leu Trp Ile Lys Lys Glu Asn Ser Tyr Val Asn Leu 
    370                 375                 380                 


Lys Arg Thr Ile Pro Thr Leu Asn Glu Gly Thr Val Lys Arg Trp Ile 
385                 390                 395                 400 


Ala Asp Val Glu Thr Lys Arg Trp Gln Ser Thr Lys Arg Glu Ile Gln 
                405                 410                 415     


Glu Ile Phe Ser Ser Pro Ala Cys Leu Thr Gly Ser Phe Leu Arg Lys 
            420                 425                 430         


Arg Arg Thr Thr Glu Met Met Pro Val Tyr Leu Asp Leu Asn Lys Ala 
        435                 440                 445             


Arg Asn Ile Phe Lys Glu Leu Thr Gln Lys Asp Trp Ile Thr Asn Met 
    450                 455                 460                 


Ile Thr Thr Cys Leu Lys Asp Asn Leu Leu Lys Arg Leu Pro Phe His 
465                 470                 475                 480 


Ser Pro Pro Gln Glu Ala Leu Glu Ile Phe Phe Leu Leu Pro Glu Cys 
                485                 490                 495     


Pro Met Met His Ile Ser Asn Asn Trp Glu Ser Leu Val Val Pro Phe 
            500                 505                 510         


Ala Lys Val Val Cys Lys Met Ser Asp Gln Ser Ser Leu Val Leu Glu 
        515                 520                 525             


Glu Tyr Trp Ala Thr Leu Gln Glu Ser Thr Phe Ser Lys Leu Val Gln 
    530                 535                 540                 


Met Phe Lys Thr Ala Val Ile Cys Gln Leu Asp Tyr Trp Asp Glu Ser 
545                 550                 555                 560 


Ala Glu Glu Asn Gly Asn Val Gln Ala Leu Leu Glu Met Leu Lys Lys 
                565                 570                 575     


Leu His Arg Val Asn Gln Val Lys Cys Gln Leu Pro Glu Ser Ile Phe 
            580                 585                 590         


Gln Val Asp Glu Leu Leu His Arg Leu Asn Phe Phe Val Glu Val Cys 
        595                 600                 605             


Arg Arg Tyr Leu Trp Lys Met Thr Val Asp Ala Ser Glu Asn Val Gln 
    610                 615                 620                 


Cys Cys Val Ile Phe Ser His Phe Pro Phe Ile Phe Asn Asn Leu Ser 
625                 630                 635                 640 


Lys Ile Lys Leu Leu His Thr Asp Thr Leu Leu Lys Ile Glu Ser Lys 
                645                 650                 655     


Lys His Lys Ala Tyr Leu Arg Ser Ala Ala Ile Glu Glu Glu Arg Glu 
            660                 665                 670         


Ser Glu Phe Ala Leu Arg Pro Thr Phe Asp Leu Thr Val Arg Arg Asn 
        675                 680                 685             


His Leu Ile Glu Asp Val Leu Asn Gln Leu Ser Gln Phe Glu Asn Glu 
    690                 695                 700                 


Asp Leu Arg Lys Glu Leu Trp Val Ser Phe Ser Gly Glu Ile Gly Tyr 
705                 710                 715                 720 


Asp Leu Gly Gly Val Lys Lys Glu Phe Phe Tyr Cys Leu Phe Ala Glu 
                725                 730                 735     


Met Ile Gln Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu Gly Ala Ser 
            740                 745                 750         


Cys Met Trp Phe Pro Val Lys Pro Lys Phe Glu Lys Lys Arg Tyr Phe 
        755                 760                 765             


Phe Phe Gly Val Leu Cys Gly Leu Ser Leu Phe Asn Cys Asn Val Ala 
    770                 775                 780                 


Asn Leu Pro Phe Pro Leu Ala Leu Phe Lys Lys Leu Leu Asp Gln Met 
785                 790                 795                 800 


Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Asp Leu Gly Lys Asn 
                805                 810                 815     


Leu Gln Thr Leu Leu Asp Asp Glu Gly Asp Asn Phe Glu Glu Val Phe 
            820                 825                 830         


Tyr Ile His Phe Asn Val His Trp Asp Arg Asn Asp Thr Asn Leu Ile 
        835                 840                 845             


Pro Asn Gly Ser Ser Ile Thr Val Asn Gln Thr Asn Lys Arg Asp Tyr 
    850                 855                 860                 


Val Ser Lys Tyr Ile Asn Tyr Ile Phe Asn Asp Ser Val Lys Ala Val 
865                 870                 875                 880 


Tyr Glu Glu Phe Arg Arg Gly Phe Tyr Lys Met Cys Asp Glu Asp Ile 
                885                 890                 895     


Ile Lys Leu Phe His Pro Glu Glu Leu Lys Asp Val Ile Val Gly Asn 
            900                 905                 910         


Thr Asp Tyr Asp Trp Lys Thr Phe Glu Lys Asn Ala Arg Tyr Glu Pro 
        915                 920                 925             


Gly Tyr Asn Ser Ser His Pro Thr Ile Val Met Phe Trp Lys Ala Phe 
    930                 935                 940                 


His Lys Leu Thr Leu Glu Glu Lys Lys Lys Phe Leu Val Phe Leu Thr 
945                 950                 955                 960 


Gly Thr Asp Arg Leu Gln Met Lys Asp Leu Asn Asn Met Lys Ile Thr 
                965                 970                 975     


Phe Cys Cys Pro Glu Ser Trp Asn Glu Arg Asp Pro Ile Arg Ala Leu 
            980                 985                 990         


Thr Cys Phe Ser Val Leu Phe Leu  Pro Lys Tyr Ser Thr  Met Glu Thr 
        995                 1000                 1005             


Val Glu  Glu Ala Leu Gln Glu  Ala Ile Asn Asn Asn  Arg Gly Phe 
    1010                 1015                 1020             


Gly 
    


<210>  4944
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HERC6__Homo_sapiens__NP_001158608

<400>  4944

Met Tyr Phe Cys Trp Gly Ala Asp Ser Arg Glu Leu Gln Arg Arg Arg 
1               5                   10                  15      


Thr Ala Gly Ser Pro Gly Ala Glu Leu Leu Gln Ala Ala Ser Gly Glu 
            20                  25                  30          


Arg His Ser Leu Leu Leu Leu Thr Asn His Arg Val Leu Ser Cys Gly 
        35                  40                  45              


Asp Asn Ser Arg Gly Gln Leu Gly Arg Arg Gly Ala Gln Arg Gly Glu 
    50                  55                  60                  


Leu Pro Glu Pro Ile Gln Ala Leu Glu Thr Leu Ile Val Asp Leu Val 
65                  70                  75                  80  


Ser Cys Gly Lys Glu His Ser Leu Ala Val Cys His Lys Gly Arg Val 
                85                  90                  95      


Phe Ala Trp Gly Ala Gly Ser Glu Gly Gln Leu Gly Ile Gly Glu Phe 
            100                 105                 110         


Lys Glu Ile Ser Phe Thr Pro Lys Lys Ile Met Thr Leu Asn Asp Ile 
        115                 120                 125             


Lys Ile Ile Gln Val Ser Cys Gly His Tyr His Ser Leu Ala Leu Ser 
    130                 135                 140                 


Lys Asp Ser Gln Val Phe Ser Trp Gly Lys Asn Ser His Gly Gln Leu 
145                 150                 155                 160 


Gly Leu Gly Lys Glu Phe Pro Ser Gln Ala Ser Pro Gln Arg Val Arg 
                165                 170                 175     


Ser Leu Glu Gly Ile Pro Leu Ala Gln Val Ala Ala Gly Gly Ala His 
            180                 185                 190         


Ser Phe Ala Leu Ser Leu Cys Gly Thr Ser Phe Gly Trp Gly Ser Asn 
        195                 200                 205             


Ser Ala Gly Gln Leu Ala Leu Ser Gly Arg Asn Val Pro Val Gln Ser 
    210                 215                 220                 


Asn Lys Pro Leu Ser Val Gly Ala Leu Lys Asn Leu Gly Val Val Tyr 
225                 230                 235                 240 


Ile Ser Cys Gly Asp Ala His Thr Ala Val Leu Thr Gln Asp Gly Lys 
                245                 250                 255     


Val Phe Thr Phe Gly Asp Asn Arg Ser Gly Gln Leu Gly Tyr Ser Pro 
            260                 265                 270         


Thr Pro Glu Lys Arg Gly Pro Gln Leu Val Glu Arg Ile Asp Gly Leu 
        275                 280                 285             


Val Ser Gln Ile Asp Cys Gly Ser Tyr His Thr Leu Ala Tyr Val His 
    290                 295                 300                 


Thr Thr Gly Gln Val Val Ser Phe Gly His Gly Pro Ser Asp Thr Ser 
305                 310                 315                 320 


Lys Pro Thr His Pro Glu Ala Leu Thr Glu Asn Phe Asp Ile Ser Cys 
                325                 330                 335     


Leu Ile Ser Ala Glu Asp Phe Val Asp Val Gln Val Lys His Ile Phe 
            340                 345                 350         


Ala Gly Thr Tyr Ala Asn Phe Val Thr Thr His Gln Asp Thr Ser Ser 
        355                 360                 365             


Thr Arg Ala Pro Gly Lys Thr Leu Pro Glu Ile Ser Arg Ile Ser Gln 
    370                 375                 380                 


Ser Met Ala Glu Lys Trp Ile Ala Val Lys Arg Arg Ser Thr Glu His 
385                 390                 395                 400 


Glu Met Ala Lys Ser Glu Ile Arg Met Ile Phe Ser Ser Pro Ala Cys 
                405                 410                 415     


Leu Thr Ala Ser Phe Leu Lys Lys Arg Gly Thr Gly Glu Thr Thr Ser 
            420                 425                 430         


Ile Asp Val Asp Leu Glu Met Ala Arg Asp Thr Phe Lys Lys Leu Thr 
        435                 440                 445             


Lys Lys Glu Trp Ile Ser Ser Met Ile Thr Thr Cys Leu Glu Asp Asp 
    450                 455                 460                 


Leu Leu Arg Ala Leu Pro Cys His Ser Pro His Gln Glu Ala Leu Ser 
465                 470                 475                 480 


Val Phe Leu Leu Leu Pro Glu Cys Pro Val Met His Asp Ser Lys Asn 
                485                 490                 495     


Trp Lys Asn Leu Val Val Pro Phe Ala Lys Ala Val Cys Glu Met Ser 
            500                 505                 510         


Lys Gln Ser Leu Gln Val Leu Lys Lys Cys Trp Ala Phe Leu Gln Glu 
        515                 520                 525             


Ser Ser Leu Asn Pro Leu Ile Gln Met Leu Lys Ala Ala Ile Ile Ser 
    530                 535                 540                 


Gln Leu Leu His Gln Thr Lys Thr Glu Gln Asp His Cys Asn Val Lys 
545                 550                 555                 560 


Ala Leu Leu Gly Met Met Lys Glu Leu His Lys Val Asn Lys Ala Asn 
                565                 570                 575     


Cys Arg Leu Pro Glu Asn Thr Phe Asn Ile Asn Glu Leu Ser Asn Leu 
            580                 585                 590         


Leu Asn Phe Tyr Ile Asp Arg Gly Arg Gln Leu Phe Arg Asp Asn His 
        595                 600                 605             


Leu Met Ser Glu Lys Lys Ala Tyr Met Leu Met His Glu Thr Ile Leu 
    610                 615                 620                 


Gln Lys Lys Asp Glu Phe Pro Pro Ser Pro Arg Phe Ile Leu Arg Val 
625                 630                 635                 640 


Arg Arg Ser Arg Leu Val Lys Asp Ala Leu Arg Gln Leu Ser Gln Ala 
                645                 650                 655     


Glu Ala Thr Asp Phe Cys Lys Val Leu Val Val Glu Phe Ile Asn Glu 
            660                 665                 670         


Ile Cys Pro Glu Ser Gly Gly Val Ser Ser Glu Phe Phe His Cys Met 
        675                 680                 685             


Phe Glu Glu Met Thr Lys Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu 
    690                 695                 700                 


Met Gly Ser Cys Met Trp Phe Pro Ala Lys Pro Lys Pro Glu Lys Lys 
705                 710                 715                 720 


Arg Tyr Phe Leu Phe Gly Met Leu Cys Gly Leu Ser Leu Phe Asn Leu 
                725                 730                 735     


Asn Val Ala Asn Leu Pro Phe Pro Leu Ala Leu Tyr Lys Lys Leu Leu 
            740                 745                 750         


Asp Gln Lys Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Arg Leu 
        755                 760                 765             


Gly Lys Ser Leu Gln Glu Val Leu Asp Asp Ala Ala Asp Asp Ile Gly 
    770                 775                 780                 


Asp Ala Leu Cys Ile Arg Phe Ser Ile His Trp Asp Gln Asn Asp Val 
785                 790                 795                 800 


Asp Leu Ile Pro Asn Gly Ile Ser Ile Pro Val Asp Gln Thr Asn Lys 
                805                 810                 815     


Arg Asp Tyr Val Ser Lys Tyr Ile Asp Tyr Ile Phe Asn Val Ser Val 
            820                 825                 830         


Lys Ala Val Tyr Glu Glu Phe Gln Arg Gly Phe Tyr Arg Val Cys Glu 
        835                 840                 845             


Lys Glu Ile Leu Arg His Phe Tyr Pro Glu Glu Leu Met Thr Ala Ile 
    850                 855                 860                 


Ile Gly Asn Thr Asp Tyr Asp Trp Lys Gln Phe Glu Gln Asn Ser Lys 
865                 870                 875                 880 


Tyr Glu Gln Gly Tyr Gln Lys Ser His Pro Thr Ile Gln Leu Phe Trp 
                885                 890                 895     


Lys Ala Phe His Lys Leu Thr Leu Asp Glu Lys Lys Lys Phe Leu Phe 
            900                 905                 910         


Phe Leu Thr Gly Arg Asp Arg Leu His Ala Arg Gly Ile Gln Lys Met 
        915                 920                 925             


Glu Ile Val Phe Arg Cys Pro Glu Thr Phe Ser Glu Arg Asp His Pro 
    930                 935                 940                 


Thr Ser Ile Thr Cys His Asn Ile Leu Ser Leu Pro Lys Tyr Ser Thr 
945                 950                 955                 960 


Met Glu Arg Met Glu Glu Ala Leu Gln Val Ala Ile Asn Asn Asn Arg 
                965                 970                 975     


Gly Phe Val Ser Pro Met Leu Thr Gln Ser 
            980                 985     


<210>  4945
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HERPUD1__Homo_sapiens__NP_001010989

<400>  4945

Met Glu Ser Glu Thr Glu Pro Glu Pro Val Thr Leu Leu Val Lys Ser 
1               5                   10                  15      


Pro Asn Gln Arg His Arg Asp Leu Glu Leu Ser Gly Asp Arg Gly Trp 
            20                  25                  30          


Ser Val Gly His Leu Lys Ala His Leu Ser Arg Val Tyr Pro Glu Arg 
        35                  40                  45              


Pro Arg Pro Glu Asp Gln Arg Leu Ile Tyr Ser Gly Lys Leu Leu Leu 
    50                  55                  60                  


Asp His Gln Cys Leu Arg Asp Leu Leu Pro Lys Glu Lys Arg His Val 
65                  70                  75                  80  


Leu His Leu Val Cys Asn Val Lys Ser Pro Ser Lys Met Pro Glu Ile 
                85                  90                  95      


Asn Ala Lys Val Ala Glu Ser Thr Glu Glu Pro Ala Gly Ser Asn Arg 
            100                 105                 110         


Gly Gln Tyr Pro Glu Asp Ser Ser Ser Asp Gly Leu Arg Gln Arg Glu 
        115                 120                 125             


Val Leu Arg Asn Leu Ser Ser Pro Gly Trp Glu Asn Ile Ser Arg Pro 
    130                 135                 140                 


Glu Ala Ala Gln Gln Ala Phe Gln Gly Leu Gly Pro Gly Phe Ser Gly 
145                 150                 155                 160 


Tyr Thr Pro Tyr Gly Trp Leu Gln Leu Ser Trp Phe Gln Gln Ile Tyr 
                165                 170                 175     


Ala Arg Gln Tyr Tyr Met Gln Tyr Leu Ala Ala Thr Ala Ala Ser Gly 
            180                 185                 190         


Ala Phe Val Pro Pro Pro Ser Ala Gln Glu Ile Pro Val Val Ser Ala 
        195                 200                 205             


Pro Ala Pro Ala Pro Ile His Asn Gln Phe Pro Ala Glu Asn Gln Pro 
    210                 215                 220                 


Ala Asn Gln Asn Ala Ala Pro Gln Val Val Val Asn Pro Gly Ala Asn 
225                 230                 235                 240 


Gln Asn Leu Arg Met Asn Ala Gln Gly Gly Pro Ile Val Glu Glu Asp 
                245                 250                 255     


Asp Glu Ile Asn Arg Asp Trp Leu Asp Trp Thr Tyr Ser Ala Ala Thr 
            260                 265                 270         


Phe Ser Val Phe Leu Ser Ile Leu Tyr Phe Tyr Ser Ser Leu Ser Arg 
        275                 280                 285             


Phe Leu Met Val Met Gly Ala Thr Val Val Met Tyr Leu His His Val 
    290                 295                 300                 


Gly Trp Phe Pro Phe Arg Pro Arg Pro Val Gln Asn Phe Pro Asn Asp 
305                 310                 315                 320 


Gly Pro Pro Pro Asp Val Val Asn Gln Asp Pro Asn Asn Asn Leu Gln 
                325                 330                 335     


Glu Gly Thr Asp Pro Glu Thr Glu Asp Pro Asn His Leu Pro Pro Asp 
            340                 345                 350         


Arg Asp Val Leu Asp Gly Glu Gln Thr Ser Pro Ser Phe Met Ser Thr 
        355                 360                 365             


Ala Trp Leu Val Phe Lys Thr Phe Phe Ala Ser Leu Leu Pro Glu Gly 
    370                 375                 380                 


Pro Pro Ala Ile Ala Asn 
385                 390 


<210>  4946
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HES1__Homo_sapiens__NP_005515

<400>  4946

Met Pro Ala Asp Ile Met Glu Lys Asn Ser Ser Ser Pro Val Ala Ala 
1               5                   10                  15      


Thr Pro Ala Ser Val Asn Thr Thr Pro Asp Lys Pro Lys Thr Ala Ser 
            20                  25                  30          


Glu His Arg Lys Ser Ser Lys Pro Ile Met Glu Lys Arg Arg Arg Ala 
        35                  40                  45              


Arg Ile Asn Glu Ser Leu Ser Gln Leu Lys Thr Leu Ile Leu Asp Ala 
    50                  55                  60                  


Leu Lys Lys Asp Ser Ser Arg His Ser Lys Leu Glu Lys Ala Asp Ile 
65                  70                  75                  80  


Leu Glu Met Thr Val Lys His Leu Arg Asn Leu Gln Arg Ala Gln Met 
                85                  90                  95      


Thr Ala Ala Leu Ser Thr Asp Pro Ser Val Leu Gly Lys Tyr Arg Ala 
            100                 105                 110         


Gly Phe Ser Glu Cys Met Asn Glu Val Thr Arg Phe Leu Ser Thr Cys 
        115                 120                 125             


Glu Gly Val Asn Thr Glu Val Arg Thr Arg Leu Leu Gly His Leu Ala 
    130                 135                 140                 


Asn Cys Met Thr Gln Ile Asn Ala Met Thr Tyr Pro Gly Gln Pro His 
145                 150                 155                 160 


Pro Ala Leu Gln Ala Pro Pro Pro Pro Pro Pro Gly Pro Gly Gly Pro 
                165                 170                 175     


Gln His Ala Pro Phe Ala Pro Pro Pro Pro Leu Val Pro Ile Pro Gly 
            180                 185                 190         


Gly Ala Ala Pro Pro Pro Gly Gly Ala Pro Cys Lys Leu Gly Ser Gln 
        195                 200                 205             


Ala Gly Glu Ala Ala Lys Val Phe Gly Gly Phe Gln Val Val Pro Ala 
    210                 215                 220                 


Pro Asp Gly Gln Phe Ala Phe Leu Ile Pro Asn Gly Ala Phe Ala His 
225                 230                 235                 240 


Ser Gly Pro Val Ile Pro Val Tyr Thr Ser Asn Ser Gly Thr Ser Val 
                245                 250                 255     


Gly Pro Asn Ala Val Ser Pro Ser Ser Gly Pro Ser Leu Thr Ala Asp 
            260                 265                 270         


Ser Met Trp Arg Pro Trp Arg Asn 
        275                 280 


<210>  4947
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HES2__Homo_sapiens__XP_011539915

<400>  4947

Met Gly Leu Pro Arg Arg Ala Gly Asp Ala Ala Glu Leu Arg Lys Ser 
1               5                   10                  15      


Leu Lys Pro Leu Leu Glu Lys Arg Arg Arg Ala Arg Ile Asn Gln Ser 
            20                  25                  30          


Leu Ser Gln Leu Lys Gly Leu Ile Leu Pro Leu Leu Gly Arg Glu Asn 
        35                  40                  45              


Ser Asn Cys Ser Lys Leu Glu Lys Ala Asp Val Leu Glu Met Thr Val 
    50                  55                  60                  


Arg Phe Leu Gln Glu Leu Pro Ala Ser Ser Trp Pro Thr Ala Ala Pro 
65                  70                  75                  80  


Leu Pro Cys Asp Ser Tyr Arg Glu Gly Tyr Ser Ala Cys Val Ala Arg 
                85                  90                  95      


Leu Ala Arg Val Leu Pro Ala Cys Arg Val Leu Glu Pro Ala Val Ser 
            100                 105                 110         


Ala Arg Leu Leu Glu His Leu Trp Arg Arg Ala Ala Ser Ala Thr Leu 
        115                 120                 125             


Asp Gly Gly Arg Ala Gly Asp Ser Ser Gly Pro Ser Ala Pro Ala Pro 
    130                 135                 140                 


Ala Pro Ala Ser Ala Pro Glu Pro Ala Ser Ala Pro Val Pro Ser Pro 
145                 150                 155                 160 


Pro Ser Pro Pro Cys Gly Pro Gly Leu Trp Arg Pro Trp 
                165                 170             


<210>  4948
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HES6__Homo_sapiens__NP_001136325

<400>  4948

Met Ala Pro Pro Ala Ala Pro Gly Arg Asp Arg Val Gly Arg Glu Asp 
1               5                   10                  15      


Glu Asp Gly Trp Glu Thr Arg Gly Asp Arg Lys Ala Arg Lys Pro Leu 
            20                  25                  30          


Val Glu Lys Lys Arg Arg Ala Arg Ile Asn Glu Ser Leu Gln Glu Leu 
        35                  40                  45              


Arg Leu Leu Leu Ala Gly Ala Glu Ala Lys Leu Glu Asn Ala Glu Val 
    50                  55                  60                  


Leu Glu Leu Thr Val Arg Arg Val Gln Gly Val Leu Arg Gly Arg Ala 
65                  70                  75                  80  


Arg Glu Arg Glu Gln Leu Gln Ala Glu Ala Ser Glu Arg Phe Ala Ala 
                85                  90                  95      


Gly Tyr Ile Gln Cys Met His Glu Val His Thr Phe Val Ser Thr Cys 
            100                 105                 110         


Gln Ala Ile Asp Ala Thr Val Ala Ala Glu Leu Leu Asn His Leu Leu 
        115                 120                 125             


Glu Ser Met Pro Leu Arg Glu Gly Ser Ser Phe Gln Asp Leu Leu Gly 
    130                 135                 140                 


Asp Ala Leu Ala Gly Pro Pro Arg Ala Pro Gly Arg Ser Gly Trp Pro 
145                 150                 155                 160 


Ala Gly Gly Ala Pro Gly Ser Pro Ile Pro Ser Pro Pro Gly Pro Gly 
                165                 170                 175     


Asp Asp Leu Cys Ser Asp Leu Glu Glu Ala Pro Glu Ala Glu Leu Ser 
            180                 185                 190         


Gln Ala Pro Ala Glu Gly Pro Asp Leu Val Pro Ala Ala Leu Gly Ser 
        195                 200                 205             


Leu Thr Thr Ala Gln Ile Ala Arg Ser Val Trp Arg Pro Trp 
    210                 215                 220         


<210>  4949
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HES7__Homo_sapiens__NP_001159439

<400>  4949

Met Val Thr Arg Asp Arg Ala Glu Asn Arg Asp Gly Pro Lys Met Leu 
1               5                   10                  15      


Lys Pro Leu Val Glu Lys Arg Arg Arg Asp Arg Ile Asn Arg Ser Leu 
            20                  25                  30          


Glu Glu Leu Arg Leu Leu Leu Leu Glu Arg Thr Arg Asp Gln Asn Leu 
        35                  40                  45              


Arg Asn Pro Lys Leu Glu Lys Ala Glu Ile Leu Glu Phe Ala Val Gly 
    50                  55                  60                  


Tyr Leu Arg Glu Arg Ser Arg Val Glu Pro Pro Ala Ala Ala Ala Pro 
65                  70                  75                  80  


Gly Val Pro Arg Ser Pro Val Gln Asp Ala Glu Ala Leu Ala Ser Cys 
                85                  90                  95      


Tyr Leu Ser Gly Phe Arg Glu Cys Leu Leu Arg Leu Ala Ala Phe Ala 
            100                 105                 110         


His Asp Ala Ser Pro Ala Ala Arg Ala Gln Leu Phe Ser Ala Leu His 
        115                 120                 125             


Gly Tyr Leu Arg Pro Lys Pro Pro Arg Pro Lys Pro Val Asp Pro Arg 
    130                 135                 140                 


Pro Pro Ala Pro Arg Pro Ser Leu Asp Pro Ala Ala Pro Ala Leu Gly 
145                 150                 155                 160 


Pro Ala Leu His Gln Arg Pro Pro Val His Gln Gly His Pro Ser Pro 
                165                 170                 175     


Arg Cys Ala Trp Ser Pro Ser Leu Cys Ser Pro Arg Ala Gly Asp Ser 
            180                 185                 190         


Gly Ala Pro Ala Pro Leu Thr Gly Leu Leu Pro Pro Pro Pro Pro Pro 
        195                 200                 205             


His Arg Gln Asp Gly Ala Pro Lys Ala Pro Leu Pro Pro Pro Pro Ala 
    210                 215                 220                 


Phe Trp Arg Pro Trp Pro 
225                 230 


<210>  4950
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HESX1__Homo_sapiens__NP_003856

<400>  4950

Met Ser Pro Ser Leu Gln Glu Gly Ala Gln Leu Gly Glu Asn Lys Pro 
1               5                   10                  15      


Ser Thr Cys Ser Phe Ser Ile Glu Arg Ile Leu Gly Leu Asp Gln Lys 
            20                  25                  30          


Lys Asp Cys Val Pro Leu Met Lys Pro His Arg Pro Trp Ala Asp Thr 
        35                  40                  45              


Cys Ser Ser Ser Gly Lys Asp Gly Asn Leu Cys Leu His Val Pro Asn 
    50                  55                  60                  


Pro Pro Ser Gly Ile Ser Phe Pro Ser Val Val Asp His Pro Met Pro 
65                  70                  75                  80  


Glu Glu Arg Ala Ser Lys Tyr Glu Asn Tyr Phe Ser Ala Ser Glu Arg 
                85                  90                  95      


Leu Ser Leu Lys Arg Glu Leu Ser Trp Tyr Arg Gly Arg Arg Pro Arg 
            100                 105                 110         


Thr Ala Phe Thr Gln Asn Gln Ile Glu Val Leu Glu Asn Val Phe Arg 
        115                 120                 125             


Val Asn Cys Tyr Pro Gly Ile Asp Ile Arg Glu Asp Leu Ala Gln Lys 
    130                 135                 140                 


Leu Asn Leu Glu Glu Asp Arg Ile Gln Ile Trp Phe Gln Asn Arg Arg 
145                 150                 155                 160 


Ala Lys Leu Lys Arg Ser His Arg Glu Ser Gln Phe Leu Met Ala Lys 
                165                 170                 175     


Lys Asn Phe Asn Thr Asn Leu Leu Glu 
            180                 185 


<210>  4951
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEXA__Homo_sapiens__NP_000511

<400>  4951

Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val 
            180                 185                 190         


Met Ala Tyr Asn Lys Leu Asn Val Phe His Trp His Leu Val Asp Asp 
        195                 200                 205             


Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys 
    210                 215                 220                 


Gly Ser Tyr Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys 
225                 230                 235                 240 


Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu 
                245                 250                 255     


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly 
            260                 265                 270         


Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly 
        275                 280                 285             


Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe 
    290                 295                 300                 


Phe Leu Glu Val Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly 
305                 310                 315                 320 


Gly Asp Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln 
                325                 330                 335     


Asp Phe Met Arg Lys Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu 
            340                 345                 350         


Ser Phe Tyr Ile Gln Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys 
        355                 360                 365             


Gly Tyr Val Val Trp Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln 
    370                 375                 380                 


Pro Asp Thr Ile Ile Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr 
385                 390                 395                 400 


Met Lys Glu Leu Glu Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu 
                405                 410                 415     


Ser Ala Pro Trp Tyr Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys 
            420                 425                 430         


Asp Phe Tyr Ile Val Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln 
        435                 440                 445             


Lys Ala Leu Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val 
    450                 455                 460                 


Asp Asn Thr Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val 
465                 470                 475                 480 


Ala Glu Arg Leu Trp Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala 
                485                 490                 495     


Tyr Glu Arg Leu Ser His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val 
            500                 505                 510         


Gln Ala Gln Pro Leu Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln 
        515                 520                 525             


Thr 
    


<210>  4952
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEXB__Homo_sapiens__NP_000512

<400>  4952

Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln 
            20                  25                  30          


Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val 
        35                  40                  45              


Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Ser Val Lys 
    50                  55                  60                  


Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser 
65                  70                  75                  80  


His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu 
                85                  90                  95      


Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His 
            100                 105                 110         


His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu 
        115                 120                 125             


Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser 
    130                 135                 140                 


Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu 
145                 150                 155                 160 


Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser 
                165                 170                 175     


Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser 
            180                 185                 190         


Thr Ile Ile Asp Ser Pro Arg Phe Ser His Arg Gly Ile Leu Ile Asp 
        195                 200                 205             


Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp 
    210                 215                 220                 


Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp 
225                 230                 235                 240 


Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn 
                245                 250                 255     


Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg 
            260                 265                 270         


Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu 
        275                 280                 285             


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp 
    290                 295                 300                 


Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly 
305                 310                 315                 320 


Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe 
                325                 330                 335     


Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly 
            340                 345                 350         


Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro Lys Ile Gln 
        355                 360                 365             


Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu 
    370                 375                 380                 


Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys 
385                 390                 395                 400 


Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala 
                405                 410                 415     


Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu 
            420                 425                 430         


Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro 
        435                 440                 445             


Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr 
    450                 455                 460                 


Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu 
465                 470                 475                 480 


Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr 
                485                 490                 495     


Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg 
            500                 505                 510         


Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg 
        515                 520                 525             


Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln 
    530                 535                 540                 


Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met 
545                 550                 555     


<210>  4953
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEXDC__Homo_sapiens__NP_775891

<400>  4953

Met Ser Gly Ser Thr Pro Phe Gln Met Arg Leu Val His Leu Asp Leu 
1               5                   10                  15      


Lys Gly Ala Pro Pro Lys Val Ser Tyr Leu Ser Glu Ile Phe Pro Leu 
            20                  25                  30          


Phe Arg Ala Leu Gly Ala Asn Gly Leu Leu Ile Glu Tyr Glu Asp Met 
        35                  40                  45              


Phe Pro Tyr Glu Gly Pro Leu Arg Leu Leu Arg Ala Lys Tyr Ala Tyr 
    50                  55                  60                  


Ser Pro Ser Glu Ile Lys Glu Ile Leu His Leu Ala Gly Leu Asn Glu 
65                  70                  75                  80  


Leu Glu Val Ile Pro Leu Val Gln Thr Phe Gly His Met Glu Phe Val 
                85                  90                  95      


Leu Lys His Thr Ala Phe Ala His Leu Arg Glu Val Gly Ser Phe Pro 
            100                 105                 110         


Cys Thr Leu Asn Pro His Glu Ala Glu Ser Leu Ala Leu Val Gly Ala 
        115                 120                 125             


Met Ile Asp Gln Val Leu Glu Leu His Pro Gly Ala Gln Arg Leu His 
    130                 135                 140                 


Ile Gly Cys Asp Glu Val Tyr Tyr Leu Gly Glu Gly Glu Ala Ser Arg 
145                 150                 155                 160 


Arg Trp Leu Gln Gln Glu Gln Asn Ser Thr Gly Lys Leu Cys Leu Ser 
                165                 170                 175     


His Met Arg Ala Val Ala Ser Gly Val Lys Ala Arg Arg Pro Ser Val 
            180                 185                 190         


Thr Pro Leu Val Trp Asp Asp Met Leu Arg Asp Leu Pro Glu Asp Gln 
        195                 200                 205             


Leu Ala Ala Ser Gly Val Pro Gln Leu Val Glu Pro Val Leu Trp Asp 
    210                 215                 220                 


Tyr Thr Ala Asp Leu Asp Val His Gly Lys Val Leu Leu Met Gln Lys 
225                 230                 235                 240 


Tyr Arg Arg Cys Gly Phe Pro Gln Leu Trp Ala Ala Ser Ala Phe Lys 
                245                 250                 255     


Gly Ala Thr Gly Pro Ser Gln Ala Val Pro Pro Val Glu His His Leu 
            260                 265                 270         


Arg Asn His Val Gln Trp Leu Gln Val Ala Gly Ser Gly Pro Thr Asp 
        275                 280                 285             


Ser Leu Gln Gly Ile Ile Leu Thr Gly Trp Gln Arg Tyr Asp His Tyr 
    290                 295                 300                 


Ser Val Leu Cys Glu Leu Leu Pro Ala Gly Val Pro Ser Leu Ala Ala 
305                 310                 315                 320 


Cys Leu Gln Leu Leu Leu Arg Gly Gly Phe Asp Glu Asp Val Lys Ala 
                325                 330                 335     


Lys Val Glu Asn Leu Leu Gly Ile Ser Ser Leu Glu Lys Thr Asp Pro 
            340                 345                 350         


Val Arg Gln Ala Pro Cys Ser Pro Pro Cys Pro Leu Leu Pro Leu Pro 
        355                 360                 365             


Phe Pro Arg Pro Trp Arg Gln Leu Phe Ser Ala Gly Leu Ser Ala Gly 
    370                 375                 380                 


Arg Gly Pro Ala Pro Ser Leu Ala Ala Thr Ser Leu Pro Leu Ser His 
385                 390                 395                 400 


Lys Ser Ala Ser Ile Cys Ala Ala Leu Trp Met Arg Cys Trp Arg Ala 
                405                 410                 415     


Thr Gly Met Ser Leu Ala Gly Ser Ala Pro Thr Thr Ala Ser Gly Ser 
            420                 425                 430         


Ser Ser Thr Arg Ser Trp Phe Ser Thr Ser Ser Pro Gln Arg Ser Ala 
        435                 440                 445             


Ser Trp His Ser Gly Ala Pro Ser Cys Arg Ser Trp Arg Leu Pro Cys 
    450                 455                 460                 


Ser Trp Leu Ser Thr Arg Met Pro Trp Arg Ser Gly Trp Arg Lys Thr 
465                 470                 475                 480 


Cys Thr Pro Ala Cys Ser Gly Cys Lys Leu Cys Cys Arg Thr Ser Ala 
                485                 490                 495     


Arg Cys Leu Pro Pro Arg Cys His Pro Pro Ala Leu Ala Gly Thr Leu 
            500                 505                 510         


Leu Arg Thr Pro Glu Gly Arg Ala His Ala Arg Gly Leu Leu Leu Glu 
        515                 520                 525             


Ala Gly Gly Ala Leu His Cys Gln Met Ala Trp Ala Ile Arg Ala His 
    530                 535                 540                 


Val Gly Val Val Pro Ser Gly Pro Ala Val Ser Cys Pro His Ser Val 
545                 550                 555                 560 


Pro Glu Gly Pro Gly Gln Pro Leu Gly Glu Arg Leu Glu Asn Thr Glu 
                565                 570                 575     


Gly Ser Ser Thr Gly Arg Pro Ala Leu 
            580                 585 


<210>  4954
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEXIM1__Homo_sapiens__NP_006451

<400>  4954

Met Ala Glu Pro Phe Leu Ser Glu Tyr Gln His Gln Pro Gln Thr Ser 
1               5                   10                  15      


Asn Cys Thr Gly Ala Ala Ala Val Gln Glu Glu Leu Asn Pro Glu Arg 
            20                  25                  30          


Pro Pro Gly Ala Glu Glu Arg Val Pro Glu Glu Asp Ser Arg Trp Gln 
        35                  40                  45              


Ser Arg Ala Phe Pro Gln Leu Gly Gly Arg Pro Gly Pro Glu Gly Glu 
    50                  55                  60                  


Gly Ser Leu Glu Ser Gln Pro Pro Pro Leu Gln Thr Gln Ala Cys Pro 
65                  70                  75                  80  


Glu Ser Ser Cys Leu Arg Glu Gly Glu Lys Gly Gln Asn Gly Asp Asp 
                85                  90                  95      


Ser Ser Ala Gly Gly Asp Phe Pro Pro Pro Ala Glu Val Glu Pro Thr 
            100                 105                 110         


Pro Glu Ala Glu Leu Leu Ala Gln Pro Cys His Asp Ser Glu Ala Ser 
        115                 120                 125             


Lys Leu Gly Ala Pro Ala Ala Gly Gly Glu Glu Glu Trp Gly Gln Gln 
    130                 135                 140                 


Gln Arg Gln Leu Gly Lys Lys Lys His Arg Arg Arg Pro Ser Lys Lys 
145                 150                 155                 160 


Lys Arg His Trp Lys Pro Tyr Tyr Lys Leu Thr Trp Glu Glu Lys Lys 
                165                 170                 175     


Lys Phe Asp Glu Lys Gln Ser Leu Arg Ala Ser Arg Ile Arg Ala Glu 
            180                 185                 190         


Met Phe Ala Lys Gly Gln Pro Val Ala Pro Tyr Asn Thr Thr Gln Phe 
        195                 200                 205             


Leu Met Asp Asp His Asp Gln Glu Glu Pro Asp Leu Lys Thr Gly Leu 
    210                 215                 220                 


Tyr Ser Lys Arg Ala Ala Ala Lys Ser Asp Asp Thr Ser Asp Asp Asp 
225                 230                 235                 240 


Phe Met Glu Glu Gly Gly Glu Glu Asp Gly Gly Ser Asp Gly Met Gly 
                245                 250                 255     


Gly Asp Gly Ser Glu Phe Leu Gln Arg Asp Phe Ser Glu Thr Tyr Glu 
            260                 265                 270         


Arg Tyr His Thr Glu Ser Leu Gln Asn Met Ser Lys Gln Glu Leu Ile 
        275                 280                 285             


Lys Glu Tyr Leu Glu Leu Glu Lys Cys Leu Ser Arg Met Glu Asp Glu 
    290                 295                 300                 


Asn Asn Arg Leu Arg Leu Glu Ser Lys Arg Leu Gly Gly Asp Asp Ala 
305                 310                 315                 320 


Arg Val Arg Glu Leu Glu Leu Glu Leu Asp Arg Leu Arg Ala Glu Asn 
                325                 330                 335     


Leu Gln Leu Leu Thr Glu Asn Glu Leu His Arg Gln Gln Glu Arg Ala 
            340                 345                 350         


Pro Leu Ser Lys Phe Gly Asp 
        355                 


<210>  4955
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEY1__Homo_sapiens__NP_001035798

<400>  4955

Met Lys Arg Ala His Pro Glu Tyr Ser Ser Ser Asp Ser Glu Leu Asp 
1               5                   10                  15      


Glu Thr Ile Glu Val Glu Lys Glu Ser Ala Asp Glu Asn Gly Asn Leu 
            20                  25                  30          


Ser Ser Ala Leu Gly Ser Met Ser Pro Thr Thr Ser Ser Gln Ile Leu 
        35                  40                  45              


Ala Arg Lys Arg Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg 
    50                  55                  60                  


Ile Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Ser Ala Phe 
65                  70                  75                  80  


Glu Lys Gln Val Met Glu Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu 
                85                  90                  95      


Ile Leu Gln Met Thr Val Asp His Leu Lys Met Leu His Thr Ala Gly 
            100                 105                 110         


Gly Lys Gly Tyr Phe Asp Ala His Ala Leu Ala Met Asp Tyr Arg Ser 
        115                 120                 125             


Leu Gly Phe Arg Glu Cys Leu Ala Glu Val Ala Arg Tyr Leu Ser Ile 
    130                 135                 140                 


Ile Glu Gly Leu Asp Ala Ser Asp Pro Leu Arg Val Arg Leu Val Ser 
145                 150                 155                 160 


His Leu Asn Asn Tyr Ala Ser Gln Arg Glu Ala Ala Ser Gly Ala His 
                165                 170                 175     


Ala Gly Leu Gly His Ile Pro Trp Gly Thr Val Phe Gly His His Pro 
            180                 185                 190         


His Ile Ala His Pro Leu Leu Leu Pro Gln Asn Gly His Gly Asn Ala 
        195                 200                 205             


Gly Thr Thr Ala Ser Pro Thr Glu Pro His His Gln Gly Arg Leu Gly 
    210                 215                 220                 


Ser Ala His Pro Glu Ala Pro Ala Leu Arg Ala Pro Pro Ser Gly Ser 
225                 230                 235                 240 


Leu Gly Pro Val Leu Pro Val Val Thr Ser Ala Ser Lys Leu Ser Pro 
                245                 250                 255     


Pro Leu Leu Ser Ser Val Ala Ser Leu Ser Ala Phe Pro Phe Ser Phe 
            260                 265                 270         


Gly Ser Phe His Leu Leu Ser Pro Asn Ala Leu Ser Pro Ser Ala Pro 
        275                 280                 285             


Thr Gln Ala Ala Asn Leu Gly Lys Pro Tyr Arg Pro Trp Gly Thr Glu 
    290                 295                 300                 


Ile Gly Ala Phe 
305             


<210>  4956
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEY2__Homo_sapiens__NP_036391

<400>  4956

Met Lys Arg Pro Cys Glu Glu Thr Thr Ser Glu Ser Asp Met Asp Glu 
1               5                   10                  15      


Thr Ile Asp Val Gly Ser Glu Asn Asn Tyr Ser Gly Gln Ser Thr Ser 
            20                  25                  30          


Ser Val Ile Arg Leu Asn Ser Pro Thr Thr Thr Ser Gln Ile Met Ala 
        35                  40                  45              


Arg Lys Lys Arg Arg Gly Ile Ile Glu Lys Arg Arg Arg Asp Arg Ile 
    50                  55                  60                  


Asn Asn Ser Leu Ser Glu Leu Arg Arg Leu Val Pro Thr Ala Phe Glu 
65                  70                  75                  80  


Lys Gln Gly Ser Ala Lys Leu Glu Lys Ala Glu Ile Leu Gln Met Thr 
                85                  90                  95      


Val Asp His Leu Lys Met Leu Gln Ala Thr Gly Gly Lys Gly Tyr Phe 
            100                 105                 110         


Asp Ala His Ala Leu Ala Met Asp Phe Met Ser Ile Gly Phe Arg Glu 
        115                 120                 125             


Cys Leu Thr Glu Val Ala Arg Tyr Leu Ser Ser Val Glu Gly Leu Asp 
    130                 135                 140                 


Ser Ser Asp Pro Leu Arg Val Arg Leu Val Ser His Leu Ser Thr Cys 
145                 150                 155                 160 


Ala Thr Gln Arg Glu Ala Ala Ala Met Thr Ser Ser Met Ala His His 
                165                 170                 175     


His His Pro Leu His Pro His His Trp Ala Ala Ala Phe His His Leu 
            180                 185                 190         


Pro Ala Ala Leu Leu Gln Pro Asn Gly Leu His Ala Ser Glu Ser Thr 
        195                 200                 205             


Pro Cys Arg Leu Ser Thr Thr Ser Glu Val Pro Pro Ala His Gly Ser 
    210                 215                 220                 


Ala Leu Leu Thr Ala Thr Phe Ala His Ala Asp Ser Ala Leu Arg Met 
225                 230                 235                 240 


Pro Ser Thr Gly Ser Val Ala Pro Cys Val Pro Pro Leu Ser Thr Ser 
                245                 250                 255     


Leu Leu Ser Leu Ser Ala Thr Val His Ala Ala Ala Ala Ala Ala Thr 
            260                 265                 270         


Ala Ala Ala His Ser Phe Pro Leu Ser Phe Ala Gly Ala Phe Pro Met 
        275                 280                 285             


Leu Pro Pro Asn Ala Ala Ala Ala Val Ala Ala Ala Thr Ala Ile Ser 
    290                 295                 300                 


Pro Pro Leu Ser Val Ser Ala Thr Ser Ser Pro Gln Gln Thr Ser Ser 
305                 310                 315                 320 


Gly Thr Asn Asn Lys Pro Tyr Arg Pro Trp Gly Thr Glu Val Gly Ala 
                325                 330                 335     


Phe 
    


<210>  4957
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFE__Homo_sapiens__NP_000401

<400>  4957

Met Gly Pro Arg Ala Arg Pro Ala Leu Leu Leu Leu Met Leu Leu Gln 
1               5                   10                  15      


Thr Ala Val Leu Gln Gly Arg Leu Leu Arg Ser His Ser Leu His Tyr 
            20                  25                  30          


Leu Phe Met Gly Ala Ser Glu Gln Asp Leu Gly Leu Ser Leu Phe Glu 
        35                  40                  45              


Ala Leu Gly Tyr Val Asp Asp Gln Leu Phe Val Phe Tyr Asp His Glu 
    50                  55                  60                  


Ser Arg Arg Val Glu Pro Arg Thr Pro Trp Val Ser Ser Arg Ile Ser 
65                  70                  75                  80  


Ser Gln Met Trp Leu Gln Leu Ser Gln Ser Leu Lys Gly Trp Asp His 
                85                  90                  95      


Met Phe Thr Val Asp Phe Trp Thr Ile Met Glu Asn His Asn His Ser 
            100                 105                 110         


Lys Glu Ser His Thr Leu Gln Val Ile Leu Gly Cys Glu Met Gln Glu 
        115                 120                 125             


Asp Asn Ser Thr Glu Gly Tyr Trp Lys Tyr Gly Tyr Asp Gly Gln Asp 
    130                 135                 140                 


His Leu Glu Phe Cys Pro Asp Thr Leu Asp Trp Arg Ala Ala Glu Pro 
145                 150                 155                 160 


Arg Ala Trp Pro Thr Lys Leu Glu Trp Glu Arg His Lys Ile Arg Ala 
                165                 170                 175     


Arg Gln Asn Arg Ala Tyr Leu Glu Arg Asp Cys Pro Ala Gln Leu Gln 
            180                 185                 190         


Gln Leu Leu Glu Leu Gly Arg Gly Val Leu Asp Gln Gln Val Pro Pro 
        195                 200                 205             


Leu Val Lys Val Thr His His Val Thr Ser Ser Val Thr Thr Leu Arg 
    210                 215                 220                 


Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys Trp Leu 
225                 230                 235                 240 


Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys Asp Val 
                245                 250                 255     


Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu Ala Val 
            260                 265                 270         


Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val Glu His Pro Gly 
        275                 280                 285             


Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser Pro Ser Gly Thr 
    290                 295                 300                 


Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val Ile Leu 
305                 310                 315                 320 


Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly Ser Arg 
                325                 330                 335     


Gly Ala Met Gly His Tyr Val Leu Ala Glu Arg Glu 
            340                 345             


<210>  4958
<211>  1435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFM1__Homo_sapiens__XP_011539154

<400>  4958

Met Leu Lys Ser Asn Asp Cys Leu Phe Ser Leu Glu Asn Leu Phe Phe 
1               5                   10                  15      


Glu Lys Pro Asp Glu Val Glu Asn His Pro Asp Asn Glu Lys Ser Leu 
            20                  25                  30          


Asp Trp Phe Leu Pro Pro Ala Pro Leu Ile Ser Glu Ile Pro Asp Thr 
        35                  40                  45              


Gln Glu Leu Glu Glu Glu Leu Glu Ser His Lys Leu Leu Gly Gln Glu 
    50                  55                  60                  


Lys Arg Pro Lys Met Leu Thr Ser Asn Leu Lys Ile Thr Asn Glu Asp 
65                  70                  75                  80  


Thr Asn Tyr Ile Ser Leu Thr Gln Lys Phe Gln Phe Ala Phe Pro Ser 
                85                  90                  95      


Asp Lys Tyr Glu Gln Asp Asp Leu Asn Leu Glu Gly Val Gly Asn Asn 
            100                 105                 110         


Asp Leu Ser His Ile Ala Gly Lys Leu Thr Tyr Ala Ser Gln Lys Tyr 
        115                 120                 125             


Lys Asn His Ile Gly Thr Glu Ile Ala Pro Glu Lys Ser Val Pro Asp 
    130                 135                 140                 


Asp Thr Lys Leu Val Asn Phe Ala Glu Asp Lys Gly Glu Ser Thr Ser 
145                 150                 155                 160 


Val Phe Arg Lys Arg Leu Phe Lys Ile Ser Asp Asn Ile His Gly Ser 
                165                 170                 175     


Ala Tyr Ser Asn Asp Asn Glu Leu Asp Ser His Ile Gly Ser Val Lys 
            180                 185                 190         


Ile Val Gln Thr Glu Met Asn Lys Gly Lys Ser Arg Asn Tyr Ser Asn 
        195                 200                 205             


Ser Lys Gln Lys Phe Gln Tyr Ser Ala Asn Val Phe Thr Ala Asn Asn 
    210                 215                 220                 


Ala Phe Ser Ala Ser Glu Ile Gly Glu Gly Met Phe Lys Ala Pro Ser 
225                 230                 235                 240 


Phe Ser Val Ala Phe Gln Pro His Asp Ile Gln Glu Val Thr Glu Asn 
                245                 250                 255     


Gly Leu Gly Ser Leu Lys Ala Val Thr Glu Ile Pro Ala Lys Phe Arg 
            260                 265                 270         


Ser Ile Phe Lys Glu Phe Pro Tyr Phe Asn Tyr Ile Gln Ser Lys Ala 
        275                 280                 285             


Phe Asp Asp Leu Leu Tyr Thr Asp Arg Asn Phe Val Ile Cys Ala Pro 
    290                 295                 300                 


Thr Gly Ser Gly Lys Thr Val Val Phe Glu Leu Ala Ile Thr Arg Leu 
305                 310                 315                 320 


Leu Met Glu Val Pro Leu Pro Trp Leu Asn Ile Lys Ile Val Tyr Met 
                325                 330                 335     


Ala Pro Ile Lys Ala Leu Cys Ser Gln Arg Phe Asp Asp Trp Lys Glu 
            340                 345                 350         


Lys Phe Gly Pro Ile Gly Leu Asn Cys Lys Glu Leu Thr Gly Asp Thr 
        355                 360                 365             


Val Met Asp Asp Leu Phe Glu Ile Gln His Ala His Ile Ile Met Thr 
    370                 375                 380                 


Thr Pro Glu Lys Trp Asp Ser Met Thr Arg Lys Trp Arg Asp Asn Ser 
385                 390                 395                 400 


Leu Val Gln Leu Val Arg Leu Phe Leu Ile Asp Glu Val His Ile Val 
                405                 410                 415     


Lys Asp Glu Asn Arg Gly Pro Thr Leu Glu Val Val Val Ser Arg Met 
            420                 425                 430         


Lys Thr Val Gln Ser Val Ser Gln Thr Leu Lys Asn Thr Ser Thr Ala 
        435                 440                 445             


Ile Pro Met Arg Phe Val Ala Val Ser Ala Thr Ile Pro Asn Ala Glu 
    450                 455                 460                 


Asp Ile Ala Glu Trp Leu Ser Asp Gly Glu Arg Pro Ala Val Cys Leu 
465                 470                 475                 480 


Lys Met Asp Glu Ser His Arg Pro Val Lys Leu Gln Lys Val Val Leu 
                485                 490                 495     


Gly Phe Pro Cys Ser Ser Asn Gln Thr Glu Phe Lys Phe Asp Leu Thr 
            500                 505                 510         


Leu Asn Tyr Lys Ile Ala Ser Val Ile Gln Met Tyr Ser Asp Gln Lys 
        515                 520                 525             


Pro Thr Leu Val Phe Cys Ala Thr Arg Lys Gly Val Gln Gln Ala Ala 
    530                 535                 540                 


Ser Val Leu Val Lys Asp Ala Lys Phe Ile Met Thr Val Glu Gln Lys 
545                 550                 555                 560 


Gln Arg Leu Gln Lys Tyr Ala Tyr Ser Val Arg Asp Ser Lys Leu Arg 
                565                 570                 575     


Asp Ile Leu Lys Asp Gly Ala Ala Tyr His His Ala Gly Met Glu Leu 
            580                 585                 590         


Ser Asp Arg Lys Val Val Glu Gly Ala Phe Thr Val Gly Asp Leu Pro 
        595                 600                 605             


Val Leu Phe Thr Thr Ser Thr Leu Ala Met Gly Val Asn Leu Pro Ala 
    610                 615                 620                 


His Leu Val Val Ile Lys Ser Thr Met His Tyr Ala Gly Gly Leu Phe 
625                 630                 635                 640 


Glu Glu Tyr Ser Glu Thr Asp Ile Leu Gln Met Ile Gly Arg Ala Gly 
                645                 650                 655     


Arg Pro Gln Phe Asp Thr Thr Ala Thr Ala Val Ile Met Thr Arg Leu 
            660                 665                 670         


Ser Thr Arg Asp Lys Tyr Ile Gln Met Leu Ala Cys Arg Asp Thr Val 
        675                 680                 685             


Glu Ser Ser Leu His Arg His Leu Ile Glu His Leu Asn Ala Glu Ile 
    690                 695                 700                 


Val Leu His Thr Ile Thr Asp Val Asn Ile Ala Val Glu Trp Ile Arg 
705                 710                 715                 720 


Ser Thr Leu Leu Tyr Ile Arg Ala Leu Lys Asn Pro Ser His Tyr Gly 
                725                 730                 735     


Phe Ala Ser Gly Leu Asn Lys Asp Gly Ile Glu Ala Lys Leu Gln Glu 
            740                 745                 750         


Leu Cys Leu Lys Asn Leu Asn Asp Leu Ser Ser Leu Asp Leu Ile Lys 
        755                 760                 765             


Met Asp Glu Gly Val Asn Phe Lys Pro Thr Glu Ala Gly Arg Leu Met 
    770                 775                 780                 


Ala Trp Tyr Tyr Ile Thr Phe Glu Thr Val Lys Lys Phe Tyr Thr Ile 
785                 790                 795                 800 


Ser Gly Lys Glu Thr Leu Ser Asp Leu Val Thr Leu Ile Ala Gly Cys 
                805                 810                 815     


Lys Glu Phe Leu Asp Ile Gln Leu Arg Ile Asn Glu Lys Lys Thr Leu 
            820                 825                 830         


Asn Thr Leu Asn Lys Asp Pro Asn Arg Ile Thr Ile Arg Phe Pro Met 
        835                 840                 845             


Glu Gly Arg Ile Lys Thr Arg Glu Met Lys Val Asn Cys Leu Ile Gln 
    850                 855                 860                 


Ala Gln Leu Gly Cys Ile Pro Ile Gln Asp Phe Ala Leu Thr Gln Asp 
865                 870                 875                 880 


Thr Ala Lys Ile Phe Arg His Gly Ser Arg Ile Thr Arg Trp Leu Ser 
                885                 890                 895     


Asp Phe Val Ala Ala Gln Glu Lys Lys Phe Ala Val Leu Leu Asn Ser 
            900                 905                 910         


Leu Ile Leu Ala Lys Cys Phe Arg Cys Lys Leu Trp Glu Asn Ser Leu 
        915                 920                 925             


His Val Ser Lys Gln Leu Glu Lys Ile Gly Ile Thr Leu Ser Asn Ala 
    930                 935                 940                 


Ile Val Asn Ala Gly Leu Thr Ser Phe Lys Lys Ile Glu Glu Thr Asp 
945                 950                 955                 960 


Ala Arg Glu Leu Glu Leu Ile Leu Asn Arg His Pro Pro Phe Gly Thr 
                965                 970                 975     


Gln Ile Lys Glu Thr Val Met Tyr Leu Pro Lys Tyr Glu Leu Lys Val 
            980                 985                 990         


Glu Gln Ile Thr Arg Tyr Ser Asp  Thr Thr Ala Glu Ile  Leu Val Thr 
        995                 1000                 1005             


Val Ile  Leu Arg Asn Phe Glu  Gln Leu Gln Thr Lys  Arg Thr Ala 
    1010                 1015                 1020             


Ser Asp  Ser His Tyr Val Thr  Leu Ile Ile Gly Asp  Ala Asp Asn 
    1025                 1030                 1035             


Gln Val  Val Tyr Leu His Lys  Ile Thr Asp Ser Val  Leu Leu Lys 
    1040                 1045                 1050             


Ala Gly  Ser Trp Ala Lys Lys  Ile Ala Val Lys Arg  Ala Leu Lys 
    1055                 1060                 1065             


Ser Glu  Asp Leu Ser Ile Asn  Leu Ile Ser Ser Glu  Phe Val Gly 
    1070                 1075                 1080             


Leu Asp  Ile Gln Gln Lys Leu  Thr Val Phe Tyr Leu  Glu Pro Lys 
    1085                 1090                 1095             


Arg Phe  Gly Asn Gln Ile Thr  Met Gln Arg Lys Ser  Glu Thr Gln 
    1100                 1105                 1110             


Ile Ser  His Ser Lys His Ser  Asp Ile Ser Thr Ile  Ala Gly Pro 
    1115                 1120                 1125             


Asn Lys  Gly Thr Thr Ala Ser  Lys Lys Pro Gly Asn  Arg Glu Cys 
    1130                 1135                 1140             


Asn His  Leu Cys Lys Ser Lys  His Thr Cys Gly His  Asp Cys Cys 
    1145                 1150                 1155             


Lys Ile  Gly Val Ala Gln Lys  Ser Glu Ile Lys Glu  Ser Thr Ile 
    1160                 1165                 1170             


Ser Ser  Tyr Leu Ser Asp Leu  Arg Asn Arg Asn Ala  Val Ser Ser 
    1175                 1180                 1185             


Val Pro  Pro Val Lys Arg Leu  Lys Ile Gln Met Asn  Lys Ser Gln 
    1190                 1195                 1200             


Ser Val  Asp Leu Lys Glu Phe  Gly Phe Thr Pro Lys  Pro Ser Leu 
    1205                 1210                 1215             


Pro Ser  Ile Ser Arg Ser Glu  Tyr Leu Asn Ile Ser  Glu Leu Pro 
    1220                 1225                 1230             


Ile Met  Glu Gln Trp Asp Gln  Pro Glu Ile Tyr Gly  Lys Val Arg 
    1235                 1240                 1245             


Gln Glu  Pro Ser Glu Tyr Gln  Asp Lys Glu Val Leu  Asn Val Asn 
    1250                 1255                 1260             


Phe Glu  Leu Gly Asn Glu Val  Trp Asp Asp Phe Asp  Asp Glu Asn 
    1265                 1270                 1275             


Leu Glu  Val Thr Ser Phe Ser  Thr Asp Thr Glu Lys  Thr Lys Ile 
    1280                 1285                 1290             


Ser Gly  Phe Gly Asn Thr Leu  Ser Ser Ser Thr Arg  Gly Ser Lys 
    1295                 1300                 1305             


Leu Pro  Leu Gln Glu Ser Lys  Ser Lys Phe Gln Arg  Glu Met Ser 
    1310                 1315                 1320             


Asn Ser  Phe Val Ser Ser His  Glu Met Ser Asp Ile  Ser Leu Ser 
    1325                 1330                 1335             


Asn Ser  Ala Met Pro Lys Phe  Ser Ala Ser Ser Met  Thr Lys Leu 
    1340                 1345                 1350             


Pro Gln  Gln Ala Gly Asn Ala  Val Ile Val His Phe  Gln Glu Arg 
    1355                 1360                 1365             


Lys Pro  Gln Asn Leu Ser Pro  Glu Ile Glu Lys Gln  Cys Phe Thr 
    1370                 1375                 1380             


Phe Ser  Glu Lys Asn Pro Asn  Ser Ser Asn Tyr Lys  Lys Val Asp 
    1385                 1390                 1395             


Phe Phe  Ile Arg Asn Ser Glu  Cys Lys Lys Glu Val  Asp Phe Ser 
    1400                 1405                 1410             


Met Tyr  His Pro Asp Asp Glu  Ala Asp Glu Met Lys  Ser Leu Leu 
    1415                 1420                 1425             


Gly Ile  Phe Asp Gly Ile Phe  
    1430                 1435 


<210>  4959
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGD__Homo_sapiens__NP_000178

<400>  4959

Met Ala Glu Leu Lys Tyr Ile Ser Gly Phe Gly Asn Glu Cys Ser Ser 
1               5                   10                  15      


Glu Asp Pro Arg Cys Pro Gly Ser Leu Pro Glu Gly Gln Asn Asn Pro 
            20                  25                  30          


Gln Val Cys Pro Tyr Asn Leu Tyr Ala Glu Gln Leu Ser Gly Ser Ala 
        35                  40                  45              


Phe Thr Cys Pro Arg Ser Thr Asn Lys Arg Ser Trp Leu Tyr Arg Ile 
    50                  55                  60                  


Leu Pro Ser Val Ser His Lys Pro Phe Glu Ser Ile Asp Glu Gly Gln 
65                  70                  75                  80  


Val Thr His Asn Trp Asp Glu Val Asp Pro Asp Pro Asn Gln Leu Arg 
                85                  90                  95      


Trp Lys Pro Phe Glu Ile Pro Lys Ala Ser Gln Lys Lys Val Asp Phe 
            100                 105                 110         


Val Ser Gly Leu His Thr Leu Cys Gly Ala Gly Asp Ile Lys Ser Asn 
        115                 120                 125             


Asn Gly Leu Ala Ile His Ile Phe Leu Cys Asn Thr Ser Met Glu Asn 
    130                 135                 140                 


Arg Cys Phe Tyr Asn Ser Asp Gly Asp Phe Leu Ile Val Pro Gln Lys 
145                 150                 155                 160 


Gly Asn Leu Leu Ile Tyr Thr Glu Phe Gly Lys Met Leu Val Gln Pro 
                165                 170                 175     


Asn Glu Ile Cys Val Ile Gln Arg Gly Met Arg Phe Ser Ile Asp Val 
            180                 185                 190         


Phe Glu Glu Thr Arg Gly Tyr Ile Leu Glu Val Tyr Gly Val His Phe 
        195                 200                 205             


Glu Leu Pro Asp Leu Gly Pro Ile Gly Ala Asn Gly Leu Ala Asn Pro 
    210                 215                 220                 


Arg Asp Phe Leu Ile Pro Ile Ala Trp Tyr Glu Asp Arg Gln Val Pro 
225                 230                 235                 240 


Gly Gly Tyr Thr Val Ile Asn Lys Tyr Gln Gly Lys Leu Phe Ala Ala 
                245                 250                 255     


Lys Gln Asp Val Ser Pro Phe Asn Val Val Ala Trp His Gly Asn Tyr 
            260                 265                 270         


Thr Pro Tyr Lys Tyr Asn Leu Lys Asn Phe Met Val Ile Asn Ser Val 
        275                 280                 285             


Ala Phe Asp His Ala Asp Pro Ser Ile Phe Thr Val Leu Thr Ala Lys 
    290                 295                 300                 


Ser Val Arg Pro Gly Val Ala Ile Ala Asp Phe Val Ile Phe Pro Pro 
305                 310                 315                 320 


Arg Trp Gly Val Ala Asp Lys Thr Phe Arg Pro Pro Tyr Tyr His Arg 
                325                 330                 335     


Asn Cys Met Ser Glu Phe Met Gly Leu Ile Arg Gly His Tyr Glu Ala 
            340                 345                 350         


Lys Gln Gly Gly Phe Leu Pro Gly Gly Gly Ser Leu His Ser Thr Met 
        355                 360                 365             


Thr Pro His Gly Pro Asp Ala Asp Cys Phe Glu Lys Ala Ser Lys Val 
    370                 375                 380                 


Lys Leu Ala Pro Glu Arg Ile Ala Asp Gly Thr Met Ala Phe Met Phe 
385                 390                 395                 400 


Glu Ser Ser Leu Ser Leu Ala Val Thr Lys Trp Gly Leu Lys Ala Ser 
                405                 410                 415     


Arg Cys Leu Asp Glu Asn Tyr His Lys Cys Trp Glu Pro Leu Lys Ser 
            420                 425                 430         


His Phe Thr Pro Asn Ser Arg Asn Pro Ala Glu Pro Asn 
        435                 440                 445 


<210>  4960
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGFAC__Homo_sapiens__NP_001519

<400>  4960

Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Glu 
        355                 360                 365             


Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu Pro 
    370                 375                 380                 


Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu Pro 
                405                 410                 415     


Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe Cys 
            420                 425                 430         


Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His Cys 
        435                 440                 445             


Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly Gln 
    450                 455                 460                 


His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile Glu 
465                 470                 475                 480 


Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His 
                485                 490                 495     


Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala Thr 
            500                 505                 510         


Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser Thr 
        515                 520                 525             


Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu Asp 
    530                 535                 540                 


Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val Pro 
545                 550                 555                 560 


Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala Asp 
                565                 570                 575     


Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser Asp 
            580                 585                 590         


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn Gly 
        595                 600                 605             


Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly Arg 
    610                 615                 620                 


Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp Trp 
625                 630                 635                 640 


Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser 
                645                 650                 655 


<210>  4961
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGF__Homo_sapiens__NP_000592

<400>  4961

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             


<210>  4962
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGH1__Homo_sapiens__NP_057542

<400>  4962

Met Gly Glu Ala Gly Ala Gly Ala Gly Ala Ser Gly Gly Pro Glu Ala 
1               5                   10                  15      


Ser Pro Glu Ala Glu Val Val Lys Leu Leu Pro Phe Leu Ala Pro Gly 
            20                  25                  30          


Ala Arg Ala Asp Leu Gln Ala Ala Ala Val Arg His Val Leu Ala Leu 
        35                  40                  45              


Thr Gly Cys Gly Pro Gly Arg Ala Leu Leu Ala Gly Gln Ala Ala Leu 
    50                  55                  60                  


Leu Gln Ala Leu Met Glu Leu Ala Pro Ala Ser Ala Pro Ala Arg Asp 
65                  70                  75                  80  


Ala Ala Arg Ala Leu Val Asn Leu Ala Ala Asp Pro Gly Leu His Glu 
                85                  90                  95      


Thr Leu Leu Ala Ala Asp Pro Gly Leu Pro Ala Arg Leu Met Gly Arg 
            100                 105                 110         


Ala Leu Asp Pro Gln Trp Pro Trp Ala Glu Glu Ala Ala Ala Ala Leu 
        115                 120                 125             


Ala Asn Leu Ser Arg Glu Pro Ala Pro Cys Ala Ala Leu Met Ala Ala 
    130                 135                 140                 


Leu Ala Ala Ala Glu Pro Ala Asp Ser Gly Leu Glu Arg Leu Val Arg 
145                 150                 155                 160 


Ala Leu Cys Thr Pro Gly Tyr Asn Ala Arg Ala Pro Leu His Tyr Leu 
                165                 170                 175     


Ala Pro Leu Leu Ser Asn Leu Ser Gln Arg Pro Ala Ala Arg Ala Phe 
            180                 185                 190         


Leu Leu Asp Pro Asp Arg Cys Val Val Gln Arg Leu Leu Pro Leu Thr 
        195                 200                 205             


Gln Tyr Pro Asp Ser Ser Val Arg Arg Gly Gly Val Val Gly Thr Leu 
    210                 215                 220                 


Arg Asn Cys Cys Phe Glu His Arg His His Glu Trp Leu Leu Gly Pro 
225                 230                 235                 240 


Glu Val Asp Ile Leu Pro Phe Leu Leu Leu Pro Leu Ala Gly Pro Glu 
                245                 250                 255     


Asp Phe Ser Glu Glu Glu Met Glu Arg Leu Pro Val Asp Leu Gln Tyr 
            260                 265                 270         


Leu Pro Pro Asp Lys Gln Arg Glu Pro Asp Ala Asp Ile Arg Lys Met 
        275                 280                 285             


Leu Val Glu Ala Ile Met Leu Leu Thr Ala Thr Ala Pro Gly Arg Gln 
    290                 295                 300                 


Gln Val Arg Asp Gln Gly Ala Tyr Leu Ile Leu Arg Glu Leu His Ser 
305                 310                 315                 320 


Trp Glu Pro Glu Pro Asp Val Arg Thr Ala Cys Glu Lys Leu Ile Gln 
                325                 330                 335     


Val Leu Ile Gly Asp Glu Pro Glu Arg Gly Met Glu Asn Leu Leu Glu 
            340                 345                 350         


Val Gln Val Pro Glu Asp Val Glu Gln Gln Leu Gln Gln Leu Asp Cys 
        355                 360                 365             


Arg Glu Gln Glu Gln Leu Glu Arg Glu Leu Ala Pro Glu Pro Trp Val 
    370                 375                 380                 


Glu Arg Ala Thr Pro Thr 
385                 390 


<210>  4963
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGS__Homo_sapiens__NP_004703

<400>  4963

Met Gly Arg Gly Ser Gly Thr Phe Glu Arg Leu Leu Asp Lys Ala Thr 
1               5                   10                  15      


Ser Gln Leu Leu Leu Glu Thr Asp Trp Glu Ser Ile Leu Gln Ile Cys 
            20                  25                  30          


Asp Leu Ile Arg Gln Gly Asp Thr Gln Ala Lys Tyr Ala Val Asn Ser 
        35                  40                  45              


Ile Lys Lys Lys Val Asn Asp Lys Asn Pro His Val Ala Leu Tyr Ala 
    50                  55                  60                  


Leu Glu Val Met Glu Ser Val Val Lys Asn Cys Gly Gln Thr Val His 
65                  70                  75                  80  


Asp Glu Val Ala Asn Lys Gln Thr Met Glu Glu Leu Lys Asp Leu Leu 
                85                  90                  95      


Lys Arg Gln Val Glu Val Asn Val Arg Asn Lys Ile Leu Tyr Leu Ile 
            100                 105                 110         


Gln Ala Trp Ala His Ala Phe Arg Asn Glu Pro Lys Tyr Lys Val Val 
        115                 120                 125             


Gln Asp Thr Tyr Gln Ile Met Lys Val Glu Gly His Val Phe Pro Glu 
    130                 135                 140                 


Phe Lys Glu Ser Asp Ala Met Phe Ala Ala Glu Arg Ala Pro Asp Trp 
145                 150                 155                 160 


Val Asp Ala Glu Glu Cys His Arg Cys Arg Val Gln Phe Gly Val Met 
                165                 170                 175     


Thr Arg Lys His His Cys Arg Ala Cys Gly Gln Ile Phe Cys Gly Lys 
            180                 185                 190         


Cys Ser Ser Lys Tyr Ser Thr Ile Pro Lys Phe Gly Ile Glu Lys Glu 
        195                 200                 205             


Val Arg Val Cys Glu Pro Cys Tyr Glu Gln Leu Asn Arg Lys Ala Glu 
    210                 215                 220                 


Gly Lys Ala Thr Ser Thr Thr Glu Leu Pro Pro Glu Tyr Leu Thr Ser 
225                 230                 235                 240 


Pro Leu Ser Gln Gln Ser Gln Leu Pro Pro Lys Arg Asp Glu Thr Ala 
                245                 250                 255     


Leu Gln Glu Glu Glu Glu Leu Gln Leu Ala Leu Ala Leu Ser Gln Ser 
            260                 265                 270         


Glu Ala Glu Glu Lys Glu Arg Leu Arg Gln Lys Ser Thr Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Lys Ala Glu Pro Met Pro Ser Ala Ser Ser Ala Pro Pro Ala 
    290                 295                 300                 


Ser Ser Leu Tyr Ser Ser Pro Val Asn Ser Ser Ala Pro Leu Ala Glu 
305                 310                 315                 320 


Asp Ile Asp Pro Glu Leu Ala Arg Tyr Leu Asn Arg Asn Tyr Trp Glu 
                325                 330                 335     


Lys Lys Gln Glu Glu Ala Arg Lys Ser Pro Thr Pro Ser Ala Pro Val 
            340                 345                 350         


Pro Leu Thr Glu Pro Ala Ala Gln Pro Gly Glu Gly His Ala Ala Pro 
        355                 360                 365             


Thr Asn Val Val Glu Asn Pro Leu Pro Glu Thr Asp Ser Gln Pro Ile 
    370                 375                 380                 


Pro Pro Ser Gly Gly Pro Phe Ser Glu Pro Gln Phe His Asn Gly Glu 
385                 390                 395                 400 


Ser Glu Glu Ser His Glu Gln Phe Leu Lys Ala Leu Gln Asn Ala Val 
                405                 410                 415     


Thr Thr Phe Val Asn Arg Met Lys Ser Asn His Met Arg Gly Arg Ser 
            420                 425                 430         


Ile Thr Asn Asp Ser Ala Val Leu Ser Leu Phe Gln Ser Ile Asn Gly 
        435                 440                 445             


Met His Pro Gln Leu Leu Glu Leu Leu Asn Gln Leu Asp Glu Arg Arg 
    450                 455                 460                 


Leu Tyr Tyr Glu Gly Leu Gln Asp Lys Leu Ala Gln Ile Arg Asp Ala 
465                 470                 475                 480 


Arg Gly Ala Leu Ser Ala Leu Arg Glu Glu His Arg Glu Lys Leu Arg 
                485                 490                 495     


Arg Ala Ala Glu Glu Ala Glu Arg Gln Arg Gln Ile Gln Leu Ala Gln 
            500                 505                 510         


Lys Leu Glu Ile Met Arg Gln Lys Lys Gln Glu Tyr Leu Glu Val Gln 
        515                 520                 525             


Arg Gln Leu Ala Ile Gln Arg Leu Gln Glu Gln Glu Lys Glu Arg Gln 
    530                 535                 540                 


Met Arg Leu Glu Gln Gln Lys Gln Thr Val Gln Met Arg Ala Gln Met 
545                 550                 555                 560 


Pro Ala Phe Pro Leu Pro Tyr Ala Gln Leu Gln Ala Met Pro Ala Ala 
                565                 570                 575     


Gly Gly Val Leu Tyr Gln Pro Ser Gly Pro Ala Ser Phe Pro Ser Thr 
            580                 585                 590         


Phe Ser Pro Ala Gly Ser Val Glu Gly Ser Pro Met His Gly Val Tyr 
        595                 600                 605             


Met Ser Gln Pro Ala Pro Ala Ala Gly Pro Tyr Pro Ser Met Pro Ser 
    610                 615                 620                 


Thr Ala Ala Asp Pro Ser Met Val Ser Ala Tyr Met Tyr Pro Ala Gly 
625                 630                 635                 640 


Ala Thr Gly Ala Gln Ala Ala Pro Gln Ala Gln Ala Gly Pro Thr Ala 
                645                 650                 655     


Ser Pro Ala Tyr Ser Ser Tyr Gln Pro Thr Pro Thr Ala Gly Tyr Gln 
            660                 665                 670         


Asn Val Ala Ser Gln Ala Pro Gln Ser Leu Pro Ala Ile Ser Gln Pro 
        675                 680                 685             


Pro Gln Ser Ser Thr Met Gly Tyr Met Gly Ser Gln Ser Val Ser Met 
    690                 695                 700                 


Gly Tyr Gln Pro Tyr Asn Met Gln Asn Leu Met Thr Thr Leu Pro Ser 
705                 710                 715                 720 


Gln Asp Ala Ser Leu Pro Pro Gln Gln Pro Tyr Ile Ala Gly Gln Gln 
                725                 730                 735     


Pro Met Tyr Gln Gln Met Ala Pro Ser Gly Gly Pro Pro Gln Gln Gln 
            740                 745                 750         


Pro Pro Val Ala Gln Gln Pro Gln Ala Gln Gly Pro Pro Ala Gln Gly 
        755                 760                 765             


Ser Glu Ala Gln Leu Ile Ser Phe Asp 
    770                 775         


<210>  4964
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HGSNAT__Homo_sapiens__NP_689632

<400>  4964

Met Ser Gly Ala Gly Arg Ala Leu Ala Ala Leu Leu Leu Ala Ala Ser 
1               5                   10                  15      


Val Leu Ser Ala Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp 
            20                  25                  30          


Ala Gln Ala Ala Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu 
        35                  40                  45              


Leu Lys Met Asp Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp 
    50                  55                  60                  


Thr Asn Leu Thr Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu 
65                  70                  75                  80  


Phe Gln Val Leu Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro 
                85                  90                  95      


Ser Ala Ala Ala Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln 
            100                 105                 110         


Leu Asn Asp Thr Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg 
        115                 120                 125             


Phe Gly Glu Phe Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn 
    130                 135                 140                 


Gly Val Ser Glu Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val 
145                 150                 155                 160 


Asp Ser Asn Leu Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val 
                165                 170                 175     


Ile Ile Val Ile Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe 
            180                 185                 190         


Asn Asn Trp Ile Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu 
        195                 200                 205             


Ile Asn Ser Glu Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly 
    210                 215                 220                 


Asp Val Gln Pro Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu 
225                 230                 235                 240 


Arg Ser Val Asp Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe 
                245                 250                 255     


Val Asn Tyr Gly Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp 
            260                 265                 270         


Asn Gly Leu Thr Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile 
        275                 280                 285             


Met Gly Ser Ser Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly 
    290                 295                 300                 


Cys Ser Lys Phe Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu 
305                 310                 315                 320 


Leu Ile Cys Ile Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly 
                325                 330                 335     


Pro Leu Ser Trp Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu 
            340                 345                 350         


Gly Val Thr Tyr Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys 
        355                 360                 365             


Pro Val Pro Glu His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg 
    370                 375                 380                 


Asp Ile Thr Ser Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu 
385                 390                 395                 400 


Gly Leu Trp Leu Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro 
                405                 410                 415     


Thr Gly Tyr Leu Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro 
            420                 425                 430         


Asn Cys Thr Gly Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly 
        435                 440                 445             


Asp Asp His Leu Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr 
    450                 455                 460                 


Glu Val Ala Tyr Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile 
465                 470                 475                 480 


Val Met Ala Phe Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr 
                485                 490                 495     


Lys Ala Arg Thr Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys 
            500                 505                 510         


Ile Leu Gly Leu Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu 
        515                 520                 525             


Gly Phe Ile Pro Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr 
    530                 535                 540                 


Thr Leu Ser Ser Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val 
545                 550                 555                 560 


Val Asp Val Lys Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly 
                565                 570                 575     


Met Asn Ser Ile Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr 
            580                 585                 590         


Phe Pro Phe Gln Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His 
        595                 600                 605             


Leu Thr Gln Asn Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr 
    610                 615                 620                 


Ile Leu Tyr Arg Lys Lys Ile Phe Trp Lys Ile 
625                 630                 635 


<210>  4965
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HHAT__Homo_sapiens__NP_001164035

<400>  4965

Met Leu Pro Arg Trp Glu Leu Ala Leu Tyr Leu Leu Ala Ser Leu Gly 
1               5                   10                  15      


Phe His Phe Tyr Ser Phe Tyr Glu Val Tyr Lys Val Ser Arg Glu His 
            20                  25                  30          


Glu Glu Glu Leu Asp Gln Glu Phe Glu Leu Glu Thr Asp Thr Leu Phe 
        35                  40                  45              


Gly Gly Leu Lys Lys Asp Ala Thr Asp Phe Glu Trp Ser Phe Trp Met 
    50                  55                  60                  


Glu Trp Gly Lys Gln Trp Leu Val Trp Leu Leu Leu Gly His Met Val 
65                  70                  75                  80  


Val Ser Gln Met Ala Thr Leu Leu Ala Arg Lys Met Gln Gln Gln Glu 
                85                  90                  95      


His Asp Ser Leu Lys Ala Ser Leu Cys Val Leu Ala Leu Gly Leu Gly 
            100                 105                 110         


Arg Leu Leu Cys Trp Trp Trp Leu Ala Glu Leu Met Ala His Leu Met 
        115                 120                 125             


Tyr Met His Ala Ile Tyr Ser Ser Ile Pro Leu Leu Glu Thr Val Ser 
    130                 135                 140                 


Cys Trp Thr Leu Gly Gly Leu Ala Leu Ala Gln Val Leu Phe Phe Tyr 
145                 150                 155                 160 


Val Lys Tyr Leu Val Leu Phe Gly Val Pro Ala Leu Leu Met Arg Leu 
                165                 170                 175     


Asp Gly Leu Thr Pro Pro Ala Leu Pro Arg Cys Val Ser Thr Met Phe 
            180                 185                 190         


Ser Phe Thr Gly Met Trp Arg Tyr Phe Asp Val Gly Leu His Asn Phe 
        195                 200                 205             


Leu Ile Arg Tyr Val Tyr Ile Pro Val Gly Gly Ser Gln His Gly Leu 
    210                 215                 220                 


Leu Gly Thr Leu Phe Ser Thr Ala Met Thr Phe Ala Phe Val Ser Tyr 
225                 230                 235                 240 


Trp His Gly Gly Tyr Asp Tyr Leu Trp Cys Trp Ala Ala Leu Asn Trp 
                245                 250                 255     


Leu Gly Val Thr Val Glu Asn Gly Val Arg Arg Leu Val Glu Thr Pro 
            260                 265                 270         


Cys Ile Gln Asp Ser Leu Ala Arg Tyr Phe Ser Pro Gln Ala Arg Arg 
        275                 280                 285             


Arg Phe His Ala Ala Leu Ala Ser Cys Ser Thr Ser Met Leu Ile Leu 
    290                 295                 300                 


Ser Asn Leu Val Phe Leu Gly Gly Asn Glu Val Gly Lys Thr Tyr Trp 
305                 310                 315                 320 


Asn Arg Ile Phe Ile Gln Gly Trp Pro Trp Val Thr Leu Ser Val Leu 
                325                 330                 335     


Gly Phe Leu Tyr Cys Tyr Ser His Val Gly Ile Ala Trp Ala Gln Thr 
            340                 345                 350         


Tyr Ala Thr Asp 
        355     


<210>  4966
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HHATL__Homo_sapiens__NP_065758

<400>  4966

Met Gly Ile Lys Thr Ala Leu Pro Ala Ala Glu Leu Gly Leu Tyr Ser 
1               5                   10                  15      


Leu Val Leu Ser Gly Ala Leu Ala Tyr Ala Gly Arg Gly Leu Leu Glu 
            20                  25                  30          


Ala Ser Gln Asp Gly Ala His Arg Lys Ala Phe Arg Glu Ser Val Arg 
        35                  40                  45              


Pro Gly Trp Glu Tyr Ile Gly Arg Lys Met Asp Val Ala Asp Phe Glu 
    50                  55                  60                  


Trp Val Met Trp Phe Thr Ser Phe Arg Asn Val Ile Ile Phe Ala Leu 
65                  70                  75                  80  


Ser Gly His Val Leu Phe Ala Lys Leu Cys Thr Met Val Ala Pro Lys 
                85                  90                  95      


Leu Arg Ser Trp Met Tyr Ala Val Tyr Gly Ala Leu Ala Val Met Gly 
            100                 105                 110         


Thr Met Gly Pro Trp Tyr Leu Leu Leu Leu Leu Gly His Cys Val Gly 
        115                 120                 125             


Leu Tyr Val Ala Ser Leu Leu Gly Gln Pro Trp Leu Cys Leu Gly Leu 
    130                 135                 140                 


Gly Leu Ala Ser Leu Ala Ser Phe Lys Met Asp Pro Leu Ile Ser Trp 
145                 150                 155                 160 


Gln Ser Gly Phe Val Thr Gly Thr Phe Asp Leu Gln Glu Val Leu Phe 
                165                 170                 175     


His Gly Gly Ser Ser Phe Thr Val Leu Arg Cys Thr Ser Phe Ala Leu 
            180                 185                 190         


Glu Ser Cys Ala His Pro Asp Arg His Tyr Ser Leu Ala Asp Leu Leu 
        195                 200                 205             


Lys Tyr Asn Phe Tyr Leu Pro Phe Phe Phe Phe Gly Pro Ile Met Thr 
    210                 215                 220                 


Phe Asp Arg Phe His Ala Gln Val Ser Gln Val Glu Pro Val Arg Arg 
225                 230                 235                 240 


Glu Gly Glu Leu Trp His Ile Arg Ala Gln Ala Gly Leu Ser Val Val 
                245                 250                 255     


Ala Ile Met Ala Val Asp Ile Phe Phe His Phe Phe Tyr Ile Leu Thr 
            260                 265                 270         


Ile Pro Ser Asp Leu Lys Phe Ala Asn Arg Leu Pro Asp Ser Ala Leu 
        275                 280                 285             


Ala Gly Leu Ala Tyr Ser Asn Leu Val Tyr Asp Trp Val Lys Ala Ala 
    290                 295                 300                 


Val Leu Phe Gly Val Val Asn Thr Val Ala Cys Leu Asp His Leu Asp 
305                 310                 315                 320 


Pro Pro Gln Pro Pro Lys Cys Ile Thr Ala Leu Tyr Val Phe Ala Glu 
                325                 330                 335     


Thr His Phe Asp Arg Gly Ile Asn Asp Trp Leu Cys Lys Tyr Val Tyr 
            340                 345                 350         


Asn His Ile Gly Gly Glu His Ser Ala Val Ile Pro Glu Leu Ala Ala 
        355                 360                 365             


Thr Val Ala Thr Phe Ala Ile Thr Thr Leu Trp Leu Gly Pro Cys Asp 
    370                 375                 380                 


Ile Val Tyr Leu Trp Ser Phe Leu Asn Cys Phe Gly Leu Asn Phe Glu 
385                 390                 395                 400 


Leu Trp Met Gln Lys Leu Ala Glu Trp Gly Pro Leu Ala Arg Ile Glu 
                405                 410                 415     


Ala Ser Leu Ser Val Gln Met Ser Arg Arg Val Arg Ala Leu Phe Gly 
            420                 425                 430         


Ala Met Asn Phe Trp Ala Ile Ile Met Tyr Asn Leu Val Ser Leu Asn 
        435                 440                 445             


Ser Leu Lys Phe Thr Glu Leu Val Ala Arg Arg Leu Leu Leu Thr Gly 
    450                 455                 460                 


Phe Pro Gln Thr Thr Leu Ser Ile Leu Phe Val Thr Tyr Cys Gly Val 
465                 470                 475                 480 


Gln Leu Val Lys Glu Arg Glu Arg Thr Leu Ala Leu Glu Glu Glu Gln 
                485                 490                 495     


Lys Gln Asp Lys Glu Lys Pro Glu 
            500                 


<210>  4967
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HHEX__Homo_sapiens__NP_002720

<400>  4967

Met Gln Tyr Pro His Pro Gly Pro Ala Ala Gly Ala Val Gly Val Pro 
1               5                   10                  15      


Leu Tyr Ala Pro Thr Pro Leu Leu Gln Pro Ala His Pro Thr Pro Phe 
            20                  25                  30          


Tyr Ile Glu Asp Ile Leu Gly Arg Gly Pro Ala Ala Pro Thr Pro Ala 
        35                  40                  45              


Pro Thr Leu Pro Ser Pro Asn Ser Ser Phe Thr Ser Leu Val Ser Pro 
    50                  55                  60                  


Tyr Arg Thr Pro Val Tyr Glu Pro Thr Pro Ile His Pro Ala Phe Ser 
65                  70                  75                  80  


His His Ser Ala Ala Ala Leu Ala Ala Ala Tyr Gly Pro Gly Gly Phe 
                85                  90                  95      


Gly Gly Pro Leu Tyr Pro Phe Pro Arg Thr Val Asn Asp Tyr Thr His 
            100                 105                 110         


Ala Leu Leu Arg His Asp Pro Leu Gly Lys Pro Leu Leu Trp Ser Pro 
        115                 120                 125             


Phe Leu Gln Arg Pro Leu His Lys Arg Lys Gly Gly Gln Val Arg Phe 
    130                 135                 140                 


Ser Asn Asp Gln Thr Ile Glu Leu Glu Lys Lys Phe Glu Thr Gln Lys 
145                 150                 155                 160 


Tyr Leu Ser Pro Pro Glu Arg Lys Arg Leu Ala Lys Met Leu Gln Leu 
                165                 170                 175     


Ser Glu Arg Gln Val Lys Thr Trp Phe Gln Asn Arg Arg Ala Lys Trp 
            180                 185                 190         


Arg Arg Leu Lys Gln Glu Asn Pro Gln Ser Asn Lys Lys Glu Glu Leu 
        195                 200                 205             


Glu Ser Leu Asp Ser Ser Cys Asp Gln Arg Gln Asp Leu Pro Ser Glu 
    210                 215                 220                 


Gln Asn Lys Gly Ala Ser Leu Asp Ser Ser Gln Cys Ser Pro Ser Pro 
225                 230                 235                 240 


Ala Ser Gln Glu Asp Leu Glu Ser Glu Ile Ser Glu Asp Ser Asp Gln 
                245                 250                 255     


Glu Val Asp Ile Glu Gly Asp Lys Ser Tyr Phe Asn Ala Gly 
            260                 265                 270 


<210>  4968
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HHIP__Homo_sapiens__NP_071920

<400>  4968

Met Leu Lys Met Leu Ser Phe Lys Leu Leu Leu Leu Ala Val Ala Leu 
1               5                   10                  15      


Gly Phe Phe Glu Gly Asp Ala Lys Phe Gly Glu Arg Asn Glu Gly Ser 
            20                  25                  30          


Gly Ala Arg Arg Arg Arg Cys Leu Asn Gly Asn Pro Pro Lys Arg Leu 
        35                  40                  45              


Lys Arg Arg Asp Arg Arg Met Met Ser Gln Leu Glu Leu Leu Ser Gly 
    50                  55                  60                  


Gly Glu Met Leu Cys Gly Gly Phe Tyr Pro Arg Leu Ser Cys Cys Leu 
65                  70                  75                  80  


Arg Ser Asp Ser Pro Gly Leu Gly Arg Leu Glu Asn Lys Ile Phe Ser 
                85                  90                  95      


Val Thr Asn Asn Thr Glu Cys Gly Lys Leu Leu Glu Glu Ile Lys Cys 
            100                 105                 110         


Ala Leu Cys Ser Pro His Ser Gln Ser Leu Phe His Ser Pro Glu Arg 
        115                 120                 125             


Glu Val Leu Glu Arg Asp Leu Val Leu Pro Leu Leu Cys Lys Asp Tyr 
    130                 135                 140                 


Cys Lys Glu Phe Phe Tyr Thr Cys Arg Gly His Ile Pro Gly Phe Leu 
145                 150                 155                 160 


Gln Thr Thr Ala Asp Glu Phe Cys Phe Tyr Tyr Ala Arg Lys Asp Gly 
                165                 170                 175     


Gly Leu Cys Phe Pro Asp Phe Pro Arg Lys Gln Val Arg Gly Pro Ala 
            180                 185                 190         


Ser Asn Tyr Leu Asp Gln Met Glu Glu Tyr Asp Lys Val Glu Glu Ile 
        195                 200                 205             


Ser Arg Lys His Lys His Asn Cys Phe Cys Ile Gln Glu Val Val Ser 
    210                 215                 220                 


Gly Leu Arg Gln Pro Val Gly Ala Leu His Ser Gly Asp Gly Ser Gln 
225                 230                 235                 240 


Arg Leu Phe Ile Leu Glu Lys Glu Gly Tyr Val Lys Ile Leu Thr Pro 
                245                 250                 255     


Glu Gly Glu Ile Phe Lys Glu Pro Tyr Leu Asp Ile His Lys Leu Val 
            260                 265                 270         


Gln Ser Gly Ile Lys Gly Gly Asp Glu Arg Gly Leu Leu Ser Leu Ala 
        275                 280                 285             


Phe His Pro Asn Tyr Lys Lys Asn Gly Lys Leu Tyr Val Ser Tyr Thr 
    290                 295                 300                 


Thr Asn Gln Glu Arg Trp Ala Ile Gly Pro His Asp His Ile Leu Arg 
305                 310                 315                 320 


Val Val Glu Tyr Thr Val Ser Arg Lys Asn Pro His Gln Val Asp Leu 
                325                 330                 335     


Arg Thr Ala Arg Val Phe Leu Glu Val Ala Glu Leu His Arg Lys His 
            340                 345                 350         


Leu Gly Gly Gln Leu Leu Phe Gly Pro Asp Gly Phe Leu Tyr Ile Ile 
        355                 360                 365             


Leu Gly Asp Gly Met Ile Thr Leu Asp Asp Met Glu Glu Met Asp Gly 
    370                 375                 380                 


Leu Ser Asp Phe Thr Gly Ser Val Leu Arg Leu Asp Val Asp Thr Asp 
385                 390                 395                 400 


Met Cys Asn Val Pro Tyr Ser Ile Pro Arg Ser Asn Pro His Phe Asn 
                405                 410                 415     


Ser Thr Asn Gln Pro Pro Glu Val Phe Ala His Gly Leu His Asp Pro 
            420                 425                 430         


Gly Arg Cys Ala Val Asp Arg His Pro Thr Asp Ile Asn Ile Asn Leu 
        435                 440                 445             


Thr Ile Leu Cys Ser Asp Ser Asn Gly Lys Asn Arg Ser Ser Ala Arg 
    450                 455                 460                 


Ile Leu Gln Ile Ile Lys Gly Lys Asp Tyr Glu Ser Glu Pro Ser Leu 
465                 470                 475                 480 


Leu Glu Phe Lys Pro Phe Ser Asn Gly Pro Leu Val Gly Gly Phe Val 
                485                 490                 495     


Tyr Arg Gly Cys Gln Ser Glu Arg Leu Tyr Gly Ser Tyr Val Phe Gly 
            500                 505                 510         


Asp Arg Asn Gly Asn Phe Leu Thr Leu Gln Gln Ser Pro Val Thr Lys 
        515                 520                 525             


Gln Trp Gln Glu Lys Pro Leu Cys Leu Gly Thr Ser Gly Ser Cys Arg 
    530                 535                 540                 


Gly Tyr Phe Ser Gly His Ile Leu Gly Phe Gly Glu Asp Glu Leu Gly 
545                 550                 555                 560 


Glu Val Tyr Ile Leu Ser Ser Ser Lys Ser Met Thr Gln Thr His Asn 
                565                 570                 575     


Gly Lys Leu Tyr Lys Ile Val Asp Pro Lys Arg Pro Leu Met Pro Glu 
            580                 585                 590         


Glu Cys Arg Ala Thr Val Gln Pro Ala Gln Thr Leu Thr Ser Glu Cys 
        595                 600                 605             


Ser Arg Leu Cys Arg Asn Gly Tyr Cys Thr Pro Thr Gly Lys Cys Cys 
    610                 615                 620                 


Cys Ser Pro Gly Trp Glu Gly Asp Phe Cys Arg Thr Ala Lys Cys Glu 
625                 630                 635                 640 


Pro Ala Cys Arg His Gly Gly Val Cys Val Arg Pro Asn Lys Cys Leu 
                645                 650                 655     


Cys Lys Lys Gly Tyr Leu Gly Pro Gln Cys Glu Gln Val Asp Arg Asn 
            660                 665                 670         


Ile Arg Arg Val Thr Arg Ala Gly Ile Leu Asp Gln Ile Ile Asp Met 
        675                 680                 685             


Thr Ser Tyr Leu Leu Asp Leu Thr Ser Tyr Ile Val 
    690                 695                 700 


<210>  4969
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HHIPL1__Homo_sapiens__NP_001120730

<400>  4969

Met Ala Arg Ala Arg Ala Gly Ala Leu Leu Ala Leu Trp Val Leu Gly 
1               5                   10                  15      


Ala Ala Ala His Pro Gln Cys Leu Asp Phe Arg Pro Pro Phe Arg Pro 
            20                  25                  30          


Thr Gln Pro Leu Arg Leu Cys Ala Gln Tyr Ser Asp Phe Gly Cys Cys 
        35                  40                  45              


Asp Glu Gly Arg Asp Ala Glu Leu Thr Arg Arg Phe Trp Ala Leu Ala 
    50                  55                  60                  


Ser Arg Val Asp Ala Ala Glu Trp Ala Ala Cys Ala Gly Tyr Ala Arg 
65                  70                  75                  80  


Asp Leu Leu Cys Gln Glu Cys Ser Pro Tyr Ala Ala His Leu Tyr Asp 
                85                  90                  95      


Ala Glu Asp Pro Phe Thr Pro Leu Arg Thr Val Pro Gly Leu Cys Gln 
            100                 105                 110         


Asp Tyr Cys Leu Asp Met Trp His Lys Cys Arg Gly Leu Phe Arg His 
        115                 120                 125             


Leu Ser Thr Asp Gln Glu Leu Trp Ala Leu Glu Gly Asn Leu Ala Arg 
    130                 135                 140                 


Phe Cys Arg Tyr Leu Ser Leu Asp Asp Thr Asp Tyr Cys Phe Pro Tyr 
145                 150                 155                 160 


Leu Leu Val Asn Lys Asn Leu Asn Ser Asn Leu Gly His Val Val Ala 
                165                 170                 175     


Asp Ala Lys Gly Cys Leu Gln Leu Cys Leu Glu Glu Val Ala Asn Gly 
            180                 185                 190         


Leu Arg Asn Pro Val Ala Met Val His Ala Arg Asp Gly Thr His Arg 
        195                 200                 205             


Phe Phe Val Ala Glu Gln Val Gly Leu Val Trp Ala Tyr Leu Pro Asp 
    210                 215                 220                 


Arg Ser Arg Leu Gly Lys Pro Phe Leu Asn Ile Ser Arg Val Val Leu 
225                 230                 235                 240 


Thr Ser Pro Trp Glu Gly Asp Glu Arg Gly Phe Leu Gly Ile Ala Phe 
                245                 250                 255     


His Pro Ser Phe Gln His Asn Arg Arg Leu Tyr Val Tyr Tyr Ser Val 
            260                 265                 270         


Gly Ile Arg Ser Ser Glu Trp Ile Arg Ile Ser Glu Phe Arg Val Ser 
        275                 280                 285             


Glu Asp Asp Glu Asn Ala Val Asp His Ser Ser Glu Arg Ile Ile Leu 
    290                 295                 300                 


Glu Val Lys Glu Pro Ala Ser Asn His Asn Gly Gly Gln Leu Leu Phe 
305                 310                 315                 320 


Gly Asp Asp Gly Tyr Leu Tyr Ile Phe Thr Gly Asp Gly Gly Met Ala 
                325                 330                 335     


Gly Asp Pro Phe Gly Thr Phe Gly Asn Ala Gln Asn Lys Ser Ala Leu 
            340                 345                 350         


Leu Gly Lys Val Leu Arg Ile Asp Val Asp Arg Lys Glu Arg Gly Leu 
        355                 360                 365             


Pro Tyr Gly Ile Pro Pro Asp Asn Pro Phe Val Gly Asp Pro Ala Ala 
    370                 375                 380                 


Gln Pro Glu Val Tyr Ala Leu Gly Val Arg Asn Met Trp Arg Cys Ser 
385                 390                 395                 400 


Phe Asp Arg Gly Asp Pro Ser Ser Gly Thr Gly Arg Gly Arg Leu Phe 
                405                 410                 415     


Cys Gly Asp Val Gly Gln Asn Lys Phe Glu Glu Val Asp Val Val Glu 
            420                 425                 430         


Arg Gly Gly Asn Tyr Gly Trp Arg Ala Arg Glu Gly Phe Glu Cys Tyr 
        435                 440                 445             


Asp Arg Ser Leu Cys Ala Asn Thr Ser Leu Asn Asp Leu Leu Pro Ile 
    450                 455                 460                 


Phe Ala Tyr Pro His Thr Val Gly Lys Ser Val Thr Gly Gly Tyr Val 
465                 470                 475                 480 


Tyr Arg Gly Cys Glu Tyr Pro Asn Leu Asn Gly Leu Tyr Ile Phe Gly 
                485                 490                 495     


Asp Phe Met Ser Gly Arg Leu Met Ser Leu Gln Glu Asn Pro Gly Thr 
            500                 505                 510         


Gly Gln Trp Gln Tyr Ser Glu Ile Cys Met Gly His Gly Gln Thr Cys 
        515                 520                 525             


Glu Phe Pro Gly Leu Ile Asn Asn Tyr Tyr Pro Tyr Ile Ile Ser Phe 
    530                 535                 540                 


Gly Glu Asp Glu Ala Gly Glu Leu Tyr Phe Met Ser Thr Gly Glu Pro 
545                 550                 555                 560 


Ser Ala Thr Ala Pro Arg Gly Val Val Tyr Lys Ile Ile Asp Ala Ser 
                565                 570                 575     


Arg Arg Ala Pro Pro Gly Lys Cys Gln Ile Gln Pro Ala Gln Val Lys 
            580                 585                 590         


Ile Arg Ser Arg Leu Ile Pro Phe Val Pro Lys Glu Lys Phe Ile Pro 
        595                 600                 605             


Lys Thr Arg Ser Thr Pro Arg Pro Thr Ala Arg Ala Pro Thr Arg Ala 
    610                 615                 620                 


Pro Arg Arg Gly Arg Pro Thr Ala Ala Pro Pro Ala Pro Thr Pro Arg 
625                 630                 635                 640 


Pro Ala Arg Pro Thr Gln Gln Pro Gly Ser Arg Arg Gly Gly Gly Arg 
                645                 650                 655     


Arg Arg Gly Arg Leu Asn Ser Ala Ser Arg Ala Phe Arg Asp Gly Glu 
            660                 665                 670         


Val Arg Leu Val Arg Pro Ala Gly Leu Ser Ser Gly Ser Gly Arg Val 
        675                 680                 685             


Glu Val Phe Val Gly Gly Arg Trp Gly Thr Val Cys Asp Asp Ser Trp 
    690                 695                 700                 


Asn Ile Ser Gly Ala Ala Val Val Cys Arg Gln Leu Gly Phe Ala Tyr 
705                 710                 715                 720 


Ala Val Arg Ala Val Lys Arg Ala Glu Phe Gly Gln Gly Gly Ser Leu 
                725                 730                 735     


Pro Ile Leu Leu Asp Asp Val Arg Cys Ala Gly Trp Glu Arg Asn Leu 
            740                 745                 750         


Leu Glu Cys Gln His Asn Gly Val Gly Thr His Asn Cys Glu His Asp 
        755                 760                 765             


Glu Asp Ala Gly Val Val Cys Ser His Gln Asn Pro Asp Leu 
    770                 775                 780         


<210>  4970
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HHLA1__Homo_sapiens__NP_001138567

<400>  4970

Met Leu Gly Phe Leu Ser Arg Gly Pro Ser Met Lys Leu Cys Met Gly 
1               5                   10                  15      


Leu Ala Cys Val Leu Ser Leu Trp Asn Thr Val Ser Gly Ile Lys Gly 
            20                  25                  30          


Glu Ala Lys Lys Glu Lys Gly Met Thr Phe Leu Pro Thr Thr Val Ser 
        35                  40                  45              


Gly Leu Arg Glu Glu Glu Arg Lys Glu Lys Gly Val Ala Phe Leu Ala 
    50                  55                  60                  


Thr Thr Glu Leu Pro Ala Arg Ser Ile Asp Leu Ser Ala Leu Asn Leu 
65                  70                  75                  80  


Thr Glu Leu Val Asn Gly Met Leu Ser Arg Ala Leu Lys Asp Ser Lys 
                85                  90                  95      


Lys Phe Phe Ser Leu Leu Ser Val Thr Ser Tyr Ser Ser Phe Ala Phe 
            100                 105                 110         


His Lys Phe Ser Val Ala Val Tyr Asn Ile Ser Asn Leu Lys Thr Val 
        115                 120                 125             


Asp Pro Ala Lys Phe Pro Thr Arg Tyr Cys Tyr Cys Leu Asn Asn Arg 
    130                 135                 140                 


Thr Asn Asp Leu Ser Asp Phe Thr Ala Leu Leu Val Asp Ile Ile Gly 
145                 150                 155                 160 


Asn Ser Thr Ser Tyr Leu Thr Glu Ile Phe Lys Ser Thr Ser Ile Leu 
                165                 170                 175     


Ser Val Asn Gln Ser Asn Glu Ser Asp Cys Ile Phe Ile Cys Val Met 
            180                 185                 190         


Thr Gly Lys Ser Gly Arg Asn Leu Ser Asp Phe Trp Glu Ile Glu Glu 
        195                 200                 205             


Lys Tyr Pro Ile Ile Asn Tyr Thr Phe Thr Ser Gly Leu Ser Gly Val 
    210                 215                 220                 


Leu Gly Ala Ala Thr Arg Gly Thr Ala Arg Thr Ser Lys Pro Thr Thr 
225                 230                 235                 240 


Lys Ser Gln Lys Thr Leu Pro Ser Thr Ser Pro Gly His Trp Thr Gln 
                245                 250                 255     


Ser Thr Pro Trp Ala Ser Ala Leu Arg Ser Ser Pro Trp Thr Glu Thr 
            260                 265                 270         


Ala Ala Pro Ser Glu Thr Glu Glu Thr Leu Asn Thr Gly Arg Pro Pro 
        275                 280                 285             


Glu Leu Pro Ala Arg Ala Thr Ala Thr Trp Phe Ser Ala Ser His Thr 
    290                 295                 300                 


Leu Pro Ala Leu Ala Thr Arg Arg Val Ala Arg Thr Gln Trp Leu Thr 
305                 310                 315                 320 


Ala Asp Arg Gln Thr Trp Ala Ser Ile Ser Ser Val Pro Trp Ala Gln 
                325                 330                 335     


Thr Ile Ser Glu Lys Lys Pro Gly Gly Ser Leu Trp Glu Thr Arg Ser 
            340                 345                 350         


Ser Pro Pro Thr Thr Ala Gly Thr Glu Glu Ala Met Asn Thr Thr Ser 
        355                 360                 365             


Leu Leu Ala Pro Ala Ala Glu Ile Met Ala Thr Pro Gly Ser Pro Ser 
    370                 375                 380                 


Gln Ala Ser Pro Thr Leu Gly Ala Phe Thr His Gly Thr Gln Thr Pro 
385                 390                 395                 400 


Ser Pro Thr Lys Ala Thr Ala Pro Arg Tyr Pro Gln Thr Gly Asp Leu 
                405                 410                 415     


Ser Ala Glu Trp Pro Phe Thr Ala Gly Glu Glu Pro Val Leu Val Pro 
            420                 425                 430         


Arg Pro His Gln Val Ser Arg Cys Pro Gln Pro Leu Phe Lys Val Gly 
        435                 440                 445             


Ala Met Ala Ala Ala Pro Leu Thr Leu Ala Ile Gln Arg Leu Asn Pro 
    450                 455                 460                 


Cys Leu Met Glu Leu Cys Gln Phe Phe Gln Gln Cys Leu Cys Met Ser 
465                 470                 475                 480 


Gln Arg Ser Pro Arg Thr Glu Asp Met Arg Tyr Cys Leu Glu Tyr Tyr 
                485                 490                 495     


Ser Trp Phe Leu Lys Asn Ala Thr Tyr Ile Cys Gln Arg Val Lys Arg 
            500                 505                 510         


Val Ser His Ser His Thr Leu Lys Gln Lys Cys Leu Glu Asn Ile Cys 
        515                 520                 525             


Lys Ser Val 
    530     


<210>  4971
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HHLA2__Homo_sapiens__NP_001269487

<400>  4971

Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala Pro 
    370                 375                 380                 


Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
385                 390                 395         


<210>  4972
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIAT1__Homo_sapiens__XP_011540259

<400>  4972

Met Thr Gln Gly Lys Lys Lys Lys Arg Ala Ala Asn Arg Ser Ile Met 
1               5                   10                  15      


Leu Ala Lys Lys Ile Ile Ile Lys Asp Gly Gly Thr Pro Gln Gly Ile 
            20                  25                  30          


Gly Ser Pro Ser Val Tyr His Ala Val Ile Val Ile Phe Leu Glu Phe 
        35                  40                  45              


Phe Ala Trp Gly Leu Leu Thr Ala Pro Thr Leu Val Val Leu His Glu 
    50                  55                  60                  


Thr Phe Pro Lys His Thr Phe Leu Met Asn Gly Leu Ile Gln Gly Val 
65                  70                  75                  80  


Lys Gly Leu Leu Ser Phe Leu Ser Ala Pro Leu Ile Gly Ala Leu Ser 
                85                  90                  95      


Asp Val Trp Gly Arg Lys Ser Phe Leu Leu Leu Thr Val Phe Phe Thr 
            100                 105                 110         


Cys Ala Pro Ile Pro Leu Met Lys Ile Ser Pro Trp Trp Tyr Phe Ala 
        115                 120                 125             


Val Ile Ser Val Ser Gly Val Phe Ala Val Thr Phe Ser Val Val Phe 
    130                 135                 140                 


Ala Tyr Val Ala Asp Ile Thr Gln Glu His Glu Arg Ser Met Ala Tyr 
145                 150                 155                 160 


Gly Leu Val Ser Ala Thr Phe Ala Ala Ser Leu Val Thr Ser Pro Ala 
                165                 170                 175     


Ile Gly Ala Tyr Leu Gly Arg Val Tyr Gly Asp Ser Leu Val Val Val 
            180                 185                 190         


Leu Ala Thr Ala Ile Ala Leu Leu Asp Ile Cys Phe Ile Leu Val Ala 
        195                 200                 205             


Val Pro Glu Ser Leu Pro Glu Lys Met Arg Pro Ala Ser Trp Gly Ala 
    210                 215                 220                 


Pro Ile Ser Trp Glu Gln Ala Asp Pro Phe Ala Ile Met Lys Phe Ser 
225                 230                 235                 240 


Pro Glu Ser Val Ala Ala Phe Ile Ala Val Leu Gly Ile Leu Ser Ile 
                245                 250                 255     


Ile Ala Gln Thr Ile Val Leu Ser Leu Leu Met Arg Ser Ile Gly Asn 
            260                 265                 270         


Lys Asn Thr Ile Leu Leu Gly Leu Gly Phe Gln Ile Leu Gln Leu Ala 
        275                 280                 285             


Trp Tyr Gly Phe Gly Ser Glu Pro Trp Met Met Trp Ala Ala Gly Ala 
    290                 295                 300                 


Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala Val Ser Ala Leu Val 
305                 310                 315                 320 


Ser Arg Thr Ala Asp Ala Asp Gln Gln Gly Val Val Gln Gly Met Ile 
                325                 330                 335     


Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr Gly 
            340                 345                 350         


Phe Ile Phe Tyr Ile Phe His Val Glu Leu Lys Glu Leu Pro Ile Thr 
        355                 360                 365             


Gly Thr Asp Leu Gly Thr Asn Thr Ser Pro Gln His His Phe Glu Gln 
    370                 375                 380                 


Asn Ser Ile Ile Pro Gly Pro Pro Phe Leu Phe Gly Ala Cys Ser Val 
385                 390                 395                 400 


Leu Leu Ala Leu Leu Val Ala Leu Phe Ile Pro Glu His Thr Asn Leu 
                405                 410                 415     


Ser Leu Arg Ser Ser Ser Trp Arg Lys His Cys Gly Ser His Ser His 
            420                 425                 430         


Pro His Asn Thr Gln Ala Pro Gly Glu Ala Lys Glu Pro Leu Leu Gln 
        435                 440                 445             


Asp Thr Asn Val 
    450         


<210>  4973
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIBADH__Homo_sapiens__NP_689953

<400>  4973

Met Ala Ala Ser Leu Arg Leu Leu Gly Ala Ala Ser Gly Leu Arg Tyr 
1               5                   10                  15      


Trp Ser Arg Arg Leu Arg Pro Ala Ala Gly Ser Phe Ala Ala Val Cys 
            20                  25                  30          


Ser Arg Ser Val Ala Ser Lys Thr Pro Val Gly Phe Ile Gly Leu Gly 
        35                  40                  45              


Asn Met Gly Asn Pro Met Ala Lys Asn Leu Met Lys His Gly Tyr Pro 
    50                  55                  60                  


Leu Ile Ile Tyr Asp Val Phe Pro Asp Ala Cys Lys Glu Phe Gln Asp 
65                  70                  75                  80  


Ala Gly Glu Gln Val Val Ser Ser Pro Ala Asp Val Ala Glu Lys Ala 
                85                  90                  95      


Asp Arg Ile Ile Thr Met Leu Pro Thr Ser Ile Asn Ala Ile Glu Ala 
            100                 105                 110         


Tyr Ser Gly Ala Asn Gly Ile Leu Lys Lys Val Lys Lys Gly Ser Leu 
        115                 120                 125             


Leu Ile Asp Ser Ser Thr Ile Asp Pro Ala Val Ser Lys Glu Leu Ala 
    130                 135                 140                 


Lys Glu Val Glu Lys Met Gly Ala Val Phe Met Asp Ala Pro Val Ser 
145                 150                 155                 160 


Gly Gly Val Gly Ala Ala Arg Ser Gly Asn Leu Thr Phe Met Val Gly 
                165                 170                 175     


Gly Val Glu Asp Glu Phe Ala Ala Ala Gln Glu Leu Leu Gly Cys Met 
            180                 185                 190         


Gly Ser Asn Val Val Tyr Cys Gly Ala Val Gly Thr Gly Gln Ala Ala 
        195                 200                 205             


Lys Ile Cys Asn Asn Met Leu Leu Ala Ile Ser Met Ile Gly Thr Ala 
    210                 215                 220                 


Glu Ala Met Asn Leu Gly Ile Arg Leu Gly Leu Asp Pro Lys Leu Leu 
225                 230                 235                 240 


Ala Lys Ile Leu Asn Met Ser Ser Gly Arg Cys Trp Ser Ser Asp Thr 
                245                 250                 255     


Tyr Asn Pro Val Pro Gly Val Met Asp Gly Val Pro Ser Ala Asn Asn 
            260                 265                 270         


Tyr Gln Gly Gly Phe Gly Thr Thr Leu Met Ala Lys Asp Leu Gly Leu 
        275                 280                 285             


Ala Gln Asp Ser Ala Thr Ser Thr Lys Ser Pro Ile Leu Leu Gly Ser 
    290                 295                 300                 


Leu Ala His Gln Ile Tyr Arg Met Met Cys Ala Lys Gly Tyr Ser Lys 
305                 310                 315                 320 


Lys Asp Phe Ser Ser Val Phe Gln Phe Leu Arg Glu Glu Glu Thr Phe 
                325                 330                 335     


<210>  4974
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIBCH__Homo_sapiens__NP_055177

<400>  4974

Met Gly Gln Arg Glu Met Trp Arg Leu Met Ser Arg Phe Asn Ala Phe 
1               5                   10                  15      


Lys Arg Thr Asn Thr Ile Leu His His Leu Arg Met Ser Lys His Thr 
            20                  25                  30          


Asp Ala Ala Glu Glu Val Leu Leu Glu Lys Lys Gly Cys Thr Gly Val 
        35                  40                  45              


Ile Thr Leu Asn Arg Pro Lys Phe Leu Asn Ala Leu Thr Leu Asn Met 
    50                  55                  60                  


Ile Arg Gln Ile Tyr Pro Gln Leu Lys Lys Trp Glu Gln Asp Pro Glu 
65                  70                  75                  80  


Thr Phe Leu Ile Ile Ile Lys Gly Ala Gly Gly Lys Ala Phe Cys Ala 
                85                  90                  95      


Gly Gly Asp Ile Arg Val Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys 
            100                 105                 110         


Ile Ala Pro Val Phe Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val 
        115                 120                 125             


Gly Ser Cys Gln Lys Pro Tyr Val Ala Leu Ile His Gly Ile Thr Met 
    130                 135                 140                 


Gly Gly Gly Val Gly Leu Ser Val His Gly Gln Phe Arg Val Ala Thr 
145                 150                 155                 160 


Glu Lys Cys Leu Phe Ala Met Pro Glu Thr Ala Ile Gly Leu Phe Pro 
                165                 170                 175     


Asp Val Gly Gly Gly Tyr Phe Leu Pro Arg Leu Gln Gly Lys Leu Gly 
            180                 185                 190         


Tyr Phe Leu Ala Leu Thr Gly Phe Arg Leu Lys Gly Arg Asp Val Tyr 
        195                 200                 205             


Arg Ala Gly Ile Ala Thr His Phe Val Asp Ser Glu Lys Leu Ala Met 
    210                 215                 220                 


Leu Glu Glu Asp Leu Leu Ala Leu Lys Ser Pro Ser Lys Glu Asn Ile 
225                 230                 235                 240 


Ala Ser Val Leu Glu Asn Tyr His Thr Glu Ser Lys Ile Asp Arg Asp 
                245                 250                 255     


Lys Ser Phe Ile Leu Glu Glu His Met Asp Lys Ile Asn Ser Cys Phe 
            260                 265                 270         


Ser Ala Asn Thr Val Glu Glu Ile Ile Glu Asn Leu Gln Gln Asp Gly 
        275                 280                 285             


Ser Ser Phe Ala Leu Glu Gln Leu Lys Val Ile Asn Lys Met Ser Pro 
    290                 295                 300                 


Thr Ser Leu Lys Ile Thr Leu Arg Gln Leu Met Glu Gly Ser Ser Lys 
305                 310                 315                 320 


Thr Leu Gln Glu Val Leu Thr Met Glu Tyr Arg Leu Ser Gln Ala Cys 
                325                 330                 335     


Met Arg Gly His Asp Phe His Glu Gly Val Arg Ala Val Leu Ile Asp 
            340                 345                 350         


Lys Asp Gln Ser Pro Lys Trp Lys Pro Ala Asp Leu Lys Glu Val Thr 
        355                 360                 365             


Glu Glu Asp Leu Asn Asn His Phe Lys Ser Leu Gly Ser Ser Asp Leu 
    370                 375                 380                 


Lys Phe 
385     


<210>  4975
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIC1__Homo_sapiens__NP_001091672

<400>  4975

Met Thr Phe Pro Glu Ala Asp Ile Leu Leu Lys Ser Gly Glu Cys Ala 
1               5                   10                  15      


Gly Gln Thr Met Leu Asp Thr Met Glu Ala Pro Gly His Ser Arg Gln 
            20                  25                  30          


Leu Leu Leu Gln Leu Asn Asn Gln Arg Thr Lys Gly Phe Leu Cys Asp 
        35                  40                  45              


Val Ile Ile Val Val Gln Asn Ala Leu Phe Arg Ala His Lys Asn Val 
    50                  55                  60                  


Leu Ala Ala Ser Ser Ala Tyr Leu Lys Ser Leu Val Val His Asp Asn 
65                  70                  75                  80  


Leu Leu Asn Leu Asp His Asp Met Val Ser Pro Ala Val Phe Arg Leu 
                85                  90                  95      


Val Leu Asp Phe Ile Tyr Thr Gly Arg Leu Ala Asp Gly Ala Glu Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Val Ala Pro Gly Ala Glu Pro Ser Leu Gly Ala 
        115                 120                 125             


Val Leu Ala Ala Ala Ser Tyr Leu Gln Ile Pro Asp Leu Val Ala Leu 
    130                 135                 140                 


Cys Lys Lys Arg Leu Lys Arg His Gly Lys Tyr Cys His Leu Arg Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Tyr Ala Pro Tyr Gly Arg Pro Gly Arg 
                165                 170                 175     


Gly Leu Arg Ala Ala Thr Pro Val Ile Gln Ala Cys Tyr Pro Ser Pro 
            180                 185                 190         


Val Gly Pro Pro Pro Pro Pro Ala Ala Glu Pro Pro Ser Gly Pro Glu 
        195                 200                 205             


Ala Ala Val Asn Thr His Cys Ala Glu Leu Tyr Ala Ser Gly Pro Gly 
    210                 215                 220                 


Pro Ala Ala Ala Leu Cys Ala Ser Glu Arg Arg Cys Ser Pro Leu Cys 
225                 230                 235                 240 


Gly Leu Asp Leu Ser Lys Lys Ser Pro Pro Gly Ser Ala Ala Pro Glu 
                245                 250                 255     


Arg Pro Leu Ala Glu Arg Glu Leu Pro Pro Arg Pro Asp Ser Pro Pro 
            260                 265                 270         


Ser Ala Gly Pro Ala Ala Tyr Lys Glu Pro Pro Leu Ala Leu Pro Ser 
        275                 280                 285             


Leu Pro Pro Leu Pro Phe Gln Lys Leu Glu Glu Ala Ala Pro Pro Ser 
    290                 295                 300                 


Asp Pro Phe Arg Gly Gly Ser Gly Ser Pro Gly Pro Glu Pro Pro Gly 
305                 310                 315                 320 


Arg Pro Asp Gly Pro Ser Leu Leu Tyr Arg Trp Met Lys His Glu Pro 
                325                 330                 335     


Gly Leu Gly Ser Tyr Gly Asp Glu Leu Gly Arg Glu Arg Gly Ser Pro 
            340                 345                 350         


Ser Glu Arg Cys Glu Glu Arg Gly Gly Asp Ala Ala Val Ser Pro Gly 
        355                 360                 365             


Gly Pro Pro Leu Gly Leu Ala Pro Pro Pro Arg Tyr Pro Gly Ser Leu 
    370                 375                 380                 


Asp Gly Pro Gly Ala Gly Gly Asp Gly Asp Asp Tyr Lys Ser Ser Ser 
385                 390                 395                 400 


Glu Glu Thr Gly Ser Ser Glu Asp Pro Ser Pro Pro Gly Gly His Leu 
                405                 410                 415     


Glu Gly Tyr Pro Cys Pro His Leu Ala Tyr Gly Glu Pro Glu Ser Phe 
            420                 425                 430         


Gly Asp Asn Leu Tyr Val Cys Ile Pro Cys Gly Lys Gly Phe Pro Ser 
        435                 440                 445             


Ser Glu Gln Leu Asn Ala His Val Glu Ala His Val Glu Glu Glu Glu 
    450                 455                 460                 


Ala Leu Tyr Gly Arg Ala Glu Ala Ala Glu Val Ala Ala Gly Ala Ala 
465                 470                 475                 480 


Gly Leu Gly Pro Pro Phe Gly Gly Gly Gly Asp Lys Val Ala Gly Ala 
                485                 490                 495     


Pro Gly Gly Leu Gly Glu Leu Leu Arg Pro Tyr Arg Cys Ala Ser Cys 
            500                 505                 510         


Asp Lys Ser Tyr Lys Asp Pro Ala Thr Leu Arg Gln His Glu Lys Thr 
        515                 520                 525             


His Trp Leu Thr Arg Pro Tyr Pro Cys Thr Ile Cys Gly Lys Lys Phe 
    530                 535                 540                 


Thr Gln Arg Gly Thr Met Thr Arg His Met Arg Ser His Leu Gly Leu 
545                 550                 555                 560 


Lys Pro Phe Ala Cys Asp Ala Cys Gly Met Arg Phe Thr Arg Gln Tyr 
                565                 570                 575     


Arg Leu Thr Glu His Met Arg Ile His Ser Gly Glu Lys Pro Tyr Glu 
            580                 585                 590         


Cys Gln Val Cys Gly Gly Lys Phe Ala Gln Gln Arg Asn Leu Ile Ser 
        595                 600                 605             


His Met Lys Met His Ala Val Gly Gly Ala Ala Gly Ala Ala Gly Ala 
    610                 615                 620                 


Leu Ala Gly Leu Gly Gly Leu Pro Gly Val Pro Gly Pro Asp Gly Lys 
625                 630                 635                 640 


Gly Lys Leu Asp Phe Pro Glu Gly Val Phe Ala Val Ala Arg Leu Thr 
                645                 650                 655     


Ala Glu Gln Leu Ser Leu Lys Gln Gln Asp Lys Ala Ala Ala Ala Glu 
            660                 665                 670         


Leu Leu Ala Gln Thr Thr His Phe Leu His Asp Pro Lys Val Ala Leu 
        675                 680                 685             


Glu Ser Leu Tyr Pro Leu Ala Lys Phe Thr Ala Glu Leu Gly Leu Ser 
    690                 695                 700                 


Pro Asp Lys Ala Ala Glu Val Leu Ser Gln Gly Ala His Leu Ala Ala 
705                 710                 715                 720 


Gly Pro Asp Gly Arg Thr Ile Asp Arg Phe Ser Pro Thr 
                725                 730             


<210>  4976
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIC2__Homo_sapiens__NP_055909

<400>  4976

Met Val Ser Gly Pro Leu Ala Leu Arg Trp Cys Ala Trp Ala Gly Arg 
1               5                   10                  15      


Gly Asp Met Gly Pro Asp Met Glu Leu Pro Ser His Ser Lys Gln Leu 
            20                  25                  30          


Leu Leu Gln Leu Asn Gln Gln Arg Thr Lys Gly Phe Leu Cys Asp Val 
        35                  40                  45              


Ile Ile Met Val Glu Asn Ser Ile Phe Arg Ala His Lys Asn Val Leu 
    50                  55                  60                  


Ala Ala Ser Ser Ile Tyr Phe Lys Ser Leu Val Leu His Asp Asn Leu 
65                  70                  75                  80  


Ile Asn Leu Asp Thr Asp Met Val Ser Ser Thr Val Phe Gln Gln Ile 
                85                  90                  95      


Leu Asp Phe Ile Tyr Thr Gly Lys Leu Leu Pro Ser Asp Gln Pro Ala 
            100                 105                 110         


Glu Pro Asn Phe Ser Thr Leu Leu Thr Ala Ala Ser Tyr Leu Gln Leu 
        115                 120                 125             


Pro Glu Leu Ala Ala Leu Cys Arg Arg Lys Leu Lys Arg Ala Gly Lys 
    130                 135                 140                 


Pro Phe Gly Ser Gly Arg Ala Gly Ser Thr Gly Met Gly Arg Pro Pro 
145                 150                 155                 160 


Arg Ser Gln Arg Leu Ser Thr Ala Ser Val Ile Gln Ala Arg Tyr Gln 
                165                 170                 175     


Gly Leu Val Asp Gly Arg Lys Gly Ala His Ala Pro Gln Glu Leu Pro 
            180                 185                 190         


Gln Ala Lys Gly Ser Asp Asp Glu Leu Phe Leu Gly Gly Ser Asn Gln 
        195                 200                 205             


Asp Ser Val Gln Gly Leu Gly Arg Ala Val Cys Pro Ala Gly Gly Glu 
    210                 215                 220                 


Ala Gly Leu Gly Gly Cys Ser Ser Ser Thr Asn Gly Ser Ser Gly Gly 
225                 230                 235                 240 


Cys Glu Gln Glu Leu Gly Leu Asp Leu Ser Lys Lys Ser Pro Pro Leu 
                245                 250                 255     


Pro Pro Ala Thr Pro Gly Pro His Leu Thr Pro Asp Asp Ala Ala Gln 
            260                 265                 270         


Leu Ser Asp Ser Gln His Gly Ser Pro Pro Ala Ala Ser Ala Pro Pro 
        275                 280                 285             


Val Ala Asn Ser Ala Ser Tyr Ser Glu Leu Gly Gly Thr Pro Asp Glu 
    290                 295                 300                 


Pro Met Asp Leu Glu Gly Ala Glu Asp Asn His Leu Ser Leu Leu Glu 
305                 310                 315                 320 


Ala Pro Gly Gly Gln Pro Arg Lys Ser Leu Arg His Ser Thr Arg Lys 
                325                 330                 335     


Lys Glu Trp Gly Lys Lys Glu Pro Val Ala Gly Ser Pro Phe Glu Arg 
            340                 345                 350         


Arg Glu Ala Gly Pro Lys Gly Pro Cys Pro Gly Glu Glu Gly Glu Gly 
        355                 360                 365             


Val Gly Asp Arg Val Pro Asn Gly Ile Leu Ala Ser Gly Ala Gly Pro 
    370                 375                 380                 


Ser Gly Pro Tyr Gly Glu Pro Pro Tyr Pro Cys Lys Glu Glu Glu Glu 
385                 390                 395                 400 


Asn Gly Lys Asp Ala Ser Glu Asp Ser Ala Gln Ser Gly Ser Glu Gly 
                405                 410                 415     


Gly Ser Gly His Ala Ser Ala His Tyr Met Tyr Arg Gln Glu Gly Tyr 
            420                 425                 430         


Glu Thr Val Ser Tyr Gly Asp Asn Leu Tyr Val Cys Ile Pro Cys Ala 
        435                 440                 445             


Lys Gly Phe Pro Ser Ser Glu Gln Leu Asn Ala His Val Glu Thr His 
    450                 455                 460                 


Thr Glu Glu Glu Leu Phe Ile Lys Glu Glu Gly Ala Tyr Glu Thr Gly 
465                 470                 475                 480 


Ser Gly Gly Ala Glu Glu Glu Ala Glu Asp Leu Ser Ala Pro Ser Ala 
                485                 490                 495     


Ala Tyr Thr Ala Glu Pro Arg Pro Phe Lys Cys Ser Val Cys Glu Lys 
            500                 505                 510         


Thr Tyr Lys Asp Pro Ala Thr Leu Arg Gln His Glu Lys Thr His Trp 
        515                 520                 525             


Leu Thr Arg Pro Phe Pro Cys Asn Ile Cys Gly Lys Met Phe Thr Gln 
    530                 535                 540                 


Arg Gly Thr Met Thr Arg His Met Arg Ser His Leu Gly Leu Lys Pro 
545                 550                 555                 560 


Phe Ala Cys Asp Glu Cys Gly Met Arg Phe Thr Arg Gln Tyr Arg Leu 
                565                 570                 575     


Thr Glu His Met Arg Val His Ser Gly Glu Lys Pro Tyr Glu Cys Gln 
            580                 585                 590         


Leu Cys Gly Gly Lys Phe Thr Gln Gln Arg Asn Leu Ile Ser His Leu 
        595                 600                 605             


Arg Met His Thr Ser Pro Ser 
    610                 615 


<210>  4977
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HID1__Homo_sapiens__NP_085133

<400>  4977

Met Gly Ser Thr Asp Ser Lys Leu Asn Phe Arg Lys Ala Val Ile Gln 
1               5                   10                  15      


Leu Thr Thr Lys Thr Gln Pro Val Glu Ala Thr Asp Asp Ala Phe Trp 
            20                  25                  30          


Asp Gln Phe Trp Ala Asp Thr Ala Thr Ser Val Gln Asp Val Phe Ala 
        35                  40                  45              


Leu Val Pro Ala Ala Glu Ile Arg Ala Val Arg Glu Glu Ser Pro Ser 
    50                  55                  60                  


Asn Leu Ala Thr Leu Cys Tyr Lys Ala Val Glu Lys Leu Val Gln Gly 
65                  70                  75                  80  


Ala Glu Ser Gly Cys His Ser Glu Lys Glu Lys Gln Ile Val Leu Asn 
                85                  90                  95      


Cys Ser Arg Leu Leu Thr Arg Val Leu Pro Tyr Ile Phe Glu Asp Pro 
            100                 105                 110         


Asp Trp Arg Gly Phe Phe Trp Ser Thr Val Pro Gly Ala Gly Arg Gly 
        115                 120                 125             


Gly Gln Gly Glu Glu Asp Asp Glu His Ala Arg Pro Leu Ala Glu Ser 
    130                 135                 140                 


Leu Leu Leu Ala Ile Ala Asp Leu Leu Phe Cys Pro Asp Phe Thr Val 
145                 150                 155                 160 


Gln Ser His Arg Arg Ser Thr Val Asp Ser Ala Glu Asp Val His Ser 
                165                 170                 175     


Leu Asp Ser Cys Glu Tyr Ile Trp Glu Ala Gly Val Gly Phe Ala His 
            180                 185                 190         


Ser Pro Gln Pro Asn Tyr Ile His Asp Met Asn Arg Met Glu Leu Leu 
        195                 200                 205             


Lys Leu Leu Leu Thr Cys Phe Ser Glu Ala Met Tyr Leu Pro Pro Ala 
    210                 215                 220                 


Pro Glu Ser Gly Ser Thr Asn Pro Trp Val Gln Phe Phe Cys Ser Thr 
225                 230                 235                 240 


Glu Asn Arg His Ala Leu Pro Leu Phe Thr Ser Leu Leu Asn Thr Val 
                245                 250                 255     


Cys Ala Tyr Asp Pro Val Gly Tyr Gly Ile Pro Tyr Asn His Leu Leu 
            260                 265                 270         


Phe Ser Asp Tyr Arg Glu Pro Leu Val Glu Glu Ala Ala Gln Val Leu 
        275                 280                 285             


Ile Val Thr Leu Asp His Asp Ser Ala Ser Ser Ala Ser Pro Thr Val 
    290                 295                 300                 


Asp Gly Thr Thr Thr Gly Thr Ala Met Asp Asp Ala Asp Pro Pro Gly 
305                 310                 315                 320 


Pro Glu Asn Leu Phe Val Asn Tyr Leu Ser Arg Ile His Arg Glu Glu 
                325                 330                 335     


Asp Phe Gln Phe Ile Leu Lys Gly Ile Ala Arg Leu Leu Ser Asn Pro 
            340                 345                 350         


Leu Leu Gln Thr Tyr Leu Pro Asn Ser Thr Lys Lys Ile Gln Phe His 
        355                 360                 365             


Gln Glu Leu Leu Val Leu Phe Trp Lys Leu Cys Asp Phe Asn Lys Lys 
    370                 375                 380                 


Phe Leu Phe Phe Val Leu Lys Ser Ser Asp Val Leu Asp Ile Leu Val 
385                 390                 395                 400 


Pro Ile Leu Phe Phe Leu Asn Asp Ala Arg Ala Asp Gln Ser Arg Val 
                405                 410                 415     


Gly Leu Met His Ile Gly Val Phe Ile Leu Leu Leu Leu Ser Gly Glu 
            420                 425                 430         


Arg Asn Phe Gly Val Arg Leu Asn Lys Pro Tyr Ser Ile Arg Val Pro 
        435                 440                 445             


Met Asp Ile Pro Val Phe Thr Gly Thr His Ala Asp Leu Leu Ile Val 
    450                 455                 460                 


Val Phe His Lys Ile Ile Thr Ser Gly His Gln Arg Leu Gln Pro Leu 
465                 470                 475                 480 


Phe Asp Cys Leu Leu Thr Ile Val Val Asn Val Ser Pro Tyr Leu Lys 
                485                 490                 495     


Ser Leu Ser Met Val Thr Ala Asn Lys Leu Leu His Leu Leu Glu Ala 
            500                 505                 510         


Phe Ser Thr Thr Trp Phe Leu Phe Ser Ala Ala Gln Asn His His Leu 
        515                 520                 525             


Val Phe Phe Leu Leu Glu Val Phe Asn Asn Ile Ile Gln Tyr Gln Phe 
    530                 535                 540                 


Asp Gly Asn Ser Asn Leu Val Tyr Ala Ile Ile Arg Lys Arg Ser Ile 
545                 550                 555                 560 


Phe His Gln Leu Ala Asn Leu Pro Thr Asp Pro Pro Thr Ile His Lys 
                565                 570                 575     


Ala Leu Gln Arg Arg Arg Arg Thr Pro Glu Pro Leu Ser Arg Thr Gly 
            580                 585                 590         


Ser Gln Glu Gly Thr Ser Met Glu Gly Ser Arg Pro Ala Ala Pro Ala 
        595                 600                 605             


Glu Pro Gly Thr Leu Lys Thr Ser Leu Val Ala Thr Pro Gly Ile Asp 
    610                 615                 620                 


Lys Leu Thr Glu Lys Ser Gln Val Ser Glu Asp Gly Thr Leu Arg Ser 
625                 630                 635                 640 


Leu Glu Pro Glu Pro Gln Gln Ser Leu Glu Asp Gly Ser Pro Ala Lys 
                645                 650                 655     


Gly Glu Pro Ser Gln Ala Trp Arg Glu Gln Arg Arg Pro Ser Thr Ser 
            660                 665                 670         


Ser Ala Ser Gly Gln Trp Ser Pro Thr Pro Glu Trp Val Leu Ser Trp 
        675                 680                 685             


Lys Ser Lys Leu Pro Leu Gln Thr Ile Met Arg Leu Leu Gln Val Leu 
    690                 695                 700                 


Val Pro Gln Val Glu Lys Ile Cys Ile Asp Lys Gly Leu Thr Asp Glu 
705                 710                 715                 720 


Ser Glu Ile Leu Arg Phe Leu Gln His Gly Thr Leu Val Gly Leu Leu 
                725                 730                 735     


Pro Val Pro His Pro Ile Leu Ile Arg Lys Tyr Gln Ala Asn Ser Gly 
            740                 745                 750         


Thr Ala Met Trp Phe Arg Thr Tyr Met Trp Gly Val Ile Tyr Leu Arg 
        755                 760                 765             


Asn Val Asp Pro Pro Val Trp Tyr Asp Thr Asp Val Lys Leu Phe Glu 
    770                 775                 780                 


Ile Gln Arg Val 
785             


<210>  4978
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIF1A__Homo_sapiens__NP_001230013

<400>  4978

Met Ser Ser Gln Cys Arg Ser Leu Glu Asn Lys Phe Val Phe Leu Lys 
1               5                   10                  15      


Glu Gly Leu Gly Asn Ser Lys Pro Glu Glu Leu Glu Glu Ile Arg Ile 
            20                  25                  30          


Glu Asn Gly Arg Ile Ser Ser Glu Arg Arg Lys Glu Lys Ser Arg Asp 
        35                  40                  45              


Ala Ala Arg Ser Arg Arg Ser Lys Glu Ser Glu Val Phe Tyr Glu Leu 
    50                  55                  60                  


Ala His Gln Leu Pro Leu Pro His Asn Val Ser Ser His Leu Asp Lys 
65                  70                  75                  80  


Ala Ser Val Met Arg Leu Thr Ile Ser Tyr Leu Arg Val Arg Lys Leu 
                85                  90                  95      


Leu Asp Ala Gly Asp Leu Asp Ile Glu Asp Asp Met Lys Ala Gln Met 
            100                 105                 110         


Asn Cys Phe Tyr Leu Lys Ala Leu Asp Gly Phe Val Met Val Leu Thr 
        115                 120                 125             


Asp Asp Gly Asp Met Ile Tyr Ile Ser Asp Asn Val Asn Lys Tyr Met 
    130                 135                 140                 


Gly Leu Thr Gln Phe Glu Leu Thr Gly His Ser Val Phe Asp Phe Thr 
145                 150                 155                 160 


His Pro Cys Asp His Glu Glu Met Arg Glu Met Leu Thr His Arg Asn 
                165                 170                 175     


Gly Leu Val Lys Lys Gly Lys Glu Gln Asn Thr Gln Arg Ser Phe Phe 
            180                 185                 190         


Leu Arg Met Lys Cys Thr Leu Thr Ser Arg Gly Arg Thr Met Asn Ile 
        195                 200                 205             


Lys Ser Ala Thr Trp Lys Val Leu His Cys Thr Gly His Ile His Val 
    210                 215                 220                 


Tyr Asp Thr Asn Ser Asn Gln Pro Gln Cys Gly Tyr Lys Lys Pro Pro 
225                 230                 235                 240 


Met Thr Cys Leu Val Leu Ile Cys Glu Pro Ile Pro His Pro Ser Asn 
                245                 250                 255     


Ile Glu Ile Pro Leu Asp Ser Lys Thr Phe Leu Ser Arg His Ser Leu 
            260                 265                 270         


Asp Met Lys Phe Ser Tyr Cys Asp Glu Arg Ile Thr Glu Leu Met Gly 
        275                 280                 285             


Tyr Glu Pro Glu Glu Leu Leu Gly Arg Ser Ile Tyr Glu Tyr Tyr His 
    290                 295                 300                 


Ala Leu Asp Ser Asp His Leu Thr Lys Thr His His Asp Met Phe Thr 
305                 310                 315                 320 


Lys Gly Gln Val Thr Thr Gly Gln Tyr Arg Met Leu Ala Lys Arg Gly 
                325                 330                 335     


Gly Tyr Val Trp Val Glu Thr Gln Ala Thr Val Ile Tyr Asn Thr Lys 
            340                 345                 350         


Asn Ser Gln Pro Gln Cys Ile Val Cys Val Asn Tyr Val Val Ser Gly 
        355                 360                 365             


Ile Ile Gln His Asp Leu Ile Phe Ser Leu Gln Gln Thr Glu Cys Val 
    370                 375                 380                 


Leu Lys Pro Val Glu Ser Ser Asp Met Lys Met Thr Gln Leu Phe Thr 
385                 390                 395                 400 


Lys Val Glu Ser Glu Asp Thr Ser Ser Leu Phe Asp Lys Leu Lys Lys 
                405                 410                 415     


Glu Pro Asp Ala Leu Thr Leu Leu Ala Pro Ala Ala Gly Asp Thr Ile 
            420                 425                 430         


Ile Ser Leu Asp Phe Gly Ser Asn Asp Thr Glu Thr Asp Asp Gln Gln 
        435                 440                 445             


Leu Glu Glu Val Pro Leu Tyr Asn Asp Val Met Leu Pro Ser Pro Asn 
    450                 455                 460                 


Glu Lys Leu Gln Asn Ile Asn Leu Ala Met Ser Pro Leu Pro Thr Ala 
465                 470                 475                 480 


Glu Thr Pro Lys Pro Leu Arg Ser Ser Ala Asp Pro Ala Leu Asn Gln 
                485                 490                 495     


Glu Val Ala Leu Lys Leu Glu Pro Asn Pro Glu Ser Leu Glu Leu Ser 
            500                 505                 510         


Phe Thr Met Pro Gln Ile Gln Asp Gln Thr Pro Ser Pro Ser Asp Gly 
        515                 520                 525             


Ser Thr Arg Gln Ser Ser Pro Glu Pro Asn Ser Pro Ser Glu Tyr Cys 
    530                 535                 540                 


Phe Tyr Val Asp Ser Asp Met Val Asn Glu Phe Lys Leu Glu Leu Val 
545                 550                 555                 560 


Glu Lys Leu Phe Ala Glu Asp Thr Glu Ala Lys Asn Pro Phe Ser Thr 
                565                 570                 575     


Gln Asp Thr Asp Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Pro Met 
            580                 585                 590         


Asp Asp Asp Phe Gln Leu Arg Ser Phe Asp Gln Leu Ser Pro Leu Glu 
        595                 600                 605             


Ser Ser Ser Ala Ser Pro Glu Ser Ala Ser Pro Gln Ser Thr Val Thr 
    610                 615                 620                 


Val Phe Gln Gln Thr Gln Ile Gln Glu Pro Thr Ala Asn Ala Thr Thr 
625                 630                 635                 640 


Thr Thr Ala Thr Thr Asp Glu Leu Lys Thr Val Thr Lys Asp Arg Met 
                645                 650                 655     


Glu Asp Ile Lys Ile Leu Ile Ala Ser Pro Ser Pro Thr His Ile His 
            660                 665                 670         


Lys Glu Thr Thr Ser Ala Thr Ser Ser Pro Tyr Arg Asp Thr Gln Ser 
        675                 680                 685             


Arg Thr Ala Ser Pro Asn Arg Ala Gly Lys Gly Val Ile Glu Gln Thr 
    690                 695                 700                 


Glu Lys Ser His Pro Arg Ser Pro Asn Val Leu Ser Val Ala Leu Ser 
705                 710                 715                 720 


Gln Arg Thr Thr Val Pro Glu Glu Glu Leu Asn Pro Lys Ile Leu Ala 
                725                 730                 735     


Leu Gln Asn Ala Gln Arg Lys Arg Lys Met Glu His Asp Gly Ser Leu 
            740                 745                 750         


Phe Gln Ala Val Gly Ile Gly Thr Leu Leu Gln Gln Pro Asp Asp His 
        755                 760                 765             


Ala Ala Thr Thr Ser Leu Ser Trp Lys Arg Val Lys Gly Cys Lys Ser 
    770                 775                 780                 


Ser Glu Gln Asn Gly Met Glu Gln Lys Thr Ile Ile Leu Ile Pro Ser 
785                 790                 795                 800 


Asp Leu Ala Cys Arg Leu Leu Gly Gln Ser Met Asp Glu Ser Gly Leu 
                805                 810                 815     


Pro Gln Leu Thr Ser Tyr Asp Cys Glu Val Asn Ala Pro Ile Gln Gly 
            820                 825                 830         


Ser Arg Asn Leu Leu Gln Gly Glu Glu Leu Leu Arg Ala Leu Asp Gln 
        835                 840                 845             


Val Asn 
    850 


<210>  4979
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIF1AN__Homo_sapiens__NP_060372

<400>  4979

Met Ala Ala Thr Ala Ala Glu Ala Val Ala Ser Gly Ser Gly Glu Pro 
1               5                   10                  15      


Arg Glu Glu Ala Gly Ala Leu Gly Pro Ala Trp Asp Glu Ser Gln Leu 
            20                  25                  30          


Arg Ser Tyr Ser Phe Pro Thr Arg Pro Ile Pro Arg Leu Ser Gln Ser 
        35                  40                  45              


Asp Pro Arg Ala Glu Glu Leu Ile Glu Asn Glu Glu Pro Val Val Leu 
    50                  55                  60                  


Thr Asp Thr Asn Leu Val Tyr Pro Ala Leu Lys Trp Asp Leu Glu Tyr 
65                  70                  75                  80  


Leu Gln Glu Asn Ile Gly Asn Gly Asp Phe Ser Val Tyr Ser Ala Ser 
                85                  90                  95      


Thr His Lys Phe Leu Tyr Tyr Asp Glu Lys Lys Met Ala Asn Phe Gln 
            100                 105                 110         


Asn Phe Lys Pro Arg Ser Asn Arg Glu Glu Met Lys Phe His Glu Phe 
        115                 120                 125             


Val Glu Lys Leu Gln Asp Ile Gln Gln Arg Gly Gly Glu Glu Arg Leu 
    130                 135                 140                 


Tyr Leu Gln Gln Thr Leu Asn Asp Thr Val Gly Arg Lys Ile Val Met 
145                 150                 155                 160 


Asp Phe Leu Gly Phe Asn Trp Asn Trp Ile Asn Lys Gln Gln Gly Lys 
                165                 170                 175     


Arg Gly Trp Gly Gln Leu Thr Ser Asn Leu Leu Leu Ile Gly Met Glu 
            180                 185                 190         


Gly Asn Val Thr Pro Ala His Tyr Asp Glu Gln Gln Asn Phe Phe Ala 
        195                 200                 205             


Gln Ile Lys Gly Tyr Lys Arg Cys Ile Leu Phe Pro Pro Asp Gln Phe 
    210                 215                 220                 


Glu Cys Leu Tyr Pro Tyr Pro Val His His Pro Cys Asp Arg Gln Ser 
225                 230                 235                 240 


Gln Val Asp Phe Asp Asn Pro Asp Tyr Glu Arg Phe Pro Asn Phe Gln 
                245                 250                 255     


Asn Val Val Gly Tyr Glu Thr Val Val Gly Pro Gly Asp Val Leu Tyr 
            260                 265                 270         


Ile Pro Met Tyr Trp Trp His His Ile Glu Ser Leu Leu Asn Gly Gly 
        275                 280                 285             


Ile Thr Ile Thr Val Asn Phe Trp Tyr Lys Gly Ala Pro Thr Pro Lys 
    290                 295                 300                 


Arg Ile Glu Tyr Pro Leu Lys Ala His Gln Lys Val Ala Ile Met Arg 
305                 310                 315                 320 


Asn Ile Glu Lys Met Leu Gly Glu Ala Leu Gly Asn Pro Gln Glu Val 
                325                 330                 335     


Gly Pro Leu Leu Asn Thr Met Ile Lys Gly Arg Tyr Asn 
            340                 345                 


<210>  4980
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIF3A__Homo_sapiens__NP_690007

<400>  4980

Met Asp Trp Gln Asp His Arg Ser Thr Thr Glu Leu Arg Lys Glu Lys 
1               5                   10                  15      


Ser Arg Asp Ala Ala Arg Ser Arg Arg Ser Gln Glu Thr Glu Val Leu 
            20                  25                  30          


Tyr Gln Leu Ala His Thr Leu Pro Phe Ala Arg Gly Val Ser Ala His 
        35                  40                  45              


Leu Asp Lys Ala Ser Ile Met Arg Leu Thr Ile Ser Tyr Leu Arg Met 
    50                  55                  60                  


His Arg Leu Cys Ala Ala Gly Glu Trp Asn Gln Val Gly Ala Gly Gly 
65                  70                  75                  80  


Glu Pro Leu Asp Ala Cys Tyr Leu Lys Ala Leu Glu Gly Phe Val Met 
                85                  90                  95      


Val Leu Thr Ala Glu Gly Asp Met Ala Tyr Leu Ser Glu Asn Val Ser 
            100                 105                 110         


Lys His Leu Gly Leu Ser Gln Leu Glu Leu Ile Gly His Ser Ile Phe 
        115                 120                 125             


Asp Phe Ile His Pro Cys Asp Gln Glu Glu Leu Gln Asp Ala Leu Thr 
    130                 135                 140                 


Pro Gln Gln Thr Leu Ser Arg Arg Lys Val Glu Ala Pro Thr Glu Arg 
145                 150                 155                 160 


Cys Phe Ser Leu Arg Met Lys Ser Thr Leu Thr Ser Arg Gly Arg Thr 
                165                 170                 175     


Leu Asn Leu Lys Ala Ala Thr Trp Lys Val Leu Asn Cys Ser Gly His 
            180                 185                 190         


Met Arg Ala Tyr Lys Pro Pro Ala Gln Thr Ser Pro Ala Gly Ser Pro 
        195                 200                 205             


Asp Ser Glu Pro Pro Leu Gln Cys Leu Val Leu Ile Cys Glu Ala Ile 
    210                 215                 220                 


Pro His Pro Gly Ser Leu Glu Pro Pro Leu Gly Arg Gly Ala Phe Leu 
225                 230                 235                 240 


Ser Arg His Ser Leu Asp Met Lys Phe Thr Tyr Cys Asp Asp Arg Ile 
                245                 250                 255     


Ala Glu Val Ala Gly Tyr Ser Pro Asp Asp Leu Ile Gly Cys Ser Ala 
            260                 265                 270         


Tyr Glu Tyr Ile His Ala Leu Asp Ser Asp Ala Val Ser Lys Ser Ile 
        275                 280                 285             


His Thr Leu Leu Ser Lys Gly Gln Ala Val Thr Gly Gln Tyr Arg Phe 
    290                 295                 300                 


Leu Ala Arg Ser Gly Gly Tyr Leu Trp Thr Gln Thr Gln Ala Thr Val 
305                 310                 315                 320 


Val Ser Gly Gly Arg Gly Pro Gln Ser Glu Ser Ile Val Cys Val His 
                325                 330                 335     


Phe Leu Ile Ser Gln Val Glu Glu Thr Gly Val Val Leu Ser Leu Glu 
            340                 345                 350         


Gln Thr Glu Gln His Ser Arg Arg Pro Ile Gln Arg Gly Ala Pro Ser 
        355                 360                 365             


Gln Lys Asp Thr Pro Asn Pro Gly Asp Ser Leu Asp Thr Pro Gly Pro 
    370                 375                 380                 


Arg Ile Leu Ala Phe Leu His Pro Pro Ser Leu Ser Glu Ala Ala Leu 
385                 390                 395                 400 


Ala Ala Asp Pro Arg Arg Phe Cys Ser Pro Asp Leu Arg Arg Leu Leu 
                405                 410                 415     


Gly Pro Ile Leu Asp Gly Ala Ser Val Ala Ala Thr Pro Ser Thr Pro 
            420                 425                 430         


Leu Ala Thr Arg His Pro Gln Ser Pro Leu Ser Ala Asp Leu Pro Asp 
        435                 440                 445             


Glu Leu Pro Val Gly Thr Glu Asn Val His Arg Leu Phe Thr Ser Gly 
    450                 455                 460                 


Lys Asp Thr Glu Ala Val Glu Thr Asp Leu Asp Ile Ala Gln Asp Ala 
465                 470                 475                 480 


Asp Ala Leu Asp Leu Glu Met Leu Ala Pro Tyr Ile Ser Met Asp Asp 
                485                 490                 495     


Asp Phe Gln Leu Asn Ala Ser Glu Gln Leu Pro Arg Ala Tyr His Arg 
            500                 505                 510         


Pro Leu Gly Ala Val Pro Arg Pro Arg Ala Arg Ser Phe His Gly Leu 
        515                 520                 525             


Ser Pro Pro Ala Leu Glu Pro Ser Leu Leu Pro Arg Trp Gly Ser Asp 
    530                 535                 540                 


Pro Arg Leu Ser Cys Ser Ser Pro Ser Arg Gly Asp Pro Ser Ala Ser 
545                 550                 555                 560 


Ser Pro Met Ala Gly Ala Arg Lys Arg Thr Leu Ala Gln Ser Ser Glu 
                565                 570                 575     


Asp Glu Asp Glu Gly Val Glu Leu Leu Gly Val Arg Pro Pro Lys Arg 
            580                 585                 590         


Ser Pro Ser Pro Glu His Glu Asn Phe Leu Leu Phe Pro Leu Ser Leu 
        595                 600                 605             


Ser Phe Leu Leu Thr Gly Gly Pro Ala Pro Gly Ser Leu Gln Asp Pro 
    610                 615                 620                 


Ser Thr Pro Leu Leu Asn Leu Asn Glu Pro Leu Gly Leu Gly Pro Ser 
625                 630                 635                 640 


Leu Leu Ser Pro Tyr Ser Asp Glu Asp Thr Thr Gln Pro Gly Gly Pro 
                645                 650                 655     


Phe Gln Pro Arg Ala Gly Ser Ala Gln Ala Asp 
            660                 665         


<210>  4981
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIGD1A__Homo_sapiens__NP_001093138

<400>  4981

Met Glu Gln Lys Leu Val Glu Glu Ile Leu Gln Ala Ile Thr Met Ser 
1               5                   10                  15      


Thr Asp Thr Gly Val Ser Leu Pro Ser Tyr Glu Glu Asp Gln Gly Ser 
            20                  25                  30          


Lys Leu Ile Arg Lys Ala Lys Glu Ala Pro Phe Val Pro Val Gly Ile 
        35                  40                  45              


Ala Gly Phe Ala Ala Ile Val Ala Tyr Gly Leu Tyr Lys Leu Lys Ser 
    50                  55                  60                  


Arg Gly Asn Thr Lys Met Ser Ile His Leu Ile His Met Arg Val Ala 
65                  70                  75                  80  


Ala Gln Gly Phe Val Val Gly Ala Met Thr Val Gly Met Gly Tyr Ser 
                85                  90                  95      


Met Tyr Arg Glu Phe Trp Ala Lys Pro Lys Pro 
            100                 105         


<210>  4982
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIGD1C__Homo_sapiens__NP_001103089

<400>  4982

Met Ser Ser Asp Asn Gln Trp Ser Ala Asp Glu Asp Glu Gly Gln Leu 
1               5                   10                  15      


Ser Arg Leu Ile Arg Lys Ser Arg Asp Ser Pro Phe Val Pro Ile Gly 
            20                  25                  30          


Ile Ala Gly Phe Val Thr Val Val Ser Cys Gly Leu Tyr Lys Leu Lys 
        35                  40                  45              


Tyr Arg Arg Asp Gln Lys Met Ser Ile His Leu Ile His Met Arg Val 
    50                  55                  60                  


Ala Ala Gln Gly Phe Val Val Gly Ala Val Thr Leu Gly Val Leu Tyr 
65                  70                  75                  80  


Ser Met Tyr Lys Asp Tyr Ile Arg Pro Arg Phe Phe Ser Glu Ser Lys 
                85                  90                  95      


Lys 
    


<210>  4983
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIGD2A__Homo_sapiens__NP_620175

<400>  4983

Met Ala Thr Pro Gly Pro Val Ile Pro Glu Val Pro Phe Glu Pro Ser 
1               5                   10                  15      


Lys Pro Pro Val Ile Glu Gly Leu Ser Pro Thr Val Tyr Arg Asn Pro 
            20                  25                  30          


Glu Ser Phe Lys Glu Lys Phe Val Arg Lys Thr Arg Glu Asn Pro Val 
        35                  40                  45              


Val Pro Ile Gly Cys Leu Ala Thr Ala Ala Ala Leu Thr Tyr Gly Leu 
    50                  55                  60                  


Tyr Ser Phe His Arg Gly Asn Ser Gln Arg Ser Gln Leu Met Met Arg 
65                  70                  75                  80  


Thr Arg Ile Ala Ala Gln Gly Phe Thr Val Ala Ala Ile Leu Leu Gly 
                85                  90                  95      


Leu Ala Val Thr Ala Met Lys Ser Arg Pro 
            100                 105     


<210>  4984
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HILPDA__Homo_sapiens__NP_001092256

<400>  4984

Met Lys His Val Leu Asn Leu Tyr Leu Leu Gly Val Val Leu Thr Leu 
1               5                   10                  15      


Leu Ser Ile Phe Val Arg Val Met Glu Ser Leu Glu Gly Leu Leu Glu 
            20                  25                  30          


Ser Pro Ser Pro Gly Thr Ser Trp Thr Thr Arg Ser Gln Leu Ala Asn 
        35                  40                  45              


Thr Glu Pro Thr Lys Gly Leu Pro Asp His Pro Ser Arg Ser Met 
    50                  55                  60              


<210>  4985
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HINFP__Homo_sapiens__NP_001230188

<400>  4985

Met Pro Pro Pro Gly Lys Val Pro Arg Lys Glu Asn Leu Trp Leu Gln 
1               5                   10                  15      


Cys Glu Trp Gly Ser Cys Ser Phe Val Cys Ser Thr Met Glu Lys Phe 
            20                  25                  30          


Phe Glu His Val Thr Gln His Leu Gln Gln His Leu His Gly Ser Gly 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Pro Leu Glu Glu Glu Phe 
    50                  55                  60                  


Ser Cys Leu Trp Gln Glu Cys Gly Phe Cys Ser Leu Asp Ser Ser Ala 
65                  70                  75                  80  


Asp Leu Ile Arg His Val Tyr Phe His Cys Tyr His Thr Lys Leu Lys 
                85                  90                  95      


Gln Trp Gly Leu Gln Ala Leu Gln Ser Gln Ala Asp Leu Gly Pro Cys 
            100                 105                 110         


Ile Leu Asp Phe Gln Ser Arg Asn Val Ile Pro Asp Ile Pro Asp His 
        115                 120                 125             


Phe Leu Cys Leu Trp Glu His Cys Glu Asn Ser Phe Asp Asn Pro Glu 
    130                 135                 140                 


Trp Phe Tyr Arg His Val Glu Ala His Ser Leu Cys Cys Glu Tyr Glu 
145                 150                 155                 160 


Ala Val Gly Lys Asp Asn Pro Val Val Leu Cys Gly Trp Lys Gly Cys 
                165                 170                 175     


Thr Cys Thr Phe Lys Asp Arg Ser Lys Leu Arg Glu His Leu Arg Ser 
            180                 185                 190         


His Thr Gln Glu Lys Val Val Ala Cys Pro Thr Cys Gly Gly Met Phe 
        195                 200                 205             


Ala Asn Asn Thr Lys Phe Leu Asp His Ile Arg Arg Gln Thr Ser Leu 
    210                 215                 220                 


Asp Gln Gln His Phe Gln Cys Ser His Cys Ser Lys Arg Phe Ala Thr 
225                 230                 235                 240 


Glu Arg Leu Leu Arg Asp His Met Arg Asn His Val Asn His Tyr Lys 
                245                 250                 255     


Cys Pro Leu Cys Asp Met Thr Cys Pro Leu Pro Ser Ser Leu Arg Asn 
            260                 265                 270         


His Met Arg Phe Arg His Ser Glu Asp Arg Pro Phe Lys Cys Asp Cys 
        275                 280                 285             


Cys Asp Tyr Ser Cys Lys Asn Leu Ile Asp Leu Gln Lys His Leu Asp 
    290                 295                 300                 


Thr His Ser Glu Glu Pro Ala Tyr Arg Cys Asp Phe Glu Asn Cys Thr 
305                 310                 315                 320 


Phe Ser Ala Arg Ser Leu Cys Ser Ile Lys Ser His Tyr Arg Lys Val 
                325                 330                 335     


His Glu Gly Asp Ser Glu Pro Arg Tyr Lys Cys His Val Cys Asp Lys 
            340                 345                 350         


Cys Phe Thr Arg Gly Asn Asn Leu Thr Val His Leu Arg Lys Lys His 
        355                 360                 365             


Gln Phe Lys Trp Pro Ser Gly His Pro Arg Phe Arg Leu Gly His Phe 
    370                 375                 380                 


Cys Ile Pro Leu Pro Gly Phe Ala Ala Leu Tyr Ala Pro Thr Ser Pro 
385                 390                 395                 400 


Gly Thr Arg Asn Met Lys Met Ala Ile Cys Gly Cys Ser Trp Phe Ala 
                405                 410                 415     


Thr Arg Val 
            


<210>  4986
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HINT1__Homo_sapiens__NP_005331

<400>  4986

Met Ala Asp Glu Ile Ala Lys Ala Gln Val Ala Arg Pro Gly Gly Asp 
1               5                   10                  15      


Thr Ile Phe Gly Lys Ile Ile Arg Lys Glu Ile Pro Ala Lys Ile Ile 
            20                  25                  30          


Phe Glu Asp Asp Arg Cys Leu Ala Phe His Asp Ile Ser Pro Gln Ala 
        35                  40                  45              


Pro Thr His Phe Leu Val Ile Pro Lys Lys His Ile Ser Gln Ile Ser 
    50                  55                  60                  


Val Ala Glu Asp Asp Asp Glu Ser Leu Leu Gly His Leu Met Ile Val 
65                  70                  75                  80  


Gly Lys Lys Cys Ala Ala Asp Leu Gly Leu Asn Lys Gly Tyr Arg Met 
                85                  90                  95      


Val Val Asn Glu Gly Ser Asp Gly Gly Gln Ser Val Tyr His Val His 
            100                 105                 110         


Leu His Val Leu Gly Gly Arg Gln Met His Trp Pro Pro Gly 
        115                 120                 125     


<210>  4987
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HINT2__Homo_sapiens__NP_115982

<400>  4987

Met Ala Ala Ala Val Val Leu Ala Ala Gly Leu Arg Ala Ala Arg Arg 
1               5                   10                  15      


Ala Val Ala Ala Thr Gly Val Arg Gly Gly Gln Val Arg Gly Ala Ala 
            20                  25                  30          


Gly Val Thr Asp Gly Asn Glu Val Ala Lys Ala Gln Gln Ala Thr Pro 
        35                  40                  45              


Gly Gly Ala Ala Pro Thr Ile Phe Ser Arg Ile Leu Asp Lys Ser Leu 
    50                  55                  60                  


Pro Ala Asp Ile Leu Tyr Glu Asp Gln Gln Cys Leu Val Phe Arg Asp 
65                  70                  75                  80  


Val Ala Pro Gln Ala Pro Val His Phe Leu Val Ile Pro Lys Lys Pro 
                85                  90                  95      


Ile Pro Arg Ile Ser Gln Ala Glu Glu Glu Asp Gln Gln Leu Leu Gly 
            100                 105                 110         


His Leu Leu Leu Val Ala Lys Gln Thr Ala Lys Ala Glu Gly Leu Gly 
        115                 120                 125             


Asp Gly Tyr Arg Leu Val Ile Asn Asp Gly Lys Leu Gly Ala Gln Ser 
    130                 135                 140                 


Val Tyr His Leu His Ile His Val Leu Gly Gly Arg Gln Leu Gln Trp 
145                 150                 155                 160 


Pro Pro Gly 
            


<210>  4988
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP1__Homo_sapiens__NP_001230127

<400>  4988

Met Asp Arg Met Ala Ser Ser Met Lys Gln Val Pro Asn Pro Leu Pro 
1               5                   10                  15      


Lys Val Leu Ser Arg Arg Gly Val Gly Ala Gly Leu Glu Ala Ala Glu 
            20                  25                  30          


Arg Glu Ser Phe Glu Arg Thr Gln Thr Val Ser Ile Asn Lys Ala Ile 
        35                  40                  45              


Asn Thr Gln Glu Val Ala Val Lys Glu Lys His Ala Arg Thr Cys Ile 
    50                  55                  60                  


Leu Gly Thr His His Glu Lys Gly Ala Gln Thr Phe Trp Ser Val Val 
65                  70                  75                  80  


Asn Arg Leu Pro Leu Ser Ser Asn Ala Val Leu Cys Trp Lys Phe Cys 
                85                  90                  95      


His Val Phe His Lys Leu Leu Arg Asp Gly His Pro Asn Val Leu Lys 
            100                 105                 110         


Asp Ser Leu Arg Tyr Arg Asn Glu Leu Ser Asp Met Ser Arg Met Trp 
        115                 120                 125             


Gly His Leu Ser Glu Gly Tyr Gly Gln Leu Cys Ser Ile Tyr Leu Lys 
    130                 135                 140                 


Leu Leu Arg Thr Lys Met Glu Tyr His Thr Lys Asn Pro Arg Phe Pro 
145                 150                 155                 160 


Gly Asn Leu Gln Met Ser Asp Arg Gln Leu Asp Glu Ala Gly Glu Ser 
                165                 170                 175     


Asp Val Asn Asn Phe Phe Gln Leu Thr Val Glu Met Phe Asp Tyr Leu 
            180                 185                 190         


Glu Cys Glu Leu Asn Leu Phe Gln Thr Val Phe Asn Ser Leu Asp Met 
        195                 200                 205             


Ser Arg Ser Val Ser Val Thr Ala Ala Gly Gln Cys Arg Leu Ala Pro 
    210                 215                 220                 


Leu Ile Gln Val Ile Leu Asp Cys Ser His Leu Tyr Asp Tyr Thr Val 
225                 230                 235                 240 


Lys Leu Leu Phe Lys Leu His Ser Cys Leu Pro Ala Asp Thr Leu Gln 
                245                 250                 255     


Gly His Arg Asp Arg Phe Met Glu Gln Phe Thr Lys Leu Lys Asp Leu 
            260                 265                 270         


Phe Tyr Arg Ser Ser Asn Leu Gln Tyr Phe Lys Arg Leu Ile Gln Ile 
        275                 280                 285             


Pro Gln Leu Pro Glu Asn Pro Pro Asn Phe Leu Arg Ala Ser Ala Leu 
    290                 295                 300                 


Ser Glu His Ile Ser Pro Val Val Val Ile Pro Ala Glu Ala Ser Ser 
305                 310                 315                 320 


Pro Asp Ser Glu Pro Val Leu Glu Lys Asp Asp Leu Met Asp Met Asp 
                325                 330                 335     


Ala Ser Gln Gln Asn Leu Phe Asp Asn Lys Phe Asp Asp Ile Phe Gly 
            340                 345                 350         


Ser Ser Phe Ser Ser Asp Pro Phe Asn Phe Asn Ser Gln Asn Gly Val 
        355                 360                 365             


Asn Lys Asp Glu Lys Asp His Leu Ile Glu Arg Leu Tyr Arg Glu Ile 
    370                 375                 380                 


Ser Gly Leu Lys Ala Gln Leu Glu Asn Met Lys Thr Glu Ser Gln Arg 
385                 390                 395                 400 


Val Val Leu Gln Leu Lys Gly His Val Ser Glu Leu Glu Ala Asp Leu 
                405                 410                 415     


Ala Glu Gln Gln His Leu Arg Gln Gln Ala Ala Asp Asp Cys Glu Phe 
            420                 425                 430         


Leu Arg Ala Glu Leu Asp Glu Leu Arg Arg Gln Arg Glu Asp Thr Glu 
        435                 440                 445             


Lys Ala Gln Arg Ser Leu Ser Glu Ile Glu Arg Lys Ala Gln Ala Asn 
    450                 455                 460                 


Glu Gln Arg Tyr Ser Lys Leu Lys Glu Lys Tyr Ser Glu Leu Val Gln 
465                 470                 475                 480 


Asn His Ala Asp Leu Leu Arg Lys Asn Ala Glu Val Thr Lys Gln Val 
                485                 490                 495     


Ser Met Ala Arg Gln Ala Gln Val Asp Leu Glu Arg Glu Lys Lys Glu 
            500                 505                 510         


Leu Glu Asp Ser Leu Glu Arg Ile Ser Asp Gln Gly Gln Arg Lys Thr 
        515                 520                 525             


Gln Glu Gln Leu Glu Val Leu Glu Ser Leu Lys Gln Glu Leu Ala Thr 
    530                 535                 540                 


Ser Gln Arg Glu Leu Gln Val Leu Gln Gly Ser Leu Glu Thr Ser Ala 
545                 550                 555                 560 


Gln Ser Glu Ala Asn Trp Ala Ala Glu Phe Ala Glu Leu Glu Lys Glu 
                565                 570                 575     


Arg Asp Ser Leu Val Ser Gly Ala Ala His Arg Glu Glu Glu Leu Ser 
            580                 585                 590         


Ala Leu Arg Lys Glu Leu Gln Asp Thr Gln Leu Lys Leu Ala Ser Thr 
        595                 600                 605             


Glu Glu Ser Met Cys Gln Leu Ala Lys Asp Gln Arg Lys Met Leu Leu 
    610                 615                 620                 


Val Gly Ser Arg Lys Ala Ala Glu Gln Val Ile Gln Asp Ala Leu Asn 
625                 630                 635                 640 


Gln Leu Glu Glu Pro Pro Leu Ile Ser Cys Ala Gly Ser Ala Asp His 
                645                 650                 655     


Leu Leu Ser Thr Val Thr Ser Ile Ser Ser Cys Ile Glu Gln Leu Glu 
            660                 665                 670         


Lys Ser Trp Ser Gln Tyr Leu Ala Cys Pro Glu Asp Ile Ser Gly Leu 
        675                 680                 685             


Leu His Ser Ile Thr Leu Leu Ala His Leu Thr Ser Asp Ala Ile Ala 
    690                 695                 700                 


His Gly Ala Thr Thr Cys Leu Arg Ala Pro Pro Glu Pro Ala Asp Ser 
705                 710                 715                 720 


Leu Thr Glu Ala Cys Lys Gln Tyr Gly Arg Glu Thr Leu Ala Tyr Leu 
                725                 730                 735     


Ala Ser Leu Glu Glu Glu Gly Ser Leu Glu Asn Ala Asp Ser Thr Ala 
            740                 745                 750         


Met Arg Asn Cys Leu Ser Lys Ile Lys Ala Ile Gly Glu Glu Leu Leu 
        755                 760                 765             


Pro Arg Gly Leu Asp Ile Lys Gln Glu Glu Leu Gly Asp Leu Val Asp 
    770                 775                 780                 


Lys Glu Met Ala Ala Thr Ser Ala Ala Ile Glu Thr Ala Thr Ala Arg 
785                 790                 795                 800 


Ile Glu Gly Thr Ala Ser Pro Lys Glu Phe Tyr Ala Lys Asn Ser Arg 
                805                 810                 815     


Trp Thr Glu Gly Leu Ile Ser Ala Ser Lys Ala Val Gly Trp Gly Ala 
            820                 825                 830         


Thr Val Met Val Asp Ala Ala Asp Leu Val Val Gln Gly Arg Gly Lys 
        835                 840                 845             


Phe Glu Glu Leu Met Val Cys Ser His Glu Ile Ala Ala Ser Thr Ala 
    850                 855                 860                 


Gln Leu Val Ala Ala Ser Lys Val Lys Ala Asp Lys Asp Ser Pro Asn 
865                 870                 875                 880 


Leu Ala Gln Leu Gln Gln Ala Ser Arg Gly Val Asn Gln Ala Thr Ala 
                885                 890                 895     


Gly Val Val Ala Ser Thr Ile Ser Gly Lys Ser Gln Ile Glu Glu Thr 
            900                 905                 910         


Asp Asn Met Asp Phe Ser Ser Met Thr Leu Thr Gln Ile Lys Arg Gln 
        915                 920                 925             


Glu Met Asp Ser Gln Val Arg Val Leu Glu Leu Glu Asn Glu Leu Gln 
    930                 935                 940                 


Lys Glu Arg Gln Lys Leu Gly Glu Leu Arg Lys Lys His Tyr Glu Leu 
945                 950                 955                 960 


Ala Gly Val Ala Glu Gly Trp Glu Glu Gly Thr Glu Ala Ser Pro Pro 
                965                 970                 975     


Thr Leu Gln Glu Val Val Thr Glu Lys Glu 
            980                 985     


<210>  4989
<211>  1068
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIP1R__Homo_sapiens__NP_003950

<400>  4989

Met Asn Ser Ile Lys Asn Val Pro Ala Arg Val Leu Ser Arg Arg Pro 
1               5                   10                  15      


Gly His Ser Leu Glu Ala Glu Arg Glu Gln Phe Asp Lys Thr Gln Ala 
            20                  25                  30          


Ile Ser Ile Ser Lys Ala Ile Asn Thr Gln Glu Ala Pro Val Lys Glu 
        35                  40                  45              


Lys His Ala Arg Arg Ile Ile Leu Gly Thr His His Glu Lys Gly Ala 
    50                  55                  60                  


Phe Thr Phe Trp Ser Tyr Ala Ile Gly Leu Pro Leu Pro Ser Ser Ser 
65                  70                  75                  80  


Ile Leu Ser Trp Lys Phe Cys His Val Leu His Lys Val Leu Arg Asp 
                85                  90                  95      


Gly His Pro Asn Val Leu His Asp Cys Gln Arg Tyr Arg Ser Asn Ile 
            100                 105                 110         


Arg Glu Ile Gly Asp Leu Trp Gly His Leu His Asp Arg Tyr Gly Gln 
        115                 120                 125             


Leu Val Asn Val Tyr Thr Lys Leu Leu Leu Thr Lys Ile Ser Phe His 
    130                 135                 140                 


Leu Lys His Pro Gln Phe Pro Ala Gly Leu Glu Val Thr Asp Glu Val 
145                 150                 155                 160 


Leu Glu Lys Ala Ala Gly Thr Asp Val Asn Asn Ile Phe Gln Leu Thr 
                165                 170                 175     


Val Glu Met Phe Asp Tyr Met Asp Cys Glu Leu Lys Leu Ser Glu Ser 
            180                 185                 190         


Val Phe Arg Gln Leu Asn Thr Ala Ile Ala Val Ser Gln Met Ser Ser 
        195                 200                 205             


Gly Gln Cys Arg Leu Ala Pro Leu Ile Gln Val Ile Gln Asp Cys Ser 
    210                 215                 220                 


His Leu Tyr His Tyr Thr Val Lys Leu Leu Phe Lys Leu His Ser Cys 
225                 230                 235                 240 


Leu Pro Ala Asp Thr Leu Gln Gly His Arg Asp Arg Phe His Glu Gln 
                245                 250                 255     


Phe His Ser Leu Arg Asn Phe Phe Arg Arg Ala Ser Asp Met Leu Tyr 
            260                 265                 270         


Phe Lys Arg Leu Ile Gln Ile Pro Arg Leu Pro Glu Gly Pro Pro Asn 
        275                 280                 285             


Phe Leu Arg Ala Ser Ala Leu Ala Glu His Ile Lys Pro Val Val Val 
    290                 295                 300                 


Ile Pro Glu Glu Ala Pro Glu Asp Glu Glu Pro Glu Asn Leu Ile Glu 
305                 310                 315                 320 


Ile Ser Thr Gly Pro Pro Ala Gly Glu Pro Val Val Val Ala Asp Leu 
                325                 330                 335     


Phe Asp Gln Thr Phe Gly Pro Pro Asn Gly Ser Val Lys Asp Asp Arg 
            340                 345                 350         


Asp Leu Gln Ile Glu Ser Leu Lys Arg Glu Val Glu Met Leu Arg Ser 
        355                 360                 365             


Glu Leu Glu Lys Ile Lys Leu Glu Ala Gln Arg Tyr Ile Ala Gln Leu 
    370                 375                 380                 


Lys Ser Gln Val Asn Ala Leu Glu Gly Glu Leu Glu Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Lys Gln Lys Ala Leu Val Asp Asn Glu Gln Leu Arg His Glu Leu 
                405                 410                 415     


Ala Gln Leu Arg Ala Ala Gln Leu Glu Gly Glu Arg Ser Gln Gly Leu 
            420                 425                 430         


Arg Glu Glu Ala Glu Arg Lys Ala Ser Ala Thr Glu Ala Arg Tyr Asn 
        435                 440                 445             


Lys Leu Lys Glu Lys His Ser Glu Leu Val His Val His Ala Glu Leu 
    450                 455                 460                 


Leu Arg Lys Asn Ala Asp Thr Ala Lys Gln Leu Thr Val Thr Gln Gln 
465                 470                 475                 480 


Ser Gln Glu Glu Val Ala Arg Val Lys Glu Gln Leu Ala Phe Gln Val 
                485                 490                 495     


Glu Gln Val Lys Arg Glu Ser Glu Leu Lys Leu Glu Glu Lys Ser Asp 
            500                 505                 510         


Gln Leu Glu Lys Leu Lys Arg Glu Leu Glu Ala Lys Ala Gly Glu Leu 
        515                 520                 525             


Ala Arg Ala Gln Glu Ala Leu Ser His Thr Glu Gln Ser Lys Ser Glu 
    530                 535                 540                 


Leu Ser Ser Arg Leu Asp Thr Leu Ser Ala Glu Lys Asp Ala Leu Ser 
545                 550                 555                 560 


Gly Ala Val Arg Gln Arg Glu Ala Asp Leu Leu Ala Ala Gln Ser Leu 
                565                 570                 575     


Val Arg Glu Thr Glu Ala Ala Leu Ser Arg Glu Gln Gln Arg Ser Ser 
            580                 585                 590         


Gln Glu Gln Gly Glu Leu Gln Gly Arg Leu Ala Glu Arg Glu Ser Gln 
        595                 600                 605             


Glu Gln Gly Leu Arg Gln Arg Leu Leu Asp Glu Gln Phe Ala Val Leu 
    610                 615                 620                 


Arg Gly Ala Ala Ala Glu Ala Ala Gly Ile Leu Gln Asp Ala Val Ser 
625                 630                 635                 640 


Lys Leu Asp Asp Pro Leu His Leu Arg Cys Thr Ser Ser Pro Asp Tyr 
                645                 650                 655     


Leu Val Ser Arg Ala Gln Glu Ala Leu Asp Ala Val Ser Thr Leu Glu 
            660                 665                 670         


Glu Gly His Ala Gln Tyr Leu Thr Ser Leu Ala Asp Ala Ser Ala Leu 
        675                 680                 685             


Val Ala Ala Leu Thr Arg Phe Ser His Leu Ala Ala Asp Thr Ile Ile 
    690                 695                 700                 


Asn Gly Gly Ala Thr Ser His Leu Ala Pro Thr Asp Pro Ala Asp Arg 
705                 710                 715                 720 


Leu Ile Asp Thr Cys Arg Glu Cys Gly Ala Arg Ala Leu Glu Leu Met 
                725                 730                 735     


Gly Gln Leu Gln Asp Gln Gln Ala Leu Arg His Met Gln Ala Ser Leu 
            740                 745                 750         


Val Arg Thr Pro Leu Gln Gly Ile Leu Gln Leu Gly Gln Glu Leu Lys 
        755                 760                 765             


Pro Lys Ser Leu Asp Val Arg Gln Glu Glu Leu Gly Ala Val Val Asp 
    770                 775                 780                 


Lys Glu Met Ala Ala Thr Ser Ala Ala Ile Glu Asp Ala Val Arg Arg 
785                 790                 795                 800 


Ile Glu Asp Met Met Asn Gln Ala Arg His Ala Ser Ser Gly Val Lys 
                805                 810                 815     


Leu Glu Val Asn Glu Arg Ile Leu Asn Ser Cys Thr Asp Leu Met Lys 
            820                 825                 830         


Ala Ile Arg Leu Leu Val Thr Thr Ser Thr Ser Leu Gln Lys Glu Ile 
        835                 840                 845             


Val Glu Ser Gly Arg Gly Ala Ala Thr Gln Gln Glu Phe Tyr Ala Lys 
    850                 855                 860                 


Asn Ser Arg Trp Thr Glu Gly Leu Ile Ser Ala Ser Lys Ala Val Gly 
865                 870                 875                 880 


Trp Gly Ala Thr Gln Leu Val Glu Ala Ala Asp Lys Val Val Leu His 
                885                 890                 895     


Thr Gly Lys Tyr Glu Glu Leu Ile Val Cys Ser His Glu Ile Ala Ala 
            900                 905                 910         


Ser Thr Ala Gln Leu Val Ala Ala Ser Lys Val Lys Ala Asn Lys His 
        915                 920                 925             


Ser Pro His Leu Ser Arg Leu Gln Glu Cys Ser Arg Thr Val Asn Glu 
    930                 935                 940                 


Arg Ala Ala Asn Val Val Ala Ser Thr Lys Ser Gly Gln Glu Gln Ile 
945                 950                 955                 960 


Glu Asp Arg Asp Thr Met Asp Phe Ser Gly Leu Ser Leu Ile Lys Leu 
                965                 970                 975     


Lys Lys Gln Glu Met Glu Thr Gln Val Arg Val Leu Glu Leu Glu Lys 
            980                 985                 990         


Thr Leu Glu Ala Glu Arg Met Arg  Leu Gly Glu Leu Arg  Lys Gln His 
        995                 1000                 1005             


Tyr Val  Leu Ala Gly Ala Ser  Gly Ser Pro Gly Glu  Glu Val Ala 
    1010                 1015                 1020             


Ile Arg  Pro Ser Thr Ala Pro  Arg Ser Val Thr Thr  Lys Lys Pro 
    1025                 1030                 1035             


Pro Leu  Ala Gln Lys Pro Ser  Val Ala Pro Arg Gln  Asp His Gln 
    1040                 1045                 1050             


Leu Asp  Lys Lys Asp Gly Ile  Tyr Pro Ala Gln Leu  Val Asn Tyr 
    1055                 1060                 1065             


<210>  4990
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIPK1__Homo_sapiens__XP_011539282

<400>  4990

Met Thr Phe Tyr Ser Trp Ile Pro Tyr His Arg Gln Ala Pro Leu Asn 
1               5                   10                  15      


His Arg Arg Val Cys Ser Ala Glu Gly Ala Gly Ser Pro Gly Pro Ala 
            20                  25                  30          


Leu Asp Pro Arg Trp Leu Pro Thr Glu Ala His Leu Leu Glu Ala His 
        35                  40                  45              


Arg Leu Leu Leu Gln Ser Val Leu Cys Asp Arg Pro Arg Glu Ser Ile 
    50                  55                  60                  


Gln Leu His Phe Arg Leu Ser Met Ala Ser Gln Leu Gln Val Phe Ser 
65                  70                  75                  80  


Pro Pro Ser Val Ser Ser Ser Ala Phe Cys Ser Ala Lys Lys Leu Lys 
                85                  90                  95      


Ile Glu Pro Ser Gly Trp Asp Val Ser Gly Gln Ser Ser Asn Asp Lys 
            100                 105                 110         


Tyr Tyr Thr His Ser Lys Thr Leu Pro Ala Thr Gln Gly Gln Ala Asn 
        115                 120                 125             


Ser Ser His Gln Val Ala Asn Phe Asn Ile Pro Ala Tyr Asp Gln Gly 
    130                 135                 140                 


Leu Leu Leu Pro Ala Pro Ala Val Glu His Ile Val Val Thr Ala Ala 
145                 150                 155                 160 


Asp Ser Ser Gly Ser Ala Ala Thr Ser Thr Phe Gln Ser Ser Gln Thr 
                165                 170                 175     


Leu Thr His Arg Ser Asn Val Ser Leu Leu Glu Pro Tyr Gln Lys Cys 
            180                 185                 190         


Gly Leu Lys Arg Lys Ser Glu Glu Val Asp Ser Asn Gly Ser Val Gln 
        195                 200                 205             


Ile Ile Glu Glu His Pro Pro Leu Met Leu Gln Asn Arg Thr Val Val 
    210                 215                 220                 


Gly Ala Ala Ala Thr Thr Thr Thr Val Thr Thr Lys Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Gly Glu Gly Asp Tyr Gln Leu Val Gln His Glu Ile Leu Cys Ser 
                245                 250                 255     


Met Thr Asn Ser Tyr Glu Val Leu Glu Phe Leu Gly Arg Gly Thr Phe 
            260                 265                 270         


Gly Gln Val Ala Lys Cys Trp Lys Arg Ser Thr Lys Glu Ile Val Ala 
        275                 280                 285             


Ile Lys Ile Leu Lys Asn His Pro Ser Tyr Ala Arg Gln Gly Gln Ile 
    290                 295                 300                 


Glu Val Ser Ile Leu Ser Arg Leu Ser Ser Glu Asn Ala Asp Glu Tyr 
305                 310                 315                 320 


Asn Phe Val Arg Ser Tyr Glu Cys Phe Gln His Lys Asn His Thr Cys 
                325                 330                 335     


Leu Val Phe Glu Met Leu Glu Gln Asn Leu Tyr Asp Phe Leu Lys Gln 
            340                 345                 350         


Asn Lys Phe Ser Pro Leu Pro Leu Lys Tyr Ile Arg Pro Ile Leu Gln 
        355                 360                 365             


Gln Val Ala Thr Ala Leu Met Lys Leu Lys Ser Leu Gly Leu Ile His 
    370                 375                 380                 


Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val Asp Pro Val Arg Gln 
385                 390                 395                 400 


Pro Tyr Arg Val Lys Val Ile Asp Phe Gly Ser Ala Ser His Val Ser 
                405                 410                 415     


Lys Ala Val Cys Ser Thr Tyr Leu Gln Ser Arg Tyr Tyr Arg Ala Pro 
            420                 425                 430         


Glu Ile Ile Leu Gly Leu Pro Phe Cys Glu Ala Ile Asp Met Trp Ser 
        435                 440                 445             


Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro Leu Tyr Pro 
    450                 455                 460                 


Gly Ala Ser Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln Thr Gln Gly 
465                 470                 475                 480 


Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr Arg Phe 
                485                 490                 495     


Phe Asn Arg Asp Pro Asn Leu Gly Tyr Pro Leu Trp Arg Leu Lys Thr 
            500                 505                 510         


Pro Glu Glu His Glu Leu Glu Thr Gly Ile Lys Ser Lys Glu Ala Arg 
        515                 520                 525             


Lys Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn Met Ser 
    530                 535                 540                 


Thr Asp Leu Glu Gly Thr Asp Met Leu Ala Glu Lys Ala Asp Arg Arg 
545                 550                 555                 560 


Glu Tyr Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala Asp Lys 
                565                 570                 575     


Arg Ile Thr Pro Leu Lys Thr Leu Asn His Gln Phe Val Thr Met Thr 
            580                 585                 590         


His Leu Leu Asp Phe Pro His Ser Asn His Val Lys Ser Cys Phe Gln 
        595                 600                 605             


Asn Met Glu Ile Cys Lys Arg Arg Val His Met Tyr Asp Thr Val Ser 
    610                 615                 620                 


Gln Ile Lys Ser Pro Phe Thr Thr His Val Ala Pro Asn Thr Ser Thr 
625                 630                 635                 640 


Asn Leu Thr Met Ser Phe Ser Asn Gln Leu Asn Thr Val His Asn Gln 
                645                 650                 655     


Ala Ser Val Leu Ala Ser Ser Ser Thr Ala Ala Ala Ala Thr Leu Ser 
            660                 665                 670         


Leu Ala Asn Ser Asp Val Ser Leu Leu Asn Tyr Gln Ser Ala Leu Tyr 
        675                 680                 685             


Pro Ser Ser Ala Ala Pro Val Pro Gly Val Ala Gln Gln Gly Val Ser 
    690                 695                 700                 


Leu Gln Pro Gly Thr Thr Gln Ile Cys Thr Gln Thr Asp Pro Phe Gln 
705                 710                 715                 720 


Gln Thr Phe Ile Val Cys Pro Pro Ala Phe Gln Thr Gly Leu Gln Ala 
                725                 730                 735     


Thr Thr Lys His Ser Gly Phe Pro Val Arg Met Asp Asn Ala Val Pro 
            740                 745                 750         


Ile Val Pro Gln Ala Pro Ala Ala Gln Pro Leu Gln Ile Gln Ser Gly 
        755                 760                 765             


Val Leu Thr Gln Thr Cys Arg Glu Lys Ile Ser Arg His Ser 
    770                 775                 780         


<210>  4991
<211>  1171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIPK2__Homo_sapiens__NP_001106710

<400>  4991

Met Ala Pro Val Tyr Glu Gly Met Ala Ser His Val Gln Val Phe Ser 
1               5                   10                  15      


Pro His Thr Leu Gln Ser Ser Ala Phe Cys Ser Val Lys Lys Leu Lys 
            20                  25                  30          


Ile Glu Pro Ser Ser Asn Trp Asp Met Thr Gly Tyr Gly Ser His Ser 
        35                  40                  45              


Lys Val Tyr Ser Gln Ser Lys Asn Ile Pro Leu Ser Gln Pro Ala Thr 
    50                  55                  60                  


Thr Thr Val Ser Thr Ser Leu Pro Val Pro Asn Pro Ser Leu Pro Tyr 
65                  70                  75                  80  


Glu Gln Thr Ile Val Phe Pro Gly Ser Thr Gly His Ile Val Val Thr 
                85                  90                  95      


Ser Ala Ser Ser Thr Ser Val Thr Gly Gln Val Leu Gly Gly Pro His 
            100                 105                 110         


Asn Leu Met Arg Arg Ser Thr Val Ser Leu Leu Asp Thr Tyr Gln Lys 
        115                 120                 125             


Cys Gly Leu Lys Arg Lys Ser Glu Glu Ile Glu Asn Thr Ser Ser Val 
    130                 135                 140                 


Gln Ile Ile Glu Glu His Pro Pro Met Ile Gln Asn Asn Ala Ser Gly 
145                 150                 155                 160 


Ala Thr Val Ala Thr Ala Thr Thr Ser Thr Ala Thr Ser Lys Asn Ser 
                165                 170                 175     


Gly Ser Asn Ser Glu Gly Asp Tyr Gln Leu Val Gln His Glu Val Leu 
            180                 185                 190         


Cys Ser Met Thr Asn Thr Tyr Glu Val Leu Glu Phe Leu Gly Arg Gly 
        195                 200                 205             


Thr Phe Gly Gln Val Val Lys Cys Trp Lys Arg Gly Thr Asn Glu Ile 
    210                 215                 220                 


Val Ala Ile Lys Ile Leu Lys Asn His Pro Ser Tyr Ala Arg Gln Gly 
225                 230                 235                 240 


Gln Ile Glu Val Ser Ile Leu Ala Arg Leu Ser Thr Glu Ser Ala Asp 
                245                 250                 255     


Asp Tyr Asn Phe Val Arg Ala Tyr Glu Cys Phe Gln His Lys Asn His 
            260                 265                 270         


Thr Cys Leu Val Phe Glu Met Leu Glu Gln Asn Leu Tyr Asp Phe Leu 
        275                 280                 285             


Lys Gln Asn Lys Phe Ser Pro Leu Pro Leu Lys Tyr Ile Arg Pro Val 
    290                 295                 300                 


Leu Gln Gln Val Ala Thr Ala Leu Met Lys Leu Lys Ser Leu Gly Leu 
305                 310                 315                 320 


Ile His Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val Asp Pro Ser 
                325                 330                 335     


Arg Gln Pro Tyr Arg Val Lys Val Ile Asp Phe Gly Ser Ala Ser His 
            340                 345                 350         


Val Ser Lys Ala Val Cys Ser Thr Tyr Leu Gln Ser Arg Tyr Tyr Arg 
        355                 360                 365             


Ala Pro Glu Ile Ile Leu Gly Leu Pro Phe Cys Glu Ala Ile Asp Met 
    370                 375                 380                 


Trp Ser Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro Leu 
385                 390                 395                 400 


Tyr Pro Gly Ala Ser Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln Thr 
                405                 410                 415     


Gln Gly Leu Pro Ala Glu Tyr Leu Leu Ser Ala Gly Thr Lys Thr Thr 
            420                 425                 430         


Arg Phe Phe Asn Arg Asp Thr Asp Ser Pro Tyr Pro Leu Trp Arg Leu 
        435                 440                 445             


Lys Thr Pro Asp Asp His Glu Ala Glu Thr Gly Ile Lys Ser Lys Glu 
    450                 455                 460                 


Ala Arg Lys Tyr Ile Phe Asn Cys Leu Asp Asp Met Ala Gln Val Asn 
465                 470                 475                 480 


Met Thr Thr Asp Leu Glu Gly Ser Asp Met Leu Val Glu Lys Ala Asp 
                485                 490                 495     


Arg Arg Glu Phe Ile Asp Leu Leu Lys Lys Met Leu Thr Ile Asp Ala 
            500                 505                 510         


Asp Lys Arg Ile Thr Pro Ile Glu Thr Leu Asn His Pro Phe Val Thr 
        515                 520                 525             


Met Thr His Leu Leu Asp Phe Pro His Ser Thr His Val Lys Ser Cys 
    530                 535                 540                 


Phe Gln Asn Met Glu Ile Cys Lys Arg Arg Val Asn Met Tyr Asp Thr 
545                 550                 555                 560 


Val Asn Gln Ser Lys Thr Pro Phe Ile Thr His Val Ala Pro Ser Thr 
                565                 570                 575     


Ser Thr Asn Leu Thr Met Thr Phe Asn Asn Gln Leu Thr Thr Val His 
            580                 585                 590         


Asn Gln Pro Ser Ala Ala Ser Met Ala Ala Val Ala Gln Arg Ser Met 
        595                 600                 605             


Pro Leu Gln Thr Gly Thr Ala Gln Ile Cys Ala Arg Pro Asp Pro Phe 
    610                 615                 620                 


Gln Gln Ala Leu Ile Val Cys Pro Pro Gly Phe Gln Gly Leu Gln Ala 
625                 630                 635                 640 


Ser Pro Ser Lys His Ala Gly Tyr Ser Val Arg Met Glu Asn Ala Val 
                645                 650                 655     


Pro Ile Val Thr Gln Ala Pro Gly Ala Gln Pro Leu Gln Ile Gln Pro 
            660                 665                 670         


Gly Leu Leu Ala Gln Gln Ala Trp Pro Ser Gly Thr Gln Gln Ile Leu 
        675                 680                 685             


Leu Pro Pro Ala Trp Gln Gln Leu Thr Gly Val Ala Thr His Thr Ser 
    690                 695                 700                 


Val Gln His Ala Thr Val Ile Pro Glu Thr Met Ala Gly Thr Gln Gln 
705                 710                 715                 720 


Leu Ala Asp Trp Arg Asn Thr His Ala His Gly Ser His Tyr Asn Pro 
                725                 730                 735     


Ile Met Gln Gln Pro Ala Leu Leu Thr Gly His Val Thr Leu Pro Ala 
            740                 745                 750         


Ala Gln Pro Leu Asn Val Gly Val Ala His Val Met Arg Gln Gln Pro 
        755                 760                 765             


Thr Ser Thr Thr Ser Ser Arg Lys Ser Lys Gln His Gln Ser Ser Val 
    770                 775                 780                 


Arg Asn Val Ser Thr Cys Glu Val Ser Ser Ser Gln Ala Ile Ser Ser 
785                 790                 795                 800 


Pro Gln Arg Ser Lys Arg Val Lys Glu Asn Thr Pro Pro Arg Cys Ala 
                805                 810                 815     


Met Val His Ser Ser Pro Ala Cys Ser Thr Ser Val Thr Cys Gly Trp 
            820                 825                 830         


Gly Asp Val Ala Ser Ser Thr Thr Arg Glu Arg Gln Arg Gln Thr Ile 
        835                 840                 845             


Val Ile Pro Asp Thr Pro Ser Pro Thr Val Ser Val Ile Thr Ile Ser 
    850                 855                 860                 


Ser Asp Thr Asp Glu Glu Glu Glu Gln Lys His Ala Pro Thr Ser Thr 
865                 870                 875                 880 


Val Ser Lys Gln Arg Lys Asn Val Ile Ser Cys Val Thr Val His Asp 
                885                 890                 895     


Ser Pro Tyr Ser Asp Ser Ser Ser Asn Thr Ser Pro Tyr Ser Val Gln 
            900                 905                 910         


Gln Arg Ala Gly His Asn Asn Ala Asn Ala Phe Asp Thr Lys Gly Ser 
        915                 920                 925             


Leu Glu Asn His Cys Thr Gly Asn Pro Arg Thr Ile Ile Val Pro Pro 
    930                 935                 940                 


Leu Lys Thr Gln Ala Ser Glu Val Leu Val Glu Cys Asp Ser Leu Val 
945                 950                 955                 960 


Pro Val Asn Thr Ser His His Ser Ser Ser Tyr Lys Ser Lys Ser Ser 
                965                 970                 975     


Ser Asn Val Thr Ser Thr Ser Gly His Ser Ser Gly Ser Ser Ser Gly 
            980                 985                 990         


Ala Ile Thr Tyr Arg Gln Gln Arg  Pro Gly Pro His Phe  Gln Gln Gln 
        995                 1000                 1005             


Gln Pro  Leu Asn Leu Ser Gln  Ala Gln Gln His Ile  Thr Thr Asp 
    1010                 1015                 1020             


Arg Thr  Gly Ser His Arg Arg  Gln Gln Ala Tyr Ile  Thr Pro Thr 
    1025                 1030                 1035             


Met Ala  Gln Ala Pro Tyr Ser  Phe Pro His Asn Ser  Pro Ser His 
    1040                 1045                 1050             


Gly Thr  Val His Pro His Leu  Ala Ala Ala Ala Ala  Ala Ala His 
    1055                 1060                 1065             


Leu Pro  Thr Gln Pro His Leu  Tyr Thr Tyr Thr Ala  Pro Ala Ala 
    1070                 1075                 1080             


Leu Gly  Ser Thr Gly Thr Val  Ala His Leu Val Ala  Ser Gln Gly 
    1085                 1090                 1095             


Ser Ala  Arg His Thr Val Gln  His Thr Ala Tyr Pro  Ala Ser Ile 
    1100                 1105                 1110             


Val His  Gln Val Pro Val Ser  Met Gly Pro Arg Val  Leu Pro Ser 
    1115                 1120                 1125             


Pro Thr  Ile His Pro Ser Gln  Tyr Pro Ala Gln Phe  Ala His Gln 
    1130                 1135                 1140             


Thr Tyr  Ile Ser Ala Ser Pro  Ala Ser Thr Val Tyr  Thr Gly Tyr 
    1145                 1150                 1155             


Pro Leu  Ser Pro Ala Lys Val  Asn Gln Tyr Pro Tyr  Ile 
    1160                 1165                 1170     


<210>  4992
<211>  1194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIPK3__Homo_sapiens__NP_001265092

<400>  4992

Met Ala Ser Gln Val Leu Val Tyr Pro Pro Tyr Val Tyr Gln Thr Gln 
1               5                   10                  15      


Ser Ser Ala Phe Cys Ser Val Lys Lys Leu Lys Val Glu Pro Ser Ser 
            20                  25                  30          


Cys Val Phe Gln Glu Arg Asn Tyr Pro Arg Thr Tyr Val Asn Gly Arg 
        35                  40                  45              


Asn Phe Gly Asn Ser His Pro Pro Thr Lys Gly Ser Ala Phe Gln Thr 
    50                  55                  60                  


Lys Ile Pro Phe Asn Arg Pro Arg Gly His Asn Phe Ser Leu Gln Thr 
65                  70                  75                  80  


Ser Ala Val Val Leu Lys Asn Thr Ala Gly Ala Thr Lys Val Ile Ala 
                85                  90                  95      


Ala Gln Ala Gln Gln Ala His Val Gln Ala Pro Gln Ile Gly Ala Trp 
            100                 105                 110         


Arg Asn Arg Leu His Phe Leu Glu Gly Pro Gln Arg Cys Gly Leu Lys 
        115                 120                 125             


Arg Lys Ser Glu Glu Leu Asp Asn His Ser Ser Ala Met Gln Ile Val 
    130                 135                 140                 


Asp Glu Leu Ser Ile Leu Pro Ala Met Leu Gln Thr Asn Met Gly Asn 
145                 150                 155                 160 


Pro Val Thr Val Val Thr Ala Thr Thr Gly Ser Lys Gln Asn Cys Thr 
                165                 170                 175     


Thr Gly Glu Gly Asp Tyr Gln Leu Val Gln His Glu Val Leu Cys Ser 
            180                 185                 190         


Met Lys Asn Thr Tyr Glu Val Leu Asp Phe Leu Gly Arg Gly Thr Phe 
        195                 200                 205             


Gly Gln Val Val Lys Cys Trp Lys Arg Gly Thr Asn Glu Ile Val Ala 
    210                 215                 220                 


Ile Lys Ile Leu Lys Asn His Pro Ser Tyr Ala Arg Gln Gly Gln Ile 
225                 230                 235                 240 


Glu Val Ser Ile Leu Ala Arg Leu Ser Thr Glu Asn Ala Asp Glu Tyr 
                245                 250                 255     


Asn Phe Val Arg Ala Tyr Glu Cys Phe Gln His Arg Asn His Thr Cys 
            260                 265                 270         


Leu Val Phe Glu Met Leu Glu Gln Asn Leu Tyr Asp Phe Leu Lys Gln 
        275                 280                 285             


Asn Lys Phe Ser Pro Leu Pro Leu Lys Val Ile Arg Pro Ile Leu Gln 
    290                 295                 300                 


Gln Val Ala Thr Ala Leu Lys Lys Leu Lys Ser Leu Gly Leu Ile His 
305                 310                 315                 320 


Ala Asp Leu Lys Pro Glu Asn Ile Met Leu Val Asp Pro Val Arg Gln 
                325                 330                 335     


Pro Tyr Arg Val Lys Val Ile Asp Phe Gly Ser Ala Ser His Val Ser 
            340                 345                 350         


Lys Thr Val Cys Ser Thr Tyr Leu Gln Ser Arg Tyr Tyr Arg Ala Pro 
        355                 360                 365             


Glu Ile Ile Leu Gly Leu Pro Phe Cys Glu Ala Ile Asp Met Trp Ser 
    370                 375                 380                 


Leu Gly Cys Val Ile Ala Glu Leu Phe Leu Gly Trp Pro Leu Tyr Pro 
385                 390                 395                 400 


Gly Ala Leu Glu Tyr Asp Gln Ile Arg Tyr Ile Ser Gln Thr Gln Gly 
                405                 410                 415     


Leu Pro Gly Glu Gln Leu Leu Asn Val Gly Thr Lys Ser Thr Arg Phe 
            420                 425                 430         


Phe Cys Lys Glu Thr Asp Met Ser His Ser Gly Trp Arg Leu Lys Thr 
        435                 440                 445             


Leu Glu Glu His Glu Ala Glu Thr Gly Met Lys Ser Lys Glu Ala Arg 
    450                 455                 460                 


Lys Tyr Ile Phe Asn Ser Leu Asp Asp Val Ala His Val Asn Thr Val 
465                 470                 475                 480 


Met Asp Leu Glu Gly Ser Asp Leu Leu Ala Glu Lys Ala Asp Arg Arg 
                485                 490                 495     


Glu Phe Val Ser Leu Leu Lys Lys Met Leu Leu Ile Asp Ala Asp Leu 
            500                 505                 510         


Arg Ile Thr Pro Ala Glu Thr Leu Asn His Pro Phe Val Asn Met Lys 
        515                 520                 525             


His Leu Leu Asp Phe Pro His Ser Asn His Val Lys Ser Cys Phe His 
    530                 535                 540                 


Ile Met Asp Ile Cys Lys Ser His Leu Asn Ser Cys Asp Thr Asn Asn 
545                 550                 555                 560 


His Asn Lys Thr Ser Leu Leu Arg Pro Val Ala Ser Ser Ser Thr Ala 
                565                 570                 575     


Thr Leu Thr Ala Asn Phe Thr Lys Ile Gly Thr Leu Arg Ser Gln Ala 
            580                 585                 590         


Leu Thr Thr Ser Ala His Ser Val Val His His Gly Ile Pro Leu Gln 
        595                 600                 605             


Ala Gly Thr Ala Gln Phe Gly Cys Gly Asp Ala Phe Gln Gln Thr Leu 
    610                 615                 620                 


Ile Ile Cys Pro Pro Ala Ile Gln Gly Ile Pro Ala Thr His Gly Lys 
625                 630                 635                 640 


Pro Thr Ser Tyr Ser Ile Arg Val Asp Asn Thr Val Pro Leu Val Thr 
                645                 650                 655     


Gln Ala Pro Ala Val Gln Pro Leu Gln Ile Arg Pro Gly Val Leu Ser 
            660                 665                 670         


Gln Thr Trp Ser Gly Arg Thr Gln Gln Met Leu Val Pro Ala Trp Gln 
        675                 680                 685             


Gln Val Thr Pro Leu Ala Pro Ala Thr Thr Thr Leu Thr Ser Glu Ser 
    690                 695                 700                 


Val Ala Gly Ser His Arg Leu Gly Asp Trp Gly Lys Met Ile Ser Cys 
705                 710                 715                 720 


Ser Asn His Tyr Asn Ser Val Met Pro Gln Pro Leu Leu Thr Asn Gln 
                725                 730                 735     


Ile Thr Leu Ser Ala Pro Gln Pro Val Ser Val Gly Ile Ala His Val 
            740                 745                 750         


Val Trp Pro Gln Pro Ala Thr Thr Lys Lys Asn Lys Gln Cys Gln Asn 
        755                 760                 765             


Arg Ser Asn Ser Leu Gln Asn Thr Asn Ile Pro His Ser Ala Phe Ile 
    770                 775                 780                 


Ser Pro Lys Ile Ile Asn Gly Lys Asp Val Glu Glu Val Ser Cys Ile 
785                 790                 795                 800 


Glu Thr Gln Asp Asn Gln Asn Ser Glu Gly Glu Ala Arg Asn Cys Cys 
                805                 810                 815     


Glu Thr Ser Ile Arg Gln Asp Ser Asp Ser Ser Val Ser Asp Lys Gln 
            820                 825                 830         


Arg Gln Thr Ile Ile Ile Ala Asp Ser Pro Ser Pro Ala Val Ser Val 
        835                 840                 845             


Ile Thr Ile Ser Ser Asp Thr Asp Glu Glu Glu Thr Ser Gln Arg His 
    850                 855                 860                 


Ser Leu Arg Glu Cys Lys Gly Ser Leu Asp Cys Glu Ala Cys Gln Ser 
865                 870                 875                 880 


Thr Leu Asn Ile Asp Arg Met Cys Ser Leu Ser Ser Pro Asp Ser Thr 
                885                 890                 895     


Leu Ser Thr Ser Ser Ser Gly Gln Ser Ser Pro Ser Pro Cys Lys Arg 
            900                 905                 910         


Pro Asn Ser Met Ser Asp Glu Glu Gln Glu Ser Ser Cys Asp Thr Val 
        915                 920                 925             


Asp Gly Ser Pro Thr Ser Asp Ser Ser Gly His Asp Ser Pro Phe Ala 
    930                 935                 940                 


Glu Ser Thr Phe Val Glu Asp Thr His Glu Asn Thr Glu Leu Val Ser 
945                 950                 955                 960 


Ser Ala Asp Thr Glu Thr Lys Pro Ala Val Cys Ser Val Val Val Pro 
                965                 970                 975     


Pro Val Glu Leu Glu Asn Gly Leu Asn Ala Asp Glu His Met Ala Asn 
            980                 985                 990         


Thr Asp Ser Ile Cys Gln Pro Leu  Ile Lys Gly Arg Ser  Ala Pro Gly 
        995                 1000                 1005             


Arg Leu  Asn Gln Pro Ser Ala  Val Gly Thr Arg Gln  Gln Lys Leu 
    1010                 1015                 1020             


Thr Ser  Ala Phe Gln Gln Gln  His Leu Asn Phe Ser  Gln Val Gln 
    1025                 1030                 1035             


His Phe  Gly Ser Gly His Gln  Glu Trp Asn Gly Asn  Phe Gly His 
    1040                 1045                 1050             


Arg Arg  Gln Gln Ala Tyr Ile  Pro Thr Ser Val Thr  Ser Asn Pro 
    1055                 1060                 1065             


Phe Thr  Leu Ser His Gly Ser  Pro Asn His Thr Ala  Val His Ala 
    1070                 1075                 1080             


His Leu  Ala Gly Asn Thr His  Leu Gly Gly Gln Pro  Thr Leu Leu 
    1085                 1090                 1095             


Pro Tyr  Pro Ser Ser Ala Thr  Leu Ser Ser Ala Ala  Pro Val Ala 
    1100                 1105                 1110             


His Leu  Leu Ala Ser Pro Cys  Thr Ser Arg Pro Met  Leu Gln His 
    1115                 1120                 1125             


Pro Thr  Tyr Asn Ile Ser His  Pro Ser Gly Ile Val  His Gln Val 
    1130                 1135                 1140             


Pro Val  Gly Leu Asn Pro Arg  Leu Leu Pro Ser Pro  Thr Ile His 
    1145                 1150                 1155             


Gln Thr  Gln Tyr Lys Pro Ile  Phe Pro Pro His Ser  Tyr Ile Ala 
    1160                 1165                 1170             


Ala Ser  Pro Ala Tyr Thr Gly  Phe Pro Leu Ser Pro  Thr Lys Leu 
    1175                 1180                 1185             


Ser Gln  Tyr Pro Tyr Met 
    1190                 


<210>  4993
<211>  1017
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIRA__Homo_sapiens__NP_003316

<400>  4993

Met Lys Leu Leu Lys Pro Thr Trp Val Asn His Asn Gly Lys Pro Ile 
1               5                   10                  15      


Phe Ser Val Asp Ile His Pro Asp Gly Thr Lys Phe Ala Thr Gly Gly 
            20                  25                  30          


Gln Gly Gln Asp Ser Gly Lys Val Val Ile Trp Asn Met Ser Pro Val 
        35                  40                  45              


Leu Gln Glu Asp Asp Glu Lys Asp Glu Asn Ile Pro Lys Met Leu Cys 
    50                  55                  60                  


Gln Met Asp Asn His Leu Ala Cys Val Asn Cys Val Arg Trp Ser Asn 
65                  70                  75                  80  


Ser Gly Met Tyr Leu Ala Ser Gly Gly Asp Asp Lys Leu Ile Met Val 
                85                  90                  95      


Trp Lys Arg Ala Thr Tyr Ile Gly Pro Ser Thr Val Phe Gly Ser Ser 
            100                 105                 110         


Gly Lys Leu Ala Asn Val Glu Gln Trp Arg Cys Val Ser Ile Leu Arg 
        115                 120                 125             


Asn His Ser Gly Asp Val Met Asp Val Ala Trp Ser Pro His Asp Ala 
    130                 135                 140                 


Trp Leu Ala Ser Cys Ser Val Asp Asn Thr Val Val Ile Trp Asn Ala 
145                 150                 155                 160 


Val Lys Phe Pro Glu Ile Leu Ala Thr Leu Arg Gly His Ser Gly Leu 
                165                 170                 175     


Val Lys Gly Leu Thr Trp Asp Pro Val Gly Lys Tyr Ile Ala Ser Gln 
            180                 185                 190         


Ala Asp Asp Arg Ser Leu Lys Val Trp Arg Thr Leu Asp Trp Gln Leu 
        195                 200                 205             


Glu Thr Ser Ile Thr Lys Pro Phe Asp Glu Cys Gly Gly Thr Thr His 
    210                 215                 220                 


Val Leu Arg Leu Ser Trp Ser Pro Asp Gly His Tyr Leu Val Ser Ala 
225                 230                 235                 240 


His Ala Met Asn Asn Ser Gly Pro Thr Ala Gln Ile Ile Glu Arg Glu 
                245                 250                 255     


Gly Trp Lys Thr Asn Met Asp Phe Val Gly His Arg Lys Ala Val Thr 
            260                 265                 270         


Val Val Lys Phe Asn Pro Lys Ile Phe Lys Lys Lys Gln Lys Asn Gly 
        275                 280                 285             


Ser Ser Ala Lys Pro Ser Cys Pro Tyr Cys Cys Cys Ala Val Gly Ser 
    290                 295                 300                 


Lys Asp Arg Ser Leu Ser Val Trp Leu Thr Cys Leu Lys Arg Pro Leu 
305                 310                 315                 320 


Val Val Ile His Glu Leu Phe Asp Lys Ser Ile Met Asp Ile Ser Trp 
                325                 330                 335     


Thr Leu Asn Gly Leu Gly Ile Leu Val Cys Ser Met Asp Gly Ser Val 
            340                 345                 350         


Ala Phe Leu Asp Phe Ser Gln Asp Glu Leu Gly Asp Pro Leu Ser Glu 
        355                 360                 365             


Glu Glu Lys Ser Arg Ile His Gln Ser Thr Tyr Gly Lys Ser Leu Ala 
    370                 375                 380                 


Ile Met Thr Glu Ala Gln Leu Ser Thr Ala Val Ile Glu Asn Pro Glu 
385                 390                 395                 400 


Met Leu Lys Tyr Gln Arg Arg Gln Gln Gln Gln Gln Leu Asp Gln Lys 
                405                 410                 415     


Ser Ala Ala Thr Arg Glu Met Gly Ser Ala Thr Ser Val Ala Gly Val 
            420                 425                 430         


Val Asn Gly Glu Ser Leu Glu Asp Ile Arg Lys Asn Leu Leu Lys Lys 
        435                 440                 445             


Gln Val Glu Thr Arg Thr Ala Asp Gly Arg Arg Arg Ile Thr Pro Leu 
    450                 455                 460                 


Cys Ile Ala Gln Leu Asp Thr Gly Asp Phe Ser Thr Ala Phe Phe Asn 
465                 470                 475                 480 


Ser Ile Pro Leu Ser Gly Ser Leu Ala Gly Thr Met Leu Ser Ser His 
                485                 490                 495     


Ser Ser Pro Gln Leu Leu Pro Leu Asp Ser Ser Thr Pro Asn Ser Phe 
            500                 505                 510         


Gly Ala Ser Lys Pro Cys Thr Glu Pro Val Val Ala Ala Ser Ala Arg 
        515                 520                 525             


Pro Ala Gly Asp Ser Val Asn Lys Asp Ser Met Asn Ala Thr Ser Thr 
    530                 535                 540                 


Pro Ala Ala Leu Ser Pro Ser Val Leu Thr Thr Pro Ser Lys Ile Glu 
545                 550                 555                 560 


Pro Met Lys Ala Phe Asp Ser Arg Phe Thr Glu Arg Ser Lys Ala Thr 
                565                 570                 575     


Pro Gly Ala Pro Ala Leu Thr Ser Met Thr Pro Thr Ala Val Glu Arg 
            580                 585                 590         


Leu Lys Glu Gln Asn Leu Val Lys Glu Leu Arg Pro Arg Asp Leu Leu 
        595                 600                 605             


Glu Ser Ser Ser Asp Ser Asp Glu Lys Val Pro Leu Ala Lys Ala Ser 
    610                 615                 620                 


Ser Leu Ser Lys Arg Lys Leu Glu Leu Glu Val Glu Thr Val Glu Lys 
625                 630                 635                 640 


Lys Lys Lys Gly Arg Pro Arg Lys Asp Ser Arg Leu Met Pro Val Ser 
                645                 650                 655     


Leu Ser Val Gln Ser Pro Ala Ala Leu Thr Ala Glu Lys Glu Ala Met 
            660                 665                 670         


Cys Leu Ser Ala Pro Ala Leu Ala Leu Lys Leu Pro Ile Pro Ser Pro 
        675                 680                 685             


Gln Arg Ala Phe Thr Leu Gln Val Ser Ser Asp Pro Ser Met Tyr Ile 
    690                 695                 700                 


Glu Val Glu Asn Glu Val Thr Val Val Gly Gly Val Lys Leu Ser Arg 
705                 710                 715                 720 


Leu Lys Cys Asn Arg Glu Gly Lys Glu Trp Glu Thr Val Leu Thr Ser 
                725                 730                 735     


Arg Ile Leu Thr Ala Ala Gly Ser Cys Asp Val Val Cys Val Ala Cys 
            740                 745                 750         


Glu Lys Arg Met Leu Ser Val Phe Ser Thr Cys Gly Arg Arg Leu Leu 
        755                 760                 765             


Ser Pro Ile Leu Leu Pro Ser Pro Ile Ser Thr Leu His Cys Thr Gly 
    770                 775                 780                 


Ser Tyr Val Met Ala Leu Thr Ala Ala Ala Thr Leu Ser Val Trp Asp 
785                 790                 795                 800 


Val His Arg Gln Val Val Val Val Lys Glu Glu Ser Leu His Ser Ile 
                805                 810                 815     


Leu Ala Gly Ser Asp Met Thr Val Ser Gln Ile Leu Leu Thr Gln His 
            820                 825                 830         


Gly Ile Pro Val Met Asn Leu Ser Asp Gly Lys Ala Tyr Cys Phe Asn 
        835                 840                 845             


Pro Ser Leu Ser Thr Trp Asn Leu Val Ser Asp Lys Gln Asp Ser Leu 
    850                 855                 860                 


Ala Gln Cys Ala Asp Phe Arg Ser Ser Leu Pro Ser Gln Asp Ala Met 
865                 870                 875                 880 


Leu Cys Ser Gly Pro Leu Ala Ile Ile Gln Gly Arg Thr Ser Asn Ser 
                885                 890                 895     


Gly Arg Gln Ala Ala Arg Leu Phe Ser Val Pro His Val Val Gln Gln 
            900                 905                 910         


Glu Thr Thr Leu Ala Tyr Leu Glu Asn Gln Val Ala Ala Ala Leu Thr 
        915                 920                 925             


Leu Gln Ser Ser His Glu Tyr Arg His Trp Leu Leu Val Tyr Ala Arg 
    930                 935                 940                 


Tyr Leu Val Asn Glu Gly Phe Glu Tyr Arg Leu Arg Glu Ile Cys Lys 
945                 950                 955                 960 


Asp Leu Leu Gly Pro Val His Tyr Ser Thr Gly Ser Gln Trp Glu Ser 
                965                 970                 975     


Thr Val Val Gly Leu Arg Lys Arg Glu Leu Leu Lys Glu Leu Leu Pro 
            980                 985                 990         


Val Ile Gly Gln Asn Leu Arg Phe  Gln Arg Leu Phe Thr  Glu Cys Gln 
        995                 1000                 1005             


Glu Gln  Leu Asp Ile Leu Arg  Asp Lys 
    1010                 1015         


<210>  4994
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIRIP3__Homo_sapiens__NP_003600

<400>  4994

Met Ala Arg Glu Lys Glu Met Gln Glu Phe Thr Arg Ser Phe Phe Arg 
1               5                   10                  15      


Gly Arg Pro Asp Leu Ser Thr Leu Thr His Ser Ile Val Arg Arg Arg 
            20                  25                  30          


Tyr Leu Ala His Ser Gly Arg Ser His Leu Glu Pro Glu Glu Lys Gln 
        35                  40                  45              


Ala Leu Lys Arg Leu Val Glu Glu Glu Leu Leu Lys Met Gln Val Asp 
    50                  55                  60                  


Glu Ala Ala Ser Arg Glu Asp Lys Leu Asp Leu Thr Lys Lys Gly Lys 
65                  70                  75                  80  


Arg Pro Pro Thr Pro Cys Ser Asp Pro Glu Arg Lys Arg Phe Arg Phe 
                85                  90                  95      


Asn Ser Glu Ser Glu Ser Gly Ser Glu Ala Ser Ser Pro Asp Tyr Phe 
            100                 105                 110         


Gly Pro Pro Ala Lys Asn Gly Val Ala Ala Glu Val Ser Pro Ala Lys 
        115                 120                 125             


Glu Glu Asn Pro Arg Arg Ala Ser Lys Ala Val Glu Glu Ser Ser Asp 
    130                 135                 140                 


Glu Glu Arg Gln Arg Asp Leu Pro Ala Gln Arg Gly Glu Glu Ser Ser 
145                 150                 155                 160 


Glu Glu Glu Glu Lys Gly Tyr Lys Gly Lys Thr Arg Lys Lys Pro Val 
                165                 170                 175     


Val Lys Lys Gln Ala Pro Gly Lys Ala Ser Val Ser Arg Lys Gln Ala 
            180                 185                 190         


Arg Glu Glu Ser Glu Glu Ser Glu Ala Glu Pro Val Gln Arg Thr Ala 
        195                 200                 205             


Lys Lys Val Glu Gly Asn Lys Gly Thr Lys Ser Leu Lys Glu Ser Glu 
    210                 215                 220                 


Gln Glu Ser Glu Glu Glu Ile Leu Ala Gln Lys Lys Glu Gln Arg Glu 
225                 230                 235                 240 


Glu Glu Val Glu Glu Glu Glu Lys Glu Glu Asp Glu Glu Lys Gly Asp 
                245                 250                 255     


Trp Lys Pro Arg Thr Arg Ser Asn Gly Arg Arg Lys Ser Ala Arg Glu 
            260                 265                 270         


Glu Arg Ser Cys Lys Gln Lys Ser Gln Ala Lys Arg Leu Leu Gly Asp 
        275                 280                 285             


Ser Asp Ser Glu Glu Glu Gln Lys Glu Ala Ala Ser Ser Gly Asp Asp 
    290                 295                 300                 


Ser Gly Arg Asp Arg Glu Pro Pro Val Gln Arg Lys Ser Glu Asp Arg 
305                 310                 315                 320 


Thr Gln Leu Lys Gly Gly Lys Arg Leu Ser Gly Ser Ser Glu Asp Glu 
                325                 330                 335     


Glu Asp Ser Gly Lys Gly Glu Pro Thr Ala Lys Gly Ser Arg Lys Met 
            340                 345                 350         


Ala Arg Leu Gly Ser Thr Ser Gly Glu Glu Ser Asp Leu Glu Arg Glu 
        355                 360                 365             


Val Ser Asp Ser Glu Ala Gly Gly Gly Pro Gln Gly Glu Arg Lys Asn 
    370                 375                 380                 


Arg Ser Ser Lys Lys Ser Ser Arg Lys Gly Arg Thr Arg Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Asp Gly Ser Pro Glu Ala Lys Gly Gly Lys Ala Gly Ser 
                405                 410                 415     


Gly Arg Arg Gly Glu Asp His Pro Ala Val Met Arg Leu Lys Arg Tyr 
            420                 425                 430         


Ile Arg Ala Cys Gly Ala His Arg Asn Tyr Lys Lys Leu Leu Gly Ser 
        435                 440                 445             


Cys Cys Ser His Lys Glu Arg Leu Ser Ile Leu Arg Ala Glu Leu Glu 
    450                 455                 460                 


Ala Leu Gly Met Lys Gly Thr Pro Ser Leu Gly Lys Cys Arg Ala Leu 
465                 470                 475                 480 


Lys Glu Gln Arg Glu Glu Ala Ala Glu Val Ala Ser Leu Asp Val Ala 
                485                 490                 495     


Asn Ile Ile Ser Gly Ser Gly Arg Pro Arg Arg Arg Thr Ala Trp Asn 
            500                 505                 510         


Pro Leu Gly Glu Ala Ala Pro Pro Gly Glu Leu Tyr Arg Arg Thr Leu 
        515                 520                 525             


Asp Ser Asp Glu Glu Arg Pro Arg Pro Ala Pro Pro Asp Trp Ser His 
    530                 535                 540                 


Met Arg Gly Ile Ile Ser Ser Asp Gly Glu Ser Asn 
545                 550                 555     


<210>  4995
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H1A__Homo_sapiens__NP_005316

<400>  4995

Met Ser Glu Thr Val Pro Pro Ala Pro Ala Ala Ser Ala Ala Pro Glu 
1               5                   10                  15      


Lys Pro Leu Ala Gly Lys Lys Ala Lys Lys Pro Ala Lys Ala Ala Ala 
            20                  25                  30          


Ala Ser Lys Lys Lys Pro Ala Gly Pro Ser Val Ser Glu Leu Ile Val 
        35                  40                  45              


Gln Ala Ala Ser Ser Ser Lys Glu Arg Gly Gly Val Ser Leu Ala Ala 
    50                  55                  60                  


Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn 
65                  70                  75                  80  


Ser Arg Ile Lys Leu Gly Ile Lys Ser Leu Val Ser Lys Gly Thr Leu 
                85                  90                  95      


Val Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys 
            100                 105                 110         


Lys Ala Ser Ser Val Glu Thr Lys Pro Gly Ala Ser Lys Val Ala Thr 
        115                 120                 125             


Lys Thr Lys Ala Thr Gly Ala Ser Lys Lys Leu Lys Lys Ala Thr Gly 
    130                 135                 140                 


Ala Ser Lys Lys Ser Val Lys Thr Pro Lys Lys Ala Lys Lys Pro Ala 
145                 150                 155                 160 


Ala Thr Arg Lys Ser Ser Lys Asn Pro Lys Lys Pro Lys Thr Val Lys 
                165                 170                 175     


Pro Lys Lys Val Ala Lys Ser Pro Ala Lys Ala Lys Ala Val Lys Pro 
            180                 185                 190         


Lys Ala Ala Lys Ala Arg Val Thr Lys Pro Lys Thr Ala Lys Pro Lys 
        195                 200                 205             


Lys Ala Ala Pro Lys Lys Lys 
    210                 215 


<210>  4996
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H1B__Homo_sapiens__NP_005313

<400>  4996

Met Ser Glu Thr Ala Pro Ala Glu Thr Ala Thr Pro Ala Pro Val Glu 
1               5                   10                  15      


Lys Ser Pro Ala Lys Lys Lys Ala Thr Lys Lys Ala Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Lys Arg Lys Ala Thr Gly Pro Pro Val Ser Glu Leu Ile Thr 
        35                  40                  45              


Lys Ala Val Ala Ala Ser Lys Glu Arg Asn Gly Leu Ser Leu Ala Ala 
    50                  55                  60                  


Leu Lys Lys Ala Leu Ala Ala Gly Gly Tyr Asp Val Glu Lys Asn Asn 
65                  70                  75                  80  


Ser Arg Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu 
                85                  90                  95      


Val Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys 
            100                 105                 110         


Lys Ala Ala Ser Gly Glu Ala Lys Pro Lys Ala Lys Lys Ala Gly Ala 
        115                 120                 125             


Ala Lys Ala Lys Lys Pro Ala Gly Ala Thr Pro Lys Lys Ala Lys Lys 
    130                 135                 140                 


Ala Ala Gly Ala Lys Lys Ala Val Lys Lys Thr Pro Lys Lys Ala Lys 
145                 150                 155                 160 


Lys Pro Ala Ala Ala Gly Val Lys Lys Val Ala Lys Ser Pro Lys Lys 
                165                 170                 175     


Ala Lys Ala Ala Ala Lys Pro Lys Lys Ala Thr Lys Ser Pro Ala Lys 
            180                 185                 190         


Pro Lys Ala Val Lys Pro Lys Ala Ala Lys Pro Lys Ala Ala Lys Pro 
        195                 200                 205             


Lys Ala Ala Lys Pro Lys Ala Ala Lys Ala Lys Lys Ala Ala Ala Lys 
    210                 215                 220                 


Lys Lys 
225     


<210>  4997
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H1C__Homo_sapiens__NP_005310

<400>  4997

Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Ala Pro Pro Ala Glu 
1               5                   10                  15      


Lys Ala Pro Val Lys Lys Lys Ala Ala Lys Lys Ala Gly Gly Thr Pro 
            20                  25                  30          


Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val 
        35                  40                  45              


Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys 
    50                  55                  60                  


Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr 
                85                  90                  95      


Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala 
            100                 105                 110         


Ser Gly Glu Ala Lys Pro Lys Val Lys Lys Ala Gly Gly Thr Lys Pro 
        115                 120                 125             


Lys Lys Pro Val Gly Ala Ala Lys Lys Pro Lys Lys Ala Ala Gly Gly 
    130                 135                 140                 


Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys 
145                 150                 155                 160 


Pro Ala Ala Ala Thr Val Thr Lys Lys Val Ala Lys Ser Pro Lys Lys 
                165                 170                 175     


Ala Lys Val Ala Lys Pro Lys Lys Ala Ala Lys Ser Ala Ala Lys Ala 
            180                 185                 190         


Val Lys Pro Lys Ala Ala Lys Pro Lys Val Val Lys Pro Lys Lys Ala 
        195                 200                 205             


Ala Pro Lys Lys Lys 
    210             


<210>  4998
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H1D__Homo_sapiens__NP_005311

<400>  4998

Met Ser Glu Thr Ala Pro Leu Ala Pro Thr Ile Pro Ala Pro Ala Glu 
1               5                   10                  15      


Lys Thr Pro Val Lys Lys Lys Ala Lys Lys Ala Gly Ala Thr Ala Gly 
            20                  25                  30          


Lys Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala 
        35                  40                  45              


Val Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys 
    50                  55                  60                  


Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg 
65                  70                  75                  80  


Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln 
                85                  90                  95      


Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala 
            100                 105                 110         


Ala Ser Gly Glu Gly Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala Lys 
        115                 120                 125             


Pro Arg Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Val Ala Gly 
    130                 135                 140                 


Ala Ala Thr Pro Lys Lys Ser Ile Lys Lys Thr Pro Lys Lys Val Lys 
145                 150                 155                 160 


Lys Pro Ala Thr Ala Ala Gly Thr Lys Lys Val Ala Lys Ser Ala Lys 
                165                 170                 175     


Lys Val Lys Thr Pro Gln Pro Lys Lys Ala Ala Lys Ser Pro Ala Lys 
            180                 185                 190         


Ala Lys Ala Pro Lys Pro Lys Ala Ala Lys Pro Lys Ser Gly Lys Pro 
        195                 200                 205             


Lys Val Thr Lys Ala Lys Lys Ala Ala Pro Lys Lys Lys 
    210                 215                 220     


<210>  4999
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H1E__Homo_sapiens__NP_005312

<400>  4999

Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu 
1               5                   10                  15      


Lys Thr Pro Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala Lys 
            20                  25                  30          


Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val 
        35                  40                  45              


Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys 
    50                  55                  60                  


Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr 
                85                  90                  95      


Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala 
            100                 105                 110         


Ser Gly Glu Ala Lys Pro Lys Ala Lys Lys Ala Gly Ala Ala Lys Ala 
        115                 120                 125             


Lys Lys Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Ala Thr Gly Ala 
    130                 135                 140                 


Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys 
145                 150                 155                 160 


Pro Ala Ala Ala Ala Gly Ala Lys Lys Ala Lys Ser Pro Lys Lys Ala 
                165                 170                 175     


Lys Ala Ala Lys Pro Lys Lys Ala Pro Lys Ser Pro Ala Lys Ala Lys 
            180                 185                 190         


Ala Val Lys Pro Lys Ala Ala Lys Pro Lys Thr Ala Lys Pro Lys Ala 
        195                 200                 205             


Ala Lys Pro Lys Lys Ala Ala Ala Lys Lys Lys 
    210                 215                 


<210>  5000
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H1T__Homo_sapiens__NP_005314

<400>  5000

Met Ser Glu Thr Val Pro Ala Ala Ser Ala Ser Ala Gly Val Ala Ala 
1               5                   10                  15      


Met Glu Lys Leu Pro Thr Lys Lys Arg Gly Arg Lys Pro Ala Gly Leu 
            20                  25                  30          


Ile Ser Ala Ser Arg Lys Val Pro Asn Leu Ser Val Ser Lys Leu Ile 
        35                  40                  45              


Thr Glu Ala Leu Ser Val Ser Gln Glu Arg Val Gly Met Ser Leu Val 
    50                  55                  60                  


Ala Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn 
65                  70                  75                  80  


Asn Ser Arg Ile Lys Leu Ser Leu Lys Ser Leu Val Asn Lys Gly Ile 
                85                  90                  95      


Leu Val Gln Thr Arg Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Ser 
            100                 105                 110         


Lys Lys Val Ile Pro Lys Ser Thr Arg Ser Lys Ala Lys Lys Ser Val 
        115                 120                 125             


Ser Ala Lys Thr Lys Lys Leu Val Leu Ser Arg Asp Ser Lys Ser Pro 
    130                 135                 140                 


Lys Thr Ala Lys Thr Asn Lys Arg Ala Lys Lys Pro Arg Ala Thr Thr 
145                 150                 155                 160 


Pro Lys Thr Val Arg Ser Gly Arg Lys Ala Lys Gly Ala Lys Gly Lys 
                165                 170                 175     


Gln Gln Gln Lys Ser Pro Val Lys Ala Arg Ala Ser Lys Ser Lys Leu 
            180                 185                 190         


Thr Gln His His Glu Val Asn Val Arg Lys Ala Thr Ser Lys Lys 
        195                 200                 205         


<210>  5001
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H2AE__Homo_sapiens__NP_066390

<400>  5001

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ser Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Arg Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


Gly Lys 
    130 


<210>  5002
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H2AH__Homo_sapiens__NP_542163

<400>  5002

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


<210>  5003
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H2BG__Homo_sapiens__NP_003509

<400>  5003

Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  5004
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H2BH__Homo_sapiens__NP_003515

<400>  5004

Met Pro Asp Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  5005
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H2BM__Homo_sapiens__NP_003512

<400>  5005

Met Pro Glu Pro Val Lys Ser Ala Pro Val Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Ile Asn Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  5006
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H3G__Homo_sapiens__NP_003525

<400>  5006

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  5007
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST1H4D__Homo_sapiens__NP_003530

<400>  5007

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  5008
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIST3H3__Homo_sapiens__NP_003484

<400>  5008

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Val Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Met Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ser Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Val 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  5009
<211>  2718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIVEP1__Homo_sapiens__XP_011512855

<400>  5009

Met Pro Arg Thr Lys Gln Ile His Pro Arg Asn Leu Arg Asp Lys Ile 
1               5                   10                  15      


Glu Glu Ala Gln Lys Glu Leu Asn Gly Ala Glu Val Ser Lys Lys Glu 
            20                  25                  30          


Ile Leu Gln Ala Gly Val Lys Gly Thr Ser Glu Ser Leu Lys Gly Val 
        35                  40                  45              


Lys Arg Lys Lys Ile Val Ala Glu Asn His Leu Lys Lys Ile Pro Lys 
    50                  55                  60                  


Ser Pro Leu Arg Asn Pro Leu Gln Ala Lys His Lys Gln Asn Thr Glu 
65                  70                  75                  80  


Glu Ser Ser Phe Ala Val Leu His Ser Ala Ser Glu Ser His Lys Lys 
                85                  90                  95      


Gln Asn Tyr Ile Pro Val Lys Asn Gly Lys Gln Phe Thr Lys Gln Asn 
            100                 105                 110         


Gly Glu Thr Pro Gly Ile Ile Ala Glu Ala Ser Lys Ser Glu Glu Ser 
        115                 120                 125             


Val Ser Pro Lys Lys Pro Leu Phe Leu Gln Gln Pro Ser Glu Leu Arg 
    130                 135                 140                 


Arg Trp Arg Ser Glu Gly Ala Asp Pro Ala Lys Phe Ser Asp Leu Asp 
145                 150                 155                 160 


Glu Gln Cys Asp Ser Ser Ser Leu Ser Ser Lys Thr Arg Thr Asp Asn 
                165                 170                 175     


Ser Glu Cys Ile Ser Ser His Cys Gly Thr Thr Ser Pro Ser Tyr Thr 
            180                 185                 190         


Asn Thr Ala Phe Asp Val Leu Leu Lys Ala Met Glu Pro Glu Leu Ser 
        195                 200                 205             


Thr Leu Ser Gln Lys Gly Ser Pro Cys Ala Ile Lys Thr Glu Lys Leu 
    210                 215                 220                 


Arg Pro Asn Lys Thr Ala Arg Ser Pro Pro Lys Leu Lys Asn Ser Ser 
225                 230                 235                 240 


Met Asp Ala Pro Asn Gln Thr Ser Gln Glu Leu Val Ala Glu Ser Gln 
                245                 250                 255     


Ser Ser Cys Thr Ser Tyr Thr Val His Met Ser Ala Ala Gln Lys Asn 
            260                 265                 270         


Glu Gln Gly Ala Met Gln Ser Ala Ser His Leu Tyr His Gln His Glu 
        275                 280                 285             


His Phe Val Pro Lys Ser Asn Gln His Asn Gln Gln Leu Pro Gly Cys 
    290                 295                 300                 


Ser Gly Phe Thr Gly Ser Leu Thr Asn Leu Gln Asn Gln Glu Asn Ala 
305                 310                 315                 320 


Lys Leu Glu Gln Val Tyr Asn Ile Ala Val Thr Ser Ser Val Gly Leu 
                325                 330                 335     


Thr Ser Pro Ser Ser Arg Ser Gln Val Thr Pro Gln Asn Gln Gln Met 
            340                 345                 350         


Asp Ser Ala Ser Pro Leu Ser Ile Ser Pro Ala Asn Ser Thr Gln Ser 
        355                 360                 365             


Pro Pro Met Pro Ile Tyr Asn Ser Thr His Val Ala Ser Val Val Asn 
    370                 375                 380                 


Gln Ser Val Glu Gln Met Cys Asn Leu Leu Leu Lys Asp Gln Lys Pro 
385                 390                 395                 400 


Lys Lys Gln Gly Lys Tyr Ile Cys Glu Tyr Cys Asn Arg Ala Cys Ala 
                405                 410                 415     


Lys Pro Ser Val Leu Leu Lys His Ile Arg Ser His Thr Gly Glu Arg 
            420                 425                 430         


Pro Tyr Pro Cys Val Thr Cys Gly Phe Ser Phe Lys Thr Lys Ser Asn 
        435                 440                 445             


Leu Tyr Lys His Lys Lys Ser His Ala His Thr Ile Lys Leu Gly Leu 
    450                 455                 460                 


Val Leu Gln Pro Asp Ala Gly Gly Leu Phe Leu Ser His Glu Ser Pro 
465                 470                 475                 480 


Lys Ala Leu Ser Ile His Ser Asp Val Glu Asp Ser Gly Glu Ser Glu 
                485                 490                 495     


Glu Glu Gly Ala Thr Asp Glu Arg Gln His Asp Leu Gly Ala Met Glu 
            500                 505                 510         


Leu Gln Pro Val His Ile Ile Lys Arg Met Ser Asn Ala Glu Thr Leu 
        515                 520                 525             


Leu Lys Ser Ser Phe Thr Pro Ser Ser Pro Glu Asn Val Ile Gly Asp 
    530                 535                 540                 


Phe Leu Leu Gln Asp Arg Ser Ala Glu Ser Gln Ala Val Thr Glu Leu 
545                 550                 555                 560 


Pro Lys Val Val Val His His Val Thr Val Ser Pro Leu Arg Thr Asp 
                565                 570                 575     


Ser Pro Lys Ala Met Asp Pro Lys Pro Glu Leu Ser Ser Ala Gln Lys 
            580                 585                 590         


Gln Lys Asp Leu Gln Val Thr Asn Val Gln Pro Leu Ser Ala Asn Met 
        595                 600                 605             


Ser Gln Gly Gly Val Ser Arg Leu Glu Thr Asn Glu Asn Ser His Gln 
    610                 615                 620                 


Lys Gly Asp Met Asn Pro Leu Glu Gly Lys Gln Asp Ser His Val Gly 
625                 630                 635                 640 


Thr Val His Ala Gln Leu Gln Arg Gln Gln Ala Thr Asp Tyr Ser Gln 
                645                 650                 655     


Glu Gln Gln Gly Lys Leu Leu Ser Pro Arg Ser Leu Gly Ser Thr Asp 
            660                 665                 670         


Ser Gly Tyr Phe Ser Arg Ser Glu Ser Ala Asp Gln Thr Val Ser Pro 
        675                 680                 685             


Pro Thr Pro Phe Ala Arg Arg Leu Pro Ser Thr Glu Gln Asp Ser Gly 
    690                 695                 700                 


Arg Ser Asn Gly Pro Ser Ala Ala Leu Val Thr Thr Ser Thr Pro Ser 
705                 710                 715                 720 


Ala Leu Pro Thr Gly Glu Lys Ala Leu Leu Leu Pro Gly Gln Met Arg 
                725                 730                 735     


Pro Pro Leu Ala Thr Lys Thr Leu Glu Glu Arg Ile Ser Lys Leu Ile 
            740                 745                 750         


Ser Asp Asn Glu Ala Leu Val Asp Asp Lys Gln Leu Asp Ser Val Lys 
        755                 760                 765             


Pro Arg Arg Thr Ser Leu Ser Arg Arg Gly Ser Ile Asp Ser Pro Lys 
    770                 775                 780                 


Ser Tyr Ile Phe Lys Asp Ser Phe Gln Phe Asp Leu Lys Pro Val Gly 
785                 790                 795                 800 


Arg Arg Thr Ser Ser Ser Ser Asp Ile Pro Lys Ser Pro Phe Thr Pro 
                805                 810                 815     


Thr Glu Lys Ser Lys Gln Val Phe Leu Leu Ser Val Pro Ser Leu Asp 
            820                 825                 830         


Cys Leu Pro Ile Thr Arg Ser Asn Ser Met Pro Thr Thr Gly Tyr Ser 
        835                 840                 845             


Ala Val Pro Ala Asn Ile Ile Pro Pro Pro His Pro Leu Arg Gly Ser 
    850                 855                 860                 


Gln Ser Phe Asp Asp Lys Ile Gly Ala Phe Tyr Asp Asp Val Phe Val 
865                 870                 875                 880 


Ser Gly Pro Asn Ala Pro Val Pro Gln Ser Gly His Pro Arg Thr Leu 
                885                 890                 895     


Val Arg Gln Ala Ala Ile Glu Asp Ser Ser Ala Asn Glu Ser His Val 
            900                 905                 910         


Leu Gly Thr Gly Gln Ser Leu Asp Glu Ser His Gln Gly Cys His Ala 
        915                 920                 925             


Ala Gly Glu Ala Met Ser Val Arg Ser Lys Ala Leu Ala Gln Gly Pro 
    930                 935                 940                 


His Ile Glu Lys Lys Lys Ser His Gln Gly Arg Gly Thr Met Phe Glu 
945                 950                 955                 960 


Cys Glu Thr Cys Arg Asn Arg Tyr Arg Lys Leu Glu Asn Phe Glu Asn 
                965                 970                 975     


His Lys Lys Phe Tyr Cys Ser Glu Leu His Gly Pro Lys Thr Lys Val 
            980                 985                 990         


Ala Met Arg Glu Pro Glu His Ser  Pro Val Pro Gly Gly  Leu Gln Pro 
        995                 1000                 1005             


Gln Ile  Leu His Tyr Arg Val  Ala Gly Ser Ser Gly  Ile Trp Glu 
    1010                 1015                 1020             


Gln Thr  Pro Gln Ile Arg Lys  Arg Arg Lys Met Lys  Ser Val Gly 
    1025                 1030                 1035             


Asp Asp  Glu Glu Leu Gln Gln  Asn Glu Ser Gly Thr  Ser Pro Lys 
    1040                 1045                 1050             


Ser Ser  Glu Gly Leu Gln Phe  Gln Asn Ala Leu Gly  Cys Asn Pro 
    1055                 1060                 1065             


Ser Leu  Pro Lys His Asn Val  Thr Ile Arg Ser Asp  Gln Gln His 
    1070                 1075                 1080             


Lys Asn  Ile Gln Leu Gln Asn  Ser His Ile His Leu  Val Ala Arg 
    1085                 1090                 1095             


Gly Pro  Glu Gln Thr Met Asp  Pro Lys Leu Ser Thr  Ile Met Glu 
    1100                 1105                 1110             


Gln Gln  Ile Ser Ser Ala Ala  Gln Asp Lys Ile Glu  Leu Gln Arg 
    1115                 1120                 1125             


His Gly  Thr Gly Ile Ser Val  Ile Gln His Thr Asn  Ser Leu Ser 
    1130                 1135                 1140             


Arg Pro  Asn Ser Phe Asp Lys  Pro Glu Pro Phe Glu  Arg Ala Ser 
    1145                 1150                 1155             


Pro Val  Ser Phe Gln Glu Leu  Asn Arg Thr Gly Lys  Ser Gly Ser 
    1160                 1165                 1170             


Leu Lys  Val Ile Gly Ile Ser  Gln Glu Glu Ser His  Pro Ser Arg 
    1175                 1180                 1185             


Asp Gly  Ser His Pro His Gln  Leu Ala Leu Ser Asp  Ala Leu Arg 
    1190                 1195                 1200             


Gly Glu  Leu Gln Glu Ser Ser  Arg Lys Ser Pro Ser  Glu Arg His 
    1205                 1210                 1215             


Val Leu  Gly Gln Pro Ser Arg  Leu Val Arg Gln His  Asn Ile Gln 
    1220                 1225                 1230             


Val Pro  Glu Ile Leu Val Thr  Glu Glu Pro Asp Arg  Asp Leu Glu 
    1235                 1240                 1245             


Ala Gln  Cys His Asp Gln Glu  Lys Ser Glu Lys Phe  Ser Trp Pro 
    1250                 1255                 1260             


Gln Arg  Ser Glu Thr Leu Ser  Lys Leu Pro Thr Glu  Lys Leu Pro 
    1265                 1270                 1275             


Pro Lys  Lys Lys Arg Leu Arg  Leu Ala Glu Ile Glu  His Ser Ser 
    1280                 1285                 1290             


Thr Glu  Ser Ser Phe Asp Ser  Thr Leu Ser Arg Ser  Leu Ser Arg 
    1295                 1300                 1305             


Glu Ser  Ser Leu Ser His Thr  Ser Ser Phe Ser Ala  Ser Leu Asp 
    1310                 1315                 1320             


Ile Glu  Asp Val Ser Lys Thr  Glu Ala Ser Pro Lys  Ile Asp Phe 
    1325                 1330                 1335             


Leu Asn  Lys Ala Glu Phe Leu  Met Ile Pro Ala Gly  Leu Asn Thr 
    1340                 1345                 1350             


Leu Asn  Val Pro Gly Cys His  Arg Glu Met Arg Arg  Thr Ala Ser 
    1355                 1360                 1365             


Glu Gln  Ile Asn Cys Thr Gln  Thr Ser Met Glu Val  Ser Asp Leu 
    1370                 1375                 1380             


Arg Ser  Lys Ser Phe Asp Cys  Gly Ser Ile Thr Pro  Pro Gln Thr 
    1385                 1390                 1395             


Thr Pro  Leu Thr Glu Leu Gln  Pro Pro Ser Ser Pro  Ser Arg Val 
    1400                 1405                 1410             


Gly Val  Thr Gly His Val Pro  Leu Leu Glu Arg Arg  Arg Gly Pro 
    1415                 1420                 1425             


Leu Val  Arg Gln Ile Ser Leu  Asn Ile Ala Pro Asp  Ser His Leu 
    1430                 1435                 1440             


Ser Pro  Val His Pro Thr Ser  Phe Gln Asn Thr Ala  Leu Pro Ser 
    1445                 1450                 1455             


Val Asn  Ala Val Pro Tyr Gln  Gly Pro Gln Leu Thr  Ser Thr Ser 
    1460                 1465                 1470             


Leu Ala  Glu Phe Ser Ala Asn  Thr Leu His Ser Gln  Thr Gln Val 
    1475                 1480                 1485             


Lys Asp  Leu Gln Ala Glu Thr  Ser Asn Ser Ser Ser  Thr Asn Val 
    1490                 1495                 1500             


Phe Pro  Val Gln Gln Leu Cys  Asp Ile Asn Leu Leu  Asn Gln Ile 
    1505                 1510                 1515             


His Ala  Pro Pro Ser His Gln  Ser Thr Gln Leu Ser  Leu Gln Val 
    1520                 1525                 1530             


Ser Thr  Gln Gly Ser Lys Pro  Asp Lys Asn Ser Val  Leu Ser Gly 
    1535                 1540                 1545             


Ser Ser  Lys Ser Glu Asp Cys  Phe Ala Pro Lys Tyr  Gln Leu His 
    1550                 1555                 1560             


Cys Gln  Val Phe Thr Ser Gly  Pro Ser Cys Ser Ser  Asn Pro Val 
    1565                 1570                 1575             


His Ser  Leu Pro Asn Gln Val  Ile Ser Asp Pro Val  Gly Thr Asp 
    1580                 1585                 1590             


His Cys  Val Thr Ser Ala Thr  Leu Pro Thr Lys Leu  Ile Asp Ser 
    1595                 1600                 1605             


Met Ser  Asn Ser His Pro Leu  Leu Pro Pro Glu Leu  Arg Pro Leu 
    1610                 1615                 1620             


Gly Ser  Gln Val Gln Lys Val  Pro Ser Ser Phe Met  Leu Pro Ile 
    1625                 1630                 1635             


Arg Leu  Gln Ser Ser Val Pro  Ala Tyr Cys Phe Ala  Thr Leu Thr 
    1640                 1645                 1650             


Ser Leu  Pro Gln Ile Leu Val  Thr Gln Asp Leu Pro  Asn Gln Pro 
    1655                 1660                 1665             


Ile Cys  Gln Thr Asn His Ser  Val Val Pro Ile Ser  Glu Glu Gln 
    1670                 1675                 1680             


Asn Ser  Val Pro Thr Leu Gln  Lys Gly His Gln Asn  Ala Leu Pro 
    1685                 1690                 1695             


Asn Pro  Glu Lys Glu Phe Leu  Cys Glu Asn Val Phe  Ser Glu Met 
    1700                 1705                 1710             


Ser Gln  Asn Ser Ser Leu Ser  Glu Ser Leu Pro Ile  Thr Gln Lys 
    1715                 1720                 1725             


Ile Ser  Val Gly Arg Leu Ser  Pro Gln Gln Glu Ser  Ser Ala Ser 
    1730                 1735                 1740             


Ser Lys  Arg Met Leu Ser Pro  Ala Asn Ser Leu Asp  Ile Ala Met 
    1745                 1750                 1755             


Glu Lys  His Gln Lys Arg Ala  Lys Asp Glu Asn Gly  Ala Val Cys 
    1760                 1765                 1770             


Ala Thr  Asp Val Arg Pro Leu  Glu Ala Leu Ser Ser  Arg Val Asn 
    1775                 1780                 1785             


Glu Ala  Ser Lys Gln Lys Lys  Pro Ile Leu Val Arg  Gln Val Cys 
    1790                 1795                 1800             


Thr Thr  Glu Pro Leu Asp Gly  Val Met Leu Glu Lys  Asp Val Phe 
    1805                 1810                 1815             


Ser Gln  Pro Glu Ile Ser Asn  Glu Ala Val Asn Leu  Thr Asn Val 
    1820                 1825                 1830             


Leu Pro  Ala Asp Asn Ser Ser  Thr Gly Cys Ser Lys  Phe Val Val 
    1835                 1840                 1845             


Ile Glu  Pro Ile Ser Glu Leu  Gln Glu Phe Glu Asn  Ile Lys Ser 
    1850                 1855                 1860             


Ser Thr  Ser Leu Thr Leu Thr  Val Arg Ser Ser Pro  Ala Pro Ser 
    1865                 1870                 1875             


Glu Asn  Thr His Ile Ser Pro  Leu Lys Cys Thr Asp  Asn Asn Gln 
    1880                 1885                 1890             


Glu Arg  Lys Ser Pro Gly Val  Lys Asn Gln Gly Asp  Lys Val Asn 
    1895                 1900                 1905             


Ile Gln  Glu Gln Ser Gln Gln  Pro Val Thr Ser Leu  Ser Leu Phe 
    1910                 1915                 1920             


Asn Ile  Lys Asp Thr Gln Gln  Leu Ala Phe Pro Ser  Leu Lys Thr 
    1925                 1930                 1935             


Thr Thr  Asn Phe Thr Trp Cys  Tyr Leu Leu Arg Gln  Lys Ser Leu 
    1940                 1945                 1950             


His Leu  Pro Gln Lys Asp Gln  Lys Thr Ser Ala Tyr  Thr Asp Trp 
    1955                 1960                 1965             


Thr Val  Ser Ala Ser Asn Pro  Asn Pro Leu Gly Leu  Pro Thr Lys 
    1970                 1975                 1980             


Val Ala  Leu Ala Leu Leu Asn  Ser Lys Gln Asn Thr  Gly Lys Ser 
    1985                 1990                 1995             


Leu Tyr  Cys Gln Ala Ile Thr  Thr His Ser Lys Ser  Asp Leu Leu 
    2000                 2005                 2010             


Val Tyr  Ser Ser Lys Trp Lys  Ser Ser Leu Ser Lys  Arg Ala Leu 
    2015                 2020                 2025             


Gly Asn  Gln Lys Ser Thr Val  Val Glu Phe Ser Asn  Lys Asp Ala 
    2030                 2035                 2040             


Ser Glu  Ile Asn Ser Glu Gln  Asp Lys Glu Asn Ser  Leu Ile Lys 
    2045                 2050                 2055             


Ser Glu  Pro Arg Arg Ile Lys  Ile Phe Asp Gly Gly  Tyr Lys Ser 
    2060                 2065                 2070             


Asn Glu  Glu Tyr Val Tyr Val  Arg Gly Arg Gly Arg  Gly Lys Tyr 
    2075                 2080                 2085             


Ile Cys  Glu Glu Cys Gly Ile  Arg Cys Lys Lys Pro  Ser Met Leu 
    2090                 2095                 2100             


Lys Lys  His Ile Arg Thr His  Thr Asp Val Arg Pro  Tyr His Cys 
    2105                 2110                 2115             


Thr Tyr  Cys Asn Phe Ser Phe  Lys Thr Lys Gly Asn  Leu Thr Lys 
    2120                 2125                 2130             


His Met  Lys Ser Lys Ala His  Ser Lys Lys Cys Val  Asp Leu Gly 
    2135                 2140                 2145             


Val Ser  Val Gly Leu Ile Asp  Glu Gln Asp Thr Glu  Glu Ser Asp 
    2150                 2155                 2160             


Glu Lys  Gln Arg Phe Ser Tyr  Glu Arg Ser Gly Tyr  Asp Leu Glu 
    2165                 2170                 2175             


Glu Ser  Asp Gly Pro Asp Glu  Asp Asp Asn Glu Asn  Glu Asp Asp 
    2180                 2185                 2190             


Asp Glu  Asp Ser Gln Ala Glu  Ser Val Leu Ser Ala  Thr Pro Ser 
    2195                 2200                 2205             


Val Thr  Ala Ser Pro Gln His  Leu Pro Ser Arg Ser  Ser Leu Gln 
    2210                 2215                 2220             


Asp Pro  Val Ser Thr Asp Glu  Asp Val Arg Ile Thr  Asp Cys Phe 
    2225                 2230                 2235             


Ser Gly  Val His Thr Asp Pro  Met Asp Val Leu Pro  Arg Ala Leu 
    2240                 2245                 2250             


Leu Thr  Arg Met Thr Val Leu  Ser Thr Ala Gln Ser  Asp Tyr Asn 
    2255                 2260                 2265             


Arg Lys  Thr Leu Ser Pro Gly  Lys Ala Arg Gln Arg  Ala Ala Arg 
    2270                 2275                 2280             


Asp Glu  Asn Asp Thr Ile Pro  Ser Val Asp Thr Ser  Arg Ser Pro 
    2285                 2290                 2295             


Cys His  Gln Met Ser Val Asp  Tyr Pro Glu Ser Glu  Glu Ile Leu 
    2300                 2305                 2310             


Arg Ser  Ser Met Ala Gly Lys  Ala Val Ala Ile Thr  Gln Ser Pro 
    2315                 2320                 2325             


Ser Ser  Val Arg Leu Pro Pro  Ala Ala Ala Glu His  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ala  Ala Gly Met Pro Ser  Val Ala Ser Pro His  Pro Asp Pro 
    2345                 2350                 2355             


Gln Glu  Gln Lys Gln Gln Ile  Thr Leu Gln Pro Thr  Pro Gly Leu 
    2360                 2365                 2370             


Pro Ser  Pro His Thr His Leu  Phe Ser His Leu Pro  Leu His Ser 
    2375                 2380                 2385             


Gln Gln  Gln Ser Arg Thr Pro  Tyr Asn Met Val Pro  Val Gly Gly 
    2390                 2395                 2400             


Ile His  Val Val Pro Ala Gly  Leu Thr Tyr Ser Thr  Phe Val Pro 
    2405                 2410                 2415             


Leu Gln  Ala Gly Pro Val Gln  Leu Thr Ile Pro Ala  Val Ser Val 
    2420                 2425                 2430             


Val His  Arg Thr Leu Gly Thr  His Arg Asn Thr Val  Thr Glu Val 
    2435                 2440                 2445             


Ser Gly  Thr Thr Asn Pro Ala  Gly Val Ala Glu Leu  Ser Ser Val 
    2450                 2455                 2460             


Val Pro  Cys Ile Pro Ile Gly  Gln Ile Arg Val Pro  Gly Leu Gln 
    2465                 2470                 2475             


Asn Leu  Ser Thr Pro Gly Leu  Gln Ser Leu Pro Ser  Leu Ser Met 
    2480                 2485                 2490             


Glu Thr  Val Asn Ile Val Gly  Leu Ala Asn Thr Asn  Met Ala Pro 
    2495                 2500                 2505             


Gln Val  His Pro Pro Gly Leu  Ala Leu Asn Ala Val  Gly Leu Gln 
    2510                 2515                 2520             


Val Leu  Thr Ala Asn Pro Ser  Ser Gln Ser Ser Pro  Ala Pro Gln 
    2525                 2530                 2535             


Ala His  Ile Pro Gly Leu Gln  Ile Leu Asn Ile Ala  Leu Pro Thr 
    2540                 2545                 2550             


Leu Ile  Pro Ser Val Ser Gln  Val Ala Val Asp Ala  Gln Gly Ala 
    2555                 2560                 2565             


Pro Glu  Met Pro Ala Ser Gln  Ser Lys Ala Cys Glu  Thr Gln Pro 
    2570                 2575                 2580             


Lys Gln  Thr Ser Val Ala Ser  Ala Asn Gln Val Ser  Arg Thr Glu 
    2585                 2590                 2595             


Ser Pro  Gln Gly Leu Pro Thr  Val Gln Arg Glu Asn  Ala Lys Lys 
    2600                 2605                 2610             


Val Leu  Asn Pro Pro Ala Pro  Ala Gly Asp His Ala  Arg Leu Asp 
    2615                 2620                 2625             


Gly Leu  Ser Lys Met Asp Thr  Glu Lys Ala Ala Ser  Ala Asn His 
    2630                 2635                 2640             


Val Lys  Pro Lys Pro Glu Leu  Thr Ser Ile Gln Gly  Gln Pro Ala 
    2645                 2650                 2655             


Ser Thr  Ser Gln Pro Leu Leu  Lys Ala His Ser Glu  Val Phe Thr 
    2660                 2665                 2670             


Lys Pro  Ser Gly Gln Gln Thr  Leu Ser Pro Asp Arg  Gln Val Pro 
    2675                 2680                 2685             


Arg Pro  Thr Ala Leu Pro Arg  Arg Gln Pro Thr Val  His Phe Ser 
    2690                 2695                 2700             


Asp Val  Ser Ser Asp Asp Asp  Glu Asp Arg Leu Val  Ile Ala Thr 
    2705                 2710                 2715             


<210>  5010
<211>  2446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIVEP2__Homo_sapiens__NP_006725

<400>  5010

Met Asp Thr Gly Asp Thr Ala Leu Gly Gln Lys Ala Thr Ser Arg Ser 
1               5                   10                  15      


Gly Glu Thr Asp Lys Ala Ser Gly Arg Trp Arg Gln Glu Gln Ser Ala 
            20                  25                  30          


Val Ile Lys Met Ser Thr Phe Gly Ser His Glu Gly Gln Arg Gln Pro 
        35                  40                  45              


Gln Ile Glu Pro Glu Gln Ile Gly Asn Thr Ala Ser Ala Gln Leu Phe 
    50                  55                  60                  


Gly Ser Gly Lys Leu Ala Ser Pro Ser Glu Val Val Gln Gln Val Ala 
65                  70                  75                  80  


Glu Lys Gln Tyr Pro Pro His Arg Pro Ser Pro Tyr Ser Cys Gln His 
                85                  90                  95      


Ser Leu Ser Phe Pro Gln His Ser Leu Pro Gln Gly Val Met His Ser 
            100                 105                 110         


Thr Lys Pro His Gln Ser Leu Glu Gly Pro Pro Trp Leu Phe Pro Gly 
        115                 120                 125             


Pro Leu Pro Ser Val Ala Ser Glu Asp Leu Phe Pro Phe Pro Ile His 
    130                 135                 140                 


Gly His Ser Gly Gly Tyr Pro Arg Lys Lys Ile Ser Ser Leu Asn Pro 
145                 150                 155                 160 


Ala Tyr Ser Gln Tyr Ser Gln Lys Ser Ile Glu Gln Ala Glu Glu Ala 
                165                 170                 175     


His Lys Lys Glu His Lys Pro Lys Lys Pro Gly Lys Tyr Ile Cys Pro 
            180                 185                 190         


Tyr Cys Ser Arg Ala Cys Ala Lys Pro Ser Val Leu Lys Lys His Ile 
        195                 200                 205             


Arg Ser His Thr Gly Glu Arg Pro Tyr Pro Cys Ile Pro Cys Gly Phe 
    210                 215                 220                 


Ser Phe Lys Thr Lys Ser Asn Leu Tyr Lys His Arg Lys Ser His Ala 
225                 230                 235                 240 


His Ala Ile Lys Ala Gly Leu Val Pro Phe Thr Glu Ser Ala Val Ser 
                245                 250                 255     


Lys Leu Asp Leu Glu Ala Gly Phe Ile Asp Val Glu Ala Glu Ile His 
            260                 265                 270         


Ser Asp Gly Glu Gln Ser Thr Asp Thr Asp Glu Glu Ser Ser Leu Phe 
        275                 280                 285             


Ala Glu Ala Ser Asp Lys Met Ser Pro Gly Pro Pro Ile Pro Leu Asp 
    290                 295                 300                 


Ile Ala Ser Arg Gly Gly Tyr His Gly Ser Leu Glu Glu Ser Leu Gly 
305                 310                 315                 320 


Gly Pro Met Lys Val Pro Ile Leu Ile Ile Pro Lys Ser Gly Ile Pro 
                325                 330                 335     


Leu Pro Asn Glu Ser Ser Gln Tyr Ile Gly Pro Asp Met Leu Pro Asn 
            340                 345                 350         


Pro Ser Leu Asn Thr Lys Ala Asp Asp Ser His Thr Val Lys Gln Lys 
        355                 360                 365             


Leu Ala Leu Arg Leu Ser Glu Lys Lys Gly Gln Asp Ser Glu Pro Ser 
    370                 375                 380                 


Leu Asn Leu Leu Ser Pro His Ser Lys Gly Ser Thr Asp Ser Gly Tyr 
385                 390                 395                 400 


Phe Ser Arg Ser Glu Ser Ala Glu Gln Gln Ile Ser Pro Pro Asn Thr 
                405                 410                 415     


Asn Ala Lys Ser Tyr Glu Glu Ile Ile Phe Gly Lys Tyr Cys Arg Leu 
            420                 425                 430         


Ser Pro Arg Asn Ala Leu Ser Val Thr Thr Thr Ser Gln Glu Arg Ala 
        435                 440                 445             


Ala Met Gly Arg Lys Gly Ile Met Glu Pro Leu Pro His Val Asn Thr 
    450                 455                 460                 


Arg Leu Asp Val Lys Met Phe Glu Asp Pro Val Ser Gln Leu Ile Pro 
465                 470                 475                 480 


Ser Lys Gly Asp Val Asp Pro Ser Gln Thr Ser Met Leu Lys Ser Thr 
                485                 490                 495     


Lys Phe Asn Ser Glu Ser Arg Gln Pro Gln Ile Ile Pro Ser Ser Ile 
            500                 505                 510         


Arg Asn Glu Gly Lys Leu Tyr Pro Ala Asn Phe Gln Gly Ser Asn Pro 
        515                 520                 525             


Val Leu Leu Glu Ala Pro Val Asp Ser Ser Pro Leu Ile Arg Ser Asn 
    530                 535                 540                 


Ser Val Pro Thr Ser Ser Ala Thr Asn Leu Thr Ile Pro Pro Ser Leu 
545                 550                 555                 560 


Arg Gly Ser His Ser Phe Asp Glu Arg Met Thr Gly Ser Asp Asp Val 
                565                 570                 575     


Phe Tyr Pro Gly Thr Val Gly Ile Pro Pro Gln Arg Met Leu Arg Arg 
            580                 585                 590         


Gln Ala Ala Phe Glu Leu Pro Ser Val Gln Glu Gly His Val Glu Val 
        595                 600                 605             


Glu His His Gly Arg Met Leu Lys Gly Ile Ser Ser Ser Ser Leu Lys 
    610                 615                 620                 


Glu Lys Lys Leu Ser Pro Gly Asp Arg Val Gly Tyr Asp Tyr Asp Val 
625                 630                 635                 640 


Cys Arg Lys Pro Tyr Lys Lys Trp Glu Asp Ser Glu Thr Pro Lys Gln 
                645                 650                 655     


Asn Tyr Arg Asp Ile Ser Cys Leu Ser Ser Leu Lys His Gly Gly Glu 
            660                 665                 670         


Tyr Phe Met Asp Pro Val Val Pro Leu Gln Gly Val Pro Ser Met Phe 
        675                 680                 685             


Gly Thr Thr Cys Glu Asn Arg Lys Arg Arg Lys Glu Lys Ser Val Gly 
    690                 695                 700                 


Asp Glu Glu Asp Thr Pro Met Ile Cys Ser Ser Ile Val Ser Thr Pro 
705                 710                 715                 720 


Val Gly Ile Met Ala Ser Asp Tyr Asp Pro Lys Leu Gln Met Gln Glu 
                725                 730                 735     


Gly Val Arg Ser Gly Phe Ala Met Ala Gly His Glu Asn Leu Ser His 
            740                 745                 750         


Gly His Thr Glu Arg Phe Asp Pro Cys Arg Pro Gln Leu Gln Pro Gly 
        755                 760                 765             


Ser Pro Ser Leu Val Ser Glu Glu Ser Pro Ser Ala Ile Asp Ser Asp 
    770                 775                 780                 


Lys Met Ser Asp Leu Gly Gly Arg Lys Pro Pro Gly Asn Val Ile Ser 
785                 790                 795                 800 


Val Ile Gln His Thr Asn Ser Leu Ser Arg Pro Asn Ser Phe Glu Arg 
                805                 810                 815     


Ser Glu Ser Ala Glu Leu Val Ala Cys Thr Gln Asp Lys Ala Pro Ser 
            820                 825                 830         


Pro Ser Glu Thr Cys Asp Ser Glu Ile Ser Glu Ala Pro Val Ser Pro 
        835                 840                 845             


Glu Trp Ala Pro Pro Gly Asp Gly Ala Glu Ser Gly Gly Lys Pro Ser 
    850                 855                 860                 


Pro Ser Gln Gln Val Gln Gln Gln Ser Tyr His Thr Gln Pro Arg Leu 
865                 870                 875                 880 


Val Arg Gln His Asn Ile Gln Val Pro Glu Ile Arg Val Thr Glu Glu 
                885                 890                 895     


Pro Asp Lys Pro Glu Lys Glu Lys Glu Ala Gln Ser Lys Glu Pro Glu 
            900                 905                 910         


Lys Pro Val Glu Glu Phe Gln Trp Pro Gln Arg Ser Glu Thr Leu Ser 
        915                 920                 925             


Gln Leu Pro Ala Glu Lys Leu Pro Pro Lys Lys Lys Arg Leu Arg Leu 
    930                 935                 940                 


Ala Asp Met Glu His Ser Ser Gly Glu Ser Ser Phe Glu Ser Thr Gly 
945                 950                 955                 960 


Thr Gly Leu Ser Arg Ser Pro Ser Gln Glu Ser Asn Leu Ser His Ser 
                965                 970                 975     


Ser Ser Phe Ser Met Ser Phe Glu Arg Glu Glu Thr Ser Lys Leu Ser 
            980                 985                 990         


Ala Leu Pro Lys Gln Asp Glu Phe  Gly Lys His Ser Glu  Phe Leu Thr 
        995                 1000                 1005             


Val Pro  Ala Gly Ser Tyr Ser  Leu Ser Val Pro Gly  His His His 
    1010                 1015                 1020             


Gln Lys  Glu Met Arg Arg Cys  Ser Ser Glu Gln Met  Pro Cys Pro 
    1025                 1030                 1035             


His Pro  Ala Glu Val Pro Glu  Val Arg Ser Lys Ser  Phe Asp Tyr 
    1040                 1045                 1050             


Gly Asn  Leu Ser His Ala Pro  Val Ser Gly Ala Ala  Ala Ser Thr 
    1055                 1060                 1065             


Val Ser  Pro Ser Arg Glu Arg  Lys Lys Cys Phe Leu  Val Arg Gln 
    1070                 1075                 1080             


Ala Ser  Phe Ser Gly Ser Pro  Glu Ile Ser Gln Gly  Glu Val Gly 
    1085                 1090                 1095             


Met Asp  Gln Ser Val Lys Gln  Glu Gln Leu Glu His  Leu His Ala 
    1100                 1105                 1110             


Gly Leu  Arg Ser Gly Trp His  His Gly Pro Pro Ala  Val Leu Pro 
    1115                 1120                 1125             


Pro Leu  Gln Gln Glu Asp Pro  Gly Lys Gln Val Ala  Gly Pro Cys 
    1130                 1135                 1140             


Pro Pro  Leu Ser Ser Gly Pro  Leu His Leu Ala Gln  Pro Gln Ile 
    1145                 1150                 1155             


Met His  Met Asp Ser Gln Glu  Ser Leu Arg Asn Pro  Leu Ile Gln 
    1160                 1165                 1170             


Pro Thr  Ser Tyr Met Thr Ser  Lys His Leu Pro Glu  Gln Pro His 
    1175                 1180                 1185             


Leu Phe  Pro His Gln Glu Thr  Ile Pro Phe Ser Pro  Ile Gln Asn 
    1190                 1195                 1200             


Ala Leu  Phe Gln Phe Gln Tyr  Pro Thr Val Cys Met  Val His Leu 
    1205                 1210                 1215             


Pro Ala  Gln Gln Pro Pro Trp  Trp Gln Ala His Phe  Pro His Pro 
    1220                 1225                 1230             


Phe Ala  Gln His Pro Gln Lys  Ser Tyr Gly Lys Pro  Ser Phe Gln 
    1235                 1240                 1245             


Thr Glu  Ile His Ser Ser Tyr  Pro Leu Glu His Val  Ala Glu His 
    1250                 1255                 1260             


Thr Gly  Lys Lys Pro Ala Glu  Tyr Ala His Thr Lys  Glu Gln Thr 
    1265                 1270                 1275             


Tyr Pro  Cys Tyr Ser Gly Ala  Ser Gly Leu His Pro  Lys Asn Leu 
    1280                 1285                 1290             


Leu Pro  Lys Phe Pro Ser Asp  Gln Ser Ser Lys Ser  Thr Glu Thr 
    1295                 1300                 1305             


Pro Ser  Glu Gln Val Leu Gln  Glu Asp Phe Ala Ser  Ala Asn Ala 
    1310                 1315                 1320             


Gly Ser  Leu Gln Ser Leu Pro  Gly Thr Val Val Pro  Val Arg Ile 
    1325                 1330                 1335             


Gln Thr  His Val Pro Ser Tyr  Gly Ser Val Met Tyr  Thr Ser Ile 
    1340                 1345                 1350             


Ser Gln  Ile Leu Gly Gln Asn  Ser Pro Ala Ile Val  Ile Cys Lys 
    1355                 1360                 1365             


Val Asp  Glu Asn Met Thr Gln  Arg Thr Leu Val Thr  Asn Ala Ala 
    1370                 1375                 1380             


Met Gln  Gly Ile Gly Phe Asn  Ile Ala Gln Val Leu  Gly Gln His 
    1385                 1390                 1395             


Ala Gly  Leu Glu Lys Tyr Pro  Ile Trp Lys Ala Pro  Gln Thr Leu 
    1400                 1405                 1410             


Pro Leu  Gly Leu Glu Ser Ser  Ile Pro Leu Cys Leu  Pro Ser Thr 
    1415                 1420                 1425             


Ser Asp  Ser Val Ala Thr Leu  Gly Gly Ser Lys Arg  Met Leu Ser 
    1430                 1435                 1440             


Pro Ala  Ser Ser Leu Glu Leu  Phe Met Glu Thr Lys  Gln Gln Lys 
    1445                 1450                 1455             


Arg Val  Lys Glu Glu Lys Met  Tyr Gly Gln Ile Val  Glu Glu Leu 
    1460                 1465                 1470             


Ser Ala  Val Glu Leu Thr Asn  Ser Asp Ile Lys Lys  Asp Leu Ser 
    1475                 1480                 1485             


Arg Pro  Gln Lys Pro Gln Leu  Val Arg Gln Gly Cys  Ala Ser Glu 
    1490                 1495                 1500             


Pro Lys  Asp Gly Leu Gln Ser  Gly Ser Ser Ser Phe  Ser Ser Leu 
    1505                 1510                 1515             


Ser Pro  Ser Ser Ser Gln Asp  Tyr Pro Ser Val Ser  Pro Ser Ser 
    1520                 1525                 1530             


Arg Glu  Pro Phe Leu Pro Ser  Lys Glu Met Leu Ser  Gly Ser Arg 
    1535                 1540                 1545             


Ala Pro  Leu Pro Gly Gln Lys  Ser Ser Gly Pro Ser  Glu Ser Lys 
    1550                 1555                 1560             


Glu Ser  Ser Asp Glu Leu Asp  Ile Asp Glu Thr Ala  Ser Asp Met 
    1565                 1570                 1575             


Ser Met  Ser Pro Gln Ser Ser  Ser Leu Pro Ala Gly  Asp Gly Gln 
    1580                 1585                 1590             


Leu Glu  Glu Glu Gly Lys Gly  His Lys Arg Pro Val  Gly Met Leu 
    1595                 1600                 1605             


Val Arg  Met Ala Ser Ala Pro  Ser Gly Asn Val Ala  Asp Ser Thr 
    1610                 1615                 1620             


Leu Leu  Leu Thr Asp Met Ala  Asp Phe Gln Gln Ile  Leu Gln Phe 
    1625                 1630                 1635             


Pro Ser  Leu Arg Thr Thr Thr  Thr Val Ser Trp Cys  Phe Leu Asn 
    1640                 1645                 1650             


Tyr Thr  Lys Pro Asn Tyr Val  Gln Gln Ala Thr Phe  Lys Ser Ser 
    1655                 1660                 1665             


Val Tyr  Ala Ser Trp Cys Ile  Ser Ser Cys Asn Pro  Asn Pro Ser 
    1670                 1675                 1680             


Gly Leu  Asn Thr Lys Thr Thr  Leu Ala Leu Leu Arg  Ser Lys Gln 
    1685                 1690                 1695             


Lys Ile  Thr Ala Glu Ile Tyr  Thr Leu Ala Ala Met  His Arg Pro 
    1700                 1705                 1710             


Gly Thr  Gly Lys Leu Thr Ser  Ser Ser Ala Trp Lys  Gln Phe Thr 
    1715                 1720                 1725             


Gln Met  Lys Pro Asp Ala Ser  Phe Leu Phe Gly Ser  Lys Leu Glu 
    1730                 1735                 1740             


Arg Lys  Leu Val Gly Asn Ile  Leu Lys Glu Arg Gly  Lys Gly Asp 
    1745                 1750                 1755             


Ile His  Gly Asp Lys Asp Ile  Gly Ser Lys Gln Thr  Glu Pro Ile 
    1760                 1765                 1770             


Arg Ile  Lys Ile Phe Glu Gly  Gly Tyr Lys Ser Asn  Glu Asp Tyr 
    1775                 1780                 1785             


Val Tyr  Val Arg Gly Arg Gly  Arg Gly Lys Tyr Ile  Cys Glu Glu 
    1790                 1795                 1800             


Cys Gly  Ile Arg Cys Lys Lys  Pro Ser Met Leu Lys  Lys His Ile 
    1805                 1810                 1815             


Arg Thr  His Thr Asp Val Arg  Pro Tyr Val Cys Lys  Leu Cys Asn 
    1820                 1825                 1830             


Phe Ala  Phe Lys Thr Lys Gly  Asn Leu Thr Lys His  Met Lys Ser 
    1835                 1840                 1845             


Lys Ala  His Met Lys Lys Cys  Leu Glu Leu Gly Val  Ser Met Thr 
    1850                 1855                 1860             


Ser Val  Asp Asp Thr Glu Thr  Glu Glu Ala Glu Asn  Leu Glu Asp 
    1865                 1870                 1875             


Leu His  Lys Ala Ala Glu Lys  His Ser Met Ser Ser  Ile Ser Thr 
    1880                 1885                 1890             


Asp His  Gln Phe Ser Asp Ala  Glu Glu Ser Asp Gly  Glu Asp Gly 
    1895                 1900                 1905             


Asp Asp  Asn Asp Asp Asp Asp  Glu Asp Glu Asp Asp  Phe Asp Asp 
    1910                 1915                 1920             


Gln Gly  Asp Leu Thr Pro Lys  Thr Arg Ser Arg Ser  Thr Ser Pro 
    1925                 1930                 1935             


Gln Pro  Pro Arg Phe Ser Ser  Leu Pro Val Asn Val  Gly Ala Val 
    1940                 1945                 1950             


Pro His  Gly Val Pro Ser Asp  Ser Ser Leu Gly His  Ser Ser Leu 
    1955                 1960                 1965             


Ile Ser  Tyr Leu Val Thr Leu  Pro Ser Ile Arg Val  Thr Gln Leu 
    1970                 1975                 1980             


Met Thr  Pro Ser Asp Ser Cys  Glu Asp Thr Gln Met  Thr Glu Tyr 
    1985                 1990                 1995             


Gln Arg  Leu Phe Gln Ser Lys  Ser Thr Asp Ser Glu  Pro Asp Lys 
    2000                 2005                 2010             


Asp Arg  Leu Asp Ile Pro Ser  Cys Met Asp Glu Glu  Cys Met Leu 
    2015                 2020                 2025             


Pro Ser  Glu Pro Ser Ser Ser  Pro Arg Asp Phe Ser  Pro Ser Ser 
    2030                 2035                 2040             


His His  Ser Ser Pro Gly Tyr  Asp Ser Ser Pro Cys  Arg Asp Asn 
    2045                 2050                 2055             


Ser Pro  Lys Arg Tyr Leu Ile  Pro Lys Gly Asp Leu  Ser Pro Arg 
    2060                 2065                 2070             


Arg His  Leu Ser Pro Arg Arg  Asp Leu Ser Pro Met  Arg His Leu 
    2075                 2080                 2085             


Ser Pro  Arg Lys Glu Ala Ala  Leu Arg Arg Glu Met  Ser Gln Arg 
    2090                 2095                 2100             


Asp Val  Ser Pro Arg Arg His  Leu Ser Pro Arg Arg  Pro Val Ser 
    2105                 2110                 2115             


Pro Gly  Lys Asp Ile Thr Ala  Arg Arg Asp Leu Ser  Pro Arg Arg 
    2120                 2125                 2130             


Glu Arg  Arg Tyr Met Thr Thr  Ile Arg Ala Pro Ser  Pro Arg Arg 
    2135                 2140                 2145             


Ala Leu  Tyr His Asn Pro Pro  Leu Ser Met Gly Gln  Tyr Leu Gln 
    2150                 2155                 2160             


Ala Glu  Pro Ile Val Leu Gly  Pro Pro Asn Leu Arg  Arg Gly Leu 
    2165                 2170                 2175             


Pro Gln  Val Pro Tyr Phe Ser  Leu Tyr Gly Asp Gln  Glu Gly Ala 
    2180                 2185                 2190             


Tyr Glu  His Pro Gly Ser Ser  Leu Phe Pro Glu Gly  Pro Asn Asp 
    2195                 2200                 2205             


Tyr Val  Phe Ser His Leu Pro  Leu His Ser Gln Gln  Gln Val Arg 
    2210                 2215                 2220             


Ala Pro  Ile Pro Met Val Pro  Val Gly Gly Ile Gln  Met Val His 
    2225                 2230                 2235             


Ser Met  Pro Pro Ala Leu Ser  Ser Leu His Pro Ser  Pro Thr Leu 
    2240                 2245                 2250             


Pro Leu  Pro Met Glu Gly Phe  Glu Glu Lys Lys Gly  Ala Ser Gly 
    2255                 2260                 2265             


Glu Ser  Phe Ser Lys Asp Pro  Tyr Val Leu Ser Lys  Gln His Glu 
    2270                 2275                 2280             


Lys Arg  Gly Pro His Ala Leu  Gln Ser Ser Gly Pro  Pro Ser Thr 
    2285                 2290                 2295             


Pro Ser  Ser Pro Arg Leu Leu  Met Lys Gln Ser Thr  Ser Glu Asp 
    2300                 2305                 2310             


Ser Leu  Asn Ala Thr Glu Arg  Glu Gln Glu Glu Asn  Ile Gln Thr 
    2315                 2320                 2325             


Cys Thr  Lys Ala Ile Ala Ser  Leu Arg Ile Ala Thr  Glu Glu Ala 
    2330                 2335                 2340             


Ala Leu  Leu Gly Pro Asp Gln  Pro Ala Arg Val Gln  Glu Pro His 
    2345                 2350                 2355             


Gln Asn  Pro Leu Gly Ser Ala  His Val Ser Ile Arg  His Phe Ser 
    2360                 2365                 2370             


Arg Pro  Glu Pro Gly Gln Pro  Cys Thr Ser Ala Thr  His Pro Asp 
    2375                 2380                 2385             


Leu His  Asp Gly Glu Lys Asp  Asn Phe Gly Thr Ser  Gln Thr Pro 
    2390                 2395                 2400             


Leu Ala  His Ser Thr Phe Tyr  Ser Lys Ser Cys Val  Asp Asp Lys 
    2405                 2410                 2415             


Gln Leu  Asp Phe His Ser Ser  Lys Glu Leu Ser Ser  Ser Thr Glu 
    2420                 2425                 2430             


Glu Ser  Lys Asp Pro Ser Ser  Glu Lys Ser Gln Leu  His 
    2435                 2440                 2445     


<210>  5011
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HJURP__Homo_sapiens__NP_001269891

<400>  5011

Met Leu Gly Thr Leu Arg Ala Met Glu Gly Glu Asp Val Glu Asp Asp 
1               5                   10                  15      


Gln Leu Leu Gln Lys Leu Arg Ala Ser Arg Arg Arg Phe Gln Arg Arg 
            20                  25                  30          


Met Gln Arg Leu Ile Glu Lys Tyr Asn Gln Pro Phe Glu Asp Thr Pro 
        35                  40                  45              


Val Val Gln Met Ala Thr Leu Thr Tyr Glu Thr Pro Gln Gly Leu Arg 
    50                  55                  60                  


Ile Trp Gly Gly Arg Leu Ile Lys Glu Arg Asn Glu Gly Glu Ile Gln 
65                  70                  75                  80  


Pro Ala Val Pro Gln Ser Pro Leu Lys Asn Glu Leu Arg Arg Lys Tyr 
                85                  90                  95      


Leu Thr Gln Val Asp Ile Leu Leu Gln Gly Ala Glu Tyr Phe Glu Cys 
            100                 105                 110         


Ala Gly Asn Arg Ala Gly Arg Asp Val Arg Val Thr Pro Leu Pro Ser 
        115                 120                 125             


Leu Ala Ser Pro Ala Val Pro Ala Pro Gly Tyr Cys Ser Arg Ile Ser 
    130                 135                 140                 


Arg Lys Ser Pro Gly Asp Pro Ala Lys Pro Ala Ser Ser Pro Arg Glu 
145                 150                 155                 160 


Trp Asp Pro Leu His Pro Ser Ser Thr Asp Met Ala Leu Val Pro Arg 
                165                 170                 175     


Asn Asp Ser Leu Ser Leu Gln Glu Thr Ser Ser Ser Ser Phe Leu Ser 
            180                 185                 190         


Ser Gln Pro Phe Glu Asp Asp Asp Ile Cys Asn Val Thr Ile Ser Asp 
        195                 200                 205             


Leu Tyr Ala Gly Met Leu His Ser Met Ser Arg Leu Leu Ser Thr Lys 
    210                 215                 220                 


Pro Ser Ser Ile Ile Ser Thr Lys Thr Phe Ile Met Gln Asn Trp Asn 
225                 230                 235                 240 


Ser Arg Arg Arg His Arg Tyr Lys Ser Arg Met Asn Lys Thr Tyr Cys 
                245                 250                 255     


Lys Gly Ala Arg Arg Ser Gln Arg Ser Ser Lys Glu Asn Phe Ile Pro 
            260                 265                 270         


Cys Ser Glu Pro Val Lys Gly Thr Gly Ala Leu Arg Asp Cys Lys Asn 
        275                 280                 285             


Val Leu Asp Val Ser Cys Arg Lys Thr Gly Leu Lys Leu Glu Lys Ala 
    290                 295                 300                 


Phe Leu Glu Val Asn Arg Pro Gln Ile His Lys Leu Asp Pro Ser Trp 
305                 310                 315                 320 


Lys Glu Arg Lys Val Thr Pro Ser Lys Tyr Ser Ser Leu Ile Tyr Phe 
                325                 330                 335     


Asp Ser Ser Ala Thr Tyr Asn Leu Asp Glu Glu Asn Arg Phe Arg Thr 
            340                 345                 350         


Leu Lys Trp Leu Ile Ser Pro Val Lys Ile Val Ser Arg Pro Thr Ile 
        355                 360                 365             


Arg Gln Gly His Gly Glu Asn Arg Gln Arg Glu Ile Glu Ile Arg Phe 
    370                 375                 380                 


Asp Gln Leu His Arg Glu Tyr Cys Leu Ser Pro Arg Asn Gln Pro Arg 
385                 390                 395                 400 


Arg Met Cys Leu Pro Asp Ser Trp Ala Met Asn Met Tyr Arg Gly Gly 
                405                 410                 415     


Pro Ala Ser Pro Gly Gly Leu Gln Gly Leu Glu Thr Arg Arg Leu Ser 
            420                 425                 430         


Leu Pro Ser Ser Lys Ala Lys Ala Lys Ser Leu Ser Glu Ala Phe Glu 
        435                 440                 445             


Asn Leu Gly Lys Arg Ser Leu Glu Ala Gly Arg Cys Leu Pro Lys Ser 
    450                 455                 460                 


Asp Ser Ser Ser Ser Leu Pro Lys Thr Asn Pro Thr His Ser Ala Thr 
465                 470                 475                 480 


Arg Pro Gln Gln Thr Ser Asp Leu His Val Gln Gly Asn Ser Ser Gly 
                485                 490                 495     


Ile Phe Arg Lys Ser Val Ser Pro Ser Lys Thr Leu Ser Val Pro Asp 
            500                 505                 510         


Lys Glu Val Pro Gly His Gly Arg Asn Arg Tyr Asp Glu Ile Lys Glu 
        515                 520                 525             


Glu Phe Asp Lys Leu His Gln Lys Tyr Cys Leu Lys Ser Pro Gly Gln 
    530                 535                 540                 


Met Thr Val Pro Leu Cys Ile Gly Val Ser Thr Asp Lys Ala Ser Met 
545                 550                 555                 560 


Glu Val Arg Tyr Gln Thr Glu Gly Phe Leu Gly Lys Leu Asn Pro Asp 
                565                 570                 575     


Pro His Phe Gln Gly Phe Gln Lys Leu Pro Ser Ser Pro Leu Gly Cys 
            580                 585                 590         


Arg Lys Ser Leu Leu Gly Ser Thr Ala Ile Glu Ala Pro Ser Ser Thr 
        595                 600                 605             


Cys Val Ala Arg Ala Ile Thr Arg Asp Gly Thr Arg Asp His Gln Phe 
    610                 615                 620                 


Pro Ala Lys Arg Pro Arg Leu Ser Glu Pro Gln Gly Ser Gly Arg Gln 
625                 630                 635                 640 


Gly Asn Ser Leu Gly Ala Ser Asp Gly Val Asp Asn Thr Val Arg Pro 
                645                 650                 655     


Gly Asp Gln Gly Ser Ser Ser Gln Pro Asn Ser Glu Glu Arg Gly Glu 
            660                 665                 670         


Asn Thr Ser Tyr Arg Met Glu Glu Lys Ser Asp Phe Met Leu Glu Lys 
        675                 680                 685             


Leu Glu Thr Lys Ser Val 
    690                 


<210>  5012
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK1__Homo_sapiens__NP_000179

<400>  5012

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
        35                  40                  45              


Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
65                  70                  75                  80  


Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                85                  90                  95      


Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
            100                 105                 110         


Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
        115                 120                 125             


His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
145                 150                 155                 160 


Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                165                 170                 175     


Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
            180                 185                 190         


Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
    210                 215                 220                 


Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
305                 310                 315                 320 


Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                325                 330                 335     


Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
            340                 345                 350         


Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
        355                 360                 365             


Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
385                 390                 395                 400 


Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                405                 410                 415     


Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
            420                 425                 430         


Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
465                 470                 475                 480 


Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                485                 490                 495     


Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
            500                 505                 510         


Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
            580                 585                 590         


Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
625                 630                 635                 640 


Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
    690                 695                 700                 


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala 
                725                 730                 735     


Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
        755                 760                 765             


Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
865                 870                 875                 880 


Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
            900                 905                 910         


Thr Glu Ala Ser Ser 
        915         


<210>  5013
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK2__Homo_sapiens__NP_000180

<400>  5013

Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His 
1               5                   10                  15      


Asp Gln Val Gln Lys Val Asp Gln Tyr Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Leu Glu Ile Ser Lys Arg Phe Arg Lys Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe 
65                  70                  75                  80  


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Trp Val Lys 
                85                  90                  95      


Val Thr Asp Asn Gly Leu Gln Lys Val Glu Met Glu Asn Gln Ile Tyr 
            100                 105                 110         


Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp 
        115                 120                 125             


His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln 
145                 150                 155                 160 


Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys 
                165                 170                 175     


Ser Ser Gly Val Glu Gly Arg Asp Val Val Ala Leu Ile Arg Lys Ala 
            180                 185                 190         


Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp His Asn Cys 
    210                 215                 220                 


Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Asn Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Gln Glu Ile Asp Met Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Glu Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Lys Leu Ser Pro Glu Leu Leu Asn Thr Gly Arg Phe Glu Thr 
                325                 330                 335     


Lys Asp Ile Ser Asp Ile Glu Gly Glu Lys Asp Gly Ile Arg Lys Ala 
            340                 345                 350         


Arg Glu Val Leu Met Arg Leu Gly Leu Asp Pro Thr Gln Glu Asp Cys 
        355                 360                 365             


Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser 
    370                 375                 380                 


Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Gln Arg Ile Lys Glu Asn 
385                 390                 395                 400 


Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val 
                405                 410                 415     


Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Thr Val Arg 
            420                 425                 430         


Arg Leu Val Pro Gly Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu His Leu Gln Leu Ser 
465                 470                 475                 480 


His Asp Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu 
                485                 490                 495     


Arg Gly Leu Ser Lys Glu Thr His Ala Ser Ala Pro Val Lys Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg 
    530                 535                 540                 


Val Arg Asn Gly Lys Trp Gly Gly Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Gln Glu Val Met His Gly Thr Gly Asp Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys 
            580                 585                 590         


Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Asn Ser Leu Asp Glu Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala 
625                 630                 635                 640 


Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Gly Phe Glu Asp Pro His Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Arg Asn Val Glu Leu Val Glu Gly Glu Glu Gly Arg Met Cys 
    690                 695                 700                 


Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Phe Arg Thr Glu Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro 
                725                 730                 735     


Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe 
        755                 760                 765             


Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Arg Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Ala Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Lys 
865                 870                 875                 880 


Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Gln Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg 
            900                 905                 910         


Glu Ala Gly Gln Arg 
        915         


<210>  5014
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK3__Homo_sapiens__NP_002106

<400>  5014

Met Asp Ser Ile Gly Ser Ser Gly Leu Arg Gln Gly Glu Glu Thr Leu 
1               5                   10                  15      


Ser Cys Ser Glu Glu Gly Leu Pro Gly Pro Ser Asp Ser Ser Glu Leu 
            20                  25                  30          


Val Gln Glu Cys Leu Gln Gln Phe Lys Val Thr Arg Ala Gln Leu Gln 
        35                  40                  45              


Gln Ile Gln Ala Ser Leu Leu Gly Ser Met Glu Gln Ala Leu Arg Gly 
    50                  55                  60                  


Gln Ala Ser Pro Ala Pro Ala Val Arg Met Leu Pro Thr Tyr Val Gly 
65                  70                  75                  80  


Ser Thr Pro His Gly Thr Glu Gln Gly Asp Phe Val Val Leu Glu Leu 
                85                  90                  95      


Gly Ala Thr Gly Ala Ser Leu Arg Val Leu Trp Val Thr Leu Thr Gly 
            100                 105                 110         


Ile Glu Gly His Arg Val Glu Pro Arg Ser Gln Glu Phe Val Ile Pro 
        115                 120                 125             


Gln Glu Val Met Leu Gly Ala Gly Gln Gln Leu Phe Asp Phe Ala Ala 
    130                 135                 140                 


His Cys Leu Ser Glu Phe Leu Asp Ala Gln Pro Val Asn Lys Gln Gly 
145                 150                 155                 160 


Leu Gln Leu Gly Phe Ser Phe Ser Phe Pro Cys His Gln Thr Gly Leu 
                165                 170                 175     


Asp Arg Ser Thr Leu Ile Ser Trp Thr Lys Gly Phe Arg Cys Ser Gly 
            180                 185                 190         


Val Glu Gly Gln Asp Val Val Gln Leu Leu Arg Asp Ala Ile Arg Arg 
        195                 200                 205             


Gln Gly Ala Tyr Asn Ile Asp Val Val Ala Val Val Asn Asp Thr Val 
    210                 215                 220                 


Gly Thr Met Met Gly Cys Glu Pro Gly Val Arg Pro Cys Glu Val Gly 
225                 230                 235                 240 


Leu Val Val Asp Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu Ala Arg 
                245                 250                 255     


His Val Ala Val Leu Asp Glu Asp Arg Gly Arg Val Cys Val Ser Val 
            260                 265                 270         


Glu Trp Gly Ser Phe Ser Asp Asp Gly Ala Leu Gly Pro Val Leu Thr 
        275                 280                 285             


Thr Phe Asp His Thr Leu Asp His Glu Ser Leu Asn Pro Gly Ala Gln 
    290                 295                 300                 


Arg Phe Glu Lys Met Ile Gly Gly Leu Tyr Leu Gly Glu Leu Val Arg 
305                 310                 315                 320 


Leu Val Leu Ala His Leu Ala Arg Cys Gly Val Leu Phe Gly Gly Cys 
                325                 330                 335     


Thr Ser Pro Ala Leu Leu Ser Gln Gly Ser Ile Leu Leu Glu His Val 
            340                 345                 350         


Ala Glu Met Glu Asp Pro Ser Thr Gly Ala Ala Arg Val His Ala Ile 
        355                 360                 365             


Leu Gln Asp Leu Gly Leu Ser Pro Gly Ala Ser Asp Val Glu Leu Val 
    370                 375                 380                 


Gln His Val Cys Ala Ala Val Cys Thr Arg Ala Ala Gln Leu Cys Ala 
385                 390                 395                 400 


Ala Ala Leu Ala Ala Val Leu Ser Cys Leu Gln His Ser Arg Glu Gln 
                405                 410                 415     


Gln Thr Leu Gln Val Ala Val Ala Thr Gly Gly Arg Val Cys Glu Arg 
            420                 425                 430         


His Pro Arg Phe Cys Ser Val Leu Gln Gly Thr Val Met Leu Leu Ala 
        435                 440                 445             


Pro Glu Cys Asp Val Ser Leu Ile Pro Ser Val Asp Gly Gly Gly Arg 
    450                 455                 460                 


Gly Val Ala Met Val Thr Ala Val Ala Ala Arg Leu Ala Ala His Arg 
465                 470                 475                 480 


Arg Leu Leu Glu Glu Thr Leu Ala Pro Phe Arg Leu Asn His Asp Gln 
                485                 490                 495     


Leu Ala Ala Val Gln Ala Gln Met Arg Lys Ala Met Ala Lys Gly Leu 
            500                 505                 510         


Arg Gly Glu Ala Ser Ser Leu Arg Met Leu Pro Thr Phe Val Arg Ala 
        515                 520                 525             


Thr Pro Asp Gly Ser Glu Arg Gly Asp Phe Leu Ala Leu Asp Leu Gly 
    530                 535                 540                 


Gly Thr Asn Phe Arg Val Leu Leu Val Arg Val Thr Thr Gly Val Gln 
545                 550                 555                 560 


Ile Thr Ser Glu Ile Tyr Ser Ile Pro Glu Thr Val Ala Gln Gly Ser 
                565                 570                 575     


Gly Gln Gln Leu Phe Asp His Ile Val Asp Cys Ile Val Asp Phe Gln 
            580                 585                 590         


Gln Lys Gln Gly Leu Ser Gly Gln Ser Leu Pro Leu Gly Phe Thr Phe 
        595                 600                 605             


Ser Phe Pro Cys Arg Gln Leu Gly Leu Asp Gln Gly Ile Leu Leu Asn 
    610                 615                 620                 


Trp Thr Lys Gly Phe Lys Ala Ser Asp Cys Glu Gly Gln Asp Val Val 
625                 630                 635                 640 


Ser Leu Leu Arg Glu Ala Ile Thr Arg Arg Gln Ala Val Glu Leu Asn 
                645                 650                 655     


Val Val Ala Ile Val Asn Asp Thr Val Gly Thr Met Met Ser Cys Gly 
            660                 665                 670         


Tyr Glu Asp Pro Arg Cys Glu Ile Gly Leu Ile Val Gly Thr Gly Thr 
        675                 680                 685             


Asn Ala Cys Tyr Met Glu Glu Leu Arg Asn Val Ala Gly Val Pro Gly 
    690                 695                 700                 


Asp Ser Gly Arg Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp 
705                 710                 715                 720 


Asp Gly Ser Leu Ala Met Leu Ser Thr Arg Phe Asp Ala Ser Val Asp 
                725                 730                 735     


Gln Ala Ser Ile Asn Pro Gly Lys Gln Arg Phe Glu Lys Met Ile Ser 
            740                 745                 750         


Gly Met Tyr Leu Gly Glu Ile Val Arg His Ile Leu Leu His Leu Thr 
        755                 760                 765             


Ser Leu Gly Val Leu Phe Arg Gly Gln Gln Ile Gln Arg Leu Gln Thr 
    770                 775                 780                 


Arg Asp Ile Phe Lys Thr Lys Phe Leu Ser Glu Ile Glu Ser Asp Ser 
785                 790                 795                 800 


Leu Ala Leu Arg Gln Val Arg Ala Ile Leu Glu Asp Leu Gly Leu Pro 
                805                 810                 815     


Leu Thr Ser Asp Asp Ala Leu Met Val Leu Glu Val Cys Gln Ala Val 
            820                 825                 830         


Ser Gln Arg Ala Ala Gln Leu Cys Gly Ala Gly Val Ala Ala Val Val 
        835                 840                 845             


Glu Lys Ile Arg Glu Asn Arg Gly Leu Glu Glu Leu Ala Val Ser Val 
    850                 855                 860                 


Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro Arg Phe Ser Ser Leu 
865                 870                 875                 880 


Val Ala Ala Thr Val Arg Glu Leu Ala Pro Arg Cys Val Val Thr Phe 
                885                 890                 895     


Leu Gln Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Val Thr Ala 
            900                 905                 910         


Val Ala Cys Arg Leu Ala Gln Leu Thr Arg Val 
        915                 920             


<210>  5015
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HKDC1__Homo_sapiens__NP_079406

<400>  5015

Met Phe Ala Val His Leu Met Ala Phe Tyr Phe Ser Lys Leu Lys Glu 
1               5                   10                  15      


Asp Gln Ile Lys Lys Val Asp Arg Phe Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Asp Thr Leu Leu Asp Ile Met Arg Arg Phe Arg Ala Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Ala Lys Asp Thr Asn Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ala Ile Pro Asp Gly Ser Glu Asn Gly Glu Phe 
65                  70                  75                  80  


Leu Ser Leu Asp Leu Gly Gly Ser Lys Phe Arg Val Leu Lys Val Gln 
                85                  90                  95      


Val Ala Glu Glu Gly Lys Arg His Val Gln Met Glu Ser Gln Phe Tyr 
            100                 105                 110         


Pro Thr Pro Asn Glu Ile Ile Arg Gly Asn Gly Thr Glu Leu Phe Glu 
        115                 120                 125             


Tyr Val Ala Asp Cys Leu Ala Asp Phe Met Lys Thr Lys Asp Leu Lys 
    130                 135                 140                 


His Lys Lys Leu Pro Leu Gly Leu Thr Phe Ser Phe Pro Cys Arg Gln 
145                 150                 155                 160 


Thr Lys Leu Glu Glu Gly Val Leu Leu Ser Trp Thr Lys Lys Phe Lys 
                165                 170                 175     


Ala Arg Gly Val Gln Asp Thr Asp Val Val Ser Arg Leu Thr Lys Ala 
            180                 185                 190         


Met Arg Arg His Lys Asp Met Asp Val Asp Ile Leu Ala Leu Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Asp Asp Pro Tyr Cys 
    210                 215                 220                 


Glu Val Gly Val Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Asp Met Ser Asn Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ala Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Leu Asp Leu Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Leu Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Leu Lys Met Ala Lys Ala Gly Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Glu Lys Ser Ser Ala Leu His Thr Lys Gly Lys Ile Glu Thr 
                325                 330                 335     


Arg His Val Ala Ala Met Glu Lys Tyr Lys Glu Gly Leu Ala Asn Thr 
            340                 345                 350         


Arg Glu Ile Leu Val Asp Leu Gly Leu Glu Pro Ser Glu Ala Asp Cys 
        355                 360                 365             


Ile Ala Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Cys Ala Ala Ala Leu Ala Ala Ile Leu Thr Arg Leu Arg Glu Asn 
385                 390                 395                 400 


Lys Lys Val Glu Arg Leu Arg Thr Thr Val Gly Met Asp Gly Thr Leu 
                405                 410                 415     


Tyr Lys Ile His Pro Gln Tyr Pro Lys Arg Leu His Lys Val Val Arg 
            420                 425                 430         


Lys Leu Val Pro Ser Cys Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Thr Lys Gly Ala Ala Met Val Thr Ala Val Ala Ser Arg Val Gln 
    450                 455                 460                 


Ala Gln Arg Lys Gln Ile Asp Arg Val Leu Ala Leu Phe Gln Leu Thr 
465                 470                 475                 480 


Arg Glu Gln Leu Val Asp Val Gln Ala Lys Met Arg Ala Glu Leu Glu 
                485                 490                 495     


Tyr Gly Leu Lys Lys Lys Ser His Gly Leu Ala Thr Val Arg Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Gly Leu Pro Asp Gly Thr Glu Lys Gly Lys Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Arg Arg Ser Val Arg Met Tyr Asn Lys Ile Phe Ala 
545                 550                 555                 560 


Ile Pro Leu Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His 
                565                 570                 575     


Ile Val Gln Cys Ile Ala Asp Phe Leu Asp Tyr Met Gly Leu Lys Gly 
            580                 585                 590         


Ala Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Arg Gln Met 
        595                 600                 605             


Ser Ile Asp Lys Gly Thr Leu Ile Gly Trp Thr Lys Gly Phe Lys Ala 
    610                 615                 620                 


Thr Asp Cys Glu Gly Glu Asp Val Val Asp Met Leu Arg Glu Ala Ile 
625                 630                 635                 640 


Lys Arg Arg Asn Glu Phe Asp Leu Asp Ile Val Ala Val Val Asn Asp 
                645                 650                 655     


Thr Val Gly Thr Met Met Thr Cys Gly Tyr Glu Asp Pro Asn Cys Glu 
            660                 665                 670         


Ile Gly Leu Ile Ala Gly Thr Gly Ser Asn Met Cys Tyr Met Glu Asp 
        675                 680                 685             


Met Arg Asn Ile Glu Met Val Glu Gly Gly Glu Gly Lys Met Cys Ile 
    690                 695                 700                 


Asn Thr Glu Trp Gly Gly Phe Gly Asp Asn Gly Cys Ile Asp Asp Ile 
705                 710                 715                 720 


Arg Thr Arg Tyr Asp Thr Glu Val Asp Glu Gly Ser Leu Asn Pro Gly 
                725                 730                 735     


Lys Gln Arg Tyr Glu Lys Met Thr Ser Gly Met Tyr Leu Gly Glu Ile 
            740                 745                 750         


Val Arg Gln Ile Leu Ile Asp Leu Thr Lys Gln Gly Leu Leu Phe Arg 
        755                 760                 765             


Gly Gln Ile Ser Glu Arg Leu Arg Thr Arg Gly Ile Phe Glu Thr Lys 
    770                 775                 780                 


Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg 
785                 790                 795                 800 


Arg Ile Leu Gln Gln Leu Gly Leu Asp Ser Thr Cys Glu Asp Ser Ile 
                805                 810                 815     


Val Val Lys Glu Val Cys Gly Ala Val Ser Arg Arg Ala Ala Gln Leu 
            820                 825                 830         


Cys Gly Ala Gly Leu Ala Ala Ile Val Glu Lys Arg Arg Glu Asp Gln 
        835                 840                 845             


Gly Leu Glu His Leu Arg Ile Thr Val Gly Val Asp Gly Thr Leu Tyr 
    850                 855                 860                 


Lys Leu His Pro His Phe Ser Arg Ile Leu Gln Glu Thr Val Lys Glu 
865                 870                 875                 880 


Leu Ala Pro Arg Cys Asp Val Thr Phe Met Leu Ser Glu Asp Gly Ser 
                885                 890                 895     


Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Lys Arg Leu Gln Gln 
            900                 905                 910         


Ala Gln Lys Glu Asn 
        915         


<210>  5016
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A__Homo_sapiens__NP_001229687

<400>  5016

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  5017
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B__Homo_sapiens__NP_005505

<400>  5017

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  5018
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C__Homo_sapiens__NP_001229971

<400>  5018

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 
        355                 360                 365     


<210>  5019
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DMA__Homo_sapiens__NP_006111

<400>  5019

Met Gly His Glu Gln Asn Gln Gly Ala Ala Leu Leu Gln Met Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Leu Pro His Ser Trp Ala Val Pro Glu Ala Pro Thr 
            20                  25                  30          


Pro Met Trp Pro Asp Asp Leu Gln Asn His Thr Phe Leu His Thr Val 
        35                  40                  45              


Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly Leu Ser Glu Ala Tyr Asp 
    50                  55                  60                  


Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser Gln Asn Thr Arg Val Pro 
65                  70                  75                  80  


Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln Glu Gln Gly Asp Ala Pro 
                85                  90                  95      


Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu Trp Met Ile Gln Gln Ile 
            100                 105                 110         


Gly Pro Lys Leu Asp Gly Lys Ile Pro Val Ser Arg Gly Phe Pro Ile 
        115                 120                 125             


Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly Lys Pro Asn Thr 
    130                 135                 140                 


Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met Leu Thr Val Asn 
145                 150                 155                 160 


Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly Pro Thr Phe Val 
                165                 170                 175     


Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser Tyr Leu Asn Phe 
            180                 185                 190         


Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val Thr His Glu Ile 
        195                 200                 205             


Asp Arg Tyr Thr Ala Ile Ala Tyr Trp Val Pro Arg Asn Ala Leu Pro 
    210                 215                 220                 


Ser Asp Leu Leu Glu Asn Val Leu Cys Gly Val Ala Phe Gly Leu Gly 
225                 230                 235                 240 


Val Leu Gly Ile Ile Val Gly Ile Val Leu Ile Ile Tyr Phe Arg Lys 
                245                 250                 255     


Pro Cys Ser Gly Asp 
            260     


<210>  5020
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DMB__Homo_sapiens__NP_002109

<400>  5020

Met Ile Thr Phe Leu Pro Leu Leu Leu Gly Leu Ser Leu Gly Cys Thr 
1               5                   10                  15      


Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 
            20                  25                  30          


Asp Ala Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 
        35                  40                  45              


Asp Leu Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys 
    50                  55                  60                  


Glu Phe Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu 
65                  70                  75                  80  


Asn Gln Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn 
                85                  90                  95      


Cys Ala Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
            100                 105                 110         


Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
        115                 120                 125             


Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 
    130                 135                 140                 


Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 
145                 150                 155                 160 


Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
                165                 170                 175     


Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 
            180                 185                 190         


Val Val Glu His Thr Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp Thr 
        195                 200                 205             


Pro Gly Leu Ser Pro Met Gln Thr Leu Lys Val Ser Val Ser Ala Val 
    210                 215                 220                 


Thr Leu Gly Leu Gly Leu Ile Ile Phe Ser Leu Gly Val Ile Ser Trp 
225                 230                 235                 240 


Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser Asn Tyr 
                245                 250                 255     


Ser Glu Gly Trp His Ile Ser 
            260             


<210>  5021
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DOA__Homo_sapiens__NP_002110

<400>  5021

Met Ala Leu Arg Ala Gly Leu Val Leu Gly Phe His Thr Leu Met Thr 
1               5                   10                  15      


Leu Leu Ser Pro Gln Glu Ala Gly Ala Thr Lys Ala Asp His Met Gly 
            20                  25                  30          


Ser Tyr Gly Pro Ala Phe Tyr Gln Ser Tyr Gly Ala Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Glu Glu Gln Leu Phe Ser Val Asp Leu Lys Lys 
    50                  55                  60                  


Ser Glu Ala Val Trp Arg Leu Pro Glu Phe Gly Asp Phe Ala Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Gly Leu Ala Gly Ile Ala Ala Ile Lys Ala His Leu 
                85                  90                  95      


Asp Ile Leu Val Glu Arg Ser Asn Arg Ser Arg Ala Ile Asn Val Pro 
            100                 105                 110         


Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly Gln Pro 
        115                 120                 125             


Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val Ile Asn 
    130                 135                 140                 


Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val Ala Gln 
145                 150                 155                 160 


Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe His Tyr 
                165                 170                 175     


Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp Glu Leu Gln Val 
        195                 200                 205             


Pro Ile Pro Pro Pro Asp Ala Met Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ala Ile Gly Leu Val Gly Phe Leu Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Met Gly Thr Tyr Val Ser Ser Val Pro Arg 
                245                 250 


<210>  5022
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DOB__Homo_sapiens__NP_002111

<400>  5022

Met Gly Ser Gly Trp Val Pro Trp Val Val Ala Leu Leu Val Asn Leu 
1               5                   10                  15      


Thr Arg Leu Asp Ser Ser Met Thr Gln Gly Thr Asp Ser Pro Glu Asp 
            20                  25                  30          


Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr Phe Thr Asn Gly Thr Glu 
        35                  40                  45              


Lys Val Gln Phe Val Val Arg Phe Ile Phe Asn Leu Glu Glu Tyr Val 
    50                  55                  60                  


Arg Phe Asp Ser Asp Val Gly Met Phe Val Ala Leu Thr Lys Leu Gly 
65                  70                  75                  80  


Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg Leu Asp Leu Leu Glu Arg 
                85                  90                  95      


Ser Arg Gln Ala Val Asp Gly Val Cys Arg His Asn Tyr Arg Leu Gly 
            100                 105                 110         


Ala Pro Phe Thr Val Gly Arg Lys Val Gln Pro Glu Val Thr Val Tyr 
        115                 120                 125             


Pro Glu Arg Thr Pro Leu Leu His Gln His Asn Leu Leu His Cys Ser 
    130                 135                 140                 


Val Thr Gly Phe Tyr Pro Gly Asp Ile Lys Ile Lys Trp Phe Leu Asn 
145                 150                 155                 160 


Gly Gln Glu Glu Arg Ala Gly Val Met Ser Thr Gly Pro Ile Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Thr Val Val Met Leu Glu Met Thr Pro Glu 
            180                 185                 190         


Leu Gly His Val Tyr Thr Cys Leu Val Asp His Ser Ser Leu Leu Ser 
        195                 200                 205             


Pro Val Ser Val Glu Trp Arg Ala Gln Ser Glu Tyr Ser Trp Arg Lys 
    210                 215                 220                 


Met Leu Ser Gly Ile Ala Ala Phe Leu Leu Gly Leu Ile Phe Leu Leu 
225                 230                 235                 240 


Val Gly Ile Val Ile Gln Leu Arg Ala Gln Lys Gly Tyr Val Arg Thr 
                245                 250                 255     


Gln Met Ser Gly Asn Glu Val Ser Arg Ala Val Leu Leu Pro Gln Ser 
            260                 265                 270         


Cys 
    


<210>  5023
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DPA1__Homo_sapiens__NP_001229454

<400>  5023

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  5024
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DPB1__Homo_sapiens__NP_002112

<400>  5024

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  5025
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DQA1__Homo_sapiens__NP_002113

<400>  5025

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  5026
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DQA2__Homo_sapiens__NP_064440

<400>  5026

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Ala 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Phe Tyr Gln Ser His Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Thr 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Met Phe Ser Lys Phe Ile Ser Phe 
65                  70                  75                  80  


Asp Pro Gln Ser Ala Leu Arg Asn Met Ala Val Gly Lys His Thr Leu 
                85                  90                  95      


Glu Phe Met Met Arg Gln Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Phe Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Leu Leu 
                245                 250                 255 


<210>  5027
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DQB1__Homo_sapiens__NP_001230890

<400>  5027

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  5028
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DQB2__Homo_sapiens__NP_001185787

<400>  5028

Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala Ala Val Thr Val 
1               5                   10                  15      


Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala Arg Asp Phe Pro 
            20                  25                  30          


Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu 
    50                  55                  60                  


Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu 
                85                  90                  95      


Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala 
            100                 105                 110         


Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile 
        115                 120                 125             


Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro 
            180                 185                 190         


Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln 
        195                 200                 205             


Ser Pro Ile Thr Val Glu Trp Arg Pro Arg Gly Pro Pro Pro Ala Gly 
    210                 215                 220                 


Leu Leu His 
225         


<210>  5029
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DRA__Homo_sapiens__NP_061984

<400>  5029

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Leu Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  5030
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DRB1__Homo_sapiens__NP_001230894

<400>  5030

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  5031
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DRB3__Homo_sapiens__NP_072049

<400>  5031

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  5032
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DRB4__Homo_sapiens__NP_068818

<400>  5032

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Leu Leu Ser 
            260                 265     


<210>  5033
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-DRB5__Homo_sapiens__NP_002116

<400>  5033

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Tyr Met Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asp Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Lys Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu His Pro Thr Gly Leu Val Ser 
            260                 265     


<210>  5034
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-E__Homo_sapiens__NP_005507

<400>  5034

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  5035
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-F__Homo_sapiens__NP_001091948

<400>  5035

Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      


Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  


Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  


Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      


Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             


Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 


Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     


Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Gln Ser Pro Gln 
        195                 200                 205             


Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly 
    210                 215                 220                 


Ala Val Val Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys 
225                 230                 235                 240 


Ser Ser Asp Arg Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val 
                245                 250                 


<210>  5036
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-G__Homo_sapiens__NP_002118

<400>  5036

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  5037
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLCS__Homo_sapiens__XP_005261010

<400>  5037

Met Leu Ile Thr Leu Cys Tyr Leu Tyr Leu Trp Ala Arg Trp Gly Arg 
1               5                   10                  15      


Arg Pro Ala Glu Leu Val Arg Ala Thr Val Arg Arg Leu Arg Ala Ser 
            20                  25                  30          


Arg Cys Ser Phe Thr Phe Cys Gly Ala Ala Ala Gln Pro Pro Gly Ala 
        35                  40                  45              


Arg Val Cys Leu Ser Arg Gly Gly Arg Val Phe Cys Val Ser Asp Ser 
    50                  55                  60                  


Gln Ser Ile Glu Asp Leu Asn Lys Trp Ala Leu Phe Leu Val Ser Pro 
65                  70                  75                  80  


Phe Ile Leu Glu Ala Glu His Ile Ala Phe Val Thr Glu Ser Ile Trp 
                85                  90                  95      


Val Gln Ser Glu Asn Leu Gln Arg Ser Ser Ser Ser Glu Thr Ile Val 
            100                 105                 110         


Lys Trp Ser Asp Cys Cys Leu Pro Leu Ala Cys Arg Pro Gly Asp Pro 
        115                 120                 125             


Tyr Arg Leu Ile Ala Glu Ala Ser Val Asp Asn Phe Ser Lys Leu Gly 
    130                 135                 140                 


Val Ala Phe Met Glu Asp Arg Leu His Met Asp Asn Gly Leu Val Pro 
145                 150                 155                 160 


Gln Lys Ile Val Ser Val His Leu Gln Asp Ser Thr Leu Lys Glu Val 
                165                 170                 175     


Lys Asp Gln Val Ser Asn Lys Gln Ala Gln Ile Leu Glu Pro Lys Pro 
            180                 185                 190         


Glu Pro Ser Leu Glu Ile Lys Pro Glu Gln Asp Gly Met Glu His Val 
        195                 200                 205             


Gly Arg Asp Asp Pro Lys Ala Leu Gly Glu Glu Pro Lys Gln Arg Arg 
    210                 215                 220                 


Gly Ser Ala Ser Gly Ser Glu Pro Ala Gly Asp Ser Asp Arg Gly Gly 
225                 230                 235                 240 


Gly Pro Val Glu His Tyr His Leu His Leu Ser Ser Cys His Glu Cys 
                245                 250                 255     


Leu Glu Leu Glu Asn Ser Thr Ile Glu Ser Val Lys Phe Ala Ser Ala 
            260                 265                 270         


Glu Asn Ile Pro Asp Leu Pro Tyr Asp Tyr Ser Ser Ser Leu Glu Ser 
        275                 280                 285             


Val Ala Asp Glu Thr Ser Pro Glu Arg Glu Gly Arg Arg Val Asn Leu 
    290                 295                 300                 


Thr Gly Lys Ala Pro Asn Ile Leu Leu Tyr Val Gly Ser Asp Ser Gln 
305                 310                 315                 320 


Glu Ala Leu Gly Arg Phe His Glu Val Arg Ser Val Leu Ala Asp Cys 
                325                 330                 335     


Val Asp Ile Asp Ser Tyr Ile Leu Tyr His Leu Leu Glu Asp Ser Ala 
            340                 345                 350         


Leu Arg Asp Pro Trp Thr Asp Asn Cys Leu Leu Leu Val Ile Ala Thr 
        355                 360                 365             


Arg Glu Ser Ile Pro Glu Asp Leu Tyr Gln Lys Phe Met Ala Tyr Leu 
    370                 375                 380                 


Ser Gln Gly Gly Lys Val Leu Gly Leu Ser Ser Ser Phe Thr Phe Gly 
385                 390                 395                 400 


Gly Phe Gln Val Thr Ser Lys Gly Ala Leu His Lys Thr Val Gln Asn 
                405                 410                 415     


Leu Val Phe Ser Lys Ala Asp Gln Ser Glu Val Lys Leu Ser Val Leu 
            420                 425                 430         


Ser Ser Gly Cys Arg Tyr Gln Glu Gly Pro Val Arg Leu Ser Pro Gly 
        435                 440                 445             


Arg Leu Gln Gly His Leu Glu Asn Glu Asp Lys Asp Arg Met Ile Val 
    450                 455                 460                 


His Val Pro Phe Gly Thr Arg Gly Gly Glu Ala Val Leu Cys Gln Val 
465                 470                 475                 480 


His Leu Glu Leu Pro Pro Ser Ser Asn Ile Val Gln Thr Pro Glu Asp 
                485                 490                 495     


Phe Asn Leu Leu Lys Ser Ser Asn Phe Arg Arg Tyr Glu Val Leu Arg 
            500                 505                 510         


Glu Ile Leu Thr Thr Leu Gly Leu Ser Cys Asp Met Lys Gln Val Pro 
        515                 520                 525             


Ala Leu Thr Pro Leu Tyr Leu Leu Ser Ala Ala Glu Glu Ile Arg Asp 
    530                 535                 540                 


Pro Leu Met Gln Trp Leu Gly Lys His Val Asp Ser Glu Gly Glu Ile 
545                 550                 555                 560 


Lys Ser Gly Gln Leu Ser Leu Arg Phe Val Ser Ser Tyr Val Ser Glu 
                565                 570                 575     


Val Glu Ile Thr Pro Ser Cys Ile Pro Val Val Thr Asn Met Glu Ala 
            580                 585                 590         


Phe Ser Ser Glu His Phe Asn Leu Glu Ile Tyr Arg Gln Asn Leu Gln 
        595                 600                 605             


Thr Lys Gln Leu Gly Lys Val Ile Leu Phe Ala Glu Val Thr Pro Thr 
    610                 615                 620                 


Thr Met Arg Leu Leu Asp Gly Leu Met Phe Gln Thr Pro Gln Glu Met 
625                 630                 635                 640 


Gly Leu Ile Val Ile Ala Ala Arg Gln Thr Glu Gly Lys Gly Arg Gly 
                645                 650                 655     


Gly Asn Val Trp Leu Ser Pro Val Gly Cys Ala Leu Ser Thr Leu Leu 
            660                 665                 670         


Ile Ser Ile Pro Leu Arg Ser Gln Leu Gly Gln Arg Ile Pro Phe Val 
        675                 680                 685             


Gln His Leu Met Ser Val Ala Val Val Glu Ala Val Arg Ser Ile Pro 
    690                 695                 700                 


Glu Tyr Gln Asp Ile Asn Leu Arg Val Lys Trp Pro Asn Asp Ile Tyr 
705                 710                 715                 720 


Tyr Ser Asp Leu Met Lys Ile Gly Gly Val Leu Val Asn Ser Thr Leu 
                725                 730                 735     


Met Gly Glu Thr Phe Tyr Ile Leu Ile Gly Cys Gly Phe Asn Val Thr 
            740                 745                 750         


Asn Ser Asn Pro Thr Ile Cys Ile Asn Asp Leu Ile Thr Glu Tyr Asn 
        755                 760                 765             


Lys Gln His Lys Ala Glu Leu Lys Pro Leu Arg Ala Asp Tyr Leu Ile 
    770                 775                 780                 


Ala Arg Val Val Thr Val Leu Glu Lys Leu Ile Lys Glu Phe Gln Asp 
785                 790                 795                 800 


Lys Gly Pro Asn Ser Val Leu Pro Leu Tyr Tyr Arg Tyr Trp Val His 
                805                 810                 815     


Ser Gly Gln Gln Val His Leu Gly Ser Ala Glu Gly Pro Lys Val Ser 
            820                 825                 830         


Ile Val Gly Leu Asp Asp Ser Gly Phe Leu Gln Val His Gln Glu Gly 
        835                 840                 845             


Gly Glu Val Val Thr Val His Pro Asp Gly Asn Ser Phe Asp Met Leu 
    850                 855                 860                 


Arg Asn Leu Ile Leu Pro Lys Arg Arg 
865                 870             


<210>  5038
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLF__Homo_sapiens__NP_002117

<400>  5038

Met Glu Lys Met Ser Arg Pro Leu Pro Leu Asn Pro Thr Phe Ile Pro 
1               5                   10                  15      


Pro Pro Tyr Gly Val Leu Arg Ser Leu Leu Glu Asn Pro Leu Lys Leu 
            20                  25                  30          


Pro Leu His His Glu Asp Ala Phe Ser Lys Asp Lys Asp Lys Glu Lys 
        35                  40                  45              


Lys Leu Asp Asp Glu Ser Asn Ser Pro Thr Val Pro Gln Ser Ala Phe 
    50                  55                  60                  


Leu Gly Pro Thr Leu Trp Asp Lys Thr Leu Pro Tyr Asp Gly Asp Thr 
65                  70                  75                  80  


Phe Gln Leu Glu Tyr Met Asp Leu Glu Glu Phe Leu Ser Glu Asn Gly 
                85                  90                  95      


Ile Pro Pro Ser Pro Ser Gln His Asp His Ser Pro His Pro Pro Gly 
            100                 105                 110         


Leu Gln Pro Ala Ser Ser Ala Ala Pro Ser Val Met Asp Leu Ser Ser 
        115                 120                 125             


Arg Ala Ser Ala Pro Leu His Pro Gly Ile Pro Ser Pro Asn Cys Met 
    130                 135                 140                 


Gln Ser Pro Ile Arg Pro Gly Gln Leu Leu Pro Ala Asn Arg Asn Thr 
145                 150                 155                 160 


Pro Ser Pro Ile Asp Pro Asp Thr Ile Gln Val Pro Val Gly Tyr Glu 
                165                 170                 175     


Pro Asp Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly Gln Glu Met 
            180                 185                 190         


Phe Asp Pro Arg Lys Arg Lys Phe Ser Glu Glu Glu Leu Lys Pro Gln 
        195                 200                 205             


Pro Met Ile Lys Lys Ala Arg Lys Val Phe Ile Pro Asp Asp Leu Lys 
    210                 215                 220                 


Asp Asp Lys Tyr Trp Ala Arg Arg Arg Lys Asn Asn Met Ala Ala Lys 
225                 230                 235                 240 


Arg Ser Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ala Ile Arg 
                245                 250                 255     


Ala Ser Phe Leu Glu Lys Glu Asn Ser Ala Leu Arg Gln Glu Val Ala 
            260                 265                 270         


Asp Leu Arg Lys Glu Leu Gly Lys Cys Lys Asn Ile Leu Ala Lys Tyr 
        275                 280                 285             


Glu Ala Arg His Gly Pro Leu 
    290                 295 


<210>  5039
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLTF__Homo_sapiens__NP_003062

<400>  5039

Met Ser Trp Met Phe Lys Arg Asp Pro Val Trp Lys Tyr Leu Gln Thr 
1               5                   10                  15      


Val Gln Tyr Gly Val His Gly Asn Phe Pro Arg Leu Ser Tyr Pro Thr 
            20                  25                  30          


Phe Phe Pro Arg Phe Glu Phe Gln Asp Val Ile Pro Pro Asp Asp Phe 
        35                  40                  45              


Leu Thr Ser Asp Glu Glu Val Asp Ser Val Leu Phe Gly Ser Leu Arg 
    50                  55                  60                  


Gly His Val Val Gly Leu Arg Tyr Tyr Thr Gly Val Val Asn Asn Asn 
65                  70                  75                  80  


Glu Met Val Ala Leu Gln Arg Asp Pro Asn Asn Pro Tyr Asp Lys Asn 
                85                  90                  95      


Ala Ile Lys Val Asn Asn Val Asn Gly Asn Gln Val Gly His Leu Lys 
            100                 105                 110         


Lys Glu Leu Ala Gly Ala Leu Ala Tyr Ile Met Asp Asn Lys Leu Ala 
        115                 120                 125             


Gln Ile Glu Gly Val Val Pro Phe Gly Ala Asn Asn Ala Phe Thr Met 
    130                 135                 140                 


Pro Leu His Met Thr Phe Trp Gly Lys Glu Glu Asn Arg Lys Ala Val 
145                 150                 155                 160 


Ser Asp Gln Leu Lys Lys His Gly Phe Lys Leu Gly Pro Ala Pro Lys 
                165                 170                 175     


Thr Leu Gly Phe Asn Leu Glu Ser Gly Trp Gly Ser Gly Arg Ala Gly 
            180                 185                 190         


Pro Ser Tyr Ser Met Pro Val His Ala Ala Val Gln Met Thr Thr Glu 
        195                 200                 205             


Gln Leu Lys Thr Glu Phe Asp Lys Leu Phe Glu Asp Leu Lys Glu Asp 
    210                 215                 220                 


Asp Lys Thr His Glu Met Glu Pro Ala Glu Ala Ile Glu Thr Pro Leu 
225                 230                 235                 240 


Leu Pro His Gln Lys Gln Ala Leu Ala Trp Met Val Ser Arg Glu Asn 
                245                 250                 255     


Ser Lys Glu Leu Pro Pro Phe Trp Glu Gln Arg Asn Asp Leu Tyr Tyr 
            260                 265                 270         


Asn Thr Ile Thr Asn Phe Ser Glu Lys Asp Arg Pro Glu Asn Val His 
        275                 280                 285             


Gly Gly Ile Leu Ala Asp Asp Met Gly Leu Gly Lys Thr Leu Thr Ala 
    290                 295                 300                 


Ile Ala Val Ile Leu Thr Asn Phe His Asp Gly Arg Pro Leu Pro Ile 
305                 310                 315                 320 


Glu Arg Val Lys Lys Asn Leu Leu Lys Lys Glu Tyr Asn Val Asn Asp 
                325                 330                 335     


Asp Ser Met Lys Leu Gly Gly Asn Asn Thr Ser Glu Lys Ala Asp Gly 
            340                 345                 350         


Leu Ser Lys Asp Ala Ser Arg Cys Ser Glu Gln Pro Ser Ile Ser Asp 
        355                 360                 365             


Ile Lys Glu Lys Ser Lys Phe Arg Met Ser Glu Leu Ser Ser Ser Arg 
    370                 375                 380                 


Pro Lys Arg Arg Lys Thr Ala Val Gln Tyr Ile Glu Ser Ser Asp Ser 
385                 390                 395                 400 


Glu Glu Ile Glu Thr Ser Glu Leu Pro Gln Lys Met Lys Gly Lys Leu 
                405                 410                 415     


Lys Asn Val Gln Ser Glu Thr Lys Gly Arg Ala Lys Ala Gly Ser Ser 
            420                 425                 430         


Lys Val Ile Glu Asp Val Ala Phe Ala Cys Ala Leu Thr Ser Ser Val 
        435                 440                 445             


Pro Thr Thr Lys Lys Lys Met Leu Lys Lys Gly Ala Cys Ala Val Glu 
    450                 455                 460                 


Gly Ser Lys Lys Thr Asp Val Glu Glu Arg Pro Arg Thr Thr Leu Ile 
465                 470                 475                 480 


Ile Cys Pro Leu Ser Val Leu Ser Asn Trp Ile Asp Gln Phe Gly Gln 
                485                 490                 495     


His Ile Lys Ser Asp Val His Leu Asn Phe Tyr Val Tyr Tyr Gly Pro 
            500                 505                 510         


Asp Arg Ile Arg Glu Pro Ala Leu Leu Ser Lys Gln Asp Ile Val Leu 
        515                 520                 525             


Thr Thr Tyr Asn Ile Leu Thr His Asp Tyr Gly Thr Lys Gly Asp Ser 
    530                 535                 540                 


Pro Leu His Ser Ile Arg Trp Leu Arg Val Ile Leu Asp Glu Gly His 
545                 550                 555                 560 


Ala Ile Arg Asn Pro Asn Ala Gln Gln Thr Lys Ala Val Leu Asp Leu 
                565                 570                 575     


Glu Ser Glu Arg Arg Trp Val Leu Thr Gly Thr Pro Ile Gln Asn Ser 
            580                 585                 590         


Leu Lys Asp Leu Trp Ser Leu Leu Ser Phe Leu Lys Leu Lys Pro Phe 
        595                 600                 605             


Ile Asp Arg Glu Trp Trp His Arg Thr Ile Gln Arg Pro Val Thr Met 
    610                 615                 620                 


Gly Asp Glu Gly Gly Leu Arg Arg Leu Gln Ser Leu Ile Lys Asn Ile 
625                 630                 635                 640 


Thr Leu Arg Arg Thr Lys Thr Ser Lys Ile Lys Gly Lys Pro Val Leu 
                645                 650                 655     


Glu Leu Pro Glu Arg Lys Val Phe Ile Gln His Ile Thr Leu Ser Asp 
            660                 665                 670         


Glu Glu Arg Lys Ile Tyr Gln Ser Val Lys Asn Glu Gly Arg Ala Thr 
        675                 680                 685             


Ile Gly Arg Tyr Phe Asn Glu Gly Thr Val Leu Ala His Tyr Ala Asp 
    690                 695                 700                 


Val Leu Gly Leu Leu Leu Arg Leu Arg Gln Ile Cys Cys His Thr Tyr 
705                 710                 715                 720 


Leu Leu Thr Asn Ala Val Ser Ser Asn Gly Pro Ser Gly Asn Asp Thr 
                725                 730                 735     


Pro Glu Glu Leu Arg Lys Lys Leu Ile Arg Lys Met Lys Leu Ile Leu 
            740                 745                 750         


Ser Ser Gly Ser Asp Glu Glu Cys Ala Ile Cys Leu Asp Ser Leu Thr 
        755                 760                 765             


Val Pro Val Ile Thr His Cys Ala His Val Phe Cys Lys Pro Cys Ile 
    770                 775                 780                 


Cys Gln Val Ile Gln Asn Glu Gln Pro His Ala Lys Cys Pro Leu Cys 
785                 790                 795                 800 


Arg Asn Asp Ile His Glu Asp Asn Leu Leu Glu Cys Pro Pro Glu Glu 
                805                 810                 815     


Leu Ala Arg Asp Ser Glu Lys Lys Ser Asp Met Glu Trp Thr Ser Ser 
            820                 825                 830         


Ser Lys Ile Asn Ala Leu Met His Ala Leu Thr Asp Leu Arg Lys Lys 
        835                 840                 845             


Asn Pro Asn Ile Lys Ser Leu Val Val Ser Gln Phe Thr Thr Phe Leu 
    850                 855                 860                 


Ser Leu Ile Glu Ile Pro Leu Lys Ala Ser Gly Phe Val Phe Thr Arg 
865                 870                 875                 880 


Leu Asp Gly Ser Met Ala Gln Lys Lys Arg Val Glu Ser Ile Gln Cys 
                885                 890                 895     


Phe Gln Asn Thr Glu Ala Gly Ser Pro Thr Ile Met Leu Leu Ser Leu 
            900                 905                 910         


Lys Ala Gly Gly Val Gly Leu Asn Leu Ser Ala Ala Ser Arg Val Phe 
        915                 920                 925             


Leu Met Asp Pro Ala Trp Asn Pro Ala Ala Glu Asp Gln Cys Phe Asp 
    930                 935                 940                 


Arg Cys His Arg Leu Gly Gln Lys Gln Glu Val Ile Ile Thr Lys Phe 
945                 950                 955                 960 


Ile Val Lys Asp Ser Val Glu Glu Asn Met Leu Lys Ile Gln Asn Lys 
                965                 970                 975     


Lys Arg Glu Leu Ala Ala Gly Ala Phe Gly Thr Lys Lys Pro Asn Ala 
            980                 985                 990         


Asp Glu Met Lys Gln Ala Lys Ile  Asn Glu Ile Arg Thr  Leu Ile Asp 
        995                 1000                 1005             


Leu 
    


<210>  5040
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLX__Homo_sapiens__NP_068777

<400>  5040

Met Phe Ala Ala Gly Leu Ala Pro Phe Tyr Ala Ser Asn Phe Ser Leu 
1               5                   10                  15      


Trp Ser Ala Ala Tyr Cys Ser Ser Ala Gly Pro Gly Gly Cys Ser Phe 
            20                  25                  30          


Pro Leu Asp Pro Ala Ala Val Lys Lys Pro Ser Phe Cys Ile Ala Asp 
        35                  40                  45              


Ile Leu His Ala Gly Val Gly Asp Leu Gly Ala Ala Pro Glu Gly Leu 
    50                  55                  60                  


Ala Gly Ala Ser Ala Ala Ala Leu Thr Ala His Leu Gly Ser Val His 
65                  70                  75                  80  


Pro His Ala Ser Phe Gln Ala Ala Ala Arg Ser Pro Leu Arg Pro Thr 
                85                  90                  95      


Pro Val Val Ala Pro Ser Glu Val Pro Ala Gly Phe Pro Gln Arg Leu 
            100                 105                 110         


Ser Pro Leu Ser Ala Ala Tyr His His His His Pro Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln Gln Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Arg Ala 
    130                 135                 140                 


Gly Ala Leu Gln Pro Pro Ala Ser Gly Thr Arg Val Val Pro Asn Pro 
145                 150                 155                 160 


His His Ser Gly Ser Ala Pro Ala Pro Ser Ser Lys Asp Leu Lys Phe 
                165                 170                 175     


Gly Ile Asp Arg Ile Leu Ser Ala Glu Phe Asp Pro Lys Val Lys Glu 
            180                 185                 190         


Gly Asn Thr Leu Arg Asp Leu Thr Ser Leu Leu Thr Gly Gly Arg Pro 
        195                 200                 205             


Ala Gly Val His Leu Ser Gly Leu Gln Pro Ser Ala Gly Gln Phe Phe 
    210                 215                 220                 


Ala Ser Leu Asp Pro Ile Asn Glu Ala Ser Ala Ile Leu Ser Pro Leu 
225                 230                 235                 240 


Asn Ser Asn Pro Arg Asn Ser Val Gln His Gln Phe Gln Asp Thr Phe 
                245                 250                 255     


Pro Gly Pro Tyr Ala Val Leu Thr Lys Asp Thr Met Pro Gln Thr Tyr 
            260                 265                 270         


Lys Arg Lys Arg Ser Trp Ser Arg Ala Val Phe Ser Asn Leu Gln Arg 
        275                 280                 285             


Lys Gly Leu Glu Lys Arg Phe Glu Ile Gln Lys Tyr Val Thr Lys Pro 
    290                 295                 300                 


Asp Arg Lys Gln Leu Ala Ala Met Leu Gly Leu Thr Asp Ala Gln Val 
305                 310                 315                 320 


Lys Val Trp Phe Gln Asn Arg Arg Met Lys Trp Arg His Ser Lys Glu 
                325                 330                 335     


Ala Gln Ala Gln Lys Asp Lys Asp Lys Glu Ala Gly Glu Lys Pro Ser 
            340                 345                 350         


Gly Gly Ala Pro Ala Ala Asp Gly Glu Gln Asp Glu Arg Ser Pro Ser 
        355                 360                 365             


Arg Ser Glu Gly Glu Ala Glu Ser Glu Ser Ser Asp Ser Glu Ser Leu 
    370                 375                 380                 


Asp Met Ala Pro Ser Asp Thr Glu Arg Thr Glu Gly Ser Glu Arg Ser 
385                 390                 395                 400 


Leu His Gln Thr Thr Val Ile Lys Ala Pro Val Thr Gly Ala Leu Ile 
                405                 410                 415     


Thr Ala Ser Ser Ala Gly Ser Gly Gly Ser Ser Gly Gly Gly Gly Asn 
            420                 425                 430         


Ser Phe Ser Phe Ser Ser Ala Ser Ser Leu Ser Ser Ser Ser Thr Ser 
        435                 440                 445             


Ala Gly Cys Ala Ser Ser Leu Gly Gly Gly Gly Ala Ser Glu Leu Leu 
    450                 455                 460                 


Pro Ala Thr Gln Pro Thr Ala Ser Ser Ala Pro Lys Ser Pro Glu Pro 
465                 470                 475                 480 


Ala Gln Gly Ala Leu Gly Cys Leu 
                485             


<210>  5041
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HM13__Homo_sapiens__NP_110416

<400>  5041

Met Asp Ser Ala Leu Ser Asp Pro His Asn Gly Ser Ala Glu Ala Gly 
1               5                   10                  15      


Gly Pro Thr Asn Ser Thr Thr Arg Pro Pro Ser Thr Pro Glu Gly Ile 
            20                  25                  30          


Ala Leu Ala Tyr Gly Ser Leu Leu Leu Met Ala Leu Leu Pro Ile Phe 
        35                  40                  45              


Phe Gly Ala Leu Arg Ser Val Arg Cys Ala Arg Gly Lys Asn Ala Ser 
    50                  55                  60                  


Asp Met Pro Glu Thr Ile Thr Ser Arg Asp Ala Ala Arg Phe Pro Ile 
65                  70                  75                  80  


Ile Ala Ser Cys Thr Leu Leu Gly Leu Tyr Leu Phe Phe Lys Ile Phe 
                85                  90                  95      


Ser Gln Glu Tyr Ile Asn Leu Leu Leu Ser Met Tyr Phe Phe Val Leu 
            100                 105                 110         


Gly Ile Leu Ala Leu Ser His Thr Ile Ser Pro Phe Met Asn Lys Phe 
        115                 120                 125             


Phe Pro Ala Ser Phe Pro Asn Arg Gln Tyr Gln Leu Leu Phe Thr Gln 
    130                 135                 140                 


Gly Ser Gly Glu Asn Lys Glu Glu Ile Ile Asn Tyr Glu Phe Asp Thr 
145                 150                 155                 160 


Lys Asp Leu Val Cys Leu Gly Leu Ser Ser Ile Val Gly Val Trp Tyr 
                165                 170                 175     


Leu Leu Arg Lys His Trp Ile Ala Asn Asn Leu Phe Gly Leu Ala Phe 
            180                 185                 190         


Ser Leu Asn Gly Val Glu Leu Leu His Leu Asn Asn Val Ser Thr Gly 
        195                 200                 205             


Cys Ile Leu Leu Gly Gly Leu Phe Ile Tyr Asp Val Phe Trp Val Phe 
    210                 215                 220                 


Gly Thr Asn Val Met Val Thr Val Ala Lys Ser Phe Glu Ala Pro Ile 
225                 230                 235                 240 


Lys Leu Val Phe Pro Gln Asp Leu Leu Glu Lys Gly Leu Glu Ala Asn 
                245                 250                 255     


Asn Phe Ala Met Leu Gly Leu Gly Asp Val Val Ile Pro Gly Ile Phe 
            260                 265                 270         


Ile Ala Leu Leu Leu Arg Phe Asp Ile Ser Leu Lys Lys Asn Thr His 
        275                 280                 285             


Thr Tyr Phe Tyr Thr Ser Phe Ala Ala Tyr Ile Phe Gly Leu Gly Leu 
    290                 295                 300                 


Thr Ile Phe Ile Met His Ile Phe Lys His Ala Gln Pro Ala Leu Leu 
305                 310                 315                 320 


Tyr Leu Val Pro Ala Cys Ile Gly Phe Pro Val Leu Val Ala Leu Ala 
                325                 330                 335     


Lys Gly Glu Val Thr Glu Met Phe Ser Tyr Glu Glu Ser Asn Pro Lys 
            340                 345                 350         


Asp Pro Ala Ala Val Thr Glu Ser Lys Glu Gly Thr Glu Ala Ser Ala 
        355                 360                 365             


Ser Lys Gly Leu Glu Lys Lys Glu Lys 
    370                 375         


<210>  5042
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMBOX1__Homo_sapiens__NP_001129198

<400>  5042

Met Leu Ser Ser Phe Pro Val Val Leu Leu Glu Thr Met Ser His Tyr 
1               5                   10                  15      


Thr Asp Glu Pro Arg Phe Thr Ile Glu Gln Ile Asp Leu Leu Gln Arg 
            20                  25                  30          


Leu Arg Arg Thr Gly Met Thr Lys His Glu Ile Leu His Ala Leu Glu 
        35                  40                  45              


Thr Leu Asp Arg Leu Asp Gln Glu His Ser Asp Lys Phe Gly Arg Arg 
    50                  55                  60                  


Ser Ser Tyr Gly Gly Ser Ser Tyr Gly Asn Ser Thr Asn Asn Val Pro 
65                  70                  75                  80  


Ala Ser Ser Ser Thr Ala Thr Ala Ser Thr Gln Thr Gln His Ser Gly 
                85                  90                  95      


Met Ser Pro Ser Pro Ser Asn Ser Tyr Asp Thr Ser Pro Gln Pro Cys 
            100                 105                 110         


Thr Thr Asn Gln Asn Gly Arg Glu Asn Asn Glu Arg Leu Ser Thr Ser 
        115                 120                 125             


Asn Gly Lys Met Ser Pro Thr Arg Tyr His Ala Asn Ser Met Gly Gln 
    130                 135                 140                 


Arg Ser Tyr Ser Phe Glu Ala Ser Glu Glu Asp Leu Asp Val Asp Asp 
145                 150                 155                 160 


Lys Val Glu Glu Leu Met Arg Arg Asp Ser Ser Val Ile Lys Glu Glu 
                165                 170                 175     


Ile Lys Ala Phe Leu Ala Asn Arg Arg Ile Ser Gln Ala Val Val Ala 
            180                 185                 190         


Gln Val Thr Gly Ile Ser Gln Ser Arg Ile Ser His Trp Leu Leu Gln 
        195                 200                 205             


Gln Gly Ser Asp Leu Ser Glu Gln Lys Lys Arg Ala Phe Tyr Arg Trp 
    210                 215                 220                 


Tyr Gln Leu Glu Lys Thr Asn Pro Gly Ala Thr Leu Ser Met Arg Pro 
225                 230                 235                 240 


Ala Pro Ile Pro Ile Glu Asp Pro Glu Trp Arg Gln Thr Pro Pro Pro 
                245                 250                 255     


Val Ser Ala Thr Ser Gly Thr Phe Arg Leu Arg Arg Gly Ser Arg Phe 
            260                 265                 270         


Thr Trp Arg Lys Glu Cys Leu Ala Val Met Glu Ser Tyr Phe Asn Glu 
        275                 280                 285             


Asn Gln Tyr Pro Asp Glu Ala Lys Arg Glu Glu Ile Ala Asn Ala Cys 
    290                 295                 300                 


Asn Ala Val Ile Gln Lys Pro Gly Lys Lys Leu Ser Asp Leu Glu Arg 
305                 310                 315                 320 


Val Thr Ser Leu Lys Val Tyr Asn Trp Phe Ala Asn Arg Arg Lys Glu 
                325                 330                 335     


Ile Lys Arg Arg Ala Asn Ile Glu Ala Ala Ile Leu Glu Ser His Gly 
            340                 345                 350         


Ile Asp Val Gln Ser Pro Gly Gly His Ser Asn Ser Asp Asp Val Asp 
        355                 360                 365             


Gly Asn Asp Tyr Ser Glu Gln Asp Asp Ser Thr Ser His Ser Asp His 
    370                 375                 380                 


Gln Asp Pro Ile Ser Leu Ala Val Glu Met Ala Ala Val Asn His Thr 
385                 390                 395                 400 


Ile Leu Ala Leu Ala Arg Gln Gly Ala Asn Glu Ile Lys Thr Glu Ala 
                405                 410                 415     


Leu Asp Asp Asp 
            420 


<210>  5043
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMBS__Homo_sapiens__NP_000181

<400>  5043

Met Ser Gly Asn Gly Asn Ala Ala Ala Thr Ala Glu Glu Asn Ser Pro 
1               5                   10                  15      


Lys Met Arg Val Ile Arg Val Gly Thr Arg Lys Ser Gln Leu Ala Arg 
            20                  25                  30          


Ile Gln Thr Asp Ser Val Val Ala Thr Leu Lys Ala Ser Tyr Pro Gly 
        35                  40                  45              


Leu Gln Phe Glu Ile Ile Ala Met Ser Thr Thr Gly Asp Lys Ile Leu 
    50                  55                  60                  


Asp Thr Ala Leu Ser Lys Ile Gly Glu Lys Ser Leu Phe Thr Lys Glu 
65                  70                  75                  80  


Leu Glu His Ala Leu Glu Lys Asn Glu Val Asp Leu Val Val His Ser 
                85                  90                  95      


Leu Lys Asp Leu Pro Thr Val Leu Pro Pro Gly Phe Thr Ile Gly Ala 
            100                 105                 110         


Ile Cys Lys Arg Glu Asn Pro His Asp Ala Val Val Phe His Pro Lys 
        115                 120                 125             


Phe Val Gly Lys Thr Leu Glu Thr Leu Pro Glu Lys Ser Val Val Gly 
    130                 135                 140                 


Thr Ser Ser Leu Arg Arg Ala Ala Gln Leu Gln Arg Lys Phe Pro His 
145                 150                 155                 160 


Leu Glu Phe Arg Ser Ile Arg Gly Asn Leu Asn Thr Arg Leu Arg Lys 
                165                 170                 175     


Leu Asp Glu Gln Gln Glu Phe Ser Ala Ile Ile Leu Ala Thr Ala Gly 
            180                 185                 190         


Leu Gln Arg Met Gly Trp His Asn Arg Val Gly Gln Ile Leu His Pro 
        195                 200                 205             


Glu Glu Cys Met Tyr Ala Val Gly Gln Gly Ala Leu Gly Val Glu Val 
    210                 215                 220                 


Arg Ala Lys Asp Gln Asp Ile Leu Asp Leu Val Gly Val Leu His Asp 
225                 230                 235                 240 


Pro Glu Thr Leu Leu Arg Cys Ile Ala Glu Arg Ala Phe Leu Arg His 
                245                 250                 255     


Leu Glu Gly Gly Cys Ser Val Pro Val Ala Val His Thr Ala Met Lys 
            260                 265                 270         


Asp Gly Gln Leu Tyr Leu Thr Gly Gly Val Trp Ser Leu Asp Gly Ser 
        275                 280                 285             


Asp Ser Ile Gln Glu Thr Met Gln Ala Thr Ile His Val Pro Ala Gln 
    290                 295                 300                 


His Glu Asp Gly Pro Glu Asp Asp Pro Gln Leu Val Gly Ile Thr Ala 
305                 310                 315                 320 


Arg Asn Ile Pro Arg Gly Pro Gln Leu Ala Ala Gln Asn Leu Gly Ile 
                325                 330                 335     


Ser Leu Ala Asn Leu Leu Leu Ser Lys Gly Ala Lys Asn Ile Leu Asp 
            340                 345                 350         


Val Ala Arg Gln Leu Asn Asp Ala His 
        355                 360     


<210>  5044
<211>  5635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMCN1__Homo_sapiens__NP_114141

<400>  5044

Met Ile Ser Trp Glu Val Val His Thr Val Phe Leu Phe Ala Leu Leu 
1               5                   10                  15      


Tyr Ser Ser Leu Ala Gln Asp Ala Ser Pro Gln Ser Glu Ile Arg Ala 
            20                  25                  30          


Glu Glu Ile Pro Glu Gly Ala Ser Thr Leu Ala Phe Val Phe Asp Val 
        35                  40                  45              


Thr Gly Ser Met Tyr Asp Asp Leu Val Gln Val Ile Glu Gly Ala Ser 
    50                  55                  60                  


Lys Ile Leu Glu Thr Ser Leu Lys Arg Pro Lys Arg Pro Leu Phe Asn 
65                  70                  75                  80  


Phe Ala Leu Val Pro Phe His Asp Pro Glu Ile Gly Pro Val Thr Ile 
                85                  90                  95      


Thr Thr Asp Pro Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val 
            100                 105                 110         


Gln Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys Ile 
        115                 120                 125             


Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr Asp 
    130                 135                 140                 


Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu Ile 
145                 150                 155                 160 


Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Asp 
                165                 170                 175     


Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser Thr 
            180                 185                 190         


Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu Val 
        195                 200                 205             


Leu Lys Trp Val Glu Glu Ala Val Gln Ala Ser Lys Val His Leu Leu 
    210                 215                 220                 


Ser Thr Asp His Leu Glu Gln Ala Val Asn Thr Trp Arg Ile Pro Phe 
225                 230                 235                 240 


Asp Pro Ser Leu Lys Glu Val Thr Val Ser Leu Ser Gly Pro Ser Pro 
                245                 250                 255     


Met Ile Glu Ile Arg Asn Pro Leu Gly Lys Leu Ile Lys Lys Gly Phe 
            260                 265                 270         


Gly Leu His Glu Leu Leu Asn Ile His Asn Ser Ala Lys Val Val Asn 
        275                 280                 285             


Val Lys Glu Pro Glu Ala Gly Met Trp Thr Val Lys Thr Ser Ser Ser 
    290                 295                 300                 


Gly Arg His Ser Val Arg Ile Thr Gly Leu Ser Thr Ile Asp Phe Arg 
305                 310                 315                 320 


Ala Gly Phe Ser Arg Lys Pro Thr Leu Asp Phe Lys Lys Thr Val Ser 
                325                 330                 335     


Arg Pro Val Gln Gly Ile Pro Thr Tyr Val Leu Leu Asn Thr Ser Gly 
            340                 345                 350         


Ile Ser Thr Pro Ala Arg Ile Asp Leu Leu Glu Leu Leu Ser Ile Ser 
        355                 360                 365             


Gly Ser Ser Leu Lys Thr Ile Pro Val Lys Tyr Tyr Pro His Arg Lys 
    370                 375                 380                 


Pro Tyr Gly Ile Trp Asn Ile Ser Asp Phe Val Pro Pro Asn Glu Ala 
385                 390                 395                 400 


Phe Phe Leu Lys Val Thr Gly Tyr Asp Lys Asp Asp Tyr Leu Phe Gln 
                405                 410                 415     


Arg Val Ser Ser Val Ser Phe Ser Ser Ile Val Pro Asp Ala Pro Lys 
            420                 425                 430         


Val Thr Met Pro Glu Lys Thr Pro Gly Tyr Tyr Leu Gln Pro Gly Gln 
        435                 440                 445             


Ile Pro Cys Ser Val Asp Ser Leu Leu Pro Phe Thr Leu Ser Phe Val 
    450                 455                 460                 


Arg Asn Gly Val Thr Leu Gly Val Asp Gln Tyr Leu Lys Glu Ser Ala 
465                 470                 475                 480 


Ser Val Asn Leu Asp Ile Ala Lys Val Thr Leu Ser Asp Glu Gly Phe 
                485                 490                 495     


Tyr Glu Cys Ile Ala Val Ser Ser Ala Gly Thr Gly Arg Ala Gln Thr 
            500                 505                 510         


Phe Phe Asp Val Ser Glu Pro Pro Pro Val Ile Gln Val Pro Asn Asn 
        515                 520                 525             


Val Thr Val Thr Pro Gly Glu Arg Ala Val Leu Thr Cys Leu Ile Ile 
    530                 535                 540                 


Ser Ala Val Asp Tyr Asn Leu Thr Trp Gln Arg Asn Asp Arg Asp Val 
545                 550                 555                 560 


Arg Leu Ala Glu Pro Ala Arg Ile Arg Thr Leu Ala Asn Leu Ser Leu 
                565                 570                 575     


Glu Leu Lys Ser Val Lys Phe Asn Asp Ala Gly Glu Tyr His Cys Met 
            580                 585                 590         


Val Ser Ser Glu Gly Gly Ser Ser Ala Ala Ser Val Phe Leu Thr Val 
        595                 600                 605             


Gln Glu Pro Pro Lys Val Thr Val Met Pro Lys Asn Gln Ser Phe Thr 
    610                 615                 620                 


Gly Gly Ser Glu Val Ser Ile Met Cys Ser Ala Thr Gly Tyr Pro Lys 
625                 630                 635                 640 


Pro Lys Ile Ala Trp Thr Val Asn Asp Met Phe Ile Val Gly Ser His 
                645                 650                 655     


Arg Tyr Arg Met Thr Ser Asp Gly Thr Leu Phe Ile Lys Asn Ala Ala 
            660                 665                 670         


Pro Lys Asp Ala Gly Ile Tyr Gly Cys Leu Ala Ser Asn Ser Ala Gly 
        675                 680                 685             


Thr Asp Lys Gln Asn Ser Thr Leu Arg Tyr Ile Glu Ala Pro Lys Leu 
    690                 695                 700                 


Met Val Val Gln Ser Glu Leu Leu Val Ala Leu Gly Asp Ile Thr Val 
705                 710                 715                 720 


Met Glu Cys Lys Thr Ser Gly Ile Pro Pro Pro Gln Val Lys Trp Phe 
                725                 730                 735     


Lys Gly Asp Leu Glu Leu Arg Pro Ser Thr Phe Leu Ile Ile Asp Pro 
            740                 745                 750         


Leu Leu Gly Leu Leu Lys Ile Gln Glu Thr Gln Asp Leu Asp Ala Gly 
        755                 760                 765             


Asp Tyr Thr Cys Val Ala Ile Asn Glu Ala Gly Arg Ala Thr Gly Lys 
    770                 775                 780                 


Ile Thr Leu Asp Val Gly Ser Pro Pro Val Phe Ile Gln Glu Pro Ala 
785                 790                 795                 800 


Asp Val Ser Met Glu Ile Gly Ser Asn Val Thr Leu Pro Cys Tyr Val 
                805                 810                 815     


Gln Gly Tyr Pro Glu Pro Thr Ile Lys Trp Arg Arg Leu Asp Asn Met 
            820                 825                 830         


Pro Ile Phe Ser Arg Pro Phe Ser Val Ser Ser Ile Ser Gln Leu Arg 
        835                 840                 845             


Thr Gly Ala Leu Phe Ile Leu Asn Leu Trp Ala Ser Asp Lys Gly Thr 
    850                 855                 860                 


Tyr Ile Cys Glu Ala Glu Asn Gln Phe Gly Lys Ile Gln Ser Glu Thr 
865                 870                 875                 880 


Thr Val Thr Val Thr Gly Leu Val Ala Pro Leu Ile Gly Ile Ser Pro 
                885                 890                 895     


Ser Val Ala Asn Val Ile Glu Gly Gln Gln Leu Thr Leu Pro Cys Thr 
            900                 905                 910         


Leu Leu Ala Gly Asn Pro Ile Pro Glu Arg Arg Trp Ile Lys Asn Ser 
        915                 920                 925             


Ala Met Leu Leu Gln Asn Pro Tyr Ile Thr Val Arg Ser Asp Gly Ser 
    930                 935                 940                 


Leu His Ile Glu Arg Val Gln Leu Gln Asp Gly Gly Glu Tyr Thr Cys 
945                 950                 955                 960 


Val Ala Ser Asn Val Ala Gly Thr Asn Asn Lys Thr Thr Ser Val Val 
                965                 970                 975     


Val His Val Leu Pro Thr Ile Gln His Gly Gln Gln Ile Leu Ser Thr 
            980                 985                 990         


Ile Glu Gly Ile Pro Val Thr Leu  Pro Cys Lys Ala Ser  Gly Asn Pro 
        995                 1000                 1005             


Lys Pro  Ser Val Ile Trp Ser  Lys Lys Gly Glu Leu  Ile Ser Thr 
    1010                 1015                 1020             


Ser Ser  Ala Lys Phe Ser Ala  Gly Ala Asp Gly Ser  Leu Tyr Val 
    1025                 1030                 1035             


Val Ser  Pro Gly Gly Glu Glu  Ser Gly Glu Tyr Val  Cys Thr Ala 
    1040                 1045                 1050             


Thr Asn  Thr Ala Gly Tyr Ala  Lys Arg Lys Val Gln  Leu Thr Val 
    1055                 1060                 1065             


Tyr Val  Arg Pro Arg Val Phe  Gly Asp Gln Arg Gly  Leu Ser Gln 
    1070                 1075                 1080             


Asp Lys  Pro Val Glu Ile Ser  Val Leu Ala Gly Glu  Glu Val Thr 
    1085                 1090                 1095             


Leu Pro  Cys Glu Val Lys Ser  Leu Pro Pro Pro Ile  Ile Thr Trp 
    1100                 1105                 1110             


Ala Lys  Glu Thr Gln Leu Ile  Ser Pro Phe Ser Pro  Arg His Thr 
    1115                 1120                 1125             


Phe Leu  Pro Ser Gly Ser Met  Lys Ile Thr Glu Thr  Arg Thr Ser 
    1130                 1135                 1140             


Asp Ser  Gly Met Tyr Leu Cys  Val Ala Thr Asn Ile  Ala Gly Asn 
    1145                 1150                 1155             


Val Thr  Gln Ala Val Lys Leu  Asn Val His Val Pro  Pro Lys Ile 
    1160                 1165                 1170             


Gln Arg  Gly Pro Lys His Leu  Lys Val Gln Val Gly  Gln Arg Val 
    1175                 1180                 1185             


Asp Ile  Pro Cys Asn Ala Gln  Gly Thr Pro Leu Pro  Val Ile Thr 
    1190                 1195                 1200             


Trp Ser  Lys Gly Gly Ser Thr  Met Leu Val Asp Gly  Glu His His 
    1205                 1210                 1215             


Val Ser  Asn Pro Asp Gly Thr  Leu Ser Ile Asp Gln  Ala Thr Pro 
    1220                 1225                 1230             


Ser Asp  Ala Gly Ile Tyr Thr  Cys Val Ala Thr Asn  Ile Ala Gly 
    1235                 1240                 1245             


Thr Asp  Glu Thr Glu Ile Thr  Leu His Val Gln Glu  Pro Pro Thr 
    1250                 1255                 1260             


Val Glu  Asp Leu Glu Pro Pro  Tyr Asn Thr Thr Phe  Gln Glu Arg 
    1265                 1270                 1275             


Val Ala  Asn Gln Arg Ile Glu  Phe Pro Cys Pro Ala  Lys Gly Thr 
    1280                 1285                 1290             


Pro Lys  Pro Thr Ile Lys Trp  Leu His Asn Gly Arg  Glu Leu Thr 
    1295                 1300                 1305             


Gly Arg  Glu Pro Gly Ile Ser  Ile Leu Glu Asp Gly  Thr Leu Leu 
    1310                 1315                 1320             


Val Ile  Ala Ser Val Thr Pro  Tyr Asp Asn Gly Glu  Tyr Ile Cys 
    1325                 1330                 1335             


Val Ala  Val Asn Glu Ala Gly  Thr Thr Glu Arg Lys  Tyr Asn Leu 
    1340                 1345                 1350             


Lys Val  His Val Pro Pro Val  Ile Lys Asp Lys Glu  Gln Val Thr 
    1355                 1360                 1365             


Asn Val  Ser Val Leu Leu Asn  Gln Leu Thr Asn Leu  Phe Cys Glu 
    1370                 1375                 1380             


Val Glu  Gly Thr Pro Ser Pro  Ile Ile Met Trp Tyr  Lys Asp Asn 
    1385                 1390                 1395             


Val Gln  Val Thr Glu Ser Ser  Thr Ile Gln Thr Val  Asn Asn Gly 
    1400                 1405                 1410             


Lys Ile  Leu Lys Leu Phe Arg  Ala Thr Pro Glu Asp  Ala Gly Arg 
    1415                 1420                 1425             


Tyr Ser  Cys Lys Ala Ile Asn  Ile Ala Gly Thr Ser  Gln Lys Tyr 
    1430                 1435                 1440             


Phe Asn  Ile Asp Val Leu Val  Pro Pro Thr Ile Ile  Gly Thr Asn 
    1445                 1450                 1455             


Phe Pro  Asn Glu Val Ser Val  Val Leu Asn Arg Asp  Val Ala Leu 
    1460                 1465                 1470             


Glu Cys  Gln Val Lys Gly Thr  Pro Phe Pro Asp Ile  His Trp Phe 
    1475                 1480                 1485             


Lys Asp  Gly Lys Pro Leu Phe  Leu Gly Asp Pro Asn  Val Glu Leu 
    1490                 1495                 1500             


Leu Asp  Arg Gly Gln Val Leu  His Leu Lys Asn Ala  Arg Arg Asn 
    1505                 1510                 1515             


Asp Lys  Gly Arg Tyr Gln Cys  Thr Val Ser Asn Ala  Ala Gly Lys 
    1520                 1525                 1530             


Gln Ala  Lys Asp Ile Lys Leu  Thr Ile Tyr Ile Pro  Pro Ser Ile 
    1535                 1540                 1545             


Lys Gly  Gly Asn Val Thr Thr  Asp Ile Ser Val Leu  Ile Asn Ser 
    1550                 1555                 1560             


Leu Ile  Lys Leu Glu Cys Glu  Thr Arg Gly Leu Pro  Met Pro Ala 
    1565                 1570                 1575             


Ile Thr  Trp Tyr Lys Asp Gly  Gln Pro Ile Met Ser  Ser Ser Gln 
    1580                 1585                 1590             


Ala Leu  Tyr Ile Asp Lys Gly  Gln Tyr Leu His Ile  Pro Arg Ala 
    1595                 1600                 1605             


Gln Val  Ser Asp Ser Ala Thr  Tyr Thr Cys His Val  Ala Asn Val 
    1610                 1615                 1620             


Ala Gly  Thr Ala Glu Lys Ser  Phe His Val Asp Val  Tyr Val Pro 
    1625                 1630                 1635             


Pro Met  Ile Glu Gly Asn Leu  Ala Thr Pro Leu Asn  Lys Gln Val 
    1640                 1645                 1650             


Val Ile  Ala His Ser Leu Thr  Leu Glu Cys Lys Ala  Ala Gly Asn 
    1655                 1660                 1665             


Pro Ser  Pro Ile Leu Thr Trp  Leu Lys Asp Gly Val  Pro Val Lys 
    1670                 1675                 1680             


Ala Asn  Asp Asn Ile Arg Ile  Glu Ala Gly Gly Lys  Lys Leu Glu 
    1685                 1690                 1695             


Ile Met  Ser Ala Gln Glu Ile  Asp Arg Gly Gln Tyr  Ile Cys Val 
    1700                 1705                 1710             


Ala Thr  Ser Val Ala Gly Glu  Lys Glu Ile Lys Tyr  Glu Val Asp 
    1715                 1720                 1725             


Val Leu  Val Pro Pro Ala Ile  Glu Gly Gly Asp Glu  Thr Ser Tyr 
    1730                 1735                 1740             


Phe Ile  Val Met Val Asn Asn  Leu Leu Glu Leu Asp  Cys His Val 
    1745                 1750                 1755             


Thr Gly  Ser Pro Pro Pro Thr  Ile Met Trp Leu Lys  Asp Gly Gln 
    1760                 1765                 1770             


Leu Ile  Asp Glu Arg Asp Gly  Phe Lys Ile Leu Leu  Asn Gly Arg 
    1775                 1780                 1785             


Lys Leu  Val Ile Ala Gln Ala  Gln Val Ser Asn Thr  Gly Leu Tyr 
    1790                 1795                 1800             


Arg Cys  Met Ala Ala Asn Thr  Ala Gly Asp His Lys  Lys Glu Phe 
    1805                 1810                 1815             


Glu Val  Thr Val His Val Pro  Pro Thr Ile Lys Ser  Ser Gly Leu 
    1820                 1825                 1830             


Ser Glu  Arg Val Val Val Lys  Tyr Lys Pro Val Ala  Leu Gln Cys 
    1835                 1840                 1845             


Ile Ala  Asn Gly Ile Pro Asn  Pro Ser Ile Thr Trp  Leu Lys Asp 
    1850                 1855                 1860             


Asp Gln  Pro Val Asn Thr Ala  Gln Gly Asn Leu Lys  Ile Gln Ser 
    1865                 1870                 1875             


Ser Gly  Arg Val Leu Gln Ile  Ala Lys Thr Leu Leu  Glu Asp Ala 
    1880                 1885                 1890             


Gly Arg  Tyr Thr Cys Val Ala  Thr Asn Ala Ala Gly  Glu Thr Gln 
    1895                 1900                 1905             


Gln His  Ile Gln Leu His Val  His Glu Pro Pro Ser  Leu Glu Asp 
    1910                 1915                 1920             


Ala Gly  Lys Met Leu Asn Glu  Thr Val Leu Val Ser  Asn Pro Val 
    1925                 1930                 1935             


Gln Leu  Glu Cys Lys Ala Ala  Gly Asn Pro Val Pro  Val Ile Thr 
    1940                 1945                 1950             


Trp Tyr  Lys Asp Asn Arg Leu  Leu Ser Gly Ser Thr  Ser Met Thr 
    1955                 1960                 1965             


Phe Leu  Asn Arg Gly Gln Ile  Ile Asp Ile Glu Ser  Ala Gln Ile 
    1970                 1975                 1980             


Ser Asp  Ala Gly Ile Tyr Lys  Cys Val Ala Ile Asn  Ser Ala Gly 
    1985                 1990                 1995             


Ala Thr  Glu Leu Phe Tyr Ser  Leu Gln Val His Val  Ala Pro Ser 
    2000                 2005                 2010             


Ile Ser  Gly Ser Asn Asn Met  Val Ala Val Val Val  Asn Asn Pro 
    2015                 2020                 2025             


Val Arg  Leu Glu Cys Glu Ala  Arg Gly Ile Pro Ala  Pro Ser Leu 
    2030                 2035                 2040             


Thr Trp  Leu Lys Asp Gly Ser  Pro Val Ser Ser Phe  Ser Asn Gly 
    2045                 2050                 2055             


Leu Gln  Val Leu Ser Gly Gly  Arg Ile Leu Ala Leu  Thr Ser Ala 
    2060                 2065                 2070             


Gln Ile  Ser Asp Thr Gly Arg  Tyr Thr Cys Val Ala  Val Asn Ala 
    2075                 2080                 2085             


Ala Gly  Glu Lys Gln Arg Asp  Ile Asp Leu Arg Val  Tyr Val Pro 
    2090                 2095                 2100             


Pro Asn  Ile Met Gly Glu Glu  Gln Asn Val Ser Val  Leu Ile Ser 
    2105                 2110                 2115             


Gln Ala  Val Glu Leu Leu Cys  Gln Ser Asp Ala Ile  Pro Pro Pro 
    2120                 2125                 2130             


Thr Leu  Thr Trp Leu Lys Asp  Gly His Pro Leu Leu  Lys Lys Pro 
    2135                 2140                 2145             


Gly Leu  Ser Ile Ser Glu Asn  Arg Ser Val Leu Lys  Ile Glu Asp 
    2150                 2155                 2160             


Ala Gln  Val Gln Asp Thr Gly  Arg Tyr Thr Cys Glu  Ala Thr Asn 
    2165                 2170                 2175             


Val Ala  Gly Lys Thr Glu Lys  Asn Tyr Asn Val Asn  Ile Trp Val 
    2180                 2185                 2190             


Pro Pro  Asn Ile Gly Gly Ser  Asp Glu Leu Thr Gln  Leu Thr Val 
    2195                 2200                 2205             


Ile Glu  Gly Asn Leu Ile Ser  Leu Leu Cys Glu Ser  Ser Gly Ile 
    2210                 2215                 2220             


Pro Pro  Pro Asn Leu Ile Trp  Lys Lys Lys Gly Ser  Pro Val Leu 
    2225                 2230                 2235             


Thr Asp  Ser Met Gly Arg Val  Arg Ile Leu Ser Gly  Gly Arg Gln 
    2240                 2245                 2250             


Leu Gln  Ile Ser Ile Ala Glu  Lys Ser Asp Ala Ala  Leu Tyr Ser 
    2255                 2260                 2265             


Cys Val  Ala Ser Asn Val Ala  Gly Thr Ala Lys Lys  Glu Tyr Asn 
    2270                 2275                 2280             


Leu Gln  Val Tyr Ile Arg Pro  Thr Ile Thr Asn Ser  Gly Ser His 
    2285                 2290                 2295             


Pro Thr  Glu Ile Ile Val Thr  Arg Gly Lys Ser Ile  Ser Leu Glu 
    2300                 2305                 2310             


Cys Glu  Val Gln Gly Ile Pro  Pro Pro Thr Val Thr  Trp Met Lys 
    2315                 2320                 2325             


Asp Gly  His Pro Leu Ile Lys  Ala Lys Gly Val Glu  Ile Leu Asp 
    2330                 2335                 2340             


Glu Gly  His Ile Leu Gln Leu  Lys Asn Ile His Val  Ser Asp Thr 
    2345                 2350                 2355             


Gly Arg  Tyr Val Cys Val Ala  Val Asn Val Ala Gly  Met Thr Asp 
    2360                 2365                 2370             


Lys Lys  Tyr Asp Leu Ser Val  His Ala Pro Pro Ser  Ile Ile Gly 
    2375                 2380                 2385             


Asn His  Arg Ser Pro Glu Asn  Ile Ser Val Val Glu  Lys Asn Ser 
    2390                 2395                 2400             


Val Ser  Leu Thr Cys Glu Ala  Ser Gly Ile Pro Leu  Pro Ser Ile 
    2405                 2410                 2415             


Thr Trp  Phe Lys Asp Gly Trp  Pro Val Ser Leu Ser  Asn Ser Val 
    2420                 2425                 2430             


Arg Ile  Leu Ser Gly Gly Arg  Met Leu Arg Leu Met  Gln Thr Thr 
    2435                 2440                 2445             


Met Glu  Asp Ala Gly Gln Tyr  Thr Cys Val Val Arg  Asn Ala Ala 
    2450                 2455                 2460             


Gly Glu  Glu Arg Lys Ile Phe  Gly Leu Ser Val Leu  Val Pro Pro 
    2465                 2470                 2475             


His Ile  Val Gly Glu Asn Thr  Leu Glu Asp Val Lys  Val Lys Glu 
    2480                 2485                 2490             


Lys Gln  Ser Val Thr Leu Thr  Cys Glu Val Thr Gly  Asn Pro Val 
    2495                 2500                 2505             


Pro Glu  Ile Thr Trp His Lys  Asp Gly Gln Pro Leu  Gln Glu Asp 
    2510                 2515                 2520             


Glu Ala  His His Ile Ile Ser  Gly Gly Arg Phe Leu  Gln Ile Thr 
    2525                 2530                 2535             


Asn Val  Gln Val Pro His Thr  Gly Arg Tyr Thr Cys  Leu Ala Ser 
    2540                 2545                 2550             


Ser Pro  Ala Gly His Lys Ser  Arg Ser Phe Ser Leu  Asn Val Phe 
    2555                 2560                 2565             


Val Ser  Pro Thr Ile Ala Gly  Val Gly Ser Asp Gly  Asn Pro Glu 
    2570                 2575                 2580             


Asp Val  Thr Val Ile Leu Asn  Ser Pro Thr Ser Leu  Val Cys Glu 
    2585                 2590                 2595             


Ala Tyr  Ser Tyr Pro Pro Ala  Thr Ile Thr Trp Phe  Lys Asp Gly 
    2600                 2605                 2610             


Thr Pro  Leu Glu Ser Asn Arg  Asn Ile Arg Ile Leu  Pro Gly Gly 
    2615                 2620                 2625             


Arg Thr  Leu Gln Ile Leu Asn  Ala Gln Glu Asp Asn  Ala Gly Arg 
    2630                 2635                 2640             


Tyr Ser  Cys Val Ala Thr Asn  Glu Ala Gly Glu Met  Ile Lys His 
    2645                 2650                 2655             


Tyr Glu  Val Lys Val Tyr Ile  Pro Pro Ile Ile Asn  Lys Gly Asp 
    2660                 2665                 2670             


Leu Trp  Gly Pro Gly Leu Ser  Pro Lys Glu Val Lys  Ile Lys Val 
    2675                 2680                 2685             


Asn Asn  Thr Leu Thr Leu Glu  Cys Glu Ala Tyr Ala  Ile Pro Ser 
    2690                 2695                 2700             


Ala Ser  Leu Ser Trp Tyr Lys  Asp Gly Gln Pro Leu  Lys Ser Asp 
    2705                 2710                 2715             


Asp His  Val Asn Ile Ala Ala  Asn Gly His Thr Leu  Gln Ile Lys 
    2720                 2725                 2730             


Glu Ala  Gln Ile Ser Asp Thr  Gly Arg Tyr Thr Cys  Val Ala Ser 
    2735                 2740                 2745             


Asn Ile  Ala Gly Glu Asp Glu  Leu Asp Phe Asp Val  Asn Ile Gln 
    2750                 2755                 2760             


Val Pro  Pro Ser Phe Gln Lys  Leu Trp Glu Ile Gly  Asn Met Leu 
    2765                 2770                 2775             


Asp Thr  Gly Arg Asn Gly Glu  Ala Lys Asp Val Ile  Ile Asn Asn 
    2780                 2785                 2790             


Pro Ile  Ser Leu Tyr Cys Glu  Thr Asn Ala Ala Pro  Pro Pro Thr 
    2795                 2800                 2805             


Leu Thr  Trp Tyr Lys Asp Gly  His Pro Leu Thr Ser  Ser Asp Lys 
    2810                 2815                 2820             


Val Leu  Ile Leu Pro Gly Gly  Arg Val Leu Gln Ile  Pro Arg Ala 
    2825                 2830                 2835             


Lys Val  Glu Asp Ala Gly Arg  Tyr Thr Cys Val Ala  Val Asn Glu 
    2840                 2845                 2850             


Ala Gly  Glu Asp Ser Leu Gln  Tyr Asp Val Arg Val  Leu Val Pro 
    2855                 2860                 2865             


Pro Ile  Ile Lys Gly Ala Asn  Ser Asp Leu Pro Glu  Glu Val Thr 
    2870                 2875                 2880             


Val Leu  Val Asn Lys Ser Ala  Leu Ile Glu Cys Leu  Ser Ser Gly 
    2885                 2890                 2895             


Ser Pro  Ala Pro Arg Asn Ser  Trp Gln Lys Asp Gly  Gln Pro Leu 
    2900                 2905                 2910             


Leu Glu  Asp Asp His His Lys  Phe Leu Ser Asn Gly  Arg Ile Leu 
    2915                 2920                 2925             


Gln Ile  Leu Asn Thr Gln Ile  Thr Asp Ile Gly Arg  Tyr Val Cys 
    2930                 2935                 2940             


Val Ala  Glu Asn Thr Ala Gly  Ser Ala Lys Lys Tyr  Phe Asn Leu 
    2945                 2950                 2955             


Asn Val  His Val Pro Pro Ser  Val Ile Gly Pro Lys  Ser Glu Asn 
    2960                 2965                 2970             


Leu Thr  Val Val Val Asn Asn  Phe Ile Ser Leu Thr  Cys Glu Val 
    2975                 2980                 2985             


Ser Gly  Phe Pro Pro Pro Asp  Leu Ser Trp Leu Lys  Asn Glu Gln 
    2990                 2995                 3000             


Pro Ile  Lys Leu Asn Thr Asn  Thr Leu Ile Val Pro  Gly Gly Arg 
    3005                 3010                 3015             


Thr Leu  Gln Ile Ile Arg Ala  Lys Val Ser Asp Gly  Gly Glu Tyr 
    3020                 3025                 3030             


Thr Cys  Ile Ala Ile Asn Gln  Ala Gly Glu Ser Lys  Lys Lys Phe 
    3035                 3040                 3045             


Ser Leu  Thr Val Tyr Val Pro  Pro Ser Ile Lys Asp  His Asp Ser 
    3050                 3055                 3060             


Glu Ser  Leu Ser Val Val Asn  Val Arg Glu Gly Thr  Ser Val Ser 
    3065                 3070                 3075             


Leu Glu  Cys Glu Ser Asn Ala  Val Pro Pro Pro Val  Ile Thr Trp 
    3080                 3085                 3090             


Tyr Lys  Asn Gly Arg Met Ile  Thr Glu Ser Thr His  Val Glu Ile 
    3095                 3100                 3105             


Leu Ala  Asp Gly Gln Met Leu  His Ile Lys Lys Ala  Glu Val Ser 
    3110                 3115                 3120             


Asp Thr  Gly Gln Tyr Val Cys  Arg Ala Ile Asn Val  Ala Gly Arg 
    3125                 3130                 3135             


Asp Asp  Lys Asn Phe His Leu  Asn Val Tyr Val Pro  Pro Ser Ile 
    3140                 3145                 3150             


Glu Gly  Pro Glu Arg Glu Val  Ile Val Glu Thr Ile  Ser Asn Pro 
    3155                 3160                 3165             


Val Thr  Leu Thr Cys Asp Ala  Thr Gly Ile Pro Pro  Pro Thr Ile 
    3170                 3175                 3180             


Ala Trp  Leu Lys Asn His Lys  Arg Ile Glu Asn Ser  Asp Ser Leu 
    3185                 3190                 3195             


Glu Val  Arg Ile Leu Ser Gly  Gly Ser Lys Leu Gln  Ile Ala Arg 
    3200                 3205                 3210             


Ser Gln  His Ser Asp Ser Gly  Asn Tyr Thr Cys Ile  Ala Ser Asn 
    3215                 3220                 3225             


Met Glu  Gly Lys Ala Gln Lys  Tyr Tyr Phe Leu Ser  Ile Gln Val 
    3230                 3235                 3240             


Pro Pro  Ser Val Ala Gly Ala  Glu Ile Pro Ser Asp  Val Ser Val 
    3245                 3250                 3255             


Leu Leu  Gly Glu Asn Val Glu  Leu Val Cys Asn Ala  Asn Gly Ile 
    3260                 3265                 3270             


Pro Thr  Pro Leu Ile Gln Trp  Leu Lys Asp Gly Lys  Pro Ile Ala 
    3275                 3280                 3285             


Ser Gly  Glu Thr Glu Arg Ile  Arg Val Ser Ala Asn  Gly Ser Thr 
    3290                 3295                 3300             


Leu Asn  Ile Tyr Gly Ala Leu  Thr Ser Asp Thr Gly  Lys Tyr Thr 
    3305                 3310                 3315             


Cys Val  Ala Thr Asn Pro Ala  Gly Glu Glu Asp Arg  Ile Phe Asn 
    3320                 3325                 3330             


Leu Asn  Val Tyr Val Thr Pro  Thr Ile Arg Gly Asn  Lys Asp Glu 
    3335                 3340                 3345             


Ala Glu  Lys Leu Met Thr Leu  Val Asp Thr Ser Ile  Asn Ile Glu 
    3350                 3355                 3360             


Cys Arg  Ala Thr Gly Thr Pro  Pro Pro Gln Ile Asn  Trp Leu Lys 
    3365                 3370                 3375             


Asn Gly  Leu Pro Leu Pro Leu  Ser Ser His Ile Arg  Leu Leu Ala 
    3380                 3385                 3390             


Ala Gly  Gln Val Ile Arg Ile  Val Arg Ala Gln Val  Ser Asp Val 
    3395                 3400                 3405             


Ala Val  Tyr Thr Cys Val Ala  Ser Asn Arg Ala Gly  Val Asp Asn 
    3410                 3415                 3420             


Lys His  Tyr Asn Leu Gln Val  Phe Ala Pro Pro Asn  Met Asp Asn 
    3425                 3430                 3435             


Ser Met  Gly Thr Glu Glu Ile  Thr Val Leu Lys Gly  Ser Ser Thr 
    3440                 3445                 3450             


Ser Met  Ala Cys Ile Thr Asp  Gly Thr Pro Ala Pro  Ser Met Ala 
    3455                 3460                 3465             


Trp Leu  Arg Asp Gly Gln Pro  Leu Gly Leu Asp Ala  His Leu Thr 
    3470                 3475                 3480             


Val Ser  Thr His Gly Met Val  Leu Gln Leu Leu Lys  Ala Glu Thr 
    3485                 3490                 3495             


Glu Asp  Ser Gly Lys Tyr Thr  Cys Ile Ala Ser Asn  Glu Ala Gly 
    3500                 3505                 3510             


Glu Val  Ser Lys His Phe Ile  Leu Lys Val Leu Glu  Pro Pro His 
    3515                 3520                 3525             


Ile Asn  Gly Ser Glu Glu His  Glu Glu Ile Ser Val  Ile Val Asn 
    3530                 3535                 3540             


Asn Pro  Leu Glu Leu Thr Cys  Ile Ala Ser Gly Ile  Pro Ala Pro 
    3545                 3550                 3555             


Lys Met  Thr Trp Met Lys Asp  Gly Arg Pro Leu Pro  Gln Thr Asp 
    3560                 3565                 3570             


Gln Val  Gln Thr Leu Gly Gly  Gly Glu Val Leu Arg  Ile Ser Thr 
    3575                 3580                 3585             


Ala Gln  Val Glu Asp Thr Gly  Arg Tyr Thr Cys Leu  Ala Ser Ser 
    3590                 3595                 3600             


Pro Ala  Gly Asp Asp Asp Lys  Glu Tyr Leu Val Arg  Val His Val 
    3605                 3610                 3615             


Pro Pro  Asn Ile Ala Gly Thr  Asp Glu Pro Arg Asp  Ile Thr Val 
    3620                 3625                 3630             


Leu Arg  Asn Arg Gln Val Thr  Leu Glu Cys Lys Ser  Asp Ala Val 
    3635                 3640                 3645             


Pro Pro  Pro Val Ile Thr Trp  Leu Arg Asn Gly Glu  Arg Leu Gln 
    3650                 3655                 3660             


Ala Thr  Pro Arg Val Arg Ile  Leu Ser Gly Gly Arg  Tyr Leu Gln 
    3665                 3670                 3675             


Ile Asn  Asn Ala Asp Leu Gly  Asp Thr Ala Asn Tyr  Thr Cys Val 
    3680                 3685                 3690             


Ala Ser  Asn Ile Ala Gly Lys  Thr Thr Arg Glu Phe  Ile Leu Thr 
    3695                 3700                 3705             


Val Asn  Val Pro Pro Asn Ile  Lys Gly Gly Pro Gln  Ser Leu Val 
    3710                 3715                 3720             


Ile Leu  Leu Asn Lys Ser Thr  Val Leu Glu Cys Ile  Ala Glu Gly 
    3725                 3730                 3735             


Val Pro  Thr Pro Arg Ile Thr  Trp Arg Lys Asp Gly  Ala Val Leu 
    3740                 3745                 3750             


Ala Gly  Asn His Ala Arg Tyr  Ser Ile Leu Glu Asn  Gly Phe Leu 
    3755                 3760                 3765             


His Ile  Gln Ser Ala His Val  Thr Asp Thr Gly Arg  Tyr Leu Cys 
    3770                 3775                 3780             


Met Ala  Thr Asn Ala Ala Gly  Thr Asp Arg Arg Arg  Ile Asp Leu 
    3785                 3790                 3795             


Gln Val  His Val Pro Pro Ser  Ile Ala Pro Gly Pro  Thr Asn Met 
    3800                 3805                 3810             


Thr Val  Ile Val Asn Val Gln  Thr Thr Leu Ala Cys  Glu Ala Thr 
    3815                 3820                 3825             


Gly Ile  Pro Lys Pro Ser Ile  Asn Trp Arg Lys Asn  Gly His Leu 
    3830                 3835                 3840             


Leu Asn  Val Asp Gln Asn Gln  Asn Ser Tyr Arg Leu  Leu Ser Ser 
    3845                 3850                 3855             


Gly Ser  Leu Val Ile Ile Ser  Pro Ser Val Asp Asp  Thr Ala Thr 
    3860                 3865                 3870             


Tyr Glu  Cys Thr Val Thr Asn  Gly Ala Gly Asp Asp  Lys Arg Thr 
    3875                 3880                 3885             


Val Asp  Leu Thr Val Gln Val  Pro Pro Ser Ile Ala  Asp Glu Pro 
    3890                 3895                 3900             


Thr Asp  Phe Leu Val Thr Lys  His Ala Pro Ala Val  Ile Thr Cys 
    3905                 3910                 3915             


Thr Ala  Ser Gly Val Pro Phe  Pro Ser Ile His Trp  Thr Lys Asn 
    3920                 3925                 3930             


Gly Ile  Arg Leu Leu Pro Arg  Gly Asp Gly Tyr Arg  Ile Leu Ser 
    3935                 3940                 3945             


Ser Gly  Ala Ile Glu Ile Leu  Ala Thr Gln Leu Asn  His Ala Gly 
    3950                 3955                 3960             


Arg Tyr  Thr Cys Val Ala Arg  Asn Ala Ala Gly Ser  Ala His Arg 
    3965                 3970                 3975             


His Val  Thr Leu His Val His  Glu Pro Pro Val Ile  Gln Pro Gln 
    3980                 3985                 3990             


Pro Ser  Glu Leu His Val Ile  Leu Asn Asn Pro Ile  Leu Leu Pro 
    3995                 4000                 4005             


Cys Glu  Ala Thr Gly Thr Pro  Ser Pro Phe Ile Thr  Trp Gln Lys 
    4010                 4015                 4020             


Glu Gly  Ile Asn Val Asn Thr  Ser Gly Arg Asn His  Ala Val Leu 
    4025                 4030                 4035             


Pro Ser  Gly Gly Leu Gln Ile  Ser Arg Ala Val Arg  Glu Asp Ala 
    4040                 4045                 4050             


Gly Thr  Tyr Met Cys Val Ala  Gln Asn Pro Ala Gly  Thr Ala Leu 
    4055                 4060                 4065             


Gly Lys  Ile Lys Leu Asn Val  Gln Val Pro Pro Val  Ile Ser Pro 
    4070                 4075                 4080             


His Leu  Lys Glu Tyr Val Ile  Ala Val Asp Lys Pro  Ile Thr Leu 
    4085                 4090                 4095             


Ser Cys  Glu Ala Asp Gly Leu  Pro Pro Pro Asp Ile  Thr Trp His 
    4100                 4105                 4110             


Lys Asp  Gly Arg Ala Ile Val  Glu Ser Ile Arg Gln  Arg Val Leu 
    4115                 4120                 4125             


Ser Ser  Gly Ser Leu Gln Ile  Ala Phe Val Gln Pro  Gly Asp Ala 
    4130                 4135                 4140             


Gly His  Tyr Thr Cys Met Ala  Ala Asn Val Ala Gly  Ser Ser Ser 
    4145                 4150                 4155             


Thr Ser  Thr Lys Leu Thr Val  His Val Pro Pro Arg  Ile Arg Ser 
    4160                 4165                 4170             


Thr Glu  Gly His Tyr Thr Val  Asn Glu Asn Ser Gln  Ala Ile Leu 
    4175                 4180                 4185             


Pro Cys  Val Ala Asp Gly Ile  Pro Thr Pro Ala Ile  Asn Trp Lys 
    4190                 4195                 4200             


Lys Asp  Asn Val Leu Leu Ala  Asn Leu Leu Gly Lys  Tyr Thr Ala 
    4205                 4210                 4215             


Glu Pro  Tyr Gly Glu Leu Ile  Leu Glu Asn Val Val  Leu Glu Asp 
    4220                 4225                 4230             


Ser Gly  Phe Tyr Thr Cys Val  Ala Asn Asn Ala Ala  Gly Glu Asp 
    4235                 4240                 4245             


Thr His  Thr Val Ser Leu Thr  Val His Val Leu Pro  Thr Phe Thr 
    4250                 4255                 4260             


Glu Leu  Pro Gly Asp Val Ser  Leu Asn Lys Gly Glu  Gln Leu Arg 
    4265                 4270                 4275             


Leu Ser  Cys Lys Ala Thr Gly  Ile Pro Leu Pro Lys  Leu Thr Trp 
    4280                 4285                 4290             


Thr Phe  Asn Asn Asn Ile Ile  Pro Ala His Phe Asp  Ser Val Asn 
    4295                 4300                 4305             


Gly His  Ser Glu Leu Val Ile  Glu Arg Val Ser Lys  Glu Asp Ser 
    4310                 4315                 4320             


Gly Thr  Tyr Val Cys Thr Ala  Glu Asn Ser Val Gly  Phe Val Lys 
    4325                 4330                 4335             


Ala Ile  Gly Phe Val Tyr Val  Lys Glu Pro Pro Val  Phe Lys Gly 
    4340                 4345                 4350             


Asp Tyr  Pro Ser Asn Trp Ile  Glu Pro Leu Gly Gly  Asn Ala Ile 
    4355                 4360                 4365             


Leu Asn  Cys Glu Val Lys Gly  Asp Pro Thr Pro Thr  Ile Gln Trp 
    4370                 4375                 4380             


Asn Arg  Lys Gly Val Asp Ile  Glu Ile Ser His Arg  Ile Arg Gln 
    4385                 4390                 4395             


Leu Gly  Asn Gly Ser Leu Ala  Ile Tyr Gly Thr Val  Asn Glu Asp 
    4400                 4405                 4410             


Ala Gly  Asp Tyr Thr Cys Val  Ala Thr Asn Glu Ala  Gly Val Val 
    4415                 4420                 4425             


Glu Arg  Ser Met Ser Leu Thr  Leu Gln Ser Pro Pro  Ile Ile Thr 
    4430                 4435                 4440             


Leu Glu  Pro Val Glu Thr Val  Ile Asn Ala Gly Gly  Lys Ile Ile 
    4445                 4450                 4455             


Leu Asn  Cys Gln Ala Thr Gly  Glu Pro Gln Pro Thr  Ile Thr Trp 
    4460                 4465                 4470             


Ser Arg  Gln Gly His Ser Ile  Ser Trp Asp Asp Arg  Val Asn Val 
    4475                 4480                 4485             


Leu Ser  Asn Asn Ser Leu Tyr  Ile Ala Asp Ala Gln  Lys Glu Asp 
    4490                 4495                 4500             


Thr Ser  Glu Phe Glu Cys Val  Ala Arg Asn Leu Met  Gly Ser Val 
    4505                 4510                 4515             


Leu Val  Arg Val Pro Val Ile  Val Gln Val His Gly  Gly Phe Ser 
    4520                 4525                 4530             


Gln Trp  Ser Ala Trp Arg Ala  Cys Ser Val Thr Cys  Gly Lys Gly 
    4535                 4540                 4545             


Ile Gln  Lys Arg Ser Arg Leu  Cys Asn Gln Pro Leu  Pro Ala Asn 
    4550                 4555                 4560             


Gly Gly  Lys Pro Cys Gln Gly  Ser Asp Leu Glu Met  Arg Asn Cys 
    4565                 4570                 4575             


Gln Asn  Lys Pro Cys Pro Val  Asp Gly Ser Trp Ser  Glu Trp Ser 
    4580                 4585                 4590             


Leu Trp  Glu Glu Cys Thr Arg  Ser Cys Gly Arg Gly  Asn Gln Thr 
    4595                 4600                 4605             


Arg Thr  Arg Thr Cys Asn Asn  Pro Ser Val Gln His  Gly Gly Arg 
    4610                 4615                 4620             


Pro Cys  Glu Gly Asn Ala Val  Glu Ile Ile Met Cys  Asn Ile Arg 
    4625                 4630                 4635             


Pro Cys  Pro Val His Gly Ala  Trp Ser Ala Trp Gln  Pro Trp Gly 
    4640                 4645                 4650             


Thr Cys  Ser Glu Ser Cys Gly  Lys Gly Thr Gln Thr  Arg Ala Arg 
    4655                 4660                 4665             


Leu Cys  Asn Asn Pro Pro Pro  Ala Phe Gly Gly Ser  Tyr Cys Asp 
    4670                 4675                 4680             


Gly Ala  Glu Thr Gln Met Gln  Val Cys Asn Glu Arg  Asn Cys Pro 
    4685                 4690                 4695             


Ile His  Gly Lys Trp Ala Thr  Trp Ala Ser Trp Ser  Ala Cys Ser 
    4700                 4705                 4710             


Val Ser  Cys Gly Gly Gly Ala  Arg Gln Arg Thr Arg  Gly Cys Ser 
    4715                 4720                 4725             


Asp Pro  Val Pro Gln Tyr Gly  Gly Arg Lys Cys Glu  Gly Ser Asp 
    4730                 4735                 4740             


Val Gln  Ser Asp Phe Cys Asn  Ser Asp Pro Cys Pro  Thr His Gly 
    4745                 4750                 4755             


Asn Trp  Ser Pro Trp Ser Gly  Trp Gly Thr Cys Ser  Arg Thr Cys 
    4760                 4765                 4770             


Asn Gly  Gly Gln Met Arg Arg  Tyr Arg Thr Cys Asp  Asn Pro Pro 
    4775                 4780                 4785             


Pro Ser  Asn Gly Gly Arg Ala  Cys Gly Gly Pro Asp  Ser Gln Ile 
    4790                 4795                 4800             


Gln Arg  Cys Asn Thr Asp Met  Cys Pro Val Asp Gly  Ser Trp Gly 
    4805                 4810                 4815             


Ser Trp  His Ser Trp Ser Gln  Cys Ser Ala Ser Cys  Gly Gly Gly 
    4820                 4825                 4830             


Glu Lys  Thr Arg Lys Arg Leu  Cys Asp His Pro Val  Pro Val Lys 
    4835                 4840                 4845             


Gly Gly  Arg Pro Cys Pro Gly  Asp Thr Thr Gln Val  Thr Arg Cys 
    4850                 4855                 4860             


Asn Val  Gln Ala Cys Pro Gly  Gly Pro Gln Arg Ala  Arg Gly Ser 
    4865                 4870                 4875             


Val Ile  Gly Asn Ile Asn Asp  Val Glu Phe Gly Ile  Ala Phe Leu 
    4880                 4885                 4890             


Asn Ala  Thr Ile Thr Asp Ser  Pro Asn Ser Asp Thr  Arg Ile Ile 
    4895                 4900                 4905             


Arg Ala  Lys Ile Thr Asn Val  Pro Arg Ser Leu Gly  Ser Ala Met 
    4910                 4915                 4920             


Arg Lys  Ile Val Ser Ile Leu  Asn Pro Ile Tyr Trp  Thr Thr Ala 
    4925                 4930                 4935             


Lys Glu  Ile Gly Glu Ala Val  Asn Gly Phe Thr Leu  Thr Asn Ala 
    4940                 4945                 4950             


Val Phe  Lys Arg Glu Thr Gln  Val Glu Phe Ala Thr  Gly Glu Ile 
    4955                 4960                 4965             


Leu Gln  Met Ser His Ile Ala  Arg Gly Leu Asp Ser  Asp Gly Ser 
    4970                 4975                 4980             


Leu Leu  Leu Asp Ile Val Val  Ser Gly Tyr Val Leu  Gln Leu Gln 
    4985                 4990                 4995             


Ser Pro  Ala Glu Val Thr Val  Lys Asp Tyr Thr Glu  Asp Tyr Ile 
    5000                 5005                 5010             


Gln Thr  Gly Pro Gly Gln Leu  Tyr Ala Tyr Ser Thr  Arg Leu Phe 
    5015                 5020                 5025             


Thr Ile  Asp Gly Ile Ser Ile  Pro Tyr Thr Trp Asn  His Thr Val 
    5030                 5035                 5040             


Phe Tyr  Asp Gln Ala Gln Gly  Arg Met Pro Phe Leu  Val Glu Thr 
    5045                 5050                 5055             


Leu His  Ala Ser Ser Val Glu  Ser Asp Tyr Asn Gln  Ile Glu Glu 
    5060                 5065                 5070             


Thr Leu  Gly Phe Lys Ile His  Ala Ser Ile Ser Lys  Gly Asp Arg 
    5075                 5080                 5085             


Ser Asn  Gln Cys Pro Ser Gly  Phe Thr Leu Asp Ser  Val Gly Pro 
    5090                 5095                 5100             


Phe Cys  Ala Asp Glu Asp Glu  Cys Ala Ala Gly Asn  Pro Cys Ser 
    5105                 5110                 5115             


His Ser  Cys His Asn Ala Met  Gly Thr Tyr Tyr Cys  Ser Cys Pro 
    5120                 5125                 5130             


Lys Gly  Leu Thr Ile Ala Ala  Asp Gly Arg Thr Cys  Gln Asp Ile 
    5135                 5140                 5145             


Asp Glu  Cys Ala Leu Gly Arg  His Thr Cys His Ala  Gly Gln Asp 
    5150                 5155                 5160             


Cys Asp  Asn Thr Ile Gly Ser  Tyr Arg Cys Val Val  Arg Cys Gly 
    5165                 5170                 5175             


Ser Gly  Phe Arg Arg Thr Ser  Asp Gly Leu Ser Cys  Gln Asp Ile 
    5180                 5185                 5190             


Asn Glu  Cys Gln Glu Ser Ser  Pro Cys His Gln Arg  Cys Phe Asn 
    5195                 5200                 5205             


Ala Ile  Gly Ser Phe His Cys  Gly Cys Glu Pro Gly  Tyr Gln Leu 
    5210                 5215                 5220             


Lys Gly  Arg Lys Cys Met Asp  Val Asn Glu Cys Arg  Gln Asn Val 
    5225                 5230                 5235             


Cys Arg  Pro Asp Gln His Cys  Lys Asn Thr Arg Gly  Gly Tyr Lys 
    5240                 5245                 5250             


Cys Ile  Asp Leu Cys Pro Asn  Gly Met Thr Lys Ala  Glu Asn Gly 
    5255                 5260                 5265             


Thr Cys  Ile Asp Ile Asp Glu  Cys Lys Asp Gly Thr  His Gln Cys 
    5270                 5275                 5280             


Arg Tyr  Asn Gln Ile Cys Glu  Asn Thr Arg Gly Ser  Tyr Arg Cys 
    5285                 5290                 5295             


Val Cys  Pro Arg Gly Tyr Arg  Ser Gln Gly Val Gly  Arg Pro Cys 
    5300                 5305                 5310             


Met Asp  Ile Asn Glu Cys Glu  Gln Val Pro Lys Pro  Cys Ala His 
    5315                 5320                 5325             


Gln Cys  Ser Asn Thr Pro Gly  Ser Phe Lys Cys Ile  Cys Pro Pro 
    5330                 5335                 5340             


Gly Gln  His Leu Leu Gly Asp  Gly Lys Ser Cys Ala  Gly Leu Glu 
    5345                 5350                 5355             


Arg Leu  Pro Asn Tyr Gly Thr  Gln Tyr Ser Ser Tyr  Asn Leu Ala 
    5360                 5365                 5370             


Arg Phe  Ser Pro Val Arg Asn  Asn Tyr Gln Pro Gln  Gln His Tyr 
    5375                 5380                 5385             


Arg Gln  Tyr Ser His Leu Tyr  Ser Ser Tyr Ser Glu  Tyr Arg Asn 
    5390                 5395                 5400             


Ser Arg  Thr Ser Leu Ser Arg  Thr Arg Arg Thr Ile  Arg Lys Thr 
    5405                 5410                 5415             


Cys Pro  Glu Gly Ser Glu Ala  Ser His Asp Thr Cys  Val Asp Ile 
    5420                 5425                 5430             


Asp Glu  Cys Glu Asn Thr Asp  Ala Cys Gln His Glu  Cys Lys Asn 
    5435                 5440                 5445             


Thr Phe  Gly Ser Tyr Gln Cys  Ile Cys Pro Pro Gly  Tyr Gln Leu 
    5450                 5455                 5460             


Thr His  Asn Gly Lys Thr Cys  Gln Asp Ile Asp Glu  Cys Leu Glu 
    5465                 5470                 5475             


Gln Asn  Val His Cys Gly Pro  Asn Arg Met Cys Phe  Asn Met Arg 
    5480                 5485                 5490             


Gly Ser  Tyr Gln Cys Ile Asp  Thr Pro Cys Pro Pro  Asn Tyr Gln 
    5495                 5500                 5505             


Arg Asp  Pro Val Ser Gly Phe  Cys Leu Lys Asn Cys  Pro Pro Asn 
    5510                 5515                 5520             


Asp Leu  Glu Cys Ala Leu Ser  Pro Tyr Ala Leu Glu  Tyr Lys Leu 
    5525                 5530                 5535             


Val Ser  Leu Pro Phe Gly Ile  Ala Thr Asn Gln Asp  Leu Ile Arg 
    5540                 5545                 5550             


Leu Val  Ala Tyr Thr Gln Asp  Gly Val Met His Pro  Arg Thr Thr 
    5555                 5560                 5565             


Phe Leu  Met Val Asp Glu Glu  Gln Thr Val Pro Phe  Ala Leu Arg 
    5570                 5575                 5580             


Asp Glu  Asn Leu Lys Gly Val  Val Tyr Thr Thr Arg  Pro Leu Arg 
    5585                 5590                 5595             


Glu Ala  Glu Thr Tyr Arg Met  Arg Val Arg Ala Ser  Ser Tyr Ser 
    5600                 5605                 5610             


Ala Asn  Gly Thr Ile Glu Tyr  Gln Thr Thr Phe Ile  Val Tyr Ile 
    5615                 5620                 5625             


Ala Val  Ser Ala Tyr Pro Tyr  
    5630                 5635 


<210>  5045
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMG20A__Homo_sapiens__NP_001291433

<400>  5045

Met Glu Asn Leu Met Thr Ser Ser Thr Leu Pro Pro Leu Phe Ala Asp 
1               5                   10                  15      


Glu Asp Gly Ser Lys Glu Ser Asn Asp Leu Ala Thr Thr Gly Leu Asn 
            20                  25                  30          


His Pro Glu Val Pro Tyr Ser Ser Gly Ala Thr Ser Ser Thr Asn Asn 
        35                  40                  45              


Pro Glu Phe Val Glu Asp Leu Ser Gln Gly Gln Leu Leu Gln Ser Glu 
    50                  55                  60                  


Ser Ser Asn Ala Ala Glu Gly Asn Glu Gln Arg His Glu Asp Glu Gln 
65                  70                  75                  80  


Arg Ser Lys Arg Gly Gly Trp Ser Lys Gly Arg Lys Arg Lys Lys Pro 
                85                  90                  95      


Leu Arg Asp Ser Asn Ala Pro Lys Ser Pro Leu Thr Gly Tyr Val Arg 
            100                 105                 110         


Phe Met Asn Glu Arg Arg Glu Gln Leu Arg Ala Lys Arg Pro Glu Val 
        115                 120                 125             


Pro Phe Pro Glu Ile Thr Arg Met Leu Gly Asn Glu Trp Ser Lys Leu 
    130                 135                 140                 


Pro Pro Glu Glu Lys Gln Arg Tyr Leu Asp Glu Ala Asp Arg Asp Lys 
145                 150                 155                 160 


Glu Arg Tyr Met Lys Glu Leu Glu Gln Tyr Gln Lys Thr Glu Ala Tyr 
                165                 170                 175     


Lys Val Phe Ser Arg Lys Thr Gln Asp Arg Gln Lys Gly Lys Ser His 
            180                 185                 190         


Arg Gln Asp Ala Ala Arg Gln Ala Thr His Asp His Glu Lys Glu Thr 
        195                 200                 205             


Glu Val Lys Glu Arg Ser Val Phe Asp Ile Pro Ile Phe Thr Glu Glu 
    210                 215                 220                 


Phe Leu Asn His Ser Lys Ala Arg Glu Ala Glu Leu Arg Gln Leu Arg 
225                 230                 235                 240 


Lys Ser Asn Met Glu Phe Glu Glu Arg Asn Ala Ala Leu Gln Lys His 
                245                 250                 255     


Val Glu Ser Met Arg Thr Ala Val Glu Lys Leu Glu Val Asp Val Ile 
            260                 265                 270         


Gln Glu Arg Ser Arg Asn Thr Val Leu Gln Gln His Leu Glu Thr Leu 
        275                 280                 285             


Arg Gln Val Leu Thr Ser Ser Phe Ala Ser Met Pro Leu Pro Gly Ser 
    290                 295                 300                 


Gly Glu Thr Pro Thr Val Asp Thr Ile Asp Ser Tyr Met Asn Arg Leu 
305                 310                 315                 320 


His Ser Ile Ile Leu Ala Asn Pro Gln Asp Asn Glu Asn Phe Ile Ala 
                325                 330                 335     


Thr Val Arg Glu Val Val Asn Arg Leu Asp Arg 
            340                 345         


<210>  5046
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMG20B__Homo_sapiens__NP_006330

<400>  5046

Met Ser His Gly Pro Lys Gln Pro Gly Ala Ala Ala Ala Pro Ala Gly 
1               5                   10                  15      


Gly Lys Ala Pro Gly Gln His Gly Gly Phe Val Val Thr Val Lys Gln 
            20                  25                  30          


Glu Arg Gly Glu Gly Pro Arg Ala Gly Glu Lys Gly Ser His Glu Glu 
        35                  40                  45              


Glu Pro Val Lys Lys Arg Gly Trp Pro Lys Gly Lys Lys Arg Lys Lys 
    50                  55                  60                  


Ile Leu Pro Asn Gly Pro Lys Ala Pro Val Thr Gly Tyr Val Arg Phe 
65                  70                  75                  80  


Leu Asn Glu Arg Arg Glu Gln Ile Arg Thr Arg His Pro Asp Leu Pro 
                85                  90                  95      


Phe Pro Glu Ile Thr Lys Met Leu Gly Ala Glu Trp Ser Lys Leu Gln 
            100                 105                 110         


Pro Thr Glu Lys Gln Arg Tyr Leu Asp Glu Ala Glu Arg Glu Lys Gln 
        115                 120                 125             


Gln Tyr Met Lys Glu Leu Arg Ala Tyr Gln Gln Ser Glu Ala Tyr Lys 
    130                 135                 140                 


Met Cys Thr Glu Lys Ile Gln Glu Lys Lys Ile Lys Lys Glu Asp Ser 
145                 150                 155                 160 


Ser Ser Gly Leu Met Asn Thr Leu Leu Asn Gly His Lys Gly Gly Asp 
                165                 170                 175     


Cys Asp Gly Phe Ser Thr Phe Asp Val Pro Ile Phe Thr Glu Glu Phe 
            180                 185                 190         


Leu Asp Gln Asn Lys Ala Arg Glu Ala Glu Leu Arg Arg Leu Arg Lys 
        195                 200                 205             


Met Asn Val Ala Phe Glu Glu Gln Asn Ala Val Leu Gln Arg His Thr 
    210                 215                 220                 


Gln Ser Met Ser Ser Ala Arg Glu Arg Leu Glu Gln Glu Leu Ala Leu 
225                 230                 235                 240 


Glu Glu Arg Arg Thr Leu Ala Leu Gln Gln Gln Leu Gln Ala Val Arg 
                245                 250                 255     


Gln Ala Leu Thr Ala Ser Phe Ala Ser Leu Pro Val Pro Gly Thr Gly 
            260                 265                 270         


Glu Thr Pro Thr Leu Gly Thr Leu Asp Phe Tyr Met Ala Arg Leu His 
        275                 280                 285             


Gly Ala Ile Glu Arg Asp Pro Ala Gln His Glu Lys Leu Ile Val Arg 
    290                 295                 300                 


Ile Lys Glu Ile Leu Ala Gln Val Ala Ser Glu His Leu 
305                 310                 315         


<210>  5047
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGA1__Homo_sapiens__NP_665912

<400>  5047

Met Ser Glu Ser Ser Ser Lys Ser Ser Gln Pro Leu Ala Ser Lys Gln 
1               5                   10                  15      


Glu Lys Asp Gly Thr Glu Lys Arg Gly Arg Gly Arg Pro Arg Lys Gln 
            20                  25                  30          


Pro Pro Lys Glu Pro Ser Glu Val Pro Thr Pro Lys Arg Pro Arg Gly 
        35                  40                  45              


Arg Pro Lys Gly Ser Lys Asn Lys Gly Ala Ala Lys Thr Arg Lys Thr 
    50                  55                  60                  


Thr Thr Thr Pro Gly Arg Lys Pro Arg Gly Arg Pro Lys Lys Leu Glu 
65                  70                  75                  80  


Lys Glu Glu Glu Glu Gly Ile Ser Gln Glu Ser Ser Glu Glu Glu Gln 
                85                  90                  95      


<210>  5048
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGA2__Homo_sapiens__NP_001287847

<400>  5048

Met Ser Ala Arg Gly Glu Gly Ala Gly Gln Pro Ser Thr Ser Ala Gln 
1               5                   10                  15      


Gly Gln Pro Ala Ala Pro Ala Pro Gln Lys Arg Gly Arg Gly Arg Pro 
            20                  25                  30          


Arg Lys Gln Gln Gln Glu Pro Thr Gly Glu Pro Ser Pro Lys Arg Pro 
        35                  40                  45              


Arg Gly Arg Pro Lys Gly Ser Lys Asn Lys Ser Pro Ser Lys Ala Ala 
    50                  55                  60                  


Gln Lys Lys Ala Glu Ala Thr Gly Glu Lys Arg Pro Arg Gly Arg Pro 
65                  70                  75                  80  


Arg Lys Trp Pro Gln Gln Val Val Gln Lys Lys Pro Ala Gln Val Asn 
                85                  90                  95      


Val Ala Leu Pro Gly Lys Asp His Pro Gly Asn Leu Ile Tyr Leu Leu 
            100                 105                 110         


Phe Ser Lys Asn Ala Thr 
        115             


<210>  5049
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGB1__Homo_sapiens__XP_005266425

<400>  5049

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Phe 
145                 150                 155             


<210>  5050
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGB2__Homo_sapiens__NP_001124161

<400>  5050

Met Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro 
65                  70                  75                  80  


Pro Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys 
            100                 105                 110         


Ile Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Ser Glu Ala Gly Lys Lys Gly Pro Gly 
                165                 170                 175     


Arg Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu 
    


<210>  5051
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGB3__Homo_sapiens__NP_001288157

<400>  5051

Met Ala Lys Gly Asp Pro Lys Lys Pro Lys Gly Lys Met Ser Ala Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys Asn Pro 
            20                  25                  30          


Glu Val Pro Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Gly Lys Glu Lys Ser Lys Phe Asp Glu Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Val Arg Tyr Asp Arg Glu Met Lys Asp Tyr Gly Pro 
65                  70                  75                  80  


Ala Lys Gly Gly Lys Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg Pro 
                85                  90                  95      


Pro Ser Gly Phe Phe Leu Phe Cys Ser Glu Phe Arg Pro Lys Ile Lys 
            100                 105                 110         


Ser Thr Asn Pro Gly Ile Ser Ile Gly Asp Val Ala Lys Lys Leu Gly 
        115                 120                 125             


Glu Met Trp Asn Asn Leu Asn Asp Ser Glu Lys Gln Pro Tyr Ile Thr 
    130                 135                 140                 


Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Val Ala Asp Tyr 
145                 150                 155                 160 


Lys Ser Lys Gly Lys Phe Asp Gly Ala Lys Gly Pro Ala Lys Val Ala 
                165                 170                 175     


Arg Lys Lys Val Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Asp Glu 
        195                 200 


<210>  5052
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGCR__Homo_sapiens__NP_000850

<400>  5052

Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala Ser His 
1               5                   10                  15      


Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys Met Met 
            20                  25                  30          


Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp Asn Tyr 
        35                  40                  45              


Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile Ile Ile 
    50                  55                  60                  


Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe Gln Phe 
65                  70                  75                  80  


Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile Ala Gly 
                85                  90                  95      


Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val Ile His 
            100                 105                 110         


Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro Phe Phe 
        115                 120                 125             


Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Thr Leu Ala Lys Phe Ala 
    130                 135                 140                 


Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala Arg Gly 
145                 150                 155                 160 


Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val Glu Cys 
                165                 170                 175     


Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu Glu Ile 
            180                 185                 190         


Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe Val Phe 
        195                 200                 205             


Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu Ser Arg 
    210                 215                 220                 


Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe Ala Arg 
225                 230                 235                 240 


Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln Arg Val 
                245                 250                 255     


Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His Ser Arg 
            260                 265                 270         


Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Ala Asp Thr Ser Lys 
        275                 280                 285             


Val Ser Leu Gly Leu Asp Glu Asn Val Ser Lys Arg Ile Glu Pro Ser 
    290                 295                 300                 


Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met Asp Ile 
305                 310                 315                 320 


Glu Gln Val Ile Thr Leu Ser Leu Ala Leu Leu Leu Ala Val Lys Tyr 
                325                 330                 335     


Ile Phe Phe Glu Gln Thr Glu Thr Glu Ser Thr Leu Ser Leu Lys Asn 
            340                 345                 350         


Pro Ile Thr Ser Pro Val Val Thr Gln Lys Lys Val Pro Asp Asn Cys 
        355                 360                 365             


Cys Arg Arg Glu Pro Met Leu Val Arg Asn Asn Gln Lys Cys Asp Ser 
    370                 375                 380                 


Val Glu Glu Glu Thr Gly Ile Asn Arg Glu Arg Lys Val Glu Val Ile 
385                 390                 395                 400 


Lys Pro Leu Val Ala Glu Thr Asp Thr Pro Asn Arg Ala Thr Phe Val 
                405                 410                 415     


Val Gly Asn Ser Ser Leu Leu Asp Thr Ser Ser Val Leu Val Thr Gln 
            420                 425                 430         


Glu Pro Glu Ile Glu Leu Pro Arg Glu Pro Arg Pro Asn Glu Glu Cys 
        435                 440                 445             


Leu Gln Ile Leu Gly Asn Ala Glu Lys Gly Ala Lys Phe Leu Ser Asp 
    450                 455                 460                 


Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr Lys 
465                 470                 475                 480 


Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg Arg 
                485                 490                 495     


Gln Leu Leu Ser Lys Lys Leu Ser Glu Pro Ser Ser Leu Gln Tyr Leu 
            500                 505                 510         


Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys Glu 
        515                 520                 525             


Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro Leu 
    530                 535                 540                 


Cys Leu Asp Glu Lys Glu Phe Gln Val Pro Met Ala Thr Thr Glu Gly 
545                 550                 555                 560 


Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu Gly 
                565                 570                 575     


Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly Pro 
            580                 585                 590         


Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala Trp 
        595                 600                 605             


Leu Glu Thr Ser Glu Gly Phe Ala Val Ile Lys Glu Ala Phe Asp Ser 
    610                 615                 620                 


Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Thr Ser Ile Ala Gly 
625                 630                 635                 640 


Arg Asn Leu Tyr Ile Arg Phe Gln Ser Arg Ser Gly Asp Ala Met Gly 
                645                 650                 655     


Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Ser Lys Leu His 
            660                 665                 670         


Glu Tyr Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr Cys 
        675                 680                 685             


Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys 
    690                 695                 700                 


Ser Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu Val 
705                 710                 715                 720 


Leu Lys Thr Thr Thr Glu Ala Met Ile Glu Val Asn Ile Asn Lys Asn 
                725                 730                 735     


Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala His 
            740                 745                 750         


Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Asp Ala 
        755                 760                 765             


Ala Gln Asn Val Gly Ser Ser Asn Cys Ile Thr Leu Met Glu Ala Ser 
    770                 775                 780                 


Gly Pro Thr Asn Glu Asp Leu Tyr Ile Ser Cys Thr Met Pro Ser Ile 
785                 790                 795                 800 


Glu Ile Gly Thr Val Gly Gly Gly Thr Asn Leu Leu Pro Gln Gln Ala 
                805                 810                 815     


Cys Leu Gln Met Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly 
            820                 825                 830         


Glu Asn Ala Arg Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala 
        835                 840                 845             


Gly Glu Leu Ser Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Lys 
    850                 855                 860                 


Ser His Met Ile His Asn Arg Ser Lys Ile Asn Leu Gln Asp Leu Gln 
865                 870                 875                 880 


Gly Ala Cys Thr Lys Lys Thr Ala 
                885             


<210>  5053
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGCS1__Homo_sapiens__NP_002121

<400>  5053

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
1               5                   10                  15      


Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
            20                  25                  30          


Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
        35                  40                  45              


Ile Gly Leu Gly Gln Ala Lys Met Gly Phe Cys Thr Asp Arg Glu Asp 
    50                  55                  60                  


Ile Asn Ser Leu Cys Met Thr Val Val Gln Asn Leu Met Glu Arg Asn 
65                  70                  75                  80  


Asn Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                85                  90                  95      


Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Asn Leu Met Gln Leu Phe 
            100                 105                 110         


Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
    130                 135                 140                 


Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Val Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                165                 170                 175     


Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Leu Ile Phe Glu Arg Gly 
            180                 185                 190         


Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
        195                 200                 205             


Met Leu Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys 
    210                 215                 220                 


Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Cys Lys Lys Ile 
225                 230                 235                 240 


His Ala Gln Trp Gln Lys Glu Gly Asn Asp Lys Asp Phe Thr Leu Asn 
                245                 250                 255     


Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
            260                 265                 270         


Lys Ser Leu Ala Arg Met Leu Leu Asn Asp Phe Leu Asn Asp Gln Asn 
        275                 280                 285             


Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
    290                 295                 300                 


Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
305                 310                 315                 320 


Lys Ala Ser Ser Glu Leu Phe Ser Gln Lys Thr Lys Ala Ser Leu Leu 
                325                 330                 335     


Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
            340                 345                 350         


Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
        355                 360                 365             


Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
    370                 375                 380                 


Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
385                 390                 395                 400 


Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                405                 410                 415     


Gly Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
            420                 425                 430         


Thr His His Leu Val Asn Tyr Ile Pro Gln Gly Ser Ile Asp Ser Leu 
        435                 440                 445             


Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
    450                 455                 460                 


Thr Tyr Ala Arg Arg Pro Thr Pro Asn Asp Asp Thr Leu Asp Glu Gly 
465                 470                 475                 480 


Val Gly Leu Val His Ser Asn Ile Ala Thr Glu His Ile Pro Ser Pro 
                485                 490                 495     


Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ala Ala Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ile Ser Asn Gly Glu His 
        515                 520 


<210>  5054
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGN1__Homo_sapiens__NP_004956

<400>  5054

Met Pro Lys Arg Lys Val Ser Ser Ala Glu Gly Ala Ala Lys Glu Glu 
1               5                   10                  15      


Pro Lys Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Pro Ala Lys Val 
            20                  25                  30          


Glu Ala Lys Pro Lys Lys Ala Ala Ala Lys Asp Lys Ser Ser Asp Lys 
        35                  40                  45              


Lys Val Gln Thr Lys Gly Lys Arg Gly Ala Lys Gly Lys Gln Ala Glu 
    50                  55                  60                  


Val Ala Asn Gln Glu Thr Lys Glu Asp Leu Pro Ala Glu Asn Gly Glu 
65                  70                  75                  80  


Thr Lys Thr Glu Glu Ser Pro Ala Ser Asp Glu Ala Gly Glu Lys Glu 
                85                  90                  95      


Ala Lys Ser Asp 
            100 


<210>  5055
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGN4__Homo_sapiens__NP_006344

<400>  5055

Met Pro Lys Arg Lys Ala Lys Gly Asp Ala Lys Gly Asp Lys Ala Lys 
1               5                   10                  15      


Val Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro 
            20                  25                  30          


Ala Pro Pro Lys Pro Glu Pro Arg Pro Lys Lys Ala Ser Ala Lys Lys 
        35                  40                  45              


Gly Glu Lys Leu Pro Lys Gly Arg Lys Gly Lys Ala Asp Ala Gly Lys 
    50                  55                  60                  


Asp Gly Asn Asn Pro Ala Lys Asn Arg Asp Ala Ser Thr Leu Gln Ser 
65                  70                  75                  80  


Gln Lys Ala Glu Gly Thr Gly Asp Ala Lys 
                85                  90  


<210>  5056
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGN5__Homo_sapiens__NP_110390

<400>  5056

Met Pro Lys Arg Lys Ala Ala Gly Gln Gly Asp Met Arg Gln Glu Pro 
1               5                   10                  15      


Lys Arg Arg Ser Ala Arg Leu Ser Ala Met Leu Val Pro Val Thr Pro 
            20                  25                  30          


Glu Val Lys Pro Lys Arg Thr Ser Ser Ser Arg Lys Met Lys Thr Lys 
        35                  40                  45              


Ser Asp Met Met Glu Glu Asn Ile Asp Thr Ser Ala Gln Ala Val Ala 
    50                  55                  60                  


Glu Thr Lys Gln Glu Ala Val Val Glu Glu Asp Tyr Asn Glu Asn Ala 
65                  70                  75                  80  


Lys Asn Gly Glu Ala Lys Ile Thr Glu Ala Pro Ala Ser Glu Lys Glu 
                85                  90                  95      


Ile Val Glu Val Lys Glu Glu Asn Ile Glu Asp Ala Thr Glu Lys Gly 
            100                 105                 110         


Gly Glu Lys Lys Glu Ala Val Ala Ala Glu Val Lys Asn Glu Glu Glu 
        115                 120                 125             


Asp Gln Lys Glu Asp Glu Glu Asp Gln Asn Glu Glu Lys Gly Glu Ala 
    130                 135                 140                 


Gly Lys Glu Asp Lys Asp Glu Lys Gly Glu Glu Asp Gly Lys Glu Asp 
145                 150                 155                 160 


Lys Asn Gly Asn Glu Lys Gly Glu Asp Ala Lys Glu Lys Glu Asp Gly 
                165                 170                 175     


Lys Lys Gly Glu Asp Gly Lys Gly Asn Gly Glu Asp Gly Lys Glu Lys 
            180                 185                 190         


Gly Glu Asp Glu Lys Glu Glu Glu Asp Arg Lys Glu Thr Gly Asp Gly 
        195                 200                 205             


Lys Glu Asn Glu Asp Gly Lys Glu Lys Gly Asp Lys Lys Glu Gly Lys 
    210                 215                 220                 


Asp Val Lys Val Lys Glu Asp Glu Lys Glu Arg Glu Asp Gly Lys Glu 
225                 230                 235                 240 


Asp Glu Gly Gly Asn Glu Glu Glu Ala Gly Lys Glu Lys Glu Asp Leu 
                245                 250                 255     


Lys Glu Glu Glu Glu Gly Lys Glu Glu Asp Glu Ile Lys Glu Asp Asp 
            260                 265                 270         


Gly Lys Lys Glu Glu Pro Gln Ser Ile Val 
        275                 280         


<210>  5057
<211>  1292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGXB3__Homo_sapiens__NP_055798

<400>  5057

Met Asp Ala Ser Tyr Asp Gly Thr Glu Val Thr Val Val Met Glu Glu 
1               5                   10                  15      


Ile Glu Glu Ala Tyr Cys Tyr Thr Ser Pro Gly Pro Pro Lys Lys Lys 
            20                  25                  30          


Lys Lys Tyr Lys Ile His Gly Glu Lys Thr Lys Lys Pro Arg Ser Ala 
        35                  40                  45              


Tyr Leu Leu Tyr Tyr Tyr Asp Ile Tyr Leu Lys Val Gln Gln Glu Leu 
    50                  55                  60                  


Pro His Leu Pro Gln Ser Glu Ile Asn Lys Lys Ile Ser Glu Ser Trp 
65                  70                  75                  80  


Arg Leu Leu Ser Val Ala Glu Arg Ser Tyr Tyr Leu Glu Lys Ala Lys 
                85                  90                  95      


Leu Glu Lys Glu Gly Leu Asp Pro Asn Ser Lys Leu Ser Ala Leu Thr 
            100                 105                 110         


Ala Val Val Pro Asp Ile Pro Gly Phe Arg Lys Ile Leu Pro Arg Ser 
        115                 120                 125             


Asp Tyr Ile Ile Ile Pro Lys Ser Ser Leu Gln Glu Asp Arg Ser Cys 
    130                 135                 140                 


Pro Gln Leu Glu Leu Cys Val Ala Gln Asn Gln Met Ser Pro Lys Gly 
145                 150                 155                 160 


Pro Pro Leu Val Ser Asn Thr Ala Pro Glu Thr Val Pro Ser His Ala 
                165                 170                 175     


Gly Met Ala Glu Gln Cys Leu Ala Val Glu Ala Leu Ala Glu Glu Val 
            180                 185                 190         


Gly Ala Leu Thr Gln Ser Gly Ala Val Gln Glu Ile Ala Thr Ser Glu 
        195                 200                 205             


Ile Leu Ser Gln Asp Val Leu Leu Glu Asp Ala Ser Leu Glu Val Gly 
    210                 215                 220                 


Glu Ser His Gln Pro Tyr Gln Thr Ser Leu Val Ile Glu Glu Thr Leu 
225                 230                 235                 240 


Val Asn Gly Ser Pro Asp Leu Pro Thr Gly Ser Leu Ala Val Pro His 
                245                 250                 255     


Pro Gln Val Gly Glu Ser Val Ser Val Val Thr Val Met Arg Asp Ser 
            260                 265                 270         


Ser Glu Ser Ser Ser Ser Ala Pro Ala Thr Gln Phe Ile Met Leu Pro 
        275                 280                 285             


Leu Pro Ala Tyr Ser Val Val Glu Asn Pro Thr Ser Ile Lys Leu Thr 
    290                 295                 300                 


Thr Thr Tyr Thr Arg Arg Gly His Gly Thr Cys Thr Ser Pro Gly Cys 
305                 310                 315                 320 


Ser Phe Thr Tyr Val Thr Arg His Lys Pro Pro Lys Cys Pro Thr Cys 
                325                 330                 335     


Gly Asn Phe Leu Gly Gly Lys Trp Ile Pro Lys Glu Lys Pro Ala Lys 
            340                 345                 350         


Val Lys Val Glu Leu Ala Ser Gly Val Ser Ser Lys Gly Ser Val Val 
        355                 360                 365             


Lys Arg Asn Gln Gln Pro Val Thr Thr Glu Gln Asn Ser Ser Lys Glu 
    370                 375                 380                 


Asn Ala Ser Lys Leu Thr Leu Glu Asn Ser Glu Ala Val Ser Gln Leu 
385                 390                 395                 400 


Leu Asn Val Ala Pro Pro Arg Glu Val Gly Glu Glu Ser Glu Trp Glu 
                405                 410                 415     


Glu Val Ile Ile Ser Asp Ala His Val Leu Val Lys Glu Ala Pro Gly 
            420                 425                 430         


Asn Cys Gly Thr Ala Val Thr Lys Thr Pro Val Val Lys Ser Gly Val 
        435                 440                 445             


Gln Pro Glu Val Thr Leu Gly Thr Thr Asp Asn Asp Ser Pro Gly Ala 
    450                 455                 460                 


Asp Val Pro Thr Pro Ser Glu Gly Thr Ser Thr Ser Ser Pro Leu Pro 
465                 470                 475                 480 


Ala Pro Lys Lys Pro Thr Gly Val Asp Leu Leu Thr Pro Gly Ser Arg 
                485                 490                 495     


Ala Pro Glu Leu Lys Gly Arg Ala Arg Gly Lys Pro Ser Leu Leu Ala 
            500                 505                 510         


Ala Ala Arg Pro Met Arg Ala Ile Leu Pro Ala Pro Val Asn Val Gly 
        515                 520                 525             


Arg Gly Ser Ser Met Gly Leu Pro Arg Ala Arg Gln Ala Phe Ser Leu 
    530                 535                 540                 


Ser Asp Lys Thr Pro Ser Val Arg Thr Cys Gly Leu Lys Pro Ser Thr 
545                 550                 555                 560 


Leu Lys Gln Leu Gly Gln Pro Ile Gln Gln Pro Ser Gly Pro Gly Glu 
                565                 570                 575     


Val Lys Leu Pro Ser Gly Pro Ser Asn Arg Thr Ser Gln Val Lys Val 
            580                 585                 590         


Val Glu Val Lys Pro Asp Met Phe Pro Pro Tyr Lys Tyr Ser Cys Thr 
        595                 600                 605             


Val Thr Leu Asp Leu Gly Leu Ala Thr Ser Arg Gly Arg Gly Lys Cys 
    610                 615                 620                 


Lys Asn Pro Ser Cys Ser Tyr Val Tyr Thr Asn Arg His Lys Pro Arg 
625                 630                 635                 640 


Ile Cys Pro Ser Cys Gly Val Asn Leu Ala Lys Asp Arg Thr Glu Lys 
                645                 650                 655     


Thr Thr Lys Ala Ile Glu Val Ser Ser Pro Leu Pro Asp Val Leu Asn 
            660                 665                 670         


Ala Thr Glu Pro Leu Ser Thr Ala Gln Arg Glu Ile Gln Arg Gln Ser 
        675                 680                 685             


Thr Leu Gln Leu Leu Arg Lys Val Leu Gln Ile Pro Glu Asn Glu Ser 
    690                 695                 700                 


Glu Leu Ala Glu Val Phe Ala Leu Ile His Glu Leu Asn Ser Ser Arg 
705                 710                 715                 720 


Leu Ile Leu Ser Asn Val Ser Glu Glu Thr Val Thr Ile Glu Gln Thr 
                725                 730                 735     


Ser Trp Ser Asn Tyr Tyr Glu Ser Pro Ser Thr Gln Cys Leu Leu Cys 
            740                 745                 750         


Ser Ser Pro Leu Phe Lys Gly Gly Gln Asn Ser Leu Ala Gly Pro Gln 
        755                 760                 765             


Glu Cys Trp Leu Leu Thr Ala Ser Arg Leu Gln Thr Val Thr Ala Gln 
    770                 775                 780                 


Val Lys Met Cys Leu Asn Pro His Cys Leu Ala Leu His Ser Phe Ile 
785                 790                 795                 800 


Asp Ile Tyr Thr Gly Leu Phe Asn Val Gly Asn Lys Leu Leu Val Ser 
                805                 810                 815     


Leu Asp Leu Leu Phe Ala Ile Arg Asn Gln Ile Lys Leu Gly Glu Asp 
            820                 825                 830         


Pro Arg Val Ser Ile Asn Val Val Leu Lys Ser Val Gln Glu Gln Thr 
        835                 840                 845             


Glu Lys Thr Leu Thr Ser Glu Glu Leu Ser Gln Leu Gln Glu Leu Leu 
    850                 855                 860                 


Cys Asn Gly Tyr Trp Ala Phe Glu Cys Leu Thr Val Arg Asp Tyr Asn 
865                 870                 875                 880 


Asp Met Ile Cys Gly Ile Cys Gly Val Ala Pro Lys Val Glu Met Ala 
                885                 890                 895     


Gln Arg Ser Glu Glu Asn Val Leu Ala Leu Lys Ser Val Glu Phe Thr 
            900                 905                 910         


Trp Pro Glu Phe Leu Gly Ser Asn Glu Val Asn Val Glu Asp Phe Trp 
        915                 920                 925             


Ala Thr Met Glu Thr Glu Val Ile Glu Gln Val Ala Phe Pro Ala Ser 
    930                 935                 940                 


Ile Pro Ile Thr Lys Phe Asp Ala Ser Val Ile Ala Pro Phe Phe Pro 
945                 950                 955                 960 


Pro Leu Met Arg Gly Ala Val Val Val Asn Thr Glu Lys Asp Lys Asn 
                965                 970                 975     


Leu Asp Val Gln Pro Val Pro Gly Ser Gly Ser Ala Leu Val Arg Leu 
            980                 985                 990         


Leu Gln Glu Gly Thr Cys Lys Leu  Asp Glu Ile Gly Ser  Tyr Ser Glu 
        995                 1000                 1005             


Glu Lys  Leu Gln His Leu Leu  Arg Gln Cys Gly Ile  Pro Phe Gly 
    1010                 1015                 1020             


Ala Glu  Asp Ser Lys Asp Gln  Leu Cys Phe Ser Leu  Leu Ala Leu 
    1025                 1030                 1035             


Tyr Glu  Ser Val Gln Asn Gly  Ala Arg Ala Ile Arg  Pro Pro Arg 
    1040                 1045                 1050             


His Phe  Thr Gly Gly Lys Ile  Tyr Lys Val Cys Pro  His Gln Val 
    1055                 1060                 1065             


Val Cys  Gly Ser Lys Tyr Leu  Val Arg Gly Glu Ser  Ala Arg Asp 
    1070                 1075                 1080             


His Val  Asp Leu Leu Ala Ser  Ser Arg His Trp Pro  Pro Val Tyr 
    1085                 1090                 1095             


Val Val  Asp Met Ala Thr Ser  Val Ala Leu Cys Ala  Asp Leu Cys 
    1100                 1105                 1110             


Tyr Pro  Glu Leu Thr Asn Gln  Met Trp Gly Arg Asn  Gln Gly Cys 
    1115                 1120                 1125             


Phe Ser  Ser Pro Thr Glu Pro  Pro Val Ser Val Ser  Cys Pro Glu 
    1130                 1135                 1140             


Leu Leu  Asp Gln His Tyr Thr  Val Asp Met Thr Glu  Thr Glu His 
    1145                 1150                 1155             


Ser Ile  Gln His Pro Val Thr  Lys Thr Ala Thr Arg  Arg Ile Val 
    1160                 1165                 1170             


His Ala  Gly Leu Gln Pro Asn  Pro Gly Asp Pro Ser  Ala Gly His 
    1175                 1180                 1185             


His Ser  Leu Ala Leu Cys Pro  Glu Leu Ala Pro Tyr  Ala Thr Ile 
    1190                 1195                 1200             


Leu Ala  Ser Ile Val Asp Ser  Lys Pro Asn Gly Val  Arg Gln Arg 
    1205                 1210                 1215             


Pro Ile  Ala Phe Asp Asn Ala  Thr His Tyr Tyr Leu  Tyr Asn Arg 
    1220                 1225                 1230             


Leu Met  Asp Phe Leu Thr Ser  Arg Glu Ile Val Asn  Arg Gln Ile 
    1235                 1240                 1245             


His Asp  Ile Val Gln Ser Cys  Gln Pro Gly Glu Val  Val Ile Arg 
    1250                 1255                 1260             


Asp Thr  Leu Tyr Arg Leu Gly  Val Ala Gln Ile Lys  Thr Glu Thr 
    1265                 1270                 1275             


Glu Glu  Glu Gly Glu Glu Glu  Glu Val Ala Ala Val  Ala Glu 
    1280                 1285                 1290         


<210>  5058
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMGXB4__Homo_sapiens__NP_001003681

<400>  5058

Met Ala Tyr Asp Asp Ser Val Lys Lys Glu Asp Cys Phe Asp Gly Asp 
1               5                   10                  15      


His Thr Phe Glu Asp Ile Gly Leu Ala Ala Gly Arg Ser Gln Arg Glu 
            20                  25                  30          


Lys Lys Arg Ser Tyr Lys Asp Phe Leu Arg Glu Glu Glu Glu Ile Ala 
        35                  40                  45              


Ala Gln Val Arg Asn Ser Ser Lys Lys Lys Leu Lys Asp Ser Glu Leu 
    50                  55                  60                  


Tyr Phe Leu Gly Thr Asp Thr His Lys Lys Lys Arg Lys His Ser Ser 
65                  70                  75                  80  


Asp Asp Tyr Tyr Tyr Gly Asp Ile Ser Ser Leu Glu Ser Ser Gln Lys 
                85                  90                  95      


Lys Lys Lys Lys Ser Ser Pro Gln Ser Thr Asp Thr Ala Met Asp Leu 
            100                 105                 110         


Leu Lys Ala Ile Thr Ser Pro Leu Ala Ala Gly Ser Lys Pro Ser Lys 
        115                 120                 125             


Lys Thr Gly Glu Lys Ser Ser Gly Ser Ser Ser His Ser Glu Ser Lys 
    130                 135                 140                 


Lys Glu His His Arg Lys Lys Val Ser Gly Ser Ser Gly Glu Leu Pro 
145                 150                 155                 160 


Leu Glu Asp Gly Gly Ser His Lys Ser Lys Lys Met Lys Pro Leu Tyr 
                165                 170                 175     


Val Asn Thr Glu Thr Leu Thr Leu Arg Glu Pro Asp Gly Leu Lys Met 
            180                 185                 190         


Lys Leu Ile Leu Ser Pro Lys Glu Lys Gly Ser Ser Ser Val Asp Glu 
        195                 200                 205             


Glu Ser Phe Gln Tyr Pro Ser Gln Gln Ala Thr Val Lys Lys Ser Ser 
    210                 215                 220                 


Lys Lys Ser Ala Arg Asp Glu Gln Gly Ala Leu Leu Leu Gly His Glu 
225                 230                 235                 240 


Leu Gln Ser Phe Leu Lys Thr Ala Arg Lys Lys His Lys Ser Ser Ser 
                245                 250                 255     


Asp Ala His Ser Ser Pro Gly Pro Glu Gly Cys Gly Ser Asp Ala Ser 
            260                 265                 270         


Gln Phe Ala Glu Ser His Ser Ala Asn Leu Asp Leu Ser Gly Leu Glu 
        275                 280                 285             


Pro Ile Leu Val Glu Ser Asp Ser Ser Ser Gly Gly Glu Leu Glu Ala 
    290                 295                 300                 


Gly Glu Leu Val Ile Asp Asp Ser Tyr Arg Glu Ile Lys Lys Lys Lys 
305                 310                 315                 320 


Lys Ser Lys Lys Ser Lys Lys Lys Lys Asp Lys Glu Lys His Lys Glu 
                325                 330                 335     


Lys Arg His Ser Lys Ser Lys Arg Ser Leu Gly Leu Ser Ala Val Pro 
            340                 345                 350         


Val Gly Glu Val Thr Val Thr Ser Gly Pro Pro Pro Ser Ile Pro Tyr 
        355                 360                 365             


Ala Gly Ala Ala Ala Pro Pro Leu Pro Leu Pro Gly Leu His Thr Asp 
    370                 375                 380                 


Gly His Ser Glu Lys Lys Lys Lys Lys Glu Glu Lys Asp Lys Glu Arg 
385                 390                 395                 400 


Glu Arg Gly Glu Lys Pro Lys Lys Lys Asn Met Ser Ala Tyr Gln Val 
                405                 410                 415     


Phe Cys Lys Glu Tyr Arg Val Thr Ile Val Ala Asp His Pro Gly Ile 
            420                 425                 430         


Asp Phe Gly Glu Leu Ser Lys Lys Leu Ala Glu Val Trp Lys Gln Leu 
        435                 440                 445             


Pro Glu Lys Asp Lys Leu Ile Trp Lys Gln Lys Ala Gln Tyr Leu Gln 
    450                 455                 460                 


His Lys Gln Asn Lys Ala Glu Ala Thr Thr Val Lys Arg Lys Ala Ser 
465                 470                 475                 480 


Ser Ser Glu Gly Ser Met Lys Val Lys Ala Ser Ser Val Gly Val Leu 
                485                 490                 495     


Ser Pro Gln Lys Lys Ser Pro Pro Thr Thr Met Leu Leu Pro Ala Ser 
            500                 505                 510         


Pro Ala Lys Ala Pro Glu Thr Glu Pro Ile Asp Val Ala Ala His Leu 
        515                 520                 525             


Gln Leu Leu Gly Glu Ser Leu Ser Leu Ile Gly His Arg Leu Gln Glu 
    530                 535                 540                 


Thr Glu Gly Met Val Ala Val Ser Gly Ser Leu Ser Val Leu Leu Asp 
545                 550                 555                 560 


Ser Ile Ile Cys Ala Leu Gly Pro Leu Ala Cys Leu Thr Thr Gln Leu 
                565                 570                 575     


Pro Glu Leu Asn Gly Cys Pro Lys Gln Val Leu Ser Asn Thr Leu Asp 
            580                 585                 590         


Asn Ile Ala Tyr Ile Met Pro Gly Leu 
        595                 600     


<210>  5059
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMHA1__Homo_sapiens__NP_001245257

<400>  5059

Met Ser Arg Gly Gln Arg Val Leu Lys Gly Leu Leu Gly Trp Val Cys 
1               5                   10                  15      


Thr Trp Thr Trp Ala Trp Arg Ala Arg Leu Gly Ala Arg Gly Cys Gly 
            20                  25                  30          


Leu His Val Leu Cys Pro Arg Asp Leu Pro Leu Pro Pro Glu Glu Leu 
        35                  40                  45              


Pro Arg Lys Asp Gly Ala Asp Ala Val Phe Pro Gly Pro Ser Leu Glu 
    50                  55                  60                  


Pro Pro Ala Gly Ser Ser Gly Val Lys Ala Thr Gly Thr Leu Lys Arg 
65                  70                  75                  80  


Pro Thr Ser Leu Ser Arg His Ala Ser Ala Ala Gly Phe Pro Leu Ser 
                85                  90                  95      


Gly Ala Ala Ser Trp Thr Leu Gly Arg Ser His Arg Ser Pro Leu Thr 
            100                 105                 110         


Ala Ala Ser Pro Gly Glu Leu Pro Thr Glu Gly Ala Gly Pro Asp Val 
        115                 120                 125             


Val Glu Asp Ile Ser His Leu Leu Ala Asp Val Ala Arg Phe Ala Glu 
    130                 135                 140                 


Gly Leu Glu Lys Leu Lys Glu Cys Val Leu Arg Asp Asp Leu Leu Glu 
145                 150                 155                 160 


Ala Arg Arg Pro Arg Ala His Glu Cys Leu Gly Glu Ala Leu Arg Val 
                165                 170                 175     


Met His Gln Ile Ile Ser Lys Tyr Pro Leu Leu Asn Thr Val Glu Thr 
            180                 185                 190         


Leu Thr Ala Ala Gly Thr Leu Ile Ala Lys Val Lys Ala Phe His Tyr 
        195                 200                 205             


Glu Ser Asn Asn Asp Leu Glu Lys Gln Glu Phe Glu Lys Ala Leu Glu 
    210                 215                 220                 


Thr Ile Ala Val Ala Phe Ser Ser Thr Val Ser Glu Phe Leu Met Gly 
225                 230                 235                 240 


Glu Val Asp Ser Ser Thr Leu Leu Ala Val Pro Pro Gly Asp Ser Ser 
                245                 250                 255     


Gln Ser Met Glu Ser Leu Tyr Gly Pro Gly Ser Glu Gly Thr Pro Pro 
            260                 265                 270         


Ser Leu Glu Asp Cys Asp Ala Gly Cys Leu Pro Ala Glu Glu Val Asp 
        275                 280                 285             


Val Leu Leu Gln Arg Cys Glu Gly Gly Val Asp Ala Ala Leu Leu Tyr 
    290                 295                 300                 


Ala Lys Asn Met Ala Lys Tyr Met Lys Asp Leu Ile Ser Tyr Leu Glu 
305                 310                 315                 320 


Lys Arg Thr Thr Leu Glu Met Glu Phe Ala Lys Gly Leu Gln Lys Ile 
                325                 330                 335     


Ala His Asn Cys Arg Gln Ser Val Met Gln Glu Pro His Met Pro Leu 
            340                 345                 350         


Leu Ser Ile Tyr Ser Leu Ala Leu Glu Gln Asp Leu Glu Phe Gly His 
        355                 360                 365             


Ser Met Val Gln Ala Val Gly Thr Leu Gln Thr Gln Thr Phe Met Gln 
    370                 375                 380                 


Pro Leu Thr Leu Arg Arg Leu Glu His Glu Lys Arg Arg Lys Glu Ile 
385                 390                 395                 400 


Lys Glu Ala Trp His Arg Ala Gln Arg Lys Leu Gln Glu Ala Glu Ser 
                405                 410                 415     


Asn Leu Arg Lys Ala Lys Gln Gly Tyr Val Gln Arg Cys Glu Asp His 
            420                 425                 430         


Asp Lys Ala Arg Phe Leu Val Ala Lys Ala Glu Glu Glu Gln Ala Gly 
        435                 440                 445             


Ser Ala Pro Gly Ala Gly Ser Thr Ala Thr Lys Thr Leu Asp Lys Arg 
    450                 455                 460                 


Arg Arg Leu Glu Glu Glu Ala Lys Asn Lys Ala Glu Glu Ala Met Ala 
465                 470                 475                 480 


Thr Tyr Arg Thr Cys Val Ala Asp Ala Lys Thr Gln Lys Gln Glu Leu 
                485                 490                 495     


Glu Asp Thr Lys Val Thr Ala Leu Arg Gln Ile Gln Glu Val Ile Arg 
            500                 505                 510         


Gln Ser Asp Gln Thr Ile Lys Ser Ala Thr Ile Ser Tyr Tyr Gln Met 
        515                 520                 525             


Met His Met Gln Thr Ala Pro Leu Pro Val His Phe Gln Met Leu Cys 
    530                 535                 540                 


Glu Ser Ser Lys Leu Tyr Asp Pro Gly Gln Gln Tyr Ala Ser His Val 
545                 550                 555                 560 


Arg Gln Leu Gln Arg Asp Gln Glu Pro Asp Val His Tyr Asp Phe Glu 
                565                 570                 575     


Pro His Val Ser Ala Asn Ala Trp Ser Pro Val Met Arg Ala Arg Lys 
            580                 585                 590         


Ser Ser Phe Asn Val Ser Asp Val Ala Arg Pro Glu Ala Ala Gly Ser 
        595                 600                 605             


Pro Pro Glu Glu Gly Gly Cys Thr Glu Gly Thr Pro Ala Lys Asp His 
    610                 615                 620                 


Arg Ala Gly Arg Gly His Gln Val His Lys Ser Trp Pro Leu Ser Ile 
625                 630                 635                 640 


Ser Asp Ser Asp Ser Gly Leu Asp Pro Gly Pro Gly Ala Gly Asp Phe 
                645                 650                 655     


Lys Lys Phe Glu Arg Thr Ser Ser Ser Gly Thr Met Ser Ser Thr Glu 
            660                 665                 670         


Glu Leu Val Asp Pro Asp Gly Gly Ala Gly Ala Ser Ala Phe Glu Gln 
        675                 680                 685             


Ala Asp Leu Asn Gly Met Thr Pro Glu Leu Pro Val Ala Val Pro Ser 
    690                 695                 700                 


Gly Pro Phe Arg His Glu Gly Leu Ser Lys Ala Ala Arg Thr His Arg 
705                 710                 715                 720 


Leu Arg Lys Leu Arg Thr Pro Ala Lys Cys Arg Glu Cys Asn Ser Tyr 
                725                 730                 735     


Val Tyr Phe Gln Gly Ala Glu Cys Glu Glu Cys Cys Leu Ala Cys His 
            740                 745                 750         


Lys Lys Cys Leu Glu Thr Leu Ala Ile Gln Cys Gly His Lys Lys Leu 
        755                 760                 765             


Gln Gly Arg Leu Gln Leu Phe Gly Gln Asp Phe Ser His Ala Ala Arg 
    770                 775                 780                 


Ser Ala Pro Asp Gly Val Pro Phe Ile Val Lys Lys Cys Val Cys Glu 
785                 790                 795                 800 


Ile Glu Arg Arg Ala Leu Arg Thr Lys Gly Ile Tyr Arg Val Asn Gly 
                805                 810                 815     


Val Lys Thr Arg Val Glu Lys Leu Cys Gln Ala Phe Glu Asn Gly Lys 
            820                 825                 830         


Glu Leu Val Glu Leu Ser Gln Ala Ser Pro His Asp Ile Ser Asn Val 
        835                 840                 845             


Leu Lys Leu Tyr Leu Arg Gln Leu Pro Glu Pro Leu Ile Ser Phe Arg 
    850                 855                 860                 


Leu Tyr His Glu Leu Val Gly Leu Ala Lys Asp Ser Leu Lys Ala Glu 
865                 870                 875                 880 


Ala Glu Ala Lys Ala Ala Ser Arg Gly Arg Gln Asp Gly Ser Glu Ser 
                885                 890                 895     


Glu Ala Val Ala Val Ala Leu Ala Gly Arg Leu Arg Glu Leu Leu Arg 
            900                 905                 910         


Asp Leu Pro Pro Glu Asn Arg Ala Ser Leu Gln Tyr Leu Leu Arg His 
        915                 920                 925             


Leu Arg Arg Ile Val Glu Val Glu Gln Asp Asn Lys Met Thr Pro Gly 
    930                 935                 940                 


Asn Leu Gly Ile Val Phe Gly Pro Thr Leu Leu Arg Pro Arg Pro Thr 
945                 950                 955                 960 


Glu Ala Thr Val Ser Leu Ser Ser Leu Val Asp Tyr Pro His Gln Ala 
                965                 970                 975     


Arg Val Ile Glu Thr Leu Ile Val His Tyr Gly Leu Val Phe Glu Glu 
            980                 985                 990         


Glu Pro Glu Glu Thr Pro Gly Gly  Gln Asp Glu Ser Ser  Asn Gln Arg 
        995                 1000                 1005             


Ala Glu  Val Val Val Gln Val  Pro Tyr Leu Glu Ala  Gly Glu Ala 
    1010                 1015                 1020             


Val Val  Tyr Pro Leu Gln Glu  Ala Ala Ala Asp Gly  Cys Arg Glu 
    1025                 1030                 1035             


Ser Arg  Val Val Ser Asn Asp  Ser Asp Ser Asp Leu  Glu Glu Ala 
    1040                 1045                 1050             


Ser Glu  Leu Leu Ser Ser Ser  Glu Ala Ser Ala Leu  Gly His Leu 
    1055                 1060                 1065             


Ser Phe  Leu Glu Gln Gln Gln  Ser Glu Ala Ser Leu  Glu Val Ala 
    1070                 1075                 1080             


Ser Gly  Ser His Ser Gly Ser  Glu Glu Gln Leu Glu  Ala Thr Ala 
    1085                 1090                 1095             


Arg Glu  Asp Gly Asp Gly Asp  Glu Asp Gly Pro Ala  Gln Gln Leu 
    1100                 1105                 1110             


Ser Gly  Phe Asn Thr Asn Gln  Ser Asn Asn Val Leu  Gln Ala Pro 
    1115                 1120                 1125             


Leu Pro  Pro Met Arg Leu Arg  Gly Gly Arg Met Thr  Leu Gly Ser 
    1130                 1135                 1140             


Cys Arg  Glu Arg Gln Pro Glu  Phe Val 
    1145                 1150         


<210>  5060
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMMR__Homo_sapiens__NP_001136028

<400>  5060

Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 
1               5                   10                  15      


Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 
            20                  25                  30          


Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 
        35                  40                  45              


Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 
    50                  55                  60                  


Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Lys Glu Ser Gln Lys 
65                  70                  75                  80  


Asn Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu 
                85                  90                  95      


Gln Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu 
            100                 105                 110         


Leu Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr 
        115                 120                 125             


Ser Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu 
    130                 135                 140                 


Thr Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn 
145                 150                 155                 160 


Gln Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn 
                165                 170                 175     


Lys Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met 
            180                 185                 190         


Glu Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly 
        195                 200                 205             


Lys Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys 
    210                 215                 220                 


Ile Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu 
225                 230                 235                 240 


Ile Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala 
                245                 250                 255     


Gln Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu 
            260                 265                 270         


Lys Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu 
        275                 280                 285             


Asp Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His 
    290                 295                 300                 


Val Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln 
305                 310                 315                 320 


Asn Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu 
                325                 330                 335     


Gln Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu 
            340                 345                 350         


Leu Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met 
        355                 360                 365             


Val Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp 
    370                 375                 380                 


Glu Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val 
385                 390                 395                 400 


Lys Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu 
                405                 410                 415     


Leu Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser 
            420                 425                 430         


Ala Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser 
        435                 440                 445             


Met Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys 
    450                 455                 460                 


Ala Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser 
465                 470                 475                 480 


Leu Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln 
                485                 490                 495     


His Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met 
            500                 505                 510         


Leu Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys 
        515                 520                 525             


Glu Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln 
    530                 535                 540                 


Leu Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu 
545                 550                 555                 560 


Gly Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu 
                565                 570                 575     


Ile Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys 
            580                 585                 590         


Pro Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu 
        595                 600                 605             


Leu Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp 
    610                 615                 620                 


Ser Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys 
625                 630                 635                 640 


His Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val 
                645                 650                 655     


Ser Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys 
            660                 665                 670         


Leu Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro 
        675                 680                 685             


Ser Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr 
    690                 695                 700                 


Pro Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys 
705                 710                 715                 720 


Gln Glu Ser Trp Lys 
                725 


<210>  5061
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMOX1__Homo_sapiens__NP_002124

<400>  5061

Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210>  5062
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMOX2__Homo_sapiens__NP_001120676

<400>  5062

Met Ser Ala Glu Val Glu Thr Ser Glu Gly Val Asp Glu Ser Glu Lys 
1               5                   10                  15      


Lys Asn Ser Gly Ala Leu Glu Lys Glu Asn Gln Met Arg Met Ala Asp 
            20                  25                  30          


Leu Ser Glu Leu Leu Lys Glu Gly Thr Lys Glu Ala His Asp Arg Ala 
        35                  40                  45              


Glu Asn Thr Gln Phe Val Lys Asp Phe Leu Lys Gly Asn Ile Lys Lys 
    50                  55                  60                  


Glu Leu Phe Lys Leu Ala Thr Thr Ala Leu Tyr Phe Thr Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Met Glu Arg Asn Lys Asp His Pro Ala Phe Ala Pro 
                85                  90                  95      


Leu Tyr Phe Pro Met Glu Leu His Arg Lys Glu Ala Leu Thr Lys Asp 
            100                 105                 110         


Met Glu Tyr Phe Phe Gly Glu Asn Trp Glu Glu Gln Val Gln Cys Pro 
        115                 120                 125             


Lys Ala Ala Gln Lys Tyr Val Glu Arg Ile His Tyr Ile Gly Gln Asn 
    130                 135                 140                 


Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Met Gly Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Gln Val Leu Lys Lys Val Ala Gln Arg Ala Leu Lys 
                165                 170                 175     


Leu Pro Ser Thr Gly Glu Gly Thr Gln Phe Tyr Leu Phe Glu Asn Val 
            180                 185                 190         


Asp Asn Ala Gln Gln Phe Lys Gln Leu Tyr Arg Ala Arg Met Asn Ala 
        195                 200                 205             


Leu Asp Leu Asn Met Lys Thr Lys Glu Arg Ile Val Glu Glu Ala Asn 
    210                 215                 220                 


Lys Ala Phe Glu Tyr Asn Met Gln Ile Phe Asn Glu Leu Asp Gln Ala 
225                 230                 235                 240 


Gly Ser Thr Leu Ala Arg Glu Thr Leu Glu Asp Gly Phe Pro Val His 
                245                 250                 255     


Asp Gly Lys Gly Asp Met Arg Lys Cys Pro Phe Tyr Ala Ala Glu Gln 
            260                 265                 270         


Asp Lys Gly Ala Leu Glu Gly Ser Ser Cys Pro Phe Arg Thr Ala Met 
        275                 280                 285             


Ala Val Leu Arg Lys Pro Ser Leu Gln Phe Ile Leu Ala Ala Gly Val 
    290                 295                 300                 


Ala Leu Ala Ala Gly Leu Leu Ala Trp Tyr Tyr Met 
305                 310                 315     


<210>  5063
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMP19__Homo_sapiens__NP_057064

<400>  5063

Met Val Lys Leu Asn Ser Asn Pro Ser Glu Lys Gly Thr Lys Pro Pro 
1               5                   10                  15      


Ser Val Glu Asp Gly Phe Gln Thr Val Pro Leu Ile Thr Pro Leu Glu 
            20                  25                  30          


Val Asn His Leu Gln Leu Pro Ala Pro Glu Lys Val Ile Val Lys Thr 
        35                  40                  45              


Arg Thr Glu Tyr Gln Pro Glu Gln Lys Asn Lys Gly Lys Phe Arg Val 
    50                  55                  60                  


Pro Lys Ile Ala Glu Phe Thr Val Thr Ile Leu Val Ser Leu Ala Leu 
65                  70                  75                  80  


Ala Phe Leu Ala Cys Ile Val Phe Leu Val Val Tyr Lys Ala Phe Thr 
                85                  90                  95      


Tyr Asp His Ser Cys Pro Glu Gly Phe Val Tyr Lys His Lys Arg Cys 
            100                 105                 110         


Ile Pro Ala Ser Leu Asp Ala Tyr Tyr Ser Ser Gln Asp Pro Asn Ser 
        115                 120                 125             


Arg Ser Arg Phe Tyr Thr Val Ile Ser His Tyr Ser Val Ala Lys Gln 
    130                 135                 140                 


Ser Thr Ala Arg Ala Ile Gly Pro Trp Leu Ser Ala Ala Ala Val Ile 
145                 150                 155                 160 


His Glu Pro Lys Pro Pro Lys Thr Gln Gly His 
                165                 170     


<210>  5064
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMSD__Homo_sapiens__NP_001116838

<400>  5064

Met Ser Ile Ser Ser Ala Leu Ala Met Val Phe Met Gly Ala Lys Gly 
1               5                   10                  15      


Asn Thr Ala Ala Gln Met Ser Gln Ala Leu Cys Phe Ser Lys Ile Gly 
            20                  25                  30          


Gly Glu Asp Gly Asp Ile His Arg Gly Phe Gln Ser Leu Leu Val Ala 
        35                  40                  45              


Ile Asn Arg Thr Asp Thr Glu Tyr Val Leu Arg Thr Ala Asn Gly Leu 
    50                  55                  60                  


Phe Gly Glu Lys Ser Tyr Asp Phe Leu Thr Gly Phe Thr Asp Ser Cys 
65                  70                  75                  80  


Gly Lys Phe Tyr Gln Ala Thr Ile Lys Gln Leu Asp Phe Val Asn Asp 
                85                  90                  95      


Thr Glu Lys Ser Thr Thr Arg Val Asn Ser Trp Val Ala Asp Lys Thr 
            100                 105                 110         


Lys Gly Glu Asn Ile Leu Leu Phe Tyr Phe Asp Asn Ile Leu Asn Ser 
        115                 120                 125             


Phe Ile Val Ser Ser Leu Gln Asn Cys Gln Ile 
    130                 135                 


<210>  5065
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMX1__Homo_sapiens__NP_061815

<400>  5065

Met Pro Asp Glu Leu Thr Glu Pro Gly Arg Ala Thr Pro Ala Arg Ala 
1               5                   10                  15      


Ser Ser Phe Leu Ile Glu Asn Leu Leu Ala Ala Glu Ala Lys Gly Ala 
            20                  25                  30          


Gly Arg Ala Thr Gln Gly Asp Gly Ser Arg Glu Asp Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Asp Pro Glu Asp Glu Asp Ala Glu Gln Ala Arg Arg Arg Arg 
    50                  55                  60                  


Leu Gln Arg Arg Arg Gln Leu Leu Ala Gly Thr Gly Pro Gly Gly Glu 
65                  70                  75                  80  


Ala Arg Ala Arg Ala Leu Leu Gly Pro Gly Ala Leu Gly Leu Gly Pro 
                85                  90                  95      


Arg Pro Pro Pro Gly Pro Gly Pro Pro Phe Ala Leu Gly Cys Gly Gly 
            100                 105                 110         


Ala Ala Arg Trp Tyr Pro Arg Ala His Gly Gly Tyr Gly Gly Gly Leu 
        115                 120                 125             


Ser Pro Asp Thr Ser Asp Arg Asp Ser Pro Glu Thr Gly Glu Glu Met 
    130                 135                 140                 


Gly Arg Ala Glu Gly Ala Trp Pro Arg Gly Pro Gly Pro Gly Ala Val 
145                 150                 155                 160 


Gln Arg Glu Ala Ala Glu Leu Ala Ala Arg Gly Pro Ala Ala Gly Thr 
                165                 170                 175     


Glu Glu Ala Ser Glu Leu Ala Glu Val Pro Ala Ala Ala Gly Glu Thr 
            180                 185                 190         


Arg Gly Gly Val Gly Val Gly Gly Gly Arg Lys Lys Lys Thr Arg Thr 
        195                 200                 205             


Val Phe Ser Arg Ser Gln Val Phe Gln Leu Glu Ser Thr Phe Asp Leu 
    210                 215                 220                 


Lys Arg Tyr Leu Ser Ser Ala Glu Arg Ala Gly Leu Ala Ala Ser Leu 
225                 230                 235                 240 


Gln Leu Thr Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Asn 
                245                 250                 255     


Lys Trp Lys Arg Gln Leu Ala Ala Glu Leu Glu Ala Ala Ser Leu Ser 
            260                 265                 270         


Pro Pro Gly Ala Gln Arg Leu Val Arg Val Pro Val Leu Tyr His Glu 
        275                 280                 285             


Ser Pro Pro Ala Ala Ala Ala Ala Gly Pro Pro Ala Thr Leu Pro Phe 
    290                 295                 300                 


Pro Leu Ala Pro Ala Ala Pro Ala Pro Pro Pro Pro Leu Leu Gly Phe 
305                 310                 315                 320 


Ser Gly Ala Leu Ala Tyr Pro Leu Ala Ala Phe Pro Ala Ala Ala Ser 
                325                 330                 335     


Val Pro Phe Leu Arg Ala Gln Met Pro Gly Leu Val 
            340                 345             


<210>  5066
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN1__Homo_sapiens__NP_001002032

<400>  5066

Met Thr Thr Thr Thr Thr Phe Lys Gly Val Asp Pro Asn Ser Arg Asn 
1               5                   10                  15      


Ser Ser Arg Val Leu Arg Pro Pro Gly Gly Gly Ser Asn Phe Ser Leu 
            20                  25                  30          


Gly Phe Asp Glu Pro Thr Glu Gln Pro Val Arg Lys Asn Lys Met Ala 
        35                  40                  45              


Ser Asn Ile Phe Gly Thr Pro Glu Glu Asn Gln Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Ala Gly Ala Lys Ser Ser Gly Gly Arg Glu Asp Leu Glu Ser Ser 
65                  70                  75                  80  


Gly Leu Gln Arg Arg Asn Ser Ser Glu Ala Ser Ser Gly Asp Phe Leu 
                85                  90                  95      


Asp Leu Lys Lys Met Trp Thr Gln Thr Cys Gln Ala Ala Trp Gly Arg 
            100                 105                 110         


Val Lys Arg Ser Pro Cys Leu Leu Arg Leu Cys Pro Ala Arg Trp Pro 
        115                 120                 125             


Arg Pro Gln Cys His Pro Glu Glu Ile Pro Leu Ala Ala Ser Pro Ala 
    130                 135                 140                 


Ser Ser Trp Val Ser Ser Asp Cys Pro Glu Arg Cys Arg Ser Val Cys 
145                 150                 155                 160 


Phe Leu His Ala Cys Glu Leu His Asn Leu Ser Leu Thr Val His Leu 
                165                 170                 175     


Leu Asp Leu Phe His 
            180     


<210>  5067
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN1L__Homo_sapiens__NP_653171

<400>  5067

Met Phe Gln Val Pro Asp Ser Glu Gly Gly Arg Ala Gly Ser Arg Ala 
1               5                   10                  15      


Met Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe Gly Ser Pro Glu 
            20                  25                  30          


Glu Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ala Ser Asn Ile Phe 
        35                  40                  45              


Gly Pro Thr Glu Glu Pro Gln Asn Ile Pro Lys Arg Thr Asn Pro Pro 
    50                  55                  60                  


Gly Gly Lys Gly Ser Gly Ile Phe Asp Glu Ser Thr Pro Val Gln Thr 
65                  70                  75                  80  


Arg Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser Asp Ile Phe Gly 
                85                  90                  95      


Ser Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro Asn Lys Pro Lys 
            100                 105                 110         


Asp His Val Phe Leu Cys Glu Gly Glu Glu Pro Lys Ser Asp Leu Lys 
        115                 120                 125             


Ala Ala Arg Ser Ile Pro Ala Gly Ala Glu Pro Gly Glu Lys Gly Ser 
    130                 135                 140                 


Ala Arg Lys Ala Gly Pro Ala Lys Glu Gln Glu Pro Met Pro Thr Val 
145                 150                 155                 160 


Asp Ser His Glu Pro Arg Leu Gly Pro Arg Pro Arg Ser His Asn Lys 
                165                 170                 175     


Val Leu Asn Pro Pro Gly Gly Lys Ser Ser Ile Ser Phe Tyr 
            180                 185                 190 


<210>  5068
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNF1A__Homo_sapiens__NP_000536

<400>  5068

Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu 
            20                  25                  30          


Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu 
        35                  40                  45              


Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu 
    50                  55                  60                  


Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp 
65                  70                  75                  80  


Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu 
                85                  90                  95      


Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro 
            100                 105                 110         


Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile 
        115                 120                 125             


Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu 
    130                 135                 140                 


Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala 
145                 150                 155                 160 


Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln 
                165                 170                 175     


Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp 
            180                 185                 190         


Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro 
        195                 200                 205             


Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro 
    210                 215                 220                 


Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu 
225                 230                 235                 240 


Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser 
                245                 250                 255     


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
            260                 265                 270         


Lys Glu Glu Ala Phe Arg His Lys Leu Ala Met Asp Thr Tyr Ser Gly 
        275                 280                 285             


Pro Pro Pro Gly Pro Gly Pro Gly Pro Ala Leu Pro Ala His Ser Ser 
    290                 295                 300                 


Pro Gly Leu Pro Pro Pro Ala Leu Ser Pro Ser Lys Val His Gly Val 
305                 310                 315                 320 


Arg Tyr Gly Gln Pro Ala Thr Ser Glu Thr Ala Glu Val Pro Ser Ser 
                325                 330                 335     


Ser Gly Gly Pro Leu Val Thr Val Ser Thr Pro Leu His Gln Val Ser 
            340                 345                 350         


Pro Thr Gly Leu Glu Pro Ser His Ser Leu Leu Ser Thr Glu Ala Lys 
        355                 360                 365             


Leu Val Ser Ala Ala Gly Gly Pro Leu Pro Pro Val Ser Thr Leu Thr 
    370                 375                 380                 


Ala Leu His Ser Leu Glu Gln Thr Ser Pro Gly Leu Asn Gln Gln Pro 
385                 390                 395                 400 


Gln Asn Leu Ile Met Ala Ser Leu Pro Gly Val Met Thr Ile Gly Pro 
                405                 410                 415     


Gly Glu Pro Ala Ser Leu Gly Pro Thr Phe Thr Asn Thr Gly Ala Ser 
            420                 425                 430         


Thr Leu Val Ile Gly Leu Ala Ser Thr Gln Ala Gln Ser Val Pro Val 
        435                 440                 445             


Ile Asn Ser Met Gly Ser Ser Leu Thr Thr Leu Gln Pro Val Gln Phe 
    450                 455                 460                 


Ser Gln Pro Leu His Pro Ser Tyr Gln Gln Pro Leu Met Pro Pro Val 
465                 470                 475                 480 


Gln Ser His Val Thr Gln Ser Pro Phe Met Ala Thr Met Ala Gln Leu 
                485                 490                 495     


Gln Ser Pro His Ala Leu Tyr Ser His Lys Pro Glu Val Ala Gln Tyr 
            500                 505                 510         


Thr His Thr Gly Leu Leu Pro Gln Thr Met Leu Ile Thr Asp Thr Thr 
        515                 520                 525             


Asn Leu Ser Ala Leu Ala Ser Leu Thr Pro Thr Lys Gln Val Phe Thr 
    530                 535                 540                 


Ser Asp Thr Glu Ala Ser Ser Glu Ser Gly Leu His Thr Pro Ala Ser 
545                 550                 555                 560 


Gln Ala Thr Thr Leu His Val Pro Ser Gln Asp Pro Ala Gly Ile Gln 
                565                 570                 575     


His Leu Gln Pro Ala His Arg Leu Ser Ala Ser Pro Thr Val Ser Ser 
            580                 585                 590         


Ser Ser Leu Val Leu Tyr Gln Ser Ser Asp Ser Ser Asn Gly Gln Ser 
        595                 600                 605             


His Leu Leu Pro Ser Asn His Ser Val Ile Glu Thr Phe Ile Ser Thr 
    610                 615                 620                 


Gln Met Ala Ser Ser Ser Gln 
625                 630     


<210>  5069
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNF1B__Homo_sapiens__NP_000449

<400>  5069

Met Val Ser Lys Leu Thr Ser Leu Gln Gln Glu Leu Leu Ser Ala Leu 
1               5                   10                  15      


Leu Ser Ser Gly Val Thr Lys Glu Val Leu Val Gln Ala Leu Glu Glu 
            20                  25                  30          


Leu Leu Pro Ser Pro Asn Phe Gly Val Lys Leu Glu Thr Leu Pro Leu 
        35                  40                  45              


Ser Pro Gly Ser Gly Ala Glu Pro Asp Thr Lys Pro Val Phe His Thr 
    50                  55                  60                  


Leu Thr Asn Gly His Ala Lys Gly Arg Leu Ser Gly Asp Glu Gly Ser 
65                  70                  75                  80  


Glu Asp Gly Asp Asp Tyr Asp Thr Pro Pro Ile Leu Lys Glu Leu Gln 
                85                  90                  95      


Ala Leu Asn Thr Glu Glu Ala Ala Glu Gln Arg Ala Glu Val Asp Arg 
            100                 105                 110         


Met Leu Ser Glu Asp Pro Trp Arg Ala Ala Lys Met Ile Lys Gly Tyr 
        115                 120                 125             


Met Gln Gln His Asn Ile Pro Gln Arg Glu Val Val Asp Val Thr Gly 
    130                 135                 140                 


Leu Asn Gln Ser His Leu Ser Gln His Leu Asn Lys Gly Thr Pro Met 
145                 150                 155                 160 


Lys Thr Gln Lys Arg Ala Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln 
                165                 170                 175     


Arg Glu Ile Leu Arg Gln Phe Asn Gln Thr Val Gln Ser Ser Gly Asn 
            180                 185                 190         


Met Thr Asp Lys Ser Ser Gln Asp Gln Leu Leu Phe Leu Phe Pro Glu 
        195                 200                 205             


Phe Ser Gln Gln Ser His Gly Pro Gly Gln Ser Asp Asp Ala Cys Ser 
    210                 215                 220                 


Glu Pro Thr Asn Lys Lys Met Arg Arg Asn Arg Phe Lys Trp Gly Pro 
225                 230                 235                 240 


Ala Ser Gln Gln Ile Leu Tyr Gln Ala Tyr Asp Arg Gln Lys Asn Pro 
                245                 250                 255     


Ser Lys Glu Glu Arg Glu Ala Leu Val Glu Glu Cys Asn Arg Ala Glu 
            260                 265                 270         


Cys Leu Gln Arg Gly Val Ser Pro Ser Lys Ala His Gly Leu Gly Ser 
        275                 280                 285             


Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg 
    290                 295                 300                 


Lys Glu Glu Ala Phe Arg Gln Lys Leu Ala Met Asp Ala Tyr Ser Ser 
305                 310                 315                 320 


Asn Gln Thr His Ser Leu Asn Pro Leu Leu Ser His Gly Ser Pro His 
                325                 330                 335     


His Gln Pro Ser Ser Ser Pro Pro Asn Lys Leu Ser Gly Val Arg Tyr 
            340                 345                 350         


Ser Gln Gln Gly Asn Asn Glu Ile Thr Ser Ser Ser Thr Ile Ser His 
        355                 360                 365             


His Gly Asn Ser Ala Met Val Thr Ser Gln Ser Val Leu Gln Gln Val 
    370                 375                 380                 


Ser Pro Ala Ser Leu Asp Pro Gly His Asn Leu Leu Ser Pro Asp Gly 
385                 390                 395                 400 


Lys Met Ile Ser Val Ser Gly Gly Gly Leu Pro Pro Val Ser Thr Leu 
                405                 410                 415     


Thr Asn Ile His Ser Leu Ser His His Asn Pro Gln Gln Ser Gln Asn 
            420                 425                 430         


Leu Ile Met Thr Pro Leu Ser Gly Val Met Ala Ile Ala Gln Ser Leu 
        435                 440                 445             


Asn Thr Ser Gln Ala Gln Ser Val Pro Val Ile Asn Ser Val Ala Gly 
    450                 455                 460                 


Ser Leu Ala Ala Leu Gln Pro Val Gln Phe Ser Gln Gln Leu His Ser 
465                 470                 475                 480 


Pro His Gln Gln Pro Leu Met Gln Gln Ser Pro Gly Ser His Met Ala 
                485                 490                 495     


Gln Gln Pro Phe Met Ala Ala Val Thr Gln Leu Gln Asn Ser His Met 
            500                 505                 510         


Tyr Ala His Lys Gln Glu Pro Pro Gln Tyr Ser His Thr Ser Arg Phe 
        515                 520                 525             


Pro Ser Ala Met Val Val Thr Asp Thr Ser Ser Ile Ser Thr Leu Thr 
    530                 535                 540                 


Asn Met Ser Ser Ser Lys Gln Cys Pro Leu Gln Ala Trp 
545                 550                 555         


<210>  5070
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNF4A__Homo_sapiens__NP_000448

<400>  5070

Met Arg Leu Ser Lys Thr Leu Val Asp Met Asp Met Ala Asp Tyr Ser 
1               5                   10                  15      


Ala Ala Leu Asp Pro Ala Tyr Thr Thr Leu Glu Phe Glu Asn Val Gln 
            20                  25                  30          


Val Leu Thr Met Gly Asn Asp Thr Ser Pro Ser Glu Gly Thr Asn Leu 
        35                  40                  45              


Asn Ala Pro Asn Ser Leu Gly Val Ser Ala Leu Cys Ala Ile Cys Gly 
    50                  55                  60                  


Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser Ser Cys Asp Gly Cys 
65                  70                  75                  80  


Lys Gly Phe Phe Arg Arg Ser Val Arg Lys Asn His Met Tyr Ser Cys 
                85                  90                  95      


Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp Lys Arg Asn Gln Cys 
            100                 105                 110         


Arg Tyr Cys Arg Leu Lys Lys Cys Phe Arg Ala Gly Met Lys Lys Glu 
        115                 120                 125             


Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr Arg Arg Ser Ser Tyr 
    130                 135                 140                 


Glu Asp Ser Ser Leu Pro Ser Ile Asn Ala Leu Leu Gln Ala Glu Val 
145                 150                 155                 160 


Leu Ser Arg Gln Ile Thr Ser Pro Val Ser Gly Ile Asn Gly Asp Ile 
                165                 170                 175     


Arg Ala Lys Lys Ile Ala Ser Ile Ala Asp Val Cys Glu Ser Met Lys 
            180                 185                 190         


Glu Gln Leu Leu Val Leu Val Glu Trp Ala Lys Tyr Ile Pro Ala Phe 
        195                 200                 205             


Cys Glu Leu Pro Leu Asp Asp Gln Val Ala Leu Leu Arg Ala His Ala 
    210                 215                 220                 


Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg Ser Met Val Phe Lys 
225                 230                 235                 240 


Asp Val Leu Leu Leu Gly Asn Asp Tyr Ile Val Pro Arg His Cys Pro 
                245                 250                 255     


Glu Leu Ala Glu Met Ser Arg Val Ser Ile Arg Ile Leu Asp Glu Leu 
            260                 265                 270         


Val Leu Pro Phe Gln Glu Leu Gln Ile Asp Asp Asn Glu Tyr Ala Tyr 
        275                 280                 285             


Leu Lys Ala Ile Ile Phe Phe Asp Pro Asp Ala Lys Gly Leu Ser Asp 
    290                 295                 300                 


Pro Gly Lys Ile Lys Arg Leu Arg Ser Gln Val Gln Val Ser Leu Glu 
305                 310                 315                 320 


Asp Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly Arg Phe Gly Glu 
                325                 330                 335     


Leu Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr Trp Gln Met Ile 
            340                 345                 350         


Glu Gln Ile Gln Phe Ile Lys Leu Phe Gly Met Ala Lys Ile Asp Asn 
        355                 360                 365             


Leu Leu Gln Glu Met Leu Leu Gly Gly Ser Pro Ser Asp Ala Pro His 
    370                 375                 380                 


Ala His His Pro Leu His Pro His Leu Met Gln Glu His Met Gly Thr 
385                 390                 395                 400 


Asn Val Ile Val Ala Asn Thr Met Pro Thr His Leu Ser Asn Gly Gln 
                405                 410                 415     


Met Cys Glu Trp Pro Arg Pro Arg Gly Gln Ala Ala Thr Pro Glu Thr 
            420                 425                 430         


Pro Gln Pro Ser Pro Pro Gly Gly Ser Gly Ser Glu Pro Tyr Lys Leu 
        435                 440                 445             


Leu Pro Gly Ala Val Ala Thr Ile Val Lys Pro Leu Ser Ala Ile Pro 
    450                 455                 460                 


Gln Pro Thr Ile Thr Lys Gln Glu Val Ile 
465                 470                 


<210>  5071
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNF4G__Homo_sapiens__NP_004124

<400>  5071

Met Asp Met Ala Asn Tyr Ser Glu Val Leu Asp Pro Thr Tyr Thr Thr 
1               5                   10                  15      


Leu Glu Phe Glu Thr Met Gln Ile Leu Tyr Asn Ser Ser Asp Ser Ser 
            20                  25                  30          


Ala Pro Glu Thr Ser Met Asn Thr Thr Asp Asn Gly Val Asn Cys Leu 
        35                  40                  45              


Cys Ala Ile Cys Gly Asp Arg Ala Thr Gly Lys His Tyr Gly Ala Ser 
    50                  55                  60                  


Ser Cys Asp Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Arg Lys Ser 
65                  70                  75                  80  


His Val Tyr Ser Cys Arg Phe Ser Arg Gln Cys Val Val Asp Lys Asp 
                85                  90                  95      


Lys Arg Asn Gln Cys Arg Tyr Cys Arg Leu Arg Lys Cys Phe Arg Ala 
            100                 105                 110         


Gly Met Lys Lys Glu Ala Val Gln Asn Glu Arg Asp Arg Ile Ser Thr 
        115                 120                 125             


Arg Arg Ser Thr Phe Asp Gly Ser Asn Ile Pro Ser Ile Asn Thr Leu 
    130                 135                 140                 


Ala Gln Ala Glu Val Arg Ser Arg Gln Ile Ser Val Ser Ser Pro Gly 
145                 150                 155                 160 


Ser Ser Thr Asp Ile Asn Val Lys Lys Ile Ala Ser Ile Gly Asp Val 
                165                 170                 175     


Cys Glu Ser Met Lys Gln Gln Leu Leu Val Leu Val Glu Trp Ala Lys 
            180                 185                 190         


Tyr Ile Pro Ala Phe Cys Glu Leu Pro Leu Asp Asp Gln Val Ala Leu 
        195                 200                 205             


Leu Arg Ala His Ala Gly Glu His Leu Leu Leu Gly Ala Thr Lys Arg 
    210                 215                 220                 


Ser Met Met Tyr Lys Asp Ile Leu Leu Leu Gly Asn Asn Tyr Val Ile 
225                 230                 235                 240 


His Arg Asn Ser Cys Glu Val Glu Ile Ser Arg Val Ala Asn Arg Val 
                245                 250                 255     


Leu Asp Glu Leu Val Arg Pro Phe Gln Glu Ile Gln Ile Asp Asp Asn 
            260                 265                 270         


Glu Tyr Ala Cys Leu Lys Ala Ile Val Phe Phe Asp Pro Asp Ala Lys 
        275                 280                 285             


Gly Leu Ser Asp Pro Val Lys Ile Lys Asn Met Arg Phe Gln Val Gln 
    290                 295                 300                 


Ile Gly Leu Glu Asp Tyr Ile Asn Asp Arg Gln Tyr Asp Ser Arg Gly 
305                 310                 315                 320 


Arg Phe Gly Glu Leu Leu Leu Leu Leu Pro Thr Leu Gln Ser Ile Thr 
                325                 330                 335     


Trp Gln Met Ile Glu Gln Ile Gln Phe Val Lys Leu Phe Gly Met Val 
            340                 345                 350         


Lys Ile Asp Asn Leu Leu Gln Glu Met Leu Leu Gly Gly Ala Ser Asn 
        355                 360                 365             


Asp Gly Ser His Leu His His Pro Met His Pro His Leu Ser Gln Asp 
    370                 375                 380                 


Pro Leu Thr Gly Gln Thr Ile Leu Leu Gly Pro Met Ser Thr Leu Val 
385                 390                 395                 400 


His Ala Asp Gln Ile Ser Thr Pro Glu Thr Pro Leu Pro Ser Pro Pro 
                405                 410                 415     


Gln Gly Ser Gly Gln Glu Gln Tyr Lys Ile Ala Ala Asn Gln Ala Ser 
            420                 425                 430         


Val Ile Ser His Gln His Leu Ser Lys Gln Lys Gln Leu 
        435                 440                 445 


<210>  5072
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNMT__Homo_sapiens__NP_001019245

<400>  5072

Met Ala Ser Ser Met Arg Ser Leu Phe Ser Asp His Gly Lys Tyr Val 
1               5                   10                  15      


Glu Ser Phe Arg Arg Phe Leu Asn His Ser Thr Glu His Gln Cys Met 
            20                  25                  30          


Gln Glu Phe Met Asp Lys Lys Leu Pro Gly Ile Ile Gly Arg Tyr Gln 
        35                  40                  45              


Asn Cys Cys 
    50      


<210>  5073
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPA0__Homo_sapiens__NP_006796

<400>  5073

Met Glu Asn Ser Gln Leu Cys Lys Leu Phe Ile Gly Gly Leu Asn Val 
1               5                   10                  15      


Gln Thr Ser Glu Ser Gly Leu Arg Gly His Phe Glu Ala Phe Gly Thr 
            20                  25                  30          


Leu Thr Asp Cys Val Val Val Val Asn Pro Gln Thr Lys Arg Ser Arg 
        35                  40                  45              


Cys Phe Gly Phe Val Thr Tyr Ser Asn Val Glu Glu Ala Asp Ala Ala 
    50                  55                  60                  


Met Ala Ala Ser Pro His Ala Val Asp Gly Asn Thr Val Glu Leu Lys 
65                  70                  75                  80  


Arg Ala Val Ser Arg Glu Asp Ser Ala Arg Pro Gly Ala His Ala Lys 
                85                  90                  95      


Val Lys Lys Leu Phe Val Gly Gly Leu Lys Gly Asp Val Ala Glu Gly 
            100                 105                 110         


Asp Leu Ile Glu His Phe Ser Gln Phe Gly Thr Val Glu Lys Ala Glu 
        115                 120                 125             


Ile Ile Ala Asp Lys Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val 
    130                 135                 140                 


Tyr Phe Gln Asn His Asp Ala Ala Asp Lys Ala Ala Val Val Lys Phe 
145                 150                 155                 160 


His Pro Ile Gln Gly His Arg Val Glu Val Lys Lys Ala Val Pro Lys 
                165                 170                 175     


Glu Asp Ile Tyr Ser Gly Gly Gly Gly Gly Gly Ser Arg Ser Ser Arg 
            180                 185                 190         


Gly Gly Arg Gly Gly Arg Gly Arg Gly Gly Gly Arg Asp Gln Asn Gly 
        195                 200                 205             


Leu Ser Lys Gly Gly Gly Gly Gly Tyr Asn Ser Tyr Gly Gly Tyr Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Tyr Asn Ala Tyr Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Tyr Gly Gly Ser Asp Tyr Gly Asn Gly Phe Gly Gly Phe Gly 
                245                 250                 255     


Ser Tyr Ser Gln His Gln Ser Ser Tyr Gly Pro Met Lys Ser Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Ser Trp Gly Gly Arg Ser Asn Ser Gly 
        275                 280                 285             


Pro Tyr Arg Gly Gly Tyr Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser 
    290                 295                 300                 


Phe 
305 


<210>  5074
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPA1__Homo_sapiens__NP_002127

<400>  5074

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210>  5075
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPA2B1__Homo_sapiens__NP_002128

<400>  5075

Met Glu Arg Glu Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu 
1               5                   10                  15      


Ser Phe Glu Thr Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp 
            20                  25                  30          


Gly Lys Leu Thr Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg 
        35                  40                  45              


Ser Arg Gly Phe Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp 
    50                  55                  60                  


Ala Ala Met Ala Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu 
65                  70                  75                  80  


Pro Lys Arg Ala Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His 
                85                  90                  95      


Val Thr Val Lys Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu 
            100                 105                 110         


Glu His His Leu Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr 
        115                 120                 125             


Ile Glu Ile Ile Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly 
    130                 135                 140                 


Phe Val Thr Phe Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln 
145                 150                 155                 160 


Lys Tyr His Thr Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu 
                165                 170                 175     


Ser Arg Gln Glu Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly 
            180                 185                 190         


Gly Asn Phe Gly Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly 
        195                 200                 205             


Pro Gly Pro Gly Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser 
    210                 215                 220                 


Gly Arg Gly Phe Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly 
225                 230                 235                 240 


Gly Gly Asn Phe Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly 
                245                 250                 255     


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
            260                 265                 270         


Gly Gly Tyr Asp Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr 
        275                 280                 285             


Asn Asp Phe Gly Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met 
    290                 295                 300                 


Lys Ser Gly Asn Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly 
305                 310                 315                 320 


Gly Gly Asn Tyr Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly 
                325                 330                 335     


Gly Arg Ser Arg Tyr 
            340     


<210>  5076
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPA3__Homo_sapiens__XP_005246437

<400>  5076

Met Glu Val Lys Pro Pro Pro Gly Arg Pro Gln Pro Asp Ser Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Gly Glu Glu Gly His Asp Pro Lys Glu Pro Glu 
            20                  25                  30          


Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp 
        35                  40                  45              


Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys 
    50                  55                  60                  


Val Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe 
65                  70                  75                  80  


Val Thr Tyr Ser Cys Val Glu Glu Val Asp Ala Ala Met Cys Ala Arg 
                85                  90                  95      


Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser 
            100                 105                 110         


Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr Val Lys Lys Ile 
        115                 120                 125             


Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp 
    130                 135                 140                 


Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu Val Met Glu Asp 
145                 150                 155                 160 


Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp 
                165                 170                 175     


His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr His Thr Ile Asn 
            180                 185                 190         


Gly His Asn Cys Glu Val Lys Lys Ala Leu Ser Lys Gln Glu Met Gln 
        195                 200                 205             


Ser Ala Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Phe Met 
    210                 215                 220                 


Gly Arg Gly Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser 
                245                 250                 255     


Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly 
            260                 265                 270         


Asp Gly Gly Asn Tyr Gly Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly 
        275                 280                 285             


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
    290                 295                 300                 


Gly Gly Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly 
305                 310                 315                 320 


Gly Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser 
                325                 330                 335     


Gly Gln Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly 
            340                 345                 350         


Gly Arg Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Tyr Gly Ser Arg Arg Phe 
    370                 375             


<210>  5077
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPAB__Homo_sapiens__NP_004490

<400>  5077

Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro 
        35                  40                  45              


Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys 
    50                  55                  60                  


Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp 
65                  70                  75                  80  


Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val 
                85                  90                  95      


Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly 
            100                 105                 110         


Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu 
        115                 120                 125             


Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Gly Ser Thr Asn Tyr Gly Lys Ser 
            260                 265                 270         


Gln Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
        275                 280                 285 


<210>  5078
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPC__Homo_sapiens__XP_011535013

<400>  5078

Met Ala Ser Asn Val Thr Asn Lys Thr Asp Pro Arg Ser Met Asn Ser 
1               5                   10                  15      


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30          


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Val Gly Cys Ser Val 
        35                  40                  45              


His Lys Gly Phe Ala Phe Val Gln Tyr Val Asn Glu Arg Asn Ala Arg 
    50                  55                  60                  


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Gly Gln Val Leu 
65                  70                  75                  80  


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Lys Ala Gly 
                85                  90                  95      


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Val Thr Glu His Pro 
            100                 105                 110         


Ser Pro Ser Pro Leu Leu Ser Ser Ser Phe Asp Leu Asp Tyr Asp Phe 
        115                 120                 125             


Gln Arg Asp Tyr Tyr Asp Arg Met Tyr Ser Tyr Pro Ala Arg Val Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ile Ala Arg Ala Val Val Pro Ser Lys Arg Gln Arg 
145                 150                 155                 160 


Val Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe Asn Ser Lys 
                165                 170                 175     


Ser Gly Gln Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys Gly Asp Asp 
            180                 185                 190         


Leu Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp 
        195                 200                 205             


Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln Ser Lys Gln 
    210                 215                 220                 


Ala Val Glu Met Lys Asn Asp Lys Ser Glu Glu Glu Gln Ser Ser Ser 
225                 230                 235                 240 


Ser Val Lys Lys Asp Glu Thr Asn Val Lys Met Glu Ser Glu Gly Gly 
                245                 250                 255     


Ala Asp Asp Ser Ala Glu Glu Gly Asp Leu Leu Asp Asp Asp Asp Asn 
            260                 265                 270         


Glu Asp Arg Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp Asp Glu Lys 
        275                 280                 285             


Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Ala Asn Gly Glu Asp 
    290                 295                 300                 


Asp Ser 
305     


<210>  5079
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPD__Homo_sapiens__NP_001003810

<400>  5079

Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly Lys Met 
65                  70                  75                  80  


Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp Leu Lys Asp 
                85                  90                  95      


Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu Lys Leu Asp 
            100                 105                 110         


Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu Phe Lys Glu 
        115                 120                 125             


Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His Lys Leu Asn 
    130                 135                 140                 


Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys Thr Lys Glu 
145                 150                 155                 160 


Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp Thr Pro Glu 
                165                 170                 175     


Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val Glu Ser Ile 
            180                 185                 190         


Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly Phe Cys Phe 
        195                 200                 205             


Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met Glu Lys Lys 
    210                 215                 220                 


Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val Ala Met Ser 
225                 230                 235                 240 


Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg Gly Gly Phe 
                245                 250                 255     


Ala Gly Arg Ala Arg Gly Arg Gly Gly Asp Gln Gln Ser Gly Tyr Gly 
            260                 265                 270         


Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr Lys Pro Tyr 
        275                 280                 285         


<210>  5080
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPDL__Homo_sapiens__NP_001193929

<400>  5080

Met Glu Val Pro Pro Arg Leu Ser His Val Pro Pro Pro Leu Phe Pro 
1               5                   10                  15      


Ser Ala Pro Ala Thr Leu Ala Ser Arg Ser Leu Ser His Trp Arg Pro 
            20                  25                  30          


Arg Pro Pro Arg Gln Leu Ala Pro Leu Leu Pro Ser Leu Ala Pro Ser 
        35                  40                  45              


Ser Ala Arg Gln Gly Ala Arg Arg Ala Gln Arg His Val Thr Ala Gln 
    50                  55                  60                  


Gln Pro Ser Arg Leu Ala Gly Gly Ala Ala Ile Lys Gly Gly Arg Arg 
65                  70                  75                  80  


Arg Arg Pro Asp Leu Phe Arg Arg His Phe Lys Ser Ser Ser Ile Gln 
                85                  90                  95      


Arg Ser Ala Ala Ala Ala Ala Ala Thr Arg Thr Ala Arg Gln His Pro 
            100                 105                 110         


Pro Ala Asp Ser Ser Val Thr Met Glu Asp Met Asn Glu Tyr Ser Asn 
        115                 120                 125             


Ile Glu Glu Phe Ala Glu Gly Ser Lys Ile Asn Ala Ser Lys Asn Gln 
    130                 135                 140                 


Gln Asp Asp Gly Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Ser 
145                 150                 155                 160 


Lys Lys Asp Leu Thr Glu Tyr Leu Ser Arg Phe Gly Glu Val Val Asp 
                165                 170                 175     


Cys Thr Ile Lys Thr Asp Pro Val Thr Gly Arg Ser Arg Gly Phe Gly 
            180                 185                 190         


Phe Val Leu Phe Lys Asp Ala Ala Ser Val Asp Lys Val Leu Glu Leu 
        195                 200                 205             


Lys Glu His Lys Leu Asp Gly Lys Leu Ile Asp Pro Lys Arg Ala Lys 
    210                 215                 220                 


Ala Leu Lys Gly Lys Glu Pro Pro Lys Lys Val Phe Val Gly Gly Leu 
225                 230                 235                 240 


Ser Pro Asp Thr Ser Glu Glu Gln Ile Lys Glu Tyr Phe Gly Ala Phe 
                245                 250                 255     


Gly Glu Ile Glu Asn Ile Glu Leu Pro Met Asp Thr Lys Thr Asn Glu 
            260                 265                 270         


Arg Arg Gly Phe Cys Phe Ile Thr Tyr Thr Asp Glu Glu Pro Val Lys 
        275                 280                 285             


Lys Leu Leu Glu Ser Arg Tyr His Gln Ile Gly Ser Gly Lys Cys Glu 
    290                 295                 300                 


Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Arg Gln Gln Gln Gln Gln 
305                 310                 315                 320 


Gln Lys Gly Gly Arg Gly Ala Ala Ala Gly Gly Arg Gly Gly Thr Arg 
                325                 330                 335     


Gly Arg Gly Arg Gly Gln Gln Ser Thr Tyr Gly Lys Ala Ser Arg Gly 
            340                 345                 350         


Gly Gly Asn His Gln Asn Asn Tyr Gln Pro Tyr 
        355                 360             


<210>  5081
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPF__Homo_sapiens__NP_001091676

<400>  5081

Met Met Leu Gly Pro Glu Gly Gly Glu Gly Phe Val Val Lys Leu Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Val Glu Asp Val Gln Asn Phe Leu Ser 
            20                  25                  30          


Asp Cys Thr Ile His Asp Gly Ala Ala Gly Val His Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Gln Ser Gly Glu Ala Phe Val Glu Leu Gly Ser Glu 
    50                  55                  60                  


Asp Asp Val Lys Met Ala Leu Lys Lys Asp Arg Glu Ser Met Gly His 
65                  70                  75                  80  


Arg Tyr Ile Glu Val Phe Lys Ser His Arg Thr Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Ser Gly Pro Asn Ser Ala Asp Ser Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Thr Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Pro Glu Gly Lys Ile Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Leu Ala Glu Lys Ala Leu Gly Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Val Phe Lys Ser Ser Gln Glu Glu Val Arg 
            180                 185                 190         


Ser Tyr Ser Asp Pro Pro Leu Lys Phe Met Ser Val Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Thr Ala Arg Arg Tyr Ile Gly Ile Val Lys 
    210                 215                 220                 


Gln Ala Gly Leu Glu Arg Met Arg Pro Gly Ala Tyr Ser Thr Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Glu Glu Tyr Ser Gly Leu Ser Asp Gly Tyr Gly Phe Thr 
                245                 250                 255     


Thr Asp Leu Phe Gly Arg Asp Leu Ser Tyr Cys Leu Ser Gly Met Tyr 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Ser Glu Phe Thr Val Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Lys Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Glu Ala Val Ala Ala Met Ser Lys Asp Arg Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Thr Gly Ala Ser 
        355                 360                 365             


Asn Gly Ala Tyr Ser Ser Gln Val Met Gln Gly Met Gly Val Ser Ala 
    370                 375                 380                 


Ala Gln Ala Thr Tyr Ser Gly Leu Glu Ser Gln Ser Val Ser Gly Cys 
385                 390                 395                 400 


Tyr Gly Ala Gly Tyr Ser Gly Gln Asn Ser Met Gly Gly Tyr Asp 
                405                 410                 415 


<210>  5082
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPH1__Homo_sapiens__NP_005511

<400>  5082

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210>  5083
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPH2__Homo_sapiens__NP_001027565

<400>  5083

Met Met Leu Ser Thr Glu Gly Arg Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Met Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Thr Ser Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Glu Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Ser Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Met Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Gly Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Ser Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Met Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ala Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Thr Ser 
        355                 360                 365             


Gly Gly Ala Tyr Asp His Ser Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Tyr Gln Ser Asn Leu 
        435                 440                 445             


Ala 
    


<210>  5084
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPK__Homo_sapiens__NP_112553

<400>  5084

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ala Asp Val Glu Gly Phe 
    450                 455                 460                 


<210>  5085
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPL__Homo_sapiens__NP_001524

<400>  5085

Met Ser Arg Arg Leu Leu Pro Arg Ala Glu Lys Arg Arg Arg Arg Leu 
1               5                   10                  15      


Glu Gln Arg Gln Gln Pro Asp Glu Gln Arg Arg Arg Ser Gly Ala Met 
            20                  25                  30          


Val Lys Met Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Arg Tyr Tyr 
        35                  40                  45              


Gly Gly Gly Ser Glu Gly Gly Arg Ala Pro Lys Arg Leu Lys Thr Asp 
    50                  55                  60                  


Asn Ala Gly Asp Gln His Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala 
65                  70                  75                  80  


Gly Ala Ala Gly Gly Gly Gly Gly Gly Glu Asn Tyr Asp Asp Pro His 
                85                  90                  95      


Lys Thr Pro Ala Ser Pro Val Val His Ile Arg Gly Leu Ile Asp Gly 
            100                 105                 110         


Val Val Glu Ala Asp Leu Val Glu Ala Leu Gln Glu Phe Gly Pro Ile 
        115                 120                 125             


Ser Tyr Val Val Val Met Pro Lys Lys Arg Gln Ala Leu Val Glu Phe 
    130                 135                 140                 


Glu Asp Val Leu Gly Ala Cys Asn Ala Val Asn Tyr Ala Ala Asp Asn 
145                 150                 155                 160 


Gln Ile Tyr Ile Ala Gly His Pro Ala Phe Val Asn Tyr Ser Thr Ser 
                165                 170                 175     


Gln Lys Ile Ser Arg Pro Gly Asp Ser Asp Asp Ser Arg Ser Val Asn 
            180                 185                 190         


Ser Val Leu Leu Phe Thr Ile Leu Asn Pro Ile Tyr Ser Ile Thr Thr 
        195                 200                 205             


Asp Val Leu Tyr Thr Ile Cys Asn Pro Cys Gly Pro Val Gln Arg Ile 
    210                 215                 220                 


Val Ile Phe Arg Lys Asn Gly Val Gln Ala Met Val Glu Phe Asp Ser 
225                 230                 235                 240 


Val Gln Ser Ala Gln Arg Ala Lys Ala Ser Leu Asn Gly Ala Asp Ile 
                245                 250                 255     


Tyr Ser Gly Cys Cys Thr Leu Lys Ile Glu Tyr Ala Lys Pro Thr Arg 
            260                 265                 270         


Leu Asn Val Phe Lys Asn Asp Gln Asp Thr Trp Asp Tyr Thr Asn Pro 
        275                 280                 285             


Asn Leu Ser Gly Gln Gly Asp Pro Gly Ser Asn Pro Asn Lys Arg Gln 
    290                 295                 300                 


Arg Gln Pro Pro Leu Leu Gly Asp His Pro Ala Glu Tyr Gly Gly Pro 
305                 310                 315                 320 


His Gly Gly Tyr His Ser His Tyr His Asp Glu Gly Tyr Gly Pro Pro 
                325                 330                 335     


Pro Pro His Tyr Glu Gly Arg Arg Met Gly Pro Pro Val Gly Gly His 
            340                 345                 350         


Arg Arg Gly Pro Ser Arg Tyr Gly Pro Gln Tyr Gly His Pro Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Glu Tyr Gly Pro His Ala Asp Ser Pro Val Leu 
    370                 375                 380                 


Met Val Tyr Gly Leu Asp Gln Ser Lys Met Asn Cys Asp Arg Val Phe 
385                 390                 395                 400 


Asn Val Phe Cys Leu Tyr Gly Asn Val Glu Lys Val Lys Phe Met Lys 
                405                 410                 415     


Ser Lys Pro Gly Ala Ala Met Val Glu Met Ala Asp Gly Tyr Ala Val 
            420                 425                 430         


Asp Arg Ala Ile Thr His Leu Asn Asn Asn Phe Met Phe Gly Gln Lys 
        435                 440                 445             


Leu Asn Val Cys Val Ser Lys Gln Pro Ala Ile Met Pro Gly Gln Ser 
    450                 455                 460                 


Tyr Gly Leu Glu Asp Gly Ser Cys Ser Tyr Lys Asp Phe Ser Glu Ser 
465                 470                 475                 480 


Arg Asn Asn Arg Phe Ser Thr Pro Glu Gln Ala Ala Lys Asn Arg Ile 
                485                 490                 495     


Gln His Pro Ser Asn Val Leu His Phe Phe Asn Ala Pro Leu Glu Val 
            500                 505                 510         


Thr Glu Glu Asn Phe Phe Glu Ile Cys Asp Glu Leu Gly Val Lys Arg 
        515                 520                 525             


Pro Ser Ser Val Lys Val Phe Ser Gly Lys Ser Glu Arg Ser Ser Ser 
    530                 535                 540                 


Gly Leu Leu Glu Trp Glu Ser Lys Ser Asp Ala Leu Glu Thr Leu Gly 
545                 550                 555                 560 


Phe Leu Asn His Tyr Gln Met Lys Asn Pro Asn Gly Pro Tyr Pro Tyr 
                565                 570                 575     


Thr Leu Lys Leu Cys Phe Ser Thr Ala Gln His Ala Ser 
            580                 585                 


<210>  5086
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPM__Homo_sapiens__NP_005959

<400>  5086

Met Ala Ala Gly Val Glu Ala Ala Ala Glu Val Ala Ala Thr Glu Ile 
1               5                   10                  15      


Lys Met Glu Glu Glu Ser Gly Ala Pro Gly Val Pro Ser Gly Asn Gly 
            20                  25                  30          


Ala Pro Gly Pro Lys Gly Glu Gly Glu Arg Pro Ala Gln Asn Glu Lys 
        35                  40                  45              


Arg Lys Glu Lys Asn Ile Lys Arg Gly Gly Asn Arg Phe Glu Pro Tyr 
    50                  55                  60                  


Ala Asn Pro Thr Lys Arg Tyr Arg Ala Phe Ile Thr Asn Ile Pro Phe 
65                  70                  75                  80  


Asp Val Lys Trp Gln Ser Leu Lys Asp Leu Val Lys Glu Lys Val Gly 
                85                  90                  95      


Glu Val Thr Tyr Val Glu Leu Leu Met Asp Ala Glu Gly Lys Ser Arg 
            100                 105                 110         


Gly Cys Ala Val Val Glu Phe Lys Met Glu Glu Ser Met Lys Lys Ala 
        115                 120                 125             


Ala Glu Val Leu Asn Lys His Ser Leu Ser Gly Arg Pro Leu Lys Val 
    130                 135                 140                 


Lys Glu Asp Pro Asp Gly Glu His Ala Arg Arg Ala Met Gln Lys Val 
145                 150                 155                 160 


Met Ala Thr Thr Gly Gly Met Gly Met Gly Pro Gly Gly Pro Gly Met 
                165                 170                 175     


Ile Thr Ile Pro Pro Ser Ile Leu Asn Asn Pro Asn Ile Pro Asn Glu 
            180                 185                 190         


Ile Ile His Ala Leu Gln Ala Gly Arg Leu Gly Ser Thr Val Phe Val 
        195                 200                 205             


Ala Asn Leu Asp Tyr Lys Val Gly Trp Lys Lys Leu Lys Glu Val Phe 
    210                 215                 220                 


Ser Met Ala Gly Val Val Val Arg Ala Asp Ile Leu Glu Asp Lys Asp 
225                 230                 235                 240 


Gly Lys Ser Arg Gly Ile Gly Thr Val Thr Phe Glu Gln Ser Ile Glu 
                245                 250                 255     


Ala Val Gln Ala Ile Ser Met Phe Asn Gly Gln Leu Leu Phe Asp Arg 
            260                 265                 270         


Pro Met His Val Lys Met Asp Glu Arg Ala Leu Pro Lys Gly Asp Phe 
        275                 280                 285             


Phe Pro Pro Glu Arg Pro Gln Gln Leu Pro His Gly Leu Gly Gly Ile 
    290                 295                 300                 


Gly Met Gly Leu Gly Pro Gly Gly Gln Pro Ile Asp Ala Asn His Leu 
305                 310                 315                 320 


Asn Lys Gly Ile Gly Met Gly Asn Ile Gly Pro Ala Gly Met Gly Met 
                325                 330                 335     


Glu Gly Ile Gly Phe Gly Ile Asn Lys Met Gly Gly Met Glu Gly Pro 
            340                 345                 350         


Phe Gly Gly Gly Met Glu Asn Met Gly Arg Phe Gly Ser Gly Met Asn 
        355                 360                 365             


Met Gly Arg Ile Asn Glu Ile Leu Ser Asn Ala Leu Lys Arg Gly Glu 
    370                 375                 380                 


Ile Ile Ala Lys Gln Gly Gly Gly Gly Gly Gly Gly Ser Val Pro Gly 
385                 390                 395                 400 


Ile Glu Arg Met Gly Pro Gly Ile Asp Arg Leu Gly Gly Ala Gly Met 
                405                 410                 415     


Glu Arg Met Gly Ala Gly Leu Gly His Gly Met Asp Arg Val Gly Ser 
            420                 425                 430         


Glu Ile Glu Arg Met Gly Leu Val Met Asp Arg Met Gly Ser Val Glu 
        435                 440                 445             


Arg Met Gly Ser Gly Ile Glu Arg Met Gly Pro Leu Gly Leu Asp His 
    450                 455                 460                 


Met Ala Ser Ser Ile Glu Arg Met Gly Gln Thr Met Glu Arg Ile Gly 
465                 470                 475                 480 


Ser Gly Val Glu Arg Met Gly Ala Gly Met Gly Phe Gly Leu Glu Arg 
                485                 490                 495     


Met Ala Ala Pro Ile Asp Arg Val Gly Gln Thr Ile Glu Arg Met Gly 
            500                 505                 510         


Ser Gly Val Glu Arg Met Gly Pro Ala Ile Glu Arg Met Gly Leu Ser 
        515                 520                 525             


Met Glu Arg Met Val Pro Ala Gly Met Gly Ala Gly Leu Glu Arg Met 
    530                 535                 540                 


Gly Pro Val Met Asp Arg Met Ala Thr Gly Leu Glu Arg Met Gly Ala 
545                 550                 555                 560 


Asn Asn Leu Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu 
                565                 570                 575     


Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu Glu Arg Met 
            580                 585                 590         


Gly Pro Ala Met Gly Pro Ala Leu Gly Ala Gly Ile Glu Arg Met Gly 
        595                 600                 605             


Leu Ala Met Gly Gly Gly Gly Gly Ala Ser Phe Asp Arg Ala Ile Glu 
    610                 615                 620                 


Met Glu Arg Gly Asn Phe Gly Gly Ser Phe Ala Gly Ser Phe Gly Gly 
625                 630                 635                 640 


Ala Gly Gly His Ala Pro Gly Val Ala Arg Lys Ala Cys Gln Ile Phe 
                645                 650                 655     


Val Arg Asn Leu Pro Phe Asp Phe Thr Trp Lys Met Leu Lys Asp Lys 
            660                 665                 670         


Phe Asn Glu Cys Gly His Val Leu Tyr Ala Asp Ile Lys Met Glu Asn 
        675                 680                 685             


Gly Lys Ser Lys Gly Cys Gly Val Val Lys Phe Glu Ser Pro Glu Val 
    690                 695                 700                 


Ala Glu Arg Ala Cys Arg Met Met Asn Gly Met Lys Leu Ser Gly Arg 
705                 710                 715                 720 


Glu Ile Asp Val Arg Ile Asp Arg Asn Ala 
                725                 730 


<210>  5087
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPR__Homo_sapiens__NP_001284549

<400>  5087

Met Ala Asn Gln Val Asn Gly Asn Ala Val Gln Leu Lys Glu Glu Glu 
1               5                   10                  15      


Glu Pro Met Asp Thr Ser Ser Val Thr His Thr Glu His Tyr Lys Thr 
            20                  25                  30          


Leu Ile Glu Ala Gly Leu Pro Gln Lys Val Ala Glu Arg Leu Asp Glu 
        35                  40                  45              


Ile Phe Gln Thr Gly Leu Val Ala Tyr Val Asp Leu Asp Glu Arg Ala 
    50                  55                  60                  


Ile Asp Ala Leu Arg Glu Phe Asn Glu Glu Gly Ala Leu Ser Val Leu 
65                  70                  75                  80  


Gln Gln Phe Lys Glu Ser Asp Leu Ser His Val Gln Asn Lys Ser Ala 
                85                  90                  95      


Phe Leu Cys Gly Val Met Lys Thr Tyr Arg Gln Arg Glu Lys Gln Gly 
            100                 105                 110         


Ser Lys Val Gln Glu Ser Thr Lys Gly Pro Asp Glu Ala Lys Ile Lys 
        115                 120                 125             


Val Phe Val Gly Lys Ile Pro Arg Asp Leu Tyr Glu Asp Glu Leu Val 
    130                 135                 140                 


Pro Leu Phe Glu Lys Ala Gly Pro Ile Trp Asp Leu Arg Leu Met Met 
145                 150                 155                 160 


Asp Pro Leu Ser Gly Gln Asn Arg Gly Tyr Ala Phe Ile Thr Phe Cys 
                165                 170                 175     


Gly Lys Glu Ala Ala Gln Glu Ala Val Lys Leu Cys Asp Ser Tyr Glu 
            180                 185                 190         


Ile Arg Pro Gly Lys His Leu Gly Val Cys Ile Ser Val Ala Asn Asn 
        195                 200                 205             


Arg Leu Phe Val Gly Ser Ile Pro Lys Asn Lys Thr Lys Glu Asn Ile 
    210                 215                 220                 


Leu Glu Glu Phe Ser Lys Val Thr Glu Gly Leu Val Asp Val Ile Leu 
225                 230                 235                 240 


Tyr His Gln Pro Asp Asp Lys Lys Lys Asn Arg Gly Phe Cys Phe Leu 
                245                 250                 255     


Glu Tyr Glu Asp His Lys Ser Ala Ala Gln Ala Arg Arg Arg Leu Met 
            260                 265                 270         


Ser Gly Lys Val Lys Val Trp Gly Asn Val Val Thr Val Glu Trp Ala 
        275                 280                 285             


Asp Pro Val Glu Glu Pro Asp Pro Glu Val Met Ala Lys Val Lys Val 
    290                 295                 300                 


Leu Phe Val Arg Asn Leu Ala Thr Thr Val Thr Glu Glu Ile Leu Glu 
305                 310                 315                 320 


Lys Ser Phe Ser Glu Phe Gly Lys Leu Glu Arg Val Lys Lys Leu Lys 
                325                 330                 335     


Asp Tyr Ala Phe Val His Phe Glu Asp Arg Gly Ala Ala Val Lys Ala 
            340                 345                 350         


Met Asp Glu Met Asn Gly Lys Glu Ile Glu Gly Glu Glu Ile Glu Ile 
        355                 360                 365             


Val Leu Ala Lys Pro Pro Asp Lys Lys Arg Lys Glu Arg Gln Ala Ala 
    370                 375                 380                 


Arg Gln Ala Ser Arg Ser Thr Ala Tyr Glu Asp Tyr Tyr Tyr His Pro 
385                 390                 395                 400 


Pro Pro Arg Met Pro Pro Pro Ile Arg Gly Arg Gly Arg Gly Gly Gly 
                405                 410                 415     


Arg Gly Gly Tyr Gly Tyr Pro Pro Asp Tyr Tyr Gly Tyr Glu Asp Tyr 
            420                 425                 430         


Tyr Asp Asp Tyr Tyr Gly Tyr Asp Tyr His Asp Tyr Arg Gly Gly Tyr 
        435                 440                 445             


Glu Asp Pro Tyr Tyr Gly Tyr Asp Asp Gly Tyr Ala Val Arg Gly Arg 
    450                 455                 460                 


Gly Gly Gly Arg Gly Gly Arg Gly Ala Pro Pro Pro Pro Arg Gly Arg 
465                 470                 475                 480 


Gly Ala Pro Pro Pro Arg Gly Arg Ala Gly Tyr Ser Gln Arg Gly Ala 
                485                 490                 495     


Pro Leu Gly Pro Pro Arg Gly Ser Arg Gly Gly Arg Gly Gly Pro Ala 
            500                 505                 510         


Gln Gln Gln Arg Gly Arg Gly Ser Arg Gly Ser Arg Gly Asn Arg Gly 
        515                 520                 525             


Gly Asn Val Gly Gly Lys Arg Lys Ala Asp Gly Tyr Asn Gln Pro Asp 
    530                 535                 540                 


Ser Lys Arg Arg Gln Thr Asn Asn Gln Gln Asn Trp Gly Ser Gln Pro 
545                 550                 555                 560 


Ile Ala Gln Gln Pro Leu Gln Gln Gly Gly Asp Tyr Ser Gly Asn Tyr 
                565                 570                 575     


Gly Tyr Asn Asn Asp Asn Gln Glu Phe Tyr Gln Asp Thr Tyr Gly Gln 
            580                 585                 590         


Gln Trp Lys 
        595 


<210>  5088
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPU__Homo_sapiens__NP_004492

<400>  5088

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15      


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30          


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45              


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60                  


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80  


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95      


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110         


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125             


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140                 


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160 


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175     


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190         


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205             


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220                 


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240 


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255     


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270         


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285             


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300                 


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320 


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335     


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350         


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365             


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380                 


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400 


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415     


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430         


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445             


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460                 


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480 


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495     


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510         


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525             


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540                 


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560 


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575     


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590         


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605             


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620                 


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640 


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655     


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670         


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685             


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Ala 
    690                 695                 700                 


Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met Pro Gln Arg 
705                 710                 715                 720 


Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro Tyr Pro Arg 
                725                 730                 735     


Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg Gly Asn Tyr 
            740                 745                 750         


Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln Asn Phe Arg 
        755                 760                 765             


Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln Gly Tyr Asn 
    770                 775                 780                 


Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp Ser Gln His 
785                 790                 795                 800 


Tyr His Gln Gly Tyr Tyr 
                805     


<210>  5089
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNRNPUL1__Homo_sapiens__NP_008971

<400>  5089

Met Asp Val Arg Arg Leu Lys Val Asn Glu Leu Arg Glu Glu Leu Gln 
1               5                   10                  15      


Arg Arg Gly Leu Asp Thr Arg Gly Leu Lys Ala Glu Leu Ala Glu Arg 
            20                  25                  30          


Leu Gln Ala Ala Leu Glu Ala Glu Glu Pro Asp Asp Glu Arg Glu Leu 
        35                  40                  45              


Asp Ala Asp Asp Glu Pro Gly Arg Pro Gly His Ile Asn Glu Glu Val 
    50                  55                  60                  


Glu Thr Glu Gly Gly Ser Glu Leu Glu Gly Thr Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Pro Gly Leu Gln Pro His Ala Glu Pro Gly Gly Tyr Ser Gly Pro Asp 
                85                  90                  95      


Gly His Tyr Ala Met Asp Asn Ile Thr Arg Gln Asn Gln Phe Tyr Asp 
            100                 105                 110         


Thr Gln Val Ile Lys Gln Glu Asn Glu Ser Gly Tyr Glu Arg Arg Pro 
        115                 120                 125             


Leu Glu Met Glu Gln Gln Gln Ala Tyr Arg Pro Glu Met Lys Thr Glu 
    130                 135                 140                 


Met Lys Gln Gly Ala Pro Thr Ser Phe Leu Pro Pro Glu Ala Ser Gln 
145                 150                 155                 160 


Leu Lys Pro Asp Arg Gln Gln Phe Gln Ser Arg Lys Arg Pro Tyr Glu 
                165                 170                 175     


Glu Asn Arg Gly Arg Gly Tyr Phe Glu His Arg Glu Asp Arg Arg Gly 
            180                 185                 190         


Arg Ser Pro Gln Pro Pro Ala Glu Glu Asp Glu Asp Asp Phe Asp Asp 
        195                 200                 205             


Thr Leu Val Ala Ile Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Val 
    210                 215                 220                 


Ala Arg Asp Arg Ser Ser Gly Tyr Pro Leu Thr Ile Glu Gly Phe Ala 
225                 230                 235                 240 


Tyr Leu Trp Ser Gly Ala Arg Ala Ser Tyr Gly Val Arg Arg Gly Arg 
                245                 250                 255     


Val Cys Phe Glu Met Lys Ile Asn Glu Glu Ile Ser Val Lys His Leu 
            260                 265                 270         


Pro Ser Thr Glu Pro Asp Pro His Val Val Arg Ile Gly Trp Ser Leu 
        275                 280                 285             


Asp Ser Cys Ser Thr Gln Leu Gly Glu Glu Pro Phe Ser Tyr Gly Tyr 
    290                 295                 300                 


Gly Gly Thr Gly Lys Lys Ser Thr Asn Ser Arg Phe Glu Asn Tyr Gly 
305                 310                 315                 320 


Asp Lys Phe Ala Glu Asn Asp Val Ile Gly Cys Phe Ala Asp Phe Glu 
                325                 330                 335     


Cys Gly Asn Asp Val Glu Leu Ser Phe Thr Lys Asn Gly Lys Trp Met 
            340                 345                 350         


Gly Ile Ala Phe Arg Ile Gln Lys Glu Ala Leu Gly Gly Gln Ala Leu 
        355                 360                 365             


Tyr Pro His Val Leu Val Lys Asn Cys Ala Val Glu Phe Asn Phe Gly 
    370                 375                 380                 


Gln Arg Ala Glu Pro Tyr Cys Ser Val Leu Pro Gly Phe Thr Phe Ile 
385                 390                 395                 400 


Gln His Leu Pro Leu Ser Glu Arg Ile Arg Gly Thr Val Gly Pro Lys 
                405                 410                 415     


Ser Lys Ala Glu Cys Glu Ile Leu Met Met Val Gly Leu Pro Ala Ala 
            420                 425                 430         


Gly Lys Thr Thr Trp Ala Ile Lys His Ala Ala Ser Asn Pro Ser Lys 
        435                 440                 445             


Lys Tyr Asn Ile Leu Gly Thr Asn Ala Ile Met Asp Lys Met Arg Val 
    450                 455                 460                 


Met Gly Leu Arg Arg Gln Arg Asn Tyr Ala Gly Arg Trp Asp Val Leu 
465                 470                 475                 480 


Ile Gln Gln Ala Thr Gln Cys Leu Asn Arg Leu Ile Gln Ile Ala Ala 
                485                 490                 495     


Arg Lys Lys Arg Asn Tyr Ile Leu Asp Gln Thr Asn Val Tyr Gly Ser 
            500                 505                 510         


Ala Gln Arg Arg Lys Met Arg Pro Phe Glu Gly Phe Gln Arg Lys Ala 
        515                 520                 525             


Ile Val Ile Cys Pro Thr Asp Glu Asp Leu Lys Asp Arg Thr Ile Lys 
    530                 535                 540                 


Arg Thr Asp Glu Glu Gly Lys Asp Val Pro Asp His Ala Val Leu Glu 
545                 550                 555                 560 


Met Lys Ala Asn Phe Thr Leu Pro Asp Val Gly Asp Phe Leu Asp Glu 
                565                 570                 575     


Val Leu Phe Ile Glu Leu Gln Arg Glu Glu Ala Asp Lys Leu Val Arg 
            580                 585                 590         


Gln Tyr Asn Glu Glu Gly Arg Lys Ala Gly Pro Pro Pro Glu Lys Arg 
        595                 600                 605             


Phe Asp Asn Arg Gly Gly Gly Gly Phe Arg Gly Arg Gly Gly Gly Gly 
    610                 615                 620                 


Gly Phe Gln Arg Tyr Glu Asn Arg Gly Pro Pro Gly Gly Asn Arg Gly 
625                 630                 635                 640 


Gly Phe Gln Asn Arg Gly Gly Gly Ser Gly Gly Gly Gly Asn Tyr Arg 
                645                 650                 655     


Gly Gly Phe Asn Arg Ser Gly Gly Gly Gly Tyr Ser Gln Asn Arg Trp 
            660                 665                 670         


Gly Asn Asn Asn Arg Asp Asn Asn Asn Ser Asn Asn Arg Gly Ser Tyr 
        675                 680                 685             


Asn Arg Ala Pro Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro 
    690                 695                 700                 


Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro Ser Tyr Ser Pro Ala 
705                 710                 715                 720 


Arg Asn Pro Pro Gly Ala Ser Thr Tyr Asn Lys Asn Ser Asn Ile Pro 
                725                 730                 735     


Gly Ser Ser Ala Asn Thr Ser Thr Pro Thr Val Ser Ser Tyr Ser Pro 
            740                 745                 750         


Pro Gln Pro Ser Tyr Ser Gln Pro Pro Tyr Asn Gln Gly Gly Tyr Ser 
        755                 760                 765             


Gln Gly Tyr Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Tyr 
    770                 775                 780                 


Asn Tyr Gly Ser Tyr Gly Gly Tyr Asn Pro Ala Pro Tyr Thr Pro Pro 
785                 790                 795                 800 


Pro Pro Pro Thr Ala Gln Thr Tyr Pro Gln Pro Ser Tyr Asn Gln Tyr 
                805                 810                 815     


Gln Gln Tyr Ala Gln Gln Trp Asn Gln Tyr Tyr Gln Asn Gln Gly Gln 
            820                 825                 830         


Trp Pro Pro Tyr Tyr Gly Asn Tyr Asp Tyr Gly Ser Tyr Ser Gly Asn 
        835                 840                 845             


Thr Gln Gly Gly Thr Ser Thr Gln 
    850                 855     


<210>  5090
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOGA1__Homo_sapiens__NP_001128142

<400>  5090

Met Leu Gly Pro Gln Val Trp Ser Ser Val Arg Gln Gly Leu Ser Arg 
1               5                   10                  15      


Ser Leu Ser Arg Asn Val Gly Val Trp Ala Ser Gly Glu Gly Lys Lys 
            20                  25                  30          


Val Asp Ile Ala Gly Ile Tyr Pro Pro Val Thr Thr Pro Phe Thr Ala 
        35                  40                  45              


Thr Ala Glu Val Asp Tyr Gly Lys Leu Glu Glu Asn Leu His Lys Leu 
    50                  55                  60                  


Gly Thr Phe Pro Phe Arg Gly Ala Val Gly Gly Val Cys Ala Leu Ala 
65                  70                  75                  80  


Asn Val Leu Gly Ala Gln Val Cys Gln Leu Glu Arg Leu Cys Cys Thr 
                85                  90                  95      


Gly Gln Trp Glu Asp Ala Gln Lys Leu Gln His Arg Leu Ile Glu Pro 
            100                 105                 110         


Asn Ala Ala Val Thr Arg Arg Phe Gly Ile Pro Gly Leu Lys Lys Ile 
        115                 120                 125             


Met Asp Trp Phe Gly Tyr Tyr Gly Gly Pro Cys Arg Ala Pro Leu Gln 
    130                 135                 140                 


Glu Leu Ser Pro Ala Glu Glu Glu Ala Leu Arg Met Asp Phe Thr Ser 
145                 150                 155                 160 


Asn Gly Trp Leu 
                


<210>  5091
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOMER1__Homo_sapiens__NP_001264006

<400>  5091

Met Gly Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val Phe Gln Ile 
1               5                   10                  15      


Asp Pro Asn Thr Lys Lys Asn Trp Val Pro Thr Ser Lys His Ala Val 
            20                  25                  30          


Thr Val Ser Tyr Phe Tyr Asp Ser Thr Arg Asn Val Tyr Arg Ile Ile 
        35                  40                  45              


Ser Leu Asp Gly Ser Lys Ala Ile Ile Asn Ser Thr Ile Thr Pro Asn 
    50                  55                  60                  


Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
65                  70                  75                  80  


Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ser Ser Glu His His Leu 
                85                  90                  95      


Ser Lys Val Thr Glu Leu Glu Cys Val Ser Ser Gln Ala Asn Ala Val 
            100                 105                 110         


His Thr His Lys Thr Glu Leu Asn Gln Thr Ile Gln Glu Leu Glu Glu 
        115                 120                 125             


Thr Leu Lys Leu Lys Glu Glu Glu Ile Glu Arg Leu Lys Gln Glu Ile 
    130                 135                 140                 


Asp Asn Ala Arg Glu Leu Gln Glu Gln Arg Asp Ser Leu Thr Gln Lys 
145                 150                 155                 160 


Leu Gln Glu Val Glu Ile Arg Asn Lys Asp Leu Glu Gly Gln Leu Ser 
                165                 170                 175     


Asp Leu Glu Gln Arg Leu Glu Lys Ser Gln Asn Glu Gln Glu Ala Phe 
            180                 185                 190         


Arg Asn Asn Leu Lys Thr Leu Leu Glu Ile Leu Asp Gly Lys Ile Phe 
        195                 200                 205             


Glu Leu Thr Glu Leu Arg Asp Asn Leu Ala Lys Leu Leu Glu Cys Ser 
    210                 215                 220                 


<210>  5092
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOMER2__Homo_sapiens__NP_004830

<400>  5092

Met Gly Glu Gln Pro Ile Phe Thr Thr Arg Ala His Val Phe Gln Ile 
1               5                   10                  15      


Asp Pro Asn Thr Lys Lys Asn Trp Met Pro Ala Ser Lys Gln Ala Val 
            20                  25                  30          


Thr Val Ser Tyr Phe Tyr Asp Val Thr Arg Asn Ser Tyr Arg Ile Ile 
        35                  40                  45              


Ser Val Asp Gly Ala Lys Val Ile Ile Asn Ser Thr Ile Thr Pro Asn 
    50                  55                  60                  


Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp Ala Asp Ser 
65                  70                  75                  80  


Arg Ala Asn Thr Val Phe Gly Leu Gly Phe Ser Ser Glu Gln Gln Leu 
                85                  90                  95      


Thr Lys Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala Ala Lys Ile 
            100                 105                 110         


Ala Lys Asp Lys Thr Gln Glu Lys Ile Glu Thr Ser Ser Asn His Ser 
        115                 120                 125             


Gln Ala Ser Ser Val Asn Gly Thr Asp Asp Glu Lys Ala Ser His Ala 
    130                 135                 140                 


Gly Pro Ala Asn Thr His Leu Lys Ser Glu Asn Asp Lys Leu Lys Ile 
145                 150                 155                 160 


Ala Leu Thr Gln Ser Ala Ala Asn Val Lys Lys Trp Glu Ile Glu Leu 
                165                 170                 175     


Gln Thr Leu Arg Glu Ser Asn Ala Arg Leu Thr Thr Ala Leu Gln Glu 
            180                 185                 190         


Ser Ala Ala Ser Val Glu Gln Trp Lys Arg Gln Phe Ser Ile Cys Arg 
        195                 200                 205             


Asp Glu Asn Asp Arg Leu Arg Asn Lys Ile Asp Glu Leu Glu Glu Gln 
    210                 215                 220                 


Cys Ser Glu Ile Asn Arg Glu Lys Glu Lys Asn Thr Gln Leu Lys Arg 
225                 230                 235                 240 


Arg Ile Glu Glu Leu Glu Ala Glu Leu Arg Glu Lys Glu Thr Glu Leu 
                245                 250                 255     


Lys Asp Leu Arg Lys Gln Ser Glu Ile Ile Pro Gln Leu Met Ser Glu 
            260                 265                 270         


Cys Glu Tyr Val Ser Glu Lys Leu Glu Ala Ala Glu Arg Asp Asn Gln 
        275                 280                 285             


Asn Leu Glu Asp Lys Val Arg Ser Leu Lys Thr Asp Ile Glu Glu Ser 
    290                 295                 300                 


Lys Tyr Arg Gln Arg His Leu Lys Val Glu Leu Lys Ser Phe Leu Glu 
305                 310                 315                 320 


Val Leu Asp Gly Lys Ile Asp Asp Leu His Asp Phe Arg Arg Gly Leu 
                325                 330                 335     


Ser Lys Leu Gly Thr Asp Asn 
            340             


<210>  5093
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOMER3__Homo_sapiens__NP_001139193

<400>  5093

Met Ser Thr Ala Arg Glu Gln Pro Ile Phe Ser Thr Arg Ala His Val 
1               5                   10                  15      


Phe Gln Ile Asp Pro Ala Thr Lys Arg Asn Trp Ile Pro Ala Gly Lys 
            20                  25                  30          


His Ala Leu Thr Val Ser Tyr Phe Tyr Asp Ala Thr Arg Asn Val Tyr 
        35                  40                  45              


Arg Ile Ile Ser Ile Gly Gly Ala Lys Ala Ile Ile Asn Ser Thr Val 
    50                  55                  60                  


Thr Pro Asn Met Thr Phe Thr Lys Thr Ser Gln Lys Phe Gly Gln Trp 
65                  70                  75                  80  


Ala Asp Ser Arg Ala Asn Thr Val Tyr Gly Leu Gly Phe Ala Ser Glu 
                85                  90                  95      


Gln His Leu Thr Gln Phe Ala Glu Lys Phe Gln Glu Val Lys Glu Ala 
            100                 105                 110         


Ala Arg Leu Ala Arg Glu Lys Ser Gln Asp Gly Gly Glu Leu Thr Ser 
        115                 120                 125             


Pro Ala Leu Gly Leu Ala Ser His Gln Val Pro Pro Ser Pro Leu Val 
    130                 135                 140                 


Ser Ala Asn Gly Pro Gly Glu Glu Lys Leu Phe Arg Ser Gln Ser Ala 
145                 150                 155                 160 


Asp Ala Pro Gly Pro Thr Glu Arg Glu Arg Leu Lys Lys Met Leu Ser 
                165                 170                 175     


Glu Gly Ser Val Gly Glu Val Gln Trp Glu Ala Glu Phe Phe Ala Leu 
            180                 185                 190         


Gln Asp Ser Asn Asn Lys Leu Ala Gly Ala Leu Arg Glu Ala Asn Ala 
        195                 200                 205             


Ala Ala Ala Gln Trp Arg Gln Gln Leu Glu Ala Gln Arg Ala Glu Ala 
    210                 215                 220                 


Glu Arg Leu Arg Gln Arg Val Ala Glu Leu Glu Ala Gln Ala Ala Ser 
225                 230                 235                 240 


Glu Val Thr Pro Thr Gly Glu Lys Glu Gly Leu Gly Gln Gly Gln Ser 
                245                 250                 255     


Leu Glu Gln Leu Glu Ala Leu Val Gln Thr Lys Asp Gln Glu Ile Gln 
            260                 265                 270         


Thr Leu Lys Ser Gln Thr Gly Gly Pro Arg Glu Ala Leu Glu Ala Ala 
        275                 280                 285             


Glu Arg Glu Glu Thr Gln Gln Lys Val Gln Thr Arg Asn Ala Glu Leu 
    290                 295                 300                 


Glu His Gln Leu Arg Ala Met Glu Arg Ser Leu Glu Glu Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Glu Arg Ala Arg Ala Glu Val Gly Arg Ala Ala Gln Leu Leu 
                325                 330                 335     


Asp Val Ser Leu Phe Glu Leu Ser Glu Leu Arg Glu Gly Leu Ala Arg 
            340                 345                 350         


Leu Ala Glu Ala Ala Pro 
        355             


<210>  5094
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOMEZ__Homo_sapiens__NP_065885

<400>  5094

Met Val Arg Gly Trp Glu Pro Pro Pro Gly Leu Asp Cys Ala Ile Ser 
1               5                   10                  15      


Glu Gly His Lys Ser Glu Gly Thr Met Pro Pro Asn Lys Glu Ala Ser 
            20                  25                  30          


Gly Leu Ser Ser Ser Pro Ala Gly Leu Ile Cys Leu Pro Pro Ile Ser 
        35                  40                  45              


Glu Glu Leu Gln Leu Val Trp Thr Gln Ala Ala Gln Thr Ser Glu Leu 
    50                  55                  60                  


Asp Ser Asn Glu His Leu Leu Lys Thr Phe Ser Tyr Phe Pro Tyr Pro 
65                  70                  75                  80  


Ser Leu Ala Asp Ile Ala Leu Leu Cys Leu Arg Tyr Gly Leu Gln Met 
                85                  90                  95      


Glu Lys Val Lys Thr Trp Phe Met Ala Gln Arg Leu Arg Cys Gly Ile 
            100                 105                 110         


Ser Trp Ser Ser Glu Glu Ile Glu Glu Thr Arg Ala Arg Val Val Tyr 
        115                 120                 125             


Arg Arg Asp Gln Leu His Phe Lys Ser Leu Leu Ser Phe Thr His His 
    130                 135                 140                 


Ala Gly Arg Pro Pro Glu Glu Val Pro Pro Pro Pro Val Pro Ala Pro 
145                 150                 155                 160 


Glu Gln Val Gly Ile Gly Ile Gly Pro Pro Thr Leu Ser Lys Pro Thr 
                165                 170                 175     


Gln Thr Lys Gly Leu Lys Val Glu Pro Glu Glu Pro Ser Gln Met Pro 
            180                 185                 190         


Pro Leu Pro Gln Ser His Gln Lys Leu Lys Glu Ser Leu Met Thr Pro 
        195                 200                 205             


Gly Ser Gly Ala Phe Pro Tyr Gln Ser Asp Phe Trp Gln His Leu Gln 
    210                 215                 220                 


Ser Ser Gly Leu Ser Lys Glu Gln Ala Gly Arg Gly Pro Asn Gln Ser 
225                 230                 235                 240 


His Gly Ile Gly Thr Ala Ser Trp Asn His Ser Thr Thr Val Pro Gln 
                245                 250                 255     


Pro Gln Ala Arg Asp Lys Pro Pro Pro Ile Ala Leu Ile Ala Ser Ser 
            260                 265                 270         


Cys Lys Glu Glu Ser Ala Ser Ser Val Thr Pro Ser Ser Ser Ser Thr 
        275                 280                 285             


Ser Ser Ser Phe Gln Val Leu Ala Asn Gly Ala Thr Ala Ala Ser Lys 
    290                 295                 300                 


Pro Leu Gln Pro Leu Gly Cys Val Pro Gln Ser Val Ser Pro Ser Glu 
305                 310                 315                 320 


Gln Ala Leu Pro Pro His Leu Glu Pro Ala Trp Pro Gln Gly Leu Arg 
                325                 330                 335     


His Asn Ser Val Pro Gly Arg Val Gly Pro Thr Glu Tyr Leu Ser Pro 
            340                 345                 350         


Asp Met Gln Arg Gln Arg Lys Thr Lys Arg Lys Thr Lys Glu Gln Leu 
        355                 360                 365             


Ala Ile Leu Lys Ser Phe Phe Leu Gln Cys Gln Trp Ala Arg Arg Glu 
    370                 375                 380                 


Asp Tyr Gln Lys Leu Glu Gln Ile Thr Gly Leu Pro Arg Pro Glu Ile 
385                 390                 395                 400 


Ile Gln Trp Phe Gly Asp Thr Arg Tyr Ala Leu Lys His Gly Gln Leu 
                405                 410                 415     


Lys Trp Phe Arg Asp Asn Ala Val Pro Gly Ala Pro Ser Phe Gln Asp 
            420                 425                 430         


Pro Ala Ile Pro Thr Pro Pro Pro Ser Thr Arg Ser Leu Asn Glu Arg 
        435                 440                 445             


Ala Glu Thr Pro Pro Leu Pro Ile Pro Pro Pro Pro Pro Asp Ile Gln 
    450                 455                 460                 


Pro Leu Glu Arg Tyr Trp Ala Ala His Gln Gln Leu Arg Glu Thr Asp 
465                 470                 475                 480 


Ile Pro Gln Leu Ser Gln Ala Ser Arg Leu Ser Thr Gln Gln Val Leu 
                485                 490                 495     


Asp Trp Phe Asp Ser Arg Leu Pro Gln Pro Ala Glu Val Val Val Cys 
            500                 505                 510         


Leu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Pro Glu Asp Asp 
        515                 520                 525             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp Asp 
    530                 535                 540                 


Asp Val Ile Ile Gln Asp 
545                 550 


<210>  5095
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOOK2__Homo_sapiens__NP_001093646

<400>  5095

Met Ser Val Asp Lys Ala Glu Leu Cys Gly Ser Leu Leu Thr Trp Leu 
1               5                   10                  15      


Gln Thr Phe His Val Pro Ser Pro Cys Ala Ser Pro Gln Asp Leu Ser 
            20                  25                  30          


Ser Gly Leu Ala Val Ala Tyr Val Leu Asn Gln Ile Asp Pro Ser Trp 
        35                  40                  45              


Phe Asn Glu Ala Trp Leu Gln Gly Ile Ser Glu Asp Pro Gly Pro Asn 
    50                  55                  60                  


Trp Lys Leu Lys Val Ser Asn Leu Lys Met Val Leu Arg Ser Leu Val 
65                  70                  75                  80  


Glu Tyr Ser Gln Asp Val Leu Ala His Pro Val Ser Glu Glu His Leu 
                85                  90                  95      


Pro Asp Val Ser Leu Ile Gly Glu Phe Ser Asp Pro Ala Glu Leu Gly 
            100                 105                 110         


Lys Leu Leu Gln Leu Val Leu Gly Cys Ala Ile Ser Cys Glu Lys Lys 
        115                 120                 125             


Gln Asp His Ile Gln Arg Ile Met Thr Leu Glu Glu Ser Val Gln His 
    130                 135                 140                 


Val Val Met Glu Ala Ile Gln Glu Leu Met Thr Lys Asp Thr Pro Asp 
145                 150                 155                 160 


Ser Leu Ser Pro Glu Thr Tyr Gly Asn Phe Asp Ser Gln Ser Arg Arg 
                165                 170                 175     


Tyr Tyr Phe Leu Ser Glu Glu Ala Glu Glu Gly Asp Glu Leu Gln Gln 
            180                 185                 190         


Arg Cys Leu Asp Leu Glu Arg Gln Leu Met Leu Leu Ser Glu Glu Lys 
        195                 200                 205             


Gln Ser Leu Ala Gln Glu Asn Ala Gly Leu Arg Glu Arg Met Gly Arg 
    210                 215                 220                 


Pro Glu Gly Glu Gly Thr Pro Gly Leu Thr Ala Lys Lys Leu Leu Leu 
225                 230                 235                 240 


Leu Gln Ser Gln Leu Glu Gln Leu Gln Glu Glu Asn Phe Arg Leu Glu 
                245                 250                 255     


Ser Gly Arg Glu Asp Glu Arg Leu Arg Cys Ala Glu Leu Glu Arg Glu 
            260                 265                 270         


Val Ala Glu Leu Gln His Arg Asn Gln Ala Leu Thr Ser Leu Ala Gln 
        275                 280                 285             


Glu Ala Gln Ala Leu Lys Asp Glu Met Asp Glu Leu Arg Gln Ser Ser 
    290                 295                 300                 


Glu Arg Ala Gly Gln Leu Glu Ala Thr Leu Thr Ser Cys Arg Arg Arg 
305                 310                 315                 320 


Leu Gly Glu Leu Arg Glu Leu Arg Arg Gln Val Arg Gln Leu Glu Glu 
                325                 330                 335     


Arg Asn Ala Gly His Ala Glu Arg Thr Arg Gln Leu Glu Asp Glu Leu 
            340                 345                 350         


Arg Arg Ala Gly Ser Leu Arg Ala Gln Leu Glu Ala Gln Arg Arg Gln 
        355                 360                 365             


Val Gln Glu Leu Gln Gly Gln Arg Gln Glu Glu Ala Met Lys Ala Glu 
    370                 375                 380                 


Lys Trp Leu Phe Glu Cys Arg Asn Leu Glu Glu Lys Tyr Glu Ser Val 
385                 390                 395                 400 


Thr Lys Glu Lys Glu Arg Leu Leu Ala Glu Arg Asp Ser Leu Arg Glu 
                405                 410                 415     


Ala Asn Glu Glu Leu Arg Cys Ala Gln Leu Gln Pro Arg Gly Leu Thr 
            420                 425                 430         


Gln Ala Asp Pro Ser Leu Asp Pro Thr Ser Thr Pro Val Asp Asn Leu 
        435                 440                 445             


Ala Ala Glu Ile Leu Pro Ala Glu Leu Arg Glu Thr Leu Leu Arg Leu 
    450                 455                 460                 


Gln Leu Glu Asn Lys Arg Leu Cys Arg Gln Glu Ala Ala Asp Arg Glu 
465                 470                 475                 480 


Arg Gln Glu Glu Leu Gln Arg His Leu Glu Asp Ala Asn Arg Ala Arg 
                485                 490                 495     


His Gly Leu Glu Thr Gln His Arg Leu Asn Gln Gln Gln Leu Ser Glu 
            500                 505                 510         


Leu Arg Ala Gln Val Glu Asp Leu Gln Lys Ala Leu Gln Glu Gln Gly 
        515                 520                 525             


Gly Lys Thr Glu Asp Ser Ile Leu Leu Lys Arg Lys Leu Glu Glu His 
    530                 535                 540                 


Leu Gln Lys Leu His Glu Ala Asp Leu Glu Leu Gln Arg Lys Arg Glu 
545                 550                 555                 560 


Tyr Ile Glu Glu Leu Glu Pro Pro Thr Asp Ser Ser Thr Ala Arg Arg 
                565                 570                 575     


Ile Glu Glu Leu Gln His Asn Leu Gln Lys Lys Asp Ala Asp Leu Arg 
            580                 585                 590         


Ala Met Glu Glu Arg Tyr Arg Arg Tyr Val Asp Lys Ala Arg Met Val 
        595                 600                 605             


Met Gln Thr Met Glu Pro Lys Gln Arg Pro Ala Ala Gly Ala Pro Pro 
    610                 615                 620                 


Glu Leu His Ser Leu Arg Thr Gln Leu Arg Glu Arg Asp Val Arg Ile 
625                 630                 635                 640 


Arg His Leu Glu Met Asp Phe Glu Lys Ser Arg Ser Gln Arg Glu Gln 
                645                 650                 655     


Glu Glu Lys Leu Leu Ile Ser Ala Trp Tyr Asn Met Gly Met Ala Leu 
            660                 665                 670         


Gln Gln Arg Ala Gly Glu Glu Arg Ala Pro Ala His Ala Gln Ser Phe 
        675                 680                 685             


Leu Ala Gln Gln Arg Leu Ala Thr Asn Ser Arg Arg Gly Pro Leu Gly 
    690                 695                 700                 


Arg Leu Ala Ser Leu Asn Leu Arg Pro Thr Asp Lys His 
705                 710                 715         


<210>  5096
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOOK3__Homo_sapiens__NP_115786

<400>  5096

Met Phe Ser Val Glu Ser Leu Glu Arg Ala Glu Leu Cys Glu Ser Leu 
1               5                   10                  15      


Leu Thr Trp Ile Gln Thr Phe Asn Val Asp Ala Pro Cys Gln Thr Val 
            20                  25                  30          


Glu Asp Leu Thr Asn Gly Val Val Met Ala Gln Val Leu Gln Lys Ile 
        35                  40                  45              


Asp Pro Ala Tyr Phe Asp Glu Asn Trp Leu Asn Arg Ile Lys Thr Glu 
    50                  55                  60                  


Val Gly Asp Asn Trp Arg Leu Lys Ile Ser Asn Leu Lys Lys Ile Leu 
65                  70                  75                  80  


Lys Gly Ile Leu Asp Tyr Asn His Glu Ile Leu Gly Gln Gln Ile Asn 
                85                  90                  95      


Asp Phe Thr Leu Pro Asp Val Asn Leu Ile Gly Glu His Ser Asp Ala 
            100                 105                 110         


Ala Glu Leu Gly Arg Met Leu Gln Leu Ile Leu Gly Cys Ala Val Asn 
        115                 120                 125             


Cys Glu Gln Lys Gln Glu Tyr Ile Gln Ala Ile Met Met Met Glu Glu 
    130                 135                 140                 


Ser Val Gln His Val Val Met Thr Ala Ile Gln Glu Leu Met Ser Lys 
145                 150                 155                 160 


Glu Ser Pro Val Ser Ala Gly Asn Asp Ala Tyr Val Asp Leu Asp Arg 
                165                 170                 175     


Gln Leu Lys Lys Thr Thr Glu Glu Leu Asn Glu Ala Leu Ser Ala Lys 
            180                 185                 190         


Glu Glu Ile Ala Gln Arg Cys His Glu Leu Asp Met Gln Val Ala Ala 
        195                 200                 205             


Leu Gln Glu Glu Lys Ser Ser Leu Leu Ala Glu Asn Gln Val Leu Met 
    210                 215                 220                 


Glu Arg Leu Asn Gln Ser Asp Ser Ile Glu Asp Pro Asn Ser Pro Ala 
225                 230                 235                 240 


Gly Arg Arg His Leu Gln Leu Gln Thr Gln Leu Glu Gln Leu Gln Glu 
                245                 250                 255     


Glu Thr Phe Arg Leu Glu Ala Ala Lys Asp Asp Tyr Arg Ile Arg Cys 
            260                 265                 270         


Glu Glu Leu Glu Lys Glu Ile Ser Glu Leu Arg Gln Gln Asn Asp Glu 
        275                 280                 285             


Leu Thr Thr Leu Ala Asp Glu Ala Gln Ser Leu Lys Asp Glu Ile Asp 
    290                 295                 300                 


Val Leu Arg His Ser Ser Asp Lys Val Ser Lys Leu Glu Gly Gln Val 
305                 310                 315                 320 


Glu Ser Tyr Lys Lys Lys Leu Glu Asp Leu Gly Asp Leu Arg Arg Gln 
                325                 330                 335     


Val Lys Leu Leu Glu Glu Lys Asn Thr Met Tyr Met Gln Asn Thr Val 
            340                 345                 350         


Ser Leu Glu Glu Glu Leu Arg Lys Ala Asn Ala Ala Arg Ser Gln Leu 
        355                 360                 365             


Glu Thr Tyr Lys Arg Gln Val Val Glu Leu Gln Asn Arg Leu Ser Glu 
    370                 375                 380                 


Glu Ser Lys Lys Ala Asp Lys Leu Asp Phe Glu Tyr Lys Arg Leu Lys 
385                 390                 395                 400 


Glu Lys Val Asp Ser Leu Gln Lys Glu Lys Asp Arg Leu Arg Thr Glu 
                405                 410                 415     


Arg Asp Ser Leu Lys Glu Thr Ile Glu Glu Leu Arg Cys Val Gln Ala 
            420                 425                 430         


Gln Glu Gly Gln Leu Thr Thr Gln Gly Leu Met Pro Leu Gly Ser Gln 
        435                 440                 445             


Glu Ser Ser Asp Ser Leu Ala Ala Glu Ile Val Thr Pro Glu Ile Arg 
    450                 455                 460                 


Glu Lys Leu Ile Arg Leu Gln His Glu Asn Lys Met Leu Lys Leu Asn 
465                 470                 475                 480 


Gln Glu Gly Ser Asp Asn Glu Lys Ile Ala Leu Leu Gln Ser Leu Leu 
                485                 490                 495     


Asp Asp Ala Asn Leu Arg Lys Asn Glu Leu Glu Thr Glu Asn Arg Leu 
            500                 505                 510         


Val Asn Gln Arg Leu Leu Glu Val Gln Ser Gln Val Glu Glu Leu Gln 
        515                 520                 525             


Lys Ser Leu Gln Asp Gln Gly Ser Lys Ala Glu Asp Ser Val Leu Leu 
    530                 535                 540                 


Lys Lys Lys Leu Glu Glu His Leu Glu Lys Leu His Glu Ala Asn Asn 
545                 550                 555                 560 


Glu Leu Gln Lys Lys Arg Ala Ile Ile Glu Asp Leu Glu Pro Arg Phe 
                565                 570                 575     


Asn Asn Ser Ser Leu Lys Ile Glu Glu Leu Gln Glu Ala Leu Arg Lys 
            580                 585                 590         


Lys Glu Glu Glu Met Lys Gln Met Glu Glu Arg Tyr Lys Lys Tyr Leu 
        595                 600                 605             


Glu Lys Ala Lys Ser Val Ile Arg Thr Leu Asp Pro Lys Gln Asn Gln 
    610                 615                 620                 


Gly Ala Ala Pro Glu Ile Gln Ala Leu Lys Asn Gln Leu Gln Glu Arg 
625                 630                 635                 640 


Asp Arg Leu Phe His Ser Leu Glu Lys Glu Tyr Glu Lys Thr Lys Ser 
                645                 650                 655     


Gln Arg Glu Met Glu Glu Lys Tyr Ile Val Ser Ala Trp Tyr Asn Met 
            660                 665                 670         


Gly Met Thr Leu His Lys Lys Ala Ala Glu Asp Arg Leu Ala Ser Thr 
        675                 680                 685             


Gly Ser Gly Gln Ser Phe Leu Ala Arg Gln Arg Gln Ala Thr Ser Ser 
    690                 695                 700                 


Arg Arg Ser Tyr Pro Gly His Val Gln Pro Ala Thr Ala Arg 
705                 710                 715             


<210>  5097
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOPX__Homo_sapiens__NP_001138931

<400>  5097

Met Ser Ala Glu Thr Ala Ser Gly Pro Thr Glu Asp Gln Val Glu Ile 
1               5                   10                  15      


Leu Glu Tyr Asn Phe Asn Lys Val Asp Lys His Pro Asp Ser Thr Thr 
            20                  25                  30          


Leu Cys Leu Ile Ala Ala Glu Ala Gly Leu Ser Glu Glu Glu Thr Gln 
        35                  40                  45              


Lys Trp Phe Lys Gln Arg Leu Ala Lys Trp Arg Arg Ser Glu Gly Leu 
    50                  55                  60                  


Pro Ser Glu Cys Arg Ser Val Thr Asp 
65                  70              


<210>  5098
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HORMAD2__Homo_sapiens__NP_689723

<400>  5098

Met Ala Thr Ala Gln Leu Ser His Cys Ile Thr Ile His Lys Ala Ser 
1               5                   10                  15      


Lys Glu Thr Val Phe Pro Ser Gln Ile Thr Asn Glu His Glu Ser Leu 
            20                  25                  30          


Lys Met Val Lys Lys Leu Phe Ala Thr Ser Ile Ser Cys Ile Thr Tyr 
        35                  40                  45              


Leu Arg Gly Leu Phe Pro Glu Ser Ser Tyr Gly Glu Arg His Leu Asp 
    50                  55                  60                  


Asp Leu Ser Leu Lys Ile Leu Arg Glu Asp Lys Lys Cys Pro Gly Ser 
65                  70                  75                  80  


Leu His Ile Ile Arg Trp Ile Gln Gly Cys Phe Asp Ala Leu Glu Lys 
                85                  90                  95      


Arg Tyr Leu Arg Met Ala Val Leu Thr Leu Tyr Thr Asp Pro Met Gly 
            100                 105                 110         


Ser Glu Lys Val Thr Glu Met Tyr Gln Phe Lys Phe Lys Tyr Thr Lys 
        115                 120                 125             


Glu Gly Ala Thr Met Asp Phe Asp Ser His Ser Ser Ser Thr Ser Phe 
    130                 135                 140                 


Glu Ser Gly Thr Asn Asn Glu Asp Ile Lys Lys Ala Ser Val Leu Leu 
145                 150                 155                 160 


Ile Arg Lys Leu Tyr Ile Leu Met Gln Asp Leu Glu Pro Leu Pro Asn 
                165                 170                 175     


Asn Val Val Leu Thr Met Lys Leu His Tyr Tyr Asn Ala Val Thr Pro 
            180                 185                 190         


His Asp Tyr Gln Pro Leu Gly Phe Lys Glu Gly Val Asn Ser His Phe 
        195                 200                 205             


Leu Leu Phe Asp Lys Glu Pro Ile Asn Val Gln Val Gly Phe Val Ser 
    210                 215                 220                 


Thr Gly Phe His Ser Met Lys Val Lys Val Met Thr Glu Ala Thr Lys 
225                 230                 235                 240 


Val Ile Asp Leu Glu Asn Asn Leu Phe Arg Glu Asn Ser Thr Thr Glu 
                245                 250                 255     


Ile Ala His Gln Gly Leu Asp Cys Asp Glu Glu Glu Glu Cys Asn Asp 
            260                 265                 270         


His Ile Gln Arg Met Asn Phe Val Cys Ser Gln Gln Ser Ser Glu Cys 
        275                 280                 285             


Ser Arg Lys Lys Arg Lys Val Ser Glu Pro Val Lys Val Phe Ile Pro 
    290                 295                 300                 


Asn Arg Lys 
305         


<210>  5099
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA10__Homo_sapiens__NP_061824

<400>  5099

Met Ser Ala Arg Lys Gly Tyr Leu Leu Pro Ser Pro Asn Tyr Pro Thr 
1               5                   10                  15      


Thr Met Ser Cys Ser Glu Ser Pro Ala Ala Asn Ser Phe Leu Val Asp 
            20                  25                  30          


Ser Leu Ile Ser Ser Gly Arg Gly Glu Ala Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Ala Gly Gly Gly Gly Gly Gly Gly Tyr Tyr Ala His Gly Gly Val Tyr 
    50                  55                  60                  


Leu Pro Pro Ala Ala Asp Leu Pro Tyr Gly Leu Gln Ser Cys Gly Leu 
65                  70                  75                  80  


Phe Pro Thr Leu Gly Gly Lys Arg Asn Glu Ala Ala Ser Pro Gly Ser 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Leu Gly Pro Gly Ala His Gly Tyr Gly Pro 
            100                 105                 110         


Ser Pro Ile Asp Leu Trp Leu Asp Ala Pro Arg Ser Cys Arg Met Glu 
        115                 120                 125             


Pro Pro Asp Gly Pro Pro Pro Pro Pro Gln Gln Gln Pro Pro Pro Pro 
    130                 135                 140                 


Pro Gln Pro Pro Gln Pro Ala Pro Gln Ala Thr Ser Cys Ser Phe Ala 
145                 150                 155                 160 


Gln Asn Ile Lys Glu Glu Ser Ser Tyr Cys Leu Tyr Asp Ser Ala Asp 
                165                 170                 175     


Lys Cys Pro Lys Val Ser Ala Thr Ala Ala Glu Leu Ala Pro Phe Pro 
            180                 185                 190         


Arg Gly Pro Pro Pro Asp Gly Cys Ala Leu Gly Thr Ser Ser Gly Val 
        195                 200                 205             


Pro Val Pro Gly Tyr Phe Arg Leu Ser Gln Ala Tyr Gly Thr Ala Lys 
    210                 215                 220                 


Gly Tyr Gly Ser Gly Gly Gly Gly Ala Gln Gln Leu Gly Ala Gly Pro 
225                 230                 235                 240 


Phe Pro Ala Gln Pro Pro Gly Arg Gly Phe Asp Leu Pro Pro Ala Leu 
                245                 250                 255     


Ala Ser Gly Ser Ala Asp Ala Ala Arg Lys Glu Arg Ala Leu Asp Ser 
            260                 265                 270         


Pro Pro Pro Pro Thr Leu Ala Cys Gly Ser Gly Gly Gly Ser Gln Gly 
        275                 280                 285             


Asp Glu Glu Ala His Ala Ser Ser Ser Ala Ala Glu Glu Leu Ser Pro 
    290                 295                 300                 


Ala Pro Ser Glu Ser Ser Lys Ala Ser Pro Glu Lys Asp Ser Leu Gly 
305                 310                 315                 320 


Asn Ser Lys Gly Glu Asn Ala Ala Asn Trp Leu Thr Ala Lys Ser Gly 
                325                 330                 335     


Arg Lys Lys Arg Cys Pro Tyr Thr Lys His Gln Thr Leu Glu Leu Glu 
            340                 345                 350         


Lys Glu Phe Leu Phe Asn Met Tyr Leu Thr Arg Glu Arg Arg Leu Glu 
        355                 360                 365             


Ile Ser Arg Ser Val His Leu Thr Asp Arg Gln Val Lys Ile Trp Phe 
    370                 375                 380                 


Gln Asn Arg Arg Met Lys Leu Lys Lys Met Asn Arg Glu Asn Arg Ile 
385                 390                 395                 400 


Arg Glu Leu Thr Ala Asn Phe Asn Phe Ser 
                405                 410 


<210>  5100
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA11__Homo_sapiens__NP_005514

<400>  5100

Met Asp Phe Asp Glu Arg Gly Pro Cys Ser Ser Asn Met Tyr Leu Pro 
1               5                   10                  15      


Ser Cys Thr Tyr Tyr Val Ser Gly Pro Asp Phe Ser Ser Leu Pro Ser 
            20                  25                  30          


Phe Leu Pro Gln Thr Pro Ser Ser Arg Pro Met Thr Tyr Ser Tyr Ser 
        35                  40                  45              


Ser Asn Leu Pro Gln Val Gln Pro Val Arg Glu Val Thr Phe Arg Glu 
    50                  55                  60                  


Tyr Ala Ile Glu Pro Ala Thr Lys Trp His Pro Arg Gly Asn Leu Ala 
65                  70                  75                  80  


His Cys Tyr Ser Ala Glu Glu Leu Val His Arg Asp Cys Leu Gln Ala 
                85                  90                  95      


Pro Ser Ala Ala Gly Val Pro Gly Asp Val Leu Ala Lys Ser Ser Ala 
            100                 105                 110         


Asn Val Tyr His His Pro Thr Pro Ala Val Ser Ser Asn Phe Tyr Ser 
        115                 120                 125             


Thr Val Gly Arg Asn Gly Val Leu Pro Gln Ala Phe Asp Gln Phe Phe 
    130                 135                 140                 


Glu Thr Ala Tyr Gly Thr Pro Glu Asn Leu Ala Ser Ser Asp Tyr Pro 
145                 150                 155                 160 


Gly Asp Lys Ser Ala Glu Lys Gly Pro Pro Ala Ala Thr Ala Thr Ser 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Thr Gly Ala Pro Ala Thr Ser Ser Ser 
            180                 185                 190         


Asp Ser Gly Gly Gly Gly Gly Cys Arg Glu Thr Ala Ala Ala Ala Glu 
        195                 200                 205             


Glu Lys Glu Arg Arg Arg Arg Pro Glu Ser Ser Ser Ser Pro Glu Ser 
    210                 215                 220                 


Ser Ser Gly His Thr Glu Asp Lys Ala Gly Gly Ser Ser Gly Gln Arg 
225                 230                 235                 240 


Thr Arg Lys Lys Arg Cys Pro Tyr Thr Lys Tyr Gln Ile Arg Glu Leu 
                245                 250                 255     


Glu Arg Glu Phe Phe Phe Ser Val Tyr Ile Asn Lys Glu Lys Arg Leu 
            260                 265                 270         


Gln Leu Ser Arg Met Leu Asn Leu Thr Asp Arg Gln Val Lys Ile Trp 
        275                 280                 285             


Phe Gln Asn Arg Arg Met Lys Glu Lys Lys Ile Asn Arg Asp Arg Leu 
    290                 295                 300                 


Gln Tyr Tyr Ser Ala Asn Pro Leu Leu 
305                 310             


<210>  5101
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA13__Homo_sapiens__XP_011513646

<400>  5101

Met Thr Ala Ser Val Leu Leu His Pro Arg Trp Ile Glu Pro Thr Val 
1               5                   10                  15      


Met Phe Leu Tyr Asp Asn Gly Gly Gly Leu Val Ala Asp Glu Leu Asn 
            20                  25                  30          


Lys Asn Met Glu Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Gly Ala Gly Gly Gly Gly Phe Pro His Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Gly Gly Asn Phe Ser Val Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Asn Gln Cys Arg Asn Leu Met Ala His Pro Ala Pro 
                85                  90                  95      


Leu Ala Pro Gly Ala Ala Ser Ala Tyr Ser Ser Ala Pro Gly Glu Ala 
            100                 105                 110         


Pro Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ser Ser Ser Gly Gly Pro Gly Pro Ala Gly Pro 
    130                 135                 140                 


Ala Gly Ala Glu Ala Ala Lys Gln Cys Ser Pro Cys Ser Ala Ala Ala 
145                 150                 155                 160 


Gln Ser Ser Ser Gly Pro Ala Ala Leu Pro Tyr Gly Tyr Phe Gly Ser 
                165                 170                 175     


Gly Tyr Tyr Pro Cys Ala Arg Met Gly Pro His Pro Asn Ala Ile Lys 
            180                 185                 190         


Ser Cys Ala Gln Pro Ala Ser Ala Ala Ala Ala Ala Ala Phe Ala Asp 
        195                 200                 205             


Lys Tyr Met Asp Thr Ala Gly Pro Ala Ala Glu Glu Phe Ser Ser Arg 
    210                 215                 220                 


Ala Lys Glu Phe Ala Phe Tyr His Gln Gly Tyr Ala Ala Gly Pro Tyr 
225                 230                 235                 240 


His His His Gln Pro Met Pro Gly Tyr Leu Asp Met Pro Val Val Pro 
                245                 250                 255     


Gly Leu Gly Gly Pro Gly Glu Ser Arg His Glu Pro Leu Gly Leu Pro 
            260                 265                 270         


Met Glu Ser Tyr Gln Pro Trp Ala Leu Pro Asn Gly Trp Asn Gly Gln 
        275                 280                 285             


Met Tyr Cys Pro Lys Glu Gln Ala Gln Pro Pro His Leu Trp Lys Ser 
    290                 295                 300                 


Thr Leu Pro Asp Val Val Ser His Pro Ser Asp Ala Ser Ser Tyr Arg 
305                 310                 315                 320 


Arg Gly Arg Lys Lys Arg Val Pro Tyr Thr Lys Val Gln Leu Lys Glu 
                325                 330                 335     


Leu Glu Arg Glu Tyr Ala Thr Asn Lys Phe Ile Thr Lys Asp Lys Arg 
            340                 345                 350         


Arg Arg Ile Ser Ala Thr Thr Asn Leu Ser Glu Arg Gln Val Thr Ile 
        355                 360                 365             


Trp Phe Gln Asn Arg Arg Val Lys Glu Lys Lys Val Ile Asn Lys Leu 
    370                 375                 380                 


Lys Thr Thr Ser 
385             


<210>  5102
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA1__Homo_sapiens__NP_005513

<400>  5102

Met Asp Asn Ala Arg Met Asn Ser Phe Leu Glu Tyr Pro Ile Leu Ser 
1               5                   10                  15      


Ser Gly Asp Ser Gly Thr Cys Ser Ala Arg Ala Tyr Pro Ser Asp His 
            20                  25                  30          


Arg Ile Thr Thr Phe Gln Ser Cys Ala Val Ser Ala Asn Ser Cys Gly 
        35                  40                  45              


Gly Asp Asp Arg Phe Leu Val Gly Arg Gly Val Gln Ile Gly Ser Pro 
    50                  55                  60                  


His His His His His His His His His His Pro Gln Pro Ala Thr Tyr 
65                  70                  75                  80  


Gln Thr Ser Gly Asn Leu Gly Val Ser Tyr Ser His Ser Ser Cys Gly 
                85                  90                  95      


Pro Ser Tyr Gly Ser Gln Asn Phe Ser Ala Pro Tyr Ser Pro Tyr Ala 
            100                 105                 110         


Leu Asn Gln Glu Ala Asp Val Ser Gly Gly Tyr Pro Gln Cys Ala Pro 
        115                 120                 125             


Ala Val Tyr Ser Gly Asn Leu Ser Ser Pro Met Val Gln His His His 
    130                 135                 140                 


His His Gln Gly Tyr Ala Gly Gly Ala Val Gly Ser Pro Gln Tyr Ile 
145                 150                 155                 160 


His His Ser Tyr Gly Gln Glu His Gln Ser Leu Ala Leu Ala Thr Tyr 
                165                 170                 175     


Asn Asn Ser Leu Ser Pro Leu His Ala Ser His Gln Glu Ala Cys Arg 
            180                 185                 190         


Ser Pro Ala Ser Glu Thr Ser Ser Pro Ala Gln Thr Phe Asp Trp Met 
        195                 200                 205             


Lys Val Lys Arg Asn Pro Pro Lys Thr Gly Lys Val Gly Glu Tyr Gly 
    210                 215                 220                 


Tyr Leu Gly Gln Pro Asn Ala Val Arg Thr Asn Phe Thr Thr Lys Gln 
225                 230                 235                 240 


Leu Thr Glu Leu Glu Lys Glu Phe His Phe Asn Lys Tyr Leu Thr Arg 
                245                 250                 255     


Ala Arg Arg Val Glu Ile Ala Ala Ser Leu Gln Leu Asn Glu Thr Gln 
            260                 265                 270         


Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Gln Lys Lys Arg Glu 
        275                 280                 285             


Lys Glu Gly Leu Leu Pro Ile Ser Pro Ala Thr Pro Pro Gly Asn Asp 
    290                 295                 300                 


Glu Lys Ala Glu Glu Ser Ser Glu Lys Ser Ser Ser Ser Pro Cys Val 
305                 310                 315                 320 


Pro Ser Pro Gly Ser Ser Thr Ser Asp Thr Leu Thr Thr Ser His 
                325                 330                 335 


<210>  5103
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA2__Homo_sapiens__NP_006726

<400>  5103

Met Asn Tyr Glu Phe Glu Arg Glu Ile Gly Phe Ile Asn Ser Gln Pro 
1               5                   10                  15      


Ser Leu Ala Glu Cys Leu Thr Ser Phe Pro Pro Val Ala Asp Thr Phe 
            20                  25                  30          


Gln Ser Ser Ser Ile Lys Thr Ser Thr Leu Ser His Ser Thr Leu Ile 
        35                  40                  45              


Pro Pro Pro Phe Glu Gln Thr Ile Pro Ser Leu Asn Pro Gly Ser His 
    50                  55                  60                  


Pro Arg His Gly Ala Gly Gly Arg Pro Lys Pro Ser Pro Ala Gly Ser 
65                  70                  75                  80  


Arg Gly Ser Pro Val Pro Ala Gly Ala Leu Gln Pro Pro Glu Tyr Pro 
                85                  90                  95      


Trp Met Lys Glu Lys Lys Ala Ala Lys Lys Thr Ala Leu Leu Pro Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Thr Ala Ala Ala Thr Gly Pro Ala Cys Leu Ser 
        115                 120                 125             


His Lys Glu Ser Leu Glu Ile Ala Asp Gly Ser Gly Gly Gly Ser Arg 
    130                 135                 140                 


Arg Leu Arg Thr Ala Tyr Thr Asn Thr Gln Leu Leu Glu Leu Glu Lys 
145                 150                 155                 160 


Glu Phe His Phe Asn Lys Tyr Leu Cys Arg Pro Arg Arg Val Glu Ile 
                165                 170                 175     


Ala Ala Leu Leu Asp Leu Thr Glu Arg Gln Val Lys Val Trp Phe Gln 
            180                 185                 190         


Asn Arg Arg Met Lys His Lys Arg Gln Thr Gln Cys Lys Glu Asn Gln 
        195                 200                 205             


Asn Ser Glu Gly Lys Cys Lys Ser Leu Glu Asp Ser Glu Lys Val Glu 
    210                 215                 220                 


Glu Asp Glu Glu Glu Lys Thr Leu Phe Glu Gln Ala Leu Ser Val Ser 
225                 230                 235                 240 


Gly Ala Leu Leu Glu Arg Glu Gly Tyr Thr Phe Gln Gln Asn Ala Leu 
                245                 250                 255     


Ser Gln Gln Gln Ala Pro Asn Gly His Asn Gly Asp Ser Gln Ser Phe 
            260                 265                 270         


Pro Val Ser Pro Leu Thr Ser Asn Glu Lys Asn Leu Lys His Phe Gln 
        275                 280                 285             


His Gln Ser Pro Thr Val Pro Asn Cys Leu Ser Thr Met Gly Gln Asn 
    290                 295                 300                 


Cys Gly Ala Gly Leu Asn Asn Asp Ser Pro Glu Ala Leu Glu Val Pro 
305                 310                 315                 320 


Ser Leu Gln Asp Phe Ser Val Phe Ser Thr Asp Ser Cys Leu Gln Leu 
                325                 330                 335     


Ser Asp Ala Val Ser Pro Ser Leu Pro Gly Ser Leu Asp Ser Pro Val 
            340                 345                 350         


Asp Ile Ser Ala Asp Ser Leu Asp Phe Phe Thr Asp Thr Leu Thr Thr 
        355                 360                 365             


Ile Asp Leu Gln His Leu Asn Tyr 
    370                 375     


<210>  5104
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA3__Homo_sapiens__XP_005249788

<400>  5104

Met Gln Lys Ala Thr Tyr Tyr Asp Ser Ser Ala Ile Tyr Gly Gly Tyr 
1               5                   10                  15      


Pro Tyr Gln Ala Ala Asn Gly Phe Ala Tyr Asn Ala Asn Gln Gln Pro 
            20                  25                  30          


Tyr Pro Ala Ser Ala Ala Leu Gly Ala Asp Gly Glu Tyr His Arg Pro 
        35                  40                  45              


Ala Cys Ser Leu Gln Ser Pro Ser Ser Ala Gly Gly His Pro Lys Ala 
    50                  55                  60                  


His Glu Leu Ser Glu Ala Cys Leu Arg Thr Leu Ser Ala Pro Pro Ser 
65                  70                  75                  80  


Gln Pro Pro Ser Leu Gly Glu Pro Pro Leu His Pro Pro Pro Pro Gln 
                85                  90                  95      


Ala Ala Pro Pro Ala Pro Gln Pro Pro Gln Pro Ala Pro Gln Pro Pro 
            100                 105                 110         


Ala Pro Thr Pro Ala Ala Pro Pro Pro Pro Ser Ser Ala Ser Pro Pro 
        115                 120                 125             


Gln Asn Ala Ser Asn Asn Pro Thr Pro Ala Asn Ala Ala Lys Ser Pro 
    130                 135                 140                 


Leu Leu Asn Ser Pro Thr Val Ala Lys Gln Ile Phe Pro Trp Met Lys 
145                 150                 155                 160 


Glu Ser Arg Gln Asn Thr Lys Gln Lys Thr Ser Ser Ser Ser Ser Gly 
                165                 170                 175     


Glu Ser Cys Ala Gly Asp Lys Ser Pro Pro Gly Gln Ala Ser Ser Lys 
            180                 185                 190         


Arg Ala Arg Thr Ala Tyr Thr Ser Ala Gln Leu Val Glu Leu Glu Lys 
        195                 200                 205             


Glu Phe His Phe Asn Arg Tyr Leu Cys Arg Pro Arg Arg Val Glu Met 
    210                 215                 220                 


Ala Asn Leu Leu Asn Leu Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln 
225                 230                 235                 240 


Asn Arg Arg Met Lys Tyr Lys Lys Asp Gln Lys Gly Lys Gly Met Leu 
                245                 250                 255     


Thr Ser Ser Gly Gly Gln Ser Pro Ser Arg Ser Pro Val Pro Pro Gly 
            260                 265                 270         


Ala Gly Gly Tyr Leu Asn Ser Met His Ser Leu Val Asn Ser Val Pro 
        275                 280                 285             


Tyr Glu Pro Gln Ser Pro Pro Pro Phe Ser Lys Pro Pro Gln Gly Thr 
    290                 295                 300                 


Tyr Gly Leu Pro Pro Ala Ser Tyr Pro Ala Ser Leu Pro Ser Cys Ala 
305                 310                 315                 320 


Pro Pro Pro Pro Pro Gln Lys Arg Tyr Thr Ala Ala Gly Ala Gly Ala 
                325                 330                 335     


Gly Gly Thr Pro Asp Tyr Asp Pro His Ala His Gly Leu Gln Gly Asn 
            340                 345                 350         


Gly Ser Tyr Gly Thr Pro His Ile Gln Gly Ser Pro Val Phe Val Gly 
        355                 360                 365             


Gly Ser Tyr Val Glu Pro Met Ser Asn Ser Gly Pro Ala Leu Phe Gly 
    370                 375                 380                 


Leu Thr His Leu Pro His Ala Ala Ser Gly Ala Met Asp Tyr Gly Gly 
385                 390                 395                 400 


Ala Gly Pro Leu Gly Ser Gly His His His Gly Pro Gly Pro Gly Glu 
                405                 410                 415     


Pro His Pro Thr Tyr Thr Asp Leu Thr Gly His His Pro Ser Gln Gly 
            420                 425                 430         


Arg Ile Gln Glu Ala Pro Lys Leu Thr His Leu 
        435                 440             


<210>  5105
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA4__Homo_sapiens__NP_002132

<400>  5105

Met Thr Met Ser Ser Phe Leu Ile Asn Ser Asn Tyr Ile Glu Pro Lys 
1               5                   10                  15      


Phe Pro Pro Phe Glu Glu Tyr Ala Gln His Ser Gly Ser Gly Gly Ala 
            20                  25                  30          


Asp Gly Gly Pro Gly Gly Gly Pro Gly Tyr Gln Gln Pro Pro Ala Pro 
        35                  40                  45              


Pro Thr Gln His Leu Pro Leu Gln Gln Pro Gln Leu Pro His Ala Gly 
    50                  55                  60                  


Gly Gly Arg Glu Pro Thr Ala Ser Tyr Tyr Ala Pro Arg Thr Ala Arg 
65                  70                  75                  80  


Glu Pro Ala Tyr Pro Ala Ala Ala Leu Tyr Pro Ala His Gly Ala Ala 
                85                  90                  95      


Asp Thr Ala Tyr Pro Tyr Gly Tyr Arg Gly Gly Ala Ser Pro Gly Arg 
            100                 105                 110         


Pro Pro Gln Pro Glu Gln Pro Pro Ala Gln Ala Lys Gly Pro Ala His 
        115                 120                 125             


Gly Leu His Ala Ser His Val Leu Gln Pro Gln Leu Pro Pro Pro Leu 
    130                 135                 140                 


Gln Pro Arg Ala Val Pro Pro Ala Ala Pro Arg Arg Cys Glu Ala Ala 
145                 150                 155                 160 


Pro Ala Thr Pro Gly Val Pro Ala Gly Gly Ser Ala Pro Ala Cys Pro 
                165                 170                 175     


Leu Leu Leu Ala Asp Lys Ser Pro Leu Gly Leu Lys Gly Lys Glu Pro 
            180                 185                 190         


Val Val Tyr Pro Trp Met Lys Lys Ile His Val Ser Ala Val Asn Pro 
        195                 200                 205             


Ser Tyr Asn Gly Gly Glu Pro Lys Arg Ser Arg Thr Ala Tyr Thr Arg 
    210                 215                 220                 


Gln Gln Val Leu Glu Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu 
225                 230                 235                 240 


Thr Arg Arg Arg Arg Ile Glu Ile Ala His Thr Leu Cys Leu Ser Glu 
                245                 250                 255     


Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
            260                 265                 270         


Asp His Lys Leu Pro Asn Thr Lys Met Arg Ser Ser Asn Ser Ala Ser 
        275                 280                 285             


Ala Ser Ala Gly Pro Pro Gly Lys Ala Gln Thr Gln Ser Pro His Leu 
    290                 295                 300                 


His Pro His Pro His Pro Ser Thr Ser Thr Pro Val Pro Ser Ser Ile 
305                 310                 315                 320 


<210>  5106
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA5__Homo_sapiens__NP_061975

<400>  5106

Met Ser Ser Tyr Phe Val Asn Ser Phe Cys Gly Arg Tyr Pro Asn Gly 
1               5                   10                  15      


Pro Asp Tyr Gln Leu His Asn Tyr Gly Asp His Ser Ser Val Ser Glu 
            20                  25                  30          


Gln Phe Arg Asp Ser Ala Ser Met His Ser Gly Arg Tyr Gly Tyr Gly 
        35                  40                  45              


Tyr Asn Gly Met Asp Leu Ser Val Gly Arg Ser Gly Ser Gly His Phe 
    50                  55                  60                  


Gly Ser Gly Glu Arg Ala Arg Ser Tyr Ala Ala Ser Ala Ser Ala Ala 
65                  70                  75                  80  


Pro Ala Glu Pro Arg Tyr Ser Gln Pro Ala Thr Ser Thr His Ser Pro 
                85                  90                  95      


Gln Pro Asp Pro Leu Pro Cys Ser Ala Val Ala Pro Ser Pro Gly Ser 
            100                 105                 110         


Asp Ser His His Gly Gly Lys Asn Ser Leu Ser Asn Ser Ser Gly Ala 
        115                 120                 125             


Ser Ala Asp Ala Gly Ser Thr His Ile Ser Ser Arg Glu Gly Val Gly 
    130                 135                 140                 


Thr Ala Ser Gly Ala Glu Glu Asp Ala Pro Ala Ser Ser Glu Gln Ala 
145                 150                 155                 160 


Ser Ala Gln Ser Glu Pro Ser Pro Ala Pro Pro Ala Gln Pro Gln Ile 
                165                 170                 175     


Tyr Pro Trp Met Arg Lys Leu His Ile Ser His Asp Asn Ile Gly Gly 
            180                 185                 190         


Pro Glu Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu 
        195                 200                 205             


Glu Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg 
    210                 215                 220                 


Arg Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys 
225                 230                 235                 240 


Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu 
                245                 250                 255     


Lys Ser Met Ser Met Ala Ala Ala Gly Gly Ala Phe Arg Pro 
            260                 265                 270 


<210>  5107
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA6__Homo_sapiens__NP_076919

<400>  5107

Met Ser Ser Tyr Phe Val Asn Pro Thr Phe Pro Gly Ser Leu Pro Ser 
1               5                   10                  15      


Gly Gln Asp Ser Phe Leu Gly Gln Leu Pro Leu Tyr Gln Ala Gly Tyr 
            20                  25                  30          


Asp Ala Leu Arg Pro Phe Pro Ala Ser Tyr Gly Ala Ser Ser Leu Pro 
        35                  40                  45              


Asp Lys Thr Tyr Thr Ser Pro Cys Phe Tyr Gln Gln Ser Asn Ser Val 
    50                  55                  60                  


Leu Ala Cys Asn Arg Ala Ser Tyr Glu Tyr Gly Ala Ser Cys Phe Tyr 
65                  70                  75                  80  


Ser Asp Lys Asp Leu Ser Gly Ala Ser Pro Ser Gly Ser Gly Lys Gln 
                85                  90                  95      


Arg Gly Pro Gly Asp Tyr Leu His Phe Ser Pro Glu Gln Gln Tyr Lys 
            100                 105                 110         


Pro Asp Ser Ser Ser Gly Gln Gly Lys Ala Leu His Asp Glu Gly Ala 
        115                 120                 125             


Asp Arg Lys Tyr Thr Ser Pro Val Tyr Pro Trp Met Gln Arg Met Asn 
    130                 135                 140                 


Ser Cys Ala Gly Ala Val Tyr Gly Ser His Gly Arg Arg Gly Arg Gln 
145                 150                 155                 160 


Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe His Phe 
                165                 170                 175     


Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala Asn Ala Leu 
            180                 185                 190         


Cys Leu Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met 
        195                 200                 205             


Lys Trp Lys Lys Glu Asn Lys Leu Ile Asn Ser Thr Gln Pro Ser Gly 
    210                 215                 220                 


Glu Asp Ser Glu Ala Lys Ala Gly Glu 
225                 230             


<210>  5108
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA7__Homo_sapiens__NP_008827

<400>  5108

Met Ser Ser Ser Tyr Tyr Val Asn Ala Leu Phe Ser Lys Tyr Thr Ala 
1               5                   10                  15      


Gly Ala Ser Leu Phe Gln Asn Ala Glu Pro Thr Ser Cys Ser Phe Ala 
            20                  25                  30          


Pro Asn Ser Gln Arg Ser Gly Tyr Gly Ala Gly Ala Gly Ala Phe Ala 
        35                  40                  45              


Ser Thr Val Pro Gly Leu Tyr Asn Val Asn Ser Pro Leu Tyr Gln Ser 
    50                  55                  60                  


Pro Phe Ala Ser Gly Tyr Gly Leu Gly Ala Asp Ala Tyr Gly Asn Leu 
65                  70                  75                  80  


Pro Cys Ala Ser Tyr Asp Gln Asn Ile Pro Gly Leu Cys Ser Asp Leu 
                85                  90                  95      


Ala Lys Gly Ala Cys Asp Lys Thr Asp Glu Gly Ala Leu His Gly Ala 
            100                 105                 110         


Ala Glu Ala Asn Phe Arg Ile Tyr Pro Trp Met Arg Ser Ser Gly Pro 
        115                 120                 125             


Asp Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu 
    130                 135                 140                 


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
145                 150                 155                 160 


Ile Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile 
                165                 170                 175     


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu His Lys Asp Glu 
            180                 185                 190         


Gly Pro Thr Ala Ala Ala Ala Pro Glu Gly Ala Val Pro Ser Ala Ala 
        195                 200                 205             


Ala Thr Ala Ala Ala Asp Lys Ala Asp Glu Glu Asp Asp Asp Glu Glu 
    210                 215                 220                 


Glu Glu Asp Glu Glu Glu 
225                 230 


<210>  5109
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXA9__Homo_sapiens__NP_689952

<400>  5109

Met Ala Thr Thr Gly Ala Leu Gly Asn Tyr Tyr Val Asp Ser Phe Leu 
1               5                   10                  15      


Leu Gly Ala Asp Ala Ala Asp Glu Leu Ser Val Gly Arg Tyr Ala Pro 
            20                  25                  30          


Gly Thr Leu Gly Gln Pro Pro Arg Gln Ala Ala Thr Leu Ala Glu His 
        35                  40                  45              


Pro Asp Phe Ser Pro Cys Ser Phe Gln Ser Lys Ala Thr Val Phe Gly 
    50                  55                  60                  


Ala Ser Trp Asn Pro Val His Ala Ala Gly Ala Asn Ala Val Pro Ala 
65                  70                  75                  80  


Ala Val Tyr His His His His His His Pro Tyr Val His Pro Gln Ala 
                85                  90                  95      


Pro Val Ala Ala Ala Ala Pro Asp Gly Arg Tyr Met Arg Ser Trp Leu 
            100                 105                 110         


Glu Pro Thr Pro Gly Ala Leu Ser Phe Ala Gly Leu Pro Ser Ser Arg 
        115                 120                 125             


Pro Tyr Gly Ile Lys Pro Glu Pro Leu Ser Ala Arg Arg Gly Asp Cys 
    130                 135                 140                 


Pro Thr Leu Asp Thr His Thr Leu Ser Leu Thr Asp Tyr Ala Cys Gly 
145                 150                 155                 160 


Ser Pro Pro Val Asp Arg Glu Lys Gln Pro Ser Glu Gly Ala Phe Ser 
                165                 170                 175     


Glu Asn Asn Ala Glu Asn Glu Ser Gly Gly Asp Lys Pro Pro Ile Asp 
            180                 185                 190         


Pro Asn Asn Pro Ala Ala Asn Trp Leu His Ala Arg Ser Thr Arg Lys 
        195                 200                 205             


Lys Arg Cys Pro Tyr Thr Lys His Gln Thr Leu Glu Leu Glu Lys Glu 
    210                 215                 220                 


Phe Leu Phe Asn Met Tyr Leu Thr Arg Asp Arg Arg Tyr Glu Val Ala 
225                 230                 235                 240 


Arg Leu Leu Asn Leu Thr Glu Arg Gln Val Lys Ile Trp Phe Gln Asn 
                245                 250                 255     


Arg Arg Met Lys Met Lys Lys Ile Asn Lys Asp Arg Ala Lys Asp Glu 
            260                 265                 270         


<210>  5110
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB13__Homo_sapiens__NP_006352

<400>  5110

Met Glu Pro Gly Asn Tyr Ala Thr Leu Asp Gly Ala Lys Asp Ile Glu 
1               5                   10                  15      


Gly Leu Leu Gly Ala Gly Gly Gly Arg Asn Leu Val Ala His Ser Pro 
            20                  25                  30          


Leu Thr Ser His Pro Ala Ala Pro Thr Leu Met Pro Ala Val Asn Tyr 
        35                  40                  45              


Ala Pro Leu Asp Leu Pro Gly Ser Ala Glu Pro Pro Lys Gln Cys His 
    50                  55                  60                  


Pro Cys Pro Gly Val Pro Gln Gly Thr Ser Pro Ala Pro Val Pro Tyr 
65                  70                  75                  80  


Gly Tyr Phe Gly Gly Gly Tyr Tyr Ser Cys Arg Val Ser Arg Ser Ser 
                85                  90                  95      


Leu Lys Pro Cys Ala Gln Ala Ala Thr Leu Ala Ala Tyr Pro Ala Glu 
            100                 105                 110         


Thr Pro Thr Ala Gly Glu Glu Tyr Pro Ser Arg Pro Thr Glu Phe Ala 
        115                 120                 125             


Phe Tyr Pro Gly Tyr Pro Gly Thr Tyr Gln Pro Met Ala Ser Tyr Leu 
    130                 135                 140                 


Asp Val Ser Val Val Gln Thr Leu Gly Ala Pro Gly Glu Pro Arg His 
145                 150                 155                 160 


Asp Ser Leu Leu Pro Val Asp Ser Tyr Gln Ser Trp Ala Leu Ala Gly 
                165                 170                 175     


Gly Trp Asn Ser Gln Met Cys Cys Gln Gly Glu Gln Asn Pro Pro Gly 
            180                 185                 190         


Pro Phe Trp Lys Ala Ala Phe Ala Asp Ser Ser Gly Gln His Pro Pro 
        195                 200                 205             


Asp Ala Cys Ala Phe Arg Arg Gly Arg Lys Lys Arg Ile Pro Tyr Ser 
    210                 215                 220                 


Lys Gly Gln Leu Arg Glu Leu Glu Arg Glu Tyr Ala Ala Asn Lys Phe 
225                 230                 235                 240 


Ile Thr Lys Asp Lys Arg Arg Lys Ile Ser Ala Ala Thr Ser Leu Ser 
                245                 250                 255     


Glu Arg Gln Ile Thr Ile Trp Phe Gln Asn Arg Arg Val Lys Glu Lys 
            260                 265                 270         


Lys Val Leu Ala Lys Val Lys Asn Ser Ala Thr Pro 
        275                 280                 


<210>  5111
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB1__Homo_sapiens__NP_002135

<400>  5111

Met Asp Tyr Asn Arg Met Asn Ser Phe Leu Glu Tyr Pro Leu Cys Asn 
1               5                   10                  15      


Arg Gly Pro Ser Ala Tyr Ser Ala His Ser Ala Pro Thr Ser Phe Pro 
            20                  25                  30          


Pro Ser Ser Ala Gln Ala Val Asp Ser Tyr Ala Ser Glu Gly Arg Tyr 
        35                  40                  45              


Gly Gly Gly Leu Ser Ser Pro Ala Phe Gln Gln Asn Ser Gly Tyr Pro 
    50                  55                  60                  


Ala Gln Gln Pro Pro Ser Thr Leu Gly Val Pro Phe Pro Ser Ser Ala 
65                  70                  75                  80  


Pro Ser Gly Tyr Ala Pro Ala Ala Cys Ser Pro Ser Tyr Gly Pro Ser 
                85                  90                  95      


Gln Tyr Tyr Pro Leu Gly Gln Ser Glu Gly Asp Gly Gly Tyr Phe His 
            100                 105                 110         


Pro Ser Ser Tyr Gly Ala Gln Leu Gly Gly Leu Ser Asp Gly Tyr Gly 
        115                 120                 125             


Ala Gly Gly Ala Gly Pro Gly Pro Tyr Pro Pro Gln His Pro Pro Tyr 
    130                 135                 140                 


Gly Asn Glu Gln Thr Ala Ser Phe Ala Pro Ala Tyr Ala Asp Leu Leu 
145                 150                 155                 160 


Ser Glu Asp Lys Glu Thr Pro Cys Pro Ser Glu Pro Asn Thr Pro Thr 
                165                 170                 175     


Ala Arg Thr Phe Asp Trp Met Lys Val Lys Arg Asn Pro Pro Lys Thr 
            180                 185                 190         


Ala Lys Val Ser Glu Pro Gly Leu Gly Ser Pro Ser Gly Leu Arg Thr 
        195                 200                 205             


Asn Phe Thr Thr Arg Gln Leu Thr Glu Leu Glu Lys Glu Phe His Phe 
    210                 215                 220                 


Asn Lys Tyr Leu Ser Arg Ala Arg Arg Val Glu Ile Ala Ala Thr Leu 
225                 230                 235                 240 


Glu Leu Asn Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met 
                245                 250                 255     


Lys Gln Lys Lys Arg Glu Arg Glu Glu Gly Arg Val Pro Pro Ala Pro 
            260                 265                 270         


Pro Gly Cys Pro Lys Glu Ala Ala Gly Asp Ala Ser Asp Gln Ser Thr 
        275                 280                 285             


Cys Thr Ser Pro Glu Ala Ser Pro Ser Ser Val Thr Ser 
    290                 295                 300     


<210>  5112
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB2__Homo_sapiens__NP_002136

<400>  5112

Met Asn Phe Glu Phe Glu Arg Glu Ile Gly Phe Ile Asn Ser Gln Pro 
1               5                   10                  15      


Ser Leu Ala Glu Cys Leu Thr Ser Phe Pro Ala Val Leu Glu Thr Phe 
            20                  25                  30          


Gln Thr Ser Ser Ile Lys Glu Ser Thr Leu Ile Pro Pro Pro Pro Pro 
        35                  40                  45              


Phe Glu Gln Thr Phe Pro Ser Leu Gln Pro Gly Ala Ser Thr Leu Gln 
    50                  55                  60                  


Arg Pro Arg Ser Gln Lys Arg Ala Glu Asp Gly Pro Ala Leu Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Leu Pro Ala Ala Pro Pro Ala Pro Glu Phe Pro 
                85                  90                  95      


Trp Met Lys Glu Lys Lys Ser Ala Lys Lys Pro Ser Gln Ser Ala Thr 
            100                 105                 110         


Ser Pro Ser Pro Ala Ala Ser Ala Val Pro Ala Ser Gly Val Gly Ser 
        115                 120                 125             


Pro Ala Asp Gly Leu Gly Leu Pro Glu Ala Gly Gly Gly Gly Ala Arg 
    130                 135                 140                 


Arg Leu Arg Thr Ala Tyr Thr Asn Thr Gln Leu Leu Glu Leu Glu Lys 
145                 150                 155                 160 


Glu Phe His Phe Asn Lys Tyr Leu Cys Arg Pro Arg Arg Val Glu Ile 
                165                 170                 175     


Ala Ala Leu Leu Asp Leu Thr Glu Arg Gln Val Lys Val Trp Phe Gln 
            180                 185                 190         


Asn Arg Arg Met Lys His Lys Arg Gln Thr Gln His Arg Glu Pro Pro 
        195                 200                 205             


Asp Gly Glu Pro Ala Cys Pro Gly Ala Leu Glu Asp Ile Cys Asp Pro 
    210                 215                 220                 


Ala Glu Glu Pro Ala Ala Ser Pro Gly Gly Pro Ser Ala Ser Arg Ala 
225                 230                 235                 240 


Ala Trp Glu Ala Cys Cys His Pro Pro Glu Val Val Pro Gly Ala Leu 
                245                 250                 255     


Ser Ala Asp Pro Arg Pro Leu Ala Val Arg Leu Glu Gly Ala Gly Ala 
            260                 265                 270         


Ser Ser Pro Gly Cys Ala Leu Arg Gly Ala Gly Gly Leu Glu Pro Gly 
        275                 280                 285             


Pro Leu Pro Glu Asp Val Phe Ser Gly Arg Gln Asp Ser Pro Phe Leu 
    290                 295                 300                 


Pro Asp Leu Asn Phe Phe Ala Ala Asp Ser Cys Leu Gln Leu Ser Gly 
305                 310                 315                 320 


Gly Leu Ser Pro Ser Leu Gln Gly Ser Leu Asp Ser Pro Val Pro Phe 
                325                 330                 335     


Ser Glu Glu Glu Leu Asp Phe Phe Thr Ser Thr Leu Cys Ala Ile Asp 
            340                 345                 350         


Leu Gln Phe Pro 
        355     


<210>  5113
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB3__Homo_sapiens__XP_005257339

<400>  5113

Met Lys Glu Ser Arg Gln Thr Ser Lys Leu Lys Asn Asn Ser Pro Gly 
1               5                   10                  15      


Thr Ala Glu Gly Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asp Lys 
        35                  40                  45              


Ser Pro Pro Gly Ser Ala Ala Ser Lys Arg Ala Arg Thr Ala Tyr Thr 
    50                  55                  60                  


Ser Ala Gln Leu Val Glu Leu Glu Lys Glu Phe His Phe Asn Arg Tyr 
65                  70                  75                  80  


Leu Cys Arg Pro Arg Arg Val Glu Met Ala Asn Leu Leu Asn Leu Ser 
                85                  90                  95      


Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Tyr Lys 
            100                 105                 110         


Lys Asp Gln Lys Ala Lys Gly Leu Ala Ser Ser Ser Gly Gly Pro Ser 
        115                 120                 125             


Pro Ala Gly Ser Pro Pro Gln Pro Met Gln Ser Thr Ala Gly Phe Met 
    130                 135                 140                 


Asn Ala Leu His Ser Met Thr Pro Ser Tyr Glu Ser Pro Ser Pro Pro 
145                 150                 155                 160 


Ala Phe Gly Lys Ala His Gln Asn Ala Tyr Ala Leu Pro Ser Asn Tyr 
                165                 170                 175     


Gln Pro Pro Leu Lys Gly Cys Gly Ala Pro Gln Lys Tyr Pro Pro Thr 
            180                 185                 190         


Pro Ala Pro Glu Tyr Glu Pro His Val Leu Gln Ala Asn Gly Gly Ala 
        195                 200                 205             


Tyr Gly Thr Pro Thr Met Gln Gly Ser Pro Val Tyr Val Gly Gly Gly 
    210                 215                 220                 


Gly Tyr Ala Asp Pro Leu Pro Pro Pro Ala Gly Pro Ser Leu Tyr Gly 
225                 230                 235                 240 


Leu Asn His Leu Ser His His Pro Ser Gly Asn Leu Asp Tyr Asn Gly 
                245                 250                 255     


Ala Pro Pro Met Ala Pro Ser Gln His His Gly Pro Cys Glu Pro His 
            260                 265                 270         


Pro Thr Tyr Thr Asp Leu Ser Ser His His Ala Pro Pro Pro Gln Gly 
        275                 280                 285             


Arg Ile Gln Glu Ala Pro Lys Leu Thr His Leu 
    290                 295                 


<210>  5114
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB4__Homo_sapiens__NP_076920

<400>  5114

Met Ala Met Ser Ser Phe Leu Ile Asn Ser Asn Tyr Val Asp Pro Lys 
1               5                   10                  15      


Phe Pro Pro Cys Glu Glu Tyr Ser Gln Ser Asp Tyr Leu Pro Ser Asp 
            20                  25                  30          


His Ser Pro Gly Tyr Tyr Ala Gly Gly Gln Arg Arg Glu Ser Ser Phe 
        35                  40                  45              


Gln Pro Glu Ala Gly Phe Gly Arg Arg Ala Ala Cys Thr Val Gln Arg 
    50                  55                  60                  


Tyr Ala Ala Cys Arg Asp Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Pro Pro Gly Leu Ser Pro Arg Ala Pro Ala Pro 
                85                  90                  95      


Pro Pro Ala Gly Ala Leu Leu Pro Glu Pro Gly Gln Arg Cys Glu Ala 
            100                 105                 110         


Val Ser Ser Ser Pro Pro Pro Pro Pro Cys Ala Gln Asn Pro Leu His 
        115                 120                 125             


Pro Ser Pro Ser His Ser Ala Cys Lys Glu Pro Val Val Tyr Pro Trp 
    130                 135                 140                 


Met Arg Lys Val His Val Ser Thr Val Asn Pro Asn Tyr Ala Gly Gly 
145                 150                 155                 160 


Glu Pro Lys Arg Ser Arg Thr Ala Tyr Thr Arg Gln Gln Val Leu Glu 
                165                 170                 175     


Leu Glu Lys Glu Phe His Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
            180                 185                 190         


Val Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile 
        195                 200                 205             


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp His Lys Leu Pro 
    210                 215                 220                 


Asn Thr Lys Ile Arg Ser Gly Gly Ala Ala Gly Ser Ala Gly Gly Pro 
225                 230                 235                 240 


Pro Gly Arg Pro Asn Gly Gly Pro Arg Ala Leu 
                245                 250     


<210>  5115
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB5__Homo_sapiens__NP_002138

<400>  5115

Met Ser Ser Tyr Phe Val Asn Ser Phe Ser Gly Arg Tyr Pro Asn Gly 
1               5                   10                  15      


Pro Asp Tyr Gln Leu Leu Asn Tyr Gly Ser Gly Ser Ser Leu Ser Gly 
            20                  25                  30          


Ser Tyr Arg Asp Pro Ala Ala Met His Thr Gly Ser Tyr Gly Tyr Asn 
        35                  40                  45              


Tyr Asn Gly Met Asp Leu Ser Val Asn Arg Ser Ser Ala Ser Ser Ser 
    50                  55                  60                  


His Phe Gly Ala Val Gly Glu Ser Ser Arg Ala Phe Pro Ala Pro Ala 
65                  70                  75                  80  


Gln Glu Pro Arg Phe Arg Gln Ala Ala Ser Ser Cys Ser Leu Ser Ser 
                85                  90                  95      


Pro Glu Ser Leu Pro Cys Thr Asn Gly Asp Ser His Gly Ala Lys Pro 
            100                 105                 110         


Ser Ala Ser Ser Pro Ser Asp Gln Ala Thr Ser Ala Ser Ser Ser Ala 
        115                 120                 125             


Asn Phe Thr Glu Ile Asp Glu Ala Ser Ala Ser Ser Glu Pro Glu Glu 
    130                 135                 140                 


Ala Ala Ser Gln Leu Ser Ser Pro Ser Leu Ala Arg Ala Gln Pro Glu 
145                 150                 155                 160 


Pro Met Ala Thr Ser Thr Ala Ala Pro Glu Gly Gln Thr Pro Gln Ile 
                165                 170                 175     


Phe Pro Trp Met Arg Lys Leu His Ile Ser His Asp Met Thr Gly Pro 
            180                 185                 190         


Asp Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu Glu 
        195                 200                 205             


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
    210                 215                 220                 


Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile 
225                 230                 235                 240 


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu Lys 
                245                 250                 255     


Ser Met Ser Leu Ala Thr Ala Gly Ser Ala Phe Gln Pro 
            260                 265                 


<210>  5116
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB6__Homo_sapiens__XP_005257340

<400>  5116

Met Ser Ser Tyr Phe Val Asn Ser Thr Phe Pro Val Thr Leu Ala Ser 
1               5                   10                  15      


Gly Gln Glu Ser Phe Leu Gly Gln Leu Pro Leu Tyr Ser Ser Gly Tyr 
            20                  25                  30          


Ala Asp Pro Leu Arg His Tyr Pro Ala Pro Tyr Gly Pro Gly Pro Gly 
        35                  40                  45              


Gln Asp Lys Gly Phe Ala Thr Ser Ser Tyr Tyr Pro Pro Ala Gly Gly 
    50                  55                  60                  


Gly Tyr Gly Arg Ala Ala Pro Cys Asp Tyr Gly Pro Ala Pro Ala Phe 
65                  70                  75                  80  


Tyr Arg Glu Lys Glu Ser Ala Cys Ala Leu Ser Gly Ala Asp Glu Gln 
                85                  90                  95      


Pro Pro Phe His Pro Glu Pro Arg Lys Ser Asp Cys Ala Gln Asp Lys 
            100                 105                 110         


Ser Val Phe Gly Glu Thr Glu Glu Gln Lys Cys Ser Thr Pro Val Tyr 
        115                 120                 125             


Pro Trp Met Gln Arg Met Asn Ser Cys Asn Ser Ser Ser Phe Gly Pro 
    130                 135                 140                 


Ser Gly Arg Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe His Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
                165                 170                 175     


Ile Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Ser Lys Leu Leu 
        195                 200                 205             


Ser Ala Ser Gln Leu Ser Ala Glu Glu Glu Glu Glu Lys Gln Ala Glu 
    210                 215                 220                 


<210>  5117
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB7__Homo_sapiens__NP_004493

<400>  5117

Met Ser Ser Leu Tyr Tyr Ala Asn Thr Leu Phe Ser Lys Tyr Pro Ala 
1               5                   10                  15      


Ser Ser Ser Val Phe Ala Thr Gly Ala Phe Pro Glu Gln Thr Ser Cys 
            20                  25                  30          


Ala Phe Ala Ser Asn Pro Gln Arg Pro Gly Tyr Gly Ala Gly Ser Gly 
        35                  40                  45              


Ala Ser Phe Ala Ala Ser Met Gln Gly Leu Tyr Pro Gly Gly Gly Gly 
    50                  55                  60                  


Met Ala Gly Gln Ser Ala Ala Gly Val Tyr Ala Ala Gly Tyr Gly Leu 
65                  70                  75                  80  


Glu Pro Ser Ser Phe Asn Met His Cys Ala Pro Phe Glu Gln Asn Leu 
                85                  90                  95      


Ser Gly Val Cys Pro Gly Asp Ser Ala Lys Ala Ala Gly Ala Lys Glu 
            100                 105                 110         


Gln Arg Asp Ser Asp Leu Ala Ala Glu Ser Asn Phe Arg Ile Tyr Pro 
        115                 120                 125             


Trp Met Arg Ser Ser Gly Thr Asp Arg Lys Arg Gly Arg Gln Thr Tyr 
    130                 135                 140                 


Thr Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe His Tyr Asn Arg 
145                 150                 155                 160 


Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Thr Leu Cys Leu 
                165                 170                 175     


Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp 
            180                 185                 190         


Lys Lys Glu Asn Lys Thr Ala Gly Pro Gly Thr Thr Gly Gln Asp Arg 
        195                 200                 205             


Ala Glu Ala Glu Glu Glu Glu Glu Glu 
    210                 215         


<210>  5118
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB8__Homo_sapiens__NP_076921

<400>  5118

Met Ser Ser Tyr Phe Val Asn Ser Leu Phe Ser Lys Tyr Lys Thr Gly 
1               5                   10                  15      


Glu Ser Leu Arg Pro Asn Tyr Tyr Asp Cys Gly Phe Ala Gln Asp Leu 
            20                  25                  30          


Gly Gly Arg Pro Thr Val Val Tyr Gly Pro Ser Ser Gly Gly Ser Phe 
        35                  40                  45              


Gln His Pro Ser Gln Ile Gln Glu Phe Tyr His Gly Pro Ser Ser Leu 
    50                  55                  60                  


Ser Thr Ala Pro Tyr Gln Gln Asn Pro Cys Ala Val Ala Cys His Gly 
65                  70                  75                  80  


Asp Pro Gly Asn Phe Tyr Gly Tyr Asp Pro Leu Gln Arg Gln Ser Leu 
                85                  90                  95      


Phe Gly Ala Gln Asp Pro Asp Leu Val Gln Tyr Ala Asp Cys Lys Leu 
            100                 105                 110         


Ala Ala Ala Ser Gly Leu Gly Glu Glu Ala Glu Gly Ser Glu Gln Ser 
        115                 120                 125             


Pro Ser Pro Thr Gln Leu Phe Pro Trp Met Arg Pro Gln Ala Ala Ala 
    130                 135                 140                 


Gly Arg Arg Arg Gly Arg Gln Thr Tyr Ser Arg Tyr Gln Thr Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Pro Tyr Leu Thr Arg Lys Arg Arg 
                165                 170                 175     


Ile Glu Val Ser His Ala Leu Gly Leu Thr Glu Arg Gln Val Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn Asn Lys Asp 
        195                 200                 205             


Lys Phe Pro Ser Ser Lys Cys Glu Gln Glu Glu Leu Glu Lys Gln Lys 
    210                 215                 220                 


Leu Glu Arg Ala Pro Glu Ala Ala Asp Glu Gly Asp Ala Gln Lys Gly 
225                 230                 235                 240 


Asp Lys Lys 
            


<210>  5119
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXB9__Homo_sapiens__NP_076922

<400>  5119

Met Ser Ile Ser Gly Thr Leu Ser Ser Tyr Tyr Val Asp Ser Ile Ile 
1               5                   10                  15      


Ser His Glu Ser Glu Asp Ala Pro Pro Ala Lys Phe Pro Ser Gly Gln 
            20                  25                  30          


Tyr Ala Ser Ser Arg Gln Pro Gly His Ala Glu His Leu Glu Phe Pro 
        35                  40                  45              


Ser Cys Ser Phe Gln Pro Lys Ala Pro Val Phe Gly Ala Ser Trp Ala 
    50                  55                  60                  


Pro Leu Ser Pro His Ala Ser Gly Ser Leu Pro Ser Val Tyr His Pro 
65                  70                  75                  80  


Tyr Ile Gln Pro Gln Gly Val Pro Pro Ala Glu Ser Arg Tyr Leu Arg 
                85                  90                  95      


Thr Trp Leu Glu Pro Ala Pro Arg Gly Glu Ala Ala Pro Gly Gln Gly 
            100                 105                 110         


Gln Ala Ala Val Lys Ala Glu Pro Leu Leu Gly Ala Pro Gly Glu Leu 
        115                 120                 125             


Leu Lys Gln Gly Thr Pro Glu Tyr Ser Leu Glu Thr Ser Ala Gly Arg 
    130                 135                 140                 


Glu Ala Val Leu Ser Asn Gln Arg Pro Gly Tyr Gly Asp Asn Lys Ile 
145                 150                 155                 160 


Cys Glu Gly Ser Glu Asp Lys Glu Arg Pro Asp Gln Thr Asn Pro Ser 
                165                 170                 175     


Ala Asn Trp Leu His Ala Arg Ser Ser Arg Lys Lys Arg Cys Pro Tyr 
            180                 185                 190         


Thr Lys Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe Leu Phe Asn Met 
        195                 200                 205             


Tyr Leu Thr Arg Asp Arg Arg His Glu Val Ala Arg Leu Leu Asn Leu 
    210                 215                 220                 


Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Met 
225                 230                 235                 240 


Lys Lys Met Asn Lys Glu Gln Gly Lys Glu 
                245                 250 


<210>  5120
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC10__Homo_sapiens__NP_059105

<400>  5120

Met Thr Cys Pro Arg Asn Val Thr Pro Asn Ser Tyr Ala Glu Pro Leu 
1               5                   10                  15      


Ala Ala Pro Gly Gly Gly Glu Arg Tyr Ser Arg Ser Ala Gly Met Tyr 
            20                  25                  30          


Met Gln Ser Gly Ser Asp Phe Asn Cys Gly Val Met Arg Gly Cys Gly 
        35                  40                  45              


Leu Ala Pro Ser Leu Ser Lys Arg Asp Glu Gly Ser Ser Pro Ser Leu 
    50                  55                  60                  


Ala Leu Asn Thr Tyr Pro Ser Tyr Leu Ser Gln Leu Asp Ser Trp Gly 
65                  70                  75                  80  


Asp Pro Lys Ala Ala Tyr Arg Leu Glu Gln Pro Val Gly Arg Pro Leu 
                85                  90                  95      


Ser Ser Cys Ser Tyr Pro Pro Ser Val Lys Glu Glu Asn Val Cys Cys 
            100                 105                 110         


Met Tyr Ser Ala Glu Lys Arg Ala Lys Ser Gly Pro Glu Ala Ala Leu 
        115                 120                 125             


Tyr Ser His Pro Leu Pro Glu Ser Cys Leu Gly Glu His Glu Val Pro 
    130                 135                 140                 


Val Pro Ser Tyr Tyr Arg Ala Ser Pro Ser Tyr Ser Ala Leu Asp Lys 
145                 150                 155                 160 


Thr Pro His Cys Ser Gly Ala Asn Asp Phe Glu Ala Pro Phe Glu Gln 
                165                 170                 175     


Arg Ala Ser Leu Asn Pro Arg Ala Glu His Leu Glu Ser Pro Gln Leu 
            180                 185                 190         


Gly Gly Lys Val Ser Phe Pro Glu Thr Pro Lys Ser Asp Ser Gln Thr 
        195                 200                 205             


Pro Ser Pro Asn Glu Ile Lys Thr Glu Gln Ser Leu Ala Gly Pro Lys 
    210                 215                 220                 


Gly Ser Pro Ser Glu Ser Glu Lys Glu Arg Ala Lys Ala Ala Asp Ser 
225                 230                 235                 240 


Ser Pro Asp Thr Ser Asp Asn Glu Ala Lys Glu Glu Ile Lys Ala Glu 
                245                 250                 255     


Asn Thr Thr Gly Asn Trp Leu Thr Ala Lys Ser Gly Arg Lys Lys Arg 
            260                 265                 270         


Cys Pro Tyr Thr Lys His Gln Thr Leu Glu Leu Glu Lys Glu Phe Leu 
        275                 280                 285             


Phe Asn Met Tyr Leu Thr Arg Glu Arg Arg Leu Glu Ile Ser Lys Thr 
    290                 295                 300                 


Ile Asn Leu Thr Asp Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg 
305                 310                 315                 320 


Met Lys Leu Lys Lys Met Asn Arg Glu Asn Arg Ile Arg Glu Leu Thr 
                325                 330                 335     


Ser Asn Phe Asn Phe Thr 
            340         


<210>  5121
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC11__Homo_sapiens__NP_055027

<400>  5121

Met Phe Asn Ser Val Asn Leu Gly Asn Phe Cys Ser Pro Ser Arg Lys 
1               5                   10                  15      


Glu Arg Gly Ala Asp Phe Gly Glu Arg Gly Ser Cys Ala Ser Asn Leu 
            20                  25                  30          


Tyr Leu Pro Ser Cys Thr Tyr Tyr Met Pro Glu Phe Ser Thr Val Ser 
        35                  40                  45              


Ser Phe Leu Pro Gln Ala Pro Ser Arg Gln Ile Ser Tyr Pro Tyr Ser 
    50                  55                  60                  


Ala Gln Val Pro Pro Val Arg Glu Val Ser Tyr Gly Leu Glu Pro Ser 
65                  70                  75                  80  


Gly Lys Trp His His Arg Asn Ser Tyr Ser Ser Cys Tyr Ala Ala Ala 
                85                  90                  95      


Asp Glu Leu Met His Arg Glu Cys Leu Pro Pro Ser Thr Val Thr Glu 
            100                 105                 110         


Ile Leu Met Lys Asn Glu Gly Ser Tyr Gly Gly His His His Pro Ser 
        115                 120                 125             


Ala Pro His Ala Thr Pro Ala Gly Phe Tyr Ser Ser Val Asn Lys Asn 
    130                 135                 140                 


Ser Val Leu Pro Gln Ala Phe Asp Arg Phe Phe Asp Asn Ala Tyr Cys 
145                 150                 155                 160 


Gly Gly Gly Asp Pro Pro Ala Glu Pro Pro Cys Ser Gly Lys Gly Glu 
                165                 170                 175     


Ala Lys Gly Glu Pro Glu Ala Pro Pro Ala Ser Gly Leu Ala Ser Arg 
            180                 185                 190         


Ala Glu Ala Gly Ala Glu Ala Glu Ala Glu Glu Glu Asn Thr Asn Pro 
        195                 200                 205             


Ser Ser Ser Gly Ser Ala His Ser Val Ala Lys Glu Pro Ala Lys Gly 
    210                 215                 220                 


Ala Ala Pro Asn Ala Pro Arg Thr Arg Lys Lys Arg Cys Pro Tyr Ser 
225                 230                 235                 240 


Lys Phe Gln Ile Arg Glu Leu Glu Arg Glu Phe Phe Phe Asn Val Tyr 
                245                 250                 255     


Ile Asn Lys Glu Lys Arg Leu Gln Leu Ser Arg Met Leu Asn Leu Thr 
            260                 265                 270         


Asp Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Glu Lys 
        275                 280                 285             


Lys Leu Ser Arg Asp Arg Leu Gln Tyr Phe Ser Gly Asn Pro Leu Leu 
    290                 295                 300                 


<210>  5122
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC12__Homo_sapiens__NP_776272

<400>  5122

Met Gly Glu His Asn Leu Leu Asn Pro Gly Phe Val Gly Pro Leu Val 
1               5                   10                  15      


Asn Ile His Thr Gly Asp Thr Phe Tyr Phe Pro Asn Phe Arg Ala Ser 
            20                  25                  30          


Gly Ala Gln Leu Pro Gly Leu Pro Ser Leu Ser Tyr Pro Arg Arg Asp 
        35                  40                  45              


Asn Val Cys Ser Leu Ser Trp Pro Ser Ala Glu Pro Cys Asn Gly Tyr 
    50                  55                  60                  


Pro Gln Pro Tyr Leu Gly Ser Pro Val Ser Leu Asn Pro Pro Phe Gly 
65                  70                  75                  80  


Arg Thr Cys Glu Leu Ala Arg Val Glu Asp Gly Lys Gly Tyr Tyr Arg 
                85                  90                  95      


Glu Pro Cys Ala Glu Gly Gly Gly Gly Gly Leu Lys Arg Glu Glu Arg 
            100                 105                 110         


Gly Arg Asp Pro Gly Ala Gly Pro Gly Ala Ala Leu Leu Pro Leu Glu 
        115                 120                 125             


Pro Ser Gly Pro Pro Ala Leu Gly Phe Lys Tyr Asp Tyr Ala Ala Gly 
    130                 135                 140                 


Gly Gly Gly Gly Asp Gly Gly Gly Gly Ala Gly Pro Pro His Asp Pro 
145                 150                 155                 160 


Pro Ser Cys Gln Ser Leu Glu Ser Asp Ser Ser Ser Ser Leu Leu Asn 
                165                 170                 175     


Glu Gly Asn Lys Gly Ala Gly Ala Gly Asp Pro Gly Ser Leu Val Ser 
            180                 185                 190         


Pro Leu Asn Pro Gly Gly Gly Leu Ser Ala Ser Gly Ala Pro Trp Tyr 
        195                 200                 205             


Pro Ile Asn Ser Arg Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu 
    210                 215                 220                 


Gln Leu Ala Glu Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr 
225                 230                 235                 240 


Arg Gln Arg Arg Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln 
                245                 250                 255     


Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu 
            260                 265                 270         


Leu Leu Arg Glu Gln Ala Leu Ser Phe Phe 
        275                 280         


<210>  5123
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC13__Homo_sapiens__NP_059106

<400>  5123

Met Thr Thr Ser Leu Leu Leu His Pro Arg Trp Pro Glu Ser Leu Met 
1               5                   10                  15      


Tyr Val Tyr Glu Asp Ser Ala Ala Glu Ser Gly Ile Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Thr Gly Gly Ala Gly Gly Gly Cys Ser Gly 
        35                  40                  45              


Ala Ser Pro Gly Lys Ala Pro Ser Met Asp Gly Leu Gly Ser Ser Cys 
    50                  55                  60                  


Pro Ala Ser His Cys Arg Asp Leu Leu Pro His Pro Val Leu Gly Arg 
65                  70                  75                  80  


Pro Pro Ala Pro Leu Gly Ala Pro Gln Gly Ala Val Tyr Thr Asp Ile 
                85                  90                  95      


Pro Ala Pro Glu Ala Ala Arg Gln Cys Ala Pro Pro Pro Ala Pro Pro 
            100                 105                 110         


Thr Ser Ser Ser Ala Thr Leu Gly Tyr Gly Tyr Pro Phe Gly Gly Ser 
        115                 120                 125             


Tyr Tyr Gly Cys Arg Leu Ser His Asn Val Asn Leu Gln Gln Lys Pro 
    130                 135                 140                 


Cys Ala Tyr His Pro Gly Asp Lys Tyr Pro Glu Pro Ser Gly Ala Leu 
145                 150                 155                 160 


Pro Gly Asp Asp Leu Ser Ser Arg Ala Lys Glu Phe Ala Phe Tyr Pro 
                165                 170                 175     


Ser Phe Ala Ser Ser Tyr Gln Ala Met Pro Gly Tyr Leu Asp Val Ser 
            180                 185                 190         


Val Val Pro Gly Ile Ser Gly His Pro Glu Pro Arg His Asp Ala Leu 
        195                 200                 205             


Ile Pro Val Glu Gly Tyr Gln His Trp Ala Leu Ser Asn Gly Trp Asp 
    210                 215                 220                 


Ser Gln Val Tyr Cys Ser Lys Glu Gln Ser Gln Ser Ala His Leu Trp 
225                 230                 235                 240 


Lys Ser Pro Phe Pro Asp Val Val Pro Leu Gln Pro Glu Val Ser Ser 
                245                 250                 255     


Tyr Arg Arg Gly Arg Lys Lys Arg Val Pro Tyr Thr Lys Val Gln Leu 
            260                 265                 270         


Lys Glu Leu Glu Lys Glu Tyr Ala Ala Ser Lys Phe Ile Thr Lys Glu 
        275                 280                 285             


Lys Arg Arg Arg Ile Ser Ala Thr Thr Asn Leu Ser Glu Arg Gln Val 
    290                 295                 300                 


Thr Ile Trp Phe Gln Asn Arg Arg Val Lys Glu Lys Lys Val Val Ser 
305                 310                 315                 320 


Lys Ser Lys Ala Pro His Leu His Ser Thr 
                325                 330 


<210>  5124
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC4__Homo_sapiens__NP_705897

<400>  5124

Met Ile Met Ser Ser Tyr Leu Met Asp Ser Asn Tyr Ile Asp Pro Lys 
1               5                   10                  15      


Phe Pro Pro Cys Glu Glu Tyr Ser Gln Asn Ser Tyr Ile Pro Glu His 
            20                  25                  30          


Ser Pro Glu Tyr Tyr Gly Arg Thr Arg Glu Ser Gly Phe Gln His His 
        35                  40                  45              


His Gln Glu Leu Tyr Pro Pro Pro Pro Pro Arg Pro Ser Tyr Pro Glu 
    50                  55                  60                  


Arg Gln Tyr Ser Cys Thr Ser Leu Gln Gly Pro Gly Asn Ser Arg Gly 
65                  70                  75                  80  


His Gly Pro Ala Gln Ala Gly His His His Pro Glu Lys Ser Gln Ser 
                85                  90                  95      


Leu Cys Glu Pro Ala Pro Leu Ser Gly Ala Ser Ala Ser Pro Ser Pro 
            100                 105                 110         


Ala Pro Pro Ala Cys Ser Gln Pro Ala Pro Asp His Pro Ser Ser Ala 
        115                 120                 125             


Ala Ser Lys Gln Pro Ile Val Tyr Pro Trp Met Lys Lys Ile His Val 
    130                 135                 140                 


Ser Thr Val Asn Pro Asn Tyr Asn Gly Gly Glu Pro Lys Arg Ser Arg 
145                 150                 155                 160 


Thr Ala Tyr Thr Arg Gln Gln Val Leu Glu Leu Glu Lys Glu Phe His 
                165                 170                 175     


Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Ser 
            180                 185                 190         


Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg 
        195                 200                 205             


Met Lys Trp Lys Lys Asp His Arg Leu Pro Asn Thr Lys Val Arg Ser 
    210                 215                 220                 


Ala Pro Pro Ala Gly Ala Ala Pro Ser Thr Leu Ser Ala Ala Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Glu Asp His Ser Gln Ser Ala Thr Pro Pro Glu Gln Gln 
                245                 250                 255     


Arg Ala Glu Asp Ile Thr Arg Leu 
            260                 


<210>  5125
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC5__Homo_sapiens__NP_061826

<400>  5125

Met Ser Ser Tyr Val Ala Asn Ser Phe Tyr Lys Gln Ser Pro Asn Ile 
1               5                   10                  15      


Pro Ala Tyr Asn Met Gln Thr Cys Gly Asn Tyr Gly Ser Ala Ser Glu 
            20                  25                  30          


Val Gln Ala Ser Arg Tyr Cys Tyr Gly Gly Leu Asp Leu Ser Ile Thr 
        35                  40                  45              


Phe Pro Pro Pro Ala Pro Ser Asn Ser Leu His Gly Val Asp Met Ala 
    50                  55                  60                  


Ala Asn Pro Arg Ala His Pro Asp Arg Pro Ala Cys Ser Ala Ala Ala 
65                  70                  75                  80  


Ala Pro Gly His Ala Pro Gly Arg Asp Glu Ala Ala Pro Leu Asn Pro 
                85                  90                  95      


Gly Met Tyr Ser Gln Lys Ala Ala Arg Pro Ala Leu Glu Glu Arg Ala 
            100                 105                 110         


Lys Ser Ser Gly Glu Ile Lys Glu Glu Gln Ala Gln Thr Gly Gln Pro 
        115                 120                 125             


Ala Gly Leu Ser Gln Pro Pro Ala Pro Pro Gln Ile Tyr Pro Trp Met 
    130                 135                 140                 


Thr Lys Leu His Met Ser His Glu Thr Asp Gly Lys Arg Ser Arg Thr 
145                 150                 155                 160 


Ser Tyr Thr Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe His Phe 
                165                 170                 175     


Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala Asn Asn Leu 
            180                 185                 190         


Cys Leu Asn Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met 
        195                 200                 205             


Lys Trp Lys Lys Asp Ser Lys Met Lys Ser Lys Glu Ala Leu 
    210                 215                 220         


<210>  5126
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC6__Homo_sapiens__NP_004494

<400>  5126

Met Asn Ser Tyr Phe Thr Asn Pro Ser Leu Ser Cys His Leu Ala Gly 
1               5                   10                  15      


Gly Gln Asp Val Leu Pro Asn Val Ala Leu Asn Ser Thr Ala Tyr Asp 
            20                  25                  30          


Pro Val Arg His Phe Ser Thr Tyr Gly Ala Ala Val Ala Gln Asn Arg 
        35                  40                  45              


Ile Tyr Ser Thr Pro Phe Tyr Ser Pro Gln Glu Asn Val Val Phe Ser 
    50                  55                  60                  


Ser Ser Arg Gly Pro Tyr Asp Tyr Gly Ser Asn Ser Phe Tyr Gln Glu 
65                  70                  75                  80  


Lys Asp Met Leu Ser Asn Cys Arg Gln Asn Thr Leu Gly His Asn Thr 
                85                  90                  95      


Gln Thr Ser Ile Ala Gln Asp Phe Ser Ser Glu Gln Gly Arg Thr Ala 
            100                 105                 110         


Pro Gln Asp Gln Lys Ala Ser Ile Gln Ile Tyr Pro Trp Met Gln Arg 
        115                 120                 125             


Met Asn Ser His Ser Gly Val Gly Tyr Gly Ala Asp Arg Arg Arg Gly 
    130                 135                 140                 


Arg Gln Ile Tyr Ser Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe 
145                 150                 155                 160 


His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala Asn 
                165                 170                 175     


Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg 
            180                 185                 190         


Arg Met Lys Trp Lys Lys Glu Ser Asn Leu Thr Ser Thr Leu Ser Gly 
        195                 200                 205             


Gly Gly Gly Gly Ala Thr Ala Asp Ser Leu Gly Gly Lys Glu Glu Lys 
    210                 215                 220                 


Arg Glu Glu Thr Glu Glu Glu Lys Gln Lys Glu 
225                 230                 235 


<210>  5127
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC8__Homo_sapiens__NP_073149

<400>  5127

Met Ser Ser Tyr Phe Val Asn Pro Leu Phe Ser Lys Tyr Lys Ala Gly 
1               5                   10                  15      


Glu Ser Leu Glu Pro Ala Tyr Tyr Asp Cys Arg Phe Pro Gln Ser Val 
            20                  25                  30          


Gly Arg Ser His Ala Leu Val Tyr Gly Pro Gly Gly Ser Ala Pro Gly 
        35                  40                  45              


Phe Gln His Ala Ser His His Val Gln Asp Phe Phe His His Gly Thr 
    50                  55                  60                  


Ser Gly Ile Ser Asn Ser Gly Tyr Gln Gln Asn Pro Cys Ser Leu Ser 
65                  70                  75                  80  


Cys His Gly Asp Ala Ser Lys Phe Tyr Gly Tyr Glu Ala Leu Pro Arg 
                85                  90                  95      


Gln Ser Leu Tyr Gly Ala Gln Gln Glu Ala Ser Val Val Gln Tyr Pro 
            100                 105                 110         


Asp Cys Lys Ser Ser Ala Asn Thr Asn Ser Ser Glu Gly Gln Gly His 
        115                 120                 125             


Leu Asn Gln Asn Ser Ser Pro Ser Leu Met Phe Pro Trp Met Arg Pro 
    130                 135                 140                 


His Ala Pro Gly Arg Arg Ser Gly Arg Gln Thr Tyr Ser Arg Tyr Gln 
145                 150                 155                 160 


Thr Leu Glu Leu Glu Lys Glu Phe Leu Phe Asn Pro Tyr Leu Thr Arg 
                165                 170                 175     


Lys Arg Arg Ile Glu Val Ser His Ala Leu Gly Leu Thr Glu Arg Gln 
            180                 185                 190         


Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
        195                 200                 205             


Asn Lys Asp Lys Leu Pro Gly Ala Arg Asp Glu Glu Lys Val Glu Glu 
    210                 215                 220                 


Glu Gly Asn Glu Glu Glu Glu Lys Glu Glu Glu Glu Lys Glu Glu Asn 
225                 230                 235                 240 


Lys Asp 
        


<210>  5128
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXC9__Homo_sapiens__NP_008828

<400>  5128

Met Ser Ala Thr Gly Pro Ile Ser Asn Tyr Tyr Val Asp Ser Leu Ile 
1               5                   10                  15      


Ser His Asp Asn Glu Asp Leu Leu Ala Ser Arg Phe Pro Ala Thr Gly 
            20                  25                  30          


Ala His Pro Ala Ala Ala Arg Pro Ser Gly Leu Val Pro Asp Cys Ser 
        35                  40                  45              


Asp Phe Pro Ser Cys Ser Phe Ala Pro Lys Pro Ala Val Phe Ser Thr 
    50                  55                  60                  


Ser Trp Ala Pro Val Pro Ser Gln Ser Ser Val Val Tyr His Pro Tyr 
65                  70                  75                  80  


Gly Pro Gln Pro His Leu Gly Ala Asp Thr Arg Tyr Met Arg Thr Trp 
                85                  90                  95      


Leu Glu Pro Leu Ser Gly Ala Val Ser Phe Pro Ser Phe Pro Ala Gly 
            100                 105                 110         


Gly Arg His Tyr Ala Leu Lys Pro Asp Ala Tyr Pro Gly Arg Arg Ala 
        115                 120                 125             


Asp Cys Gly Pro Gly Glu Gly Arg Ser Tyr Pro Asp Tyr Met Tyr Gly 
    130                 135                 140                 


Ser Pro Gly Glu Leu Arg Asp Arg Ala Pro Gln Thr Leu Pro Ser Pro 
145                 150                 155                 160 


Glu Ala Asp Ala Leu Ala Gly Ser Lys His Lys Glu Glu Lys Ala Asp 
                165                 170                 175     


Leu Asp Pro Ser Asn Pro Val Ala Asn Trp Ile His Ala Arg Ser Thr 
            180                 185                 190         


Arg Lys Lys Arg Cys Pro Tyr Thr Lys Tyr Gln Thr Leu Glu Leu Glu 
        195                 200                 205             


Lys Glu Phe Leu Phe Asn Met Tyr Leu Thr Arg Asp Arg Arg Tyr Glu 
    210                 215                 220                 


Val Ala Arg Val Leu Asn Leu Thr Glu Arg Gln Val Lys Ile Trp Phe 
225                 230                 235                 240 


Gln Asn Arg Arg Met Lys Met Lys Lys Met Asn Lys Glu Lys Thr Asp 
                245                 250                 255     


Lys Glu Gln Ser 
            260 


<210>  5129
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD10__Homo_sapiens__NP_002139

<400>  5129

Met Ser Phe Pro Asn Ser Ser Pro Ala Ala Asn Thr Phe Leu Val Asp 
1               5                   10                  15      


Ser Leu Ile Ser Ala Cys Arg Ser Asp Ser Phe Tyr Ser Ser Ser Ala 
            20                  25                  30          


Ser Met Tyr Met Pro Pro Pro Ser Ala Asp Met Gly Thr Tyr Gly Met 
        35                  40                  45              


Gln Thr Cys Gly Leu Leu Pro Ser Leu Ala Lys Arg Glu Val Asn His 
    50                  55                  60                  


Gln Asn Met Gly Met Asn Val His Pro Tyr Ile Pro Gln Val Asp Ser 
65                  70                  75                  80  


Trp Thr Asp Pro Asn Arg Ser Cys Arg Ile Glu Gln Pro Val Thr Gln 
                85                  90                  95      


Gln Val Pro Thr Cys Ser Phe Thr Thr Asn Ile Lys Glu Glu Ser Asn 
            100                 105                 110         


Cys Cys Met Tyr Ser Asp Lys Arg Asn Lys Leu Ile Ser Ala Glu Val 
        115                 120                 125             


Pro Ser Tyr Gln Arg Leu Val Pro Glu Ser Cys Pro Val Glu Asn Pro 
    130                 135                 140                 


Glu Val Pro Val Pro Gly Tyr Phe Arg Leu Ser Gln Thr Tyr Ala Thr 
145                 150                 155                 160 


Gly Lys Thr Gln Glu Tyr Asn Asn Ser Pro Glu Gly Ser Ser Thr Val 
                165                 170                 175     


Met Leu Gln Leu Asn Pro Arg Gly Ala Ala Lys Pro Gln Leu Ser Ala 
            180                 185                 190         


Ala Gln Leu Gln Met Glu Lys Lys Met Asn Glu Pro Val Ser Gly Gln 
        195                 200                 205             


Glu Pro Thr Lys Val Ser Gln Val Glu Ser Pro Glu Ala Lys Gly Gly 
    210                 215                 220                 


Leu Pro Glu Glu Arg Ser Cys Leu Ala Glu Val Ser Val Ser Ser Pro 
225                 230                 235                 240 


Glu Val Gln Glu Lys Glu Ser Lys Glu Glu Ile Lys Ser Asp Thr Pro 
                245                 250                 255     


Thr Ser Asn Trp Leu Thr Ala Lys Ser Gly Arg Lys Lys Arg Cys Pro 
            260                 265                 270         


Tyr Thr Lys His Gln Thr Leu Glu Leu Glu Lys Glu Phe Leu Phe Asn 
        275                 280                 285             


Met Tyr Leu Thr Arg Glu Arg Arg Leu Glu Ile Ser Lys Ser Val Asn 
    290                 295                 300                 


Leu Thr Asp Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys 
305                 310                 315                 320 


Leu Lys Lys Met Ser Arg Glu Asn Arg Ile Arg Glu Leu Thr Ala Asn 
                325                 330                 335     


Leu Thr Phe Ser 
            340 


<210>  5130
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD11__Homo_sapiens__NP_067015

<400>  5130

Met Asn Asp Phe Asp Glu Cys Gly Gln Ser Ala Ala Ser Met Tyr Leu 
1               5                   10                  15      


Pro Gly Cys Ala Tyr Tyr Val Ala Pro Ser Asp Phe Ala Ser Lys Pro 
            20                  25                  30          


Ser Phe Leu Ser Gln Pro Ser Ser Cys Gln Met Thr Phe Pro Tyr Ser 
        35                  40                  45              


Ser Asn Leu Ala Pro His Val Gln Pro Val Arg Glu Val Ala Phe Arg 
    50                  55                  60                  


Asp Tyr Gly Leu Glu Arg Ala Lys Trp Pro Tyr Arg Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Ala Gly Gly Gly Ser Ser Gly Gly Gly Pro Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Ala Gly Gly Tyr Ala Pro Tyr Tyr Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ala Ala Glu Glu Ala Ala Met Gln Arg Glu 
        115                 120                 125             


Leu Leu Pro Pro Ala Gly Arg Arg Pro Asp Val Leu Phe Lys Ala Pro 
    130                 135                 140                 


Glu Pro Val Cys Ala Ala Pro Gly Pro Pro His Gly Pro Ala Gly Ala 
145                 150                 155                 160 


Ala Ser Asn Phe Tyr Ser Ala Val Gly Arg Asn Gly Ile Leu Pro Gln 
                165                 170                 175     


Gly Phe Asp Gln Phe Tyr Glu Ala Ala Pro Gly Pro Pro Phe Ala Gly 
            180                 185                 190         


Pro Gln Pro Pro Pro Pro Pro Ala Pro Pro Gln Pro Glu Gly Ala Ala 
        195                 200                 205             


Asp Lys Gly Asp Pro Arg Thr Gly Ala Gly Gly Gly Gly Gly Ser Pro 
    210                 215                 220                 


Cys Thr Lys Ala Thr Pro Gly Ser Glu Pro Lys Gly Ala Ala Glu Gly 
225                 230                 235                 240 


Ser Gly Gly Asp Gly Glu Gly Pro Pro Gly Glu Ala Gly Ala Glu Lys 
                245                 250                 255     


Ser Ser Ser Ala Val Ala Pro Gln Arg Ser Arg Lys Lys Arg Cys Pro 
            260                 265                 270         


Tyr Thr Lys Tyr Gln Ile Arg Glu Leu Glu Arg Glu Phe Phe Phe Asn 
        275                 280                 285             


Val Tyr Ile Asn Lys Glu Lys Arg Leu Gln Leu Ser Arg Met Leu Asn 
    290                 295                 300                 


Leu Thr Asp Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys 
305                 310                 315                 320 


Glu Lys Lys Leu Asn Arg Asp Arg Leu Gln Tyr Phe Thr Gly Asn Pro 
                325                 330                 335     


Leu Phe 
        


<210>  5131
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD12__Homo_sapiens__NP_067016

<400>  5131

Met Cys Glu Arg Ser Leu Tyr Arg Ala Gly Tyr Val Gly Ser Leu Leu 
1               5                   10                  15      


Asn Leu Gln Ser Pro Asp Ser Phe Tyr Phe Ser Asn Leu Arg Pro Asn 
            20                  25                  30          


Gly Gly Gln Leu Ala Ala Leu Pro Pro Ile Ser Tyr Pro Arg Gly Ala 
        35                  40                  45              


Leu Pro Trp Ala Ala Thr Pro Ala Ser Cys Ala Pro Ala Gln Pro Ala 
    50                  55                  60                  


Gly Ala Thr Ala Phe Gly Gly Phe Ser Gln Pro Tyr Leu Ala Gly Ser 
65                  70                  75                  80  


Gly Pro Leu Gly Leu Gln Pro Pro Thr Ala Lys Asp Gly Pro Glu Glu 
                85                  90                  95      


Gln Ala Lys Phe Tyr Ala Pro Glu Ala Ala Ala Gly Pro Glu Glu Arg 
            100                 105                 110         


Gly Arg Thr Arg Pro Ser Phe Ala Pro Glu Ser Ser Leu Ala Pro Ala 
        115                 120                 125             


Val Ala Ala Leu Lys Ala Ala Lys Tyr Asp Tyr Ala Gly Val Gly Arg 
    130                 135                 140                 


Ala Thr Pro Gly Ser Thr Thr Leu Leu Gln Gly Ala Pro Cys Ala Pro 
145                 150                 155                 160 


Gly Phe Lys Asp Asp Thr Lys Gly Pro Leu Asn Leu Asn Met Thr Val 
                165                 170                 175     


Gln Ala Ala Gly Val Ala Ser Cys Leu Arg Pro Ser Leu Pro Asp Gly 
            180                 185                 190         


Leu Pro Trp Gly Ala Ala Pro Gly Arg Ala Arg Lys Lys Arg Lys Pro 
        195                 200                 205             


Tyr Thr Lys Gln Gln Ile Ala Glu Leu Glu Asn Glu Phe Leu Val Asn 
    210                 215                 220                 


Glu Phe Ile Asn Arg Gln Lys Arg Lys Glu Leu Ser Asn Arg Leu Asn 
225                 230                 235                 240 


Leu Ser Asp Gln Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys 
                245                 250                 255     


Lys Lys Arg Val Val Leu Arg Glu Gln Ala Leu Ala Leu Tyr 
            260                 265                 270 


<210>  5132
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD13__Homo_sapiens__NP_000514

<400>  5132

Met Ser Arg Ala Gly Ser Trp Asp Met Asp Gly Leu Arg Ala Asp Gly 
1               5                   10                  15      


Gly Gly Ala Gly Gly Ala Pro Ala Ser Ser Ser Ser Ser Ser Val Ala 
            20                  25                  30          


Ala Ala Ala Ala Ser Gly Gln Cys Arg Gly Phe Leu Ser Ala Pro Val 
        35                  40                  45              


Phe Ala Gly Thr His Ser Gly Arg Ala Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ser Gly Phe Ala Tyr Pro Gly Thr Ser 
65                  70                  75                  80  


Glu Arg Thr Gly Ser Ser Ser Ser Ser Ser Ser Ser Ala Val Val Ala 
                85                  90                  95      


Ala Arg Pro Glu Ala Pro Pro Ala Lys Glu Cys Pro Ala Pro Thr Pro 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Pro Pro Ser Ala Pro Ala Leu Gly Tyr Gly 
        115                 120                 125             


Tyr His Phe Gly Asn Gly Tyr Tyr Ser Cys Arg Met Ser His Gly Val 
    130                 135                 140                 


Gly Leu Gln Gln Asn Ala Leu Lys Ser Ser Pro His Ala Ser Leu Gly 
145                 150                 155                 160 


Gly Phe Pro Val Glu Lys Tyr Met Asp Val Ser Gly Leu Ala Ser Ser 
                165                 170                 175     


Ser Val Pro Ala Asn Glu Val Pro Ala Arg Ala Lys Glu Val Ser Phe 
            180                 185                 190         


Tyr Gln Gly Tyr Thr Ser Pro Tyr Gln His Val Pro Gly Tyr Ile Asp 
        195                 200                 205             


Met Val Ser Thr Phe Gly Ser Gly Glu Pro Arg His Glu Ala Tyr Ile 
    210                 215                 220                 


Ser Met Glu Gly Tyr Gln Ser Trp Thr Leu Ala Asn Gly Trp Asn Ser 
225                 230                 235                 240 


Gln Val Tyr Cys Thr Lys Asp Gln Pro Gln Gly Ser His Phe Trp Lys 
                245                 250                 255     


Ser Ser Phe Pro Gly Asp Val Ala Leu Asn Gln Pro Asp Met Cys Val 
            260                 265                 270         


Tyr Arg Arg Gly Arg Lys Lys Arg Val Pro Tyr Thr Lys Leu Gln Leu 
        275                 280                 285             


Lys Glu Leu Glu Asn Glu Tyr Ala Ile Asn Lys Phe Ile Asn Lys Asp 
    290                 295                 300                 


Lys Arg Arg Arg Ile Ser Ala Ala Thr Asn Leu Ser Glu Arg Gln Val 
305                 310                 315                 320 


Thr Ile Trp Phe Gln Asn Arg Arg Val Lys Asp Lys Lys Ile Val Ser 
                325                 330                 335     


Lys Leu Lys Asp Thr Val Ser 
            340             


<210>  5133
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD1__Homo_sapiens__NP_078777

<400>  5133

Met Ser Ser Tyr Leu Glu Tyr Val Ser Cys Ser Ser Ser Gly Gly Val 
1               5                   10                  15      


Gly Gly Asp Val Leu Ser Leu Ala Pro Lys Phe Cys Arg Ser Asp Ala 
            20                  25                  30          


Arg Pro Val Ala Leu Gln Pro Ala Phe Pro Leu Gly Asn Gly Asp Gly 
        35                  40                  45              


Ala Phe Val Ser Cys Leu Pro Leu Ala Ala Ala Arg Pro Ser Pro Ser 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ala Arg Pro Ser Val Pro Pro Pro Ala Ala Pro 
65                  70                  75                  80  


Gln Tyr Ala Gln Cys Thr Leu Glu Gly Ala Tyr Glu Pro Gly Ala Ala 
                85                  90                  95      


Pro Ala Ala Ala Ala Gly Gly Ala Asp Tyr Gly Phe Leu Gly Ser Gly 
            100                 105                 110         


Pro Ala Tyr Asp Phe Pro Gly Val Leu Gly Arg Ala Ala Asp Asp Gly 
        115                 120                 125             


Gly Ser His Val His Tyr Ala Thr Ser Ala Val Phe Ser Gly Gly Gly 
    130                 135                 140                 


Ser Phe Leu Leu Ser Gly Gln Val Asp Tyr Ala Ala Phe Gly Glu Pro 
145                 150                 155                 160 


Gly Pro Phe Pro Ala Cys Leu Lys Ala Ser Ala Asp Gly His Pro Gly 
                165                 170                 175     


Ala Phe Gln Thr Ala Ser Pro Ala Pro Gly Thr Tyr Pro Lys Ser Val 
            180                 185                 190         


Ser Pro Ala Ser Gly Leu Pro Ala Ala Phe Ser Thr Phe Glu Trp Met 
        195                 200                 205             


Lys Val Lys Arg Asn Ala Ser Lys Lys Gly Lys Leu Ala Glu Tyr Gly 
    210                 215                 220                 


Ala Ala Ser Pro Ser Ser Ala Ile Arg Thr Asn Phe Ser Thr Lys Gln 
225                 230                 235                 240 


Leu Thr Glu Leu Glu Lys Glu Phe His Phe Asn Lys Tyr Leu Thr Arg 
                245                 250                 255     


Ala Arg Arg Ile Glu Ile Ala Asn Cys Leu His Leu Asn Asp Thr Gln 
            260                 265                 270         


Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Gln Lys Lys Arg Glu 
        275                 280                 285             


Arg Glu Gly Leu Leu Ala Thr Ala Ile Pro Val Ala Pro Leu Gln Leu 
    290                 295                 300                 


Pro Leu Ser Gly Thr Thr Pro Thr Lys Phe Ile Lys Asn Pro Gly Ser 
305                 310                 315                 320 


Pro Ser Gln Ser Gln Glu Pro Ser 
                325             


<210>  5134
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD3__Homo_sapiens__XP_006712540

<400>  5134

Met Leu Phe Glu Gln Gly Gln Gln Ala Leu Glu Leu Pro Glu Cys Thr 
1               5                   10                  15      


Met Gln Lys Ala Ala Tyr Tyr Glu Asn Pro Gly Leu Phe Gly Gly Tyr 
            20                  25                  30          


Gly Tyr Ser Lys Thr Thr Asp Thr Tyr Gly Tyr Ser Thr Pro His Gln 
        35                  40                  45              


Pro Tyr Pro Pro Pro Ala Ala Ala Ser Ser Leu Asp Thr Asp Tyr Pro 
    50                  55                  60                  


Gly Ser Ala Cys Ser Ile Gln Ser Ser Ala Pro Leu Arg Ala Pro Ala 
65                  70                  75                  80  


His Lys Gly Ala Glu Leu Asn Gly Ser Cys Met Arg Pro Gly Thr Gly 
                85                  90                  95      


Asn Ser Gln Gly Gly Gly Gly Gly Ser Gln Pro Pro Gly Leu Asn Ser 
            100                 105                 110         


Glu Gln Gln Pro Pro Gln Pro Pro Pro Pro Pro Pro Thr Leu Pro Pro 
        115                 120                 125             


Ser Ser Pro Thr Asn Pro Gly Gly Gly Val Pro Ala Lys Lys Pro Lys 
    130                 135                 140                 


Gly Gly Pro Asn Ala Ser Ser Ser Ser Ala Thr Ile Ser Lys Gln Ile 
145                 150                 155                 160 


Phe Pro Trp Met Lys Glu Ser Arg Gln Asn Ser Lys Gln Lys Asn Ser 
                165                 170                 175     


Cys Ala Thr Ala Gly Glu Ser Cys Glu Asp Lys Ser Pro Pro Gly Pro 
            180                 185                 190         


Ala Ser Lys Arg Val Arg Thr Ala Tyr Thr Ser Ala Gln Leu Val Glu 
        195                 200                 205             


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Cys Arg Pro Arg Arg 
    210                 215                 220                 


Val Glu Met Ala Asn Leu Leu Asn Leu Thr Glu Arg Gln Ile Lys Ile 
225                 230                 235                 240 


Trp Phe Gln Asn Arg Arg Met Lys Tyr Lys Lys Asp Gln Lys Ala Lys 
                245                 250                 255     


Gly Ile Leu His Ser Pro Ala Ser Gln Ser Pro Glu Arg Ser Pro Pro 
            260                 265                 270         


Leu Gly Gly Ala Ala Gly His Val Ala Tyr Ser Gly Gln Leu Pro Pro 
        275                 280                 285             


Val Pro Gly Leu Ala Tyr Asp Ala Pro Ser Pro Pro Ala Phe Ala Lys 
    290                 295                 300                 


Ser Gln Pro Asn Met Tyr Gly Leu Ala Ala Tyr Thr Ala Pro Leu Ser 
305                 310                 315                 320 


Ser Cys Leu Pro Gln Gln Lys Arg Tyr Ala Ala Pro Glu Phe Glu Pro 
                325                 330                 335     


His Pro Met Ala Ser Asn Gly Gly Gly Phe Ala Ser Ala Asn Leu Gln 
            340                 345                 350         


Gly Ser Pro Val Tyr Val Gly Gly Asn Phe Val Glu Ser Met Ala Pro 
        355                 360                 365             


Ala Ser Gly Pro Val Phe Asn Leu Gly His Leu Ser His Pro Ser Ser 
    370                 375                 380                 


Ala Ser Val Asp Tyr Ser Cys Ala Ala Gln Ile Pro Gly Asn His His 
385                 390                 395                 400 


His Gly Pro Cys Asp Pro His Pro Thr Tyr Thr Asp Leu Ser Ala His 
                405                 410                 415     


His Ser Ser Gln Gly Arg Leu Pro Glu Ala Pro Lys Leu Thr His Leu 
            420                 425                 430         


<210>  5135
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD4__Homo_sapiens__NP_055436

<400>  5135

Met Val Met Ser Ser Tyr Met Val Asn Ser Lys Tyr Val Asp Pro Lys 
1               5                   10                  15      


Phe Pro Pro Cys Glu Glu Tyr Leu Gln Gly Gly Tyr Leu Gly Glu Gln 
            20                  25                  30          


Gly Ala Asp Tyr Tyr Gly Gly Gly Ala Gln Gly Ala Asp Phe Gln Pro 
        35                  40                  45              


Pro Gly Leu Tyr Pro Arg Pro Asp Phe Gly Glu Gln Pro Phe Gly Gly 
    50                  55                  60                  


Ser Gly Pro Gly Pro Gly Ser Ala Leu Pro Ala Arg Gly His Gly Gln 
65                  70                  75                  80  


Glu Pro Gly Gly Pro Gly Gly His Tyr Ala Ala Pro Gly Glu Pro Cys 
                85                  90                  95      


Pro Ala Pro Pro Ala Pro Pro Pro Ala Pro Leu Pro Gly Ala Arg Ala 
            100                 105                 110         


Tyr Ser Gln Ser Asp Pro Lys Gln Pro Pro Ser Gly Thr Ala Leu Lys 
        115                 120                 125             


Gln Pro Ala Val Val Tyr Pro Trp Met Lys Lys Val His Val Asn Ser 
    130                 135                 140                 


Val Asn Pro Asn Tyr Thr Gly Gly Glu Pro Lys Arg Ser Arg Thr Ala 
145                 150                 155                 160 


Tyr Thr Arg Gln Gln Val Leu Glu Leu Glu Lys Glu Phe His Phe Asn 
                165                 170                 175     


Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Thr Leu Cys 
            180                 185                 190         


Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys 
        195                 200                 205             


Trp Lys Lys Asp His Lys Leu Pro Asn Thr Lys Gly Arg Ser Ser Ser 
    210                 215                 220                 


Ser Ser Ser Ser Ser Ser Cys Ser Ser Ser Val Ala Pro Ser Gln His 
225                 230                 235                 240 


Leu Gln Pro Met Ala Lys Asp His His Thr Asp Leu Thr Thr Leu 
                245                 250                 255 


<210>  5136
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD8__Homo_sapiens__NP_001186675

<400>  5136

Met Ser Ser Tyr Phe Val Asn Pro Leu Tyr Ser Lys Tyr Lys Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Ala Gly Glu Ala Ile Asn Pro Thr Tyr Tyr 
            20                  25                  30          


Asp Cys His Phe Ala Pro Glu Val Gly Gly Arg His Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Leu Gln Leu Tyr Gly Asn Ser Ala Ala Gly Phe Pro His Ala 
    50                  55                  60                  


Pro Pro Gln Ala His Ala His Pro His Pro Ser Pro Pro Pro Ser Gly 
65                  70                  75                  80  


Thr Gly Cys Gly Gly Arg Glu Gly Arg Gly Gln Glu Tyr Phe His Pro 
                85                  90                  95      


Gly Gly Gly Ser Pro Ala Ala Ala Tyr Gln Ala Ala Pro Pro Pro Pro 
            100                 105                 110         


Pro His Pro Pro Pro Pro Pro Pro Pro Pro Pro Cys Gly Gly Ile Ala 
        115                 120                 125             


Cys His Gly Glu Pro Ala Lys Phe Tyr Gly Tyr Asp Asn Leu Gln Arg 
    130                 135                 140                 


Gln Pro Ile Phe Thr Thr Gln Gln Glu Ala Glu Leu Val Gln Tyr Pro 
145                 150                 155                 160 


Asp Cys Lys Ser Ser Ser Gly Asn Ile Gly Glu Asp Pro Asp His Leu 
                165                 170                 175     


Asn Gln Ser Ser Ser Pro Ser Gln Met Phe Pro Trp Met Arg Pro Gln 
            180                 185                 190         


Ala Pro Gly Arg Arg Arg Gly Arg Gln Thr Tyr Ser Arg Phe Gln Thr 
        195                 200                 205             


Leu Glu Leu Glu Lys Glu Phe Leu Phe Asn Pro Tyr Leu Thr Arg Lys 
    210                 215                 220                 


Arg Arg Ile Glu Val Ser His Ala Leu Ala Leu Thr Glu Arg Gln Val 
225                 230                 235                 240 


Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn Asn 
                245                 250                 255     


Lys Asp Lys Phe Pro Val Ser Arg Gln Glu Val Lys Asp Gly Glu Thr 
            260                 265                 270         


Lys Lys Glu Ala Gln Glu Leu Glu Glu Asp Arg Ala Glu Gly Leu Thr 
        275                 280                 285             


Asn 
    


<210>  5137
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HOXD9__Homo_sapiens__NP_055028

<400>  5137

Met Leu Gly Gly Ser Ala Gly Arg Leu Lys Met Ser Ser Ser Gly Thr 
1               5                   10                  15      


Leu Ser Asn Tyr Tyr Val Asp Ser Leu Ile Gly His Glu Gly Asp Glu 
            20                  25                  30          


Val Phe Ala Ala Arg Phe Gly Pro Pro Gly Pro Gly Ala Gln Gly Arg 
        35                  40                  45              


Pro Ala Gly Val Ala Asp Gly Pro Ala Ala Thr Ala Ala Glu Phe Ala 
    50                  55                  60                  


Ser Cys Ser Phe Ala Pro Arg Ser Ala Val Phe Ser Ala Ser Trp Ser 
65                  70                  75                  80  


Ala Val Pro Ser Gln Pro Pro Ala Ala Ala Ala Met Ser Gly Leu Tyr 
                85                  90                  95      


His Pro Tyr Val Pro Pro Pro Pro Leu Ala Ala Ser Ala Ser Glu Pro 
            100                 105                 110         


Gly Arg Tyr Val Arg Ser Trp Met Glu Pro Leu Pro Gly Phe Pro Gly 
        115                 120                 125             


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Pro Gly Arg Gly 
    130                 135                 140                 


Pro Ser Pro Gly Pro Ser Gly Pro Ala Asn Gly Arg His Tyr Gly Ile 
145                 150                 155                 160 


Lys Pro Glu Thr Arg Ala Ala Pro Ala Pro Ala Thr Ala Ala Ser Thr 
                165                 170                 175     


Thr Ser Ser Ser Ser Thr Ser Leu Ser Ser Ser Ser Lys Arg Thr Glu 
            180                 185                 190         


Cys Ser Val Ala Arg Glu Ser Gln Gly Ser Ser Gly Pro Glu Phe Ser 
        195                 200                 205             


Cys Asn Ser Phe Leu Gln Glu Lys Ala Ala Ala Ala Thr Gly Gly Thr 
    210                 215                 220                 


Gly Pro Gly Ala Gly Ile Gly Ala Ala Thr Gly Thr Gly Gly Ser Ser 
225                 230                 235                 240 


Glu Pro Ser Ala Cys Ser Asp His Pro Ile Pro Gly Cys Ser Leu Lys 
                245                 250                 255     


Glu Glu Glu Lys Gln His Ser Gln Pro Gln Gln Gln Gln Leu Asp Pro 
            260                 265                 270         


Asn Asn Pro Ala Ala Asn Trp Ile His Ala Arg Ser Thr Arg Lys Lys 
        275                 280                 285             


Arg Cys Pro Tyr Thr Lys Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe 
    290                 295                 300                 


Leu Phe Asn Met Tyr Leu Thr Arg Asp Arg Arg Tyr Glu Val Ala Arg 
305                 310                 315                 320 


Ile Leu Asn Leu Thr Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg 
                325                 330                 335     


Arg Met Lys Met Lys Lys Met Ser Lys Glu Lys Cys Pro Lys Gly Asp 
            340                 345                 350         


<210>  5138
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HP1BP3__Homo_sapiens__XP_011539836

<400>  5138

Met Pro Ile Arg Arg Thr Val Asn Ser Thr Arg Glu Thr Pro Pro Lys 
1               5                   10                  15      


Ser Lys Leu Ala Glu Gly Glu Glu Glu Lys Pro Glu Pro Asp Ile Ser 
            20                  25                  30          


Ser Glu Glu Ser Val Ser Thr Val Glu Glu Gln Glu Asn Glu Thr Pro 
        35                  40                  45              


Pro Ala Thr Ser Ser Glu Ala Glu Gln Pro Lys Gly Glu Pro Glu Asn 
    50                  55                  60                  


Glu Glu Lys Glu Glu Asn Lys Ser Ser Glu Glu Thr Lys Lys Asp Glu 
65                  70                  75                  80  


Lys Asp Gln Ser Lys Glu Lys Glu Lys Lys Val Lys Lys Thr Ile Pro 
                85                  90                  95      


Ser Trp Ala Thr Leu Ser Ala Ser Gln Leu Ala Arg Ala Gln Lys Gln 
            100                 105                 110         


Thr Pro Met Ala Ser Ser Pro Arg Pro Lys Met Asp Ala Ile Leu Thr 
        115                 120                 125             


Glu Ala Ile Lys Ala Cys Phe Gln Lys Ser Gly Ala Ser Val Val Ala 
    130                 135                 140                 


Ile Arg Lys Tyr Ile Ile His Lys Tyr Pro Ser Leu Glu Leu Glu Arg 
145                 150                 155                 160 


Arg Gly Tyr Leu Leu Lys Gln Ala Leu Lys Arg Glu Leu Asn Arg Gly 
                165                 170                 175     


Val Ile Lys Gln Val Lys Gly Lys Gly Ala Ser Gly Ser Phe Val Val 
            180                 185                 190         


Val Gln Lys Ser Arg Lys Thr Pro Gln Lys Ser Arg Asn Arg Lys Asn 
        195                 200                 205             


Arg Ser Ser Ala Val Asp Pro Glu Pro Gln Val Lys Leu Glu Asp Val 
    210                 215                 220                 


Leu Pro Leu Ala Phe Thr Arg Leu Cys Glu Pro Lys Glu Ala Ser Tyr 
225                 230                 235                 240 


Ser Leu Ile Arg Lys Tyr Val Ser Gln Tyr Tyr Pro Lys Leu Arg Val 
                245                 250                 255     


Asp Ile Arg Pro Gln Leu Leu Lys Asn Ala Leu Gln Arg Ala Val Glu 
            260                 265                 270         


Arg Gly Gln Leu Glu Gln Ile Thr Gly Lys Gly Ala Ser Gly Thr Phe 
        275                 280                 285             


Gln Leu Lys Lys Ser Gly Glu Lys Pro Leu Leu Gly Gly Ser Leu Met 
    290                 295                 300                 


Glu Tyr Ala Ile Leu Ser Ala Ile Ala Ala Met Asn Glu Pro Lys Thr 
305                 310                 315                 320 


Cys Ser Thr Thr Ala Leu Lys Lys Tyr Val Leu Glu Asn His Pro Gly 
                325                 330                 335     


Thr Asn Ser Asn Tyr Gln Met His Leu Leu Lys Lys Thr Leu Gln Lys 
            340                 345                 350         


Cys Glu Lys Asn Gly Trp Met Glu Gln Ile Ser Gly Lys Gly Phe Ser 
        355                 360                 365             


Gly Thr Phe Gln Leu Cys Phe Pro Tyr Tyr Pro Ser Pro Gly Val Leu 
    370                 375                 380                 


Phe Pro Lys Lys Glu Pro Asp Asp Ser Arg Asp Glu Asp Glu Asp Glu 
385                 390                 395                 400 


Asp Glu Ser Ser Glu Glu Asp Ser Glu Asp Glu Glu Pro Pro Pro Lys 
                405                 410                 415     


Arg Arg Leu Gln Lys Lys Thr Pro Ala Lys Ser Pro Gly Lys Ala Ala 
            420                 425                 430         


Ser Val Lys Gln Arg Gly Ser Lys Pro Ala Pro Lys Val Ser Ala Ala 
        435                 440                 445             


Gln Arg Gly Lys Ala Arg Pro Leu Pro Lys Lys Ala Pro Pro Lys Ala 
    450                 455                 460                 


Lys Thr Pro Ala Lys Lys Thr Arg Pro Ser Ser Thr Val Ile Lys Lys 
465                 470                 475                 480 


Pro Ser Gly Gly Ser Ser Lys Lys Pro Ala Thr Ser Ala Arg Lys Glu 
                485                 490                 495     


Val Lys Leu Pro Gly Lys Gly Lys Ser Thr Met Lys Lys Ser Phe Arg 
            500                 505                 510         


Val Lys Lys 
        515 


<210>  5139
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPCAL1__Homo_sapiens__XP_011508650

<400>  5139

Met Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Val Leu Gln Asp Leu 
1               5                   10                  15      


Arg Glu Asn Thr Glu Phe Thr Asp His Glu Leu Gln Glu Trp Tyr Lys 
            20                  25                  30          


Gly Phe Leu Lys Asp Cys Pro Thr Gly His Leu Thr Val Asp Glu Phe 
        35                  40                  45              


Lys Lys Ile Tyr Ala Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe 
    50                  55                  60                  


Ala Glu His Val Phe Arg Thr Phe Asp Thr Asn Gly Asp Gly Thr Ile 
65                  70                  75                  80  


Asp Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Lys 
                85                  90                  95      


Leu Glu Gln Lys Leu Lys Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly 
            100                 105                 110         


Asn Gly Tyr Ile Ser Arg Ser Glu Met Leu Glu Ile Val Gln Ala Ile 
        115                 120                 125             


Tyr Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr 
    130                 135                 140                 


Pro Glu Lys Arg Thr Asp Lys Ile Phe Arg Gln Met Asp Thr Asn Asn 
145                 150                 155                 160 


Asp Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp 
                165                 170                 175     


Pro Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Ser Gln 
            180                 185                 190         


Phe 
    


<210>  5140
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPD__Homo_sapiens__NP_001165464

<400>  5140

Met Gly Phe Glu Pro Leu Ala Tyr Arg Gly Leu Glu Thr Gly Ser Arg 
1               5                   10                  15      


Glu Val Val Ser His Val Ile Lys Gln Gly Lys Ile Val Phe Val Leu 
            20                  25                  30          


Ser Ser Ala Leu Asn Pro Trp Asn Lys Glu Met Gly Asp His Leu Val 
        35                  40                  45              


Lys His Gly Asp Gly Val Lys Asp Ile Ala Phe Glu Val Glu Asp Cys 
    50                  55                  60                  


Asp Tyr Ile Val Gln Lys Ala Arg Glu Arg Gly Ala Lys Ile Met Arg 
65                  70                  75                  80  


Glu Pro Trp Val Glu Gln Asp Lys Phe Gly Lys Val Lys Phe Ala Val 
                85                  90                  95      


Leu Gln Thr Tyr Gly Asp Thr Thr His Thr Leu Val Glu Lys Met Asn 
            100                 105                 110         


Tyr Ile Gly Gln Phe Leu Pro Gly Tyr Glu Ala Pro Ala Phe Met Asp 
        115                 120                 125             


Pro Leu Leu Pro Lys Leu Pro Lys Cys Ser Leu Glu Met Ile Asp His 
    130                 135                 140                 


Ile Val Gly Asn Gln Pro Asp Gln Glu Met Val Ser Ala Ser Glu Trp 
145                 150                 155                 160 


Tyr Leu Lys Asn Leu Gln Phe His Arg Phe Trp Ser Val Asp Asp Thr 
                165                 170                 175     


Gln Val His Thr Glu Tyr Ser Ser Leu Arg Ser Ile Val Val Ala Asn 
            180                 185                 190         


Tyr Glu Glu Ser Ile Lys Met Pro Ile Asn Glu Pro Ala Pro Gly Lys 
        195                 200                 205             


Lys Lys Ser Gln Ile Gln Glu Tyr Val Asp Tyr Asn Gly Gly Ala Gly 
    210                 215                 220                 


Val Gln His Ile Ala Leu Lys Thr Glu Asp Ile Ile Thr Ala Ile Arg 
225                 230                 235                 240 


His Leu Arg Glu Arg Gly Leu Glu Phe Leu Ser Val Pro Ser Thr Tyr 
                245                 250                 255     


Tyr Lys Gln Leu Arg Glu Lys Leu Lys Thr Ala Lys Ile Lys Val Lys 
            260                 265                 270         


Glu Asn Ile Asp Ala Leu Glu Glu Leu Lys Ile Leu Val Asp Tyr Asp 
        275                 280                 285             


Glu Lys Gly Tyr Leu Leu Gln Ile Phe Thr Lys Pro Val Gln Asp Arg 
    290                 295                 300                 


Pro Thr Leu Phe Leu Glu Val Ile Gln Arg His Asn His Gln Gly Phe 
305                 310                 315                 320 


Gly Ala Gly Asn Phe Asn Ser Leu Phe Lys Ala Phe Glu Glu Glu Gln 
                325                 330                 335     


Asn Leu Arg Gly Asn Leu Thr Asn Met Glu Thr Asn Gly Val Val Pro 
            340                 345                 350         


Gly Met 
        


<210>  5141
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPGD__Homo_sapiens__NP_000851

<400>  5141

Met His Val Asn Gly Lys Val Ala Leu Val Thr Gly Ala Ala Gln Gly 
1               5                   10                  15      


Ile Gly Arg Ala Phe Ala Glu Ala Leu Leu Leu Lys Gly Ala Lys Val 
            20                  25                  30          


Ala Leu Val Asp Trp Asn Leu Glu Ala Gly Val Gln Cys Lys Ala Ala 
        35                  40                  45              


Leu Asp Glu Gln Phe Glu Pro Gln Lys Thr Leu Phe Ile Gln Cys Asp 
    50                  55                  60                  


Val Ala Asp Gln Gln Gln Leu Arg Asp Thr Phe Arg Lys Val Val Asp 
65                  70                  75                  80  


His Phe Gly Arg Leu Asp Ile Leu Val Asn Asn Ala Gly Val Asn Asn 
                85                  90                  95      


Glu Lys Asn Trp Glu Lys Thr Leu Gln Ile Asn Leu Val Ser Val Ile 
            100                 105                 110         


Ser Gly Thr Tyr Leu Gly Leu Asp Tyr Met Ser Lys Gln Asn Gly Gly 
        115                 120                 125             


Glu Gly Gly Ile Ile Ile Asn Met Ser Ser Leu Ala Gly Leu Met Pro 
    130                 135                 140                 


Val Ala Gln Gln Pro Val Tyr Cys Ala Ser Lys His Gly Ile Val Gly 
145                 150                 155                 160 


Phe Thr Arg Ser Ala Ala Leu Ala Ala Asn Leu Met Asn Ser Gly Val 
                165                 170                 175     


Arg Leu Asn Ala Ile Cys Pro Gly Phe Val Asn Thr Ala Ile Leu Glu 
            180                 185                 190         


Ser Ile Glu Lys Glu Glu Asn Met Gly Gln Tyr Ile Glu Tyr Lys Asp 
        195                 200                 205             


His Ile Lys Asp Met Ile Lys Tyr Tyr Gly Ile Leu Asp Pro Pro Leu 
    210                 215                 220                 


Ile Ala Asn Gly Leu Ile Thr Leu Ile Glu Asp Asp Ala Leu Asn Gly 
225                 230                 235                 240 


Ala Ile Met Lys Ile Thr Thr Ser Lys Gly Ile His Phe Gln Asp Tyr 
                245                 250                 255     


Asp Thr Thr Pro Phe Gln Ala Lys Thr Gln 
            260                 265     


<210>  5142
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPGDS__Homo_sapiens__NP_055300

<400>  5142

Met Pro Asn Tyr Lys Leu Thr Tyr Phe Asn Met Arg Gly Arg Ala Glu 
1               5                   10                  15      


Ile Ile Arg Tyr Ile Phe Ala Tyr Leu Asp Ile Gln Tyr Glu Asp His 
            20                  25                  30          


Arg Ile Glu Gln Ala Asp Trp Pro Glu Ile Lys Ser Thr Leu Pro Phe 
        35                  40                  45              


Gly Lys Ile Pro Ile Leu Glu Val Asp Gly Leu Thr Leu His Gln Ser 
    50                  55                  60                  


Leu Ala Ile Ala Arg Tyr Leu Thr Lys Asn Thr Asp Leu Ala Gly Asn 
65                  70                  75                  80  


Thr Glu Met Glu Gln Cys His Val Asp Ala Ile Val Asp Thr Leu Asp 
                85                  90                  95      


Asp Phe Met Ser Cys Phe Pro Trp Ala Glu Lys Lys Gln Asp Val Lys 
            100                 105                 110         


Glu Gln Met Phe Asn Glu Leu Leu Thr Tyr Asn Ala Pro His Leu Met 
        115                 120                 125             


Gln Asp Leu Asp Thr Tyr Leu Gly Gly Arg Glu Trp Leu Ile Gly Asn 
    130                 135                 140                 


Ser Val Thr Trp Ala Asp Phe Tyr Trp Glu Ile Cys Ser Thr Thr Leu 
145                 150                 155                 160 


Leu Val Phe Lys Pro Asp Leu Leu Asp Asn His Pro Arg Leu Val Thr 
                165                 170                 175     


Leu Arg Lys Lys Val Gln Ala Ile Pro Ala Val Ala Asn Trp Ile Lys 
            180                 185                 190         


Arg Arg Pro Gln Thr Lys Leu 
        195                 


<210>  5143
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HP__Homo_sapiens__NP_001119574

<400>  5143

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro 
                85                  90                  95      


Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly 
            100                 105                 110         


Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr 
        115                 120                 125             


Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn 
    130                 135                 140                 


Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro 
145                 150                 155                 160 


Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys 
                165                 170                 175     


Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys 
            180                 185                 190         


Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu 
        195                 200                 205             


Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly 
    210                 215                 220                 


Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val 
225                 230                 235                 240 


Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly 
                245                 250                 255     


Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln 
            260                 265                 270         


Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln 
        275                 280                 285             


Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp 
    290                 295                 300                 


Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys 
305                 310                 315                 320 


Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile 
                325                 330                 335     


Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345         


<210>  5144
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPN__Homo_sapiens__NP_892028

<400>  5144

Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu 
    


<210>  5145
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPR__Homo_sapiens__NP_066275

<400>  5145

Met Ser Asp Leu Gly Ala Val Ile Ser Leu Leu Leu Trp Gly Arg Gln 
1               5                   10                  15      


Leu Phe Ala Leu Tyr Ser Gly Asn Asp Val Thr Asp Ile Ser Asp Asp 
            20                  25                  30          


Arg Phe Pro Lys Pro Pro Glu Ile Ala Asn Gly Tyr Val Glu His Leu 
        35                  40                  45              


Phe Arg Tyr Gln Cys Lys Asn Tyr Tyr Arg Leu Arg Thr Glu Gly Asp 
    50                  55                  60                  


Gly Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val 
65                  70                  75                  80  


Gly Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn 
                85                  90                  95      


Pro Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys 
            100                 105                 110         


Gly Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr 
        115                 120                 125             


Thr Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys 
    130                 135                 140                 


Asn Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala 
145                 150                 155                 160 


Pro Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu 
                165                 170                 175     


Lys Val Val Leu His Pro Asn Tyr His Gln Val Asp Ile Gly Leu Ile 
            180                 185                 190         


Lys Leu Lys Gln Lys Val Leu Val Asn Glu Arg Val Met Pro Ile Cys 
        195                 200                 205             


Leu Pro Ser Lys Asn Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser 
    210                 215                 220                 


Gly Trp Gly Gln Ser Asp Asn Phe Lys Leu Thr Asp His Leu Lys Tyr 
225                 230                 235                 240 


Val Met Leu Pro Val Ala Asp Gln Tyr Asp Cys Ile Thr His Tyr Glu 
                245                 250                 255     


Gly Ser Thr Cys Pro Lys Trp Lys Ala Pro Lys Ser Pro Val Gly Val 
            260                 265                 270         


Gln Pro Ile Leu Asn Glu His Thr Phe Cys Val Gly Met Ser Lys Tyr 
        275                 280                 285             


Gln Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His 
    290                 295                 300                 


Asp Leu Glu Glu Asp Thr Trp Tyr Ala Ala Gly Ile Leu Ser Phe Asp 
305                 310                 315                 320 


Lys Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser 
                325                 330                 335     


Ile Gln His Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345             


<210>  5146
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPRT1__Homo_sapiens__NP_000185

<400>  5146

Met Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly 
1               5                   10                  15      


Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu 
            20                  25                  30          


Glu Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg 
        35                  40                  45              


Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala 
    50                  55                  60                  


Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp 
65                  70                  75                  80  


Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr 
                85                  90                  95      


Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly 
            100                 105                 110         


Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys 
        115                 120                 125             


Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln 
    130                 135                 140                 


Thr Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val 
145                 150                 155                 160 


Ala Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro 
                165                 170                 175     


Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala 
            180                 185                 190         


Leu Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile 
        195                 200                 205             


Ser Glu Thr Gly Lys Ala Lys Tyr Lys Ala 
    210                 215             


<210>  5147
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPS1__Homo_sapiens__NP_000186

<400>  5147

Met Lys Cys Val Leu Val Ala Thr Glu Gly Ala Glu Val Leu Phe Tyr 
1               5                   10                  15      


Trp Thr Asp Gln Glu Phe Glu Glu Ser Leu Arg Leu Lys Phe Gly Gln 
            20                  25                  30          


Ser Glu Asn Glu Glu Glu Glu Leu Pro Ala Leu Glu Asp Gln Leu Ser 
        35                  40                  45              


Thr Leu Leu Ala Pro Val Ile Ile Ser Ser Met Thr Met Leu Glu Lys 
    50                  55                  60                  


Leu Ser Asp Thr Tyr Thr Cys Phe Ser Thr Glu Asn Gly Asn Phe Leu 
65                  70                  75                  80  


Tyr Val Leu His Leu Phe Gly Glu Cys Leu Phe Ile Ala Ile Asn Gly 
                85                  90                  95      


Asp His Thr Glu Ser Glu Gly Asp Leu Arg Arg Lys Leu Tyr Val Leu 
            100                 105                 110         


Lys Tyr Leu Phe Glu Val His Phe Gly Leu Val Thr Val Asp Gly His 
        115                 120                 125             


Leu Ile Arg Lys Glu Leu Arg Pro Pro Asp Leu Ala Gln Arg Val Gln 
    130                 135                 140                 


Leu Trp Glu His Phe Gln Ser Leu Leu Trp Thr Tyr Ser Arg Leu Arg 
145                 150                 155                 160 


Glu Gln Glu Gln Cys Phe Ala Val Glu Ala Leu Glu Arg Leu Ile His 
                165                 170                 175     


Pro Gln Leu Cys Glu Leu Cys Ile Glu Ala Leu Glu Arg His Val Ile 
            180                 185                 190         


Gln Ala Val Asn Thr Ser Pro Glu Arg Gly Gly Glu Glu Ala Leu His 
        195                 200                 205             


Ala Phe Leu Leu Val His Ser Lys Leu Leu Ala Phe Tyr Ser Ser His 
    210                 215                 220                 


Ser Ala Ser Ser Leu Arg Pro Ala Asp Leu Leu Ala Leu Ile Leu Leu 
225                 230                 235                 240 


Val Gln Asp Leu Tyr Pro Ser Glu Ser Thr Ala Glu Asp Asp Ile Gln 
                245                 250                 255     


Pro Ser Pro Arg Arg Ala Arg Ser Ser Gln Asn Ile Pro Val Gln Gln 
            260                 265                 270         


Ala Trp Ser Pro His Ser Thr Gly Pro Thr Gly Gly Ser Ser Ala Glu 
        275                 280                 285             


Thr Glu Thr Asp Ser Phe Ser Leu Pro Glu Glu Tyr Phe Thr Pro Ala 
    290                 295                 300                 


Pro Ser Pro Gly Asp Gln Ser Ser Gly Ser Thr Ile Trp Leu Glu Gly 
305                 310                 315                 320 


Gly Thr Pro Pro Met Asp Ala Leu Gln Ile Ala Glu Asp Thr Leu Gln 
                325                 330                 335     


Thr Leu Val Pro His Cys Pro Val Pro Ser Gly Pro Arg Arg Ile Phe 
            340                 345                 350         


Leu Asp Ala Asn Val Lys Glu Ser Tyr Cys Pro Leu Val Pro His Thr 
        355                 360                 365             


Met Tyr Cys Leu Pro Leu Trp Gln Gly Ile Asn Leu Val Leu Leu Thr 
    370                 375                 380                 


Arg Ser Pro Ser Ala Pro Leu Ala Leu Val Leu Ser Gln Leu Met Asp 
385                 390                 395                 400 


Gly Phe Ser Met Leu Glu Lys Lys Leu Lys Glu Gly Pro Glu Pro Gly 
                405                 410                 415     


Ala Ser Leu Arg Ser Gln Pro Leu Val Gly Asp Leu Arg Gln Arg Met 
            420                 425                 430         


Asp Lys Phe Val Lys Asn Arg Gly Ala Gln Glu Ile Gln Ser Thr Trp 
        435                 440                 445             


Leu Glu Phe Lys Ala Lys Ala Phe Ser Lys Ser Glu Pro Gly Ser Ser 
    450                 455                 460                 


Trp Glu Leu Leu Gln Ala Cys Gly Lys Leu Lys Arg Gln Leu Cys Ala 
465                 470                 475                 480 


Ile Tyr Arg Leu Asn Phe Leu Thr Thr Ala Pro Ser Arg Gly Gly Pro 
                485                 490                 495     


His Leu Pro Gln His Leu Gln Asp Gln Val Gln Arg Leu Met Arg Glu 
            500                 505                 510         


Lys Leu Thr Asp Trp Lys Asp Phe Leu Leu Val Lys Ser Arg Arg Asn 
        515                 520                 525             


Ile Thr Met Val Ser Tyr Leu Glu Asp Phe Pro Gly Leu Val His Phe 
    530                 535                 540                 


Ile Tyr Val Asp Arg Thr Thr Gly Gln Met Val Ala Pro Ser Leu Asn 
545                 550                 555                 560 


Cys Ser Gln Lys Thr Ser Ser Glu Leu Gly Lys Gly Pro Leu Ala Ala 
                565                 570                 575     


Phe Val Lys Thr Lys Val Trp Ser Leu Ile Gln Leu Ala Arg Arg Tyr 
            580                 585                 590         


Leu Gln Lys Gly Tyr Thr Thr Leu Leu Phe Gln Glu Gly Asp Phe Tyr 
        595                 600                 605             


Cys Ser Tyr Phe Leu Trp Phe Glu Asn Asp Met Gly Tyr Lys Leu Gln 
    610                 615                 620                 


Met Ile Glu Val Pro Val Leu Ser Asp Asp Ser Val Pro Ile Gly Met 
625                 630                 635                 640 


Leu Gly Gly Asp Tyr Tyr Arg Lys Leu Leu Arg Tyr Tyr Ser Lys Asn 
                645                 650                 655     


Arg Pro Thr Glu Ala Val Arg Cys Tyr Glu Leu Leu Ala Leu His Leu 
            660                 665                 670         


Ser Val Ile Pro Thr Asp Leu Leu Val Gln Gln Ala Gly Gln Leu Ala 
        675                 680                 685             


Arg Arg Leu Trp Glu Ala Ser Arg Ile Pro Leu Leu 
    690                 695                 700 


<210>  5148
<211>  1004
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPS3__Homo_sapiens__NP_115759

<400>  5148

Met Val Gln Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val 
1               5                   10                  15      


Pro Cys Lys Leu Glu Pro Asp Arg Phe Cys Gly Gly Gly Arg Asp Ala 
            20                  25                  30          


Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Ala Gly 
        35                  40                  45              


Gln Glu Leu Cys Gln Pro Arg Cys Ala Phe Ser Thr Leu Gly Arg Val 
    50                  55                  60                  


Leu Arg Leu Ala Tyr Ser Glu Ala Gly Asp Tyr Leu Val Ala Ile Glu 
65                  70                  75                  80  


Glu Lys Asn Lys Ala Thr Phe Leu Arg Ala Tyr Val Asn Trp Arg Asn 
                85                  90                  95      


Lys Arg Thr Glu Asn Ser Arg Val Cys Ile Arg Met Ile Gly His Asn 
            100                 105                 110         


Val Glu Gly Pro Phe Ser Lys Ala Phe Arg Asp Gln Met Tyr Ile Ile 
        115                 120                 125             


Glu Met Pro Leu Ser Glu Ala Pro Leu Cys Ile Ser Cys Cys Pro Val 
    130                 135                 140                 


Lys Gly Asp Leu Leu Val Gly Cys Thr Asn Lys Leu Val Leu Phe Ser 
145                 150                 155                 160 


Leu Lys Tyr Gln Ile Ile Asn Glu Glu Phe Ser Leu Leu Asp Phe Glu 
                165                 170                 175     


Arg Ser Leu Ile Ile His Ile Asp Asn Ile Thr Pro Val Glu Val Ser 
            180                 185                 190         


Phe Cys Val Gly Tyr Val Ala Val Met Ser Asp Leu Glu Val Leu Ile 
        195                 200                 205             


Val Lys Leu Glu Ser Gly Pro Lys Asn Gly Glu Arg Val His His His 
    210                 215                 220                 


Pro His Lys Thr Asn Asn Arg Ile Arg Arg Thr Glu Glu Gly Ile Ser 
225                 230                 235                 240 


Asn Glu Ile Ser Gln Leu Glu Ser Asp Asp Phe Val Ile Cys Gln Lys 
                245                 250                 255     


Pro Leu Glu Leu Leu Gly Glu Lys Ser Glu Gln Ser Gly Leu Ser Val 
            260                 265                 270         


Thr Leu Glu Ser Thr Gly Leu Ala Asp Glu Lys Arg Lys Tyr Ser His 
        275                 280                 285             


Phe Gln His Leu Leu Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr 
    290                 295                 300                 


Val Leu Ser Asp Asp Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile 
305                 310                 315                 320 


Tyr Gln Thr Gly Ser Leu Thr Ser Asp Gly Lys Asn Leu Ser Gln Glu 
                325                 330                 335     


Lys Glu Leu Leu Ser Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly 
            340                 345                 350         


Tyr Leu Tyr Met Val Val Lys Ser Val Glu Leu Met Ser Val Tyr Gln 
        355                 360                 365             


Tyr Pro Glu Lys Ser Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His 
    370                 375                 380                 


Val Ile Thr Ser Asn Asn Leu Gln Cys Phe Thr Val Arg Cys Ser Ala 
385                 390                 395                 400 


Ala Ala Ala Arg Glu Glu Asp Pro Tyr Met Asp Thr Thr Leu Lys Ala 
                405                 410                 415     


Cys Pro Pro Val Ser Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe 
            420                 425                 430         


Ile Gly Leu Lys Ala Ile Cys His Phe Lys Asn His Ile Ile Leu Leu 
        435                 440                 445             


Thr Lys Ala Glu Pro Glu Ala Ile Pro Glu Arg Arg Gln Ser Pro Lys 
    450                 455                 460                 


Arg Leu Leu Ser Arg Lys Asp Thr Ser Val Lys Ile Lys Ile Pro Pro 
465                 470                 475                 480 


Val Ala Glu Ala Gly Trp Asn Leu Tyr Ile Val Asn Thr Ile Ser Pro 
                485                 490                 495     


Val Gln Leu Tyr Lys Glu Met Val Asp Tyr Ser Asn Thr Tyr Lys Thr 
            500                 505                 510         


Val Lys Thr Gln Ser Cys Ile His Leu Leu Ser Glu Ala His Leu Leu 
        515                 520                 525             


Val Arg Ala Ala Leu Met Asp Ala Ser Gln Leu Glu Pro Gly Glu Lys 
    530                 535                 540                 


Ala Glu Leu Leu Glu Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp 
545                 550                 555                 560 


Cys Tyr Ser Arg Leu Asp Ser Gln His Ser His Leu Thr Leu Pro Tyr 
                565                 570                 575     


Tyr Lys Met Ser Gly Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp 
            580                 585                 590         


Trp Thr Val Glu Asp Gly Leu Gln Lys Tyr Glu Arg Gly Leu Ile Phe 
        595                 600                 605             


Tyr Ile Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu 
    610                 615                 620                 


Glu Leu Ala Ala Lys Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys 
625                 630                 635                 640 


Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro 
                645                 650                 655     


Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser 
            660                 665                 670         


Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly 
        675                 680                 685             


Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys 
    690                 695                 700                 


Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg 
705                 710                 715                 720 


Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr 
                725                 730                 735     


Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn 
            740                 745                 750         


Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala 
        755                 760                 765             


Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala 
    770                 775                 780                 


Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe 
785                 790                 795                 800 


Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro 
                805                 810                 815     


Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser 
            820                 825                 830         


His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp 
        835                 840                 845             


Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Ser 
    850                 855                 860                 


Leu Ile Cys Gly Pro Ser Phe Asp Ile Ala Ser Ile Ile Pro Phe Leu 
865                 870                 875                 880 


Glu Pro Leu Ser Glu Asp Thr Ile Ala Gly Leu Ser Val His Val Leu 
                885                 890                 895     


Cys Arg Thr Arg Leu Lys Glu Tyr Glu Gln Cys Ile Asp Ile Leu Leu 
            900                 905                 910         


Glu Arg Cys Pro Glu Ala Val Ile Pro Tyr Ala Asn His Glu Leu Lys 
        915                 920                 925             


Glu Glu Asn Arg Thr Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys 
    930                 935                 940                 


Gln Arg Ile Lys Cys Gly Gly Glu Lys Tyr Gln Leu Tyr Leu Ser Ser 
945                 950                 955                 960 


Leu Lys Glu Thr Leu Ser Ile Val Ala Val Glu Leu Glu Leu Lys Asp 
                965                 970                 975     


Phe Met Asn Val Leu Pro Glu Asp Gly Thr Ala Thr Phe Phe Leu Pro 
            980                 985                 990         


Tyr Leu Leu Tyr Cys Ser Arg Lys  Lys Pro Leu Thr 
        995                 1000                 


<210>  5149
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPS4__Homo_sapiens__NP_071364

<400>  5149

Met Ala Thr Ser Thr Ser Thr Glu Ala Lys Ser Ala Ser Trp Trp Asn 
1               5                   10                  15      


Tyr Phe Phe Leu Tyr Asp Gly Ser Lys Val Lys Glu Glu Gly Asp Pro 
            20                  25                  30          


Thr Arg Ala Gly Ile Cys Tyr Phe Tyr Pro Ser Gln Thr Leu Leu Asp 
        35                  40                  45              


Gln Gln Glu Leu Leu Cys Gly Gln Ile Ala Gly Val Val Arg Cys Val 
    50                  55                  60                  


Ser Asp Ile Ser Asp Ser Pro Pro Thr Leu Val Arg Leu Arg Lys Leu 
65                  70                  75                  80  


Lys Phe Ala Ile Lys Val Asp Gly Asp Tyr Leu Trp Val Leu Gly Cys 
                85                  90                  95      


Ala Val Glu Leu Pro Asp Val Ser Cys Lys Arg Phe Leu Asp Gln Leu 
            100                 105                 110         


Val Gly Phe Phe Asn Phe Tyr Asn Gly Pro Val Ser Leu Ala Tyr Glu 
        115                 120                 125             


Asn Cys Ser Gln Glu Glu Leu Ser Thr Glu Trp Asp Thr Phe Ile Glu 
    130                 135                 140                 


Gln Ile Leu Lys Asn Thr Ser Asp Leu His Lys Ile Phe Asn Ser Leu 
145                 150                 155                 160 


Trp Asn Leu Asp Gln Thr Lys Val Glu Pro Leu Leu Leu Leu Lys Ala 
                165                 170                 175     


Ala Arg Ile Leu Gln Thr Cys Gln Arg Ser Pro His Ile Leu Ala Gly 
            180                 185                 190         


Cys Ile Leu Tyr Lys Gly Leu Ile Val Ser Thr Gln Leu Pro Pro Ser 
        195                 200                 205             


Leu Thr Ala Lys Val Leu Leu His Arg Thr Ala Pro Gln Glu Gln Arg 
    210                 215                 220                 


Leu Pro Thr Gly Glu Asp Ala Pro Gln Glu His Gly Ala Ala Leu Pro 
225                 230                 235                 240 


Pro Asn Val Gln Ile Ile Pro Val Phe Val Thr Lys Glu Glu Ala Ile 
                245                 250                 255     


Ser Leu His Glu Phe Pro Val Glu Gln Met Thr Arg Ser Leu Ala Ser 
            260                 265                 270         


Pro Ala Gly Leu Gln Asp Gly Ser Ala Gln His His Pro Lys Gly Gly 
        275                 280                 285             


Ser Thr Ser Ala Leu Lys Glu Asn Ala Thr Gly His Val Glu Ser Met 
    290                 295                 300                 


Ala Trp Thr Thr Pro Asp Pro Thr Ser Pro Asp Glu Ala Cys Pro Asp 
305                 310                 315                 320 


Gly Arg Lys Glu Asn Gly Cys Leu Ser Gly His Asp Leu Glu Ser Ile 
                325                 330                 335     


Arg Pro Ala Gly Leu His Asn Ser Ala Arg Gly Glu Val Leu Gly Leu 
            340                 345                 350         


Ser Ser Ser Leu Gly Lys Glu Leu Val Phe Leu Gln Glu Glu Leu Asp 
        355                 360                 365             


Leu Ser Glu Ile His Ile Pro Glu Ala Gln Glu Val Glu Met Ala Ser 
    370                 375                 380                 


Gly His Phe Ala Phe Leu His Val Pro Val Pro Asp Gly Arg Ala Pro 
385                 390                 395                 400 


Tyr Cys Lys Ala Ser Leu Ser Ala Ser Ser Ser Leu Glu Pro Thr Pro 
                405                 410                 415     


Pro Glu Asp Thr Ala Ile Ser Ser Leu Arg Pro Pro Ser Ala Pro Glu 
            420                 425                 430         


Met Leu Thr Gln His Gly Ala Gln Glu Gln Leu Glu Asp His Pro Gly 
        435                 440                 445             


His Ser Ser Gln Ala Pro Ile Pro Arg Ala Asp Pro Leu Pro Arg Arg 
    450                 455                 460                 


Thr Arg Arg Pro Leu Leu Leu Pro Arg Leu Asp Pro Gly Gln Arg Gly 
465                 470                 475                 480 


Asn Lys Leu Pro Thr Gly Glu Gln Gly Leu Asp Glu Asp Val Asp Gly 
                485                 490                 495     


Val Cys Glu Ser His Ala Ala Pro Gly Leu Glu Cys Ser Ser Gly Ser 
            500                 505                 510         


Ala Asn Cys Gln Gly Ala Gly Pro Ser Ala Asp Gly Ile Ser Ser Arg 
        515                 520                 525             


Leu Thr Pro Ala Glu Ser Cys Met Gly Leu Val Arg Met Asn Leu Tyr 
    530                 535                 540                 


Thr His Cys Val Lys Gly Leu Val Leu Ser Leu Leu Ala Glu Glu Pro 
545                 550                 555                 560 


Leu Leu Gly Asp Ser Ala Ala Ile Glu Glu Val Tyr His Ser Ser Leu 
                565                 570                 575     


Ala Ser Leu Asn Gly Leu Glu Val His Leu Lys Glu Thr Leu Pro Arg 
            580                 585                 590         


Asp Glu Ala Ala Ser Thr Ser Ser Thr Tyr Asn Phe Thr His Tyr Asp 
        595                 600                 605             


Arg Ile Gln Ser Leu Leu Met Ala Asn Leu Pro Gln Val Ala Thr Pro 
    610                 615                 620                 


Gln Asp Arg Arg Phe Leu Gln Ala Val Ser Leu Met His Ser Glu Phe 
625                 630                 635                 640 


Ala Gln Leu Pro Ala Leu Tyr Glu Met Thr Val Arg Asn Ala Ser Thr 
                645                 650                 655     


Ala Val Tyr Ala Cys Cys Asn Pro Ile Gln Glu Thr Tyr Phe Gln Gln 
            660                 665                 670         


Leu Ala Pro Ala Ala Arg Ser Ser Gly Phe Pro Asn Pro Gln Asp Gly 
        675                 680                 685             


Ala Phe Ser Leu Ser Gly Lys Ala Lys Gln Lys Leu Leu Lys His Gly 
    690                 695                 700                 


Val Asn Leu Leu 
705             


<210>  5150
<211>  1129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPS5__Homo_sapiens__NP_852608

<400>  5150

Met Ala Phe Val Pro Val Ile Pro Glu Ser Tyr Ser His Val Leu Ala 
1               5                   10                  15      


Glu Phe Glu Ser Leu Asp Pro Leu Leu Ser Ala Leu Arg Leu Asp Ser 
            20                  25                  30          


Ser Arg Leu Lys Cys Thr Ser Ile Ala Val Ser Arg Lys Trp Leu Ala 
        35                  40                  45              


Leu Gly Ser Ser Gly Gly Gly Leu His Leu Ile Gln Lys Glu Gly Trp 
    50                  55                  60                  


Lys His Arg Leu Phe Leu Ser His Arg Glu Gly Ala Ile Ser Gln Val 
65                  70                  75                  80  


Ala Cys Cys Leu His Asp Asp Asp Tyr Val Ala Val Ala Thr Ser Gln 
                85                  90                  95      


Gly Leu Val Val Val Trp Glu Leu Asn Gln Glu Arg Arg Gly Lys Pro 
            100                 105                 110         


Glu Gln Met Tyr Val Ser Ser Glu His Lys Gly Arg Arg Val Thr Ala 
        115                 120                 125             


Leu Cys Trp Asp Thr Ala Ile Leu Arg Val Phe Val Gly Asp His Ala 
    130                 135                 140                 


Gly Lys Val Ser Ala Ile Lys Leu Asn Thr Ser Lys Gln Ala Lys Ala 
145                 150                 155                 160 


Ala Ala Ala Phe Val Met Phe Pro Val Gln Thr Ile Thr Thr Val Asp 
                165                 170                 175     


Ser Cys Val Val Gln Leu Asp Tyr Leu Asp Gly Arg Leu Leu Ile Ser 
            180                 185                 190         


Ser Leu Thr Arg Ser Phe Leu Cys Asp Thr Glu Arg Glu Lys Phe Trp 
        195                 200                 205             


Lys Ile Gly Asn Lys Glu Arg Asp Gly Glu Tyr Gly Ala Cys Phe Phe 
    210                 215                 220                 


Pro Gly Arg Cys Ser Gly Gly Gln Gln Pro Leu Ile Tyr Cys Ala Arg 
225                 230                 235                 240 


Pro Gly Ser Arg Met Trp Glu Val Asn Phe Asp Gly Glu Val Ile Ser 
                245                 250                 255     


Thr His Gln Phe Lys Lys Leu Leu Ser Leu Pro Pro Leu Pro Val Ile 
            260                 265                 270         


Thr Leu Arg Ser Glu Pro Gln Tyr Asp His Thr Ala Gly Ser Ser Gln 
        275                 280                 285             


Ser Leu Ser Phe Pro Lys Leu Leu His Leu Ser Glu His Cys Val Leu 
    290                 295                 300                 


Thr Trp Thr Glu Arg Gly Ile Tyr Ile Phe Ile Pro Gln Asn Val Gln 
305                 310                 315                 320 


Val Leu Leu Trp Ser Glu Val Lys Asp Ile Gln Asp Val Ala Val Cys 
                325                 330                 335     


Arg Asn Glu Leu Phe Cys Leu His Leu Asn Gly Lys Val Ser His Leu 
            340                 345                 350         


Ser Leu Ile Ser Val Glu Arg Cys Val Glu Arg Leu Leu Arg Arg Gly 
        355                 360                 365             


Leu Trp Asn Leu Ala Ala Arg Thr Cys Cys Leu Phe Gln Asn Ser Val 
    370                 375                 380                 


Ile Ala Ser Arg Ala Arg Lys Thr Leu Thr Ala Asp Lys Leu Glu His 
385                 390                 395                 400 


Leu Lys Ser Gln Leu Asp His Gly Thr Tyr Asn Asp Leu Ile Ser Gln 
                405                 410                 415     


Leu Glu Glu Leu Ile Leu Lys Phe Glu Pro Leu Asp Ser Ala Cys Ser 
            420                 425                 430         


Ser Arg Arg Ser Ser Ile Ser Ser His Glu Ser Phe Ser Ile Leu Asp 
        435                 440                 445             


Ser Gly Ile Tyr Arg Ile Ile Ser Ser Arg Arg Gly Ser Gln Ser Asp 
    450                 455                 460                 


Glu Asp Ser Cys Ser Leu His Ser Gln Thr Leu Ser Glu Asp Glu Arg 
465                 470                 475                 480 


Phe Lys Glu Phe Thr Ser Gln Gln Glu Glu Asp Leu Pro Asp Gln Cys 
                485                 490                 495     


Cys Gly Ser His Gly Asn Glu Asp Asn Val Ser His Ala Pro Val Met 
            500                 505                 510         


Phe Glu Thr Asp Lys Asn Glu Thr Phe Leu Pro Phe Gly Ile Pro Leu 
        515                 520                 525             


Pro Phe Arg Ser Pro Ser Pro Leu Val Ser Leu Gln Ala Val Lys Glu 
    530                 535                 540                 


Ser Val Ser Ser Phe Val Arg Lys Thr Thr Glu Lys Ile Gly Thr Leu 
545                 550                 555                 560 


His Thr Ser Pro Asp Leu Lys Val Arg Pro Glu Leu Arg Gly Asp Glu 
                565                 570                 575     


Gln Ser Cys Glu Glu Asp Val Ser Ser Asp Thr Cys Pro Lys Glu Glu 
            580                 585                 590         


Asp Thr Glu Glu Glu Lys Glu Val Thr Ser Pro Pro Pro Glu Glu Asp 
        595                 600                 605             


Arg Phe Gln Glu Leu Lys Val Ala Thr Ala Glu Ala Met Thr Lys Leu 
    610                 615                 620                 


Gln Asp Pro Leu Val Leu Phe Glu Ser Glu Ser Leu Arg Met Val Leu 
625                 630                 635                 640 


Gln Glu Trp Leu Ser His Leu Glu Lys Thr Phe Ala Met Lys Asp Phe 
                645                 650                 655     


Ser Gly Val Ser Asp Thr Asp Asn Ser Ser Met Lys Leu Asn Gln Asp 
            660                 665                 670         


Val Leu Leu Val Asn Glu Ser Lys Lys Gly Ile Leu Asp Glu Asp Asn 
        675                 680                 685             


Glu Lys Glu Lys Arg Asp Ser Leu Gly Asn Glu Glu Ser Val Asp Lys 
    690                 695                 700                 


Thr Ala Cys Glu Cys Val Arg Ser Pro Arg Glu Ser Leu Asp Asp Leu 
705                 710                 715                 720 


Phe Gln Ile Cys Ser Pro Cys Ala Ile Ala Ser Gly Leu Arg Asn Asp 
                725                 730                 735     


Leu Ala Glu Leu Thr Thr Leu Cys Leu Glu Leu Asn Val Leu Asn Ser 
            740                 745                 750         


Lys Ile Lys Ser Thr Ser Gly His Val Asp His Thr Leu Gln Gln Tyr 
        755                 760                 765             


Ser Pro Glu Ile Leu Ala Cys Gln Phe Leu Lys Lys Tyr Phe Phe Leu 
    770                 775                 780                 


Leu Asn Leu Lys Arg Ala Lys Glu Ser Ile Lys Leu Ser Tyr Ser Asn 
785                 790                 795                 800 


Ser Pro Ser Val Trp Asp Thr Phe Ile Glu Gly Leu Lys Glu Met Ala 
                805                 810                 815     


Ser Ser Asn Pro Val Tyr Met Glu Met Glu Lys Gly Asp Leu Pro Thr 
            820                 825                 830         


Arg Leu Lys Leu Leu Asp Asp Glu Val Pro Phe Asp Ser Pro Leu Leu 
        835                 840                 845             


Val Val Tyr Ala Thr Arg Leu Tyr Glu Lys Phe Gly Glu Ser Ala Leu 
    850                 855                 860                 


Arg Ser Leu Ile Lys Phe Phe Pro Ser Ile Leu Pro Ser Asp Ile Ile 
865                 870                 875                 880 


Gln Leu Cys His His His Pro Ala Glu Phe Leu Ala Tyr Leu Asp Ser 
                885                 890                 895     


Leu Val Lys Ser Arg Pro Glu Asp Gln Arg Ser Ser Phe Leu Glu Ser 
            900                 905                 910         


Leu Leu Gln Pro Glu Ser Leu Arg Leu Asp Trp Leu Leu Leu Ala Val 
        915                 920                 925             


Ser Leu Asp Ala Pro Pro Ser Thr Ser Thr Met Asp Asp Glu Gly Tyr 
    930                 935                 940                 


Pro Arg Pro His Ser His Leu Leu Ser Trp Gly Tyr Ser Gln Leu Ile 
945                 950                 955                 960 


Leu His Leu Ile Lys Leu Pro Ala Asp Phe Ile Thr Lys Glu Lys Met 
                965                 970                 975     


Thr Asp Ile Cys Arg Ser Cys Gly Phe Trp Pro Gly Tyr Leu Ile Leu 
            980                 985                 990         


Cys Leu Glu Leu Glu Arg Arg Arg  Glu Ala Phe Thr Asn  Ile Val Tyr 
        995                 1000                 1005             


Leu Asn  Asp Met Ser Leu Met  Glu Gly Asp Asn Gly  Trp Ile Pro 
    1010                 1015                 1020             


Glu Thr  Val Glu Glu Trp Lys  Leu Leu Leu His Leu  Ile Gln Ser 
    1025                 1030                 1035             


Lys Ser  Thr Arg Pro Ala Pro  Gln Glu Ser Leu Asn  Gly Ser Leu 
    1040                 1045                 1050             


Ser Asp  Gly Pro Ser Pro Ile  Asn Val Glu Asn Val  Ala Leu Leu 
    1055                 1060                 1065             


Leu Ala  Lys Ala Met Gly Pro  Asp Arg Ala Trp Ser  Leu Leu Gln 
    1070                 1075                 1080             


Glu Cys  Gly Leu Ala Leu Glu  Leu Ser Glu Lys Phe  Thr Arg Thr 
    1085                 1090                 1095             


Cys Asp  Ile Leu Arg Ile Ala  Glu Lys Arg Gln Arg  Ala Leu Ile 
    1100                 1105                 1110             


Gln Ser  Met Leu Glu Lys Cys  Asp Arg Phe Leu Trp  Ser Gln Gln 
    1115                 1120                 1125             


Ala 
    


<210>  5151
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPS6__Homo_sapiens__NP_079023

<400>  5151

Met Lys Arg Ser Gly Thr Leu Arg Leu Leu Ser Asp Leu Ser Ala Phe 
1               5                   10                  15      


Gly Gly Ala Ala Arg Leu Arg Glu Leu Val Ala Gly Asp Ser Ala Val 
            20                  25                  30          


Arg Val Arg Gly Ser Pro Asp Gly Arg His Leu Leu Leu Leu Arg Pro 
        35                  40                  45              


Pro Gly Ala Val Ala Pro Gln Leu Leu Val Ala Ser Arg Gly Pro Gly 
    50                  55                  60                  


Ala Glu Leu Glu Arg Ala Trp Pro Ala Gly Gln Pro Ser Pro Leu Asp 
65                  70                  75                  80  


Ala Phe Phe Leu Pro Trp Pro Ala Arg Pro Ala Leu Val Leu Val Trp 
                85                  90                  95      


Glu Ser Gly Leu Ala Glu Val Trp Gly Ala Gly Val Gly Pro Gly Trp 
            100                 105                 110         


Arg Pro Leu Gln Ser Thr Glu Leu Cys Pro Gly Gly Gly Ala Arg Val 
        115                 120                 125             


Val Ala Val Ala Ala Leu Arg Gly Arg Leu Val Trp Cys Glu Glu Arg 
    130                 135                 140                 


Gln Ala Arg Ala Glu Gly Pro Ser Gly Ser Pro Ala Ala Ala Phe Ser 
145                 150                 155                 160 


His Cys Val Cys Val Arg Thr Leu Glu Pro Ser Gly Glu Ala Ser Thr 
                165                 170                 175     


Ser Leu Gly Arg Thr His Val Leu Leu His His Cys Pro Ala Phe Gly 
            180                 185                 190         


Leu Leu Ala Ser Cys Arg Gln Leu Phe Leu Val Pro Thr Ala Thr Thr 
        195                 200                 205             


Trp Pro Gly Val Ala His Val Leu Leu Ile Trp Ser Pro Gly Lys Gly 
    210                 215                 220                 


Lys Val Met Val Ala Ala Pro Arg Leu Gly Leu Ser Tyr Ser Lys Ser 
225                 230                 235                 240 


Leu Asn Pro Gly Arg Gly Asp Thr Trp Asp Phe Arg Thr Leu Leu Arg 
                245                 250                 255     


Gly Leu Pro Gly Leu Leu Ser Pro Arg Glu Pro Leu Ala Val His Thr 
            260                 265                 270         


Trp Ala Pro Thr Pro Gln Gly Leu Leu Leu Leu Asp Phe Gly Gly Thr 
        275                 280                 285             


Val Ser Leu Leu Gln Ser His Gly Gly Thr Arg Ala Val Gly Thr Leu 
    290                 295                 300                 


Gln Glu Ala Pro Val Gly Pro Trp Gly Ser Ala Ala Leu Gly Thr Phe 
305                 310                 315                 320 


Gln Gly Thr Leu Ala Cys Val Leu Gly Ser Thr Leu Glu Leu Leu Asp 
                325                 330                 335     


Met Gly Ser Gly Gln Leu Leu Glu Arg Lys Val Leu Ser Thr Asp Arg 
            340                 345                 350         


Val His Leu Leu Glu Pro Pro Ala Pro Gly Met Glu Asp Glu Glu Glu 
        355                 360                 365             


Leu Glu Thr Arg Gly Asn Leu Arg Leu Leu Ser Ala Leu Gly Leu Phe 
    370                 375                 380                 


Cys Val Gly Trp Glu Ala Pro Gln Gly Val Glu Leu Pro Ser Ala Lys 
385                 390                 395                 400 


Asp Leu Val Phe Glu Glu Ala Cys Gly Tyr Tyr Gln Arg Arg Ser Leu 
                405                 410                 415     


Arg Gly Ala Gln Leu Thr Pro Glu Glu Leu Arg His Ser Ser Thr Phe 
            420                 425                 430         


Arg Ala Pro Gln Ala Leu Ala Ser Ile Leu Gln Gly His Leu Pro Pro 
        435                 440                 445             


Ser Ala Leu Leu Thr Met Leu Arg Thr Glu Leu Arg Asp Tyr Arg Gly 
    450                 455                 460                 


Leu Glu Gln Leu Lys Ala Gln Leu Val Ala Gly Asp Asp Glu Glu Ala 
465                 470                 475                 480 


Gly Trp Thr Glu Leu Ala Glu Gln Glu Val Ala Arg Leu Leu Arg Thr 
                485                 490                 495     


Glu Leu Ile Gly Asp Gln Leu Ala Gln Leu Asn Thr Val Phe Gln Ala 
            500                 505                 510         


Leu Pro Thr Ala Ala Trp Gly Ala Thr Leu Arg Ala Leu Gln Leu Gln 
        515                 520                 525             


Leu Asp Gly Asn Gly Lys Leu Arg Ser Gln Ala Pro Pro Asp Val Trp 
    530                 535                 540                 


Lys Lys Val Leu Gly Gly Ile Thr Ala Gly Lys Glu Pro Pro Asn Gly 
545                 550                 555                 560 


Ile Leu Pro Pro Phe Glu Leu Leu Cys Gln Cys Leu Cys Gln Leu Glu 
                565                 570                 575     


Pro Arg Trp Leu Pro Pro Phe Val Glu Leu Ala Gln Gln Gln Gly Gly 
            580                 585                 590         


Pro Gly Trp Gly Ala Gly Gly Pro Gly Leu Pro Leu Tyr Arg Arg Ala 
        595                 600                 605             


Leu Ala Val Leu Gly Glu Glu Gly Thr Arg Pro Glu Ala Leu Glu Leu 
    610                 615                 620                 


Glu Leu Leu Leu Ser Ser Gly Arg Pro Lys Ala Val Leu Gln Ala Val 
625                 630                 635                 640 


Gly Gln Leu Val Gln Lys Glu Gln Trp Asp Arg Ala Leu Asp Ala Gly 
                645                 650                 655     


Leu Ala Leu Gly Pro Ser Ser Pro Leu Leu Arg Ser Glu Ile Phe Lys 
            660                 665                 670         


Leu Leu Leu Ala Glu Phe Ala Gln His Arg Arg Leu Asp Ala His Leu 
        675                 680                 685             


Pro Leu Leu Cys Arg Leu Cys Pro Pro Glu Leu Ala Pro Ala Glu Leu 
    690                 695                 700                 


Leu Leu Leu Leu Arg Thr Tyr Leu Pro Asp Glu Val Gly Pro Pro Thr 
705                 710                 715                 720 


Pro Phe Pro Glu Pro Gly Ala Glu Pro Pro Leu Thr Val Gly Leu Leu 
                725                 730                 735     


Lys Ala Leu Leu Glu Gln Thr Gly Ala Gln Gly Trp Leu Ser Gly Pro 
            740                 745                 750         


Val Leu Ser Pro Tyr Glu Asp Ile Leu Trp Asp Pro Ser Thr Pro Pro 
        755                 760                 765             


Pro Thr Pro Pro Arg Asp Leu 
    770                 775 


<210>  5152
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPSE2__Homo_sapiens__NP_001159716

<400>  5152

Met Arg Val Leu Cys Ala Phe Pro Glu Ala Met Pro Ser Ser Asn Ser 
1               5                   10                  15      


Arg Pro Pro Ala Cys Leu Ala Pro Gly Ala Leu Tyr Leu Ala Leu Leu 
            20                  25                  30          


Leu His Leu Ser Leu Ser Ser Gln Ala Gly Asp Arg Arg Pro Leu Pro 
        35                  40                  45              


Val Asp Arg Ala Ala Gly Leu Lys Glu Lys Thr Leu Ile Leu Leu Asp 
    50                  55                  60                  


Val Ser Thr Lys Asn Pro Val Arg Thr Val Asn Glu Asn Phe Leu Ser 
65                  70                  75                  80  


Leu Gln Leu Asp Pro Ser Ile Ile His Asp Gly Trp Leu Asp Phe Leu 
                85                  90                  95      


Ser Ser Lys Arg Leu Val Thr Leu Ala Arg Gly Leu Ser Pro Ala Phe 
            100                 105                 110         


Leu Arg Phe Gly Gly Lys Arg Thr Asp Phe Leu Gln Phe Gln Asn Leu 
        115                 120                 125             


Arg Asn Pro Ala Lys Ser Arg Gly Gly Pro Gly Pro Asp Tyr Tyr Leu 
    130                 135                 140                 


Lys Asn Tyr Glu Asp Asp Ile Val Arg Ser Asp Val Ala Leu Asp Lys 
145                 150                 155                 160 


Gln Lys Gly Cys Lys Ile Ala Gln His Pro Asp Val Met Leu Glu Leu 
                165                 170                 175     


Gln Arg Glu Lys Ala Ala Gln Met His Leu Val Leu Leu Lys Glu Gln 
            180                 185                 190         


Phe Ser Asn Thr Tyr Ser Asn Leu Ile Leu Thr Glu Pro Asn Asn Tyr 
        195                 200                 205             


Arg Thr Met His Gly Arg Ala Val Asn Gly Ser Gln Leu Gly Lys Asp 
    210                 215                 220                 


Tyr Ile Gln Leu Lys Ser Leu Leu Gln Pro Ile Arg Ile Tyr Ser Arg 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Pro Asn Ile Gly Arg Pro Arg Lys Asn Val Ile 
                245                 250                 255     


Ala Leu Leu Asp Gly Phe Met Lys Val Ala Gly Ser Thr Val Asp Ala 
            260                 265                 270         


Val Thr Trp Gln His Cys Tyr Ile Asp Gly Arg Val Val Lys Val Met 
        275                 280                 285             


Asp Phe Leu Lys Thr Arg Leu Leu Asp Thr Leu Ser Asp Gln Ile Arg 
    290                 295                 300                 


Lys Ile Gln Lys Val Val Asn Thr Tyr Thr Pro Gly Lys Lys Ile Trp 
305                 310                 315                 320 


Leu Glu Gly Val Val Thr Thr Ser Ala Gly Gly Thr Asn Asn Leu Ser 
                325                 330                 335     


Asp Ser Tyr Ala Ala Gly Phe Leu Trp Leu Asn Thr Leu Gly Met Leu 
            340                 345                 350         


Ala Asn Gln Gly Ile Asp Val Val Ile Arg His Ser Phe Phe Asp His 
        355                 360                 365             


Gly Tyr Asn His Leu Val Asp Gln Asn Phe Asn Pro Leu Pro Asp Tyr 
    370                 375                 380                 


Trp Leu Ser Leu Leu Tyr Lys Arg Leu Ile Gly Pro Lys Val Leu Ala 
385                 390                 395                 400 


Val His Val Ala Gly Leu Gln Arg Lys Pro Arg Pro Gly Arg Val Ile 
                405                 410                 415     


Arg Asp Lys Leu Arg Ile Tyr Ala His Cys Thr Asn His His Asn His 
            420                 425                 430         


Asn Tyr Val Arg Gly Ser Ile Thr Leu Phe Ile Ile Asn Leu His Arg 
        435                 440                 445             


Ser Arg Lys Lys Ile Lys Leu Ala Gly Thr Leu Arg Asp Lys Leu Val 
    450                 455                 460                 


His Gln Tyr Leu Leu Gln Pro Tyr Gly Gln Glu Gly Leu Lys Ser Lys 
465                 470                 475                 480 


Ser Val Gln Leu Asn Gly Gln Pro Leu Val Met Val Asp Asp Gly Thr 
                485                 490                 495     


Leu Pro Glu Leu Lys Pro Arg Pro Leu Arg Ala Gly Arg Thr Leu Val 
            500                 505                 510         


Ile Pro Pro Val Thr Met Gly Phe Tyr Val Val Lys Asn Val Asn Ala 
        515                 520                 525             


Leu Ala Cys Arg Tyr Arg 
    530                 


<210>  5153
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPSE__Homo_sapiens__NP_001092010

<400>  5153

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  5154
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPX__Homo_sapiens__XP_005252940

<400>  5154

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 
            20                  25                  30          


Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 
        35                  40                  45              


Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 
    50                  55                  60                  


Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys 
65                  70                  75                  80  


Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 
                85                  90                  95      


Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 
            100                 105                 110         


Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 
        115                 120                 125             


Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 
    130                 135                 140                 


Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu 
145                 150                 155                 160 


Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 
                165                 170                 175     


Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 
            180                 185                 190         


Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 
        195                 200                 205             


Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 
    210                 215                 220                 


Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn 
225                 230                 235                 240 


Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 
                245                 250                 255     


Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 
            260                 265                 270         


Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 
        275                 280                 285             


Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 
    290                 295                 300                 


Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu 
305                 310                 315                 320 


Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 
                325                 330                 335     


Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 
            340                 345                 350         


His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 
        355                 360                 365             


Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 
    370                 375                 380                 


Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His 
385                 390                 395                 400 


Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 
                405                 410                 415     


Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 
            420                 425                 430         


Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 
        435                 440                 445             


Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 
    450                 455                 460         


<210>  5155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRAS__Homo_sapiens__NP_001123914

<400>  5155

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  5156
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRASLS__Homo_sapiens__NP_065119

<400>  5156

Met Val Arg Ala Ser Cys Arg Leu Gly Ser Ala Arg Thr Pro Ser Pro 
1               5                   10                  15      


Ala Arg Arg Pro Pro Gly Val Arg Ala Ser Gln Ser Arg Gly Gly Ala 
            20                  25                  30          


Ala Gly Thr Val Ser Ala Trp Arg Arg Trp Cys Trp Arg Trp Pro Trp 
        35                  40                  45              


Arg Thr Ala Pro Ser Asp Gly Trp Arg Leu Pro Pro Gly Cys Leu Pro 
    50                  55                  60                  


Gly Thr Asp Gly Val Val Pro Arg Pro Pro Ala Ala Arg Ser Ala Ala 
65                  70                  75                  80  


Ala Arg Pro Arg Glu Thr Pro Gly His Thr Gln Leu Pro Pro Gly Ala 
                85                  90                  95      


Arg Arg Arg Pro Arg Leu Glu Ser Glu Met Ala Phe Asn Asp Cys Phe 
            100                 105                 110         


Ser Leu Asn Tyr Pro Gly Asn Pro Cys Pro Gly Asp Leu Ile Glu Val 
        115                 120                 125             


Phe Arg Pro Gly Tyr Gln His Trp Ala Leu Tyr Leu Gly Asp Gly Tyr 
    130                 135                 140                 


Val Ile Asn Ile Ala Pro Val Asp Gly Ile Pro Ala Ser Phe Thr Ser 
145                 150                 155                 160 


Ala Lys Ser Val Phe Ser Ser Lys Ala Leu Val Lys Met Gln Leu Leu 
                165                 170                 175     


Lys Asp Val Val Gly Asn Asp Thr Tyr Arg Ile Asn Asn Lys Tyr Asp 
            180                 185                 190         


Glu Thr Tyr Pro Pro Leu Pro Val Glu Glu Ile Ile Lys Arg Ser Glu 
        195                 200                 205             


Phe Val Ile Gly Gln Glu Val Ala Tyr Asn Leu Leu Val Asn Asn Cys 
    210                 215                 220                 


Glu His Phe Val Thr Leu Leu Arg Tyr Gly Glu Gly Val Ser Glu Gln 
225                 230                 235                 240 


Ala Asn Arg Ala Ile Ser Thr Val Glu Phe Val Thr Ala Ala Val Gly 
                245                 250                 255     


Val Phe Ser Phe Leu Gly Leu Phe Pro Lys Gly Gln Arg Ala Lys Tyr 
            260                 265                 270         


Tyr 
    


<210>  5157
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRC__Homo_sapiens__NP_002143

<400>  5157

Met Gly His His Arg Pro Trp Leu His Ala Ser Val Leu Trp Ala Gly 
1               5                   10                  15      


Val Ala Ser Leu Leu Leu Pro Pro Ala Met Thr Gln Gln Leu Arg Gly 
            20                  25                  30          


Asp Gly Leu Gly Phe Arg Asn Arg Asn Asn Ser Thr Gly Val Ala Gly 
        35                  40                  45              


Leu Ser Glu Glu Ala Ser Ala Glu Leu Arg His His Leu His Ser Pro 
    50                  55                  60                  


Arg Asp His Pro Asp Glu Asn Lys Asp Val Ser Thr Glu Asn Gly His 
65                  70                  75                  80  


His Phe Trp Ser His Pro Asp Arg Glu Lys Glu Asp Glu Asp Val Ser 
                85                  90                  95      


Lys Glu Tyr Gly His Leu Leu Pro Gly His Arg Ser Gln Asp His Lys 
            100                 105                 110         


Val Gly Asp Glu Gly Val Ser Gly Glu Glu Val Phe Ala Glu His Gly 
        115                 120                 125             


Gly Gln Ala Arg Gly His Arg Gly His Gly Ser Glu Asp Thr Glu Asp 
    130                 135                 140                 


Ser Ala Glu His Arg His His Leu Pro Ser His Arg Ser His Ser His 
145                 150                 155                 160 


Gln Asp Glu Asp Glu Asp Glu Val Val Ser Ser Glu His His His His 
                165                 170                 175     


Ile Leu Arg His Gly His Arg Gly His Asp Gly Glu Asp Asp Glu Gly 
            180                 185                 190         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ser Thr Glu 
        195                 200                 205             


Tyr Gly His Gln Ala His Arg His Arg Gly His Gly Ser Glu Glu Asp 
    210                 215                 220                 


Glu Asp Val Ser Asp Gly His His His His Gly Pro Ser His Arg His 
225                 230                 235                 240 


Gln Gly His Glu Glu Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
                245                 250                 255     


Asp Asp Asp Asp Asp Val Ser Ile Glu Tyr Arg His Gln Ala His Arg 
            260                 265                 270         


His Gln Gly His Gly Ile Glu Glu Asp Glu Asp Val Ser Asp Gly His 
        275                 280                 285             


His His Arg Asp Pro Ser His Arg His Arg Ser His Glu Glu Asp Asp 
    290                 295                 300                 


Asn Asp Asp Asp Asp Val Ser Thr Glu Tyr Gly His Gln Ala His Arg 
305                 310                 315                 320 


His Gln Asp His Arg Lys Glu Glu Val Glu Ala Val Ser Gly Glu His 
                325                 330                 335     


His His His Val Pro Asp His Arg His Gln Gly His Arg Asp Glu Glu 
            340                 345                 350         


Glu Asp Glu Asp Val Ser Thr Glu Arg Trp His Gln Gly Pro Gln His 
        355                 360                 365             


Val His His Gly Leu Val Asp Glu Glu Glu Glu Glu Glu Glu Ile Thr 
    370                 375                 380                 


Val Gln Phe Gly His Tyr Val Ala Ser His Gln Pro Arg Gly His Lys 
385                 390                 395                 400 


Ser Asp Glu Glu Asp Phe Gln Asp Glu Tyr Lys Thr Glu Val Pro His 
                405                 410                 415     


His His His His Arg Val Pro Arg Glu Glu Asp Glu Glu Val Ser Ala 
            420                 425                 430         


Glu Leu Gly His Gln Ala Pro Ser His Arg Gln Ser His Gln Asp Glu 
        435                 440                 445             


Glu Thr Gly His Gly Gln Arg Gly Ser Ile Lys Glu Met Ser His His 
    450                 455                 460                 


Pro Pro Gly His Thr Val Val Lys Asp Arg Ser His Leu Arg Lys Asp 
465                 470                 475                 480 


Asp Ser Glu Glu Glu Lys Glu Lys Glu Glu Asp Pro Gly Ser His Glu 
                485                 490                 495     


Glu Asp Asp Glu Ser Ser Glu Gln Gly Glu Lys Gly Thr His His Gly 
            500                 505                 510         


Ser Arg Asp Gln Glu Asp Glu Glu Asp Glu Glu Glu Gly His Gly Leu 
        515                 520                 525             


Ser Leu Asn Gln Glu Glu Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu 
    530                 535                 540                 


Glu Glu Glu Asp Glu Glu Arg Arg Glu Glu Arg Ala Glu Val Gly Ala 
545                 550                 555                 560 


Pro Leu Ser Pro Asp His Ser Glu Glu Glu Glu Glu Glu Glu Glu Gly 
                565                 570                 575     


Leu Glu Glu Asp Glu Pro Arg Phe Thr Ile Ile Pro Asn Pro Leu Asp 
            580                 585                 590         


Arg Arg Glu Glu Ala Gly Gly Ala Ser Ser Glu Glu Glu Ser Gly Glu 
        595                 600                 605             


Asp Thr Gly Pro Gln Asp Ala Gln Glu Tyr Gly Asn Tyr Gln Pro Gly 
    610                 615                 620                 


Ser Leu Cys Gly Tyr Cys Ser Phe Cys Asn Arg Cys Thr Glu Cys Glu 
625                 630                 635                 640 


Ser Cys His Cys Asp Glu Glu Asn Met Gly Glu His Cys Asp Gln Cys 
                645                 650                 655     


Gln His Cys Gln Phe Cys Tyr Leu Cys Pro Leu Val Cys Glu Thr Val 
            660                 665                 670         


Cys Ala Pro Gly Ser Tyr Val Asp Tyr Phe Ser Ser Ser Leu Tyr Gln 
        675                 680                 685             


Ala Leu Ala Asp Met Leu Glu Thr Pro Glu Pro 
    690                 695                 


<210>  5158
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRG__Homo_sapiens__NP_000403

<400>  5158

Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser 
1               5                   10                  15      


Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 
            20                  25                  30          


Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 
        35                  40                  45              


Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 
    50                  55                  60                  


Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val 
65                  70                  75                  80  


Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 
                85                  90                  95      


Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 
            100                 105                 110         


Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 
        115                 120                 125             


Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 
    130                 135                 140                 


Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys 
145                 150                 155                 160 


Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 
                165                 170                 175     


Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 
            180                 185                 190         


Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 
        195                 200                 205             


Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 
    210                 215                 220                 


Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn 
225                 230                 235                 240 


Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 
                245                 250                 255     


Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 
            260                 265                 270         


Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 
        275                 280                 285             


Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 
    290                 295                 300                 


Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu 
305                 310                 315                 320 


Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 
                325                 330                 335     


Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 
            340                 345                 350         


Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 
        355                 360                 365             


His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 
    370                 375                 380                 


His Pro His Gly His His Pro His Gly His His Pro His Gly His His 
385                 390                 395                 400 


Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 
                405                 410                 415     


Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 
            420                 425                 430         


Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 
        435                 440                 445             


Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 
    450                 455                 460                 


Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe 
465                 470                 475                 480 


Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 
                485                 490                 495     


Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 
            500                 505                 510         


Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 
        515                 520                 525 


<210>  5159
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRH1__Homo_sapiens__NP_001091683

<400>  5159

Met Ser Leu Pro Asn Ser Ser Cys Leu Leu Glu Asp Lys Met Cys Glu 
1               5                   10                  15      


Gly Asn Lys Thr Thr Met Ala Ser Pro Gln Leu Met Pro Leu Val Val 
            20                  25                  30          


Val Leu Ser Thr Ile Cys Leu Val Thr Val Gly Leu Asn Leu Leu Val 
        35                  40                  45              


Leu Tyr Ala Val Arg Ser Glu Arg Lys Leu His Thr Val Gly Asn Leu 
    50                  55                  60                  


Tyr Ile Val Ser Leu Ser Val Ala Asp Leu Ile Val Gly Ala Val Val 
65                  70                  75                  80  


Met Pro Met Asn Ile Leu Tyr Leu Leu Met Ser Lys Trp Ser Leu Gly 
                85                  90                  95      


Arg Pro Leu Cys Leu Phe Trp Leu Ser Met Asp Tyr Val Ala Ser Thr 
            100                 105                 110         


Ala Ser Ile Phe Ser Val Phe Ile Leu Cys Ile Asp Arg Tyr Arg Ser 
        115                 120                 125             


Val Gln Gln Pro Leu Arg Tyr Leu Lys Tyr Arg Thr Lys Thr Arg Ala 
    130                 135                 140                 


Ser Ala Thr Ile Leu Gly Ala Trp Phe Leu Ser Phe Leu Trp Val Ile 
145                 150                 155                 160 


Pro Ile Leu Gly Trp Asn His Phe Met Gln Gln Thr Ser Val Arg Arg 
                165                 170                 175     


Glu Asp Lys Cys Glu Thr Asp Phe Tyr Asp Val Thr Trp Phe Lys Val 
            180                 185                 190         


Met Thr Ala Ile Ile Asn Phe Tyr Leu Pro Thr Leu Leu Met Leu Trp 
        195                 200                 205             


Phe Tyr Ala Lys Ile Tyr Lys Ala Val Arg Gln His Cys Gln His Arg 
    210                 215                 220                 


Glu Leu Ile Asn Arg Ser Leu Pro Ser Phe Ser Glu Ile Lys Leu Arg 
225                 230                 235                 240 


Pro Glu Asn Pro Lys Gly Asp Ala Lys Lys Pro Gly Lys Glu Ser Pro 
                245                 250                 255     


Trp Glu Val Leu Lys Arg Lys Pro Lys Asp Ala Gly Gly Gly Ser Val 
            260                 265                 270         


Leu Lys Ser Pro Ser Gln Thr Pro Lys Glu Met Lys Ser Pro Val Val 
        275                 280                 285             


Phe Ser Gln Glu Asp Asp Arg Glu Val Asp Lys Leu Tyr Cys Phe Pro 
    290                 295                 300                 


Leu Asp Ile Val His Met Gln Ala Ala Ala Glu Gly Ser Ser Arg Asp 
305                 310                 315                 320 


Tyr Val Ala Val Asn Arg Ser His Gly Gln Leu Lys Thr Asp Glu Gln 
                325                 330                 335     


Gly Leu Asn Thr His Gly Ala Ser Glu Ile Ser Glu Asp Gln Met Leu 
            340                 345                 350         


Gly Asp Ser Gln Ser Phe Ser Arg Thr Asp Ser Asp Thr Thr Thr Glu 
        355                 360                 365             


Thr Ala Pro Gly Lys Gly Lys Leu Arg Ser Gly Ser Asn Thr Gly Leu 
    370                 375                 380                 


Asp Tyr Ile Lys Phe Thr Trp Lys Arg Leu Arg Ser His Ser Arg Gln 
385                 390                 395                 400 


Tyr Val Ser Gly Leu His Met Asn Arg Glu Arg Lys Ala Ala Lys Gln 
                405                 410                 415     


Leu Gly Phe Ile Met Ala Ala Phe Ile Leu Cys Trp Ile Pro Tyr Phe 
            420                 425                 430         


Ile Phe Phe Met Val Ile Ala Phe Cys Lys Asn Cys Cys Asn Glu His 
        435                 440                 445             


Leu His Met Phe Thr Ile Trp Leu Gly Tyr Ile Asn Ser Thr Leu Asn 
    450                 455                 460                 


Pro Leu Ile Tyr Pro Leu Cys Asn Glu Asn Phe Lys Lys Thr Phe Lys 
465                 470                 475                 480 


Arg Ile Leu His Ile Arg Ser 
                485         


<210>  5160
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRH2__Homo_sapiens__NP_001124527

<400>  5160

Met Ala Pro Asn Gly Thr Ala Ser Ser Phe Cys Leu Asp Ser Thr Ala 
1               5                   10                  15      


Cys Lys Ile Thr Ile Thr Val Val Leu Ala Val Leu Ile Leu Ile Thr 
            20                  25                  30          


Val Ala Gly Asn Val Val Val Cys Leu Ala Val Gly Leu Asn Arg Arg 
        35                  40                  45              


Leu Arg Asn Leu Thr Asn Cys Phe Ile Val Ser Leu Ala Ile Thr Asp 
    50                  55                  60                  


Leu Leu Leu Gly Leu Leu Val Leu Pro Phe Ser Ala Ile Tyr Gln Leu 
65                  70                  75                  80  


Ser Cys Lys Trp Ser Phe Gly Lys Val Phe Cys Asn Ile Tyr Thr Ser 
                85                  90                  95      


Leu Asp Val Met Leu Cys Thr Ala Ser Ile Leu Asn Leu Phe Met Ile 
            100                 105                 110         


Ser Leu Asp Arg Tyr Cys Ala Val Met Asp Pro Leu Arg Tyr Pro Val 
        115                 120                 125             


Leu Val Thr Pro Val Arg Val Ala Ile Ser Leu Val Leu Ile Trp Val 
    130                 135                 140                 


Ile Ser Ile Thr Leu Ser Phe Leu Ser Ile His Leu Gly Trp Asn Ser 
145                 150                 155                 160 


Arg Asn Glu Thr Ser Lys Gly Asn His Thr Thr Ser Lys Cys Lys Val 
                165                 170                 175     


Gln Val Asn Glu Val Tyr Gly Leu Val Asp Gly Leu Val Thr Phe Tyr 
            180                 185                 190         


Leu Pro Leu Leu Ile Met Cys Ile Thr Tyr Tyr Arg Ile Phe Lys Val 
        195                 200                 205             


Ala Arg Asp Gln Ala Lys Arg Ile Asn His Ile Ser Ser Trp Lys Ala 
    210                 215                 220                 


Ala Thr Ile Arg Glu His Lys Ala Thr Val Thr Leu Ala Ala Val Met 
225                 230                 235                 240 


Gly Ala Phe Ile Ile Cys Trp Phe Pro Tyr Phe Thr Ala Phe Val Tyr 
                245                 250                 255     


Arg Gly Leu Arg Gly Asp Asp Ala Ile Asn Glu Val Leu Glu Ala Ile 
            260                 265                 270         


Val Leu Trp Leu Gly Tyr Ala Asn Ser Ala Leu Asn Pro Ile Leu Tyr 
        275                 280                 285             


Ala Ala Leu Asn Arg Asp Phe Arg Thr Gly Tyr Gln Gln Leu Phe Cys 
    290                 295                 300                 


Cys Arg Leu Ala Asn Arg Asn Ser His Lys Thr Ser Leu Arg Ser Asn 
305                 310                 315                 320 


Ala Ser Gln Leu Ser Arg Thr Gln Ser Arg Glu Pro Arg Gln Gln Glu 
                325                 330                 335     


Glu Lys Pro Leu Lys Leu Gln Val Trp Ser Gly Thr Glu Val Thr Ala 
            340                 345                 350         


Pro Gln Gly Ala Thr Asp Arg Pro Trp Leu Cys Leu Pro Glu Cys Trp 
        355                 360                 365             


Ser Val Glu Leu Thr His Ser Phe Ile His Leu Phe Ile His Ser Phe 
    370                 375                 380                 


Ala Asn Ile His Pro Ile Pro Thr Thr Cys Gln Glu Leu 
385                 390                 395         


<210>  5161
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRH3__Homo_sapiens__NP_009163

<400>  5161

Met Glu Arg Ala Pro Pro Asp Gly Pro Leu Asn Ala Ser Gly Ala Leu 
1               5                   10                  15      


Ala Gly Glu Ala Ala Ala Ala Gly Gly Ala Arg Gly Phe Ser Ala Ala 
            20                  25                  30          


Trp Thr Ala Val Leu Ala Ala Leu Met Ala Leu Leu Ile Val Ala Thr 
        35                  40                  45              


Val Leu Gly Asn Ala Leu Val Met Leu Ala Phe Val Ala Asp Ser Ser 
    50                  55                  60                  


Leu Arg Thr Gln Asn Asn Phe Phe Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Phe Leu Val Gly Ala Phe Cys Ile Pro Leu Tyr Val Pro Tyr Val Leu 
                85                  90                  95      


Thr Gly Arg Trp Thr Phe Gly Arg Gly Leu Cys Lys Leu Trp Leu Val 
            100                 105                 110         


Val Asp Tyr Leu Leu Cys Thr Ser Ser Ala Phe Asn Ile Val Leu Ile 
        115                 120                 125             


Ser Tyr Asp Arg Phe Leu Ser Val Thr Arg Ala Val Ser Tyr Arg Ala 
    130                 135                 140                 


Gln Gln Gly Asp Thr Arg Arg Ala Val Arg Lys Met Leu Leu Val Trp 
145                 150                 155                 160 


Val Leu Ala Phe Leu Leu Tyr Gly Pro Ala Ile Leu Ser Trp Glu Tyr 
                165                 170                 175     


Leu Ser Gly Gly Ser Ser Ile Pro Glu Gly His Cys Tyr Ala Glu Phe 
            180                 185                 190         


Phe Tyr Asn Trp Tyr Phe Leu Ile Thr Ala Ser Thr Leu Glu Phe Phe 
        195                 200                 205             


Thr Pro Phe Leu Ser Val Thr Phe Phe Asn Leu Ser Ile Tyr Leu Asn 
    210                 215                 220                 


Ile Gln Arg Arg Thr Arg Leu Arg Leu Asp Gly Ala Arg Glu Ala Ala 
225                 230                 235                 240 


Gly Pro Glu Pro Pro Pro Glu Ala Gln Pro Ser Pro Pro Pro Pro Pro 
                245                 250                 255     


Gly Cys Trp Gly Cys Trp Gln Lys Gly His Gly Glu Ala Met Pro Leu 
            260                 265                 270         


His Arg Tyr Gly Val Gly Glu Ala Ala Val Gly Ala Glu Ala Gly Glu 
        275                 280                 285             


Ala Thr Leu Gly Gly Gly Gly Gly Gly Gly Ser Val Ala Ser Pro Thr 
    290                 295                 300                 


Ser Ser Ser Gly Ser Ser Ser Arg Gly Thr Glu Arg Pro Arg Ser Leu 
305                 310                 315                 320 


Lys Arg Gly Ser Lys Pro Ser Ala Ser Ser Ala Ser Leu Glu Lys Arg 
                325                 330                 335     


Met Lys Met Val Ser Gln Ser Phe Thr Gln Arg Phe Arg Leu Ser Arg 
            340                 345                 350         


Asp Arg Lys Val Ala Lys Ser Leu Ala Val Ile Val Ser Ile Phe Gly 
        355                 360                 365             


Leu Cys Trp Ala Pro Tyr Thr Leu Leu Met Ile Ile Arg Ala Ala Cys 
    370                 375                 380                 


His Gly His Cys Val Pro Asp Tyr Trp Tyr Glu Thr Ser Phe Trp Leu 
385                 390                 395                 400 


Leu Trp Ala Asn Ser Ala Val Asn Pro Val Leu Tyr Pro Leu Cys His 
                405                 410                 415     


His Ser Phe Arg Arg Ala Phe Thr Lys Leu Leu Cys Pro Gln Lys Leu 
            420                 425                 430         


Lys Ile Gln Pro His Ser Ser Leu Glu His Cys Trp Lys 
        435                 440                 445 


<210>  5162
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRH4__Homo_sapiens__NP_001137300

<400>  5162

Met Pro Asp Thr Asn Ser Thr Ile Asn Leu Ser Leu Ser Thr Arg Val 
1               5                   10                  15      


Thr Leu Ala Phe Phe Met Ser Leu Val Ala Phe Ala Ile Met Leu Gly 
            20                  25                  30          


Asn Ala Leu Val Ile Leu Ala Phe Val Val Asp Lys Asn Leu Arg His 
        35                  40                  45              


Arg Ser Ser Tyr Phe Phe Leu Asn Leu Ala Ile Ser Asp Phe Phe Val 
    50                  55                  60                  


Val Ser Glu Ser Trp Lys Asp Glu Gly Ser Glu Cys Glu Pro Gly Phe 
65                  70                  75                  80  


Phe Ser Glu Trp Tyr Ile Leu Ala Ile Thr Ser Phe Leu Glu Phe Val 
                85                  90                  95      


Ile Pro Val Ile Leu Val Ala Tyr Phe Asn Met Asn Ile Tyr Trp Ser 
            100                 105                 110         


Leu Trp Lys Arg Asp His Leu Ser Arg Cys Gln Ser His Pro Gly Leu 
        115                 120                 125             


Thr Ala Val Ser Ser Asn Ile Cys Gly His Ser Phe Arg Gly Arg Leu 
    130                 135                 140                 


Ser Ser Arg Arg Ser Leu Ser Ala Ser Thr Glu Val Pro Ala Ser Phe 
145                 150                 155                 160 


His Ser Glu Arg Gln Arg Arg Lys Ser Ser Leu Met Phe Ser Ser Arg 
                165                 170                 175     


Thr Lys Met Asn Ser Asn Thr Ile Ala Ser Lys Met Gly Ser Phe Ser 
            180                 185                 190         


Gln Ser Asp Ser Val Ala Leu His Gln Arg Glu His Val Glu Leu Leu 
        195                 200                 205             


Arg Ala Arg Arg Leu Ala Lys Ser Leu Ala Ile Leu Leu Gly Val Phe 
    210                 215                 220                 


Ala Val Cys Trp Ala Pro Tyr Ser Leu Phe Thr Ile Val Leu Ser Phe 
225                 230                 235                 240 


Tyr Ser Ser Ala Thr Gly Pro Lys Ser Val Trp Tyr Arg Ile Ala Phe 
                245                 250                 255     


Trp Leu Gln Trp Phe Asn Ser Phe Val Asn Pro Leu Leu Tyr Pro Leu 
            260                 265                 270         


Cys His Lys Arg Phe Gln Lys Ala Phe Leu Lys Ile Phe Cys Ile Lys 
        275                 280                 285             


Lys Gln Pro Leu Pro Ser Gln His Ser Arg Ser Val Ser Ser 
    290                 295                 300         


<210>  5163
<211>  1189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HR__Homo_sapiens__NP_005135

<400>  5163

Met Glu Ser Thr Pro Ser Phe Leu Lys Gly Thr Pro Thr Trp Glu Lys 
1               5                   10                  15      


Thr Ala Pro Glu Asn Gly Ile Val Arg Gln Glu Pro Gly Ser Pro Pro 
            20                  25                  30          


Arg Asp Gly Leu His His Gly Pro Leu Cys Leu Gly Glu Pro Ala Pro 
        35                  40                  45              


Phe Trp Arg Gly Val Leu Ser Thr Pro Asp Ser Trp Leu Pro Pro Gly 
    50                  55                  60                  


Phe Pro Gln Gly Pro Lys Asp Met Leu Pro Leu Val Glu Gly Glu Gly 
65                  70                  75                  80  


Pro Gln Asn Gly Glu Arg Lys Val Asn Trp Leu Gly Ser Lys Glu Gly 
                85                  90                  95      


Leu Arg Trp Lys Glu Ala Met Leu Thr His Pro Leu Ala Phe Cys Gly 
            100                 105                 110         


Pro Ala Cys Pro Pro Arg Cys Gly Pro Leu Met Pro Glu His Ser Gly 
        115                 120                 125             


Gly His Leu Lys Ser Asp Pro Val Ala Phe Arg Pro Trp His Cys Pro 
    130                 135                 140                 


Phe Leu Leu Glu Thr Lys Ile Leu Glu Arg Ala Pro Phe Trp Val Pro 
145                 150                 155                 160 


Thr Cys Leu Pro Pro Tyr Leu Val Ser Gly Leu Pro Pro Glu His Pro 
                165                 170                 175     


Cys Asp Trp Pro Leu Thr Pro His Pro Trp Val Tyr Ser Gly Gly Gln 
            180                 185                 190         


Pro Lys Val Pro Ser Ala Phe Ser Leu Gly Ser Lys Gly Phe Tyr Tyr 
        195                 200                 205             


Lys Asp Pro Ser Ile Pro Arg Leu Ala Lys Glu Pro Leu Ala Ala Ala 
    210                 215                 220                 


Glu Pro Gly Leu Phe Gly Leu Asn Ser Gly Gly His Leu Gln Arg Ala 
225                 230                 235                 240 


Gly Glu Ala Glu Arg Pro Ser Leu His Gln Arg Asp Gly Glu Met Gly 
                245                 250                 255     


Ala Gly Arg Gln Gln Asn Pro Cys Pro Leu Phe Leu Gly Gln Pro Asp 
            260                 265                 270         


Thr Val Pro Trp Thr Ser Trp Pro Ala Cys Pro Pro Gly Leu Val His 
        275                 280                 285             


Thr Leu Gly Asn Val Trp Ala Gly Pro Gly Asp Gly Asn Leu Gly Tyr 
    290                 295                 300                 


Gln Leu Gly Pro Pro Ala Thr Pro Arg Cys Pro Ser Pro Glu Pro Pro 
305                 310                 315                 320 


Val Thr Gln Arg Gly Cys Cys Ser Ser Tyr Pro Pro Thr Lys Gly Gly 
                325                 330                 335     


Gly Leu Gly Pro Cys Gly Lys Cys Gln Glu Gly Leu Glu Gly Gly Ala 
            340                 345                 350         


Ser Gly Ala Ser Glu Pro Ser Glu Glu Val Asn Lys Ala Ser Gly Pro 
        355                 360                 365             


Arg Ala Cys Pro Pro Ser His His Thr Lys Leu Lys Lys Thr Trp Leu 
    370                 375                 380                 


Thr Arg His Ser Glu Gln Phe Glu Cys Pro Arg Gly Cys Pro Glu Val 
385                 390                 395                 400 


Glu Glu Arg Pro Val Ala Arg Leu Arg Ala Leu Lys Arg Ala Gly Ser 
                405                 410                 415     


Pro Glu Val Gln Gly Ala Met Gly Ser Pro Ala Pro Lys Arg Pro Pro 
            420                 425                 430         


Asp Pro Phe Pro Gly Thr Ala Glu Gln Gly Ala Gly Gly Trp Gln Glu 
        435                 440                 445             


Val Arg Asp Thr Ser Ile Gly Asn Lys Asp Val Asp Ser Gly Gln His 
    450                 455                 460                 


Asp Glu Gln Lys Gly Pro Gln Asp Gly Gln Ala Ser Leu Gln Asp Pro 
465                 470                 475                 480 


Gly Leu Gln Asp Ile Pro Cys Leu Ala Leu Pro Ala Lys Leu Ala Gln 
                485                 490                 495     


Cys Gln Ser Cys Ala Gln Ala Ala Gly Glu Gly Gly Gly His Ala Cys 
            500                 505                 510         


His Ser Gln Gln Val Arg Arg Ser Pro Leu Gly Gly Glu Leu Gln Gln 
        515                 520                 525             


Glu Glu Asp Thr Ala Thr Asn Ser Ser Ser Glu Glu Gly Pro Gly Ser 
    530                 535                 540                 


Gly Pro Asp Ser Arg Leu Ser Thr Gly Leu Ala Lys His Leu Leu Ser 
545                 550                 555                 560 


Gly Leu Gly Asp Arg Leu Cys Arg Leu Leu Arg Arg Glu Arg Glu Ala 
                565                 570                 575     


Leu Ala Trp Ala Gln Arg Glu Gly Gln Gly Pro Ala Val Thr Glu Asp 
            580                 585                 590         


Ser Pro Gly Ile Pro Arg Cys Cys Ser Arg Cys His His Gly Leu Phe 
        595                 600                 605             


Asn Thr His Trp Arg Cys Pro Arg Cys Ser His Arg Leu Cys Val Ala 
    610                 615                 620                 


Cys Gly Arg Val Ala Gly Thr Gly Arg Ala Arg Glu Lys Ala Gly Phe 
625                 630                 635                 640 


Gln Glu Gln Ser Ala Glu Glu Cys Thr Gln Glu Ala Gly His Ala Ala 
                645                 650                 655     


Cys Ser Leu Met Leu Thr Gln Phe Val Ser Ser Gln Ala Leu Ala Glu 
            660                 665                 670         


Leu Ser Thr Ala Met His Gln Val Trp Val Lys Phe Asp Ile Arg Gly 
        675                 680                 685             


His Cys Pro Cys Gln Ala Asp Ala Arg Val Trp Ala Pro Gly Asp Ala 
    690                 695                 700                 


Gly Gln Gln Lys Glu Ser Thr Gln Lys Thr Pro Pro Thr Pro Gln Pro 
705                 710                 715                 720 


Ser Cys Asn Gly Asp Thr His Arg Thr Lys Ser Ile Lys Glu Glu Thr 
                725                 730                 735     


Pro Asp Ser Ala Glu Thr Pro Ala Glu Asp Arg Ala Gly Arg Gly Pro 
            740                 745                 750         


Leu Pro Cys Pro Ser Leu Cys Glu Leu Leu Ala Ser Thr Ala Val Lys 
        755                 760                 765             


Leu Cys Leu Gly His Glu Arg Ile His Met Ala Phe Ala Pro Val Thr 
    770                 775                 780                 


Pro Ala Leu Pro Ser Asp Asp Arg Ile Thr Asn Ile Leu Asp Ser Ile 
785                 790                 795                 800 


Ile Ala Gln Val Val Glu Arg Lys Ile Gln Glu Lys Ala Leu Gly Pro 
                805                 810                 815     


Gly Leu Arg Ala Gly Pro Gly Leu Arg Lys Gly Leu Gly Leu Pro Leu 
            820                 825                 830         


Ser Pro Val Arg Pro Arg Leu Pro Pro Pro Gly Ala Leu Leu Trp Leu 
        835                 840                 845             


Gln Glu Pro Gln Pro Cys Pro Arg Arg Gly Phe His Leu Phe Gln Glu 
    850                 855                 860                 


His Trp Arg Gln Gly Gln Pro Val Leu Val Ser Gly Ile Gln Arg Thr 
865                 870                 875                 880 


Leu Gln Gly Asn Leu Trp Gly Thr Glu Ala Leu Gly Ala Leu Gly Gly 
                885                 890                 895     


Gln Val Gln Ala Leu Ser Pro Leu Gly Pro Pro Gln Pro Ser Ser Leu 
            900                 905                 910         


Gly Ser Thr Thr Phe Trp Glu Gly Phe Ser Trp Pro Glu Leu Arg Pro 
        915                 920                 925             


Lys Ser Asp Glu Gly Ser Val Leu Leu Leu His Arg Ala Leu Gly Asp 
    930                 935                 940                 


Glu Asp Thr Ser Arg Val Glu Asn Leu Ala Ala Ser Leu Pro Leu Pro 
945                 950                 955                 960 


Glu Tyr Cys Ala Leu His Gly Lys Leu Asn Leu Ala Ser Tyr Leu Pro 
                965                 970                 975     


Pro Gly Leu Ala Leu Arg Pro Leu Glu Pro Gln Leu Trp Ala Ala Tyr 
            980                 985                 990         


Gly Val Ser Pro His Arg Gly His  Leu Gly Thr Lys Asn  Leu Cys Val 
        995                 1000                 1005             


Glu Val  Ala Asp Leu Val Ser  Ile Leu Val His Ala  Asp Thr Pro 
    1010                 1015                 1020             


Leu Pro  Ala Trp His Arg Ala  Gln Lys Asp Phe Leu  Ser Gly Leu 
    1025                 1030                 1035             


Asp Gly  Glu Gly Leu Trp Ser  Pro Gly Ser Gln Val  Ser Thr Val 
    1040                 1045                 1050             


Trp His  Val Phe Arg Ala Gln  Asp Ala Gln Arg Ile  Arg Arg Phe 
    1055                 1060                 1065             


Leu Gln  Met Val Cys Pro Ala  Gly Ala Gly Ala Leu  Glu Pro Gly 
    1070                 1075                 1080             


Ala Pro  Gly Ser Cys Tyr Leu  Asp Ala Gly Leu Arg  Arg Arg Leu 
    1085                 1090                 1095             


Arg Glu  Glu Trp Gly Val Ser  Cys Trp Thr Leu Leu  Gln Ala Pro 
    1100                 1105                 1110             


Gly Glu  Ala Val Leu Val Pro  Ala Gly Ala Pro His  Gln Val Gln 
    1115                 1120                 1125             


Gly Leu  Val Ser Thr Val Ser  Val Thr Gln His Phe  Leu Ser Pro 
    1130                 1135                 1140             


Glu Thr  Ser Ala Leu Ser Ala  Gln Leu Cys His Gln  Gly Pro Ser 
    1145                 1150                 1155             


Leu Pro  Pro Asp Cys His Leu  Leu Tyr Ala Gln Met  Asp Trp Ala 
    1160                 1165                 1170             


Val Phe  Gln Ala Val Lys Val  Ala Val Gly Thr Leu  Gln Glu Ala 
    1175                 1180                 1185             


Lys 
    


<210>  5164
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRK__Homo_sapiens__NP_003797

<400>  5164

Met Cys Pro Cys Pro Leu His Arg Gly Arg Gly Pro Pro Ala Val Cys 
1               5                   10                  15      


Ala Cys Ser Ala Gly Arg Leu Gly Leu Arg Ser Ser Ala Ala Gln Leu 
            20                  25                  30          


Thr Ala Ala Arg Leu Lys Ala Leu Gly Asp Glu Leu His Gln Arg Thr 
        35                  40                  45              


Met Trp Arg Arg Arg Ala Arg Ser Arg Arg Ala Pro Ala Pro Gly Ala 
    50                  55                  60                  


Leu Pro Thr Tyr Trp Pro Trp Leu Cys Ala Ala Ala Gln Val Ala Ala 
65                  70                  75                  80  


Leu Ala Ala Trp Leu Leu Gly Arg Arg Asn Leu 
                85                  90      


<210>  5165
<211>  2850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRNR__Homo_sapiens__NP_001009931

<400>  5165

Met Pro Lys Leu Leu Gln Gly Val Ile Thr Val Ile Asp Val Phe Tyr 
1               5                   10                  15      


Gln Tyr Ala Thr Gln His Gly Glu Tyr Asp Thr Leu Asn Lys Ala Glu 
            20                  25                  30          


Leu Lys Glu Leu Leu Glu Asn Glu Phe His Gln Ile Leu Lys Asn Pro 
        35                  40                  45              


Asn Asp Pro Asp Thr Val Asp Ile Ile Leu Gln Ser Leu Asp Arg Asp 
    50                  55                  60                  


His Asn Lys Lys Val Asp Phe Thr Glu Tyr Leu Leu Met Ile Phe Lys 
65                  70                  75                  80  


Leu Val Gln Ala Arg Asn Lys Ile Ile Gly Lys Asp Tyr Cys Gln Val 
                85                  90                  95      


Ser Gly Ser Lys Leu Arg Asp Asp Thr His Gln His Gln Glu Glu Gln 
            100                 105                 110         


Glu Glu Thr Glu Lys Glu Glu Asn Lys Arg Gln Glu Ser Ser Phe Ser 
        115                 120                 125             


His Ser Ser Trp Ser Ala Gly Glu Asn Asp Ser Tyr Ser Arg Asn Val 
    130                 135                 140                 


Arg Gly Ser Leu Lys Pro Gly Thr Glu Ser Ile Ser Arg Arg Leu Ser 
145                 150                 155                 160 


Phe Gln Arg Asp Phe Ser Gly Gln His Asn Ser Tyr Ser Gly Gln Ser 
                165                 170                 175     


Ser Ser Tyr Gly Glu Gln Asn Ser Asp Ser His Gln Ser Ser Gly Arg 
            180                 185                 190         


Gly Gln Cys Gly Ser Gly Ser Gly Gln Ser Pro Asn Tyr Gly Gln His 
        195                 200                 205             


Gly Ser Gly Ser Gly Gln Ser Ser Ser Asn Asp Thr His Gly Ser Gly 
    210                 215                 220                 


Ser Gly Gln Ser Ser Gly Phe Ser Gln His Lys Ser Ser Ser Gly Gln 
225                 230                 235                 240 


Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser Gly His Ser Ser Gly 
                245                 250                 255     


Tyr Gly Gln His Gly Ser Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg 
            260                 265                 270         


His Arg Ser Ser Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser 
        275                 280                 285             


Gly Ser Arg Gln Ser Leu Gly His Gly Arg Gln Gly Ser Gly Ser Arg 
    290                 295                 300                 


Gln Ser Pro Ser His Val Arg His Gly Ser Gly Ser Gly His Ser Ser 
305                 310                 315                 320 


Ser His Gly Gln His Gly Ser Gly Ser Ser Tyr Ser Tyr Ser Arg Gly 
                325                 330                 335     


His Tyr Glu Ser Gly Ser Gly Gln Thr Ser Gly Phe Gly Gln His Glu 
            340                 345                 350         


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Lys His Gly Ser Gly Ser 
        355                 360                 365             


Gly His Ser Ser Ser Gln Gly Gln His Gly Ser Thr Ser Gly Gln Ala 
    370                 375                 380                 


Ser Ser Ser Gly Gln His Gly Ser Ser Ser Arg Gln Ser Ser Ser Tyr 
385                 390                 395                 400 


Gly Gln His Glu Ser Ala Ser Arg His Ser Ser Gly Arg Gly Gln His 
                405                 410                 415     


Ser Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg Gly Ser Gly 
            420                 425                 430         


Ser Gly Gln Ser Pro Ser Ser Gly Gln His Gly Thr Gly Phe Gly Arg 
        435                 440                 445             


Ser Ser Ser Ser Gly Pro Tyr Val Ser Gly Ser Gly Tyr Ser Ser Gly 
    450                 455                 460                 


Phe Gly His His Glu Ser Ser Ser Glu His Ser Ser Gly Tyr Thr Gln 
465                 470                 475                 480 


His Gly Ser Gly Ser Gly His Ser Ser Gly His Gly Gln His Gly Ser 
                485                 490                 495     


Arg Ser Gly Gln Ser Ser Arg Gly Glu Arg Gln Gly Ser Ser Ala Gly 
            500                 505                 510         


Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln Ser Leu 
        515                 520                 525             


Gly His Ser Arg His Gly Ser Gly Ser Gly Gln Ser Pro Ser Pro Ser 
    530                 535                 540                 


Arg Gly Arg His Glu Ser Gly Ser Arg Gln Ser Ser Ser Tyr Gly Pro 
545                 550                 555                 560 


His Gly Tyr Gly Ser Gly Arg Ser Ser Ser Arg Gly Pro Tyr Glu Ser 
                565                 570                 575     


Gly Ser Gly His Ser Ser Gly Leu Gly His Gln Glu Ser Arg Ser Gly 
            580                 585                 590         


Gln Ser Ser Gly Tyr Gly Gln His Gly Ser Ser Ser Gly His Ser Ser 
        595                 600                 605             


Thr His Gly Gln His Gly Ser Thr Ser Gly Gln Ser Ser Ser Cys Gly 
    610                 615                 620                 


Gln His Gly Ala Thr Ser Gly Gln Ser Ser Ser His Gly Gln His Gly 
625                 630                 635                 640 


Ser Gly Ser Ser Gln Ser Ser Arg Tyr Gly Gln Gln Gly Ser Gly Ser 
                645                 650                 655     


Gly Gln Ser Pro Ser Arg Gly Arg His Gly Ser Asp Phe Gly His Ser 
            660                 665                 670         


Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Gly Trp Ser Ser Ser Asn 
        675                 680                 685             


Gly Pro His Gly Ser Val Ser Gly Gln Ser Ser Gly Phe Gly His Lys 
    690                 695                 700                 


Ser Gly Ser Gly Gln Ser Ser Gly Tyr Ser Gln His Gly Ser Gly Ser 
705                 710                 715                 720 


Ser His Ser Ser Gly Tyr Arg Lys His Gly Ser Arg Ser Gly Gln Ser 
                725                 730                 735     


Ser Arg Ser Glu Gln His Gly Ser Ser Ser Gly Leu Ser Ser Ser Tyr 
            740                 745                 750         


Gly Gln His Gly Ser Gly Ser His Gln Ser Ser Gly His Gly Arg Gln 
        755                 760                 765             


Gly Ser Gly Ser Gly His Ser Pro Ser Arg Val Arg His Gly Ser Ser 
    770                 775                 780                 


Ser Gly His Ser Ser Ser His Gly Gln His Gly Ser Gly Thr Ser Cys 
785                 790                 795                 800 


Ser Ser Ser Cys Gly His Tyr Glu Ser Gly Ser Gly Gln Ala Ser Gly 
                805                 810                 815     


Phe Gly Gln His Glu Ser Gly Ser Gly Gln Gly Tyr Ser Gln His Gly 
            820                 825                 830         


Ser Ala Ser Gly His Phe Ser Ser Gln Gly Arg His Gly Ser Thr Ser 
        835                 840                 845             


Gly Gln Ser Ser Ser Ser Gly Gln His Asp Ser Ser Ser Gly Gln Ser 
    850                 855                 860                 


Ser Ser Tyr Gly Gln His Glu Ser Ala Ser His His Ala Ser Gly Arg 
865                 870                 875                 880 


Gly Arg His Gly Ser Gly Ser Gly Gln Ser Pro Gly His Gly Gln Arg 
                885                 890                 895     


Gly Ser Gly Ser Gly Gln Ser Pro Ser Tyr Gly Arg His Gly Ser Gly 
            900                 905                 910         


Ser Gly Arg Ser Ser Ser Ser Gly Arg His Gly Ser Gly Ser Gly Gln 
        915                 920                 925             


Ser Ser Gly Phe Gly His Lys Ser Ser Ser Gly Gln Ser Ser Gly Tyr 
    930                 935                 940                 


Thr Gln His Gly Ser Gly Ser Gly His Ser Ser Ser Tyr Glu Gln His 
945                 950                 955                 960 


Gly Ser Arg Ser Gly Gln Ser Ser Arg Ser Glu Gln His Gly Ser Ser 
                965                 970                 975     


Ser Gly Ser Ser Ser Ser Tyr Gly Gln His Gly Ser Gly Ser Arg Gln 
            980                 985                 990         


Ser Leu Gly His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
        995                 1000                 1005             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    1010                 1015                 1020             


Tyr Gly  Pro Tyr Arg Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    1025                 1030                 1035             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    1040                 1045                 1050             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1055                 1060                 1065             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    1070                 1075                 1080             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    1085                 1090                 1095             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    1100                 1105                 1110             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    1115                 1120                 1125             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    1130                 1135                 1140             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    1145                 1150                 1155             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    1160                 1165                 1170             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    1175                 1180                 1185             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    1190                 1195                 1200             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    1205                 1210                 1215             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    1220                 1225                 1230             


Arg Gln  Gly Ser Gly Ser Gly  His Ser Pro Ser Arg  Gly Arg His 
    1235                 1240                 1245             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    1250                 1255                 1260             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser 
    1265                 1270                 1275             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    1280                 1285                 1290             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    1295                 1300                 1305             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    1310                 1315                 1320             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    1325                 1330                 1335             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    1340                 1345                 1350             


Ala Gly  Ser Gly Gln Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly 
    1355                 1360                 1365             


Ser Gly  His Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    1370                 1375                 1380             


Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser 
    1385                 1390                 1395             


Ser Gly  Phe Gly His His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly 
    1400                 1405                 1410             


Cys Thr  Gln His Gly Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu 
    1415                 1420                 1425             


Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His 
    1430                 1435                 1440             


Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser 
    1445                 1450                 1455             


Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln His Gly  Ser Gly Ser 
    1460                 1465                 1470             


Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser 
    1475                 1480                 1485             


Gly Gln  Ser Ser Ser Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp 
    1490                 1495                 1500             


Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly Ser Ser  His Ser Ser 
    1505                 1510                 1515             


Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr 
    1520                 1525                 1530             


Gly Gln  His Gly Ser Ser Ser  Gly His Ser Ser Thr  His Gly Gln 
    1535                 1540                 1545             


His Gly  Ser Thr Ser Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly 
    1550                 1555                 1560             


Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly Gln His  Gly Ser Gly 
    1565                 1570                 1575             


Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly 
    1580                 1585                 1590             


Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser 
    1595                 1600                 1605             


Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser 
    1610                 1615                 1620             


Ser Gly  Gln His Gly Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly 
    1625                 1630                 1635             


His His  Glu Ser Ser Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His 
    1640                 1645                 1650             


Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    1655                 1660                 1665             


Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser 
    1670                 1675                 1680             


Arg Ser  Ser Ser Arg Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln 
    1685                 1690                 1695             


Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro 
    1700                 1705                 1710             


Ser Arg  Gly Arg His Gly Ser  Gly Leu Gly His Ser  Ser Ser His 
    1715                 1720                 1725             


Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro 
    1730                 1735                 1740             


Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val Phe Gly  Gln His Glu 
    1745                 1750                 1755             


Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly 
    1760                 1765                 1770             


Ser Gly  His Phe Cys Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly 
    1775                 1780                 1785             


Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser 
    1790                 1795                 1800             


Ser Ser  His Gly Gln His Gly  Ser Gly Ser Ser Gln  Ser Ser Ser 
    1805                 1810                 1815             


Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln Ser Pro  Ser Arg Gly 
    1820                 1825                 1830             


Arg His  Gly Ser Gly Ser Gly  His Ser Ser Ser Tyr  Gly Gln His 
    1835                 1840                 1845             


Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser Gly Arg  His Gly Ser 
    1850                 1855                 1860             


Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His His Glu  Ser Ser Ser 
    1865                 1870                 1875             


Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly Ser Gly  Ser Gly His 
    1880                 1885                 1890             


Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg Ser Gly  Gln Ser Ser 
    1895                 1900                 1905             


Arg Gly  Glu Gln His Gly Ser  Ser Ser Gly Ser Ser  Ser Ser Tyr 
    1910                 1915                 1920             


Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser Leu Gly  His Gly Gln 
    1925                 1930                 1935             


His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser Pro Ser  Arg Gly Arg 
    1940                 1945                 1950             


His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser Tyr Gly  Pro Tyr Gly 
    1955                 1960                 1965             


Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly Pro Tyr  Glu Ser Gly 
    1970                 1975                 1980             


Ser Gly  His Ser Ser Gly Leu  Gly His Arg Glu Ser  Arg Ser Gly 
    1985                 1990                 1995             


Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser Ser Ser  Gly His Ser 
    2000                 2005                 2010             


Ser Thr  His Gly Gln His Gly  Ser Ala Ser Gly Gln  Ser Ser Ser 
    2015                 2020                 2025             


Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln Ser Ser  Ser His Gly 
    2030                 2035                 2040             


Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser Gly Tyr  Gly Arg Gln 
    2045                 2050                 2055             


Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His Gly Gln  Arg Gly Ser 
    2060                 2065                 2070             


Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg His Gly  Ser Gly Ser 
    2075                 2080                 2085             


Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly Pro Gly  Leu Gly Glu 
    2090                 2095                 2100             


Ser Ser  Gly Phe Gly His His  Glu Ser Ser Ser Gly  Gln Ser Ser 
    2105                 2110                 2115             


Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly His Ser  Ser Gly Tyr 
    2120                 2125                 2130             


Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser Ser Arg  Gly Glu Arg 
    2135                 2140                 2145             


His Gly  Ser Ser Ser Gly Ser  Ser Ser Arg Tyr Gly  Gln His Gly 
    2150                 2155                 2160             


Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly Arg Gln  Gly Ser Gly 
    2165                 2170                 2175             


Ser Gly  His Ser Pro Ser Arg  Gly Arg His Gly Ser  Gly Ser Gly 
    2180                 2185                 2190             


His Ser  Ser Ser His Gly Gln  His Gly Ser Gly Ser  Gly Arg Ser 
    2195                 2200                 2205             


Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Ser Gly His  Ser Ser Val 
    2210                 2215                 2220             


Phe Gly  Gln His Glu Ser Gly  Ser Gly His Ser Ser  Ala Tyr Ser 
    2225                 2230                 2235             


Gln His  Gly Ser Gly Ser Gly  His Phe Cys Ser Gln  Gly Gln His 
    2240                 2245                 2250             


Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe Asp Gln  Glu Gly Ser 
    2255                 2260                 2265             


Ser Thr  Gly Gln Ser Ser Ser  His Gly Gln His Gly  Ser Gly Ser 
    2270                 2275                 2280             


Ser Gln  Ser Ser Ser Tyr Gly  Gln Gln Gly Ser Gly  Ser Gly Gln 
    2285                 2290                 2295             


Ser Pro  Ser Arg Gly Arg His  Gly Ser Gly Ser Gly  His Ser Ser 
    2300                 2305                 2310             


Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly Trp Ser  Ser Ser Ser 
    2315                 2320                 2325             


Gly Arg  His Gly Ser Gly Ser  Gly Gln Ser Ser Gly  Phe Gly His 
    2330                 2335                 2340             


His Glu  Ser Ser Ser Trp Gln  Ser Ser Gly Tyr Thr  Gln His Gly 
    2345                 2350                 2355             


Ser Gly  Ser Gly His Ser Ser  Ser Tyr Glu Gln His  Gly Ser Arg 
    2360                 2365                 2370             


Ser Gly  Gln Ser Ser Arg Gly  Glu Arg His Gly Ser  Ser Ser Gly 
    2375                 2380                 2385             


Ser Ser  Ser Ser Tyr Gly Gln  His Gly Ser Gly Ser  Arg Gln Ser 
    2390                 2395                 2400             


Leu Gly  His Gly Gln His Gly  Ser Gly Ser Gly Gln  Ser Pro Ser 
    2405                 2410                 2415             


Pro Ser  Arg Gly Arg His Gly  Ser Gly Ser Gly Gln  Ser Ser Ser 
    2420                 2425                 2430             


Tyr Ser  Pro Tyr Gly Ser Gly  Ser Gly Trp Ser Ser  Ser Arg Gly 
    2435                 2440                 2445             


Pro Tyr  Glu Ser Gly Ser Gly  His Ser Ser Gly Leu  Gly His Arg 
    2450                 2455                 2460             


Glu Ser  Arg Ser Gly Gln Ser  Ser Gly Tyr Gly Gln  His Gly Ser 
    2465                 2470                 2475             


Ser Ser  Gly His Ser Ser Thr  His Gly Gln His Gly  Ser Thr Ser 
    2480                 2485                 2490             


Gly Gln  Ser Ser Ser Cys Gly  Gln His Gly Ala Ser  Ser Gly Gln 
    2495                 2500                 2505             


Ser Ser  Ser His Gly Gln His  Gly Ser Gly Ser Ser  Gln Ser Ser 
    2510                 2515                 2520             


Gly Tyr  Gly Arg Gln Gly Ser  Gly Ser Gly Gln Ser  Pro Gly His 
    2525                 2530                 2535             


Gly Gln  Arg Gly Ser Gly Ser  Arg Gln Ser Pro Ser  Tyr Gly Arg 
    2540                 2545                 2550             


His Gly  Ser Gly Ser Gly Arg  Ser Ser Ser Ser Gly  Gln His Gly 
    2555                 2560                 2565             


Ser Gly  Leu Gly Glu Ser Ser  Gly Phe Gly His His  Glu Ser Ser 
    2570                 2575                 2580             


Ser Gly  Gln Ser Ser Ser Tyr  Ser Gln His Gly Ser  Gly Ser Gly 
    2585                 2590                 2595             


His Ser  Ser Gly Tyr Gly Gln  His Gly Ser Arg Ser  Gly Gln Ser 
    2600                 2605                 2610             


Ser Arg  Gly Glu Arg His Gly  Ser Ser Ser Gly Ser  Ser Ser His 
    2615                 2620                 2625             


Tyr Gly  Gln His Gly Ser Gly  Ser Arg Gln Ser Ser  Gly His Gly 
    2630                 2635                 2640             


Arg Gln  Gly Ser Gly Ser Gly  Gln Ser Pro Ser Arg  Gly Arg His 
    2645                 2650                 2655             


Gly Ser  Gly Leu Gly His Ser  Ser Ser His Gly Gln  His Gly Ser 
    2660                 2665                 2670             


Gly Ser  Gly Arg Ser Ser Ser  Arg Gly Pro Tyr Glu  Ser Arg Leu 
    2675                 2680                 2685             


Gly His  Ser Ser Val Phe Gly  Gln His Glu Ser Gly  Ser Gly His 
    2690                 2695                 2700             


Ser Ser  Ala Tyr Ser Gln His  Gly Ser Gly Ser Gly  His Phe Cys 
    2705                 2710                 2715             


Ser Gln  Gly Gln His Gly Ser  Thr Ser Gly Gln Ser  Ser Thr Phe 
    2720                 2725                 2730             


Asp Gln  Glu Gly Ser Ser Thr  Gly Gln Ser Ser Ser  Tyr Gly His 
    2735                 2740                 2745             


Arg Gly  Ser Gly Ser Ser Gln  Ser Ser Gly Tyr Gly  Arg His Gly 
    2750                 2755                 2760             


Ala Gly  Ser Gly Gln Ser Leu  Ser His Gly Arg His  Gly Ser Gly 
    2765                 2770                 2775             


Ser Gly  Gln Ser Ser Ser Tyr  Gly Gln His Gly Ser  Gly Ser Gly 
    2780                 2785                 2790             


Gln Ser  Ser Gly Tyr Ser Gln  His Gly Ser Gly Ser  Gly Gln Asp 
    2795                 2800                 2805             


Gly Tyr  Ser Tyr Cys Lys Gly  Gly Ser Asn His Asp  Gly Gly Ser 
    2810                 2815                 2820             


Ser Gly  Ser Tyr Phe Leu Ser  Phe Pro Ser Ser Thr  Ser Pro Tyr 
    2825                 2830                 2835             


Glu Tyr  Val Gln Glu Gln Arg  Cys Tyr Phe Tyr Gln  
    2840                 2845                 2850 


<210>  5166
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRSP12__Homo_sapiens__NP_005827

<400>  5166

Met Ser Ser Leu Ile Arg Arg Val Ile Ser Thr Ala Lys Ala Pro Gly 
1               5                   10                  15      


Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr 
            20                  25                  30          


Ile Ser Gly Gln Ile Gly Met Asp Pro Ser Ser Gly Gln Leu Val Ser 
        35                  40                  45              


Gly Gly Val Ala Glu Glu Ala Lys Gln Ala Leu Lys Asn Met Gly Glu 
    50                  55                  60                  


Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Thr Thr 
65                  70                  75                  80  


Val Leu Leu Ala Asp Ile Asn Asp Phe Asn Thr Val Asn Glu Ile Tyr 
                85                  90                  95      


Lys Gln Tyr Phe Lys Ser Asn Phe Pro Ala Arg Ala Ala Tyr Gln Val 
            100                 105                 110         


Ala Ala Leu Pro Lys Gly Ser Arg Ile Glu Ile Glu Ala Val Ala Ile 
        115                 120                 125             


Gln Gly Pro Leu Thr Thr Ala Ser Leu 
    130                 135         


<210>  5167
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS1BP3__Homo_sapiens__NP_071905

<400>  5167

Met Gln Ser Pro Ala Val Leu Val Thr Ser Arg Arg Leu Gln Asn Ala 
1               5                   10                  15      


His Thr Gly Leu Asp Leu Thr Val Pro Gln His Gln Glu Val Arg Gly 
            20                  25                  30          


Lys Met Met Ser Gly His Val Glu Tyr Gln Ile Leu Val Val Thr Arg 
        35                  40                  45              


Leu Ala Ala Phe Lys Ser Ala Lys His Arg Pro Glu Asp Val Val Gln 
    50                  55                  60                  


Phe Leu Val Ser Lys Lys Tyr Ser Glu Ile Glu Glu Phe Tyr Gln Lys 
65                  70                  75                  80  


Leu Ser Ser Arg Tyr Ala Ala Ala Ser Leu Pro Pro Leu Pro Arg Lys 
                85                  90                  95      


Val Leu Phe Val Gly Glu Ser Asp Ile Arg Glu Arg Arg Ala Val Phe 
            100                 105                 110         


Asn Glu Ile Leu Arg Cys Val Ser Lys Asp Ala Glu Leu Ala Gly Ser 
        115                 120                 125             


Pro Glu Leu Leu Glu Phe Leu Gly Thr Arg Ser Pro Gly Ala Ala Gly 
    130                 135                 140                 


Leu Thr Ser Arg Asp Ser Ser Val Leu Asp Gly Thr Asp Ser Gln Thr 
145                 150                 155                 160 


Gly Asn Asp Glu Glu Ala Phe Asp Phe Phe Glu Glu Gln Asp Gln Val 
                165                 170                 175     


Ala Glu Glu Gly Pro Pro Val Gln Ser Leu Lys Gly Glu Asp Ala Glu 
            180                 185                 190         


Glu Ser Leu Glu Glu Glu Glu Ala Leu Asp Pro Leu Gly Ile Met Arg 
        195                 200                 205             


Ser Lys Lys Pro Lys Lys His Pro Lys Val Ala Val Lys Ala Lys Pro 
    210                 215                 220                 


Ser Pro Arg Leu Thr Ile Phe Asp Glu Glu Val Asp Pro Asp Glu Gly 
225                 230                 235                 240 


Leu Phe Gly Pro Gly Arg Lys Leu Ser Pro Gln Asp Pro Ser Glu Asp 
                245                 250                 255     


Val Ser Ser Val Asp Pro Leu Lys Leu Phe Asp Asp Pro Asp Leu Gly 
            260                 265                 270         


Gly Ala Ile Pro Leu Gly Asp Ser Leu Leu Leu Pro Ala Ala Cys Glu 
        275                 280                 285             


Ser Gly Gly Pro Thr Pro Ser Leu Ser His Arg Asp Ala Ser Lys Glu 
    290                 295                 300                 


Leu Phe Arg Val Glu Glu Asp Leu Asp Gln Ile Leu Asn Leu Gly Ala 
305                 310                 315                 320 


Glu Pro Lys Pro Lys Pro Gln Leu Lys Pro Lys Pro Pro Val Ala Ala 
                325                 330                 335     


Lys Pro Val Ile Pro Arg Lys Pro Ala Val Pro Pro Lys Ala Gly Pro 
            340                 345                 350         


Ala Glu Ala Val Ala Gly Gln Gln Lys Pro Gln Glu Gln Ile Gln Ala 
        355                 360                 365             


Met Asp Glu Met Asp Ile Leu Gln Tyr Ile Gln Asp His Asp Thr Pro 
    370                 375                 380                 


Ala Gln Ala Ala Pro Ser Leu Phe 
385                 390         


<210>  5168
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3ST1__Homo_sapiens__NP_005105

<400>  5168

Met Ala Ala Leu Leu Leu Gly Ala Val Leu Leu Val Ala Gln Pro Gln 
1               5                   10                  15      


Leu Val Pro Ser Arg Pro Ala Glu Leu Gly Gln Gln Glu Leu Leu Arg 
            20                  25                  30          


Lys Ala Gly Thr Leu Gln Asp Asp Val Arg Asp Gly Val Ala Pro Asn 
        35                  40                  45              


Gly Ser Ala Gln Gln Leu Pro Gln Thr Ile Ile Ile Gly Val Arg Lys 
    50                  55                  60                  


Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Ser Leu His Pro Asp Val 
65                  70                  75                  80  


Ala Ala Ala Glu Asn Glu Val His Phe Phe Asp Trp Glu Glu His Tyr 
                85                  90                  95      


Ser His Gly Leu Gly Trp Tyr Leu Ser Gln Met Pro Phe Ser Trp Pro 
            100                 105                 110         


His Gln Leu Thr Val Glu Lys Thr Pro Ala Tyr Phe Thr Ser Pro Lys 
        115                 120                 125             


Val Pro Glu Arg Val Tyr Ser Met Asn Pro Ser Ile Arg Leu Leu Leu 
    130                 135                 140                 


Ile Leu Arg Asp Pro Ser Glu Arg Val Leu Ser Asp Tyr Thr Gln Val 
145                 150                 155                 160 


Phe Tyr Asn His Met Gln Lys His Lys Pro Tyr Pro Ser Ile Glu Glu 
                165                 170                 175     


Phe Leu Val Arg Asp Gly Arg Leu Asn Val Asp Tyr Lys Ala Leu Asn 
            180                 185                 190         


Arg Ser Leu Tyr His Val His Met Gln Asn Trp Leu Arg Phe Phe Pro 
        195                 200                 205             


Leu Arg His Ile His Ile Val Asp Gly Asp Arg Leu Ile Arg Asp Pro 
    210                 215                 220                 


Phe Pro Glu Ile Gln Lys Val Glu Arg Phe Leu Lys Leu Ser Pro Gln 
225                 230                 235                 240 


Ile Asn Ala Ser Asn Phe Tyr Phe Asn Lys Thr Lys Gly Phe Tyr Cys 
                245                 250                 255     


Leu Arg Asp Ser Gly Arg Asp Arg Cys Leu His Glu Ser Lys Gly Arg 
            260                 265                 270         


Ala His Pro Gln Val Asp Pro Lys Leu Leu Asn Lys Leu His Glu Tyr 
        275                 280                 285             


Phe His Glu Pro Asn Lys Lys Phe Phe Glu Leu Val Gly Arg Thr Phe 
    290                 295                 300                 


Asp Trp His 
305         


<210>  5169
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3ST2__Homo_sapiens__NP_006034

<400>  5169

Met Ala Tyr Arg Val Leu Gly Arg Ala Gly Pro Pro Gln Pro Arg Arg 
1               5                   10                  15      


Ala Arg Arg Leu Leu Phe Ala Phe Thr Leu Ser Leu Ser Cys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Ser Phe Leu Cys Cys Cys Asp Asp Leu Gly Arg Ser Arg 
        35                  40                  45              


Leu Leu Gly Ala Pro Arg Cys Leu Arg Gly Pro Ser Ala Gly Gly Gln 
    50                  55                  60                  


Lys Leu Leu Gln Lys Ser Arg Pro Cys Asp Pro Ser Gly Pro Thr Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Ala Pro Ser Ala Pro Ala Ala Ala Val Pro Ala Pro 
                85                  90                  95      


Arg Leu Ser Gly Ser Asn His Ser Gly Ser Pro Lys Leu Gly Thr Lys 
            100                 105                 110         


Arg Leu Pro Gln Ala Leu Ile Val Gly Val Lys Lys Gly Gly Thr Arg 
        115                 120                 125             


Ala Val Leu Glu Phe Ile Arg Val His Pro Asp Val Arg Ala Leu Gly 
    130                 135                 140                 


Thr Glu Pro His Phe Phe Asp Arg Asn Tyr Gly Arg Gly Leu Asp Trp 
145                 150                 155                 160 


Tyr Arg Ser Leu Met Pro Arg Thr Leu Glu Ser Gln Ile Thr Leu Glu 
                165                 170                 175     


Lys Thr Pro Ser Tyr Phe Val Thr Gln Glu Ala Pro Arg Arg Ile Phe 
            180                 185                 190         


Asn Met Ser Arg Asp Thr Lys Leu Ile Val Val Val Arg Asn Pro Val 
        195                 200                 205             


Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr Leu Ser Lys Lys Pro Asp 
    210                 215                 220                 


Ile Pro Thr Phe Glu Gly Leu Ser Phe Arg Asn Arg Thr Leu Gly Leu 
225                 230                 235                 240 


Val Asp Val Ser Trp Asn Ala Ile Arg Ile Gly Met Tyr Val Leu His 
                245                 250                 255     


Leu Glu Ser Trp Leu Gln Tyr Phe Pro Leu Ala Gln Ile His Phe Val 
            260                 265                 270         


Ser Gly Glu Arg Leu Ile Thr Asp Pro Ala Gly Glu Met Gly Arg Val 
        275                 280                 285             


Gln Asp Phe Leu Gly Ile Lys Arg Phe Ile Thr Asp Lys His Phe Tyr 
    290                 295                 300                 


Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu Lys Lys Thr Glu Ser Ser 
305                 310                 315                 320 


Leu Leu Pro Arg Cys Leu Gly Lys Ser Lys Gly Arg Thr His Val Gln 
                325                 330                 335     


Ile Asp Pro Glu Val Ile Asp Gln Leu Arg Glu Phe Tyr Arg Pro Tyr 
            340                 345                 350         


Asn Ile Lys Phe Tyr Glu Thr Val Gly Gln Asp Phe Arg Trp Glu 
        355                 360                 365         


<210>  5170
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3ST3A1__Homo_sapiens__NP_006033

<400>  5170

Met Ala Pro Pro Gly Pro Ala Ser Ala Leu Ser Thr Ser Ala Glu Pro 
1               5                   10                  15      


Leu Ser Arg Ser Ile Phe Arg Lys Phe Leu Leu Met Leu Cys Ser Leu 
            20                  25                  30          


Leu Thr Ser Leu Tyr Val Phe Tyr Cys Leu Ala Glu Arg Cys Gln Thr 
        35                  40                  45              


Leu Ser Gly Pro Val Val Gly Leu Ser Gly Gly Gly Glu Glu Ala Gly 
    50                  55                  60                  


Ala Pro Gly Gly Gly Val Leu Ala Gly Gly Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Trp Pro Ala Ala Ala Gln Arg Lys Arg Leu Leu Gln Leu Pro Gln Trp 
                85                  90                  95      


Arg Arg Arg Arg Pro Pro Ala Pro Arg Asp Asp Gly Glu Glu Ala Ala 
            100                 105                 110         


Trp Glu Glu Glu Ser Pro Gly Leu Ser Gly Gly Pro Gly Gly Ser Gly 
        115                 120                 125             


Ala Gly Ser Thr Val Ala Glu Ala Pro Pro Gly Thr Leu Ala Leu Leu 
    130                 135                 140                 


Leu Asp Glu Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile Ile Gly Val 
145                 150                 155                 160 


Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Val His Pro 
                165                 170                 175     


Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp Arg Ser Tyr 
            180                 185                 190         


Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg Thr Leu Asp 
        195                 200                 205             


Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg Glu 
    210                 215                 220                 


Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys Leu Ile Val 
225                 230                 235                 240 


Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr 
                245                 250                 255     


Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu Ser Leu Thr Phe Lys 
            260                 265                 270         


Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala Ile Gln Ile 
        275                 280                 285             


Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu Arg His Phe Pro Ile 
    290                 295                 300                 


Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu Ile Ser Asp Pro Ala 
305                 310                 315                 320 


Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Ile Ile 
                325                 330                 335     


Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu 
            340                 345                 350         


Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys Leu Gly Lys Thr Lys 
        355                 360                 365             


Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val Val Arg Arg Leu Arg 
    370                 375                 380                 


Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr Gln Met Thr Gly His 
385                 390                 395                 400 


Asp Phe Gly Trp Asp Gly 
                405     


<210>  5171
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3ST3B1__Homo_sapiens__NP_006032

<400>  5171

Met Gly Gln Arg Leu Ser Gly Gly Arg Ser Cys Leu Asp Val Pro Gly 
1               5                   10                  15      


Arg Leu Leu Pro Gln Pro Pro Pro Pro Pro Pro Pro Val Arg Arg Lys 
            20                  25                  30          


Leu Ala Leu Leu Phe Ala Met Leu Cys Val Trp Leu Tyr Met Phe Leu 
        35                  40                  45              


Tyr Ser Cys Ala Gly Ser Cys Ala Ala Ala Pro Gly Leu Leu Leu Leu 
    50                  55                  60                  


Gly Ser Gly Ser Arg Ala Ala His Asp Pro Pro Ala Leu Ala Thr Ala 
65                  70                  75                  80  


Pro Asp Gly Thr Pro Pro Arg Leu Pro Phe Arg Ala Pro Pro Ala Thr 
                85                  90                  95      


Pro Leu Ala Ser Gly Lys Glu Met Ala Glu Gly Ala Ala Ser Pro Glu 
            100                 105                 110         


Glu Gln Ser Pro Glu Val Pro Asp Ser Pro Ser Pro Ile Ser Ser Phe 
        115                 120                 125             


Phe Ser Gly Ser Gly Ser Lys Gln Leu Pro Gln Ala Ile Ile Ile Gly 
    130                 135                 140                 


Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Val His 
145                 150                 155                 160 


Pro Asp Val Arg Ala Val Gly Ala Glu Pro His Phe Phe Asp Arg Ser 
                165                 170                 175     


Tyr Asp Lys Gly Leu Ala Trp Tyr Arg Asp Leu Met Pro Arg Thr Leu 
            180                 185                 190         


Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Arg 
        195                 200                 205             


Glu Ala Pro Ala Arg Ile Ser Ala Met Ser Lys Asp Thr Lys Leu Ile 
    210                 215                 220                 


Val Val Val Arg Asp Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln 
225                 230                 235                 240 


Thr Leu Ser Lys Arg Pro Asp Ile Pro Thr Phe Glu Ser Leu Thr Phe 
                245                 250                 255     


Lys Asn Arg Thr Ala Gly Leu Ile Asp Thr Ser Trp Ser Ala Ile Gln 
            260                 265                 270         


Ile Gly Ile Tyr Ala Lys His Leu Glu His Trp Leu Arg His Phe Pro 
        275                 280                 285             


Ile Arg Gln Met Leu Phe Val Ser Gly Glu Arg Leu Ile Ser Asp Pro 
    290                 295                 300                 


Ala Gly Glu Leu Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Ile 
305                 310                 315                 320 


Ile Thr Asp Lys His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys 
                325                 330                 335     


Leu Lys Lys Ala Glu Gly Ser Ser Arg Pro His Cys Leu Gly Lys Thr 
            340                 345                 350         


Lys Gly Arg Thr His Pro Glu Ile Asp Arg Glu Val Val Arg Arg Leu 
        355                 360                 365             


Arg Glu Phe Tyr Arg Pro Phe Asn Leu Lys Phe Tyr Gln Met Thr Gly 
    370                 375                 380                 


His Asp Phe Gly Trp Asp 
385                 390 


<210>  5172
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3ST4__Homo_sapiens__NP_006031

<400>  5172

Met Ala Arg Trp Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Leu Ala Ala Pro Pro Pro Pro Gly Ala Ser Ala Lys Gly Pro Pro Ala 
            20                  25                  30          


Arg Lys Leu Leu Phe Met Cys Thr Leu Ser Leu Ser Val Thr Tyr Leu 
        35                  40                  45              


Cys Tyr Ser Leu Leu Gly Gly Ser Gly Ser Leu Gln Phe Pro Leu Ala 
    50                  55                  60                  


Leu Gln Glu Ser Pro Gly Ala Ala Ala Glu Pro Pro Pro Ser Pro Pro 
65                  70                  75                  80  


Pro Pro Ser Leu Leu Pro Thr Pro Val Arg Leu Gly Ala Pro Ser Gln 
                85                  90                  95      


Pro Pro Ala Pro Pro Pro Leu Asp Asn Ala Ser His Gly Glu Pro Pro 
            100                 105                 110         


Glu Pro Pro Glu Gln Pro Ala Ala Pro Gly Thr Asp Gly Trp Gly Leu 
        115                 120                 125             


Pro Ser Gly Gly Gly Gly Ala Gln Asp Ala Trp Leu Arg Thr Pro Leu 
    130                 135                 140                 


Ala Pro Ser Glu Met Ile Thr Ala Gln Ser Ala Leu Pro Glu Arg Glu 
145                 150                 155                 160 


Ala Gln Glu Ser Ser Thr Thr Asp Glu Asp Leu Ala Gly Arg Arg Ala 
                165                 170                 175     


Ala Asn Gly Ser Ser Glu Arg Gly Gly Ala Val Ser Thr Pro Asp Tyr 
            180                 185                 190         


Gly Glu Lys Lys Leu Pro Gln Ala Leu Ile Ile Gly Val Lys Lys Gly 
        195                 200                 205             


Gly Thr Arg Ala Leu Leu Glu Ala Ile Arg Val His Pro Asp Val Arg 
    210                 215                 220                 


Ala Val Gly Val Glu Pro His Phe Phe Asp Arg Asn Tyr Glu Lys Gly 
225                 230                 235                 240 


Leu Glu Trp Tyr Arg Asn Val Met Pro Lys Thr Leu Asp Gly Gln Ile 
                245                 250                 255     


Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr Asn Glu Ala Pro Lys 
            260                 265                 270         


Arg Ile His Ser Met Ala Lys Asp Ile Lys Leu Ile Val Val Val Arg 
        275                 280                 285             


Asn Pro Val Thr Arg Ala Ile Ser Asp Tyr Thr Gln Thr Leu Ser Lys 
    290                 295                 300                 


Lys Pro Glu Ile Pro Thr Phe Glu Val Leu Ala Phe Lys Asn Arg Thr 
305                 310                 315                 320 


Leu Gly Leu Ile Asp Ala Ser Trp Ser Ala Ile Arg Ile Gly Ile Tyr 
                325                 330                 335     


Ala Leu His Leu Glu Asn Trp Leu Gln Tyr Phe Pro Leu Ser Gln Ile 
            340                 345                 350         


Leu Phe Val Ser Gly Glu Arg Leu Ile Val Asp Pro Ala Gly Glu Met 
        355                 360                 365             


Ala Lys Val Gln Asp Phe Leu Gly Leu Lys Arg Val Val Thr Glu Lys 
    370                 375                 380                 


His Phe Tyr Phe Asn Lys Thr Lys Gly Phe Pro Cys Leu Lys Lys Pro 
385                 390                 395                 400 


Glu Asp Ser Ser Ala Pro Arg Cys Leu Gly Lys Ser Lys Gly Arg Thr 
                405                 410                 415     


His Pro Arg Ile Asp Pro Asp Val Ile His Arg Leu Arg Lys Phe Tyr 
            420                 425                 430         


Lys Pro Phe Asn Leu Met Phe Tyr Gln Met Thr Gly Gln Asp Phe Gln 
        435                 440                 445             


Trp Glu Gln Glu Glu Gly Asp Lys 
    450                 455     


<210>  5173
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3ST5__Homo_sapiens__NP_705840

<400>  5173

Met Leu Phe Lys Gln Gln Ala Trp Leu Arg Gln Lys Leu Leu Val Leu 
1               5                   10                  15      


Gly Ser Leu Ala Val Gly Ser Leu Leu Tyr Leu Val Ala Arg Val Gly 
            20                  25                  30          


Ser Leu Asp Arg Leu Gln Pro Ile Cys Pro Ile Glu Gly Arg Leu Gly 
        35                  40                  45              


Gly Ala Arg Thr Gln Ala Glu Phe Pro Leu Arg Ala Leu Gln Phe Lys 
    50                  55                  60                  


Arg Gly Leu Leu His Glu Phe Arg Lys Gly Asn Ala Ser Lys Glu Gln 
65                  70                  75                  80  


Val Arg Leu His Asp Leu Val Gln Gln Leu Pro Lys Ala Ile Ile Ile 
                85                  90                  95      


Gly Val Arg Lys Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Asn Leu 
            100                 105                 110         


His Pro Ala Val Val Lys Ala Ser Gln Glu Ile His Phe Phe Asp Asn 
        115                 120                 125             


Asp Glu Asn Tyr Gly Lys Gly Ile Glu Trp Tyr Arg Lys Lys Met Pro 
    130                 135                 140                 


Phe Ser Tyr Pro Gln Gln Ile Thr Ile Glu Lys Ser Pro Ala Tyr Phe 
145                 150                 155                 160 


Ile Thr Glu Glu Val Pro Glu Arg Ile Tyr Lys Met Asn Ser Ser Ile 
                165                 170                 175     


Lys Leu Leu Ile Ile Val Arg Glu Pro Thr Thr Arg Ala Ile Ser Asp 
            180                 185                 190         


Tyr Thr Gln Val Leu Glu Gly Lys Glu Arg Lys Asn Lys Thr Tyr Tyr 
        195                 200                 205             


Lys Phe Glu Lys Leu Ala Ile Asp Pro Asn Thr Cys Glu Val Asn Thr 
    210                 215                 220                 


Lys Tyr Lys Ala Val Arg Thr Ser Ile Tyr Thr Lys His Leu Glu Arg 
225                 230                 235                 240 


Trp Leu Lys Tyr Phe Pro Ile Glu Gln Phe His Val Val Asp Gly Asp 
                245                 250                 255     


Arg Leu Ile Thr Glu Pro Leu Pro Glu Leu Gln Leu Val Glu Lys Phe 
            260                 265                 270         


Leu Asn Leu Pro Pro Arg Ile Ser Gln Tyr Asn Leu Tyr Phe Asn Ala 
        275                 280                 285             


Thr Arg Gly Phe Tyr Cys Leu Arg Phe Asn Ile Ile Phe Asn Lys Cys 
    290                 295                 300                 


Leu Ala Gly Ser Lys Gly Arg Ile His Pro Glu Val Asp Pro Ser Val 
305                 310                 315                 320 


Ile Thr Lys Leu Arg Lys Phe Phe His Pro Phe Asn Gln Lys Phe Tyr 
                325                 330                 335     


Gln Ile Thr Gly Arg Thr Leu Asn Trp Pro 
            340                 345     


<210>  5174
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS3ST6__Homo_sapiens__NP_001009606

<400>  5174

Met Ala Gly Ser Gly Gly Leu Gly Gly Gly Ala Gly Gly Gly Gln Gly 
1               5                   10                  15      


Ala Gly Ala Gly Gln Gly Ala Ala Leu Arg Ala Ser Arg Ala Pro Met 
            20                  25                  30          


Leu Leu Val Ala Leu Val Leu Gly Ala Tyr Cys Leu Cys Ala Leu Pro 
        35                  40                  45              


Gly Arg Cys Pro Pro Ala Ala Arg Ala Pro Ala Pro Ala Pro Ala Pro 
    50                  55                  60                  


Ser Glu Pro Ser Ser Ser Val His Arg Pro Gly Ala Pro Gly Leu Pro 
65                  70                  75                  80  


Leu Ala Ser Gly Pro Gly Arg Arg Arg Phe Pro Gln Ala Leu Ile Val 
                85                  90                  95      


Gly Val Lys Lys Gly Gly Thr Arg Ala Leu Leu Glu Phe Leu Arg Leu 
            100                 105                 110         


His Pro Asp Val Arg Ala Leu Gly Ser Glu Pro His Phe Phe Asp Arg 
        115                 120                 125             


Cys Tyr Glu Arg Gly Leu Ala Trp Tyr Arg Ser Leu Met Pro Arg Thr 
    130                 135                 140                 


Leu Asp Gly Gln Ile Thr Met Glu Lys Thr Pro Ser Tyr Phe Val Thr 
145                 150                 155                 160 


Arg Glu Ala Pro Arg Arg Ile His Ala Met Ser Pro Asp Thr Lys Leu 
                165                 170                 175     


Ile Val Val Val Arg Asn Pro Val Thr Arg Ala Ile Ser Asp Tyr Ala 
            180                 185                 190         


Gln Thr Leu Ser Lys Thr Pro Gly Leu Pro Ser Phe Arg Ala Leu Ala 
        195                 200                 205             


Phe Arg His Gly Leu Gly Pro Val Asp Thr Ala Trp Ser Ala Val Arg 
    210                 215                 220                 


Ile Gly Leu Tyr Ala Gln His Leu Asp His Trp Leu Arg Tyr Phe Pro 
225                 230                 235                 240 


Leu Ser His Phe Leu Phe Val Ser Gly Glu Arg Leu Val Ser Asp Pro 
                245                 250                 255     


Ala Gly Glu Val Gly Arg Val Gln Asp Phe Leu Gly Leu Lys Arg Val 
            260                 265                 270         


Val Thr Asp Lys His Phe Tyr Phe Asn Ala Thr Lys Gly Phe Pro Cys 
        275                 280                 285             


Leu Lys Lys Ala Gln Gly Gly Ser Arg Pro Arg Cys Leu Gly Lys Ser 
    290                 295                 300                 


Lys Gly Arg Pro His Pro Arg Val Pro Gln Ala Leu Val Arg Arg Leu 
305                 310                 315                 320 


Gln Glu Phe Tyr Arg Pro Phe Asn Arg Arg Phe Tyr Gln Met Thr Gly 
                325                 330                 335     


Gln Asp Phe Gly Trp Gly 
            340         


<210>  5175
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS6ST1__Homo_sapiens__NP_004798

<400>  5175

Met Arg Arg Arg Arg Ala Gly Gly Arg Thr Met Val Glu Arg Ala Ser 
1               5                   10                  15      


Lys Phe Val Leu Val Val Ala Gly Ser Val Cys Phe Met Leu Ile Leu 
            20                  25                  30          


Tyr Gln Tyr Ala Gly Pro Gly Leu Ser Leu Gly Ala Pro Gly Gly Arg 
        35                  40                  45              


Ala Pro Pro Asp Asp Leu Asp Leu Phe Pro Thr Pro Asp Pro His Tyr 
    50                  55                  60                  


Glu Lys Lys Tyr Tyr Phe Pro Val Arg Glu Leu Glu Arg Ser Leu Arg 
65                  70                  75                  80  


Phe Asp Met Lys Gly Asp Asp Val Ile Val Phe Leu His Ile Gln Lys 
                85                  90                  95      


Thr Gly Gly Thr Thr Phe Gly Arg His Leu Val Gln Asn Val Arg Leu 
            100                 105                 110         


Glu Val Pro Cys Asp Cys Arg Pro Gly Gln Lys Lys Cys Thr Cys Tyr 
        115                 120                 125             


Arg Pro Asn Arg Arg Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly 
    130                 135                 140                 


Trp Ser Cys Gly Leu His Ala Asp Trp Thr Glu Leu Thr Asn Cys Val 
145                 150                 155                 160 


Pro Gly Val Leu Asp Arg Arg Asp Ser Ala Ala Leu Arg Thr Pro Arg 
                165                 170                 175     


Lys Phe Tyr Tyr Ile Thr Leu Leu Arg Asp Pro Val Ser Arg Tyr Leu 
            180                 185                 190         


Ser Glu Trp Arg His Val Gln Arg Gly Ala Thr Trp Lys Thr Ser Leu 
        195                 200                 205             


His Met Cys Asp Gly Arg Thr Pro Thr Pro Glu Glu Leu Pro Pro Cys 
    210                 215                 220                 


Tyr Glu Gly Thr Asp Trp Ser Gly Cys Thr Leu Gln Glu Phe Met Asp 
225                 230                 235                 240 


Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln Val Arg Met Leu Ala Asp 
                245                 250                 255     


Leu Ser Leu Val Gly Cys Tyr Asn Leu Ser Phe Ile Pro Glu Gly Lys 
            260                 265                 270         


Arg Ala Gln Leu Leu Leu Glu Ser Ala Lys Lys Asn Leu Arg Gly Met 
        275                 280                 285             


Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg Lys Thr Gln Tyr Leu Phe 
    290                 295                 300                 


Glu Arg Thr Phe Asn Leu Lys Phe Ile Arg Pro Phe Met Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Arg Ala Gly Gly Val Glu Val Asp Glu Asp Thr Ile Arg Arg 
                325                 330                 335     


Ile Glu Glu Leu Asn Asp Leu Asp Met Gln Leu Tyr Asp Tyr Ala Lys 
            340                 345                 350         


Asp Leu Phe Gln Gln Arg Tyr Gln Tyr Lys Arg Gln Leu Glu Arg Arg 
        355                 360                 365             


Glu Gln Arg Leu Arg Ser Arg Glu Glu Arg Leu Leu His Arg Ala Lys 
    370                 375                 380                 


Glu Ala Leu Pro Arg Glu Asp Ala Asp Glu Pro Gly Arg Val Pro Thr 
385                 390                 395                 400 


Glu Asp Tyr Met Ser His Ile Ile Glu Lys Trp 
                405                 410     


<210>  5176
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS6ST2__Homo_sapiens__NP_001070656

<400>  5176

Met Ala Leu Pro Ala Cys Ala Val Arg Glu Phe Glu Pro Pro Arg Gln 
1               5                   10                  15      


Pro Glu Arg Gly Ala Pro Val Arg Thr Thr Cys Pro Arg Arg His Ser 
            20                  25                  30          


Arg Val Glu Ala Glu Leu Ala Ala Ser Arg Pro Gly Ser Val Ala Ala 
        35                  40                  45              


Ser Val Arg Ala Gly Pro Pro Arg Gly Val Ser His Gly Phe His Thr 
    50                  55                  60                  


Arg Pro Leu Leu Asp Lys Pro Arg Lys Ala Ser Ser Ser Leu Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Ala Pro Leu Phe Ala Leu Leu Ser Arg Gly Arg Arg Arg 
                85                  90                  95      


Arg Met His Val Leu Arg Arg Arg Trp Asp Leu Gly Ser Leu Cys Arg 
            100                 105                 110         


Ala Leu Leu Thr Arg Gly Leu Ala Ala Leu Gly His Ser Leu Lys His 
        115                 120                 125             


Val Leu Gly Ala Ile Phe Ser Lys Ile Phe Gly Pro Met Ala Ser Val 
    130                 135                 140                 


Gly Asn Met Asp Glu Lys Ser Asn Lys Leu Leu Leu Ala Leu Val Met 
145                 150                 155                 160 


Leu Phe Leu Phe Ala Val Ile Val Leu Gln Tyr Val Cys Pro Gly Thr 
                165                 170                 175     


Glu Cys Gln Leu Leu Arg Leu Gln Ala Phe Ser Ser Pro Val Pro Asp 
            180                 185                 190         


Pro Tyr Arg Ser Glu Asp Glu Ser Ser Ala Arg Phe Val Pro Arg Tyr 
        195                 200                 205             


Asn Phe Thr Arg Gly Asp Leu Leu Arg Lys Val Asp Phe Asp Ile Lys 
    210                 215                 220                 


Gly Asp Asp Leu Ile Val Phe Leu His Ile Gln Lys Thr Gly Gly Thr 
225                 230                 235                 240 


Thr Phe Gly Arg His Leu Val Arg Asn Ile Gln Leu Glu Gln Pro Cys 
                245                 250                 255     


Glu Cys Arg Val Gly Gln Lys Lys Cys Thr Cys His Arg Pro Gly Lys 
            260                 265                 270         


Arg Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly 
        275                 280                 285             


Leu His Ala Asp Trp Thr Glu Leu Thr Ser Cys Val Pro Ser Val Val 
    290                 295                 300                 


Asp Gly Lys Arg Asp Ala Arg Leu Arg Pro Ser Arg Trp Arg Ile Phe 
305                 310                 315                 320 


Gln Ile Leu Asp Ala Ala Ser Lys Asp Lys Arg Gly Ser Pro Asn Thr 
                325                 330                 335     


Asn Ala Gly Ala Asn Ser Pro Ser Ser Thr Lys Thr Arg Asn Thr Ser 
            340                 345                 350         


Lys Ser Gly Lys Asn Phe His Tyr Ile Thr Ile Leu Arg Asp Pro Val 
        355                 360                 365             


Ser Arg Tyr Leu Ser Glu Trp Arg His Val Gln Arg Gly Ala Thr Trp 
    370                 375                 380                 


Lys Ala Ser Leu His Val Cys Asp Gly Arg Pro Pro Thr Ser Glu Glu 
385                 390                 395                 400 


Leu Pro Ser Cys Tyr Thr Gly Asp Asp Trp Ser Gly Cys Pro Leu Lys 
                405                 410                 415     


Glu Phe Met Asp Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln Val Arg 
            420                 425                 430         


Met Leu Ser Asp Leu Thr Leu Val Gly Cys Tyr Asn Leu Ser Val Met 
        435                 440                 445             


Pro Glu Lys Gln Arg Asn Lys Val Leu Leu Glu Ser Ala Lys Ser Asn 
    450                 455                 460                 


Leu Lys His Met Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg Lys Thr 
465                 470                 475                 480 


Gln Tyr Leu Phe Glu Lys Thr Phe Asn Met Asn Phe Ile Ser Pro Phe 
                485                 490                 495     


Thr Gln Tyr Asn Thr Thr Arg Ala Ser Ser Val Glu Ile Asn Glu Glu 
            500                 505                 510         


Ile Gln Lys Arg Ile Glu Gly Leu Asn Phe Leu Asp Met Glu Leu Tyr 
        515                 520                 525             


Ser Tyr Ala Lys Asp Leu Phe Leu Gln Arg Tyr Gln Phe Met Arg Gln 
    530                 535                 540                 


Lys Glu His Gln Glu Ala Arg Arg Lys Arg Gln Glu Gln Arg Lys Phe 
545                 550                 555                 560 


Leu Lys Gly Arg Leu Leu Gln Thr His Phe Gln Ser Gln Gly Gln Gly 
                565                 570                 575     


Gln Ser Gln Asn Pro Asn Gln Asn Gln Ser Gln Asn Pro Asn Pro Asn 
            580                 585                 590         


Ala Asn Gln Asn Leu Thr Gln Asn Leu Met Gln Asn Leu Thr Gln Ser 
        595                 600                 605             


Leu Ser Gln Lys Glu Asn Arg Glu Ser Pro Lys Gln Asn Ser Gly Lys 
    610                 615                 620                 


Glu Gln Asn Asp Asn Thr Ser Asn Gly Thr Asn Asp Tyr Ile Gly Ser 
625                 630                 635                 640 


Val Glu Lys Trp Arg 
                645 


<210>  5177
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HS6ST3__Homo_sapiens__NP_703157

<400>  5177

Met Asp Glu Arg Phe Asn Lys Trp Leu Leu Thr Pro Val Leu Thr Leu 
1               5                   10                  15      


Leu Phe Val Val Ile Met Tyr Gln Tyr Val Ser Pro Ser Cys Thr Ser 
            20                  25                  30          


Ser Cys Thr Asn Phe Gly Glu Gln Pro Arg Ala Gly Glu Ala Gly Pro 
        35                  40                  45              


Pro Ala Val Pro Gly Pro Ala Arg Arg Ala Gln Ala Pro Pro Glu Glu 
    50                  55                  60                  


Trp Glu Arg Arg Pro Gln Leu Pro Pro Pro Pro Arg Gly Pro Pro Glu 
65                  70                  75                  80  


Gly Pro Arg Gly Ala Ala Ala Pro Glu Glu Glu Asp Glu Glu Pro Gly 
                85                  90                  95      


Asp Pro Arg Glu Gly Glu Glu Glu Glu Glu Glu Asp Glu Pro Asp Pro 
            100                 105                 110         


Glu Ala Pro Glu Asn Gly Ser Leu Pro Arg Phe Val Pro Arg Phe Asn 
        115                 120                 125             


Phe Ser Leu Lys Asp Leu Thr Arg Phe Val Asp Phe Asn Ile Lys Gly 
    130                 135                 140                 


Arg Asp Val Ile Val Phe Leu His Ile Gln Lys Thr Gly Gly Thr Thr 
145                 150                 155                 160 


Phe Gly Arg His Leu Val Lys Asn Ile Arg Leu Glu Gln Pro Cys Ser 
                165                 170                 175     


Cys Lys Ala Gly Gln Lys Lys Cys Thr Cys His Arg Pro Gly Lys Lys 
            180                 185                 190         


Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly Trp Ser Cys Gly Leu 
        195                 200                 205             


His Ala Asp Trp Thr Glu Leu Thr Asn Cys Val Pro Ala Ile Met Glu 
    210                 215                 220                 


Lys Lys Asp Cys Pro Arg Asn His Ser His Thr Arg Asn Phe Tyr Tyr 
225                 230                 235                 240 


Ile Thr Met Leu Arg Asp Pro Val Ser Arg Tyr Leu Ser Glu Trp Lys 
                245                 250                 255     


His Val Gln Arg Gly Ala Thr Trp Lys Thr Ser Leu His Met Cys Asp 
            260                 265                 270         


Gly Arg Ser Pro Thr Pro Asp Glu Leu Pro Thr Cys Tyr Pro Gly Asp 
        275                 280                 285             


Asp Trp Ser Gly Val Ser Leu Arg Glu Phe Met Asp Cys Thr Tyr Asn 
    290                 295                 300                 


Leu Ala Asn Asn Arg Gln Val Arg Met Leu Ala Asp Leu Ser Leu Val 
305                 310                 315                 320 


Gly Cys Tyr Asn Leu Thr Phe Met Asn Glu Ser Glu Arg Asn Thr Ile 
                325                 330                 335     


Leu Leu Gln Ser Ala Lys Asn Asn Leu Lys Asn Met Ala Phe Phe Gly 
            340                 345                 350         


Leu Thr Glu Phe Gln Arg Lys Thr Gln Phe Leu Phe Glu Arg Thr Phe 
        355                 360                 365             


Asn Leu Lys Phe Ile Ser Pro Phe Thr Gln Phe Asn Ile Thr Arg Ala 
    370                 375                 380                 


Ser Asn Val Glu Ile Asn Glu Gly Ala Arg Gln Arg Ile Glu Asp Leu 
385                 390                 395                 400 


Asn Phe Leu Asp Met Gln Leu Tyr Glu Tyr Ala Lys Asp Leu Phe Gln 
                405                 410                 415     


Gln Arg Tyr His His Thr Lys Gln Leu Glu His Gln Arg Asp Arg Gln 
            420                 425                 430         


Lys Arg Arg Glu Glu Arg Arg Leu Gln Arg Glu His Arg Asp His Gln 
        435                 440                 445             


Trp Pro Lys Glu Asp Gly Ala Ala Glu Gly Thr Val Thr Glu Asp Tyr 
    450                 455                 460                 


Asn Ser Gln Val Val Arg Trp 
465                 470     


<210>  5178
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSBP1__Homo_sapiens__NP_001528

<400>  5178

Met Ala Glu Thr Asp Pro Lys Thr Val Gln Asp Leu Thr Ser Val Val 
1               5                   10                  15      


Gln Thr Leu Leu Gln Gln Met Gln Asp Lys Phe Gln Thr Met Ser Asp 
            20                  25                  30          


Gln Ile Ile Gly Arg Ile Asp Asp Met Ser Ser Arg Ile Asp Asp Leu 
        35                  40                  45              


Glu Lys Asn Ile Ala Asp Leu Met Thr Gln Ala Gly Val Glu Glu Leu 
    50                  55                  60                  


Glu Ser Glu Asn Lys Ile Pro Ala Thr Gln Lys Ser 
65                  70                  75      


<210>  5179
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD11B1__Homo_sapiens__NP_001193670

<400>  5179

Met Ala Phe Met Lys Lys Tyr Leu Leu Pro Ile Leu Gly Leu Phe Met 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Ala Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ala Lys Met Gly Ala His Val Val Val Thr 
    50                  55                  60                  


Ala Arg Ser Lys Glu Thr Leu Gln Lys Val Val Ser His Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Val Ala Gln Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Asn Thr Ser Leu Asn Leu 
        115                 120                 125             


Phe His Asp Asp Ile His His Val Arg Lys Ser Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Leu Thr Val Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Val Val Val Ser Ser Leu Ala Gly Lys Val Ala 
                165                 170                 175     


Tyr Pro Met Val Ala Ala Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Ser Ile Arg Lys Glu Tyr Ser Val Ser Arg Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Ala Val Ser Gly Ile Val His Met Gln Ala Ala Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Gly Ala Leu Arg Gln Glu Glu Val 
                245                 250                 255     


Tyr Tyr Asp Ser Ser Leu Trp Thr Thr Leu Leu Ile Arg Asn Pro Cys 
            260                 265                 270         


Arg Lys Ile Leu Glu Phe Leu Tyr Ser Thr Ser Tyr Asn Met Asp Arg 
        275                 280                 285             


Phe Ile Asn Lys 
    290         


<210>  5180
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD11B1L__Homo_sapiens__NP_001254797

<400>  5180

Met Ala Asn Leu Gly Thr Leu Gln Leu Leu Pro Pro Arg Phe Lys Arg 
1               5                   10                  15      


Phe Ser Cys Leu Ser Leu Pro Asn Ile Trp Ile Thr Gly Met Pro Val 
            20                  25                  30          


Pro Ala Thr Ser Val Pro Cys Pro Ser Ala Gly Pro His Arg Thr Met 
        35                  40                  45              


Lys Val Leu Leu Leu Thr Gly Leu Gly Ala Leu Phe Phe Ala Tyr Tyr 
    50                  55                  60                  


Trp Asp Asp Asn Phe Asp Pro Ala Ser Leu Gln Gly Ala Arg Val Leu 
65                  70                  75                  80  


Leu Thr Gly Ala Asn Ala Gly Val Gly Glu Glu Leu Ala Tyr His Tyr 
                85                  90                  95      


Ala Arg Leu Gly Ser His Leu Val Leu Thr Ala His Thr Glu Ala Leu 
            100                 105                 110         


Leu Gln Lys Val Val Gly Asn Cys Arg Lys Leu Gly Ala Pro Lys Val 
        115                 120                 125             


Phe Tyr Ile Ala Ala Asp Met Ala Ser Pro Glu Ala Pro Glu Ser Val 
    130                 135                 140                 


Val Gln Phe Ala Leu Asp Lys Leu Gly Gly Leu Asp Tyr Leu Val Leu 
145                 150                 155                 160 


Asn His Ile Gly Gly Ala Pro Ala Gly Thr Arg Ala Arg Ser Pro Gln 
                165                 170                 175     


Ala Thr Arg Trp Leu Met Gln Val Asn Phe Val Ser Tyr Val Gln Leu 
            180                 185                 190         


Thr Ser Arg Ala Leu Pro Ser Leu Thr Asp Ser Lys Gly Ser Leu Val 
        195                 200                 205             


Val Val Ser Ser Leu Leu Gly Arg Val Pro Thr Ser Phe Ser Thr Pro 
    210                 215                 220                 


Tyr Ser Ala Ala Lys Phe Ala Leu Asp Gly Phe Phe Gly Ser Leu Arg 
225                 230                 235                 240 


Arg Glu Leu Asp Val Gln Asp Val Asn Val Ala Ile Thr Met Cys Val 
                245                 250                 255     


Leu Gly Leu Arg Asp Arg Ala Ser Ala Ala Glu Ala Val Arg Gly Val 
            260                 265                 270         


Thr Arg Val Lys Ala Ala Pro Gly Pro Lys Ala Ala Leu Ala Val Ile 
        275                 280                 285             


Arg Gly Gly Ala Thr Arg Ala Ala Gly Val Phe Tyr Pro Trp Arg Phe 
    290                 295                 300                 


Arg Leu Leu Cys Leu Leu Arg Arg Trp Leu Pro Arg Pro Arg Ala Trp 
305                 310                 315                 320 


Phe Ile Arg Gln Glu Leu Asn Val Thr Ala Ala Ala Ala 
                325                 330             


<210>  5181
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD11B2__Homo_sapiens__NP_000187

<400>  5181

Met Glu Arg Trp Pro Trp Pro Ser Gly Gly Ala Trp Leu Leu Val Ala 
1               5                   10                  15      


Ala Arg Ala Leu Leu Gln Leu Leu Arg Ser Asp Leu Arg Leu Gly Arg 
            20                  25                  30          


Pro Leu Leu Ala Ala Leu Ala Leu Leu Ala Ala Leu Asp Trp Leu Cys 
        35                  40                  45              


Gln Arg Leu Leu Pro Pro Pro Ala Ala Leu Ala Val Leu Ala Ala Ala 
    50                  55                  60                  


Gly Trp Ile Ala Leu Ser Arg Leu Ala Arg Pro Gln Arg Leu Pro Val 
65                  70                  75                  80  


Ala Thr Arg Ala Val Leu Ile Thr Gly Cys Asp Ser Gly Phe Gly Lys 
                85                  90                  95      


Glu Thr Ala Lys Lys Leu Asp Ser Met Gly Phe Thr Val Leu Ala Thr 
            100                 105                 110         


Val Leu Glu Leu Asn Ser Pro Gly Ala Ile Glu Leu Arg Thr Cys Cys 
        115                 120                 125             


Ser Pro Arg Leu Arg Leu Leu Gln Met Asp Leu Thr Lys Pro Gly Asp 
    130                 135                 140                 


Ile Ser Arg Val Leu Glu Phe Thr Lys Ala His Thr Thr Ser Thr Gly 
145                 150                 155                 160 


Leu Trp Gly Leu Val Asn Asn Ala Gly His Asn Glu Val Val Ala Asp 
                165                 170                 175     


Ala Glu Leu Ser Pro Val Ala Thr Phe Arg Ser Cys Met Glu Val Asn 
            180                 185                 190         


Phe Phe Gly Ala Leu Glu Leu Thr Lys Gly Leu Leu Pro Leu Leu Arg 
        195                 200                 205             


Ser Ser Arg Gly Arg Ile Val Thr Val Gly Ser Pro Ala Gly Asp Met 
    210                 215                 220                 


Pro Tyr Pro Cys Leu Gly Ala Tyr Gly Thr Ser Lys Ala Ala Val Ala 
225                 230                 235                 240 


Leu Leu Met Asp Thr Phe Ser Cys Glu Leu Leu Pro Trp Gly Val Lys 
                245                 250                 255     


Val Ser Ile Ile Gln Pro Gly Cys Phe Lys Thr Glu Ser Val Arg Asn 
            260                 265                 270         


Val Gly Gln Trp Glu Lys Arg Lys Gln Leu Leu Leu Ala Asn Leu Pro 
        275                 280                 285             


Gln Glu Leu Leu Gln Ala Tyr Gly Lys Asp Tyr Ile Glu His Leu His 
    290                 295                 300                 


Gly Gln Phe Leu His Ser Leu Arg Leu Ala Met Ser Asp Leu Thr Pro 
305                 310                 315                 320 


Val Val Asp Ala Ile Thr Asp Ala Leu Leu Ala Ala Arg Pro Arg Arg 
                325                 330                 335     


Arg Tyr Tyr Pro Gly Gln Gly Leu Gly Leu Met Tyr Phe Ile His Tyr 
            340                 345                 350         


Tyr Leu Pro Glu Gly Leu Arg Arg Arg Phe Leu Gln Ala Phe Phe Ile 
        355                 360                 365             


Ser His Cys Leu Pro Arg Ala Leu Gln Pro Gly Gln Pro Gly Thr Thr 
    370                 375                 380                 


Pro Pro Gln Asp Ala Ala Gln Asp Pro Asn Leu Ser Pro Gly Pro Ser 
385                 390                 395                 400 


Pro Ala Val Ala Arg 
                405 


<210>  5182
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B10__Homo_sapiens__NP_001032900

<400>  5182

Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly 
            20                  25                  30          


Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu 
        35                  40                  45              


Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp 
    50                  55                  60                  


Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly 
65                  70                  75                  80  


Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val 
                85                  90                  95      


Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu 
            100                 105                 110         


Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val 
        115                 120                 125             


Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly 
    130                 135                 140                 


Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu 
145                 150                 155                 160 


Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val 
                165                 170                 175     


Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Leu Phe 
            180                 185                 190         


Gly Thr Pro Leu Leu Thr Ser Leu Pro Glu Lys Val Cys Asn Phe Leu 
        195                 200                 205             


Ala Ser Gln Val Pro Phe Pro Ser Arg Leu Gly Asp Pro Ala Glu Tyr 
    210                 215                 220                 


Ala His Leu Val Gln Ala Ile Ile Glu Asn Pro Phe Leu Asn Gly Glu 
225                 230                 235                 240 


Val Ile Arg Leu Asp Gly Ala Ile Arg Met Gln Pro 
                245                 250         


<210>  5183
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B11__Homo_sapiens__NP_057329

<400>  5183

Met Lys Phe Leu Leu Asp Ile Leu Leu Leu Leu Pro Leu Leu Ile Val 
1               5                   10                  15      


Cys Ser Leu Glu Ser Phe Val Lys Leu Phe Ile Pro Lys Arg Arg Lys 
            20                  25                  30          


Ser Val Thr Gly Glu Ile Val Leu Ile Thr Gly Ala Gly His Gly Ile 
        35                  40                  45              


Gly Arg Leu Thr Ala Tyr Glu Phe Ala Lys Leu Lys Ser Lys Leu Val 
    50                  55                  60                  


Leu Trp Asp Ile Asn Lys His Gly Leu Glu Glu Thr Ala Ala Lys Cys 
65                  70                  75                  80  


Lys Gly Leu Gly Ala Lys Val His Thr Phe Val Val Asp Cys Ser Asn 
                85                  90                  95      


Arg Glu Asp Ile Tyr Ser Ser Ala Lys Lys Val Lys Ala Glu Ile Gly 
            100                 105                 110         


Asp Val Ser Ile Leu Val Asn Asn Ala Gly Val Val Tyr Thr Ser Asp 
        115                 120                 125             


Leu Phe Ala Thr Gln Asp Pro Gln Ile Glu Lys Thr Phe Glu Val Asn 
    130                 135                 140                 


Val Leu Ala His Phe Trp Thr Thr Lys Ala Phe Leu Pro Ala Met Thr 
145                 150                 155                 160 


Lys Asn Asn His Gly His Ile Val Thr Val Ala Ser Ala Ala Gly His 
                165                 170                 175     


Val Ser Val Pro Phe Leu Leu Ala Tyr Cys Ser Ser Lys Phe Ala Ala 
            180                 185                 190         


Val Gly Phe His Lys Thr Leu Thr Asp Glu Leu Ala Ala Leu Gln Ile 
        195                 200                 205             


Thr Gly Val Lys Thr Thr Cys Leu Cys Pro Asn Phe Val Asn Thr Gly 
    210                 215                 220                 


Phe Ile Lys Asn Pro Ser Thr Ser Leu Gly Pro Thr Leu Glu Pro Glu 
225                 230                 235                 240 


Glu Val Val Asn Arg Leu Met His Gly Ile Leu Thr Glu Gln Lys Met 
                245                 250                 255     


Ile Phe Ile Pro Ser Ser Ile Ala Phe Leu Thr Thr Leu Glu Arg Ile 
            260                 265                 270         


Leu Pro Glu Arg Phe Leu Ala Val Leu Lys Arg Lys Ile Ser Val Lys 
        275                 280                 285             


Phe Asp Ala Val Ile Gly Tyr Lys Met Lys Ala Gln 
    290                 295                 300 


<210>  5184
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B12__Homo_sapiens__NP_057226

<400>  5184

Met Glu Ser Ala Leu Pro Ala Ala Gly Phe Leu Tyr Trp Val Gly Ala 
1               5                   10                  15      


Gly Thr Val Ala Tyr Leu Ala Leu Arg Ile Ser Tyr Ser Leu Phe Thr 
            20                  25                  30          


Ala Leu Arg Val Trp Gly Val Gly Asn Glu Ala Gly Val Gly Pro Gly 
        35                  40                  45              


Leu Gly Glu Trp Ala Val Val Thr Gly Ser Thr Asp Gly Ile Gly Lys 
    50                  55                  60                  


Ser Tyr Ala Glu Glu Leu Ala Lys His Gly Met Lys Val Val Leu Ile 
65                  70                  75                  80  


Ser Arg Ser Lys Asp Lys Leu Asp Gln Val Ser Ser Glu Ile Lys Glu 
                85                  90                  95      


Lys Phe Lys Val Glu Thr Arg Thr Ile Ala Val Asp Phe Ala Ser Glu 
            100                 105                 110         


Asp Ile Tyr Asp Lys Ile Lys Thr Gly Leu Ala Gly Leu Glu Ile Gly 
        115                 120                 125             


Ile Leu Val Asn Asn Val Gly Met Ser Tyr Glu Tyr Pro Glu Tyr Phe 
    130                 135                 140                 


Leu Asp Val Pro Asp Leu Asp Asn Val Ile Lys Lys Met Ile Asn Ile 
145                 150                 155                 160 


Asn Ile Leu Ser Val Cys Lys Met Thr Gln Leu Val Leu Pro Gly Met 
                165                 170                 175     


Val Glu Arg Ser Lys Gly Ala Ile Leu Asn Ile Ser Ser Gly Ser Gly 
            180                 185                 190         


Met Leu Pro Val Pro Leu Leu Thr Ile Tyr Ser Ala Thr Lys Thr Phe 
        195                 200                 205             


Val Asp Phe Phe Ser Gln Cys Leu His Glu Glu Tyr Arg Ser Lys Gly 
    210                 215                 220                 


Val Phe Val Gln Ser Val Leu Pro Tyr Phe Val Ala Thr Lys Leu Ala 
225                 230                 235                 240 


Lys Ile Arg Lys Pro Thr Leu Asp Lys Pro Ser Pro Glu Thr Phe Val 
                245                 250                 255     


Lys Ser Ala Ile Lys Thr Val Gly Leu Gln Ser Arg Thr Asn Gly Tyr 
            260                 265                 270         


Leu Ile His Ala Leu Met Gly Ser Ile Ile Ser Asn Leu Pro Ser Trp 
        275                 280                 285             


Ile Tyr Leu Lys Ile Val Met Asn Met Asn Lys Ser Thr Arg Ala His 
    290                 295                 300                 


Tyr Leu Lys Lys Thr Lys Lys Asn 
305                 310         


<210>  5185
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B13__Homo_sapiens__NP_001129702

<400>  5185

Met Asn Ile Ile Leu Glu Ile Leu Leu Leu Leu Ile Thr Ile Ile Tyr 
1               5                   10                  15      


Ser Tyr Leu Glu Ser Leu Val Lys Phe Phe Ile Pro Gln Arg Arg Lys 
            20                  25                  30          


Ser Val Ala Gly Glu Ile Val Leu Ile Thr Gly Ala Gly His Gly Ile 
        35                  40                  45              


Gly Arg Gln Thr Thr Tyr Glu Phe Ala Lys Arg Gln Ser Ile Leu Val 
    50                  55                  60                  


Leu Trp Asp Ile Asn Lys Val Lys Lys Glu Val Gly Asp Val Thr Ile 
65                  70                  75                  80  


Val Val Asn Asn Ala Gly Thr Val Tyr Pro Ala Asp Leu Leu Ser Thr 
                85                  90                  95      


Lys Asp Glu Glu Ile Thr Lys Thr Phe Glu Val Asn Ile Leu Gly His 
            100                 105                 110         


Phe Trp Ile Thr Lys Ala Leu Leu Pro Ser Met Met Glu Arg Asn His 
        115                 120                 125             


Gly His Ile Val Thr Val Ala Ser Val Cys Gly His Glu Gly Ile Pro 
    130                 135                 140                 


Tyr Leu Ile Pro Tyr Cys Ser Ser Lys Phe Ala Ala Val Gly Phe His 
145                 150                 155                 160 


Arg Gly Leu Thr Ser Glu Leu Gln Ala Leu Gly Lys Thr Gly Ile Lys 
                165                 170                 175     


Thr Ser Cys Leu Cys Pro Val Phe Val Asn Thr Gly Phe Thr Lys Asn 
            180                 185                 190         


Pro Ser Thr Arg Leu Trp Pro Val Leu Glu Thr Asp Glu Val Val Arg 
        195                 200                 205             


Ser Leu Ile Asp Gly Ile Leu Thr Asn Lys Lys Met Ile Phe Val Pro 
    210                 215                 220                 


Ser Tyr Ile Asn Ile Phe Leu Arg Leu Gln Lys Phe Leu Pro Glu Arg 
225                 230                 235                 240 


Ala Ser Ala Ile Leu Asn Arg Met Gln Asn Ile Gln Phe Glu Ala Val 
                245                 250                 255     


Val Gly His Lys Ile Lys Met Lys 
            260                 


<210>  5186
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B14__Homo_sapiens__NP_057330

<400>  5186

Met Ala Thr Gly Thr Arg Tyr Ala Gly Lys Val Val Val Val Thr Gly 
1               5                   10                  15      


Gly Gly Arg Gly Ile Gly Ala Gly Ile Val Arg Ala Phe Val Asn Ser 
            20                  25                  30          


Gly Ala Arg Val Val Ile Cys Asp Lys Asp Glu Ser Gly Gly Arg Ala 
        35                  40                  45              


Leu Glu Gln Glu Leu Pro Gly Ala Val Phe Ile Leu Cys Asp Val Thr 
    50                  55                  60                  


Gln Glu Asp Asp Val Lys Thr Leu Val Ser Glu Thr Ile Arg Arg Phe 
65                  70                  75                  80  


Gly Arg Leu Asp Cys Val Val Asn Asn Ala Gly His His Pro Pro Pro 
                85                  90                  95      


Gln Arg Pro Glu Glu Thr Ser Ala Gln Gly Phe Arg Gln Leu Leu Glu 
            100                 105                 110         


Leu Asn Leu Leu Gly Thr Tyr Thr Leu Thr Lys Leu Ala Leu Pro Tyr 
        115                 120                 125             


Leu Arg Lys Ser Gln Gly Asn Val Ile Asn Ile Ser Ser Leu Val Gly 
    130                 135                 140                 


Ala Ile Gly Gln Ala Gln Ala Val Pro Tyr Val Ala Thr Lys Gly Ala 
145                 150                 155                 160 


Val Thr Ala Met Thr Lys Ala Leu Ala Leu Asp Glu Ser Pro Tyr Gly 
                165                 170                 175     


Val Arg Val Asn Cys Ile Ser Pro Gly Asn Ile Trp Thr Pro Leu Trp 
            180                 185                 190         


Glu Glu Leu Ala Ala Leu Met Pro Asp Pro Arg Ala Thr Ile Arg Glu 
        195                 200                 205             


Gly Met Leu Ala Gln Pro Leu Gly Arg Met Gly Gln Pro Ala Glu Val 
    210                 215                 220                 


Gly Ala Ala Ala Val Phe Leu Ala Ser Glu Ala Asn Phe Cys Thr Gly 
225                 230                 235                 240 


Ile Glu Leu Leu Val Thr Gly Gly Ala Glu Leu Gly Tyr Gly Cys Lys 
                245                 250                 255     


Ala Ser Arg Ser Thr Pro Val Asp Ala Pro Asp Ile Pro Ser 
            260                 265                 270 


<210>  5187
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B1__Homo_sapiens__NP_000404

<400>  5187

Met Ala Arg Thr Val Val Leu Ile Thr Gly Cys Ser Ser Gly Ile Gly 
1               5                   10                  15      


Leu His Leu Ala Val Arg Leu Ala Ser Asp Pro Ser Gln Ser Phe Lys 
            20                  25                  30          


Val Tyr Ala Thr Leu Arg Asp Leu Lys Thr Gln Gly Arg Leu Trp Glu 
        35                  40                  45              


Ala Ala Arg Ala Leu Ala Cys Pro Pro Gly Ser Leu Glu Thr Leu Gln 
    50                  55                  60                  


Leu Asp Val Arg Asp Ser Lys Ser Val Ala Ala Ala Arg Glu Arg Val 
65                  70                  75                  80  


Thr Glu Gly Arg Val Asp Val Leu Val Cys Asn Ala Gly Leu Gly Leu 
                85                  90                  95      


Leu Gly Pro Leu Glu Ala Leu Gly Glu Asp Ala Val Ala Ser Val Leu 
            100                 105                 110         


Asp Val Asn Val Val Gly Thr Val Arg Met Leu Gln Ala Phe Leu Pro 
        115                 120                 125             


Asp Met Lys Arg Arg Gly Ser Gly Arg Val Leu Val Thr Gly Ser Val 
    130                 135                 140                 


Gly Gly Leu Met Gly Leu Pro Phe Asn Asp Val Tyr Cys Ala Ser Lys 
145                 150                 155                 160 


Phe Ala Leu Glu Gly Leu Cys Glu Ser Leu Ala Val Leu Leu Leu Pro 
                165                 170                 175     


Phe Gly Val His Leu Ser Leu Ile Glu Cys Gly Pro Val His Thr Ala 
            180                 185                 190         


Phe Met Glu Lys Val Leu Gly Ser Pro Glu Glu Val Leu Asp Arg Thr 
        195                 200                 205             


Asp Ile His Thr Phe His Arg Phe Tyr Gln Tyr Leu Ala His Ser Lys 
    210                 215                 220                 


Gln Val Phe Arg Glu Ala Ala Gln Asn Pro Glu Glu Val Ala Glu Val 
225                 230                 235                 240 


Phe Leu Thr Ala Leu Arg Ala Pro Lys Pro Thr Leu Arg Tyr Phe Thr 
                245                 250                 255     


Thr Glu Arg Phe Leu Pro Leu Leu Arg Met Arg Leu Asp Asp Pro Ser 
            260                 265                 270         


Gly Ser Asn Tyr Val Thr Ala Met His Arg Glu Val Phe Gly Asp Val 
        275                 280                 285             


Pro Ala Lys Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Gly Pro 
    290                 295                 300                 


Gly Ala Glu Asp Glu Ala Gly Arg Gly Ala Val Gly Asp Pro Glu Leu 
305                 310                 315                 320 


Gly Asp Pro Pro Ala Ala Pro Gln 
                325             


<210>  5188
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B2__Homo_sapiens__NP_002144

<400>  5188

Met Ser Thr Phe Phe Ser Asp Thr Ala Trp Ile Cys Leu Ala Val Pro 
1               5                   10                  15      


Thr Val Leu Cys Gly Thr Val Phe Cys Lys Tyr Lys Lys Ser Ser Gly 
            20                  25                  30          


Gln Leu Trp Ser Trp Met Val Cys Leu Ala Gly Leu Cys Ala Val Cys 
        35                  40                  45              


Leu Leu Ile Leu Ser Pro Phe Trp Gly Leu Ile Leu Phe Ser Val Ser 
    50                  55                  60                  


Cys Phe Leu Met Tyr Thr Tyr Leu Ser Gly Gln Glu Leu Leu Pro Val 
65                  70                  75                  80  


Asp Gln Lys Ala Val Leu Val Thr Gly Gly Asp Cys Gly Leu Gly His 
                85                  90                  95      


Ala Leu Cys Lys Tyr Leu Asp Glu Leu Gly Phe Thr Val Phe Ala Gly 
            100                 105                 110         


Val Leu Asn Glu Asn Gly Pro Gly Ala Glu Glu Leu Arg Arg Thr Cys 
        115                 120                 125             


Ser Pro Arg Leu Ser Val Leu Gln Met Asp Ile Thr Lys Pro Val Gln 
    130                 135                 140                 


Ile Lys Asp Ala Tyr Ser Lys Val Ala Ala Met Leu Gln Asp Arg Gly 
145                 150                 155                 160 


Leu Trp Ala Val Ile Asn Asn Ala Gly Val Leu Gly Phe Pro Thr Asp 
                165                 170                 175     


Gly Glu Leu Leu Leu Met Thr Asp Tyr Lys Gln Cys Met Ala Val Asn 
            180                 185                 190         


Phe Phe Gly Thr Val Glu Val Thr Lys Thr Phe Leu Pro Leu Leu Arg 
        195                 200                 205             


Lys Ser Lys Gly Arg Leu Val Asn Val Ser Ser Met Gly Gly Gly Ala 
    210                 215                 220                 


Pro Met Glu Arg Leu Ala Ser Tyr Gly Ser Ser Lys Ala Ala Val Thr 
225                 230                 235                 240 


Met Phe Ser Ser Val Met Arg Leu Glu Leu Ser Lys Trp Gly Ile Lys 
                245                 250                 255     


Val Ala Ser Ile Gln Pro Gly Gly Phe Leu Thr Asn Ile Ala Gly Thr 
            260                 265                 270         


Ser Asp Lys Trp Glu Lys Leu Glu Lys Asp Ile Leu Asp His Leu Pro 
        275                 280                 285             


Ala Glu Val Gln Glu Asp Tyr Gly Gln Asp Tyr Ile Leu Ala Gln Arg 
    290                 295                 300                 


Asn Phe Leu Leu Leu Ile Asn Ser Leu Ala Ser Lys Asp Phe Ser Pro 
305                 310                 315                 320 


Val Leu Arg Asp Ile Gln His Ala Ile Leu Ala Lys Ser Pro Phe Ala 
                325                 330                 335     


Tyr Tyr Thr Pro Gly Lys Gly Ala Tyr Leu Trp Ile Cys Leu Ala His 
            340                 345                 350         


Tyr Leu Pro Ile Gly Ile Tyr Asp Tyr Phe Ala Lys Arg His Phe Gly 
        355                 360                 365             


Gln Asp Lys Pro Met Pro Arg Ala Leu Arg Met Pro Asn Tyr Lys Lys 
    370                 375                 380                 


Lys Ala Thr 
385         


<210>  5189
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B3__Homo_sapiens__NP_000188

<400>  5189

Met Gly Asp Val Leu Glu Gln Phe Phe Ile Leu Thr Gly Leu Leu Val 
1               5                   10                  15      


Cys Leu Ala Cys Leu Ala Lys Cys Val Arg Phe Ser Arg Cys Val Leu 
            20                  25                  30          


Leu Asn Tyr Trp Lys Val Leu Pro Lys Ser Phe Leu Arg Ser Met Gly 
        35                  40                  45              


Gln Trp Ala Val Ile Thr Gly Ala Gly Asp Gly Ile Gly Lys Ala Tyr 
    50                  55                  60                  


Ser Phe Glu Leu Ala Lys Arg Gly Leu Asn Val Val Leu Ile Ser Arg 
65                  70                  75                  80  


Thr Leu Glu Lys Leu Glu Ala Ile Ala Thr Glu Ile Glu Arg Thr Thr 
                85                  90                  95      


Gly Arg Ser Val Lys Ile Ile Gln Ala Asp Phe Thr Lys Asp Asp Ile 
            100                 105                 110         


Tyr Glu His Ile Lys Glu Lys Leu Ala Gly Leu Glu Ile Gly Ile Leu 
        115                 120                 125             


Val Asn Asn Val Gly Met Leu Pro Asn Leu Leu Pro Ser His Phe Leu 
    130                 135                 140                 


Asn Ala Pro Asp Glu Ile Gln Ser Leu Ile His Cys Asn Ile Thr Ser 
145                 150                 155                 160 


Val Val Lys Met Thr Gln Leu Ile Leu Lys His Met Glu Ser Arg Gln 
                165                 170                 175     


Lys Gly Leu Ile Leu Asn Ile Ser Ser Gly Ile Ala Leu Phe Pro Trp 
            180                 185                 190         


Pro Leu Tyr Ser Met Tyr Ser Ala Ser Lys Ala Phe Val Cys Ala Phe 
        195                 200                 205             


Ser Lys Ala Leu Gln Glu Glu Tyr Lys Ala Lys Glu Val Ile Ile Gln 
    210                 215                 220                 


Val Leu Thr Pro Tyr Ala Val Ser Thr Ala Met Thr Lys Tyr Leu Asn 
225                 230                 235                 240 


Thr Asn Val Ile Thr Lys Thr Ala Asp Glu Phe Val Lys Glu Ser Leu 
                245                 250                 255     


Asn Tyr Val Thr Ile Gly Gly Glu Thr Cys Gly Cys Leu Ala His Glu 
            260                 265                 270         


Ile Leu Ala Gly Phe Leu Ser Leu Ile Pro Ala Trp Ala Phe Tyr Ser 
        275                 280                 285             


Gly Ala Phe Gln Arg Leu Leu Leu Thr His Tyr Val Ala Tyr Leu Lys 
    290                 295                 300                 


Leu Asn Thr Lys Val Arg 
305                 310 


<210>  5190
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B4__Homo_sapiens__NP_000405

<400>  5190

Met Gly Ser Pro Leu Arg Phe Asp Gly Arg Val Val Leu Val Thr Gly 
1               5                   10                  15      


Ala Gly Ala Gly Leu Gly Arg Ala Tyr Ala Leu Ala Phe Ala Glu Arg 
            20                  25                  30          


Gly Ala Leu Val Val Val Asn Asp Leu Gly Gly Asp Phe Lys Gly Val 
        35                  40                  45              


Gly Lys Gly Ser Leu Ala Ala Asp Lys Val Val Glu Glu Ile Arg Arg 
    50                  55                  60                  


Arg Gly Gly Lys Ala Val Ala Asn Tyr Asp Ser Val Glu Glu Gly Glu 
65                  70                  75                  80  


Lys Val Val Lys Thr Ala Leu Asp Ala Phe Gly Arg Ile Asp Val Val 
                85                  90                  95      


Val Asn Asn Ala Gly Ile Leu Arg Asp Arg Ser Phe Ala Arg Ile Ser 
            100                 105                 110         


Asp Glu Asp Trp Asp Ile Ile His Arg Val His Leu Arg Gly Ser Phe 
        115                 120                 125             


Gln Val Thr Arg Ala Ala Trp Glu His Met Lys Lys Gln Lys Tyr Gly 
    130                 135                 140                 


Arg Ile Ile Met Thr Ser Ser Ala Ser Gly Ile Tyr Gly Asn Phe Gly 
145                 150                 155                 160 


Gln Ala Asn Tyr Ser Ala Ala Lys Leu Gly Leu Leu Gly Leu Ala Asn 
                165                 170                 175     


Ser Leu Ala Ile Glu Gly Arg Lys Ser Asn Ile His Cys Asn Thr Ile 
            180                 185                 190         


Ala Pro Asn Ala Gly Ser Arg Met Thr Gln Thr Val Met Pro Glu Asp 
        195                 200                 205             


Leu Val Glu Ala Leu Lys Pro Glu Tyr Val Ala Pro Leu Val Leu Trp 
    210                 215                 220                 


Leu Cys His Glu Ser Cys Glu Glu Asn Gly Gly Leu Phe Glu Val Gly 
225                 230                 235                 240 


Ala Gly Trp Ile Gly Lys Leu Arg Trp Glu Arg Thr Leu Gly Ala Ile 
                245                 250                 255     


Val Arg Gln Lys Asn His Pro Met Thr Pro Glu Ala Val Lys Ala Asn 
            260                 265                 270         


Trp Lys Lys Ile Cys Asp Phe Glu Asn Ala Ser Lys Pro Gln Ser Ile 
        275                 280                 285             


Gln Glu Ser Thr Gly Ser Ile Ile Glu Val Leu Ser Lys Ile Asp Ser 
    290                 295                 300                 


Glu Gly Gly Val Ser Ala Asn His Thr Ser Arg Ala Thr Ser Thr Ala 
305                 310                 315                 320 


Thr Ser Gly Phe Ala Gly Ala Ile Gly Gln Lys Leu Pro Pro Phe Ser 
                325                 330                 335     


Tyr Ala Tyr Thr Glu Leu Glu Ala Ile Met Tyr Ala Leu Gly Val Gly 
            340                 345                 350         


Ala Ser Ile Lys Asp Pro Lys Asp Leu Lys Phe Ile Tyr Glu Gly Ser 
        355                 360                 365             


Ser Asp Phe Ser Cys Leu Pro Thr Phe Gly Val Ile Ile Gly Gln Lys 
    370                 375                 380                 


Ser Met Met Gly Gly Gly Leu Ala Glu Ile Pro Gly Leu Ser Ile Asn 
385                 390                 395                 400 


Phe Ala Lys Val Leu His Gly Glu Gln Tyr Leu Glu Leu Tyr Lys Pro 
                405                 410                 415     


Leu Pro Arg Ala Gly Lys Leu Lys Cys Glu Ala Val Val Ala Asp Val 
            420                 425                 430         


Leu Asp Lys Gly Ser Gly Val Val Ile Ile Met Asp Val Tyr Ser Tyr 
        435                 440                 445             


Ser Glu Lys Glu Leu Ile Cys His Asn Gln Phe Ser Leu Phe Leu Val 
    450                 455                 460                 


Gly Ser Gly Gly Phe Gly Gly Lys Arg Thr Ser Asp Lys Val Lys Val 
465                 470                 475                 480 


Ala Val Ala Ile Pro Asn Arg Pro Pro Asp Ala Val Leu Thr Asp Thr 
                485                 490                 495     


Thr Ser Leu Asn Gln Ala Ala Leu Tyr Arg Leu Ser Gly Asp Trp Asn 
            500                 505                 510         


Pro Leu His Ile Asp Pro Asn Phe Ala Ser Leu Ala Gly Phe Asp Lys 
        515                 520                 525             


Pro Ile Leu His Gly Leu Cys Thr Phe Gly Phe Ser Ala Arg Arg Val 
    530                 535                 540                 


Leu Gln Gln Phe Ala Asp Asn Asp Val Ser Arg Phe Lys Ala Ile Lys 
545                 550                 555                 560 


Ala Arg Phe Ala Lys Pro Val Tyr Pro Gly Gln Thr Leu Gln Thr Glu 
                565                 570                 575     


Met Trp Lys Glu Gly Asn Arg Ile His Phe Gln Thr Lys Val Gln Glu 
            580                 585                 590         


Thr Gly Asp Ile Val Ile Ser Asn Ala Tyr Val Asp Leu Ala Pro Thr 
        595                 600                 605             


Ser Gly Thr Ser Ala Lys Thr Pro Ser Glu Gly Gly Lys Leu Gln Ser 
    610                 615                 620                 


Thr Phe Val Phe Glu Glu Ile Gly Arg Arg Leu Lys Asp Ile Gly Pro 
625                 630                 635                 640 


Glu Val Val Lys Lys Val Asn Ala Val Phe Glu Trp His Ile Thr Lys 
                645                 650                 655     


Gly Gly Asn Ile Gly Ala Lys Trp Thr Ile Asp Leu Lys Ser Gly Ser 
            660                 665                 670         


Gly Lys Val Tyr Gln Gly Pro Ala Lys Gly Ala Ala Asp Thr Thr Ile 
        675                 680                 685             


Ile Leu Ser Asp Glu Asp Phe Met Glu Val Val Leu Gly Lys Leu Asp 
    690                 695                 700                 


Pro Gln Lys Ala Phe Phe Ser Gly Arg Leu Lys Ala Arg Gly Asn Ile 
705                 710                 715                 720 


Met Leu Ser Gln Lys Leu Gln Met Ile Leu Lys Asp Tyr Ala Lys Leu 
                725                 730                 735     


<210>  5191
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B6__Homo_sapiens__XP_006719735

<400>  5191

Met Trp Leu Tyr Leu Ala Ala Phe Val Gly Leu Tyr Tyr Leu Leu His 
1               5                   10                  15      


Trp Tyr Arg Glu Arg Gln Val Val Ser His Leu Gln Asp Lys Tyr Val 
            20                  25                  30          


Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Leu Ala Arg Gln 
        35                  40                  45              


Leu Asp Ala Arg Gly Leu Arg Val Leu Ala Ala Cys Leu Thr Glu Lys 
    50                  55                  60                  


Gly Ala Glu Gln Leu Arg Gly Gln Thr Ser Asp Arg Leu Glu Thr Val 
65                  70                  75                  80  


Thr Leu Asp Val Thr Lys Met Glu Ser Ile Ala Ala Ala Thr Gln Trp 
                85                  90                  95      


Val Lys Glu His Val Gly Asp Arg Gly Leu Trp Gly Leu Val Asn Asn 
            100                 105                 110         


Ala Gly Ile Leu Thr Pro Ile Thr Leu Cys Glu Trp Leu Asn Thr Glu 
        115                 120                 125             


Asp Ser Met Asn Met Leu Lys Val Asn Leu Ile Gly Val Ile Gln Val 
    130                 135                 140                 


Thr Leu Ser Met Leu Pro Leu Val Arg Arg Ala Arg Gly Arg Ile Val 
145                 150                 155                 160 


Asn Val Ser Ser Ile Leu Gly Arg Val Ala Phe Phe Val Gly Gly Tyr 
                165                 170                 175     


Cys Val Ser Lys Tyr Gly Val Glu Ala Phe Ser Asp Ile Leu Arg Arg 
            180                 185                 190         


Glu Ile Gln His Phe Gly Val Lys Ile Ser Ile Val Glu Pro Gly Tyr 
        195                 200                 205             


Phe Arg Thr Gly Met Thr Asn Met Thr Gln Ser Leu Glu Arg Met Lys 
    210                 215                 220                 


Gln Ser Trp Lys Glu Ala Pro Lys His Ile Lys Glu Thr Tyr Gly Gln 
225                 230                 235                 240 


Gln Tyr Phe Asp Ala Leu Tyr Asn Ile Met Lys Glu Gly Leu Leu Asn 
                245                 250                 255     


Cys Ser Thr Asn Leu Asn Leu Val Thr Asp Cys Met Glu His Ala Leu 
            260                 265                 270         


Thr Ser Val His Pro Arg Thr Arg Tyr Ser Ala Gly Trp Asp Ala Lys 
        275                 280                 285             


Phe Phe Phe Ile Pro Leu Ser Tyr Leu Pro Thr Ser Leu Ala Asp Tyr 
    290                 295                 300                 


Ile Leu Thr Arg Ser Trp Pro Lys Pro Ala Gln Ala Val 
305                 310                 315         


<210>  5192
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B7__Homo_sapiens__NP_001291441

<400>  5192

Met Arg Lys Val Val Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      


Ala Leu Cys Lys Arg Leu Leu Ala Glu Asp Asp Glu Leu His Leu Cys 
            20                  25                  30          


Leu Ala Cys Arg Asn Met Ser Lys Ala Glu Ala Val Cys Ala Ala Leu 
        35                  40                  45              


Leu Ala Ser His Pro Thr Ala Glu Val Thr Ile Val Gln Val Asp Val 
    50                  55                  60                  


Ser Asn Leu Gln Ser Val Phe Arg Ala Ser Lys Glu Leu Lys Gln Arg 
65                  70                  75                  80  


Phe Gln Arg Leu Asp Cys Ile Tyr Leu Asn Ala Gly Ile Met Pro Asn 
                85                  90                  95      


Pro Gln Leu Asn Ile Lys Ala Leu Phe Phe Gly Leu Phe Ser Arg Lys 
            100                 105                 110         


Val Ile His Met Phe Ser Thr Ala Glu Gly Leu Leu Thr Gln Gly Asp 
        115                 120                 125             


Lys Ile Thr Ala Asp Gly Leu Gln Glu Val Phe Glu Thr Asn Val Phe 
    130                 135                 140                 


Gly His Phe Ile Leu Val Lys Lys Leu Trp Ala 
145                 150                 155 


<210>  5193
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD17B8__Homo_sapiens__NP_055049

<400>  5193

Met Ala Ser Gln Leu Gln Asn Arg Leu Arg Ser Ala Leu Ala Leu Val 
1               5                   10                  15      


Thr Gly Ala Gly Ser Gly Ile Gly Arg Ala Val Ser Val Arg Leu Ala 
            20                  25                  30          


Gly Glu Gly Ala Thr Val Ala Ala Cys Asp Leu Asp Arg Ala Ala Ala 
        35                  40                  45              


Gln Glu Thr Val Arg Leu Leu Gly Gly Pro Gly Ser Lys Glu Gly Pro 
    50                  55                  60                  


Pro Arg Gly Asn His Ala Ala Phe Gln Ala Asp Val Ser Glu Ala Arg 
65                  70                  75                  80  


Ala Ala Arg Cys Leu Leu Glu Gln Val Gln Ala Cys Phe Ser Arg Pro 
                85                  90                  95      


Pro Ser Val Val Val Ser Cys Ala Gly Ile Thr Gln Asp Glu Phe Leu 
            100                 105                 110         


Leu His Met Ser Glu Asp Asp Trp Asp Lys Val Ile Ala Val Asn Leu 
        115                 120                 125             


Lys Gly Thr Phe Leu Val Thr Gln Ala Ala Ala Gln Ala Leu Val Ser 
    130                 135                 140                 


Asn Gly Cys Arg Gly Ser Ile Ile Asn Ile Ser Ser Ile Val Gly Lys 
145                 150                 155                 160 


Val Gly Asn Val Gly Gln Thr Asn Tyr Ala Ala Ser Lys Ala Gly Val 
                165                 170                 175     


Ile Gly Leu Thr Gln Thr Ala Ala Arg Glu Leu Gly Arg His Gly Ile 
            180                 185                 190         


Arg Cys Asn Ser Val Leu Pro Gly Phe Ile Ala Thr Pro Met Thr Gln 
        195                 200                 205             


Lys Val Pro Gln Lys Val Val Asp Lys Ile Thr Glu Met Ile Pro Met 
    210                 215                 220                 


Gly His Leu Gly Asp Pro Glu Asp Val Ala Asp Val Val Ala Phe Leu 
225                 230                 235                 240 


Ala Ser Glu Asp Ser Gly Tyr Ile Thr Gly Thr Ser Val Glu Val Thr 
                245                 250                 255     


Gly Gly Leu Phe Met 
            260     


<210>  5194
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD3B1__Homo_sapiens__XP_011539616

<400>  5194

Met Ala Met Thr Gly Trp Ser Cys Leu Val Thr Gly Ala Gly Gly Phe 
1               5                   10                  15      


Leu Gly Gln Arg Ile Ile Arg Leu Leu Val Lys Glu Lys Glu Leu Lys 
            20                  25                  30          


Glu Ile Arg Val Leu Asp Lys Ala Phe Gly Pro Glu Leu Arg Glu Glu 
        35                  40                  45              


Phe Ser Lys Leu Gln Asn Lys Thr Lys Leu Thr Val Leu Glu Gly Asp 
    50                  55                  60                  


Ile Leu Asp Glu Pro Phe Leu Lys Arg Ala Cys Gln Asp Val Ser Val 
65                  70                  75                  80  


Ile Ile His Thr Ala Cys Ile Ile Asp Val Phe Gly Val Thr His Arg 
                85                  90                  95      


Glu Ser Ile Met Asn Val Asn Val Lys Gly Thr Gln Leu Leu Leu Glu 
            100                 105                 110         


Ala Cys Val Gln Ala Ser Val Pro Val Phe Ile Tyr Thr Ser Ser Ile 
        115                 120                 125             


Glu Val Ala Gly Pro Asn Ser Tyr Lys Glu Ile Ile Gln Asn Gly His 
    130                 135                 140                 


Glu Glu Glu Pro Leu Glu Asn Thr Trp Pro Ala Pro Tyr Pro His Ser 
145                 150                 155                 160 


Lys Lys Leu Ala Glu Lys Ala Val Leu Ala Ala Asn Gly Trp Asn Leu 
                165                 170                 175     


Lys Asn Gly Gly Thr Leu Tyr Thr Cys Ala Leu Arg Pro Met Tyr Ile 
            180                 185                 190         


Tyr Gly Glu Gly Ser Arg Phe Leu Ser Ala Ser Ile Asn Glu Ala Leu 
        195                 200                 205             


Asn Asn Asn Gly Ile Leu Ser Ser Val Gly Lys Phe Ser Thr Val Asn 
    210                 215                 220                 


Pro Val Tyr Val Gly Asn Val Ala Trp Ala His Ile Leu Ala Leu Arg 
225                 230                 235                 240 


Ala Leu Gln Asp Pro Lys Lys Ala Pro Ser Ile Arg Gly Gln Phe Tyr 
                245                 250                 255     


Tyr Ile Ser Asp Asp Thr Pro His Gln Ser Tyr Asp Asn Leu Asn Tyr 
            260                 265                 270         


Thr Leu Ser Lys Glu Phe Gly Leu Arg Leu Asp Ser Arg Trp Ser Phe 
        275                 280                 285             


Pro Leu Ser Leu Met Tyr Trp Ile Gly Phe Leu Leu Glu Ile Val Ser 
    290                 295                 300                 


Phe Leu Leu Arg Pro Ile Tyr Thr Tyr Arg Pro Pro Phe Asn Arg His 
305                 310                 315                 320 


Ile Val Thr Leu Ser Asn Ser Val Phe Thr Phe Ser Tyr Lys Lys Ala 
                325                 330                 335     


Gln Arg Asp Leu Ala Tyr Lys Pro Leu Tyr Ser Trp Glu Glu Ala Lys 
            340                 345                 350         


Gln Lys Thr Val Glu Trp Val Gly Ser Leu Val Asp Arg His Lys Glu 
        355                 360                 365             


Thr Leu Lys Ser Lys Thr Gln 
    370                 375 


<210>  5195
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSD3B7__Homo_sapiens__NP_001136250

<400>  5195

Met Ala Asp Ser Ala Gln Ala Gln Lys Leu Val Tyr Leu Val Thr Gly 
1               5                   10                  15      


Gly Cys Gly Phe Leu Gly Glu His Val Val Arg Met Leu Leu Gln Arg 
            20                  25                  30          


Glu Pro Arg Leu Gly Glu Leu Arg Val Phe Asp Gln His Leu Gly Pro 
        35                  40                  45              


Trp Leu Glu Glu Leu Lys Thr Gly Pro Val Arg Val Thr Ala Ile Gln 
    50                  55                  60                  


Gly Asp Val Thr Gln Ala His Glu Val Ala Ala Ala Val Ala Gly Ala 
65                  70                  75                  80  


His Val Val Ile His Thr Ala Gly Leu Val Asp Val Phe Gly Arg Ala 
                85                  90                  95      


Ser Pro Lys Thr Ile His Glu Val Asn Val Gln Gly Thr Arg Asn Val 
            100                 105                 110         


Ile Glu Ala Cys Val Gln Thr Gly Thr Arg Phe Leu Val Tyr Thr Ser 
        115                 120                 125             


Ser Met Glu Val Val Gly Pro Asn Thr Lys Gly His Pro Phe Tyr Arg 
    130                 135                 140                 


Gly Asn Glu Asp Thr Pro Tyr Glu Ala Val His Arg His Pro Tyr Pro 
145                 150                 155                 160 


Cys Ser Lys Ala Leu Ala Glu Trp Leu Val Leu Glu Ala Asn Gly Arg 
                165                 170                 175     


Lys Ala Met Leu Pro Gly Cys Thr Cys Trp Gln Pro Gly Ser Trp Ser 
            180                 185                 190         


Ser Gly Gln Pro 
        195     


<210>  5196
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSDL1__Homo_sapiens__NP_001139523

<400>  5196

Met Ala Ala Val Asp Ser Phe Tyr Leu Leu Tyr Arg Glu Ile Ala Arg 
1               5                   10                  15      


Ser Cys Asn Cys Tyr Met Glu Ala Leu Ala Leu Val Gly Ala Trp Tyr 
            20                  25                  30          


Thr Ala Arg Lys Ser Ile Thr Val Ile Cys Asp Phe Tyr Ser Leu Ile 
        35                  40                  45              


Arg Leu His Phe Ile Pro Arg Leu Gly Ser Arg Ala Asp Leu Ile Lys 
    50                  55                  60                  


Gln Tyr Gly Arg Trp Ala Val Val Ser Gly Ala Thr Asp Gly Ile Gly 
65                  70                  75                  80  


Lys Ala Tyr Ala Glu Glu Leu Ala Ser Arg Gly Leu Asn Ile Ile Leu 
                85                  90                  95      


Ile Ser Arg Asn Glu Glu Lys Leu Gln Tyr Phe Thr Gln Leu Ser Glu 
            100                 105                 110         


Asp Lys Leu Trp Asp Ile Ile Asn Val Asn Ile Ala Ala Ala Ser Leu 
        115                 120                 125             


Met Val His Val Val Leu Pro Gly Met Val Glu Arg Lys Lys Gly Ala 
    130                 135                 140                 


Ile Val Thr Ile Ser Ser Gly Ser Cys Cys Lys Pro Thr Pro Gln Leu 
145                 150                 155                 160 


Ala Ala Phe Ser Ala Ser Lys Ala Tyr Leu Asp His Phe Ser Arg Ala 
                165                 170                 175     


Leu Gln Tyr Glu Tyr Ala Ser Lys Gly Ile Phe Val Gln Ser Leu Ile 
            180                 185                 190         


Pro Phe Tyr Val Ala Thr Ser Met Thr Ala Pro Ser Asn Phe Leu His 
        195                 200                 205             


Arg Cys Ser Trp Leu Val Pro Ser Pro Lys Val Tyr Ala His His Ala 
    210                 215                 220                 


Val Ser Thr Leu Gly Ile Ser Lys Arg Thr Thr Gly Tyr Trp Ser His 
225                 230                 235                 240 


Ser Ile Gln Phe Leu Phe Ala Gln Tyr Met Pro Glu Trp Leu Trp Val 
                245                 250                 255     


Trp Gly Ala Asn Ile Leu Asn Arg Ser Leu Arg Lys Glu Ala Leu Ser 
            260                 265                 270         


Cys Thr Ala 
        275 


<210>  5197
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSDL2__Homo_sapiens__NP_001182751

<400>  5197

Met Leu Pro Asn Thr Gly Arg Leu Ala Gly Cys Thr Val Phe Ile Thr 
1               5                   10                  15      


Gly Ala Ser Arg Gly Ile Gly Lys Ala Ile Ala Leu Lys Ala Ala Lys 
            20                  25                  30          


Asp Gly Ala Asn Ile Val Ile Ala Ala Lys Thr Ala Gln Pro His Pro 
        35                  40                  45              


Lys Leu Leu Gly Thr Ile Tyr Thr Ala Ala Glu Glu Ile Glu Ala Val 
    50                  55                  60                  


Gly Gly Lys Ala Leu Pro Cys Ile Val Asp Val Arg Asp Glu Gln Gln 
65                  70                  75                  80  


Ile Ser Ala Ala Val Glu Lys Ala Ile Lys Lys Phe Gly Ala Tyr Thr 
                85                  90                  95      


Ile Ala Lys Tyr Gly Met Ser Met Tyr Val Leu Gly Met Ala Glu Glu 
            100                 105                 110         


Phe Lys Gly Glu Ile Ala Val Asn Ala Leu Trp Pro Lys Thr Ala Ile 
        115                 120                 125             


His Thr Ala Ala Met Asp Met Leu Gly Gly Pro Gly Ile Glu Ser Gln 
    130                 135                 140                 


Cys Arg Lys Val Asp Ile Ile Ala Asp Ala Ala Tyr Ser Ile Phe Gln 
145                 150                 155                 160 


Lys Pro Lys Ser Phe Thr Gly Asn Phe Val Ile Asp Glu Asn Ile Leu 
                165                 170                 175     


Lys Glu Glu Gly Ile Glu Asn Phe Asp Val Tyr Ala Ile Lys Pro Gly 
            180                 185                 190         


His Pro Leu Gln Pro Asp Phe Phe Leu Asp Glu Tyr Pro Glu Ala Val 
        195                 200                 205             


Ser Lys Lys Val Glu Ser Thr Gly Ala Val Pro Glu Phe Lys Glu Glu 
    210                 215                 220                 


Lys Leu Gln Leu Gln Pro Lys Pro Arg Ser Gly Ala Val Glu Glu Thr 
225                 230                 235                 240 


Phe Arg Ile Val Lys Asp Ser Leu Ser Asp Asp Val Val Lys Ala Thr 
                245                 250                 255     


Gln Ala Ile Tyr Leu Phe Glu Leu Ser Gly Glu Asp Gly Gly Thr Trp 
            260                 265                 270         


Phe Leu Asp Leu Lys Ser Lys Gly Gly Asn Val Gly Tyr Gly Glu Pro 
        275                 280                 285             


Ser Asp Gln Ala Asp Val Val Met Ser Met Thr Thr Asp Asp Phe Val 
    290                 295                 300                 


Lys Met Phe Ser Gly Lys Leu Lys Pro Thr Met Ala Phe Met Ser Gly 
305                 310                 315                 320 


Lys Leu Lys Ile Lys Gly Asn Met Ala Leu Ala Ile Lys Leu Glu Lys 
                325                 330                 335     


Leu Met Asn Gln Met Asn Ala Arg Leu 
            340                 345 


<210>  5198
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSF1__Homo_sapiens__NP_005517

<400>  5198

Met Asp Leu Pro Val Gly Pro Gly Ala Ala Gly Pro Ser Asn Val Pro 
1               5                   10                  15      


Ala Phe Leu Thr Lys Leu Trp Thr Leu Val Ser Asp Pro Asp Thr Asp 
            20                  25                  30          


Ala Leu Ile Cys Trp Ser Pro Ser Gly Asn Ser Phe His Val Phe Asp 
        35                  40                  45              


Gln Gly Gln Phe Ala Lys Glu Val Leu Pro Lys Tyr Phe Lys His Asn 
    50                  55                  60                  


Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe Arg Lys 
65                  70                  75                  80  


Val Val His Ile Glu Gln Gly Gly Leu Val Lys Pro Glu Arg Asp Asp 
                85                  90                  95      


Thr Glu Phe Gln His Pro Cys Phe Leu Arg Gly Gln Glu Gln Leu Leu 
            100                 105                 110         


Glu Asn Ile Lys Arg Lys Val Thr Ser Val Ser Thr Leu Lys Ser Glu 
        115                 120                 125             


Asp Ile Lys Ile Arg Gln Asp Ser Val Thr Lys Leu Leu Thr Asp Val 
    130                 135                 140                 


Gln Leu Met Lys Gly Lys Gln Glu Cys Met Asp Ser Lys Leu Leu Ala 
145                 150                 155                 160 


Met Lys His Glu Asn Glu Ala Leu Trp Arg Glu Val Ala Ser Leu Arg 
                165                 170                 175     


Gln Lys His Ala Gln Gln Gln Lys Val Val Asn Lys Leu Ile Gln Phe 
            180                 185                 190         


Leu Ile Ser Leu Val Gln Ser Asn Arg Ile Leu Gly Val Lys Arg Lys 
        195                 200                 205             


Ile Pro Leu Met Leu Asn Asp Ser Gly Ser Ala His Ser Met Pro Lys 
    210                 215                 220                 


Tyr Ser Arg Gln Phe Ser Leu Glu His Val His Gly Ser Gly Pro Tyr 
225                 230                 235                 240 


Ser Ala Pro Ser Pro Ala Tyr Ser Ser Ser Ser Leu Tyr Ala Pro Asp 
                245                 250                 255     


Ala Val Ala Ser Ser Gly Pro Ile Ile Ser Asp Ile Thr Glu Leu Ala 
            260                 265                 270         


Pro Ala Ser Pro Met Ala Ser Pro Gly Gly Ser Ile Asp Glu Arg Pro 
        275                 280                 285             


Leu Ser Ser Ser Pro Leu Val Arg Val Lys Glu Glu Pro Pro Ser Pro 
    290                 295                 300                 


Pro Gln Ser Pro Arg Val Glu Glu Ala Ser Pro Gly Arg Pro Ser Ser 
305                 310                 315                 320 


Val Asp Thr Leu Leu Ser Pro Thr Ala Leu Ile Asp Ser Ile Leu Arg 
                325                 330                 335     


Glu Ser Glu Pro Ala Pro Ala Ser Val Thr Ala Leu Thr Asp Ala Arg 
            340                 345                 350         


Gly His Thr Asp Thr Glu Gly Arg Pro Pro Ser Pro Pro Pro Thr Ser 
        355                 360                 365             


Thr Pro Glu Lys Cys Leu Ser Val Ala Cys Leu Asp Lys Asn Glu Leu 
    370                 375                 380                 


Ser Asp His Leu Asp Ala Met Asp Ser Asn Leu Asp Asn Leu Gln Thr 
385                 390                 395                 400 


Met Leu Ser Ser His Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp 
                405                 410                 415     


Leu Phe Ser Pro Ser Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu 
            420                 425                 430         


Asp Ser Ser Leu Ala Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro 
        435                 440                 445             


Pro Arg Pro Pro Glu Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln 
    450                 455                 460                 


Leu Val His Tyr Thr Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser 
465                 470                 475                 480 


Val Asp Thr Gly Ser Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu 
                485                 490                 495     


Gly Ser Tyr Phe Ser Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile 
            500                 505                 510         


Ser Leu Leu Thr Gly Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val 
        515                 520                 525             


Ser 
    


<210>  5199
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSF2__Homo_sapiens__NP_001129036

<400>  5199

Met Lys Gln Ser Ser Asn Val Pro Ala Phe Leu Ser Lys Leu Trp Thr 
1               5                   10                  15      


Leu Val Glu Glu Thr His Thr Asn Glu Phe Ile Thr Trp Ser Gln Asn 
            20                  25                  30          


Gly Gln Ser Phe Leu Val Leu Asp Glu Gln Arg Phe Ala Lys Glu Ile 
        35                  40                  45              


Leu Pro Lys Tyr Phe Lys His Asn Asn Met Ala Ser Phe Val Arg Gln 
    50                  55                  60                  


Leu Asn Met Tyr Gly Phe Arg Lys Val Val His Ile Asp Ser Gly Ile 
65                  70                  75                  80  


Val Lys Gln Glu Arg Asp Gly Pro Val Glu Phe Gln His Pro Tyr Phe 
                85                  90                  95      


Lys Gln Gly Gln Asp Asp Leu Leu Glu Asn Ile Lys Arg Lys Val Ser 
            100                 105                 110         


Ser Ser Lys Pro Glu Glu Asn Lys Ile Arg Gln Glu Asp Leu Thr Lys 
        115                 120                 125             


Ile Ile Ser Ser Ala Gln Lys Val Gln Ile Lys Gln Glu Thr Ile Glu 
    130                 135                 140                 


Ser Arg Leu Ser Glu Leu Lys Ser Glu Asn Glu Ser Leu Trp Lys Glu 
145                 150                 155                 160 


Val Ser Glu Leu Arg Ala Lys His Ala Gln Gln Gln Gln Val Ile Arg 
                165                 170                 175     


Lys Ile Val Gln Phe Ile Val Thr Leu Val Gln Asn Asn Gln Leu Val 
            180                 185                 190         


Ser Leu Lys Arg Lys Arg Pro Leu Leu Leu Asn Thr Asn Gly Ala Gln 
        195                 200                 205             


Lys Lys Asn Leu Phe Gln His Ile Val Lys Glu Pro Thr Asp Asn His 
    210                 215                 220                 


His His Lys Val Pro His Ser Arg Thr Glu Gly Leu Lys Pro Arg Glu 
225                 230                 235                 240 


Arg Ile Ser Asp Asp Ile Ile Ile Tyr Asp Val Thr Asp Asp Asn Ala 
                245                 250                 255     


Asp Glu Glu Asn Ile Pro Val Ile Pro Glu Thr Asn Glu Asp Val Ile 
            260                 265                 270         


Ser Asp Pro Ser Asn Cys Ser Gln Tyr Pro Asp Ile Val Ile Val Glu 
        275                 280                 285             


Asp Asp Asn Glu Asp Glu Tyr Ala Pro Val Ile Gln Ser Gly Glu Gln 
    290                 295                 300                 


Asn Glu Pro Ala Arg Glu Ser Leu Ser Ser Gly Ser Asp Gly Ser Ser 
305                 310                 315                 320 


Pro Leu Met Ser Ser Ala Val Gln Leu Asn Gly Ser Ser Ser Leu Thr 
                325                 330                 335     


Ser Glu Asp Pro Val Thr Met Met Asp Ser Ile Leu Asn Asp Asn Ile 
            340                 345                 350         


Asn Leu Leu Gly Lys Val Glu Leu Leu Asp Tyr Leu Asp Ser Ile Asp 
        355                 360                 365             


Cys Ser Leu Glu Asp Phe Gln Ala Met Leu Ser Gly Arg Gln Phe Ser 
    370                 375                 380                 


Ile Asp Pro Asp Leu Leu Val Asp Ser Glu Asn Lys Gly Leu Glu Thr 
385                 390                 395                 400 


Thr Lys Asn Asn Val Val Gln Pro Val Ser Glu Glu Gly Arg Lys Ser 
                405                 410                 415     


Lys Ser Lys Pro Asp Lys Gln Leu Ile Gln Tyr Thr Ala Phe Pro Leu 
            420                 425                 430         


Leu Ala Phe Leu Asp Gly Asn Pro Ala Ser Ser Val Glu Gln Ala Ser 
        435                 440                 445             


Thr Thr Ala Ser Ser Glu Val Leu Ser Ser Val Asp Lys Pro Ile Glu 
    450                 455                 460                 


Val Asp Glu Leu Leu Asp Ser Ser Leu Asp Pro Glu Pro Thr Gln Ser 
465                 470                 475                 480 


Lys Leu Val Arg Leu Glu Pro Leu Thr Glu Ala Glu Ala Ser Glu Ala 
                485                 490                 495     


Thr Leu Phe Tyr Leu Cys Glu Leu Ala Pro Ala Pro Leu Asp Ser Asp 
            500                 505                 510         


Met Pro Leu Leu Asp Ser 
        515             


<210>  5200
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSF4__Homo_sapiens__NP_001035757

<400>  5200

Met Gln Glu Ala Pro Ala Ala Leu Pro Thr Glu Pro Gly Pro Ser Pro 
1               5                   10                  15      


Val Pro Ala Phe Leu Gly Lys Leu Trp Ala Leu Val Gly Asp Pro Gly 
            20                  25                  30          


Thr Asp His Leu Ile Arg Trp Ser Pro Ser Gly Thr Ser Phe Leu Val 
        35                  40                  45              


Ser Asp Gln Ser Arg Phe Ala Lys Glu Val Leu Pro Gln Tyr Phe Lys 
    50                  55                  60                  


His Ser Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe 
65                  70                  75                  80  


Arg Lys Val Val Ser Ile Glu Gln Gly Gly Leu Leu Arg Pro Glu Arg 
                85                  90                  95      


Asp His Val Glu Phe Gln His Pro Ser Phe Val Arg Gly Arg Glu Gln 
            100                 105                 110         


Leu Leu Glu Arg Val Arg Arg Lys Val Pro Ala Leu Arg Gly Asp Asp 
        115                 120                 125             


Gly Arg Trp Arg Pro Glu Asp Leu Gly Arg Leu Leu Gly Glu Val Gln 
    130                 135                 140                 


Ala Leu Arg Gly Val Gln Glu Ser Thr Glu Ala Arg Leu Arg Glu Leu 
145                 150                 155                 160 


Arg Gln Gln Asn Glu Ile Leu Trp Arg Glu Val Val Thr Leu Arg Gln 
                165                 170                 175     


Ser His Gly Gln Gln His Arg Val Ile Gly Lys Leu Ile Gln Cys Leu 
            180                 185                 190         


Phe Gly Pro Leu Gln Ala Gly Pro Ser Asn Ala Gly Gly Lys Arg Lys 
        195                 200                 205             


Leu Ser Leu Met Leu Asp Glu Gly Ser Ser Cys Pro Thr Pro Ala Lys 
    210                 215                 220                 


Phe Asn Thr Cys Pro Leu Pro Gly Ala Leu Leu Gln Asp Pro Tyr Phe 
225                 230                 235                 240 


Ile Gln Ser Pro Leu Pro Glu Thr Asn Leu Gly Leu Ser Pro His Arg 
                245                 250                 255     


Ala Arg Gly Pro Ile Ile Ser Asp Ile Pro Glu Asp Ser Pro Ser Pro 
            260                 265                 270         


Glu Gly Thr Arg Leu Ser Pro Ser Ser Asp Gly Arg Arg Glu Lys Gly 
        275                 280                 285             


Leu Ala Leu Leu Lys Glu Glu Pro Ala Ser Pro Gly Gly Asp Gly Glu 
    290                 295                 300                 


Ala Gly Leu Ala Leu Ala Pro Asn Glu Cys Asp Phe Cys Val Thr Ala 
305                 310                 315                 320 


Pro Pro Pro Leu Pro Val Ala Val Val Gln Ala Ile Leu Glu Gly Lys 
                325                 330                 335     


Gly Ser Phe Ser Pro Glu Gly Pro Arg Asn Ala Gln Gln Pro Glu Pro 
            340                 345                 350         


Gly Asp Pro Arg Glu Ile Pro Asp Arg Gly Pro Leu Gly Leu Glu Ser 
        355                 360                 365             


Gly Asp Arg Ser Pro Glu Ser Leu Leu Pro Pro Met Leu Leu Gln Pro 
    370                 375                 380                 


Pro Gln Glu Ser Val Glu Pro Ala Gly Pro Leu Asp Val Leu Gly Pro 
385                 390                 395                 400 


Ser Leu Gln Gly Arg Glu Trp Thr Leu Met Asp Leu Asp Met Glu Leu 
                405                 410                 415     


Ser Leu Met Gln Pro Leu Val Pro Glu Arg Gly Glu Pro Glu Leu Ala 
            420                 425                 430         


Val Lys Gly Leu Asn Ser Pro Ser Pro Gly Lys Asp Pro Thr Leu Gly 
        435                 440                 445             


Ala Pro Leu Leu Leu Asp Val Gln Ala Ala Leu Gly Gly Pro Ala Leu 
    450                 455                 460                 


Gly Leu Pro Gly Ala Leu Thr Ile Tyr Ser Thr Pro Glu Ser Arg Thr 
465                 470                 475                 480 


Ala Ser Tyr Leu Gly Pro Glu Ala Ser Pro Ser Pro 
                485                 490         


<210>  5201
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSF5__Homo_sapiens__NP_001073908

<400>  5201

Met Glu Ala Leu Leu Ser Thr Pro Ile Asn Pro Asn Asn Phe Pro Ala 
1               5                   10                  15      


Lys Leu Trp Arg Leu Val Asn Ser Pro Arg Tyr Arg Ser Ile Arg Trp 
            20                  25                  30          


Asp Gly Arg Gly Glu Gly Leu Leu Ile Asp Gln Pro Leu Phe Glu Ala 
        35                  40                  45              


Glu Leu Leu Ser Pro Pro Gly Pro Gly Gly Gly Gly Gly Thr Ala Gly 
    50                  55                  60                  


Ala Gly Ala Glu Pro Glu Leu Phe Lys Thr Thr Ser Phe Thr Ser Phe 
65                  70                  75                  80  


Ile Arg Gln Leu Asn Leu Tyr Gly Phe Arg Lys Val Val Leu Gly Gly 
                85                  90                  95      


Pro Gly Gly Gly Lys Pro Ala Gly Asn Gly Pro Leu His His Phe His 
            100                 105                 110         


Asn Pro His Phe Arg Arg Asp Gln Pro Gln Leu Leu Val His Leu Lys 
        115                 120                 125             


Arg Leu Thr Ser Ala Asn Lys Ala Lys Leu Ala Ala Gly Leu Glu Val 
    130                 135                 140                 


Pro Cys Arg Pro Pro Asn Arg Phe Gln Arg Leu Leu Ile Thr Ser Ala 
145                 150                 155                 160 


Ser Ala Ala Thr Ala Pro Leu Gln His Gln Gln Pro Pro Pro Pro Ala 
                165                 170                 175     


Gly Pro Arg Pro Glu Pro His Gly Pro Val Ala Val Gly Gln Phe His 
            180                 185                 190         


Arg Ser Phe Arg Arg Asp Ser Leu Ser Pro Tyr Ser Cys Val Ser Thr 
        195                 200                 205             


Pro Ser His Asp His Ser Thr Tyr Pro Leu Lys Gly Leu Asp Arg Thr 
    210                 215                 220                 


Pro Val Pro His Arg Ile Trp Gln Asn Ser Leu Gly Met His Pro Gly 
225                 230                 235                 240 


Gln Val Glu Thr Ser Pro Thr Phe Ser Asp Lys Gly Val Pro Phe Pro 
                245                 250                 255     


Val Leu Gln Arg Phe Pro Thr Glu Val Thr Tyr Thr Leu Gln Pro Ser 
            260                 265                 270         


Thr Thr Ser Val His Val Gln Gln Gly Pro Gln Thr Met Val Ser Ser 
        275                 280                 285             


Ser Gln Lys Tyr Ser Asn Tyr Thr Pro Ser Ala Gln Tyr Ser Gln Ala 
    290                 295                 300                 


Tyr Tyr Pro Thr Ala Val Leu Gln Cys Cys Ser Pro Thr His Met Asp 
305                 310                 315                 320 


Ala Leu Ser Ser Cys Val Thr Pro Thr Ala Ser Ser Tyr Ala His Cys 
                325                 330                 335     


Asn Tyr Phe Gln Asn Pro Ser Met Gln Ser Ser Tyr Pro Val Glu Phe 
            340                 345                 350         


Leu Pro Ser Asn Trp Pro Cys Ser Thr Thr Asp Glu Asn Thr Lys Thr 
        355                 360                 365             


Glu Val Asn Leu Glu Ala Val Phe Gln Ile Val Asp Glu Leu His Ser 
    370                 375                 380                 


Ser Pro Lys Leu Glu Met Val Lys Val Glu Pro Val Glu Asn Gln Cys 
385                 390                 395                 400 


Pro Thr Ser Pro Ser Tyr Arg Gly Gln His Ile Leu Ala Asn Ser Asn 
                405                 410                 415     


Asn Ser Asn Pro Cys Ser Ala Ser Gln Ala Ser Gln Leu Glu Pro Leu 
            420                 425                 430         


Thr Pro Val Gly Ser Asp Ile Met Ser Phe Val Val Gly Thr Glu Gln 
        435                 440                 445             


Ala Val Ala Cys Ser Leu Pro Gln Ser Pro Glu Tyr Ile Tyr Thr Ile 
    450                 455                 460                 


His Thr Ala Gln Pro Val Glu Asn Ser Thr Ile Gln Glu Ser Ala Ala 
465                 470                 475                 480 


Ile Gln Gln Ala His Val Lys Leu Lys Glu His Leu Asn His Asn Pro 
                485                 490                 495     


Ser Pro Ser Ser Val Val Phe Val Gln Glu Gly Pro Pro Phe Ser Thr 
            500                 505                 510         


His Gln Val Asp Ala Asn Ile Lys Cys Gln Thr Ser Ser Arg Glu Asn 
        515                 520                 525             


Ile Leu Pro Ser Glu Gln Met Gly Phe Leu Ile Ser Glu Met Gly Pro 
    530                 535                 540                 


Ala Ser Lys Pro Ser Glu Asp Thr Gly Leu Ala Thr Pro Ala Arg Tyr 
545                 550                 555                 560 


Arg Glu His Arg Ser Asn Ser Gln Gln Gly Lys Ser Pro Asp Leu His 
                565                 570                 575     


Leu Leu Val Asp Val Ala Cys Lys Gln Glu Arg Phe Pro Lys Glu Glu 
            580                 585                 590         


Glu Leu Lys Glu 
        595     


<210>  5202
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSFY2__Homo_sapiens__NP_001001877

<400>  5202

Met Ala His Val Ser Ser Glu Thr Gln Asp Val Ser Pro Lys Asp Glu 
1               5                   10                  15      


Leu Thr Ala Ser Glu Ala Ser Thr Arg Ser Pro Leu Cys Glu His Thr 
            20                  25                  30          


Phe Pro Gly Asp Ser Asp Leu Arg Ser Met Ile Glu Glu His Ala Phe 
        35                  40                  45              


Gln Val Leu Ser Gln Gly Ser Leu Leu Glu Ser Pro Ser Tyr Thr Val 
    50                  55                  60                  


Cys Val Ser Glu Pro Asp Lys Asp Asp Asp Phe Leu Ser Leu Asn Phe 
65                  70                  75                  80  


Pro Arg Lys Leu Trp Lys Ile Val Glu Ser Asp Gln Phe Lys Ser Ile 
                85                  90                  95      


Ser Trp Asp Glu Asn Gly Thr Cys Ile Val Ile Asn Glu Glu Leu Phe 
            100                 105                 110         


Lys Lys Glu Ile Leu Glu Thr Lys Ala Pro Tyr Arg Ile Phe Gln Thr 
        115                 120                 125             


Asp Ala Ile Lys Ser Phe Val Arg Gln Leu Asn Leu Tyr Gly Phe Ser 
    130                 135                 140                 


Lys Ile Gln Gln Asn Phe Gln Arg Ser Ala Phe Leu Ala Thr Phe Leu 
145                 150                 155                 160 


Ser Glu Glu Lys Glu Ser Ser Val Leu Ser Lys Ile Arg Phe Thr Lys 
                165                 170                 175     


Met Lys Leu Ser Arg Ser Ser Thr Tyr Glu Asn Arg Tyr Leu Cys Cys 
            180                 185                 190         


Asn Leu His Leu Lys Asp Glu Ser Asn Tyr Ser 
        195                 200             


<210>  5203
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSH2D__Homo_sapiens__NP_001278203

<400>  5203

Met Arg Gly Ser Arg Met Ser Gln Pro Pro Gln Cys Leu Arg Arg Ala 
1               5                   10                  15      


Gln Ser Ser Cys Cys His Phe Met Val Lys Leu Leu Asp Asp Gly Thr 
            20                  25                  30          


Phe Met Ile Pro Gly Glu Lys Val Ala His Thr Ser Leu Asp Ala Leu 
        35                  40                  45              


Val Thr Phe His Gln Gln Lys Pro Ile Glu Pro Arg Arg Glu Leu Leu 
    50                  55                  60                  


Thr Gln Pro Cys Arg Gln Lys Asp Pro Ala Asn Val Asp Tyr Glu Asp 
65                  70                  75                  80  


Leu Phe Leu Tyr Ser Asn Ala Val Ala Glu Glu Ala Ala Cys Pro Val 
                85                  90                  95      


Ser Ala Pro Glu Glu Ala Ser Pro Lys Pro Val Leu Cys His Gln Ser 
            100                 105                 110         


Lys Glu Arg Lys Pro Ser Ala Glu Met Asn Arg Ile Thr Thr Lys Glu 
        115                 120                 125             


Ala Thr Ser Ser Cys Pro Pro Lys Ser Pro Leu Gly Glu Thr Arg Gln 
    130                 135                 140                 


Lys Leu Trp Arg Ser Leu Lys Met Leu Pro Glu Arg Gly Gln Arg Val 
145                 150                 155                 160 


Arg Gln Gln Leu Lys Ser His Leu Ala Thr Val Asn Leu Ser Ser Leu 
                165                 170                 175     


Leu Asp Val Arg Arg Ser Thr Val Ile Ser Gly Pro Gly Thr Gly Lys 
            180                 185                 190         


Gly Ser Gln Asp His Ser Gly Asp Pro Thr Ser Gly Asp Arg Gly Tyr 
        195                 200                 205             


Thr Asp Pro Cys Val Ala Thr Ser Leu Lys Ser Pro Ser Gln Pro Gln 
    210                 215                 220                 


Ala Pro Lys Asp Arg Lys Val Pro Thr Arg Lys Ala Glu Arg Ser Val 
225                 230                 235                 240 


Ser Cys Ile Glu Val Thr Pro Gly Asp Arg Ser Trp His Gln Met Val 
                245                 250                 255     


Val Arg Ala Leu Ser Ser Gln Glu Ser Lys Pro Glu His Gln Gly Leu 
            260                 265                 270         


Ala Glu Pro Glu Asn Asp Gln Leu Pro Glu Glu Tyr Gln Gln Pro Pro 
        275                 280                 285             


Pro Phe Ala Pro Gly Tyr Cys 
    290                 295 


<210>  5204
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSP90AA1__Homo_sapiens__NP_001017963

<400>  5204

Met Pro Pro Cys Ser Gly Gly Asp Gly Ser Thr Pro Pro Gly Pro Ser 
1               5                   10                  15      


Leu Arg Asp Arg Asp Cys Pro Ala Gln Ser Ala Glu Tyr Pro Arg Asp 
            20                  25                  30          


Arg Leu Asp Pro Arg Pro Gly Ser Pro Ser Glu Ala Ser Ser Pro Pro 
        35                  40                  45              


Phe Leu Arg Ser Arg Ala Pro Val Asn Trp Tyr Gln Glu Lys Ala Gln 
    50                  55                  60                  


Val Phe Leu Trp His Leu Met Val Ser Gly Ser Thr Thr Leu Leu Cys 
65                  70                  75                  80  


Leu Trp Lys Gln Pro Phe His Val Ser Ala Phe Pro Val Thr Ala Ser 
                85                  90                  95      


Leu Ala Phe Arg Gln Ser Gln Gly Ala Gly Gln His Leu Tyr Lys Asp 
            100                 105                 110         


Leu Gln Pro Phe Ile Leu Leu Arg Leu Leu Met Pro Glu Glu Thr Gln 
        115                 120                 125             


Thr Gln Asp Gln Pro Met Glu Glu Glu Glu Val Glu Thr Phe Ala Phe 
    130                 135                 140                 


Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe Tyr 
145                 150                 155                 160 


Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ser Ser Asp 
                165                 170                 175     


Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys Leu 
            180                 185                 190         


Asp Ser Gly Lys Glu Leu His Ile Asn Leu Ile Pro Asn Lys Gln Asp 
        195                 200                 205             


Arg Thr Leu Thr Ile Val Asp Thr Gly Ile Gly Met Thr Lys Ala Asp 
    210                 215                 220                 


Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala Phe 
225                 230                 235                 240 


Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln Phe 
                245                 250                 255     


Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Thr Val 
            260                 265                 270         


Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser Ala 
        275                 280                 285             


Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly Glu Pro Met Gly Arg 
    290                 295                 300                 


Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr Leu 
305                 310                 315                 320 


Glu Glu Arg Arg Ile Lys Glu Ile Val Lys Lys His Ser Gln Phe Ile 
                325                 330                 335     


Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu Arg Asp Lys Glu Val 
            340                 345                 350         


Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys Glu 
        355                 360                 365             


Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro Glu Ile Glu Asp Val Gly 
    370                 375                 380                 


Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys Lys 
385                 390                 395                 400 


Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys 
                405                 410                 415     


Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly 
            420                 425                 430         


Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val 
        435                 440                 445             


Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe 
    450                 455                 460                 


Val Pro Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Arg Lys Lys Lys 
465                 470                 475                 480 


Asn Asn Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Asn Cys 
                485                 490                 495     


Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp 
            500                 505                 510         


Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser 
        515                 520                 525             


Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val Lys Lys Cys Leu Glu 
    530                 535                 540                 


Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr 
545                 550                 555                 560 


Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile His Glu Asp Ser Gln 
                565                 570                 575     


Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr Tyr Thr Ser Ala Ser 
            580                 585                 590         


Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr Arg Met Lys Glu 
        595                 600                 605             


Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr Lys Asp Gln Val 
    610                 615                 620                 


Ala Asn Ser Ala Phe Val Glu Arg Leu Arg Lys His Gly Leu Glu Val 
625                 630                 635                 640 


Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys 
                645                 650                 655     


Glu Phe Glu Gly Lys Thr Leu Val Ser Val Thr Lys Glu Gly Leu Glu 
            660                 665                 670         


Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys Gln Glu Glu Lys Lys Thr 
        675                 680                 685             


Lys Phe Glu Asn Leu Cys Lys Ile Met Lys Asp Ile Leu Glu Lys Lys 
    690                 695                 700                 


Val Glu Lys Val Val Val Ser Asn Arg Leu Val Thr Ser Pro Cys Cys 
705                 710                 715                 720 


Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met 
                725                 730                 735     


Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Ala Ala 
            740                 745                 750         


Lys Lys His Leu Glu Ile Asn Pro Asp His Ser Ile Ile Glu Thr Leu 
        755                 760                 765             


Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp Lys Ser Val Lys Asp Leu 
    770                 775                 780                 


Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu 
785                 790                 795                 800 


Glu Asp Pro Gln Thr His Ala Asn Arg Ile Tyr Arg Met Ile Lys Leu 
                805                 810                 815     


Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr Ala Asp Asp Thr Ser Ala 
            820                 825                 830         


Ala Val Thr Glu Glu Met Pro Pro Leu Glu Gly Asp Asp Asp Thr Ser 
        835                 840                 845             


Arg Met Glu Glu Val Asp 
    850                 


<210>  5205
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSP90AB1__Homo_sapiens__NP_001258898

<400>  5205

Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210>  5206
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSP90B1__Homo_sapiens__NP_003290

<400>  5206

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  5207
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA12A__Homo_sapiens__NP_079291

<400>  5207

Met Ala Asp Lys Glu Ala Gly Gly Ser Asp Gly Pro Arg Glu Thr Ala 
1               5                   10                  15      


Pro Thr Ser Ala Tyr Ser Ser Pro Ala Arg Ser Leu Gly Asp Thr Gly 
            20                  25                  30          


Ile Thr Pro Leu Ser Pro Ser His Ile Val Asn Asp Thr Asp Ser Asn 
        35                  40                  45              


Val Ser Glu Gln Gln Ser Phe Leu Val Val Val Ala Val Asp Phe Gly 
    50                  55                  60                  


Thr Thr Ser Ser Gly Tyr Ala Tyr Ser Phe Thr Lys Glu Pro Glu Cys 
65                  70                  75                  80  


Ile His Val Met Arg Arg Trp Glu Gly Gly Asp Pro Gly Val Ser Asn 
                85                  90                  95      


Gln Lys Thr Pro Thr Thr Ile Leu Leu Thr Pro Glu Arg Lys Phe His 
            100                 105                 110         


Ser Phe Gly Tyr Ala Ala Arg Asp Phe Tyr His Asp Leu Asp Pro Asn 
        115                 120                 125             


Glu Ala Lys Gln Trp Leu Tyr Leu Glu Lys Phe Lys Met Lys Leu His 
    130                 135                 140                 


Thr Thr Gly Asp Leu Thr Met Asp Thr Asp Leu Thr Ala Ala Asn Gly 
145                 150                 155                 160 


Lys Lys Val Lys Ala Leu Glu Ile Phe Ala Tyr Ala Leu Gln Tyr Phe 
                165                 170                 175     


Lys Glu Gln Ala Leu Lys Glu Leu Ser Asp Gln Ala Gly Ser Glu Phe 
            180                 185                 190         


Glu Asn Ser Asp Val Arg Trp Val Ile Thr Val Pro Ala Ile Trp Lys 
        195                 200                 205             


Gln Pro Ala Lys Gln Phe Met Arg Gln Ala Ala Tyr Gln Ala Gly Leu 
    210                 215                 220                 


Ala Ser Pro Glu Asn Ser Glu Gln Leu Ile Ile Ala Leu Glu Pro Glu 
225                 230                 235                 240 


Ala Ala Ser Ile Tyr Cys Arg Lys Leu Arg Leu His Gln Met Ile Glu 
                245                 250                 255     


Leu Ser Ser Lys Ala Ala Val Asn Gly Tyr Ser Gly Ser Asp Thr Val 
            260                 265                 270         


Gly Ala Gly Phe Thr Gln Ala Lys Glu His Ile Arg Arg Asn Arg Gln 
        275                 280                 285             


Ser Arg Thr Phe Leu Val Glu Asn Val Ile Gly Glu Ile Trp Ser Glu 
    290                 295                 300                 


Leu Glu Glu Gly Asp Lys Tyr Val Val Val Asp Ser Gly Gly Gly Thr 
305                 310                 315                 320 


Val Asp Leu Thr Val His Gln Ile Arg Leu Pro Glu Gly His Leu Lys 
                325                 330                 335     


Glu Leu Tyr Lys Ala Thr Gly Gly Pro Tyr Gly Ser Leu Gly Val Asp 
            340                 345                 350         


Tyr Glu Phe Glu Lys Leu Leu Tyr Lys Ile Phe Gly Glu Asp Phe Ile 
        355                 360                 365             


Glu Gln Phe Lys Ile Lys Arg Pro Ala Ala Trp Val Asp Leu Met Ile 
    370                 375                 380                 


Ala Phe Glu Ser Arg Lys Arg Ala Ala Ala Pro Asp Arg Thr Asn Pro 
385                 390                 395                 400 


Leu Asn Ile Thr Leu Pro Phe Ser Phe Ile Asp Tyr Tyr Lys Lys Phe 
                405                 410                 415     


Arg Gly His Ser Val Glu His Ala Leu Arg Lys Ser Asn Val Asp Phe 
            420                 425                 430         


Val Lys Trp Ser Ser Gln Gly Met Leu Arg Met Ser Pro Asp Ala Met 
        435                 440                 445             


Asn Ala Leu Phe Lys Pro Thr Ile Asp Ser Ile Ile Glu His Leu Arg 
    450                 455                 460                 


Asp Leu Phe Gln Lys Pro Glu Val Ser Thr Val Lys Phe Leu Phe Leu 
465                 470                 475                 480 


Val Gly Gly Phe Ala Glu Ala Pro Leu Leu Gln Gln Ala Val Gln Ala 
                485                 490                 495     


Ala Phe Gly Asp Gln Cys Arg Ile Ile Ile Pro Gln Asp Val Gly Leu 
            500                 505                 510         


Thr Ile Leu Lys Gly Ala Val Leu Phe Gly Leu Asp Pro Ala Val Ile 
        515                 520                 525             


Lys Val Arg Arg Ser Pro Leu Thr Tyr Gly Val Gly Val Leu Asn Arg 
    530                 535                 540                 


Tyr Val Glu Gly Lys His Pro Pro Glu Lys Leu Leu Val Lys Asp Gly 
545                 550                 555                 560 


Thr Arg Trp Cys Thr Asp Val Phe Asp Lys Phe Ile Ser Ala Asp Gln 
                565                 570                 575     


Ser Val Ala Leu Gly Glu Leu Val Lys Arg Ser Tyr Thr Pro Ala Lys 
            580                 585                 590         


Pro Ser Gln Leu Val Ile Val Ile Asn Ile Tyr Ser Ser Glu His Asp 
        595                 600                 605             


Asn Val Ser Phe Ile Thr Asp Pro Gly Val Lys Lys Cys Gly Thr Leu 
    610                 615                 620                 


Arg Leu Asp Leu Thr Gly Thr Ser Gly Thr Ala Val Pro Ala Arg Arg 
625                 630                 635                 640 


Glu Ile Gln Thr Leu Met Gln Phe Gly Asp Thr Glu Ile Lys Ala Thr 
                645                 650                 655     


Ala Ile Asp Ile Ala Thr Ser Lys Ser Val Lys Val Gly Ile Asp Phe 
            660                 665                 670         


Leu Asn Tyr 
        675 


<210>  5208
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA12B__Homo_sapiens__NP_443202

<400>  5208

Met Leu Ala Val Pro Glu Met Gly Leu Gln Gly Leu Tyr Ile Gly Ser 
1               5                   10                  15      


Ser Pro Glu Arg Ser Pro Val Pro Ser Pro Pro Gly Ser Pro Arg Thr 
            20                  25                  30          


Gln Glu Ser Cys Gly Ile Ala Pro Leu Thr Pro Ser Gln Ser Pro Lys 
        35                  40                  45              


Pro Glu Val Arg Ala Pro Gln Gln Ala Ser Phe Ser Val Val Val Ala 
    50                  55                  60                  


Ile Asp Phe Gly Thr Thr Ser Ser Gly Tyr Ala Phe Ser Phe Ala Ser 
65                  70                  75                  80  


Asp Pro Glu Ala Ile His Met Met Arg Lys Trp Glu Gly Gly Asp Pro 
                85                  90                  95      


Gly Val Ala His Gln Lys Thr Pro Thr Cys Leu Leu Leu Thr Pro Glu 
            100                 105                 110         


Gly Ala Phe His Ser Phe Gly Tyr Thr Ala Arg Asp Tyr Tyr His Asp 
        115                 120                 125             


Leu Asp Pro Glu Glu Ala Arg Asp Trp Leu Tyr Phe Glu Lys Phe Lys 
    130                 135                 140                 


Met Lys Ile His Ser Ala Thr Asp Leu Thr Leu Lys Thr Gln Leu Glu 
145                 150                 155                 160 


Ala Val Asn Gly Lys Thr Met Pro Ala Leu Glu Val Phe Ala His Ala 
                165                 170                 175     


Leu Arg Phe Phe Arg Glu His Ala Leu Gln Glu Leu Arg Glu Gln Ser 
            180                 185                 190         


Pro Ser Leu Pro Glu Lys Asp Thr Val Arg Trp Val Leu Thr Val Pro 
        195                 200                 205             


Ala Ile Trp Lys Gln Pro Ala Lys Gln Phe Met Arg Glu Ala Ala Tyr 
    210                 215                 220                 


Leu Ala Gly Leu Val Ser Arg Glu Asn Ala Glu Gln Leu Leu Ile Ala 
225                 230                 235                 240 


Leu Glu Pro Glu Ala Ala Ser Val Tyr Cys Arg Lys Leu Arg Leu His 
                245                 250                 255     


Gln Leu Leu Asp Leu Ser Gly Arg Ala Pro Gly Gly Gly Arg Leu Gly 
            260                 265                 270         


Glu Arg Arg Ser Ile Asp Ser Ser Phe Arg Gln Ala Arg Glu Gln Leu 
        275                 280                 285             


Arg Arg Ser Arg His Ser Arg Thr Phe Leu Val Glu Ser Gly Val Gly 
    290                 295                 300                 


Glu Leu Trp Ala Glu Met Gln Ala Gly Asp Arg Tyr Val Val Ala Asp 
305                 310                 315                 320 


Cys Gly Gly Gly Thr Val Asp Leu Thr Val His Gln Leu Glu Gln Pro 
                325                 330                 335     


His Gly Thr Leu Lys Glu Leu Tyr Lys Ala Ser Gly Gly Pro Tyr Gly 
            340                 345                 350         


Ala Val Gly Val Asp Leu Ala Phe Glu Gln Leu Leu Cys Arg Ile Phe 
        355                 360                 365             


Gly Glu Asp Phe Ile Ala Thr Phe Lys Arg Gln Arg Pro Ala Ala Trp 
    370                 375                 380                 


Val Asp Leu Thr Ile Ala Phe Glu Ala Arg Lys Arg Thr Ala Gly Pro 
385                 390                 395                 400 


His Arg Ala Gly Ala Leu Asn Ile Ser Leu Pro Phe Ser Phe Ile Asp 
                405                 410                 415     


Phe Tyr Arg Lys Gln Arg Gly His Asn Val Glu Thr Ala Leu Arg Arg 
            420                 425                 430         


Ser Ser Val Asn Phe Val Lys Trp Ser Ser Gln Gly Met Leu Arg Met 
        435                 440                 445             


Ser Cys Glu Ala Met Asn Glu Leu Phe Gln Pro Thr Val Ser Gly Ile 
    450                 455                 460                 


Ile Gln His Ile Glu Ala Leu Leu Ala Arg Pro Glu Val Gln Gly Val 
465                 470                 475                 480 


Lys Leu Leu Phe Leu Val Gly Gly Phe Ala Glu Ser Ala Val Leu Gln 
                485                 490                 495     


His Ala Val Gln Ala Ala Leu Gly Ala Arg Gly Leu Arg Val Val Val 
            500                 505                 510         


Pro His Asp Val Gly Leu Thr Ile Leu Lys Gly Ala Val Leu Phe Gly 
        515                 520                 525             


Gln Ala Pro Gly Val Val Arg Val Arg Arg Ser Pro Leu Thr Tyr Gly 
    530                 535                 540                 


Val Gly Val Leu Asn Arg Phe Val Pro Gly Arg His Pro Pro Glu Lys 
545                 550                 555                 560 


Leu Leu Val Arg Asp Gly Arg Arg Trp Cys Thr Asp Val Phe Glu Arg 
                565                 570                 575     


Phe Val Ala Ala Glu Gln Ser Val Ala Leu Gly Glu Glu Val Arg Arg 
            580                 585                 590         


Ser Tyr Cys Pro Ala Arg Pro Gly Gln Arg Arg Val Leu Ile Asn Leu 
        595                 600                 605             


Tyr Cys Cys Ala Ala Glu Asp Ala Arg Phe Ile Thr Asp Pro Gly Val 
    610                 615                 620                 


Arg Lys Cys Gly Ala Leu Ser Leu Glu Leu Glu Pro Ala Asp Cys Gly 
625                 630                 635                 640 


Gln Asp Thr Ala Gly Ala Pro Pro Gly Arg Arg Glu Ile Arg Ala Ala 
                645                 650                 655     


Met Gln Phe Gly Asp Thr Glu Ile Lys Val Thr Ala Val Asp Val Ser 
            660                 665                 670         


Thr Asn Arg Ser Val Arg Ala Ser Ile Asp Phe Leu Ser Asn 
        675                 680                 685     


<210>  5209
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA13__Homo_sapiens__NP_008879

<400>  5209

Met Ala Arg Glu Met Thr Ile Leu Gly Ser Ala Val Leu Thr Leu Leu 
1               5                   10                  15      


Leu Ala Gly Tyr Leu Ala Gln Gln Tyr Leu Pro Leu Pro Thr Pro Lys 
            20                  25                  30          


Val Ile Gly Ile Asp Leu Gly Thr Thr Tyr Cys Ser Val Gly Val Phe 
        35                  40                  45              


Phe Pro Gly Thr Gly Lys Val Lys Val Ile Pro Asp Glu Asn Gly His 
    50                  55                  60                  


Ile Ser Ile Pro Ser Met Val Ser Phe Thr Asp Asn Asp Val Tyr Val 
65                  70                  75                  80  


Gly Tyr Glu Ser Val Glu Leu Ala Asp Ser Asn Pro Gln Asn Thr Ile 
                85                  90                  95      


Tyr Asp Ala Lys Arg Phe Ile Gly Lys Ile Phe Thr Ala Glu Glu Leu 
            100                 105                 110         


Glu Ala Glu Ile Gly Arg Tyr Pro Phe Lys Val Leu Asn Lys Asn Gly 
        115                 120                 125             


Met Val Glu Phe Ser Val Thr Ser Asn Glu Thr Ile Thr Val Ser Pro 
    130                 135                 140                 


Glu Tyr Val Gly Ser Arg Leu Leu Leu Lys Leu Lys Glu Met Ala Glu 
145                 150                 155                 160 


Ala Tyr Leu Gly Met Pro Val Ala Asn Ala Val Ile Ser Val Pro Ala 
                165                 170                 175     


Glu Phe Asp Leu Lys Gln Arg Asn Ser Thr Ile Glu Ala Ala Asn Leu 
            180                 185                 190         


Ala Gly Leu Lys Ile Leu Arg Val Ile Asn Glu Pro Thr Ala Ala Ala 
        195                 200                 205             


Met Ala Tyr Gly Leu His Lys Ala Asp Val Phe His Val Leu Val Ile 
    210                 215                 220                 


Asp Leu Gly Gly Gly Thr Leu Asp Val Ser Leu Leu Asn Lys Gln Gly 
225                 230                 235                 240 


Gly Met Phe Leu Thr Arg Ala Met Ser Gly Asn Asn Lys Leu Gly Gly 
                245                 250                 255     


Gln Asp Phe Asn Gln Arg Leu Leu Gln Tyr Leu Tyr Lys Gln Ile Tyr 
            260                 265                 270         


Gln Thr Tyr Gly Phe Val Pro Ser Arg Lys Glu Glu Ile His Arg Leu 
        275                 280                 285             


Arg Gln Ala Val Glu Met Val Lys Leu Asn Leu Thr Leu His Gln Ser 
    290                 295                 300                 


Ala Gln Leu Ser Val Leu Leu Thr Val Glu Glu Gln Asp Arg Lys Glu 
305                 310                 315                 320 


Pro His Ser Ser Asp Thr Glu Leu Pro Lys Asp Lys Leu Ser Ser Ala 
                325                 330                 335     


Asp Asp His Arg Val Asn Ser Gly Phe Gly Arg Gly Leu Ser Asp Lys 
            340                 345                 350         


Lys Ser Gly Glu Ser Gln Val Leu Phe Glu Thr Glu Ile Ser Arg Lys 
        355                 360                 365             


Leu Phe Asp Thr Leu Asn Glu Asp Leu Phe Gln Lys Ile Leu Val Pro 
    370                 375                 380                 


Ile Gln Gln Val Leu Lys Glu Gly His Leu Glu Lys Thr Glu Ile Asp 
385                 390                 395                 400 


Glu Val Val Leu Val Gly Gly Ser Thr Arg Ile Pro Arg Ile Arg Gln 
                405                 410                 415     


Val Ile Gln Glu Phe Phe Gly Lys Asp Pro Asn Thr Ser Val Asp Pro 
            420                 425                 430         


Asp Leu Ala Val Val Thr Gly Val Ala Ile Gln Ala Gly Ile Asp Gly 
        435                 440                 445             


Gly Ser Trp Pro Leu Gln Val Ser Ala Leu Glu Ile Pro Asn Lys His 
    450                 455                 460                 


Leu Gln Lys Thr Asn Phe Asn 
465                 470     


<210>  5210
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA14__Homo_sapiens__NP_001265134

<400>  5210

Met Ala Ala Ile Gly Val His Leu Gly Cys Thr Ser Ala Cys Val Ala 
1               5                   10                  15      


Val Tyr Lys Asp Gly Arg Ala Gly Val Val Ala Asn Asp Ala Gly Asp 
            20                  25                  30          


Arg Val Thr Pro Ala Val Val Ala Tyr Ser Glu Asn Glu Glu Ile Val 
        35                  40                  45              


Gly Leu Ala Ala Lys Gln Ser Arg Ile Arg Asn Ile Ser Asn Thr Val 
    50                  55                  60                  


Met Lys Val Lys Gln Ile Leu Gly Arg Arg Val Leu Ser Arg Asp Pro 
65                  70                  75                  80  


Gln Leu Gln Gln Leu Pro Gln Pro Phe Gln Arg Cys Ser Cys Ser Leu 
                85                  90                  95      


Ser Glu Gln Pro His Gly Gln Thr Gly Cys Val Arg Gly Ala Gln Pro 
            100                 105                 110         


Leu His Gln His Gln Pro Gln His Ser Trp Gly Ser Leu His Thr Ala 
        115                 120                 125             


Asp Ser Ser Leu Leu Phe Glu Ser Trp Phe Cys Phe Trp Trp Gly 
    130                 135                 140             


<210>  5211
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA1A__Homo_sapiens__NP_005336

<400>  5211

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  5212
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA1L__Homo_sapiens__NP_005518

<400>  5212

Met Ala Thr Ala Lys Gly Ile Ala Ile Gly Ile Asp Leu Gly Thr Thr 
1               5                   10                  15      


Tyr Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala 
            20                  25                  30          


Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp 
        35                  40                  45              


Thr Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn 
    50                  55                  60                  


Pro Gln Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe 
65                  70                  75                  80  


Asn Asp Pro Val Val Gln Ala Asp Met Lys Leu Trp Pro Phe Gln Val 
                85                  90                  95      


Ile Asn Glu Gly Gly Lys Pro Lys Val Leu Val Ser Tyr Lys Gly Glu 
            100                 105                 110         


Asn Lys Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys 
        115                 120                 125             


Leu Lys Glu Thr Ala Glu Ala Phe Leu Gly His Pro Val Thr Asn Ala 
    130                 135                 140                 


Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr 
145                 150                 155                 160 


Lys Asp Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn 
                165                 170                 175     


Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Gly Gly Gln 
            180                 185                 190         


Gly Glu Arg His Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp 
        195                 200                 205             


Val Ser Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr 
    210                 215                 220                 


Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val 
225                 230                 235                 240 


Ser His Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser 
                245                 250                 255     


Gln Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala 
            260                 265                 270         


Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Asn Leu Glu Ile Asp Ser 
        275                 280                 285             


Leu Tyr Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe 
    290                 295                 300                 


Glu Glu Leu Cys Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val Glu 
305                 310                 315                 320 


Lys Ala Leu Arg Asp Ala Lys Met Asp Lys Ala Lys Ile His Asp Ile 
                325                 330                 335     


Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Arg Leu Leu 
            340                 345                 350         


Gln Asp Tyr Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp 
        355                 360                 365             


Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly 
    370                 375                 380                 


Asp Lys Ser Glu Lys Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro 
385                 390                 395                 400 


Leu Ser Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile 
                405                 410                 415     


Lys Arg Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr 
            420                 425                 430         


Tyr Ser Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu 
        435                 440                 445             


Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Asp Leu Thr 
    450                 455                 460                 


Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe 
465                 470                 475                 480 


Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser 
                485                 490                 495     


Thr Gly Lys Val Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu 
            500                 505                 510         


Ser Lys Glu Glu Ile Glu Arg Met Val Leu Asp Ala Glu Lys Tyr Lys 
        515                 520                 525             


Ala Glu Asp Glu Val Gln Arg Glu Lys Ile Ala Ala Lys Asn Ala Leu 
    530                 535                 540                 


Glu Ser Tyr Ala Phe Asn Met Lys Ser Val Val Ser Asp Glu Gly Leu 
545                 550                 555                 560 


Lys Gly Lys Ile Ser Glu Ser Asp Lys Asn Lys Ile Leu Asp Lys Cys 
                565                 570                 575     


Asn Glu Leu Leu Ser Trp Leu Glu Val Asn Gln Leu Ala Glu Lys Asp 
            580                 585                 590         


Glu Phe Asp His Lys Arg Lys Glu Leu Glu Gln Met Cys Asn Pro Ile 
        595                 600                 605             


Ile Thr Lys Leu Tyr Gln Gly Gly Cys Thr Gly Pro Ala Cys Gly Thr 
    610                 615                 620                 


Gly Tyr Val Pro Gly Arg Pro Ala Thr Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  5213
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA2__Homo_sapiens__NP_068814

<400>  5213

Met Ser Ala Arg Gly Pro Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr 
1               5                   10                  15      


Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn 
            20                  25                  30          


Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr 
        35                  40                  45              


Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro 
    50                  55                  60                  


Thr Asn Thr Ile Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Glu 
65                  70                  75                  80  


Asp Ala Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val Val 
                85                  90                  95      


Ser Glu Gly Gly Lys Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr 
            100                 105                 110         


Lys Thr Phe Phe Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met 
        115                 120                 125             


Lys Glu Ile Ala Glu Ala Tyr Leu Gly Gly Lys Val His Ser Ala Val 
    130                 135                 140                 


Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
145                 150                 155                 160 


Asp Ala Gly Thr Ile Thr Gly Leu Asn Val Leu Arg Ile Ile Asn Glu 
                165                 170                 175     


Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Gly Cys Ala 
            180                 185                 190         


Gly Gly Glu Lys Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe 
        195                 200                 205             


Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser 
    210                 215                 220                 


Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met 
225                 230                 235                 240 


Val Ser His Leu Ala Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile 
                245                 250                 255     


Gly Pro Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg 
            260                 265                 270         


Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp 
        275                 280                 285             


Ser Leu Tyr Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg 
    290                 295                 300                 


Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val 
305                 310                 315                 320 


Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Gly Gln Ile Gln Glu 
                325                 330                 335     


Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu 
            340                 345                 350         


Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro 
        355                 360                 365             


Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ile 
    370                 375                 380                 


Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr 
385                 390                 395                 400 


Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Pro Leu 
                405                 410                 415     


Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr 
            420                 425                 430         


Thr Tyr Ser Asp Asn Gln Ser Ser Val Leu Val Gln Val Tyr Glu Gly 
        435                 440                 445             


Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Asp Leu 
    450                 455                 460                 


Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr 
465                 470                 475                 480 


Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Ala Asp Lys 
                485                 490                 495     


Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg 
            500                 505                 510         


Leu Ser Lys Asp Asp Ile Asp Arg Met Val Gln Glu Ala Glu Arg Tyr 
        515                 520                 525             


Lys Ser Glu Asp Glu Ala Asn Arg Asp Arg Val Ala Ala Lys Asn Ala 
    530                 535                 540                 


Leu Glu Ser Tyr Thr Tyr Asn Ile Lys Gln Thr Val Glu Asp Glu Lys 
545                 550                 555                 560 


Leu Arg Gly Lys Ile Ser Glu Gln Asp Lys Asn Lys Ile Leu Asp Lys 
                565                 570                 575     


Cys Gln Glu Val Ile Asn Trp Leu Asp Arg Asn Gln Met Ala Glu Lys 
            580                 585                 590         


Asp Glu Tyr Glu His Lys Gln Lys Glu Leu Glu Arg Val Cys Asn Pro 
        595                 600                 605             


Ile Ile Ser Lys Leu Tyr Gln Gly Gly Pro Gly Gly Gly Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Ala Ser Gly Gly Pro Thr Ile Glu Glu Val Asp 
625                 630                 635                 


<210>  5214
<211>  840
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA4__Homo_sapiens__NP_002145

<400>  5214

Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
        35                  40                  45              


Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
    50                  55                  60                  


Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
65                  70                  75                  80  


Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                85                  90                  95      


Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
            100                 105                 110         


Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
    130                 135                 140                 


Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
145                 150                 155                 160 


Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                165                 170                 175     


Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
            180                 185                 190         


Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
        195                 200                 205             


Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
    210                 215                 220                 


Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
225                 230                 235                 240 


Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
    290                 295                 300                 


Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
305                 310                 315                 320 


Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
385                 390                 395                 400 


Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                405                 410                 415     


Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
        435                 440                 445             


Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
    450                 455                 460                 


Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                485                 490                 495     


Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
            500                 505                 510         


Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
        515                 520                 525             


Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
    530                 535                 540                 


Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
545                 550                 555                 560 


Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                565                 570                 575     


Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
            580                 585                 590         


Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
        595                 600                 605             


Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu Tyr 
    610                 615                 620                 


Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
625                 630                 635                 640 


Ser Glu Asp Asp Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                645                 650                 655     


Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
            660                 665                 670         


Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
        675                 680                 685             


Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
    690                 695                 700                 


Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
705                 710                 715                 720 


Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                725                 730                 735     


Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
            740                 745                 750         


Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
        755                 760                 765             


Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
    770                 775                 780                 


Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
785                 790                 795                 800 


Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                805                 810                 815     


Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
            820                 825                 830         


Lys Leu Pro Glu Met Asp Ile Asp 
        835                 840 


<210>  5215
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA4L__Homo_sapiens__NP_055093

<400>  5215

Met Ser Val Val Gly Ile Asp Leu Gly Phe Leu Asn Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ser Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ala Cys Ile Ser Leu Gly Ser Arg Thr Arg Ala Ile 
        35                  40                  45              


Gly Asn Ala Ala Lys Ser Gln Ile Val Thr Asn Val Arg Asn Thr Ile 
    50                  55                  60                  


His Gly Phe Lys Lys Leu His Gly Arg Ser Phe Asp Asp Pro Ile Val 
65                  70                  75                  80  


Gln Thr Glu Arg Ile Arg Leu Pro Tyr Glu Leu Gln Lys Met Pro Asn 
                85                  90                  95      


Gly Ser Ala Gly Val Lys Val Arg Tyr Leu Glu Glu Glu Arg Pro Phe 
            100                 105                 110         


Ala Ile Glu Gln Val Thr Gly Met Leu Leu Ala Lys Leu Lys Glu Thr 
        115                 120                 125             


Ser Glu Asn Ala Leu Lys Lys Pro Val Ala Asp Cys Val Ile Ser Ile 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Met Ala Ala Ala 
145                 150                 155                 160 


Gln Val Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                165                 170                 175     


Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Pro Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Asn Val Val Phe Ile Asp Met Gly His Ser Ala Tyr 
        195                 200                 205             


Gln Val Leu Val Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Ala 
    210                 215                 220                 


Thr Thr Phe Asp Pro Tyr Leu Gly Gly Arg Asn Phe Asp Glu Ala Leu 
225                 230                 235                 240 


Val Asp Tyr Phe Cys Asp Glu Phe Lys Thr Lys Tyr Lys Ile Asn Val 
                245                 250                 255     


Lys Glu Asn Ser Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Leu Asp Val Ser Ser Lys Met Asn Arg Ala 
    290                 295                 300                 


Gln Phe Glu Gln Leu Cys Ala Ser Leu Leu Ala Arg Val Glu Pro Pro 
305                 310                 315                 320 


Leu Lys Ala Val Met Glu Gln Ala Asn Leu Gln Arg Glu Asp Ile Ser 
                325                 330                 335     


Ser Ile Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Gln Ile Thr Lys Phe Phe Leu Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Leu Val Pro Tyr 
385                 390                 395                 400 


Ser Ile Thr Leu Arg Trp Lys Thr Ser Phe Glu Asp Gly Ser Gly Glu 
                405                 410                 415     


Cys Glu Val Phe Cys Lys Asn His Pro Ala Pro Phe Ser Lys Val Ile 
            420                 425                 430         


Thr Phe His Lys Lys Glu Pro Phe Glu Leu Glu Ala Phe Tyr Thr Asn 
        435                 440                 445             


Leu His Glu Val Pro Tyr Pro Asp Ala Arg Ile Gly Ser Phe Thr Ile 
    450                 455                 460                 


Gln Asn Val Phe Pro Gln Ser Asp Gly Asp Ser Ser Lys Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Ile His Gly Ile Phe Ser Val Ala Ser Ala Ser 
                485                 490                 495     


Val Ile Glu Lys Gln Asn Leu Glu Gly Asp His Ser Asp Ala Pro Met 
            500                 505                 510         


Glu Thr Glu Thr Ser Phe Lys Asn Glu Asn Lys Asp Asn Met Asp Lys 
        515                 520                 525             


Met Gln Val Asp Gln Glu Glu Gly His Gln Lys Cys His Ala Glu His 
    530                 535                 540                 


Thr Pro Glu Glu Glu Ile Asp His Thr Gly Ala Lys Thr Lys Ser Ala 
545                 550                 555                 560 


Val Ser Asp Lys Gln Asp Arg Leu Asn Gln Thr Leu Lys Lys Gly Lys 
                565                 570                 575     


Val Lys Ser Ile Asp Leu Pro Ile Gln Ser Ser Leu Cys Arg Gln Leu 
            580                 585                 590         


Gly Gln Asp Leu Leu Asn Ser Tyr Ile Glu Asn Glu Gly Lys Met Ile 
        595                 600                 605             


Met Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val 
    610                 615                 620                 


Glu Glu Tyr Val Tyr Asp Phe Arg Asp Arg Leu Gly Thr Val Tyr Glu 
625                 630                 635                 640 


Lys Phe Ile Thr Pro Glu Asp Leu Ser Lys Leu Ser Ala Val Leu Glu 
                645                 650                 655     


Asp Thr Glu Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln 
            660                 665                 670         


Val Tyr Val Asp Lys Leu Gln Glu Leu Lys Lys Tyr Gly Gln Pro Ile 
        675                 680                 685             


Gln Met Lys Tyr Met Glu His Glu Glu Arg Pro Lys Ala Leu Asn Asp 
    690                 695                 700                 


Leu Gly Lys Lys Ile Gln Leu Val Met Lys Val Ile Glu Ala Tyr Arg 
705                 710                 715                 720 


Asn Lys Asp Glu Arg Tyr Asp His Leu Asp Pro Thr Glu Met Glu Lys 
                725                 730                 735     


Val Glu Lys Cys Ile Ser Asp Ala Met Ser Trp Leu Asn Ser Lys Met 
            740                 745                 750         


Asn Ala Gln Asn Lys Leu Ser Leu Thr Gln Asp Pro Val Val Lys Val 
        755                 760                 765             


Ser Glu Ile Val Ala Lys Ser Lys Glu Leu Asp Asn Phe Cys Asn Pro 
    770                 775                 780                 


Ile Ile Tyr Lys Pro Lys Pro Lys Ala Glu Val Pro Glu Asp Lys Pro 
785                 790                 795                 800 


Lys Ala Asn Ser Glu His Asn Gly Pro Met Asp Gly Gln Ser Gly Thr 
                805                 810                 815     


Glu Thr Lys Ser Asp Ser Thr Lys Asp Ser Ser Gln His Thr Lys Ser 
            820                 825                 830         


Ser Gly Glu Met Glu Val Asp 
        835                 


<210>  5216
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA5__Homo_sapiens__NP_005338

<400>  5216

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  5217
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA6__Homo_sapiens__NP_002146

<400>  5217

Met Gln Ala Pro Arg Glu Leu Ala Val Gly Ile Asp Leu Gly Thr Thr 
1               5                   10                  15      


Tyr Ser Cys Val Gly Val Phe Gln Gln Gly Arg Val Glu Ile Leu Ala 
            20                  25                  30          


Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp 
        35                  40                  45              


Thr Glu Arg Leu Val Gly Asp Ala Ala Lys Ser Gln Ala Ala Leu Asn 
    50                  55                  60                  


Pro His Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe 
65                  70                  75                  80  


Ala Asp Thr Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val 
                85                  90                  95      


Val Ser Glu Gly Gly Lys Pro Lys Val Arg Val Cys Tyr Arg Gly Glu 
            100                 105                 110         


Asp Lys Thr Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Ser Lys 
        115                 120                 125             


Met Lys Glu Thr Ala Glu Ala Tyr Leu Gly Gln Pro Val Lys His Ala 
    130                 135                 140                 


Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr 
145                 150                 155                 160 


Lys Asp Ala Gly Ala Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn 
                165                 170                 175     


Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Arg Gly Ala 
            180                 185                 190         


Gly Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp 
        195                 200                 205             


Val Ser Val Leu Ser Ile Asp Ala Gly Val Phe Glu Val Lys Ala Thr 
    210                 215                 220                 


Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val 
225                 230                 235                 240 


Asn His Phe Met Glu Glu Phe Arg Arg Lys His Gly Lys Asp Leu Ser 
                245                 250                 255     


Gly Asn Lys Arg Ala Leu Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala 
            260                 265                 270         


Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Thr Leu Glu Ile Asp Ser 
        275                 280                 285             


Leu Phe Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe 
    290                 295                 300                 


Glu Glu Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu 
305                 310                 315                 320 


Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Val 
                325                 330                 335     


Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu 
            340                 345                 350         


Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp 
        355                 360                 365             


Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Val Leu Met Gly 
    370                 375                 380                 


Asp Lys Cys Glu Lys Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro 
385                 390                 395                 400 


Leu Ser Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Thr Leu Ile 
                405                 410                 415     


Gln Arg Asn Ala Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr 
            420                 425                 430         


Tyr Ser Asp Asn Gln Pro Gly Val Phe Ile Gln Val Tyr Glu Gly Glu 
        435                 440                 445             


Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser 
    450                 455                 460                 


Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe 
465                 470                 475                 480 


Asp Ile Asp Ala Asn Gly Ile Leu Ser Val Thr Ala Thr Asp Arg Ser 
                485                 490                 495     


Thr Gly Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu 
            500                 505                 510         


Ser Lys Glu Glu Val Glu Arg Met Val His Glu Ala Glu Gln Tyr Lys 
        515                 520                 525             


Ala Glu Asp Glu Ala Gln Arg Asp Arg Val Ala Ala Lys Asn Ser Leu 
    530                 535                 540                 


Glu Ala His Val Phe His Val Lys Gly Ser Leu Gln Glu Glu Ser Leu 
545                 550                 555                 560 


Arg Asp Lys Ile Pro Glu Glu Asp Arg Arg Lys Met Gln Asp Lys Cys 
                565                 570                 575     


Arg Glu Val Leu Ala Trp Leu Glu His Asn Gln Leu Ala Glu Lys Glu 
            580                 585                 590         


Glu Tyr Glu His Gln Lys Arg Glu Leu Glu Gln Ile Cys Arg Pro Ile 
        595                 600                 605             


Phe Ser Arg Leu Tyr Gly Gly Pro Gly Val Pro Gly Gly Ser Ser Cys 
    610                 615                 620                 


Gly Thr Gln Ala Arg Gln Gly Asp Pro Ser Thr Gly Pro Ile Ile Glu 
625                 630                 635                 640 


Glu Val Asp 
            


<210>  5218
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA8__Homo_sapiens__NP_006588

<400>  5218

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  5219
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPA9__Homo_sapiens__NP_004125

<400>  5219

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  5220
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPB1__Homo_sapiens__NP_001531

<400>  5220

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  5221
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPB2__Homo_sapiens__NP_001532

<400>  5221

Met Ser Gly Arg Ser Val Pro His Ala His Pro Ala Thr Ala Glu Tyr 
1               5                   10                  15      


Glu Phe Ala Asn Pro Ser Arg Leu Gly Glu Gln Arg Phe Gly Glu Gly 
            20                  25                  30          


Leu Leu Pro Glu Glu Ile Leu Thr Pro Thr Leu Tyr His Gly Tyr Tyr 
        35                  40                  45              


Val Arg Pro Arg Ala Ala Pro Ala Gly Glu Gly Ser Arg Ala Gly Ala 
    50                  55                  60                  


Ser Glu Leu Arg Leu Ser Glu Gly Lys Phe Gln Ala Phe Leu Asp Val 
65                  70                  75                  80  


Ser His Phe Thr Pro Asp Glu Val Thr Val Arg Thr Val Asp Asn Leu 
                85                  90                  95      


Leu Glu Val Ser Ala Arg His Pro Gln Arg Leu Asp Arg His Gly Phe 
            100                 105                 110         


Val Ser Arg Glu Phe Cys Arg Thr Tyr Val Leu Pro Ala Asp Val Asp 
        115                 120                 125             


Pro Trp Arg Val Arg Ala Ala Leu Ser His Asp Gly Ile Leu Asn Leu 
    130                 135                 140                 


Glu Ala Pro Arg Gly Gly Arg His Leu Asp Thr Glu Val Asn Glu Val 
145                 150                 155                 160 


Tyr Ile Ser Leu Leu Pro Ala Pro Pro Asp Pro Glu Glu Glu Glu Glu 
                165                 170                 175     


Ala Ala Ile Val Glu Pro 
            180         


<210>  5222
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPB3__Homo_sapiens__NP_006299

<400>  5222

Met Ala Lys Ile Ile Leu Arg His Leu Ile Glu Ile Pro Val Arg Tyr 
1               5                   10                  15      


Gln Glu Glu Phe Glu Ala Arg Gly Leu Glu Asp Cys Arg Leu Asp His 
            20                  25                  30          


Ala Leu Tyr Ala Leu Pro Gly Pro Thr Ile Val Asp Leu Arg Lys Thr 
        35                  40                  45              


Arg Ala Ala Gln Ser Pro Pro Val Asp Ser Ala Ala Glu Thr Pro Pro 
    50                  55                  60                  


Arg Glu Gly Lys Ser His Phe Gln Ile Leu Leu Asp Val Val Gln Phe 
65                  70                  75                  80  


Leu Pro Glu Asp Ile Ile Ile Gln Thr Phe Glu Gly Trp Leu Leu Ile 
                85                  90                  95      


Lys Ala Gln His Gly Thr Arg Met Asp Glu His Gly Phe Ile Ser Arg 
            100                 105                 110         


Ser Phe Thr Arg Gln Tyr Lys Leu Pro Asp Gly Val Glu Ile Lys Asp 
        115                 120                 125             


Leu Ser Ala Val Leu Cys His Asp Gly Ile Leu Val Val Glu Val Lys 
    130                 135                 140                 


Asp Pro Val Gly Thr Lys 
145                 150 


<210>  5223
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPB6__Homo_sapiens__NP_653218

<400>  5223

Met Glu Ile Pro Val Pro Val Gln Pro Ser Trp Leu Arg Arg Ala Ser 
1               5                   10                  15      


Ala Pro Leu Pro Gly Leu Ser Ala Pro Gly Arg Leu Phe Asp Gln Arg 
            20                  25                  30          


Phe Gly Glu Gly Leu Leu Glu Ala Glu Leu Ala Ala Leu Cys Pro Thr 
        35                  40                  45              


Thr Leu Ala Pro Tyr Tyr Leu Arg Ala Pro Ser Val Ala Leu Pro Val 
    50                  55                  60                  


Ala Gln Val Pro Thr Asp Pro Gly His Phe Ser Val Leu Leu Asp Val 
65                  70                  75                  80  


Lys His Phe Ser Pro Glu Glu Ile Ala Val Lys Val Val Gly Glu His 
                85                  90                  95      


Val Glu Val His Ala Arg His Glu Glu Arg Pro Asp Glu His Gly Phe 
            100                 105                 110         


Val Ala Arg Glu Phe His Arg Arg Tyr Arg Leu Pro Pro Gly Val Asp 
        115                 120                 125             


Pro Ala Ala Val Thr Ser Ala Leu Ser Pro Glu Gly Val Leu Ser Ile 
    130                 135                 140                 


Gln Ala Ala Pro Ala Ser Ala Gln Ala Pro Pro Pro Ala Ala Ala Lys 
145                 150                 155                 160 


<210>  5224
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPB7__Homo_sapiens__XP_011539551

<400>  5224

Met Ser Gly Cys Glu Leu Ser Pro Leu Gly Leu Arg Val Gly Leu Ser 
1               5                   10                  15      


Ala Gly Pro Ala His Gly Arg Arg Phe Pro Ala Pro Ser Gly Pro Trp 
            20                  25                  30          


Arg Gly Leu Asn Leu Ala Ser Arg Gln Gly Ala Gly Pro Lys Pro Arg 
        35                  40                  45              


Asp Ser Arg Pro Tyr Lys Ala Ala Ala Val Gly Ala Trp His Ala Arg 
    50                  55                  60                  


Pro Glu Ala Cys Ala His Thr Leu Ser Cys Pro Ala Leu Ala Arg Leu 
65                  70                  75                  80  


Gly Arg Ala Arg Arg Arg Pro Trp Met Ser His Arg Thr Ser Ser Thr 
                85                  90                  95      


Phe Arg Ala Glu Arg Ser Phe His Ser Ser Ser Ser Ser Ser Ser Ser 
            100                 105                 110         


Ser Thr Ser Ser Ser Ala Ser Arg Ala Leu Pro Ala Gln Asp Pro Pro 
        115                 120                 125             


Met Glu Lys Ala Leu Ser Met Phe Ser Asp Asp Phe Gly Ser Phe Met 
    130                 135                 140                 


Arg Pro His Ser Glu Pro Leu Ala Phe Pro Ala Ala His Pro Thr Ala 
145                 150                 155                 160 


Arg Pro Gly Gly Ala Gly Asn Ile Lys Thr Leu Gly Asp Ala Tyr Glu 
                165                 170                 175     


Phe Ala Val Asp Val Arg Asp Phe Ser Pro Glu Asp Ile Ile Val Thr 
            180                 185                 190         


Thr Ser Asn Asn His Ile Glu Val Arg Ala Glu Lys Leu Ala Ala Asp 
        195                 200                 205             


Gly Thr Val Met Asn Thr Phe Ala His Lys Cys Gln Leu Pro Glu Asp 
    210                 215                 220                 


Val Asp Pro Thr Ser Val Thr Ser Ala Leu Arg Glu Asp Gly Ser Leu 
225                 230                 235                 240 


Thr Ile Arg Ala Arg Arg His Pro His Thr Glu His Val Gln Gln Thr 
                245                 250                 255     


Phe Arg Thr Glu Ile Lys Ile 
            260             


<210>  5225
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPB8__Homo_sapiens__NP_055180

<400>  5225

Met Ala Asp Gly Gln Met Pro Phe Ser Cys His Tyr Pro Ser Arg Leu 
1               5                   10                  15      


Arg Arg Asp Pro Phe Arg Asp Ser Pro Leu Ser Ser Arg Leu Leu Asp 
            20                  25                  30          


Asp Gly Phe Gly Met Asp Pro Phe Pro Asp Asp Leu Thr Ala Ser Trp 
        35                  40                  45              


Pro Asp Trp Ala Leu Pro Arg Leu Ser Ser Ala Trp Pro Gly Thr Leu 
    50                  55                  60                  


Arg Ser Gly Met Val Pro Arg Gly Pro Thr Ala Thr Ala Arg Phe Gly 
65                  70                  75                  80  


Val Pro Ala Glu Gly Arg Thr Pro Pro Pro Phe Pro Gly Glu Pro Trp 
                85                  90                  95      


Lys Val Cys Val Asn Val His Ser Phe Lys Pro Glu Glu Leu Met Val 
            100                 105                 110         


Lys Thr Lys Asp Gly Tyr Val Glu Val Ser Gly Lys His Glu Glu Lys 
        115                 120                 125             


Gln Gln Glu Gly Gly Ile Val Ser Lys Asn Phe Thr Lys Lys Ile Gln 
    130                 135                 140                 


Leu Pro Ala Glu Val Asp Pro Val Thr Val Phe Ala Ser Leu Ser Pro 
145                 150                 155                 160 


Glu Gly Leu Leu Ile Ile Glu Ala Pro Gln Val Pro Pro Tyr Ser Thr 
                165                 170                 175     


Phe Gly Glu Ser Ser Phe Asn Asn Glu Leu Pro Gln Asp Ser Gln Glu 
            180                 185                 190         


Val Thr Cys Thr 
        195     


<210>  5226
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPB9__Homo_sapiens__NP_149971

<400>  5226

Met Gln Arg Val Gly Asn Thr Phe Ser Asn Glu Ser Arg Val Ala Ser 
1               5                   10                  15      


Arg Cys Pro Ser Val Gly Leu Ala Glu Arg Asn Arg Val Ala Thr Met 
            20                  25                  30          


Pro Val Arg Leu Leu Arg Asp Ser Pro Ala Ala Gln Glu Asp Asn Asp 
        35                  40                  45              


His Ala Arg Asp Gly Phe Gln Met Lys Leu Asp Ala His Gly Phe Ala 
    50                  55                  60                  


Pro Glu Glu Leu Val Val Gln Val Asp Gly Gln Trp Leu Met Val Thr 
65                  70                  75                  80  


Gly Gln Gln Gln Leu Asp Val Arg Asp Pro Glu Arg Val Ser Tyr Arg 
                85                  90                  95      


Met Ser Gln Lys Val His Arg Lys Met Leu Pro Ser Asn Leu Ser Pro 
            100                 105                 110         


Thr Ala Met Thr Cys Cys Leu Thr Pro Ser Gly Gln Leu Trp Val Arg 
        115                 120                 125             


Gly Gln Cys Val Ala Leu Ala Leu Pro Glu Ala Gln Thr Gly Pro Ser 
    130                 135                 140                 


Pro Arg Leu Gly Ser Leu Gly Ser Lys Ala Ser Asn Leu Thr Arg 
145                 150                 155                 


<210>  5227
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPBAP1__Homo_sapiens__NP_078886

<400>  5227

Met Ala Ala Gly Ser Glu Ala Thr Thr Pro Val Ile Val Ala Ala Gly 
1               5                   10                  15      


Ala Gly Gly Glu Glu Gly Glu His Val Lys Pro Phe Lys Pro Glu Lys 
            20                  25                  30          


Ala Lys Glu Ile Ile Met Ser Leu Gln Gln Pro Ala Ile Phe Cys Asn 
        35                  40                  45              


Met Val Phe Asp Trp Pro Ala Arg His Trp Asn Ala Lys Tyr Leu Ser 
    50                  55                  60                  


Gln Val Leu His Gly Lys Gln Ile Arg Phe Arg Met Gly Met Lys Ser 
65                  70                  75                  80  


Met Ser Thr Val Pro Gln Phe Glu Thr Thr Cys Asn Tyr Val Glu Ala 
                85                  90                  95      


Thr Leu Glu Glu Phe Leu Thr Trp Asn Cys Asp Gln Ser Ser Ile Ser 
            100                 105                 110         


Gly Pro Phe Arg Asp Tyr Asp His Ser Lys Phe Trp Ala Tyr Ala Asp 
        115                 120                 125             


Tyr Lys Tyr Phe Val Ser Leu Phe Glu Asp Lys Thr Asp Leu Phe Gln 
    130                 135                 140                 


Asp Val Lys Trp Ser Asp Phe Gly Phe Pro Gly Arg Asn Gly Gln Glu 
145                 150                 155                 160 


Ser Thr Leu Trp Ile Gly Ser Leu Gly Ala His Thr Pro Cys His Leu 
                165                 170                 175     


Asp Ser Tyr Gly Cys Asn Leu Val Phe Gln Val Gln Gly Arg Lys Arg 
            180                 185                 190         


Trp His Leu Phe Pro Pro Glu Asp Thr Pro Phe Leu Tyr Pro Thr Arg 
        195                 200                 205             


Ile Pro Tyr Glu Glu Ser Ser Val Phe Ser Lys Ile Asn Val Val Asn 
    210                 215                 220                 


Pro Asp Leu Lys Arg Phe Pro Gln Phe Arg Lys Ala Gln Arg His Ala 
225                 230                 235                 240 


Val Thr Leu Ser Pro Gly Gln Val Leu Phe Val Pro Arg His Trp Trp 
                245                 250                 255     


His Tyr Val Glu Ser Ile Asp Pro Val Thr Val Ser Ile Asn Ser Trp 
            260                 265                 270         


Ile Glu Leu Glu Glu Asp His Leu Ala Arg Val Glu Glu Ala Ile Thr 
        275                 280                 285             


Arg Met Leu Val Cys Ala Leu Lys Thr Ala Glu Asn Pro Gln Asn Thr 
    290                 295                 300                 


Arg Ala Trp Leu Asn Pro Thr Glu Val Glu Glu Thr Ser His Ala Val 
305                 310                 315                 320 


Asn Cys Cys Tyr Leu Asn Ala Ala Val Ser Ala Phe Phe Asp Arg Cys 
                325                 330                 335     


Arg Thr Ser Glu Val Val Glu Ile Gln Ala Leu Arg Thr Asp Gly Glu 
            340                 345                 350         


His Met Lys Lys Glu Glu Leu Asn Val Cys Asn His Met Glu Val Gly 
        355                 360                 365             


Gln Thr Gly Ser Gln Asn Leu Thr Thr Gly Thr Asp Lys Pro Glu Ala 
    370                 375                 380                 


Ala Ser Pro Phe Gly Pro Asp Leu Val Pro Val Ala Gln Arg Ser Glu 
385                 390                 395                 400 


Glu Pro Pro Ser Glu Arg Gly Gly Ile Phe Gly Ser Asp Gly Lys Asp 
                405                 410                 415     


Phe Val Asp Lys Asp Gly Glu His Phe Gly Lys Leu His Cys Ala Lys 
            420                 425                 430         


Arg Gln Gln Ile Met Ser Asn Ser Glu Asn Ala Ile Glu Glu Gln Ile 
        435                 440                 445             


Ala Ser Asn Thr Thr Thr Thr Pro Gln Thr Phe Ile Ser Thr Asp Asp 
    450                 455                 460                 


Leu Leu Asp Cys Leu Val Asn Pro Gln Val Thr Arg Ile Val Ala Gln 
465                 470                 475                 480 


Leu Leu Ile Gln Gly Arg Ser Leu 
                485             


<210>  5228
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPBP1__Homo_sapiens__NP_001123578

<400>  5228

Met Ser Asp Glu Gly Ser Arg Gly Ser Arg Leu Pro Leu Ala Leu Pro 
1               5                   10                  15      


Pro Ala Ser Gln Gly Cys Ser Ser Gly Gly Gly Gly Gly Gly Ser Ser 
            20                  25                  30          


Ala Gly Gly Ser Gly Asn Ser Arg Pro Pro Arg Asn Leu Gln Gly Leu 
        35                  40                  45              


Leu Gln Met Ala Ile Thr Ala Gly Ser Glu Glu Pro Asp Pro Pro Pro 
    50                  55                  60                  


Glu Pro Met Ser Glu Glu Arg Arg Gln Trp Leu Gln Glu Ala Met Ser 
65                  70                  75                  80  


Ala Ala Phe Arg Gly Gln Arg Glu Glu Val Glu Gln Met Lys Ser Cys 
                85                  90                  95      


Leu Arg Val Leu Ser Gln Pro Met Pro Pro Thr Ala Gly Glu Ala Glu 
            100                 105                 110         


Gln Ala Ala Asp Gln Gln Glu Arg Glu Gly Ala Leu Glu Leu Leu Ala 
        115                 120                 125             


Asp Leu Cys Glu Asn Met Asp Asn Ala Ala Asp Phe Cys Gln Leu Ser 
    130                 135                 140                 


Gly Met His Leu Leu Val Gly Arg Tyr Leu Glu Ala Gly Ala Ala Gly 
145                 150                 155                 160 


Leu Arg Trp Arg Ala Ala Gln Leu Ile Gly Thr Cys Ser Gln Asn Val 
                165                 170                 175     


Ala Ala Ile Gln Glu Gln Val Leu Gly Leu Gly Ala Leu Arg Lys Leu 
            180                 185                 190         


Leu Arg Leu Leu Asp Arg Asp Ala Cys Asp Thr Val Arg Val Lys Ala 
        195                 200                 205             


Leu Phe Ala Ile Ser Cys Leu Val Arg Glu Gln Glu Ala Gly Leu Leu 
    210                 215                 220                 


Gln Phe Leu Arg Leu Asp Gly Phe Ser Val Leu Met Arg Ala Met Gln 
225                 230                 235                 240 


Gln Gln Val Gln Lys Leu Lys Val Lys Ser Ala Phe Leu Leu Gln Asn 
                245                 250                 255     


Leu Leu Val Gly His Pro Glu His Lys Gly Thr Leu Cys Ser Met Gly 
            260                 265                 270         


Met Val Gln Gln Leu Val Ala Leu Val Arg Thr Glu His Ser Pro Phe 
        275                 280                 285             


His Glu His Val Leu Gly Ala Leu Cys Ser Leu Val Thr Asp Phe Pro 
    290                 295                 300                 


Gln Gly Val Arg Glu Cys Arg Glu Pro Glu Leu Gly Leu Glu Glu Leu 
305                 310                 315                 320 


Leu Arg His Arg Cys Gln Leu Leu Gln Gln His Glu Glu Tyr Gln Glu 
                325                 330                 335     


Glu Leu Glu Phe Cys Glu Lys Leu Leu Gln Thr Cys Phe Ser Ser Pro 
            340                 345                 350         


Ala Asp Asp Ser Met Asp Arg 
        355                 


<210>  5229
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPD1__Homo_sapiens__NP_002147

<400>  5229

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  5230
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPE1__Homo_sapiens__NP_002148

<400>  5230

Met Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val 
1               5                   10                  15      


Leu Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met 
            20                  25                  30          


Leu Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala 
        35                  40                  45              


Val Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser 
    50                  55                  60                  


Val Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys 
65                  70                  75                  80  


Val Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile 
                85                  90                  95      


Leu Gly Lys Tyr Val Asp 
            100         


<210>  5231
<211>  4392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPG2__Homo_sapiens__NP_001278789

<400>  5231

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Ala Gly Pro Cys Pro Asp Gly His Phe Tyr 
            500                 505                 510         


Leu Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr 
        515                 520                 525             


Ser Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg 
    530                 535                 540                 


Phe Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala 
545                 550                 555                 560 


Gln Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro 
                565                 570                 575     


Ser Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val 
            580                 585                 590         


His Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val 
        595                 600                 605             


Asp Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala 
    610                 615                 620                 


Arg Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly 
625                 630                 635                 640 


Ala Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly 
                645                 650                 655     


Ala Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His 
            660                 665                 670         


Glu Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln 
        675                 680                 685             


Ser Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala 
    690                 695                 700                 


Ser Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala 
705                 710                 715                 720 


Thr Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile 
                725                 730                 735     


Gly Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg 
            740                 745                 750         


Val Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn 
        755                 760                 765             


Gly His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys 
    770                 775                 780                 


Gln His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe 
785                 790                 795                 800 


Phe Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro 
                805                 810                 815     


Cys Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu 
            820                 825                 830         


Asp Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr 
        835                 840                 845             


Gly Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile 
    850                 855                 860                 


Gln Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys 
865                 870                 875                 880 


Asp Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys 
                885                 890                 895     


Asn Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe 
            900                 905                 910         


His Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met 
        915                 920                 925             


Gly Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu 
    930                 935                 940                 


His Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala 
945                 950                 955                 960 


Ser Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu 
                965                 970                 975     


Leu Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp 
            980                 985                 990         


Ser Leu Pro Ser Arg Phe Leu Gly  Asp Lys Val Thr Ser  Tyr Gly Gly 
        995                 1000                 1005             


Glu Leu  Arg Phe Thr Val Thr  Gln Arg Ser Gln Pro  Gly Ser Thr 
    1010                 1015                 1020             


Pro Leu  His Gly Gln Pro Leu  Val Val Leu Gln Gly  Asn Asn Ile 
    1025                 1030                 1035             


Ile Leu  Glu His His Val Ala  Gln Glu Pro Ser Pro  Gly Gln Pro 
    1040                 1045                 1050             


Ser Thr  Phe Ile Val Pro Phe  Arg Glu Gln Ala Trp  Gln Arg Pro 
    1055                 1060                 1065             


Asp Gly  Gln Pro Ala Thr Arg  Glu His Leu Leu Met  Ala Leu Ala 
    1070                 1075                 1080             


Gly Ile  Asp Thr Leu Leu Ile  Arg Ala Ser Tyr Ala  Gln Gln Pro 
    1085                 1090                 1095             


Ala Glu  Ser Arg Val Ser Gly  Ile Ser Met Asp Val  Ala Val Pro 
    1100                 1105                 1110             


Glu Glu  Thr Gly Gln Asp Pro  Ala Leu Glu Val Glu  Gln Cys Ser 
    1115                 1120                 1125             


Cys Pro  Pro Gly Tyr Arg Gly  Pro Ser Cys Gln Asp  Cys Asp Thr 
    1130                 1135                 1140             


Gly Tyr  Thr Arg Thr Pro Ser  Gly Leu Tyr Leu Gly  Thr Cys Glu 
    1145                 1150                 1155             


Arg Cys  Ser Cys His Gly His  Ser Glu Ala Cys Glu  Pro Glu Thr 
    1160                 1165                 1170             


Gly Ala  Cys Gln Gly Cys Gln  His His Thr Glu Gly  Pro Arg Cys 
    1175                 1180                 1185             


Glu Gln  Cys Gln Pro Gly Tyr  Tyr Gly Asp Ala Gln  Arg Gly Thr 
    1190                 1195                 1200             


Pro Gln  Asp Cys Gln Leu Cys  Pro Cys Tyr Gly Asp  Pro Ala Ala 
    1205                 1210                 1215             


Gly Gln  Ala Ala His Thr Cys  Phe Leu Asp Thr Asp  Gly His Pro 
    1220                 1225                 1230             


Thr Cys  Asp Ala Cys Ser Pro  Gly His Ser Gly Arg  His Cys Glu 
    1235                 1240                 1245             


Arg Cys  Ala Pro Gly Tyr Tyr  Gly Asn Pro Ser Gln  Gly Gln Pro 
    1250                 1255                 1260             


Cys Gln  Arg Asp Ser Gln Val  Pro Gly Pro Ile Gly  Cys Asn Cys 
    1265                 1270                 1275             


Asp Pro  Gln Gly Ser Val Ser  Ser Gln Cys Asp Ala  Ala Gly Gln 
    1280                 1285                 1290             


Cys Gln  Cys Lys Ala Gln Val  Glu Gly Leu Thr Cys  Ser His Cys 
    1295                 1300                 1305             


Arg Pro  His His Phe His Leu  Ser Ala Ser Asn Pro  Asp Gly Cys 
    1310                 1315                 1320             


Leu Pro  Cys Phe Cys Met Gly  Ile Thr Gln Gln Cys  Ala Ser Ser 
    1325                 1330                 1335             


Ala Tyr  Thr Arg His Leu Ile  Ser Thr His Phe Ala  Pro Gly Asp 
    1340                 1345                 1350             


Phe Gln  Gly Phe Ala Leu Val  Asn Pro Gln Arg Asn  Ser Arg Leu 
    1355                 1360                 1365             


Thr Gly  Glu Phe Thr Val Glu  Pro Val Pro Glu Gly  Ala Gln Leu 
    1370                 1375                 1380             


Ser Phe  Gly Asn Phe Ala Gln  Leu Gly His Glu Ser  Phe Tyr Trp 
    1385                 1390                 1395             


Gln Leu  Pro Glu Thr Tyr Gln  Gly Asp Lys Val Ala  Ala Tyr Gly 
    1400                 1405                 1410             


Gly Lys  Leu Arg Tyr Thr Leu  Ser Tyr Thr Ala Gly  Pro Gln Gly 
    1415                 1420                 1425             


Ser Pro  Leu Ser Asp Pro Asp  Val Gln Ile Thr Gly  Asn Asn Ile 
    1430                 1435                 1440             


Met Leu  Val Ala Ser Gln Pro  Ala Leu Gln Gly Pro  Glu Arg Arg 
    1445                 1450                 1455             


Ser Tyr  Glu Ile Met Phe Arg  Glu Glu Phe Trp Arg  Arg Pro Asp 
    1460                 1465                 1470             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Asp 
    1475                 1480                 1485             


Leu Asp  Glu Leu Leu Ile Arg  Ala Thr Phe Ser Ser  Val Pro Leu 
    1490                 1495                 1500             


Ala Ala  Ser Ile Ser Ala Val  Ser Leu Glu Val Ala  Gln Pro Gly 
    1505                 1510                 1515             


Pro Ser  Asn Arg Pro Arg Ala  Leu Glu Val Glu Glu  Cys Arg Cys 
    1520                 1525                 1530             


Pro Pro  Gly Tyr Ile Gly Leu  Ser Cys Gln Asp Cys  Ala Pro Gly 
    1535                 1540                 1545             


Tyr Thr  Arg Thr Gly Ser Gly  Leu Tyr Leu Gly His  Cys Glu Leu 
    1550                 1555                 1560             


Cys Glu  Cys Asn Gly His Ser  Asp Leu Cys His Pro  Glu Thr Gly 
    1565                 1570                 1575             


Ala Cys  Ser Gln Cys Gln His  Asn Ala Ala Gly Glu  Phe Cys Glu 
    1580                 1585                 1590             


Leu Cys  Ala Pro Gly Tyr Tyr  Gly Asp Ala Thr Ala  Gly Thr Pro 
    1595                 1600                 1605             


Glu Asp  Cys Gln Pro Cys Ala  Cys Pro Leu Thr Asn  Pro Glu Asn 
    1610                 1615                 1620             


Met Phe  Ser Arg Thr Cys Glu  Ser Leu Gly Ala Gly  Gly Tyr Arg 
    1625                 1630                 1635             


Cys Thr  Ala Cys Glu Pro Gly  Tyr Thr Gly Gln Tyr  Cys Glu Gln 
    1640                 1645                 1650             


Cys Gly  Pro Gly Tyr Val Gly  Asn Pro Ser Val Gln  Gly Gly Gln 
    1655                 1660                 1665             


Cys Leu  Pro Glu Thr Asn Gln  Ala Pro Leu Val Val  Glu Val His 
    1670                 1675                 1680             


Pro Ala  Arg Ser Ile Val Pro  Gln Gly Gly Ser His  Ser Leu Arg 
    1685                 1690                 1695             


Cys Gln  Val Ser Gly Ser Pro  Pro His Tyr Phe Tyr  Trp Ser Arg 
    1700                 1705                 1710             


Glu Asp  Gly Arg Pro Val Pro  Ser Gly Thr Gln Gln  Arg His Gln 
    1715                 1720                 1725             


Gly Ser  Glu Leu His Phe Pro  Ser Val Gln Pro Ser  Asp Ala Gly 
    1730                 1735                 1740             


Val Tyr  Ile Cys Thr Cys Arg  Asn Leu His Gln Ser  Asn Thr Ser 
    1745                 1750                 1755             


Arg Ala  Glu Leu Leu Val Thr  Glu Ala Pro Ser Lys  Pro Ile Thr 
    1760                 1765                 1770             


Val Thr  Val Glu Glu Gln Arg  Ser Gln Ser Val Arg  Pro Gly Ala 
    1775                 1780                 1785             


Asp Val  Thr Phe Ile Cys Thr  Ala Lys Ser Lys Ser  Pro Ala Tyr 
    1790                 1795                 1800             


Thr Leu  Val Trp Thr Arg Leu  His Asn Gly Lys Leu  Pro Thr Arg 
    1805                 1810                 1815             


Ala Met  Asp Phe Asn Gly Ile  Leu Thr Ile Arg Asn  Val Gln Leu 
    1820                 1825                 1830             


Ser Asp  Ala Gly Thr Tyr Val  Cys Thr Gly Ser Asn  Met Phe Ala 
    1835                 1840                 1845             


Met Asp  Gln Gly Thr Ala Thr  Leu His Val Gln Ala  Ser Gly Thr 
    1850                 1855                 1860             


Leu Ser  Ala Pro Val Val Ser  Ile His Pro Pro Gln  Leu Thr Val 
    1865                 1870                 1875             


Gln Pro  Gly Gln Leu Ala Glu  Phe Arg Cys Ser Ala  Thr Gly Ser 
    1880                 1885                 1890             


Pro Thr  Pro Thr Leu Glu Trp  Thr Gly Gly Pro Gly  Gly Gln Leu 
    1895                 1900                 1905             


Pro Ala  Lys Ala Gln Ile His  Gly Gly Ile Leu Arg  Leu Pro Ala 
    1910                 1915                 1920             


Val Glu  Pro Thr Asp Gln Ala  Gln Tyr Leu Cys Arg  Ala His Ser 
    1925                 1930                 1935             


Ser Ala  Gly Gln Gln Val Ala  Arg Ala Val Leu His  Val His Gly 
    1940                 1945                 1950             


Gly Gly  Gly Pro Arg Val Gln  Val Ser Pro Glu Arg  Thr Gln Val 
    1955                 1960                 1965             


His Ala  Gly Arg Thr Val Arg  Leu Tyr Cys Arg Ala  Ala Gly Val 
    1970                 1975                 1980             


Pro Ser  Ala Thr Ile Thr Trp  Arg Lys Glu Gly Gly  Ser Leu Pro 
    1985                 1990                 1995             


Pro Gln  Ala Arg Ser Glu Arg  Thr Asp Ile Ala Thr  Leu Leu Ile 
    2000                 2005                 2010             


Pro Ala  Ile Thr Thr Ala Asp  Ala Gly Phe Tyr Leu  Cys Val Ala 
    2015                 2020                 2025             


Thr Ser  Pro Ala Gly Thr Ala  Gln Ala Arg Ile Gln  Val Val Val 
    2030                 2035                 2040             


Leu Ser  Ala Ser Asp Ala Ser  Pro Pro Pro Val Lys  Ile Glu Ser 
    2045                 2050                 2055             


Ser Ser  Pro Ser Val Thr Glu  Gly Gln Thr Leu Asp  Leu Asn Cys 
    2060                 2065                 2070             


Val Val  Ala Gly Ser Ala His  Ala Gln Val Thr Trp  Tyr Arg Arg 
    2075                 2080                 2085             


Gly Gly  Ser Leu Pro Pro His  Thr Gln Val His Gly  Ser Arg Leu 
    2090                 2095                 2100             


Arg Leu  Pro Gln Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2105                 2110                 2115             


Arg Val  Glu Asn Gly Ser Gly  Pro Lys Glu Ala Ser  Ile Thr Val 
    2120                 2125                 2130             


Ser Val  Leu His Gly Thr His  Ser Gly Pro Ser Tyr  Thr Pro Val 
    2135                 2140                 2145             


Pro Gly  Ser Thr Arg Pro Ile  Arg Ile Glu Pro Ser  Ser Ser His 
    2150                 2155                 2160             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Asn Cys Val  Val Pro Gly 
    2165                 2170                 2175             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Ser Leu 
    2180                 2185                 2190             


Pro Ala  Arg His Gln Thr His  Gly Ser Leu Leu Arg  Leu His Gln 
    2195                 2200                 2205             


Val Thr  Pro Ala Asp Ser Gly  Glu Tyr Val Cys His  Val Val Gly 
    2210                 2215                 2220             


Thr Ser  Gly Pro Leu Glu Ala  Ser Val Leu Val Thr  Ile Glu Ala 
    2225                 2230                 2235             


Ser Val  Ile Pro Gly Pro Ile  Pro Pro Val Arg Ile  Glu Ser Ser 
    2240                 2245                 2250             


Ser Ser  Thr Val Ala Glu Gly  Gln Thr Leu Asp Leu  Ser Cys Val 
    2255                 2260                 2265             


Val Ala  Gly Gln Ala His Ala  Gln Val Thr Trp Tyr  Lys Arg Gly 
    2270                 2275                 2280             


Gly Ser  Leu Pro Ala Arg His  Gln Val Arg Gly Ser  Arg Leu Tyr 
    2285                 2290                 2295             


Ile Phe  Gln Ala Ser Pro Ala  Asp Ala Gly Gln Tyr  Val Cys Arg 
    2300                 2305                 2310             


Ala Ser  Asn Gly Met Glu Ala  Ser Ile Thr Val Thr  Val Thr Gly 
    2315                 2320                 2325             


Thr Gln  Gly Ala Asn Leu Ala  Tyr Pro Ala Gly Ser  Thr Gln Pro 
    2330                 2335                 2340             


Ile Arg  Ile Glu Pro Ser Ser  Ser Gln Val Ala Glu  Gly Gln Thr 
    2345                 2350                 2355             


Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln Ser His  Ala Gln Val 
    2360                 2365                 2370             


Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro Val Arg  His Gln Thr 
    2375                 2380                 2385             


His Gly  Ser Leu Leu Arg Leu  Tyr Gln Ala Ser Pro  Ala Asp Ser 
    2390                 2395                 2400             


Gly Glu  Tyr Val Cys Arg Val  Leu Gly Ser Ser Val  Pro Leu Glu 
    2405                 2410                 2415             


Ala Ser  Val Leu Val Thr Ile  Glu Pro Ala Gly Ser  Val Pro Ala 
    2420                 2425                 2430             


Leu Gly  Val Thr Pro Thr Val  Arg Ile Glu Ser Ser  Ser Ser Gln 
    2435                 2440                 2445             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Asn Cys Leu  Val Ala Gly 
    2450                 2455                 2460             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Ser Leu 
    2465                 2470                 2475             


Pro Ala  Arg His Gln Val His  Gly Ser Arg Leu Arg  Leu Leu Gln 
    2480                 2485                 2490             


Val Thr  Pro Ala Asp Ser Gly  Glu Tyr Val Cys Arg  Val Val Gly 
    2495                 2500                 2505             


Ser Ser  Gly Thr Gln Glu Ala  Ser Val Leu Val Thr  Ile Gln Gln 
    2510                 2515                 2520             


Arg Leu  Ser Gly Ser His Ser  Gln Gly Val Ala Tyr  Pro Val Arg 
    2525                 2530                 2535             


Ile Glu  Ser Ser Ser Ala Ser  Leu Ala Asn Gly His  Thr Leu Asp 
    2540                 2545                 2550             


Leu Asn  Cys Leu Val Ala Ser  Gln Ala Pro His Thr  Ile Thr Trp 
    2555                 2560                 2565             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg His Gln  Ile Val Gly 
    2570                 2575                 2580             


Ser Arg  Leu Arg Ile Pro Gln  Val Thr Pro Ala Asp  Ser Gly Glu 
    2585                 2590                 2595             


Tyr Val  Cys His Val Ser Asn  Gly Ala Gly Ser Arg  Glu Thr Ser 
    2600                 2605                 2610             


Leu Ile  Val Thr Ile Gln Gly  Ser Gly Ser Ser His  Val Pro Ser 
    2615                 2620                 2625             


Val Ser  Pro Pro Ile Arg Ile  Glu Ser Ser Ser Pro  Thr Val Val 
    2630                 2635                 2640             


Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val Val Ala  Arg Gln Pro 
    2645                 2650                 2655             


Gln Ala  Ile Ile Thr Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ser 
    2660                 2665                 2670             


Arg His  Gln Thr His Gly Ser  His Leu Arg Leu His  Gln Met Ser 
    2675                 2680                 2685             


Val Ala  Asp Ser Gly Glu Tyr  Val Cys Arg Ala Asn  Asn Asn Ile 
    2690                 2695                 2700             


Asp Ala  Leu Glu Ala Ser Ile  Val Ile Ser Val Ser  Pro Ser Ala 
    2705                 2710                 2715             


Gly Ser  Pro Ser Ala Pro Gly  Ser Ser Met Pro Ile  Arg Ile Glu 
    2720                 2725                 2730             


Ser Ser  Ser Ser His Val Ala  Glu Gly Glu Thr Leu  Asp Leu Asn 
    2735                 2740                 2745             


Cys Val  Val Pro Gly Gln Ala  His Ala Gln Val Thr  Trp His Lys 
    2750                 2755                 2760             


Arg Gly  Gly Ser Leu Pro Ser  His His Gln Thr Arg  Gly Ser Arg 
    2765                 2770                 2775             


Leu Arg  Leu His His Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Val 
    2780                 2785                 2790             


Cys Arg  Val Met Gly Ser Ser  Gly Pro Leu Glu Ala  Ser Val Leu 
    2795                 2800                 2805             


Val Thr  Ile Glu Ala Ser Gly  Ser Ser Ala Val His  Val Pro Ala 
    2810                 2815                 2820             


Pro Gly  Gly Ala Pro Pro Ile  Arg Ile Glu Pro Ser  Ser Ser Arg 
    2825                 2830                 2835             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Lys Cys Val  Val Pro Gly 
    2840                 2845                 2850             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Asn Leu 
    2855                 2860                 2865             


Pro Ala  Arg His Gln Val His  Gly Pro Leu Leu Arg  Leu Asn Gln 
    2870                 2875                 2880             


Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Ser Cys Gln  Val Thr Gly 
    2885                 2890                 2895             


Ser Ser  Gly Thr Leu Glu Ala  Ser Val Leu Val Thr  Ile Glu Pro 
    2900                 2905                 2910             


Ser Ser  Pro Gly Pro Ile Pro  Ala Pro Gly Leu Ala  Gln Pro Ile 
    2915                 2920                 2925             


Tyr Ile  Glu Ala Ser Ser Ser  His Val Thr Glu Gly  Gln Thr Leu 
    2930                 2935                 2940             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ala His Ala  Gln Val Thr 
    2945                 2950                 2955             


Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ala Arg His  Gln Thr His 
    2960                 2965                 2970             


Gly Ser  Gln Leu Arg Leu His  Leu Val Ser Pro Ala  Asp Ser Gly 
    2975                 2980                 2985             


Glu Tyr  Val Cys Arg Ala Ala  Ser Gly Pro Gly Pro  Glu Gln Glu 
    2990                 2995                 3000             


Ala Ser  Phe Thr Val Thr Val  Pro Pro Ser Glu Gly  Ser Ser Tyr 
    3005                 3010                 3015             


Arg Leu  Arg Ser Pro Val Ile  Ser Ile Asp Pro Pro  Ser Ser Thr 
    3020                 3025                 3030             


Val Gln  Gln Gly Gln Asp Ala  Ser Phe Lys Cys Leu  Ile His Asp 
    3035                 3040                 3045             


Gly Ala  Ala Pro Ile Ser Leu  Glu Trp Lys Thr Arg  Asn Gln Glu 
    3050                 3055                 3060             


Leu Glu  Asp Asn Val His Ile  Ser Pro Asn Gly Ser  Ile Ile Thr 
    3065                 3070                 3075             


Ile Val  Gly Thr Arg Pro Ser  Asn His Gly Thr Tyr  Arg Cys Val 
    3080                 3085                 3090             


Ala Ser  Asn Ala Tyr Gly Val  Ala Gln Ser Val Val  Asn Leu Ser 
    3095                 3100                 3105             


Val His  Gly Pro Pro Thr Val  Ser Val Leu Pro Glu  Gly Pro Val 
    3110                 3115                 3120             


Trp Val  Lys Val Gly Lys Ala  Val Thr Leu Glu Cys  Val Ser Ala 
    3125                 3130                 3135             


Gly Glu  Pro Arg Ser Ser Ala  Arg Trp Thr Arg Ile  Ser Ser Thr 
    3140                 3145                 3150             


Pro Ala  Lys Leu Glu Gln Arg  Thr Tyr Gly Leu Met  Asp Ser His 
    3155                 3160                 3165             


Ala Val  Leu Gln Ile Ser Ser  Ala Lys Pro Ser Asp  Ala Gly Thr 
    3170                 3175                 3180             


Tyr Val  Cys Leu Ala Gln Asn  Ala Leu Gly Thr Ala  Gln Lys Gln 
    3185                 3190                 3195             


Val Glu  Val Ile Val Asp Thr  Gly Ala Met Ala Pro  Gly Ala Pro 
    3200                 3205                 3210             


Gln Val  Gln Ala Glu Glu Ala  Glu Leu Thr Val Glu  Ala Gly His 
    3215                 3220                 3225             


Thr Ala  Thr Leu Arg Cys Ser  Ala Thr Gly Ser Pro  Ala Pro Thr 
    3230                 3235                 3240             


Ile His  Trp Ser Lys Leu Arg  Ser Pro Leu Pro Trp  Gln His Arg 
    3245                 3250                 3255             


Leu Glu  Gly Asp Thr Leu Ile  Ile Pro Arg Val Ala  Gln Gln Asp 
    3260                 3265                 3270             


Ser Gly  Gln Tyr Ile Cys Asn  Ala Thr Ser Pro Ala  Gly His Ala 
    3275                 3280                 3285             


Glu Ala  Thr Ile Ile Leu His  Val Glu Ser Pro Pro  Tyr Ala Thr 
    3290                 3295                 3300             


Thr Val  Pro Glu His Ala Ser  Val Gln Ala Gly Glu  Thr Val Gln 
    3305                 3310                 3315             


Leu Gln  Cys Leu Ala His Gly  Thr Pro Pro Leu Thr  Phe Gln Trp 
    3320                 3325                 3330             


Ser Arg  Val Gly Ser Ser Leu  Pro Gly Arg Ala Thr  Ala Arg Asn 
    3335                 3340                 3345             


Glu Leu  Leu His Phe Glu Arg  Ala Ala Pro Glu Asp  Ser Gly Arg 
    3350                 3355                 3360             


Tyr Arg  Cys Arg Val Thr Asn  Lys Val Gly Ser Ala  Glu Ala Phe 
    3365                 3370                 3375             


Ala Gln  Leu Leu Val Gln Gly  Pro Pro Gly Ser Leu  Pro Ala Thr 
    3380                 3385                 3390             


Ser Ile  Pro Ala Gly Ser Thr  Pro Thr Val Gln Val  Thr Pro Gln 
    3395                 3400                 3405             


Leu Glu  Thr Lys Ser Ile Gly  Ala Ser Val Glu Phe  His Cys Ala 
    3410                 3415                 3420             


Val Pro  Ser Asp Arg Gly Thr  Gln Leu Arg Trp Phe  Lys Glu Gly 
    3425                 3430                 3435             


Gly Gln  Leu Pro Pro Gly His  Ser Val Gln Asp Gly  Val Leu Arg 
    3440                 3445                 3450             


Ile Gln  Asn Leu Asp Gln Ser  Cys Gln Gly Thr Tyr  Ile Cys Gln 
    3455                 3460                 3465             


Ala His  Gly Pro Trp Gly Lys  Ala Gln Ala Ser Ala  Gln Leu Val 
    3470                 3475                 3480             


Ile Gln  Ala Leu Pro Ser Val  Leu Ile Asn Ile Arg  Thr Ser Val 
    3485                 3490                 3495             


Gln Thr  Val Val Val Gly His  Ala Val Glu Phe Glu  Cys Leu Ala 
    3500                 3505                 3510             


Leu Gly  Asp Pro Lys Pro Gln  Val Thr Trp Ser Lys  Val Gly Gly 
    3515                 3520                 3525             


His Leu  Arg Pro Gly Ile Val  Gln Ser Gly Gly Val  Val Arg Ile 
    3530                 3535                 3540             


Ala His  Val Glu Leu Ala Asp  Ala Gly Gln Tyr Arg  Cys Thr Ala 
    3545                 3550                 3555             


Thr Asn  Ala Ala Gly Thr Thr  Gln Ser His Val Leu  Leu Leu Val 
    3560                 3565                 3570             


Gln Ala  Leu Pro Gln Ile Ser  Met Pro Gln Glu Val  Arg Val Pro 
    3575                 3580                 3585             


Ala Gly  Ser Ala Ala Val Phe  Pro Cys Ile Ala Ser  Gly Tyr Pro 
    3590                 3595                 3600             


Thr Pro  Asp Ile Ser Trp Ser  Lys Leu Asp Gly Ser  Leu Pro Pro 
    3605                 3610                 3615             


Asp Ser  Arg Leu Glu Asn Asn  Met Leu Met Leu Pro  Ser Val Arg 
    3620                 3625                 3630             


Pro Gln  Asp Ala Gly Thr Tyr  Val Cys Thr Ala Thr  Asn Arg Gln 
    3635                 3640                 3645             


Gly Lys  Val Lys Ala Phe Ala  His Leu Gln Val Pro  Glu Arg Val 
    3650                 3655                 3660             


Val Pro  Tyr Phe Thr Gln Thr  Pro Tyr Ser Phe Leu  Pro Leu Pro 
    3665                 3670                 3675             


Thr Ile  Lys Asp Ala Tyr Arg  Lys Phe Glu Ile Lys  Ile Thr Phe 
    3680                 3685                 3690             


Arg Pro  Asp Ser Ala Asp Gly  Met Leu Leu Tyr Asn  Gly Gln Lys 
    3695                 3700                 3705             


Arg Val  Pro Gly Ser Pro Thr  Asn Leu Ala Asn Arg  Gln Pro Asp 
    3710                 3715                 3720             


Phe Ile  Ser Phe Gly Leu Val  Gly Gly Arg Pro Glu  Phe Arg Phe 
    3725                 3730                 3735             


Asp Ala  Gly Ser Gly Met Ala  Thr Ile Arg His Pro  Thr Pro Leu 
    3740                 3745                 3750             


Ala Leu  Gly His Phe His Thr  Val Thr Leu Leu Arg  Ser Leu Thr 
    3755                 3760                 3765             


Gln Gly  Ser Leu Ile Val Gly  Asp Leu Ala Pro Val  Asn Gly Thr 
    3770                 3775                 3780             


Ser Gln  Gly Lys Phe Gln Gly  Leu Asp Leu Asn Glu  Glu Leu Tyr 
    3785                 3790                 3795             


Leu Gly  Gly Tyr Pro Asp Tyr  Gly Ala Ile Pro Lys  Ala Gly Leu 
    3800                 3805                 3810             


Ser Ser  Gly Phe Ile Gly Cys  Val Arg Glu Leu Arg  Ile Gln Gly 
    3815                 3820                 3825             


Glu Glu  Ile Val Phe His Asp  Leu Asn Leu Thr Ala  His Gly Ile 
    3830                 3835                 3840             


Ser His  Cys Pro Thr Cys Arg  Asp Arg Pro Cys Gln  Asn Gly Gly 
    3845                 3850                 3855             


Gln Cys  His Asp Ser Glu Ser  Ser Ser Tyr Val Cys  Val Cys Pro 
    3860                 3865                 3870             


Ala Gly  Phe Thr Gly Ser Arg  Cys Glu His Ser Gln  Ala Leu His 
    3875                 3880                 3885             


Cys His  Pro Glu Ala Cys Gly  Pro Asp Ala Thr Cys  Val Asn Arg 
    3890                 3895                 3900             


Pro Asp  Gly Arg Gly Tyr Thr  Cys Arg Cys His Leu  Gly Arg Ser 
    3905                 3910                 3915             


Gly Leu  Arg Cys Glu Glu Gly  Val Thr Val Thr Thr  Pro Ser Leu 
    3920                 3925                 3930             


Ser Gly  Ala Gly Ser Tyr Leu  Ala Leu Pro Ala Leu  Thr Asn Thr 
    3935                 3940                 3945             


His His  Glu Leu Arg Leu Asp  Val Glu Phe Lys Pro  Leu Ala Pro 
    3950                 3955                 3960             


Asp Gly  Val Leu Leu Phe Ser  Gly Gly Lys Ser Gly  Pro Val Glu 
    3965                 3970                 3975             


Asp Phe  Val Ser Leu Ala Met  Val Gly Gly His Leu  Glu Phe Arg 
    3980                 3985                 3990             


Tyr Glu  Leu Gly Ser Gly Leu  Ala Val Leu Arg Ser  Ala Glu Pro 
    3995                 4000                 4005             


Leu Ala  Leu Gly Arg Trp His  Arg Val Ser Ala Glu  Arg Leu Asn 
    4010                 4015                 4020             


Lys Asp  Gly Ser Leu Arg Val  Asn Gly Gly Arg Pro  Val Leu Arg 
    4025                 4030                 4035             


Ser Ser  Pro Gly Lys Ser Gln  Gly Leu Asn Leu His  Thr Leu Leu 
    4040                 4045                 4050             


Tyr Leu  Gly Gly Val Glu Pro  Ser Val Pro Leu Ser  Pro Ala Thr 
    4055                 4060                 4065             


Asn Met  Ser Ala His Phe Arg  Gly Cys Val Gly Glu  Val Ser Val 
    4070                 4075                 4080             


Asn Gly  Lys Arg Leu Asp Leu  Thr Tyr Ser Phe Leu  Gly Ser Gln 
    4085                 4090                 4095             


Gly Ile  Gly Gln Cys Tyr Asp  Ser Ser Pro Cys Glu  Arg Gln Pro 
    4100                 4105                 4110             


Cys Gln  His Gly Ala Thr Cys  Met Pro Ala Gly Glu  Tyr Glu Phe 
    4115                 4120                 4125             


Gln Cys  Leu Cys Arg Asp Gly  Phe Lys Gly Asp Leu  Cys Glu His 
    4130                 4135                 4140             


Glu Glu  Asn Pro Cys Gln Leu  Arg Glu Pro Cys Leu  His Gly Gly 
    4145                 4150                 4155             


Thr Cys  Gln Gly Thr Arg Cys  Leu Cys Leu Pro Gly  Phe Ser Gly 
    4160                 4165                 4170             


Pro Arg  Cys Gln Gln Gly Ser  Gly His Gly Ile Ala  Glu Ser Asp 
    4175                 4180                 4185             


Trp His  Leu Glu Gly Ser Gly  Gly Asn Asp Ala Pro  Gly Gln Tyr 
    4190                 4195                 4200             


Gly Ala  Tyr Phe His Asp Asp  Gly Phe Leu Ala Phe  Pro Gly His 
    4205                 4210                 4215             


Val Phe  Ser Arg Ser Leu Pro  Glu Val Pro Glu Thr  Ile Glu Leu 
    4220                 4225                 4230             


Glu Val  Arg Thr Ser Thr Ala  Ser Gly Leu Leu Leu  Trp Gln Gly 
    4235                 4240                 4245             


Val Glu  Val Gly Glu Ala Gly  Gln Gly Lys Asp Phe  Ile Ser Leu 
    4250                 4255                 4260             


Gly Leu  Gln Asp Gly His Leu  Val Phe Arg Tyr Gln  Leu Gly Ser 
    4265                 4270                 4275             


Gly Glu  Ala Arg Leu Val Ser  Glu Asp Pro Ile Asn  Asp Gly Glu 
    4280                 4285                 4290             


Trp His  Arg Val Thr Ala Leu  Arg Glu Gly Arg Arg  Gly Ser Ile 
    4295                 4300                 4305             


Gln Val  Asp Gly Glu Glu Leu  Val Ser Gly Arg Ser  Pro Gly Pro 
    4310                 4315                 4320             


Asn Val  Ala Val Asn Ala Lys  Gly Ser Val Tyr Ile  Gly Gly Ala 
    4325                 4330                 4335             


Pro Asp  Val Ala Thr Leu Thr  Gly Gly Arg Phe Ser  Ser Gly Ile 
    4340                 4345                 4350             


Thr Gly  Cys Val Lys Asn Leu  Val Leu His Ser Ala  Arg Pro Gly 
    4355                 4360                 4365             


Ala Pro  Pro Pro Gln Pro Leu  Asp Leu Gln His Arg  Ala Gln Ala 
    4370                 4375                 4380             


Gly Ala  Asn Thr Arg Pro Cys  Pro Ser 
    4385                 4390         


<210>  5232
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSPH1__Homo_sapiens__NP_001273432

<400>  5232

Met Ser Val Val Gly Leu Asp Val Gly Ser Gln Ser Cys Tyr Ile Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Phe Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ser Val Ile Ser Phe Gly Ser Lys Asn Arg Thr Ile 
        35                  40                  45              


Gly Val Ala Ala Lys Asn Gln Gln Ile Thr His Ala Asn Asn Thr Val 
    50                  55                  60                  


Ser Asn Phe Lys Arg Phe His Gly Arg Ala Phe Asn Asp Pro Phe Ile 
65                  70                  75                  80  


Gln Lys Glu Lys Glu Asn Leu Ser Tyr Asp Leu Val Pro Leu Lys Asn 
                85                  90                  95      


Gly Gly Val Gly Ile Lys Val Met Tyr Met Gly Glu Glu His Leu Phe 
            100                 105                 110         


Ser Val Glu Gln Ile Thr Ala Met Leu Leu Thr Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Asn Ser Leu Lys Lys Pro Val Thr Asp Cys Val Ile Ser Val 
    130                 135                 140                 


Pro Ser Phe Phe Thr Asp Ala Glu Arg Arg Ser Val Leu Asp Ala Ala 
145                 150                 155                 160 


Gln Ile Val Gly Leu Asn Cys Leu Arg Leu Met Asn Asp Met Thr Ala 
                165                 170                 175     


Val Ala Leu Asn Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ser Leu Asp 
            180                 185                 190         


Glu Lys Pro Arg Ile Val Val Phe Val Asp Met Gly His Ser Ala Phe 
        195                 200                 205             


Gln Val Ser Ala Cys Ala Phe Asn Lys Gly Lys Leu Lys Val Leu Gly 
    210                 215                 220                 


Thr Ala Phe Asp Pro Phe Leu Gly Gly Lys Asn Phe Asp Glu Lys Leu 
225                 230                 235                 240 


Val Glu His Phe Cys Ala Glu Phe Lys Thr Lys Tyr Lys Leu Asp Ala 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Tyr Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ser Asn Ser Thr Asp Leu Pro Leu Asn Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Lys Asp Val Ser Gly Lys Met Asn Arg Ser 
    290                 295                 300                 


Gln Phe Glu Glu Leu Cys Ala Glu Leu Leu Gln Lys Ile Glu Val Pro 
305                 310                 315                 320 


Leu Tyr Ser Leu Leu Glu Gln Thr His Leu Lys Val Glu Asp Val Ser 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Arg Ile Ala Lys Phe Phe Gly Lys Asp Ile Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Ala Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Val Thr Asp Ala Val Pro Phe 
385                 390                 395                 400 


Pro Ile Ser Leu Ile Trp Asn His Asp Ser Glu Asp Thr Glu Gly Val 
                405                 410                 415     


His Glu Val Phe Ser Arg Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Leu Arg Arg Gly Pro Phe Glu Leu Glu Ala Phe Tyr Ser Asp 
        435                 440                 445             


Pro Gln Gly Val Pro Tyr Pro Glu Ala Lys Ile Gly Arg Phe Val Val 
    450                 455                 460                 


Gln Asn Val Ser Ala Gln Lys Asp Gly Glu Lys Ser Arg Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Thr His Gly Ile Phe Thr Ile Ser Thr Ala Ser 
                485                 490                 495     


Met Val Glu Lys Val Pro Thr Glu Glu Asn Glu Met Ser Ser Glu Ala 
            500                 505                 510         


Asp Met Glu Cys Leu Asn Gln Arg Pro Pro Glu Asn Pro Asp Thr Asp 
        515                 520                 525             


Ala Asn Glu Lys Lys Val Asp Gln Pro Pro Glu Ala Lys Lys Pro Lys 
    530                 535                 540                 


Ile Lys Val Val Asn Val Glu Leu Pro Ile Glu Ala Asn Leu Val Trp 
545                 550                 555                 560 


Gln Leu Gly Lys Asp Leu Leu Asn Met Tyr Ile Glu Thr Glu Gly Lys 
                565                 570                 575     


Met Ile Met Gln Asp Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn 
            580                 585                 590         


Ala Val Glu Glu Tyr Val Tyr Glu Phe Arg Asp Lys Leu Cys Gly Pro 
        595                 600                 605             


Tyr Glu Lys Phe Ile Cys Glu Gln Asp His Gln Asn Phe Leu Arg Leu 
    610                 615                 620                 


Leu Thr Glu Thr Glu Asp Trp Leu Tyr Glu Glu Gly Glu Asp Gln Ala 
625                 630                 635                 640 


Lys Gln Ala Tyr Val Asp Lys Leu Glu Glu Leu Met Lys Ile Gly Thr 
                645                 650                 655     


Pro Val Lys Val Arg Phe Gln Glu Ala Glu Glu Arg Pro Lys Met Phe 
            660                 665                 670         


Glu Glu Leu Gly Gln Arg Leu Gln His Tyr Ala Lys Ile Ala Ala Asp 
        675                 680                 685             


Phe Arg Asn Lys Asp Glu Lys Tyr Asn His Ile Asp Glu Ser Glu Met 
    690                 695                 700                 


Lys Lys Val Glu Lys Ser Val Asn Glu Val Met Glu Trp Met Asn Asn 
705                 710                 715                 720 


Val Met Asn Ala Gln Ala Lys Lys Ser Leu Asp Gln Asp Pro Val Val 
                725                 730                 735     


Arg Ala Gln Glu Ile Lys Thr Lys Ile Lys Glu Leu Asn Asn Thr Cys 
            740                 745                 750         


Glu Pro Val Val Thr Gln Pro Lys Pro Lys Ile Glu Ser Pro Lys Leu 
        755                 760                 765             


Glu Arg Thr Pro Asn Gly Pro Asn Ile Asp Lys Lys Glu Glu Asp Leu 
    770                 775                 780                 


Glu Asp Lys Asn Asn Phe Gly Ala Glu Pro Pro His Gln Asn Gly Glu 
785                 790                 795                 800 


Cys Tyr Pro Asn Glu Lys Asn Ser Val Asn Met Asp Leu Asp 
                805                 810                 


<210>  5233
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTATIP2__Homo_sapiens__NP_001091990

<400>  5233

Met Ala Gly Pro Ala Ala Leu Ser Ala Ala Ala Ala Ala Ala Leu Ala 
1               5                   10                  15      


Ala Ala Leu Leu Leu Leu Arg Arg Glu Asp Pro Gly Pro Gly Ala Gly 
            20                  25                  30          


Pro Ser Met Ala Glu Thr Glu Ala Leu Ser Lys Leu Arg Glu Asp Phe 
        35                  40                  45              


Arg Met Gln Asn Lys Ser Val Phe Ile Leu Gly Ala Ser Gly Glu Thr 
    50                  55                  60                  


Gly Arg Val Leu Leu Lys Glu Ile Leu Glu Gln Gly Leu Phe Ser Lys 
65                  70                  75                  80  


Val Thr Leu Ile Gly Arg Arg Lys Leu Thr Phe Asp Glu Glu Ala Tyr 
                85                  90                  95      


Lys Asn Val Asn Gln Glu Val Val Asp Phe Glu Lys Leu Asp Asp Tyr 
            100                 105                 110         


Ala Ser Ala Phe Gln Gly His Asp Val Gly Phe Cys Cys Leu Gly Thr 
        115                 120                 125             


Thr Arg Gly Lys Ala Gly Ala Glu Gly Phe Val Arg Val Asp Arg Asp 
    130                 135                 140                 


Tyr Val Leu Lys Ser Ala Glu Leu Ala Lys Ala Gly Gly Cys Lys His 
145                 150                 155                 160 


Phe Asn Leu Leu Ser Ser Lys Gly Ala Asp Lys Ser Ser Asn Phe Leu 
                165                 170                 175     


Tyr Leu Gln Val Lys Gly Glu Val Glu Ala Lys Val Glu Glu Leu Lys 
            180                 185                 190         


Phe Asp Arg Tyr Ser Val Phe Arg Pro Gly Val Leu Leu Cys Asp Arg 
        195                 200                 205             


Gln Glu Ser Arg Pro Gly Glu Trp Leu Val Arg Lys Phe Phe Gly Ser 
    210                 215                 220                 


Leu Pro Asp Ser Trp Ala Ser Gly His Ser Val Pro Val Val Thr Val 
225                 230                 235                 240 


Val Arg Ala Met Leu Asn Asn Val Val Arg Pro Arg Asp Lys Gln Met 
                245                 250                 255     


Glu Leu Leu Glu Asn Lys Ala Ile His Asp Leu Gly Lys Ala His Gly 
            260                 265                 270         


Ser Leu Lys Pro 
        275     


<210>  5234
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTN1__Homo_sapiens__NP_002150

<400>  5234

Met Lys Phe Phe Val Phe Ala Leu Val Leu Ala Leu Met Ile Ser Met 
1               5                   10                  15      


Ile Ser Ala Asp Ser His Glu Lys Arg His His Gly Tyr Arg Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Glu Phe Pro Phe Tyr Gly Asp 
        35                  40                  45              


Tyr Gly Ser Asn Tyr Leu Tyr Asp Asn 
    50                  55          


<210>  5235
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTN3__Homo_sapiens__NP_000191

<400>  5235

Met Lys Phe Phe Val Phe Ala Leu Ile Leu Ala Leu Met Leu Ser Met 
1               5                   10                  15      


Thr Gly Ala Asp Ser His Ala Lys Arg His His Gly Tyr Lys Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Gly Tyr Arg Ser Asn Tyr Leu 
        35                  40                  45              


Tyr Asp Asn 
    50      


<210>  5236
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR1A__Homo_sapiens__NP_000515

<400>  5236

Met Asp Val Leu Ser Pro Gly Gln Gly Asn Asn Thr Thr Ser Pro Pro 
1               5                   10                  15      


Ala Pro Phe Glu Thr Gly Gly Asn Thr Thr Gly Ile Ser Asp Val Thr 
            20                  25                  30          


Val Ser Tyr Gln Val Ile Thr Ser Leu Leu Leu Gly Thr Leu Ile Phe 
        35                  40                  45              


Cys Ala Val Leu Gly Asn Ala Cys Val Val Ala Ala Ile Ala Leu Glu 
    50                  55                  60                  


Arg Ser Leu Gln Asn Val Ala Asn Tyr Leu Ile Gly Ser Leu Ala Val 
65                  70                  75                  80  


Thr Asp Leu Met Val Ser Val Leu Val Leu Pro Met Ala Ala Leu Tyr 
                85                  90                  95      


Gln Val Leu Asn Lys Trp Thr Leu Gly Gln Val Thr Cys Asp Leu Phe 
            100                 105                 110         


Ile Ala Leu Asp Val Leu Cys Cys Thr Ser Ser Ile Leu His Leu Cys 
        115                 120                 125             


Ala Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Pro Ile Asp Tyr 
    130                 135                 140                 


Val Asn Lys Arg Thr Pro Arg Arg Ala Ala Ala Leu Ile Ser Leu Thr 
145                 150                 155                 160 


Trp Leu Ile Gly Phe Leu Ile Ser Ile Pro Pro Met Leu Gly Trp Arg 
                165                 170                 175     


Thr Pro Glu Asp Arg Ser Asp Pro Asp Ala Cys Thr Ile Ser Lys Asp 
            180                 185                 190         


His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro Leu 
        195                 200                 205             


Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg Phe 
    210                 215                 220                 


Arg Ile Arg Lys Thr Val Lys Lys Val Glu Lys Thr Gly Ala Asp Thr 
225                 230                 235                 240 


Arg His Gly Ala Ser Pro Ala Pro Gln Pro Lys Lys Ser Val Asn Gly 
                245                 250                 255     


Glu Ser Gly Ser Arg Asn Trp Arg Leu Gly Val Glu Ser Lys Ala Gly 
            260                 265                 270         


Gly Ala Leu Cys Ala Asn Gly Ala Val Arg Gln Gly Asp Asp Gly Ala 
        275                 280                 285             


Ala Leu Glu Val Ile Glu Val His Arg Val Gly Asn Ser Lys Glu His 
    290                 295                 300                 


Leu Pro Leu Pro Ser Glu Ala Gly Pro Thr Pro Cys Ala Pro Ala Ser 
305                 310                 315                 320 


Phe Glu Arg Lys Asn Glu Arg Asn Ala Glu Ala Lys Arg Lys Met Ala 
                325                 330                 335     


Leu Ala Arg Glu Arg Lys Thr Val Lys Thr Leu Gly Ile Ile Met Gly 
            340                 345                 350         


Thr Phe Ile Leu Cys Trp Leu Pro Phe Phe Ile Val Ala Leu Val Leu 
        355                 360                 365             


Pro Phe Cys Glu Ser Ser Cys His Met Pro Thr Leu Leu Gly Ala Ile 
    370                 375                 380                 


Ile Asn Trp Leu Gly Tyr Ser Asn Ser Leu Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Ala Tyr Phe Asn Lys Asp Phe Gln Asn Ala Phe Lys Lys Ile Ile Lys 
                405                 410                 415     


Cys Lys Phe Cys Arg Gln 
            420         


<210>  5237
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR1B__Homo_sapiens__NP_000854

<400>  5237

Met Glu Glu Pro Gly Ala Gln Cys Ala Pro Pro Pro Pro Ala Gly Ser 
1               5                   10                  15      


Glu Thr Trp Val Pro Gln Ala Asn Leu Ser Ser Ala Pro Ser Gln Asn 
            20                  25                  30          


Cys Ser Ala Lys Asp Tyr Ile Tyr Gln Asp Ser Ile Ser Leu Pro Trp 
        35                  40                  45              


Lys Val Leu Leu Val Met Leu Leu Ala Leu Ile Thr Leu Ala Thr Thr 
    50                  55                  60                  


Leu Ser Asn Ala Phe Val Ile Ala Thr Val Tyr Arg Thr Arg Lys Leu 
65                  70                  75                  80  


His Thr Pro Ala Asn Tyr Leu Ile Ala Ser Leu Ala Val Thr Asp Leu 
                85                  90                  95      


Leu Val Ser Ile Leu Val Met Pro Ile Ser Thr Met Tyr Thr Val Thr 
            100                 105                 110         


Gly Arg Trp Thr Leu Gly Gln Val Val Cys Asp Phe Trp Leu Ser Ser 
        115                 120                 125             


Asp Ile Thr Cys Cys Thr Ala Ser Ile Leu His Leu Cys Val Ile Ala 
    130                 135                 140                 


Leu Asp Arg Tyr Trp Ala Ile Thr Asp Ala Val Glu Tyr Ser Ala Lys 
145                 150                 155                 160 


Arg Thr Pro Lys Arg Ala Ala Val Met Ile Ala Leu Val Trp Val Phe 
                165                 170                 175     


Ser Ile Ser Ile Ser Leu Pro Pro Phe Phe Trp Arg Gln Ala Lys Ala 
            180                 185                 190         


Glu Glu Glu Val Ser Glu Cys Val Val Asn Thr Asp His Ile Leu Tyr 
        195                 200                 205             


Thr Val Tyr Ser Thr Val Gly Ala Phe Tyr Phe Pro Thr Leu Leu Leu 
    210                 215                 220                 


Ile Ala Leu Tyr Gly Arg Ile Tyr Val Glu Ala Arg Ser Arg Ile Leu 
225                 230                 235                 240 


Lys Gln Thr Pro Asn Arg Thr Gly Lys Arg Leu Thr Arg Ala Gln Leu 
                245                 250                 255     


Ile Thr Asp Ser Pro Gly Ser Thr Ser Ser Val Thr Ser Ile Asn Ser 
            260                 265                 270         


Arg Val Pro Asp Val Pro Ser Glu Ser Gly Ser Pro Val Tyr Val Asn 
        275                 280                 285             


Gln Val Lys Val Arg Val Ser Asp Ala Leu Leu Glu Lys Lys Lys Leu 
    290                 295                 300                 


Met Ala Ala Arg Glu Arg Lys Ala Thr Lys Thr Leu Gly Ile Ile Leu 
305                 310                 315                 320 


Gly Ala Phe Ile Val Cys Trp Leu Pro Phe Phe Ile Ile Ser Leu Val 
                325                 330                 335     


Met Pro Ile Cys Lys Asp Ala Cys Trp Phe His Leu Ala Ile Phe Asp 
            340                 345                 350         


Phe Phe Thr Trp Leu Gly Tyr Leu Asn Ser Leu Ile Asn Pro Ile Ile 
        355                 360                 365             


Tyr Thr Met Ser Asn Glu Asp Phe Lys Gln Ala Phe His Lys Leu Ile 
    370                 375                 380                 


Arg Phe Lys Cys Thr Ser 
385                 390 


<210>  5238
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR1E__Homo_sapiens__XP_011534092

<400>  5238

Met Asn Ile Thr Asn Cys Thr Thr Glu Ala Ser Met Ala Ile Arg Pro 
1               5                   10                  15      


Lys Thr Ile Thr Glu Lys Met Leu Ile Cys Met Thr Leu Val Val Ile 
            20                  25                  30          


Thr Thr Leu Thr Thr Leu Leu Asn Leu Ala Val Ile Met Ala Ile Gly 
        35                  40                  45              


Thr Thr Lys Lys Leu His Gln Pro Ala Asn Tyr Leu Ile Cys Ser Leu 
    50                  55                  60                  


Ala Val Thr Asp Leu Leu Val Ala Val Leu Val Met Pro Leu Ser Ile 
65                  70                  75                  80  


Ile Tyr Ile Val Met Asp Arg Trp Lys Leu Gly Tyr Phe Leu Cys Glu 
                85                  90                  95      


Val Trp Leu Ser Val Asp Met Thr Cys Cys Thr Cys Ser Ile Leu His 
            100                 105                 110         


Leu Cys Val Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asn Ala Ile 
        115                 120                 125             


Glu Tyr Ala Arg Lys Arg Thr Ala Lys Arg Ala Ala Leu Met Ile Leu 
    130                 135                 140                 


Thr Val Trp Thr Ile Ser Ile Phe Ile Ser Met Pro Pro Leu Phe Trp 
145                 150                 155                 160 


Arg Ser His Arg Arg Leu Ser Pro Pro Pro Ser Gln Cys Thr Ile Gln 
                165                 170                 175     


His Asp His Val Ile Tyr Thr Ile Tyr Ser Thr Leu Gly Ala Phe Tyr 
            180                 185                 190         


Ile Pro Leu Thr Leu Ile Leu Ile Leu Tyr Tyr Arg Ile Tyr His Ala 
        195                 200                 205             


Ala Lys Ser Leu Tyr Gln Lys Arg Gly Ser Ser Arg His Leu Ser Asn 
    210                 215                 220                 


Arg Ser Thr Asp Ser Gln Asn Ser Phe Ala Ser Cys Lys Leu Thr Gln 
225                 230                 235                 240 


Thr Phe Cys Val Ser Asp Phe Ser Thr Ser Asp Pro Thr Thr Glu Phe 
                245                 250                 255     


Glu Lys Phe His Ala Ser Ile Arg Ile Pro Pro Phe Asp Asn Asp Leu 
            260                 265                 270         


Asp His Pro Gly Glu Arg Gln Gln Ile Ser Ser Thr Arg Glu Arg Lys 
        275                 280                 285             


Ala Ala Arg Ile Leu Gly Leu Ile Leu Gly Ala Phe Ile Leu Ser Trp 
    290                 295                 300                 


Leu Pro Phe Phe Ile Lys Glu Leu Ile Val Gly Leu Ser Ile Tyr Thr 
305                 310                 315                 320 


Val Ser Ser Glu Val Ala Asp Phe Leu Thr Trp Leu Gly Tyr Val Asn 
                325                 330                 335     


Ser Leu Ile Asn Pro Leu Leu Tyr Thr Ser Phe Asn Glu Asp Phe Lys 
            340                 345                 350         


Leu Ala Phe Lys Lys Leu Ile Arg Cys Arg Glu His Thr 
        355                 360                 365 


<210>  5239
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR1F__Homo_sapiens__NP_000857

<400>  5239

Met Asp Phe Leu Asn Ser Ser Asp Gln Asn Leu Thr Ser Glu Glu Leu 
1               5                   10                  15      


Leu Asn Arg Met Pro Ser Lys Ile Leu Val Ser Leu Thr Leu Ser Gly 
            20                  25                  30          


Leu Ala Leu Met Thr Thr Thr Ile Asn Ser Leu Val Ile Ala Ala Ile 
        35                  40                  45              


Ile Val Thr Arg Lys Leu His His Pro Ala Asn Tyr Leu Ile Cys Ser 
    50                  55                  60                  


Leu Ala Val Thr Asp Phe Leu Val Ala Val Leu Val Met Pro Phe Ser 
65                  70                  75                  80  


Ile Val Tyr Ile Val Arg Glu Ser Trp Ile Met Gly Gln Val Val Cys 
                85                  90                  95      


Asp Ile Trp Leu Ser Val Asp Ile Thr Cys Cys Thr Cys Ser Ile Leu 
            100                 105                 110         


His Leu Ser Ala Ile Ala Leu Asp Arg Tyr Arg Ala Ile Thr Asp Ala 
        115                 120                 125             


Val Glu Tyr Ala Arg Lys Arg Thr Pro Lys His Ala Gly Ile Met Ile 
    130                 135                 140                 


Thr Ile Val Trp Ile Ile Ser Val Phe Ile Ser Met Pro Pro Leu Phe 
145                 150                 155                 160 


Trp Arg His Gln Gly Thr Ser Arg Asp Asp Glu Cys Ile Ile Lys His 
                165                 170                 175     


Asp His Ile Val Ser Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile 
            180                 185                 190         


Pro Leu Ala Leu Ile Leu Ile Leu Tyr Tyr Lys Ile Tyr Arg Ala Ala 
        195                 200                 205             


Lys Thr Leu Tyr His Lys Arg Gln Ala Ser Arg Ile Ala Lys Glu Glu 
    210                 215                 220                 


Val Asn Gly Gln Val Leu Leu Glu Ser Gly Glu Lys Ser Thr Lys Ser 
225                 230                 235                 240 


Val Ser Thr Ser Tyr Val Leu Glu Lys Ser Leu Ser Asp Pro Ser Thr 
                245                 250                 255     


Asp Phe Asp Lys Ile His Ser Thr Val Arg Ser Leu Arg Ser Glu Phe 
            260                 265                 270         


Lys His Glu Lys Ser Trp Arg Arg Gln Lys Ile Ser Gly Thr Arg Glu 
        275                 280                 285             


Arg Lys Ala Ala Thr Thr Leu Gly Leu Ile Leu Gly Ala Phe Val Ile 
    290                 295                 300                 


Cys Trp Leu Pro Phe Phe Val Lys Glu Leu Val Val Asn Val Cys Asp 
305                 310                 315                 320 


Lys Cys Lys Ile Ser Glu Glu Met Ser Asn Phe Leu Ala Trp Leu Gly 
                325                 330                 335     


Tyr Leu Asn Ser Leu Ile Asn Pro Leu Ile Tyr Thr Ile Phe Asn Glu 
            340                 345                 350         


Asp Phe Lys Lys Ala Phe Gln Lys Leu Val Arg Cys Arg Cys 
        355                 360                 365     


<210>  5240
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR2A__Homo_sapiens__NP_000612

<400>  5240

Met Asp Ile Leu Cys Glu Glu Asn Thr Ser Leu Ser Ser Thr Thr Asn 
1               5                   10                  15      


Ser Leu Met Gln Leu Asn Asp Asp Thr Arg Leu Tyr Ser Asn Asp Phe 
            20                  25                  30          


Asn Ser Gly Glu Ala Asn Thr Ser Asp Ala Phe Asn Trp Thr Val Asp 
        35                  40                  45              


Ser Glu Asn Arg Thr Asn Leu Ser Cys Glu Gly Cys Leu Ser Pro Ser 
    50                  55                  60                  


Cys Leu Ser Leu Leu His Leu Gln Glu Lys Asn Trp Ser Ala Leu Leu 
65                  70                  75                  80  


Thr Ala Val Val Ile Ile Leu Thr Ile Ala Gly Asn Ile Leu Val Ile 
                85                  90                  95      


Met Ala Val Ser Leu Glu Lys Lys Leu Gln Asn Ala Thr Asn Tyr Phe 
            100                 105                 110         


Leu Met Ser Leu Ala Ile Ala Asp Met Leu Leu Gly Phe Leu Val Met 
        115                 120                 125             


Pro Val Ser Met Leu Thr Ile Leu Tyr Gly Tyr Arg Trp Pro Leu Pro 
    130                 135                 140                 


Ser Lys Leu Cys Ala Val Trp Ile Tyr Leu Asp Val Leu Phe Ser Thr 
145                 150                 155                 160 


Ala Ser Ile Met His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala 
                165                 170                 175     


Ile Gln Asn Pro Ile His His Ser Arg Phe Asn Ser Arg Thr Lys Ala 
            180                 185                 190         


Phe Leu Lys Ile Ile Ala Val Trp Thr Ile Ser Val Gly Ile Ser Met 
        195                 200                 205             


Pro Ile Pro Val Phe Gly Leu Gln Asp Asp Ser Lys Val Phe Lys Glu 
    210                 215                 220                 


Gly Ser Cys Leu Leu Ala Asp Asp Asn Phe Val Leu Ile Gly Ser Phe 
225                 230                 235                 240 


Val Ser Phe Phe Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Phe Leu 
                245                 250                 255     


Thr Ile Lys Ser Leu Gln Lys Glu Ala Thr Leu Cys Val Ser Asp Leu 
            260                 265                 270         


Gly Thr Arg Ala Lys Leu Ala Ser Phe Ser Phe Leu Pro Gln Ser Ser 
        275                 280                 285             


Leu Ser Ser Glu Lys Leu Phe Gln Arg Ser Ile His Arg Glu Pro Gly 
    290                 295                 300                 


Ser Tyr Thr Gly Arg Arg Thr Met Gln Ser Ile Ser Asn Glu Gln Lys 
305                 310                 315                 320 


Ala Cys Lys Val Leu Gly Ile Val Phe Phe Leu Phe Val Val Met Trp 
                325                 330                 335     


Cys Pro Phe Phe Ile Thr Asn Ile Met Ala Val Ile Cys Lys Glu Ser 
            340                 345                 350         


Cys Asn Glu Asp Val Ile Gly Ala Leu Leu Asn Val Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Leu Ser Ser Ala Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Tyr Arg Ser Ala Phe Ser Arg Tyr Ile Gln Cys Gln Tyr Lys 
385                 390                 395                 400 


Glu Asn Lys Lys Pro Leu Gln Leu Ile Leu Val Asn Thr Ile Pro Ala 
                405                 410                 415     


Leu Ala Tyr Lys Ser Ser Gln Leu Gln Met Gly Gln Lys Lys Asn Ser 
            420                 425                 430         


Lys Gln Asp Ala Lys Thr Thr Asp Asn Asp Cys Ser Met Val Ala Leu 
        435                 440                 445             


Gly Lys Gln His Ser Glu Glu Ala Ser Lys Asp Asn Ser Asp Gly Val 
    450                 455                 460                 


Asn Glu Lys Val Ser Cys Val 
465                 470     


<210>  5241
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR2B__Homo_sapiens__NP_000858

<400>  5241

Met Ala Leu Ser Tyr Arg Val Ser Glu Leu Gln Ser Thr Ile Pro Glu 
1               5                   10                  15      


His Ile Leu Gln Ser Thr Phe Val His Val Ile Ser Ser Asn Trp Ser 
            20                  25                  30          


Gly Leu Gln Thr Glu Ser Ile Pro Glu Glu Met Lys Gln Ile Val Glu 
        35                  40                  45              


Glu Gln Gly Asn Lys Leu His Trp Ala Ala Leu Leu Ile Leu Met Val 
    50                  55                  60                  


Ile Ile Pro Thr Ile Gly Gly Asn Thr Leu Val Ile Leu Ala Val Ser 
65                  70                  75                  80  


Leu Glu Lys Lys Leu Gln Tyr Ala Thr Asn Tyr Phe Leu Met Ser Leu 
                85                  90                  95      


Ala Val Ala Asp Leu Leu Val Gly Leu Phe Val Met Pro Ile Ala Leu 
            100                 105                 110         


Leu Thr Ile Met Phe Glu Ala Met Trp Pro Leu Pro Leu Val Leu Cys 
        115                 120                 125             


Pro Ala Trp Leu Phe Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met 
    130                 135                 140                 


His Leu Cys Ala Ile Ser Val Asp Arg Tyr Ile Ala Ile Lys Lys Pro 
145                 150                 155                 160 


Ile Gln Ala Asn Gln Tyr Asn Ser Arg Ala Thr Ala Phe Ile Lys Ile 
                165                 170                 175     


Thr Val Val Trp Leu Ile Ser Ile Gly Ile Ala Ile Pro Val Pro Ile 
            180                 185                 190         


Lys Gly Ile Glu Thr Asp Val Asp Asn Pro Asn Asn Ile Thr Cys Val 
        195                 200                 205             


Leu Thr Lys Glu Arg Phe Gly Asp Phe Met Leu Phe Gly Ser Leu Ala 
    210                 215                 220                 


Ala Phe Phe Thr Pro Leu Ala Ile Met Ile Val Thr Tyr Phe Leu Thr 
225                 230                 235                 240 


Ile His Ala Leu Gln Lys Lys Ala Tyr Leu Val Lys Asn Lys Pro Pro 
                245                 250                 255     


Gln Arg Leu Thr Trp Leu Thr Val Ser Thr Val Phe Gln Arg Asp Glu 
            260                 265                 270         


Thr Pro Cys Ser Ser Pro Glu Lys Val Ala Met Leu Asp Gly Ser Arg 
        275                 280                 285             


Lys Asp Lys Ala Leu Pro Asn Ser Gly Asp Glu Thr Leu Met Arg Arg 
    290                 295                 300                 


Thr Ser Thr Ile Gly Lys Lys Ser Val Gln Thr Ile Ser Asn Glu Gln 
305                 310                 315                 320 


Arg Ala Ser Lys Val Leu Gly Ile Val Phe Phe Leu Phe Leu Leu Met 
                325                 330                 335     


Trp Cys Pro Phe Phe Ile Thr Asn Ile Thr Leu Val Leu Cys Asp Ser 
            340                 345                 350         


Cys Asn Gln Thr Thr Leu Gln Met Leu Leu Glu Ile Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Val Ser Ser Gly Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Phe Arg Asp Ala Phe Gly Arg Tyr Ile Thr Cys Asn Tyr Arg 
385                 390                 395                 400 


Ala Thr Lys Ser Val Lys Thr Leu Arg Lys Arg Ser Ser Lys Ile Tyr 
                405                 410                 415     


Phe Arg Asn Pro Met Ala Glu Asn Ser Lys Phe Phe Lys Lys His Gly 
            420                 425                 430         


Ile Arg Asn Gly Ile Asn Pro Ala Met Tyr Gln Ser Pro Met Arg Leu 
        435                 440                 445             


Arg Ser Ser Thr Ile Gln Ser Ser Ser Ile Ile Leu Leu Asp Thr Leu 
    450                 455                 460                 


Leu Leu Thr Glu Asn Glu Gly Asp Lys Thr Glu Glu Gln Val Ser Tyr 
465                 470                 475                 480 


Val 
    


<210>  5242
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR2C__Homo_sapiens__NP_001243689

<400>  5242

Met Val Asn Leu Arg Asn Ala Val His Ser Phe Leu Val His Leu Ile 
1               5                   10                  15      


Gly Leu Leu Val Trp Gln Cys Asp Ile Ser Val Ser Pro Val Ala Ala 
            20                  25                  30          


Ile Val Thr Asp Ile Phe Asn Thr Ser Asp Gly Gly Arg Phe Lys Phe 
        35                  40                  45              


Pro Asp Gly Val Gln Asn Trp Pro Ala Leu Ser Ile Val Ile Ile Ile 
    50                  55                  60                  


Ile Met Thr Ile Gly Gly Asn Ile Leu Val Ile Met Ala Val Ser Met 
65                  70                  75                  80  


Glu Lys Lys Leu His Asn Ala Thr Asn Tyr Phe Leu Met Ser Leu Ala 
                85                  90                  95      


Ile Ala Asp Met Leu Val Gly Leu Leu Val Met Pro Leu Ser Leu Leu 
            100                 105                 110         


Ala Ile Leu Tyr Asp Tyr Val Trp Pro Leu Pro Arg Tyr Leu Cys Pro 
        115                 120                 125             


Val Trp Ile Ser Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met His 
    130                 135                 140                 


Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala Ile Arg Asn Pro Ile 
145                 150                 155                 160 


Glu His Ser Arg Phe Asn Ser Arg Thr Lys Ala Ile Met Lys Ile Ala 
                165                 170                 175     


Ile Val Trp Ala Ile Ser Ile Gly Val Ser Val Pro Ile Pro Val Ile 
            180                 185                 190         


Gly Leu Arg Asp Glu Glu Lys Val Phe Val Asn Asn Thr Thr Cys Val 
        195                 200                 205             


Leu Asn Asp Pro Asn Phe Val Leu Ile Gly Ser Phe Val Ala Phe Phe 
    210                 215                 220                 


Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Cys Leu Thr Ile Tyr Val 
225                 230                 235                 240 


Leu Arg Arg Gln Ala Leu Met Leu Leu His Gly His Thr Glu Glu Pro 
                245                 250                 255     


Pro Gly Leu Ser Leu Asp Phe Leu Lys Cys Cys Lys Arg Asn Thr Ala 
            260                 265                 270         


Glu Glu Glu Asn Ser Ala Asn Pro Asn Gln Asp Gln Asn Ala Arg Arg 
        275                 280                 285             


Arg Lys Lys Lys Glu Arg Arg Pro Arg Gly Thr Met Gln Ala Ile Asn 
    290                 295                 300                 


Asn Glu Arg Lys Ala Ser Lys Val Leu Gly Ile Val Phe Phe Val Phe 
305                 310                 315                 320 


Leu Ile Met Trp Cys Pro Phe Phe Ile Thr Asn Ile Leu Ser Val Leu 
                325                 330                 335     


Cys Glu Lys Ser Cys Asn Gln Lys Leu Met Glu Lys Leu Leu Asn Val 
            340                 345                 350         


Phe Val Trp Ile Gly Tyr Val Cys Ser Gly Ile Asn Pro Leu Val Tyr 
        355                 360                 365             


Thr Leu Phe Asn Lys Ile Tyr Arg Arg Ala Phe Ser Asn Tyr Leu Arg 
    370                 375                 380                 


Cys Asn Tyr Lys Val Glu Lys Lys Pro Pro Val Arg Gln Ile Pro Arg 
385                 390                 395                 400 


Val Ala Ala Thr Ala Leu Ser Gly Arg Glu Leu Asn Val Asn Ile Tyr 
                405                 410                 415     


Arg His Thr Asn Glu Pro Val Ile Glu Lys Ala Ser Asp Asn Glu Pro 
            420                 425                 430         


Gly Ile Glu Met Gln Val Glu Asn Leu Glu Leu Pro Val Asn Pro Ser 
        435                 440                 445             


Ser Val Val Ser Glu Arg Ile Ser Ser Val 
    450                 455             


<210>  5243
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR3A__Homo_sapiens__NP_000860

<400>  5243

Met Leu Gly Lys Leu Ala Met Leu Leu Trp Val Gln Gln Ala Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser 
            20                  25                  30          


Arg Asn Thr Thr Arg Pro Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu 
        35                  40                  45              


Thr Asn Tyr Arg Lys Gly Val Arg Pro Val Arg Asp Trp Arg Lys Pro 
    50                  55                  60                  


Thr Thr Val Ser Ile Asp Val Ile Val Tyr Ala Ile Leu Asn Val Asp 
65                  70                  75                  80  


Glu Lys Asn Gln Val Leu Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp 
                85                  90                  95      


Thr Asp Glu Phe Leu Gln Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr 
            100                 105                 110         


Lys Leu Ser Ile Pro Thr Asp Ser Ile Trp Val Pro Asp Ile Leu Ile 
        115                 120                 125             


Asn Glu Phe Val Asp Val Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr 
    130                 135                 140                 


Ile Arg His Gln Gly Glu Val Gln Asn Tyr Lys Pro Leu Gln Val Val 
145                 150                 155                 160 


Thr Ala Cys Ser Leu Asp Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn 
                165                 170                 175     


Cys Ser Leu Thr Phe Thr Ser Trp Leu His Thr Ile Gln Asp Ile Asn 
            180                 185                 190         


Ile Ser Leu Trp Arg Leu Pro Glu Lys Val Lys Ser Asp Arg Ser Val 
        195                 200                 205             


Phe Met Asn Gln Gly Glu Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe 
    210                 215                 220                 


Arg Glu Phe Ser Met Glu Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe 
225                 230                 235                 240 


Tyr Val Val Ile Arg Arg Arg Pro Leu Phe Tyr Val Val Ser Leu Leu 
                245                 250                 255     


Leu Pro Ser Ile Phe Leu Met Val Met Asp Ile Val Gly Phe Tyr Leu 
            260                 265                 270         


Pro Pro Asn Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu 
        275                 280                 285             


Gly Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr 
    290                 295                 300                 


Ala Ile Gly Thr Pro Leu Ile Gly Val Tyr Phe Val Val Cys Met Ala 
305                 310                 315                 320 


Leu Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Arg Leu Val 
                325                 330                 335     


His Lys Gln Asp Leu Gln Gln Pro Val Pro Ala Trp Leu Arg His Leu 
            340                 345                 350         


Val Leu Glu Arg Ile Ala Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr 
        355                 360                 365             


Ser Gln Arg Pro Pro Ala Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys 
    370                 375                 380                 


Ser Ala Met Gly Asn His Cys Ser His Met Gly Gly Pro Gln Asp Phe 
385                 390                 395                 400 


Glu Lys Ser Pro Arg Asp Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu 
                405                 410                 415     


Ala Ser Leu Ala Val Cys Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg 
            420                 425                 430         


Gln Phe Leu Glu Lys Arg Asp Glu Ile Arg Glu Val Ala Arg Asp Trp 
        435                 440                 445             


Leu Arg Val Gly Ser Val Leu Asp Lys Leu Leu Phe His Ile Tyr Leu 
    450                 455                 460                 


Leu Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Met Leu Trp Ser Ile 
465                 470                 475                 480 


Trp Gln Tyr Ala 
                


<210>  5244
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR3B__Homo_sapiens__NP_006019

<400>  5244

Met Leu Ser Ser Val Met Ala Pro Leu Trp Ala Cys Ile Leu Val Ala 
1               5                   10                  15      


Ala Gly Ile Leu Ala Thr Asp Thr His His Pro Gln Asp Ser Ala Leu 
            20                  25                  30          


Tyr His Leu Ser Lys Gln Leu Leu Gln Lys Tyr His Lys Glu Val Arg 
        35                  40                  45              


Pro Val Tyr Asn Trp Thr Lys Ala Thr Thr Val Tyr Leu Asp Leu Phe 
    50                  55                  60                  


Val His Ala Ile Leu Asp Val Asp Ala Glu Asn Gln Ile Leu Lys Thr 
65                  70                  75                  80  


Ser Val Trp Tyr Gln Glu Val Trp Asn Asp Glu Phe Leu Ser Trp Asn 
                85                  90                  95      


Ser Ser Met Phe Asp Glu Ile Arg Glu Ile Ser Leu Pro Leu Ser Ala 
            100                 105                 110         


Ile Trp Ala Pro Asp Ile Ile Ile Asn Glu Phe Val Asp Ile Glu Arg 
        115                 120                 125             


Tyr Pro Asp Leu Pro Tyr Val Tyr Val Asn Ser Ser Gly Thr Ile Glu 
    130                 135                 140                 


Asn Tyr Lys Pro Ile Gln Val Val Ser Ala Cys Ser Leu Glu Thr Tyr 
145                 150                 155                 160 


Ala Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Lys Ser Ile 
                165                 170                 175     


Leu His Thr Val Glu Asp Val Asp Leu Ala Phe Leu Arg Ser Pro Glu 
            180                 185                 190         


Asp Ile Gln His Asp Lys Lys Ala Phe Leu Asn Asp Ser Glu Trp Glu 
        195                 200                 205             


Leu Leu Ser Val Ser Ser Thr Tyr Ser Ile Leu Gln Ser Ser Ala Gly 
    210                 215                 220                 


Gly Phe Ala Gln Ile Gln Phe Asn Val Val Met Arg Arg His Pro Leu 
225                 230                 235                 240 


Val Tyr Val Val Ser Leu Leu Ile Pro Ser Ile Phe Leu Met Leu Val 
                245                 250                 255     


Asp Leu Gly Ser Phe Tyr Leu Pro Pro Asn Cys Arg Ala Arg Ile Val 
            260                 265                 270         


Phe Lys Thr Ser Val Leu Val Gly Tyr Thr Val Phe Arg Val Asn Met 
        275                 280                 285             


Ser Asn Gln Val Pro Arg Ser Val Gly Ser Thr Pro Leu Ile Gly His 
    290                 295                 300                 


Phe Phe Thr Ile Cys Met Ala Phe Leu Val Leu Ser Leu Ala Lys Ser 
305                 310                 315                 320 


Ile Val Leu Val Lys Phe Leu His Asp Glu Gln Arg Gly Gly Gln Glu 
                325                 330                 335     


Gln Pro Phe Leu Cys Leu Arg Gly Asp Thr Asp Ala Asp Arg Pro Arg 
            340                 345                 350         


Val Glu Pro Arg Ala Gln Arg Ala Val Val Thr Glu Ser Ser Leu Tyr 
        355                 360                 365             


Gly Glu His Leu Ala Gln Pro Gly Thr Leu Lys Glu Val Trp Ser Gln 
    370                 375                 380                 


Leu Gln Ser Ile Ser Asn Tyr Leu Gln Thr Gln Asp Gln Thr Asp Gln 
385                 390                 395                 400 


Gln Glu Ala Glu Trp Leu Val Leu Leu Ser Arg Phe Asp Arg Leu Leu 
                405                 410                 415     


Phe Gln Ser Tyr Leu Phe Met Leu Gly Ile Tyr Thr Ile Thr Leu Cys 
            420                 425                 430         


Ser Leu Trp Ala Leu Trp Gly Gly Val 
        435                 440     


<210>  5245
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR3C__Homo_sapiens__NP_570126

<400>  5245

Met Glu Gly Gly Trp Pro Ala Arg Gln Ser Ala Leu Leu Cys Leu Thr 
1               5                   10                  15      


Val Ser Leu Leu Leu Gln Gly Arg Gly Asp Ala Phe Thr Ile Asn Cys 
            20                  25                  30          


Ser Gly Phe Asp Gln His Gly Val Asp Pro Ala Val Phe Gln Ala Val 
        35                  40                  45              


Phe Asp Arg Lys Ala Phe Arg Pro Phe Thr Asn Tyr Ser Ile Pro Thr 
    50                  55                  60                  


Arg Val Asn Ile Ser Phe Thr Leu Ser Ala Ile Leu Gly Val Asp Ala 
65                  70                  75                  80  


Gln Leu Gln Leu Leu Thr Ser Phe Leu Trp Met Asp Leu Val Trp Asp 
                85                  90                  95      


Asn Pro Phe Ile Asn Trp Asn Pro Lys Glu Cys Val Gly Ile Asn Lys 
            100                 105                 110         


Leu Thr Val Leu Ala Glu Asn Leu Trp Leu Pro Asp Ile Phe Ile Val 
        115                 120                 125             


Glu Ser Met Asp Val Asp Gln Thr Pro Ser Gly Leu Thr Ala Tyr Ile 
    130                 135                 140                 


Ser Ser Glu Gly Arg Ile Lys Tyr Asp Lys Pro Met Arg Val Thr Ser 
145                 150                 155                 160 


Ile Cys Asn Leu Asp Ile Phe Tyr Phe Pro Phe Asp Gln Gln Asn Cys 
                165                 170                 175     


Thr Phe Thr Phe Ser Ser Phe Leu Tyr Thr Val Asp Ser Met Leu Leu 
            180                 185                 190         


Gly Met Asp Lys Glu Val Trp Glu Ile Thr Asp Thr Ser Arg Lys Val 
        195                 200                 205             


Ile Gln Thr Gln Gly Glu Trp Glu Leu Leu Gly Ile Asn Lys Ala Thr 
    210                 215                 220                 


Pro Lys Met Ser Met Gly Asn Asn Leu Tyr Asp Gln Ile Met Phe Tyr 
225                 230                 235                 240 


Val Ala Ile Arg Arg Arg Pro Ser Leu Tyr Ile Ile Asn Leu Leu Val 
                245                 250                 255     


Pro Ser Ser Phe Leu Val Ala Ile Asp Ala Leu Ser Phe Tyr Leu Pro 
            260                 265                 270         


Ala Glu Ser Glu Asn Arg Ala Pro Phe Lys Ile Thr Leu Leu Leu Gly 
        275                 280                 285             


Tyr Asn Val Phe Leu Leu Met Met Asn Asp Leu Leu Pro Ala Ser Gly 
    290                 295                 300                 


Thr Pro Leu Ile Ser Val Tyr Phe Ala Leu Cys Leu Ser Leu Met Val 
305                 310                 315                 320 


Val Ser Leu Leu Glu Thr Val Phe Ile Thr Tyr Leu Leu His Val Ala 
                325                 330                 335     


Thr Thr Gln Pro Pro Pro Met Pro Arg Trp Leu His Ser Leu Leu Leu 
            340                 345                 350         


His Cys Thr Ser Pro Gly Arg Cys Cys Pro Thr Ala Pro Gln Lys Gly 
        355                 360                 365             


Asn Lys Gly Leu Gly Leu Thr Leu Thr His Leu Pro Gly Pro Lys Glu 
    370                 375                 380                 


Pro Gly Glu Leu Ala Gly Lys Lys Leu Gly Pro Arg Glu Thr Glu Pro 
385                 390                 395                 400 


Asp Gly Gly Ser Gly Trp Thr Lys Thr Gln Leu Met Glu Leu Trp Val 
                405                 410                 415     


Gln Phe Ser His Ala Met Asp Thr Leu Leu Phe Arg Leu Tyr Leu Leu 
            420                 425                 430         


Phe Met Ala Ser Ser Ile Leu Thr Val Ile Val Leu Trp Asn Thr 
        435                 440                 445         


<210>  5246
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR3D__Homo_sapiens__NP_001138615

<400>  5246

Met Glu Arg Gly Trp Phe His Gly Lys Gly Phe Leu Leu Gly Phe Ile 
1               5                   10                  15      


Leu His Leu Leu Leu Gln Asp Ser His Leu Gln Leu Val Thr Ser Phe 
            20                  25                  30          


Leu Trp Leu Asn Met Trp Asn Pro Asp Glu Cys Gly Gly Ile Lys Lys 
        35                  40                  45              


Ser Gly Met Ala Thr Glu Asn Leu Trp Leu Ser Asp Val Phe Ile Glu 
    50                  55                  60                  


Glu Ser Val Asp Gln Thr Pro Ala Gly Leu Met Ala Ser Met Ser Ile 
65                  70                  75                  80  


Val Lys Ala Thr Ser Asn Thr Ile Ser Gln Cys Gly Trp Ser Ala Ser 
                85                  90                  95      


Ala Asn Trp Thr Pro Ser Ile Ser Pro Ser Met Asp Arg Gly Glu Arg 
            100                 105                 110         


Ser Pro Ser Ala Leu Ser Pro Thr Gln Val Thr Arg Ala Trp Arg Arg 
        115                 120                 125             


Met Ser Arg Ser Phe Gln Ile His His Arg Thr Ser Phe Arg Thr Arg 
    130                 135                 140                 


Arg Glu Trp Val Leu Leu Gly Ile Gln Lys Arg Thr Ile Lys Val Thr 
145                 150                 155                 160 


Val Ala Thr Asn Gln Tyr Glu Gln Ala Ile Phe His Val Ala Ile Arg 
                165                 170                 175     


Arg Arg Cys Arg Pro Ser Pro Tyr Val Val Asn Phe Leu Val Pro Ser 
            180                 185                 190         


Gly Ile Leu Ile Ala Ile Asp Ala Leu Ser Phe Tyr Leu Pro Leu Glu 
        195                 200                 205             


Ser Gly Asn Cys Ala Pro Phe Lys Met Thr Val Leu Leu Gly Tyr Ser 
    210                 215                 220                 


Val Phe Leu Leu Met Met Asn Asp Leu Leu Pro Ala Thr Ser Thr Ser 
225                 230                 235                 240 


Ser His Ala Ser Leu Val Arg Pro His Pro Ser Arg Asp Gln Lys Arg 
                245                 250                 255     


Gly Val Tyr Phe Ala Leu Cys Leu Ser Leu Met Val Gly Ser Leu Leu 
            260                 265                 270         


Glu Thr Ile Phe Ile Thr His Leu Leu His Val Ala Thr Thr Gln Pro 
        275                 280                 285             


Leu Pro Leu Pro Arg Trp Leu His Ser Leu Leu Leu His Cys Thr Gly 
    290                 295                 300                 


Gln Gly Arg Cys Cys Pro Thr Ala Pro Gln Lys Gly Asn Lys Gly Pro 
305                 310                 315                 320 


Gly Leu Thr Pro Thr His Leu Pro Gly Val Lys Glu Pro Glu Val Ser 
                325                 330                 335     


Ala Gly Gln Met Pro Gly Pro Gly Glu Ala Glu Leu Thr Gly Gly Ser 
            340                 345                 350         


Glu Trp Thr Arg Ala Gln Arg Glu His Glu Ala Gln Lys Gln His Ser 
        355                 360                 365             


Val Glu Leu Trp Val Gln Phe Ser His Ala Met Asp Ala Leu Leu Phe 
    370                 375                 380                 


Arg Leu Tyr Leu Leu Phe Met Ala Ser Ser Ile Ile Thr Val Ile Cys 
385                 390                 395                 400 


Leu Trp Asn Thr 
                


<210>  5247
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR3E__Homo_sapiens__NP_001243542

<400>  5247

Met Glu Gly Ser Trp Phe His Arg Lys Arg Phe Ser Phe Tyr Leu Leu 
1               5                   10                  15      


Leu Gly Phe Leu Leu Gln Gly Arg Gly Val Thr Phe Thr Ile Asn Cys 
            20                  25                  30          


Ser Gly Phe Gly Gln His Gly Ala Asp Pro Thr Ala Leu Asn Ser Val 
        35                  40                  45              


Phe Asn Arg Lys Pro Phe Arg Pro Val Thr Asn Ile Ser Val Pro Thr 
    50                  55                  60                  


Gln Val Asn Ile Ser Phe Ala Met Ser Ala Ile Leu Asp Val Asn Glu 
65                  70                  75                  80  


Gln Leu His Leu Leu Ser Ser Phe Leu Trp Leu Glu Met Val Trp Asp 
                85                  90                  95      


Asn Pro Phe Ile Ser Trp Asn Pro Glu Glu Cys Glu Gly Ile Thr Lys 
            100                 105                 110         


Met Ser Met Ala Ala Lys Asn Leu Trp Leu Pro Asp Ile Phe Ile Ile 
        115                 120                 125             


Glu Leu Met Asp Val Asp Lys Thr Pro Lys Gly Leu Thr Ala Tyr Val 
    130                 135                 140                 


Ser Asn Glu Gly Arg Ile Arg Tyr Lys Lys Pro Met Lys Val Asp Ser 
145                 150                 155                 160 


Ile Cys Asn Leu Asp Ile Phe Tyr Phe Pro Phe Asp Gln Gln Asn Cys 
                165                 170                 175     


Thr Leu Thr Phe Ser Ser Phe Leu Tyr Thr Val Asp Ser Met Leu Leu 
            180                 185                 190         


Asp Met Glu Lys Glu Val Trp Glu Ile Thr Asp Ala Ser Arg Asn Ile 
        195                 200                 205             


Leu Gln Thr His Gly Glu Trp Glu Leu Leu Gly Leu Ser Lys Ala Thr 
    210                 215                 220                 


Ala Lys Leu Ser Arg Gly Gly Asn Leu Tyr Asp Gln Ile Val Phe Tyr 
225                 230                 235                 240 


Val Ala Ile Arg Arg Arg Pro Ser Leu Tyr Val Ile Asn Leu Leu Val 
                245                 250                 255     


Pro Ser Gly Phe Leu Val Ala Ile Asp Ala Leu Ser Phe Tyr Leu Pro 
            260                 265                 270         


Val Lys Ser Gly Asn Arg Val Pro Phe Lys Ile Thr Leu Leu Leu Gly 
        275                 280                 285             


Tyr Asn Val Phe Leu Leu Met Met Ser Asp Leu Leu Pro Thr Ser Gly 
    290                 295                 300                 


Thr Pro Leu Ile Gly Val Tyr Phe Ala Leu Cys Leu Ser Leu Met Val 
305                 310                 315                 320 


Gly Ser Leu Leu Glu Thr Ile Phe Ile Thr His Leu Leu His Val Ala 
                325                 330                 335     


Thr Thr Gln Pro Pro Pro Leu Pro Arg Trp Leu His Ser Leu Leu Leu 
            340                 345                 350         


His Cys Asn Ser Pro Gly Arg Cys Cys Pro Thr Ala Pro Gln Lys Glu 
        355                 360                 365             


Asn Lys Gly Pro Gly Leu Thr Pro Thr His Leu Pro Gly Val Lys Glu 
    370                 375                 380                 


Pro Glu Val Ser Ala Gly Gln Met Pro Gly Pro Ala Glu Ala Glu Leu 
385                 390                 395                 400 


Thr Gly Gly Ser Glu Trp Thr Arg Ala Gln Arg Glu His Glu Ala Gln 
                405                 410                 415     


Lys Gln His Ser Val Glu Leu Trp Leu Gln Phe Ser His Ala Met Asp 
            420                 425                 430         


Ala Met Leu Phe Arg Leu Tyr Leu Leu Phe Met Ala Ser Ser Ile Ile 
        435                 440                 445             


Thr Val Ile Cys Leu Trp Asn Thr 
    450                 455     


<210>  5248
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR4__Homo_sapiens__NP_000861

<400>  5248

Met Asp Lys Leu Asp Ala Asn Val Ser Ser Glu Glu Gly Phe Gly Ser 
1               5                   10                  15      


Val Glu Lys Val Val Leu Leu Thr Phe Leu Ser Thr Val Ile Leu Met 
            20                  25                  30          


Ala Ile Leu Gly Asn Leu Leu Val Met Val Ala Val Cys Trp Asp Arg 
        35                  40                  45              


Gln Leu Arg Lys Ile Lys Thr Asn Tyr Phe Ile Val Ser Leu Ala Phe 
    50                  55                  60                  


Ala Asp Leu Leu Val Ser Val Leu Val Met Pro Phe Gly Ala Ile Glu 
65                  70                  75                  80  


Leu Val Gln Asp Ile Trp Ile Tyr Gly Glu Val Phe Cys Leu Val Arg 
                85                  90                  95      


Thr Ser Leu Asp Val Leu Leu Thr Thr Ala Ser Ile Phe His Leu Cys 
            100                 105                 110         


Cys Ile Ser Leu Asp Arg Tyr Tyr Ala Ile Cys Cys Gln Pro Leu Val 
        115                 120                 125             


Tyr Arg Asn Lys Met Thr Pro Leu Arg Ile Ala Leu Met Leu Gly Gly 
    130                 135                 140                 


Cys Trp Val Ile Pro Thr Phe Ile Ser Phe Leu Pro Ile Met Gln Gly 
145                 150                 155                 160 


Trp Asn Asn Ile Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn 
                165                 170                 175     


Gln Asn Ser Asn Ser Thr Tyr Cys Val Phe Met Val Asn Lys Pro Tyr 
            180                 185                 190         


Ala Ile Thr Cys Ser Val Val Ala Phe Tyr Ile Pro Phe Leu Leu Met 
        195                 200                 205             


Val Leu Ala Tyr Tyr Arg Ile Tyr Val Thr Ala Lys Glu His Ala His 
    210                 215                 220                 


Gln Ile Gln Met Leu Gln Arg Ala Gly Ala Ser Ser Glu Ser Arg Pro 
225                 230                 235                 240 


Gln Ser Ala Asp Gln His Ser Thr His Arg Met Arg Thr Glu Thr Lys 
                245                 250                 255     


Ala Ala Lys Thr Leu Cys Ile Ile Met Gly Cys Phe Cys Leu Cys Trp 
            260                 265                 270         


Ala Pro Phe Phe Val Thr Asn Ile Val Asp Pro Phe Ile Asp Tyr Thr 
        275                 280                 285             


Val Pro Gly Gln Val Trp Thr Ala Phe Leu Trp Leu Gly Tyr Ile Asn 
    290                 295                 300                 


Ser Gly Leu Asn Pro Phe Leu Tyr Ala Phe Leu Asn Lys Ser Phe Arg 
305                 310                 315                 320 


Arg Ala Phe Leu Ile Ile Leu Cys Cys Asp Asp Glu Arg Tyr Arg Arg 
                325                 330                 335     


Pro Ser Ile Leu Gly Gln Thr Val Pro Cys Ser Thr Thr Thr Ile Asn 
            340                 345                 350         


Gly Ser Thr His Val Leu Arg Asp Ala Val Glu Cys Gly Gly Gln Trp 
        355                 360                 365             


Glu Ser Gln Cys His Pro Pro Ala Thr Ser Pro Leu Val Ala Ala Gln 
    370                 375                 380                 


Pro Ser Asp Thr 
385             


<210>  5249
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR5A__Homo_sapiens__NP_076917

<400>  5249

Met Asp Leu Pro Val Asn Leu Thr Ser Phe Ser Leu Ser Thr Pro Ser 
1               5                   10                  15      


Pro Leu Glu Thr Asn His Ser Leu Gly Lys Asp Asp Leu Arg Pro Ser 
            20                  25                  30          


Ser Pro Leu Leu Ser Val Phe Gly Val Leu Ile Leu Thr Leu Leu Gly 
        35                  40                  45              


Phe Leu Val Ala Ala Thr Phe Ala Trp Asn Leu Leu Val Leu Ala Thr 
    50                  55                  60                  


Ile Leu Arg Val Arg Thr Phe His Arg Val Pro His Asn Leu Val Ala 
65                  70                  75                  80  


Ser Met Ala Val Ser Asp Val Leu Val Ala Ala Leu Val Met Pro Leu 
                85                  90                  95      


Ser Leu Val His Glu Leu Ser Gly Arg Arg Trp Gln Leu Gly Arg Arg 
            100                 105                 110         


Leu Cys Gln Leu Trp Ile Ala Cys Asp Val Leu Cys Cys Thr Ala Ser 
        115                 120                 125             


Ile Trp Asn Val Thr Ala Ile Ala Leu Asp Arg Tyr Trp Ser Ile Thr 
    130                 135                 140                 


Arg His Met Glu Tyr Thr Leu Arg Thr Arg Lys Cys Val Ser Asn Val 
145                 150                 155                 160 


Met Ile Ala Leu Thr Trp Ala Leu Ser Ala Val Ile Ser Leu Ala Pro 
                165                 170                 175     


Leu Leu Phe Gly Trp Gly Glu Thr Tyr Ser Glu Gly Ser Glu Glu Cys 
            180                 185                 190         


Gln Val Ser Arg Glu Pro Ser Tyr Ala Val Phe Ser Thr Val Gly Ala 
        195                 200                 205             


Phe Tyr Leu Pro Leu Cys Val Val Leu Phe Val Tyr Trp Lys Ile Tyr 
    210                 215                 220                 


Lys Ala Ala Lys Phe Arg Val Gly Ser Arg Lys Thr Asn Ser Val Ser 
225                 230                 235                 240 


Pro Ile Ser Glu Ala Val Glu Val Lys Asp Ser Ala Lys Gln Pro Gln 
                245                 250                 255     


Met Val Phe Thr Val Arg His Ala Thr Val Thr Phe Gln Pro Glu Gly 
            260                 265                 270         


Asp Thr Trp Arg Glu Gln Lys Glu Gln Arg Ala Ala Leu Met Val Gly 
        275                 280                 285             


Ile Leu Ile Gly Val Phe Val Leu Cys Trp Ile Pro Phe Phe Leu Thr 
    290                 295                 300                 


Glu Leu Ile Ser Pro Leu Cys Ser Cys Asp Ile Pro Ala Ile Trp Lys 
305                 310                 315                 320 


Ser Ile Phe Leu Trp Leu Gly Tyr Ser Asn Ser Phe Phe Asn Pro Leu 
                325                 330                 335     


Ile Tyr Thr Ala Phe Asn Lys Asn Tyr Asn Ser Ala Phe Lys Asn Phe 
            340                 345                 350         


Phe Ser Arg Gln His 
        355         


<210>  5250
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTR7__Homo_sapiens__NP_000863

<400>  5250

Met Met Asp Val Asn Ser Ser Gly Arg Pro Asp Leu Tyr Gly His Leu 
1               5                   10                  15      


Arg Ser Phe Leu Leu Pro Glu Val Gly Arg Gly Leu Pro Asp Leu Ser 
            20                  25                  30          


Pro Asp Gly Gly Ala Asp Pro Val Ala Gly Ser Trp Ala Pro His Leu 
        35                  40                  45              


Leu Ser Glu Val Thr Ala Ser Pro Ala Pro Thr Trp Asp Ala Pro Pro 
    50                  55                  60                  


Asp Asn Ala Ser Gly Cys Gly Glu Gln Ile Asn Tyr Gly Arg Val Glu 
65                  70                  75                  80  


Lys Val Val Ile Gly Ser Ile Leu Thr Leu Ile Thr Leu Leu Thr Ile 
                85                  90                  95      


Ala Gly Asn Cys Leu Val Val Ile Ser Val Cys Phe Val Lys Lys Leu 
            100                 105                 110         


Arg Gln Pro Ser Asn Tyr Leu Ile Val Ser Leu Ala Leu Ala Asp Leu 
        115                 120                 125             


Ser Val Ala Val Ala Val Met Pro Phe Val Ser Val Thr Asp Leu Ile 
    130                 135                 140                 


Gly Gly Lys Trp Ile Phe Gly His Phe Phe Cys Asn Val Phe Ile Ala 
145                 150                 155                 160 


Met Asp Val Met Cys Cys Thr Ala Ser Ile Met Thr Leu Cys Val Ile 
                165                 170                 175     


Ser Ile Asp Arg Tyr Leu Gly Ile Thr Arg Pro Leu Thr Tyr Pro Val 
            180                 185                 190         


Arg Gln Asn Gly Lys Cys Met Ala Lys Met Ile Leu Ser Val Trp Leu 
        195                 200                 205             


Leu Ser Ala Ser Ile Thr Leu Pro Pro Leu Phe Gly Trp Ala Gln Asn 
    210                 215                 220                 


Val Asn Asp Asp Lys Val Cys Leu Ile Ser Gln Asp Phe Gly Tyr Thr 
225                 230                 235                 240 


Ile Tyr Ser Thr Ala Val Ala Phe Tyr Ile Pro Met Ser Val Met Leu 
                245                 250                 255     


Phe Met Tyr Tyr Gln Ile Tyr Lys Ala Ala Arg Lys Ser Ala Ala Lys 
            260                 265                 270         


His Lys Phe Pro Gly Phe Pro Arg Val Glu Pro Asp Ser Val Ile Ala 
        275                 280                 285             


Leu Asn Gly Ile Val Lys Leu Gln Lys Glu Val Glu Glu Cys Ala Asn 
    290                 295                 300                 


Leu Ser Arg Leu Leu Lys His Glu Arg Lys Asn Ile Ser Ile Phe Lys 
305                 310                 315                 320 


Arg Glu Gln Lys Ala Ala Thr Thr Leu Gly Ile Ile Val Gly Ala Phe 
                325                 330                 335     


Thr Val Cys Trp Leu Pro Phe Phe Leu Leu Ser Thr Ala Arg Pro Phe 
            340                 345                 350         


Ile Cys Gly Thr Ser Cys Ser Cys Ile Pro Leu Trp Val Glu Arg Thr 
        355                 360                 365             


Phe Leu Trp Leu Gly Tyr Ala Asn Ser Leu Ile Asn Pro Phe Ile Tyr 
    370                 375                 380                 


Ala Phe Phe Asn Arg Asp Leu Arg Thr Thr Tyr Arg Ser Leu Leu Gln 
385                 390                 395                 400 


Cys Gln Tyr Arg Asn Ile Asn Arg Lys Leu Ser Ala Ala Gly Met His 
                405                 410                 415     


Glu Ala Leu Lys Leu Ala Glu Arg Pro Glu Arg Pro Glu Phe Val Leu 
            420                 425                 430         


Gln Asn Ala Asp Tyr Cys Arg Lys Lys Gly His Asp Ser 
        435                 440                 445 


<210>  5251
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTRA1__Homo_sapiens__NP_002766

<400>  5251

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Gln Leu Ser Arg Ala Gly Arg Ser Ala Pro 
            20                  25                  30          


Leu Ala Ala Gly Cys Pro Asp Arg Cys Glu Pro Ala Arg Cys Pro Pro 
        35                  40                  45              


Gln Pro Glu His Cys Glu Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys 
    50                  55                  60                  


Cys Glu Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu 
65                  70                  75                  80  


Gly Pro Cys Gly Glu Gly Leu Gln Cys Val Val Pro Phe Gly Val Pro 
                85                  90                  95      


Ala Ser Ala Thr Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys 
            100                 105                 110         


Ala Ser Ser Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn 
        115                 120                 125             


Leu Cys Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg 
    130                 135                 140                 


Pro Pro Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu 
145                 150                 155                 160 


Asp Pro Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val 
                165                 170                 175     


Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu 
            180                 185                 190         


Pro Phe Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile 
        195                 200                 205             


Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn 
    210                 215                 220                 


Lys His Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala 
225                 230                 235                 240 


Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile 
                245                 250                 255     


Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu 
            260                 265                 270         


Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu 
        275                 280                 285             


Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly 
    290                 295                 300                 


Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp 
305                 310                 315                 320 


Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp 
                325                 330                 335     


Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser 
            340                 345                 350         


Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His 
        355                 360                 365             


Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly 
    370                 375                 380                 


Ile Arg Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp 
385                 390                 395                 400 


Arg His Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu 
                405                 410                 415     


Val Ile Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp 
            420                 425                 430         


Val Ile Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val 
        435                 440                 445             


Ser Asp Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg 
    450                 455                 460                 


Gly Asn Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
465                 470                 475                 480 


<210>  5252
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTRA2__Homo_sapiens__NP_037379

<400>  5252

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr 
            20                  25                  30          


Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
        35                  40                  45              


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly 
    50                  55                  60                  


Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg 
65                  70                  75                  80  


Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser 
                85                  90                  95      


Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly 
            100                 105                 110         


Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro 
        115                 120                 125             


Pro Ala Val Leu Ala Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg 
    130                 135                 140                 


Ser Gln Tyr Asn Phe Ile Ala Asp Val Val Glu Lys Thr Ala Pro Ala 
145                 150                 155                 160 


Val Val Tyr Ile Glu Ile Leu Asp Arg His Pro Phe Leu Gly Arg Glu 
                165                 170                 175     


Val Pro Ile Ser Asn Gly Ser Gly Phe Val Val Ala Ala Asp Gly Leu 
            180                 185                 190         


Ile Val Thr Asn Ala His Val Val Ala Asp Arg Arg Arg Val Arg Val 
        195                 200                 205             


Arg Leu Leu Ser Gly Asp Thr Tyr Glu Ala Val Val Thr Ala Val Asp 
    210                 215                 220                 


Pro Val Ala Asp Ile Ala Thr Leu Arg Ile Gln Thr Lys Glu Pro Leu 
225                 230                 235                 240 


Pro Thr Leu Pro Leu Gly Arg Ser Ala Asp Val Arg Gln Gly Glu Phe 
                245                 250                 255     


Val Val Ala Met Gly Ser Pro Phe Ala Leu Gln Asn Thr Ile Thr Ser 
            260                 265                 270         


Gly Ile Val Ser Ser Ala Gln Arg Pro Ala Arg Asp Leu Gly Leu Pro 
        275                 280                 285             


Gln Thr Asn Val Glu Tyr Ile Gln Thr Asp Ala Ala Ile Asp Phe Gly 
    290                 295                 300                 


Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Val 
305                 310                 315                 320 


Asn Thr Met Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp 
                325                 330                 335     


Arg Leu Arg Glu Phe Leu His Arg Gly Glu Lys Lys Asn Ser Ser Ser 
            340                 345                 350         


Gly Ile Ser Gly Ser Gln Arg Arg Tyr Ile Gly Val Met Met Leu Thr 
        355                 360                 365             


Leu Ser Pro Ser Ile Leu Ala Glu Leu Gln Leu Arg Glu Pro Ser Phe 
    370                 375                 380                 


Pro Asp Val Gln His Gly Val Leu Ile His Lys Val Ile Leu Gly Ser 
385                 390                 395                 400 


Pro Ala His Arg Ala Gly Leu Arg Pro Gly Asp Val Ile Leu Ala Ile 
                405                 410                 415     


Gly Glu Gln Met Val Gln Asn Ala Glu Asp Val Tyr Glu Ala Val Arg 
            420                 425                 430         


Thr Gln Ser Gln Leu Ala Val Gln Ile Arg Arg Gly Arg Glu Thr Leu 
        435                 440                 445             


Thr Leu Tyr Val Thr Pro Glu Val Thr Glu 
    450                 455             


<210>  5253
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTRA3__Homo_sapiens__NP_001284488

<400>  5253

Met Gln Ala Arg Ala Leu Leu Leu Ala Ala Leu Ala Ala Leu Ala Leu 
1               5                   10                  15      


Ala Arg Glu Pro Pro Ala Ala Pro Cys Pro Ala Arg Cys Asp Val Ser 
            20                  25                  30          


Arg Cys Pro Ser Pro Arg Cys Pro Gly Gly Tyr Val Pro Asp Leu Cys 
        35                  40                  45              


Asn Cys Cys Leu Val Cys Ala Ala Ser Glu Gly Glu Pro Cys Gly Gly 
    50                  55                  60                  


Pro Leu Asp Ser Pro Cys Gly Glu Ser Leu Glu Cys Val Arg Gly Leu 
65                  70                  75                  80  


Cys Arg Cys Arg Trp Ser His Ala Val Cys Gly Thr Asp Gly His Thr 
                85                  90                  95      


Tyr Ala Asn Val Cys Ala Leu Gln Ala Ala Ser Arg Arg Ala Leu Gln 
            100                 105                 110         


Leu Ser Gly Thr Pro Val Arg Gln Leu Gln Lys Gly Ala Cys Pro Leu 
        115                 120                 125             


Gly Leu His Gln Leu Ser Ser Pro Arg Tyr Lys Phe Asn Phe Ile Ala 
    130                 135                 140                 


Asp Val Val Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe 
145                 150                 155                 160 


Leu Arg His Pro Leu Phe Gly Arg Asn Val Pro Leu Ser Ser Gly Ser 
                165                 170                 175     


Gly Phe Ile Met Ser Glu Ala Gly Leu Ile Ile Thr Asn Ala His Val 
            180                 185                 190         


Val Ser Ser Asn Ser Ala Ala Pro Gly Arg Gln Gln Leu Lys Val Gln 
        195                 200                 205             


Leu Gln Asn Gly Asp Ser Tyr Glu Ala Thr Ile Lys Asp Ile Asp Lys 
    210                 215                 220                 


Lys Ser Asp Ile Ala Thr Ile Lys Ile His Pro Lys Lys Lys Leu Pro 
225                 230                 235                 240 


Val Leu Leu Leu Gly His Ser Ala Asp Leu Arg Pro Gly Glu Phe Val 
                245                 250                 255     


Val Ala Ile Gly Ser Pro Phe Ala Leu Gln Asn Thr Val Thr Thr Gly 
            260                 265                 270         


Ile Val Ser Thr Ala Gln Arg Glu Gly Arg Glu Leu Gly Leu Arg Asp 
        275                 280                 285             


Ser Asp Met Asp Tyr Ile Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn 
    290                 295                 300                 


Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Glu Val Ile Gly Ile Asn 
305                 310                 315                 320 


Thr Leu Lys Val Thr Ala Gly Ile Ser Phe Ala Ile Pro Ser Asp Arg 
                325                 330                 335     


Ile Thr Arg Phe Leu Thr Glu Phe Gln Asp Lys Gln Ile Lys Ala Pro 
            340                 345                 350         


Ser Leu Ala Val His 
        355         


<210>  5254
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTRA4__Homo_sapiens__NP_710159

<400>  5254

Met Ile Arg Pro Gln Leu Arg Thr Ala Gly Leu Gly Arg Cys Leu Leu 
1               5                   10                  15      


Pro Gly Leu Leu Leu Leu Leu Val Pro Val Leu Trp Ala Gly Ala Glu 
            20                  25                  30          


Lys Leu His Thr Gln Pro Ser Cys Pro Ala Val Cys Gln Pro Thr Arg 
        35                  40                  45              


Cys Pro Ala Leu Pro Thr Cys Ala Leu Gly Thr Thr Pro Val Phe Asp 
    50                  55                  60                  


Leu Cys Arg Cys Cys Arg Val Cys Pro Ala Ala Glu Arg Glu Val Cys 
65                  70                  75                  80  


Gly Gly Ala Gln Gly Gln Pro Cys Ala Pro Gly Leu Gln Cys Leu Gln 
                85                  90                  95      


Pro Leu Arg Pro Gly Phe Pro Ser Thr Cys Gly Cys Pro Thr Leu Gly 
            100                 105                 110         


Gly Ala Val Cys Gly Ser Asp Arg Arg Thr Tyr Pro Ser Met Cys Ala 
        115                 120                 125             


Leu Arg Ala Glu Asn Arg Ala Ala Arg Arg Leu Gly Lys Val Pro Ala 
    130                 135                 140                 


Val Pro Val Gln Trp Gly Asn Cys Gly Asp Thr Gly Thr Arg Ser Ala 
145                 150                 155                 160 


Gly Pro Leu Arg Arg Asn Tyr Asn Phe Ile Ala Ala Val Val Glu Lys 
                165                 170                 175     


Val Ala Pro Ser Val Val His Val Gln Leu Trp Gly Arg Leu Leu His 
            180                 185                 190         


Gly Ser Arg Leu Val Pro Val Tyr Ser Gly Ser Gly Phe Ile Val Ser 
        195                 200                 205             


Glu Asp Gly Leu Ile Ile Thr Asn Ala His Val Val Arg Asn Gln Gln 
    210                 215                 220                 


Trp Ile Glu Val Val Leu Gln Asn Gly Ala Arg Tyr Glu Ala Val Val 
225                 230                 235                 240 


Lys Asp Ile Asp Leu Lys Leu Asp Leu Ala Val Ile Lys Ile Glu Ser 
                245                 250                 255     


Asn Ala Glu Leu Pro Val Leu Met Leu Gly Arg Ser Ser Asp Leu Arg 
            260                 265                 270         


Ala Gly Glu Phe Val Val Ala Leu Gly Ser Pro Phe Ser Leu Gln Asn 
        275                 280                 285             


Thr Ala Thr Ala Gly Ile Val Ser Thr Lys Gln Arg Gly Gly Lys Glu 
    290                 295                 300                 


Leu Gly Met Lys Asp Ser Asp Met Asp Tyr Val Gln Ile Asp Ala Thr 
305                 310                 315                 320 


Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp Gly Asp 
                325                 330                 335     


Val Ile Gly Val Asn Ser Leu Arg Val Thr Asp Gly Ile Ser Phe Ala 
            340                 345                 350         


Ile Pro Ser Asp Arg Val Arg Gln Phe Leu Ala Glu Tyr His Glu His 
        355                 360                 365             


Gln Met Lys Gly Lys Ala Phe Ser Asn Lys Lys Tyr Leu Gly Leu Gln 
    370                 375                 380                 


Met Leu Ser Leu Thr Val Pro Leu Ser Glu Glu Leu Lys Met His Tyr 
385                 390                 395                 400 


Pro Asp Phe Pro Asp Val Ser Ser Gly Val Tyr Val Cys Lys Val Val 
                405                 410                 415     


Glu Gly Thr Ala Ala Gln Ser Ser Gly Leu Arg Asp His Asp Val Ile 
            420                 425                 430         


Val Asn Ile Asn Gly Lys Pro Ile Thr Thr Thr Thr Asp Val Val Lys 
        435                 440                 445             


Ala Leu Asp Ser Asp Ser Leu Ser Met Ala Val Leu Arg Gly Lys Asp 
    450                 455                 460                 


Asn Leu Leu Leu Thr Val Ile Pro Glu Thr Ile Asn 
465                 470                 475     


<210>  5255
<211>  3144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTT__Homo_sapiens__NP_002102

<400>  5255

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
    50                  55                  60                  


Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro 
65                  70                  75                  80  


Ala Val Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala 
                85                  90                  95      


Thr Lys Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile 
            100                 105                 110         


Val Ala Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly 
        115                 120                 125             


Ile Ala Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp 
    130                 135                 140                 


Val Arg Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu 
145                 150                 155                 160 


Met Asp Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile 
                165                 170                 175     


Lys Lys Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe 
            180                 185                 190         


Ala Glu Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu 
        195                 200                 205             


Val Asn Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu 
    210                 215                 220                 


Ser Val Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser 
225                 230                 235                 240 


Phe Gly Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala 
                245                 250                 255     


Phe Ile Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala 
            260                 265                 270         


Ala Gly Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr 
        275                 280                 285             


Phe Tyr Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val 
    290                 295                 300                 


Glu Asp Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu 
305                 310                 315                 320 


Arg Tyr Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu 
                325                 330                 335     


Lys Gly Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser 
            340                 345                 350         


Ala Glu Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln 
        355                 360                 365             


His Gln Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln 
    370                 375                 380                 


Leu Phe Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val 
385                 390                 395                 400 


Gly Gly Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg 
                405                 410                 415     


Ser Arg Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser 
            420                 425                 430         


Cys Ser Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly 
        435                 440                 445             


Glu Glu Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser 
    450                 455                 460                 


Ser Ser Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu 
465                 470                 475                 480 


Ala Ala Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile 
                485                 490                 495     


Ile Thr Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val 
            500                 505                 510         


Asp Leu Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu 
        515                 520                 525             


Glu Asp Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser 
    530                 535                 540                 


Asp Pro Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile 
545                 550                 555                 560 


Ser Asp Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr 
                565                 570                 575     


Pro Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr 
            580                 585                 590         


Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr 
        595                 600                 605             


Gly Ile Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met 
    610                 615                 620                 


Ala Leu Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln 
625                 630                 635                 640 


Pro Ser Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr 
                645                 650                 655     


Glu Pro Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile 
            660                 665                 670         


Gly Gln Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg 
        675                 680                 685             


Leu Leu Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val 
    690                 695                 700                 


Pro Asp Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys 
705                 710                 715                 720 


Val Gly Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu 
                725                 730                 735     


Tyr Lys Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val 
            740                 745                 750         


Ser Asp Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly 
        755                 760                 765             


Ala Thr Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg 
    770                 775                 780                 


Ser Arg Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr 
785                 790                 795                 800 


Gly Asn Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr 
                805                 810                 815     


Leu Lys Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val 
            820                 825                 830         


Arg Asn Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly 
        835                 840                 845             


Leu Gln Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp 
    850                 855                 860                 


Leu Val Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg 
865                 870                 875                 880 


Leu Val Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala 
                885                 890                 895     


His His Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn 
            900                 905                 910         


Val Val Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val 
        915                 920                 925             


Ala Ala Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys 
    930                 935                 940                 


Asp Gln Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser 
945                 950                 955                 960 


Ser Val Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His 
                965                 970                 975     


Phe Ser Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu 
            980                 985                 990         


Pro Ser Ile Thr Asp Val Thr Met  Glu Asn Asn Leu Ser  Arg Val Ile 
        995                 1000                 1005             


Ala Ala  Val Ser His Glu Leu  Ile Thr Ser Thr Thr  Arg Ala Leu 
    1010                 1015                 1020             


Thr Phe  Gly Cys Cys Glu Ala  Leu Cys Leu Leu Ser  Thr Ala Phe 
    1025                 1030                 1035             


Pro Val  Cys Ile Trp Ser Leu  Gly Trp His Cys Gly  Val Pro Pro 
    1040                 1045                 1050             


Leu Ser  Ala Ser Asp Glu Ser  Arg Lys Ser Cys Thr  Val Gly Met 
    1055                 1060                 1065             


Ala Thr  Met Ile Leu Thr Leu  Leu Ser Ser Ala Trp  Phe Pro Leu 
    1070                 1075                 1080             


Asp Leu  Ser Ala His Gln Asp  Ala Leu Ile Leu Ala  Gly Asn Leu 
    1085                 1090                 1095             


Leu Ala  Ala Ser Ala Pro Lys  Ser Leu Arg Ser Ser  Trp Ala Ser 
    1100                 1105                 1110             


Glu Glu  Glu Ala Asn Pro Ala  Ala Thr Lys Gln Glu  Glu Val Trp 
    1115                 1120                 1125             


Pro Ala  Leu Gly Asp Arg Ala  Leu Val Pro Met Val  Glu Gln Leu 
    1130                 1135                 1140             


Phe Ser  His Leu Leu Lys Val  Ile Asn Ile Cys Ala  His Val Leu 
    1145                 1150                 1155             


Asp Asp  Val Ala Pro Gly Pro  Ala Ile Lys Ala Ala  Leu Pro Ser 
    1160                 1165                 1170             


Leu Thr  Asn Pro Pro Ser Leu  Ser Pro Ile Arg Arg  Lys Gly Lys 
    1175                 1180                 1185             


Glu Lys  Glu Pro Gly Glu Gln  Ala Ser Val Pro Leu  Ser Pro Lys 
    1190                 1195                 1200             


Lys Gly  Ser Glu Ala Ser Ala  Ala Ser Arg Gln Ser  Asp Thr Ser 
    1205                 1210                 1215             


Gly Pro  Val Thr Thr Ser Lys  Ser Ser Ser Leu Gly  Ser Phe Tyr 
    1220                 1225                 1230             


His Leu  Pro Ser Tyr Leu Lys  Leu His Asp Val Leu  Lys Ala Thr 
    1235                 1240                 1245             


His Ala  Asn Tyr Lys Val Thr  Leu Asp Leu Gln Asn  Ser Thr Glu 
    1250                 1255                 1260             


Lys Phe  Gly Gly Phe Leu Arg  Ser Ala Leu Asp Val  Leu Ser Gln 
    1265                 1270                 1275             


Ile Leu  Glu Leu Ala Thr Leu  Gln Asp Ile Gly Lys  Cys Val Glu 
    1280                 1285                 1290             


Glu Ile  Leu Gly Tyr Leu Lys  Ser Cys Phe Ser Arg  Glu Pro Met 
    1295                 1300                 1305             


Met Ala  Thr Val Cys Val Gln  Gln Leu Leu Lys Thr  Leu Phe Gly 
    1310                 1315                 1320             


Thr Asn  Leu Ala Ser Gln Phe  Asp Gly Leu Ser Ser  Asn Pro Ser 
    1325                 1330                 1335             


Lys Ser  Gln Gly Arg Ala Gln  Arg Leu Gly Ser Ser  Ser Val Arg 
    1340                 1345                 1350             


Pro Gly  Leu Tyr His Tyr Cys  Phe Met Ala Pro Tyr  Thr His Phe 
    1355                 1360                 1365             


Thr Gln  Ala Leu Ala Asp Ala  Ser Leu Arg Asn Met  Val Gln Ala 
    1370                 1375                 1380             


Glu Gln  Glu Asn Asp Thr Ser  Gly Trp Phe Asp Val  Leu Gln Lys 
    1385                 1390                 1395             


Val Ser  Thr Gln Leu Lys Thr  Asn Leu Thr Ser Val  Thr Lys Asn 
    1400                 1405                 1410             


Arg Ala  Asp Lys Asn Ala Ile  His Asn His Ile Arg  Leu Phe Glu 
    1415                 1420                 1425             


Pro Leu  Val Ile Lys Ala Leu  Lys Gln Tyr Thr Thr  Thr Thr Cys 
    1430                 1435                 1440             


Val Gln  Leu Gln Lys Gln Val  Leu Asp Leu Leu Ala  Gln Leu Val 
    1445                 1450                 1455             


Gln Leu  Arg Val Asn Tyr Cys  Leu Leu Asp Ser Asp  Gln Val Phe 
    1460                 1465                 1470             


Ile Gly  Phe Val Leu Lys Gln  Phe Glu Tyr Ile Glu  Val Gly Gln 
    1475                 1480                 1485             


Phe Arg  Glu Ser Glu Ala Ile  Ile Pro Asn Ile Phe  Phe Phe Leu 
    1490                 1495                 1500             


Val Leu  Leu Ser Tyr Glu Arg  Tyr His Ser Lys Gln  Ile Ile Gly 
    1505                 1510                 1515             


Ile Pro  Lys Ile Ile Gln Leu  Cys Asp Gly Ile Met  Ala Ser Gly 
    1520                 1525                 1530             


Arg Lys  Ala Val Thr His Ala  Ile Pro Ala Leu Gln  Pro Ile Val 
    1535                 1540                 1545             


His Asp  Leu Phe Val Leu Arg  Gly Thr Asn Lys Ala  Asp Ala Gly 
    1550                 1555                 1560             


Lys Glu  Leu Glu Thr Gln Lys  Glu Val Val Val Ser  Met Leu Leu 
    1565                 1570                 1575             


Arg Leu  Ile Gln Tyr His Gln  Val Leu Glu Met Phe  Ile Leu Val 
    1580                 1585                 1590             


Leu Gln  Gln Cys His Lys Glu  Asn Glu Asp Lys Trp  Lys Arg Leu 
    1595                 1600                 1605             


Ser Arg  Gln Ile Ala Asp Ile  Ile Leu Pro Met Leu  Ala Lys Gln 
    1610                 1615                 1620             


Gln Met  His Ile Asp Ser His  Glu Ala Leu Gly Val  Leu Asn Thr 
    1625                 1630                 1635             


Leu Phe  Glu Ile Leu Ala Pro  Ser Ser Leu Arg Pro  Val Asp Met 
    1640                 1645                 1650             


Leu Leu  Arg Ser Met Phe Val  Thr Pro Asn Thr Met  Ala Ser Val 
    1655                 1660                 1665             


Ser Thr  Val Gln Leu Trp Ile  Ser Gly Ile Leu Ala  Ile Leu Arg 
    1670                 1675                 1680             


Val Leu  Ile Ser Gln Ser Thr  Glu Asp Ile Val Leu  Ser Arg Ile 
    1685                 1690                 1695             


Gln Glu  Leu Ser Phe Ser Pro  Tyr Leu Ile Ser Cys  Thr Val Ile 
    1700                 1705                 1710             


Asn Arg  Leu Arg Asp Gly Asp  Ser Thr Ser Thr Leu  Glu Glu His 
    1715                 1720                 1725             


Ser Glu  Gly Lys Gln Ile Lys  Asn Leu Pro Glu Glu  Thr Phe Ser 
    1730                 1735                 1740             


Arg Phe  Leu Leu Gln Leu Val  Gly Ile Leu Leu Glu  Asp Ile Val 
    1745                 1750                 1755             


Thr Lys  Gln Leu Lys Val Glu  Met Ser Glu Gln Gln  His Thr Phe 
    1760                 1765                 1770             


Tyr Cys  Gln Glu Leu Gly Thr  Leu Leu Met Cys Leu  Ile His Ile 
    1775                 1780                 1785             


Phe Lys  Ser Gly Met Phe Arg  Arg Ile Thr Ala Ala  Ala Thr Arg 
    1790                 1795                 1800             


Leu Phe  Arg Ser Asp Gly Cys  Gly Gly Ser Phe Tyr  Thr Leu Asp 
    1805                 1810                 1815             


Ser Leu  Asn Leu Arg Ala Arg  Ser Met Ile Thr Thr  His Pro Ala 
    1820                 1825                 1830             


Leu Val  Leu Leu Trp Cys Gln  Ile Leu Leu Leu Val  Asn His Thr 
    1835                 1840                 1845             


Asp Tyr  Arg Trp Trp Ala Glu  Val Gln Gln Thr Pro  Lys Arg His 
    1850                 1855                 1860             


Ser Leu  Ser Ser Thr Lys Leu  Leu Ser Pro Gln Met  Ser Gly Glu 
    1865                 1870                 1875             


Glu Glu  Asp Ser Asp Leu Ala  Ala Lys Leu Gly Met  Cys Asn Arg 
    1880                 1885                 1890             


Glu Ile  Val Arg Arg Gly Ala  Leu Ile Leu Phe Cys  Asp Tyr Val 
    1895                 1900                 1905             


Cys Gln  Asn Leu His Asp Ser  Glu His Leu Thr Trp  Leu Ile Val 
    1910                 1915                 1920             


Asn His  Ile Gln Asp Leu Ile  Ser Leu Ser His Glu  Pro Pro Val 
    1925                 1930                 1935             


Gln Asp  Phe Ile Ser Ala Val  His Arg Asn Ser Ala  Ala Ser Gly 
    1940                 1945                 1950             


Leu Phe  Ile Gln Ala Ile Gln  Ser Arg Cys Glu Asn  Leu Ser Thr 
    1955                 1960                 1965             


Pro Thr  Met Leu Lys Lys Thr  Leu Gln Cys Leu Glu  Gly Ile His 
    1970                 1975                 1980             


Leu Ser  Gln Ser Gly Ala Val  Leu Thr Leu Tyr Val  Asp Arg Leu 
    1985                 1990                 1995             


Leu Cys  Thr Pro Phe Arg Val  Leu Ala Arg Met Val  Asp Ile Leu 
    2000                 2005                 2010             


Ala Cys  Arg Arg Val Glu Met  Leu Leu Ala Ala Asn  Leu Gln Ser 
    2015                 2020                 2025             


Ser Met  Ala Gln Leu Pro Met  Glu Glu Leu Asn Arg  Ile Gln Glu 
    2030                 2035                 2040             


Tyr Leu  Gln Ser Ser Gly Leu  Ala Gln Arg His Gln  Arg Leu Tyr 
    2045                 2050                 2055             


Ser Leu  Leu Asp Arg Phe Arg  Leu Ser Thr Met Gln  Asp Ser Leu 
    2060                 2065                 2070             


Ser Pro  Ser Pro Pro Val Ser  Ser His Pro Leu Asp  Gly Asp Gly 
    2075                 2080                 2085             


His Val  Ser Leu Glu Thr Val  Ser Pro Asp Lys Asp  Trp Tyr Val 
    2090                 2095                 2100             


His Leu  Val Lys Ser Gln Cys  Trp Thr Arg Ser Asp  Ser Ala Leu 
    2105                 2110                 2115             


Leu Glu  Gly Ala Glu Leu Val  Asn Arg Ile Pro Ala  Glu Asp Met 
    2120                 2125                 2130             


Asn Ala  Phe Met Met Asn Ser  Glu Phe Asn Leu Ser  Leu Leu Ala 
    2135                 2140                 2145             


Pro Cys  Leu Ser Leu Gly Met  Ser Glu Ile Ser Gly  Gly Gln Lys 
    2150                 2155                 2160             


Ser Ala  Leu Phe Glu Ala Ala  Arg Glu Val Thr Leu  Ala Arg Val 
    2165                 2170                 2175             


Ser Gly  Thr Val Gln Gln Leu  Pro Ala Val His His  Val Phe Gln 
    2180                 2185                 2190             


Pro Glu  Leu Pro Ala Glu Pro  Ala Ala Tyr Trp Ser  Lys Leu Asn 
    2195                 2200                 2205             


Asp Leu  Phe Gly Asp Ala Ala  Leu Tyr Gln Ser Leu  Pro Thr Leu 
    2210                 2215                 2220             


Ala Arg  Ala Leu Ala Gln Tyr  Leu Val Val Val Ser  Lys Leu Pro 
    2225                 2230                 2235             


Ser His  Leu His Leu Pro Pro  Glu Lys Glu Lys Asp  Ile Val Lys 
    2240                 2245                 2250             


Phe Val  Val Ala Thr Leu Glu  Ala Leu Ser Trp His  Leu Ile His 
    2255                 2260                 2265             


Glu Gln  Ile Pro Leu Ser Leu  Asp Leu Gln Ala Gly  Leu Asp Cys 
    2270                 2275                 2280             


Cys Cys  Leu Ala Leu Gln Leu  Pro Gly Leu Trp Ser  Val Val Ser 
    2285                 2290                 2295             


Ser Thr  Glu Phe Val Thr His  Ala Cys Ser Leu Ile  Tyr Cys Val 
    2300                 2305                 2310             


His Phe  Ile Leu Glu Ala Val  Ala Val Gln Pro Gly  Glu Gln Leu 
    2315                 2320                 2325             


Leu Ser  Pro Glu Arg Arg Thr  Asn Thr Pro Lys Ala  Ile Ser Glu 
    2330                 2335                 2340             


Glu Glu  Glu Glu Val Asp Pro  Asn Thr Gln Asn Pro  Lys Tyr Ile 
    2345                 2350                 2355             


Thr Ala  Ala Cys Glu Met Val  Ala Glu Met Val Glu  Ser Leu Gln 
    2360                 2365                 2370             


Ser Val  Leu Ala Leu Gly His  Lys Arg Asn Ser Gly  Val Pro Ala 
    2375                 2380                 2385             


Phe Leu  Thr Pro Leu Leu Arg  Asn Ile Ile Ile Ser  Leu Ala Arg 
    2390                 2395                 2400             


Leu Pro  Leu Val Asn Ser Tyr  Thr Arg Val Pro Pro  Leu Val Trp 
    2405                 2410                 2415             


Lys Leu  Gly Trp Ser Pro Lys  Pro Gly Gly Asp Phe  Gly Thr Ala 
    2420                 2425                 2430             


Phe Pro  Glu Ile Pro Val Glu  Phe Leu Gln Glu Lys  Glu Val Phe 
    2435                 2440                 2445             


Lys Glu  Phe Ile Tyr Arg Ile  Asn Thr Leu Gly Trp  Thr Ser Arg 
    2450                 2455                 2460             


Thr Gln  Phe Glu Glu Thr Trp  Ala Thr Leu Leu Gly  Val Leu Val 
    2465                 2470                 2475             


Thr Gln  Pro Leu Val Met Glu  Gln Glu Glu Ser Pro  Pro Glu Glu 
    2480                 2485                 2490             


Asp Thr  Glu Arg Thr Gln Ile  Asn Val Leu Ala Val  Gln Ala Ile 
    2495                 2500                 2505             


Thr Ser  Leu Val Leu Ser Ala  Met Thr Val Pro Val  Ala Gly Asn 
    2510                 2515                 2520             


Pro Ala  Val Ser Cys Leu Glu  Gln Gln Pro Arg Asn  Lys Pro Leu 
    2525                 2530                 2535             


Lys Ala  Leu Asp Thr Arg Phe  Gly Arg Lys Leu Ser  Ile Ile Arg 
    2540                 2545                 2550             


Gly Ile  Val Glu Gln Glu Ile  Gln Ala Met Val Ser  Lys Arg Glu 
    2555                 2560                 2565             


Asn Ile  Ala Thr His His Leu  Tyr Gln Ala Trp Asp  Pro Val Pro 
    2570                 2575                 2580             


Ser Leu  Ser Pro Ala Thr Thr  Gly Ala Leu Ile Ser  His Glu Lys 
    2585                 2590                 2595             


Leu Leu  Leu Gln Ile Asn Pro  Glu Arg Glu Leu Gly  Ser Met Ser 
    2600                 2605                 2610             


Tyr Lys  Leu Gly Gln Val Ser  Ile His Ser Val Trp  Leu Gly Asn 
    2615                 2620                 2625             


Ser Ile  Thr Pro Leu Arg Glu  Glu Glu Trp Asp Glu  Glu Glu Glu 
    2630                 2635                 2640             


Glu Glu  Ala Asp Ala Pro Ala  Pro Ser Ser Pro Pro  Thr Ser Pro 
    2645                 2650                 2655             


Val Asn  Ser Arg Lys His Arg  Ala Gly Val Asp Ile  His Ser Cys 
    2660                 2665                 2670             


Ser Gln  Phe Leu Leu Glu Leu  Tyr Ser Arg Trp Ile  Leu Pro Ser 
    2675                 2680                 2685             


Ser Ser  Ala Arg Arg Thr Pro  Ala Ile Leu Ile Ser  Glu Val Val 
    2690                 2695                 2700             


Arg Ser  Leu Leu Val Val Ser  Asp Leu Phe Thr Glu  Arg Asn Gln 
    2705                 2710                 2715             


Phe Glu  Leu Met Tyr Val Thr  Leu Thr Glu Leu Arg  Arg Val His 
    2720                 2725                 2730             


Pro Ser  Glu Asp Glu Ile Leu  Ala Gln Tyr Leu Val  Pro Ala Thr 
    2735                 2740                 2745             


Cys Lys  Ala Ala Ala Val Leu  Gly Met Asp Lys Ala  Val Ala Glu 
    2750                 2755                 2760             


Pro Val  Ser Arg Leu Leu Glu  Ser Thr Leu Arg Ser  Ser His Leu 
    2765                 2770                 2775             


Pro Ser  Arg Val Gly Ala Leu  His Gly Val Leu Tyr  Val Leu Glu 
    2780                 2785                 2790             


Cys Asp  Leu Leu Asp Asp Thr  Ala Lys Gln Leu Ile  Pro Val Ile 
    2795                 2800                 2805             


Ser Asp  Tyr Leu Leu Ser Asn  Leu Lys Gly Ile Ala  His Cys Val 
    2810                 2815                 2820             


Asn Ile  His Ser Gln Gln His  Val Leu Val Met Cys  Ala Thr Ala 
    2825                 2830                 2835             


Phe Tyr  Leu Ile Glu Asn Tyr  Pro Leu Asp Val Gly  Pro Glu Phe 
    2840                 2845                 2850             


Ser Ala  Ser Ile Ile Gln Met  Cys Gly Val Met Leu  Ser Gly Ser 
    2855                 2860                 2865             


Glu Glu  Ser Thr Pro Ser Ile  Ile Tyr His Cys Ala  Leu Arg Gly 
    2870                 2875                 2880             


Leu Glu  Arg Leu Leu Leu Ser  Glu Gln Leu Ser Arg  Leu Asp Ala 
    2885                 2890                 2895             


Glu Ser  Leu Val Lys Leu Ser  Val Asp Arg Val Asn  Val His Ser 
    2900                 2905                 2910             


Pro His  Arg Ala Met Ala Ala  Leu Gly Leu Met Leu  Thr Cys Met 
    2915                 2920                 2925             


Tyr Thr  Gly Lys Glu Lys Val  Ser Pro Gly Arg Thr  Ser Asp Pro 
    2930                 2935                 2940             


Asn Pro  Ala Ala Pro Asp Ser  Glu Ser Val Ile Val  Ala Met Glu 
    2945                 2950                 2955             


Arg Val  Ser Val Leu Phe Asp  Arg Ile Arg Lys Gly  Phe Pro Cys 
    2960                 2965                 2970             


Glu Ala  Arg Val Val Ala Arg  Ile Leu Pro Gln Phe  Leu Asp Asp 
    2975                 2980                 2985             


Phe Phe  Pro Pro Gln Asp Ile  Met Asn Lys Val Ile  Gly Glu Phe 
    2990                 2995                 3000             


Leu Ser  Asn Gln Gln Pro Tyr  Pro Gln Phe Met Ala  Thr Val Val 
    3005                 3010                 3015             


Tyr Lys  Val Phe Gln Thr Leu  His Ser Thr Gly Gln  Ser Ser Met 
    3020                 3025                 3030             


Val Arg  Asp Trp Val Met Leu  Ser Leu Ser Asn Phe  Thr Gln Arg 
    3035                 3040                 3045             


Ala Pro  Val Ala Met Ala Thr  Trp Ser Leu Ser Cys  Phe Phe Val 
    3050                 3055                 3060             


Ser Ala  Ser Thr Ser Pro Trp  Val Ala Ala Ile Leu  Pro His Val 
    3065                 3070                 3075             


Ile Ser  Arg Met Gly Lys Leu  Glu Gln Val Asp Val  Asn Leu Phe 
    3080                 3085                 3090             


Cys Leu  Val Ala Thr Asp Phe  Tyr Arg His Gln Ile  Glu Glu Glu 
    3095                 3100                 3105             


Leu Asp  Arg Arg Ala Phe Gln  Ser Val Leu Glu Val  Val Ala Ala 
    3110                 3115                 3120             


Pro Gly  Ser Pro Tyr His Arg  Leu Leu Thr Cys Leu  Arg Asn Val 
    3125                 3130                 3135             


His Lys  Val Thr Thr Cys 
    3140                 


<210>  5256
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUNK__Homo_sapiens__NP_055401

<400>  5256

Met Pro Ala Ala Ala Gly Asp Gly Leu Leu Gly Glu Pro Ala Ala Pro 
1               5                   10                  15      


Gly Gly Gly Gly Gly Ala Glu Asp Ala Ala Arg Pro Ala Ala Ala Cys 
            20                  25                  30          


Glu Gly Ser Phe Leu Pro Ala Trp Val Ser Gly Val Pro Arg Glu Arg 
        35                  40                  45              


Leu Arg Asp Phe Gln His His Lys Arg Val Gly Asn Tyr Leu Ile Gly 
    50                  55                  60                  


Ser Arg Lys Leu Gly Glu Gly Ser Phe Ala Lys Val Arg Glu Gly Leu 
65                  70                  75                  80  


His Val Leu Thr Gly Glu Lys Val Ala Ile Lys Val Ile Asp Lys Lys 
                85                  90                  95      


Arg Ala Lys Lys Asp Thr Tyr Val Thr Lys Asn Leu Arg Arg Glu Gly 
            100                 105                 110         


Gln Ile Gln Gln Met Ile Arg His Pro Asn Ile Thr Gln Leu Leu Asp 
        115                 120                 125             


Ile Leu Glu Thr Glu Asn Ser Tyr Tyr Leu Val Met Glu Leu Cys Pro 
    130                 135                 140                 


Gly Gly Asn Leu Met His Lys Ile Tyr Glu Lys Lys Arg Leu Glu Glu 
145                 150                 155                 160 


Ser Glu Ala Arg Arg Tyr Ile Arg Gln Leu Ile Ser Ala Val Glu His 
                165                 170                 175     


Leu His Arg Ala Gly Val Val His Arg Asp Leu Lys Ile Glu Asn Leu 
            180                 185                 190         


Leu Leu Asp Glu Asp Asn Asn Ile Lys Leu Ile Asp Phe Gly Leu Ser 
        195                 200                 205             


Asn Cys Ala Gly Ile Leu Gly Tyr Ser Asp Pro Phe Ser Thr Gln Cys 
    210                 215                 220                 


Gly Ser Pro Ala Tyr Ala Ala Pro Glu Leu Leu Ala Arg Lys Lys Tyr 
225                 230                 235                 240 


Gly Pro Lys Ile Asp Val Trp Ser Ile Gly Val Asn Met Tyr Ala Met 
                245                 250                 255     


Leu Thr Gly Thr Leu Pro Phe Thr Val Glu Pro Phe Ser Leu Arg Ala 
            260                 265                 270         


Leu Tyr Gln Lys Met Val Asp Lys Glu Met Asn Pro Leu Pro Thr Gln 
        275                 280                 285             


Leu Ser Thr Gly Ala Ile Ser Phe Leu Arg Ser Leu Leu Glu Pro Asp 
    290                 295                 300                 


Pro Val Lys Arg Pro Asn Ile Gln Gln Ala Leu Ala Asn Arg Trp Leu 
305                 310                 315                 320 


Asn Glu Asn Tyr Thr Gly Lys Val Pro Cys Asn Val Thr Tyr Pro Asn 
                325                 330                 335     


Arg Ile Ser Leu Glu Asp Leu Ser Pro Ser Val Val Leu His Met Thr 
            340                 345                 350         


Glu Lys Leu Gly Tyr Lys Asn Ser Asp Val Ile Asn Thr Val Leu Ser 
        355                 360                 365             


Asn Arg Ala Cys His Ile Leu Ala Ile Tyr Phe Leu Leu Asn Lys Lys 
    370                 375                 380                 


Leu Glu Arg Tyr Leu Ser Gly Lys Ser Asp Ile Gln Asp Ser Leu Cys 
385                 390                 395                 400 


Tyr Lys Thr Arg Leu Tyr Gln Ile Glu Lys Tyr Arg Ala Pro Lys Glu 
                405                 410                 415     


Ser Tyr Glu Ala Ser Leu Asp Thr Trp Thr Arg Asp Leu Glu Phe His 
            420                 425                 430         


Ala Val Gln Asp Lys Lys Pro Lys Glu Gln Glu Lys Arg Gly Asp Phe 
        435                 440                 445             


Leu His Arg Pro Phe Ser Lys Lys Leu Asp Lys Asn Leu Pro Ser His 
    450                 455                 460                 


Lys Gln Pro Ser Gly Ser Leu Met Thr Gln Ile Gln Asn Thr Lys Ala 
465                 470                 475                 480 


Leu Leu Lys Asp Arg Lys Ala Ser Lys Ser Ser Phe Pro Asp Lys Asp 
                485                 490                 495     


Ser Phe Gly Cys Arg Asn Ile Phe Arg Lys Thr Ser Asp Ser Asn Cys 
            500                 505                 510         


Val Ala Ser Ser Ser Met Glu Phe Ile Pro Val Pro Pro Pro Arg Thr 
        515                 520                 525             


Pro Arg Ile Val Lys Lys Pro Glu Pro His Gln Pro Gly Pro Gly Ser 
    530                 535                 540                 


Thr Gly Ile Pro His Lys Glu Asp Pro Leu Met Leu Asp Met Val Arg 
545                 550                 555                 560 


Ser Phe Glu Ser Val Asp Arg Asp Asp His Val Glu Val Leu Ser Pro 
                565                 570                 575     


Ser His His Tyr Arg Ile Leu Asn Ser Pro Val Ser Leu Ala Arg Arg 
            580                 585                 590         


Asn Ser Ser Glu Arg Thr Leu Ser Pro Gly Leu Pro Ser Gly Ser Met 
        595                 600                 605             


Ser Pro Leu His Thr Pro Leu His Pro Thr Leu Val Ser Phe Ala His 
    610                 615                 620                 


Glu Asp Lys Asn Ser Pro Pro Lys Glu Glu Gly Leu Cys Cys Pro Pro 
625                 630                 635                 640 


Pro Val Pro Ser Asn Gly Pro Met Gln Pro Leu Gly Ser Pro Asn Cys 
                645                 650                 655     


Val Lys Ser Arg Gly Arg Phe Pro Met Met Gly Ile Gly Gln Met Leu 
            660                 665                 670         


Arg Lys Arg His Gln Ser Leu Gln Pro Ser Ala Asp Arg Pro Leu Glu 
        675                 680                 685             


Ala Ser Leu Pro Pro Leu Gln Pro Leu Ala Pro Val Asn Leu Ala Phe 
    690                 695                 700                 


Asp Met Ala Asp Gly Val Lys Thr Gln Cys 
705                 710                 


<210>  5257
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUS1B__Homo_sapiens__NP_683762

<400>  5257

Met Lys Phe Arg Ala Lys Ile Thr Gly Lys Gly Cys Leu Glu Leu Phe 
1               5                   10                  15      


Ile His Val Ser Gly Thr Val Ala Arg Leu Ala Lys Val Cys Val Leu 
            20                  25                  30          


Arg Val Arg Pro Asp Ser Leu Cys Phe Gly Pro Ala Gly Ser Gly Gly 
        35                  40                  45              


Leu His Glu Ala Arg Leu Trp Cys Glu Val Arg Gln Gly Ala Phe Gln 
    50                  55                  60                  


Gln Phe Arg Met Glu Gly Val Ser Glu Asp Leu Asp Glu Ile His Leu 
65                  70                  75                  80  


Glu Leu Thr Ala Glu His Leu Ser Arg Ala Ala Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ser Ser Leu Lys Leu Gln Leu Thr His Lys Arg Arg Pro Ser Leu 
            100                 105                 110         


Thr Val Ala Val Glu Leu Val Ser Ser Leu Gly Arg Ala Arg Ser Val 
        115                 120                 125             


Val His Asp Leu Pro Val Arg Val Leu Pro Arg Arg Val Trp Arg Asp 
    130                 135                 140                 


Cys Leu Pro Pro Ser Leu Arg Ala Ser Asp Ala Ser Ile Arg Leu Pro 
145                 150                 155                 160 


Arg Trp Arg Thr Leu Arg Ser Ile Val Glu Arg Met Ala Asn Val Gly 
                165                 170                 175     


Ser His Val Leu Val Glu Ala Asn Leu Ser Gly Arg Met Thr Leu Ser 
            180                 185                 190         


Ile Glu Thr Glu Val Val Ser Ile Gln Ser Tyr Phe Lys Asn Leu Gly 
        195                 200                 205             


Asn Pro Pro Gln Ser Ala Val Gly Val Pro Glu Asn Arg Asp Leu Glu 
    210                 215                 220                 


Ser Met Val Gln Val Arg Val Asp Asn Arg Lys Leu Leu Gln Phe Leu 
225                 230                 235                 240 


Glu Gly Gln Gln Ile His Pro Thr Thr Ala Leu Cys Asn Ile Trp Asp 
                245                 250                 255     


Asn Thr Leu Leu Gln Leu Val Leu Val Gln Glu Asp Val Ser Leu Gln 
            260                 265                 270         


Tyr Phe Ile Pro Ala Leu 
        275             


<210>  5258
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUS1__Homo_sapiens__NP_004498

<400>  5258

Met Lys Phe Arg Ala Lys Ile Val Asp Gly Ala Cys Leu Asn His Phe 
1               5                   10                  15      


Thr Arg Ile Ser Asn Met Ile Ala Lys Leu Ala Lys Thr Cys Thr Leu 
            20                  25                  30          


Arg Ile Ser Pro Asp Lys Leu Asn Phe Ile Leu Cys Asp Lys Leu Ala 
        35                  40                  45              


Asn Gly Gly Val Ser Met Trp Cys Glu Leu Glu Gln Glu Asn Phe Phe 
    50                  55                  60                  


Asn Glu Phe Gln Met Glu Gly Val Ser Ala Glu Asn Asn Glu Ile Tyr 
65                  70                  75                  80  


Leu Glu Leu Thr Ser Glu Asn Leu Ser Arg Ala Leu Lys Thr Ala Gln 
                85                  90                  95      


Asn Ala Arg Ala Leu Lys Ile Lys Leu Thr Asn Lys His Phe Pro Cys 
            100                 105                 110         


Leu Thr Val Ser Val Glu Leu Leu Ser Met Ser Ser Ser Ser Arg Ile 
        115                 120                 125             


Val Thr His Asp Ile Pro Ile Lys Val Ile Pro Arg Lys Leu Trp Lys 
    130                 135                 140                 


Asp Leu Gln Glu Pro Val Val Pro Asp Pro Asp Val Ser Ile Tyr Leu 
145                 150                 155                 160 


Pro Val Leu Lys Thr Met Lys Ser Val Val Glu Lys Met Lys Asn Ile 
                165                 170                 175     


Ser Asn His Leu Val Ile Glu Ala Asn Leu Asp Gly Glu Leu Asn Leu 
            180                 185                 190         


Lys Ile Glu Thr Glu Leu Val Cys Val Thr Thr His Phe Lys Asp Leu 
        195                 200                 205             


Gly Asn Pro Pro Leu Ala Ser Glu Ser Thr His Glu Asp Arg Asn Val 
    210                 215                 220                 


Glu His Met Ala Glu Val His Ile Asp Ile Arg Lys Leu Leu Gln Phe 
225                 230                 235                 240 


Leu Ala Gly Gln Gln Val Asn Pro Thr Lys Ala Leu Cys Asn Ile Val 
                245                 250                 255     


Asn Asn Lys Met Val His Phe Asp Leu Leu His Glu Asp Val Ser Leu 
            260                 265                 270         


Gln Tyr Phe Ile Pro Ala Leu Ser 
        275                 280 


<210>  5259
<211>  4374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUWE1__Homo_sapiens__XP_005262022

<400>  5259

Met Lys Val Asp Arg Thr Lys Leu Lys Lys Thr Pro Thr Glu Ala Pro 
1               5                   10                  15      


Ala Asp Cys Arg Ala Leu Ile Asp Lys Leu Lys Val Cys Asn Asp Glu 
            20                  25                  30          


Gln Leu Leu Leu Glu Leu Gln Gln Ile Lys Thr Trp Asn Ile Gly Lys 
        35                  40                  45              


Cys Glu Leu Tyr His Trp Val Asp Leu Leu Asp Arg Phe Asp Gly Ile 
    50                  55                  60                  


Leu Ala Asp Ala Gly Gln Thr Val Glu Asn Met Ser Trp Met Leu Val 
65                  70                  75                  80  


Cys Asp Arg Pro Glu Arg Glu Gln Leu Lys Met Leu Leu Leu Ala Val 
                85                  90                  95      


Leu Asn Phe Thr Ala Leu Leu Ile Glu Tyr Ser Phe Ser Arg His Leu 
            100                 105                 110         


Tyr Ser Ser Ile Glu His Leu Thr Thr Leu Leu Ala Ser Ser Asp Met 
        115                 120                 125             


Gln Val Val Leu Ala Val Leu Asn Leu Leu Tyr Val Phe Ser Lys Arg 
    130                 135                 140                 


Ser Asn Tyr Ile Thr Arg Leu Gly Ser Asp Lys Arg Thr Pro Leu Leu 
145                 150                 155                 160 


Thr Arg Leu Gln His Leu Ala Glu Ser Trp Gly Gly Lys Glu Asn Gly 
                165                 170                 175     


Phe Gly Leu Ala Glu Cys Cys Arg Asp Leu His Met Met Lys Tyr Pro 
            180                 185                 190         


Pro Ser Ala Thr Thr Leu His Phe Glu Phe Tyr Ala Asp Pro Gly Ala 
        195                 200                 205             


Glu Val Lys Ile Glu Lys Arg Thr Thr Ser Asn Thr Leu His Tyr Ile 
    210                 215                 220                 


His Ile Glu Gln Leu Asp Lys Ile Ser Glu Ser Pro Ser Glu Ile Met 
225                 230                 235                 240 


Glu Ser Leu Thr Lys Met Tyr Ser Ile Pro Lys Asp Lys Gln Met Leu 
                245                 250                 255     


Leu Phe Thr His Ile Arg Leu Ala His Gly Phe Ser Asn His Arg Lys 
            260                 265                 270         


Arg Leu Gln Ala Val Gln Ala Arg Leu His Ala Ile Ser Ile Leu Val 
        275                 280                 285             


Tyr Ser Asn Ala Leu Gln Glu Ser Ala Asn Ser Ile Leu Tyr Asn Gly 
    290                 295                 300                 


Leu Ile Glu Glu Leu Val Asp Val Leu Gln Ile Thr Asp Lys Gln Leu 
305                 310                 315                 320 


Met Glu Ile Lys Ala Ala Ser Leu Arg Thr Leu Thr Ser Ile Val His 
                325                 330                 335     


Leu Glu Arg Thr Pro Lys Leu Ser Ser Ile Ile Asp Cys Thr Gly Thr 
            340                 345                 350         


Ala Ser Tyr His Gly Phe Leu Pro Val Leu Val Arg Asn Cys Ile Gln 
        355                 360                 365             


Ala Met Ile Asp Pro Ser Met Asp Pro Tyr Pro His Gln Phe Ala Thr 
    370                 375                 380                 


Ala Leu Phe Ser Phe Leu Tyr His Leu Ala Ser Tyr Asp Ala Gly Gly 
385                 390                 395                 400 


Glu Ala Leu Val Ser Cys Gly Met Met Glu Ala Leu Leu Lys Val Ile 
                405                 410                 415     


Lys Phe Leu Gly Asp Glu Gln Asp Gln Ile Thr Phe Val Thr Arg Ala 
            420                 425                 430         


Val Arg Val Val Asp Leu Ile Thr Asn Leu Asp Met Ala Ala Phe Gln 
        435                 440                 445             


Ser His Ser Gly Leu Ser Ile Phe Ile Tyr Arg Leu Glu His Glu Val 
    450                 455                 460                 


Asp Leu Cys Arg Lys Glu Cys Pro Phe Val Ile Lys Pro Lys Ile Gln 
465                 470                 475                 480 


Arg Pro Asn Thr Thr Gln Glu Gly Glu Glu Met Glu Thr Asp Met Asp 
                485                 490                 495     


Gly Val Gln Cys Ile Pro Gln Arg Ala Ala Leu Leu Lys Ser Met Leu 
            500                 505                 510         


Asn Phe Leu Lys Lys Ala Ile Gln Asp Pro Ala Phe Ser Asp Gly Ile 
        515                 520                 525             


Arg His Val Met Asp Gly Ser Leu Pro Thr Ser Leu Lys His Ile Ile 
    530                 535                 540                 


Ser Asn Ala Glu Tyr Tyr Gly Pro Ser Leu Phe Leu Leu Ala Thr Glu 
545                 550                 555                 560 


Val Val Thr Val Phe Val Phe Gln Glu Pro Ser Leu Leu Ser Ser Leu 
                565                 570                 575     


Gln Asp Asn Gly Leu Thr Asp Val Met Leu His Ala Leu Leu Ile Lys 
            580                 585                 590         


Asp Val Pro Ala Thr Arg Glu Val Leu Gly Ser Leu Pro Asn Val Phe 
        595                 600                 605             


Ser Ala Leu Cys Leu Asn Ala Arg Gly Leu Gln Ser Phe Val Gln Cys 
    610                 615                 620                 


Gln Pro Phe Glu Arg Leu Phe Lys Val Leu Leu Ser Pro Asp Tyr Leu 
625                 630                 635                 640 


Pro Ala Met Arg Arg Arg Arg Ser Ser Asp Pro Leu Gly Asp Thr Ala 
                645                 650                 655     


Ser Asn Leu Gly Ser Ala Val Asp Glu Leu Met Arg His Gln Pro Thr 
            660                 665                 670         


Leu Lys Thr Asp Ala Thr Thr Ala Ile Ile Lys Leu Leu Glu Glu Ile 
        675                 680                 685             


Cys Asn Leu Gly Arg Asp Pro Lys Tyr Ile Cys Gln Lys Pro Ser Ile 
    690                 695                 700                 


Gln Lys Ala Asp Gly Thr Ala Thr Ala Pro Pro Pro Arg Ser Asn His 
705                 710                 715                 720 


Ala Ala Glu Glu Ala Ser Ser Glu Asp Glu Glu Glu Glu Glu Val Gln 
                725                 730                 735     


Ala Met Gln Ser Phe Asn Ser Thr Gln Gln Asn Glu Thr Glu Pro Asn 
            740                 745                 750         


Gln Gln Val Val Gly Thr Glu Glu Arg Ile Pro Ile Pro Leu Met Asp 
        755                 760                 765             


Tyr Ile Leu Asn Val Met Lys Phe Val Glu Ser Ile Leu Ser Asn Asn 
    770                 775                 780                 


Thr Thr Asp Asp His Cys Gln Glu Phe Val Asn Gln Lys Gly Leu Leu 
785                 790                 795                 800 


Pro Leu Val Thr Ile Leu Gly Leu Pro Asn Leu Pro Ile Asp Phe Pro 
                805                 810                 815     


Thr Ser Ala Ala Cys Gln Ala Val Ala Gly Val Cys Lys Ser Ile Leu 
            820                 825                 830         


Thr Leu Ser His Glu Pro Lys Val Leu Gln Glu Gly Leu Leu Gln Leu 
        835                 840                 845             


Asp Ser Ile Leu Ser Ser Leu Glu Pro Leu His Arg Pro Ile Glu Ser 
    850                 855                 860                 


Pro Gly Gly Ser Val Leu Leu Arg Glu Leu Ala Cys Ala Gly Asn Val 
865                 870                 875                 880 


Ala Asp Ala Thr Leu Ser Ala Gln Ala Thr Pro Leu Leu His Ala Leu 
                885                 890                 895     


Thr Ala Ala His Ala Tyr Ile Met Met Phe Val His Thr Cys Arg Val 
            900                 905                 910         


Gly Gln Ser Glu Ile Arg Ser Ile Ser Val Asn Gln Trp Gly Ser Gln 
        915                 920                 925             


Leu Gly Leu Ser Val Leu Ser Lys Leu Ser Gln Leu Tyr Cys Ser Leu 
    930                 935                 940                 


Val Trp Glu Ser Thr Val Leu Leu Ser Leu Cys Thr Pro Asn Ser Leu 
945                 950                 955                 960 


Pro Ser Gly Cys Glu Phe Gly Gln Ala Asp Met Gln Lys Leu Val Pro 
                965                 970                 975     


Lys Asp Glu Lys Ala Gly Thr Thr Gln Gly Gly Lys Arg Ser Asp Gly 
            980                 985                 990         


Glu Gln Asp Gly Ala Ala Gly Ser  Met Asp Ala Ser Thr  Gln Gly Leu 
        995                 1000                 1005             


Leu Glu  Gly Ile Gly Leu Asp  Gly Asp Thr Leu Ala  Pro Met Glu 
    1010                 1015                 1020             


Thr Asp  Glu Pro Thr Ala Ser  Asp Ser Lys Gly Lys  Ser Lys Ile 
    1025                 1030                 1035             


Thr Pro  Ala Met Ala Ala Arg  Ile Lys Gln Ile Lys  Pro Leu Leu 
    1040                 1045                 1050             


Ser Ala  Ser Ser Arg Leu Gly  Arg Ala Leu Ala Glu  Leu Phe Gly 
    1055                 1060                 1065             


Leu Leu  Val Lys Leu Cys Val  Gly Ser Pro Val Arg  Gln Arg Arg 
    1070                 1075                 1080             


Ser His  His Ala Ala Ser Thr  Thr Thr Ala Pro Thr  Pro Ala Ala 
    1085                 1090                 1095             


Arg Ser  Thr Ala Ser Ala Leu  Thr Lys Leu Leu Thr  Lys Gly Leu 
    1100                 1105                 1110             


Ser Trp  Gln Pro Pro Pro Tyr  Thr Pro Thr Pro Arg  Phe Arg Leu 
    1115                 1120                 1125             


Thr Phe  Phe Ile Cys Ser Val  Gly Phe Thr Ser Pro  Met Leu Phe 
    1130                 1135                 1140             


Asp Glu  Arg Lys Tyr Pro Tyr  His Leu Met Leu Gln  Lys Phe Leu 
    1145                 1150                 1155             


Cys Ser  Gly Gly His Asn Ala  Leu Phe Glu Thr Phe  Asn Trp Ala 
    1160                 1165                 1170             


Leu Ser  Met Gly Gly Lys Val  Pro Val Ser Glu Gly  Leu Glu His 
    1175                 1180                 1185             


Ser Asp  Leu Pro Asp Gly Thr  Gly Glu Phe Leu Asp  Ala Trp Leu 
    1190                 1195                 1200             


Met Leu  Val Glu Lys Met Val  Asn Pro Thr Thr Val  Leu Glu Ser 
    1205                 1210                 1215             


Pro His  Ser Leu Pro Ala Lys  Leu Pro Gly Gly Val  Gln Asn Phe 
    1220                 1225                 1230             


Pro Gln  Phe Ser Ala Leu Arg  Phe Leu Val Val Thr  Gln Lys Ala 
    1235                 1240                 1245             


Ala Phe  Thr Cys Ile Lys Asn  Leu Trp Asn Arg Lys  Pro Leu Lys 
    1250                 1255                 1260             


Val Tyr  Gly Gly Arg Met Ala  Glu Ser Met Leu Ala  Ile Leu Cys 
    1265                 1270                 1275             


His Ile  Leu Arg Gly Glu Pro  Val Ile Arg Glu Arg  Leu Ser Lys 
    1280                 1285                 1290             


Glu Lys  Glu Gly Ser Arg Gly  Glu Glu Asp Thr Gly  Gln Glu Glu 
    1295                 1300                 1305             


Gly Gly  Ser Arg Arg Glu Pro  Gln Val Asn Gln Gln  Gln Leu Gln 
    1310                 1315                 1320             


Gln Leu  Met Asp Met Gly Phe  Thr Arg Glu His Ala  Met Glu Ala 
    1325                 1330                 1335             


Leu Leu  Asn Thr Ser Thr Met  Glu Gln Ala Thr Glu  Tyr Leu Leu 
    1340                 1345                 1350             


Thr His  Pro Pro Pro Ile Met  Gly Gly Val Val Arg  Asp Leu Ser 
    1355                 1360                 1365             


Met Ser  Glu Glu Asp Gln Met  Met Arg Ala Ile Ala  Met Ser Leu 
    1370                 1375                 1380             


Gly Gln  Asp Ile Pro Met Asp  Gln Arg Ala Glu Ser  Pro Glu Glu 
    1385                 1390                 1395             


Val Ala  Cys Arg Lys Glu Glu  Glu Glu Arg Lys Ala  Arg Glu Lys 
    1400                 1405                 1410             


Gln Glu  Glu Glu Glu Ala Lys  Cys Leu Glu Lys Phe  Gln Asp Ala 
    1415                 1420                 1425             


Asp Pro  Leu Glu Gln Asp Glu  Leu His Thr Phe Thr  Asp Thr Met 
    1430                 1435                 1440             


Leu Pro  Gly Cys Phe His Leu  Leu Asp Glu Leu Pro  Asp Thr Val 
    1445                 1450                 1455             


Tyr Arg  Val Cys Asp Leu Ile  Met Thr Ala Ile Lys  Arg Asn Gly 
    1460                 1465                 1470             


Ala Asp  Tyr Arg Asp Met Ile  Leu Lys Gln Val Val  Asn Gln Val 
    1475                 1480                 1485             


Trp Glu  Ala Ala Asp Val Leu  Ile Lys Ala Ala Leu  Pro Leu Thr 
    1490                 1495                 1500             


Thr Ser  Asp Thr Lys Thr Val  Ser Glu Trp Ile Ser  Gln Met Ala 
    1505                 1510                 1515             


Thr Leu  Pro Gln Ala Ser Asn  Leu Ala Thr Arg Ile  Leu Leu Leu 
    1520                 1525                 1530             


Thr Leu  Leu Phe Glu Glu Leu  Lys Leu Pro Cys Ala  Trp Val Val 
    1535                 1540                 1545             


Glu Ser  Ser Gly Ile Leu Asn  Val Leu Ile Lys Leu  Leu Glu Val 
    1550                 1555                 1560             


Val Gln  Pro Cys Leu Gln Ala  Ala Lys Glu Gln Lys  Glu Val Gln 
    1565                 1570                 1575             


Thr Pro  Lys Trp Ile Thr Pro  Val Leu Leu Leu Ile  Asp Phe Tyr 
    1580                 1585                 1590             


Glu Lys  Thr Ala Ile Ser Ser  Lys Arg Arg Ala Gln  Met Thr Lys 
    1595                 1600                 1605             


Tyr Leu  Gln Ser Asn Ser Asn  Asn Trp Arg Trp Phe  Asp Asp Arg 
    1610                 1615                 1620             


Ser Gly  Arg Trp Cys Ser Tyr  Ser Ala Ser Asn Asn  Ser Thr Ile 
    1625                 1630                 1635             


Asp Ser  Ala Trp Lys Ser Gly  Glu Thr Ser Val Arg  Phe Thr Ala 
    1640                 1645                 1650             


Gly Arg  Arg Arg Tyr Thr Val  Gln Phe Thr Thr Met  Val Gln Val 
    1655                 1660                 1665             


Asn Glu  Glu Thr Gly Asn Arg  Arg Pro Val Met Leu  Thr Leu Leu 
    1670                 1675                 1680             


Arg Val  Pro Arg Leu Asn Lys  Asn Ser Lys Asn Ser  Asn Gly Gln 
    1685                 1690                 1695             


Glu Leu  Glu Lys Thr Leu Glu  Glu Ser Lys Glu Met  Asp Ile Lys 
    1700                 1705                 1710             


Arg Lys  Glu Asn Lys Gly Asn  Asp Thr Pro Leu Ala  Leu Glu Ser 
    1715                 1720                 1725             


Thr Asn  Thr Glu Lys Glu Thr  Ser Leu Glu Glu Thr  Lys Ile Gly 
    1730                 1735                 1740             


Glu Ile  Leu Ile Gln Gly Leu  Thr Glu Asp Met Val  Thr Val Leu 
    1745                 1750                 1755             


Ile Arg  Ala Cys Val Ser Met  Leu Gly Val Pro Val  Asp Pro Asp 
    1760                 1765                 1770             


Thr Leu  His Ala Thr Leu Arg  Leu Cys Leu Arg Leu  Thr Arg Asp 
    1775                 1780                 1785             


His Lys  Tyr Ala Met Met Phe  Ala Glu Leu Lys Ser  Thr Arg Met 
    1790                 1795                 1800             


Ile Leu  Asn Leu Thr Gln Ser  Ser Gly Phe Asn Gly  Phe Thr Pro 
    1805                 1810                 1815             


Leu Val  Thr Leu Leu Leu Arg  His Ile Ile Glu Asp  Pro Cys Thr 
    1820                 1825                 1830             


Leu Arg  His Thr Met Glu Lys  Val Val Arg Ser Ala  Ala Thr Ser 
    1835                 1840                 1845             


Gly Ala  Gly Ser Thr Thr Ser  Gly Val Val Ser Gly  Ser Leu Gly 
    1850                 1855                 1860             


Ser Arg  Glu Ile Asn Tyr Ile  Leu Arg Val Leu Gly  Pro Ala Ala 
    1865                 1870                 1875             


Cys Arg  Asn Pro Asp Ile Phe  Thr Glu Val Ala Asn  Cys Cys Ile 
    1880                 1885                 1890             


Arg Ile  Ala Leu Pro Ala Pro  Arg Gly Ser Gly Thr  Ala Ser Asp 
    1895                 1900                 1905             


Asp Glu  Phe Glu Asn Leu Arg  Ile Lys Gly Pro Asn  Ala Val Gln 
    1910                 1915                 1920             


Leu Val  Lys Thr Thr Pro Leu  Lys Pro Ser Pro Leu  Pro Val Ile 
    1925                 1930                 1935             


Pro Asp  Thr Ile Lys Glu Val  Ile Tyr Asp Met Leu  Asn Ala Leu 
    1940                 1945                 1950             


Ala Ala  Tyr His Ala Pro Glu  Glu Ala Asp Lys Ser  Asp Pro Lys 
    1955                 1960                 1965             


Pro Gly  Val Met Thr Gln Glu  Val Gly Gln Leu Leu  Gln Asp Met 
    1970                 1975                 1980             


Gly Asp  Asp Val Tyr Gln Gln  Tyr Arg Ser Leu Thr  Arg Gln Ser 
    1985                 1990                 1995             


Ser Asp  Phe Asp Thr Gln Ser  Gly Phe Ser Ile Asn  Ser Gln Val 
    2000                 2005                 2010             


Phe Ala  Ala Asp Gly Ala Ser  Thr Glu Thr Ser Ala  Ser Gly Thr 
    2015                 2020                 2025             


Ser Gln  Gly Glu Ala Ser Thr  Pro Glu Glu Ser Arg  Asp Gly Lys 
    2030                 2035                 2040             


Lys Asp  Lys Glu Gly Asp Arg  Ala Ser Glu Glu Gly  Lys Gln Lys 
    2045                 2050                 2055             


Gly Lys  Gly Ser Lys Pro Leu  Met Pro Thr Ser Thr  Ile Leu Arg 
    2060                 2065                 2070             


Leu Leu  Ala Glu Leu Val Arg  Ser Tyr Val Gly Ile  Ala Thr Leu 
    2075                 2080                 2085             


Ile Ala  Asn Tyr Ser Tyr Thr  Val Gly Gln Ser Glu  Leu Ile Lys 
    2090                 2095                 2100             


Glu Asp  Cys Ser Val Leu Ala  Phe Val Leu Asp His  Leu Leu Pro 
    2105                 2110                 2115             


His Thr  Gln Asn Ala Glu Asp  Lys Asp Thr Pro Ala  Leu Ala Arg 
    2120                 2125                 2130             


Leu Phe  Leu Ala Ser Leu Ala  Ala Ala Gly Ser Gly  Thr Asp Ala 
    2135                 2140                 2145             


Gln Val  Ala Leu Val Asn Glu  Val Lys Ala Ala Leu  Gly Arg Ala 
    2150                 2155                 2160             


Leu Ala  Met Ala Glu Ser Thr  Glu Lys His Ala Arg  Leu Gln Ala 
    2165                 2170                 2175             


Val Met  Cys Ile Ile Ser Thr  Ile Met Glu Ser Cys  Pro Ser Thr 
    2180                 2185                 2190             


Ser Ser  Phe Tyr Ser Ser Ala  Thr Ala Lys Thr Gln  His Asn Gly 
    2195                 2200                 2205             


Met Asn  Asn Ile Ile Arg Leu  Phe Leu Lys Lys Gly  Leu Val Asn 
    2210                 2215                 2220             


Asp Leu  Ala Arg Val Pro His  Ser Leu Asp Leu Ser  Ser Pro Asn 
    2225                 2230                 2235             


Met Ala  Asn Thr Val Asn Ala  Ala Leu Lys Pro Leu  Glu Thr Leu 
    2240                 2245                 2250             


Ser Arg  Ile Val Asn Gln Pro  Ser Ser Leu Phe Gly  Ser Lys Ser 
    2255                 2260                 2265             


Ala Ser  Ser Lys Asn Lys Ser  Glu Gln Asp Ala Gln  Gly Ala Ser 
    2270                 2275                 2280             


Gln Asp  Ser Ser Ser Asn Gln  Gln Asp Pro Gly Glu  Pro Gly Glu 
    2285                 2290                 2295             


Ala Glu  Val Gln Glu Glu Asp  His Asp Val Thr Gln  Thr Glu Val 
    2300                 2305                 2310             


Ala Asp  Gly Asp Ile Met Asp  Gly Glu Ala Glu Thr  Asp Ser Val 
    2315                 2320                 2325             


Val Ile  Ala Gly Gln Pro Glu  Val Leu Ser Ser Gln  Glu Met Gln 
    2330                 2335                 2340             


Val Glu  Asn Glu Leu Glu Asp  Leu Ile Asp Glu Leu  Leu Glu Arg 
    2345                 2350                 2355             


Asp Gly  Gly Ser Gly Asn Ser  Thr Ile Ile Val Ser  Arg Ser Gly 
    2360                 2365                 2370             


Glu Asp  Glu Ser Gln Glu Asp  Val Leu Met Asp Glu  Ala Pro Ser 
    2375                 2380                 2385             


Asn Leu  Ser Gln Ala Ser Thr  Leu Gln Ala Asn Arg  Glu Asp Ser 
    2390                 2395                 2400             


Met Asn  Ile Leu Asp Pro Glu  Asp Glu Glu Glu His  Thr Gln Glu 
    2405                 2410                 2415             


Glu Asp  Ser Ser Gly Ser Asn  Glu Asp Glu Asp Asp  Ser Gln Asp 
    2420                 2425                 2430             


Glu Glu  Glu Glu Glu Glu Glu  Asp Glu Glu Asp Asp  Gln Glu Asp 
    2435                 2440                 2445             


Asp Glu  Gly Glu Glu Gly Asp  Glu Asp Asp Asp Asp  Asp Gly Ser 
    2450                 2455                 2460             


Glu Met  Glu Leu Asp Glu Asp  Tyr Pro Asp Met Asn  Ala Ser Pro 
    2465                 2470                 2475             


Leu Val  Arg Phe Glu Arg Phe  Asp Arg Glu Asp Asp  Leu Ile Ile 
    2480                 2485                 2490             


Glu Phe  Asp Asn Met Phe Ser  Ser Ala Thr Asp Ile  Pro Pro Ser 
    2495                 2500                 2505             


Pro Gly  Asn Ile Pro Thr Thr  His Pro Leu Met Val  Arg His Ala 
    2510                 2515                 2520             


Asp His  Ser Ser Leu Thr Leu  Gly Ser Gly Ser Ser  Thr Thr Arg 
    2525                 2530                 2535             


Leu Thr  Gln Gly Ile Gly Arg  Ser Gln Arg Thr Leu  Arg Gln Leu 
    2540                 2545                 2550             


Thr Ala  Asn Thr Gly His Thr  Ile His Val His Tyr  Pro Gly Asn 
    2555                 2560                 2565             


Arg Gln  Pro Asn Pro Pro Leu  Ile Leu Gln Arg Leu  Leu Gly Pro 
    2570                 2575                 2580             


Ser Ala  Ala Ala Asp Ile Leu  Gln Leu Ser Ser Ser  Leu Pro Leu 
    2585                 2590                 2595             


Gln Ser  Arg Gly Arg Ala Arg  Leu Leu Val Gly Asn  Asp Asp Val 
    2600                 2605                 2610             


His Ile  Ile Ala Arg Ser Asp  Asp Glu Leu Leu Asp  Asp Phe Phe 
    2615                 2620                 2625             


His Asp  Gln Ser Thr Ala Thr  Ser Gln Ala Gly Thr  Leu Ser Ser 
    2630                 2635                 2640             


Ile Pro  Thr Ala Leu Thr Arg  Trp Thr Glu Glu Cys  Lys Val Leu 
    2645                 2650                 2655             


Asp Ala  Glu Ser Met His Asp  Cys Val Ser Val Val  Lys Val Ser 
    2660                 2665                 2670             


Ile Val  Asn His Leu Glu Phe  Leu Arg Asp Glu Glu  Leu Glu Glu 
    2675                 2680                 2685             


Arg Arg  Glu Lys Arg Arg Lys  Gln Leu Ala Glu Glu  Glu Thr Lys 
    2690                 2695                 2700             


Ile Thr  Asp Lys Gly Lys Glu  Asp Lys Glu Asn Arg  Asp Gln Ser 
    2705                 2710                 2715             


Ala Gln  Cys Thr Ala Ser Lys  Ser Asn Asp Ser Thr  Glu Gln Asn 
    2720                 2725                 2730             


Leu Ser  Asp Gly Thr Pro Met  Pro Asp Ser Tyr Pro  Thr Thr Pro 
    2735                 2740                 2745             


Ser Ser  Thr Asp Ala Ala Thr  Ser Glu Ser Lys Glu  Thr Leu Gly 
    2750                 2755                 2760             


Thr Leu  Gln Ser Ser Gln Gln  Gln Pro Thr Leu Pro  Thr Pro Pro 
    2765                 2770                 2775             


Ala Leu  Gly Glu Val Pro Gln  Glu Leu Gln Ser Pro  Ala Gly Glu 
    2780                 2785                 2790             


Gly Gly  Ser Ser Thr Gln Leu  Leu Met Pro Val Glu  Pro Glu Glu 
    2795                 2800                 2805             


Leu Gly  Pro Thr Arg Pro Ser  Gly Glu Ala Glu Thr  Thr Gln Met 
    2810                 2815                 2820             


Glu Leu  Ser Pro Ala Pro Thr  Ile Thr Ser Leu Ser  Pro Glu Arg 
    2825                 2830                 2835             


Ala Glu  Asp Ser Asp Ala Leu  Thr Ala Val Ser Ser  Gln Leu Glu 
    2840                 2845                 2850             


Gly Ser  Pro Met Asp Thr Ser  Ser Leu Ala Ser Cys  Thr Leu Glu 
    2855                 2860                 2865             


Glu Ala  Val Gly Asp Thr Ser  Ala Ala Gly Ser Ser  Glu Gln Pro 
    2870                 2875                 2880             


Arg Ala  Gly Ser Ser Thr Pro  Gly Asp Ala Pro Pro  Ala Val Ala 
    2885                 2890                 2895             


Glu Val  Gln Gly Arg Ser Asp  Gly Ser Gly Glu Ser  Ala Gln Pro 
    2900                 2905                 2910             


Pro Glu  Asp Ser Ser Pro Pro  Ala Ser Ser Glu Ser  Ser Ser Thr 
    2915                 2920                 2925             


Arg Asp  Ser Ala Val Ala Ile  Ser Gly Ala Asp Ser  Arg Gly Ile 
    2930                 2935                 2940             


Leu Glu  Glu Pro Leu Pro Ser  Thr Ser Ser Glu Glu  Glu Asp Pro 
    2945                 2950                 2955             


Leu Ala  Gly Ile Ser Leu Pro  Glu Gly Val Asp Pro  Ser Phe Leu 
    2960                 2965                 2970             


Ala Ala  Leu Pro Asp Asp Ile  Arg Arg Glu Val Leu  Gln Asn Gln 
    2975                 2980                 2985             


Leu Gly  Ile Arg Pro Pro Thr  Arg Thr Ala Pro Ser  Thr Asn Ser 
    2990                 2995                 3000             


Ser Ala  Pro Ala Val Val Gly  Asn Pro Gly Val Thr  Glu Val Ser 
    3005                 3010                 3015             


Pro Glu  Phe Leu Ala Ala Leu  Pro Pro Ala Ile Gln  Glu Glu Val 
    3020                 3025                 3030             


Leu Ala  Gln Gln Arg Ala Glu  Gln Gln Arg Arg Glu  Leu Ala Gln 
    3035                 3040                 3045             


Asn Ala  Ser Ser Asp Thr Pro  Met Asp Pro Val Thr  Phe Ile Gln 
    3050                 3055                 3060             


Thr Leu  Pro Ser Asp Leu Arg  Arg Ser Val Leu Glu  Asp Met Glu 
    3065                 3070                 3075             


Asp Ser  Val Leu Ala Val Met  Pro Pro Asp Ile Ala  Ala Glu Ala 
    3080                 3085                 3090             


Gln Ala  Leu Arg Arg Glu Gln  Glu Ala Arg Gln Arg  Gln Leu Met 
    3095                 3100                 3105             


His Glu  Arg Leu Phe Gly His  Ser Ser Thr Ser Ala  Leu Ser Ala 
    3110                 3115                 3120             


Ile Leu  Arg Ser Pro Ala Phe  Thr Ser Arg Leu Ser  Gly Asn Arg 
    3125                 3130                 3135             


Gly Val  Gln Tyr Thr Arg Leu  Ala Val Gln Arg Gly  Gly Thr Phe 
    3140                 3145                 3150             


Gln Met  Gly Gly Ser Ser Ser  His Asn Arg Pro Ser  Gly Ser Asn 
    3155                 3160                 3165             


Val Asp  Thr Leu Leu Arg Leu  Arg Gly Arg Leu Leu  Leu Asp His 
    3170                 3175                 3180             


Glu Ala  Leu Ser Cys Leu Leu  Val Leu Leu Phe Val  Asp Glu Pro 
    3185                 3190                 3195             


Lys Leu  Asn Thr Ser Arg Leu  His Arg Val Leu Arg  Asn Leu Cys 
    3200                 3205                 3210             


Tyr His  Ala Gln Thr Arg His  Trp Val Ile Arg Ser  Leu Leu Ser 
    3215                 3220                 3225             


Ile Leu  Gln Arg Ser Ser Glu  Ser Glu Leu Cys Ile  Glu Thr Pro 
    3230                 3235                 3240             


Lys Leu  Thr Thr Ser Glu Glu  Lys Gly Lys Lys Ser  Ser Lys Ser 
    3245                 3250                 3255             


Cys Gly  Ser Ser Ser His Glu  Asn Arg Pro Leu Asp  Leu Leu His 
    3260                 3265                 3270             


Lys Met  Glu Ser Lys Ser Ser  Asn Gln Leu Ser Trp  Leu Ser Val 
    3275                 3280                 3285             


Ser Met  Asp Ala Ala Leu Gly  Cys Arg Thr Asn Ile  Phe Gln Ile 
    3290                 3295                 3300             


Gln Arg  Ser Gly Gly Arg Lys  His Thr Glu Lys His  Ala Ser Gly 
    3305                 3310                 3315             


Gly Ser  Thr Val His Ile His  Pro Gln Ala Ala Pro  Val Val Cys 
    3320                 3325                 3330             


Arg His  Val Leu Asp Thr Leu  Ile Gln Leu Ala Lys  Val Phe Pro 
    3335                 3340                 3345             


Ser His  Phe Thr Gln Gln Arg  Thr Lys Glu Thr Asn  Cys Glu Ser 
    3350                 3355                 3360             


Asp Arg  Glu Arg Gly Asn Lys  Ala Cys Ser Pro Cys  Ser Ser Gln 
    3365                 3370                 3375             


Ser Ser  Ser Ser Gly Ile Cys  Thr Asp Phe Trp Asp  Leu Leu Val 
    3380                 3385                 3390             


Lys Leu  Asp Asn Met Asn Val  Ser Arg Lys Gly Lys  Asn Ser Val 
    3395                 3400                 3405             


Lys Ser  Val Pro Val Ser Ala  Gly Gly Glu Gly Glu  Thr Ser Pro 
    3410                 3415                 3420             


Tyr Ser  Leu Glu Ala Ser Pro  Leu Gly Gln Leu Met  Asn Met Leu 
    3425                 3430                 3435             


Ser His  Pro Val Ile Arg Arg  Ser Ser Leu Leu Thr  Glu Lys Leu 
    3440                 3445                 3450             


Leu Arg  Leu Leu Ser Leu Ile  Ser Ile Ala Leu Pro  Glu Asn Lys 
    3455                 3460                 3465             


Val Ser  Glu Ala Gln Ala Asn  Ser Gly Ser Gly Ala  Ser Ser Thr 
    3470                 3475                 3480             


Thr Thr  Ala Thr Ser Thr Thr  Ser Thr Thr Thr Thr  Thr Ala Ala 
    3485                 3490                 3495             


Ser Thr  Thr Pro Thr Pro Pro  Thr Ala Pro Thr Pro  Val Thr Ser 
    3500                 3505                 3510             


Ala Pro  Ala Leu Val Ala Ala  Thr Ala Ile Ser Thr  Ile Val Val 
    3515                 3520                 3525             


Ala Ala  Ser Thr Thr Val Thr  Thr Pro Thr Thr Ala  Thr Thr Thr 
    3530                 3535                 3540             


Val Ser  Ile Ser Pro Thr Thr  Lys Gly Ser Lys Ser  Pro Ala Lys 
    3545                 3550                 3555             


Val Ser  Asp Gly Gly Ser Ser  Ser Thr Asp Phe Lys  Met Val Ser 
    3560                 3565                 3570             


Ser Gly  Leu Thr Glu Asn Gln  Leu Gln Leu Ser Val  Glu Val Leu 
    3575                 3580                 3585             


Thr Ser  His Ser Cys Ser Glu  Glu Gly Leu Glu Asp  Ala Ala Asn 
    3590                 3595                 3600             


Val Leu  Leu Gln Leu Ser Arg  Gly Asp Ser Gly Thr  Arg Asp Thr 
    3605                 3610                 3615             


Val Leu  Lys Leu Leu Leu Asn  Gly Ala Arg His Leu  Gly Tyr Thr 
    3620                 3625                 3630             


Leu Cys  Lys Gln Ile Gly Thr  Leu Leu Ala Glu Leu  Arg Glu Tyr 
    3635                 3640                 3645             


Asn Leu  Glu Gln Gln Arg Arg  Ala Gln Cys Glu Thr  Leu Ser Pro 
    3650                 3655                 3660             


Asp Gly  Leu Pro Glu Glu Gln  Pro Gln Thr Thr Lys  Leu Lys Gly 
    3665                 3670                 3675             


Lys Met  Gln Ser Arg Phe Asp  Met Ala Glu Asn Val  Val Ile Val 
    3680                 3685                 3690             


Ala Ser  Gln Lys Arg Pro Leu  Gly Gly Arg Glu Leu  Gln Leu Pro 
    3695                 3700                 3705             


Ser Met  Ser Met Leu Thr Ser  Lys Thr Ser Thr Gln  Lys Phe Phe 
    3710                 3715                 3720             


Leu Arg  Val Leu Gln Val Ile  Ile Gln Leu Arg Asp  Asp Thr Arg 
    3725                 3730                 3735             


Arg Ala  Asn Lys Lys Ala Lys  Gln Thr Gly Arg Leu  Gly Ser Ser 
    3740                 3745                 3750             


Gly Leu  Gly Ser Ala Ser Ser  Ile Gln Ala Ala Val  Arg Gln Leu 
    3755                 3760                 3765             


Glu Ala  Glu Ala Asp Ala Ile  Ile Gln Met Val Arg  Glu Gly Gln 
    3770                 3775                 3780             


Arg Ala  Arg Arg Gln Gln Gln  Ala Ala Thr Ser Glu  Ser Ser Gln 
    3785                 3790                 3795             


Ser Glu  Ala Ser Val Arg Arg  Glu Glu Ser Pro Met  Asp Val Asp 
    3800                 3805                 3810             


Gln Pro  Ser Pro Ser Ala Gln  Asp Thr Gln Ser Ile  Ala Ser Asp 
    3815                 3820                 3825             


Gly Thr  Pro Gln Gly Glu Lys  Glu Lys Glu Glu Arg  Pro Pro Glu 
    3830                 3835                 3840             


Leu Pro  Leu Leu Ser Glu Gln  Leu Ser Leu Asp Glu  Leu Trp Asp 
    3845                 3850                 3855             


Met Leu  Gly Glu Cys Leu Lys  Glu Leu Glu Glu Ser  His Asp Gln 
    3860                 3865                 3870             


His Ala  Val Leu Val Leu Gln  Pro Ala Val Glu Ala  Phe Phe Leu 
    3875                 3880                 3885             


Val His  Ala Thr Glu Arg Glu  Ser Lys Pro Pro Val  Arg Asp Thr 
    3890                 3895                 3900             


Arg Glu  Ser Gln Leu Ala His  Ile Lys Asp Glu Pro  Pro Pro Leu 
    3905                 3910                 3915             


Ser Pro  Ala Pro Leu Thr Pro  Ala Thr Pro Ser Ser  Leu Asp Pro 
    3920                 3925                 3930             


Phe Phe  Ser Arg Glu Pro Ser  Ser Met His Ile Ser  Ser Ser Leu 
    3935                 3940                 3945             


Pro Pro  Asp Thr Gln Lys Phe  Leu Arg Phe Ala Glu  Thr His Arg 
    3950                 3955                 3960             


Thr Val  Leu Asn Gln Ile Leu  Arg Gln Ser Thr Thr  His Leu Ala 
    3965                 3970                 3975             


Asp Gly  Pro Phe Ala Val Leu  Val Asp Tyr Ile Arg  Val Leu Asp 
    3980                 3985                 3990             


Phe Asp  Val Lys Arg Lys Tyr  Phe Arg Gln Glu Leu  Glu Arg Leu 
    3995                 4000                 4005             


Asp Glu  Gly Leu Arg Lys Glu  Asp Met Ala Val His  Val Arg Arg 
    4010                 4015                 4020             


Asp His  Val Phe Glu Asp Ser  Tyr Arg Glu Leu His  Arg Lys Ser 
    4025                 4030                 4035             


Pro Glu  Glu Met Lys Asn Arg  Leu Tyr Ile Val Phe  Glu Gly Glu 
    4040                 4045                 4050             


Glu Gly  Gln Asp Ala Gly Gly  Leu Leu Arg Glu Trp  Tyr Met Ile 
    4055                 4060                 4065             


Ile Ser  Arg Glu Met Phe Asn  Pro Met Tyr Ala Leu  Phe Arg Thr 
    4070                 4075                 4080             


Ser Pro  Gly Asp Arg Val Thr  Tyr Thr Ile Asn Pro  Ser Ser His 
    4085                 4090                 4095             


Cys Asn  Pro Asn His Leu Ser  Tyr Phe Lys Phe Val  Gly Arg Ile 
    4100                 4105                 4110             


Val Ala  Lys Ala Val Tyr Asp  Asn Arg Leu Leu Glu  Cys Tyr Phe 
    4115                 4120                 4125             


Thr Arg  Ser Phe Tyr Lys His  Ile Leu Gly Lys Ser  Val Arg Tyr 
    4130                 4135                 4140             


Thr Asp  Met Glu Ser Glu Asp  Tyr His Phe Tyr Gln  Gly Leu Val 
    4145                 4150                 4155             


Tyr Leu  Leu Glu Asn Asp Val  Ser Thr Leu Gly Tyr  Asp Leu Thr 
    4160                 4165                 4170             


Phe Ser  Thr Glu Val Gln Glu  Phe Gly Val Cys Glu  Val Arg Asp 
    4175                 4180                 4185             


Leu Lys  Pro Asn Gly Ala Asn  Ile Leu Val Thr Glu  Glu Asn Lys 
    4190                 4195                 4200             


Lys Glu  Tyr Val His Leu Val  Cys Gln Met Arg Met  Thr Gly Ala 
    4205                 4210                 4215             


Ile Arg  Lys Gln Leu Ala Ala  Phe Leu Glu Gly Phe  Tyr Glu Ile 
    4220                 4225                 4230             


Ile Pro  Lys Arg Leu Ile Ser  Ile Phe Thr Glu Gln  Glu Leu Glu 
    4235                 4240                 4245             


Leu Leu  Ile Ser Gly Leu Pro  Thr Ile Asp Ile Asp  Asp Leu Lys 
    4250                 4255                 4260             


Ser Asn  Thr Glu Tyr His Lys  Tyr Gln Ser Asn Ser  Ile Gln Ile 
    4265                 4270                 4275             


Gln Trp  Phe Trp Arg Ala Leu  Arg Ser Phe Asp Gln  Ala Asp Arg 
    4280                 4285                 4290             


Ala Lys  Phe Leu Gln Phe Val  Thr Gly Thr Ser Lys  Val Pro Leu 
    4295                 4300                 4305             


Gln Gly  Phe Ala Ala Leu Glu  Gly Met Asn Gly Ile  Gln Lys Phe 
    4310                 4315                 4320             


Gln Ile  His Arg Asp Asp Arg  Ser Thr Asp Arg Leu  Pro Ser Ala 
    4325                 4330                 4335             


His Thr  Cys Phe Asn Gln Leu  Asp Leu Pro Ala Tyr  Glu Ser Phe 
    4340                 4345                 4350             


Glu Lys  Leu Arg His Met Leu  Leu Leu Ala Ile Gln  Glu Cys Ser 
    4355                 4360                 4365             


Glu Gly  Phe Gly Leu Ala 
    4370                 


<210>  5260
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVCN1__Homo_sapiens__XP_011537150

<400>  5260

Met Ala Thr Trp Asp Glu Lys Ala Val Thr Arg Arg Ala Lys Val Ala 
1               5                   10                  15      


Pro Ala Glu Arg Met Ser Lys Phe Leu Arg His Phe Thr Val Val Gly 
            20                  25                  30          


Asp Asp Tyr His Ala Trp Asn Ile Asn Tyr Lys Lys Trp Glu Asn Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Gln Pro Pro Pro Thr Pro Val Ser Gly 
    50                  55                  60                  


Glu Glu Gly Arg Ala Ala Ala Pro Asp Val Ala Pro Ala Pro Gly Pro 
65                  70                  75                  80  


Ala Pro Arg Ala Pro Leu Asp Phe Arg Gly Met Leu Arg Lys Leu Phe 
                85                  90                  95      


Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu Val Val Leu Asp 
            100                 105                 110         


Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu Lys Ile Ile Gln 
        115                 120                 125             


Pro Asp Lys Asn Asn Tyr Ala Ala Met Val Phe His Tyr Met Ser Ile 
    130                 135                 140                 


Thr Ile Leu Val Phe Phe Met Met Glu Ile Ile Phe Lys Leu Phe Val 
145                 150                 155                 160 


Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile Leu Asp Ala Val 
                165                 170                 175     


Val Val Val Val Ser Phe Ile Leu Asp Ile Val Leu Leu Phe Gln Glu 
            180                 185                 190         


His Gln Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu Arg Leu Trp Arg 
        195                 200                 205             


Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val Lys Thr Arg Ser 
    210                 215                 220                 


Glu Arg Gln Leu Leu Arg Leu Lys Gln Met Asn Val Gln Leu Ala Ala 
225                 230                 235                 240 


Lys Ile Gln His Leu Glu Phe Ser Cys Ser Glu Lys Glu Gln Glu Ile 
                245                 250                 255     


Glu Arg Leu Asn Lys Leu Leu Arg Gln His Gly Leu Leu Gly Glu Val 
            260                 265                 270         


Asn 
    


<210>  5261
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYAL1__Homo_sapiens__NP_149349

<400>  5261

Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu 
1               5                   10                  15      


Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
            20                  25                  30          


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
        35                  40                  45              


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
    50                  55                  60                  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
            100                 105                 110         


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
        115                 120                 125             


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
    130                 135                 140                 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
145                 150                 155                 160 


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
                165                 170                 175     


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
            180                 185                 190         


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
        195                 200                 205             


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
    210                 215                 220                 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
225                 230                 235                 240 


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
                245                 250                 255     


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
            260                 265                 270         


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
        275                 280                 285             


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
    290                 295                 300                 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
305                 310                 315                 320 


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
                325                 330                 335     


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
            340                 345                 350         


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
        355                 360                 365             


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
    370                 375                 380                 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
                405                 410                 415     


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
            420                 425                 430         


Ser Met Trp 
        435 


<210>  5262
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYAL2__Homo_sapiens__XP_005265582

<400>  5262

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210>  5263
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYAL3__Homo_sapiens__NP_001186959

<400>  5263

Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys 
1               5                   10                  15      


Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser 
            20                  25                  30          


Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val 
        35                  40                  45              


His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His 
    50                  55                  60                  


Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu 
65                  70                  75                  80  


Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro 
                85                  90                  95      


Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile 
            100                 105                 110         


His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp 
        115                 120                 125             


Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala 
    130                 135                 140                 


Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu 
145                 150                 155                 160 


Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala 
                165                 170                 175     


Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg 
            180                 185                 190         


Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly 
        195                 200                 205             


Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr 
    210                 215                 220                 


Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala 
225                 230                 235                 240 


Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His 
                245                 250                 255     


Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu 
            260                 265                 270         


Val Gly His Arg His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr 
        275                 280                 285             


His Arg Arg Ser Gly Arg Phe Leu Ser Gln Glu Glu Cys Trp His Leu 
    290                 295                 300                 


His Asp Tyr Leu Val Asp Thr Leu Gly Pro Tyr Val Ile Asn Val Thr 
305                 310                 315                 320 


Arg Ala Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg 
                325                 330                 335     


Cys Ala Arg Arg Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp 
            340                 345                 350         


Pro Asp Gly Ser Leu Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr 
        355                 360                 365             


Trp Gly Trp Ala Gly Pro Thr Cys Gln Glu Pro Arg Pro Gly Pro Lys 
    370                 375                 380                 


Glu Ala Val 
385         


<210>  5264
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYAL4__Homo_sapiens__XP_011514292

<400>  5264

Met Lys Val Leu Ser Glu Gly Gln Leu Lys Leu Cys Val Val Gln Pro 
1               5                   10                  15      


Val His Leu Thr Ser Trp Leu Leu Ile Phe Phe Ile Leu Lys Ser Ile 
            20                  25                  30          


Ser Cys Leu Lys Pro Ala Arg Leu Pro Ile Tyr Gln Arg Lys Pro Phe 
        35                  40                  45              


Ile Ala Ala Trp Asn Ala Pro Thr Asp Gln Cys Leu Ile Lys Tyr Asn 
    50                  55                  60                  


Leu Arg Leu Asn Leu Lys Met Phe Pro Val Ile Gly Ser Pro Leu Ala 
65                  70                  75                  80  


Lys Ala Arg Gly Gln Asn Val Thr Ile Phe Tyr Val Asn Arg Leu Gly 
                85                  90                  95      


Tyr Tyr Pro Trp Tyr Thr Ser Gln Gly Val Pro Ile Asn Gly Gly Leu 
            100                 105                 110         


Pro Gln Asn Ile Ser Leu Gln Val His Leu Glu Lys Ala Asp Gln Asp 
        115                 120                 125             


Ile Asn Tyr Tyr Ile Pro Ala Glu Asp Phe Ser Gly Leu Ala Val Ile 
    130                 135                 140                 


Asp Trp Glu Tyr Trp Arg Pro Gln Trp Ala Arg Asn Trp Asn Ser Lys 
145                 150                 155                 160 


Asp Val Tyr Arg Gln Lys Ser Arg Lys Leu Ile Ser Asp Met Gly Lys 
                165                 170                 175     


Asn Val Ser Ala Thr Asp Ile Glu Tyr Leu Ala Lys Val Thr Phe Glu 
            180                 185                 190         


Glu Ser Ala Lys Ala Phe Met Lys Glu Thr Ile Lys Leu Gly Ile Lys 
        195                 200                 205             


Ser Arg Pro Lys Gly Leu Trp Gly Tyr Tyr Leu Tyr Pro Asp Cys His 
    210                 215                 220                 


Asn Tyr Asn Val Tyr Ala Pro Asn Tyr Ser Gly Ser Cys Pro Glu Asp 
225                 230                 235                 240 


Glu Val Leu Arg Asn Asn Glu Leu Ser Trp Leu Trp Asn Ser Ser Ala 
                245                 250                 255     


Ala Leu Tyr Pro Ser Ile Gly Val Trp Lys Ser Leu Gly Asp Ser Glu 
            260                 265                 270         


Asn Ile Leu Arg Phe Ser Lys Phe Arg Val His Glu Ser Met Arg Ile 
        275                 280                 285             


Ser Thr Met Thr Ser His Asp Tyr Ala Leu Pro Val Phe Val Tyr Thr 
    290                 295                 300                 


Arg Leu Gly Tyr Arg Asp Glu Pro Leu Phe Phe Leu Ser Lys Gln Asp 
305                 310                 315                 320 


Leu Val Ser Thr Ile Gly Glu Ser Ala Ala Leu Gly Ala Ala Gly Ile 
                325                 330                 335     


Val Ile Trp Gly Asp Met Asn Leu Thr Ala Ser Lys Ala Asn Cys Thr 
            340                 345                 350         


Lys Val Lys Gln Phe Val Ser Ser Asp Leu Gly Ser Tyr Ile Ala Asn 
        355                 360                 365             


Val Thr Arg Ala Ala Glu Val Cys Ser Leu His Leu Cys Arg Asn Asn 
    370                 375                 380                 


Gly Arg Cys Ile Arg Lys Met Trp Asn Ala Pro Ser Tyr Leu His Leu 
385                 390                 395                 400 


Asn Pro Ala Ser Tyr His Ile Glu Ala Ser Glu Asp Gly Glu Phe Thr 
                405                 410                 415     


Val Lys Gly Lys Ala Ser Asp Thr Asp Leu Ala Val Met Ala Asp Thr 
            420                 425                 430         


Phe Ser Cys His Cys Tyr Gln Gly Tyr Glu Gly Ala Asp Cys Arg Glu 
        435                 440                 445             


Ile Lys Thr Ala Asp Gly Cys Ser Gly Val Ser Pro Ser Pro Gly Ser 
    450                 455                 460                 


Leu Met Thr Leu Cys Leu Leu Leu Leu Ala Ser Tyr Arg Ser Ile Gln 
465                 470                 475                 480 


Leu 
    


<210>  5265
<211>  950
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYDIN__Homo_sapiens__NP_001185471

<400>  5265

Met Glu Ser Ala Gly Gly Phe Lys Leu Gly Met Glu Pro Leu Ser Gly 
1               5                   10                  15      


Gly Gly Val Cys Glu Lys Lys Lys Leu Leu Lys Met Thr Ser Arg Arg 
            20                  25                  30          


Leu Glu Glu Ser Met Gly Ala Val Gln Met Gly Leu Val Asn Met Phe 
        35                  40                  45              


Lys Gly Phe Gln Ser Lys Val Leu Pro Pro Leu Ser Pro Lys Val Val 
    50                  55                  60                  


Thr Glu Glu Glu Val Asn Arg Met Leu Thr Pro Ser Glu Phe Leu Lys 
65                  70                  75                  80  


Glu Met Ser Leu Thr Thr Glu Gln Arg Leu Ala Lys Thr Arg Leu Met 
                85                  90                  95      


Cys Arg Pro Gln Ile Ile Glu Leu Leu Asp Met Gly Glu Thr Thr His 
            100                 105                 110         


Gln Lys Phe Ser Gly Ile Asp Leu Asp Gln Ala Leu Phe Gln Pro Phe 
        115                 120                 125             


Pro Ser Glu Ile Ile Phe Gln Asn Tyr Thr Pro Cys Glu Val Tyr Glu 
    130                 135                 140                 


Val Pro Leu Ile Leu Arg Asn Asn Asp Lys Ile Pro Arg Leu Val Lys 
145                 150                 155                 160 


Val Val Glu Glu Ser Ser Pro Tyr Phe Lys Val Ile Ser Pro Lys Asp 
                165                 170                 175     


Ile Gly His Lys Val Ala Pro Gly Val Pro Ser Ile Phe Arg Ile Leu 
            180                 185                 190         


Phe Thr Pro Glu Glu Asn Lys Asp Tyr Ala His Thr Leu Thr Cys Val 
        195                 200                 205             


Thr Glu Arg Glu Lys Phe Ile Val Pro Ile Lys Ala Arg Gly Ala Arg 
    210                 215                 220                 


Ala Ile Leu Asp Phe Pro Asp Lys Leu Asn Phe Ser Thr Cys Pro Val 
225                 230                 235                 240 


Lys Tyr Ser Thr Gln Lys Ile Leu Leu Val Arg Asn Ile Gly Asn Lys 
                245                 250                 255     


Asn Ala Val Phe His Ile Lys Thr Cys Arg Pro Phe Ser Ile Glu Pro 
            260                 265                 270         


Ala Ile Gly Thr Leu Asn Val Gly Glu Ser Met Gln Leu Glu Val Glu 
        275                 280                 285             


Phe Glu Pro Gln Ser Val Gly Asp His Ser Gly Arg Leu Ile Val Cys 
    290                 295                 300                 


Tyr Asp Thr Gly Glu Lys Val Phe Val Ser Leu Tyr Gly Ala Ala Ile 
305                 310                 315                 320 


Asp Met Asn Ile Arg Leu Asp Lys Asn Ser Leu Thr Ile Glu Lys Thr 
                325                 330                 335     


Tyr Ile Ser Leu Ala Asn Gln Arg Thr Ile Thr Ile His Asn Arg Ser 
            340                 345                 350         


Asn Ile Ile Ala His Phe Leu Trp Lys Val Phe Ala Thr Gln Gln Glu 
        355                 360                 365             


Glu Asp Arg Glu Lys Tyr Arg Ala Cys Asp Asp Leu Ile Lys Glu Glu 
    370                 375                 380                 


Lys Asp Glu Thr Asp Glu Phe Phe Glu Glu Cys Ile Thr Asp Pro Leu 
385                 390                 395                 400 


Leu Arg Glu His Leu Ser Val Leu Ser Arg Thr Phe Ala Asn Gln Arg 
                405                 410                 415     


Arg Leu Val Gln Gly Asp Ser Lys Leu Phe Phe Asn Asn Val Phe Thr 
            420                 425                 430         


Val Glu Pro Leu Glu Gly Asp Val Trp Pro Asn Ser Ser Ala Glu Ile 
        435                 440                 445             


Thr Val Tyr Phe Asn Pro Leu Glu Ala Lys Leu Tyr Gln Gln Thr Ile 
    450                 455                 460                 


Tyr Cys Asp Ile Leu Gly Arg Glu Ile Arg Leu Pro Leu Arg Ile Lys 
465                 470                 475                 480 


Gly Glu Gly Met Gly Pro Lys Ile His Phe Asn Phe Glu Leu Leu Asp 
                485                 490                 495     


Ile Gly Lys Val Phe Thr Gly Ser Ala His Cys Tyr Glu Ala Ile Leu 
            500                 505                 510         


Tyr Asn Lys Gly Ser Ile Asp Ala Leu Phe Asn Met Thr Pro Pro Thr 
        515                 520                 525             


Ser Ala Leu Gly Ala Cys Phe Val Phe Ser Pro Lys Glu Gly Ile Ile 
    530                 535                 540                 


Glu Pro Ser Gly Val Gln Ala Ile Gln Ile Ser Phe Ser Ser Thr Ile 
545                 550                 555                 560 


Leu Gly Asn Phe Glu Glu Glu Phe Leu Val Asn Val Asn Gly Ser Pro 
                565                 570                 575     


Glu Pro Val Lys Leu Thr Ile Arg Gly Cys Val Ile Gly Pro Thr Phe 
            580                 585                 590         


His Phe Asn Val Pro Ala Leu His Phe Gly Asp Val Ser Phe Gly Phe 
        595                 600                 605             


Pro His Thr Leu Ile Cys Ser Leu Asn Asn Thr Ser Leu Ile Pro Met 
    610                 615                 620                 


Thr Tyr Lys Leu Arg Ile Pro Gly Asp Gly Leu Gly His Lys Ser Ile 
625                 630                 635                 640 


Ser Tyr Cys Glu Gln His Val Asp Tyr Lys Arg Pro Ser Trp Thr Lys 
                645                 650                 655     


Glu Glu Ile Ser Ser Met Lys Pro Lys Glu Phe Thr Ile Ser Pro Asp 
            660                 665                 670         


Cys Gly Thr Ile Arg Pro Gln Gly Phe Ala Ala Ile Arg Val Thr Leu 
        675                 680                 685             


Cys Ser Asn Thr Val Gln Lys Tyr Glu Leu Ala Leu Val Val Asp Val 
    690                 695                 700                 


Glu Gly Ile Gly Glu Glu Val Leu Ala Leu Leu Ile Thr Ala Arg Cys 
705                 710                 715                 720 


Val Val Pro Ala Leu His Leu Val Asn Thr Glu Val Asp Phe Gly His 
                725                 730                 735     


Cys Phe Leu Lys Tyr Pro Tyr Glu Lys Thr Leu Gln Leu Ala Asn Gln 
            740                 745                 750         


Asp Asp Leu Pro Gly Phe Tyr Glu Val Gln Pro Gln Val Cys Glu Glu 
        755                 760                 765             


Val Pro Thr Val Leu Phe Ser Ser Pro Thr Pro Ser Gly Val Ile Ser 
    770                 775                 780                 


Pro Ser Ser Thr Ile His Ile Pro Leu Val Leu Glu Thr Gln Val Thr 
785                 790                 795                 800 


Gly Glu His Arg Ser Thr Val Tyr Ile Ser Ile Phe Gly Ser Gln Asp 
                805                 810                 815     


Pro Pro Leu Val Cys His Leu Lys Ser Ala Gly Glu Gly Pro Val Ile 
            820                 825                 830         


Tyr Val His Pro Asn Gln Val Asp Phe Gly Asn Ile Tyr Val Leu Lys 
        835                 840                 845             


Asp Ser Ser Arg Ile Leu Asn Leu Cys Asn Gln Ser Phe Ile Pro Ala 
    850                 855                 860                 


Phe Phe Gln Ala His Met Ala His Lys Lys Ser Leu Trp Thr Ile Glu 
865                 870                 875                 880 


Pro Asn Glu Gly Met Val Pro Pro Glu Thr Asp Val Gln Leu Ala Leu 
                885                 890                 895     


Thr Ala Asn Leu Asn Asp Thr Leu Thr Phe Lys Asp Cys Val Ile Leu 
            900                 905                 910         


Asp Ile Glu Asn Ser Ser Thr Tyr Arg Ile Pro Val Gln Ala Ser Gly 
        915                 920                 925             


Thr Gly Ser Thr Ile Val Ser Asp Lys Pro Phe Ala Pro Glu Leu Asn 
    930                 935                 940                 


Leu Gly Ala His Phe Arg 
945                 950 


<210>  5266
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYKK__Homo_sapiens__NP_001013641

<400>  5266

Met Ser Ser Gly Asn Tyr Gln Gln Ser Glu Ala Leu Ser Lys Pro Thr 
1               5                   10                  15      


Phe Ser Glu Glu Gln Ala Ser Ala Leu Val Glu Ser Val Phe Gly Leu 
            20                  25                  30          


Lys Val Ser Lys Val Arg Pro Leu Pro Ser Tyr Asp Asp Gln Asn Phe 
        35                  40                  45              


His Val Tyr Val Ser Lys Thr Lys Asp Gly Pro Thr Glu Tyr Val Leu 
    50                  55                  60                  


Lys Ile Ser Asn Thr Lys Ala Ser Lys Asn Pro Asp Leu Ile Glu Val 
65                  70                  75                  80  


Gln Asn His Ile Ile Met Phe Leu Lys Ala Ala Gly Phe Pro Thr Ala 
                85                  90                  95      


Ser Val Cys His Thr Lys Gly Asp Asn Thr Ala Ser Leu Val Ser Val 
            100                 105                 110         


Asp Ser Gly Ser Glu Ile Lys Ser Tyr Leu Val Arg Leu Leu Thr Tyr 
        115                 120                 125             


Leu Pro Gly Arg Pro Ile Ala Glu Leu Pro Val Ser Pro Gln Leu Leu 
    130                 135                 140                 


Tyr Glu Ile Gly Lys Leu Ala Ala Lys Leu Asp Lys Thr Leu Gln Arg 
145                 150                 155                 160 


Phe His His Pro Lys Leu Ser Ser Leu His Arg Glu Asn Phe Ile Trp 
                165                 170                 175     


Asn Leu Lys Asn Val Pro Leu Leu Glu Lys Tyr Leu Tyr Ala Leu Gly 
            180                 185                 190         


Gln Asn Arg Asn Arg Glu Ile Val Glu His Val Ile His Leu Phe Lys 
        195                 200                 205             


Glu Glu Val Met Thr Lys Leu Ser His Phe Arg Glu Cys Ile Asn His 
    210                 215                 220                 


Gly Asp Leu Asn Asp His Asn Ile Leu Ile Glu Ser Ser Lys Ser Ala 
225                 230                 235                 240 


Ser Gly Asn Ala Glu Tyr Gln Val Ser Gly Ile Leu Asp Phe Gly Asp 
                245                 250                 255     


Met Ser Tyr Gly Tyr Tyr Val Phe Glu Val Ala Ile Thr Ile Met Tyr 
            260                 265                 270         


Met Met Ile Glu Ser Lys Ser Pro Ile Gln Val Gly Gly His Val Leu 
        275                 280                 285             


Ala Gly Phe Glu Ser Ile Thr Pro Leu Thr Ala Val Glu Lys Gly Ala 
    290                 295                 300                 


Leu Phe Leu Leu Val Cys Ser Arg Phe Cys Gln Ser Leu Val Met Ala 
305                 310                 315                 320 


Ala Tyr Ser Cys Gln Leu Tyr Pro Glu Asn Lys Asp Tyr Leu Met Val 
                325                 330                 335     


Thr Ala Lys Thr Gly Trp Lys His Leu Gln Gln Met Phe Asp Met Gly 
            340                 345                 350         


Gln Lys Ala Val Glu Glu Ile Trp Phe Glu Thr Ala Lys Ser Tyr Glu 
        355                 360                 365             


Ser Gly Ile Ser Met 
    370             


<210>  5267
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYLS1__Homo_sapiens__NP_659451

<400>  5267

Met Glu Glu Leu Leu Pro Asp Gly Gln Ile Trp Ala Asn Met Asp Pro 
1               5                   10                  15      


Glu Glu Arg Met Leu Ala Ala Ala Thr Ala Phe Thr His Ile Cys Ala 
            20                  25                  30          


Gly Gln Gly Glu Gly Asp Val Arg Arg Glu Ala Gln Ser Ile Gln Tyr 
        35                  40                  45              


Asp Pro Tyr Ser Lys Ala Ser Val Ala Pro Gly Lys Arg Pro Ala Leu 
    50                  55                  60                  


Pro Val Gln Leu Gln Tyr Pro His Val Glu Ser Asn Val Pro Ser Glu 
65                  70                  75                  80  


Thr Val Ser Glu Ala Ser Gln Arg Leu Arg Lys Pro Val Met Lys Arg 
                85                  90                  95      


Lys Val Leu Arg Arg Lys Pro Asp Gly Glu Val Leu Val Thr Asp Glu 
            100                 105                 110         


Ser Ile Ile Ser Glu Ser Glu Ser Gly Thr Glu Asn Asp Gln Asp Leu 
        115                 120                 125             


Trp Asp Leu Arg Gln Arg Leu Met Asn Val Gln Phe Gln Glu Asp Lys 
    130                 135                 140                 


Glu Ser Ser Phe Asp Val Ser Gln Lys Phe Asn Leu Pro His Glu Tyr 
145                 150                 155                 160 


Gln Gly Ile Ser Gln Asp Gln Leu Ile Cys Ser Leu Gln Arg Glu Gly 
                165                 170                 175     


Met Gly Ser Pro Ala Tyr Glu Gln Asp Leu Ile Val Ala Ser Arg Pro 
            180                 185                 190         


Lys Ser Phe Ile Leu Pro Lys Leu Asp Gln Leu Ser Arg Asn Arg Gly 
        195                 200                 205             


Lys Thr Asp Arg Val Ala Arg Tyr Phe Glu Tyr Lys Arg Asp Trp Asp 
    210                 215                 220                 


Ser Ile Arg Leu Pro Gly Glu Asp His Arg Lys Glu Leu Arg Trp Gly 
225                 230                 235                 240 


Val Arg Glu Gln Met Leu Cys Arg Ala Glu Pro Gln Ser Lys Pro Gln 
                245                 250                 255     


His Ile Tyr Val Pro Asn Asn Tyr Leu Val Pro Thr Glu Lys Lys Arg 
            260                 265                 270         


Ser Ala Leu Arg Trp Gly Val Arg Cys Asp Leu Ala Asn Gly Val Ile 
        275                 280                 285             


Pro Arg Lys Leu Pro Phe Pro Leu Ser Pro Ser 
    290                 295                 


<210>  5268
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYOU1__Homo_sapiens__NP_001124463

<400>  5268

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
        35                  40                  45              


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
    50                  55                  60                  


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
65                  70                  75                  80  


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
                85                  90                  95      


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
            100                 105                 110         


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
        115                 120                 125             


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
    130                 135                 140                 


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
145                 150                 155                 160 


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
                165                 170                 175     


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
            180                 185                 190         


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
        195                 200                 205             


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
    210                 215                 220                 


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
225                 230                 235                 240 


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
                245                 250                 255     


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
            260                 265                 270         


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
        275                 280                 285             


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
    290                 295                 300                 


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
305                 310                 315                 320 


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
                325                 330                 335     


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
            340                 345                 350         


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
        355                 360                 365             


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
    370                 375                 380                 


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
385                 390                 395                 400 


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
                405                 410                 415     


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
            420                 425                 430         


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
        435                 440                 445             


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
    450                 455                 460                 


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
465                 470                 475                 480 


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
                485                 490                 495     


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
            500                 505                 510         


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
        515                 520                 525             


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
    530                 535                 540                 


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
545                 550                 555                 560 


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
                565                 570                 575     


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
            580                 585                 590         


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
        595                 600                 605             


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
    610                 615                 620                 


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
625                 630                 635                 640 


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
                645                 650                 655     


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
            660                 665                 670         


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
        675                 680                 685             


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
    690                 695                 700                 


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
705                 710                 715                 720 


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
                725                 730                 735     


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
            740                 745                 750         


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
        755                 760                 765             


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
    770                 775                 780                 


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
785                 790                 795                 800 


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
                805                 810                 815     


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
            820                 825                 830         


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
        835                 840                 845             


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
    850                 855                 860                 


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
865                 870                 875                 880 


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
                885                 890                 895     


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
            900                 905                 910         


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
        915                 920                 925             


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
    930                 935                 940                 


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
945                 950                 955                 960 


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
                965                 970                 975     


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
            980                 985                 990         


Pro Leu Lys Asn Asp Glu Leu 
        995                 


<210>  5269
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYPM__Homo_sapiens__NP_036406

<400>  5269

Met Ser Glu Lys Lys Asn Cys Lys Asn Ser Ser Thr Asn Asn Asn Gln 
1               5                   10                  15      


Thr Gln Asp Pro Ser Arg Asn Glu Leu Gln Val Pro Arg Ser Phe Val 
            20                  25                  30          


Asp Arg Val Val Gln Asp Glu Arg Asp Val Gln Ser Gln Ser Ser Ser 
        35                  40                  45              


Thr Ile Asn Thr Leu Leu Thr Leu Leu Asp Cys Leu Ala Asp Tyr Ile 
    50                  55                  60                  


Met Glu Arg Val Gly Leu Glu Ala Ser Asn Asn Gly Ser Met Arg Asn 
65                  70                  75                  80  


Thr Ser Gln Asp Arg Glu Arg Glu Val Asp Asn Asn Arg Glu Pro His 
                85                  90                  95      


Ser Ala Glu Ser Asp Val Thr Arg Phe Leu Phe Asp Glu Met Pro Lys 
            100                 105                 110         


Ser Arg Lys Asn Asp 
        115         


<210>  5270
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IAPP__Homo_sapiens__NP_000406

<400>  5270

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys 
            20                  25                  30          


Arg Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
        35                  40                  45              


Leu Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn 
    50                  55                  60                  


Val Gly Ser Asn Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu Lys 
65                  70                  75                  80  


Arg Glu Pro Leu Asn Tyr Leu Pro Leu 
                85                  


<210>  5271
<211>  1012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IARS2__Homo_sapiens__NP_060530

<400>  5271

Met Arg Trp Gly Leu Arg Pro Arg Gly Pro Gly Ala Ala Ala Leu Ala 
1               5                   10                  15      


Thr Ala Arg Ser Leu Trp Gly Thr Pro Arg Leu Pro Cys Ser Pro Gly 
            20                  25                  30          


Trp Gln Gly Ala Thr Lys Arg Leu Leu Val Arg Ser Val Ser Gly Ala 
        35                  40                  45              


Ser Asn His Gln Pro Asn Ser Asn Ser Gly Arg Tyr Arg Asp Thr Val 
    50                  55                  60                  


Leu Leu Pro Gln Thr Ser Phe Pro Met Lys Leu Leu Gly Arg Gln Gln 
65                  70                  75                  80  


Pro Asp Thr Glu Leu Glu Ile Gln Gln Lys Cys Gly Phe Ser Glu Leu 
                85                  90                  95      


Tyr Ser Trp Gln Arg Glu Arg Lys Val Lys Thr Glu Phe Cys Leu His 
            100                 105                 110         


Asp Gly Pro Pro Tyr Ala Asn Gly Asp Pro His Val Gly His Ala Leu 
        115                 120                 125             


Asn Lys Ile Leu Lys Asp Ile Ala Asn Arg Phe His Met Met Asn Gly 
    130                 135                 140                 


Ser Lys Ile His Phe Val Pro Gly Trp Asp Cys His Gly Leu Pro Ile 
145                 150                 155                 160 


Glu Ile Lys Val Leu Ser Glu Leu Gly Arg Glu Ala Gln Asn Leu Ser 
                165                 170                 175     


Ala Met Glu Ile Arg Lys Lys Ala Arg Ser Phe Ala Lys Ala Ala Ile 
            180                 185                 190         


Glu Lys Gln Lys Ser Ala Phe Ile Arg Trp Gly Ile Met Ala Asp Trp 
        195                 200                 205             


Asn Asn Cys Tyr Tyr Thr Phe Asp Gly Lys Tyr Glu Ala Lys Gln Leu 
    210                 215                 220                 


Arg Thr Phe Tyr Gln Met Tyr Asp Lys Gly Leu Val Tyr Arg Ser Tyr 
225                 230                 235                 240 


Lys Pro Val Phe Trp Ser Pro Ser Ser Arg Thr Ala Leu Ala Glu Ala 
                245                 250                 255     


Glu Leu Glu Tyr Asn Pro Glu His Val Ser Arg Ser Ile Tyr Val Lys 
            260                 265                 270         


Phe Pro Leu Leu Lys Pro Ser Pro Lys Leu Ala Ser Leu Ile Asp Gly 
        275                 280                 285             


Ser Ser Pro Val Ser Ile Leu Val Trp Thr Thr Gln Pro Trp Thr Ile 
    290                 295                 300                 


Pro Ala Asn Glu Ala Val Cys Tyr Met Pro Glu Ser Lys Tyr Ala Val 
305                 310                 315                 320 


Val Lys Cys Ser Lys Ser Gly Asp Leu Tyr Val Leu Ala Ala Asp Lys 
                325                 330                 335     


Val Ala Ser Val Ala Ser Thr Leu Glu Thr Thr Phe Glu Thr Ile Ser 
            340                 345                 350         


Thr Leu Ser Gly Val Asp Leu Glu Asn Gly Thr Cys Ser His Pro Leu 
        355                 360                 365             


Ile Pro Asp Lys Ala Ser Pro Leu Leu Pro Ala Asn His Val Thr Met 
    370                 375                 380                 


Ala Lys Gly Thr Gly Leu Val His Thr Ala Pro Ala His Gly Met Glu 
385                 390                 395                 400 


Asp Tyr Gly Val Ala Ser Gln His Asn Leu Pro Met Asp Cys Leu Val 
                405                 410                 415     


Asp Glu Asp Gly Val Phe Thr Asp Val Ala Gly Pro Glu Leu Gln Asn 
            420                 425                 430         


Lys Ala Val Leu Glu Glu Gly Thr Asp Val Val Ile Lys Met Leu Gln 
        435                 440                 445             


Thr Ala Lys Asn Leu Leu Lys Glu Glu Lys Leu Val His Ser Tyr Pro 
    450                 455                 460                 


Tyr Asp Trp Arg Thr Lys Lys Pro Val Val Ile Arg Ala Ser Lys Gln 
465                 470                 475                 480 


Trp Phe Ile Asn Ile Thr Asp Ile Lys Thr Ala Ala Lys Glu Leu Leu 
                485                 490                 495     


Lys Lys Val Lys Phe Ile Pro Gly Ser Ala Leu Asn Gly Met Val Glu 
            500                 505                 510         


Met Met Asp Arg Arg Pro Tyr Trp Cys Ile Ser Arg Gln Arg Val Trp 
        515                 520                 525             


Gly Val Pro Ile Pro Val Phe His His Lys Thr Lys Asp Glu Tyr Leu 
    530                 535                 540                 


Ile Asn Ser Gln Thr Thr Glu His Ile Val Lys Leu Val Glu Gln His 
545                 550                 555                 560 


Gly Ser Asp Ile Trp Trp Thr Leu Pro Pro Glu Gln Leu Leu Pro Lys 
                565                 570                 575     


Glu Val Leu Ser Glu Val Gly Gly Pro Asp Ala Leu Glu Tyr Val Pro 
            580                 585                 590         


Gly Gln Asp Ile Leu Asp Ile Trp Phe Asp Ser Gly Thr Ser Trp Ser 
        595                 600                 605             


Tyr Val Leu Pro Gly Pro Asp Gln Arg Ala Asp Leu Tyr Leu Glu Gly 
    610                 615                 620                 


Lys Asp Gln Leu Gly Gly Trp Phe Gln Ser Ser Leu Leu Thr Ser Val 
625                 630                 635                 640 


Ala Ala Arg Lys Arg Ala Pro Tyr Lys Thr Val Ile Val His Gly Phe 
                645                 650                 655     


Thr Leu Gly Glu Lys Gly Glu Lys Met Ser Lys Ser Leu Gly Asn Val 
            660                 665                 670         


Ile His Pro Asp Val Val Val Asn Gly Gly Gln Asp Gln Ser Lys Glu 
        675                 680                 685             


Pro Pro Tyr Gly Ala Asp Val Leu Arg Trp Trp Val Ala Asp Ser Asn 
    690                 695                 700                 


Val Phe Thr Glu Val Ala Ile Gly Pro Ser Val Leu Asn Ala Ala Arg 
705                 710                 715                 720 


Asp Asp Ile Ser Lys Leu Arg Asn Thr Leu Arg Phe Leu Leu Gly Asn 
                725                 730                 735     


Val Ala Asp Phe Asn Pro Glu Thr Asp Ser Ile Pro Val Asn Asp Met 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Met Leu His Leu Leu Gln Asp Leu Ala Asn 
        755                 760                 765             


Lys Ile Thr Glu Leu Tyr Lys Gln Tyr Asp Phe Gly Lys Val Val Arg 
    770                 775                 780                 


Leu Leu Arg Thr Phe Tyr Thr Arg Glu Leu Ser Asn Phe Tyr Phe Ser 
785                 790                 795                 800 


Ile Ile Lys Asp Arg Leu Tyr Cys Glu Lys Glu Asn Asp Pro Lys Arg 
                805                 810                 815     


Arg Ser Cys Gln Thr Ala Leu Val Glu Ile Leu Asp Val Ile Val Arg 
            820                 825                 830         


Ser Phe Ala Pro Ile Leu Pro His Leu Ala Glu Glu Val Phe Gln His 
        835                 840                 845             


Ile Pro Tyr Ile Lys Glu Pro Lys Ser Val Phe Arg Thr Gly Trp Ile 
    850                 855                 860                 


Ser Thr Ser Ser Ile Trp Lys Lys Pro Gly Leu Glu Glu Ala Val Glu 
865                 870                 875                 880 


Ser Ala Cys Ala Met Arg Asp Ser Phe Leu Gly Ser Ile Pro Gly Lys 
                885                 890                 895     


Asn Ala Ala Glu Tyr Lys Val Ile Thr Val Ile Glu Pro Gly Leu Leu 
            900                 905                 910         


Phe Glu Ile Ile Glu Met Leu Gln Ser Glu Glu Thr Ser Ser Thr Ser 
        915                 920                 925             


Gln Leu Asn Glu Leu Met Met Ala Ser Glu Ser Thr Leu Leu Ala Gln 
    930                 935                 940                 


Glu Pro Arg Glu Met Thr Ala Asp Val Ile Glu Leu Lys Gly Lys Phe 
945                 950                 955                 960 


Leu Ile Asn Leu Glu Gly Gly Asp Ile Arg Glu Glu Ser Ser Tyr Lys 
                965                 970                 975     


Val Ile Val Met Pro Thr Thr Lys Glu Lys Cys Pro Arg Cys Trp Lys 
            980                 985                 990         


Tyr Thr Ala Glu Ser Ser Asp Thr  Leu Cys Pro Arg Cys  Ala Glu Val 
        995                 1000                 1005             


Val Ser  Gly Lys 
    1010         


<210>  5272
<211>  1262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IARS__Homo_sapiens__NP_038203

<400>  5272

Met Leu Gln Gln Val Pro Glu Asn Ile Asn Phe Pro Ala Glu Glu Glu 
1               5                   10                  15      


Lys Ile Leu Glu Phe Trp Thr Glu Phe Asn Cys Phe Gln Glu Cys Leu 
            20                  25                  30          


Lys Gln Ser Lys His Lys Pro Lys Phe Thr Phe Tyr Asp Gly Pro Pro 
        35                  40                  45              


Phe Ala Thr Gly Leu Pro His Tyr Gly His Ile Leu Ala Gly Thr Ile 
    50                  55                  60                  


Lys Asp Ile Val Thr Arg Tyr Ala His Gln Ser Gly Phe His Val Asp 
65                  70                  75                  80  


Arg Arg Phe Gly Trp Asp Cys His Gly Leu Pro Val Glu Tyr Glu Ile 
                85                  90                  95      


Asp Lys Thr Leu Gly Ile Arg Gly Pro Glu Asp Val Ala Lys Met Gly 
            100                 105                 110         


Ile Thr Glu Tyr Asn Asn Gln Cys Arg Ala Ile Val Met Arg Tyr Ser 
        115                 120                 125             


Ala Glu Trp Lys Ser Thr Val Ser Arg Leu Gly Arg Trp Ile Asp Phe 
    130                 135                 140                 


Asp Asn Asp Tyr Lys Thr Leu Tyr Pro Gln Phe Met Glu Ser Val Trp 
145                 150                 155                 160 


Trp Val Phe Lys Gln Leu Tyr Asp Lys Gly Leu Val Tyr Arg Gly Val 
                165                 170                 175     


Lys Val Met Pro Phe Ser Thr Ala Cys Asn Thr Pro Leu Ser Asn Phe 
            180                 185                 190         


Glu Ser His Gln Asn Tyr Lys Asp Val Gln Asp Pro Ser Val Phe Val 
        195                 200                 205             


Thr Phe Pro Leu Glu Glu Asp Glu Thr Val Ser Leu Val Ala Trp Thr 
    210                 215                 220                 


Thr Thr Pro Trp Thr Leu Pro Ser Asn Leu Ala Val Cys Val Asn Pro 
225                 230                 235                 240 


Glu Met Gln Tyr Val Lys Ile Lys Asp Val Ala Arg Gly Arg Leu Leu 
                245                 250                 255     


Ile Leu Met Glu Ala Arg Leu Ser Ala Leu Tyr Lys Leu Glu Ser Asp 
            260                 265                 270         


Tyr Glu Ile Leu Glu Arg Phe Pro Gly Ala Tyr Leu Lys Gly Lys Lys 
        275                 280                 285             


Tyr Arg Pro Leu Phe Asp Tyr Phe Leu Lys Cys Lys Glu Asn Gly Ala 
    290                 295                 300                 


Phe Thr Val Leu Val Asp Asn Tyr Val Lys Glu Glu Glu Gly Thr Gly 
305                 310                 315                 320 


Val Val His Gln Ala Pro Tyr Phe Gly Ala Glu Asp Tyr Arg Val Cys 
                325                 330                 335     


Met Asp Phe Asn Ile Ile Arg Lys Asp Ser Leu Pro Val Cys Pro Val 
            340                 345                 350         


Asp Ala Ser Gly Cys Phe Thr Thr Glu Val Thr Asp Phe Ala Gly Gln 
        355                 360                 365             


Tyr Val Lys Asp Ala Asp Lys Ser Ile Ile Arg Thr Leu Lys Glu Gln 
    370                 375                 380                 


Gly Arg Leu Leu Val Ala Thr Thr Phe Thr His Ser Tyr Pro Phe Cys 
385                 390                 395                 400 


Trp Arg Ser Asp Thr Pro Leu Ile Tyr Lys Ala Val Pro Ser Trp Phe 
                405                 410                 415     


Val Arg Val Glu Asn Met Val Asp Gln Leu Leu Arg Asn Asn Asp Leu 
            420                 425                 430         


Cys Tyr Trp Val Pro Glu Leu Val Arg Glu Lys Arg Phe Gly Asn Trp 
        435                 440                 445             


Leu Lys Asp Ala Arg Asp Trp Thr Ile Ser Arg Asn Arg Tyr Trp Gly 
    450                 455                 460                 


Thr Pro Ile Pro Leu Trp Val Ser Asp Asp Phe Glu Glu Val Val Cys 
465                 470                 475                 480 


Ile Gly Ser Val Ala Glu Leu Glu Glu Leu Ser Gly Ala Lys Ile Ser 
                485                 490                 495     


Asp Leu His Arg Glu Ser Val Asp His Leu Thr Ile Pro Ser Arg Cys 
            500                 505                 510         


Gly Lys Gly Ser Leu His Arg Ile Ser Glu Val Phe Asp Cys Trp Phe 
        515                 520                 525             


Glu Ser Gly Ser Met Pro Tyr Ala Gln Val His Tyr Pro Phe Glu Asn 
    530                 535                 540                 


Lys Arg Glu Phe Glu Asp Ala Phe Pro Ala Asp Phe Ile Ala Glu Gly 
545                 550                 555                 560 


Ile Asp Gln Thr Arg Gly Trp Phe Tyr Thr Leu Leu Val Leu Ala Thr 
                565                 570                 575     


Ala Leu Phe Gly Gln Pro Pro Phe Lys Asn Val Ile Val Asn Gly Leu 
            580                 585                 590         


Val Leu Ala Ser Asp Gly Gln Lys Met Ser Lys Arg Lys Lys Asn Tyr 
        595                 600                 605             


Pro Asp Pro Val Ser Ile Ile Gln Lys Tyr Gly Ala Asp Ala Leu Arg 
    610                 615                 620                 


Leu Tyr Leu Ile Asn Ser Pro Val Val Arg Ala Glu Asn Leu Arg Phe 
625                 630                 635                 640 


Lys Glu Glu Gly Val Arg Asp Val Leu Lys Asp Val Leu Leu Pro Trp 
                645                 650                 655     


Tyr Asn Ala Tyr Arg Phe Leu Ile Gln Asn Val Leu Arg Leu Gln Lys 
            660                 665                 670         


Glu Glu Glu Ile Glu Phe Leu Tyr Asn Glu Asn Thr Val Arg Glu Ser 
        675                 680                 685             


Pro Asn Ile Thr Asp Arg Trp Ile Leu Ser Phe Met Gln Ser Leu Ile 
    690                 695                 700                 


Gly Phe Phe Glu Thr Glu Met Ala Ala Tyr Arg Leu Tyr Thr Val Val 
705                 710                 715                 720 


Pro Arg Leu Val Lys Phe Val Asp Ile Leu Thr Asn Trp Tyr Val Arg 
                725                 730                 735     


Met Asn Arg Arg Arg Leu Lys Gly Glu Asn Gly Met Glu Asp Cys Val 
            740                 745                 750         


Met Ala Leu Glu Thr Leu Phe Ser Val Leu Leu Ser Leu Cys Arg Leu 
        755                 760                 765             


Met Ala Pro Tyr Thr Pro Phe Leu Thr Glu Leu Met Tyr Gln Asn Leu 
    770                 775                 780                 


Lys Val Leu Ile Asp Pro Val Ser Val Gln Asp Lys Asp Thr Leu Ser 
785                 790                 795                 800 


Ile His Tyr Leu Met Leu Pro Arg Val Arg Glu Glu Leu Ile Asp Lys 
                805                 810                 815     


Lys Thr Glu Ser Ala Val Ser Gln Met Gln Ser Val Ile Glu Leu Gly 
            820                 825                 830         


Arg Val Ile Arg Asp Arg Lys Thr Ile Pro Ile Lys Tyr Pro Leu Lys 
        835                 840                 845             


Glu Ile Val Val Ile His Gln Asp Pro Glu Ala Leu Lys Asp Ile Lys 
    850                 855                 860                 


Ser Leu Glu Lys Tyr Ile Ile Glu Glu Leu Asn Val Arg Lys Val Thr 
865                 870                 875                 880 


Leu Ser Thr Asp Lys Asn Lys Tyr Gly Ile Arg Leu Arg Ala Glu Pro 
                885                 890                 895     


Asp His Met Val Leu Gly Lys Arg Leu Lys Gly Ala Phe Lys Ala Val 
            900                 905                 910         


Met Thr Ser Ile Lys Gln Leu Ser Ser Glu Glu Leu Glu Gln Phe Gln 
        915                 920                 925             


Lys Thr Gly Thr Ile Val Val Glu Gly His Glu Leu His Asp Glu Asp 
    930                 935                 940                 


Ile Arg Leu Met Tyr Thr Phe Asp Gln Ala Thr Gly Gly Thr Ala Gln 
945                 950                 955                 960 


Phe Glu Ala His Ser Asp Ala Gln Ala Leu Val Leu Leu Asp Val Thr 
                965                 970                 975     


Pro Asp Gln Ser Met Val Asp Glu Gly Met Ala Arg Glu Val Ile Asn 
            980                 985                 990         


Arg Ile Gln Lys Leu Arg Lys Lys  Cys Asn Leu Val Pro  Thr Asp Glu 
        995                 1000                 1005             


Ile Thr  Val Tyr Tyr Lys Ala  Lys Ser Glu Gly Thr  Tyr Leu Asn 
    1010                 1015                 1020             


Ser Val  Ile Glu Ser His Thr  Glu Phe Ile Phe Thr  Thr Ile Lys 
    1025                 1030                 1035             


Ala Pro  Leu Lys Pro Tyr Pro  Val Ser Pro Ser Asp  Lys Val Leu 
    1040                 1045                 1050             


Ile Gln  Glu Lys Thr Gln Leu  Lys Gly Ser Glu Leu  Glu Ile Thr 
    1055                 1060                 1065             


Leu Thr  Arg Gly Ser Ser Leu  Pro Gly Pro Ala Cys  Ala Tyr Val 
    1070                 1075                 1080             


Asn Leu  Asn Ile Cys Ala Asn  Gly Ser Glu Gln Gly  Gly Val Leu 
    1085                 1090                 1095             


Leu Leu  Glu Asn Pro Lys Gly  Asp Asn Arg Leu Asp  Leu Leu Lys 
    1100                 1105                 1110             


Leu Lys  Ser Val Val Thr Ser  Ile Phe Gly Val Lys  Asn Thr Glu 
    1115                 1120                 1125             


Leu Ala  Val Phe His Asp Glu  Thr Glu Ile Gln Asn  Gln Thr Asp 
    1130                 1135                 1140             


Leu Leu  Ser Leu Ser Gly Lys  Thr Leu Cys Val Thr  Ala Gly Ser 
    1145                 1150                 1155             


Ala Pro  Ser Leu Ile Asn Ser  Ser Ser Thr Leu Leu  Cys Gln Tyr 
    1160                 1165                 1170             


Ile Asn  Leu Gln Leu Leu Asn  Ala Lys Pro Gln Glu  Cys Leu Met 
    1175                 1180                 1185             


Gly Thr  Val Gly Thr Leu Leu  Leu Glu Asn Pro Leu  Gly Gln Asn 
    1190                 1195                 1200             


Gly Leu  Thr His Gln Gly Leu  Leu Tyr Glu Ala Ala  Lys Val Phe 
    1205                 1210                 1215             


Gly Leu  Arg Ser Arg Lys Leu  Lys Leu Phe Leu Asn  Glu Thr Gln 
    1220                 1225                 1230             


Thr Gln  Glu Ile Thr Glu Asp  Ile Pro Val Lys Thr  Leu Asn Met 
    1235                 1240                 1245             


Lys Thr  Val Tyr Val Ser Val  Leu Pro Thr Thr Ala  Asp Phe 
    1250                 1255                 1260         


<210>  5273
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IBA57__Homo_sapiens__NP_001010867

<400>  5273

Met Ala Thr Ala Ala Leu Leu Arg Gly Ala Thr Pro Gly Arg Gly Gly 
1               5                   10                  15      


Pro Val Trp Arg Trp Arg Leu Arg Ala Ala Pro Arg Cys Arg Leu Ala 
            20                  25                  30          


His Ser Ser Cys Ser Pro Gly Gly Asp Pro Thr Ala Gly Ala Ala Trp 
        35                  40                  45              


Ala Cys Phe Arg Leu Asp Gly Arg Thr Leu Leu Arg Val Arg Gly Pro 
    50                  55                  60                  


Asp Ala Ala Pro Phe Leu Leu Gly Leu Leu Thr Asn Glu Leu Pro Leu 
65                  70                  75                  80  


Pro Ser Pro Ala Ala Ala Gly Ala Pro Pro Ala Ala Arg Ala Gly Tyr 
                85                  90                  95      


Ala His Phe Leu Asn Val Gln Gly Arg Thr Leu Tyr Asp Val Ile Leu 
            100                 105                 110         


Tyr Gly Leu Gln Glu His Ser Glu Val Ser Gly Phe Leu Leu Glu Cys 
        115                 120                 125             


Asp Ser Ser Val Gln Gly Ala Leu Gln Lys His Leu Ala Leu Tyr Arg 
    130                 135                 140                 


Ile Arg Arg Lys Val Thr Val Glu Pro His Pro Glu Leu Arg Val Trp 
145                 150                 155                 160 


Ala Val Leu Pro Ser Ser Pro Glu Ala Cys Gly Ala Ala Ser Leu Gln 
                165                 170                 175     


Glu Arg Ala Gly Ala Ala Ala Ile Leu Ile Arg Asp Pro Arg Thr Ala 
            180                 185                 190         


Arg Met Gly Trp Arg Leu Leu Thr Gln Asp Glu Gly Pro Ala Leu Val 
        195                 200                 205             


Pro Gly Gly Arg Leu Gly Asp Leu Trp Asp Tyr His Gln His Arg Tyr 
    210                 215                 220                 


Leu Gln Gly Val Pro Glu Gly Val Arg Asp Leu Pro Pro Gly Val Ala 
225                 230                 235                 240 


Leu Pro Leu Glu Ser Asn Leu Ala Phe Met Asn Gly Val Ser Phe Thr 
                245                 250                 255     


Lys Gly Cys Tyr Ile Gly Gln Glu Leu Thr Ala Arg Thr His His Met 
            260                 265                 270         


Gly Val Ile Arg Lys Arg Leu Phe Pro Val Arg Phe Leu Asp Pro Leu 
        275                 280                 285             


Pro Thr Ser Gly Ile Thr Pro Gly Ala Thr Val Leu Thr Ala Ser Gly 
    290                 295                 300                 


Gln Thr Val Gly Lys Phe Arg Ala Gly Gln Gly Asn Val Gly Leu Ala 
305                 310                 315                 320 


Leu Leu Trp Ser Glu Lys Ile Lys Gly Pro Leu His Ile Arg Ala Ser 
                325                 330                 335     


Glu Gly Ala Gln Val Ala Leu Ala Ala Ser Val Pro Asp Trp Trp Pro 
            340                 345                 350         


Thr Val Ser Lys 
        355     


<210>  5274
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IBSP__Homo_sapiens__NP_004958

<400>  5274

Met Lys Thr Ala Leu Ile Leu Leu Ser Ile Leu Gly Met Ala Cys Ala 
1               5                   10                  15      


Phe Ser Met Lys Asn Leu His Arg Arg Val Lys Ile Glu Asp Ser Glu 
            20                  25                  30          


Glu Asn Gly Val Phe Lys Tyr Arg Pro Arg Tyr Tyr Leu Tyr Lys His 
        35                  40                  45              


Ala Tyr Phe Tyr Pro His Leu Lys Arg Phe Pro Val Gln Gly Ser Ser 
    50                  55                  60                  


Asp Ser Ser Glu Glu Asn Gly Asp Asp Ser Ser Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Thr Ser Asn Glu Gly Glu Asn Asn Glu Glu Ser Asn Glu 
                85                  90                  95      


Asp Glu Asp Ser Glu Ala Glu Asn Thr Thr Leu Ser Ala Thr Thr Leu 
            100                 105                 110         


Gly Tyr Gly Glu Asp Ala Thr Pro Gly Thr Gly Tyr Thr Gly Leu Ala 
        115                 120                 125             


Ala Ile Gln Leu Pro Lys Lys Ala Gly Asp Ile Thr Asn Lys Ala Thr 
    130                 135                 140                 


Lys Glu Lys Glu Ser Asp Glu Glu Glu Glu Glu Glu Glu Glu Gly Asn 
145                 150                 155                 160 


Glu Asn Glu Glu Ser Glu Ala Glu Val Asp Glu Asn Glu Gln Gly Ile 
                165                 170                 175     


Asn Gly Thr Ser Thr Asn Ser Thr Glu Ala Glu Asn Gly Asn Gly Ser 
            180                 185                 190         


Ser Gly Gly Asp Asn Gly Glu Glu Gly Glu Glu Glu Ser Val Thr Gly 
        195                 200                 205             


Ala Asn Ala Glu Asp Thr Thr Glu Thr Gly Arg Gln Gly Lys Gly Thr 
    210                 215                 220                 


Ser Lys Thr Thr Thr Ser Pro Asn Gly Gly Phe Glu Pro Thr Thr Pro 
225                 230                 235                 240 


Pro Gln Val Tyr Arg Thr Thr Ser Pro Pro Phe Gly Lys Thr Thr Thr 
                245                 250                 255     


Val Glu Tyr Glu Gly Glu Tyr Glu Tyr Thr Gly Ala Asn Glu Tyr Asp 
            260                 265                 270         


Asn Gly Tyr Glu Ile Tyr Glu Ser Glu Asn Gly Glu Pro Arg Gly Asp 
        275                 280                 285             


Asn Tyr Arg Ala Tyr Glu Asp Glu Tyr Ser Tyr Phe Lys Gly Gln Gly 
    290                 295                 300                 


Tyr Asp Gly Tyr Asp Gly Gln Asn Tyr Tyr His His Gln 
305                 310                 315         


<210>  5275
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IBTK__Homo_sapiens__NP_056340

<400>  5275

Met Ser Ser Pro Met Pro Asp Cys Thr Ser Lys Cys Arg Ser Leu Lys 
1               5                   10                  15      


His Ala Leu Asp Val Leu Ser Val Val Thr Lys Gly Ser Glu Asn Gln 
            20                  25                  30          


Ile Lys Ala Phe Leu Ser Ser His Cys Tyr Asn Ala Ala Thr Ile Lys 
        35                  40                  45              


Asp Val Phe Gly Arg Asn Ala Leu His Leu Val Ser Ser Cys Gly Lys 
    50                  55                  60                  


Lys Gly Val Leu Asp Trp Leu Ile Gln Lys Gly Val Asp Leu Leu Val 
65                  70                  75                  80  


Lys Asp Lys Glu Ser Gly Trp Thr Ala Leu His Arg Ser Ile Phe Tyr 
                85                  90                  95      


Gly His Ile Asp Cys Val Trp Ser Leu Leu Lys His Gly Val Ser Leu 
            100                 105                 110         


Tyr Ile Gln Asp Lys Glu Gly Leu Ser Ala Leu Asp Leu Val Met Lys 
        115                 120                 125             


Asp Arg Pro Thr His Val Val Phe Lys Asn Thr Asp Pro Thr Asp Val 
    130                 135                 140                 


Tyr Thr Trp Gly Asp Asn Thr Asn Phe Thr Leu Gly His Gly Ser Gln 
145                 150                 155                 160 


Asn Ser Lys His His Pro Glu Leu Val Asp Leu Phe Ser Arg Ser Gly 
                165                 170                 175     


Ile Tyr Ile Lys Gln Val Val Leu Cys Lys Phe His Ser Val Phe Leu 
            180                 185                 190         


Ser Gln Lys Gly Gln Val Tyr Thr Cys Gly His Gly Pro Gly Gly Arg 
        195                 200                 205             


Leu Gly His Gly Asp Glu Gln Thr Cys Leu Val Pro Arg Leu Val Glu 
    210                 215                 220                 


Gly Leu Asn Gly His Asn Cys Ser Gln Val Ala Ala Ala Lys Asp His 
225                 230                 235                 240 


Thr Val Val Leu Thr Glu Asp Gly Cys Val Tyr Thr Phe Gly Leu Asn 
                245                 250                 255     


Ile Phe His Gln Leu Gly Ile Ile Pro Pro Pro Ser Ser Cys Asn Val 
            260                 265                 270         


Pro Arg Gln Ile Gln Ala Lys Tyr Leu Lys Gly Arg Thr Ile Ile Gly 
        275                 280                 285             


Val Ala Ala Gly Arg Phe His Thr Val Leu Trp Thr Arg Glu Ala Val 
    290                 295                 300                 


Tyr Thr Met Gly Leu Asn Gly Gly Gln Leu Gly Cys Leu Leu Asp Pro 
305                 310                 315                 320 


Asn Gly Glu Lys Cys Val Thr Ala Pro Arg Gln Val Ser Ala Leu His 
                325                 330                 335     


His Lys Asp Ile Ala Leu Ser Leu Val Ala Ala Ser Asp Gly Ala Thr 
            340                 345                 350         


Val Cys Val Thr Thr Arg Gly Asp Ile Tyr Leu Leu Ala Asp Tyr Gln 
        355                 360                 365             


Cys Lys Lys Met Ala Ser Lys Gln Leu Asn Leu Lys Lys Val Leu Val 
    370                 375                 380                 


Ser Gly Gly His Met Glu Tyr Lys Val Asp Pro Glu His Leu Lys Glu 
385                 390                 395                 400 


Asn Gly Gly Gln Lys Ile Cys Ile Leu Ala Met Asp Gly Ala Gly Arg 
                405                 410                 415     


Val Phe Cys Trp Arg Ser Val Asn Ser Ser Leu Lys Gln Cys Arg Trp 
            420                 425                 430         


Ala Tyr Pro Arg Gln Val Phe Ile Ser Asp Ile Ala Leu Asn Arg Asn 
        435                 440                 445             


Glu Ile Leu Phe Val Thr Gln Asp Gly Glu Gly Phe Arg Gly Arg Trp 
    450                 455                 460                 


Phe Glu Glu Lys Arg Lys Ser Ser Glu Lys Lys Glu Ile Leu Ser Asn 
465                 470                 475                 480 


Leu His Asn Ser Ser Ser Asp Val Ser Tyr Val Ser Asp Ile Asn Ser 
                485                 490                 495     


Val Tyr Glu Arg Ile Arg Leu Glu Lys Leu Thr Phe Ala His Arg Ala 
            500                 505                 510         


Val Ser Val Ser Thr Asp Pro Ser Gly Cys Asn Phe Ala Ile Leu Gln 
        515                 520                 525             


Ser Asp Pro Lys Thr Ser Leu Tyr Glu Ile Pro Ala Val Ser Ser Ser 
    530                 535                 540                 


Ser Phe Phe Glu Glu Phe Gly Lys Leu Leu Arg Glu Ala Asp Glu Met 
545                 550                 555                 560 


Asp Ser Ile His Asp Val Thr Phe Gln Val Gly Asn Arg Leu Phe Pro 
                565                 570                 575     


Ala His Lys Tyr Ile Leu Ala Val His Ser Asp Phe Phe Gln Lys Leu 
            580                 585                 590         


Phe Leu Ser Asp Gly Asn Thr Ser Glu Phe Thr Asp Ile Tyr Gln Lys 
        595                 600                 605             


Asp Glu Asp Ser Ala Gly Cys His Leu Phe Val Val Glu Lys Val His 
    610                 615                 620                 


Pro Asp Met Phe Glu Tyr Leu Leu Gln Phe Ile Tyr Thr Asp Thr Cys 
625                 630                 635                 640 


Asp Phe Leu Thr His Gly Phe Lys Pro Arg Ile His Leu Asn Lys Asn 
                645                 650                 655     


Pro Glu Glu Tyr Gln Gly Thr Leu Asn Ser His Leu Asn Lys Val Asn 
            660                 665                 670         


Phe His Glu Asp Asp Asn Gln Lys Ser Ala Phe Glu Val Tyr Lys Ser 
        675                 680                 685             


Asn Gln Ala Gln Thr Val Ser Glu Arg Gln Lys Ser Lys Pro Lys Ser 
    690                 695                 700                 


Cys Lys Lys Gly Lys Asn Ile Arg Glu Asp Asp Pro Val Arg Met Leu 
705                 710                 715                 720 


Gln Thr Val Ala Lys Lys Phe Asp Phe Ser Asn Leu Ser Ser Arg Leu 
                725                 730                 735     


Asp Gly Val Arg Phe Glu Asn Glu Lys Ile Asn Val Ile Ala Lys Asn 
            740                 745                 750         


Thr Gly Asn Lys Leu Lys Leu Ser Gln Lys Lys Cys Ser Phe Leu Cys 
        755                 760                 765             


Asp Val Thr Met Lys Ser Val Asp Gly Lys Glu Phe Pro Cys His Lys 
    770                 775                 780                 


Cys Val Leu Cys Ala Arg Leu Glu Tyr Phe His Ser Met Leu Ser Ser 
785                 790                 795                 800 


Ser Trp Ile Glu Ala Ser Ser Cys Ala Ala Leu Glu Met Pro Ile His 
                805                 810                 815     


Ser Asp Ile Leu Lys Val Ile Leu Asp Tyr Leu Tyr Thr Asp Glu Ala 
            820                 825                 830         


Val Val Ile Lys Glu Ser Gln Asn Val Asp Phe Ile Cys Ser Val Leu 
        835                 840                 845             


Val Val Ala Asp Gln Leu Leu Ile Thr Arg Leu Lys Glu Ile Cys Glu 
    850                 855                 860                 


Val Ala Leu Thr Glu Lys Leu Thr Leu Lys Asn Ala Ala Met Leu Leu 
865                 870                 875                 880 


Glu Phe Ala Ala Met Tyr Ser Ala Lys Gln Leu Lys Leu Ser Cys Leu 
                885                 890                 895     


Gln Phe Ile Gly Leu Asn Met Ala Ala Leu Leu Glu Ala Arg Ser Leu 
            900                 905                 910         


Asp Val Leu Ser Asp Gly Val Leu Lys Asp Leu Ser Glu Phe Tyr Arg 
        915                 920                 925             


Lys Met Ile Pro Ala Met Asp Arg Arg Val Ile Thr Pro Tyr Gln Asp 
    930                 935                 940                 


Gly Pro Asp Ile Ser Tyr Leu Glu Val Glu Asp Gly Asp Ile Phe Leu 
945                 950                 955                 960 


Lys Glu Glu Ile Asn Met Glu Gln Asn His Ser Glu Thr Met Phe Lys 
                965                 970                 975     


Lys Ala Lys Thr Lys Ala Lys Lys Lys Pro Arg Lys Arg Ser Asp Ser 
            980                 985                 990         


Ser Gly Gly Tyr Asn Leu Ser Asp  Ile Ile Gln Ser Pro  Ser Ser Thr 
        995                 1000                 1005             


Gly Leu  Leu Lys Ser Gly Lys  Thr Asn Ser Val Glu  Ser Leu Pro 
    1010                 1015                 1020             


Glu Leu  Leu Thr Ser Asp Ser  Glu Gly Ser Tyr Ala  Gly Val Gly 
    1025                 1030                 1035             


Ser Pro  Arg Asp Leu Gln Ser  Pro Asp Phe Thr Thr  Gly Phe His 
    1040                 1045                 1050             


Ser Asp  Lys Ile Glu Ala Lys  Val Lys Pro Tyr Val  Asn Gly Thr 
    1055                 1060                 1065             


Ser Pro  Val Tyr Ser Arg Glu  Asp Leu Lys Pro Trp  Glu Lys Ser 
    1070                 1075                 1080             


Pro Ile  Leu Lys Ile Ser Ala  Pro Gln Pro Ile Pro  Ser Asn Arg 
    1085                 1090                 1095             


Ile Asp  Thr Thr Ser Ser Ala  Ser Trp Val Ala Gly  Ser Phe Ser 
    1100                 1105                 1110             


Pro Val  Ser Pro Pro Val Val  Asp Leu Arg Thr Ile  Met Glu Ile 
    1115                 1120                 1125             


Glu Glu  Ser Arg Gln Lys Cys  Gly Ala Thr Pro Lys  Ser His Leu 
    1130                 1135                 1140             


Gly Lys  Thr Val Ser His Gly  Val Lys Leu Ser Gln  Lys Gln Arg 
    1145                 1150                 1155             


Lys Met  Ile Ala Leu Thr Thr  Lys Glu Asn Asn Ser  Gly Met Asn 
    1160                 1165                 1170             


Ser Met  Glu Thr Val Leu Phe  Thr Pro Ser Lys Ala  Pro Lys Pro 
    1175                 1180                 1185             


Val Asn  Ala Trp Ala Ser Ser  Leu His Ser Val Ser  Ser Lys Ser 
    1190                 1195                 1200             


Phe Arg  Asp Phe Leu Leu Glu  Glu Lys Lys Ser Val  Thr Ser His 
    1205                 1210                 1215             


Ser Ser  Gly Asp His Val Lys  Lys Val Ser Phe Lys  Gly Ile Glu 
    1220                 1225                 1230             


Asn Ser  Gln Ala Pro Lys Ile  Val Arg Cys Ser Thr  His Gly Thr 
    1235                 1240                 1245             


Pro Gly  Pro Glu Gly Asn His  Ile Ser Asp Leu Pro  Leu Leu Asp 
    1250                 1255                 1260             


Ser Pro  Asn Pro Trp Leu Ser  Ser Ser Val Thr Ala  Pro Ser Met 
    1265                 1270                 1275             


Val Ala  Pro Val Thr Phe Ala  Ser Ile Val Glu Glu  Glu Leu Gln 
    1280                 1285                 1290             


Gln Glu  Ala Ala Leu Ile Arg  Ser Arg Glu Lys Pro  Leu Ala Leu 
    1295                 1300                 1305             


Ile Gln  Ile Glu Glu His Ala  Ile Gln Asp Leu Leu  Val Phe Tyr 
    1310                 1315                 1320             


Glu Ala  Phe Gly Asn Pro Glu  Glu Phe Val Ile Val  Glu Arg Thr 
    1325                 1330                 1335             


Pro Gln  Gly Pro Leu Ala Val  Pro Met Trp Asn Lys  His Gly Cys 
    1340                 1345                 1350             


<210>  5276
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICA1__Homo_sapiens__NP_001263407

<400>  5276

Met Ser Gly His Lys Cys Tyr Pro Trp Asp Leu Gln Asp Arg Tyr Ala 
1               5                   10                  15      


Gln Asp Lys Ser Val Val Asn Lys Met Gln Gln Lys Tyr Trp Glu Thr 
            20                  25                  30          


Lys Gln Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu His Val 
        35                  40                  45              


Val Ala Ser Asp Ala Asp Leu Asp Ala Lys Leu Glu Leu Phe His Ser 
    50                  55                  60                  


Ile Gln Arg Thr Cys Leu Asp Leu Ser Lys Ala Ile Val Leu Tyr Gln 
65                  70                  75                  80  


Lys Arg Ile Cys Phe Leu Ser Gln Glu Glu Asn Glu Leu Gly Lys Phe 
                85                  90                  95      


Leu Arg Ser Gln Gly Phe Gln Asp Lys Thr Arg Ala Gly Lys Met Met 
            100                 105                 110         


Gln Ala Thr Gly Lys Ala Leu Cys Phe Ser Ser Gln Gln Arg Leu Ala 
        115                 120                 125             


Leu Arg Asn Pro Leu Cys Arg Phe His Gln Glu Val Glu Thr Phe Arg 
    130                 135                 140                 


His Arg Ala Ile Ser Asp Thr Trp Leu Thr Val Asn Arg Met Glu Gln 
145                 150                 155                 160 


Cys Arg Thr Glu Tyr Arg Gly Ala Leu Leu Trp Met Lys Asp Val Ser 
                165                 170                 175     


Gln Glu Leu Asp Pro Asp Leu Tyr Lys Gln Met Glu Lys Phe Arg Lys 
            180                 185                 190         


Val Gln Thr Gln Val Arg Leu Ala Lys Lys Asn Phe Asp Lys Leu Lys 
        195                 200                 205             


Met Asp Val Cys Gln Lys Val Asp Leu Leu Gly Ala Ser Arg Cys Asn 
    210                 215                 220                 


Leu Leu Ser His Met Leu Ala Thr Tyr Gln Thr Thr Leu Leu His Phe 
225                 230                 235                 240 


Trp Glu Lys Thr Ser His Thr Met Ala Ala Ile His Glu Ser Phe Lys 
                245                 250                 255     


Gly Tyr Gln Pro Tyr Glu Phe Thr Thr Leu Lys Ser Leu Gln Asp Pro 
            260                 265                 270         


Met Lys Lys Leu Val Glu Lys Glu Glu Lys Lys Lys Ile Asn Gln Gln 
        275                 280                 285             


Glu Ser Thr Asp Ala Ala Val Gln Glu Pro Ser Gln Leu Ile Ser Leu 
    290                 295                 300                 


Glu Glu Glu Asn Gln Arg Lys Glu Ser Ser Ser Phe Lys Thr Glu Asp 
305                 310                 315                 320 


Gly Lys Ser Ile Leu Ser Ala Leu Asp Lys Gly Ser Thr His Thr Ala 
                325                 330                 335     


Cys Ser Gly Pro Ile Asp Glu Leu Leu Asp Met Lys Ser Glu Glu Gly 
            340                 345                 350         


Ala Cys Leu Gly Pro Val Ala Gly Thr Pro Glu Pro Glu Gly Ala Asp 
        355                 360                 365             


Lys Asp Asp Leu Leu Leu Leu Ser Glu Ile Phe Asn Ala Ser Ser Leu 
    370                 375                 380                 


Glu Glu Gly Glu Phe Ser Lys Glu Trp Ala Ala Val Phe Gly Asp Gly 
385                 390                 395                 400 


Gln Val Lys Glu Pro Val Pro Thr Met Ala Leu Gly Glu Pro Asp Pro 
                405                 410                 415     


Lys Ala Gln Thr Gly Ser Gly Phe Leu Pro Ser Gln Leu Leu Asp Gln 
            420                 425                 430         


Asn Met Lys Asp Leu Gln Ala Ser Leu Gln Glu Pro Ala Lys Ala Ala 
        435                 440                 445             


Ser Asp Leu Thr Ala Trp Phe Ser Leu Phe Ala Asp Leu Asp Pro Leu 
    450                 455                 460                 


Ser Asn Pro Asp Ala Val Gly Lys Thr Asp Lys Glu His Glu Leu Leu 
465                 470                 475                 480 


Asn Ala 
        


<210>  5277
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICAM1__Homo_sapiens__NP_000192

<400>  5277

Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210>  5278
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICAM2__Homo_sapiens__NP_001093259

<400>  5278

Met Ser Ser Phe Gly Tyr Arg Thr Leu Thr Val Ala Leu Phe Thr Leu 
1               5                   10                  15      


Ile Cys Cys Pro Gly Ser Asp Glu Lys Val Phe Glu Val His Val Arg 
            20                  25                  30          


Pro Lys Lys Leu Ala Val Glu Pro Lys Gly Ser Leu Glu Val Asn Cys 
        35                  40                  45              


Ser Thr Thr Cys Asn Gln Pro Glu Val Gly Gly Leu Glu Thr Ser Leu 
    50                  55                  60                  


Asp Lys Ile Leu Leu Asp Glu Gln Ala Gln Trp Lys His Tyr Leu Val 
65                  70                  75                  80  


Ser Asn Ile Ser His Asp Thr Val Leu Gln Cys His Phe Thr Cys Ser 
                85                  90                  95      


Gly Lys Gln Glu Ser Met Asn Ser Asn Val Ser Val Tyr Gln Pro Pro 
            100                 105                 110         


Arg Gln Val Ile Leu Thr Leu Gln Pro Thr Leu Val Ala Val Gly Lys 
        115                 120                 125             


Ser Phe Thr Ile Glu Cys Arg Val Pro Thr Val Glu Pro Leu Asp Ser 
    130                 135                 140                 


Leu Thr Leu Phe Leu Phe Arg Gly Asn Glu Thr Leu His Tyr Glu Thr 
145                 150                 155                 160 


Phe Gly Lys Ala Ala Pro Ala Pro Gln Glu Ala Thr Ala Thr Phe Asn 
                165                 170                 175     


Ser Thr Ala Asp Arg Glu Asp Gly His Arg Asn Phe Ser Cys Leu Ala 
            180                 185                 190         


Val Leu Asp Leu Met Ser Arg Gly Gly Asn Ile Phe His Lys His Ser 
        195                 200                 205             


Ala Pro Lys Met Leu Glu Ile Tyr Glu Pro Val Ser Asp Ser Gln Met 
    210                 215                 220                 


Val Ile Ile Val Thr Val Val Ser Val Leu Leu Ser Leu Phe Val Thr 
225                 230                 235                 240 


Ser Val Leu Leu Cys Phe Ile Phe Gly Gln His Leu Arg Gln Gln Arg 
                245                 250                 255     


Met Gly Thr Tyr Gly Val Arg Ala Ala Trp Arg Arg Leu Pro Gln Ala 
            260                 265                 270         


Phe Arg Pro 
        275 


<210>  5279
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICAM3__Homo_sapiens__NP_002153

<400>  5279

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg 
    210                 215                 220                 


Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp 
225                 230                 235                 240 


Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu 
                245                 250                 255     


Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp 
            260                 265                 270         


Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly 
        275                 280                 285             


Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu 
    290                 295                 300                 


Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn 
305                 310                 315                 320 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
                325                 330                 335     


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
            340                 345                 350         


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
        355                 360                 365             


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
    370                 375                 380                 


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
385                 390                 395                 400 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
                405                 410                 415     


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
            420                 425                 430         


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
        435                 440                 445             


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
    450                 455                 460                 


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
                485                 490                 495     


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
            500                 505                 510         


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
        515                 520                 525             


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
    530                 535                 540                 


Arg Ala Glu 
545         


<210>  5280
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICAM4__Homo_sapiens__NP_001034221

<400>  5280

Met Gly Ser Leu Phe Pro Leu Ser Leu Leu Phe Phe Leu Ala Ala Ala 
1               5                   10                  15      


Tyr Pro Gly Val Gly Ser Ala Leu Gly Arg Arg Thr Lys Arg Ala Gln 
            20                  25                  30          


Ser Pro Lys Gly Ser Pro Leu Ala Pro Ser Gly Thr Ser Val Pro Phe 
        35                  40                  45              


Trp Val Arg Met Ser Pro Glu Phe Val Ala Val Gln Pro Gly Lys Ser 
    50                  55                  60                  


Val Gln Leu Asn Cys Ser Asn Ser Cys Pro Gln Pro Gln Asn Ser Ser 
65                  70                  75                  80  


Leu Arg Thr Pro Leu Arg Gln Gly Lys Thr Leu Arg Gly Pro Gly Trp 
                85                  90                  95      


Val Ser Tyr Gln Leu Leu Asp Val Arg Ala Trp Ser Ser Leu Ala His 
            100                 105                 110         


Cys Leu Val Thr Cys Ala Gly Lys Thr Arg Trp Ala Thr Ser Arg Ile 
        115                 120                 125             


Thr Ala Tyr Ser Val Pro Gly Gly Leu Leu Gly Gly Asp Pro Glu Ala 
    130                 135                 140                 


Trp Lys Pro Gly His Leu Phe Arg Lys Pro Gly Ala Leu His Arg Pro 
145                 150                 155                 160 


Gly Ser Gly Gln Arg Asp Leu Asp Leu Arg Val Cys Cys Trp Thr Pro 
                165                 170                 175     


Arg Leu Leu Ala Ala Arg Asp Leu Pro Arg Ala Pro Gln Ser Arg Arg 
            180                 185                 190         


Pro Gly Gly Pro Gln Gln Leu Gly Thr His Tyr Thr Asp Ala Arg Leu 
        195                 200                 205             


Glu Pro Arg Ala His Ser Phe Gly Leu Arg Phe His Arg Cys Pro Cys 
    210                 215                 220                 


Arg Asp Pro Pro His Cys Gly Arg Cys Val Pro Met Gln Val Pro Ser 
225                 230                 235                 240 


Tyr Glu Val Pro Gly Val Lys Gly Asp Val Leu Cys Arg Leu Ser Glu 
                245                 250                 255     


Lys Lys Arg Asn Met Lys Gln Ser Gly Glu Met Ala Ile His Gly Gly 
            260                 265                 270         


<210>  5281
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICAM5__Homo_sapiens__NP_003250

<400>  5281

Met Pro Gly Pro Ser Pro Gly Leu Arg Arg Ala Leu Leu Gly Leu Trp 
1               5                   10                  15      


Ala Ala Leu Gly Leu Gly Leu Phe Gly Leu Ser Ala Val Ser Gln Glu 
            20                  25                  30          


Pro Phe Trp Ala Asp Leu Gln Pro Arg Val Ala Phe Val Glu Arg Gly 
        35                  40                  45              


Gly Ser Leu Trp Leu Asn Cys Ser Thr Asn Cys Pro Arg Pro Glu Arg 
    50                  55                  60                  


Gly Gly Leu Glu Thr Ser Leu Arg Arg Asn Gly Thr Gln Arg Gly Leu 
65                  70                  75                  80  


Arg Trp Leu Ala Arg Gln Leu Val Asp Ile Arg Glu Pro Glu Thr Gln 
                85                  90                  95      


Pro Val Cys Phe Phe Arg Cys Ala Arg Arg Thr Leu Gln Ala Arg Gly 
            100                 105                 110         


Leu Ile Arg Thr Phe Gln Arg Pro Asp Arg Val Glu Leu Met Pro Leu 
        115                 120                 125             


Pro Pro Trp Gln Pro Val Gly Glu Asn Phe Thr Leu Ser Cys Arg Val 
    130                 135                 140                 


Pro Gly Ala Gly Pro Arg Ala Ser Leu Thr Leu Thr Leu Leu Arg Gly 
145                 150                 155                 160 


Ala Gln Glu Leu Ile Arg Arg Ser Phe Ala Gly Glu Pro Pro Arg Ala 
                165                 170                 175     


Arg Gly Ala Val Leu Thr Ala Thr Val Leu Ala Arg Arg Glu Asp His 
            180                 185                 190         


Gly Ala Asn Phe Ser Cys Arg Ala Glu Leu Asp Leu Arg Pro His Gly 
        195                 200                 205             


Leu Gly Leu Phe Glu Asn Ser Ser Ala Pro Arg Glu Leu Arg Thr Phe 
    210                 215                 220                 


Ser Leu Ser Pro Asp Ala Pro Arg Leu Ala Ala Pro Arg Leu Leu Glu 
225                 230                 235                 240 


Val Gly Ser Glu Arg Pro Val Ser Cys Thr Leu Asp Gly Leu Phe Pro 
                245                 250                 255     


Ala Ser Glu Ala Arg Val Tyr Leu Ala Leu Gly Asp Gln Asn Leu Ser 
            260                 265                 270         


Pro Asp Val Thr Leu Glu Gly Asp Ala Phe Val Ala Thr Ala Thr Ala 
        275                 280                 285             


Thr Ala Ser Ala Glu Gln Glu Gly Ala Arg Gln Leu Val Cys Asn Val 
    290                 295                 300                 


Thr Leu Gly Gly Glu Asn Arg Glu Thr Arg Glu Asn Val Thr Ile Tyr 
305                 310                 315                 320 


Ser Phe Pro Ala Pro Leu Leu Thr Leu Ser Glu Pro Ser Val Ser Glu 
                325                 330                 335     


Gly Gln Met Val Thr Val Thr Cys Ala Ala Gly Ala Gln Ala Leu Val 
            340                 345                 350         


Thr Leu Glu Gly Val Pro Ala Ala Val Pro Gly Gln Pro Ala Gln Leu 
        355                 360                 365             


Gln Leu Asn Ala Thr Glu Asn Asp Asp Arg Arg Ser Phe Phe Cys Asp 
    370                 375                 380                 


Ala Thr Leu Asp Val Asp Gly Glu Thr Leu Ile Lys Asn Arg Ser Ala 
385                 390                 395                 400 


Glu Leu Arg Val Leu Tyr Ala Pro Arg Leu Asp Asp Ser Asp Cys Pro 
                405                 410                 415     


Arg Ser Trp Thr Trp Pro Glu Gly Pro Glu Gln Thr Leu Arg Cys Glu 
            420                 425                 430         


Ala Arg Gly Asn Pro Glu Pro Ser Val His Cys Ala Arg Ser Asp Gly 
        435                 440                 445             


Gly Ala Val Leu Ala Leu Gly Leu Leu Gly Pro Val Thr Arg Ala Leu 
    450                 455                 460                 


Ser Gly Thr Tyr Arg Cys Lys Ala Ala Asn Asp Gln Gly Glu Ala Val 
465                 470                 475                 480 


Lys Asp Val Thr Leu Thr Val Glu Tyr Ala Pro Ala Leu Asp Ser Val 
                485                 490                 495     


Gly Cys Pro Glu Arg Ile Thr Trp Leu Glu Gly Thr Glu Ala Ser Leu 
            500                 505                 510         


Ser Cys Val Ala His Gly Val Pro Pro Pro Asp Val Ile Cys Val Arg 
        515                 520                 525             


Ser Gly Glu Leu Gly Ala Val Ile Glu Gly Leu Leu Arg Val Ala Arg 
    530                 535                 540                 


Glu His Ala Gly Thr Tyr Arg Cys Glu Ala Thr Asn Pro Arg Gly Ser 
545                 550                 555                 560 


Ala Ala Lys Asn Val Ala Val Thr Val Glu Tyr Gly Pro Arg Phe Glu 
                565                 570                 575     


Glu Pro Ser Cys Pro Ser Asn Trp Thr Trp Val Glu Gly Ser Gly Arg 
            580                 585                 590         


Leu Phe Ser Cys Glu Val Asp Gly Lys Pro Gln Pro Ser Val Lys Cys 
        595                 600                 605             


Val Gly Ser Gly Gly Ala Thr Glu Gly Val Leu Leu Pro Leu Ala Pro 
    610                 615                 620                 


Pro Asp Pro Ser Pro Arg Ala Pro Arg Ile Pro Arg Val Leu Ala Pro 
625                 630                 635                 640 


Gly Ile Tyr Val Cys Asn Ala Thr Asn Arg His Gly Ser Val Ala Lys 
                645                 650                 655     


Thr Val Val Val Ser Ala Glu Ser Pro Pro Glu Met Asp Glu Ser Thr 
            660                 665                 670         


Cys Pro Ser His Gln Thr Trp Leu Glu Gly Ala Glu Ala Ser Ala Leu 
        675                 680                 685             


Ala Cys Ala Ala Arg Gly Arg Pro Ser Pro Gly Val Arg Cys Ser Arg 
    690                 695                 700                 


Glu Gly Ile Pro Trp Pro Glu Gln Gln Arg Val Ser Arg Glu Asp Ala 
705                 710                 715                 720 


Gly Thr Tyr His Cys Val Ala Thr Asn Ala His Gly Thr Asp Ser Arg 
                725                 730                 735     


Thr Val Thr Val Gly Val Glu Tyr Arg Pro Val Val Ala Glu Leu Ala 
            740                 745                 750         


Ala Ser Pro Pro Gly Gly Val Arg Pro Gly Gly Asn Phe Thr Leu Thr 
        755                 760                 765             


Cys Arg Ala Glu Ala Trp Pro Pro Ala Gln Ile Ser Trp Arg Ala Pro 
    770                 775                 780                 


Pro Gly Ala Leu Asn Ile Gly Leu Ser Ser Asn Asn Ser Thr Leu Ser 
785                 790                 795                 800 


Val Ala Gly Ala Met Gly Ser His Gly Gly Glu Tyr Glu Cys Ala Ala 
                805                 810                 815     


Thr Asn Ala His Gly Arg His Ala Arg Arg Ile Thr Val Arg Val Ala 
            820                 825                 830         


Gly Pro Trp Leu Trp Val Ala Val Gly Gly Ala Ala Gly Gly Ala Ala 
        835                 840                 845             


Leu Leu Ala Ala Gly Ala Gly Leu Ala Phe Tyr Val Gln Ser Thr Ala 
    850                 855                 860                 


Cys Lys Lys Gly Glu Tyr Asn Val Gln Glu Ala Glu Ser Ser Gly Glu 
865                 870                 875                 880 


Ala Val Cys Leu Asn Gly Ala Gly Gly Gly Ala Gly Gly Ala Ala Gly 
                885                 890                 895     


Ala Glu Gly Gly Pro Glu Ala Ala Gly Gly Ala Ala Glu Ser Pro Ala 
            900                 905                 910         


Glu Gly Glu Val Phe Ala Ile Gln Leu Thr Ser Ala 
        915                 920                 


<210>  5282
<211>  2266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICE1__Homo_sapiens__NP_056140

<400>  5282

Met Met Pro Gly Glu Thr His Ser Ala Ala Pro Gly Thr Ala Ala Asp 
1               5                   10                  15      


Leu Ser Arg Cys Gln Gly Cys Ala Ser Leu Gln Gln Asn Leu Asn Glu 
            20                  25                  30          


Tyr Val Glu Ala Leu Ile Thr Leu Lys Gln Lys Ile Ile Asn Thr Asp 
        35                  40                  45              


Asn Leu Leu Thr Glu Tyr Gln Lys Lys Cys Asp Glu Leu Gln Phe Ala 
    50                  55                  60                  


Arg Arg Glu Asn Ser Asn Leu His His Gln Val Glu Glu Met Leu Gln 
65                  70                  75                  80  


Lys Ile Ser Pro Leu Gln Lys Cys Gln Glu Glu Leu Gly Ser Leu Lys 
                85                  90                  95      


Ala Glu Leu Glu Glu Lys Lys Ser Ser Leu Lys Leu Tyr Gln Asp Thr 
            100                 105                 110         


His Gln Glu Tyr Ala Arg Val Lys Glu Glu Cys Leu Lys Ser Asp Ala 
        115                 120                 125             


Gln Lys Lys Lys Leu Glu Ala Lys Val Lys Lys Leu Gln Glu Ala Ala 
    130                 135                 140                 


Val Lys Gln Thr Gln Asp Phe Lys Gln Leu Arg Asn Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Lys Lys Thr Gln Glu Arg Leu Asp Glu Phe Ser 
                165                 170                 175     


Lys Gln Lys Asn Glu Lys Glu Leu Arg His Ile Gly Thr Gln Ile Ser 
            180                 185                 190         


Ser Asp Ser Tyr Gly Ser Ile Asp Lys Arg Lys Val Lys Leu Leu Leu 
        195                 200                 205             


Lys Glu Leu Trp Leu Cys Val Asn Thr Thr His Arg Leu Pro Gly Glu 
    210                 215                 220                 


Gly Ser Arg Cys Val Pro Glu Lys Pro Ala Lys Ala Ile Thr Ser Ser 
225                 230                 235                 240 


Arg Val Pro Gly Glu Asp Gly Thr Leu Pro Pro Thr Gln Gly Ser Pro 
                245                 250                 255     


Leu Arg Thr Ser Asn Val Gln Thr Cys Leu Thr Lys Leu Ser Met Glu 
            260                 265                 270         


Ile Lys Glu Asp Phe Leu Cys Gln Asn Val Glu Lys Gln Ser Ser Ser 
        275                 280                 285             


Gly Thr Asn Cys Ser Ser Asp His Val Phe Asn Glu Asn Gly Asn Leu 
    290                 295                 300                 


Glu Val Leu Val Gln Ser His Arg Asp Gly Gly Ser Thr Glu Phe Val 
305                 310                 315                 320 


Asp His Asp His Phe Phe Asp Glu Asp Leu Gln Ala Ala Ile Asp Phe 
                325                 330                 335     


Phe Lys Leu Pro Pro Pro Leu Leu Ser Pro Val Pro Ser Pro Pro Pro 
            340                 345                 350         


Met Ser Ser Pro His Pro Gly Ser Leu Pro Ser Ser Phe Ala Pro Glu 
        355                 360                 365             


Thr Tyr Phe Gly Glu Tyr Thr Asp Ser Ser Asp Asn Asp Ser Val Gln 
    370                 375                 380                 


Leu Arg Asn Ser Ala Glu Cys Val Ser Glu Asp Asp Thr Thr Glu Ser 
385                 390                 395                 400 


Gln Asn Tyr Phe Gly Ser Leu Arg Lys Asn Lys Gly Ser Gly Thr Trp 
                405                 410                 415     


Glu Glu Lys Pro Lys Ser His Glu Ala Ile Gln Ala Leu Asn Thr Trp 
            420                 425                 430         


Glu Val Asn Lys Val Thr Thr Ser Gly Leu Glu Thr Phe Thr Ala Thr 
        435                 440                 445             


Leu Arg Glu Ser Ser Ala Thr His Ser Leu Val Gly Glu Lys His Trp 
    450                 455                 460                 


Thr Thr Ala Ser Arg Ser Met Ser Asp Arg Lys Arg Asp Ile Leu His 
465                 470                 475                 480 


Glu Thr Lys Thr Gln Met Glu Val Arg Glu Met Asp Lys Ser Val Gln 
                485                 490                 495     


Thr Glu Lys Thr Ile His Lys Leu Thr Arg Gly Leu Cys Ile Glu Arg 
            500                 505                 510         


Leu Ser Ala Ser Pro Ala Gln Glu Lys Glu Ala Ala Pro Gly Lys Ser 
        515                 520                 525             


Glu Leu Cys Ser Ser Pro Leu Gly Lys Arg Pro Leu Asn Glu Leu Met 
    530                 535                 540                 


Glu Ser Glu Gly Lys Thr Val Leu Ser Lys Met Met Gly Ser Pro Lys 
545                 550                 555                 560 


Ser Glu Phe Thr Lys Trp Thr Arg Ile Asn Glu Ile Thr Ser Glu Pro 
                565                 570                 575     


Asp Arg Ile Thr Val Ser Gly His Phe His Arg Leu Ser Arg Glu Leu 
            580                 585                 590         


Glu Lys Glu Lys Glu Asp Thr Gln Gly Phe Thr Leu Gly Glu Ser Pro 
        595                 600                 605             


Glu Ser Glu Asp Asp Asp Ser Gly Asp Gly Met Asp Val Ala Gly Leu 
    610                 615                 620                 


Asp Ile Glu Thr Ser Phe Ser Ser Ser Ser Thr Leu Val Ala Leu Ser 
625                 630                 635                 640 


Val Gly Ser Asn Pro Gln Ser Ser Ser Gly Leu Asp Cys Gly Asn Asp 
                645                 650                 655     


Thr Asp Ile Thr Thr Lys Val Phe Ser Thr Glu Pro His His Ser Glu 
            660                 665                 670         


His Lys Leu Gln Thr Lys Thr Leu Asn Thr Leu His Leu Gln Ser Glu 
        675                 680                 685             


Pro Pro Glu Cys Ser Ile Gly Gly Asn Asn Leu Glu Asn Ser Leu Cys 
    690                 695                 700                 


Ala Leu Ser Pro Glu Leu Gly Ala Ser Asn Phe Asn Asp Gln Lys Ser 
705                 710                 715                 720 


Ser Gly Ile Glu Tyr Thr Lys Val Val Lys Gly Leu Thr Lys Ile His 
                725                 730                 735     


Ser Leu Pro Arg Ser Val Phe Met Lys Ala Thr Lys Asp Gly Gln Cys 
            740                 745                 750         


Glu Ser Gln Asp Pro Arg Ile Glu Leu Thr Leu Asn Lys Pro Asp Phe 
        755                 760                 765             


Thr Ser Leu Ile Gly Ser Gln Ala Ala Leu Ile Lys Ser Gly Leu Gly 
    770                 775                 780                 


Phe Val Lys Ser Thr Ser Trp His His Ser Asp Leu Leu Arg Lys Gly 
785                 790                 795                 800 


Gly Glu Glu Ser Leu Arg Ala Lys Ser Glu His Glu Gln Lys Thr Ser 
                805                 810                 815     


His Gln Leu Gln Lys Ala Met Pro Phe Leu Gln Asn Arg Gly Pro Thr 
            820                 825                 830         


Pro Lys Pro Asp Leu Leu Arg Glu Asn Asn Asn Pro Val Glu Phe Lys 
        835                 840                 845             


Thr Thr Ala Ser Val Leu Pro Asn Gln Val Ser Val Ile Thr Lys Gln 
    850                 855                 860                 


Thr Arg Pro Glu Lys Val Gln Ser Ala Lys Leu Glu His Leu Arg Pro 
865                 870                 875                 880 


His Arg Val Glu Pro Thr Leu Val Thr Glu Asn Ser Gly Asn Lys Thr 
                885                 890                 895     


Gly Met Ser Thr Val Ala Lys Cys Asp Gly Glu Arg Asp Asp Thr Thr 
            900                 905                 910         


Gln Asn Ile Thr Glu Val Ala Ala Val Lys Ser Ile Ser Pro Glu Val 
        915                 920                 925             


Ser Ala Ser Arg Arg Lys Leu Asp Phe Asn Ser Pro Gly Gly Ser Ser 
    930                 935                 940                 


Pro Val Glu Asn Ser Asp Cys Ser Thr Asn Ser Arg Leu Ser Phe Ser 
945                 950                 955                 960 


Pro Glu Asn Ile Leu Ile Gln Asn Gln Asp Ile Val Arg Glu Ala Ala 
                965                 970                 975     


Val Gln Gly Asp Gly Gln Lys Gln Arg Gln Pro Gln Ala Thr Asp Leu 
            980                 985                 990         


Asp Ser Ser Gly Thr His Gly Ser  Glu Met Leu Pro Ala  Thr Glu Val 
        995                 1000                 1005             


Thr Val  Ser Gly Gly Phe Ser  Val Glu Glu Thr Ser  Cys Gly Asp 
    1010                 1015                 1020             


Thr Gly  Arg Ser Gly Gly Glu  Ala Leu Ala Val Ala  Asn Asp Ser 
    1025                 1030                 1035             


Thr Ser  Thr Pro Gln Asn Ala  Asn Gly Leu Trp Lys  Leu Lys Ser 
    1040                 1045                 1050             


Thr Thr  Pro Gly Gly Ala Leu  Pro Glu Cys Phe Gly  Thr Thr Asp 
    1055                 1060                 1065             


Thr Thr  Phe Ser Ser Ala Phe  Cys Arg Lys His Gly  Glu Thr Gln 
    1070                 1075                 1080             


Asp Thr  Ser Gln Ser Ser Leu  Pro Gly Thr Leu His  Cys Tyr Thr 
    1085                 1090                 1095             


Gly Ile  Arg Glu Gly Gly Asp  Asp Thr Glu Val Glu  Ser Glu Ala 
    1100                 1105                 1110             


Phe Ser  Cys Ser Glu Gly Ser  Glu Gln Gln Asp Ala  Pro Asp Asp 
    1115                 1120                 1125             


Ser Gln  Lys Asn Leu Gly Asp  Thr Asp Ala Ala Val  Ala Glu Val 
    1130                 1135                 1140             


Arg Pro  Ser Leu Glu Val Gly  Tyr Leu Thr Ser Ala  Leu Gln Asp 
    1145                 1150                 1155             


Phe Asn  Ile Ser Thr Phe Ser  Glu Leu Asp Arg Leu  Ser Thr Ser 
    1160                 1165                 1170             


Glu Val  Val Met Phe Leu Glu  Ser Cys Gln Leu Gly  Asp Tyr Ser 
    1175                 1180                 1185             


Ser Gly  Asp Ser Val Ser Glu  Cys Ser Ser Lys Gly  Thr Leu Ser 
    1190                 1195                 1200             


Lys Glu  Met Asn Lys Glu Leu  Lys Ala Ser Glu Ile  Gly Glu Lys 
    1205                 1210                 1215             


Tyr Arg  Lys Gln Pro Cys Glu  Glu Glu Thr Leu Gly  Thr Cys Glu 
    1220                 1225                 1230             


Glu Trp  Ile Glu Ser Glu Glu  Asp Asp Tyr Ser Leu  Lys Asn Thr 
    1235                 1240                 1245             


Ser Gln  Leu Thr Gln Cys Ser  Leu Glu Thr Leu Ser  Glu Val Leu 
    1250                 1255                 1260             


Thr Lys  Ile Arg Gln Glu Leu  Gln Thr Asn Ser Glu  Asp Cys Asn 
    1265                 1270                 1275             


Gly Lys  Asp Thr Gly Ser Leu  Leu Leu Leu Asn Val  Asn Asn Asn 
    1280                 1285                 1290             


Met Thr  Thr Glu Asn Leu Lys  Glu Lys Ser Pro Phe  Arg Glu Thr 
    1295                 1300                 1305             


Thr Gly  Ser Ser Ser His Ala  Ser Glu Pro Thr Pro  Gln Ala Ala 
    1310                 1315                 1320             


Ala Leu  Asp Thr Glu Gly Ser  Ser Pro Ile Ser Gly  Met Pro Gln 
    1325                 1330                 1335             


Asn Glu  Asn Pro Gln Ser Arg  Pro Glu Ala Arg Ser  Asp Ala Gly 
    1340                 1345                 1350             


Arg Gln  Thr Asp Gly Gly Glu  Glu Asp Leu Pro Glu  Pro Val Glu 
    1355                 1360                 1365             


Pro Ser  Ala Leu Cys Ser Asp  Ser Val Met Glu Pro  Ser Ile Glu 
    1370                 1375                 1380             


Gln Ser  Ser Asn Cys Glu Ala  Glu Thr Thr Phe Gln  Cys Gln Ile 
    1385                 1390                 1395             


Ala Thr  Val Thr Ser Glu Val  Ile Asn Val Leu Ile  Asn Lys Asp 
    1400                 1405                 1410             


Gln Asn  Leu Val Ile Glu Lys  Gly Asp Asn Trp Thr  Ile Ile Ser 
    1415                 1420                 1425             


Gly Val  Ala Val Leu Pro His  Val Asp Gln Val Thr  Leu Cys Asp 
    1430                 1435                 1440             


Ile Pro  Gly Asp Ile Pro Ile  Ser Gln Asp Gln Gly  Glu Leu Glu 
    1445                 1450                 1455             


Ala Gly  Cys Ile Pro Val Thr  Ser Ala Glu Lys Ser  Pro Glu Ala 
    1460                 1465                 1470             


Ser His  Thr Gly Pro Ala Phe  Gln Glu Ala Pro Cys  Gly Asn Asn 
    1475                 1480                 1485             


Leu Ser  Cys Pro Gln Glu Asp  Val Ser Ser Ser Gly  Gln Ser Thr 
    1490                 1495                 1500             


Asn Phe  Asp Lys Ser Arg Leu  Arg Asn Arg Pro Val  Lys Pro Ser 
    1505                 1510                 1515             


Ile Trp  Ile Ser Ser Gln Ile  Tyr Asp Gln Asn Phe  Glu Thr Gln 
    1520                 1525                 1530             


Ile Val  Ala Ser Asp His Thr  Tyr Tyr Asn Ser Lys  Leu Glu Pro 
    1535                 1540                 1545             


Ser Gly  Lys Asn Lys Asn Arg  Ser Lys Ile Ser Asn  Lys Asp Gln 
    1550                 1555                 1560             


Ser Asn  Lys Pro Val Lys Thr  Ser Ala Ser Ser Arg  Val Glu Thr 
    1565                 1570                 1575             


His Gln  Ser Glu Val Ala Gln  Ser Phe Ser Gly Glu  Lys Ala Asn 
    1580                 1585                 1590             


Thr Lys  Thr Gln Arg Ser Gln  Thr Gln Thr Ile Leu  Ala Asn Ala 
    1595                 1600                 1605             


Asp Thr  Ser Thr Pro Thr Asp  Cys Ser Pro Asp Thr  Leu Ser Lys 
    1610                 1615                 1620             


Ile Arg  Gln Glu Val Gly Pro  Pro Leu Pro Pro Leu  Leu Ala Pro 
    1625                 1630                 1635             


Leu Ile  Ala Thr Pro Pro Arg  Thr Ser Gln Pro Leu  Ser Pro Leu 
    1640                 1645                 1650             


Ile Ser  Ser Ser Ser Pro Ser  Ser Pro Ala Ser Pro  Val Gly Gln 
    1655                 1660                 1665             


Val Ser  Pro Phe Arg Glu Thr  Pro Val Pro Pro Ala  Met Ser Pro 
    1670                 1675                 1680             


Trp Pro  Glu Asp Pro Arg Arg  Ala Ser Pro Pro Asp  Pro Ser Pro 
    1685                 1690                 1695             


Ser Pro  Ser Ala Ala Ser Ala  Ser Glu Arg Val Val  Pro Ser Pro 
    1700                 1705                 1710             


Leu Gln  Phe Cys Ala Ala Thr  Pro Lys His Ala Leu  Pro Val Pro 
    1715                 1720                 1725             


Gly Arg  Leu Pro Pro Cys Ala  Ser Gly His Ala Ala  Val Gly Gly 
    1730                 1735                 1740             


Pro Gln  Glu Asn Ser Val Lys  Ile Leu Asp Thr Met  Tyr Pro Glu 
    1745                 1750                 1755             


Leu Ser  Ala Arg Ala Arg Thr  Leu Asn Ile Leu Lys  Gly Asn Ile 
    1760                 1765                 1770             


Gln Leu  Thr Arg Gly Pro Pro  Ala Asp Cys Lys Asn  Leu Pro Gly 
    1775                 1780                 1785             


Pro Ala  Ser Ala Met Ile Gly  Phe Lys Thr Ile Thr  Ser Ala Ala 
    1790                 1795                 1800             


Thr Ala  Phe Val Lys Thr Gly  Ser Ser Ser Gly Gly  Asp Cys Asn 
    1805                 1810                 1815             


Gln Asp  Lys Ser Arg Asp Leu  Gly Thr Gln Gln Asp  Ser Ser Gly 
    1820                 1825                 1830             


Lys Arg  Thr Leu Ser Thr Ser  Thr Leu Arg Ser Ala  Lys Arg Leu 
    1835                 1840                 1845             


Arg Leu  Asp Thr Gly Ser Pro  Glu Pro Glu Thr Arg  Gly Val Thr 
    1850                 1855                 1860             


Ala Glu  Gly Ile His Lys Asn  Leu Pro Gly Asn Leu  Pro Pro Ala 
    1865                 1870                 1875             


Glu Val  Ala Thr Thr Asn Glu  Glu Arg Ser Cys Ser  Ser Pro Ala 
    1880                 1885                 1890             


Val Ser  Ala Val Ser Gln Leu  Pro Leu Ser Pro Lys  Glu Thr Val 
    1895                 1900                 1905             


Glu Ser  His Asp Lys Ala Ile  Ala Asn Ala Leu Lys  Lys Ile Ala 
    1910                 1915                 1920             


Glu Phe  Ser Phe Asp Leu Leu  Pro Val Ile Arg Ser  His Val Tyr 
    1925                 1930                 1935             


Val Gly  Asn Ile Ser Lys Lys  Pro Val Met Arg Asp  Gln Glu Lys 
    1940                 1945                 1950             


Glu Val  Val Tyr Glu Phe Ser  Thr Thr Lys Lys His  Leu Ala Glu 
    1955                 1960                 1965             


Cys Leu  Leu His Ser Ile Leu  Ser Glu Leu Lys Ile  Gln Lys Ile 
    1970                 1975                 1980             


Ser Met  Asp His Asn Tyr Ile  His Ala Leu Cys Arg  Val Tyr Val 
    1985                 1990                 1995             


Gly Ile  Cys Arg Gln Leu Gly  Asp Leu Glu Arg Ala  Arg Leu Phe 
    2000                 2005                 2010             


Cys Tyr  Ser Leu Leu Lys Glu  Asp Phe Pro Glu Ser  Glu Lys Leu 
    2015                 2020                 2025             


Thr Leu  Phe Ile Ala Asn Met  Trp His Asp Ile Phe  Leu Ser Gln 
    2030                 2035                 2040             


Ser Val  Ile Asn Lys Ala Met  Gln Leu Val Ala Arg  Gln Arg Ala 
    2045                 2050                 2055             


Lys Gly  Glu Val Leu Asn Cys  Leu Arg Ala Phe Leu  Asn Trp Glu 
    2060                 2065                 2070             


Lys Asn  Ala Pro Val Asp Val  Gly Phe Met Val Ser  Lys Leu Leu 
    2075                 2080                 2085             


Leu Thr  Ile Gln Leu Cys Pro  Lys Thr Glu Phe Gln  Pro Ser Glu 
    2090                 2095                 2100             


Lys Phe  Gly Glu Asp Leu Ser  Asp Asn Thr Trp Glu  Tyr Ile Phe 
    2105                 2110                 2115             


Ala Ile  Asp Leu Leu Cys Cys  His Gln Lys Trp Ile  Trp Thr His 
    2120                 2125                 2130             


Asp Asn  Ile Ile Ser Lys Glu  Leu Trp Pro Val Met  Asp Lys Trp 
    2135                 2140                 2145             


Ile Lys  Tyr Arg Lys Gly His  Ala Asn Ile Ala Tyr  Thr Pro Asp 
    2150                 2155                 2160             


Ile Ile  Ile Ala Ser Ile Leu  Arg Leu Ile Gly Arg  Leu Gly Gln 
    2165                 2170                 2175             


Leu Gly  Leu Lys Glu Gly Phe  Pro Ser Ala Val Lys  Asn Ile Ser 
    2180                 2185                 2190             


Ser Val  Ile Gly Met Phe Ile  Gln His Ala His Asp  Glu Asp Ile 
    2195                 2200                 2205             


Pro Trp  Gly Ile Gln Leu Ala  Ala Val Tyr Ala Leu  Cys Asp Leu 
    2210                 2215                 2220             


Ser Pro  Ser Asn Pro Ala Glu  Ile Ser Lys Ile Leu  Glu Ala Trp 
    2225                 2230                 2235             


Arg Arg  Glu Ala Ser Lys Ser  Val Pro Ser Ala Ile  Val Ser Cys 
    2240                 2245                 2250             


Leu Glu  Glu Val Ser Ala Leu  Ser Thr Glu Glu Leu  Gly 
    2255                 2260                 2265     


<210>  5283
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICE2__Homo_sapiens__NP_001263314

<400>  5283

Met Ser Ser Lys Met Val Ile Ser Glu Pro Gly Leu Asn Trp Asp Ile 
1               5                   10                  15      


Ser Pro Lys Asn Gly Leu Lys Thr Phe Phe Ser Arg Glu Asn Tyr Lys 
            20                  25                  30          


Asp His Ser Met Ala Pro Ser Leu Lys Glu Leu Arg Val Leu Ser Asn 
        35                  40                  45              


Arg Arg Ile Gly Glu Asn Leu Asn Ala Ser Ala Ser Ser Val Glu Asn 
    50                  55                  60                  


Glu Pro Ala Val Ser Ser Ala Thr Gln Ala Lys Glu Lys Val Lys Thr 
65                  70                  75                  80  


Thr Ile Gly Met Val Leu Leu Pro Lys Pro Arg Val Pro Tyr Pro Arg 
                85                  90                  95      


Phe Ser Arg Phe Ser Gln Arg Glu Gln Arg Ser Tyr Val Asp Leu Leu 
            100                 105                 110         


Val Lys Tyr Ala Lys Ile Pro Ala Asn Ser Lys Ala Val Gly Ile Asn 
        115                 120                 125             


Lys Asn Asp Tyr Leu Gln Tyr Leu Asp Met Lys Lys His Val Asn Glu 
    130                 135                 140                 


Glu Val Thr Glu Phe Leu Lys Phe Leu Gln Asn Ser Ala Lys Lys Cys 
145                 150                 155                 160 


Ala Gln Asp Tyr Asn Met Leu Ser Asp Asp Ala Arg Leu Phe Thr Glu 
                165                 170                 175     


Lys Ile Leu Arg Ala Cys Ile Glu Gln Val Lys Lys Tyr Ser Glu Phe 
            180                 185                 190         


Tyr Thr Leu His Glu Val Thr Ser Leu Met Gly Phe Phe Pro Phe Arg 
        195                 200                 205             


Val Glu Met Gly Leu Lys Leu Glu Lys Thr Leu Leu Ala Leu Gly Ser 
    210                 215                 220                 


Val Lys Tyr Val Lys Thr Val Phe Pro Ser Met Pro Ile Lys Leu Gln 
225                 230                 235                 240 


Leu Ser Lys Asp Asp Ile Ala Thr Ile Glu Thr Ser Glu Gln Thr Ala 
                245                 250                 255     


Glu Ala Met His Tyr Asp Ile Ser Lys Asp Pro Asn Ala Glu Lys Leu 
            260                 265                 270         


Val Ser Arg Tyr His Pro Gln Ile Ala Leu Thr Ser Gln Ser Leu Phe 
        275                 280                 285             


Thr Leu Leu Asn Asn His Gly Pro Thr Tyr Lys Glu Gln Trp Glu Ile 
    290                 295                 300                 


Pro Val Cys Ile Gln Val Ile Pro Val Ala Gly Ser Lys Pro Val Lys 
305                 310                 315                 320 


Val Ile Tyr Ile Asn Ser Pro Leu Pro Gln Lys Lys Met Thr Met Arg 
                325                 330                 335     


Glu Arg Asn Gln Ile Phe His Glu Val Pro Leu Lys Phe Met Met Ser 
            340                 345                 350         


Lys Asn Thr Ser Val Pro Val Ser Ala Val Phe Met Asp Lys Pro Glu 
        355                 360                 365             


Glu Phe Ile Ser Glu Met Asp Val Cys Asn Ala Phe Phe Phe Pro 
    370                 375                 380             


<210>  5284
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICK__Homo_sapiens__NP_057597

<400>  5284

Met Asn Arg Tyr Thr Thr Ile Arg Gln Leu Gly Asp Gly Thr Tyr Gly 
1               5                   10                  15      


Ser Val Leu Leu Gly Arg Ser Ile Glu Ser Gly Glu Leu Ile Ala Ile 
            20                  25                  30          


Lys Lys Met Lys Arg Lys Phe Tyr Ser Trp Glu Glu Cys Met Asn Leu 
        35                  40                  45              


Arg Glu Val Lys Ser Leu Lys Lys Leu Asn His Ala Asn Val Val Lys 
    50                  55                  60                  


Leu Lys Glu Val Ile Arg Glu Asn Asp His Leu Tyr Phe Ile Phe Glu 
65                  70                  75                  80  


Tyr Met Lys Glu Asn Leu Tyr Gln Leu Ile Lys Glu Arg Asn Lys Leu 
                85                  90                  95      


Phe Pro Glu Ser Ala Ile Arg Asn Ile Met Tyr Gln Ile Leu Gln Gly 
            100                 105                 110         


Leu Ala Phe Ile His Lys His Gly Phe Phe His Arg Asp Leu Lys Pro 
        115                 120                 125             


Glu Asn Leu Leu Cys Met Gly Pro Glu Leu Val Lys Ile Ala Asp Phe 
    130                 135                 140                 


Gly Leu Ala Arg Glu Ile Arg Ser Lys Pro Pro Tyr Thr Asp Tyr Val 
145                 150                 155                 160 


Ser Thr Arg Trp Tyr Arg Ala Pro Glu Val Leu Leu Arg Ser Thr Asn 
                165                 170                 175     


Tyr Ser Ser Pro Ile Asp Val Trp Ala Val Gly Cys Ile Met Ala Glu 
            180                 185                 190         


Val Tyr Thr Leu Arg Pro Leu Phe Pro Gly Ala Ser Glu Ile Asp Thr 
        195                 200                 205             


Ile Phe Lys Ile Cys Gln Val Leu Gly Thr Pro Lys Lys Thr Asp Trp 
    210                 215                 220                 


Pro Glu Gly Tyr Gln Leu Ser Ser Ala Met Asn Phe Arg Trp Pro Gln 
225                 230                 235                 240 


Cys Val Pro Asn Asn Leu Lys Thr Leu Ile Pro Asn Ala Ser Ser Glu 
                245                 250                 255     


Ala Val Gln Leu Leu Arg Asp Met Leu Gln Trp Asp Pro Lys Lys Arg 
            260                 265                 270         


Pro Thr Ala Ser Gln Ala Leu Arg Tyr Pro Tyr Phe Gln Val Gly His 
        275                 280                 285             


Pro Leu Gly Ser Thr Thr Gln Asn Leu Gln Asp Ser Glu Lys Pro Gln 
    290                 295                 300                 


Lys Gly Ile Leu Glu Lys Ala Gly Pro Pro Pro Tyr Ile Lys Pro Val 
305                 310                 315                 320 


Pro Pro Ala Gln Pro Pro Ala Lys Pro His Thr Arg Ile Ser Ser Arg 
                325                 330                 335     


Gln His Gln Ala Ser Gln Pro Pro Leu His Leu Thr Tyr Pro Tyr Lys 
            340                 345                 350         


Ala Glu Val Ser Arg Thr Asp His Pro Ser His Leu Gln Glu Asp Lys 
        355                 360                 365             


Pro Ser Pro Leu Leu Phe Pro Ser Leu His Asn Lys His Pro Gln Ser 
    370                 375                 380                 


Lys Ile Thr Ala Gly Leu Glu His Lys Asn Gly Glu Ile Lys Pro Lys 
385                 390                 395                 400 


Ser Arg Arg Arg Trp Gly Leu Ile Ser Arg Ser Thr Lys Asp Ser Asp 
                405                 410                 415     


Asp Trp Ala Asp Leu Asp Asp Leu Asp Phe Ser Pro Ser Leu Ser Arg 
            420                 425                 430         


Ile Asp Leu Lys Asn Lys Lys Arg Gln Ser Asp Asp Thr Leu Cys Arg 
        435                 440                 445             


Phe Glu Ser Val Leu Asp Leu Lys Pro Ser Glu Pro Val Gly Thr Gly 
    450                 455                 460                 


Asn Ser Ala Pro Thr Gln Thr Ser Tyr Gln Arg Arg Asp Thr Pro Thr 
465                 470                 475                 480 


Leu Arg Ser Ala Ala Lys Gln His Tyr Leu Lys His Ser Arg Tyr Leu 
                485                 490                 495     


Pro Gly Ile Ser Ile Arg Asn Gly Ile Leu Ser Asn Pro Gly Lys Glu 
            500                 505                 510         


Phe Ile Pro Pro Asn Pro Trp Ser Ser Ser Gly Leu Ser Gly Lys Ser 
        515                 520                 525             


Ser Gly Thr Met Ser Val Ile Ser Lys Val Asn Ser Val Gly Ser Ser 
    530                 535                 540                 


Ser Thr Ser Ser Ser Gly Leu Thr Gly Asn Tyr Val Pro Ser Phe Leu 
545                 550                 555                 560 


Lys Lys Glu Ile Gly Ser Ala Met Gln Arg Val His Leu Ala Pro Ile 
                565                 570                 575     


Pro Asp Pro Ser Pro Gly Tyr Ser Ser Leu Lys Ala Met Arg Pro His 
            580                 585                 590         


Pro Gly Arg Pro Phe Phe His Thr Gln Pro Arg Ser Thr Pro Gly Leu 
        595                 600                 605             


Ile Pro Arg Pro Pro Ala Ala Gln Pro Val His Gly Arg Thr Asp Trp 
    610                 615                 620                 


Ala Ser Lys Tyr Ala Ser Arg Arg 
625                 630         


<210>  5285
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICMT__Homo_sapiens__XP_011539442

<400>  5285

Met Cys Ser Leu Ser Leu Phe His Tyr Ser Glu Tyr Leu Val Thr Ala 
1               5                   10                  15      


Val Asn Asn Pro Lys Ser Leu Ser Leu Asp Ser Phe Leu Leu Asn His 
            20                  25                  30          


Ser Leu Glu Tyr Thr Val Ala Ala Leu Ser Ser Trp Leu Glu Phe Thr 
        35                  40                  45              


Leu Glu Asn Ile Phe Trp Pro Glu Leu Lys Gln Ile Thr Trp Leu Ser 
    50                  55                  60                  


Val Thr Gly Leu Leu Met Val Val Phe Gly Glu Cys Leu Arg Lys Ala 
65                  70                  75                  80  


Ala Met Phe Thr Ala Gly Ser Asn Phe Asn His Val Val Gln Asn Glu 
                85                  90                  95      


Lys Ser Asp Thr His Thr Leu Val Thr Ser Gly Val Tyr Ala Trp Phe 
            100                 105                 110         


Arg His Pro Ser Tyr Val Gly Trp Phe Tyr Trp Ser Ile Gly Thr Gln 
        115                 120                 125             


Val Met Leu Cys Asn Pro Ile Cys Gly Val Ser Tyr Ala Leu Thr Val 
    130                 135                 140                 


Trp Arg Phe Phe Arg Asp Arg Thr Glu Glu Glu Glu Ile Ser Leu Ile 
145                 150                 155                 160 


His Phe Phe Gly Glu Glu Tyr Leu Glu Tyr Lys Lys Arg Val Pro Thr 
                165                 170                 175     


Gly Leu Pro Phe Ile Lys Gly Val Lys Val Asp Leu 
            180                 185             


<210>  5286
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS__Homo_sapiens__NP_036224

<400>  5286

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  5287
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSLG__Homo_sapiens__NP_001269979

<400>  5287

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Glu Ser Trp Asn Leu 
    290                 295                 300                 


Leu Leu Leu Leu Ser 
305                 


<210>  5288
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ID1__Homo_sapiens__NP_002156

<400>  5288

Met Lys Val Ala Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser 
1               5                   10                  15      


Cys Ala Leu Lys Ala Gly Lys Thr Ala Ser Gly Ala Gly Glu Val Val 
            20                  25                  30          


Arg Cys Leu Ser Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Gly 
        35                  40                  45              


Ala Gly Ala Arg Leu Pro Ala Leu Leu Asp Glu Gln Gln Val Asn Val 
    50                  55                  60                  


Leu Leu Tyr Asp Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val 
65                  70                  75                  80  


Pro Thr Leu Pro Gln Asn Arg Lys Val Ser Lys Val Glu Ile Leu Gln 
                85                  90                  95      


His Val Ile Asp Tyr Ile Arg Asp Leu Gln Leu Glu Leu Asn Ser Glu 
            100                 105                 110         


Ser Glu Val Gly Thr Pro Gly Gly Arg Gly Leu Pro Val Arg Ala Pro 
        115                 120                 125             


Leu Ser Thr Leu Asn Gly Glu Ile Ser Ala Leu Thr Ala Glu Ala Ala 
    130                 135                 140                 


Cys Val Pro Ala Asp Asp Arg Ile Leu Cys Arg 
145                 150                 155 


<210>  5289
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ID2__Homo_sapiens__NP_002157

<400>  5289

Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 
1               5                   10                  15      


Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 
            20                  25                  30          


Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 
        35                  40                  45              


Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Ser Lys Met Glu Ile 
    50                  55                  60                  


Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 
65                  70                  75                  80  


Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 
                85                  90                  95      


Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 
            100                 105                 110         


Leu Ser Leu Gln Ala Ser Glu Phe Pro Ser Glu Leu Met Ser Asn Asp 
        115                 120                 125             


Ser Lys Ala Leu Cys Gly 
    130                 


<210>  5290
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ID4__Homo_sapiens__NP_001537

<400>  5290

Met Lys Ala Val Ser Pro Val Arg Pro Ser Gly Arg Lys Ala Pro Ser 
1               5                   10                  15      


Gly Cys Gly Gly Gly Glu Leu Ala Leu Arg Cys Leu Ala Glu His Gly 
            20                  25                  30          


His Ser Leu Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Arg Cys Lys Ala Ala Glu Ala Ala Ala Asp Glu Pro Ala Leu Cys Leu 
    50                  55                  60                  


Gln Cys Asp Met Asn Asp Cys Tyr Ser Arg Leu Arg Arg Leu Val Pro 
65                  70                  75                  80  


Thr Ile Pro Pro Asn Lys Lys Val Ser Lys Val Glu Ile Leu Gln His 
                85                  90                  95      


Val Ile Asp Tyr Ile Leu Asp Leu Gln Leu Ala Leu Glu Thr His Pro 
            100                 105                 110         


Ala Leu Leu Arg Gln Pro Pro Pro Pro Ala Pro Pro His His Pro Ala 
        115                 120                 125             


Gly Thr Cys Pro Ala Ala Pro Pro Arg Thr Pro Leu Thr Ala Leu Asn 
    130                 135                 140                 


Thr Asp Pro Ala Gly Ala Val Asn Lys Gln Gly Asp Ser Ile Leu Cys 
145                 150                 155                 160 


Arg 
    


<210>  5291
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDE__Homo_sapiens__NP_001159418

<400>  5291

Met Ser Lys Leu Trp Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys 
1               5                   10                  15      


Ala Cys Leu Asn Phe Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro 
            20                  25                  30          


Leu His Cys Asn Met Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser 
        35                  40                  45              


Leu Asn Glu Tyr Ala Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp 
    50                  55                  60                  


Leu Gln Asn Thr Ile Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn 
65                  70                  75                  80  


Asp Lys Gln Pro Ile Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr 
                85                  90                  95      


Phe Glu Ile Asp Glu Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met 
            100                 105                 110         


Arg Ser Leu Asn Asn Phe Arg Ala Glu Gln Pro His Gln His Ala Met 
        115                 120                 125             


Tyr Tyr Leu Arg Leu Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu 
    130                 135                 140                 


Leu Lys Glu Ala Leu Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe 
145                 150                 155                 160 


Ile Pro Gln Leu Leu Ser Arg Leu His Ile Glu Ala Leu Leu His Gly 
                165                 170                 175     


Asn Ile Thr Lys Gln Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp 
            180                 185                 190         


Thr Leu Ile Glu His Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu 
        195                 200                 205             


Val Arg Tyr Arg Glu Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr 
    210                 215                 220                 


Gln Gln Arg Asn Glu Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr 
225                 230                 235                 240 


Gln Thr Asp Met Gln Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe 
                245                 250                 255     


Cys Gln Ile Ile Ser Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu 
            260                 265                 270         


Gln Leu Gly Tyr Ile Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile 
        275                 280                 285             


Gln Gly Leu Arg Phe Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu 
    290                 295                 300                 


Glu Ser Arg Val Glu Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu 
305                 310                 315                 320 


Asp Met Thr Glu Glu Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile 
                325                 330                 335     


Arg Arg Leu Asp Lys Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr 
            340                 345                 350         


Trp Gly Glu Ile Ile Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr 
        355                 360                 365             


Glu Val Ala Tyr Leu Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe 
    370                 375                 380                 


Tyr Lys Glu Met Leu Ala Val Asp Ala Pro Arg Arg His Lys Val Ser 
385                 390                 395                 400 


Val His Val Leu Ala Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu 
                405                 410                 415     


Phe Pro Cys Gln Asn Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro 
            420                 425                 430         


Gln Pro Glu Val Ile Gln Asn Met Thr Glu Phe Lys Arg Gly Leu Pro 
        435                 440                 445             


Leu Phe Pro Leu Val Lys Pro His Ile Asn Phe Met Ala Ala Lys Leu 
    450                 455                 460                 


<210>  5292
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDH1__Homo_sapiens__NP_001269315

<400>  5292

Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


<210>  5293
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDH2__Homo_sapiens__NP_001276839

<400>  5293

Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln Phe Ile Lys Glu 
1               5                   10                  15      


Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys Tyr Phe Asp Leu 
            20                  25                  30          


Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val Thr Ile Asp Ser 
        35                  40                  45              


Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys Cys Ala Thr Ile 
    50                  55                  60                  


Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu Lys Lys Met Trp 
65                  70                  75                  80  


Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe 
                85                  90                  95      


Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu Val Pro Gly Trp 
            100                 105                 110         


Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly Asp Gln Tyr Lys 
        115                 120                 125             


Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe Lys Met Val Phe 
    130                 135                 140                 


Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu Val Tyr Asn Phe 
145                 150                 155                 160 


Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr Asp Glu Ser Ile 
                165                 170                 175     


Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile Gln Lys Lys Trp 
            180                 185                 190         


Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys Ala Tyr Asp Gly 
        195                 200                 205             


Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys His Tyr Lys Thr 
    210                 215                 220                 


Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp 
225                 230                 235                 240 


Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe Val Trp Ala Cys 
                245                 250                 255     


Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu Ala Gln Gly Phe 
            260                 265                 270         


Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys 
        275                 280                 285             


Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg 
    290                 295                 300                 


Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro Ile Ala Ser Ile 
305                 310                 315                 320 


Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys Leu Asp Gly Asn 
                325                 330                 335     


Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys Val Cys Val Glu 
            340                 345                 350         


Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala Gly Cys Ile His 
        355                 360                 365             


Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu Asn Thr Thr Asp 
    370                 375                 380                 


Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala Leu Gly Arg Gln 
385                 390                 395                 400 


<210>  5294
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDH3B__Homo_sapiens__NP_001245313

<400>  5294

Met Ala Ala Leu Ser Gly Val Arg Trp Leu Thr Arg Ala Leu Val Ser 
1               5                   10                  15      


Ala Gly Asn Pro Gly Ala Trp Arg Gly Leu Ser Thr Ser Ala Ala Ala 
            20                  25                  30          


His Ala Ala Ser Arg Ser Gln Ala Glu Asp Val Arg Val Glu Gly Ser 
        35                  40                  45              


Phe Pro Val Thr Met Leu Pro Gly Asp Gly Val Gly Pro Glu Leu Met 
    50                  55                  60                  


His Ala Val Lys Glu Val Phe Lys Ala Ala Ala Val Pro Val Glu Phe 
65                  70                  75                  80  


Gln Glu His His Leu Ser Glu Val Gln Asn Met Ala Ser Glu Glu Lys 
                85                  90                  95      


Leu Glu Gln Val Leu Ser Ser Met Lys Glu Asn Lys Val Ala Ile Ile 
            100                 105                 110         


Gly Lys Ile His Thr Pro Met Glu Tyr Lys Gly Glu Leu Ala Ser Tyr 
        115                 120                 125             


Asp Met Arg Leu Arg Arg Lys Leu Asp Leu Phe Ala Asn Val Val His 
    130                 135                 140                 


Val Lys Ser Leu Pro Gly Tyr Met Thr Arg His Asn Asn Leu Asp Leu 
145                 150                 155                 160 


Val Ile Ile Arg Glu Gln Thr Glu Gly Glu Tyr Ser Ser Leu Glu His 
                165                 170                 175     


Glu Ser Ala Arg Gly Val Ile Glu Cys Leu Lys Ile Val Thr Arg Ala 
            180                 185                 190         


Lys Ser Gln Arg Ile Ala Lys Phe Ala Phe Asp Tyr Ala Thr Lys Lys 
        195                 200                 205             


Gly Arg Gly Lys Val Thr Ala Val His Lys Ala Asn Ile Met Lys Leu 
    210                 215                 220                 


Gly Asp Gly Leu Phe Leu Gln Cys Cys Glu Glu Val Ala Glu Leu Tyr 
225                 230                 235                 240 


Pro Lys Ile Lys Phe Glu Thr Met Ile Ile Asp Asn Cys Cys Met Gln 
                245                 250                 255     


Leu Val Gln Asn Pro Tyr Gln Phe Asp Val Leu Val Met Pro Asn Leu 
            260                 265                 270         


Tyr Gly Asn Ile Ile Asp Asn Leu Ala Ala Gly Leu Val Gly Gly Ala 
        275                 280                 285             


Gly Val Val Pro Gly Glu Ser Tyr Ser Ala Glu Tyr Ala Val Phe Glu 
    290                 295                 300                 


Thr Gly Ala Arg His Pro Phe Ala Gln Ala Val Gly Arg Asn Ile Ala 
305                 310                 315                 320 


Asn Pro Thr Ala Met Leu Leu Ser Ala Ser Asn Met Leu Arg His Leu 
                325                 330                 335     


Asn Leu Glu Tyr His Ser Ser Met Ile Ala Asp Ala Val Lys Lys Val 
            340                 345                 350         


Ile Lys Val Gly Lys Ile Pro Ser Ala Val Pro Ser Phe Leu Leu His 
        355                 360                 365             


Pro Leu Pro Phe Ser Trp Ala Ile 
    370                 375     


<210>  5295
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDNK__Homo_sapiens__NP_001001551

<400>  5295

Met Ala Ala Pro Gly Ala Leu Leu Val Met Gly Val Ser Gly Ser Gly 
1               5                   10                  15      


Lys Ser Thr Val Gly Ala Leu Leu Ala Ser Glu Leu Gly Trp Lys Phe 
            20                  25                  30          


Tyr Asp Ala Asp Asp Tyr His Pro Glu Glu Asn Arg Arg Lys Met Gly 
        35                  40                  45              


Lys Gly Ile Pro Leu Asn Asp Gln Asp Arg Ile Pro Trp Leu Cys Asn 
    50                  55                  60                  


Leu His Asp Ile Leu Leu Arg Asp Val Ala Ser Gly Gln Arg Val Val 
65                  70                  75                  80  


Leu Ala Cys Ser Ala Leu Lys Lys Thr Tyr Arg Asp Ile Leu Thr Gln 
                85                  90                  95      


Gly Lys Asp Gly Val Ala Leu Lys Cys Glu Glu Ser Gly Lys Glu Ala 
            100                 105                 110         


Lys Gln Ala Glu Met Gln Leu Leu Val Val His Leu Ser Gly Ser Phe 
        115                 120                 125             


Glu Val Ile Ser Gly Arg Leu Leu Lys Arg Glu Gly His Phe Met Pro 
    130                 135                 140                 


Pro Glu Leu Leu Gln Ser Gln Phe Glu Thr Leu Glu Pro Pro Ala Ala 
145                 150                 155                 160 


Pro Glu Asn Phe Ile Gln Ile Ser Val Asp Lys Asn Val Ser Glu Ile 
                165                 170                 175     


Ile Ala Thr Ile Met Glu Thr Leu Lys Met Lys 
            180                 185         


<210>  5296
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDO1__Homo_sapiens__NP_002155

<400>  5296

Met Ala His Ala Met Glu Asn Ser Trp Thr Ile Ser Lys Glu Tyr His 
1               5                   10                  15      


Ile Asp Glu Glu Val Gly Phe Ala Leu Pro Asn Pro Gln Glu Asn Leu 
            20                  25                  30          


Pro Asp Phe Tyr Asn Asp Trp Met Phe Ile Ala Lys His Leu Pro Asp 
        35                  40                  45              


Leu Ile Glu Ser Gly Gln Leu Arg Glu Arg Val Glu Lys Leu Asn Met 
    50                  55                  60                  


Leu Ser Ile Asp His Leu Thr Asp His Lys Ser Gln Arg Leu Ala Arg 
65                  70                  75                  80  


Leu Val Leu Gly Cys Ile Thr Met Ala Tyr Val Trp Gly Lys Gly His 
                85                  90                  95      


Gly Asp Val Arg Lys Val Leu Pro Arg Asn Ile Ala Val Pro Tyr Cys 
            100                 105                 110         


Gln Leu Ser Lys Lys Leu Glu Leu Pro Pro Ile Leu Val Tyr Ala Asp 
        115                 120                 125             


Cys Val Leu Ala Asn Trp Lys Lys Lys Asp Pro Asn Lys Pro Leu Thr 
    130                 135                 140                 


Tyr Glu Asn Met Asp Val Leu Phe Ser Phe Arg Asp Gly Asp Cys Ser 
145                 150                 155                 160 


Lys Gly Phe Phe Leu Val Ser Leu Leu Val Glu Ile Ala Ala Ala Ser 
                165                 170                 175     


Ala Ile Lys Val Ile Pro Thr Val Phe Lys Ala Met Gln Met Gln Glu 
            180                 185                 190         


Arg Asp Thr Leu Leu Lys Ala Leu Leu Glu Ile Ala Ser Cys Leu Glu 
        195                 200                 205             


Lys Ala Leu Gln Val Phe His Gln Ile His Asp His Val Asn Pro Lys 
    210                 215                 220                 


Ala Phe Phe Ser Val Leu Arg Ile Tyr Leu Ser Gly Trp Lys Gly Asn 
225                 230                 235                 240 


Pro Gln Leu Ser Asp Gly Leu Val Tyr Glu Gly Phe Trp Glu Asp Pro 
                245                 250                 255     


Lys Glu Phe Ala Gly Gly Ser Ala Gly Gln Ser Ser Val Phe Gln Cys 
            260                 265                 270         


Phe Asp Val Leu Leu Gly Ile Gln Gln Thr Ala Gly Gly Gly His Ala 
        275                 280                 285             


Ala Gln Phe Leu Gln Asp Met Arg Arg Tyr Met Pro Pro Ala His Arg 
    290                 295                 300                 


Asn Phe Leu Cys Ser Leu Glu Ser Asn Pro Ser Val Arg Glu Phe Val 
305                 310                 315                 320 


Leu Ser Lys Gly Asp Ala Gly Leu Arg Glu Ala Tyr Asp Ala Cys Val 
                325                 330                 335     


Lys Ala Leu Val Ser Leu Arg Ser Tyr His Leu Gln Ile Val Thr Lys 
            340                 345                 350         


Tyr Ile Leu Ile Pro Ala Ser Gln Gln Pro Lys Glu Asn Lys Thr Ser 
        355                 360                 365             


Glu Asp Pro Ser Lys Leu Glu Ala Lys Gly Thr Gly Gly Thr Asp Leu 
    370                 375                 380                 


Met Asn Phe Leu Lys Thr Val Arg Ser Thr Thr Glu Lys Ser Leu Leu 
385                 390                 395                 400 


Lys Glu Gly 
            


<210>  5297
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDO2__Homo_sapiens__NP_919270

<400>  5297

Met Leu His Phe His Tyr Tyr Asp Thr Ser Asn Lys Ile Met Glu Pro 
1               5                   10                  15      


His Arg Pro Asn Val Lys Thr Ala Val Pro Leu Ser Leu Glu Ser Tyr 
            20                  25                  30          


His Ile Ser Glu Glu Tyr Gly Phe Leu Leu Pro Asp Ser Leu Lys Glu 
        35                  40                  45              


Leu Pro Asp His Tyr Arg Pro Trp Met Glu Ile Ala Asn Lys Leu Pro 
    50                  55                  60                  


Gln Leu Ile Asp Ala His Gln Leu Gln Ala His Val Asp Lys Met Pro 
65                  70                  75                  80  


Leu Leu Ser Cys Gln Phe Leu Lys Gly His Arg Glu Gln Arg Leu Ala 
                85                  90                  95      


His Leu Val Leu Ser Phe Leu Thr Met Gly Tyr Val Trp Gln Glu Gly 
            100                 105                 110         


Glu Ala Gln Pro Ala Glu Val Leu Pro Arg Asn Leu Ala Leu Pro Phe 
        115                 120                 125             


Val Glu Val Ser Arg Asn Leu Gly Leu Pro Pro Ile Leu Val His Ser 
    130                 135                 140                 


Asp Leu Val Leu Thr Asn Trp Thr Lys Lys Asp Pro Asp Gly Phe Leu 
145                 150                 155                 160 


Glu Ile Gly Asn Leu Glu Thr Ile Ile Ser Phe Pro Gly Gly Glu Ser 
                165                 170                 175     


Leu His Gly Phe Ile Leu Val Thr Ala Leu Val Glu Lys Glu Ala Val 
            180                 185                 190         


Pro Gly Ile Lys Ala Leu Val Gln Ala Thr Asn Ala Ile Leu Gln Pro 
        195                 200                 205             


Asn Gln Glu Ala Leu Leu Gln Ala Leu Gln Arg Leu Arg Leu Ser Ile 
    210                 215                 220                 


Gln Asp Ile Thr Lys Thr Leu Gly Gln Met His Asp Tyr Val Asp Pro 
225                 230                 235                 240 


Asp Ile Phe Tyr Ala Gly Ile Arg Ile Phe Leu Ser Gly Trp Lys Asp 
                245                 250                 255     


Asn Pro Ala Met Pro Ala Gly Leu Met Tyr Glu Gly Val Ser Gln Glu 
            260                 265                 270         


Pro Leu Lys Tyr Ser Gly Gly Ser Ala Ala Gln Ser Thr Val Leu His 
        275                 280                 285             


Ala Phe Asp Glu Phe Leu Gly Ile Arg His Ser Lys Glu Ser Gly Asp 
    290                 295                 300                 


Phe Leu Tyr Arg Met Arg Asp Tyr Met Pro Pro Ser His Lys Ala Phe 
305                 310                 315                 320 


Ile Glu Asp Ile His Ser Ala Pro Ser Leu Arg Asp Tyr Ile Leu Ser 
                325                 330                 335     


Ser Gly Gln Asp His Leu Leu Thr Ala Tyr Asn Gln Cys Val Gln Ala 
            340                 345                 350         


Leu Ala Glu Leu Arg Ser Tyr His Ile Thr Met Val Thr Lys Tyr Leu 
        355                 360                 365             


Ile Thr Ala Ala Ala Lys Ala Lys His Gly Lys Pro Asn His Leu Pro 
    370                 375                 380                 


Gly Pro Pro Gln Ala Leu Lys Asp Arg Gly Thr Gly Gly Thr Ala Val 
385                 390                 395                 400 


Met Ser Phe Leu Lys Ser Val Arg Asp Lys Thr Leu Glu Ser Ile Leu 
                405                 410                 415     


His Pro Arg Gly 
            420 


<210>  5298
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDS__Homo_sapiens__NP_000193

<400>  5298

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  5299
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IDUA__Homo_sapiens__NP_000194

<400>  5299

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  5300
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IER2__Homo_sapiens__NP_004898

<400>  5300

Met Glu Val Gln Lys Glu Ala Gln Arg Ile Met Thr Leu Ser Val Trp 
1               5                   10                  15      


Lys Met Tyr His Ser Arg Met Gln Arg Gly Gly Leu Arg Leu His Arg 
            20                  25                  30          


Ser Leu Gln Leu Ser Leu Val Met Arg Ser Ala Arg Glu Leu Tyr Leu 
        35                  40                  45              


Ser Ala Lys Val Glu Ala Leu Glu Pro Glu Val Ser Leu Pro Ala Ala 
    50                  55                  60                  


Leu Pro Ser Asp Pro Arg Leu His Pro Pro Arg Glu Ala Glu Ser Thr 
65                  70                  75                  80  


Ala Glu Thr Ala Thr Pro Asp Gly Glu His Pro Phe Pro Glu Pro Met 
                85                  90                  95      


Asp Thr Gln Glu Ala Pro Thr Ala Glu Glu Thr Ser Ala Cys Cys Ala 
            100                 105                 110         


Pro Arg Pro Ala Lys Val Ser Arg Lys Arg Arg Ser Ser Ser Leu Ser 
        115                 120                 125             


Asp Gly Gly Asp Ala Gly Leu Val Pro Ser Lys Lys Ala Arg Leu Glu 
    130                 135                 140                 


Glu Lys Glu Glu Glu Glu Gly Ala Ser Ser Glu Val Ala Asp Arg Leu 
145                 150                 155                 160 


Gln Pro Pro Pro Ala Gln Ala Glu Gly Ala Phe Pro Asn Leu Ala Arg 
                165                 170                 175     


Val Leu Gln Arg Arg Phe Ser Gly Leu Leu Asn Cys Ser Pro Ala Ala 
            180                 185                 190         


Pro Pro Thr Ala Pro Pro Ala Cys Glu Ala Lys Pro Ala Cys Arg Pro 
        195                 200                 205             


Ala Asp Ser Met Leu Asn Val Leu Val Arg Ala Val Val Ala Phe 
    210                 215                 220             


<210>  5301
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IER3__Homo_sapiens__NP_003888

<400>  5301

Met Cys His Ser Arg Ser Cys His Pro Thr Met Thr Ile Leu Gln Ala 
1               5                   10                  15      


Pro Thr Pro Ala Pro Ser Thr Ile Pro Gly Pro Arg Arg Gly Ser Gly 
            20                  25                  30          


Pro Glu Ile Phe Thr Phe Asp Pro Leu Pro Glu Pro Ala Ala Ala Pro 
        35                  40                  45              


Ala Gly Arg Pro Ser Ala Ser Arg Gly His Arg Lys Arg Ser Arg Arg 
    50                  55                  60                  


Val Leu Tyr Pro Arg Val Val Arg Arg Gln Leu Pro Val Glu Glu Pro 
65                  70                  75                  80  


Asn Pro Ala Lys Arg Leu Leu Phe Leu Leu Leu Thr Ile Val Phe Cys 
                85                  90                  95      


Gln Ile Leu Met Ala Glu Glu Gly Val Pro Ala Pro Leu Pro Pro Glu 
            100                 105                 110         


Asp Ala Pro Asn Ala Ala Ser Leu Ala Pro Thr Pro Val Ser Ala Val 
        115                 120                 125             


Leu Glu Pro Phe Asn Leu Thr Ser Glu Pro Ser Asp Tyr Ala Leu Asp 
    130                 135                 140                 


Leu Ser Thr Phe Leu Gln Gln His Pro Ala Ala Phe 
145                 150                 155     


<210>  5302
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IER3IP1__Homo_sapiens__NP_057181

<400>  5302

Met Ala Phe Thr Leu Tyr Ser Leu Leu Gln Ala Ala Leu Leu Cys Val 
1               5                   10                  15      


Asn Ala Ile Ala Val Leu His Glu Glu Arg Phe Leu Lys Asn Ile Gly 
            20                  25                  30          


Trp Gly Thr Asp Gln Gly Ile Gly Gly Phe Gly Glu Glu Pro Gly Ile 
        35                  40                  45              


Lys Ser Gln Leu Met Asn Leu Ile Arg Ser Val Arg Thr Val Met Arg 
    50                  55                  60                  


Val Pro Leu Ile Ile Val Asn Ser Ile Ala Ile Val Leu Leu Leu Leu 
65                  70                  75                  80  


Phe Gly 
        


<210>  5303
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IER5__Homo_sapiens__NP_057629

<400>  5303

Met Glu Phe Lys Leu Glu Ala His Arg Ile Val Ser Ile Ser Leu Gly 
1               5                   10                  15      


Lys Ile Tyr Asn Ser Arg Val Gln Arg Gly Gly Ile Lys Leu His Lys 
            20                  25                  30          


Asn Leu Leu Val Ser Leu Val Leu Arg Ser Ala Arg Gln Val Tyr Leu 
        35                  40                  45              


Ser Asp Pro Cys Pro Gly Leu Tyr Leu Ala Gly Pro Ala Gly Thr Pro 
    50                  55                  60                  


Ala Pro Pro Pro Gln Gln Gln Pro Gly Glu Pro Ala Ala Gly Pro Pro 
65                  70                  75                  80  


Ala Gly Trp Gly Glu Pro Pro Pro Pro Ala Ala Arg Ala Ser Trp Pro 
                85                  90                  95      


Glu Thr Glu Pro Gln Pro Glu Arg Ser Ser Val Ser Asp Ala Pro Arg 
            100                 105                 110         


Val Gly Asp Glu Val Pro Val Ala Thr Val Thr Gly Val Gly Asp Val 
        115                 120                 125             


Phe Gln Gly Gly Glu Ala Asp Ala Thr Glu Ala Ala Trp Ser Arg Val 
    130                 135                 140                 


Glu Gly Pro Arg Gln Ala Ala Ala Arg Glu Ala Glu Gly Thr Ala Gly 
145                 150                 155                 160 


Gly Trp Gly Val Phe Pro Glu Val Ser Arg Ala Ala Arg Arg Pro Cys 
                165                 170                 175     


Gly Cys Pro Leu Gly Gly Glu Asp Pro Pro Gly Thr Pro Ala Ala Thr 
            180                 185                 190         


Pro Arg Ala Ala Cys Cys Cys Ala Pro Gln Pro Ala Glu Asp Glu Pro 
        195                 200                 205             


Pro Ala Pro Pro Ala Val Cys Pro Arg Lys Arg Cys Ala Ala Gly Val 
    210                 215                 220                 


Gly Gly Gly Pro Ala Gly Cys Pro Ala Pro Gly Ser Thr Pro Leu Lys 
225                 230                 235                 240 


Lys Pro Arg Arg Asn Leu Glu Gln Pro Pro Ser Gly Gly Glu Asp Asp 
                245                 250                 255     


Asp Ala Glu Glu Met Glu Thr Gly Asn Val Ala Asn Leu Ile Ser Ile 
            260                 265                 270         


Phe Gly Ser Ser Phe Ser Gly Leu Leu Arg Lys Ser Pro Gly Gly Gly 
        275                 280                 285             


Arg Glu Glu Glu Glu Gly Glu Glu Ser Gly Pro Glu Ala Ala Glu Pro 
    290                 295                 300                 


Gly Gln Ile Cys Cys Asp Lys Pro Val Leu Arg Asp Met Asn Pro Trp 
305                 310                 315                 320 


Ser Thr Ala Ile Val Ala Phe 
                325         


<210>  5304
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFFO1__Homo_sapiens__NP_001034759

<400>  5304

Met Asn Pro Leu Phe Gly Pro Asn Leu Phe Leu Leu Gln Gln Glu Gln 
1               5                   10                  15      


Gln Gly Leu Ala Gly Pro Leu Gly Asp Ser Leu Gly Gly Asp His Phe 
            20                  25                  30          


Ala Gly Gly Gly Asp Leu Pro Pro Ala Pro Leu Ser Pro Ala Gly Pro 
        35                  40                  45              


Ala Ala Tyr Ser Pro Pro Gly Pro Gly Pro Ala Pro Pro Ala Ala Met 
    50                  55                  60                  


Ala Leu Arg Asn Asp Leu Gly Ser Asn Ile Asn Val Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Leu Arg Phe Arg Cys Phe Leu Ala Lys Val His Glu Leu Glu Arg 
                85                  90                  95      


Arg Asn Arg Leu Leu Glu Lys Gln Leu Gln Gln Ala Leu Glu Glu Gly 
            100                 105                 110         


Lys Gln Gly Arg Arg Gly Leu Gly Arg Arg Asp Gln Ala Val Gln Thr 
        115                 120                 125             


Gly Phe Val Ser Pro Ile Arg Pro Leu Gly Leu Gln Leu Gly Ala Arg 
    130                 135                 140                 


Pro Ala Ala Val Cys Ser Pro Ser Ala Arg Val Leu Gly Ser Pro Ala 
145                 150                 155                 160 


Arg Ser Pro Ala Gly Pro Leu Ala Pro Ser Ala Ala Ser Leu Ser Ser 
                165                 170                 175     


Ser Ser Thr Ser Thr Ser Thr Thr Tyr Ser Ser Ser Ala Arg Phe Met 
            180                 185                 190         


Pro Gly Thr Ile Trp Ser Phe Ser His Ala Arg Arg Leu Gly Pro Gly 
        195                 200                 205             


Leu Glu Pro Thr Leu Val Gln Gly Pro Gly Leu Ser Trp Val His Pro 
    210                 215                 220                 


Asp Gly Val Gly Val Gln Ile Asp Thr Ile Thr Pro Glu Ile Arg Ala 
225                 230                 235                 240 


Leu Tyr Asn Val Leu Ala Lys Val Lys Arg Glu Arg Asp Glu Tyr Lys 
                245                 250                 255     


Arg Arg Trp Glu Glu Glu Tyr Thr Val Arg Ile Gln Leu Gln Asp Arg 
            260                 265                 270         


Val Asn Glu Leu Gln Glu Glu Ala Gln Glu Ala Asp Ala Cys Gln Glu 
        275                 280                 285             


Glu Leu Ala Leu Lys Val Glu Gln Leu Lys Ala Glu Leu Val Val Phe 
    290                 295                 300                 


Lys Gly Leu Met Ser Asn Asn Leu Ser Glu Leu Asp Thr Lys Ile Gln 
305                 310                 315                 320 


Glu Lys Ala Met Lys Val Asp Met Asp Ile Cys Arg Arg Ile Asp Ile 
                325                 330                 335     


Thr Ala Lys Leu Cys Asp Val Ala Gln Gln Arg Asn Cys Glu Asp Met 
            340                 345                 350         


Ile Gln Met Phe Gln Lys Lys Leu Val Pro Ser Met Gly Gly Arg Lys 
        355                 360                 365             


Arg Glu Arg Lys Ala Ala Val Glu Glu Asp Thr Ser Leu Ser Glu Ser 
    370                 375                 380                 


Glu Gly Pro Arg Gln Pro Asp Gly Asp Glu Glu Glu Ser Thr Ala Leu 
385                 390                 395                 400 


Ser Ile Asn Glu Glu Met Gln Arg Met Leu Asn Gln Leu Arg Glu Tyr 
                405                 410                 415     


Asp Phe Glu Asp Asp Cys Asp Ser Leu Thr Trp Glu Glu Thr Glu Glu 
            420                 425                 430         


Thr Leu Leu Leu Trp Glu Asp Phe Ser Gly Tyr Ala Met Ala Ala Ala 
        435                 440                 445             


Glu Ala Gln Gly Glu Gln Gln Glu Asp Ser Leu Glu Lys Val Ile Lys 
    450                 455                 460                 


Asp Thr Glu Ser Leu Phe Lys Thr Arg Glu Lys Glu Tyr Gln Glu Thr 
465                 470                 475                 480 


Ile Asp Gln Ile Glu Leu Glu Leu Ala Thr Ala Lys Asn Asp Met Asn 
                485                 490                 495     


Arg His Leu His Glu Tyr Met Glu Met Cys Ser Met Lys Arg Gly Leu 
            500                 505                 510         


Asp Val Gln Met Glu Thr Cys Arg Arg Leu Ile Thr Gln Ser Gly Asp 
        515                 520                 525             


Arg Lys Ser Pro Ala Phe Thr Ala Val Pro Leu Ser Asp Pro Pro Pro 
    530                 535                 540                 


Pro Pro Ser Glu Ala Glu Asp Ser Asp Arg Asp Val Ser Ser Asp Ser 
545                 550                 555                 560 


Ser Met Arg 
            


<210>  5305
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFFO2__Homo_sapiens__XP_011538932

<400>  5305

Met Val Asn Ser Leu Leu Phe Gly Glu Met Ala Leu Ala Phe Gly Cys 
1               5                   10                  15      


Pro Pro Gly Gly Gly Gly Gly Gly Cys Pro Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ala Gly Pro Gly Pro Ser Pro Val Thr Ala Ala Leu Arg Asp 
        35                  40                  45              


Asp Leu Gly Ser Asn Ile His Leu Leu Lys Gly Leu Asn Val Arg Phe 
    50                  55                  60                  


Arg Cys Phe Leu Ala Lys Val His Glu Leu Glu Arg Arg Asn Arg Leu 
65                  70                  75                  80  


Leu Glu Lys Gln Leu Glu Gln Gln Gln Ser Glu Arg Glu Arg Arg Leu 
                85                  90                  95      


Arg Tyr Lys Thr Phe Ser Arg Glu Gln Ala Val Gln Thr Gly Pro Glu 
            100                 105                 110         


Leu Leu Arg Pro Pro Ala Pro Gly Gly Gly His Gly Leu Ser Ser Gly 
        115                 120                 125             


Ala Ala Ala Gly Ala Asn Ala Asn Ala Val Ala Leu Gly Gly Leu Pro 
    130                 135                 140                 


Pro Gly Gly Gly Ser His Pro Gln His Tyr Gly Arg Leu Pro Gly Thr 
145                 150                 155                 160 


Ile Trp Ser Tyr Thr Gln Val Arg Arg Thr Gly Gly Gly Gly Val Glu 
                165                 170                 175     


Thr Val Gln Gly Pro Gly Val Ser Trp Val His Pro Asp Gly Val Gly 
            180                 185                 190         


Val Gln Ile Asp Thr Ile Thr Pro Glu Ile Arg Ala Leu Tyr Asn Val 
        195                 200                 205             


Leu Ala Lys Val Lys Arg Glu Arg Asp Glu Tyr Lys Arg Arg Trp Glu 
    210                 215                 220                 


Glu Glu Leu Ala Lys Arg Met Asn Leu Gln Thr Met Val Asp Thr Leu 
225                 230                 235                 240 


Gln Glu Ala Ala Gln Glu Ala Asp Ala Ile Gln Glu Glu Met Asn Glu 
                245                 250                 255     


Lys Ile Glu Arg Leu Lys Ala Glu Leu Val Val Phe Lys Gly Leu Met 
            260                 265                 270         


Ser Asp Val Val Pro Lys Lys Lys Glu Arg Lys Val Ala Ser Asp Asp 
        275                 280                 285             


Asp Ile Ser Glu Gln Asp Gly Glu Val Asn Arg Phe Ser Asp Asp Glu 
    290                 295                 300                 


Val Gly Ser Met Asn Ile Thr Asp Glu Met Lys Arg Met Phe Asn Gln 
305                 310                 315                 320 


Leu Arg Glu Thr Phe Asp Phe Asp Asp Asp Cys Asp Ser Leu Thr Trp 
                325                 330                 335     


Glu Glu Asn Glu Asp Thr Leu Leu Leu Trp Glu Asp Phe Thr Asn Cys 
            340                 345                 350         


Asn Pro Thr Ile Asp Leu Gln Gly Glu Gln Glu Glu Asn Leu Gly Asn 
        355                 360                 365             


Leu Ile His Glu Thr Glu Ser Phe Phe Lys Thr Arg Asp Lys Glu Tyr 
    370                 375                 380                 


Gln Glu Thr Ile Gly Gln Ile Glu Leu Glu Leu Ala Thr Ala Lys Ser 
385                 390                 395                 400 


Asp Met Asn Arg His Leu His Glu Tyr Met Glu Met Cys Ser Met Lys 
                405                 410                 415     


Arg Gly Leu Asp Val Gln Met Glu Thr Cys Arg Arg Leu Ile Lys Gly 
            420                 425                 430         


Ser Ala Asp Arg Asn Ser Pro Ser Pro Ser Ser Val Ala Ser Ser Asp 
        435                 440                 445             


Ser Gly Ser Thr Asp Glu Ile Gln Asp Glu Phe Glu Arg Glu Ala Asp 
    450                 455                 460                 


Val Glu Pro Met Val Ser 
465                 470 


<210>  5306
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI16__Homo_sapiens__NP_001193496

<400>  5306

Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Asn 
        115                 120                 125             


Pro Lys Thr Val Ala Lys Cys Gln Val Thr Pro Arg Arg Asn Val Leu 
    130                 135                 140                 


Gln Lys Arg Pro Val Ile Val Lys Val Leu Ser Thr Thr Lys Pro Phe 
145                 150                 155                 160 


Glu Tyr Glu Thr Pro Glu Met Glu Lys Lys Ile Met Phe His Ala Thr 
                165                 170                 175     


Val Ala Thr Gln Thr Gln Phe Phe His Val Lys Val Leu Asn Thr Ser 
            180                 185                 190         


Leu Lys Glu Lys Phe Asn Gly Lys Lys Ile Ile Ile Ile Ser Asp Tyr 
        195                 200                 205             


Leu Glu Tyr Asp Ser Leu Leu Glu Val Asn Glu Glu Ser Thr Val Ser 
    210                 215                 220                 


Glu Ala Gly Pro Asn Gln Thr Phe Glu Val Pro Asn Lys Ile Ile Asn 
225                 230                 235                 240 


Arg Ala Lys Glu Thr Leu Lys Ile Asp Ile Leu His Lys Gln Ala Ser 
                245                 250                 255     


Gly Asn Ile Val Tyr Gly Val Phe Met Leu His Lys Lys Thr Val Asn 
            260                 265                 270         


Gln Lys Thr Thr Ile Tyr Glu Ile Gln Asp Asp Arg Gly Lys Met Asp 
        275                 280                 285             


Val Val Gly Thr Gly Gln Cys His Asn Ile Pro Cys Glu Glu Gly Asp 
    290                 295                 300                 


Lys Leu Gln Leu Phe Cys Phe Arg Leu Arg Lys Lys Asn Gln Met Ser 
305                 310                 315                 320 


Lys Leu Ile Ser Glu Met His Ser Phe Ile Gln Ile Lys Lys Lys Thr 
                325                 330                 335     


Asn Pro Arg Asn Asn Asp Pro Lys Ser Met Lys Leu Pro Gln Glu Gln 
            340                 345                 350         


Arg Gln Leu Pro Tyr Pro Ser Glu Ala Ser Thr Thr Phe Pro Glu Ser 
        355                 360                 365             


His Leu Arg Thr Pro Gln Met Pro Pro Thr Thr Pro Ser Ser Ser Phe 
    370                 375                 380                 


Phe Thr Lys Lys Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met 
385                 390                 395                 400 


Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met 
                405                 410                 415     


Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Leu Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser 
            500                 505                 510         


Ile Glu Asp Ser Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn 
        515                 520                 525             


Ala Thr Glu Ser Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe 
    530                 535                 540                 


His Ala Thr Val Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe 
545                 550                 555                 560 


Asn Ile Asp Leu Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile 
                565                 570                 575     


Ala Asn Tyr Val Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr 
            580                 585                 590         


Leu Val Ala Asp Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly 
        595                 600                 605             


Leu Ile Arg Ser Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser 
    610                 615                 620                 


Gln Thr Lys Gly Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys 
625                 630                 635                 640 


Asn Val Arg Gly Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly 
                645                 650                 655     


Lys Met Glu Val Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu 
            660                 665                 670         


Glu Gly Asp Lys Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser 
        675                 680                 685             


Gly Asn Thr Gly Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val 
    690                 695                 700                 


Ile Lys Thr Arg Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser 
705                 710                 715                 720 


Met Glu Thr Ser Pro Asp Phe Phe Phe 
                725                 


<210>  5307
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI27__Homo_sapiens__NP_001275885

<400>  5307

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Met Ala Ala Val Pro 
        35                  40                  45              


Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser 
    50                  55                  60                  


Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly 
65                  70                  75                  80  


Gly Val Ala Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala 
                85                  90                  95      


Thr Gly Leu Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser 
            100                 105                 110         


Ala Ile Ala Ala Val Ile Ala Arg Phe Tyr 
        115                 120         


<210>  5308
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI30__Homo_sapiens__NP_006323

<400>  5308

Met Thr Leu Ser Pro Leu Leu Leu Phe Leu Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Asp Val Pro Thr Ala Ala Val Gln Ala Ser Pro Leu Gln Ala Leu 
            20                  25                  30          


Asp Phe Phe Gly Asn Gly Pro Pro Val Asn Tyr Lys Thr Gly Asn Leu 
        35                  40                  45              


Tyr Leu Arg Gly Pro Leu Lys Lys Ser Asn Ala Pro Leu Val Asn Val 
    50                  55                  60                  


Thr Leu Tyr Tyr Glu Ala Leu Cys Gly Gly Cys Arg Ala Phe Leu Ile 
65                  70                  75                  80  


Arg Glu Leu Phe Pro Thr Trp Leu Leu Val Met Glu Ile Leu Asn Val 
                85                  90                  95      


Thr Leu Val Pro Tyr Gly Asn Ala Gln Glu Gln Asn Val Ser Gly Arg 
            100                 105                 110         


Trp Glu Phe Lys Cys Gln His Gly Glu Glu Glu Cys Lys Phe Asn Lys 
        115                 120                 125             


Val Glu Ala Cys Val Leu Asp Glu Leu Asp Met Glu Leu Ala Phe Leu 
    130                 135                 140                 


Thr Ile Val Cys Met Glu Glu Phe Glu Asp Met Glu Arg Ser Leu Pro 
145                 150                 155                 160 


Leu Cys Leu Gln Leu Tyr Ala Pro Gly Leu Ser Pro Asp Thr Ile Met 
                165                 170                 175     


Glu Cys Ala Met Gly Asp Arg Gly Met Gln Leu Met His Ala Asn Ala 
            180                 185                 190         


Gln Arg Thr Asp Ala Leu Gln Pro Pro His Glu Tyr Val Pro Trp Val 
        195                 200                 205             


Thr Val Asn Gly Lys Pro Leu Glu Asp Gln Thr Gln Leu Leu Thr Leu 
    210                 215                 220                 


Val Cys Gln Leu Tyr Gln Gly Lys Lys Pro Asp Val Cys Pro Ser Ser 
225                 230                 235                 240 


Thr Ser Ser Leu Arg Ser Val Cys Phe Lys 
                245                 250 


<210>  5309
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI35__Homo_sapiens__NP_005524

<400>  5309

Met Ser Ala Pro Leu Asp Ala Ala Leu His Ala Leu Gln Glu Glu Gln 
1               5                   10                  15      


Ala Arg Leu Lys Met Arg Leu Trp Asp Leu Gln Gln Leu Arg Lys Glu 
            20                  25                  30          


Leu Gly Asp Ser Pro Lys Asp Lys Val Pro Phe Ser Val Pro Lys Ile 
        35                  40                  45              


Pro Leu Val Phe Arg Gly His Thr Gln Gln Asp Pro Glu Val Pro Lys 
    50                  55                  60                  


Ser Leu Val Ser Asn Leu Arg Ile His Cys Pro Leu Leu Ala Gly Ser 
65                  70                  75                  80  


Ala Leu Ile Thr Phe Asp Asp Pro Lys Val Ala Glu Gln Val Leu Gln 
                85                  90                  95      


Gln Lys Glu His Thr Ile Asn Met Glu Glu Cys Arg Leu Arg Val Gln 
            100                 105                 110         


Val Gln Pro Leu Glu Leu Pro Met Val Thr Thr Ile Gln Val Met Met 
        115                 120                 125             


Ser Ser Gln Leu Ser Gly Arg Arg Val Leu Val Thr Gly Phe Pro Ala 
    130                 135                 140                 


Ser Leu Arg Leu Ser Glu Glu Glu Leu Leu Asp Lys Leu Glu Ile Phe 
145                 150                 155                 160 


Phe Gly Lys Thr Arg Asn Gly Gly Gly Asp Val Asp Val Arg Glu Leu 
                165                 170                 175     


Leu Pro Gly Ser Val Met Leu Gly Phe Ala Arg Asp Gly Val Ala Gln 
            180                 185                 190         


Arg Leu Cys Gln Ile Gly Gln Phe Thr Val Pro Leu Gly Gly Gln Gln 
        195                 200                 205             


Val Pro Leu Arg Val Ser Pro Tyr Val Asn Gly Glu Ile Gln Lys Ala 
    210                 215                 220                 


Glu Ile Arg Ser Gln Pro Val Pro Arg Ser Val Leu Val Leu Asn Ile 
225                 230                 235                 240 


Pro Asp Ile Leu Asp Gly Pro Glu Leu His Asp Val Leu Glu Ile His 
                245                 250                 255     


Phe Gln Lys Pro Thr Arg Gly Gly Gly Glu Val Glu Ala Leu Thr Val 
            260                 265                 270         


Val Pro Gln Gly Gln Gln Gly Leu Ala Val Phe Thr Ser Glu Ser Gly 
        275                 280                 285             


<210>  5310
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFI44__Homo_sapiens__XP_011538818

<400>  5310

Met Ala Val Thr Thr Arg Leu Thr Trp Leu His Glu Lys Ile Leu Gln 
1               5                   10                  15      


Asn His Phe Gly Gly Lys Arg Leu Ser Leu Leu Tyr Lys Gly Ser Val 
            20                  25                  30          


His Gly Phe Arg Asn Gly Val Leu Leu Asp Arg Cys Cys Asn Gln Gly 
        35                  40                  45              


Pro Thr Leu Thr Val Ile Tyr Ser Glu Asp His Ile Ile Gly Ala Tyr 
    50                  55                  60                  


Ala Glu Glu Ser Tyr Gln Glu Gly Lys Tyr Ala Ser Ile Ile Leu Phe 
65                  70                  75                  80  


Ala Leu Gln Asp Thr Lys Ile Ser Glu Trp Lys Leu Gly Leu Cys Thr 
                85                  90                  95      


Pro Glu Thr Leu Phe Cys Cys Asp Val Thr Lys Tyr Asn Ser Pro Thr 
            100                 105                 110         


Asn Phe Gln Ile Asp Gly Arg Asn Arg Lys Val Ile Met Asp Leu Lys 
        115                 120                 125             


Thr Met Glu Asn Leu Gly Leu Ala Gln Asn Cys Thr Ile Ser Ile Gln 
    130                 135                 140                 


Asp Tyr Glu Val Phe Arg Cys Glu Asp Ser Leu Asp Glu Arg Lys Ile 
145                 150                 155                 160 


Lys Gly Val Ile Glu Leu Arg Lys Ser Leu Leu Ser Ala Leu Arg Thr 
                165                 170                 175     


Tyr Glu Pro Tyr Gly Ser Leu Val Gln Gln Ile Arg Ile Leu Leu Leu 
            180                 185                 190         


Gly Pro Ile Gly Ala Gly Lys Ser Ser Phe Phe Asn Ser Val Arg Ser 
        195                 200                 205             


Val Phe Gln Gly His Val Thr His Gln Ala Leu Val Gly Thr Asn Thr 
    210                 215                 220                 


Thr Gly Ile Ser Glu Lys Tyr Arg Thr Tyr Ser Ile Arg Asp Gly Lys 
225                 230                 235                 240 


Asp Gly Lys Tyr Leu Pro Phe Ile Leu Cys Asp Ser Leu Gly Leu Ser 
                245                 250                 255     


Glu Lys Glu Gly Gly Leu Cys Arg Asp Asp Ile Phe Tyr Ile Leu Asn 
            260                 265                 270         


Gly Asn Ile Arg Asp Arg Tyr Gln Phe Asn Pro Met Glu Ser Ile Lys 
        275                 280                 285             


Leu Asn His His Asp Tyr Ile Asp Ser Pro Ser Leu Lys Asp Arg Ile 
    290                 295                 300                 


His Cys Val Ala Phe Val Phe Asp Ala Ser Ser Ile Gln Tyr Phe Ser 
305                 310                 315                 320 


Ser Gln Met Ile Val Lys Ile Lys Arg Ile Arg Arg Glu Leu Val Asn 
                325                 330                 335     


Ala Gly Val Val His Val Ala Leu Leu Thr His Val Asp Ser Met Asp 
            340                 345                 350         


Leu Ile Thr Lys Gly Asp Leu Ile Glu Ile Glu Arg Cys Glu Pro Val 
        355                 360                 365             


Arg Ser Lys Leu Glu Glu Val Gln Arg Lys Leu Gly Phe Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ser Val Val Ser Asn Tyr Ser Ser Glu Trp Glu Leu Asp Pro 
385                 390                 395                 400 


Val Lys Asp Val Leu Ile Leu Ser Ala Leu Arg Arg Met Leu Trp Ala 
                405                 410                 415     


Ala Asp Asp Phe Leu Glu Asp Leu Pro Phe Glu Gln Ile Gly Arg Trp 
            420                 425                 430         


Phe Gly Gly Val Glu Ala Trp Lys Arg Ser Gly Asn Leu Arg Glu Glu 
        435                 440                 445             


Ile Ile Asn Cys Ala Gln Gly Lys Lys 
    450                 455         


<210>  5311
<211>  1025
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFIH1__Homo_sapiens__NP_071451

<400>  5311

Met Ser Asn Gly Tyr Ser Thr Asp Glu Asn Phe Arg Tyr Leu Ile Ser 
1               5                   10                  15      


Cys Phe Arg Ala Arg Val Lys Met Tyr Ile Gln Val Glu Pro Val Leu 
            20                  25                  30          


Asp Tyr Leu Thr Phe Leu Pro Ala Glu Val Lys Glu Gln Ile Gln Arg 
        35                  40                  45              


Thr Val Ala Thr Ser Gly Asn Met Gln Ala Val Glu Leu Leu Leu Ser 
    50                  55                  60                  


Thr Leu Glu Lys Gly Val Trp His Leu Gly Trp Thr Arg Glu Phe Val 
65                  70                  75                  80  


Glu Ala Leu Arg Arg Thr Gly Ser Pro Leu Ala Ala Arg Tyr Met Asn 
                85                  90                  95      


Pro Glu Leu Thr Asp Leu Pro Ser Pro Ser Phe Glu Asn Ala His Asp 
            100                 105                 110         


Glu Tyr Leu Gln Leu Leu Asn Leu Leu Gln Pro Thr Leu Val Asp Lys 
        115                 120                 125             


Leu Leu Val Arg Asp Val Leu Asp Lys Cys Met Glu Glu Glu Leu Leu 
    130                 135                 140                 


Thr Ile Glu Asp Arg Asn Arg Ile Ala Ala Ala Glu Asn Asn Gly Asn 
145                 150                 155                 160 


Glu Ser Gly Val Arg Glu Leu Leu Lys Arg Ile Val Gln Lys Glu Asn 
                165                 170                 175     


Trp Phe Ser Ala Phe Leu Asn Val Leu Arg Gln Thr Gly Asn Asn Glu 
            180                 185                 190         


Leu Val Gln Glu Leu Thr Gly Ser Asp Cys Ser Glu Ser Asn Ala Glu 
        195                 200                 205             


Ile Glu Asn Leu Ser Gln Val Asp Gly Pro Gln Val Glu Glu Gln Leu 
    210                 215                 220                 


Leu Ser Thr Thr Val Gln Pro Asn Leu Glu Lys Glu Val Trp Gly Met 
225                 230                 235                 240 


Glu Asn Asn Ser Ser Glu Ser Ser Phe Ala Asp Ser Ser Val Val Ser 
                245                 250                 255     


Glu Ser Asp Thr Ser Leu Ala Glu Gly Ser Val Ser Cys Leu Asp Glu 
            260                 265                 270         


Ser Leu Gly His Asn Ser Asn Met Gly Ser Asp Ser Gly Thr Met Gly 
        275                 280                 285             


Ser Asp Ser Asp Glu Glu Asn Val Ala Ala Arg Ala Ser Pro Glu Pro 
    290                 295                 300                 


Glu Leu Gln Leu Arg Pro Tyr Gln Met Glu Val Ala Gln Pro Ala Leu 
305                 310                 315                 320 


Glu Gly Lys Asn Ile Ile Ile Cys Leu Pro Thr Gly Ser Gly Lys Thr 
                325                 330                 335     


Arg Val Ala Val Tyr Ile Ala Lys Asp His Leu Asp Lys Lys Lys Lys 
            340                 345                 350         


Ala Ser Glu Pro Gly Lys Val Ile Val Leu Val Asn Lys Val Leu Leu 
        355                 360                 365             


Val Glu Gln Leu Phe Arg Lys Glu Phe Gln Pro Phe Leu Lys Lys Trp 
    370                 375                 380                 


Tyr Arg Val Ile Gly Leu Ser Gly Asp Thr Gln Leu Lys Ile Ser Phe 
385                 390                 395                 400 


Pro Glu Val Val Lys Ser Cys Asp Ile Ile Ile Ser Thr Ala Gln Ile 
                405                 410                 415     


Leu Glu Asn Ser Leu Leu Asn Leu Glu Asn Gly Glu Asp Ala Gly Val 
            420                 425                 430         


Gln Leu Ser Asp Phe Ser Leu Ile Ile Ile Asp Glu Cys His His Thr 
        435                 440                 445             


Asn Lys Glu Ala Val Tyr Asn Asn Ile Met Arg His Tyr Leu Met Gln 
    450                 455                 460                 


Lys Leu Lys Asn Asn Arg Leu Lys Lys Glu Asn Lys Pro Val Ile Pro 
465                 470                 475                 480 


Leu Pro Gln Ile Leu Gly Leu Thr Ala Ser Pro Gly Val Gly Gly Ala 
                485                 490                 495     


Thr Lys Gln Ala Lys Ala Glu Glu His Ile Leu Lys Leu Cys Ala Asn 
            500                 505                 510         


Leu Asp Ala Phe Thr Ile Lys Thr Val Lys Glu Asn Leu Asp Gln Leu 
        515                 520                 525             


Lys Asn Gln Ile Gln Glu Pro Cys Lys Lys Phe Ala Ile Ala Asp Ala 
    530                 535                 540                 


Thr Arg Glu Asp Pro Phe Lys Glu Lys Leu Leu Glu Ile Met Thr Arg 
545                 550                 555                 560 


Ile Gln Thr Tyr Cys Gln Met Ser Pro Met Ser Asp Phe Gly Thr Gln 
                565                 570                 575     


Pro Tyr Glu Gln Trp Ala Ile Gln Met Glu Lys Lys Ala Ala Lys Glu 
            580                 585                 590         


Gly Asn Arg Lys Glu Arg Val Cys Ala Glu His Leu Arg Lys Tyr Asn 
        595                 600                 605             


Glu Ala Leu Gln Ile Asn Asp Thr Ile Arg Met Ile Asp Ala Tyr Thr 
    610                 615                 620                 


His Leu Glu Thr Phe Tyr Asn Glu Glu Lys Asp Lys Lys Phe Ala Val 
625                 630                 635                 640 


Ile Glu Asp Asp Ser Asp Glu Gly Gly Asp Asp Glu Tyr Cys Asp Gly 
                645                 650                 655     


Asp Glu Asp Glu Asp Asp Leu Lys Lys Pro Leu Lys Leu Asp Glu Thr 
            660                 665                 670         


Asp Arg Phe Leu Met Thr Leu Phe Phe Glu Asn Asn Lys Met Leu Lys 
        675                 680                 685             


Arg Leu Ala Glu Asn Pro Glu Tyr Glu Asn Glu Lys Leu Thr Lys Leu 
    690                 695                 700                 


Arg Asn Thr Ile Met Glu Gln Tyr Thr Arg Thr Glu Glu Ser Ala Arg 
705                 710                 715                 720 


Gly Ile Ile Phe Thr Lys Thr Arg Gln Ser Ala Tyr Ala Leu Ser Gln 
                725                 730                 735     


Trp Ile Thr Glu Asn Glu Lys Phe Ala Glu Val Gly Val Lys Ala His 
            740                 745                 750         


His Leu Ile Gly Ala Gly His Ser Ser Glu Phe Lys Pro Met Thr Gln 
        755                 760                 765             


Asn Glu Gln Lys Glu Val Ile Ser Lys Phe Arg Thr Gly Lys Ile Asn 
    770                 775                 780                 


Leu Leu Ile Ala Thr Thr Val Ala Glu Glu Gly Leu Asp Ile Lys Glu 
785                 790                 795                 800 


Cys Asn Ile Val Ile Arg Tyr Gly Leu Val Thr Asn Glu Ile Ala Met 
                805                 810                 815     


Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Glu Ser Thr Tyr Val Leu 
            820                 825                 830         


Val Ala His Ser Gly Ser Gly Val Ile Glu His Glu Thr Val Asn Asp 
        835                 840                 845             


Phe Arg Glu Lys Met Met Tyr Lys Ala Ile His Cys Val Gln Asn Met 
    850                 855                 860                 


Lys Pro Glu Glu Tyr Ala His Lys Ile Leu Glu Leu Gln Met Gln Ser 
865                 870                 875                 880 


Ile Met Glu Lys Lys Met Lys Thr Lys Arg Asn Ile Ala Lys His Tyr 
                885                 890                 895     


Lys Asn Asn Pro Ser Leu Ile Thr Phe Leu Cys Lys Asn Cys Ser Val 
            900                 905                 910         


Leu Ala Cys Ser Gly Glu Asp Ile His Val Ile Glu Lys Met His His 
        915                 920                 925             


Val Asn Met Thr Pro Glu Phe Lys Glu Leu Tyr Ile Val Arg Glu Asn 
    930                 935                 940                 


Lys Ala Leu Gln Lys Lys Cys Ala Asp Tyr Gln Ile Asn Gly Glu Ile 
945                 950                 955                 960 


Ile Cys Lys Cys Gly Gln Ala Trp Gly Thr Met Met Val His Lys Gly 
                965                 970                 975     


Leu Asp Leu Pro Cys Leu Lys Ile Arg Asn Phe Val Val Val Phe Lys 
            980                 985                 990         


Asn Asn Ser Thr Lys Lys Gln Tyr  Lys Lys Trp Val Glu  Leu Pro Ile 
        995                 1000                 1005             


Thr Phe  Pro Asn Leu Asp Tyr  Ser Glu Cys Cys Leu  Phe Ser Asp 
    1010                 1015                 1020             


Glu Asp  
    1025 


<210>  5312
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFIT1__Homo_sapiens__NP_001257858

<400>  5312

Met Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp 
1               5                   10                  15      


Thr Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His 
            20                  25                  30          


Leu Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu 
        35                  40                  45              


Asn Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu 
    50                  55                  60                  


Val Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu 
65                  70                  75                  80  


Ala Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys 
                85                  90                  95      


Leu Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys 
            100                 105                 110         


Glu Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg 
        115                 120                 125             


Ala Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro 
    130                 135                 140                 


Glu Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe 
145                 150                 155                 160 


Lys Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg 
                165                 170                 175     


Gln Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu 
            180                 185                 190         


Ala Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr 
        195                 200                 205             


Ile Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg 
    210                 215                 220                 


Tyr Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu 
225                 230                 235                 240 


Glu Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu 
                245                 250                 255     


His His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys 
            260                 265                 270         


Glu Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp 
        275                 280                 285             


Lys Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys 
    290                 295                 300                 


Lys Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile 
305                 310                 315                 320 


Glu Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu 
                325                 330                 335     


Cys Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His 
            340                 345                 350         


Tyr Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile 
        355                 360                 365             


Ile His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg 
    370                 375                 380                 


Asp Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg 
385                 390                 395                 400 


Arg Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr 
                405                 410                 415     


Lys Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala 
            420                 425                 430         


Leu Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
        435                 440                 445         


<210>  5313
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFIT2__Homo_sapiens__NP_001538

<400>  5313

Met Ser Glu Asn Asn Lys Asn Ser Leu Glu Ser Ser Leu Arg Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Met Glu Gly Glu Asn Ser Leu Asp 
            20                  25                  30          


Asp Phe Glu Asp Lys Val Phe Tyr Arg Thr Glu Phe Gln Asn Arg Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Cys Asn Leu Leu Ala Tyr Leu Lys His Leu Lys 
    50                  55                  60                  


Gly Gln Asn Glu Ala Ala Leu Glu Cys Leu Arg Lys Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Met Gly Arg Leu Ser Asp 
            100                 105                 110         


Val Gln Ile Tyr Val Asp Lys Val Lys His Val Cys Glu Lys Phe Ser 
        115                 120                 125             


Ser Pro Tyr Arg Ile Glu Ser Pro Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Arg Leu Lys Cys Gly Gly Asn Gln Asn Glu Arg Ala Lys Val Cys 
145                 150                 155                 160 


Phe Glu Lys Ala Leu Glu Lys Lys Pro Lys Asn Pro Glu Phe Thr Ser 
                165                 170                 175     


Gly Leu Ala Ile Ala Ser Tyr Arg Leu Asp Asn Trp Pro Pro Ser Gln 
            180                 185                 190         


Asn Ala Ile Asp Pro Leu Arg Gln Ala Ile Arg Leu Asn Pro Asp Asn 
        195                 200                 205             


Gln Tyr Leu Lys Val Leu Leu Ala Leu Lys Leu His Lys Met Arg Glu 
    210                 215                 220                 


Glu Gly Glu Glu Glu Gly Glu Gly Glu Lys Leu Val Glu Glu Ala Leu 
225                 230                 235                 240 


Glu Lys Ala Pro Gly Val Thr Asp Val Leu Arg Ser Ala Ala Lys Phe 
                245                 250                 255     


Tyr Arg Arg Lys Asp Glu Pro Asp Lys Ala Ile Glu Leu Leu Lys Lys 
            260                 265                 270         


Ala Leu Glu Tyr Ile Pro Asn Asn Ala Tyr Leu His Cys Gln Ile Gly 
        275                 280                 285             


Cys Cys Tyr Arg Ala Lys Val Phe Gln Val Met Asn Leu Arg Glu Asn 
    290                 295                 300                 


Gly Met Tyr Gly Lys Arg Lys Leu Leu Glu Leu Ile Gly His Ala Val 
305                 310                 315                 320 


Ala His Leu Lys Lys Ala Asp Glu Ala Asn Asp Asn Leu Phe Arg Val 
                325                 330                 335     


Cys Ser Ile Leu Ala Ser Leu His Ala Leu Ala Asp Gln Tyr Glu Asp 
            340                 345                 350         


Ala Glu Tyr Tyr Phe Gln Lys Glu Phe Ser Lys Glu Leu Thr Pro Val 
        355                 360                 365             


Ala Lys Gln Leu Leu His Leu Arg Tyr Gly Asn Phe Gln Leu Tyr Gln 
    370                 375                 380                 


Met Lys Cys Glu Asp Lys Ala Ile His His Phe Ile Glu Gly Val Lys 
385                 390                 395                 400 


Ile Asn Gln Lys Ser Arg Glu Lys Glu Lys Met Lys Asp Lys Leu Gln 
                405                 410                 415     


Lys Ile Ala Lys Met Arg Leu Ser Lys Asn Gly Ala Asp Ser Glu Ala 
            420                 425                 430         


Leu His Val Leu Ala Phe Leu Gln Glu Leu Asn Glu Lys Met Gln Gln 
        435                 440                 445             


Ala Asp Glu Asp Ser Glu Arg Gly Leu Glu Ser Gly Ser Leu Ile Pro 
    450                 455                 460                 


Ser Ala Ser Ser Trp Asn Gly Glu 
465                 470         


<210>  5314
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFIT3__Homo_sapiens__NP_001276687

<400>  5314

Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp Gly Asn Asn Glu 
1               5                   10                  15      


Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu Ile Gln Gln Glu 
            20                  25                  30          


His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr Trp Gly Asn Tyr 
        35                  40                  45              


Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp Ala Gln Ile Tyr 
    50                  55                  60                  


Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser Asn Pro Tyr Ser 
65                  70                  75                  80  


Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp Thr Gln Leu Lys 
                85                  90                  95      


Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu Lys Ala Leu Glu 
            100                 105                 110         


Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu Ala Ile Ala Met 
        115                 120                 125             


Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser Thr Asp Val Leu 
    130                 135                 140                 


Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr Val Lys Val Leu 
145                 150                 155                 160 


Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala Glu Gly Glu Gln 
                165                 170                 175     


Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln Thr Asp Val Leu 
            180                 185                 190         


Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp Leu Asp Lys Ala 
        195                 200                 205             


Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro Asn Asn Gly Tyr 
    210                 215                 220                 


Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys Val Arg Gln Met 
225                 230                 235                 240 


Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys Glu Met Ile Glu 
                245                 250                 255     


Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys Ala Leu Glu Lys 
            260                 265                 270         


Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala Glu Phe Leu Glu 
        275                 280                 285             


Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val Pro Asp Ala Glu 
    290                 295                 300                 


Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln Lys Tyr Asn Gly 
305                 310                 315                 320 


Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu Gly Leu Ser Ile 
                325                 330                 335     


Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp Gln Pro Gln Asn 
            340                 345                 350         


Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn Tyr Trp Tyr Leu 
        355                 360                 365             


Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu Gln Ala Ala Lys 
    370                 375                 380                 


Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp Ala Pro Ser Gly 
385                 390                 395                 400 


Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu Asp Gly Ser Glu 
                405                 410                 415     


Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg Glu Leu Leu Ser 
            420                 425                 430         


Asn Ser Glu Gln Leu Asn 
        435             


<210>  5315
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFIT5__Homo_sapiens__NP_036552

<400>  5315

Met Ser Glu Ile Arg Lys Asp Thr Leu Lys Ala Ile Leu Leu Glu Leu 
1               5                   10                  15      


Glu Cys His Phe Thr Trp Asn Leu Leu Lys Glu Asp Ile Asp Leu Phe 
            20                  25                  30          


Glu Val Glu Asp Thr Ile Gly Gln Gln Leu Glu Phe Leu Thr Thr Lys 
        35                  40                  45              


Ser Arg Leu Ala Leu Tyr Asn Leu Leu Ala Tyr Val Lys His Leu Lys 
    50                  55                  60                  


Gly Gln Asn Lys Asp Ala Leu Glu Cys Leu Glu Gln Ala Glu Glu Ile 
65                  70                  75                  80  


Ile Gln Gln Glu His Ser Asp Lys Glu Glu Val Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Met Asp Gln Leu Glu Glu 
            100                 105                 110         


Ala Gln Lys Tyr Thr Gly Lys Ile Gly Asn Val Cys Lys Lys Leu Ser 
        115                 120                 125             


Ser Pro Ser Asn Tyr Lys Leu Glu Cys Pro Glu Thr Asp Cys Glu Lys 
    130                 135                 140                 


Gly Trp Ala Leu Leu Lys Phe Gly Gly Lys Tyr Tyr Gln Lys Ala Lys 
145                 150                 155                 160 


Ala Ala Phe Glu Lys Ala Leu Glu Val Glu Pro Asp Asn Pro Glu Phe 
                165                 170                 175     


Asn Ile Gly Tyr Ala Ile Thr Val Tyr Arg Leu Asp Asp Ser Asp Arg 
            180                 185                 190         


Glu Gly Ser Val Lys Ser Phe Ser Leu Gly Pro Leu Arg Lys Ala Val 
        195                 200                 205             


Thr Leu Asn Pro Asp Asn Ser Tyr Ile Lys Val Phe Leu Ala Leu Lys 
    210                 215                 220                 


Leu Gln Asp Val His Ala Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu 
225                 230                 235                 240 


Ile Leu Asp Gln Ile Ser Ser Gln Pro Tyr Val Leu Arg Tyr Ala Ala 
                245                 250                 255     


Lys Phe Tyr Arg Arg Lys Asn Ser Trp Asn Lys Ala Leu Glu Leu Leu 
            260                 265                 270         


Lys Lys Ala Leu Glu Val Thr Pro Thr Ser Ser Phe Leu His His Gln 
        275                 280                 285             


Met Gly Leu Cys Tyr Arg Ala Gln Met Ile Gln Ile Lys Lys Ala Thr 
    290                 295                 300                 


His Asn Arg Pro Lys Gly Lys Asp Lys Leu Lys Val Asp Glu Leu Ile 
305                 310                 315                 320 


Ser Ser Ala Ile Phe His Phe Lys Ala Ala Met Glu Arg Asp Ser Met 
                325                 330                 335     


Phe Ala Phe Ala Tyr Thr Asp Leu Ala Asn Met Tyr Ala Glu Gly Gly 
            340                 345                 350         


Gln Tyr Ser Asn Ala Glu Asp Ile Phe Arg Lys Ala Leu Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Asp Asp His Lys His Gln Ile His Tyr His Tyr Gly Arg 
    370                 375                 380                 


Phe Gln Glu Phe His Arg Lys Ser Glu Asn Thr Ala Ile His His Tyr 
385                 390                 395                 400 


Leu Glu Ala Leu Lys Val Lys Asp Arg Ser Pro Leu Arg Thr Lys Leu 
                405                 410                 415     


Thr Ser Ala Leu Lys Lys Leu Ser Thr Lys Arg Leu Cys His Asn Ala 
            420                 425                 430         


Leu Asp Val Gln Ser Leu Ser Ala Leu Gly Phe Val Tyr Lys Leu Glu 
        435                 440                 445             


Gly Glu Lys Arg Gln Ala Ala Glu Tyr Tyr Glu Lys Ala Gln Lys Ile 
    450                 455                 460                 


Asp Pro Glu Asn Ala Glu Phe Leu Thr Ala Leu Cys Glu Leu Arg Leu 
465                 470                 475                 480 


Ser Ile 
        


<210>  5316
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFITM1__Homo_sapiens__NP_003632

<400>  5316

Met His Lys Glu Glu His Glu Val Ala Val Leu Gly Ala Pro Pro Ser 
1               5                   10                  15      


Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser 
            20                  25                  30          


Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn 
        35                  40                  45              


Trp Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg 
    50                  55                  60                  


Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser 
65                  70                  75                  80  


Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met 
                85                  90                  95      


Thr Ile Gly Phe Ile Leu Leu Leu Val Phe Gly Ser Val Thr Val Tyr 
            100                 105                 110         


His Ile Met Leu Gln Ile Ile Gln Glu Lys Arg Gly Tyr 
        115                 120                 125 


<210>  5317
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFITM2__Homo_sapiens__NP_006426

<400>  5317

Met Asn His Ile Val Gln Thr Phe Ser Pro Val Asn Ser Gly Gln Pro 
1               5                   10                  15      


Pro Asn Tyr Glu Met Leu Lys Glu Glu Gln Glu Val Ala Met Leu Gly 
            20                  25                  30          


Val Pro His Asn Pro Ala Pro Pro Met Ser Thr Val Ile His Ile Arg 
        35                  40                  45              


Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr 
    50                  55                  60                  


Leu Phe Met Asn Thr Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser 
65                  70                  75                  80  


Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln 
                85                  90                  95      


Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu 
            100                 105                 110         


Gly Ile Phe Met Thr Ile Leu Leu Ile Ile Ile Pro Val Leu Val Val 
        115                 120                 125             


Gln Ala Gln Arg 
    130         


<210>  5318
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFITM3__Homo_sapiens__NP_066362

<400>  5318

Met Asn His Thr Val Gln Thr Phe Phe Ser Pro Val Asn Ser Gly Gln 
1               5                   10                  15      


Pro Pro Asn Tyr Glu Met Leu Lys Glu Glu His Glu Val Ala Val Leu 
            20                  25                  30          


Gly Ala Pro His Asn Pro Ala Pro Pro Thr Ser Thr Val Ile His Ile 
        35                  40                  45              


Arg Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn 
    50                  55                  60                  


Thr Leu Phe Met Asn Pro Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr 
65                  70                  75                  80  


Ser Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala 
                85                  90                  95      


Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile 
            100                 105                 110         


Leu Gly Ile Leu Met Thr Ile Leu Leu Ile Val Ile Pro Val Leu Ile 
        115                 120                 125             


Phe Gln Ala Tyr Gly 
    130             


<210>  5319
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFITM5__Homo_sapiens__NP_001020466

<400>  5319

Met Asp Thr Ala Tyr Pro Arg Glu Asp Thr Arg Ala Pro Thr Pro Ser 
1               5                   10                  15      


Lys Ala Gly Ala His Thr Ala Leu Thr Leu Gly Ala Pro His Pro Pro 
            20                  25                  30          


Pro Arg Asp His Leu Ile Trp Ser Val Phe Ser Thr Leu Tyr Leu Asn 
        35                  40                  45              


Leu Cys Cys Leu Gly Phe Leu Ala Leu Ala Tyr Ser Ile Lys Ala Arg 
    50                  55                  60                  


Asp Gln Lys Val Val Gly Asp Leu Glu Ala Ala Arg Arg Phe Gly Ser 
65                  70                  75                  80  


Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu Val Pro 
                85                  90                  95      


Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His Leu Ala 
            100                 105                 110         


Arg Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe Asp Asp 
        115                 120                 125             


Ala Asp Tyr Asp 
    130         


<210>  5320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA10__Homo_sapiens__NP_002162

<400>  5320

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Gly Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Ile Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Ile Glu Arg Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  5321
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA13__Homo_sapiens__NP_008831

<400>  5321

Met Met Ala Ser Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser 
1               5                   10                  15      


Cys Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser 
            20                  25                  30          


Leu Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile 
        35                  40                  45              


Ser Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln 
    50                  55                  60                  


Glu Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val 
65                  70                  75                  80  


Leu His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp 
                85                  90                  95      


Ser Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu 
        115                 120                 125             


Arg Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val 
    130                 135                 140                 


Lys Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr 
145                 150                 155                 160 


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu 
                165                 170                 175     


Ser Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 190 


<210>  5322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA14__Homo_sapiens__NP_002163

<400>  5322

Met Ala Leu Pro Phe Ala Leu Met Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu 
            20                  25                  30          


Asn Asn Arg Arg Thr Leu Met Leu Met Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Met Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asn Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Met Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  5323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA16__Homo_sapiens__NP_002164

<400>  5323

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  5324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA17__Homo_sapiens__NP_067091

<400>  5324

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Leu Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asn Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Met Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Ile Leu Arg Arg Lys Asp 
            180                 185                 


<210>  5325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA1__Homo_sapiens__NP_076918

<400>  5325

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  5326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA21__Homo_sapiens__NP_002166

<400>  5326

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Asn Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Lys Ile Phe Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  5327
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA2__Homo_sapiens__NP_000596

<400>  5327

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  5328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA4__Homo_sapiens__NP_066546

<400>  5328

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  5329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA5__Homo_sapiens__NP_002160

<400>  5329

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  5330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA6__Homo_sapiens__NP_066282

<400>  5330

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val Trp 
        115                 120                 125             


Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  5331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA7__Homo_sapiens__NP_066401

<400>  5331

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Arg Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Glu Phe Arg Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Phe Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Lys Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  5332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNA8__Homo_sapiens__NP_002161

<400>  5332

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Asp Lys Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Leu Asp Glu Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu 
            100                 105                 110         


Asp Gln Gln Leu Asn Asp Leu Glu Ser Cys Val Met Gln Glu Val Gly 
        115                 120                 125             


Val Ile Glu Ser Pro Leu Met Tyr Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Ser Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ile Asn Leu Gln Lys Arg Leu Lys Ser Lys Glu 
            180                 185                 


<210>  5333
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR1__Homo_sapiens__NP_000620

<400>  5333

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe 
        435                 440                 445             


Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile 
    450                 455                 460                 


Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
465                 470                 475                 480 


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
                485                 490                 495     


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala 
            500                 505                 510         


Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser 
        515                 520                 525             


Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser 
    530                 535                 540                 


Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val 
545                 550                 555         


<210>  5334
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNAR2__Homo_sapiens__NP_997467

<400>  5334

Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val 
1               5                   10                  15      


Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro 
            20                  25                  30          


Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe 
        35                  40                  45              


Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr 
    50                  55                  60                  


His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys 
65                  70                  75                  80  


Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr 
                85                  90                  95      


Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly 
            100                 105                 110         


Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu 
        115                 120                 125             


Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu 
145                 150                 155                 160 


Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly 
                165                 170                 175     


Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn 
            180                 185                 190         


Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val 
        195                 200                 205             


Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val 
                245                 250                 255     


Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu 
            260                 265                 270         


Arg Asn Ser Leu Pro Lys Val Leu Arg Gln Gly Leu Ala Lys Gly Trp 
        275                 280                 285             


Asn Ala Val Ala Ile His Arg Cys Ser His Asn Ala Leu Gln Ser Glu 
    290                 295                 300                 


Thr Pro Glu Leu Lys Gln Ser Ser Cys Leu Ser Phe Pro Ser Ser Trp 
305                 310                 315                 320 


Asp Tyr Lys Arg Ala Ser Leu Cys Pro Ser Asp 
                325                 330     


<210>  5335
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNB1__Homo_sapiens__NP_002167

<400>  5335

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  5336
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNE__Homo_sapiens__NP_795372

<400>  5336

Met Ile Ile Lys His Phe Phe Gly Thr Val Leu Val Leu Leu Ala Ser 
1               5                   10                  15      


Thr Thr Ile Phe Ser Leu Asp Leu Lys Leu Ile Ile Phe Gln Gln Arg 
            20                  25                  30          


Gln Val Asn Gln Glu Ser Leu Lys Leu Leu Asn Lys Leu Gln Thr Leu 
        35                  40                  45              


Ser Ile Gln Gln Cys Leu Pro His Arg Lys Asn Phe Leu Leu Pro Gln 
    50                  55                  60                  


Lys Ser Leu Ser Pro Gln Gln Tyr Gln Lys Gly His Thr Leu Ala Ile 
65                  70                  75                  80  


Leu His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe Arg Ala Asn Ile 
                85                  90                  95      


Ser Leu Asp Gly Trp Glu Glu Asn His Thr Glu Lys Phe Leu Ile Gln 
            100                 105                 110         


Leu His Gln Gln Leu Glu Tyr Leu Glu Ala Leu Met Gly Leu Glu Ala 
        115                 120                 125             


Glu Lys Leu Ser Gly Thr Leu Gly Ser Asp Asn Leu Arg Leu Gln Val 
    130                 135                 140                 


Lys Met Tyr Phe Arg Arg Ile His Asp Tyr Leu Glu Asn Gln Asp Tyr 
145                 150                 155                 160 


Ser Thr Cys Ala Trp Ala Ile Val Gln Val Glu Ile Ser Arg Cys Leu 
                165                 170                 175     


Phe Phe Val Phe Ser Leu Thr Glu Lys Leu Ser Lys Gln Gly Arg Pro 
            180                 185                 190         


Leu Asn Asp Met Lys Gln Glu Leu Thr Thr Glu Phe Arg Ser Pro Arg 
        195                 200                 205             


<210>  5337
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNG__Homo_sapiens__NP_000610

<400>  5337

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  5338
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNGR1__Homo_sapiens__NP_000407

<400>  5338

Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg 
1               5                   10                  15      


Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro 
            20                  25                  30          


Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp 
        35                  40                  45              


Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys 
    50                  55                  60                  


Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile 
65                  70                  75                  80  


Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn 
                85                  90                  95      


Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala 
            100                 105                 110         


Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly 
        115                 120                 125             


Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp 
    130                 135                 140                 


Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp 
145                 150                 155                 160 


Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val 
                165                 170                 175     


Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu 
            180                 185                 190         


Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser 
        195                 200                 205             


Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp 
    210                 215                 220                 


Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn 
225                 230                 235                 240 


Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu 
                245                 250                 255     


Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys 
            260                 265                 270         


Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile 
        275                 280                 285             


Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val 
305                 310                 315                 320 


Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr 
                325                 330                 335     


Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile 
            340                 345                 350         


Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly 
        355                 360                 365             


Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser 
    370                 375                 380                 


Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg 
385                 390                 395                 400 


Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser 
                405                 410                 415     


Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro 
            420                 425                 430         


Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val 
        435                 440                 445             


Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val 
    450                 455                 460                 


Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg 
465                 470                 475                 480 


Pro Thr Glu Asp Ser Lys Glu Phe Ser 
                485                 


<210>  5339
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNGR2__Homo_sapiens__NP_005525

<400>  5339

Met Arg Pro Thr Leu Leu Trp Ser Leu Leu Leu Leu Leu Gly Val Phe 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Pro Pro Asp Pro Leu Ser Gln Leu Pro Ala 
            20                  25                  30          


Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala Glu Gln Val Leu Ser 
        35                  40                  45              


Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg Pro Val Val Tyr Gln 
    50                  55                  60                  


Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe Thr Ala Asp Ile Met 
65                  70                  75                  80  


Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala Thr Glu Cys Asp Phe 
                85                  90                  95      


Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met Asp Phe Asn Val Thr 
            100                 105                 110         


Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His Ser Ala Trp Val Thr 
        115                 120                 125             


Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr Val Gly Pro Pro Glu 
    130                 135                 140                 


Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu Ile Ile Arg Phe Ser 
145                 150                 155                 160 


Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala Phe Phe Cys Tyr Tyr 
                165                 170                 175     


Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln Val Lys Gly Pro Phe 
            180                 185                 190         


Arg Ser Asn Ser Ile Ser Leu Asp Asn Leu Lys Pro Ser Arg Val Tyr 
        195                 200                 205             


Cys Leu Gln Val Gln Ala Gln Leu Leu Trp Asn Lys Ser Asn Ile Phe 
    210                 215                 220                 


Arg Val Gly His Leu Ser Asn Ile Ser Cys Tyr Glu Thr Met Ala Asp 
225                 230                 235                 240 


Ala Ser Thr Glu Leu Gln Gln Val Ile Leu Ile Ser Val Gly Thr Phe 
                245                 250                 255     


Ser Leu Leu Ser Val Leu Ala Gly Ala Cys Phe Phe Leu Val Leu Lys 
            260                 265                 270         


Tyr Arg Gly Leu Ile Lys Tyr Trp Phe His Thr Pro Pro Ser Ile Pro 
        275                 280                 285             


Leu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Thr Gln Pro Ile Leu Glu 
    290                 295                 300                 


Ala Leu Asp Lys Asp Ser Ser Pro Lys Asp Asp Val Trp Asp Ser Val 
305                 310                 315                 320 


Ser Ile Ile Ser Phe Pro Glu Lys Glu Gln Glu Asp Val Leu Gln Thr 
                325                 330                 335     


Leu 
    


<210>  5340
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNK__Homo_sapiens__NP_064509

<400>  5340

Met Ser Thr Lys Pro Asp Met Ile Gln Lys Cys Leu Trp Leu Glu Ile 
1               5                   10                  15      


Leu Met Gly Ile Phe Ile Ala Gly Thr Leu Ser Leu Asp Cys Asn Leu 
            20                  25                  30          


Leu Asn Val His Leu Arg Arg Val Thr Trp Gln Asn Leu Arg His Leu 
        35                  40                  45              


Ser Ser Met Ser Asn Ser Phe Pro Val Glu Cys Leu Arg Glu Asn Ile 
    50                  55                  60                  


Ala Phe Glu Leu Pro Gln Glu Phe Leu Gln Tyr Thr Gln Pro Met Lys 
65                  70                  75                  80  


Arg Asp Ile Lys Lys Ala Phe Tyr Glu Met Ser Leu Gln Ala Phe Asn 
                85                  90                  95      


Ile Phe Ser Gln His Thr Phe Lys Tyr Trp Lys Glu Arg His Leu Lys 
            100                 105                 110         


Gln Ile Gln Ile Gly Leu Asp Gln Gln Ala Glu Tyr Leu Asn Gln Cys 
        115                 120                 125             


Leu Glu Glu Asp Lys Asn Glu Asn Glu Asp Met Lys Glu Met Lys Glu 
    130                 135                 140                 


Asn Glu Met Lys Pro Ser Glu Ala Arg Val Pro Gln Leu Ser Ser Leu 
145                 150                 155                 160 


Glu Leu Arg Arg Tyr Phe His Arg Ile Asp Asn Phe Leu Lys Glu Lys 
                165                 170                 175     


Lys Tyr Ser Asp Cys Ala Trp Glu Ile Val Arg Val Glu Ile Arg Arg 
            180                 185                 190         


Cys Leu Tyr Tyr Phe Tyr Lys Phe Thr Ala Leu Phe Arg Arg Lys 
        195                 200                 205         


<210>  5341
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNL1__Homo_sapiens__NP_742152

<400>  5341

Met Ala Ala Ala Trp Thr Val Val Leu Val Thr Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys 
            20                  25                  30          


Gly Cys His Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala 
        35                  40                  45              


Ser Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys 
    50                  55                  60                  


Asn Trp Ser Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg 
65                  70                  75                  80  


Leu Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala 
                85                  90                  95      


Leu Thr Leu Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp 
            100                 105                 110         


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
        115                 120                 125             


Gln Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly 
    130                 135                 140                 


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Ala Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
                165                 170                 175     


Leu Thr Arg Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg 
            180                 185                 190         


Thr Ser Thr His Pro Glu Ser Thr 
        195                 200 


<210>  5342
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNL2__Homo_sapiens__XP_011525058

<400>  5342

Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210>  5343
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNL3__Homo_sapiens__NP_742151

<400>  5343

Met Thr Gly Asp Cys Met Pro Val Leu Val Leu Met Ala Ala Val Leu 
1               5                   10                  15      


Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu Arg Gly Ala Leu Pro 
            20                  25                  30          


Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln 
        35                  40                  45              


Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu 
    50                  55                  60                  


Leu Leu Lys Asp Cys Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala 
                85                  90                  95      


Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp 
            100                 105                 110         


Pro Ala Leu Gly Asp Val Leu Asp Gln Pro Leu His Thr Leu His His 
        115                 120                 125             


Ile Leu Ser Gln Leu Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly 
    130                 135                 140                 


Pro Arg Thr Arg Gly Arg Leu His His Trp Leu His Arg Leu Gln Glu 
145                 150                 155                 160 


Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe 
                165                 170                 175     


Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly 
            180                 185                 190         


Asp Leu Cys Val 
        195     


<210>  5344
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFNW1__Homo_sapiens__NP_002168

<400>  5344

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  5345
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFRD1__Homo_sapiens__NP_001007246

<400>  5345

Met Pro Lys Asn Lys Lys Arg Asn Thr Pro His Arg Gly Ser Ser Ala 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Ala Ala Ala Ala Thr Ala Ala Thr Ala Gly 
            20                  25                  30          


Gly Gln His Arg Asn Val Gln Pro Phe Ser Asp Glu Asp Ala Ser Ile 
        35                  40                  45              


Glu Thr Met Ser His Cys Ser Gly Tyr Ser Asp Pro Ser Ser Phe Ala 
    50                  55                  60                  


Glu Asp Gly Pro Glu Val Leu Asp Glu Glu Gly Thr Gln Glu Asp Leu 
65                  70                  75                  80  


Glu Tyr Lys Leu Lys Gly Leu Ile Asp Leu Thr Leu Asp Lys Ser Ala 
                85                  90                  95      


Lys Thr Arg Gln Ala Ala Leu Glu Gly Ile Lys Asn Ala Leu Ala Ser 
            100                 105                 110         


Lys Met Leu Tyr Glu Phe Ile Leu Glu Arg Arg Met Thr Leu Thr Asp 
        115                 120                 125             


Ser Ile Glu Arg Cys Leu Lys Lys Gly Lys Ser Asp Glu Gln Arg Ala 
    130                 135                 140                 


Ala Ala Ala Leu Ala Ser Val Leu Cys Ile Gln Leu Gly Pro Gly Ile 
145                 150                 155                 160 


Glu Ser Glu Glu Ile Leu Lys Thr Leu Gly Pro Ile Leu Lys Lys Ile 
                165                 170                 175     


Ile Cys Asp Gly Ser Ala Ser Met Gln Ala Arg Gln Thr Cys Ala Thr 
            180                 185                 190         


Cys Phe Gly Val Cys Cys Phe Ile Ala Thr Asp Asp Ile Thr Glu Leu 
        195                 200                 205             


Tyr Ser Thr Leu Glu Cys Leu Glu Asn Ile Phe Thr Lys Ser Tyr Leu 
    210                 215                 220                 


Lys Glu Lys Asp Thr Thr Val Ile Cys Ser Thr Pro Asn Thr Val Leu 
225                 230                 235                 240 


His Ile Ser Ser Leu Leu Ala Trp Thr Leu Leu Leu Thr Ile Cys Pro 
                245                 250                 255     


Ile Asn Glu Val Lys Lys Lys Leu Glu Met His Phe His Lys Leu Pro 
            260                 265                 270         


Ser Leu Leu Ser Cys Asp Asp Val Asn Met Arg Ile Ala Ala Gly Glu 
        275                 280                 285             


Ser Leu Ala Leu Leu Phe Glu Leu Ala Arg Gly Ile Glu Ser Asp Phe 
    290                 295                 300                 


Phe Tyr Glu Asp Met Glu Ser Leu Thr Gln Met Leu Arg Ala Leu Ala 
305                 310                 315                 320 


Thr Asp Gly Asn Lys His Arg Ala Lys Val Asp Lys Arg Lys Gln Arg 
                325                 330                 335     


Ser Val Phe Arg Asp Val Leu Arg Ala Val Glu Glu Arg Asp Phe Pro 
            340                 345                 350         


Thr Glu Thr Ile Lys Phe Gly Pro Glu Arg Met Tyr Ile Asp Cys Trp 
        355                 360                 365             


Val Lys Lys His Thr Tyr Asp Thr Phe Lys Glu Val Leu Gly Ser Gly 
    370                 375                 380                 


Met Gln Tyr His Leu Gln Ser Asn Glu Phe Leu Arg Asn Val Phe Glu 
385                 390                 395                 400 


Leu Gly Pro Pro Val Met Leu Asp Ala Ala Thr Leu Lys Thr Met Lys 
                405                 410                 415     


Ile Ser Arg Phe Glu Arg His Leu Tyr Asn Ser Ala Ala Phe Lys Ala 
            420                 425                 430         


Arg Thr Lys Ala Arg Ser Lys Cys Arg Asp Lys Arg Ala Asp Val Gly 
        435                 440                 445             


Glu Phe Phe 
    450     


<210>  5346
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT122__Homo_sapiens__NP_001267475

<400>  5346

Met Phe Asn Gly Ile Ile Ser Ile Arg Asn Lys Asn Gly Glu Glu Lys 
1               5                   10                  15      


Val Lys Ile Glu Arg Pro Gly Gly Ser Leu Ser Pro Ile Trp Ser Ile 
            20                  25                  30          


Cys Trp Asn Pro Ser Arg Glu Glu Arg Asn Asp Ile Leu Ala Val Ala 
        35                  40                  45              


Asp Trp Gly Gln Lys Val Ser Phe Tyr Gln Leu Ser Gly Lys Gln Ile 
    50                  55                  60                  


Gly Lys Asp Arg Ala Leu Asn Phe Asp Pro Cys Cys Ile Ser Tyr Phe 
65                  70                  75                  80  


Thr Lys Gly Glu Tyr Ile Leu Leu Gly Gly Ser Asp Lys Gln Val Ser 
                85                  90                  95      


Leu Phe Thr Lys Asp Gly Val Arg Leu Gly Thr Val Gly Glu Gln Asn 
            100                 105                 110         


Ser Trp Val Trp Thr Cys Gln Ala Lys Pro Asp Ser Asn Tyr Val Val 
        115                 120                 125             


Val Gly Cys Gln Asp Gly Thr Ile Ser Phe Tyr Gln Leu Ile Phe Ser 
    130                 135                 140                 


Thr Val His Gly Leu Tyr Lys Asp Arg Tyr Ala Tyr Arg Asp Ser Met 
145                 150                 155                 160 


Thr Asp Val Ile Val Gln His Leu Ile Thr Glu Gln Lys Val Arg Ile 
                165                 170                 175     


Lys Cys Lys Glu Leu Val Lys Lys Ile Ala Ile Tyr Arg Asn Arg Leu 
            180                 185                 190         


Ala Ile Gln Leu Pro Glu Lys Ile Leu Ile Tyr Glu Leu Tyr Ser Glu 
        195                 200                 205             


Asp Leu Ser Asp Met His Tyr Arg Val Lys Glu Lys Ile Ile Lys Lys 
    210                 215                 220                 


Phe Glu Cys Asn Leu Leu Val Val Cys Ala Asn His Ile Ile Leu Cys 
225                 230                 235                 240 


Gln Glu Lys Arg Leu Gln Cys Leu Ser Phe Ser Gly Val Lys Glu Arg 
                245                 250                 255     


Glu Trp Gln Met Glu Ser Leu Ile Arg Tyr Ile Lys Val Ile Gly Gly 
            260                 265                 270         


Pro Pro Gly Arg Glu Gly Leu Leu Val Gly Leu Lys Asn Gly Gln Ile 
        275                 280                 285             


Leu Lys Ile Phe Val Asp Asn Leu Phe Ala Ile Val Leu Leu Lys Gln 
    290                 295                 300                 


Ala Thr Ala Val Arg Cys Leu Asp Met Ser Ala Ser Arg Lys Lys Leu 
305                 310                 315                 320 


Ala Val Val Asp Glu Asn Asp Thr Cys Leu Val Tyr Asp Ile Asp Thr 
                325                 330                 335     


Lys Glu Leu Leu Phe Gln Glu Pro Asn Ala Asn Ser Val Ala Trp Asn 
            340                 345                 350         


Thr Gln Cys Glu Asp Met Leu Cys Phe Ser Gly Gly Gly Tyr Leu Asn 
        355                 360                 365             


Ile Lys Ala Ser Thr Phe Pro Val His Arg Gln Lys Leu Gln Gly Phe 
    370                 375                 380                 


Val Val Gly Tyr Asn Gly Ser Lys Ile Phe Cys Leu His Val Phe Ser 
385                 390                 395                 400 


Ile Ser Ala Val Glu Val Pro Gln Ser Ala Pro Met Tyr Gln Tyr Leu 
                405                 410                 415     


Asp Arg Lys Leu Phe Lys Glu Ala Tyr Gln Ile Ala Cys Leu Gly Val 
            420                 425                 430         


Thr Asp Thr Asp Trp Arg Glu Leu Ala Met Glu Ala Leu Glu Gly Leu 
        435                 440                 445             


Asp Phe Glu Thr Ala Lys Lys Ala Phe Ile Arg Val Gln Asp Leu Arg 
    450                 455                 460                 


Tyr Leu Glu Leu Ile Ser Ser Ile Glu Glu Arg Lys Lys Arg Gly Glu 
465                 470                 475                 480 


Thr Asn Asn Asp Leu Phe Leu Ala Asp Val Phe Ser Tyr Gln Gly Lys 
                485                 490                 495     


Phe His Glu Ala Ala Lys Leu Tyr Lys Arg Ser Gly His Glu Asn Leu 
            500                 505                 510         


Ala Leu Glu Met Tyr Thr Asp Leu Cys Met Phe Glu Tyr Ala Lys Asp 
        515                 520                 525             


Phe Leu Gly Ser Gly Asp Pro Lys Glu Thr Lys Met Leu Ile Thr Lys 
    530                 535                 540                 


Gln Ala Asp Trp Ala Arg Asn Ile Lys Glu Pro Lys Ala Ala Val Glu 
545                 550                 555                 560 


Met Tyr Ile Ser Ala Gly Glu His Val Lys Ala Ile Glu Ile Cys Gly 
                565                 570                 575     


Asp His Gly Trp Val Asp Met Leu Ile Asp Ile Ala Arg Lys Leu Asp 
            580                 585                 590         


Lys Ala Glu Arg Glu Pro Leu Leu Leu Cys Ala Thr Tyr Leu Lys Lys 
        595                 600                 605             


Leu Asp Ser Pro Gly Tyr Ala Ala Glu Thr Tyr Leu Lys Met Gly Asp 
    610                 615                 620                 


Leu Lys Ser Leu Val Gln Leu His Val Glu Thr Gln Arg Trp Asp Glu 
625                 630                 635                 640 


Ala Phe Ala Leu Gly Glu Lys His Pro Glu Phe Lys Asp Asp Ile Tyr 
                645                 650                 655     


Met Pro Tyr Ala Gln Trp Leu Ala Glu Asn Asp Arg Phe Glu Glu Ala 
            660                 665                 670         


Gln Lys Ala Phe His Lys Ala Gly Arg Gln Arg Glu Ala Val Gln Val 
        675                 680                 685             


Leu Glu Gln Leu Thr Asn Asn Ala Val Ala Glu Ser Arg Phe Asn Asp 
    690                 695                 700                 


Ala Ala Tyr Tyr Tyr Trp Met Leu Ser Met Gln Cys Leu Asp Ile Ala 
705                 710                 715                 720 


Gln Asp Pro Ala Gln Lys Asp Thr Met Leu Gly Lys Phe Tyr His Phe 
                725                 730                 735     


Gln Arg Leu Ala Glu Leu Tyr His Gly Tyr His Ala Ile His Arg His 
            740                 745                 750         


Thr Glu Asp Pro Phe Ser Val His Arg Pro Glu Thr Leu Phe Asn Ile 
        755                 760                 765             


Ser Arg Phe Leu Leu His Ser Leu Pro Lys Asp Thr Pro Ser Gly Ile 
    770                 775                 780                 


Ser Lys Val Lys Ile Leu Phe Thr Leu Ala Lys Gln Ser Lys Ala Leu 
785                 790                 795                 800 


Gly Ala Tyr Arg Leu Ala Arg His Ala Tyr Asp Lys Leu Arg Gly Leu 
                805                 810                 815     


Tyr Ile Pro Ala Arg Phe Gln Lys Ser Ile Glu Leu Gly Thr Leu Thr 
            820                 825                 830         


Ile Arg Ala Lys Pro Phe His Asp Ser Glu Glu Leu Val Pro Leu Cys 
        835                 840                 845             


Tyr Arg Cys Ser Thr Asn Asn Pro Leu Leu Asn Asn Leu Gly Asn Val 
    850                 855                 860                 


Cys Ile Asn Cys Arg Gln Pro Phe Ile Phe Ser Ala Ser Ser Tyr Asp 
865                 870                 875                 880 


Val Leu His Leu Val Glu Phe Tyr Leu Glu Glu Gly Ile Thr Asp Glu 
                885                 890                 895     


Glu Ala Ile Ser Leu Ile Asp Leu Glu Val Leu Arg Pro Lys Arg Asp 
            900                 905                 910         


Asp Arg Gln Leu Glu Ile Ala Asn Asn Ser Ser Gln Ile Leu Arg Leu 
        915                 920                 925             


Val Glu Thr Lys Asp Ser Ile Gly Asp Glu Asp Pro Phe Thr Ala Lys 
    930                 935                 940                 


Leu Ser Phe Glu Gln Gly Gly Ser Glu Phe Val Pro Val Val Val Ser 
945                 950                 955                 960 


Arg Leu Val Leu Arg Ser Met Ser Arg Arg Asp Val Leu Ile Lys Arg 
                965                 970                 975     


Trp Pro Pro Pro Leu Arg Trp Gln Tyr Phe Arg Ser Leu Leu Pro Asp 
            980                 985                 990         


Ala Ser Ile Thr Met Cys Pro Ser  Cys Phe Gln Met Phe  His Ser Glu 
        995                 1000                 1005             


Asp Tyr  Glu Leu Leu Val Leu  Gln His Gly Cys Cys  Pro Tyr Cys 
    1010                 1015                 1020             


Arg Arg  Cys Lys Asp Asp Pro  Gly Pro 
    1025                 1030         


<210>  5347
<211>  1462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT140__Homo_sapiens__NP_055529

<400>  5347

Met Ala Leu Tyr Tyr Asp His Gln Ile Glu Ala Pro Asp Ala Ala Gly 
1               5                   10                  15      


Ser Pro Ser Phe Ile Ser Trp His Pro Val His Pro Phe Leu Ala Val 
            20                  25                  30          


Ala Tyr Ile Ser Thr Thr Ser Thr Gly Ser Val Asp Ile Tyr Leu Glu 
        35                  40                  45              


Gln Gly Glu Cys Val Pro Asp Thr His Val Glu Arg Pro Phe Arg Val 
    50                  55                  60                  


Ala Ser Leu Cys Trp His Pro Thr Arg Leu Val Leu Ala Val Gly Trp 
65                  70                  75                  80  


Glu Thr Gly Glu Val Thr Val Phe Asn Lys Gln Asp Lys Glu Gln His 
                85                  90                  95      


Thr Met Pro Leu Thr His Thr Ala Asp Ile Thr Val Leu Arg Trp Ser 
            100                 105                 110         


Pro Ser Gly Asn Cys Leu Leu Ser Gly Asp Arg Leu Gly Val Leu Leu 
        115                 120                 125             


Leu Trp Arg Leu Asp Gln Arg Gly Arg Val Gln Gly Thr Pro Leu Leu 
    130                 135                 140                 


Lys His Glu Tyr Gly Lys His Leu Thr His Cys Ile Phe Arg Leu Pro 
145                 150                 155                 160 


Pro Pro Gly Glu Asp Leu Val Gln Leu Ala Lys Ala Ala Val Ser Gly 
                165                 170                 175     


Asp Glu Lys Ala Leu Asp Met Phe Asn Trp Lys Lys Ser Ser Ser Gly 
            180                 185                 190         


Ser Leu Leu Lys Met Gly Ser His Glu Gly Leu Leu Phe Phe Val Ser 
        195                 200                 205             


Leu Met Asp Gly Thr Val His Tyr Val Asp Glu Lys Gly Lys Thr Thr 
    210                 215                 220                 


Gln Val Val Ser Ala Asp Ser Thr Ile Gln Met Leu Phe Tyr Met Glu 
225                 230                 235                 240 


Lys Arg Glu Ala Leu Val Val Val Thr Glu Asn Leu Arg Leu Ser Leu 
                245                 250                 255     


Tyr Thr Val Pro Pro Glu Gly Lys Ala Glu Glu Val Met Lys Val Lys 
            260                 265                 270         


Leu Ser Gly Lys Thr Gly Arg Arg Ala Asp Ile Ala Leu Ile Glu Gly 
        275                 280                 285             


Ser Leu Leu Val Met Ala Val Gly Glu Ala Ala Leu Arg Phe Trp Asp 
    290                 295                 300                 


Ile Glu Arg Gly Glu Asn Tyr Ile Leu Ser Pro Asp Glu Lys Phe Gly 
305                 310                 315                 320 


Phe Glu Lys Gly Glu Asn Met Asn Cys Val Cys Tyr Cys Lys Val Lys 
                325                 330                 335     


Gly Leu Leu Ala Ala Gly Thr Asp Arg Gly Arg Val Ala Met Trp Arg 
            340                 345                 350         


Lys Val Pro Asp Phe Leu Gly Ser Pro Gly Ala Glu Gly Lys Asp Arg 
        355                 360                 365             


Trp Ala Leu Gln Thr Pro Thr Glu Leu Gln Gly Asn Ile Thr Gln Ile 
    370                 375                 380                 


Gln Trp Gly Ser Arg Lys Asn Leu Leu Ala Val Asn Ser Val Ile Ser 
385                 390                 395                 400 


Val Ala Ile Leu Ser Glu Arg Ala Met Ser Ser His Phe His Gln Gln 
                405                 410                 415     


Val Ala Ala Met Gln Val Ser Pro Ser Leu Leu Asn Val Cys Phe Leu 
            420                 425                 430         


Ser Thr Gly Val Ala His Ser Leu Arg Thr Asp Met His Ile Ser Gly 
        435                 440                 445             


Val Phe Ala Thr Lys Asp Ala Val Ala Val Trp Asn Gly Arg Gln Val 
    450                 455                 460                 


Ala Ile Phe Glu Leu Ser Gly Ala Ala Ile Arg Ser Ala Gly Thr Phe 
465                 470                 475                 480 


Leu Cys Glu Thr Pro Val Leu Ala Met His Glu Glu Asn Val Tyr Thr 
                485                 490                 495     


Val Glu Ser Asn Arg Val Gln Val Arg Thr Trp Gln Gly Thr Val Lys 
            500                 505                 510         


Gln Leu Leu Leu Phe Ser Glu Thr Glu Gly Asn Pro Cys Phe Leu Asp 
        515                 520                 525             


Ile Cys Gly Asn Phe Leu Val Val Gly Thr Asp Leu Ala His Phe Lys 
    530                 535                 540                 


Ser Phe Asp Leu Ser Arg Arg Glu Ala Lys Ala His Cys Ser Cys Arg 
545                 550                 555                 560 


Ser Leu Ala Glu Leu Val Pro Gly Val Gly Gly Ile Ala Ser Leu Arg 
                565                 570                 575     


Cys Ser Ser Ser Gly Ser Thr Ile Ser Ile Leu Pro Ser Lys Ala Asp 
            580                 585                 590         


Asn Ser Pro Asp Ser Lys Ile Cys Phe Tyr Asp Val Glu Met Asp Thr 
        595                 600                 605             


Val Thr Val Phe Asp Phe Lys Thr Gly Gln Ile Asp Arg Arg Glu Thr 
    610                 615                 620                 


Leu Ser Phe Asn Glu Gln Glu Thr Asn Lys Ser His Leu Phe Val Asp 
625                 630                 635                 640 


Glu Gly Leu Lys Asn Tyr Val Pro Val Asn His Phe Trp Asp Gln Ser 
                645                 650                 655     


Glu Pro Arg Leu Phe Val Cys Glu Ala Val Gln Glu Thr Pro Arg Ser 
            660                 665                 670         


Gln Pro Gln Ser Ala Asn Gly Gln Pro Gln Asp Gly Arg Ala Gly Pro 
        675                 680                 685             


Ala Ala Asp Val Leu Ile Leu Ser Phe Phe Ile Ser Glu Glu His Gly 
    690                 695                 700                 


Phe Leu Leu His Glu Ser Phe Pro Arg Pro Ala Thr Ser His Ser Leu 
705                 710                 715                 720 


Leu Gly Met Glu Val Pro Tyr Tyr Tyr Phe Thr Arg Lys Pro Glu Glu 
                725                 730                 735     


Ala Asp Arg Glu Asp Glu Val Glu Pro Gly Cys His His Ile Pro Gln 
            740                 745                 750         


Met Val Ser Arg Arg Pro Leu Arg Asp Phe Val Gly Leu Glu Asp Cys 
        755                 760                 765             


Asp Lys Ala Thr Arg Asp Ala Met Leu His Phe Ser Phe Phe Val Thr 
    770                 775                 780                 


Ile Gly Asp Met Asp Glu Ala Phe Lys Ser Ile Lys Leu Ile Lys Ser 
785                 790                 795                 800 


Glu Ala Val Trp Glu Asn Met Ala Arg Met Cys Val Lys Thr Gln Arg 
                805                 810                 815     


Leu Asp Val Ala Lys Val Cys Leu Gly Asn Met Gly His Ala Arg Gly 
            820                 825                 830         


Ala Arg Ala Leu Arg Glu Ala Glu Gln Glu Pro Glu Leu Glu Ala Arg 
        835                 840                 845             


Val Ala Val Leu Ala Thr Gln Leu Gly Met Leu Glu Asp Ala Glu Gln 
    850                 855                 860                 


Leu Tyr Arg Lys Cys Lys Arg His Asp Leu Leu Asn Lys Phe Tyr Gln 
865                 870                 875                 880 


Ala Ala Gly Arg Trp Gln Glu Ala Leu Gln Val Ala Glu His His Asp 
                885                 890                 895     


Arg Val His Leu Arg Ser Thr Tyr His Arg Tyr Ala Gly His Leu Glu 
            900                 905                 910         


Ala Ser Ala Asp Cys Ser Arg Ala Leu Ser Tyr Tyr Glu Lys Ser Asp 
        915                 920                 925             


Thr His Arg Phe Glu Val Pro Arg Met Leu Ser Glu Asp Leu Pro Ser 
    930                 935                 940                 


Leu Glu Leu Tyr Val Asn Lys Met Lys Asp Lys Thr Leu Trp Arg Trp 
945                 950                 955                 960 


Trp Ala Gln Tyr Leu Glu Ser Gln Gly Glu Met Asp Ala Ala Leu His 
                965                 970                 975     


Tyr Tyr Glu Leu Ala Arg Asp His Phe Ser Leu Val Arg Ile His Cys 
            980                 985                 990         


Phe Gln Gly Asn Val Gln Lys Ala  Ala Gln Ile Ala Asn  Glu Thr Gly 
        995                 1000                 1005             


Asn Leu  Ala Ala Ser Tyr His  Leu Ala Arg Gln Tyr  Glu Ser Gln 
    1010                 1015                 1020             


Glu Glu  Val Gly Gln Ala Val  His Phe Tyr Thr Arg  Ala Gln Ala 
    1025                 1030                 1035             


Phe Lys  Asn Ala Ile Arg Leu  Cys Lys Glu Asn Gly  Leu Asp Asp 
    1040                 1045                 1050             


Gln Leu  Met Asn Leu Ala Leu  Leu Ser Ser Pro Glu  Asp Met Ile 
    1055                 1060                 1065             


Glu Ala  Ala Arg Tyr Tyr Glu  Glu Lys Gly Val Gln  Met Asp Arg 
    1070                 1075                 1080             


Ala Val  Met Leu Tyr His Lys  Ala Gly His Phe Ser  Lys Ala Leu 
    1085                 1090                 1095             


Glu Leu  Ala Phe Ala Thr Gln  Gln Phe Val Ala Leu  Gln Leu Ile 
    1100                 1105                 1110             


Ala Glu  Asp Leu Asp Glu Thr  Ser Asp Pro Ala Leu  Leu Ala Arg 
    1115                 1120                 1125             


Cys Ser  Asp Phe Phe Ile Glu  His Ser Gln Tyr Glu  Arg Ala Val 
    1130                 1135                 1140             


Glu Leu  Leu Leu Ala Ala Arg  Lys Tyr Gln Glu Ala  Leu Gln Leu 
    1145                 1150                 1155             


Cys Leu  Gly Gln Asn Met Ser  Ile Thr Glu Glu Met  Ala Glu Lys 
    1160                 1165                 1170             


Met Thr  Val Ala Lys Asp Ser  Ser Asp Leu Pro Glu  Glu Ser Arg 
    1175                 1180                 1185             


Arg Glu  Leu Leu Glu Gln Ile  Ala Asp Cys Cys Met  Arg Gln Gly 
    1190                 1195                 1200             


Ser Tyr  His Leu Ala Thr Lys  Lys Tyr Thr Gln Ala  Gly Asn Lys 
    1205                 1210                 1215             


Leu Lys  Ala Met Arg Ala Leu  Leu Lys Ser Gly Asp  Thr Glu Lys 
    1220                 1225                 1230             


Ile Thr  Phe Phe Ala Ser Val  Ser Arg Gln Lys Glu  Ile Tyr Ile 
    1235                 1240                 1245             


Met Ala  Ala Asn Tyr Leu Gln  Ser Leu Asp Trp Arg  Lys Glu Pro 
    1250                 1255                 1260             


Glu Ile  Met Lys Asn Ile Ile  Gly Phe Tyr Thr Lys  Gly Arg Ala 
    1265                 1270                 1275             


Leu Asp  Leu Leu Ala Gly Phe  Tyr Asp Ala Cys Ala  Gln Val Glu 
    1280                 1285                 1290             


Ile Asp  Glu Tyr Gln Asn Tyr  Asp Lys Ala His Gly  Ala Leu Thr 
    1295                 1300                 1305             


Glu Ala  Tyr Lys Cys Leu Ala  Lys Ala Lys Ala Lys  Ser Pro Leu 
    1310                 1315                 1320             


Asp Gln  Glu Thr Arg Leu Ala  Gln Leu Gln Ser Arg  Met Ala Leu 
    1325                 1330                 1335             


Val Lys  Arg Phe Ile Gln Ala  Arg Arg Thr Tyr Thr  Glu Asp Pro 
    1340                 1345                 1350             


Lys Glu  Ser Ile Lys Gln Cys  Glu Leu Leu Leu Glu  Glu Pro Asp 
    1355                 1360                 1365             


Leu Asp  Ser Thr Ile Arg Ile  Gly Asp Val Tyr Gly  Phe Leu Val 
    1370                 1375                 1380             


Glu His  Tyr Val Arg Lys Glu  Glu Tyr Gln Thr Ala  Tyr Arg Phe 
    1385                 1390                 1395             


Leu Glu  Glu Met Arg Arg Arg  Leu Pro Leu Ala Asn  Met Ser Tyr 
    1400                 1405                 1410             


Tyr Val  Ser Pro Gln Ala Val  Asp Ala Val His Arg  Gly Leu Gly 
    1415                 1420                 1425             


Leu Pro  Leu Pro Arg Thr Val  Pro Glu Gln Val Arg  His Asn Ser 
    1430                 1435                 1440             


Met Glu  Asp Ala Arg Glu Leu  Asp Glu Glu Val Val  Glu Glu Ala 
    1445                 1450                 1455             


Asp Asp  Asp Pro 
    1460         


<210>  5348
<211>  1749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT172__Homo_sapiens__NP_056477

<400>  5348

Met His Leu Lys His Leu Arg Thr Leu Leu Ser Pro Gln Asp Gly Ala 
1               5                   10                  15      


Ala Lys Val Thr Cys Met Ala Trp Ser Gln Asn Asn Ala Lys Phe Ala 
            20                  25                  30          


Val Cys Thr Val Asp Arg Val Val Leu Leu Tyr Asp Glu His Gly Glu 
        35                  40                  45              


Arg Arg Asp Lys Phe Ser Thr Lys Pro Ala Asp Met Lys Tyr Gly Arg 
    50                  55                  60                  


Lys Ser Tyr Met Val Lys Gly Met Ala Phe Ser Pro Asp Ser Thr Lys 
65                  70                  75                  80  


Ile Ala Ile Gly Gln Thr Asp Asn Ile Ile Tyr Val Tyr Lys Ile Gly 
                85                  90                  95      


Glu Asp Trp Gly Asp Lys Lys Val Ile Cys Asn Lys Phe Ile Gln Thr 
            100                 105                 110         


Ser Ala Val Thr Cys Leu Gln Trp Pro Ala Glu Tyr Ile Ile Val Phe 
        115                 120                 125             


Gly Leu Ala Glu Gly Lys Val Arg Leu Ala Asn Thr Lys Thr Asn Lys 
    130                 135                 140                 


Ser Ser Thr Ile Tyr Gly Thr Glu Ser Tyr Val Val Ser Leu Thr Thr 
145                 150                 155                 160 


Asn Cys Ser Gly Lys Gly Ile Leu Ser Gly His Ala Asp Gly Thr Ile 
                165                 170                 175     


Val Arg Tyr Phe Phe Asp Asp Glu Gly Ser Gly Glu Ser Gln Gly Lys 
            180                 185                 190         


Leu Val Asn His Pro Cys Pro Pro Tyr Ala Leu Ala Trp Ala Thr Asn 
        195                 200                 205             


Ser Ile Val Ala Ala Gly Cys Asp Arg Lys Ile Val Ala Tyr Gly Lys 
    210                 215                 220                 


Glu Gly His Met Leu Gln Thr Phe Asp Tyr Ser Arg Asp Pro Gln Glu 
225                 230                 235                 240 


Arg Glu Phe Thr Thr Ala Val Ser Ser Pro Gly Gly Gln Ser Val Val 
                245                 250                 255     


Leu Gly Ser Tyr Asp Arg Leu Arg Val Phe Asn Trp Ile Pro Arg Arg 
            260                 265                 270         


Ser Ile Trp Glu Glu Ala Lys Pro Lys Glu Ile Thr Asn Leu Tyr Thr 
        275                 280                 285             


Ile Thr Ala Leu Ala Trp Lys Arg Asp Gly Ser Arg Leu Cys Val Gly 
    290                 295                 300                 


Thr Leu Cys Gly Gly Val Glu Gln Phe Asp Cys Cys Leu Arg Arg Ser 
305                 310                 315                 320 


Ile Tyr Lys Asn Lys Phe Glu Leu Thr Tyr Val Gly Pro Ser Gln Val 
                325                 330                 335     


Ile Val Lys Asn Leu Ser Ser Gly Thr Arg Val Val Leu Lys Ser His 
            340                 345                 350         


Tyr Gly Tyr Glu Val Glu Glu Val Lys Ile Leu Gly Lys Glu Arg Tyr 
        355                 360                 365             


Leu Val Ala His Thr Ser Glu Thr Leu Leu Leu Gly Asp Leu Asn Thr 
    370                 375                 380                 


Asn Arg Leu Ser Glu Ile Ala Trp Gln Gly Ser Gly Gly Asn Glu Lys 
385                 390                 395                 400 


Tyr Phe Phe Glu Asn Glu Asn Val Cys Met Ile Phe Asn Ala Gly Glu 
                405                 410                 415     


Leu Thr Leu Val Glu Tyr Gly Asn Asn Asp Thr Leu Gly Ser Val Arg 
            420                 425                 430         


Thr Glu Phe Met Asn Pro His Leu Ile Ser Val Arg Ile Asn Glu Arg 
        435                 440                 445             


Cys Gln Arg Gly Thr Glu Asp Asn Lys Lys Leu Ala Tyr Leu Ile Asp 
    450                 455                 460                 


Ile Lys Thr Ile Ala Ile Val Asp Leu Ile Gly Gly Tyr Asn Ile Gly 
465                 470                 475                 480 


Thr Val Ser His Glu Ser Arg Val Asp Trp Leu Glu Leu Asn Glu Thr 
                485                 490                 495     


Gly His Lys Leu Leu Phe Arg Asp Arg Lys Leu Arg Leu His Leu Tyr 
            500                 505                 510         


Asp Ile Glu Ser Cys Ser Lys Thr Met Ile Leu Asn Phe Cys Ser Tyr 
        515                 520                 525             


Met Gln Trp Val Pro Gly Ser Asp Val Leu Val Ala Gln Asn Arg Asn 
    530                 535                 540                 


Ser Leu Cys Val Trp Tyr Asn Ile Glu Ala Pro Glu Arg Val Thr Met 
545                 550                 555                 560 


Phe Thr Ile Arg Gly Asp Val Ile Gly Leu Glu Arg Gly Gly Gly Lys 
                565                 570                 575     


Thr Glu Val Met Val Met Glu Gly Val Thr Thr Val Ala Tyr Thr Leu 
            580                 585                 590         


Asp Glu Gly Leu Ile Glu Phe Gly Thr Ala Ile Asp Asp Gly Asn Tyr 
        595                 600                 605             


Ile Arg Ala Thr Ala Phe Leu Glu Thr Leu Glu Met Thr Pro Glu Thr 
    610                 615                 620                 


Glu Ala Met Trp Lys Thr Leu Ser Lys Leu Ala Leu Glu Ala Arg Gln 
625                 630                 635                 640 


Leu His Ile Ala Glu Arg Cys Phe Ser Ala Leu Gly Gln Val Ala Lys 
                645                 650                 655     


Ala Arg Phe Leu His Glu Thr Asn Glu Ile Ala Asp Gln Val Ser Arg 
            660                 665                 670         


Glu Tyr Gly Gly Glu Gly Thr Asp Phe Tyr Gln Val Arg Ala Arg Leu 
        675                 680                 685             


Ala Met Leu Glu Lys Asn Tyr Lys Leu Ala Glu Met Ile Phe Leu Glu 
    690                 695                 700                 


Gln Asn Ala Val Glu Glu Ala Met Gly Met Tyr Gln Glu Leu His Arg 
705                 710                 715                 720 


Trp Asp Glu Cys Ile Ala Val Ala Glu Ala Lys Gly His Pro Ala Leu 
                725                 730                 735     


Glu Lys Leu Arg Arg Ser Tyr Tyr Gln Trp Leu Met Asp Thr Gln Gln 
            740                 745                 750         


Glu Glu Arg Ala Gly Glu Leu Gln Glu Ser Gln Gly Asp Gly Leu Ala 
        755                 760                 765             


Ala Ile Ser Leu Tyr Leu Lys Ala Gly Leu Pro Ala Lys Ala Ala Arg 
    770                 775                 780                 


Leu Val Leu Thr Arg Glu Glu Leu Leu Ala Asn Thr Glu Leu Val Glu 
785                 790                 795                 800 


His Ile Thr Ala Ala Leu Ile Lys Gly Glu Leu Tyr Glu Arg Ala Gly 
                805                 810                 815     


Asp Leu Phe Glu Lys Ile His Asn Pro Gln Lys Ala Leu Glu Cys Tyr 
            820                 825                 830         


Arg Lys Gly Asn Ala Phe Met Lys Ala Val Glu Leu Ala Arg Leu Ala 
        835                 840                 845             


Phe Pro Val Glu Val Val Lys Leu Glu Glu Ala Trp Gly Asp His Leu 
    850                 855                 860                 


Val Gln Gln Lys Gln Leu Asp Ala Ala Ile Asn His Tyr Ile Glu Ala 
865                 870                 875                 880 


Arg Cys Ser Ile Lys Ala Ile Glu Ala Ala Leu Gly Ala Arg Gln Trp 
                885                 890                 895     


Lys Lys Ala Ile Tyr Ile Leu Asp Leu Gln Asp Arg Asn Thr Ala Ser 
            900                 905                 910         


Lys Tyr Tyr Pro Leu Val Ala Gln His Tyr Ala Ser Leu Gln Glu Tyr 
        915                 920                 925             


Glu Ile Ala Glu Glu Leu Tyr Thr Lys Gly Asp Arg Thr Lys Asp Ala 
    930                 935                 940                 


Ile Asp Met Tyr Thr Gln Ala Gly Arg Trp Glu Gln Ala His Lys Leu 
945                 950                 955                 960 


Ala Met Lys Cys Met Arg Pro Glu Asp Val Ser Val Leu Tyr Ile Thr 
                965                 970                 975     


Gln Ala Gln Glu Met Glu Lys Gln Gly Lys Tyr Arg Glu Ala Glu Arg 
            980                 985                 990         


Leu Tyr Val Thr Val Gln Glu Pro  Asp Leu Ala Ile Thr  Met Tyr Lys 
        995                 1000                 1005             


Lys His  Lys Leu Tyr Asp Asp  Met Ile Arg Leu Val  Gly Lys His 
    1010                 1015                 1020             


His Pro  Asp Leu Leu Ser Asp  Thr His Leu His Leu  Gly Lys Glu 
    1025                 1030                 1035             


Leu Glu  Ala Glu Gly Arg Leu  Gln Glu Ala Glu Tyr  His Tyr Leu 
    1040                 1045                 1050             


Glu Ala  Gln Glu Trp Lys Ala  Thr Val Asn Met Tyr  Arg Ala Ser 
    1055                 1060                 1065             


Gly Leu  Trp Glu Glu Ala Tyr  Arg Val Ala Arg Thr  Gln Gly Gly 
    1070                 1075                 1080             


Ala Asn  Ala His Lys His Val  Ala Tyr Leu Trp Ala  Lys Ser Leu 
    1085                 1090                 1095             


Gly Gly  Glu Ala Ala Val Arg  Leu Leu Asn Lys Leu  Gly Leu Leu 
    1100                 1105                 1110             


Glu Ala  Ala Val Asp His Ala  Ala Asp Asn Cys Ser  Phe Glu Phe 
    1115                 1120                 1125             


Ala Phe  Glu Leu Ser Arg Leu  Ala Leu Lys His Lys  Thr Pro Glu 
    1130                 1135                 1140             


Val His  Leu Lys Tyr Ala Met  Phe Leu Glu Asp Glu  Gly Lys Phe 
    1145                 1150                 1155             


Glu Glu  Ala Glu Ala Glu Phe  Ile Arg Ala Gly Lys  Pro Lys Glu 
    1160                 1165                 1170             


Ala Val  Leu Met Phe Val His  Asn Gln Asp Trp Glu  Ala Ala Gln 
    1175                 1180                 1185             


Arg Val  Ala Glu Ala His Asp  Pro Asp Ser Val Ala  Glu Val Leu 
    1190                 1195                 1200             


Val Gly  Gln Ala Arg Gly Ala  Leu Glu Glu Lys Asp  Phe Gln Lys 
    1205                 1210                 1215             


Ala Glu  Gly Leu Leu Leu Arg  Ala Gln Arg Pro Gly  Leu Ala Leu 
    1220                 1225                 1230             


Asn Tyr  Tyr Lys Glu Ala Gly  Leu Trp Ser Asp Ala  Leu Arg Ile 
    1235                 1240                 1245             


Cys Lys  Asp Tyr Val Pro Ser  Gln Leu Glu Ala Leu  Gln Glu Glu 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ala Thr Lys  Lys Gly Ala Arg Gly  Val Glu Gly 
    1265                 1270                 1275             


Phe Val  Glu Gln Ala Arg His  Trp Glu Gln Ala Gly  Glu Tyr Ser 
    1280                 1285                 1290             


Arg Ala  Val Asp Cys Tyr Leu  Lys Val Arg Asp Ser  Gly Asn Ser 
    1295                 1300                 1305             


Gly Leu  Ala Glu Lys Cys Trp  Met Lys Ala Ala Glu  Leu Ser Ile 
    1310                 1315                 1320             


Lys Phe  Leu Pro Pro Gln Arg  Asn Met Glu Val Val  Leu Ala Val 
    1325                 1330                 1335             


Gly Pro  Gln Leu Ile Gly Ile  Gly Lys His Ser Ala  Ala Ala Glu 
    1340                 1345                 1350             


Leu Tyr  Leu Asn Leu Asp Leu  Val Lys Glu Ala Ile  Asp Ala Phe 
    1355                 1360                 1365             


Ile Glu  Gly Glu Glu Trp Asn  Lys Ala Lys Arg Val  Ala Lys Glu 
    1370                 1375                 1380             


Leu Asp  Pro Arg Tyr Glu Asp  Tyr Val Asp Gln His  Tyr Lys Glu 
    1385                 1390                 1395             


Phe Leu  Lys Asn Gln Gly Lys  Val Asp Ser Leu Val  Gly Val Asp 
    1400                 1405                 1410             


Val Ile  Ala Ala Leu Asp Leu  Tyr Val Glu Gln Gly  Gln Trp Asp 
    1415                 1420                 1425             


Lys Cys  Ile Glu Thr Ala Thr  Lys Gln Asn Tyr Lys  Ile Leu His 
    1430                 1435                 1440             


Lys Tyr  Val Ala Leu Tyr Ala  Thr His Leu Ile Arg  Glu Gly Ser 
    1445                 1450                 1455             


Ser Ala  Gln Ala Leu Ala Leu  Tyr Val Gln His Gly  Ala Pro Ala 
    1460                 1465                 1470             


Asn Pro  Gln Asn Phe Asn Ile  Tyr Lys Arg Ile Phe  Thr Asp Met 
    1475                 1480                 1485             


Val Ser  Ser Pro Gly Thr Asn  Cys Ala Glu Ala Tyr  His Ser Trp 
    1490                 1495                 1500             


Ala Asp  Leu Arg Asp Val Leu  Phe Asn Leu Cys Glu  Asn Leu Val 
    1505                 1510                 1515             


Lys Ser  Ser Glu Ala Asn Ser  Pro Ala His Glu Glu  Phe Lys Thr 
    1520                 1525                 1530             


Met Leu  Leu Ile Ala His Tyr  Tyr Ala Thr Arg Ser  Ala Ala Gln 
    1535                 1540                 1545             


Ser Val  Lys Gln Leu Glu Thr  Val Ala Ala Arg Leu  Ser Val Ser 
    1550                 1555                 1560             


Leu Leu  Arg His Thr Gln Leu  Leu Pro Val Asp Lys  Ala Phe Tyr 
    1565                 1570                 1575             


Glu Ala  Gly Ile Ala Ala Lys  Ala Val Gly Trp Asp  Asn Met Ala 
    1580                 1585                 1590             


Phe Ile  Phe Leu Asn Arg Phe  Leu Asp Leu Thr Asp  Ala Ile Glu 
    1595                 1600                 1605             


Glu Gly  Thr Leu Asp Gly Leu  Asp His Ser Asp Phe  Gln Asp Thr 
    1610                 1615                 1620             


Asp Ile  Pro Phe Glu Val Pro  Leu Pro Ala Lys Gln  His Val Pro 
    1625                 1630                 1635             


Glu Ala  Glu Arg Glu Glu Val  Arg Asp Trp Val Leu  Thr Val Ser 
    1640                 1645                 1650             


Met Asp  Gln Arg Leu Glu Gln  Val Leu Pro Arg Asp  Glu Arg Gly 
    1655                 1660                 1665             


Ala Tyr  Glu Ala Ser Leu Val  Ala Ala Ser Thr Gly  Val Arg Ala 
    1670                 1675                 1680             


Leu Pro  Cys Leu Ile Thr Gly  Tyr Pro Ile Leu Arg  Asn Lys Ile 
    1685                 1690                 1695             


Glu Phe  Lys Arg Pro Gly Lys  Ala Ala Asn Lys Asp  Asn Trp Asn 
    1700                 1705                 1710             


Lys Phe  Leu Met Ala Ile Lys  Thr Ser His Ser Pro  Val Cys Gln 
    1715                 1720                 1725             


Asp Val  Leu Lys Phe Ile Ser  Gln Trp Cys Gly Gly  Leu Pro Ser 
    1730                 1735                 1740             


Thr Ser  Phe Ser Phe Gln 
    1745                 


<210>  5349
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT27__Homo_sapiens__NP_001171172

<400>  5349

Met Val Lys Leu Ala Ala Lys Cys Ile Leu Ala Gly Asp Pro Ala Val 
1               5                   10                  15      


Gly Lys Thr Ala Leu Ala Gln Ile Phe Arg Ser Asp Gly Ala His Phe 
            20                  25                  30          


Gln Lys Ser Tyr Thr Leu Thr Thr Gly Met Asp Leu Val Val Lys Thr 
        35                  40                  45              


Val Pro Val Pro Asp Thr Gly Asp Ser Val Glu Leu Phe Ile Phe Asp 
    50                  55                  60                  


Ser Ala Gly Lys Glu Leu Phe Ser Glu Met Leu Asp Lys Leu Trp Glu 
65                  70                  75                  80  


Ser Pro Asn Val Leu Cys Leu Val Tyr Asp Val Thr Asn Glu Glu Ser 
                85                  90                  95      


Phe Asn Asn Cys Ser Lys Trp Leu Glu Lys Ala Arg Ser Gln Ala Pro 
            100                 105                 110         


Gly Ile Ser Leu Pro Gly Val Leu Val Gly Asn Lys Thr Asp Leu Ala 
        115                 120                 125             


Gly Arg Arg Ala Val Asp Ser Ala Glu Ala Arg Ala Trp Ala Leu Gly 
    130                 135                 140                 


Gln Gly Leu Glu Cys Phe Glu Thr Ser Val Lys Glu Met Glu Asn Phe 
145                 150                 155                 160 


Glu Ala Pro Phe His Cys Leu Ala Lys Gln Phe His Gln Leu Tyr Arg 
                165                 170                 175     


Glu Lys Val Glu Val Phe Arg Ala Leu Ala 
            180                 185     


<210>  5350
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT43__Homo_sapiens__NP_001096034

<400>  5350

Met Glu Asp Leu Leu Asp Leu Asp Glu Glu Leu Arg Tyr Ser Leu Ala 
1               5                   10                  15      


Thr Ser Arg Ala Lys Met Gly Arg Arg Ala Gln Gln Glu Ser Ala Gln 
            20                  25                  30          


Ala Glu Asn His Leu Asn Gly Lys Asn Ser Ser Leu Thr Leu Thr Gly 
        35                  40                  45              


Glu Thr Ser Ser Ala Lys Leu Pro Arg Cys Arg Gln Gly Gly Trp Ala 
    50                  55                  60                  


Gly Asp Ser Val Lys Ala Ser Lys Phe Arg Arg Lys Ala Ser Glu Glu 
65                  70                  75                  80  


Ile Glu Asp Phe Arg Leu Arg Pro Gln Ser Leu Asn Gly Ser Asp Tyr 
                85                  90                  95      


Gly Gly Asp Ile Pro Ile Ile Pro Asp Leu Glu Glu Val Gln Glu Glu 
            100                 105                 110         


Asp Phe Val Leu Gln Val Ala Ala Pro Pro Ser Ile Gln Ile Lys Arg 
        115                 120                 125             


Val Met Thr Tyr Arg Asp Leu Asp Asn Asp Leu Met Lys Tyr Ser Ala 
    130                 135                 140                 


Ile Gln Thr Leu Asp Gly Glu Ile Asp Leu Lys Leu Leu Thr Lys Val 
145                 150                 155                 160 


Leu Ala Pro Glu His Glu Val Arg Glu Asp Asp Val Gly Trp Asp Trp 
                165                 170                 175     


Asp His Leu Phe Thr Glu Val Ser Ser Glu Val Leu Thr Glu Trp Asp 
            180                 185                 190         


Pro Leu Gln Thr Glu Lys Glu Asp Pro Ala Gly Gln Ala Arg His Thr 
        195                 200                 205             


<210>  5351
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT57__Homo_sapiens__NP_060480

<400>  5351

Met Thr Ala Ala Leu Ala Val Val Thr Thr Ser Gly Leu Glu Asp Gly 
1               5                   10                  15      


Val Pro Arg Ser Arg Gly Glu Gly Thr Gly Glu Val Val Leu Glu Arg 
            20                  25                  30          


Gly Pro Gly Ala Ala Tyr His Met Phe Val Val Met Glu Asp Leu Val 
        35                  40                  45              


Glu Lys Leu Lys Leu Leu Arg Tyr Glu Glu Glu Phe Leu Arg Lys Ser 
    50                  55                  60                  


Asn Leu Lys Ala Pro Ser Arg His Tyr Phe Ala Leu Pro Thr Asn Pro 
65                  70                  75                  80  


Gly Glu Gln Phe Tyr Met Phe Cys Thr Leu Ala Ala Trp Leu Ile Asn 
                85                  90                  95      


Lys Ala Gly Arg Pro Phe Glu Gln Pro Gln Glu Tyr Asp Asp Pro Asn 
            100                 105                 110         


Ala Thr Ile Ser Asn Ile Leu Ser Glu Leu Arg Ser Phe Gly Arg Thr 
        115                 120                 125             


Ala Asp Phe Pro Pro Ser Lys Leu Lys Ser Gly Tyr Gly Glu His Val 
    130                 135                 140                 


Cys Tyr Val Leu Asp Cys Phe Ala Glu Glu Ala Leu Lys Tyr Ile Gly 
145                 150                 155                 160 


Phe Thr Trp Lys Arg Pro Ile Tyr Pro Val Glu Glu Leu Glu Glu Glu 
                165                 170                 175     


Ser Val Ala Glu Asp Asp Ala Glu Leu Thr Leu Asn Lys Val Asp Glu 
            180                 185                 190         


Glu Phe Val Glu Glu Glu Thr Asp Asn Glu Glu Asn Phe Ile Asp Leu 
        195                 200                 205             


Asn Val Leu Lys Ala Gln Thr Tyr His Leu Asp Met Asn Glu Thr Ala 
    210                 215                 220                 


Lys Gln Glu Asp Ile Leu Glu Ser Thr Thr Asp Ala Ala Glu Trp Ser 
225                 230                 235                 240 


Leu Glu Val Glu Arg Val Leu Pro Gln Leu Lys Val Thr Ile Arg Thr 
                245                 250                 255     


Asp Asn Lys Asp Trp Arg Ile His Val Asp Gln Met His Gln His Arg 
            260                 265                 270         


Ser Gly Ile Glu Ser Ala Leu Lys Glu Thr Lys Gly Phe Leu Asp Lys 
        275                 280                 285             


Leu His Asn Glu Ile Thr Arg Thr Leu Glu Lys Ile Ser Ser Arg Glu 
    290                 295                 300                 


Lys Tyr Ile Asn Asn Gln Leu Glu Asn Leu Val Gln Glu Tyr Arg Ala 
305                 310                 315                 320 


Ala Gln Ala Gln Leu Ser Glu Ala Lys Glu Arg Tyr Gln Gln Gly Asn 
                325                 330                 335     


Gly Gly Val Thr Glu Arg Thr Arg Leu Leu Ser Glu Val Met Glu Glu 
            340                 345                 350         


Leu Glu Lys Val Lys Gln Glu Met Glu Glu Lys Gly Ser Ser Met Thr 
        355                 360                 365             


Asp Gly Ala Pro Leu Val Lys Ile Lys Gln Ser Leu Thr Lys Leu Lys 
    370                 375                 380                 


Gln Glu Thr Val Glu Met Asp Ile Arg Ile Gly Ile Val Glu His Thr 
385                 390                 395                 400 


Leu Leu Gln Ser Lys Leu Lys Glu Lys Ser Asn Met Thr Arg Asn Met 
                405                 410                 415     


His Ala Thr Val Ile Pro Glu Pro Ala Thr Gly Phe Tyr 
            420                 425                 


<210>  5352
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT74__Homo_sapiens__NP_001092693

<400>  5352

Met Ala Ser Asn His Lys Ser Ser Ala Ala Arg Pro Val Ser Arg Gly 
1               5                   10                  15      


Gly Val Gly Leu Thr Gly Arg Pro Pro Ser Gly Ile Arg Pro Leu Ser 
            20                  25                  30          


Gly Asn Ile Arg Val Ala Thr Ala Met Pro Pro Gly Thr Ala Arg Pro 
        35                  40                  45              


Gly Ser Arg Gly Cys Pro Ile Gly Thr Gly Gly Val Leu Ser Ser Gln 
    50                  55                  60                  


Ile Lys Val Ala His Arg Pro Val Thr Gln Gln Gly Leu Thr Gly Met 
65                  70                  75                  80  


Lys Thr Gly Thr Lys Gly Pro Gln Arg Gln Ile Leu Asp Lys Ser Tyr 
                85                  90                  95      


Tyr Leu Gly Leu Leu Arg Ser Lys Ile Ser Glu Leu Thr Thr Glu Val 
            100                 105                 110         


Asn Lys Leu Gln Lys Gly Ile Glu Met Tyr Asn Gln Glu Asn Ser Val 
        115                 120                 125             


Tyr Leu Ser Tyr Glu Lys Arg Ala Glu Thr Leu Ala Val Glu Ile Lys 
    130                 135                 140                 


Glu Leu Gln Gly Gln Leu Ala Asp Tyr Asn Met Leu Val Asp Lys Leu 
145                 150                 155                 160 


Asn Thr Asn Thr Glu Met Glu Glu Val Met Asn Asp Tyr Asn Met Leu 
                165                 170                 175     


Lys Ala Gln Asn Asp Arg Glu Thr Gln Ser Leu Asp Val Ile Phe Thr 
            180                 185                 190         


Glu Arg Gln Ala Lys Glu Lys Gln Ile Arg Ser Val Glu Glu Glu Ile 
        195                 200                 205             


Glu Gln Glu Lys Gln Ala Thr Asp Asp Ile Ile Lys Asn Met Ser Phe 
    210                 215                 220                 


Glu Asn Gln Val Lys Tyr Leu Glu Met Lys Thr Thr Asn Glu Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Leu Asp Thr Leu Gln Gln Gln Leu Asp Ser Gln Asn Met 
                245                 250                 255     


Lys Lys Glu Ser Leu Glu Ala Glu Ile Ala His Ser Gln Val Lys Gln 
            260                 265                 270         


Glu Ala Val Leu Leu His Glu Lys Leu Tyr Glu Leu Glu Ser His Arg 
        275                 280                 285             


Asp Gln Met Ile Ala Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala 
305                 310                 315                 320 


Ser Met Glu Arg Gln Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe 
                325                 330                 335     


Ile Glu Glu Ile Arg Gln Leu Asp Met Asp Leu Glu Glu His Gln Gly 
            340                 345                 350         


Glu Met Asn Gln Lys Tyr Lys Glu Leu Lys Lys Arg Glu Glu His Met 
        355                 360                 365             


Asp Thr Phe Ile Glu Thr Phe Glu Glu Thr Lys Asn Gln Glu Leu Lys 
    370                 375                 380                 


Arg Lys Ala Gln Ile Glu Ala Asn Ile Val Ala Leu Leu Glu His Cys 
385                 390                 395                 400 


Ser Arg Asn Ile Asn Arg Ile Glu Gln Ile Ser Ser Ile Thr Asn Gln 
                405                 410                 415     


Glu Leu Lys Met Met Gln Asp Asp Leu Asn Phe Lys Ser Thr Glu Val 
            420                 425                 430         


Gln Lys Ser Gln Ser Thr Ala Gln Asn Leu Thr Ser Asp Ile Gln Arg 
        435                 440                 445             


Leu Gln Leu Asp Leu Gln Lys Met Glu Leu Leu Glu Ser Lys Met Thr 
    450                 455                 460                 


Glu Glu Gln His Ser Leu Lys Ser Lys Ile Lys Gln Met Thr Thr Asp 
465                 470                 475                 480 


Leu Glu Ile Tyr Asn Asp Leu Pro Ala Leu Lys Ser Ser Gly Glu Glu 
                485                 490                 495     


Lys Ile Lys Lys Leu His Gln Glu Arg Met Ile Leu Ser Thr His Arg 
            500                 505                 510         


Asn Ala Phe Lys Lys Ile Met Glu Lys Gln Asn Ile Glu Tyr Glu Ala 
        515                 520                 525             


Leu Lys Thr Gln Leu Gln Glu Asn Glu Thr His Ser Gln Leu Thr Asn 
    530                 535                 540                 


Leu Glu Arg Lys Trp Gln His Leu Glu Gln Asn Asn Phe Ala Met Lys 
545                 550                 555                 560 


Glu Phe Ile Ala Thr Lys Ser Gln Glu Ser Asp Tyr Gln Pro Ile Lys 
                565                 570                 575     


Lys Asn Val Thr Lys Gln Ile Ala Glu Tyr Asn Lys Thr Ile Val Asp 
            580                 585                 590         


Ala Leu His Ser Thr Ser Gly Asn 
        595                 600 


<210>  5353
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT80__Homo_sapiens__NP_001177171

<400>  5353

Met Leu Arg Ser Thr Leu Ala Gln Gln Gly Thr Pro Val Tyr Ser Val 
1               5                   10                  15      


Ala Trp Gly Pro Asp Ser Glu Lys Val Leu Tyr Thr Ala Gly Lys Gln 
            20                  25                  30          


Leu Ile Ile Lys Pro Leu Gln Pro Asn Ala Lys Val Leu Gln Trp Lys 
        35                  40                  45              


Ala His Asp Gly Ile Ile Leu Lys Val Asp Trp Asn Ser Val Asn Asp 
    50                  55                  60                  


Leu Ile Leu Ser Ala Gly Glu Asp Cys Lys Tyr Lys Val Trp Asp Ser 
65                  70                  75                  80  


Tyr Gly Arg Pro Leu Tyr Asn Ser Gln Pro His Glu His Pro Ile Thr 
                85                  90                  95      


Ser Val Ala Trp Ala Pro Asp Gly Glu Leu Phe Ala Val Gly Ser Phe 
            100                 105                 110         


His Thr Leu Arg Leu Cys Asp Lys Thr Gly Trp Ser Tyr Ala Leu Glu 
        115                 120                 125             


Lys Pro Asn Thr Gly Ser Ile Phe Asn Ile Ala Trp Ser Ile Asp Gly 
    130                 135                 140                 


Thr Gln Ile Ala Gly Ala Cys Gly Asn Gly His Val Val Phe Ala His 
145                 150                 155                 160 


Val Val Glu Gln His Trp Glu Trp Lys Asn Phe Gln Val Thr Leu Thr 
                165                 170                 175     


Lys Arg Arg Ala Met Gln Val Arg Asn Val Leu Asn Asp Ala Val Asp 
            180                 185                 190         


Leu Leu Glu Phe Arg Asp Arg Val Ile Lys Ala Ser Leu Asn Tyr Ala 
        195                 200                 205             


His Leu Val Val Ser Thr Ser Leu Gln Cys Tyr Val Phe Ser Thr Lys 
    210                 215                 220                 


Asn Trp Asn Thr Pro Ile Ile Phe Asp Leu Lys Glu Gly Thr Val Ser 
225                 230                 235                 240 


Leu Ile Leu Gln Ala Glu Arg His Phe Leu Leu Val Asp Gly Ser Ser 
                245                 250                 255     


Ile Tyr Leu Tyr Ser Tyr Glu Gly Arg Phe Ile Ser Ser Pro Lys Phe 
            260                 265                 270         


Pro Gly Met Arg Thr Asp Ile Leu Asn Ala Gln Thr Val Ser Leu Ser 
        275                 280                 285             


Asn Asp Thr Ile Ala Ile Arg Asp Lys Ala Asp Glu Lys Ile Ile Phe 
    290                 295                 300                 


Leu Phe Glu Ala Ser Thr Gly Lys Pro Leu Gly Asp Gly Lys Phe Leu 
305                 310                 315                 320 


Ser His Lys Asn Glu Ile Leu Glu Ile Ala Leu Asp Gln Lys Gly Leu 
                325                 330                 335     


Thr Asn Asp Arg Lys Ile Ala Phe Ile Asp Lys Asn Arg Asp Leu Cys 
            340                 345                 350         


Ile Thr Ser Val Lys Arg Phe Gly Lys Glu Glu Gln Ile Ile Lys Leu 
        355                 360                 365             


Gly Thr Met Val His Thr Leu Ala Trp Asn Asp Thr Cys Asn Ile Leu 
    370                 375                 380                 


Cys Gly Leu Gln Asp Thr Arg Phe Ile Val Trp Tyr Tyr Pro Asn Thr 
385                 390                 395                 400 


Val Tyr Val Asp Arg Asp Ile Leu Pro Lys Thr Leu Tyr Glu Arg Asp 
                405                 410                 415     


Ala Ser Glu Phe Ser Lys Asn Pro His Ile Val Ser Phe Val Gly Asn 
            420                 425                 430         


Gln Val Thr Ile Arg Arg Ala Asp Gly Ser Leu Val His Ile Ser Ile 
        435                 440                 445             


Thr Pro Tyr Pro Ala Ile Leu His Glu Tyr Val Ser Ser Ser Lys Trp 
    450                 455                 460                 


Glu Asp Ala Val Arg Leu Cys Arg Phe Val Lys Glu Gln Thr Met Trp 
465                 470                 475                 480 


Ala Cys Leu Ala Ala Met Ala Val Ala Asn Arg Asp Met Thr Thr Ala 
                485                 490                 495     


Glu Ile Ala Tyr Ala Ala Ile Gly Glu Ile Asp Lys Val Gln Tyr Ile 
            500                 505                 510         


Asn Ser Ile Lys Asn Leu Pro Ser Lys Glu Ser Lys Met Ala His Ile 
        515                 520                 525             


Leu Leu Phe Ser Gly Asn Ile Gln Glu Ala Glu Ile Val Leu Leu Gln 
    530                 535                 540                 


Ala Gly Leu Val Tyr Gln Ala Ile Gln Ile Asn Ile Asn Leu Tyr Asn 
545                 550                 555                 560 


Trp Glu Arg Ala Leu Glu Leu Ala Val Lys Tyr Lys Thr His Val Asp 
                565                 570                 575     


Thr Val Leu Ala Tyr Arg Gln Lys Phe Leu Glu Thr Phe Gly Lys Gln 
            580                 585                 590         


Glu Thr Asn Lys Arg Tyr Leu His Tyr Ala Glu Gly Leu Gln Ile Asp 
        595                 600                 605             


Trp Glu Lys Ile Lys Ala Lys Ile Glu Met Glu Ile Thr Lys Glu Arg 
    610                 615                 620                 


Glu Gln Ser Ser Ser Ser Gln Ser Ser Lys Ser Ile Gly Leu Lys Pro 
625                 630                 635                 640 


<210>  5354
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFT88__Homo_sapiens__XP_005266603

<400>  5354

Met Lys Val Glu Ser Gly Met Lys Ile Lys Val His Asn Asn Ala Glu 
1               5                   10                  15      


Ser Glu Thr Ala Val Gly Phe Leu Glu Val Asp Gln Gly Cys Pro Ile 
            20                  25                  30          


Phe Gly Phe Pro Gly Pro His Arg Lys Lys Asn Cys Leu Gly Pro His 
        35                  40                  45              


Met Lys Phe Thr Asn Thr Lys Val Gln Met Met Gln Asn Val His Leu 
    50                  55                  60                  


Ala Pro Glu Thr Asp Glu Asp Asp Leu Tyr Ser Gly Tyr Asn Asp Tyr 
65                  70                  75                  80  


Asn Pro Ile Tyr Asp Ile Glu Glu Leu Glu Asn Asp Ala Ala Phe Gln 
                85                  90                  95      


Gln Ala Val Arg Thr Ser His Gly Arg Arg Pro Pro Ile Thr Ala Lys 
            100                 105                 110         


Ile Ser Ser Thr Ala Val Thr Arg Pro Ile Ala Thr Gly Tyr Gly Ser 
        115                 120                 125             


Lys Thr Ser Leu Ala Ser Ser Ile Gly Arg Pro Met Thr Gly Ala Ile 
    130                 135                 140                 


Gln Asp Gly Val Thr Arg Pro Met Thr Ala Val Arg Ala Ala Gly Phe 
145                 150                 155                 160 


Thr Lys Ala Ala Leu Arg Gly Ser Ala Phe Asp Pro Leu Ser Gln Ser 
                165                 170                 175     


Arg Gly Pro Ala Ser Pro Leu Glu Ala Lys Lys Lys Asp Ser Pro Glu 
            180                 185                 190         


Glu Lys Ile Lys Gln Leu Glu Lys Glu Val Asn Glu Leu Val Glu Glu 
        195                 200                 205             


Ser Cys Ile Ala Asn Ser Cys Gly Asp Leu Lys Leu Ala Leu Glu Lys 
    210                 215                 220                 


Ala Lys Asp Ala Gly Arg Lys Glu Arg Val Leu Val Arg Gln Arg Glu 
225                 230                 235                 240 


Gln Val Thr Thr Pro Glu Asn Ile Asn Leu Asp Leu Thr Tyr Ser Val 
                245                 250                 255     


Leu Phe Asn Leu Ala Ser Gln Tyr Ser Val Asn Glu Met Tyr Ala Glu 
            260                 265                 270         


Ala Leu Asn Thr Tyr Gln Val Ile Val Lys Asn Lys Met Phe Ser Asn 
        275                 280                 285             


Ala Gly Ile Leu Lys Met Asn Met Gly Asn Ile Tyr Leu Lys Gln Arg 
    290                 295                 300                 


Asn Tyr Ser Lys Ala Ile Lys Phe Tyr Arg Met Ala Leu Asp Gln Val 
305                 310                 315                 320 


Pro Ser Val Asn Lys Gln Met Arg Ile Lys Ile Met Gln Asn Ile Gly 
                325                 330                 335     


Val Thr Phe Ile Gln Ala Gly Gln Tyr Ser Asp Ala Ile Asn Ser Tyr 
            340                 345                 350         


Glu His Ile Met Ser Met Ala Pro Asn Leu Lys Ala Gly Tyr Asn Leu 
        355                 360                 365             


Thr Ile Cys Tyr Phe Ala Ile Gly Asp Arg Glu Lys Met Lys Lys Ala 
    370                 375                 380                 


Phe Gln Lys Leu Ile Thr Val Pro Leu Glu Ile Asp Glu Asp Lys Tyr 
385                 390                 395                 400 


Ile Ser Pro Ser Asp Asp Pro His Thr Asn Leu Val Thr Glu Ala Ile 
                405                 410                 415     


Lys Asn Asp His Leu Arg Gln Met Glu Arg Glu Arg Lys Ala Met Ala 
            420                 425                 430         


Glu Lys Tyr Ile Met Thr Ser Ala Lys Leu Ile Ala Pro Val Ile Glu 
        435                 440                 445             


Thr Ser Phe Ala Ala Gly Tyr Asp Trp Cys Val Glu Val Val Lys Ala 
    450                 455                 460                 


Ser Gln Tyr Val Glu Leu Ala Asn Asp Leu Glu Ile Asn Lys Ala Val 
465                 470                 475                 480 


Thr Tyr Leu Arg Gln Lys Asp Tyr Asn Gln Ala Val Glu Ile Leu Lys 
                485                 490                 495     


Val Leu Glu Lys Lys Asp Ser Arg Val Lys Ser Ala Ala Ala Thr Asn 
            500                 505                 510         


Leu Ser Ala Leu Tyr Tyr Met Gly Lys Asp Phe Ala Gln Ala Ser Ser 
        515                 520                 525             


Tyr Ala Asp Ile Ala Val Asn Ser Asp Arg Tyr Asn Pro Ala Ala Leu 
    530                 535                 540                 


Thr Asn Lys Gly Asn Thr Val Phe Ala Asn Gly Asp Tyr Glu Lys Ala 
545                 550                 555                 560 


Ala Glu Phe Tyr Lys Glu Ala Leu Arg Asn Asp Ser Ser Cys Thr Glu 
                565                 570                 575     


Ala Leu Tyr Asn Ile Gly Leu Thr Tyr Glu Lys Leu Asn Arg Leu Asp 
            580                 585                 590         


Glu Ala Leu Asp Cys Phe Leu Lys Leu His Ala Ile Leu Arg Asn Ser 
        595                 600                 605             


Ala Glu Val Leu Tyr Gln Ile Ala Asn Ile Tyr Glu Leu Met Glu Asn 
    610                 615                 620                 


Pro Ser Gln Ala Ile Glu Trp Leu Met Gln Val Val Ser Val Ile Pro 
625                 630                 635                 640 


Thr Asp Pro Gln Val Leu Ser Lys Leu Gly Glu Leu Tyr Asp Arg Glu 
                645                 650                 655     


Gly Asp Lys Ser Gln Ala Phe Gln Tyr Tyr Tyr Glu Ser Tyr Arg Tyr 
            660                 665                 670         


Phe Pro Cys Asn Ile Glu Val Ile Glu Trp Leu Gly Ala Tyr Tyr Ile 
        675                 680                 685             


Asp Thr Gln Phe Trp Glu Lys Ala Ile Gln Tyr Phe Glu Arg Ala Ser 
    690                 695                 700                 


Leu Ile Gln Pro Thr Gln Val Lys Trp Gln Leu Met Val Ala Ser Cys 
705                 710                 715                 720 


Phe Arg Arg Ser Gly Asn Tyr Gln Lys Ala Leu Asp Thr Tyr Lys Asp 
                725                 730                 735     


Thr His Arg Lys Phe Pro Glu Asn Val Glu Cys Leu Arg Phe Leu Val 
            740                 745                 750         


Arg Leu Cys Thr Asp Leu Gly Leu Lys Asp Ala Gln Glu Tyr Ala Arg 
        755                 760                 765             


Lys Leu Lys Arg Leu Glu Lys Met Lys Glu Ile Arg Glu Gln Arg Ile 
    770                 775                 780                 


Lys Ser Gly Arg Asp Gly Ser Gly Gly Ser Arg Gly Lys Arg Glu Gly 
785                 790                 795                 800 


Ser Ala Ser Gly Asp Ser Gly Gln Asn Tyr Ser Ala Ser Ser Lys Gly 
                805                 810                 815     


Glu Arg Leu Ser Ala Arg Leu Arg Ala Leu Pro Gly Thr Asn Glu Pro 
            820                 825                 830         


Tyr Glu Ser Ser Ser Asn Lys Glu Ile Asp Ala Ser Tyr Val Asp Pro 
        835                 840                 845             


Leu Gly Pro Gln Ile Glu Arg Pro Lys Thr Ala Ala Lys Lys Arg Ile 
    850                 855                 860                 


Asp Glu Asp Asp Phe Ala Asp Glu Glu Leu Gly Asp Asp Leu Leu Pro 
865                 870                 875                 880 


Glu 
    


<210>  5355
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGBP1__Homo_sapiens__NP_001542

<400>  5355

Met Ala Ala Glu Asp Glu Leu Gln Leu Pro Arg Leu Pro Glu Leu Phe 
1               5                   10                  15      


Glu Thr Gly Arg Gln Leu Leu Asp Glu Val Glu Val Ala Thr Glu Pro 
            20                  25                  30          


Ala Gly Ser Arg Ile Val Gln Glu Lys Val Phe Lys Gly Leu Asp Leu 
        35                  40                  45              


Leu Glu Lys Ala Ala Glu Met Leu Ser Gln Leu Asp Leu Phe Ser Arg 
    50                  55                  60                  


Asn Glu Asp Leu Glu Glu Ile Ala Ser Thr Asp Leu Lys Tyr Leu Leu 
65                  70                  75                  80  


Val Pro Ala Phe Gln Gly Ala Leu Thr Met Lys Gln Val Asn Pro Ser 
                85                  90                  95      


Lys Arg Leu Asp His Leu Gln Arg Ala Arg Glu His Phe Ile Asn Tyr 
            100                 105                 110         


Leu Thr Gln Cys His Cys Tyr His Val Ala Glu Phe Glu Leu Pro Lys 
        115                 120                 125             


Thr Met Asn Asn Ser Ala Glu Asn His Thr Ala Asn Ser Ser Met Ala 
    130                 135                 140                 


Tyr Pro Ser Leu Val Ala Met Ala Ser Gln Arg Gln Ala Lys Ile Gln 
145                 150                 155                 160 


Arg Tyr Lys Gln Lys Lys Glu Leu Glu His Arg Leu Ser Ala Met Lys 
                165                 170                 175     


Ser Ala Val Glu Ser Gly Gln Ala Asp Asp Glu Arg Val Arg Glu Tyr 
            180                 185                 190         


Tyr Leu Leu His Leu Gln Arg Trp Ile Asp Ile Ser Leu Glu Glu Ile 
        195                 200                 205             


Glu Ser Ile Asp Gln Glu Ile Lys Ile Leu Arg Glu Arg Asp Ser Ser 
    210                 215                 220                 


Arg Glu Ala Ser Thr Ser Asn Ser Ser Arg Gln Glu Arg Pro Pro Val 
225                 230                 235                 240 


Lys Pro Phe Ile Leu Thr Arg Asn Met Ala Gln Ala Lys Val Phe Gly 
                245                 250                 255     


Ala Gly Tyr Pro Ser Leu Pro Thr Met Thr Val Ser Asp Trp Tyr Glu 
            260                 265                 270         


Gln His Arg Lys Tyr Gly Ala Leu Pro Asp Gln Gly Ile Ala Lys Ala 
        275                 280                 285             


Ala Pro Glu Glu Phe Arg Lys Ala Ala Gln Gln Gln Glu Glu Gln Glu 
    290                 295                 300                 


Glu Lys Glu Glu Glu Asp Asp Glu Gln Thr Leu His Arg Ala Arg Glu 
305                 310                 315                 320 


Trp Asp Asp Trp Lys Asp Thr His Pro Arg Gly Tyr Gly Asn Arg Gln 
                325                 330                 335     


Asn Met Gly 
            


<210>  5356
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGDCC3__Homo_sapiens__NP_004875

<400>  5356

Met Ala Val Gln Arg Ala Ala Ser Pro Arg Arg Pro Pro Ala Pro Leu 
1               5                   10                  15      


Trp Pro Arg Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Pro Ala Pro 
            20                  25                  30          


Ser Glu Gly Leu Gly His Ser Ala Glu Leu Ala Phe Ala Val Glu Pro 
        35                  40                  45              


Ser Asp Asp Val Ala Val Pro Gly Gln Pro Ile Val Leu Asp Cys Arg 
    50                  55                  60                  


Val Glu Gly Thr Pro Pro Val Arg Ile Thr Trp Arg Lys Asn Gly Val 
65                  70                  75                  80  


Glu Leu Pro Glu Ser Thr His Ser Thr Leu Leu Ala Asn Gly Ser Leu 
                85                  90                  95      


Met Ile Arg His Phe Arg Leu Glu Pro Gly Gly Ser Pro Ser Asp Glu 
            100                 105                 110         


Gly Asp Tyr Glu Cys Val Ala Gln Asn Arg Phe Gly Leu Val Val Ser 
        115                 120                 125             


Arg Lys Ala Arg Ile Gln Ala Ala Thr Met Ser Asp Phe His Val His 
    130                 135                 140                 


Pro Gln Ala Thr Val Gly Glu Glu Gly Gly Val Ala Arg Phe Gln Cys 
145                 150                 155                 160 


Gln Ile His Gly Leu Pro Lys Pro Leu Ile Thr Trp Glu Lys Asn Arg 
                165                 170                 175     


Val Pro Ile Asp Thr Asp Asn Glu Arg Tyr Thr Leu Leu Pro Lys Gly 
            180                 185                 190         


Val Leu Gln Ile Thr Gly Leu Arg Ala Glu Asp Gly Gly Ile Phe His 
        195                 200                 205             


Cys Val Ala Ser Asn Ile Ala Ser Ile Arg Ile Ser His Gly Ala Arg 
    210                 215                 220                 


Leu Thr Val Ser Gly Ser Gly Ser Gly Ala Tyr Lys Glu Pro Ala Ile 
225                 230                 235                 240 


Leu Val Gly Pro Glu Asn Leu Thr Leu Thr Val His Gln Thr Ala Val 
                245                 250                 255     


Leu Glu Cys Val Ala Thr Gly Asn Pro Arg Pro Ile Val Ser Trp Ser 
            260                 265                 270         


Arg Leu Asp Gly Arg Pro Ile Gly Val Glu Gly Ile Gln Val Leu Gly 
        275                 280                 285             


Thr Gly Asn Leu Ile Ile Ser Asp Val Thr Val Gln His Ser Gly Val 
    290                 295                 300                 


Tyr Val Cys Ala Ala Asn Arg Pro Gly Thr Arg Val Arg Arg Thr Ala 
305                 310                 315                 320 


Gln Gly Arg Leu Val Val Gln Ala Pro Ala Glu Phe Val Gln His Pro 
                325                 330                 335     


Gln Ser Ile Ser Arg Pro Ala Gly Thr Thr Ala Met Phe Thr Cys Gln 
            340                 345                 350         


Ala Gln Gly Glu Pro Pro Pro His Val Thr Trp Leu Lys Asn Gly Gln 
        355                 360                 365             


Val Leu Gly Pro Gly Gly His Val Arg Leu Lys Asn Asn Asn Ser Thr 
    370                 375                 380                 


Leu Thr Ile Ser Gly Ile Gly Pro Glu Asp Glu Ala Ile Tyr Gln Cys 
385                 390                 395                 400 


Val Ala Glu Asn Ser Ala Gly Ser Ser Gln Ala Ser Ala Arg Leu Thr 
                405                 410                 415     


Val Leu Trp Ala Glu Gly Leu Pro Gly Pro Pro Arg Asn Val Arg Ala 
            420                 425                 430         


Val Ser Val Ser Ser Thr Glu Val Arg Val Ser Trp Ser Glu Pro Leu 
        435                 440                 445             


Ala Asn Thr Lys Glu Ile Ile Gly Tyr Val Leu His Ile Arg Lys Ala 
    450                 455                 460                 


Ala Asp Pro Pro Glu Leu Glu Tyr Gln Glu Ala Val Ser Lys Ser Thr 
465                 470                 475                 480 


Phe Gln His Leu Val Ser Asp Leu Glu Pro Ser Thr Ala Tyr Ser Phe 
                485                 490                 495     


Tyr Ile Lys Ala Tyr Thr Pro Arg Gly Ala Ser Ser Ala Ser Val Pro 
            500                 505                 510         


Thr Leu Ala Ser Thr Leu Gly Glu Ala Pro Ala Pro Pro Pro Leu Ser 
        515                 520                 525             


Val Arg Val Leu Gly Ser Ser Ser Leu Gln Leu Leu Trp Glu Pro Trp 
    530                 535                 540                 


Pro Arg Leu Ala Gln His Glu Gly Gly Phe Lys Leu Phe Tyr Arg Pro 
545                 550                 555                 560 


Ala Ser Lys Thr Ser Phe Thr Gly Pro Ile Leu Leu Pro Gly Thr Val 
                565                 570                 575     


Ser Ser Tyr Asn Leu Ser Gln Leu Asp Pro Thr Ala Val Tyr Glu Val 
            580                 585                 590         


Lys Leu Leu Ala Tyr Asn Gln His Gly Asp Gly Asn Ala Thr Val Arg 
        595                 600                 605             


Phe Val Ser Leu Arg Gly Ala Ser Glu Arg Thr Ala Leu Ser Pro Pro 
    610                 615                 620                 


Cys Asp Cys Arg Lys Glu Glu Ala Ala Asn Gln Thr Ser Thr Thr Gly 
625                 630                 635                 640 


Ile Val Ile Gly Ile His Ile Gly Val Thr Cys Ile Ile Phe Cys Val 
                645                 650                 655     


Leu Phe Leu Leu Phe Gly Gln Arg Gly Arg Val Leu Leu Cys Lys Asp 
            660                 665                 670         


Val Glu Asn Gln Leu Ser Pro Pro Gln Gly Pro Arg Ser Gln Arg Asp 
        675                 680                 685             


Pro Gly Ile Leu Ala Leu Asn Gly Ala Arg Arg Gly Gln Arg Gly Gln 
    690                 695                 700                 


Leu Gly Arg Asp Glu Lys Arg Val Asp Met Lys Glu Leu Glu Gln Leu 
705                 710                 715                 720 


Phe Pro Pro Ala Ser Ala Ala Gly Gln Pro Asp Pro Arg Pro Thr Gln 
                725                 730                 735     


Asp Pro Ala Ala Pro Ala Pro Cys Glu Glu Thr Gln Leu Ser Val Leu 
            740                 745                 750         


Pro Leu Gln Gly Cys Gly Leu Met Glu Gly Lys Thr Thr Glu Ala Lys 
        755                 760                 765             


Thr Thr Glu Ala Thr Ala Pro Cys Ala Gly Leu Ala Ala Ala Pro Pro 
    770                 775                 780                 


Pro Pro Asp Gly Gly Pro Gly Leu Leu Ser Glu Gly Gln Ala Ser Arg 
785                 790                 795                 800 


Pro Ala Ala Ala Arg Val Thr Gln Pro Ala His Ser Glu Gln 
                805                 810                 


<210>  5357
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1__Homo_sapiens__NP_000609

<400>  5357

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  5358
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R__Homo_sapiens__NP_000866

<400>  5358

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


<210>  5359
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2BP1__Homo_sapiens__NP_001153895

<400>  5359

Met Asn Lys Leu Tyr Ile Gly Asn Leu Asn Glu Ser Val Thr Pro Ala 
1               5                   10                  15      


Asp Leu Glu Lys Val Phe Ala Glu His Lys Ile Ser Tyr Ser Gly Gln 
            20                  25                  30          


Phe Leu Val Lys Ser Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu His 
        35                  40                  45              


Trp Ala Met Lys Ala Ile Glu Thr Phe Ser Gly Lys Val Glu Leu Gln 
    50                  55                  60                  


Gly Lys Arg Leu Glu Ile Glu His Ser Val Pro Lys Lys Gln Arg Ser 
65                  70                  75                  80  


Arg Lys Ile Gln Ile Arg Asn Ile Pro Pro Gln Leu Arg Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Ala Gln Tyr Gly Thr Val Glu Asn Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Glu Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Asn 
        115                 120                 125             


Arg Glu Gln Thr Arg Gln Ala Asp Glu Val Pro Leu Lys Ile Leu Ala 
    130                 135                 140                 


His Asn Asn Phe Val Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu 
145                 150                 155                 160 


Lys Lys Val Glu Gln Asp Thr Glu Thr Lys Ile Thr Ile Ser Ser Leu 
                165                 170                 175     


Gln Asp Leu Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly 
            180                 185                 190         


Ala Ile Glu Asn Cys Cys Arg Ala Glu Gln Glu Ile Met Lys Lys Val 
        195                 200                 205             


Arg Glu Ala Tyr Glu Asn Asp Val Ala Ala Met Ser Leu Gln Ser His 
    210                 215                 220                 


Leu Ile Pro Gly Leu Asn Leu Ala Ala Val Gly Leu Phe Pro Ala Ser 
225                 230                 235                 240 


Ser Ser Ala Val Pro Pro Pro Pro Ser Ser Val Thr Gly Ala Ala Pro 
                245                 250                 255     


Tyr Ser Ser Phe Met Gln Ala Pro Glu Gln Glu Met Val Gln Val Phe 
            260                 265                 270         


Ile Pro Ala Gln Ala Val Gly Ala Ile Ile Gly Lys Lys Gly Gln His 
        275                 280                 285             


Ile Lys Gln Leu Ser Arg Phe Ala Ser Ala Ser Ile Lys Ile Ala Pro 
    290                 295                 300                 


Pro Glu Thr Pro Asp Ser Lys Val Arg Met Val Ile Ile Thr Gly Pro 
305                 310                 315                 320 


Pro Glu Ala Gln Phe Lys Ala Gln Gly Arg Ile Tyr Gly Lys Leu Lys 
                325                 330                 335     


Glu Glu Asn Phe Phe Gly Pro Lys Glu Glu Val Lys Leu Glu Thr His 
            340                 345                 350         


Ile Arg Val Pro Ala Ser Ala Ala Gly Arg Val Ile Gly Lys Gly Gly 
        355                 360                 365             


Lys Thr Val Asn Glu Leu Gln Asn Leu Thr Ala Ala Glu Val Val Val 
    370                 375                 380                 


Pro Arg Asp Gln Thr Pro Asp Glu Asn Asp Gln Val Ile Val Lys Ile 
385                 390                 395                 400 


Ile Gly His Phe Tyr Ala Ser Gln Met Ala Gln Arg Lys Ile Arg Asp 
                405                 410                 415     


Ile Leu Ala Gln Val Lys Gln Gln His Gln Lys Gly Gln Ser Asn Gln 
            420                 425                 430         


Ala Gln Ala Arg Arg Lys 
        435             


<210>  5360
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2BP2__Homo_sapiens__NP_001007226

<400>  5360

Met Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Pro Ala Val Thr Ala 
1               5                   10                  15      


Asp Asp Leu Arg Gln Leu Phe Gly Asp Arg Lys Leu Pro Leu Ala Gly 
            20                  25                  30          


Gln Val Leu Leu Lys Ser Gly Tyr Ala Phe Val Asp Tyr Pro Asp Gln 
        35                  40                  45              


Asn Trp Ala Ile Arg Ala Ile Glu Thr Leu Ser Gly Lys Val Glu Leu 
    50                  55                  60                  


His Gly Lys Ile Met Glu Val Asp Tyr Ser Val Ser Lys Lys Leu Arg 
65                  70                  75                  80  


Ser Arg Lys Ile Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu 
                85                  90                  95      


Val Leu Asp Gly Leu Leu Ala Gln Tyr Gly Thr Val Glu Asn Val Glu 
            100                 105                 110         


Gln Val Asn Thr Asp Thr Glu Thr Ala Val Val Asn Val Thr Tyr Ala 
        115                 120                 125             


Thr Arg Glu Glu Ala Lys Ile Ala Met Glu Lys Leu Ser Gly His Gln 
    130                 135                 140                 


Phe Glu Asn Tyr Ser Phe Lys Ile Ser Tyr Ile Pro Asp Glu Glu Val 
145                 150                 155                 160 


Ser Ser Pro Ser Pro Pro Gln Arg Ala Gln Arg Gly Asp His Ser Ser 
                165                 170                 175     


Arg Glu Gln Gly His Ala Pro Gly Gly Thr Ser Gln Ala Arg Gln Ile 
            180                 185                 190         


Asp Phe Pro Leu Arg Ile Leu Val Pro Thr Gln Phe Val Gly Ala Ile 
        195                 200                 205             


Ile Gly Lys Glu Gly Leu Thr Ile Lys Asn Ile Thr Lys Gln Thr Gln 
    210                 215                 220                 


Ser Arg Val Asp Ile His Arg Lys Glu Asn Ser Gly Ala Ala Glu Lys 
225                 230                 235                 240 


Pro Val Thr Ile His Ala Thr Pro Glu Gly Thr Ser Glu Ala Cys Arg 
                245                 250                 255     


Met Ile Leu Glu Ile Met Gln Lys Glu Ala Asp Glu Thr Lys Leu Ala 
            260                 265                 270         


Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Gly Leu Val Gly Arg 
        275                 280                 285             


Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu His Glu Thr 
    290                 295                 300                 


Gly Thr Lys Ile Thr Ile Ser Ser Leu Gln Asp Leu Ser Ile Tyr Asn 
305                 310                 315                 320 


Pro Glu Arg Thr Ile Thr Val Lys Gly Thr Val Glu Ala Cys Ala Ser 
                325                 330                 335     


Ala Glu Ile Glu Ile Met Lys Lys Leu Arg Glu Ala Phe Glu Asn Asp 
            340                 345                 350         


Met Leu Ala Val Asn Thr His Ser Gly Tyr Phe Ser Ser Leu Tyr Pro 
        355                 360                 365             


His His Gln Phe Gly Pro Phe Pro His His His Ser Tyr Pro Glu Gln 
    370                 375                 380                 


Glu Ile Val Asn Leu Phe Ile Pro Thr Gln Ala Val Gly Ala Ile Ile 
385                 390                 395                 400 


Gly Lys Lys Gly Ala His Ile Lys Gln Leu Ala Arg Phe Ala Gly Ala 
                405                 410                 415     


Ser Ile Lys Ile Ala Pro Ala Glu Gly Pro Asp Val Ser Glu Arg Met 
            420                 425                 430         


Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe Lys Ala Gln Gly Arg 
        435                 440                 445             


Ile Phe Gly Lys Leu Lys Glu Glu Asn Phe Phe Asn Pro Lys Glu Glu 
    450                 455                 460                 


Val Lys Leu Glu Ala His Ile Arg Val Pro Ser Ser Thr Ala Gly Arg 
465                 470                 475                 480 


Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu Leu Gln Asn Leu Thr 
                485                 490                 495     


Ser Ala Glu Val Ile Val Pro Arg Asp Gln Thr Pro Asp Glu Asn Glu 
            500                 505                 510         


Glu Val Ile Val Arg Ile Ile Gly His Phe Phe Ala Ser Gln Thr Ala 
        515                 520                 525             


Gln Arg Lys Ile Arg Glu Ile Val Gln Gln Val Lys Gln Gln Glu Gln 
    530                 535                 540                 


Lys Tyr Pro Gln Gly Val Ala Ser Gln Arg Ser Lys 
545                 550                 555     


<210>  5361
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2BP3__Homo_sapiens__NP_006538

<400>  5361

Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Glu Asn Ala Ala Pro Ser 
1               5                   10                  15      


Asp Leu Glu Ser Ile Phe Lys Asp Ala Lys Ile Pro Val Ser Gly Pro 
            20                  25                  30          


Phe Leu Val Lys Thr Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu Ser 
        35                  40                  45              


Trp Ala Leu Lys Ala Ile Glu Ala Leu Ser Gly Lys Ile Glu Leu His 
    50                  55                  60                  


Gly Lys Pro Ile Glu Val Glu His Ser Val Pro Lys Arg Gln Arg Ile 
65                  70                  75                  80  


Arg Lys Leu Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Val Gln Tyr Gly Val Val Glu Ser Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Asp Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Ser 
        115                 120                 125             


Lys Asp Gln Ala Arg Gln Ala Leu Asp Lys Leu Asn Gly Phe Gln Leu 
    130                 135                 140                 


Glu Asn Phe Thr Leu Lys Val Ala Tyr Ile Pro Asp Glu Met Ala Ala 
145                 150                 155                 160 


Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly Leu Gly Gln 
                165                 170                 175     


Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser Lys Gln Lys 
            180                 185                 190         


Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln Phe Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr Ser Ala Ala 
                245                 250                 255     


Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln Asp Ile Lys 
            260                 265                 270         


Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu Gln 
    290                 295                 300                 


Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val Glu Thr Cys 
                325                 330                 335     


Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu Ser Tyr Glu 
            340                 345                 350         


Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly Met Pro Pro 
    370                 375                 380                 


Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr Pro Gln Phe 
385                 390                 395                 400 


Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro Ala Leu Ser 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu Ala Pro Asp 
        435                 440                 445             


Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu Asn Phe Val 
465                 470                 475                 480 


Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg Val Pro Ser 
                485                 490                 495     


Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly His Phe Tyr 
    530                 535                 540                 


Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu Thr Gln Val 
545                 550                 555                 560 


Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro Pro Gln Ser 
                565                 570                 575     


Arg Arg Lys 
            


<210>  5362
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2__Homo_sapiens__NP_001121070

<400>  5362

Met Val Ser Pro Asp Pro Gln Ile Ile Val Val Ala Pro Glu Thr Glu 
1               5                   10                  15      


Leu Ala Ser Met Gln Val Gln Arg Thr Glu Asp Gly Val Thr Ile Ile 
            20                  25                  30          


Gln Ile Phe Trp Val Gly Arg Lys Gly Glu Leu Leu Arg Arg Thr Pro 
        35                  40                  45              


Val Ser Ser Ala Met Gln Thr Pro Met Gly Ile Pro Met Gly Lys Ser 
    50                  55                  60                  


Met Leu Val Leu Leu Thr Phe Leu Ala Phe Ala Ser Cys Cys Ile Ala 
65                  70                  75                  80  


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                85                  90                  95      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            100                 105                 110         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        115                 120                 125             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    130                 135                 140                 


Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 
145                 150                 155                 160 


Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 
                165                 170                 175     


Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 
            180                 185                 190         


Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 
        195                 200                 205             


Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His 
    210                 215                 220                 


Gly Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 
225                 230                 235     


<210>  5363
<211>  2491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2R__Homo_sapiens__NP_000867

<400>  5363

Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala 
1               5                   10                  15      


Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val 
            20                  25                  30          


Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu 
        35                  40                  45              


Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr 
    50                  55                  60                  


Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser 
65                  70                  75                  80  


Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val 
                85                  90                  95      


Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn 
            100                 105                 110         


Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser 
        115                 120                 125             


Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val 
    130                 135                 140                 


Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val 
                165                 170                 175     


Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu 
            180                 185                 190         


Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe 
        195                 200                 205             


Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln 
    210                 215                 220                 


Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His 
225                 230                 235                 240 


Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Leu Val Arg 
                245                 250                 255     


Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu 
            260                 265                 270         


Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys 
        275                 280                 285             


Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser 
    290                 295                 300                 


Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg 
305                 310                 315                 320 


Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp 
                325                 330                 335     


Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr 
            340                 345                 350         


Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu 
        355                 360                 365             


Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val 
    370                 375                 380                 


Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn 
385                 390                 395                 400 


Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly 
                405                 410                 415     


Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe 
            420                 425                 430         


Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe 
        435                 440                 445             


Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr 
    450                 455                 460                 


Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly 
465                 470                 475                 480 


Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu 
                485                 490                 495     


Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Glu Lys Lys 
            500                 505                 510         


His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala 
        515                 520                 525             


Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly 
    530                 535                 540                 


Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly 
545                 550                 555                 560 


Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys 
                565                 570                 575     


Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu 
            580                 585                 590         


Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu 
        595                 600                 605             


Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly 
    610                 615                 620                 


Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu 
625                 630                 635                 640 


Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys 
                645                 650                 655     


Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys 
            660                 665                 670         


Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr 
        675                 680                 685             


Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met 
    690                 695                 700                 


Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His 
705                 710                 715                 720 


Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly 
                725                 730                 735     


Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe 
            740                 745                 750         


Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val 
        755                 760                 765             


Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala 
    770                 775                 780                 


Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser 
785                 790                 795                 800 


Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro 
                805                 810                 815     


Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met 
            820                 825                 830         


Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Val Ser Ile Ser 
        835                 840                 845             


Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser 
    850                 855                 860                 


Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly 
865                 870                 875                 880 


Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly 
                885                 890                 895     


Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val 
            900                 905                 910         


Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr 
        915                 920                 925             


Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val 
    930                 935                 940                 


Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly 
945                 950                 955                 960 


Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys 
                965                 970                 975     


Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln 
            980                 985                 990         


Thr Glu Glu Leu Lys Asn Trp Lys  Pro Ala Arg Pro Val  Gly Ile Glu 
        995                 1000                 1005             


Lys Ser  Leu Gln Leu Ser Thr  Glu Gly Phe Ile Thr  Leu Thr Tyr 
    1010                 1015                 1020             


Lys Gly  Pro Leu Ser Ala Lys  Gly Thr Ala Asp Ala  Phe Ile Val 
    1025                 1030                 1035             


Arg Phe  Val Cys Asn Asp Asp  Val Tyr Ser Gly Pro  Leu Lys Phe 
    1040                 1045                 1050             


Leu His  Gln Asp Ile Asp Ser  Gly Gln Gly Ile Arg  Asn Thr Tyr 
    1055                 1060                 1065             


Phe Glu  Phe Glu Thr Ala Leu  Ala Cys Val Pro Ser  Pro Val Asp 
    1070                 1075                 1080             


Cys Gln  Val Thr Asp Leu Ala  Gly Asn Glu Tyr Asp  Leu Thr Gly 
    1085                 1090                 1095             


Leu Ser  Thr Val Arg Lys Pro  Trp Thr Ala Val Asp  Thr Ser Val 
    1100                 1105                 1110             


Asp Gly  Arg Lys Arg Thr Phe  Tyr Leu Ser Val Cys  Asn Pro Leu 
    1115                 1120                 1125             


Pro Tyr  Ile Pro Gly Cys Gln  Gly Ser Ala Val Gly  Ser Cys Leu 
    1130                 1135                 1140             


Val Ser  Glu Gly Asn Ser Trp  Asn Leu Gly Val Val  Gln Met Ser 
    1145                 1150                 1155             


Pro Gln  Ala Ala Ala Asn Gly  Ser Leu Ser Ile Met  Tyr Val Asn 
    1160                 1165                 1170             


Gly Asp  Lys Cys Gly Asn Gln  Arg Phe Ser Thr Arg  Ile Thr Phe 
    1175                 1180                 1185             


Glu Cys  Ala Gln Ile Ser Gly  Ser Pro Ala Phe Gln  Leu Gln Asp 
    1190                 1195                 1200             


Gly Cys  Glu Tyr Val Phe Ile  Trp Arg Thr Val Glu  Ala Cys Pro 
    1205                 1210                 1215             


Val Val  Arg Val Glu Gly Asp  Asn Cys Glu Val Lys  Asp Pro Arg 
    1220                 1225                 1230             


His Gly  Asn Leu Tyr Asp Leu  Lys Pro Leu Gly Leu  Asn Asp Thr 
    1235                 1240                 1245             


Ile Val  Ser Ala Gly Glu Tyr  Thr Tyr Tyr Phe Arg  Val Cys Gly 
    1250                 1255                 1260             


Lys Leu  Ser Ser Asp Val Cys  Pro Thr Ser Asp Lys  Ser Lys Val 
    1265                 1270                 1275             


Val Ser  Ser Cys Gln Glu Lys  Arg Glu Pro Gln Gly  Phe His Lys 
    1280                 1285                 1290             


Val Ala  Gly Leu Leu Thr Gln  Lys Leu Thr Tyr Glu  Asn Gly Leu 
    1295                 1300                 1305             


Leu Lys  Met Asn Phe Thr Gly  Gly Asp Thr Cys His  Lys Val Tyr 
    1310                 1315                 1320             


Gln Arg  Ser Thr Ala Ile Phe  Phe Tyr Cys Asp Arg  Gly Thr Gln 
    1325                 1330                 1335             


Arg Pro  Val Phe Leu Lys Glu  Thr Ser Asp Cys Ser  Tyr Leu Phe 
    1340                 1345                 1350             


Glu Trp  Arg Thr Gln Tyr Ala  Cys Pro Pro Phe Asp  Leu Thr Glu 
    1355                 1360                 1365             


Cys Ser  Phe Lys Asp Gly Ala  Gly Asn Ser Phe Asp  Leu Ser Ser 
    1370                 1375                 1380             


Leu Ser  Arg Tyr Ser Asp Asn  Trp Glu Ala Ile Thr  Gly Thr Gly 
    1385                 1390                 1395             


Asp Pro  Glu His Tyr Leu Ile  Asn Val Cys Lys Ser  Leu Ala Pro 
    1400                 1405                 1410             


Gln Ala  Gly Thr Glu Pro Cys  Pro Pro Glu Ala Ala  Ala Cys Leu 
    1415                 1420                 1425             


Leu Gly  Gly Ser Lys Pro Val  Asn Leu Gly Arg Val  Arg Asp Gly 
    1430                 1435                 1440             


Pro Gln  Trp Arg Asp Gly Ile  Ile Val Leu Lys Tyr  Val Asp Gly 
    1445                 1450                 1455             


Asp Leu  Cys Pro Asp Gly Ile  Arg Lys Lys Ser Thr  Thr Ile Arg 
    1460                 1465                 1470             


Phe Thr  Cys Ser Glu Ser Gln  Val Asn Ser Arg Pro  Met Phe Ile 
    1475                 1480                 1485             


Ser Ala  Val Glu Asp Cys Glu  Tyr Thr Phe Ala Trp  Pro Thr Ala 
    1490                 1495                 1500             


Thr Ala  Cys Pro Met Lys Ser  Asn Glu His Asp Asp  Cys Gln Val 
    1505                 1510                 1515             


Thr Asn  Pro Ser Thr Gly His  Leu Phe Asp Leu Ser  Ser Leu Ser 
    1520                 1525                 1530             


Gly Arg  Ala Gly Phe Thr Ala  Ala Tyr Ser Glu Lys  Gly Leu Val 
    1535                 1540                 1545             


Tyr Met  Ser Ile Cys Gly Glu  Asn Glu Asn Cys Pro  Pro Gly Val 
    1550                 1555                 1560             


Gly Ala  Cys Phe Gly Gln Thr  Arg Ile Ser Val Gly  Lys Ala Asn 
    1565                 1570                 1575             


Lys Arg  Leu Arg Tyr Val Asp  Gln Val Leu Gln Leu  Val Tyr Lys 
    1580                 1585                 1590             


Asp Gly  Ser Pro Cys Pro Ser  Lys Ser Gly Leu Ser  Tyr Lys Ser 
    1595                 1600                 1605             


Val Ile  Ser Phe Val Cys Arg  Pro Glu Ala Gly Pro  Thr Asn Arg 
    1610                 1615                 1620             


Pro Met  Leu Ile Ser Leu Asp  Lys Gln Thr Cys Thr  Leu Phe Phe 
    1625                 1630                 1635             


Ser Trp  His Thr Pro Leu Ala  Cys Glu Gln Ala Thr  Glu Cys Ser 
    1640                 1645                 1650             


Val Arg  Asn Gly Ser Ser Ile  Val Asp Leu Ser Pro  Leu Ile His 
    1655                 1660                 1665             


Arg Thr  Gly Gly Tyr Glu Ala  Tyr Asp Glu Ser Glu  Asp Asp Ala 
    1670                 1675                 1680             


Ser Asp  Thr Asn Pro Asp Phe  Tyr Ile Asn Ile Cys  Gln Pro Leu 
    1685                 1690                 1695             


Asn Pro  Met His Gly Val Pro  Cys Pro Ala Gly Ala  Ala Val Cys 
    1700                 1705                 1710             


Lys Val  Pro Ile Asp Gly Pro  Pro Ile Asp Ile Gly  Arg Val Ala 
    1715                 1720                 1725             


Gly Pro  Pro Ile Leu Asn Pro  Ile Ala Asn Glu Ile  Tyr Leu Asn 
    1730                 1735                 1740             


Phe Glu  Ser Ser Thr Pro Cys  Leu Ala Asp Lys His  Phe Asn Tyr 
    1745                 1750                 1755             


Thr Ser  Leu Ile Ala Phe His  Cys Lys Arg Gly Val  Ser Met Gly 
    1760                 1765                 1770             


Thr Pro  Lys Leu Leu Arg Thr  Ser Glu Cys Asp Phe  Val Phe Glu 
    1775                 1780                 1785             


Trp Glu  Thr Pro Val Val Cys  Pro Asp Glu Val Arg  Met Asp Gly 
    1790                 1795                 1800             


Cys Thr  Leu Thr Asp Glu Gln  Leu Leu Tyr Ser Phe  Asn Leu Ser 
    1805                 1810                 1815             


Ser Leu  Ser Thr Ser Thr Phe  Lys Val Thr Arg Asp  Ser Arg Thr 
    1820                 1825                 1830             


Tyr Ser  Val Gly Val Cys Thr  Phe Ala Val Gly Pro  Glu Gln Gly 
    1835                 1840                 1845             


Gly Cys  Lys Asp Gly Gly Val  Cys Leu Leu Ser Gly  Thr Lys Gly 
    1850                 1855                 1860             


Ala Ser  Phe Gly Arg Leu Gln  Ser Met Lys Leu Asp  Tyr Arg His 
    1865                 1870                 1875             


Gln Asp  Glu Ala Val Val Leu  Ser Tyr Val Asn Gly  Asp Arg Cys 
    1880                 1885                 1890             


Pro Pro  Glu Thr Asp Asp Gly  Val Pro Cys Val Phe  Pro Phe Ile 
    1895                 1900                 1905             


Phe Asn  Gly Lys Ser Tyr Glu  Glu Cys Ile Ile Glu  Ser Arg Ala 
    1910                 1915                 1920             


Lys Leu  Trp Cys Ser Thr Thr  Ala Asp Tyr Asp Arg  Asp His Glu 
    1925                 1930                 1935             


Trp Gly  Phe Cys Arg His Ser  Asn Ser Tyr Arg Thr  Ser Ser Ile 
    1940                 1945                 1950             


Ile Phe  Lys Cys Asp Glu Asp  Glu Asp Ile Gly Arg  Pro Gln Val 
    1955                 1960                 1965             


Phe Ser  Glu Val Arg Gly Cys  Asp Val Thr Phe Glu  Trp Lys Thr 
    1970                 1975                 1980             


Lys Val  Val Cys Pro Pro Lys  Lys Leu Glu Cys Lys  Phe Val Gln 
    1985                 1990                 1995             


Lys His  Lys Thr Tyr Asp Leu  Arg Leu Leu Ser Ser  Leu Thr Gly 
    2000                 2005                 2010             


Ser Trp  Ser Leu Val His Asn  Gly Val Ser Tyr Tyr  Ile Asn Leu 
    2015                 2020                 2025             


Cys Gln  Lys Ile Tyr Lys Gly  Pro Leu Gly Cys Ser  Glu Arg Ala 
    2030                 2035                 2040             


Ser Ile  Cys Arg Arg Thr Thr  Thr Gly Asp Val Gln  Val Leu Gly 
    2045                 2050                 2055             


Leu Val  His Thr Gln Lys Leu  Gly Val Ile Gly Asp  Lys Val Val 
    2060                 2065                 2070             


Val Thr  Tyr Ser Lys Gly Tyr  Pro Cys Gly Gly Asn  Lys Thr Ala 
    2075                 2080                 2085             


Ser Ser  Val Ile Glu Leu Thr  Cys Thr Lys Thr Val  Gly Arg Pro 
    2090                 2095                 2100             


Ala Phe  Lys Arg Phe Asp Ile  Asp Ser Cys Thr Tyr  Tyr Phe Ser 
    2105                 2110                 2115             


Trp Asp  Ser Arg Ala Ala Cys  Ala Val Lys Pro Gln  Glu Val Gln 
    2120                 2125                 2130             


Met Val  Asn Gly Thr Ile Thr  Asn Pro Ile Asn Gly  Lys Ser Phe 
    2135                 2140                 2145             


Ser Leu  Gly Asp Ile Tyr Phe  Lys Leu Phe Arg Ala  Ser Gly Asp 
    2150                 2155                 2160             


Met Arg  Thr Asn Gly Asp Asn  Tyr Leu Tyr Glu Ile  Gln Leu Ser 
    2165                 2170                 2175             


Ser Ile  Thr Ser Ser Arg Asn  Pro Ala Cys Ser Gly  Ala Asn Ile 
    2180                 2185                 2190             


Cys Gln  Val Lys Pro Asn Asp  Gln His Phe Ser Arg  Lys Val Gly 
    2195                 2200                 2205             


Thr Ser  Asp Lys Thr Lys Tyr  Tyr Leu Gln Asp Gly  Asp Leu Asp 
    2210                 2215                 2220             


Val Val  Phe Ala Ser Ser Ser  Lys Cys Gly Lys Asp  Lys Thr Lys 
    2225                 2230                 2235             


Ser Val  Ser Ser Thr Ile Phe  Phe His Cys Asp Pro  Leu Val Glu 
    2240                 2245                 2250             


Asp Gly  Ile Pro Glu Phe Ser  His Glu Thr Ala Asp  Cys Gln Tyr 
    2255                 2260                 2265             


Leu Phe  Ser Trp Tyr Thr Ser  Ala Val Cys Pro Leu  Gly Val Gly 
    2270                 2275                 2280             


Phe Asp  Ser Glu Asn Pro Gly  Asp Asp Gly Gln Met  His Lys Gly 
    2285                 2290                 2295             


Leu Ser  Glu Arg Ser Gln Ala  Val Gly Ala Val Leu  Ser Leu Leu 
    2300                 2305                 2310             


Leu Val  Ala Leu Thr Cys Cys  Leu Leu Ala Leu Leu  Leu Tyr Lys 
    2315                 2320                 2325             


Lys Glu  Arg Arg Glu Thr Val  Ile Ser Lys Leu Thr  Thr Cys Cys 
    2330                 2335                 2340             


Arg Arg  Ser Ser Asn Val Ser  Tyr Lys Tyr Ser Lys  Val Asn Lys 
    2345                 2350                 2355             


Glu Glu  Glu Thr Asp Glu Asn  Glu Thr Glu Trp Leu  Met Glu Glu 
    2360                 2365                 2370             


Ile Gln  Leu Pro Pro Pro Arg  Gln Gly Lys Glu Gly  Gln Glu Asn 
    2375                 2380                 2385             


Gly His  Ile Thr Thr Lys Ser  Val Lys Ala Leu Ser  Ser Leu His 
    2390                 2395                 2400             


Gly Asp  Asp Gln Asp Ser Glu  Asp Glu Val Leu Thr  Ile Pro Glu 
    2405                 2410                 2415             


Val Lys  Val His Ser Gly Arg  Gly Ala Gly Ala Glu  Ser Ser His 
    2420                 2425                 2430             


Pro Val  Arg Asn Ala Gln Ser  Asn Ala Leu Gln Glu  Arg Glu Asp 
    2435                 2440                 2445             


Asp Arg  Val Gly Leu Val Arg  Gly Glu Lys Ala Arg  Lys Gly Lys 
    2450                 2455                 2460             


Ser Ser  Ser Ala Gln Gln Lys  Thr Val Ser Ser Thr  Lys Leu Val 
    2465                 2470                 2475             


Ser Phe  His Asp Asp Ser Asp  Glu Asp Leu Leu His  Ile 
    2480                 2485                 2490     


<210>  5364
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFALS__Homo_sapiens__NP_001139478

<400>  5364

Met Ala Leu Arg Lys Ala Gly Asp Leu Glu Pro Gln Phe Thr Pro Glu 
1               5                   10                  15      


Arg Arg Phe Arg Leu Cys Trp Tyr Gln Ala His Ser Gly Arg Ala Leu 
            20                  25                  30          


Leu Gly Pro Pro Pro Gln Ala Ser Pro Pro Ala Gly Gly Leu Ala Leu 
        35                  40                  45              


Ala Leu Leu Leu Leu Ser Trp Val Ala Leu Gly Pro Arg Ser Leu Glu 
    50                  55                  60                  


Gly Ala Asp Pro Gly Thr Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro 
65                  70                  75                  80  


Ala Ala Cys Val Cys Ser Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val 
                85                  90                  95      


Phe Cys Ser Ser Arg Asn Leu Thr Arg Leu Pro Asp Gly Val Pro Gly 
            100                 105                 110         


Gly Thr Gln Ala Leu Trp Leu Asp Gly Asn Asn Leu Ser Ser Val Pro 
        115                 120                 125             


Pro Ala Ala Phe Gln Asn Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln 
    130                 135                 140                 


Gly Gly Gln Leu Gly Ser Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu 
145                 150                 155                 160 


Asn Leu Cys His Leu His Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala 
                165                 170                 175     


Leu Gly Thr Phe Ala His Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser 
            180                 185                 190         


Asn Asn Arg Leu Ser Arg Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly 
        195                 200                 205             


Ser Leu Trp Asp Leu Asn Leu Gly Trp Asn Ser Leu Ala Val Leu Pro 
    210                 215                 220                 


Asp Ala Ala Phe Arg Gly Leu Gly Ser Leu Arg Glu Leu Val Leu Ala 
225                 230                 235                 240 


Gly Asn Arg Leu Ala Tyr Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala 
                245                 250                 255     


Glu Leu Arg Glu Leu Asp Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys 
            260                 265                 270         


Ala Asn Val Phe Val Gln Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp 
        275                 280                 285             


Arg Asn Leu Ile Ala Ala Val Ala Pro Gly Ala Phe Leu Gly Leu Lys 
    290                 295                 300                 


Ala Leu Arg Trp Leu Asp Leu Ser His Asn Arg Val Ala Gly Leu Leu 
305                 310                 315                 320 


Glu Asp Thr Phe Pro Gly Leu Leu Gly Leu Arg Val Leu Arg Leu Ser 
                325                 330                 335     


His Asn Ala Ile Ala Ser Leu Arg Pro Arg Thr Phe Lys Asp Leu His 
            340                 345                 350         


Phe Leu Glu Glu Leu Gln Leu Gly His Asn Arg Ile Arg Gln Leu Ala 
        355                 360                 365             


Glu Arg Ser Phe Glu Gly Leu Gly Gln Leu Glu Val Leu Thr Leu Asp 
    370                 375                 380                 


His Asn Gln Leu Gln Glu Val Lys Ala Gly Ala Phe Leu Gly Leu Thr 
385                 390                 395                 400 


Asn Val Ala Val Met Asn Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro 
                405                 410                 415     


Glu Gln Val Phe Arg Gly Leu Gly Lys Leu His Ser Leu His Leu Glu 
            420                 425                 430         


Gly Ser Cys Leu Gly Arg Ile Arg Pro His Thr Phe Thr Gly Leu Ser 
        435                 440                 445             


Gly Leu Arg Arg Leu Phe Leu Lys Asp Asn Gly Leu Val Gly Ile Glu 
    450                 455                 460                 


Glu Gln Ser Leu Trp Gly Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr 
465                 470                 475                 480 


Ser Asn Gln Leu Thr His Leu Pro His Arg Leu Phe Gln Gly Leu Gly 
                485                 490                 495     


Lys Leu Glu Tyr Leu Leu Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro 
            500                 505                 510         


Ala Asp Ala Leu Gly Pro Leu Gln Arg Ala Phe Trp Leu Asp Val Ser 
        515                 520                 525             


His Asn Arg Leu Glu Ala Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly 
    530                 535                 540                 


Arg Leu Arg Tyr Leu Ser Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr 
545                 550                 555                 560 


Pro Gln Pro Pro Gly Leu Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp 
                565                 570                 575     


Asp Cys Gly Cys Pro Leu Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn 
            580                 585                 590         


Pro Ser Ala Val Pro Arg Phe Val Gln Ala Ile Cys Glu Gly Asp Asp 
        595                 600                 605             


Cys Gln Pro Pro Ala Tyr Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro 
    610                 615                 620                 


Pro Glu Val Val Gly Leu Asp Leu Arg Asp Leu Ser Glu Ala His Phe 
625                 630                 635                 640 


Ala Pro Cys 
            


<210>  5365
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBP1__Homo_sapiens__NP_000587

<400>  5365

Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 
            20                  25                  30          


Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 
        35                  40                  45              


Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 
65                  70                  75                  80  


Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 
                85                  90                  95      


Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 
            100                 105                 110         


Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 
        115                 120                 125             


Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 
    130                 135                 140                 


Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 
145                 150                 155                 160 


Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 
                165                 170                 175     


Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 
            180                 185                 190         


Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 
        195                 200                 205             


Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 
    210                 215                 220                 


Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 
225                 230                 235                 240 


Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 
                245                 250                 255     


Val Gln Asn 
            


<210>  5366
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBP2__Homo_sapiens__NP_000588

<400>  5366

Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys 
        35                  40                  45              


Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro 
    50                  55                  60                  


Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu 
65                  70                  75                  80  


Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu 
                85                  90                  95      


Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu 
            100                 105                 110         


Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val 
        115                 120                 125             


Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala 
    130                 135                 140                 


Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly 
145                 150                 155                 160 


Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly 
                165                 170                 175     


Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala 
            180                 185                 190         


Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly 
        195                 200                 205             


Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro 
    210                 215                 220                 


Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg 
225                 230                 235                 240 


Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu 
                245                 250                 255     


Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu 
            260                 265                 270         


Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys 
        275                 280                 285             


Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg 
    290                 295                 300                 


Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg 
305                 310                 315                 320 


Gly Val His Thr Gln Arg Met Gln 
                325             


<210>  5367
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBP3__Homo_sapiens__NP_000589

<400>  5367

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210>  5368
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBP4__Homo_sapiens__NP_001543

<400>  5368

Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly Asp Glu Ala Ile His Cys Pro Pro Cys Ser Glu 
            20                  25                  30          


Glu Lys Leu Ala Arg Cys Arg Pro Pro Val Gly Cys Glu Glu Leu Val 
        35                  40                  45              


Arg Glu Pro Gly Cys Gly Cys Cys Ala Thr Cys Ala Leu Gly Leu Gly 
    50                  55                  60                  


Met Pro Cys Gly Val Tyr Thr Pro Arg Cys Gly Ser Gly Leu Arg Cys 
65                  70                  75                  80  


Tyr Pro Pro Arg Gly Val Glu Lys Pro Leu His Thr Leu Met His Gly 
                85                  90                  95      


Gln Gly Val Cys Met Glu Leu Ala Glu Ile Glu Ala Ile Gln Glu Ser 
            100                 105                 110         


Leu Gln Pro Ser Asp Lys Asp Glu Gly Asp His Pro Asn Asn Ser Phe 
        115                 120                 125             


Ser Pro Cys Ser Ala His Asp Arg Arg Cys Leu Gln Lys His Phe Ala 
    130                 135                 140                 


Lys Ile Arg Asp Arg Ser Thr Ser Gly Gly Lys Met Lys Val Asn Gly 
145                 150                 155                 160 


Ala Pro Arg Glu Asp Ala Arg Pro Val Pro Gln Gly Ser Cys Gln Ser 
                165                 170                 175     


Glu Leu His Arg Ala Leu Glu Arg Leu Ala Ala Ser Gln Ser Arg Thr 
            180                 185                 190         


His Glu Asp Leu Tyr Ile Ile Pro Ile Pro Asn Cys Asp Arg Asn Gly 
        195                 200                 205             


Asn Phe His Pro Lys Gln Cys His Pro Ala Leu Asp Gly Gln Arg Gly 
    210                 215                 220                 


Lys Cys Trp Cys Val Asp Arg Lys Thr Gly Val Lys Leu Pro Gly Gly 
225                 230                 235                 240 


Leu Glu Pro Lys Gly Glu Leu Asp Cys His Gln Leu Ala Asp Ser Phe 
                245                 250                 255     


Arg Glu 
        


<210>  5369
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBP5__Homo_sapiens__NP_000590

<400>  5369

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210>  5370
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBP6__Homo_sapiens__NP_002169

<400>  5370

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  5371
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBP7__Homo_sapiens__NP_001240764

<400>  5371

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Thr Gln 
        275                 


<210>  5372
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFBPL1__Homo_sapiens__NP_001007564

<400>  5372

Met Pro Arg Leu Ser Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Pro Pro Leu Ser Pro Ser Leu Gly Ile Arg Asp Val Gly 
            20                  25                  30          


Gly Arg Arg Pro Lys Cys Gly Pro Cys Arg Pro Glu Gly Cys Pro Ala 
        35                  40                  45              


Pro Ala Pro Cys Pro Ala Pro Gly Ile Ser Ala Leu Asp Glu Cys Gly 
    50                  55                  60                  


Cys Cys Ala Arg Cys Leu Gly Ala Glu Gly Ala Ser Cys Gly Gly Arg 
65                  70                  75                  80  


Ala Gly Gly Arg Cys Gly Pro Gly Leu Val Cys Ala Ser Gln Ala Ala 
                85                  90                  95      


Gly Ala Ala Pro Glu Gly Thr Gly Leu Cys Val Cys Ala Gln Arg Gly 
            100                 105                 110         


Thr Val Cys Gly Ser Asp Gly Arg Ser Tyr Pro Ser Val Cys Ala Leu 
        115                 120                 125             


Arg Leu Arg Ala Arg His Thr Pro Arg Ala His Pro Gly His Leu His 
    130                 135                 140                 


Lys Ala Arg Asp Gly Pro Cys Glu Phe Ala Pro Val Val Val Val Pro 
145                 150                 155                 160 


Pro Arg Ser Val His Asn Val Thr Gly Ala Gln Val Gly Leu Ser Cys 
                165                 170                 175     


Glu Val Arg Ala Val Pro Thr Pro Val Ile Thr Trp Arg Lys Val Thr 
            180                 185                 190         


Lys Ser Pro Glu Gly Thr Gln Ala Leu Glu Glu Leu Pro Gly Asp His 
        195                 200                 205             


Val Asn Ile Ala Val Gln Val Arg Gly Gly Pro Ser Asp His Glu Ala 
    210                 215                 220                 


Thr Ala Trp Ile Leu Ile Asn Pro Leu Arg Lys Glu Asp Glu Gly Val 
225                 230                 235                 240 


Tyr Gln Cys His Ala Ala Asn Met Val Gly Glu Ala Glu Ser His Ser 
                245                 250                 255     


Thr Val Thr Val Leu Asp Leu Ser Lys Tyr Arg Ser Phe His Phe Pro 
            260                 265                 270         


Ala Pro Asp Asp Arg Met 
        275             


<210>  5373
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFL1__Homo_sapiens__NP_940943

<400>  5373

Met Ala Pro Arg Gly Cys Ile Val Ala Val Phe Ala Ile Phe Cys Ile 
1               5                   10                  15      


Ser Arg Leu Leu Cys Ser His Gly Ala Pro Val Ala Pro Met Thr Pro 
            20                  25                  30          


Tyr Leu Met Leu Cys Gln Pro His Lys Arg Cys Gly Asp Lys Phe Tyr 
        35                  40                  45              


Asp Pro Leu Gln His Cys Cys Tyr Asp Asp Ala Val Val Pro Leu Ala 
    50                  55                  60                  


Arg Thr Gln Thr Cys Gly Asn Cys Thr Phe Arg Val Cys Phe Glu Gln 
65                  70                  75                  80  


Cys Cys Pro Trp Thr Phe Met Val Lys Leu Ile Asn Gln Asn Cys Asp 
                85                  90                  95      


Ser Ala Arg Thr Ser Asp Asp Arg Leu Cys Arg Ser Val Ser 
            100                 105                 110 


<210>  5374
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGFLR1__Homo_sapiens__NP_078936

<400>  5374

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala Ser Ser 
    130                 135                 140                 


Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala Trp Pro Asn 
145                 150                 155                 160 


Phe Leu Pro Leu Val Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile 
                165                 170                 175     


Ala Ile Leu Leu Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu 
            180                 185                 190         


Lys Ala Asp Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn 
        195                 200                 205             


Thr His Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu 
    210                 215                 220                 


Thr Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu 
                245                 250                 255     


Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly 
            260                 265                 270         


Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg 
        275                 280                 285             


Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro 
    290                 295                 300                 


Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu 
305                 310                 315                 320 


Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly 
                325                 330                 335     


Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val 
            340                 345                 350         


Cys Trp Ala 
        355 


<210>  5375
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHMBP2__Homo_sapiens__NP_002171

<400>  5375

Met Ala Ser Ala Ala Val Glu Ser Phe Val Thr Lys Gln Leu Asp Leu 
1               5                   10                  15      


Leu Glu Leu Glu Arg Asp Ala Glu Val Glu Glu Arg Arg Ser Trp Gln 
            20                  25                  30          


Glu Asn Ile Ser Leu Lys Glu Leu Gln Ser Arg Gly Val Cys Leu Leu 
        35                  40                  45              


Lys Leu Gln Val Ser Ser Gln Arg Thr Gly Leu Tyr Gly Arg Leu Leu 
    50                  55                  60                  


Val Thr Phe Glu Pro Arg Arg Tyr Gly Ser Ala Ala Ala Leu Pro Ser 
65                  70                  75                  80  


Asn Ser Phe Thr Ser Gly Asp Ile Val Gly Leu Tyr Asp Ala Ala Asn 
                85                  90                  95      


Glu Gly Ser Gln Leu Ala Thr Gly Ile Leu Thr Arg Val Thr Gln Lys 
            100                 105                 110         


Ser Val Thr Val Ala Phe Asp Glu Ser His Asp Phe Gln Leu Ser Leu 
        115                 120                 125             


Asp Arg Glu Asn Ser Tyr Arg Leu Leu Lys Leu Ala Asn Asp Val Thr 
    130                 135                 140                 


Tyr Arg Arg Leu Lys Lys Ala Leu Ile Ala Leu Lys Lys Tyr His Ser 
145                 150                 155                 160 


Gly Pro Ala Ser Ser Leu Ile Glu Val Leu Phe Gly Arg Ser Ala Pro 
                165                 170                 175     


Ser Pro Ala Ser Glu Ile His Pro Leu Thr Phe Phe Asn Thr Cys Leu 
            180                 185                 190         


Asp Thr Ser Gln Lys Glu Ala Val Leu Phe Ala Leu Ser Gln Lys Glu 
        195                 200                 205             


Leu Ala Ile Ile His Gly Pro Pro Gly Thr Gly Lys Thr Thr Thr Val 
    210                 215                 220                 


Val Glu Ile Ile Leu Gln Ala Val Lys Gln Gly Leu Lys Val Leu Cys 
225                 230                 235                 240 


Cys Ala Pro Ser Asn Ile Ala Val Asp Asn Leu Val Glu Arg Leu Ala 
                245                 250                 255     


Leu Cys Lys Gln Arg Ile Leu Arg Leu Gly His Pro Ala Arg Leu Leu 
            260                 265                 270         


Glu Ser Ile Gln Gln His Ser Leu Asp Ala Val Leu Ala Arg Ser Asp 
        275                 280                 285             


Ser Ala Gln Ile Val Ala Asp Ile Arg Lys Asp Ile Asp Gln Val Phe 
    290                 295                 300                 


Val Lys Asn Lys Lys Thr Gln Asp Lys Arg Glu Lys Ser Asn Phe Arg 
305                 310                 315                 320 


Asn Glu Ile Lys Leu Leu Arg Lys Glu Leu Lys Glu Arg Glu Glu Ala 
                325                 330                 335     


Ala Met Leu Glu Ser Leu Thr Ser Ala Asn Val Val Leu Ala Thr Asn 
            340                 345                 350         


Thr Gly Ala Ser Ala Asp Gly Pro Leu Lys Leu Leu Pro Glu Ser Tyr 
        355                 360                 365             


Phe Asp Val Val Val Ile Asp Glu Cys Ala Gln Ala Leu Glu Ala Ser 
    370                 375                 380                 


Cys Trp Ile Pro Leu Leu Lys Ala Arg Lys Cys Ile Leu Ala Gly Asp 
385                 390                 395                 400 


His Lys Gln Leu Pro Pro Thr Thr Val Ser His Lys Ala Ala Leu Ala 
                405                 410                 415     


Gly Leu Ser Leu Ser Leu Met Glu Arg Leu Ala Glu Glu Tyr Gly Ala 
            420                 425                 430         


Arg Val Val Arg Thr Leu Thr Val Gln Tyr Arg Met His Gln Ala Ile 
        435                 440                 445             


Met Arg Trp Ala Ser Asp Thr Met Tyr Leu Gly Gln Leu Thr Ala His 
    450                 455                 460                 


Ser Ser Val Ala Arg His Leu Leu Arg Asp Leu Pro Gly Val Ala Ala 
465                 470                 475                 480 


Thr Glu Glu Thr Gly Val Pro Leu Leu Leu Val Asp Thr Ala Gly Cys 
                485                 490                 495     


Gly Leu Phe Glu Leu Glu Glu Glu Asp Glu Gln Ser Lys Gly Asn Pro 
            500                 505                 510         


Gly Glu Val Arg Leu Val Ser Leu His Ile Gln Ala Leu Val Asp Ala 
        515                 520                 525             


Gly Val Pro Ala Arg Asp Ile Ala Val Val Ser Pro Tyr Asn Leu Gln 
    530                 535                 540                 


Val Asp Leu Leu Arg Gln Ser Leu Val His Arg His Pro Glu Leu Glu 
545                 550                 555                 560 


Ile Lys Ser Val Asp Gly Phe Gln Gly Arg Glu Lys Glu Ala Val Ile 
                565                 570                 575     


Leu Ser Phe Val Arg Ser Asn Arg Lys Gly Glu Val Gly Phe Leu Ala 
            580                 585                 590         


Glu Asp Arg Arg Ile Asn Val Ala Val Thr Arg Ala Arg Arg His Val 
        595                 600                 605             


Ala Val Ile Cys Asp Ser Arg Thr Val Asn Asn His Ala Phe Leu Lys 
    610                 615                 620                 


Thr Leu Val Glu Tyr Phe Thr Gln His Gly Glu Val Arg Thr Ala Phe 
625                 630                 635                 640 


Glu Tyr Leu Asp Asp Ile Val Pro Glu Asn Tyr Ser His Glu Asn Ser 
                645                 650                 655     


Gln Gly Ser Ser His Ala Ala Thr Lys Pro Gln Gly Pro Ala Thr Ser 
            660                 665                 670         


Thr Arg Thr Gly Ser Gln Arg Gln Glu Gly Gly Gln Glu Ala Ala Ala 
        675                 680                 685             


Pro Ala Arg Gln Gly Arg Lys Lys Pro Ala Gly Lys Ser Leu Ala Ser 
    690                 695                 700                 


Glu Ala Pro Ser Gln Pro Ser Leu Asn Gly Gly Ser Pro Glu Gly Val 
705                 710                 715                 720 


Glu Ser Gln Asp Gly Val Asp His Phe Arg Ala Met Ile Val Glu Phe 
                725                 730                 735     


Met Ala Ser Lys Lys Met Gln Leu Glu Phe Pro Pro Ser Leu Asn Ser 
            740                 745                 750         


His Asp Arg Leu Arg Val His Gln Ile Ala Glu Glu His Gly Leu Arg 
        755                 760                 765             


His Asp Ser Ser Gly Glu Gly Lys Arg Arg Phe Ile Thr Val Ser Lys 
    770                 775                 780                 


Arg Ala Pro Arg Pro Arg Ala Ala Leu Gly Pro Pro Ala Gly Thr Gly 
785                 790                 795                 800 


Gly Pro Ala Pro Leu Gln Pro Val Pro Pro Thr Pro Ala Gln Thr Glu 
                805                 810                 815     


Gln Pro Pro Arg Glu Gln Arg Gly Pro Asp Gln Pro Asp Leu Arg Thr 
            820                 825                 830         


Leu His Leu Glu Arg Leu Gln Arg Val Arg Ser Ala Gln Gly Gln Pro 
        835                 840                 845             


Ala Ser Lys Glu Gln Gln Ala Ser Gly Gln Gln Lys Leu Pro Glu Lys 
    850                 855                 860                 


Lys Lys Lys Lys Ala Lys Gly His Pro Ala Thr Asp Leu Pro Thr Glu 
865                 870                 875                 880 


Glu Asp Phe Glu Ala Leu Val Ser Ala Ala Val Lys Ala Asp Asn Thr 
                885                 890                 895     


Cys Gly Phe Ala Lys Cys Thr Ala Gly Val Thr Thr Leu Gly Gln Phe 
            900                 905                 910         


Cys Gln Leu Cys Ser Arg Arg Tyr Cys Leu Ser His His Leu Pro Glu 
        915                 920                 925             


Ile His Gly Cys Gly Glu Arg Ala Arg Ala His Ala Arg Gln Arg Ile 
    930                 935                 940                 


Ser Arg Glu Gly Val Leu Tyr Ala Gly Ser Gly Thr Lys Asn Gly Ser 
945                 950                 955                 960 


Leu Asp Pro Ala Lys Arg Ala Gln Leu Gln Arg Arg Leu Asp Lys Lys 
                965                 970                 975     


Leu Ser Glu Leu Ser Asn Gln Arg Thr Ser Arg Arg Lys Glu Arg Gly 
            980                 985                 990         


Thr 
    


<210>  5376
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGJ__Homo_sapiens__NP_653247

<400>  5376

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  5377
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGLL1__Homo_sapiens__NP_064455

<400>  5377

Met Arg Pro Gly Thr Gly Gln Gly Gly Leu Glu Ala Pro Gly Glu Pro 
1               5                   10                  15      


Gly Pro Asn Leu Arg Gln Arg Trp Pro Leu Leu Leu Leu Gly Leu Ala 
            20                  25                  30          


Val Val Thr His Gly Leu Leu Arg Pro Thr Ala Ala Ser Gln Ser Arg 
        35                  40                  45              


Ala Leu Gly Pro Gly Ala Pro Gly Gly Ser Ser Arg Ser Ser Leu Arg 
    50                  55                  60                  


Ser Arg Trp Gly Arg Phe Leu Leu Gln Arg Gly Ser Trp Thr Gly Pro 
65                  70                  75                  80  


Arg Cys Trp Pro Arg Gly Phe Gln Ser Lys His Asn Ser Val Thr His 
                85                  90                  95      


Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Ser Gln Pro Lys Ala 
            100                 105                 110         


Thr Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Met Asn Asp Phe Tyr Pro Gly Ile 
    130                 135                 140                 


Leu Thr Val Thr Trp Lys Ala Asp Gly Thr Pro Ile Thr Gln Gly Val 
145                 150                 155                 160 


Glu Met Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Arg Ser Arg Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Met His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Ala Glu Cys Ser 
    210             


<210>  5378
<211>  2623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGSF10__Homo_sapiens__NP_849144

<400>  5378

Met Lys Val Lys Gly Arg Gly Ile Thr Cys Leu Leu Val Ser Phe Ala 
1               5                   10                  15      


Val Ile Cys Leu Val Ala Thr Pro Gly Gly Lys Ala Cys Pro Arg Arg 
            20                  25                  30          


Cys Ala Cys Tyr Met Pro Thr Glu Val His Cys Thr Phe Arg Tyr Leu 
        35                  40                  45              


Thr Ser Ile Pro Asp Ser Ile Pro Pro Asn Val Glu Arg Ile Asn Leu 
    50                  55                  60                  


Gly Tyr Asn Ser Leu Val Arg Leu Met Glu Thr Asp Phe Ser Gly Leu 
65                  70                  75                  80  


Thr Lys Leu Glu Leu Leu Met Leu His Ser Asn Gly Ile His Thr Ile 
                85                  90                  95      


Pro Asp Lys Thr Phe Ser Asp Leu Gln Ala Leu Gln Val Leu Lys Met 
            100                 105                 110         


Ser Tyr Asn Lys Val Arg Lys Leu Gln Lys Asp Thr Phe Tyr Gly Leu 
        115                 120                 125             


Arg Ser Leu Thr Arg Leu His Met Asp His Asn Asn Ile Glu Phe Ile 
    130                 135                 140                 


Asn Pro Glu Val Phe Tyr Gly Leu Asn Phe Leu Arg Leu Val His Leu 
145                 150                 155                 160 


Glu Gly Asn Gln Leu Thr Lys Leu His Pro Asp Thr Phe Val Ser Leu 
                165                 170                 175     


Ser Tyr Leu Gln Ile Phe Lys Ile Ser Phe Ile Lys Phe Leu Tyr Leu 
            180                 185                 190         


Ser Asp Asn Phe Leu Thr Ser Leu Pro Gln Glu Met Val Ser Tyr Met 
        195                 200                 205             


Pro Asp Leu Asp Ser Leu Tyr Leu His Gly Asn Pro Trp Thr Cys Asp 
    210                 215                 220                 


Cys His Leu Lys Trp Leu Ser Asp Trp Ile Gln Glu Lys Pro Asp Val 
225                 230                 235                 240 


Ile Lys Cys Lys Lys Asp Arg Ser Pro Ser Ser Ala Gln Gln Cys Pro 
                245                 250                 255     


Leu Cys Met Asn Pro Arg Thr Ser Lys Gly Lys Pro Leu Ala Met Val 
            260                 265                 270         


Ser Ala Ala Ala Phe Gln Cys Ala Lys Pro Thr Ile Asp Ser Ser Leu 
        275                 280                 285             


Lys Ser Lys Ser Leu Thr Ile Leu Glu Asp Ser Ser Ser Ala Phe Ile 
    290                 295                 300                 


Ser Pro Gln Gly Phe Met Ala Pro Phe Gly Ser Leu Thr Leu Asn Met 
305                 310                 315                 320 


Thr Asp Gln Ser Gly Asn Glu Ala Asn Met Val Cys Ser Ile Gln Lys 
                325                 330                 335     


Pro Ser Arg Thr Ser Pro Ile Ala Phe Thr Glu Glu Asn Asp Tyr Ile 
            340                 345                 350         


Val Leu Asn Thr Ser Phe Ser Thr Phe Leu Val Cys Asn Ile Asp Tyr 
        355                 360                 365             


Gly His Ile Gln Pro Val Trp Gln Ile Leu Ala Leu Tyr Ser Asp Ser 
    370                 375                 380                 


Pro Leu Ile Leu Glu Arg Ser His Leu Leu Ser Glu Thr Pro Gln Leu 
385                 390                 395                 400 


Tyr Tyr Lys Tyr Lys Gln Val Ala Pro Lys Pro Glu Asp Ile Phe Thr 
                405                 410                 415     


Asn Ile Glu Ala Asp Leu Arg Ala Asp Pro Ser Trp Leu Met Gln Asp 
            420                 425                 430         


Gln Ile Ser Leu Gln Leu Asn Arg Thr Ala Thr Thr Phe Ser Thr Leu 
        435                 440                 445             


Gln Ile Gln Tyr Ser Ser Asp Ala Gln Ile Thr Leu Pro Arg Ala Glu 
    450                 455                 460                 


Met Arg Pro Val Lys His Lys Trp Thr Met Ile Ser Arg Asp Asn Asn 
465                 470                 475                 480 


Thr Lys Leu Glu His Thr Val Leu Val Gly Gly Thr Val Gly Leu Asn 
                485                 490                 495     


Cys Pro Gly Gln Gly Asp Pro Thr Pro His Val Asp Trp Leu Leu Ala 
            500                 505                 510         


Asp Gly Ser Lys Val Arg Ala Pro Tyr Val Ser Glu Asp Gly Arg Ile 
        515                 520                 525             


Leu Ile Asp Lys Ser Gly Lys Leu Glu Leu Gln Met Ala Asp Ser Phe 
    530                 535                 540                 


Asp Thr Gly Val Tyr His Cys Ile Ser Ser Asn Tyr Asp Asp Ala Asp 
545                 550                 555                 560 


Ile Leu Thr Tyr Arg Ile Thr Val Val Glu Pro Leu Val Glu Ala Tyr 
                565                 570                 575     


Gln Glu Asn Gly Ile His His Thr Val Phe Ile Gly Glu Thr Leu Asp 
            580                 585                 590         


Leu Pro Cys His Ser Thr Gly Ile Pro Asp Ala Ser Ile Ser Trp Val 
        595                 600                 605             


Ile Pro Gly Asn Asn Val Leu Tyr Gln Ser Ser Arg Asp Lys Lys Val 
    610                 615                 620                 


Leu Asn Asn Gly Thr Leu Arg Ile Leu Gln Val Thr Pro Lys Asp Gln 
625                 630                 635                 640 


Gly Tyr Tyr Arg Cys Val Ala Ala Asn Pro Ser Gly Val Asp Phe Leu 
                645                 650                 655     


Ile Phe Gln Val Ser Val Lys Met Lys Gly Gln Arg Pro Leu Glu His 
            660                 665                 670         


Asp Gly Glu Thr Glu Gly Ser Gly Leu Asp Glu Ser Asn Pro Ile Ala 
        675                 680                 685             


His Leu Lys Glu Pro Pro Gly Ala Gln Leu Arg Thr Ser Ala Leu Met 
    690                 695                 700                 


Glu Ala Glu Val Gly Lys His Thr Ser Ser Thr Ser Lys Arg His Asn 
705                 710                 715                 720 


Tyr Arg Glu Leu Thr Leu Gln Arg Arg Gly Asp Ser Thr His Arg Arg 
                725                 730                 735     


Phe Arg Glu Asn Arg Arg His Phe Pro Pro Ser Ala Arg Arg Ile Asp 
            740                 745                 750         


Pro Gln His Trp Ala Ala Leu Leu Glu Lys Ala Lys Lys Asn Ala Met 
        755                 760                 765             


Pro Asp Lys Arg Glu Asn Thr Thr Val Ser Pro Pro Pro Val Val Thr 
    770                 775                 780                 


Gln Leu Pro Asn Ile Pro Gly Glu Glu Asp Asp Ser Ser Gly Met Leu 
785                 790                 795                 800 


Ala Leu His Glu Glu Phe Met Val Pro Ala Thr Lys Ala Leu Asn Leu 
                805                 810                 815     


Pro Ala Arg Thr Val Thr Ala Asp Ser Arg Thr Ile Ser Asp Ser Pro 
            820                 825                 830         


Met Thr Asn Ile Asn Tyr Gly Thr Glu Phe Ser Pro Val Val Asn Ser 
        835                 840                 845             


Gln Ile Leu Pro Pro Glu Glu Pro Thr Asp Phe Lys Leu Ser Thr Ala 
    850                 855                 860                 


Ile Lys Thr Thr Ala Met Ser Lys Asn Ile Asn Pro Thr Met Ser Ser 
865                 870                 875                 880 


Gln Ile Gln Gly Thr Thr Asn Gln His Ser Ser Thr Val Phe Pro Leu 
                885                 890                 895     


Leu Leu Gly Ala Thr Glu Phe Gln Asp Ser Asp Gln Met Gly Arg Gly 
            900                 905                 910         


Arg Glu His Phe Gln Ser Arg Pro Pro Ile Thr Val Arg Thr Met Ile 
        915                 920                 925             


Lys Asp Val Asn Val Lys Met Leu Ser Ser Thr Thr Asn Lys Leu Leu 
    930                 935                 940                 


Leu Glu Ser Val Asn Thr Thr Asn Ser His Gln Thr Ser Val Arg Glu 
945                 950                 955                 960 


Val Ser Glu Pro Arg His Asn His Phe Tyr Ser His Thr Thr Gln Ile 
                965                 970                 975     


Leu Ser Thr Ser Thr Phe Pro Ser Asp Pro His Thr Ala Ala His Ser 
            980                 985                 990         


Gln Phe Pro Ile Pro Arg Asn Ser  Thr Val Asn Ile Pro  Leu Phe Arg 
        995                 1000                 1005             


Arg Phe  Gly Arg Gln Arg Lys  Ile Gly Gly Arg Gly  Arg Ile Ile 
    1010                 1015                 1020             


Ser Pro  Tyr Arg Thr Pro Val  Leu Arg Arg His Arg  Tyr Ser Ile 
    1025                 1030                 1035             


Phe Arg  Ser Thr Thr Arg Gly  Ser Ser Glu Lys Ser  Thr Thr Ala 
    1040                 1045                 1050             


Phe Ser  Ala Thr Val Leu Asn  Val Thr Cys Leu Ser  Cys Leu Pro 
    1055                 1060                 1065             


Arg Glu  Arg Leu Thr Thr Ala  Thr Ala Ala Leu Ser  Phe Pro Ser 
    1070                 1075                 1080             


Ala Ala  Pro Ile Thr Phe Pro  Lys Ala Asp Ile Ala  Arg Val Pro 
    1085                 1090                 1095             


Ser Glu  Glu Ser Thr Thr Leu  Val Gln Asn Pro Leu  Leu Leu Leu 
    1100                 1105                 1110             


Glu Asn  Lys Pro Ser Val Glu  Lys Thr Thr Pro Thr  Ile Lys Tyr 
    1115                 1120                 1125             


Phe Arg  Thr Glu Ile Ser Gln  Val Thr Pro Thr Gly  Ala Val Met 
    1130                 1135                 1140             


Thr Tyr  Ala Pro Thr Ser Ile  Pro Met Glu Lys Thr  His Lys Val 
    1145                 1150                 1155             


Asn Ala  Ser Tyr Pro Arg Val  Ser Ser Thr Asn Glu  Ala Lys Arg 
    1160                 1165                 1170             


Asp Ser  Val Ile Thr Ser Ser  Leu Ser Gly Ala Ile  Thr Lys Pro 
    1175                 1180                 1185             


Pro Met  Thr Ile Ile Ala Ile  Thr Arg Phe Ser Arg  Arg Lys Ile 
    1190                 1195                 1200             


Pro Trp  Gln Gln Asn Phe Val  Asn Asn His Asn Pro  Lys Gly Arg 
    1205                 1210                 1215             


Leu Arg  Asn Gln His Lys Val  Ser Leu Gln Lys Ser  Thr Ala Val 
    1220                 1225                 1230             


Met Leu  Pro Lys Thr Ser Pro  Ala Leu Pro Arg Asp  Lys Val Ser 
    1235                 1240                 1245             


Pro Phe  His Phe Thr Thr Leu  Ser Thr Ser Val Met  Gln Ile Pro 
    1250                 1255                 1260             


Ser Asn  Thr Leu Thr Thr Ala  His His Thr Thr Thr  Lys Thr His 
    1265                 1270                 1275             


Asn Pro  Gly Ser Leu Pro Thr  Lys Lys Glu Leu Pro  Phe Pro Pro 
    1280                 1285                 1290             


Leu Asn  Pro Met Leu Pro Ser  Ile Ile Ser Lys Asp  Ser Ser Thr 
    1295                 1300                 1305             


Lys Ser  Ile Ile Ser Thr Gln  Thr Ala Ile Pro Ala  Thr Thr Pro 
    1310                 1315                 1320             


Thr Phe  Pro Ala Ser Val Ile  Thr Tyr Glu Thr Gln  Thr Glu Arg 
    1325                 1330                 1335             


Ser Arg  Ala Gln Thr Ile Gln  Arg Glu Gln Glu Pro  Gln Lys Lys 
    1340                 1345                 1350             


Asn Arg  Thr Asp Pro Asn Ile  Ser Pro Asp Gln Ser  Ser Gly Phe 
    1355                 1360                 1365             


Thr Thr  Pro Thr Ala Met Thr  Pro Pro Val Leu Thr  Thr Ala Glu 
    1370                 1375                 1380             


Thr Ser  Val Lys Pro Ser Val  Ser Ala Phe Thr His  Ser Pro Pro 
    1385                 1390                 1395             


Glu Asn  Thr Thr Gly Ile Ser  Ser Thr Ile Ser Phe  His Ser Arg 
    1400                 1405                 1410             


Thr Leu  Asn Leu Thr Asp Val  Ile Glu Glu Leu Ala  Gln Ala Ser 
    1415                 1420                 1425             


Thr Gln  Thr Leu Lys Ser Thr  Ile Ala Ser Glu Thr  Thr Leu Ser 
    1430                 1435                 1440             


Ser Lys  Ser His Gln Ser Thr  Thr Thr Arg Lys Ala  Ile Ile Arg 
    1445                 1450                 1455             


His Ser  Thr Ile Pro Pro Phe  Leu Ser Ser Ser Ala  Thr Leu Met 
    1460                 1465                 1470             


Pro Val  Pro Ile Ser Pro Pro  Phe Thr Gln Arg Ala  Val Thr Asp 
    1475                 1480                 1485             


Asn Val  Ala Thr Pro Ile Ser  Gly Leu Met Thr Asn  Thr Val Val 
    1490                 1495                 1500             


Lys Leu  His Glu Ser Ser Arg  His Asn Ala Lys Pro  Gln Gln Leu 
    1505                 1510                 1515             


Val Ala  Glu Val Ala Thr Ser  Pro Lys Val His Pro  Asn Ala Lys 
    1520                 1525                 1530             


Phe Thr  Ile Gly Thr Thr His  Phe Ile Tyr Ser Asn  Leu Leu His 
    1535                 1540                 1545             


Ser Thr  Pro Met Pro Ala Leu  Thr Thr Val Lys Ser  Gln Asn Ser 
    1550                 1555                 1560             


Lys Leu  Thr Pro Ser Pro Trp  Ala Glu Asn Gln Phe  Trp His Lys 
    1565                 1570                 1575             


Pro Tyr  Ser Glu Ile Ala Glu  Lys Gly Lys Lys Pro  Glu Val Ser 
    1580                 1585                 1590             


Met Leu  Ala Thr Thr Gly Leu  Ser Glu Ala Thr Thr  Leu Val Ser 
    1595                 1600                 1605             


Asp Trp  Asp Gly Gln Lys Asn  Thr Lys Lys Ser Asp  Phe Asp Lys 
    1610                 1615                 1620             


Lys Pro  Val Gln Glu Ala Thr  Thr Ser Lys Leu Leu  Pro Phe Asp 
    1625                 1630                 1635             


Ser Leu  Ser Arg Tyr Ile Phe  Glu Lys Pro Arg Ile  Val Gly Gly 
    1640                 1645                 1650             


Lys Ala  Ala Ser Phe Thr Ile  Pro Ala Asn Ser Asp  Ala Phe Leu 
    1655                 1660                 1665             


Pro Cys  Glu Ala Val Gly Asn  Pro Leu Pro Thr Ile  His Trp Thr 
    1670                 1675                 1680             


Arg Val  Pro Ser Gly Leu Asp  Leu Ser Lys Arg Lys  Gln Asn Ser 
    1685                 1690                 1695             


Arg Val  Gln Val Leu Pro Asn  Gly Thr Leu Ser Ile  Gln Arg Val 
    1700                 1705                 1710             


Glu Ile  Gln Asp Arg Gly Gln  Tyr Leu Cys Ser Ala  Ser Asn Leu 
    1715                 1720                 1725             


Phe Gly  Thr Asp His Leu His  Val Thr Leu Ser Val  Val Ser Tyr 
    1730                 1735                 1740             


Pro Pro  Arg Ile Leu Glu Arg  Arg Thr Lys Glu Ile  Thr Val His 
    1745                 1750                 1755             


Ser Gly  Ser Thr Val Glu Leu  Lys Cys Arg Ala Glu  Gly Arg Pro 
    1760                 1765                 1770             


Ser Pro  Thr Val Thr Trp Ile  Leu Ala Asn Gln Thr  Val Val Ser 
    1775                 1780                 1785             


Glu Ser  Ser Gln Gly Ser Arg  Gln Ala Val Val Thr  Val Asp Gly 
    1790                 1795                 1800             


Thr Leu  Val Leu His Asn Leu  Ser Ile Tyr Asp Arg  Gly Phe Tyr 
    1805                 1810                 1815             


Lys Cys  Val Ala Ser Asn Pro  Gly Gly Gln Asp Ser  Leu Leu Val 
    1820                 1825                 1830             


Lys Ile  Gln Val Ile Ala Ala  Pro Pro Val Ile Leu  Glu Gln Arg 
    1835                 1840                 1845             


Arg Gln  Val Ile Val Gly Thr  Trp Gly Glu Ser Leu  Lys Leu Pro 
    1850                 1855                 1860             


Cys Thr  Ala Lys Gly Thr Pro  Gln Pro Ser Val Tyr  Trp Val Leu 
    1865                 1870                 1875             


Ser Asp  Gly Thr Glu Val Lys  Pro Leu Gln Phe Thr  Asn Ser Lys 
    1880                 1885                 1890             


Leu Phe  Leu Phe Ser Asn Gly  Thr Leu Tyr Ile Arg  Asn Leu Ala 
    1895                 1900                 1905             


Ser Ser  Asp Arg Gly Thr Tyr  Glu Cys Ile Ala Thr  Ser Ser Thr 
    1910                 1915                 1920             


Gly Ser  Glu Arg Arg Val Val  Met Leu Thr Met Glu  Glu Arg Val 
    1925                 1930                 1935             


Thr Ser  Pro Arg Ile Glu Ala  Ala Ser Gln Lys Arg  Thr Glu Val 
    1940                 1945                 1950             


Asn Phe  Gly Asp Lys Leu Leu  Leu Asn Cys Ser Ala  Thr Gly Glu 
    1955                 1960                 1965             


Pro Lys  Pro Gln Ile Met Trp  Arg Leu Pro Ser Lys  Ala Val Val 
    1970                 1975                 1980             


Asp Gln  Gln His Arg Val Gly  Ser Trp Ile His Val  Tyr Pro Asn 
    1985                 1990                 1995             


Gly Ser  Leu Phe Ile Gly Ser  Val Thr Glu Lys Asp  Ser Gly Val 
    2000                 2005                 2010             


Tyr Leu  Cys Val Ala Arg Asn  Lys Met Gly Asp Asp  Leu Ile Leu 
    2015                 2020                 2025             


Met His  Val Ser Leu Arg Leu  Lys Pro Ala Lys Ile  Asp His Lys 
    2030                 2035                 2040             


Gln Tyr  Phe Arg Lys Gln Val  Leu His Gly Lys Asp  Phe Gln Val 
    2045                 2050                 2055             


Asp Cys  Lys Ala Ser Gly Ser  Pro Val Pro Glu Ile  Ser Trp Ser 
    2060                 2065                 2070             


Leu Pro  Asp Gly Thr Met Ile  Asn Asn Ala Met Gln  Ala Asp Asp 
    2075                 2080                 2085             


Ser Gly  His Arg Thr Arg Arg  Tyr Thr Leu Phe Asn  Asn Gly Thr 
    2090                 2095                 2100             


Leu Tyr  Phe Asn Lys Val Gly  Val Ala Glu Glu Gly  Asp Tyr Thr 
    2105                 2110                 2115             


Cys Tyr  Ala Gln Asn Thr Leu  Gly Lys Asp Glu Met  Lys Val His 
    2120                 2125                 2130             


Leu Thr  Val Ile Thr Ala Ala  Pro Arg Ile Arg Gln  Ser Asn Lys 
    2135                 2140                 2145             


Thr Asn  Lys Arg Ile Lys Ala  Gly Asp Thr Ala Val  Leu Asp Cys 
    2150                 2155                 2160             


Glu Val  Thr Gly Asp Pro Lys  Pro Lys Ile Phe Trp  Leu Leu Pro 
    2165                 2170                 2175             


Ser Asn  Asp Met Ile Ser Phe  Ser Ile Asp Arg Tyr  Thr Phe His 
    2180                 2185                 2190             


Ala Asn  Gly Ser Leu Thr Ile  Asn Lys Val Lys Leu  Leu Asp Ser 
    2195                 2200                 2205             


Gly Glu  Tyr Val Cys Val Ala  Arg Asn Pro Ser Gly  Asp Asp Thr 
    2210                 2215                 2220             


Lys Met  Tyr Lys Leu Asp Val  Val Ser Lys Pro Pro  Leu Ile Asn 
    2225                 2230                 2235             


Gly Leu  Tyr Thr Asn Arg Thr  Val Ile Lys Ala Thr  Ala Val Arg 
    2240                 2245                 2250             


His Ser  Lys Lys His Phe Asp  Cys Arg Ala Glu Gly  Thr Pro Ser 
    2255                 2260                 2265             


Pro Glu  Val Met Trp Ile Met  Pro Asp Asn Ile Phe  Leu Thr Ala 
    2270                 2275                 2280             


Pro Tyr  Tyr Gly Ser Arg Ile  Thr Val His Lys Asn  Gly Thr Leu 
    2285                 2290                 2295             


Glu Ile  Arg Asn Val Arg Leu  Ser Asp Ser Ala Asp  Phe Ile Cys 
    2300                 2305                 2310             


Val Ala  Arg Asn Glu Gly Gly  Glu Ser Val Leu Val  Val Gln Leu 
    2315                 2320                 2325             


Glu Val  Leu Glu Met Leu Arg  Arg Pro Thr Phe Arg  Asn Pro Phe 
    2330                 2335                 2340             


Asn Glu  Lys Ile Val Ala Gln  Leu Gly Lys Ser Thr  Ala Leu Asn 
    2345                 2350                 2355             


Cys Ser  Val Asp Gly Asn Pro  Pro Pro Glu Ile Ile  Trp Ile Leu 
    2360                 2365                 2370             


Pro Asn  Gly Thr Arg Phe Ser  Asn Gly Pro Gln Ser  Tyr Gln Tyr 
    2375                 2380                 2385             


Leu Ile  Ala Ser Asn Gly Ser  Phe Ile Ile Ser Lys  Thr Thr Arg 
    2390                 2395                 2400             


Glu Asp  Ala Gly Lys Tyr Arg  Cys Ala Ala Arg Asn  Lys Val Gly 
    2405                 2410                 2415             


Tyr Ile  Glu Lys Leu Val Ile  Leu Glu Ile Gly Gln  Lys Pro Val 
    2420                 2425                 2430             


Ile Leu  Thr Tyr Ala Pro Gly  Thr Val Lys Gly Ile  Ser Gly Glu 
    2435                 2440                 2445             


Ser Leu  Ser Leu His Cys Val  Ser Asp Gly Ile Pro  Lys Pro Asn 
    2450                 2455                 2460             


Ile Lys  Trp Thr Met Pro Ser  Gly Tyr Val Val Asp  Arg Pro Gln 
    2465                 2470                 2475             


Ile Asn  Gly Lys Tyr Ile Leu  His Asp Asn Gly Thr  Leu Val Ile 
    2480                 2485                 2490             


Lys Glu  Ala Thr Ala Tyr Asp  Arg Gly Asn Tyr Ile  Cys Lys Ala 
    2495                 2500                 2505             


Gln Asn  Ser Val Gly His Thr  Leu Ile Thr Val Pro  Val Met Ile 
    2510                 2515                 2520             


Val Ala  Tyr Pro Pro Arg Ile  Thr Asn Arg Pro Pro  Arg Ser Ile 
    2525                 2530                 2535             


Val Thr  Arg Thr Gly Ala Ala  Phe Gln Leu His Cys  Val Ala Leu 
    2540                 2545                 2550             


Gly Val  Pro Lys Pro Glu Ile  Thr Trp Glu Met Pro  Asp His Ser 
    2555                 2560                 2565             


Leu Leu  Ser Thr Ala Ser Lys  Glu Arg Thr His Gly  Ser Glu Gln 
    2570                 2575                 2580             


Leu His  Leu Gln Gly Thr Leu  Val Ile Gln Asn Pro  Gln Thr Ser 
    2585                 2590                 2595             


Asp Ser  Gly Ile Tyr Lys Cys  Thr Ala Lys Asn Pro  Leu Gly Ser 
    2600                 2605                 2610             


Asp Tyr  Ala Ala Thr Tyr Ile  Gln Val Ile 
    2615                 2620             


<210>  5379
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGSF11__Homo_sapiens__NP_001015887

<400>  5379

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile 
225                 230                 235                 240 


Gly Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe 
                245                 250                 255     


Cys Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn 
            260                 265                 270         


Lys Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp 
        275                 280                 285             


Leu Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser 
    290                 295                 300                 


Ser Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg 
305                 310                 315                 320 


Tyr Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser 
                325                 330                 335     


His Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala 
            340                 345                 350         


Asn Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln 
        355                 360                 365             


His Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val 
    370                 375                 380                 


Met Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His 
385                 390                 395                 400 


Thr His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala 
                405                 410                 415     


Val Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430     


<210>  5380
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGSF1__Homo_sapiens__NP_001164432

<400>  5380

Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe 
1               5                   10                  15      


Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile 
            20                  25                  30          


Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln 
        35                  40                  45              


Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile 
    50                  55                  60                  


Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile 
65                  70                  75                  80  


Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu 
                85                  90                  95      


Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr 
            100                 105                 110         


Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln 
        115                 120                 125             


Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro 
    130                 135                 140                 


Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val 
145                 150                 155                 160 


Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val 
                165                 170                 175     


Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu 
            180                 185                 190         


Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr 
        195                 200                 205             


Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Leu 
    210                 215                 220                 


Tyr Pro Lys Pro Thr Leu Thr Ala His Pro Gly Pro Ile Met Ala Pro 
225                 230                 235                 240 


Gly Glu Ser Leu Asn Leu Arg Cys Gln Gly Pro Ile Tyr Gly Met Thr 
                245                 250                 255     


Phe Ala Leu Met Arg Val Glu Asp Leu Glu Lys Ser Phe Tyr His Lys 
            260                 265                 270         


Lys Thr Ile Lys Asn Glu Ala Asn Phe Phe Phe Gln Ser Leu Lys Ile 
        275                 280                 285             


Gln Asp Thr Gly His Tyr Leu Cys Phe Tyr Tyr Asp Ala Ser Tyr Arg 
    290                 295                 300                 


Gly Ser Leu Leu Ser Asp Val Leu Lys Ile Trp Val Thr Asp Thr Phe 
305                 310                 315                 320 


Pro Lys Thr Trp Leu Leu Ala Arg Pro Ser Ala Val Val Gln Met Gly 
                325                 330                 335     


Gln Asn Val Ser Leu Arg Cys Arg Gly Pro Val Asp Gly Val Gly Leu 
            340                 345                 350         


Ala Leu Tyr Lys Lys Gly Glu Asp Lys Pro Leu Gln Phe Leu Asp Ala 
        355                 360                 365             


Thr Ser Ile Asp Asp Asn Thr Ser Phe Phe Leu Asn Asn Val Thr Tyr 
    370                 375                 380                 


Ser Asp Thr Gly Ile Tyr Ser Cys His Tyr Leu Leu Thr Trp Lys Thr 
385                 390                 395                 400 


Ser Ile Arg Met Pro Ser His Asn Thr Val Glu Leu Met Val Val Asp 
                405                 410                 415     


Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp Pro Ser Thr Val Phe Lys 
            420                 425                 430         


Leu Gly Lys Ala Ile Thr Leu Gln Cys Arg Val Ser His Pro Val Leu 
        435                 440                 445             


Glu Phe Ser Leu Glu Trp Glu Glu Arg Glu Thr Phe Gln Lys Phe Ser 
    450                 455                 460                 


Val Asn Gly Asp Phe Ile Ile Ser Asn Val Asp Gly Lys Gly Thr Gly 
465                 470                 475                 480 


Thr Tyr Ser Cys Ser Tyr Arg Val Glu Thr His Pro Asn Ile Trp Ser 
                485                 490                 495     


His Arg Ser Glu Pro Leu Lys Leu Met Gly Pro Ala Gly Tyr Leu Thr 
            500                 505                 510         


Trp Asn Tyr Val Leu Asn Glu Ala Ile Arg Leu Ser Leu Ile Met Gln 
        515                 520                 525             


Leu Val Ala Leu Leu Leu Val Val Leu Trp Ile Arg Trp Lys Cys Arg 
    530                 535                 540                 


Arg Leu Arg Ile Arg Glu Ala Trp Leu Leu Gly Thr Ala Gln Gly Val 
545                 550                 555                 560 


Thr Met Leu Phe Ile Val Thr Ala Leu Leu Cys Cys Ala Ile Ser Phe 
                565                 570                 575     


Ala Gly Leu Cys Asn Gly Val Leu Ile Glu Glu Thr Glu Ile Val Met 
            580                 585                 590         


Pro Thr Pro Lys Pro Glu Leu Trp Ala Glu Thr Asn Phe Pro Leu Ala 
        595                 600                 605             


Pro Trp Lys Asn Leu Thr Leu Trp Cys Arg Ser Pro Ser Gly Ser Thr 
    610                 615                 620                 


Lys Glu Phe Val Leu Leu Lys Asp Gly Thr Gly Trp Ile Ala Thr Arg 
625                 630                 635                 640 


Pro Ala Ser Glu Gln Val Arg Ala Ala Phe Pro Leu Gly Ala Leu Thr 
                645                 650                 655     


Gln Ser His Thr Gly Ser Tyr His Cys His Ser Trp Glu Glu Met Ala 
            660                 665                 670         


Val Ser Glu Pro Ser Glu Ala Leu Glu Leu Val Gly Thr Asp Ile Leu 
        675                 680                 685             


Pro Lys Pro Val Ile Ser Ala Ser Pro Thr Ile Arg Gly Gln Glu Leu 
    690                 695                 700                 


Gln Leu Arg Cys Lys Gly Trp Leu Ala Gly Met Gly Phe Ala Leu Tyr 
705                 710                 715                 720 


Lys Glu Gly Glu Gln Glu Pro Val Gln Gln Leu Gly Ala Val Gly Arg 
                725                 730                 735     


Glu Ala Phe Phe Thr Ile Gln Arg Met Glu Asp Lys Asp Glu Gly Asn 
            740                 745                 750         


Tyr Ser Cys Arg Thr His Thr Glu Lys Arg Pro Phe Lys Trp Ser Glu 
        755                 760                 765             


Pro Ser Glu Pro Leu Glu Leu Val Ile Lys Glu Met Tyr Pro Lys Pro 
    770                 775                 780                 


Phe Phe Lys Thr Trp Ala Ser Pro Val Val Thr Pro Gly Ala Arg Val 
785                 790                 795                 800 


Thr Phe Asn Cys Ser Thr Pro His Gln His Met Ser Phe Ile Leu Tyr 
                805                 810                 815     


Lys Asp Gly Ser Glu Ile Ala Ser Ser Asp Arg Ser Trp Ala Ser Pro 
            820                 825                 830         


Gly Ala Ser Ala Ala His Phe Leu Ile Ile Ser Val Gly Ile Gly Asp 
        835                 840                 845             


Gly Gly Asn Tyr Ser Cys Arg Tyr Tyr Asp Phe Ser Ile Trp Ser Glu 
    850                 855                 860                 


Pro Ser Asp Pro Val Glu Leu Val Val Thr Glu Phe Tyr Pro Lys Pro 
865                 870                 875                 880 


Thr Leu Leu Ala Gln Pro Gly Pro Val Val Phe Pro Gly Lys Ser Val 
                885                 890                 895     


Ile Leu Arg Cys Gln Gly Thr Phe Gln Gly Met Arg Phe Ala Leu Leu 
            900                 905                 910         


Gln Glu Gly Ala His Val Pro Leu Gln Phe Arg Ser Val Ser Gly Asn 
        915                 920                 925             


Ser Ala Asp Phe Leu Leu His Thr Val Gly Ala Glu Asp Ser Gly Asn 
    930                 935                 940                 


Tyr Ser Cys Ile Tyr Tyr Glu Thr Thr Met Ser Asn Arg Gly Ser Tyr 
945                 950                 955                 960 


Leu Ser Met Pro Leu Met Ile Trp Val Thr Asp Thr Phe Pro Lys Pro 
                965                 970                 975     


Trp Leu Phe Ala Glu Pro Ser Ser Val Val Pro Met Gly Gln Asn Val 
            980                 985                 990         


Thr Leu Trp Cys Arg Gly Pro Val  His Gly Val Gly Tyr  Ile Leu His 
        995                 1000                 1005             


Lys Glu  Gly Glu Ala Thr Ser  Met Gln Leu Trp Gly  Ser Thr Ser 
    1010                 1015                 1020             


Asn Asp  Gly Ala Phe Pro Ile  Thr Asn Ile Ser Gly  Thr Ser Met 
    1025                 1030                 1035             


Gly Arg  Tyr Ser Cys Cys Tyr  His Pro Asp Trp Thr  Ser Ser Ile 
    1040                 1045                 1050             


Lys Ile  Gln Pro Ser Asn Thr  Leu Glu Leu Leu Val  Thr Gly Leu 
    1055                 1060                 1065             


Leu Pro  Lys Pro Ser Leu Leu  Ala Gln Pro Gly Pro  Met Val Ala 
    1070                 1075                 1080             


Pro Gly  Glu Asn Met Thr Leu  Gln Cys Gln Gly Glu  Leu Pro Asp 
    1085                 1090                 1095             


Ser Thr  Phe Val Leu Leu Lys  Glu Gly Ala Gln Glu  Pro Leu Glu 
    1100                 1105                 1110             


Gln Gln  Arg Pro Ser Gly Tyr  Arg Ala Asp Phe Trp  Met Pro Ala 
    1115                 1120                 1125             


Val Arg  Gly Glu Asp Ser Gly  Ile Tyr Ser Cys Val  Tyr Tyr Leu 
    1130                 1135                 1140             


Asp Ser  Thr Pro Phe Ala Ala  Ser Asn His Ser Asp  Ser Leu Glu 
    1145                 1150                 1155             


Ile Trp  Val Thr Asp Lys Pro  Pro Lys Pro Ser Leu  Ser Ala Trp 
    1160                 1165                 1170             


Pro Ser  Thr Met Phe Lys Leu  Gly Lys Asp Ile Thr  Leu Gln Cys 
    1175                 1180                 1185             


Arg Gly  Pro Leu Pro Gly Val  Glu Phe Val Leu Glu  His Asp Gly 
    1190                 1195                 1200             


Glu Glu  Ala Pro Gln Gln Phe  Ser Glu Asp Gly Asp  Phe Val Ile 
    1205                 1210                 1215             


Asn Asn  Val Glu Gly Lys Gly  Ile Gly Asn Tyr Ser  Cys Ser Tyr 
    1220                 1225                 1230             


Arg Leu  Gln Ala Tyr Pro Asp  Ile Trp Ser Glu Pro  Ser Asp Pro 
    1235                 1240                 1245             


Leu Glu  Leu Val Gly Ala Ala  Gly Pro Val Ala Gln  Glu Cys Thr 
    1250                 1255                 1260             


Val Gly  Asn Ile Val Arg Ser  Ser Leu Ile Val Val  Val Val Val 
    1265                 1270                 1275             


Ala Leu  Gly Val Val Leu Ala  Ile Glu Trp Lys Lys  Trp Pro Arg 
    1280                 1285                 1290             


Leu Arg  Thr Arg Gly Ser Glu  Thr Asp Gly Arg Asp  Gln Thr Ile 
    1295                 1300                 1305             


Ala Leu  Glu Glu Cys Asn Gln  Glu Gly Glu Pro Gly  Thr Pro Ala 
    1310                 1315                 1320             


Asn Ser  Pro Ser Ser Thr Ser  Gln Arg Ile Ser Val  Glu Leu Pro 
    1325                 1330                 1335             


Val Pro  Ile 
    1340     


<210>  5381
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGSF5__Homo_sapiens__NP_001073913

<400>  5381

Met Gly Gln Lys Glu Arg Ser Thr Ala Asp Thr Leu Pro Asp Leu Glu 
1               5                   10                  15      


Glu Trp Lys Ser Ala Ala Gly Leu Arg Trp Trp Gln Thr Ala Val Val 
            20                  25                  30          


Asp Gly Ser Gly Ser Gly Asn Glu Val Ile Glu Gly Pro Gln Asn Ala 
        35                  40                  45              


Arg Val Leu Lys Gly Ser Gln Ala Arg Phe Asn Cys Thr Val Ser Gln 
    50                  55                  60                  


Gly Trp Lys Leu Ile Met Trp Ala Leu Ser Asp Met Val Val Leu Ser 
65                  70                  75                  80  


Val Arg Pro Met Glu Pro Ile Ile Thr Asn Asp Arg Phe Thr Ser Gln 
                85                  90                  95      


Arg Tyr Asp Gln Gly Gly Asn Phe Thr Ser Glu Met Ile Ile His Asn 
            100                 105                 110         


Val Glu Pro Ser Asp Ser Gly Asn Ile Arg Cys Ser Leu Gln Asn Ser 
        115                 120                 125             


Arg Leu His Gly Ser Ala Tyr Leu Thr Val Gln Val Met Gly Glu Leu 
    130                 135                 140                 


Phe Ile Pro Ser Val Asn Leu Val Val Ala Glu Asn Glu Pro Cys Glu 
145                 150                 155                 160 


Val Thr Cys Leu Pro Ser His Trp Thr Arg Leu Pro Asp Ile Ser Trp 
                165                 170                 175     


Glu Leu Gly Leu Leu Val Ser His Ser Ser Tyr Tyr Phe Val Pro Glu 
            180                 185                 190         


Pro Ser Asp Leu Gln Ser Ala Val Ser Ile Leu Ala Leu Thr Pro Gln 
        195                 200                 205             


Ser Asn Gly Thr Leu Thr Cys Val Ala Thr Trp Lys Ser Leu Lys Ala 
    210                 215                 220                 


Arg Lys Ser Ala Thr Val Asn Leu Thr Val Ile Arg Cys Pro Gln Asp 
225                 230                 235                 240 


Thr Gly Gly Gly Ile Asn Ile Pro Gly Val Leu Ser Ser Leu Pro Ser 
                245                 250                 255     


Leu Gly Phe Ser Leu Pro Thr Trp Gly Lys Val Gly Leu Gly Leu Ala 
            260                 265                 270         


Gly Thr Met Leu Leu Thr Pro Thr Cys Thr Leu Thr Ile Arg Cys Cys 
        275                 280                 285             


Cys Cys Arg Arg Arg Cys Cys Gly Cys Asn Cys Cys Cys Arg Cys Cys 
    290                 295                 300                 


Phe Cys Cys Arg Arg Lys Arg Gly Phe Arg Ile Gln Phe Gln Lys Lys 
305                 310                 315                 320 


Ser Glu Lys Glu Lys Thr Asn Lys Glu Thr Glu Thr Glu Ser Gly Asn 
                325                 330                 335     


Glu Asn Ser Gly Tyr Asn Ser Asp Glu Gln Lys Thr Thr Asp Thr Ala 
            340                 345                 350         


Ser Leu Pro Pro Lys Ser Cys Glu Ser Ser Asp Pro Glu Gln Arg Asn 
        355                 360                 365             


Ser Ser Cys Gly Pro Pro His Gln Arg Ala Asp Gln Arg Pro Pro Arg 
    370                 375                 380                 


Pro Ala Ser His Pro Gln Ala Ser Phe Asn Leu Ala Ser Pro Glu Lys 
385                 390                 395                 400 


Val Ser Asn Thr Thr Val Val 
                405         


<210>  5382
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGSF6__Homo_sapiens__NP_005840

<400>  5382

Met Gly Thr Ala Ser Arg Ser Asn Ile Ala Arg His Leu Gln Thr Asn 
1               5                   10                  15      


Leu Ile Leu Phe Cys Val Gly Ala Val Gly Ala Cys Thr Leu Ser Val 
            20                  25                  30          


Thr Gln Pro Trp Tyr Leu Glu Val Asp Tyr Thr His Glu Ala Val Thr 
        35                  40                  45              


Ile Lys Cys Thr Phe Ser Ala Thr Gly Cys Pro Ser Glu Gln Pro Thr 
    50                  55                  60                  


Cys Leu Trp Phe Arg Tyr Gly Ala His Gln Pro Glu Asn Leu Cys Leu 
65                  70                  75                  80  


Asp Gly Cys Lys Ser Glu Ala Asp Lys Phe Thr Val Arg Glu Ala Leu 
                85                  90                  95      


Lys Glu Asn Gln Val Ser Leu Thr Val Asn Arg Val Thr Ser Asn Asp 
            100                 105                 110         


Ser Ala Ile Tyr Ile Cys Gly Ile Ala Phe Pro Ser Val Pro Glu Ala 
        115                 120                 125             


Arg Ala Lys Gln Thr Gly Gly Gly Thr Thr Leu Val Val Arg Glu Ile 
    130                 135                 140                 


Lys Leu Leu Ser Lys Glu Leu Arg Ser Phe Leu Thr Ala Leu Val Ser 
145                 150                 155                 160 


Leu Leu Ser Val Tyr Val Thr Gly Val Cys Val Ala Phe Ile Leu Leu 
                165                 170                 175     


Ser Lys Ser Lys Ser Asn Pro Leu Arg Asn Lys Glu Ile Lys Glu Asp 
            180                 185                 190         


Ser Gln Lys Lys Lys Ser Ala Arg Arg Ile Phe Gln Glu Ile Ala Gln 
        195                 200                 205             


Glu Leu Tyr His Lys Arg His Val Glu Thr Asn Gln Gln Ser Glu Lys 
    210                 215                 220                 


Asp Asn Asn Thr Tyr Glu Asn Arg Arg Val Leu Ser Asn Tyr Glu Arg 
225                 230                 235                 240 


Pro 
    


<210>  5383
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGSF8__Homo_sapiens__NP_001193594

<400>  5383

Met Gly Ala Leu Arg Pro Thr Leu Leu Pro Pro Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Met Leu Gly Met Gly Cys Trp Ala Arg Glu Val Leu Val 
            20                  25                  30          


Pro Glu Gly Pro Leu Tyr Arg Val Ala Gly Thr Ala Val Ser Ile Ser 
        35                  40                  45              


Cys Asn Val Thr Gly Tyr Glu Gly Pro Ala Gln Gln Asn Phe Glu Trp 
    50                  55                  60                  


Phe Leu Tyr Arg Pro Glu Ala Pro Asp Thr Ala Leu Gly Ile Val Ser 
65                  70                  75                  80  


Thr Lys Asp Thr Gln Phe Ser Tyr Ala Val Phe Lys Ser Arg Val Val 
                85                  90                  95      


Ala Gly Glu Val Gln Val Gln Arg Leu Gln Gly Asp Ala Val Val Leu 
            100                 105                 110         


Lys Ile Ala Arg Leu Gln Ala Gln Asp Ala Gly Ile Tyr Glu Cys His 
        115                 120                 125             


Thr Pro Ser Thr Asp Thr Arg Tyr Leu Gly Ser Tyr Ser Gly Lys Val 
    130                 135                 140                 


Glu Leu Arg Val Leu Pro Asp Val Leu Gln Val Ser Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Pro Arg Gly Arg Gln Ala Pro Thr Ser Pro Pro Arg Met Thr Val 
                165                 170                 175     


His Glu Gly Gln Glu Leu Ala Leu Gly Cys Leu Ala Arg Thr Ser Thr 
            180                 185                 190         


Gln Lys His Thr His Leu Ala Val Ser Phe Gly Arg Ser Val Pro Glu 
        195                 200                 205             


Ala Pro Val Gly Arg Ser Thr Leu Gln Glu Val Val Gly Ile Arg Ser 
    210                 215                 220                 


Asp Leu Ala Val Glu Ala Gly Ala Pro Tyr Ala Glu Arg Leu Ala Ala 
225                 230                 235                 240 


Gly Glu Leu Arg Leu Gly Lys Glu Gly Thr Asp Arg Tyr Arg Met Val 
                245                 250                 255     


Val Gly Gly Ala Gln Ala Gly Asp Ala Gly Thr Tyr His Cys Thr Ala 
            260                 265                 270         


Ala Glu Trp Ile Gln Asp Pro Asp Gly Ser Trp Ala Gln Ile Ala Glu 
        275                 280                 285             


Lys Arg Ala Val Leu Ala His Val Asp Val Gln Thr Leu Ser Ser Gln 
    290                 295                 300                 


Leu Ala Val Thr Val Gly Pro Gly Glu Arg Arg Ile Gly Pro Gly Glu 
305                 310                 315                 320 


Pro Leu Glu Leu Leu Cys Asn Val Ser Gly Ala Leu Pro Pro Ala Gly 
                325                 330                 335     


Arg His Ala Ala Tyr Ser Val Gly Trp Glu Met Ala Pro Ala Gly Ala 
            340                 345                 350         


Pro Gly Pro Gly Arg Leu Val Ala Gln Leu Asp Thr Glu Gly Val Gly 
        355                 360                 365             


Ser Leu Gly Pro Gly Tyr Glu Gly Arg His Ile Ala Met Glu Lys Val 
    370                 375                 380                 


Ala Ser Arg Thr Tyr Arg Leu Arg Leu Glu Ala Ala Arg Pro Gly Asp 
385                 390                 395                 400 


Ala Gly Thr Tyr Arg Cys Leu Ala Lys Ala Tyr Val Arg Gly Ser Gly 
                405                 410                 415     


Thr Arg Leu Arg Glu Ala Ala Ser Ala Arg Ser Arg Pro Leu Pro Val 
            420                 425                 430         


His Val Arg Glu Glu Gly Val Val Leu Glu Ala Val Ala Trp Leu Ala 
        435                 440                 445             


Gly Gly Thr Val Tyr Arg Gly Glu Thr Ala Ser Leu Leu Cys Asn Ile 
    450                 455                 460                 


Ser Val Arg Gly Gly Pro Pro Gly Leu Arg Leu Ala Ala Ser Trp Trp 
465                 470                 475                 480 


Val Glu Arg Pro Glu Asp Gly Glu Leu Ser Ser Val Pro Ala Gln Leu 
                485                 490                 495     


Val Gly Gly Val Gly Gln Asp Gly Val Ala Glu Leu Gly Val Arg Pro 
            500                 505                 510         


Gly Gly Gly Pro Val Ser Val Glu Leu Val Gly Pro Arg Ser His Arg 
        515                 520                 525             


Leu Arg Leu His Ser Leu Gly Pro Glu Asp Glu Gly Val Tyr His Cys 
    530                 535                 540                 


Ala Pro Ser Ala Trp Val Gln His Ala Asp Tyr Ser Trp Tyr Gln Ala 
545                 550                 555                 560 


Gly Ser Ala Arg Ser Gly Pro Val Thr Val Tyr Pro Tyr Met His Ala 
                565                 570                 575     


Leu Asp Thr Leu Phe Val Pro Leu Leu Val Gly Thr Gly Val Ala Leu 
            580                 585                 590         


Val Thr Gly Ala Thr Val Leu Gly Thr Ile Thr Cys Cys Phe Met Lys 
        595                 600                 605             


Arg Leu Arg Lys Arg 
    610             


<210>  5384
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IHH__Homo_sapiens__NP_002172

<400>  5384

Met Ser Pro Ala Arg Leu Arg Pro Arg Leu His Phe Cys Leu Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Pro Ala Ala Trp Gly Cys Gly Pro Gly Arg 
            20                  25                  30          


Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys Leu Val Pro Leu Ala 
        35                  40                  45              


Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys Thr Leu Gly Ala Ser 
    50                  55                  60                  


Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser Glu Arg Phe Lys Glu 
65                  70                  75                  80  


Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn 
                85                  90                  95      


Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys Asp Arg Leu Asn 
            100                 105                 110         


Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg 
        115                 120                 125             


Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser Glu Glu Ser Leu 
    130                 135                 140                 


His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg 
145                 150                 155                 160 


Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp 
                165                 170                 175     


Trp Val Tyr Tyr Glu Ser Lys Ala His Val His Cys Ser Val Lys Ser 
            180                 185                 190         


Glu His Ser Ala Ala Ala Lys Thr Gly Gly Cys Phe Pro Ala Gly Ala 
        195                 200                 205             


Gln Val Arg Leu Glu Ser Gly Ala Arg Val Ala Leu Ser Ala Val Arg 
    210                 215                 220                 


Pro Gly Asp Arg Val Leu Ala Met Gly Glu Asp Gly Ser Pro Thr Phe 
225                 230                 235                 240 


Ser Asp Val Leu Ile Phe Leu Asp Arg Glu Pro His Arg Leu Arg Ala 
                245                 250                 255     


Phe Gln Val Ile Glu Thr Gln Asp Pro Pro Arg Arg Leu Ala Leu Thr 
            260                 265                 270         


Pro Ala His Leu Leu Phe Thr Ala Asp Asn His Thr Glu Pro Ala Ala 
        275                 280                 285             


Arg Phe Arg Ala Thr Phe Ala Ser His Val Gln Pro Gly Gln Tyr Val 
    290                 295                 300                 


Leu Val Ala Gly Val Pro Gly Leu Gln Pro Ala Arg Val Ala Ala Val 
305                 310                 315                 320 


Ser Thr His Val Ala Leu Gly Ala Tyr Ala Pro Leu Thr Lys His Gly 
                325                 330                 335     


Thr Leu Val Val Glu Asp Val Val Ala Ser Cys Phe Ala Ala Val Ala 
            340                 345                 350         


Asp His His Leu Ala Gln Leu Ala Phe Trp Pro Leu Arg Leu Phe His 
        355                 360                 365             


Ser Leu Ala Trp Gly Ser Trp Thr Pro Gly Glu Gly Val His Trp Tyr 
    370                 375                 380                 


Pro Gln Leu Leu Tyr Arg Leu Gly Arg Leu Leu Leu Glu Glu Gly Ser 
385                 390                 395                 400 


Phe His Pro Leu Gly Met Ser Gly Ala Gly Ser 
                405                 410     


<210>  5385
<211>  1332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKBKAP__Homo_sapiens__NP_003631

<400>  5385

Met Arg Asn Leu Lys Leu Phe Arg Thr Leu Glu Phe Arg Asp Ile Gln 
1               5                   10                  15      


Gly Pro Gly Asn Pro Gln Cys Phe Ser Leu Arg Thr Glu Gln Gly Thr 
            20                  25                  30          


Val Leu Ile Gly Ser Glu His Gly Leu Ile Glu Val Asp Pro Val Ser 
        35                  40                  45              


Arg Glu Val Lys Asn Glu Val Ser Leu Val Ala Glu Gly Phe Leu Pro 
    50                  55                  60                  


Glu Asp Gly Ser Gly Arg Ile Val Gly Val Gln Asp Leu Leu Asp Gln 
65                  70                  75                  80  


Glu Ser Val Cys Val Ala Thr Ala Ser Gly Asp Val Ile Leu Cys Ser 
                85                  90                  95      


Leu Ser Thr Gln Gln Leu Glu Cys Val Gly Ser Val Ala Ser Gly Ile 
            100                 105                 110         


Ser Val Met Ser Trp Ser Pro Asp Gln Glu Leu Val Leu Leu Ala Thr 
        115                 120                 125             


Gly Gln Gln Thr Leu Ile Met Met Thr Lys Asp Phe Glu Pro Ile Leu 
    130                 135                 140                 


Glu Gln Gln Ile His Gln Asp Asp Phe Gly Glu Ser Lys Phe Ile Thr 
145                 150                 155                 160 


Val Gly Trp Gly Arg Lys Glu Thr Gln Phe His Gly Ser Glu Gly Arg 
                165                 170                 175     


Gln Ala Ala Phe Gln Met Gln Met His Glu Ser Ala Leu Pro Trp Asp 
            180                 185                 190         


Asp His Arg Pro Gln Val Thr Trp Arg Gly Asp Gly Gln Phe Phe Ala 
        195                 200                 205             


Val Ser Val Val Cys Pro Glu Thr Gly Ala Arg Lys Val Arg Val Trp 
    210                 215                 220                 


Asn Arg Glu Phe Ala Leu Gln Ser Thr Ser Glu Pro Val Ala Gly Leu 
225                 230                 235                 240 


Gly Pro Ala Leu Ala Trp Lys Pro Ser Gly Ser Leu Ile Ala Ser Thr 
                245                 250                 255     


Gln Asp Lys Pro Asn Gln Gln Asp Ile Val Phe Phe Glu Lys Asn Gly 
            260                 265                 270         


Leu Leu His Gly His Phe Thr Leu Pro Phe Leu Lys Asp Glu Val Lys 
        275                 280                 285             


Val Asn Asp Leu Leu Trp Asn Ala Asp Ser Ser Val Leu Ala Val Trp 
    290                 295                 300                 


Leu Glu Asp Leu Gln Arg Glu Glu Ser Ser Ile Pro Lys Thr Cys Val 
305                 310                 315                 320 


Gln Leu Trp Thr Val Gly Asn Tyr His Trp Tyr Leu Lys Gln Ser Leu 
                325                 330                 335     


Ser Phe Ser Thr Cys Gly Lys Ser Lys Ile Val Ser Leu Met Trp Asp 
            340                 345                 350         


Pro Val Thr Pro Tyr Arg Leu His Val Leu Cys Gln Gly Trp His Tyr 
        355                 360                 365             


Leu Ala Tyr Asp Trp His Trp Thr Thr Asp Arg Ser Val Gly Asp Asn 
    370                 375                 380                 


Ser Ser Asp Leu Ser Asn Val Ala Val Ile Asp Gly Asn Arg Val Leu 
385                 390                 395                 400 


Val Thr Val Phe Arg Gln Thr Val Val Pro Pro Pro Met Cys Thr Tyr 
                405                 410                 415     


Gln Leu Leu Phe Pro His Pro Val Asn Gln Val Thr Phe Leu Ala His 
            420                 425                 430         


Pro Gln Lys Ser Asn Asp Leu Ala Val Leu Asp Ala Ser Asn Gln Ile 
        435                 440                 445             


Ser Val Tyr Lys Cys Gly Asp Cys Pro Ser Ala Asp Pro Thr Val Lys 
    450                 455                 460                 


Leu Gly Ala Val Gly Gly Ser Gly Phe Lys Val Cys Leu Arg Thr Pro 
465                 470                 475                 480 


His Leu Glu Lys Arg Tyr Lys Ile Gln Phe Glu Asn Asn Glu Asp Gln 
                485                 490                 495     


Asp Val Asn Pro Leu Lys Leu Gly Leu Leu Thr Trp Ile Glu Glu Asp 
            500                 505                 510         


Val Phe Leu Ala Val Ser His Ser Glu Phe Ser Pro Arg Ser Val Ile 
        515                 520                 525             


His His Leu Thr Ala Ala Ser Ser Glu Met Asp Glu Glu His Gly Gln 
    530                 535                 540                 


Leu Asn Val Ser Ser Ser Ala Ala Val Asp Gly Val Ile Ile Ser Leu 
545                 550                 555                 560 


Cys Cys Asn Ser Lys Thr Lys Ser Val Val Leu Gln Leu Ala Asp Gly 
                565                 570                 575     


Gln Ile Phe Lys Tyr Leu Trp Glu Ser Pro Ser Leu Ala Ile Lys Pro 
            580                 585                 590         


Trp Lys Asn Ser Gly Gly Phe Pro Val Arg Phe Pro Tyr Pro Cys Thr 
        595                 600                 605             


Gln Thr Glu Leu Ala Met Ile Gly Glu Glu Glu Cys Val Leu Gly Leu 
    610                 615                 620                 


Thr Asp Arg Cys Arg Phe Phe Ile Asn Asp Ile Glu Val Ala Ser Asn 
625                 630                 635                 640 


Ile Thr Ser Phe Ala Val Tyr Asp Glu Phe Leu Leu Leu Thr Thr His 
                645                 650                 655     


Ser His Thr Cys Gln Cys Phe Cys Leu Arg Asp Ala Ser Phe Lys Thr 
            660                 665                 670         


Leu Gln Ala Gly Leu Ser Ser Asn His Val Ser His Gly Glu Val Leu 
        675                 680                 685             


Arg Lys Val Glu Arg Gly Ser Arg Ile Val Thr Val Val Pro Gln Asp 
    690                 695                 700                 


Thr Lys Leu Val Leu Gln Met Pro Arg Gly Asn Leu Glu Val Val His 
705                 710                 715                 720 


His Arg Ala Leu Val Leu Ala Gln Ile Arg Lys Trp Leu Asp Lys Leu 
                725                 730                 735     


Met Phe Lys Glu Ala Phe Glu Cys Met Arg Lys Leu Arg Ile Asn Leu 
            740                 745                 750         


Asn Leu Ile Tyr Asp His Asn Pro Lys Val Phe Leu Gly Asn Val Glu 
        755                 760                 765             


Thr Phe Ile Lys Gln Ile Asp Ser Val Asn His Ile Asn Leu Phe Phe 
    770                 775                 780                 


Thr Glu Leu Lys Glu Glu Asp Val Thr Lys Thr Met Tyr Pro Ala Pro 
785                 790                 795                 800 


Val Thr Ser Ser Val Tyr Leu Ser Arg Asp Pro Asp Gly Asn Lys Ile 
                805                 810                 815     


Asp Leu Val Cys Asp Ala Met Arg Ala Val Met Glu Ser Ile Asn Pro 
            820                 825                 830         


His Lys Tyr Cys Leu Ser Ile Leu Thr Ser His Val Lys Lys Thr Thr 
        835                 840                 845             


Pro Glu Leu Glu Ile Val Leu Gln Lys Val His Glu Leu Gln Gly Asn 
    850                 855                 860                 


Ala Pro Ser Asp Pro Asp Ala Val Ser Ala Glu Glu Ala Leu Lys Tyr 
865                 870                 875                 880 


Leu Leu His Leu Val Asp Val Asn Glu Leu Tyr Asp His Ser Leu Gly 
                885                 890                 895     


Thr Tyr Asp Phe Asp Leu Val Leu Met Val Ala Glu Lys Ser Gln Lys 
            900                 905                 910         


Asp Pro Lys Glu Tyr Leu Pro Phe Leu Asn Thr Leu Lys Lys Met Glu 
        915                 920                 925             


Thr Asn Tyr Gln Arg Phe Thr Ile Asp Lys Tyr Leu Lys Arg Tyr Glu 
    930                 935                 940                 


Lys Ala Ile Gly His Leu Ser Lys Cys Gly Pro Glu Tyr Phe Pro Glu 
945                 950                 955                 960 


Cys Leu Asn Leu Ile Lys Asp Lys Asn Leu Tyr Asn Glu Ala Leu Lys 
                965                 970                 975     


Leu Tyr Ser Pro Ser Ser Gln Gln Tyr Gln Asp Ile Ser Ile Ala Tyr 
            980                 985                 990         


Gly Glu His Leu Met Gln Glu His  Met Tyr Glu Pro Ala  Gly Leu Met 
        995                 1000                 1005             


Phe Ala  Arg Cys Gly Ala His  Glu Lys Ala Leu Ser  Ala Phe Leu 
    1010                 1015                 1020             


Thr Cys  Gly Asn Trp Lys Gln  Ala Leu Cys Val Ala  Ala Gln Leu 
    1025                 1030                 1035             


Asn Phe  Thr Lys Asp Gln Leu  Val Gly Leu Gly Arg  Thr Leu Ala 
    1040                 1045                 1050             


Gly Lys  Leu Val Glu Gln Arg  Lys His Ile Asp Ala  Ala Met Val 
    1055                 1060                 1065             


Leu Glu  Glu Cys Ala Gln Asp  Tyr Glu Glu Ala Val  Leu Leu Leu 
    1070                 1075                 1080             


Leu Glu  Gly Ala Ala Trp Glu  Glu Ala Leu Arg Leu  Val Tyr Lys 
    1085                 1090                 1095             


Tyr Asn  Arg Leu Asp Ile Ile  Glu Thr Asn Val Lys  Pro Ser Ile 
    1100                 1105                 1110             


Leu Glu  Ala Gln Lys Asn Tyr  Met Ala Phe Leu Asp  Ser Gln Thr 
    1115                 1120                 1125             


Ala Thr  Phe Ser Arg His Lys  Lys Arg Leu Leu Val  Val Arg Glu 
    1130                 1135                 1140             


Leu Lys  Glu Gln Ala Gln Gln  Ala Gly Leu Asp Asp  Glu Val Pro 
    1145                 1150                 1155             


His Gly  Gln Glu Ser Asp Leu  Phe Ser Glu Thr Ser  Ser Val Val 
    1160                 1165                 1170             


Ser Gly  Ser Glu Met Ser Gly  Lys Tyr Ser His Ser  Asn Ser Arg 
    1175                 1180                 1185             


Ile Ser  Ala Arg Ser Ser Lys  Asn Arg Arg Lys Ala  Glu Arg Lys 
    1190                 1195                 1200             


Lys His  Ser Leu Lys Glu Gly  Ser Pro Leu Glu Asp  Leu Ala Leu 
    1205                 1210                 1215             


Leu Glu  Ala Leu Ser Glu Val  Val Gln Asn Thr Glu  Asn Leu Lys 
    1220                 1225                 1230             


Asp Glu  Val Tyr His Ile Leu  Lys Val Leu Phe Leu  Phe Glu Phe 
    1235                 1240                 1245             


Asp Glu  Gln Gly Arg Glu Leu  Gln Lys Ala Phe Glu  Asp Thr Leu 
    1250                 1255                 1260             


Gln Leu  Met Glu Arg Ser Leu  Pro Glu Ile Trp Thr  Leu Thr Tyr 
    1265                 1270                 1275             


Gln Gln  Asn Ser Ala Thr Pro  Val Leu Gly Pro Asn  Ser Thr Ala 
    1280                 1285                 1290             


Asn Ser  Ile Met Ala Ser Tyr  Gln Gln Gln Lys Thr  Ser Val Pro 
    1295                 1300                 1305             


Val Leu  Asp Ala Glu Leu Phe  Ile Pro Pro Lys Ile  Asn Arg Arg 
    1310                 1315                 1320             


Thr Gln  Trp Lys Leu Ser Leu  Leu Asp 
    1325                 1330         


<210>  5386
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKBKB__Homo_sapiens__NP_001177649

<400>  5386

Met Phe Ser Gly Gly Cys His Ser Pro Gly Phe Gly Arg Pro Ser Pro 
1               5                   10                  15      


Ala Phe Pro Ala Pro Gly Ser Pro Pro Pro Ala Pro Arg Pro Cys Arg 
            20                  25                  30          


Gln Glu Thr Gly Glu Gln Ile Ala Ile Lys Gln Cys Arg Gln Glu Leu 
        35                  40                  45              


Ser Pro Arg Asn Arg Glu Arg Trp Cys Leu Glu Ile Gln Ile Met Arg 
    50                  55                  60                  


Arg Leu Thr His Pro Asn Val Val Ala Ala Arg Asp Val Pro Glu Gly 
65                  70                  75                  80  


Met Gln Asn Leu Ala Pro Asn Asp Leu Pro Leu Leu Ala Met Glu Tyr 
                85                  90                  95      


Cys Gln Gly Gly Asp Leu Arg Lys Tyr Leu Asn Gln Phe Glu Asn Cys 
            100                 105                 110         


Cys Gly Leu Arg Glu Gly Ala Ile Leu Thr Leu Leu Ser Asp Ile Ala 
        115                 120                 125             


Ser Ala Leu Arg Tyr Leu His Glu Asn Arg Ile Ile His Arg Asp Leu 
    130                 135                 140                 


Lys Pro Glu Asn Ile Val Leu Gln Gln Gly Glu Gln Arg Leu Ile His 
145                 150                 155                 160 


Lys Ile Ile Asp Leu Gly Tyr Ala Lys Glu Leu Asp Gln Gly Ser Leu 
                165                 170                 175     


Cys Thr Ser Phe Val Gly Thr Leu Gln Tyr Leu Ala Pro Glu Leu Leu 
            180                 185                 190         


Glu Gln Gln Lys Tyr Thr Val Thr Val Asp Tyr Trp Ser Phe Gly Thr 
        195                 200                 205             


Leu Ala Phe Glu Cys Ile Thr Gly Phe Arg Pro Phe Leu Pro Asn Trp 
    210                 215                 220                 


Gln Pro Val Gln Trp His Ser Lys Val Arg Gln Lys Ser Glu Val Asp 
225                 230                 235                 240 


Ile Val Val Ser Glu Asp Leu Asn Gly Thr Val Lys Phe Ser Ser Ser 
                245                 250                 255     


Leu Pro Tyr Pro Asn Asn Leu Asn Ser Val Leu Ala Glu Arg Leu Glu 
            260                 265                 270         


Lys Trp Leu Gln Leu Met Leu Met Trp His Pro Arg Gln Arg Gly Thr 
        275                 280                 285             


Asp Pro Thr Tyr Gly Pro Asn Gly Cys Phe Lys Ala Leu Asp Asp Ile 
    290                 295                 300                 


Leu Asn Leu Lys Leu Val His Ile Leu Asn Met Val Thr Gly Thr Ile 
305                 310                 315                 320 


His Thr Tyr Pro Val Thr Glu Asp Glu Ser Leu Gln Ser Leu Lys Ala 
                325                 330                 335     


Arg Ile Gln Gln Asp Thr Gly Ile Pro Glu Glu Asp Gln Glu Leu Leu 
            340                 345                 350         


Gln Glu Ala Gly Leu Ala Leu Ile Pro Asp Lys Pro Ala Thr Gln Cys 
        355                 360                 365             


Ile Ser Asp Gly Lys Leu Asn Glu Gly His Thr Leu Asp Met Asp Leu 
    370                 375                 380                 


Val Phe Leu Phe Asp Asn Ser Lys Ile Thr Tyr Glu Thr Gln Ile Ser 
385                 390                 395                 400 


Pro Arg Pro Gln Pro Glu Ser Val Ser Cys Ile Leu Gln Glu Pro Lys 
                405                 410                 415     


Arg Asn Leu Ala Phe Phe Gln Leu Arg Lys Val Trp Gly Gln Val Trp 
            420                 425                 430         


His Ser Ile Gln Thr Leu Lys Glu Asp Cys Asn Arg Leu Gln Gln Gly 
        435                 440                 445             


Gln Arg Ala Ala Met Met Asn Leu Leu Arg Asn Asn Ser Cys Leu Ser 
    450                 455                 460                 


Lys Met Lys Asn Ser Met Ala Ser Met Ser Gln Gln Leu Lys Ala Lys 
465                 470                 475                 480 


Leu Asp Phe Phe Lys Thr Ser Ile Gln Ile Asp Leu Glu Lys Tyr Ser 
                485                 490                 495     


Glu Gln Thr Glu Phe Gly Ile Thr Ser Asp Lys Leu Leu Leu Ala Trp 
            500                 505                 510         


Arg Glu Met Glu Gln Ala Val Glu Leu Cys Gly Arg Glu Asn Glu Val 
        515                 520                 525             


Lys Leu Leu Val Glu Arg Met Met Ala Leu Gln Thr Asp Ile Val Asp 
    530                 535                 540                 


Leu Gln Arg Ser Pro Met Gly Arg Lys Gln Gly Gly Thr Leu Asp Asp 
545                 550                 555                 560 


Leu Glu Glu Gln Ala Arg Glu Leu Tyr Arg Arg Leu Arg Glu Lys Pro 
                565                 570                 575     


Arg Asp Gln Arg Thr Glu Gly Asp Ser Gln Glu Met Val Arg Leu Leu 
            580                 585                 590         


Leu Gln Ala Ile Gln Ser Phe Glu Lys Lys Val Arg Val Ile Tyr Thr 
        595                 600                 605             


Gln Leu Ser Lys Thr Val Val Cys Lys Gln Lys Ala Leu Glu Leu Leu 
    610                 615                 620                 


Pro Lys Val Glu Glu Val Val Ser Leu Met Asn Glu Asp Glu Lys Thr 
625                 630                 635                 640 


Val Val Arg Leu Gln Glu Lys Arg Gln Lys Glu Leu Trp Asn Leu Leu 
                645                 650                 655     


Lys Ile Ala Cys Ser Lys Val Arg Gly Pro Val Ser Gly Ser Pro Asp 
            660                 665                 670         


Ser Met Asn Ala Ser Arg Leu Ser Gln Pro Gly Gln Leu Met Ser Gln 
        675                 680                 685             


Pro Ser Thr Ala Ser Asn Ser Leu Pro Glu Pro Ala Lys Lys Ser Glu 
    690                 695                 700                 


Glu Leu Val Ala Glu Ala His Asn Leu Cys Thr Leu Leu Glu Asn Ala 
705                 710                 715                 720 


Ile Gln Asp Thr Val Arg Glu Gln Asp Gln Ser Phe Thr Ala Leu Asp 
                725                 730                 735     


Trp Ser Trp Leu Gln Thr Glu Glu Glu Glu His Ser Cys Leu Glu Gln 
            740                 745                 750         


Ala Ser 
        


<210>  5387
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKBKE__Homo_sapiens__NP_001180250

<400>  5387

Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser Val Leu Glu Ser Pro 
1               5                   10                  15      


Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe Leu Val Val Leu Arg 
            20                  25                  30          


Cys Val Val Ala Gly Met Asn His Leu Arg Glu Asn Gly Ile Val His 
        35                  40                  45              


Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu Val Gly Glu Glu Gly 
    50                  55                  60                  


Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala Ala Arg Glu Leu Asp 
65                  70                  75                  80  


Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr Glu Glu Tyr Leu His 
                85                  90                  95      


Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys Pro Gln Gln Lys Ala 
            100                 105                 110         


Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly Val Thr Leu Tyr His 
        115                 120                 125             


Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe Gly Gly Pro Arg Arg 
    130                 135                 140                 


Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu Lys Pro Ala Gly Ala 
145                 150                 155                 160 


Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro Leu Glu Trp Ser Tyr 
                165                 170                 175     


Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly Leu Gln Ser Gln Leu 
            180                 185                 190         


Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu Gln Ala Lys Cys Trp 
        195                 200                 205             


Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp Ile Leu Gln Arg Val 
    210                 215                 220                 


Val Val His Val Phe Ser Leu Ser Gln Ala Val Leu His His Ile Tyr 
225                 230                 235                 240 


Ile His Ala His Asn Thr Ile Ala Ile Phe Gln Glu Ala Val His Lys 
                245                 250                 255     


Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr Leu Phe Glu Gly His 
            260                 265                 270         


Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln His Ile Ala His Thr 
        275                 280                 285             


Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr Ala Ile Pro Lys Gly 
    290                 295                 300                 


Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro Lys Phe Val Pro Lys 
305                 310                 315                 320 


Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys Gly Val Leu Gly Ala 
                325                 330                 335     


Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu Leu Asp Gly Gln Glu 
            340                 345                 350         


Leu Met Phe Arg Gly Leu His Trp Val Met Glu Val Leu Gln Ala Thr 
        355                 360                 365             


Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser Leu Leu Tyr Leu Ser 
    370                 375                 380                 


Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val Ala Gly Thr Pro Glu 
385                 390                 395                 400 


Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg Ser Arg Leu Arg Thr 
                405                 410                 415     


Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn Ile Thr Glu Thr Gln 
            420                 425                 430         


Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val Lys Ser Arg Asp Gln 
        435                 440                 445             


Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln Cys Cys Leu Asp Lys 
    450                 455                 460                 


Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser Arg Met Arg Pro Gly 
465                 470                 475                 480 


Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu Asp Lys Val Asn Phe 
                485                 490                 495     


Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe Gln Glu Glu Cys Val 
            500                 505                 510         


Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly Lys Arg Met Arg Val 
        515                 520                 525             


Val His Glu Thr Arg Asn His Leu Arg Leu Val Gly Cys Ser Val Ala 
    530                 535                 540                 


Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu Ser Leu Ser Lys Leu 
545                 550                 555                 560 


Leu Glu Glu Leu Ser His Gln Leu Leu Gln Asp Arg Ala Lys Gly Ala 
                565                 570                 575     


Gln Ala Ser Pro Pro Pro Ile Ala Pro Tyr Pro Ser Pro Thr Arg Lys 
            580                 585                 590         


Asp Leu Leu Leu His Met Gln Glu Leu Cys Glu Gly Met Lys Leu Leu 
        595                 600                 605             


Ala Ser Asp Leu Leu Asp Asn Asn Arg Ile Ile Glu Arg Leu Asn Arg 
    610                 615                 620                 


Val Pro Ala Pro Pro Asp Val 
625                 630     


<210>  5388
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKBKG__Homo_sapiens__NP_001093326

<400>  5388

Met Ala Leu Val Ile Gln Val Gly Lys Leu Arg Pro Arg Glu Val Arg 
1               5                   10                  15      


Thr Pro Gln Thr Ile Asn Pro Ser Leu Phe Pro Ser Leu Pro Val Lys 
            20                  25                  30          


Leu Ser Ser Ile Ile Glu Val Pro Ser Gly Gly Glu Arg Cys Cys Ser 
        35                  40                  45              


Arg Arg Thr Leu Val Tyr Lys Ala Arg Ala Phe Trp Lys Gly Ala Pro 
    50                  55                  60                  


Leu Pro Cys Trp Met Asn Arg His Leu Trp Lys Ser Gln Leu Cys Glu 
65                  70                  75                  80  


Met Val Gln Pro Ser Gly Gly Pro Ala Ala Asp Gln Asp Val Leu Gly 
                85                  90                  95      


Glu Glu Ser Pro Leu Gly Lys Pro Ala Met Leu His Leu Pro Ser Glu 
            100                 105                 110         


Gln Gly Ala Pro Glu Thr Leu Gln Arg Cys Leu Glu Glu Asn Gln Glu 
        115                 120                 125             


Leu Arg Asp Ala Ile Arg Gln Ser Asn Gln Ile Leu Arg Glu Arg Cys 
    130                 135                 140                 


Glu Glu Leu Leu His Phe Gln Ala Ser Gln Arg Glu Glu Lys Glu Phe 
145                 150                 155                 160 


Leu Met Cys Lys Phe Gln Glu Ala Arg Lys Leu Val Glu Arg Leu Gly 
                165                 170                 175     


Leu Glu Lys Leu Asp Leu Lys Arg Gln Lys Glu Gln Ala Leu Arg Glu 
            180                 185                 190         


Val Glu His Leu Lys Arg Cys Gln Gln Gln Met Ala Glu Asp Lys Ala 
        195                 200                 205             


Ser Val Lys Ala Gln Val Thr Ser Leu Leu Gly Glu Leu Gln Glu Ser 
    210                 215                 220                 


Gln Ser Arg Leu Glu Ala Ala Thr Lys Glu Cys Gln Ala Leu Glu Gly 
225                 230                 235                 240 


Arg Ala Arg Ala Ala Ser Glu Gln Ala Arg Gln Leu Glu Ser Glu Arg 
                245                 250                 255     


Glu Ala Leu Gln Gln Gln His Ser Val Gln Val Asp Gln Leu Arg Met 
            260                 265                 270         


Gln Gly Gln Ser Val Glu Ala Ala Leu Arg Met Glu Arg Gln Ala Ala 
        275                 280                 285             


Ser Glu Glu Lys Arg Lys Leu Ala Gln Leu Gln Val Ala Tyr His Gln 
    290                 295                 300                 


Leu Phe Gln Glu Tyr Asp Asn His Ile Lys Ser Ser Val Val Gly Ser 
305                 310                 315                 320 


Glu Arg Lys Arg Gly Met Gln Leu Glu Asp Leu Lys Gln Gln Leu Gln 
                325                 330                 335     


Gln Ala Glu Glu Ala Leu Val Ala Lys Gln Glu Val Ile Asp Lys Leu 
            340                 345                 350         


Lys Glu Glu Ala Glu Gln His Lys Ile Val Met Glu Thr Val Pro Val 
        355                 360                 365             


Leu Lys Ala Gln Ala Asp Ile Tyr Lys Ala Asp Phe Gln Ala Glu Arg 
    370                 375                 380                 


Gln Ala Arg Glu Lys Leu Ala Glu Lys Lys Glu Leu Leu Gln Glu Gln 
385                 390                 395                 400 


Leu Glu Gln Leu Gln Arg Glu Tyr Ser Lys Leu Lys Ala Ser Cys Gln 
                405                 410                 415     


Glu Ser Ala Arg Ile Glu Asp Met Arg Lys Arg His Val Glu Val Ser 
            420                 425                 430         


Gln Ala Pro Leu Pro Pro Ala Pro Ala Tyr Leu Ser Ser Pro Leu Ala 
        435                 440                 445             


Leu Pro Ser Gln Arg Arg Ser Pro Pro Glu Glu Pro Pro Asp Phe Cys 
    450                 455                 460                 


Cys Pro Lys Cys Gln Tyr Gln Ala Pro Asp Met Asp Thr Leu Gln Ile 
465                 470                 475                 480 


His Val Met Glu Cys Ile Glu 
                485         


<210>  5389
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IK__Homo_sapiens__NP_006074

<400>  5389

Met Pro Glu Arg Asp Ser Glu Pro Phe Ser Asn Pro Leu Ala Pro Asp 
1               5                   10                  15      


Gly His Asp Val Asp Asp Pro His Ser Phe His Gln Ser Lys Leu Thr 
            20                  25                  30          


Asn Glu Asp Phe Arg Lys Leu Leu Met Thr Pro Arg Ala Ala Pro Thr 
        35                  40                  45              


Ser Ala Pro Pro Ser Lys Ser Arg His His Glu Met Pro Arg Glu Tyr 
    50                  55                  60                  


Asn Glu Asp Glu Asp Pro Ala Ala Arg Arg Arg Lys Lys Lys Ser Tyr 
65                  70                  75                  80  


Tyr Ala Lys Leu Arg Gln Gln Glu Ile Glu Arg Glu Arg Glu Leu Ala 
                85                  90                  95      


Glu Lys Tyr Arg Asp Arg Ala Lys Glu Arg Arg Asp Gly Val Asn Lys 
            100                 105                 110         


Asp Tyr Glu Glu Thr Glu Leu Ile Ser Thr Thr Ala Asn Tyr Arg Ala 
        115                 120                 125             


Val Gly Pro Thr Ala Glu Ala Asp Lys Ser Ala Ala Glu Lys Arg Arg 
    130                 135                 140                 


Gln Leu Ile Gln Glu Ser Lys Phe Leu Gly Gly Asp Met Glu His Thr 
145                 150                 155                 160 


His Leu Val Lys Gly Leu Asp Phe Ala Leu Leu Gln Lys Val Arg Ala 
                165                 170                 175     


Glu Ile Ala Ser Lys Glu Lys Glu Glu Glu Glu Leu Met Glu Lys Pro 
            180                 185                 190         


Gln Lys Glu Thr Lys Lys Asp Glu Asp Pro Glu Asn Lys Ile Glu Phe 
        195                 200                 205             


Lys Thr Arg Leu Gly Arg Asn Val Tyr Arg Met Leu Phe Lys Ser Lys 
    210                 215                 220                 


Ala Tyr Glu Arg Asn Glu Leu Phe Leu Pro Gly Arg Met Ala Tyr Val 
225                 230                 235                 240 


Val Asp Leu Asp Asp Glu Tyr Ala Asp Thr Asp Ile Pro Thr Thr Leu 
                245                 250                 255     


Ile Arg Ser Lys Ala Asp Cys Pro Thr Met Glu Ala Gln Thr Thr Leu 
            260                 265                 270         


Thr Thr Asn Asp Ile Val Ile Ser Lys Leu Thr Gln Ile Leu Ser Tyr 
        275                 280                 285             


Leu Arg Gln Gly Thr Arg Asn Lys Lys Leu Lys Lys Lys Asp Lys Gly 
    290                 295                 300                 


Lys Leu Glu Glu Lys Lys Pro Pro Glu Ala Asp Met Asn Ile Phe Glu 
305                 310                 315                 320 


Asp Ile Gly Asp Tyr Val Pro Ser Thr Thr Lys Thr Pro Arg Asp Lys 
                325                 330                 335     


Glu Arg Glu Arg Tyr Arg Glu Arg Glu Arg Asp Arg Glu Arg Asp Arg 
            340                 345                 350         


Asp Arg Asp Arg Glu Arg Glu Arg Glu Arg Asp Arg Glu Arg Glu Arg 
        355                 360                 365             


Glu Arg Asp Arg Glu Arg Glu Glu Glu Lys Lys Arg His Ser Tyr Phe 
    370                 375                 380                 


Glu Lys Pro Lys Val Asp Asp Glu Pro Met Asp Val Asp Lys Gly Pro 
385                 390                 395                 400 


Gly Ser Thr Lys Glu Leu Ile Lys Ser Ile Asn Glu Lys Phe Ala Gly 
                405                 410                 415     


Ser Ala Gly Trp Glu Gly Thr Glu Ser Leu Lys Lys Pro Glu Asp Lys 
            420                 425                 430         


Lys Gln Leu Gly Asp Phe Phe Gly Met Ser Asn Ser Tyr Ala Glu Cys 
        435                 440                 445             


Tyr Pro Ala Thr Met Asp Asp Met Ala Val Asp Ser Asp Glu Glu Val 
    450                 455                 460                 


Asp Tyr Ser Lys Met Asp Gln Gly Asn Lys Lys Gly Pro Leu Gly Arg 
465                 470                 475                 480 


Trp Asp Phe Asp Thr Gln Glu Glu Tyr Ser Glu Tyr Met Asn Asn Lys 
                485                 490                 495     


Glu Ala Leu Pro Lys Ala Ala Phe Gln Tyr Gly Ile Lys Met Ser Glu 
            500                 505                 510         


Gly Arg Lys Thr Arg Arg Phe Lys Glu Thr Asn Asp Lys Ala Glu Leu 
        515                 520                 525             


Asp Arg Gln Trp Lys Lys Ile Ser Ala Ile Ile Glu Lys Arg Lys Lys 
    530                 535                 540                 


Met Glu Ala Asp Gly Val Glu Val Lys Arg Pro Lys Tyr 
545                 550                 555         


<210>  5390
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKZF1__Homo_sapiens__NP_001207697

<400>  5390

Met Asp Ala Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu 
1               5                   10                  15      


Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro 
            20                  25                  30          


Ile Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys 
        35                  40                  45              


Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp 
    50                  55                  60                  


Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu 
65                  70                  75                  80  


Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His 
                85                  90                  95      


Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu 
            100                 105                 110         


Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly 
        115                 120                 125             


Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro 
    130                 135                 140                 


Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
145                 150                 155                 160 


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
                165                 170                 175     


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
            180                 185                 190         


Arg Thr His Ser Gly Asp Lys Gly Leu Ser Asp Thr Pro Tyr Asp Ser 
        195                 200                 205             


Ser Ala Ser Tyr Glu Lys Glu Asn Glu Met Met Lys Ser His Val Met 
    210                 215                 220                 


Asp Gln Ala Ile Asn Asn Ala Ile Asn Tyr Leu Gly Ala Glu Ser Leu 
225                 230                 235                 240 


Arg Pro Leu Val Gln Thr Pro Pro Gly Gly Ser Glu Val Val Pro Val 
                245                 250                 255     


Ile Ser Pro Met Tyr Gln Leu His Lys Pro Leu Ala Glu Gly Thr Pro 
            260                 265                 270         


Arg Ser Asn His Ser Ala Gln Asp Ser Ala Val Glu Asn Leu Leu Leu 
        275                 280                 285             


Leu Ser Lys Ala Lys Leu Val Pro Ser Glu Arg Glu Ala Ser Pro Ser 
    290                 295                 300                 


Asn Ser Cys Gln Asp Ser Thr Asp Thr Glu Ser Asn Asn Glu Glu Gln 
305                 310                 315                 320 


Arg Ser Gly Leu Ile Tyr Leu Thr Asn His Ile Ala Pro His Ala Arg 
                325                 330                 335     


Asn Gly Leu Ser Leu Lys Glu Glu His Arg Ala Tyr Asp Leu Leu Arg 
            340                 345                 350         


Ala Ala Ser Glu Asn Ser Gln Asp Ala Leu Arg Val Val Ser Thr Ser 
        355                 360                 365             


Gly Glu Gln Met Lys Val Tyr Lys Cys Glu His Cys Arg Val Leu Phe 
    370                 375                 380                 


Leu Asp His Val Met Tyr Thr Ile His Met Gly Cys His Gly Phe Arg 
385                 390                 395                 400 


Asp Pro Phe Glu Cys Asn Met Cys Gly Tyr His Ser Gln Asp Arg Tyr 
                405                 410                 415     


Glu Phe Ser Ser His Ile Thr Arg Gly Glu His Arg Phe His Met Ser 
            420                 425                 430         


<210>  5391
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKZF2__Homo_sapiens__NP_001072994

<400>  5391

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Glu Arg 
            100                 105                 110         


Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
        115                 120                 125             


Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys 
    130                 135                 140                 


Pro Phe Cys Ser Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His 
145                 150                 155                 160 


Leu Arg Thr His Ser Val Gly Lys Pro His Lys Cys Asn Tyr Cys Gly 
                165                 170                 175     


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
            180                 185                 190         


His Asn Tyr Leu Gln Asn Val Ser Met Glu Ala Ala Gly Gln Val Met 
        195                 200                 205             


Ser His His Val Pro Pro Met Glu Asp Cys Lys Glu Gln Glu Pro Ile 
    210                 215                 220                 


Met Asp Asn Asn Ile Ser Leu Val Pro Phe Glu Arg Pro Ala Val Ile 
225                 230                 235                 240 


Glu Lys Leu Thr Gly Asn Met Gly Lys Arg Lys Ser Ser Thr Pro Gln 
                245                 250                 255     


Lys Phe Val Gly Glu Lys Leu Met Arg Phe Ser Tyr Pro Asp Ile His 
            260                 265                 270         


Phe Asp Met Asn Leu Thr Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser 
        275                 280                 285             


His Met Met Asp Gln Ala Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala 
    290                 295                 300                 


Glu Ala Leu His Pro Leu Met Gln His Pro Pro Ser Thr Ile Ala Glu 
305                 310                 315                 320 


Val Ala Pro Val Ile Ser Ser Ala Tyr Ser Gln Val Tyr His Pro Asn 
                325                 330                 335     


Arg Ile Glu Arg Pro Ile Ser Arg Glu Thr Ala Asp Ser His Glu Asn 
            340                 345                 350         


Asn Met Asp Gly Pro Ile Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln 
        355                 360                 365             


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser 
    370                 375                 380                 


Glu Ser Ser His Asp Asp His Gln Ser Tyr Gln Gly His Pro Ala Leu 
385                 390                 395                 400 


Asn Pro Lys Arg Lys Gln Ser Pro Ala Tyr Met Lys Glu Asp Val Lys 
                405                 410                 415     


Ala Leu Asp Thr Thr Lys Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr 
            420                 425                 430         


Lys Val Phe Asn Gly Glu Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu 
        435                 440                 445             


His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His Met 
    450                 455                 460                 


Gly Cys His Gly Tyr Arg Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr 
465                 470                 475                 480 


Arg Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu 
                485                 490                 495     


His Thr Phe His 
            500 


<210>  5392
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKZF3__Homo_sapiens__NP_001244337

<400>  5392

Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln 
1               5                   10                  15      


Ser Val Pro Ala Asp Asp Ser Met Lys Val Lys Asp Glu Tyr Ser Glu 
            20                  25                  30          


Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala Glu Glu 
        35                  40                  45              


Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr Glu Asn 
    50                  55                  60                  


Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg Pro Thr 
65                  70                  75                  80  


Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile Ser Phe 
                85                  90                  95      


Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro Phe 
            100                 105                 110         


Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu 
        115                 120                 125             


Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys His Leu 
    130                 135                 140                 


Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His Leu Arg 
145                 150                 155                 160 


Thr His Ser Val Glu Lys Pro Tyr Lys Cys Glu Phe Cys Gly Arg Ser 
                165                 170                 175     


Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys Arg Thr 
            180                 185                 190         


Phe Leu Gln Ser Thr Asp Pro Gly Asp Thr Ala Ser Ala Glu Ala Arg 
        195                 200                 205             


His Ile Lys Ala Glu Met Gly Ser Glu Arg Ala Leu Val Leu Asp Arg 
    210                 215                 220                 


Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro Gln Lys Phe 
225                 230                 235                 240 


Ile Gly Glu Lys Arg His Cys Phe Asp Val Asn Tyr Asn Ser Ser Tyr 
                245                 250                 255     


Met Tyr Glu Lys Glu Ser Glu Leu Ile Gln Thr Arg Met Met Asp Gln 
            260                 265                 270         


Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu Ala Leu Arg Pro 
        275                 280                 285             


Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met Val Pro Val Ile 
    290                 295                 300                 


Ser Ser Met Tyr Pro Ile Ala Leu Thr Arg Ala Glu Met Ser Asn Gly 
305                 310                 315                 320 


Ala Pro Gln Glu Leu Glu Lys Lys Ser Ile His Leu Pro Glu Lys Ser 
                325                 330                 335     


Val Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser Gly His Asp Ser 
            340                 345                 350         


Thr Asp Thr Asp Ser Asn His Glu Glu Arg Gln Asn His Ile Tyr Gln 
        355                 360                 365             


Gln Asn His Met Val Leu Ser Arg Ala Arg Asn Gly Met Pro Leu Leu 
    370                 375                 380                 


Lys Glu Val Pro Arg Ser Tyr Glu Leu Leu Lys Pro Pro Pro Ile Cys 
385                 390                 395                 400 


Pro Arg Asp Ser Val Lys Val Ile Asn Lys Glu Gly Glu Val Met Asp 
                405                 410                 415     


Val Tyr Arg Cys Asp His Cys Arg Val Leu Phe Leu Asp Tyr Val Met 
            420                 425                 430         


Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys 
        435                 440                 445             


Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu Phe Ser Ser His 
    450                 455                 460                 


Ile Ala Arg Gly Glu His Arg Ala Leu Leu Lys 
465                 470                 475 


<210>  5393
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKZF4__Homo_sapiens__NP_071910

<400>  5393

Met His Thr Pro Pro Ala Leu Pro Arg Arg Phe Gln Gly Gly Gly Arg 
1               5                   10                  15      


Val Arg Thr Pro Gly Ser His Arg Gln Gly Lys Asp Asn Leu Glu Arg 
            20                  25                  30          


Asp Pro Ser Gly Gly Cys Val Pro Asp Phe Leu Pro Gln Ala Gln Asp 
        35                  40                  45              


Ser Asn His Phe Ile Met Glu Ser Leu Phe Cys Glu Ser Ser Gly Asp 
    50                  55                  60                  


Ser Ser Leu Glu Lys Glu Phe Leu Gly Ala Pro Val Gly Pro Ser Val 
65                  70                  75                  80  


Ser Thr Pro Asn Ser Gln His Ser Ser Pro Ser Arg Ser Leu Ser Ala 
                85                  90                  95      


Asn Ser Ile Lys Val Glu Met Tyr Ser Asp Glu Glu Ser Ser Arg Leu 
            100                 105                 110         


Leu Gly Pro Asp Glu Arg Leu Leu Glu Lys Asp Asp Ser Val Ile Val 
        115                 120                 125             


Glu Asp Ser Leu Ser Glu Pro Leu Gly Tyr Cys Asp Gly Ser Gly Pro 
    130                 135                 140                 


Glu Pro His Ser Pro Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu Lys 
145                 150                 155                 160 


Cys Asp Val Cys Gly Met Val Cys Ile Gly Pro Asn Val Leu Met Val 
                165                 170                 175     


His Lys Arg Ser His Thr Gly Glu Arg Pro Phe His Cys Asn Gln Cys 
            180                 185                 190         


Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu 
        195                 200                 205             


His Ser Gly Glu Lys Pro Phe Lys Cys Pro Phe Cys Asn Tyr Ala Cys 
    210                 215                 220                 


Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His Ser Val Ser 
225                 230                 235                 240 


Ser Pro Thr Val Gly Lys Pro Tyr Lys Cys Asn Tyr Cys Gly Arg Ser 
                245                 250                 255     


Tyr Lys Gln Gln Ser Thr Leu Glu Glu His Lys Glu Arg Cys His Asn 
            260                 265                 270         


Tyr Leu Gln Ser Leu Ser Thr Glu Ala Gln Ala Leu Ala Gly Gln Pro 
        275                 280                 285             


Gly Asp Glu Ile Arg Asp Leu Glu Met Val Pro Asp Ser Met Leu His 
    290                 295                 300                 


Ser Ser Ser Glu Arg Pro Thr Phe Ile Asp Arg Leu Ala Asn Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Lys Arg Ser Thr Pro Gln Lys Phe Val Gly Glu Lys Gln 
                325                 330                 335     


Met Arg Phe Ser Leu Ser Asp Leu Pro Tyr Asp Val Asn Ser Gly Gly 
            340                 345                 350         


Tyr Glu Lys Asp Val Glu Leu Val Ala His His Ser Leu Glu Pro Gly 
        355                 360                 365             


Phe Gly Ser Ser Leu Ala Phe Val Gly Ala Glu His Leu Arg Pro Leu 
    370                 375                 380                 


Arg Leu Pro Pro Thr Asn Cys Ile Ser Glu Leu Thr Pro Val Ile Ser 
385                 390                 395                 400 


Ser Val Tyr Thr Gln Met Gln Pro Leu Pro Gly Arg Leu Glu Leu Pro 
                405                 410                 415     


Gly Ser Arg Glu Ala Gly Glu Gly Pro Glu Asp Leu Ala Asp Gly Gly 
            420                 425                 430         


Pro Leu Leu Tyr Arg Pro Arg Gly Pro Leu Thr Asp Pro Gly Ala Ser 
        435                 440                 445             


Pro Ser Asn Gly Cys Gln Asp Ser Thr Asp Thr Glu Ser Asn His Glu 
    450                 455                 460                 


Asp Arg Val Ala Gly Val Val Ser Leu Pro Gln Gly Pro Pro Pro Gln 
465                 470                 475                 480 


Pro Pro Pro Thr Ile Val Val Gly Arg His Ser Pro Ala Tyr Ala Lys 
                485                 490                 495     


Glu Asp Pro Lys Pro Gln Glu Gly Leu Leu Arg Gly Thr Pro Gly Pro 
            500                 505                 510         


Ser Lys Glu Val Leu Arg Val Val Gly Glu Ser Gly Glu Pro Val Lys 
        515                 520                 525             


Ala Phe Lys Cys Glu His Cys Arg Ile Leu Phe Leu Asp His Val Met 
    530                 535                 540                 


Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys 
545                 550                 555                 560 


Asn Ile Cys Gly Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His 
                565                 570                 575     


Ile Val Arg Gly Glu His Lys Val Gly 
            580                 585 


<210>  5394
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL10__Homo_sapiens__XP_011507808

<400>  5394

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  5395
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL10RA__Homo_sapiens__NP_001549

<400>  5395

Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
            260                 265                 270         


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
        275                 280                 285             


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
    290                 295                 300                 


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
                325                 330                 335     


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
            340                 345                 350         


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
        355                 360                 365             


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
    370                 375                 380                 


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
385                 390                 395                 400 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
                405                 410                 415     


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
            420                 425                 430         


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
        435                 440                 445             


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
    450                 455                 460                 


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
465                 470                 475                 480 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
                485                 490                 495     


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
            500                 505                 510         


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
        515                 520                 525             


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
    530                 535                 540                 


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
545                 550                 555                 560 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
                565                 570                 575     


Ser Glu 
        


<210>  5396
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL10RB__Homo_sapiens__NP_000619

<400>  5396

Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala 
    210                 215                 220                 


Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Cys Phe Ala Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe 
                245                 250                 255     


Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His 
            260                 265                 270         


Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu 
        275                 280                 285             


Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser 
    290                 295                 300                 


Gly Lys Gln Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly 
305                 310                 315                 320 


Gln Gly Pro Gln Ser 
                325 


<210>  5397
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL11__Homo_sapiens__NP_000632

<400>  5397

Met Asn Cys Val Cys Arg Leu Val Leu Val Val Leu Ser Leu Trp Pro 
1               5                   10                  15      


Asp Thr Ala Val Ala Pro Gly Pro Pro Pro Gly Pro Pro Arg Val Ser 
            20                  25                  30          


Pro Asp Pro Arg Ala Glu Leu Asp Ser Thr Val Leu Leu Thr Arg Ser 
        35                  40                  45              


Leu Leu Ala Asp Thr Arg Gln Leu Ala Ala Gln Leu Arg Asp Lys Phe 
    50                  55                  60                  


Pro Ala Asp Gly Asp His Asn Leu Asp Ser Leu Pro Thr Leu Ala Met 
65                  70                  75                  80  


Ser Ala Gly Ala Leu Gly Ala Leu Gln Leu Pro Gly Val Leu Thr Arg 
                85                  90                  95      


Leu Arg Ala Asp Leu Leu Ser Tyr Leu Arg His Val Gln Trp Leu Arg 
            100                 105                 110         


Arg Ala Gly Gly Ser Ser Leu Lys Thr Leu Glu Pro Glu Leu Gly Thr 
        115                 120                 125             


Leu Gln Ala Arg Leu Asp Arg Leu Leu Arg Arg Leu Gln Leu Leu Met 
    130                 135                 140                 


Ser Arg Leu Ala Leu Pro Gln Pro Pro Pro Asp Pro Pro Ala Pro Pro 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Ser Ala Trp Gly Gly Ile Arg Ala Ala His Ala 
                165                 170                 175     


Ile Leu Gly Gly Leu His Leu Thr Leu Asp Trp Ala Val Arg Gly Leu 
            180                 185                 190         


Leu Leu Leu Lys Thr Arg Leu 
        195                 


<210>  5398
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL11RA__Homo_sapiens__NP_001136256

<400>  5398

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  5399
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12A__Homo_sapiens__NP_000873

<400>  5399

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  5400
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12B__Homo_sapiens__NP_002178

<400>  5400

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  5401
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL12RB1__Homo_sapiens__NP_001276953

<400>  5401

Met Phe Val Gly Leu Phe Ser Leu Leu Ser Phe Asn Val Phe Arg Ser 
1               5                   10                  15      


Gly Asp Gly Val Ala Glu Pro Arg Arg Trp Gln Arg Gly Ser Pro Gly 
            20                  25                  30          


Ala Val Gly Leu Tyr Val Asp Pro Met Glu Pro Leu Val Thr Trp Val 
        35                  40                  45              


Val Pro Leu Leu Phe Leu Phe Leu Leu Ser Arg Gln Gly Ala Ala Cys 
    50                  55                  60                  


Arg Thr Ser Glu Cys Cys Phe Gln Asp Pro Pro Tyr Pro Asp Ala Asp 
65                  70                  75                  80  


Ser Gly Ser Ala Ser Gly Pro Arg Asp Leu Arg Cys Tyr Arg Ile Ser 
                85                  90                  95      


Ser Asp Arg Tyr Glu Cys Ser Trp Gln Tyr Glu Gly Pro Thr Ala Gly 
            100                 105                 110         


Val Ser His Phe Leu Arg Cys Cys Leu Ser Ser Gly Arg Cys Cys Tyr 
        115                 120                 125             


Phe Ala Ala Gly Ser Ala Thr Arg Leu Gln Phe Ser Asp Gln Ala Gly 
    130                 135                 140                 


Val Ser Val Leu Tyr Thr Val Thr Leu Trp Val Glu Ser Trp Ala Arg 
145                 150                 155                 160 


Asn Gln Thr Glu Lys Ser Pro Glu Val Thr Leu Gln Leu Tyr Asn Ser 
                165                 170                 175     


Val Lys Tyr Glu Pro Pro Leu Gly Asp Ile Lys Val Ser Lys Leu Ala 
            180                 185                 190         


Gly Gln Leu Arg Met Glu Trp Glu Thr Pro Asp Asn Gln Val Gly Ala 
        195                 200                 205             


Glu Val Gln Phe Arg His Arg Thr Pro Ser Ser Pro Trp Lys Leu Gly 
    210                 215                 220                 


Asp Cys Gly Pro Gln Asp Asp Asp Thr Glu Ser Cys Leu Cys Pro Leu 
225                 230                 235                 240 


Glu Met Asn Val Ala Gln Glu Phe Gln Leu Arg Arg Arg Gln Leu Gly 
                245                 250                 255     


Ser Gln Gly Ser Ser Trp Ser Lys Trp Ser Ser Pro Val Cys Val Pro 
            260                 265                 270         


Pro Glu Asn Pro Pro Gln Pro Gln Val Arg Phe Ser Val Glu Gln Leu 
        275                 280                 285             


Gly Gln Asp Gly Arg Arg Arg Leu Thr Leu Lys Glu Gln Pro Thr Gln 
    290                 295                 300                 


Leu Glu Leu Pro Glu Gly Cys Gln Gly Leu Ala Pro Gly Thr Glu Val 
305                 310                 315                 320 


Thr Tyr Arg Leu Gln Leu His Met Leu Ser Cys Pro Cys Lys Ala Lys 
                325                 330                 335     


Ala Thr Arg Thr Leu His Leu Gly Lys Met Pro Tyr Leu Ser Gly Ala 
            340                 345                 350         


Ala Tyr Asn Val Ala Val Ile Ser Ser Asn Gln Phe Gly Pro Gly Leu 
        355                 360                 365             


Asn Gln Thr Trp His Ile Pro Ala Asp Thr His Thr Glu Pro Val Ala 
    370                 375                 380                 


Leu Asn Ile Ser Val Gly Thr Asn Gly Thr Thr Met Tyr Trp Pro Ala 
385                 390                 395                 400 


Arg Ala Gln Ser Met Thr Tyr Cys Ile Glu Trp Gln Pro Val Gly Gln 
                405                 410                 415     


Asp Gly Gly Leu Ala Thr Cys Ser Leu Thr Ala Pro Gln Asp Pro Asp 
            420                 425                 430         


Pro Ala Gly Met Ala Thr Tyr Ser Trp Ser Arg Glu Ser Gly Ala Met 
        435                 440                 445             


Gly Gln Glu Lys Cys Tyr Tyr Ile Thr Ile Phe Ala Ser Ala His Pro 
    450                 455                 460                 


Glu Lys Leu Thr Leu Trp Ser Thr Val Leu Ser Thr Tyr His Phe Gly 
465                 470                 475                 480 


Gly Asn Ala Ser Ala Ala Gly Thr Pro His His Val Ser Val Lys Asn 
                485                 490                 495     


His Ser Leu Asp Ser Val Ser Val Asp Trp Ala Pro Ser Leu Leu Ser 
            500                 505                 510         


Thr Cys Pro Gly Val Leu Lys Glu Tyr Val Val Arg Cys Arg Asp Glu 
        515                 520                 525             


Asp Ser Lys Gln Val Ser Glu His Pro Val Gln Pro Thr Glu Thr Gln 
    530                 535                 540                 


Val Thr Leu Ser Gly Leu Arg Ala Gly Val Ala Tyr Thr Val Gln Val 
545                 550                 555                 560 


Arg Ala Asp Thr Ala Trp Leu Arg Gly Val Trp Ser Gln Pro Gln Arg 
                565                 570                 575     


Phe Ser Ile Glu Val Gln Val Ser Asp Trp Leu Ile Phe Phe Ala Ser 
            580                 585                 590         


Leu Gly Ser Phe Leu Ser Ile Leu Leu Val Gly Val Leu Gly Tyr Leu 
        595                 600                 605             


Gly Leu Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro 
    610                 615                 620                 


Cys Ala Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln 
625                 630                 635                 640 


Trp Ile Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala 
                645                 650                 655     


Leu Val Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu 
            660                 665                 670         


Glu Lys Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr 
        675                 680                 685             


Glu Leu Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
    690                 695                 700         


<210>  5402
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL13__Homo_sapiens__NP_002179

<400>  5402

Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210>  5403
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL13RA1__Homo_sapiens__NP_001551

<400>  5403

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  5404
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL13RA2__Homo_sapiens__NP_000631

<400>  5404

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  5405
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL15__Homo_sapiens__NP_000576

<400>  5405

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  5406
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL15RA__Homo_sapiens__NP_001230468

<400>  5406

Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
1               5                   10                  15      


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            20                  25                  30          


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        35                  40                  45              


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
    50                  55                  60                  


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
                85                  90                  95      


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
            100                 105                 110         


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
        115                 120                 125             


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
    130                 135                 140                 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
145                 150                 155                 160 


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
                165                 170                 175     


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
            180                 185                 190         


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
        195                 200                 205             


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
    210                 215                 220                 


Glu Asn Cys Ser His His Leu 
225                 230     


<210>  5407
<211>  1331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL16__Homo_sapiens__NP_001165599

<400>  5407

Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         


Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             


Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 


Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 


Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     


Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         


Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             


Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 


Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 


Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     


Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         


His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             


Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 


Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     


Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         


Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             


Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 


Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 


Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     


Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         


Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             


Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 


Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 


Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     


Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         


Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 
        995                 1000                 1005             


Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 
    1010                 1015                 1020             


Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 
    1025                 1030                 1035             


Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 
    1040                 1045                 1050             


Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 
    1055                 1060                 1065             


Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 
    1070                 1075                 1080             


Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 
    1085                 1090                 1095             


Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 
    1100                 1105                 1110             


Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 
    1115                 1120                 1125             


Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 
    1130                 1135                 1140             


Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 
    1145                 1150                 1155             


Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 
    1160                 1165                 1170             


Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 
    1175                 1180                 1185             


Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 
    1190                 1195                 1200             


Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 
    1205                 1210                 1215             


Ala Ser  Asp Val Ser Val Glu  Ser Thr Glu Ala Thr  Val Cys Thr 
    1220                 1225                 1230             


Val Thr  Leu Glu Lys Met Ser  Ala Gly Leu Gly Phe  Ser Leu Glu 
    1235                 1240                 1245             


Gly Gly  Lys Gly Ser Leu His  Gly Asp Lys Pro Leu  Thr Ile Asn 
    1250                 1255                 1260             


Arg Ile  Phe Lys Gly Ala Ala  Ser Glu Gln Ser Glu  Thr Val Gln 
    1265                 1270                 1275             


Pro Gly  Asp Glu Ile Leu Gln  Leu Gly Gly Thr Ala  Met Gln Gly 
    1280                 1285                 1290             


Leu Thr  Arg Phe Glu Ala Trp  Asn Ile Ile Lys Ala  Leu Pro Asp 
    1295                 1300                 1305             


Gly Pro  Val Thr Ile Val Ile  Arg Arg Lys Ser Leu  Gln Ser Lys 
    1310                 1315                 1320             


Glu Thr  Thr Ala Ala Gly Asp  Ser 
    1325                 1330     


<210>  5408
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17A__Homo_sapiens__NP_002181

<400>  5408

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  5409
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17B__Homo_sapiens__NP_055258

<400>  5409

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  5410
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17C__Homo_sapiens__NP_037410

<400>  5410

Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      


Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          


Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  


Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210>  5411
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17D__Homo_sapiens__NP_612141

<400>  5411

Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala 
1               5                   10                  15      


Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala 
            20                  25                  30          


Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala 
        35                  40                  45              


Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu 
    50                  55                  60                  


Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg 
65                  70                  75                  80  


Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr 
                85                  90                  95      


Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala 
            100                 105                 110         


Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp 
        115                 120                 125             


Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg 
    130                 135                 140                 


Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr 
145                 150                 155                 160 


Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp 
                165                 170                 175     


Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu 
            180                 185                 190         


Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
        195                 200         


<210>  5412
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17F__Homo_sapiens__XP_011512578

<400>  5412

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  5413
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17RA__Homo_sapiens__NP_001276834

<400>  5413

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Gly Pro Gly Ser Glu Lys 
305                 310                 315                 320 


Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala Asp Leu 
                325                 330                 335     


Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr Ser Ala 
            340                 345                 350         


Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln Phe Leu 
        355                 360                 365             


Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu Glu Gln 
    370                 375                 380                 


Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln Lys Gln 
385                 390                 395                 400 


Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser Arg Gly 
                405                 410                 415     


Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro Val Arg 
            420                 425                 430         


Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr Ala Ala 
        435                 440                 445             


Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe Gly Thr 
    450                 455                 460                 


Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp Val Pro 
465                 470                 475                 480 


Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg Phe Glu 
                485                 490                 495     


Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro Gly Arg 
            500                 505                 510         


Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg Ser Pro 
        515                 520                 525             


Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp Trp Gln 
    530                 535                 540                 


Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser Ala Asp 
545                 550                 555                 560 


Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu Pro Leu 
                565                 570                 575     


Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val Arg Glu 
            580                 585                 590         


Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly Glu Glu 
        595                 600                 605             


Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro Arg Gly 
    610                 615                 620                 


Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala Glu Glu 
625                 630                 635                 640 


Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp Gly Ala 
                645                 650                 655     


Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro Leu Leu 
            660                 665                 670         


Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro Val Asp 
        675                 680                 685             


Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser Pro Asp 
    690                 695                 700                 


Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met Leu Ser 
705                 710                 715                 720 


Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys Ser Arg 
                725                 730                 735     


Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu Glu Gln 
            740                 745                 750         


Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser Ser Pro 
        755                 760                 765             


Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu Glu Glu 
    770                 775                 780                 


Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp Leu Glu 
785                 790                 795                 800 


Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu Gln Lys 
                805                 810                 815     


Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro Ser Ala 
            820                 825                 830         


<210>  5414
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17RB__Homo_sapiens__NP_061195

<400>  5414

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  5415
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17RC__Homo_sapiens__NP_001190192

<400>  5415

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala 
                485                 490                 495     


Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly 
            500                 505                 510         


Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro 
        515                 520                 525             


Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln 
    530                 535                 540                 


Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu 
545                 550                 555                 560 


Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys 
                565                 570                 575     


Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro 
            580                 585                 590         


His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu 
        595                 600                 605             


Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu 
    610                 615                 620                 


Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe 
625                 630                 635                 640 


Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro 
                645                 650                 655     


Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser 
            660                 665                 670         


Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr 
        675                 680                 685             


Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly 
    690                 695                 700                 


Asp Gly Thr 
705         


<210>  5416
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17RD__Homo_sapiens__NP_060033

<400>  5416

Met Ala Pro Trp Leu Gln Leu Cys Ser Val Phe Phe Thr Val Asn Ala 
1               5                   10                  15      


Cys Leu Asn Gly Ser Gln Leu Ala Val Ala Ala Gly Gly Ser Gly Arg 
            20                  25                  30          


Ala Arg Gly Ala Asp Thr Cys Gly Trp Arg Gly Val Gly Pro Ala Ser 
        35                  40                  45              


Arg Asn Ser Gly Leu Tyr Asn Ile Thr Phe Lys Tyr Asp Asn Cys Thr 
    50                  55                  60                  


Thr Tyr Leu Asn Pro Val Gly Lys His Val Ile Ala Asp Ala Gln Asn 
65                  70                  75                  80  


Ile Thr Ile Ser Gln Tyr Ala Cys His Asp Gln Val Ala Val Thr Ile 
                85                  90                  95      


Leu Trp Ser Pro Gly Ala Leu Gly Ile Glu Phe Leu Lys Gly Phe Arg 
            100                 105                 110         


Val Ile Leu Glu Glu Leu Lys Ser Glu Gly Arg Gln Cys Gln Gln Leu 
        115                 120                 125             


Ile Leu Lys Asp Pro Lys Gln Leu Asn Ser Ser Phe Lys Arg Thr Gly 
    130                 135                 140                 


Met Glu Ser Gln Pro Phe Leu Asn Met Lys Phe Glu Thr Asp Tyr Phe 
145                 150                 155                 160 


Val Lys Val Val Pro Phe Pro Ser Ile Lys Asn Glu Ser Asn Tyr His 
                165                 170                 175     


Pro Phe Phe Phe Arg Thr Arg Ala Cys Asp Leu Leu Leu Gln Pro Asp 
            180                 185                 190         


Asn Leu Ala Cys Lys Pro Phe Trp Lys Pro Arg Asn Leu Asn Ile Ser 
        195                 200                 205             


Gln His Gly Ser Asp Met Gln Val Ser Phe Asp His Ala Pro His Asn 
    210                 215                 220                 


Phe Gly Phe Arg Phe Phe Tyr Leu His Tyr Lys Leu Lys His Glu Gly 
225                 230                 235                 240 


Pro Phe Lys Arg Lys Thr Cys Lys Gln Glu Gln Thr Thr Glu Thr Thr 
                245                 250                 255     


Ser Cys Leu Leu Gln Asn Val Ser Pro Gly Asp Tyr Ile Ile Glu Leu 
            260                 265                 270         


Val Asp Asp Thr Asn Thr Thr Arg Lys Val Met His Tyr Ala Leu Lys 
        275                 280                 285             


Pro Val His Ser Pro Trp Ala Gly Pro Ile Arg Ala Val Ala Ile Thr 
    290                 295                 300                 


Val Pro Leu Val Val Ile Ser Ala Phe Ala Thr Leu Phe Thr Val Met 
305                 310                 315                 320 


Cys Arg Lys Lys Gln Gln Glu Asn Ile Tyr Ser His Leu Asp Glu Glu 
                325                 330                 335     


Ser Ser Glu Ser Ser Thr Tyr Thr Ala Ala Leu Pro Arg Glu Arg Leu 
            340                 345                 350         


Arg Pro Arg Pro Lys Val Phe Leu Cys Tyr Ser Ser Lys Asp Gly Gln 
        355                 360                 365             


Asn His Met Asn Val Val Gln Cys Phe Ala Tyr Phe Leu Gln Asp Phe 
    370                 375                 380                 


Cys Gly Cys Glu Val Ala Leu Asp Leu Trp Glu Asp Phe Ser Leu Cys 
385                 390                 395                 400 


Arg Glu Gly Gln Arg Glu Trp Val Ile Gln Lys Ile His Glu Ser Gln 
                405                 410                 415     


Phe Ile Ile Val Val Cys Ser Lys Gly Met Lys Tyr Phe Val Asp Lys 
            420                 425                 430         


Lys Asn Tyr Lys His Lys Gly Gly Gly Arg Gly Ser Gly Lys Gly Glu 
        435                 440                 445             


Leu Phe Leu Val Ala Val Ser Ala Ile Ala Glu Lys Leu Arg Gln Ala 
    450                 455                 460                 


Lys Gln Ser Ser Ser Ala Ala Leu Ser Lys Phe Ile Ala Val Tyr Phe 
465                 470                 475                 480 


Asp Tyr Ser Cys Glu Gly Asp Val Pro Gly Ile Leu Asp Leu Ser Thr 
                485                 490                 495     


Lys Tyr Arg Leu Met Asp Asn Leu Pro Gln Leu Cys Ser His Leu His 
            500                 505                 510         


Ser Arg Asp His Gly Leu Gln Glu Pro Gly Gln His Thr Arg Gln Gly 
        515                 520                 525             


Ser Arg Arg Asn Tyr Phe Arg Ser Lys Ser Gly Arg Ser Leu Tyr Val 
    530                 535                 540                 


Ala Ile Cys Asn Met His Gln Phe Ile Asp Glu Glu Pro Asp Trp Phe 
545                 550                 555                 560 


Glu Lys Gln Phe Val Pro Phe His Pro Pro Pro Leu Arg Tyr Arg Glu 
                565                 570                 575     


Pro Val Leu Glu Lys Phe Asp Ser Gly Leu Val Leu Asn Asp Val Met 
            580                 585                 590         


Cys Lys Pro Gly Pro Glu Ser Asp Phe Cys Leu Lys Val Glu Ala Ala 
        595                 600                 605             


Val Leu Gly Ala Thr Gly Pro Ala Asp Ser Gln His Glu Ser Gln His 
    610                 615                 620                 


Gly Gly Leu Asp Gln Asp Gly Glu Ala Arg Pro Ala Leu Asp Gly Ser 
625                 630                 635                 640 


Ala Ala Leu Gln Pro Leu Leu His Thr Val Lys Ala Gly Ser Pro Ser 
                645                 650                 655     


Asp Met Pro Arg Asp Ser Gly Ile Tyr Asp Ser Ser Val Pro Ser Ser 
            660                 665                 670         


Glu Leu Ser Leu Pro Leu Met Glu Gly Leu Ser Thr Asp Gln Thr Glu 
        675                 680                 685             


Thr Ser Ser Leu Thr Glu Ser Val Ser Ser Ser Ser Gly Leu Gly Glu 
    690                 695                 700                 


Glu Glu Pro Pro Ala Leu Pro Ser Lys Leu Leu Ser Ser Gly Ser Cys 
705                 710                 715                 720 


Lys Ala Asp Leu Gly Cys Arg Ser Tyr Thr Asp Glu Leu His Ala Val 
                725                 730                 735     


Ala Pro Leu 
            


<210>  5417
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17RE__Homo_sapiens__NP_001180309

<400>  5417

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Leu His Ala Ser Leu Ser Ser Pro Gly Gly Glu Asp Ala Trp Leu Ile 
        435                 440                 445             


Gly Val Gly Gly Ser Val Pro Ser Gly Val Ala Val Arg Cys Pro Val 
    450                 455                 460                 


Cys Leu Glu Ala Pro Leu Val Ser Gly Cys Leu Leu Gln Thr Pro Gly 
465                 470                 475                 480 


Ala Leu Asp Pro Gly Thr Ala Gly Pro Pro His Pro Thr Gly Cys Cys 
                485                 490                 495     


Ser Gly Pro His Leu Pro Ala Pro Thr Val Arg Pro Gly Pro Ser Ala 
            500                 505                 510         


Ala Ser Ala Pro Pro Ala Arg Gly Gly Leu Gly Gly Ala Ala Ala Pro 
        515                 520                 525             


Gly Gly Ser Ala Gly 
    530             


<210>  5418
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL17REL__Homo_sapiens__NP_001001694

<400>  5418

Met Ser Arg Ser Val Leu Glu Ala Leu Thr Ser Ser Thr Ala Met Gln 
1               5                   10                  15      


Cys Val Pro Ser Asp Gly Cys Ala Met Leu Leu Arg Val Arg Ala Ser 
            20                  25                  30          


Ile Thr Leu His Glu Arg Leu Arg Gly Leu Glu Ala Cys Ala Met Ser 
        35                  40                  45              


Leu Asp Thr Gln Glu Thr Gln Cys Gln Ser Val Trp Val Ala Arg Ala 
    50                  55                  60                  


Ser His Arg Gln Gln Gly Gly Gln Gln Leu Gln Val His Phe Gly Cys 
65                  70                  75                  80  


Phe Ala Val Ser Val Ala Gln His Leu Tyr Val Thr Leu Arg Thr Ile 
                85                  90                  95      


Pro His Phe Cys Gly Val Gln Leu Asp Gln Arg His Leu Val Glu Ala 
            100                 105                 110         


Gly Lys Leu Ser Tyr Trp Val Asp Arg Arg Arg Lys Ala Ile Leu Val 
        115                 120                 125             


Gln Val Pro Arg Ala Ser Gly Ser Pro Asp Tyr Tyr Leu Arg Leu Cys 
    130                 135                 140                 


Leu Lys Arg Phe Thr Cys Glu Asp Ala Gly Ala Pro Val Arg Val Thr 
145                 150                 155                 160 


Ala Asn Ser Val Ser Gln Ala Val Phe Leu Pro Tyr Ser Gln Glu Leu 
                165                 170                 175     


Pro Cys Leu Cys Leu Glu Gly Trp Ser Ala Thr Pro Asp Ala Val Arg 
            180                 185                 190         


Ile Gln Ile Cys Pro Phe Glu Asn Asp Thr Glu Ala Leu Glu Val Leu 
        195                 200                 205             


Trp Asp Thr Val Tyr Tyr His Pro Glu Ser Gln Thr Leu Ser Trp Glu 
    210                 215                 220                 


Pro Ala Cys Pro Val Ser Gly His Val Ser Leu Cys Trp Arg Pro Gly 
225                 230                 235                 240 


Pro Gly Ala Gly Cys Arg Lys Leu Gln Gln Ser Ser Gln Leu Val His 
                245                 250                 255     


Arg Arg Val Gln Tyr Pro Leu Val Asp Thr Gln Pro Gln Leu Cys Leu 
            260                 265                 270         


Lys Phe Ser Thr Ser Trp Gly Ser Trp Val Arg Cys Pro Phe Glu Gln 
        275                 280                 285             


Arg Arg Phe Pro Thr Pro Pro Thr Ser Arg Cys Thr Cys Val Thr Gly 
    290                 295                 300                 


Gly Ser His Ser Ser Leu Pro Ala Asn Ala His Ser Arg Pro Ala Arg 
305                 310                 315                 320 


Ser Leu Gln Pro Gln Val Thr Trp Gln Pro Pro Leu Leu Leu Pro Ser 
                325                 330                 335     


<210>  5419
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL18BP__Homo_sapiens__NP_001034749

<400>  5419

Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 
1               5                   10                  15      


Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 
            20                  25                  30          


Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 
        35                  40                  45              


Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 
    50                  55                  60                  


Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 
65                  70                  75                  80  


Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 
                85                  90                  95      


Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 
            100                 105                 110         


Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 
        115                 120                 125             


Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 
    130                 135                 140                 


Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 
145                 150                 155                 160 


Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 
                165                 170                 175     


Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 
            180                 185                 190         


Gln Gly 
        


<210>  5420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL18__Homo_sapiens__NP_001230140

<400>  5420

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Glu Asn Leu Glu Ser Asp 
            20                  25                  30          


Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
        35                  40                  45              


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
    50                  55                  60                  


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
65                  70                  75                  80  


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
                85                  90                  95      


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
            100                 105                 110         


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
        115                 120                 125             


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
    130                 135                 140                 


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
145                 150                 155                 160 


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
                165                 170                 175     


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
            180                 185                 


<210>  5421
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL18R1__Homo_sapiens__NP_003846

<400>  5421

Met Asn Cys Arg Glu Leu Pro Leu Thr Leu Trp Val Leu Ile Ser Val 
1               5                   10                  15      


Ser Thr Ala Glu Ser Cys Thr Ser Arg Pro His Ile Thr Val Val Glu 
            20                  25                  30          


Gly Glu Pro Phe Tyr Leu Lys His Cys Ser Cys Ser Leu Ala His Glu 
        35                  40                  45              


Ile Glu Thr Thr Thr Lys Ser Trp Tyr Lys Ser Ser Gly Ser Gln Glu 
    50                  55                  60                  


His Val Glu Leu Asn Pro Arg Ser Ser Ser Arg Ile Ala Leu His Asp 
65                  70                  75                  80  


Cys Val Leu Glu Phe Trp Pro Val Glu Leu Asn Asp Thr Gly Ser Tyr 
                85                  90                  95      


Phe Phe Gln Met Lys Asn Tyr Thr Gln Lys Trp Lys Leu Asn Val Ile 
            100                 105                 110         


Arg Arg Asn Lys His Ser Cys Phe Thr Glu Arg Gln Val Thr Ser Lys 
        115                 120                 125             


Ile Val Glu Val Lys Lys Phe Phe Gln Ile Thr Cys Glu Asn Ser Tyr 
    130                 135                 140                 


Tyr Gln Thr Leu Val Asn Ser Thr Ser Leu Tyr Lys Asn Cys Lys Lys 
145                 150                 155                 160 


Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile Lys Lys Asn Ala Glu 
                165                 170                 175     


Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His Phe Leu His His Asn 
            180                 185                 190         


Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn Ile Thr Ile Val Glu 
        195                 200                 205             


Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly Pro Lys Leu Asn His 
    210                 215                 220                 


Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu Asn Cys Ser Ala Leu 
225                 230                 235                 240 


Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe Gly Glu Glu Asn Gly 
                245                 250                 255     


Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met Arg Ile Met Thr Pro 
            260                 265                 270         


Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg Ile Glu Asn Ile Gly 
        275                 280                 285             


Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr Val Ala Ser Thr Gly 
    290                 295                 300                 


Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg Lys Ala Asp Met Ala 
305                 310                 315                 320 


Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu 
                325                 330                 335     


Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg 
            340                 345                 350         


Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr 
        355                 360                 365             


Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu 
    370                 375                 380                 


Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu 
385                 390                 395                 400 


Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu 
                405                 410                 415     


Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu 
            420                 425                 430         


Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met 
        435                 440                 445             


Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu 
    450                 455                 460                 


Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr 
465                 470                 475                 480 


Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg 
                485                 490                 495     


Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe 
            500                 505                 510         


Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly 
        515                 520                 525             


Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
    530                 535                 540     


<210>  5422
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL18RAP__Homo_sapiens__NP_003844

<400>  5422

Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg 
1               5                   10                  15      


Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp 
            20                  25                  30          


Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu 
        35                  40                  45              


Pro Glu Pro Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro 
    50                  55                  60                  


Lys Gln Val Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser 
65                  70                  75                  80  


Asp Val Gln Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp 
                85                  90                  95      


Ile Arg Lys Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His 
            100                 105                 110         


Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro 
        115                 120                 125             


Lys Met Ile Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile 
    130                 135                 140                 


Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser 
145                 150                 155                 160 


His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro 
                165                 170                 175     


Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr 
            180                 185                 190         


Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val 
        195                 200                 205             


Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr 
    210                 215                 220                 


Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val 
225                 230                 235                 240 


Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro 
                245                 250                 255     


Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser 
            260                 265                 270         


Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys 
        275                 280                 285             


Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu 
    290                 295                 300                 


Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn 
305                 310                 315                 320 


Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val 
                325                 330                 335     


Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu 
            340                 345                 350         


Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile 
        355                 360                 365             


Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His 
    370                 375                 380                 


Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln 
385                 390                 395                 400 


Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys 
                405                 410                 415     


Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
            420                 425                 430         


Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr 
        435                 440                 445             


Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala 
    450                 455                 460                 


Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
465                 470                 475                 480 


Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala 
                485                 490                 495     


Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile 
            500                 505                 510         


Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
        515                 520                 525             


Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
    530                 535                 540                 


Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro 
545                 550                 555                 560 


Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser 
                565                 570                 575     


Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg 
            580                 585                 590         


Ser Ser Gln Pro Lys Glu Trp 
        595                 


<210>  5423
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL19__Homo_sapiens__NP_037503

<400>  5423

Met Lys Leu Gln Cys Val Ser Leu Trp Leu Leu Gly Thr Ile Leu Ile 
1               5                   10                  15      


Leu Cys Ser Val Asp Asn His Gly Leu Arg Arg Cys Leu Ile Ser Thr 
            20                  25                  30          


Asp Met His His Ile Glu Glu Ser Phe Gln Glu Ile Lys Arg Ala Ile 
        35                  40                  45              


Gln Ala Lys Asp Thr Phe Pro Asn Val Thr Ile Leu Ser Thr Leu Glu 
    50                  55                  60                  


Thr Leu Gln Ile Ile Lys Pro Leu Asp Val Cys Cys Val Thr Lys Asn 
65                  70                  75                  80  


Leu Leu Ala Phe Tyr Val Asp Arg Val Phe Lys Asp His Gln Glu Pro 
                85                  90                  95      


Asn Pro Lys Ile Leu Arg Lys Ile Ser Ser Ile Ala Asn Ser Phe Leu 
            100                 105                 110         


Tyr Met Gln Lys Thr Leu Arg Gln Cys Gln Glu Gln Arg Gln Cys His 
        115                 120                 125             


Cys Arg Gln Glu Ala Thr Asn Ala Thr Arg Val Ile His Asp Asn Tyr 
    130                 135                 140                 


Asp Gln Leu Glu Val His Ala Ala Ala Ile Lys Ser Leu Gly Glu Leu 
145                 150                 155                 160 


Asp Val Phe Leu Ala Trp Ile Asn Lys Asn His Glu Val Met Phe Ser 
                165                 170                 175     


Ala 
    


<210>  5424
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1A__Homo_sapiens__NP_000566

<400>  5424

Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210>  5425
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1B__Homo_sapiens__NP_000567

<400>  5425

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  5426
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1F10__Homo_sapiens__NP_115945

<400>  5426

Met Cys Ser Leu Pro Met Ala Arg Tyr Tyr Ile Ile Lys Tyr Ala Asp 
1               5                   10                  15      


Gln Lys Ala Leu Tyr Thr Arg Asp Gly Gln Leu Leu Val Gly Asp Pro 
            20                  25                  30          


Val Ala Asp Asn Cys Cys Ala Glu Lys Ile Cys Ile Leu Pro Asn Arg 
        35                  40                  45              


Gly Leu Ala Arg Thr Lys Val Pro Ile Phe Leu Gly Ile Gln Gly Gly 
    50                  55                  60                  


Ser Arg Cys Leu Ala Cys Val Glu Thr Glu Glu Gly Pro Ser Leu Gln 
65                  70                  75                  80  


Leu Glu Asp Val Asn Ile Glu Glu Leu Tyr Lys Gly Gly Glu Glu Ala 
                85                  90                  95      


Thr Arg Phe Thr Phe Phe Gln Ser Ser Ser Gly Ser Ala Phe Arg Leu 
            100                 105                 110         


Glu Ala Ala Ala Trp Pro Gly Trp Phe Leu Cys Gly Pro Ala Glu Pro 
        115                 120                 125             


Gln Gln Pro Val Gln Leu Thr Lys Glu Ser Glu Pro Ser Ala Arg Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Glu Gln Ser Trp 
145                 150         


<210>  5427
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1R1__Homo_sapiens__XP_011509420

<400>  5427

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  5428
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1R2__Homo_sapiens__NP_004624

<400>  5428

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  5429
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RAP__Homo_sapiens__NP_001161401

<400>  5429

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  5430
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RAPL1__Homo_sapiens__XP_005274498

<400>  5430

Met Lys Ala Pro Ile Pro His Leu Ile Leu Leu Tyr Ala Thr Phe Thr 
1               5                   10                  15      


Gln Ser Leu Lys Val Val Thr Lys Arg Gly Ser Ala Asp Gly Cys Thr 
            20                  25                  30          


Asp Trp Ser Ile Asp Ile Lys Lys Tyr Gln Val Leu Val Gly Glu Pro 
        35                  40                  45              


Val Arg Ile Lys Cys Ala Leu Phe Tyr Gly Tyr Ile Arg Thr Asn Tyr 
    50                  55                  60                  


Ser Leu Ala Gln Ser Ala Gly Leu Ser Leu Met Trp Tyr Lys Ser Ser 
65                  70                  75                  80  


Gly Pro Gly Asp Phe Glu Glu Pro Ile Ala Phe Asp Gly Ser Arg Met 
                85                  90                  95      


Ser Lys Glu Glu Asp Ser Ile Trp Phe Arg Pro Thr Leu Leu Gln Asp 
            100                 105                 110         


Ser Gly Leu Tyr Ala Cys Val Ile Arg Asn Ser Thr Tyr Cys Met Lys 
        115                 120                 125             


Val Ser Ile Ser Leu Thr Val Gly Glu Asn Asp Thr Gly Leu Cys Tyr 
    130                 135                 140                 


Asn Ser Lys Met Lys Tyr Phe Glu Lys Ala Glu Leu Ser Lys Ser Lys 
145                 150                 155                 160 


Glu Ile Ser Cys Arg Asp Ile Glu Asp Phe Leu Leu Pro Thr Arg Glu 
                165                 170                 175     


Pro Glu Ile Leu Trp Tyr Lys Glu Cys Arg Thr Lys Thr Trp Arg Pro 
            180                 185                 190         


Ser Ile Val Phe Lys Arg Asp Thr Leu Leu Ile Arg Glu Val Arg Glu 
        195                 200                 205             


Asp Asp Ile Gly Asn Tyr Thr Cys Glu Leu Lys Tyr Gly Gly Phe Val 
    210                 215                 220                 


Val Arg Arg Thr Thr Glu Leu Thr Val Thr Ala Pro Leu Thr Asp Lys 
225                 230                 235                 240 


Pro Pro Lys Leu Leu Tyr Pro Met Glu Ser Lys Leu Thr Ile Gln Glu 
                245                 250                 255     


Thr Gln Leu Gly Asp Ser Ala Asn Leu Thr Cys Arg Ala Phe Phe Gly 
            260                 265                 270         


Tyr Ser Gly Asp Val Ser Pro Leu Ile Tyr Trp Met Lys Gly Glu Lys 
        275                 280                 285             


Phe Ile Glu Asp Leu Asp Glu Asn Arg Val Trp Glu Ser Asp Ile Arg 
    290                 295                 300                 


Ile Leu Lys Glu His Leu Gly Glu Gln Glu Val Ser Ile Ser Leu Ile 
305                 310                 315                 320 


Val Asp Ser Val Glu Glu Gly Asp Leu Gly Asn Tyr Ser Cys Tyr Val 
                325                 330                 335     


Glu Asn Gly Asn Gly Arg Arg His Ala Ser Val Leu Leu His Lys Arg 
            340                 345                 350         


Glu Leu Met Tyr Thr Val Glu Leu Ala Gly Gly Leu Gly Ala Ile Leu 
        355                 360                 365             


Leu Leu Leu Val Cys Leu Val Thr Ile Tyr Lys Cys Tyr Lys Ile Glu 
    370                 375                 380                 


Ile Met Leu Phe Tyr Arg Asn His Phe Gly Ala Glu Glu Leu Asp Gly 
385                 390                 395                 400 


Asp Asn Lys Asp Tyr Asp Ala Tyr Leu Ser Tyr Thr Lys Val Asp Pro 
                405                 410                 415     


Asp Gln Trp Asn Gln Glu Thr Gly Glu Glu Glu Arg Phe Ala Leu Glu 
            420                 425                 430         


Ile Leu Pro Asp Met Leu Glu Lys His Tyr Gly Tyr Lys Leu Phe Ile 
        435                 440                 445             


Pro Asp Arg Asp Leu Ile Pro Thr Gly Thr Tyr Ile Glu Asp Val Ala 
    450                 455                 460                 


Arg Cys Val Asp Gln Ser Lys Arg Leu Ile Ile Val Met Thr Pro Asn 
465                 470                 475                 480 


Tyr Val Val Arg Arg Gly Trp Ser Ile Phe Glu Leu Glu Thr Arg Leu 
                485                 490                 495     


Arg Asn Met Leu Val Thr Gly Glu Ile Lys Val Ile Leu Ile Glu Cys 
            500                 505                 510         


Ser Glu Leu Arg Gly Ile Met Asn Tyr Gln Glu Val Glu Ala Leu Lys 
        515                 520                 525             


His Thr Ile Lys Leu Leu Thr Val Ile Lys Trp His Gly Pro Lys Cys 
    530                 535                 540                 


Asn Lys Leu Asn Ser Lys Phe Trp Lys Arg Leu Gln Tyr Glu Met Pro 
545                 550                 555                 560 


Phe Lys Arg Ile Glu Pro Ile Thr His Glu Gln Ala Leu Asp Val Ser 
                565                 570                 575     


Glu Gln Gly Pro Phe Gly Glu Leu Gln Thr Val Ser Ala Ile Ser Met 
            580                 585                 590         


Ala Ala Ala Thr Ser Thr Ala Leu Ala Thr Ala His Pro Asp Leu Arg 
        595                 600                 605             


Ser Thr Phe His Asn Thr Tyr His Ser Gln Met Arg Gln Lys His Tyr 
    610                 615                 620                 


Tyr Arg Ser Tyr Glu Tyr Asp Val Pro Pro Thr Gly Thr Leu Pro Leu 
625                 630                 635                 640 


Thr Ser Ile Gly Asn Gln His Thr Tyr Cys Asn Ile Pro Met Thr Leu 
                645                 650                 655     


Ile Asn Gly Gln Arg Pro Gln Thr Lys Ser Ser Arg Glu Gln Asn Pro 
            660                 665                 670         


Asp Glu Ala His Thr Asn Ser Ala Ile Leu Pro Leu Leu Pro Arg Glu 
        675                 680                 685             


Thr Ser Ile Ser Ser Val Ile Trp 
    690                 695     


<210>  5431
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RAPL2__Homo_sapiens__NP_059112

<400>  5431

Met Lys Pro Pro Phe Leu Leu Ala Leu Val Val Cys Ser Val Val Ser 
1               5                   10                  15      


Thr Asn Leu Lys Met Val Ser Lys Arg Asn Ser Val Asp Gly Cys Ile 
            20                  25                  30          


Asp Trp Ser Val Asp Leu Lys Thr Tyr Met Ala Leu Ala Gly Glu Pro 
        35                  40                  45              


Val Arg Val Lys Cys Ala Leu Phe Tyr Ser Tyr Ile Arg Thr Asn Tyr 
    50                  55                  60                  


Ser Thr Ala Gln Ser Thr Gly Leu Arg Leu Met Trp Tyr Lys Asn Lys 
65                  70                  75                  80  


Gly Asp Leu Glu Glu Pro Ile Ile Phe Ser Glu Val Arg Met Ser Lys 
                85                  90                  95      


Glu Glu Asp Ser Ile Trp Phe His Ser Ala Glu Ala Gln Asp Ser Gly 
            100                 105                 110         


Phe Tyr Thr Cys Val Leu Arg Asn Ser Thr Tyr Cys Met Lys Val Ser 
        115                 120                 125             


Met Ser Leu Thr Val Ala Glu Asn Glu Ser Gly Leu Cys Tyr Asn Ser 
    130                 135                 140                 


Arg Ile Arg Tyr Leu Glu Lys Ser Glu Val Thr Lys Arg Lys Glu Ile 
145                 150                 155                 160 


Ser Cys Pro Asp Met Asp Asp Phe Lys Lys Ser Asp Gln Glu Pro Asp 
                165                 170                 175     


Val Val Trp Tyr Lys Glu Cys Lys Pro Lys Met Trp Arg Ser Ile Ile 
            180                 185                 190         


Ile Gln Lys Gly Asn Ala Leu Leu Ile Gln Glu Val Gln Glu Glu Asp 
        195                 200                 205             


Gly Gly Asn Tyr Thr Cys Glu Leu Lys Tyr Glu Gly Lys Leu Val Arg 
    210                 215                 220                 


Arg Thr Thr Glu Leu Lys Val Thr Ala Leu Leu Thr Asp Lys Pro Pro 
225                 230                 235                 240 


Lys Pro Leu Phe Pro Met Glu Asn Gln Pro Ser Val Ile Asp Val Gln 
                245                 250                 255     


Leu Gly Lys Pro Leu Asn Ile Pro Cys Lys Ala Phe Phe Gly Phe Ser 
            260                 265                 270         


Gly Glu Ser Gly Pro Met Ile Tyr Trp Met Lys Gly Glu Lys Phe Ile 
        275                 280                 285             


Glu Glu Leu Ala Gly His Ile Arg Glu Gly Glu Ile Arg Leu Leu Lys 
    290                 295                 300                 


Glu His Leu Gly Glu Lys Glu Val Glu Leu Ala Leu Ile Phe Asp Ser 
305                 310                 315                 320 


Val Val Glu Ala Asp Leu Ala Asn Tyr Thr Cys His Val Glu Asn Arg 
                325                 330                 335     


Asn Gly Arg Lys His Ala Ser Val Leu Leu Arg Lys Lys Asp Leu Ile 
            340                 345                 350         


Tyr Lys Ile Glu Leu Ala Gly Gly Leu Gly Ala Ile Phe Leu Leu Leu 
        355                 360                 365             


Val Leu Leu Val Val Ile Tyr Lys Cys Tyr Asn Ile Glu Leu Met Leu 
    370                 375                 380                 


Phe Tyr Arg Gln His Phe Gly Ala Asp Glu Thr Asn Asp Asp Asn Lys 
385                 390                 395                 400 


Glu Tyr Asp Ala Tyr Leu Ser Tyr Thr Lys Val Asp Gln Asp Thr Leu 
                405                 410                 415     


Asp Cys Asp Asn Pro Glu Glu Glu Gln Phe Ala Leu Glu Val Leu Pro 
            420                 425                 430         


Asp Val Leu Glu Lys His Tyr Gly Tyr Lys Leu Phe Ile Pro Glu Arg 
        435                 440                 445             


Asp Leu Ile Pro Ser Gly Thr Tyr Met Glu Asp Leu Thr Arg Tyr Val 
    450                 455                 460                 


Glu Gln Ser Arg Arg Leu Ile Ile Val Leu Thr Pro Asp Tyr Ile Leu 
465                 470                 475                 480 


Arg Arg Gly Trp Ser Ile Phe Glu Leu Glu Ser Arg Leu His Asn Met 
                485                 490                 495     


Leu Val Ser Gly Glu Ile Lys Val Ile Leu Ile Glu Cys Thr Glu Leu 
            500                 505                 510         


Lys Gly Lys Val Asn Cys Gln Glu Val Glu Ser Leu Lys Arg Ser Ile 
        515                 520                 525             


Lys Leu Leu Ser Leu Ile Lys Trp Lys Gly Ser Lys Ser Ser Lys Leu 
    530                 535                 540                 


Asn Ser Lys Phe Trp Lys His Leu Val Tyr Glu Met Pro Ile Lys Lys 
545                 550                 555                 560 


Lys Glu Met Leu Pro Arg Cys His Val Leu Asp Ser Ala Glu Gln Gly 
                565                 570                 575     


Leu Phe Gly Glu Leu Gln Pro Ile Pro Ser Ile Ala Met Thr Ser Thr 
            580                 585                 590         


Ser Ala Thr Leu Val Ser Ser Gln Ala Asp Leu Pro Glu Phe His Pro 
        595                 600                 605             


Ser Asp Ser Met Gln Ile Arg His Cys Cys Arg Gly Tyr Lys His Glu 
    610                 615                 620                 


Ile Pro Ala Thr Thr Leu Pro Val Pro Ser Leu Gly Asn His His Thr 
625                 630                 635                 640 


Tyr Cys Asn Leu Pro Leu Thr Leu Leu Asn Gly Gln Leu Pro Leu Asn 
                645                 650                 655     


Asn Thr Leu Lys Asp Thr Gln Glu Phe His Arg Asn Ser Ser Leu Leu 
            660                 665                 670         


Pro Leu Ser Ser Lys Glu Leu Ser Phe Thr Ser Asp Ile Trp 
        675                 680                 685     


<210>  5432
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RL1__Homo_sapiens__NP_001269337

<400>  5432

Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn Ser Lys Ile Tyr Cys 
1               5                   10                  15      


Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro Leu Glu Trp Phe Lys 
            20                  25                  30          


Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg Ala His Lys Ser Phe 
        35                  40                  45              


Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala Gly Asp Tyr Thr Cys 
    50                  55                  60                  


Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser Val Thr Ala Thr 
65                  70                  75                  80  


Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe Ser Leu Phe Pro Val 
                85                  90                  95      


Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu Val Glu Ile Gly Lys 
            100                 105                 110         


Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly Lys Gly Thr Gln Phe 
        115                 120                 125             


Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr Lys Ile Thr Asp Phe 
    130                 135                 140                 


Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln Asn Gln Ser Phe Ser 
145                 150                 155                 160 


Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg Ile Ala Asp Val Lys 
                165                 170                 175     


Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu Ala Leu Asn Leu His 
            180                 185                 190         


Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg Lys Asn Pro Ser Lys 
        195                 200                 205             


Glu Cys Phe 
    210     


<210>  5433
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RL2__Homo_sapiens__NP_003845

<400>  5433

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210>  5434
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL1RN__Homo_sapiens__NP_000568

<400>  5434

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  5435
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL20__Homo_sapiens__NP_061194

<400>  5435

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  5436
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL20RA__Homo_sapiens__NP_001265651

<400>  5436

Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly Leu Gln Gly Val 
1               5                   10                  15      


Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly Gln Lys Lys Trp 
            20                  25                  30          


Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr Tyr Cys Asp Leu 
        35                  40                  45              


Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr Ala Lys Val Lys 
    50                  55                  60                  


Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu Ser Gly Arg Phe 
65                  70                  75                  80  


Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu Val Ala Leu Thr 
                85                  90                  95      


Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu Lys Trp 
            100                 105                 110         


Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile Tyr Ser 
        115                 120                 125             


Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn Arg Thr 
    130                 135                 140                 


Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp Leu Glu 
145                 150                 155                 160 


Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro Gly Pro 
                165                 170                 175     


Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr Leu Lys 
            180                 185                 190         


Asp Gln Ser Ser Glu Phe Lys Ala Lys Ile Ile Phe Trp Tyr Val Leu 
        195                 200                 205             


Pro Ile Ser Ile Thr Val Phe Leu Phe Ser Val Met Gly Tyr Ser Ile 
    210                 215                 220                 


Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu Ile 
225                 230                 235                 240 


Leu Ile Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala Glu 
                245                 250                 255     


Lys Ile Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser Lys 
            260                 265                 270         


Ile Ser His Gln Asp Met Ser Leu Leu Gly Lys Ser Ser Asp Val Ser 
        275                 280                 285             


Ser Leu Asn Asp Pro Gln Pro Ser Gly Asn Leu Arg Pro Pro Gln Glu 
    290                 295                 300                 


Glu Glu Glu Val Lys His Leu Gly Tyr Ala Ser His Leu Met Glu Ile 
305                 310                 315                 320 


Phe Cys Asp Ser Glu Glu Asn Thr Glu Gly Thr Ser Leu Thr Gln Gln 
                325                 330                 335     


Glu Ser Leu Ser Arg Thr Ile Pro Pro Asp Lys Thr Val Ile Glu Tyr 
            340                 345                 350         


Glu Tyr Asp Val Arg Thr Thr Asp Ile Cys Ala Gly Pro Glu Glu Gln 
        355                 360                 365             


Glu Leu Ser Leu Gln Glu Glu Val Ser Thr Gln Gly Thr Leu Leu Glu 
    370                 375                 380                 


Ser Gln Ala Ala Leu Ala Val Leu Gly Pro Gln Thr Leu Gln Tyr Ser 
385                 390                 395                 400 


Tyr Thr Pro Gln Leu Gln Asp Leu Asp Pro Leu Ala Gln Glu His Thr 
                405                 410                 415     


Asp Ser Glu Glu Gly Pro Glu Glu Glu Pro Ser Thr Thr Leu Val Asp 
            420                 425                 430         


Trp Asp Pro Gln Thr Gly Arg Leu Cys Ile Pro Ser Leu Ser Ser Phe 
        435                 440                 445             


Asp Gln Asp Ser Glu Gly Cys Glu Pro Ser Glu Gly Asp Gly Leu Gly 
    450                 455                 460                 


Glu Glu Gly Leu Leu Ser Arg Leu Tyr Glu Glu Pro Ala Pro Asp Arg 
465                 470                 475                 480 


Pro Pro Gly Glu Asn Glu Thr Tyr Leu Met Gln Phe Met Glu Glu Trp 
                485                 490                 495     


Gly Leu Tyr Val Gln Met Glu Asn 
            500                 


<210>  5437
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL20RB__Homo_sapiens__NP_653318

<400>  5437

Met Gln Thr Phe Thr Met Val Leu Glu Glu Ile Trp Thr Ser Leu Phe 
1               5                   10                  15      


Met Trp Phe Phe Tyr Ala Leu Ile Pro Cys Leu Leu Thr Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Pro Ala Pro Gln Asn Leu Ser Val Leu Ser Thr Asn Met 
        35                  40                  45              


Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr Val 
    50                  55                  60                  


Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr Ser 
65                  70                  75                  80  


His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro Glu 
                85                  90                  95      


Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu Arg 
            100                 105                 110         


Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser Ile Leu Lys 
        115                 120                 125             


His Pro Phe Asn Arg Asn Ser Thr Ile Leu Thr Arg Pro Gly Met Glu 
    130                 135                 140                 


Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu Gly 
145                 150                 155                 160 


Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly Ala 
                165                 170                 175     


Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro Val His Leu 
            180                 185                 190         


Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala Gln Thr Phe 
        195                 200                 205             


Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr Glu Cys Val 
    210                 215                 220                 


Glu Val Gln Gly Glu Ala Ile Pro Leu Val Leu Ala Leu Phe Ala Phe 
225                 230                 235                 240 


Val Gly Phe Met Leu Ile Leu Val Val Val Pro Leu Phe Val Trp Lys 
                245                 250                 255     


Met Gly Arg Leu Leu Gln Tyr Ser Cys Cys Pro Val Val Val Leu Pro 
            260                 265                 270         


Asp Thr Leu Lys Ile Thr Asn Ser Pro Gln Lys Leu Ile Ser Cys Arg 
        275                 280                 285             


Arg Glu Glu Val Asp Ala Cys Ala Thr Ala Val Met Ser Pro Glu Glu 
    290                 295                 300                 


Leu Leu Arg Ala Trp Ile Ser 
305                 310     


<210>  5438
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL21__Homo_sapiens__NP_068575

<400>  5438

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  5439
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL21R__Homo_sapiens__NP_068570

<400>  5439

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  5440
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22__Homo_sapiens__NP_065386

<400>  5440

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  5441
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL22RA2__Homo_sapiens__NP_443194

<400>  5441

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Met Phe Ser Cys Ser Met Lys Ser Ser His Gln Lys Pro Ser 
65                  70                  75                  80  


Gly Cys Trp Gln His Ile Ser Cys Asn Phe Pro Gly Cys Arg Thr Leu 
                85                  90                  95      


Ala Lys Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
            100                 105                 110         


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
        115                 120                 125             


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
    130                 135                 140                 


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
145                 150                 155                 160 


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
                165                 170                 175     


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
            180                 185                 190         


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
        195                 200                 205             


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
    210                 215                 220                 


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
225                 230                 235                 240 


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
                245                 250                 255     


Glu Arg Cys Val Glu Ile Pro 
            260             


<210>  5442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL23A__Homo_sapiens__XP_011536779

<400>  5442

Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210>  5443
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL23R__Homo_sapiens__XP_011539091

<400>  5443

Met Leu Leu Cys His Gly Ile Leu Phe Pro Trp Ile Gln Val Phe Ala 
1               5                   10                  15      


Arg Lys Leu Gln Glu Gly Asn Ser Leu Phe Leu Leu Pro Asp Met Asn 
            20                  25                  30          


Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile Leu Phe 
        35                  40                  45              


Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly His Ile 
    50                  55                  60                  


Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile Ser Ile 
65                  70                  75                  80  


Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu His Phe 
                85                  90                  95      


Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile Asn Lys 
            100                 105                 110         


Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His Ala Ser 
        115                 120                 125             


Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr Leu Ile 
    130                 135                 140                 


Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro Asp Glu 
145                 150                 155                 160 


Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys Thr Trp 
                165                 170                 175     


Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val His Val 
            180                 185                 190         


Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser Ser Tyr 
        195                 200                 205             


Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr Leu Val 
    210                 215                 220                 


Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys Gln Leu 
225                 230                 235                 240 


Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val Ile Ser 
                245                 250                 255     


Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile Tyr Trp 
            260                 265                 270         


Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg Tyr Lys 
        275                 280                 285             


Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr Asn Phe 
    290                 295                 300                 


Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile Lys Tyr 
305                 310                 315                 320 


Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp Gln Pro 
                325                 330                 335     


Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro Gln Val 
            340                 345                 350         


Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu Thr Val 
        355                 360                 365             


Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly Asp Ile 
    370                 375                 380                 


Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser Ile Leu 
385                 390                 395                 400 


Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile Lys Arg 
                405                 410                 415     


Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile Pro Asn 
            420                 425                 430         


Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser Glu Leu 
        435                 440                 445             


Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro Met Ile 
    450                 455                 460                 


Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr Asp Tyr 
465                 470                 475                 480 


Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro Gln Asn 
                485                 490                 495     


Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu Asn Thr 
            500                 505                 510         


Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser His Leu 
        515                 520                 525             


Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro Val Asp 
    530                 535                 540                 


Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro Asn Phe 
545                 550                 555                 560 


Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile Phe Leu 
                565                 570                 575     


Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser Pro Asp 
            580                 585                 590         


Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu Asn Asp 
        595                 600                 605             


Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp Glu Phe 
    610                 615                 620                 


Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile Asn Thr 
625                 630                 635                 640 


Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile Ser Leu 
                645                 650                 655     


Leu Glu Lys 
            


<210>  5444
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL24__Homo_sapiens__NP_001172085

<400>  5444

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr 
            100                 105                 110         


Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg 
        115                 120                 125             


Thr Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn 
    130                 135                 140                 


Phe Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met 
145                 150                 155                 160 


Phe Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg 
                165                 170                 175     


Ala Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly 
            180                 185                 190         


Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205         


<210>  5445
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL25__Homo_sapiens__NP_073626

<400>  5445

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  5446
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL26__Homo_sapiens__XP_011536870

<400>  5446

Met Leu Val Asn Phe Ile Leu Arg Cys Gly Leu Leu Leu Val Thr Leu 
1               5                   10                  15      


Ser Leu Ala Ile Ala Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys 
            20                  25                  30          


Tyr Pro Arg Gly Thr Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys 
        35                  40                  45              


Ala Ala Trp Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile 
    50                  55                  60                  


Arg Leu Leu Lys Lys Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln 
65                  70                  75                  80  


Phe Gln Glu Gln Leu Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln 
                85                  90                  95      


Leu Gln Leu Gln Gly Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His 
            100                 105                 110         


Ser Leu Arg Gln Lys Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala 
        115                 120                 125             


Arg Glu Met Lys Ser Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile 
    130                 135                 140                 


Gly Asn Lys Gly Ile Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu 
145                 150                 155                 160 


Ser Trp Ile Lys Lys Leu Leu Glu Ser Ser Gln 
                165                 170     


<210>  5447
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL27__Homo_sapiens__NP_663634

<400>  5447

Met Gly Gln Thr Ala Gly Asp Leu Gly Trp Arg Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Leu Val Gln Ala Gly Val Trp Gly Phe Pro Arg Pro 
            20                  25                  30          


Pro Gly Arg Pro Gln Leu Ser Leu Gln Glu Leu Arg Arg Glu Phe Thr 
        35                  40                  45              


Val Ser Leu His Leu Ala Arg Lys Leu Leu Ser Glu Val Arg Gly Gln 
    50                  55                  60                  


Ala His Arg Phe Ala Glu Ser His Leu Pro Gly Val Asn Leu Tyr Leu 
65                  70                  75                  80  


Leu Pro Leu Gly Glu Gln Leu Pro Asp Val Ser Leu Thr Phe Gln Ala 
                85                  90                  95      


Trp Arg Arg Leu Ser Asp Pro Glu Arg Leu Cys Phe Ile Ser Thr Thr 
            100                 105                 110         


Leu Gln Pro Phe His Ala Leu Leu Gly Gly Leu Gly Thr Gln Gly Arg 
        115                 120                 125             


Trp Thr Asn Met Glu Arg Met Gln Leu Trp Ala Met Arg Leu Asp Leu 
    130                 135                 140                 


Arg Asp Leu Gln Arg His Leu Arg Phe Gln Val Leu Ala Ala Gly Phe 
145                 150                 155                 160 


Asn Leu Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                165                 170                 175     


Arg Lys Gly Leu Leu Pro Gly Ala Leu Gly Ser Ala Leu Gln Gly Pro 
            180                 185                 190         


Ala Gln Val Ser Trp Pro Gln Leu Leu Ser Thr Tyr Arg Leu Leu His 
        195                 200                 205             


Ser Leu Glu Leu Val Leu Ser Arg Ala Val Arg Glu Leu Leu Leu Leu 
    210                 215                 220                 


Ser Lys Ala Gly His Ser Val Trp Pro Leu Gly Phe Pro Thr Leu Ser 
225                 230                 235                 240 


Pro Gln Pro 
            


<210>  5448
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL27RA__Homo_sapiens__NP_004834

<400>  5448

Met Arg Gly Gly Arg Gly Ala Pro Phe Trp Leu Trp Pro Leu Pro Lys 
1               5                   10                  15      


Leu Ala Leu Leu Pro Leu Leu Trp Val Leu Phe Gln Arg Thr Arg Pro 
            20                  25                  30          


Gln Gly Ser Ala Gly Pro Leu Gln Cys Tyr Gly Val Gly Pro Leu Gly 
        35                  40                  45              


Asp Leu Asn Cys Ser Trp Glu Pro Leu Gly Asp Leu Gly Ala Pro Ser 
    50                  55                  60                  


Glu Leu His Leu Gln Ser Gln Lys Tyr Arg Ser Asn Lys Thr Gln Thr 
65                  70                  75                  80  


Val Ala Val Ala Ala Gly Arg Ser Trp Val Ala Ile Pro Arg Glu Gln 
                85                  90                  95      


Leu Thr Met Ser Asp Lys Leu Leu Val Trp Gly Thr Lys Ala Gly Gln 
            100                 105                 110         


Pro Leu Trp Pro Pro Val Phe Val Asn Leu Glu Thr Gln Met Lys Pro 
        115                 120                 125             


Asn Ala Pro Arg Leu Gly Pro Asp Val Asp Phe Ser Glu Asp Asp Pro 
    130                 135                 140                 


Leu Glu Ala Thr Val His Trp Ala Pro Pro Thr Trp Pro Ser His Lys 
145                 150                 155                 160 


Val Leu Ile Cys Gln Phe His Tyr Arg Arg Cys Gln Glu Ala Ala Trp 
                165                 170                 175     


Thr Leu Leu Glu Pro Glu Leu Lys Thr Ile Pro Leu Thr Pro Val Glu 
            180                 185                 190         


Ile Gln Asp Leu Glu Leu Ala Thr Gly Tyr Lys Val Tyr Gly Arg Cys 
        195                 200                 205             


Arg Met Glu Lys Glu Glu Asp Leu Trp Gly Glu Trp Ser Pro Ile Leu 
    210                 215                 220                 


Ser Phe Gln Thr Pro Pro Ser Ala Pro Lys Asp Val Trp Val Ser Gly 
225                 230                 235                 240 


Asn Leu Cys Gly Thr Pro Gly Gly Glu Glu Pro Leu Leu Leu Trp Lys 
                245                 250                 255     


Ala Pro Gly Pro Cys Val Gln Val Ser Tyr Lys Val Trp Phe Trp Val 
            260                 265                 270         


Gly Gly Arg Glu Leu Ser Pro Glu Gly Ile Thr Cys Cys Cys Ser Leu 
        275                 280                 285             


Ile Pro Ser Gly Ala Glu Trp Ala Arg Val Ser Ala Val Asn Ala Thr 
    290                 295                 300                 


Ser Trp Glu Pro Leu Thr Asn Leu Ser Leu Val Cys Leu Asp Ser Ala 
305                 310                 315                 320 


Ser Ala Pro Arg Ser Val Ala Val Ser Ser Ile Ala Gly Ser Thr Glu 
                325                 330                 335     


Leu Leu Val Thr Trp Gln Pro Gly Pro Gly Glu Pro Leu Glu His Val 
            340                 345                 350         


Val Asp Trp Ala Arg Asp Gly Asp Pro Leu Glu Lys Leu Asn Trp Val 
        355                 360                 365             


Arg Leu Pro Pro Gly Asn Leu Ser Ala Leu Leu Pro Gly Asn Phe Thr 
    370                 375                 380                 


Val Gly Val Pro Tyr Arg Ile Thr Val Thr Ala Val Ser Ala Ser Gly 
385                 390                 395                 400 


Leu Ala Ser Ala Ser Ser Val Trp Gly Phe Arg Glu Glu Leu Ala Pro 
                405                 410                 415     


Leu Val Gly Pro Thr Leu Trp Arg Leu Gln Asp Ala Pro Pro Gly Thr 
            420                 425                 430         


Pro Ala Ile Ala Trp Gly Glu Val Pro Arg His Gln Leu Arg Gly His 
        435                 440                 445             


Leu Thr His Tyr Thr Leu Cys Ala Gln Ser Gly Thr Ser Pro Ser Val 
    450                 455                 460                 


Cys Met Asn Val Ser Gly Asn Thr Gln Ser Val Thr Leu Pro Asp Leu 
465                 470                 475                 480 


Pro Trp Gly Pro Cys Glu Leu Trp Val Thr Ala Ser Thr Ile Ala Gly 
                485                 490                 495     


Gln Gly Pro Pro Gly Pro Ile Leu Arg Leu His Leu Pro Asp Asn Thr 
            500                 505                 510         


Leu Arg Trp Lys Val Leu Pro Gly Ile Leu Phe Leu Trp Gly Leu Phe 
        515                 520                 525             


Leu Leu Gly Cys Gly Leu Ser Leu Ala Thr Ser Gly Arg Cys Tyr His 
    530                 535                 540                 


Leu Arg His Lys Val Leu Pro Arg Trp Val Trp Glu Lys Val Pro Asp 
545                 550                 555                 560 


Pro Ala Asn Ser Ser Ser Gly Gln Pro His Met Glu Gln Val Pro Glu 
                565                 570                 575     


Ala Gln Pro Leu Gly Asp Leu Pro Ile Leu Glu Val Glu Glu Met Glu 
            580                 585                 590         


Pro Pro Pro Val Met Glu Ser Ser Gln Pro Ala Gln Ala Thr Ala Pro 
        595                 600                 605             


Leu Asp Ser Gly Tyr Glu Lys His Phe Leu Pro Thr Pro Glu Glu Leu 
    610                 615                 620                 


Gly Leu Leu Gly Pro Pro Arg Pro Gln Val Leu Ala 
625                 630                 635     


<210>  5449
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2__Homo_sapiens__NP_000577

<400>  5449

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  5450
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RA__Homo_sapiens__NP_000408

<400>  5450

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  5451
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RB__Homo_sapiens__NP_000869

<400>  5451

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  5452
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RG__Homo_sapiens__NP_000197

<400>  5452

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  5453
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL31__Homo_sapiens__XP_011536628

<400>  5453

Met Ala Ser His Ser Gly Pro Ser Thr Ser Val Leu Phe Leu Phe Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Ala Ser His Thr Leu Pro Val Arg Leu Leu 
            20                  25                  30          


Arg Pro Ser Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu 
        35                  40                  45              


Ser Lys Met Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val 
    50                  55                  60                  


Ser Gln Asn Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro 
65                  70                  75                  80  


Asn Asn Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg 
                85                  90                  95      


Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp 
            100                 105                 110         


Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr 
        115                 120                 125             


Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe 
    130                 135                 140                 


Ser Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln 
145                 150                 155                 160 


Gln Ala Thr Thr 
                


<210>  5454
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL31RA__Homo_sapiens__NP_001229565

<400>  5454

Met Lys Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly Met Met Trp 
1               5                   10                  15      


Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe Ser Leu Ala 
            20                  25                  30          


Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr Tyr Tyr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr Ser Tyr Thr 
    50                  55                  60                  


Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys His Asp Asn 
65                  70                  75                  80  


Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser Cys Ser Phe 
                85                  90                  95      


Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile Glu Val Glu 
            100                 105                 110         


Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr Tyr Trp Arg 
        115                 120                 125             


Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe Arg Val Lys 
    130                 135                 140                 


Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp Ile Lys Pro 
145                 150                 155                 160 


Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu Arg Phe Arg 
                165                 170                 175     


Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala Lys Asn Arg 
            180                 185                 190         


Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln Pro Phe Thr 
        195                 200                 205             


Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser Lys Phe Trp 
    210                 215                 220                 


Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu Glu Ala Pro 
225                 230                 235                 240 


Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu Ala Asp Gly 
                245                 250                 255     


Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly Ala Pro Val 
            260                 265                 270         


Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro Glu Ser Asn 
        275                 280                 285             


Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln Leu Glu Leu 
    290                 295                 300                 


His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser Tyr Asn Ser 
305                 310                 315                 320 


Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala Ile Gln Glu 
                325                 330                 335     


Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val Ala Glu Asp 
            340                 345                 350         


Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val Asn Thr Trp 
        355                 360                 365             


Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr Thr Leu Ser 
    370                 375                 380                 


Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln Gln Asp Lys 
385                 390                 395                 400 


Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro Met Leu His 
                405                 410                 415     


Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala Lys Glu Gly 
            420                 425                 430         


Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile Gly Val Lys 
        435                 440                 445             


Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu Arg Lys Gly 
    450                 455                 460                 


Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly Gly Lys Gly 
465                 470                 475                 480 


Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly Leu Glu Ser 
                485                 490                 495     


Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala Ser Thr Ser 
            500                 505                 510         


Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr Leu Ser Phe 
        515                 520                 525             


Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly Gly Gly Leu 
    530                 535                 540                 


Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys Lys Pro Asn 
545                 550                 555                 560 


Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro Ala Glu Ser 
                565                 570                 575     


Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys Leu Asn Leu 
            580                 585                 590         


Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile Leu Lys Pro 
        595                 600                 605             


Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu Val Val Asn 
    610                 615                 620                 


Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala Arg Thr Gly 
625                 630                 635                 640 


Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Tyr Val Thr Cys Pro 
                645                 650                 655     


Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe Glu Glu Leu Pro Val 
            660                 665                 670         


Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr Leu Arg Ser Arg Met 
        675                 680                 685             


Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln Leu Leu Phe Ser Gly 
    690                 695                 700                 


Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu Gly Ala Pro Asn Pro 
705                 710                 715                 720 


Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe Leu Val Ser Glu Lys 
                725                 730                 735     


Leu Pro Glu His Thr Lys Gly Glu Val 
            740                 745 


<210>  5455
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL32__Homo_sapiens__NP_001012651

<400>  5455

Met Cys Phe Pro Lys Val Leu Ser Asp Asp Met Lys Lys Leu Lys Ala 
1               5                   10                  15      


Arg Met His Gln Ala Ile Glu Arg Phe Tyr Asp Lys Met Gln Asn Ala 
            20                  25                  30          


Glu Ser Gly Arg Gly Gln Val Met Ser Ser Leu Ala Glu Leu Glu Asp 
        35                  40                  45              


Asp Phe Lys Glu Gly Tyr Leu Glu Thr Val Ala Ala Tyr Tyr Glu Glu 
    50                  55                  60                  


Gln His Pro Glu Leu Thr Pro Leu Leu Glu Lys Glu Arg Asp Gly Leu 
65                  70                  75                  80  


Arg Cys Arg Gly Asn Arg Ser Pro Val Pro Asp Val Glu Asp Pro Ala 
                85                  90                  95      


Thr Glu Glu Pro Gly Glu Ser Phe Cys Asp Lys Ser Tyr Gly Ala Pro 
            100                 105                 110         


Arg Gly Asp Lys Glu Glu Leu Thr Pro Gln Lys Cys Ser Glu Pro Gln 
        115                 120                 125             


Ser Ser Lys 
    130     


<210>  5456
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL33__Homo_sapiens__NP_001186569

<400>  5456

Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      


Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          


Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              


Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  


Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  


Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      


Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         


Ile Thr Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser 
        115                 120                 125             


Asn Glu Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu 
    130                 135                 140                 


Ser Pro Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser 
145                 150                 155                 160 


Val Glu Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe 
                165                 170                 175     


Val Leu His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr 
            180                 185                 190         


Asp Pro Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile 
        195                 200                 205             


Lys Val Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys 
    210                 215                 220                 


Leu Ser Glu Thr 
225             


<210>  5457
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL34__Homo_sapiens__XP_011521205

<400>  5457

Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                  15      


Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                  25                  30          


Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                  40                  45              


Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile 
    50                  55                  60                  


Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu 
65                  70                  75                  80  


Gln Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu 
                85                  90                  95      


Val Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly 
            100                 105                 110         


His Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn 
        115                 120                 125             


Val Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser 
    130                 135                 140                 


Val Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg 
145                 150                 155                 160 


Pro Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr 
                165                 170                 175     


Cys Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu 
            180                 185                 190         


Val Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala 
        195                 200                 205             


Ala Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro 
    210                 215                 220                 


His Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu 
225                 230                 235                 240 


Leu Pro 
        


<210>  5458
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL36A__Homo_sapiens__NP_055255

<400>  5458

Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210>  5459
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL36B__Homo_sapiens__NP_055253

<400>  5459

Met Asn Pro Gln Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp 
1               5                   10                  15      


Ser Arg Gln Met Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala 
            20                  25                  30          


Pro Leu Ser Arg Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys 
        35                  40                  45              


Arg Asp Thr Glu Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu 
    50                  55                  60                  


Gly Ile Lys Gly Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly 
65                  70                  75                  80  


Lys Pro Thr Leu Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly 
                85                  90                  95      


Lys Asp Thr Cys Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu 
            100                 105                 110         


Asp Val Arg Glu Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile 
        115                 120                 125             


Gly Val Gly Arg Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu 
    130                 135                 140                 


Arg Lys Lys Asp Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met 
145                 150                 155                 160 


Pro Gly Arg Met 
                


<210>  5460
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL36G__Homo_sapiens__NP_062564

<400>  5460

Met Arg Gly Thr Pro Gly Asp Ala Asp Gly Gly Gly Arg Ala Val Tyr 
1               5                   10                  15      


Gln Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln 
            20                  25                  30          


Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser 
        35                  40                  45              


Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro 
    50                  55                  60                  


Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln 
65                  70                  75                  80  


Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr 
                85                  90                  95      


Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu 
            100                 105                 110         


Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser 
        115                 120                 125             


Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys 
    130                 135                 140                 


Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn 
145                 150                 155                 160 


Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 


<210>  5461
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL36RN__Homo_sapiens__NP_775262

<400>  5461

Met Val Leu Ser Gly Ala Leu Cys Phe Arg Met Lys Asp Ser Ala Leu 
1               5                   10                  15      


Lys Val Leu Tyr Leu His Asn Asn Gln Leu Leu Ala Gly Gly Leu His 
            20                  25                  30          


Ala Gly Lys Val Ile Lys Gly Glu Glu Ile Ser Val Val Pro Asn Arg 
        35                  40                  45              


Trp Leu Asp Ala Ser Leu Ser Pro Val Ile Leu Gly Val Gln Gly Gly 
    50                  55                  60                  


Ser Gln Cys Leu Ser Cys Gly Val Gly Gln Glu Pro Thr Leu Thr Leu 
65                  70                  75                  80  


Glu Pro Val Asn Ile Met Glu Leu Tyr Leu Gly Ala Lys Glu Ser Lys 
                85                  90                  95      


Ser Phe Thr Phe Tyr Arg Arg Asp Met Gly Leu Thr Ser Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Tyr Pro Gly Trp Phe Leu Cys Thr Val Pro Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Arg Leu Thr Gln Leu Pro Glu Asn Gly Gly Trp Asn Ala 
    130                 135                 140                 


Pro Ile Thr Asp Phe Tyr Phe Gln Gln Cys Asp 
145                 150                 155 


<210>  5462
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL37__Homo_sapiens__NP_055254

<400>  5462

Met Ser Phe Val Gly Glu Asn Ser Gly Val Lys Met Gly Ser Glu Asp 
1               5                   10                  15      


Trp Glu Lys Asp Glu Pro Gln Cys Cys Leu Glu Asp Pro Ala Gly Ser 
            20                  25                  30          


Pro Leu Glu Pro Gly Pro Ser Leu Pro Thr Met Asn Phe Val His Thr 
        35                  40                  45              


Ser Pro Lys Val Lys Asn Leu Asn Pro Lys Lys Phe Ser Ile His Asp 
    50                  55                  60                  


Gln Asp His Lys Val Leu Val Leu Asp Ser Gly Asn Leu Ile Ala Val 
65                  70                  75                  80  


Pro Asp Lys Asn Tyr Ile Arg Pro Glu Ile Phe Phe Ala Leu Ala Ser 
                85                  90                  95      


Ser Leu Ser Ser Ala Ser Ala Glu Lys Gly Ser Pro Ile Leu Leu Gly 
            100                 105                 110         


Val Ser Lys Gly Glu Phe Cys Leu Tyr Cys Asp Lys Asp Lys Gly Gln 
        115                 120                 125             


Ser His Pro Ser Leu Gln Leu Lys Lys Glu Lys Leu Met Lys Leu Ala 
    130                 135                 140                 


Ala Gln Lys Glu Ser Ala Arg Arg Pro Phe Ile Phe Tyr Arg Ala Gln 
145                 150                 155                 160 


Val Gly Ser Trp Asn Met Leu Glu Ser Ala Ala His Pro Gly Trp Phe 
                165                 170                 175     


Ile Cys Thr Ser Cys Asn Cys Asn Glu Pro Val Gly Val Thr Asp Lys 
            180                 185                 190         


Phe Glu Asn Arg Lys His Ile Glu Phe Ser Phe Gln Pro Val Cys Lys 
        195                 200                 205             


Ala Glu Met Ser Pro Ser Glu Val Ser Asp 
    210                 215             


<210>  5463
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL3__Homo_sapiens__NP_000579

<400>  5463

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  5464
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL3RA__Homo_sapiens__NP_001254642

<400>  5464

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Gly Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            20                  25                  30          


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        35                  40                  45              


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    50                  55                  60                  


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
65                  70                  75                  80  


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                85                  90                  95      


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            100                 105                 110         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        115                 120                 125             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    130                 135                 140                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
145                 150                 155                 160 


Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val 
                165                 170                 175     


Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val 
            180                 185                 190         


Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser 
        195                 200                 205             


Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg 
    210                 215                 220                 


Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu 
225                 230                 235                 240 


Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu 
                245                 250                 255     


Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln 
            260                 265                 270         


Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu 
        275                 280                 285             


Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
    290                 295                 300 


<210>  5465
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL4__Homo_sapiens__NP_000580

<400>  5465

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  5466
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL4I1__Homo_sapiens__NP_001244947

<400>  5466

Met Pro Asn Asp Asp Phe Cys Pro Gly Leu Thr Ile Lys Ala Met Gly 
1               5                   10                  15      


Ala Glu Arg Ala Pro Gln Arg Gln Pro Cys Thr Leu His Leu Leu Val 
            20                  25                  30          


Leu Val Pro Ile Leu Leu Ser Leu Val Ala Ser Gln Asp Trp Lys Ala 
        35                  40                  45              


Glu Arg Ser Gln Asp Pro Phe Glu Lys Cys Met Gln Asp Pro Asp Tyr 
    50                  55                  60                  


Glu Gln Leu Leu Lys Val Val Thr Trp Gly Leu Asn Arg Thr Leu Lys 
65                  70                  75                  80  


Pro Gln Arg Val Ile Val Val Gly Ala Gly Val Ala Gly Leu Val Ala 
                85                  90                  95      


Ala Lys Val Leu Ser Asp Ala Gly His Lys Val Thr Ile Leu Glu Ala 
            100                 105                 110         


Asp Asn Arg Ile Gly Gly Arg Ile Phe Thr Tyr Arg Asp Gln Asn Thr 
        115                 120                 125             


Gly Trp Ile Gly Glu Leu Gly Ala Met Arg Met Pro Ser Ser His Arg 
    130                 135                 140                 


Ile Leu His Lys Leu Cys Gln Gly Leu Gly Leu Asn Leu Thr Lys Phe 
145                 150                 155                 160 


Thr Gln Tyr Asp Lys Asn Thr Trp Thr Glu Val His Glu Val Lys Leu 
                165                 170                 175     


Arg Asn Tyr Val Val Glu Lys Val Pro Glu Lys Leu Gly Tyr Ala Leu 
            180                 185                 190         


Arg Pro Gln Glu Lys Gly His Ser Pro Glu Asp Ile Tyr Gln Met Ala 
        195                 200                 205             


Leu Asn Gln Ala Leu Lys Asp Leu Lys Ala Leu Gly Cys Arg Lys Ala 
    210                 215                 220                 


Met Lys Lys Phe Glu Arg His Thr Leu Leu Glu Tyr Leu Leu Gly Glu 
225                 230                 235                 240 


Gly Asn Leu Ser Arg Pro Ala Val Gln Leu Leu Gly Asp Val Met Ser 
                245                 250                 255     


Glu Asp Gly Phe Phe Tyr Leu Ser Phe Ala Glu Ala Leu Arg Ala His 
            260                 265                 270         


Ser Cys Leu Ser Asp Arg Leu Gln Tyr Ser Arg Ile Val Gly Gly Trp 
        275                 280                 285             


Asp Leu Leu Pro Arg Ala Leu Leu Ser Ser Leu Ser Gly Leu Val Leu 
    290                 295                 300                 


Leu Asn Ala Pro Val Val Ala Met Thr Gln Gly Pro His Asp Val His 
305                 310                 315                 320 


Val Gln Ile Glu Thr Ser Pro Pro Ala Arg Asn Leu Lys Val Leu Lys 
                325                 330                 335     


Ala Asp Val Val Leu Leu Thr Ala Ser Gly Pro Ala Val Lys Arg Ile 
            340                 345                 350         


Thr Phe Ser Pro Pro Leu Pro Arg His Met Gln Glu Ala Leu Arg Arg 
        355                 360                 365             


Leu His Tyr Val Pro Ala Thr Lys Val Phe Leu Ser Phe Arg Arg Pro 
    370                 375                 380                 


Phe Trp Arg Glu Glu His Ile Glu Gly Gly His Ser Asn Thr Asp Arg 
385                 390                 395                 400 


Pro Ser Arg Met Ile Phe Tyr Pro Pro Pro Arg Glu Gly Ala Leu Leu 
                405                 410                 415     


Leu Ala Ser Tyr Thr Trp Ser Asp Ala Ala Ala Ala Phe Ala Gly Leu 
            420                 425                 430         


Ser Arg Glu Glu Ala Leu Arg Leu Ala Leu Asp Asp Val Ala Ala Leu 
        435                 440                 445             


His Gly Pro Val Val Arg Gln Leu Trp Asp Gly Thr Gly Val Val Lys 
    450                 455                 460                 


Arg Trp Ala Glu Asp Gln His Ser Gln Gly Gly Phe Val Val Gln Pro 
465                 470                 475                 480 


Pro Ala Leu Trp Gln Thr Glu Lys Asp Asp Trp Thr Val Pro Tyr Gly 
                485                 490                 495     


Arg Ile Tyr Phe Ala Gly Glu His Thr Ala Tyr Pro His Gly Trp Val 
            500                 505                 510         


Glu Thr Ala Val Lys Ser Ala Leu Arg Ala Ala Ile Lys Ile Asn Ser 
        515                 520                 525             


Arg Lys Gly Pro Ala Ser Asp Thr Ala Ser Pro Glu Gly His Ala Ser 
    530                 535                 540                 


Asp Met Glu Gly Gln Gly His Val His Gly Val Ala Ser Ser Pro Ser 
545                 550                 555                 560 


His Asp Leu Ala Lys Glu Glu Gly Ser His Pro Pro Val Gln Gly Gln 
                565                 570                 575     


Leu Ser Leu Gln Asn Thr Thr His Thr Arg Thr Ser His 
            580                 585                 


<210>  5467
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL4R__Homo_sapiens__NP_001244336

<400>  5467

Met Gln Lys Asp Ala Arg Arg Glu Gly Asn Met Lys Val Leu Gln Glu 
1               5                   10                  15      


Pro Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys 
            20                  25                  30          


Met Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln 
        35                  40                  45              


Leu Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn 
    50                  55                  60                  


Gly Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser 
65                  70                  75                  80  


Ala Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp 
                85                  90                  95      


Lys Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly 
            100                 105                 110         


Asn Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp 
        115                 120                 125             


Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr 
    130                 135                 140                 


Ala Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr 
145                 150                 155                 160 


Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu 
                165                 170                 175     


Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys 
            180                 185                 190         


Tyr Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn 
        195                 200                 205             


Ser Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val 
    210                 215                 220                 


Ser Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile 
225                 230                 235                 240 


Thr Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg 
                245                 250                 255     


Ser Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp 
            260                 265                 270         


Glu Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys 
        275                 280                 285             


Asn Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys 
    290                 295                 300                 


Arg Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly 
305                 310                 315                 320 


Ser Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu 
                325                 330                 335     


Trp Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala 
            340                 345                 350         


Pro Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser 
        355                 360                 365             


Phe Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg 
    370                 375                 380                 


Glu Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu 
385                 390                 395                 400 


Gly Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys 
                405                 410                 415     


Leu Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu 
            420                 425                 430         


Phe Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln 
        435                 440                 445             


Pro Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro 
    450                 455                 460                 


Asp Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro 
465                 470                 475                 480 


Ala Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg 
                485                 490                 495     


Glu Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu 
            500                 505                 510         


Pro Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro 
        515                 520                 525             


Gln Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu 
    530                 535                 540                 


Gln His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr 
545                 550                 555                 560 


Gln Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala 
                565                 570                 575     


Val Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser 
            580                 585                 590         


Ser Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly 
        595                 600                 605             


Ala Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro 
    610                 615                 620                 


Gly Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe 
625                 630                 635                 640 


Gly Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro 
                645                 650                 655     


Ser Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu 
            660                 665                 670         


Asp Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu 
        675                 680                 685             


Val Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His 
    690                 695                 700                 


Leu Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln 
705                 710                 715                 720 


Thr Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg 
                725                 730                 735     


Ser Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly 
            740                 745                 750         


Gly Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser 
        755                 760                 765             


Gly Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro 
    770                 775                 780                 


Gly Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val 
785                 790                 795                 800 


Ser Val Gly Pro Thr Tyr Met Arg Val Ser 
                805                 810 


<210>  5468
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL5__Homo_sapiens__XP_006714664

<400>  5468

Met Gly Val Val Val Gly Trp Ile Gly Asp Pro Gly Ser Gly Thr Asp 
1               5                   10                  15      


Asn Lys Leu Thr Gly Asp Ala Val Leu Tyr Tyr Ala Leu Ser Leu Pro 
            20                  25                  30          


Lys Ala Asn Ala Glu Arg Phe Arg Ala Met Arg Met Leu Leu His Leu 
        35                  40                  45              


Ser Leu Leu Ala Leu Gly Ala Ala Tyr Val Tyr Ala Ile Pro Thr Glu 
    50                  55                  60                  


Ile Pro Thr Ser Ala Leu Val Lys Glu Thr Leu Ala Leu Leu Ser Thr 
65                  70                  75                  80  


His Arg Thr Leu Leu Ile Ala Asn Glu Thr Leu Arg Ile Pro Val Pro 
                85                  90                  95      


Val His Lys Asn His Gln Leu Cys Thr Glu Glu Ile Phe Gln Gly Ile 
            100                 105                 110         


Gly Thr Leu Glu Ser Gln Thr Val Gln Gly Gly Thr Val Glu Arg Leu 
        115                 120                 125             


Phe Lys Asn Leu Ser Leu Ile Lys Lys Tyr Ile Asp Gly Gln Lys Lys 
    130                 135                 140                 


Lys Cys Gly Glu Glu Arg Arg Arg Val Asn Gln Phe Leu Asp Tyr Leu 
145                 150                 155                 160 


Gln Glu Phe Leu Gly Val Met Asn Thr Glu Trp Ile Ile Glu Ser 
                165                 170                 175 


<210>  5469
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL5RA__Homo_sapiens__NP_000555

<400>  5469

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  5470
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL6__Homo_sapiens__NP_000591

<400>  5470

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  5471
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL6R__Homo_sapiens__NP_000556

<400>  5471

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  5472
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL6ST__Homo_sapiens__NP_001177910

<400>  5472

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu 
            420                 425                 430         


Ile Thr Val Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser 
        435                 440                 445             


Ile Lys Ala Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val 
    450                 455                 460                 


Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln 
465                 470                 475                 480 


Leu Pro Val Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe 
                485                 490                 495     


Tyr Arg Thr Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser 
            500                 505                 510         


His Thr Glu Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met 
        515                 520                 525             


Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu 
    530                 535                 540                 


Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile 
545                 550                 555                 560 


Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val 
                565                 570                 575     


Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro 
            580                 585                 590         


Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His 
        595                 600                 605             


Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp 
    610                 615                 620                 


Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys 
625                 630                 635                 640 


Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu 
                645                 650                 655     


Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys 
            660                 665                 670         


Met Ser Ser Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser 
        675                 680                 685             


Ser Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser 
    690                 695                 700                 


Gly Tyr Arg His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu 
705                 710                 715                 720 


Ser Thr Gln Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln 
                725                 730                 735     


Leu Val Asp His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln 
            740                 745                 750         


Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser 
        755                 760                 765             


His Phe Glu Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe 
    770                 775                 780                 


Val Arg Leu Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly 
785                 790                 795                 800 


Ser Gly Gln Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe 
                805                 810                 815     


Gly Pro Gly Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met 
            820                 825                 830         


Glu Ala Ala Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr 
        835                 840                 845             


Val Arg Gln Gly Gly Tyr Met Pro Gln 
    850                 855         


<210>  5473
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7__Homo_sapiens__NP_001186815

<400>  5473

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg 
65                  70                  75                  80  


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
                85                  90                  95      


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
            100                 105                 110         


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
        115                 120                 125             


Gly Thr Lys Glu His 
    130             


<210>  5474
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R__Homo_sapiens__NP_002176

<400>  5474

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  5475
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL9__Homo_sapiens__NP_000581

<400>  5475

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


<210>  5476
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL9R__Homo_sapiens__NP_002177

<400>  5476

Met Gly Leu Gly Arg Cys Ile Trp Glu Gly Trp Thr Leu Glu Ser Glu 
1               5                   10                  15      


Ala Leu Arg Arg Asp Met Gly Thr Trp Leu Leu Ala Cys Ile Cys Ile 
            20                  25                  30          


Cys Thr Cys Val Cys Leu Gly Val Ser Val Thr Gly Glu Gly Gln Gly 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Thr Cys Leu Thr Asn Asn Ile Leu Arg Ile 
    50                  55                  60                  


Asp Cys His Trp Ser Ala Pro Glu Leu Gly Gln Gly Ser Ser Pro Trp 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Gln Ala Pro Gly Gly Thr His Lys Cys Ile 
                85                  90                  95      


Leu Arg Gly Ser Glu Cys Thr Val Val Leu Pro Pro Glu Ala Val Leu 
            100                 105                 110         


Val Pro Ser Asp Asn Phe Thr Ile Thr Phe His His Cys Met Ser Gly 
        115                 120                 125             


Arg Glu Gln Val Ser Leu Val Asp Pro Glu Tyr Leu Pro Arg Arg His 
    130                 135                 140                 


Val Lys Leu Asp Pro Pro Ser Asp Leu Gln Ser Asn Ile Ser Ser Gly 
145                 150                 155                 160 


His Cys Ile Leu Thr Trp Ser Ile Ser Pro Ala Leu Glu Pro Met Thr 
                165                 170                 175     


Thr Leu Leu Ser Tyr Glu Leu Ala Phe Lys Lys Gln Glu Glu Ala Trp 
            180                 185                 190         


Glu Gln Ala Gln His Arg Asp His Ile Val Gly Val Thr Trp Leu Ile 
        195                 200                 205             


Leu Glu Ala Phe Glu Leu Asp Pro Gly Phe Ile His Glu Ala Arg Leu 
    210                 215                 220                 


Arg Val Gln Met Ala Thr Leu Glu Asp Asp Val Val Glu Glu Glu Arg 
225                 230                 235                 240 


Tyr Thr Gly Gln Trp Ser Glu Trp Ser Gln Pro Val Cys Phe Gln Ala 
                245                 250                 255     


Pro Gln Arg Gln Gly Pro Leu Ile Pro Pro Trp Gly Trp Pro Gly Asn 
            260                 265                 270         


Thr Leu Val Ala Val Ser Ile Phe Leu Leu Leu Thr Gly Pro Thr Tyr 
        275                 280                 285             


Leu Leu Phe Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn 
    290                 295                 300                 


Val Pro Ser Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn 
305                 310                 315                 320 


Gly Asn Phe Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu 
                325                 330                 335     


Ser Gln Asp Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val 
            340                 345                 350         


Gln Glu Ala Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys 
        355                 360                 365             


Ser Val Ala Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro 
    370                 375                 380                 


Gly Asn Leu Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp 
385                 390                 395                 400 


Arg Val Gln Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr 
                405                 410                 415     


Ser Leu Thr Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys 
        435                 440                 445             


Tyr Gly Gly Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser 
    450                 455                 460                 


Gly Pro Ile Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly 
465                 470                 475                 480 


Leu Glu Thr Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln 
                485                 490                 495     


Arg Pro Gly Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val 
            500                 505                 510         


Leu Ser Lys Ala Arg Ser Trp Thr Phe 
        515                 520     


<210>  5477
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ILDR1__Homo_sapiens__NP_001186728

<400>  5477

Met Ala Trp Pro Lys Leu Pro Ala Pro Trp Leu Leu Leu Cys Thr Trp 
1               5                   10                  15      


Leu Pro Ala Gly Cys Leu Ser Leu Leu Val Thr Val Gln His Thr Glu 
            20                  25                  30          


Arg Tyr Val Thr Leu Phe Ala Ser Ile Ile Leu Lys Cys Asp Tyr Thr 
        35                  40                  45              


Thr Ser Ala Gln Leu Gln Asp Val Val Val Thr Trp Arg Phe Lys Ser 
    50                  55                  60                  


Phe Cys Lys Asp Pro Ile Phe Asp Tyr Tyr Ser Ala Ser Tyr Gln Ala 
65                  70                  75                  80  


Ala Leu Ser Leu Gly Gln Asp Pro Ser Asn Asp Cys Asn Asp Asn Gln 
                85                  90                  95      


Arg Glu Val Arg Ile Val Ala Gln Arg Arg Gly Gln Asn Glu Pro Val 
            100                 105                 110         


Leu Gly Val Asp Tyr Arg Gln Arg Lys Ile Thr Ile Gln Asn Arg Ala 
        115                 120                 125             


Asp Leu Val Ile Asn Glu Val Met Trp Trp Asp His Gly Val Tyr Tyr 
    130                 135                 140                 


Cys Thr Ile Glu Ala Pro Gly Asp Thr Ser Gly Asp Pro Asp Lys Glu 
145                 150                 155                 160 


Val Lys Leu Ile Val Leu His Trp Leu Thr Val Ile Phe Ile Ile Leu 
                165                 170                 175     


Gly Ala Leu Leu Leu Leu Leu Leu Ile Gly Val Cys Trp Cys Gln Cys 
            180                 185                 190         


Cys Pro Gln Tyr Cys Cys Cys Tyr Ile Arg Cys Pro Cys Cys Pro Ala 
        195                 200                 205             


His Cys Cys Cys Pro Glu Glu Ala Leu Ala Arg His Arg Tyr Met Lys 
    210                 215                 220                 


Gln Ala Gln Ala Leu Gly Pro Gln Met Met Gly Lys Pro Leu Tyr Trp 
225                 230                 235                 240 


Gly Ala Asp Arg Ser Ser Gln Val Ser Ser Tyr Pro Met His Pro Leu 
                245                 250                 255     


Leu Gln Arg Asp Leu Ser Leu Pro Ser Ser Leu Pro Gln Met Pro Met 
            260                 265                 270         


Thr Gln Thr Thr Asn Gln Pro Pro Ile Ala Asn Gly Val Leu Glu Tyr 
        275                 280                 285             


Leu Glu Lys Glu Leu Arg Asn Leu Asn Leu Ala Gln Pro Leu Pro Pro 
    290                 295                 300                 


Asp Leu Lys Gly Arg Phe Gly His Pro Cys Ser Met Leu Ser Ser Leu 
305                 310                 315                 320 


Gly Ser Glu Val Val Glu Arg Arg Ile Ile His Leu Pro Pro Leu Ile 
                325                 330                 335     


Arg Asp Leu Ser Ser Ser Arg Arg Thr Ser Asp Ser Leu His Gln Gln 
            340                 345                 350         


Trp Leu Thr Pro Ile Pro Ser Arg Pro Trp Asp Leu Arg Glu Gly Arg 
        355                 360                 365             


Ser His His His Tyr Pro Asp Phe His Gln Glu Leu Gln Asp Arg Gly 
    370                 375                 380                 


Pro Lys Ser Trp Ala Leu Glu Arg Arg Glu Leu Asp Pro Ser Trp Ser 
385                 390                 395                 400 


Gly Arg His Arg Ser Ser Arg Leu Asn Gly Ser Pro Ile His Trp Ser 
                405                 410                 415     


Asp Arg Asp Ser Leu Ser Asp Val Pro Ser Ser Ser Glu Ala Arg Trp 
            420                 425                 430         


Arg Pro Ser His Pro Pro Phe Arg Ser Arg Cys Gln Glu Arg Pro Arg 
        435                 440                 445             


Arg Pro Ser Pro Arg Glu Ser Thr Gln Arg His Gly Arg Arg Arg Arg 
    450                 455                 460                 


His Arg Ser Tyr Ser Pro Pro Leu Pro Ser Gly Leu Ser Ser Trp Ser 
465                 470                 475                 480 


Ser Glu Glu Asp Lys Glu Arg Gln Pro Gln Ser Trp Arg Ala His Arg 
                485                 490                 495     


Arg Gly Ser His Ser Pro His Trp Pro Glu Glu Lys Pro Pro Ser Tyr 
            500                 505                 510         


Arg Ser Leu Asp Ile Thr Pro Gly Lys Asn Ser Arg Lys Lys Gly Ser 
        515                 520                 525             


Val Glu Arg Arg Ser Glu Lys Asp Ser Ser His Ser Gly Arg Ser Val 
    530                 535                 540                 


Val Ile 
545     


<210>  5478
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ILDR2__Homo_sapiens__NP_955383

<400>  5478

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Gly Arg Thr Gly Leu Leu Ala Asp Leu Leu 
                165                 170                 175     


Pro Ser Phe Ala Val Glu Ile Met Pro Glu Trp Val Phe Val Gly Leu 
            180                 185                 190         


Val Leu Leu Gly Val Phe Leu Phe Phe Val Leu Val Gly Ile Cys Trp 
        195                 200                 205             


Cys Gln Cys Cys Pro His Ser Cys Cys Cys Tyr Val Arg Cys Pro Cys 
    210                 215                 220                 


Cys Pro Asp Ser Cys Cys Cys Pro Gln Ala Leu Tyr Glu Ala Gly Lys 
225                 230                 235                 240 


Ala Ala Lys Ala Gly Tyr Pro Pro Ser Val Ser Gly Val Pro Gly Pro 
                245                 250                 255     


Tyr Ser Ile Pro Ser Val Pro Leu Gly Gly Ala Pro Ser Ser Gly Met 
            260                 265                 270         


Leu Met Asp Lys Pro His Pro Pro Pro Leu Ala Pro Ser Asp Ser Thr 
        275                 280                 285             


Gly Gly Ser His Ser Val Arg Lys Gly Tyr Arg Ile Gln Ala Asp Lys 
    290                 295                 300                 


Glu Arg Asp Ser Met Lys Val Leu Tyr Tyr Val Glu Lys Glu Leu Ala 
305                 310                 315                 320 


Gln Phe Asp Pro Ala Arg Arg Met Arg Gly Arg Tyr Asn Asn Thr Ile 
                325                 330                 335     


Ser Glu Leu Ser Ser Leu His Glu Glu Asp Ser Asn Phe Arg Gln Ser 
            340                 345                 350         


Phe His Gln Met Arg Ser Lys Gln Phe Pro Val Ser Gly Asp Leu Glu 
        355                 360                 365             


Ser Asn Pro Asp Tyr Trp Ser Gly Val Met Gly Gly Ser Ser Gly Ala 
    370                 375                 380                 


Ser Arg Gly Pro Ser Ala Met Glu Tyr Asn Lys Glu Asp Arg Glu Ser 
385                 390                 395                 400 


Phe Arg His Ser Gln Pro Arg Ser Lys Ser Glu Met Leu Ser Arg Lys 
                405                 410                 415     


Asn Phe Ala Thr Gly Val Pro Ala Val Ser Met Asp Glu Leu Ala Ala 
            420                 425                 430         


Phe Ala Asp Ser Tyr Gly Gln Arg Pro Arg Arg Ala Asp Gly Asn Ser 
        435                 440                 445             


His Glu Ala Arg Gly Gly Ser Arg Phe Glu Arg Ser Glu Ser Arg Ala 
    450                 455                 460                 


His Ser Gly Phe Tyr Gln Asp Asp Ser Leu Glu Glu Tyr Tyr Gly Gln 
465                 470                 475                 480 


Arg Ser Arg Ser Arg Glu Pro Leu Thr Asp Ala Asp Arg Gly Trp Ala 
                485                 490                 495     


Phe Ser Pro Ala Arg Arg Arg Pro Ala Glu Asp Ala His Leu Pro Arg 
            500                 505                 510         


Leu Val Ser Arg Thr Pro Gly Thr Ala Pro Lys Tyr Asp His Ser Tyr 
        515                 520                 525             


Leu Gly Ser Ala Arg Glu Arg Gln Ala Arg Pro Glu Gly Ala Ser Arg 
    530                 535                 540                 


Gly Gly Ser Leu Glu Thr Pro Ser Lys Arg Ser Ala Gln Leu Gly Pro 
545                 550                 555                 560 


Arg Ser Ala Ser Tyr Tyr Ala Trp Ser Pro Pro Gly Thr Tyr Lys Ala 
                565                 570                 575     


Gly Ser Ser Gln Asp Asp Gln Glu Asp Ala Ser Asp Asp Ala Leu Pro 
            580                 585                 590         


Pro Tyr Ser Glu Leu Glu Leu Thr Arg Gly Pro Ser Tyr Arg Gly Arg 
        595                 600                 605             


Asp Leu Pro Tyr His Ser Asn Ser Glu Lys Lys Arg Lys Lys Glu Pro 
    610                 615                 620                 


Ala Lys Lys Thr Asn Asp Phe Pro Thr Arg Met Ser Leu Val Val 
625                 630                 635                 


<210>  5479
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ILF2__Homo_sapiens__NP_001254738

<400>  5479

Met Ala Phe Pro Arg Val Lys Pro Ala Pro Asp Glu Thr Ser Phe Ser 
1               5                   10                  15      


Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu Ala Pro Asn Ser Ala Glu 
            20                  25                  30          


Gln Ala Ser Ile Leu Ser Leu Val Thr Lys Ile Asn Asn Val Ile Asp 
        35                  40                  45              


Asn Leu Ile Val Ala Pro Gly Thr Phe Glu Val Gln Ile Glu Glu Val 
    50                  55                  60                  


Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr Met Thr Thr Gly His Asn 
65                  70                  75                  80  


Val Ala Asp Leu Val Val Ile Leu Lys Ile Leu Pro Thr Leu Glu Ala 
                85                  90                  95      


Val Ala Ala Leu Gly Asn Lys Val Val Glu Ser Leu Arg Ala Gln Asp 
            100                 105                 110         


Pro Ser Glu Val Leu Thr Met Leu Thr Asn Glu Thr Gly Phe Glu Ile 
        115                 120                 125             


Ser Ser Ser Asp Ala Thr Val Lys Ile Leu Ile Thr Thr Val Pro Pro 
    130                 135                 140                 


Asn Leu Arg Lys Leu Asp Pro Glu Leu His Leu Asp Ile Lys Val Leu 
145                 150                 155                 160 


Gln Ser Ala Leu Ala Ala Ile Arg His Ala Arg Trp Phe Glu Glu Asn 
                165                 170                 175     


Ala Ser Gln Ser Thr Val Lys Val Leu Ile Arg Leu Leu Lys Asp Leu 
            180                 185                 190         


Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu Thr Pro Trp Ile Leu Asp 
        195                 200                 205             


Leu Leu Gly His Tyr Ala Val Met Asn Asn Pro Thr Arg Gln Pro Leu 
    210                 215                 220                 


Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu Gln Ile Leu Ala Ala Gly 
225                 230                 235                 240 


Leu Phe Leu Pro Gly Ser Val Gly Ile Thr Asp Pro Cys Glu Ser Gly 
                245                 250                 255     


Asn Phe Arg Val His Thr Val Met Thr Leu Glu Gln Gln Asp Met Val 
            260                 265                 270         


Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile Leu Ser His Gly Gly Phe 
        275                 280                 285             


Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala Ser Tyr Leu Ala Ser Glu 
    290                 295                 300                 


Ile Ser Thr Trp Asp Gly Val Ile Val Thr Pro Ser Glu Lys Ala Tyr 
305                 310                 315                 320 


Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu Glu Glu Glu Glu Asn Thr 
                325                 330                 335     


Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu Ser Met Glu Thr Gln Glu 
            340                 345                 350         


<210>  5480
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ILF3__Homo_sapiens__NP_001131145

<400>  5480

Met Arg Pro Met Arg Ile Phe Val Asn Asp Asp Arg His Val Met Ala 
1               5                   10                  15      


Lys His Ser Ser Val Tyr Pro Thr Gln Glu Glu Leu Glu Ala Val Gln 
            20                  25                  30          


Asn Met Val Ser His Thr Glu Arg Ala Leu Lys Ala Val Ser Asp Trp 
        35                  40                  45              


Ile Asp Glu Gln Glu Lys Gly Ser Ser Glu Gln Ala Glu Ser Asp Asn 
    50                  55                  60                  


Met Asp Val Pro Pro Glu Asp Asp Ser Lys Glu Gly Ala Gly Glu Gln 
65                  70                  75                  80  


Lys Thr Glu His Met Thr Arg Thr Leu Arg Gly Val Met Arg Val Gly 
                85                  90                  95      


Leu Val Ala Lys Gly Leu Leu Leu Lys Gly Asp Leu Asp Leu Glu Leu 
            100                 105                 110         


Val Leu Leu Cys Lys Glu Lys Pro Thr Thr Ala Leu Leu Asp Lys Val 
        115                 120                 125             


Ala Asp Asn Leu Ala Ile Gln Leu Ala Ala Val Thr Glu Asp Lys Tyr 
    130                 135                 140                 


Glu Ile Leu Gln Ser Val Asp Asp Ala Ala Ile Val Ile Lys Asn Thr 
145                 150                 155                 160 


Lys Glu Pro Pro Leu Ser Leu Thr Ile His Leu Thr Ser Pro Val Val 
                165                 170                 175     


Arg Glu Glu Met Glu Lys Val Leu Ala Gly Glu Thr Leu Ser Val Asn 
            180                 185                 190         


Asp Pro Pro Asp Val Leu Asp Arg Gln Lys Cys Leu Ala Ala Leu Ala 
        195                 200                 205             


Ser Leu Arg His Ala Lys Trp Phe Gln Ala Arg Ala Asn Gly Leu Lys 
    210                 215                 220                 


Ser Cys Val Ile Val Ile Arg Val Leu Arg Asp Leu Cys Thr Arg Val 
225                 230                 235                 240 


Pro Thr Trp Gly Pro Leu Arg Gly Trp Pro Leu Glu Leu Leu Cys Glu 
                245                 250                 255     


Lys Ser Ile Gly Thr Ala Asn Arg Pro Met Gly Ala Gly Glu Ala Leu 
            260                 265                 270         


Arg Arg Val Leu Glu Cys Leu Ala Ser Gly Ile Val Met Pro Asp Gly 
        275                 280                 285             


Ser Gly Ile Tyr Asp Pro Cys Glu Lys Glu Ala Thr Asp Ala Ile Gly 
    290                 295                 300                 


His Leu Asp Arg Gln Gln Arg Glu Asp Ile Thr Gln Ser Ala Gln His 
305                 310                 315                 320 


Ala Leu Arg Leu Ala Ala Phe Gly Gln Leu His Lys Val Leu Gly Met 
                325                 330                 335     


Asp Pro Leu Pro Ser Lys Met Pro Lys Lys Pro Lys Asn Glu Asn Pro 
            340                 345                 350         


Val Asp Tyr Thr Val Gln Ile Pro Pro Ser Thr Thr Tyr Ala Ile Thr 
        355                 360                 365             


Pro Met Lys Arg Pro Met Glu Glu Asp Gly Glu Glu Lys Ser Pro Ser 
    370                 375                 380                 


Lys Lys Lys Lys Lys Ile Gln Lys Lys Glu Glu Lys Ala Glu Pro Pro 
385                 390                 395                 400 


Gln Ala Met Asn Ala Leu Met Arg Leu Asn Gln Leu Lys Pro Gly Leu 
                405                 410                 415     


Gln Tyr Lys Leu Val Ser Gln Thr Gly Pro Val His Ala Pro Ile Phe 
            420                 425                 430         


Thr Met Ser Val Glu Val Asp Gly Asn Ser Phe Glu Ala Ser Gly Pro 
        435                 440                 445             


Ser Lys Lys Thr Ala Lys Leu His Val Ala Val Lys Val Leu Gln Asp 
    450                 455                 460                 


Met Gly Leu Pro Thr Gly Ala Glu Gly Arg Asp Ser Ser Lys Gly Glu 
465                 470                 475                 480 


Asp Ser Ala Glu Glu Thr Glu Ala Lys Pro Ala Val Val Ala Pro Ala 
                485                 490                 495     


Pro Val Val Glu Ala Val Ser Thr Pro Ser Ala Ala Phe Pro Ser Asp 
            500                 505                 510         


Ala Thr Ala Glu Asn Val Lys Gln Gln Gly Pro Ile Leu Thr Lys His 
        515                 520                 525             


Gly Lys Asn Pro Val Met Glu Leu Asn Glu Lys Arg Arg Gly Leu Lys 
    530                 535                 540                 


Tyr Glu Leu Ile Ser Glu Thr Gly Gly Ser His Asp Lys Arg Phe Val 
545                 550                 555                 560 


Met Glu Val Glu Val Asp Gly Gln Lys Phe Gln Gly Ala Gly Ser Asn 
                565                 570                 575     


Lys Lys Val Ala Lys Ala Tyr Ala Ala Leu Ala Ala Leu Glu Lys Leu 
            580                 585                 590         


Phe Pro Asp Thr Pro Leu Ala Leu Asp Ala Asn Lys Lys Lys Arg Ala 
        595                 600                 605             


Pro Val Pro Val Arg Gly Gly Pro Lys Phe Ala Ala Lys Pro His Asn 
    610                 615                 620                 


Pro Gly Phe Gly Met Gly Gly Pro Met His Asn Glu Val Pro Pro Pro 
625                 630                 635                 640 


Pro Asn Leu Arg Gly Arg Gly Arg Gly Gly Ser Ile Arg Gly Arg Gly 
                645                 650                 655     


Arg Gly Arg Gly Phe Gly Gly Ala Asn His Gly Gly Tyr Met Asn Ala 
            660                 665                 670         


Gly Ala Gly Tyr Gly Ser Tyr Gly Tyr Gly Gly Asn Ser Ala Thr Ala 
        675                 680                 685             


Gly Tyr Ser Asp Phe Phe Thr Asp Cys Tyr Gly Tyr His Asp Phe Gly 
    690                 695                 700                 


Ser Ser 
705     


<210>  5481
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ILK__Homo_sapiens__NP_001014795

<400>  5481

Met Asp Asp Ile Phe Thr Gln Cys Arg Glu Gly Asn Ala Val Ala Val 
1               5                   10                  15      


Arg Leu Trp Leu Asp Asn Thr Glu Asn Asp Leu Asn Gln Gly Asp Asp 
            20                  25                  30          


His Gly Phe Ser Pro Leu His Trp Ala Cys Arg Glu Gly Arg Ser Ala 
        35                  40                  45              


Val Val Glu Met Leu Ile Met Arg Gly Ala Arg Ile Asn Val Met Asn 
    50                  55                  60                  


Arg Gly Asp Asp Thr Pro Leu His Leu Ala Ala Ser His Gly His Arg 
65                  70                  75                  80  


Asp Ile Val Gln Lys Leu Leu Gln Tyr Lys Ala Asp Ile Asn Ala Val 
                85                  90                  95      


Asn Glu His Gly Asn Val Pro Leu His Tyr Ala Cys Phe Trp Gly Gln 
            100                 105                 110         


Asp Gln Val Ala Glu Asp Leu Val Ala Asn Gly Ala Leu Val Ser Ile 
        115                 120                 125             


Cys Asn Lys Tyr Gly Glu Met Pro Val Asp Lys Ala Lys Ala Pro Leu 
    130                 135                 140                 


Arg Glu Leu Leu Arg Glu Arg Ala Glu Lys Met Gly Gln Asn Leu Asn 
145                 150                 155                 160 


Arg Ile Pro Tyr Lys Asp Thr Phe Trp Lys Gly Thr Thr Arg Thr Arg 
                165                 170                 175     


Pro Arg Asn Gly Thr Leu Asn Lys His Ser Gly Ile Asp Phe Lys Gln 
            180                 185                 190         


Leu Asn Phe Leu Thr Lys Leu Asn Glu Asn His Ser Gly Glu Leu Trp 
        195                 200                 205             


Lys Gly Arg Trp Gln Gly Asn Asp Ile Val Val Lys Val Leu Lys Val 
    210                 215                 220                 


Arg Asp Trp Ser Thr Arg Lys Ser Arg Asp Phe Asn Glu Glu Cys Pro 
225                 230                 235                 240 


Arg Leu Arg Ile Phe Ser His Pro Asn Val Leu Pro Val Leu Gly Ala 
                245                 250                 255     


Cys Gln Ser Pro Pro Ala Pro His Pro Thr Leu Ile Thr His Trp Met 
            260                 265                 270         


Pro Tyr Gly Ser Leu Tyr Asn Val Leu His Glu Gly Thr Asn Phe Val 
        275                 280                 285             


Val Asp Gln Ser Gln Ala Val Lys Phe Ala Leu Asp Met Ala Arg Gly 
    290                 295                 300                 


Met Ala Phe Leu His Thr Leu Glu Pro Leu Ile Pro Arg His Ala Leu 
305                 310                 315                 320 


Asn Ser Arg Ser Val Met Ile Asp Glu Asp Met Thr Ala Arg Ile Ser 
                325                 330                 335     


Met Ala Asp Val Lys Phe Ser Phe Gln Cys Pro Gly Arg Met Tyr Ala 
            340                 345                 350         


Pro Ala Trp Val Ala Pro Glu Ala Leu Gln Lys Lys Pro Glu Asp Thr 
        355                 360                 365             


Asn Arg Arg Ser Ala Asp Met Trp Ser Phe Ala Val Leu Leu Trp Glu 
    370                 375                 380                 


Leu Val Thr Arg Glu Val Pro Phe Ala Asp Leu Ser Asn Met Glu Ile 
385                 390                 395                 400 


Gly Met Lys Val Ala Leu Glu Gly Leu Arg Pro Thr Ile Pro Pro Gly 
                405                 410                 415     


Ile Ser Pro His Val Cys Lys Leu Met Lys Ile Cys Met Asn Glu Asp 
            420                 425                 430         


Pro Ala Lys Arg Pro Lys Phe Asp Met Ile Val Pro Ile Leu Glu Lys 
        435                 440                 445             


Met Gln Asp Lys 
    450         


<210>  5482
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMMP1L__Homo_sapiens__NP_001291203

<400>  5482

Met Leu Arg Gly Val Leu Gly Lys Thr Phe Arg Leu Val Gly Tyr Thr 
1               5                   10                  15      


Ile Gln Tyr Gly Cys Ile Ala His Cys Ala Phe Glu Tyr Val Gly Gly 
            20                  25                  30          


Val Val Met Cys Ser Gly Pro Ser Met Glu Pro Thr Ile Gln Asn Ser 
        35                  40                  45              


Asp Ile Val Phe Ala Glu Asn Leu Ser Arg His Phe Tyr Gly Ile Gln 
    50                  55                  60                  


Arg Gly Asp Ile Val Ile Ala Lys Ser Pro Ser Asp Pro Lys Ser Asn 
65                  70                  75                  80  


Ile Cys Lys Arg Val Ile Gly Leu Glu Gly Asp Lys Ile Leu Thr Thr 
                85                  90                  95      


Ser Pro Ser Asp Phe Phe Lys Ser His Ser Tyr Val Pro Met Gly His 
            100                 105                 110         


Val Trp Leu Glu Gly Asp Asn Leu Gln Asn Ser Thr Asp Ser Arg Cys 
        115                 120                 125             


Tyr Gly Pro Ile Pro Tyr Gly Leu Ile Arg Gly Arg Ile Phe Phe Lys 
    130                 135                 140                 


Ile Trp Pro Leu Ser Asp Phe Gly Phe Leu Arg Ala Ser Pro Asn Gly 
145                 150                 155                 160 


His Arg Phe Ser Asp Asp 
                165     


<210>  5483
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMMP2L__Homo_sapiens__XP_005250687

<400>  5483

Met Ala Gln Ser Gln Gly Trp Val Lys Arg Tyr Ile Lys Ala Phe Cys 
1               5                   10                  15      


Lys Gly Phe Phe Val Ala Val Pro Val Ala Val Thr Phe Leu Asp Arg 
            20                  25                  30          


Val Ala Cys Val Ala Arg Val Glu Gly Ala Ser Met Gln Pro Ser Leu 
        35                  40                  45              


Asn Pro Gly Gly Ser Gln Ser Ser Asp Val Val Leu Leu Asn His Trp 
    50                  55                  60                  


Lys Val Arg Asn Phe Glu Val His Arg Gly Asp Ile Val Ser Leu Val 
65                  70                  75                  80  


Ser Pro Lys Asn Pro Glu Gln Lys Ile Ile Lys Arg Val Ile Ala Leu 
                85                  90                  95      


Glu Gly Asp Ile Val Arg Thr Ile Gly His Lys Asn Arg Tyr Val Lys 
            100                 105                 110         


Val Pro Arg Gly His Ile Trp Val Glu Gly Asp His His Gly His Ser 
        115                 120                 125             


Phe Asp Ser Asn Ser Phe Gly Pro Val Ser Leu Gly Leu Leu His Ala 
    130                 135                 140                 


His Ala Thr His Ile Leu Trp Pro Pro Glu Arg Trp Gln Lys Leu Glu 
145                 150                 155                 160 


Ser Val Leu Pro Pro Glu Arg Leu Pro Val Gln Arg Glu Glu Glu 
                165                 170                 175 


<210>  5484
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMMT__Homo_sapiens__NP_001093639

<400>  5484

Met Leu Arg Ala Cys Gln Leu Ser Gly Val Thr Ala Ala Ala Gln Ser 
1               5                   10                  15      


Cys Leu Cys Gly Lys Phe Val Leu Arg Pro Leu Arg Pro Cys Arg Arg 
            20                  25                  30          


Tyr Ser Thr Ser Gly Ser Ser Gly Leu Thr Thr Gly Lys Ile Ala Gly 
        35                  40                  45              


Ala Gly Leu Leu Phe Val Gly Gly Gly Ile Gly Gly Thr Ile Leu Tyr 
    50                  55                  60                  


Ala Lys Trp Asp Ser His Phe Arg Glu Ser Val Glu Lys Thr Ile Pro 
65                  70                  75                  80  


Tyr Ser Asp Lys Leu Phe Glu Met Val Leu Gly Pro Ala Ala Tyr Asn 
                85                  90                  95      


Val Pro Leu Pro Lys Lys Ser Ile Gln Ser Gly Pro Leu Lys Ile Ser 
            100                 105                 110         


Ser Val Ser Glu Val Met Lys Glu Ser Lys Gln Pro Ala Ser Gln Leu 
        115                 120                 125             


Gln Lys Gln Lys Gly Asp Thr Pro Ala Ser Ala Thr Ala Pro Thr Glu 
    130                 135                 140                 


Ala Ala Gln Ile Ile Ser Ala Ala Gly Asp Thr Leu Ser Val Pro Ala 
145                 150                 155                 160 


Pro Ala Val Gln Pro Glu Glu Ser Leu Lys Thr Asp His Pro Glu Ile 
                165                 170                 175     


Gly Glu Gly Lys Pro Thr Pro Ala Leu Ser Glu Ala Ser Ser Ser Ser 
            180                 185                 190         


Ile Arg Glu Arg Pro Pro Glu Glu Val Ala Ala Arg Leu Ala Gln Gln 
        195                 200                 205             


Glu Lys Gln Glu Gln Val Lys Ile Glu Ser Leu Ala Lys Ser Leu Glu 
    210                 215                 220                 


Asp Ala Leu Arg Gln Thr Ala Ser Val Thr Leu Gln Ala Ile Ala Ala 
225                 230                 235                 240 


Gln Asn Ala Ala Val Gln Ala Val Asn Ala His Ser Asn Ile Leu Lys 
                245                 250                 255     


Ala Ala Met Asp Asn Ser Glu Ile Ala Gly Glu Lys Lys Ser Ala Gln 
            260                 265                 270         


Trp Arg Thr Val Glu Gly Ala Leu Lys Glu Arg Arg Lys Ala Val Asp 
        275                 280                 285             


Glu Ala Ala Asp Ala Leu Leu Lys Ala Lys Glu Glu Leu Glu Lys Met 
    290                 295                 300                 


Lys Ser Val Ile Glu Asn Ala Lys Lys Lys Glu Val Ala Gly Ala Lys 
305                 310                 315                 320 


Pro His Ile Thr Ala Ala Glu Gly Lys Leu His Asn Met Ile Val Asp 
                325                 330                 335     


Leu Asp Asn Val Val Lys Lys Val Gln Ala Ala Gln Ser Glu Ala Lys 
            340                 345                 350         


Val Val Ser Gln Tyr His Glu Leu Val Val Gln Ala Arg Asp Asp Phe 
        355                 360                 365             


Lys Arg Glu Leu Asp Ser Ile Thr Pro Glu Val Leu Pro Gly Trp Lys 
    370                 375                 380                 


Gly Met Ser Val Ser Asp Leu Ala Asp Lys Leu Ser Thr Asp Asp Leu 
385                 390                 395                 400 


Asn Ser Leu Ile Ala His Ala His Arg Arg Ile Asp Gln Leu Asn Arg 
                405                 410                 415     


Glu Leu Ala Glu Gln Lys Ala Thr Glu Lys Gln His Ile Thr Leu Ala 
            420                 425                 430         


Leu Glu Lys Gln Lys Leu Glu Glu Lys Arg Ala Phe Asp Ser Ala Val 
        435                 440                 445             


Ala Lys Ala Leu Glu His His Arg Ser Glu Ile Gln Ala Glu Gln Asp 
    450                 455                 460                 


Arg Lys Ile Glu Glu Val Arg Asp Ala Met Glu Asn Glu Met Arg Thr 
465                 470                 475                 480 


Gln Leu Arg Arg Gln Ala Ala Ala His Thr Asp His Leu Arg Asp Val 
                485                 490                 495     


Leu Arg Val Gln Glu Gln Glu Leu Lys Ser Glu Phe Glu Gln Asn Leu 
            500                 505                 510         


Ser Glu Lys Leu Ser Glu Gln Glu Leu Gln Phe Arg Arg Leu Ser Gln 
        515                 520                 525             


Glu Gln Val Asp Asn Phe Thr Leu Asp Ile Asn Thr Ala Tyr Ala Arg 
    530                 535                 540                 


Leu Arg Gly Ile Glu Gln Ala Val Gln Ser His Ala Val Ala Glu Glu 
545                 550                 555                 560 


Glu Ala Arg Lys Ala His Gln Leu Trp Leu Ser Val Glu Ala Leu Lys 
                565                 570                 575     


Tyr Ser Met Lys Thr Ser Ser Ala Glu Thr Pro Thr Ile Pro Leu Gly 
            580                 585                 590         


Ser Ala Val Glu Ala Ile Lys Ala Asn Cys Ser Asp Asn Glu Phe Thr 
        595                 600                 605             


Gln Ala Leu Thr Ala Ala Ile Pro Pro Glu Ser Leu Thr Arg Gly Val 
    610                 615                 620                 


Tyr Ser Glu Glu Thr Leu Arg Ala Arg Phe Tyr Ala Val Gln Lys Leu 
625                 630                 635                 640 


Ala Arg Arg Val Ala Met Ile Asp Glu Thr Arg Asn Ser Leu Tyr Gln 
                645                 650                 655     


Tyr Phe Leu Ser Tyr Leu Gln Ser Leu Leu Leu Phe Pro Pro Gln Gln 
            660                 665                 670         


Leu Lys Pro Pro Pro Glu Leu Cys Pro Glu Asp Ile Asn Thr Phe Lys 
        675                 680                 685             


Leu Leu Ser Tyr Ala Ser Tyr Cys Ile Glu His Gly Asp Leu Glu Leu 
    690                 695                 700                 


Ala Ala Lys Phe Val Asn Gln Leu Lys Gly Glu Ser Arg Arg Val Ala 
705                 710                 715                 720 


Gln Asp Trp Leu Lys Glu Ala Arg Met Thr Leu Glu Thr Lys Gln Ile 
                725                 730                 735     


Val Glu Ile Leu Thr Ala Tyr Ala Ser Ala Val Gly Ile Gly Thr Thr 
            740                 745                 750         


Gln Val Gln Pro Glu 
        755         


<210>  5485
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMP3__Homo_sapiens__NP_060755

<400>  5485

Met Val Arg Lys Leu Lys Phe His Glu Gln Lys Leu Leu Lys Gln Val 
1               5                   10                  15      


Asp Phe Leu Asn Trp Glu Val Thr Asp His Asn Leu His Glu Leu Arg 
            20                  25                  30          


Val Leu Arg Arg Tyr Arg Leu Gln Arg Arg Glu Asp Tyr Thr Arg Tyr 
        35                  40                  45              


Asn Gln Leu Ser Arg Ala Val Arg Glu Leu Ala Arg Arg Leu Arg Asp 
    50                  55                  60                  


Leu Pro Glu Arg Asp Gln Phe Arg Val Arg Ala Ser Ala Ala Leu Leu 
65                  70                  75                  80  


Asp Lys Leu Tyr Ala Leu Gly Leu Val Pro Thr Arg Gly Ser Leu Glu 
                85                  90                  95      


Leu Cys Asp Phe Val Thr Ala Ser Ser Phe Cys Arg Arg Arg Leu Pro 
            100                 105                 110         


Thr Val Leu Leu Lys Leu Arg Met Ala Gln His Leu Gln Ala Ala Val 
        115                 120                 125             


Ala Phe Val Glu Gln Gly His Val Arg Val Gly Pro Asp Val Val Thr 
    130                 135                 140                 


Asp Pro Ala Phe Leu Val Thr Arg Ser Met Glu Asp Phe Val Thr Trp 
145                 150                 155                 160 


Val Asp Ser Ser Lys Ile Lys Arg His Val Leu Glu Tyr Asn Glu Glu 
                165                 170                 175     


Arg Asp Asp Phe Asp Leu Glu Ala 
            180                 


<210>  5486
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPA1__Homo_sapiens__NP_001138350

<400>  5486

Met Gly Gln Arg Pro Gly Pro Val Leu Pro Ala Val Ala Val Leu Gly 
1               5                   10                  15      


Gln Val Ala Lys Arg Lys Val Ala Trp Leu Leu Arg Trp Lys Ala Val 
            20                  25                  30          


Thr Arg Thr Glu Thr Ala Gly Asn Ser Ser Gly Val Tyr Gly Phe Gly 
        35                  40                  45              


Lys Met Lys Ile Phe Val Lys Tyr Phe Gln Lys Met Ala Asp Pro Trp 
    50                  55                  60                  


Gln Glu Cys Met Asp Tyr Ala Val Thr Leu Ala Arg Gln Ala Gly Glu 
65                  70                  75                  80  


Val Val Cys Glu Ala Ile Lys Asn Glu Met Asn Val Met Leu Lys Ser 
                85                  90                  95      


Ser Pro Val Asp Leu Val Thr Ala Thr Asp Gln Lys Val Glu Lys Met 
            100                 105                 110         


Leu Ile Ser Ser Ile Lys Glu Lys Tyr Pro Ser His Ser Phe Ile Gly 
        115                 120                 125             


Glu Glu Ser Val Ala Ala Gly Glu Lys Ser Ile Leu Thr Asp Asn Pro 
    130                 135                 140                 


Thr Trp Ile Ile Asp Pro Ile Asp Gly Thr Thr Asn Phe Val His Arg 
145                 150                 155                 160 


Phe Pro Phe Val Ala Val Ser Ile Gly Phe Ala Val Asn Lys Lys Ile 
                165                 170                 175     


Glu Phe Gly Val Val Tyr Ser Cys Val Glu Gly Lys Met Tyr Thr Ala 
            180                 185                 190         


Arg Lys Gly Lys Gly Ala Phe Cys Asn Gly Gln Lys Leu Gln Val Ser 
        195                 200                 205             


Gln Gln Glu Asp Ile Thr Lys Ser Leu Leu Val Thr Glu Leu Gly Ser 
    210                 215                 220                 


Ser Arg Thr Pro Glu Thr Val Arg Met Val Leu Ser Asn Met Glu Lys 
225                 230                 235                 240 


Leu Phe Cys Ile Pro Val His Gly Ile Arg Ser Val Gly Thr Ala Ala 
                245                 250                 255     


Val Asn Met Cys Leu Val Ala Thr Gly Gly Ala Asp Ala Tyr Tyr Glu 
            260                 265                 270         


Met Gly Ile His Cys Trp Asp Val Ala Gly Ala Gly Ile Ile Val Thr 
        275                 280                 285             


Glu Ala Gly Gly Val Leu Met Asp Val Thr Gly Gly Pro Phe Asp Leu 
    290                 295                 300                 


Met Ser Arg Arg Val Ile Ala Ala Asn Asn Arg Ile Leu Ala Glu Arg 
305                 310                 315                 320 


Ile Ala Lys Glu Ile Gln Val Ile Pro Leu Gln Arg Asp Asp Glu Asp 
                325                 330                 335     


<210>  5487
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPA2__Homo_sapiens__NP_055029

<400>  5487

Met Lys Pro Ser Gly Glu Asp Gln Ala Ala Leu Ala Ala Gly Pro Trp 
1               5                   10                  15      


Glu Glu Cys Phe Gln Ala Ala Val Gln Leu Ala Leu Arg Ala Gly Gln 
            20                  25                  30          


Ile Ile Arg Lys Ala Leu Thr Glu Glu Lys Arg Val Ser Thr Lys Thr 
        35                  40                  45              


Ser Ala Ala Asp Leu Val Thr Glu Thr Asp His Leu Val Glu Asp Leu 
    50                  55                  60                  


Ile Ile Ser Glu Leu Arg Glu Arg Phe Pro Ser His Arg Phe Ile Ala 
65                  70                  75                  80  


Glu Glu Ala Ala Ala Ser Gly Ala Lys Cys Val Leu Thr His Ser Pro 
                85                  90                  95      


Thr Trp Ile Ile Asp Pro Ile Asp Gly Thr Cys Asn Phe Val His Arg 
            100                 105                 110         


Phe Pro Thr Val Ala Val Ser Ile Gly Phe Ala Val Arg Gln Glu Leu 
        115                 120                 125             


Glu Phe Gly Val Ile Tyr His Cys Thr Glu Glu Arg Leu Tyr Thr Gly 
    130                 135                 140                 


Arg Arg Gly Arg Gly Ala Phe Cys Asn Gly Gln Arg Leu Arg Val Ser 
145                 150                 155                 160 


Gly Glu Thr Asp Leu Ser Lys Ala Leu Val Leu Thr Glu Ile Gly Pro 
                165                 170                 175     


Lys Arg Asp Pro Ala Thr Leu Lys Leu Phe Leu Ser Asn Met Glu Arg 
            180                 185                 190         


Leu Leu His Ala Lys Ala His Gly Val Arg Val Ile Gly Ser Ser Thr 
        195                 200                 205             


Leu Ala Leu Cys His Leu Ala Ser Gly Ala Ala Asp Ala Tyr Tyr Gln 
    210                 215                 220                 


Phe Gly Leu His Cys Trp Asp Leu Ala Ala Ala Thr Val Ile Ile Arg 
225                 230                 235                 240 


Glu Ala Gly Gly Ile Val Ile Asp Thr Ser Gly Gly Pro Leu Asp Leu 
                245                 250                 255     


Met Ala Cys Arg Val Val Ala Ala Ser Thr Arg Glu Met Ala Met Leu 
            260                 265                 270         


Ile Ala Gln Ala Leu Gln Thr Ile Asn Tyr Gly Arg Asp Asp Glu Lys 
        275                 280                 285             


<210>  5488
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPACT__Homo_sapiens__NP_060909

<400>  5488

Met Ala Glu Gly Asp Ala Gly Ser Asp Gln Arg Gln Asn Glu Glu Ile 
1               5                   10                  15      


Glu Ala Met Ala Ala Ile Tyr Gly Glu Glu Trp Cys Val Ile Asp Asp 
            20                  25                  30          


Cys Ala Lys Ile Phe Cys Ile Arg Ile Ser Asp Asp Ile Asp Asp Pro 
        35                  40                  45              


Lys Trp Thr Leu Cys Leu Gln Val Met Leu Pro Asn Glu Tyr Pro Gly 
    50                  55                  60                  


Thr Ala Pro Pro Ile Tyr Gln Leu Asn Ala Pro Trp Leu Lys Gly Gln 
65                  70                  75                  80  


Glu Arg Ala Asp Leu Ser Asn Ser Leu Glu Glu Ile Tyr Ile Gln Asn 
                85                  90                  95      


Ile Gly Glu Ser Ile Leu Tyr Leu Trp Val Glu Lys Ile Arg Asp Val 
            100                 105                 110         


Leu Ile Gln Lys Ser Gln Met Thr Glu Pro Gly Pro Asp Val Lys Lys 
        115                 120                 125             


Lys Thr Glu Glu Glu Asp Val Glu Cys Glu Asp Asp Leu Ile Leu Ala 
    130                 135                 140                 


Cys Gln Pro Glu Ser Ser Val Lys Ala Leu Asp Phe Asp Ile Ser Glu 
145                 150                 155                 160 


Thr Arg Thr Glu Val Glu Val Glu Glu Leu Pro Pro Ile Asp His Gly 
                165                 170                 175     


Ile Pro Ile Thr Asp Arg Arg Ser Thr Phe Gln Ala His Leu Ala Pro 
            180                 185                 190         


Val Val Cys Pro Lys Gln Val Lys Met Val Leu Ser Lys Leu Tyr Glu 
        195                 200                 205             


Asn Lys Lys Ile Ala Ser Ala Thr His Asn Ile Tyr Ala Tyr Arg Ile 
    210                 215                 220                 


Tyr Cys Glu Asp Lys Gln Thr Phe Leu Gln Asp Cys Glu Asp Asp Gly 
225                 230                 235                 240 


Glu Thr Ala Ala Gly Gly Arg Leu Leu His Leu Met Glu Ile Leu Asn 
                245                 250                 255     


Val Lys Asn Val Met Val Val Val Ser Arg Trp Tyr Gly Gly Ile Leu 
            260                 265                 270         


Leu Gly Pro Asp Arg Phe Lys His Ile Asn Asn Cys Ala Arg Asn Ile 
        275                 280                 285             


Leu Val Glu Lys Asn Tyr Thr Asn Ser Pro Glu Glu Ser Ser Lys Ala 
    290                 295                 300                 


Leu Gly Lys Asn Lys Lys Val Arg Lys Asp Lys Lys Arg Asn Glu His 
305                 310                 315                 320 


<210>  5489
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPAD1__Homo_sapiens__NP_060283

<400>  5489

Met Ala Pro Met Gly Ile Arg Leu Ser Pro Leu Gly Val Ala Val Phe 
1               5                   10                  15      


Cys Leu Leu Gly Leu Gly Val Leu Tyr His Leu Tyr Ser Gly Phe Leu 
            20                  25                  30          


Ala Gly Arg Phe Ser Leu Phe Gly Leu Gly Gly Glu Pro Gly Gly Gly 
        35                  40                  45              


Ala Ala Gly Pro Ala Ala Ala Ala Asp Gly Gly Thr Val Asp Leu Arg 
    50                  55                  60                  


Glu Met Leu Ala Val Ser Val Leu Ala Ala Val Arg Gly Gly Asp Glu 
65                  70                  75                  80  


Val Arg Arg Val Arg Glu Ser Asn Val Leu His Glu Lys Ser Lys Gly 
                85                  90                  95      


Lys Thr Arg Glu Gly Ala Glu Asp Lys Met Thr Ser Gly Asp Val Leu 
            100                 105                 110         


Ser Asn Arg Lys Met Phe Tyr Leu Leu Lys Thr Ala Phe Pro Ser Val 
        115                 120                 125             


Gln Ile Asn Thr Glu Glu His Val Asp Ala Ala Asp Gln Glu Val Ile 
    130                 135                 140                 


Leu Trp Asp His Lys Ile Pro Glu Asp Ile Leu Lys Glu Val Thr Thr 
145                 150                 155                 160 


Pro Lys Glu Val Pro Ala Glu Ser Val Thr Val Trp Ile Asp Pro Leu 
                165                 170                 175     


Asp Ala Thr Gln Glu Tyr Thr Glu Asp Leu Arg Lys Tyr Val Thr Thr 
            180                 185                 190         


Met Val Cys Val Ala Val Asn Gly Lys Pro Met Leu Gly Val Ile His 
        195                 200                 205             


Lys Pro Phe Ser Glu Tyr Thr Ala Trp Ala Met Val Asp Gly Gly Ser 
    210                 215                 220                 


Asn Val Lys Ala Arg Ser Ser Tyr Asn Glu Lys Thr Pro Arg Ile Val 
225                 230                 235                 240 


Val Ser Arg Ser His Ser Gly Met Val Lys Gln Val Ala Leu Gln Thr 
                245                 250                 255     


Phe Gly Asn Gln Thr Thr Ile Ile Pro Ala Gly Gly Ala Gly Tyr Lys 
            260                 265                 270         


Val Leu Ala Leu Leu Asp Val Pro Asp Lys Ser Gln Glu Lys Ala Asp 
        275                 280                 285             


Leu Tyr Ile His Val Thr Tyr Ile Lys Lys Trp Asp Ile Cys Ala Gly 
    290                 295                 300                 


Asn Ala Ile Leu Lys Ala Leu Gly Gly His Met Thr Thr Leu Ser Gly 
305                 310                 315                 320 


Glu Glu Ile Ser Tyr Thr Gly Ser Asp Gly Ile Glu Gly Gly Leu Leu 
                325                 330                 335     


Ala Ser Ile Arg Met Asn His Gln Ala Leu Val Arg Lys Leu Pro Asp 
            340                 345                 350         


Leu Glu Lys Thr Gly His Lys 
        355                 


<210>  5490
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPDH1__Homo_sapiens__NP_000874

<400>  5490

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Pro Arg Leu Asp Leu Ala Thr His Pro Thr Thr Pro Arg Ser Glu 
    50                  55                  60                  


Leu Ser Ser Val Val Leu Leu Ala Gly Val Gly Val Gln Met Asp Arg 
65                  70                  75                  80  


Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly 
                85                  90                  95      


Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala 
            100                 105                 110         


Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp 
        115                 120                 125             


Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile 
    130                 135                 140                 


Thr Leu Lys Thr Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu 
145                 150                 155                 160 


Ala Asp Met Ala Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile 
                165                 170                 175     


His His Asn Cys Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val 
            180                 185                 190         


Lys Lys Phe Glu Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro 
        195                 200                 205             


Ser His Thr Val Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe 
    210                 215                 220                 


Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val 
225                 230                 235                 240 


Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His 
                245                 250                 255     


Thr Thr Leu Leu Ser Glu Val Met Thr Pro Arg Ile Glu Leu Val Val 
            260                 265                 270         


Ala Pro Ala Gly Val Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg 
        275                 280                 285             


Ser Lys Lys Gly Lys Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val 
    290                 295                 300                 


Ala Ile Ile Ala Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu 
305                 310                 315                 320 


Ala Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly 
                325                 330                 335     


Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly 
            340                 345                 350         


Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln 
        355                 360                 365             


Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val 
    370                 375                 380                 


Ile Gly Gly Asn Val Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp 
385                 390                 395                 400 


Ala Gly Val Asp Gly Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys 
                405                 410                 415     


Ile Thr Gln Glu Val Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val 
            420                 425                 430         


Tyr Lys Val Ala Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala 
        435                 440                 445             


Asp Gly Gly Ile Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu 
    450                 455                 460                 


Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu 
465                 470                 475                 480 


Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr 
                485                 490                 495     


Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln 
            500                 505                 510         


Lys Arg Tyr Phe Ser Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val 
        515                 520                 525             


Ser Gly Ser Ile Gln Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr 
    530                 535                 540                 


Leu Ile Ala Gly Ile Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser 
545                 550                 555                 560 


Leu Ser Val Leu Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu 
                565                 570                 575     


Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His 
            580                 585                 590         


Ser Tyr Glu Lys Arg Leu Tyr 
        595                 


<210>  5491
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPDH2__Homo_sapiens__NP_000875

<400>  5491

Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Ser Tyr Val Pro Asp Asp 
1               5                   10                  15      


Gly Leu Thr Ala Gln Gln Leu Phe Asn Cys Gly Asp Gly Leu Thr Tyr 
            20                  25                  30          


Asn Asp Phe Leu Ile Leu Pro Gly Tyr Ile Asp Phe Thr Ala Asp Gln 
        35                  40                  45              


Val Asp Leu Thr Ser Ala Leu Thr Lys Lys Ile Thr Leu Lys Thr Pro 
    50                  55                  60                  


Leu Val Ser Ser Pro Met Asp Thr Val Thr Glu Ala Gly Met Ala Ile 
65                  70                  75                  80  


Ala Met Ala Leu Thr Gly Gly Ile Gly Phe Ile His His Asn Cys Thr 
                85                  90                  95      


Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val Lys Lys Tyr Glu Gln 
            100                 105                 110         


Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro Lys Asp Arg Val Arg 
        115                 120                 125             


Asp Val Phe Glu Ala Lys Ala Arg His Gly Phe Cys Gly Ile Pro Ile 
    130                 135                 140                 


Thr Asp Thr Gly Arg Met Gly Ser Arg Leu Val Gly Ile Ile Ser Ser 
145                 150                 155                 160 


Arg Asp Ile Asp Phe Leu Lys Glu Glu Glu His Asp Cys Phe Leu Glu 
                165                 170                 175     


Glu Ile Met Thr Lys Arg Glu Asp Leu Val Val Ala Pro Ala Gly Ile 
            180                 185                 190         


Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly Lys 
        195                 200                 205             


Leu Pro Ile Val Asn Glu Asp Asp Glu Leu Val Ala Ile Ile Ala Arg 
    210                 215                 220                 


Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp Ala 
225                 230                 235                 240 


Lys Lys Gln Leu Leu Cys Gly Ala Ala Ile Gly Thr His Glu Asp Asp 
                245                 250                 255     


Lys Tyr Arg Leu Asp Leu Leu Ala Gln Ala Gly Val Asp Val Val Val 
            260                 265                 270         


Leu Asp Ser Ser Gln Gly Asn Ser Ile Phe Gln Ile Asn Met Ile Lys 
        275                 280                 285             


Tyr Ile Lys Asp Lys Tyr Pro Asn Leu Gln Val Ile Gly Gly Asn Val 
    290                 295                 300                 


Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp Ala 
305                 310                 315                 320 


Leu Arg Val Gly Met Gly Ser Gly Ser Ile Cys Ile Thr Gln Glu Val 
                325                 330                 335     


Leu Ala Cys Gly Arg Pro Gln Ala Thr Ala Val Tyr Lys Val Ser Glu 
            340                 345                 350         


Tyr Ala Arg Arg Phe Gly Val Pro Val Ile Ala Asp Gly Gly Ile Gln 
        355                 360                 365             


Asn Val Gly His Ile Ala Lys Ala Leu Ala Leu Gly Ala Ser Thr Val 
    370                 375                 380                 


Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu Tyr 
385                 390                 395                 400 


Phe Phe Ser Asp Gly Ile Arg Leu Lys Lys Tyr Arg Gly Met Gly Ser 
                405                 410                 415     


Leu Asp Ala Met Asp Lys His Leu Ser Ser Gln Asn Arg Tyr Phe Ser 
            420                 425                 430         


Glu Ala Asp Lys Ile Lys Val Ala Gln Gly Val Ser Gly Ala Val Gln 
        435                 440                 445             


Asp Lys Gly Ser Ile His Lys Phe Val Pro Tyr Leu Ile Ala Gly Ile 
    450                 455                 460                 


Gln His Ser Cys Gln Asp Ile Gly Ala Lys Ser Leu Thr Gln Val Arg 
465                 470                 475                 480 


Ala Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Ser Ser 
                485                 490                 495     


Ala Gln Val Glu Gly Gly Val His Ser Leu His Ser Tyr Glu Lys Arg 
            500                 505                 510         


Leu Phe 
        


<210>  5492
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPG1__Homo_sapiens__NP_001269297

<400>  5492

Met Tyr Leu Glu Thr Arg Arg Ala Ile Phe Val Phe Trp Ile Phe Leu 
1               5                   10                  15      


Gln Val Gln Gly Thr Lys Val Cys Gln Glu Ala Val Trp Glu Ala Tyr 
            20                  25                  30          


Arg Ile Phe Leu Asp Arg Ile Pro Asp Thr Gly Glu Tyr Gln Asp Trp 
        35                  40                  45              


Val Ser Ile Cys Gln Gln Glu Thr Phe Cys Leu Phe Asp Ile Gly Lys 
    50                  55                  60                  


Asn Phe Ser Asn Ser Gln Glu His Leu Asp Leu Leu Gln Gln Arg Ile 
65                  70                  75                  80  


Lys Gln Arg Ser Phe Pro Asp Arg Lys Asp Glu Ile Ser Ala Glu Lys 
                85                  90                  95      


Thr Leu Gly Glu Pro Gly Glu Thr Ile Val Ile Ser Thr Asp Val Ala 
            100                 105                 110         


Asn Val Ser Leu Gly Pro Phe Pro Leu Thr Pro Asp Asp Thr Leu Leu 
        115                 120                 125             


Asn Glu Ile Leu Asp Asn Thr Leu Asn Asp Thr Lys Met Pro Thr Thr 
    130                 135                 140                 


Glu Arg Glu Thr Glu Phe Ala Val Leu Glu Glu Gln Arg Val Glu Leu 
145                 150                 155                 160 


Ser Val Ser Leu Val Asn Gln Lys Phe Lys Ala Glu Leu Ala Asp Ser 
                165                 170                 175     


Gln Ser Pro Tyr Tyr Gln Glu Leu Ala Gly Lys Ser Gln Leu Gln Met 
            180                 185                 190         


Gln Lys Ile Phe Lys Lys Leu Pro Gly Phe Lys Lys Ile His Val Leu 
        195                 200                 205             


Gly Phe Arg Pro Lys Lys Glu Lys Asp Gly Ser Ser Ser Thr Glu Met 
    210                 215                 220                 


Gln Leu Thr Ala Ile Phe Lys Arg His Ser Ala Glu Ala Lys Ser Pro 
225                 230                 235                 240 


Ala Ser Asp Leu Leu Ser Phe Asp Ser Asn Lys Ile Glu Ser Glu Glu 
                245                 250                 255     


Val Tyr His Gly Thr Met Glu Glu Asp Lys Gln Pro Glu Ile Tyr Leu 
            260                 265                 270         


Thr Ala Thr Asp Leu Lys Arg Leu Ile Ser Lys Ala Leu Glu Glu Glu 
        275                 280                 285             


Gln Ser Leu Asp Val Gly Thr Ile Gln Phe Thr Asp Glu Ile Ala Gly 
    290                 295                 300                 


Ser Leu Pro Ala Phe Gly Pro Asp Thr Gln Ser Glu Leu Pro Thr Ser 
305                 310                 315                 320 


Phe Ala Val Ile Thr Glu Asp Ala Thr Leu Ser Pro Glu Leu Pro Pro 
                325                 330                 335     


Val Glu Pro Gln Leu Glu Thr Val Asp Gly Ala Glu His Gly Leu Pro 
            340                 345                 350         


Asp Thr Ser Trp Ser Pro Pro Ala Met Ala Ser Thr Ser Leu Ser Glu 
        355                 360                 365             


Ala Pro Pro Phe Phe Met Ala Ser Ser Ile Phe Ser Leu Thr Asp Gln 
    370                 375                 380                 


Gly Thr Thr Asp Thr Met Ala Thr Asp Gln Thr Met Leu Val Pro Gly 
385                 390                 395                 400 


Leu Thr Ile Pro Thr Ser Asp Tyr Ser Ala Ile Ser Gln Leu Ala Leu 
                405                 410                 415     


Gly Ile Ser His Pro Pro Ala Ser Ser Asp Asp Ser Arg Ser Ser Ala 
            420                 425                 430         


Gly Gly Glu Asp Met Val Arg His Leu Asp Glu Met Asp Leu Ser Asp 
        435                 440                 445             


Thr Pro Ala Pro Ser Glu Val Pro Glu Leu Ser Glu Tyr Val Ser Val 
    450                 455                 460                 


Pro Asp His Phe Leu Glu Asp Thr Thr Pro Val Ser Ala Leu Gln Tyr 
465                 470                 475                 480 


Ile Thr Thr Ser Ser Met Thr Ile Ala Pro Lys Gly Arg Glu Leu Val 
                485                 490                 495     


Val Phe Phe Ser Leu Arg Val Ala Asn Met Ala Phe Ser Asn Asp Leu 
            500                 505                 510         


Phe Asn Lys Ser Ser Leu Glu Tyr Arg Ala Leu Glu Gln Gln Phe Thr 
        515                 520                 525             


Gln Leu Leu Val Pro Tyr Leu Arg Ser Asn Leu Thr Gly Phe Lys Gln 
    530                 535                 540                 


Leu Glu Ile Leu Asn Phe Arg Asn Gly Ser Val Ile Val Asn Ser Lys 
545                 550                 555                 560 


Met Lys Phe Ala Lys Ser Val Pro Tyr Asn Leu Thr Lys Ala Val His 
                565                 570                 575     


Gly Val Leu Glu Asp Phe Arg Ser Ala Ala Ala Gln Gln Leu His Leu 
            580                 585                 590         


Glu Ile Asp Ser Tyr Ser Leu Asn Ile Glu Pro Ala Asp Gln Ala Asp 
        595                 600                 605             


Pro Cys Lys Phe Leu Ala Cys Gly Glu Phe Ala Gln Cys Val Lys Asn 
    610                 615                 620                 


Glu Arg Thr Glu Glu Ala Glu Cys Arg Cys Lys Pro Gly Tyr Asp Ser 
625                 630                 635                 640 


Gln Gly Ser Leu Asp Gly Leu Glu Pro Gly Leu Cys Gly Pro Gly Thr 
                645                 650                 655     


Lys Glu Cys Glu Val Leu Gln Gly Lys Gly Ala Pro Cys Arg Leu Pro 
            660                 665                 670         


Asp His Ser Glu Asn Gln Ala Tyr Lys Thr Ser Val Lys Lys Phe Gln 
        675                 680                 685             


Asn Gln Gln Asn Asn Lys Val Ile Ser Lys Arg Asn Ser Glu Leu Leu 
    690                 695                 700                 


Thr Val Glu Tyr Glu Glu Phe Asn His Gln Asp Trp Glu Gly Asn 
705                 710                 715                 


<210>  5493
<211>  1241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMPG2__Homo_sapiens__NP_057331

<400>  5493

Met Ile Met Phe Pro Leu Phe Gly Lys Ile Ser Leu Gly Ile Leu Ile 
1               5                   10                  15      


Phe Val Leu Ile Glu Gly Asp Phe Pro Ser Leu Thr Ala Gln Thr Tyr 
            20                  25                  30          


Leu Ser Ile Glu Glu Ile Gln Glu Pro Lys Ser Ala Val Ser Phe Leu 
        35                  40                  45              


Leu Pro Glu Glu Ser Thr Asp Leu Ser Leu Ala Thr Lys Lys Lys Gln 
    50                  55                  60                  


Pro Leu Asp Arg Arg Glu Thr Glu Arg Gln Trp Leu Ile Arg Arg Arg 
65                  70                  75                  80  


Arg Ser Ile Leu Phe Pro Asn Gly Val Lys Ile Cys Pro Asp Glu Ser 
                85                  90                  95      


Val Ala Glu Ala Val Ala Asn His Val Lys Tyr Phe Lys Val Arg Val 
            100                 105                 110         


Cys Gln Glu Ala Val Trp Glu Ala Phe Arg Thr Phe Trp Asp Arg Leu 
        115                 120                 125             


Pro Gly Arg Glu Glu Tyr His Tyr Trp Met Asn Leu Cys Glu Asp Gly 
    130                 135                 140                 


Val Thr Ser Ile Phe Glu Met Gly Thr Asn Phe Ser Glu Ser Val Glu 
145                 150                 155                 160 


His Arg Ser Leu Ile Met Lys Lys Leu Thr Tyr Ala Lys Glu Thr Val 
                165                 170                 175     


Ser Ser Ser Glu Leu Ser Ser Pro Val Pro Val Gly Asp Thr Ser Thr 
            180                 185                 190         


Leu Gly Asp Thr Thr Leu Ser Val Pro His Pro Glu Val Asp Ala Tyr 
        195                 200                 205             


Glu Gly Ala Ser Glu Ser Ser Leu Glu Arg Pro Glu Glu Ser Ile Ser 
    210                 215                 220                 


Asn Glu Ile Glu Asn Val Ile Glu Glu Ala Thr Lys Pro Ala Gly Glu 
225                 230                 235                 240 


Gln Ile Ala Glu Phe Ser Ile His Leu Leu Gly Lys Gln Tyr Arg Glu 
                245                 250                 255     


Glu Leu Gln Asp Ser Ser Ser Phe His His Gln His Leu Glu Glu Glu 
            260                 265                 270         


Phe Ile Ser Glu Val Glu Asn Ala Phe Thr Gly Leu Pro Gly Tyr Lys 
        275                 280                 285             


Glu Ile Arg Val Leu Glu Phe Arg Ser Pro Lys Glu Asn Asp Ser Gly 
    290                 295                 300                 


Val Asp Val Tyr Tyr Ala Val Thr Phe Asn Gly Glu Ala Ile Ser Asn 
305                 310                 315                 320 


Thr Thr Trp Asp Leu Ile Ser Leu His Ser Asn Lys Val Glu Asn His 
                325                 330                 335     


Gly Leu Val Glu Leu Asp Asp Lys Pro Thr Val Val Tyr Thr Ile Ser 
            340                 345                 350         


Asn Phe Arg Asp Tyr Ile Ala Glu Thr Leu Gln Gln Asn Phe Leu Leu 
        355                 360                 365             


Gly Asn Ser Ser Leu Asn Pro Asp Pro Asp Ser Leu Gln Leu Ile Asn 
    370                 375                 380                 


Val Arg Gly Val Leu Arg His Gln Thr Glu Asp Leu Val Trp Asn Thr 
385                 390                 395                 400 


Gln Ser Ser Ser Leu Gln Ala Thr Pro Ser Ser Ile Leu Asp Asn Thr 
                405                 410                 415     


Phe Gln Ala Ala Trp Pro Ser Ala Asp Glu Ser Ile Thr Ser Ser Ile 
            420                 425                 430         


Pro Pro Leu Asp Phe Ser Ser Gly Pro Pro Ser Ala Thr Gly Arg Glu 
        435                 440                 445             


Leu Trp Ser Glu Ser Pro Leu Gly Asp Leu Val Ser Thr His Lys Leu 
    450                 455                 460                 


Ala Phe Pro Ser Lys Met Gly Leu Ser Ser Ser Pro Glu Val Leu Glu 
465                 470                 475                 480 


Val Ser Ser Leu Thr Leu His Ser Val Thr Pro Ala Val Leu Gln Thr 
                485                 490                 495     


Gly Leu Pro Val Ala Ser Glu Glu Arg Thr Ser Gly Ser His Leu Val 
            500                 505                 510         


Glu Asp Gly Leu Ala Asn Val Glu Glu Ser Glu Asp Phe Leu Ser Ile 
        515                 520                 525             


Asp Ser Leu Pro Ser Ser Ser Phe Thr Gln Pro Val Pro Lys Glu Thr 
    530                 535                 540                 


Ile Pro Ser Met Glu Asp Ser Asp Val Ser Leu Thr Ser Ser Pro Tyr 
545                 550                 555                 560 


Leu Thr Ser Ser Ile Pro Phe Gly Leu Asp Ser Leu Thr Ser Lys Val 
                565                 570                 575     


Lys Asp Gln Leu Lys Val Ser Pro Phe Leu Pro Asp Ala Ser Met Glu 
            580                 585                 590         


Lys Glu Leu Ile Phe Asp Gly Gly Leu Gly Ser Gly Ser Gly Gln Lys 
        595                 600                 605             


Val Asp Leu Ile Thr Trp Pro Trp Ser Glu Thr Ser Ser Glu Lys Ser 
    610                 615                 620                 


Ala Glu Pro Leu Ser Lys Pro Trp Leu Glu Asp Asp Asp Ser Leu Leu 
625                 630                 635                 640 


Pro Ala Glu Ile Glu Asp Lys Lys Leu Val Leu Val Asp Lys Met Asp 
                645                 650                 655     


Ser Thr Asp Gln Ile Ser Lys His Ser Lys Tyr Glu His Asp Asp Arg 
            660                 665                 670         


Ser Thr His Phe Pro Glu Glu Glu Pro Leu Ser Gly Pro Ala Val Pro 
        675                 680                 685             


Ile Phe Ala Asp Thr Ala Ala Glu Ser Ala Ser Leu Thr Leu Pro Lys 
    690                 695                 700                 


His Ile Ser Glu Val Pro Gly Val Asp Asp Tyr Ser Val Thr Lys Ala 
705                 710                 715                 720 


Pro Leu Ile Leu Thr Ser Val Ala Ile Ser Ala Ser Thr Asp Lys Ser 
                725                 730                 735     


Asp Gln Ala Asp Ala Ile Leu Arg Glu Asp Met Glu Gln Ile Thr Glu 
            740                 745                 750         


Ser Ser Asn Tyr Glu Trp Phe Asp Ser Glu Val Ser Met Val Lys Pro 
        755                 760                 765             


Asp Met Gln Thr Leu Trp Thr Ile Leu Pro Glu Ser Glu Arg Val Trp 
    770                 775                 780                 


Thr Arg Thr Ser Ser Leu Glu Lys Leu Ser Arg Asp Ile Leu Ala Ser 
785                 790                 795                 800 


Thr Pro Gln Ser Ala Asp Arg Leu Trp Leu Ser Val Thr Gln Ser Thr 
                805                 810                 815     


Lys Leu Pro Pro Thr Thr Ile Ser Thr Leu Leu Glu Asp Glu Val Ile 
            820                 825                 830         


Met Gly Val Gln Asp Ile Ser Leu Glu Leu Asp Arg Ile Gly Thr Asp 
        835                 840                 845             


Tyr Tyr Gln Pro Glu Gln Val Gln Glu Gln Asn Gly Lys Val Gly Ser 
    850                 855                 860                 


Tyr Val Glu Met Ser Thr Ser Val His Ser Thr Glu Met Val Ser Val 
865                 870                 875                 880 


Ala Trp Pro Thr Glu Gly Gly Asp Asp Leu Ser Tyr Thr Gln Thr Ser 
                885                 890                 895     


Gly Ala Leu Val Val Phe Phe Ser Leu Arg Val Thr Asn Met Met Phe 
            900                 905                 910         


Ser Glu Asp Leu Phe Asn Lys Asn Ser Leu Glu Tyr Lys Ala Leu Glu 
        915                 920                 925             


Gln Arg Phe Leu Glu Leu Leu Val Pro Tyr Leu Gln Ser Asn Leu Thr 
    930                 935                 940                 


Gly Phe Gln Asn Leu Glu Ile Leu Asn Phe Arg Asn Gly Ser Ile Val 
945                 950                 955                 960 


Val Asn Ser Arg Met Lys Phe Ala Asn Ser Val Pro Pro Asn Val Asn 
                965                 970                 975     


Asn Ala Val Tyr Met Ile Leu Glu Asp Phe Cys Thr Thr Ala Tyr Asn 
            980                 985                 990         


Thr Met Asn Leu Ala Ile Asp Lys  Tyr Ser Leu Asp Val  Glu Ser Gly 
        995                 1000                 1005             


Asp Glu  Ala Asn Pro Cys Lys  Phe Gln Ala Cys Asn  Glu Phe Ser 
    1010                 1015                 1020             


Glu Cys  Leu Val Asn Pro Trp  Ser Gly Glu Ala Lys  Cys Arg Cys 
    1025                 1030                 1035             


Phe Pro  Gly Tyr Leu Ser Val  Glu Glu Arg Pro Cys  Gln Ser Leu 
    1040                 1045                 1050             


Cys Asp  Leu Gln Pro Asp Phe  Cys Leu Asn Asp Gly  Lys Cys Asp 
    1055                 1060                 1065             


Ile Met  Pro Gly His Gly Ala  Ile Cys Arg Cys Arg  Val Gly Glu 
    1070                 1075                 1080             


Asn Trp  Trp Tyr Arg Gly Lys  His Cys Glu Glu Phe  Val Ser Glu 
    1085                 1090                 1095             


Pro Val  Ile Ile Gly Ile Thr  Ile Ala Ser Val Val  Gly Leu Leu 
    1100                 1105                 1110             


Val Ile  Phe Ser Ala Ile Ile  Tyr Phe Phe Ile Arg  Thr Leu Gln 
    1115                 1120                 1125             


Ala His  His Asp Arg Ser Glu  Arg Glu Ser Pro Phe  Ser Gly Ser 
    1130                 1135                 1140             


Ser Arg  Gln Pro Asp Ser Leu  Ser Ser Ile Glu Asn  Ala Val Lys 
    1145                 1150                 1155             


Tyr Asn  Pro Val Tyr Glu Ser  His Arg Ala Gly Cys  Glu Lys Tyr 
    1160                 1165                 1170             


Glu Gly  Pro Tyr Pro Gln His  Pro Phe Tyr Ser Ser  Ala Ser Gly 
    1175                 1180                 1185             


Asp Val  Ile Gly Gly Leu Ser  Arg Glu Glu Ile Arg  Gln Met Tyr 
    1190                 1195                 1200             


Glu Ser  Ser Glu Leu Ser Arg  Glu Glu Ile Gln Glu  Arg Met Arg 
    1205                 1210                 1215             


Val Leu  Glu Leu Tyr Ala Asn  Asp Pro Glu Phe Ala  Ala Phe Val 
    1220                 1225                 1230             


Arg Glu  Gln Gln Val Glu Glu  Val 
    1235                 1240     


<210>  5494
<211>  1912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INADL__Homo_sapiens__XP_011538767

<400>  5494

Met Pro Glu Asn Pro Ala Thr Asp Lys Leu Gln Val Leu Gln Val Leu 
1               5                   10                  15      


Asp Arg Leu Lys Met Lys Leu Gln Glu Lys Gly Asp Thr Ser Gln Asn 
            20                  25                  30          


Glu Lys Leu Ser Met Phe Tyr Glu Thr Leu Lys Ser Pro Leu Phe Asn 
        35                  40                  45              


Gln Ile Leu Thr Leu Gln Gln Ser Ile Lys Gln Leu Lys Gly Gln Leu 
    50                  55                  60                  


Asn His Ile Pro Ser Asp Cys Ser Ala Asn Phe Asp Phe Ser Arg Lys 
65                  70                  75                  80  


Gly Leu Leu Val Phe Thr Asp Gly Ser Ile Thr Asn Gly Asn Val His 
                85                  90                  95      


Arg Pro Ser Asn Asn Ser Thr Val Ser Gly Leu Phe Pro Trp Thr Pro 
            100                 105                 110         


Lys Leu Gly Asn Glu Asp Phe Asn Ser Val Ile Gln Gln Met Ala Gln 
        115                 120                 125             


Gly Arg Gln Ile Glu Tyr Ile Asp Ile Glu Arg Pro Ser Thr Gly Gly 
    130                 135                 140                 


Leu Gly Phe Ser Val Val Ala Leu Arg Ser Gln Asn Leu Gly Lys Val 
145                 150                 155                 160 


Asp Ile Phe Val Lys Asp Val Gln Pro Gly Ser Val Ala Asp Arg Asp 
                165                 170                 175     


Gln Arg Leu Lys Glu Asn Asp Gln Ile Leu Ala Ile Asn His Thr Pro 
            180                 185                 190         


Leu Asp Gln Asn Ile Ser His Gln Gln Ala Ile Ala Leu Leu Gln Gln 
        195                 200                 205             


Thr Thr Gly Ser Leu Arg Leu Ile Val Ala Arg Glu Pro Val His Thr 
    210                 215                 220                 


Lys Ser Ser Thr Ser Ser Ser Leu Asn Asp Thr Thr Leu Pro Glu Thr 
225                 230                 235                 240 


Val Cys Trp Gly His Val Glu Glu Val Glu Leu Ile Asn Asp Gly Ser 
                245                 250                 255     


Gly Leu Gly Phe Gly Ile Val Gly Gly Lys Thr Ser Gly Val Val Val 
            260                 265                 270         


Arg Thr Ile Val Pro Gly Gly Leu Ala Asp Arg Asp Gly Arg Leu Gln 
        275                 280                 285             


Thr Gly Asp His Ile Leu Lys Ile Gly Gly Thr Asn Val Gln Gly Met 
    290                 295                 300                 


Thr Ser Glu Gln Val Ala Gln Val Leu Arg Asn Cys Gly Asn Ser Val 
305                 310                 315                 320 


Arg Met Leu Val Ala Arg Asp Pro Ala Gly Asp Ile Ser Val Thr Pro 
                325                 330                 335     


Pro Ala Pro Ala Ala Leu Pro Val Ala Leu Pro Thr Val Ala Ser Lys 
            340                 345                 350         


Gly Pro Gly Ser Asp Ser Ser Leu Phe Glu Thr Tyr Asn Val Glu Leu 
        355                 360                 365             


Val Arg Lys Asp Gly Gln Ser Leu Gly Ile Arg Ile Val Gly Tyr Val 
    370                 375                 380                 


Gly Thr Ser His Thr Gly Glu Ala Ser Gly Ile Tyr Val Lys Ser Ile 
385                 390                 395                 400 


Ile Pro Gly Ser Ala Ala Tyr His Asn Gly His Ile Gln Val Asn Asp 
                405                 410                 415     


Lys Ile Val Ala Val Asp Gly Val Asn Ile Gln Gly Phe Ala Asn His 
            420                 425                 430         


Asp Val Val Glu Val Leu Arg Asn Ala Gly Gln Val Val His Leu Thr 
        435                 440                 445             


Leu Val Arg Arg Lys Thr Ser Ser Ser Thr Ser Pro Leu Glu Pro Pro 
    450                 455                 460                 


Ser Asp Arg Gly Thr Val Val Glu Pro Leu Lys Pro Pro Ala Leu Phe 
465                 470                 475                 480 


Leu Thr Gly Ala Val Glu Thr Glu Thr Asn Val Asp Gly Glu Asp Glu 
                485                 490                 495     


Glu Ile Lys Glu Arg Ile Asp Thr Leu Lys Asn Asp Asn Ile Gln Ala 
            500                 505                 510         


Leu Glu Lys Leu Glu Lys Val Pro Asp Ser Pro Glu Asn Glu Leu Lys 
        515                 520                 525             


Ser Arg Trp Glu Asn Leu Leu Gly Pro Asp Tyr Glu Val Met Val Ala 
    530                 535                 540                 


Thr Leu Asp Thr Gln Ile Ala Asp Asp Ala Glu Leu Gln Lys Tyr Ser 
545                 550                 555                 560 


Lys Leu Leu Pro Ile His Thr Leu Arg Leu Gly Val Glu Val Asp Ser 
                565                 570                 575     


Phe Asp Gly His His Tyr Ile Ser Ser Ile Val Ser Gly Gly Pro Val 
            580                 585                 590         


Asp Thr Leu Gly Leu Leu Gln Pro Glu Asp Glu Leu Leu Glu Val Asn 
        595                 600                 605             


Gly Met Gln Leu Tyr Gly Lys Ser Arg Arg Glu Ala Val Ser Phe Leu 
    610                 615                 620                 


Lys Glu Val Pro Pro Pro Phe Thr Leu Val Cys Cys Arg Arg Leu Phe 
625                 630                 635                 640 


Asp Asp Glu Ala Ser Val Asp Glu Pro Arg Arg Thr Glu Thr Ser Leu 
                645                 650                 655     


Pro Glu Thr Glu Val Asp His Asn Met Asp Val Asn Thr Glu Glu Asp 
            660                 665                 670         


Asp Asp Gly Glu Leu Ala Leu Trp Ser Pro Glu Val Lys Ile Val Glu 
        675                 680                 685             


Leu Val Lys Asp Cys Lys Gly Leu Gly Phe Ser Ile Leu Asp Tyr Gln 
    690                 695                 700                 


Asp Pro Leu Asp Pro Thr Arg Ser Val Ile Val Ile Arg Ser Leu Val 
705                 710                 715                 720 


Ala Asp Gly Val Ala Glu Arg Ser Gly Gly Leu Leu Pro Gly Asp Arg 
                725                 730                 735     


Leu Val Ser Val Asn Glu Tyr Cys Leu Asp Asn Thr Ser Leu Ala Glu 
            740                 745                 750         


Ala Val Glu Ile Leu Lys Ala Val Pro Pro Gly Leu Val His Leu Gly 
        755                 760                 765             


Ile Cys Lys Pro Leu Val Glu Asp Asn Glu Glu Glu Ser Cys Tyr Ile 
    770                 775                 780                 


Leu His Ser Ser Ser Asn Glu Asp Lys Thr Glu Phe Ser Gly Thr Ile 
785                 790                 795                 800 


His Asp Ile Asn Ser Ser Leu Ile Leu Glu Ala Pro Lys Gly Phe Arg 
                805                 810                 815     


Asp Glu Pro Tyr Phe Lys Glu Glu Leu Val Asp Glu Pro Phe Leu Asp 
            820                 825                 830         


Leu Gly Lys Ser Phe His Ser Gln Gln Lys Glu Ile Glu Gln Ser Lys 
        835                 840                 845             


Glu Ala Trp Glu Met His Glu Phe Leu Thr Pro Arg Leu Gln Glu Met 
    850                 855                 860                 


Asp Glu Glu Arg Glu Ile Leu Val Asp Glu Glu Tyr Glu Leu Tyr Gln 
865                 870                 875                 880 


Asp Pro Ser Pro Ser Met Glu Leu Tyr Pro Leu Ser His Ile Gln Glu 
                885                 890                 895     


Ala Thr Pro Val Pro Ser Val Asn Glu Leu His Phe Gly Thr Gln Trp 
            900                 905                 910         


Leu His Asp Asn Glu Pro Ser Glu Ser Gln Glu Ala Arg Thr Gly Arg 
        915                 920                 925             


Thr Val Tyr Ser Gln Glu Ala Gln Pro Tyr Gly Tyr Cys Pro Glu Asn 
    930                 935                 940                 


Val Met Lys Glu Asn Phe Val Met Glu Ser Leu Pro Ser Val Pro Ser 
945                 950                 955                 960 


Thr Glu Gly Asn Ser Gln Gln Gly Arg Phe Asp Asp Leu Glu Asn Leu 
                965                 970                 975     


Asn Ser Leu Ala Lys Thr Ser Leu Asp Leu Gly Met Ile Pro Asn Asp 
            980                 985                 990         


Val Gln Gly Pro Ser Leu Leu Ile  Asp Leu Pro Val Val  Ala Gln Arg 
        995                 1000                 1005             


Arg Glu  Gln Glu Asp Leu Pro  Leu Tyr Gln His Gln  Ala Thr Arg 
    1010                 1015                 1020             


Val Ile  Ser Lys Ala Ser Ala  Tyr Thr Gly Met Leu  Ser Ser Arg 
    1025                 1030                 1035             


Tyr Ala  Thr Asp Thr Cys Glu  Leu Pro Glu Arg Glu  Glu Gly Glu 
    1040                 1045                 1050             


Gly Glu  Glu Thr Pro Asn Phe  Ser His Trp Gly Pro  Pro Arg Ile 
    1055                 1060                 1065             


Val Glu  Ile Phe Arg Glu Pro  Asn Val Ser Leu Gly  Ile Ser Ile 
    1070                 1075                 1080             


Val Gly  Gly Gln Thr Val Ile  Lys Arg Leu Lys Asn  Gly Glu Glu 
    1085                 1090                 1095             


Leu Lys  Gly Ile Phe Ile Lys  Gln Val Leu Glu Asp  Ser Pro Ala 
    1100                 1105                 1110             


Gly Lys  Thr Asn Ala Leu Lys  Thr Gly Asp Lys Ile  Leu Glu Val 
    1115                 1120                 1125             


Ser Gly  Val Asp Leu Gln Asn  Ala Ser His Ser Glu  Ala Val Glu 
    1130                 1135                 1140             


Ala Ile  Lys Asn Ala Gly Asn  Pro Val Val Phe Ile  Val Gln Ser 
    1145                 1150                 1155             


Leu Ser  Ser Thr Pro Arg Val  Ile Pro Asn Val His  Asn Lys Ala 
    1160                 1165                 1170             


Asn Lys  Ile Thr Gly Asn Gln  Asn Gln Asp Thr Gln  Glu Lys Lys 
    1175                 1180                 1185             


Glu Lys  Arg Gln Gly Thr Ala  Pro Pro Pro Met Lys  Leu Pro Pro 
    1190                 1195                 1200             


Pro Tyr  Lys Ala Leu Thr Asp  Asp Ser Asp Glu Asn  Glu Glu Glu 
    1205                 1210                 1215             


Asp Ala  Phe Thr Asp Gln Lys  Ile Arg Gln Arg Tyr  Ala Asp Leu 
    1220                 1225                 1230             


Pro Gly  Glu Leu His Ile Ile  Glu Leu Glu Lys Asp  Lys Asn Gly 
    1235                 1240                 1245             


Leu Gly  Leu Ser Leu Ala Gly  Asn Lys Asp Arg Ser  Arg Met Ser 
    1250                 1255                 1260             


Ile Phe  Val Val Gly Ile Asn  Pro Glu Gly Pro Ala  Ala Ala Asp 
    1265                 1270                 1275             


Gly Arg  Met Arg Ile Gly Asp  Glu Leu Leu Glu Ile  Asn Asn Gln 
    1280                 1285                 1290             


Ile Leu  Tyr Gly Arg Ser His  Gln Asn Ala Ser Ala  Ile Ile Lys 
    1295                 1300                 1305             


Thr Ala  Pro Ser Lys Val Lys  Leu Val Phe Ile Arg  Asn Glu Asp 
    1310                 1315                 1320             


Ala Val  Asn Gln Met Ala Val  Thr Pro Phe Pro Val  Pro Ser Ser 
    1325                 1330                 1335             


Ser Pro  Ser Ser Ile Glu Asp  Gln Ser Gly Thr Glu  Pro Ile Ser 
    1340                 1345                 1350             


Ser Glu  Glu Asp Gly Ser Val  Glu Val Gly Ile Lys  Gln Leu Pro 
    1355                 1360                 1365             


Glu Ser  Glu Ser Phe Lys Leu  Ala Val Ser Gln Met  Lys Gln Gln 
    1370                 1375                 1380             


Lys Tyr  Pro Thr Lys Val Ser  Phe Ser Ser Gln Glu  Ile Pro Leu 
    1385                 1390                 1395             


Ala Pro  Ala Ser Ser Tyr His  Ser Thr Asp Ala Asp  Phe Thr Gly 
    1400                 1405                 1410             


Tyr Gly  Gly Phe Gln Ala Pro  Leu Ser Val Asp Pro  Ala Thr Cys 
    1415                 1420                 1425             


Pro Ile  Val Pro Gly Gln Glu  Met Ile Ile Glu Ile  Ser Lys Gly 
    1430                 1435                 1440             


Arg Ser  Gly Leu Gly Leu Ser  Ile Val Gly Gly Lys  Asp Thr Pro 
    1445                 1450                 1455             


Leu Phe  Trp Arg Leu Gly Ser  Pro Arg Ala Trp Ser  Gln His Leu 
    1460                 1465                 1470             


Val Arg  Ala Phe Met Leu His  His Pro Val Thr Glu  Val Glu Gly 
    1475                 1480                 1485             


Gln Asn  Ala Ile Val Ile His  Glu Val Tyr Glu Glu  Gly Ala Ala 
    1490                 1495                 1500             


Ala Arg  Asp Gly Arg Leu Trp  Ala Gly Asp Gln Ile  Leu Glu Val 
    1505                 1510                 1515             


Asn Gly  Val Asp Leu Arg Asn  Ser Ser His Glu Glu  Ala Ile Thr 
    1520                 1525                 1530             


Ala Leu  Arg Gln Thr Pro Gln  Lys Val Arg Leu Val  Val Tyr Arg 
    1535                 1540                 1545             


Asp Glu  Ala His Tyr Arg Asp  Glu Glu Asn Leu Glu  Ile Phe Pro 
    1550                 1555                 1560             


Val Asp  Leu Gln Lys Lys Ala  Gly Arg Gly Leu Gly  Leu Ser Ile 
    1565                 1570                 1575             


Val Gly  Lys Arg Asn Gly Ser  Gly Val Phe Ile Ser  Asp Ile Val 
    1580                 1585                 1590             


Lys Gly  Gly Ala Ala Asp Leu  Asp Gly Arg Leu Ile  Gln Gly Asp 
    1595                 1600                 1605             


Gln Ile  Leu Ser Val Asn Gly  Glu Asp Met Arg Asn  Ala Ser Gln 
    1610                 1615                 1620             


Glu Thr  Val Ala Thr Ile Leu  Lys Cys Ala Gln Gly  Leu Val Gln 
    1625                 1630                 1635             


Leu Glu  Ile Gly Arg Leu Arg  Ala Gly Ser Trp Thr  Ser Ala Arg 
    1640                 1645                 1650             


Thr Thr  Ser Gln Asn Ser Gln  Gly Ser Gln Gln Ser  Ala His Ser 
    1655                 1660                 1665             


Ser Cys  His Pro Ser Phe Ala  Pro Val Ile Thr Gly  Leu Gln Asn 
    1670                 1675                 1680             


Leu Val  Gly Thr Lys Arg Val  Ser Asp Pro Ser Gln  Lys Asn Ser 
    1685                 1690                 1695             


Gly Thr  Asp Met Glu Pro Arg  Thr Val Glu Ile Asn  Arg Glu Leu 
    1700                 1705                 1710             


Ser Asp  Ala Leu Gly Ile Ser  Ile Ala Gly Gly Arg  Gly Ser Pro 
    1715                 1720                 1725             


Leu Gly  Asp Ile Pro Val Phe  Ile Ala Met Ile Gln  Ala Ser Gly 
    1730                 1735                 1740             


Val Ala  Ala Arg Thr Gln Lys  Leu Lys Val Gly Asp  Arg Ile Val 
    1745                 1750                 1755             


Ser Ile  Asn Gly Gln Pro Leu  Asp Gly Leu Ser His  Ala Asp Val 
    1760                 1765                 1770             


Val Asn  Leu Leu Lys Asn Ala  Tyr Gly Arg Ile Ile  Leu Gln Val 
    1775                 1780                 1785             


Val Ala  Asp Thr Asn Ile Ser  Ala Ile Ala Ala Gln  Leu Glu Asn 
    1790                 1795                 1800             


Met Ser  Thr Gly Tyr His Leu  Gly Ser Pro Thr Ala  Glu His His 
    1805                 1810                 1815             


Pro Glu  Asp Thr Glu Thr Pro  Pro Pro Lys Ile Ile  Thr Leu Glu 
    1820                 1825                 1830             


Lys Gly  Ser Glu Gly Leu Gly  Phe Ser Ile Val Gly  Gly Tyr Gly 
    1835                 1840                 1845             


Ser Pro  His Gly Asp Leu Pro  Ile Tyr Val Lys Thr  Val Phe Ala 
    1850                 1855                 1860             


Lys Gly  Ala Ala Ala Asp Asp  Gly Arg Leu Lys Arg  Gly Asp Gln 
    1865                 1870                 1875             


Ile Leu  Ala Val Asn Gly Glu  Thr Leu Glu Gly Val  Thr His Glu 
    1880                 1885                 1890             


Gln Ala  Val Ala Ile Leu Lys  His Gln Arg Gly Thr  Val Thr Leu 
    1895                 1900                 1905             


Thr Val  Leu Ser 
    1910         


<210>  5495
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INA__Homo_sapiens__NP_116116

<400>  5495

Met Ser Phe Gly Ser Glu His Tyr Leu Cys Ser Ser Ser Ser Tyr Arg 
1               5                   10                  15      


Lys Val Phe Gly Asp Gly Ser Arg Leu Ser Ala Arg Leu Ser Gly Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Phe Arg Ser Gln Ser Leu Ser Arg Ser Asn Val 
        35                  40                  45              


Ala Ser Ser Ala Ala Cys Ser Ser Ala Ser Ser Leu Gly Leu Gly Leu 
    50                  55                  60                  


Ala Tyr Arg Arg Pro Pro Ala Ser Asp Gly Leu Asp Leu Ser Gln Ala 
65                  70                  75                  80  


Ala Ala Arg Thr Asn Glu Tyr Lys Ile Ile Arg Thr Asn Glu Lys Glu 
                85                  90                  95      


Gln Leu Gln Gly Leu Asn Asp Arg Phe Ala Val Phe Ile Glu Lys Val 
            100                 105                 110         


His Gln Leu Glu Thr Gln Asn Arg Ala Leu Glu Ala Glu Leu Ala Ala 
        115                 120                 125             


Leu Arg Gln Arg His Ala Glu Pro Ser Arg Val Gly Glu Leu Phe Gln 
    130                 135                 140                 


Arg Glu Leu Arg Asp Leu Arg Ala Gln Leu Glu Glu Ala Ser Ser Ala 
145                 150                 155                 160 


Arg Ser Gln Ala Leu Leu Glu Arg Asp Gly Leu Ala Glu Glu Val Gln 
                165                 170                 175     


Arg Leu Arg Ala Arg Cys Glu Glu Glu Ser Arg Gly Arg Glu Gly Ala 
            180                 185                 190         


Glu Arg Ala Leu Lys Ala Gln Gln Arg Asp Val Asp Gly Ala Thr Leu 
        195                 200                 205             


Ala Arg Leu Asp Leu Glu Lys Lys Val Glu Ser Leu Leu Asp Glu Leu 
    210                 215                 220                 


Ala Phe Val Arg Gln Val His Asp Glu Glu Val Ala Glu Leu Leu Ala 
225                 230                 235                 240 


Thr Leu Gln Ala Ser Ser Gln Ala Ala Ala Glu Val Asp Val Thr Val 
                245                 250                 255     


Ala Lys Pro Asp Leu Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Tyr 
            260                 265                 270         


Glu Ser Leu Ala Ala Lys Asn Leu Gln Ser Ala Glu Glu Trp Tyr Lys 
        275                 280                 285             


Ser Lys Phe Ala Asn Leu Asn Glu Gln Ala Ala Arg Ser Thr Glu Ala 
    290                 295                 300                 


Ile Arg Ala Ser Arg Glu Glu Ile His Glu Tyr Arg Arg Gln Leu Gln 
305                 310                 315                 320 


Ala Arg Thr Ile Glu Ile Glu Gly Leu Arg Gly Ala Asn Glu Ser Leu 
                325                 330                 335     


Glu Arg Gln Ile Leu Glu Leu Glu Glu Arg His Ser Ala Glu Val Ala 
            340                 345                 350         


Gly Tyr Gln Asp Ser Ile Gly Gln Leu Glu Asn Asp Leu Arg Asn Thr 
        355                 360                 365             


Lys Ser Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp Leu Leu Asn 
    370                 375                 380                 


Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu 
385                 390                 395                 400 


Glu Gly Glu Glu Thr Arg Phe Ser Thr Ser Gly Leu Ser Ile Ser Gly 
                405                 410                 415     


Leu Asn Pro Leu Pro Asn Pro Ser Tyr Leu Leu Pro Pro Arg Ile Leu 
            420                 425                 430         


Ser Ala Thr Thr Ser Lys Val Ser Ser Thr Gly Leu Ser Leu Lys Lys 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Ala Ser Lys Val Ala Ser Lys Lys Thr Ser 
    450                 455                 460                 


Gln Ile Gly Glu Ser Phe Glu Glu Ile Leu Glu Glu Thr Val Ile Ser 
465                 470                 475                 480 


Thr Lys Lys Thr Glu Lys Ser Asn Ile Glu Glu Thr Thr Ile Ser Ser 
                485                 490                 495     


Gln Lys Ile 
            


<210>  5496
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INCENP__Homo_sapiens__NP_001035784

<400>  5496

Met Gly Thr Thr Ala Pro Gly Pro Ile His Leu Leu Glu Leu Cys Asp 
1               5                   10                  15      


Gln Lys Leu Met Glu Phe Leu Cys Asn Met Asp Asn Lys Asp Leu Val 
            20                  25                  30          


Trp Leu Glu Glu Ile Gln Glu Glu Ala Glu Arg Met Phe Thr Arg Glu 
        35                  40                  45              


Phe Ser Lys Glu Pro Glu Leu Met Pro Lys Thr Pro Ser Gln Lys Asn 
    50                  55                  60                  


Arg Arg Lys Lys Arg Arg Ile Ser Tyr Val Gln Asp Glu Asn Arg Asp 
65                  70                  75                  80  


Pro Ile Arg Arg Arg Leu Ser Arg Arg Lys Ser Arg Ser Ser Gln Leu 
                85                  90                  95      


Ser Ser Arg Arg Leu Arg Ser Lys Asp Ser Val Glu Lys Leu Ala Thr 
            100                 105                 110         


Val Val Gly Glu Asn Gly Ser Val Leu Arg Arg Val Thr Arg Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Thr Met Ala Leu Ala Ala Pro Ser Ser Pro 
    130                 135                 140                 


Thr Pro Glu Ser Pro Thr Met Leu Thr Lys Lys Pro Glu Asp Asn His 
145                 150                 155                 160 


Thr Gln Cys Gln Leu Val Pro Val Val Glu Ile Gly Ile Ser Glu Arg 
                165                 170                 175     


Gln Asn Ala Glu Gln His Val Thr Gln Leu Met Ser Thr Glu Pro Leu 
            180                 185                 190         


Pro Arg Thr Leu Ser Pro Thr Pro Ala Ser Ala Thr Ala Pro Thr Ser 
        195                 200                 205             


Gln Gly Ile Pro Thr Ser Asp Glu Glu Ser Thr Pro Lys Lys Ser Lys 
    210                 215                 220                 


Ala Arg Ile Leu Glu Ser Ile Thr Val Ser Ser Leu Met Ala Thr Pro 
225                 230                 235                 240 


Gln Asp Pro Lys Gly Gln Gly Val Gly Thr Gly Arg Ser Ala Ser Lys 
                245                 250                 255     


Leu Arg Ile Ala Gln Val Ser Pro Gly Pro Arg Asp Ser Pro Ala Phe 
            260                 265                 270         


Pro Asp Ser Pro Trp Arg Glu Arg Val Leu Ala Pro Ile Leu Pro Asp 
        275                 280                 285             


Asn Phe Ser Thr Pro Thr Gly Ser Arg Thr Asp Ser Gln Ser Val Arg 
    290                 295                 300                 


His Ser Pro Ile Ala Pro Ser Ser Pro Ser Pro Gln Val Leu Ala Gln 
305                 310                 315                 320 


Lys Tyr Ser Leu Val Ala Lys Gln Glu Ser Val Val Arg Arg Ala Ser 
                325                 330                 335     


Arg Arg Leu Ala Lys Lys Thr Ala Glu Glu Pro Ala Ala Ser Gly Arg 
            340                 345                 350         


Ile Ile Cys His Ser Tyr Leu Glu Arg Leu Leu Asn Val Glu Val Pro 
        355                 360                 365             


Gln Lys Val Gly Ser Glu Gln Lys Glu Pro Pro Glu Glu Ala Glu Pro 
    370                 375                 380                 


Val Ala Ala Ala Glu Pro Glu Val Pro Glu Asn Asn Gly Asn Asn Ser 
385                 390                 395                 400 


Trp Pro His Asn Asp Thr Glu Ile Ala Asn Ser Thr Pro Asn Pro Lys 
                405                 410                 415     


Pro Ala Ala Ser Ser Pro Glu Thr Pro Ser Ala Gly Gln Gln Glu Ala 
            420                 425                 430         


Lys Thr Asp Gln Ala Asp Gly Pro Arg Glu Pro Pro Gln Ser Ala Arg 
        435                 440                 445             


Arg Lys Arg Ser Tyr Lys Gln Ala Val Ser Glu Leu Asp Glu Glu Gln 
    450                 455                 460                 


His Leu Glu Asp Glu Glu Leu Gln Pro Pro Arg Ser Lys Thr Pro Ser 
465                 470                 475                 480 


Ser Pro Cys Pro Ala Ser Lys Val Val Arg Pro Leu Arg Thr Phe Leu 
                485                 490                 495     


His Thr Val Gln Arg Asn Gln Met Leu Met Thr Pro Thr Ser Ala Pro 
            500                 505                 510         


Arg Ser Val Met Lys Ser Phe Ile Lys Arg Asn Thr Pro Leu Arg Met 
        515                 520                 525             


Asp Pro Lys Cys Ser Phe Val Glu Lys Glu Arg Gln Arg Leu Glu Asn 
    530                 535                 540                 


Leu Arg Arg Lys Glu Glu Ala Glu Gln Leu Arg Arg Gln Lys Val Glu 
545                 550                 555                 560 


Glu Asp Lys Arg Arg Arg Leu Glu Glu Val Lys Leu Lys Arg Glu Glu 
                565                 570                 575     


Arg Leu Arg Lys Val Leu Gln Ala Arg Glu Arg Val Glu Gln Met Lys 
            580                 585                 590         


Glu Glu Lys Lys Lys Gln Ile Glu Gln Lys Phe Ala Gln Ile Asp Glu 
        595                 600                 605             


Lys Thr Glu Lys Ala Lys Glu Glu Arg Leu Ala Glu Glu Lys Ala Lys 
    610                 615                 620                 


Lys Lys Ala Ala Ala Lys Lys Met Glu Glu Val Glu Ala Arg Arg Lys 
625                 630                 635                 640 


Gln Glu Glu Glu Ala Arg Arg Leu Arg Trp Leu Gln Gln Glu Glu Glu 
                645                 650                 655     


Glu Arg Arg His Gln Glu Leu Leu Gln Lys Lys Lys Glu Glu Glu Gln 
            660                 665                 670         


Glu Arg Leu Arg Lys Ala Ala Glu Ala Lys Arg Leu Ala Glu Gln Arg 
        675                 680                 685             


Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu 
    690                 695                 700                 


Gln Glu Arg Arg Glu Gln Glu Arg Arg Glu Gln Glu Arg Gln Leu Ala 
705                 710                 715                 720 


Glu Gln Glu Arg Arg Arg Glu Gln Glu Arg Leu Gln Ala Glu Arg Glu 
                725                 730                 735     


Leu Gln Glu Arg Glu Lys Ala Leu Arg Leu Gln Lys Glu Gln Leu Gln 
            740                 745                 750         


Arg Glu Leu Glu Glu Lys Lys Lys Lys Glu Glu Gln Gln Arg Leu Ala 
        755                 760                 765             


Glu Arg Gln Leu Gln Glu Glu Gln Glu Lys Lys Ala Lys Glu Ala Ala 
    770                 775                 780                 


Gly Ala Ser Lys Ala Leu Asn Val Thr Val Asp Val Gln Ser Pro Ala 
785                 790                 795                 800 


Cys Thr Ser Tyr Gln Met Thr Pro Gln Gly His Arg Ala Pro Pro Lys 
                805                 810                 815     


Ile Asn Pro Asp Asn Tyr Gly Met Asp Leu Asn Ser Asp Asp Ser Thr 
            820                 825                 830         


Asp Asp Glu Ala His Pro Arg Lys Pro Ile Pro Thr Trp Ala Arg Gly 
        835                 840                 845             


Thr Pro Leu Ser Gln Ala Ile Ile His Gln Tyr Tyr His Pro Pro Asn 
    850                 855                 860                 


Leu Leu Glu Leu Phe Gly Thr Ile Leu Pro Leu Asp Leu Glu Asp Ile 
865                 870                 875                 880 


Phe Lys Lys Ser Lys Pro Arg Tyr His Lys Arg Thr Ser Ser Ala Val 
                885                 890                 895     


Trp Asn Ser Pro Pro Leu Gln Gly Ala Arg Val Pro Ser Ser Leu Ala 
            900                 905                 910         


Tyr Ser Leu Lys Lys His 
        915             


<210>  5497
<211>  1240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INF2__Homo_sapiens__NP_001026884

<400>  5497

Met Ser Val Lys Glu Gly Ala Gln Arg Lys Trp Ala Ala Leu Lys Glu 
1               5                   10                  15      


Lys Leu Gly Pro Gln Asp Ser Asp Pro Thr Glu Ala Asn Leu Glu Ser 
            20                  25                  30          


Ala Asp Pro Glu Leu Cys Ile Arg Leu Leu Gln Met Pro Ser Val Val 
        35                  40                  45              


Asn Tyr Ser Gly Leu Arg Lys Arg Leu Glu Gly Ser Asp Gly Gly Trp 
    50                  55                  60                  


Met Val Gln Phe Leu Glu Gln Ser Gly Leu Asp Leu Leu Leu Glu Ala 
65                  70                  75                  80  


Leu Ala Arg Leu Ser Gly Arg Gly Val Ala Arg Ile Ser Asp Ala Leu 
                85                  90                  95      


Leu Gln Leu Thr Cys Val Ser Cys Val Arg Ala Val Met Asn Ser Arg 
            100                 105                 110         


Gln Gly Ile Glu Tyr Ile Leu Ser Asn Gln Gly Tyr Val Arg Gln Leu 
        115                 120                 125             


Ser Gln Ala Leu Asp Thr Ser Asn Val Met Val Lys Lys Gln Val Phe 
    130                 135                 140                 


Glu Leu Leu Ala Ala Leu Cys Ile Tyr Ser Pro Glu Gly His Val Leu 
145                 150                 155                 160 


Thr Leu Asp Ala Leu Asp His Tyr Lys Thr Val Cys Ser Gln Gln Tyr 
                165                 170                 175     


Arg Phe Ser Ile Val Met Asn Glu Leu Ser Gly Ser Asp Asn Val Pro 
            180                 185                 190         


Tyr Val Val Thr Leu Leu Ser Val Ile Asn Ala Val Ile Leu Gly Pro 
        195                 200                 205             


Glu Asp Leu Arg Ala Arg Thr Gln Leu Arg Asn Glu Phe Ile Gly Leu 
    210                 215                 220                 


Gln Leu Leu Asp Val Leu Ala Arg Leu Arg Asp Leu Glu Asp Ala Asp 
225                 230                 235                 240 


Leu Leu Ile Gln Leu Glu Ala Phe Glu Glu Ala Lys Ala Glu Asp Glu 
                245                 250                 255     


Glu Glu Leu Leu Arg Val Ser Gly Gly Val Asp Met Ser Ser His Gln 
            260                 265                 270         


Glu Val Phe Ala Ser Leu Phe His Lys Val Ser Cys Ser Pro Val Ser 
        275                 280                 285             


Ala Gln Leu Leu Ser Val Leu Gln Gly Leu Leu His Leu Glu Pro Thr 
    290                 295                 300                 


Leu Arg Ser Ser Gln Leu Leu Trp Glu Ala Leu Glu Ser Leu Val Asn 
305                 310                 315                 320 


Arg Ala Val Leu Leu Ala Ser Asp Ala Gln Glu Cys Thr Leu Glu Glu 
                325                 330                 335     


Val Val Glu Arg Leu Leu Ser Val Lys Gly Arg Pro Arg Pro Ser Pro 
            340                 345                 350         


Leu Val Lys Ala His Lys Ser Val Gln Ala Asn Leu Asp Gln Ser Gln 
        355                 360                 365             


Arg Gly Ser Ser Pro Gln Asn Thr Thr Thr Pro Lys Pro Ser Val Glu 
    370                 375                 380                 


Gly Gln Gln Pro Ala Ala Ala Ala Ala Cys Glu Pro Val Asp His Ala 
385                 390                 395                 400 


Gln Ser Glu Ser Ile Leu Lys Val Ser Gln Pro Arg Ala Leu Glu Gln 
                405                 410                 415     


Gln Ala Ser Thr Pro Pro Pro Pro Pro Pro Pro Pro Leu Leu Pro Gly 
            420                 425                 430         


Ser Ser Ala Glu Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser 
        435                 440                 445             


Val Gly Ala Lys Ala Leu Pro Thr Ala Pro Pro Pro Pro Pro Leu Pro 
    450                 455                 460                 


Gly Leu Gly Ala Met Ala Pro Pro Ala Pro Pro Leu Pro Pro Pro Leu 
465                 470                 475                 480 


Pro Gly Ser Cys Glu Phe Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly 
                485                 490                 495     


Leu Gly Cys Pro Pro Pro Pro Pro Pro Leu Leu Pro Gly Met Gly Trp 
            500                 505                 510         


Gly Pro Pro Pro Pro Pro Pro Pro Leu Leu Pro Cys Thr Cys Ser Pro 
        515                 520                 525             


Pro Val Ala Gly Gly Met Glu Glu Val Ile Val Ala Gln Val Asp His 
    530                 535                 540                 


Gly Leu Gly Ser Ala Trp Val Pro Ser His Arg Arg Val Asn Pro Pro 
545                 550                 555                 560 


Thr Leu Arg Met Lys Lys Leu Asn Trp Gln Lys Leu Pro Ser Asn Val 
                565                 570                 575     


Ala Arg Glu His Asn Ser Met Trp Ala Ser Leu Ser Ser Pro Asp Ala 
            580                 585                 590         


Glu Ala Val Glu Pro Asp Phe Ser Ser Ile Glu Arg Leu Phe Ser Phe 
        595                 600                 605             


Pro Ala Ala Lys Pro Lys Glu Pro Thr Met Val Ala Pro Arg Ala Arg 
    610                 615                 620                 


Lys Glu Pro Lys Glu Ile Thr Phe Leu Asp Ala Lys Lys Ser Leu Asn 
625                 630                 635                 640 


Leu Asn Ile Phe Leu Lys Gln Phe Lys Cys Ser Asn Glu Glu Val Ala 
                645                 650                 655     


Ala Met Ile Arg Ala Gly Asp Thr Thr Lys Phe Asp Val Glu Val Leu 
            660                 665                 670         


Lys Gln Leu Leu Lys Leu Leu Pro Glu Lys His Glu Ile Glu Asn Leu 
        675                 680                 685             


Arg Ala Phe Thr Glu Glu Arg Ala Lys Leu Ala Ser Ala Asp His Phe 
    690                 695                 700                 


Tyr Leu Leu Leu Leu Ala Ile Pro Cys Tyr Gln Leu Arg Ile Glu Cys 
705                 710                 715                 720 


Met Leu Leu Cys Glu Gly Ala Ala Ala Val Leu Asp Met Val Arg Pro 
                725                 730                 735     


Lys Ala Gln Leu Val Leu Ala Ala Cys Glu Ser Leu Leu Thr Ser Arg 
            740                 745                 750         


Gln Leu Pro Ile Phe Cys Gln Leu Ile Leu Arg Ile Gly Asn Phe Leu 
        755                 760                 765             


Asn Tyr Gly Ser His Thr Gly Asp Ala Asp Gly Phe Lys Ile Ser Thr 
    770                 775                 780                 


Leu Leu Lys Leu Thr Glu Thr Lys Ser Gln Gln Asn Arg Val Thr Leu 
785                 790                 795                 800 


Leu His His Val Leu Glu Glu Ala Glu Lys Ser His Pro Asp Leu Leu 
                805                 810                 815     


Gln Leu Pro Arg Asp Leu Glu Gln Pro Ser Gln Ala Ala Gly Ile Asn 
            820                 825                 830         


Leu Glu Ile Ile Arg Ser Glu Ala Ser Ser Asn Leu Lys Lys Leu Leu 
        835                 840                 845             


Glu Thr Glu Arg Lys Val Ser Ala Ser Val Ala Glu Val Gln Glu Gln 
    850                 855                 860                 


Tyr Thr Glu Arg Leu Gln Ala Ser Ile Ser Ala Phe Arg Ala Leu Asp 
865                 870                 875                 880 


Glu Leu Phe Glu Ala Ile Glu Gln Lys Gln Arg Glu Leu Ala Asp Tyr 
                885                 890                 895     


Leu Cys Glu Asp Ala Gln Gln Leu Ser Leu Glu Asp Thr Phe Ser Thr 
            900                 905                 910         


Met Lys Ala Phe Arg Asp Leu Phe Leu Arg Ala Leu Lys Glu Asn Lys 
        915                 920                 925             


Asp Arg Lys Glu Gln Ala Ala Lys Ala Glu Arg Arg Lys Gln Gln Leu 
    930                 935                 940                 


Ala Glu Glu Glu Ala Arg Arg Pro Arg Gly Glu Asp Gly Lys Pro Val 
945                 950                 955                 960 


Arg Lys Gly Pro Gly Lys Gln Glu Glu Val Cys Val Ile Asp Ala Leu 
                965                 970                 975     


Leu Ala Asp Ile Arg Lys Gly Phe Gln Leu Arg Lys Thr Ala Arg Gly 
            980                 985                 990         


Arg Gly Asp Thr Asp Gly Gly Ser  Lys Ala Ala Ser Met  Asp Pro Pro 
        995                 1000                 1005             


Arg Ala  Thr Glu Pro Val Ala  Thr Ser Asn Pro Ala  Gly Asp Pro 
    1010                 1015                 1020             


Val Gly  Ser Thr Arg Cys Pro  Ala Ser Glu Pro Gly  Leu Asp Ala 
    1025                 1030                 1035             


Thr Thr  Ala Ser Glu Ser Arg  Gly Trp Asp Leu Val  Asp Ala Val 
    1040                 1045                 1050             


Thr Pro  Gly Pro Gln Pro Thr  Leu Glu Gln Leu Glu  Glu Gly Gly 
    1055                 1060                 1065             


Pro Arg  Pro Leu Glu Arg Arg  Ser Ser Trp Tyr Val  Asp Ala Ser 
    1070                 1075                 1080             


Asp Val  Leu Thr Thr Glu Asp  Pro Gln Cys Pro Gln  Pro Leu Glu 
    1085                 1090                 1095             


Gly Ala  Trp Pro Val Thr Leu  Gly Asp Ala Gln Ala  Leu Lys Pro 
    1100                 1105                 1110             


Leu Lys  Phe Ser Ser Asn Gln  Pro Pro Ala Ala Gly  Ser Ser Arg 
    1115                 1120                 1125             


Gln Asp  Ala Lys Asp Pro Thr  Ser Leu Leu Gly Val  Leu Gln Ala 
    1130                 1135                 1140             


Glu Ala  Asp Ser Thr Ser Glu  Gly Leu Glu Asp Ala  Val His Ser 
    1145                 1150                 1155             


Arg Gly  Ala Arg Pro Pro Ala  Ala Gly Pro Gly Gly  Asp Glu Asp 
    1160                 1165                 1170             


Glu Asp  Glu Glu Asp Thr Ala  Pro Glu Ser Ala Leu  Asp Thr Ser 
    1175                 1180                 1185             


Leu Asp  Lys Ser Phe Ser Glu  Asp Ala Val Thr Asp  Ser Ser Gly 
    1190                 1195                 1200             


Ser Gly  Thr Leu Pro Arg Ala  Arg Gly Arg Ala Ser  Lys Gly Thr 
    1205                 1210                 1215             


Gly Lys  Arg Arg Lys Lys Arg  Pro Ser Arg Ser Gln  Glu Gly Leu 
    1220                 1225                 1230             


Arg Pro  Arg Pro Lys Ala Lys  
    1235                 1240 


<210>  5498
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ING1__Homo_sapiens__NP_001254657

<400>  5498

Met Ser Phe Val Glu Cys Pro Tyr His Ser Pro Ala Glu Arg Leu Val 
1               5                   10                  15      


Ala Glu Ala Asp Glu Gly Gly Pro Ser Ala Ile Thr Glu Ile Leu Lys 
            20                  25                  30          


Glu Leu Asp Glu Cys Tyr Glu Arg Phe Ser Arg Glu Thr Asp Gly Ala 
        35                  40                  45              


Gln Lys Arg Arg Met Leu His Cys Val Gln Arg Ala Leu Ile Arg Ser 
    50                  55                  60                  


Gln Glu Leu Gly Asp Glu Lys Ile Gln Ile Val Ser Gln Met Val Glu 
65                  70                  75                  80  


Leu Val Glu Asn Arg Thr Arg Gln Val Asp Ser His Val Glu Leu Phe 
                85                  90                  95      


Glu Ala Gln Gln Glu Leu Gly Asp Thr Ala Gly Asn Ser Gly Lys Ala 
            100                 105                 110         


Gly Ala Asp Arg Pro Lys Gly Glu Ala Ala Ala Gln Ala Asp Lys Pro 
        115                 120                 125             


Asn Ser Lys Arg Ser Arg Arg Gln Arg Asn Asn Glu Asn Arg Glu Asn 
    130                 135                 140                 


Ala Ser Ser Asn His Asp His Asp Asp Gly Ala Ser Gly Thr Pro Lys 
145                 150                 155                 160 


Glu Lys Lys Ala Lys Thr Ser Lys Lys Lys Lys Arg Ser Lys Ala Lys 
                165                 170                 175     


Ala Glu Arg Glu Ala Ser Pro Ala Asp Leu Pro Ile Asp Pro Asn Glu 
            180                 185                 190         


Pro Thr Tyr Cys Leu Cys Asn Gln Val Ser Tyr Gly Glu Met Ile Gly 
        195                 200                 205             


Cys Asp Asn Asp Glu Cys Pro Ile Glu Trp Phe His Phe Ser Cys Val 
    210                 215                 220                 


Gly Leu Asn His Lys Pro Lys Gly Lys Trp Tyr Cys Pro Lys Cys Arg 
225                 230                 235                 240 


Gly Glu Asn Glu Lys Thr Met Asp Lys Ala Leu Glu Lys Ser Lys Lys 
                245                 250                 255     


Glu Arg Ala Tyr Asn Arg 
            260         


<210>  5499
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ING2__Homo_sapiens__NP_001278888

<400>  5499

Met Asp Gln Asp Gly Asp Gln Gln Leu Gly Pro Ser Arg Ile Leu Ala 
1               5                   10                  15      


Pro Gln Thr Leu Lys Glu Ile Asp Asp Val Tyr Glu Lys Tyr Lys Lys 
            20                  25                  30          


Glu Asp Asp Leu Asn Gln Lys Lys Arg Leu Gln Gln Leu Leu Gln Arg 
        35                  40                  45              


Ala Leu Ile Asn Ser Gln Glu Leu Gly Asp Glu Lys Ile Gln Ile Val 
    50                  55                  60                  


Thr Gln Met Leu Glu Leu Val Glu Asn Arg Ala Arg Gln Met Glu Leu 
65                  70                  75                  80  


His Ser Gln Cys Phe Gln Asp Pro Ala Glu Ser Glu Arg Ala Ser Asp 
                85                  90                  95      


Lys Ala Lys Met Asp Ser Ser Gln Pro Glu Arg Ser Ser Arg Arg Pro 
            100                 105                 110         


Arg Arg Gln Arg Thr Ser Glu Ser Arg Asp Leu Cys His Met Ala Asn 
        115                 120                 125             


Gly Ile Glu Asp Cys Asp Asp Gln Pro Pro Lys Glu Lys Lys Ser Lys 
    130                 135                 140                 


Ser Ala Lys Lys Lys Lys Arg Ser Lys Ala Lys Gln Glu Arg Glu Ala 
145                 150                 155                 160 


Ser Pro Val Glu Phe Ala Ile Asp Pro Asn Glu Pro Thr Tyr Cys Leu 
                165                 170                 175     


Cys Asn Gln Val Ser Tyr Gly Glu Met Ile Gly Cys Asp Asn Glu Gln 
            180                 185                 190         


Cys Pro Ile Glu Trp Phe His Phe Ser Cys Val Ser Leu Thr Tyr Lys 
        195                 200                 205             


Pro Lys Gly Lys Trp Tyr Cys Pro Lys Cys Arg Gly Asp Asn Glu Lys 
    210                 215                 220                 


Thr Met Asp Lys Ser Thr Glu Lys Thr Lys Lys Asp Arg Arg Ser Arg 
225                 230                 235                 240 


<210>  5500
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ING3__Homo_sapiens__NP_061944

<400>  5500

Met Leu Tyr Leu Glu Asp Tyr Leu Glu Met Ile Glu Gln Leu Pro Met 
1               5                   10                  15      


Asp Leu Arg Asp Arg Phe Thr Glu Met Arg Glu Met Asp Leu Gln Val 
            20                  25                  30          


Gln Asn Ala Met Asp Gln Leu Glu Gln Arg Val Ser Glu Phe Phe Met 
        35                  40                  45              


Asn Ala Lys Lys Asn Lys Pro Glu Trp Arg Glu Glu Gln Met Ala Ser 
    50                  55                  60                  


Ile Lys Lys Asp Tyr Tyr Lys Ala Leu Glu Asp Ala Asp Glu Lys Val 
65                  70                  75                  80  


Gln Leu Ala Asn Gln Ile Tyr Asp Leu Val Asp Arg His Leu Arg Lys 
                85                  90                  95      


Leu Asp Gln Glu Leu Ala Lys Phe Lys Met Glu Leu Glu Ala Asp Asn 
            100                 105                 110         


Ala Gly Ile Thr Glu Ile Leu Glu Arg Arg Ser Leu Glu Leu Asp Thr 
        115                 120                 125             


Pro Ser Gln Pro Val Asn Asn His His Ala His Ser His Thr Pro Val 
    130                 135                 140                 


Glu Lys Arg Lys Tyr Asn Pro Thr Ser His His Thr Thr Thr Asp His 
145                 150                 155                 160 


Ile Pro Glu Lys Lys Phe Lys Ser Glu Ala Leu Leu Ser Thr Leu Thr 
                165                 170                 175     


Ser Asp Ala Ser Lys Glu Asn Thr Leu Gly Cys Arg Asn Asn Asn Ser 
            180                 185                 190         


Thr Ala Ser Ser Asn Asn Ala Tyr Asn Val Asn Ser Ser Gln Pro Leu 
        195                 200                 205             


Gly Ser Tyr Asn Ile Gly Ser Leu Ser Ser Gly Thr Gly Ala Gly Ala 
    210                 215                 220                 


Ile Thr Met Ala Ala Ala Gln Ala Val Gln Ala Thr Ala Gln Met Lys 
225                 230                 235                 240 


Glu Gly Arg Arg Thr Ser Ser Leu Lys Ala Ser Tyr Glu Ala Phe Lys 
                245                 250                 255     


Asn Asn Asp Phe Gln Leu Gly Lys Glu Phe Ser Met Ala Arg Glu Thr 
            260                 265                 270         


Val Gly Tyr Ser Ser Ser Ser Ala Leu Met Thr Thr Leu Thr Gln Asn 
        275                 280                 285             


Ala Ser Ser Ser Ala Ala Asp Ser Arg Ser Gly Arg Lys Ser Lys Asn 
    290                 295                 300                 


Asn Asn Lys Ser Ser Ser Gln Gln Ser Ser Ser Ser Ser Ser Ser Ser 
305                 310                 315                 320 


Ser Leu Ser Ser Cys Ser Ser Ser Ser Thr Val Val Gln Glu Ile Ser 
                325                 330                 335     


Gln Gln Thr Thr Val Val Pro Glu Ser Asp Ser Asn Ser Gln Val Asp 
            340                 345                 350         


Trp Thr Tyr Asp Pro Asn Glu Pro Arg Tyr Cys Ile Cys Asn Gln Val 
        355                 360                 365             


Ser Tyr Gly Glu Met Val Gly Cys Asp Asn Gln Asp Cys Pro Ile Glu 
    370                 375                 380                 


Trp Phe His Tyr Gly Cys Val Gly Leu Thr Glu Ala Pro Lys Gly Lys 
385                 390                 395                 400 


Trp Tyr Cys Pro Gln Cys Thr Ala Ala Met Lys Arg Arg Gly Ser Arg 
                405                 410                 415     


His Lys 
        


<210>  5501
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ING4__Homo_sapiens__NP_001121054

<400>  5501

Met Ala Ala Gly Met Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 
1               5                   10                  15      


Leu Pro Phe Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp 
            20                  25                  30          


Gln Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 
        35                  40                  45              


Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu 
    50                  55                  60                  


Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met Val Asp Lys His 
                85                  90                  95      


Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg Phe Glu Ala Asp Leu Lys 
            100                 105                 110         


Glu Lys Gln Ile Glu Ser Ser Asp Tyr Asp Ser Ser Ser Ser Lys Gly 
        115                 120                 125             


Lys Lys Lys Gly Arg Thr Gln Lys Glu Lys Lys Ala Ala Arg Ala Arg 
    130                 135                 140                 


Ser Lys Gly Lys Asn Ser Asp Glu Glu Ala Pro Lys Thr Ala Gln Lys 
145                 150                 155                 160 


Lys Leu Lys Leu Val Arg Thr Ser Pro Glu Tyr Gly Met Pro Ser Val 
                165                 170                 175     


Thr Phe Gly Ser Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp 
            180                 185                 190         


Pro Asn Glu Pro Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly Glu 
        195                 200                 205             


Met Ile Gly Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp Phe His Phe 
    210                 215                 220                 


Ala Cys Val Gly Leu Thr Thr Lys Pro Arg Gly Lys Trp Phe Cys Pro 
225                 230                 235                 240 


Arg Cys Ser Gln Glu Arg Lys Lys Lys 
                245                 


<210>  5502
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ING5__Homo_sapiens__NP_115705

<400>  5502

Met Ala Thr Ala Met Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 
1               5                   10                  15      


Leu Pro Cys Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Glu Leu Asp 
            20                  25                  30          


Gln Arg Thr Glu Asp Lys Lys Ala Glu Ile Asp Ile Leu Ala Ala Glu 
        35                  40                  45              


Tyr Ile Ser Thr Val Lys Thr Leu Ser Pro Asp Gln Arg Val Glu Arg 
    50                  55                  60                  


Leu Gln Lys Ile Gln Asn Ala Tyr Ser Lys Cys Lys Glu Tyr Ser Asp 
65                  70                  75                  80  


Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met Val Asp Lys His 
                85                  90                  95      


Ile Arg Arg Leu Asp Ala Asp Leu Ala Arg Phe Glu Ala Asp Leu Lys 
            100                 105                 110         


Asp Lys Met Glu Gly Ser Asp Phe Glu Ser Ser Gly Gly Arg Gly Leu 
        115                 120                 125             


Lys Lys Gly Arg Gly Gln Lys Glu Lys Arg Gly Ser Arg Gly Arg Gly 
    130                 135                 140                 


Arg Arg Thr Ser Glu Glu Asp Thr Pro Lys Lys Lys Lys His Lys Gly 
145                 150                 155                 160 


Gly Ser Glu Phe Thr Asp Thr Ile Leu Ser Val His Pro Ser Asp Val 
                165                 170                 175     


Leu Asp Met Pro Val Asp Pro Asn Glu Pro Thr Tyr Cys Leu Cys His 
            180                 185                 190         


Gln Val Ser Tyr Gly Glu Met Ile Gly Cys Asp Asn Pro Asp Cys Pro 
        195                 200                 205             


Ile Glu Trp Phe His Phe Ala Cys Val Asp Leu Thr Thr Lys Pro Lys 
    210                 215                 220                 


Gly Lys Trp Phe Cys Pro Arg Cys Val Gln Glu Lys Arg Lys Lys Lys 
225                 230                 235                 240 


<210>  5503
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INHA__Homo_sapiens__NP_002182

<400>  5503

Met Val Leu His Leu Leu Leu Phe Leu Leu Leu Thr Pro Gln Gly Gly 
1               5                   10                  15      


His Ser Cys Gln Gly Leu Glu Leu Ala Arg Glu Leu Val Leu Ala Lys 
            20                  25                  30          


Val Arg Ala Leu Phe Leu Asp Ala Leu Gly Pro Pro Ala Val Thr Arg 
        35                  40                  45              


Glu Gly Gly Asp Pro Gly Val Arg Arg Leu Pro Arg Arg His Ala Leu 
    50                  55                  60                  


Gly Gly Phe Thr His Arg Gly Ser Glu Pro Glu Glu Glu Glu Asp Val 
65                  70                  75                  80  


Ser Gln Ala Ile Leu Phe Pro Ala Thr Asp Ala Ser Cys Glu Asp Lys 
                85                  90                  95      


Ser Ala Ala Arg Gly Leu Ala Gln Glu Ala Glu Glu Gly Leu Phe Arg 
            100                 105                 110         


Tyr Met Phe Arg Pro Ser Gln His Thr Arg Ser Arg Gln Val Thr Ser 
        115                 120                 125             


Ala Gln Leu Trp Phe His Thr Gly Leu Asp Arg Gln Gly Thr Ala Ala 
    130                 135                 140                 


Ser Asn Ser Ser Glu Pro Leu Leu Gly Leu Leu Ala Leu Ser Pro Gly 
145                 150                 155                 160 


Gly Pro Val Ala Val Pro Met Ser Leu Gly His Ala Pro Pro His Trp 
                165                 170                 175     


Ala Val Leu His Leu Ala Thr Ser Ala Leu Ser Leu Leu Thr His Pro 
            180                 185                 190         


Val Leu Val Leu Leu Leu Arg Cys Pro Leu Cys Thr Cys Ser Ala Arg 
        195                 200                 205             


Pro Glu Ala Thr Pro Phe Leu Val Ala His Thr Arg Thr Arg Pro Pro 
    210                 215                 220                 


Ser Gly Gly Glu Arg Ala Arg Arg Ser Thr Pro Leu Met Ser Trp Pro 
225                 230                 235                 240 


Trp Ser Pro Ser Ala Leu Arg Leu Leu Gln Arg Pro Pro Glu Glu Pro 
                245                 250                 255     


Ala Ala His Ala Asn Cys His Arg Val Ala Leu Asn Ile Ser Phe Gln 
            260                 265                 270         


Glu Leu Gly Trp Glu Arg Trp Ile Val Tyr Pro Pro Ser Phe Ile Phe 
        275                 280                 285             


His Tyr Cys His Gly Gly Cys Gly Leu His Ile Pro Pro Asn Leu Ser 
    290                 295                 300                 


Leu Pro Val Pro Gly Ala Pro Pro Thr Pro Ala Gln Pro Tyr Ser Leu 
305                 310                 315                 320 


Leu Pro Gly Ala Gln Pro Cys Cys Ala Ala Leu Pro Gly Thr Met Arg 
                325                 330                 335     


Pro Leu His Val Arg Thr Thr Ser Asp Gly Gly Tyr Ser Phe Lys Tyr 
            340                 345                 350         


Glu Thr Val Pro Asn Leu Leu Thr Gln His Cys Ala Cys Ile 
        355                 360                 365     


<210>  5504
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INHBA__Homo_sapiens__NP_002183

<400>  5504

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  5505
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INHBB__Homo_sapiens__NP_002184

<400>  5505

Met Asp Gly Leu Pro Gly Arg Ala Leu Gly Ala Ala Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Gly Trp Leu Gly Pro Glu Ala Trp Gly Ser Pro Thr Pro 
            20                  25                  30          


Pro Pro Thr Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ser Pro 
        35                  40                  45              


Gly Gly Ser Gln Asp Thr Cys Thr Ser Cys Gly Gly Phe Arg Arg Pro 
    50                  55                  60                  


Glu Glu Leu Gly Arg Val Asp Gly Asp Phe Leu Glu Ala Val Lys Arg 
65                  70                  75                  80  


His Ile Leu Ser Arg Leu Gln Met Arg Gly Arg Pro Asn Ile Thr His 
                85                  90                  95      


Ala Val Pro Lys Ala Ala Met Val Thr Ala Leu Arg Lys Leu His Ala 
            100                 105                 110         


Gly Lys Val Arg Glu Asp Gly Arg Val Glu Ile Pro His Leu Asp Gly 
        115                 120                 125             


His Ala Ser Pro Gly Ala Asp Gly Gln Glu Arg Val Ser Glu Ile Ile 
    130                 135                 140                 


Ser Phe Ala Glu Thr Asp Gly Leu Ala Ser Ser Arg Val Arg Leu Tyr 
145                 150                 155                 160 


Phe Phe Ile Ser Asn Glu Gly Asn Gln Asn Leu Phe Val Val Gln Ala 
                165                 170                 175     


Ser Leu Trp Leu Tyr Leu Lys Leu Leu Pro Tyr Val Leu Glu Lys Gly 
            180                 185                 190         


Ser Arg Arg Lys Val Arg Val Lys Val Tyr Phe Gln Glu Gln Gly His 
        195                 200                 205             


Gly Asp Arg Trp Asn Met Val Glu Lys Arg Val Asp Leu Lys Arg Ser 
    210                 215                 220                 


Gly Trp His Thr Phe Pro Leu Thr Glu Ala Ile Gln Ala Leu Phe Glu 
225                 230                 235                 240 


Arg Gly Glu Arg Arg Leu Asn Leu Asp Val Gln Cys Asp Ser Cys Gln 
                245                 250                 255     


Glu Leu Ala Val Val Pro Val Phe Val Asp Pro Gly Glu Glu Ser His 
            260                 265                 270         


Arg Pro Phe Val Val Val Gln Ala Arg Leu Gly Asp Ser Arg His Arg 
        275                 280                 285             


Ile Arg Lys Arg Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys 
    290                 295                 300                 


Arg Gln Gln Phe Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp 
305                 310                 315                 320 


Ile Ile Ala Pro Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys 
                325                 330                 335     


Pro Ala Tyr Leu Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr 
            340                 345                 350         


Ala Val Val Asn Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val 
        355                 360                 365             


Asn Ser Cys Cys Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr 
    370                 375                 380                 


Phe Asp Asp Glu Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile 
385                 390                 395                 400 


Val Glu Glu Cys Gly Cys Ala 
                405         


<210>  5506
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INHBC__Homo_sapiens__NP_005529

<400>  5506

Met Thr Ser Ser Leu Leu Leu Ala Phe Leu Leu Leu Ala Pro Thr Thr 
1               5                   10                  15      


Val Ala Thr Pro Arg Ala Gly Gly Gln Cys Pro Ala Cys Gly Gly Pro 
            20                  25                  30          


Thr Leu Glu Leu Glu Ser Gln Arg Glu Leu Leu Leu Asp Leu Ala Lys 
        35                  40                  45              


Arg Ser Ile Leu Asp Lys Leu His Leu Thr Gln Arg Pro Thr Leu Asn 
    50                  55                  60                  


Arg Pro Val Ser Arg Ala Ala Leu Arg Thr Ala Leu Gln His Leu His 
65                  70                  75                  80  


Gly Val Pro Gln Gly Ala Leu Leu Glu Asp Asn Arg Glu Gln Glu Cys 
                85                  90                  95      


Glu Ile Ile Ser Phe Ala Glu Thr Gly Leu Ser Thr Ile Asn Gln Thr 
            100                 105                 110         


Arg Leu Asp Phe His Phe Ser Ser Asp Arg Thr Ala Gly Asp Arg Glu 
        115                 120                 125             


Val Gln Gln Ala Ser Leu Met Phe Phe Val Gln Leu Pro Ser Asn Thr 
    130                 135                 140                 


Thr Trp Thr Leu Lys Val Arg Val Leu Val Leu Gly Pro His Asn Thr 
145                 150                 155                 160 


Asn Leu Thr Leu Ala Thr Gln Tyr Leu Leu Glu Val Asp Ala Ser Gly 
                165                 170                 175     


Trp His Gln Leu Pro Leu Gly Pro Glu Ala Gln Ala Ala Cys Ser Gln 
            180                 185                 190         


Gly His Leu Thr Leu Glu Leu Val Leu Glu Gly Gln Val Ala Gln Ser 
        195                 200                 205             


Ser Val Ile Leu Gly Gly Ala Ala His Arg Pro Phe Val Ala Ala Arg 
    210                 215                 220                 


Val Arg Val Gly Gly Lys His Gln Ile His Arg Arg Gly Ile Asp Cys 
225                 230                 235                 240 


Gln Gly Gly Ser Arg Met Cys Cys Arg Gln Glu Phe Phe Val Asp Phe 
                245                 250                 255     


Arg Glu Ile Gly Trp His Asp Trp Ile Ile Gln Pro Glu Gly Tyr Ala 
            260                 265                 270         


Met Asn Phe Cys Ile Gly Gln Cys Pro Leu His Ile Ala Gly Met Pro 
        275                 280                 285             


Gly Ile Ala Ala Ser Phe His Thr Ala Val Leu Asn Leu Leu Lys Ala 
    290                 295                 300                 


Asn Thr Ala Ala Gly Thr Thr Gly Gly Gly Ser Cys Cys Val Pro Thr 
305                 310                 315                 320 


Ala Arg Arg Pro Leu Ser Leu Leu Tyr Tyr Asp Arg Asp Ser Asn Ile 
                325                 330                 335     


Val Lys Thr Asp Ile Pro Asp Met Val Val Glu Ala Cys Gly Cys Ser 
            340                 345                 350         


<210>  5507
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INHBE__Homo_sapiens__NP_113667

<400>  5507

Met Arg Leu Pro Asp Val Gln Leu Trp Leu Val Leu Leu Trp Ala Leu 
1               5                   10                  15      


Val Arg Ala Gln Gly Thr Gly Ser Val Cys Pro Ser Cys Gly Gly Ser 
            20                  25                  30          


Lys Leu Ala Pro Gln Ala Glu Arg Ala Leu Val Leu Glu Leu Ala Lys 
        35                  40                  45              


Gln Gln Ile Leu Asp Gly Leu His Leu Thr Ser Arg Pro Arg Ile Thr 
    50                  55                  60                  


His Pro Pro Pro Gln Ala Ala Leu Thr Arg Ala Leu Arg Arg Leu Gln 
65                  70                  75                  80  


Pro Gly Ser Val Ala Pro Gly Asn Gly Glu Glu Val Ile Ser Phe Ala 
                85                  90                  95      


Thr Val Thr Asp Ser Thr Ser Ala Tyr Ser Ser Leu Leu Thr Phe His 
            100                 105                 110         


Leu Ser Thr Pro Arg Ser His His Leu Tyr His Ala Arg Leu Trp Leu 
        115                 120                 125             


His Val Leu Pro Thr Leu Pro Gly Thr Leu Cys Leu Arg Ile Phe Arg 
    130                 135                 140                 


Trp Gly Pro Arg Arg Arg Arg Gln Gly Ser Arg Thr Leu Leu Ala Glu 
145                 150                 155                 160 


His His Ile Thr Asn Leu Gly Trp His Thr Leu Thr Leu Pro Ser Ser 
                165                 170                 175     


Gly Leu Arg Gly Glu Lys Ser Gly Val Leu Lys Leu Gln Leu Asp Cys 
            180                 185                 190         


Arg Pro Leu Glu Gly Asn Ser Thr Val Thr Gly Gln Pro Arg Arg Leu 
        195                 200                 205             


Leu Asp Thr Ala Gly His Gln Gln Pro Phe Leu Glu Leu Lys Ile Arg 
    210                 215                 220                 


Ala Asn Glu Pro Gly Ala Gly Arg Ala Arg Arg Arg Thr Pro Thr Cys 
225                 230                 235                 240 


Glu Pro Ala Thr Pro Leu Cys Cys Arg Arg Asp His Tyr Val Asp Phe 
                245                 250                 255     


Gln Glu Leu Gly Trp Arg Asp Trp Ile Leu Gln Pro Glu Gly Tyr Gln 
            260                 265                 270         


Leu Asn Tyr Cys Ser Gly Gln Cys Pro Pro His Leu Ala Gly Ser Pro 
        275                 280                 285             


Gly Ile Ala Ala Ser Phe His Ser Ala Val Phe Ser Leu Leu Lys Ala 
    290                 295                 300                 


Asn Asn Pro Trp Pro Ala Ser Thr Ser Cys Cys Val Pro Thr Ala Arg 
305                 310                 315                 320 


Arg Pro Leu Ser Leu Leu Tyr Leu Asp His Asn Gly Asn Val Val Lys 
                325                 330                 335     


Thr Asp Val Pro Asp Met Val Val Glu Ala Cys Gly Cys Ser 
            340                 345                 350 


<210>  5508
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INO80B__Homo_sapiens__NP_112578

<400>  5508

Met Ser Lys Leu Trp Arg Arg Gly Ser Thr Ser Gly Ala Met Glu Ala 
1               5                   10                  15      


Pro Glu Pro Gly Glu Ala Leu Glu Leu Ser Leu Ala Gly Ala His Gly 
            20                  25                  30          


His Gly Val His Lys Lys Lys His Lys Lys His Lys Lys Lys His Lys 
        35                  40                  45              


Lys Lys His His Gln Glu Glu Asp Ala Gly Pro Thr Gln Pro Ser Pro 
    50                  55                  60                  


Ala Lys Pro Gln Leu Lys Leu Lys Ile Lys Leu Gly Gly Gln Val Leu 
65                  70                  75                  80  


Gly Thr Lys Ser Val Pro Thr Phe Thr Val Ile Pro Glu Gly Pro Arg 
                85                  90                  95      


Ser Pro Ser Pro Leu Met Val Val Asp Asn Glu Glu Glu Pro Met Glu 
            100                 105                 110         


Gly Val Pro Leu Glu Gln Tyr Arg Ala Trp Leu Asp Glu Asp Ser Asn 
        115                 120                 125             


Leu Ser Pro Ser Pro Leu Arg Asp Leu Ser Gly Gly Leu Gly Gly Gln 
    130                 135                 140                 


Glu Glu Glu Glu Glu Gln Arg Trp Leu Asp Ala Leu Glu Lys Gly Glu 
145                 150                 155                 160 


Leu Asp Asp Asn Gly Asp Leu Lys Lys Glu Ile Asn Glu Arg Leu Leu 
                165                 170                 175     


Thr Ala Arg Gln Arg Ala Leu Leu Gln Lys Ala Arg Ser Gln Pro Ser 
            180                 185                 190         


Pro Met Leu Pro Leu Pro Val Ala Glu Gly Cys Pro Pro Pro Ala Leu 
        195                 200                 205             


Thr Glu Glu Met Leu Leu Lys Arg Glu Glu Arg Ala Arg Lys Arg Arg 
    210                 215                 220                 


Leu Gln Ala Ala Arg Arg Ala Glu Glu His Lys Asn Gln Thr Ile Glu 
225                 230                 235                 240 


Arg Leu Thr Lys Thr Ala Ala Thr Ser Gly Arg Gly Gly Arg Gly Gly 
                245                 250                 255     


Ala Arg Gly Glu Arg Arg Gly Gly Arg Ala Ala Ala Pro Ala Pro Met 
            260                 265                 270         


Val Arg Tyr Cys Ser Gly Ala Gln Gly Ser Thr Leu Ser Phe Pro Pro 
        275                 280                 285             


Gly Val Pro Ala Pro Thr Ala Val Ser Gln Arg Pro Ser Pro Ser Gly 
    290                 295                 300                 


Pro Pro Pro Arg Cys Ser Val Pro Gly Cys Pro His Pro Arg Arg Tyr 
305                 310                 315                 320 


Ala Cys Ser Arg Thr Gly Gln Ala Leu Cys Ser Leu Gln Cys Tyr Arg 
                325                 330                 335     


Ile Asn Leu Gln Met Arg Leu Gly Gly Pro Glu Gly Pro Gly Ser Pro 
            340                 345                 350         


Leu Leu Ala Thr 
        355     


<210>  5509
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INO80D__Homo_sapiens__NP_060229

<400>  5509

Met Tyr Glu Gly Lys His Ile His Phe Ser Glu Val Asp Asn Lys Pro 
1               5                   10                  15      


Leu Cys Ser Tyr Ser Pro Lys Leu Cys Lys Gln Arg Arg Leu Asn Gly 
            20                  25                  30          


Tyr Ala Phe Cys Ile Arg His Val Leu Glu Asp Lys Thr Ala Pro Phe 
        35                  40                  45              


Lys Gln Cys Glu Tyr Val Ala Lys Tyr Asn Ser Gln Arg Cys Thr Asn 
    50                  55                  60                  


Pro Ile Pro Lys Ser Glu Asp Arg Arg Tyr Cys Asn Ser His Leu Gln 
65                  70                  75                  80  


Val Leu Gly Phe Ile Pro Lys Lys Glu Arg Lys Lys Lys Asn Asp Pro 
                85                  90                  95      


Ile Asp Glu Val Lys Val Arg His Gln Met Asp Thr Met Ala Phe Ser 
            100                 105                 110         


Leu Thr Val Pro Thr Leu Ala Leu Lys Met Pro Asn Gly Leu Asp Gly 
        115                 120                 125             


Met Ser Leu Ser Pro Pro Gly Ala Arg Val Pro Leu His Tyr Leu Glu 
    130                 135                 140                 


Thr Glu Leu Glu Asp Pro Phe Ala Phe Asn Glu Glu Asp Asp Asp Leu 
145                 150                 155                 160 


Lys Lys Gly Ala Thr Val Arg Lys Lys Leu Gln Ser Lys Leu Ala Gln 
                165                 170                 175     


Asn Arg Gln Arg Gln Arg Glu Thr Glu Ile Leu Lys Val Arg Gln Glu 
            180                 185                 190         


His Phe Ser Pro Pro Pro Ala Pro Ser Gln Gln Gln Pro Pro Gln Gln 
        195                 200                 205             


His Ser His Leu Ser Pro Leu Ser Thr Ser Leu Lys Pro Pro Ala Pro 
    210                 215                 220                 


Pro Gln Gly Ser Val Cys Lys Ser Pro Gln Pro Gln Asn Thr Ser Leu 
225                 230                 235                 240 


Pro Met Gln Gly Val Ala Pro Thr Thr His Thr Ile Ala Gln Ala Arg 
                245                 250                 255     


Gln Leu Ser His Lys Arg Pro Leu Pro Leu Leu Pro Ser Ser Arg Ala 
            260                 265                 270         


Pro Thr Val Asp Pro Pro Arg Thr Asp Arg Ile Leu Met Lys Ala Thr 
        275                 280                 285             


Ala Phe Ser Pro His Phe Ser Cys Ile Ser Arg Leu Gln Arg Leu Val 
    290                 295                 300                 


Lys Leu Cys Thr Gln Lys His Gln Leu Asp Thr Asp Leu Phe Pro His 
305                 310                 315                 320 


Leu Gly Leu Asp Trp Ser Glu Glu Ser Gly Glu Glu Pro Glu Asp Ser 
                325                 330                 335     


Glu Gln Ala Ser Pro Tyr Gln Val Ala Trp Ser Ile Arg Glu Thr Leu 
            340                 345                 350         


Arg Tyr Gln Arg His Ala Ser Asp Asp Asp Asp Ala Glu Ser Arg Ser 
        355                 360                 365             


Ser Arg Val Thr Gln Leu Cys Thr Tyr Phe Gln Gln Lys Tyr Lys His 
    370                 375                 380                 


Leu Cys Arg Leu Glu Arg Ala Glu Ser Arg Gln Lys Lys Cys Arg His 
385                 390                 395                 400 


Thr Phe Arg Lys Ala Leu Leu Gln Ala Ala Ser Lys Glu Pro Glu Cys 
                405                 410                 415     


Thr Gly Gln Leu Ile Gln Glu Leu Arg Arg Ala Ala Cys Ser Arg Thr 
            420                 425                 430         


Ser Ile Ser Arg Thr Lys Leu Arg Glu Val Glu Pro Ala Ala Cys Ser 
        435                 440                 445             


Gly Thr Val Lys Gly Glu Gln Cys Ala Asn Lys Ala Leu Pro Phe Thr 
    450                 455                 460                 


Arg His Cys Phe Gln His Ile Leu Leu Asn His Ser Gln Gln Leu Phe 
465                 470                 475                 480 


Ser Ser Cys Thr Ala Lys Phe Ala Asp Gly Gln Gln Cys Ser Val Pro 
                485                 490                 495     


Val Phe Asp Ile Thr His Gln Thr Pro Leu Cys Glu Glu His Ala Lys 
            500                 505                 510         


Lys Met Asp Asn Phe Leu Arg Gly Asp Asn Ser Arg Lys Val Gln His 
        515                 520                 525             


Gln Gln Gln Arg Lys Pro Arg Lys Lys Thr Lys Pro Pro Ala Leu Thr 
    530                 535                 540                 


Lys Lys His Lys Lys Lys Arg Arg Arg Gly Pro Arg Arg Pro Gln Lys 
545                 550                 555                 560 


Pro Ile Pro Pro Ala Val Pro Gln Gly Asn Leu Ser Met Pro Ala Ser 
                565                 570                 575     


Val Ser Leu Pro Val Glu Ala Ser His Ile Arg Ser Pro Ser Thr Pro 
            580                 585                 590         


Glu Leu Ser Ala Asp Glu Leu Pro Asp Asp Ile Ala Asn Glu Ile Thr 
        595                 600                 605             


Asp Ile Pro His Asp Leu Glu Leu Asn Gln Glu Asp Phe Ser Asp Val 
    610                 615                 620                 


Leu Pro Arg Leu Pro Asp Asp Leu Gln Asp Phe Asp Phe Phe Glu Gly 
625                 630                 635                 640 


Lys Asn Gly Asp Leu Leu Pro Thr Thr Glu Glu Ala Glu Glu Leu Glu 
                645                 650                 655     


Arg Ala Leu Gln Ala Val Thr Ser Leu Glu Cys Leu Ser Thr Ile Gly 
            660                 665                 670         


Val Leu Ala Gln Ser Asp Gly Val Pro Val Gln Glu Leu Ser Asp Arg 
        675                 680                 685             


Gly Ile Gly Val Phe Ser Thr Gly Thr Gly Ala Ser Gly Ile Gln Ser 
    690                 695                 700                 


Leu Ser Arg Glu Val Asn Thr Asp Leu Gly Glu Leu Leu Asn Gly Arg 
705                 710                 715                 720 


Ile Val His Asp Asn Phe Ser Ser Leu Glu Leu Asp Glu Asn Leu Leu 
                725                 730                 735     


Arg Ser Ala Thr Leu Ser Asn Pro Pro Thr Pro Leu Ala Gly Gln Ile 
            740                 745                 750         


Gln Gly Gln Phe Ser Ala Pro Ala Asn Val Gly Leu Thr Ser Ala Thr 
        755                 760                 765             


Leu Ile Ser Gln Ser Ala Leu Gly Glu Arg Ala Phe Pro Gly Gln Phe 
    770                 775                 780                 


His Gly Leu His Asp Gly Ser His Ala Ser Gln Arg Pro His Pro Ala 
785                 790                 795                 800 


Gln Leu Leu Ser Lys Ala Asp Asp Leu Ile Thr Ser Arg Gln Gln Tyr 
                805                 810                 815     


Ser Ser Asp His Ser His Ser Ser Pro His Gly Ser His Tyr Asp Ser 
            820                 825                 830         


Glu His Val Pro Ser Pro Tyr Ser Asp His Ile Thr Ser Pro His Thr 
        835                 840                 845             


Thr Ser Tyr Ser Gly Asp Asn Met Ala Ala Thr Phe Ser Ala Glu Met 
    850                 855                 860                 


Pro Ile Met Ala Gln His Leu Leu Pro Thr Gln Leu Glu Val Pro Leu 
865                 870                 875                 880 


Gly Gly Val Val Asn Pro Arg Thr His Trp Gly Asn Leu Pro Val Asn 
                885                 890                 895     


Leu Gly Asp Pro Ser Pro Phe Ser Asn Leu Leu Gly Ala Asp Gly His 
            900                 905                 910         


Leu Leu Ser Thr Ser Leu Ser Thr Pro Pro Thr Thr Ser Asn Ser Glu 
        915                 920                 925             


Thr Thr Gln Pro Ala Phe Ala Thr Val Thr Pro Ser Ser Ser Ser Val 
    930                 935                 940                 


Leu Pro Gly Leu Pro Gln Thr Ser Phe Ser Gly Met Gly Pro Ser Ala 
945                 950                 955                 960 


Glu Leu Met Ala Ser Thr Ser Pro Lys Gln Gln Leu Pro Gln Phe Ser 
                965                 970                 975     


Ala Ala Phe Gly His Gln Leu Ser Ser His Ser Gly Ile Pro Lys Asp 
            980                 985                 990         


Leu Gln Pro Ser His Ser Ser Ile  Ala Pro Pro Thr Gly  Phe Thr Val 
        995                 1000                 1005             


Thr Gly  Ala Thr Ala Thr Ser  Thr Asn Asn Ala Ser  Ser Pro Phe 
    1010                 1015                 1020             


Pro Ser  Pro Asn 
    1025         


<210>  5510
<211>  1556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INO80__Homo_sapiens__NP_060023

<400>  5510

Met Ala Ser Glu Leu Gly Ala Arg Asp Asp Gly Gly Cys Thr Glu Leu 
1               5                   10                  15      


Ala Lys Pro Leu Tyr Leu Gln Tyr Leu Glu Arg Ala Leu Arg Leu Asp 
            20                  25                  30          


His Phe Leu Arg Gln Thr Ser Ala Ile Phe Asn Arg Asn Ile Ser Ser 
        35                  40                  45              


Asp Asp Ser Glu Asp Gly Leu Asp Asp Ser Asn Pro Leu Leu Pro Gln 
    50                  55                  60                  


Ser Gly Asp Pro Leu Ile Gln Val Lys Glu Glu Pro Pro Asn Ser Leu 
65                  70                  75                  80  


Leu Gly Glu Thr Ser Gly Ala Gly Ser Ser Gly Met Leu Asn Thr Tyr 
                85                  90                  95      


Ser Leu Asn Gly Val Leu Gln Ser Glu Ser Lys Cys Asp Lys Gly Asn 
            100                 105                 110         


Leu Tyr Asn Phe Ser Lys Leu Lys Lys Ser Arg Lys Trp Leu Lys Ser 
        115                 120                 125             


Ile Leu Leu Ser Asp Glu Ser Ser Glu Ala Asp Ser Gln Ser Glu Asp 
    130                 135                 140                 


Asp Asp Glu Glu Glu Leu Asn Leu Ser Arg Glu Glu Leu His Asn Met 
145                 150                 155                 160 


Leu Arg Leu His Lys Tyr Lys Lys Leu His Gln Asn Lys Tyr Ser Lys 
                165                 170                 175     


Asp Lys Glu Leu Gln Gln Tyr Gln Tyr Tyr Ser Ala Gly Leu Leu Ser 
            180                 185                 190         


Thr Tyr Asp Pro Phe Tyr Glu Gln Gln Arg His Leu Leu Gly Pro Lys 
        195                 200                 205             


Lys Lys Lys Phe Lys Glu Glu Lys Lys Leu Lys Ala Lys Leu Lys Lys 
    210                 215                 220                 


Val Lys Lys Lys Arg Arg Arg Asp Glu Glu Leu Ser Ser Glu Glu Ser 
225                 230                 235                 240 


Pro Arg Arg His His His Gln Thr Lys Val Phe Ala Lys Phe Ser His 
                245                 250                 255     


Asp Ala Pro Pro Pro Gly Thr Lys Lys Lys His Leu Ser Ile Glu Gln 
            260                 265                 270         


Leu Asn Ala Arg Arg Arg Lys Val Trp Leu Ser Ile Val Lys Lys Glu 
        275                 280                 285             


Leu Pro Lys Ala Asn Lys Gln Lys Ala Ser Ala Arg Asn Leu Phe Leu 
    290                 295                 300                 


Thr Asn Ser Arg Lys Leu Ala His Gln Cys Met Lys Glu Val Arg Arg 
305                 310                 315                 320 


Ala Ala Leu Gln Ala Gln Lys Asn Cys Lys Glu Thr Leu Pro Arg Ala 
                325                 330                 335     


Arg Arg Leu Thr Lys Glu Met Leu Leu Tyr Trp Lys Lys Tyr Glu Lys 
            340                 345                 350         


Val Glu Lys Glu His Arg Lys Arg Ala Glu Lys Glu Ala Leu Glu Gln 
        355                 360                 365             


Arg Lys Leu Asp Glu Glu Met Arg Glu Ala Lys Arg Gln Gln Arg Lys 
    370                 375                 380                 


Leu Asn Phe Leu Ile Thr Gln Thr Glu Leu Tyr Ala His Phe Met Ser 
385                 390                 395                 400 


Arg Lys Arg Asp Met Gly His Asp Gly Ile Gln Glu Glu Ile Leu Arg 
                405                 410                 415     


Lys Leu Glu Asp Ser Ser Thr Gln Arg Gln Ile Asp Ile Gly Gly Gly 
            420                 425                 430         


Val Val Val Asn Ile Thr Gln Glu Asp Tyr Asp Ser Asn His Phe Lys 
        435                 440                 445             


Ala Gln Ala Leu Lys Asn Ala Glu Asn Ala Tyr His Ile His Gln Ala 
    450                 455                 460                 


Arg Thr Arg Ser Phe Asp Glu Asp Ala Lys Glu Ser Arg Ala Ala Ala 
465                 470                 475                 480 


Leu Arg Ala Ala Asn Lys Ser Gly Thr Gly Phe Gly Glu Ser Tyr Ser 
                485                 490                 495     


Leu Ala Asn Pro Ser Ile Arg Ala Gly Glu Asp Ile Pro Gln Pro Thr 
            500                 505                 510         


Ile Phe Asn Gly Lys Leu Lys Gly Tyr Gln Leu Lys Gly Met Asn Trp 
        515                 520                 525             


Leu Ala Asn Leu Tyr Glu Gln Gly Ile Asn Gly Ile Leu Ala Asp Glu 
    530                 535                 540                 


Met Gly Leu Gly Lys Thr Val Gln Ser Ile Ala Leu Leu Ala His Leu 
545                 550                 555                 560 


Ala Glu Arg Glu Asn Ile Trp Gly Pro Phe Leu Ile Ile Ser Pro Ala 
                565                 570                 575     


Ser Thr Leu Asn Asn Trp His Gln Glu Phe Thr Arg Phe Val Pro Lys 
            580                 585                 590         


Phe Lys Val Leu Pro Tyr Trp Gly Asn Pro His Asp Arg Lys Val Ile 
        595                 600                 605             


Arg Arg Phe Trp Ser Gln Lys Thr Leu Tyr Thr Gln Asp Ala Pro Phe 
    610                 615                 620                 


His Val Val Ile Thr Ser Tyr Gln Leu Val Val Gln Asp Val Lys Tyr 
625                 630                 635                 640 


Phe Gln Arg Val Lys Trp Gln Tyr Met Val Leu Asp Glu Ala Gln Ala 
                645                 650                 655     


Leu Lys Ser Ser Ser Ser Val Arg Trp Lys Ile Leu Leu Gln Phe Gln 
            660                 665                 670         


Cys Arg Asn Arg Leu Leu Leu Thr Gly Thr Pro Ile Gln Asn Thr Met 
        675                 680                 685             


Ala Glu Leu Trp Ala Leu Leu His Phe Ile Met Pro Thr Leu Phe Asp 
    690                 695                 700                 


Ser His Glu Glu Phe Asn Glu Trp Phe Ser Lys Asp Ile Glu Ser His 
705                 710                 715                 720 


Ala Glu Asn Lys Ser Ala Ile Asp Glu Asn Gln Leu Ser Arg Leu His 
                725                 730                 735     


Met Ile Leu Lys Pro Phe Met Leu Arg Arg Ile Lys Lys Asp Val Glu 
            740                 745                 750         


Asn Glu Leu Ser Asp Lys Ile Glu Ile Leu Met Tyr Cys Gln Leu Thr 
        755                 760                 765             


Ser Arg Gln Lys Leu Leu Tyr Gln Ala Leu Lys Asn Lys Ile Ser Ile 
    770                 775                 780                 


Glu Asp Leu Leu Gln Ser Ser Met Gly Ser Thr Gln Gln Ala Gln Asn 
785                 790                 795                 800 


Thr Thr Ser Ser Leu Met Asn Leu Val Met Gln Phe Arg Lys Val Cys 
                805                 810                 815     


Asn His Pro Glu Leu Phe Glu Arg Gln Glu Thr Trp Ser Pro Phe His 
            820                 825                 830         


Ile Ser Leu Lys Pro Tyr His Ile Ser Lys Phe Ile Tyr Arg His Gly 
        835                 840                 845             


Gln Ile Arg Val Phe Asn His Ser Arg Asp Arg Trp Leu Arg Val Leu 
    850                 855                 860                 


Ser Pro Phe Ala Pro Asp Tyr Ile Gln Arg Ser Leu Phe His Arg Lys 
865                 870                 875                 880 


Gly Ile Asn Glu Glu Ser Cys Phe Ser Phe Leu Arg Phe Ile Asp Ile 
                885                 890                 895     


Ser Pro Ala Glu Met Ala Asn Leu Met Leu Gln Gly Leu Leu Ala Arg 
            900                 905                 910         


Trp Leu Ala Leu Phe Leu Ser Leu Lys Ala Ser Tyr Arg Leu His Gln 
        915                 920                 925             


Leu Arg Ser Trp Gly Ala Pro Glu Gly Glu Ser His Gln Arg Tyr Leu 
    930                 935                 940                 


Arg Asn Lys Asp Phe Leu Leu Gly Val Asn Phe Pro Leu Ser Phe Pro 
945                 950                 955                 960 


Asn Leu Cys Ser Cys Pro Leu Leu Lys Ser Leu Val Phe Ser Ser His 
                965                 970                 975     


Cys Lys Ala Val Ser Gly Tyr Ser Asp Gln Val Val His Gln Arg Arg 
            980                 985                 990         


Ser Ala Thr Ser Ser Leu Arg Arg  Cys Leu Leu Thr Glu  Leu Pro Ser 
        995                 1000                 1005             


Phe Leu  Cys Val Ala Ser Pro  Arg Val Thr Ala Val  Pro Leu Asp 
    1010                 1015                 1020             


Ser Tyr  Cys Asn Asp Arg Ser  Ala Glu Tyr Glu Arg  Arg Val Leu 
    1025                 1030                 1035             


Lys Glu  Gly Gly Ser Leu Ala  Ala Lys Gln Cys Leu  Leu Asn Gly 
    1040                 1045                 1050             


Ala Pro  Glu Leu Ala Ala Asp  Trp Leu Asn Arg Arg  Ser Gln Phe 
    1055                 1060                 1065             


Phe Pro  Glu Pro Ala Gly Gly  Leu Trp Ser Ile Arg  Pro Gln Asn 
    1070                 1075                 1080             


Gly Trp  Ser Phe Ile Arg Ile  Pro Gly Lys Glu Ser  Leu Ile Thr 
    1085                 1090                 1095             


Asp Ser  Gly Lys Leu Tyr Ala  Leu Asp Val Leu Leu  Thr Arg Leu 
    1100                 1105                 1110             


Lys Ser  Gln Gly His Arg Val  Leu Ile Tyr Ser Gln  Met Thr Arg 
    1115                 1120                 1125             


Met Ile  Asp Leu Leu Glu Glu  Tyr Met Val Tyr Arg  Lys His Thr 
    1130                 1135                 1140             


Tyr Met  Arg Leu Asp Gly Ser  Ser Lys Ile Ser Glu  Arg Arg Asp 
    1145                 1150                 1155             


Met Val  Ala Asp Phe Gln Asn  Arg Asn Asp Ile Phe  Val Phe Leu 
    1160                 1165                 1170             


Leu Ser  Thr Arg Ala Gly Gly  Leu Gly Ile Asn Leu  Thr Ala Ala 
    1175                 1180                 1185             


Asp Thr  Val Ile Phe Tyr Asp  Ser Asp Trp Asn Pro  Thr Val Asp 
    1190                 1195                 1200             


Gln Gln  Ala Met Asp Arg Ala  His Arg Leu Gly Gln  Thr Lys Gln 
    1205                 1210                 1215             


Val Thr  Val Tyr Arg Leu Ile  Cys Lys Gly Thr Ile  Glu Glu Arg 
    1220                 1225                 1230             


Ile Leu  Gln Arg Ala Lys Glu  Lys Ser Glu Ile Gln  Arg Met Val 
    1235                 1240                 1245             


Ile Ser  Gly Gly Asn Phe Lys  Pro Asp Thr Leu Lys  Pro Lys Glu 
    1250                 1255                 1260             


Val Val  Ser Leu Leu Leu Asp  Asp Glu Glu Leu Glu  Lys Lys Leu 
    1265                 1270                 1275             


Arg Leu  Arg Gln Glu Glu Lys  Arg Gln Gln Glu Glu  Thr Asn Arg 
    1280                 1285                 1290             


Val Lys  Glu Arg Lys Arg Lys  Arg Glu Lys Tyr Ala  Glu Lys Lys 
    1295                 1300                 1305             


Lys Lys  Glu Asp Glu Leu Asp  Gly Lys Arg Arg Lys  Glu Gly Val 
    1310                 1315                 1320             


Asn Leu  Val Ile Pro Phe Val  Pro Ser Ala Asp Asn  Ser Asn Leu 
    1325                 1330                 1335             


Ser Ala  Asp Gly Asp Asp Ser  Phe Ile Ser Val Asp  Ser Ala Met 
    1340                 1345                 1350             


Pro Ser  Pro Phe Ser Glu Ile  Ser Ile Ser Ser Glu  Leu His Thr 
    1355                 1360                 1365             


Gly Ser  Ile Pro Leu Asp Glu  Ser Ser Ser Asp Met  Leu Val Ile 
    1370                 1375                 1380             


Val Asp  Asp Pro Ala Ser Ser  Ala Pro Gln Ser Arg  Ala Thr Asn 
    1385                 1390                 1395             


Ser Pro  Ala Ser Ile Thr Gly  Ser Val Ser Asp Thr  Val Asn Gly 
    1400                 1405                 1410             


Ile Ser  Ile Gln Glu Met Pro  Ala Ala Gly Arg Gly  His Ser Ala 
    1415                 1420                 1425             


Arg Ser  Arg Gly Arg Pro Lys  Gly Ser Gly Ser Thr  Ala Lys Gly 
    1430                 1435                 1440             


Ala Gly  Lys Gly Arg Ser Arg  Lys Ser Thr Ala Gly  Ser Ala Ala 
    1445                 1450                 1455             


Ala Met  Ala Gly Ala Lys Ala  Gly Ala Ala Ala Ala  Ser Ala Ala 
    1460                 1465                 1470             


Ala Tyr  Ala Ala Tyr Gly Tyr  Asn Val Ser Lys Gly  Ile Ser Ala 
    1475                 1480                 1485             


Ser Ser  Pro Leu Gln Thr Ser  Leu Val Arg Pro Ala  Gly Leu Ala 
    1490                 1495                 1500             


Asp Phe  Gly Pro Ser Ser Ala  Ser Ser Pro Leu Ser  Ser Pro Leu 
    1505                 1510                 1515             


Ser Lys  Gly Asn Asn Val Pro  Gly Asn Pro Lys Asn  Leu His Met 
    1520                 1525                 1530             


Thr Ser  Ser Leu Ala Pro Asp  Ser Leu Val Arg Lys  Gln Gly Lys 
    1535                 1540                 1545             


Gly Thr  Asn Pro Ser Gly Gly  Arg 
    1550                 1555     


<210>  5511
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP1__Homo_sapiens__NP_001122400

<400>  5511

Met Ser Asp Ile Leu Arg Glu Leu Leu Cys Val Ser Glu Lys Ala Ala 
1               5                   10                  15      


Asn Ile Ala Arg Ala Cys Arg Gln Gln Glu Ala Leu Phe Gln Leu Leu 
            20                  25                  30          


Ile Glu Glu Lys Lys Glu Gly Glu Lys Asn Lys Lys Phe Ala Val Asp 
        35                  40                  45              


Phe Lys Thr Leu Ala Asp Val Leu Val Gln Glu Val Ile Lys Gln Asn 
    50                  55                  60                  


Met Glu Asn Lys Phe Pro Gly Leu Glu Lys Asn Ile Phe Gly Glu Glu 
65                  70                  75                  80  


Ser Asn Glu Phe Thr Asn Asp Trp Gly Glu Lys Ile Thr Leu Arg Leu 
                85                  90                  95      


Cys Ser Thr Glu Glu Glu Thr Ala Glu Leu Leu Ser Lys Val Leu Asn 
            100                 105                 110         


Gly Asn Lys Val Ala Ser Glu Ala Leu Ala Arg Val Val His Gln Asp 
        115                 120                 125             


Val Ala Phe Thr Asp Pro Thr Leu Asp Ser Thr Glu Ile Asn Val Pro 
    130                 135                 140                 


Gln Asp Ile Leu Gly Ile Trp Val Asp Pro Ile Asp Ser Thr Tyr Gln 
145                 150                 155                 160 


Tyr Ile Lys Gly Ser Ala Asp Ile Lys Ser Asn Gln Gly Ile Phe Pro 
                165                 170                 175     


Cys Gly Leu Gln Cys Val Thr Ile Leu Ile Gly Val Tyr Asp Ile Gln 
            180                 185                 190         


Thr Gly Val Pro Leu Met Gly Val Ile Asn Gln Pro Phe Val Ser Arg 
        195                 200                 205             


Asp Pro Asn Thr Leu Arg Trp Lys Gly Gln Cys Tyr Trp Gly Leu Ser 
    210                 215                 220                 


Tyr Met Gly Thr Asn Met His Ser Leu Gln Leu Thr Ile Ser Arg Arg 
225                 230                 235                 240 


Asn Gly Ser Glu Thr His Thr Gly Asn Thr Gly Ser Glu Ala Ala Phe 
                245                 250                 255     


Ser Pro Ser Phe Ser Ala Val Ile Ser Thr Ser Glu Lys Glu Thr Ile 
            260                 265                 270         


Lys Ala Ala Leu Ser Arg Val Cys Gly Asp Arg Ile Phe Gly Ala Ala 
        275                 280                 285             


Gly Ala Gly Tyr Lys Ser Leu Cys Val Val Gln Gly Leu Val Asp Ile 
    290                 295                 300                 


Tyr Ile Phe Ser Glu Asp Thr Thr Phe Lys Trp Asp Ser Cys Ala Ala 
305                 310                 315                 320 


His Ala Ile Leu Arg Ala Met Gly Gly Gly Ile Val Asp Leu Lys Glu 
                325                 330                 335     


Cys Leu Glu Arg Asn Pro Glu Thr Gly Leu Asp Leu Pro Gln Leu Val 
            340                 345                 350         


Tyr His Val Glu Asn Glu Gly Ala Ala Gly Val Asp Arg Trp Ala Asn 
        355                 360                 365             


Lys Gly Gly Leu Ile Ala Tyr Arg Ser Arg Lys Arg Leu Glu Thr Phe 
    370                 375                 380                 


Leu Ser Leu Leu Val Gln Asn Leu Ala Pro Ala Glu Thr His Thr 
385                 390                 395                 


<210>  5512
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP4A__Homo_sapiens__NP_001127696

<400>  5512

Met Thr Ala Arg Glu His Ser Pro Arg His Gly Ala Arg Ala Arg Ala 
1               5                   10                  15      


Met Gln Arg Ala Ser Thr Ile Asp Val Ala Ala Asp Met Leu Gly Leu 
            20                  25                  30          


Ser Leu Ala Gly Asn Ile Gln Asp Pro Asp Glu Pro Ile Leu Glu Phe 
        35                  40                  45              


Ser Leu Ala Cys Ser Glu Leu His Thr Pro Ser Leu Asp Arg Lys Pro 
    50                  55                  60                  


Asn Ser Phe Val Ala Val Ser Val Thr Thr Pro Pro Gln Ala Phe Trp 
65                  70                  75                  80  


Thr Lys His Ala Gln Thr Glu Ile Ile Glu Gly Thr Asn Asn Pro Ile 
                85                  90                  95      


Phe Leu Ser Ser Ile Ala Phe Phe Gln Asp Ser Leu Ile Asn Gln Met 
            100                 105                 110         


Thr Gln Val Lys Leu Ser Val Tyr Asp Val Lys Asp Arg Ser Gln Gly 
        115                 120                 125             


Thr Met Tyr Leu Leu Gly Ser Gly Thr Phe Ile Val Lys Asp Leu Leu 
    130                 135                 140                 


Gln Asp Arg His His Arg Leu His Leu Thr Leu Arg Ser Ala Glu Ser 
145                 150                 155                 160 


Asp Arg Val Gly Asn Ile Thr Val Ile Gly Trp Gln Met Glu Glu Lys 
                165                 170                 175     


Ser Asp Gln Arg Pro Pro Val Thr Arg Ser Val Asp Thr Val Asn Gly 
            180                 185                 190         


Arg Met Val Leu Pro Val Asp Glu Ser Leu Thr Glu Ala Leu Gly Ile 
        195                 200                 205             


Arg Ser Lys Tyr Ala Ser Leu Arg Lys Asp Thr Leu Leu Lys Ser Val 
    210                 215                 220                 


Phe Gly Gly Ala Ile Cys Arg Met Tyr Arg Phe Pro Thr Thr Asp Gly 
225                 230                 235                 240 


Asn His Leu Arg Ile Leu Glu Gln Met Ala Glu Ser Val Leu Ser Leu 
                245                 250                 255     


His Val Pro Arg Gln Phe Val Lys Leu Leu Leu Glu Glu Asp Ala Ala 
            260                 265                 270         


Arg Val Cys Glu Leu Glu Glu Leu Gly Glu Leu Ser Pro Cys Trp Glu 
        275                 280                 285             


Ser Leu Arg Arg Gln Ile Val Thr Gln Tyr Gln Thr Ile Ile Leu Thr 
    290                 295                 300                 


Tyr Gln Glu Asn Leu Thr Asp Leu His Gln Tyr Arg Gly Pro Ser Phe 
305                 310                 315                 320 


Lys Ala Ser Ser Leu Lys Ala Asp Lys Lys Leu Glu Phe Val Pro Thr 
                325                 330                 335     


Asn Leu His Ile Gln Arg Met Arg Val Gln Asp Asp Gly Gly Ser Asp 
            340                 345                 350         


Gln Asn Tyr Asp Ile Val Thr Ile Gly Ala Pro Ala Ala His Cys Gln 
        355                 360                 365             


Gly Phe Lys Ser Gly Gly Leu Arg Lys Lys Leu His Lys Phe Glu Glu 
    370                 375                 380                 


Thr Lys Lys His Phe Glu Glu Cys Cys Thr Ser Ser Gly Cys Gln Ser 
385                 390                 395                 400 


Ile Ile Tyr Ile Pro Gln Asp Val Val Arg Ala Lys Glu Ile Ile Ala 
                405                 410                 415     


Gln Ile Asn Thr Leu Lys Thr Gln Val Ser Tyr Tyr Ala Glu Arg Leu 
            420                 425                 430         


Ser Arg Ala Ala Lys Asp Arg Ser Ala Thr Gly Leu Glu Arg Thr Leu 
        435                 440                 445             


Ala Ile Leu Ala Asp Lys Thr Arg Gln Leu Val Thr Val Cys Asp Cys 
    450                 455                 460                 


Lys Leu Leu Ala Asn Ser Ile His Gly Leu Asn Ala Ala Arg Pro Asp 
465                 470                 475                 480 


Tyr Ile Ala Ser Lys Ala Ser Pro Thr Ser Thr Glu Glu Glu Gln Val 
                485                 490                 495     


Met Leu Arg Asn Asp Gln Asp Thr Leu Met Ala Arg Trp Thr Gly Arg 
            500                 505                 510         


Asn Ser Arg Ser Ser Leu Gln Val Asp Trp His Glu Glu Glu Trp Glu 
        515                 520                 525             


Lys Val Trp Leu Asn Val Asp Lys Ser Leu Glu Cys Ile Ile Gln Arg 
    530                 535                 540                 


Val Asp Lys Leu Leu Gln Lys Glu Arg Leu His Gly Glu Gly Cys Glu 
545                 550                 555                 560 


Asp Val Phe Pro Cys Ala Gly Ser Cys Thr Ser Lys Lys Gly Asn Pro 
                565                 570                 575     


Asp Ser His Ala Tyr Trp Ile Arg Pro Glu Asp Pro Phe Cys Asp Val 
            580                 585                 590         


Pro Ser Ser Pro Cys Pro Ser Thr Met Pro Ser Thr Ala Cys His Pro 
        595                 600                 605             


His Leu Thr Thr His Cys Ser Pro Pro Pro Glu Glu Ser Ser Pro Gly 
    610                 615                 620                 


Glu Trp Ser Glu Ala Leu Tyr Pro Leu Leu Thr Thr Leu Thr Asp Cys 
625                 630                 635                 640 


Val Ala Met Met Ser Asp Lys Ala Lys Lys Ala Met Val Phe Leu Leu 
                645                 650                 655     


Met Gln Asp Ser Ala Pro Thr Ile Ala Thr Tyr Leu Ser Leu Gln Tyr 
            660                 665                 670         


Arg Arg Asp Val Val Phe Cys Gln Thr Leu Thr Ala Leu Ile Cys Gly 
        675                 680                 685             


Phe Ile Ile Lys Leu Arg Asn Cys Leu His Asp Asp Gly Phe Leu Arg 
    690                 695                 700                 


Gln Leu Tyr Thr Ile Gly Leu Leu Ala Gln Phe Glu Ser Leu Leu Ser 
705                 710                 715                 720 


Thr Tyr Gly Glu Glu Leu Ala Met Leu Glu Asp Met Ser Leu Gly Ile 
                725                 730                 735     


Met Asp Leu Arg Asn Val Thr Phe Lys Val Thr Gln Ala Thr Ser Ser 
            740                 745                 750         


Ala Ser Ala Asp Met Leu Pro Val Ile Thr Gly Asn Arg Asp Gly Phe 
        755                 760                 765             


Asn Val Arg Val Pro Leu Pro Gly Pro Leu Phe Asp Ala Leu Pro Arg 
    770                 775                 780                 


Glu Ile Gln Ser Gly Met Leu Leu Arg Val Gln Pro Val Leu Phe Asn 
785                 790                 795                 800 


Val Gly Ile Asn Glu Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Thr 
                805                 810                 815     


Ser Leu Gln Glu Val Ile Asn Val Glu Ser Leu Val Arg Leu Asn Ser 
            820                 825                 830         


Tyr Phe Glu Gln Phe Lys Glu Val Leu Pro Glu Asp Cys Leu Pro Arg 
        835                 840                 845             


Ser Arg Ser Gln Thr Cys Leu Pro Glu Leu Leu Arg Phe Leu Gly Gln 
    850                 855                 860                 


Asn Val His Ala Arg Lys Asn Lys Asn Val Asp Ile Leu Trp Gln Ala 
865                 870                 875                 880 


Ala Glu Ile Cys Arg Arg Leu Asn Gly Val Arg Phe Thr Ser Cys Lys 
                885                 890                 895     


Ser Ala Lys Asp Arg Thr Ala Met Ser Val Thr Leu Glu Gln Cys Leu 
            900                 905                 910         


Ile Leu Gln His Glu His Gly Met Ala Pro Gln Val Phe Thr Gln Ala 
        915                 920                 925             


Leu Glu Cys Met Arg Ser Glu Gly Cys Arg Arg Glu Asn Thr Met Lys 
    930                 935                 940                 


Asn Val Gly Ser Arg Lys Tyr Ala Phe Asn Ser Leu Gln Leu Lys Ala 
945                 950                 955                 960 


Phe Pro Lys His Tyr Arg Pro Pro Glu Gly Thr Tyr Gly Lys Val Glu 
                965                 970                 975     


Thr 
    


<210>  5513
<211>  924
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP4B__Homo_sapiens__NP_001095139

<400>  5513

Met Glu Ile Lys Glu Glu Gly Ala Ser Glu Glu Gly Gln His Phe Leu 
1               5                   10                  15      


Pro Thr Ala Gln Ala Asn Asp Pro Gly Asp Cys Gln Phe Thr Ser Ile 
            20                  25                  30          


Gln Lys Thr Pro Asn Glu Pro Gln Leu Glu Phe Ile Leu Ala Cys Lys 
        35                  40                  45              


Asp Leu Val Ala Pro Val Arg Asp Arg Lys Leu Asn Thr Leu Val Gln 
    50                  55                  60                  


Ile Ser Val Ile His Pro Val Glu Gln Ser Leu Thr Arg Tyr Ser Ser 
65                  70                  75                  80  


Thr Glu Ile Val Glu Gly Thr Arg Asp Pro Leu Phe Leu Thr Gly Val 
                85                  90                  95      


Thr Phe Pro Ser Glu Tyr Pro Ile Tyr Glu Glu Thr Lys Ile Lys Leu 
            100                 105                 110         


Thr Val Tyr Asp Val Lys Asp Lys Ser His Asp Thr Val Arg Thr Ser 
        115                 120                 125             


Val Leu Pro Glu His Lys Asp Pro Pro Pro Glu Val Gly Arg Ser Phe 
    130                 135                 140                 


Leu Gly Tyr Ala Ser Phe Lys Val Gly Glu Leu Leu Lys Ser Lys Glu 
145                 150                 155                 160 


Gln Leu Leu Val Leu Ser Leu Arg Thr Ser Asp Gly Gly Lys Val Val 
                165                 170                 175     


Gly Thr Ile Glu Val Ser Val Val Lys Met Gly Glu Ile Glu Asp Gly 
            180                 185                 190         


Glu Ala Asp His Ile Thr Thr Asp Val Gln Gly Gln Lys Cys Ala Leu 
        195                 200                 205             


Val Cys Glu Cys Thr Ala Pro Glu Ser Val Ser Gly Lys Asp Asn Leu 
    210                 215                 220                 


Pro Phe Leu Asn Ser Val Leu Lys Asn Pro Val Cys Lys Leu Tyr Arg 
225                 230                 235                 240 


Phe Pro Thr Ser Asp Asn Lys Trp Met Arg Ile Arg Glu Gln Met Ser 
                245                 250                 255     


Glu Ser Ile Leu Ser Phe His Ile Pro Lys Glu Leu Ile Ser Leu His 
            260                 265                 270         


Ile Lys Glu Asp Leu Cys Arg Asn Gln Glu Ile Lys Glu Leu Gly Glu 
        275                 280                 285             


Leu Ser Pro His Trp Asp Asn Leu Arg Lys Asn Val Leu Thr His Cys 
    290                 295                 300                 


Asp Gln Met Val Asn Met Tyr Gln Asp Ile Leu Thr Glu Leu Ser Lys 
305                 310                 315                 320 


Glu Thr Gly Ser Ser Phe Lys Ser Ser Ser Ser Lys Gly Glu Lys Thr 
                325                 330                 335     


Leu Glu Phe Val Pro Ile Asn Leu His Leu Gln Arg Met Gln Val His 
            340                 345                 350         


Ser Pro His Leu Lys Asp Ala Leu Tyr Asp Val Ile Thr Val Gly Ala 
        355                 360                 365             


Pro Ala Ala His Phe Gln Gly Phe Lys Asn Gly Gly Leu Arg Lys Leu 
    370                 375                 380                 


Leu His Arg Phe Glu Thr Glu Arg Arg Asn Thr Gly Tyr Gln Phe Ile 
385                 390                 395                 400 


Tyr Tyr Ser Pro Glu Asn Thr Ala Lys Ala Lys Glu Val Leu Ser Asn 
                405                 410                 415     


Ile Asn Gln Leu Gln Pro Leu Ile Ala Thr His Ala Asp Leu Leu Leu 
            420                 425                 430         


Asn Ser Ala Ser Gln His Ser Pro Asp Ser Leu Lys Asn Ser Leu Lys 
        435                 440                 445             


Met Leu Ser Glu Lys Thr Glu Leu Phe Val His Ala Phe Lys Asp Gln 
    450                 455                 460                 


Leu Val Arg Ser Ala Leu Leu Ala Leu Tyr Thr Ala Arg Pro Gly Gly 
465                 470                 475                 480 


Ile Leu Lys Lys Pro Pro Ser Pro Lys Ser Ser Thr Glu Glu Ser Ser 
                485                 490                 495     


Pro Gln Asp Gln Pro Pro Val Met Arg Gly Gln Asp Ser Ile Pro His 
            500                 505                 510         


His Ser Asp Tyr Asp Glu Glu Glu Trp Asp Arg Val Trp Ala Asn Val 
        515                 520                 525             


Gly Lys Ser Leu Asn Cys Ile Ile Ala Met Val Asp Lys Leu Ile Glu 
    530                 535                 540                 


Arg Asp Gly Gly Ser Glu Gly Ser Gly Gly Asn Asn Asp Gly Glu Lys 
545                 550                 555                 560 


Glu Pro Ser Leu Thr Asp Ala Ile Pro Ser His Pro Arg Glu Asp Trp 
                565                 570                 575     


Tyr Glu Gln Leu Tyr Pro Leu Ile Leu Thr Leu Lys Asp Cys Met Gly 
            580                 585                 590         


Glu Val Val Asn Arg Ala Lys Gln Ser Leu Thr Phe Val Leu Leu Gln 
        595                 600                 605             


Glu Leu Ala Tyr Ser Leu Pro Gln Cys Leu Met Leu Thr Leu Arg Arg 
    610                 615                 620                 


Asp Ile Val Phe Ser Gln Ala Leu Ala Gly Leu Val Cys Gly Phe Ile 
625                 630                 635                 640 


Ile Lys Leu Gln Thr Ser Leu Tyr Asp Pro Gly Phe Leu Gln Gln Leu 
                645                 650                 655     


His Thr Val Gly Leu Ile Val Gln Tyr Glu Gly Leu Leu Ser Thr Tyr 
            660                 665                 670         


Ser Asp Glu Ile Gly Met Leu Glu Asp Met Ala Val Gly Ile Ser Asp 
        675                 680                 685             


Leu Lys Lys Val Ala Phe Lys Ile Ile Glu Ala Lys Ser Asn Asp Val 
    690                 695                 700                 


Leu Pro Val Ile Thr Gly Arg Arg Glu His Tyr Val Val Glu Val Lys 
705                 710                 715                 720 


Leu Pro Ala Arg Met Phe Glu Ser Leu Pro Leu Gln Ile Lys Glu Gly 
                725                 730                 735     


Gln Leu Leu His Val Tyr Pro Val Leu Phe Asn Val Gly Ile Asn Glu 
            740                 745                 750         


Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Val Ser Leu Gln Glu Ser 
        755                 760                 765             


Ile Asn Gln Glu Asn Phe Glu Leu Leu Gln Glu Tyr Tyr Lys Ile Phe 
    770                 775                 780                 


Met Glu Lys Met Pro Pro Asp Tyr Ile Ser His Phe Gln Glu Gln Asn 
785                 790                 795                 800 


Asp Leu Lys Ala Leu Leu Glu Asn Leu Leu Gln Asn Ile Gln Ser Lys 
                805                 810                 815     


Lys Arg Lys Asn Val Glu Ile Met Trp Leu Ala Ala Thr Ile Cys Arg 
            820                 825                 830         


Lys Leu Asn Gly Ile Arg Phe Thr Cys Cys Lys Ser Ala Lys Asp Arg 
        835                 840                 845             


Thr Ser Met Ser Val Thr Leu Glu Gln Cys Ser Ile Leu Arg Asp Glu 
    850                 855                 860                 


His Gln Leu His Lys Asp Phe Phe Ile Arg Ala Leu Asp Cys Met Arg 
865                 870                 875                 880 


Arg Glu Gly Cys Arg Ile Glu Asn Val Leu Lys Asn Ile Lys Cys Arg 
                885                 890                 895     


Lys Tyr Ala Phe Asn Met Leu Gln Leu Met Ala Phe Pro Lys Tyr Tyr 
            900                 905                 910         


Arg Pro Pro Glu Gly Thr Tyr Gly Lys Ala Asp Thr 
        915                 920                 


<210>  5514
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP5A__Homo_sapiens__NP_005530

<400>  5514

Met Ala Gly Lys Ala Ala Ala Pro Gly Thr Ala Val Leu Leu Val Thr 
1               5                   10                  15      


Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln Lys Asn 
            20                  25                  30          


Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His Lys Pro His Phe 
        35                  40                  45              


Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser 
    50                  55                  60                  


Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu Ser Ser Asp Ala 
65                  70                  75                  80  


Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys 
                85                  90                  95      


Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr Phe Leu His Glu 
            100                 105                 110         


Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys Lys Tyr Arg 
        115                 120                 125             


Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu Ser Thr Pro 
    130                 135                 140                 


Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro Glu Cys Lys 
145                 150                 155                 160 


Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile Ala Asp Cys 
                165                 170                 175     


Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala Ser Asn Leu 
            180                 185                 190         


Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile Arg His Lys 
        195                 200                 205             


Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln Arg Phe Glu Lys 
    210                 215                 220                 


Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg Leu Asp Ser Lys 
225                 230                 235                 240 


Ser Val Val Glu Thr Leu Cys Thr Lys Ala Thr Met Gln Thr Val Arg 
                245                 250                 255     


Ala Ala Asp Thr Asn Glu Val Val Lys Leu Ile Phe Arg Glu Ser Asp 
            260                 265                 270         


Asn Asp Arg Lys Val Met Leu Gln Leu Glu Lys Lys Leu Phe Asp Tyr 
        275                 280                 285             


Phe Asn Gln Glu Val Phe Arg Asp Asn Asn Gly Thr Ala Leu Leu Glu 
    290                 295                 300                 


Phe Asp Lys Glu Leu Ser Val Phe Lys Asp Arg Leu Tyr Glu Leu Asp 
305                 310                 315                 320 


Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg Gln Gly 
                325                 330                 335     


Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg Ile Leu 
            340                 345                 350         


Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Ser Glu Ser Glu Glu 
        355                 360                 365             


Lys Val Val Thr Tyr Asp His Ile Gly Pro Asn Val Cys Met Gly Asp 
    370                 375                 380                 


His Lys Pro Val Phe Leu Ala Phe Arg Ile Met Pro Gly Ala Gly Lys 
385                 390                 395                 400 


Pro His Ala His Val His Lys Cys Cys Val Val Gln 
                405                 410         


<210>  5515
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP5B__Homo_sapiens__NP_001284363

<400>  5515

Met Ser Ala Ala Ala Gly Ser Arg Glu Arg Asn Thr Ala Gly Gly Ser 
1               5                   10                  15      


Asn Phe Asp Gly Leu Arg Pro Asn Gly Lys Gly Val Pro Met Asp Gln 
            20                  25                  30          


Ser Ser Arg Gly Gln Asp Lys Pro Glu Ser Leu Gln Pro Arg Gln Asn 
        35                  40                  45              


Lys Ser Lys Ser Glu Ile Thr Asp Met Val Arg Ser Ser Thr Ile Thr 
    50                  55                  60                  


Val Ser Asp Lys Ala His Ile Leu Ser Met Gln Lys Phe Gly Leu Arg 
65                  70                  75                  80  


Asp Thr Ile Val Lys Ser His Leu Leu Gln Lys Glu Glu Asp Tyr Thr 
                85                  90                  95      


Tyr Ile Gln Asn Phe Arg Phe Phe Ala Gly Thr Tyr Asn Val Asn Gly 
            100                 105                 110         


Gln Ser Pro Lys Glu Cys Leu Arg Leu Trp Leu Ser Asn Gly Ile Gln 
        115                 120                 125             


Ala Pro Asp Val Tyr Cys Val Gly Phe Gln Glu Leu Asp Leu Ser Lys 
    130                 135                 140                 


Glu Ala Phe Phe Phe His Asp Thr Pro Lys Glu Glu Glu Trp Phe Lys 
145                 150                 155                 160 


Ala Val Ser Glu Gly Leu His Pro Asp Ala Lys Tyr Ala Lys Val Lys 
                165                 170                 175     


Leu Ile Arg Leu Val Gly Ile Met Leu Leu Leu Tyr Val Lys Gln Glu 
            180                 185                 190         


His Ala Ala Tyr Ile Ser Glu Val Glu Ala Glu Thr Val Gly Thr Gly 
        195                 200                 205             


Ile Met Gly Arg Met Gly Asn Lys Gly Gly Val Ala Ile Arg Phe Gln 
    210                 215                 220                 


Phe His Asn Thr Ser Ile Cys Val Val Asn Ser His Leu Ala Ala His 
225                 230                 235                 240 


Ile Glu Glu Tyr Glu Arg Arg Asn Gln Asp Tyr Lys Asp Ile Cys Ser 
                245                 250                 255     


Arg Met Gln Phe Cys Gln Pro Asp Pro Ser Leu Pro Pro Leu Thr Ile 
            260                 265                 270         


Ser Asn His Asp Val Ile Leu Trp Leu Gly Asp Leu Asn Tyr Arg Ile 
        275                 280                 285             


Glu Glu Leu Asp Val Glu Lys Val Lys Lys Leu Ile Glu Glu Lys Asp 
    290                 295                 300                 


Phe Gln Met Leu Tyr Ala Tyr Asp Gln Leu Lys Ile Gln Val Ala Ala 
305                 310                 315                 320 


Lys Thr Val Phe Glu Gly Phe Thr Glu Gly Glu Leu Thr Phe Gln Pro 
                325                 330                 335     


Thr Tyr Lys Tyr Asp Thr Gly Ser Asp Asp Trp Asp Thr Ser Glu Lys 
            340                 345                 350         


Cys Arg Ala Pro Ala Trp Cys Asp Arg Ile Leu Trp Lys Gly Lys Asn 
        355                 360                 365             


Ile Thr Gln Leu Ser Tyr Gln Ser His Met Ala Leu Lys Thr Ser Asp 
    370                 375                 380                 


His Lys Pro Val Ser Ser Val Phe Asp Ile Gly Val Arg Val Val Asn 
385                 390                 395                 400 


Asp Glu Leu Tyr Arg Lys Thr Leu Glu Glu Ile Val Arg Ser Leu Asp 
                405                 410                 415     


Lys Met Glu Asn Ala Asn Ile Pro Ser Val Ser Leu Ser Lys Arg Glu 
            420                 425                 430         


Phe Cys Phe Gln Asn Val Lys Tyr Met Gln Leu Lys Val Glu Ser Phe 
        435                 440                 445             


Thr Ile His Asn Gly Gln Val Pro Cys His Phe Glu Phe Ile Asn Lys 
    450                 455                 460                 


Pro Asp Glu Glu Ser Tyr Cys Lys Gln Trp Leu Asn Ala Asn Pro Ser 
465                 470                 475                 480 


Arg Gly Phe Leu Leu Pro Asp Ser Asp Val Glu Ile Asp Leu Glu Leu 
                485                 490                 495     


Phe Val Asn Lys Met Thr Ala Thr Lys Leu Asn Ser Gly Glu Asp Lys 
            500                 505                 510         


Ile Glu Asp Ile Leu Val Leu His Leu Asp Arg Gly Lys Asp Tyr Phe 
        515                 520                 525             


Leu Ser Val Ser Gly Asn Tyr Leu Pro Ser Cys Phe Gly Ser Pro Ile 
    530                 535                 540                 


His Thr Leu Cys Tyr Met Arg Glu Pro Ile Leu Asp Leu Pro Leu Glu 
545                 550                 555                 560 


Thr Ile Ser Glu Leu Thr Leu Met Pro Val Trp Thr Gly Asp Asp Gly 
                565                 570                 575     


Ser Gln Leu Asp Ser Pro Met Glu Ile Pro Lys Glu Leu Trp Met Met 
            580                 585                 590         


Val Asp Tyr Leu Tyr Arg Asn Ala Val Gln Gln Glu Asp Leu Phe Gln 
        595                 600                 605             


Gln Pro Gly Leu Arg Ser Glu Phe Glu His Ile Arg Asp Cys Leu Asp 
    610                 615                 620                 


Thr Gly Met Ile Asp Asn Leu Ser Ala Ser Asn His Ser Val Ala Glu 
625                 630                 635                 640 


Ala Leu Leu Leu Phe Leu Glu Ser Leu Pro Glu Pro Val Ile Cys Tyr 
                645                 650                 655     


Ser Thr Tyr His Asn Cys Leu Glu Cys Ser Gly Asn Tyr Thr Ala Ser 
            660                 665                 670         


Lys Gln Val Ile Ser Thr Leu Pro Ile Phe His Lys Asn Val Phe His 
        675                 680                 685             


Tyr Leu Met Ala Phe Leu Arg Glu Leu Leu Lys Asn Ser Ala Lys Asn 
    690                 695                 700                 


His Leu Asp Glu Asn Ile Leu Ala Ser Ile Phe Gly Ser Leu Leu Leu 
705                 710                 715                 720 


Arg Asn Pro Ala Gly His Gln Lys Leu Asp Met Thr Glu Lys Lys Lys 
                725                 730                 735     


Ala Gln Glu Phe Ile His Gln Phe Leu Cys Asn Pro Leu 
            740                 745                 


<210>  5516
<211>  1189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP5D__Homo_sapiens__NP_001017915

<400>  5516

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Val Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro 
        115                 120                 125             


Arg Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro 
    130                 135                 140                 


Phe Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu 
145                 150                 155                 160 


Ser Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu 
                165                 170                 175     


Pro Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu 
            180                 185                 190         


Ala Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His 
        195                 200                 205             


Leu Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly Glu Val 
    210                 215                 220                 


Ile Arg Thr Leu Pro Ser Leu Glu Ser Leu Gln Arg Leu Phe Asp Gln 
225                 230                 235                 240 


Gln Leu Ser Pro Gly Leu Arg Pro Arg Pro Gln Val Pro Gly Glu Ala 
                245                 250                 255     


Asn Pro Ile Asn Met Val Ser Lys Leu Ser Gln Leu Thr Ser Leu Leu 
            260                 265                 270         


Ser Ser Ile Glu Asp Lys Val Lys Ala Leu Leu His Glu Gly Pro Glu 
        275                 280                 285             


Ser Pro His Arg Pro Ser Leu Ile Pro Pro Val Thr Phe Glu Val Lys 
    290                 295                 300                 


Ala Glu Ser Leu Gly Ile Pro Gln Lys Met Gln Leu Lys Val Asp Val 
305                 310                 315                 320 


Glu Ser Gly Lys Leu Ile Ile Lys Lys Ser Lys Asp Gly Ser Glu Asp 
                325                 330                 335     


Lys Phe Tyr Ser His Lys Lys Ile Leu Gln Leu Ile Lys Ser Gln Lys 
            340                 345                 350         


Phe Leu Asn Lys Leu Val Ile Leu Val Glu Thr Glu Lys Glu Lys Ile 
        355                 360                 365             


Leu Arg Lys Glu Tyr Val Phe Ala Asp Ser Lys Lys Arg Glu Gly Phe 
    370                 375                 380                 


Cys Gln Leu Leu Gln Gln Met Lys Asn Lys His Ser Glu Gln Pro Glu 
385                 390                 395                 400 


Pro Asp Met Ile Thr Ile Phe Ile Gly Thr Trp Asn Met Gly Asn Ala 
                405                 410                 415     


Pro Pro Pro Lys Lys Ile Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly 
            420                 425                 430         


Lys Thr Arg Asp Asp Ser Ala Asp Tyr Ile Pro His Asp Ile Tyr Val 
        435                 440                 445             


Ile Gly Thr Gln Glu Asp Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile 
    450                 455                 460                 


Leu Lys His Ser Leu Gln Glu Ile Thr Ser Val Thr Phe Lys Thr Val 
465                 470                 475                 480 


Ala Ile His Thr Leu Trp Asn Ile Arg Ile Val Val Leu Ala Lys Pro 
                485                 490                 495     


Glu His Glu Asn Arg Ile Ser His Ile Cys Thr Asp Asn Val Lys Thr 
            500                 505                 510         


Gly Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val Ser Phe 
        515                 520                 525             


Met Phe Asn Gly Thr Ser Leu Gly Phe Val Asn Ser His Leu Thr Ser 
    530                 535                 540                 


Gly Ser Glu Lys Lys Leu Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu 
545                 550                 555                 560 


Arg Phe Leu Ala Leu Gly Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr 
                565                 570                 575     


His Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val 
            580                 585                 590         


Asp Leu Pro Thr Trp Glu Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln 
        595                 600                 605             


Gln Gln Tyr Ala Asp Leu Leu Ser His Asp Gln Leu Leu Thr Glu Arg 
    610                 615                 620                 


Arg Glu Gln Lys Val Phe Leu His Phe Glu Glu Glu Glu Ile Thr Phe 
625                 630                 635                 640 


Ala Pro Thr Tyr Arg Phe Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr 
                645                 650                 655     


Thr Lys Gln Lys Ala Thr Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys 
            660                 665                 670         


Asp Arg Val Leu Trp Lys Ser Tyr Pro Leu Val His Val Val Cys Gln 
        675                 680                 685             


Ser Tyr Gly Ser Thr Ser Asp Ile Met Thr Ser Asp His Ser Pro Val 
    690                 695                 700                 


Phe Ala Thr Phe Glu Ala Gly Val Thr Ser Gln Phe Val Ser Lys Asn 
705                 710                 715                 720 


Gly Pro Gly Thr Val Asp Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys 
                725                 730                 735     


Tyr Ala Thr Leu Lys Thr Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe 
            740                 745                 750         


His Ser Ser Cys Leu Glu Ser Phe Val Lys Ser Gln Glu Gly Glu Asn 
        755                 760                 765             


Glu Glu Gly Ser Glu Gly Glu Leu Val Val Lys Phe Gly Glu Thr Leu 
    770                 775                 780                 


Pro Lys Leu Lys Pro Ile Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln 
785                 790                 795                 800 


His Ile Leu Ile Ser Ile Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly 
                805                 810                 815     


Glu Gly Cys Ile Ala Leu Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro 
            820                 825                 830         


Ile Tyr Thr Pro Leu Thr His His Gly Glu Leu Thr Gly His Phe Gln 
        835                 840                 845             


Gly Glu Ile Lys Leu Gln Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu 
    850                 855                 860                 


Tyr Asp Phe Val Lys Thr Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr 
865                 870                 875                 880 


Leu Lys Ser Leu Thr Ser His Asp Pro Met Lys Gln Trp Glu Val Thr 
                885                 890                 895     


Ser Arg Ala Pro Pro Cys Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn 
            900                 905                 910         


Pro Asn Tyr Met Gly Val Gly Pro Phe Gly Pro Pro Met Pro Leu His 
        915                 920                 925             


Val Lys Gln Thr Leu Ser Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr 
    930                 935                 940                 


Asp Gln Pro Pro Lys Asp Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser 
945                 950                 955                 960 


Pro Pro Thr Pro Pro Gly Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu 
                965                 970                 975     


Pro Ser Thr Ala Asn Arg Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg 
            980                 985                 990         


Pro Ser Asp Leu Gly Lys Asn Ala  Gly Asp Thr Leu Pro  Gln Glu Asp 
        995                 1000                 1005             


Leu Pro  Leu Thr Lys Pro Glu  Met Phe Glu Asn Pro  Leu Tyr Gly 
    1010                 1015                 1020             


Ser Leu  Ser Ser Phe Pro Lys  Pro Ala Pro Arg Lys  Asp Gln Glu 
    1025                 1030                 1035             


Ser Pro  Lys Met Pro Arg Lys  Glu Pro Pro Pro Cys  Pro Glu Pro 
    1040                 1045                 1050             


Gly Ile  Leu Ser Pro Ser Ile  Val Leu Thr Lys Ala  Gln Glu Ala 
    1055                 1060                 1065             


Asp Arg  Gly Glu Gly Pro Gly  Lys Gln Val Pro Ala  Pro Arg Leu 
    1070                 1075                 1080             


Arg Ser  Phe Thr Cys Ser Ser  Ser Ala Glu Gly Arg  Ala Ala Gly 
    1085                 1090                 1095             


Gly Asp  Lys Ser Gln Gly Lys  Pro Lys Thr Pro Val  Ser Ser Gln 
    1100                 1105                 1110             


Ala Pro  Val Pro Ala Lys Arg  Pro Ile Lys Pro Ser  Arg Ser Glu 
    1115                 1120                 1125             


Ile Asn  Gln Gln Thr Pro Pro  Thr Pro Thr Pro Arg  Pro Pro Leu 
    1130                 1135                 1140             


Pro Val  Lys Ser Pro Ala Val  Leu His Leu Gln His  Ser Lys Gly 
    1145                 1150                 1155             


Arg Asp  Tyr Arg Asp Asn Thr  Glu Leu Pro His His  Gly Lys His 
    1160                 1165                 1170             


Arg Pro  Glu Glu Gly Pro Pro  Gly Pro Leu Gly Arg  Thr Ala Met 
    1175                 1180                 1185             


Gln 
    


<210>  5517
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP5E__Homo_sapiens__NP_063945

<400>  5517

Met Pro Ser Lys Ala Glu Asn Leu Arg Pro Ser Glu Pro Ala Pro Gln 
1               5                   10                  15      


Pro Pro Glu Gly Arg Thr Leu Gln Gly Gln Leu Pro Gly Ala Pro Pro 
            20                  25                  30          


Ala Gln Arg Ala Gly Ser Pro Pro Asp Ala Pro Gly Ser Glu Ser Pro 
        35                  40                  45              


Ala Leu Ala Cys Ser Thr Pro Ala Thr Pro Ser Gly Glu Asp Pro Pro 
    50                  55                  60                  


Ala Arg Ala Ala Pro Ile Ala Pro Arg Pro Pro Ala Arg Pro Arg Leu 
65                  70                  75                  80  


Glu Arg Ala Leu Ser Leu Asp Asp Lys Gly Trp Arg Arg Arg Arg Phe 
                85                  90                  95      


Arg Gly Ser Gln Glu Asp Leu Glu Ala Arg Asn Gly Thr Ser Pro Ser 
            100                 105                 110         


Arg Gly Ser Val Gln Ser Glu Gly Pro Gly Ala Pro Ala His Ser Cys 
        115                 120                 125             


Ser Pro Pro Cys Leu Ser Thr Ser Leu Gln Glu Ile Pro Lys Ser Arg 
    130                 135                 140                 


Gly Val Leu Ser Ser Glu Arg Gly Ser Pro Ser Ser Gly Gly Asn Pro 
145                 150                 155                 160 


Leu Ser Gly Val Ala Ser Ser Ser Pro Asn Leu Pro His Arg Asp Ala 
                165                 170                 175     


Ala Val Ala Gly Ser Ser Pro Arg Leu Pro Ser Leu Leu Pro Pro Arg 
            180                 185                 190         


Pro Pro Pro Ala Leu Ser Leu Asp Ile Ala Ser Asp Ser Leu Arg Thr 
        195                 200                 205             


Ala Asn Lys Val Asp Ser Asp Leu Ala Asp Tyr Lys Leu Arg Ala Gln 
    210                 215                 220                 


Pro Leu Leu Val Arg Ala His Ser Ser Leu Gly Pro Gly Arg Pro Arg 
225                 230                 235                 240 


Ser Pro Leu Ala Cys Asp Asp Cys Ser Leu Arg Ser Ala Lys Ser Ser 
                245                 250                 255     


Phe Ser Leu Leu Ala Pro Ile Arg Ser Lys Asp Val Arg Ser Arg Ser 
            260                 265                 270         


Tyr Leu Glu Gly Ser Leu Leu Ala Ser Gly Ala Leu Leu Gly Ala Asp 
        275                 280                 285             


Glu Leu Ala Arg Tyr Phe Pro Asp Arg Asn Val Ala Leu Phe Val Ala 
    290                 295                 300                 


Thr Trp Asn Met Gln Gly Gln Lys Glu Leu Pro Pro Ser Leu Asp Glu 
305                 310                 315                 320 


Phe Leu Leu Pro Ala Glu Ala Asp Tyr Ala Gln Asp Leu Tyr Val Ile 
                325                 330                 335     


Gly Val Gln Glu Gly Cys Ser Asp Arg Arg Glu Trp Glu Thr Arg Leu 
            340                 345                 350         


Gln Glu Thr Leu Gly Pro His Tyr Val Leu Leu Ser Ser Ala Ala His 
        355                 360                 365             


Gly Val Leu Tyr Met Ser Leu Phe Ile Arg Arg Asp Leu Ile Trp Phe 
    370                 375                 380                 


Cys Ser Glu Val Glu Cys Ser Thr Val Thr Thr Arg Ile Val Ser Gln 
385                 390                 395                 400 


Ile Lys Thr Lys Gly Ala Leu Gly Ile Ser Phe Thr Phe Phe Gly Thr 
                405                 410                 415     


Ser Phe Leu Phe Ile Thr Ser His Phe Thr Ser Gly Asp Gly Lys Val 
            420                 425                 430         


Ala Glu Arg Leu Leu Asp Tyr Thr Arg Thr Val Gln Ala Leu Val Leu 
        435                 440                 445             


Pro Arg Asn Val Pro Asp Thr Asn Pro Tyr Arg Ser Ser Ala Ala Asp 
    450                 455                 460                 


Val Thr Thr Arg Phe Asp Glu Val Phe Trp Phe Gly Asp Phe Asn Phe 
465                 470                 475                 480 


Arg Leu Ser Gly Gly Arg Thr Val Val Asp Ala Leu Leu Cys Gln Gly 
                485                 490                 495     


Leu Val Val Asp Val Pro Ala Leu Leu Gln His Asp Gln Leu Ile Arg 
            500                 505                 510         


Glu Met Arg Lys Gly Ser Ile Phe Lys Gly Phe Gln Glu Pro Asp Ile 
        515                 520                 525             


His Phe Leu Pro Ser Tyr Lys Phe Asp Ile Gly Lys Asp Thr Tyr Asp 
    530                 535                 540                 


Ser Thr Ser Lys Gln Arg Thr Pro Ser Tyr Thr Asp Arg Val Leu Tyr 
545                 550                 555                 560 


Arg Ser Arg His Lys Gly Asp Ile Cys Pro Val Ser Tyr Ser Ser Cys 
                565                 570                 575     


Pro Gly Ile Lys Thr Ser Asp His Arg Pro Val Tyr Gly Leu Phe Arg 
            580                 585                 590         


Val Lys Val Arg Pro Gly Arg Asp Asn Ile Pro Leu Ala Ala Gly Lys 
        595                 600                 605             


Phe Asp Arg Glu Leu Tyr Leu Leu Gly Ile Lys Arg Arg Ile Ser Lys 
    610                 615                 620                 


Glu Ile Gln Arg Gln Gln Ala Leu Gln Ser Gln Asn Ser Ser Thr Ile 
625                 630                 635                 640 


Cys Ser Val Ser 
                


<210>  5518
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP5F__Homo_sapiens__NP_001230123

<400>  5518

Met Cys His Asp Val Ile Phe Met Ala Trp Leu Lys Gln Gln Phe Ser 
1               5                   10                  15      


Glu Cys Thr Leu Ile Asp Ala Thr His Arg Asp Val Asp Val Leu Leu 
            20                  25                  30          


Leu Leu Ser Asn Ser Ala Tyr Tyr Val Ala Tyr Tyr Asp Asp Glu Val 
        35                  40                  45              


Asp Lys Val Asn Gln Tyr Gln Arg Leu Ser Leu Glu Asn Leu Glu Lys 
    50                  55                  60                  


Ile Glu Ile Gly Pro Glu Pro Thr Leu Phe Gly Lys Pro Lys Phe Ser 
65                  70                  75                  80  


Cys Met Arg Leu His Tyr Arg Tyr Lys Glu Ala Ser Gly Tyr Phe His 
                85                  90                  95      


Thr Leu Arg Ala Val Met Arg Asn Pro Glu Glu Asp Gly Lys Asp Thr 
            100                 105                 110         


Leu Gln Cys Ile Ala Glu Met Leu Gln Ile Thr Lys Gln Ala Met Gly 
        115                 120                 125             


Ser Asp Leu Pro Ile Ile Glu Lys Lys Leu Glu Arg Lys Ser Ser Lys 
    130                 135                 140                 


Pro His Glu Asp Ile Ile Gly Ile Arg Ser Gln Asn Gln Gly Ser Leu 
145                 150                 155                 160 


Ala Gln Gly Lys Asn Phe Leu Met Ser Lys Phe Ser Ser Leu Asn Gln 
                165                 170                 175     


Lys Val Lys Gln Thr Lys Ser Asn Val Asn Ile Gly Asn Leu Arg Lys 
            180                 185                 190         


Leu Gly Asn Phe Thr Lys Pro Glu Met Lys Val Asn Phe Leu Lys Pro 
        195                 200                 205             


Asn Leu Lys Val Asn Leu Trp Lys Ser Asp Ser Ser Leu Glu Thr Met 
    210                 215                 220                 


Glu Asn Thr Gly Val Met Asp Lys Val Gln Ala Glu Ser Asp Gly Asp 
225                 230                 235                 240 


Met Ser Ser Asp Asn Asp Ser Tyr His Ser Asp Glu Phe Leu Thr Asn 
                245                 250                 255     


Ser Lys Ser Asp Glu Asp Arg Gln Leu Ala Asn Ser Leu Glu Ser Val 
            260                 265                 270         


Gly Pro Ile Asp Tyr Val Leu Pro Ser Cys Gly Ile Ile Ala Ser Ala 
        275                 280                 285             


Pro Arg Leu Gly Ser Arg Ser Gln Ser Leu Ser Ser Thr Asp Ser Ser 
    290                 295                 300                 


Val His Ala Pro Ser Glu Ile Thr Val Ala His Gly Ser Gly Leu Gly 
305                 310                 315                 320 


Lys Gly Gln Glu Ser Pro Leu Lys Lys Ser Pro Ser Ala Gly Asp Val 
                325                 330                 335     


His Ile Leu Thr Gly Phe Ala Lys Pro Met Asp Ile Tyr Cys His Arg 
            340                 345                 350         


Phe Val Gln Asp Ala Gln Asn Lys Val Thr His Leu Ser Glu Thr Arg 
        355                 360                 365             


Ser Val Ser Gln Gln Ala Ser Gln Glu Arg Asn Gln Met Thr Asn Gln 
    370                 375                 380                 


Val Ser Asn Glu Thr Gln Ser Glu Ser Thr Glu Gln Thr Pro Ser Arg 
385                 390                 395                 400 


Pro Ser Gln Leu Asp Val Ser Leu Ser Ala Thr Gly Pro Gln Phe Leu 
                405                 410                 415     


Ser Val Glu Pro Ala His Ser Val Ala Ser Gln Lys Thr Pro Thr Ser 
            420                 425                 430         


Ala Ser Ser Met Leu Glu Leu Glu Thr Gly Leu His Val Thr Pro Ser 
        435                 440                 445             


Pro Ser Glu Ser Ser Ser Ser Arg Ala Val Ser Pro Phe Ala Lys Ile 
    450                 455                 460                 


Arg Ser Ser Met Val Gln Val Ala Ser Ile Thr Gln Ala Gly Leu Thr 
465                 470                 475                 480 


His Gly Ile Asn Phe Ala Val Ser Lys Val Gln Lys Ser Pro Pro Glu 
                485                 490                 495     


Pro Glu Ile Ile Asn Gln Val Gln Gln Asn Glu Leu Lys Lys Met Phe 
            500                 505                 510         


Ile Gln Cys Gln Thr Arg Ile Ile Gln Ile 
        515                 520         


<210>  5519
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPP5K__Homo_sapiens__NP_057616

<400>  5519

Met Ser Ser Arg Lys Leu Ser Gly Pro Lys Gly Arg Arg Leu Ser Ile 
1               5                   10                  15      


His Val Val Thr Trp Asn Val Ala Ser Ala Ala Pro Pro Leu Asp Leu 
            20                  25                  30          


Ser Asp Leu Leu Gln Leu Asn Asn Arg Asn Leu Asn Leu Asp Ile Tyr 
        35                  40                  45              


Val Ile Gly Leu Gln Glu Leu Asn Ser Gly Ile Ile Ser Leu Leu Ser 
    50                  55                  60                  


Asp Ala Ala Phe Asn Asp Ser Trp Ser Ser Phe Leu Met Asp Val Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Phe Ile Lys Val Ser His Val Arg Met Gln Gly Ile 
                85                  90                  95      


Leu Leu Leu Val Phe Ala Lys Tyr Gln His Leu Pro Tyr Ile Gln Ile 
            100                 105                 110         


Leu Ser Thr Lys Ser Thr Pro Thr Gly Leu Phe Gly Tyr Trp Gly Asn 
        115                 120                 125             


Lys Gly Gly Val Asn Ile Cys Leu Lys Leu Tyr Gly Tyr Tyr Val Ser 
    130                 135                 140                 


Ile Ile Asn Cys His Leu Pro Pro His Ile Ser Asn Asn Tyr Gln Arg 
145                 150                 155                 160 


Leu Glu His Phe Asp Arg Ile Leu Glu Met Gln Asn Cys Glu Gly Arg 
                165                 170                 175     


Asp Ile Pro Asn Ile Leu Asp His Asp Leu Ile Ile Trp Phe Gly Asp 
            180                 185                 190         


Met Asn Phe Arg Ile Glu Asp Phe Gly Leu His Phe Val Arg Glu Ser 
        195                 200                 205             


Ile Lys Asn Arg Cys Tyr Gly Gly Leu Trp Glu Lys Asp Gln Leu Ser 
    210                 215                 220                 


Ile Ala Lys Lys His Asp Pro Leu Leu Arg Glu Phe Gln Glu Gly Arg 
225                 230                 235                 240 


Leu Leu Phe Pro Pro Thr Tyr Lys Phe Asp Arg Asn Ser Asn Asp Tyr 
                245                 250                 255     


Asp Thr Ser Glu Lys Lys Arg Lys Pro Ala Trp Thr Asp Arg Ile Leu 
            260                 265                 270         


Trp Arg Leu Lys Arg Gln Pro Cys Ala Gly Pro Asp Thr Pro Ile Pro 
        275                 280                 285             


Pro Ala Ser His Phe Ser Leu Ser Leu Arg Gly Tyr Ser Ser His Met 
    290                 295                 300                 


Thr Tyr Gly Ile Ser Asp His Lys Pro Val Ser Gly Thr Phe Asp Leu 
305                 310                 315                 320 


Glu Leu Lys Pro Leu Val Ser Ala Pro Leu Ile Val Leu Met Pro Glu 
                325                 330                 335     


Asp Leu Trp Thr Val Glu Asn Asp Met Met Val Ser Tyr Ser Ser Thr 
            340                 345                 350         


Ser Asp Phe Pro Ser Ser Pro Trp Asp Trp Ile Gly Leu Tyr Lys Val 
        355                 360                 365             


Gly Leu Arg Asp Val Asn Asp Tyr Val Ser Tyr Ala Trp Val Gly Asp 
    370                 375                 380                 


Ser Lys Val Ser Cys Ser Asp Asn Leu Asn Gln Val Tyr Ile Asp Ile 
385                 390                 395                 400 


Ser Asn Ile Pro Thr Thr Glu Asp Glu Phe Leu Leu Cys Tyr Tyr Ser 
                405                 410                 415     


Asn Ser Leu Arg Ser Val Val Gly Ile Ser Arg Pro Phe Gln Ile Pro 
            420                 425                 430         


Pro Gly Ser Leu Arg Glu Asp Pro Leu Gly Glu Ala Gln Pro Gln Ile 
        435                 440                 445             


<210>  5520
<211>  1258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INPPL1__Homo_sapiens__NP_001558

<400>  5520

Met Ala Ser Ala Cys Gly Ala Pro Gly Pro Gly Gly Ala Leu Gly Ser 
1               5                   10                  15      


Gln Ala Pro Ser Trp Tyr His Arg Asp Leu Ser Arg Ala Ala Ala Glu 
            20                  25                  30          


Glu Leu Leu Ala Arg Ala Gly Arg Asp Gly Ser Phe Leu Val Arg Asp 
        35                  40                  45              


Ser Glu Ser Val Ala Gly Ala Phe Ala Leu Cys Val Leu Tyr Gln Lys 
    50                  55                  60                  


His Val His Thr Tyr Arg Ile Leu Pro Asp Gly Glu Asp Phe Leu Ala 
65                  70                  75                  80  


Val Gln Thr Ser Gln Gly Val Pro Val Arg Arg Phe Gln Thr Leu Gly 
                85                  90                  95      


Glu Leu Ile Gly Leu Tyr Ala Gln Pro Asn Gln Gly Leu Val Cys Ala 
            100                 105                 110         


Leu Leu Leu Pro Val Glu Gly Glu Arg Glu Pro Asp Pro Pro Asp Asp 
        115                 120                 125             


Arg Asp Ala Ser Asp Gly Glu Asp Glu Lys Pro Pro Leu Pro Pro Arg 
    130                 135                 140                 


Ser Gly Ser Thr Ser Ile Ser Ala Pro Thr Gly Pro Ser Ser Pro Leu 
145                 150                 155                 160 


Pro Ala Pro Glu Thr Pro Thr Ala Pro Ala Ala Glu Ser Ala Pro Asn 
                165                 170                 175     


Gly Leu Ser Thr Val Ser His Asp Tyr Leu Lys Gly Ser Tyr Gly Leu 
            180                 185                 190         


Asp Leu Glu Ala Val Arg Gly Gly Ala Ser His Leu Pro His Leu Thr 
        195                 200                 205             


Arg Thr Leu Ala Thr Ser Cys Arg Arg Leu His Ser Glu Val Asp Lys 
    210                 215                 220                 


Val Leu Ser Gly Leu Glu Ile Leu Ser Lys Val Phe Asp Gln Gln Ser 
225                 230                 235                 240 


Ser Pro Met Val Thr Arg Leu Leu Gln Gln Gln Asn Leu Pro Gln Thr 
                245                 250                 255     


Gly Glu Gln Glu Leu Glu Ser Leu Val Leu Lys Leu Ser Val Leu Lys 
            260                 265                 270         


Asp Phe Leu Ser Gly Ile Gln Lys Lys Ala Leu Lys Ala Leu Gln Asp 
        275                 280                 285             


Met Ser Ser Thr Ala Pro Pro Ala Pro Gln Pro Ser Thr Arg Lys Ala 
    290                 295                 300                 


Lys Thr Ile Pro Val Gln Ala Phe Glu Val Lys Leu Asp Val Thr Leu 
305                 310                 315                 320 


Gly Asp Leu Thr Lys Ile Gly Lys Ser Gln Lys Phe Thr Leu Ser Val 
                325                 330                 335     


Asp Val Glu Gly Gly Arg Leu Val Leu Leu Arg Arg Gln Arg Asp Ser 
            340                 345                 350         


Gln Glu Asp Trp Thr Thr Phe Thr His Asp Arg Ile Arg Gln Leu Ile 
        355                 360                 365             


Lys Ser Gln Arg Val Gln Asn Lys Leu Gly Val Val Phe Glu Lys Glu 
    370                 375                 380                 


Lys Asp Arg Thr Gln Arg Lys Asp Phe Ile Phe Val Ser Ala Arg Lys 
385                 390                 395                 400 


Arg Glu Ala Phe Cys Gln Leu Leu Gln Leu Met Lys Asn Lys His Ser 
                405                 410                 415     


Lys Gln Asp Glu Pro Asp Met Ile Ser Val Phe Ile Gly Thr Trp Asn 
            420                 425                 430         


Met Gly Ser Val Pro Pro Pro Lys Asn Val Thr Ser Trp Phe Thr Ser 
        435                 440                 445             


Lys Gly Leu Gly Lys Thr Leu Asp Glu Val Thr Val Thr Ile Pro His 
    450                 455                 460                 


Asp Ile Tyr Val Phe Gly Thr Gln Glu Asn Ser Val Gly Asp Arg Glu 
465                 470                 475                 480 


Trp Leu Asp Leu Leu Arg Gly Gly Leu Lys Glu Leu Thr Asp Leu Asp 
                485                 490                 495     


Tyr Arg Pro Ile Ala Met Gln Ser Leu Trp Asn Ile Lys Val Ala Val 
            500                 505                 510         


Leu Val Lys Pro Glu His Glu Asn Arg Ile Ser His Val Ser Thr Ser 
        515                 520                 525             


Ser Val Lys Thr Gly Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val 
    530                 535                 540                 


Gly Val Ser Phe Met Phe Asn Gly Thr Ser Phe Gly Phe Val Asn Cys 
545                 550                 555                 560 


His Leu Thr Ser Gly Asn Glu Lys Thr Ala Arg Arg Asn Gln Asn Tyr 
                565                 570                 575     


Leu Asp Ile Leu Arg Leu Leu Ser Leu Gly Asp Arg Gln Leu Asn Ala 
            580                 585                 590         


Phe Asp Ile Ser Leu Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu 
        595                 600                 605             


Asn Tyr Arg Leu Asp Met Asp Ile Gln Glu Ile Leu Asn Tyr Ile Ser 
    610                 615                 620                 


Arg Lys Glu Phe Glu Pro Leu Leu Arg Val Asp Gln Leu Asn Leu Glu 
625                 630                 635                 640 


Arg Glu Lys His Lys Val Phe Leu Arg Phe Ser Glu Glu Glu Ile Ser 
                645                 650                 655     


Phe Pro Pro Thr Tyr Arg Tyr Glu Arg Gly Ser Arg Asp Thr Tyr Ala 
            660                 665                 670         


Trp His Lys Gln Lys Pro Thr Gly Val Arg Thr Asn Val Pro Ser Trp 
        675                 680                 685             


Cys Asp Arg Ile Leu Trp Lys Ser Tyr Pro Glu Thr His Ile Ile Cys 
    690                 695                 700                 


Asn Ser Tyr Gly Cys Thr Asp Asp Ile Val Thr Ser Asp His Ser Pro 
705                 710                 715                 720 


Val Phe Gly Thr Phe Glu Val Gly Val Thr Ser Gln Phe Ile Ser Lys 
                725                 730                 735     


Lys Gly Leu Ser Lys Thr Ser Asp Gln Ala Tyr Ile Glu Phe Glu Ser 
            740                 745                 750         


Ile Glu Ala Ile Val Lys Thr Ala Ser Arg Thr Lys Phe Phe Ile Glu 
        755                 760                 765             


Phe Tyr Ser Thr Cys Leu Glu Glu Tyr Lys Lys Ser Phe Glu Asn Asp 
    770                 775                 780                 


Ala Gln Ser Ser Asp Asn Ile Asn Phe Leu Lys Val Gln Trp Ser Ser 
785                 790                 795                 800 


Arg Gln Leu Pro Thr Leu Lys Pro Ile Leu Ala Asp Ile Glu Tyr Leu 
                805                 810                 815     


Gln Asp Gln His Leu Leu Leu Thr Val Lys Ser Met Asp Gly Tyr Glu 
            820                 825                 830         


Ser Tyr Gly Glu Cys Val Val Ala Leu Lys Ser Met Ile Gly Ser Thr 
        835                 840                 845             


Ala Gln Gln Phe Leu Thr Phe Leu Ser His Arg Gly Glu Glu Thr Gly 
    850                 855                 860                 


Asn Ile Arg Gly Ser Met Lys Val Arg Val Pro Thr Glu Arg Leu Gly 
865                 870                 875                 880 


Thr Arg Glu Arg Leu Tyr Glu Trp Ile Ser Ile Asp Lys Asp Glu Ala 
                885                 890                 895     


Gly Ala Lys Ser Lys Ala Pro Ser Val Ser Arg Gly Ser Gln Glu Pro 
            900                 905                 910         


Arg Ser Gly Ser Arg Lys Pro Ala Phe Thr Glu Ala Ser Cys Pro Leu 
        915                 920                 925             


Ser Arg Leu Phe Glu Glu Pro Glu Lys Pro Pro Pro Thr Gly Arg Pro 
    930                 935                 940                 


Pro Ala Pro Pro Arg Ala Ala Pro Arg Glu Glu Pro Leu Thr Pro Arg 
945                 950                 955                 960 


Leu Lys Pro Glu Gly Ala Pro Glu Pro Glu Gly Val Ala Ala Pro Pro 
                965                 970                 975     


Pro Lys Asn Ser Phe Asn Asn Pro Ala Tyr Tyr Val Leu Glu Gly Val 
            980                 985                 990         


Pro His Gln Leu Leu Pro Pro Glu  Pro Pro Ser Pro Ala  Arg Ala Pro 
        995                 1000                 1005             


Val Pro  Ser Ala Thr Lys Asn  Lys Val Ala Ile Thr  Val Pro Ala 
    1010                 1015                 1020             


Pro Gln  Leu Gly His His Arg  His Pro Arg Val Gly  Glu Gly Ser 
    1025                 1030                 1035             


Ser Ser  Asp Glu Glu Ser Gly  Gly Thr Leu Pro Pro  Pro Asp Phe 
    1040                 1045                 1050             


Pro Pro  Pro Pro Leu Pro Asp  Ser Ala Ile Phe Leu  Pro Pro Ser 
    1055                 1060                 1065             


Leu Asp  Pro Leu Pro Gly Pro  Val Val Arg Gly Arg  Gly Gly Ala 
    1070                 1075                 1080             


Glu Ala  Arg Gly Pro Pro Pro  Pro Lys Ala His Pro  Arg Pro Pro 
    1085                 1090                 1095             


Leu Pro  Pro Gly Pro Ser Pro  Ala Ser Thr Phe Leu  Gly Glu Val 
    1100                 1105                 1110             


Ala Ser  Gly Asp Asp Arg Ser  Cys Ser Val Leu Gln  Met Ala Lys 
    1115                 1120                 1125             


Thr Leu  Ser Glu Val Asp Tyr  Ala Pro Ala Gly Pro  Ala Arg Ser 
    1130                 1135                 1140             


Ala Leu  Leu Pro Gly Pro Leu  Glu Leu Gln Pro Pro  Arg Gly Leu 
    1145                 1150                 1155             


Pro Ser  Asp Tyr Gly Arg Pro  Leu Ser Phe Pro Pro  Pro Arg Ile 
    1160                 1165                 1170             


Arg Glu  Ser Ile Gln Glu Asp  Leu Ala Glu Glu Ala  Pro Cys Leu 
    1175                 1180                 1185             


Gln Gly  Gly Arg Ala Ser Gly  Leu Gly Glu Ala Gly  Met Ser Ala 
    1190                 1195                 1200             


Trp Leu  Arg Ala Ile Gly Leu  Glu Arg Tyr Glu Glu  Gly Leu Val 
    1205                 1210                 1215             


His Asn  Gly Trp Asp Asp Leu  Glu Phe Leu Ser Asp  Ile Thr Glu 
    1220                 1225                 1230             


Glu Asp  Leu Glu Glu Ala Gly  Val Gln Asp Pro Ala  His Lys Arg 
    1235                 1240                 1245             


Leu Leu  Leu Asp Thr Leu Gln  Leu Ser Lys 
    1250                 1255             


<210>  5521
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSC__Homo_sapiens__NP_001027024

<400>  5521

Met Arg Arg Pro Pro Gly Asn Gly Glu Ala Ala Ser Glu Gly Pro Gly 
1               5                   10                  15      


Gly Trp Gly Leu Trp Gly Val Gln Glu Ser Arg Arg Leu Cys Cys Ala 
            20                  25                  30          


Gly His Asp Arg Cys Lys Gln Ala Leu Leu Gln Ile Gly Ile Asn Met 
        35                  40                  45              


Met Ala Leu Pro Gly Gly Arg His Leu Asp Ser Val Thr Leu Pro Gly 
    50                  55                  60                  


Gln Arg Leu His Leu Met Gln Val Asp Ser Val Gln Arg Trp Met Glu 
65                  70                  75                  80  


Asp Leu Lys Leu Met Thr Glu Cys Glu Cys Met Cys Val Leu Gln Ala 
                85                  90                  95      


Lys Pro Ile Ser Leu Glu Glu Asp Ala Gln Gly Asp Leu Ile Leu Ala 
            100                 105                 110         


Gly Gly Pro Gly Pro Gly Asp Pro Leu Gln Leu Leu Leu Lys Arg Gly 
        115                 120                 125             


Trp Val Ile Ser Thr Glu Leu Arg Arg Ile Gly Gln Lys Leu Ala Gln 
    130                 135                 140                 


Asp Arg Trp Ala Arg Val His Ser Met Ser Val Arg Leu Thr Cys His 
145                 150                 155                 160 


Ala Arg Ser Met Val Ser Glu Tyr Ser Ala Val Ser Arg Asn Ser Leu 
                165                 170                 175     


Lys Glu Met Gly Glu Ile Glu Lys Leu Leu Met Glu Lys Cys Ser Glu 
            180                 185                 190         


Leu Ser Ala Val Thr Glu Arg Cys Leu Gln Val Glu Asn Glu His Val 
        195                 200                 205             


Leu Lys Ser Met Lys Ala Cys Val Ser Glu Thr Leu Ser Met Leu Gly 
    210                 215                 220                 


Gln His Phe Gly Gln Leu Leu Glu Leu Ala Leu Thr Arg Glu Val Gln 
225                 230                 235                 240 


Ala Leu Val Arg Lys Ile Asp Ala Ser Asp Asn Ile Tyr Thr Thr Glu 
                245                 250                 255     


Ser Thr Thr Gly Asn Leu Phe Ser Leu Thr Gln Glu Gly Ala Pro Leu 
            260                 265                 270         


Cys Arg Ile Ile Ala Lys Glu Gly Gly Val Val Ala Leu Phe Lys Val 
        275                 280                 285             


Cys Arg Gln Asp Ser Phe Arg Cys Leu Tyr Pro Gln Ala Leu Arg Thr 
    290                 295                 300                 


Leu Ala Ser Ile Cys Cys Val Glu Glu Gly Val His Gln Leu Glu Lys 
305                 310                 315                 320 


Val Asp Gly Val Leu Cys Leu Ala Asp Ile Leu Thr Asp Asn Ser His 
                325                 330                 335     


Ser Glu Ala Thr Arg Ala Glu Ala Ala Ala Val Val Ala Gln Val Thr 
            340                 345                 350         


Ser Pro His Leu Pro Val Thr Gln His Leu Ser Ser Phe Leu Glu Ser 
        355                 360                 365             


Met Glu Glu Ile Val Thr Ala Leu Val Lys Leu Cys Gln Glu Ala Ser 
    370                 375                 380                 


Ser Gly Glu Val Phe Leu Leu Ala Ser Ala Ala Leu Ala Asn Ile Thr 
385                 390                 395                 400 


Phe Phe Asp Thr Met Ala Cys Glu Met Leu Leu Gln Leu Asn Ala Ile 
                405                 410                 415     


Arg Val Leu Leu Glu Ala Cys Ser Asp Lys Gln Arg Val Asp Thr Pro 
            420                 425                 430         


Tyr Thr Arg Asp Gln Ile Val Thr Ile Leu Ala Asn Met Ser Val Leu 
        435                 440                 445             


Glu Gln Cys Ala Ser Asp Ile Ile Gln Glu Asn Gly Val Gln Leu Ile 
    450                 455                 460                 


Met Gly Met Leu Ser Glu Lys Pro Arg Ser Gly Thr Pro Ala Glu Val 
465                 470                 475                 480 


Ala Ala Cys Glu Arg Val Gln Gln Lys Ala Ala Val Thr Leu Ala Arg 
                485                 490                 495     


Leu Ser Arg Asp Pro Asp Val Ala Arg Glu Ala Val Arg Leu Ser Cys 
            500                 505                 510         


Met Ser Arg Leu Ile Glu Leu Cys Arg Ser Pro Ser Glu Arg Asn Ser 
        515                 520                 525             


Ser Asp Ala Val Leu Val Ala Cys Leu Ala Ala Leu Arg Arg Leu Ala 
    530                 535                 540                 


Gly Val Cys Pro Glu Gly Leu Gln Asp Ser Asp Phe Gln Gln Leu Val 
545                 550                 555                 560 


Gln Pro Arg Leu Val Asp Ser Phe Leu Leu Cys Ser Asn Met Glu Glu 
                565                 570                 575     


Ser Phe Val 
            


<210>  5522
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INS__Homo_sapiens__NP_001278826

<400>  5522

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  5523
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSIG1__Homo_sapiens__NP_005533

<400>  5523

Met Pro Arg Leu His Asp His Phe Trp Ser Cys Ser Cys Ala His Ser 
1               5                   10                  15      


Ala Arg Arg Arg Gly Pro Pro Arg Ala Ser Ala Ala Gly Leu Ala Ala 
            20                  25                  30          


Lys Val Gly Glu Met Ile Asn Val Ser Val Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Ala Ala His Gly Ala Pro Asp Ala Asp Pro Ala Pro Arg Gly Arg Ser 
    50                  55                  60                  


Ala Ala Met Ser Gly Pro Glu Pro Gly Ser Pro Tyr Pro Asn Thr Trp 
65                  70                  75                  80  


His His Arg Leu Leu Gln Arg Ser Leu Val Leu Phe Ser Val Gly Val 
                85                  90                  95      


Val Leu Ala Leu Val Leu Asn Leu Leu Gln Ile Gln Arg Asn Val Thr 
            100                 105                 110         


Leu Phe Pro Glu Glu Val Ile Ala Thr Ile Phe Ser Ser Ala Trp Trp 
        115                 120                 125             


Val Pro Pro Cys Cys Gly Thr Ala Ala Ala Val Val Gly Leu Leu Tyr 
    130                 135                 140                 


Pro Cys Ile Asp Ser His Leu Gly Glu Pro His Lys Phe Lys Arg Glu 
145                 150                 155                 160 


Trp Ala Ser Val Met Arg Cys Ile Ala Val Phe Val Gly Ile Asn His 
                165                 170                 175     


Ala Ser Ala Lys Leu Asp Phe Ala Asn Asn Val Gln Leu Ser Leu Thr 
            180                 185                 190         


Leu Ala Ala Leu Ser Leu Gly Leu Trp Trp Thr Phe Asp Arg Ser Arg 
        195                 200                 205             


Ser Gly Leu Gly Leu Gly Ile Thr Ile Ala Phe Leu Ala Thr Leu Ile 
    210                 215                 220                 


Thr Gln Phe Leu Val Tyr Asn Gly Val Tyr Gln Tyr Thr Ser Pro Asp 
225                 230                 235                 240 


Phe Leu Tyr Ile Arg Ser Trp Leu Pro Cys Ile Phe Phe Ser Gly Gly 
                245                 250                 255     


Val Thr Val Gly Asn Ile Gly Arg Gln Leu Ala Met Gly Val Pro Glu 
            260                 265                 270         


Lys Pro His Ser Asp 
        275         


<210>  5524
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSIG2__Homo_sapiens__XP_011509594

<400>  5524

Met Ala Glu Gly Glu Thr Glu Ser Pro Gly Pro Lys Lys Cys Gly Pro 
1               5                   10                  15      


Tyr Ile Ser Ser Val Thr Ser Gln Ser Val Asn Leu Met Ile Arg Gly 
            20                  25                  30          


Val Val Leu Phe Phe Ile Gly Val Phe Leu Ala Leu Val Leu Asn Leu 
        35                  40                  45              


Leu Gln Ile Gln Arg Asn Val Thr Leu Phe Pro Pro Asp Val Ile Ala 
    50                  55                  60                  


Ser Ile Phe Ser Ser Ala Trp Trp Val Pro Pro Cys Cys Gly Thr Ala 
65                  70                  75                  80  


Ser Ala Val Ile Gly Leu Leu Tyr Pro Cys Ile Asp Arg His Leu Gly 
                85                  90                  95      


Glu Pro His Lys Phe Lys Arg Glu Trp Ser Ser Val Met Arg Cys Val 
            100                 105                 110         


Ala Val Phe Val Gly Ile Asn His Ala Ser Ala Lys Val Asp Phe Asp 
        115                 120                 125             


Asn Asn Ile Gln Leu Ser Leu Thr Leu Ala Ala Leu Ser Ile Gly Leu 
    130                 135                 140                 


Trp Trp Thr Phe Asp Arg Ser Arg Ser Gly Phe Gly Leu Gly Val Gly 
145                 150                 155                 160 


Ile Ala Phe Leu Ala Thr Val Val Thr Gln Leu Leu Val Tyr Asn Gly 
                165                 170                 175     


Val Tyr Gln Tyr Thr Ser Pro Asp Phe Leu Tyr Val Arg Ser Trp Leu 
            180                 185                 190         


Pro Cys Ile Phe Phe Ala Gly Gly Ile Thr Met Gly Asn Ile Gly Arg 
        195                 200                 205             


Gln Leu Ala Met Tyr Glu Cys Lys Val Ile Ala Glu Lys Ser His Gln 
    210                 215                 220                 


Glu 
225 


<210>  5525
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INS-IGF2__Homo_sapiens__NP_001035835

<400>  5525

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Ala Ser 
    50                  55                  60                  


Ala Leu Ser Leu Ser Ser Ser Thr Ser Thr Trp Pro Glu Gly Leu Asp 
65                  70                  75                  80  


Ala Thr Ala Arg Ala Pro Pro Ala Leu Val Val Thr Ala Asn Ile Gly 
                85                  90                  95      


Gln Ala Gly Gly Ser Ser Ser Arg Gln Phe Arg Gln Arg Ala Leu Gly 
            100                 105                 110         


Thr Ser Asp Ser Pro Val Leu Phe Ile His Cys Pro Gly Ala Ala Gly 
        115                 120                 125             


Thr Ala Gln Gly Leu Glu Tyr Arg Gly Arg Arg Val Thr Thr Glu Leu 
    130                 135                 140                 


Val Trp Glu Glu Val Asp Ser Ser Pro Gln Pro Gln Gly Ser Glu Ser 
145                 150                 155                 160 


Leu Pro Ala Gln Pro Pro Ala Gln Pro Ala Pro Gln Pro Glu Pro Gln 
                165                 170                 175     


Gln Ala Arg Glu Pro Ser Pro Glu Val Ser Cys Cys Gly Leu Trp Pro 
            180                 185                 190         


Arg Arg Pro Gln Arg Ser Gln Asn 
        195                 200 


<210>  5526
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSL3__Homo_sapiens__NP_001252516

<400>  5526

Met Asp Pro Arg Leu Pro Ala Trp Ala Leu Val Leu Leu Gly Pro Ala 
1               5                   10                  15      


Leu Val Phe Ala Leu Gly Pro Ala Pro Thr Pro Glu Met Arg Glu Lys 
            20                  25                  30          


Leu Cys Gly His His Phe Val Arg Ala Leu Val Arg Val Cys Gly Gly 
        35                  40                  45              


Pro Arg Trp Ser Thr Glu Ala Arg Arg Pro Ala Thr Gly Gly Asp Gln 
    50                  55                  60                  


Arg Glu Ser His Ser Val Ser Gln Ala Gly Leu Lys Leu Leu Ser Ser 
65                  70                  75                  80  


Ser Asn Pro Pro Thr Leu Thr Phe Gln Ser Val Gly Ile Ser Asp Val 
                85                  90                  95      


Ser Cys Tyr Ser Gly Trp Arg Asp Asp Ile Cys Ser Met Gly Trp Trp 
            100                 105                 110         


Pro Thr Val Ile Ser Arg Trp Asp Leu Ala Cys Ser Pro Cys Pro Arg 
        115                 120                 125             


Pro Leu Thr Ile Thr Ala Thr Thr Val Gln Leu Pro Pro Thr Leu His 
    130                 135                 140                 


Ala Thr Ala Ala Ser Val Ala Val Pro Asn Lys Thr Cys 
145                 150                 155         


<210>  5527
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSL4__Homo_sapiens__NP_002186

<400>  5527

Met Ala Ser Leu Phe Arg Ser Tyr Leu Pro Ala Ile Trp Leu Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Glu Ser Leu Ala Ala Glu Leu Arg Gly Cys Gly 
            20                  25                  30          


Pro Arg Phe Gly Lys His Leu Leu Ser Tyr Cys Pro Met Pro Glu Lys 
        35                  40                  45              


Thr Phe Thr Thr Thr Pro Gly Gly Trp Leu Leu Glu Ser Gly Arg Pro 
    50                  55                  60                  


Lys Glu Met Val Ser Thr Ser Asn Asn Lys Asp Gly Gln Ala Leu Gly 
65                  70                  75                  80  


Thr Thr Ser Glu Phe Ile Pro Asn Leu Ser Pro Glu Leu Lys Lys Pro 
                85                  90                  95      


Leu Ser Glu Gly Gln Pro Ser Leu Lys Lys Ile Ile Leu Ser Arg Lys 
            100                 105                 110         


Lys Arg Ser Gly Arg His Arg Phe Asp Pro Phe Cys Cys Glu Val Ile 
        115                 120                 125             


Cys Asp Asp Gly Thr Ser Val Lys Leu Cys Thr 
    130                 135                 


<210>  5528
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSL6__Homo_sapiens__NP_009110

<400>  5528

Met Pro Arg Leu Leu Arg Leu Ser Leu Leu Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Val Arg Phe Ser Arg Glu Leu Ser Asp Ile Ser Ser Ala Arg Lys Leu 
            20                  25                  30          


Cys Gly Arg Tyr Leu Val Lys Glu Ile Glu Lys Leu Cys Gly His Ala 
        35                  40                  45              


Asn Trp Ser Gln Phe Arg Phe Glu Glu Glu Thr Pro Phe Ser Arg Leu 
    50                  55                  60                  


Ile Ala Gln Ala Ser Glu Lys Val Glu Ala Tyr Ser Pro Tyr Gln Phe 
65                  70                  75                  80  


Glu Ser Pro Gln Thr Ala Ser Pro Ala Arg Gly Arg Gly Thr Asn Pro 
                85                  90                  95      


Val Ser Thr Ser Trp Glu Glu Ala Val Asn Ser Trp Glu Met Gln Ser 
            100                 105                 110         


Leu Pro Glu Tyr Lys Asp Lys Lys Gly Tyr Ser Pro Leu Gly Lys Thr 
        115                 120                 125             


Arg Glu Phe Ser Ser Ser His Asn Ile Asn Val Tyr Ile His Glu Asn 
    130                 135                 140                 


Ala Lys Phe Gln Lys Lys Arg Arg Asn Lys Ile Lys Thr Leu Ser Asn 
145                 150                 155                 160 


Leu Phe Trp Gly His His Pro Gln Arg Lys Arg Arg Gly Tyr Ser Glu 
                165                 170                 175     


Lys Cys Cys Leu Thr Gly Cys Thr Lys Glu Glu Leu Ser Ile Ala Cys 
            180                 185                 190         


Leu Pro Tyr Ile Asp Phe Lys Arg Leu Lys Glu Lys Arg Ser Ser Leu 
        195                 200                 205             


Val Thr Lys Ile Tyr 
    210             


<210>  5529
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSM1__Homo_sapiens__NP_002187

<400>  5529

Met Pro Arg Gly Phe Leu Val Lys Arg Ser Lys Lys Ser Thr Pro Val 
1               5                   10                  15      


Ser Tyr Arg Val Arg Gly Gly Glu Asp Gly Asp Arg Ala Leu Leu Leu 
            20                  25                  30          


Ser Pro Ser Cys Gly Gly Ala Arg Ala Glu Pro Pro Ala Pro Ser Pro 
        35                  40                  45              


Val Pro Gly Pro Leu Pro Pro Pro Pro Pro Ala Glu Arg Ala His Ala 
    50                  55                  60                  


Ala Leu Ala Ala Ala Leu Ala Cys Ala Pro Gly Pro Gln Pro Pro Pro 
65                  70                  75                  80  


Gln Gly Pro Arg Ala Ala His Phe Gly Asn Pro Glu Ala Ala His Pro 
                85                  90                  95      


Ala Pro Leu Tyr Ser Pro Thr Arg Pro Val Ser Arg Glu His Glu Lys 
            100                 105                 110         


His Lys Tyr Phe Glu Arg Ser Phe Asn Leu Gly Ser Pro Val Ser Ala 
        115                 120                 125             


Glu Ser Phe Pro Thr Pro Ala Ala Leu Leu Gly Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ala Ser Gly Ala Gly Gly Gly Gly Thr Cys Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Leu Phe Ala Pro Ala Glu Leu Lys Met Gly Thr Ala Phe Ser Ala Gly 
                165                 170                 175     


Ala Glu Ala Ala Arg Gly Pro Gly Pro Gly Pro Pro Leu Pro Pro Ala 
            180                 185                 190         


Ala Ala Leu Arg Pro Pro Gly Lys Arg Pro Pro Pro Pro Thr Ala Ala 
        195                 200                 205             


Glu Pro Pro Ala Lys Ala Val Lys Ala Pro Gly Ala Lys Lys Pro Lys 
    210                 215                 220                 


Ala Ile Arg Lys Leu His Phe Glu Asp Glu Val Thr Thr Ser Pro Val 
225                 230                 235                 240 


Leu Gly Leu Lys Ile Lys Glu Gly Pro Val Glu Ala Pro Arg Gly Arg 
                245                 250                 255     


Ala Gly Gly Ala Ala Arg Pro Leu Gly Glu Phe Ile Cys Gln Leu Cys 
            260                 265                 270         


Lys Glu Glu Tyr Ala Asp Pro Phe Ala Leu Ala Gln His Lys Cys Ser 
        275                 280                 285             


Arg Ile Val Arg Val Glu Tyr Arg Cys Pro Glu Cys Ala Lys Val Phe 
    290                 295                 300                 


Ser Cys Pro Ala Asn Leu Ala Ser His Arg Arg Trp His Lys Pro Arg 
305                 310                 315                 320 


Pro Ala Pro Ala Ala Ala Arg Ala Pro Glu Pro Glu Ala Ala Ala Arg 
                325                 330                 335     


Ala Glu Ala Arg Glu Ala Pro Gly Gly Gly Ser Asp Arg Asp Thr Pro 
            340                 345                 350         


Ser Pro Gly Gly Val Ser Glu Ser Gly Ser Glu Asp Gly Leu Tyr Glu 
        355                 360                 365             


Cys His His Cys Ala Lys Lys Phe Arg Arg Gln Ala Tyr Leu Arg Lys 
    370                 375                 380                 


His Leu Leu Ala His His Gln Ala Leu Gln Ala Lys Gly Ala Pro Leu 
385                 390                 395                 400 


Ala Pro Pro Ala Glu Asp Leu Leu Ala Leu Tyr Pro Gly Pro Asp Glu 
                405                 410                 415     


Lys Ala Pro Gln Glu Ala Ala Gly Asp Gly Glu Gly Ala Gly Val Leu 
            420                 425                 430         


Gly Leu Ser Ala Ser Ala Glu Cys His Leu Cys Pro Val Cys Gly Glu 
        435                 440                 445             


Ser Phe Ala Ser Lys Gly Ala Gln Glu Arg His Leu Arg Leu Leu His 
    450                 455                 460                 


Ala Ala Gln Val Phe Pro Cys Lys Tyr Cys Pro Ala Thr Phe Tyr Ser 
465                 470                 475                 480 


Ser Pro Gly Leu Thr Arg His Ile Asn Lys Cys His Pro Ser Glu Asn 
                485                 490                 495     


Arg Gln Val Ile Leu Leu Gln Val Pro Val Arg Pro Ala Cys 
            500                 505                 510 


<210>  5530
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSM2__Homo_sapiens__NP_115983

<400>  5530

Met Pro Arg Gly Phe Leu Val Lys Arg Thr Lys Arg Thr Gly Gly Leu 
1               5                   10                  15      


Tyr Arg Val Arg Leu Ala Glu Arg Val Phe Pro Leu Leu Gly Pro Gln 
            20                  25                  30          


Gly Ala Pro Pro Phe Leu Glu Glu Ala Pro Ser Ala Ser Leu Pro Gly 
        35                  40                  45              


Ala Glu Arg Ala Thr Pro Pro Thr Arg Glu Glu Pro Gly Lys Gly Leu 
    50                  55                  60                  


Thr Ala Glu Ala Ala Arg Glu Gln Ser Gly Ser Pro Cys Arg Ala Ala 
65                  70                  75                  80  


Gly Val Ser Pro Gly Thr Gly Gly Arg Glu Gly Ala Glu Trp Arg Ala 
                85                  90                  95      


Gly Gly Arg Glu Gly Pro Gly Pro Ser Pro Ser Pro Ser Pro Ser Pro 
            100                 105                 110         


Ala Lys Pro Ala Gly Ala Glu Leu Arg Arg Ala Phe Leu Glu Arg Cys 
        115                 120                 125             


Leu Ser Ser Pro Val Ser Ala Glu Ser Phe Pro Gly Gly Ala Ala Ala 
    130                 135                 140                 


Val Ala Ala Phe Ser Cys Ser Val Ala Pro Ala Ala Ala Pro Thr Pro 
145                 150                 155                 160 


Gly Glu Gln Phe Leu Leu Pro Leu Arg Ala Pro Phe Pro Glu Pro Ala 
                165                 170                 175     


Leu Gln Pro Asp Pro Ala Pro Leu Ser Ala Ala Leu Gln Ser Leu Lys 
            180                 185                 190         


Arg Ala Ala Gly Gly Glu Arg Arg Gly Lys Ala Pro Thr Asp Cys Ala 
        195                 200                 205             


Ser Gly Pro Ala Ala Ala Gly Ile Lys Lys Pro Lys Ala Met Arg Lys 
    210                 215                 220                 


Leu Ser Phe Ala Asp Glu Val Thr Thr Ser Pro Val Leu Gly Leu Lys 
225                 230                 235                 240 


Ile Lys Glu Glu Glu Pro Gly Ala Pro Ser Arg Gly Leu Gly Gly Ser 
                245                 250                 255     


Arg Thr Pro Leu Gly Glu Phe Ile Cys Gln Leu Cys Lys Glu Gln Tyr 
            260                 265                 270         


Ala Asp Pro Phe Ala Leu Ala Gln His Arg Cys Ser Arg Ile Val Arg 
        275                 280                 285             


Val Glu Tyr Arg Cys Pro Glu Cys Asp Lys Val Phe Ser Cys Pro Ala 
    290                 295                 300                 


Asn Leu Ala Ser His Arg Arg Trp His Lys Pro Arg Pro Ala Ala Ala 
305                 310                 315                 320 


Asn Ala Ala Thr Val Ser Ser Ala Asp Gly Lys Pro Pro Ser Ser Ser 
                325                 330                 335     


Ser Ser Ser Ser Arg Asp Ser Gly Ala Ile Ala Ser Phe Leu Ala Glu 
            340                 345                 350         


Gly Lys Glu Asn Ser Arg Ile Glu Arg Thr Ala Asp Gln His Pro Gln 
        355                 360                 365             


Ala Arg Asp Ser Ser Gly Ala Asp Gln His Pro Asp Ser Ala Pro Arg 
    370                 375                 380                 


Gln Gly Leu Gln Val Leu Thr His Pro Glu Pro Pro Leu Pro Gln Gly 
385                 390                 395                 400 


Pro Tyr Thr Glu Gly Val Leu Gly Arg Arg Val Pro Val Pro Gly Ser 
                405                 410                 415     


Thr Ser Gly Gly Arg Gly Ser Glu Ile Phe Val Cys Pro Tyr Cys His 
            420                 425                 430         


Lys Lys Phe Arg Arg Gln Ala Tyr Leu Arg Lys His Leu Ser Thr His 
        435                 440                 445             


Glu Ala Gly Ser Ala Arg Ala Leu Ala Pro Gly Phe Gly Ser Glu Arg 
    450                 455                 460                 


Gly Ala Pro Leu Ala Phe Ala Cys Pro Leu Cys Gly Ala His Phe Pro 
465                 470                 475                 480 


Thr Ala Asp Ile Arg Glu Lys His Arg Leu Trp His Ala Val Arg Glu 
                485                 490                 495     


Glu Leu Leu Leu Pro Ala Leu Ala Gly Ala Pro Pro Glu Thr Ser Gly 
            500                 505                 510         


Pro Ser Gly Pro Ser Asp Gly Ser Ala Gln Gln Ile Phe Ser Cys Lys 
        515                 520                 525             


His Cys Pro Ser Thr Phe Phe Ser Ser Pro Gly Leu Thr Arg His Ile 
    530                 535                 540                 


Asn Lys Cys His Pro Ser Glu Ser Arg Gln Val Leu Leu Leu Gln Met 
545                 550                 555                 560 


Pro Leu Arg Pro Gly Cys 
                565     


<210>  5531
<211>  1382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSR__Homo_sapiens__NP_000199

<400>  5531

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly 
945                 950                 955                 960 


Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr 
                965                 970                 975     


Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr 
            980                 985                 990         


Ala Ser Ser Asn Pro Glu Tyr Leu  Ser Ala Ser Asp Val  Phe Pro Cys 
        995                 1000                 1005             


Ser Val  Tyr Val Pro Asp Glu  Trp Glu Val Ser Arg  Glu Lys Ile 
    1010                 1015                 1020             


Thr Leu  Leu Arg Glu Leu Gly  Gln Gly Ser Phe Gly  Met Val Tyr 
    1025                 1030                 1035             


Glu Gly  Asn Ala Arg Asp Ile  Ile Lys Gly Glu Ala  Glu Thr Arg 
    1040                 1045                 1050             


Val Ala  Val Lys Thr Val Asn  Glu Ser Ala Ser Leu  Arg Glu Arg 
    1055                 1060                 1065             


Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met Lys Gly  Phe Thr Cys 
    1070                 1075                 1080             


His His  Val Val Arg Leu Leu  Gly Val Val Ser Lys  Gly Gln Pro 
    1085                 1090                 1095             


Thr Leu  Val Val Met Glu Leu  Met Ala His Gly Asp  Leu Lys Ser 
    1100                 1105                 1110             


Tyr Leu  Arg Ser Leu Arg Pro  Glu Ala Glu Asn Asn  Pro Gly Arg 
    1115                 1120                 1125             


Pro Pro  Pro Thr Leu Gln Glu  Met Ile Gln Met Ala  Ala Glu Ile 
    1130                 1135                 1140             


Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Lys Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala His Asp  Phe Thr Val 
    1160                 1165                 1170             


Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp Ile Tyr  Glu Thr Asp 
    1175                 1180                 1185             


Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu Pro Val  Arg Trp Met 
    1190                 1195                 1200             


Ala Pro  Glu Ser Leu Lys Asp  Gly Val Phe Thr Thr  Ser Ser Asp 
    1205                 1210                 1215             


Met Trp  Ser Phe Gly Val Val  Leu Trp Glu Ile Thr  Ser Leu Ala 
    1220                 1225                 1230             


Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu Gln Val  Leu Lys Phe 
    1235                 1240                 1245             


Val Met  Asp Gly Gly Tyr Leu  Asp Gln Pro Asp Asn  Cys Pro Glu 
    1250                 1255                 1260             


Arg Val  Thr Asp Leu Met Arg  Met Cys Trp Gln Phe  Asn Pro Lys 
    1265                 1270                 1275             


Met Arg  Pro Thr Phe Leu Glu  Ile Val Asn Leu Leu  Lys Asp Asp 
    1280                 1285                 1290             


Leu His  Pro Ser Phe Pro Glu  Val Ser Phe Phe His  Ser Glu Glu 
    1295                 1300                 1305             


Asn Lys  Ala Pro Glu Ser Glu  Glu Leu Glu Met Glu  Phe Glu Asp 
    1310                 1315                 1320             


Met Glu  Asn Val Pro Leu Asp  Arg Ser Ser His Cys  Gln Arg Glu 
    1325                 1330                 1335             


Glu Ala  Gly Gly Arg Asp Gly  Gly Ser Ser Leu Gly  Phe Lys Arg 
    1340                 1345                 1350             


Ser Tyr  Glu Glu His Ile Pro  Tyr Thr His Met Asn  Gly Gly Lys 
    1355                 1360                 1365             


Lys Asn  Gly Arg Ile Leu Thr  Leu Pro Arg Ser Asn  Pro Ser 
    1370                 1375                 1380         


<210>  5532
<211>  1297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INSRR__Homo_sapiens__NP_055030

<400>  5532

Met Ala Val Pro Ser Leu Trp Pro Trp Gly Ala Cys Leu Pro Val Ile 
1               5                   10                  15      


Phe Leu Ser Leu Gly Phe Gly Leu Asp Thr Val Glu Val Cys Pro Ser 
            20                  25                  30          


Leu Asp Ile Arg Ser Glu Val Ala Glu Leu Arg Gln Leu Glu Asn Cys 
        35                  40                  45              


Ser Val Val Glu Gly His Leu Gln Ile Leu Leu Met Phe Thr Ala Thr 
    50                  55                  60                  


Gly Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg Leu Thr Gln Val Thr 
65                  70                  75                  80  


Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu Glu Ser Leu Arg Asp 
                85                  90                  95      


Leu Phe Pro Asn Leu Ala Val Ile Arg Gly Thr Arg Leu Phe Leu Gly 
            100                 105                 110         


Tyr Ala Leu Val Ile Phe Glu Met Pro His Leu Arg Asp Val Ala Leu 
        115                 120                 125             


Pro Ala Leu Gly Ala Val Leu Arg Gly Ala Val Arg Val Glu Lys Asn 
    130                 135                 140                 


Gln Glu Leu Cys His Leu Ser Thr Ile Asp Trp Gly Leu Leu Gln Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Asn His Ile Val Gly Asn Lys Leu Gly Glu Glu Cys 
                165                 170                 175     


Ala Asp Val Cys Pro Gly Val Leu Gly Ala Ala Gly Glu Pro Cys Ala 
            180                 185                 190         


Lys Thr Thr Phe Ser Gly His Thr Asp Tyr Arg Cys Trp Thr Ser Ser 
        195                 200                 205             


His Cys Gln Arg Val Cys Pro Cys Pro His Gly Met Ala Cys Thr Ala 
    210                 215                 220                 


Arg Gly Glu Cys Cys His Thr Glu Cys Leu Gly Gly Cys Ser Gln Pro 
225                 230                 235                 240 


Glu Asp Pro Arg Ala Cys Val Ala Cys Arg His Leu Tyr Phe Gln Gly 
                245                 250                 255     


Ala Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr Gln Tyr Glu Ser Trp 
            260                 265                 270         


Arg Cys Val Thr Ala Glu Arg Cys Ala Ser Leu His Ser Val Pro Gly 
        275                 280                 285             


Arg Ala Ser Thr Phe Gly Ile His Gln Gly Ser Cys Leu Ala Gln Cys 
    290                 295                 300                 


Pro Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile Phe Cys His Lys Cys 
305                 310                 315                 320 


Glu Gly Leu Cys Pro Lys Glu Cys Lys Val Gly Thr Lys Thr Ile Asp 
                325                 330                 335     


Ser Ile Gln Ala Ala Gln Asp Leu Val Gly Cys Thr His Val Glu Gly 
            340                 345                 350         


Ser Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn Leu Glu Pro Gln Leu 
        355                 360                 365             


Gln His Ser Leu Gly Leu Val Glu Thr Ile Thr Gly Phe Leu Lys Ile 
    370                 375                 380                 


Lys His Ser Phe Ala Leu Val Ser Leu Gly Phe Phe Lys Asn Leu Lys 
385                 390                 395                 400 


Leu Ile Arg Gly Asp Ala Met Val Asp Gly Asn Tyr Thr Leu Tyr Val 
                405                 410                 415     


Leu Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser Trp Val Ala Ala Gly 
            420                 425                 430         


Leu Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala Phe Asn Pro Arg Leu 
        435                 440                 445             


Cys Leu Glu His Ile Tyr Arg Leu Glu Glu Val Thr Gly Thr Arg Gly 
    450                 455                 460                 


Arg Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr Asn Gly Asp Arg Ala 
465                 470                 475                 480 


Ala Cys Gln Thr Arg Thr Leu Arg Phe Val Ser Asn Val Thr Glu Ala 
                485                 490                 495     


Asp Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu Pro Leu Glu Ala Arg 
            500                 505                 510         


Asp Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu Ser Pro Phe Gln Asn 
        515                 520                 525             


Ala Thr Glu His Val Gly Pro Asp Ala Cys Gly Thr Gln Ser Trp Asn 
    530                 535                 540                 


Leu Leu Asp Val Glu Leu Pro Leu Ser Arg Thr Gln Glu Pro Gly Val 
545                 550                 555                 560 


Thr Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr Ala Val Phe Val Arg 
                565                 570                 575     


Ala Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro His Gln Gly Ala Gln 
            580                 585                 590         


Ser Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala Ala Pro Thr Val Pro 
        595                 600                 605             


Gln Asp Val Ile Ser Thr Ser Asn Ser Ser Ser His Leu Leu Val Arg 
    610                 615                 620                 


Trp Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu Thr Tyr Tyr Leu Val 
625                 630                 635                 640 


Leu Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu Tyr Leu Asn Asp Tyr 
                645                 650                 655     


Cys His Arg Gly Leu Arg Leu Pro Thr Ser Asn Asn Asp Pro Arg Phe 
            660                 665                 670         


Asp Gly Glu Asp Gly Asp Pro Glu Ala Glu Met Glu Ser Asp Cys Cys 
        675                 680                 685             


Pro Cys Gln His Pro Pro Pro Gly Gln Val Leu Pro Pro Leu Glu Ala 
    690                 695                 700                 


Gln Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn Phe Leu His Asn Ala 
705                 710                 715                 720 


Ile Thr Ile Pro Ile Ser Pro Trp Lys Val Thr Ser Ile Asn Lys Ser 
                725                 730                 735     


Pro Gln Arg Asp Ser Gly Arg His Arg Arg Ala Ala Gly Pro Leu Arg 
            740                 745                 750         


Leu Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln Glu Asp Lys Val Pro 
        755                 760                 765             


Arg Glu Arg Ala Val Leu Ser Gly Leu Arg His Phe Thr Glu Tyr Arg 
    770                 775                 780                 


Ile Asp Ile His Ala Cys Asn His Ala Ala His Thr Val Gly Cys Ser 
785                 790                 795                 800 


Ala Ala Thr Phe Val Phe Ala Arg Thr Met Pro His Arg Glu Ala Asp 
                805                 810                 815     


Gly Ile Pro Gly Lys Val Ala Trp Glu Ala Ser Ser Lys Asn Ser Val 
            820                 825                 830         


Leu Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn Gly Leu Ile Leu Lys 
        835                 840                 845             


Tyr Glu Ile Lys Tyr Arg Arg Leu Gly Glu Glu Ala Thr Val Leu Cys 
    850                 855                 860                 


Val Ser Arg Leu Arg Tyr Ala Lys Phe Gly Gly Val His Leu Ala Leu 
865                 870                 875                 880 


Leu Pro Pro Gly Asn Tyr Ser Ala Arg Val Arg Ala Thr Ser Leu Ala 
                885                 890                 895     


Gly Asn Gly Ser Trp Thr Asp Ser Val Ala Phe Tyr Ile Leu Gly Pro 
            900                 905                 910         


Glu Glu Glu Asp Ala Gly Gly Leu His Val Leu Leu Thr Ala Thr Pro 
        915                 920                 925             


Val Gly Leu Thr Leu Leu Ile Val Leu Ala Ala Leu Gly Phe Phe Tyr 
    930                 935                 940                 


Gly Lys Lys Arg Asn Arg Thr Leu Tyr Ala Ser Val Asn Pro Glu Tyr 
945                 950                 955                 960 


Phe Ser Ala Ser Asp Met Tyr Val Pro Asp Glu Trp Glu Val Pro Arg 
                965                 970                 975     


Glu Gln Ile Ser Ile Ile Arg Glu Leu Gly Gln Gly Ser Phe Gly Met 
            980                 985                 990         


Val Tyr Glu Gly Leu Ala Arg Gly  Leu Glu Ala Gly Glu  Glu Ser Thr 
        995                 1000                 1005             


Pro Val  Ala Leu Lys Thr Val  Asn Glu Leu Ala Ser  Pro Arg Glu 
    1010                 1015                 1020             


Cys Ile  Glu Phe Leu Lys Glu  Ala Ser Val Met Lys  Ala Phe Lys 
    1025                 1030                 1035             


Cys His  His Val Val Arg Leu  Leu Gly Val Val Ser  Gln Gly Gln 
    1040                 1045                 1050             


Pro Thr  Leu Val Ile Met Glu  Leu Met Thr Arg Gly  Asp Leu Lys 
    1055                 1060                 1065             


Ser His  Leu Arg Ser Leu Arg  Pro Glu Ala Glu Asn  Asn Pro Gly 
    1070                 1075                 1080             


Leu Pro  Gln Pro Ala Leu Gly  Glu Met Ile Gln Met  Ala Gly Glu 
    1085                 1090                 1095             


Ile Ala  Asp Gly Met Ala Tyr  Leu Ala Ala Asn Lys  Phe Val His 
    1100                 1105                 1110             


Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val Ser Gln  Asp Phe Thr 
    1115                 1120                 1125             


Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg Asp Val  Tyr Glu Thr 
    1130                 1135                 1140             


Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu Leu Pro  Val Arg Trp 
    1145                 1150                 1155             


Met Ala  Pro Glu Ser Leu Lys  Asp Gly Ile Phe Thr  Thr His Ser 
    1160                 1165                 1170             


Asp Val  Trp Ser Phe Gly Val  Val Leu Trp Glu Ile  Val Thr Leu 
    1175                 1180                 1185             


Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn Glu Gln  Val Leu Lys 
    1190                 1195                 1200             


Phe Val  Met Asp Gly Gly Val  Leu Glu Glu Leu Glu  Gly Cys Pro 
    1205                 1210                 1215             


Leu Gln  Leu Gln Glu Leu Met  Ser Arg Cys Trp Gln  Pro Asn Pro 
    1220                 1225                 1230             


Arg Leu  Arg Pro Ser Phe Thr  His Ile Leu Asp Ser  Ile Gln Glu 
    1235                 1240                 1245             


Glu Leu  Arg Pro Ser Phe Arg  Leu Leu Ser Phe Tyr  Tyr Ser Pro 
    1250                 1255                 1260             


Glu Cys  Arg Gly Ala Arg Gly  Ser Leu Pro Thr Thr  Asp Ala Glu 
    1265                 1270                 1275             


Pro Asp  Ser Ser Pro Thr Pro  Arg Asp Cys Ser Pro  Gln Asn Gly 
    1280                 1285                 1290             


Gly Pro  Gly His 
    1295         


<210>  5533
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS12__Homo_sapiens__NP_001135943

<400>  5533

Met Ala Ala Thr Val Asn Leu Glu Leu Asp Pro Ile Phe Leu Lys Ala 
1               5                   10                  15      


Leu Gly Phe Leu His Ser Lys Ser Lys Asp Ser Ala Glu Lys Leu Lys 
            20                  25                  30          


Ala Leu Leu Asp Glu Ser Leu Ala Arg Gly Ile Asp Ser Ser Tyr Arg 
        35                  40                  45              


Pro Ser Gln Lys Asp Val Glu Pro Pro Lys Ile Ser Ser Thr Lys Asn 
    50                  55                  60                  


Ile Ser Ile Lys Gln Glu Pro Lys Ile Ser Ser Ser Leu Pro Ser Gly 
65                  70                  75                  80  


Asn Asn Asn Gly Lys Val Leu Thr Thr Glu Lys Val Lys Lys Glu Ala 
                85                  90                  95      


Glu Lys Arg Pro Ala Asp Lys Met Lys Ser Asp Ile Thr Glu Gly Val 
            100                 105                 110         


Asp Ile Pro Lys Lys Pro Arg Leu Glu Lys Pro Glu Thr Gln Ser Ser 
        115                 120                 125             


Pro Ile Thr Val Gln Ser Ser Lys Asp Leu Pro Met Ala Asp Leu Ser 
    130                 135                 140                 


Ser Phe Glu Glu Thr Ser Ala Asp Asp Phe Ala Met Glu Met Gly Leu 
145                 150                 155                 160 


Ala Cys Val Val Cys Arg Gln Met Met Val Ala Ser Gly Asn Gln Leu 
                165                 170                 175     


Val Glu Cys Gln Glu Cys His Asn Leu Tyr His Arg Asp Cys His Lys 
            180                 185                 190         


Pro Gln Val Thr Asp Lys Glu Ala Asn Asp Pro Arg Leu Val Trp Tyr 
        195                 200                 205             


Cys Ala Arg Cys Thr Arg Gln Met Lys Arg Met Ala Gln Lys Thr Gln 
    210                 215                 220                 


Lys Pro Pro Gln Lys Pro Ala Pro Ala Val Val Ser Val Thr Pro Ala 
225                 230                 235                 240 


Val Lys Asp Pro Leu Val Lys Lys Pro Glu Thr Lys Leu Lys Gln Glu 
                245                 250                 255     


Thr Thr Phe Leu Ala Phe Lys Arg Thr Glu Val Lys Thr Ser Thr Val 
            260                 265                 270         


Ile Ser Gly Asn Ser Ser Ser Ala Ser Val Ser Ser Ser Val Thr Ser 
        275                 280                 285             


Gly Leu Thr Gly Trp Ala Ala Phe Ala Ala Lys Thr Ser Ser Ala Gly 
    290                 295                 300                 


Pro Ser Thr Ala Lys Leu Ser Ser Thr Thr Gln Asn Asn Thr Gly Lys 
305                 310                 315                 320 


Pro Ala Thr Ser Ser Ala Asn Gln Lys Pro Val Gly Leu Thr Gly Leu 
                325                 330                 335     


Ala Thr Ser Ser Lys Gly Gly Ile Gly Ser Lys Ile Gly Ser Asn Asn 
            340                 345                 350         


Ser Thr Thr Pro Thr Val Pro Leu Lys Pro Pro Pro Pro Leu Thr Leu 
        355                 360                 365             


Gly Lys Thr Gly Leu Ser Arg Ser Val Ser Cys Asp Asn Val Ser Lys 
    370                 375                 380                 


Val Gly Leu Pro Ser Pro Ser Ser Leu Val Pro Gly Ser Ser Ser Gln 
385                 390                 395                 400 


Leu Ser Gly Asn Gly Asn Ser Gly Thr Ser Gly Pro Ser Gly Ser Thr 
                405                 410                 415     


Thr Ser Lys Thr Thr Ser Glu Ser Ser Ser Ser Pro Ser Ala Ser Leu 
            420                 425                 430         


Lys Gly Pro Thr Ser Gln Glu Ser Gln Leu Asn Ala Met Lys Arg Leu 
        435                 440                 445             


Gln Met Val Lys Lys Lys Ala Ala Gln Lys Lys Leu Lys Lys 
    450                 455                 460         


<210>  5534
<211>  2190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS1__Homo_sapiens__NP_001073922

<400>  5534

Met Asn Arg Ala Lys Pro Thr Thr Val Arg Arg Pro Ser Ala Ala Ala 
1               5                   10                  15      


Lys Pro Ser Gly His Pro Pro Pro Gly Asp Phe Ile Ala Leu Gly Ser 
            20                  25                  30          


Lys Gly Gln Ala Asn Glu Ser Lys Thr Ala Ser Thr Leu Leu Lys Pro 
        35                  40                  45              


Ala Pro Ser Gly Leu Pro Ser Glu Arg Lys Arg Asp Ala Ala Ala Ala 
    50                  55                  60                  


Leu Ser Ser Ala Ser Ala Leu Thr Gly Leu Thr Lys Arg Pro Lys Leu 
65                  70                  75                  80  


Ser Ser Thr Pro Pro Leu Ser Ala Leu Gly Arg Leu Ala Glu Ala Ala 
                85                  90                  95      


Val Ala Glu Lys Arg Ala Ile Ser Pro Ser Ile Lys Glu Pro Ser Val 
            100                 105                 110         


Val Pro Ile Glu Val Leu Pro Thr Val Leu Leu Asp Glu Ile Glu Ala 
        115                 120                 125             


Ala Glu Leu Glu Gly Asn Asp Asp Arg Ile Glu Gly Val Leu Cys Gly 
    130                 135                 140                 


Ala Val Lys Gln Leu Lys Val Thr Arg Ala Lys Pro Asp Ser Thr Leu 
145                 150                 155                 160 


Tyr Leu Ser Leu Met Tyr Leu Ala Lys Ile Lys Pro Asn Ile Phe Ala 
                165                 170                 175     


Thr Glu Gly Val Ile Glu Ala Leu Cys Ser Leu Leu Arg Arg Asp Ala 
            180                 185                 190         


Ser Ile Asn Phe Lys Ala Lys Gly Asn Ser Leu Val Ser Val Leu Ala 
        195                 200                 205             


Cys Asn Leu Leu Met Ala Ala Tyr Glu Glu Asp Glu Asn Trp Pro Glu 
    210                 215                 220                 


Ile Phe Val Lys Val Tyr Ile Glu Asp Ser Leu Gly Glu Arg Ile Trp 
225                 230                 235                 240 


Val Asp Ser Pro His Cys Lys Thr Phe Val Asp Asn Ile Gln Thr Ala 
                245                 250                 255     


Phe Asn Thr Arg Met Pro Pro Arg Ser Val Leu Leu Gln Gly Glu Ala 
            260                 265                 270         


Gly Arg Val Ala Gly Asp Leu Gly Ala Gly Ser Ser Pro His Pro Ser 
        275                 280                 285             


Leu Thr Glu Glu Glu Asp Ser Gln Thr Glu Leu Leu Ile Ala Glu Glu 
    290                 295                 300                 


Lys Leu Ser Pro Glu Gln Glu Gly Gln Leu Met Pro Arg Tyr Glu Glu 
305                 310                 315                 320 


Leu Ala Glu Ser Val Glu Glu Tyr Val Leu Asp Met Leu Arg Asp Gln 
                325                 330                 335     


Leu Asn Arg Arg Gln Pro Ile Asp Asn Val Ser Arg Asn Leu Leu Arg 
            340                 345                 350         


Leu Leu Thr Ser Thr Cys Gly Tyr Lys Glu Val Arg Leu Leu Ala Val 
        355                 360                 365             


Gln Lys Leu Glu Met Trp Leu Gln Asn Pro Lys Leu Thr Arg Pro Ala 
    370                 375                 380                 


Gln Asp Leu Leu Met Ser Val Cys Met Asn Cys Asn Thr His Gly Ser 
385                 390                 395                 400 


Glu Asp Met Asp Val Ile Ser His Leu Ile Lys Ile Arg Leu Lys Pro 
                405                 410                 415     


Lys Val Leu Leu Asn His Phe Met Leu Cys Ile Arg Glu Leu Leu Ser 
            420                 425                 430         


Ala His Lys Asp Asn Leu Gly Thr Thr Ile Lys Leu Val Ile Phe Asn 
        435                 440                 445             


Glu Leu Ser Ser Ala Arg Asn Pro Asn Asn Met Gln Val Leu Tyr Thr 
    450                 455                 460                 


Ala Leu Gln His Ser Ser Glu Leu Ala Pro Lys Phe Leu Ala Met Val 
465                 470                 475                 480 


Phe Gln Asp Leu Leu Thr Asn Lys Asp Asp Tyr Leu Arg Ala Ser Arg 
                485                 490                 495     


Ala Leu Leu Arg Glu Ile Ile Lys Gln Thr Lys His Glu Ile Asn Phe 
            500                 505                 510         


Gln Ala Phe Cys Leu Gly Leu Met Gln Glu Arg Lys Glu Pro Gln Tyr 
        515                 520                 525             


Leu Glu Met Glu Phe Lys Glu Arg Phe Val Val His Ile Thr Asp Val 
    530                 535                 540                 


Leu Ala Val Ser Met Met Leu Gly Ile Thr Ala Gln Val Lys Glu Ala 
545                 550                 555                 560 


Gly Ile Ala Trp Asp Lys Gly Glu Lys Arg Asn Leu Glu Val Leu Arg 
                565                 570                 575     


Ser Phe Gln Asn Gln Ile Ala Ala Ile Gln Arg Asp Ala Val Trp Trp 
            580                 585                 590         


Leu His Thr Val Val Pro Ser Ile Ser Lys Leu Ala Pro Lys Asp Tyr 
        595                 600                 605             


Val His Cys Leu His Lys Val Leu Phe Thr Glu Gln Pro Glu Thr Tyr 
    610                 615                 620                 


Tyr Lys Trp Asp Asn Trp Pro Pro Glu Ser Asp Arg Asn Phe Phe Leu 
625                 630                 635                 640 


Arg Leu Cys Ser Glu Val Pro Ile Leu Glu Asp Thr Leu Met Arg Ile 
                645                 650                 655     


Leu Val Ile Gly Leu Ser Arg Glu Leu Pro Leu Gly Pro Ala Asp Ala 
            660                 665                 670         


Met Glu Leu Ala Asp His Leu Val Lys Arg Ala Ala Ala Val Gln Ala 
        675                 680                 685             


Asp Asp Val Glu Val Leu Lys Val Gly Arg Thr Gln Leu Ile Asp Ala 
    690                 695                 700                 


Val Leu Asn Leu Cys Thr Tyr His His Pro Glu Asn Ile Gln Leu Pro 
705                 710                 715                 720 


Pro Gly Tyr Gln Pro Pro Asn Leu Ala Ile Ser Thr Leu Tyr Trp Lys 
                725                 730                 735     


Ala Trp Pro Leu Leu Leu Val Val Ala Ala Phe Asn Pro Glu Asn Ile 
            740                 745                 750         


Gly Leu Ala Ala Trp Glu Glu Tyr Pro Thr Leu Lys Met Leu Met Glu 
        755                 760                 765             


Met Val Met Thr Asn Asn Tyr Ser Tyr Pro Pro Cys Thr Leu Thr Asp 
    770                 775                 780                 


Glu Glu Thr Arg Thr Glu Met Leu Asn Arg Glu Leu Gln Thr Ala Gln 
785                 790                 795                 800 


Arg Glu Lys Gln Glu Ile Leu Ala Phe Glu Gly His Leu Ala Ala Ala 
                805                 810                 815     


Ser Thr Lys Gln Thr Ile Thr Glu Ser Ser Ser Leu Leu Leu Ser Gln 
            820                 825                 830         


Leu Thr Ser Leu Asp Pro Gln Gly Pro Pro Arg Arg Pro Pro Pro His 
        835                 840                 845             


Ile Leu Asp Gln Val Lys Ser Leu Asn Gln Ser Leu Arg Leu Gly His 
    850                 855                 860                 


Leu Leu Cys Arg Ser Arg Asn Pro Asp Phe Leu Leu His Ile Ile Gln 
865                 870                 875                 880 


Arg Gln Ala Ser Ser Gln Ser Met Pro Trp Leu Ala Asp Leu Val Gln 
                885                 890                 895     


Ser Ser Glu Gly Ser Leu Asp Val Leu Pro Val Gln Cys Leu Cys Glu 
            900                 905                 910         


Phe Leu Leu His Asp Ala Val Asp Asp Ala Ala Ser Gly Glu Glu Asp 
        915                 920                 925             


Asp Glu Gly Glu Ser Lys Glu Gln Lys Ala Lys Lys Arg Gln Arg Gln 
    930                 935                 940                 


Gln Lys Gln Arg Gln Leu Leu Gly Arg Leu Gln Asp Leu Leu Leu Gly 
945                 950                 955                 960 


Pro Lys Ala Asp Glu Gln Thr Thr Cys Glu Val Leu Asp Tyr Phe Leu 
                965                 970                 975     


Arg Arg Leu Gly Ser Ser Gln Val Ala Ser Arg Val Leu Ala Met Lys 
            980                 985                 990         


Gly Leu Ser Leu Val Leu Ser Glu  Gly Ser Leu Arg Asp  Gly Glu Glu 
        995                 1000                 1005             


Lys Glu  Pro Pro Met Glu Glu  Asp Val Gly Asp Thr  Asp Val Leu 
    1010                 1015                 1020             


Gln Gly  Tyr Gln Trp Leu Leu  Arg Asp Leu Pro Arg  Leu Pro Leu 
    1025                 1030                 1035             


Phe Asp  Ser Val Arg Ser Thr  Thr Ala Leu Ala Leu  Gln Gln Ala 
    1040                 1045                 1050             


Ile His  Met Glu Thr Asp Pro  Gln Thr Ile Ser Ala  Tyr Leu Ile 
    1055                 1060                 1065             


Tyr Leu  Ser Gln His Thr Pro  Val Glu Glu Gln Ala  Gln His Ser 
    1070                 1075                 1080             


Asp Leu  Ala Leu Asp Val Ala  Arg Leu Val Val Glu  Arg Ser Thr 
    1085                 1090                 1095             


Ile Met  Ser His Leu Phe Ser  Lys Leu Ser Pro Ser  Ala Ala Ser 
    1100                 1105                 1110             


Asp Ala  Val Leu Ser Ala Leu  Leu Ser Ile Phe Ser  Arg Tyr Val 
    1115                 1120                 1125             


Arg Arg  Met Arg Gln Ser Lys  Glu Gly Glu Glu Val  Tyr Ser Trp 
    1130                 1135                 1140             


Ser Glu  Ser Gln Asp Gln Val  Phe Leu Arg Trp Ser  Ser Gly Glu 
    1145                 1150                 1155             


Thr Ala  Thr Met His Ile Leu  Val Val His Ala Met  Val Ile Leu 
    1160                 1165                 1170             


Leu Thr  Leu Gly Pro Pro Arg  Ala Asp Asp Ser Glu  Phe Gln Ala 
    1175                 1180                 1185             


Leu Leu  Asp Ile Trp Phe Pro  Glu Glu Lys Pro Leu  Pro Thr Ala 
    1190                 1195                 1200             


Phe Leu  Val Asp Thr Ser Glu  Glu Ala Leu Leu Leu  Pro Asp Trp 
    1205                 1210                 1215             


Leu Lys  Leu Arg Met Ile Arg  Ser Glu Val Leu Arg  Leu Val Asp 
    1220                 1225                 1230             


Ala Ala  Leu Gln Asp Leu Glu  Pro Gln Gln Leu Leu  Leu Phe Val 
    1235                 1240                 1245             


Gln Ser  Phe Gly Ile Pro Val  Ser Ser Met Ser Lys  Leu Leu Gln 
    1250                 1255                 1260             


Phe Leu  Asp Gln Ala Val Ala  His Asp Pro Gln Thr  Leu Glu Gln 
    1265                 1270                 1275             


Asn Ile  Met Asp Lys Asn Tyr  Met Ala His Leu Val  Glu Val Gln 
    1280                 1285                 1290             


His Glu  Arg Gly Ala Ser Gly  Gly Gln Thr Phe His  Ser Leu Leu 
    1295                 1300                 1305             


Thr Ala  Ser Leu Pro Pro Arg  Arg Asp Ser Thr Glu  Ala Pro Lys 
    1310                 1315                 1320             


Pro Lys  Ser Ser Pro Glu Gln  Pro Ile Gly Gln Gly  Arg Ile Arg 
    1325                 1330                 1335             


Val Gly  Thr Gln Leu Arg Val  Leu Gly Pro Glu Asp  Asp Leu Ala 
    1340                 1345                 1350             


Gly Met  Phe Leu Gln Ile Phe  Pro Leu Ser Pro Asp  Pro Arg Trp 
    1355                 1360                 1365             


Gln Ser  Ser Ser Pro Arg Pro  Val Ala Leu Ala Leu  Gln Gln Ala 
    1370                 1375                 1380             


Leu Gly  Gln Glu Leu Ala Arg  Val Val Gln Gly Ser  Pro Glu Val 
    1385                 1390                 1395             


Pro Gly  Ile Thr Val Arg Val  Leu Gln Ala Leu Ala  Thr Leu Leu 
    1400                 1405                 1410             


Ser Ser  Pro His Gly Gly Ala  Leu Val Met Ser Met  His Arg Ser 
    1415                 1420                 1425             


His Phe  Leu Ala Cys Pro Leu  Leu Arg Gln Leu Cys  Gln Tyr Gln 
    1430                 1435                 1440             


Arg Cys  Val Pro Gln Asp Thr  Gly Phe Ser Ser Leu  Phe Leu Lys 
    1445                 1450                 1455             


Val Leu  Leu Gln Met Leu Gln  Trp Leu Asp Ser Pro  Gly Val Glu 
    1460                 1465                 1470             


Gly Gly  Pro Leu Arg Ala Gln  Leu Arg Met Leu Ala  Ser Gln Ala 
    1475                 1480                 1485             


Ser Ala  Gly Arg Arg Leu Ser  Asp Val Arg Gly Gly  Leu Leu Arg 
    1490                 1495                 1500             


Leu Ala  Glu Ala Leu Ala Phe  Arg Gln Asp Leu Glu  Val Val Ser 
    1505                 1510                 1515             


Ser Thr  Val Arg Ala Val Ile  Ala Thr Leu Arg Ser  Gly Glu Gln 
    1520                 1525                 1530             


Cys Ser  Val Glu Pro Asp Leu  Ile Ser Lys Val Leu  Gln Gly Leu 
    1535                 1540                 1545             


Ile Glu  Val Arg Ser Pro His  Leu Glu Glu Leu Leu  Thr Ala Phe 
    1550                 1555                 1560             


Phe Ser  Ala Thr Ala Asp Ala  Ala Ser Pro Phe Pro  Ala Cys Lys 
    1565                 1570                 1575             


Pro Val  Val Val Val Ser Ser  Leu Leu Leu Gln Glu  Glu Glu Pro 
    1580                 1585                 1590             


Leu Ala  Gly Gly Lys Pro Gly  Ala Asp Gly Gly Ser  Leu Glu Ala 
    1595                 1600                 1605             


Val Arg  Leu Gly Pro Ser Ser  Gly Leu Leu Val Asp  Trp Leu Glu 
    1610                 1615                 1620             


Met Leu  Asp Pro Glu Val Val  Ser Ser Cys Pro Asp  Leu Gln Leu 
    1625                 1630                 1635             


Arg Leu  Leu Phe Ser Arg Arg  Lys Gly Lys Gly Gln  Ala Gln Val 
    1640                 1645                 1650             


Pro Ser  Phe Arg Pro Tyr Leu  Leu Thr Leu Phe Thr  His Gln Ser 
    1655                 1660                 1665             


Ser Trp  Pro Thr Leu His Gln  Cys Ile Arg Val Leu  Leu Gly Lys 
    1670                 1675                 1680             


Ser Arg  Glu Gln Arg Phe Asp  Pro Ser Ala Ser Leu  Asp Phe Leu 
    1685                 1690                 1695             


Trp Ala  Cys Ile His Val Pro  Arg Ile Trp Gln Gly  Arg Asp Gln 
    1700                 1705                 1710             


Arg Thr  Pro Gln Lys Arg Arg  Glu Glu Leu Val Leu  Arg Val Gln 
    1715                 1720                 1725             


Gly Pro  Glu Leu Ile Ser Leu  Val Glu Leu Ile Leu  Ala Glu Ala 
    1730                 1735                 1740             


Glu Thr  Arg Ser Gln Asp Gly  Asp Thr Ala Ala Cys  Ser Leu Ile 
    1745                 1750                 1755             


Gln Ala  Arg Leu Pro Leu Leu  Leu Ser Cys Cys Cys  Gly Asp Asp 
    1760                 1765                 1770             


Glu Ser  Val Arg Lys Val Thr  Glu His Leu Ser Gly  Cys Ile Gln 
    1775                 1780                 1785             


Gln Trp  Gly Asp Ser Val Leu  Gly Arg Arg Cys Arg  Asp Leu Leu 
    1790                 1795                 1800             


Leu Gln  Leu Tyr Leu Gln Arg  Pro Glu Leu Arg Val  Pro Val Pro 
    1805                 1810                 1815             


Glu Val  Leu Leu His Ser Glu  Gly Ala Ala Ser Ser  Ser Val Cys 
    1820                 1825                 1830             


Lys Leu  Asp Gly Leu Ile His  Arg Phe Ile Thr Leu  Leu Ala Asp 
    1835                 1840                 1845             


Thr Ser  Asp Ser Arg Ala Leu  Glu Asn Arg Gly Ala  Asp Ala Ser 
    1850                 1855                 1860             


Met Ala  Cys Arg Lys Leu Ala  Val Ala His Pro Leu  Leu Leu Leu 
    1865                 1870                 1875             


Arg His  Leu Pro Met Ile Ala  Ala Leu Leu His Gly  Arg Thr His 
    1880                 1885                 1890             


Leu Asn  Phe Gln Glu Phe Arg  Gln Gln Asn His Leu  Ser Cys Phe 
    1895                 1900                 1905             


Leu His  Val Leu Gly Leu Leu  Glu Leu Leu Gln Pro  His Val Phe 
    1910                 1915                 1920             


Arg Ser  Glu His Gln Gly Ala  Leu Trp Asp Cys Leu  Leu Ser Phe 
    1925                 1930                 1935             


Ile Arg  Leu Leu Leu Asn Tyr  Arg Lys Ser Ser Arg  His Leu Ala 
    1940                 1945                 1950             


Ala Phe  Ile Asn Lys Phe Val  Gln Phe Ile His Lys  Tyr Ile Thr 
    1955                 1960                 1965             


Tyr Asn  Ala Pro Ala Ala Ile  Ser Phe Leu Gln Lys  His Ala Asp 
    1970                 1975                 1980             


Pro Leu  His Asp Leu Ser Phe  Asp Asn Ser Asp Leu  Val Met Leu 
    1985                 1990                 1995             


Lys Ser  Leu Leu Ala Gly Leu  Ser Leu Pro Ser Arg  Asp Asp Arg 
    2000                 2005                 2010             


Thr Asp  Arg Gly Leu Asp Glu  Glu Gly Glu Glu Glu  Ser Ser Ala 
    2015                 2020                 2025             


Gly Ser  Leu Pro Leu Val Ser  Val Ser Leu Phe Thr  Pro Leu Thr 
    2030                 2035                 2040             


Ala Ala  Glu Met Ala Pro Tyr  Met Lys Arg Leu Ser  Arg Gly Gln 
    2045                 2050                 2055             


Thr Val  Glu Asp Leu Leu Glu  Val Leu Ser Asp Ile  Asp Glu Met 
    2060                 2065                 2070             


Ser Arg  Arg Arg Pro Glu Ile  Leu Ser Phe Phe Ser  Thr Asn Leu 
    2075                 2080                 2085             


Gln Arg  Leu Met Ser Ser Ala  Glu Glu Cys Cys Arg  Asn Leu Ala 
    2090                 2095                 2100             


Phe Ser  Leu Ala Leu Arg Ser  Met Gln Asn Ser Pro  Ser Ile Ala 
    2105                 2110                 2115             


Ala Ala  Phe Leu Pro Thr Phe  Met Tyr Cys Leu Gly  Ser Gln Asp 
    2120                 2125                 2130             


Phe Glu  Val Val Gln Thr Ala  Leu Arg Asn Leu Pro  Glu Tyr Ala 
    2135                 2140                 2145             


Leu Leu  Cys Gln Glu His Ala  Ala Val Leu Leu His  Arg Ala Phe 
    2150                 2155                 2160             


Leu Val  Gly Met Tyr Gly Gln  Met Asp Pro Ser Ala  Gln Ile Ser 
    2165                 2170                 2175             


Glu Ala  Leu Arg Ile Leu His  Met Glu Ala Val Met  
    2180                 2185                 2190 


<210>  5535
<211>  1204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS2__Homo_sapiens__NP_065799

<400>  5535

Met Lys Asp Gln Gln Thr Val Ile Met Thr Glu Cys Thr Ser Leu Gln 
1               5                   10                  15      


Phe Val Ser Pro Phe Ala Phe Glu Ala Met Gln Lys Val Asp Val Val 
            20                  25                  30          


Cys Leu Ala Ser Leu Ser Asp Pro Glu Leu Arg Leu Leu Leu Pro Cys 
        35                  40                  45              


Leu Val Arg Met Ala Leu Cys Ala Pro Ala Asp Gln Ser Gln Ser Trp 
    50                  55                  60                  


Ala Gln Asp Lys Lys Leu Ile Leu Arg Leu Leu Ser Gly Val Glu Ala 
65                  70                  75                  80  


Val Asn Ser Ile Val Ala Leu Leu Ser Val Asp Phe His Ala Leu Glu 
                85                  90                  95      


Gln Asp Ala Ser Lys Glu Gln Gln Leu Arg His Lys Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Glu Ser Ile Leu Val Ser Gln Leu Gln His Gly Leu Thr Leu 
        115                 120                 125             


Glu Phe Glu His Ser Asp Ser Pro Arg Arg Leu Arg Leu Val Leu Ser 
    130                 135                 140                 


Glu Leu Leu Ala Ile Met Asn Lys Val Ser Glu Ser Asn Gly Glu Phe 
145                 150                 155                 160 


Phe Phe Lys Ser Ser Glu Leu Phe Glu Ser Pro Val Tyr Leu Glu Glu 
                165                 170                 175     


Ala Ala Asp Val Leu Cys Ile Leu Gln Ala Glu Leu Pro Ser Leu Leu 
            180                 185                 190         


Pro Ile Val Asp Val Ala Glu Ala Leu Leu His Val Arg Asn Gly Ala 
        195                 200                 205             


Trp Phe Leu Cys Leu Leu Val Ala Asn Val Pro Asp Ser Phe Asn Glu 
    210                 215                 220                 


Val Cys Arg Gly Leu Ile Lys Asn Gly Glu Arg Gln Asp Glu Glu Ser 
225                 230                 235                 240 


Leu Gly Gly Arg Arg Arg Thr Asp Ala Leu Arg Phe Leu Cys Lys Met 
                245                 250                 255     


Asn Pro Ser Gln Ala Leu Lys Val Arg Gly Met Val Val Glu Glu Cys 
            260                 265                 270         


His Leu Pro Gly Leu Gly Val Ala Leu Thr Leu Asp His Thr Lys Asn 
        275                 280                 285             


Glu Ala Cys Glu Asp Gly Val Ser Asp Leu Val Cys Phe Val Ser Gly 
    290                 295                 300                 


Leu Leu Leu Gly Thr Asn Ala Lys Val Arg Thr Trp Phe Gly Thr Phe 
305                 310                 315                 320 


Ile Arg Asn Gly Gln Gln Arg Lys Arg Glu Thr Ser Ser Ser Val Leu 
                325                 330                 335     


Trp Gln Met Arg Arg Gln Leu Leu Leu Glu Leu Met Gly Ile Leu Pro 
            340                 345                 350         


Thr Val Arg Ser Thr Arg Ile Val Glu Glu Ala Asp Val Asp Met Glu 
        355                 360                 365             


Pro Asn Val Ser Val Tyr Ser Gly Leu Lys Glu Glu His Val Val Lys 
    370                 375                 380                 


Ala Ser Ala Leu Leu Arg Leu Tyr Cys Ala Leu Met Gly Ile Ala Gly 
385                 390                 395                 400 


Leu Lys Pro Thr Glu Glu Glu Ala Glu Gln Leu Leu Gln Leu Met Thr 
                405                 410                 415     


Ser Arg Pro Pro Ala Thr Pro Ala Gly Val Arg Phe Val Ser Leu Ser 
            420                 425                 430         


Phe Cys Met Leu Leu Ala Phe Ser Thr Leu Val Ser Thr Pro Glu Gln 
        435                 440                 445             


Glu Gln Leu Met Val Val Trp Leu Ser Trp Met Ile Lys Glu Glu Ala 
    450                 455                 460                 


Tyr Phe Glu Ser Thr Ser Gly Val Ser Ala Ser Phe Gly Glu Met Leu 
465                 470                 475                 480 


Leu Leu Val Ala Met Tyr Phe His Ser Asn Gln Leu Ser Ala Ile Ile 
                485                 490                 495     


Asp Leu Val Cys Ser Thr Leu Gly Met Lys Ile Val Ile Lys Pro Ser 
            500                 505                 510         


Ser Leu Ser Arg Met Lys Thr Ile Phe Thr Gln Glu Ile Phe Thr Glu 
        515                 520                 525             


Gln Val Val Thr Ala His Ala Val Arg Val Pro Val Thr Ser Asn Leu 
    530                 535                 540                 


Ser Ala Asn Ile Thr Gly Phe Leu Pro Ile His Cys Ile Tyr Gln Leu 
545                 550                 555                 560 


Leu Arg Ser Arg Ser Phe Thr Lys His Lys Val Ser Ile Lys Asp Trp 
                565                 570                 575     


Ile Tyr Arg Gln Leu Cys Glu Thr Ser Thr Pro Leu His Pro Gln Leu 
            580                 585                 590         


Leu Pro Leu Ile Asp Val Tyr Ile Asn Ser Ile Leu Thr Pro Ala Ser 
        595                 600                 605             


Lys Ser Asn Pro Glu Ala Thr Asn Gln Pro Val Thr Glu Gln Glu Ile 
    610                 615                 620                 


Leu Asn Ile Phe Gln Gly Val Ile Gly Gly Asp Asn Ile Arg Leu Asn 
625                 630                 635                 640 


Gln Arg Phe Ser Ile Thr Ala Gln Leu Leu Val Leu Tyr Tyr Ile Leu 
                645                 650                 655     


Ser Tyr Glu Glu Ala Leu Leu Ala Asn Thr Lys Thr Leu Ala Ala Met 
            660                 665                 670         


Gln Arg Lys Pro Lys Ser Tyr Ser Ser Ser Leu Met Asp Gln Ile Pro 
        675                 680                 685             


Ile Lys Phe Leu Ile Arg Gln Ala Gln Gly Leu Gln Gln Glu Leu Gly 
    690                 695                 700                 


Gly Leu His Ser Ala Leu Leu Arg Leu Leu Ala Thr Asn Tyr Pro His 
705                 710                 715                 720 


Leu Cys Ile Val Asp Asp Trp Ile Cys Glu Glu Glu Ile Thr Gly Thr 
                725                 730                 735     


Asp Ala Leu Leu Arg Arg Met Leu Leu Thr Asn Asn Ala Lys Asn His 
            740                 745                 750         


Ser Pro Lys Gln Leu Gln Glu Ala Phe Ser Ala Val Pro Val Asn His 
        755                 760                 765             


Thr Gln Val Met Gln Ile Ile Glu His Leu Thr Leu Leu Ser Ala Ser 
    770                 775                 780                 


Glu Leu Ile Pro Tyr Ala Glu Val Leu Thr Ser Asn Met Ser Gln Leu 
785                 790                 795                 800 


Leu Asn Ser Gly Val Pro Arg Arg Ile Leu Gln Thr Val Asn Lys Leu 
                805                 810                 815     


Trp Met Val Leu Asn Thr Val Met Pro Arg Arg Leu Trp Val Met Thr 
            820                 825                 830         


Val Asn Ala Leu Gln Pro Ser Ile Lys Phe Val Arg Gln Gln Lys Tyr 
        835                 840                 845             


Thr Gln Asn Asp Leu Met Ile Asp Pro Leu Ile Val Leu Arg Cys Asp 
    850                 855                 860                 


Gln Arg Val His Arg Cys Pro Pro Leu Met Asp Ile Thr Leu His Met 
865                 870                 875                 880 


Leu Asn Gly Tyr Leu Leu Ala Ser Lys Ala Tyr Leu Ser Ala His Leu 
                885                 890                 895     


Lys Glu Thr Glu Gln Asp Arg Pro Ser Gln Asn Asn Thr Ile Gly Leu 
            900                 905                 910         


Val Gly Gln Thr Asp Ala Pro Glu Val Thr Arg Glu Glu Leu Lys Asn 
        915                 920                 925             


Ala Leu Leu Ala Ala Gln Asp Ser Ala Ala Val Gln Ile Leu Leu Glu 
    930                 935                 940                 


Ile Cys Leu Pro Thr Glu Glu Glu Lys Ala Asn Gly Val Asn Pro Asp 
945                 950                 955                 960 


Ser Leu Leu Arg Asn Val Gln Ser Val Ile Thr Thr Ser Ala Pro Asn 
                965                 970                 975     


Lys Gly Met Glu Glu Gly Glu Asp Asn Leu Leu Cys Asn Leu Arg Glu 
            980                 985                 990         


Val Gln Cys Leu Ile Cys Cys Leu  Leu His Gln Met Tyr  Ile Ala Asp 
        995                 1000                 1005             


Pro Asn  Ile Ala Lys Leu Val  His Phe Gln Gly Tyr  Pro Cys Glu 
    1010                 1015                 1020             


Leu Leu  Pro Leu Thr Val Ala  Gly Ile Pro Ser Met  His Ile Cys 
    1025                 1030                 1035             


Leu Asp  Phe Ile Pro Glu Leu  Ile Ala Gln Pro Glu  Leu Glu Lys 
    1040                 1045                 1050             


Gln Ile  Phe Ala Ile Gln Leu  Leu Ser His Leu Cys  Ile Gln Tyr 
    1055                 1060                 1065             


Ala Leu  Pro Lys Ser Leu Ser  Val Ala Arg Leu Ala  Val Asn Val 
    1070                 1075                 1080             


Met Gly  Thr Leu Leu Thr Val  Leu Thr Gln Ala Lys  Arg Tyr Ala 
    1085                 1090                 1095             


Phe Phe  Met Pro Thr Leu Pro  Ser Leu Val Ser Phe  Cys Arg Ala 
    1100                 1105                 1110             


Phe Pro  Pro Leu Tyr Glu Asp  Ile Met Ser Leu Leu  Ile Gln Ile 
    1115                 1120                 1125             


Gly Gln  Val Cys Ala Ser Asp  Val Ala Thr Gln Thr  Arg Asp Ile 
    1130                 1135                 1140             


Asp Pro  Ile Ile Thr Arg Leu  Gln Gln Ile Lys Glu  Lys Pro Ser 
    1145                 1150                 1155             


Gly Trp  Ser Gln Ile Cys Lys  Asp Ser Ser Tyr Lys  Asn Gly Ser 
    1160                 1165                 1170             


Arg Asp  Thr Gly Ser Met Asp  Pro Asp Val Gln Leu  Cys His Cys 
    1175                 1180                 1185             


Ile Glu  Arg Thr Val Ile Glu  Ile Ile Asn Met Ser  Val Ser Gly 
    1190                 1195                 1200             


Ile 
    


<210>  5536
<211>  1042
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS3__Homo_sapiens__NP_075391

<400>  5536

Met Glu Leu Gln Lys Gly Lys Gly Ala Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Ala Pro Gly 
            20                  25                  30          


Gly Gly Arg Leu Leu Leu Ser Thr Ser Leu Asp Ala Lys Asp Glu Leu 
        35                  40                  45              


Glu Glu Arg Leu Glu Arg Cys Met Ser Ile Val Thr Ser Met Thr Ala 
    50                  55                  60                  


Gly Val Ser Glu Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys 
65                  70                  75                  80  


Lys Gly Leu Pro Gln His Glu Glu Ile Cys Leu Gly Leu Phe Thr Leu 
                85                  90                  95      


Ile Leu Thr Glu Pro Ala Gln Ala Gln Lys Cys Tyr Arg Asp Leu Ala 
            100                 105                 110         


Leu Val Ser Arg Asp Gly Met Asn Ile Val Leu Asn Lys Ile Asn Gln 
        115                 120                 125             


Ile Leu Met Glu Lys Tyr Leu Lys Leu Gln Asp Thr Cys Arg Thr Gln 
    130                 135                 140                 


Leu Val Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala 
145                 150                 155                 160 


Asp Gly Val Cys Met Thr Phe Met Lys Gln Ile Ala Gly Gly Asp Val 
                165                 170                 175     


Thr Ala Lys Asn Ile Trp Leu Ala Glu Ser Val Leu Asp Ile Leu Thr 
            180                 185                 190         


Glu Gln Arg Glu Trp Val Leu Lys Ser Ser Ile Leu Ile Ala Met Ala 
        195                 200                 205             


Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
    210                 215                 220                 


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu 
225                 230                 235                 240 


Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg 
                245                 250                 255     


Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys 
            260                 265                 270         


Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile 
        275                 280                 285             


Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg 
    290                 295                 300                 


Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val 
305                 310                 315                 320 


Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr 
                325                 330                 335     


Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr 
            340                 345                 350         


Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile 
        355                 360                 365             


Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser 
    370                 375                 380                 


Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu 
385                 390                 395                 400 


Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile 
                405                 410                 415     


Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr 
            420                 425                 430         


Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu 
        435                 440                 445             


Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val 
    450                 455                 460                 


Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro Lys 
465                 470                 475                 480 


Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe 
                485                 490                 495     


Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val 
            500                 505                 510         


Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr 
        515                 520                 525             


Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser 
    530                 535                 540                 


Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val 
545                 550                 555                 560 


Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu 
                565                 570                 575     


Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu 
            580                 585                 590         


Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu 
        595                 600                 605             


Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu 
    610                 615                 620                 


Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr 
625                 630                 635                 640 


Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe 
                645                 650                 655     


Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu 
            660                 665                 670         


Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr 
        675                 680                 685             


His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met 
    690                 695                 700                 


Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His 
705                 710                 715                 720 


Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg 
                725                 730                 735     


Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu 
            740                 745                 750         


Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp 
        755                 760                 765             


Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn Leu 
    770                 775                 780                 


Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu 
785                 790                 795                 800 


Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala 
                805                 810                 815     


His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys 
            820                 825                 830         


Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg 
        835                 840                 845             


Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg Pro 
    850                 855                 860                 


Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys 
865                 870                 875                 880 


Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile 
                885                 890                 895     


Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser 
            900                 905                 910         


Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp 
        915                 920                 925             


Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln 
    930                 935                 940                 


Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu 
945                 950                 955                 960 


Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr 
                965                 970                 975     


Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu 
            980                 985                 990         


Ser Ser Pro Arg Ser Arg Lys Asn  Ala Thr Gln Pro Pro  Asn Ala Glu 
        995                 1000                 1005             


Glu Glu  Ser Gly Ser Ser Ser  Ala Ser Glu Glu Glu  Asp Thr Lys 
    1010                 1015                 1020             


Pro Lys  Pro Thr Lys Arg Lys  Arg Lys Gly Ser Ser  Ala Val Gly 
    1025                 1030                 1035             


Ser Asp  Ser Asp 
    1040         


<210>  5537
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS4__Homo_sapiens__NP_291025

<400>  5537

Met Ala Ala His Leu Lys Lys Arg Val Tyr Glu Glu Phe Thr Lys Val 
1               5                   10                  15      


Val Gln Pro Gln Glu Glu Ile Ala Thr Lys Lys Leu Arg Leu Thr Lys 
            20                  25                  30          


Pro Ser Lys Ser Ala Ala Leu His Ile Asp Leu Cys Lys Ala Thr Ser 
        35                  40                  45              


Pro Ala Asp Ala Leu Gln Tyr Leu Leu Gln Phe Ala Arg Lys Pro Val 
    50                  55                  60                  


Glu Ala Glu Ser Val Glu Gly Val Val Arg Ile Leu Leu Glu His Tyr 
65                  70                  75                  80  


Tyr Lys Glu Asn Asp Pro Ser Val Arg Leu Lys Ile Ala Ser Leu Leu 
                85                  90                  95      


Gly Leu Leu Ser Lys Thr Ala Gly Phe Ser Pro Asp Cys Ile Met Asp 
            100                 105                 110         


Asp Ala Ile Asn Ile Leu Gln Asn Glu Lys Ser His Gln Val Leu Ala 
        115                 120                 125             


Gln Leu Leu Asp Thr Leu Leu Ala Ile Gly Thr Lys Leu Pro Glu Asn 
    130                 135                 140                 


Gln Ala Ile Gln Met Arg Leu Val Asp Val Ala Cys Lys His Leu Thr 
145                 150                 155                 160 


Asp Thr Ser His Gly Val Arg Asn Lys Cys Leu Gln Leu Leu Gly Asn 
                165                 170                 175     


Leu Gly Ser Leu Glu Lys Ser Val Thr Lys Asp Ala Glu Gly Leu Ala 
            180                 185                 190         


Ala Arg Asp Val Gln Lys Ile Ile Gly Asp Tyr Phe Ser Asp Gln Asp 
        195                 200                 205             


Pro Arg Val Arg Thr Ala Ala Ile Lys Ala Met Leu Gln Leu His Glu 
    210                 215                 220                 


Arg Gly Leu Lys Leu His Gln Thr Ile Tyr Asn Gln Ala Cys Lys Leu 
225                 230                 235                 240 


Leu Ser Asp Asp Tyr Glu Gln Val Arg Ser Ala Ala Val Gln Leu Ile 
                245                 250                 255     


Trp Val Val Ser Gln Leu Tyr Pro Glu Ser Ile Val Pro Ile Pro Ser 
            260                 265                 270         


Ser Asn Glu Glu Ile Arg Leu Val Asp Asp Ala Phe Gly Lys Ile Cys 
        275                 280                 285             


His Met Val Ser Asp Gly Ser Trp Val Val Arg Val Gln Ala Ala Lys 
    290                 295                 300                 


Leu Leu Gly Ser Met Glu Gln Val Ser Ser His Phe Leu Glu Gln Thr 
305                 310                 315                 320 


Leu Asp Lys Lys Leu Met Ser Asp Leu Arg Arg Lys Arg Thr Ala His 
                325                 330                 335     


Glu Arg Ala Lys Glu Leu Tyr Ser Ser Gly Glu Phe Ser Ser Gly Arg 
            340                 345                 350         


Lys Trp Gly Asp Asp Ala Pro Lys Glu Glu Val Asp Thr Gly Ala Val 
        355                 360                 365             


Asn Leu Ile Glu Ser Gly Ala Cys Gly Ala Phe Val His Gly Leu Glu 
    370                 375                 380                 


Asp Glu Met Tyr Glu Val Arg Ile Ala Ala Val Glu Ala Leu Cys Met 
385                 390                 395                 400 


Leu Ala Gln Ser Ser Pro Ser Phe Ala Glu Lys Cys Leu Asp Phe Leu 
                405                 410                 415     


Val Asp Met Phe Asn Asp Glu Ile Glu Glu Val Arg Leu Gln Ser Ile 
            420                 425                 430         


His Thr Met Arg Lys Ile Ser Asn Asn Ile Thr Leu Arg Glu Asp Gln 
        435                 440                 445             


Leu Asp Thr Val Leu Ala Val Leu Glu Asp Ser Ser Arg Asp Ile Arg 
    450                 455                 460                 


Glu Ala Leu His Glu Leu Leu Cys Cys Thr Asn Val Ser Thr Lys Glu 
465                 470                 475                 480 


Gly Ile His Leu Ala Leu Val Glu Leu Leu Lys Asn Leu Thr Lys Tyr 
                485                 490                 495     


Pro Thr Asp Arg Asp Ser Ile Trp Lys Cys Leu Lys Phe Leu Gly Ser 
            500                 505                 510         


Arg His Pro Thr Leu Val Leu Pro Leu Val Pro Glu Leu Leu Ser Thr 
        515                 520                 525             


His Pro Phe Phe Asp Thr Ala Glu Pro Asp Met Asp Asp Pro Ala Tyr 
    530                 535                 540                 


Ile Ala Val Leu Val Leu Ile Phe Asn Ala Ala Lys Thr Cys Pro Thr 
545                 550                 555                 560 


Met Pro Ala Leu Phe Ser Asp His Thr Phe Arg His Tyr Ala Tyr Leu 
                565                 570                 575     


Arg Asp Ser Leu Ser His Leu Val Pro Ala Leu Arg Leu Pro Gly Arg 
            580                 585                 590         


Lys Leu Val Ser Ser Ala Val Ser Pro Ser Ile Ile Pro Gln Glu Asp 
        595                 600                 605             


Pro Ser Gln Gln Phe Leu Gln Gln Ser Leu Glu Arg Val Tyr Ser Leu 
    610                 615                 620                 


Gln His Leu Asp Pro Gln Gly Ala Gln Glu Leu Leu Glu Phe Thr Ile 
625                 630                 635                 640 


Arg Asp Leu Gln Arg Leu Gly Glu Leu Gln Ser Glu Leu Ala Gly Val 
                645                 650                 655     


Ala Asp Phe Ser Ala Thr Tyr Leu Arg Cys Gln Leu Leu Leu Ile Lys 
            660                 665                 670         


Ala Leu Gln Glu Lys Leu Trp Asn Val Ala Ala Pro Leu Tyr Leu Lys 
        675                 680                 685             


Gln Ser Asp Leu Ala Ser Ala Ala Ala Lys Gln Ile Met Glu Glu Thr 
    690                 695                 700                 


Tyr Lys Met Glu Phe Met Tyr Ser Gly Val Glu Asn Lys Gln Val Val 
705                 710                 715                 720 


Ile Ile His His Met Arg Leu Gln Ala Lys Ala Leu Gln Leu Ile Val 
                725                 730                 735     


Thr Ala Arg Thr Thr Arg Gly Leu Asp Pro Leu Phe Gly Met Cys Glu 
            740                 745                 750         


Lys Phe Leu Gln Glu Val Asp Phe Phe Gln Arg Tyr Phe Ile Ala Asp 
        755                 760                 765             


Leu Pro His Leu Gln Asp Ser Phe Val Asp Lys Leu Leu Asp Leu Met 
    770                 775                 780                 


Pro Arg Leu Met Thr Ser Lys Pro Ala Glu Val Val Lys Ile Leu Gln 
785                 790                 795                 800 


Thr Met Leu Arg Gln Ser Ala Phe Leu His Leu Pro Leu Pro Glu Gln 
                805                 810                 815     


Ile His Lys Ala Ser Ala Thr Ile Ile Glu Pro Ala Gly Glu Ser Asp 
            820                 825                 830         


Asn Pro Leu Arg Phe Thr Ser Gly Leu Val Val Ala Leu Asp Val Asp 
        835                 840                 845             


Ala Thr Leu Glu His Val Gln Asp Pro Gln Asn Thr Val Lys Val Gln 
    850                 855                 860                 


Val Leu Tyr Pro Asp Gly Gln Ala Gln Met Ile His Pro Lys Pro Ala 
865                 870                 875                 880 


Asp Phe Arg Asn Pro Gly Pro Gly Arg His Arg Leu Ile Thr Gln Val 
                885                 890                 895     


Tyr Leu Ser His Thr Ala Trp Thr Glu Ala Cys Gln Val Glu Val Arg 
            900                 905                 910         


Leu Leu Leu Ala Tyr Asn Ser Ser Ala Arg Ile Pro Lys Cys Pro Trp 
        915                 920                 925             


Met Glu Gly Gly Glu Met Ser Pro Gln Val Glu Thr Ser Ile Glu Gly 
    930                 935                 940                 


Thr Ile Pro Phe Ser Lys Pro Val Lys Val Tyr Ile Met Pro Lys Pro 
945                 950                 955                 960 


Ala Arg Arg 
            


<210>  5538
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS5__Homo_sapiens__NP_085131

<400>  5538

Met Ser Ala Leu Cys Asp Pro Pro Gly Ala Pro Gly Pro Pro Gly Pro 
1               5                   10                  15      


Ala Pro Ala Thr His Gly Pro Ala Pro Leu Ser Ala Gln Glu Leu Ser 
            20                  25                  30          


Gln Glu Ile Lys Ala Phe Leu Thr Gly Val Asp Pro Ile Leu Gly His 
        35                  40                  45              


Gln Leu Ser Ala Arg Glu His Ala Arg Cys Gly Leu Leu Leu Leu Arg 
    50                  55                  60                  


Ser Leu Pro Pro Ala Arg Ala Ala Val Leu Asp His Leu Arg Gly Val 
65                  70                  75                  80  


Phe Asp Glu Ser Val Arg Ala His Leu Ala Ala Leu Asp Glu Thr Pro 
                85                  90                  95      


Val Ala Gly Pro Pro His Leu Arg Pro Pro Pro Pro Ser His Val Pro 
            100                 105                 110         


Ala Gly Gly Pro Gly Leu Glu Asp Val Val Gln Glu Val Gln Gln Val 
        115                 120                 125             


Leu Ser Glu Phe Ile Arg Ala Asn Pro Lys Ala Trp Ala Pro Val Ile 
    130                 135                 140                 


Ser Ala Trp Ser Ile Asp Leu Met Gly Gln Leu Ser Ser Thr Tyr Ser 
145                 150                 155                 160 


Gly Gln His Gln Arg Val Pro His Ala Thr Gly Ala Leu Asn Glu Leu 
                165                 170                 175     


Leu Gln Leu Trp Met Gly Cys Arg Ala Thr Arg Thr Leu Met Asp Ile 
            180                 185                 190         


Tyr Val Gln Cys Leu Ser Ala Leu Ile Gly Ser Cys Pro Asp Ala Cys 
        195                 200                 205             


Val Asp Ala Leu Leu Asp Thr Ser Val Gln His Ser Pro His Phe Asp 
    210                 215                 220                 


Trp Val Val Ala His Ile Gly Ser Ser Phe Pro Gly Thr Ile Ile Ser 
225                 230                 235                 240 


Arg Val Leu Ser Cys Gly Leu Lys Asp Phe Cys Val His Gly Gly Ala 
                245                 250                 255     


Gly Gly Gly Ala Gly Ser Ser Gly Gly Ser Ser Ser Gln Thr Pro Ser 
            260                 265                 270         


Thr Asp Pro Phe Pro Gly Ser Pro Ala Ile Pro Ala Glu Lys Arg Val 
        275                 280                 285             


Pro Lys Ile Ala Ser Val Val Gly Ile Leu Gly His Leu Ala Ser Arg 
    290                 295                 300                 


His Gly Asp Ser Ile Arg Arg Glu Leu Leu Arg Met Phe His Asp Ser 
305                 310                 315                 320 


Leu Ala Gly Gly Ser Gly Gly Arg Ser Gly Asp Pro Ser Leu Gln Ala 
                325                 330                 335     


Thr Val Pro Phe Leu Leu Gln Leu Ala Val Met Ser Pro Ala Leu Leu 
            340                 345                 350         


Gly Thr Val Ser Gly Glu Leu Val Asp Cys Leu Lys Pro Pro Ala Val 
        355                 360                 365             


Leu Ser Gln Leu Gln Gln His Leu Gln Gly Phe Pro Arg Glu Glu Leu 
    370                 375                 380                 


Asp Asn Met Leu Asn Leu Ala Val His Leu Val Ser Gln Ala Ser Gly 
385                 390                 395                 400 


Ala Gly Ala Tyr Arg Leu Leu Gln Phe Leu Val Asp Thr Ala Met Pro 
                405                 410                 415     


Ala Ser Val Ile Thr Thr Gln Gly Leu Ala Val Pro Asp Thr Val Arg 
            420                 425                 430         


Glu Ala Cys Asp Arg Leu Ile Gln Leu Leu Leu Leu His Leu Gln Lys 
        435                 440                 445             


Leu Val His His Arg Gly Gly Ser Pro Gly Glu Gly Val Leu Gly Pro 
    450                 455                 460                 


Pro Pro Pro Pro Arg Leu Val Pro Phe Leu Asp Ala Leu Lys Asn His 
465                 470                 475                 480 


Val Gly Glu Leu Cys Gly Glu Thr Leu Arg Leu Glu Arg Lys Arg Phe 
                485                 490                 495     


Leu Trp Gln His Gln Leu Leu Gly Leu Leu Ser Val Tyr Thr Arg Pro 
            500                 505                 510         


Ser Cys Gly Pro Glu Ala Leu Gly His Leu Leu Ser Arg Ala Arg Ser 
        515                 520                 525             


Pro Glu Glu Leu Ser Leu Ala Thr Gln Leu Tyr Ala Gly Leu Val Val 
    530                 535                 540                 


Ser Leu Ser Gly Leu Leu Pro Leu Ala Phe Arg Ser Cys Leu Ala Arg 
545                 550                 555                 560 


Val His Ala Gly Thr Leu Gln Pro Pro Phe Thr Ala Arg Phe Leu Arg 
                565                 570                 575     


Asn Leu Ala Leu Leu Val Gly Trp Glu Gln Gln Gly Gly Glu Gly Pro 
            580                 585                 590         


Ala Ala Leu Gly Ala His Phe Gly Glu Ser Ala Ser Ala His Leu Ser 
        595                 600                 605             


Asp Leu Ala Pro Leu Leu Leu His Pro Glu Glu Glu Val Ala Glu Ala 
    610                 615                 620                 


Ala Ala Ser Leu Leu Ala Ile Cys Pro Phe Pro Ser Glu Ala Leu Ser 
625                 630                 635                 640 


Pro Ser Gln Leu Leu Gly Leu Val Arg Ala Gly Val His Arg Phe Phe 
                645                 650                 655     


Ala Ser Leu Arg Leu His Gly Pro Pro Gly Val Ala Ser Ala Cys Gln 
            660                 665                 670         


Leu Leu Thr Arg Leu Ser Gln Thr Ser Pro Ala Gly Leu Lys Ala Val 
        675                 680                 685             


Leu Gln Leu Leu Val Glu Gly Ala Leu His Arg Gly Asn Thr Glu Leu 
    690                 695                 700                 


Phe Gly Gly Gln Val Asp Gly Asp Asn Glu Thr Leu Ser Val Val Ser 
705                 710                 715                 720 


Ala Ser Leu Ala Ser Ala Ser Leu Leu Asp Thr Asn Arg Arg His Thr 
                725                 730                 735     


Ala Ala Val Pro Gly Pro Gly Gly Ile Trp Ser Val Phe His Ala Gly 
            740                 745                 750         


Val Ile Gly Arg Gly Leu Lys Pro Pro Lys Phe Val Gln Ser Arg Asn 
        755                 760                 765             


Gln Gln Glu Val Ile Tyr Asn Thr Gln Ser Leu Leu Ser Leu Leu Val 
    770                 775                 780                 


His Cys Cys Ser Ala Pro Gly Gly Thr Glu Cys Gly Glu Cys Trp Gly 
785                 790                 795                 800 


Ala Pro Ile Leu Ser Pro Glu Ala Ala Lys Ala Val Ala Val Thr Leu 
                805                 810                 815     


Val Glu Ser Val Cys Pro Asp Ala Ala Gly Ala Glu Leu Ala Trp Pro 
            820                 825                 830         


Pro Glu Glu His Ala Arg Ala Thr Val Glu Arg Asp Leu Arg Ile Gly 
        835                 840                 845             


Arg Arg Phe Arg Glu Gln Pro Leu Leu Phe Glu Leu Leu Lys Leu Val 
    850                 855                 860                 


Ala Ala Ala Pro Pro Ala Leu Cys Tyr Cys Ser Val Leu Leu Arg Gly 
865                 870                 875                 880 


Leu Leu Ala Ala Leu Leu Gly His Trp Glu Ala Ser Arg His Pro Asp 
                885                 890                 895     


Thr Thr His Ser Pro Trp His Leu Glu Ala Ser Cys Thr Leu Val Ala 
            900                 905                 910         


Val Met Ala Glu Gly Ser Leu Leu Pro Pro Ala Leu Gly Asn Met His 
        915                 920                 925             


Glu Val Phe Ser Gln Leu Ala Pro Phe Glu Val Arg Leu Leu Leu Leu 
    930                 935                 940                 


Ser Val Trp Gly Phe Leu Arg Glu His Gly Pro Leu Pro Gln Lys Phe 
945                 950                 955                 960 


Ile Phe Gln Ser Glu Arg Gly Arg Phe Ile Arg Asp Phe Ser Arg Glu 
                965                 970                 975     


Gly Gly Gly Glu Gly Gly Pro His Leu Ala Val Leu His Ser Val Leu 
            980                 985                 990         


His Arg Asn Ile Asp Arg Leu Gly  Leu Phe Ser Gly Arg  Phe Gln Ala 
        995                 1000                 1005             


Pro Ser  Pro Ser Thr Leu Leu  Arg Gln Gly Thr 
    1010                 1015                 


<210>  5539
<211>  874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS6__Homo_sapiens__NP_001035026

<400>  5539

Met Asn Gln Arg Ser His Leu Gly Thr Thr Tyr Leu Asp Thr Ala Lys 
1               5                   10                  15      


Gly Ala Val Glu Thr Phe Met Lys Leu Arg Ala Arg Asp Pro Ala Ser 
            20                  25                  30          


Arg Gly Asp Arg Tyr Met Leu Val Thr Phe Glu Glu Pro Pro Tyr Ala 
        35                  40                  45              


Ile Lys Ala Gly Trp Lys Glu Asn His Ala Thr Phe Met Asn Glu Leu 
    50                  55                  60                  


Lys Asn Leu Gln Ala Glu Gly Leu Thr Thr Leu Gly Gln Ser Leu Arg 
65                  70                  75                  80  


Thr Ala Phe Asp Leu Leu Asn Leu Asn Arg Leu Val Thr Gly Ile Asp 
                85                  90                  95      


Asn Tyr Gly Gln Gly Arg Asn Pro Phe Phe Leu Glu Pro Ala Ile Ile 
            100                 105                 110         


Ile Thr Ile Thr Asp Gly Ser Lys Leu Thr Thr Thr Ser Gly Val Gln 
        115                 120                 125             


Asp Glu Leu His Leu Pro Leu Asn Ser Pro Leu Pro Gly Ser Glu Leu 
    130                 135                 140                 


Thr Lys Glu Pro Phe Arg Trp Asp Gln Arg Leu Phe Ala Leu Val Leu 
145                 150                 155                 160 


Arg Leu Pro Gly Thr Met Ser Val Glu Ser Glu Gln Leu Thr Gly Val 
                165                 170                 175     


Pro Leu Asp Asp Ser Ala Ile Thr Pro Met Cys Glu Val Thr Gly Gly 
            180                 185                 190         


Arg Ser Tyr Ser Val Cys Ser Pro Arg Met Leu Asn Gln Cys Leu Glu 
        195                 200                 205             


Ser Leu Val Gln Lys Val Gln Ser Gly Val Val Ile Asn Phe Glu Lys 
    210                 215                 220                 


Ala Gly Pro Asp Pro Ser Pro Val Glu Asp Gly Gln Pro Asp Ile Ser 
225                 230                 235                 240 


Arg Pro Phe Gly Ser Gln Pro Trp His Ser Cys His Lys Leu Ile Tyr 
                245                 250                 255     


Val Arg Pro Asn Pro Lys Thr Gly Val Pro Ile Gly His Trp Pro Val 
            260                 265                 270         


Pro Glu Ser Phe Trp Pro Asp Gln Asn Ser Pro Thr Leu Pro Pro Arg 
        275                 280                 285             


Thr Ser His Pro Val Val Lys Phe Ser Cys Thr Asp Cys Glu Pro Met 
    290                 295                 300                 


Val Ile Asp Lys Leu Pro Phe Asp Lys Tyr Glu Leu Glu Pro Ser Pro 
305                 310                 315                 320 


Leu Thr Gln Phe Ile Leu Glu Arg Lys Ser Pro Gln Thr Cys Trp Gln 
                325                 330                 335     


Val Tyr Val Ser Asn Ser Ala Lys Tyr Ser Glu Leu Gly His Pro Phe 
            340                 345                 350         


Gly Tyr Leu Lys Ala Ser Thr Ala Leu Asn Cys Val Asn Leu Phe Val 
        355                 360                 365             


Met Pro Tyr Asn Tyr Pro Val Leu Leu Pro Leu Leu Asp Asp Leu Phe 
    370                 375                 380                 


Lys Val His Lys Ala Lys Pro Thr Leu Lys Trp Arg Gln Ser Phe Glu 
385                 390                 395                 400 


Ser Tyr Leu Lys Thr Met Pro Pro Tyr Tyr Leu Gly Pro Leu Lys Lys 
                405                 410                 415     


Ala Val Arg Met Met Gly Ala Pro Asn Leu Ile Ala Asp Ser Met Glu 
            420                 425                 430         


Tyr Gly Leu Ser Tyr Ser Val Ile Ser Tyr Leu Lys Lys Leu Ser Gln 
        435                 440                 445             


Gln Ala Lys Ile Glu Ser Asp Arg Val Ile Gly Ser Val Gly Lys Lys 
    450                 455                 460                 


Val Val Gln Glu Thr Gly Ile Lys Val Arg Ser Arg Ser His Gly Leu 
465                 470                 475                 480 


Ser Met Ala Tyr Arg Lys Asp Phe Gln Gln Leu Leu Gln Gly Ile Ser 
                485                 490                 495     


Glu Asp Val Pro His Arg Leu Leu Asp Leu Asn Met Lys Glu Tyr Thr 
            500                 505                 510         


Gly Phe Gln Val Ala Leu Leu Asn Lys Asp Leu Lys Pro Gln Thr Phe 
        515                 520                 525             


Arg Asn Ala Tyr Asp Ile Pro Arg Arg Asn Leu Leu Asp His Leu Thr 
    530                 535                 540                 


Arg Met Arg Ser Asn Leu Leu Lys Ser Thr Arg Arg Phe Leu Lys Gly 
545                 550                 555                 560 


Gln Asp Glu Asp Gln Val His Ser Val Pro Ile Ala Gln Met Gly Asn 
                565                 570                 575     


Tyr Gln Glu Tyr Leu Lys Gln Val Pro Ser Pro Leu Arg Glu Leu Asp 
            580                 585                 590         


Pro Asp Gln Pro Arg Arg Leu His Thr Phe Gly Asn Pro Phe Lys Leu 
        595                 600                 605             


Asp Lys Lys Gly Met Met Ile Asp Glu Ala Asp Glu Phe Val Ala Gly 
    610                 615                 620                 


Pro Gln Asn Lys His Lys Arg Pro Gly Glu Pro Asn Met Gln Gly Ile 
625                 630                 635                 640 


Pro Lys Arg Arg Arg Cys Met Ser Pro Leu Leu Arg Gly Arg Gln Gln 
                645                 650                 655     


Asn Pro Val Val Asn Asn His Ile Gly Gly Lys Gly Pro Pro Ala Pro 
            660                 665                 670         


Thr Thr Gln Ala Gln Pro Asp Leu Ile Lys Pro Leu Pro Leu His Lys 
        675                 680                 685             


Ile Ser Glu Thr Thr Asn Asp Ser Ile Ile His Asp Val Val Glu Asn 
    690                 695                 700                 


His Val Ala Asp Gln Leu Ser Ser Asp Ile Thr Pro Asn Ala Met Asp 
705                 710                 715                 720 


Thr Glu Phe Ser Ala Ser Ser Pro Ala Ser Leu Leu Glu Arg Pro Thr 
                725                 730                 735     


Asn His Met Glu Ala Leu Gly His Asp His Leu Gly Thr Asn Asp Leu 
            740                 745                 750         


Thr Val Gly Gly Phe Leu Glu Asn His Glu Glu Pro Arg Asp Lys Glu 
        755                 760                 765             


Gln Cys Ala Glu Glu Asn Ile Pro Ala Ser Ser Leu Asn Lys Gly Lys 
    770                 775                 780                 


Lys Leu Met His Cys Arg Ser His Glu Glu Val Asn Thr Glu Leu Lys 
785                 790                 795                 800 


Ala Gln Ile Met Lys Glu Ile Arg Lys Pro Gly Arg Lys Tyr Glu Arg 
                805                 810                 815     


Ile Phe Thr Leu Leu Lys His Val Gln Gly Ser Leu Gln Thr Arg Leu 
            820                 825                 830         


Ile Phe Leu Gln Asn Val Ile Lys Glu Ala Ser Arg Phe Lys Lys Arg 
        835                 840                 845             


Met Leu Ile Glu Gln Leu Glu Asn Phe Leu Asp Glu Ile His Arg Arg 
    850                 855                 860                 


Ala Asn Gln Ile Asn His Ile Asn Ser Asn 
865                 870                 


<210>  5540
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS7__Homo_sapiens__NP_001186738

<400>  5540

Met Ala Ser Asn Ser Thr Lys Ser Phe Leu Ala Asp Ala Gly Tyr Gly 
1               5                   10                  15      


Glu Gln Glu Leu Asp Ala Asn Ser Ala Leu Met Glu Leu Asp Lys Gly 
            20                  25                  30          


Leu Arg Ser Gly Lys Leu Gly Glu Gln Cys Glu Ala Val Val Arg Phe 
        35                  40                  45              


Pro Arg Leu Phe Gln Lys Tyr Pro Phe Pro Ile Leu Ile Asn Ser Ala 
    50                  55                  60                  


Phe Leu Lys Leu Ala Asp Val Phe Arg Val Gly Met Leu Gly Ser Leu 
65                  70                  75                  80  


Ala Ser Ile Ile Pro Glu Arg Lys Asn Ala His His Ser Ile Arg Gln 
                85                  90                  95      


Ser Leu Asp Ser His Asp Asn Val Glu Val Glu Ala Ala Val Phe Ala 
            100                 105                 110         


Ala Ala Asn Phe Ser Ala Gln Ser Lys Asp Phe Ala Val Gly Ile Cys 
        115                 120                 125             


Asn Lys Ile Ser Glu Met Ile Gln Gly Leu Ala Thr Pro Val Asp Leu 
    130                 135                 140                 


Lys Leu Lys Leu Ile Pro Ile Leu Gln His Met His His Asp Ala Ile 
145                 150                 155                 160 


Leu Ala Ser Ser Ala Arg Gln Leu Leu Gln Gln Leu Val Thr Ser Tyr 
                165                 170                 175     


Pro Ser Thr Lys Met Val Ile Val Ser Leu His Thr Phe Thr Leu Leu 
            180                 185                 190         


Ala Ala Ser Ser Leu Val Asp Thr Pro Lys Gln Ile Gln Leu Leu Leu 
        195                 200                 205             


Gln Tyr Leu Lys Asn Asp Pro Arg Lys Ala Val Lys Arg Leu Ala Ile 
    210                 215                 220                 


Gln Asp Leu Lys Leu Leu Ala Asn Lys Thr Pro His Thr Trp Ser Arg 
225                 230                 235                 240 


Glu Asn Ile Gln Ala Leu Cys Glu Cys Ala Leu Gln Thr Pro Tyr Asp 
                245                 250                 255     


Ser Leu Lys Leu Gly Met Leu Ser Val Leu Ser Thr Leu Ser Gly Thr 
            260                 265                 270         


Ile Ala Ile Lys His Tyr Phe Ser Ile Val Pro Gly Asn Val Ser Ser 
        275                 280                 285             


Ser Pro Arg Ser Ser Asp Leu Val Lys Leu Ala Gln Glu Cys Cys Tyr 
    290                 295                 300                 


His Asn Asn Arg Gly Ile Ala Ala His Gly Val Arg Val Leu Thr Asn 
305                 310                 315                 320 


Ile Thr Val Ser Cys Gln Glu Lys Asp Leu Leu Ala Leu Glu Gln Asp 
                325                 330                 335     


Ala Val Phe Gly Leu Glu Ser Leu Leu Val Leu Cys Ser Gln Asp Asp 
            340                 345                 350         


Ser Pro Gly Ala Gln Ala Thr Leu Lys Ile Ala Leu Asn Cys Met Val 
        355                 360                 365             


Lys Leu Ala Lys Gly Arg Pro His Leu Ser Gln Ser Val Val Glu Thr 
    370                 375                 380                 


Leu Leu Thr Gln Leu His Ser Ala Gln Asp Ala Ala Arg Ile Leu Met 
385                 390                 395                 400 


Cys His Cys Leu Ala Ala Ile Ala Met Gln Leu Pro Val Leu Gly Asp 
                405                 410                 415     


Gly Met Leu Gly Asp Leu Met Glu Leu Tyr Lys Val Ile Gly Arg Ser 
            420                 425                 430         


Ala Thr Asp Lys Gln Gln Glu Leu Leu Val Ser Leu Ala Thr Val Ile 
        435                 440                 445             


Phe Val Ala Ser Gln Lys Ala Leu Ser Val Glu Ser Lys Ala Val Ile 
    450                 455                 460                 


Lys Gln Gln Leu Glu Ser Val Ser Asn Gly Trp Thr Val Tyr Arg Ile 
465                 470                 475                 480 


Ala Arg Gln Ala Ser Arg Met Gly Asn His Asp Met Ala Lys Glu Leu 
                485                 490                 495     


Tyr Gln Ser Leu Leu Thr Gln Val Ala Ser Glu His Phe Tyr Phe Trp 
            500                 505                 510         


Leu Asn Ser Leu Lys Glu Phe Ser His Ala Glu Gln Cys Leu Thr Gly 
        515                 520                 525             


Leu Gln Glu Glu Asn Tyr Ser Ser Ala Leu Ser Cys Ile Ala Glu Ser 
    530                 535                 540                 


Leu Lys Phe Tyr His Lys Gly Ile Ala Ser Leu Thr Ala Ala Ser Thr 
545                 550                 555                 560 


Pro Leu Asn Pro Leu Ser Phe Gln Cys Glu Phe Val Lys Leu Arg Ile 
                565                 570                 575     


Asp Leu Leu Gln Ala Phe Ser Gln Leu Ile Cys Thr Cys Asn Ser Leu 
            580                 585                 590         


Lys Thr Ser Pro Pro Pro Ala Ile Ala Thr Thr Ile Ala Met Thr Leu 
        595                 600                 605             


Gly Asn Asp Leu Gln Arg Cys Gly Arg Ile Ser Asn Gln Met Lys Gln 
    610                 615                 620                 


Ser Met Glu Glu Phe Arg Ser Leu Ala Ser Arg Tyr Gly Asp Leu Tyr 
625                 630                 635                 640 


Gln Ala Ser Phe Asp Ala Asp Ser Ala Thr Leu Arg Asn Val Glu Leu 
                645                 650                 655     


Gln Gln Gln Ser Cys Leu Leu Ile Ser His Ala Ile Glu Ala Leu Ile 
            660                 665                 670         


Leu Asp Pro Glu Ser Ala Ser Phe Gln Glu Tyr Gly Ser Thr Gly Thr 
        675                 680                 685             


Ala His Ala Asp Ser Glu Tyr Glu Arg Arg Met Met Ser Val Tyr Asn 
    690                 695                 700                 


His Val Leu Glu Glu Val Glu Ser Leu Asn Arg Lys Tyr Thr Pro Val 
705                 710                 715                 720 


Ser Tyr Met His Thr Ala Cys Leu Cys Asn Ala Ile Ile Ala Leu Leu 
                725                 730                 735     


Lys Val Pro Leu Ser Phe Gln Arg Tyr Phe Phe Gln Lys Leu Gln Ser 
            740                 745                 750         


Thr Ser Ile Lys Leu Ala Leu Ser Pro Ser Pro Arg Asn Pro Ala Glu 
        755                 760                 765             


Pro Ile Ala Val Gln Asn Asn Gln Gln Leu Ala Leu Lys Val Glu Gly 
    770                 775                 780                 


Val Val Gln His Gly Ser Lys Pro Gly Leu Phe Arg Lys Ile Gln Ser 
785                 790                 795                 800 


Val Cys Leu Asn Val Ser Ser Thr Leu Gln Ser Lys Ser Gly Gln Asp 
                805                 810                 815     


Tyr Lys Ile Pro Ile Asp Asn Met Thr Asn Glu Met Glu Gln Arg Val 
            820                 825                 830         


Glu Pro His Asn Asp Tyr Phe Ser Thr Gln Phe Leu Leu Asn Phe Ala 
        835                 840                 845             


Ile Leu Gly Thr His Asn Ile Thr Val Glu Ser Ser Val Lys Asp Ala 
    850                 855                 860                 


Asn Gly Ile Val Trp Lys Thr Gly Pro Arg Thr Thr Ile Phe Val Lys 
865                 870                 875                 880 


Ser Leu Glu Asp Pro Tyr Ser Gln Gln Ile Arg Leu Gln Gln Gln Gln 
                885                 890                 895     


Ala Gln Gln Pro Leu Gln Gln Gln Gln Gln Arg Asn Ala Tyr Thr Arg 
            900                 905                 910         


Phe 
    


<210>  5541
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTS8__Homo_sapiens__NP_060334

<400>  5541

Met Ser Ala Glu Ala Ala Asp Arg Glu Ala Ala Thr Ser Ser Arg Pro 
1               5                   10                  15      


Cys Thr Pro Pro Gln Thr Cys Trp Phe Glu Phe Leu Leu Glu Glu Ser 
            20                  25                  30          


Leu Leu Glu Lys His Leu Arg Lys Pro Cys Pro Asp Pro Ala Pro Val 
        35                  40                  45              


Gln Leu Ile Val Gln Phe Leu Glu Gln Ala Ser Lys Pro Ser Val Asn 
    50                  55                  60                  


Glu Gln Asn Gln Val Gln Pro Pro Pro Asp Asn Lys Arg Asn Arg Ile 
65                  70                  75                  80  


Leu Lys Leu Leu Ala Leu Lys Val Ala Ala His Leu Lys Trp Asp Leu 
                85                  90                  95      


Asp Ile Leu Glu Lys Ser Leu Ser Val Pro Val Leu Asn Met Leu Leu 
            100                 105                 110         


Asn Glu Leu Leu Cys Ile Ser Lys Val Pro Pro Gly Thr Lys His Val 
        115                 120                 125             


Asp Met Asp Leu Ala Thr Leu Pro Pro Thr Thr Ala Met Ala Val Leu 
    130                 135                 140                 


Leu Tyr Asn Arg Trp Ala Ile Arg Thr Ile Val Gln Ser Ser Phe Pro 
145                 150                 155                 160 


Val Lys Gln Ala Lys Pro Gly Pro Pro Gln Leu Ser Val Met Asn Gln 
                165                 170                 175     


Met Gln Gln Glu Lys Glu Leu Thr Glu Asn Ile Leu Lys Val Leu Lys 
            180                 185                 190         


Glu Gln Ala Ala Asp Ser Ile Leu Val Leu Glu Ala Ala Leu Lys Leu 
        195                 200                 205             


Asn Lys Asp Leu Tyr Val His Thr Met Arg Thr Leu Asp Leu Leu Ala 
    210                 215                 220                 


Met Glu Pro Gly Met Val Asn Gly Glu Thr Glu Ser Ser Thr Ala Gly 
225                 230                 235                 240 


Leu Lys Val Lys Thr Glu Glu Met Gln Cys Gln Val Cys Tyr Asp Leu 
                245                 250                 255     


Gly Ala Ala Tyr Phe Gln Gln Gly Ser Thr Asn Ser Ala Val Tyr Glu 
            260                 265                 270         


Asn Ala Arg Glu Lys Phe Phe Arg Thr Lys Glu Leu Ile Ala Glu Ile 
        275                 280                 285             


Gly Ser Leu Ser Leu His Cys Thr Ile Asp Glu Lys Arg Leu Ala Gly 
    290                 295                 300                 


Tyr Cys Gln Ala Cys Asp Val Leu Val Pro Ser Ser Asp Ser Thr Ser 
305                 310                 315                 320 


Gln Gln Leu Thr Pro Tyr Ser Gln Val His Ile Cys Leu Arg Ser Gly 
                325                 330                 335     


Asn Tyr Gln Glu Val Ile Gln Ile Phe Ile Glu Asp Asn Leu Thr Leu 
            340                 345                 350         


Ser Leu Pro Val Gln Phe Arg Gln Ser Val Leu Arg Glu Leu Phe Lys 
        355                 360                 365             


Lys Ala Gln Gln Gly Asn Glu Ala Leu Asp Glu Ile Cys Phe Lys Val 
    370                 375                 380                 


Cys Ala Cys Asn Thr Val Arg Asp Ile Leu Glu Gly Arg Thr Ile Ser 
385                 390                 395                 400 


Val Gln Phe Asn Gln Leu Phe Leu Arg Pro Asn Lys Glu Lys Ile Asp 
                405                 410                 415     


Phe Leu Leu Glu Val Cys Ser Arg Ser Val Asn Leu Glu Lys Ala Ser 
            420                 425                 430         


Glu Ser Leu Lys Gly Asn Met Ala Ala Phe Leu Lys Asn Val Cys Leu 
        435                 440                 445             


Gly Leu Glu Asp Leu Gln Tyr Val Phe Met Ile Ser Ser His Glu Leu 
    450                 455                 460                 


Phe Ile Thr Leu Leu Lys Asp Glu Glu Arg Lys Leu Leu Val Asp Gln 
465                 470                 475                 480 


Met Arg Lys Arg Ser Pro Arg Val Asn Leu Cys Ile Lys Pro Val Thr 
                485                 490                 495     


Ser Phe Tyr Asp Ile Pro Ala Ser Ala Ser Val Asn Ile Gly Gln Leu 
            500                 505                 510         


Glu His Gln Leu Ile Leu Ser Val Asp Pro Trp Arg Ile Arg Gln Ile 
        515                 520                 525             


Leu Ile Glu Leu His Gly Met Thr Ser Glu Arg Gln Phe Trp Thr Val 
    530                 535                 540                 


Ser Asn Lys Trp Glu Val Pro Ser Val Tyr Ser Gly Val Ile Leu Gly 
545                 550                 555                 560 


Ile Lys Asp Asn Leu Thr Arg Asp Leu Val Tyr Ile Leu Met Ala Lys 
                565                 570                 575     


Gly Leu His Cys Ser Thr Val Lys Asp Phe Ser His Ala Lys Gln Leu 
            580                 585                 590         


Phe Ala Ala Cys Leu Glu Leu Val Thr Glu Phe Ser Pro Lys Leu Arg 
        595                 600                 605             


Gln Val Met Leu Asn Glu Met Leu Leu Leu Asp Ile His Thr His Glu 
    610                 615                 620                 


Ala Gly Thr Gly Gln Ala Gly Glu Arg Pro Pro Ser Asp Leu Ile Ser 
625                 630                 635                 640 


Arg Val Arg Gly Tyr Leu Glu Met Arg Leu Pro Asp Ile Pro Leu Arg 
                645                 650                 655     


Gln Val Ile Ala Glu Glu Cys Val Ala Phe Met Leu Asn Trp Arg Glu 
            660                 665                 670         


Asn Glu Tyr Leu Thr Leu Gln Val Pro Ala Phe Leu Leu Gln Ser Asn 
        675                 680                 685             


Pro Tyr Val Lys Leu Gly Gln Leu Leu Ala Ala Thr Cys Lys Glu Leu 
    690                 695                 700                 


Pro Gly Pro Lys Glu Ser Arg Arg Thr Ala Lys Asp Leu Trp Glu Val 
705                 710                 715                 720 


Val Val Gln Ile Cys Ser Val Ser Ser Gln His Lys Arg Gly Asn Asp 
                725                 730                 735     


Gly Arg Val Ser Leu Ile Lys Gln Arg Glu Ser Thr Leu Gly Ile Met 
            740                 745                 750         


Tyr Arg Ser Glu Leu Leu Ser Phe Ile Lys Lys Leu Arg Glu Pro Leu 
        755                 760                 765             


Val Leu Thr Ile Ile Leu Ser Leu Phe Val Lys Leu His Asn Val Arg 
    770                 775                 780                 


Glu Asp Ile Val Asn Asp Ile Thr Ala Glu His Ile Ser Ile Trp Pro 
785                 790                 795                 800 


Ser Ser Ile Pro Asn Leu Gln Ser Val Asp Phe Glu Ala Val Ala Ile 
                805                 810                 815     


Thr Val Lys Glu Leu Val Arg Tyr Thr Leu Ser Ile Asn Pro Asn Asn 
            820                 825                 830         


His Ser Trp Leu Ile Ile Gln Ala Asp Ile Tyr Phe Ala Thr Asn Gln 
        835                 840                 845             


Tyr Ser Ala Ala Leu His Tyr Tyr Leu Gln Ala Gly Ala Val Cys Ser 
    850                 855                 860                 


Asp Phe Phe Asn Lys Ala Val Pro Pro Asp Val Tyr Thr Asp Gln Val 
865                 870                 875                 880 


Ile Lys Arg Met Ile Lys Cys Cys Ser Leu Leu Asn Cys His Thr Gln 
                885                 890                 895     


Val Ala Ile Leu Cys Gln Phe Leu Arg Glu Ile Asp Tyr Lys Thr Ala 
            900                 905                 910         


Phe Lys Ser Leu Gln Glu Gln Asn Ser His Asp Ala Met Asp Ser Tyr 
        915                 920                 925             


Tyr Asp Tyr Ile Trp Asp Val Thr Ile Leu Glu Tyr Leu Thr Tyr Leu 
    930                 935                 940                 


His His Lys Arg Gly Glu Thr Asp Lys Arg Gln Ile Ala Ile Lys Ala 
945                 950                 955                 960 


Ile Gly Gln Thr Glu Leu Asn Ala Ser Asn Pro Glu Glu Val Leu Gln 
                965                 970                 975     


Leu Ala Ala Gln Arg Arg Lys Lys Lys Phe Leu Gln Ala Met Ala Lys 
            980                 985                 990         


Leu Tyr Phe 
        995 


<210>  5542
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INTU__Homo_sapiens__NP_056508

<400>  5542

Met Ala Ser Val Ala Ser Cys Asp Ser Arg Pro Ser Ser Asp Glu Leu 
1               5                   10                  15      


Pro Gly Asp Pro Ser Ser Gln Glu Glu Asp Glu Asp Tyr Asp Phe Glu 
            20                  25                  30          


Asp Arg Val Ser Asp Ser Gly Ser Tyr Ser Ser Ala Ser Ser Asp Tyr 
        35                  40                  45              


Asp Asp Leu Glu Pro Glu Trp Leu Asp Ser Val Gln Lys Asn Gly Glu 
    50                  55                  60                  


Leu Phe Tyr Leu Glu Leu Ser Glu Asp Glu Glu Glu Ser Leu Leu Pro 
65                  70                  75                  80  


Glu Thr Pro Thr Val Asn His Val Arg Phe Ser Glu Asn Glu Ile Ile 
                85                  90                  95      


Ile Glu Asp Asp Tyr Lys Glu Arg Lys Lys Tyr Glu Pro Lys Leu Lys 
            100                 105                 110         


Gln Phe Thr Lys Ile Leu Arg Arg Lys Arg Leu Leu Pro Lys Arg Cys 
        115                 120                 125             


Asn Lys Lys Asn Ser Asn Asp Asn Gly Pro Val Ser Ile Leu Lys His 
    130                 135                 140                 


Gln Ser Asn Gln Lys Thr Gly Val Ile Val Gln Gln Arg Tyr Lys Asp 
145                 150                 155                 160 


Val Asn Val Tyr Val Asn Pro Lys Lys Leu Thr Val Ile Lys Ala Lys 
                165                 170                 175     


Glu Gln Leu Lys Leu Leu Glu Val Leu Val Gly Ile Ile His Gln Thr 
            180                 185                 190         


Lys Trp Ser Trp Arg Arg Thr Gly Lys Gln Gly Asp Gly Glu Arg Leu 
        195                 200                 205             


Val Val His Gly Leu Leu Pro Gly Gly Ser Ala Met Lys Ser Gly Gln 
    210                 215                 220                 


Val Leu Ile Gly Asp Val Leu Val Ala Val Asn Asp Val Asp Val Thr 
225                 230                 235                 240 


Thr Glu Asn Ile Glu Arg Val Leu Ser Cys Ile Pro Gly Pro Met Gln 
                245                 250                 255     


Val Lys Leu Thr Phe Glu Asn Ala Tyr Asp Val Lys Arg Glu Thr Ser 
            260                 265                 270         


His Pro Arg Gln Lys Lys Thr Gln Ser Asn Thr Ser Asp Leu Val Lys 
        275                 280                 285             


Leu Leu Trp Gly Glu Glu Val Glu Gly Ile Gln Gln Ser Gly Leu Asn 
    290                 295                 300                 


Thr Pro His Ile Ile Met Tyr Leu Thr Leu Gln Leu Asp Ser Glu Thr 
305                 310                 315                 320 


Ser Lys Glu Glu Gln Glu Ile Leu Tyr His Tyr Pro Met Ser Glu Ala 
                325                 330                 335     


Ser Gln Lys Leu Lys Ser Val Arg Gly Ile Phe Leu Thr Leu Cys Asp 
            340                 345                 350         


Met Leu Glu Asn Val Thr Gly Thr Gln Val Thr Ser Ser Ser Leu Leu 
        355                 360                 365             


Leu Asn Gly Lys Gln Ile His Val Ala Tyr Trp Lys Glu Ser Asp Lys 
    370                 375                 380                 


Leu Leu Leu Ile Gly Leu Pro Ala Glu Glu Val Pro Leu Pro Arg Leu 
385                 390                 395                 400 


Arg Asn Met Ile Glu Asn Val Ile Gln Thr Leu Lys Phe Met Tyr Gly 
                405                 410                 415     


Ser Leu Asp Ser Ala Phe Cys Gln Ile Glu Asn Val Pro Arg Leu Asp 
            420                 425                 430         


His Phe Phe Asn Leu Phe Phe Gln Arg Ala Leu Gln Pro Ala Lys Leu 
        435                 440                 445             


His Ser Ser Ala Ser Pro Ser Ala Gln Gln Tyr Asp Ala Ser Ser Ala 
    450                 455                 460                 


Val Leu Leu Asp Asn Leu Pro Gly Val Arg Trp Leu Thr Leu Pro Leu 
465                 470                 475                 480 


Glu Ile Lys Met Glu Leu Asp Met Ala Leu Ser Asp Leu Glu Ala Ala 
                485                 490                 495     


Asp Phe Ala Glu Leu Ser Glu Asp Tyr Tyr Asp Met Arg Arg Leu Tyr 
            500                 505                 510         


Thr Ile Leu Gly Ser Ser Leu Phe Tyr Lys Gly Tyr Leu Ile Cys Ser 
        515                 520                 525             


His Leu Pro Lys Asp Asp Leu Ile Asp Ile Ala Val Tyr Cys Arg His 
    530                 535                 540                 


Tyr Cys Leu Leu Pro Leu Ala Ala Lys Gln Arg Ile Gly Gln Leu Ile 
545                 550                 555                 560 


Ile Trp Arg Glu Val Phe Pro Gln His His Leu Arg Pro Leu Ala Asp 
                565                 570                 575     


Ser Ser Thr Glu Val Phe Pro Glu Pro Glu Gly Arg Tyr Phe Leu Leu 
            580                 585                 590         


Val Val Gly Leu Lys His Tyr Met Leu Cys Val Leu Leu Glu Ala Gly 
        595                 600                 605             


Gly Cys Ala Ser Lys Ala Ile Gly Ser Pro Gly Pro Asp Cys Val Tyr 
    610                 615                 620                 


Val Asp Gln Val Lys Thr Thr Leu His Gln Leu Asp Gly Val Asp Ser 
625                 630                 635                 640 


Arg Ile Asp Glu Arg Leu Ala Ser Ser Pro Val Pro Cys Leu Ser Cys 
                645                 650                 655     


Ala Asp Trp Phe Leu Thr Gly Ser Arg Glu Lys Thr Asp Ser Leu Thr 
            660                 665                 670         


Thr Ser Pro Ile Leu Ser Arg Leu Gln Gly Thr Ser Lys Val Ala Thr 
        675                 680                 685             


Ser Pro Thr Cys Arg Arg Thr Leu Phe Gly Asp Tyr Ser Leu Lys Thr 
    690                 695                 700                 


Arg Lys Pro Ser Pro Ser Cys Ser Ser Gly Gly Ser Asp Asn Gly Cys 
705                 710                 715                 720 


Glu Gly Gly Glu Asp Asp Gly Phe Ser Pro His Thr Thr Pro Asp Ala 
                725                 730                 735     


Val Arg Lys Gln Arg Glu Ser Gln Gly Ser Asp Gly Leu Glu Glu Ser 
            740                 745                 750         


Gly Thr Leu Leu Lys Val Thr Lys Lys Lys Ser Thr Leu Pro Asn Pro 
        755                 760                 765             


Phe His Leu Gly Asn Leu Lys Lys Asp Leu Pro Glu Lys Glu Leu Glu 
    770                 775                 780                 


Ile Tyr Asn Thr Val Lys Leu Thr Ser Gly Pro Glu Asn Thr Leu Phe 
785                 790                 795                 800 


His Tyr Val Ala Leu Glu Thr Val Gln Gly Ile Phe Ile Thr Pro Thr 
                805                 810                 815     


Leu Glu Glu Val Ala Gln Leu Ser Gly Ser Ile His Pro Gln Leu Ile 
            820                 825                 830         


Lys Asn Phe His Gln Cys Cys Leu Ser Ile Arg Ala Val Phe Gln Gln 
        835                 840                 845             


Thr Leu Val Glu Glu Lys Lys Lys Gly Leu Asn Ser Gly Asp His Ser 
    850                 855                 860                 


Asp Ser Ala Lys Ser Val Ser Ser Leu Asn Pro Val Lys Glu His Gly 
865                 870                 875                 880 


Val Leu Phe Glu Cys Ser Pro Gly Asn Trp Thr Asp Gln Lys Lys Ala 
                885                 890                 895     


Pro Pro Val Met Ala Tyr Trp Val Val Gly Arg Leu Phe Leu His Pro 
            900                 905                 910         


Lys Pro Gln Glu Leu Tyr Val Cys Phe His Asp Ser Val Thr Glu Ile 
        915                 920                 925             


Ala Ile Glu Ile Ala Phe Lys Leu Phe Phe Gly Leu Thr Leu 
    930                 935                 940         


<210>  5543
<211>  1065
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INVS__Homo_sapiens__NP_055240

<400>  5543

Met Asn Lys Ser Glu Asn Leu Leu Phe Ala Gly Ser Ser Leu Ala Ser 
1               5                   10                  15      


Gln Val His Ala Ala Ala Val Asn Gly Asp Lys Gly Ala Leu Gln Arg 
            20                  25                  30          


Leu Ile Val Gly Asn Ser Ala Leu Lys Asp Lys Glu Asp Gln Phe Gly 
        35                  40                  45              


Arg Thr Pro Leu Met Tyr Cys Val Leu Ala Asp Arg Leu Asp Cys Ala 
    50                  55                  60                  


Asp Ala Leu Leu Lys Ala Gly Ala Asp Val Asn Lys Thr Asp His Ser 
65                  70                  75                  80  


Gln Arg Thr Ala Leu His Leu Ala Ala Gln Lys Gly Asn Tyr Arg Phe 
                85                  90                  95      


Met Lys Leu Leu Leu Thr Arg Arg Ala Asn Trp Met Gln Lys Asp Leu 
            100                 105                 110         


Glu Glu Met Thr Pro Leu His Leu Thr Thr Arg His Arg Ser Pro Lys 
        115                 120                 125             


Cys Leu Ala Leu Leu Leu Lys Phe Met Ala Pro Gly Glu Val Asp Thr 
    130                 135                 140                 


Gln Asp Lys Asn Lys Gln Thr Ala Leu His Trp Ser Ala Tyr Tyr Asn 
145                 150                 155                 160 


Asn Pro Glu His Val Lys Leu Leu Ile Lys His Asp Ser Asn Ile Gly 
                165                 170                 175     


Ile Pro Asp Val Glu Gly Lys Ile Pro Leu His Trp Ala Ala Asn His 
            180                 185                 190         


Lys Asp Pro Ser Ala Val His Thr Val Arg Cys Ile Leu Asp Ala Ala 
        195                 200                 205             


Pro Thr Glu Ser Leu Leu Asn Trp Gln Asp Tyr Glu Gly Arg Thr Pro 
    210                 215                 220                 


Leu His Phe Ala Val Ala Asp Gly Asn Val Thr Val Val Asp Val Leu 
225                 230                 235                 240 


Thr Ser Tyr Glu Ser Cys Asn Ile Thr Ser Tyr Asp Asn Leu Phe Arg 
                245                 250                 255     


Thr Pro Leu His Trp Ala Ala Leu Leu Gly His Ala Gln Ile Val His 
            260                 265                 270         


Leu Leu Leu Glu Arg Asn Lys Ser Gly Thr Ile Pro Ser Asp Ser Gln 
        275                 280                 285             


Gly Ala Thr Pro Leu His Tyr Ala Ala Gln Ser Asn Phe Ala Glu Thr 
    290                 295                 300                 


Val Lys Val Phe Leu Lys His Pro Ser Val Lys Asp Asp Ser Asp Leu 
305                 310                 315                 320 


Glu Gly Arg Thr Ser Phe Met Trp Ala Ala Gly Lys Gly Ser Asp Asp 
                325                 330                 335     


Val Leu Arg Thr Met Leu Ser Leu Lys Ser Asp Ile Asp Ile Asn Met 
            340                 345                 350         


Ala Asp Lys Tyr Gly Gly Thr Ala Leu His Ala Ala Ala Leu Ser Gly 
        355                 360                 365             


His Val Ser Thr Val Lys Leu Leu Leu Glu Asn Asn Ala Gln Val Asp 
    370                 375                 380                 


Ala Thr Asp Val Met Lys His Thr Pro Leu Phe Arg Ala Cys Glu Met 
385                 390                 395                 400 


Gly His Lys Asp Val Ile Gln Thr Leu Ile Lys Gly Gly Ala Arg Val 
                405                 410                 415     


Asp Leu Val Asp Gln Asp Gly His Ser Leu Leu His Trp Ala Ala Leu 
            420                 425                 430         


Gly Gly Asn Ala Asp Val Cys Gln Ile Leu Ile Glu Asn Lys Ile Asn 
        435                 440                 445             


Pro Asn Val Gln Asp Tyr Ala Gly Arg Thr Pro Leu Gln Cys Ala Ala 
    450                 455                 460                 


Tyr Gly Gly Tyr Ile Asn Cys Met Ala Val Leu Met Glu Asn Asn Ala 
465                 470                 475                 480 


Asp Pro Asn Ile Gln Asp Lys Glu Gly Arg Thr Ala Leu His Trp Ser 
                485                 490                 495     


Cys Asn Asn Gly Tyr Leu Asp Ala Ile Lys Leu Leu Leu Asp Phe Ala 
            500                 505                 510         


Ala Phe Pro Asn Gln Met Glu Asn Asn Glu Glu Arg Tyr Thr Pro Leu 
        515                 520                 525             


Asp Tyr Ala Leu Leu Gly Glu Arg His Glu Val Ile Gln Phe Met Leu 
    530                 535                 540                 


Glu His Gly Ala Leu Ser Ile Ala Ala Ile Gln Asp Ile Ala Ala Phe 
545                 550                 555                 560 


Lys Ile Gln Ala Val Tyr Lys Gly Tyr Lys Val Arg Lys Ala Phe Arg 
                565                 570                 575     


Asp Arg Lys Asn Leu Leu Met Lys His Glu Gln Leu Arg Lys Asp Ala 
            580                 585                 590         


Ala Ala Lys Lys Arg Glu Glu Glu Asn Lys Arg Lys Glu Ala Glu Gln 
        595                 600                 605             


Gln Lys Gly Arg Arg Ser Pro Asp Ser Cys Arg Pro Gln Ala Leu Pro 
    610                 615                 620                 


Cys Leu Pro Ser Thr Gln Asp Val Pro Ser Arg Gln Ser Arg Ala Pro 
625                 630                 635                 640 


Ser Lys Gln Pro Pro Ala Gly Asn Val Ala Gln Gly Pro Glu Pro Arg 
                645                 650                 655     


Asp Ser Arg Gly Ser Pro Gly Gly Ser Leu Gly Gly Ala Leu Gln Lys 
            660                 665                 670         


Glu Gln His Val Ser Ser Asp Leu Gln Gly Thr Asn Ser Arg Arg Pro 
        675                 680                 685             


Asn Glu Thr Ala Arg Glu His Ser Lys Gly Gln Ser Ala Cys Val His 
    690                 695                 700                 


Phe Arg Pro Asn Glu Gly Ser Asp Gly Ser Arg His Pro Gly Val Pro 
705                 710                 715                 720 


Ser Val Glu Lys Ser Arg Gly Glu Thr Ala Gly Asp Glu Arg Cys Ala 
                725                 730                 735     


Lys Gly Lys Gly Phe Val Lys Gln Pro Ser Cys Ile Arg Val Ala Gly 
            740                 745                 750         


Pro Asp Glu Lys Gly Glu Asp Ser Arg Arg Ala Ala Ala Ser Leu Pro 
        755                 760                 765             


Pro His Asp Ser His Trp Lys Pro Ser Arg Arg His Asp Thr Glu Pro 
    770                 775                 780                 


Lys Ala Lys Cys Ala Pro Gln Lys Arg Arg Thr Gln Glu Leu Arg Gly 
785                 790                 795                 800 


Gly Arg Cys Ser Pro Ala Gly Ser Ser Arg Pro Gly Ser Ala Arg Gly 
                805                 810                 815     


Glu Ala Val His Ala Gly Gln Asn Pro Pro His His Arg Thr Pro Arg 
            820                 825                 830         


Asn Lys Val Thr Gln Ala Lys Leu Thr Gly Gly Leu Tyr Ser His Leu 
        835                 840                 845             


Pro Gln Ser Thr Glu Glu Leu Arg Ser Gly Ala Arg Arg Leu Glu Thr 
    850                 855                 860                 


Ser Thr Leu Ser Glu Asp Phe Gln Val Ser Lys Glu Thr Asp Pro Ala 
865                 870                 875                 880 


Pro Gly Pro Leu Ser Gly Gln Ser Val Asn Ile Asp Leu Leu Pro Val 
                885                 890                 895     


Glu Leu Arg Leu Gln Ile Ile Gln Arg Glu Arg Arg Arg Lys Glu Leu 
            900                 905                 910         


Phe Arg Lys Lys Asn Lys Ala Ala Ala Val Ile Gln Arg Ala Trp Arg 
        915                 920                 925             


Ser Tyr Gln Leu Arg Lys His Leu Ser His Leu Arg His Met Lys Gln 
    930                 935                 940                 


Leu Gly Ala Gly Asp Val Asp Arg Trp Arg Gln Glu Ser Thr Ala Leu 
945                 950                 955                 960 


Leu Leu Gln Val Trp Arg Lys Glu Leu Glu Leu Lys Phe Pro Gln Thr 
                965                 970                 975     


Thr Ala Val Ser Lys Ala Pro Lys Ser Pro Ser Lys Gly Thr Ser Gly 
            980                 985                 990         


Thr Lys Ser Thr Lys His Ser Val  Leu Lys Gln Ile Tyr  Gly Cys Ser 
        995                 1000                 1005             


His Glu  Gly Lys Ile His His  Pro Thr Arg Ser Val  Lys Ala Ser 
    1010                 1015                 1020             


Ser Val  Leu Arg Leu Asn Ser  Val Ser Asn Leu Gln  Cys Ile His 
    1025                 1030                 1035             


Leu Leu  Glu Asn Ser Gly Arg  Ser Lys Asn Phe Ser  Tyr Asn Leu 
    1040                 1045                 1050             


Gln Ser  Ala Thr Gln Pro Lys  Asn Lys Thr Lys Pro  
    1055                 1060                 1065 


<210>  5544
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IP6K1__Homo_sapiens__NP_001006115

<400>  5544

Met Leu Asp Gly Asn Ser Gly Leu Ser Ser Glu Lys Ile Ser His Asn 
1               5                   10                  15      


Pro Trp Ser Leu Arg Cys His Lys Gln Gln Leu Ser Arg Met Arg Ser 
            20                  25                  30          


Glu Ser Lys Asp Arg Lys Leu Tyr Lys Phe Leu Leu Leu Glu Asn Val 
        35                  40                  45              


Val His His Phe Lys Tyr Pro Cys Val Leu Asp Leu Lys Met Gly Thr 
    50                  55                  60                  


Arg Gln His Gly Asp Asp Ala Ser Ala Glu Lys Ala Ala Arg Gln Met 
65                  70                  75                  80  


Arg Lys Cys Glu Gln Ser Thr Ser Ala Thr Leu Gly Val Arg Val Cys 
                85                  90                  95      


Gly Met Gln Val Tyr Gln Leu Asp Thr Gly His Tyr Leu Cys Arg Asn 
            100                 105                 110         


Lys Tyr Tyr Gly Arg Gly Leu Ser Ile Glu Gly Phe Arg Asn Ala Leu 
        115                 120                 125             


Tyr Gln Tyr Leu His Asn Gly Leu Asp Leu Arg Arg Asp Leu Phe Glu 
    130                 135                 140                 


Pro Ile Leu Ser Lys Leu Arg Gly Leu Lys Ala Val Leu Glu Arg Gln 
145                 150                 155                 160 


Ala Ser Tyr Arg Phe Tyr Ser Ser Ser Leu Leu Val Ile Tyr Asp Gly 
                165                 170                 175     


Lys Glu Cys Arg Ala Glu Ser Cys Leu Asp Arg Arg Ser Glu Met Arg 
            180                 185                 190         


Leu Lys His Leu Asp Met Val Leu Pro Glu Val Ala Ser Ser Cys Gly 
        195                 200                 205             


Pro Ser Thr Ser Pro Ser Asn Thr Ser Pro Glu Ala Gly Pro Ser Ser 
    210                 215                 220                 


Gln Pro Lys Val Asp Val Arg Met Ile Asp Phe Ala His Ser Thr Phe 
225                 230                 235                 240 


Lys Gly Phe Arg Asp Asp Pro Thr Val His Asp Gly Pro Asp Arg Gly 
                245                 250                 255     


Tyr Val Phe Gly Leu Glu Asn Leu Ile Ser Ile Met Glu Gln Met Arg 
            260                 265                 270         


Asp Glu Asn Gln 
        275     


<210>  5545
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IP6K2__Homo_sapiens__NP_001005911

<400>  5545

Met Ser Pro Ala Phe Arg Ala Met Asp Val Glu Pro Arg Ala Lys Gly 
1               5                   10                  15      


Val Leu Leu Glu Pro Phe Val His Gln Val Gly Gly His Ser Cys Val 
            20                  25                  30          


Leu Arg Phe Asn Glu Thr Thr Leu Cys Lys Pro Leu Val Pro Arg Glu 
        35                  40                  45              


His Gln Phe Tyr Glu Thr Leu Pro Ala Glu Met Arg Lys Phe Thr Pro 
    50                  55                  60                  


Gln Tyr Lys Gly Gln Ser Gln Arg Pro Leu Val Ser Trp Pro Ser Leu 
65                  70                  75                  80  


Pro His Phe Phe Pro Trp Ser Phe Pro Leu Trp Pro Gln Gly Ser Val 
                85                  90                  95      


Ala 
    


<210>  5546
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IP6K3__Homo_sapiens__NP_001136355

<400>  5546

Met Val Val Gln Asn Ser Ala Asp Ala Gly Asp Met Arg Ala Gly Val 
1               5                   10                  15      


Gln Leu Glu Pro Phe Leu His Gln Val Gly Gly His Met Ser Val Met 
            20                  25                  30          


Lys Tyr Asp Glu His Thr Val Cys Lys Pro Leu Val Ser Arg Glu Gln 
        35                  40                  45              


Arg Phe Tyr Glu Ser Leu Pro Leu Ala Met Lys Arg Phe Thr Pro Gln 
    50                  55                  60                  


Tyr Lys Gly Thr Val Thr Val His Leu Trp Lys Asp Ser Thr Gly His 
65                  70                  75                  80  


Leu Ser Leu Val Ala Asn Pro Val Lys Glu Ser Gln Glu Pro Phe Lys 
                85                  90                  95      


Val Ser Thr Glu Ser Ala Ala Val Ala Ile Trp Gln Thr Leu Gln Gln 
            100                 105                 110         


Thr Thr Gly Ser Asn Gly Ser Asp Cys Thr Leu Ala Gln Trp Pro His 
        115                 120                 125             


Ala Gln Leu Ala Arg Ser Pro Lys Glu Ser Pro Ala Lys Ala Leu Leu 
    130                 135                 140                 


Arg Ser Glu Pro His Leu Asn Thr Pro Ala Phe Ser Leu Val Glu Asp 
145                 150                 155                 160 


Thr Asn Gly Asn Gln Val Glu Arg Lys Ser Phe Asn Pro Trp Gly Leu 
                165                 170                 175     


Gln Cys His Gln Ala His Leu Thr Arg Leu Cys Ser Glu Tyr Pro Glu 
            180                 185                 190         


Asn Lys Arg His Arg Phe Leu Leu Leu Glu Asn Val Val Ser Gln Tyr 
        195                 200                 205             


Thr His Pro Cys Val Leu Asp Leu Lys Met Gly Thr Arg Gln His Gly 
    210                 215                 220                 


Asp Asp Ala Ser Glu Glu Lys Lys Ala Arg His Met Arg Lys Cys Ala 
225                 230                 235                 240 


Gln Ser Thr Ser Ala Cys Leu Gly Val Arg Ile Cys Gly Met Gln Val 
                245                 250                 255     


Tyr Gln Thr Asp Lys Lys Tyr Phe Leu Cys Lys Asp Lys Tyr Tyr Gly 
            260                 265                 270         


Arg Lys Leu Ser Val Glu Gly Phe Arg Gln Ala Leu Tyr Gln Phe Leu 
        275                 280                 285             


His Asn Gly Ser His Leu Arg Arg Glu Leu Leu Glu Pro Ile Leu His 
    290                 295                 300                 


Gln Leu Arg Ala Leu Leu Ser Val Ile Arg Ser Gln Ser Ser Tyr Arg 
305                 310                 315                 320 


Phe Tyr Ser Ser Ser Leu Leu Val Ile Tyr Asp Gly Gln Glu Pro Pro 
                325                 330                 335     


Glu Arg Ala Pro Gly Ser Pro His Pro His Glu Ala Pro Gln Ala Ala 
            340                 345                 350         


His Gly Ser Ser Pro Gly Gly Leu Thr Lys Val Asp Ile Arg Met Ile 
        355                 360                 365             


Asp Phe Ala His Thr Thr Tyr Lys Gly Tyr Trp Asn Glu His Thr Thr 
    370                 375                 380                 


Tyr Asp Gly Pro Asp Pro Gly Tyr Ile Phe Gly Leu Glu Asn Leu Ile 
385                 390                 395                 400 


Arg Ile Leu Gln Asp Ile Gln Glu Gly Glu 
                405                 410 


<210>  5547
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPCEF1__Homo_sapiens__XP_005266979

<400>  5547

Met Thr Ser Tyr Met Ala Ile Asp Gly Ser Ala Leu Gln Val Pro Leu 
1               5                   10                  15      


Arg Gln Lys Pro Arg Arg Lys Thr Gln Gly Phe Leu Thr Met Ser Arg 
            20                  25                  30          


Arg Arg Ile Ser Cys Lys Asp Leu Gly His Ala Asp Cys Gln Gly Trp 
        35                  40                  45              


Leu Tyr Lys Lys Lys Glu Lys Gly Ser Phe Leu Ser Asn Lys Trp Lys 
    50                  55                  60                  


Lys Phe Trp Val Ile Leu Lys Gly Ser Ser Leu Tyr Trp Tyr Ser Asn 
65                  70                  75                  80  


Gln Met Ala Glu Lys Ala Asp Gly Phe Val Asn Leu Pro Asp Phe Thr 
                85                  90                  95      


Val Glu Arg Ala Ser Glu Cys Lys Lys Lys His Ala Phe Lys Ile Ser 
            100                 105                 110         


His Pro Gln Ile Lys Thr Phe Tyr Phe Ala Ala Glu Asn Val Gln Glu 
        115                 120                 125             


Met Asn Val Trp Leu Asn Lys Leu Gly Ser Ala Val Ile His Gln Glu 
    130                 135                 140                 


Ser Thr Thr Lys Asp Glu Glu Cys Tyr Ser Glu Ser Glu Gln Glu Asp 
145                 150                 155                 160 


Pro Glu Ile Ala Ala Glu Thr Pro Pro Pro Pro His Ala Ser Gln Thr 
                165                 170                 175     


Gln Ser Leu Thr Ala Gln Gln Ala Ser Ser Ser Ser Pro Ser Leu Ser 
            180                 185                 190         


Gly Thr Ser Tyr Ser Phe Ser Ser Leu Glu Asn Thr Val Lys Thr Pro 
        195                 200                 205             


Ser Ser Phe Pro Ser Ser Leu Ser Lys Glu Arg Gln Ser Leu Pro Asp 
    210                 215                 220                 


Thr Val Asn Ser Leu Ser Ala Ala Glu Asp Glu Gly Gln Pro Ile Thr 
225                 230                 235                 240 


Phe Ala Val Gln Val His Ser Pro Val Pro Ser Glu Ala Gly Ile His 
                245                 250                 255     


Lys Ala Leu Glu Asn Ser Phe Val Thr Ser Glu Ser Gly Phe Leu Asn 
            260                 265                 270         


Ser Leu Ser Ser Asp Asp Thr Ser Ser Leu Ser Ser Asn His Asp His 
        275                 280                 285             


Leu Thr Val Pro Asp Lys Pro Ala Gly Ser Lys Ile Met Asp Lys Glu 
    290                 295                 300                 


Glu Thr Lys Val Ser Glu Asp Asp Glu Met Glu Lys Leu Tyr Lys Ser 
305                 310                 315                 320 


Leu Glu Gln Ala Ser Leu Ser Pro Leu Gly Asp Arg Arg Pro Ser Thr 
                325                 330                 335     


Lys Lys Glu Leu Arg Lys Ser Phe Val Lys Arg Cys Lys Asn Pro Ser 
            340                 345                 350         


Ile Asn Glu Lys Leu His Lys Ile Arg Thr Leu Asn Ser Thr Leu Lys 
        355                 360                 365             


Cys Lys Glu His Asp Leu Ala Met Ile Asn Gln Leu Leu Asp Asp Pro 
    370                 375                 380                 


Lys Leu Thr Ala Arg Lys Tyr Arg Glu Trp Lys Val Met Asn Thr Leu 
385                 390                 395                 400 


Leu Ile Gln Asp Ile Tyr Gln Gln Gln Arg Ala Ser Pro Ala Pro Asp 
                405                 410                 415     


Asp Thr Asp Asp Thr Pro Gln Glu Leu Lys Lys Ser Pro Ser Ser Pro 
            420                 425                 430         


Ser Val Glu Asn Ser Ile 
        435             


<210>  5548
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPMK__Homo_sapiens__NP_689416

<400>  5548

Met Ala Thr Glu Pro Pro Ser Pro Leu Arg Val Glu Ala Pro Gly Pro 
1               5                   10                  15      


Pro Glu Met Arg Thr Ser Pro Ala Ile Glu Ser Thr Pro Glu Gly Thr 
            20                  25                  30          


Pro Gln Pro Ala Gly Gly Arg Leu Arg Phe Leu Asn Gly Cys Val Pro 
        35                  40                  45              


Leu Ser His Gln Val Ala Gly His Met Tyr Gly Lys Asp Lys Val Gly 
    50                  55                  60                  


Ile Leu Gln His Pro Asp Gly Thr Val Leu Lys Gln Leu Gln Pro Pro 
65                  70                  75                  80  


Pro Arg Gly Pro Arg Glu Leu Glu Phe Tyr Asn Met Val Tyr Ala Ala 
                85                  90                  95      


Asp Cys Phe Asp Gly Val Leu Leu Glu Leu Arg Lys Tyr Leu Pro Lys 
            100                 105                 110         


Tyr Tyr Gly Ile Trp Ser Pro Pro Thr Ala Pro Asn Asp Leu Tyr Leu 
        115                 120                 125             


Lys Leu Glu Asp Val Thr His Lys Phe Asn Lys Pro Cys Ile Met Asp 
    130                 135                 140                 


Val Lys Ile Gly Gln Lys Ser Tyr Asp Pro Phe Ala Ser Ser Glu Lys 
145                 150                 155                 160 


Ile Gln Gln Gln Val Ser Lys Tyr Pro Leu Met Glu Glu Ile Gly Phe 
                165                 170                 175     


Leu Val Leu Gly Met Arg Val Tyr His Val His Ser Asp Ser Tyr Glu 
            180                 185                 190         


Thr Glu Asn Gln His Tyr Gly Arg Ser Leu Thr Lys Glu Thr Ile Lys 
        195                 200                 205             


Asp Gly Val Ser Arg Phe Phe His Asn Gly Tyr Cys Leu Arg Lys Asp 
    210                 215                 220                 


Ala Val Ala Ala Ser Ile Gln Lys Ile Glu Lys Ile Leu Gln Trp Phe 
225                 230                 235                 240 


Glu Asn Gln Lys Gln Leu Asn Phe Tyr Ala Ser Ser Leu Leu Phe Val 
                245                 250                 255     


Tyr Glu Gly Ser Ser Gln Pro Thr Thr Thr Lys Leu Asn Asp Arg Thr 
            260                 265                 270         


Leu Ala Glu Lys Phe Leu Ser Lys Gly Gln Leu Ser Asp Thr Glu Val 
        275                 280                 285             


Leu Glu Tyr Asn Asn Asn Phe His Val Leu Ser Ser Thr Ala Asn Gly 
    290                 295                 300                 


Lys Ile Glu Ser Ser Val Gly Lys Ser Leu Ser Lys Met Tyr Ala Arg 
305                 310                 315                 320 


His Arg Lys Ile Tyr Thr Lys Lys His His Ser Gln Thr Ser Leu Lys 
                325                 330                 335     


Val Glu Asn Leu Glu Gln Asp Asn Gly Trp Lys Ser Met Ser Gln Glu 
            340                 345                 350         


His Leu Asn Gly Asn Val Leu Ser Gln Leu Glu Lys Val Phe Tyr His 
        355                 360                 365             


Leu Pro Thr Gly Cys Gln Glu Ile Ala Glu Val Glu Val Arg Met Ile 
    370                 375                 380                 


Asp Phe Ala His Val Phe Pro Ser Asn Thr Ile Asp Glu Gly Tyr Val 
385                 390                 395                 400 


Tyr Gly Leu Lys His Leu Ile Ser Val Leu Arg Ser Ile Leu Asp Asn 
                405                 410                 415     


<210>  5549
<211>  1015
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPO11__Homo_sapiens__NP_001128251

<400>  5549

Met Val Gln Pro Ile Ile His Leu Gly Tyr Val Val Tyr Ser Leu Leu 
1               5                   10                  15      


Tyr Leu Gly Tyr Lys Pro Val Gln His Val Thr Ala Leu Asn Thr Val 
            20                  25                  30          


Ser Ser Cys His Lys Met Val Ser Met Asp Leu Asn Ser Ala Ser Thr 
        35                  40                  45              


Val Val Leu Gln Val Leu Thr Gln Ala Thr Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Leu Lys Pro Ala Glu Glu Gln Leu Lys Gln Trp Glu Thr Gln Pro Gly 
65                  70                  75                  80  


Phe Tyr Ser Val Leu Leu Asn Ile Phe Thr Asn His Thr Leu Asp Ile 
                85                  90                  95      


Asn Val Arg Trp Leu Ala Val Leu Tyr Phe Lys His Gly Ile Asp Arg 
            100                 105                 110         


Tyr Trp Arg Arg Val Ala Pro His Ala Leu Ser Glu Glu Glu Lys Thr 
        115                 120                 125             


Thr Leu Arg Ala Gly Leu Ile Thr Asn Phe Asn Glu Pro Ile Asn Gln 
    130                 135                 140                 


Ile Ala Thr Gln Ile Ala Val Leu Ile Ala Lys Val Ala Arg Leu Asp 
145                 150                 155                 160 


Cys Pro Arg Gln Trp Pro Glu Leu Ile Pro Thr Leu Ile Glu Ser Val 
                165                 170                 175     


Lys Val Gln Asp Asp Leu Arg Gln His Arg Ala Leu Leu Thr Phe Tyr 
            180                 185                 190         


His Val Thr Lys Thr Leu Ala Ser Lys Arg Leu Ala Ala Asp Arg Lys 
        195                 200                 205             


Leu Phe Tyr Asp Leu Ala Ser Gly Ile Tyr Asn Phe Ala Cys Ser Leu 
    210                 215                 220                 


Trp Asn His His Thr Asp Thr Phe Leu Gln Glu Val Ser Ser Gly Asn 
225                 230                 235                 240 


Glu Ala Ala Ile Leu Ser Ser Leu Glu Arg Thr Leu Leu Ser Leu Lys 
                245                 250                 255     


Val Leu Arg Lys Leu Thr Val Asn Gly Phe Val Glu Pro His Lys Asn 
            260                 265                 270         


Met Glu Val Met Gly Phe Leu His Gly Ile Phe Glu Arg Leu Lys Gln 
        275                 280                 285             


Phe Leu Glu Cys Ser Arg Ser Ile Gly Thr Asp Asn Val Cys Arg Asp 
    290                 295                 300                 


Arg Leu Glu Lys Thr Ile Ile Leu Phe Thr Lys Val Leu Leu Asp Phe 
305                 310                 315                 320 


Leu Asp Gln His Pro Phe Ser Phe Thr Pro Leu Ile Gln Arg Ser Leu 
                325                 330                 335     


Glu Phe Ser Val Ser Tyr Val Phe Thr Glu Val Gly Glu Gly Val Thr 
            340                 345                 350         


Phe Glu Arg Phe Ile Val Gln Cys Met Asn Leu Ile Lys Met Ile Val 
        355                 360                 365             


Lys Asn Tyr Ala Tyr Lys Pro Ser Lys Asn Phe Glu Asp Ser Ser Pro 
    370                 375                 380                 


Glu Thr Leu Glu Ala His Lys Ile Lys Met Ala Phe Phe Thr Tyr Pro 
385                 390                 395                 400 


Thr Leu Thr Glu Ile Cys Arg Arg Leu Val Ser His Tyr Phe Leu Leu 
                405                 410                 415     


Thr Glu Glu Glu Leu Thr Met Trp Glu Glu Asp Pro Glu Gly Phe Thr 
            420                 425                 430         


Val Glu Glu Thr Gly Gly Asp Ser Trp Lys Tyr Ser Leu Arg Pro Cys 
        435                 440                 445             


Thr Glu Val Leu Phe Ile Asp Ile Phe His Glu Tyr Asn Gln Thr Leu 
    450                 455                 460                 


Thr Pro Val Leu Leu Glu Met Met Gln Thr Leu Gln Gly Pro Thr Asn 
465                 470                 475                 480 


Val Glu Asp Met Asn Ala Leu Leu Ile Lys Asp Ala Val Tyr Asn Ala 
                485                 490                 495     


Val Gly Leu Ala Ala Tyr Glu Leu Phe Asp Ser Val Asp Phe Asp Gln 
            500                 505                 510         


Trp Phe Lys Asn Gln Leu Leu Pro Glu Leu Gln Val Ile His Asn Arg 
        515                 520                 525             


Tyr Lys Pro Leu Arg Arg Arg Val Ile Trp Leu Ile Gly Gln Trp Ile 
    530                 535                 540                 


Ser Val Lys Phe Lys Ser Asp Leu Arg Pro Met Leu Tyr Glu Ala Ile 
545                 550                 555                 560 


Cys Asn Leu Leu Gln Asp Gln Asp Leu Val Val Arg Ile Glu Thr Ala 
                565                 570                 575     


Thr Thr Leu Lys Leu Thr Val Asp Asp Phe Glu Phe Arg Thr Asp Gln 
            580                 585                 590         


Phe Leu Pro Tyr Leu Glu Thr Met Phe Thr Leu Leu Phe Gln Leu Leu 
        595                 600                 605             


Gln Gln Val Thr Glu Cys Asp Thr Lys Met His Val Leu His Val Leu 
    610                 615                 620                 


Ser Cys Val Ile Glu Arg Val Asn Met Gln Ile Arg Pro Tyr Val Gly 
625                 630                 635                 640 


Cys Leu Val Gln Tyr Leu Pro Leu Leu Trp Lys Gln Ser Glu Glu His 
                645                 650                 655     


Asn Met Leu Arg Cys Ala Ile Leu Thr Thr Leu Ile His Leu Val Gln 
            660                 665                 670         


Gly Leu Gly Ala Asp Ser Lys Asn Leu Tyr Pro Phe Leu Leu Pro Val 
        675                 680                 685             


Ile Gln Leu Ser Thr Asp Val Ser Gln Pro Pro His Val Tyr Leu Leu 
    690                 695                 700                 


Glu Asp Gly Leu Glu Leu Trp Leu Val Thr Leu Glu Asn Ser Pro Cys 
705                 710                 715                 720 


Ile Thr Pro Glu Leu Leu Arg Ile Phe Gln Asn Met Ser Pro Leu Leu 
                725                 730                 735     


Glu Leu Ser Ser Glu Asn Leu Arg Thr Cys Phe Lys Ile Ile Asn Gly 
            740                 745                 750         


Tyr Ile Phe Leu Ser Ser Thr Glu Phe Leu Gln Thr Tyr Ala Val Gly 
        755                 760                 765             


Leu Cys Gln Ser Phe Cys Glu Leu Leu Lys Glu Ile Thr Thr Glu Gly 
    770                 775                 780                 


Gln Val Gln Val Leu Lys Val Val Glu Asn Ala Leu Lys Val Asn Pro 
785                 790                 795                 800 


Ile Leu Gly Pro Gln Met Phe Gln Pro Ile Leu Pro Tyr Val Phe Lys 
                805                 810                 815     


Gly Ile Ile Glu Gly Glu Arg Tyr Pro Val Val Met Ser Thr Tyr Leu 
            820                 825                 830         


Gly Val Met Gly Arg Val Leu Leu Gln Asn Thr Ser Phe Phe Ser Ser 
        835                 840                 845             


Leu Leu Asn Glu Met Ala His Lys Phe Asn Gln Glu Met Asp Gln Leu 
    850                 855                 860                 


Leu Gly Asn Met Ile Glu Met Trp Val Asp Arg Met Asp Asn Ile Thr 
865                 870                 875                 880 


Gln Pro Glu Arg Arg Lys Leu Ser Ala Leu Ala Leu Leu Ser Leu Leu 
                885                 890                 895     


Pro Ser Asp Asn Ser Val Ile Gln Asp Lys Phe Cys Gly Ile Ile Asn 
            900                 905                 910         


Ile Ser Val Glu Gly Leu His Asp Val Met Thr Glu Asp Pro Glu Thr 
        915                 920                 925             


Gly Thr Tyr Lys Asp Cys Met Leu Met Ser His Leu Glu Glu Pro Lys 
    930                 935                 940                 


Val Thr Glu Asp Glu Glu Pro Pro Thr Glu Gln Asp Lys Arg Lys Lys 
945                 950                 955                 960 


Met Leu Ala Leu Lys Asp Pro Val His Thr Val Ser Leu Gln Gln Phe 
                965                 970                 975     


Ile Tyr Glu Lys Leu Lys Ala Gln Gln Glu Met Leu Gly Glu Gln Gly 
            980                 985                 990         


Phe Gln Ser Leu Met Glu Thr Val  Asp Thr Glu Ile Val  Thr Gln Leu 
        995                 1000                 1005             


Gln Glu  Phe Leu Gln Gly Phe  
    1010                 1015 


<210>  5550
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPO13__Homo_sapiens__XP_011540763

<400>  5550

Met Glu Thr Ser His Gly Ile Cys Arg Ile Ala Val Ala Leu Gly Glu 
1               5                   10                  15      


Asn His Ser Arg Ala Leu Leu Asp Gln Val Glu His Trp Gln Ser Phe 
            20                  25                  30          


Leu Ala Leu Val Asn Met Ile Met Phe Cys Thr Gly Ile Pro Gly His 
        35                  40                  45              


Tyr Pro Val Asn Glu Thr Thr Ser Ser Leu Thr Leu Thr Phe Trp Tyr 
    50                  55                  60                  


Thr Leu Gln Asp Asp Ile Leu Ser Phe Glu Ala Glu Lys Gln Ala Val 
65                  70                  75                  80  


Tyr Gln Gln Val Tyr Arg Pro Val Tyr Phe Gln Leu Val Asp Val Leu 
                85                  90                  95      


Leu His Lys Ala Gln Phe Pro Ser Asp Glu Glu Tyr Gly Phe Trp Ser 
            100                 105                 110         


Ser Asp Glu Lys Glu Gln Phe Arg Ile Tyr Arg Val Asp Ile Ser Asp 
        115                 120                 125             


Thr Leu Met Tyr Val Tyr Glu Met Leu Gly Ala Glu Leu Leu Ser Asn 
    130                 135                 140                 


Leu Tyr Asp Lys Leu Gly Arg Leu Leu Thr Ser Ser Glu Glu Pro Tyr 
145                 150                 155                 160 


Ser Trp Gln His Thr Glu Ala Leu Leu Tyr Gly Phe Gln Ser Ile Ala 
                165                 170                 175     


Glu Thr Ile Asp Val Asn Tyr Ser Asp Val Val Pro Gly Leu Ile Gly 
            180                 185                 190         


Leu Ile Pro Arg Ile Ser Ile Ser Asn Val Gln Leu Ala Asp Thr Val 
        195                 200                 205             


Met Phe Thr Ile Gly Ala Leu Ser Glu Trp Leu Ala Asp His Pro Val 
    210                 215                 220                 


Met Ile Asn Ser Val Leu Pro Leu Val Leu His Ala Leu Gly Asn Pro 
225                 230                 235                 240 


Glu Leu Ser Val Ser Ser Val Ser Thr Leu Lys Lys Ile Cys Arg Glu 
                245                 250                 255     


Cys Lys Tyr Asp Leu Pro Pro Tyr Ala Ala Asn Ile Val Ala Val Ser 
            260                 265                 270         


Gln Asp Val Leu Met Lys Gln Ile His Lys Thr Ser Gln Cys Met Trp 
        275                 280                 285             


Leu Met Gln Ala Leu Gly Phe Leu Leu Ser Ala Leu Gln Val Glu Glu 
    290                 295                 300                 


Ile Leu Lys Asn Leu His Ser Leu Ile Ser Pro Tyr Ile Gln Gln Leu 
305                 310                 315                 320 


Glu Lys Leu Ala Glu Glu Ile Pro Asn Pro Ser Asn Lys Leu Ala Ile 
                325                 330                 335     


Val His Ile Leu Gly Leu Leu Ser Asn Leu Phe Thr Thr Leu Asp Ile 
            340                 345                 350         


Ser His His Glu Asp Asp His Glu Gly Pro Glu Leu Arg Lys Leu Pro 
        355                 360                 365             


Val Pro Gln Gly Pro Asn Pro Val Val Val Val Leu Gln Gln Val Phe 
    370                 375                 380                 


Gln Leu Ile Gln Lys Val Leu Ser Lys Trp Leu Asn Asp Ala Gln Val 
385                 390                 395                 400 


Val Glu Ala Val Cys Ala Ile Phe Glu Lys Ser Val Lys Thr Leu Leu 
                405                 410                 415     


Asp Asp Phe Ala Pro Met Val Pro Gln Leu Cys Glu Met Leu Gly Arg 
            420                 425                 430         


Met Tyr Ser Thr Ile Pro Gln Ala Ser Ala Leu Asp Leu Thr Arg Gln 
        435                 440                 445             


Leu Val His Ile Phe Ala His Glu Pro Ala His Phe Pro Pro Ile Glu 
    450                 455                 460                 


Ala Leu Phe Leu Leu Val Thr Ser Val Thr Leu Thr Leu Phe Gln Gln 
465                 470                 475                 480 


Gly Pro Arg Asp His Pro Asp Ile Val Asp Ser Phe Met Gln Leu Leu 
                485                 490                 495     


Ala Gln Ala Leu Lys Arg Lys Pro Asp Leu Phe Leu Cys Glu Arg Leu 
            500                 505                 510         


Asp Val Lys Ala Val Phe Gln Cys Ala Val Leu Ala Leu Lys Phe Pro 
        515                 520                 525             


Glu Ala Pro Thr Val Lys Ala Ser Cys Gly Phe Phe Thr Glu Leu Leu 
    530                 535                 540                 


Pro Arg Cys Gly Glu Val Glu Ser Val Gly Lys Val Val Gln Glu Asp 
545                 550                 555                 560 


Gly Arg Met Leu Leu Ile Ala Val Leu Glu Ala Ile Gly Gly Gln Ala 
                565                 570                 575     


Ser Arg Ser Leu Met Asp Cys Phe Ala Asp Ile Leu Phe Ala Leu Asn 
            580                 585                 590         


Lys His Cys Phe Ser Leu Leu Ser Met Trp Ile Lys Glu Ala Leu Gln 
        595                 600                 605             


Pro Pro Gly Phe Pro Ser Ala Arg Leu Ser Pro Glu Gln Lys Asp Thr 
    610                 615                 620                 


Phe Ser Gln Gln Ile Leu Arg Glu Arg Val Asn Lys Arg Arg Val Lys 
625                 630                 635                 640 


Glu Met Val Lys Glu Phe Thr Leu Leu Cys Arg Gly Leu His Gly Thr 
                645                 650                 655     


Asp Tyr Thr Ala Asp Tyr 
            660         


<210>  5551
<211>  1038
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPO7__Homo_sapiens__NP_006382

<400>  5551

Met Asp Pro Asn Thr Ile Ile Glu Ala Leu Arg Gly Thr Met Asp Pro 
1               5                   10                  15      


Ala Leu Arg Glu Ala Ala Glu Arg Gln Leu Asn Glu Ala His Lys Ser 
            20                  25                  30          


Leu Asn Phe Val Ser Thr Leu Leu Gln Ile Thr Met Ser Glu Gln Leu 
        35                  40                  45              


Asp Leu Pro Val Arg Gln Ala Gly Val Ile Tyr Leu Lys Asn Met Ile 
    50                  55                  60                  


Thr Gln Tyr Trp Pro Asp Arg Glu Thr Ala Pro Gly Asp Ile Ser Pro 
65                  70                  75                  80  


Tyr Thr Ile Pro Glu Glu Asp Arg His Cys Ile Arg Glu Asn Ile Val 
                85                  90                  95      


Glu Ala Ile Ile His Ser Pro Glu Leu Ile Arg Val Gln Leu Thr Thr 
            100                 105                 110         


Cys Ile His His Ile Ile Lys His Asp Tyr Pro Ser Arg Trp Thr Ala 
        115                 120                 125             


Ile Val Asp Lys Ile Gly Phe Tyr Leu Gln Ser Asp Asn Ser Ala Cys 
    130                 135                 140                 


Trp Leu Gly Ile Leu Leu Cys Leu Tyr Gln Leu Val Lys Asn Tyr Glu 
145                 150                 155                 160 


Tyr Lys Lys Pro Glu Glu Arg Ser Pro Leu Val Ala Ala Met Gln His 
                165                 170                 175     


Phe Leu Pro Val Leu Lys Asp Arg Phe Ile Gln Leu Leu Ser Asp Gln 
            180                 185                 190         


Ser Asp Gln Ser Val Leu Ile Gln Lys Gln Ile Phe Lys Ile Phe Tyr 
        195                 200                 205             


Ala Leu Val Gln Tyr Thr Leu Pro Leu Glu Leu Ile Asn Gln Gln Asn 
    210                 215                 220                 


Leu Thr Glu Trp Ile Glu Ile Leu Lys Thr Val Val Asn Arg Asp Val 
225                 230                 235                 240 


Pro Asn Glu Thr Leu Gln Val Glu Glu Asp Asp Arg Pro Glu Leu Pro 
                245                 250                 255     


Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Leu Ala Arg Leu Phe 
            260                 265                 270         


Glu Arg Tyr Gly Ser Pro Gly Asn Val Ser Lys Glu Tyr Asn Glu Phe 
        275                 280                 285             


Ala Glu Val Phe Leu Lys Ala Phe Ala Val Gly Val Gln Gln Val Leu 
    290                 295                 300                 


Leu Lys Val Leu Tyr Gln Tyr Lys Glu Lys Gln Tyr Met Ala Pro Arg 
305                 310                 315                 320 


Val Leu Gln Gln Thr Leu Asn Tyr Ile Asn Gln Gly Val Ser His Ala 
                325                 330                 335     


Leu Thr Trp Lys Asn Leu Lys Pro His Ile Gln Gly Ile Ile Gln Asp 
            340                 345                 350         


Val Ile Phe Pro Leu Met Cys Tyr Thr Asp Ala Asp Glu Glu Leu Trp 
        355                 360                 365             


Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe Asp Val Phe Glu 
    370                 375                 380                 


Asp Phe Ile Ser Pro Thr Thr Ala Ala Gln Thr Leu Leu Phe Thr Ala 
385                 390                 395                 400 


Cys Ser Lys Arg Lys Glu Val Leu Gln Lys Thr Met Gly Phe Cys Tyr 
                405                 410                 415     


Gln Ile Leu Thr Glu Pro Asn Ala Asp Pro Arg Lys Lys Asp Gly Ala 
            420                 425                 430         


Leu His Met Ile Gly Ser Leu Ala Glu Ile Leu Leu Lys Lys Lys Ile 
        435                 440                 445             


Tyr Lys Asp Gln Met Glu Tyr Met Leu Gln Asn His Val Phe Pro Leu 
    450                 455                 460                 


Phe Ser Ser Glu Leu Gly Tyr Met Arg Ala Arg Ala Cys Trp Val Leu 
465                 470                 475                 480 


His Tyr Phe Cys Glu Val Lys Phe Lys Ser Asp Gln Asn Leu Gln Thr 
                485                 490                 495     


Ala Leu Glu Leu Thr Arg Arg Cys Leu Ile Asp Asp Arg Glu Met Pro 
            500                 505                 510         


Val Lys Val Glu Ala Ala Ile Ala Leu Gln Val Leu Ile Ser Asn Gln 
        515                 520                 525             


Glu Lys Ala Lys Glu Tyr Ile Thr Pro Phe Ile Arg Pro Val Met Gln 
    530                 535                 540                 


Ala Leu Leu His Ile Ile Arg Glu Thr Glu Asn Asp Asp Leu Thr Asn 
545                 550                 555                 560 


Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Glu Glu Val Thr Pro Ile 
                565                 570                 575     


Ala Val Glu Met Thr Gln His Leu Ala Met Thr Phe Asn Gln Val Ile 
            580                 585                 590         


Gln Thr Gly Pro Asp Glu Glu Gly Ser Asp Asp Lys Ala Val Thr Ala 
        595                 600                 605             


Met Gly Ile Leu Asn Thr Ile Asp Thr Leu Leu Ser Val Val Glu Asp 
    610                 615                 620                 


His Lys Glu Ile Thr Gln Gln Leu Glu Gly Ile Cys Leu Gln Val Ile 
625                 630                 635                 640 


Gly Thr Val Leu Gln Gln His Val Leu Glu Phe Tyr Glu Glu Ile Phe 
                645                 650                 655     


Ser Leu Ala His Ser Leu Thr Cys Gln Gln Val Ser Pro Gln Met Trp 
            660                 665                 670         


Gln Leu Leu Pro Leu Val Phe Glu Val Phe Gln Gln Asp Gly Phe Asp 
        675                 680                 685             


Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr Val Thr Val Asp 
    690                 695                 700                 


Thr Asp Thr Leu Leu Ser Asp Thr Lys Tyr Leu Glu Met Ile Tyr Ser 
705                 710                 715                 720 


Met Cys Lys Lys Val Leu Thr Gly Val Ala Gly Glu Asp Ala Glu Cys 
                725                 730                 735     


His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln Cys Lys Gly Arg 
            740                 745                 750         


Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Glu Ala Ala Leu Glu Arg 
        755                 760                 765             


Leu Thr Arg Glu Val Lys Thr Ser Glu Leu Arg Thr Met Cys Leu Gln 
    770                 775                 780                 


Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro His Leu Leu Leu Asn Thr 
785                 790                 795                 800 


Leu Glu Asn Leu Arg Phe Pro Asn Asn Val Glu Pro Val Thr Asn His 
                805                 810                 815     


Phe Ile Thr Gln Trp Leu Asn Asp Val Asp Cys Phe Leu Gly Leu His 
            820                 825                 830         


Asp Arg Lys Met Cys Val Leu Gly Leu Cys Ala Leu Ile Asp Met Glu 
        835                 840                 845             


Gln Ile Pro Gln Val Leu Asn Gln Val Ser Gly Gln Ile Leu Pro Ala 
    850                 855                 860                 


Phe Ile Leu Leu Phe Asn Gly Leu Lys Arg Ala Tyr Ala Cys His Ala 
865                 870                 875                 880 


Glu His Glu Asn Asp Ser Asp Asp Asp Asp Glu Ala Glu Asp Asp Asp 
                885                 890                 895     


Glu Thr Glu Glu Leu Gly Ser Asp Glu Asp Asp Ile Asp Glu Asp Gly 
            900                 905                 910         


Gln Glu Tyr Leu Glu Ile Leu Ala Lys Gln Ala Gly Glu Asp Gly Asp 
        915                 920                 925             


Asp Glu Asp Trp Glu Glu Asp Asp Ala Glu Glu Thr Ala Leu Glu Gly 
    930                 935                 940                 


Tyr Ser Thr Ile Ile Asp Asp Glu Asp Asn Pro Val Asp Glu Tyr Gln 
945                 950                 955                 960 


Ile Phe Lys Ala Ile Phe Gln Thr Ile Gln Asn Arg Asn Pro Val Trp 
                965                 970                 975     


Tyr Gln Ala Leu Thr His Gly Leu Asn Glu Glu Gln Arg Lys Gln Leu 
            980                 985                 990         


Gln Asp Ile Ala Thr Leu Ala Asp  Gln Arg Arg Ala Ala  His Glu Ser 
        995                 1000                 1005             


Lys Met  Ile Glu Lys His Gly  Gly Tyr Lys Phe Ser  Ala Pro Val 
    1010                 1015                 1020             


Val Pro  Ser Ser Phe Asn Phe  Gly Gly Pro Ala Pro  Gly Met Asn 
    1025                 1030                 1035             


<210>  5552
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPO8__Homo_sapiens__NP_001177924

<400>  5552

Met Glu Ser Leu Thr Leu Lys Gly Tyr Ala Leu Pro Leu Gln Leu Val 
1               5                   10                  15      


Asn Asn Gln Thr Met Thr Thr Trp Met Glu Ile Phe Arg Thr Ile Ile 
            20                  25                  30          


Asp Arg Thr Val Pro Pro Glu Thr Leu His Ile Asp Glu Asp Asp Arg 
        35                  40                  45              


Pro Glu Leu Val Trp Trp Lys Cys Lys Lys Trp Ala Leu His Ile Val 
    50                  55                  60                  


Ala Arg Leu Phe Glu Arg Tyr Gly Ser Pro Gly Asn Val Thr Lys Glu 
65                  70                  75                  80  


Tyr Phe Glu Phe Ser Glu Phe Phe Leu Lys Thr Tyr Ala Val Gly Ile 
                85                  90                  95      


Gln Gln Val Leu Leu Lys Ile Leu Asp Gln Tyr Arg Gln Lys Glu Tyr 
            100                 105                 110         


Val Ala Pro Arg Val Leu Gln Gln Ala Phe Asn Tyr Leu Asn Gln Gly 
        115                 120                 125             


Val Val His Ser Ile Thr Trp Lys Gln Met Lys Pro His Ile Gln Asn 
    130                 135                 140                 


Ile Ser Glu Asp Val Ile Phe Ser Val Met Cys Tyr Lys Asp Glu Asp 
145                 150                 155                 160 


Glu Glu Leu Trp Gln Glu Asp Pro Tyr Glu Tyr Ile Arg Met Lys Phe 
                165                 170                 175     


Asp Ile Phe Glu Asp Tyr Ala Ser Pro Thr Thr Ala Ala Gln Thr Leu 
            180                 185                 190         


Leu Tyr Thr Ala Ala Lys Lys Arg Lys Glu Val Leu Pro Lys Met Met 
        195                 200                 205             


Ala Phe Cys Tyr Gln Ile Leu Thr Asp Pro Asn Phe Asp Pro Arg Lys 
    210                 215                 220                 


Lys Asp Gly Ala Leu His Val Ile Gly Ser Leu Ala Glu Ile Leu Leu 
225                 230                 235                 240 


Lys Lys Ser Leu Phe Lys Asp Gln Met Glu Leu Phe Leu Gln Asn His 
                245                 250                 255     


Val Phe Pro Leu Leu Leu Ser Asn Leu Gly Tyr Leu Arg Ala Arg Ser 
            260                 265                 270         


Cys Trp Val Leu His Ala Phe Ser Ser Leu Lys Phe His Asn Glu Leu 
        275                 280                 285             


Asn Leu Arg Asn Ala Val Glu Leu Ala Lys Lys Ser Leu Ile Glu Asp 
    290                 295                 300                 


Lys Glu Met Pro Val Lys Val Glu Ala Ala Leu Ala Leu Gln Ser Leu 
305                 310                 315                 320 


Ile Ser Asn Gln Ile Gln Ala Lys Glu Tyr Met Lys Pro His Val Arg 
                325                 330                 335     


Pro Ile Met Gln Glu Leu Leu His Ile Val Arg Glu Thr Glu Asn Asp 
            340                 345                 350         


Asp Val Thr Asn Val Ile Gln Lys Met Ile Cys Glu Tyr Ser Gln Glu 
        355                 360                 365             


Val Ala Ser Ile Ala Val Asp Met Thr Gln His Leu Ala Glu Ile Phe 
    370                 375                 380                 


Gly Lys Val Leu Gln Ser Asp Glu Tyr Glu Glu Val Glu Asp Lys Thr 
385                 390                 395                 400 


Val Met Ala Met Gly Ile Leu His Thr Ile Asp Thr Ile Leu Thr Val 
                405                 410                 415     


Val Glu Asp His Lys Glu Ile Thr Gln Gln Leu Glu Asn Ile Cys Leu 
            420                 425                 430         


Arg Ile Ile Asp Leu Val Leu Gln Lys His Val Ile Glu Phe Tyr Glu 
        435                 440                 445             


Glu Ile Leu Ser Leu Ala Tyr Ser Leu Thr Cys His Ser Ile Ser Pro 
    450                 455                 460                 


Gln Met Trp Gln Leu Leu Gly Ile Leu Tyr Glu Val Phe Gln Gln Asp 
465                 470                 475                 480 


Cys Phe Glu Tyr Phe Thr Asp Met Met Pro Leu Leu His Asn Tyr Val 
                485                 490                 495     


Thr Ile Asp Thr Asp Thr Leu Leu Ser Asn Ala Lys His Leu Glu Ile 
            500                 505                 510         


Leu Phe Thr Met Cys Arg Lys Val Leu Cys Gly Asp Ala Gly Glu Asp 
        515                 520                 525             


Ala Glu Cys His Ala Ala Lys Leu Leu Glu Val Ile Ile Leu Gln Cys 
    530                 535                 540                 


Lys Gly Arg Gly Ile Asp Gln Cys Ile Pro Leu Phe Val Gln Leu Val 
545                 550                 555                 560 


Leu Glu Arg Leu Thr Arg Gly Val Lys Thr Ser Glu Leu Arg Thr Met 
                565                 570                 575     


Cys Leu Gln Val Ala Ile Ala Ala Leu Tyr Tyr Asn Pro Asp Leu Leu 
            580                 585                 590         


Leu His Thr Leu Glu Arg Ile Gln Leu Pro His Asn Pro Gly Pro Ile 
        595                 600                 605             


Thr Val Gln Phe Ile Asn Gln Trp Met Asn Asp Thr Asp Cys Phe Leu 
    610                 615                 620                 


Gly His His Asp Arg Lys Met Cys Ile Ile Gly Leu Ser Ile Leu Leu 
625                 630                 635                 640 


Glu Leu Gln Asn Arg Pro Pro Ala Val Asp Ala Val Val Gly Gln Ile 
                645                 650                 655     


Val Pro Ser Ile Leu Phe Leu Phe Leu Gly Leu Lys Gln Val Cys Ala 
            660                 665                 670         


Thr Arg Gln Leu Val Asn Arg Glu Asp Arg Ser Lys Ala Glu Lys Ala 
        675                 680                 685             


Asp Met Glu Glu Asn Glu Glu Ile Ser Ser Asp Glu Glu Glu Thr Asn 
    690                 695                 700                 


Val Thr Ala Gln Ala Met Gln Ser Asn Asn Gly Arg Gly Glu Asp Glu 
705                 710                 715                 720 


Glu Glu Glu Asp Asp Asp Trp Asp Glu Glu Val Leu Glu Glu Thr Ala 
                725                 730                 735     


Leu Glu Gly Phe Ser Thr Pro Leu Asp Leu Asp Asn Ser Val Asp Glu 
            740                 745                 750         


Tyr Gln Phe Phe Thr Gln Ala Leu Ile Thr Val Gln Ser Arg Asp Ala 
        755                 760                 765             


Ala Trp Tyr Gln Leu Leu Met Ala Pro Leu Ser Glu Asp Gln Arg Thr 
    770                 775                 780                 


Ala Leu Gln Glu Val Tyr Thr Leu Ala Glu His Arg Arg Thr Val Ala 
785                 790                 795                 800 


Glu Ala Lys Lys Lys Ile Glu Gln Gln Gly Gly Phe Thr Phe Glu Asn 
                805                 810                 815     


Lys Gly Val Leu Ser Ala Phe Asn Phe Gly Thr Val Pro Ser Asn Asn 
            820                 825                 830         


<210>  5553
<211>  1041
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IPO9__Homo_sapiens__NP_060555

<400>  5553

Met Ala Ala Ala Ala Ala Ala Gly Ala Ala Ser Gly Leu Pro Gly Pro 
1               5                   10                  15      


Val Ala Gln Gly Leu Lys Glu Ala Leu Val Asp Thr Leu Thr Gly Ile 
            20                  25                  30          


Leu Ser Pro Val Gln Glu Val Arg Ala Ala Ala Glu Glu Gln Ile Lys 
        35                  40                  45              


Val Leu Glu Val Thr Glu Glu Phe Gly Val His Leu Ala Glu Leu Thr 
    50                  55                  60                  


Val Asp Pro Gln Gly Ala Leu Ala Ile Arg Gln Leu Ala Ser Val Ile 
65                  70                  75                  80  


Leu Lys Gln Tyr Val Glu Thr His Trp Cys Ala Gln Ser Glu Lys Phe 
                85                  90                  95      


Arg Pro Pro Glu Thr Thr Glu Arg Ala Lys Ile Val Ile Arg Glu Leu 
            100                 105                 110         


Leu Pro Asn Gly Leu Arg Glu Ser Ile Ser Lys Val Arg Ser Ser Val 
        115                 120                 125             


Ala Tyr Ala Val Ser Ala Ile Ala His Trp Asp Trp Pro Glu Ala Trp 
    130                 135                 140                 


Pro Gln Leu Phe Asn Leu Leu Met Glu Met Leu Val Ser Gly Asp Leu 
145                 150                 155                 160 


Asn Ala Val His Gly Ala Met Arg Val Leu Thr Glu Phe Thr Arg Glu 
                165                 170                 175     


Val Thr Asp Thr Gln Met Pro Leu Val Ala Pro Val Ile Leu Pro Glu 
            180                 185                 190         


Met Tyr Lys Ile Phe Thr Met Ala Glu Val Tyr Gly Ile Arg Thr Arg 
        195                 200                 205             


Ser Arg Ala Val Glu Ile Phe Thr Thr Cys Ala His Met Ile Cys Asn 
    210                 215                 220                 


Met Glu Glu Leu Glu Lys Gly Ala Ala Lys Val Leu Ile Phe Pro Val 
225                 230                 235                 240 


Val Gln Gln Phe Thr Glu Ala Phe Val Gln Ala Leu Gln Ile Pro Asp 
                245                 250                 255     


Gly Pro Thr Ser Asp Ser Gly Phe Lys Met Glu Val Leu Lys Ala Val 
            260                 265                 270         


Thr Ala Leu Val Lys Asn Phe Pro Lys His Met Val Ser Ser Met Gln 
        275                 280                 285             


Gln Ile Leu Pro Ile Val Trp Asn Thr Leu Thr Glu Ser Ala Ala Phe 
    290                 295                 300                 


Tyr Val Arg Thr Glu Val Asn Tyr Thr Glu Glu Val Glu Asp Pro Val 
305                 310                 315                 320 


Asp Ser Asp Gly Glu Val Leu Gly Phe Glu Asn Leu Val Phe Ser Ile 
                325                 330                 335     


Phe Glu Phe Val His Ala Leu Leu Glu Asn Ser Lys Phe Lys Ser Thr 
            340                 345                 350         


Val Lys Lys Ala Leu Pro Glu Leu Ile Tyr Tyr Ile Ile Leu Tyr Met 
        355                 360                 365             


Gln Ile Thr Glu Glu Gln Ile Lys Val Trp Thr Ala Asn Pro Gln Gln 
    370                 375                 380                 


Phe Val Glu Asp Glu Asp Asp Asp Thr Phe Ser Tyr Thr Val Arg Ile 
385                 390                 395                 400 


Ala Ala Gln Asp Leu Leu Leu Ala Val Ala Thr Asp Phe Gln Asn Glu 
                405                 410                 415     


Ser Ala Ala Ala Leu Ala Ala Ala Ala Thr Arg His Leu Gln Glu Ala 
            420                 425                 430         


Glu Gln Thr Lys Asn Ser Gly Thr Glu His Trp Trp Lys Ile His Glu 
        435                 440                 445             


Ala Cys Met Leu Ala Leu Gly Ser Val Lys Ala Ile Ile Thr Asp Ser 
    450                 455                 460                 


Val Lys Asn Gly Arg Ile His Phe Asp Met His Gly Phe Leu Thr Asn 
465                 470                 475                 480 


Val Ile Leu Ala Asp Leu Asn Leu Ser Val Ser Pro Phe Leu Leu Gly 
                485                 490                 495     


Arg Ala Leu Trp Ala Ala Ser Arg Phe Thr Val Ala Met Ser Pro Glu 
            500                 505                 510         


Leu Ile Gln Gln Phe Leu Gln Ala Thr Val Ser Gly Leu His Glu Thr 
        515                 520                 525             


Gln Pro Pro Ser Val Arg Ile Ser Ala Val Arg Ala Ile Trp Gly Tyr 
    530                 535                 540                 


Cys Asp Gln Leu Lys Val Ser Glu Ser Thr His Val Leu Gln Pro Phe 
545                 550                 555                 560 


Leu Pro Ser Ile Leu Asp Gly Leu Ile His Leu Ala Ala Gln Phe Ser 
                565                 570                 575     


Ser Glu Val Leu Asn Leu Val Met Glu Thr Leu Cys Ile Val Cys Thr 
            580                 585                 590         


Val Asp Pro Glu Phe Thr Ala Ser Met Glu Ser Lys Ile Cys Pro Phe 
        595                 600                 605             


Thr Ile Ala Ile Phe Leu Lys Tyr Ser Asn Asp Pro Val Val Ala Ser 
    610                 615                 620                 


Leu Ala Gln Asp Ile Phe Lys Glu Leu Ser Gln Ile Glu Ala Cys Gln 
625                 630                 635                 640 


Gly Pro Met Gln Met Arg Leu Ile Pro Thr Leu Val Ser Ile Met Gln 
                645                 650                 655     


Ala Pro Ala Asp Lys Ile Pro Ala Gly Leu Cys Ala Thr Ala Ile Asp 
            660                 665                 670         


Ile Leu Thr Thr Val Val Arg Asn Thr Lys Pro Pro Leu Ser Gln Leu 
        675                 680                 685             


Leu Ile Cys Gln Ala Phe Pro Ala Val Ala Gln Cys Thr Leu His Thr 
    690                 695                 700                 


Asp Asp Asn Ala Thr Met Gln Asn Gly Gly Glu Cys Leu Arg Ala Tyr 
705                 710                 715                 720 


Val Ser Val Thr Leu Glu Gln Val Ala Gln Trp His Asp Glu Gln Gly 
                725                 730                 735     


His Asn Gly Leu Trp Tyr Val Met Gln Val Val Ser Gln Leu Leu Asp 
            740                 745                 750         


Pro Arg Thr Ser Glu Phe Thr Ala Ala Phe Val Gly Arg Leu Val Ser 
        755                 760                 765             


Thr Leu Ile Ser Lys Ala Gly Arg Glu Leu Gly Glu Asn Leu Asp Gln 
    770                 775                 780                 


Ile Leu Arg Ala Ile Leu Ser Lys Met Gln Gln Ala Glu Thr Leu Ser 
785                 790                 795                 800 


Val Met Gln Ser Leu Ile Met Val Phe Ala His Leu Val His Thr Gln 
                805                 810                 815     


Leu Glu Pro Leu Leu Glu Phe Leu Cys Ser Leu Pro Gly Pro Thr Gly 
            820                 825                 830         


Lys Pro Ala Leu Glu Phe Val Met Ala Glu Trp Thr Ser Arg Gln His 
        835                 840                 845             


Leu Phe Tyr Gly Gln Tyr Glu Gly Lys Val Ser Ser Val Ala Leu Cys 
    850                 855                 860                 


Lys Leu Leu Gln His Gly Ile Asn Ala Asp Asp Lys Arg Leu Gln Asp 
865                 870                 875                 880 


Ile Arg Val Lys Gly Glu Glu Ile Tyr Ser Met Asp Glu Gly Ile Arg 
                885                 890                 895     


Thr Arg Ser Lys Ser Ala Lys Asn Pro Glu Arg Trp Thr Asn Ile Pro 
            900                 905                 910         


Leu Leu Val Lys Ile Leu Lys Leu Ile Ile Asn Glu Leu Ser Asn Val 
        915                 920                 925             


Met Glu Ala Asn Ala Ala Arg Gln Ala Thr Pro Ala Glu Trp Ser Gln 
    930                 935                 940                 


Asp Asp Ser Asn Asp Met Trp Glu Asp Gln Glu Glu Glu Glu Glu Glu 
945                 950                 955                 960 


Glu Glu Asp Gly Leu Ala Gly Gln Leu Leu Ser Asp Ile Leu Ala Thr 
                965                 970                 975     


Ser Lys Tyr Glu Glu Asp Tyr Tyr Glu Asp Asp Glu Glu Asp Asp Pro 
            980                 985                 990         


Asp Ala Leu Lys Asp Pro Leu Tyr  Gln Ile Asp Leu Gln  Ala Tyr Leu 
        995                 1000                 1005             


Thr Asp  Phe Leu Cys Gln Phe  Ala Gln Gln Pro Cys  Tyr Ile Met 
    1010                 1015                 1020             


Phe Ser  Gly His Leu Asn Asp  Asn Glu Arg Arg Val  Leu Gln Thr 
    1025                 1030                 1035             


Ile Gly  Ile 
    1040     


<210>  5554
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQCB1__Homo_sapiens__NP_001018864

<400>  5554

Met Lys Pro Thr Gly Thr Asp Pro Arg Ile Leu Ser Ile Ala Ala Glu 
1               5                   10                  15      


Val Ala Lys Ser Pro Glu Gln Asn Val Pro Val Ile Leu Leu Lys Leu 
            20                  25                  30          


Lys Glu Ile Ile Asn Ile Thr Pro Leu Gly Ser Ser Glu Leu Lys Lys 
        35                  40                  45              


Ile Lys Gln Asp Ile Tyr Cys Tyr Asp Leu Ile Gln Tyr Cys Leu Leu 
    50                  55                  60                  


Val Leu Ser Gln Asp Tyr Ser Arg Ile Gln Gly Gly Trp Thr Thr Ile 
65                  70                  75                  80  


Ser Gln Leu Thr Gln Ile Leu Ser His Cys Cys Val Gly Leu Glu Pro 
                85                  90                  95      


Gly Glu Asp Ala Glu Glu Phe Tyr Asn Glu Leu Leu Pro Ser Ala Ala 
            100                 105                 110         


Glu Asn Phe Leu Val Leu Gly Arg Gln Leu Gln Thr Cys Phe Ile Asn 
        115                 120                 125             


Ala Ala Lys Ala Glu Glu Lys Asp Glu Leu Leu His Phe Phe Gln Ile 
    130                 135                 140                 


Val Thr Asp Ser Leu Phe Trp Leu Leu Gly Gly His Val Glu Leu Ile 
145                 150                 155                 160 


Gln Asn Val Leu Gln Ser Asp His Phe Leu His Leu Leu Gln Ala Asp 
                165                 170                 175     


Asn Val Gln Ile Gly Ser Ala Val Met Met Met Leu Gln Asn Ile Leu 
            180                 185                 190         


Gln Ile Asn Ser Gly Asp Leu Leu Arg Ile Gly Arg Lys Ala Leu Tyr 
        195                 200                 205             


Ser Ile Leu Asp Glu Val Ile Phe Lys Leu Phe Ser Thr Pro Ser Pro 
    210                 215                 220                 


Val Ile Arg Ser Thr Ala Thr Lys Leu Leu Leu Leu Met Ala Glu Ser 
225                 230                 235                 240 


His Gln Glu Ile Leu Ile Leu Leu Arg Gln Ser Thr Cys Tyr Lys Gly 
                245                 250                 255     


Leu Arg Arg Leu Leu Ser Lys Gln Glu Thr Gly Thr Glu Phe Ser Gln 
            260                 265                 270         


Glu Leu Arg Gln Leu Val Gly Leu Leu Ser Pro Met Val Tyr Gln Glu 
        275                 280                 285             


Val Glu Glu Gln Lys Leu His Gln Ala Ala Cys Leu Ile Gln Ala Tyr 
    290                 295                 300                 


Trp Lys Gly Phe Gln Thr Arg Lys Arg Leu Lys Lys Leu Pro Ser Ala 
305                 310                 315                 320 


Val Ile Ala Leu Gln Arg Ser Phe Arg Ser Lys Arg Ser Lys Met Leu 
                325                 330                 335     


Leu Glu Ile Asn Arg Gln Lys Glu Glu Glu Asp Leu Lys Leu Gln Leu 
            340                 345                 350         


Gln Leu Gln Arg Gln Arg Ala Met Arg Leu Ser Arg Glu Leu Gln Leu 
        355                 360                 365             


Ser Met Leu Glu Ile Val His Pro Gly Gln Val Glu Lys His Tyr Arg 
    370                 375                 380                 


Glu Met Glu Glu Lys Ser Ala Leu Ile Ile Gln Lys His Trp Arg Gly 
385                 390                 395                 400 


Tyr Arg Glu Arg Lys Asn Phe His Gln Gln Arg Gln Ser Leu Ile Glu 
                405                 410                 415     


Tyr Lys Ala Ala Val Thr Leu Gln Arg Ala Ala Leu Lys Phe Leu Ala 
            420                 425                 430         


Lys Cys Arg Lys Lys Lys Lys Leu Phe Ala Pro Trp Arg Gly Leu Gln 
        435                 440                 445             


Glu Leu Thr Asp Ala Arg Arg Val Glu Leu Lys Lys Arg Val Asp Asp 
    450                 455                 460                 


Tyr Val Arg Arg His Leu Gly Ser Pro Met Ser Asp Val Val Ser Arg 
465                 470                 475                 480 


Glu Leu His Ala Gln Ala Gln Glu Arg Leu Gln His Tyr Phe Met Gly 
                485                 490                 495     


Arg Ala Leu Glu Glu Arg Ala Gln Gln His Arg Glu Ala Leu Ile Ala 
            500                 505                 510         


Gln Ile Ser Thr Asn Val Glu Gln Leu Met Lys Ala Pro Ser Leu Lys 
        515                 520                 525             


Glu Ala Glu Gly Lys Glu Pro Glu Leu Phe Leu Ser Arg Ser Arg Pro 
    530                 535                 540                 


Val Ala Ala Lys Ala Lys Gln Ala His Leu Thr Thr Leu Lys His Ile 
545                 550                 555                 560 


Gln Ala Pro Trp Trp Lys Lys Leu Gly Glu Glu Ser Gly Asp Glu Ile 
                565                 570                 575     


Asp Val Pro Lys Asp Glu Leu Ser Ile Glu Leu Glu Asn Leu Phe Ile 
            580                 585                 590         


Gly Gly Thr Lys Pro Pro 
        595             


<210>  5555
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQCG__Homo_sapiens__NP_001127907

<400>  5555

Met Glu Glu Asp Ser Leu Glu Asp Ser Asn Leu Pro Pro Lys Val Trp 
1               5                   10                  15      


His Ser Glu Met Thr Val Ser Val Thr Gly Glu Pro Pro Ser Thr Val 
            20                  25                  30          


Glu Glu Glu Gly Ile Pro Lys Glu Thr Asp Ile Glu Ile Ile Pro Glu 
        35                  40                  45              


Ile Pro Glu Thr Leu Glu Pro Leu Ser Leu Pro Asp Val Leu Arg Ile 
    50                  55                  60                  


Ser Ala Val Leu Glu Asp Thr Thr Asp Gln Leu Ser Ile Leu Asn Tyr 
65                  70                  75                  80  


Ile Met Pro Val Gln Tyr Glu Gly Arg Gln Ser Ile Cys Val Lys Ser 
                85                  90                  95      


Arg Glu Met Asn Leu Glu Gly Thr Asn Leu Asp Lys Leu Pro Met Ala 
            100                 105                 110         


Ser Thr Ile Thr Lys Ile Pro Ser Pro Leu Ile Thr Glu Glu Gly Pro 
        115                 120                 125             


Asn Leu Pro Glu Ile Arg His Arg Gly Arg Phe Ala Val Glu Phe Asn 
    130                 135                 140                 


Lys Met Gln Asp Leu Val Phe Lys Lys Pro Thr Arg Gln Thr Ile Met 
145                 150                 155                 160 


Thr Thr Glu Thr Leu Lys Lys Ile Gln Ile Asp Arg Gln Phe Phe Ser 
                165                 170                 175     


Asp Val Ile Ala Asp Thr Ile Lys Glu Leu Gln Asp Ser Ala Thr Tyr 
            180                 185                 190         


Asn Ser Leu Leu Gln Ala Leu Ser Lys Glu Arg Glu Asn Lys Met His 
        195                 200                 205             


Phe Tyr Asp Ile Ile Ala Arg Glu Glu Lys Gly Arg Lys Gln Ile Ile 
    210                 215                 220                 


Ser Leu Gln Lys Gln Leu Ile Asn Val Lys Lys Glu Trp Gln Phe Glu 
225                 230                 235                 240 


Val Gln Ser Gln Asn Glu Tyr Ile Ala Asn Leu Lys Asp Gln Leu Gln 
                245                 250                 255     


Glu Met Lys Ala Lys Ser Asn Leu Glu Asn Arg Tyr Met Lys Thr Asn 
            260                 265                 270         


Thr Glu Leu Gln Ile Ala Gln Thr Gln Lys Lys Cys Asn Arg Thr Glu 
        275                 280                 285             


Glu Leu Leu Val Glu Glu Ile Glu Lys Leu Arg Met Lys Thr Glu Glu 
    290                 295                 300                 


Glu Ala Arg Thr His Thr Glu Ile Glu Met Phe Leu Arg Lys Glu Gln 
305                 310                 315                 320 


Gln Lys Leu Glu Glu Arg Leu Glu Phe Trp Met Glu Lys Tyr Asp Lys 
                325                 330                 335     


Asp Thr Glu Met Lys Gln Asn Glu Leu Asn Ala Leu Lys Ala Thr Lys 
            340                 345                 350         


Ala Ser Asp Leu Ala His Leu Gln Asp Leu Ala Lys Met Ile Arg Glu 
        355                 360                 365             


Tyr Glu Gln Val Ile Ile Glu Asp Arg Ile Glu Lys Glu Arg Ser Lys 
    370                 375                 380                 


Lys Lys Val Lys Gln Asp Leu Leu Glu Leu Lys Ser Val Ile Lys Leu 
385                 390                 395                 400 


Gln Ala Trp Trp Arg Gly Thr Met Ile Arg Arg Glu Ile Gly Gly Phe 
                405                 410                 415     


Lys Met Pro Lys Asp Lys Val Asp Ser Lys Asp Ser Lys Gly Lys Gly 
            420                 425                 430         


Lys Gly Lys Asp Lys Arg Arg Gly Lys Lys Lys 
        435                 440             


<210>  5556
<211>  1027
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQCH__Homo_sapiens__NP_001026885

<400>  5556

Met Ala Gln Asn Thr Glu Asn His Asp Pro Val Gly Ser Ile Leu Ile 
1               5                   10                  15      


Gln Ile His Glu Asp Leu Tyr Gln Leu Lys Glu Lys Leu Thr Lys Phe 
            20                  25                  30          


Ser Pro Glu Glu Lys Gly Glu Thr Leu Asp Ile Gln Ser Leu Glu Thr 
        35                  40                  45              


Ala Ile Lys Arg Thr Glu Val Gly Leu Arg Ile His Ile Glu Lys Tyr 
    50                  55                  60                  


Leu Asn Val Val Asn Gln Asn Val Leu Thr Thr Ser Val Asn Asp Glu 
65                  70                  75                  80  


Ser Leu Tyr Thr Pro Gln Ala Ser Lys Trp Leu Leu Pro Thr Val Ile 
                85                  90                  95      


Asp Gln Lys Ser Phe Ile Phe Pro Gln Glu Ser Glu Gly Thr Phe Trp 
            100                 105                 110         


Gln Pro Gln Arg Gln His Ser Ser Ser Leu Pro Val Phe Pro Arg Ala 
        115                 120                 125             


Lys Ile Lys Val Ser Lys Leu Ile Lys Gly Ser Asn Ile Ser Ser Leu 
    130                 135                 140                 


Thr Val Leu Pro Ser Ser His Cys Thr Asp Pro Tyr Phe Thr Pro Ile 
145                 150                 155                 160 


Pro Val Leu Gln Ala Asp Ala His Lys Gly Ile Leu Ser Met Ile Glu 
                165                 170                 175     


Arg Gly Leu Ile Pro Pro Thr Ala Arg Ile Thr Phe Gln Asn Pro Pro 
            180                 185                 190         


Ile Thr Pro Arg Ala Ala Pro Leu His Ser Phe Asp Glu Ala Arg Lys 
        195                 200                 205             


Ile Pro Thr Val Ala Thr Phe Thr Ile Pro Arg Glu Pro Pro Pro Ser 
    210                 215                 220                 


Pro Ala Glu Val Lys Phe Phe Pro Lys Lys Gln Arg Ser Lys Gly Lys 
225                 230                 235                 240 


Ser Arg Arg Ser Arg Gly His His Asp Arg Lys Ala Met Lys Val Lys 
                245                 250                 255     


Thr Pro Leu Arg Ala Leu Lys Ser Leu Trp Asp Tyr Asp Phe Leu Ile 
            260                 265                 270         


Tyr Asp Gly Val Ile Asp Asn Thr Ala Pro Asp Phe Leu Ala Phe Lys 
        275                 280                 285             


Glu His Phe Ser Leu Ala Trp Gly Gly Ile Phe Ser Leu Leu Glu His 
    290                 295                 300                 


Val Glu Lys Phe Leu Arg Asn Tyr Ala Ile Pro Glu Val Lys Ile Lys 
305                 310                 315                 320 


Gly Asn Asn Leu Val Ala Leu Leu Pro Glu Phe Glu Leu Thr Asn Lys 
                325                 330                 335     


Leu Thr Arg Tyr Asp Leu Leu Ser Val Leu Glu Asp Pro Ala His Val 
            340                 345                 350         


Gln Met Leu Ile Asn Leu Pro Gly Gln Arg Tyr Lys Gly Gln Asp Gly 
        355                 360                 365             


Asn Ser Glu Ala Ala Met Lys Ile Gln Ala Thr Trp Lys Cys Tyr Lys 
    370                 375                 380                 


Ala Arg Lys Phe Phe Leu Phe Tyr Arg Gln Gln Lys Trp Ala Ser Gly 
385                 390                 395                 400 


Val Ile Ala Ile Ala Trp Leu Leu Tyr Cys His Lys Thr Arg Leu Lys 
                405                 410                 415     


Lys Ile Leu Lys Glu Ser Arg Gln Arg His Leu Glu Asn Phe Arg Ile 
            420                 425                 430         


Arg Ala Lys His Leu Ala Ala Asn Trp Asn Arg Ile Arg Thr Ser Arg 
        435                 440                 445             


Arg Thr Ile Ile His Ile Pro Ser Leu Gly Tyr Ser Gln Pro Val Arg 
    450                 455                 460                 


Glu His Ile Ala Asp Phe Asn Thr Gln Gln Asn Met Gln Leu Gly Arg 
465                 470                 475                 480 


Leu Cys Asp Ile Leu Asp Ala Asn Val Asn Val Ile Tyr Ile Cys Ser 
                485                 490                 495     


His His Met Asn Asp Glu Leu Val Leu Tyr Tyr Lys Lys Ile Leu Ser 
            500                 505                 510         


Leu His Ala Ala Val Lys Ser Gly Asn Leu Glu Asp Arg Ser Asp Leu 
        515                 520                 525             


Gln Asp Arg Phe Lys Ile Ile Thr Pro Glu Ala Val Asn Ile Phe Pro 
    530                 535                 540                 


Lys His His Met Cys Leu Ala Thr His Leu Met Tyr Ser Pro Lys Ala 
545                 550                 555                 560 


Ile Lys Arg Ile Lys Asn Leu Ile Arg Gly Thr Glu Ala Tyr Ile Val 
                565                 570                 575     


Ser Gly Leu Leu His Arg Asp Asp Leu Ala Val Ala Asp Met Leu Asp 
            580                 585                 590         


Ile Pro Ile Leu Gly Ser Glu Pro Glu Leu Ala His Leu Tyr Ser Thr 
        595                 600                 605             


Lys Ser Gly Gly Lys Arg Val Phe Asp Ser Ala Asn Val Ala Val Pro 
    610                 615                 620                 


Pro Gly Ile Tyr Asp Ile Tyr Ser Gln Gln Gln Met Ile Glu Gln Leu 
625                 630                 635                 640 


Ser Gln Leu Ile Thr Asp His Leu Gln Ile Gln Arg Trp Leu Phe Lys 
                645                 650                 655     


Met Asp Ser Glu Phe Arg Gly Asn Gly Thr Ala Phe Cys Asp Ile Pro 
            660                 665                 670         


Ser Tyr Leu Lys Cys Tyr Lys Trp Val Leu Lys Glu Ser Ser Arg Tyr 
        675                 680                 685             


Gly Leu Glu Asp Trp Arg Lys Lys Trp Ala Gln Glu Pro Ala Leu Val 
    690                 695                 700                 


Lys Ile Ser Glu Glu Leu Ala Gly Ile Leu Ala Gln His Ala Gln Pro 
705                 710                 715                 720 


Val Asn Glu Lys Arg Phe Pro Thr Trp Arg Lys Phe Leu Gln Thr Phe 
                725                 730                 735     


Leu Ser Gln Gly Gly Val Ile Glu Ala Phe Pro Pro Ala Asp Asn Val 
            740                 745                 750         


Thr Asn Leu Thr Val Asp Met Leu Ile Glu Pro Asn Gly Lys Ile Ser 
        755                 760                 765             


Val Leu Ser Thr Gly Asp Gln Leu His Ala Glu Ser Pro Phe Ile Ser 
    770                 775                 780                 


Ser Gly Thr Thr Val Pro Gln Thr Ser Val Asp Pro Gln Val Leu Thr 
785                 790                 795                 800 


Tyr Leu Cys Leu Gln Ile Gly Lys Ala Cys Arg Met Arg Asp Val Val 
                805                 810                 815     


Gly Tyr Phe Ser Ile Asp Leu Val Thr Phe Ile Asp Pro Ser Thr Leu 
            820                 825                 830         


Glu Gln Gln Val Trp Ala Thr Gly Leu Asn Leu Ala Tyr Ser Asp Gln 
        835                 840                 845             


Leu Ala Leu Thr Gln Leu Thr Leu Tyr Leu Thr Asn Gly His Leu Asp 
    850                 855                 860                 


Cys Ser Leu Ser Thr Leu Glu Val Pro Arg Phe Val Pro Lys Glu Arg 
865                 870                 875                 880 


Lys Lys Thr Lys Cys Met Ser Ala Leu Ser Met Pro Met Leu Ala Thr 
                885                 890                 895     


Ser Arg Tyr Ala Val Met Thr Thr Gln Leu Arg His Ser Asn Leu Ser 
            900                 905                 910         


Leu Val Phe His Tyr Val Phe Leu Gln Ile Cys Arg Ala His Gly Ile 
        915                 920                 925             


Gly Tyr Asp Leu Glu Glu Arg Gln Gly Thr Val Phe Ile Leu Tyr Glu 
    930                 935                 940                 


His Leu Lys Arg His Lys Leu Gly Met Leu Thr Ile Gly Glu Asp Leu 
945                 950                 955                 960 


Gln Gly Val Leu Met Thr Phe Ala Arg His Leu Phe Ile Ile His Gln 
                965                 970                 975     


Glu Ile Ser Ala Pro Asn Met Gln Gly Glu Thr Asn Phe Lys Thr Thr 
            980                 985                 990         


Ile Ala Asp Ile Glu Thr Ile Leu  Arg Val Thr Lys Glu  Asn Lys Met 
        995                 1000                 1005             


Arg Phe  Glu Glu Glu Gln Gln  Ser Lys Asp Asp Lys  Asn Leu Ser 
    1010                 1015                 1020             


Lys Pro  Lys Lys 
    1025         


<210>  5557
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQCJ__Homo_sapiens__NP_001036170

<400>  5557

Met Arg Leu Glu Glu Leu Lys Arg Leu Gln Asn Pro Leu Glu Gln Val 
1               5                   10                  15      


Asn Asp Gly Lys Tyr Ser Phe Glu Asn His Gln Leu Ala Met Asp Ala 
            20                  25                  30          


Glu Asn Asn Ile Glu Lys Tyr Pro Leu Asn Leu Gln Pro Leu Glu Ser 
        35                  40                  45              


Lys Val Lys Ile Ile Gln Arg Ala Trp Arg Glu Tyr Leu Gln Arg Gln 
    50                  55                  60                  


Glu Pro Leu Gly Lys Arg Ser Pro Ser Pro Pro Ser Val Ser Ser Glu 
65                  70                  75                  80  


Lys Leu Ser Ser Ser Val Ser Met Asn Thr Phe Ser Asp Ser Ser Thr 
                85                  90                  95      


Pro Phe Ala Arg Ala Pro Val Gly Lys Ile His Pro Tyr Ile Ser Trp 
            100                 105                 110         


Arg Leu Gln Ser Pro Gly Asp Lys Leu Pro Gly Gly Arg Lys Val Ile 
        115                 120                 125             


Leu Leu Tyr Leu Asp Gln Leu Ala Arg Pro Thr Gly Phe Ile His Thr 
    130                 135                 140                 


Leu Lys Glu Pro Gln Ile Glu Arg Leu Gly Phe Leu Thr Leu Gln 
145                 150                 155                 


<210>  5558
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQCJ-SCHIP1__Homo_sapiens__NP_001184042

<400>  5558

Met Arg Leu Glu Glu Leu Lys Arg Leu Gln Asn Pro Leu Glu Gln Val 
1               5                   10                  15      


Asn Asp Gly Lys Tyr Ser Phe Glu Asn His Gln Leu Ala Met Asp Ala 
            20                  25                  30          


Glu Asn Asn Ile Glu Lys Tyr Pro Leu Asn Leu Gln Pro Leu Glu Ser 
        35                  40                  45              


Lys Val Lys Ile Ile Gln Arg Ala Trp Arg Glu Tyr Leu Gln Arg Gln 
    50                  55                  60                  


Glu Pro Leu Gly Lys Arg Ser Pro Ser Pro Pro Ser Val Ser Ser Glu 
65                  70                  75                  80  


Lys Leu Ser Ser Ser Val Ser Met Asn Thr Phe Ser Asp Ser Ser Thr 
                85                  90                  95      


Pro Asp Tyr Arg Glu Asp Gly Met Asp Leu Gly Ser Asp Ala Gly Ser 
            100                 105                 110         


Ser Ser Ser Ser Ser Arg Ala Ser Ser Gln Ser Asn Ser Thr Lys Val 
        115                 120                 125             


Thr Pro Cys Ser Glu Cys Lys Ser Ser Ser Ser Pro Gly Gly Ser Leu 
    130                 135                 140                 


Asp Leu Val Ser Ala Leu Glu Asp Tyr Glu Glu Pro Phe Pro Val Tyr 
145                 150                 155                 160 


Gln Lys Lys Val Ile Asp Glu Trp Ala Pro Glu Glu Asp Gly Glu Glu 
                165                 170                 175     


Glu Glu Glu Glu Asp Glu Arg Asp Gln Arg Gly Tyr Arg Asp Asp Arg 
            180                 185                 190         


Ser Pro Ala Arg Glu Pro Gly Asp Val Ser Ala Arg Thr Arg Ser Gly 
        195                 200                 205             


Gly Gly Gly Gly Arg Ser Ala Thr Thr Ala Met Pro Pro Pro Val Pro 
    210                 215                 220                 


Asn Gly Asn Leu His Gln His Asp Pro Gln Asp Leu Arg His Asn Gly 
225                 230                 235                 240 


Asn Val Val Val Ala Gly Arg Pro Ser Cys Ser Arg Gly Pro Arg Arg 
                245                 250                 255     


Ala Ile Gln Lys Pro Gln Pro Ala Gly Gly Arg Arg Ser Gly Arg Gly 
            260                 265                 270         


Pro Ala Ala Gly Gly Leu Cys Leu Gln Pro Pro Asp Gly Gly Thr Cys 
        275                 280                 285             


Val Pro Glu Glu Pro Pro Val Pro Pro Met Asp Trp Glu Ala Leu Glu 
    290                 295                 300                 


Lys His Leu Ala Gly Leu Gln Phe Arg Glu Gln Glu Val Arg Asn Gln 
305                 310                 315                 320 


Gly Gln Ala Arg Thr Asn Ser Thr Ser Ala Gln Lys Asn Glu Arg Glu 
                325                 330                 335     


Ser Ile Arg Gln Lys Leu Ala Leu Gly Ser Phe Phe Asp Asp Gly Pro 
            340                 345                 350         


Gly Ile Tyr Thr Ser Cys Ser Lys Ser Gly Lys Pro Ser Leu Ser Ser 
        355                 360                 365             


Arg Leu Gln Ser Gly Met Asn Leu Gln Ile Cys Phe Val Asn Asp Ser 
    370                 375                 380                 


Gly Ser Asp Lys Asp Ser Asp Ala Asp Asp Ser Lys Thr Glu Thr Ser 
385                 390                 395                 400 


Leu Asp Thr Pro Leu Ser Pro Met Ser Lys Gln Ser Ser Ser Tyr Ser 
                405                 410                 415     


Asp Arg Asp Thr Thr Glu Glu Glu Ser Glu Ser Leu Asp Asp Met Asp 
            420                 425                 430         


Phe Leu Thr Arg Gln Lys Lys Leu Gln Ala Glu Ala Lys Met Ala Leu 
        435                 440                 445             


Ala Met Ala Lys Pro Met Ala Lys Met Gln Val Glu Val Glu Lys Gln 
    450                 455                 460                 


Asn Arg Lys Lys Ser Pro Val Ala Asp Leu Leu Pro His Met Pro His 
465                 470                 475                 480 


Ile Ser Glu Cys Leu Met Lys Arg Ser Leu Lys Pro Thr Asp Leu Arg 
                485                 490                 495     


Asp Met Thr Ile Gly Gln Leu Gln Val Ile Val Asn Asp Leu His Ser 
            500                 505                 510         


Gln Ile Glu Ser Leu Asn Glu Glu Leu Val Gln Leu Leu Leu Ile Arg 
        515                 520                 525             


Asp Glu Leu His Thr Glu Gln Asp Ala Met Leu Val Asp Ile Glu Asp 
    530                 535                 540                 


Leu Thr Arg His Ala Glu Ser Gln Gln Lys His Met Ala Glu Lys Met 
545                 550                 555                 560 


Pro Ala Lys 
            


<210>  5559
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQCK__Homo_sapiens__NP_694940

<400>  5559

Met Ala Ala Pro Arg Gln Ile Pro Ser His Ile Val Arg Leu Lys Pro 
1               5                   10                  15      


Ser Cys Ser Thr Asp Ser Ser Phe Thr Arg Thr Pro Val Pro Thr Val 
            20                  25                  30          


Ser Leu Ala Ser Arg Glu Leu Pro Val Ser Ser Trp Gln Val Thr Glu 
        35                  40                  45              


Pro Ser Ser Lys Asn Leu Trp Glu Gln Ile Cys Lys Glu Tyr Glu Ala 
    50                  55                  60                  


Glu Gln Pro Pro Phe Pro Glu Gly Tyr Lys Val Lys Gln Glu Pro Val 
65                  70                  75                  80  


Ile Thr Val Ala Pro Val Glu Glu Met Leu Phe His Gly Phe Ser Ala 
                85                  90                  95      


Glu His Tyr Phe Pro Val Ser His Phe Thr Met Ile Ser Arg Thr Pro 
            100                 105                 110         


Cys Pro Gln Asp Lys Ser Glu Thr Ile Asn Pro Lys Thr Cys Ser Pro 
        115                 120                 125             


Lys Glu Tyr Leu Glu Thr Phe Ile Phe Pro Val Leu Leu Pro Gly Met 
    130                 135                 140                 


Ala Ser Leu Leu His Gln Ala Lys Lys Glu Lys Cys Phe Glu Arg Lys 
145                 150                 155                 160 


Arg Thr Lys Phe Ile Ala Cys Asp Phe Leu Thr Glu Trp Leu Tyr Asn 
                165                 170                 175     


Gln Asn Pro Lys Arg Ala Gly Glu Pro Phe Thr Glu Phe Phe Ser Ile 
            180                 185                 190         


Pro Phe Val Glu Glu Arg Leu Lys Gln His Pro Arg Pro Pro Ile Pro 
        195                 200                 205             


Leu Ser Leu Leu Leu Thr Glu Glu Glu Ala Ala Leu Tyr Ile Gln Ser 
    210                 215                 220                 


Phe Trp Arg Ala Cys Val Val Arg Cys Asp Pro Glu Ile Gln Glu Leu 
225                 230                 235                 240 


Arg Gln Trp Gln Lys Lys Leu Arg Glu Ala Lys His Ile His Gln Gln 
                245                 250                 255     


Val Lys Ile Phe Trp Ala Lys Gln Glu Gln Lys Val Lys Cys Lys Met 
            260                 265                 270         


Glu Asp Asp Ala Val Pro Ala Ala Lys Met Lys Ile Pro Ser Ser 
        275                 280                 285         


<210>  5560
<211>  1657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQGAP1__Homo_sapiens__NP_003861

<400>  5560

Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His 
1               5                   10                  15      


Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp 
            20                  25                  30          


Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu 
        35                  40                  45              


Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro 
    50                  55                  60                  


Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys 
65                  70                  75                  80  


Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr 
                85                  90                  95      


Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His 
            100                 105                 110         


Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu 
        115                 120                 125             


Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn 
    130                 135                 140                 


Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe 
145                 150                 155                 160 


Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp 
                165                 170                 175     


Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr 
            180                 185                 190         


Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn 
        195                 200                 205             


Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile 
    210                 215                 220                 


Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu 
225                 230                 235                 240 


Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser 
                245                 250                 255     


Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn 
            260                 265                 270         


Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu 
        275                 280                 285             


Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn 
    290                 295                 300                 


Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp 
305                 310                 315                 320 


Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg 
                325                 330                 335     


Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser 
            340                 345                 350         


Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys 
        355                 360                 365             


Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln 
    370                 375                 380                 


Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln 
385                 390                 395                 400 


Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala 
                405                 410                 415     


Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu 
            420                 425                 430         


Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro 
        435                 440                 445             


Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn 
    450                 455                 460                 


Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser 
465                 470                 475                 480 


Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg 
                485                 490                 495     


Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn 
            500                 505                 510         


Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val 
        515                 520                 525             


Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu 
    530                 535                 540                 


Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala 
545                 550                 555                 560 


Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala 
                565                 570                 575     


Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln 
            580                 585                 590         


Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly 
        595                 600                 605             


Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala 
    610                 615                 620                 


Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly 
625                 630                 635                 640 


Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val 
                645                 650                 655     


Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys 
            660                 665                 670         


Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His 
        675                 680                 685             


Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu 
    690                 695                 700                 


Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu 
705                 710                 715                 720 


Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr 
                725                 730                 735     


Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu 
            740                 745                 750         


Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg 
        755                 760                 765             


Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser 
    770                 775                 780                 


Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala 
785                 790                 795                 800 


Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala 
                805                 810                 815     


Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe 
            820                 825                 830         


Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala 
        835                 840                 845             


Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro 
    850                 855                 860                 


Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp 
865                 870                 875                 880 


Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val 
                885                 890                 895     


Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu 
            900                 905                 910         


Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln 
        915                 920                 925             


Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln 
    930                 935                 940                 


Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala 
945                 950                 955                 960 


Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe 
                965                 970                 975     


Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln 
            980                 985                 990         


Met Pro Gln Asn Lys Ser Thr Lys  Phe Met Asp Ser Val  Ile Phe Thr 
        995                 1000                 1005             


Leu Tyr  Asn Tyr Ala Ser Asn  Gln Arg Glu Glu Tyr  Leu Leu Leu 
    1010                 1015                 1020             


Arg Leu  Phe Lys Thr Ala Leu  Gln Glu Glu Ile Lys  Ser Lys Val 
    1025                 1030                 1035             


Asp Gln  Ile Gln Glu Ile Val  Thr Gly Asn Pro Thr  Val Ile Lys 
    1040                 1045                 1050             


Met Val  Val Ser Phe Asn Arg  Gly Ala Arg Gly Gln  Asn Ala Leu 
    1055                 1060                 1065             


Arg Gln  Ile Leu Ala Pro Val  Val Lys Glu Ile Met  Asp Asp Lys 
    1070                 1075                 1080             


Ser Leu  Asn Ile Lys Thr Asp  Pro Val Asp Ile Tyr  Lys Ser Trp 
    1085                 1090                 1095             


Val Asn  Gln Met Glu Ser Gln  Thr Gly Glu Ala Ser  Lys Leu Pro 
    1100                 1105                 1110             


Tyr Asp  Val Thr Pro Glu Gln  Ala Leu Ala His Glu  Glu Val Lys 
    1115                 1120                 1125             


Thr Arg  Leu Asp Ser Ser Ile  Arg Asn Met Arg Ala  Val Thr Asp 
    1130                 1135                 1140             


Lys Phe  Leu Ser Ala Ile Val  Ser Ser Val Asp Lys  Ile Pro Tyr 
    1145                 1150                 1155             


Gly Met  Arg Phe Ile Ala Lys  Val Leu Lys Asp Ser  Leu His Glu 
    1160                 1165                 1170             


Lys Phe  Pro Asp Ala Gly Glu  Asp Glu Leu Leu Lys  Ile Ile Gly 
    1175                 1180                 1185             


Asn Leu  Leu Tyr Tyr Arg Tyr  Met Asn Pro Ala Ile  Val Ala Pro 
    1190                 1195                 1200             


Asp Ala  Phe Asp Ile Ile Asp  Leu Ser Ala Gly Gly  Gln Leu Thr 
    1205                 1210                 1215             


Thr Asp  Gln Arg Arg Asn Leu  Gly Ser Ile Ala Lys  Met Leu Gln 
    1220                 1225                 1230             


His Ala  Ala Ser Asn Lys Met  Phe Leu Gly Asp Asn  Ala His Leu 
    1235                 1240                 1245             


Ser Ile  Ile Asn Glu Tyr Leu  Ser Gln Ser Tyr Gln  Lys Phe Arg 
    1250                 1255                 1260             


Arg Phe  Phe Gln Thr Ala Cys  Asp Val Pro Glu Leu  Gln Asp Lys 
    1265                 1270                 1275             


Phe Asn  Val Asp Glu Tyr Ser  Asp Leu Val Thr Leu  Thr Lys Pro 
    1280                 1285                 1290             


Val Ile  Tyr Ile Ser Ile Gly  Glu Ile Ile Asn Thr  His Thr Leu 
    1295                 1300                 1305             


Leu Leu  Asp His Gln Asp Ala  Ile Ala Pro Glu His  Asn Asp Pro 
    1310                 1315                 1320             


Ile His  Glu Leu Leu Asp Asp  Leu Gly Glu Val Pro  Thr Ile Glu 
    1325                 1330                 1335             


Ser Leu  Ile Gly Glu Ser Ser  Gly Asn Leu Asn Asp  Pro Asn Lys 
    1340                 1345                 1350             


Glu Ala  Leu Ala Lys Thr Glu  Val Ser Leu Thr Leu  Thr Asn Lys 
    1355                 1360                 1365             


Phe Asp  Val Pro Gly Asp Glu  Asn Ala Glu Met Asp  Ala Arg Thr 
    1370                 1375                 1380             


Ile Leu  Leu Asn Thr Lys Arg  Leu Ile Val Asp Val  Ile Arg Phe 
    1385                 1390                 1395             


Gln Pro  Gly Glu Thr Leu Thr  Glu Ile Leu Glu Thr  Pro Ala Thr 
    1400                 1405                 1410             


Ser Glu  Gln Glu Ala Glu His  Gln Arg Ala Met Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ile Arg  Asp Ala Lys Thr Pro  Asp Lys Met Lys Lys  Ser Lys Ser 
    1430                 1435                 1440             


Val Lys  Glu Asp Ser Asn Leu  Thr Leu Gln Glu Lys  Lys Glu Lys 
    1445                 1450                 1455             


Ile Gln  Thr Gly Leu Lys Lys  Leu Thr Glu Leu Gly  Thr Val Asp 
    1460                 1465                 1470             


Pro Lys  Asn Lys Tyr Gln Glu  Leu Ile Asn Asp Ile  Ala Arg Asp 
    1475                 1480                 1485             


Ile Arg  Asn Gln Arg Arg Tyr  Arg Gln Arg Arg Lys  Ala Glu Leu 
    1490                 1495                 1500             


Val Lys  Leu Gln Gln Thr Tyr  Ala Ala Leu Asn Ser  Lys Ala Thr 
    1505                 1510                 1515             


Phe Tyr  Gly Glu Gln Val Asp  Tyr Tyr Lys Ser Tyr  Ile Lys Thr 
    1520                 1525                 1530             


Cys Leu  Asp Asn Leu Ala Ser  Lys Gly Lys Val Ser  Lys Lys Pro 
    1535                 1540                 1545             


Arg Glu  Met Lys Gly Lys Lys  Ser Lys Lys Ile Ser  Leu Lys Tyr 
    1550                 1555                 1560             


Thr Ala  Ala Arg Leu His Glu  Lys Gly Val Leu Leu  Glu Ile Glu 
    1565                 1570                 1575             


Asp Leu  Gln Val Asn Gln Phe  Lys Asn Val Ile Phe  Glu Ile Ser 
    1580                 1585                 1590             


Pro Thr  Glu Glu Val Gly Asp  Phe Glu Val Lys Ala  Lys Phe Met 
    1595                 1600                 1605             


Gly Val  Gln Met Glu Thr Phe  Met Leu His Tyr Gln  Asp Leu Leu 
    1610                 1615                 1620             


Gln Leu  Gln Tyr Glu Gly Val  Ala Val Met Lys Leu  Phe Asp Arg 
    1625                 1630                 1635             


Ala Lys  Val Asn Val Asn Leu  Leu Ile Phe Leu Leu  Asn Lys Lys 
    1640                 1645                 1650             


Phe Tyr  Gly Lys 
    1655         


<210>  5561
<211>  1071
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQGAP2__Homo_sapiens__NP_001272390

<400>  5561

Met His Ser Leu Pro Gly Val Val Ala Val Gly Tyr Ile Asn Glu Ala 
1               5                   10                  15      


Ile Asp Glu Gly Asn Pro Leu Arg Thr Leu Glu Thr Leu Leu Leu Pro 
            20                  25                  30          


Thr Ala Asn Ile Ser Asp Val Asp Pro Ala His Ala Gln His Tyr Gln 
        35                  40                  45              


Asp Val Leu Tyr His Ala Lys Ser Gln Lys Leu Gly Asp Ser Glu Ser 
    50                  55                  60                  


Val Ser Lys Val Leu Trp Leu Asp Glu Ile Gln Gln Ala Val Asp Asp 
65                  70                  75                  80  


Ala Asn Val Asp Glu Asp Arg Ala Lys Gln Trp Val Thr Leu Val Val 
                85                  90                  95      


Asp Val Asn Gln Cys Leu Glu Gly Lys Lys Ser Ser Asp Ile Leu Ser 
            100                 105                 110         


Val Leu Lys Ser Ser Thr Ser Asn Ala Asn Asp Ile Ile Pro Glu Cys 
        115                 120                 125             


Ala Asp Lys Tyr Tyr Asp Ala Leu Val Lys Ala Lys Glu Leu Lys Ser 
    130                 135                 140                 


Glu Arg Val Ser Ser Asp Gly Ser Trp Leu Lys Leu Asn Leu His Lys 
145                 150                 155                 160 


Lys Tyr Asp Tyr Tyr Tyr Asn Thr Asp Ser Lys Glu Ser Ser Trp Val 
                165                 170                 175     


Thr Pro Glu Ser Cys Leu Tyr Lys Glu Ser Trp Leu Thr Gly Lys Glu 
            180                 185                 190         


Ile Glu Ala Phe Trp Lys Gly Tyr Lys Gln Arg Lys Glu Tyr Met His 
        195                 200                 205             


Arg Arg Gln Thr Phe Ile Asp Asn Thr Asp Ser Ile Val Lys Ile Gln 
    210                 215                 220                 


Ser Trp Phe Arg Met Ala Thr Ala Arg Lys Ser Tyr Leu Ser Arg Leu 
225                 230                 235                 240 


Gln Tyr Phe Arg Asp His Asn Asn Glu Ile Val Lys Ile Gln Ser Leu 
                245                 250                 255     


Leu Arg Ala Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Val Gly Ser 
            260                 265                 270         


Glu Asn Pro Pro Leu Thr Val Ile Arg Lys Phe Val Tyr Leu Leu Asp 
        275                 280                 285             


Gln Ser Asp Leu Asp Phe Gln Glu Glu Leu Glu Val Ala Arg Leu Arg 
    290                 295                 300                 


Glu Glu Val Val Thr Lys Ile Arg Ala Asn Gln Gln Leu Glu Lys Asp 
305                 310                 315                 320 


Leu Asn Leu Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Arg Ile 
                325                 330                 335     


Thr Leu Glu Asp Val Ile Ser His Ser Lys Lys Leu Asn Lys Lys Lys 
            340                 345                 350         


Gly Gly Glu Met Glu Ile Leu Asn Asn Thr Asp Asn Gln Gly Ile Lys 
        355                 360                 365             


Ser Leu Ser Lys Glu Arg Arg Lys Thr Leu Glu Thr Tyr Gln Gln Leu 
    370                 375                 380                 


Phe Tyr Leu Leu Gln Thr Asn Pro Leu Tyr Leu Ala Lys Leu Ile Phe 
385                 390                 395                 400 


Gln Met Pro Gln Asn Lys Ser Thr Lys Phe Met Asp Thr Val Ile Phe 
                405                 410                 415     


Thr Leu Tyr Asn Tyr Ala Ser Asn Gln Arg Glu Glu Tyr Leu Leu Leu 
            420                 425                 430         


Lys Leu Phe Lys Thr Ala Leu Glu Glu Glu Ile Lys Ser Lys Val Asp 
        435                 440                 445             


Gln Val Gln Asp Ile Val Thr Gly Asn Pro Thr Val Ile Lys Met Val 
    450                 455                 460                 


Val Ser Phe Asn Arg Gly Ala Arg Gly Gln Asn Thr Leu Arg Gln Leu 
465                 470                 475                 480 


Leu Ala Pro Val Val Lys Glu Ile Ile Asp Asp Lys Ser Leu Ile Ile 
                485                 490                 495     


Asn Thr Asn Pro Val Glu Val Tyr Lys Ala Trp Val Asn Gln Leu Glu 
            500                 505                 510         


Thr Gln Thr Gly Glu Ala Ser Lys Leu Pro Tyr Asp Val Thr Thr Glu 
        515                 520                 525             


Gln Ala Leu Thr Tyr Pro Glu Val Lys Asn Lys Leu Glu Ala Ser Ile 
    530                 535                 540                 


Glu Asn Leu Arg Arg Val Thr Asp Lys Val Leu Asn Ser Ile Ile Ser 
545                 550                 555                 560 


Ser Leu Asp Leu Leu Pro Tyr Gly Leu Arg Tyr Ile Ala Lys Val Leu 
                565                 570                 575     


Lys Asn Ser Ile His Glu Lys Phe Pro Asp Ala Thr Glu Asp Glu Leu 
            580                 585                 590         


Leu Lys Ile Val Gly Asn Leu Leu Tyr Tyr Arg Tyr Met Asn Pro Ala 
        595                 600                 605             


Ile Val Ala Pro Asp Gly Phe Asp Ile Ile Asp Met Thr Ala Gly Gly 
    610                 615                 620                 


Gln Ile Asn Ser Asp Gln Arg Arg Asn Leu Gly Ser Val Ala Lys Val 
625                 630                 635                 640 


Leu Gln His Ala Ala Ser Asn Lys Leu Phe Glu Gly Glu Asn Glu His 
                645                 650                 655     


Leu Ser Ser Met Asn Asn Tyr Leu Ser Glu Thr Tyr Gln Glu Phe Arg 
            660                 665                 670         


Lys Tyr Phe Lys Glu Ala Cys Asn Val Pro Glu Pro Glu Glu Lys Phe 
        675                 680                 685             


Asn Met Asp Lys Tyr Thr Asp Leu Val Thr Val Ser Lys Pro Val Ile 
    690                 695                 700                 


Tyr Ile Ser Ile Glu Glu Ile Ile Ser Thr His Ser Leu Leu Leu Glu 
705                 710                 715                 720 


His Gln Asp Ala Ile Ala Pro Glu Lys Asn Asp Leu Leu Ser Glu Leu 
                725                 730                 735     


Leu Gly Ser Leu Gly Glu Val Pro Thr Val Glu Ser Phe Leu Gly Glu 
            740                 745                 750         


Gly Ala Val Asp Pro Asn Asp Pro Asn Lys Ala Asn Thr Leu Ser Gln 
        755                 760                 765             


Leu Ser Lys Thr Glu Ile Ser Leu Val Leu Thr Ser Lys Tyr Asp Ile 
    770                 775                 780                 


Glu Asp Gly Glu Ala Ile Asp Ser Arg Ser Leu Met Ile Lys Thr Lys 
785                 790                 795                 800 


Lys Leu Ile Ile Asp Val Ile Arg Asn Gln Pro Gly Asn Thr Leu Thr 
                805                 810                 815     


Glu Ile Leu Glu Thr Pro Ala Thr Ala Gln Gln Glu Val Asp His Ala 
            820                 825                 830         


Thr Asp Met Val Ser Arg Ala Met Ile Asp Ser Arg Thr Pro Glu Glu 
        835                 840                 845             


Met Lys His Ser Gln Ser Met Ile Glu Asp Ala Gln Leu Pro Leu Glu 
    850                 855                 860                 


Gln Lys Lys Arg Lys Ile Gln Arg Asn Leu Arg Thr Leu Glu Gln Thr 
865                 870                 875                 880 


Gly His Val Ser Ser Glu Asn Lys Tyr Gln Asp Ile Leu Asn Glu Ile 
                885                 890                 895     


Ala Lys Asp Ile Arg Asn Gln Arg Ile Tyr Arg Lys Leu Arg Lys Ala 
            900                 905                 910         


Glu Leu Ala Lys Leu Gln Gln Thr Leu Asn Ala Leu Asn Lys Lys Ala 
        915                 920                 925             


Ala Phe Tyr Glu Glu Gln Ile Asn Tyr Tyr Asp Thr Tyr Ile Lys Thr 
    930                 935                 940                 


Cys Leu Asp Asn Leu Lys Arg Lys Asn Thr Arg Arg Ser Ile Lys Leu 
945                 950                 955                 960 


Asp Gly Lys Gly Glu Pro Lys Gly Ala Lys Arg Ala Lys Pro Val Lys 
                965                 970                 975     


Tyr Thr Ala Ala Lys Leu His Glu Lys Gly Val Leu Leu Asp Ile Asp 
            980                 985                 990         


Asp Leu Gln Thr Asn Gln Phe Lys  Asn Val Thr Phe Asp  Ile Ile Ala 
        995                 1000                 1005             


Thr Glu  Asp Val Gly Ile Phe  Asp Val Arg Ser Lys  Phe Leu Gly 
    1010                 1015                 1020             


Val Glu  Met Glu Lys Val Gln  Leu Asn Ile Gln Asp  Leu Leu Gln 
    1025                 1030                 1035             


Met Gln  Tyr Glu Gly Val Ala  Val Met Lys Met Phe  Asp Lys Val 
    1040                 1045                 1050             


Lys Val  Asn Val Asn Leu Leu  Ile Tyr Leu Leu Asn  Lys Lys Phe 
    1055                 1060                 1065             


Tyr Gly  Lys 
    1070     


<210>  5562
<211>  1631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQGAP3__Homo_sapiens__NP_839943

<400>  5562

Met Glu Arg Arg Ala Ala Gly Pro Gly Trp Ala Ala Tyr Glu Arg Leu 
1               5                   10                  15      


Thr Ala Glu Glu Met Asp Glu Gln Arg Arg Gln Asn Val Ala Tyr Gln 
            20                  25                  30          


Tyr Leu Cys Arg Leu Glu Glu Ala Lys Arg Trp Met Glu Ala Cys Leu 
        35                  40                  45              


Lys Glu Glu Leu Pro Ser Pro Val Glu Leu Glu Glu Ser Leu Arg Asn 
    50                  55                  60                  


Gly Val Leu Leu Ala Lys Leu Gly His Cys Phe Ala Pro Ser Val Val 
65                  70                  75                  80  


Pro Leu Lys Lys Ile Tyr Asp Val Glu Gln Leu Arg Tyr Gln Ala Thr 
                85                  90                  95      


Gly Leu His Phe Arg His Thr Asp Asn Ile Asn Phe Trp Leu Ser Ala 
            100                 105                 110         


Ile Ala His Ile Gly Leu Pro Ser Thr Phe Phe Pro Glu Thr Thr Asp 
        115                 120                 125             


Ile Tyr Asp Lys Lys Asn Met Pro Arg Val Val Tyr Cys Ile His Ala 
    130                 135                 140                 


Leu Ser Leu Phe Leu Phe Arg Leu Gly Leu Ala Pro Gln Ile His Asp 
145                 150                 155                 160 


Leu Tyr Gly Lys Val Lys Phe Thr Ala Glu Glu Leu Ser Asn Met Ala 
                165                 170                 175     


Ser Glu Leu Ala Lys Tyr Gly Leu Gln Leu Pro Ala Phe Ser Lys Ile 
            180                 185                 190         


Gly Gly Ile Leu Ala Asn Glu Leu Ser Val Asp Glu Ala Ala Val His 
        195                 200                 205             


Ala Ala Val Leu Ala Ile Asn Glu Ala Val Glu Arg Gly Val Val Glu 
    210                 215                 220                 


Asp Thr Leu Ala Ala Leu Gln Asn Pro Ser Ala Leu Leu Glu Asn Leu 
225                 230                 235                 240 


Arg Glu Pro Leu Ala Ala Val Tyr Gln Glu Met Leu Ala Gln Ala Lys 
                245                 250                 255     


Met Glu Lys Ala Ala Asn Ala Arg Asn His Asp Asp Arg Glu Ser Gln 
            260                 265                 270         


Asp Ile Tyr Asp His Tyr Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile 
        275                 280                 285             


Asn His Val Asn Val His Gly Ala Leu Glu Val Val Asp Asp Ala Leu 
    290                 295                 300                 


Glu Arg Gln Ser Pro Glu Ala Leu Leu Lys Ala Leu Gln Asp Pro Ala 
305                 310                 315                 320 


Leu Ala Leu Arg Gly Val Arg Arg Asp Phe Ala Asp Trp Tyr Leu Glu 
                325                 330                 335     


Gln Leu Asn Ser Asp Arg Glu Gln Lys Ala Gln Glu Leu Gly Leu Val 
            340                 345                 350         


Glu Leu Leu Glu Lys Glu Glu Val Gln Ala Gly Val Ala Ala Ala Asn 
        355                 360                 365             


Thr Lys Gly Asp Gln Glu Gln Ala Met Leu His Ala Val Gln Arg Ile 
    370                 375                 380                 


Asn Lys Ala Ile Arg Arg Gly Val Ala Ala Asp Thr Val Lys Glu Leu 
385                 390                 395                 400 


Met Cys Pro Glu Ala Gln Leu Pro Pro Val Tyr Pro Val Ala Ser Ser 
                405                 410                 415     


Met Tyr Gln Leu Glu Leu Ala Val Leu Gln Gln Gln Gln Gly Glu Leu 
            420                 425                 430         


Gly Gln Glu Glu Leu Phe Val Ala Val Glu Met Leu Ser Ala Val Val 
        435                 440                 445             


Leu Ile Asn Arg Ala Leu Glu Ala Arg Asp Ala Ser Gly Phe Trp Ser 
    450                 455                 460                 


Ser Leu Val Asn Pro Ala Thr Gly Leu Ala Glu Val Glu Gly Glu Asn 
465                 470                 475                 480 


Ala Gln Arg Tyr Phe Asp Ala Leu Leu Lys Leu Arg Gln Glu Arg Gly 
                485                 490                 495     


Met Gly Glu Asp Phe Leu Ser Trp Asn Asp Leu Gln Ala Thr Val Ser 
            500                 505                 510         


Gln Val Asn Ala Gln Thr Gln Glu Glu Thr Asp Arg Val Leu Ala Val 
        515                 520                 525             


Ser Leu Ile Asn Glu Ala Leu Asp Lys Gly Ser Pro Glu Lys Thr Leu 
    530                 535                 540                 


Ser Ala Leu Leu Leu Pro Ala Ala Gly Leu Asp Asp Val Ser Leu Pro 
545                 550                 555                 560 


Val Ala Pro Arg Tyr His Leu Leu Leu Val Ala Ala Lys Arg Gln Lys 
                565                 570                 575     


Ala Gln Val Thr Gly Asp Pro Gly Ala Val Leu Trp Leu Glu Glu Ile 
            580                 585                 590         


Arg Gln Gly Val Val Arg Ala Asn Gln Asp Thr Asn Thr Ala Gln Arg 
        595                 600                 605             


Met Ala Leu Gly Val Ala Ala Ile Asn Gln Ala Ile Lys Glu Gly Lys 
    610                 615                 620                 


Ala Ala Gln Thr Glu Arg Val Leu Arg Asn Pro Ala Val Ala Leu Arg 
625                 630                 635                 640 


Gly Val Val Pro Asp Cys Ala Asn Gly Tyr Gln Arg Ala Leu Glu Ser 
                645                 650                 655     


Ala Met Ala Lys Lys Gln Arg Pro Ala Asp Thr Ala Phe Trp Val Gln 
            660                 665                 670         


His Asp Met Lys Asp Gly Thr Ala Tyr Tyr Phe His Leu Gln Thr Phe 
        675                 680                 685             


Gln Gly Ile Trp Glu Gln Pro Pro Gly Cys Pro Leu Asn Thr Ser His 
    690                 695                 700                 


Leu Thr Arg Glu Glu Ile Gln Ser Ala Val Thr Lys Val Thr Ala Ala 
705                 710                 715                 720 


Tyr Asp Arg Gln Gln Leu Trp Lys Ala Asn Val Gly Phe Val Ile Gln 
                725                 730                 735     


Leu Gln Ala Arg Leu Arg Gly Phe Leu Val Arg Gln Lys Phe Ala Glu 
            740                 745                 750         


His Ser His Phe Leu Arg Thr Trp Leu Pro Ala Val Ile Lys Ile Gln 
        755                 760                 765             


Ala His Trp Arg Gly Tyr Arg Gln Arg Lys Ile Tyr Leu Glu Trp Leu 
    770                 775                 780                 


Gln Tyr Phe Lys Ala Asn Leu Asp Ala Ile Ile Lys Ile Gln Ala Trp 
785                 790                 795                 800 


Ala Arg Met Trp Ala Ala Arg Arg Gln Tyr Leu Arg Arg Leu His Tyr 
                805                 810                 815     


Phe Gln Lys Asn Val Asn Ser Ile Val Lys Ile Gln Ala Phe Phe Arg 
            820                 825                 830         


Ala Arg Lys Ala Gln Asp Asp Tyr Arg Ile Leu Val His Ala Pro His 
        835                 840                 845             


Pro Pro Leu Ser Val Val Arg Arg Phe Ala His Leu Leu Asn Gln Ser 
    850                 855                 860                 


Gln Gln Asp Phe Leu Ala Glu Ala Glu Leu Leu Lys Leu Gln Glu Glu 
865                 870                 875                 880 


Val Val Arg Lys Ile Arg Ser Asn Gln Gln Leu Glu Gln Asp Leu Asn 
                885                 890                 895     


Ile Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Arg Ile Thr Leu 
            900                 905                 910         


Gln Glu Val Val Ser His Cys Lys Lys Leu Thr Lys Arg Asn Lys Glu 
        915                 920                 925             


Gln Leu Ser Asp Met Met Val Leu Asp Lys Gln Lys Gly Leu Lys Ser 
    930                 935                 940                 


Leu Ser Lys Glu Lys Arg Gln Lys Leu Glu Ala Tyr Gln His Leu Phe 
945                 950                 955                 960 


Tyr Leu Leu Gln Thr Gln Pro Ile Tyr Leu Ala Lys Leu Ile Phe Gln 
                965                 970                 975     


Met Pro Gln Asn Lys Thr Thr Lys Phe Met Glu Ala Val Ile Phe Ser 
            980                 985                 990         


Leu Tyr Asn Tyr Ala Ser Ser Arg  Arg Glu Ala Tyr Leu  Leu Leu Gln 
        995                 1000                 1005             


Leu Phe  Lys Thr Ala Leu Gln  Glu Glu Ile Lys Ser  Lys Val Glu 
    1010                 1015                 1020             


Gln Pro  Gln Asp Val Val Thr  Gly Asn Pro Thr Val  Val Arg Leu 
    1025                 1030                 1035             


Val Val  Arg Phe Tyr Arg Asn  Gly Arg Gly Gln Ser  Ala Leu Gln 
    1040                 1045                 1050             


Glu Ile  Leu Gly Lys Val Ile  Gln Asp Val Leu Glu  Asp Lys Val 
    1055                 1060                 1065             


Leu Ser  Val His Thr Asp Pro  Val His Leu Tyr Lys  Asn Trp Ile 
    1070                 1075                 1080             


Asn Gln  Thr Glu Ala Gln Thr  Gly Gln Arg Ser His  Leu Pro Tyr 
    1085                 1090                 1095             


Asp Val  Thr Pro Glu Gln Ala  Leu Ser His Pro Glu  Val Gln Arg 
    1100                 1105                 1110             


Arg Leu  Asp Ile Ala Leu Arg  Asn Leu Leu Ala Met  Thr Asp Lys 
    1115                 1120                 1125             


Phe Leu  Leu Ala Ile Thr Ser  Ser Val Asp Gln Ile  Pro Tyr Gly 
    1130                 1135                 1140             


Met Arg  Tyr Val Ala Lys Val  Leu Lys Ala Thr Leu  Ala Glu Lys 
    1145                 1150                 1155             


Phe Pro  Asp Ala Thr Asp Ser  Glu Val Tyr Lys Val  Val Gly Asn 
    1160                 1165                 1170             


Leu Leu  Tyr Tyr Arg Phe Leu  Asn Pro Ala Val Val  Ala Pro Asp 
    1175                 1180                 1185             


Ala Phe  Asp Ile Val Ala Met  Ala Ala Gly Gly Ala  Leu Ala Ala 
    1190                 1195                 1200             


Pro Gln  Arg His Ala Leu Gly  Ala Val Ala Gln Leu  Leu Gln His 
    1205                 1210                 1215             


Ala Ala  Ala Gly Lys Ala Phe  Ser Gly Gln Ser Gln  His Leu Arg 
    1220                 1225                 1230             


Val Leu  Asn Asp Tyr Leu Glu  Glu Thr His Leu Lys  Phe Arg Lys 
    1235                 1240                 1245             


Phe Ile  His Arg Ala Cys Gln  Val Pro Glu Pro Glu  Glu Arg Phe 
    1250                 1255                 1260             


Ala Val  Asp Glu Tyr Ser Asp  Met Val Ala Val Ala  Lys Pro Met 
    1265                 1270                 1275             


Val Tyr  Ile Thr Val Gly Glu  Leu Val Asn Thr His  Arg Leu Leu 
    1280                 1285                 1290             


Leu Glu  His Gln Asp Cys Ile  Ala Pro Asp His Gln  Asp Pro Leu 
    1295                 1300                 1305             


His Glu  Leu Leu Glu Asp Leu  Gly Glu Leu Pro Thr  Ile Pro Asp 
    1310                 1315                 1320             


Leu Ile  Gly Glu Ser Ile Ala  Ala Asp Gly His Thr  Asp Leu Ser 
    1325                 1330                 1335             


Lys Leu  Glu Val Ser Leu Thr  Leu Thr Asn Lys Phe  Glu Gly Leu 
    1340                 1345                 1350             


Glu Ala  Asp Ala Asp Asp Ser  Asn Thr Arg Ser Leu  Leu Leu Ser 
    1355                 1360                 1365             


Thr Lys  Gln Leu Leu Ala Asp  Ile Ile Gln Phe His  Pro Gly Asp 
    1370                 1375                 1380             


Thr Leu  Lys Glu Ile Leu Ser  Leu Ser Ala Ser Arg  Glu Gln Glu 
    1385                 1390                 1395             


Ala Ala  His Lys Gln Leu Met  Ser Arg Arg Gln Ala  Cys Thr Ala 
    1400                 1405                 1410             


Gln Thr  Pro Glu Pro Leu Arg  Arg His Arg Ser Leu  Thr Ala His 
    1415                 1420                 1425             


Ser Leu  Leu Pro Leu Ala Glu  Lys Gln Arg Arg Val  Leu Arg Asn 
    1430                 1435                 1440             


Leu Arg  Arg Leu Glu Ala Leu  Gly Leu Val Ser Ala  Arg Asn Gly 
    1445                 1450                 1455             


Tyr Gln  Gly Leu Val Asp Glu  Leu Ala Lys Asp Ile  Arg Asn Gln 
    1460                 1465                 1470             


His Arg  His Arg His Arg Arg  Lys Ala Glu Leu Val  Lys Leu Gln 
    1475                 1480                 1485             


Ala Thr  Leu Gln Gly Leu Ser  Thr Lys Thr Thr Phe  Tyr Glu Glu 
    1490                 1495                 1500             


Gln Gly  Asp Tyr Tyr Ser Gln  Tyr Ile Arg Ala Cys  Leu Asp His 
    1505                 1510                 1515             


Leu Ala  Pro Asp Ser Lys Ser  Ser Gly Lys Gly Lys  Lys Gln Pro 
    1520                 1525                 1530             


Ser Leu  His Tyr Thr Ala Ala  Gln Leu Leu Glu Lys  Gly Val Leu 
    1535                 1540                 1545             


Val Glu  Ile Glu Asp Leu Pro  Ala Ser His Phe Arg  Asn Val Ile 
    1550                 1555                 1560             


Phe Asp  Ile Thr Pro Gly Asp  Glu Ala Gly Lys Phe  Glu Val Asn 
    1565                 1570                 1575             


Ala Lys  Phe Leu Gly Val Asp  Met Glu Arg Phe Gln  Leu His Tyr 
    1580                 1585                 1590             


Gln Asp  Leu Leu Gln Leu Gln  Tyr Glu Gly Val Ala  Val Met Lys 
    1595                 1600                 1605             


Leu Phe  Asn Lys Ala Lys Val  Asn Val Asn Leu Leu  Ile Phe Leu 
    1610                 1615                 1620             


Leu Asn  Lys Lys Phe Leu Arg  Lys 
    1625                 1630     


<210>  5563
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQSEC1__Homo_sapiens__NP_001127854

<400>  5563

Met Ala Cys Arg Arg Arg Tyr Phe Val Glu Gly Glu Ala Pro Ser Ser 
1               5                   10                  15      


Glu Thr Gly Thr Ser Leu Asp Ser Pro Ser Ala Tyr Pro Gln Gly Pro 
            20                  25                  30          


Leu Val Pro Gly Ser Ser Leu Ser Pro Asp His Tyr Glu His Thr Ser 
        35                  40                  45              


Val Gly Ala Tyr Gly Leu Tyr Ser Gly Pro Pro Gly Gln Gln Gln Arg 
    50                  55                  60                  


Thr Arg Arg Pro Lys Leu Gln His Ser Thr Ser Ile Leu Arg Lys Gln 
65                  70                  75                  80  


Ala Glu Glu Glu Ala Ile Lys Arg Ser Arg Ser Leu Ser Glu Ser Tyr 
                85                  90                  95      


Glu Leu Ser Ser Asp Leu Gln Asp Lys Gln Val Glu Met Leu Glu Arg 
            100                 105                 110         


Lys Tyr Gly Gly Arg Leu Val Thr Arg His Ala Ala Arg Thr Ile Gln 
        115                 120                 125             


Thr Ala Phe Arg Gln Tyr Gln Met Asn Lys Asn Phe Glu Arg Leu Arg 
    130                 135                 140                 


Ser Ser Met Ser Glu Asn Arg Met Ser Arg Arg Ile Val Leu Ser Asn 
145                 150                 155                 160 


Met Arg Met Gln Phe Ser Phe Glu Gly Pro Glu Lys Val His Ser Ser 
                165                 170                 175     


Tyr Phe Glu Gly Lys Gln Val Ser Val Thr Asn Asp Gly Ser Gln Leu 
            180                 185                 190         


Gly Ala Leu Val Ser Pro Glu Cys Gly Asp Leu Ser Glu Pro Thr Thr 
        195                 200                 205             


Leu Lys Ser Pro Ala Pro Ser Ser Asp Phe Ala Asp Ala Ile Thr Glu 
    210                 215                 220                 


Leu Glu Asp Ala Phe Ser Arg Gln Val Lys Ser Leu Ala Glu Ser Ile 
225                 230                 235                 240 


Asp Asp Ala Leu Asn Cys Arg Ser Leu His Thr Glu Glu Ala Pro Ala 
                245                 250                 255     


Leu Asp Ala Ala Arg Ala Arg Asp Thr Glu Pro Gln Thr Ala Leu His 
            260                 265                 270         


Gly Met Asp His Arg Lys Leu Asp Glu Met Thr Ala Ser Tyr Ser Asp 
        275                 280                 285             


Val Thr Leu Tyr Ile Asp Glu Glu Glu Leu Ser Pro Pro Leu Pro Leu 
    290                 295                 300                 


Ser Gln Ala Gly Asp Arg Pro Ser Ser Thr Glu Ser Asp Leu Arg Leu 
305                 310                 315                 320 


Arg Ala Gly Gly Ala Ala Pro Asp Tyr Trp Ala Leu Ala His Lys Glu 
                325                 330                 335     


Asp Lys Ala Asp Thr Asp Thr Ser Cys Arg Ser Thr Pro Ser Leu Glu 
            340                 345                 350         


Arg Gln Glu Gln Arg Leu Arg Val Glu His Leu Pro Leu Leu Thr Ile 
        355                 360                 365             


Glu Pro Pro Ser Asp Ser Ser Val Asp Leu Ser Asp Arg Ser Glu Arg 
    370                 375                 380                 


Gly Ser Leu Lys Arg Gln Ser Ala Tyr Glu Arg Ser Leu Gly Gly Gln 
385                 390                 395                 400 


Gln Gly Ser Pro Lys His Gly Pro His Ser Gly Ala Pro Lys Ser Leu 
                405                 410                 415     


Pro Arg Glu Glu Pro Glu Leu Arg Pro Arg Pro Pro Arg Pro Leu Asp 
            420                 425                 430         


Ser His Leu Ala Ile Asn Gly Ser Ala Asn Arg Gln Ser Lys Ser Glu 
        435                 440                 445             


Ser Asp Tyr Ser Asp Gly Asp Asn Asp Ser Ile Asn Ser Thr Ser Asn 
    450                 455                 460                 


Ser Asn Asp Thr Ile Asn Cys Ser Ser Glu Ser Ser Ser Arg Asp Ser 
465                 470                 475                 480 


Leu Arg Glu Gln Thr Leu Ser Lys Gln Thr Tyr His Lys Glu Ala Arg 
                485                 490                 495     


Asn Ser Trp Asp Ser Pro Ala Phe Ser Asn Asp Val Ile Arg Lys Arg 
            500                 505                 510         


His Tyr Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro Glu Lys Gly 
        515                 520                 525             


Val Gln Tyr Leu Ile Glu Arg Gly Phe Val Pro Asp Thr Pro Val Gly 
    530                 535                 540                 


Val Ala His Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile 
545                 550                 555                 560 


Gly Glu Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg Asp Val Leu 
                565                 570                 575     


Asp Cys Val Val Asp Glu Met Asp Phe Ser Thr Met Glu Leu Asp Glu 
            580                 585                 590         


Ala Leu Arg Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln 
        595                 600                 605             


Lys Val Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Ile Cys 
    610                 615                 620                 


Asn Pro Gly Val Val Arg Gln Phe Arg Asn Pro Asp Thr Ile Phe Ile 
625                 630                 635                 640 


Leu Ala Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn 
                645                 650                 655     


Val Lys Pro Glu Arg Lys Met Lys Leu Glu Asp Phe Ile Lys Asn Leu 
            660                 665                 670         


Arg Gly Val Asp Asp Gly Glu Asp Ile Pro Arg Glu Met Leu Met Gly 
        675                 680                 685             


Ile Tyr Glu Arg Ile Arg Lys Arg Glu Leu Lys Thr Asn Glu Asp His 
    690                 695                 700                 


Val Ser Gln Val Gln Lys Val Glu Lys Leu Ile Val Gly Lys Lys Pro 
705                 710                 715                 720 


Ile Gly Ser Leu His Pro Gly Leu Gly Cys Val Leu Ser Leu Pro His 
                725                 730                 735     


Arg Arg Leu Val Cys Tyr Cys Arg Leu Phe Glu Val Pro Asp Pro Asn 
            740                 745                 750         


Lys Pro Gln Lys Leu Gly Leu His Gln Arg Glu Ile Phe Leu Phe Asn 
        755                 760                 765             


Asp Leu Leu Val Val Thr Lys Ile Phe Gln Lys Lys Lys Asn Ser Val 
    770                 775                 780                 


Thr Tyr Ser Phe Arg Gln Ser Phe Ser Leu Tyr Gly Met Gln Val Leu 
785                 790                 795                 800 


Leu Phe Glu Asn Gln Tyr Tyr Pro Asn Gly Ile Arg Leu Thr Ser Ser 
                805                 810                 815     


Val Pro Gly Ala Asp Ile Lys Val Leu Ile Asn Phe Asn Ala Pro Asn 
            820                 825                 830         


Pro Gln Asp Arg Lys Lys Phe Thr Asp Asp Leu Arg Glu Ser Ile Ala 
        835                 840                 845             


Glu Val Gln Glu Met Glu Lys His Arg Ile Glu Ser Glu Leu Glu Lys 
    850                 855                 860                 


Gln Lys Gly Val Val Arg Pro Ser Met Ser Gln Cys Ser Ser Leu Lys 
865                 870                 875                 880 


Lys Glu Ser Gly Asn Gly Thr Leu Ser Arg Ala Cys Leu Asp Asp Ser 
                885                 890                 895     


Tyr Ala Ser Gly Glu Gly Leu Lys Arg Ser Ala Leu Ser Ser Ser Leu 
            900                 905                 910         


Arg Asp Leu Ser Glu Ala Gly Lys Arg Gly Arg Arg Ser Ser Ala Gly 
        915                 920                 925             


Ser Leu Glu Ser Asn Val Glu Gly Ser Ile Ile Ser Ser Pro His Met 
    930                 935                 940                 


Arg Arg Arg Ala Thr Ser Thr Arg Glu Cys Pro Ser Arg Pro His Gln 
945                 950                 955                 960 


Thr Met Pro Asn Ser Ser Ser Leu Leu Gly Ser Leu Phe Gly Ser Lys 
                965                 970                 975     


Arg Gly Lys Pro Pro Pro Gln Ala His Leu Pro Ser Ala Pro Ala Leu 
            980                 985                 990         


Pro Pro Pro His Pro Pro Val Val  Leu Pro His Leu Gln  His Ser Val 
        995                 1000                 1005             


Ala Gly  His His Leu Gly Pro  Pro Glu Gly Leu Pro  Gln Ala Ala 
    1010                 1015                 1020             


Met His  Gly His His Thr Gln  Tyr Cys His Met Gln  Asn Pro Pro 
    1025                 1030                 1035             


Pro Tyr  His His His His His  His His Pro Pro Gln  His Ile Gln 
    1040                 1045                 1050             


His Ala  His Gln Tyr His His  Gly Pro His Gly Gly  His Pro Ala 
    1055                 1060                 1065             


Tyr Gly  Ala His Ala His Gly  His Pro Pro Leu Pro  Ser Ala His 
    1070                 1075                 1080             


Val Gly  His Thr Val His His  His Gly Gln Pro Pro  Ala Pro Pro 
    1085                 1090                 1095             


Pro Pro  Thr Ser Ser Lys Ala  Lys Pro Ser Gly Ile  Ser Thr Ile 
    1100                 1105                 1110             


Val 
    


<210>  5564
<211>  1488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQSEC2__Homo_sapiens__NP_001104595

<400>  5564

Met Glu Ala Gly Ser Gly Pro Pro Gly Gly Pro Gly Ser Glu Ser Pro 
1               5                   10                  15      


Asn Arg Ala Val Glu Tyr Leu Leu Glu Leu Asn Asn Ile Ile Glu Ser 
            20                  25                  30          


Gln Gln Gln Leu Leu Glu Thr Gln Arg Arg Arg Ile Glu Glu Leu Glu 
        35                  40                  45              


Gly Gln Leu Asp Gln Leu Thr Gln Glu Asn Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Ser Gln Leu His Arg Gly Glu Leu His Arg Asp Pro His Gly Ala Arg 
65                  70                  75                  80  


Asp Ser Pro Gly Arg Glu Ser Gln Tyr Gln Asn Leu Arg Glu Thr Gln 
                85                  90                  95      


Phe His His Arg Glu Leu Arg Glu Ser Gln Phe His Gln Ala Ala Arg 
            100                 105                 110         


Asp Val Gly Tyr Pro Asn Arg Glu Gly Ala Tyr Gln Asn Arg Glu Ala 
        115                 120                 125             


Val Tyr Arg Asp Lys Glu Arg Asp Ala Ser Tyr Pro Leu Gln Asp Thr 
    130                 135                 140                 


Thr Gly Tyr Thr Ala Arg Glu Arg Asp Val Ala Gln Cys His Leu His 
145                 150                 155                 160 


His Glu Asn Pro Ala Leu Gly Arg Glu Arg Gly Gly Arg Glu Ala Gly 
                165                 170                 175     


Pro Ala His Pro Gly Arg Glu Lys Glu Ala Gly Tyr Ser Ala Ala Val 
            180                 185                 190         


Gly Val Gly Pro Arg Pro Pro Arg Glu Arg Gly Gln Leu Ser Arg Gly 
        195                 200                 205             


Ala Ser Arg Ser Ser Ser Pro Gly Ala Gly Gly Gly His Ser Thr Ser 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ala Thr Thr Leu Gln Arg Lys Ser Asp Gly Glu 
225                 230                 235                 240 


Asn Ser Arg Thr Val Ser Val Glu Gly Asp Ala Pro Gly Ser Asp Leu 
                245                 250                 255     


Ser Thr Ala Val Asp Ser Pro Gly Ser Gln Pro Pro Tyr Arg Leu Ser 
            260                 265                 270         


Gln Leu Pro Pro Ser Ser Ser His Met Gly Gly Pro Pro Ala Gly Val 
        275                 280                 285             


Gly Leu Pro Trp Ala Gln Arg Ala Arg Leu Gln Pro Ala Ser Val Ala 
    290                 295                 300                 


Leu Arg Lys Gln Glu Glu Glu Glu Ile Lys Arg Ser Lys Ala Leu Ser 
305                 310                 315                 320 


Asp Ser Tyr Glu Leu Ser Thr Asp Leu Gln Asp Lys Lys Val Glu Met 
                325                 330                 335     


Leu Glu Arg Lys Tyr Gly Gly Ser Phe Leu Ser Arg Arg Ala Ala Arg 
            340                 345                 350         


Thr Ile Gln Thr Ala Phe Arg Gln Tyr Arg Met Asn Lys Asn Phe Glu 
        355                 360                 365             


Arg Leu Arg Ser Ser Ala Ser Glu Ser Arg Met Ser Arg Arg Ile Ile 
    370                 375                 380                 


Leu Ser Asn Met Arg Met Gln Phe Ser Phe Glu Glu Tyr Glu Lys Ala 
385                 390                 395                 400 


Gln Asn Pro Ala Tyr Phe Glu Gly Lys Pro Ala Ser Leu Asp Glu Gly 
                405                 410                 415     


Ala Met Ala Gly Ala Arg Ser His Arg Leu Glu Arg Gly Leu Pro Tyr 
            420                 425                 430         


Gly Gly Ser Cys Gly Gly Gly Ile Asp Gly Gly Gly Ser Ser Val Thr 
        435                 440                 445             


Thr Ser Gly Glu Phe Ser Asn Asp Ile Thr Glu Leu Glu Asp Ser Phe 
    450                 455                 460                 


Ser Lys Gln Val Lys Ser Leu Ala Glu Ser Ile Asp Glu Ala Leu Asn 
465                 470                 475                 480 


Cys His Pro Ser Gly Pro Met Ser Glu Glu Pro Gly Ser Ala Gln Leu 
                485                 490                 495     


Glu Lys Arg Glu Ser Lys Glu Gln Gln Glu Asp Ser Ser Ala Thr Ser 
            500                 505                 510         


Phe Ser Asp Leu Pro Leu Tyr Leu Asp Asp Thr Val Pro Gln Gln Ser 
        515                 520                 525             


Pro Glu Arg Leu Pro Ser Thr Glu Pro Pro Pro Gln Gly Arg Pro Glu 
    530                 535                 540                 


Phe Trp Ala Pro Ala Pro Leu Pro Pro Val Pro Pro Pro Val Pro Ser 
545                 550                 555                 560 


Gly Thr Arg Glu Asp Gly Ser Arg Glu Glu Gly Thr Arg Arg Gly Pro 
                565                 570                 575     


Gly Cys Leu Glu Cys Arg Asp Phe Arg Leu Arg Ala Ala His Leu Pro 
            580                 585                 590         


Leu Leu Thr Ile Glu Pro Pro Ser Asp Ser Ser Val Asp Leu Ser Asp 
        595                 600                 605             


Arg Ser Asp Arg Gly Ser Val His Arg Gln Leu Val Tyr Glu Ala Asp 
    610                 615                 620                 


Gly Cys Ser Pro His Gly Thr Leu Lys His Lys Gly Pro Pro Gly Arg 
625                 630                 635                 640 


Ala Pro Ile Pro His Arg His Tyr Pro Ala Pro Glu Gly Pro Ala Pro 
                645                 650                 655     


Ala Pro Pro Gly Pro Leu Pro Pro Ala Pro Asn Ser Gly Thr Gly Pro 
            660                 665                 670         


Ser Gly Val Ala Gly Gly Arg Arg Leu Gly Lys Cys Glu Ala Ala Gly 
        675                 680                 685             


Glu Asn Ser Asp Gly Gly Asp Asn Glu Ser Leu Glu Ser Ser Ser Asn 
    690                 695                 700                 


Ser Asn Glu Thr Ile Asn Cys Ser Ser Gly Ser Ser Ser Arg Asp Ser 
705                 710                 715                 720 


Leu Arg Glu Pro Pro Ala Thr Gly Leu Cys Lys Gln Thr Tyr Gln Arg 
                725                 730                 735     


Glu Thr Arg His Ser Trp Asp Ser Pro Ala Phe Asn Asn Asp Val Val 
            740                 745                 750         


Gln Arg Arg His Tyr Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro 
        755                 760                 765             


Glu Lys Gly Ile Gln Tyr Leu Ile Glu Arg Gly Phe Leu Ser Asp Thr 
    770                 775                 780                 


Pro Val Gly Val Ala His Phe Ile Leu Glu Arg Lys Gly Leu Ser Arg 
785                 790                 795                 800 


Gln Met Ile Gly Glu Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg 
                805                 810                 815     


Asp Val Leu Asp Cys Val Val Asp Glu Met Asp Phe Ser Ser Met Asp 
            820                 825                 830         


Leu Asp Asp Ala Leu Arg Lys Phe Gln Ser His Ile Arg Val Gln Gly 
        835                 840                 845             


Glu Ala Gln Lys Val Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr 
    850                 855                 860                 


Cys Val Cys Asn Pro Ala Leu Val Arg Gln Phe Arg Asn Pro Asp Thr 
865                 870                 875                 880 


Ile Phe Ile Leu Ala Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr 
                885                 890                 895     


Ser Pro Ser Val Lys Ala Glu Arg Lys Met Lys Leu Asp Asp Phe Ile 
            900                 905                 910         


Lys Asn Leu Arg Gly Val Asp Asn Gly Glu Asp Ile Pro Arg Asp Leu 
        915                 920                 925             


Leu Val Gly Ile Tyr Gln Arg Ile Gln Gly Arg Glu Leu Arg Thr Asn 
    930                 935                 940                 


Asp Asp His Val Ser Gln Val Gln Ala Val Glu Arg Met Ile Val Gly 
945                 950                 955                 960 


Lys Lys Pro Val Leu Ser Leu Pro His Arg Arg Leu Val Cys Cys Cys 
                965                 970                 975     


Gln Leu Tyr Glu Val Pro Asp Pro Asn Arg Pro Gln Arg Leu Gly Leu 
            980                 985                 990         


His Gln Arg Glu Val Phe Leu Phe  Asn Asp Leu Leu Val  Val Thr Lys 
        995                 1000                 1005             


Ile Phe  Gln Lys Lys Lys Ile  Leu Val Thr Tyr Ser  Phe Arg Gln 
    1010                 1015                 1020             


Ser Phe  Pro Leu Val Glu Met  His Met Gln Leu Phe  Gln Asn Ser 
    1025                 1030                 1035             


Tyr Tyr  Gln Phe Gly Ile Lys  Leu Leu Ser Ala Val  Pro Gly Gly 
    1040                 1045                 1050             


Glu Arg  Lys Val Leu Ile Ile  Phe Asn Ala Pro Ser  Leu Gln Asp 
    1055                 1060                 1065             


Arg Leu  Arg Phe Thr Ser Asp  Leu Arg Glu Ser Ile  Ala Glu Val 
    1070                 1075                 1080             


Gln Glu  Met Glu Lys Tyr Arg  Val Glu Ser Glu Leu  Glu Lys Gln 
    1085                 1090                 1095             


Lys Gly  Met Met Arg Pro Asn  Ala Ser Gln Pro Gly  Gly Ala Lys 
    1100                 1105                 1110             


Asp Ser  Val Asn Gly Thr Met  Ala Arg Ser Ser Leu  Glu Asp Thr 
    1115                 1120                 1125             


Tyr Gly  Ala Gly Asp Gly Leu  Lys Arg Gly Ala Leu  Ser Ser Ser 
    1130                 1135                 1140             


Leu Arg  Asp Leu Ser Asp Ala  Gly Lys Arg Gly Arg  Arg Asn Ser 
    1145                 1150                 1155             


Val Gly  Ser Leu Asp Ser Thr  Ile Glu Gly Ser Val  Ile Ser Ser 
    1160                 1165                 1170             


Pro Arg  Pro His Gln Arg Met  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1175                 1180                 1185             


Pro Glu  Glu Tyr Lys Ser Gln  Arg Pro Val Ser Asn  Ser Ser Ser 
    1190                 1195                 1200             


Phe Leu  Gly Ser Leu Phe Gly  Ser Lys Arg Gly Lys  Gly Pro Phe 
    1205                 1210                 1215             


Gln Met  Pro Pro Pro Pro Thr  Gly Gln Ala Ser Ala  Ser Ser Ser 
    1220                 1225                 1230             


Ser Ala  Ser Ser Thr His His  His His His His His  His His Gly 
    1235                 1240                 1245             


His Ser  His Gly Gly Leu Gly  Val Leu Pro Asp Gly  Gln Ser Lys 
    1250                 1255                 1260             


Leu Gln  Ala Leu His Ala Gln  Tyr Cys Gln Gly Pro  Gly Pro Ala 
    1265                 1270                 1275             


Pro Pro  Pro Tyr Leu Pro Pro  Gln Gln Pro Ser Leu  Pro Pro Pro 
    1280                 1285                 1290             


Pro Gln  Gln Pro Pro Pro Leu  Pro Gln Leu Gly Ser  Ile Pro Pro 
    1295                 1300                 1305             


Pro Pro  Ala Ser Ala Pro Pro  Val Gly Pro His Arg  His Phe His 
    1310                 1315                 1320             


Ala His  Gly Pro Val Pro Gly  Pro Gln His Tyr Thr  Leu Gly Arg 
    1325                 1330                 1335             


Pro Gly  Arg Ala Pro Arg Arg  Gly Ala Gly Gly His  Pro Gln Phe 
    1340                 1345                 1350             


Ala Pro  His Gly Arg His Pro  Leu His Gln Pro Thr  Ser Pro Leu 
    1355                 1360                 1365             


Pro Leu  Tyr Ser Pro Ala Pro  Gln His Pro Pro Ala  His Lys Gln 
    1370                 1375                 1380             


Gly Pro  Lys His Phe Ile Phe  Ser His His Pro Gln  Met Met Pro 
    1385                 1390                 1395             


Ala Ala  Gly Ala Ala Gly Gly  Pro Gly Ser Arg Pro  Pro Gly Gly 
    1400                 1405                 1410             


Ser Tyr  Ser His Pro His His  Pro Gln Ser Pro Leu  Ser Pro His 
    1415                 1420                 1425             


Ser Pro  Ile Pro Pro His Pro  Ser Tyr Pro Pro Leu  Pro Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Thr Pro His Ser  Pro Leu Pro Pro Thr  Ser Pro His 
    1445                 1450                 1455             


Gly Pro  Leu His Ala Ser Gly  Pro Pro Gly Thr Ala  Asn Pro Pro 
    1460                 1465                 1470             


Ser Ala  Asn Pro Lys Ala Lys  Pro Ser Arg Ile Ser  Thr Val Val 
    1475                 1480                 1485             


<210>  5565
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IQSEC3__Homo_sapiens__NP_001164209

<400>  5565

Met Glu Ser Leu Leu Glu Asn Pro Val Arg Ala Val Leu Tyr Leu Lys 
1               5                   10                  15      


Glu Leu Thr Ala Ile Val Gln Asn Gln Gln Ser Leu Ile His Thr Gln 
            20                  25                  30          


Arg Glu Arg Ile Asp Glu Leu Glu Arg Arg Leu Asp Glu Leu Ser Ala 
        35                  40                  45              


Glu Asn Arg Ser Leu Trp Glu His Gln Gln Leu Leu Gln Ala Gln Pro 
    50                  55                  60                  


Pro Pro Gly Leu Val Pro Pro Ser Ser Ala Pro Leu Pro Ala Ala Pro 
65                  70                  75                  80  


Ala Thr Ala Pro Ala Ala Ala Ala Arg Ala Gln Glu Pro Leu Gln Asp 
                85                  90                  95      


Gln Gly Gln Arg Ser Ala Ala Ala Pro His Pro Ala Pro Asp Arg Pro 
            100                 105                 110         


Pro Arg Gln His His Gly Gln Leu Leu Glu Gln Pro Gln Arg Gly Pro 
        115                 120                 125             


Gly Ser Arg Ala His Thr Pro Gln Ser Pro His Lys His Leu Gly Thr 
    130                 135                 140                 


Gln Gly Ala Val Thr Asp Lys Glu Lys Glu Arg Pro Pro Ser Cys Cys 
145                 150                 155                 160 


Ala Ala Ala Gly Ala Leu Leu Gln His Lys Ser Pro Ser Ala Leu Gly 
                165                 170                 175     


Lys Gly Val Leu Ser Arg Arg Pro Glu Asn Glu Thr Val Leu His Gln 
            180                 185                 190         


Phe Cys Cys Pro Ala Ala Asp Ala Cys Ser Asp Leu Ala Ser Gln Ser 
        195                 200                 205             


Asp Gly Ser Cys Thr Gln Ala Gly Gly Gly Met Glu Asp Ser Val Val 
    210                 215                 220                 


Ala Ala Ala Ala Val Ala Ala Gly Arg Pro Ser Ala His Ala Pro Lys 
225                 230                 235                 240 


Ala Gln Ala Gln Glu Leu Gln Glu Glu Glu Glu Arg Pro Gly Ala Gly 
                245                 250                 255     


Ala Ala Ser Pro Arg Ala Gly Pro Gln His Lys Ala Ser Pro Gly Arg 
            260                 265                 270         


Gln Gln Pro Ala Leu Ala Thr Ala Leu Cys Pro His Ala Pro Ala Ala 
        275                 280                 285             


Ser Asp Tyr Glu Leu Ser Leu Asp Leu Lys Asn Lys Gln Ile Glu Met 
    290                 295                 300                 


Leu Glu His Lys Tyr Gly Gly His Leu Val Ser Arg Arg Ala Ala Cys 
305                 310                 315                 320 


Thr Ile Gln Thr Ala Phe Arg Gln Tyr Gln Leu Ser Lys Asn Phe Glu 
                325                 330                 335     


Lys Ile Arg Asn Ser Leu Leu Glu Ser Arg Leu Pro Arg Arg Ile Ser 
            340                 345                 350         


Leu Arg Lys Val Arg Ser Pro Thr Ala Glu Ser Leu Ala Ala Glu Lys 
        355                 360                 365             


Ala Leu Met Glu Gly Tyr Gly Leu Val Gly Leu Pro Leu Val Arg Ser 
    370                 375                 380                 


Pro Ser Leu Pro Pro Thr Phe Ala Gly Thr Leu Thr Glu Leu Glu Asp 
385                 390                 395                 400 


Ser Phe Thr Glu Gln Val Gln Ser Leu Ala Lys Ser Ile Asp Asp Ala 
                405                 410                 415     


Leu Ser Thr Trp Ser Leu Lys Thr Met Cys Ser Leu Arg Glu Ser Gly 
            420                 425                 430         


Ala Tyr Gln Leu His Gln Ala Leu Gln Ala Ala Ala Gly Pro Pro Gly 
        435                 440                 445             


Leu Glu Ala Glu Gly Arg Ala Pro Glu Ser Ala Gly Pro Gly Pro Gly 
    450                 455                 460                 


Asp Asp Ala Ala Glu Thr Pro Gly Leu Pro Pro Ala His Ser Gly Thr 
465                 470                 475                 480 


Leu Met Met Ala Phe Arg Asp Val Thr Val Gln Ile Ala Asn Gln Asn 
                485                 490                 495     


Ile Ser Val Ser Ser Ser Thr Ala Leu Ser Val Ala Asn Cys Leu Gly 
            500                 505                 510         


Ala Gln Thr Val Gln Ala Pro Ala Glu Pro Ala Ala Gly Lys Ala Glu 
        515                 520                 525             


Gln Gly Glu Thr Ser Gly Arg Glu Ala Pro Glu Ala Pro Ala Val Gly 
    530                 535                 540                 


Arg Glu Asp Ala Ser Ala Glu Asp Ser Cys Ala Glu Ala Ala Ala Ser 
545                 550                 555                 560 


Gly Ala Ala Asp Gly Ala Thr Ala Pro Lys Thr Glu Glu Glu Glu Glu 
                565                 570                 575     


Glu Glu Glu Thr Ala Glu Val Gly Arg Gly Ala Glu Ala Glu Ala Gly 
            580                 585                 590         


Asp Leu Glu Gln Leu Ser Ser Ser Ser Thr Ser Thr Lys Ser Ala Lys 
        595                 600                 605             


Ser Gly Ser Glu Ala Ser Ala Ser Ala Ser Lys Asp Ala Leu Gln Ala 
    610                 615                 620                 


Met Ile Leu Ser Leu Pro Arg Tyr His Cys Glu Asn Pro Ala Ser Cys 
625                 630                 635                 640 


Lys Ser Pro Thr Leu Ser Thr Asp Thr Leu Arg Lys Arg Leu Tyr Arg 
                645                 650                 655     


Ile Gly Leu Asn Leu Phe Asn Ile Asn Pro Asp Lys Gly Ile Gln Phe 
            660                 665                 670         


Leu Ile Ser Arg Gly Phe Ile Pro Asp Thr Pro Ile Gly Val Ala His 
        675                 680                 685             


Phe Leu Leu Gln Arg Lys Gly Leu Ser Arg Gln Met Ile Gly Glu Phe 
    690                 695                 700                 


Leu Gly Asn Ser Lys Lys Gln Phe Asn Arg Asp Val Leu Asp Cys Val 
705                 710                 715                 720 


Val Asp Glu Met Asp Phe Ser Ser Met Glu Leu Asp Glu Ala Leu Arg 
                725                 730                 735     


Lys Phe Gln Ala His Ile Arg Val Gln Gly Glu Ala Gln Lys Val Glu 
            740                 745                 750         


Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr Cys Met Cys Asn Pro Glu 
        755                 760                 765             


Val Val Gln Gln Phe His Asn Pro Asp Thr Ile Phe Ile Leu Ala Phe 
    770                 775                 780                 


Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr Ser Pro Asn Ile Lys Pro 
785                 790                 795                 800 


Asp Arg Lys Met Met Leu Glu Asp Phe Ile Arg Asn Leu Arg Gly Val 
                805                 810                 815     


Asp Asp Gly Ala Asp Ile Pro Arg Glu Leu Val Val Gly Ile Tyr Glu 
            820                 825                 830         


Arg Ile Gln Gln Lys Glu Leu Lys Ser Asn Glu Asp His Val Thr Tyr 
        835                 840                 845             


Val Thr Lys Val Glu Lys Ser Ile Val Gly Met Lys Thr Val Leu Ser 
    850                 855                 860                 


Val Pro His Arg Arg Leu Val Cys Cys Ser Arg Leu Phe Glu Val Thr 
865                 870                 875                 880 


Asp Val Asn Lys Leu Gln Lys Gln Ala Ala His Gln Arg Glu Val Phe 
                885                 890                 895     


Leu Phe Asn Asp Leu Leu Val Ile Leu Lys Leu Cys Pro Lys Lys Lys 
            900                 905                 910         


Ser Ser Ser Thr Tyr Thr Phe Cys Lys Ser Val Gly Leu Leu Gly Met 
        915                 920                 925             


Gln Phe Gln Leu Phe Glu Asn Glu Tyr Tyr Ser His Gly Ile Thr Leu 
    930                 935                 940                 


Val Thr Pro Leu Ser Gly Ser Glu Lys Lys Gln Val Leu His Phe Cys 
945                 950                 955                 960 


Ala Leu Gly Ser Asp Glu Met Gln Lys Phe Val Glu Asp Leu Lys Glu 
                965                 970                 975     


Ser Ile Ala Glu Val Thr Glu Leu Glu Gln Ile Arg Ile Glu Trp Glu 
            980                 985                 990         


Leu Glu Lys Gln Gln Gly Thr Lys  Thr Leu Ser Phe Lys  Pro Cys Gly 
        995                 1000                 1005             


Ala Gln  Gly Asp Pro Gln Ser  Lys Gln Gly Ser Pro  Thr Ala Lys 
    1010                 1015                 1020             


Arg Glu  Ala Ala Leu Arg Glu  Arg Pro Ala Glu Ser  Thr Val Glu 
    1025                 1030                 1035             


Val Ser  Ile His Asn Arg Leu  Gln Thr Ser Gln His  Asn Ser Gly 
    1040                 1045                 1050             


Leu Gly  Ala Glu Arg Gly Ala  Pro Val Pro Pro Pro  Asp Leu Gln 
    1055                 1060                 1065             


Pro Ser  Pro Pro Arg Gln Gln  Thr Pro Pro Leu Pro  Pro Pro Pro 
    1070                 1075                 1080             


Pro Thr  Pro Pro Gly Thr Leu  Val Gln Cys Gln Gln  Ile Val Lys 
    1085                 1090                 1095             


Val Ile  Val Leu Asp Lys Pro  Cys Leu Ala Arg Met  Glu Pro Leu 
    1100                 1105                 1110             


Leu Ser  Gln Ala Leu Ser Cys  Tyr Thr Ser Ser Ser  Ser Asp Ser 
    1115                 1120                 1125             


Cys Gly  Ser Thr Pro Leu Gly  Gly Pro Gly Ser Pro  Val Lys Val 
    1130                 1135                 1140             


Thr His  Gln Pro Pro Leu Pro  Pro Pro Pro Pro Pro  Tyr Asn His 
    1145                 1150                 1155             


Pro His  Gln Phe Cys Pro Pro  Gly Ser Leu Leu His  Gly His Arg 
    1160                 1165                 1170             


Tyr Ser  Ser Gly Ser Arg Ser  Leu Val 
    1175                 1180         


<210>  5566
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRAK1BP1__Homo_sapiens__NP_001010844

<400>  5566

Met Ser Leu Gln Lys Thr Pro Pro Thr Arg Val Phe Val Glu Leu Val 
1               5                   10                  15      


Pro Trp Ala Asp Arg Ser Arg Glu Asn Asn Leu Ala Ser Gly Arg Glu 
            20                  25                  30          


Thr Leu Pro Gly Leu Arg His Pro Leu Ser Ser Thr Gln Ala Gln Thr 
        35                  40                  45              


Ala Thr Arg Glu Val Gln Val Ser Gly Thr Ser Glu Val Ser Ala Gly 
    50                  55                  60                  


Pro Asp Arg Ala Gln Val Val Val Arg Val Ser Ser Thr Lys Glu Ala 
65                  70                  75                  80  


Ala Ala Glu Ala Lys Lys Ser Val Cys Arg Arg Leu Asp Tyr Ile Thr 
                85                  90                  95      


Gln Ser Leu Gln Gln Gln Gly Val Gln Ala Glu Asn Ile Thr Val Thr 
            100                 105                 110         


Lys Asp Phe Arg Arg Val Glu Asn Ala Tyr His Met Glu Ala Glu Val 
        115                 120                 125             


Cys Ile Thr Phe Thr Glu Phe Gly Lys Met Gln Asn Ile Cys Asn Phe 
    130                 135                 140                 


Leu Val Glu Lys Leu Asp Ser Ser Val Val Ile Ser Pro Pro Gln Phe 
145                 150                 155                 160 


Tyr His Thr Pro Gly Ser Val Glu Asn Leu Arg Arg Gln Ala Cys Leu 
                165                 170                 175     


Val Ala Val Glu Asn Ala Trp Arg Lys Ala Gln Glu Val Cys Asn Leu 
            180                 185                 190         


Val Gly Gln Thr Leu Gly Lys Pro Leu Leu Ile Lys Glu Glu Glu Thr 
        195                 200                 205             


Lys Glu Trp Glu Gly Gln Ile Asp Asp His Gln Ser Ser Arg Leu Ser 
    210                 215                 220                 


Ser Ser Leu Thr Val Gln Gln Lys Ile Lys Ser Ala Thr Ile His Ala 
225                 230                 235                 240 


Ala Ser Lys Val Phe Ile Thr Phe Glu Val Lys Gly Lys Glu Lys Arg 
                245                 250                 255     


Lys Lys His Leu 
            260 


<210>  5567
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRAK1__Homo_sapiens__NP_001020413

<400>  5567

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Glu Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala 
        515                 520                 525             


Ala Pro Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala 
    530                 535                 540                 


Ala Glu Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu 
545                 550                 555                 560 


Ser Leu Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro 
                565                 570                 575     


Ser Cys Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln 
            580                 585                 590         


Gly Asp Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg 
        595                 600                 605             


Pro Thr Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser 
    610                 615                 620                 


Ser Glu Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val 
625                 630                 635                 640 


Gln Lys Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu 
                645                 650                 655     


Leu Ser Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln 
            660                 665                 670         


Gly Pro Glu Glu Ser Asp Glu Phe Gln Ser 
        675                 680         


<210>  5568
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRAK2__Homo_sapiens__NP_001561

<400>  5568

Met Ala Cys Tyr Ile Tyr Gln Leu Pro Ser Trp Val Leu Asp Asp Leu 
1               5                   10                  15      


Cys Arg Asn Met Asp Ala Leu Ser Glu Trp Asp Trp Met Glu Phe Ala 
            20                  25                  30          


Ser Tyr Val Ile Thr Asp Leu Thr Gln Leu Arg Lys Ile Lys Ser Met 
        35                  40                  45              


Glu Arg Val Gln Gly Val Ser Ile Thr Arg Glu Leu Leu Trp Trp Trp 
    50                  55                  60                  


Gly Met Arg Gln Ala Thr Val Gln Gln Leu Val Asp Leu Leu Cys Arg 
65                  70                  75                  80  


Leu Glu Leu Tyr Arg Ala Ala Gln Ile Ile Leu Asn Trp Lys Pro Ala 
                85                  90                  95      


Pro Glu Ile Arg Cys Pro Ile Pro Ala Phe Pro Asp Ser Val Lys Pro 
            100                 105                 110         


Glu Lys Pro Leu Ala Ala Ser Val Arg Lys Ala Glu Asp Glu Gln Glu 
        115                 120                 125             


Glu Gly Gln Pro Val Arg Met Ala Thr Phe Pro Gly Pro Gly Ser Ser 
    130                 135                 140                 


Pro Ala Arg Ala His Gln Pro Ala Phe Leu Gln Pro Pro Glu Glu Asp 
145                 150                 155                 160 


Ala Pro His Ser Leu Arg Ser Asp Leu Pro Thr Ser Ser Asp Ser Lys 
                165                 170                 175     


Asp Phe Ser Thr Ser Ile Pro Lys Gln Glu Lys Leu Leu Ser Leu Ala 
            180                 185                 190         


Gly Asp Ser Leu Phe Trp Ser Glu Ala Asp Val Val Gln Ala Thr Asp 
        195                 200                 205             


Asp Phe Asn Gln Asn Arg Lys Ile Ser Gln Gly Thr Phe Ala Asp Val 
    210                 215                 220                 


Tyr Arg Gly His Arg His Gly Lys Pro Phe Val Phe Lys Lys Leu Arg 
225                 230                 235                 240 


Glu Thr Ala Cys Ser Ser Pro Gly Ser Ile Glu Arg Phe Phe Gln Ala 
                245                 250                 255     


Glu Leu Gln Ile Cys Leu Arg Cys Cys His Pro Asn Val Leu Pro Val 
            260                 265                 270         


Leu Gly Phe Cys Ala Ala Arg Gln Phe His Ser Phe Ile Tyr Pro Tyr 
        275                 280                 285             


Met Ala Asn Gly Ser Leu Gln Asp Arg Leu Gln Gly Gln Gly Gly Ser 
    290                 295                 300                 


Asp Pro Leu Pro Trp Pro Gln Arg Val Ser Ile Cys Ser Gly Leu Leu 
305                 310                 315                 320 


Cys Ala Val Glu Tyr Leu His Gly Leu Glu Ile Ile His Ser Asn Val 
                325                 330                 335     


Lys Ser Ser Asn Val Leu Leu Asp Gln Asn Leu Thr Pro Lys Leu Ala 
            340                 345                 350         


His Pro Met Ala His Leu Cys Pro Val Asn Lys Arg Ser Lys Tyr Thr 
        355                 360                 365             


Met Met Lys Thr His Leu Leu Arg Thr Ser Ala Ala Tyr Leu Pro Glu 
    370                 375                 380                 


Asp Phe Ile Arg Val Gly Gln Leu Thr Lys Arg Val Asp Ile Phe Ser 
385                 390                 395                 400 


Cys Gly Ile Val Leu Ala Glu Val Leu Thr Gly Ile Pro Ala Met Asp 
                405                 410                 415     


Asn Asn Arg Ser Pro Val Tyr Leu Lys Asp Leu Leu Leu Ser Asp Ile 
            420                 425                 430         


Pro Ser Ser Thr Ala Ser Leu Cys Ser Arg Lys Thr Gly Val Glu Asn 
        435                 440                 445             


Val Met Ala Lys Glu Ile Cys Gln Lys Tyr Leu Glu Lys Gly Ala Gly 
    450                 455                 460                 


Arg Leu Pro Glu Asp Cys Ala Glu Ala Leu Ala Thr Ala Ala Cys Leu 
465                 470                 475                 480 


Cys Leu Arg Arg Arg Asn Thr Ser Leu Gln Glu Val Cys Gly Ser Val 
                485                 490                 495     


Ala Ala Val Glu Glu Arg Leu Arg Gly Arg Glu Thr Leu Leu Pro Trp 
            500                 505                 510         


Ser Gly Leu Ser Glu Gly Thr Gly Ser Ser Ser Asn Thr Pro Glu Glu 
        515                 520                 525             


Thr Asp Asp Val Asp Asn Ser Ser Leu Asp Ala Ser Ser Ser Met Ser 
    530                 535                 540                 


Val Ala Pro Trp Ala Gly Ala Ala Thr Pro Leu Leu Pro Thr Glu Asn 
545                 550                 555                 560 


Gly Glu Gly Arg Leu Arg Val Ile Val Gly Arg Glu Ala Asp Ser Ser 
                565                 570                 575     


Ser Glu Ala Cys Val Gly Leu Glu Pro Pro Gln Asp Val Thr Glu Thr 
            580                 585                 590         


Ser Trp Gln Ile Glu Ile Asn Glu Ala Lys Arg Lys Leu Met Glu Asn 
        595                 600                 605             


Ile Leu Leu Tyr Lys Glu Glu Lys Val Asp Ser Ile Glu Leu Phe Gly 
    610                 615                 620                 


Pro 
625 


<210>  5569
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRAK3__Homo_sapiens__NP_001135995

<400>  5569

Met Ala Gly Asn Cys Gly Ala Arg Gly Ala Leu Ser Ala His Thr Leu 
1               5                   10                  15      


Leu Phe Asp Leu Pro Pro Ala Leu Leu Gly Glu Leu Cys Ala Val Leu 
            20                  25                  30          


Asp Ser Cys Asp Gly Ala Leu Gly Trp Arg Gly Leu Gly Ala Val Leu 
        35                  40                  45              


Ser Pro Ser Glu Lys Ser Tyr Gln Glu Gly Gly Phe Pro Asn Ile Leu 
    50                  55                  60                  


Phe Lys Glu Thr Ala Asn Val Thr Val Asp Asn Val Leu Ile Pro Glu 
65                  70                  75                  80  


His Asn Glu Lys Gly Ile Leu Leu Lys Ser Ser Ile Ser Phe Gln Asn 
                85                  90                  95      


Ile Ile Glu Gly Thr Arg Asn Phe His Lys Asp Phe Leu Ile Gly Glu 
            100                 105                 110         


Gly Glu Ile Phe Glu Val Tyr Arg Val Glu Ile Gln Asn Leu Thr Tyr 
        115                 120                 125             


Ala Val Lys Leu Phe Lys Gln Glu Lys Lys Met Gln Cys Lys Lys His 
    130                 135                 140                 


Trp Lys Arg Phe Leu Ser Glu Leu Glu Val Leu Leu Leu Phe His His 
145                 150                 155                 160 


Pro Asn Ile Leu Glu Leu Ala Ala Tyr Phe Thr Glu Thr Glu Lys Phe 
                165                 170                 175     


Cys Leu Ile Tyr Pro Tyr Met Arg Asn Gly Thr Leu Phe Asp Arg Leu 
            180                 185                 190         


Gln Cys Val Gly Asp Thr Ala Pro Leu Pro Trp His Ile Arg Ile Gly 
        195                 200                 205             


Ile Leu Ile Gly Ile Ser Lys Ala Ile His Tyr Leu His Asn Val Gln 
    210                 215                 220                 


Pro Cys Ser Val Ile Cys Gly Ser Ile Ser Ser Ala Asn Ile Leu Leu 
225                 230                 235                 240 


Asp Asp Gln Phe Gln Pro Lys Leu Thr Asp Phe Ala Met Ala His Phe 
                245                 250                 255     


Arg Ser His Leu Glu His Gln Ser Cys Thr Ile Asn Met Thr Ser Ser 
            260                 265                 270         


Ser Ser Lys His Leu Trp Tyr Met Pro Glu Glu Tyr Ile Arg Gln Gly 
        275                 280                 285             


Lys Leu Ser Ile Lys Thr Asp Val Tyr Ser Phe Gly Ile Val Ile Met 
    290                 295                 300                 


Glu Val Leu Thr Gly Cys Arg Val Val Leu Asp Asp Pro Lys His Ile 
305                 310                 315                 320 


Gln Leu Arg Asp Leu Leu Arg Glu Leu Met Glu Lys Arg Gly Leu Asp 
                325                 330                 335     


Ser Cys Leu Ser Phe Leu Asp Lys Lys Val Pro Pro Cys Pro Arg Asn 
            340                 345                 350         


Phe Ser Ala Lys Leu Phe Cys Leu Ala Gly Arg Cys Ala Ala Thr Arg 
        355                 360                 365             


Ala Lys Leu Arg Pro Ser Met Asp Glu Val Leu Asn Thr Leu Glu Ser 
    370                 375                 380                 


Thr Gln Ala Ser Leu Tyr Phe Ala Glu Asp Pro Pro Thr Ser Leu Lys 
385                 390                 395                 400 


Ser Phe Arg Cys Pro Ser Pro Leu Phe Leu Glu Asn Val Pro Ser Ile 
                405                 410                 415     


Pro Val Glu Asp Asp Glu Ser Gln Asn Asn Asn Leu Leu Pro Ser Asp 
            420                 425                 430         


Glu Gly Leu Arg Ile Asp Arg Met Thr Gln Lys Thr Pro Phe Glu Cys 
        435                 440                 445             


Ser Gln Ser Glu Val Met Phe Leu Ser Leu Asp Lys Lys Pro Glu Ser 
    450                 455                 460                 


Lys Arg Asn Glu Glu Ala Cys Asn Met Pro Ser Ser Ser Cys Glu Glu 
465                 470                 475                 480 


Ser Trp Phe Pro Lys Tyr Ile Val Pro Ser Gln Asp Leu Arg Pro Tyr 
                485                 490                 495     


Lys Val Asn Ile Asp Pro Ser Ser Glu Ala Pro Gly His Ser Cys Arg 
            500                 505                 510         


Ser Arg Pro Val Glu Ser Ser Cys Ser Ser Lys Phe Ser Trp Asp Glu 
        515                 520                 525             


Tyr Glu Gln Tyr Lys Lys Glu 
    530                 535 


<210>  5570
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRAK4__Homo_sapiens__NP_001138728

<400>  5570

Met Pro Phe Cys Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn 
1               5                   10                  15      


Leu Glu Gln Ser Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys 
            20                  25                  30          


Ser Leu Glu Val Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu 
        35                  40                  45              


Leu Lys Asn Val Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly 
    50                  55                  60                  


Gly Asn Lys Met Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr 
65                  70                  75                  80  


Val Asn Asn Thr Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp 
                85                  90                  95      


Ile Thr Thr Glu Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val 
            100                 105                 110         


Met Ala Lys Cys Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser 
        115                 120                 125             


Ser Asp Gly Asp Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly 
    130                 135                 140                 


Ser Leu Leu Asp Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser 
145                 150                 155                 160 


Trp His Met Arg Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn 
                165                 170                 175     


Phe Leu His Glu Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn 
            180                 185                 190         


Ile Leu Leu Asp Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu 
        195                 200                 205             


Ala Arg Ala Ser Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile 
    210                 215                 220                 


Val Gly Thr Thr Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile 
225                 230                 235                 240 


Thr Pro Lys Ser Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile 
                245                 250                 255     


Ile Thr Gly Leu Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu 
            260                 265                 270         


Leu Asp Ile Lys Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp 
        275                 280                 285             


Tyr Ile Asp Lys Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala 
    290                 295                 300                 


Met Tyr Ser Val Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg 
305                 310                 315                 320 


Pro Asp Ile Lys Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser 
                325                 330                 335     


<210>  5571
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IREB2__Homo_sapiens__NP_004127

<400>  5571

Met Asp Ala Pro Lys Ala Gly Tyr Ala Phe Glu Tyr Leu Ile Glu Thr 
1               5                   10                  15      


Leu Asn Asp Ser Ser His Lys Lys Phe Phe Asp Val Ser Lys Leu Gly 
            20                  25                  30          


Thr Lys Tyr Asp Val Leu Pro Tyr Ser Ile Arg Val Leu Leu Glu Ala 
        35                  40                  45              


Ala Val Arg Asn Cys Asp Gly Phe Leu Met Lys Lys Glu Asp Val Met 
    50                  55                  60                  


Asn Ile Leu Asp Trp Lys Thr Lys Gln Ser Asn Val Glu Val Pro Phe 
65                  70                  75                  80  


Phe Pro Ala Arg Val Leu Leu Gln Asp Phe Thr Gly Ile Pro Ala Met 
                85                  90                  95      


Val Asp Phe Ala Ala Met Arg Glu Ala Val Lys Thr Leu Gly Gly Asp 
            100                 105                 110         


Pro Glu Lys Val His Pro Ala Cys Pro Thr Asp Leu Thr Val Asp His 
        115                 120                 125             


Ser Leu Gln Ile Asp Phe Ser Lys Cys Ala Ile Gln Asn Ala Pro Asn 
    130                 135                 140                 


Pro Gly Gly Gly Asp Leu Gln Lys Ala Gly Lys Leu Ser Pro Leu Lys 
145                 150                 155                 160 


Val Gln Pro Lys Lys Leu Pro Cys Arg Gly Gln Thr Thr Cys Arg Gly 
                165                 170                 175     


Ser Cys Asp Ser Gly Glu Leu Gly Arg Asn Ser Gly Thr Phe Ser Ser 
            180                 185                 190         


Gln Ile Glu Asn Thr Pro Ile Leu Cys Pro Phe His Leu Gln Pro Val 
        195                 200                 205             


Pro Glu Pro Glu Thr Val Leu Lys Asn Gln Glu Val Glu Phe Gly Arg 
    210                 215                 220                 


Asn Arg Glu Arg Leu Gln Phe Phe Lys Trp Ser Ser Arg Val Phe Lys 
225                 230                 235                 240 


Asn Val Ala Val Ile Pro Pro Gly Thr Gly Met Ala His Gln Ile Asn 
                245                 250                 255     


Leu Glu Tyr Leu Ser Arg Val Val Phe Glu Glu Lys Asp Leu Leu Phe 
            260                 265                 270         


Pro Asp Ser Val Val Gly Thr Asp Ser His Ile Thr Met Val Asn Gly 
        275                 280                 285             


Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile Glu Thr Glu Ala Val 
    290                 295                 300                 


Met Leu Gly Leu Pro Val Ser Leu Thr Leu Pro Glu Val Val Gly Cys 
305                 310                 315                 320 


Glu Leu Thr Gly Ser Ser Asn Pro Phe Val Thr Ser Ile Asp Val Val 
                325                 330                 335     


Leu Gly Ile Thr Lys His Leu Arg Gln Val Gly Val Ala Gly Lys Phe 
            340                 345                 350         


Val Glu Phe Phe Gly Ser Gly Val Ser Gln Leu Ser Ile Val Asp Arg 
        355                 360                 365             


Thr Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly Ala Ile Leu Ser Phe 
    370                 375                 380                 


Phe Pro Val Asp Asn Val Thr Leu Lys His Leu Glu His Thr Gly Phe 
385                 390                 395                 400 


Ser Lys Ala Lys Leu Glu Ser Met Glu Thr Tyr Leu Lys Ala Val Lys 
                405                 410                 415     


Leu Phe Arg Asn Asp Gln Asn Ser Ser Gly Glu Pro Glu Tyr Ser Gln 
            420                 425                 430         


Val Ile Gln Ile Asn Leu Asn Ser Ile Val Pro Ser Val Ser Gly Pro 
        435                 440                 445             


Lys Arg Pro Gln Asp Arg Val Ala Val Thr Asp Met Lys Ser Asp Phe 
    450                 455                 460                 


Gln Ala Cys Leu Asn Glu Lys Val Gly Phe Lys Gly Phe Gln Ile Ala 
465                 470                 475                 480 


Ala Glu Lys Gln Lys Asp Ile Val Ser Ile His Tyr Glu Gly Ser Glu 
                485                 490                 495     


Tyr Lys Leu Ser His Gly Ser Val Val Ile Ala Ala Val Ile Ser Cys 
            500                 505                 510         


Thr Asn Asn Cys Asn Pro Ser Val Met Leu Ala Ala Gly Leu Leu Ala 
        515                 520                 525             


Lys Lys Ala Val Glu Ala Gly Leu Arg Val Lys Pro Tyr Ile Arg Thr 
    530                 535                 540                 


Ser Leu Ser Pro Gly Ser Gly Met Val Thr His Tyr Leu Ser Ser Ser 
545                 550                 555                 560 


Gly Val Leu Pro Tyr Leu Ser Lys Leu Gly Phe Glu Ile Val Gly Tyr 
                565                 570                 575     


Gly Cys Ser Thr Cys Val Gly Asn Thr Ala Pro Leu Ser Asp Ala Val 
            580                 585                 590         


Leu Asn Ala Val Lys Gln Gly Asp Leu Val Thr Cys Gly Ile Leu Ser 
        595                 600                 605             


Gly Asn Lys Asn Phe Glu Gly Arg Leu Cys Asp Cys Val Arg Ala Asn 
    610                 615                 620                 


Tyr Leu Ala Ser Pro Pro Leu Val Val Ala Tyr Ala Ile Ala Gly Thr 
625                 630                 635                 640 


Val Asn Ile Asp Phe Gln Thr Glu Pro Leu Gly Thr Asp Pro Thr Gly 
                645                 650                 655     


Lys Asn Ile Tyr Leu His Asp Ile Trp Pro Ser Arg Glu Glu Val His 
            660                 665                 670         


Arg Val Glu Glu Glu His Val Ile Leu Ser Met Phe Lys Ala Leu Lys 
        675                 680                 685             


Asp Lys Ile Glu Met Gly Asn Lys Arg Trp Asn Ser Leu Glu Ala Pro 
    690                 695                 700                 


Asp Ser Val Leu Phe Pro Trp Asp Leu Lys Ser Thr Tyr Ile Arg Cys 
705                 710                 715                 720 


Pro Ser Phe Phe Asp Lys Leu Thr Lys Glu Pro Ile Ala Leu Gln Ala 
                725                 730                 735     


Ile Glu Asn Ala His Val Leu Leu Tyr Leu Gly Asp Ser Val Thr Thr 
            740                 745                 750         


Asp His Ile Ser Pro Ala Gly Ser Ile Ala Arg Asn Ser Ala Ala Ala 
        755                 760                 765             


Lys Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg Glu Phe Asn Ser Tyr 
    770                 775                 780                 


Gly Ala Arg Arg Gly Asn Asp Ala Val Met Thr Arg Gly Thr Phe Ala 
785                 790                 795                 800 


Asn Ile Lys Leu Phe Asn Lys Phe Ile Gly Lys Pro Ala Pro Lys Thr 
                805                 810                 815     


Ile His Phe Pro Ser Gly Gln Thr Leu Asp Val Phe Glu Ala Ala Glu 
            820                 825                 830         


Leu Tyr Gln Lys Glu Gly Ile Pro Leu Ile Ile Leu Ala Gly Lys Lys 
        835                 840                 845             


Tyr Gly Ser Gly Asn Ser Arg Asp Trp Ala Ala Lys Gly Pro Tyr Leu 
    850                 855                 860                 


Leu Gly Val Lys Ala Val Leu Ala Glu Ser Tyr Glu Lys Ile His Lys 
865                 870                 875                 880 


Asp His Leu Ile Gly Ile Gly Ile Ala Pro Leu Gln Phe Leu Pro Gly 
                885                 890                 895     


Glu Asn Ala Asp Ser Leu Gly Leu Ser Gly Arg Glu Thr Phe Ser Leu 
            900                 905                 910         


Thr Phe Pro Glu Glu Leu Ser Pro Gly Ile Thr Leu Asn Ile Gln Thr 
        915                 920                 925             


Ser Thr Gly Lys Val Phe Ser Val Ile Ala Ser Phe Glu Asp Asp Val 
    930                 935                 940                 


Glu Ile Thr Leu Tyr Lys His Gly Gly Leu Leu Asn Phe Val Ala Arg 
945                 950                 955                 960 


Lys Phe Ser 
            


<210>  5572
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF1__Homo_sapiens__NP_002189

<400>  5572

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
            180                 185                 190         


Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp 
        195                 200                 205             


Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr 
    210                 215                 220                 


Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu 
225                 230                 235                 240 


Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr 
                245                 250                 255     


Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe 
            260                 265                 270         


Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly 
        275                 280                 285             


Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr 
    290                 295                 300                 


Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala 
305                 310                 315                 320 


Ile Pro Cys Ala Pro 
                325 


<210>  5573
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF2BP2__Homo_sapiens__NP_001070865

<400>  5573

Met Ala Ala Ala Val Ala Val Ala Ala Ala Ser Arg Arg Gln Ser Cys 
1               5                   10                  15      


Tyr Leu Cys Asp Leu Pro Arg Met Pro Trp Ala Met Ile Trp Asp Phe 
            20                  25                  30          


Thr Glu Pro Val Cys Arg Gly Cys Val Asn Tyr Glu Gly Ala Asp Arg 
        35                  40                  45              


Val Glu Phe Val Ile Glu Thr Ala Arg Gln Leu Lys Arg Ala His Gly 
    50                  55                  60                  


Cys Phe Pro Glu Gly Arg Ser Pro Pro Gly Ala Ala Ala Ser Ala Ala 
65                  70                  75                  80  


Ala Lys Pro Pro Pro Leu Ser Ala Lys Asp Ile Leu Leu Gln Gln Gln 
                85                  90                  95      


Gln Gln Leu Gly His Gly Gly Pro Glu Ala Ala Pro Arg Ala Pro Gln 
            100                 105                 110         


Ala Leu Glu Arg Tyr Pro Leu Ala Ala Ala Ala Glu Arg Pro Pro Arg 
        115                 120                 125             


Leu Gly Ser Asp Phe Gly Ser Ser Arg Pro Ala Ala Ser Leu Ala Gln 
    130                 135                 140                 


Pro Pro Thr Pro Gln Pro Pro Pro Val Asn Gly Ile Leu Val Pro Asn 
145                 150                 155                 160 


Gly Phe Ser Lys Leu Glu Glu Pro Pro Glu Leu Asn Arg Gln Ser Pro 
                165                 170                 175     


Asn Pro Arg Arg Gly His Ala Val Pro Pro Thr Leu Val Pro Leu Met 
            180                 185                 190         


Asn Gly Ser Ala Thr Pro Leu Pro Thr Ala Leu Gly Leu Gly Gly Arg 
        195                 200                 205             


Ala Ala Ala Ser Leu Ala Ala Val Ser Gly Thr Ala Ala Ala Ser Leu 
    210                 215                 220                 


Gly Ser Ala Gln Pro Thr Asp Leu Gly Ala His Lys Arg Pro Ala Ser 
225                 230                 235                 240 


Val Ser Ser Ser Ala Ala Val Glu His Glu Gln Arg Glu Ala Ala Ala 
                245                 250                 255     


Lys Glu Lys Gln Pro Pro Pro Pro Ala His Arg Gly Pro Ala Asp Ser 
            260                 265                 270         


Leu Ser Thr Ala Ala Gly Ala Ala Glu Leu Ser Ala Glu Gly Ala Gly 
        275                 280                 285             


Lys Ser Arg Gly Ser Gly Glu Gln Asp Trp Val Asn Arg Pro Lys Thr 
    290                 295                 300                 


Val Arg Asp Thr Leu Leu Ala Leu His Gln His Gly His Ser Gly Pro 
305                 310                 315                 320 


Phe Glu Ser Lys Phe Lys Lys Glu Pro Ala Leu Thr Ala Val Ala Arg 
                325                 330                 335     


Thr Ala Arg Lys Arg Lys Pro Ser Pro Glu Pro Glu Gly Glu Val Gly 
            340                 345                 350         


Pro Pro Lys Ile Asn Gly Glu Ala Gln Pro Trp Leu Ser Thr Ser Thr 
        355                 360                 365             


Glu Gly Leu Lys Ile Pro Met Thr Pro Thr Ser Ser Phe Val Ser Pro 
    370                 375                 380                 


Pro Pro Pro Thr Ala Ser Pro His Ser Asn Arg Thr Thr Pro Pro Glu 
385                 390                 395                 400 


Ala Ala Gln Asn Gly Gln Ser Pro Met Ala Ala Leu Ile Leu Val Ala 
                405                 410                 415     


Asp Asn Ala Gly Gly Ser His Ala Ser Lys Asp Ala Asn Gln Val His 
            420                 425                 430         


Ser Thr Thr Arg Arg Asn Ser Asn Ser Pro Pro Ser Pro Ser Ser Met 
        435                 440                 445             


Asn Gln Arg Arg Leu Gly Pro Arg Glu Val Gly Gly Gln Gly Ala Gly 
    450                 455                 460                 


Asn Thr Gly Gly Leu Glu Pro Val His Pro Ala Ser Leu Pro Asp Ser 
465                 470                 475                 480 


Ser Leu Ala Thr Ser Ala Pro Leu Cys Cys Thr Leu Cys His Glu Arg 
                485                 490                 495     


Leu Glu Asp Thr His Phe Val Gln Cys Pro Ser Val Pro Ser His Lys 
            500                 505                 510         


Phe Cys Phe Pro Cys Ser Arg Gln Ser Ile Lys Gln Gln Gly Ala Ser 
        515                 520                 525             


Gly Glu Val Tyr Cys Pro Ser Gly Glu Lys Cys Pro Leu Val Gly Ser 
    530                 535                 540                 


Asn Val Pro Trp Ala Phe Met Gln Gly Glu Ile Ala Thr Ile Leu Ala 
545                 550                 555                 560 


Gly Asp Val Lys Val Lys Lys Glu Arg Asp Ser 
                565                 570     


<210>  5574
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF2BPL__Homo_sapiens__NP_078772

<400>  5574

Met Ser Ala Ala Gln Val Ser Ser Ser Arg Arg Gln Ser Cys Tyr Leu 
1               5                   10                  15      


Cys Asp Leu Pro Arg Met Pro Trp Ala Met Ile Trp Asp Phe Ser Glu 
            20                  25                  30          


Pro Val Cys Arg Gly Cys Val Asn Tyr Glu Gly Ala Asp Arg Ile Glu 
        35                  40                  45              


Phe Val Ile Glu Thr Ala Arg Gln Leu Lys Arg Ala His Gly Cys Phe 
    50                  55                  60                  


Gln Asp Gly Arg Ser Pro Gly Pro Pro Pro Pro Val Gly Val Lys Thr 
65                  70                  75                  80  


Val Ala Leu Ser Ala Lys Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu 
        115                 120                 125             


Asn His Val Asp Gly Ser Ser Lys Pro Ala Val Leu Ala Ala Pro Ser 
    130                 135                 140                 


Gly Leu Glu Arg Tyr Gly Leu Ser Ala Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Val Glu Gln Arg Ser Arg Phe Glu Tyr Pro Pro Pro 
                165                 170                 175     


Pro Val Ser Leu Gly Ser Ser Ser His Thr Ala Arg Leu Pro Asn Gly 
            180                 185                 190         


Leu Gly Gly Pro Asn Gly Phe Pro Lys Pro Thr Pro Glu Glu Gly Pro 
        195                 200                 205             


Pro Glu Leu Asn Arg Gln Ser Pro Asn Ser Ser Ser Ala Ala Ala Ser 
    210                 215                 220                 


Val Ala Ser Arg Arg Gly Thr His Gly Gly Leu Val Thr Gly Leu Pro 
225                 230                 235                 240 


Asn Pro Gly Gly Gly Gly Gly Pro Gln Leu Thr Val Pro Pro Asn Leu 
                245                 250                 255     


Leu Pro Gln Thr Leu Leu Asn Gly Pro Ala Ser Ala Ala Val Leu Pro 
            260                 265                 270         


Pro Pro Pro Pro His Ala Leu Gly Ser Arg Gly Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Pro Gly Ala Pro Gly Gly Pro Ala Cys Leu Gly Gly Thr Pro Gly 
    290                 295                 300                 


Val Ser Ala Thr Ser Ser Ser Ala Ser Ser Ser Thr Ser Ser Ser Val 
305                 310                 315                 320 


Ala Glu Val Gly Val Gly Ala Gly Gly Lys Arg Pro Gly Ser Val Ser 
                325                 330                 335     


Ser Thr Asp Gln Glu Arg Glu Leu Lys Glu Lys Gln Arg Asn Ala Glu 
            340                 345                 350         


Ala Leu Ala Glu Leu Ser Glu Ser Leu Arg Asn Arg Ala Glu Glu Trp 
        355                 360                 365             


Ala Ser Lys Pro Lys Met Val Arg Asp Thr Leu Leu Thr Leu Ala Gly 
    370                 375                 380                 


Cys Thr Pro Tyr Glu Val Arg Phe Lys Lys Asp His Ser Leu Leu Gly 
385                 390                 395                 400 


Arg Val Phe Ala Phe Asp Ala Val Ser Lys Pro Gly Met Asp Tyr Glu 
                405                 410                 415     


Leu Lys Leu Phe Ile Glu Tyr Pro Thr Gly Ser Gly Asn Val Tyr Ser 
            420                 425                 430         


Ser Ala Ser Gly Val Ala Lys Gln Met Tyr Gln Asp Cys Met Lys Asp 
        435                 440                 445             


Phe Gly Arg Gly Leu Ser Ser Gly Phe Lys Tyr Leu Glu Tyr Glu Lys 
    450                 455                 460                 


Lys His Gly Ser Gly Asp Trp Arg Leu Leu Gly Asp Leu Leu Pro Glu 
465                 470                 475                 480 


Ala Val Arg Phe Phe Lys Glu Gly Val Pro Gly Ala Asp Met Leu Pro 
                485                 490                 495     


Gln Pro Tyr Leu Asp Ala Ser Cys Pro Met Leu Pro Thr Ala Leu Val 
            500                 505                 510         


Ser Leu Ser Arg Ala Pro Ser Ala Pro Pro Gly Thr Gly Ala Leu Pro 
        515                 520                 525             


Pro Ala Ala Pro Ser Gly Arg Gly Ala Ala Ala Ser Leu Arg Lys Arg 
    530                 535                 540                 


Lys Ala Ser Pro Glu Pro Pro Asp Ser Ala Glu Gly Ala Leu Lys Leu 
545                 550                 555                 560 


Gly Glu Glu Gln Gln Arg Gln Gln Trp Met Ala Asn Gln Ser Glu Ala 
                565                 570                 575     


Leu Lys Leu Thr Met Ser Ala Gly Gly Phe Ala Ala Pro Gly His Ala 
            580                 585                 590         


Ala Gly Gly Pro Pro Pro Pro Pro Pro Pro Leu Gly Pro His Ser Asn 
        595                 600                 605             


Arg Thr Thr Pro Pro Glu Ser Ala Pro Gln Asn Gly Pro Ser Pro Met 
    610                 615                 620                 


Ala Ala Leu Met Ser Val Ala Asp Thr Leu Gly Thr Ala His Ser Pro 
625                 630                 635                 640 


Lys Asp Gly Ser Ser Val His Ser Thr Thr Ala Ser Ala Arg Arg Asn 
                645                 650                 655     


Ser Ser Ser Pro Val Ser Pro Ala Ser Val Pro Gly Gln Arg Arg Leu 
            660                 665                 670         


Ala Ser Arg Asn Gly Asp Leu Asn Leu Gln Val Ala Pro Pro Pro Pro 
        675                 680                 685             


Ser Ala His Pro Gly Met Asp Gln Val His Pro Gln Asn Ile Pro Asp 
    690                 695                 700                 


Ser Pro Met Ala Asn Ser Gly Pro Leu Cys Cys Thr Ile Cys His Glu 
705                 710                 715                 720 


Arg Leu Glu Asp Thr His Phe Val Gln Cys Pro Ser Val Pro Ser His 
                725                 730                 735     


Lys Phe Cys Phe Pro Cys Ser Arg Glu Ser Ile Lys Ala Gln Gly Ala 
            740                 745                 750         


Thr Gly Glu Val Tyr Cys Pro Ser Gly Glu Lys Cys Pro Leu Val Gly 
        755                 760                 765             


Ser Asn Val Pro Trp Ala Phe Met Gln Gly Glu Ile Ala Thr Ile Leu 
    770                 775                 780                 


Ala Gly Asp Val Lys Val Lys Lys Glu Arg Asp Pro 
785                 790                 795     


<210>  5575
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF2__Homo_sapiens__NP_002190

<400>  5575

Met Pro Val Glu Arg Met Arg Met Arg Pro Trp Leu Glu Glu Gln Ile 
1               5                   10                  15      


Asn Ser Asn Thr Ile Pro Gly Leu Lys Trp Leu Asn Lys Glu Lys Lys 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Met His Ala Ala Arg His Gly Trp Asp Val 
        35                  40                  45              


Glu Lys Asp Ala Pro Leu Phe Arg Asn Trp Ala Ile His Thr Gly Lys 
    50                  55                  60                  


His Gln Pro Gly Val Asp Lys Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Lys Ser Ile Lys Lys Gly Asn Asn Ala Phe Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Leu Ser Glu Arg Pro Ser Lys Lys Gly Lys Lys Pro Lys Thr Glu 
        115                 120                 125             


Lys Glu Asp Lys Val Lys His Ile Lys Gln Glu Pro Val Glu Ser Ser 
    130                 135                 140                 


Leu Gly Leu Ser Asn Gly Val Ser Asp Leu Ser Pro Glu Tyr Ala Val 
145                 150                 155                 160 


Leu Thr Ser Thr Ile Lys Asn Glu Val Asp Ser Thr Val Asn Ile Ile 
                165                 170                 175     


Val Val Gly Gln Ser His Leu Asp Ser Asn Ile Glu Asn Gln Glu Ile 
            180                 185                 190         


Val Thr Asn Pro Pro Asp Ile Cys Gln Val Val Glu Val Thr Thr Glu 
        195                 200                 205             


Ser Asp Glu Gln Pro Val Ser Met Ser Glu Leu Tyr Pro Leu Gln Ile 
    210                 215                 220                 


Ser Pro Val Ser Ser Tyr Ala Glu Ser Glu Thr Thr Asp Ser Val Pro 
225                 230                 235                 240 


Ser Asp Glu Glu Ser Ala Glu Gly Arg Pro His Trp Arg Lys Arg Asn 
                245                 250                 255     


Ile Glu Gly Lys Gln Tyr Leu Ser Asn Met Gly Thr Arg Gly Ser Tyr 
            260                 265                 270         


Leu Leu Pro Gly Met Ala Ser Phe Val Thr Ser Asn Lys Pro Asp Leu 
        275                 280                 285             


Gln Val Thr Ile Lys Glu Glu Ser Asn Pro Val Pro Tyr Asn Ser Ser 
    290                 295                 300                 


Trp Pro Pro Phe Gln Asp Leu Pro Leu Ser Ser Ser Met Thr Pro Ala 
305                 310                 315                 320 


Ser Ser Ser Ser Arg Pro Asp Arg Glu Thr Arg Ala Ser Val Ile Lys 
                325                 330                 335     


Lys Thr Ser Asp Ile Thr Gln Ala Arg Val Lys Ser Cys 
            340                 345                 


<210>  5576
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF3__Homo_sapiens__NP_001184052

<400>  5576

Met Val Gly Arg Lys Gln Gly Trp Ser Cys Arg Val Thr Gly Ile Lys 
1               5                   10                  15      


Pro Gly Lys Pro Ala Trp Ala Glu Ala Thr Gly Ala Tyr Val Pro Gly 
            20                  25                  30          


Arg Asp Lys Pro Asp Leu Pro Thr Trp Lys Arg Asn Phe Arg Ser Ala 
        35                  40                  45              


Leu Asn Arg Lys Glu Gly Leu Arg Leu Ala Glu Asp Arg Ser Lys Asp 
    50                  55                  60                  


Pro His Asp Pro His Lys Ile Tyr Glu Phe Val Asn Ser Gly Val Gly 
65                  70                  75                  80  


Asp Phe Ser Gln Pro Asp Thr Ser Pro Asp Thr Asn Gly Gly Gly Ser 
                85                  90                  95      


Thr Ser Asp Thr Gln Glu Asp Ile Leu Asp Glu Leu Leu Gly Asn Met 
            100                 105                 110         


Val Leu Ala Pro Leu Pro Asp Pro Gly Pro Pro Ser Leu Ala Val Ala 
        115                 120                 125             


Pro Glu Pro Cys Pro Gln Pro Leu Arg Ser Pro Ser Leu Asp Asn Pro 
    130                 135                 140                 


Thr Pro Phe Pro Asn Leu Gly Pro Ser Glu Asn Pro Leu Lys Arg Leu 
145                 150                 155                 160 


Leu Val Pro Gly Glu Glu Trp Glu Phe Glu Val Thr Ala Phe Tyr Arg 
                165                 170                 175     


Gly Arg Gln Val Phe Gln Gln Thr Ile Ser Cys Pro Glu Gly Leu Arg 
            180                 185                 190         


Leu Val Gly Ser Glu Val Gly Asp Arg Thr Leu Pro Gly Trp Pro Val 
        195                 200                 205             


Thr Leu Pro Asp Pro Gly Met Ser Leu Thr Asp Arg Gly Val Met Ser 
    210                 215                 220                 


Tyr Val Arg His Val Leu Ser Cys Leu Gly Gly Gly Leu Ala Leu Trp 
225                 230                 235                 240 


Arg Ala Gly Gln Trp Leu Trp Ala Gln Arg Leu Gly His Cys His Thr 
                245                 250                 255     


Tyr Trp Ala Val Ser Glu Glu Leu Leu Pro Asn Ser Gly His Gly Pro 
            260                 265                 270         


Asp Gly Glu Val Pro Lys Asp Lys Glu Gly Gly Val Phe Asp Leu Gly 
        275                 280                 285             


Pro Phe Ile Val Asp Leu Ile Thr Phe Thr Glu Gly Ser Gly Arg Ser 
    290                 295                 300                 


Pro Arg Tyr Ala Leu Trp Phe Cys Val Gly Glu Ser Trp Pro Gln Asp 
305                 310                 315                 320 


Gln Pro Trp Thr Lys Arg Leu Val Met Val Lys Val Val Pro Thr Cys 
                325                 330                 335     


Leu Arg Ala Leu Val Glu Met Ala Arg Val Gly Gly Ala Ser Ser Leu 
            340                 345                 350         


Glu Asn Thr Val Asp Leu His Ile Ser Asn Ser His Pro Leu Ser Leu 
        355                 360                 365             


Thr Ser Asp Gln Tyr Lys Ala Tyr Leu Gln Asp Leu Val Glu Gly Met 
    370                 375                 380                 


Asp Phe Gln Gly Pro Gly Glu Ser 
385                 390         


<210>  5577
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF4__Homo_sapiens__NP_001182215

<400>  5577

Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala 
1               5                   10                  15      


Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile 
            20                  25                  30          


Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser 
        35                  40                  45              


Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg 
    50                  55                  60                  


Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys 
65                  70                  75                  80  


Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg 
                85                  90                  95      


Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu 
            100                 105                 110         


Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val 
        115                 120                 125             


Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro 
    130                 135                 140                 


Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser 
145                 150                 155                 160 


Leu Pro Ala Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg Ser 
                165                 170                 175     


Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr Gln 
            180                 185                 190         


Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro Ala 
        195                 200                 205             


Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala Pro 
    210                 215                 220                 


Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg Ser 
225                 230                 235                 240 


Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu Tyr 
                245                 250                 255     


Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu Gly 
            260                 265                 270         


Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp Gln 
        275                 280                 285             


Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile Glu 
    290                 295                 300                 


Lys Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala Pro 
305                 310                 315                 320 


Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp Asp 
                325                 330                 335     


Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg Asp 
            340                 345                 350         


Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu Gln 
        355                 360                 365             


Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr Leu 
    370                 375                 380                 


Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu Ile 
385                 390                 395                 400 


Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe Ala 
                405                 410                 415     


Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu His 
            420                 425                 430         


Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser Ile 
        435                 440                 445             


Gln Glu 
    450 


<210>  5578
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF5__Homo_sapiens__NP_001092097

<400>  5578

Met Asn Gln Ser Ile Pro Val Ala Pro Thr Pro Pro Arg Arg Val Arg 
1               5                   10                  15      


Leu Lys Pro Trp Leu Val Ala Gln Val Asn Ser Cys Gln Tyr Pro Gly 
            20                  25                  30          


Leu Gln Trp Val Asn Gly Glu Lys Lys Leu Phe Cys Ile Pro Trp Arg 
        35                  40                  45              


His Ala Thr Arg His Gly Pro Ser Gln Asp Gly Asp Asn Thr Ile Phe 
    50                  55                  60                  


Lys Ala Trp Ala Lys Glu Thr Gly Lys Tyr Thr Glu Gly Val Asp Glu 
65                  70                  75                  80  


Ala Asp Pro Ala Lys Trp Lys Ala Asn Leu Arg Cys Ala Leu Asn Lys 
                85                  90                  95      


Ser Arg Asp Phe Arg Leu Ile Tyr Asp Gly Pro Arg Asp Met Pro Pro 
            100                 105                 110         


Gln Pro Tyr Lys Ile Tyr Glu Val Cys Ser Asn Gly Pro Ala Pro Thr 
        115                 120                 125             


Asp Ser Gln Pro Pro Glu Asp Tyr Ser Phe Gly Ala Gly Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Glu Glu Leu Gln Arg Met Leu Pro Ser Leu Ser Leu Thr 
145                 150                 155                 160 


Glu Asp Val Lys Trp Pro Pro Thr Leu Gln Pro Pro Thr Leu Arg Pro 
                165                 170                 175     


Pro Thr Leu Gln Pro Pro Thr Leu Gln Pro Pro Val Val Leu Gly Pro 
            180                 185                 190         


Pro Ala Pro Asp Pro Ser Pro Leu Ala Pro Pro Pro Gly Asn Pro Ala 
        195                 200                 205             


Gly Phe Arg Glu Leu Leu Ser Glu Val Leu Glu Pro Gly Pro Leu Pro 
    210                 215                 220                 


Ala Ser Leu Pro Pro Ala Gly Glu Gln Leu Leu Pro Asp Leu Leu Ile 
225                 230                 235                 240 


Ser Pro His Met Leu Pro Leu Thr Asp Leu Glu Ile Lys Phe Gln Tyr 
                245                 250                 255     


Arg Gly Arg Pro Pro Arg Ala Leu Thr Ile Ser Asn Pro His Gly Cys 
            260                 265                 270         


Arg Leu Phe Tyr Ser Gln Leu Glu Ala Thr Gln Glu Gln Val Glu Leu 
        275                 280                 285             


Phe Gly Pro Ile Ser Leu Glu Gln Val Arg Phe Pro Ser Pro Glu Asp 
    290                 295                 300                 


Ile Pro Ser Asp Lys Gln Arg Phe Tyr Thr Asn Gln Leu Leu Asp Val 
305                 310                 315                 320 


Leu Asp Arg Gly Leu Ile Leu Gln Leu Gln Gly Gln Asp Leu Tyr Ala 
                325                 330                 335     


Ile Arg Leu Cys Gln Cys Lys Val Phe Trp Ser Gly Pro Cys Ala Ser 
            340                 345                 350         


Ala His Asp Ser Cys Pro Asn Pro Ile Gln Arg Glu Val Lys Thr Lys 
        355                 360                 365             


Leu Phe Ser Leu Glu His Phe Leu Asn Glu Leu Ile Leu Phe Gln Lys 
    370                 375                 380                 


Gly Gln Thr Asn Thr Pro Pro Pro Phe Glu Ile Phe Phe Cys Phe Gly 
385                 390                 395                 400 


Glu Glu Trp Pro Asp Arg Lys Pro Arg Glu Lys Lys Leu Ile Thr Val 
                405                 410                 415     


Gln Val Val Pro Val Ala Ala Arg Leu Leu Leu Glu Met Phe Ser Gly 
            420                 425                 430         


Glu Leu Ser Trp Ser Ala Asp Ser Ile Arg Leu Gln Ile Ser Asn Pro 
        435                 440                 445             


Asp Leu Lys Asp Arg Met Val Glu Gln Phe Lys Glu Leu His His Ile 
    450                 455                 460                 


Trp Gln Ser Gln Gln Arg Leu Gln Pro Val Ala Gln Ala Pro Pro Gly 
465                 470                 475                 480 


Ala Gly Leu Gly Val Gly Gln Gly Pro Trp Pro Met His Pro Ala Gly 
                485                 490                 495     


Met Gln 
        


<210>  5579
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF6__Homo_sapiens__NP_001193625

<400>  5579

Met Tyr Asp Gly Thr Lys Glu Val Pro Met Asn Pro Val Lys Ile Tyr 
1               5                   10                  15      


Gln Val Cys Asp Ile Pro Gln Pro Gln Gly Ser Ile Ile Asn Pro Gly 
            20                  25                  30          


Ser Thr Gly Ser Ala Pro Trp Asp Glu Lys Asp Asn Asp Val Asp Glu 
        35                  40                  45              


Glu Asp Glu Glu Asp Glu Leu Asp Gln Ser Gln His His Val Pro Ile 
    50                  55                  60                  


Gln Asp Thr Phe Pro Phe Leu Asn Ile Asn Gly Ser Pro Met Ala Pro 
65                  70                  75                  80  


Ala Ser Val Gly Asn Cys Ser Val Gly Asn Cys Ser Pro Glu Ala Val 
                85                  90                  95      


Trp Pro Lys Thr Glu Pro Leu Glu Met Glu Val Pro Gln Ala Pro Ile 
            100                 105                 110         


Gln Pro Phe Tyr Ser Ser Pro Glu Leu Trp Ile Ser Ser Leu Pro Met 
        115                 120                 125             


Thr Asp Leu Asp Ile Lys Phe Gln Tyr Arg Gly Lys Glu Tyr Gly Gln 
    130                 135                 140                 


Thr Met Thr Val Ser Asn Pro Gln Gly Cys Arg Leu Phe Tyr Gly Asp 
145                 150                 155                 160 


Leu Gly Pro Met Pro Asp Gln Glu Glu Leu Phe Gly Pro Val Ser Leu 
                165                 170                 175     


Glu Gln Val Lys Phe Pro Gly Pro Glu His Ile Thr Asn Glu Lys Gln 
            180                 185                 190         


Lys Leu Phe Thr Ser Lys Leu Leu Asp Val Met Asp Arg Gly Leu Ile 
        195                 200                 205             


Leu Glu Val Ser Gly His Ala Ile Tyr Ala Ile Arg Leu Cys Gln Cys 
    210                 215                 220                 


Lys Val Tyr Trp Ser Gly Pro Cys Ala Pro Ser Leu Val Ala Pro Asn 
225                 230                 235                 240 


Leu Ile Glu Arg Gln Lys Lys Val Lys Leu Phe Cys Leu Glu Thr Phe 
                245                 250                 255     


Leu Ser Asp Leu Ile Ala His Gln Lys Gly Gln Ile Glu Lys Gln Pro 
            260                 265                 270         


Pro Phe Glu Ile Tyr Leu Cys Phe Gly Glu Glu Trp Pro Asp Gly Lys 
        275                 280                 285             


Pro Leu Glu Arg Lys Leu Ile Leu Val Gln Val Ile Pro Val Val Ala 
    290                 295                 300                 


Arg Met Ile Tyr Glu Met Phe Ser Gly Asp Phe Thr Arg Ser Phe Asp 
305                 310                 315                 320 


Ser Gly Ser Val Arg Leu Gln Ile Ser Thr Pro Asp Ile Lys Asp Asn 
                325                 330                 335     


Ile Val Ala Gln Leu Lys Gln Leu Tyr Arg Ile Leu Gln Thr Gln Glu 
            340                 345                 350         


Ser Trp Gln Pro Met Gln Pro Thr Pro Ser Met Gln Leu Pro Pro Ala 
        355                 360                 365             


Leu Pro Pro Gln 
    370         


<210>  5580
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF7__Homo_sapiens__NP_001563

<400>  5580

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
1               5                   10                  15      


Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
            20                  25                  30          


Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
        35                  40                  45              


Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
    50                  55                  60                  


Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
65                  70                  75                  80  


Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                85                  90                  95      


Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
            100                 105                 110         


Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
        115                 120                 125             


Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
    130                 135                 140                 


Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
145                 150                 155                 160 


His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                165                 170                 175     


Gly Asp Lys Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
            180                 185                 190         


Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
        195                 200                 205             


Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
    210                 215                 220                 


Ala Gly Gly Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val 
225                 230                 235                 240 


Glu Thr Thr Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly 
                245                 250                 255     


Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser 
            260                 265                 270         


Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala 
        275                 280                 285             


Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val 
    290                 295                 300                 


Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala 
305                 310                 315                 320 


Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu 
                325                 330                 335     


Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His 
            340                 345                 350         


Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala 
        355                 360                 365             


Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro 
    370                 375                 380                 


Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys 
385                 390                 395                 400 


Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu 
                405                 410                 415     


Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu 
            420                 425                 430         


Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu 
        435                 440                 445             


Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly 
    450                 455                 460                 


Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu 
465                 470                 475                 480 


Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu 
                485                 490                 495     


Met Glu Leu Glu Gln Pro Ala 
            500             


<210>  5581
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF8__Homo_sapiens__NP_002154

<400>  5581

Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu 
1               5                   10                  15      


Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu 
            20                  25                  30          


Lys Ser Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr 
        35                  40                  45              


Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys 
    50                  55                  60                  


Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr 
65                  70                  75                  80  


Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr 
                85                  90                  95      


Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile 
            100                 105                 110         


Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Thr Ala Gly 
        115                 120                 125             


Cys Val Asn Glu Val Thr Glu Met Glu Cys Gly Arg Ser Glu Ile Asp 
    130                 135                 140                 


Glu Leu Ile Lys Glu Pro Ser Val Asp Asp Tyr Met Gly Met Ile Lys 
145                 150                 155                 160 


Arg Ser Pro Ser Pro Pro Glu Ala Cys Arg Ser Gln Leu Leu Pro Asp 
                165                 170                 175     


Trp Trp Ala Gln Gln Pro Ser Thr Gly Val Pro Leu Val Thr Gly Tyr 
            180                 185                 190         


Thr Thr Tyr Asp Ala His His Ser Ala Phe Ser Gln Met Val Ile Ser 
        195                 200                 205             


Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr Thr Thr Cys Pro 
    210                 215                 220                 


Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu Pro Gly Thr Lys 
225                 230                 235                 240 


Leu Tyr Gly Pro Glu Gly Leu Glu Leu Val Arg Phe Pro Pro Ala Asp 
                245                 250                 255     


Ala Ile Pro Ser Glu Arg Gln Arg Gln Val Thr Arg Lys Leu Phe Gly 
            260                 265                 270         


His Leu Glu Arg Gly Val Leu Leu His Ser Ser Arg Gln Gly Val Phe 
        275                 280                 285             


Val Lys Arg Leu Cys Gln Gly Arg Val Phe Cys Ser Gly Asn Ala Val 
    290                 295                 300                 


Val Cys Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp Glu Val Val Gln 
305                 310                 315                 320 


Val Phe Asp Thr Ser Gln Phe Phe Arg Glu Leu Gln Gln Phe Tyr Asn 
                325                 330                 335     


Ser Gln Gly Arg Leu Pro Asp Gly Arg Val Val Leu Cys Phe Gly Glu 
            340                 345                 350         


Glu Phe Pro Asp Met Ala Pro Leu Arg Ser Lys Leu Ile Leu Val Gln 
        355                 360                 365             


Ile Glu Gln Leu Tyr Val Arg Gln Leu Ala Glu Glu Ala Gly Lys Ser 
    370                 375                 380                 


Cys Gly Ala Gly Ser Val Met Gln Ala Pro Glu Glu Pro Pro Pro Asp 
385                 390                 395                 400 


Gln Val Phe Arg Met Phe Pro Asp Ile Cys Ala Ser His Gln Arg Ser 
                405                 410                 415     


Phe Phe Arg Glu Asn Gln Gln Ile Thr Val 
            420                 425     


<210>  5582
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRF9__Homo_sapiens__NP_006075

<400>  5582

Met Ala Ser Gly Arg Ala Arg Cys Thr Arg Lys Leu Arg Asn Trp Val 
1               5                   10                  15      


Val Glu Gln Val Glu Ser Gly Gln Phe Pro Gly Val Cys Trp Asp Asp 
            20                  25                  30          


Thr Ala Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln 
        35                  40                  45              


Asp Phe Arg Glu Asp Gln Asp Ala Ala Phe Phe Lys Ala Trp Ala Ile 
    50                  55                  60                  


Phe Lys Gly Lys Tyr Lys Glu Gly Asp Thr Gly Gly Pro Ala Val Trp 
65                  70                  75                  80  


Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser Ser Glu Phe Lys Glu 
                85                  90                  95      


Val Pro Glu Arg Gly Arg Met Asp Val Ala Glu Pro Tyr Lys Val Tyr 
            100                 105                 110         


Gln Leu Leu Pro Pro Gly Ile Val Ser Gly Gln Pro Gly Thr Gln Lys 
        115                 120                 125             


Val Pro Ser Lys Arg Gln His Ser Ser Val Ser Ser Glu Arg Lys Glu 
    130                 135                 140                 


Glu Glu Asp Ala Met Gln Asn Cys Thr Leu Ser Pro Ser Val Leu Gln 
145                 150                 155                 160 


Asp Ser Leu Asn Asn Glu Glu Glu Gly Ala Ser Gly Gly Ala Val His 
                165                 170                 175     


Ser Asp Ile Gly Ser Ser Ser Ser Ser Ser Ser Pro Glu Pro Gln Glu 
            180                 185                 190         


Val Thr Asp Thr Thr Glu Ala Pro Phe Gln Gly Asp Gln Arg Ser Leu 
        195                 200                 205             


Glu Phe Leu Leu Pro Pro Glu Pro Asp Tyr Ser Leu Leu Leu Thr Phe 
    210                 215                 220                 


Ile Tyr Asn Gly Arg Val Val Gly Glu Ala Gln Val Gln Ser Leu Asp 
225                 230                 235                 240 


Cys Arg Leu Val Ala Glu Pro Ser Gly Ser Glu Ser Ser Met Glu Gln 
                245                 250                 255     


Val Leu Phe Pro Lys Pro Gly Pro Leu Glu Pro Thr Gln Arg Leu Leu 
            260                 265                 270         


Ser Gln Leu Glu Arg Gly Ile Leu Val Ala Ser Asn Pro Arg Gly Leu 
        275                 280                 285             


Phe Val Gln Arg Leu Cys Pro Ile Pro Ile Ser Trp Asn Ala Pro Gln 
    290                 295                 300                 


Ala Pro Pro Gly Pro Gly Pro His Leu Leu Pro Ser Asn Glu Cys Val 
305                 310                 315                 320 


Glu Leu Phe Arg Thr Ala Tyr Phe Cys Arg Asp Leu Val Arg Tyr Phe 
                325                 330                 335     


Gln Gly Leu Gly Pro Pro Pro Lys Phe Gln Val Thr Leu Asn Phe Trp 
            340                 345                 350         


Glu Glu Ser His Gly Ser Ser His Thr Pro Gln Asn Leu Ile Thr Val 
        355                 360                 365             


Lys Met Glu Gln Ala Phe Ala Arg Tyr Leu Leu Glu Gln Thr Pro Glu 
    370                 375                 380                 


Gln Gln Ala Ala Ile Leu Ser Leu Val 
385                 390             


<210>  5583
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRG1__Homo_sapiens__NP_001245335

<400>  5583

Met Met Leu Lys Ser Ile Thr Glu Ser Phe Ala Thr Ala Ile His Gly 
1               5                   10                  15      


Leu Lys Val Gly His Leu Thr Asp Arg Val Ile Gln Arg Ser Lys Arg 
            20                  25                  30          


Met Ile Leu Asp Thr Leu Gly Ala Gly Phe Leu Gly Thr Thr Thr Glu 
        35                  40                  45              


Val Phe His Ile Ala Ser Gln Tyr Ser Lys Ile Tyr Ser Ser Asn Ile 
    50                  55                  60                  


Ser Ser Thr Val Trp Gly Gln Pro Asp Ile Arg Leu Pro Pro Thr Tyr 
65                  70                  75                  80  


Ala Ala Phe Val Asn Gly Val Ala Ile His Ser Met Asp Phe Asp Asp 
                85                  90                  95      


Thr Trp His Pro Ala Thr His Pro Ser Gly Ala Val Leu Pro Val Leu 
            100                 105                 110         


Thr Ala Leu Ala Glu Ala Leu Pro Arg Ser Pro Lys Phe Ser Gly Leu 
        115                 120                 125             


Asp Leu Leu Leu Ala Phe Asn Val Gly Ile Glu Val Gln Gly Arg Leu 
    130                 135                 140                 


Leu His Phe Ala Lys Glu Ala Asn Asp Met Pro Lys Arg Phe His Pro 
145                 150                 155                 160 


Pro Ser Val Val Gly Thr Leu Gly Ser Ala Ala Ala Ala Ser Lys Phe 
                165                 170                 175     


Leu Gly Leu Ser Ser Thr Lys Cys Arg Glu Ala Leu Ala Ile Ala Val 
            180                 185                 190         


Ser His Ala Gly Ala Pro Met Ala Asn Ala Ala Thr Gln Thr Lys Pro 
        195                 200                 205             


Leu His Ile Gly Asn Ala Ala Lys His Gly Ile Glu Ala Ala Phe Leu 
    210                 215                 220                 


Ala Met Leu Gly Leu Gln Gly Asn Lys Gln Val Leu Asp Leu Glu Ala 
225                 230                 235                 240 


Gly Phe Gly Ala Phe Tyr Ala Asn Tyr Ser Pro Lys Val Leu Pro Ser 
                245                 250                 255     


Ile Ala Ser Tyr Ser Trp Leu Leu Asp Gln Gln Asp Val Ala Phe Lys 
            260                 265                 270         


Arg Phe Pro Ala His Leu Ser Thr His Trp Val Ala Asp Ala Ala Ala 
        275                 280                 285             


Ser Val Arg Lys His Leu Val Ala Glu Arg Ala Leu Leu Pro Thr Asp 
    290                 295                 300                 


Tyr Ile Lys Arg Ile Val Leu Arg Ile Pro Asn Val Gln Tyr Val Asn 
305                 310                 315                 320 


Arg Pro Phe Pro Val Ser Glu His Glu Ala Arg His Ser Phe Gln Tyr 
                325                 330                 335     


Val Ala Cys Ala Met Leu Leu Asp Gly Gly Ile Thr Val Pro Ser Phe 
            340                 345                 350         


His Glu Cys Gln Ile Asn Arg Pro Gln Val Arg Glu Leu Leu Ser Lys 
        355                 360                 365             


Val Glu Leu Glu Tyr Pro Pro Asp Asn Leu Pro Ser Phe Asn Ile Leu 
    370                 375                 380                 


Tyr Cys Glu Ile Ser Val Thr Leu Lys Asp Gly Ala Thr Phe Thr Asp 
385                 390                 395                 400 


Arg Ser Asp Thr Phe Tyr Gly His Trp Arg Lys Pro Leu Ser Gln Glu 
                405                 410                 415     


Asp Leu Glu Glu Lys Phe Arg Ala Asn Ala Ser Lys Met Leu Ser Trp 
            420                 425                 430         


Asp Thr Val Glu Ser Leu Ile Lys Ile Val Lys Asn Leu Glu Asp Leu 
        435                 440                 445             


Glu Asp Cys Ser Val Leu Thr Thr Leu Leu Lys Gly Pro Ser Pro Pro 
    450                 455                 460                 


Glu Val Ala Ser Asn Ser Pro Ala Cys Asn Asn Ser Ile Thr Asn Leu 
465                 470                 475                 480 


Ser 
    


<210>  5584
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRGM__Homo_sapiens__NP_001139277

<400>  5584

Met Glu Ala Met Asn Val Glu Lys Ala Ser Ala Asp Gly Asn Leu Pro 
1               5                   10                  15      


Glu Val Ile Ser Asn Ile Lys Glu Thr Leu Lys Ile Val Ser Arg Thr 
            20                  25                  30          


Pro Val Asn Ile Thr Met Ala Gly Asp Ser Gly Asn Gly Met Ser Thr 
        35                  40                  45              


Phe Ile Ser Ala Leu Arg Asn Thr Gly His Glu Gly Lys Ala Ser Pro 
    50                  55                  60                  


Pro Thr Glu Leu Val Lys Ala Thr Gln Arg Cys Ala Ser Tyr Phe Ser 
65                  70                  75                  80  


Ser His Phe Ser Asn Val Val Leu Trp Asp Leu Pro Gly Thr Gly Ser 
                85                  90                  95      


Ala Thr Thr Thr Leu Glu Asn Tyr Leu Met Glu Met Gln Phe Asn Arg 
            100                 105                 110         


Tyr Asp Phe Ile Met Val Ala Ser Ala Gln Phe Ser Met Asn His Val 
        115                 120                 125             


Met Leu Ala Lys Thr Ala Glu Asp Met Gly Lys Lys Phe Tyr Ile Val 
    130                 135                 140                 


Trp Thr Lys Leu Asp Met Asp Leu Ser Thr Gly Ala Leu Pro Glu Val 
145                 150                 155                 160 


Gln Leu Leu Gln Ile Arg Glu Asn Val Leu Glu Asn Leu Gln Lys Glu 
                165                 170                 175     


Arg Val Cys Glu Tyr 
            180     


<210>  5585
<211>  1242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRS1__Homo_sapiens__NP_005535

<400>  5585

Met Ala Ser Pro Pro Glu Ser Asp Gly Phe Ser Asp Val Arg Lys Val 
1               5                   10                  15      


Gly Tyr Leu Arg Lys Pro Lys Ser Met His Lys Arg Phe Phe Val Leu 
            20                  25                  30          


Arg Ala Ala Ser Glu Ala Gly Gly Pro Ala Arg Leu Glu Tyr Tyr Glu 
        35                  40                  45              


Asn Glu Lys Lys Trp Arg His Lys Ser Ser Ala Pro Lys Arg Ser Ile 
    50                  55                  60                  


Pro Leu Glu Ser Cys Phe Asn Ile Asn Lys Arg Ala Asp Ser Lys Asn 
65                  70                  75                  80  


Lys His Leu Val Ala Leu Tyr Thr Arg Asp Glu His Phe Ala Ile Ala 
                85                  90                  95      


Ala Asp Ser Glu Ala Glu Gln Asp Ser Trp Tyr Gln Ala Leu Leu Gln 
            100                 105                 110         


Leu His Asn Arg Ala Lys Gly His His Asp Gly Ala Ala Ala Leu Gly 
        115                 120                 125             


Ala Gly Gly Gly Gly Gly Ser Cys Ser Gly Ser Ser Gly Leu Gly Glu 
    130                 135                 140                 


Ala Gly Glu Asp Leu Ser Tyr Gly Asp Val Pro Pro Gly Pro Ala Phe 
145                 150                 155                 160 


Lys Glu Val Trp Gln Val Ile Leu Lys Pro Lys Gly Leu Gly Gln Thr 
                165                 170                 175     


Lys Asn Leu Ile Gly Ile Tyr Arg Leu Cys Leu Thr Ser Lys Thr Ile 
            180                 185                 190         


Ser Phe Val Lys Leu Asn Ser Glu Ala Ala Ala Val Val Leu Gln Leu 
        195                 200                 205             


Met Asn Ile Arg Arg Cys Gly His Ser Glu Asn Phe Phe Phe Ile Glu 
    210                 215                 220                 


Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Phe Trp Met Gln Val 
225                 230                 235                 240 


Asp Asp Ser Val Val Ala Gln Asn Met His Glu Thr Ile Leu Glu Ala 
                245                 250                 255     


Met Arg Ala Met Ser Asp Glu Phe Arg Pro Arg Ser Lys Ser Gln Ser 
            260                 265                 270         


Ser Ser Asn Cys Ser Asn Pro Ile Ser Val Pro Leu Arg Arg His His 
        275                 280                 285             


Leu Asn Asn Pro Pro Pro Ser Gln Val Gly Leu Thr Arg Arg Ser Arg 
    290                 295                 300                 


Thr Glu Ser Ile Thr Ala Thr Ser Pro Ala Ser Met Val Gly Gly Lys 
305                 310                 315                 320 


Pro Gly Ser Phe Arg Val Arg Ala Ser Ser Asp Gly Glu Gly Thr Met 
                325                 330                 335     


Ser Arg Pro Ala Ser Val Asp Gly Ser Pro Val Ser Pro Ser Thr Asn 
            340                 345                 350         


Arg Thr His Ala His Arg His Arg Gly Ser Ala Arg Leu His Pro Pro 
        355                 360                 365             


Leu Asn His Ser Arg Ser Ile Pro Met Pro Ala Ser Arg Cys Ser Pro 
    370                 375                 380                 


Ser Ala Thr Ser Pro Val Ser Leu Ser Ser Ser Ser Thr Ser Gly His 
385                 390                 395                 400 


Gly Ser Thr Ser Asp Cys Leu Phe Pro Arg Arg Ser Ser Ala Ser Val 
                405                 410                 415     


Ser Gly Ser Pro Ser Asp Gly Gly Phe Ile Ser Ser Asp Glu Tyr Gly 
            420                 425                 430         


Ser Ser Pro Cys Asp Phe Arg Ser Ser Phe Arg Ser Val Thr Pro Asp 
        435                 440                 445             


Ser Leu Gly His Thr Pro Pro Ala Arg Gly Glu Glu Glu Leu Ser Asn 
    450                 455                 460                 


Tyr Ile Cys Met Gly Gly Lys Gly Pro Ser Thr Leu Thr Ala Pro Asn 
465                 470                 475                 480 


Gly His Tyr Ile Leu Ser Arg Gly Gly Asn Gly His Arg Cys Thr Pro 
                485                 490                 495     


Gly Thr Gly Leu Gly Thr Ser Pro Ala Leu Ala Gly Asp Glu Ala Ala 
            500                 505                 510         


Ser Ala Ala Asp Leu Asp Asn Arg Phe Arg Lys Arg Thr His Ser Ala 
        515                 520                 525             


Gly Thr Ser Pro Thr Ile Thr His Gln Lys Thr Pro Ser Gln Ser Ser 
    530                 535                 540                 


Val Ala Ser Ile Glu Glu Tyr Thr Glu Met Met Pro Ala Tyr Pro Pro 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Arg Leu Pro Gly His Arg His Ser Ala Phe 
                565                 570                 575     


Val Pro Thr Arg Ser Tyr Pro Glu Glu Gly Leu Glu Met His Pro Leu 
            580                 585                 590         


Glu Arg Arg Gly Gly His His Arg Pro Asp Ser Ser Thr Leu His Thr 
        595                 600                 605             


Asp Asp Gly Tyr Met Pro Met Ser Pro Gly Val Ala Pro Val Pro Ser 
    610                 615                 620                 


Gly Arg Lys Gly Ser Gly Asp Tyr Met Pro Met Ser Pro Lys Ser Val 
625                 630                 635                 640 


Ser Ala Pro Gln Gln Ile Ile Asn Pro Ile Arg Arg His Pro Gln Arg 
                645                 650                 655     


Val Asp Pro Asn Gly Tyr Met Met Met Ser Pro Ser Gly Gly Cys Ser 
            660                 665                 670         


Pro Asp Ile Gly Gly Gly Pro Ser Ser Ser Ser Ser Ser Ser Asn Ala 
        675                 680                 685             


Val Pro Ser Gly Thr Ser Tyr Gly Lys Leu Trp Thr Asn Gly Val Gly 
    690                 695                 700                 


Gly His His Ser His Val Leu Pro His Pro Lys Pro Pro Val Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Lys Leu Leu Pro Cys Thr Gly Asp Tyr Met Asn Met Ser 
                725                 730                 735     


Pro Val Gly Asp Ser Asn Thr Ser Ser Pro Ser Asp Cys Tyr Tyr Gly 
            740                 745                 750         


Pro Glu Asp Pro Gln His Lys Pro Val Leu Ser Tyr Tyr Ser Leu Pro 
        755                 760                 765             


Arg Ser Phe Lys His Thr Gln Arg Pro Gly Glu Pro Glu Glu Gly Ala 
    770                 775                 780                 


Arg His Gln His Leu Arg Leu Ser Thr Ser Ser Gly Arg Leu Leu Tyr 
785                 790                 795                 800 


Ala Ala Thr Ala Asp Asp Ser Ser Ser Ser Thr Ser Ser Asp Ser Leu 
                805                 810                 815     


Gly Gly Gly Tyr Cys Gly Ala Arg Leu Glu Pro Ser Leu Pro His Pro 
            820                 825                 830         


His His Gln Val Leu Gln Pro His Leu Pro Arg Lys Val Asp Thr Ala 
        835                 840                 845             


Ala Gln Thr Asn Ser Arg Leu Ala Arg Pro Thr Arg Leu Ser Leu Gly 
    850                 855                 860                 


Asp Pro Lys Ala Ser Thr Leu Pro Arg Ala Arg Glu Gln Gln Gln Gln 
865                 870                 875                 880 


Gln Gln Pro Leu Leu His Pro Pro Glu Pro Lys Ser Pro Gly Glu Tyr 
                885                 890                 895     


Val Asn Ile Glu Phe Gly Ser Asp Gln Ser Gly Tyr Leu Ser Gly Pro 
            900                 905                 910         


Val Ala Phe His Ser Ser Pro Ser Val Arg Cys Pro Ser Gln Leu Gln 
        915                 920                 925             


Pro Ala Pro Arg Glu Glu Glu Thr Gly Thr Glu Glu Tyr Met Lys Met 
    930                 935                 940                 


Asp Leu Gly Pro Gly Arg Arg Ala Ala Trp Gln Glu Ser Thr Gly Val 
945                 950                 955                 960 


Glu Met Gly Arg Leu Gly Pro Ala Pro Pro Gly Ala Ala Ser Ile Cys 
                965                 970                 975     


Arg Pro Thr Arg Ala Val Pro Ser Ser Arg Gly Asp Tyr Met Thr Met 
            980                 985                 990         


Gln Met Ser Cys Pro Arg Gln Ser  Tyr Val Asp Thr Ser  Pro Ala Ala 
        995                 1000                 1005             


Pro Val  Ser Tyr Ala Asp Met  Arg Thr Gly Ile Ala  Ala Glu Glu 
    1010                 1015                 1020             


Val Ser  Leu Pro Arg Ala Thr  Met Ala Ala Ala Ser  Ser Ser Ser 
    1025                 1030                 1035             


Ala Ala  Ser Ala Ser Pro Thr  Gly Pro Gln Gly Ala  Ala Glu Leu 
    1040                 1045                 1050             


Ala Ala  His Ser Ser Leu Leu  Gly Gly Pro Gln Gly  Pro Gly Gly 
    1055                 1060                 1065             


Met Ser  Ala Phe Thr Arg Val  Asn Leu Ser Pro Asn  Arg Asn Gln 
    1070                 1075                 1080             


Ser Ala  Lys Val Ile Arg Ala  Asp Pro Gln Gly Cys  Arg Arg Arg 
    1085                 1090                 1095             


His Ser  Ser Glu Thr Phe Ser  Ser Thr Pro Ser Ala  Thr Arg Val 
    1100                 1105                 1110             


Gly Asn  Thr Val Pro Phe Gly  Ala Gly Ala Ala Val  Gly Gly Gly 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Ser Ser  Glu Asp Val Lys Arg  His Ser Ser 
    1130                 1135                 1140             


Ala Ser  Phe Glu Asn Val Trp  Leu Arg Pro Gly Glu  Leu Gly Gly 
    1145                 1150                 1155             


Ala Pro  Lys Glu Pro Ala Lys  Leu Cys Gly Ala Ala  Gly Gly Leu 
    1160                 1165                 1170             


Glu Asn  Gly Leu Asn Tyr Ile  Asp Leu Asp Leu Val  Lys Asp Phe 
    1175                 1180                 1185             


Lys Gln  Cys Pro Gln Glu Cys  Thr Pro Glu Pro Gln  Pro Pro Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro His Gln Pro  Leu Gly Ser Gly Glu  Ser Ser Ser 
    1205                 1210                 1215             


Thr Arg  Arg Ser Ser Glu Asp  Leu Ser Ala Tyr Ala  Ser Ile Ser 
    1220                 1225                 1230             


Phe Gln  Lys Gln Pro Glu Asp  Arg Gln 
    1235                 1240         


<210>  5586
<211>  1338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRS2__Homo_sapiens__NP_003740

<400>  5586

Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp 
1               5                   10                  15      


Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg 
            20                  25                  30          


Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe 
        35                  40                  45              


Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Glu Ala Thr Ala Gly Gly 
    50                  55                  60                  


Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys 
65                  70                  75                  80  


Lys Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp 
                85                  90                  95      


Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Ala Lys His Lys Tyr Leu 
            100                 105                 110         


Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn 
        115                 120                 125             


Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser 
    130                 135                 140                 


Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala 
145                 150                 155                 160 


Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Leu Gly Gly Ser Ala Gly 
                165                 170                 175     


Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala 
            180                 185                 190         


Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly 
        195                 200                 205             


Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg 
    210                 215                 220                 


Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu 
225                 230                 235                 240 


Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe 
                245                 250                 255     


Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met 
            260                 265                 270         


Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu 
        275                 280                 285             


Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser 
    290                 295                 300                 


Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro 
305                 310                 315                 320 


Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr 
                325                 330                 335     


Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro 
            340                 345                 350         


Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp 
        355                 360                 365             


Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser 
    370                 375                 380                 


Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser 
385                 390                 395                 400 


Arg Ser His Thr Leu Ser Gly Gly Cys Gly Gly Arg Gly Ser Lys Val 
                405                 410                 415     


Ala Leu Leu Pro Ala Gly Gly Ala Leu Gln His Ser Arg Ser Met Ser 
            420                 425                 430         


Met Pro Val Ala His Ser Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu 
        435                 440                 445             


Ser Ser Ser Ser Gly His Gly Ser Gly Ser Tyr Pro Pro Pro Pro Gly 
    450                 455                 460                 


Pro His Pro Pro Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg 
465                 470                 475                 480 


Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly 
                485                 490                 495     


Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala 
            500                 505                 510         


Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro 
        515                 520                 525             


Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr 
    530                 535                 540                 


Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser 
545                 550                 555                 560 


Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr 
                565                 570                 575     


Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser 
            580                 585                 590         


Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser 
        595                 600                 605             


Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala 
    610                 615                 620                 


Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His 
625                 630                 635                 640 


Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met 
                645                 650                 655     


Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser 
            660                 665                 670         


Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln 
        675                 680                 685             


Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Ser 
    690                 695                 700                 


Ala Gly Pro Ala Gly Pro Ala Pro Thr Ser Ala Ala Gly Arg Thr Phe 
705                 710                 715                 720 


Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser 
                725                 730                 735     


Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser 
            740                 745                 750         


Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn 
        755                 760                 765             


Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe 
    770                 775                 780                 


Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly 
785                 790                 795                 800 


Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys 
                805                 810                 815     


Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg 
            820                 825                 830         


Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Ser 
        835                 840                 845             


Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro 
    850                 855                 860                 


Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe 
865                 870                 875                 880 


Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu 
                885                 890                 895     


Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu 
            900                 905                 910         


Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly 
        915                 920                 925             


Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser 
    930                 935                 940                 


Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Ser Ser Leu Gly Ser 
945                 950                 955                 960 


Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser 
                965                 970                 975     


Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly 
            980                 985                 990         


Ala Pro Ser Gly His Pro Val Gly  Ser Leu Asp Gly Leu  Leu Ser Pro 
        995                 1000                 1005             


Glu Ala  Ser Ser Pro Tyr Pro  Pro Leu Pro Pro Arg  Pro Ser Ala 
    1010                 1015                 1020             


Ser Pro  Ser Ser Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Ala Pro 
    1025                 1030                 1035             


Gly Glu  Leu Tyr Arg Leu Pro  Pro Ala Ser Ala Val  Ala Thr Ala 
    1040                 1045                 1050             


Gln Gly  Pro Gly Ala Ala Ser  Ser Leu Ser Ser Asp  Thr Gly Asp 
    1055                 1060                 1065             


Asn Gly  Asp Tyr Thr Glu Met  Ala Phe Gly Val Ala  Ala Thr Pro 
    1070                 1075                 1080             


Pro Gln  Pro Ile Ala Ala Pro  Pro Lys Pro Glu Ala  Ala Arg Val 
    1085                 1090                 1095             


Ala Ser  Pro Thr Ser Gly Val  Lys Arg Leu Ser Leu  Met Glu Gln 
    1100                 1105                 1110             


Val Ser  Gly Val Glu Ala Phe  Leu Gln Ala Ser Gln  Pro Pro Asp 
    1115                 1120                 1125             


Pro His  Arg Gly Ala Lys Val  Ile Arg Ala Asp Pro  Gln Gly Gly 
    1130                 1135                 1140             


Arg Arg  Arg His Ser Ser Glu  Thr Phe Ser Ser Thr  Thr Thr Val 
    1145                 1150                 1155             


Thr Pro  Val Ser Pro Ser Phe  Ala His Asn Pro Lys  Arg His Asn 
    1160                 1165                 1170             


Ser Ala  Ser Val Glu Asn Val  Ser Leu Arg Lys Ser  Ser Glu Gly 
    1175                 1180                 1185             


Gly Val  Gly Val Gly Pro Gly  Gly Gly Asp Glu Pro  Pro Thr Ser 
    1190                 1195                 1200             


Pro Arg  Gln Leu Gln Pro Ala  Pro Pro Leu Ala Pro  Gln Gly Arg 
    1205                 1210                 1215             


Pro Trp  Thr Pro Gly Gln Pro  Gly Gly Leu Val Gly  Cys Pro Gly 
    1220                 1225                 1230             


Ser Gly  Gly Ser Pro Met Arg  Arg Glu Thr Ser Ala  Gly Phe Gln 
    1235                 1240                 1245             


Asn Gly  Leu Asn Tyr Ile Ala  Ile Asp Val Arg Glu  Glu Pro Gly 
    1250                 1255                 1260             


Leu Pro  Pro Gln Pro Gln Pro  Pro Pro Pro Pro Leu  Pro Gln Pro 
    1265                 1270                 1275             


Gly Asp  Lys Ser Ser Trp Gly  Arg Thr Arg Ser Leu  Gly Gly Leu 
    1280                 1285                 1290             


Ile Ser  Ala Val Gly Val Gly  Ser Thr Gly Gly Gly  Cys Gly Gly 
    1295                 1300                 1305             


Pro Gly  Pro Gly Ala Leu Pro  Pro Ala Asn Thr Tyr  Ala Ser Ile 
    1310                 1315                 1320             


Asp Phe  Leu Ser His His Leu  Lys Glu Ala Thr Ile  Val Lys Glu 
    1325                 1330                 1335             


<210>  5587
<211>  1257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRS4__Homo_sapiens__NP_003595

<400>  5587

Met Ala Ser Cys Ser Phe Thr Arg Asp Gln Ala Thr Arg Arg Leu Arg 
1               5                   10                  15      


Gly Ala Ala Ala Ala Ala Ala Ala Ala Leu Ala Ala Val Val Thr Thr 
            20                  25                  30          


Pro Leu Leu Ser Ser Gly Thr Pro Thr Ala Leu Ile Gly Thr Gly Ser 
        35                  40                  45              


Ser Cys Pro Gly Ala Met Trp Leu Ser Thr Ala Thr Gly Ser Arg Ser 
    50                  55                  60                  


Asp Ser Glu Ser Glu Glu Glu Asp Leu Pro Val Gly Glu Glu Val Cys 
65                  70                  75                  80  


Lys Arg Gly Tyr Leu Arg Lys Gln Lys His Gly His Arg Arg Tyr Phe 
                85                  90                  95      


Val Leu Lys Leu Glu Thr Ala Asp Ala Pro Ala Arg Leu Glu Tyr Tyr 
            100                 105                 110         


Glu Asn Ala Arg Lys Phe Arg His Ser Val Arg Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ser Gly Ala Ala Ile Pro Pro Leu Ile Pro Pro 
    130                 135                 140                 


Arg Arg Val Ile Thr Leu Tyr Gln Cys Phe Ser Val Ser Gln Arg Ala 
145                 150                 155                 160 


Asp Ala Arg Tyr Arg His Leu Ile Ala Leu Phe Thr Gln Asp Glu Tyr 
                165                 170                 175     


Phe Ala Met Val Ala Glu Asn Glu Ser Glu Gln Glu Ser Trp Tyr Leu 
            180                 185                 190         


Leu Leu Ser Arg Leu Ile Leu Glu Ser Lys Arg Arg Arg Cys Gly Thr 
        195                 200                 205             


Leu Gly Ala Gln Pro Asp Gly Glu Pro Ala Ala Leu Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Glu Pro Pro Phe Tyr Lys Asp Val Trp Gln Val Ile Val Lys 
225                 230                 235                 240 


Pro Arg Gly Leu Gly His Arg Lys Glu Leu Ser Gly Val Phe Arg Leu 
                245                 250                 255     


Cys Leu Thr Asp Glu Glu Val Val Phe Val Arg Leu Asn Thr Glu Val 
            260                 265                 270         


Ala Ser Val Val Val Gln Leu Leu Ser Ile Arg Arg Cys Gly His Ser 
        275                 280                 285             


Glu Gln Tyr Phe Phe Leu Glu Val Gly Arg Ser Thr Val Ile Gly Pro 
    290                 295                 300                 


Gly Glu Leu Trp Met Gln Val Asp Asp Cys Val Val Ala Gln Asn Met 
305                 310                 315                 320 


His Glu Leu Phe Leu Glu Lys Met Arg Ala Leu Cys Ala Asp Glu Tyr 
                325                 330                 335     


Arg Ala Arg Cys Arg Ser Tyr Ser Ile Ser Ile Gly Ala His Leu Leu 
            340                 345                 350         


Thr Leu Leu Ser Ala Arg Arg His Leu Gly Leu Val Pro Leu Glu Pro 
        355                 360                 365             


Gly Gly Trp Leu Arg Arg Ser Arg Phe Glu Gln Phe Cys His Leu Arg 
    370                 375                 380                 


Ala Ile Gly Asp Gly Glu Asp Glu Met Leu Phe Thr Arg Arg Phe Val 
385                 390                 395                 400 


Thr Pro Ser Glu Pro Val Ala His Ser Arg Arg Gly Arg Leu His Leu 
                405                 410                 415     


Pro Arg Gly Arg Arg Ser Arg Arg Ala Val Ser Val Pro Ala Ser Phe 
            420                 425                 430         


Phe Arg Arg Leu Ala Pro Ser Pro Ala Arg Pro Arg His Pro Ala Glu 
        435                 440                 445             


Ala Pro Asn Asn Gly Ala Arg Leu Ser Ser Glu Val Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Asn Phe Gly Glu Glu Gly Asn Pro Gln Gly Lys Glu Asp Gln 
465                 470                 475                 480 


Glu Gly Ser Gly Gly Asp Tyr Met Pro Met Asn Asn Trp Gly Ser Gly 
                485                 490                 495     


Asn Gly Arg Gly Ser Gly Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser 
            500                 505                 510         


Ser Ser His Ser Ser Gly Gly Asn Gln Cys Ser Gly Glu Gly Gln Gly 
        515                 520                 525             


Ser Arg Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser Gly Gly Asn Gln 
    530                 535                 540                 


Cys Ser Arg Asp Gly Gln Gly Thr Ala Gly Gly His Gly Ser Gly Gly 
545                 550                 555                 560 


Gly Gln Arg Pro Gly Gly Gly His Gly Ser Gly Gly Gly Gln Gly Pro 
                565                 570                 575     


Gly Asp Gly His Gly Ser Gly Gly Gly Lys Asn Ser Gly Gly Gly Lys 
            580                 585                 590         


Gly Ser Gly Ser Gly Lys Gly Ser Asp Gly Asp Gly Glu Arg Gly Lys 
        595                 600                 605             


Ser Leu Lys Lys Arg Ser Tyr Phe Gly Lys Leu Thr Gln Ser Lys Gln 
    610                 615                 620                 


Gln Gln Met Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala 
625                 630                 635                 640 


Gly Gly Thr Gly Gly Lys Gly Lys Ser Gly Gly Arg Phe Arg Leu Tyr 
                645                 650                 655     


Phe Cys Val Asp Arg Gly Ala Thr Lys Glu Cys Lys Glu Ala Lys Glu 
            660                 665                 670         


Val Lys Asp Ala Glu Ile Pro Glu Gly Ala Ala Arg Gly Pro His Arg 
        675                 680                 685             


Ala Arg Ala Phe Asp Glu Asp Glu Asp Asp Pro Tyr Val Pro Met Arg 
    690                 695                 700                 


Pro Gly Val Ala Thr Pro Leu Val Ser Ser Ser Asp Tyr Met Pro Met 
705                 710                 715                 720 


Ala Pro Gln Asn Val Ser Ala Ser Lys Lys Arg His Ser Arg Ser Pro 
                725                 730                 735     


Phe Glu Asp Ser Arg Gly Tyr Met Met Met Phe Pro Arg Val Ser Pro 
            740                 745                 750         


Pro Pro Ala Pro Ser Pro Pro Lys Ala Pro Asp Thr Asn Lys Glu Asp 
        755                 760                 765             


Asp Ser Lys Asp Asn Asp Ser Glu Ser Asp Tyr Met Phe Met Ala Pro 
    770                 775                 780                 


Gly Ala Gly Ala Ile Pro Lys Asn Pro Arg Asn Pro Gln Gly Gly Ser 
785                 790                 795                 800 


Ser Ser Lys Ser Trp Ser Ser Tyr Phe Ser Leu Pro Asn Pro Phe Arg 
                805                 810                 815     


Ser Ser Pro Leu Gly Gln Asn Asp Asn Ser Glu Tyr Val Pro Met Leu 
            820                 825                 830         


Pro Gly Lys Phe Leu Gly Arg Gly Leu Asp Lys Glu Val Ser Tyr Asn 
        835                 840                 845             


Trp Asp Pro Lys Asp Ala Ala Ser Lys Pro Ser Gly Glu Gly Ser Phe 
    850                 855                 860                 


Ser Lys Pro Gly Asp Gly Gly Ser Pro Ser Lys Pro Ser Asp His Glu 
865                 870                 875                 880 


Pro Pro Lys Asn Lys Ala Lys Arg Pro Asn Arg Leu Ser Phe Ile Thr 
                885                 890                 895     


Lys Gly Tyr Lys Ile Lys Pro Lys Pro Gln Lys Pro Thr His Glu Gln 
            900                 905                 910         


Arg Glu Ala Asp Ser Ser Ser Asp Tyr Val Asn Met Asp Phe Thr Lys 
        915                 920                 925             


Arg Glu Ser Asn Thr Pro Ala Pro Ser Thr Gln Gly Leu Pro Asp Ser 
    930                 935                 940                 


Trp Gly Ile Ile Ala Glu Pro Arg Gln Ser Ala Phe Ser Asn Tyr Val 
945                 950                 955                 960 


Asn Val Glu Phe Gly Val Pro Phe Pro Asn Pro Ala Asn Asp Leu Ser 
                965                 970                 975     


Asp Leu Leu Arg Ala Ile Pro Arg Ala Asn Pro Leu Ser Leu Asp Ser 
            980                 985                 990         


Ala Arg Trp Pro Leu Pro Pro Leu  Pro Leu Ser Ala Thr  Gly Ser Asn 
        995                 1000                 1005             


Ala Ile  Glu Glu Glu Gly Asp  Tyr Ile Glu Val Ile  Phe Asn Ser 
    1010                 1015                 1020             


Ala Met  Thr Pro Ala Met Ala  Leu Ala Asp Ser Ala  Ile Arg Tyr 
    1025                 1030                 1035             


Asp Ala  Glu Thr Gly Arg Ile  Tyr Val Val Asp Pro  Phe Ser Glu 
    1040                 1045                 1050             


Cys Cys  Met Asp Ile Ser Leu  Ser Pro Ser Arg Cys  Ser Glu Pro 
    1055                 1060                 1065             


Pro Pro  Val Ala Arg Leu Leu  Gln Glu Glu Glu Gln  Glu Arg Arg 
    1070                 1075                 1080             


Arg Pro  Gln Ser Arg Ser Gln  Ser Phe Phe Ala Ala  Ala Arg Ala 
    1085                 1090                 1095             


Ala Val  Ser Ala Phe Pro Thr  Asp Ser Leu Glu Arg  Asp Leu Ser 
    1100                 1105                 1110             


Pro Ser  Ser Ala Pro Ala Val  Ala Ser Ala Ala Glu  Pro Thr Leu 
    1115                 1120                 1125             


Ala Leu  Ser Gln Val Val Ala  Ala Ala Ser Ala Leu  Ala Ala Ala 
    1130                 1135                 1140             


Pro Gly  Ile Gly Ala Ala Ala  Ala Ala Ala Gly Phe  Asp Ser Ala 
    1145                 1150                 1155             


Ser Ala  Arg Trp Phe Gln Pro  Val Ala Asn Ala Ala  Asp Ala Glu 
    1160                 1165                 1170             


Ala Val  Arg Gly Ala Gln Asp  Val Ala Gly Gly Ser  Asn Pro Gly 
    1175                 1180                 1185             


Ala His  Asn Pro Ser Ala Asn  Leu Ala Arg Gly Asp  Asn Gln Ala 
    1190                 1195                 1200             


Gly Gly  Ala Ala Ala Ala Ala  Ala Ala Pro Glu Pro  Pro Pro Arg 
    1205                 1210                 1215             


Ser Arg  Arg Val Pro Arg Pro  Pro Glu Arg Glu Asp  Ser Asp Asn 
    1220                 1225                 1230             


Asp Asp  Asp Thr His Val Arg  Met Asp Phe Ala Arg  Arg Asp Asn 
    1235                 1240                 1245             


Gln Phe  Asp Ser Pro Lys Arg  Gly Arg 
    1250                 1255         


<210>  5588
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRX1__Homo_sapiens__NP_077313

<400>  5588

Met Ser Phe Pro Gln Leu Gly Tyr Pro Gln Tyr Leu Ser Ala Ala Gly 
1               5                   10                  15      


Pro Gly Ala Tyr Gly Gly Glu Arg Pro Gly Val Leu Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ser Ser Gly Arg Pro Gly Ala Ala Glu Leu 
        35                  40                  45              


Gly Gly Gly Ala Gly Ala Ala Ala Val Thr Ser Val Leu Gly Met Tyr 
    50                  55                  60                  


Ala Ala Ala Gly Pro Tyr Ala Gly Ala Pro Asn Tyr Ser Ala Phe Leu 
65                  70                  75                  80  


Pro Tyr Ala Ala Asp Leu Ser Leu Phe Ser Gln Met Gly Ser Gln Tyr 
                85                  90                  95      


Glu Leu Lys Asp Asn Pro Gly Val His Pro Ala Thr Phe Ala Ala His 
            100                 105                 110         


Thr Ala Pro Ala Tyr Tyr Pro Tyr Gly Gln Phe Gln Tyr Gly Asp Pro 
        115                 120                 125             


Gly Arg Pro Lys Asn Ala Thr Arg Glu Ser Thr Ser Thr Leu Lys Ala 
    130                 135                 140                 


Trp Leu Asn Glu His Arg Lys Asn Pro Tyr Pro Thr Lys Gly Glu Lys 
145                 150                 155                 160 


Ile Met Leu Ala Ile Ile Thr Lys Met Thr Leu Thr Gln Val Ser Thr 
                165                 170                 175     


Trp Phe Ala Asn Ala Arg Arg Arg Leu Lys Lys Glu Asn Lys Val Thr 
            180                 185                 190         


Trp Gly Ala Arg Ser Lys Asp Gln Glu Asp Gly Ala Leu Phe Gly Ser 
        195                 200                 205             


Asp Thr Glu Gly Asp Pro Glu Lys Ala Glu Asp Asp Glu Glu Ile Asp 
    210                 215                 220                 


Leu Glu Ser Ile Asp Ile Asp Lys Ile Asp Glu His Asp Gly Asp Gln 
225                 230                 235                 240 


Ser Asn Glu Asp Asp Glu Asp Lys Ala Glu Ala Pro His Ala Pro Ala 
                245                 250                 255     


Ala Pro Ser Ala Leu Ala Arg Asp Gln Gly Ser Pro Leu Ala Ala Ala 
            260                 265                 270         


Asp Val Leu Lys Pro Gln Asp Ser Pro Leu Gly Leu Ala Lys Glu Ala 
        275                 280                 285             


Pro Glu Pro Gly Ser Thr Arg Leu Leu Ser Pro Gly Ala Ala Ala Gly 
    290                 295                 300                 


Gly Leu Gln Gly Ala Pro His Gly Lys Pro Lys Ile Trp Ser Leu Ala 
305                 310                 315                 320 


Glu Thr Ala Thr Ser Pro Asp Gly Ala Pro Lys Ala Ser Pro Pro Pro 
                325                 330                 335     


Pro Ala Gly His Pro Gly Ala His Gly Pro Ser Ala Gly Ala Pro Leu 
            340                 345                 350         


Gln His Pro Ala Phe Leu Pro Ser His Gly Leu Tyr Thr Cys His Ile 
        355                 360                 365             


Gly Lys Phe Ser Asn Trp Thr Asn Ser Ala Phe Leu Ala Gln Gly Ser 
    370                 375                 380                 


Leu Leu Asn Met Arg Ser Phe Leu Gly Val Gly Ala Pro His Ala Ala 
385                 390                 395                 400 


Pro His Gly Pro His Leu Pro Ala Pro Pro Pro Pro Gln Pro Pro Val 
                405                 410                 415     


Ala Ile Ala Pro Gly Ala Leu Asn Gly Asp Lys Ala Ser Val Arg Ser 
            420                 425                 430         


Ser Pro Thr Leu Pro Glu Arg Asp Leu Val Pro Arg Pro Asp Ser Pro 
        435                 440                 445             


Ala Gln Gln Leu Lys Ser Pro Phe Gln Pro Val Arg Asp Asn Ser Leu 
    450                 455                 460                 


Ala Pro Gln Glu Gly Thr Pro Arg Ile Leu Ala Ala Leu Pro Ser Ala 
465                 470                 475                 480 


<210>  5589
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRX2__Homo_sapiens__NP_150366

<400>  5589

Met Ser Tyr Pro Gln Gly Tyr Leu Tyr Gln Ala Pro Gly Ser Leu Ala 
1               5                   10                  15      


Leu Tyr Ser Cys Pro Ala Tyr Gly Ala Ser Ala Leu Ala Ala Pro Arg 
            20                  25                  30          


Ser Glu Glu Leu Ala Arg Ser Ala Ser Gly Ser Ala Phe Ser Pro Tyr 
        35                  40                  45              


Pro Gly Ser Ala Ala Phe Thr Ala Gln Ala Ala Thr Gly Phe Gly Ser 
    50                  55                  60                  


Pro Leu Gln Tyr Ser Ala Asp Ala Ala Ala Ala Ala Ala Gly Phe Pro 
65                  70                  75                  80  


Ser Tyr Met Gly Ala Pro Tyr Asp Ala His Thr Thr Gly Met Thr Gly 
                85                  90                  95      


Ala Ile Ser Tyr His Pro Tyr Gly Ser Ala Ala Tyr Pro Tyr Gln Leu 
            100                 105                 110         


Asn Asp Pro Ala Tyr Arg Lys Asn Ala Thr Arg Asp Ala Thr Ala Thr 
        115                 120                 125             


Leu Lys Ala Trp Leu Asn Glu His Arg Lys Asn Pro Tyr Pro Thr Lys 
    130                 135                 140                 


Gly Glu Lys Ile Met Leu Ala Ile Ile Thr Lys Met Thr Leu Thr Gln 
145                 150                 155                 160 


Val Ser Thr Trp Phe Ala Asn Ala Arg Arg Arg Leu Lys Lys Glu Asn 
                165                 170                 175     


Lys Met Thr Trp Ala Pro Arg Asn Lys Ser Glu Asp Glu Asp Glu Asp 
            180                 185                 190         


Glu Gly Asp Ala Thr Arg Ser Lys Asp Glu Ser Pro Asp Lys Ala Gln 
        195                 200                 205             


Glu Gly Thr Glu Thr Ser Ala Glu Asp Glu Gly Ile Ser Leu His Val 
    210                 215                 220                 


Asp Ser Leu Thr Asp His Ser Cys Ser Ala Glu Ser Asp Gly Glu Lys 
225                 230                 235                 240 


Leu Pro Cys Arg Ala Gly Asp Pro Leu Cys Glu Ser Gly Ser Glu Cys 
                245                 250                 255     


Lys Asp Lys Tyr Asp Asp Leu Glu Asp Asp Glu Asp Asp Asp Glu Glu 
            260                 265                 270         


Gly Glu Arg Gly Leu Ala Pro Pro Lys Pro Val Thr Ser Ser Pro Leu 
        275                 280                 285             


Thr Gly Leu Glu Ala Pro Leu Leu Ser Pro Pro Pro Glu Ala Ala Pro 
    290                 295                 300                 


Arg Gly Gly Arg Lys Thr Pro Gln Gly Ser Arg Thr Ser Pro Gly Ala 
305                 310                 315                 320 


Pro Pro Pro Ala Ser Lys Pro Lys Leu Trp Ser Leu Ala Glu Ile Ala 
                325                 330                 335     


Thr Ser Asp Leu Lys Gln Pro Ser Leu Gly Pro Gly Cys Gly Pro Pro 
            340                 345                 350         


Gly Leu Pro Ala Ala Ala Ala Pro Ala Ser Thr Gly Ala Pro Pro Gly 
        355                 360                 365             


Gly Ser Pro Tyr Pro Ala Ser Pro Leu Leu Gly Arg Pro Leu Tyr Tyr 
    370                 375                 380                 


Thr Ser Pro Phe Tyr Gly Asn Tyr Thr Asn Tyr Gly Asn Leu Asn Ala 
385                 390                 395                 400 


Ala Leu Gln Gly Gln Gly Leu Leu Arg Tyr Asn Ser Ala Ala Ala Ala 
                405                 410                 415     


Pro Gly Glu Ala Leu His Thr Ala Pro Lys Ala Ala Ser Asp Ala Gly 
            420                 425                 430         


Lys Ala Gly Ala His Pro Leu Glu Ser His Tyr Arg Ser Pro Gly Gly 
        435                 440                 445             


Gly Tyr Glu Pro Lys Lys Asp Ala Ser Glu Gly Cys Thr Val Val Gly 
    450                 455                 460                 


Gly Gly Val Gln Pro Tyr Leu 
465                 470     


<210>  5590
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRX3__Homo_sapiens__NP_077312

<400>  5590

Met Ser Phe Pro Gln Leu Gly Tyr Gln Tyr Ile Arg Pro Leu Tyr Pro 
1               5                   10                  15      


Ser Glu Arg Pro Gly Ala Ala Gly Gly Ser Gly Gly Ser Ala Gly Ala 
            20                  25                  30          


Arg Gly Gly Leu Gly Ala Gly Ala Ser Glu Leu Asn Ala Ser Gly Ser 
        35                  40                  45              


Leu Ser Asn Val Leu Ser Ser Val Tyr Gly Ala Pro Tyr Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Gln Gly Tyr Gly Ala Phe Leu Pro Tyr Ala 
65                  70                  75                  80  


Ala Glu Leu Pro Ile Phe Pro Gln Leu Gly Ala Gln Tyr Glu Leu Lys 
                85                  90                  95      


Asp Ser Pro Gly Val Gln His Pro Ala Ala Ala Ala Ala Phe Pro His 
            100                 105                 110         


Pro His Pro Ala Phe Tyr Pro Tyr Gly Gln Tyr Gln Phe Gly Asp Pro 
        115                 120                 125             


Ser Arg Pro Lys Asn Ala Thr Arg Glu Ser Thr Ser Thr Leu Lys Ala 
    130                 135                 140                 


Trp Leu Asn Glu His Arg Lys Asn Pro Tyr Pro Thr Lys Gly Glu Lys 
145                 150                 155                 160 


Ile Met Leu Ala Ile Ile Thr Lys Met Thr Leu Thr Gln Val Ser Thr 
                165                 170                 175     


Trp Phe Ala Asn Ala Arg Arg Arg Leu Lys Lys Glu Asn Lys Met Thr 
            180                 185                 190         


Trp Ala Pro Arg Ser Arg Thr Asp Glu Glu Gly Asn Ala Tyr Gly Ser 
        195                 200                 205             


Glu Arg Glu Glu Glu Asp Glu Glu Glu Asp Glu Glu Asp Gly Lys Arg 
    210                 215                 220                 


Glu Leu Glu Leu Glu Glu Glu Glu Leu Gly Gly Glu Glu Glu Asp Thr 
225                 230                 235                 240 


Gly Gly Glu Gly Leu Ala Asp Asp Asp Glu Asp Glu Glu Ile Asp Leu 
                245                 250                 255     


Glu Asn Leu Asp Gly Ala Ala Thr Glu Pro Glu Leu Ser Leu Ala Gly 
            260                 265                 270         


Ala Ala Arg Arg Asp Gly Asp Leu Gly Leu Gly Pro Ile Ser Asp Ser 
        275                 280                 285             


Lys Asn Ser Asp Ser Glu Asp Ser Ser Glu Gly Leu Glu Asp Arg Pro 
    290                 295                 300                 


Leu Pro Val Leu Ser Leu Ala Pro Ala Pro Pro Pro Val Ala Val Ala 
305                 310                 315                 320 


Ser Pro Ser Leu Pro Ser Pro Pro Val Ser Leu Asp Pro Cys Ala Pro 
                325                 330                 335     


Ala Pro Ala Pro Ala Ser Ala Leu Gln Lys Pro Lys Ile Trp Ser Leu 
            340                 345                 350         


Ala Glu Thr Ala Thr Ser Pro Asp Asn Pro Arg Arg Ser Pro Pro Gly 
        355                 360                 365             


Ala Gly Gly Ser Pro Pro Gly Ala Ala Val Ala Pro Ser Ala Leu Gln 
    370                 375                 380                 


Leu Ser Pro Ala Ala Ala Ala Ala Ala Ala His Arg Leu Val Ser Ala 
385                 390                 395                 400 


Pro Leu Gly Lys Phe Pro Ala Trp Thr Asn Arg Pro Phe Pro Gly Pro 
                405                 410                 415     


Pro Pro Gly Pro Arg Leu His Pro Leu Ser Leu Leu Gly Ser Ala Pro 
            420                 425                 430         


Pro His Leu Leu Gly Leu Pro Gly Ala Ala Gly His Pro Ala Ala Ala 
        435                 440                 445             


Ala Ala Phe Ala Arg Pro Ala Glu Pro Glu Gly Gly Thr Asp Arg Cys 
    450                 455                 460                 


Ser Ala Leu Glu Val Glu Lys Lys Leu Leu Lys Thr Ala Phe Gln Pro 
465                 470                 475                 480 


Val Pro Arg Arg Pro Gln Asn His Leu Asp Ala Ala Leu Val Leu Ser 
                485                 490                 495     


Ala Leu Ser Ser Ser 
            500     


<210>  5591
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRX4__Homo_sapiens__NP_057442

<400>  5591

Met Ser Tyr Pro Gln Phe Gly Tyr Pro Tyr Ser Ser Ala Pro Gln Phe 
1               5                   10                  15      


Leu Met Ala Thr Asn Ser Leu Ser Thr Cys Cys Glu Ser Gly Gly Arg 
            20                  25                  30          


Thr Leu Ala Asp Ser Gly Pro Ala Ala Ser Ala Gln Ala Pro Val Tyr 
        35                  40                  45              


Cys Pro Val Tyr Glu Ser Arg Leu Leu Ala Thr Ala Arg His Glu Leu 
    50                  55                  60                  


Asn Ser Ala Ala Ala Leu Gly Val Tyr Gly Gly Pro Tyr Gly Gly Ser 
65                  70                  75                  80  


Gln Gly Tyr Gly Asn Tyr Val Thr Tyr Gly Ser Glu Ala Ser Ala Phe 
                85                  90                  95      


Tyr Ser Leu Asn Ser Phe Asp Ser Lys Asp Gly Ser Gly Ser Ala His 
            100                 105                 110         


Gly Gly Leu Ala Pro Ala Ala Ala Ala Tyr Tyr Pro Tyr Glu Pro Ala 
        115                 120                 125             


Leu Gly Gln Tyr Pro Tyr Asp Arg Tyr Gly Thr Met Asp Ser Gly Thr 
    130                 135                 140                 


Arg Arg Lys Asn Ala Thr Arg Glu Thr Thr Ser Thr Leu Lys Ala Trp 
145                 150                 155                 160 


Leu Gln Glu His Arg Lys Asn Pro Tyr Pro Thr Lys Gly Glu Lys Ile 
                165                 170                 175     


Met Leu Ala Ile Ile Thr Lys Met Thr Leu Thr Gln Val Ser Thr Trp 
            180                 185                 190         


Phe Ala Asn Ala Arg Arg Arg Leu Lys Lys Glu Asn Lys Met Thr Trp 
        195                 200                 205             


Pro Pro Arg Asn Lys Cys Ala Asp Glu Lys Arg Pro Tyr Ala Glu Gly 
    210                 215                 220                 


Glu Glu Glu Glu Gly Gly Glu Glu Glu Ala Arg Glu Glu Pro Leu Lys 
225                 230                 235                 240 


Ser Ser Lys Asn Ala Glu Pro Val Gly Lys Glu Glu Lys Glu Leu Glu 
                245                 250                 255     


Leu Ser Asp Leu Asp Asp Phe Asp Pro Leu Glu Ala Glu Pro Pro Ala 
            260                 265                 270         


Cys Glu Leu Lys Pro Pro Phe His Ser Leu Asp Gly Gly Leu Glu Arg 
        275                 280                 285             


Val Pro Ala Ala Pro Asp Gly Pro Val Lys Glu Ala Ser Gly Ala Leu 
    290                 295                 300                 


Arg Met Ser Leu Ala Ala Gly Gly Gly Ala Ala Leu Asp Glu Asp Leu 
305                 310                 315                 320 


Glu Arg Ala Arg Ser Cys Leu Arg Ser Ala Ala Ala Gly Pro Glu Pro 
                325                 330                 335     


Leu Pro Gly Ala Glu Gly Gly Pro Gln Val Cys Glu Ala Lys Leu Gly 
            340                 345                 350         


Phe Val Pro Ala Gly Ala Ser Ala Gly Leu Glu Ala Lys Pro Arg Ile 
        355                 360                 365             


Trp Ser Leu Ala His Thr Ala Thr Ala Ala Ala Ala Ala Ala Thr Ser 
    370                 375                 380                 


Leu Ser Gln Thr Glu Phe Pro Ser Cys Met Leu Lys Arg Gln Gly Pro 
385                 390                 395                 400 


Ala Ala Pro Ala Ala Val Ser Ser Ala Pro Ala Thr Ser Pro Ser Val 
                405                 410                 415     


Ala Leu Pro His Ser Gly Ala Leu Asp Arg His Gln Asp Ser Pro Val 
            420                 425                 430         


Thr Ser Leu Arg Asn Trp Val Asp Gly Val Phe His Asp Pro Ile Leu 
        435                 440                 445             


Arg His Ser Thr Leu Asn Gln Ala Trp Ala Thr Ala Lys Gly Ala Leu 
    450                 455                 460                 


Leu Asp Pro Gly Pro Leu Gly Arg Ser Leu Gly Ala Gly Ala Asn Val 
465                 470                 475                 480 


Leu Thr Ala Pro Leu Ala Arg Ala Phe Pro Pro Ala Val Pro Gln Asp 
                485                 490                 495     


Ala Pro Ala Ala Gly Ala Ala Arg Glu Leu Leu Ala Leu Pro Lys Ala 
            500                 505                 510         


Gly Gly Lys Pro Phe Cys Ala 
        515                 


<210>  5592
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IRX5__Homo_sapiens__NP_001239126

<400>  5592

Met Ser Tyr Pro Gln Gly Tyr Leu Tyr Gln Pro Ser Ala Ser Leu Ala 
1               5                   10                  15      


Leu Tyr Ser Cys Pro Ala Tyr Ser Thr Ser Val Ile Ser Gly Pro Arg 
            20                  25                  30          


Thr Asp Glu Leu Gly Arg Ser Ser Ser Gly Ser Ala Phe Ser Pro Tyr 
        35                  40                  45              


Ala Gly Ser Thr Ala Phe Thr Ala Pro Ser Pro Gly Tyr Asn Ser His 
    50                  55                  60                  


Leu Gln Tyr Gly Ala Asp Pro Ala Ala Ala Ala Ala Ala Ala Phe Ser 
65                  70                  75                  80  


Ser Tyr Val Gly Ser Pro Tyr Asp His Thr Pro Gly Met Ala Gly Ser 
                85                  90                  95      


Leu Gly Tyr His Pro Tyr Ala Ala Pro Leu Gly Ser Tyr Pro Tyr Gly 
            100                 105                 110         


Asp Pro Ala Tyr Arg Lys Asn Ala Thr Arg Asp Ala Thr Ala Thr Leu 
        115                 120                 125             


Lys Ala Trp Leu Asn Glu His Arg Lys Asn Pro Tyr Pro Thr Lys Gly 
    130                 135                 140                 


Glu Lys Ile Met Leu Ala Ile Ile Thr Lys Met Thr Leu Thr Gln Val 
145                 150                 155                 160 


Ser Thr Trp Phe Ala Asn Ala Arg Arg Arg Leu Lys Lys Glu Asn Lys 
                165                 170                 175     


Met Thr Trp Thr Pro Arg Asn Arg Ser Glu Asp Glu Glu Glu Glu Glu 
            180                 185                 190         


Asn Ile Asp Leu Glu Lys Asn Asp Glu Asp Glu Pro Gln Lys Pro Glu 
        195                 200                 205             


Asp Lys Gly Asp Pro Glu Gly Pro Glu Ala Gly Ala Glu Gln Lys Ala 
    210                 215                 220                 


Ala Ser Gly Cys Glu Arg Leu Gln Gly Pro Pro Thr Pro Ala Gly Lys 
225                 230                 235                 240 


Glu Thr Glu Gly Ser Leu Ser Asp Ser Asp Phe Lys Glu Pro Pro Ser 
                245                 250                 255     


Glu Gly Arg Leu Asp Ala Leu Gln Gly Pro Pro Arg Thr Gly Gly Pro 
            260                 265                 270         


Ser Pro Ala Gly Pro Ala Ala Ala Arg Leu Ala Glu Asp Pro Ala Pro 
        275                 280                 285             


His Tyr Pro Ala Gly Ala Pro Ala Pro Gly Pro His Pro Ala Ala Gly 
    290                 295                 300                 


Glu Val Pro Pro Gly Pro Gly Gly Pro Ser Val Ile His Ser Pro Pro 
305                 310                 315                 320 


Pro Pro Pro Pro Pro Ala Val Leu Ala Lys Pro Lys Leu Trp Ser Leu 
                325                 330                 335     


Ala Glu Ile Ala Thr Ser Ser Asp Lys Val Lys Asp Gly Gly Gly Gly 
            340                 345                 350         


Asn Glu Gly Ser Pro Cys Pro Pro Cys Pro Gly Pro Ile Ala Gly Gln 
        355                 360                 365             


Ala Leu Gly Gly Ser Arg Ala Ser Pro Ala Pro Ala Pro Ser Arg Ser 
    370                 375                 380                 


Pro Ser Ala Gln Cys Pro Phe Pro Gly Gly Thr Val Leu Ser Arg Pro 
385                 390                 395                 400 


Leu Tyr Tyr Thr Ala Pro Phe Tyr Pro Gly Tyr Thr Asn Tyr Gly Ser 
                405                 410                 415     


Phe Gly His Leu His Gly His Pro Gly Pro Gly Pro Gly Pro Thr Thr 
            420                 425                 430         


Gly Pro Gly Ser His Phe Asn Gly Leu Asn Gln Thr Val Leu Asn Arg 
        435                 440                 445             


Ala Asp Ala Leu Ala Lys Asp Pro Lys Met Leu Arg Ser Gln Ser Gln 
    450                 455                 460                 


Leu Asp Leu Cys Lys Asp Ser Pro Tyr Glu Leu Lys Lys Gly Met Ser 
465                 470                 475                 480 


Asp Ile 
        


<210>  5593
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISCU__Homo_sapiens__NP_055116

<400>  5593

Met Val Leu Ile Asp Met Ser Val Asp Leu Ser Thr Gln Val Val Asp 
1               5                   10                  15      


His Tyr Glu Asn Pro Arg Asn Val Gly Ser Leu Asp Lys Thr Ser Lys 
            20                  25                  30          


Asn Val Gly Thr Gly Leu Val Gly Ala Pro Ala Cys Gly Asp Val Met 
        35                  40                  45              


Lys Leu Gln Ile Gln Val Asp Glu Lys Gly Lys Ile Val Asp Ala Arg 
    50                  55                  60                  


Phe Lys Thr Phe Gly Cys Gly Ser Ala Ile Ala Ser Ser Ser Leu Ala 
65                  70                  75                  80  


Thr Glu Trp Val Lys Gly Lys Thr Val Glu Glu Ala Leu Thr Ile Lys 
                85                  90                  95      


Asn Thr Asp Ile Ala Lys Glu Leu Cys Leu Pro Pro Val Lys Leu His 
            100                 105                 110         


Cys Ser Met Leu Ala Glu Asp Ala Ile Lys Ala Ala Leu Ala Asp Tyr 
        115                 120                 125             


Lys Leu Lys Gln Glu Pro Lys Lys Gly Glu Ala Glu Lys Lys 
    130                 135                 140         


<210>  5594
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISG20__Homo_sapiens__NP_001290163

<400>  5594

Met Ala Gly Ser Arg Glu Val Val Ala Met Asp Cys Glu Met Val Gly 
1               5                   10                  15      


Leu Gly Pro His Arg Glu Ser Gly Leu Ala Arg Cys Ser Leu Val Asn 
            20                  25                  30          


Val His Gly Ala Val Leu Tyr Asp Lys Phe Ile Arg Pro Glu Gly Glu 
        35                  40                  45              


Ile Thr Asp Tyr Arg Thr Arg Val Ser Gly Val Thr Pro Gln His Met 
    50                  55                  60                  


Val Gly Ala Thr Pro Phe Ala Val Ala Arg Leu Glu Ile Leu Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Lys Leu Val Val Gly His Asp Leu Lys His Asp Phe Gln 
                85                  90                  95      


Ala Leu Lys Glu Asp Met Ser Gly Tyr Thr Ile Tyr Asp Thr Ser Thr 
            100                 105                 110         


Asp Arg Leu Leu Trp Arg Glu Ala Lys Leu Asp His Cys Arg Arg Val 
        115                 120                 125             


Ser Leu Arg Val Leu Ser Glu Arg Leu Leu His Lys Ser Ile Gln Asn 
    130                 135                 140                 


Ser Leu Leu Gly His Ser Ser Val Glu Asp Ala Arg Ala Thr Met Glu 
145                 150                 155                 160 


Leu Tyr Gln Ile Ser Gln Arg Ile Arg Ala Arg Arg Gly Leu Pro Arg 
                165                 170                 175     


Leu Ala Val Ser Asp 
            180     


<210>  5595
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISL1__Homo_sapiens__NP_002193

<400>  5595

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
1               5                   10                  15      


Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
            20                  25                  30          


Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
        35                  40                  45              


Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
    50                  55                  60                  


Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
65                  70                  75                  80  


Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                85                  90                  95      


Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
            100                 105                 110         


Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
        115                 120                 125             


Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
    130                 135                 140                 


Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
145                 150                 155                 160 


Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                165                 170                 175     


Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
            180                 185                 190         


Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
        195                 200                 205             


Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
    210                 215                 220                 


Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
225                 230                 235                 240 


Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                245                 250                 255     


Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
            260                 265                 270         


His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
        275                 280                 285             


Pro Pro Trp Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp 
    290                 295                 300                 


Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
305                 310                 315                 320 


Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                325                 330                 335     


Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
            340                 345                 


<210>  5596
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISM1__Homo_sapiens__NP_543016

<400>  5596

Met Val Arg Leu Ala Ala Glu Leu Leu Leu Leu Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Thr Leu His Ile Thr Val Leu Arg Gly Ser Gly Ala Ala Asp Gly 
            20                  25                  30          


Pro Asp Ala Ala Ala Gly Asn Ala Ser Gln Ala Gln Leu Gln Asn Asn 
        35                  40                  45              


Leu Asn Val Gly Ser Asp Thr Thr Ser Glu Thr Ser Phe Ser Leu Ser 
    50                  55                  60                  


Lys Glu Ala Pro Arg Glu His Leu Asp His Gln Ala Ala His Gln Pro 
65                  70                  75                  80  


Phe Pro Arg Pro Arg Phe Arg Gln Glu Thr Gly His Pro Ser Leu Gln 
                85                  90                  95      


Arg Asp Phe Pro Arg Ser Phe Leu Leu Asp Leu Pro Asn Phe Pro Asp 
            100                 105                 110         


Leu Ser Lys Ala Asp Ile Asn Gly Gln Asn Pro Asn Ile Gln Val Thr 
        115                 120                 125             


Ile Glu Val Val Asp Gly Pro Asp Ser Glu Ala Asp Lys Asp Gln His 
    130                 135                 140                 


Pro Glu Asn Lys Pro Ser Trp Ser Val Pro Ser Pro Asp Trp Arg Ala 
145                 150                 155                 160 


Trp Trp Gln Arg Ser Leu Ser Leu Ala Arg Ala Asn Ser Gly Asp Gln 
                165                 170                 175     


Asp Tyr Lys Tyr Asp Ser Thr Ser Asp Asp Ser Asn Phe Leu Asn Pro 
            180                 185                 190         


Pro Arg Gly Trp Asp His Thr Ala Pro Gly His Arg Thr Phe Glu Thr 
        195                 200                 205             


Lys Asp Gln Pro Glu Tyr Asp Ser Thr Asp Gly Glu Gly Asp Trp Ser 
    210                 215                 220                 


Leu Trp Ser Val Cys Ser Val Thr Cys Gly Asn Gly Asn Gln Lys Arg 
225                 230                 235                 240 


Thr Arg Ser Cys Gly Tyr Ala Cys Thr Ala Thr Glu Ser Arg Thr Cys 
                245                 250                 255     


Asp Arg Pro Asn Cys Pro Gly Ile Glu Asp Thr Phe Arg Thr Ala Ala 
            260                 265                 270         


Thr Glu Val Ser Leu Leu Ala Gly Ser Glu Glu Phe Asn Ala Thr Lys 
        275                 280                 285             


Leu Phe Glu Val Asp Thr Asp Ser Cys Glu Arg Trp Met Ser Cys Lys 
    290                 295                 300                 


Ser Glu Phe Leu Lys Lys Tyr Met His Lys Val Met Asn Asp Leu Pro 
305                 310                 315                 320 


Ser Cys Pro Cys Ser Tyr Pro Thr Glu Val Ala Tyr Ser Thr Ala Asp 
                325                 330                 335     


Ile Phe Asp Arg Ile Lys Arg Lys Asp Phe Arg Trp Lys Asp Ala Ser 
            340                 345                 350         


Gly Pro Lys Glu Lys Leu Glu Ile Tyr Lys Pro Thr Ala Arg Tyr Cys 
        355                 360                 365             


Ile Arg Ser Met Leu Ser Leu Glu Ser Thr Thr Leu Ala Ala Gln His 
    370                 375                 380                 


Cys Cys Tyr Gly Asp Asn Met Gln Leu Ile Thr Arg Gly Lys Gly Ala 
385                 390                 395                 400 


Gly Thr Pro Asn Leu Ile Ser Thr Glu Phe Ser Ala Glu Leu His Tyr 
                405                 410                 415     


Lys Val Asp Val Leu Pro Trp Ile Ile Cys Lys Gly Asp Trp Ser Arg 
            420                 425                 430         


Tyr Asn Glu Ala Arg Pro Pro Asn Asn Gly Gln Lys Cys Thr Glu Ser 
        435                 440                 445             


Pro Ser Asp Glu Asp Tyr Ile Lys Gln Phe Gln Glu Ala Arg Glu Tyr 
    450                 455                 460                 


<210>  5597
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISM2__Homo_sapiens__NP_872315

<400>  5597

Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro 
            20                  25                  30          


Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Val 
        35                  40                  45              


Ser Ala Ser Pro Asp Pro Arg Pro Leu Lys Glu Glu Glu Glu Ala Pro 
    50                  55                  60                  


Leu Leu Pro Arg Thr His Leu Gln Ala Glu Pro His Gln His Gly Cys 
65                  70                  75                  80  


Trp Thr Val Thr Glu Pro Ala Ala Met Thr Pro Gly Asn Ala Thr Pro 
                85                  90                  95      


Pro Arg Thr Pro Glu Val Thr Pro Leu Arg Leu Glu Leu Gln Lys Leu 
            100                 105                 110         


Pro Gly Leu Ala Asn Thr Thr Leu Ser Thr Pro Asn Pro Asp Thr Gln 
        115                 120                 125             


Ala Ser Ala Ser Pro Asp Pro Arg Pro Leu Arg Glu Glu Glu Glu Ala 
    130                 135                 140                 


Arg Leu Leu Pro Arg Thr His Leu Gln Ala Glu Leu His Gln His Gly 
145                 150                 155                 160 


Cys Trp Thr Val Thr Glu Pro Ala Ala Leu Thr Pro Gly Asn Ala Thr 
                165                 170                 175     


Pro Pro Arg Thr Gln Glu Val Thr Pro Leu Leu Leu Glu Leu Gln Lys 
            180                 185                 190         


Leu Pro Glu Leu Val His Ala Thr Leu Ser Thr Pro Asn Pro Asp Asn 
        195                 200                 205             


Gln Thr Met Ser Leu Arg Arg Ser Gly Val Pro Gly Leu Pro Ala Val 
    210                 215                 220                 


Gly Thr Ala Ala Leu Ala Ser Ser Arg Gly Leu Gly Pro Val Ala Met 
225                 230                 235                 240 


Ala Ala Leu Pro Pro Arg Pro Val Pro Val Thr Cys Pro Pro Val Leu 
                245                 250                 255     


Ala Leu Arg Thr Arg Thr Pro Trp Ala Ser Pro Val Arg Ser Gly Ser 
            260                 265                 270         


Ser Trp Pro Ala Met Leu Arg Thr Cys Met Ile Lys Met Trp Thr Ala 
        275                 280                 285             


Val Arg Ser Gly 
    290         


<210>  5598
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISPD__Homo_sapiens__NP_001094896

<400>  5598

Met Glu Ala Gly Pro Pro Gly Ser Ala Arg Pro Ala Glu Pro Gly Pro 
1               5                   10                  15      


Cys Leu Ser Gly Gln Arg Gly Ala Asp His Thr Ala Ser Ala Ser Leu 
            20                  25                  30          


Gln Ser Val Ala Gly Thr Glu Pro Gly Arg His Pro Gln Ala Val Ala 
        35                  40                  45              


Ala Val Leu Pro Ala Gly Gly Cys Gly Glu Arg Met Gly Val Pro Thr 
    50                  55                  60                  


Pro Lys Gln Phe Cys Pro Ile Leu Glu Arg Pro Leu Ile Ser Tyr Thr 
65                  70                  75                  80  


Leu Gln Ala Leu Glu Arg Val Cys Trp Ile Lys Asp Ile Val Val Ala 
                85                  90                  95      


Val Thr Gly Glu Asn Met Glu Val Met Lys Ser Ile Ile Gln Lys Tyr 
            100                 105                 110         


Gln His Lys Arg Ile Ser Leu Val Glu Ala Gly Val Thr Arg His Arg 
        115                 120                 125             


Ser Ile Phe Asn Gly Leu Lys Ala Leu Ala Glu Asp Gln Ile Asn Ser 
    130                 135                 140                 


Lys Leu Ser Lys Pro Glu Val Val Ile Ile His Asp Ala Val Arg Pro 
145                 150                 155                 160 


Phe Val Glu Glu Gly Val Leu Leu Lys Val Val Thr Ala Ala Lys Glu 
                165                 170                 175     


His Gly Ala Ala Gly Ala Ile Arg Pro Leu Val Ser Thr Val Val Ser 
            180                 185                 190         


Pro Ser Ala Asp Gly Cys Leu Asp Tyr Ser Leu Glu Arg Ala Arg His 
        195                 200                 205             


Arg Ala Ser Glu Met Pro Gln Ala Phe Leu Phe Asp Val Ile Tyr Glu 
    210                 215                 220                 


Ala Tyr Gln Gln Cys Ser Asp Tyr Asp Leu Glu Phe Gly Thr Glu Cys 
225                 230                 235                 240 


Leu Gln Leu Ala Leu Lys Tyr Cys Cys Thr Lys Ala Lys Leu Val Glu 
                245                 250                 255     


Gly Ser Pro Asp Leu Trp Lys Val Thr Tyr Lys Arg Asp Leu Tyr Ala 
            260                 265                 270         


Ala Glu Ser Ile Ile Lys Glu Arg Ile Ser Gln Glu Ile Cys Val Val 
        275                 280                 285             


Met Asp Thr Glu Glu Asp Asn Lys His Val Gly His Leu Leu Glu Glu 
    290                 295                 300                 


Val Leu Lys Ser Glu Leu Asn His Val Lys Val Thr Ser Glu Ala Leu 
305                 310                 315                 320 


Gly His Ala Gly Arg His Leu Gln Gln Ile Ile Leu Asp Gln Cys Tyr 
                325                 330                 335     


Asn Phe Val Cys Val Asn Val Thr Thr Ser Asp Phe Gln Glu Thr Gln 
            340                 345                 350         


Lys Leu Leu Ser Met Leu Glu Glu Ser Ser Leu Cys Ile Leu Tyr Pro 
        355                 360                 365             


Val Val Val Val Ser Val His Phe Leu Asp Phe Lys Leu Val Pro Pro 
    370                 375                 380                 


Ser Gln Lys Met Glu Asn Leu Met Gln Ile Arg Glu Phe Ala Lys Glu 
385                 390                 395                 400 


Val Lys Glu Arg Asn Ile Leu Leu Tyr Gly Leu Leu Ile Ser Tyr Pro 
                405                 410                 415     


Gln Asp Asp Gln Lys Leu Gln Glu Ser Leu Arg Gln Gly Ala Ile Ile 
            420                 425                 430         


Ile Ala Ser Leu Ile Lys Glu Arg Asn Ser Gly Leu Ile Gly Gln Leu 
        435                 440                 445             


Leu Ile Ala 
    450     


<210>  5599
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IST1__Homo_sapiens__NP_001257904

<400>  5599

Met Leu Gly Ser Gly Phe Lys Ala Glu Arg Leu Arg Val Asn Leu Arg 
1               5                   10                  15      


Leu Val Ile Asn Arg Leu Lys Leu Leu Glu Lys Lys Lys Thr Glu Leu 
            20                  25                  30          


Ala Gln Lys Ala Arg Lys Glu Ile Ala Asp Tyr Leu Ala Ala Gly Lys 
        35                  40                  45              


Asp Glu Arg Ala Arg Ile Arg Val Glu His Ile Ile Arg Glu Asp Tyr 
    50                  55                  60                  


Leu Val Glu Ala Met Glu Ile Leu Glu Leu Tyr Cys Asp Leu Leu Leu 
65                  70                  75                  80  


Ala Arg Phe Gly Leu Ile Gln Ser Met Lys Glu Leu Asp Ser Gly Leu 
                85                  90                  95      


Ala Glu Ser Val Ser Thr Leu Ile Trp Ala Ala Pro Arg Leu Gln Ser 
            100                 105                 110         


Glu Val Ala Glu Leu Lys Ile Val Ala Asp Gln Leu Cys Ala Lys Tyr 
        115                 120                 125             


Ser Lys Glu Tyr Gly Lys Leu Cys Arg Thr Asn Gln Ile Gly Thr Val 
    130                 135                 140                 


Asn Asp Arg Leu Met His Lys Leu Ser Val Glu Ala Pro Pro Lys Ile 
145                 150                 155                 160 


Leu Val Glu Arg Tyr Leu Ile Glu Ile Ala Lys Asn Tyr Asn Val Pro 
                165                 170                 175     


Tyr Glu Pro Asp Ser Val Val Met Ala Glu Ala Pro Pro Gly Val Glu 
            180                 185                 190         


Thr Asp Leu Ile Asp Val Gly Phe Thr Asp Asp Val Lys Lys Gly Gly 
        195                 200                 205             


Pro Gly Arg Gly Gly Ser Gly Gly Phe Thr Ala Pro Val Gly Gly Pro 
    210                 215                 220                 


Asp Gly Thr Val Pro Met Pro Met Pro Met Pro Met Pro Met Pro Ser 
225                 230                 235                 240 


Ala Asn Thr Pro Phe Ser Tyr Pro Leu Pro Lys Gly Pro Ser Asp Phe 
                245                 250                 255     


Asn Gly Leu Pro Met Gly Thr Tyr Gln Ala Phe Pro Asn Ile His Pro 
            260                 265                 270         


Pro Gln Ile Pro Ala Thr Pro Pro Ser Tyr Glu Ser Val Asp Asp Ile 
        275                 280                 285             


Asn Ala Asp Lys Asn Ile Ser Ser Ala Gln Ile Val Gly Pro Gly Pro 
    290                 295                 300                 


Lys Pro Glu Ala Ser Ala Lys Leu Pro Ser Arg Pro Ala Asp Asn Tyr 
305                 310                 315                 320 


Asp Asn Phe Val Leu Pro Glu Leu Pro Ser Val Pro Asp Thr Leu Pro 
                325                 330                 335     


Thr Ala Ser Ala Gly Ala Ser Thr Ser Ala Ser Glu Asp Ile Asp Phe 
            340                 345                 350         


Asp Asp Leu Ser Arg Arg Phe Glu Glu Leu Lys Lys Lys Thr 
        355                 360                 365     


<210>  5600
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISX__Homo_sapiens__NP_001290437

<400>  5600

Met Cys Ala Glu Val Gly Pro Ala Leu Cys Arg Gly Met Glu Arg Asn 
1               5                   10                  15      


Ser Leu Gly Cys Cys Glu Ala Pro Lys Lys Leu Ser Leu Ser Phe Ser 
            20                  25                  30          


Ile Glu Ala Ile Leu Lys Arg Pro Ala Arg Arg Ser Asp Met Asp Arg 
        35                  40                  45              


Pro Glu Gly Pro Gly Glu Glu Gly Pro Gly Glu Ala Ala Ala Ser Gly 
    50                  55                  60                  


Ser Gly Leu Glu Lys Pro Pro Lys Asp Gln Pro Gln Glu Gly Arg Lys 
65                  70                  75                  80  


Ser Lys Arg Arg Val Arg Thr Thr Phe Thr Thr Glu Gln Leu His Glu 
                85                  90                  95      


Leu Glu Lys Ile Phe His Phe Thr His Tyr Pro Asp Val His Ile Arg 
            100                 105                 110         


Ser Gln Leu Ala Ala Arg Ile Asn Leu Pro Glu Ala Arg Val Gln Ile 
        115                 120                 125             


Trp Phe Gln Asn Gln Arg Ala Lys Trp Arg Lys Gln Glu Lys Ile Gly 
    130                 135                 140                 


Asn Leu Gly Ala Pro Gln Gln Leu Ser Glu Ala Ser Val Ala Leu Pro 
145                 150                 155                 160 


Thr Asn Leu Asp Val Ala Gly Pro Thr Trp Thr Ser Thr Ala Leu Arg 
                165                 170                 175     


Arg Leu Ala Pro Pro Thr Ser Cys Cys Pro Ser Ala Gln Asp Gln Leu 
            180                 185                 190         


Ala Ser Ala Trp Phe Pro Ala Trp Ile Thr Leu Leu Pro Ala His Pro 
        195                 200                 205             


Trp Glu Thr Gln Pro Val Pro Gly Leu Pro Ile His Gln Thr Cys Ile 
    210                 215                 220                 


Pro Val Leu Cys Ile Leu Pro Pro Pro His Pro Lys Trp Gly Ser Ile 
225                 230                 235                 240 


Cys Ala Thr Ser Thr 
                245 


<210>  5601
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISYNA1__Homo_sapiens__NP_001164409

<400>  5601

Met Glu Ala Ala Ala Gln Phe Phe Val Glu Ser Pro Asp Val Val Tyr 
1               5                   10                  15      


Gly Pro Glu Ala Ile Glu Ala Gln Tyr Glu Tyr Arg Thr Thr Arg Val 
            20                  25                  30          


Ser Arg Glu Gly Gly Val Leu Lys Glu Ala Asn Tyr Tyr Gly Ser Leu 
        35                  40                  45              


Thr Gln Ala Gly Thr Val Ser Leu Gly Leu Asp Ala Glu Gly Gln Glu 
    50                  55                  60                  


Val Phe Val Pro Phe Ser Ala Val Leu Pro Met Val Ala Pro Asn Asp 
65                  70                  75                  80  


Leu Val Phe Asp Gly Trp Asp Ile Ser Ser Leu Asn Leu Ala Glu Ala 
                85                  90                  95      


Met Arg Arg Ala Lys Val Leu Asp Trp Gly Leu Gln Glu Gln Leu Trp 
            100                 105                 110         


Pro His Met Glu Ala Leu Arg Pro Arg Pro Ser Val Tyr Ile Pro Glu 
        115                 120                 125             


Phe Ile Ala Ala Asn Gln Ser Ala Arg Ala Asp Asn Leu Ile Pro Gly 
    130                 135                 140                 


Ser Arg Ala Gln Gln Leu Glu Gln Ile Arg Arg Asp Ile Arg Asp Phe 
145                 150                 155                 160 


Arg Ser Ser Ala Gly Leu Asp Lys Val Ile Val Leu Trp Thr Ala Asn 
                165                 170                 175     


Thr Glu Arg Phe Cys Glu Val Ile Pro Gly Leu Asn Asp Thr Ala Glu 
            180                 185                 190         


Asn Leu Leu Arg Thr Ile Glu Leu Gly Leu Glu Val Ser Pro Ser Thr 
        195                 200                 205             


Leu Phe Ala Val Ala Ser Ile Leu Glu Gly Cys Ala Phe Leu Asn Gly 
    210                 215                 220                 


Ser Pro Gln Asn Thr Leu Val Pro Gly Ala Leu Glu Leu Ala Trp Gln 
225                 230                 235                 240 


His Arg Val Phe Val Gly Gly Asp Asp Phe Lys Ser Gly Gln Thr Lys 
                245                 250                 255     


Val Lys Ser Val Leu Val Asp Phe Leu Ile Gly Ser Gly Leu Lys Thr 
            260                 265                 270         


Met Ser Ile Val Ser Tyr Asn His Leu Gly Asn Asn Asp Gly Glu Asn 
        275                 280                 285             


Leu Ser Ala Pro Leu Gln Phe Arg Ser Lys Glu Val Ser Lys Ser Asn 
    290                 295                 300                 


Val Val Asp Asp Met Val Gln Ser Asn Pro Val Leu Tyr Thr Pro Gly 
305                 310                 315                 320 


Glu Glu Pro Asp His Cys Val Val Ile Lys Tyr Val Pro Tyr Val Gly 
                325                 330                 335     


Asp Ser Lys Arg Ala Leu Asp Glu Tyr Thr Ser Glu Leu Met Leu Gly 
            340                 345                 350         


Gly Thr Asn Thr Leu Val Leu His Asn Thr Cys Glu Asp Ser Leu Leu 
        355                 360                 365             


Ala Ala Pro Ile Met Leu Asp Leu Ala Leu Leu Thr Glu Leu Cys Gln 
    370                 375                 380                 


Arg Val Ser Phe Cys Thr Asp Met Asp Pro Glu Pro Gln Thr Phe His 
385                 390                 395                 400 


Pro Val Leu Ser Leu Leu Ser Phe Leu Phe Lys Ala Pro Leu Val Pro 
                405                 410                 415     


Pro Gly Ser Pro Val Val Asn Ala Leu Phe Arg Gln Arg Ser Cys Ile 
            420                 425                 430         


Glu Asn Ile Leu Arg Ala Cys Val Gly Leu Pro Pro Gln Asn His Met 
        435                 440                 445             


Leu Leu Glu His Lys Met Glu Arg Pro Gly Pro Ser Leu Lys Arg Val 
    450                 455                 460                 


Gly Pro Val Ala Ala Thr Tyr Pro Met Leu Asn Lys Lys Gly Pro Val 
465                 470                 475                 480 


Pro Ala Ala Thr Asn Gly Cys Thr Gly Asp Ala Asn Gly His Leu Gln 
                485                 490                 495     


Glu Glu Pro Pro Met Pro Thr Thr 
            500                 


<210>  5602
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITCH__Homo_sapiens__NP_001244066

<400>  5602

Met Ser Asp Ser Gly Ser Gln Leu Gly Ser Met Gly Ser Leu Thr Met 
1               5                   10                  15      


Lys Ser Gln Leu Gln Ile Thr Val Ile Ser Ala Lys Leu Lys Glu Asn 
            20                  25                  30          


Lys Lys Asn Trp Phe Gly Pro Ser Pro Tyr Val Glu Val Thr Val Asp 
        35                  40                  45              


Gly Gln Ser Lys Lys Thr Glu Lys Cys Asn Asn Thr Asn Ser Pro Lys 
    50                  55                  60                  


Trp Lys Gln Pro Leu Thr Val Ile Val Thr Pro Val Ser Lys Leu His 
65                  70                  75                  80  


Phe Arg Val Trp Ser His Gln Thr Leu Lys Ser Asp Val Leu Leu Gly 
                85                  90                  95      


Thr Ala Ala Leu Asp Ile Tyr Glu Thr Leu Lys Ser Asn Asn Met Lys 
            100                 105                 110         


Leu Glu Glu Val Val Val Thr Leu Gln Leu Gly Gly Asp Lys Glu Pro 
        115                 120                 125             


Thr Glu Thr Ile Gly Asp Leu Ser Ile Cys Leu Asp Gly Leu Gln Leu 
    130                 135                 140                 


Glu Ser Glu Val Val Thr Asn Gly Glu Thr Thr Cys Ser Glu Asn Gly 
145                 150                 155                 160 


Val Ser Leu Cys Leu Pro Arg Leu Glu Cys Asn Ser Ala Ile Ser Ala 
                165                 170                 175     


His Cys Asn Leu Cys Leu Pro Gly Leu Ser Asp Ser Pro Ile Ser Ala 
            180                 185                 190         


Ser Arg Val Ala Gly Phe Thr Gly Ala Ser Gln Asn Asp Asp Gly Ser 
        195                 200                 205             


Arg Ser Lys Asp Glu Thr Arg Val Ser Thr Asn Gly Ser Asp Asp Pro 
    210                 215                 220                 


Glu Asp Ala Gly Ala Gly Glu Asn Arg Arg Val Ser Gly Asn Asn Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asn Gly Gly Phe Lys Pro Ser Arg Pro Pro Arg Pro 
                245                 250                 255     


Ser Arg Pro Pro Pro Pro Thr Pro Arg Arg Pro Ala Ser Val Asn Gly 
            260                 265                 270         


Ser Pro Ser Ala Thr Ser Glu Ser Asp Gly Ser Ser Thr Gly Ser Leu 
        275                 280                 285             


Pro Pro Thr Asn Thr Asn Thr Asn Thr Ser Glu Gly Ala Thr Ser Gly 
    290                 295                 300                 


Leu Ile Ile Pro Leu Thr Ile Ser Gly Gly Ser Gly Pro Arg Pro Leu 
305                 310                 315                 320 


Asn Pro Val Thr Gln Ala Pro Leu Pro Pro Gly Trp Glu Gln Arg Val 
                325                 330                 335     


Asp Gln His Gly Arg Val Tyr Tyr Val Asp His Val Glu Lys Arg Thr 
            340                 345                 350         


Thr Trp Asp Arg Pro Glu Pro Leu Pro Pro Gly Trp Glu Arg Arg Val 
        355                 360                 365             


Asp Asn Met Gly Arg Ile Tyr Tyr Val Asp His Phe Thr Arg Thr Thr 
    370                 375                 380                 


Thr Trp Gln Arg Pro Thr Leu Glu Ser Val Arg Asn Tyr Glu Gln Trp 
385                 390                 395                 400 


Gln Leu Gln Arg Ser Gln Leu Gln Gly Ala Met Gln Gln Phe Asn Gln 
                405                 410                 415     


Arg Phe Ile Tyr Gly Asn Gln Asp Leu Phe Ala Thr Ser Gln Ser Lys 
            420                 425                 430         


Glu Phe Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr 
        435                 440                 445             


Asp Ser Asn Gly Arg Val Tyr Phe Val Asn His Asn Thr Arg Ile Thr 
    450                 455                 460                 


Gln Trp Glu Asp Pro Arg Ser Gln Gly Gln Leu Asn Glu Lys Pro Leu 
465                 470                 475                 480 


Pro Glu Gly Trp Glu Met Arg Phe Thr Val Asp Gly Ile Pro Tyr Phe 
                485                 490                 495     


Val Asp His Asn Arg Arg Thr Thr Thr Tyr Ile Asp Pro Arg Thr Gly 
            500                 505                 510         


Lys Ser Ala Leu Asp Asn Gly Pro Gln Ile Ala Tyr Val Arg Asp Phe 
        515                 520                 525             


Lys Ala Lys Val Gln Tyr Phe Arg Phe Trp Cys Gln Gln Leu Ala Met 
    530                 535                 540                 


Pro Gln His Ile Lys Ile Thr Val Thr Arg Lys Thr Leu Phe Glu Asp 
545                 550                 555                 560 


Ser Phe Gln Gln Ile Met Ser Phe Ser Pro Gln Asp Leu Arg Arg Arg 
                565                 570                 575     


Leu Trp Val Ile Phe Pro Gly Glu Glu Gly Leu Asp Tyr Gly Gly Val 
            580                 585                 590         


Ala Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met 
        595                 600                 605             


Tyr Cys Leu Phe Glu Tyr Ala Gly Lys Asp Asn Tyr Cys Leu Gln Ile 
    610                 615                 620                 


Asn Pro Ala Ser Tyr Ile Asn Pro Asp His Leu Lys Tyr Phe Arg Phe 
625                 630                 635                 640 


Ile Gly Arg Phe Ile Ala Met Ala Leu Phe His Gly Lys Phe Ile Asp 
                645                 650                 655     


Thr Gly Phe Ser Leu Pro Phe Tyr Lys Arg Ile Leu Asn Lys Pro Val 
            660                 665                 670         


Gly Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Leu 
        675                 680                 685             


Ile Trp Val Lys Glu Asn Asn Ile Glu Glu Cys Asp Leu Glu Met Tyr 
    690                 695                 700                 


Phe Ser Val Asp Lys Glu Ile Leu Gly Glu Ile Lys Ser His Asp Leu 
705                 710                 715                 720 


Lys Pro Asn Gly Gly Asn Ile Leu Val Thr Glu Glu Asn Lys Glu Glu 
                725                 730                 735     


Tyr Ile Arg Met Val Ala Glu Trp Arg Leu Ser Arg Gly Val Glu Glu 
            740                 745                 750         


Gln Thr Gln Ala Phe Phe Glu Gly Phe Asn Glu Ile Leu Pro Gln Gln 
        755                 760                 765             


Tyr Leu Gln Tyr Phe Asp Ala Lys Glu Leu Glu Val Leu Leu Cys Gly 
    770                 775                 780                 


Met Gln Glu Ile Asp Leu Asn Asp Trp Gln Arg His Ala Ile Tyr Arg 
785                 790                 795                 800 


His Tyr Ala Arg Thr Ser Lys Gln Ile Met Trp Phe Trp Gln Phe Val 
                805                 810                 815     


Lys Glu Ile Asp Asn Glu Lys Arg Met Arg Leu Leu Gln Phe Val Thr 
            820                 825                 830         


Gly Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Asp Leu Met Gly Ser 
        835                 840                 845             


Asn Gly Pro Gln Lys Phe Cys Ile Glu Lys Val Gly Lys Glu Asn Trp 
    850                 855                 860                 


Leu Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr 
865                 870                 875                 880 


Lys Ser Tyr Glu Gln Leu Lys Glu Lys Leu Leu Phe Ala Ile Glu Glu 
                885                 890                 895     


Thr Glu Gly Phe Gly Gln Glu 
            900             


<210>  5603
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITFG1__Homo_sapiens__NP_001291931

<400>  5603

Met Asp Val Leu Leu Thr Tyr Leu Pro Lys Asn Tyr Ala Lys Ser Glu 
1               5                   10                  15      


Leu Gly Ala Val Ile Phe Trp Gly Gln Asn Gln Thr Leu Asp Pro Asn 
            20                  25                  30          


Asn Met Thr Ile Leu Asn Arg Thr Phe Gln Asp Glu Pro Leu Ile Met 
        35                  40                  45              


Asp Phe Asn Gly Asp Leu Ile Pro Asp Ile Phe Gly Ile Thr Asn Glu 
    50                  55                  60                  


Ser Asn Gln Pro Gln Ile Leu Leu Gly Gly Asn Leu Ser Trp His Pro 
65                  70                  75                  80  


Ala Leu Thr Thr Thr Ser Lys Met Arg Ile Pro His Ser His Ala Phe 
                85                  90                  95      


Ile Asp Leu Thr Glu Asp Phe Thr Ala Asp Leu Phe Leu Thr Thr Leu 
            100                 105                 110         


Asn Ala Thr Thr Ser Thr Phe Gln Phe Glu Ile Trp Glu Asn Leu Asp 
        115                 120                 125             


Gly Asn Phe Ser Val Ser Thr Ile Leu Glu Lys Pro Gln Asn Met Met 
    130                 135                 140                 


Val Val Gly Gln Ser Ala Phe Ala Asp Phe Asp Gly Asp Gly His Met 
145                 150                 155                 160 


Asp His Leu Leu Pro Gly Cys Glu Asp Lys Asn Cys Gln Lys Ser Thr 
                165                 170                 175     


Ile Tyr Leu Val Arg Ser Gly Met Lys Gln Trp Val Pro Val Leu Gln 
            180                 185                 190         


Asp Phe Ser Asn Lys Gly Thr Leu Trp Gly Phe Val Pro Phe Val Asp 
        195                 200                 205             


Glu Gln Gln Pro Thr Glu Ile Pro Ile Pro Ile Thr Leu His Ile Gly 
    210                 215                 220                 


Asp Tyr Asn Met Asp Gly Tyr Pro Asp Ala Leu Val Ile Leu Lys Asn 
225                 230                 235                 240 


Thr Ser Gly Ser Asn Gln Gln Ala Phe Leu Leu Glu Asn Val Pro Cys 
                245                 250                 255     


Asn Asn Ala Ser Cys Glu Glu Ala Arg Arg Met Phe Lys Val Tyr Trp 
            260                 265                 270         


Glu Leu Thr Asp Leu Asn Gln Ile Lys Asp Ala Met Val Ala Thr Phe 
        275                 280                 285             


Phe Asp Ile Tyr Glu Asp Gly Ile Leu Asp Ile Val Val Leu Ser Lys 
    290                 295                 300                 


Gly Tyr Thr Lys Asn Asp Phe Ala Ile His Thr Leu Lys Asn Asn Phe 
305                 310                 315                 320 


Glu Ala Asp Ala Tyr Phe Val Lys Val Ile Val Leu Ser Gly Leu Cys 
                325                 330                 335     


Ser Asn Asp Cys Pro Arg Lys Ile Thr Pro Phe Gly Val Asn Gln Pro 
            340                 345                 350         


Gly Pro Tyr Ile Met Tyr Thr Thr Val Asp Ala Asn Gly Tyr Leu Lys 
        355                 360                 365             


Asn Gly Ser Ala Gly Gln Leu Ser Gln Ser Ala His Leu Ala Leu Gln 
    370                 375                 380                 


Leu Pro Tyr Asn Val Leu Gly Leu Gly Arg Ser Ala Asn Phe Leu Asp 
385                 390                 395                 400 


His Leu Tyr Val Gly Ile Pro Arg Pro Ser Gly Glu Lys Ser Ile Arg 
                405                 410                 415     


Lys Gln Glu Trp Thr Ala Ile Ile Pro Asn Ser Gln Leu Ile Val Ile 
            420                 425                 430         


Pro Tyr Pro His Asn Val Pro Arg Ser Ser His Arg Cys Leu Cys Phe 
        435                 440                 445             


His Leu Gly Asn Asn Trp His Phe Thr Leu Ala Gly Lys Glu Ser Arg 
    450                 455                 460                 


<210>  5604
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITFG3__Homo_sapiens__NP_114428

<400>  5604

Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn 
1               5                   10                  15      


Glu Glu Arg Lys Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu 
            20                  25                  30          


Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg 
        35                  40                  45              


Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe 
    50                  55                  60                  


Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg 
65                  70                  75                  80  


Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala 
                85                  90                  95      


Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr 
            100                 105                 110         


Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu 
        115                 120                 125             


Gly Phe Ser Ser Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn 
    130                 135                 140                 


Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val 
145                 150                 155                 160 


Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys 
                165                 170                 175     


Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr 
            180                 185                 190         


Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser 
        195                 200                 205             


Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala 
    210                 215                 220                 


Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His 
225                 230                 235                 240 


Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu 
                245                 250                 255     


Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly 
            260                 265                 270         


Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser 
        275                 280                 285             


Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys 
    290                 295                 300                 


Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met 
305                 310                 315                 320 


Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly 
                325                 330                 335     


Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu 
            340                 345                 350         


Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His 
        355                 360                 365             


Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala 
    370                 375                 380                 


Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu 
385                 390                 395                 400 


Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu 
                405                 410                 415     


Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser 
            420                 425                 430         


Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr 
        435                 440                 445             


Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu 
    450                 455                 460                 


Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala 
465                 470                 475                 480 


Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu 
                485                 490                 495     


Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile 
            500                 505                 510         


Lys His Lys Val Arg Asp Leu Val Pro Ser Ser Arg Val Val Arg Leu 
        515                 520                 525             


Gly Glu Gly Gly Pro Asp Ser Asp Gln Ala Ile Arg Asp Arg Phe Ser 
    530                 535                 540                 


Arg Leu Arg Tyr Gln Ser Glu Ala 
545                 550         


<210>  5605
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA10__Homo_sapiens__NP_001289969

<400>  5605

Met Asn Ile Thr His Ala Tyr Ser Gln Gly His Gln Lys Leu Asn Leu 
1               5                   10                  15      


Asp Thr Val Ser Tyr Asn Met Leu Gly Val Asp Ser Asp Gly Cys Pro 
            20                  25                  30          


Thr Tyr Met Asp Val Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr 
        35                  40                  45              


Pro Trp Ser Glu Val Gln Thr Phe Leu Arg Arg Leu Val Gly Lys Leu 
    50                  55                  60                  


Phe Ile Asp Pro Glu Gln Ile Gln Val Gly Leu Val Gln Tyr Gly Glu 
65                  70                  75                  80  


Ser Pro Val His Glu Trp Ser Leu Gly Asp Phe Arg Thr Lys Glu Glu 
                85                  90                  95      


Val Val Arg Ala Ala Lys Asn Leu Ser Arg Arg Glu Gly Arg Glu Thr 
            100                 105                 110         


Lys Thr Ala Gln Ala Ile Met Val Ala Cys Thr Glu Gly Phe Ser Gln 
        115                 120                 125             


Ser His Gly Gly Arg Pro Glu Ala Ala Arg Leu Leu Val Val Val Thr 
    130                 135                 140                 


Asp Gly Glu Ser His Asp Gly Glu Glu Leu Pro Ala Ala Leu Lys Ala 
145                 150                 155                 160 


Cys Glu Ala Gly Arg Val Thr Arg Tyr Gly Ile Ala Val Leu Gly His 
                165                 170                 175     


Tyr Leu Arg Arg Gln Arg Asp Pro Ser Ser Phe Leu Arg Glu Ile Arg 
            180                 185                 190         


Thr Ile Ala Ser Asp Pro Asp Glu Arg Phe Phe Phe Asn Val Thr Asp 
        195                 200                 205             


Glu Ala Ala Leu Thr Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe 
    210                 215                 220                 


Gly Leu Glu Gly Ser His Ala Glu Asn Glu Ser Ser Phe Gly Leu Glu 
225                 230                 235                 240 


Met Ser Gln Ile Gly Phe Ser Thr His Arg Leu Lys Asp Gly Ile Leu 
                245                 250                 255     


Phe Gly Met Val Gly Ala Tyr Asp Trp Gly Gly Ser Val Leu Trp Leu 
            260                 265                 270         


Glu Gly Gly His Arg Leu Phe Pro Pro Arg Met Ala Leu Glu Asp Glu 
        275                 280                 285             


Phe Pro Pro Ala Leu Gln Asn His Ala Ala Tyr Leu Gly Tyr Ser Val 
    290                 295                 300                 


Ser Ser Met Leu Leu Arg Gly Gly Arg Arg Leu Phe Leu Ser Gly Ala 
305                 310                 315                 320 


Pro Arg Phe Arg His Arg Gly Lys Val Ile Ala Phe Gln Leu Lys Lys 
                325                 330                 335     


Asp Gly Ala Val Arg Val Ala Gln Ser Leu Gln Gly Glu Gln Ile Gly 
            340                 345                 350         


Ser Tyr Phe Gly Ser Glu Leu Cys Pro Leu Asp Thr Asp Arg Asp Gly 
        355                 360                 365             


Thr Thr Asp Val Leu Leu Val Ala Ala Pro Met Phe Leu Gly Pro Gln 
    370                 375                 380                 


Asn Lys Glu Thr Gly Arg Val Tyr Val Tyr Leu Val Gly Gln Gln Ser 
385                 390                 395                 400 


Leu Leu Thr Leu Gln Gly Thr Leu Gln Pro Glu Pro Pro Gln Asp Ala 
                405                 410                 415     


Arg Phe Gly Phe Ala Met Gly Ala Leu Pro Asp Leu Asn Gln Asp Gly 
            420                 425                 430         


Phe Ala Asp Val Ala Val Gly Ala Pro Leu Glu Asp Gly His Gln Gly 
        435                 440                 445             


Ala Leu Tyr Leu Tyr His Gly Thr Gln Ser Gly Val Arg Pro His Pro 
    450                 455                 460                 


Ala Gln Arg Ile Ala Ala Ala Ser Met Pro His Ala Leu Ser Tyr Phe 
465                 470                 475                 480 


Gly Arg Ser Val Asp Gly Arg Leu Asp Leu Asp Gly Asp Asp Leu Val 
                485                 490                 495     


Asp Val Ala Val Gly Ala Gln Gly Ala Ala Ile Leu Leu Ser Ser Arg 
            500                 505                 510         


Pro Ile Val His Leu Thr Pro Ser Leu Glu Val Thr Pro Gln Ala Ile 
        515                 520                 525             


Ser Val Val Gln Arg Asp Cys Arg Arg Arg Gly Gln Glu Ala Val Cys 
    530                 535                 540                 


Leu Thr Ala Ala Leu Cys Phe Gln Val Thr Ser Arg Thr Pro Gly Arg 
545                 550                 555                 560 


Trp Asp His Gln Phe Tyr Met Arg Phe Thr Ala Ser Leu Asp Glu Trp 
                565                 570                 575     


Thr Ala Gly Ala Arg Ala Ala Phe Asp Gly Ser Gly Gln Arg Leu Ser 
            580                 585                 590         


Pro Arg Arg Leu Arg Leu Ser Val Gly Asn Val Thr Cys Glu Gln Leu 
        595                 600                 605             


His Phe His Val Leu Asp Thr Ser Asp Tyr Leu Arg Pro Val Ala Leu 
    610                 615                 620                 


Thr Val Thr Phe Ala Leu Asp Asn Thr Thr Lys Pro Gly Pro Val Leu 
625                 630                 635                 640 


Asn Glu Gly Ser Pro Thr Ser Ile Gln Lys Leu Val Pro Phe Ser Lys 
                645                 650                 655     


Asp Cys Gly Pro Asp Asn Glu Cys Val Thr Asp Leu Val Leu Gln Val 
            660                 665                 670         


Asn Met Asp Ile Arg Gly Ser Arg Lys Ala Pro Phe Val Val Arg Gly 
        675                 680                 685             


Gly Arg Arg Lys Val Leu Val Ser Thr Thr Leu Glu Asn Arg Lys Glu 
    690                 695                 700                 


Asn Ala Tyr Asn Thr Ser Leu Ser Leu Ile Phe Ser Arg Asn Leu His 
705                 710                 715                 720 


Leu Ala Ser Leu Thr Pro Gln Arg Glu Ser Pro Ile Lys Val Glu Cys 
                725                 730                 735     


Ala Ala Pro Ser Ala His Ala Arg Leu Cys Ser Val Gly His Pro Val 
            740                 745                 750         


Phe Gln Thr Gly Ala Lys Val Thr Phe Leu Leu Glu Phe Glu Phe Ser 
        755                 760                 765             


Cys Ser Ser Leu Leu Ser Gln Val Phe Val Lys Leu Thr Ala Ser Ser 
    770                 775                 780                 


Asp Ser Leu Glu Arg Asn Gly Thr Leu Gln Asp Asn Thr Ala Gln Thr 
785                 790                 795                 800 


Ser Ala Tyr Ile Gln Tyr Glu Pro His Leu Leu Phe Ser Ser Glu Ser 
                805                 810                 815     


Thr Leu His Arg Tyr Glu Val His Pro Tyr Gly Thr Leu Pro Val Gly 
            820                 825                 830         


Pro Gly Pro Glu Phe Lys Thr Thr Leu Arg Val Gln Asn Leu Gly Cys 
        835                 840                 845             


Tyr Val Val Ser Gly Leu Ile Ile Ser Ala Leu Leu Pro Ala Val Ala 
    850                 855                 860                 


His Gly Gly Asn Tyr Phe Leu Ser Leu Ser Gln Val Ile Thr Asn Asn 
865                 870                 875                 880 


Ala Ser Cys Ile Val Gln Asn Leu Thr Glu Pro Pro Gly Pro Pro Val 
                885                 890                 895     


His Pro Glu Glu Leu Gln His Thr Asn Arg Leu Asn Gly Ser Asn Thr 
            900                 905                 910         


Gln Cys Gln Val Val Arg Cys His Leu Gly Gln Leu Ala Lys Gly Thr 
        915                 920                 925             


Glu Val Ser Val Gly Leu Leu Arg Leu Val His Asn Glu Phe Phe Arg 
    930                 935                 940                 


Arg Ala Lys Phe Lys Ser Leu Thr Val Val Ser Thr Phe Glu Leu Gly 
945                 950                 955                 960 


Thr Glu Glu Gly Ser Val Leu Gln Leu Thr Glu Ala Ser Arg Trp Ser 
                965                 970                 975     


Glu Ser Leu Leu Glu Val Val Gln Thr Arg Pro Ile Leu Ile Ser Leu 
            980                 985                 990         


Trp Ile Leu Ile Gly Ser Val Leu  Gly Gly Leu Leu Leu  Leu Ala Leu 
        995                 1000                 1005             


Leu Val  Phe Cys Leu Trp Lys  Leu Gly Phe Phe Ala  His Lys Lys 
    1010                 1015                 1020             


Ile Pro  Glu Glu Glu Lys Arg  Glu Glu Lys Leu Glu  Gln 
    1025                 1030                 1035     


<210>  5606
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA11__Homo_sapiens__NP_001004439

<400>  5606

Met Asp Leu Pro Arg Gly Leu Val Val Ala Trp Ala Leu Ser Leu Trp 
1               5                   10                  15      


Pro Gly Phe Thr Asp Thr Phe Asn Met Asp Thr Arg Lys Pro Arg Val 
            20                  25                  30          


Ile Pro Gly Ser Arg Thr Ala Phe Phe Gly Tyr Thr Val Gln Gln His 
        35                  40                  45              


Asp Ile Ser Gly Asn Lys Trp Leu Val Val Gly Ala Pro Leu Glu Thr 
    50                  55                  60                  


Asn Gly Tyr Gln Lys Thr Gly Asp Val Tyr Lys Cys Pro Val Ile His 
65                  70                  75                  80  


Gly Asn Cys Thr Lys Leu Asn Leu Gly Arg Val Thr Leu Ser Asn Val 
                85                  90                  95      


Ser Glu Arg Lys Asp Asn Met Arg Leu Gly Leu Ser Leu Ala Thr Asn 
            100                 105                 110         


Pro Lys Asp Asn Ser Phe Leu Ala Cys Ser Pro Leu Trp Ser His Glu 
        115                 120                 125             


Cys Gly Ser Ser Tyr Tyr Thr Thr Gly Met Cys Ser Arg Val Asn Ser 
    130                 135                 140                 


Asn Phe Arg Phe Ser Lys Thr Val Ala Pro Ala Leu Gln Arg Cys Gln 
145                 150                 155                 160 


Thr Tyr Met Asp Ile Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr 
                165                 170                 175     


Pro Trp Val Glu Val Gln His Phe Leu Ile Asn Ile Leu Lys Lys Phe 
            180                 185                 190         


Tyr Ile Gly Pro Gly Gln Ile Gln Val Gly Val Val Gln Tyr Gly Glu 
        195                 200                 205             


Asp Val Val His Glu Phe His Leu Asn Asp Tyr Arg Ser Val Lys Asp 
    210                 215                 220                 


Val Val Glu Ala Ala Ser His Ile Glu Gln Arg Gly Gly Thr Glu Thr 
225                 230                 235                 240 


Arg Thr Ala Phe Gly Ile Glu Phe Ala Arg Ser Glu Ala Phe Gln Lys 
                245                 250                 255     


Gly Gly Arg Lys Gly Ala Lys Lys Val Met Ile Val Ile Thr Asp Gly 
            260                 265                 270         


Glu Ser His Asp Ser Pro Asp Leu Glu Lys Val Ile Gln Gln Ser Glu 
        275                 280                 285             


Arg Asp Asn Val Thr Arg Tyr Ala Val Ala Val Leu Gly Tyr Tyr Asn 
    290                 295                 300                 


Arg Arg Gly Ile Asn Pro Glu Thr Phe Leu Asn Glu Ile Lys Tyr Ile 
305                 310                 315                 320 


Ala Ser Asp Pro Asp Asp Lys His Phe Phe Asn Val Thr Asp Glu Ala 
                325                 330                 335     


Ala Leu Lys Asp Ile Val Asp Ala Leu Gly Asp Arg Ile Phe Ser Leu 
            340                 345                 350         


Glu Gly Thr Asn Lys Asn Glu Thr Ser Phe Gly Leu Glu Met Ser Gln 
        355                 360                 365             


Thr Gly Phe Ser Ser His Val Val Glu Asp Gly Val Leu Leu Gly Ala 
    370                 375                 380                 


Val Gly Ala Tyr Asp Trp Asn Gly Ala Val Leu Lys Glu Thr Ser Ala 
385                 390                 395                 400 


Gly Lys Val Ile Pro Leu Arg Glu Ser Tyr Leu Lys Glu Phe Pro Glu 
                405                 410                 415     


Glu Leu Lys Asn His Gly Ala Tyr Leu Gly Tyr Thr Val Thr Ser Val 
            420                 425                 430         


Val Ser Ser Arg Gln Gly Arg Val Tyr Val Ala Gly Ala Pro Arg Phe 
        435                 440                 445             


Asn His Thr Gly Lys Val Ile Leu Phe Thr Met His Asn Asn Arg Ser 
    450                 455                 460                 


Leu Thr Ile His Gln Ala Met Arg Gly Gln Gln Ile Gly Ser Tyr Phe 
465                 470                 475                 480 


Gly Ser Glu Ile Thr Ser Val Asp Ile Asp Gly Asp Gly Val Thr Asp 
                485                 490                 495     


Val Leu Leu Val Gly Ala Pro Met Tyr Phe Asn Glu Gly Arg Glu Arg 
            500                 505                 510         


Gly Lys Val Tyr Val Tyr Glu Leu Arg Gln Asn Leu Phe Val Tyr Asn 
        515                 520                 525             


Gly Thr Leu Lys Asp Ser His Ser Tyr Gln Asn Ala Arg Phe Gly Ser 
    530                 535                 540                 


Ser Ile Ala Ser Val Arg Asp Leu Asn Gln Asp Ser Tyr Asn Asp Val 
545                 550                 555                 560 


Val Val Gly Ala Pro Leu Glu Asp Asn His Ala Gly Ala Ile Tyr Ile 
                565                 570                 575     


Phe His Gly Phe Arg Gly Ser Ile Leu Lys Thr Pro Lys Gln Arg Ile 
            580                 585                 590         


Thr Ala Ser Glu Leu Ala Thr Gly Leu Gln Tyr Phe Gly Cys Ser Ile 
        595                 600                 605             


His Gly Gln Leu Asp Leu Asn Glu Asp Gly Leu Ile Asp Leu Ala Val 
    610                 615                 620                 


Gly Ala Leu Gly Asn Ala Val Ile Leu Trp Ser Arg Pro Val Val Gln 
625                 630                 635                 640 


Ile Asn Ala Ser Leu His Phe Glu Pro Ser Lys Ile Asn Ile Phe His 
                645                 650                 655     


Arg Asp Cys Lys Arg Ser Gly Arg Asp Ala Thr Cys Leu Ala Ala Phe 
            660                 665                 670         


Leu Cys Phe Thr Pro Ile Phe Leu Ala Pro His Phe Gln Thr Thr Thr 
        675                 680                 685             


Val Gly Ile Arg Tyr Asn Ala Thr Met Asp Glu Arg Arg Tyr Thr Pro 
    690                 695                 700                 


Arg Ala His Leu Asp Glu Gly Gly Asp Arg Phe Thr Asn Arg Ala Val 
705                 710                 715                 720 


Leu Leu Ser Ser Gly Gln Glu Leu Cys Glu Arg Ile Asn Phe His Val 
                725                 730                 735     


Leu Asp Thr Ala Asp Tyr Val Lys Pro Val Thr Phe Ser Val Glu Tyr 
            740                 745                 750         


Ser Leu Glu Asp Pro Asp His Gly Pro Met Leu Asp Asp Gly Trp Pro 
        755                 760                 765             


Thr Thr Leu Arg Val Ser Val Pro Phe Trp Asn Gly Cys Asn Glu Asp 
    770                 775                 780                 


Glu His Cys Val Pro Asp Leu Val Leu Asp Ala Arg Ser Asp Leu Pro 
785                 790                 795                 800 


Thr Ala Met Glu Tyr Cys Gln Arg Val Leu Arg Lys Pro Ala Gln Asp 
                805                 810                 815     


Cys Ser Ala Tyr Thr Leu Ser Phe Asp Thr Thr Val Phe Ile Ile Glu 
            820                 825                 830         


Ser Thr Arg Gln Arg Val Ala Val Glu Ala Thr Leu Glu Asn Arg Gly 
        835                 840                 845             


Glu Asn Ala Tyr Ser Thr Val Leu Asn Ile Ser Gln Ser Ala Asn Leu 
    850                 855                 860                 


Gln Phe Ala Ser Leu Ile Gln Lys Glu Asp Ser Asp Gly Ser Ile Glu 
865                 870                 875                 880 


Cys Val Asn Glu Glu Arg Arg Leu Gln Lys Gln Val Cys Asn Val Ser 
                885                 890                 895     


Tyr Pro Phe Phe Arg Ala Lys Ala Lys Val Ala Phe Arg Leu Asp Phe 
            900                 905                 910         


Glu Phe Ser Lys Ser Ile Phe Leu His His Leu Glu Ile Glu Leu Ala 
        915                 920                 925             


Ala Gly Ser Asp Ser Asn Glu Arg Asp Ser Thr Lys Glu Asp Asn Val 
    930                 935                 940                 


Ala Pro Leu Arg Phe His Leu Lys Tyr Glu Ala Asp Val Leu Phe Thr 
945                 950                 955                 960 


Arg Ser Ser Ser Leu Ser His Tyr Glu Val Lys Pro Asn Ser Ser Leu 
                965                 970                 975     


Glu Arg Tyr Asp Gly Ile Gly Pro Pro Phe Ser Cys Ile Phe Arg Ile 
            980                 985                 990         


Gln Asn Leu Gly Leu Phe Pro Ile  His Gly Met Met Met  Lys Ile Thr 
        995                 1000                 1005             


Ile Pro  Ile Ala Thr Arg Ser  Gly Asn Arg Leu Leu  Lys Leu Arg 
    1010                 1015                 1020             


Asp Phe  Leu Thr Asp Glu Ala  Asn Thr Ser Cys Asn  Ile Trp Gly 
    1025                 1030                 1035             


Asn Ser  Thr Glu Tyr Arg Pro  Thr Pro Val Glu Glu  Asp Leu Arg 
    1040                 1045                 1050             


Arg Ala  Pro Gln Leu Asn His  Ser Asn Ser Asp Val  Val Ser Ile 
    1055                 1060                 1065             


Asn Cys  Asn Ile Arg Leu Val  Pro Asn Gln Glu Ile  Asn Phe His 
    1070                 1075                 1080             


Leu Leu  Gly Asn Leu Trp Leu  Arg Ser Leu Lys Ala  Leu Lys Tyr 
    1085                 1090                 1095             


Lys Ser  Met Lys Ile Met Val  Asn Ala Ala Leu Gln  Arg Gln Phe 
    1100                 1105                 1110             


His Ser  Pro Phe Ile Phe Arg  Glu Glu Asp Pro Ser  Arg Gln Ile 
    1115                 1120                 1125             


Val Phe  Glu Ile Ser Lys Gln  Glu Asp Trp Gln Val  Pro Ile Trp 
    1130                 1135                 1140             


Ile Ile  Val Gly Ser Thr Leu  Gly Gly Leu Leu Leu  Leu Ala Leu 
    1145                 1150                 1155             


Leu Val  Leu Ala Leu Trp Lys  Leu Gly Phe Phe Arg  Ser Ala Arg 
    1160                 1165                 1170             


Arg Arg  Arg Glu Pro Gly Leu  Asp Pro Thr Pro Lys  Val Leu Glu 
    1175                 1180                 1185             


<210>  5607
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA1__Homo_sapiens__NP_852478

<400>  5607

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15      


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30          


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45              


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60                  


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80  


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95      


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110         


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125             


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140                 


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160 


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175     


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190         


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205             


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220                 


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240 


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255     


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270         


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285             


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300                 


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320 


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335     


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350         


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365             


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380                 


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400 


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415     


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430         


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445             


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460                 


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480 


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495     


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510         


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525             


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540                 


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560 


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575     


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590         


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605             


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620                 


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640 


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655     


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670         


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685             


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700                 


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720 


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735     


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750         


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp 
        755                 760                 765             


Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro 
    770                 775                 780                 


Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu 
785                 790                 795                 800 


Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser 
                805                 810                 815     


Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val 
            820                 825                 830         


Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr 
        835                 840                 845             


Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn 
    850                 855                 860                 


Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser 
865                 870                 875                 880 


Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly 
                885                 890                 895     


Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu 
            900                 905                 910         


Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu 
        915                 920                 925             


Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val 
    930                 935                 940                 


Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His 
945                 950                 955                 960 


Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr 
                965                 970                 975     


Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser 
            980                 985                 990         


Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn 
        995                 1000                 1005             


Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser 
    1010                 1015                 1020             


Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro 
    1025                 1030                 1035             


Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His 
    1040                 1045                 1050             


Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala 
    1055                 1060                 1065             


Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn 
    1070                 1075                 1080             


Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe 
    1085                 1090                 1095             


Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn 
    1100                 1105                 1110             


Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala 
    1115                 1120                 1125             


Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp 
    1130                 1135                 1140             


Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu 
    1145                 1150                 1155             


Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu 
    1160                 1165                 1170             


Lys Lys  Lys Met Glu Lys 
    1175                 


<210>  5608
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA2B__Homo_sapiens__NP_000410

<400>  5608

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
            20                  25                  30          


Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
        35                  40                  45              


Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
    50                  55                  60                  


Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
65                  70                  75                  80  


Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                85                  90                  95      


Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
            100                 105                 110         


Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
        115                 120                 125             


Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
    130                 135                 140                 


Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
145                 150                 155                 160 


Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                165                 170                 175     


Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
            180                 185                 190         


Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
        195                 200                 205             


Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
225                 230                 235                 240 


Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                245                 250                 255     


Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
            260                 265                 270         


Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
        275                 280                 285             


Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
    290                 295                 300                 


Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 
305                 310                 315                 320 


Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                325                 330                 335     


Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
            340                 345                 350         


Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
        355                 360                 365             


His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
    370                 375                 380                 


Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
385                 390                 395                 400 


Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                405                 410                 415     


Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
            420                 425                 430         


Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
        435                 440                 445             


Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
    450                 455                 460                 


Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
465                 470                 475                 480 


Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                485                 490                 495     


Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
            500                 505                 510         


Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
        515                 520                 525             


Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
    530                 535                 540                 


Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
545                 550                 555                 560 


Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                565                 570                 575     


His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
            580                 585                 590         


Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
        595                 600                 605             


Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
    610                 615                 620                 


Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
625                 630                 635                 640 


Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                645                 650                 655     


Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
            660                 665                 670         


Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
        675                 680                 685             


His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
    690                 695                 700                 


Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
705                 710                 715                 720 


Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                725                 730                 735     


Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
            740                 745                 750         


Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
        755                 760                 765             


Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
    770                 775                 780                 


Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
785                 790                 795                 800 


Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                805                 810                 815     


Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
            820                 825                 830         


His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
        835                 840                 845             


Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
    850                 855                 860                 


Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
865                 870                 875                 880 


His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                885                 890                 895     


Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
            900                 905                 910         


Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
        915                 920                 925             


Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
    930                 935                 940                 


Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
945                 950                 955                 960 


Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                965                 970                 975     


Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
            980                 985                 990         


Arg Ala Ile Pro Ile Trp Trp Val  Leu Val Gly Val Leu  Gly Gly Leu 
        995                 1000                 1005             


Leu Leu  Leu Thr Ile Leu Val  Leu Ala Met Trp Lys  Val Gly Phe 
    1010                 1015                 1020             


Phe Lys  Arg Asn Arg Pro Pro  Leu Glu Glu Asp Asp  Glu Glu Gly 
    1025                 1030                 1035             


Glu 
    


<210>  5609
<211>  1181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA2__Homo_sapiens__NP_002194

<400>  5609

Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          


Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              


Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  


Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  


Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      


Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         


Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             


Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 


Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 


Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     


Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         


Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             


Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 


Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 


Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     


Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         


Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             


Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 


Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 


Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     


Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         


Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             


Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 


Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 


Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     


Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         


His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             


Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 


Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 


Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     


Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         


Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             


Leu Phe Thr Ile Lys Glu Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 


Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 


Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     


Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         


Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             


Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 


Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 


Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     


Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         


Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             


Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 


Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 


Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     


Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         


Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             


Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 


Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 


Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     


Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         


Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             


Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 


Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 


Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     


Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         


Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             


Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 


Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 


Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     


Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         


Ile Pro Gln Tyr Thr Lys Glu Lys  Asn Pro Leu Met Tyr  Leu Thr Gly 
        995                 1000                 1005             


Val Gln  Thr Asp Lys Ala Gly  Asp Ile Ser Cys Asn  Ala Asp Ile 
    1010                 1015                 1020             


Asn Pro  Leu Lys Ile Gly Gln  Thr Ser Ser Ser Val  Ser Phe Lys 
    1025                 1030                 1035             


Ser Glu  Asn Phe Arg His Thr  Lys Glu Leu Asn Cys  Arg Thr Ala 
    1040                 1045                 1050             


Ser Cys  Ser Asn Val Thr Cys  Trp Leu Lys Asp Val  His Met Lys 
    1055                 1060                 1065             


Gly Glu  Tyr Phe Val Asn Val  Thr Thr Arg Ile Trp  Asn Gly Thr 
    1070                 1075                 1080             


Phe Ala  Ser Ser Thr Phe Gln  Thr Val Gln Leu Thr  Ala Ala Ala 
    1085                 1090                 1095             


Glu Ile  Asn Thr Tyr Asn Pro  Glu Ile Tyr Val Ile  Glu Asp Asn 
    1100                 1105                 1110             


Thr Val  Thr Ile Pro Leu Met  Ile Met Lys Pro Asp  Glu Lys Ala 
    1115                 1120                 1125             


Glu Val  Pro Thr Gly Val Ile  Ile Gly Ser Ile Ile  Ala Gly Ile 
    1130                 1135                 1140             


Leu Leu  Leu Leu Ala Leu Val  Ala Ile Leu Trp Lys  Leu Gly Phe 
    1145                 1150                 1155             


Phe Lys  Arg Lys Tyr Glu Lys  Met Thr Lys Asn Pro  Asp Glu Ile 
    1160                 1165                 1170             


Asp Glu  Thr Thr Glu Leu Ser  Ser 
    1175                 1180     


<210>  5610
<211>  1051
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA3__Homo_sapiens__NP_002195

<400>  5610

Met Gly Pro Gly Pro Ser Arg Ala Pro Arg Ala Pro Arg Leu Met Leu 
1               5                   10                  15      


Cys Ala Leu Ala Leu Met Val Ala Ala Gly Gly Cys Val Val Ser Ala 
            20                  25                  30          


Phe Asn Leu Asp Thr Arg Phe Leu Val Val Lys Glu Ala Gly Asn Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Tyr Ser Val Ala Leu His Arg Gln Thr Glu Arg 
    50                  55                  60                  


Gln Gln Arg Tyr Leu Leu Leu Ala Gly Ala Pro Arg Glu Leu Ala Val 
65                  70                  75                  80  


Pro Asp Gly Tyr Thr Asn Arg Thr Gly Ala Val Tyr Leu Cys Pro Leu 
                85                  90                  95      


Thr Ala His Lys Asp Asp Cys Glu Arg Met Asn Ile Thr Val Lys Asn 
            100                 105                 110         


Asp Pro Gly His His Ile Ile Glu Asp Met Trp Leu Gly Val Thr Val 
        115                 120                 125             


Ala Ser Gln Gly Pro Ala Gly Arg Val Leu Val Cys Ala His Arg Tyr 
    130                 135                 140                 


Thr Gln Val Leu Trp Ser Gly Ser Glu Asp Gln Arg Arg Met Val Gly 
145                 150                 155                 160 


Lys Cys Tyr Val Arg Gly Asn Asp Leu Glu Leu Asp Ser Ser Asp Asp 
                165                 170                 175     


Trp Gln Thr Tyr His Asn Glu Met Cys Asn Ser Asn Thr Asp Tyr Leu 
            180                 185                 190         


Glu Thr Gly Met Cys Gln Leu Gly Thr Ser Gly Gly Phe Thr Gln Asn 
        195                 200                 205             


Thr Val Tyr Phe Gly Ala Pro Gly Ala Tyr Asn Trp Lys Gly Asn Ser 
    210                 215                 220                 


Tyr Met Ile Gln Arg Lys Glu Trp Asp Leu Ser Glu Tyr Ser Tyr Lys 
225                 230                 235                 240 


Asp Pro Glu Asp Gln Gly Asn Leu Tyr Ile Gly Tyr Thr Met Gln Val 
                245                 250                 255     


Gly Ser Phe Ile Leu His Pro Lys Asn Ile Thr Ile Val Thr Gly Ala 
            260                 265                 270         


Pro Arg His Arg His Met Gly Ala Val Phe Leu Leu Ser Gln Glu Ala 
        275                 280                 285             


Gly Gly Asp Leu Arg Arg Arg Gln Val Leu Glu Gly Ser Gln Val Gly 
    290                 295                 300                 


Ala Tyr Phe Gly Ser Ala Ile Ala Leu Ala Asp Leu Asn Asn Asp Gly 
305                 310                 315                 320 


Trp Gln Asp Leu Leu Val Gly Ala Pro Tyr Tyr Phe Glu Arg Lys Glu 
                325                 330                 335     


Glu Val Gly Gly Ala Ile Tyr Val Phe Met Asn Gln Ala Gly Thr Ser 
            340                 345                 350         


Phe Pro Ala His Pro Ser Leu Leu Leu His Gly Pro Ser Gly Ser Ala 
        355                 360                 365             


Phe Gly Leu Ser Val Ala Ser Ile Gly Asp Ile Asn Gln Asp Gly Phe 
    370                 375                 380                 


Gln Asp Ile Ala Val Gly Ala Pro Phe Glu Gly Leu Gly Lys Val Tyr 
385                 390                 395                 400 


Ile Tyr His Ser Ser Ser Lys Gly Leu Leu Arg Gln Pro Gln Gln Val 
                405                 410                 415     


Ile His Gly Glu Lys Leu Gly Leu Pro Gly Leu Ala Thr Phe Gly Tyr 
            420                 425                 430         


Ser Leu Ser Gly Gln Met Asp Val Asp Glu Asn Phe Tyr Pro Asp Leu 
        435                 440                 445             


Leu Val Gly Ser Leu Ser Asp His Ile Val Leu Leu Arg Ala Arg Pro 
    450                 455                 460                 


Val Ile Asn Ile Val His Lys Thr Leu Val Pro Arg Pro Ala Val Leu 
465                 470                 475                 480 


Asp Pro Ala Leu Cys Thr Ala Thr Ser Cys Val Gln Val Glu Leu Cys 
                485                 490                 495     


Phe Ala Tyr Asn Gln Ser Ala Gly Asn Pro Asn Tyr Arg Arg Asn Ile 
            500                 505                 510         


Thr Leu Ala Tyr Thr Leu Glu Ala Asp Arg Asp Arg Arg Pro Pro Arg 
        515                 520                 525             


Leu Arg Phe Ala Gly Ser Glu Ser Ala Val Phe His Gly Phe Phe Ser 
    530                 535                 540                 


Met Pro Glu Met Arg Cys Gln Lys Leu Glu Leu Leu Leu Met Asp Asn 
545                 550                 555                 560 


Leu Arg Asp Lys Leu Arg Pro Ile Ile Ile Ser Met Asn Tyr Ser Leu 
                565                 570                 575     


Pro Leu Arg Met Pro Asp Arg Pro Arg Leu Gly Leu Arg Ser Leu Asp 
            580                 585                 590         


Ala Tyr Pro Ile Leu Asn Gln Ala Gln Ala Leu Glu Asn His Thr Glu 
        595                 600                 605             


Val Gln Phe Gln Lys Glu Cys Gly Pro Asp Asn Lys Cys Glu Ser Asn 
    610                 615                 620                 


Leu Gln Met Arg Ala Ala Phe Val Ser Glu Gln Gln Gln Lys Leu Ser 
625                 630                 635                 640 


Arg Leu Gln Tyr Ser Arg Asp Val Arg Lys Leu Leu Leu Ser Ile Asn 
                645                 650                 655     


Val Thr Asn Thr Arg Thr Ser Glu Arg Ser Gly Glu Asp Ala His Glu 
            660                 665                 670         


Ala Leu Leu Thr Leu Val Val Pro Pro Ala Leu Leu Leu Ser Ser Val 
        675                 680                 685             


Arg Pro Pro Gly Ala Cys Gln Ala Asn Glu Thr Ile Phe Cys Glu Leu 
    690                 695                 700                 


Gly Asn Pro Phe Lys Arg Asn Gln Arg Met Glu Leu Leu Ile Ala Phe 
705                 710                 715                 720 


Glu Val Ile Gly Val Thr Leu His Thr Arg Asp Leu Gln Val Gln Leu 
                725                 730                 735     


Gln Leu Ser Thr Ser Ser His Gln Asp Asn Leu Trp Pro Met Ile Leu 
            740                 745                 750         


Thr Leu Leu Val Asp Tyr Thr Leu Gln Thr Ser Leu Ser Met Val Asn 
        755                 760                 765             


His Arg Leu Gln Ser Phe Phe Gly Gly Thr Val Met Gly Glu Ser Gly 
    770                 775                 780                 


Met Lys Thr Val Glu Asp Val Gly Ser Pro Leu Lys Tyr Glu Phe Gln 
785                 790                 795                 800 


Val Gly Pro Met Gly Glu Gly Leu Val Gly Leu Gly Thr Leu Val Leu 
                805                 810                 815     


Gly Leu Glu Trp Pro Tyr Glu Val Ser Asn Gly Lys Trp Leu Leu Tyr 
            820                 825                 830         


Pro Thr Glu Ile Thr Val His Gly Asn Gly Ser Trp Pro Cys Arg Pro 
        835                 840                 845             


Pro Gly Asp Leu Ile Asn Pro Leu Asn Leu Thr Leu Ser Asp Pro Gly 
    850                 855                 860                 


Asp Arg Pro Ser Ser Pro Gln Arg Arg Arg Arg Gln Leu Asp Pro Gly 
865                 870                 875                 880 


Gly Gly Gln Gly Pro Pro Pro Val Thr Leu Ala Ala Ala Lys Lys Ala 
                885                 890                 895     


Lys Ser Glu Thr Val Leu Thr Cys Ala Thr Gly Arg Ala His Cys Val 
            900                 905                 910         


Trp Leu Glu Cys Pro Ile Pro Asp Ala Pro Val Val Thr Asn Val Thr 
        915                 920                 925             


Val Lys Ala Arg Val Trp Asn Ser Thr Phe Ile Glu Asp Tyr Arg Asp 
    930                 935                 940                 


Phe Asp Arg Val Arg Val Asn Gly Trp Ala Thr Leu Phe Leu Arg Thr 
945                 950                 955                 960 


Ser Ile Pro Thr Ile Asn Met Glu Asn Lys Thr Thr Trp Phe Ser Val 
                965                 970                 975     


Asp Ile Asp Ser Glu Leu Val Glu Glu Leu Pro Ala Glu Ile Glu Leu 
            980                 985                 990         


Trp Leu Val Leu Val Ala Val Gly  Ala Gly Leu Leu Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Ile  Leu Leu Leu Trp Lys  Cys Gly Phe Phe Lys  Arg Ala Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Tyr Glu Ala  Lys Arg Gln Lys Ala  Glu Met Lys 
    1025                 1030                 1035             


Ser Gln  Pro Ser Glu Thr Glu  Arg Leu Thr Asp Asp  Tyr 
    1040                 1045                 1050     


<210>  5611
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA4__Homo_sapiens__NP_000876

<400>  5611

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  5612
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA5__Homo_sapiens__NP_002196

<400>  5612

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210>  5613
<211>  1073
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA6__Homo_sapiens__NP_000201

<400>  5613

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Asn  Lys Lys Asp His Tyr  Asp Ala Thr 
    1040                 1045                 1050             


Tyr His  Lys Ala Glu Ile His  Ala Gln Pro Ser Asp  Lys Glu Arg 
    1055                 1060                 1065             


Leu Thr  Ser Asp Ala 
    1070             


<210>  5614
<211>  1141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA7__Homo_sapiens__NP_001138468

<400>  5614

Met Ala Gly Ala Arg Ser Arg Asp Pro Trp Gly Ala Ser Gly Ile Cys 
1               5                   10                  15      


Tyr Leu Phe Gly Ser Leu Leu Val Glu Leu Leu Phe Ser Arg Ala Val 
            20                  25                  30          


Ala Phe Asn Leu Asp Val Met Gly Ala Leu Arg Lys Glu Gly Glu Pro 
        35                  40                  45              


Gly Ser Leu Phe Gly Phe Ser Val Ala Leu His Arg Gln Leu Gln Pro 
    50                  55                  60                  


Arg Pro Gln Ser Trp Leu Leu Val Gly Ala Pro Gln Ala Leu Ala Leu 
65                  70                  75                  80  


Pro Gly Gln Gln Ala Asn Arg Thr Gly Gly Leu Phe Ala Cys Pro Leu 
                85                  90                  95      


Ser Leu Glu Glu Thr Asp Cys Tyr Arg Val Asp Ile Asp Gln Gly Ala 
            100                 105                 110         


Asp Met Gln Lys Glu Ser Lys Glu Asn Gln Trp Leu Gly Val Ser Val 
        115                 120                 125             


Arg Ser Gln Gly Pro Gly Gly Lys Ile Val Thr Cys Ala His Arg Tyr 
    130                 135                 140                 


Glu Ala Arg Gln Arg Val Asp Gln Ile Leu Glu Thr Arg Asp Met Ile 
145                 150                 155                 160 


Gly Arg Cys Phe Val Leu Ser Gln Asp Leu Ala Ile Arg Asp Glu Leu 
                165                 170                 175     


Asp Gly Gly Glu Trp Lys Phe Cys Glu Gly Arg Pro Gln Gly His Glu 
            180                 185                 190         


Gln Phe Gly Phe Cys Gln Gln Gly Thr Ala Ala Ala Phe Ser Pro Asp 
        195                 200                 205             


Ser His Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly 
    210                 215                 220                 


Thr Ala Arg Val Glu Leu Cys Ala Gln Gly Ser Ala Asp Leu Ala His 
225                 230                 235                 240 


Leu Asp Asp Gly Pro Tyr Glu Ala Gly Gly Glu Lys Glu Gln Asp Pro 
                245                 250                 255     


Arg Leu Ile Pro Val Pro Ala Asn Ser Tyr Phe Gly Phe Ser Ile Asp 
            260                 265                 270         


Ser Gly Lys Gly Leu Val Arg Ala Glu Glu Leu Ser Phe Val Ala Gly 
        275                 280                 285             


Ala Pro Arg Ala Asn His Lys Gly Ala Val Val Ile Leu Arg Lys Asp 
    290                 295                 300                 


Ser Ala Ser Arg Leu Val Pro Glu Val Met Leu Ser Gly Glu Arg Leu 
305                 310                 315                 320 


Thr Ser Gly Phe Gly Tyr Ser Leu Ala Val Ala Asp Leu Asn Ser Asp 
                325                 330                 335     


Gly Trp Pro Asp Leu Ile Val Gly Ala Pro Tyr Phe Phe Glu Arg Gln 
            340                 345                 350         


Glu Glu Leu Gly Gly Ala Val Tyr Val Tyr Leu Asn Gln Gly Gly His 
        355                 360                 365             


Trp Ala Gly Ile Ser Pro Leu Arg Leu Cys Gly Ser Pro Asp Ser Met 
    370                 375                 380                 


Phe Gly Ile Ser Leu Ala Val Leu Gly Asp Leu Asn Gln Asp Gly Phe 
385                 390                 395                 400 


Pro Asp Ile Ala Val Gly Ala Pro Phe Asp Gly Asp Gly Lys Val Phe 
                405                 410                 415     


Ile Tyr His Gly Ser Ser Leu Gly Val Val Ala Lys Pro Ser Gln Val 
            420                 425                 430         


Leu Glu Gly Glu Ala Val Gly Ile Lys Ser Phe Gly Tyr Ser Leu Ser 
        435                 440                 445             


Gly Ser Leu Asp Met Asp Gly Asn Gln Tyr Pro Asp Leu Leu Val Gly 
    450                 455                 460                 


Ser Leu Ala Asp Thr Ala Val Leu Phe Arg Ala Arg Pro Ile Leu His 
465                 470                 475                 480 


Val Ser His Glu Val Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu Gln 
                485                 490                 495     


Pro Asn Cys Ala Gly Gly His Ser Val Cys Val Asp Leu Arg Val Cys 
            500                 505                 510         


Phe Ser Tyr Ile Ala Val Pro Ser Ser Tyr Ser Pro Thr Val Ala Leu 
        515                 520                 525             


Asp Tyr Val Leu Asp Ala Asp Thr Asp Arg Arg Leu Arg Gly Gln Val 
    530                 535                 540                 


Pro Arg Val Thr Phe Leu Ser Arg Asn Leu Glu Glu Pro Lys His Gln 
545                 550                 555                 560 


Ala Ser Gly Thr Val Trp Leu Lys His Gln His Asp Arg Val Cys Gly 
                565                 570                 575     


Asp Ala Met Phe Gln Leu Gln Glu Asn Val Lys Asp Lys Leu Arg Ala 
            580                 585                 590         


Ile Val Val Thr Leu Ser Tyr Ser Leu Gln Thr Pro Arg Leu Arg Arg 
        595                 600                 605             


Gln Ala Pro Gly Gln Gly Leu Pro Pro Val Ala Pro Ile Leu Asn Ala 
    610                 615                 620                 


His Gln Pro Ser Thr Gln Arg Ala Glu Ile His Phe Leu Lys Gln Gly 
625                 630                 635                 640 


Cys Gly Glu Asp Lys Ile Cys Gln Ser Asn Leu Gln Leu Val Arg Ala 
                645                 650                 655     


Arg Phe Cys Thr Arg Val Ser Asp Thr Glu Phe Gln Pro Leu Pro Met 
            660                 665                 670         


Asp Val Asp Gly Thr Thr Ala Leu Phe Ala Leu Ser Gly Gln Pro Val 
        675                 680                 685             


Ile Gly Leu Glu Leu Met Val Thr Asn Leu Pro Ser Asp Pro Ala Gln 
    690                 695                 700                 


Pro Gln Ala Asp Gly Asp Asp Ala His Glu Ala Gln Leu Leu Val Met 
705                 710                 715                 720 


Leu Pro Asp Ser Leu His Tyr Ser Gly Val Arg Ala Leu Asp Pro Ala 
                725                 730                 735     


Glu Lys Pro Leu Cys Leu Ser Asn Glu Asn Ala Ser His Val Glu Cys 
            740                 745                 750         


Glu Leu Gly Asn Pro Met Lys Arg Gly Ala Gln Val Thr Phe Tyr Leu 
        755                 760                 765             


Ile Leu Ser Thr Ser Gly Ile Ser Ile Glu Thr Thr Glu Leu Glu Val 
    770                 775                 780                 


Glu Leu Leu Leu Ala Thr Ile Ser Glu Gln Glu Leu His Pro Val Ser 
785                 790                 795                 800 


Ala Arg Ala Arg Val Phe Ile Glu Leu Pro Leu Ser Ile Ala Gly Met 
                805                 810                 815     


Ala Ile Pro Gln Gln Leu Phe Phe Ser Gly Val Val Arg Gly Glu Arg 
            820                 825                 830         


Ala Met Gln Ser Glu Arg Asp Val Gly Ser Lys Val Lys Tyr Glu Val 
        835                 840                 845             


Thr Val Ser Asn Gln Gly Gln Ser Leu Arg Thr Leu Gly Ser Ala Phe 
    850                 855                 860                 


Leu Asn Ile Met Trp Pro His Glu Ile Ala Asn Gly Lys Trp Leu Leu 
865                 870                 875                 880 


Tyr Pro Met Gln Val Glu Leu Glu Gly Gly Gln Gly Pro Gly Gln Lys 
                885                 890                 895     


Gly Leu Cys Ser Pro Arg Pro Asn Ile Leu His Leu Asp Val Asp Ser 
            900                 905                 910         


Arg Asp Arg Arg Arg Arg Glu Leu Glu Pro Pro Glu Gln Gln Glu Pro 
        915                 920                 925             


Gly Glu Arg Gln Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala 
    930                 935                 940                 


Glu Lys Lys Lys Asn Ile Thr Leu Asp Cys Ala Arg Gly Thr Ala Asn 
945                 950                 955                 960 


Cys Val Val Phe Ser Cys Pro Leu Tyr Ser Phe Asp Arg Ala Ala Val 
                965                 970                 975     


Leu His Val Trp Gly Arg Leu Trp Asn Ser Thr Phe Leu Glu Glu Tyr 
            980                 985                 990         


Ser Ala Val Lys Ser Leu Glu Val  Ile Val Arg Ala Asn  Ile Thr Val 
        995                 1000                 1005             


Lys Ser  Ser Ile Lys Asn Leu  Met Leu Arg Asp Ala  Ser Thr Val 
    1010                 1015                 1020             


Ile Pro  Val Met Val Tyr Leu  Asp Pro Met Ala Val  Val Ala Glu 
    1025                 1030                 1035             


Gly Val  Pro Trp Trp Val Ile  Leu Leu Ala Val Leu  Ala Gly Leu 
    1040                 1045                 1050             


Leu Val  Leu Ala Leu Leu Val  Leu Leu Leu Trp Lys  Met Gly Phe 
    1055                 1060                 1065             


Phe Lys  Arg Ala Lys His Pro  Glu Ala Thr Val Pro  Gln Tyr His 
    1070                 1075                 1080             


Ala Val  Lys Ile Pro Arg Glu  Asp Arg Gln Gln Phe  Lys Glu Glu 
    1085                 1090                 1095             


Lys Thr  Gly Thr Ile Leu Arg  Asn Asn Trp Gly Ser  Pro Arg Arg 
    1100                 1105                 1110             


Glu Gly  Pro Asp Ala His Pro  Ile Leu Ala Ala Asp  Gly His Pro 
    1115                 1120                 1125             


Glu Leu  Gly Pro Asp Gly His  Pro Gly Pro Gly Thr  Ala 
    1130                 1135                 1140     


<210>  5615
<211>  1048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA8__Homo_sapiens__NP_001278423

<400>  5615

Met Ser Pro Gly Ala Ser Arg Gly Pro Arg Gly Ser Gln Ala Pro Leu 
1               5                   10                  15      


Ile Ala Pro Leu Cys Cys Ala Ala Ala Ala Leu Gly Met Leu Leu Trp 
            20                  25                  30          


Ser Pro Ala Cys Gln Ala Phe Asn Leu Asp Val Glu Lys Leu Thr Val 
        35                  40                  45              


Tyr Ser Gly Pro Lys Gly Ser Tyr Phe Gly Tyr Ala Val Asp Phe His 
    50                  55                  60                  


Ile Pro Asp Ala Arg Thr Ala Ser Val Leu Val Gly Ala Pro Lys Ala 
65                  70                  75                  80  


Asn Thr Ser Gln Pro Asp Ile Val Glu Gly Gly Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Trp Pro Ala Glu Gly Ser Ala Gln Cys Arg Gln Ile Pro Phe Asp 
            100                 105                 110         


Thr Thr Asn Asn Arg Lys Ile Arg Val Asn Gly Thr Lys Glu Pro Ile 
        115                 120                 125             


Glu Phe Lys Ser Asn Gln Trp Phe Gly Ala Thr Val Lys Ala His Lys 
    130                 135                 140                 


Gly Lys Val Val Ala Cys Ala Pro Leu Tyr His Trp Arg Thr Leu Lys 
145                 150                 155                 160 


Pro Thr Pro Glu Lys Asp Pro Val Gly Thr Cys Tyr Val Ala Ile Gln 
                165                 170                 175     


Asn Phe Ser Ala Tyr Ala Glu Phe Ser Pro Cys Arg Asn Ser Asn Ala 
            180                 185                 190         


Asp Pro Glu Gly Gln Gly Tyr Cys Gln Ala Gly Phe Ser Leu Asp Phe 
        195                 200                 205             


Tyr Lys Asn Gly Asp Leu Ile Val Gly Gly Pro Gly Ser Phe Tyr Trp 
    210                 215                 220                 


Gln Gly Gln Val Ile Thr Ala Ser Val Ala Asp Ile Ile Ala Asn Tyr 
225                 230                 235                 240 


Ser Phe Lys Asp Ile Leu Arg Lys Leu Ala Gly Glu Lys Gln Thr Glu 
                245                 250                 255     


Val Ala Pro Ala Ser Tyr Asp Asp Ser Tyr Leu Glu Leu Val Ala Gly 
            260                 265                 270         


Ile Pro Arg Gly Ala Gln Asn Phe Gly Tyr Val Ser Ile Ile Asn Ser 
        275                 280                 285             


Thr Asp Met Thr Phe Ile Gln Asn Phe Thr Gly Glu Gln Met Ala Ser 
    290                 295                 300                 


Tyr Phe Gly Tyr Thr Val Val Val Ser Asp Val Asn Ser Asp Gly Leu 
305                 310                 315                 320 


Asp Asp Val Leu Val Gly Ala Pro Leu Phe Met Glu Arg Glu Phe Glu 
                325                 330                 335     


Ser Asn Pro Arg Glu Val Gly Gln Ile Tyr Leu Tyr Leu Gln Val Ser 
            340                 345                 350         


Ser Leu Leu Phe Arg Asp Pro Gln Ile Leu Thr Gly Thr Glu Thr Phe 
        355                 360                 365             


Gly Arg Phe Gly Ser Ala Met Ala His Leu Gly Asp Leu Asn Gln Asp 
    370                 375                 380                 


Gly Tyr Asn Asp Ile Ala Ile Gly Val Pro Phe Ala Gly Lys Asp Gln 
385                 390                 395                 400 


Arg Gly Lys Val Leu Ile Tyr Asn Gly Asn Lys Asp Gly Leu Asn Thr 
                405                 410                 415     


Lys Pro Ser Gln Val Leu Gln Gly Val Trp Ala Ser His Ala Val Pro 
            420                 425                 430         


Ser Gly Phe Gly Phe Thr Leu Arg Gly Asp Ser Asp Ile Asp Lys Asn 
        435                 440                 445             


Asp Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Thr Gly Lys Val Ala 
    450                 455                 460                 


Val Tyr Arg Ala Arg Pro Val Val Thr Val Asp Ala Gln Leu Leu Leu 
465                 470                 475                 480 


His Pro Met Ile Ile Asn Leu Glu Asn Lys Thr Cys Gln Val Pro Asp 
                485                 490                 495     


Ser Met Thr Ser Ala Ala Cys Phe Ser Leu Arg Val Cys Ala Ser Val 
            500                 505                 510         


Thr Gly Gln Ser Ile Ala Asn Thr Ile Val Leu Met Ala Glu Val Gln 
        515                 520                 525             


Leu Asp Ser Leu Lys Gln Lys Gly Ala Ile Lys Arg Thr Leu Phe Leu 
    530                 535                 540                 


Asp Asn His Gln Ala His Arg Val Phe Pro Leu Val Ile Lys Arg Gln 
545                 550                 555                 560 


Lys Ser His Gln Cys Gln Asp Phe Ile Val Tyr Leu Arg Asp Glu Thr 
                565                 570                 575     


Glu Phe Arg Asp Lys Leu Ser Pro Ile Asn Ile Ser Leu Asn Tyr Ser 
            580                 585                 590         


Leu Asp Glu Ser Thr Phe Lys Glu Gly Leu Glu Val Lys Pro Ile Leu 
        595                 600                 605             


Asn Tyr Tyr Arg Glu Asn Ile Val Ser Glu Gln Ala His Ile Leu Val 
    610                 615                 620                 


Asp Cys Gly Glu Asp Asn Leu Cys Val Pro Asp Leu Lys Leu Ser Ala 
625                 630                 635                 640 


Arg Pro Asp Lys His Gln Val Ile Ile Gly Asp Glu Asn His Leu Met 
                645                 650                 655     


Leu Ile Ile Asn Ala Arg Asn Glu Gly Glu Gly Ala Tyr Glu Ala Glu 
            660                 665                 670         


Leu Phe Val Met Ile Pro Glu Glu Ala Asp Tyr Val Gly Ile Glu Arg 
        675                 680                 685             


Asn Asn Lys Gly Phe Arg Pro Leu Ser Cys Glu Tyr Lys Met Glu Asn 
    690                 695                 700                 


Val Thr Arg Met Val Val Cys Asp Leu Gly Asn Pro Met Val Ser Gly 
705                 710                 715                 720 


Thr Asn Tyr Ser Leu Gly Leu Arg Phe Ala Val Pro Arg Leu Glu Lys 
                725                 730                 735     


Thr Asn Met Ser Ile Asn Phe Asp Leu Gln Ile Arg Ser Ser Asn Lys 
            740                 745                 750         


Asp Asn Pro Asp Ser Asn Phe Val Ser Leu Gln Ile Asn Ile Thr Ala 
        755                 760                 765             


Val Ala Gln Val Glu Ile Arg Gly Val Ser His Pro Pro Gln Ile Val 
    770                 775                 780                 


Leu Pro Ile His Asn Trp Glu Pro Glu Glu Glu Pro His Lys Glu Glu 
785                 790                 795                 800 


Glu Val Gly Pro Leu Val Glu His Ile Tyr Glu Leu His Asn Ile Gly 
                805                 810                 815     


Pro Ser Thr Ile Ser Asp Thr Ile Leu Glu Val Gly Trp Pro Phe Ser 
            820                 825                 830         


Ala Arg Asp Glu Phe Leu Leu Tyr Ile Phe His Ile Gln Thr Leu Gly 
        835                 840                 845             


Pro Leu Gln Cys Gln Pro Asn Pro Asn Ile Asn Pro Gln Asp Ile Lys 
    850                 855                 860                 


Pro Ala Ala Ser Pro Glu Asp Thr Pro Glu Leu Ser Ala Phe Leu Arg 
865                 870                 875                 880 


Asn Ser Thr Ile Pro His Leu Val Arg Lys Arg Asp Val His Val Val 
                885                 890                 895     


Glu Phe His Arg Gln Ser Pro Ala Lys Ile Leu Asn Cys Thr Asn Ile 
            900                 905                 910         


Glu Cys Leu Gln Ile Ser Cys Ala Val Gly Arg Leu Glu Gly Gly Glu 
        915                 920                 925             


Ser Ala Val Leu Lys Val Arg Ser Arg Leu Trp Ala His Thr Phe Leu 
    930                 935                 940                 


Gln Arg Lys Asn Asp Pro Tyr Ala Leu Ala Ser Leu Val Ser Phe Glu 
945                 950                 955                 960 


Val Lys Lys Met Pro Tyr Thr Asp Gln Pro Ala Lys Leu Pro Glu Gly 
                965                 970                 975     


Ser Ile Val Ile Lys Thr Ser Val Ile Trp Ala Thr Pro Asn Val Ser 
            980                 985                 990         


Phe Ser Ile Pro Leu Trp Val Ile  Ile Leu Ala Ile Leu  Leu Gly Leu 
        995                 1000                 1005             


Leu Val  Leu Ala Ile Leu Thr  Leu Ala Leu Trp Lys  Cys Gly Phe 
    1010                 1015                 1020             


Phe Asp  Arg Ala Arg Pro Pro  Gln Glu Asp Met Thr  Asp Arg Glu 
    1025                 1030                 1035             


Gln Leu  Thr Asn Asp Lys Thr  Pro Glu Ala 
    1040                 1045             


<210>  5616
<211>  1035
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGA9__Homo_sapiens__NP_002198

<400>  5616

Met Gly Gly Pro Ala Ala Pro Arg Gly Ala Gly Arg Leu Arg Ala Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Val Ala Gly Ile Pro Ala Gly Ala Tyr Asn Leu 
            20                  25                  30          


Asp Pro Gln Arg Pro Val His Phe Gln Gly Pro Ala Asp Ser Phe Phe 
        35                  40                  45              


Gly Tyr Ala Val Leu Glu His Phe His Asp Asn Thr Arg Trp Val Leu 
    50                  55                  60                  


Val Gly Ala Pro Lys Ala Asp Ser Lys Tyr Ser Pro Ser Val Lys Ser 
65                  70                  75                  80  


Pro Gly Ala Val Phe Lys Cys Arg Val His Thr Asn Pro Asp Arg Arg 
                85                  90                  95      


Cys Thr Glu Leu Asp Met Ala Arg Gly Lys Asn Arg Gly Thr Ser Cys 
            100                 105                 110         


Gly Lys Thr Cys Arg Glu Asp Arg Asp Asp Glu Trp Met Gly Val Ser 
        115                 120                 125             


Leu Ala Arg Gln Pro Lys Ala Asp Gly Arg Val Leu Ala Cys Ala His 
    130                 135                 140                 


Arg Trp Lys Asn Ile Tyr Tyr Glu Ala Asp His Ile Leu Pro His Gly 
145                 150                 155                 160 


Phe Cys Tyr Ile Ile Pro Ser Asn Leu Gln Ala Lys Gly Arg Thr Leu 
                165                 170                 175     


Ile Pro Cys Tyr Glu Glu Tyr Lys Lys Lys Tyr Gly Glu Glu His Gly 
            180                 185                 190         


Ser Cys Gln Ala Gly Ile Ala Gly Phe Phe Thr Glu Glu Leu Val Val 
        195                 200                 205             


Met Gly Ala Pro Gly Ser Phe Tyr Trp Ala Gly Thr Ile Lys Val Leu 
    210                 215                 220                 


Asn Leu Thr Asp Asn Thr Tyr Leu Lys Leu Asn Asp Glu Val Ile Met 
225                 230                 235                 240 


Asn Arg Arg Tyr Thr Tyr Leu Gly Tyr Ala Val Thr Ala Gly His Phe 
                245                 250                 255     


Ser His Pro Ser Thr Ile Asp Val Val Gly Gly Ala Pro Gln Asp Lys 
            260                 265                 270         


Gly Ile Gly Lys Val Tyr Ile Phe Arg Ala Asp Arg Arg Ser Gly Thr 
        275                 280                 285             


Leu Ile Lys Ile Phe Gln Ala Ser Gly Lys Lys Met Gly Ser Tyr Phe 
    290                 295                 300                 


Gly Ser Ser Leu Cys Ala Val Asp Leu Asn Gly Asp Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Leu Val Gly Ala Pro Met Phe Ser Glu Ile Arg Asp Glu Gly Gln 
                325                 330                 335     


Val Thr Val Tyr Ile Asn Arg Gly Asn Gly Ala Leu Glu Glu Gln Leu 
            340                 345                 350         


Ala Leu Thr Gly Asp Gly Ala Tyr Asn Ala His Phe Gly Glu Ser Ile 
        355                 360                 365             


Ala Ser Leu Asp Asp Leu Asp Asn Asp Gly Phe Pro Asp Val Ala Ile 
    370                 375                 380                 


Gly Ala Pro Lys Glu Asp Asp Phe Ala Gly Ala Val Tyr Ile Tyr His 
385                 390                 395                 400 


Gly Asp Ala Gly Gly Ile Val Pro Gln Tyr Ser Met Lys Leu Ser Gly 
                405                 410                 415     


Gln Lys Ile Asn Pro Val Leu Arg Met Phe Gly Gln Ser Ile Ser Gly 
            420                 425                 430         


Gly Ile Asp Met Asp Gly Asn Gly Tyr Pro Asp Val Thr Val Gly Ala 
        435                 440                 445             


Phe Met Ser Asp Ser Val Val Leu Leu Arg Ala Arg Pro Val Ile Thr 
    450                 455                 460                 


Val Asp Val Ser Ile Phe Leu Pro Gly Ser Ile Asn Ile Thr Ala Pro 
465                 470                 475                 480 


Gln Cys His Asp Gly Gln Gln Pro Val Asn Cys Leu Asn Val Thr Thr 
                485                 490                 495     


Cys Phe Ser Phe His Gly Lys His Val Pro Gly Glu Ile Gly Leu Asn 
            500                 505                 510         


Tyr Val Leu Met Ala Asp Val Ala Lys Lys Glu Lys Gly Gln Met Pro 
        515                 520                 525             


Arg Val Tyr Phe Val Leu Leu Gly Glu Thr Met Gly Gln Val Thr Glu 
    530                 535                 540                 


Lys Leu Gln Leu Thr Tyr Met Glu Glu Thr Cys Arg His Tyr Val Ala 
545                 550                 555                 560 


His Val Lys Arg Arg Val Gln Asp Val Ile Ser Pro Ile Val Phe Glu 
                565                 570                 575     


Ala Ala Tyr Ser Leu Ser Glu His Val Thr Gly Glu Glu Glu Arg Glu 
            580                 585                 590         


Leu Pro Pro Leu Thr Pro Val Leu Arg Trp Lys Lys Gly Gln Lys Ile 
        595                 600                 605             


Ala Gln Lys Asn Gln Thr Val Phe Glu Arg Asn Cys Arg Ser Glu Asp 
    610                 615                 620                 


Cys Ala Ala Asp Leu Gln Leu Gln Gly Lys Leu Leu Leu Ser Ser Met 
625                 630                 635                 640 


Asp Glu Lys Thr Leu Tyr Leu Ala Leu Gly Ala Val Lys Asn Ile Ser 
                645                 650                 655     


Leu Asn Ile Ser Ile Ser Asn Leu Gly Asp Asp Ala Tyr Asp Ala Asn 
            660                 665                 670         


Val Ser Phe Asn Val Ser Arg Glu Leu Phe Phe Ile Asn Met Trp Gln 
        675                 680                 685             


Lys Glu Glu Met Gly Ile Ser Cys Glu Leu Leu Glu Ser Asp Phe Leu 
    690                 695                 700                 


Lys Cys Ser Val Gly Phe Pro Phe Met Arg Ser Lys Ser Lys Tyr Glu 
705                 710                 715                 720 


Phe Ser Val Ile Phe Asp Thr Ser His Leu Ser Gly Glu Glu Glu Val 
                725                 730                 735     


Leu Ser Phe Ile Val Thr Ala Gln Ser Gly Asn Thr Glu Arg Ser Glu 
            740                 745                 750         


Ser Leu His Asp Asn Thr Leu Val Leu Met Val Pro Leu Met His Glu 
        755                 760                 765             


Val Asp Thr Ser Ile Thr Gly Ile Met Ser Pro Thr Ser Phe Val Tyr 
    770                 775                 780                 


Gly Glu Ser Val Asp Ala Ala Asn Phe Ile Gln Leu Asp Asp Leu Glu 
785                 790                 795                 800 


Cys His Phe Gln Pro Ile Asn Ile Thr Leu Gln Val Tyr Asn Thr Gly 
                805                 810                 815     


Pro Ser Thr Leu Pro Gly Ser Ser Val Ser Ile Ser Phe Pro Asn Arg 
            820                 825                 830         


Leu Ser Ser Gly Gly Ala Glu Met Phe His Val Gln Glu Met Val Val 
        835                 840                 845             


Gly Gln Glu Lys Gly Asn Cys Ser Phe Gln Lys Asn Pro Thr Pro Cys 
    850                 855                 860                 


Ile Ile Pro Gln Glu Gln Glu Asn Ile Phe His Thr Ile Phe Ala Phe 
865                 870                 875                 880 


Phe Thr Lys Ser Gly Arg Lys Val Leu Asp Cys Glu Lys Pro Gly Ile 
                885                 890                 895     


Ser Cys Leu Thr Ala His Cys Asn Phe Ser Ala Leu Ala Lys Glu Glu 
            900                 905                 910         


Ser Arg Thr Ile Asp Ile Tyr Met Leu Leu Asn Thr Glu Ile Leu Lys 
        915                 920                 925             


Lys Asp Ser Ser Ser Val Ile Gln Phe Met Ser Arg Ala Lys Val Lys 
    930                 935                 940                 


Val Asp Pro Ala Leu Arg Val Val Glu Ile Ala His Gly Asn Pro Glu 
945                 950                 955                 960 


Glu Val Thr Val Val Phe Glu Ala Leu His Asn Leu Glu Pro Arg Gly 
                965                 970                 975     


Tyr Val Val Gly Trp Ile Ile Ala Ile Ser Leu Leu Val Gly Ile Leu 
            980                 985                 990         


Ile Phe Leu Leu Leu Ala Val Leu  Leu Trp Lys Met Gly  Phe Phe Arg 
        995                 1000                 1005             


Arg Arg  Tyr Lys Glu Ile Ile  Glu Ala Glu Lys Asn  Arg Lys Glu 
    1010                 1015                 1020             


Asn Glu  Asp Ser Trp Asp Trp  Val Gln Lys Asn Gln  
    1025                 1030                 1035 


<210>  5617
<211>  1161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGAD__Homo_sapiens__NP_005344

<400>  5617

Met Thr Phe Gly Thr Val Leu Leu Leu Ser Val Leu Ala Ser Tyr His 
1               5                   10                  15      


Gly Phe Asn Leu Asp Val Glu Glu Pro Thr Ile Phe Gln Glu Asp Ala 
            20                  25                  30          


Gly Gly Phe Gly Gln Ser Val Val Gln Phe Gly Gly Ser Arg Leu Val 
        35                  40                  45              


Val Gly Ala Pro Leu Glu Val Val Ala Ala Asn Gln Thr Gly Arg Leu 
    50                  55                  60                  


Tyr Asp Cys Ala Ala Ala Thr Gly Met Cys Gln Pro Ile Pro Leu His 
65                  70                  75                  80  


Ile Arg Pro Glu Ala Val Asn Met Ser Leu Gly Leu Thr Leu Ala Ala 
                85                  90                  95      


Ser Thr Asn Gly Ser Arg Leu Leu Ala Cys Gly Pro Thr Leu His Arg 
            100                 105                 110         


Val Cys Gly Glu Asn Ser Tyr Ser Lys Gly Ser Cys Leu Leu Leu Gly 
        115                 120                 125             


Ser Arg Trp Glu Ile Ile Gln Thr Val Pro Asp Ala Thr Pro Glu Cys 
    130                 135                 140                 


Pro His Gln Glu Met Asp Ile Val Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Asp Gln Asn Asp Phe Asn Gln Met Lys Gly Phe Val Gln Ala Val 
                165                 170                 175     


Met Gly Gln Phe Glu Gly Thr Asp Thr Leu Phe Ala Leu Met Gln Tyr 
            180                 185                 190         


Ser Asn Leu Leu Lys Ile His Phe Thr Phe Thr Gln Phe Arg Thr Ser 
        195                 200                 205             


Pro Ser Gln Gln Ser Leu Val Asp Pro Ile Val Gln Leu Lys Gly Leu 
    210                 215                 220                 


Thr Phe Thr Ala Thr Gly Ile Leu Thr Val Val Thr Gln Leu Phe His 
225                 230                 235                 240 


His Lys Asn Gly Ala Arg Lys Ser Ala Lys Lys Ile Leu Ile Val Ile 
                245                 250                 255     


Thr Asp Gly Gln Lys Tyr Lys Asp Pro Leu Glu Tyr Ser Asp Val Ile 
            260                 265                 270         


Pro Gln Ala Glu Lys Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val Gly 
        275                 280                 285             


His Ala Phe Gln Gly Pro Thr Ala Arg Gln Glu Leu Asn Thr Ile Ser 
    290                 295                 300                 


Ser Ala Pro Pro Gln Asp His Val Phe Lys Val Asp Asn Phe Ala Ala 
305                 310                 315                 320 


Leu Gly Ser Ile Gln Lys Gln Leu Gln Glu Lys Ile Tyr Ala Val Glu 
                325                 330                 335     


Gly Thr Gln Ser Arg Ala Ser Ser Ser Phe Gln His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Thr Ala Leu Thr Met Asp Gly Leu Phe Leu Gly Ala 
        355                 360                 365             


Val Gly Ser Phe Ser Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro Asn 
    370                 375                 380                 


Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met Arg 
385                 390                 395                 400 


Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly Val 
                405                 410                 415     


Gln Asn Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys Ala 
            420                 425                 430         


Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Lys Lys Ala Glu Val 
        435                 440                 445             


Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Ile Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Arg Val Gln Trp Gln Cys Asp Ala Val Leu Arg Gly Glu 
            500                 505                 510         


Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
        515                 520                 525             


Asp Val Asn Glu Asp Lys Leu Ile Asp Val Ala Ile Gly Ala Pro Gly 
    530                 535                 540                 


Glu Gln Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Ala Ser Glu 
545                 550                 555                 560 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Ser Ser Gln Leu 
                565                 570                 575     


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln Asp 
            580                 585                 590         


Leu Thr Gln Asp Gly Leu Met Asp Leu Ala Val Gly Ala Arg Gly Gln 
        595                 600                 605             


Val Leu Leu Leu Arg Ser Leu Pro Val Leu Lys Val Gly Val Ala Met 
    610                 615                 620                 


Arg Phe Ser Pro Val Glu Val Ala Lys Ala Val Tyr Arg Cys Trp Glu 
625                 630                 635                 640 


Glu Lys Pro Ser Ala Leu Glu Ala Gly Asp Ala Thr Val Cys Leu Thr 
                645                 650                 655     


Ile Gln Lys Ser Ser Leu Asp Gln Leu Gly Asp Ile Gln Ser Ser Val 
            660                 665                 670         


Arg Phe Asp Leu Ala Leu Asp Pro Gly Arg Leu Thr Ser Arg Ala Ile 
        675                 680                 685             


Phe Asn Glu Thr Lys Asn Pro Thr Leu Thr Arg Arg Lys Thr Leu Gly 
    690                 695                 700                 


Leu Gly Ile His Cys Glu Thr Leu Lys Leu Leu Leu Pro Asp Cys Val 
705                 710                 715                 720 


Glu Asp Val Val Ser Pro Ile Ile Leu His Leu Asn Phe Ser Leu Val 
                725                 730                 735     


Arg Glu Pro Ile Pro Ser Pro Gln Asn Leu Arg Pro Val Leu Ala Val 
            740                 745                 750         


Gly Ser Gln Asp Leu Phe Thr Ala Ser Leu Pro Phe Glu Lys Asn Cys 
        755                 760                 765             


Gly Gln Asp Gly Leu Cys Glu Gly Asp Leu Gly Val Thr Leu Ser Phe 
    770                 775                 780                 


Ser Gly Leu Gln Thr Leu Thr Val Gly Ser Ser Leu Glu Leu Asn Val 
785                 790                 795                 800 


Ile Val Thr Val Trp Asn Ala Gly Glu Asp Ser Tyr Gly Thr Val Val 
                805                 810                 815     


Ser Leu Tyr Tyr Pro Ala Gly Leu Ser His Arg Arg Val Ser Gly Ala 
            820                 825                 830         


Gln Lys Gln Pro His Gln Ser Ala Leu Arg Leu Ala Cys Glu Thr Val 
        835                 840                 845             


Pro Thr Glu Asp Glu Gly Leu Arg Ser Ser Arg Cys Ser Val Asn His 
    850                 855                 860                 


Pro Ile Phe His Glu Gly Ser Asn Gly Thr Phe Ile Val Thr Phe Asp 
865                 870                 875                 880 


Val Ser Tyr Lys Ala Thr Leu Gly Asp Arg Met Leu Met Arg Ala Ser 
                885                 890                 895     


Ala Ser Ser Glu Asn Asn Lys Ala Ser Ser Ser Lys Ala Thr Phe Gln 
            900                 905                 910         


Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Met Ile Ser Arg Gln 
        915                 920                 925             


Glu Glu Ser Thr Lys Tyr Phe Asn Phe Ala Thr Ser Asp Glu Lys Lys 
    930                 935                 940                 


Met Lys Glu Ala Glu His Arg Tyr Arg Val Asn Asn Leu Ser Gln Arg 
945                 950                 955                 960 


Asp Leu Ala Ile Ser Ile Asn Phe Trp Val Pro Val Leu Leu Asn Gly 
                965                 970                 975     


Val Ala Val Trp Asp Val Val Met Glu Ala Pro Ser Gln Ser Leu Pro 
            980                 985                 990         


Cys Val Ser Glu Arg Lys Pro Pro  Gln His Ser Asp Phe  Leu Thr Gln 
        995                 1000                 1005             


Ile Ser  Arg Ser Pro Met Leu  Asp Cys Ser Ile Ala  Asp Cys Leu 
    1010                 1015                 1020             


Gln Phe  Arg Cys Asp Val Pro  Ser Phe Ser Val Gln  Glu Glu Leu 
    1025                 1030                 1035             


Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe Gly Trp  Val Arg Glu 
    1040                 1045                 1050             


Thr Leu  Gln Lys Lys Val Leu  Val Val Ser Val Ala  Glu Ile Thr 
    1055                 1060                 1065             


Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro Gly Gln  Glu Ala Phe 
    1070                 1075                 1080             


Met Arg  Ala Gln Met Glu Met  Val Leu Glu Glu Asp  Glu Val Tyr 
    1085                 1090                 1095             


Asn Ala  Ile Pro Ile Ile Met  Gly Ser Ser Val Gly  Ala Leu Leu 
    1100                 1105                 1110             


Leu Leu  Ala Leu Ile Thr Ala  Thr Leu Tyr Lys Leu  Gly Phe Phe 
    1115                 1120                 1125             


Lys Arg  His Tyr Lys Glu Met  Leu Glu Asp Lys Pro  Glu Asp Thr 
    1130                 1135                 1140             


Ala Thr  Phe Ser Gly Asp Asp  Phe Ser Cys Val Ala  Pro Asn Val 
    1145                 1150                 1155             


Pro Leu  Ser 
    1160     


<210>  5618
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGAE__Homo_sapiens__NP_002199

<400>  5618

Met Trp Leu Phe His Thr Leu Leu Cys Ile Ala Ser Leu Ala Leu Leu 
1               5                   10                  15      


Ala Ala Phe Asn Val Asp Val Ala Arg Pro Trp Leu Thr Pro Lys Gly 
            20                  25                  30          


Gly Ala Pro Phe Val Leu Ser Ser Leu Leu His Gln Asp Pro Ser Thr 
        35                  40                  45              


Asn Gln Thr Trp Leu Leu Val Thr Ser Pro Arg Thr Lys Arg Thr Pro 
    50                  55                  60                  


Gly Pro Leu His Arg Cys Ser Leu Val Gln Asp Glu Ile Leu Cys His 
65                  70                  75                  80  


Pro Val Glu His Val Pro Ile Pro Lys Gly Arg His Arg Gly Val Thr 
                85                  90                  95      


Val Val Arg Ser His His Gly Val Leu Ile Cys Ile Gln Val Leu Val 
            100                 105                 110         


Arg Arg Pro His Ser Leu Ser Ser Glu Leu Thr Gly Thr Cys Ser Leu 
        115                 120                 125             


Leu Gly Pro Asp Leu Arg Pro Gln Ala Gln Ala Asn Phe Phe Asp Leu 
    130                 135                 140                 


Glu Asn Leu Leu Asp Pro Asp Ala Arg Val Asp Thr Gly Asp Cys Tyr 
145                 150                 155                 160 


Ser Asn Lys Glu Gly Gly Gly Glu Asp Asp Val Asn Thr Ala Arg Gln 
                165                 170                 175     


Arg Arg Ala Leu Glu Lys Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu 
            180                 185                 190         


Asp Glu Glu Glu Glu Glu Ala Gly Thr Glu Ile Ala Ile Ile Leu Asp 
        195                 200                 205             


Gly Ser Gly Ser Ile Asp Pro Pro Asp Phe Gln Arg Ala Lys Asp Phe 
    210                 215                 220                 


Ile Ser Asn Met Met Arg Asn Phe Tyr Glu Lys Cys Phe Glu Cys Asn 
225                 230                 235                 240 


Phe Ala Leu Val Gln Tyr Gly Gly Val Ile Gln Thr Glu Phe Asp Leu 
                245                 250                 255     


Arg Asp Ser Gln Asp Val Met Ala Ser Leu Ala Arg Val Gln Asn Ile 
            260                 265                 270         


Thr Gln Val Gly Ser Val Thr Lys Thr Ala Ser Ala Met Gln His Val 
        275                 280                 285             


Leu Asp Ser Ile Phe Thr Ser Ser His Gly Ser Arg Arg Lys Ala Ser 
    290                 295                 300                 


Lys Val Met Val Val Leu Thr Asp Gly Gly Ile Phe Glu Asp Pro Leu 
305                 310                 315                 320 


Asn Leu Thr Thr Val Ile Asn Ser Pro Lys Met Gln Gly Val Glu Arg 
                325                 330                 335     


Phe Ala Ile Gly Val Gly Glu Glu Phe Lys Ser Ala Arg Thr Ala Arg 
            340                 345                 350         


Glu Leu Asn Leu Ile Ala Ser Asp Pro Asp Glu Thr His Ala Phe Lys 
        355                 360                 365             


Val Thr Asn Tyr Met Ala Leu Asp Gly Leu Leu Ser Lys Leu Arg Tyr 
    370                 375                 380                 


Asn Ile Ile Ser Met Glu Gly Thr Val Gly Asp Ala Leu His Tyr Gln 
385                 390                 395                 400 


Leu Ala Gln Ile Gly Phe Ser Ala Gln Ile Leu Asp Glu Arg Gln Val 
                405                 410                 415     


Leu Leu Gly Ala Val Gly Ala Phe Asp Trp Ser Gly Gly Ala Leu Leu 
            420                 425                 430         


Tyr Asp Thr Arg Ser Arg Arg Gly Arg Phe Leu Asn Gln Thr Ala Ala 
        435                 440                 445             


Ala Ala Ala Asp Ala Glu Ala Ala Gln Tyr Ser Tyr Leu Gly Tyr Ala 
    450                 455                 460                 


Val Ala Val Leu His Lys Thr Cys Ser Leu Ser Tyr Ile Ala Gly Ala 
465                 470                 475                 480 


Pro Arg Tyr Lys His His Gly Ala Val Phe Glu Leu Gln Lys Glu Gly 
                485                 490                 495     


Arg Glu Ala Ser Phe Leu Pro Val Leu Glu Gly Glu Gln Met Gly Ser 
            500                 505                 510         


Tyr Phe Gly Ser Glu Leu Cys Pro Val Asp Ile Asp Met Asp Gly Ser 
        515                 520                 525             


Thr Asp Phe Leu Leu Val Ala Ala Pro Phe Tyr His Val His Gly Glu 
    530                 535                 540                 


Glu Gly Arg Val Tyr Val Tyr Arg Leu Ser Glu Gln Asp Gly Ser Phe 
545                 550                 555                 560 


Ser Leu Ala Arg Ile Leu Ser Gly His Pro Gly Phe Thr Asn Ala Arg 
                565                 570                 575     


Phe Gly Phe Ala Met Ala Ala Met Gly Asp Leu Ser Gln Asp Lys Leu 
            580                 585                 590         


Thr Asp Val Ala Ile Gly Ala Pro Leu Glu Gly Phe Gly Ala Asp Asp 
        595                 600                 605             


Gly Ala Ser Phe Gly Ser Val Tyr Ile Tyr Asn Gly His Trp Asp Gly 
    610                 615                 620                 


Leu Ser Ala Ser Pro Ser Gln Arg Ile Arg Ala Ser Thr Val Ala Pro 
625                 630                 635                 640 


Gly Leu Gln Tyr Phe Gly Met Ser Met Ala Gly Gly Phe Asp Ile Ser 
                645                 650                 655     


Gly Asp Gly Leu Ala Asp Ile Thr Val Gly Thr Leu Gly Gln Ala Val 
            660                 665                 670         


Val Phe Arg Ser Arg Pro Val Val Arg Leu Lys Val Ser Met Ala Phe 
        675                 680                 685             


Thr Pro Ser Ala Leu Pro Ile Gly Phe Asn Gly Val Val Asn Val Arg 
    690                 695                 700                 


Leu Cys Phe Glu Ile Ser Ser Val Thr Thr Ala Ser Glu Ser Gly Leu 
705                 710                 715                 720 


Arg Glu Ala Leu Leu Asn Phe Thr Leu Asp Val Asp Val Gly Lys Gln 
                725                 730                 735     


Arg Arg Arg Leu Gln Cys Ser Asp Val Arg Ser Cys Leu Gly Cys Leu 
            740                 745                 750         


Arg Glu Trp Ser Ser Gly Ser Gln Leu Cys Glu Asp Leu Leu Leu Met 
        755                 760                 765             


Pro Thr Glu Gly Glu Leu Cys Glu Glu Asp Cys Phe Ser Asn Ala Ser 
    770                 775                 780                 


Val Lys Val Ser Tyr Gln Leu Gln Thr Pro Glu Gly Gln Thr Asp His 
785                 790                 795                 800 


Pro Gln Pro Ile Leu Asp Arg Tyr Thr Glu Pro Phe Ala Ile Phe Gln 
                805                 810                 815     


Leu Pro Tyr Glu Lys Ala Cys Lys Asn Lys Leu Phe Cys Val Ala Glu 
            820                 825                 830         


Leu Gln Leu Ala Thr Thr Val Ser Gln Gln Glu Leu Val Val Gly Leu 
        835                 840                 845             


Thr Lys Glu Leu Thr Leu Asn Ile Asn Leu Thr Asn Ser Gly Glu Asp 
    850                 855                 860                 


Ser Tyr Met Thr Ser Met Ala Leu Asn Tyr Pro Arg Asn Leu Gln Leu 
865                 870                 875                 880 


Lys Arg Met Gln Lys Pro Pro Ser Pro Asn Ile Gln Cys Asp Asp Pro 
                885                 890                 895     


Gln Pro Val Ala Ser Val Leu Ile Met Asn Cys Arg Ile Gly His Pro 
            900                 905                 910         


Val Leu Lys Arg Ser Ser Ala His Val Ser Val Val Trp Gln Leu Glu 
        915                 920                 925             


Glu Asn Ala Phe Pro Asn Arg Thr Ala Asp Ile Thr Val Thr Val Thr 
    930                 935                 940                 


Asn Ser Asn Glu Arg Arg Ser Leu Ala Asn Glu Thr His Thr Leu Gln 
945                 950                 955                 960 


Phe Arg His Gly Phe Val Ala Val Leu Ser Lys Pro Ser Ile Met Tyr 
                965                 970                 975     


Val Asn Thr Gly Gln Gly Leu Ser His His Lys Glu Phe Leu Phe His 
            980                 985                 990         


Val His Gly Glu Asn Leu Phe Gly  Ala Glu Tyr Gln Leu  Gln Ile Cys 
        995                 1000                 1005             


Val Pro  Thr Lys Leu Arg Gly  Leu Gln Val Val Ala  Val Lys Lys 
    1010                 1015                 1020             


Leu Thr  Arg Thr Gln Ala Ser  Thr Val Cys Thr Trp  Ser Gln Glu 
    1025                 1030                 1035             


Arg Ala  Cys Ala Tyr Ser Ser  Val Gln His Val Glu  Glu Trp His 
    1040                 1045                 1050             


Ser Val  Ser Cys Val Ile Ala  Ser Asp Lys Glu Asn  Val Thr Val 
    1055                 1060                 1065             


Ala Ala  Glu Ile Ser Trp Asp  His Ser Glu Glu Leu  Leu Lys Asp 
    1070                 1075                 1080             


Val Thr  Glu Leu Gln Ile Leu  Gly Glu Ile Ser Phe  Asn Lys Ser 
    1085                 1090                 1095             


Leu Tyr  Glu Gly Leu Asn Ala  Glu Asn His Arg Thr  Lys Ile Thr 
    1100                 1105                 1110             


Val Val  Phe Leu Lys Asp Glu  Lys Tyr His Ser Leu  Pro Ile Ile 
    1115                 1120                 1125             


Ile Lys  Gly Ser Val Gly Gly  Leu Leu Val Leu Ile  Val Ile Leu 
    1130                 1135                 1140             


Val Ile  Leu Phe Lys Cys Gly  Phe Phe Lys Arg Lys  Tyr Gln Gln 
    1145                 1150                 1155             


Leu Asn  Leu Glu Ser Ile Arg  Lys Ala Gln Leu Lys  Ser Glu Asn 
    1160                 1165                 1170             


Leu Leu  Glu Glu Glu Asn 
    1175                 


<210>  5619
<211>  1086
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGAL__Homo_sapiens__NP_001107852

<400>  5619

Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Phe Ala Ala 
            100                 105                 110         


Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr 
        115                 120                 125             


Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met 
    130                 135                 140                 


Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu 
145                 150                 155                 160 


Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu 
                165                 170                 175     


Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala 
            180                 185                 190         


Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln 
        195                 200                 205             


Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala 
    210                 215                 220                 


Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu 
225                 230                 235                 240 


Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys 
                245                 250                 255     


Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile Ser 
            260                 265                 270         


Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val Gly Ala Lys 
        275                 280                 285             


Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp 
    290                 295                 300                 


Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr 
305                 310                 315                 320 


Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu 
                325                 330                 335     


Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg Val Leu Leu 
            340                 345                 350         


Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val Gln Thr Ile 
        355                 360                 365             


His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val 
    370                 375                 380                 


Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro 
385                 390                 395                 400 


Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg 
                405                 410                 415     


Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly Asp Pro Gly 
            420                 425                 430         


Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile 
        435                 440                 445             


Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro Leu Glu Glu 
    450                 455                 460                 


Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly Leu Ser Pro 
465                 470                 475                 480 


Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser Gly Ile Gln 
                485                 490                 495     


Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu Gly Asp Gly 
            500                 505                 510         


Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile Val Leu Ser 
        515                 520                 525             


Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala 
    530                 535                 540                 


Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys 
545                 550                 555                 560 


Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu 
                565                 570                 575     


Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu 
            580                 585                 590         


Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly 
        595                 600                 605             


Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys 
    610                 615                 620                 


Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu Ile Ser 
625                 630                 635                 640 


Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr 
                645                 650                 655     


Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro 
            660                 665                 670         


Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly 
        675                 680                 685             


Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala 
    690                 695                 700                 


Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu 
705                 710                 715                 720 


Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp 
                725                 730                 735     


Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys 
            740                 745                 750         


Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser 
        755                 760                 765             


Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe 
    770                 775                 780                 


Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn Thr Leu Val 
785                 790                 795                 800 


Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys 
                805                 810                 815     


Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile 
            820                 825                 830         


Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp 
        835                 840                 845             


Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln 
    850                 855                 860                 


Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His 
865                 870                 875                 880 


Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser 
                885                 890                 895     


Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Val 
            900                 905                 910         


Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro 
        915                 920                 925             


Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu 
    930                 935                 940                 


Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu 
945                 950                 955                 960 


Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn 
                965                 970                 975     


Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln 
            980                 985                 990         


Val Val Met Lys Val Asp Val Val  Tyr Glu Lys Gln Met  Leu Tyr Leu 
        995                 1000                 1005             


Tyr Val  Leu Ser Gly Ile Gly  Gly Leu Leu Leu Leu  Leu Leu Ile 
    1010                 1015                 1020             


Phe Ile  Val Leu Tyr Lys Val  Gly Phe Phe Lys Arg  Asn Leu Lys 
    1025                 1030                 1035             


Glu Lys  Met Glu Ala Gly Arg  Gly Val Pro Asn Gly  Ile Pro Ala 
    1040                 1045                 1050             


Glu Asp  Ser Glu Gln Leu Ala  Ser Gly Gln Glu Ala  Gly Asp Pro 
    1055                 1060                 1065             


Gly Cys  Leu Lys Pro Leu His  Glu Lys Asp Ser Glu  Ser Gly Gly 
    1070                 1075                 1080             


Gly Lys  Asp 
    1085     


<210>  5620
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGAM__Homo_sapiens__NP_000623

<400>  5620

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly Glu 
            500                 505                 510         


Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
        515                 520                 525             


Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly 
    530                 535                 540                 


Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser Gly 
545                 550                 555                 560 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys Leu 
                565                 570                 575     


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln Asp 
            580                 585                 590         


Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly His 
        595                 600                 605             


Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile Met 
    610                 615                 620                 


Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn Asp 
625                 630                 635                 640 


Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu His 
                645                 650                 655     


Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln Ser 
            660                 665                 670         


Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser Arg 
        675                 680                 685             


Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln Val 
    690                 695                 700                 


Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro Asn 
705                 710                 715                 720 


Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe Ser 
                725                 730                 735     


Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val Leu 
            740                 745                 750         


Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu Lys 
        755                 760                 765             


Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr Phe 
    770                 775                 780                 


Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu Phe 
785                 790                 795                 800 


Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg Thr 
                805                 810                 815     


Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val Ser 
            820                 825                 830         


Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys Glu 
        835                 840                 845             


Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser Cys 
    850                 855                 860                 


Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe Asn 
865                 870                 875                 880 


Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu Leu 
                885                 890                 895     


Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn Lys 
            900                 905                 910         


Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met Val 
        915                 920                 925             


Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala Ser 
    930                 935                 940                 


Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val Arg 
                965                 970                 975     


Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser Glu 
            980                 985                 990         


Asn Leu Ser Ser Thr Cys His Thr  Lys Glu Arg Leu Pro  Ser His Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala Glu Leu Arg  Lys Ala Pro Val Val  Asn Cys Ser 
    1010                 1015                 1020             


Ile Ala  Val Cys Gln Arg Ile  Gln Cys Asp Ile Pro  Phe Phe Gly 
    1025                 1030                 1035             


Ile Gln  Glu Glu Phe Asn Ala  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Asp Trp  Tyr Ile Lys Thr Ser  His Asn His Leu Leu  Ile Val Ser 
    1055                 1060                 1065             


Thr Ala  Glu Ile Leu Phe Asn  Asp Ser Val Phe Thr  Leu Leu Pro 
    1070                 1075                 1080             


Gly Gln  Gly Ala Phe Val Arg  Ser Gln Thr Glu Thr  Lys Val Glu 
    1085                 1090                 1095             


Pro Phe  Glu Val Pro Asn Pro  Leu Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Val Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Ala Leu Tyr 
    1115                 1120                 1125             


Lys Leu  Gly Phe Phe Lys Arg  Gln Tyr Lys Asp Met  Met Ser Glu 
    1130                 1135                 1140             


Gly Gly  Pro Pro Gly Ala Glu  Pro Gln 
    1145                 1150         


<210>  5621
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGAV__Homo_sapiens__NP_001138471

<400>  5621

Met Leu Leu Gly Thr Leu Leu Leu Ile Leu Tyr Ile Leu Met Leu Cys 
1               5                   10                  15      


Arg Met Phe Leu Leu Val Gly Ala Pro Lys Ala Asn Thr Thr Gln Pro 
            20                  25                  30          


Gly Ile Val Glu Gly Gly Gln Val Leu Lys Cys Asp Trp Ser Ser Thr 
        35                  40                  45              


Arg Arg Cys Gln Pro Ile Glu Phe Asp Ala Thr Gly Asn Arg Asp Tyr 
    50                  55                  60                  


Ala Lys Asp Asp Pro Leu Glu Phe Lys Ser His Gln Trp Phe Gly Ala 
65                  70                  75                  80  


Ser Val Arg Ser Lys Gln Asp Lys Ile Leu Ala Cys Ala Pro Leu Tyr 
                85                  90                  95      


His Trp Arg Thr Glu Met Lys Gln Glu Arg Glu Pro Val Gly Thr Cys 
            100                 105                 110         


Phe Leu Gln Asp Gly Thr Lys Thr Val Glu Tyr Ala Pro Cys Arg Ser 
        115                 120                 125             


Gln Asp Ile Asp Ala Asp Gly Gln Gly Phe Cys Gln Gly Gly Phe Ser 
    130                 135                 140                 


Ile Asp Phe Thr Lys Ala Asp Arg Val Leu Leu Gly Gly Pro Gly Ser 
145                 150                 155                 160 


Phe Tyr Trp Gln Gly Gln Leu Ile Ser Asp Gln Val Ala Glu Ile Val 
                165                 170                 175     


Ser Lys Tyr Asp Pro Asn Val Tyr Ser Ile Lys Tyr Asn Asn Gln Leu 
            180                 185                 190         


Ala Thr Arg Thr Ala Gln Ala Ile Phe Asp Asp Ser Tyr Leu Gly Tyr 
        195                 200                 205             


Ser Val Ala Val Gly Asp Phe Asn Gly Asp Gly Ile Asp Asp Phe Val 
    210                 215                 220                 


Ser Gly Val Pro Arg Ala Ala Arg Thr Leu Gly Met Val Tyr Ile Tyr 
225                 230                 235                 240 


Asp Gly Lys Asn Met Ser Ser Leu Tyr Asn Phe Thr Gly Glu Gln Met 
                245                 250                 255     


Ala Ala Tyr Phe Gly Phe Ser Val Ala Ala Thr Asp Ile Asn Gly Asp 
            260                 265                 270         


Asp Tyr Ala Asp Val Phe Ile Gly Ala Pro Leu Phe Met Asp Arg Gly 
        275                 280                 285             


Ser Asp Gly Lys Leu Gln Glu Val Gly Gln Val Ser Val Ser Leu Gln 
    290                 295                 300                 


Arg Ala Ser Gly Asp Phe Gln Thr Thr Lys Leu Asn Gly Phe Glu Val 
305                 310                 315                 320 


Phe Ala Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Gln 
                325                 330                 335     


Asp Gly Phe Asn Asp Ile Ala Ile Ala Ala Pro Tyr Gly Gly Glu Asp 
            340                 345                 350         


Lys Lys Gly Ile Val Tyr Ile Phe Asn Gly Arg Ser Thr Gly Leu Asn 
        355                 360                 365             


Ala Val Pro Ser Gln Ile Leu Glu Gly Gln Trp Ala Ala Arg Ser Met 
    370                 375                 380                 


Pro Pro Ser Phe Gly Tyr Ser Met Lys Gly Ala Thr Asp Ile Asp Lys 
385                 390                 395                 400 


Asn Gly Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Val Asp Arg Ala 
                405                 410                 415     


Ile Leu Tyr Arg Ala Arg Pro Val Ile Thr Val Asn Ala Gly Leu Glu 
            420                 425                 430         


Val Tyr Pro Ser Ile Leu Asn Gln Asp Asn Lys Thr Cys Ser Leu Pro 
        435                 440                 445             


Gly Thr Ala Leu Lys Val Ser Cys Phe Asn Val Arg Phe Cys Leu Lys 
    450                 455                 460                 


Ala Asp Gly Lys Gly Val Leu Pro Arg Lys Leu Asn Phe Gln Val Glu 
465                 470                 475                 480 


Leu Leu Leu Asp Lys Leu Lys Gln Lys Gly Ala Ile Arg Arg Ala Leu 
                485                 490                 495     


Phe Leu Tyr Ser Arg Ser Pro Ser His Ser Lys Asn Met Thr Ile Ser 
            500                 505                 510         


Arg Gly Gly Leu Met Gln Cys Glu Glu Leu Ile Ala Tyr Leu Arg Asp 
        515                 520                 525             


Glu Ser Glu Phe Arg Asp Lys Leu Thr Pro Ile Thr Ile Phe Met Glu 
    530                 535                 540                 


Tyr Arg Leu Asp Tyr Arg Thr Ala Ala Asp Thr Thr Gly Leu Gln Pro 
545                 550                 555                 560 


Ile Leu Asn Gln Phe Thr Pro Ala Asn Ile Ser Arg Gln Ala His Ile 
                565                 570                 575     


Leu Leu Asp Cys Gly Glu Asp Asn Val Cys Lys Pro Lys Leu Glu Val 
            580                 585                 590         


Ser Val Asp Ser Asp Gln Lys Lys Ile Tyr Ile Gly Asp Asp Asn Pro 
        595                 600                 605             


Leu Thr Leu Ile Val Lys Ala Gln Asn Gln Gly Glu Gly Ala Tyr Glu 
    610                 615                 620                 


Ala Glu Leu Ile Val Ser Ile Pro Leu Gln Ala Asp Phe Ile Gly Val 
625                 630                 635                 640 


Val Arg Asn Asn Glu Ala Leu Ala Arg Leu Ser Cys Ala Phe Lys Thr 
                645                 650                 655     


Glu Asn Gln Thr Arg Gln Val Val Cys Asp Leu Gly Asn Pro Met Lys 
            660                 665                 670         


Ala Gly Thr Gln Leu Leu Ala Gly Leu Arg Phe Ser Val His Gln Gln 
        675                 680                 685             


Ser Glu Met Asp Thr Ser Val Lys Phe Asp Leu Gln Ile Gln Ser Ser 
    690                 695                 700                 


Asn Leu Phe Asp Lys Val Ser Pro Val Val Ser His Lys Val Asp Leu 
705                 710                 715                 720 


Ala Val Leu Ala Ala Val Glu Ile Arg Gly Val Ser Ser Pro Asp His 
                725                 730                 735     


Ile Phe Leu Pro Ile Pro Asn Trp Glu His Lys Glu Asn Pro Glu Thr 
            740                 745                 750         


Glu Glu Asp Val Gly Pro Val Val Gln His Ile Tyr Glu Leu Arg Asn 
        755                 760                 765             


Asn Gly Pro Ser Ser Phe Ser Lys Ala Met Leu His Leu Gln Trp Pro 
    770                 775                 780                 


Tyr Lys Tyr Asn Asn Asn Thr Leu Leu Tyr Ile Leu His Tyr Asp Ile 
785                 790                 795                 800 


Asp Gly Pro Met Asn Cys Thr Ser Asp Met Glu Ile Asn Pro Leu Arg 
                805                 810                 815     


Ile Lys Ile Ser Ser Leu Gln Thr Thr Glu Lys Asn Asp Thr Val Ala 
            820                 825                 830         


Gly Gln Gly Glu Arg Asp His Leu Ile Thr Lys Arg Asp Leu Ala Leu 
        835                 840                 845             


Ser Glu Gly Asp Ile His Thr Leu Gly Cys Gly Val Ala Gln Cys Leu 
    850                 855                 860                 


Lys Ile Val Cys Gln Val Gly Arg Leu Asp Arg Gly Lys Ser Ala Ile 
865                 870                 875                 880 


Leu Tyr Val Lys Ser Leu Leu Trp Thr Glu Thr Phe Met Asn Lys Glu 
                885                 890                 895     


Asn Gln Asn His Ser Tyr Ser Leu Lys Ser Ser Ala Ser Phe Asn Val 
            900                 905                 910         


Ile Glu Phe Pro Tyr Lys Asn Leu Pro Ile Glu Asp Ile Thr Asn Ser 
        915                 920                 925             


Thr Leu Val Thr Thr Asn Val Thr Trp Gly Ile Gln Pro Ala Pro Met 
    930                 935                 940                 


Pro Val Pro Val Trp Val Ile Ile Leu Ala Val Leu Ala Gly Leu Leu 
945                 950                 955                 960 


Leu Leu Ala Val Leu Val Phe Val Met Tyr Arg Met Gly Phe Phe Lys 
                965                 970                 975     


Arg Val Arg Pro Pro Gln Glu Glu Gln Glu Arg Glu Gln Leu Gln Pro 
            980                 985                 990         


His Glu Asn Gly Glu Gly Asn Ser  Glu Thr 
        995                 1000         


<210>  5622
<211>  1163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGAX__Homo_sapiens__NP_000878

<400>  5622

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Ser Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Ala 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser His Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Pro  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Ser Glu Lys 
    1160             


<210>  5623
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB1BP1__Homo_sapiens__NP_004754

<400>  5623

Met Phe Arg Lys Gly Lys Lys Arg His Ser Ser Ser Ser Ser Gln Ser 
1               5                   10                  15      


Ser Glu Ile Ser Thr Lys Ser Lys Ser Val Asp Ser Ser Leu Gly Gly 
            20                  25                  30          


Leu Ser Arg Ser Ser Thr Val Ala Ser Leu Asp Thr Asp Ser Thr Lys 
        35                  40                  45              


Ser Ser Gly Gln Ser Asn Asn Asn Ser Asp Thr Cys Ala Glu Phe Arg 
    50                  55                  60                  


Ile Lys Tyr Val Gly Ala Ile Glu Lys Leu Lys Leu Ser Glu Gly Lys 
65                  70                  75                  80  


Gly Leu Glu Gly Pro Leu Asp Leu Ile Asn Tyr Ile Asp Val Ala Gln 
                85                  90                  95      


Gln Asp Gly Lys Leu Pro Phe Val Pro Pro Glu Glu Glu Phe Ile Met 
            100                 105                 110         


Gly Val Ser Lys Tyr Gly Ile Lys Val Ser Thr Ser Asp Gln Tyr Asp 
        115                 120                 125             


Val Leu His Arg His Ala Leu Tyr Leu Ile Ile Arg Met Val Cys Tyr 
    130                 135                 140                 


Asp Asp Gly Leu Gly Ala Gly Lys Ser Leu Leu Ala Leu Lys Thr Thr 
145                 150                 155                 160 


Asp Ala Ser Asn Glu Glu Tyr Ser Leu Trp Val Tyr Gln Cys Asn Ser 
                165                 170                 175     


Leu Glu Gln Ala Gln Ala Ile Cys Lys Val Leu Ser Thr Ala Phe Asp 
            180                 185                 190         


Ser Val Leu Thr Ser Glu Lys Pro 
        195                 200 


<210>  5624
<211>  801
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB1__Homo_sapiens__NP_391988

<400>  5624

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gln Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Pro Ile Asn Asn Phe Lys Asn Pro Asn Tyr Gly Arg Lys Ala Gly 
785                 790                 795                 800 


Leu 
    


<210>  5625
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB2__Homo_sapiens__NP_000202

<400>  5625

Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      


Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          


Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              


Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  


Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  


Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      


Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         


Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 


Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 


Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     


Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         


Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             


Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 


Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 


Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     


Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         


Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             


Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 


Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 


Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     


Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         


Val His Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             


Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 


Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 


Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     


Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         


Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             


Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 


Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 


Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     


Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         


Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             


Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 


Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 


Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     


Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         


Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             


Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 


Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 


Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     


Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         


Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             


Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 


Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 


Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     


Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         


Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             


Ser 
    


<210>  5626
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB3__Homo_sapiens__NP_000203

<400>  5626

Met Arg Ala Arg Pro Arg Pro Arg Pro Leu Trp Ala Thr Val Leu Ala 
1               5                   10                  15      


Leu Gly Ala Leu Ala Gly Val Gly Val Gly Gly Pro Asn Ile Cys Thr 
            20                  25                  30          


Thr Arg Gly Val Ser Ser Cys Gln Gln Cys Leu Ala Val Ser Pro Met 
        35                  40                  45              


Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro Leu Gly Ser Pro Arg Cys 
    50                  55                  60                  


Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn Cys Ala Pro Glu Ser Ile 
65                  70                  75                  80  


Glu Phe Pro Val Ser Glu Ala Arg Val Leu Glu Asp Arg Pro Leu Ser 
                85                  90                  95      


Asp Lys Gly Ser Gly Asp Ser Ser Gln Val Thr Gln Val Ser Pro Gln 
            100                 105                 110         


Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp Ser Lys Asn Phe Ser Ile 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Ile Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Trp Ser Ile Gln Asn Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Thr Gln Met Arg Lys Leu Thr Ser Asn Leu Arg 
                165                 170                 175     


Ile Gly Phe Gly Ala Phe Val Asp Lys Pro Val Ser Pro Tyr Met Tyr 
            180                 185                 190         


Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro Cys Tyr Asp Met Lys Thr 
        195                 200                 205             


Thr Cys Leu Pro Met Phe Gly Tyr Lys His Val Leu Thr Leu Thr Asp 
    210                 215                 220                 


Gln Val Thr Arg Phe Asn Glu Glu Val Lys Lys Gln Ser Val Ser Arg 
225                 230                 235                 240 


Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Ala Thr 
                245                 250                 255     


Val Cys Asp Glu Lys Ile Gly Trp Arg Asn Asp Ala Ser His Leu Leu 
            260                 265                 270         


Val Phe Thr Thr Asp Ala Lys Thr His Ile Ala Leu Asp Gly Arg Leu 
        275                 280                 285             


Ala Gly Ile Val Gln Pro Asn Asp Gly Gln Cys His Val Gly Ser Asp 
    290                 295                 300                 


Asn His Tyr Ser Ala Ser Thr Thr Met Asp Tyr Pro Ser Leu Gly Leu 
305                 310                 315                 320 


Met Thr Glu Lys Leu Ser Gln Lys Asn Ile Asn Leu Ile Phe Ala Val 
                325                 330                 335     


Thr Glu Asn Val Val Asn Leu Tyr Gln Asn Tyr Ser Glu Leu Ile Pro 
            340                 345                 350         


Gly Thr Thr Val Gly Val Leu Ser Met Asp Ser Ser Asn Val Leu Gln 
        355                 360                 365             


Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg Ser Lys Val Glu Leu Glu 
    370                 375                 380                 


Val Arg Asp Leu Pro Glu Glu Leu Ser Leu Ser Phe Asn Ala Thr Cys 
385                 390                 395                 400 


Leu Asn Asn Glu Val Ile Pro Gly Leu Lys Ser Cys Met Gly Leu Lys 
                405                 410                 415     


Ile Gly Asp Thr Val Ser Phe Ser Ile Glu Ala Lys Val Arg Gly Cys 
            420                 425                 430         


Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile Lys Pro Val Gly Phe Lys 
        435                 440                 445             


Asp Ser Leu Ile Val Gln Val Thr Phe Asp Cys Asp Cys Ala Cys Gln 
    450                 455                 460                 


Ala Gln Ala Glu Pro Asn Ser His Arg Cys Asn Asn Gly Asn Gly Thr 
465                 470                 475                 480 


Phe Glu Cys Gly Val Cys Arg Cys Gly Pro Gly Trp Leu Gly Ser Gln 
                485                 490                 495     


Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro Ser Gln Gln Asp Glu Cys 
            500                 505                 510         


Ser Pro Arg Glu Gly Gln Pro Val Cys Ser Gln Arg Gly Glu Cys Leu 
        515                 520                 525             


Cys Gly Gln Cys Val Cys His Ser Ser Asp Phe Gly Lys Ile Thr Gly 
    530                 535                 540                 


Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys Val Arg Tyr Lys Gly Glu 
545                 550                 555                 560 


Met Cys Ser Gly His Gly Gln Cys Ser Cys Gly Asp Cys Leu Cys Asp 
                565                 570                 575     


Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys Thr Thr Arg Thr Asp Thr 
            580                 585                 590         


Cys Met Ser Ser Asn Gly Leu Leu Cys Ser Gly Arg Gly Lys Cys Glu 
        595                 600                 605             


Cys Gly Ser Cys Val Cys Ile Gln Pro Gly Ser Tyr Gly Asp Thr Cys 
    610                 615                 620                 


Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Thr Phe Lys Lys Glu Cys 
625                 630                 635                 640 


Val Glu Cys Lys Lys Phe Asp Arg Gly Ala Leu His Asp Glu Asn Thr 
                645                 650                 655     


Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu Ser Val Lys Glu Leu Lys 
            660                 665                 670         


Asp Thr Gly Lys Asp Ala Val Asn Cys Thr Tyr Lys Asn Glu Asp Asp 
        675                 680                 685             


Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile 
    690                 695                 700                 


Leu Tyr Val Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp Ile Leu 
705                 710                 715                 720 


Val Val Leu Leu Ser Val Met Gly Ala Ile Leu Leu Ile Gly Leu Ala 
                725                 730                 735     


Ala Leu Leu Ile Trp Lys Leu Leu Ile Thr Ile His Asp Arg Lys Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Glu Glu Arg Ala Arg Ala Lys Trp Asp Thr Ala 
        755                 760                 765             


Asn Asn Pro Leu Tyr Lys Glu Ala Thr Ser Thr Phe Thr Asn Ile Thr 
    770                 775                 780                 


Tyr Arg Gly Thr 
785             


<210>  5627
<211>  1822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB4__Homo_sapiens__NP_000204

<400>  5627

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Gly  Cys Gly Trp Lys Phe  Glu Pro Leu Leu Gly  Glu Glu Leu 
    1370                 1375                 1380             


Asp Leu  Arg Arg Val Thr Trp  Arg Leu Pro Pro Glu  Leu Ile Pro 
    1385                 1390                 1395             


Arg Leu  Ser Ala Ser Ser Gly  Arg Ser Ser Asp Ala  Glu Ala Pro 
    1400                 1405                 1410             


His Gly  Pro Pro Asp Asp Gly  Gly Ala Gly Gly Lys  Gly Gly Ser 
    1415                 1420                 1425             


Leu Pro  Arg Ser Ala Thr Pro  Gly Pro Pro Gly Glu  His Leu Val 
    1430                 1435                 1440             


Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly Ser Thr  Asn Ser Leu 
    1445                 1450                 1455             


His Arg  Met Thr Thr Thr Ser  Ala Ala Ala Tyr Gly  Thr His Leu 
    1460                 1465                 1470             


Ser Pro  His Val Pro His Arg  Val Leu Ser Thr Ser  Ser Thr Leu 
    1475                 1480                 1485             


Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser Glu His  Ser His Ser 
    1490                 1495                 1500             


Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu Thr Ser  Val Ser Ser 
    1505                 1510                 1515             


His Asp  Ser Arg Leu Thr Ala  Gly Val Pro Asp Thr  Pro Thr Arg 
    1520                 1525                 1530             


Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser Leu Arg  Val Ser Trp 
    1535                 1540                 1545             


Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln Gly Tyr  Ser Val Glu 
    1550                 1555                 1560             


Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His Arg Leu  Asn Ile Pro 
    1565                 1570                 1575             


Asn Pro  Ala Gln Thr Ser Val  Val Val Glu Asp Leu  Leu Pro Asn 
    1580                 1585                 1590             


His Ser  Tyr Val Phe Arg Val  Arg Ala Gln Ser Gln  Glu Gly Trp 
    1595                 1600                 1605             


Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile Glu Ser  Gln Val His 
    1610                 1615                 1620             


Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly Ser Ala  Phe Thr Leu 
    1625                 1630                 1635             


Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val Phe Thr  Ala Leu Ser 
    1640                 1645                 1650             


Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg Pro Arg  Arg Pro Asn 
    1655                 1660                 1665             


Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys Glu Met  Ala Gln Gly 
    1670                 1675                 1680             


Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp Gly Asp  Ser Pro Glu 
    1685                 1690                 1695             


Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu Asn Val  Pro Tyr Lys 
    1700                 1705                 1710             


Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly Phe Gly  Pro Glu Arg 
    1715                 1720                 1725             


Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp Gly Gly  Pro Phe Pro 
    1730                 1735                 1740             


Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln His Pro  Leu Gln Ser 
    1745                 1750                 1755             


Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr Ser Ala  Thr Glu Pro 
    1760                 1765                 1770             


Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala Gln His  Leu Glu Ala 
    1775                 1780                 1785             


Gly Gly  Ser Leu Thr Arg His  Val Thr Gln Glu Phe  Val Ser Arg 
    1790                 1795                 1800             


Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr His Met  Asp Gln Gln 
    1805                 1810                 1815             


Phe Phe  Gln Thr 
    1820         


<210>  5628
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB5__Homo_sapiens__NP_002204

<400>  5628

Met Pro Arg Ala Pro Ala Pro Leu Tyr Ala Cys Leu Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Leu Pro Arg Leu Ala Gly Leu Asn Ile Cys Thr Ser Gly Ser 
            20                  25                  30          


Ala Thr Ser Cys Glu Glu Cys Leu Leu Ile His Pro Lys Cys Ala Trp 
        35                  40                  45              


Cys Ser Lys Glu Asp Phe Gly Ser Pro Arg Ser Ile Thr Ser Arg Cys 
    50                  55                  60                  


Asp Leu Arg Ala Asn Leu Val Lys Asn Gly Cys Gly Gly Glu Ile Glu 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Phe His Val Leu Arg Ser Leu Pro Leu Ser Ser 
                85                  90                  95      


Lys Gly Ser Gly Ser Ala Gly Trp Asp Val Ile Gln Met Thr Pro Gln 
            100                 105                 110         


Glu Ile Ala Val Asn Leu Arg Pro Gly Asp Lys Thr Thr Phe Gln Leu 
        115                 120                 125             


Gln Val Arg Gln Val Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met 
    130                 135                 140                 


Asp Leu Ser Leu Ser Met Lys Asp Asp Leu Asp Asn Ile Arg Ser Leu 
145                 150                 155                 160 


Gly Thr Lys Leu Ala Glu Glu Met Arg Lys Leu Thr Ser Asn Phe Arg 
                165                 170                 175     


Leu Gly Phe Gly Ser Phe Val Asp Lys Asp Ile Ser Pro Phe Ser Tyr 
            180                 185                 190         


Thr Ala Pro Arg Tyr Gln Thr Asn Pro Cys Ile Gly Tyr Lys Leu Phe 
        195                 200                 205             


Pro Asn Cys Val Pro Ser Phe Gly Phe Arg His Leu Leu Pro Leu Thr 
    210                 215                 220                 


Asp Arg Val Asp Ser Phe Asn Glu Glu Val Arg Lys Gln Arg Val Ser 
225                 230                 235                 240 


Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp Ala Val Leu Gln Ala 
                245                 250                 255     


Ala Val Cys Lys Glu Lys Ile Gly Trp Arg Lys Asp Ala Leu His Leu 
            260                 265                 270         


Leu Val Phe Thr Thr Asp Asp Val Pro His Ile Ala Leu Asp Gly Lys 
        275                 280                 285             


Leu Gly Gly Leu Val Gln Pro His Asp Gly Gln Cys His Leu Asn Glu 
    290                 295                 300                 


Ala Asn Glu Tyr Thr Ala Ser Asn Gln Met Asp Tyr Pro Ser Leu Ala 
305                 310                 315                 320 


Leu Leu Gly Glu Lys Leu Ala Glu Asn Asn Ile Asn Leu Ile Phe Ala 
                325                 330                 335     


Val Thr Lys Asn His Tyr Met Leu Tyr Lys Asn Phe Thr Ala Leu Ile 
            340                 345                 350         


Pro Gly Thr Thr Val Glu Ile Leu Asp Gly Asp Ser Lys Asn Ile Ile 
        355                 360                 365             


Gln Leu Ile Ile Asn Ala Tyr Asn Ser Ile Arg Ser Lys Val Glu Leu 
    370                 375                 380                 


Ser Val Trp Asp Gln Pro Glu Asp Leu Asn Leu Phe Phe Thr Ala Thr 
385                 390                 395                 400 


Cys Gln Asp Gly Val Ser Tyr Pro Gly Gln Arg Lys Cys Glu Gly Leu 
                405                 410                 415     


Lys Ile Gly Asp Thr Ala Ser Phe Glu Val Ser Leu Glu Ala Arg Ser 
            420                 425                 430         


Cys Pro Ser Arg His Thr Glu His Val Phe Ala Leu Arg Pro Val Gly 
        435                 440                 445             


Phe Arg Asp Ser Leu Glu Val Gly Val Thr Tyr Asn Cys Thr Cys Gly 
    450                 455                 460                 


Cys Ser Val Gly Leu Glu Pro Asn Ser Ala Arg Cys Asn Gly Ser Gly 
465                 470                 475                 480 


Thr Tyr Val Cys Gly Leu Cys Glu Cys Ser Pro Gly Tyr Leu Gly Thr 
                485                 490                 495     


Arg Cys Glu Cys Gln Asp Gly Glu Asn Gln Ser Val Tyr Gln Asn Leu 
            500                 505                 510         


Cys Arg Glu Ala Glu Gly Lys Pro Leu Cys Ser Gly Arg Gly Asp Cys 
        515                 520                 525             


Ser Cys Asn Gln Cys Ser Cys Phe Glu Ser Glu Phe Gly Lys Ile Tyr 
    530                 535                 540                 


Gly Pro Phe Cys Glu Cys Asp Asn Phe Ser Cys Ala Arg Asn Lys Gly 
545                 550                 555                 560 


Val Leu Cys Ser Gly His Gly Glu Cys His Cys Gly Glu Cys Lys Cys 
                565                 570                 575     


His Ala Gly Tyr Ile Gly Asp Asn Cys Asn Cys Ser Thr Asp Ile Ser 
            580                 585                 590         


Thr Cys Arg Gly Arg Asp Gly Gln Ile Cys Ser Glu Arg Gly His Cys 
        595                 600                 605             


Leu Cys Gly Gln Cys Gln Cys Thr Glu Pro Gly Ala Phe Gly Glu Met 
    610                 615                 620                 


Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys Ser Thr Lys Arg Asp 
625                 630                 635                 640 


Cys Val Glu Cys Leu Leu Leu His Ser Gly Lys Pro Asp Asn Gln Thr 
                645                 650                 655     


Cys His Ser Leu Cys Arg Asp Glu Val Ile Thr Trp Val Asp Thr Ile 
            660                 665                 670         


Val Lys Asp Asp Gln Glu Ala Val Leu Cys Phe Tyr Lys Thr Ala Lys 
        675                 680                 685             


Asp Cys Val Met Met Phe Thr Tyr Val Glu Leu Pro Ser Gly Lys Ser 
    690                 695                 700                 


Asn Leu Thr Val Leu Arg Glu Pro Glu Cys Gly Asn Thr Pro Asn Ala 
705                 710                 715                 720 


Met Thr Ile Leu Leu Ala Val Val Gly Ser Ile Leu Leu Val Gly Leu 
                725                 730                 735     


Ala Leu Leu Ala Ile Trp Lys Leu Leu Val Thr Ile His Asp Arg Arg 
            740                 745                 750         


Glu Phe Ala Lys Phe Gln Ser Glu Arg Ser Arg Ala Arg Tyr Glu Met 
        755                 760                 765             


Ala Ser Asn Pro Leu Tyr Arg Lys Pro Ile Ser Thr His Thr Val Asp 
    770                 775                 780                 


Phe Thr Phe Asn Lys Phe Asn Lys Ser Tyr Asn Gly Thr Val Asp 
785                 790                 795                 


<210>  5629
<211>  788
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB6__Homo_sapiens__NP_000879

<400>  5629

Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      


Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          


Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              


Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  


Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  


Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      


Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         


Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             


Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 


Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 


Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         


Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             


Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 


Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     


Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         


Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             


Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 


Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 


Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     


Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         


Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             


Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 


Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 


Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     


Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         


Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             


Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 


Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 


Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     


Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         


Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             


Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 


Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 


Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     


Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         


Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             


Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 


Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 


Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     


Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         


Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             


Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 


Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 


Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     


His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         


Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             


Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 


Ser Thr Asp Cys 
785             


<210>  5630
<211>  798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB7__Homo_sapiens__NP_000880

<400>  5630

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         


Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             


Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 


Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 


Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     


Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         


Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             


Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 


Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 


Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     


Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         


Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             


Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 


Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 


Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     


Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         


Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             


Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 


Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             


<210>  5631
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGB8__Homo_sapiens__NP_002205

<400>  5631

Met Cys Gly Ser Ala Leu Ala Phe Phe Thr Ala Ala Phe Val Cys Leu 
1               5                   10                  15      


Gln Asn Asp Arg Arg Gly Pro Ala Ser Phe Leu Trp Ala Ala Trp Val 
            20                  25                  30          


Phe Ser Leu Val Leu Gly Leu Gly Gln Gly Glu Asp Asn Arg Cys Ala 
        35                  40                  45              


Ser Ser Asn Ala Ala Ser Cys Ala Arg Cys Leu Ala Leu Gly Pro Glu 
    50                  55                  60                  


Cys Gly Trp Cys Val Gln Glu Asp Phe Ile Ser Gly Gly Ser Arg Ser 
65                  70                  75                  80  


Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly Cys Ser Val 
                85                  90                  95      


Asp Ser Ile Glu Tyr Pro Ser Val His Val Ile Ile Pro Thr Glu Asn 
            100                 105                 110         


Glu Ile Asn Thr Gln Val Thr Pro Gly Glu Val Ser Ile Gln Leu Arg 
        115                 120                 125             


Pro Gly Ala Glu Ala Asn Phe Met Leu Lys Val His Pro Leu Lys Lys 
    130                 135                 140                 


Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala Ser Met His 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu Ser Arg Lys 
                165                 170                 175     


Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly Ser Tyr Val 
            180                 185                 190         


Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu Arg Ile His 
        195                 200                 205             


Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro His Gly Tyr 
    210                 215                 220                 


Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe Glu Lys Ala 
225                 230                 235                 240 


Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro Glu Gly Gly 
                245                 250                 255     


Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His Ile Gly Trp 
            260                 265                 270         


Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp Gln Thr Ser 
        275                 280                 285             


His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val Pro Asn Asp 
    290                 295                 300                 


Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser Thr Thr Met 
305                 310                 315                 320 


Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile Asp Asn Asn 
                325                 330                 335     


Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His Trp Tyr Lys 
            340                 345                 350         


Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu Ile Glu Ser 
        355                 360                 365             


Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Val Lys Val Gln Val Glu Asn Gln Val Gln Gly Ile Tyr 
385                 390                 395                 400 


Phe Asn Ile Thr Ala Ile Cys Pro Asp Gly Ser Arg Lys Pro Gly Met 
                405                 410                 415     


Glu Gly Cys Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val 
            420                 425                 430         


Thr Val Thr Met Lys Lys Cys Asp Val Thr Gly Gly Lys Asn Tyr Ala 
        435                 440                 445             


Ile Ile Lys Pro Ile Gly Phe Asn Glu Thr Ala Lys Ile His Ile His 
    450                 455                 460                 


Arg Asn Cys Ser Cys Gln Cys Glu Asp Asn Arg Gly Pro Lys Gly Lys 
465                 470                 475                 480 


Cys Val Asp Glu Thr Phe Leu Asp Ser Lys Cys Phe Gln Cys Asp Glu 
                485                 490                 495     


Asn Lys Cys His Phe Asp Glu Asp Gln Phe Ser Ser Glu Ser Cys Lys 
            500                 505                 510         


Ser His Lys Asp Gln Pro Val Cys Ser Gly Arg Gly Val Cys Val Cys 
        515                 520                 525             


Gly Lys Cys Ser Cys His Lys Ile Lys Leu Gly Lys Val Tyr Gly Lys 
    530                 535                 540                 


Tyr Cys Glu Lys Asp Asp Phe Ser Cys Pro Tyr His His Gly Asn Leu 
545                 550                 555                 560 


Cys Ala Gly His Gly Glu Cys Glu Ala Gly Arg Cys Gln Cys Phe Ser 
                565                 570                 575     


Gly Trp Glu Gly Asp Arg Cys Gln Cys Pro Ser Ala Ala Ala Gln His 
            580                 585                 590         


Cys Val Asn Ser Lys Gly Gln Val Cys Ser Gly Arg Gly Thr Cys Val 
        595                 600                 605             


Cys Gly Arg Cys Glu Cys Thr Asp Pro Arg Ser Ile Gly Arg Phe Cys 
    610                 615                 620                 


Glu His Cys Pro Thr Cys Tyr Thr Ala Cys Lys Glu Asn Trp Asn Cys 
625                 630                 635                 640 


Met Gln Cys Leu His Pro His Asn Leu Ser Gln Ala Ile Leu Asp Gln 
                645                 650                 655     


Cys Lys Thr Ser Cys Ala Leu Met Glu Gln Gln His Tyr Val Asp Gln 
            660                 665                 670         


Thr Ser Glu Cys Phe Ser Ser Pro Ser Tyr Leu Arg Ile Phe Phe Ile 
        675                 680                 685             


Ile Phe Ile Val Thr Phe Leu Ile Gly Leu Leu Lys Val Leu Ile Ile 
    690                 695                 700                 


Arg Gln Val Ile Leu Gln Trp Asn Ser Asn Lys Ile Lys Ser Ser Ser 
705                 710                 715                 720 


Asp Tyr Arg Val Ser Ala Ser Lys Lys Asp Lys Leu Ile Leu Gln Ser 
                725                 730                 735     


Val Cys Thr Arg Ala Val Thr Tyr Arg Arg Glu Lys Pro Glu Glu Ile 
            740                 745                 750         


Lys Met Asp Ile Ser Lys Leu Asn Ala His Glu Thr Phe Arg Cys Asn 
        755                 760                 765             


Phe 
    


<210>  5632
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITGBL1__Homo_sapiens__NP_001258683

<400>  5632

Met Cys Lys Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys 
1               5                   10                  15      


His Cys Gly Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val 
            20                  25                  30          


Tyr Gly Lys Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu 
        35                  40                  45              


Thr Glu Glu Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys 
    50                  55                  60                  


Tyr Cys Lys Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp 
65                  70                  75                  80  


Ile Thr Pro Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys 
                85                  90                  95      


Ile Cys Ser Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His 
            100                 105                 110         


Asp Val Asp Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys 
        115                 120                 125             


Glu Cys Asp Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp 
    130                 135                 140                 


Asp Phe Cys Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys 
145                 150                 155                 160 


Lys Ala Gly Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr 
                165                 170                 175     


Leu Ser Ala Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu 
            180                 185                 190         


Pro Cys Ser Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr 
        195                 200                 205             


Pro Pro Gly Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp 
    210                 215                 220                 


Arg Arg Cys Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr 
225                 230                 235                 240 


Cys Ser Cys Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu 
                245                 250                 255     


Cys Gln His Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn 
            260                 265                 270         


Leu Cys Glu Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys 
        275                 280                 285             


His Cys Gly Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly 
    290                 295                 300                 


Glu Phe Cys Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu 
305                 310                 315                 320 


Ile Cys Thr Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp 
                325                 330                 335     


Asp Gly Trp Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr 
            340                 345                 350         


Pro 
    


<210>  5633
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIH1__Homo_sapiens__NP_002206

<400>  5633

Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu 
1               5                   10                  15      


Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 
            20                  25                  30          


Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 
        35                  40                  45              


Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 
    50                  55                  60                  


Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn 
65                  70                  75                  80  


Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe 
                85                  90                  95      


Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp 
            100                 105                 110         


Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile 
        115                 120                 125             


Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu 
    130                 135                 140                 


Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe 
145                 150                 155                 160 


Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 
                165                 170                 175     


Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile 
            180                 185                 190         


Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln 
        195                 200                 205             


Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser 
    210                 215                 220                 


Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln 
225                 230                 235                 240 


Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe 
                245                 250                 255     


Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val 
            260                 265                 270         


Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn 
        275                 280                 285             


Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 
    290                 295                 300                 


Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 
305                 310                 315                 320 


Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 
            340                 345                 350         


Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 
        355                 360                 365             


Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 
    370                 375                 380                 


Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 
385                 390                 395                 400 


Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 
                405                 410                 415     


Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 
            420                 425                 430         


Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 
        435                 440                 445             


Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 
    450                 455                 460                 


Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 
465                 470                 475                 480 


Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 
                485                 490                 495     


Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 
            500                 505                 510         


Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 
        515                 520                 525             


Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 
    530                 535                 540                 


Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 
545                 550                 555                 560 


His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 
                565                 570                 575     


Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 
            580                 585                 590         


Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 
        595                 600                 605             


Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 
    610                 615                 620                 


Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 
625                 630                 635                 640 


Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 
                645                 650                 655     


Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 
            660                 665                 670         


Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 
        675                 680                 685             


Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 
    690                 695                 700                 


Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 
705                 710                 715                 720 


Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 
                725                 730                 735     


Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 
            740                 745                 750         


Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 
        755                 760                 765             


Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 
    770                 775                 780                 


Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 
785                 790                 795                 800 


Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 
                805                 810                 815     


Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 
            820                 825                 830         


Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 
        835                 840                 845             


Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 
    850                 855                 860                 


Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 
865                 870                 875                 880 


His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 
                885                 890                 895     


Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 
            900                 905                 910     


<210>  5634
<211>  946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIH2__Homo_sapiens__NP_002207

<400>  5634

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 
    50                  55                  60                  


Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 
                85                  90                  95      


Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys 
            100                 105                 110         


Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe 
        115                 120                 125             


Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln 
    130                 135                 140                 


Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu 
145                 150                 155                 160 


Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys 
                165                 170                 175     


Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 
            180                 185                 190         


Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 
        195                 200                 205             


Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 
    210                 215                 220                 


His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala 
                245                 250                 255     


Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr Ala Val Asp Gly Glu 
            260                 265                 270         


Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu 
        275                 280                 285             


Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 
    290                 295                 300                 


Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 
305                 310                 315                 320 


Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile 
                325                 330                 335     


Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn 
            340                 345                 350         


Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr 
        355                 360                 365             


Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly 
    370                 375                 380                 


Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn 
385                 390                 395                 400 


Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 
                405                 410                 415     


Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 
            420                 425                 430         


Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 
        435                 440                 445             


Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg 
    450                 455                 460                 


Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln 
465                 470                 475                 480 


Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro 
                485                 490                 495     


Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp 
            500                 505                 510         


Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val 
        515                 520                 525             


Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 
    530                 535                 540                 


Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 
545                 550                 555                 560 


Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 
                565                 570                 575     


Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu 
            580                 585                 590         


Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile 
        595                 600                 605             


Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro 
    610                 615                 620                 


Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu 
625                 630                 635                 640 


Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 
                645                 650                 655     


Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 
            660                 665                 670         


Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 
        675                 680                 685             


Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 
    690                 695                 700                 


Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile 
705                 710                 715                 720 


Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser 
                725                 730                 735     


Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn 
            740                 745                 750         


Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser 
        755                 760                 765             


Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His 
    770                 775                 780                 


Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 
785                 790                 795                 800 


Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 
                805                 810                 815     


Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp 
            820                 825                 830         


Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro 
        835                 840                 845             


Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met 
    850                 855                 860                 


Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro 
865                 870                 875                 880 


Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile 
                885                 890                 895     


Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 
            900                 905                 910         


Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 
        915                 920                 925             


Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 
    930                 935                 940                 


Arg Pro 
945     


<210>  5635
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIH3__Homo_sapiens__NP_002208

<400>  5635

Met Ala Phe Ala Trp Trp Pro Cys Leu Ile Leu Ala Leu Leu Ser Ser 
1               5                   10                  15      


Leu Ala Ala Ser Gly Phe Pro Arg Ser Pro Phe Arg Leu Leu Gly Lys 
            20                  25                  30          


Arg Ser Leu Pro Glu Gly Val Ala Asn Gly Ile Glu Val Tyr Ser Thr 
        35                  40                  45              


Lys Ile Asn Ser Lys Val Thr Ser Arg Phe Ala His Asn Val Val Thr 
    50                  55                  60                  


Met Arg Ala Val Asn Arg Ala Asp Thr Ala Lys Glu Val Ser Phe Asp 
65                  70                  75                  80  


Val Glu Leu Pro Lys Thr Ala Phe Ile Thr Asn Phe Thr Leu Thr Ile 
                85                  90                  95      


Asp Gly Val Thr Tyr Pro Gly Asn Val Lys Glu Lys Glu Val Ala Lys 
            100                 105                 110         


Lys Gln Tyr Glu Lys Ala Val Ser Gln Gly Lys Thr Ala Gly Leu Val 
        115                 120                 125             


Lys Ala Ser Gly Arg Lys Leu Glu Lys Phe Thr Val Ser Val Asn Val 
    130                 135                 140                 


Ala Ala Gly Ser Lys Val Thr Phe Glu Leu Thr Tyr Glu Glu Leu Leu 
145                 150                 155                 160 


Lys Arg His Lys Gly Lys Tyr Glu Met Tyr Leu Lys Val Gln Pro Lys 
                165                 170                 175     


Gln Leu Val Lys His Phe Glu Ile Glu Val Asp Ile Phe Glu Pro Gln 
            180                 185                 190         


Gly Ile Ser Met Leu Asp Ala Glu Ala Ser Phe Ile Thr Asn Asp Leu 
        195                 200                 205             


Leu Gly Ser Ala Leu Thr Lys Ser Phe Ser Gly Lys Lys Gly His Val 
    210                 215                 220                 


Ser Phe Lys Pro Ser Leu Asp Gln Gln Arg Ser Cys Pro Thr Cys Thr 
225                 230                 235                 240 


Asp Ser Leu Leu Asn Gly Asp Phe Thr Ile Thr Tyr Asp Val Asn Arg 
                245                 250                 255     


Glu Ser Pro Gly Asn Val Gln Ile Val Asn Gly Tyr Phe Val His Phe 
            260                 265                 270         


Phe Ala Pro Gln Gly Leu Pro Val Val Pro Lys Asn Val Ala Phe Val 
        275                 280                 285             


Ile Asp Ile Ser Gly Ser Met Ala Gly Arg Lys Leu Glu Gln Thr Lys 
    290                 295                 300                 


Glu Ala Leu Leu Arg Ile Leu Glu Asp Met Gln Glu Glu Asp Tyr Leu 
305                 310                 315                 320 


Asn Phe Ile Leu Phe Ser Gly Asp Val Ser Thr Trp Lys Glu His Leu 
                325                 330                 335     


Val Gln Ala Thr Pro Glu Asn Leu Gln Glu Ala Arg Thr Phe Val Lys 
            340                 345                 350         


Ser Met Glu Asp Lys Gly Met Thr Asn Ile Asn Asp Gly Leu Leu Arg 
        355                 360                 365             


Gly Ile Ser Met Leu Asn Lys Ala Arg Glu Glu His Arg Ile Pro Glu 
    370                 375                 380                 


Arg Ser Thr Ser Ile Val Ile Met Leu Thr Asp Gly Asp Ala Asn Val 
385                 390                 395                 400 


Gly Glu Ser Arg Pro Glu Lys Ile Gln Glu Asn Val Arg Asn Ala Ile 
                405                 410                 415     


Gly Gly Lys Phe Pro Leu Tyr Asn Leu Gly Phe Gly Asn Asn Leu Asn 
            420                 425                 430         


Tyr Asn Phe Leu Glu Asn Met Ala Leu Glu Asn His Gly Phe Ala Arg 
        435                 440                 445             


Arg Ile Tyr Glu Asp Ser Asp Ala Asp Leu Gln Leu Gln Gly Phe Tyr 
    450                 455                 460                 


Glu Glu Val Ala Asn Pro Leu Leu Thr Gly Val Glu Met Glu Tyr Pro 
465                 470                 475                 480 


Glu Asn Ala Ile Leu Asp Leu Thr Gln Asn Thr Tyr Gln His Phe Tyr 
                485                 490                 495     


Asp Gly Ser Glu Ile Val Val Ala Gly Arg Leu Val Asp Glu Asp Met 
            500                 505                 510         


Asn Ser Phe Lys Ala Asp Val Lys Gly His Gly Ala Thr Asn Asp Leu 
        515                 520                 525             


Thr Phe Thr Glu Glu Val Asp Met Lys Glu Met Glu Lys Ala Leu Gln 
    530                 535                 540                 


Glu Arg Asp Tyr Ile Phe Gly Asn Tyr Ile Glu Arg Leu Trp Ala Tyr 
545                 550                 555                 560 


Leu Thr Ile Glu Gln Leu Leu Glu Lys Arg Lys Asn Ala His Gly Glu 
                565                 570                 575     


Glu Lys Glu Asn Leu Thr Ala Arg Ala Leu Asp Leu Ser Leu Lys Tyr 
            580                 585                 590         


His Phe Val Thr Pro Leu Thr Ser Met Val Val Thr Lys Pro Glu Asp 
        595                 600                 605             


Asn Glu Asp Glu Arg Ala Ile Ala Asp Lys Pro Gly Glu Asp Ala Glu 
    610                 615                 620                 


Ala Thr Pro Val Ser Pro Ala Met Ser Tyr Leu Thr Ser Tyr Gln Pro 
625                 630                 635                 640 


Pro Gln Asn Pro Tyr Tyr Tyr Val Asp Gly Asp Pro His Phe Ile Ile 
                645                 650                 655     


Gln Ile Pro Glu Lys Asp Asp Ala Leu Cys Phe Asn Ile Asp Glu Ala 
            660                 665                 670         


Pro Gly Thr Val Leu Arg Leu Ile Gln Asp Ala Val Thr Gly Leu Thr 
        675                 680                 685             


Val Asn Gly Gln Ile Thr Gly Asp Lys Arg Gly Ser Pro Asp Ser Lys 
    690                 695                 700                 


Thr Arg Lys Thr Tyr Phe Gly Lys Leu Gly Ile Ala Asn Ala Gln Met 
705                 710                 715                 720 


Asp Phe Gln Val Glu Val Thr Thr Glu Lys Ile Thr Leu Trp Asn Arg 
                725                 730                 735     


Ala Val Pro Ser Thr Phe Ser Trp Leu Asp Thr Val Thr Val Thr Gln 
            740                 745                 750         


Asp Gly Leu Ser Met Met Ile Asn Arg Lys Asn Met Val Val Ser Phe 
        755                 760                 765             


Gly Asp Gly Val Thr Phe Val Val Val Leu His Gln Val Trp Lys Lys 
    770                 775                 780                 


His Pro Val His Arg Asp Phe Leu Gly Phe Tyr Val Val Asp Ser His 
785                 790                 795                 800 


Arg Met Ser Ala Gln Thr His Gly Leu Leu Gly Gln Phe Phe Gln Pro 
                805                 810                 815     


Phe Asp Phe Lys Val Ser Asp Ile Arg Pro Gly Ser Asp Pro Thr Lys 
            820                 825                 830         


Pro Asp Ala Thr Leu Val Val Lys Asn His Gln Leu Ile Val Thr Arg 
        835                 840                 845             


Gly Ser Gln Lys Asp Tyr Arg Lys Asp Ala Ser Ile Gly Thr Lys Val 
    850                 855                 860                 


Val Cys Trp Phe Val His Asn Asn Gly Glu Gly Leu Ile Asp Gly Val 
865                 870                 875                 880 


His Thr Asp Tyr Ile Val Pro Asn Leu Phe 
                885                 890 


<210>  5636
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIH4__Homo_sapiens__NP_001159921

<400>  5636

Met Lys Pro Pro Arg Pro Val Arg Thr Cys Ser Lys Val Leu Val Leu 
1               5                   10                  15      


Leu Ser Leu Leu Ala Ile His Gln Thr Thr Thr Ala Glu Lys Asn Gly 
            20                  25                  30          


Ile Asp Ile Tyr Ser Leu Thr Val Asp Ser Arg Val Ser Ser Arg Phe 
        35                  40                  45              


Ala His Thr Val Val Thr Ser Arg Val Val Asn Arg Ala Asn Thr Val 
    50                  55                  60                  


Gln Glu Ala Thr Phe Gln Met Glu Leu Pro Lys Lys Ala Phe Ile Thr 
65                  70                  75                  80  


Asn Phe Ser Met Ile Ile Asp Gly Met Thr Tyr Pro Gly Ile Ile Lys 
                85                  90                  95      


Glu Lys Ala Glu Ala Gln Ala Gln Tyr Ser Ala Ala Val Ala Lys Gly 
            100                 105                 110         


Lys Ser Ala Gly Leu Val Lys Ala Thr Gly Arg Asn Met Glu Gln Phe 
        115                 120                 125             


Gln Val Ser Val Ser Val Ala Pro Asn Ala Lys Ile Thr Phe Glu Leu 
    130                 135                 140                 


Val Tyr Glu Glu Leu Leu Lys Arg Arg Leu Gly Val Tyr Glu Leu Leu 
145                 150                 155                 160 


Leu Lys Val Arg Pro Gln Gln Leu Val Lys His Leu Gln Met Asp Ile 
                165                 170                 175     


His Ile Phe Glu Pro Gln Gly Ile Ser Phe Leu Glu Thr Glu Ser Thr 
            180                 185                 190         


Phe Met Thr Asn Gln Leu Val Asp Ala Leu Thr Thr Trp Gln Asn Lys 
        195                 200                 205             


Thr Lys Ala His Ile Arg Phe Lys Pro Thr Leu Ser Gln Gln Gln Lys 
    210                 215                 220                 


Ser Pro Glu Gln Gln Glu Thr Val Leu Asp Gly Asn Leu Ile Ile Arg 
225                 230                 235                 240 


Tyr Asp Val Asp Arg Ala Ile Ser Gly Gly Ser Ile Gln Ile Glu Asn 
                245                 250                 255     


Gly Tyr Phe Val His Tyr Phe Ala Pro Glu Gly Leu Thr Thr Met Pro 
            260                 265                 270         


Lys Asn Val Val Phe Val Ile Asp Lys Ser Gly Ser Met Ser Gly Arg 
        275                 280                 285             


Lys Ile Gln Gln Thr Arg Glu Ala Leu Ile Lys Ile Leu Asp Asp Leu 
    290                 295                 300                 


Ser Pro Arg Asp Gln Phe Asn Leu Ile Val Phe Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Gln Trp Arg Pro Ser Leu Val Pro Ala Ser Ala Glu Asn Val Asn Lys 
                325                 330                 335     


Ala Arg Ser Phe Ala Ala Gly Ile Gln Ala Leu Gly Gly Thr Asn Ile 
            340                 345                 350         


Asn Asp Ala Met Leu Met Ala Val Gln Leu Leu Asp Ser Ser Asn Gln 
        355                 360                 365             


Glu Glu Arg Leu Pro Glu Gly Ser Val Ser Leu Ile Ile Leu Leu Thr 
    370                 375                 380                 


Asp Gly Asp Pro Thr Val Gly Glu Thr Asn Pro Arg Ser Ile Gln Asn 
385                 390                 395                 400 


Asn Val Arg Glu Ala Val Ser Gly Arg Tyr Ser Leu Phe Cys Leu Gly 
                405                 410                 415     


Phe Gly Phe Asp Val Ser Tyr Ala Phe Leu Glu Lys Leu Ala Leu Asp 
            420                 425                 430         


Asn Gly Gly Leu Ala Arg Arg Ile His Glu Asp Ser Asp Ser Ala Leu 
        435                 440                 445             


Gln Leu Gln Asp Phe Tyr Gln Glu Val Ala Asn Pro Leu Leu Thr Ala 
    450                 455                 460                 


Val Thr Phe Glu Tyr Pro Ser Asn Ala Val Glu Glu Val Thr Gln Asn 
465                 470                 475                 480 


Asn Phe Arg Leu Leu Phe Lys Gly Ser Glu Met Val Val Ala Gly Lys 
                485                 490                 495     


Leu Gln Asp Arg Gly Pro Asp Val Leu Thr Ala Thr Val Ser Gly Lys 
            500                 505                 510         


Leu Pro Thr Gln Asn Ile Thr Phe Gln Thr Glu Ser Ser Val Ala Glu 
        515                 520                 525             


Gln Glu Ala Glu Phe Gln Ser Pro Lys Tyr Ile Phe His Asn Phe Met 
    530                 535                 540                 


Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Gln Leu Leu Glu Gln Thr 
545                 550                 555                 560 


Val Ser Ala Ser Asp Ala Asp Gln Gln Ala Leu Arg Asn Gln Ala Leu 
                565                 570                 575     


Asn Leu Ser Leu Ala Tyr Ser Phe Val Thr Pro Leu Thr Ser Met Val 
            580                 585                 590         


Val Thr Lys Pro Asp Asp Gln Glu Gln Ser Gln Val Ala Glu Lys Pro 
        595                 600                 605             


Met Glu Gly Glu Ser Arg Asn Arg Asn Val His Ser Ala Gly Ala Ala 
    610                 615                 620                 


Gly Ser Arg Met Asn Phe Arg Pro Gly Val Leu Ser Ser Arg Gln Leu 
625                 630                 635                 640 


Gly Leu Pro Gly Pro Pro Asp Val Pro Asp His Ala Ala Tyr His Pro 
                645                 650                 655     


Phe Arg Arg Leu Ala Ile Leu Pro Ala Ser Ala Pro Pro Ala Thr Ser 
            660                 665                 670         


Asn Pro Asp Pro Ala Val Ser Arg Val Met Asn Met Lys Ile Glu Glu 
        675                 680                 685             


Thr Thr Met Thr Thr Gln Thr Pro Ala Pro Ile Gln Ala Pro Ser Ala 
    690                 695                 700                 


Ile Leu Pro Leu Pro Gly Gln Ser Val Glu Arg Leu Cys Val Asp Pro 
705                 710                 715                 720 


Arg His Arg Gln Gly Pro Val Asn Leu Leu Ser Asp Pro Glu Gln Gly 
                725                 730                 735     


Val Glu Val Thr Gly Gln Tyr Glu Arg Glu Lys Ala Gly Phe Ser Trp 
            740                 745                 750         


Ile Glu Val Thr Phe Lys Asn Pro Leu Val Trp Val His Ala Ser Pro 
        755                 760                 765             


Glu His Val Val Val Thr Arg Asn Arg Arg Ser Ser Ala Tyr Lys Trp 
    770                 775                 780                 


Lys Glu Thr Leu Phe Ser Val Met Pro Gly Leu Lys Met Thr Met Asp 
785                 790                 795                 800 


Lys Thr Gly Leu Leu Leu Leu Ser Asp Pro Asp Lys Val Thr Ile Gly 
                805                 810                 815     


Leu Leu Phe Trp Asp Gly Arg Gly Glu Gly Leu Arg Leu Leu Leu Arg 
            820                 825                 830         


Asp Thr Asp Arg Phe Ser Ser His Val Gly Gly Thr Leu Gly Gln Phe 
        835                 840                 845             


Tyr Gln Glu Val Leu Trp Gly Ser Pro Ala Ala Ser Asp Asp Gly Arg 
    850                 855                 860                 


Arg Thr Leu Arg Val Gln Gly Asn Asp His Ser Ala Thr Arg Glu Arg 
865                 870                 875                 880 


Arg Leu Asp Tyr Gln Glu Gly Pro Pro Gly Val Glu Ile Ser Cys Trp 
                885                 890                 895     


Ser Val Glu Leu 
            900 


<210>  5637
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIH5__Homo_sapiens__NP_001001851

<400>  5637

Met Leu Leu Leu Leu Gly Leu Cys Leu Gly Leu Ser Leu Cys Val Gly 
1               5                   10                  15      


Ser Gln Glu Glu Ala Gln Ser Trp Gly His Ser Ser Glu Gln Asp Gly 
            20                  25                  30          


Leu Arg Val Pro Arg Gln Val Arg Leu Leu Gln Arg Leu Lys Thr Lys 
        35                  40                  45              


Pro Leu Met Thr Glu Phe Ser Val Lys Ser Thr Ile Ile Ser Arg Tyr 
    50                  55                  60                  


Ala Phe Thr Thr Val Ser Cys Arg Met Leu Asn Arg Ala Ser Glu Asp 
65                  70                  75                  80  


Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala Ala Ala Phe Ile Thr 
                85                  90                  95      


Asn Phe Thr Met Leu Ile Gly Asp Lys Val Tyr Gln Gly Glu Ile Thr 
            100                 105                 110         


Glu Arg Glu Lys Lys Ser Gly Asp Arg Val Lys Glu Lys Arg Asn Lys 
        115                 120                 125             


Thr Thr Glu Glu Asn Gly Glu Lys Gly Thr Glu Ile Phe Arg Ala Ser 
    130                 135                 140                 


Ala Val Ile Pro Ser Lys Asp Lys Ala Ala Phe Phe Leu Ser Tyr Glu 
145                 150                 155                 160 


Glu Leu Leu Gln Arg Arg Leu Gly Lys Tyr Glu His Ser Ile Ser Val 
                165                 170                 175     


Arg Pro Gln Gln Leu Ser Gly Arg Leu Ser Val Asp Val Asn Ile Leu 
            180                 185                 190         


Glu Ser Ala Gly Ile Ala Ser Leu Glu Val Leu Pro Leu His Asn Ser 
        195                 200                 205             


Arg Gln Arg Gly Ser Gly Arg Gly Glu Asp Asp Ser Gly Pro Pro Pro 
    210                 215                 220                 


Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys 
225                 230                 235                 240 


Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln Asn Gly Ile Leu Gly 
                245                 250                 255     


Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu Gln Ser Ile Gly Asp 
            260                 265                 270         


Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro Lys Asp 
        275                 280                 285             


Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val Leu Asp Ser Ser Ala 
    290                 295                 300                 


Ser Met Val Gly Thr Lys Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr 
305                 310                 315                 320 


Ile Leu His Asp Leu Arg Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe 
                325                 330                 335     


Ser Asn Arg Ile Lys Val Trp Lys Asp His Leu Ile Ser Val Thr Pro 
            340                 345                 350         


Asp Ser Ile Arg Asp Gly Lys Val Tyr Ile His His Met Ser Pro Thr 
        355                 360                 365             


Gly Gly Thr Asp Ile Asn Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu 
    370                 375                 380                 


Asn Lys Tyr Val Ala His Ser Gly Ile Gly Asp Arg Ser Val Ser Leu 
385                 390                 395                 400 


Ile Val Phe Leu Thr Asp Gly Lys Pro Thr Val Gly Glu Thr His Thr 
                405                 410                 415     


Leu Lys Ile Leu Asn Asn Thr Arg Glu Ala Ala Arg Gly Gln Val Cys 
            420                 425                 430         


Ile Phe Thr Ile Gly Ile Gly Asn Asp Val Asp Phe Arg Leu Leu Glu 
        435                 440                 445             


Lys Leu Ser Leu Glu Asn Cys Gly Leu Thr Arg Arg Val His Glu Glu 
    450                 455                 460                 


Glu Asp Ala Gly Ser Gln Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr 
465                 470                 475                 480 


Pro Leu Leu Ser Asp Ile Arg Ile Asp Tyr Pro Pro Ser Ser Val Val 
                485                 490                 495     


Gln Ala Thr Lys Thr Leu Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile 
            500                 505                 510         


Ile Ile Ala Gly Lys Leu Val Asp Arg Lys Leu Asp His Leu His Val 
        515                 520                 525             


Glu Val Thr Ala Ser Asn Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp 
    530                 535                 540                 


Val Pro Val Arg Pro Gln Lys Ala Gly Lys Asp Val Thr Gly Ser Pro 
545                 550                 555                 560 


Arg Pro Gly Gly Asp Gly Glu Gly Asp Thr Asn His Ile Glu Arg Leu 
                565                 570                 575     


Trp Ser Tyr Leu Thr Thr Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser 
            580                 585                 590         


Asp Asp Glu Pro Glu Lys Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu 
        595                 600                 605             


Ala Val Ser Tyr Arg Phe Leu Thr Pro Phe Thr Ser Met Lys Leu Arg 
    610                 615                 620                 


Gly Pro Val Pro Arg Met Asp Gly Leu Glu Glu Ala His Gly Met Ser 
625                 630                 635                 640 


Ala Ala Met Gly Pro Glu Pro Val Val Gln Ser Val Arg Gly Ala Gly 
                645                 650                 655     


Thr Gln Pro Gly Pro Leu Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys 
            660                 665                 670         


Ile Ser Lys Thr Ser Val Arg Gly Phe Arg Arg Glu Glu Gln Ile Phe 
        675                 680                 685             


Ser Asn Val Met Lys Phe Pro Phe Ala Ser Ile Leu Glu Leu 
    690                 695                 700         


<210>  5638
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITK__Homo_sapiens__NP_005537

<400>  5638

Met Asn Asn Phe Ile Leu Leu Glu Glu Gln Leu Ile Lys Lys Ser Gln 
1               5                   10                  15      


Gln Lys Arg Arg Thr Ser Pro Ser Asn Phe Lys Val Arg Phe Phe Val 
            20                  25                  30          


Leu Thr Lys Ala Ser Leu Ala Tyr Phe Glu Asp Arg His Gly Lys Lys 
        35                  40                  45              


Arg Thr Leu Lys Gly Ser Ile Glu Leu Ser Arg Ile Lys Cys Val Glu 
    50                  55                  60                  


Ile Val Lys Ser Asp Ile Ser Ile Pro Cys His Tyr Lys Tyr Pro Phe 
65                  70                  75                  80  


Gln Val Val His Asp Asn Tyr Leu Leu Tyr Val Phe Ala Pro Asp Arg 
                85                  90                  95      


Glu Ser Arg Gln Arg Trp Val Leu Ala Leu Lys Glu Glu Thr Arg Asn 
            100                 105                 110         


Asn Asn Ser Leu Val Pro Lys Tyr His Pro Asn Phe Trp Met Asp Gly 
        115                 120                 125             


Lys Trp Arg Cys Cys Ser Gln Leu Glu Lys Leu Ala Thr Gly Cys Ala 
    130                 135                 140                 


Gln Tyr Asp Pro Thr Lys Asn Ala Ser Lys Lys Pro Leu Pro Pro Thr 
145                 150                 155                 160 


Pro Glu Asp Asn Arg Arg Pro Leu Trp Glu Pro Glu Glu Thr Val Val 
                165                 170                 175     


Ile Ala Leu Tyr Asp Tyr Gln Thr Asn Asp Pro Gln Glu Leu Ala Leu 
            180                 185                 190         


Arg Arg Asn Glu Glu Tyr Cys Leu Leu Asp Ser Ser Glu Ile His Trp 
        195                 200                 205             


Trp Arg Val Gln Asp Arg Asn Gly His Glu Gly Tyr Val Pro Ser Ser 
    210                 215                 220                 


Tyr Leu Val Glu Lys Ser Pro Asn Asn Leu Glu Thr Tyr Glu Trp Tyr 
225                 230                 235                 240 


Asn Lys Ser Ile Ser Arg Asp Lys Ala Glu Lys Leu Leu Leu Asp Thr 
                245                 250                 255     


Gly Lys Glu Gly Ala Phe Met Val Arg Asp Ser Arg Thr Ala Gly Thr 
            260                 265                 270         


Tyr Thr Val Ser Val Phe Thr Lys Ala Val Val Ser Glu Asn Asn Pro 
        275                 280                 285             


Cys Ile Lys His Tyr His Ile Lys Glu Thr Asn Asp Asn Pro Lys Arg 
    290                 295                 300                 


Tyr Tyr Val Ala Glu Lys Tyr Val Phe Asp Ser Ile Pro Leu Leu Ile 
305                 310                 315                 320 


Asn Tyr His Gln His Asn Gly Gly Gly Leu Val Thr Arg Leu Arg Tyr 
                325                 330                 335     


Pro Val Cys Phe Gly Arg Gln Lys Ala Pro Val Thr Ala Gly Leu Arg 
            340                 345                 350         


Tyr Gly Lys Trp Val Ile Asp Pro Ser Glu Leu Thr Phe Val Gln Glu 
        355                 360                 365             


Ile Gly Ser Gly Gln Phe Gly Leu Val His Leu Gly Tyr Trp Leu Asn 
    370                 375                 380                 


Lys Asp Lys Val Ala Ile Lys Thr Ile Arg Glu Gly Ala Met Ser Glu 
385                 390                 395                 400 


Glu Asp Phe Ile Glu Glu Ala Glu Val Met Met Lys Leu Ser His Pro 
                405                 410                 415     


Lys Leu Val Gln Leu Tyr Gly Val Cys Leu Glu Gln Ala Pro Ile Cys 
            420                 425                 430         


Leu Val Phe Glu Phe Met Glu His Gly Cys Leu Ser Asp Tyr Leu Arg 
        435                 440                 445             


Thr Gln Arg Gly Leu Phe Ala Ala Glu Thr Leu Leu Gly Met Cys Leu 
    450                 455                 460                 


Asp Val Cys Glu Gly Met Ala Tyr Leu Glu Glu Ala Cys Val Ile His 
465                 470                 475                 480 


Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn Gln Val Ile 
                485                 490                 495     


Lys Val Ser Asp Phe Gly Met Thr Arg Phe Val Leu Asp Asp Gln Tyr 
            500                 505                 510         


Thr Ser Ser Thr Gly Thr Lys Phe Pro Val Lys Trp Ala Ser Pro Glu 
        515                 520                 525             


Val Phe Ser Phe Ser Arg Tyr Ser Ser Lys Ser Asp Val Trp Ser Phe 
    530                 535                 540                 


Gly Val Leu Met Trp Glu Val Phe Ser Glu Gly Lys Ile Pro Tyr Glu 
545                 550                 555                 560 


Asn Arg Ser Asn Ser Glu Val Val Glu Asp Ile Ser Thr Gly Phe Arg 
                565                 570                 575     


Leu Tyr Lys Pro Arg Leu Ala Ser Thr His Val Tyr Gln Ile Met Asn 
            580                 585                 590         


His Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro Ala Phe Ser Arg Leu 
        595                 600                 605             


Leu Arg Gln Leu Ala Glu Ile Ala Glu Ser Gly Leu 
    610                 615                 620 


<210>  5639
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITLN1__Homo_sapiens__NP_060095

<400>  5639

Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr Arg Gly 
1               5                   10                  15      


Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr Cys Ser 
            20                  25                  30          


Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp Glu Cys 
        35                  40                  45              


Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn Gly Val 
    50                  55                  60                  


Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val 
                85                  90                  95      


Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu 
            100                 105                 110         


Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala 
        115                 120                 125             


Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala 
    130                 135                 140                 


Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His 
145                 150                 155                 160 


Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly Phe Leu 
                165                 170                 175     


Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val 
            180                 185                 190         


Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val Ile Pro 
        195                 200                 205             


Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr Tyr Ser 
    210                 215                 220                 


Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe Arg Val 
225                 230                 235                 240 


Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met Arg Val 
                245                 250                 255     


Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly Tyr Phe 
            260                 265                 270         


Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe Asp Trp 
        275                 280                 285             


Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr 
    290                 295                 300                 


Glu Ala Ala Val Leu Leu Phe Tyr Arg 
305                 310             


<210>  5640
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITLN2__Homo_sapiens__XP_011507512

<400>  5640

Met Leu Ser Met Leu Arg Thr Met Thr Arg Leu Cys Phe Leu Leu Phe 
1               5                   10                  15      


Phe Ser Val Ala Thr Ser Gly Cys Ser Ala Ala Ala Ala Ser Ser Leu 
            20                  25                  30          


Glu Met Leu Ser Arg Glu Phe Glu Thr Cys Ala Phe Ser Phe Ser Ser 
        35                  40                  45              


Leu Pro Arg Ser Cys Lys Glu Ile Lys Glu Arg Cys His Ser Ala Gly 
    50                  55                  60                  


Asp Gly Leu Tyr Phe Leu Arg Thr Lys Asn Gly Val Val Tyr Gln Thr 
65                  70                  75                  80  


Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr Leu Val Ala Ser 
                85                  90                  95      


Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val Gly Asp Arg Trp 
            100                 105                 110         


Ser Ser Gln Gln Gly Asn Lys Ala Asp Tyr Pro Glu Gly Asp Gly Asn 
        115                 120                 125             


Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala Ala Thr Ser Asp 
    130                 135                 140                 


Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala Lys Asp Leu Gly 
145                 150                 155                 160 


Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His Trp Arg Asn Ser 
                165                 170                 175     


Ala Leu Leu Arg Tyr Arg Thr Asn Thr Gly Phe Leu Gln Arg Leu Gly 
            180                 185                 190         


His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val Lys Tyr Arg Ser 
        195                 200                 205             


Gly Lys Cys Trp Asn Asp Asn Gly Pro Ala Ile Pro Val Val Tyr Asp 
    210                 215                 220                 


Phe Gly Asp Ala Lys Lys Thr Ala Ser Tyr Tyr Ser Pro Tyr Gly Gln 
225                 230                 235                 240 


Arg Glu Phe Val Ala Gly Phe Val Gln Phe Arg Val Phe Asn Asn Glu 
                245                 250                 255     


Arg Ala Ala Asn Ala Leu Cys Ala Gly Ile Lys Val Thr Gly Cys Asn 
            260                 265                 270         


Thr Glu His His Cys Ile Gly Gly Gly Gly Phe Phe Pro Gln Gly Lys 
        275                 280                 285             


Pro Arg Gln Cys Gly Asp Phe Ser Ala Phe Asp Trp Asp Gly Tyr Gly 
    290                 295                 300                 


Thr His Val Lys Ser Ser Cys Ser Arg Glu Ile Thr Glu Ala Ala Val 
305                 310                 315                 320 


Leu Leu Phe Tyr Arg 
                325 


<210>  5641
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITM2A__Homo_sapiens__NP_001165052

<400>  5641

Met Val Lys Ile Ala Phe Asn Thr Pro Thr Ala Val Gln Lys Glu Glu 
1               5                   10                  15      


Ala Arg Gln Asp Val Glu Ala Leu Leu Ser Arg Thr Val Arg Thr Gln 
            20                  25                  30          


Ile Leu Thr Gly Lys Ser Thr Ile Tyr Arg Gly Glu Met Cys Phe Phe 
        35                  40                  45              


Asp Ser Glu Asp Pro Ala Asn Ser Leu Arg Gly Gly Glu Pro Asn Phe 
    50                  55                  60                  


Leu Pro Val Thr Glu Glu Ala Asp Ile Arg Glu Asp Asp Asn Ile Ala 
65                  70                  75                  80  


Ile Ile Asp Val Pro Val Pro Ser Phe Ser Asp Ser Asp Pro Ala Ala 
                85                  90                  95      


Ile Ile His Asp Phe Glu Lys Gly Met Thr Ala Tyr Leu Asp Leu Leu 
            100                 105                 110         


Leu Gly Asn Cys Tyr Leu Met Pro Leu Asn Thr Ser Ile Val Met Pro 
        115                 120                 125             


Pro Lys Asn Leu Val Glu Leu Phe Gly Lys Leu Ala Ser Gly Arg Tyr 
    130                 135                 140                 


Leu Pro Gln Thr Tyr Val Val Arg Glu Asp Leu Val Ala Val Glu Glu 
145                 150                 155                 160 


Ile Arg Asp Val Ser Asn Leu Gly Ile Phe Ile Tyr Gln Leu Cys Asn 
                165                 170                 175     


Asn Arg Lys Ser Phe Arg Leu Arg Arg Arg Asp Leu Leu Leu Gly Phe 
            180                 185                 190         


Asn Lys Arg Ala Ile Asp Lys Cys Trp Lys Ile Arg His Phe Pro Asn 
        195                 200                 205             


Glu Phe Ile Val Glu Thr Lys Ile Cys Gln Glu 
    210                 215                 


<210>  5642
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITM2B__Homo_sapiens__NP_068839

<400>  5642

Met Val Lys Val Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu Ala Lys 
1               5                   10                  15      


Lys Asp Glu Pro Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro Pro Asp 
            20                  25                  30          


Ala Val Ala Val Asp Cys Lys Asp Pro Asp Asp Val Val Pro Val Gly 
        35                  40                  45              


Gln Arg Arg Ala Trp Cys Trp Cys Met Cys Phe Gly Leu Ala Phe Met 
    50                  55                  60                  


Leu Ala Gly Val Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr Phe Ala 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Val Tyr Tyr Cys Gly Ile Lys Tyr Ile Lys Asp 
                85                  90                  95      


Asp Val Ile Leu Asn Glu Pro Ser Ala Asp Ala Pro Ala Ala Leu Tyr 
            100                 105                 110         


Gln Thr Ile Glu Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu Val Glu 
        115                 120                 125             


Phe Ile Ser Val Pro Val Pro Glu Phe Ala Asp Ser Asp Pro Ala Asn 
    130                 135                 140                 


Ile Val His Asp Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp Leu Asn 
145                 150                 155                 160 


Leu Asp Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro 
                165                 170                 175     


Pro Arg Asn Leu Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly Thr Tyr 
            180                 185                 190         


Leu Pro Gln Ser Tyr Leu Ile His Glu His Met Val Ile Thr Asp Arg 
        195                 200                 205             


Ile Glu Asn Ile Asp His Leu Gly Phe Phe Ile Tyr Arg Leu Cys His 
    210                 215                 220                 


Asp Lys Glu Thr Tyr Lys Leu Gln Arg Arg Glu Thr Ile Lys Gly Ile 
225                 230                 235                 240 


Gln Lys Arg Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn 
                245                 250                 255     


Lys Phe Ala Val Glu Thr Leu Ile Cys Ser 
            260                 265     


<210>  5643
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITM2C__Homo_sapiens__NP_001012532

<400>  5643

Met Val Lys Ile Ser Phe Gln Pro Ala Val Ala Gly Ile Lys Gly Asp 
1               5                   10                  15      


Lys Ala Asp Lys Ala Ser Ala Ser Ala Pro Ala Pro Ala Ser Ala Thr 
            20                  25                  30          


Glu Ile Leu Leu Thr Pro Ala Arg Leu Ala Arg Asp Asn Phe Phe Arg 
        35                  40                  45              


Cys Gly Val Leu Tyr Glu Asp Ser Leu Ser Ser Gln Val Arg Thr Gln 
    50                  55                  60                  


Met Glu Leu Glu Glu Asp Val Lys Ile Tyr Leu Asp Glu Asn Tyr Glu 
65                  70                  75                  80  


Arg Ile Asn Val Pro Val Pro Gln Phe Gly Gly Gly Asp Pro Ala Asp 
                85                  90                  95      


Ile Ile His Asp Phe Gln Arg Gly Leu Thr Ala Tyr His Asp Ile Ser 
            100                 105                 110         


Leu Asp Lys Cys Tyr Val Ile Glu Leu Asn Thr Thr Ile Val Leu Pro 
        115                 120                 125             


Pro Arg Asn Phe Trp Glu Leu Leu Met Asn Val Lys Arg Gly Thr Tyr 
    130                 135                 140                 


Leu Pro Gln Thr Tyr Ile Ile Gln Glu Glu Met Val Val Thr Glu His 
145                 150                 155                 160 


Val Ser Asp Lys Glu Ala Leu Gly Ser Phe Ile Tyr His Leu Cys Asn 
                165                 170                 175     


Gly Lys Asp Thr Tyr Arg Leu Arg Arg Arg Ala Thr Arg Arg Arg Ile 
            180                 185                 190         


Asn Lys Arg Gly Ala Lys Asn Cys Asn Ala Ile Arg His Phe Glu Asn 
        195                 200                 205             


Thr Phe Val Val Glu Thr Leu Ile Cys Gly Val Val 
    210                 215                 220 


<210>  5644
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITPA__Homo_sapiens__NP_001254552

<400>  5644

Met Ala Ala Ser Leu Val Gly Lys Lys Ile Val Phe Val Thr Gly Asn 
1               5                   10                  15      


Ala Lys Lys Leu Glu Glu Val Gln Gly Pro Val Leu Val Glu Asp Thr 
            20                  25                  30          


Cys Leu Cys Phe Asn Ala Leu Gly Gly Leu Pro Gly Pro Tyr Ile Lys 
        35                  40                  45              


Trp Phe Leu Glu Lys Leu Lys Pro Glu Gly Leu His Gln Leu Leu Ala 
    50                  55                  60                  


Gly Phe Glu Asp Lys Ser Ala Tyr Ala Leu Cys Thr Phe Ala Leu Ser 
65                  70                  75                  80  


Thr Gly Asp Pro Ser Gln Pro Val Arg Leu Phe Arg Gly Arg Thr Ser 
                85                  90                  95      


Gly Arg Ile Val Ala Pro Arg Gly Cys Gln Asp Phe Gly Trp Asp Pro 
            100                 105                 110         


Cys Phe Gln Pro Asp Gly Tyr Glu Gln Thr Tyr Ala Glu Met Pro Lys 
        115                 120                 125             


Ala Glu Lys Asn Ala Val Ser His Arg Phe Arg Ala Leu Leu Glu Leu 
    130                 135                 140                 


Gln Glu Tyr Phe Gly Ser Leu Ala Ala 
145                 150             


<210>  5645
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITPK1__Homo_sapiens__NP_001136065

<400>  5645

Met Gln Thr Phe Leu Lys Gly Lys Arg Val Gly Tyr Trp Leu Ser Glu 
1               5                   10                  15      


Lys Lys Ile Lys Lys Leu Asn Phe Gln Ala Phe Ala Glu Leu Cys Arg 
            20                  25                  30          


Lys Arg Gly Met Glu Val Val Gln Leu Asn Leu Ser Arg Pro Ile Glu 
        35                  40                  45              


Glu Gln Gly Pro Leu Asp Val Ile Ile His Lys Leu Thr Asp Val Ile 
    50                  55                  60                  


Leu Glu Ala Asp Gln Asn Asp Ser Gln Ser Leu Glu Leu Val His Arg 
65                  70                  75                  80  


Phe Gln Glu Tyr Ile Asp Ala His Pro Glu Thr Ile Val Leu Asp Pro 
                85                  90                  95      


Leu Pro Ala Ile Arg Thr Leu Leu Asp Arg Ser Lys Ser Tyr Glu Leu 
            100                 105                 110         


Ile Arg Lys Ile Glu Ala Tyr Met Glu Asp Asp Arg Ile Cys Ser Pro 
        115                 120                 125             


Pro Phe Met Glu Leu Thr Ser Leu Cys Gly Asp Asp Thr Met Arg Leu 
    130                 135                 140                 


Leu Glu Lys Asn Gly Leu Thr Phe Pro Phe Ile Cys Lys Thr Arg Val 
145                 150                 155                 160 


Ala His Gly Thr Asn Ser His Glu Met Ala Ile Val Phe Asn Gln Glu 
                165                 170                 175     


Gly Leu Asn Ala Ile Gln Pro Pro Cys Val Val Gln Asn Phe Ile Asn 
            180                 185                 190         


His Asn Ala Val Leu Tyr Lys Val Phe Val Val Gly Glu Ser Tyr Thr 
        195                 200                 205             


Val Val Gln Arg Pro Ser Leu Lys Asn Phe Ser Ala Gly Thr Ser Asp 
    210                 215                 220                 


Arg Glu Ser Ile Phe Phe Asn Ser His Asn Val Ser Lys Pro Glu Ser 
225                 230                 235                 240 


Ser Ser Val Leu Thr Glu Leu Asp Lys Ile Glu Gly Val Phe Glu Arg 
                245                 250                 255     


Pro Ser Asp Glu Val Ile Arg Glu Leu Ser Arg Ala Leu Arg Gln Ala 
            260                 265                 270         


Leu Gly Val Ser Leu Phe Gly Ile Asp Ile Ile Ile Asn Asn Gln Thr 
        275                 280                 285             


Gly Gln His Ala Val Ile Asp Ile Asn Ala Phe Pro Gly Tyr Glu Gly 
    290                 295                 300                 


Val Ser Glu Phe Phe Thr Asp Leu Leu Asn His Ile Ala Thr Val Leu 
305                 310                 315                 320 


Gln Gly Gln Ser Thr Ala Met Ala Ala Thr Gly Asp Val Ala Leu Leu 
                325                 330                 335     


Arg His Ser Lys Leu Leu Ala Glu Pro Ala Gly Gly Leu Val Gly Glu 
            340                 345                 350         


Arg Thr Cys Ser Ala Ser Pro Gly Cys Cys Gly Ser Met Met Gly Gln 
        355                 360                 365             


Asp Ala Pro Trp Lys Ala Glu Ala Asp Ala Gly Gly Thr Ala Lys Leu 
    370                 375                 380                 


Pro His Gln Arg Leu Gly Cys Asn Ala Gly Val Ser Pro Ser Phe Gln 
385                 390                 395                 400 


Gln His Cys Val Ala Ser Leu Ala Thr Lys Ala Ser Ser Gln 
                405                 410                 


<210>  5646
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITPKA__Homo_sapiens__NP_002211

<400>  5646

Met Thr Leu Pro Gly Gly Pro Thr Gly Met Ala Arg Pro Gly Gly Ala 
1               5                   10                  15      


Arg Pro Cys Ser Pro Gly Leu Glu Arg Ala Pro Arg Arg Ser Val Gly 
            20                  25                  30          


Glu Leu Arg Leu Leu Phe Glu Ala Arg Cys Ala Ala Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Gly Glu Pro Arg Ala Arg Gly Ala Lys Arg Arg Gly Gly 
    50                  55                  60                  


Gln Val Pro Asn Gly Leu Pro Arg Ala Pro Pro Ala Pro Val Ile Pro 
65                  70                  75                  80  


Gln Leu Thr Val Thr Ala Glu Glu Pro Asp Val Pro Pro Thr Ser Pro 
                85                  90                  95      


Gly Pro Pro Glu Arg Glu Arg Asp Cys Leu Pro Ala Ala Gly Ser Ser 
            100                 105                 110         


His Leu Gln Gln Pro Arg Arg Leu Ser Thr Ser Ser Val Ser Ser Thr 
        115                 120                 125             


Gly Ser Ser Ser Leu Leu Glu Asp Ser Glu Asp Asp Leu Leu Ser Asp 
    130                 135                 140                 


Ser Glu Ser Arg Ser Arg Gly Asn Val Gln Leu Glu Ala Gly Glu Asp 
145                 150                 155                 160 


Val Gly Gln Lys Asn His Trp Gln Lys Ile Arg Thr Met Val Asn Leu 
                165                 170                 175     


Pro Val Ile Ser Pro Phe Lys Lys Arg Tyr Ala Trp Val Gln Leu Ala 
            180                 185                 190         


Gly His Thr Gly Ser Phe Lys Ala Ala Gly Thr Ser Gly Leu Ile Leu 
        195                 200                 205             


Lys Arg Cys Ser Glu Pro Glu Arg Tyr Cys Leu Ala Arg Leu Met Ala 
    210                 215                 220                 


Asp Ala Leu Arg Gly Cys Val Pro Ala Phe His Gly Val Val Glu Arg 
225                 230                 235                 240 


Asp Gly Glu Ser Tyr Leu Gln Leu Gln Asp Leu Leu Asp Gly Phe Asp 
                245                 250                 255     


Gly Pro Cys Val Leu Asp Cys Lys Met Gly Val Arg Thr Tyr Leu Glu 
            260                 265                 270         


Glu Glu Leu Thr Lys Ala Arg Glu Arg Pro Lys Leu Arg Lys Asp Met 
        275                 280                 285             


Tyr Lys Lys Met Leu Ala Val Asp Pro Glu Ala Pro Thr Glu Glu Glu 
    290                 295                 300                 


His Ala Gln Arg Ala Val Thr Lys Pro Arg Tyr Met Gln Trp Arg Glu 
305                 310                 315                 320 


Gly Ile Ser Ser Ser Thr Thr Leu Gly Phe Arg Ile Glu Gly Ile Lys 
                325                 330                 335     


Lys Ala Asp Gly Ser Cys Ser Thr Asp Phe Lys Thr Thr Arg Ser Arg 
            340                 345                 350         


Glu Gln Val Leu Arg Val Phe Glu Glu Phe Val Gln Gly Asp Glu Glu 
        355                 360                 365             


Val Leu Arg Arg Tyr Leu Asn Arg Leu Gln Gln Ile Arg Asp Thr Leu 
    370                 375                 380                 


Glu Val Ser Glu Phe Phe Arg Arg His Glu Val Ile Gly Ser Ser Leu 
385                 390                 395                 400 


Leu Phe Val His Asp His Cys His Arg Ala Gly Val Trp Leu Ile Asp 
                405                 410                 415     


Phe Gly Lys Thr Thr Pro Leu Pro Asp Gly Gln Ile Leu Asp His Arg 
            420                 425                 430         


Arg Pro Trp Glu Glu Gly Asn Arg Glu Asp Gly Tyr Leu Leu Gly Leu 
        435                 440                 445             


Asp Asn Leu Ile Gly Ile Leu Ala Ser Leu Ala Glu Arg 
    450                 455                 460     


<210>  5647
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITPKC__Homo_sapiens__XP_006723467

<400>  5647

Met Arg Arg Cys Pro Cys Arg Gly Ser Leu Asn Glu Ala Glu Ala Gly 
1               5                   10                  15      


Ala Leu Pro Ala Ala Ala Arg Met Gly Leu Glu Ala Pro Arg Gly Gly 
            20                  25                  30          


Arg Arg Arg Gln Pro Gly Gln Gln Arg Pro Gly Pro Gly Ala Gly Ala 
        35                  40                  45              


Pro Ala Gly Arg Pro Glu Gly Gly Gly Pro Trp Ala Arg Thr Glu Gly 
    50                  55                  60                  


Ser Ser Leu His Ser Glu Pro Glu Arg Ala Gly Leu Gly Pro Ala Pro 
65                  70                  75                  80  


Gly Thr Glu Ser Pro Gln Ala Glu Phe Trp Thr Asp Gly Gln Thr Glu 
                85                  90                  95      


Pro Ala Ala Ala Gly Leu Gly Val Glu Thr Glu Arg Pro Lys Gln Lys 
            100                 105                 110         


Thr Glu Pro Asp Arg Ser Ser Leu Arg Thr His Leu Glu Trp Ser Trp 
        115                 120                 125             


Ser Glu Leu Glu Thr Thr Cys Leu Trp Thr Glu Thr Gly Thr Asp Gly 
    130                 135                 140                 


Leu Trp Thr Asp Pro His Arg Ser Asp Leu Gln Phe Gln Pro Glu Glu 
145                 150                 155                 160 


Ala Ser Pro Trp Thr Gln Pro Gly Val His Gly Pro Trp Thr Glu Leu 
                165                 170                 175     


Glu Thr His Gly Ser Gln Thr Gln Pro Glu Arg Val Lys Ser Trp Ala 
            180                 185                 190         


Asp Asn Leu Trp Thr His Gln Asn Ser Ser Ser Leu Gln Thr His Pro 
        195                 200                 205             


Glu Gly Ala Cys Pro Ser Lys Glu Pro Ser Ala Asp Gly Ser Trp Lys 
    210                 215                 220                 


Glu Leu Tyr Thr Asp Gly Ser Arg Thr Gln Gln Asp Ile Glu Gly Pro 
225                 230                 235                 240 


Trp Thr Glu Pro Tyr Thr Asp Gly Ser Gln Lys Lys Gln Asp Thr Glu 
                245                 250                 255     


Ala Ala Arg Lys Gln Pro Gly Thr Gly Gly Phe Gln Ile Gln Gln Asp 
            260                 265                 270         


Thr Asp Gly Ser Trp Thr Gln Pro Ser Thr Asp Gly Ser Gln Thr Ala 
        275                 280                 285             


Pro Gly Thr Asp Cys Leu Leu Gly Glu Pro Glu Asp Gly Pro Leu Glu 
    290                 295                 300                 


Glu Pro Glu Pro Gly Glu Leu Leu Thr His Leu Tyr Ser His Leu Lys 
305                 310                 315                 320 


Cys Ser Pro Leu Cys Pro Val Pro Arg Leu Ile Ile Thr Pro Glu Thr 
                325                 330                 335     


Pro Glu Pro Glu Ala Gln Pro Val Gly Pro Pro Ser Arg Val Glu Gly 
            340                 345                 350         


Gly Ser Gly Gly Phe Ser Ser Ala Ser Ser Phe Asp Glu Ser Glu Asp 
        355                 360                 365             


Asp Val Val Ala Gly Gly Gly Gly Ala Ser Asp Pro Glu Asp Arg Ser 
    370                 375                 380                 


Gly Ser Lys Pro Trp Lys Lys Leu Lys Thr Val Leu Lys Tyr Ser Pro 
385                 390                 395                 400 


Phe Val Val Ser Phe Arg Lys His Tyr Pro Trp Val Gln Leu Ser Gly 
                405                 410                 415     


His Ala Gly Asn Phe Gln Ala Gly Glu Asp Gly Arg Ile Leu Lys Arg 
            420                 425                 430         


Phe Cys Gln Cys Glu Gln Arg Ser Leu Glu Gln Leu Met Lys Asp Pro 
        435                 440                 445             


Leu Arg Pro Phe Val Pro Ala Tyr Tyr Gly Met Val Leu Gln Asp Gly 
    450                 455                 460                 


Gln Thr Phe Asn Gln Met Glu Asp Leu Leu Ala Asp Phe Glu Gly Pro 
465                 470                 475                 480 


Ser Ile Met Asp Cys Lys Met Gly Ser Arg Thr Tyr Leu Glu Glu Glu 
                485                 490                 495     


Leu Val Lys Ala Arg Glu Arg Pro Arg Pro Arg Lys Asp Met Tyr Glu 
            500                 505                 510         


Lys Met Val Ala Val Asp Pro Gly Ala Pro Thr Pro Glu Glu His Ala 
        515                 520                 525             


Gln Gly Ala Val Thr Lys Pro Arg Tyr Met Gln Trp Arg Glu Thr Met 
    530                 535                 540                 


Ser Ser Thr Ser Thr Leu Gly Phe Arg Ile Glu Gly Ile Lys Lys Ala 
545                 550                 555                 560 


Asp Gly Thr Cys Asn Thr Asn Phe Lys Lys Thr Gln Ala Leu Glu Gln 
                565                 570                 575     


Val Thr Lys Val Leu Glu Asp Phe Val Asp Gly Asp His Val Ile Leu 
            580                 585                 590         


Gln Lys Tyr Val Ala Cys Leu Glu Glu Leu Arg Glu Ala Leu Glu Ile 
        595                 600                 605             


Ser Pro Phe Phe Lys Thr His Glu Val Val Gly Ser Ser Leu Leu Phe 
    610                 615                 620                 


Val His Asp His Thr Gly Leu Ala Lys Val Trp Met Ile Asp Phe Gly 
625                 630                 635                 640 


Lys Thr Val Ala Leu Pro Asp His Gln Thr Leu Ser His Arg Leu Pro 
                645                 650                 655     


Trp Ala Glu Gly Asn Arg Glu Asp Gly Tyr Leu Trp Gly Leu Asp Asn 
            660                 665                 670         


Met Ile Cys Leu Leu Gln Gly Leu Ala Gln Ser 
        675                 680             


<210>  5648
<211>  2710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITPR1__Homo_sapiens__NP_001093422

<400>  5648

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
        675                 680                 685             


Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
    690                 695                 700                 


Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
705                 710                 715                 720 


Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                725                 730                 735     


Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
            740                 745                 750         


Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
        755                 760                 765             


Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
    770                 775                 780                 


Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
785                 790                 795                 800 


Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                805                 810                 815     


Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
            820                 825                 830         


Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
        835                 840                 845             


Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
    850                 855                 860                 


Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
865                 870                 875                 880 


Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
            900                 905                 910         


Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly Val 
        915                 920                 925             


Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu Pro 
    930                 935                 940                 


Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala Glu 
945                 950                 955                 960 


Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile Ile 
                965                 970                 975     


Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser 
            980                 985                 990         


Cys Leu Leu Cys Ile Phe Lys Arg  Glu Phe Asp Glu Ser  Asn Ser Gln 
        995                 1000                 1005             


Thr Ser  Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
    1010                 1015                 1020             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1025                 1030                 1035             


Glu Gly  Ile Phe Gly Gly Ser  Glu Glu Asn Thr Pro  Leu Asp Leu 
    1040                 1045                 1050             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1055                 1060                 1065             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1070                 1075                 1080             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1085                 1090                 1095             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1100                 1105                 1110             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1115                 1120                 1125             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1130                 1135                 1140             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1145                 1150                 1155             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1160                 1165                 1170             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1175                 1180                 1185             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1190                 1195                 1200             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1205                 1210                 1215             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1220                 1225                 1230             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1235                 1240                 1245             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1250                 1255                 1260             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1265                 1270                 1275             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1280                 1285                 1290             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1295                 1300                 1305             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1310                 1315                 1320             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1325                 1330                 1335             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1340                 1345                 1350             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1355                 1360                 1365             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1445                 1450                 1455             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1460                 1465                 1470             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1475                 1480                 1485             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1490                 1495                 1500             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1505                 1510                 1515             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1550                 1555                 1560             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1565                 1570                 1575             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1580                 1585                 1590             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1595                 1600                 1605             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1610                 1615                 1620             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1625                 1630                 1635             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1640                 1645                 1650             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1655                 1660                 1665             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1670                 1675                 1680             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1685                 1690                 1695             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1700                 1705                 1710             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1715                 1720                 1725             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1730                 1735                 1740             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1745                 1750                 1755             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1760                 1765                 1770             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1775                 1780                 1785             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1790                 1795                 1800             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1805                 1810                 1815             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1820                 1825                 1830             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1835                 1840                 1845             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1850                 1855                 1860             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1865                 1870                 1875             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1880                 1885                 1890             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1895                 1900                 1905             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1910                 1915                 1920             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1925                 1930                 1935             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1940                 1945                 1950             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1955                 1960                 1965             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1970                 1975                 1980             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1985                 1990                 1995             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    2000                 2005                 2010             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2015                 2020                 2025             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2030                 2035                 2040             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2045                 2050                 2055             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2060                 2065                 2070             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2075                 2080                 2085             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2090                 2095                 2100             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2105                 2110                 2115             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2120                 2125                 2130             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2135                 2140                 2145             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2150                 2155                 2160             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2165                 2170                 2175             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2180                 2185                 2190             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2195                 2200                 2205             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2210                 2215                 2220             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2225                 2230                 2235             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2240                 2245                 2250             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2255                 2260                 2265             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2270                 2275                 2280             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2285                 2290                 2295             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2300                 2305                 2310             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2315                 2320                 2325             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2330                 2335                 2340             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2345                 2350                 2355             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2360                 2365                 2370             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2375                 2380                 2385             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2390                 2395                 2400             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2405                 2410                 2415             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2420                 2425                 2430             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2435                 2440                 2445             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2450                 2455                 2460             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2465                 2470                 2475             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2480                 2485                 2490             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2495                 2500                 2505             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2510                 2515                 2520             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2525                 2530                 2535             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2540                 2545                 2550             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2555                 2560                 2565             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2570                 2575                 2580             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2585                 2590                 2595             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2600                 2605                 2610             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2615                 2620                 2625             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2630                 2635                 2640             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2645                 2650                 2655             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2660                 2665                 2670             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2675                 2680                 2685             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2690                 2695                 2700             


Val Asn  Pro Gln Gln Pro Ala  
    2705                 2710 


<210>  5649
<211>  2701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITPR2__Homo_sapiens__NP_002214

<400>  5649

Met Thr Glu Lys Met Ser Ser Phe Leu Tyr Ile Gly Asp Ile Val Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val His Pro Glu Ala Gly Asp Leu Ala Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Ala Lys Gln 
65                  70                  75                  80  


Gly Asn His Thr Glu Ala Ala Leu Leu Lys Lys Leu Gln His Ala Ala 
                85                  90                  95      


Glu Leu Glu Gln Lys Gln Asn Glu Ser Glu Asn Lys Lys Leu Leu Gly 
            100                 105                 110         


Glu Ile Val Lys Tyr Ser Asn Val Ile Gln Leu Leu His Ile Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Ser Leu Asp Ala Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile His Pro Phe Trp Lys Leu Arg Ser Glu Gly Asp Asn Ile 
                165                 170                 175     


Val Val Gly Asp Lys Val Val Leu Met Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Asn Ile Glu Leu Leu Asp Asn Pro Gly Cys Lys Glu 
        195                 200                 205             


Val Asn Ala Val Asn Cys Asn Thr Ser Trp Lys Ile Thr Leu Phe Met 
    210                 215                 220                 


Lys Tyr Ser Ser Tyr Arg Glu Asp Val Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu Tyr 
                245                 250                 255     


Glu Lys Lys Gln His Ile Phe Leu Arg Thr Thr Leu Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Ile Glu Val Val His 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Gln Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Leu Asn Pro 
305                 310                 315                 320 


Asp Tyr Arg Asp Ala Gln Asn Glu Gly Lys Asn Val Arg Asp Gly Val 
                325                 330                 335     


Pro Pro Thr Ser Lys Lys Lys Arg Gln Ala Gly Glu Lys Ile Met Tyr 
            340                 345                 350         


Thr Leu Val Ser Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu 
        355                 360                 365             


Leu Asp Ala Thr Thr Leu Gln Arg Ala Asp Cys Leu Val Pro Arg Asn 
    370                 375                 380                 


Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val Thr Ser 
385                 390                 395                 400 


Thr Ser Ile Pro Ile Asp Thr Asp Glu Glu Arg Pro Val Met Leu Lys 
                405                 410                 415     


Ile Gly Thr Cys Gln Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val 
            420                 425                 430         


Ser Val Pro Leu Ser Glu Val Arg Asp Leu Asp Phe Ala Asn Asp Ala 
        435                 440                 445             


Asn Lys Val Leu Ala Thr Thr Val Lys Lys Leu Glu Asn Gly Thr Ile 
    450                 455                 460                 


Thr Gln Asn Glu Arg Arg Phe Val Thr Lys Leu Leu Glu Asp Leu Ile 
465                 470                 475                 480 


Phe Phe Val Ala Asp Val Pro Asn Asn Gly Gln Glu Val Leu Asp Val 
                485                 490                 495     


Val Ile Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln 
            500                 505                 510         


Asn Ile Leu Ala Gln Val Phe Gly Ile Leu Lys Ala Pro Phe Lys Glu 
        515                 520                 525             


Lys Ala Gly Glu Gly Ser Met Leu Arg Leu Glu Asp Leu Gly Asp Gln 
    530                 535                 540                 


Arg Tyr Ala Pro Tyr Lys Tyr Met Leu Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Asn Phe Cys Val Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Lys Glu Ile Glu Thr Phe Val Ser Leu Leu Arg Arg 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Asn Thr Thr Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Phe Met 
                645                 650                 655     


Leu Ser Pro Gly Asn Ala Asp Ile Leu Ile Gln Thr Lys Val Val Ser 
            660                 665                 670         


Met Gln Ala Asp Asn Pro Met Glu Ser Ser Ile Leu Ser Asp Asp Ile 
        675                 680                 685             


Asp Asp Glu Glu Val Trp Leu Tyr Trp Ile Asp Ser Asn Lys Glu Pro 
    690                 695                 700                 


His Gly Lys Ala Ile Arg His Leu Ala Gln Glu Ala Lys Glu Gly Thr 
705                 710                 715                 720 


Lys Ala Asp Leu Glu Val Leu Thr Tyr Tyr Arg Tyr Gln Leu Asn Leu 
                725                 730                 735     


Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asn Gln Ile 
            740                 745                 750         


Ser Thr Gln Leu Ser Val Asp Leu Ile Leu Arg Cys Val Ser Asp Glu 
        755                 760                 765             


Ser Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys Arg Leu Met Leu His 
    770                 775                 780                 


Met His Val Asp Arg Asp Pro Gln Glu Ser Val Val Pro Val Arg Tyr 
785                 790                 795                 800 


Ala Arg Leu Trp Thr Glu Ile Pro Thr Lys Ile Thr Ile His Glu Tyr 
                805                 810                 815     


Asp Ser Ile Thr Asp Ser Ser Arg Asn Asp Met Lys Arg Lys Phe Ala 
            820                 825                 830         


Leu Thr Met Glu Phe Val Glu Glu Tyr Leu Lys Glu Val Val Asn Gln 
        835                 840                 845             


Pro Phe Pro Phe Gly Asp Lys Glu Lys Asn Lys Leu Thr Phe Glu Val 
    850                 855                 860                 


Val His Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser 
865                 870                 875                 880 


Glu Leu Leu Arg Leu Thr Arg Thr Leu Leu Ala Ile Leu Asp Ile Val 
                885                 890                 895     


Gln Ala Pro Met Ser Ser Tyr Phe Glu Arg Leu Ser Lys Phe Gln Asp 
            900                 905                 910         


Gly Gly Asn Asn Val Met Arg Thr Ile His Gly Val Gly Glu Met Met 
        915                 920                 925             


Thr Gln Met Val Leu Ser Arg Gly Ser Ile Phe Pro Met Ser Val Pro 
    930                 935                 940                 


Asp Val Pro Pro Ser Ile His Pro Ser Lys Gln Gly Ser Pro Thr Glu 
945                 950                 955                 960 


His Glu Asp Val Thr Val Met Asp Thr Lys Leu Lys Ile Ile Glu Ile 
                965                 970                 975     


Leu Gln Phe Ile Leu Ser Val Arg Leu Asp Tyr Arg Ile Ser Tyr Met 
            980                 985                 990         


Leu Ser Ile Tyr Lys Lys Glu Phe  Gly Glu Asp Asn Asp  Asn Ala Glu 
        995                 1000                 1005             


Thr Ser  Ala Ser Gly Ser Pro  Asp Thr Leu Leu Pro  Ser Ala Ile 
    1010                 1015                 1020             


Val Pro  Asp Ile Asp Glu Ile  Ala Ala Gln Ala Glu  Thr Met Phe 
    1025                 1030                 1035             


Ala Gly  Arg Lys Glu Lys Asn  Pro Val Gln Leu Asp  Asp Glu Gly 
    1040                 1045                 1050             


Gly Arg  Thr Phe Leu Arg Val  Leu Ile His Leu Ile  Met His Asp 
    1055                 1060                 1065             


Tyr Pro  Pro Leu Leu Ser Gly  Ala Leu Gln Leu Leu  Phe Lys His 
    1070                 1075                 1080             


Phe Ser  Gln Arg Ala Glu Val  Leu Gln Ala Phe Lys  Gln Val Gln 
    1085                 1090                 1095             


Leu Leu  Val Ser Asn Gln Asp  Val Asp Asn Tyr Lys  Gln Ile Lys 
    1100                 1105                 1110             


Ala Asp  Leu Asp Gln Leu Arg  Leu Thr Val Glu Lys  Ser Glu Leu 
    1115                 1120                 1125             


Trp Val  Glu Lys Ser Ser Asn  Tyr Glu Asn Gly Glu  Ile Gly Glu 
    1130                 1135                 1140             


Ser Gln  Val Lys Gly Gly Glu  Glu Pro Ile Glu Glu  Ser Asn Ile 
    1145                 1150                 1155             


Leu Ser  Pro Val Gln Asp Gly  Thr Lys Lys Pro Gln  Ile Asp Ser 
    1160                 1165                 1170             


Asn Lys  Ser Asn Asn Tyr Arg  Ile Val Lys Glu Ile  Leu Ile Arg 
    1175                 1180                 1185             


Leu Ser  Lys Leu Cys Val Gln  Asn Lys Lys Cys Arg  Asn Gln His 
    1190                 1195                 1200             


Gln Arg  Leu Leu Lys Asn Met  Gly Ala His Ser Val  Val Leu Asp 
    1205                 1210                 1215             


Leu Leu  Gln Ile Pro Tyr Glu  Lys Asn Asp Glu Lys  Met Asn Glu 
    1220                 1225                 1230             


Val Met  Asn Leu Ala His Thr  Phe Leu Gln Asn Phe  Cys Arg Gly 
    1235                 1240                 1245             


Asn Pro  Gln Asn Gln Val Leu  Leu His Lys His Leu  Asn Leu Phe 
    1250                 1255                 1260             


Leu Thr  Pro Gly Leu Leu Glu  Ala Glu Thr Met Arg  His Ile Phe 
    1265                 1270                 1275             


Met Asn  Asn Tyr His Leu Cys  Asn Glu Ile Ser Glu  Arg Val Val 
    1280                 1285                 1290             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  His Val Glu 
    1295                 1300                 1305             


Tyr Leu  Arg Phe Leu Gln Thr  Ile Val Lys Ala Asp  Gly Lys Tyr 
    1310                 1315                 1320             


Val Lys  Lys Cys Gln Asp Met  Val Met Thr Glu Leu  Ile Asn Gly 
    1325                 1330                 1335             


Gly Glu  Asp Val Leu Ile Phe  Tyr Asn Asp Arg Ala  Ser Phe Pro 
    1340                 1345                 1350             


Ile Leu  Leu His Met Met Cys  Ser Glu Arg Asp Arg  Gly Asp Glu 
    1355                 1360                 1365             


Ser Gly  Pro Leu Ala Tyr His  Ile Thr Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Ala Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Asp 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Val Asn  Phe Val Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Ile Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Met 
    1445                 1450                 1455             


Ala Arg  Val Cys Asn Thr Thr  Thr Asp Arg Lys His  Ala Asp Ile 
    1460                 1465                 1470             


Phe Leu  Glu Lys Cys Val Thr  Glu Ser Ile Met Asn  Ile Val Ser 
    1475                 1480                 1485             


Gly Phe  Phe Asn Ser Pro Phe  Ser Asp Asn Ser Thr  Ser Leu Gln 
    1490                 1495                 1500             


Thr His  Gln Pro Val Phe Ile  Gln Leu Leu Gln Ser  Ala Phe Arg 
    1505                 1510                 1515             


Ile Tyr  Asn Cys Thr Trp Pro  Asn Pro Ala Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Thr Leu  Ala Glu Val Ala Lys  Asn Arg Gly 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Thr Leu Phe 
    1550                 1555                 1560             


Met Lys  Ser His Ser Asn Met  Val Gln Arg Ala Ala  Met Gly Trp 
    1565                 1570                 1575             


Arg Leu  Ser Ala Arg Ser Gly  Pro Arg Phe Lys Glu  Ala Leu Gly 
    1580                 1585                 1590             


Gly Pro  Ala Trp Asp Tyr Arg  Asn Ile Ile Glu Lys  Leu Gln Asp 
    1595                 1600                 1605             


Val Val  Ala Ser Leu Glu His  Gln Phe Ser Pro Met  Met Gln Ala 
    1610                 1615                 1620             


Glu Phe  Ser Val Leu Val Asp  Val Leu Tyr Ser Pro  Glu Leu Leu 
    1625                 1630                 1635             


Phe Pro  Glu Gly Ser Asp Ala  Arg Ile Arg Cys Gly  Ala Phe Met 
    1640                 1645                 1650             


Ser Lys  Leu Ile Asn His Thr  Lys Lys Leu Met Glu  Lys Glu Glu 
    1655                 1660                 1665             


Lys Leu  Cys Ile Lys Ile Leu  Gln Thr Leu Arg Glu  Met Leu Glu 
    1670                 1675                 1680             


Lys Lys  Asp Ser Phe Val Glu  Glu Gly Asn Thr Leu  Arg Lys Ile 
    1685                 1690                 1695             


Leu Leu  Asn Arg Tyr Phe Lys  Gly Asp Tyr Ser Ile  Gly Val Asn 
    1700                 1705                 1710             


Gly His  Leu Ser Gly Ala Tyr  Ser Lys Thr Ala Gln  Val Gly Gly 
    1715                 1720                 1725             


Ser Phe  Ser Gly Gln Asp Ser  Asp Lys Met Gly Ile  Ser Met Ser 
    1730                 1735                 1740             


Asp Ile  Gln Cys Leu Leu Asp  Lys Glu Gly Ala Ser  Glu Leu Val 
    1745                 1750                 1755             


Ile Asp  Val Ile Val Asn Thr  Lys Asn Asp Arg Ile  Phe Ser Glu 
    1760                 1765                 1770             


Gly Ile  Phe Leu Gly Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Gln 
    1775                 1780                 1785             


Thr Gln  Tyr Ser Phe Tyr Gln  Gln Leu His Glu Gln  Lys Lys Ser 
    1790                 1795                 1800             


Glu Lys  Phe Phe Lys Val Leu  Tyr Asp Arg Met Lys  Ala Ala Gln 
    1805                 1810                 1815             


Lys Glu  Ile Arg Ser Thr Val  Thr Val Asn Thr Ile  Asp Leu Gly 
    1820                 1825                 1830             


Asn Lys  Lys Arg Asp Asp Asp  Asn Glu Leu Met Thr  Ser Gly Pro 
    1835                 1840                 1845             


Arg Met  Arg Val Arg Asp Ser  Thr Leu His Leu Lys  Glu Gly Met 
    1850                 1855                 1860             


Lys Gly  Gln Leu Thr Glu Ala  Ser Ser Ala Thr Ser  Lys Ala Tyr 
    1865                 1870                 1875             


Cys Val  Tyr Arg Arg Glu Met  Asp Pro Glu Ile Asp  Ile Met Cys 
    1880                 1885                 1890             


Thr Gly  Pro Glu Ala Gly Asn  Thr Glu Glu Lys Ser  Ala Glu Glu 
    1895                 1900                 1905             


Val Thr  Met Ser Pro Ala Ile  Ala Ile Met Gln Pro  Ile Leu Arg 
    1910                 1915                 1920             


Phe Leu  Gln Leu Leu Cys Glu  Asn His Asn Arg Glu  Leu Gln Asn 
    1925                 1930                 1935             


Phe Leu  Arg Asn Gln Asn Asn  Lys Thr Asn Tyr Asn  Leu Val Cys 
    1940                 1945                 1950             


Glu Thr  Leu Gln Phe Leu Asp  Cys Ile Cys Gly Ser  Thr Thr Gly 
    1955                 1960                 1965             


Gly Leu  Gly Leu Leu Gly Leu  Tyr Ile Asn Glu Lys  Asn Val Ala 
    1970                 1975                 1980             


Leu Val  Asn Gln Asn Leu Glu  Ser Leu Thr Glu Tyr  Cys Gln Gly 
    1985                 1990                 1995             


Pro Cys  His Glu Asn Gln Thr  Cys Ile Ala Thr His  Glu Ser Asn 
    2000                 2005                 2010             


Gly Ile  Asp Ile Ile Ile Ala  Leu Ile Leu Asn Asp  Ile Asn Pro 
    2015                 2020                 2025             


Leu Gly  Lys Tyr Arg Met Asp  Leu Val Leu Gln Leu  Lys Asn Asn 
    2030                 2035                 2040             


Ala Ser  Lys Leu Leu Leu Ala  Ile Met Glu Ser Arg  His Asp Ser 
    2045                 2050                 2055             


Glu Asn  Ala Glu Arg Ile Leu  Phe Asn Met Arg Pro  Arg Glu Leu 
    2060                 2065                 2070             


Val Asp  Val Met Lys Asn Ala  Tyr Asn Gln Gly Leu  Glu Cys Asp 
    2075                 2080                 2085             


His Gly  Asp Asp Glu Gly Gly  Asp Asp Gly Val Ser  Pro Lys Asp 
    2090                 2095                 2100             


Val Gly  His Asn Ile Tyr Ile  Leu Ala His Gln Leu  Ala Arg His 
    2105                 2110                 2115             


Asn Lys  Leu Leu Gln Gln Met  Leu Lys Pro Gly Ser  Asp Pro Asp 
    2120                 2125                 2130             


Glu Gly  Asp Glu Ala Leu Lys  Tyr Tyr Ala Asn His  Thr Ala Gln 
    2135                 2140                 2145             


Ile Glu  Ile Val Arg His Asp  Arg Thr Met Glu Gln  Ile Val Phe 
    2150                 2155                 2160             


Pro Val  Pro Asn Ile Cys Glu  Tyr Leu Thr Arg Glu  Ser Lys Cys 
    2165                 2170                 2175             


Arg Val  Phe Asn Thr Thr Glu  Arg Asp Glu Gln Gly  Ser Lys Val 
    2180                 2185                 2190             


Asn Asp  Phe Phe Gln Gln Thr  Glu Asp Leu Tyr Asn  Glu Met Lys 
    2195                 2200                 2205             


Trp Gln  Lys Lys Ile Arg Asn  Asn Pro Ala Leu Phe  Trp Phe Ser 
    2210                 2215                 2220             


Arg His  Ile Ser Leu Trp Gly  Ser Ile Ser Phe Asn  Leu Ala Val 
    2225                 2230                 2235             


Phe Ile  Asn Leu Ala Val Ala  Leu Phe Tyr Pro Phe  Gly Asp Asp 
    2240                 2245                 2250             


Gly Asp  Glu Gly Thr Leu Ser  Pro Leu Phe Ser Val  Leu Leu Trp 
    2255                 2260                 2265             


Ile Ala  Val Ala Ile Cys Thr  Ser Met Leu Phe Phe  Phe Ser Lys 
    2270                 2275                 2280             


Pro Val  Gly Ile Arg Pro Phe  Leu Val Ser Ile Met  Leu Arg Ser 
    2285                 2290                 2295             


Ile Tyr  Thr Ile Gly Leu Gly  Pro Thr Leu Ile Leu  Leu Gly Ala 
    2300                 2305                 2310             


Ala Asn  Leu Cys Asn Lys Ile  Val Phe Leu Val Ser  Phe Val Gly 
    2315                 2320                 2325             


Asn Arg  Gly Thr Phe Thr Arg  Gly Tyr Arg Ala Val  Ile Leu Asp 
    2330                 2335                 2340             


Met Ala  Phe Leu Tyr His Val  Ala Tyr Val Leu Val  Cys Met Leu 
    2345                 2350                 2355             


Gly Leu  Phe Val His Glu Phe  Phe Tyr Ser Phe Leu  Leu Phe Asp 
    2360                 2365                 2370             


Leu Val  Tyr Arg Glu Glu Thr  Leu Leu Asn Val Ile  Lys Ser Val 
    2375                 2380                 2385             


Thr Arg  Asn Gly Arg Ser Ile  Ile Leu Thr Ala Val  Leu Ala Leu 
    2390                 2395                 2400             


Ile Leu  Val Tyr Leu Phe Ser  Ile Ile Gly Phe Leu  Phe Leu Lys 
    2405                 2410                 2415             


Asp Asp  Phe Thr Met Glu Val  Asp Arg Leu Lys Asn  Arg Thr Pro 
    2420                 2425                 2430             


Val Thr  Gly Ser His Gln Val  Pro Thr Met Thr Leu  Thr Thr Met 
    2435                 2440                 2445             


Met Glu  Ala Cys Ala Lys Glu  Asn Cys Ser Pro Thr  Ile Pro Ala 
    2450                 2455                 2460             


Ser Asn  Thr Ala Asp Glu Glu  Tyr Glu Asp Gly Ile  Glu Arg Thr 
    2465                 2470                 2475             


Cys Asp  Thr Leu Leu Met Cys  Ile Val Thr Val Leu  Asn Gln Gly 
    2480                 2485                 2490             


Leu Arg  Asn Gly Gly Gly Val  Gly Asp Val Leu Arg  Arg Pro Ser 
    2495                 2500                 2505             


Lys Asp  Glu Pro Leu Phe Ala  Ala Arg Val Val Tyr  Asp Leu Leu 
    2510                 2515                 2520             


Phe Tyr  Phe Ile Val Ile Ile  Ile Val Leu Asn Leu  Ile Phe Gly 
    2525                 2530                 2535             


Val Ile  Ile Asp Thr Phe Ala  Asp Leu Arg Ser Glu  Lys Gln Lys 
    2540                 2545                 2550             


Lys Glu  Glu Ile Leu Lys Thr  Thr Cys Phe Ile Cys  Gly Leu Glu 
    2555                 2560                 2565             


Arg Asp  Lys Phe Asp Asn Lys  Thr Val Ser Phe Glu  Glu His Ile 
    2570                 2575                 2580             


Lys Ser  Glu His Asn Met Trp  His Tyr Leu Tyr Phe  Ile Val Leu 
    2585                 2590                 2595             


Val Lys  Val Lys Asp Pro Thr  Glu Tyr Thr Gly Pro  Glu Ser Tyr 
    2600                 2605                 2610             


Val Ala  Gln Met Ile Val Glu  Lys Asn Leu Asp Trp  Phe Pro Arg 
    2615                 2620                 2625             


Met Arg  Ala Met Ser Leu Val  Ser Asn Glu Gly Asp  Ser Glu Gln 
    2630                 2635                 2640             


Asn Glu  Ile Arg Ser Leu Gln  Glu Lys Leu Glu Ser  Thr Met Ser 
    2645                 2650                 2655             


Leu Val  Lys Gln Leu Ser Gly  Gln Leu Ala Glu Leu  Lys Glu Gln 
    2660                 2665                 2670             


Met Thr  Glu Gln Arg Lys Asn  Lys Gln Arg Leu Gly  Phe Leu Gly 
    2675                 2680                 2685             


Ser Asn  Thr Pro His Val Asn  His His Met Pro Pro  His 
    2690                 2695                 2700     


<210>  5650
<211>  2671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITPR3__Homo_sapiens__NP_002215

<400>  5650

Met Ser Glu Met Ser Ser Phe Leu His Ile Gly Asp Ile Val Ser Leu 
1               5                   10                  15      


Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu Val 
            20                  25                  30          


Asp Asp Arg Cys Val Val Glu Pro Ala Ala Gly Asp Leu Asp Asn Pro 
        35                  40                  45              


Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn Arg 
    50                  55                  60                  


Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Thr Lys Gln Asp 
65                  70                  75                  80  


Lys Glu Lys Ile Ala Asp Val Val Leu Leu Gln Lys Leu Gln His Ala 
                85                  90                  95      


Ala Gln Met Glu Gln Lys Gln Asn Asp Thr Glu Asn Lys Lys Val His 
            100                 105                 110         


Gly Asp Val Val Lys Tyr Gly Ser Val Ile Gln Leu Leu His Met Lys 
        115                 120                 125             


Ser Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu 
    130                 135                 140                 


Lys Asn Ala Met Arg Val Thr Leu Asp Ala Thr Gly Asn Glu Gly Ser 
145                 150                 155                 160 


Trp Leu Phe Ile Gln Pro Phe Trp Lys Leu Arg Ser Asn Gly Asp Asn 
                165                 170                 175     


Val Val Val Gly Asp Lys Val Ile Leu Asn Pro Val Asn Ala Gly Gln 
            180                 185                 190         


Pro Leu His Ala Ser Asn Tyr Glu Leu Ser Asp Asn Ala Gly Cys Lys 
        195                 200                 205             


Glu Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Asn Leu Phe 
    210                 215                 220                 


Met Gln Phe Arg Asp His Leu Glu Glu Val Leu Lys Gly Gly Asp Val 
225                 230                 235                 240 


Val Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu 
                245                 250                 255     


Tyr Lys Gly Lys Leu Gln Val Phe Leu Arg Thr Thr Leu Arg Gln Ser 
            260                 265                 270         


Ala Thr Ser Ala Thr Ser Ser Asn Ala Leu Trp Glu Val Glu Val Val 
        275                 280                 285             


His His Asp Pro Cys Arg Gly Gly Ala Gly His Trp Asn Gly Leu Tyr 
    290                 295                 300                 


Arg Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Glu Asn 
305                 310                 315                 320 


Pro Ser Tyr Lys Gly Asp Ala Ser Asp Pro Lys Ala Ala Gly Met Gly 
                325                 330                 335     


Ala Gln Gly Arg Thr Gly Arg Arg Asn Ala Gly Glu Lys Ile Lys Tyr 
            340                 345                 350         


Cys Leu Val Ala Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu 
        355                 360                 365             


Leu Asp Pro Thr Thr Leu Gln Lys Thr Asp Ser Phe Val Pro Arg Asn 
    370                 375                 380                 


Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Ile Gln Ser 
385                 390                 395                 400 


Thr Asn Val Pro Ile Asp Ile Glu Glu Glu Arg Pro Ile Arg Leu Met 
                405                 410                 415     


Leu Gly Thr Cys Pro Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val 
            420                 425                 430         


Ser Val Pro Val Ser Glu Ile Arg Asp Leu Asp Phe Ala Asn Asp Ala 
        435                 440                 445             


Ser Ser Met Leu Ala Ser Ala Val Glu Lys Leu Asn Glu Gly Phe Ile 
    450                 455                 460                 


Ser Gln Asn Asp Arg Arg Phe Val Ile Gln Leu Leu Glu Asp Leu Val 
465                 470                 475                 480 


Phe Phe Val Ser Asp Val Pro Asn Asn Gly Gln Asn Val Leu Asp Ile 
                485                 490                 495     


Met Val Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln 
            500                 505                 510         


Asn Ile Leu Lys Gln Val Phe Gly Ile Leu Lys Ala Pro Phe Arg Glu 
        515                 520                 525             


Lys Gly Gly Glu Gly Pro Leu Val Arg Leu Glu Glu Leu Ser Asp Gln 
    530                 535                 540                 


Lys Asn Ala Pro Tyr Gln His Met Phe Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Glu Asp Tyr Arg Lys Asn Gln Glu His Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Met Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Lys Thr Glu Val Glu Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Asn His Ile Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Cys Val 
                645                 650                 655     


Leu Asp Pro Lys Asn Ser Asp Ile Leu Ile Arg Thr Glu Leu Arg Pro 
            660                 665                 670         


Val Lys Glu Met Ala Gln Ser His Glu Tyr Leu Ser Ile Glu Tyr Ser 
        675                 680                 685             


Glu Glu Glu Val Trp Leu Thr Trp Thr Asp Lys Asn Asn Glu His His 
    690                 695                 700                 


Glu Lys Ser Val Arg Gln Leu Ala Gln Glu Ala Arg Ala Gly Asn Ala 
705                 710                 715                 720 


His Asp Glu Asn Val Leu Ser Tyr Tyr Arg Tyr Gln Leu Lys Leu Phe 
                725                 730                 735     


Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asp Glu Ile Ser 
            740                 745                 750         


Gln Gln Leu Gly Val Asp Leu Ile Phe Leu Cys Met Ala Asp Glu Met 
        755                 760                 765             


Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys His Leu Met Leu His Val 
    770                 775                 780                 


His Val Asp Arg Asp Pro Gln Glu Leu Val Thr Pro Val Lys Phe Ala 
785                 790                 795                 800 


Arg Leu Trp Thr Glu Ile Pro Thr Ala Ile Thr Ile Lys Asp Tyr Asp 
                805                 810                 815     


Ser Asn Leu Asn Ala Ser Arg Asp Asp Lys Lys Asn Lys Phe Ala Asn 
            820                 825                 830         


Thr Met Glu Phe Val Glu Asp Tyr Leu Asn Asn Val Val Ser Glu Ala 
        835                 840                 845             


Val Pro Phe Ala Asn Glu Glu Lys Asn Lys Leu Thr Phe Glu Val Val 
    850                 855                 860                 


Ser Leu Ala His Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser Glu 
865                 870                 875                 880 


Leu Leu Arg Leu Thr Arg Thr Leu Leu Gly Ile Ile Asp Cys Val Gln 
                885                 890                 895     


Gly Pro Pro Ala Met Leu Gln Ala Tyr Glu Asp Pro Gly Gly Lys Asn 
            900                 905                 910         


Val Arg Arg Ser Ile Gln Gly Val Gly His Met Met Ser Thr Met Val 
        915                 920                 925             


Leu Ser Arg Lys Gln Ser Val Phe Ser Ala Pro Ser Leu Ser Ala Gly 
    930                 935                 940                 


Ala Ser Ala Ala Glu Pro Leu Asp Arg Ser Lys Phe Glu Glu Asn Glu 
945                 950                 955                 960 


Asp Ile Val Val Met Glu Thr Lys Leu Lys Ile Leu Glu Ile Leu Gln 
                965                 970                 975     


Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Tyr Leu Leu Ser 
            980                 985                 990         


Val Phe Lys Lys Glu Phe Val Glu  Val Phe Pro Met Gln  Asp Ser Gly 
        995                 1000                 1005             


Ala Asp  Gly Thr Ala Pro Ala  Phe Asp Ser Thr Thr  Ala Asn Met 
    1010                 1015                 1020             


Asn Leu  Asp Arg Ile Gly Glu  Gln Ala Glu Ala Met  Phe Gly Val 
    1025                 1030                 1035             


Gly Lys  Thr Ser Ser Met Leu  Glu Val Asp Asp Glu  Gly Gly Arg 
    1040                 1045                 1050             


Met Phe  Leu Arg Val Leu Ile  His Leu Thr Met His  Asp Tyr Ala 
    1055                 1060                 1065             


Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu Phe Lys  His Phe Ser 
    1070                 1075                 1080             


Gln Arg  Gln Glu Ala Met His  Thr Phe Lys Gln Val  Gln Leu Leu 
    1085                 1090                 1095             


Ile Ser  Ala Gln Asp Val Glu  Asn Tyr Lys Val Ile  Lys Ser Glu 
    1100                 1105                 1110             


Leu Asp  Arg Leu Arg Thr Met  Val Glu Lys Ser Glu  Leu Trp Val 
    1115                 1120                 1125             


Asp Lys  Lys Gly Ser Gly Lys  Gly Glu Glu Val Glu  Ala Gly Ala 
    1130                 1135                 1140             


Ala Lys  Asp Lys Lys Glu Arg  Pro Thr Asp Glu Glu  Gly Phe Leu 
    1145                 1150                 1155             


His Pro  Pro Gly Glu Lys Ser  Ser Glu Asn Tyr Gln  Ile Val Lys 
    1160                 1165                 1170             


Gly Ile  Leu Glu Arg Leu Asn  Lys Met Cys Gly Val  Gly Glu Gln 
    1175                 1180                 1185             


Met Arg  Lys Lys Gln Gln Arg  Leu Leu Lys Asn Met  Asp Ala His 
    1190                 1195                 1200             


Lys Val  Met Leu Asp Leu Leu  Gln Ile Pro Tyr Asp  Lys Gly Asp 
    1205                 1210                 1215             


Ala Lys  Met Met Glu Ile Leu  Arg Tyr Thr His Gln  Phe Leu Gln 
    1220                 1225                 1230             


Lys Phe  Cys Ala Gly Asn Pro  Gly Asn Gln Ala Leu  Leu His Lys 
    1235                 1240                 1245             


His Leu  His Leu Phe Leu Thr  Pro Gly Leu Leu Glu  Ala Glu Thr 
    1250                 1255                 1260             


Met Gln  His Ile Phe Leu Asn  Asn Tyr Gln Leu Cys  Ser Glu Ile 
    1265                 1270                 1275             


Ser Glu  Pro Val Leu Gln His  Phe Val His Leu Leu  Ala Thr His 
    1280                 1285                 1290             


Gly Arg  His Val Gln Tyr Leu  Asp Phe Leu His Thr  Val Ile Lys 
    1295                 1300                 1305             


Ala Glu  Gly Lys Tyr Val Lys  Lys Cys Gln Asp Met  Ile Met Thr 
    1310                 1315                 1320             


Glu Leu  Thr Asn Ala Gly Asp  Asp Val Val Val Phe  Tyr Asn Asp 
    1325                 1330                 1335             


Lys Ala  Ser Leu Ala His Leu  Leu Asp Met Met Lys  Ala Ala Arg 
    1340                 1345                 1350             


Asp Gly  Val Glu Asp His Ser  Pro Leu Met Tyr His  Ile Ser Leu 
    1355                 1360                 1365             


Val Asp  Leu Leu Ala Ala Cys  Ala Glu Gly Lys Asn  Val Tyr Thr 
    1370                 1375                 1380             


Glu Ile  Lys Cys Thr Ser Leu  Leu Pro Leu Glu Asp  Val Val Ser 
    1385                 1390                 1395             


Val Val  Thr His Glu Asp Cys  Ile Thr Glu Val Lys  Met Ala Tyr 
    1400                 1405                 1410             


Val Asn  Phe Val Asn His Cys  Tyr Val Asp Thr Glu  Val Glu Met 
    1415                 1420                 1425             


Lys Glu  Ile Tyr Thr Ser Asn  His Ile Trp Thr Leu  Phe Glu Asn 
    1430                 1435                 1440             


Phe Thr  Leu Asp Met Ala Arg  Val Cys Ser Lys Arg  Glu Lys Arg 
    1445                 1450                 1455             


Val Ala  Asp Pro Thr Leu Glu  Lys Tyr Val Leu Ser  Val Val Leu 
    1460                 1465                 1470             


Asp Thr  Ile Asn Ala Phe Phe  Ser Ser Pro Phe Ser  Glu Asn Ser 
    1475                 1480                 1485             


Thr Ser  Leu Gln Thr His Gln  Thr Ile Val Val Gln  Leu Leu Gln 
    1490                 1495                 1500             


Ser Thr  Thr Arg Leu Leu Glu  Cys Pro Trp Leu Gln  Gln Gln His 
    1505                 1510                 1515             


Lys Gly  Ser Val Glu Ala Cys  Ile Arg Thr Leu Ala  Met Val Ala 
    1520                 1525                 1530             


Lys Gly  Arg Ala Ile Leu Leu  Pro Met Asp Leu Asp  Ala His Ile 
    1535                 1540                 1545             


Ser Ser  Met Leu Ser Ser Gly  Ala Ser Cys Ala Ala  Ala Ala Gln 
    1550                 1555                 1560             


Arg Asn  Ala Ser Ser Tyr Lys  Ala Thr Thr Arg Ala  Phe Pro Arg 
    1565                 1570                 1575             


Val Thr  Pro Thr Ala Asn Gln  Trp Asp Tyr Lys Asn  Ile Ile Glu 
    1580                 1585                 1590             


Lys Leu  Gln Asp Ile Ile Thr  Ala Leu Glu Glu Arg  Leu Lys Pro 
    1595                 1600                 1605             


Leu Val  Gln Ala Glu Leu Ser  Val Leu Val Asp Val  Leu His Trp 
    1610                 1615                 1620             


Pro Glu  Leu Leu Phe Leu Glu  Gly Ser Glu Ala Tyr  Gln Arg Cys 
    1625                 1630                 1635             


Glu Ser  Gly Gly Phe Leu Ser  Lys Leu Ile Gln His  Thr Lys Asp 
    1640                 1645                 1650             


Leu Met  Glu Ser Glu Glu Lys  Leu Cys Ile Lys Val  Leu Arg Thr 
    1655                 1660                 1665             


Leu Gln  Gln Met Leu Leu Lys  Lys Thr Lys Tyr Gly  Asp Arg Gly 
    1670                 1675                 1680             


Asn Gln  Leu Arg Lys Met Leu  Leu Gln Asn Tyr Leu  Gln Asn Arg 
    1685                 1690                 1695             


Lys Ser  Thr Ser Arg Gly Asp  Leu Pro Asp Pro Ile  Gly Thr Gly 
    1700                 1705                 1710             


Leu Asp  Pro Asp Trp Ser Ala  Ile Ala Ala Thr Gln  Cys Arg Leu 
    1715                 1720                 1725             


Asp Lys  Glu Gly Ala Thr Lys  Leu Val Cys Asp Leu  Ile Thr Ser 
    1730                 1735                 1740             


Thr Lys  Asn Glu Lys Ile Phe  Gln Glu Ser Ile Gly  Leu Ala Ile 
    1745                 1750                 1755             


His Leu  Leu Asp Gly Gly Asn  Thr Glu Ile Gln Lys  Ser Phe His 
    1760                 1765                 1770             


Asn Leu  Met Met Ser Asp Lys  Lys Ser Glu Arg Phe  Phe Lys Val 
    1775                 1780                 1785             


Leu His  Asp Arg Met Lys Arg  Ala Gln Gln Glu Thr  Lys Ser Thr 
    1790                 1795                 1800             


Val Ala  Val Asn Met Asn Asp  Leu Gly Ser Gln Pro  His Glu Asp 
    1805                 1810                 1815             


Arg Glu  Pro Val Asp Pro Thr  Thr Lys Gly Arg Val  Ala Ser Phe 
    1820                 1825                 1830             


Ser Ile  Pro Gly Ser Ser Ser  Arg Tyr Ser Leu Gly  Pro Ser Leu 
    1835                 1840                 1845             


Arg Arg  Gly His Glu Val Ser  Glu Arg Val Gln Ser  Ser Glu Met 
    1850                 1855                 1860             


Gly Thr  Ser Val Leu Ile Met  Gln Pro Ile Leu Arg  Phe Leu Gln 
    1865                 1870                 1875             


Leu Leu  Cys Glu Asn His Asn  Arg Asp Leu Gln Asn  Phe Leu Arg 
    1880                 1885                 1890             


Cys Gln  Asn Asn Lys Thr Asn  Tyr Asn Leu Val Cys  Glu Thr Leu 
    1895                 1900                 1905             


Gln Phe  Leu Asp Ile Met Cys  Gly Ser Thr Thr Gly  Gly Leu Gly 
    1910                 1915                 1920             


Leu Leu  Gly Leu Tyr Ile Asn  Glu Asp Asn Val Gly  Leu Val Ile 
    1925                 1930                 1935             


Gln Thr  Leu Glu Thr Leu Thr  Glu Tyr Cys Gln Gly  Pro Cys His 
    1940                 1945                 1950             


Glu Asn  Gln Thr Cys Ile Val  Thr His Glu Ser Asn  Gly Ile Asp 
    1955                 1960                 1965             


Ile Ile  Thr Ala Leu Ile Leu  Asn Asp Ile Ser Pro  Leu Cys Lys 
    1970                 1975                 1980             


Tyr Arg  Met Asp Leu Val Leu  Gln Leu Lys Asp Asn  Ala Ser Lys 
    1985                 1990                 1995             


Leu Leu  Leu Ala Leu Met Glu  Ser Arg His Asp Ser  Glu Asn Ala 
    2000                 2005                 2010             


Glu Arg  Ile Leu Ile Ser Leu  Arg Pro Gln Glu Leu  Val Asp Val 
    2015                 2020                 2025             


Ile Lys  Lys Ala Tyr Leu Gln  Glu Glu Glu Arg Glu  Asn Ser Glu 
    2030                 2035                 2040             


Val Ser  Pro Arg Glu Val Gly  His Asn Ile Tyr Ile  Leu Ala Leu 
    2045                 2050                 2055             


Gln Leu  Ser Arg His Asn Lys  Gln Leu Gln His Leu  Leu Lys Pro 
    2060                 2065                 2070             


Val Lys  Arg Ile Gln Glu Glu  Glu Ala Glu Gly Ile  Ser Ser Met 
    2075                 2080                 2085             


Leu Ser  Leu Asn Asn Lys Gln  Leu Ser Gln Met Leu  Lys Ser Ser 
    2090                 2095                 2100             


Ala Pro  Ala Gln Glu Glu Glu  Glu Asp Pro Leu Ala  Tyr Tyr Glu 
    2105                 2110                 2115             


Asn His  Thr Ser Gln Ile Glu  Ile Val Arg Gln Asp  Arg Ser Met 
    2120                 2125                 2130             


Glu Gln  Ile Val Phe Pro Val  Pro Gly Ile Cys Gln  Phe Leu Thr 
    2135                 2140                 2145             


Glu Glu  Thr Lys His Arg Leu  Phe Thr Thr Thr Glu  Gln Asp Glu 
    2150                 2155                 2160             


Gln Gly  Ser Lys Val Ser Asp  Phe Phe Asp Gln Ser  Ser Phe Leu 
    2165                 2170                 2175             


His Asn  Glu Met Glu Trp Gln  Arg Lys Leu Arg Ser  Met Pro Leu 
    2180                 2185                 2190             


Ile Tyr  Trp Phe Ser Arg Arg  Met Thr Leu Trp Gly  Ser Ile Ser 
    2195                 2200                 2205             


Phe Asn  Leu Ala Val Phe Ile  Asn Ile Ile Ile Ala  Phe Phe Tyr 
    2210                 2215                 2220             


Pro Tyr  Met Glu Gly Ala Ser  Thr Gly Val Leu Asp  Ser Pro Leu 
    2225                 2230                 2235             


Ile Ser  Leu Leu Phe Trp Ile  Leu Ile Cys Phe Ser  Ile Ala Ala 
    2240                 2245                 2250             


Leu Phe  Thr Lys Arg Tyr Ser  Ile Arg Pro Leu Ile  Val Ala Leu 
    2255                 2260                 2265             


Ile Leu  Arg Ser Ile Tyr Tyr  Leu Gly Ile Gly Pro  Thr Leu Asn 
    2270                 2275                 2280             


Ile Leu  Gly Ala Leu Asn Leu  Thr Asn Lys Ile Val  Phe Val Val 
    2285                 2290                 2295             


Ser Phe  Val Gly Asn Arg Gly  Thr Phe Ile Arg Gly  Tyr Lys Ala 
    2300                 2305                 2310             


Met Val  Met Asp Met Glu Phe  Leu Tyr His Val Gly  Tyr Ile Leu 
    2315                 2320                 2325             


Thr Ser  Val Leu Gly Leu Phe  Ala His Glu Leu Phe  Tyr Ser Ile 
    2330                 2335                 2340             


Leu Leu  Phe Asp Leu Ile Tyr  Arg Glu Glu Thr Leu  Phe Asn Val 
    2345                 2350                 2355             


Ile Lys  Ser Val Thr Arg Asn  Gly Arg Ser Ile Leu  Leu Thr Ala 
    2360                 2365                 2370             


Leu Leu  Ala Leu Ile Leu Val  Tyr Leu Phe Ser Ile  Val Gly Phe 
    2375                 2380                 2385             


Leu Phe  Leu Lys Asp Asp Phe  Ile Leu Glu Val Asp  Arg Leu Pro 
    2390                 2395                 2400             


Asn Asn  His Ser Thr Ala Ser  Pro Leu Gly Met Pro  His Gly Ala 
    2405                 2410                 2415             


Ala Ala  Phe Val Asp Thr Cys  Ser Gly Asp Lys Met  Asp Cys Val 
    2420                 2425                 2430             


Ser Gly  Leu Ser Val Pro Glu  Val Leu Glu Glu Asp  Arg Glu Leu 
    2435                 2440                 2445             


Asp Ser  Thr Glu Arg Ala Cys  Asp Thr Leu Leu Met  Cys Ile Val 
    2450                 2455                 2460             


Thr Val  Met Asn His Gly Leu  Arg Asn Gly Gly Gly  Val Gly Asp 
    2465                 2470                 2475             


Ile Leu  Arg Lys Pro Ser Lys  Asp Glu Ser Leu Phe  Pro Ala Arg 
    2480                 2485                 2490             


Val Val  Tyr Asp Leu Leu Phe  Phe Phe Ile Val Ile  Ile Ile Val 
    2495                 2500                 2505             


Leu Asn  Leu Ile Phe Gly Val  Ile Ile Asp Thr Phe  Ala Asp Leu 
    2510                 2515                 2520             


Arg Ser  Glu Lys Gln Lys Lys  Glu Glu Ile Leu Lys  Thr Thr Cys 
    2525                 2530                 2535             


Phe Ile  Cys Gly Leu Glu Arg  Asp Lys Phe Asp Asn  Lys Thr Val 
    2540                 2545                 2550             


Ser Phe  Glu Glu His Ile Lys  Leu Glu His Asn Met  Trp Asn Tyr 
    2555                 2560                 2565             


Leu Tyr  Phe Ile Val Leu Val  Arg Val Lys Asn Lys  Thr Asp Tyr 
    2570                 2575                 2580             


Thr Gly  Pro Glu Ser Tyr Val  Ala Gln Met Ile Lys  Asn Lys Asn 
    2585                 2590                 2595             


Leu Asp  Trp Phe Pro Arg Met  Arg Ala Met Ser Leu  Val Ser Asn 
    2600                 2605                 2610             


Glu Gly  Glu Gly Glu Gln Asn  Glu Ile Arg Ile Leu  Gln Asp Lys 
    2615                 2620                 2625             


Leu Asn  Ser Thr Met Lys Leu  Val Ser His Leu Thr  Ala Gln Leu 
    2630                 2635                 2640             


Asn Glu  Leu Lys Glu Gln Met  Thr Glu Gln Arg Lys  Arg Arg Gln 
    2645                 2650                 2655             


Arg Leu  Gly Phe Val Asp Val  Gln Asn Cys Ile Ser  Arg 
    2660                 2665                 2670     


<210>  5651
<211>  1220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITSN1__Homo_sapiens__NP_001001132

<400>  5651

Met Ala Gln Phe Pro Thr Pro Phe Gly Gly Ser Leu Asp Ile Trp Ala 
1               5                   10                  15      


Ile Thr Val Glu Glu Arg Ala Lys His Asp Gln Gln Phe His Ser Leu 
            20                  25                  30          


Lys Pro Ile Ser Gly Phe Ile Thr Gly Asp Gln Ala Arg Asn Phe Phe 
        35                  40                  45              


Phe Gln Ser Gly Leu Pro Gln Pro Val Leu Ala Gln Ile Trp Ala Leu 
    50                  55                  60                  


Ala Asp Met Asn Asn Asp Gly Arg Met Asp Gln Val Glu Phe Ser Ile 
65                  70                  75                  80  


Ala Met Lys Leu Ile Lys Leu Lys Leu Gln Gly Tyr Gln Leu Pro Ser 
                85                  90                  95      


Ala Leu Pro Pro Val Met Lys Gln Gln Pro Val Ala Ile Ser Ser Ala 
            100                 105                 110         


Pro Ala Phe Gly Met Gly Gly Ile Ala Ser Met Pro Pro Leu Thr Ala 
        115                 120                 125             


Val Ala Pro Val Pro Met Gly Ser Ile Pro Val Val Gly Met Ser Pro 
    130                 135                 140                 


Thr Leu Val Ser Ser Val Pro Thr Ala Ala Val Pro Pro Leu Ala Asn 
145                 150                 155                 160 


Gly Ala Pro Pro Val Ile Gln Pro Leu Pro Ala Phe Ala His Pro Ala 
                165                 170                 175     


Ala Thr Leu Pro Lys Ser Ser Ser Phe Ser Arg Ser Gly Pro Gly Ser 
            180                 185                 190         


Gln Leu Asn Thr Lys Leu Gln Lys Ala Gln Ser Phe Asp Val Ala Ser 
        195                 200                 205             


Val Pro Pro Val Ala Glu Trp Ala Val Pro Gln Ser Ser Arg Leu Lys 
    210                 215                 220                 


Tyr Arg Gln Leu Phe Asn Ser His Asp Lys Thr Met Ser Gly His Leu 
225                 230                 235                 240 


Thr Gly Pro Gln Ala Arg Thr Ile Leu Met Gln Ser Ser Leu Pro Gln 
                245                 250                 255     


Ala Gln Leu Ala Ser Ile Trp Asn Leu Ser Asp Ile Asp Gln Asp Gly 
            260                 265                 270         


Lys Leu Thr Ala Glu Glu Phe Ile Leu Ala Met His Leu Ile Asp Val 
        275                 280                 285             


Ala Met Ser Gly Gln Pro Leu Pro Pro Val Leu Pro Pro Glu Tyr Ile 
    290                 295                 300                 


Pro Pro Ser Phe Arg Arg Val Arg Ser Gly Ser Gly Ile Ser Val Ile 
305                 310                 315                 320 


Ser Ser Thr Ser Val Asp Gln Arg Leu Pro Glu Glu Pro Val Leu Glu 
                325                 330                 335     


Asp Glu Gln Gln Gln Leu Glu Lys Lys Leu Pro Val Thr Phe Glu Asp 
            340                 345                 350         


Lys Lys Arg Glu Asn Phe Glu Arg Gly Asn Leu Glu Leu Glu Lys Arg 
        355                 360                 365             


Arg Gln Ala Leu Leu Glu Gln Gln Arg Lys Glu Gln Glu Arg Leu Ala 
    370                 375                 380                 


Gln Leu Glu Arg Ala Glu Gln Glu Arg Lys Glu Arg Glu Arg Gln Glu 
385                 390                 395                 400 


Gln Glu Arg Lys Arg Gln Leu Glu Leu Glu Lys Gln Leu Glu Lys Gln 
                405                 410                 415     


Arg Glu Leu Glu Arg Gln Arg Glu Glu Glu Arg Arg Lys Glu Ile Glu 
            420                 425                 430         


Arg Arg Glu Ala Ala Lys Arg Glu Leu Glu Arg Gln Arg Gln Leu Glu 
        435                 440                 445             


Trp Glu Arg Asn Arg Arg Gln Glu Leu Leu Asn Gln Arg Asn Lys Glu 
    450                 455                 460                 


Gln Glu Asp Ile Val Val Leu Lys Ala Lys Lys Lys Thr Leu Glu Phe 
465                 470                 475                 480 


Glu Leu Glu Ala Leu Asn Asp Lys Lys His Gln Leu Glu Gly Lys Leu 
                485                 490                 495     


Gln Asp Ile Arg Cys Arg Leu Thr Thr Gln Arg Gln Glu Ile Glu Ser 
            500                 505                 510         


Thr Asn Lys Ser Arg Glu Leu Arg Ile Ala Glu Ile Thr His Leu Gln 
        515                 520                 525             


Gln Gln Leu Gln Glu Ser Gln Gln Met Leu Gly Arg Leu Ile Pro Glu 
    530                 535                 540                 


Lys Gln Ile Leu Asn Asp Gln Leu Lys Gln Val Gln Gln Asn Ser Leu 
545                 550                 555                 560 


His Arg Asp Ser Leu Val Thr Leu Lys Arg Ala Leu Glu Ala Lys Glu 
                565                 570                 575     


Leu Ala Arg Gln His Leu Arg Asp Gln Leu Asp Glu Val Glu Lys Glu 
            580                 585                 590         


Thr Arg Ser Lys Leu Gln Glu Ile Asp Ile Phe Asn Asn Gln Leu Lys 
        595                 600                 605             


Glu Leu Arg Glu Ile His Asn Lys Gln Gln Leu Gln Lys Gln Lys Ser 
    610                 615                 620                 


Met Glu Ala Glu Arg Leu Lys Gln Lys Glu Gln Glu Arg Lys Ile Ile 
625                 630                 635                 640 


Glu Leu Glu Lys Gln Lys Glu Glu Ala Gln Arg Arg Ala Gln Glu Arg 
                645                 650                 655     


Asp Lys Gln Trp Leu Glu His Val Gln Gln Glu Asp Glu His Gln Arg 
            660                 665                 670         


Pro Arg Lys Leu His Glu Glu Glu Lys Leu Lys Arg Glu Glu Ser Val 
        675                 680                 685             


Lys Lys Lys Asp Gly Glu Glu Lys Gly Lys Gln Glu Ala Gln Asp Lys 
    690                 695                 700                 


Leu Gly Arg Leu Phe His Gln His Gln Glu Pro Ala Lys Pro Ala Val 
705                 710                 715                 720 


Gln Ala Pro Trp Ser Thr Ala Glu Lys Gly Pro Leu Thr Ile Ser Ala 
                725                 730                 735     


Gln Glu Asn Val Lys Val Val Tyr Tyr Arg Ala Leu Tyr Pro Phe Glu 
            740                 745                 750         


Ser Arg Ser His Asp Glu Ile Thr Ile Gln Pro Gly Asp Ile Val Met 
        755                 760                 765             


Val Lys Gly Glu Trp Val Asp Glu Ser Gln Thr Gly Glu Pro Gly Trp 
    770                 775                 780                 


Leu Gly Gly Glu Leu Lys Gly Lys Thr Gly Trp Phe Pro Ala Asn Tyr 
785                 790                 795                 800 


Ala Glu Lys Ile Pro Glu Asn Glu Val Pro Ala Pro Val Lys Pro Val 
                805                 810                 815     


Thr Asp Ser Thr Ser Ala Pro Ala Pro Lys Leu Ala Leu Arg Glu Thr 
            820                 825                 830         


Pro Ala Pro Leu Ala Val Thr Ser Ser Glu Pro Ser Thr Thr Pro Asn 
        835                 840                 845             


Asn Trp Ala Asp Phe Ser Ser Thr Trp Pro Thr Ser Thr Asn Glu Lys 
    850                 855                 860                 


Pro Glu Thr Asp Asn Trp Asp Ala Trp Ala Ala Gln Pro Ser Leu Thr 
865                 870                 875                 880 


Val Pro Ser Ala Gly Gln Leu Arg Gln Arg Ser Ala Phe Thr Pro Ala 
                885                 890                 895     


Thr Ala Thr Gly Ser Ser Pro Ser Pro Val Leu Gly Gln Gly Glu Lys 
            900                 905                 910         


Val Glu Gly Leu Gln Ala Gln Ala Leu Tyr Pro Trp Arg Ala Lys Lys 
        915                 920                 925             


Asp Asn His Leu Asn Phe Asn Lys Asn Asp Val Ile Thr Val Leu Glu 
    930                 935                 940                 


Gln Gln Asp Met Trp Trp Phe Gly Glu Val Gln Gly Gln Lys Gly Trp 
945                 950                 955                 960 


Phe Pro Lys Ser Tyr Val Lys Leu Ile Ser Gly Pro Ile Arg Lys Ser 
                965                 970                 975     


Thr Ser Met Asp Ser Gly Ser Ser Glu Ser Pro Ala Ser Leu Lys Arg 
            980                 985                 990         


Val Ala Ser Pro Ala Ala Lys Pro  Val Val Ser Gly Glu  Glu Phe Ile 
        995                 1000                 1005             


Ala Met  Tyr Thr Tyr Glu Ser  Ser Glu Gln Gly Asp  Leu Thr Phe 
    1010                 1015                 1020             


Gln Gln  Gly Asp Val Ile Leu  Val Thr Lys Lys Asp  Gly Asp Trp 
    1025                 1030                 1035             


Trp Thr  Gly Thr Val Gly Asp  Lys Ala Gly Val Phe  Pro Ser Asn 
    1040                 1045                 1050             


Tyr Val  Arg Leu Lys Asp Ser  Glu Gly Ser Gly Thr  Ala Gly Lys 
    1055                 1060                 1065             


Thr Gly  Ser Leu Gly Lys Lys  Pro Glu Ile Ala Gln  Val Ile Ala 
    1070                 1075                 1080             


Ser Tyr  Thr Ala Thr Gly Pro  Glu Gln Leu Thr Leu  Ala Pro Gly 
    1085                 1090                 1095             


Gln Leu  Ile Leu Ile Arg Lys  Lys Asn Pro Gly Gly  Trp Trp Glu 
    1100                 1105                 1110             


Gly Glu  Leu Gln Ala Arg Gly  Lys Lys Arg Gln Ile  Gly Trp Phe 
    1115                 1120                 1125             


Pro Ala  Asn Tyr Val Lys Leu  Leu Ser Pro Gly Thr  Ser Lys Ile 
    1130                 1135                 1140             


Thr Pro  Thr Glu Pro Pro Lys  Ser Thr Ala Leu Ala  Ala Val Cys 
    1145                 1150                 1155             


Gln Val  Ile Gly Met Tyr Asp  Tyr Thr Ala Gln Asn  Asp Asp Glu 
    1160                 1165                 1170             


Leu Ala  Phe Asn Lys Gly Gln  Ile Ile Asn Val Leu  Asn Lys Glu 
    1175                 1180                 1185             


Asp Pro  Asp Trp Trp Lys Gly  Glu Val Asn Gly Gln  Val Gly Leu 
    1190                 1195                 1200             


Phe Pro  Ser Asn Tyr Val Lys  Leu Thr Thr Asp Met  Asp Pro Ser 
    1205                 1210                 1215             


Gln Gln  
    1220 


<210>  5652
<211>  1697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITSN2__Homo_sapiens__NP_006268

<400>  5652

Met Met Ala Gln Phe Pro Thr Ala Met Asn Gly Gly Pro Asn Met Trp 
1               5                   10                  15      


Ala Ile Thr Ser Glu Glu Arg Thr Lys His Asp Arg Gln Phe Asp Asn 
            20                  25                  30          


Leu Lys Pro Ser Gly Gly Tyr Ile Thr Gly Asp Gln Ala Arg Asn Phe 
        35                  40                  45              


Phe Leu Gln Ser Gly Leu Pro Ala Pro Val Leu Ala Glu Ile Trp Ala 
    50                  55                  60                  


Leu Ser Asp Leu Asn Lys Asp Gly Lys Met Asp Gln Gln Glu Phe Ser 
65                  70                  75                  80  


Ile Ala Met Lys Leu Ile Lys Leu Lys Leu Gln Gly Gln Gln Leu Pro 
                85                  90                  95      


Val Val Leu Pro Pro Ile Met Lys Gln Pro Pro Met Phe Ser Pro Leu 
            100                 105                 110         


Ile Ser Ala Arg Phe Gly Met Gly Ser Met Pro Asn Leu Ser Ile Pro 
        115                 120                 125             


Gln Pro Leu Pro Pro Ala Ala Pro Ile Thr Ser Leu Ser Ser Ala Thr 
    130                 135                 140                 


Ser Gly Thr Asn Leu Pro Pro Leu Met Met Pro Thr Pro Leu Val Pro 
145                 150                 155                 160 


Ser Val Ser Thr Ser Ser Leu Pro Asn Gly Thr Ala Ser Leu Ile Gln 
                165                 170                 175     


Pro Leu Pro Ile Pro Tyr Ser Ser Ser Thr Leu Pro His Gly Ser Ser 
            180                 185                 190         


Tyr Ser Leu Met Met Gly Gly Phe Gly Gly Ala Ser Ile Gln Lys Ala 
        195                 200                 205             


Gln Ser Leu Ile Asp Leu Gly Ser Ser Ser Ser Thr Ser Ser Thr Ala 
    210                 215                 220                 


Ser Leu Ser Gly Asn Ser Pro Lys Thr Gly Thr Ser Glu Trp Ala Val 
225                 230                 235                 240 


Pro Gln Pro Thr Arg Leu Lys Tyr Arg Gln Lys Phe Asn Thr Leu Asp 
                245                 250                 255     


Lys Ser Met Ser Gly Tyr Leu Ser Gly Phe Gln Ala Arg Asn Ala Leu 
            260                 265                 270         


Leu Gln Ser Asn Leu Ser Gln Thr Gln Leu Ala Thr Ile Trp Thr Leu 
        275                 280                 285             


Ala Asp Val Asp Gly Asp Gly Gln Leu Lys Ala Glu Glu Phe Ile Leu 
    290                 295                 300                 


Ala Met His Leu Thr Asp Met Ala Lys Ala Gly Gln Pro Leu Pro Leu 
305                 310                 315                 320 


Thr Leu Pro Pro Glu Leu Val Pro Pro Ser Phe Arg Gly Gly Lys Gln 
                325                 330                 335     


Ile Asp Ser Ile Asn Gly Thr Leu Pro Ser Tyr Gln Lys Met Gln Glu 
            340                 345                 350         


Glu Glu Pro Gln Lys Lys Leu Pro Val Thr Phe Glu Asp Lys Arg Lys 
        355                 360                 365             


Ala Asn Tyr Glu Arg Gly Asn Met Glu Leu Glu Lys Arg Arg Gln Ala 
    370                 375                 380                 


Leu Met Glu Gln Gln Gln Arg Glu Ala Glu Arg Lys Ala Gln Lys Glu 
385                 390                 395                 400 


Lys Glu Glu Trp Glu Arg Lys Gln Arg Glu Leu Gln Glu Gln Glu Trp 
                405                 410                 415     


Lys Lys Gln Leu Glu Leu Glu Lys Arg Leu Glu Lys Gln Arg Glu Leu 
            420                 425                 430         


Glu Arg Gln Arg Glu Glu Glu Arg Arg Lys Asp Ile Glu Arg Arg Glu 
        435                 440                 445             


Ala Ala Lys Gln Glu Leu Glu Arg Gln Arg Arg Leu Glu Trp Glu Arg 
    450                 455                 460                 


Ile Arg Arg Gln Glu Leu Leu Asn Gln Lys Asn Arg Glu Gln Glu Glu 
465                 470                 475                 480 


Ile Val Arg Leu Asn Ser Lys Lys Lys Asn Leu His Leu Glu Leu Glu 
                485                 490                 495     


Ala Leu Asn Gly Lys His Gln Gln Ile Ser Gly Arg Leu Gln Asp Val 
            500                 505                 510         


Arg Leu Lys Lys Gln Thr Gln Lys Thr Glu Leu Glu Val Leu Asp Lys 
        515                 520                 525             


Gln Cys Asp Leu Glu Ile Met Glu Ile Lys Gln Leu Gln Gln Glu Leu 
    530                 535                 540                 


Gln Glu Tyr Gln Asn Lys Leu Ile Tyr Leu Val Pro Glu Lys Gln Leu 
545                 550                 555                 560 


Leu Asn Glu Arg Ile Lys Asn Met Gln Phe Ser Asn Thr Pro Asp Ser 
                565                 570                 575     


Gly Val Ser Leu Leu His Lys Lys Ser Leu Glu Lys Glu Glu Leu Cys 
            580                 585                 590         


Gln Arg Leu Lys Glu Gln Leu Asp Ala Leu Glu Lys Glu Thr Ala Ser 
        595                 600                 605             


Lys Leu Ser Glu Met Asp Ser Phe Asn Asn Gln Leu Lys Cys Gly Asn 
    610                 615                 620                 


Met Asp Asp Ser Val Leu Gln Cys Leu Leu Ser Leu Leu Ser Cys Leu 
625                 630                 635                 640 


Asn Asn Leu Phe Leu Leu Leu Lys Glu Leu Arg Glu Thr Tyr Asn Thr 
                645                 650                 655     


Gln Gln Leu Ala Leu Glu Gln Leu Tyr Lys Ile Lys Arg Asp Lys Leu 
            660                 665                 670         


Lys Glu Ile Glu Arg Lys Arg Leu Glu Leu Met Gln Lys Lys Lys Leu 
        675                 680                 685             


Glu Asp Glu Ala Ala Arg Lys Ala Lys Gln Gly Lys Glu Asn Leu Trp 
    690                 695                 700                 


Lys Glu Asn Leu Arg Lys Glu Glu Glu Glu Lys Gln Lys Arg Leu Gln 
705                 710                 715                 720 


Glu Glu Lys Thr Gln Glu Lys Ile Gln Glu Glu Glu Arg Lys Ala Glu 
                725                 730                 735     


Glu Lys Gln Arg Lys Asp Lys Asp Thr Leu Lys Ala Glu Glu Lys Lys 
            740                 745                 750         


Arg Glu Thr Ala Ser Val Leu Val Asn Tyr Arg Ala Leu Tyr Pro Phe 
        755                 760                 765             


Glu Ala Arg Asn His Asp Glu Met Ser Phe Asn Ser Gly Asp Ile Ile 
    770                 775                 780                 


Gln Val Asp Glu Lys Thr Val Gly Glu Pro Gly Trp Leu Tyr Gly Ser 
785                 790                 795                 800 


Phe Gln Gly Asn Phe Gly Trp Phe Pro Cys Asn Tyr Val Glu Lys Met 
                805                 810                 815     


Pro Ser Ser Glu Asn Glu Lys Ala Val Ser Pro Lys Lys Ala Leu Leu 
            820                 825                 830         


Pro Pro Thr Val Ser Leu Ser Ala Thr Ser Thr Ser Ser Glu Pro Leu 
        835                 840                 845             


Ser Ser Asn Gln Pro Ala Ser Val Thr Asp Tyr Gln Asn Val Ser Phe 
    850                 855                 860                 


Ser Asn Leu Thr Val Asn Thr Ser Trp Gln Lys Lys Ser Ala Phe Thr 
865                 870                 875                 880 


Arg Thr Val Ser Pro Gly Ser Val Ser Pro Ile His Gly Gln Gly Gln 
                885                 890                 895     


Val Val Glu Asn Leu Lys Ala Gln Ala Leu Cys Ser Trp Thr Ala Lys 
            900                 905                 910         


Lys Asp Asn His Leu Asn Phe Ser Lys His Asp Ile Ile Thr Val Leu 
        915                 920                 925             


Glu Gln Gln Glu Asn Trp Trp Phe Gly Glu Val His Gly Gly Arg Gly 
    930                 935                 940                 


Trp Phe Pro Lys Ser Tyr Val Lys Ile Ile Pro Gly Ser Glu Val Lys 
945                 950                 955                 960 


Arg Glu Glu Pro Glu Ala Leu Tyr Ala Ala Val Asn Lys Lys Pro Thr 
                965                 970                 975     


Ser Ala Ala Tyr Ser Val Gly Glu Glu Tyr Ile Ala Leu Tyr Pro Tyr 
            980                 985                 990         


Ser Ser Val Glu Pro Gly Asp Leu  Thr Phe Thr Glu Gly  Glu Glu Ile 
        995                 1000                 1005             


Leu Val  Thr Gln Lys Asp Gly  Glu Trp Trp Thr Gly  Ser Ile Gly 
    1010                 1015                 1020             


Asp Arg  Ser Gly Ile Phe Pro  Ser Asn Tyr Val Lys  Pro Lys Asp 
    1025                 1030                 1035             


Gln Glu  Ser Phe Gly Ser Ala  Ser Lys Ser Gly Ala  Ser Asn Lys 
    1040                 1045                 1050             


Lys Pro  Glu Ile Ala Gln Val  Thr Ser Ala Tyr Val  Ala Ser Gly 
    1055                 1060                 1065             


Ser Glu  Gln Leu Ser Leu Ala  Pro Gly Gln Leu Ile  Leu Ile Leu 
    1070                 1075                 1080             


Lys Lys  Asn Thr Ser Gly Trp  Trp Gln Gly Glu Leu  Gln Ala Arg 
    1085                 1090                 1095             


Gly Lys  Lys Arg Gln Lys Gly  Trp Phe Pro Ala Ser  His Val Lys 
    1100                 1105                 1110             


Leu Leu  Gly Pro Ser Ser Glu  Arg Ala Thr Pro Ala  Phe His Pro 
    1115                 1120                 1125             


Val Cys  Gln Val Ile Ala Met  Tyr Asp Tyr Ala Ala  Asn Asn Glu 
    1130                 1135                 1140             


Asp Glu  Leu Ser Phe Ser Lys  Gly Gln Leu Ile Asn  Val Met Asn 
    1145                 1150                 1155             


Lys Asp  Asp Pro Asp Trp Trp  Gln Gly Glu Ile Asn  Gly Val Thr 
    1160                 1165                 1170             


Gly Leu  Phe Pro Ser Asn Tyr  Val Lys Met Thr Thr  Asp Ser Asp 
    1175                 1180                 1185             


Pro Ser  Gln Gln Trp Cys Ala  Asp Leu Gln Thr Leu  Asp Thr Met 
    1190                 1195                 1200             


Gln Pro  Ile Glu Arg Lys Arg  Gln Gly Tyr Ile His  Glu Leu Ile 
    1205                 1210                 1215             


Gln Thr  Glu Glu Arg Tyr Met  Ala Asp Leu Gln Leu  Val Val Glu 
    1220                 1225                 1230             


Val Phe  Gln Lys Arg Met Ala  Glu Ser Gly Phe Leu  Thr Glu Gly 
    1235                 1240                 1245             


Glu Met  Ala Leu Ile Phe Val  Asn Trp Lys Glu Leu  Ile Met Ser 
    1250                 1255                 1260             


Asn Thr  Lys Leu Leu Lys Ala  Leu Arg Val Arg Lys  Lys Thr Gly 
    1265                 1270                 1275             


Gly Glu  Lys Met Pro Val Gln  Met Ile Gly Asp Ile  Leu Ala Ala 
    1280                 1285                 1290             


Glu Leu  Ser His Met Gln Ala  Tyr Ile Arg Phe Cys  Ser Cys Gln 
    1295                 1300                 1305             


Leu Asn  Gly Ala Ala Leu Leu  Gln Gln Lys Thr Asp  Glu Asp Thr 
    1310                 1315                 1320             


Asp Phe  Lys Glu Phe Leu Lys  Lys Leu Ala Ser Asp  Pro Arg Cys 
    1325                 1330                 1335             


Lys Gly  Met Pro Leu Ser Ser  Phe Leu Leu Lys Pro  Met Gln Arg 
    1340                 1345                 1350             


Ile Thr  Arg Tyr Pro Leu Leu  Ile Arg Ser Ile Leu  Glu Asn Thr 
    1355                 1360                 1365             


Pro Glu  Ser His Ala Asp His  Ser Ser Leu Lys Leu  Ala Leu Glu 
    1370                 1375                 1380             


Arg Ala  Glu Glu Leu Cys Ser  Gln Val Asn Glu Gly  Val Arg Glu 
    1385                 1390                 1395             


Lys Glu  Asn Ser Asp Arg Leu  Glu Trp Ile Gln Ala  His Val Gln 
    1400                 1405                 1410             


Cys Glu  Gly Leu Ala Glu Gln  Leu Ile Phe Asn Ser  Leu Thr Asn 
    1415                 1420                 1425             


Cys Leu  Gly Pro Arg Lys Leu  Leu His Ser Gly Lys  Leu Tyr Lys 
    1430                 1435                 1440             


Thr Lys  Ser Asn Lys Glu Leu  His Gly Phe Leu Phe  Asn Asp Phe 
    1445                 1450                 1455             


Leu Leu  Leu Thr Tyr Met Val  Lys Gln Phe Ala Val  Ser Ser Gly 
    1460                 1465                 1470             


Ser Glu  Lys Leu Phe Ser Ser  Lys Ser Asn Ala Gln  Phe Lys Met 
    1475                 1480                 1485             


Tyr Lys  Thr Pro Ile Phe Leu  Asn Glu Val Leu Val  Lys Leu Pro 
    1490                 1495                 1500             


Thr Asp  Pro Ser Ser Asp Glu  Pro Val Phe His Ile  Ser His Ile 
    1505                 1510                 1515             


Asp Arg  Val Tyr Thr Leu Arg  Thr Asp Asn Ile Asn  Glu Arg Thr 
    1520                 1525                 1530             


Ala Trp  Val Gln Lys Ile Lys  Ala Ala Ser Glu Gln  Tyr Ile Asp 
    1535                 1540                 1545             


Thr Glu  Lys Lys Lys Arg Glu  Lys Ala Tyr Gln Ala  Arg Ser Gln 
    1550                 1555                 1560             


Lys Thr  Ser Gly Ile Gly Arg  Leu Met Val His Val  Ile Glu Ala 
    1565                 1570                 1575             


Thr Glu  Leu Lys Ala Cys Lys  Pro Asn Gly Lys Ser  Asn Pro Tyr 
    1580                 1585                 1590             


Cys Glu  Ile Ser Met Gly Ser  Gln Ser Tyr Thr Thr  Arg Thr Ile 
    1595                 1600                 1605             


Gln Asp  Thr Leu Asn Pro Lys  Trp Asn Phe Asn Cys  Gln Phe Phe 
    1610                 1615                 1620             


Ile Lys  Asp Leu Tyr Gln Asp  Val Leu Cys Leu Thr  Leu Phe Asp 
    1625                 1630                 1635             


Arg Asp  Gln Phe Ser Pro Asp  Asp Phe Leu Gly Arg  Thr Glu Ile 
    1640                 1645                 1650             


Pro Val  Ala Lys Ile Arg Thr  Glu Gln Glu Ser Lys  Gly Pro Met 
    1655                 1660                 1665             


Thr Arg  Arg Leu Leu Leu His  Glu Val Pro Thr Gly  Glu Val Trp 
    1670                 1675                 1680             


Val Arg  Phe Asp Leu Gln Leu  Phe Glu Gln Lys Thr  Leu Leu 
    1685                 1690                 1695         


<210>  5653
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVD__Homo_sapiens__NP_001152980

<400>  5653

Met Ala Glu Met Ala Thr Ala Thr Arg Leu Leu Gly Trp Arg Val Ala 
1               5                   10                  15      


Ser Trp Arg Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala 
            20                  25                  30          


His Ser Leu Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu 
        35                  40                  45              


Gln Arg Gln Glu Phe Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly 
    50                  55                  60                  


Ile Thr Ala Pro Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu 
65                  70                  75                  80  


His Val Leu Val Met Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly 
                85                  90                  95      


Leu Ser Tyr Gly Ala His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg 
            100                 105                 110         


Asn Gly Asn Glu Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser 
        115                 120                 125             


Gly Glu Tyr Ile Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser 
    130                 135                 140                 


Asp Val Val Ser Met Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr 
145                 150                 155                 160 


Ile Leu Asn Gly Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp 
                165                 170                 175     


Val Leu Ile Val Tyr Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser 
            180                 185                 190         


Arg Gly Ile Thr Ala Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser 
        195                 200                 205             


Thr Ser Lys Lys Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys 
    210                 215                 220                 


Glu Leu Ile Phe Glu Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly 
225                 230                 235                 240 


His Glu Asn Lys Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu 
                245                 250                 255     


Arg Leu Val Leu Ala Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu 
            260                 265                 270         


Asp His Thr Ile Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys 
        275                 280                 285             


Ile Gly His Phe Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr 
    290                 295                 300                 


Arg Leu Met Ala Cys Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys 
305                 310                 315                 320 


Asp Glu Gly His Cys Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr 
                325                 330                 335     


Ser Ala Glu Cys Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe 
            340                 345                 350         


Gly Gly Asn Gly Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg 
        355                 360                 365             


Asp Ala Lys Leu Tyr Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg 
    370                 375                 380                 


Leu Val Ile Gly Arg Ala Phe Asn Ala Asp Phe His 
385                 390                 395     


<210>  5654
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVL__Homo_sapiens__XP_006711363

<400>  5654

Met Ser Gln Gln His Thr Leu Pro Val Thr Leu Ser Pro Ala Leu Ser 
1               5                   10                  15      


Gln Glu Leu Leu Lys Thr Val Pro Pro Pro Val Asn Thr His Gln Glu 
            20                  25                  30          


Gln Met Lys Gln Pro Thr Pro Leu Pro Pro Pro Cys Gln Lys Val Pro 
        35                  40                  45              


Val Glu Leu Pro Val Glu Val Pro Ser Lys Gln Glu Glu Lys His Met 
    50                  55                  60                  


Thr Ala Val Lys Gly Leu Pro Glu Gln Glu Cys Glu Gln Gln Gln Lys 
65                  70                  75                  80  


Glu Pro Gln Glu Gln Glu Leu Gln Gln Gln His Trp Glu Gln His Glu 
                85                  90                  95      


Glu Tyr Gln Lys Ala Glu Asn Pro Glu Gln Gln Leu Lys Gln Glu Lys 
            100                 105                 110         


Thr Gln Arg Asp Gln Gln Leu Asn Lys Gln Leu Glu Glu Glu Lys Lys 
        115                 120                 125             


Leu Leu Asp Gln Gln Leu Asp Gln Glu Leu Val Lys Arg Asp Glu Gln 
    130                 135                 140                 


Leu Gly Met Lys Lys Glu Gln Leu Leu Glu Leu Pro Glu Gln Gln Glu 
145                 150                 155                 160 


Gly His Leu Lys His Leu Glu Gln Gln Glu Gly Gln Leu Lys His Pro 
                165                 170                 175     


Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln 
            180                 185                 190         


Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln 
        195                 200                 205             


Gln Glu Gly Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu 
    210                 215                 220                 


Leu Pro Glu Gln Gln Glu Gly Gln Leu Glu Leu Pro Gln Gln Gln Glu 
225                 230                 235                 240 


Gly Gln Leu Glu Leu Ser Glu Gln Gln Glu Gly Gln Leu Glu Leu Ser 
                245                 250                 255     


Glu Gln Gln Glu Gly Gln Leu Lys His Leu Glu His Gln Glu Gly Gln 
            260                 265                 270         


Leu Glu Val Pro Glu Glu Gln Met Gly Gln Leu Lys Tyr Leu Glu Gln 
        275                 280                 285             


Gln Glu Gly Gln Leu Lys His Leu Asp Gln Gln Glu Lys Gln Pro Glu 
    290                 295                 300                 


Leu Pro Glu Gln Gln Met Gly Gln Leu Lys His Leu Glu Gln Gln Glu 
305                 310                 315                 320 


Gly Gln Pro Lys His Leu Glu Gln Gln Glu Gly Gln Leu Glu Gln Leu 
                325                 330                 335     


Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly Gln 
            340                 345                 350         


Leu Glu His Leu Glu His Gln Glu Gly Gln Leu Gly Leu Pro Glu Gln 
        355                 360                 365             


Gln Val Leu Gln Leu Lys Gln Leu Glu Lys Gln Gln Gly Gln Pro Lys 
    370                 375                 380                 


His Leu Glu Glu Glu Glu Gly Gln Leu Lys His Leu Val Gln Gln Glu 
385                 390                 395                 400 


Gly Gln Leu Lys His Leu Val Gln Gln Glu Gly Gln Leu Glu Gln Gln 
                405                 410                 415     


Glu Arg Gln Val Glu His Leu Glu Gln Gln Val Gly Gln Leu Lys His 
            420                 425                 430         


Leu Glu Glu Gln Glu Gly Gln Leu Lys His Leu Glu Gln Gln Gln Gly 
        435                 440                 445             


Gln Leu Glu Val Pro Glu Gln Gln Val Gly Gln Pro Lys Asn Leu Glu 
    450                 455                 460                 


Gln Glu Glu Lys Gln Leu Glu Leu Pro Glu Gln Gln Glu Gly Gln Val 
465                 470                 475                 480 


Lys His Leu Glu Lys Gln Glu Ala Gln Leu Glu Leu Pro Glu Gln Gln 
                485                 490                 495     


Val Gly Gln Pro Lys His Leu Glu Gln Gln Glu Lys His Leu Glu His 
            500                 505                 510         


Pro Glu Gln Gln Asp Gly Gln Leu Lys His Leu Glu Gln Gln Glu Gly 
        515                 520                 525             


Gln Leu Lys Asp Leu Glu Gln Gln Lys Gly Gln Leu Glu Gln Pro Val 
    530                 535                 540                 


Phe Ala Pro Ala Pro Gly Gln Val Gln Asp Ile Gln Pro Ala Leu Pro 
545                 550                 555                 560 


Thr Lys Gly Glu Val Leu Leu Pro Val Glu His Gln Gln Gln Lys Gln 
                565                 570                 575     


Glu Val Gln Trp Pro Pro Lys His Lys 
            580                 585 


<210>  5655
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IVNS1ABP__Homo_sapiens__NP_006460

<400>  5655

Met Ile Pro Asn Gly Tyr Leu Met Phe Glu Asp Glu Asn Phe Ile Glu 
1               5                   10                  15      


Ser Ser Val Ala Lys Leu Asn Ala Leu Arg Lys Ser Gly Gln Phe Cys 
            20                  25                  30          


Asp Val Arg Leu Gln Val Cys Gly His Glu Met Leu Ala His Arg Ala 
        35                  40                  45              


Val Leu Ala Cys Cys Ser Pro Tyr Leu Phe Glu Ile Phe Asn Ser Asp 
    50                  55                  60                  


Ser Asp Pro His Gly Ile Ser His Val Lys Phe Asp Asp Leu Asn Pro 
65                  70                  75                  80  


Glu Ala Val Glu Val Leu Leu Asn Tyr Ala Tyr Thr Ala Gln Leu Lys 
                85                  90                  95      


Ala Asp Lys Glu Leu Val Lys Asp Val Tyr Ser Ala Ala Lys Lys Leu 
            100                 105                 110         


Lys Met Asp Arg Val Lys Gln Val Cys Gly Asp Tyr Leu Leu Ser Arg 
        115                 120                 125             


Met Asp Val Thr Ser Cys Ile Ser Tyr Arg Asn Phe Ala Ser Cys Met 
    130                 135                 140                 


Gly Asp Ser Arg Leu Leu Asn Lys Val Asp Ala Tyr Ile Gln Glu His 
145                 150                 155                 160 


Leu Leu Gln Ile Ser Glu Glu Glu Glu Phe Leu Lys Leu Pro Arg Leu 
                165                 170                 175     


Lys Leu Glu Val Met Leu Glu Asp Asn Val Cys Leu Pro Ser Asn Gly 
            180                 185                 190         


Lys Leu Tyr Thr Lys Val Ile Asn Trp Val Gln Arg Ser Ile Trp Glu 
        195                 200                 205             


Asn Gly Asp Ser Leu Glu Glu Leu Met Glu Glu Val Gln Thr Leu Tyr 
    210                 215                 220                 


Tyr Ser Ala Asp His Lys Leu Leu Asp Gly Asn Leu Leu Asp Gly Gln 
225                 230                 235                 240 


Ala Glu Val Phe Gly Ser Asp Asp Asp His Ile Gln Phe Val Gln Lys 
                245                 250                 255     


Lys Pro Pro Arg Glu Asn Gly His Lys Gln Ile Ser Ser Ser Ser Thr 
            260                 265                 270         


Gly Cys Leu Ser Ser Pro Asn Ala Thr Val Gln Ser Pro Lys His Glu 
        275                 280                 285             


Trp Lys Ile Val Ala Ser Glu Lys Thr Ser Asn Asn Thr Tyr Leu Cys 
    290                 295                 300                 


Leu Ala Val Leu Asp Gly Ile Phe Cys Val Ile Phe Leu His Gly Arg 
305                 310                 315                 320 


Asn Ser Pro Gln Ser Ser Pro Thr Ser Thr Pro Lys Leu Ser Lys Ser 
                325                 330                 335     


Leu Ser Phe Glu Met Gln Gln Asp Glu Leu Ile Glu Lys Pro Met Ser 
            340                 345                 350         


Pro Met Gln Tyr Ala Arg Ser Gly Leu Gly Thr Ala Glu Met Asn Gly 
        355                 360                 365             


Lys Leu Ile Ala Ala Gly Gly Tyr Asn Arg Glu Glu Cys Leu Arg Thr 
    370                 375                 380                 


Val Glu Cys Tyr Asn Pro His Thr Asp His Trp Ser Phe Leu Ala Pro 
385                 390                 395                 400 


Met Arg Thr Pro Arg Ala Arg Phe Gln Met Ala Val Leu Met Gly Gln 
                405                 410                 415     


Leu Tyr Val Val Gly Gly Ser Asn Gly His Ser Asp Asp Leu Ser Cys 
            420                 425                 430         


Gly Glu Met Tyr Asp Ser Asn Ile Asp Asp Trp Ile Pro Val Pro Glu 
        435                 440                 445             


Leu Arg Thr Asn Arg Cys Asn Ala Gly Val Cys Ala Leu Asn Gly Lys 
    450                 455                 460                 


Leu Tyr Ile Val Gly Gly Ser Asp Pro Tyr Gly Gln Lys Gly Leu Lys 
465                 470                 475                 480 


Asn Cys Asp Val Phe Asp Pro Val Thr Lys Leu Trp Thr Ser Cys Ala 
                485                 490                 495     


Pro Leu Asn Ile Arg Arg His Gln Ser Ala Val Cys Glu Leu Gly Gly 
            500                 505                 510         


Tyr Leu Tyr Ile Ile Gly Gly Ala Glu Ser Trp Asn Cys Leu Asn Thr 
        515                 520                 525             


Val Glu Arg Tyr Asn Pro Glu Asn Asn Thr Trp Thr Leu Ile Ala Pro 
    530                 535                 540                 


Met Asn Val Ala Arg Arg Gly Ala Gly Val Ala Val Leu Asn Gly Lys 
545                 550                 555                 560 


Leu Phe Val Cys Gly Gly Phe Asp Gly Ser His Ala Ile Ser Cys Val 
                565                 570                 575     


Glu Met Tyr Asp Pro Thr Arg Asn Glu Trp Lys Met Met Gly Asn Met 
            580                 585                 590         


Thr Ser Pro Arg Ser Asn Ala Gly Ile Ala Thr Val Gly Asn Thr Ile 
        595                 600                 605             


Tyr Ala Val Gly Gly Phe Asp Gly Asn Glu Phe Leu Asn Thr Val Glu 
    610                 615                 620                 


Val Tyr Asn Leu Glu Ser Asn Glu Trp Ser Pro Tyr Thr Lys Ile Phe 
625                 630                 635                 640 


Gln Phe 
        


<210>  5656
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IYD__Homo_sapiens__NP_001158166

<400>  5656

Met Tyr Phe Leu Thr Pro Ile Leu Val Ala Ile Leu Cys Ile Leu Val 
1               5                   10                  15      


Val Trp Ile Phe Lys Asn Ala Asp Arg Ser Met Glu Lys Lys Lys Gly 
            20                  25                  30          


Glu Pro Arg Thr Arg Ala Glu Ala Arg Pro Trp Val Asp Glu Asp Leu 
        35                  40                  45              


Lys Asp Ser Ser Asp Leu His Gln Ala Glu Glu Asp Ala Asp Glu Trp 
    50                  55                  60                  


Gln Glu Ser Glu Glu Asn Val Glu His Ile Pro Phe Ser His Asn His 
65                  70                  75                  80  


Tyr Pro Glu Lys Glu Met Val Lys Arg Ser Gln Glu Phe Tyr Glu Leu 
                85                  90                  95      


Leu Asn Lys Arg Arg Ser Val Arg Phe Ile Ser Asn Glu Gln Val Pro 
            100                 105                 110         


Met Glu Val Ile Asp Asn Val Ile Arg Thr Ala Gly Thr Ala Pro Ser 
        115                 120                 125             


Gly Ala His Thr Glu Pro Trp Thr Phe Val Val Val Lys Asp Pro Asp 
    130                 135                 140                 


Val Lys His Lys Ile Arg Lys Ile Ile Glu Glu Glu Glu Glu Ile Asn 
145                 150                 155                 160 


Tyr Met Lys Arg Met Gly His Arg Trp Val Thr Asp Leu Lys Lys Leu 
                165                 170                 175     


Arg Thr Asn Trp Ile Lys Glu Tyr Leu Asp Thr Ala Pro Ile Leu Ile 
            180                 185                 190         


Leu Ile Phe Lys Gln Val His Gly Phe Ala Ala Asn Gly Lys Lys Lys 
        195                 200                 205             


Val His Tyr Tyr Asn Glu Ile Ser Val Ser Ile Ala Cys Gly Ile Leu 
    210                 215                 220                 


Leu Ala Ala Leu Gln Val Asn Asn Gly Ile Thr Met Arg His Gln Thr 
225                 230                 235                 240 


Ala Arg His Arg His Leu Ile Glu Gly Pro Gly Arg Ser Ser Glu Ala 
                245                 250                 255     


Cys Ser Lys Leu Ser Ser Gln Gly Cys Pro Glu Cys Arg Ser Gly Asp 
            260                 265                 270         


Cys His Tyr His Ser Ser Gln Leu Trp Pro Ser Thr Glu Gly Ala Pro 
        275                 280                 285             


Gly Pro Pro Arg Thr 
    290             


<210>  5657
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IZUMO1__Homo_sapiens__XP_005258850

<400>  5657

Met Ser Val Leu Leu Leu Ser Val Trp Gly Glu Ser Thr Leu Pro Asn 
1               5                   10                  15      


Gly Leu Arg Glu Leu Cys Ala Pro Ala Ala Met Gly Pro His Phe Thr 
            20                  25                  30          


Leu Leu Cys Ala Ala Leu Ala Gly Cys Leu Leu Pro Ala Glu Gly Cys 
        35                  40                  45              


Val Ile Cys Asp Pro Ser Val Val Leu Ala Leu Lys Ser Leu Glu Lys 
    50                  55                  60                  


Asp Tyr Leu Pro Gly His Leu Asp Ala Lys His His Lys Ala Met Met 
65                  70                  75                  80  


Glu Arg Val Glu Asn Ala Val Lys Asp Phe Gln Glu Leu Ser Leu Asn 
                85                  90                  95      


Glu Asp Ala Tyr Met Gly Val Val Asp Glu Ala Thr Leu Gln Lys Gly 
            100                 105                 110         


Ser Trp Ser Leu Leu Lys Asp Leu Lys Arg Ile Thr Asp Ser Asp Val 
        115                 120                 125             


Lys Gly Asp Leu Phe Val Lys Glu Leu Phe Trp Met Leu His Leu Gln 
    130                 135                 140                 


Lys Glu Thr Phe Ala Thr Tyr Val Ala Arg Phe Gln Lys Glu Ala Tyr 
145                 150                 155                 160 


Cys Pro Asn Lys Cys Gly Val Met Leu Gln Thr Leu Ile Trp Cys Lys 
                165                 170                 175     


Asn Cys Lys Lys Glu Val His Ala Cys Arg Lys Ser Tyr Asp Cys Gly 
            180                 185                 190         


Glu Arg Asn Val Glu Val Pro Gln Met Glu Asp Met Ile Leu Asp Cys 
        195                 200                 205             


Glu Leu Asn Trp His Gln Ala Ser Glu Gly Leu Thr Asp Tyr Ser Phe 
    210                 215                 220                 


Tyr Arg Val Trp Gly Asn Asn Thr Glu Thr Leu Val Ser Lys Gly Lys 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Lys Pro Met Val Gly Pro Glu Asp Ala Gly Ser 
                245                 250                 255     


Tyr Arg Cys Glu Leu Gly Ser Val Asn Ser Ser Pro Ala Thr Ile Ile 
            260                 265                 270         


Asn Phe His Val Thr Val Leu Pro Lys Met Ile Lys Glu Glu Lys Pro 
        275                 280                 285             


Ser Pro Asn Ile Val Thr Pro Gly Glu Ala Thr Thr Glu Ser Ser Ile 
    290                 295                 300                 


Ser Leu Gln Pro Leu Gln Pro Glu Lys Met Leu Ala Ser Arg Leu Leu 
305                 310                 315                 320 


Gly Leu Leu Ile Cys Gly Ser Leu Ala Leu Ile Thr Gly Leu Thr Phe 
                325                 330                 335     


Ala Ile Phe Arg Arg Arg Lys Val Ile Asp Phe Ile Lys Ser Ser Leu 
            340                 345                 350         


Phe Gly Leu Gly Ser Gly Ala Ala Glu Gln Thr Gln Val Pro Lys Glu 
        355                 360                 365             


Lys Ala Thr Asp Ser Arg Gln Gln 
    370                 375     


<210>  5658
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JADE1__Homo_sapiens__NP_001274366

<400>  5658

Met Lys Arg Gly Arg Leu Pro Ser Ser Ser Glu Asp Ser Asp Asp Asn 
1               5                   10                  15      


Gly Ser Leu Ser Thr Thr Trp Ser Gln Asn Ser Arg Ser Gln His Arg 
            20                  25                  30          


Arg Ser Ser Cys Ser Arg His Glu Asp Arg Lys Pro Ser Glu Val Phe 
        35                  40                  45              


Arg Thr Asp Leu Ile Thr Ala Met Lys Leu His Asp Ser Tyr Gln Leu 
    50                  55                  60                  


Asn Pro Asp Glu Tyr Tyr Val Leu Ala Asp Pro Trp Arg Gln Glu Trp 
65                  70                  75                  80  


Glu Lys Gly Val Gln Val Pro Val Ser Pro Gly Thr Ile Pro Gln Pro 
                85                  90                  95      


Val Ala Arg Pro Lys Lys Tyr Ile Val Ser Ser Gly Ser Glu Pro Pro 
            100                 105                 110         


Glu Leu Gly Tyr Val Asp Ile Arg Thr Leu Ala Asp Ser Val Cys Arg 
        115                 120                 125             


Tyr Asp Leu Asn Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu 
    130                 135                 140                 


Glu Phe Lys Glu Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu 
145                 150                 155                 160 


Arg Val Leu Glu Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His 
                165                 170                 175     


Ala Ile Glu Thr Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val 
            180                 185                 190         


Val Cys Asp Val Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met 
        195                 200                 205             


Val Phe Cys Asp Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly 
    210                 215                 220                 


Ile Leu Lys Val Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu 
225                 230                 235                 240 


Gly Val Gln Pro Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met 
                245                 250                 255     


Lys Pro Thr Arg Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu 
            260                 265                 270         


Trp Ile Pro Glu Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile 
        275                 280                 285             


Thr Lys Val Ser His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser 
    290                 295                 300                 


Leu Cys Asn Glu Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn 
305                 310                 315                 320 


Cys Arg Thr Ala Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu 
                325                 330                 335     


Met Lys Thr Ile Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr 
            340                 345                 350         


Cys Pro Lys His Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys 
        355                 360                 365             


Gly Ala Ala Gln Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro 
    370                 375                 380                 


Leu Glu Pro Phe Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg 
385                 390                 395                 400 


Val Ser Val Arg Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr 
                405                 410                 415     


Thr Phe Val Asn Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu 
            420                 425                 430         


Glu Val Val Asp Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val 
        435                 440                 445             


Asn Phe Asn Lys Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn 
    450                 455                 460                 


Leu Ala Lys Arg Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe 
465                 470                 475                 480 


Thr His Leu Arg Gln Asp Leu Glu Arg Val Arg Asn Leu Thr Tyr Met 
                485                 490                 495     


Val Thr Arg Arg Glu Lys Ile Lys Arg Ser Val Cys Lys Val Gln Glu 
            500                 505                 510         


Gln Ile Phe Asn Leu Tyr Thr Lys Leu Leu Glu Gln Glu Arg Val Ser 
        515                 520                 525             


Gly Val Pro Ser Ser Cys Ser Ser Ser Ser Leu Glu Asn Met Leu Leu 
    530                 535                 540                 


Phe Asn Ser Pro Ser Val Gly Pro Asp Ala Pro Lys Ile Glu Asp Leu 
545                 550                 555                 560 


Lys Trp His Ser Ala Phe Phe Arg Lys Gln Met Gly Thr Ser Leu Val 
                565                 570                 575     


His Ser Leu Lys Lys Pro His Lys Arg Asp Pro Leu Gln Asn Ser Pro 
            580                 585                 590         


Gly Ser Glu Gly Lys Thr Leu Leu Lys Gln Pro Asp Leu Cys Gly Arg 
        595                 600                 605             


Arg Glu Gly Met Val Val Pro Glu Ser Phe Leu Gly Leu Glu Lys Thr 
    610                 615                 620                 


Phe Ala Glu Ala Arg Leu Ile Ser Ala Gln Gln Lys Asn Gly Val Val 
625                 630                 635                 640 


Met Pro Asp His Gly Lys Arg Arg Asp Asn Arg Phe His Cys Asp Leu 
                645                 650                 655     


Ile Lys Gly Asp Leu Lys Asp Lys Ser Phe Lys Gln Ser His Lys Pro 
            660                 665                 670         


Leu Arg Ser Thr Asp Val Ser Gln Arg His Leu Asp Asn Thr Arg Ala 
        675                 680                 685             


Ala Thr Ser Pro Gly Val Gly Gln Ser Ala Pro Gly Thr Arg Lys Glu 
    690                 695                 700                 


Ile Val Pro Lys Cys Asn Gly Ser Leu Ile Lys Val Asn Tyr Asn Gln 
705                 710                 715                 720 


Thr Ala Val Lys Val Pro Thr Thr Pro Ala Ser Pro Val Lys Asn Trp 
                725                 730                 735     


Gly Gly Phe Arg Ile Pro Lys Lys Gly Glu Arg Gln Gln Gln Gly Glu 
            740                 745                 750         


Ala His Asp Gly Ala Cys His Gln His Ser Asp Tyr Pro Tyr Leu Gly 
        755                 760                 765             


Leu Gly Arg Val Pro Ala Lys Glu Arg Ala Lys Ser Lys Leu Lys Ser 
    770                 775                 780                 


Asp Asn Glu Asn Asp Gly Tyr Val Pro Asp Val Glu Met Ser Asp Ser 
785                 790                 795                 800 


Glu Ser Glu Ala Ser Glu Lys Lys Cys Ile His Thr Ser Ser Thr Ile 
                805                 810                 815     


Ser Arg Arg Thr Asp Ile Ile Arg Arg Ser Ile Leu Ala Ser 
            820                 825                 830 


<210>  5659
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JADE2__Homo_sapiens__NP_001276914

<400>  5659

Met Val Pro Thr Ala Ala Ile Ala Val Gly Gly Tyr Phe Leu Gly Gly 
1               5                   10                  15      


Met Glu Glu Lys Arg Arg Lys Tyr Ser Ile Ser Ser Asp Asn Ser Asp 
            20                  25                  30          


Thr Thr Asp Ser His Ala Thr Ser Thr Ser Ala Ser Arg Cys Ser Lys 
        35                  40                  45              


Leu Pro Ser Ser Thr Lys Ser Gly Trp Pro Arg Gln Asn Glu Lys Lys 
    50                  55                  60                  


Pro Ser Glu Val Phe Arg Thr Asp Leu Ile Thr Ala Met Lys Ile Pro 
65                  70                  75                  80  


Asp Ser Tyr Gln Leu Ser Pro Asp Asp Tyr Tyr Ile Leu Ala Asp Pro 
                85                  90                  95      


Trp Arg Gln Glu Trp Glu Lys Gly Val Gln Val Pro Ala Gly Ala Glu 
            100                 105                 110         


Ala Ile Pro Glu Pro Val Val Arg Ile Leu Pro Pro Leu Glu Gly Pro 
        115                 120                 125             


Pro Ala Gln Ala Ser Pro Ser Ser Thr Met Leu Gly Glu Gly Ser Gln 
    130                 135                 140                 


Pro Asp Trp Pro Gly Gly Ser Arg Tyr Asp Leu Asp Glu Ile Asp Ala 
145                 150                 155                 160 


Tyr Trp Leu Glu Leu Ile Asn Ser Glu Leu Lys Glu Met Glu Arg Pro 
                165                 170                 175     


Glu Leu Asp Glu Leu Thr Leu Glu Arg Val Leu Glu Glu Leu Glu Thr 
            180                 185                 190         


Leu Cys His Gln Asn Met Ala Arg Ala Ile Glu Thr Gln Glu Gly Leu 
        195                 200                 205             


Gly Ile Glu Tyr Asp Glu Asp Val Val Cys Asp Val Cys Arg Ser Pro 
    210                 215                 220                 


Glu Gly Glu Asp Gly Asn Glu Met Val Phe Cys Asp Lys Cys Asn Val 
225                 230                 235                 240 


Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val Pro Thr Gly Ser 
                245                 250                 255     


Trp Leu Cys Arg Thr Cys Ala Leu Gly Val Gln Pro Lys Cys Leu Leu 
            260                 265                 270         


Cys Pro Lys Arg Gly Gly Ala Leu Lys Pro Thr Arg Ser Gly Thr Lys 
        275                 280                 285             


Trp Val His Val Ser Cys Ala Leu Trp Ile Pro Glu Val Ser Ile Gly 
    290                 295                 300                 


Cys Pro Glu Lys Met Glu Pro Ile Thr Lys Ile Ser His Ile Pro Ala 
305                 310                 315                 320 


Ser Arg Trp Ala Leu Ser Cys Ser Leu Cys Lys Glu Cys Thr Gly Thr 
                325                 330                 335     


Cys Ile Gln Cys Ser Met Pro Ser Cys Val Thr Ala Phe His Val Thr 
            340                 345                 350         


Cys Ala Phe Asp His Gly Leu Glu Met Arg Thr Ile Leu Ala Asp Asn 
        355                 360                 365             


Asp Glu Val Lys Phe Lys Ser Phe Cys Gln Glu His Ser Asp Gly Gly 
    370                 375                 380                 


Pro Arg Asn Glu Pro Thr Ser Glu Pro Thr Glu Pro Ser Gln Ala Gly 
385                 390                 395                 400 


Glu Asp Leu Glu Lys Val Thr Leu Arg Lys Gln Arg Leu Gln Gln Leu 
                405                 410                 415     


Glu Glu Asp Phe Tyr Glu Leu Val Glu Pro Ala Glu Val Ala Glu Arg 
            420                 425                 430         


Leu Asp Leu Ala Glu Ala Leu Val Asp Phe Ile Tyr Gln Tyr Trp Lys 
        435                 440                 445             


Leu Lys Arg Lys Ala Asn Ala Asn Gln Pro Leu Leu Thr Pro Lys Thr 
    450                 455                 460                 


Asp Glu Val Asp Asn Leu Ala Gln Gln Glu Gln Asp Val Leu Tyr Arg 
465                 470                 475                 480 


Arg Leu Lys Leu Phe Thr His Leu Arg Gln Asp Leu Glu Arg Val Arg 
                485                 490                 495     


Asn Leu Cys Tyr Met Val Thr Arg Arg Glu Arg Thr Lys His Ala Ile 
            500                 505                 510         


Cys Lys Leu Gln Glu Gln Ile Phe His Leu Gln Met Lys Leu Ile Glu 
        515                 520                 525             


Gln Asp Leu Cys Arg Glu Arg Ser Gly Arg Arg Ala Lys Gly Lys Lys 
    530                 535                 540                 


Ser Asp Ser Lys Arg Lys Gly Cys Glu Gly Ser Lys Gly Ser Thr Glu 
545                 550                 555                 560 


Lys Lys Glu Lys Val Lys Ala Gly Pro Asp Ser Val Leu Gly Gln Leu 
                565                 570                 575     


Ala Gly Leu Ser Thr Ser Phe Pro Ile Asp Gly Thr Phe Phe Asn Ser 
            580                 585                 590         


Trp Leu Ala Gln Ser Val Gln Ile Thr Ala Glu Asn Met Ala Met Ser 
        595                 600                 605             


Glu Trp Pro Leu Asn Asn Gly His Arg Glu Asp Pro Ala Pro Gly Leu 
    610                 615                 620                 


Leu Ser Glu Glu Leu Leu Gln Asp Glu Glu Thr Leu Leu Ser Phe Met 
625                 630                 635                 640 


Arg Asp Pro Ser Leu Arg Pro Gly Asp Pro Ala Arg Lys Ala Arg Gly 
                645                 650                 655     


Arg Thr Arg Leu Pro Ala Lys Lys Lys Pro Pro Pro Pro Pro Pro Gln 
            660                 665                 670         


Asp Gly Pro Gly Ser Arg Thr Thr Pro Asp Lys Ala Pro Lys Lys Thr 
        675                 680                 685             


Trp Gly Gln Asp Ala Gly Ser Gly Lys Gly Gly Gln Gly Pro Pro Thr 
    690                 695                 700                 


Arg Lys Pro Pro Arg Arg Thr Ser Ser His Leu Pro Ser Ser Pro Ala 
705                 710                 715                 720 


Ala Gly Asp Cys Pro Ile Leu Ala Thr Pro Glu Ser Pro Pro Pro Leu 
                725                 730                 735     


Ala Pro Glu Thr Pro Asp Glu Ala Ala Ser Val Ala Ala Asp Ser Asp 
            740                 745                 750         


Val Gln Val Pro Gly Pro Ala Ala Ser Pro Lys Pro Leu Gly Arg Leu 
        755                 760                 765             


Arg Pro Pro Arg Glu Ser Lys Val Thr Arg Arg Leu Pro Gly Ala Arg 
    770                 775                 780                 


Pro Asp Ala Gly Met Gly Pro Pro Ser Ala Val Ala Glu Arg Pro Lys 
785                 790                 795                 800 


Val Ser Leu His Phe Asp Thr Glu Thr Asp Gly Tyr Phe Ser Asp Gly 
                805                 810                 815     


Glu Met Ser Asp Ser Asp Val Glu Ala Glu Asp Gly Gly Val Gln Arg 
            820                 825                 830         


Gly Pro Arg Glu Ala Gly Ala Glu Glu Val Val Arg Met Gly Val Leu 
        835                 840                 845             


Ala Ser 
    850 


<210>  5660
<211>  1218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAG1__Homo_sapiens__NP_000205

<400>  5660

Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210>  5661
<211>  1238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAG2__Homo_sapiens__NP_002217

<400>  5661

Met Arg Ala Gln Gly Arg Gly Arg Leu Pro Arg Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Trp Val Gln Ala Ala Arg Pro Met Gly Tyr Phe Glu Leu 
            20                  25                  30          


Gln Leu Ser Ala Leu Arg Asn Val Asn Gly Glu Leu Leu Ser Gly Ala 
        35                  40                  45              


Cys Cys Asp Gly Asp Gly Arg Thr Thr Arg Ala Gly Gly Cys Gly His 
    50                  55                  60                  


Asp Glu Cys Asp Thr Tyr Val Arg Val Cys Leu Lys Glu Tyr Gln Ala 
65                  70                  75                  80  


Lys Val Thr Pro Thr Gly Pro Cys Ser Tyr Gly His Gly Ala Thr Pro 
                85                  90                  95      


Val Leu Gly Gly Asn Ser Phe Tyr Leu Pro Pro Ala Gly Ala Ala Gly 
            100                 105                 110         


Asp Arg Ala Arg Ala Arg Ala Arg Ala Gly Gly Asp Gln Asp Pro Gly 
        115                 120                 125             


Leu Val Val Ile Pro Phe Gln Phe Ala Trp Pro Arg Ser Phe Thr Leu 
    130                 135                 140                 


Ile Val Glu Ala Trp Asp Trp Asp Asn Asp Thr Thr Pro Asn Glu Glu 
145                 150                 155                 160 


Leu Leu Ile Glu Arg Val Ser His Ala Gly Met Ile Asn Pro Glu Asp 
                165                 170                 175     


Arg Trp Lys Ser Leu His Phe Ser Gly His Val Ala His Leu Glu Leu 
            180                 185                 190         


Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr Tyr Ser Ala Thr Cys Asn 
        195                 200                 205             


Lys Phe Cys Arg Pro Arg Asn Asp Phe Phe Gly His Tyr Thr Cys Asp 
    210                 215                 220                 


Gln Tyr Gly Asn Lys Ala Cys Met Asp Gly Trp Met Gly Lys Glu Cys 
225                 230                 235                 240 


Lys Glu Ala Val Cys Lys Gln Gly Cys Asn Leu Leu His Gly Gly Cys 
                245                 250                 255     


Thr Val Pro Gly Glu Cys Arg Cys Ser Tyr Gly Trp Gln Gly Arg Phe 
            260                 265                 270         


Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys Val His Gly Ser Cys Val 
        275                 280                 285             


Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn Trp Gly Gly Leu Leu Cys 
    290                 295                 300                 


Asp Lys Asp Leu Asn Tyr Cys Gly Ser His His Pro Cys Thr Asn Gly 
305                 310                 315                 320 


Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln Tyr Arg Cys Thr Cys Pro 
                325                 330                 335     


Asp Gly Tyr Ser Gly Arg Asn Cys Glu Lys Ala Glu His Ala Cys Thr 
            340                 345                 350         


Ser Asn Pro Cys Ala Asn Gly Gly Ser Cys His Glu Val Pro Ser Gly 
        355                 360                 365             


Phe Glu Cys His Cys Pro Ser Gly Trp Ser Gly Pro Thr Cys Ala Leu 
    370                 375                 380                 


Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Ala Ala Gly Gly Thr Cys 
385                 390                 395                 400 


Val Asp Gln Val Asp Gly Phe Glu Cys Ile Cys Pro Glu Gln Trp Val 
                405                 410                 415     


Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu Cys Glu Gly Lys Pro Cys 
            420                 425                 430         


Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile Gly Gly Tyr Tyr Cys Asp 
        435                 440                 445             


Cys Ile Pro Gly Trp Lys Gly Ile Asn Cys His Ile Asn Val Asn Asp 
    450                 455                 460                 


Cys Arg Gly Gln Cys Gln His Gly Gly Thr Cys Lys Asp Leu Val Asn 
465                 470                 475                 480 


Gly Tyr Gln Cys Val Cys Pro Arg Gly Phe Gly Gly Arg His Cys Glu 
                485                 490                 495     


Leu Glu Arg Asp Glu Cys Ala Ser Ser Pro Cys His Ser Gly Gly Leu 
            500                 505                 510         


Cys Glu Asp Leu Ala Asp Gly Phe His Cys His Cys Pro Gln Gly Phe 
        515                 520                 525             


Ser Gly Pro Leu Cys Glu Val Asp Val Asp Leu Cys Glu Pro Ser Pro 
    530                 535                 540                 


Cys Arg Asn Gly Ala Arg Cys Tyr Asn Leu Glu Gly Asp Tyr Tyr Cys 
545                 550                 555                 560 


Ala Cys Pro Asp Asp Phe Gly Gly Lys Asn Cys Ser Val Pro Arg Glu 
                565                 570                 575     


Pro Cys Pro Gly Gly Ala Cys Arg Val Ile Asp Gly Cys Gly Ser Asp 
            580                 585                 590         


Ala Gly Pro Gly Met Pro Gly Thr Ala Ala Ser Gly Val Cys Gly Pro 
        595                 600                 605             


His Gly Arg Cys Val Ser Gln Pro Gly Gly Asn Phe Ser Cys Ile Cys 
    610                 615                 620                 


Asp Ser Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile Asp Asp Cys 
625                 630                 635                 640 


Leu Gly Gln Pro Cys Arg Asn Gly Gly Thr Cys Ile Asp Glu Val Asp 
                645                 650                 655     


Ala Phe Arg Cys Phe Cys Pro Ser Gly Trp Glu Gly Glu Leu Cys Asp 
            660                 665                 670         


Thr Asn Pro Asn Asp Cys Leu Pro Asp Pro Cys His Ser Arg Gly Arg 
        675                 680                 685             


Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys Ala Cys Asp Asp Gly Trp 
    690                 695                 700                 


Lys Gly Lys Thr Cys His Ser Arg Glu Phe Gln Cys Asp Ala Tyr Thr 
705                 710                 715                 720 


Cys Ser Asn Gly Gly Thr Cys Tyr Asp Ser Gly Asp Thr Phe Arg Cys 
                725                 730                 735     


Ala Cys Pro Pro Gly Trp Lys Gly Ser Thr Cys Ala Val Ala Lys Asn 
            740                 745                 750         


Ser Ser Cys Leu Pro Asn Pro Cys Val Asn Gly Gly Thr Cys Val Gly 
        755                 760                 765             


Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg Asp Gly Trp Glu Gly Arg 
    770                 775                 780                 


Thr Cys Thr His Asn Thr Asn Asp Cys Asn Pro Leu Pro Cys Tyr Asn 
785                 790                 795                 800 


Gly Gly Ile Cys Val Asp Gly Val Asn Trp Phe Arg Cys Glu Cys Ala 
                805                 810                 815     


Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile Asn Ile Asp Glu Cys Gln 
            820                 825                 830         


Ser Ser Pro Cys Ala Tyr Gly Ala Thr Cys Val Asp Glu Ile Asn Gly 
        835                 840                 845             


Tyr Arg Cys Ser Cys Pro Pro Gly Arg Ala Gly Pro Arg Cys Gln Glu 
    850                 855                 860                 


Val Ile Gly Phe Gly Arg Ser Cys Trp Ser Arg Gly Thr Pro Phe Pro 
865                 870                 875                 880 


His Gly Ser Ser Trp Val Glu Asp Cys Asn Ser Cys Arg Cys Leu Asp 
                885                 890                 895     


Gly Arg Arg Asp Cys Ser Lys Val Trp Cys Gly Trp Lys Pro Cys Leu 
            900                 905                 910         


Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala Gln Cys Pro Leu Gly Gln 
        915                 920                 925             


Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys Leu Arg Pro Pro Cys Glu 
    930                 935                 940                 


Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro Pro Ser Thr Pro Cys Leu 
945                 950                 955                 960 


Pro Arg Ser Gly His Leu Asp Asn Asn Cys Ala Arg Leu Thr Leu His 
                965                 970                 975     


Phe Asn Arg Asp His Val Pro Gln Gly Thr Thr Val Gly Ala Ile Cys 
            980                 985                 990         


Ser Gly Ile Arg Ser Leu Pro Ala  Thr Arg Ala Val Ala  Arg Asp Arg 
        995                 1000                 1005             


Leu Leu  Val Leu Leu Cys Asp  Arg Ala Ser Ser Gly  Ala Ser Ala 
    1010                 1015                 1020             


Val Glu  Val Ala Val Ser Phe  Ser Pro Ala Arg Asp  Leu Pro Asp 
    1025                 1030                 1035             


Ser Ser  Leu Ile Gln Gly Ala  Ala His Ala Ile Val  Ala Ala Ile 
    1040                 1045                 1050             


Thr Gln  Arg Gly Asn Ser Ser  Leu Leu Leu Ala Val  Thr Glu Val 
    1055                 1060                 1065             


Lys Val  Glu Thr Val Val Thr  Gly Gly Ser Ser Thr  Gly Leu Leu 
    1070                 1075                 1080             


Val Pro  Val Leu Cys Gly Ala  Phe Ser Val Leu Trp  Leu Ala Cys 
    1085                 1090                 1095             


Val Val  Leu Cys Val Trp Trp  Thr Arg Lys Arg Arg  Lys Glu Arg 
    1100                 1105                 1110             


Glu Arg  Ser Arg Leu Pro Arg  Glu Glu Ser Ala Asn  Asn Gln Trp 
    1115                 1120                 1125             


Ala Pro  Leu Asn Pro Ile Arg  Asn Pro Ile Glu Arg  Pro Gly Gly 
    1130                 1135                 1140             


His Lys  Asp Val Leu Tyr Gln  Cys Lys Asn Phe Thr  Pro Pro Pro 
    1145                 1150                 1155             


Arg Arg  Ala Asp Glu Ala Leu  Pro Gly Pro Ala Gly  His Ala Ala 
    1160                 1165                 1170             


Val Arg  Glu Asp Glu Glu Asp  Glu Asp Leu Gly Arg  Gly Glu Glu 
    1175                 1180                 1185             


Asp Ser  Leu Glu Ala Glu Lys  Phe Leu Ser His Lys  Phe Thr Lys 
    1190                 1195                 1200             


Asp Pro  Gly Arg Ser Pro Gly  Arg Pro Ala His Trp  Ala Ser Gly 
    1205                 1210                 1215             


Pro Lys  Val Asp Asn Arg Ala  Val Arg Ser Ile Asn  Glu Ala Arg 
    1220                 1225                 1230             


Tyr Ala  Gly Lys Glu 
    1235             


<210>  5662
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAGN1__Homo_sapiens__NP_115881

<400>  5662

Met Ala Ser Arg Ala Gly Pro Arg Ala Ala Gly Thr Asp Gly Ser Asp 
1               5                   10                  15      


Phe Gln His Arg Glu Arg Val Ala Met His Tyr Gln Met Ser Val Thr 
            20                  25                  30          


Leu Lys Tyr Glu Ile Lys Lys Leu Ile Tyr Val His Leu Val Ile Trp 
        35                  40                  45              


Leu Leu Leu Val Ala Lys Met Ser Val Gly His Leu Arg Leu Leu Ser 
    50                  55                  60                  


His Asp Gln Val Ala Met Pro Tyr Gln Trp Glu Tyr Pro Tyr Leu Leu 
65                  70                  75                  80  


Ser Ile Leu Pro Ser Leu Leu Gly Leu Leu Ser Phe Pro Arg Asn Asn 
                85                  90                  95      


Ile Ser Tyr Leu Val Leu Ser Met Ile Ser Met Gly Leu Phe Ser Ile 
            100                 105                 110         


Ala Pro Leu Ile Tyr Gly Ser Met Glu Met Phe Pro Ala Ala Gln Gln 
        115                 120                 125             


Leu Tyr Arg His Gly Lys Ala Tyr Arg Phe Leu Phe Gly Phe Ser Ala 
    130                 135                 140                 


Val Ser Ile Met Tyr Leu Val Leu Val Leu Ala Val Gln Val His Ala 
145                 150                 155                 160 


Trp Gln Leu Tyr Tyr Ser Lys Lys Leu Leu Asp Ser Trp Phe Thr Ser 
                165                 170                 175     


Thr Gln Glu Lys Lys His Lys 
            180             


<210>  5663
<211>  1132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2__Homo_sapiens__NP_004963

<400>  5663

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Arg Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Val Val Thr Ile His Lys Gln Asp Gly Lys Asn Leu 
            340                 345                 350         


Glu Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu 
        355                 360                 365             


Ile Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys 
    370                 375                 380                 


Lys Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys 
385                 390                 395                 400 


His Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala 
                405                 410                 415     


Gly Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe 
            420                 425                 430         


Asn Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu 
        435                 440                 445             


Tyr Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu 
    450                 455                 460                 


Ser Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys 
465                 470                 475                 480 


Tyr Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr 
                485                 490                 495     


Lys Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe 
            500                 505                 510         


Arg Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg 
        515                 520                 525             


Pro Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp 
    530                 535                 540                 


Leu Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe 
545                 550                 555                 560 


Lys Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr 
                565                 570                 575     


Glu Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu 
            580                 585                 590         


Ser Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His 
        595                 600                 605             


Leu Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu 
    610                 615                 620                 


Val Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys 
625                 630                 635                 640 


Asn Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln 
                645                 650                 655     


Leu Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly 
            660                 665                 670         


Asn Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys 
        675                 680                 685             


Thr Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile 
    690                 695                 700                 


Thr Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro 
705                 710                 715                 720 


Pro Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys 
                725                 730                 735     


Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys 
            740                 745                 750         


Pro Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp 
        755                 760                 765             


Arg His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile 
    770                 775                 780                 


Asn Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala 
785                 790                 795                 800 


Ile Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu 
                805                 810                 815     


Thr Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe 
            820                 825                 830         


Ser Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His 
        835                 840                 845             


Leu Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
    850                 855                 860                 


Met Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Val Val Ala 
865                 870                 875                 880 


Val Lys Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu 
                885                 890                 895     


Arg Glu Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys 
            900                 905                 910         


Tyr Lys Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile 
        915                 920                 925             


Met Glu Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His 
    930                 935                 940                 


Lys Glu Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile 
945                 950                 955                 960 


Cys Lys Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp 
                965                 970                 975     


Leu Ala Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile 
            980                 985                 990         


Gly Asp Phe Gly Leu Thr Lys Val  Leu Pro Gln Asp Lys  Glu Tyr Tyr 
        995                 1000                 1005             


Lys Val  Lys Glu Pro Gly Glu  Ser Pro Ile Phe Trp  Tyr Ala Pro 
    1010                 1015                 1020             


Glu Ser  Leu Thr Glu Ser Lys  Phe Ser Val Ala Ser  Asp Val Trp 
    1025                 1030                 1035             


Ser Phe  Gly Val Val Leu Tyr  Glu Leu Phe Thr Tyr  Ile Glu Lys 
    1040                 1045                 1050             


Ser Lys  Ser Pro Pro Ala Glu  Phe Met Arg Met Ile  Gly Asn Asp 
    1055                 1060                 1065             


Lys Gln  Gly Gln Met Ile Val  Phe His Leu Ile Glu  Leu Leu Lys 
    1070                 1075                 1080             


Asn Asn  Gly Arg Leu Pro Arg  Pro Asp Gly Cys Pro  Asp Glu Ile 
    1085                 1090                 1095             


Tyr Met  Ile Met Thr Glu Cys  Trp Asn Asn Asn Val  Asn Gln Arg 
    1100                 1105                 1110             


Pro Ser  Phe Arg Asp Leu Ala  Leu Arg Val Asp Gln  Ile Arg Asp 
    1115                 1120                 1125             


Asn Met  Ala Gly 
    1130         


<210>  5664
<211>  1167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3__Homo_sapiens__XP_005259953

<400>  5664

Met Thr Val Ala Gln Glu Thr Lys Gly Pro Thr Gln Glu Gly Ala Glu 
1               5                   10                  15      


Trp Asp Phe Pro Leu Ala Ala Ser Arg Leu Cys Pro Pro Phe Glu Ser 
            20                  25                  30          


Pro Gly Ser Leu Pro Ala Arg Gln Val Ala Leu Met Ala Pro Pro Ser 
        35                  40                  45              


Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys Ser Leu Leu Ser Thr 
    50                  55                  60                  


Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala Arg Gly Pro Gly Pro 
65                  70                  75                  80  


Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His Leu Ala Glu Asp Leu 
                85                  90                  95      


Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu Pro Val Tyr His Ser 
            100                 105                 110         


Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys Trp Phe Pro Pro Ser 
        115                 120                 125             


His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln Val Leu Leu Tyr Arg 
    130                 135                 140                 


Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu Glu Lys Cys His Arg 
145                 150                 155                 160 


Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile Leu Asp Leu Pro Val 
                165                 170                 175     


Leu Glu His Leu Phe Ala Gln His Arg Ser Asp Leu Val Ser Gly Arg 
            180                 185                 190         


Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly Glu Cys Leu Ser Leu 
        195                 200                 205             


Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu Gln Ala Gln Arg Pro 
    210                 215                 220                 


Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala Cys Leu Pro Pro Ser 
225                 230                 235                 240 


Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val Thr Arg Arg Arg Ile 
                245                 250                 255     


Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val Ala Ala Cys Gln Ala 
            260                 265                 270         


Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met Asp Leu Glu Arg Leu 
        275                 280                 285             


Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val Gly Leu Pro Gly Ala 
    290                 295                 300                 


Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg Val Ala Gly Asp Gly 
305                 310                 315                 320 


Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val Leu Gln Pro Phe Cys 
                325                 330                 335     


Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys Gln Ala Pro Arg Val 
            340                 345                 350         


Gly Pro Ala Gly Glu His Arg Leu Val Thr Val Thr Arg Thr Asp Asn 
        355                 360                 365             


Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro Glu Ala Leu Ser Phe 
    370                 375                 380                 


Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr Thr Asp Ser Gln His 
385                 390                 395                 400 


Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu Leu Glu Glu Val Ala 
                405                 410                 415     


Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe Ala Ile Asn Lys Leu 
            420                 425                 430         


Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val Leu Arg Arg Ser Pro 
        435                 440                 445             


Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys Val Gln Asn Pro Leu 
    450                 455                 460                 


Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg Ser Pro Thr Gly Thr 
465                 470                 475                 480 


Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser Ser Leu Arg Glu Leu 
                485                 490                 495     


Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val Asp Gly Val Ala Val 
            500                 505                 510         


Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys Glu Lys Ser Asn Leu 
        515                 520                 525             


Ile Val Val Gln Arg Gly His Ser Pro Pro Thr Ser Ser Leu Val Gln 
    530                 535                 540                 


Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr Phe His Lys Ile Pro 
545                 550                 555                 560 


Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly His Gly Ser Phe Thr 
                565                 570                 575     


Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val Asp Gly Glu Ala Arg 
            580                 585                 590         


Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala Lys His Lys Asn Cys 
        595                 600                 605             


Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met Ser Gln Val Ser Tyr 
    610                 615                 620                 


Arg His Leu Val Leu Leu His Gly Val Cys Met Ala Gly Asp Ser Thr 
625                 630                 635                 640 


Met Val Gln Glu Phe Val His Leu Gly Ala Ile Asp Met Tyr Leu Arg 
                645                 650                 655     


Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys Leu Gln Val Val Lys 
            660                 665                 670         


Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp Lys Gly Leu Pro His 
        675                 680                 685             


Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala Arg Glu Gly Ala Asp 
    690                 695                 700                 


Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Val Ser Pro Ala 
705                 710                 715                 720 


Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile Pro Trp Val Ala Pro 
                725                 730                 735     


Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu Glu Ala Asp Lys Trp 
            740                 745                 750         


Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser Gly Val Thr Met Pro 
        755                 760                 765             


Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln Phe Tyr Glu Asp Arg 
    770                 775                 780                 


Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu Ala Leu Leu Ile Gln 
785                 790                 795                 800 


Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro Ser Phe Arg Ala Val 
                805                 810                 815     


Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp Tyr Glu Leu Leu Ser 
            820                 825                 830         


Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp Gly Leu Trp Asn Gly 
        835                 840                 845             


Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile Phe Glu Glu Arg His 
    850                 855                 860                 


Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu 
865                 870                 875                 880 


Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr Gly Ala Leu Val Ala 
                885                 890                 895     


Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln Gln Arg Asp Phe Gln 
            900                 905                 910         


Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser Asp Phe Ile Val Lys 
        915                 920                 925             


Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln Ser Leu Arg Leu Val 
    930                 935                 940                 


Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp Phe Leu Gln Arg His 
945                 950                 955                 960 


Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu Tyr Ser Ser Gln Ile 
                965                 970                 975     


Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg Cys Val His Arg Asp 
            980                 985                 990         


Leu Ala Ala Arg Asn Ile Leu Val  Glu Ser Glu Ala His  Val Lys Ile 
        995                 1000                 1005             


Ala Asp  Phe Gly Leu Ala Lys  Leu Leu Pro Leu Asp  Lys Asp Tyr 
    1010                 1015                 1020             


Tyr Val  Val Arg Glu Pro Gly  Gln Ser Pro Ile Phe  Trp Tyr Ala 
    1025                 1030                 1035             


Pro Glu  Ser Leu Ser Asp Asn  Ile Phe Ser Arg Gln  Ser Asp Val 
    1040                 1045                 1050             


Trp Ser  Phe Gly Val Val Leu  Tyr Glu Leu Phe Thr  Tyr Cys Asp 
    1055                 1060                 1065             


Lys Ser  Cys Ser Pro Ser Ala  Glu Phe Leu Arg Met  Met Gly Cys 
    1070                 1075                 1080             


Glu Arg  Asp Val Pro Ala Leu  Cys Arg Leu Leu Glu  Leu Leu Glu 
    1085                 1090                 1095             


Glu Gly  Gln Arg Leu Pro Ala  Pro Pro Ala Cys Pro  Ala Glu Val 
    1100                 1105                 1110             


His Glu  Leu Met Lys Leu Cys  Trp Ala Pro Ser Pro  Gln Asp Arg 
    1115                 1120                 1125             


Pro Ser  Phe Ser Ala Leu Gly  Pro Gln Leu Asp Met  Leu Trp Ser 
    1130                 1135                 1140             


Gly Ser  Arg Gly Cys Glu Thr  His Ala Phe Thr Ala  His Pro Glu 
    1145                 1150                 1155             


Gly Lys  His His Ser Leu Ser  Phe Ser 
    1160                 1165         


<210>  5665
<211>  831
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAKMIP1__Homo_sapiens__NP_001092903

<400>  5665

Met Ser Lys Lys Gly Arg Ser Lys Gly Glu Lys Pro Glu Met Glu Thr 
1               5                   10                  15      


Asp Ala Val Gln Met Ala Asn Glu Glu Leu Arg Ala Lys Leu Thr Ser 
            20                  25                  30          


Ile Gln Ile Glu Phe Gln Gln Glu Lys Ser Lys Val Gly Lys Leu Arg 
        35                  40                  45              


Glu Arg Leu Gln Glu Ala Lys Leu Glu Arg Glu Gln Glu Gln Arg Arg 
    50                  55                  60                  


His Thr Ala Tyr Ile Ser Glu Leu Lys Ala Lys Leu His Glu Glu Lys 
65                  70                  75                  80  


Thr Lys Glu Leu Gln Ala Leu Arg Glu Gly Leu Ile Arg Gln His Glu 
                85                  90                  95      


Gln Glu Ala Ala Arg Thr Ala Lys Ile Lys Glu Gly Glu Leu Gln Arg 
            100                 105                 110         


Leu Gln Ala Thr Leu Asn Val Leu Arg Asp Gly Ala Ala Asp Lys Val 
        115                 120                 125             


Lys Thr Ala Leu Leu Thr Glu Ala Arg Glu Glu Ala Arg Arg Ala Phe 
    130                 135                 140                 


Asp Gly Glu Arg Leu Arg Leu Gln Gln Glu Ile Leu Glu Leu Lys Ala 
145                 150                 155                 160 


Ala Arg Lys Gln Ala Glu Glu Ala Leu Ser Asn Cys Met Gln Ala Asp 
                165                 170                 175     


Lys Thr Lys Ala Ala Asp Leu Arg Ala Ala Tyr Gln Ala His Gln Asp 
            180                 185                 190         


Glu Val His Arg Ile Lys Arg Glu Cys Glu Arg Asp Ile Arg Arg Leu 
        195                 200                 205             


Met Asp Glu Ile Lys Gly Lys Asp Arg Val Ile Leu Ala Leu Glu Lys 
    210                 215                 220                 


Glu Leu Gly Val Gln Ala Gly Gln Thr Gln Lys Leu Leu Leu Gln Lys 
225                 230                 235                 240 


Glu Ala Leu Asp Glu Gln Leu Val Gln Val Lys Glu Ala Glu Arg His 
                245                 250                 255     


His Ser Ser Pro Lys Arg Glu Leu Pro Pro Gly Ile Gly Asp Met Val 
            260                 265                 270         


Glu Leu Met Gly Val Gln Asp Gln His Met Asp Glu Arg Asp Val Arg 
        275                 280                 285             


Arg Phe Gln Leu Lys Ile Ala Glu Leu Asn Ser Val Ile Arg Lys Leu 
    290                 295                 300                 


Glu Asp Arg Asn Thr Leu Leu Ala Asp Glu Arg Asn Glu Leu Leu Lys 
305                 310                 315                 320 


Arg Ser Arg Glu Thr Glu Val Gln Leu Lys Pro Leu Val Glu Lys Asn 
                325                 330                 335     


Lys Arg Met Asn Lys Lys Asn Glu Asp Leu Leu Gln Ser Ile Gln Arg 
            340                 345                 350         


Met Glu Glu Lys Ile Lys Asn Leu Thr Arg Glu Asn Val Glu Met Lys 
        355                 360                 365             


Glu Lys Leu Ser Ala Gln Ala Ser Leu Lys Arg His Thr Ser Leu Asn 
    370                 375                 380                 


Asp Leu Ser Leu Thr Arg Asp Glu Gln Glu Ile Glu Phe Leu Arg Leu 
385                 390                 395                 400 


Gln Val Leu Glu Gln Gln His Val Ile Asp Asp Leu Ser Leu Glu Arg 
                405                 410                 415     


Glu Arg Leu Leu Arg Ser Lys Arg His Arg Gly Lys Ser Leu Lys Pro 
            420                 425                 430         


Pro Lys Lys His Val Val Glu Thr Phe Phe Gly Phe Asp Glu Glu Ser 
        435                 440                 445             


Val Asp Ser Glu Thr Leu Ser Glu Thr Ser Tyr Asn Thr Asp Arg Thr 
    450                 455                 460                 


Asp Arg Thr Pro Ala Thr Pro Glu Glu Asp Leu Asp Asp Ala Thr Ala 
465                 470                 475                 480 


Arg Glu Glu Ala Asp Leu Arg Phe Cys Gln Leu Thr Arg Glu Tyr Gln 
                485                 490                 495     


Ala Leu Gln Arg Ala Tyr Ala Leu Leu Gln Glu Gln Val Gly Gly Thr 
            500                 505                 510         


Leu Asp Ala Glu Arg Glu Ala Arg Thr Arg Glu Gln Leu Gln Ala Asp 
        515                 520                 525             


Leu Leu Arg Cys Gln Ala Lys Ile Glu Asp Leu Glu Lys Leu Leu Val 
    530                 535                 540                 


Glu Lys Gly Gln Asp Ser Lys Trp Val Glu Glu Lys Gln Leu Leu Ile 
545                 550                 555                 560 


Arg Thr Asn Gln Asp Leu Leu Glu Lys Ile Tyr Arg Leu Glu Met Glu 
                565                 570                 575     


Glu Asn Gln Leu Lys Asn Glu Met Gln Asp Ala Lys Asp Gln Asn Glu 
            580                 585                 590         


Leu Leu Glu Phe Arg Val Leu Glu Leu Glu Glu Arg Glu Arg Arg Ser 
        595                 600                 605             


Pro Ala Phe Asn Leu Gln Ile Thr Thr Phe Pro Glu Asn His Ser Ser 
    610                 615                 620                 


Ala Leu Gln Leu Phe Cys His Gln Glu Gly Val Lys Asp Val Asn Val 
625                 630                 635                 640 


Ser Glu Leu Met Lys Lys Leu Asp Ile Leu Gly Asp Asn Gly Asn Leu 
                645                 650                 655     


Arg Asn Glu Glu Gln Val Ala Ile Ile Gln Ala Gly Thr Val Leu Ala 
            660                 665                 670         


Leu Cys Glu Lys Trp Leu Lys Gln Ile Glu Gly Thr Glu Ala Ala Leu 
        675                 680                 685             


Thr Gln Lys Met Leu Asp Leu Glu Lys Glu Lys Asp Leu Phe Ser Arg 
    690                 695                 700                 


Gln Lys Gly Tyr Leu Glu Glu Glu Leu Asp Tyr Arg Lys Gln Ala Leu 
705                 710                 715                 720 


Asp Gln Ala Tyr Leu Lys Ile Gln Asp Leu Glu Ala Thr Leu Tyr Thr 
                725                 730                 735     


Ala Leu Gln Gln Glu Pro Gly Arg Arg Ala Gly Glu Ala Leu Ser Glu 
            740                 745                 750         


Gly Gln Arg Glu Asp Leu Gln Ala Ala Val Glu Lys Val Arg Arg Gln 
        755                 760                 765             


Ile Leu Arg Gln Ser Arg Glu Phe Asp Ser Gln Ile Leu Arg Glu Arg 
    770                 775                 780                 


Met Glu Leu Leu Gln Gln Ala Gln Gln Arg Ile Arg Glu Leu Glu Asp 
785                 790                 795                 800 


Lys Leu Glu Phe Gln Lys Arg His Leu Lys Glu Leu Glu Glu Lys Phe 
                805                 810                 815     


Leu Phe Leu Phe Leu Phe Phe Ser Leu Ala Phe Ile Leu Trp Pro 
            820                 825                 830     


<210>  5666
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAKMIP2__Homo_sapiens__NP_001257863

<400>  5666

Met Ser Lys Lys Gly Arg Asn Lys Gly Glu Lys Pro Glu Ala Leu Ile 
1               5                   10                  15      


Val Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Thr Lys Leu Thr Asp 
            20                  25                  30          


Ile Gln Ile Glu Leu His Gln Glu Lys Ser Lys Val Ser Lys Leu Glu 
        35                  40                  45              


Arg Glu Lys Thr Gln Glu Ala Lys Arg Ile Arg Glu Leu Glu Gln Arg 
    50                  55                  60                  


Lys His Thr Val Leu Val Thr Glu Leu Lys Ala Lys Leu His Glu Glu 
65                  70                  75                  80  


Lys Met Lys Glu Leu Gln Ala Val Arg Glu Asn Leu Ile Lys Gln His 
                85                  90                  95      


Glu Gln Glu Met Ser Arg Thr Val Lys Val Arg Asp Gly Glu Ile Gln 
            100                 105                 110         


Arg Leu Lys Ser Ala Leu Cys Ala Leu Arg Asp Gly Ser Ser Asp Lys 
        115                 120                 125             


Val Arg Thr Ala Leu Thr Ile Glu Ala Arg Glu Glu Ala Arg Lys Leu 
    130                 135                 140                 


Phe Asp Thr Glu Arg Leu Lys Leu Leu Gln Glu Ile Ala Asp Leu Lys 
145                 150                 155                 160 


Thr Ala Lys Lys Gln Val Asp Glu Ala Leu Ser Asn Met Ile Gln Ala 
                165                 170                 175     


Asp Lys Ile Lys Ala Gly Asp Leu Arg Ser Glu His Gln Ser His Gln 
            180                 185                 190         


Glu Ala Ile Ser Lys Ile Lys Trp Glu Ser Glu Arg Asp Ile Arg Arg 
        195                 200                 205             


Leu Met Asp Glu Ile Lys Ala Lys Asp Arg Ile Ile Phe Ser Leu Glu 
    210                 215                 220                 


Lys Glu Leu Glu Thr Gln Thr Gly Tyr Val Gln Lys Leu Gln Leu Gln 
225                 230                 235                 240 


Lys Glu Ala Leu Asp Glu Gln Leu Phe Leu Val Lys Glu Ala Glu Cys 
                245                 250                 255     


Asn Met Ser Ser Pro Lys Arg Glu Ile Pro Gly Arg Ala Gly Asp Gly 
            260                 265                 270         


Ser Glu His Cys Ser Ser Pro Asp Leu Arg Arg Asn Gln Lys Arg Ile 
        275                 280                 285             


Ala Glu Leu Asn Ala Thr Ile Arg Lys Leu Glu Asp Arg Asn Thr Leu 
    290                 295                 300                 


Leu Gly Asp Glu Arg Asn Glu Leu Leu Lys Arg Val Arg Glu Thr Glu 
305                 310                 315                 320 


Lys Gln Cys Lys Pro Leu Leu Glu Arg Asn Lys Cys Leu Ala Lys Arg 
                325                 330                 335     


Asn Asp Glu Leu Met Val Ser Leu Gln Arg Met Glu Glu Lys Leu Lys 
            340                 345                 350         


Ala Val Thr Lys Glu Asn Ser Glu Met Arg Glu Lys Ile Thr Ser His 
        355                 360                 365             


Pro Pro Leu Lys Lys Leu Lys Ser Leu Asn Asp Leu Asp Gln Ala Asn 
    370                 375                 380                 


Glu Glu Gln Glu Thr Glu Phe Leu Lys Leu Gln Val Ile Glu Gln Gln 
385                 390                 395                 400 


Asn Ile Ile Asp Glu Leu Thr Arg Asp Arg Glu Lys Leu Ile Arg Arg 
                405                 410                 415     


Arg Lys His Arg Arg Ser Ser Lys Pro Ile Lys Arg Pro Val Leu Asp 
            420                 425                 430         


Pro Phe Ile Gly Tyr Asp Glu Asp Ser Met Asp Ser Glu Thr Ser Ser 
        435                 440                 445             


Met Ala Ser Phe Arg Thr Asp Arg Thr Pro Ala Thr Pro Asp Asp Asp 
    450                 455                 460                 


Leu Asp Glu Ser Leu Ala Ala Glu Glu Ser Glu Leu Arg Phe Arg Gln 
465                 470                 475                 480 


Leu Thr Lys Glu Tyr Gln Ala Leu Gln Arg Ala Tyr Ala Leu Leu Gln 
                485                 490                 495     


Glu Gln Thr Gly Gly Ile Ile Asp Ala Glu Arg Glu Ala Lys Ala Gln 
            500                 505                 510         


Glu Gln Leu Gln Ala Glu Val Leu Arg Tyr Lys Ala Lys Ile Glu Asp 
        515                 520                 525             


Leu Glu Ala Thr Leu Ala Gln Lys Gly Gln Ile Glu Lys Gln Glu Ala 
    530                 535                 540                 


Glu Asn His Arg Leu Gln Gln Glu Leu Gln Asp Ala Arg Asp Gln Asn 
545                 550                 555                 560 


Glu Leu Leu Glu Phe Arg Asn Leu Glu Leu Glu Glu Arg Glu Arg Arg 
                565                 570                 575     


Ser Pro Pro Phe Asn Leu Gln Ile His Pro Phe Ser Asp Gly Val Ser 
            580                 585                 590         


Ala Leu Gln Ile Tyr Cys Met Lys Glu Gly Val Lys Asp Val Asn Ile 
        595                 600                 605             


Pro Asp Leu Ile Lys Gln Leu Asp Ile Leu Gly Asp Asn Gly Asn Leu 
    610                 615                 620                 


Arg Asn Glu Glu Gln Val Ala Ile Ile Gln Ala Ser Thr Val Leu Ser 
625                 630                 635                 640 


Leu Ala Glu Lys Trp Ile Gln Gln Ile Glu Gly Ala Glu Ala Ala Leu 
                645                 650                 655     


His Gln Lys Met Met Glu Leu Glu Ser Asp Met Glu Gln Phe Cys Lys 
            660                 665                 670         


Ile Lys Gly Tyr Leu Glu Glu Glu Leu Asp Tyr Arg Lys Gln Ala Leu 
        675                 680                 685             


Asp Gln Ala Tyr Met Arg Ile Gln Glu Leu Glu Ala Thr Leu Tyr Asn 
    690                 695                 700                 


Ala Leu Gln Gln Glu Thr Val Ile Lys Phe Gly Glu Leu Leu Ser Glu 
705                 710                 715                 720 


Lys Gln Gln Glu Glu Leu Arg Thr Ala Val Glu Lys Leu Arg Arg Gln 
                725                 730                 735     


Met Leu Arg Lys Ser Arg Glu Tyr Asp Cys Gln Ile Leu Gln Glu Arg 
            740                 745                 750         


Met Glu Leu Leu Gln Gln Ala His Gln Arg Ile Arg Asp Leu Glu Asp 
        755                 760                 765             


Lys Thr Asp Ile Gln Lys Arg Gln Ile Lys Asp Leu Glu Glu Lys Phe 
    770                 775                 780                 


Leu Phe Leu Phe Leu Phe Phe Ser Leu Ala Phe Ile Leu Trp Pro 
785                 790                 795                 


<210>  5667
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAKMIP3__Homo_sapiens__XP_011537986

<400>  5667

Met Ser Lys Arg Gly Met Ser Ser Arg Ala Lys Gly Asp Lys Ala Glu 
1               5                   10                  15      


Ala Leu Ala Ala Leu Gln Ala Ala Asn Glu Asp Leu Arg Ala Lys Leu 
            20                  25                  30          


Thr Asp Ile Gln Ile Glu Leu Gln Gln Glu Lys Ser Lys Val Ser Lys 
        35                  40                  45              


Val Glu Arg Glu Lys Asn Gln Glu Leu Arg Gln Val Arg Glu His Glu 
    50                  55                  60                  


Gln His Lys Thr Ala Val Leu Leu Thr Glu Leu Lys Thr Lys Leu His 
65                  70                  75                  80  


Glu Glu Lys Met Lys Glu Leu Gln Ala Val Arg Glu Thr Leu Leu Arg 
                85                  90                  95      


Gln His Glu Ala Glu Leu Leu Arg Val Ile Lys Ile Lys Asp Asn Glu 
            100                 105                 110         


Asn Gln Arg Leu Gln Ala Leu Leu Ser Ala Leu Arg Asp Gly Gly Pro 
        115                 120                 125             


Glu Lys Val Lys Thr Val Leu Leu Ser Glu Ala Lys Glu Glu Ala Lys 
    130                 135                 140                 


Lys Gly Phe Glu Val Glu Lys Val Lys Met Gln Gln Glu Ile Ser Glu 
145                 150                 155                 160 


Leu Lys Gly Ala Lys Arg Gln Val Glu Glu Ala Leu Thr Leu Val Ile 
                165                 170                 175     


Gln Ala Asp Lys Ile Lys Ala Ala Glu Ile Arg Ser Val Tyr His Leu 
            180                 185                 190         


His Gln Glu Glu Ile Thr Arg Ile Lys Lys Glu Cys Glu Arg Glu Ile 
        195                 200                 205             


Arg Arg Leu Met Glu Glu Ile Lys Phe Lys Asp Arg Ala Val Phe Val 
    210                 215                 220                 


Leu Glu Arg Glu Leu Gly Val Gln Ala Gly His Ala Gln Arg Leu Gln 
225                 230                 235                 240 


Leu Gln Lys Glu Ala Leu Asp Glu Gln Leu Ser Gln Val Arg Glu Ala 
                245                 250                 255     


Asp Arg His Pro Gly Ser Pro Arg Arg Glu Leu Pro His Ala Ala Gly 
            260                 265                 270         


Ala Gly Asp Ala Ser Asp His Ser Gly Ser Pro Glu Gln Gln Leu Asp 
        275                 280                 285             


Glu Lys Asp Ala Arg Arg Phe Gln Leu Lys Ile Ala Glu Leu Ser Ala 
    290                 295                 300                 


Ile Ile Arg Lys Leu Glu Asp Arg Asn Ala Leu Leu Ser Glu Glu Arg 
305                 310                 315                 320 


Asn Glu Leu Leu Lys Arg Val Arg Glu Ala Glu Ser Gln Tyr Lys Pro 
                325                 330                 335     


Leu Leu Asp Lys Asn Lys Arg Leu Ser Arg Lys Asn Glu Asp Leu Ser 
            340                 345                 350         


His Ala Leu Arg Arg Met Glu Asn Lys Leu Lys Phe Val Thr Gln Glu 
        355                 360                 365             


Asn Ile Glu Met Arg Gln Arg Ala Gly Ile Ile Arg Arg Pro Ser Ser 
    370                 375                 380                 


Leu Asn Asp Leu Asp Gln Ser Gln Asp Glu Arg Glu Val Asp Phe Leu 
385                 390                 395                 400 


Lys Leu Gln Ile Val Glu Gln Gln Asn Leu Ile Asp Glu Leu Ser Lys 
                405                 410                 415     


Thr Leu Glu Thr Ala Gly Tyr Val Lys Ser Val Leu Glu Arg Asp Lys 
            420                 425                 430         


Leu Leu Arg Phe Arg Lys Gln Arg Lys Lys Met Ala Lys Leu Pro Lys 
        435                 440                 445             


Pro Val Val Val Glu Thr Phe Phe Gly Tyr Asp Glu Glu Ala Ser Leu 
    450                 455                 460                 


Glu Ser Asp Gly Ser Ser Val Ser Tyr Gln Thr Asp Arg Thr Asp Gln 
465                 470                 475                 480 


Thr Pro Cys Thr Pro Asp Asp Asp Leu Glu Glu Gly Met Ala Lys Glu 
                485                 490                 495     


Glu Thr Glu Leu Arg Phe Arg Gln Leu Thr Met Glu Tyr Gln Ala Leu 
            500                 505                 510         


Gln Arg Ala Tyr Ala Leu Leu Gln Glu Gln Val Gly Gly Thr Leu Asp 
        515                 520                 525             


Ala Glu Arg Glu Val Lys Thr Arg Glu Gln Leu Gln Ala Glu Val Gln 
    530                 535                 540                 


Arg Ala Gln Ala Arg Ile Glu Asp Leu Glu Lys Ala Leu Ala Glu Gln 
545                 550                 555                 560 


Gly Gln Asp Met Lys Trp Ile Glu Glu Lys Gln Ala Leu Tyr Arg Arg 
                565                 570                 575     


Asn Gln Glu Leu Val Glu Lys Ile Lys Gln Met Glu Thr Glu Glu Ala 
            580                 585                 590         


Arg Leu Arg His Glu Val Gln Asp Ala Arg Asp Gln Asn Glu Leu Leu 
        595                 600                 605             


Glu Phe Arg Ile Leu Glu Leu Glu Glu Arg Glu Arg Lys Ser Pro Ala 
    610                 615                 620                 


Ile Ser Phe His His Thr Pro Phe Val Asp Gly Lys Ser Pro Leu Gln 
625                 630                 635                 640 


Val Tyr Cys Glu Ala Glu Gly Val Thr Asp Ile Val Val Ala Glu Leu 
                645                 650                 655     


Met Lys Lys Leu Asp Ile Leu Gly Asp Asn Ala Asn Leu Thr Asn Glu 
            660                 665                 670         


Glu Gln Val Val Val Ile Gln Ala Arg Thr Val Leu Thr Leu Ala Glu 
        675                 680                 685             


Lys Trp Leu Gln Gln Ile Glu Glu Thr Glu Ala Ala Leu Gln Arg Lys 
    690                 695                 700                 


Met Val Asp Leu Glu Ser Glu Lys Glu Leu Phe Ser Lys Gln Lys Gly 
705                 710                 715                 720 


Tyr Leu Asp Glu Glu Leu Asp Tyr Arg Lys Gln Ala Leu Asp Gln Ala 
                725                 730                 735     


Asn Lys His Ile Leu Glu Leu Glu Ala Met Leu Tyr Asp Ala Leu Gln 
            740                 745                 750         


Gln Glu Ala Gly Ala Lys Val Ala Glu Leu Leu Ser Glu Glu Glu Arg 
        755                 760                 765             


Glu Lys Leu Lys Val Ala Val Glu Gln Trp Lys Arg Gln Val Met Ser 
    770                 775                 780                 


Glu Leu Arg Glu Arg Asp Ala Gln Ile Leu Arg Glu Arg Met Glu Leu 
785                 790                 795                 800 


Leu Gln Leu Ala Gln Gln Arg Ile Lys Glu Leu Glu Glu Arg Ile Glu 
                805                 810                 815     


Ala Gln Lys Arg Gln Ile Lys Glu Leu Glu Glu Lys Phe Leu Phe Leu 
            820                 825                 830         


Phe Leu Phe Phe Ser Leu Ala Phe Ile Leu Trp Ser 
        835                 840                 


<210>  5668
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAM2__Homo_sapiens__NP_001257336

<400>  5668

Met Ala Arg Arg Ser Arg His Arg Leu Leu Leu Leu Leu Leu Arg Tyr 
1               5                   10                  15      


Leu Val Val Ala Leu Gly Tyr His Lys Ala Tyr Gly Phe Ser Ala Pro 
            20                  25                  30          


Lys Asp Gln Gln Val Val Thr Ala Val Glu Tyr Gln Gly Asp Phe Lys 
        35                  40                  45              


Asn Arg Ala Glu Met Ile Asp Phe Asn Ile Arg Ile Lys Asn Val Thr 
    50                  55                  60                  


Arg Ser Asp Ala Gly Lys Tyr Arg Cys Glu Val Ser Ala Pro Ser Glu 
65                  70                  75                  80  


Gln Gly Gln Asn Leu Glu Glu Asp Thr Val Thr Leu Glu Val Leu Val 
                85                  90                  95      


Ala Pro Ala Val Pro Ser Cys Glu Val Pro Ser Ser Ala Leu Ser Gly 
            100                 105                 110         


Thr Val Val Glu Leu Arg Cys Gln Asp Lys Glu Gly Asn Pro Ala Pro 
        115                 120                 125             


Glu Tyr Thr Trp Phe Lys Asp Gly Ile Arg Leu Leu Glu Asn Pro Arg 
    130                 135                 140                 


Leu Gly Ser Gln Ser Thr Asn Ser Ser Tyr Thr Met Asn Thr Lys Thr 
145                 150                 155                 160 


Gly Thr Leu Gln Phe Asn Thr Val Ser Lys Leu Asp Thr Gly Glu Tyr 
                165                 170                 175     


Ser Cys Glu Ala Arg Asn Ser Val Gly Tyr Arg Arg Cys Pro Gly Lys 
            180                 185                 190         


Arg Met Gln Val Asp Asp Leu Asn Ile Ser Gly Ile Ile Ala Ala Val 
        195                 200                 205             


Val Val Val Ala Leu Val Ile Ser Val Cys Gly Leu Gly Val Cys Tyr 
    210                 215                 220                 


Ala Gln Arg Lys Gly Tyr Phe Ser Lys Glu Thr Ser Phe Gln Lys Ser 
225                 230                 235                 240 


Asn Ser Ser Ser Lys Ala Thr Thr Met Ser Glu Asn Asp Phe Lys His 
                245                 250                 255     


Thr Lys Ser Phe Ile Ile 
            260         


<210>  5669
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAM3__Homo_sapiens__NP_001192258

<400>  5669

Met Ala Leu Arg Arg Pro Pro Arg Leu Arg Leu Cys Ala Arg Leu Pro 
1               5                   10                  15      


Asp Phe Phe Leu Leu Leu Leu Phe Arg Gly Cys Leu Ile Gly Ala Val 
            20                  25                  30          


Asn Leu Lys Ser Ser Asn Arg Thr Pro Val Val Gln Glu Phe Glu Ser 
        35                  40                  45              


Val Glu Leu Ser Cys Ile Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg 
    50                  55                  60                  


Ile Glu Trp Lys Lys Ile Gln Asp Glu Gln Thr Thr Tyr Val Phe Phe 
65                  70                  75                  80  


Asp Asn Lys Ile Gln Val Lys Pro Val Thr Pro Val Cys Arg Val Pro 
                85                  90                  95      


Lys Ala Val Pro Val Gly Lys Met Ala Thr Leu His Cys Gln Glu Ser 
            100                 105                 110         


Glu Gly His Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn Asp Val Pro 
        115                 120                 125             


Leu Pro Thr Asp Ser Arg Ala Asn Pro Arg Phe Arg Asn Ser Ser Phe 
    130                 135                 140                 


His Leu Asn Ser Glu Thr Gly Thr Leu Val Phe Thr Ala Val His Lys 
145                 150                 155                 160 


Asp Asp Ser Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp Ala Gly Ser 
                165                 170                 175     


Ala Arg Cys Glu Glu Gln Glu Met Glu Val Tyr Asp Leu Asn Ile Gly 
            180                 185                 190         


Gly Ile Ile Gly Gly Val Leu Val Val Leu Ala Val Leu Ala Leu Ile 
        195                 200                 205             


Thr Leu Gly Ile Cys Cys Ala Tyr Arg Arg Gly Tyr Phe Ile Asn Asn 
    210                 215                 220                 


Lys Gln Asp Gly Glu Ser Tyr Lys Asn Pro Gly Lys Pro Asp Gly Val 
225                 230                 235                 240 


Asn Tyr Ile Arg Thr Asp Glu Glu Gly Asp Phe Arg His Lys Ser Ser 
                245                 250                 255     


Phe Val Ile 
            


<210>  5670
<211>  1074
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JARID2__Homo_sapiens__NP_001253969

<400>  5670

Met Val Tyr Phe Gly Ser Ser Gln Asp Glu Glu Glu Val Glu Glu Glu 
1               5                   10                  15      


Asp Asp Glu Thr Glu Asp Val Lys Thr Ala Thr Asn Asn Ala Ser Ser 
            20                  25                  30          


Ser Cys Gln Ser Thr Pro Arg Lys Gly Lys Thr His Lys His Val His 
        35                  40                  45              


Asn Gly His Val Phe Asn Gly Ser Ser Arg Ser Thr Arg Glu Lys Glu 
    50                  55                  60                  


Pro Val Gln Lys His Lys Ser Lys Glu Ala Thr Pro Ala Lys Glu Lys 
65                  70                  75                  80  


His Ser Asp His Arg Ala Asp Ser Arg Arg Glu Gln Ala Ser Ala Asn 
                85                  90                  95      


His Pro Ala Ala Ala Pro Ser Thr Gly Ser Ser Ala Lys Gly Leu Ala 
            100                 105                 110         


Ala Thr His His His Pro Pro Leu His Arg Ser Ala Gln Asp Leu Arg 
        115                 120                 125             


Lys Gln Val Ser Lys Val Asn Gly Val Thr Arg Met Ser Ser Leu Gly 
    130                 135                 140                 


Ala Gly Val Thr Ser Ala Lys Lys Met Arg Glu Val Arg Pro Ser Pro 
145                 150                 155                 160 


Ser Lys Thr Val Lys Tyr Thr Ala Thr Val Thr Lys Gly Ala Val Thr 
                165                 170                 175     


Tyr Thr Lys Ala Lys Arg Glu Leu Val Lys Asp Thr Lys Pro Asn His 
            180                 185                 190         


His Lys Pro Ser Ser Ala Val Asn His Thr Ile Ser Gly Lys Thr Glu 
        195                 200                 205             


Ser Ser Asn Ala Lys Thr Arg Lys Gln Val Leu Ser Leu Gly Gly Ala 
    210                 215                 220                 


Ser Lys Ser Thr Gly Pro Ala Val Asn Gly Leu Lys Val Ser Gly Arg 
225                 230                 235                 240 


Leu Asn Pro Lys Ser Cys Thr Lys Glu Val Gly Gly Arg Gln Leu Arg 
                245                 250                 255     


Glu Gly Leu Gln Leu Arg Glu Gly Leu Arg Asn Ser Lys Arg Arg Leu 
            260                 265                 270         


Glu Glu Ala His Gln Ala Glu Lys Pro Gln Ser Pro Pro Lys Lys Met 
        275                 280                 285             


Lys Gly Ala Ala Gly Pro Ala Glu Gly Pro Gly Lys Lys Ala Pro Ala 
    290                 295                 300                 


Glu Arg Gly Leu Leu Asn Gly His Val Lys Lys Glu Val Pro Glu Arg 
305                 310                 315                 320 


Ser Leu Glu Arg Asn Arg Pro Lys Arg Ala Thr Ala Gly Lys Ser Thr 
                325                 330                 335     


Pro Gly Arg Gln Ala His Gly Lys Ala Asp Ser Ala Ser Cys Glu Asn 
            340                 345                 350         


Arg Ser Thr Ser Gln Pro Glu Ser Val His Lys Pro Gln Asp Ser Gly 
        355                 360                 365             


Lys Ala Glu Lys Gly Gly Gly Lys Ala Gly Trp Ala Ala Met Asp Glu 
    370                 375                 380                 


Ile Pro Val Leu Arg Pro Ser Ala Lys Glu Phe His Asp Pro Leu Ile 
385                 390                 395                 400 


Tyr Ile Glu Ser Val Arg Ala Gln Val Glu Lys Phe Gly Met Cys Arg 
                405                 410                 415     


Val Ile Pro Pro Pro Asp Trp Arg Pro Glu Cys Lys Leu Asn Asp Glu 
            420                 425                 430         


Met Arg Phe Val Thr Gln Ile Gln His Ile His Lys Leu Gly Arg Arg 
        435                 440                 445             


Trp Gly Pro Asn Val Gln Arg Leu Ala Cys Ile Lys Lys His Leu Lys 
    450                 455                 460                 


Ser Gln Gly Ile Thr Met Asp Glu Leu Pro Leu Ile Gly Gly Cys Glu 
465                 470                 475                 480 


Leu Asp Leu Ala Cys Phe Phe Arg Leu Ile Asn Glu Met Gly Gly Met 
                485                 490                 495     


Gln Gln Val Thr Asp Leu Lys Lys Trp Asn Lys Leu Ala Asp Met Leu 
            500                 505                 510         


Arg Ile Pro Arg Thr Ala Gln Asp Arg Leu Ala Lys Leu Gln Glu Ala 
        515                 520                 525             


Tyr Cys Gln Tyr Leu Leu Ser Tyr Asp Ser Leu Ser Pro Glu Glu His 
    530                 535                 540                 


Arg Arg Leu Glu Lys Glu Val Leu Met Glu Lys Glu Ile Leu Glu Lys 
545                 550                 555                 560 


Arg Lys Gly Pro Leu Glu Gly His Thr Glu Asn Asp His His Lys Phe 
                565                 570                 575     


His Pro Leu Pro Arg Phe Glu Pro Lys Asn Gly Leu Ile His Gly Val 
            580                 585                 590         


Ala Pro Arg Asn Gly Phe Arg Ser Lys Leu Lys Glu Val Gly Gln Ala 
        595                 600                 605             


Gln Leu Lys Thr Gly Arg Arg Arg Leu Phe Ala Gln Glu Lys Glu Val 
    610                 615                 620                 


Val Lys Glu Glu Glu Glu Asp Lys Gly Val Leu Asn Asp Phe His Lys 
625                 630                 635                 640 


Cys Ile Tyr Lys Gly Arg Ser Val Ser Leu Thr Thr Phe Tyr Arg Thr 
                645                 650                 655     


Ala Arg Asn Ile Met Ser Met Cys Phe Ser Lys Glu Pro Ala Pro Ala 
            660                 665                 670         


Glu Ile Glu Gln Glu Tyr Trp Arg Leu Val Glu Glu Lys Asp Cys His 
        675                 680                 685             


Val Ala Val His Cys Gly Lys Val Asp Thr Asn Thr His Gly Ser Gly 
    690                 695                 700                 


Phe Pro Val Gly Lys Ser Glu Pro Phe Ser Arg His Gly Trp Asn Leu 
705                 710                 715                 720 


Thr Val Leu Pro Asn Asn Thr Gly Ser Ile Leu Arg His Leu Gly Ala 
                725                 730                 735     


Val Pro Gly Val Thr Ile Pro Trp Leu Asn Ile Gly Met Val Phe Ser 
            740                 745                 750         


Thr Ser Cys Trp Ser Arg Asp Gln Asn His Leu Pro Tyr Ile Asp Tyr 
        755                 760                 765             


Leu His Thr Gly Ala Asp Cys Ile Trp Tyr Cys Ile Pro Ala Glu Glu 
    770                 775                 780                 


Glu Asn Lys Leu Glu Asp Val Val His Thr Leu Leu Gln Ala Asn Gly 
785                 790                 795                 800 


Thr Pro Gly Leu Gln Met Leu Glu Ser Asn Val Met Ile Ser Pro Glu 
                805                 810                 815     


Val Leu Cys Lys Glu Gly Ile Lys Val His Arg Thr Val Gln Gln Ser 
            820                 825                 830         


Gly Gln Phe Val Val Cys Phe Pro Gly Ser Phe Val Ser Lys Val Cys 
        835                 840                 845             


Cys Gly Tyr Ser Val Ser Glu Thr Val His Phe Ala Thr Thr Gln Trp 
    850                 855                 860                 


Thr Ser Met Gly Phe Glu Thr Ala Lys Glu Met Lys Arg Arg His Ile 
865                 870                 875                 880 


Ala Lys Pro Phe Ser Met Glu Lys Leu Leu Tyr Gln Ile Ala Gln Ala 
                885                 890                 895     


Glu Ala Lys Lys Glu Asn Gly Pro Thr Leu Ser Thr Ile Ser Ala Leu 
            900                 905                 910         


Leu Asp Glu Leu Arg Asp Thr Glu Leu Arg Gln Arg Arg Gln Leu Phe 
        915                 920                 925             


Glu Ala Gly Leu His Ser Ser Ala Arg Tyr Gly Ser His Asp Gly Ser 
    930                 935                 940                 


Ser Thr Val Ala Asp Gly Lys Lys Lys Pro Arg Lys Trp Leu Gln Leu 
945                 950                 955                 960 


Glu Thr Ser Glu Arg Arg Cys Gln Ile Cys Gln His Leu Cys Tyr Leu 
                965                 970                 975     


Ser Met Val Val Gln Glu Asn Glu Asn Val Val Phe Cys Leu Glu Cys 
            980                 985                 990         


Ala Leu Arg His Val Glu Lys Gln  Lys Ser Cys Arg Gly  Leu Lys Leu 
        995                 1000                 1005             


Met Tyr  Arg Tyr Asp Glu Glu  Gln Ile Ile Ser Leu  Val Asn Gln 
    1010                 1015                 1020             


Ile Cys  Gly Lys Val Ser Gly  Lys Asn Gly Ser Ile  Glu Asn Cys 
    1025                 1030                 1035             


Leu Ser  Lys Pro Thr Pro Lys  Arg Gly Pro Arg Lys  Arg Ala Thr 
    1040                 1045                 1050             


Val Asp  Val Pro Pro Ser Arg  Leu Ser Ala Ser Ser  Ser Ser Lys 
    1055                 1060                 1065             


Ser Ala  Ser Ser Ser Ser 
    1070                 


<210>  5671
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAZF1__Homo_sapiens__NP_778231

<400>  5671

Met Thr Gly Ile Ala Ala Ala Ser Phe Phe Ser Asn Thr Cys Arg Phe 
1               5                   10                  15      


Gly Gly Cys Gly Leu His Phe Pro Thr Leu Ala Asp Leu Ile Glu His 
            20                  25                  30          


Ile Glu Asp Asn His Ile Asp Thr Asp Pro Arg Val Leu Glu Lys Gln 
        35                  40                  45              


Glu Leu Gln Gln Pro Thr Tyr Val Ala Leu Ser Tyr Ile Asn Arg Phe 
    50                  55                  60                  


Met Thr Asp Ala Ala Arg Arg Glu Gln Glu Ser Leu Lys Lys Lys Ile 
65                  70                  75                  80  


Gln Pro Lys Leu Ser Leu Thr Leu Ser Ser Ser Val Ser Arg Gly Asn 
                85                  90                  95      


Val Ser Thr Pro Pro Arg His Ser Ser Gly Ser Leu Thr Pro Pro Val 
            100                 105                 110         


Thr Pro Pro Ile Thr Pro Ser Ser Ser Phe Arg Ser Ser Thr Pro Thr 
        115                 120                 125             


Gly Ser Glu Tyr Asp Glu Glu Glu Val Asp Tyr Glu Glu Ser Asp Ser 
    130                 135                 140                 


Asp Glu Ser Trp Thr Thr Glu Ser Ala Ile Ser Ser Glu Ala Ile Leu 
145                 150                 155                 160 


Ser Ser Met Cys Met Asn Gly Gly Glu Glu Lys Pro Phe Ala Cys Pro 
                165                 170                 175     


Val Pro Gly Cys Lys Lys Arg Tyr Lys Asn Val Asn Gly Ile Lys Tyr 
            180                 185                 190         


His Ala Lys Asn Gly His Arg Thr Gln Ile Arg Val Arg Lys Pro Phe 
        195                 200                 205             


Lys Cys Arg Cys Gly Lys Ser Tyr Lys Thr Ala Gln Gly Leu Arg His 
    210                 215                 220                 


His Thr Ile Asn Phe His Pro Pro Val Ser Ala Glu Ile Ile Arg Lys 
225                 230                 235                 240 


Met Gln Gln 
            


<210>  5672
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JDP2__Homo_sapiens__XP_005267389

<400>  5672

Met Met Pro Gly Gln Ile Pro Asp Pro Ser Val Thr Thr Gly Ser Leu 
1               5                   10                  15      


Pro Gly Leu Gly Pro Leu Thr Gly Leu Pro Ser Ser Ala Leu Thr Val 
            20                  25                  30          


Glu Glu Leu Lys Tyr Ala Asp Ile Arg Asn Leu Gly Ala Met Ile Ala 
        35                  40                  45              


Pro Leu His Phe Leu Glu Val Lys Leu Gly Lys Arg Pro Gln Pro Val 
    50                  55                  60                  


Lys Ser Glu Leu Asp Glu Glu Glu Glu Arg Arg Lys Arg Arg Arg Glu 
65                  70                  75                  80  


Lys Asn Lys Val Ala Ala Ala Arg Cys Arg Asn Lys Lys Lys Glu Arg 
                85                  90                  95      


Thr Glu Phe Leu Gln Arg Glu Ser Glu Arg Leu Glu Leu Met Asn Ala 
            100                 105                 110         


Glu Leu Lys Thr Gln Ile Glu Glu Leu Lys Gln Glu Arg Gln Gln Leu 
        115                 120                 125             


Ile Leu Met Leu Asn Arg His Arg Pro Thr Cys Ile Val Arg Thr Asp 
    130                 135                 140                 


Ser Val Lys Thr Pro Glu Ser Glu Gly Asn Pro Leu Leu Glu Gln Leu 
145                 150                 155                 160 


Glu Lys Lys 
            


<210>  5673
<211>  2358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JMJD1C__Homo_sapiens__NP_001269877

<400>  5673

Met Gln Gly Pro Tyr Ser Leu Asn Gly Tyr Arg Val Arg Val Tyr Arg 
1               5                   10                  15      


Gln Asp Ser Ala Thr Gln Trp Phe Thr Gly Ile Ile Thr His His Asp 
            20                  25                  30          


Leu Phe Thr Arg Thr Met Ile Val Met Asn Asp Gln Val Leu Glu Pro 
        35                  40                  45              


Gln Asn Val Asp Pro Ser Met Val Gln Met Thr Phe Leu Asp Asp Val 
    50                  55                  60                  


Val His Ser Leu Leu Lys Gly Glu Asn Ile Gly Ile Thr Ser Arg Arg 
65                  70                  75                  80  


Arg Ser Arg Ala Asn Gln Asn Val Asn Ala Val His Ser His Tyr Thr 
                85                  90                  95      


Arg Ala Gln Ala Asn Ser Pro Arg Pro Ala Met Asn Ser Gln Ala Ala 
            100                 105                 110         


Val Pro Lys Gln Asn Thr His Gln Gln Gln Gln Gln Arg Ser Ile Arg 
        115                 120                 125             


Pro Asn Lys Arg Lys Gly Ser Asp Ser Ser Ile Pro Asp Glu Glu Lys 
    130                 135                 140                 


Met Lys Glu Glu Lys Tyr Asp Tyr Ile Ser Arg Gly Glu Asn Pro Lys 
145                 150                 155                 160 


Gly Lys Asn Lys His Leu Met Asn Lys Arg Arg Lys Pro Glu Glu Asp 
                165                 170                 175     


Glu Lys Lys Leu Asn Met Lys Arg Leu Arg Thr Asp Asn Val Ser Asp 
            180                 185                 190         


Phe Ser Glu Ser Ser Asp Ser Glu Asn Ser Asn Lys Arg Ile Ile Asp 
        195                 200                 205             


Asn Ser Ser Glu Gln Lys Pro Glu Asn Glu Leu Lys Asn Lys Asn Thr 
    210                 215                 220                 


Ser Lys Ile Asn Gly Glu Glu Gly Lys Pro His Asn Asn Glu Lys Ala 
225                 230                 235                 240 


Gly Glu Glu Thr Leu Lys Asn Ser Gln Pro Pro Trp Asp Gln Ile Gln 
                245                 250                 255     


Glu Asp Lys Lys His Glu Glu Ala Glu Lys Arg Lys Ser Val Asp Thr 
            260                 265                 270         


Gln Leu Gln Glu Asp Met Ile Ile His Ser Ser Glu Gln Ser Thr Val 
        275                 280                 285             


Ser Asp His Asn Ser Asn Asp Leu Leu Pro Gln Glu Cys Asn Met Asp 
    290                 295                 300                 


Lys Thr His Thr Met Glu Leu Leu Pro Lys Glu Lys Phe Val Ser Arg 
305                 310                 315                 320 


Pro Pro Thr Pro Lys Cys Val Ile Asp Ile Thr Asn Asp Thr Asn Leu 
                325                 330                 335     


Glu Lys Val Ala Gln Glu Asn Ser Ser Thr Phe Gly Leu Gln Thr Leu 
            340                 345                 350         


Gln Lys Met Asp Pro Asn Val Ser Asp Ser Lys His Ser Ile Ala Asn 
        355                 360                 365             


Ala Lys Phe Leu Glu Thr Ala Lys Lys Asp Ser Asp Gln Ser Trp Val 
    370                 375                 380                 


Ser Asp Val Val Lys Val Asp Leu Thr Gln Ser Ser Val Thr Asn Ala 
385                 390                 395                 400 


Ser Ser Gly Asn Asp His Leu Asn Met Glu Lys Glu Lys Tyr Val Ser 
                405                 410                 415     


Tyr Ile Ser Pro Leu Ser Ala Val Ser Val Met Glu Asp Lys Leu His 
            420                 425                 430         


Lys Arg Ser Pro Pro Pro Glu Thr Ile Lys Ser Lys Leu Asn Thr Ser 
        435                 440                 445             


Val Asp Thr His Lys Ile Lys Ser Ser Pro Ser Pro Glu Val Val Lys 
    450                 455                 460                 


Pro Lys Ile Thr His Ser Pro Asp Ser Val Lys Ser Lys Ala Thr Tyr 
465                 470                 475                 480 


Val Asn Ser Gln Ala Thr Gly Glu Arg Arg Leu Ala Asn Lys Ile Glu 
                485                 490                 495     


His Glu Leu Ser Arg Cys Ser Phe His Pro Ile Pro Thr Arg Ser Ser 
            500                 505                 510         


Thr Leu Glu Thr Thr Lys Ser Pro Leu Ile Ile Asp Lys Asn Glu His 
        515                 520                 525             


Phe Thr Val Tyr Arg Asp Pro Ala Leu Ile Gly Ser Glu Thr Gly Ala 
    530                 535                 540                 


Asn His Ile Ser Pro Phe Leu Ser Gln His Pro Phe Pro Leu His Ser 
545                 550                 555                 560 


Ser Ser His Arg Thr Cys Leu Asn Pro Gly Thr His His Pro Ala Leu 
                565                 570                 575     


Thr Pro Ala Pro His Leu Leu Ala Gly Ser Ser Ser Gln Thr Pro Leu 
            580                 585                 590         


Pro Thr Ile Asn Thr His Pro Leu Thr Ser Gly Pro His His Ala Val 
        595                 600                 605             


His His Pro His Leu Leu Pro Thr Val Leu Pro Gly Val Pro Thr Ala 
    610                 615                 620                 


Ser Leu Leu Gly Gly His Pro Arg Leu Glu Ser Ala His Ala Ser Ser 
625                 630                 635                 640 


Leu Ser His Leu Ala Leu Ala His Gln Gln Gln Gln Gln Leu Leu Gln 
                645                 650                 655     


His Gln Ser Pro His Leu Leu Gly Gln Ala His Pro Ser Ala Ser Tyr 
            660                 665                 670         


Asn Gln Leu Gly Leu Tyr Pro Ile Ile Trp Gln Tyr Pro Asn Gly Thr 
        675                 680                 685             


His Ala Tyr Ser Gly Leu Gly Leu Pro Ser Ser Lys Trp Val His Pro 
    690                 695                 700                 


Glu Asn Ala Val Asn Ala Glu Ala Ser Leu Arg Arg Asn Ser Pro Ser 
705                 710                 715                 720 


Pro Trp Leu His Gln Pro Thr Pro Val Thr Ser Ala Asp Gly Ile Gly 
                725                 730                 735     


Leu Leu Ser His Ile Pro Val Arg Pro Ser Ser Ala Glu Pro His Arg 
            740                 745                 750         


Pro Leu Lys Ile Thr Ala His Ser Ser Pro Pro Leu Thr Lys Thr Leu 
        755                 760                 765             


Val Asp His His Lys Glu Glu Leu Glu Arg Lys Ala Phe Met Glu Pro 
    770                 775                 780                 


Leu Arg Ser Val Ala Ser Thr Ser Ala Lys Asn Asp Leu Asp Leu Asn 
785                 790                 795                 800 


Arg Ser Gln Thr Gly Lys Asp Cys His Leu His Arg His Phe Val Asp 
                805                 810                 815     


Pro Val Leu Asn Gln Leu Gln Arg Pro Pro Gln Glu Thr Gly Glu Arg 
            820                 825                 830         


Leu Asn Lys Tyr Lys Glu Glu His Arg Arg Ile Leu Gln Glu Ser Ile 
        835                 840                 845             


Asp Val Ala Pro Phe Thr Thr Lys Ile Lys Gly Leu Glu Gly Glu Arg 
    850                 855                 860                 


Glu Asn Tyr Ser Arg Val Ala Ser Ser Ser Ser Ser Pro Lys Ser His 
865                 870                 875                 880 


Ile Ile Lys Gln Asp Met Asp Val Glu Arg Ser Val Ser Asp Leu Tyr 
                885                 890                 895     


Lys Met Lys His Ser Val Pro Gln Ser Leu Pro Gln Ser Asn Tyr Phe 
            900                 905                 910         


Thr Thr Leu Ser Asn Ser Val Val Asn Glu Pro Pro Arg Ser Tyr Pro 
        915                 920                 925             


Ser Lys Glu Val Ser Asn Ile Tyr Gly Asp Lys Gln Ser Asn Ala Leu 
    930                 935                 940                 


Ala Ala Ala Ala Ala Asn Pro Gln Thr Leu Thr Ser Phe Ile Thr Ser 
945                 950                 955                 960 


Leu Ser Lys Pro Pro Pro Leu Ile Lys His Gln Pro Glu Ser Glu Gly 
                965                 970                 975     


Leu Val Gly Lys Ile Pro Glu His Leu Pro His Gln Ile Ala Ser His 
            980                 985                 990         


Ser Val Thr Thr Phe Arg Asn Asp  Cys Arg Ser Pro Thr  His Leu Thr 
        995                 1000                 1005             


Val Ser  Ser Thr Asn Thr Leu  Arg Ser Met Pro Ala  Leu His Arg 
    1010                 1015                 1020             


Ala Pro  Val Phe His Pro Pro  Ile His His Ser Leu  Glu Arg Lys 
    1025                 1030                 1035             


Glu Gly  Ser Tyr Ser Ser Leu  Ser Pro Pro Thr Leu  Thr Pro Val 
    1040                 1045                 1050             


Met Pro  Val Asn Ala Gly Gly  Lys Val Gln Glu Ser  Gln Lys Pro 
    1055                 1060                 1065             


Pro Thr  Leu Ile Pro Glu Pro  Lys Asp Ser Gln Ala  Asn Phe Lys 
    1070                 1075                 1080             


Ser Ser  Ser Glu Gln Ser Leu  Thr Glu Met Trp Arg  Pro Asn Asn 
    1085                 1090                 1095             


Asn Leu  Ser Lys Glu Lys Thr  Glu Trp His Val Glu  Lys Ser Ser 
    1100                 1105                 1110             


Gly Lys  Leu Gln Ala Ala Met  Ala Ser Val Ile Val  Arg Pro Ser 
    1115                 1120                 1125             


Ser Ser  Thr Lys Thr Asp Ser  Met Pro Ala Met Gln  Leu Ala Ser 
    1130                 1135                 1140             


Lys Asp  Arg Val Ser Glu Arg  Ser Ser Ala Gly Ala  His Lys Thr 
    1145                 1150                 1155             


Asp Cys  Leu Lys Leu Ala Glu  Ala Gly Glu Thr Gly  Arg Ile Ile 
    1160                 1165                 1170             


Leu Pro  Asn Val Asn Ser Asp  Ser Val His Thr Lys  Ser Glu Lys 
    1175                 1180                 1185             


Asn Phe  Gln Ala Val Ser Gln  Gly Ser Val Pro Ser  Ser Val Met 
    1190                 1195                 1200             


Ser Ala  Val Asn Thr Met Cys  Asn Thr Lys Thr Asp  Val Ile Thr 
    1205                 1210                 1215             


Ser Ala  Ala Asp Thr Thr Ser  Val Ser Ser Trp Gly  Gly Ser Glu 
    1220                 1225                 1230             


Val Ile  Ser Ser Leu Ser Asn  Thr Ile Leu Ala Ser  Thr Ser Ser 
    1235                 1240                 1245             


Glu Cys  Val Ser Ser Lys Ser  Val Ser Gln Pro Val  Ala Gln Lys 
    1250                 1255                 1260             


Gln Glu  Cys Lys Val Ser Thr  Thr Ala Pro Val Thr  Leu Ala Ser 
    1265                 1270                 1275             


Ser Lys  Thr Gly Ser Val Val  Gln Pro Ser Ser Gly  Phe Ser Gly 
    1280                 1285                 1290             


Thr Thr  Asp Phe Ile His Leu  Lys Lys His Lys Ala  Ala Leu Ala 
    1295                 1300                 1305             


Ala Ala  Gln Tyr Lys Ser Ser  Asn Ala Ser Glu Thr  Glu Pro Asn 
    1310                 1315                 1320             


Ala Ile  Lys Asn Gln Thr Leu  Ser Ala Ser Leu Pro  Leu Asp Ser 
    1325                 1330                 1335             


Thr Val  Ile Cys Ser Thr Ile  Asn Lys Ala Asn Ser  Val Gly Asn 
    1340                 1345                 1350             


Gly Gln  Ala Ser Gln Thr Ser  Gln Pro Asn Tyr His  Thr Lys Leu 
    1355                 1360                 1365             


Lys Lys  Ala Trp Leu Thr Arg  His Ser Glu Glu Asp  Lys Asn Thr 
    1370                 1375                 1380             


Asn Lys  Met Glu Asn Ser Gly  Asn Ser Val Ser Glu  Ile Ile Lys 
    1385                 1390                 1395             


Pro Cys  Ser Val Asn Leu Ile  Ala Ser Thr Ser Ser  Asp Ile Gln 
    1400                 1405                 1410             


Asn Ser  Val Asp Ser Lys Ile  Ile Val Asp Lys Tyr  Val Lys Asp 
    1415                 1420                 1425             


Asp Lys  Val Asn Arg Arg Lys  Ala Lys Arg Thr Tyr  Glu Ser Gly 
    1430                 1435                 1440             


Ser Glu  Ser Gly Asp Ser Asp  Glu Ser Glu Ser Lys  Ser Glu Gln 
    1445                 1450                 1455             


Arg Thr  Lys Arg Gln Pro Lys  Pro Thr Tyr Lys Lys  Lys Gln Asn 
    1460                 1465                 1470             


Asp Leu  Gln Lys Arg Lys Gly  Glu Ile Glu Glu Asp  Leu Lys Pro 
    1475                 1480                 1485             


Asn Gly  Val Leu Ser Arg Ser  Ala Lys Glu Arg Ser  Lys Leu Lys 
    1490                 1495                 1500             


Leu Gln  Ser Asn Ser Asn Thr  Gly Ile Pro Arg Ser  Val Leu Lys 
    1505                 1510                 1515             


Asp Trp  Arg Lys Val Lys Lys  Leu Lys Gln Thr Gly  Glu Ser Phe 
    1520                 1525                 1530             


Leu Gln  Asp Asp Ser Cys Cys  Glu Ile Gly Pro Asn  Leu Gln Lys 
    1535                 1540                 1545             


Cys Arg  Glu Cys Arg Leu Ile  Arg Ser Lys Lys Gly  Glu Glu Pro 
    1550                 1555                 1560             


Ala His  Ser Pro Val Phe Cys  Arg Phe Tyr Tyr Phe  Arg Arg Leu 
    1565                 1570                 1575             


Ser Phe  Ser Lys Asn Gly Val  Val Arg Ile Asp Gly  Phe Ser Ser 
    1580                 1585                 1590             


Pro Asp  Gln Tyr Asp Asp Glu  Ala Met Ser Leu Trp  Thr His Glu 
    1595                 1600                 1605             


Asn Phe  Glu Asp Asp Glu Leu  Asp Ile Glu Thr Ser  Lys Tyr Ile 
    1610                 1615                 1620             


Leu Asp  Ile Ile Gly Asp Lys  Phe Cys Gln Leu Val  Thr Ser Glu 
    1625                 1630                 1635             


Lys Thr  Ala Leu Ser Trp Val  Lys Lys Asp Ala Lys  Ile Ala Trp 
    1640                 1645                 1650             


Lys Arg  Ala Val Arg Gly Val  Arg Glu Met Cys Asp  Ala Cys Glu 
    1655                 1660                 1665             


Ala Thr  Leu Phe Asn Ile His  Trp Val Cys Gln Lys  Cys Gly Phe 
    1670                 1675                 1680             


Val Val  Cys Leu Asp Cys Tyr  Lys Ala Lys Glu Arg  Lys Ser Ser 
    1685                 1690                 1695             


Arg Asp  Lys Glu Leu Tyr Ala  Trp Met Lys Cys Val  Lys Gly Gln 
    1700                 1705                 1710             


Pro His  Asp His Lys His Leu  Met Pro Thr Gln Ile  Ile Pro Gly 
    1715                 1720                 1725             


Ser Val  Leu Thr Asp Leu Leu  Asp Ala Met His Thr  Leu Arg Glu 
    1730                 1735                 1740             


Lys Tyr  Gly Ile Lys Ser His  Cys His Cys Thr Asn  Lys Gln Asn 
    1745                 1750                 1755             


Leu Gln  Val Gly Asn Phe Pro  Thr Met Asn Gly Val  Ser Gln Val 
    1760                 1765                 1770             


Leu Gln  Asn Val Leu Asn His  Ser Asn Lys Ile Ser  Leu Cys Met 
    1775                 1780                 1785             


Pro Glu  Ser Gln Gln Gln Asn  Thr Pro Pro Lys Ser  Glu Lys Asn 
    1790                 1795                 1800             


Gly Gly  Ser Ser Pro Glu Ser  Asp Val Gly Thr Asp  Asn Lys Leu 
    1805                 1810                 1815             


Thr Pro  Pro Glu Ser Gln Ser  Pro Leu His Trp Leu  Ala Asp Leu 
    1820                 1825                 1830             


Ala Glu  Gln Lys Ala Arg Glu  Glu Lys Lys Glu Asn  Lys Glu Leu 
    1835                 1840                 1845             


Thr Leu  Glu Asn Gln Ile Lys  Glu Glu Arg Glu Gln  Asp Asn Ser 
    1850                 1855                 1860             


Glu Ser  Pro Asn Gly Arg Thr  Ser Pro Leu Val Ser  Gln Asn Asn 
    1865                 1870                 1875             


Glu Gln  Gly Ser Thr Leu Arg  Asp Leu Leu Thr Thr  Thr Ala Gly 
    1880                 1885                 1890             


Lys Leu  Arg Val Gly Ser Thr  Asp Ala Gly Ile Ala  Phe Ala Pro 
    1895                 1900                 1905             


Val Tyr  Ser Met Gly Ala Pro  Ser Ser Lys Ser Gly  Arg Thr Met 
    1910                 1915                 1920             


Pro Asn  Ile Leu Asp Asp Ile  Ile Ala Ser Val Val  Glu Asn Lys 
    1925                 1930                 1935             


Ile Pro  Pro Ser Lys Thr Ser  Lys Ile Asn Val Lys  Pro Glu Leu 
    1940                 1945                 1950             


Lys Glu  Glu Pro Glu Glu Ser  Ile Ile Ser Ala Val  Asp Glu Asn 
    1955                 1960                 1965             


Asn Lys  Leu Tyr Ser Asp Ile  Pro His Ser Trp Ile  Cys Glu Lys 
    1970                 1975                 1980             


His Ile  Leu Trp Leu Lys Asp  Tyr Lys Asn Ser Ser  Asn Trp Lys 
    1985                 1990                 1995             


Leu Phe  Lys Glu Cys Trp Lys  Gln Gly Gln Pro Ala  Val Val Ser 
    2000                 2005                 2010             


Gly Val  His Lys Lys Met Asn  Ile Ser Leu Trp Lys  Ala Glu Ser 
    2015                 2020                 2025             


Ile Ser  Leu Asp Phe Gly Asp  His Gln Ala Asp Leu  Leu Asn Cys 
    2030                 2035                 2040             


Lys Asp  Ser Ile Ile Ser Asn  Ala Asn Val Lys Glu  Phe Trp Asp 
    2045                 2050                 2055             


Gly Phe  Glu Glu Val Ser Lys  Arg Gln Lys Asn Lys  Ser Gly Glu 
    2060                 2065                 2070             


Thr Val  Val Leu Lys Leu Lys  Asp Trp Pro Ser Gly  Glu Asp Phe 
    2075                 2080                 2085             


Lys Thr  Met Met Pro Ala Arg  Tyr Glu Asp Leu Leu  Lys Ser Leu 
    2090                 2095                 2100             


Pro Leu  Pro Glu Tyr Cys Asn  Pro Glu Gly Lys Phe  Asn Leu Ala 
    2105                 2110                 2115             


Ser His  Leu Pro Gly Phe Phe  Val Arg Pro Asp Leu  Gly Pro Arg 
    2120                 2125                 2130             


Leu Cys  Ser Ala Tyr Gly Val  Val Ala Ala Lys Asp  His Asp Ile 
    2135                 2140                 2145             


Gly Thr  Thr Asn Leu His Ile  Glu Val Ser Asp Val  Val Asn Ile 
    2150                 2155                 2160             


Leu Val  Tyr Val Gly Ile Ala  Lys Gly Asn Gly Ile  Leu Ser Lys 
    2165                 2170                 2175             


Ala Gly  Ile Leu Lys Lys Phe  Glu Glu Glu Asp Leu  Asp Asp Ile 
    2180                 2185                 2190             


Leu Arg  Lys Arg Leu Lys Asp  Ser Ser Glu Ile Pro  Gly Ala Leu 
    2195                 2200                 2205             


Trp His  Ile Tyr Ala Gly Lys  Asp Val Asp Lys Ile  Arg Glu Phe 
    2210                 2215                 2220             


Leu Gln  Lys Ile Ser Lys Glu  Gln Gly Leu Glu Val  Leu Pro Glu 
    2225                 2230                 2235             


His Asp  Pro Ile Arg Asp Gln  Ser Trp Tyr Val Asn  Lys Lys Leu 
    2240                 2245                 2250             


Arg Gln  Arg Leu Leu Glu Glu  Tyr Gly Val Arg Thr  Cys Thr Leu 
    2255                 2260                 2265             


Ile Gln  Phe Leu Gly Asp Ala  Ile Val Leu Pro Ala  Gly Ala Leu 
    2270                 2275                 2280             


His Gln  Val Gln Asn Phe His  Ser Cys Ile Gln Val  Thr Glu Asp 
    2285                 2290                 2295             


Phe Val  Ser Pro Glu His Leu  Val Glu Ser Phe His  Leu Thr Gln 
    2300                 2305                 2310             


Glu Leu  Arg Leu Leu Lys Glu  Glu Ile Asn Tyr Asp  Asp Lys Leu 
    2315                 2320                 2325             


Gln Val  Lys Asn Ile Leu Tyr  His Ala Val Lys Glu  Met Val Arg 
    2330                 2335                 2340             


Ala Leu  Lys Ile His Glu Asp  Glu Val Glu Asp Met  Glu Glu Asn 
    2345                 2350                 2355             


<210>  5674
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JMJD6__Homo_sapiens__NP_001074930

<400>  5674

Met Asn His Lys Ser Lys Lys Arg Ile Arg Glu Ala Lys Arg Ser Ala 
1               5                   10                  15      


Arg Pro Glu Leu Lys Asp Ser Leu Asp Trp Thr Arg His Asn Tyr Tyr 
            20                  25                  30          


Glu Ser Phe Ser Leu Ser Pro Ala Ala Val Ala Asp Asn Val Glu Arg 
        35                  40                  45              


Ala Asp Ala Leu Gln Leu Ser Val Glu Glu Phe Val Glu Arg Tyr Glu 
    50                  55                  60                  


Arg Pro Tyr Lys Pro Val Val Leu Leu Asn Ala Gln Glu Gly Trp Ser 
65                  70                  75                  80  


Ala Gln Glu Lys Trp Thr Leu Glu Arg Leu Lys Arg Lys Tyr Arg Asn 
                85                  90                  95      


Gln Lys Phe Lys Cys Gly Glu Asp Asn Asp Gly Tyr Ser Val Lys Met 
            100                 105                 110         


Lys Met Lys Tyr Tyr Ile Glu Tyr Met Glu Ser Thr Arg Asp Asp Ser 
        115                 120                 125             


Pro Leu Tyr Ile Phe Asp Ser Ser Tyr Gly Glu His Pro Lys Arg Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Tyr Lys Val Pro Lys Phe Phe Thr Asp Asp Leu 
145                 150                 155                 160 


Phe Gln Tyr Ala Gly Glu Lys Arg Arg Pro Pro Tyr Arg Trp Phe Val 
                165                 170                 175     


Met Gly Pro Pro Arg Ser Gly Thr Gly Ile His Ile Asp Pro Leu Gly 
            180                 185                 190         


Thr Ser Ala Trp Asn Ala Leu Val Gln Gly His Lys Arg Trp Cys Leu 
        195                 200                 205             


Phe Pro Thr Ser Thr Pro Arg Glu Leu Ile Lys Val Thr Arg Asp Glu 
    210                 215                 220                 


Gly Gly Asn Gln Gln Asp Glu Ala Ile Thr Trp Phe Asn Val Ile Tyr 
225                 230                 235                 240 


Pro Arg Thr Gln Leu Pro Thr Trp Pro Pro Glu Phe Lys Pro Leu Glu 
                245                 250                 255     


Ile Leu Gln Lys Pro Gly Glu Thr Val Phe Val Pro Gly Gly Trp Trp 
            260                 265                 270         


His Val Val Leu Asn Leu Asp Thr Thr Ile Ala Ile Thr Gln Asn Phe 
        275                 280                 285             


Ala Ser Ser Thr Asn Phe Pro Val Val Trp His Lys Thr Val Arg Gly 
    290                 295                 300                 


Arg Pro Lys Leu Ser Arg Lys Trp Tyr Arg Ile Leu Lys Gln Glu His 
305                 310                 315                 320 


Pro Glu Leu Ala Val Leu Ala Asp Ser Val Asp Leu Gln Glu Ser Thr 
                325                 330                 335     


Gly Ile Ala Ser Asp Ser Ser Ser Asp Ser Ser Ser Ser Ser Ser Ser 
            340                 345                 350         


Ser Ser Ser Asp Ser Asp Ser Glu Cys Glu Ser Gly Ser Glu Gly Asp 
        355                 360                 365             


Gly Thr Val His Arg Arg Lys Lys Arg Arg Thr Cys Ser Met Val Gly 
    370                 375                 380                 


Asn Gly Asp Thr Thr Ser Gln Asp Asp Cys Val Ser Lys Glu Arg Ser 
385                 390                 395                 400 


Ser Ser Arg Ile Arg Asp Thr Cys Gly Gly Arg Ala His Pro 
                405                 410                 


<210>  5675
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JMY__Homo_sapiens__NP_689618

<400>  5675

Met Ser Phe Ala Leu Glu Glu Thr Leu Glu Ser Asp Trp Val Ala Val 
1               5                   10                  15      


Arg Pro His Val Phe Asp Glu Arg Glu Lys His Lys Phe Val Phe Ile 
            20                  25                  30          


Val Ala Trp Asn Glu Ile Glu Gly Lys Phe Ala Ile Thr Cys His Asn 
        35                  40                  45              


Arg Thr Ala Gln Arg Gln Arg Ser Gly Ser Arg Glu Gln Ala Gly Ala 
    50                  55                  60                  


Arg Gly Gly Ala Glu Ala Gly Gly Ala Ala Ser Asp Gly Ser Arg Gly 
65                  70                  75                  80  


Pro Gly Ser Pro Ala Gly Arg Gly Arg Pro Glu Ala Thr Ala Ser Ala 
                85                  90                  95      


Thr Leu Val Arg Ser Pro Gly Pro Arg Arg Ser Ser Ala Trp Ala Glu 
            100                 105                 110         


Gly Gly Ser Pro Arg Ser Thr Arg Ser Leu Leu Gly Asp Pro Arg Leu 
        115                 120                 125             


Arg Ser Pro Gly Ser Lys Gly Ala Glu Ser Arg Leu Arg Ser Pro Val 
    130                 135                 140                 


Arg Ala Lys Pro Ile Pro Gly Gln Lys Thr Ser Glu Ala Asp Asp Ala 
145                 150                 155                 160 


Ala Gly Ala Ala Ala Ala Ala Ala Arg Pro Ala Pro Arg Glu Ala Gln 
                165                 170                 175     


Val Ser Ser Val Arg Ile Val Ser Ala Ser Gly Thr Val Ser Glu Glu 
            180                 185                 190         


Ile Glu Val Leu Glu Met Val Lys Glu Asp Glu Ala Pro Leu Ala Leu 
        195                 200                 205             


Ser Asp Ala Glu Gln Pro Pro Pro Ala Thr Glu Leu Glu Ser Pro Ala 
    210                 215                 220                 


Glu Glu Cys Ser Trp Ala Gly Leu Phe Ser Phe Gln Asp Leu Arg Ala 
225                 230                 235                 240 


Val His Gln Gln Leu Cys Ser Val Asn Ser Gln Leu Glu Pro Cys Leu 
                245                 250                 255     


Pro Val Phe Pro Glu Glu Pro Ser Gly Met Trp Thr Val Leu Phe Gly 
            260                 265                 270         


Gly Ala Pro Glu Met Thr Glu Gln Glu Ile Asp Thr Leu Cys Tyr Gln 
        275                 280                 285             


Leu Gln Val Tyr Leu Gly His Gly Leu Asp Thr Cys Gly Trp Lys Ile 
    290                 295                 300                 


Leu Ser Gln Val Leu Phe Thr Glu Thr Asp Asp Pro Glu Glu Tyr Tyr 
305                 310                 315                 320 


Glu Ser Leu Ser Glu Leu Arg Gln Lys Gly Tyr Glu Glu Val Leu Gln 
                325                 330                 335     


Arg Ala Arg Lys Arg Ile Gln Glu Leu Leu Asp Lys His Lys Asn Thr 
            340                 345                 350         


Glu Ser Met Val Glu Leu Leu Asp Leu Tyr Gln Met Glu Asp Glu Ala 
        355                 360                 365             


Tyr Ser Ser Leu Ala Glu Ala Thr Thr Glu Leu Tyr Gln Tyr Leu Leu 
    370                 375                 380                 


Gln Pro Phe Arg Asp Met Arg Glu Leu Ala Met Leu Arg Arg Gln Gln 
385                 390                 395                 400 


Ile Lys Ile Ser Met Glu Asn Asp Tyr Leu Gly Pro Arg Arg Ile Glu 
                405                 410                 415     


Ser Leu Gln Lys Glu Asp Ala Asp Trp Gln Arg Lys Ala His Met Ala 
            420                 425                 430         


Val Leu Ser Ile Gln Asp Leu Thr Val Lys Tyr Phe Glu Ile Thr Ala 
        435                 440                 445             


Lys Ala Gln Lys Ala Val Tyr Asp Arg Met Arg Ala Asp Gln Lys Lys 
    450                 455                 460                 


Phe Gly Lys Ala Ser Trp Ala Ala Ala Ala Glu Arg Met Glu Lys Leu 
465                 470                 475                 480 


Gln Tyr Ala Val Ser Lys Glu Thr Leu Gln Met Met Arg Ala Lys Glu 
                485                 490                 495     


Ile Cys Leu Glu Gln Arg Lys His Ala Leu Lys Glu Glu Met Gln Ser 
            500                 505                 510         


Leu Arg Gly Gly Thr Glu Ala Ile Ala Arg Leu Asp Gln Leu Glu Ala 
        515                 520                 525             


Asp Tyr Tyr Asp Leu Gln Leu Gln Leu Tyr Glu Val Gln Phe Glu Ile 
    530                 535                 540                 


Leu Lys Cys Glu Glu Leu Leu Leu Thr Ala Gln Leu Glu Ser Ile Lys 
545                 550                 555                 560 


Arg Leu Ile Ser Glu Lys Arg Asp Glu Val Val Tyr Tyr Asp Thr Tyr 
                565                 570                 575     


Glu Ser Met Glu Ala Met Leu Glu Lys Glu Glu Met Ala Ala Ser Ala 
            580                 585                 590         


Tyr Leu Gln Arg Glu Glu Leu Gln Lys Leu Gln Gln Lys Ala Arg Gln 
        595                 600                 605             


Leu Glu Ala Arg Arg Gly Arg Val Ser Ala Lys Lys Ser Tyr Leu Arg 
    610                 615                 620                 


Asn Lys Lys Glu Ile Cys Ile Ala Lys His Asn Glu Lys Ile Gln Gln 
625                 630                 635                 640 


Arg Thr Arg Ile Glu Asp Glu Tyr Arg Thr His His Thr Val Gln Leu 
                645                 650                 655     


Lys Arg Glu Lys Leu His Asp Glu Glu Glu Arg Lys Ser Ala Trp Val 
            660                 665                 670         


Ser Gln Glu Arg Gln Arg Thr Leu Asp Arg Leu Arg Thr Phe Lys Gln 
        675                 680                 685             


Arg Tyr Pro Gly Gln Val Ile Leu Lys Ser Thr Arg Leu Arg Leu Ala 
    690                 695                 700                 


His Ala Arg Arg Lys Gly Ala Ala Ser Pro Val Leu Gln Glu Asp His 
705                 710                 715                 720 


Cys Asp Ser Leu Pro Ser Val Leu Gln Val Glu Glu Lys Thr Glu Glu 
                725                 730                 735     


Val Gly Glu Gly Arg Val Lys Arg Gly Pro Ser Gln Thr Thr Glu Pro 
            740                 745                 750         


Gln Ser Leu Val Gln Leu Glu Asp Thr Ser Leu Thr Gln Leu Glu Ala 
        755                 760                 765             


Thr Ser Leu Pro Leu Ser Gly Val Thr Ser Glu Leu Pro Pro Thr Ile 
    770                 775                 780                 


Ser Leu Pro Leu Leu Asn Asn Asn Leu Glu Pro Cys Ser Val Thr Ile 
785                 790                 795                 800 


Asn Pro Leu Pro Ser Pro Leu Pro Pro Thr Pro Pro Pro Pro Pro Pro 
                805                 810                 815     


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Val Ala Lys Asp Ser 
            820                 825                 830         


Gly Pro Glu Thr Leu Glu Lys Asp Leu Pro Arg Lys Glu Gly Asn Glu 
        835                 840                 845             


Lys Arg Ile Pro Lys Ser Ala Ser Ala Pro Ser Ala His Leu Phe Asp 
    850                 855                 860                 


Ser Ser Gln Leu Val Ser Ala Arg Lys Lys Leu Arg Lys Thr Ala Glu 
865                 870                 875                 880 


Gly Leu Gln Arg Arg Arg Val Ser Ser Pro Met Asp Glu Val Leu Ala 
                885                 890                 895     


Ser Leu Lys Arg Gly Ser Phe His Leu Lys Lys Val Glu Gln Arg Thr 
            900                 905                 910         


Leu Pro Pro Phe Pro Asp Glu Asp Asp Ser Asn Asn Ile Leu Ala Gln 
        915                 920                 925             


Ile Arg Lys Gly Val Lys Leu Lys Lys Val Gln Lys Asp Val Leu Arg 
    930                 935                 940                 


Glu Ser Phe Thr Leu Leu Pro Asp Thr Asp Pro Leu Thr Arg Ser Ile 
945                 950                 955                 960 


His Glu Ala Leu Arg Arg Ile Lys Glu Ala Ser Pro Glu Ser Glu Asp 
                965                 970                 975     


Glu Glu Glu Ala Leu Pro Cys Thr Asp Trp Glu Asn 
            980                 985             


<210>  5676
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JPH2__Homo_sapiens__NP_787109

<400>  5676

Met Ser Gly Gly Arg Phe Asp Phe Asp Asp Gly Gly Ala Tyr Cys Gly 
1               5                   10                  15      


Gly Trp Glu Gly Gly Lys Ala His Gly His Gly Leu Cys Thr Gly Pro 
            20                  25                  30          


Lys Gly Gln Gly Glu Tyr Ser Gly Ser Trp Asn Phe Gly Phe Glu Val 
        35                  40                  45              


Ala Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Phe Glu Gly Tyr Trp 
    50                  55                  60                  


Ser Gln Gly Lys Arg His Gly Leu Gly Ile Glu Thr Lys Gly Arg Trp 
65                  70                  75                  80  


Leu Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg Tyr Gly Ile 
                85                  90                  95      


Arg Gln Ser Ser Ser Ser Gly Ala Lys Tyr Glu Gly Thr Trp Asn Asn 
            100                 105                 110         


Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ala Asp Gly Gly Met 
        115                 120                 125             


Cys 
    


<210>  5677
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JPH3__Homo_sapiens__NP_001258533

<400>  5677

Met Ser Ser Gly Gly Arg Phe Asn Phe Asp Asp Gly Gly Ser Tyr Cys 
1               5                   10                  15      


Gly Gly Trp Glu Asp Gly Lys Ala His Gly His Gly Val Cys Thr Gly 
            20                  25                  30          


Pro Lys Gly Gln Gly Glu Tyr Thr Gly Ser Trp Ser His Gly Phe Glu 
        35                  40                  45              


Val Leu Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln Gly Thr 
    50                  55                  60                  


Trp Ala Gln Gly Lys Arg His Gly Ile Gly Leu Glu Ser Lys Gly Lys 
65                  70                  75                  80  


Trp Val Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg Tyr Gly 
                85                  90                  95      


Val Arg Glu Cys Ala Gly Asn Gly Ala Lys Tyr Glu Gly Thr Trp Ser 
            100                 105                 110         


Asn Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ser Asp Gly Asp 
        115                 120                 125             


Ala Thr Ala Phe Gly Ala Glu Pro Gly Pro Glu Ala Arg Glu Leu Pro 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Arg Trp 
145                 150                 155                 160 


Phe Leu Cys Arg Glu Pro Trp Pro Ala Leu Gln Leu Pro Ala Cys Leu 
                165                 170                 175     


Asp Ser Pro Ile Ser Thr Pro Gln Cys Thr 
            180                 185     


<210>  5678
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JPH4__Homo_sapiens__NP_115828

<400>  5678

Met Ser Pro Gly Gly Lys Phe Asp Phe Asp Asp Gly Gly Cys Tyr Val 
1               5                   10                  15      


Gly Gly Trp Glu Ala Gly Arg Ala His Gly Tyr Gly Val Cys Thr Gly 
            20                  25                  30          


Pro Gly Ala Gln Gly Glu Tyr Ser Gly Cys Trp Ala His Gly Phe Glu 
        35                  40                  45              


Ser Leu Gly Val Phe Thr Gly Pro Gly Gly His Ser Tyr Gln Gly His 
    50                  55                  60                  


Trp Gln Gln Gly Lys Arg Glu Gly Leu Gly Val Glu Arg Lys Ser Arg 
65                  70                  75                  80  


Trp Thr Tyr Arg Gly Glu Trp Leu Gly Gly Leu Lys Gly Arg Ser Gly 
                85                  90                  95      


Val Trp Glu Ser Val Ser Gly Leu Arg Tyr Ala Gly Leu Trp Lys Asp 
            100                 105                 110         


Gly Phe Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ser Asp Gly Gly Thr 
        115                 120                 125             


Tyr Gln Gly Gln Trp Gln Ala Gly Lys Arg His Gly Tyr Gly Val Arg 
    130                 135                 140                 


Gln Ser Val Pro Tyr His Gln Ala Ala Leu Leu Arg Ser Pro Arg Arg 
145                 150                 155                 160 


Thr Ser Leu Asp Ser Gly His Ser Asp Pro Pro Thr Pro Pro Pro Pro 
                165                 170                 175     


Leu Pro Leu Pro Gly Asp Glu Gly Gly Ser Pro Ala Ser Gly Ser Arg 
            180                 185                 190         


Gly Gly Phe Val Leu Ala Gly Pro Gly Asp Ala Asp Gly Ala Ser Ser 
        195                 200                 205             


Arg Lys Arg Thr Pro Ala Ala Gly Gly Phe Phe Arg Arg Ser Leu Leu 
    210                 215                 220                 


Leu Ser Gly Leu Arg Ala Gly Gly Arg Arg Ser Ser Leu Gly Ser Lys 
225                 230                 235                 240 


Arg Gly Ser Leu Arg Ser Glu Val Ser Ser Glu Val Gly Ser Thr Gly 
                245                 250                 255     


Pro Pro Gly Ser Glu Ala Ser Gly Pro Pro Ala Ala Ala Pro Pro Ala 
            260                 265                 270         


Leu Ile Glu Gly Ser Ala Thr Glu Val Tyr Ala Gly Glu Trp Arg Ala 
        275                 280                 285             


Asp Arg Arg Ser Gly Phe Gly Val Ser Gln Arg Ser Asn Gly Leu Arg 
    290                 295                 300                 


Tyr Glu Gly Glu Trp Leu Gly Asn Arg Arg His Gly Tyr Gly Arg Thr 
305                 310                 315                 320 


Thr Arg Pro Asp Gly Ser Arg Glu Glu Gly Lys Tyr Lys Arg Asn Arg 
                325                 330                 335     


Leu Val His Gly Gly Arg Val Arg Ser Leu Leu Pro Leu Ala Leu Arg 
            340                 345                 350         


Arg Gly Lys Val Lys Glu Lys Val Asp Arg Ala Val Glu Gly Ala Arg 
        355                 360                 365             


Arg Ala Val Ser Ala Ala Arg Gln Arg Gln Glu Ile Ala Ala Ala Arg 
    370                 375                 380                 


Ala Ala Asp Ala Leu Leu Lys Ala Val Ala Ala Ser Ser Val Ala Glu 
385                 390                 395                 400 


Lys Ala Val Glu Ala Ala Arg Met Ala Lys Leu Ile Ala Gln Asp Leu 
                405                 410                 415     


Gln Pro Met Leu Glu Ala Pro Gly Arg Arg Pro Arg Gln Asp Ser Glu 
            420                 425                 430         


Gly Ser Asp Thr Glu Pro Leu Asp Glu Asp Ser Pro Gly Val Tyr Glu 
        435                 440                 445             


Asn Gly Leu Thr Pro Ser Glu Gly Ser Pro Glu Leu Pro Ser Ser Pro 
    450                 455                 460                 


Ala Ser Ser Arg Gln Pro Trp Arg Pro Pro Ala Cys Arg Ser Pro Leu 
465                 470                 475                 480 


Pro Pro Gly Gly Asp Gln Gly Pro Phe Ser Ser Pro Lys Ala Trp Pro 
                485                 490                 495     


Glu Glu Trp Gly Gly Ala Gly Ala Gln Ala Glu Glu Leu Ala Gly Tyr 
            500                 505                 510         


Glu Ala Glu Asp Glu Ala Gly Met Gln Gly Pro Gly Pro Arg Asp Gly 
        515                 520                 525             


Ser Pro Leu Leu Gly Gly Cys Ser Asp Ser Ser Gly Ser Leu Arg Glu 
    530                 535                 540                 


Glu Glu Gly Glu Asp Glu Glu Pro Leu Pro Pro Leu Arg Ala Pro Ala 
545                 550                 555                 560 


Gly Thr Glu Pro Glu Pro Ile Ala Met Leu Val Leu Arg Gly Ser Ser 
                565                 570                 575     


Ser Arg Gly Pro Asp Ala Gly Cys Leu Thr Glu Glu Leu Gly Glu Pro 
            580                 585                 590         


Ala Ala Thr Glu Arg Pro Ala Gln Pro Gly Ala Ala Asn Pro Leu Val 
        595                 600                 605             


Val Gly Ala Val Ala Leu Leu Asp Leu Ser Leu Ala Phe Leu Phe Ser 
    610                 615                 620                 


Gln Leu Leu Thr 
625             


<210>  5679
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JRK__Homo_sapiens__NP_001070995

<400>  5679

Met Ala Ser Lys Pro Ala Ala Gly Lys Ser Arg Gly Glu Lys Arg Lys 
1               5                   10                  15      


Arg Val Val Leu Thr Leu Lys Glu Lys Ile Asp Ile Cys Thr Arg Leu 
            20                  25                  30          


Glu Lys Gly Glu Ser Arg Lys Ala Leu Met Gln Glu Tyr Asn Val Gly 
        35                  40                  45              


Met Ser Thr Leu Tyr Asp Ile Arg Ala His Lys Ala Gln Leu Leu Arg 
    50                  55                  60                  


Phe Phe Ala Ser Ser Asp Ser Asn Lys Ala Leu Glu Gln Arg Arg Thr 
65                  70                  75                  80  


Leu His Thr Pro Lys Leu Glu His Leu Asp Arg Val Leu Tyr Glu Trp 
                85                  90                  95      


Phe Leu Gly Lys Arg Ser Glu Gly Val Pro Val Ser Gly Pro Met Leu 
            100                 105                 110         


Ile Glu Lys Ala Lys Asp Phe Tyr Glu Gln Met Gln Leu Thr Glu Pro 
        115                 120                 125             


Cys Val Phe Ser Gly Gly Trp Leu Trp Arg Phe Lys Ala Arg His Gly 
    130                 135                 140                 


Ile Lys Lys Leu Asp Ala Ser Ser Glu Lys Gln Ser Ala Asp His Gln 
145                 150                 155                 160 


Ala Ala Glu Gln Phe Cys Ala Phe Phe Arg Ser Leu Ala Ala Glu His 
                165                 170                 175     


Gly Leu Ser Ala Glu Gln Val Tyr Asn Ala Asp Glu Thr Gly Leu Phe 
            180                 185                 190         


Trp Arg Cys Leu Pro Asn Pro Thr Pro Glu Gly Gly Ala Val Pro Gly 
        195                 200                 205             


Pro Lys Gln Gly Lys Asp Arg Leu Thr Val Leu Met Cys Ala Asn Ala 
    210                 215                 220                 


Thr Gly Ser His Arg Leu Lys Pro Leu Ala Ile Gly Lys Cys Ser Gly 
225                 230                 235                 240 


Pro Arg Ala Phe Lys Gly Ile Gln His Leu Pro Val Ala Tyr Lys Ala 
                245                 250                 255     


Gln Gly Asn Ala Trp Val Asp Lys Glu Ile Phe Ser Asp Trp Phe His 
            260                 265                 270         


His Ile Phe Val Pro Ser Val Arg Glu His Phe Arg Thr Ile Gly Leu 
        275                 280                 285             


Pro Glu Asp Ser Lys Ala Val Leu Leu Leu Asp Ser Ser Arg Ala His 
    290                 295                 300                 


Pro Gln Glu Ala Glu Leu Val Ser Ser Asn Val Phe Thr Ile Phe Leu 
305                 310                 315                 320 


Pro Ala Ser Val Ala Ser Leu Val Gln Pro Met Glu Gln Gly Ile Arg 
                325                 330                 335     


Arg Asp Phe Met Arg Asn Phe Ile Asn Pro Pro Val Pro Leu Gln Gly 
            340                 345                 350         


Pro His Ala Arg Tyr Asn Met Asn Asp Ala Ile Phe Ser Val Ala Cys 
        355                 360                 365             


Ala Trp Asn Ala Val Pro Ser His Val Phe Arg Arg Ala Trp Arg Lys 
    370                 375                 380                 


Leu Trp Pro Ser Val Ala Phe Ala Glu Gly Ser Ser Ser Glu Glu Glu 
385                 390                 395                 400 


Leu Glu Ala Glu Cys Phe Pro Val Lys Pro His Asn Lys Ser Phe Ala 
                405                 410                 415     


His Ile Leu Glu Leu Val Lys Glu Gly Ser Ser Cys Pro Gly Gln Leu 
            420                 425                 430         


Arg Gln Arg Gln Ala Ala Ser Trp Gly Val Ala Gly Arg Glu Ala Glu 
        435                 440                 445             


Gly Gly Arg Pro Pro Ala Ala Thr Ser Pro Ala Glu Val Val Trp Ser 
    450                 455                 460                 


Ser Glu Lys Thr Pro Lys Ala Asp Gln Asp Gly Arg Gly Asp Pro Gly 
465                 470                 475                 480 


Glu Gly Glu Glu Val Ala Trp Glu Gln Ala Ala Val Ala Phe Asp Ala 
                485                 490                 495     


Val Leu Arg Phe Ala Glu Arg Gln Pro Cys Phe Ser Ala Gln Glu Val 
            500                 505                 510         


Gly Gln Leu Arg Ala Leu Arg Ala Val Phe Arg Ser Gln Gln Gln Glu 
        515                 520                 525             


Thr Val Gly Leu Glu Asp Val Val Val Thr Ser Pro Glu Glu Leu Ala 
    530                 535                 540                 


Ile Pro Lys Cys Cys Leu Glu Ala Ser Thr Glu Thr 
545                 550                 555     


<210>  5680
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JSRP1__Homo_sapiens__NP_653217

<400>  5680

Met Ser Met Thr Thr Arg Ala Trp Glu Glu Leu Asp Gly Gly Leu Gly 
1               5                   10                  15      


Ser Cys Gln Ala Leu Glu Asp His Ser Ala Leu Ala Glu Thr Gln Glu 
            20                  25                  30          


Asp Arg Ala Ser Ala Thr Pro Arg Leu Ala Asp Ser Gly Ser Val Pro 
        35                  40                  45              


His Asp Ser Gln Val Ala Glu Gly Pro Ser Val Asp Thr Arg Pro Lys 
    50                  55                  60                  


Lys Met Glu Lys Glu Pro Ala Ala Arg Gly Thr Pro Gly Thr Gly Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Gly Ala Ser Pro Arg Ser Val Pro Ala Arg Lys 
                85                  90                  95      


Lys Ala Gln Thr Ala Pro Pro Leu Gln Pro Pro Pro Pro Pro Pro Ala 
            100                 105                 110         


Leu Ser Glu Glu Leu Pro Trp Gly Asp Leu Ser Leu Asn Lys Cys Leu 
        115                 120                 125             


Val Leu Ala Ser Leu Val Ala Leu Leu Gly Ser Ala Phe Gln Leu Cys 
    130                 135                 140                 


Arg Asp Ala Val Pro Gly Glu Ala Ala Leu Gln Ala Arg Val Pro Glu 
145                 150                 155                 160 


Pro Trp Val Pro Pro Ser Ser Ala Pro Arg Glu Pro Ser Ser Pro Leu 
                165                 170                 175     


Pro Lys Phe Glu Ala Gln Ala Pro Pro Ser Ala Pro Pro Ala Pro Arg 
            180                 185                 190         


Ala Glu Ala Glu Val Arg Pro Lys Ile Pro Gly Ser Arg Glu Ala Ala 
        195                 200                 205             


Glu Asn Asp Glu Glu Glu Pro Gly Glu Ala Thr Gly Glu Ala Val Arg 
    210                 215                 220                 


Glu Asp Arg Val Thr Leu Ala Asp Arg Gly Pro Lys Glu Arg Pro Arg 
225                 230                 235                 240 


Arg Glu Gly Lys Pro Arg Lys Glu Lys Pro Arg Lys Glu Glu Arg Pro 
                245                 250                 255     


Lys Lys Glu Arg Pro Arg Lys Glu Glu Arg Pro Arg Ala Ala Arg Glu 
            260                 265                 270         


Pro Arg Glu Ala Leu Pro Gln Arg Trp Glu Ser Arg Glu Gly Gly His 
        275                 280                 285             


Arg Pro Trp Ala Arg Asp Ser Arg Asp Ala Glu Pro Arg Lys Lys Gln 
    290                 295                 300                 


Ala Trp Val Ser Pro Arg Arg Pro Asp Glu Glu Gln Arg Pro Gly Ser 
305                 310                 315                 320 


Arg Gln Lys Leu Arg Ala Gly Lys Gly Arg Asp 
                325                 330     


<210>  5681
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JTB__Homo_sapiens__NP_006685

<400>  5681

Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     


<210>  5682
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JUNB__Homo_sapiens__NP_002220

<400>  5682

Met Cys Thr Lys Met Glu Gln Pro Phe Tyr His Asp Asp Ser Tyr Thr 
1               5                   10                  15      


Ala Thr Gly Tyr Gly Arg Ala Pro Gly Gly Leu Ser Leu His Asp Tyr 
            20                  25                  30          


Lys Leu Leu Lys Pro Ser Leu Ala Val Asn Leu Ala Asp Pro Tyr Arg 
        35                  40                  45              


Ser Leu Lys Ala Pro Gly Ala Arg Gly Pro Gly Pro Glu Gly Gly Gly 
    50                  55                  60                  


Gly Gly Ser Tyr Phe Ser Gly Gln Gly Ser Asp Thr Gly Ala Ser Leu 
65                  70                  75                  80  


Lys Leu Ala Ser Ser Glu Leu Glu Arg Leu Ile Val Pro Asn Ser Asn 
                85                  90                  95      


Gly Val Ile Thr Thr Thr Pro Thr Pro Pro Gly Gln Tyr Phe Tyr Pro 
            100                 105                 110         


Arg Gly Gly Gly Ser Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Val 
        115                 120                 125             


Thr Glu Glu Gln Glu Gly Phe Ala Asp Gly Phe Val Lys Ala Leu Asp 
    130                 135                 140                 


Asp Leu His Lys Met Asn His Val Thr Pro Pro Asn Val Ser Leu Gly 
145                 150                 155                 160 


Ala Thr Gly Gly Pro Pro Ala Gly Pro Gly Gly Val Tyr Ala Gly Pro 
                165                 170                 175     


Glu Pro Pro Pro Val Tyr Thr Asn Leu Ser Ser Tyr Ser Pro Ala Ser 
            180                 185                 190         


Ala Ser Ser Gly Gly Ala Gly Ala Ala Val Gly Thr Gly Ser Ser Tyr 
        195                 200                 205             


Pro Thr Thr Thr Ile Ser Tyr Leu Pro His Ala Pro Pro Phe Ala Gly 
    210                 215                 220                 


Gly His Pro Ala Gln Leu Gly Leu Gly Arg Gly Ala Ser Thr Phe Lys 
225                 230                 235                 240 


Glu Glu Pro Gln Thr Val Pro Glu Ala Arg Ser Arg Asp Ala Thr Pro 
                245                 250                 255     


Pro Val Ser Pro Ile Asn Met Glu Asp Gln Glu Arg Ile Lys Val Glu 
            260                 265                 270         


Arg Lys Arg Leu Arg Asn Arg Leu Ala Ala Thr Lys Cys Arg Lys Arg 
        275                 280                 285             


Lys Leu Glu Arg Ile Ala Arg Leu Glu Asp Lys Val Lys Thr Leu Lys 
    290                 295                 300                 


Ala Glu Asn Ala Gly Leu Ser Ser Thr Ala Gly Leu Leu Arg Glu Gln 
305                 310                 315                 320 


Val Ala Gln Leu Lys Gln Lys Val Met Thr His Val Ser Asn Gly Cys 
                325                 330                 335     


Gln Leu Leu Leu Gly Val Lys Gly His Ala Phe 
            340                 345         


<210>  5683
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JUND__Homo_sapiens__NP_005345

<400>  5683

Met Glu Thr Pro Phe Tyr Gly Asp Glu Ala Leu Ser Gly Leu Gly Gly 
1               5                   10                  15      


Gly Ala Ser Gly Ser Gly Gly Ser Phe Ala Ser Pro Gly Arg Leu Phe 
            20                  25                  30          


Pro Gly Ala Pro Pro Thr Ala Ala Ala Gly Ser Met Met Lys Lys Asp 
        35                  40                  45              


Ala Leu Thr Leu Ser Leu Ser Glu Gln Val Ala Ala Ala Leu Lys Pro 
    50                  55                  60                  


Ala Ala Ala Pro Pro Pro Thr Pro Leu Arg Ala Asp Gly Ala Pro Ser 
65                  70                  75                  80  


Ala Ala Pro Pro Asp Gly Leu Leu Ala Ser Pro Asp Leu Gly Leu Leu 
                85                  90                  95      


Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile Ile Gln Ser Asn Gly 
            100                 105                 110         


Leu Val Thr Thr Thr Pro Thr Ser Ser Gln Phe Leu Tyr Pro Lys Val 
        115                 120                 125             


Ala Ala Ser Glu Glu Gln Glu Phe Ala Glu Gly Phe Val Lys Ala Leu 
    130                 135                 140                 


Glu Asp Leu His Lys Gln Asn Gln Leu Gly Ala Gly Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Ala Ala Gly Gly Pro Ser Gly Thr Ala Thr Gly Ser 
                165                 170                 175     


Ala Pro Pro Gly Glu Leu Ala Pro Ala Ala Ala Ala Pro Glu Ala Pro 
            180                 185                 190         


Val Tyr Ala Asn Leu Ser Ser Tyr Ala Gly Gly Ala Gly Gly Ala Gly 
        195                 200                 205             


Gly Ala Ala Thr Val Ala Phe Ala Ala Glu Pro Val Pro Phe Pro Pro 
    210                 215                 220                 


Pro Pro Pro Pro Gly Ala Leu Gly Pro Pro Arg Leu Ala Ala Leu Lys 
225                 230                 235                 240 


Asp Glu Pro Gln Thr Val Pro Asp Val Pro Ser Phe Gly Glu Ser Pro 
                245                 250                 255     


Pro Leu Ser Pro Ile Asp Met Asp Thr Gln Glu Arg Ile Lys Ala Glu 
            260                 265                 270         


Arg Lys Arg Leu Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
        275                 280                 285             


Lys Leu Glu Arg Ile Ser Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
    290                 295                 300                 


Ser Gln Asn Thr Glu Leu Ala Ser Thr Ala Ser Leu Leu Arg Glu Gln 
305                 310                 315                 320 


Val Ala Gln Leu Lys Gln Lys Val Leu Ser His Val Asn Ser Gly Cys 
                325                 330                 335     


Gln Leu Leu Pro Gln His Gln Val Pro Ala Tyr 
            340                 345         


<210>  5684
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JUP__Homo_sapiens__XP_006721941

<400>  5684

Met Glu Val Met Asn Leu Met Glu Gln Pro Ile Lys Val Thr Glu Trp 
1               5                   10                  15      


Gln Gln Thr Tyr Thr Tyr Asp Ser Gly Ile His Ser Gly Ala Asn Thr 
            20                  25                  30          


Cys Val Pro Ser Val Ser Ser Lys Gly Ile Met Glu Glu Asp Glu Ala 
        35                  40                  45              


Cys Gly Arg Gln Tyr Thr Leu Lys Lys Thr Thr Thr Tyr Thr Gln Gly 
    50                  55                  60                  


Val Pro Pro Ser Gln Gly Asp Leu Glu Tyr Gln Met Ser Thr Thr Ala 
65                  70                  75                  80  


Arg Ala Lys Arg Val Arg Glu Ala Met Cys Pro Gly Val Ser Gly Glu 
                85                  90                  95      


Asp Ser Ser Leu Leu Leu Ala Thr Gln Val Glu Gly Gln Ala Thr Asn 
            100                 105                 110         


Leu Gln Arg Leu Ala Glu Pro Ser Gln Leu Leu Lys Ser Ala Ile Val 
        115                 120                 125             


His Leu Ile Asn Tyr Gln Asp Asp Ala Glu Leu Ala Thr Arg Ala Leu 
    130                 135                 140                 


Pro Glu Leu Thr Lys Leu Leu Asn Asp Glu Asp Pro Val Val Val Thr 
145                 150                 155                 160 


Lys Ala Ala Met Ile Val Asn Gln Leu Ser Lys Lys Glu Ala Ser Arg 
                165                 170                 175     


Arg Ala Leu Met Gly Ser Pro Gln Leu Val Ala Ala Val Val Arg Thr 
            180                 185                 190         


Met Gln Asn Thr Ser Asp Leu Asp Thr Ala Arg Cys Thr Thr Ser Ile 
        195                 200                 205             


Leu His Asn Leu Ser His His Arg Glu Gly Leu Leu Ala Ile Phe Lys 
    210                 215                 220                 


Ser Gly Gly Ile Pro Ala Leu Val Arg Met Leu Ser Ser Pro Val Glu 
225                 230                 235                 240 


Ser Val Leu Phe Tyr Ala Ile Thr Thr Leu His Asn Leu Leu Leu Tyr 
                245                 250                 255     


Gln Glu Gly Ala Lys Met Ala Val Arg Leu Ala Asp Gly Leu Gln Lys 
            260                 265                 270         


Met Val Pro Leu Leu Asn Lys Asn Asn Pro Lys Phe Leu Ala Ile Thr 
        275                 280                 285             


Thr Asp Cys Leu Gln Leu Leu Ala Tyr Gly Asn Gln Glu Ser Lys Leu 
    290                 295                 300                 


Ile Ile Leu Ala Asn Gly Gly Pro Gln Ala Leu Val Gln Ile Met Arg 
305                 310                 315                 320 


Asn Tyr Ser Tyr Glu Lys Leu Leu Trp Thr Thr Ser Arg Val Leu Lys 
                325                 330                 335     


Val Leu Ser Val Cys Pro Ser Asn Lys Pro Ala Ile Val Glu Ala Gly 
            340                 345                 350         


Gly Met Gln Ala Leu Gly Lys His Leu Thr Ser Asn Ser Pro Arg Leu 
        355                 360                 365             


Val Gln Asn Cys Leu Trp Thr Leu Arg Asn Leu Ser Asp Val Ala Thr 
    370                 375                 380                 


Lys Gln Glu Gly Leu Glu Ser Val Leu Lys Ile Leu Val Asn Gln Leu 
385                 390                 395                 400 


Ser Val Asp Asp Val Asn Val Leu Thr Cys Ala Thr Gly Thr Leu Ser 
                405                 410                 415     


Asn Leu Thr Cys Asn Asn Ser Lys Asn Lys Thr Leu Val Thr Gln Asn 
            420                 425                 430         


Ser Gly Val Glu Ala Leu Ile His Ala Ile Leu Arg Ala Gly Asp Lys 
        435                 440                 445             


Asp Asp Ile Thr Glu Pro Ala Val Cys Ala Leu Arg His Leu Thr Ser 
    450                 455                 460                 


Arg His Pro Glu Ala Glu Met Ala Gln Asn Ser Val Arg Leu Asn Tyr 
465                 470                 475                 480 


Gly Ile Pro Ala Ile Val Lys Leu Leu Asn Gln Pro Asn Gln Trp Pro 
                485                 490                 495     


Leu Val Lys Ala Thr Ile Gly Leu Ile Arg Asn Leu Ala Leu Cys Pro 
            500                 505                 510         


Ala Asn His Ala Pro Leu Gln Glu Ala Ala Val Ile Pro Arg Leu Val 
        515                 520                 525             


Gln Leu Leu Val Lys Ala His Gln Asp Ala Gln Arg His Val Ala Ala 
    530                 535                 540                 


Gly Thr Gln Gln Pro Tyr Thr Asp Gly Val Arg Met Glu Glu Ile Val 
545                 550                 555                 560 


Glu Gly Cys Thr Gly Ala Leu His Ile Leu Ala Arg Asp Pro Met Asn 
                565                 570                 575     


Arg Met Glu Ile Phe Arg Leu Asn Thr Ile Pro Leu Phe Val Gln Leu 
            580                 585                 590         


Leu Tyr Ser Ser Val Glu Asn Ile Gln Arg Val Ala Ala Gly Val Leu 
        595                 600                 605             


Cys Glu Leu Ala Gln Asp Lys Glu Ala Ala Asp Ala Ile Asp Ala Glu 
    610                 615                 620                 


Gly Ala Ser Ala Pro Leu Met Glu Leu Leu His Ser Arg Asn Glu Gly 
625                 630                 635                 640 


Thr Ala Thr Tyr Ala Ala Ala Val Leu Phe Arg Ile Ser Glu Asp Lys 
                645                 650                 655     


Asn Pro Asp Tyr Arg Lys Arg Val Ser Val Glu Leu Thr Asn Ser Leu 
            660                 665                 670         


Phe Lys His Asp Pro Ala Ala Trp Glu Ala Ala Gln Ser Met Ile Pro 
        675                 680                 685             


Ile Asn Glu Pro Tyr Gly Asp Asp Met Asp Ala Thr Tyr Arg Pro Met 
    690                 695                 700                 


Tyr Ser Ser Asp Val Pro Leu Asp Pro Leu Glu Met His Met Asp Met 
705                 710                 715                 720 


Asp Gly Asp Tyr Pro Ile Asp Thr Tyr Ser Asp Gly Leu Arg Pro Pro 
                725                 730                 735     


Tyr Pro Thr Ala Asp His Met Leu Ala 
            740                 745 


<210>  5685
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAL1__Homo_sapiens__NP_000207

<400>  5685

Met Val Pro Gly Val Pro Gly Ala Val Leu Thr Leu Cys Leu Trp Leu 
1               5                   10                  15      


Ala Ala Ser Ser Gly Cys Leu Ala Ala Gly Pro Gly Ala Ala Ala Ala 
            20                  25                  30          


Arg Arg Leu Asp Glu Ser Leu Ser Ala Gly Ser Val Gln Arg Ala Arg 
        35                  40                  45              


Cys Ala Ser Arg Cys Leu Ser Leu Gln Ile Thr Arg Ile Ser Ala Phe 
    50                  55                  60                  


Phe Gln His Phe Gln Asn Asn Gly Ser Leu Val Trp Cys Gln Asn His 
65                  70                  75                  80  


Lys Gln Cys Ser Lys Cys Leu Glu Pro Cys Lys Glu Ser Gly Asp Leu 
                85                  90                  95      


Arg Lys His Gln Cys Gln Ser Phe Cys Glu Pro Leu Phe Pro Lys Lys 
            100                 105                 110         


Ser Tyr Glu Cys Leu Thr Ser Cys Glu Phe Leu Lys Tyr Ile Leu Leu 
        115                 120                 125             


Val Lys Gln Gly Asp Cys Pro Ala Pro Glu Lys Ala Ser Gly Phe Ala 
    130                 135                 140                 


Ala Ala Cys Val Glu Ser Cys Glu Val Asp Asn Glu Cys Ser Gly Val 
145                 150                 155                 160 


Lys Lys Cys Cys Ser Asn Gly Cys Gly His Thr Cys Gln Val Pro Lys 
                165                 170                 175     


Thr Leu Tyr Lys Gly Val Pro Leu Lys Pro Arg Lys Glu Leu Arg Phe 
            180                 185                 190         


Thr Glu Leu Gln Ser Gly Gln Leu Glu Val Lys Trp Ser Ser Lys Phe 
        195                 200                 205             


Asn Ile Ser Ile Glu Pro Val Ile Tyr Val Val Gln Arg Arg Trp Asn 
    210                 215                 220                 


Tyr Gly Ile His Pro Ser Glu Asp Asp Ala Thr His Trp Gln Thr Val 
225                 230                 235                 240 


Ala Gln Thr Thr Asp Glu Arg Val Gln Leu Thr Asp Ile Arg Pro Ser 
                245                 250                 255     


Arg Trp Tyr Gln Phe Arg Val Ala Ala Val Asn Val His Gly Thr Arg 
            260                 265                 270         


Gly Phe Thr Ala Pro Ser Lys His Phe Arg Ser Ser Lys Asp Pro Ser 
        275                 280                 285             


Ala Pro Pro Ala Pro Ala Asn Leu Arg Leu Ala Asn Ser Thr Val Asn 
    290                 295                 300                 


Ser Asp Gly Ser Val Thr Val Thr Ile Val Trp Asp Leu Pro Glu Glu 
305                 310                 315                 320 


Pro Asp Ile Pro Val His His Tyr Lys Val Phe Trp Ser Trp Met Val 
                325                 330                 335     


Ser Ser Lys Ser Leu Val Pro Thr Lys Lys Lys Arg Arg Lys Thr Thr 
            340                 345                 350         


Asp Gly Phe Gln Asn Ser Val Ile Leu Glu Lys Leu Gln Pro Asp Cys 
        355                 360                 365             


Asp Tyr Val Val Glu Leu Gln Ala Ile Thr Tyr Trp Gly Gln Thr Arg 
    370                 375                 380                 


Leu Lys Ser Ala Lys Val Ser Leu His Phe Thr Ser Thr His Ala Thr 
385                 390                 395                 400 


Asn Asn Lys Glu Gln Leu Val Lys Thr Arg Lys Gly Gly Ile Gln Thr 
                405                 410                 415     


Gln Leu Pro Phe Gln Arg Arg Arg Pro Thr Arg Pro Leu Glu Val Gly 
            420                 425                 430         


Ala Pro Phe Tyr Gln Asp Gly Gln Leu Gln Val Lys Val Tyr Trp Lys 
        435                 440                 445             


Lys Thr Glu Asp Pro Thr Val Asn Arg Tyr His Val Arg Trp Phe Pro 
    450                 455                 460                 


Glu Ala Cys Ala His Asn Arg Thr Thr Gly Ser Glu Ala Ser Ser Gly 
465                 470                 475                 480 


Met Thr His Glu Asn Tyr Ile Ile Leu Gln Asp Leu Ser Phe Ser Cys 
                485                 490                 495     


Lys Tyr Lys Val Thr Val Gln Pro Ile Arg Pro Lys Ser His Ser Lys 
            500                 505                 510         


Ala Glu Ala Val Phe Phe Thr Thr Pro Pro Cys Ser Ala Leu Lys Gly 
        515                 520                 525             


Lys Ser His Lys Pro Val Gly Cys Leu Gly Glu Ala Gly His Val Leu 
    530                 535                 540                 


Ser Lys Val Leu Ala Lys Pro Glu Asn Leu Ser Ala Ser Phe Ile Val 
545                 550                 555                 560 


Gln Asp Val Asn Ile Thr Gly His Phe Ser Trp Lys Met Ala Lys Ala 
                565                 570                 575     


Asn Leu Tyr Gln Pro Met Thr Gly Phe Gln Val Thr Trp Ala Glu Val 
            580                 585                 590         


Thr Thr Glu Ser Arg Gln Asn Ser Leu Pro Asn Ser Ile Ile Ser Gln 
        595                 600                 605             


Ser Gln Ile Leu Pro Ser Asp His Tyr Val Leu Thr Val Pro Asn Leu 
    610                 615                 620                 


Arg Pro Ser Thr Leu Tyr Arg Leu Glu Val Gln Val Leu Thr Pro Gly 
625                 630                 635                 640 


Gly Glu Gly Pro Ala Thr Ile Lys Thr Phe Arg Thr Pro Glu Leu Pro 
                645                 650                 655     


Pro Ser Ser Ala His Arg Ser His Leu Lys His Arg His Pro His His 
            660                 665                 670         


Tyr Lys Pro Ser Pro Glu Arg Tyr 
        675                 680 


<210>  5686
<211>  2986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KALRN__Homo_sapiens__NP_001019831

<400>  5686

Met Thr Asp Arg Phe Trp Asp Gln Trp Tyr Leu Trp Tyr Leu Arg Leu 
1               5                   10                  15      


Leu Arg Leu Leu Asp Arg Gly Ser Phe Arg Asn Asp Gly Leu Lys Ala 
            20                  25                  30          


Ser Asp Val Leu Pro Ile Leu Lys Glu Lys Val Ala Phe Val Ser Gly 
        35                  40                  45              


Gly Arg Asp Lys Arg Gly Gly Pro Ile Leu Thr Phe Pro Ala Arg Ser 
    50                  55                  60                  


Asn His Asp Arg Ile Arg Gln Glu Asp Leu Arg Lys Leu Val Thr Tyr 
65                  70                  75                  80  


Leu Ala Ser Val Pro Ser Glu Asp Val Cys Lys Arg Gly Phe Thr Val 
                85                  90                  95      


Ile Ile Asp Met Arg Gly Ser Lys Trp Asp Leu Ile Lys Pro Leu Leu 
            100                 105                 110         


Lys Thr Leu Gln Glu Ala Phe Pro Ala Glu Ile His Val Ala Leu Ile 
        115                 120                 125             


Ile Lys Pro Asp Asn Phe Trp Gln Lys Gln Lys Thr Asn Phe Gly Ser 
    130                 135                 140                 


Ser Lys Phe Ile Phe Glu Thr Ser Met Val Ser Val Glu Gly Leu Thr 
145                 150                 155                 160 


Lys Leu Val Asp Pro Ser Gln Leu Thr Glu Glu Phe Asp Gly Ser Leu 
                165                 170                 175     


Asp Tyr Asn His Glu Glu Trp Ile Glu Leu Arg Leu Ser Leu Glu Glu 
            180                 185                 190         


Phe Phe Asn Ser Ala Val His Leu Leu Ser Arg Leu Glu Asp Leu Gln 
        195                 200                 205             


Glu Met Leu Ala Arg Lys Glu Phe Pro Val Asp Val Glu Gly Ser Arg 
    210                 215                 220                 


Arg Leu Ile Asp Glu His Thr Gln Leu Lys Lys Lys Val Leu Lys Ala 
225                 230                 235                 240 


Pro Val Glu Glu Leu Asp Arg Glu Gly Gln Arg Leu Leu Gln Cys Ile 
                245                 250                 255     


Arg Cys Ser Asp Gly Phe Ser Gly Arg Asn Cys Ile Pro Gly Ser Ala 
            260                 265                 270         


Asp Phe Gln Ser Leu Val Pro Lys Ile Thr Ser Leu Leu Asp Lys Leu 
        275                 280                 285             


His Ser Thr Arg Gln His Leu His Gln Met Trp His Val Arg Lys Leu 
    290                 295                 300                 


Lys Leu Asp Gln Cys Phe Gln Leu Arg Leu Phe Glu Gln Asp Ala Glu 
305                 310                 315                 320 


Lys Met Phe Asp Trp Ile Ser His Asn Lys Glu Leu Phe Leu Gln Ser 
                325                 330                 335     


His Thr Glu Ile Gly Val Ser Tyr Gln Tyr Ala Leu Asp Leu Gln Thr 
            340                 345                 350         


Gln His Asn His Phe Ala Met Asn Ser Met Asn Ala Tyr Val Asn Ile 
        355                 360                 365             


Asn Arg Ile Met Ser Val Ala Ser Arg Leu Ser Glu Ala Gly His Tyr 
    370                 375                 380                 


Ala Ser Gln Gln Ile Lys Gln Ile Ser Thr Gln Leu Asp Gln Glu Trp 
385                 390                 395                 400 


Lys Ser Phe Ala Ala Ala Leu Asp Glu Arg Ser Thr Ile Leu Ala Met 
                405                 410                 415     


Ser Ala Val Phe His Gln Lys Ala Glu Gln Phe Leu Ser Gly Val Asp 
            420                 425                 430         


Ala Trp Cys Lys Met Cys Ser Glu Gly Gly Leu Pro Ser Glu Met Gln 
        435                 440                 445             


Asp Leu Glu Leu Ala Ile His His His Gln Thr Leu Tyr Glu Gln Val 
    450                 455                 460                 


Thr Gln Ala Tyr Thr Glu Val Ser Gln Asp Gly Lys Ala Leu Leu Asp 
465                 470                 475                 480 


Val Leu Gln Arg Pro Leu Ser Pro Gly Asn Ser Glu Ser Leu Thr Ala 
                485                 490                 495     


Thr Ala Asn Tyr Ser Lys Ala Val His Gln Val Leu Asp Val Val His 
            500                 505                 510         


Glu Val Leu His His Gln Arg Arg Leu Glu Ser Ile Trp Gln His Arg 
        515                 520                 525             


Lys Val Arg Leu His Gln Arg Leu Gln Leu Cys Val Phe Gln Gln Asp 
    530                 535                 540                 


Val Gln Gln Val Leu Asp Trp Ile Glu Asn His Gly Glu Ala Phe Leu 
545                 550                 555                 560 


Ser Lys His Thr Gly Val Gly Lys Ser Leu His Arg Ala Arg Ala Leu 
                565                 570                 575     


Gln Lys Arg His Asp Asp Phe Glu Glu Val Ala Gln Asn Thr Tyr Thr 
            580                 585                 590         


Asn Ala Asp Lys Leu Leu Glu Ala Ala Glu Gln Leu Ala Gln Thr Gly 
        595                 600                 605             


Glu Cys Asp Pro Glu Glu Ile Tyr Lys Ala Ala Arg His Leu Glu Val 
    610                 615                 620                 


Arg Ile Gln Asp Phe Val Arg Arg Val Glu Gln Arg Lys Leu Leu Leu 
625                 630                 635                 640 


Asp Met Ser Val Ser Phe His Thr His Thr Lys Glu Leu Trp Thr Trp 
                645                 650                 655     


Met Glu Asp Leu Gln Lys Glu Met Leu Glu Asp Val Cys Ala Asp Ser 
            660                 665                 670         


Val Asp Ala Val Gln Glu Leu Ile Lys Gln Phe Gln Gln Gln Gln Thr 
        675                 680                 685             


Ala Thr Leu Asp Ala Thr Leu Asn Val Ile Lys Glu Gly Glu Asp Leu 
    690                 695                 700                 


Ile Gln Gln Leu Arg Ser Ala Pro Pro Ser Leu Gly Glu Pro Ser Glu 
705                 710                 715                 720 


Ala Arg Asp Ser Ala Val Ser Asn Asn Lys Thr Pro His Ser Ser Ser 
                725                 730                 735     


Ile Ser His Ile Glu Ser Val Leu Gln Gln Leu Asp Asp Ala Gln Val 
            740                 745                 750         


Gln Met Glu Glu Leu Phe His Glu Arg Lys Ile Lys Leu Asp Ile Phe 
        755                 760                 765             


Leu Gln Leu Arg Ile Phe Glu Gln Tyr Thr Ile Glu Val Thr Ala Glu 
    770                 775                 780                 


Leu Asp Ala Trp Asn Glu Asp Leu Leu Arg Gln Met Asn Asp Phe Asn 
785                 790                 795                 800 


Thr Glu Asp Leu Thr Leu Ala Glu Gln Arg Leu Gln Arg His Thr Glu 
                805                 810                 815     


Arg Lys Leu Ala Met Asn Asn Met Thr Phe Glu Val Ile Gln Gln Gly 
            820                 825                 830         


Gln Asp Leu His Gln Tyr Ile Thr Glu Val Gln Ala Ser Gly Ile Glu 
        835                 840                 845             


Leu Ile Cys Glu Lys Asp Ile Asp Leu Ala Ala Gln Val Gln Glu Leu 
    850                 855                 860                 


Leu Glu Phe Leu His Glu Lys Gln His Glu Leu Glu Leu Asn Ala Glu 
865                 870                 875                 880 


Gln Thr His Lys Arg Leu Glu Gln Cys Leu Gln Leu Arg His Leu Gln 
                885                 890                 895     


Ala Glu Val Lys Gln Val Leu Gly Trp Ile Arg Asn Gly Glu Ser Met 
            900                 905                 910         


Leu Asn Ala Ser Leu Val Asn Ala Ser Ser Leu Ser Glu Ala Glu Gln 
        915                 920                 925             


Leu Gln Arg Glu His Glu Gln Phe Gln Leu Ala Ile Glu Ser Leu Phe 
    930                 935                 940                 


His Ala Thr Ser Leu Gln Lys Thr His Gln Ser Ala Leu Gln Val Gln 
945                 950                 955                 960 


Gln Lys Ala Glu Val Leu Leu Gln Ala Gly His Tyr Asp Ala Asp Ala 
                965                 970                 975     


Ile Arg Glu Cys Ala Glu Lys Val Ala Leu His Trp Gln Gln Leu Met 
            980                 985                 990         


Leu Lys Met Glu Asp Arg Leu Lys  Leu Val Asn Ala Ser  Val Ala Phe 
        995                 1000                 1005             


Tyr Lys  Thr Ser Glu Gln Val  Cys Ser Val Leu Glu  Ser Leu Glu 
    1010                 1015                 1020             


Gln Glu  Tyr Arg Arg Asp Glu  Asp Trp Cys Gly Gly  Arg Asp Lys 
    1025                 1030                 1035             


Leu Gly  Pro Ala Ala Glu Ile  Asp His Val Ile Pro  Leu Ile Ser 
    1040                 1045                 1050             


Lys His  Leu Glu Gln Lys Glu  Ala Phe Leu Lys Ala  Cys Thr Leu 
    1055                 1060                 1065             


Ala Arg  Arg Asn Ala Glu Val  Phe Leu Lys Tyr Ile  His Arg Asn 
    1070                 1075                 1080             


Asn Val  Ser Met Pro Ser Val  Ala Ser His Thr Arg  Gly Pro Glu 
    1085                 1090                 1095             


Gln Gln  Val Lys Ala Ile Leu  Ser Glu Leu Leu Gln  Arg Glu Asn 
    1100                 1105                 1110             


Arg Val  Leu His Phe Trp Thr  Leu Lys Lys Arg Arg  Leu Asp Gln 
    1115                 1120                 1125             


Cys Gln  Gln Tyr Val Val Phe  Glu Arg Ser Ala Lys  Gln Ala Leu 
    1130                 1135                 1140             


Asp Trp  Ile Gln Glu Thr Gly  Glu Phe Tyr Leu Ser  Thr His Thr 
    1145                 1150                 1155             


Ser Thr  Gly Glu Thr Thr Glu  Glu Thr Gln Glu Leu  Leu Lys Glu 
    1160                 1165                 1170             


Tyr Gly  Glu Phe Arg Val Pro  Ala Lys Gln Thr Lys  Glu Lys Val 
    1175                 1180                 1185             


Lys Leu  Leu Ile Gln Leu Ala  Asp Ser Phe Val Glu  Lys Gly His 
    1190                 1195                 1200             


Ile His  Ala Thr Glu Ile Arg  Lys Trp Val Thr Thr  Val Asp Lys 
    1205                 1210                 1215             


His Tyr  Arg Asp Phe Ser Leu  Arg Met Gly Lys Tyr  Arg Tyr Ser 
    1220                 1225                 1230             


Leu Glu  Lys Ala Leu Gly Val  Asn Thr Glu Asp Asn  Lys Asp Leu 
    1235                 1240                 1245             


Glu Leu  Asp Ile Ile Pro Ala  Ser Leu Ser Asp Arg  Glu Val Lys 
    1250                 1255                 1260             


Leu Arg  Asp Ala Asn His Glu  Val Asn Glu Glu Lys  Arg Lys Ser 
    1265                 1270                 1275             


Ala Arg  Lys Lys Glu Phe Ile  Met Ala Glu Leu Leu  Gln Thr Glu 
    1280                 1285                 1290             


Lys Ala  Tyr Val Arg Asp Leu  His Glu Cys Leu Glu  Thr Tyr Leu 
    1295                 1300                 1305             


Trp Glu  Met Thr Ser Gly Val  Glu Glu Ile Pro Pro  Gly Ile Leu 
    1310                 1315                 1320             


Asn Lys  Glu His Ile Ile Phe  Gly Asn Ile Gln Glu  Ile Tyr Asp 
    1325                 1330                 1335             


Phe His  Asn Asn Ile Phe Leu  Lys Glu Leu Glu Lys  Tyr Glu Gln 
    1340                 1345                 1350             


Leu Pro  Glu Asp Val Gly His  Cys Phe Val Thr Trp  Ala Asp Lys 
    1355                 1360                 1365             


Phe Gln  Met Tyr Val Thr Tyr  Cys Lys Asn Lys Pro  Asp Ser Asn 
    1370                 1375                 1380             


Gln Leu  Ile Leu Glu His Ala  Gly Thr Phe Phe Asp  Glu Ile Gln 
    1385                 1390                 1395             


Gln Arg  His Gly Leu Ala Asn  Ser Ile Ser Ser Tyr  Leu Ile Lys 
    1400                 1405                 1410             


Pro Val  Gln Arg Ile Thr Lys  Tyr Gln Leu Leu Leu  Lys Glu Leu 
    1415                 1420                 1425             


Leu Thr  Cys Cys Glu Glu Gly  Lys Gly Glu Leu Lys  Asp Gly Leu 
    1430                 1435                 1440             


Glu Val  Met Leu Ser Val Pro  Lys Lys Ala Asn Asp  Ala Met His 
    1445                 1450                 1455             


Val Ser  Met Leu Glu Gly Phe  Asp Glu Asn Leu Asp  Val Gln Gly 
    1460                 1465                 1470             


Glu Leu  Ile Leu Gln Asp Ala  Phe Gln Val Trp Asp  Pro Lys Ser 
    1475                 1480                 1485             


Leu Ile  Arg Lys Gly Arg Glu  Arg His Leu Phe Leu  Phe Glu Ile 
    1490                 1495                 1500             


Ser Leu  Val Phe Ser Lys Glu  Ile Lys Asp Ser Ser  Gly His Thr 
    1505                 1510                 1515             


Lys Tyr  Val Tyr Lys Asn Lys  Leu Leu Thr Ser Glu  Leu Gly Val 
    1520                 1525                 1530             


Thr Glu  His Val Glu Gly Asp  Pro Cys Lys Phe Ala  Leu Trp Ser 
    1535                 1540                 1545             


Gly Arg  Thr Pro Ser Ser Asp  Asn Lys Thr Val Leu  Lys Ala Ser 
    1550                 1555                 1560             


Asn Ile  Glu Thr Lys Gln Glu  Trp Ile Lys Asn Ile  Arg Glu Val 
    1565                 1570                 1575             


Ile Gln  Glu Arg Ile Ile His  Leu Lys Gly Ala Leu  Lys Glu Pro 
    1580                 1585                 1590             


Leu Gln  Leu Pro Lys Thr Pro  Ala Lys Gln Arg Asn  Asn Ser Lys 
    1595                 1600                 1605             


Arg Asp  Gly Val Glu Asp Ile  Asp Ser Gln Gly Asp  Gly Ser Ser 
    1610                 1615                 1620             


Gln Pro  Asp Thr Ile Ser Ile  Ala Ser Arg Thr Ser  Gln Asn Thr 
    1625                 1630                 1635             


Val Asp  Ser Asp Lys Leu Ser  Gly Gly Cys Glu Leu  Thr Val Val 
    1640                 1645                 1650             


Leu Gln  Asp Phe Ser Ala Gly  His Ser Ser Glu Leu  Thr Ile Gln 
    1655                 1660                 1665             


Val Gly  Gln Thr Val Glu Leu  Leu Glu Arg Pro Ser  Glu Arg Pro 
    1670                 1675                 1680             


Gly Trp  Cys Leu Val Arg Thr  Thr Glu Arg Ser Pro  Pro Leu Glu 
    1685                 1690                 1695             


Gly Leu  Val Pro Ser Ser Ala  Leu Cys Ile Ser His  Ser Arg Ser 
    1700                 1705                 1710             


Ser Val  Glu Met Asp Cys Phe  Phe Pro Leu Val Lys  Asp Ala Tyr 
    1715                 1720                 1725             


Ser His  Ser Ser Ser Glu Asn  Gly Gly Lys Ser Glu  Ser Val Ala 
    1730                 1735                 1740             


Asn Leu  Gln Ala Gln Pro Ser  Leu Asn Ser Ile His  Ser Ser Pro 
    1745                 1750                 1755             


Gly Pro  Lys Arg Ser Thr Asn  Thr Leu Lys Lys Trp  Leu Thr Ser 
    1760                 1765                 1770             


Pro Val  Arg Arg Leu Asn Ser  Gly Lys Ala Asp Gly  Asn Ile Lys 
    1775                 1780                 1785             


Lys Gln  Lys Lys Val Arg Asp  Gly Arg Lys Ser Phe  Asp Leu Gly 
    1790                 1795                 1800             


Ser Pro  Lys Pro Gly Asp Glu  Thr Thr Pro Gln Gly  Asp Ser Ala 
    1805                 1810                 1815             


Asp Glu  Lys Ser Lys Lys Gly  Trp Gly Glu Asp Glu  Pro Asp Glu 
    1820                 1825                 1830             


Glu Ser  His Thr Pro Leu Pro  Pro Pro Met Lys Ile  Phe Asp Asn 
    1835                 1840                 1845             


Asp Pro  Thr Gln Asp Glu Met  Ser Ser Ser Leu Leu  Ala Ala Arg 
    1850                 1855                 1860             


Gln Ala  Ser Thr Glu Val Pro  Thr Ala Ala Asp Leu  Val Asn Ala 
    1865                 1870                 1875             


Ile Glu  Lys Leu Val Lys Asn  Lys Leu Ser Leu Glu  Gly Ser Ser 
    1880                 1885                 1890             


Tyr Arg  Gly Ser Leu Lys Asp  Pro Ala Gly Cys Leu  Asn Glu Gly 
    1895                 1900                 1905             


Met Ala  Pro Pro Thr Pro Pro  Lys Asn Pro Glu Glu  Glu Gln Lys 
    1910                 1915                 1920             


Ala Lys  Ala Leu Arg Gly Arg  Met Phe Val Leu Asn  Glu Leu Val 
    1925                 1930                 1935             


Gln Thr  Glu Lys Asp Tyr Val  Lys Asp Leu Gly Ile  Val Val Glu 
    1940                 1945                 1950             


Gly Phe  Met Lys Arg Ile Glu  Glu Lys Gly Val Pro  Glu Asp Met 
    1955                 1960                 1965             


Arg Gly  Lys Asp Lys Ile Val  Phe Gly Asn Ile His  Gln Ile Tyr 
    1970                 1975                 1980             


Asp Trp  His Lys Asp Phe Phe  Leu Ala Glu Leu Glu  Lys Cys Ile 
    1985                 1990                 1995             


Gln Glu  Gln Asp Arg Leu Ala  Gln Leu Phe Ile Lys  His Glu Arg 
    2000                 2005                 2010             


Lys Leu  His Ile Tyr Val Trp  Tyr Cys Gln Asn Lys  Pro Arg Ser 
    2015                 2020                 2025             


Glu Tyr  Ile Val Ala Glu Tyr  Asp Ala Tyr Phe Glu  Glu Val Lys 
    2030                 2035                 2040             


Gln Glu  Ile Asn Gln Arg Leu  Thr Leu Ser Asp Phe  Leu Ile Lys 
    2045                 2050                 2055             


Pro Ile  Gln Arg Ile Thr Lys  Tyr Gln Leu Leu Leu  Lys Asp Phe 
    2060                 2065                 2070             


Leu Arg  Tyr Ser Glu Lys Ala  Gly Leu Glu Cys Ser  Asp Ile Glu 
    2075                 2080                 2085             


Lys Ala  Val Glu Leu Met Cys  Leu Val Pro Lys Arg  Cys Asn Asp 
    2090                 2095                 2100             


Met Met  Asn Leu Gly Arg Leu  Gln Gly Phe Glu Gly  Thr Leu Thr 
    2105                 2110                 2115             


Ala Gln  Gly Lys Leu Leu Gln  Gln Asp Thr Phe Tyr  Val Ile Glu 
    2120                 2125                 2130             


Leu Asp  Ala Gly Met Gln Ser  Arg Thr Lys Glu Arg  Arg Val Phe 
    2135                 2140                 2145             


Leu Phe  Glu Gln Ile Val Ile  Phe Ser Glu Leu Leu  Arg Lys Gly 
    2150                 2155                 2160             


Ser Leu  Thr Pro Gly Tyr Met  Phe Lys Arg Ser Ile  Lys Met Asn 
    2165                 2170                 2175             


Tyr Leu  Val Leu Glu Glu Asn  Val Asp Asn Asp Pro  Cys Lys Phe 
    2180                 2185                 2190             


Ala Leu  Met Asn Arg Glu Thr  Ser Glu Arg Val Val  Leu Gln Ala 
    2195                 2200                 2205             


Ala Asn  Ala Asp Ile Gln Gln  Ala Trp Val Gln Asp  Ile Asn Gln 
    2210                 2215                 2220             


Val Leu  Glu Thr Gln Arg Asp  Phe Leu Asn Ala Leu  Gln Ser Pro 
    2225                 2230                 2235             


Ile Glu  Tyr Gln Arg Lys Glu  Arg Ser Thr Ala Val  Met Arg Ser 
    2240                 2245                 2250             


Gln Pro  Ala Arg Leu Pro Gln  Ala Ser Pro Arg Pro  Tyr Ser Ser 
    2255                 2260                 2265             


Val Pro  Ala Gly Ser Glu Lys  Pro Pro Lys Gly Ser  Ser Tyr Asn 
    2270                 2275                 2280             


Pro Pro  Leu Pro Pro Leu Lys  Ile Ser Thr Ser Asn  Gly Ser Pro 
    2285                 2290                 2295             


Gly Phe  Glu Tyr His Gln Pro  Gly Asp Lys Phe Glu  Ala Ser Lys 
    2300                 2305                 2310             


Gln Asn  Asp Leu Gly Gly Cys  Asn Gly Thr Ser Ser  Met Ala Val 
    2315                 2320                 2325             


Ile Lys  Asp Tyr Tyr Ala Leu  Lys Glu Asn Glu Ile  Cys Val Ser 
    2330                 2335                 2340             


Gln Gly  Glu Val Val Gln Val  Leu Ala Val Asn Gln  Gln Asn Met 
    2345                 2350                 2355             


Cys Leu  Val Tyr Gln Pro Ala  Ser Asp His Ser Pro  Ala Ala Glu 
    2360                 2365                 2370             


Gly Trp  Val Pro Gly Ser Ile  Leu Ala Pro Leu Thr  Lys Ala Thr 
    2375                 2380                 2385             


Ala Ala  Glu Ser Ser Asp Gly  Ser Ile Lys Lys Ser  Cys Ser Trp 
    2390                 2395                 2400             


His Thr  Leu Arg Met Arg Lys  Arg Ala Glu Val Glu  Asn Thr Gly 
    2405                 2410                 2415             


Lys Asn  Glu Ala Thr Gly Pro  Arg Lys Pro Lys Asp  Ile Leu Gly 
    2420                 2425                 2430             


Asn Lys  Val Ser Val Lys Glu  Thr Asn Ser Ser Glu  Glu Ser Glu 
    2435                 2440                 2445             


Cys Asp  Asp Leu Asp Pro Asn  Thr Ser Met Glu Ile  Leu Asn Pro 
    2450                 2455                 2460             


Asn Phe  Ile Gln Glu Val Ala  Pro Glu Phe Leu Val  Pro Leu Val 
    2465                 2470                 2475             


Asp Val  Thr Cys Leu Leu Gly  Asp Thr Val Ile Leu  Gln Cys Lys 
    2480                 2485                 2490             


Val Cys  Gly Arg Pro Lys Pro  Thr Ile Thr Trp Lys  Gly Pro Asp 
    2495                 2500                 2505             


Gln Asn  Ile Leu Asp Thr Asp  Asn Ser Ser Ala Thr  Tyr Thr Val 
    2510                 2515                 2520             


Ser Ser  Cys Asp Ser Gly Glu  Ile Thr Leu Lys Ile  Cys Asn Leu 
    2525                 2530                 2535             


Met Pro  Gln Asp Ser Gly Ile  Tyr Thr Cys Ile Ala  Thr Asn Asp 
    2540                 2545                 2550             


His Gly  Thr Thr Ser Thr Ser  Ala Thr Val Lys Val  Gln Gly Val 
    2555                 2560                 2565             


Pro Ala  Ala Pro Asn Arg Pro  Ile Ala Gln Glu Arg  Ser Cys Thr 
    2570                 2575                 2580             


Ser Val  Ile Leu Arg Trp Leu  Pro Pro Ser Ser Thr  Gly Asn Cys 
    2585                 2590                 2595             


Thr Ile  Ser Gly Tyr Thr Val  Glu Tyr Arg Glu Glu  Gly Ser Gln 
    2600                 2605                 2610             


Ile Trp  Gln Gln Ser Val Ala  Ser Thr Leu Asp Thr  Tyr Leu Val 
    2615                 2620                 2625             


Ile Glu  Asp Leu Ser Pro Gly  Cys Pro Tyr Gln Phe  Arg Val Ser 
    2630                 2635                 2640             


Ala Ser  Asn Pro Trp Gly Ile  Ser Leu Pro Ser Glu  Pro Ser Glu 
    2645                 2650                 2655             


Phe Val  Arg Leu Pro Glu Tyr  Asp Ala Ala Ala Asp  Gly Ala Thr 
    2660                 2665                 2670             


Ile Ser  Trp Lys Glu Asn Phe  Asp Ser Ala Tyr Thr  Glu Leu Asn 
    2675                 2680                 2685             


Glu Ile  Gly Arg Gly Arg Phe  Ser Ile Val Lys Lys  Cys Ile His 
    2690                 2695                 2700             


Lys Ala  Thr Arg Lys Asp Val  Ala Val Lys Phe Val  Ser Lys Lys 
    2705                 2710                 2715             


Met Lys  Lys Lys Glu Gln Ala  Ala His Glu Ala Ala  Leu Leu Gln 
    2720                 2725                 2730             


His Leu  Gln His Pro Gln Tyr  Ile Thr Leu His Asp  Thr Tyr Glu 
    2735                 2740                 2745             


Ser Pro  Thr Ser Tyr Ile Leu  Ile Leu Glu Leu Met  Asp Asp Gly 
    2750                 2755                 2760             


Arg Leu  Leu Asp Tyr Leu Met  Asn His Asp Glu Leu  Met Glu Glu 
    2765                 2770                 2775             


Lys Val  Ala Phe Tyr Ile Arg  Asp Ile Met Glu Ala  Leu Gln Tyr 
    2780                 2785                 2790             


Leu His  Asn Cys Arg Val Ala  His Leu Asp Ile Lys  Pro Glu Asn 
    2795                 2800                 2805             


Leu Leu  Ile Asp Leu Arg Ile  Pro Val Pro Arg Val  Lys Leu Ile 
    2810                 2815                 2820             


Asp Leu  Glu Asp Ala Val Gln  Ile Ser Gly His Phe  His Ile His 
    2825                 2830                 2835             


His Leu  Leu Gly Asn Pro Glu  Phe Ala Ala Pro Glu  Val Ile Gln 
    2840                 2845                 2850             


Gly Ile  Pro Val Ser Leu Gly  Thr Asp Ile Trp Ser  Ile Gly Val 
    2855                 2860                 2865             


Leu Thr  Tyr Val Met Leu Ser  Gly Val Ser Pro Phe  Leu Asp Glu 
    2870                 2875                 2880             


Ser Lys  Glu Glu Thr Cys Ile  Asn Val Cys Arg Val  Asp Phe Ser 
    2885                 2890                 2895             


Phe Pro  His Glu Tyr Phe Cys  Gly Val Ser Asn Ala  Ala Arg Asp 
    2900                 2905                 2910             


Phe Ile  Asn Val Ile Leu Gln  Glu Asp Phe Arg Arg  Arg Pro Thr 
    2915                 2920                 2925             


Ala Ala  Thr Cys Leu Gln His  Pro Trp Leu Gln Pro  His Asn Gly 
    2930                 2935                 2940             


Ser Tyr  Ser Lys Ile Pro Leu  Asp Thr Ser Arg Leu  Ala Cys Phe 
    2945                 2950                 2955             


Ile Glu  Arg Arg Lys His Gln  Asn Asp Val Arg Pro  Ile Pro Asn 
    2960                 2965                 2970             


Val Lys  Ser Tyr Ile Val Asn  Arg Val Asn Gln Gly  Thr 
    2975                 2980                 2985     


<210>  5687
<211>  1352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KANK1__Homo_sapiens__NP_001243806

<400>  5687

Met Ala His Thr Thr Lys Val Asn Gly Ser Ala Ser Gly Lys Ala Gly 
1               5                   10                  15      


Asp Ile Leu Ser Gly Asp Gln Asp Lys Glu Gln Lys Asp Pro Tyr Phe 
            20                  25                  30          


Val Glu Thr Pro Tyr Gly Tyr Gln Leu Asp Leu Asp Phe Leu Lys Tyr 
        35                  40                  45              


Val Asp Asp Ile Gln Lys Gly Asn Thr Ile Lys Arg Leu Asn Ile Gln 
    50                  55                  60                  


Lys Arg Arg Lys Pro Ser Val Pro Cys Pro Glu Pro Arg Thr Thr Ser 
65                  70                  75                  80  


Gly Gln Gln Gly Ile Trp Thr Ser Thr Glu Ser Leu Ser Ser Ser Asn 
                85                  90                  95      


Ser Asp Asp Asn Lys Gln Cys Pro Asn Phe Leu Ile Ala Arg Ser Gln 
            100                 105                 110         


Val Thr Ser Thr Pro Ile Ser Lys Pro Pro Pro Pro Leu Glu Thr Ser 
        115                 120                 125             


Leu Pro Phe Leu Thr Ile Pro Glu Asn Arg Gln Leu Pro Pro Pro Ser 
    130                 135                 140                 


Pro Gln Leu Pro Lys His Asn Leu His Val Thr Lys Thr Leu Met Glu 
145                 150                 155                 160 


Thr Arg Arg Arg Leu Glu Gln Glu Arg Ala Thr Met Gln Met Thr Pro 
                165                 170                 175     


Gly Glu Phe Arg Arg Pro Arg Leu Ala Ser Phe Gly Gly Met Gly Thr 
            180                 185                 190         


Thr Ser Ser Leu Pro Ser Phe Val Gly Ser Gly Asn His Asn Pro Ala 
        195                 200                 205             


Lys His Gln Leu Gln Asn Gly Tyr Gln Gly Asn Gly Asp Tyr Gly Ser 
    210                 215                 220                 


Tyr Ala Pro Ala Ala Pro Thr Thr Ser Ser Met Gly Ser Ser Ile Arg 
225                 230                 235                 240 


His Ser Pro Leu Ser Ser Gly Ile Ser Thr Pro Val Thr Asn Val Ser 
                245                 250                 255     


Pro Met His Leu Gln His Ile Arg Glu Gln Met Ala Ile Ala Leu Lys 
            260                 265                 270         


Arg Leu Lys Glu Leu Glu Glu Gln Val Arg Thr Ile Pro Val Leu Gln 
        275                 280                 285             


Val Lys Ile Ser Val Leu Gln Glu Glu Lys Arg Gln Leu Val Ser Gln 
    290                 295                 300                 


Leu Lys Asn Gln Arg Ala Ala Ser Gln Ile Asn Val Cys Gly Val Arg 
305                 310                 315                 320 


Lys Arg Ser Tyr Ser Ala Gly Asn Ala Ser Gln Leu Glu Gln Leu Ser 
                325                 330                 335     


Arg Ala Arg Arg Ser Gly Gly Glu Leu Tyr Ile Asp Tyr Glu Glu Glu 
            340                 345                 350         


Glu Met Glu Thr Val Glu Gln Ser Thr Gln Arg Ile Lys Glu Phe Arg 
        355                 360                 365             


Gln Leu Thr Ala Asp Met Gln Ala Leu Glu Gln Lys Ile Gln Asp Ser 
    370                 375                 380                 


Ser Cys Glu Ala Ser Ser Glu Leu Arg Glu Asn Gly Glu Cys Arg Ser 
385                 390                 395                 400 


Val Ala Val Gly Ala Glu Glu Asn Met Asn Asp Ile Val Val Tyr His 
                405                 410                 415     


Arg Gly Ser Arg Ser Cys Lys Asp Ala Ala Val Gly Thr Leu Val Glu 
            420                 425                 430         


Met Arg Asn Cys Gly Val Ser Val Thr Glu Ala Met Leu Gly Val Met 
        435                 440                 445             


Thr Glu Ala Asp Lys Glu Ile Glu Leu Gln Gln Gln Thr Ile Glu Ser 
    450                 455                 460                 


Leu Lys Glu Lys Ile Tyr Arg Leu Glu Val Gln Leu Arg Glu Thr Thr 
465                 470                 475                 480 


His Asp Arg Glu Met Thr Lys Leu Lys Gln Glu Leu Gln Ala Ala Gly 
                485                 490                 495     


Ser Arg Lys Lys Val Asp Lys Ala Thr Met Ala Gln Pro Leu Val Phe 
            500                 505                 510         


Ser Lys Val Val Glu Ala Val Val Gln Thr Arg Asp Gln Met Val Gly 
        515                 520                 525             


Ser His Met Asp Leu Val Asp Thr Cys Val Gly Thr Ser Val Glu Thr 
    530                 535                 540                 


Asn Ser Val Gly Ile Ser Cys Gln Pro Glu Cys Lys Asn Lys Val Val 
545                 550                 555                 560 


Gly Pro Glu Leu Pro Met Asn Trp Trp Ile Val Lys Glu Arg Val Glu 
                565                 570                 575     


Met His Asp Arg Cys Ala Gly Arg Ser Val Glu Met Cys Asp Lys Ser 
            580                 585                 590         


Val Ser Val Glu Val Ser Val Cys Glu Thr Gly Ser Asn Thr Glu Glu 
        595                 600                 605             


Ser Val Asn Asp Leu Thr Leu Leu Lys Thr Asn Leu Asn Leu Lys Glu 
    610                 615                 620                 


Val Arg Ser Ile Gly Cys Gly Asp Cys Ser Val Asp Val Thr Val Cys 
625                 630                 635                 640 


Ser Pro Lys Glu Cys Ala Ser Arg Gly Val Asn Thr Glu Ala Val Ser 
                645                 650                 655     


Gln Val Glu Ala Ala Val Met Ala Val Pro Arg Thr Ala Asp Gln Asp 
            660                 665                 670         


Thr Ser Thr Asp Leu Glu Gln Val His Gln Phe Thr Asn Thr Glu Thr 
        675                 680                 685             


Ala Thr Leu Ile Glu Ser Cys Thr Asn Thr Cys Leu Ser Thr Leu Asp 
    690                 695                 700                 


Lys Gln Thr Ser Thr Gln Thr Val Glu Thr Arg Thr Val Ala Val Gly 
705                 710                 715                 720 


Glu Gly Arg Val Lys Asp Ile Asn Ser Ser Thr Lys Thr Arg Ser Ile 
                725                 730                 735     


Gly Val Gly Thr Leu Leu Ser Gly His Ser Gly Phe Asp Arg Pro Ser 
            740                 745                 750         


Ala Val Lys Thr Lys Glu Ser Gly Val Gly Gln Ile Asn Ile Asn Asp 
        755                 760                 765             


Asn Tyr Leu Val Gly Leu Lys Met Arg Thr Ile Ala Cys Gly Pro Pro 
    770                 775                 780                 


Gln Leu Thr Val Gly Leu Thr Ala Ser Arg Arg Ser Val Gly Val Gly 
785                 790                 795                 800 


Asp Asp Pro Val Gly Glu Ser Leu Glu Asn Pro Gln Pro Gln Ala Pro 
                805                 810                 815     


Leu Gly Met Met Thr Gly Leu Asp His Tyr Ile Glu Arg Ile Gln Lys 
            820                 825                 830         


Leu Leu Ala Glu Gln Gln Thr Leu Leu Ala Glu Asn Tyr Ser Glu Leu 
        835                 840                 845             


Ala Glu Ala Phe Gly Glu Pro His Ser Gln Met Gly Ser Leu Asn Ser 
    850                 855                 860                 


Gln Leu Ile Ser Thr Leu Ser Ser Ile Asn Ser Val Met Lys Ser Ala 
865                 870                 875                 880 


Ser Thr Glu Glu Leu Arg Asn Pro Asp Phe Gln Lys Thr Ser Leu Gly 
                885                 890                 895     


Lys Ile Thr Gly Asn Tyr Leu Gly Tyr Thr Cys Lys Cys Gly Gly Leu 
            900                 905                 910         


Gln Ser Gly Ser Pro Leu Ser Ser Gln Thr Ser Gln Pro Glu Gln Glu 
        915                 920                 925             


Val Gly Thr Ser Glu Gly Lys Pro Ile Ser Ser Leu Asp Ala Phe Pro 
    930                 935                 940                 


Thr Gln Glu Gly Thr Leu Ser Pro Val Asn Leu Thr Asp Asp Gln Ile 
945                 950                 955                 960 


Ala Ala Gly Leu Tyr Ala Cys Thr Asn Asn Glu Ser Thr Leu Lys Ser 
                965                 970                 975     


Ile Met Lys Lys Lys Asp Gly Asn Lys Asp Ser Asn Gly Ala Lys Lys 
            980                 985                 990         


Asn Leu Gln Phe Val Gly Ile Asn  Gly Gly Tyr Glu Thr  Thr Ser Ser 
        995                 1000                 1005             


Asp Asp  Ser Ser Ser Asp Glu  Ser Ser Ser Ser Glu  Ser Asp Asp 
    1010                 1015                 1020             


Glu Cys  Asp Val Ile Glu Tyr  Pro Leu Glu Glu Glu  Glu Glu Glu 
    1025                 1030                 1035             


Glu Asp  Glu Asp Thr Arg Gly  Met Ala Glu Gly His  His Ala Val 
    1040                 1045                 1050             


Asn Ile  Glu Gly Leu Lys Ser  Ala Arg Val Glu Asp  Glu Met Gln 
    1055                 1060                 1065             


Val Gln  Glu Cys Glu Pro Glu  Lys Val Glu Ile Arg  Glu Arg Tyr 
    1070                 1075                 1080             


Glu Leu  Ser Glu Lys Met Leu  Ser Ala Cys Asn Leu  Leu Lys Asn 
    1085                 1090                 1095             


Thr Ile  Asn Asp Pro Lys Ala  Leu Thr Ser Lys Asp  Met Arg Phe 
    1100                 1105                 1110             


Cys Leu  Asn Thr Leu Gln His  Glu Trp Phe Arg Val  Ser Ser Gln 
    1115                 1120                 1125             


Lys Ser  Ala Ile Pro Ala Met  Val Gly Asp Tyr Ile  Ala Ala Phe 
    1130                 1135                 1140             


Glu Ala  Ile Ser Pro Asp Val  Leu Arg Tyr Val Ile  Asn Leu Ala 
    1145                 1150                 1155             


Asp Gly  Asn Gly Asn Thr Ala  Leu His Tyr Ser Val  Ser His Ser 
    1160                 1165                 1170             


Asn Phe  Glu Ile Val Lys Leu  Leu Leu Asp Ala Asp  Val Cys Asn 
    1175                 1180                 1185             


Val Asp  His Gln Asn Lys Ala  Gly Tyr Thr Pro Ile  Met Leu Ala 
    1190                 1195                 1200             


Ala Leu  Ala Ala Val Glu Ala  Glu Lys Asp Met Arg  Ile Val Glu 
    1205                 1210                 1215             


Glu Leu  Phe Gly Cys Gly Asp  Val Asn Ala Lys Ala  Ser Gln Ala 
    1220                 1225                 1230             


Gly Gln  Thr Ala Leu Met Leu  Ala Val Ser His Gly  Arg Ile Asp 
    1235                 1240                 1245             


Met Val  Lys Gly Leu Leu Ala  Cys Gly Ala Asp Val  Asn Ile Gln 
    1250                 1255                 1260             


Asp Asp  Glu Gly Ser Thr Ala  Leu Met Cys Ala Ser  Glu His Gly 
    1265                 1270                 1275             


His Val  Glu Ile Val Lys Leu  Leu Leu Ala Gln Pro  Gly Cys Asn 
    1280                 1285                 1290             


Gly His  Leu Glu Asp Asn Asp  Gly Ser Thr Ala Leu  Ser Ile Ala 
    1295                 1300                 1305             


Leu Glu  Ala Gly His Lys Asp  Ile Ala Val Leu Leu  Tyr Ala His 
    1310                 1315                 1320             


Val Asn  Phe Ala Lys Ala Gln  Ser Pro Gly Thr Pro  Arg Leu Gly 
    1325                 1330                 1335             


Arg Lys  Thr Ser Pro Gly Pro  Thr His Arg Gly Ser  Phe Asp 
    1340                 1345                 1350         


<210>  5688
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KANK2__Homo_sapiens__NP_001129663

<400>  5688

Met Ala Gln Val Leu His Val Pro Ala Pro Phe Pro Gly Thr Pro Gly 
1               5                   10                  15      


Pro Ala Ser Pro Pro Ala Phe Pro Ala Lys Asp Pro Asp Pro Pro Tyr 
            20                  25                  30          


Ser Val Glu Thr Pro Tyr Gly Tyr Arg Leu Asp Leu Asp Phe Leu Lys 
        35                  40                  45              


Tyr Val Asp Asp Ile Glu Lys Gly His Thr Leu Arg Arg Val Ala Val 
    50                  55                  60                  


Gln Arg Arg Pro Arg Leu Ser Ser Leu Pro Arg Gly Pro Gly Ser Trp 
65                  70                  75                  80  


Trp Thr Ser Thr Glu Ser Leu Cys Ser Asn Ala Ser Gly Asp Ser Arg 
                85                  90                  95      


His Ser Ala Tyr Ser Tyr Cys Gly Arg Gly Phe Tyr Pro Gln Tyr Gly 
            100                 105                 110         


Ala Leu Glu Thr Arg Gly Gly Phe Asn Pro Arg Val Glu Arg Thr Leu 
        115                 120                 125             


Leu Asp Ala Arg Arg Arg Leu Glu Asp Gln Ala Ala Thr Pro Thr Gly 
    130                 135                 140                 


Leu Gly Ser Leu Thr Pro Ser Ala Ala Gly Ser Thr Ala Ser Leu Val 
145                 150                 155                 160 


Gly Val Gly Leu Pro Pro Pro Thr Pro Arg Ser Ser Gly Leu Ser Thr 
                165                 170                 175     


Pro Val Pro Pro Ser Ala Gly His Leu Ala His Val Arg Glu Gln Met 
            180                 185                 190         


Ala Gly Ala Leu Arg Lys Leu Arg Gln Leu Glu Glu Gln Val Lys Leu 
        195                 200                 205             


Ile Pro Val Leu Gln Val Lys Leu Ser Val Leu Gln Glu Glu Lys Arg 
    210                 215                 220                 


Gln Leu Thr Val Gln Leu Lys Ser Gln Lys Phe Leu Gly His Pro Thr 
225                 230                 235                 240 


Ala Gly Arg Gly Arg Ser Glu Leu Cys Leu Asp Leu Pro Asp Pro Pro 
                245                 250                 255     


Glu Asp Pro Val Ala Leu Glu Thr Arg Ser Val Gly Thr Trp Val Arg 
            260                 265                 270         


Glu Arg Asp Leu Gly Met Pro Asp Gly Glu Ala Ala Leu Ala Ala Lys 
        275                 280                 285             


Val Ala Val Leu Glu Thr Gln Leu Lys Lys Ala Leu Gln Glu Leu Gln 
    290                 295                 300                 


Ala Ala Gln Ala Arg Gln Ala Asp Pro Gln Pro Gln Ala Trp Pro Pro 
305                 310                 315                 320 


Pro Asp Ser Pro Val Arg Val Asp Thr Val Arg Val Val Glu Gly Pro 
                325                 330                 335     


Arg Glu Val Glu Val Val Ala Ser Thr Ala Ala Gly Ala Pro Ala Gln 
            340                 345                 350         


Arg Ala Gln Ser Leu Glu Pro Tyr Gly Thr Gly Leu Arg Ala Leu Ala 
        355                 360                 365             


Met Pro Gly Arg Pro Glu Ser Pro Pro Val Phe Arg Ser Gln Glu Val 
    370                 375                 380                 


Val Glu Thr Met Cys Pro Val Pro Ala Ala Ala Thr Ser Asn Val His 
385                 390                 395                 400 


Met Val Lys Lys Ile Ser Ile Thr Glu Arg Ser Cys Asp Gly Ala Ala 
                405                 410                 415     


Gly Leu Pro Glu Val Pro Ala Glu Ser Ser Ser Ser Pro Pro Gly Ser 
            420                 425                 430         


Glu Val Ala Ser Leu Thr Gln Pro Glu Lys Ser Thr Gly Arg Val Pro 
        435                 440                 445             


Thr Gln Glu Pro Thr His Arg Glu Pro Thr Arg Gln Ala Ala Ser Gln 
    450                 455                 460                 


Glu Ser Glu Glu Ala Gly Gly Thr Gly Gly Pro Pro Ala Gly Val Arg 
465                 470                 475                 480 


Ser Ile Met Lys Arg Lys Glu Glu Val Ala Asp Pro Thr Ala His Arg 
                485                 490                 495     


Arg Ser Leu Gln Phe Val Gly Val Asn Gly Gly Tyr Glu Ser Ser Ser 
            500                 505                 510         


Glu Asp Ser Ser Thr Ala Glu Asn Ile Ser Asp Asn Asp Ser Thr Glu 
        515                 520                 525             


Asn Glu Ala Pro Glu Pro Arg Glu Arg Val Pro Ser Val Ala Glu Ala 
    530                 535                 540                 


Pro Gln Leu Arg Pro Ala Gly Thr Ala Ala Ala Lys Thr Ser Arg Gln 
545                 550                 555                 560 


Glu Cys Gln Leu Ser Arg Glu Ser Gln His Ile Pro Thr Ala Glu Gly 
                565                 570                 575     


Ala Ser Gly Ser Asn Thr Glu Glu Glu Ile Arg Met Glu Leu Ser Pro 
            580                 585                 590         


Asp Leu Ile Ser Ala Cys Leu Ala Leu Glu Lys Tyr Leu Asp Asn Pro 
        595                 600                 605             


Asn Ala Leu Thr Glu Arg Glu Leu Lys Val Ala Tyr Thr Thr Val Leu 
    610                 615                 620                 


Gln Glu Trp Leu Arg Leu Ala Cys Arg Ser Asp Ala His Pro Glu Leu 
625                 630                 635                 640 


Val Arg Arg His Leu Val Thr Phe Arg Ala Met Ser Ala Arg Leu Leu 
                645                 650                 655     


Asp Tyr Val Val Asn Ile Ala Asp Ser Asn Gly Asn Thr Ala Leu His 
            660                 665                 670         


Tyr Ser Val Ser His Ala Asn Phe Pro Val Val Gln Gln Leu Leu Asp 
        675                 680                 685             


Ser Gly Val Cys Lys Val Asp Lys Gln Asn Arg Ala Gly Tyr Ser Pro 
    690                 695                 700                 


Ile Met Leu Thr Ala Leu Ala Thr Leu Lys Thr Gln Asp Asp Ile Glu 
705                 710                 715                 720 


Thr Val Leu Gln Leu Phe Arg Leu Gly Asn Ile Asn Ala Lys Ala Ser 
                725                 730                 735     


Gln Ala Gly Gln Thr Ala Leu Met Leu Ala Val Ser His Gly Arg Val 
            740                 745                 750         


Asp Val Val Lys Ala Leu Leu Ala Cys Glu Ala Asp Val Asn Val Gln 
        755                 760                 765             


Asp Asp Asp Gly Ser Thr Ala Leu Met Cys Ala Cys Glu His Gly His 
    770                 775                 780                 


Lys Glu Ile Ala Gly Leu Leu Leu Ala Val Pro Ser Cys Asp Ile Ser 
785                 790                 795                 800 


Leu Thr Asp Arg Asp Gly Ser Thr Ala Leu Met Val Ala Leu Asp Ala 
                805                 810                 815     


Gly Gln Ser Glu Ile Ala Ser Met Leu Tyr Ser Arg Met Asn Ile Lys 
            820                 825                 830         


Cys Ser Phe Ala Pro Met Ser Asp Asp Glu Ser Pro Thr Ser Ser Ser 
        835                 840                 845             


Ala Glu Glu 
    850     


<210>  5689
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KANK4__Homo_sapiens__NP_001307198

<400>  5689

Met Glu Lys Thr Asp Glu Ile Ser Pro Ser Thr Ser Leu Lys Ser Ile 
1               5                   10                  15      


Met Lys Lys Lys Asp Tyr Gly Phe Arg Ala Gly Gly Asn Gly Thr Lys 
            20                  25                  30          


Lys Asn Leu Gln Phe Val Gly Val Asn Gly Gly Tyr Glu Thr Thr Ser 
        35                  40                  45              


Ser Glu Glu Thr Ser Gly Glu Asp Ser Thr Pro Glu Asp Leu Ser Asp 
    50                  55                  60                  


Ser Glu Ala Glu Lys Lys Cys Asp Gly Pro Asp His Lys His Val Lys 
65                  70                  75                  80  


Asp Ala His Leu Thr Cys Glu Ala Gly Gln Gly Ile Pro Glu Gly Thr 
                85                  90                  95      


Cys His Ala Ala Gln Glu Ser Gly Pro Gly Glu Glu Val Pro His Ser 
            100                 105                 110         


Lys Ala Glu Arg Tyr Lys Pro Ser Glu Glu Phe Leu Asn Ala Cys Arg 
        115                 120                 125             


Ala Leu Ser Gln His Leu Pro Glu Thr Gly Thr Thr Thr Asp Gln Leu 
    130                 135                 140                 


Leu Arg Gln Ser Leu Asn Thr Ile Ser Gln Glu Trp Phe Arg Val Ser 
145                 150                 155                 160 


Ser Arg Lys Ser Ser Ser Pro Ala Val Val Ala Ser Tyr Leu His Glu 
                165                 170                 175     


Val Gln Pro His Ser Pro His Phe Leu Lys Leu Leu Val Asn Leu Ala 
            180                 185                 190         


Asp His Asn Gly Asn Thr Ala Leu His Tyr Ser Val Ser His Ser Asn 
        195                 200                 205             


Phe Ser Ile Val Lys Leu Leu Leu Glu Thr Gly Val Cys Asn Val Asp 
    210                 215                 220                 


His Gln Asn Lys Ala Gly Tyr Thr Ala Val Met Ile Thr Pro Leu Ala 
225                 230                 235                 240 


Ser Ala Glu Thr Asn Glu Asp Met Ala Val Val Trp Lys Leu Leu Arg 
                245                 250                 255     


Glu Gly Asn Val Asn Ile Gln Ala Thr Gln Gly Gly Gln Thr Ala Leu 
            260                 265                 270         


Met Leu Gly Val Ser His Asp Arg Glu Asp Met Val Gln Ala Leu Leu 
        275                 280                 285             


Ser Cys Gln Ala Asp Val Asn Leu Gln Asp His Asp Gly Ser Ser Ala 
    290                 295                 300                 


Leu Met Val Ala Cys His His Gly Asn Val Asp Leu Val Arg Leu Leu 
305                 310                 315                 320 


Leu Ala His Pro Ala Cys Asp Ser Ser Leu Thr Asp Lys Ala Gly Arg 
                325                 330                 335     


Thr Ala Leu Ser Ile Ala Leu Lys Ser Pro Thr His Met Glu Ile Ala 
            340                 345                 350         


Gly Leu Leu Arg Ala His Ala Glu Gln Gly Arg Ser Leu Gly Leu 
        355                 360                 365         


<210>  5690
<211>  1105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KANSL1__Homo_sapiens__XP_005275701

<400>  5690

Met Ala Ala Met Ala Pro Ala Leu Thr Asp Ala Ala Ala Glu Ala His 
1               5                   10                  15      


His Ile Arg Phe Lys Leu Ala Pro Pro Ser Ser Thr Leu Ser Pro Gly 
            20                  25                  30          


Ser Ala Glu Asn Asn Gly Asn Ala Asn Ile Leu Ile Ala Ala Asn Gly 
        35                  40                  45              


Thr Lys Arg Lys Ala Ile Ala Ala Glu Asp Pro Ser Leu Asp Phe Arg 
    50                  55                  60                  


Asn Asn Pro Thr Lys Glu Asp Leu Gly Lys Leu Gln Pro Leu Val Ala 
65                  70                  75                  80  


Ser Tyr Leu Cys Ser Asp Val Thr Ser Val Pro Ser Lys Glu Ser Leu 
                85                  90                  95      


Lys Leu Gln Gly Val Phe Ser Lys Gln Thr Val Leu Lys Ser His Pro 
            100                 105                 110         


Leu Leu Ser Gln Ser Tyr Glu Leu Arg Ala Glu Leu Leu Gly Arg Gln 
        115                 120                 125             


Pro Val Leu Glu Phe Ser Leu Glu Asn Leu Arg Thr Met Asn Thr Ser 
    130                 135                 140                 


Gly Gln Thr Ala Leu Pro Gln Ala Pro Val Asn Gly Leu Ala Lys Lys 
145                 150                 155                 160 


Leu Thr Lys Ser Ser Thr His Ser Asp His Asp Asn Ser Thr Ser Leu 
                165                 170                 175     


Asn Gly Gly Lys Arg Ala Leu Thr Ser Ser Ala Leu His Gly Gly Glu 
            180                 185                 190         


Met Gly Gly Ser Glu Ser Gly Asp Leu Lys Gly Gly Met Thr Asn Cys 
        195                 200                 205             


Thr Leu Pro His Arg Ser Leu Asp Val Glu His Thr Thr Leu Tyr Ser 
    210                 215                 220                 


Asn Asn Ser Thr Ala Asn Lys Ser Ser Val Asn Ser Met Glu Gln Pro 
225                 230                 235                 240 


Ala Leu Gln Gly Ser Ser Arg Leu Ser Pro Gly Thr Asp Ser Ser Ser 
                245                 250                 255     


Asn Leu Gly Gly Val Lys Leu Glu Gly Lys Lys Ser Pro Leu Ser Ser 
            260                 265                 270         


Ile Leu Phe Ser Ala Leu Asp Ser Asp Thr Arg Ile Thr Ala Leu Leu 
        275                 280                 285             


Arg Arg Gln Ala Asp Ile Glu Ser Arg Ala Arg Arg Leu Gln Lys Arg 
    290                 295                 300                 


Leu Gln Val Val Gln Ala Lys Gln Val Glu Arg His Ile Gln His Gln 
305                 310                 315                 320 


Leu Gly Gly Phe Leu Glu Lys Thr Leu Ser Lys Leu Pro Asn Leu Glu 
                325                 330                 335     


Ser Leu Arg Pro Arg Ser Gln Leu Met Leu Thr Arg Lys Ala Glu Ala 
            340                 345                 350         


Ala Leu Arg Lys Ala Ala Ser Glu Thr Thr Thr Ser Glu Gly Leu Ser 
        355                 360                 365             


Asn Phe Leu Lys Ser Asn Ser Ile Ser Glu Glu Leu Glu Arg Phe Thr 
    370                 375                 380                 


Ala Ser Gly Ile Ala Asn Leu Arg Cys Ser Glu Gln Ala Phe Asp Ser 
385                 390                 395                 400 


Asp Val Thr Asp Ser Ser Ser Gly Gly Glu Ser Asp Ile Glu Glu Glu 
                405                 410                 415     


Glu Leu Thr Arg Ala Asp Pro Glu Gln Arg His Val Pro Leu Arg Arg 
            420                 425                 430         


Arg Ser Glu Trp Lys Trp Ala Ala Asp Arg Ala Ala Ile Val Ser Arg 
        435                 440                 445             


Trp Asn Trp Leu Gln Ala His Val Ser Asp Leu Glu Tyr Arg Ile Arg 
    450                 455                 460                 


Gln Gln Thr Asp Ile Tyr Lys Gln Ile Arg Ala Asn Lys Gly Leu Ile 
465                 470                 475                 480 


Val Leu Gly Glu Val Pro Pro Pro Glu His Thr Thr Asp Leu Phe Leu 
                485                 490                 495     


Pro Leu Ser Ser Glu Val Lys Thr Asp His Gly Thr Asp Lys Leu Ile 
            500                 505                 510         


Glu Ser Val Ser Gln Pro Leu Glu Asn His Gly Ala Pro Ile Ile Gly 
        515                 520                 525             


His Ile Ser Glu Ser Leu Ser Thr Lys Ser Cys Gly Ala Leu Arg Pro 
    530                 535                 540                 


Val Asn Gly Val Ile Asn Thr Leu Gln Pro Val Leu Ala Asp His Ile 
545                 550                 555                 560 


Pro Gly Asp Ser Ser Asp Ala Glu Glu Gln Leu His Lys Lys Gln Arg 
                565                 570                 575     


Leu Asn Leu Val Ser Ser Ser Ser Asp Gly Thr Cys Val Ala Ala Arg 
            580                 585                 590         


Thr Arg Pro Val Leu Ser Cys Lys Lys Arg Arg Leu Val Arg Pro Asn 
        595                 600                 605             


Ser Ile Val Pro Leu Ser Lys Lys Val His Arg Asn Ser Thr Ile Arg 
    610                 615                 620                 


Pro Gly Cys Asp Val Asn Pro Ser Cys Ala Leu Cys Gly Ser Gly Ser 
625                 630                 635                 640 


Ile Asn Thr Met Pro Pro Glu Ile His Tyr Glu Ala Pro Leu Leu Glu 
                645                 650                 655     


Arg Leu Ser Gln Leu Asp Ser Cys Val His Pro Val Leu Ala Phe Pro 
            660                 665                 670         


Asp Asp Val Pro Thr Ser Leu His Phe Gln Ser Met Leu Lys Ser Gln 
        675                 680                 685             


Trp Gln Asn Lys Pro Phe Asp Lys Ile Lys Pro Pro Lys Lys Leu Ser 
    690                 695                 700                 


Leu Lys His Arg Ala Pro Met Pro Gly Ser Leu Pro Asp Pro Ala Arg 
705                 710                 715                 720 


Lys Asp Arg His Lys Leu Val Ser Ser Phe Leu Thr Thr Ala Lys Leu 
                725                 730                 735     


Ser His His Gln Thr Arg Pro Asp Arg Thr His Arg Gln His Leu Asp 
            740                 745                 750         


Asp Val Gly Ala Val Pro Met Val Glu Arg Val Thr Ala Pro Lys Ala 
        755                 760                 765             


Glu Arg Leu Leu Asn Pro Pro Pro Pro Val His Asp Pro Asn His Ser 
    770                 775                 780                 


Lys Met Arg Leu Arg Asp His Ser Ser Glu Arg Ser Glu Val Leu Lys 
785                 790                 795                 800 


His His Thr Asp Met Ser Ser Ser Ser Tyr Leu Ala Ala Thr His His 
                805                 810                 815     


Pro Pro His Ser Pro Leu Val Arg Gln Leu Ser Thr Ser Ser Asp Ser 
            820                 825                 830         


Pro Ala Pro Ala Ser Ser Ser Ser Gln Val Thr Ala Ser Thr Ser Gln 
        835                 840                 845             


Gln Pro Val Arg Arg Arg Arg Gly Glu Ser Ser Phe Asp Ile Asn Asn 
    850                 855                 860                 


Ile Val Ile Pro Met Ser Val Ala Ala Thr Thr Arg Val Glu Lys Leu 
865                 870                 875                 880 


Gln Tyr Lys Glu Ile Leu Thr Pro Ser Trp Arg Glu Val Asp Leu Gln 
                885                 890                 895     


Ser Leu Lys Gly Ser Pro Asp Glu Glu Asn Glu Glu Ile Glu Asp Leu 
            900                 905                 910         


Ser Asp Ala Ala Phe Ala Ala Leu His Ala Lys Cys Glu Glu Met Glu 
        915                 920                 925             


Arg Ala Arg Trp Leu Trp Thr Thr Ser Val Pro Pro Gln Arg Arg Gly 
    930                 935                 940                 


Ser Arg Ser Tyr Arg Ser Ser Asp Gly Arg Thr Thr Pro Gln Leu Gly 
945                 950                 955                 960 


Ser Ala Asn Pro Ser Thr Pro Gln Pro Ala Ser Pro Asp Val Ser Ser 
                965                 970                 975     


Ser His Ser Leu Ser Glu Tyr Ser His Gly Gln Ser Pro Arg Ser Pro 
            980                 985                 990         


Ile Ser Pro Glu Leu His Ser Ala  Pro Leu Thr Pro Val  Ala Arg Asp 
        995                 1000                 1005             


Thr Pro  Arg His Leu Ala Ser  Glu Asp Thr Arg Cys  Ser Thr Pro 
    1010                 1015                 1020             


Glu Leu  Gly Leu Asp Glu Gln  Ser Val Gln Pro Trp  Glu Arg Arg 
    1025                 1030                 1035             


Thr Phe  Pro Leu Ala His Ser  Pro Gln Ala Glu Cys  Glu Asp Gln 
    1040                 1045                 1050             


Leu Asp  Ala Gln Glu Arg Ala  Ala Arg Cys Thr Arg  Arg Thr Ser 
    1055                 1060                 1065             


Gly Ser  Lys Thr Gly Arg Glu  Thr Glu Ala Ala Pro  Thr Ser Pro 
    1070                 1075                 1080             


Pro Thr  Val Pro Leu Lys Ser  Arg His Leu Val Ala  Ala Ala Thr 
    1085                 1090                 1095             


Ala Gln  Arg Pro Thr His Arg  
    1100                 1105 


<210>  5691
<211>  878
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KANSL3__Homo_sapiens__NP_001108488

<400>  5691

Met Ala His Arg Gly Gly Glu Arg Asp Phe Gln Thr Ser Ala Arg Arg 
1               5                   10                  15      


Met Gly Thr Ser Leu Leu Phe Gln Leu Ser Val His Glu Arg Glu Leu 
            20                  25                  30          


Asp Leu Val Phe Leu Asp His Ser Tyr Ala Lys Pro Trp Ser Ala His 
        35                  40                  45              


Pro Asp Ala Ser Ser Ala Arg Pro Thr Arg Met Leu Phe Val Thr Pro 
    50                  55                  60                  


Arg Arg Gln His Glu Ser Thr Ile Glu Ser Asp Val Pro Ile Asp Val 
65                  70                  75                  80  


Glu Thr Val Thr Ser Thr Pro Met Pro Leu Tyr Asp Asn Gln Lys Ala 
                85                  90                  95      


Arg Ser Val Met Asn Glu Cys Glu Arg His Val Ile Phe Ala Arg Thr 
            100                 105                 110         


Asp Ala Asp Ala Pro Pro Pro Pro Glu Asp Trp Glu Glu His Val Asn 
        115                 120                 125             


Arg Thr Gly Trp Thr Met Ala Gln Asn Lys Leu Phe Asn Lys Ile Leu 
    130                 135                 140                 


Lys Ala Leu Gln Ser Asp Arg Leu Ala Arg Leu Ala Asn Glu Gly Ala 
145                 150                 155                 160 


Cys Asn Glu Pro Val Leu Arg Arg Val Ala Val Asp Lys Cys Ala Arg 
                165                 170                 175     


Arg Val Arg Gln Ala Leu Ala Ser Val Ser Trp Asp Thr Lys Leu Ile 
            180                 185                 190         


Gln Trp Leu His Thr Thr Leu Val Glu Thr Leu Ser Leu Pro Met Leu 
        195                 200                 205             


Ala Ala Tyr Leu Asp Ala Leu Gln Thr Leu Lys Gly Lys Ile Pro Thr 
    210                 215                 220                 


Leu Ile Asp Arg Met Leu Val Ser Ser Asn Thr Lys Thr Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Glu Ala Leu Ser Leu Leu Leu Lys Arg Pro Trp Asp Pro Ala 
                245                 250                 255     


Val Gly Val Leu Ser His Asn Lys Pro Ser Lys Leu Pro Gly Ser Pro 
            260                 265                 270         


Leu Ile Leu Ile Ala Ser Ser Gly Pro Ser Ser Ser Val Phe Pro Thr 
        275                 280                 285             


Ser Arg Arg His Arg Phe Trp Gln Ser Gln Leu Ser Cys Leu Gly Lys 
    290                 295                 300                 


Val Ile Pro Val Ala Thr His Leu Leu Asn Asn Gly Ser Gly Val Gly 
305                 310                 315                 320 


Val Leu Gln Cys Leu Glu His Met Ile Gly Ala Val Arg Ser Lys Val 
                325                 330                 335     


Leu Glu Ile His Ser His Phe Pro His Lys Pro Ile Ile Leu Ile Gly 
            340                 345                 350         


Trp Asn Thr Gly Ala Leu Val Ala Cys His Val Ser Val Met Glu Tyr 
        355                 360                 365             


Val Thr Ala Val Val Cys Leu Gly Phe Pro Leu Leu Thr Val Asp Gly 
    370                 375                 380                 


Pro Arg Gly Asp Val Asp Asp Pro Leu Leu Asp Met Lys Thr Pro Val 
385                 390                 395                 400 


Leu Phe Val Ile Gly Gln Asn Ser Leu Gln Cys His Pro Glu Ala Met 
                405                 410                 415     


Glu Asp Phe Arg Glu Lys Ile Arg Ala Glu Asn Ser Leu Val Val Val 
            420                 425                 430         


Gly Gly Ala Asp Asp Asn Leu Arg Ile Ser Lys Ala Lys Lys Lys Ser 
        435                 440                 445             


Glu Gly Leu Thr Gln Ser Met Val Asp Arg Cys Ile Gln Asp Glu Ile 
    450                 455                 460                 


Val Asp Phe Leu Thr Gly Val Leu Thr Arg Ala Glu Gly His Met Gly 
465                 470                 475                 480 


Ser Glu Pro Arg Asp Gln Asp Ala Glu Lys Lys Lys Lys Pro Arg Asp 
                485                 490                 495     


Val Ala Arg Arg Asp Leu Ala Phe Glu Val Pro Glu Arg Gly Ser Arg 
            500                 505                 510         


Pro Ala Ser Pro Ala Ala Lys Leu Pro Ala Ser Pro Ser Gly Ser Glu 
        515                 520                 525             


Asp Leu Ser Ser Val Ser Ser Ser Pro Thr Ser Ser Pro Lys Thr Lys 
    530                 535                 540                 


Val Thr Thr Val Thr Ser Ala Gln Lys Ser Ser Gln Ile Gly Ser Ser 
545                 550                 555                 560 


Gln Leu Leu Lys Arg His Val Gln Arg Thr Glu Ala Val Leu Thr His 
                565                 570                 575     


Lys Gln Ala Gln Val Pro Ile Ser Ser Glu Pro Pro Glu Glu Gly Glu 
            580                 585                 590         


Lys Glu Asp Leu Arg Val Gln Leu Lys Arg His His Pro Ser Ser Pro 
        595                 600                 605             


Leu Pro Gly Ser Lys Thr Ser Lys Arg Pro Lys Ile Lys Val Ser Leu 
    610                 615                 620                 


Ile Ser Gln Gly Asp Thr Ala Gly Gly Pro Cys Ala Pro Ser Gln Gly 
625                 630                 635                 640 


Ser Ala Pro Glu Ala Ala Gly Gly Lys Pro Ile Thr Met Thr Leu Gly 
                645                 650                 655     


Gln Ala Ser Ala Gly Ala Lys Glu Leu Thr Gly Leu Leu Thr Thr Ala 
            660                 665                 670         


Lys Ser Ser Ser Ser Glu Gly Gly Val Ser Ala Ser Pro Val Pro Ser 
        675                 680                 685             


Val Val Ser Ser Ser Thr Ala Pro Ser Ala Leu His Thr Leu Gln Ser 
    690                 695                 700                 


Arg Leu Val Ala Thr Ser Pro Gly Ser Ser Leu Pro Gly Ala Thr Ser 
705                 710                 715                 720 


Ala Ser Ser Leu Leu Gln Gly Leu Ser Phe Ser Leu Gln Asp Ile Ser 
                725                 730                 735     


Ser Lys Thr Ser Gly Leu Pro Ala Asn Pro Ser Pro Gly Pro Ala Pro 
            740                 745                 750         


Gln Ala Thr Ser Val Lys Leu Pro Thr Pro Met Gln Ser Leu Gly Ala 
        755                 760                 765             


Ile Thr Thr Gly Thr Ser Thr Ile Val Arg Thr Ile Pro Val Ala Thr 
    770                 775                 780                 


Thr Leu Ser Ser Leu Gly Ala Thr Pro Gly Gly Lys Pro Thr Ala Ile 
785                 790                 795                 800 


His Gln Leu Leu Thr Asn Gly Gly Leu Ala Lys Leu Ala Ser Ser Leu 
                805                 810                 815     


Pro Gly Leu Ala Gln Ile Ser Asn Gln Ala Ser Gly Leu Lys Val Pro 
            820                 825                 830         


Thr Thr Ile Thr Leu Thr Leu Arg Gly Gln Pro Ser Arg Ile Thr Thr 
        835                 840                 845             


Leu Ser Pro Met Gly Ser Gly Ala Ala Pro Ser Glu Glu Ser Ser Ser 
    850                 855                 860                 


Gln Val Leu Pro Ser Ser Ser Gln Arg Leu Pro Pro Ala Pro 
865                 870                 875             


<210>  5692
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KARS__Homo_sapiens__NP_001123561

<400>  5692

Met Leu Thr Gln Ala Ala Val Arg Leu Val Arg Gly Ser Leu Arg Lys 
1               5                   10                  15      


Thr Ser Trp Ala Glu Trp Gly His Arg Glu Leu Arg Leu Gly Gln Leu 
            20                  25                  30          


Ala Pro Phe Thr Ala Pro His Lys Asp Lys Ser Phe Ser Asp Gln Arg 
        35                  40                  45              


Ser Glu Leu Lys Arg Arg Leu Lys Ala Glu Lys Lys Val Ala Glu Lys 
    50                  55                  60                  


Glu Ala Lys Gln Lys Glu Leu Ser Glu Lys Gln Leu Ser Gln Ala Thr 
65                  70                  75                  80  


Ala Ala Ala Thr Asn His Thr Thr Asp Asn Gly Val Gly Pro Glu Glu 
                85                  90                  95      


Glu Ser Val Asp Pro Asn Gln Tyr Tyr Lys Ile Arg Ser Gln Ala Ile 
            100                 105                 110         


His Gln Leu Lys Val Asn Gly Glu Asp Pro Tyr Pro His Lys Phe His 
        115                 120                 125             


Val Asp Ile Ser Leu Thr Asp Phe Ile Gln Lys Tyr Ser His Leu Gln 
    130                 135                 140                 


Pro Gly Asp His Leu Thr Asp Ile Thr Leu Lys Val Ala Gly Arg Ile 
145                 150                 155                 160 


His Ala Lys Arg Ala Ser Gly Gly Lys Leu Ile Phe Tyr Asp Leu Arg 
                165                 170                 175     


Gly Glu Gly Val Lys Leu Gln Val Met Ala Asn Ser Arg Asn Tyr Lys 
            180                 185                 190         


Ser Glu Glu Glu Phe Ile His Ile Asn Asn Lys Leu Arg Arg Gly Asp 
        195                 200                 205             


Ile Ile Gly Val Gln Gly Asn Pro Gly Lys Thr Lys Lys Gly Glu Leu 
    210                 215                 220                 


Ser Ile Ile Pro Tyr Glu Ile Thr Leu Leu Ser Pro Cys Leu His Met 
225                 230                 235                 240 


Leu Pro His Leu His Phe Gly Leu Lys Asp Lys Glu Thr Arg Tyr Arg 
                245                 250                 255     


Gln Arg Tyr Leu Asp Leu Ile Leu Asn Asp Phe Val Arg Gln Lys Phe 
            260                 265                 270         


Ile Ile Arg Ser Lys Ile Ile Thr Tyr Ile Arg Ser Phe Leu Asp Glu 
        275                 280                 285             


Leu Gly Phe Leu Glu Ile Glu Thr Pro Met Met Asn Ile Ile Pro Gly 
    290                 295                 300                 


Gly Ala Val Ala Lys Pro Phe Ile Thr Tyr His Asn Glu Leu Asp Met 
305                 310                 315                 320 


Asn Leu Tyr Met Arg Ile Ala Pro Glu Leu Tyr His Lys Met Leu Val 
                325                 330                 335     


Val Gly Gly Ile Asp Arg Val Tyr Glu Ile Gly Arg Gln Phe Arg Asn 
            340                 345                 350         


Glu Gly Ile Asp Leu Thr His Asn Pro Glu Phe Thr Thr Cys Glu Phe 
        355                 360                 365             


Tyr Met Ala Tyr Ala Asp Tyr His Asp Leu Met Glu Ile Thr Glu Lys 
    370                 375                 380                 


Met Val Ser Gly Met Val Lys His Ile Thr Gly Ser Tyr Lys Val Thr 
385                 390                 395                 400 


Tyr His Pro Asp Gly Pro Glu Gly Gln Ala Tyr Asp Val Asp Phe Thr 
                405                 410                 415     


Pro Pro Phe Arg Arg Ile Asn Met Val Glu Glu Leu Glu Lys Ala Leu 
            420                 425                 430         


Gly Met Lys Leu Pro Glu Thr Asn Leu Phe Glu Thr Glu Glu Thr Arg 
        435                 440                 445             


Lys Ile Leu Asp Asp Ile Cys Val Ala Lys Ala Val Glu Cys Pro Pro 
    450                 455                 460                 


Pro Arg Thr Thr Ala Arg Leu Leu Asp Lys Leu Val Gly Glu Phe Leu 
465                 470                 475                 480 


Glu Val Thr Cys Ile Asn Pro Thr Phe Ile Cys Asp His Pro Gln Ile 
                485                 490                 495     


Met Ser Pro Leu Ala Lys Trp His Arg Ser Lys Glu Gly Leu Thr Glu 
            500                 505                 510         


Arg Phe Glu Leu Phe Val Met Lys Lys Glu Ile Cys Asn Ala Tyr Thr 
        515                 520                 525             


Glu Leu Asn Asp Pro Met Arg Gln Arg Gln Leu Phe Glu Glu Gln Ala 
    530                 535                 540                 


Lys Ala Lys Ala Ala Gly Asp Asp Glu Ala Met Phe Ile Asp Glu Asn 
545                 550                 555                 560 


Phe Cys Thr Ala Leu Glu Tyr Gly Leu Pro Pro Thr Ala Gly Trp Gly 
                565                 570                 575     


Met Gly Ile Asp Arg Val Ala Met Phe Leu Thr Asp Ser Asn Asn Ile 
            580                 585                 590         


Lys Glu Val Leu Leu Phe Pro Ala Met Lys Pro Glu Asp Lys Lys Glu 
        595                 600                 605             


Asn Val Ala Thr Thr Asp Thr Leu Glu Ser Thr Thr Val Gly Thr Ser 
    610                 615                 620                 


Val 
625 


<210>  5693
<211>  837
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAT2A__Homo_sapiens__NP_066564

<400>  5693

Met Ala Glu Pro Ser Gln Ala Pro Thr Pro Ala Pro Ala Ala Gln Pro 
1               5                   10                  15      


Arg Pro Leu Gln Ser Pro Ala Pro Ala Pro Thr Pro Thr Pro Ala Pro 
            20                  25                  30          


Ser Pro Ala Ser Ala Pro Ile Pro Thr Pro Thr Pro Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ala Ala Ala Pro Ala Gly Ser Thr Gly Thr Gly Gly Pro Gly 
    50                  55                  60                  


Val Gly Ser Gly Gly Ala Gly Ser Gly Gly Asp Pro Ala Arg Pro Gly 
65                  70                  75                  80  


Leu Ser Gln Gln Gln Arg Ala Ser Gln Arg Lys Ala Gln Val Arg Gly 
                85                  90                  95      


Leu Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val Phe Ser Ala Cys 
            100                 105                 110         


Lys Ala Asn Glu Thr Cys Lys Cys Asn Gly Trp Lys Asn Pro Lys Pro 
        115                 120                 125             


Pro Thr Ala Pro Arg Met Asp Leu Gln Gln Pro Ala Ala Asn Leu Ser 
    130                 135                 140                 


Glu Leu Cys Arg Ser Cys Glu His Pro Leu Ala Asp His Val Ser His 
145                 150                 155                 160 


Leu Glu Asn Val Ser Glu Asp Glu Ile Asn Arg Leu Leu Gly Met Val 
                165                 170                 175     


Val Asp Val Glu Asn Leu Phe Met Ser Val His Lys Glu Glu Asp Thr 
            180                 185                 190         


Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys Leu Leu Arg Lys Cys 
        195                 200                 205             


Ile Leu Gln Met Thr Arg Pro Val Val Glu Gly Ser Leu Gly Ser Pro 
    210                 215                 220                 


Pro Phe Glu Lys Pro Asn Ile Glu Gln Gly Val Leu Asn Phe Val Gln 
225                 230                 235                 240 


Tyr Lys Phe Ser His Leu Ala Pro Arg Glu Arg Gln Thr Met Phe Glu 
                245                 250                 255     


Leu Ser Lys Met Phe Leu Leu Cys Leu Asn Tyr Trp Lys Leu Glu Thr 
            260                 265                 270         


Pro Ala Gln Phe Arg Gln Arg Ser Gln Ala Glu Asp Val Ala Thr Tyr 
        275                 280                 285             


Lys Val Asn Tyr Thr Arg Trp Leu Cys Tyr Cys His Val Pro Gln Ser 
    290                 295                 300                 


Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr His Val Phe Gly Arg Ser 
305                 310                 315                 320 


Leu Leu Arg Ser Ile Phe Thr Val Thr Arg Arg Gln Leu Leu Glu Lys 
                325                 330                 335     


Phe Arg Val Glu Lys Asp Lys Leu Val Pro Glu Lys Arg Thr Leu Ile 
            340                 345                 350         


Leu Thr His Phe Pro Lys Phe Leu Ser Met Leu Glu Glu Glu Ile Tyr 
        355                 360                 365             


Gly Ala Asn Ser Pro Ile Trp Glu Ser Gly Phe Thr Met Pro Pro Ser 
    370                 375                 380                 


Glu Gly Thr Gln Leu Val Pro Arg Pro Ala Ser Val Ser Ala Ala Val 
385                 390                 395                 400 


Val Pro Ser Thr Pro Ile Phe Ser Pro Ser Met Gly Gly Gly Ser Asn 
                405                 410                 415     


Ser Ser Leu Ser Leu Asp Ser Ala Gly Ala Glu Pro Met Pro Gly Glu 
            420                 425                 430         


Lys Arg Thr Leu Pro Glu Asn Leu Thr Leu Glu Asp Ala Lys Arg Leu 
        435                 440                 445             


Arg Val Met Gly Asp Ile Pro Met Glu Leu Val Asn Glu Val Met Leu 
    450                 455                 460                 


Thr Ile Thr Asp Pro Ala Ala Met Leu Gly Pro Glu Thr Ser Leu Leu 
465                 470                 475                 480 


Ser Ala Asn Ala Ala Arg Asp Glu Thr Ala Arg Leu Glu Glu Arg Arg 
                485                 490                 495     


Gly Ile Ile Glu Phe His Val Ile Gly Asn Ser Leu Thr Pro Lys Ala 
            500                 505                 510         


Asn Arg Arg Val Leu Leu Trp Leu Val Gly Leu Gln Asn Val Phe Ser 
        515                 520                 525             


His Gln Leu Pro Arg Met Pro Lys Glu Tyr Ile Ala Arg Leu Val Phe 
    530                 535                 540                 


Asp Pro Lys His Lys Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile 
545                 550                 555                 560 


Gly Gly Ile Cys Phe Arg Met Phe Pro Thr Gln Gly Phe Thr Glu Ile 
                565                 570                 575     


Val Phe Cys Ala Val Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr 
            580                 585                 590         


His Leu Met Asn His Leu Lys Glu Tyr His Ile Lys His Asn Ile Leu 
        595                 600                 605             


Tyr Phe Leu Thr Tyr Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys 
    610                 615                 620                 


Gln Gly Phe Ser Lys Asp Ile Lys Val Pro Lys Ser Arg Tyr Leu Gly 
625                 630                 635                 640 


Tyr Ile Lys Asp Tyr Glu Gly Ala Thr Leu Met Glu Cys Glu Leu Asn 
                645                 650                 655     


Pro Arg Ile Pro Tyr Thr Glu Leu Ser His Ile Ile Lys Lys Gln Lys 
            660                 665                 670         


Glu Ile Ile Lys Lys Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys 
        675                 680                 685             


Val Tyr Pro Gly Leu Ser Cys Phe Lys Glu Gly Val Arg Gln Ile Pro 
    690                 695                 700                 


Val Glu Ser Val Pro Gly Ile Arg Glu Thr Gly Trp Lys Pro Leu Gly 
705                 710                 715                 720 


Lys Glu Lys Gly Lys Glu Leu Lys Asp Pro Asp Gln Leu Tyr Thr Thr 
                725                 730                 735     


Leu Lys Asn Leu Leu Ala Gln Ile Lys Ser His Pro Ser Ala Trp Pro 
            740                 745                 750         


Phe Met Glu Pro Val Lys Lys Ser Glu Ala Pro Asp Tyr Tyr Glu Val 
        755                 760                 765             


Ile Arg Phe Pro Ile Asp Leu Lys Thr Met Thr Glu Arg Leu Arg Ser 
    770                 775                 780                 


Arg Tyr Tyr Val Thr Arg Lys Leu Phe Val Ala Asp Leu Gln Arg Val 
785                 790                 795                 800 


Ile Ala Asn Cys Arg Glu Tyr Asn Pro Pro Asp Ser Glu Tyr Cys Arg 
                805                 810                 815     


Cys Ala Ser Ala Leu Glu Lys Phe Phe Tyr Phe Lys Leu Lys Glu Gly 
            820                 825                 830         


Gly Leu Ile Asp Lys 
        835         


<210>  5694
<211>  832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAT2B__Homo_sapiens__NP_003875

<400>  5694

Met Ser Glu Ala Gly Gly Ala Gly Pro Gly Gly Cys Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Pro Gly Ala Leu Pro Pro Gln Pro Ala Ala Leu 
            20                  25                  30          


Pro Pro Ala Pro Pro Gln Gly Ser Pro Cys Ala Ala Ala Ala Gly Gly 
        35                  40                  45              


Ser Gly Ala Cys Gly Pro Ala Thr Ala Val Ala Ala Ala Gly Thr Ala 
    50                  55                  60                  


Glu Gly Pro Gly Gly Gly Gly Ser Ala Arg Ile Ala Val Lys Lys Ala 
65                  70                  75                  80  


Gln Leu Arg Ser Ala Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val 
                85                  90                  95      


Tyr Ser Ala Cys Lys Ala Glu Glu Ser Cys Lys Cys Asn Gly Trp Lys 
            100                 105                 110         


Asn Pro Asn Pro Ser Pro Thr Pro Pro Arg Ala Asp Leu Gln Gln Ile 
        115                 120                 125             


Ile Val Ser Leu Thr Glu Ser Cys Arg Ser Cys Ser His Ala Leu Ala 
    130                 135                 140                 


Ala His Val Ser His Leu Glu Asn Val Ser Glu Glu Glu Met Asn Arg 
145                 150                 155                 160 


Leu Leu Gly Ile Val Leu Asp Val Glu Tyr Leu Phe Thr Cys Val His 
                165                 170                 175     


Lys Glu Glu Asp Ala Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys 
            180                 185                 190         


Leu Leu Arg Lys Ser Ile Leu Gln Arg Gly Lys Pro Val Val Glu Gly 
        195                 200                 205             


Ser Leu Glu Lys Lys Pro Pro Phe Glu Lys Pro Ser Ile Glu Gln Gly 
    210                 215                 220                 


Val Asn Asn Phe Val Gln Tyr Lys Phe Ser His Leu Pro Ala Lys Glu 
225                 230                 235                 240 


Arg Gln Thr Ile Val Glu Leu Ala Lys Met Phe Leu Asn Arg Ile Asn 
                245                 250                 255     


Tyr Trp His Leu Glu Ala Pro Ser Gln Arg Arg Leu Arg Ser Pro Asn 
            260                 265                 270         


Asp Asp Ile Ser Gly Tyr Lys Glu Asn Tyr Thr Arg Trp Leu Cys Tyr 
        275                 280                 285             


Cys Asn Val Pro Gln Phe Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr 
    290                 295                 300                 


Gln Val Phe Gly Arg Thr Leu Leu Arg Ser Val Phe Thr Val Met Arg 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Gln Ala Arg Gln Glu Lys Asp Lys Leu Pro Leu 
                325                 330                 335     


Glu Lys Arg Thr Leu Ile Leu Thr His Phe Pro Lys Phe Leu Ser Met 
            340                 345                 350         


Leu Glu Glu Glu Val Tyr Ser Gln Asn Ser Pro Ile Trp Asp Gln Asp 
        355                 360                 365             


Phe Leu Ser Ala Ser Ser Arg Thr Ser Gln Leu Gly Ile Gln Thr Val 
    370                 375                 380                 


Ile Asn Pro Pro Pro Val Ala Gly Thr Ile Ser Tyr Asn Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Leu Glu Gln Pro Asn Ala Gly Ser Ser Ser Pro Ala Cys Lys 
                405                 410                 415     


Ala Ser Ser Gly Leu Glu Ala Asn Pro Gly Glu Lys Arg Lys Met Thr 
            420                 425                 430         


Asp Ser His Val Leu Glu Glu Ala Lys Lys Pro Arg Val Met Gly Asp 
        435                 440                 445             


Ile Pro Met Glu Leu Ile Asn Glu Val Met Ser Thr Ile Thr Asp Pro 
    450                 455                 460                 


Ala Ala Met Leu Gly Pro Glu Thr Asn Phe Leu Ser Ala His Ser Ala 
465                 470                 475                 480 


Arg Asp Glu Ala Ala Arg Leu Glu Glu Arg Arg Gly Val Ile Glu Phe 
                485                 490                 495     


His Val Val Gly Asn Ser Leu Asn Gln Lys Pro Asn Lys Lys Ile Leu 
            500                 505                 510         


Met Trp Leu Val Gly Leu Gln Asn Val Phe Ser His Gln Leu Pro Arg 
        515                 520                 525             


Met Pro Lys Glu Tyr Ile Thr Arg Leu Val Phe Asp Pro Lys His Lys 
    530                 535                 540                 


Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile Gly Gly Ile Cys Phe 
545                 550                 555                 560 


Arg Met Phe Pro Ser Gln Gly Phe Thr Glu Ile Val Phe Cys Ala Val 
                565                 570                 575     


Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr His Leu Met Asn His 
            580                 585                 590         


Leu Lys Glu Tyr His Ile Lys His Asp Ile Leu Asn Phe Leu Thr Tyr 
        595                 600                 605             


Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys Gln Gly Phe Ser Lys 
    610                 615                 620                 


Glu Ile Lys Ile Pro Lys Thr Lys Tyr Val Gly Tyr Ile Lys Asp Tyr 
625                 630                 635                 640 


Glu Gly Ala Thr Leu Met Gly Cys Glu Leu Asn Pro Arg Ile Pro Tyr 
                645                 650                 655     


Thr Glu Phe Ser Val Ile Ile Lys Lys Gln Lys Glu Ile Ile Lys Lys 
            660                 665                 670         


Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys Val Tyr Pro Gly Leu 
        675                 680                 685             


Ser Cys Phe Lys Asp Gly Val Arg Gln Ile Pro Ile Glu Ser Ile Pro 
    690                 695                 700                 


Gly Ile Arg Glu Thr Gly Trp Lys Pro Ser Gly Lys Glu Lys Ser Lys 
705                 710                 715                 720 


Glu Pro Arg Asp Pro Asp Gln Leu Tyr Ser Thr Leu Lys Ser Ile Leu 
                725                 730                 735     


Gln Gln Val Lys Ser His Gln Ser Ala Trp Pro Phe Met Glu Pro Val 
            740                 745                 750         


Lys Arg Thr Glu Ala Pro Gly Tyr Tyr Glu Val Ile Arg Phe Pro Met 
        755                 760                 765             


Asp Leu Lys Thr Met Ser Glu Arg Leu Lys Asn Arg Tyr Tyr Val Ser 
    770                 775                 780                 


Lys Lys Leu Phe Met Ala Asp Leu Gln Arg Val Phe Thr Asn Cys Lys 
785                 790                 795                 800 


Glu Tyr Asn Pro Pro Glu Ser Glu Tyr Tyr Lys Cys Ala Asn Ile Leu 
                805                 810                 815     


Glu Lys Phe Phe Phe Ser Lys Ile Lys Glu Ala Gly Leu Ile Asp Lys 
            820                 825                 830         


<210>  5695
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAT5__Homo_sapiens__NP_001193762

<400>  5695

Met Ala Glu Val Val Ser Pro Val Pro Gly Ala Gly Arg Arg Glu Pro 
1               5                   10                  15      


Gly Glu Val Gly Arg Ala Arg Gly Pro Pro Val Ala Asp Pro Gly Val 
            20                  25                  30          


Ala Leu Ser Pro Gln Gly Glu Ile Ile Glu Gly Cys Arg Leu Pro Val 
        35                  40                  45              


Leu Arg Arg Asn Gln Asp Asn Glu Asp Glu Trp Pro Leu Ala Glu Ile 
    50                  55                  60                  


Leu Ser Val Lys Asp Ile Ser Gly Arg Lys Leu Phe Tyr Val His Tyr 
65                  70                  75                  80  


Ile Asp Phe Asn Lys Arg Leu Asp Glu Trp Val Thr His Glu Arg Leu 
                85                  90                  95      


Asp Leu Lys Lys Ile Gln Phe Pro Lys Lys Glu Ala Lys Thr Pro Thr 
            100                 105                 110         


Lys Asn Gly Leu Pro Gly Ser Arg Pro Gly Ser Pro Glu Arg Glu Val 
        115                 120                 125             


Lys Arg Lys Val Glu Val Val Ser Pro Ala Thr Pro Val Pro Ser Glu 
    130                 135                 140                 


Thr Ala Pro Ala Ser Val Phe Pro Gln Asn Gly Ala Ala Arg Arg Ala 
145                 150                 155                 160 


Val Ala Ala Gln Pro Gly Arg Lys Arg Lys Ser Asn Cys Leu Gly Thr 
                165                 170                 175     


Asp Glu Asp Ser Gln Asp Ser Ser Asp Gly Ile Pro Ser Ala Pro Arg 
            180                 185                 190         


Met Thr Gly Ser Leu Val Ser Asp Arg Ser His Asp Asp Ile Val Thr 
        195                 200                 205             


Arg Met Lys Asn Ile Glu Cys Ile Glu Leu Gly Arg His Arg Leu Lys 
    210                 215                 220                 


Pro Trp Tyr Phe Ser Pro Tyr Pro Gln Glu Leu Thr Thr Leu Pro Val 
225                 230                 235                 240 


Leu Tyr Leu Cys Glu Phe Cys Leu Lys Tyr Gly Arg Ser Leu Lys Cys 
                245                 250                 255     


Leu Gln Arg His Leu Thr Lys Cys Asp Leu Arg His Pro Pro Gly Asn 
            260                 265                 270         


Glu Ile Tyr Arg Lys Gly Thr Ile Ser Phe Phe Glu Ile Asp Gly Arg 
        275                 280                 285             


Lys Asn Lys Ser Tyr Ser Gln Asn Leu Cys Leu Leu Ala Lys Cys Phe 
    290                 295                 300                 


Leu Asp His Lys Thr Leu Tyr Tyr Asp Thr Asp Pro Phe Leu Phe Tyr 
305                 310                 315                 320 


Val Met Thr Glu Tyr Asp Cys Lys Gly Phe His Ile Val Gly Tyr Phe 
                325                 330                 335     


Ser Lys Glu Lys Glu Ser Thr Glu Asp Tyr Asn Val Ala Cys Ile Leu 
            340                 345                 350         


Thr Leu Pro Pro Tyr Gln Arg Arg Gly Tyr Gly Lys Leu Leu Ile Glu 
        355                 360                 365             


Phe Ser Tyr Glu Leu Ser Lys Val Glu Gly Lys Thr Gly Thr Pro Glu 
    370                 375                 380                 


Lys Pro Leu Ser Asp Leu Gly Leu Leu Ser Tyr Arg Ser Tyr Trp Ser 
385                 390                 395                 400 


Gln Thr Ile Leu Glu Ile Leu Met Gly Leu Lys Ser Glu Ser Gly Glu 
                405                 410                 415     


Arg Pro Gln Ile Thr Ile Asn Glu Ile Ser Glu Ile Thr Ser Ile Lys 
            420                 425                 430         


Lys Glu Asp Val Ile Ser Thr Leu Gln Tyr Leu Asn Leu Ile Asn Tyr 
        435                 440                 445             


Tyr Lys Gly Gln Tyr Ile Leu Thr Leu Ser Glu Asp Ile Val Asp Gly 
    450                 455                 460                 


His Glu Arg Ala Met Leu Lys Arg Leu Leu Arg Ile Asp Ser Lys Cys 
465                 470                 475                 480 


Leu His Phe Thr Pro Lys Asp Trp Ser Lys Arg Gly Lys Trp 
                485                 490                 


<210>  5696
<211>  2004
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAT6A__Homo_sapiens__NP_006757

<400>  5696

Met Val Lys Leu Ala Asn Pro Leu Tyr Thr Glu Trp Ile Leu Glu Ala 
1               5                   10                  15      


Ile Lys Lys Val Lys Lys Gln Lys Gln Arg Pro Ser Glu Glu Arg Ile 
            20                  25                  30          


Cys Asn Ala Val Ser Ser Ser His Gly Leu Asp Arg Lys Thr Val Leu 
        35                  40                  45              


Glu Gln Leu Glu Leu Ser Val Lys Asp Gly Thr Ile Leu Lys Val Ser 
    50                  55                  60                  


Asn Lys Gly Leu Asn Ser Tyr Lys Asp Pro Asp Asn Pro Gly Arg Ile 
65                  70                  75                  80  


Ala Leu Pro Lys Pro Arg Asn His Gly Lys Leu Asp Asn Lys Gln Asn 
                85                  90                  95      


Val Asp Trp Asn Lys Leu Ile Lys Arg Ala Val Glu Gly Leu Ala Glu 
            100                 105                 110         


Ser Gly Gly Ser Thr Leu Lys Ser Ile Glu Arg Phe Leu Lys Gly Gln 
        115                 120                 125             


Lys Asp Val Ser Ala Leu Phe Gly Gly Ser Ala Ala Ser Gly Phe His 
    130                 135                 140                 


Gln Gln Leu Arg Leu Ala Ile Lys Arg Ala Ile Gly His Gly Arg Leu 
145                 150                 155                 160 


Leu Lys Asp Gly Pro Leu Tyr Arg Leu Asn Thr Lys Ala Thr Asn Val 
                165                 170                 175     


Asp Gly Lys Glu Ser Cys Glu Ser Leu Ser Cys Leu Pro Pro Val Ser 
            180                 185                 190         


Leu Leu Pro His Glu Lys Asp Lys Pro Val Ala Glu Pro Ile Pro Ile 
        195                 200                 205             


Cys Ser Phe Cys Leu Gly Thr Lys Glu Gln Asn Arg Glu Lys Lys Pro 
    210                 215                 220                 


Glu Glu Leu Ile Ser Cys Ala Asp Cys Gly Asn Ser Gly His Pro Ser 
225                 230                 235                 240 


Cys Leu Lys Phe Ser Pro Glu Leu Thr Val Arg Val Lys Ala Leu Arg 
                245                 250                 255     


Trp Gln Cys Ile Glu Cys Lys Thr Cys Ser Ser Cys Arg Asp Gln Gly 
            260                 265                 270         


Lys Asn Ala Asp Asn Met Leu Phe Cys Asp Ser Cys Asp Arg Gly Phe 
        275                 280                 285             


His Met Glu Cys Cys Asp Pro Pro Leu Thr Arg Met Pro Lys Gly Met 
    290                 295                 300                 


Trp Ile Cys Gln Ile Cys Arg Pro Arg Lys Lys Gly Arg Lys Leu Leu 
305                 310                 315                 320 


Gln Lys Lys Ala Ala Gln Ile Lys Arg Arg Tyr Thr Asn Pro Ile Gly 
                325                 330                 335     


Arg Pro Lys Asn Arg Leu Lys Lys Gln Asn Thr Val Ser Lys Gly Pro 
            340                 345                 350         


Phe Ser Lys Val Arg Thr Gly Pro Gly Arg Gly Arg Lys Arg Lys Ile 
        355                 360                 365             


Thr Leu Ser Ser Gln Ser Ala Ser Ser Ser Ser Glu Glu Gly Tyr Leu 
    370                 375                 380                 


Glu Arg Ile Asp Gly Leu Asp Phe Cys Arg Asp Ser Asn Val Ser Leu 
385                 390                 395                 400 


Lys Phe Asn Lys Lys Thr Lys Gly Leu Ile Asp Gly Leu Thr Lys Phe 
                405                 410                 415     


Phe Thr Pro Ser Pro Asp Gly Arg Lys Ala Arg Gly Glu Val Val Asp 
            420                 425                 430         


Tyr Ser Glu Gln Tyr Arg Ile Arg Lys Arg Gly Asn Arg Lys Ser Ser 
        435                 440                 445             


Thr Ser Asp Trp Pro Thr Asp Asn Gln Asp Gly Trp Asp Gly Lys Gln 
    450                 455                 460                 


Glu Asn Glu Glu Arg Leu Phe Gly Ser Gln Glu Ile Met Thr Glu Lys 
465                 470                 475                 480 


Asp Met Glu Leu Phe Arg Asp Ile Gln Glu Gln Ala Leu Gln Lys Val 
                485                 490                 495     


Gly Val Thr Gly Pro Pro Asp Pro Gln Val Arg Cys Pro Ser Val Ile 
            500                 505                 510         


Glu Phe Gly Lys Tyr Glu Ile His Thr Trp Tyr Ser Ser Pro Tyr Pro 
        515                 520                 525             


Gln Glu Tyr Ser Arg Leu Pro Lys Leu Tyr Leu Cys Glu Phe Cys Leu 
    530                 535                 540                 


Lys Tyr Met Lys Ser Arg Thr Ile Leu Gln Gln His Met Lys Lys Cys 
545                 550                 555                 560 


Gly Trp Phe His Pro Pro Ala Asn Glu Ile Tyr Arg Lys Asn Asn Ile 
                565                 570                 575     


Ser Val Phe Glu Val Asp Gly Asn Val Ser Thr Ile Tyr Cys Gln Asn 
            580                 585                 590         


Leu Cys Leu Leu Ala Lys Leu Phe Leu Asp His Lys Thr Leu Tyr Tyr 
        595                 600                 605             


Asp Val Glu Pro Phe Leu Phe Tyr Val Leu Thr Gln Asn Asp Val Lys 
    610                 615                 620                 


Gly Cys His Leu Val Gly Tyr Phe Ser Lys Glu Lys His Cys Gln Gln 
625                 630                 635                 640 


Lys Tyr Asn Val Ser Cys Ile Met Ile Leu Pro Gln Tyr Gln Arg Lys 
                645                 650                 655     


Gly Tyr Gly Arg Phe Leu Ile Asp Phe Ser Tyr Leu Leu Ser Lys Arg 
            660                 665                 670         


Glu Gly Gln Ala Gly Ser Pro Glu Lys Pro Leu Ser Asp Leu Gly Arg 
        675                 680                 685             


Leu Ser Tyr Met Ala Tyr Trp Lys Ser Val Ile Leu Glu Cys Leu Tyr 
    690                 695                 700                 


His Gln Asn Asp Lys Gln Ile Ser Ile Lys Lys Leu Ser Lys Leu Thr 
705                 710                 715                 720 


Gly Ile Cys Pro Gln Asp Ile Thr Ser Thr Leu His His Leu Arg Met 
                725                 730                 735     


Leu Asp Phe Arg Ser Asp Gln Phe Val Ile Ile Arg Arg Glu Lys Leu 
            740                 745                 750         


Ile Gln Asp His Met Ala Lys Leu Gln Leu Asn Leu Arg Pro Val Asp 
        755                 760                 765             


Val Asp Pro Glu Cys Leu Arg Trp Thr Pro Val Ile Val Ser Asn Ser 
    770                 775                 780                 


Val Val Ser Glu Glu Glu Glu Glu Glu Ala Glu Glu Gly Glu Asn Glu 
785                 790                 795                 800 


Glu Pro Gln Cys Gln Glu Arg Glu Leu Glu Ile Ser Val Gly Lys Ser 
                805                 810                 815     


Val Ser His Glu Asn Lys Glu Gln Asp Ser Tyr Ser Val Glu Ser Glu 
            820                 825                 830         


Lys Lys Pro Glu Val Met Ala Pro Val Ser Ser Thr Arg Leu Ser Lys 
        835                 840                 845             


Gln Val Leu Pro His Asp Ser Leu Pro Ala Asn Ser Gln Pro Ser Arg 
    850                 855                 860                 


Arg Gly Arg Trp Gly Arg Lys Asn Arg Lys Thr Gln Glu Arg Phe Gly 
865                 870                 875                 880 


Asp Lys Asp Ser Lys Leu Leu Leu Glu Glu Thr Ser Ser Ala Pro Gln 
                885                 890                 895     


Glu Gln Tyr Gly Glu Cys Gly Glu Lys Ser Glu Ala Thr Gln Glu Gln 
            900                 905                 910         


Tyr Thr Glu Ser Glu Glu Gln Leu Val Ala Ser Glu Glu Gln Pro Ser 
        915                 920                 925             


Gln Asp Gly Lys Pro Asp Leu Pro Lys Arg Arg Leu Ser Glu Gly Val 
    930                 935                 940                 


Glu Pro Trp Arg Gly Gln Leu Lys Lys Ser Pro Glu Ala Leu Lys Cys 
945                 950                 955                 960 


Arg Leu Thr Glu Gly Ser Glu Arg Leu Pro Arg Arg Tyr Ser Glu Gly 
                965                 970                 975     


Asp Arg Ala Val Leu Arg Gly Phe Ser Glu Ser Ser Glu Glu Glu Glu 
            980                 985                 990         


Glu Pro Glu Ser Pro Arg Ser Ser  Ser Pro Pro Ile Leu  Thr Lys Pro 
        995                 1000                 1005             


Thr Leu  Lys Arg Lys Lys Pro  Phe Leu His Arg Arg  Arg Arg Val 
    1010                 1015                 1020             


Arg Lys  Arg Lys His His Asn  Ser Ser Val Val Thr  Glu Thr Ile 
    1025                 1030                 1035             


Ser Glu  Thr Thr Glu Val Leu  Asp Glu Pro Phe Glu  Asp Ser Asp 
    1040                 1045                 1050             


Ser Glu  Arg Pro Met Pro Arg  Leu Glu Pro Thr Phe  Glu Ile Asp 
    1055                 1060                 1065             


Glu Glu  Glu Glu Glu Glu Asp  Glu Asn Glu Leu Phe  Pro Arg Glu 
    1070                 1075                 1080             


Tyr Phe  Arg Arg Leu Ser Ser  Gln Asp Val Leu Arg  Cys Gln Ser 
    1085                 1090                 1095             


Ser Ser  Lys Arg Lys Ser Lys  Asp Glu Glu Glu Asp  Glu Glu Ser 
    1100                 1105                 1110             


Asp Asp  Ala Asp Asp Thr Pro  Ile Leu Lys Pro Val  Ser Leu Leu 
    1115                 1120                 1125             


Arg Lys  Arg Asp Val Lys Asn  Ser Pro Leu Glu Pro  Asp Thr Ser 
    1130                 1135                 1140             


Thr Pro  Leu Lys Lys Lys Lys  Gly Trp Pro Lys Gly  Lys Ser Arg 
    1145                 1150                 1155             


Lys Pro  Ile His Trp Lys Lys  Arg Pro Gly Arg Lys  Pro Gly Phe 
    1160                 1165                 1170             


Lys Leu  Ser Arg Glu Ile Met  Pro Val Ser Thr Gln  Ala Cys Val 
    1175                 1180                 1185             


Ile Glu  Pro Ile Val Ser Ile  Pro Lys Ala Gly Arg  Lys Pro Lys 
    1190                 1195                 1200             


Ile Gln  Glu Ser Glu Glu Thr  Val Glu Pro Lys Glu  Asp Met Pro 
    1205                 1210                 1215             


Leu Pro  Glu Glu Arg Lys Glu  Glu Glu Glu Met Gln  Ala Glu Ala 
    1220                 1225                 1230             


Glu Glu  Ala Glu Glu Gly Glu  Glu Glu Asp Ala Ala  Ser Ser Glu 
    1235                 1240                 1245             


Val Pro  Ala Ala Ser Pro Ala  Asp Ser Ser Asn Ser  Pro Glu Thr 
    1250                 1255                 1260             


Glu Thr  Lys Glu Pro Glu Val  Glu Glu Glu Glu Glu  Lys Pro Arg 
    1265                 1270                 1275             


Val Ser  Glu Glu Gln Arg Gln  Ser Glu Glu Glu Gln  Gln Glu Leu 
    1280                 1285                 1290             


Glu Glu  Pro Glu Pro Glu Glu  Glu Glu Asp Ala Ala  Ala Glu Thr 
    1295                 1300                 1305             


Ala Gln  Asn Asp Asp His Asp  Ala Asp Asp Glu Asp  Asp Gly His 
    1310                 1315                 1320             


Leu Glu  Ser Thr Lys Lys Lys  Glu Leu Glu Glu Gln  Pro Thr Arg 
    1325                 1330                 1335             


Glu Asp  Val Lys Glu Glu Pro  Gly Val Gln Glu Ser  Phe Leu Asp 
    1340                 1345                 1350             


Ala Asn  Met Gln Lys Ser Arg  Glu Lys Ile Lys Asp  Lys Glu Glu 
    1355                 1360                 1365             


Thr Glu  Leu Asp Ser Glu Glu  Glu Gln Pro Ser His  Asp Thr Ser 
    1370                 1375                 1380             


Val Val  Ser Glu Gln Met Ala  Gly Ser Glu Asp Asp  His Glu Glu 
    1385                 1390                 1395             


Asp Ser  His Thr Lys Glu Glu  Leu Ile Glu Leu Lys  Glu Glu Glu 
    1400                 1405                 1410             


Glu Ile  Pro His Ser Glu Leu  Asp Leu Glu Thr Val  Gln Ala Val 
    1415                 1420                 1425             


Gln Ser  Leu Thr Gln Glu Glu  Ser Ser Glu His Glu  Gly Ala Tyr 
    1430                 1435                 1440             


Gln Asp  Cys Glu Glu Thr Leu  Ala Ala Cys Gln Thr  Leu Gln Ser 
    1445                 1450                 1455             


Tyr Thr  Gln Ala Asp Glu Asp  Pro Gln Met Ser Met  Val Glu Asp 
    1460                 1465                 1470             


Cys His  Ala Ser Glu His Asn  Ser Pro Ile Ser Ser  Val Gln Ser 
    1475                 1480                 1485             


His Pro  Ser Gln Ser Val Arg  Ser Val Ser Ser Pro  Asn Val Pro 
    1490                 1495                 1500             


Ala Leu  Glu Ser Gly Tyr Thr  Gln Ile Ser Pro Glu  Gln Gly Ser 
    1505                 1510                 1515             


Leu Ser  Ala Pro Ser Met Gln  Asn Met Glu Thr Ser  Pro Met Met 
    1520                 1525                 1530             


Asp Val  Pro Ser Val Ser Asp  His Ser Gln Gln Val  Val Asp Ser 
    1535                 1540                 1545             


Gly Phe  Ser Asp Leu Gly Ser  Ile Glu Ser Thr Thr  Glu Asn Tyr 
    1550                 1555                 1560             


Glu Asn  Pro Ser Ser Tyr Asp  Ser Thr Met Gly Gly  Ser Ile Cys 
    1565                 1570                 1575             


Gly Asn  Ser Ser Ser Gln Ser  Ser Cys Ser Tyr Gly  Gly Leu Ser 
    1580                 1585                 1590             


Ser Ser  Ser Ser Leu Thr Gln  Ser Ser Cys Val Val  Thr Gln Gln 
    1595                 1600                 1605             


Met Ala  Ser Met Gly Ser Ser  Cys Ser Met Met Gln  Gln Ser Ser 
    1610                 1615                 1620             


Val Gln  Pro Ala Ala Asn Cys  Ser Ile Lys Ser Pro  Gln Ser Cys 
    1625                 1630                 1635             


Val Val  Glu Arg Pro Pro Ser  Asn Gln Gln Gln Gln  Pro Pro Pro 
    1640                 1645                 1650             


Pro Pro  Pro Gln Gln Pro Gln  Pro Pro Pro Pro Gln  Pro Gln Pro 
    1655                 1660                 1665             


Ala Pro  Gln Pro Pro Pro Pro  Gln Gln Gln Pro Gln  Gln Gln Pro 
    1670                 1675                 1680             


Gln Pro  Gln Pro Gln Gln Pro  Pro Pro Pro Pro Pro  Pro Gln Gln 
    1685                 1690                 1695             


Gln Pro  Pro Leu Ser Gln Cys  Ser Met Asn Asn Ser  Phe Thr Pro 
    1700                 1705                 1710             


Ala Pro  Met Ile Met Glu Ile  Pro Glu Ser Gly Ser  Thr Gly Asn 
    1715                 1720                 1725             


Ile Ser  Ile Tyr Glu Arg Ile  Pro Gly Asp Phe Gly  Ala Gly Ser 
    1730                 1735                 1740             


Tyr Ser  Gln Pro Ser Ala Thr  Phe Ser Leu Ala Lys  Leu Gln Gln 
    1745                 1750                 1755             


Leu Thr  Asn Thr Ile Met Asp  Pro His Ala Met Pro  Tyr Ser His 
    1760                 1765                 1770             


Ser Pro  Ala Val Thr Ser Tyr  Ala Thr Ser Val Ser  Leu Ser Asn 
    1775                 1780                 1785             


Thr Gly  Leu Ala Gln Leu Ala  Pro Ser His Pro Leu  Ala Gly Thr 
    1790                 1795                 1800             


Pro Gln  Ala Gln Ala Thr Met  Thr Pro Pro Pro Asn  Leu Ala Ser 
    1805                 1810                 1815             


Thr Thr  Met Asn Leu Thr Ser  Pro Leu Leu Gln Cys  Asn Met Ser 
    1820                 1825                 1830             


Ala Thr  Asn Ile Gly Ile Pro  His Thr Gln Arg Leu  Gln Gly Gln 
    1835                 1840                 1845             


Met Pro  Val Lys Gly His Ile  Ser Ile Arg Ser Lys  Ser Ala Pro 
    1850                 1855                 1860             


Leu Pro  Ser Ala Ala Ala His  Gln Gln Gln Leu Tyr  Gly Arg Ser 
    1865                 1870                 1875             


Pro Ser  Ala Val Ala Met Gln  Ala Gly Pro Arg Ala  Leu Ala Val 
    1880                 1885                 1890             


Gln Arg  Gly Met Asn Met Gly  Val Asn Leu Met Pro  Thr Pro Ala 
    1895                 1900                 1905             


Tyr Asn  Val Asn Ser Met Asn  Met Asn Thr Leu Asn  Ala Met Asn 
    1910                 1915                 1920             


Ser Tyr  Arg Met Thr Gln Pro  Met Met Asn Ser Ser  Tyr His Ser 
    1925                 1930                 1935             


Asn Pro  Ala Tyr Met Asn Gln  Thr Ala Gln Tyr Pro  Met Gln Met 
    1940                 1945                 1950             


Gln Met  Gly Met Met Gly Ser  Gln Ala Tyr Thr Gln  Gln Pro Met 
    1955                 1960                 1965             


Gln Pro  Asn Pro His Gly Asn  Met Met Tyr Thr Gly  Pro Ser His 
    1970                 1975                 1980             


His Ser  Tyr Met Asn Ala Ala  Gly Val Pro Lys Gln  Ser Leu Asn 
    1985                 1990                 1995             


Gly Pro  Tyr Met Arg Arg 
    2000                 


<210>  5697
<211>  1890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAT6B__Homo_sapiens__NP_001243397

<400>  5697

Met Val Lys Leu Ala Asn Pro Leu Tyr Thr Glu Trp Ile Leu Glu Ala 
1               5                   10                  15      


Ile Gln Lys Ile Lys Lys Gln Lys Gln Arg Pro Ser Glu Glu Arg Ile 
            20                  25                  30          


Cys His Ala Val Ser Thr Ser His Gly Leu Asp Lys Lys Thr Val Ser 
        35                  40                  45              


Glu Gln Leu Glu Leu Ser Val Gln Asp Gly Ser Val Leu Lys Val Thr 
    50                  55                  60                  


Asn Lys Gly Leu Ala Ser Tyr Lys Asp Pro Asp Asn Pro Gly Arg Phe 
65                  70                  75                  80  


Ser Ser Val Lys Pro Gly Thr Phe Pro Lys Ser Ala Lys Gly Ser Arg 
                85                  90                  95      


Gly Ser Cys Asn Asp Leu Arg Asn Val Asp Trp Asn Lys Leu Leu Arg 
            100                 105                 110         


Arg Ala Ile Glu Gly Leu Glu Glu Pro Asn Gly Ser Ser Leu Lys Asn 
        115                 120                 125             


Ile Glu Lys Tyr Leu Arg Ser Gln Ser Asp Leu Thr Ser Thr Thr Asn 
    130                 135                 140                 


Asn Pro Ala Phe Gln Gln Arg Leu Arg Leu Gly Ala Lys Arg Ala Val 
145                 150                 155                 160 


Asn Asn Gly Arg Leu Leu Lys Asp Gly Pro Gln Tyr Arg Val Asn Tyr 
                165                 170                 175     


Gly Ser Leu Asp Gly Lys Gly Ala Pro Gln Tyr Pro Ser Ala Phe Pro 
            180                 185                 190         


Ser Ser Leu Pro Pro Val Ser Leu Leu Pro His Glu Lys Asp Gln Pro 
        195                 200                 205             


Arg Ala Asp Pro Ile Pro Ile Cys Ser Phe Cys Leu Gly Thr Lys Glu 
    210                 215                 220                 


Ser Asn Arg Glu Lys Lys Pro Glu Glu Leu Leu Ser Cys Ala Asp Cys 
225                 230                 235                 240 


Gly Ser Ser Gly His Pro Ser Cys Leu Lys Phe Cys Pro Glu Leu Thr 
                245                 250                 255     


Thr Asn Val Lys Ala Leu Arg Trp Gln Cys Ile Glu Cys Lys Thr Cys 
            260                 265                 270         


Ser Ala Cys Arg Val Gln Gly Arg Asn Ala Asp Asn Met Leu Phe Cys 
        275                 280                 285             


Asp Ser Cys Asp Arg Gly Phe His Met Glu Cys Cys Asp Pro Pro Leu 
    290                 295                 300                 


Ser Arg Met Pro Lys Gly Met Trp Ile Cys Gln Val Cys Arg Pro Lys 
305                 310                 315                 320 


Lys Lys Gly Arg Lys Leu Leu His Glu Lys Ala Ala Gln Ile Lys Arg 
                325                 330                 335     


Arg Tyr Ala Lys Pro Ile Gly Arg Pro Lys Asn Lys Leu Lys Gln Arg 
            340                 345                 350         


Leu Leu Ser Val Thr Ser Asp Glu Gly Ser Met Asn Ala Phe Thr Gly 
        355                 360                 365             


Arg Gly Ser Pro Gly Arg Gly Gln Lys Thr Lys Val Cys Thr Thr Pro 
    370                 375                 380                 


Ser Ser Gly His Ala Ala Ser Gly Lys Asp Ser Ser Ser Arg Leu Ala 
385                 390                 395                 400 


Val Thr Asp Pro Thr Arg Pro Gly Ala Thr Thr Lys Ile Thr Thr Thr 
                405                 410                 415     


Ser Thr Tyr Ile Ser Ala Ser Thr Leu Lys Val Asn Lys Lys Thr Lys 
            420                 425                 430         


Gly Leu Ile Asp Gly Leu Thr Lys Phe Phe Thr Pro Ser Pro Asp Gly 
        435                 440                 445             


Arg Arg Ser Arg Gly Glu Ile Ile Asp Phe Ser Lys His Tyr Arg Pro 
    450                 455                 460                 


Arg Lys Lys Val Ser Gln Lys Gln Ser Cys Thr Ser His Val Leu Ala 
465                 470                 475                 480 


Thr Asp Thr Glu Ile Lys Ile Asn Ile Lys Gln Glu Ser Ala Asp Val 
                485                 490                 495     


Asn Val Ile Gly Asn Lys Asp Val Val Thr Glu Glu Asp Leu Asp Val 
            500                 505                 510         


Phe Lys Gln Ala Gln Glu Leu Ser Trp Glu Lys Ile Glu Cys Glu Ser 
        515                 520                 525             


Gly Val Glu Asp Cys Gly Arg Tyr Pro Ser Val Ile Glu Phe Gly Lys 
    530                 535                 540                 


Tyr Glu Ile Gln Thr Trp Tyr Ser Ser Pro Tyr Pro Gln Glu Tyr Ala 
545                 550                 555                 560 


Arg Leu Pro Lys Leu Tyr Leu Cys Glu Phe Cys Leu Lys Tyr Met Lys 
                565                 570                 575     


Ser Lys Asn Ile Leu Leu Arg His Ser Lys Lys Cys Gly Trp Phe His 
            580                 585                 590         


Pro Pro Ala Asn Glu Ile Tyr Arg Arg Lys Asp Leu Ser Val Phe Glu 
        595                 600                 605             


Val Asp Gly Asn Met Ser Lys Ile Tyr Cys Gln Asn Leu Cys Leu Leu 
    610                 615                 620                 


Ala Lys Leu Phe Leu Asp His Lys Thr Leu Tyr Tyr Asp Val Glu Pro 
625                 630                 635                 640 


Phe Leu Phe Tyr Val Leu Thr Lys Asn Asp Glu Lys Gly Cys His Leu 
                645                 650                 655     


Val Gly Tyr Phe Ser Lys Glu Lys Leu Cys Gln Gln Lys Tyr Asn Val 
            660                 665                 670         


Ser Cys Ile Met Ile Met Pro Gln His Gln Arg Gln Gly Phe Gly Arg 
        675                 680                 685             


Phe Leu Ile Asp Phe Ser Tyr Leu Leu Ser Arg Arg Glu Gly Gln Ala 
    690                 695                 700                 


Gly Ser Pro Glu Lys Pro Leu Ser Asp Leu Gly Arg Leu Ser Tyr Leu 
705                 710                 715                 720 


Ala Tyr Trp Lys Ser Val Ile Leu Glu Tyr Leu Tyr His His His Glu 
                725                 730                 735     


Arg His Ile Ser Ile Lys Ala Ile Ser Arg Ala Thr Gly Met Cys Pro 
            740                 745                 750         


His Asp Ile Ala Thr Thr Leu Gln His Leu His Met Ile Asp Lys Arg 
        755                 760                 765             


Asp Gly Arg Phe Val Ile Ile Arg Arg Glu Lys Leu Ile Leu Ser His 
    770                 775                 780                 


Met Glu Lys Leu Lys Thr Cys Ser Arg Ala Asn Glu Leu Asp Pro Asp 
785                 790                 795                 800 


Ser Leu Arg Trp Thr Pro Ile Leu Ile Ser Asn Ala Ala Val Ser Glu 
                805                 810                 815     


Glu Glu Arg Glu Ala Glu Lys Glu Ala Glu Arg Leu Met Glu Gln Ala 
            820                 825                 830         


Ser Cys Trp Glu Lys Glu Glu Gln Glu Ile Leu Ser Thr Arg Ala Asn 
        835                 840                 845             


Ser Arg Gln Ser Pro Ala Lys Val Gln Ser Lys Asn Lys Tyr Leu His 
    850                 855                 860                 


Ser Pro Glu Ser Arg Pro Val Thr Gly Glu Arg Gly Gln Leu Leu Glu 
865                 870                 875                 880 


Leu Ser Lys Glu Ser Ser Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu 
                885                 890                 895     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu 
            900                 905                 910         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asn Ile Gln Ser Ser Pro Pro 
        915                 920                 925             


Arg Leu Thr Lys Pro Gln Ser Val Ala Ile Lys Arg Lys Arg Pro Phe 
    930                 935                 940                 


Val Leu Lys Lys Lys Arg Gly Arg Lys Arg Arg Arg Ile Asn Ser Ser 
945                 950                 955                 960 


Val Thr Thr Glu Thr Ile Ser Glu Thr Thr Glu Val Leu Asn Glu Pro 
                965                 970                 975     


Phe Asp Asn Ser Asp Glu Glu Arg Pro Met Pro Gln Leu Glu Pro Thr 
            980                 985                 990         


Cys Glu Ile Glu Val Glu Glu Asp  Gly Arg Lys Pro Val  Leu Arg Lys 
        995                 1000                 1005             


Ala Phe  Gln His Gln Pro Gly  Lys Lys Arg Gln Thr  Glu Glu Glu 
    1010                 1015                 1020             


Glu Gly  Lys Asp Asn His Cys  Phe Lys Asn Ala Asp  Pro Cys Arg 
    1025                 1030                 1035             


Asn Asn  Met Asn Asp Asp Ser  Ser Asn Leu Lys Glu  Gly Ser Lys 
    1040                 1045                 1050             


Asp Asn  Pro Glu Pro Leu Lys  Cys Lys Gln Val Trp  Pro Lys Gly 
    1055                 1060                 1065             


Thr Lys  Arg Gly Leu Ser Lys  Trp Arg Gln Asn Lys  Glu Arg Lys 
    1070                 1075                 1080             


Thr Gly  Phe Lys Leu Asn Leu  Tyr Thr Pro Pro Glu  Thr Pro Met 
    1085                 1090                 1095             


Glu Pro  Asp Glu Gln Val Thr  Val Glu Glu Gln Lys  Glu Thr Ser 
    1100                 1105                 1110             


Glu Gly  Lys Thr Ser Pro Ser  Pro Ile Arg Ile Glu  Glu Glu Val 
    1115                 1120                 1125             


Lys Glu  Thr Gly Glu Ala Leu  Leu Pro Gln Glu Glu  Asn Arg Arg 
    1130                 1135                 1140             


Glu Glu  Thr Cys Ala Pro Val  Ser Pro Asn Thr Ser  Pro Gly Glu 
    1145                 1150                 1155             


Lys Pro  Glu Asp Asp Leu Ile  Lys Pro Glu Glu Glu  Glu Glu Glu 
    1160                 1165                 1170             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Glu  Gly Glu Glu 
    1175                 1180                 1185             


Glu Glu  Gly Gly Gly Asn Val  Glu Lys Asp Pro Asp  Gly Ala Lys 
    1190                 1195                 1200             


Ser Gln  Glu Lys Glu Glu Pro  Glu Ile Ser Thr Glu  Lys Glu Asp 
    1205                 1210                 1215             


Ser Ala  Arg Leu Asp Asp His  Glu Glu Glu Glu Glu  Glu Asp Glu 
    1220                 1225                 1230             


Glu Pro  Ser His Asn Glu Asp  His Asp Ala Asp Asp  Glu Asp Asp 
    1235                 1240                 1245             


Ser His  Met Glu Ser Ala Glu  Val Glu Lys Glu Glu  Leu Pro Arg 
    1250                 1255                 1260             


Glu Ser  Phe Lys Glu Val Leu  Glu Asn Gln Glu Thr  Phe Leu Asp 
    1265                 1270                 1275             


Leu Asn  Val Gln Pro Gly His  Ser Asn Pro Glu Val  Leu Met Asp 
    1280                 1285                 1290             


Cys Gly  Val Asp Leu Thr Ala  Ser Cys Asn Ser Glu  Pro Lys Glu 
    1295                 1300                 1305             


Leu Ala  Gly Asp Pro Glu Ala  Val Pro Glu Ser Asp  Glu Glu Pro 
    1310                 1315                 1320             


Pro Pro  Gly Glu Gln Ala Gln  Lys Gln Asp Gln Lys  Asn Ser Lys 
    1325                 1330                 1335             


Glu Val  Asp Thr Glu Phe Lys  Glu Gly Asn Pro Ala  Thr Met Glu 
    1340                 1345                 1350             


Ile Asp  Ser Glu Thr Val Gln  Ala Val Gln Ser Leu  Thr Gln Glu 
    1355                 1360                 1365             


Ser Ser  Glu Gln Asp Asp Thr  Phe Gln Asp Cys Ala  Glu Thr Gln 
    1370                 1375                 1380             


Glu Ala  Cys Arg Ser Leu Gln  Asn Tyr Thr Arg Ala  Asp Gln Ser 
    1385                 1390                 1395             


Pro Gln  Ile Ala Thr Thr Leu  Asp Asp Cys Gln Gln  Ser Asp His 
    1400                 1405                 1410             


Ser Ser  Pro Val Ser Ser Val  His Ser His Pro Gly  Gln Ser Val 
    1415                 1420                 1425             


Arg Ser  Val Asn Ser Pro Ser  Val Pro Ala Leu Glu  Asn Ser Tyr 
    1430                 1435                 1440             


Ala Gln  Ile Ser Pro Asp Gln  Ser Ala Ile Ser Val  Pro Ser Leu 
    1445                 1450                 1455             


Gln Asn  Met Glu Thr Ser Pro  Met Met Asp Val Pro  Ser Val Ser 
    1460                 1465                 1470             


Asp His  Ser Gln Gln Val Val  Asp Ser Gly Phe Ser  Asp Leu Gly 
    1475                 1480                 1485             


Ser Ile  Glu Ser Thr Thr Glu  Asn Tyr Glu Asn Pro  Ser Ser Tyr 
    1490                 1495                 1500             


Asp Ser  Thr Met Gly Gly Ser  Ile Cys Gly Asn Gly  Ser Ser Gln 
    1505                 1510                 1515             


Asn Ser  Cys Ser Tyr Ser Asn  Leu Thr Ser Ser Ser  Leu Thr Gln 
    1520                 1525                 1530             


Ser Ser  Cys Ala Val Thr Gln  Gln Met Ser Asn Ile  Ser Gly Ser 
    1535                 1540                 1545             


Cys Ser  Met Leu Gln Gln Thr  Ser Ile Ser Ser Pro  Pro Thr Cys 
    1550                 1555                 1560             


Ser Val  Lys Ser Pro Gln Gly  Cys Val Val Glu Arg  Pro Pro Ser 
    1565                 1570                 1575             


Ser Ser  Gln Gln Leu Ala Gln  Cys Ser Met Ala Ala  Asn Phe Thr 
    1580                 1585                 1590             


Pro Pro  Met Gln Leu Ala Glu  Ile Pro Glu Thr Ser  Asn Ala Asn 
    1595                 1600                 1605             


Ile Gly  Leu Tyr Glu Arg Met  Gly Gln Ser Asp Phe  Gly Ala Gly 
    1610                 1615                 1620             


His Tyr  Pro Gln Pro Ser Ala  Thr Phe Ser Leu Ala  Lys Leu Gln 
    1625                 1630                 1635             


Gln Leu  Thr Asn Thr Leu Ile  Asp His Ser Leu Pro  Tyr Ser His 
    1640                 1645                 1650             


Ser Ala  Ala Val Thr Ser Tyr  Ala Asn Ser Ala Ser  Leu Ser Thr 
    1655                 1660                 1665             


Pro Leu  Ser Asn Thr Gly Leu  Val Gln Leu Ser Gln  Ser Pro His 
    1670                 1675                 1680             


Ser Val  Pro Gly Gly Pro Gln  Ala Gln Ala Thr Met  Thr Pro Pro 
    1685                 1690                 1695             


Pro Asn  Leu Thr Pro Pro Pro  Met Asn Leu Pro Pro  Pro Leu Leu 
    1700                 1705                 1710             


Gln Arg  Asn Met Ala Ala Ser  Asn Ile Gly Ile Ser  His Ser Gln 
    1715                 1720                 1725             


Arg Leu  Gln Thr Gln Ile Ala  Ser Lys Gly His Ile  Ser Met Arg 
    1730                 1735                 1740             


Thr Lys  Ser Ala Ser Leu Ser  Pro Ala Ala Ala Thr  His Gln Ser 
    1745                 1750                 1755             


Gln Ile  Tyr Gly Arg Ser Gln  Thr Val Ala Met Gln  Gly Pro Ala 
    1760                 1765                 1770             


Arg Thr  Leu Thr Met Gln Arg  Gly Met Asn Met Ser  Val Asn Leu 
    1775                 1780                 1785             


Met Pro  Ala Pro Ala Tyr Asn  Val Asn Ser Val Asn  Met Asn Met 
    1790                 1795                 1800             


Asn Thr  Leu Asn Ala Met Asn  Gly Tyr Ser Met Ser  Gln Pro Met 
    1805                 1810                 1815             


Met Asn  Ser Gly Tyr His Ser  Asn His Gly Tyr Met  Asn Gln Thr 
    1820                 1825                 1830             


Pro Gln  Tyr Pro Met Gln Met  Gln Met Gly Met Met  Gly Thr Gln 
    1835                 1840                 1845             


Pro Tyr  Ala Gln Gln Pro Met  Gln Thr Pro Pro His  Gly Asn Met 
    1850                 1855                 1860             


Met Tyr  Thr Ala Pro Gly His  His Gly Tyr Met Asn  Thr Gly Met 
    1865                 1870                 1875             


Ser Lys  Gln Ser Leu Asn Gly  Ser Tyr Met Arg Arg  
    1880                 1885                 1890 


<210>  5698
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAT7__Homo_sapiens__NP_001186084

<400>  5698

Met Pro Arg Arg Lys Arg Asn Ala Gly Ser Ser Ser Asp Gly Thr Glu 
1               5                   10                  15      


Asp Ser Asp Phe Ser Thr Asp Leu Glu His Thr Asp Ser Ser Glu Ser 
            20                  25                  30          


Asp Gly Thr Ser Arg Arg Ser Ala Arg Val Thr Arg Ser Ser Ala Arg 
        35                  40                  45              


Leu Ser Gln Ser Ser Gln Asp Ser Ser Pro Val Arg Asn Leu Gln Ser 
    50                  55                  60                  


Phe Gly Thr Glu Glu Pro Ala Tyr Ser Thr Arg Arg Val Thr Arg Ser 
65                  70                  75                  80  


Gln Gln Gln Pro Thr Pro Val Thr Pro Lys Lys Tyr Pro Leu Arg Gln 
                85                  90                  95      


Thr Arg Ser Ser Gly Ser Glu Thr Glu Gln Val Val Asp Phe Ser Asp 
            100                 105                 110         


Arg Glu Thr Lys Asn Thr Ala Asp His Asp Glu Ser Pro Pro Arg Thr 
        115                 120                 125             


Pro Thr Gly Asn Ala Pro Ser Ser Glu Ser Asp Ile Asp Ile Ser Ser 
    130                 135                 140                 


Pro Asn Val Ser His Asp Glu Ser Ile Ala Lys Asp Met Ser Leu Lys 
145                 150                 155                 160 


Asp Ser Gly Ser Asp Leu Ser His Arg Pro Lys Arg Arg Arg Phe His 
                165                 170                 175     


Glu Ser Tyr Asn Phe Asn Met Lys Cys Pro Thr Pro Gly Cys Asn Ser 
            180                 185                 190         


Leu Gly His Leu Thr Gly Lys His Glu Arg His Phe Ser Ile Ser Gly 
        195                 200                 205             


Cys Pro Leu Tyr His Asn Leu Ser Ala Asp Glu Cys Lys Ala Pro Thr 
    210                 215                 220                 


Glu Arg Gln Leu Arg Tyr Lys Glu Lys Val Ala Glu Leu Arg Lys Lys 
225                 230                 235                 240 


Arg Asn Ser Gly Leu Ser Lys Glu Gln Lys Glu Lys Tyr Met Glu His 
                245                 250                 255     


Arg Gln Thr Tyr Gly Asn Thr Arg Glu Pro Leu Leu Glu Asn Leu Thr 
            260                 265                 270         


Ser Glu Tyr Asp Leu Asp Leu Phe Arg Arg Ala Gln Ala Arg Ala Ser 
        275                 280                 285             


Glu Asp Leu Glu Lys Leu Arg Leu Gln Gly Gln Ile Thr Glu Gly Ser 
    290                 295                 300                 


Asn Met Ile Lys Thr Ile Ala Phe Gly Arg Tyr Glu Leu Asp Thr Trp 
305                 310                 315                 320 


Tyr His Ser Pro Tyr Pro Glu Glu Tyr Ala Arg Leu Gly Arg Leu Tyr 
                325                 330                 335     


Met Cys Glu Phe Cys Leu Lys Tyr Met Lys Ser Gln Thr Ile Leu Arg 
            340                 345                 350         


Arg His Met Ala Lys Cys Val Trp Lys His Pro Pro Gly Asp Glu Ile 
        355                 360                 365             


Tyr Arg Lys Gly Ser Ile Ser Val Phe Glu Val Asp Gly Lys Lys Asn 
    370                 375                 380                 


Lys Ile Tyr Cys Gln Asn Leu Cys Leu Leu Ala Lys Leu Phe Leu Asp 
385                 390                 395                 400 


His Lys Thr Leu Tyr Tyr Asp Val Glu Pro Phe Leu Phe Tyr Val Met 
                405                 410                 415     


Thr Glu Ala Asp Asn Thr Gly Cys His Leu Ile Gly Tyr Phe Ser Lys 
            420                 425                 430         


Glu Lys Asn Ser Phe Leu Asn Tyr Asn Val Ser Cys Ile Leu Thr Met 
        435                 440                 445             


Pro Gln Tyr Met Arg Gln Gly Tyr Gly Lys Met Leu Ile Asp Phe Ser 
    450                 455                 460                 


Tyr Leu Leu Ser Lys Val Glu Glu Lys Val Gly Ser Pro Glu Arg Pro 
465                 470                 475                 480 


Leu Ser Asp Leu Gly Leu Ile Ser Tyr Arg Ser Tyr Trp Lys Glu Val 
                485                 490                 495     


Leu Leu Arg Tyr Leu His Asn Phe Gln Gly Lys Glu Ile Ser Ile Lys 
            500                 505                 510         


Glu Ile Ser Gln Glu Thr Ala Val Asn Pro Val Asp Ile Val Ser Thr 
        515                 520                 525             


Leu Gln Ala Leu Gln Met Leu Lys Tyr Trp Lys Gly Lys His Leu Val 
    530                 535                 540                 


Leu Lys Arg Gln Asp Leu Ile Asp Glu Trp Ile Ala Lys Glu Ala Lys 
545                 550                 555                 560 


Arg Ser Asn Ser Asn Lys Thr Met Asp Pro Ser Cys Leu Lys Trp Thr 
                565                 570                 575     


Pro Pro Lys Gly Thr 
            580     


<210>  5699
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAT8__Homo_sapiens__NP_115564

<400>  5699

Met Ala Ala Gln Gly Ala Ala Ala Ala Val Ala Ala Gly Thr Ser Gly 
1               5                   10                  15      


Val Ala Gly Glu Gly Glu Pro Gly Pro Gly Glu Asn Ala Ala Ala Glu 
            20                  25                  30          


Gly Thr Ala Pro Ser Pro Gly Arg Val Ser Pro Pro Thr Pro Ala Arg 
        35                  40                  45              


Gly Glu Pro Glu Val Thr Val Glu Ile Gly Glu Thr Tyr Leu Cys Arg 
    50                  55                  60                  


Arg Pro Asp Ser Thr Trp His Ser Ala Glu Val Ile Gln Ser Arg Val 
65                  70                  75                  80  


Asn Asp Gln Glu Gly Arg Glu Glu Phe Tyr Val His Tyr Val Gly Phe 
                85                  90                  95      


Asn Arg Arg Leu Asp Glu Trp Val Asp Lys Asn Arg Leu Ala Leu Thr 
            100                 105                 110         


Lys Thr Val Lys Asp Ala Val Gln Lys Asn Ser Glu Lys Tyr Leu Ser 
        115                 120                 125             


Glu Leu Ala Glu Gln Pro Glu Arg Lys Ile Thr Arg Asn Gln Lys Arg 
    130                 135                 140                 


Lys His Asp Glu Ile Asn His Val Gln Lys Thr Tyr Ala Glu Met Asp 
145                 150                 155                 160 


Pro Thr Thr Ala Ala Leu Glu Lys Glu His Glu Ala Ile Thr Lys Val 
                165                 170                 175     


Lys Tyr Val Asp Lys Ile His Ile Gly Asn Tyr Glu Ile Asp Ala Trp 
            180                 185                 190         


Tyr Phe Ser Pro Phe Pro Glu Asp Tyr Gly Lys Gln Pro Lys Leu Trp 
        195                 200                 205             


Leu Cys Glu Tyr Cys Leu Lys Tyr Met Lys Tyr Glu Lys Ser Tyr Arg 
    210                 215                 220                 


Phe His Leu Gly Gln Cys Gln Trp Arg Gln Pro Pro Gly Lys Glu Ile 
225                 230                 235                 240 


Tyr Arg Lys Ser Asn Ile Ser Val Tyr Glu Val Asp Gly Lys Asp His 
                245                 250                 255     


Lys Ile Tyr Cys Gln Asn Leu Cys Leu Leu Ala Lys Leu Phe Leu Asp 
            260                 265                 270         


His Lys Thr Leu Tyr Phe Asp Val Glu Pro Phe Val Phe Tyr Ile Leu 
        275                 280                 285             


Thr Glu Val Asp Arg Gln Gly Ala His Ile Val Gly Tyr Phe Ser Lys 
    290                 295                 300                 


Glu Lys Glu Ser Pro Asp Gly Asn Asn Val Ala Cys Ile Leu Thr Leu 
305                 310                 315                 320 


Pro Pro Tyr Gln Arg Arg Gly Tyr Gly Lys Phe Leu Ile Ala Phe Ser 
                325                 330                 335     


Tyr Glu Leu Ser Lys Leu Glu Ser Thr Val Gly Ser Pro Glu Lys Pro 
            340                 345                 350         


Leu Ser Asp Leu Gly Lys Leu Ser Tyr Arg Ser Tyr Trp Ser Trp Val 
        355                 360                 365             


Leu Leu Glu Ile Leu Arg Asp Phe Arg Gly Thr Leu Ser Ile Lys Asp 
    370                 375                 380                 


Leu Ser Gln Met Thr Ser Ile Thr Gln Asn Asp Ile Ile Ser Thr Leu 
385                 390                 395                 400 


Gln Ser Leu Asn Met Val Lys Tyr Trp Lys Gly Gln His Val Ile Cys 
                405                 410                 415     


Val Thr Pro Lys Leu Val Glu Glu His Leu Lys Ser Ala Gln Tyr Lys 
            420                 425                 430         


Lys Pro Pro Ile Thr Val Asp Ser Val Cys Leu Lys Trp Ala Pro Pro 
        435                 440                 445             


Lys His Lys Gln Val Lys Leu Ser Lys Lys 
    450                 455             


<210>  5700
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KATNA1__Homo_sapiens__NP_001191005

<400>  5700

Met Ser Leu Leu Met Ile Ser Glu Asn Val Lys Leu Ala Arg Glu Tyr 
1               5                   10                  15      


Ala Leu Leu Gly Asn Tyr Asp Ser Ala Met Val Tyr Tyr Gln Gly Val 
            20                  25                  30          


Leu Asp Gln Met Asn Lys Tyr Leu Tyr Ser Val Lys Asp Thr Tyr Leu 
        35                  40                  45              


Gln Gln Lys Trp Gln Gln Val Trp Gln Glu Ile Asn Val Glu Ala Lys 
    50                  55                  60                  


His Val Lys Asp Ile Met Lys Thr Leu Glu Ser Phe Lys Leu Asp Ser 
65                  70                  75                  80  


Thr Pro Leu Lys Ala Ala Gln His Asp Leu Pro Ala Ser Glu Gly Glu 
                85                  90                  95      


Val Trp Ser Met Pro Val Pro Val Glu Arg Arg Pro Ser Pro Gly Pro 
            100                 105                 110         


Arg Lys Arg Gln Ser Ser Gln Tyr Ser Asp Pro Lys Ser His Gly Asn 
        115                 120                 125             


Arg Pro Ser Thr Thr Val Arg Val His Arg Ser Ser Ala Gln Asn Val 
    130                 135                 140                 


His Asn Asp Arg Gly Lys Ala Val Arg Cys Arg Glu Lys Lys Glu Gln 
145                 150                 155                 160 


Asn Lys Gly Arg Glu Glu Lys Gly Val Leu Met Val Gly Pro Pro Gly 
                165                 170                 175     


Thr Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Thr Glu Cys Lys Thr 
            180                 185                 190         


Thr Phe Phe Asn Val Ser Ser Ser Thr Leu Thr Ser Lys Tyr Arg Gly 
        195                 200                 205             


Glu Ser Glu Lys Leu Val Arg Leu Leu Phe Glu Met Ala Arg Phe Tyr 
    210                 215                 220                 


Ser Pro Ala Thr Ile Phe Ile Asp Glu Ile Asp Ser Ile Cys Ser Arg 
225                 230                 235                 240 


Arg Gly Thr Ser Glu Glu His Glu Ala Ser Arg Arg Val Lys Ala Glu 
                245                 250                 255     


Leu Leu Val Gln Met Asp Gly Val Gly Gly Thr Ser Glu Asn Asp Asp 
            260                 265                 270         


Pro Ser Lys Met Val Met Val Leu Ala Ala Thr Asn Phe Pro Trp Asp 
        275                 280                 285             


Ile Asp Glu Ala Leu Arg Arg Arg Leu Glu Lys Arg Ile Tyr Ile Pro 
    290                 295                 300                 


Leu Pro Ser Gly Met Arg Pro 
305                 310     


<210>  5701
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KATNAL2__Homo_sapiens__XP_005258414

<400>  5701

Met Lys Lys Ile Glu Gln Arg Lys Thr Arg Pro Cys Phe Ser Thr Ser 
1               5                   10                  15      


Asn Glu Asn Arg Val Leu Ala Gln Cys Leu Met Glu Leu Ser Tyr Gln 
            20                  25                  30          


Thr Leu Lys Phe Thr His Gln Ala Arg Glu Ala Cys Glu Met Arg Thr 
        35                  40                  45              


Glu Ala Arg Arg Lys Asn Leu Leu Ile Leu Ile Ser His Tyr Leu Thr 
    50                  55                  60                  


Gln Glu Gly Tyr Ile Asp Thr Ala Asn Ala Leu Glu Gln Glu Thr Lys 
65                  70                  75                  80  


Leu Gly Leu Arg Arg Phe Glu Val Cys Asp Asn Ile Asp Leu Glu Thr 
                85                  90                  95      


Ile Leu Met Glu Tyr Glu Ser Tyr Tyr Phe Val Lys Phe Gln Lys Tyr 
            100                 105                 110         


Pro Lys Ile Val Lys Lys Ser Ser Asp Thr Ala Glu Asn Asn Leu Pro 
        115                 120                 125             


Gln Arg Ser Arg Gly Lys Thr Arg Arg Met Met Asn Asp Ser Cys Gln 
    130                 135                 140                 


Asn Leu Pro Lys Ile Asn Gln Gln Arg Pro Arg Ser Lys Thr Thr Ala 
145                 150                 155                 160 


Gly Lys Thr Gly Asp Thr Lys Ser Leu Asn Lys Glu His Pro Asn Gln 
                165                 170                 175     


Glu Val Val Asp Asn Thr Arg Leu Glu Ser Ala Asn Phe Gly Leu His 
            180                 185                 190         


Ile Ser Arg Ile Arg Lys Asp Ser Gly Glu Glu Asn Ala His Pro Arg 
        195                 200                 205             


Arg Gly Gln Ile Ile Asp Phe Gln Gly Leu Leu Thr Asp Ala Ile Lys 
    210                 215                 220                 


Gly Ala Thr Ser Glu Leu Ala Leu Asn Thr Phe Asp His Asn Pro Asp 
225                 230                 235                 240 


Pro Ser Glu Arg Leu Leu Lys Pro Leu Ser Ala Phe Ile Gly Met Asn 
                245                 250                 255     


Ser Glu Met Arg Glu Leu Ala Ala Val Val Ser Arg Asp Ile Tyr Leu 
            260                 265                 270         


His Asn Pro Asn Ile Lys Trp Asn Asp Ile Ile Gly Leu Asp Ala Ala 
        275                 280                 285             


Lys Gln Leu Val Lys Glu Ala Val Val Tyr Pro Ile Arg Tyr Pro Gln 
    290                 295                 300                 


Leu Phe Thr Gly Ile Leu Ser Pro Trp Lys Gly Leu Leu Leu Tyr Gly 
305                 310                 315                 320 


Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Thr Glu 
                325                 330                 335     


Cys Lys Thr Thr Phe Phe Asn Ile Ser Ala Ser Thr Ile Val Ser Lys 
            340                 345                 350         


Trp Arg Gly Asp Ser Glu Lys Leu Val Arg Val Leu Phe Glu Leu Ala 
        355                 360                 365             


Arg Tyr His Ala Pro Ser Thr Ile Phe Leu Asp Glu Leu Glu Ser Val 
    370                 375                 380                 


Met Ser Gln Arg Gly Thr Ala Ser Gly Gly Glu His Glu Gly Ser Leu 
385                 390                 395                 400 


Arg Met Lys Thr Glu Leu Leu Val Gln Met Asp Gly Leu Ala Arg Ser 
                405                 410                 415     


Glu Asp Leu Val Phe Val Leu Ala Ala Ser Asn Leu Pro Trp Glu Leu 
            420                 425                 430         


Asp Cys Ala Met Leu Arg Arg Leu Glu Lys Arg Ile Leu Val Asp Leu 
        435                 440                 445             


Pro Ser Arg Glu Ala Arg Gln Ala Met Ile Tyr His Trp Leu Pro Pro 
    450                 455                 460                 


Val Ser Lys Ser Arg Ala Leu Glu Leu His Thr Glu Leu Glu Tyr Ser 
465                 470                 475                 480 


Val Leu Ser Gln Glu Thr Glu Gly Tyr Ser Gly Ser Asp Ile Lys Leu 
                485                 490                 495     


Val Cys Arg Glu Ala Ala Met Arg Pro Val Arg Lys Ile Phe Asp Ala 
            500                 505                 510         


Leu Glu Asn His Gln Ser Glu Ser Ser Asp Leu Pro Arg Ile Gln Leu 
        515                 520                 525             


Asp Ile Val Thr Thr Ala Asp Phe Leu Asp Val Leu Thr His Thr Lys 
    530                 535                 540                 


Pro Ser Ala Lys Asn Leu Ala Gln Arg Tyr Ser Asp Trp Gln Arg Glu 
545                 550                 555                 560 


Phe Glu Ser Val 
                


<210>  5702
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KATNB1__Homo_sapiens__NP_005877

<400>  5702

Met Ala Thr Pro Val Val Thr Lys Thr Ala Trp Lys Leu Gln Glu Ile 
1               5                   10                  15      


Val Ala His Ala Ser Asn Val Ser Ser Leu Val Leu Gly Lys Ala Ser 
            20                  25                  30          


Gly Arg Leu Leu Ala Thr Gly Gly Asp Asp Cys Arg Val Asn Leu Trp 
        35                  40                  45              


Ser Ile Asn Lys Pro Asn Cys Ile Met Ser Leu Thr Gly His Thr Ser 
    50                  55                  60                  


Pro Val Glu Ser Val Arg Leu Asn Thr Pro Glu Glu Leu Ile Val Ala 
65                  70                  75                  80  


Gly Ser Gln Ser Gly Ser Ile Arg Val Trp Asp Leu Glu Ala Ala Lys 
                85                  90                  95      


Ile Leu Arg Thr Leu Met Gly His Lys Ala Asn Ile Cys Ser Leu Asp 
            100                 105                 110         


Phe His Pro Tyr Gly Glu Phe Val Ala Ser Gly Ser Gln Asp Thr Asn 
        115                 120                 125             


Ile Lys Leu Trp Asp Ile Arg Arg Lys Gly Cys Val Phe Arg Tyr Arg 
    130                 135                 140                 


Gly His Ser Gln Ala Val Arg Cys Leu Arg Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Trp Leu Ala Ser Ala Ala Asp Asp His Thr Val Lys Leu Trp Asp Leu 
                165                 170                 175     


Thr Ala Gly Lys Met Met Ser Glu Phe Pro Gly His Thr Gly Pro Val 
            180                 185                 190         


Asn Val Val Glu Phe His Pro Asn Glu Tyr Leu Leu Ala Ser Gly Ser 
        195                 200                 205             


Ser Asp Arg Thr Ile Arg Phe Trp Asp Leu Glu Lys Phe Gln Val Val 
    210                 215                 220                 


Ser Cys Ile Glu Gly Glu Pro Gly Pro Val Arg Ser Val Leu Phe Asn 
225                 230                 235                 240 


Pro Asp Gly Cys Cys Leu Tyr Ser Gly Cys Gln Asp Ser Leu Arg Val 
                245                 250                 255     


Tyr Gly Trp Glu Pro Glu Arg Cys Phe Asp Val Val Leu Val Asn Trp 
            260                 265                 270         


Gly Lys Val Ala Asp Leu Ala Ile Cys Asn Asp Gln Leu Ile Gly Val 
        275                 280                 285             


Ala Phe Ser Gln Ser Asn Val Ser Ser Tyr Val Val Asp Leu Thr Arg 
    290                 295                 300                 


Val Thr Arg Thr Gly Thr Val Ala Arg Asp Pro Val Gln Asp His Arg 
305                 310                 315                 320 


Pro Leu Ala Gln Pro Leu Pro Asn Pro Ser Ala Pro Leu Arg Arg Ile 
                325                 330                 335     


Tyr Glu Arg Pro Ser Thr Thr Cys Ser Lys Pro Gln Arg Val Lys Gln 
            340                 345                 350         


Asn Ser Glu Ser Glu Arg Arg Ser Pro Ser Ser Glu Asp Asp Arg Asp 
        355                 360                 365             


Glu Arg Glu Ser Arg Ala Glu Ile Gln Asn Ala Glu Asp Tyr Asn Glu 
    370                 375                 380                 


Ile Phe Gln Pro Lys Asn Ser Ile Ser Arg Thr Pro Pro Arg Arg Ser 
385                 390                 395                 400 


Glu Pro Phe Pro Ala Pro Pro Glu Asp Asp Ala Ala Thr Ala Lys Glu 
                405                 410                 415     


Ala Ala Lys Pro Ser Pro Ala Met Asp Val Gln Phe Pro Val Pro Asn 
            420                 425                 430         


Leu Glu Val Leu Pro Arg Pro Pro Val Val Ala Ser Thr Pro Ala Pro 
        435                 440                 445             


Lys Ala Glu Pro Ala Ile Ile Pro Ala Thr Arg Asn Glu Pro Ile Gly 
    450                 455                 460                 


Leu Lys Ala Ser Asp Phe Leu Pro Ala Val Lys Ile Pro Gln Gln Ala 
465                 470                 475                 480 


Glu Leu Val Asp Glu Asp Ala Met Ser Gln Ile Arg Lys Gly His Asp 
                485                 490                 495     


Thr Met Cys Val Val Leu Thr Ser Arg His Lys Asn Leu Asp Thr Val 
            500                 505                 510         


Arg Ala Val Trp Thr Met Gly Asp Ile Lys Thr Ser Val Asp Ser Ala 
        515                 520                 525             


Val Ala Ile Asn Asp Leu Ser Val Val Val Asp Leu Leu Asn Ile Val 
    530                 535                 540                 


Asn Gln Lys Ala Ser Leu Trp Lys Leu Asp Leu Cys Thr Thr Val Leu 
545                 550                 555                 560 


Pro Gln Ile Glu Lys Leu Leu Gln Ser Lys Tyr Glu Ser Tyr Val Gln 
                565                 570                 575     


Thr Gly Cys Thr Ser Leu Lys Leu Ile Leu Gln Arg Phe Leu Pro Leu 
            580                 585                 590         


Ile Thr Asp Met Leu Ala Ala Pro Pro Ser Val Gly Val Asp Ile Ser 
        595                 600                 605             


Arg Glu Glu Arg Leu His Lys Cys Arg Leu Cys Tyr Lys Gln Leu Lys 
    610                 615                 620                 


Ser Ile Ser Gly Leu Val Lys Ser Lys Ser Gly Leu Ser Gly Arg His 
625                 630                 635                 640 


Gly Ser Thr Phe Arg Glu Leu His Leu Leu Met Ala Ser Leu Asp 
                645                 650                 655 


<210>  5703
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAZALD1__Homo_sapiens__XP_005270251

<400>  5703

Met Leu Pro Pro Pro Arg Pro Ala Ala Ala Leu Ala Leu Pro Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Leu Thr Pro Pro Pro Thr Gly Ala Arg Pro 
            20                  25                  30          


Ser Pro Gly Pro Asp Tyr Leu Arg Arg Gly Trp Met Arg Leu Leu Ala 
        35                  40                  45              


Glu Gly Glu Gly Cys Ala Pro Cys Arg Pro Glu Glu Cys Ala Ala Pro 
    50                  55                  60                  


Arg Gly Cys Leu Ala Gly Arg Val Arg Asp Ala Cys Gly Cys Cys Trp 
65                  70                  75                  80  


Glu Cys Ala Asn Leu Glu Gly Gln Leu Cys Asp Leu Asp Pro Ser Ala 
                85                  90                  95      


His Phe Tyr Gly His Cys Gly Glu Gln Leu Glu Cys Arg Leu Asp Thr 
            100                 105                 110         


Gly Gly Asp Leu Ser Arg Gly Glu Val Pro Glu Pro Leu Cys Ala Cys 
        115                 120                 125             


Arg Ser Gln Ser Pro Leu Cys Gly Ser Asp Gly His Thr Tyr Ser Gln 
    130                 135                 140                 


Ile Cys Arg Leu Gln Glu Ala Ala Arg Ala Arg Pro Asp Ala Asn Leu 
145                 150                 155                 160 


Thr Val Ala His Pro Gly Pro Cys Glu Ser Gly Pro Gln Ile Val Ser 
                165                 170                 175     


His Pro Tyr Asp Thr Trp Asn Val Thr Gly Gln Asp Val Ile Phe Gly 
            180                 185                 190         


Cys Glu Val Phe Ala Tyr Pro Met Ala Ser Ile Glu Trp Arg Lys Asp 
        195                 200                 205             


Gly Leu Asp Ile Gln Leu Pro Gly Asp Asp Pro His Ile Ser Val Gln 
    210                 215                 220                 


Gly Trp Thr Pro Glu Val 
225                 230 


<210>  5704
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KAZN__Homo_sapiens__XP_011539377

<400>  5704

Met Arg Ala Ala Asp Ser Gly Ser Trp Glu Arg Val Arg Gln Leu Ala 
1               5                   10                  15      


Ala Gln Gly Glu Pro Ala Pro Ser Cys Gly Ala Gly Ala Gly Pro Ala 
            20                  25                  30          


Arg Pro Pro Gly Pro Ala Ala Cys Glu Gln Cys Val Asp Ala Ala Gly 
        35                  40                  45              


Pro Gly Asp Arg Pro Arg Ala Gly Val Pro Arg Val Arg Ala Asp Gly 
    50                  55                  60                  


Asp Cys Ser Gln Pro Val Leu Leu Arg Glu Glu Val Ser Arg Leu Gln 
65                  70                  75                  80  


Glu Glu Val His Leu Leu Arg Gln Met Lys Glu Met Leu Ala Lys Asp 
                85                  90                  95      


Leu Glu Glu Ser Gln Gly Gly Lys Ser Ser Glu Val Leu Ser Ala Thr 
            100                 105                 110         


Glu Leu Arg Val Gln Leu Ala Gln Lys Glu Gln Glu Leu Ala Arg Ala 
        115                 120                 125             


Lys Glu Ala Leu Gln Ala Met Lys Ala Asp Arg Lys Arg Leu Lys Gly 
    130                 135                 140                 


Glu Lys Thr Asp Leu Val Ser Gln Met Gln Gln Leu Tyr Ala Thr Leu 
145                 150                 155                 160 


Glu Ser Arg Glu Glu Gln Leu Arg Asp Phe Ile Arg Asn Tyr Glu Gln 
                165                 170                 175     


His Arg Lys Glu Ser Glu Asp Ala Val Lys Ala Leu Ala Lys Glu Lys 
            180                 185                 190         


Asp Leu Leu Glu Arg Glu Lys Trp Glu Leu Arg Arg Gln Ala Lys Glu 
        195                 200                 205             


Ala Thr Asp His Ala Thr Ala Leu Arg Ser Gln Leu Asp Leu Lys Asp 
    210                 215                 220                 


Asn Arg Met Lys Glu Leu Glu Ala Glu Leu Ala Met Ala Lys Gln Ser 
225                 230                 235                 240 


Leu Ala Thr Leu Thr Lys Asp Val Pro Lys Arg His Ser Leu Ala Met 
                245                 250                 255     


Pro Gly Glu Thr Val Leu Asn Gly Asn Gln Glu Trp Val Val Gln Ala 
            260                 265                 270         


Asp Leu Pro Leu Thr Ala Ala Ile Arg Gln Ser Gln Gln Thr Leu Tyr 
        275                 280                 285             


His Ser His Pro Pro His Pro Ala Asp Arg Gln Ala Val Arg Val Ser 
    290                 295                 300                 


Pro Cys His Ser Arg Gln Pro Ser Val Ile Ser Asp Ala Ser Ala Ala 
305                 310                 315                 320 


Glu Gly Asp Arg Ser Ser Thr Pro Ser Asp Ile Asn Ser Pro Arg His 
                325                 330                 335     


Arg Thr His Ser Leu Cys Asn Gly Asp Ser Pro Gly Pro Val Gln Lys 
            340                 345                 350         


Asn Leu His Asn Pro Ile Val Gln Ser Leu Glu Asp Leu Glu Asp Gln 
        355                 360                 365             


Lys Arg Lys Lys Lys Lys Glu Lys Met Gly Phe Gly Ser Ile Ser Arg 
    370                 375                 380                 


Val Phe Ala Arg Gly Lys Gln Arg Lys Ser Leu Asp Pro Gly Leu Phe 
385                 390                 395                 400 


Asp Asp Ser Asp Ser Gln Cys Ser Pro Thr Arg Gln Ser Leu Ser Leu 
                405                 410                 415     


Ser Glu Gly Glu Glu Gln Met Asp Arg Leu Gln Gln Val Glu Leu Val 
            420                 425                 430         


Arg Thr Thr Pro Met Ser His Trp Lys Ala Gly Thr Val Gln Ala Trp 
        435                 440                 445             


Leu Glu Val Val Met Ala Met Pro Met Tyr Val Lys Ala Cys Thr Glu 
    450                 455                 460                 


Asn Val Lys Ser Gly Lys Val Leu Leu Ser Leu Ser Asp Glu Asp Leu 
465                 470                 475                 480 


Gln Leu Gly Leu Gly Val Cys Ser Ser Leu His Arg Arg Lys Leu Arg 
                485                 490                 495     


Leu Ala Ile Glu Asp Tyr Arg Asp Ala Glu Ala Gly Arg Ser Leu Ser 
            500                 505                 510         


Lys Ala Ala Glu Leu Asp His His Trp Val Ala Lys Ala Trp Leu Asn 
        515                 520                 525             


Asp Ile Gly Leu Ser Gln Tyr Ser Gln Ala Phe Gln Asn His Leu Val 
    530                 535                 540                 


Asp Gly Arg Met Leu Asn Ser Leu Met Lys Arg Asp Leu Glu Lys His 
545                 550                 555                 560 


Leu Asn Val Ser Lys Lys Phe His Gln Val Ser Ile Leu Leu Gly Ile 
                565                 570                 575     


Glu Leu Leu Tyr Gln Val Asn Phe Ser Arg Glu Ala Leu Gln Glu Arg 
            580                 585                 590         


Arg Ala Arg Cys Glu Thr Gln Asn Ile Asp Pro Val Val Trp Thr Asn 
        595                 600                 605             


Gln Arg Val Leu Lys Trp Val Arg Asp Ile Asp Leu Lys Glu Tyr Ala 
    610                 615                 620                 


Asp Asn Leu Thr Asn Ser Gly Val His Gly Ala Val Leu Val Leu Glu 
625                 630                 635                 640 


Pro Thr Phe Asn Ala Glu Ala Met Ala Thr Ala Leu Gly Ile Pro Ser 
                645                 650                 655     


Gly Lys His Ile Leu Arg Arg His Leu Ala Glu Glu Met Ser Ala Val 
            660                 665                 670         


Phe His Pro Ala Asn Ser Thr Gly Ile Arg Glu Ala Glu Arg Phe Gly 
        675                 680                 685             


Thr Pro Pro Gly Arg Ala Ser Ser Val Thr Arg Ala Gly Lys Glu Glu 
    690                 695                 700                 


Asn Ser Ser Gly Leu Lys Tyr Lys Ala Gly Arg Val Ser Leu Ser Met 
705                 710                 715                 720 


Asp Leu Pro Val Ser Pro Ala Asp Pro Gly Lys Val Phe Phe Ser Pro 
                725                 730                 735     


Pro Gly Ser Ser Val Ala Pro Val Leu Ala Cys Glu Gly Gly Val Pro 
            740                 745                 750         


Gly Arg Val Thr Gly Ala Ser Arg Thr Asp Ala Leu Asp Val Pro Ser 
        755                 760                 765             


Arg Asn Leu His Asp Ala Leu Gly Thr Val His Lys Ala Pro Ala Gly 
    770                 775                 780                 


Leu Arg Val Ala Pro Gly Ser Gln Ser Ala Gly Leu Thr Cys Leu His 
785                 790                 795                 800 


Glu Asn His Leu Gly Leu Leu Leu Asn Leu Gln Ile Leu Gly Pro Thr 
                805                 810                 815     


Leu Val Ser Trp Lys Arg Ser Ser Leu Gly Arg Gly Gly Ser Cys Ile 
            820                 825                 830         


Gln Leu Gly Cys Pro Glu Gly Ser Gly Ala Ala Pro Asn Ser Glu Pro 
        835                 840                 845             


Gln Ser Leu Ile Ser Ile Cys Asp Phe Ser Asp Leu Thr Asn Ser Lys 
    850                 855                 860                 


Asp Glu Pro Ser Gly Asp Ser Asn Gln Thr Val 
865                 870                 875 


<210>  5705
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KBTBD11__Homo_sapiens__NP_055682

<400>  5705

Met Glu His Ala Val Ala Pro Cys Val Leu Tyr Pro Gly Thr Glu Pro 
1               5                   10                  15      


Gly Ala Ala Gly Glu Ser Glu Ser Glu Gly Ala Ala Ser Pro Ala Gln 
            20                  25                  30          


Thr Pro Cys Ser Leu Gly Ala Ser Leu Cys Phe Ser Ser Gly Glu Glu 
        35                  40                  45              


Ser Pro Pro Gln Ser Leu Ala Ser Ala Ala Glu Gly Ala Ala Thr Ser 
    50                  55                  60                  


Pro Pro Ser Ser Gly Gly Pro Arg Val Val Glu Arg Gln Trp Glu Ala 
65                  70                  75                  80  


Gly Ser Ala Gly Ala Ala Ser Pro Glu Glu Leu Ala Ser Pro Glu Glu 
                85                  90                  95      


Arg Ala Cys Pro Glu Glu Pro Ala Ala Pro Ser Pro Glu Pro Arg Val 
            100                 105                 110         


Trp Leu Glu Asp Pro Ala Ser Pro Glu Glu Pro Gly Glu Pro Ala Pro 
        115                 120                 125             


Val Pro Pro Gly Phe Gly Ala Val Tyr Gly Glu Pro Asp Leu Val Leu 
    130                 135                 140                 


Glu Val Ser Gly Arg Arg Leu Arg Ala His Lys Ala Val Leu Ala Ala 
145                 150                 155                 160 


Arg Ser Asp Tyr Phe Arg Ala Arg Ala Ser Arg Asp Val Leu Arg Val 
                165                 170                 175     


Gln Gly Val Ser Leu Thr Ala Leu Arg Leu Leu Leu Ala Asp Ala Tyr 
            180                 185                 190         


Ser Gly Arg Met Ala Gly Val Arg Pro Asp Asn Val Ala Glu Val Val 
        195                 200                 205             


Ala Gly Ala Arg Arg Leu Gln Leu Pro Gly Ala Ala Gln Arg Ala Thr 
    210                 215                 220                 


Asp Ala Val Gly Pro Gln Leu Ser Leu Ala Asn Cys Tyr Glu Val Leu 
225                 230                 235                 240 


Ser Ala Ala Lys Arg Gln Arg Leu Asn Glu Leu Arg Asp Ala Ala Tyr 
                245                 250                 255     


Cys Phe Met Ser Asp His Tyr Leu Glu Val Leu Arg Glu Pro Ala Val 
            260                 265                 270         


Phe Gly Arg Leu Ser Gly Ala Glu Arg Asp Leu Leu Leu Arg Arg Arg 
        275                 280                 285             


Leu Arg Ala Gly Arg Ala His Leu Leu Ala Ala Ala Leu Gly Pro Ala 
    290                 295                 300                 


Gly Glu Arg Ala Gly Ser Arg Pro Gln Ser Pro Ser Gly Asp Ala Asp 
305                 310                 315                 320 


Ala Arg Gly Asp Ala Ala Val Tyr Cys Phe His Ala Ala Ala Gly Glu 
                325                 330                 335     


Trp Arg Glu Leu Thr Arg Leu Pro Glu Gly Ala Pro Ala Arg Gly Cys 
            340                 345                 350         


Gly Leu Cys Val Leu Tyr Asn Tyr Leu Phe Val Ala Gly Gly Val Ala 
        355                 360                 365             


Pro Ala Gly Pro Asp Gly Arg Ala Arg Pro Ser Asp Gln Val Phe Cys 
    370                 375                 380                 


Tyr Asn Pro Ala Thr Asp Ser Trp Ser Ala Val Arg Pro Leu Arg Gln 
385                 390                 395                 400 


Ala Arg Ser Gln Leu Arg Leu Leu Ala Leu Asp Gly His Leu Tyr Ala 
                405                 410                 415     


Val Gly Gly Glu Cys Leu Leu Ser Val Glu Arg Tyr Asp Pro Arg Ala 
            420                 425                 430         


Asp Arg Trp Ala Pro Val Ala Pro Leu Pro Arg Gly Ala Phe Ala Val 
        435                 440                 445             


Ala His Glu Ala Thr Thr Cys His Gly Glu Ile Tyr Val Ser Gly Gly 
    450                 455                 460                 


Ser Leu Phe Tyr Arg Leu Leu Lys Tyr Asp Pro Arg Arg Asp Glu Trp 
465                 470                 475                 480 


Gln Glu Cys Pro Cys Ser Ser Ser Arg Glu Arg Ser Ala Asp Met Val 
                485                 490                 495     


Ala Leu Asp Gly Phe Ile Tyr Arg Phe Asp Leu Ser Gly Ser Arg Gly 
            500                 505                 510         


Glu Ala Gln Ala Ala Gly Pro Ser Gly Val Ser Val Ser Arg Tyr His 
        515                 520                 525             


Cys Leu Ala Lys Gln Trp Ser Pro Cys Val Ala Pro Leu Arg Leu Pro 
    530                 535                 540                 


Gly Gly Pro Thr Gly Leu Gln Pro Phe Arg Cys Ala Ala Leu Asp Gly 
545                 550                 555                 560 


Ala Ile Tyr Cys Val Ser Arg Ala Gly Thr Trp Arg Phe Gln Pro Ala 
                565                 570                 575     


Arg Glu Gly Glu Ala Gly Gly Asp Ala Gly Gln Gly Gly Gly Phe Glu 
            580                 585                 590         


Ala Leu Gly Ala Pro Leu Asp Val Arg Gly Val Leu Ile Pro Phe Ala 
        595                 600                 605             


Leu Ser Leu Pro Glu Lys Pro Pro Arg Gly Glu Gln Gly Ala Pro 
    610                 615                 620             


<210>  5706
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KBTBD13__Homo_sapiens__NP_001094832

<400>  5706

Met Ala Arg Gly Pro Gln Thr Leu Val Gln Val Trp Val Gly Gly Gln 
1               5                   10                  15      


Leu Phe Gln Ala Asp Arg Ala Leu Leu Val Glu His Cys Gly Phe Phe 
            20                  25                  30          


Arg Gly Leu Phe Arg Ser Gly Met Arg Glu Thr Arg Ala Ala Glu Val 
        35                  40                  45              


Arg Leu Gly Val Leu Ser Ala Gly Gly Phe Arg Ala Thr Leu Gln Val 
    50                  55                  60                  


Leu Arg Gly Asp Arg Pro Ala Leu Ala Ala Glu Asp Glu Leu Leu Gln 
65                  70                  75                  80  


Ala Val Glu Cys Ala Ala Phe Leu Gln Ala Pro Ala Leu Ala Arg Phe 
                85                  90                  95      


Leu Glu His Asn Leu Thr Ser Asp Asn Cys Ala Leu Leu Cys Asp Ala 
            100                 105                 110         


Ala Ala Ala Phe Gly Leu Arg Asp Val Phe His Ser Ala Ala Leu Phe 
        115                 120                 125             


Ile Cys Asp Gly Glu Arg Glu Leu Ala Ala Glu Leu Ala Leu Pro Glu 
    130                 135                 140                 


Ala Arg Ala Tyr Val Ala Ala Leu Arg Pro Ser Ser Tyr Ala Ala Val 
145                 150                 155                 160 


Ser Thr His Thr Pro Ala Pro Gly Phe Leu Glu Asp Ala Ser Arg Thr 
                165                 170                 175     


Leu Cys Tyr Leu Asp Glu Glu Glu Asp Ala Trp Arg Thr Leu Ala Ala 
            180                 185                 190         


Leu Pro Leu Glu Ala Ser Thr Leu Leu Ala Gly Val Ala Thr Leu Gly 
        195                 200                 205             


Asn Lys Leu Tyr Ile Val Gly Gly Val Arg Gly Ala Ser Lys Glu Val 
    210                 215                 220                 


Val Glu Leu Gly Phe Cys Tyr Asp Pro Asp Gly Gly Thr Trp His Glu 
225                 230                 235                 240 


Phe Pro Ser Pro His Gln Pro Arg Tyr Asp Thr Ala Leu Ala Gly Phe 
                245                 250                 255     


Asp Gly Arg Leu Tyr Ala Ile Gly Gly Glu Phe Gln Arg Thr Pro Ile 
            260                 265                 270         


Ser Ser Val Glu Arg Tyr Asp Pro Ala Ala Gly Cys Trp Ser Phe Val 
        275                 280                 285             


Ala Asp Leu Pro Gln Pro Ala Ala Gly Val Pro Cys Ala Gln Ala Cys 
    290                 295                 300                 


Gly Arg Leu Phe Val Cys Leu Trp Arg Pro Ala Asp Thr Thr Ala Val 
305                 310                 315                 320 


Val Glu Tyr Ala Val Arg Thr Asp Ala Trp Leu Pro Val Ala Glu Leu 
                325                 330                 335     


Arg Arg Pro Gln Ser Tyr Gly His Cys Met Val Ala His Arg Asp Ser 
            340                 345                 350         


Leu Tyr Val Val Arg Asn Gly Pro Ser Asp Asp Phe Leu His Cys Ala 
        355                 360                 365             


Ile Asp Cys Leu Asn Leu Ala Thr Gly Gln Trp Thr Ala Leu Pro Gly 
    370                 375                 380                 


Gln Phe Val Asn Ser Lys Gly Ala Leu Phe Thr Ala Val Val Arg Gly 
385                 390                 395                 400 


Asp Thr Val Tyr Thr Val Asn Arg Met Phe Thr Leu Leu Tyr Ala Ile 
                405                 410                 415     


Glu Gly Gly Thr Trp Arg Leu Leu Arg Glu Lys Ala Gly Phe Pro Arg 
            420                 425                 430         


Pro Gly Ser Leu Gln Thr Phe Leu Leu Arg Leu Pro Pro Gly Ala Pro 
        435                 440                 445             


Gly Pro Val Thr Ser Thr Thr Ala Glu Leu 
    450                 455             


<210>  5707
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KBTBD8__Homo_sapiens__NP_115894

<400>  5707

Met Ala Ala Ser Ala Asp Leu Ser Lys Ser Ser Pro Thr Pro Asn Gly 
1               5                   10                  15      


Ile Pro Ser Ser Asp Pro Ala Ser Asp Ala Met Asp Pro Phe His Ala 
            20                  25                  30          


Cys Ser Ile Leu Lys Gln Leu Lys Thr Met Tyr Asp Glu Gly Gln Leu 
        35                  40                  45              


Thr Asp Ile Val Val Glu Val Asp His Gly Lys Thr Phe Ser Cys His 
    50                  55                  60                  


Arg Asn Val Leu Ala Ala Ile Ser Pro Tyr Phe Arg Ser Met Phe Thr 
65                  70                  75                  80  


Ser Gly Leu Thr Glu Ser Thr Gln Lys Glu Val Arg Ile Val Gly Val 
                85                  90                  95      


Glu Ala Glu Ser Met Asp Leu Val Leu Asn Tyr Ala Tyr Thr Ser Arg 
            100                 105                 110         


Val Ile Leu Thr Glu Ala Asn Val Gln Ala Leu Phe Thr Ala Ala Ser 
        115                 120                 125             


Ile Phe Gln Ile Pro Ser Ile Gln Asp Gln Cys Ala Lys Tyr Met Ile 
    130                 135                 140                 


Ser His Leu Asp Pro Gln Asn Ser Ile Gly Val Phe Ile Phe Ala Asp 
145                 150                 155                 160 


His Tyr Gly His Gln Glu Leu Gly Asp Arg Ser Lys Glu Tyr Ile Arg 
                165                 170                 175     


Lys Lys Phe Leu Cys Val Thr Lys Glu Gln Glu Phe Leu Gln Leu Thr 
            180                 185                 190         


Lys Asp Gln Leu Ile Ser Ile Leu Asp Ser Asp Asp Leu Asn Val Asp 
        195                 200                 205             


Arg Glu Glu His Val Tyr Glu Ser Ile Ile Arg Trp Phe Glu His Glu 
    210                 215                 220                 


Gln Asn Glu Arg Glu Val His Leu Pro Glu Ile Phe Ala Lys Cys Ile 
225                 230                 235                 240 


Arg Phe Pro Leu Met Glu Asp Thr Phe Ile Glu Lys Ile Pro Pro Gln 
                245                 250                 255     


Phe Ala Gln Ala Ile Ala Lys Ser Cys Val Glu Lys Gly Pro Ser Asn 
            260                 265                 270         


Thr Asn Gly Cys Thr Gln Arg Leu Gly Met Thr Ala Ser Glu Met Ile 
        275                 280                 285             


Ile Cys Phe Asp Ala Ala His Lys His Ser Gly Lys Lys Gln Thr Val 
    290                 295                 300                 


Pro Cys Leu Asp Ile Val Thr Gly Arg Val Phe Lys Leu Cys Lys Pro 
305                 310                 315                 320 


Pro Asn Asp Leu Arg Glu Val Gly Ile Leu Val Ser Pro Asp Asn Asp 
                325                 330                 335     


Ile Tyr Ile Ala Gly Gly Tyr Arg Pro Ser Ser Ser Glu Val Ser Ile 
            340                 345                 350         


Asp His Lys Ala Glu Asn Asp Phe Trp Met Tyr Asp His Ser Thr Asn 
        355                 360                 365             


Arg Trp Leu Ser Lys Pro Ser Leu Leu Arg Ala Arg Ile Gly Cys Lys 
    370                 375                 380                 


Leu Val Tyr Cys Cys Gly Lys Met Tyr Ala Ile Gly Gly Arg Val Tyr 
385                 390                 395                 400 


Glu Gly Asp Gly Arg Asn Ser Leu Lys Ser Val Glu Cys Tyr Asp Ser 
                405                 410                 415     


Arg Glu Asn Cys Trp Thr Thr Val Cys Ala Met Pro Val Ala Met Glu 
            420                 425                 430         


Phe His Asn Ala Val Glu Tyr Lys Glu Lys Ile Tyr Val Leu Gln Gly 
        435                 440                 445             


Glu Phe Phe Leu Phe Tyr Glu Pro Gln Lys Asp Tyr Trp Gly Phe Leu 
    450                 455                 460                 


Thr Pro Met Thr Val Pro Arg Ile Gln Gly Leu Ala Ala Val Tyr Lys 
465                 470                 475                 480 


Asp Ser Ile Tyr Tyr Ile Ala Gly Thr Cys Gly Asn His Gln Arg Met 
                485                 490                 495     


Phe Thr Val Glu Ala Tyr Asp Ile Glu Leu Asn Lys Trp Thr Arg Lys 
            500                 505                 510         


Lys Asp Phe Pro Cys Asp Gln Ser Ile Asn Pro Tyr Leu Lys Leu Val 
        515                 520                 525             


Leu Phe Gln Asn Lys Leu His Leu Phe Val Arg Ala Thr Gln Val Thr 
    530                 535                 540                 


Val Glu Glu His Val Phe Arg Thr Ser Arg Lys Asn Ser Leu Tyr Gln 
545                 550                 555                 560 


Tyr Asp Asp Ile Ala Asp Gln Trp Met Lys Val Tyr Glu Thr Pro Asp 
                565                 570                 575     


Arg Leu Trp Asp Leu Gly Arg His Phe Glu Cys Ala Val Ala Lys Leu 
            580                 585                 590         


Tyr Pro Gln Cys Leu Gln Lys Val Leu 
        595                 600     


<210>  5708
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCMF1__Homo_sapiens__NP_064507

<400>  5708

Met Ser Arg His Glu Gly Val Ser Cys Asp Ala Cys Leu Lys Gly Asn 
1               5                   10                  15      


Phe Arg Gly Arg Arg Tyr Lys Cys Leu Ile Cys Tyr Asp Tyr Asp Leu 
            20                  25                  30          


Cys Ala Ser Cys Tyr Glu Ser Gly Ala Thr Thr Thr Arg His Thr Thr 
        35                  40                  45              


Asp His Pro Met Gln Cys Ile Leu Thr Arg Val Asp Phe Asp Leu Tyr 
    50                  55                  60                  


Tyr Gly Gly Glu Ala Phe Ser Val Glu Gln Pro Gln Ser Phe Thr Cys 
65                  70                  75                  80  


Pro Tyr Cys Gly Lys Met Gly Tyr Thr Glu Thr Ser Leu Gln Glu His 
                85                  90                  95      


Val Thr Ser Glu His Ala Glu Thr Ser Thr Glu Val Ile Cys Pro Ile 
            100                 105                 110         


Cys Ala Ala Leu Pro Gly Gly Asp Pro Asn His Val Thr Asp Asp Phe 
        115                 120                 125             


Ala Ala His Leu Thr Leu Glu His Arg Ala Pro Arg Asp Leu Asp Glu 
    130                 135                 140                 


Ser Ser Gly Val Arg His Val Arg Arg Met Phe His Pro Gly Arg Gly 
145                 150                 155                 160 


Leu Gly Gly Pro Arg Ala Arg Arg Ser Asn Met His Phe Thr Ser Ser 
                165                 170                 175     


Ser Thr Gly Gly Leu Ser Ser Ser Gln Ser Ser Tyr Ser Pro Ser Asn 
            180                 185                 190         


Arg Glu Ala Met Asp Pro Ile Ala Glu Leu Leu Ser Gln Leu Ser Gly 
        195                 200                 205             


Val Arg Arg Ser Ala Gly Gly Gln Leu Asn Ser Ser Gly Pro Ser Ala 
    210                 215                 220                 


Ser Gln Leu Gln Gln Leu Gln Met Gln Leu Gln Leu Glu Arg Gln His 
225                 230                 235                 240 


Ala Gln Ala Ala Arg Gln Gln Leu Glu Thr Ala Arg Asn Ala Thr Arg 
                245                 250                 255     


Arg Thr Asn Thr Ser Ser Val Thr Thr Thr Ile Thr Gln Ser Thr Ala 
            260                 265                 270         


Thr Thr Asn Ile Ala Asn Thr Glu Ser Ser Gln Gln Thr Leu Gln Asn 
        275                 280                 285             


Ser Gln Phe Leu Leu Thr Arg Leu Asn Asp Pro Lys Met Ser Glu Thr 
    290                 295                 300                 


Glu Arg Gln Ser Met Glu Ser Glu Arg Ala Asp Arg Ser Leu Phe Val 
305                 310                 315                 320 


Gln Glu Leu Leu Leu Ser Thr Leu Val Arg Glu Glu Ser Ser Ser Ser 
                325                 330                 335     


Asp Glu Asp Asp Arg Gly Glu Met Ala Asp Phe Gly Ala Met Gly Cys 
            340                 345                 350         


Val Asp Ile Met Pro Leu Asp Val Ala Leu Glu Asn Leu Asn Leu Lys 
        355                 360                 365             


Glu Ser Asn Lys Gly Asn Glu Pro Pro Pro Pro Pro Leu 
    370                 375                 380     


<210>  5709
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNA1__Homo_sapiens__NP_000208

<400>  5709

Met Thr Val Met Ser Gly Glu Asn Val Asp Glu Ala Ser Ala Ala Pro 
1               5                   10                  15      


Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
            20                  25                  30          


His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
        35                  40                  45              


Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
    50                  55                  60                  


Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
65                  70                  75                  80  


Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                85                  90                  95      


Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
            100                 105                 110         


Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
        115                 120                 125             


Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
    130                 135                 140                 


Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
145                 150                 155                 160 


Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                165                 170                 175     


Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
            180                 185                 190         


Lys Asp Asp Lys Asp Phe Thr Gly Thr Val His Arg Ile Asp Asn Thr 
        195                 200                 205             


Thr Val Ile Tyr Asn Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
    210                 215                 220                 


Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
225                 230                 235                 240 


Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                245                 250                 255     


Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
            260                 265                 270         


Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
        275                 280                 285             


Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
    290                 295                 300                 


Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
305                 310                 315                 320 


Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                325                 330                 335     


Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
            340                 345                 350         


Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
        355                 360                 365             


Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
    370                 375                 380                 


Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
385                 390                 395                 400 


Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                405                 410                 415     


Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
            420                 425                 430         


Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
        435                 440                 445             


Met Ser Lys Ser Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
    450                 455                 460                 


Ile Ala His Tyr Arg Gln Val Asn Ile Arg Thr Ala Asn Cys Thr Thr 
465                 470                 475                 480 


Ala Asn Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                485                 490                 495 


<210>  5710
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNA4__Homo_sapiens__NP_002224

<400>  5710

Met Glu Val Ala Met Val Ser Ala Glu Ser Ser Gly Cys Asn Ser His 
1               5                   10                  15      


Met Pro Tyr Gly Tyr Ala Ala Gln Ala Arg Ala Arg Glu Arg Glu Arg 
            20                  25                  30          


Leu Ala His Ser Arg Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Thr 
        35                  40                  45              


Ala Ala Val Glu Gly Ser Gly Gly Ser Gly Gly Gly Ser His His His 
    50                  55                  60                  


His Gln Ser Arg Gly Ala Cys Thr Ser His Asp Pro Gln Ser Ser Arg 
65                  70                  75                  80  


Gly Ser Arg Arg Arg Arg Arg Gln Arg Ser Glu Lys Lys Lys Ala His 
                85                  90                  95      


Tyr Arg Gln Ser Ser Phe Pro His Cys Ser Asp Leu Met Pro Ser Gly 
            100                 105                 110         


Ser Glu Glu Lys Ile Leu Arg Glu Leu Ser Glu Glu Glu Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Arg Phe Tyr Tyr Ser Glu 
    130                 135                 140                 


Asp Asp His Gly Asp Glu Cys Ser Tyr Thr Asp Leu Leu Pro Gln Asp 
145                 150                 155                 160 


Glu Gly Gly Gly Gly Tyr Ser Ser Val Arg Tyr Ser Asp Cys Cys Glu 
                165                 170                 175     


Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln Met Lys 
            180                 185                 190         


Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Glu Lys Arg 
        195                 200                 205             


Thr Gln Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg Asn 
    210                 215                 220                 


Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg 
225                 230                 235                 240 


Leu Lys Arg Pro Val Asn Val Pro Phe Asp Ile Phe Thr Glu Glu Val 
                245                 250                 255     


Lys Phe Tyr Gln Leu Gly Glu Glu Ala Leu Leu Lys Phe Arg Glu Asp 
            260                 265                 270         


Glu Gly Phe Val Arg Glu Glu Glu Asp Arg Ala Leu Pro Glu Asn Glu 
        275                 280                 285             


Phe Lys Lys Gln Ile Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Ser 
    290                 295                 300                 


Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser 
305                 310                 315                 320 


Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg Asp Asp Arg 
                325                 330                 335     


Asp Leu Val Met Ala Leu Ser Ala Gly Gly His Gly Gly Leu Leu Asn 
            340                 345                 350         


Asp Thr Ser Ala Pro His Leu Glu Asn Ser Gly His Thr Ile Phe Asn 
        355                 360                 365             


Asp Pro Phe Phe Ile Val Glu Thr Val Cys Ile Val Trp Phe Ser Phe 
    370                 375                 380                 


Glu Phe Val Val Arg Cys Phe Ala Cys Pro Ser Gln Ala Leu Phe Phe 
385                 390                 395                 400 


Lys Asn Ile Met Asn Ile Ile Asp Ile Val Ser Ile Leu Pro Tyr Phe 
                405                 410                 415     


Ile Thr Leu Gly Thr Asp Leu Ala Gln Gln Gln Gly Gly Gly Asn Gly 
            420                 425                 430         


Gln Gln Gln Gln Ala Met Ser Phe Ala Ile Leu Arg Ile Ile Arg Leu 
        435                 440                 445             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    450                 455                 460                 


Gln Ile Leu Gly His Thr Leu Arg Ala Ser Met Arg Glu Leu Gly Leu 
465                 470                 475                 480 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                485                 490                 495     


Tyr Phe Ala Glu Ala Asp Glu Pro Thr Thr His Phe Gln Ser Ile Pro 
            500                 505                 510         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        515                 520                 525             


Asp Met Lys Pro Ile Thr Val Gly Gly Lys Ile Val Gly Ser Leu Cys 
    530                 535                 540                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
545                 550                 555                 560 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Asn Glu Glu Gln 
                565                 570                 575     


Thr Gln Leu Thr Gln Asn Ala Val Ser Cys Pro Tyr Leu Pro Ser Asn 
            580                 585                 590         


Leu Leu Lys Lys Phe Arg Ser Ser Thr Ser Ser Ser Leu Gly Asp Lys 
        595                 600                 605             


Ser Glu Tyr Leu Glu Met Glu Glu Gly Val Lys Glu Ser Leu Cys Ala 
    610                 615                 620                 


Lys Glu Glu Lys Cys Gln Gly Lys Gly Asp Asp Ser Glu Thr Asp Lys 
625                 630                 635                 640 


Asn Asn Cys Ser Asn Ala Lys Ala Val Glu Thr Asp Val 
                645                 650             


<210>  5711
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNA5__Homo_sapiens__NP_002225

<400>  5711

Met Glu Ile Ala Leu Val Pro Leu Glu Asn Gly Gly Ala Met Thr Val 
1               5                   10                  15      


Arg Gly Gly Asp Glu Ala Arg Ala Gly Cys Gly Gln Ala Thr Gly Gly 
            20                  25                  30          


Glu Leu Gln Cys Pro Pro Thr Ala Gly Leu Ser Asp Gly Pro Lys Glu 
        35                  40                  45              


Pro Ala Pro Lys Gly Arg Gly Ala Gln Arg Asp Ala Asp Ser Gly Val 
    50                  55                  60                  


Arg Pro Leu Pro Pro Leu Pro Asp Pro Gly Val Arg Pro Leu Pro Pro 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Arg Pro Arg Arg Pro Pro Pro Glu Asp Glu 
                85                  90                  95      


Glu Glu Glu Gly Asp Pro Gly Leu Gly Thr Val Glu Asp Gln Ala Leu 
            100                 105                 110         


Gly Thr Ala Ser Leu His His Gln Arg Val His Ile Asn Ile Ser Gly 
        115                 120                 125             


Leu Arg Phe Glu Thr Gln Leu Gly Thr Leu Ala Gln Phe Pro Asn Thr 
    130                 135                 140                 


Leu Leu Gly Asp Pro Ala Lys Arg Leu Arg Tyr Phe Asp Pro Leu Arg 
145                 150                 155                 160 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Gly Ile Leu 
                165                 170                 175     


Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Ser 
            180                 185                 190         


Leu Asp Val Phe Ala Asp Glu Ile Arg Phe Tyr Gln Leu Gly Asp Glu 
        195                 200                 205             


Ala Met Glu Arg Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu 
    210                 215                 220                 


Lys Pro Leu Pro Arg Asn Glu Phe Gln Arg Gln Val Trp Leu Ile Phe 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ser Gly Ser Ala Arg Ala Ile Ala Ile Val Ser 
                245                 250                 255     


Val Leu Val Ile Leu Ile Ser Ile Ile Thr Phe Cys Leu Glu Thr Leu 
            260                 265                 270         


Pro Glu Phe Arg Asp Glu Arg Glu Leu Leu Arg His Pro Pro Ala Pro 
        275                 280                 285             


His Gln Pro Pro Ala Pro Ala Pro Gly Ala Asn Gly Ser Gly Val Met 
    290                 295                 300                 


Ala Pro Pro Ser Gly Pro Thr Val Ala Pro Leu Leu Pro Arg Thr Leu 
305                 310                 315                 320 


Ala Asp Pro Phe Phe Ile Val Glu Thr Thr Cys Val Ile Trp Phe Thr 
                325                 330                 335     


Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys Ala Gly Phe 
            340                 345                 350         


Ser Arg Asn Ile Met Asn Ile Ile Asp Val Val Ala Ile Phe Pro Tyr 
        355                 360                 365             


Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Gln Gln Pro Gly Gly Gly 
    370                 375                 380                 


Gly Gly Gly Gln Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg 
385                 390                 395                 400 


Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His 
                405                 410                 415     


Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr Leu Gln Ala Ser Met Arg 
            420                 425                 430         


Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe 
        435                 440                 445             


Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp Asn Gln Gly Thr His Phe 
    450                 455                 460                 


Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr 
465                 470                 475                 480 


Val Gly Tyr Gly Asp Met Arg Pro Ile Thr Val Gly Gly Lys Ile Val 
                485                 490                 495     


Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val 
            500                 505                 510         


Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Asp 
        515                 520                 525             


His Glu Glu Pro Ala Val Leu Lys Glu Glu Gln Gly Thr Gln Ser Gln 
    530                 535                 540                 


Gly Pro Gly Leu Asp Arg Gly Val Gln Arg Lys Val Ser Gly Ser Arg 
545                 550                 555                 560 


Gly Ser Phe Cys Lys Ala Gly Gly Thr Leu Glu Asn Ala Asp Ser Ala 
                565                 570                 575     


Arg Arg Gly Ser Cys Pro Leu Glu Lys Cys Asn Val Lys Ala Lys Ser 
            580                 585                 590         


Asn Val Asp Leu Arg Arg Ser Leu Tyr Ala Leu Cys Leu Asp Thr Ser 
        595                 600                 605             


Arg Glu Thr Asp Leu 
    610             


<210>  5712
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNA6__Homo_sapiens__XP_011519257

<400>  5712

Met Arg Ser Glu Lys Ser Leu Thr Leu Ala Ala Pro Gly Glu Val Arg 
1               5                   10                  15      


Gly Pro Glu Gly Glu Gln Gln Asp Ala Gly Asp Phe Pro Glu Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Cys Cys Ser Ser Glu Arg Leu Val Ile Asn Ile Ser 
        35                  40                  45              


Gly Leu Arg Phe Glu Thr Gln Leu Arg Thr Leu Ser Leu Phe Pro Asp 
    50                  55                  60                  


Thr Leu Leu Gly Asp Pro Gly Arg Arg Val Arg Phe Phe Asp Pro Leu 
65                  70                  75                  80  


Arg Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile 
                85                  90                  95      


Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val 
            100                 105                 110         


Pro Leu Asp Ile Phe Leu Glu Glu Ile Arg Phe Tyr Gln Leu Gly Asp 
        115                 120                 125             


Glu Ala Leu Ala Ala Phe Arg Glu Asp Glu Gly Cys Leu Pro Glu Gly 
    130                 135                 140                 


Gly Glu Asp Glu Lys Pro Leu Pro Ser Gln Pro Phe Gln Arg Gln Val 
145                 150                 155                 160 


Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
                165                 170                 175     


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            180                 185                 190         


Leu Glu Thr Leu Pro Gln Phe Arg Val Asp Gly Arg Gly Gly Asn Asn 
        195                 200                 205             


Gly Gly Val Ser Arg Val Ser Pro Val Ser Arg Gly Ser Gln Glu Glu 
    210                 215                 220                 


Glu Glu Asp Glu Asp Asp Ser Tyr Thr Phe His His Gly Ile Thr Pro 
225                 230                 235                 240 


Gly Glu Met Gly Thr Gly Gly Ser Ser Ser Leu Ser Thr Leu Gly Gly 
                245                 250                 255     


Ser Phe Phe Thr Asp Pro Phe Phe Leu Val Glu Thr Leu Cys Ile Val 
            260                 265                 270         


Trp Phe Thr Phe Glu Leu Leu Val Arg Phe Ser Ala Cys Pro Ser Lys 
        275                 280                 285             


Pro Ala Phe Phe Arg Asn Ile Met Asn Ile Ile Asp Leu Val Ala Ile 
    290                 295                 300                 


Phe Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Val Gln Gln Gln Glu 
305                 310                 315                 320 


Gln Gln Pro Ala Ser Gly Gly Gly Gly Gln Asn Gly Gln Gln Ala Met 
                325                 330                 335     


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
            340                 345                 350         


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr 
        355                 360                 365             


Leu Gln Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
    370                 375                 380                 


Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp 
385                 390                 395                 400 


Asp Asp Asp Ser Leu Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala 
                405                 410                 415     


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Met Thr 
            420                 425                 430         


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
        435                 440                 445             


Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe 
    450                 455                 460                 


Tyr His Arg Glu Thr Glu Gln Glu Glu Gln Gly Gln Tyr Thr His Val 
465                 470                 475                 480 


Thr Cys Gly Gln Pro Ala Pro Asp Leu Arg Ala Thr Asp Asn Gly Leu 
                485                 490                 495     


Gly Lys Pro Asp Phe Pro Glu Ala Asn Arg Glu Arg Arg Pro Ser Tyr 
            500                 505                 510         


Leu Pro Thr Pro His Arg Ala Tyr Ala Glu Lys Arg Met Leu Thr Glu 
        515                 520                 525             


Val 
    


<210>  5713
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNA7__Homo_sapiens__NP_114092

<400>  5713

Met Glu Pro Arg Cys Pro Pro Pro Cys Gly Cys Cys Glu Arg Leu Val 
1               5                   10                  15      


Leu Asn Val Ala Gly Leu Arg Phe Glu Thr Arg Ala Arg Thr Leu Gly 
            20                  25                  30          


Arg Phe Pro Asp Thr Leu Leu Gly Asp Pro Ala Arg Arg Gly Arg Phe 
        35                  40                  45              


Tyr Asp Asp Ala Arg Arg Glu Tyr Phe Phe Asp Arg His Arg Pro Ser 
    50                  55                  60                  


Phe Asp Ala Val Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg 
65                  70                  75                  80  


Pro Ala His Val Pro Leu Asp Val Phe Leu Glu Glu Val Ala Phe Tyr 
                85                  90                  95      


Gly Leu Gly Ala Ala Ala Leu Ala Arg Leu Arg Glu Asp Glu Gly Cys 
            100                 105                 110         


Pro Val Pro Pro Glu Arg Pro Leu Pro Arg Arg Ala Phe Ala Arg Gln 
        115                 120                 125             


Leu Trp Leu Leu Phe Glu Phe Pro Glu Ser Ser Gln Ala Ala Arg Val 
    130                 135                 140                 


Leu Ala Val Val Ser Val Leu Val Ile Leu Val Ser Ile Val Val Phe 
145                 150                 155                 160 


Cys Leu Glu Thr Leu Pro Asp Phe Arg Asp Asp Arg Asp Gly Thr Gly 
                165                 170                 175     


Leu Ala Ala Ala Ala Ala Ala Gly Pro Phe Pro Ala Pro Leu Asn Gly 
            180                 185                 190         


Ser Ser Gln Met Pro Gly Asn Pro Pro Arg Leu Pro Phe Asn Asp Pro 
        195                 200                 205             


Phe Phe Val Val Glu Thr Leu Cys Ile Cys Trp Phe Ser Phe Glu Leu 
    210                 215                 220                 


Leu Val Arg Leu Leu Val Cys Pro Ser Lys Ala Ile Phe Phe Lys Asn 
225                 230                 235                 240 


Val Met Asn Leu Ile Asp Phe Val Ala Ile Leu Pro Tyr Phe Val Ala 
                245                 250                 255     


Leu Gly Thr Glu Leu Ala Arg Gln Arg Gly Val Gly Gln Gln Ala Met 
            260                 265                 270         


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
        275                 280                 285             


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr 
    290                 295                 300                 


Leu Arg Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
305                 310                 315                 320 


Ile Gly Val Val Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Val Asp 
                325                 330                 335     


Arg Val Asp Ser His Phe Thr Ser Ile Pro Glu Ser Phe Trp Trp Ala 
            340                 345                 350         


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Ala Pro Val Thr 
        355                 360                 365             


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
    370                 375                 380                 


Thr Ile Ser Leu Pro Val Pro Val Ile Val Ser Asn Phe Ser Tyr Phe 
385                 390                 395                 400 


Tyr His Arg Glu Thr Glu Gly Glu Glu Ala Gly Met Phe Ser His Val 
                405                 410                 415     


Asp Met Gln Pro Cys Gly Pro Leu Glu Gly Lys Ala Asn Gly Gly Leu 
            420                 425                 430         


Val Asp Gly Glu Val Pro Glu Leu Pro Pro Pro Leu Trp Ala Pro Pro 
        435                 440                 445             


Gly Lys His Leu Val Thr Glu Val 
    450                 455     


<210>  5714
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNAB1__Homo_sapiens__NP_003462

<400>  5714

Met His Leu Tyr Lys Pro Ala Cys Ala Asp Ile Pro Ser Pro Lys Leu 
1               5                   10                  15      


Gly Leu Pro Lys Ser Ser Glu Ser Ala Leu Lys Cys Arg Trp His Leu 
            20                  25                  30          


Ala Val Thr Lys Thr Gln Pro Gln Ala Ala Cys Lys Pro Val Arg Pro 
        35                  40                  45              


Ser Gly Ala Ala Glu Gln Lys Tyr Val Glu Lys Phe Leu Arg Val His 
    50                  55                  60                  


Gly Ile Ser Leu Gln Glu Thr Thr Arg Ala Glu Thr Gly Met Ala Tyr 
65                  70                  75                  80  


Arg Asn Leu Gly Lys Ser Gly Leu Arg Val Ser Cys Leu Gly Leu Gly 
                85                  90                  95      


Thr Trp Val Thr Phe Gly Gly Gln Ile Ser Asp Glu Val Ala Glu Arg 
            100                 105                 110         


Leu Met Thr Ile Ala Tyr Glu Ser Gly Val Asn Leu Phe Asp Thr Ala 
        115                 120                 125             


Glu Val Tyr Ala Ala Gly Lys Ala Glu Val Ile Leu Gly Ser Ile Ile 
    130                 135                 140                 


Lys Lys Lys Gly Trp Arg Arg Ser Ser Leu Val Ile Thr Thr Lys Leu 
145                 150                 155                 160 


Tyr Trp Gly Gly Lys Ala Glu Thr Glu Arg Gly Leu Ser Arg Lys His 
                165                 170                 175     


Ile Ile Glu Gly Leu Lys Gly Ser Leu Gln Arg Leu Gln Leu Glu Tyr 
            180                 185                 190         


Val Asp Val Val Phe Ala Asn Arg Pro Asp Ser Asn Thr Pro Met Glu 
        195                 200                 205             


Glu Ile Val Arg Ala Met Thr His Val Ile Asn Gln Gly Met Ala Met 
    210                 215                 220                 


Tyr Trp Gly Thr Ser Arg Trp Ser Ala Met Glu Ile Met Glu Ala Tyr 
225                 230                 235                 240 


Ser Val Ala Arg Gln Phe Asn Met Ile Pro Pro Val Cys Glu Gln Ala 
                245                 250                 255     


Glu Tyr His Leu Phe Gln Arg Glu Lys Val Glu Val Gln Leu Pro Glu 
            260                 265                 270         


Leu Tyr His Lys Ile Gly Val Gly Ala Met Thr Trp Ser Pro Leu Ala 
        275                 280                 285             


Cys Gly Ile Ile Ser Gly Lys Tyr Gly Asn Gly Val Pro Glu Ser Ser 
    290                 295                 300                 


Arg Ala Ser Leu Lys Cys Tyr Gln Trp Leu Lys Glu Arg Ile Val Ser 
305                 310                 315                 320 


Glu Glu Gly Arg Lys Gln Gln Asn Lys Leu Lys Asp Leu Ser Pro Ile 
                325                 330                 335     


Ala Glu Arg Leu Gly Cys Thr Leu Pro Gln Leu Ala Val Ala Trp Cys 
            340                 345                 350         


Leu Arg Asn Glu Gly Val Ser Ser Val Leu Leu Gly Ser Ser Thr Pro 
        355                 360                 365             


Glu Gln Leu Ile Glu Asn Leu Gly Ala Ile Gln Val Leu Pro Lys Met 
    370                 375                 380                 


Thr Ser His Val Val Asn Glu Ile Asp Asn Ile Leu Arg Asn Lys Pro 
385                 390                 395                 400 


Tyr Ser Lys Lys Asp Tyr Arg Ser 
                405             


<210>  5715
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNAB2__Homo_sapiens__XP_011540622

<400>  5715

Met Leu Ser Met Thr Tyr Ser Glu Ser Leu Arg Ser Val Ser Ser Arg 
1               5                   10                  15      


Cys His Ser Glu Trp Ala Leu His Pro Val Arg Gln Thr Asp Thr Leu 
            20                  25                  30          


Glu Leu Gln Arg Leu Arg Glu Val Arg Ala Ala Ala Gln Ala Arg Asn 
        35                  40                  45              


Met Glu Ser Phe Leu Arg Met His Gly Leu Ser Leu Asp Gly Cys Thr 
    50                  55                  60                  


Ala Gln Arg Thr Gly Met Lys Tyr Arg Asn Leu Gly Lys Ser Gly Leu 
65                  70                  75                  80  


Arg Val Ser Cys Leu Gly Leu Gly Thr Trp Val Thr Phe Gly Gly Gln 
                85                  90                  95      


Ile Thr Asp Glu Met Ala Glu Gln Leu Met Thr Leu Ala Tyr Asp Asn 
            100                 105                 110         


Gly Ile Asn Leu Phe Asp Thr Ala Glu Val Tyr Ala Ala Gly Lys Ala 
        115                 120                 125             


Glu Val Val Leu Gly Asn Ile Ile Lys Lys Lys Gly Trp Arg Arg Ser 
    130                 135                 140                 


Ser Leu Val Ile Thr Thr Lys Ile Phe Trp Gly Gly Lys Ala Glu Thr 
145                 150                 155                 160 


Glu Arg Gly Leu Ser Arg Lys His Ile Ile Glu Gly Leu Lys Ala Ser 
                165                 170                 175     


Leu Glu Arg Leu Gln Leu Glu Tyr Val Asp Val Val Phe Ala Asn Arg 
            180                 185                 190         


Pro Asp Pro Asn Thr Pro Met Glu Glu Thr Val Arg Ala Met Thr His 
        195                 200                 205             


Val Ile Asn Gln Gly Met Ala Met Tyr Trp Gly Thr Ser Arg Trp Ser 
    210                 215                 220                 


Ser Met Glu Ile Met Glu Ala Tyr Ser Val Ala Arg Gln Phe Asn Leu 
225                 230                 235                 240 


Thr Pro Pro Ile Cys Glu Gln Ala Glu Tyr His Met Phe Gln Arg Glu 
                245                 250                 255     


Lys Val Glu Val Gln Leu Pro Glu Leu Phe His Lys Ile Gly Val Gly 
            260                 265                 270         


Ala Met Thr Trp Ser Pro Leu Ala Cys Gly Ile Val Ser Gly Lys Tyr 
        275                 280                 285             


Asp Ser Gly Ile Pro Pro Tyr Ser Arg Ala Ser Leu Lys Gly Tyr Gln 
    290                 295                 300                 


Trp Leu Lys Asp Lys Ile Leu Ser Glu Glu Gly Arg Arg Gln Gln Ala 
305                 310                 315                 320 


Lys Leu Lys Glu Leu Gln Ala Ile Ala Glu Arg Leu Gly Cys Thr Leu 
                325                 330                 335     


Pro Gln Leu Ala Ile Ala Trp Cys Leu Arg Asn Glu Gly Val Ser Ser 
            340                 345                 350         


Val Leu Leu Gly Ala Ser Asn Ala Asp Gln Leu Met Glu Asn Ile Gly 
        355                 360                 365             


Ala Ile Gln Val Leu Pro Lys Leu Ser Ser Ser Ile Ile His Glu Ile 
    370                 375                 380                 


Asp Ser Ile Leu Gly Asn Lys Pro Tyr Ser Lys Lys Asp Tyr Arg Ser 
385                 390                 395                 400 


<210>  5716
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNAB3__Homo_sapiens__NP_004723

<400>  5716

Met Gln Val Ser Ile Ala Cys Thr Glu Gln Asn Leu Arg Ser Arg Ser 
1               5                   10                  15      


Ser Glu Asp Arg Leu Cys Gly Pro Arg Pro Gly Pro Gly Gly Gly Asn 
            20                  25                  30          


Gly Gly Pro Ala Gly Gly Gly His Gly Asn Pro Pro Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Pro Lys Ala Arg Ala Ala Leu Val Pro Arg Pro Pro Ala Pro 
    50                  55                  60                  


Ala Gly Ala Leu Arg Glu Ser Thr Gly Arg Gly Thr Gly Met Lys Tyr 
65                  70                  75                  80  


Arg Asn Leu Gly Lys Ser Gly Leu Arg Val Ser Cys Leu Gly Leu Gly 
                85                  90                  95      


Thr Trp Val Thr Phe Gly Ser Gln Ile Ser Asp Glu Thr Ala Glu Asp 
            100                 105                 110         


Val Leu Thr Val Ala Tyr Glu His Gly Val Asn Leu Phe Asp Thr Ala 
        115                 120                 125             


Glu Val Tyr Ala Ala Gly Lys Ala Glu Arg Thr Leu Gly Asn Ile Leu 
    130                 135                 140                 


Lys Ser Lys Gly Trp Arg Arg Ser Ser Tyr Val Ile Thr Thr Lys Ile 
145                 150                 155                 160 


Phe Trp Gly Gly Gln Ala Glu Thr Glu Arg Gly Leu Ser Arg Lys His 
                165                 170                 175     


Ile Ile Glu Gly Leu Arg Gly Ser Leu Glu Arg Leu Gln Leu Gly Tyr 
            180                 185                 190         


Val Asp Ile Val Phe Ala Asn Arg Ser Asp Pro Asn Cys Pro Met Glu 
        195                 200                 205             


Glu Ile Val Arg Ala Met Thr Tyr Val Ile Asn Gln Gly Leu Ala Leu 
    210                 215                 220                 


Tyr Trp Gly Thr Ser Arg Trp Gly Ala Ala Glu Ile Met Glu Ala Tyr 
225                 230                 235                 240 


Ser Met Ala Arg Gln Phe Asn Leu Ile Pro Pro Val Cys Glu Gln Ala 
                245                 250                 255     


Glu His His Leu Phe Gln Arg Glu Lys Val Glu Met Gln Leu Pro Glu 
            260                 265                 270         


Leu Tyr His Lys Ile Gly Val Gly Ser Val Thr Trp Tyr Pro Leu Ala 
        275                 280                 285             


Cys Gly Leu Ile Thr Ser Lys Tyr Asp Gly Arg Val Pro Asp Thr Cys 
    290                 295                 300                 


Arg Ala Ser Ile Lys Gly Tyr Gln Trp Leu Lys Asp Lys Val Gln Ser 
305                 310                 315                 320 


Glu Asp Gly Lys Lys Gln Gln Ala Lys Val Met Asp Leu Leu Pro Val 
                325                 330                 335     


Ala His Gln Leu Gly Cys Thr Val Ala Gln Leu Ala Ile Ala Trp Cys 
            340                 345                 350         


Leu Arg Ser Glu Gly Val Ser Ser Val Leu Leu Gly Val Ser Ser Ala 
        355                 360                 365             


Glu Gln Leu Ile Glu His Leu Gly Ala Leu Gln Val Leu Ser Gln Leu 
    370                 375                 380                 


Thr Pro Gln Thr Val Met Glu Ile Asp Gly Leu Leu Gly Asn Lys Pro 
385                 390                 395                 400 


His Ser Lys Lys 
                


<210>  5717
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNB1__Homo_sapiens__XP_011527101

<400>  5717

Met Pro Ala Gly Met Thr Lys His Gly Ser Arg Ser Thr Ser Ser Leu 
1               5                   10                  15      


Pro Pro Glu Pro Met Glu Ile Val Arg Ser Lys Ala Cys Ser Arg Arg 
            20                  25                  30          


Val Arg Leu Asn Val Gly Gly Leu Ala His Glu Val Leu Trp Arg Thr 
        35                  40                  45              


Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu Arg Asp Cys Asn 
    50                  55                  60                  


Thr His Asp Ser Leu Leu Glu Val Cys Asp Asp Tyr Ser Leu Asp Asp 
65                  70                  75                  80  


Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe Thr Ser Ile Leu 
                85                  90                  95      


Asn Phe Tyr Arg Thr Gly Arg Leu His Met Met Glu Glu Met Cys Ala 
            100                 105                 110         


Leu Ser Phe Ser Gln Glu Leu Asp Tyr Trp Gly Ile Asp Glu Ile Tyr 
        115                 120                 125             


Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys Lys Glu Gln Met 
    130                 135                 140                 


Asn Glu Glu Leu Lys Arg Glu Ala Glu Thr Leu Arg Glu Arg Glu Gly 
145                 150                 155                 160 


Glu Glu Phe Asp Asn Thr Cys Cys Ala Glu Lys Arg Lys Lys Leu Trp 
                165                 170                 175     


Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala Lys Ile Leu Ala 
            180                 185                 190         


Ile Ile Ser Ile Met Phe Ile Val Leu Ser Thr Ile Ala Leu Ser Leu 
        195                 200                 205             


Asn Thr Leu Pro Glu Leu Gln Ser Leu Asp Glu Phe Gly Gln Ser Thr 
    210                 215                 220                 


Asp Asn Pro Gln Leu Ala His Val Glu Ala Val Cys Ile Ala Trp Phe 
225                 230                 235                 240 


Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro Lys Lys Trp Lys 
                245                 250                 255     


Phe Phe Lys Gly Pro Leu Asn Ala Ile Asp Leu Leu Ala Ile Leu Pro 
            260                 265                 270         


Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys Ser Val Leu Gln 
        275                 280                 285             


Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg Ile Met Arg Ile 
    290                 295                 300                 


Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser Leu 
305                 310                 315                 320 


Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly Leu Leu Ile Leu 
                325                 330                 335     


Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu Val Phe Phe Ala 
            340                 345                 350         


Glu Lys Asp Glu Asp Asp Thr Lys Phe Lys Ser Ile Pro Ala Ser Phe 
        355                 360                 365             


Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr Gly Asp Ile Tyr 
    370                 375                 380                 


Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu Cys Cys Ile Ala 
385                 390                 395                 400 


Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile Val Asn Asn Phe 
                405                 410                 415     


Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys Ala Ile Lys Arg 
            420                 425                 430         


Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser Ile Val Ser Met 
        435                 440                 445             


Asn Met Lys Asp Ala Phe Ala Arg Ser Ile Glu Met Met Asp Ile Val 
    450                 455                 460                 


Val Glu Lys Asn Gly Glu Asn Met Gly Lys Lys Asp Lys Val Gln Asp 
465                 470                 475                 480 


Asn His Leu Ser Pro Asn Lys Trp Lys Trp Thr Lys Arg Thr Leu Ser 
                485                 490                 495     


Glu Thr Ser Ser Ser Lys Ser Phe Glu Thr Lys Glu Gln Gly Ser Pro 
            500                 505                 510         


Glu Lys Ala Arg Ser Ser Ser Ser Pro Gln His Leu Asn Val Gln Gln 
        515                 520                 525             


Leu Glu Asp Met Tyr Asn Lys Met Ala Lys Thr Gln Ser Gln Pro Ile 
    530                 535                 540                 


Leu Asn Thr Lys Glu Ser Ala Ala Gln Ser Lys Pro Lys Glu Glu Leu 
545                 550                 555                 560 


Glu Met Glu Ser Ile Pro Ser Pro Val Ala Pro Leu Pro Thr Arg Thr 
                565                 570                 575     


Glu Gly Val Ile Asp Met Arg Ser Met Ser Ser Ile Asp Ser Phe Ile 
            580                 585                 590         


Ser Cys Ala Thr Asp Phe Pro Glu Ala Thr Arg Phe Ser His Ser Pro 
        595                 600                 605             


Leu Thr Ser Leu Pro Ser Lys Thr Gly Gly Ser Thr Ala Pro Glu Val 
    610                 615                 620                 


Gly Trp Arg Gly Ala Leu Gly Ala Ser Gly Gly Arg Phe Val Glu Ala 
625                 630                 635                 640 


Asn Pro Ser Pro Asp Ala Ser Gln His Ser Ser Phe Phe Ile Glu Ser 
                645                 650                 655     


Pro Lys Ser Ser Met Lys Thr Asn Asn Pro Leu Lys Leu Arg Ala Leu 
            660                 665                 670         


Lys Val Asn Phe Met Glu Gly Asp Pro Ser Pro Leu Leu Pro Val Leu 
        675                 680                 685             


Gly Met Tyr His Asp Pro Leu Arg Asn Arg Gly Ser Ala Ala Ala Ala 
    690                 695                 700                 


Val Ala Gly Leu Glu Cys Ala Thr Leu Leu Asp Lys Ala Val Leu Ser 
705                 710                 715                 720 


Pro Glu Ser Ser Ile Tyr Thr Thr Ala Ser Ala Lys Thr Pro Pro Arg 
                725                 730                 735     


Ser Pro Glu Lys His Thr Ala Ile Ala Phe Asn Phe Glu Ala Gly Val 
            740                 745                 750         


His Gln Tyr Ile Asp Ala Asp Thr Asp Asp Glu Gly Gln Leu Leu Tyr 
        755                 760                 765             


Ser Val Asp Ser Ser Pro Pro Lys Ser Leu Pro Gly Ser Thr Ser Pro 
    770                 775                 780                 


Lys Phe Ser Thr Gly Thr Arg Ser Glu Lys Asn His Phe Glu Ser Ser 
785                 790                 795                 800 


Pro Leu Pro Thr Ser Pro Lys Phe Leu Arg Gln Asn Cys Ile Tyr Ser 
                805                 810                 815     


Thr Glu Ala Leu Thr Gly Lys Gly Pro Ser Gly Gln Glu Lys Cys Lys 
            820                 825                 830         


Leu Glu Asn His Ile Ser Pro Asp Val Arg Val Leu Pro Gly Gly Gly 
        835                 840                 845             


Ala His Gly Ser Thr Arg Asp Gln Ser Ile 
    850                 855             


<210>  5718
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNB2__Homo_sapiens__NP_004761

<400>  5718

Met Ala Glu Lys Ala Pro Pro Gly Leu Asn Arg Lys Thr Ser Arg Ser 
1               5                   10                  15      


Thr Leu Ser Leu Pro Pro Glu Pro Val Asp Ile Ile Arg Ser Lys Thr 
            20                  25                  30          


Cys Ser Arg Arg Val Lys Ile Asn Val Gly Gly Leu Asn His Glu Val 
        35                  40                  45              


Leu Trp Arg Thr Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu 
    50                  55                  60                  


Arg Asp Cys Asn Thr His Glu Ser Leu Leu Glu Val Cys Asp Asp Tyr 
65                  70                  75                  80  


Asn Leu Asn Glu Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe 
                85                  90                  95      


Thr Ser Ile Leu Asn Phe Tyr Arg Thr Gly Lys Leu His Met Met Glu 
            100                 105                 110         


Glu Met Cys Ala Leu Ser Phe Gly Gln Glu Leu Asp Tyr Trp Gly Ile 
        115                 120                 125             


Asp Glu Ile Tyr Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys 
    130                 135                 140                 


Lys Glu Gln Met Asn Glu Glu Leu Arg Arg Glu Ala Glu Thr Met Arg 
145                 150                 155                 160 


Glu Arg Glu Gly Glu Glu Phe Asp Asn Thr Cys Cys Pro Asp Lys Arg 
                165                 170                 175     


Lys Lys Leu Trp Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala 
            180                 185                 190         


Lys Ile Leu Ala Ile Val Ser Ile Leu Phe Ile Val Leu Ser Thr Ile 
        195                 200                 205             


Ala Leu Ser Leu Asn Thr Leu Pro Glu Leu Gln Glu Thr Asp Glu Phe 
    210                 215                 220                 


Gly Gln Leu Asn Asp Asn Arg Gln Leu Ala His Val Glu Ala Val Cys 
225                 230                 235                 240 


Ile Ala Trp Phe Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro 
                245                 250                 255     


Asn Lys Trp Lys Phe Phe Lys Gly Pro Leu Asn Val Ile Asp Leu Leu 
            260                 265                 270         


Ala Ile Leu Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys 
        275                 280                 285             


Ser Val Leu Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg 
    290                 295                 300                 


Ile Met Arg Ile Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly 
305                 310                 315                 320 


Leu Gln Ser Leu Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly 
                325                 330                 335     


Leu Leu Ile Leu Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu 
            340                 345                 350         


Val Phe Phe Ala Glu Lys Asp Glu Asp Ala Thr Lys Phe Thr Ser Ile 
        355                 360                 365             


Pro Ala Ser Phe Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr 
    370                 375                 380                 


Gly Asp Ile Tyr Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu 
385                 390                 395                 400 


Cys Cys Ile Ala Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile 
                405                 410                 415     


Val Asn Asn Phe Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys 
            420                 425                 430         


Ala Ile Lys Arg Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser 
        435                 440                 445             


Ile Val Ser Met Asn Leu Lys Asp Ala Phe Ala Arg Ser Met Glu Leu 
    450                 455                 460                 


Ile Asp Val Ala Val Glu Lys Ala Gly Glu Ser Ala Asn Thr Lys Asp 
465                 470                 475                 480 


Ser Ala Asp Asp Asn His Leu Ser Pro Ser Arg Trp Lys Trp Ala Arg 
                485                 490                 495     


Lys Ala Leu Ser Glu Thr Ser Ser Asn Lys Ser Phe Glu Asn Lys Tyr 
            500                 505                 510         


Gln Glu Val Ser Gln Lys Asp Ser His Glu Gln Leu Asn Asn Thr Ser 
        515                 520                 525             


Ser Ser Ser Pro Gln His Leu Ser Ala Gln Lys Leu Glu Met Leu Tyr 
    530                 535                 540                 


Asn Glu Ile Thr Lys Thr Gln Pro His Ser His Pro Asn Pro Asp Cys 
545                 550                 555                 560 


Gln Glu Lys Pro Glu Arg Pro Ser Ala Tyr Glu Glu Glu Ile Glu Met 
                565                 570                 575     


Glu Glu Val Val Cys Pro Gln Glu Gln Leu Ala Val Ala Gln Thr Glu 
            580                 585                 590         


Val Ile Val Asp Met Lys Ser Thr Ser Ser Ile Asp Ser Phe Thr Ser 
        595                 600                 605             


Cys Ala Thr Asp Phe Thr Glu Thr Glu Arg Ser Pro Leu Pro Pro Pro 
    610                 615                 620                 


Ser Ala Ser His Leu Gln Met Lys Phe Pro Thr Asp Leu Pro Gly Thr 
625                 630                 635                 640 


Glu Glu His Gln Arg Ala Arg Gly Pro Pro Phe Leu Thr Leu Ser Arg 
                645                 650                 655     


Glu Lys Gly Pro Ala Ala Arg Asp Gly Thr Leu Glu Tyr Ala Pro Val 
            660                 665                 670         


Asp Ile Thr Val Asn Leu Asp Ala Ser Gly Ser Gln Cys Gly Leu His 
        675                 680                 685             


Ser Pro Leu Gln Ser Asp Asn Ala Thr Asp Ser Pro Lys Ser Ser Leu 
    690                 695                 700                 


Lys Gly Ser Asn Pro Leu Lys Ser Arg Ser Leu Lys Val Asn Phe Lys 
705                 710                 715                 720 


Glu Asn Arg Gly Ser Ala Pro Gln Thr Pro Pro Ser Thr Ala Arg Pro 
                725                 730                 735     


Leu Pro Val Thr Thr Ala Asp Phe Ser Leu Thr Thr Pro Gln His Ile 
            740                 745                 750         


Ser Thr Ile Leu Leu Glu Glu Thr Pro Ser Gln Gly Asp Arg Pro Leu 
        755                 760                 765             


Leu Gly Thr Glu Val Ser Ala Pro Cys Gln Gly Pro Ser Lys Gly Leu 
    770                 775                 780                 


Ser Pro Arg Phe Pro Lys Gln Lys Leu Phe Pro Phe Ser Ser Arg Glu 
785                 790                 795                 800 


Arg Arg Ser Phe Thr Glu Ile Asp Thr Gly Asp Asp Glu Asp Phe Leu 
                805                 810                 815     


Glu Leu Pro Gly Ala Arg Glu Glu Lys Gln Val Asp Ser Ser Pro Asn 
            820                 825                 830         


Cys Phe Ala Asp Lys Pro Ser Asp Gly Arg Asp Pro Leu Arg Glu Glu 
        835                 840                 845             


Gly Ser Val Gly Ser Ser Ser Pro Gln Asp Thr Gly His Asn Cys Arg 
    850                 855                 860                 


Gln Asp Ile Tyr His Ala Val Ser Glu Val Lys Lys Asp Ser Ser Gln 
865                 870                 875                 880 


Glu Gly Cys Lys Met Glu Asn His Leu Phe Ala Pro Glu Ile His Ser 
                885                 890                 895     


Asn Pro Gly Asp Thr Gly Tyr Cys Pro Thr Arg Glu Thr Ser Met 
            900                 905                 910     


<210>  5719
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNC1__Homo_sapiens__NP_001106212

<400>  5719

Met Gly Gln Gly Asp Glu Ser Glu Arg Ile Val Ile Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Gln Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Trp Leu Ala Glu Pro Asp Ala His Ser His Phe Asp Tyr 
        35                  40                  45              


Asp Pro Arg Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
    50                  55                  60                  


Ala His Ile Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
65                  70                  75                  80  


Asp Val Cys Gly Pro Leu Tyr Glu Glu Glu Leu Ala Phe Trp Gly Ile 
                85                  90                  95      


Asp Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His 
            100                 105                 110         


Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Gly Gly Ala Pro Leu Asp 
        115                 120                 125             


Asn Ser Ala Asp Asp Ala Asp Ala Asp Gly Pro Gly Asp Ser Gly Asp 
    130                 135                 140                 


Gly Glu Asp Glu Leu Glu Met Thr Lys Arg Leu Ala Leu Ser Asp Ser 
145                 150                 155                 160 


Pro Asp Gly Arg Pro Gly Gly Phe Trp Arg Arg Trp Gln Pro Arg Ile 
                165                 170                 175     


Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Tyr Ala Arg Tyr Val 
            180                 185                 190         


Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile Thr Thr Phe Cys 
        195                 200                 205             


Leu Glu Thr His Glu Arg Phe Asn Pro Ile Val Asn Lys Thr Glu Ile 
    210                 215                 220                 


Glu Asn Val Arg Asn Gly Thr Gln Val Arg Tyr Tyr Arg Glu Ala Glu 
225                 230                 235                 240 


Thr Glu Ala Phe Leu Thr Tyr Ile Glu Gly Val Cys Val Val Trp Phe 
                245                 250                 255     


Thr Phe Glu Phe Leu Met Arg Val Ile Phe Cys Pro Asn Lys Val Glu 
            260                 265                 270         


Phe Ile Lys Asn Ser Leu Asn Ile Ile Asp Phe Val Ala Ile Leu Pro 
        275                 280                 285             


Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys Ala Ala Lys 
    290                 295                 300                 


Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg Ile Leu Arg 
305                 310                 315                 320 


Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg Val Leu Gly His 
                325                 330                 335     


Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu Ile Ile Phe Leu 
            340                 345                 350         


Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr Tyr Ala Glu Arg 
        355                 360                 365             


Ile Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser Glu His Thr His Phe 
    370                 375                 380                 


Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val Thr Met Thr Thr 
385                 390                 395                 400 


Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp Ser Gly Met Leu Val 
                405                 410                 415     


Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile Ala Met Pro Val 
            420                 425                 430         


Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser Leu Ala Met Ala 
        435                 440                 445             


Lys Gln Lys Leu Pro Lys Lys Lys Lys Lys His Ile Pro Arg Pro Pro 
    450                 455                 460                 


Gln Leu Gly Ser Pro Asn Tyr Cys Lys Ser Val Val Asn Ser Pro His 
465                 470                 475                 480 


His Ser Thr Gln Ser Asp Thr Cys Pro Leu Ala Gln Glu Glu Ile Leu 
                485                 490                 495     


Glu Ile Asn Arg Ala Asp Ser Lys Leu Asn Gly Glu Val Ala Lys Ala 
            500                 505                 510         


Ala Leu Ala Asn Glu Asp Cys Pro His Ile Asp Gln Ala Leu Thr Pro 
        515                 520                 525             


Asp Glu Gly Leu Pro Phe Thr Arg Ser Gly Thr Arg Glu Arg Tyr Gly 
    530                 535                 540                 


Pro Cys Phe Leu Leu Ser Thr Gly Glu Tyr Ala Cys Pro Pro Gly Gly 
545                 550                 555                 560 


Gly Met Arg Lys Asp Leu Cys Lys Glu Ser Pro Val Ile Ala Lys Tyr 
                565                 570                 575     


Met Pro Thr Glu Ala Val Arg Val Thr 
            580                 585 


<210>  5720
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNC2__Homo_sapiens__NP_001247427

<400>  5720

Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Pro Gly Asp Cys Leu Thr 
        35                  40                  45              


Thr Ala Gly Asp Lys Leu Gln Pro Ser Pro Pro Pro Leu Ser Pro Pro 
    50                  55                  60                  


Pro Arg Ala Pro Pro Leu Ser Pro Gly Pro Gly Gly Cys Phe Glu Gly 
65                  70                  75                  80  


Gly Ala Gly Asn Cys Ser Ser Arg Gly Gly Arg Ala Ser Asp His Pro 
                85                  90                  95      


Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala 
            100                 105                 110         


Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp 
        115                 120                 125             


Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp 
    130                 135                 140                 


Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly 
                165                 170                 175     


Gly Asp Pro Gly Asp Asp Glu Asp Leu Ala Ala Lys Arg Leu Gly Ile 
            180                 185                 190         


Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp 
        195                 200                 205             


Arg Arg Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser 
    210                 215                 220                 


Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu 
225                 230                 235                 240 


Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile 
                245                 250                 255     


Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Val Val Leu 
            260                 265                 270         


Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val 
        275                 280                 285             


Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser 
    290                 295                 300                 


Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe 
305                 310                 315                 320 


Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                325                 330                 335     


Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
            340                 345                 350         


Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
        355                 360                 365             


Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
    370                 375                 380                 


Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
385                 390                 395                 400 


Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser 
                405                 410                 415     


Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
            420                 425                 430         


Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp 
        435                 440                 445             


Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
    450                 455                 460                 


Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
465                 470                 475                 480 


Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His 
                485                 490                 495     


Ile Pro Pro Ala Pro Gln Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu 
            500                 505                 510         


Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys 
        515                 520                 525             


Asp Asn Arg Leu Leu Glu His Asn Arg Ser Val Leu Ser Gly Asp Asp 
    530                 535                 540                 


Ser Thr Gly Ser Glu Pro Pro Leu Ser Pro Pro Glu Arg Leu Pro Ile 
545                 550                 555                 560 


Arg Arg Ser Ser Thr Arg Asp Lys Asn Arg Arg Gly Glu Thr Cys Phe 
                565                 570                 575     


Leu Leu Thr Thr Gly Asp Tyr Thr Cys Ala Ser Asp Gly Gly Ile Arg 
            580                 585                 590         


Lys Val Leu Tyr Arg Ile Tyr His Gly Leu Leu Thr Ala Glu Lys Gly 
        595                 600                 605             


Thr Val Glu Phe Ser His Thr Lys Asp Tyr Thr Gly Asn Arg Leu Leu 
    610                 615                 620                 


Leu Leu Asn Val Pro 
625                 


<210>  5721
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNC3__Homo_sapiens__XP_006723266

<400>  5721

Met Leu Ser Ser Val Cys Val Ser Ser Phe Arg Gly Arg Gln Gly Ala 
1               5                   10                  15      


Ser Lys Gln Gln Pro Ala Pro Pro Pro Gln Pro Pro Glu Ser Pro Pro 
            20                  25                  30          


Pro Pro Pro Leu Pro Pro Gln Gln Gln Gln Pro Ala Gln Pro Gly Pro 
        35                  40                  45              


Ala Ala Ser Pro Ala Gly Pro Pro Ala Pro Arg Gly Pro Gly Asp Arg 
    50                  55                  60                  


Arg Ala Glu Pro Cys Pro Gly Leu Pro Ala Ala Ala Met Gly Arg His 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Asp Ser Gly Lys Ile Val Ile Asn Val Gly Gly 
                85                  90                  95      


Val Arg His Glu Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
            100                 105                 110         


Arg Leu Ala Gly Leu Thr Glu Pro Glu Ala Ala Ala Arg Phe Asp Tyr 
        115                 120                 125             


Asp Pro Gly Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
    130                 135                 140                 


Ala Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
145                 150                 155                 160 


Asp Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Gly Phe Trp Gly Ile 
                165                 170                 175     


Asp Glu Thr Asp Val Glu Ala Cys Cys Trp Met Thr Tyr Arg Gln His 
            180                 185                 190         


Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Glu Ala Pro Asp Pro Ala 
        195                 200                 205             


Gly Ala Ala Asn Ala Ala Asn Ala Ala Gly Ala His Asp Gly Gly Leu 
    210                 215                 220                 


Asp Asp Glu Ala Gly Ala Gly Gly Gly Gly Leu Asp Gly Ala Gly Gly 
225                 230                 235                 240 


Glu Leu Lys Arg Leu Cys Phe Gln Asp Ala Gly Gly Gly Ala Gly Gly 
                245                 250                 255     


Pro Pro Gly Gly Ala Gly Gly Ala Gly Gly Thr Trp Trp Arg Arg Trp 
            260                 265                 270         


Gln Pro Arg Val Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
        275                 280                 285             


Ala Arg Tyr Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Ile Ser Ile 
    290                 295                 300                 


Thr Thr Phe Cys Leu Glu Thr His Glu Gly Phe Ile His Ile Ser Asn 
305                 310                 315                 320 


Lys Thr Val Thr Gln Ala Ser Pro Ile Pro Gly Ala Pro Pro Glu Asn 
                325                 330                 335     


Ile Thr Asn Val Glu Val Glu Thr Glu Pro Phe Leu Thr Tyr Val Glu 
            340                 345                 350         


Gly Val Cys Val Val Trp Phe Thr Phe Glu Phe Leu Met Arg Ile Thr 
        355                 360                 365             


Phe Cys Pro Asp Lys Val Glu Phe Leu Lys Ser Ser Leu Asn Ile Ile 
    370                 375                 380                 


Asp Cys Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly 
385                 390                 395                 400 


Leu Ser Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val 
                405                 410                 415     


Arg Phe Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val 
            420                 425                 430         


Gly Leu Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe 
        435                 440                 445             


Leu Leu Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr 
    450                 455                 460                 


Met Ile Tyr Tyr Ala Glu Arg Ile Gly Ala Asp Pro Asp Asp Ile Leu 
465                 470                 475                 480 


Gly Ser Asn His Thr Tyr Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp 
                485                 490                 495     


Ala Val Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys 
            500                 505                 510         


Thr Trp Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val 
        515                 520                 525             


Leu Thr Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met 
    530                 535                 540                 


Tyr Tyr Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Lys Asn 
545                 550                 555                 560 


Lys His Ile Pro Arg Pro Pro Gln Pro Gly Ser Pro Asn Tyr Cys Lys 
                565                 570                 575     


Pro Asp Pro Pro Pro Pro Pro Pro Pro His Pro His His Gly Ser Gly 
            580                 585                 590         


Gly Ile Ser Pro Pro Pro Pro Ile Thr Pro Pro Ser Met Gly Val Thr 
        595                 600                 605             


Val Ala Gly Ala Tyr Pro Ala Gly Pro His Thr His Pro Gly Leu Leu 
    610                 615                 620                 


Arg Gly Gly Ala Gly Gly Leu Gly Ile Met Gly Leu Pro Pro Leu Pro 
625                 630                 635                 640 


Ala Pro Gly Glu Pro Cys Pro Leu Ala Gln Glu Glu Val Ile Glu Ile 
                645                 650                 655     


Asn Arg Ala Asp Pro Arg Pro Asn Gly Asp Pro Ala Ala Ala Ala Leu 
            660                 665                 670         


Ala His Glu Asp Cys Pro Ala Ile Asp Gln Pro Ala Met Ser Pro Glu 
        675                 680                 685             


Asp Lys Ser Pro Ile Thr Pro Gly Ser Arg Gly Arg Tyr Ser Arg Asp 
    690                 695                 700                 


Arg Ala Cys Phe Leu Leu Thr Asp Tyr Ala Pro Ser Pro Asp Gly Ser 
705                 710                 715                 720 


Ile Arg Lys Ala Thr Gly Ala Pro Pro Leu Pro Pro Gln Asp Trp Arg 
                725                 730                 735     


Lys Pro Gly Pro Pro Ser Phe Leu Pro Asp Leu Asn Ala Asn Ala Ala 
            740                 745                 750         


Ala Trp Ile Ser Pro 
        755         


<210>  5722
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCND2__Homo_sapiens__NP_036413

<400>  5722

Met Ala Ala Gly Val Ala Ala Trp Leu Pro Phe Ala Arg Ala Ala Ala 
1               5                   10                  15      


Ile Gly Trp Met Pro Val Ala Ser Gly Pro Met Pro Ala Pro Pro Arg 
            20                  25                  30          


Gln Glu Arg Lys Arg Thr Gln Asp Ala Leu Ile Val Leu Asn Val Ser 
        35                  40                  45              


Gly Thr Arg Phe Gln Thr Trp Gln Asp Thr Leu Glu Arg Tyr Pro Asp 
    50                  55                  60                  


Thr Leu Leu Gly Ser Ser Glu Arg Asp Phe Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Gln Gln Tyr Phe Phe Asp Arg Asp Pro Asp Ile Phe Arg His Ile Leu 
                85                  90                  95      


Asn Phe Tyr Arg Thr Gly Lys Leu His Tyr Pro Arg His Glu Cys Ile 
            100                 105                 110         


Ser Ala Tyr Asp Glu Glu Leu Ala Phe Phe Gly Leu Ile Pro Glu Ile 
        115                 120                 125             


Ile Gly Asp Cys Cys Tyr Glu Glu Tyr Lys Asp Arg Arg Arg Glu Asn 
    130                 135                 140                 


Ala Glu Arg Leu Gln Asp Asp Ala Asp Thr Asp Thr Ala Gly Glu Ser 
145                 150                 155                 160 


Ala Leu Pro Thr Met Thr Ala Arg Gln Arg Val Trp Arg Ala Phe Glu 
                165                 170                 175     


Asn Pro His Thr Ser Thr Met Ala Leu Val Phe Tyr Tyr Val Thr Gly 
            180                 185                 190         


Phe Phe Ile Ala Val Ser Val Ile Ala Asn Val Val Glu Thr Val Pro 
        195                 200                 205             


Cys Gly Ser Ser Pro Gly His Ile Lys Glu Leu Pro Cys Gly Glu Arg 
    210                 215                 220                 


Tyr Ala Val Ala Phe Phe Cys Leu Asp Thr Ala Cys Val Met Ile Phe 
225                 230                 235                 240 


Thr Val Glu Tyr Leu Leu Arg Leu Ala Ala Ala Pro Ser Arg Tyr Arg 
                245                 250                 255     


Phe Val Arg Ser Val Met Ser Ile Ile Asp Val Val Ala Ile Leu Pro 
            260                 265                 270         


Tyr Tyr Ile Gly Leu Val Met Thr Asp Asn Glu Asp Val Ser Gly Ala 
        275                 280                 285             


Phe Val Thr Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys Phe Ser 
    290                 295                 300                 


Arg His Ser Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys Ser Cys 
305                 310                 315                 320 


Ala Ser Glu Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala Ile Ile 
                325                 330                 335     


Ile Phe Ala Thr Val Met Phe Tyr Ala Glu Lys Gly Ser Ser Ala Ser 
            340                 345                 350         


Lys Phe Thr Ser Ile Pro Ala Ala Phe Trp Tyr Thr Ile Val Thr Met 
        355                 360                 365             


Thr Thr Leu Gly Tyr Gly Asp Met Val Pro Lys Thr Ile Ala Gly Lys 
    370                 375                 380                 


Ile Phe Gly Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile Ala Leu 
385                 390                 395                 400 


Pro Val Pro Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His Gln Asn 
                405                 410                 415     


Gln Arg Ala Asp Lys Arg Arg Ala Gln Lys Lys Ala Arg Leu Ala Arg 
            420                 425                 430         


Ile Arg Ala Ala Lys Ser Gly Ser Ala Asn Ala Tyr Met Gln Ser Lys 
        435                 440                 445             


Arg Asn Gly Leu Leu Ser Asn Gln Leu Gln Ser Ser Glu Asp Glu Gln 
    450                 455                 460                 


Ala Phe Val Ser Lys Ser Gly Ser Ser Phe Glu Thr Gln His His His 
465                 470                 475                 480 


Leu Leu His Cys Leu Glu Lys Thr Thr Asn His Glu Phe Val Asp Glu 
                485                 490                 495     


Gln Val Phe Glu Glu Ser Cys Met Glu Val Ala Thr Val Asn Arg Pro 
            500                 505                 510         


Ser Ser His Ser Pro Ser Leu Ser Ser Gln Gln Gly Val Thr Ser Thr 
        515                 520                 525             


Cys Cys Ser Arg Arg His Lys Lys Thr Phe Arg Ile Pro Asn Ala Asn 
    530                 535                 540                 


Val Ser Gly Ser His Gln Gly Ser Ile Gln Glu Leu Ser Thr Ile Gln 
545                 550                 555                 560 


Ile Arg Cys Val Glu Arg Thr Pro Leu Ser Asn Ser Arg Ser Ser Leu 
                565                 570                 575     


Asn Ala Lys Met Glu Glu Cys Val Lys Leu Asn Cys Glu Gln Pro Tyr 
            580                 585                 590         


Val Thr Thr Ala Ile Ile Ser Ile Pro Thr Pro Pro Val Thr Thr Pro 
        595                 600                 605             


Glu Gly Asp Asp Arg Pro Glu Ser Pro Glu Tyr Ser Gly Gly Asn Ile 
    610                 615                 620                 


Val Arg Val Ser Ala Leu 
625                 630 


<210>  5723
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNE1__Homo_sapiens__NP_001257334

<400>  5723

Met Ile Leu Ser Asn Thr Thr Ala Val Thr Pro Phe Leu Thr Lys Leu 
1               5                   10                  15      


Trp Gln Glu Thr Val Gln Gln Gly Gly Asn Met Ser Gly Leu Ala Arg 
            20                  25                  30          


Arg Ser Pro Arg Ser Ser Asp Gly Lys Leu Glu Ala Leu Tyr Val Leu 
        35                  40                  45              


Met Val Leu Gly Phe Phe Gly Phe Phe Thr Leu Gly Ile Met Leu Ser 
    50                  55                  60                  


Tyr Ile Arg Ser Lys Lys Leu Glu His Ser Asn Asp Pro Phe Asn Val 
65                  70                  75                  80  


Tyr Ile Glu Ser Asp Ala Trp Gln Glu Lys Asp Lys Ala Tyr Val Gln 
                85                  90                  95      


Ala Arg Val Leu Glu Ser Tyr Arg Ser Cys Tyr Val Val Glu Asn His 
            100                 105                 110         


Leu Ala Ile Glu Gln Pro Asn Thr His Leu Pro Glu Thr Lys Pro Ser 
        115                 120                 125             


Pro 
    


<210>  5724
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNE2__Homo_sapiens__NP_751951

<400>  5724

Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg 
1               5                   10                  15      


Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala 
            20                  25                  30          


Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr 
        35                  40                  45              


Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile 
    50                  55                  60                  


Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser 
65                  70                  75                  80  


Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr 
                85                  90                  95      


Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu 
            100                 105                 110         


Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro 
        115                 120             


<210>  5725
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNE3__Homo_sapiens__NP_005463

<400>  5725

Met Glu Thr Thr Asn Gly Thr Glu Thr Trp Tyr Glu Ser Leu His Ala 
1               5                   10                  15      


Val Leu Lys Ala Leu Asn Ala Thr Leu His Ser Asn Leu Leu Cys Arg 
            20                  25                  30          


Pro Gly Pro Gly Leu Gly Pro Asp Asn Gln Thr Glu Glu Arg Arg Ala 
        35                  40                  45              


Ser Leu Pro Gly Arg Asp Asp Asn Ser Tyr Met Tyr Ile Leu Phe Val 
    50                  55                  60                  


Met Phe Leu Phe Ala Val Thr Val Gly Ser Leu Ile Leu Gly Tyr Thr 
65                  70                  75                  80  


Arg Ser Arg Lys Val Asp Lys Arg Ser Asp Pro Tyr His Val Tyr Ile 
                85                  90                  95      


Lys Asn Arg Val Ser Met Ile 
            100             


<210>  5726
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNE4__Homo_sapiens__NP_542402

<400>  5726

Met His Phe Leu Thr Ile Tyr Pro Asn Cys Ser Ser Gly Val Val Arg 
1               5                   10                  15      


Ala Gln Ser Arg Thr Glu Gln Lys Asn Pro Leu Gly Leu Asp Asp Leu 
            20                  25                  30          


Gly Ile Gln Asn Leu Gly Gln Thr Val Ser Leu Ala Pro Ala Val Glu 
        35                  40                  45              


Ala Ala Ser Met Leu Lys Met Glu Pro Leu Asn Ser Thr His Pro Gly 
    50                  55                  60                  


Thr Ala Ala Ser Ser Ser Pro Leu Glu Ser Arg Ala Ala Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Asn Gly Asn Glu Tyr Phe Tyr Ile Leu Val Val Met Ser Phe 
                85                  90                  95      


Tyr Gly Ile Phe Leu Ile Gly Ile Met Leu Gly Tyr Met Lys Ser Lys 
            100                 105                 110         


Arg Arg Glu Lys Lys Ser Ser Leu Leu Leu Leu Tyr Lys Asp Glu Glu 
        115                 120                 125             


Arg Leu Trp Gly Glu Ala Met Lys Pro Leu Pro Val Val Ser Gly Leu 
    130                 135                 140                 


Arg Ser Val Gln Val Pro Leu Met Leu Asn Met Leu Gln Glu Ser Val 
145                 150                 155                 160 


Ala Pro Ala Leu Ser Cys Thr Leu Cys Ser Met Glu Gly Asp Ser Val 
                165                 170                 175     


Ser Ser Glu Ser Ser Ser Pro Asp Val His Leu Thr Ile Gln Glu Glu 
            180                 185                 190         


Gly Ala Asp Asp Glu Leu Glu Glu Thr Ser Glu Thr Pro Leu Asn Glu 
        195                 200                 205             


Ser Ser Glu Gly Ser Ser Glu Asn Ile His Gln Asn Ser 
    210                 215                 220     


<210>  5727
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNE5__Homo_sapiens__NP_036414

<400>  5727

Met Asn Cys Ser Glu Ser Gln Arg Leu Arg Thr Leu Leu Ser Arg Leu 
1               5                   10                  15      


Leu Leu Glu Leu His His Arg Gly Asn Ala Ser Gly Leu Gly Ala Gly 
            20                  25                  30          


Pro Arg Pro Ser Met Gly Met Gly Val Val Pro Asp Pro Phe Val Gly 
        35                  40                  45              


Arg Glu Val Thr Ser Ala Lys Gly Asp Asp Ala Tyr Leu Tyr Ile Leu 
    50                  55                  60                  


Leu Ile Met Ile Phe Tyr Ala Cys Leu Ala Gly Gly Leu Ile Leu Ala 
65                  70                  75                  80  


Tyr Thr Arg Ser Arg Lys Leu Val Glu Ala Lys Asp Glu Pro Ser Gln 
                85                  90                  95      


Ala Cys Ala Glu His Glu Trp Ala Pro Gly Gly Ala Leu Thr Ala Asp 
            100                 105                 110         


Ala Glu Ala Ala Ala Gly Ser Gln Ala Glu Gly Arg Arg Gln Leu Ala 
        115                 120                 125             


Ser Glu Gly Leu Pro Ala Leu Ala Gln Gly Ala Glu Arg Val 
    130                 135                 140         


<210>  5728
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNG3__Homo_sapiens__NP_579875

<400>  5728

Met Thr Phe Gly Arg Ser Gly Ala Ala Ser Val Val Leu Asn Val Gly 
1               5                   10                  15      


Gly Ala Arg Tyr Ser Leu Ser Arg Glu Leu Leu Lys Asp Phe Pro Leu 
            20                  25                  30          


Arg Arg Val Ser Arg Leu His Gly Cys Arg Ser Glu Arg Asp Val Leu 
        35                  40                  45              


Glu Val Cys Asp Asp Tyr Asp Arg Glu Arg Asn Glu Tyr Phe Phe Asp 
    50                  55                  60                  


Arg His Ser Glu Ala Phe Gly Phe Ile Leu Leu Tyr Val Arg Gly His 
65                  70                  75                  80  


Gly Lys Leu Arg Phe Ala Pro Arg Met Cys Glu Leu Ser Phe Tyr Asn 
                85                  90                  95      


Glu Met Ile Tyr Trp Gly Leu Glu Gly Ala His Leu Glu Tyr Cys Cys 
            100                 105                 110         


Gln Arg Arg Leu Asp Asp Arg Met Ser Asp Thr Tyr Thr Phe Tyr Ser 
        115                 120                 125             


Ala Asp Glu Pro Gly Val Leu Gly Arg Asp Glu Ala Arg Pro Gly Gly 
    130                 135                 140                 


Ala Glu Ala Ala Pro Ser Arg Arg Trp Leu Glu Arg Met Arg Arg Thr 
145                 150                 155                 160 


Phe Glu Glu Pro Thr Ser Ser Leu Ala Ala Gln Ile Leu Ala Ser Val 
                165                 170                 175     


Ser Val Val Phe Val Ile Val Ser Met Val Val Leu Cys Ala Ser Thr 
            180                 185                 190         


Leu Pro Asp Trp Arg Asn Ala Ala Ala Asp Asn Arg Ser Leu Asp Asp 
        195                 200                 205             


Arg Ser Arg Tyr Ser Ala Gly Pro Gly Arg Glu Pro Ser Gly Ile Ile 
    210                 215                 220                 


Glu Ala Ile Cys Ile Gly Trp Phe Thr Ala Glu Cys Ile Val Arg Phe 
225                 230                 235                 240 


Ile Val Ser Lys Asn Lys Cys Glu Phe Val Lys Arg Pro Leu Asn Ile 
                245                 250                 255     


Ile Asp Leu Leu Ala Ile Thr Pro Tyr Tyr Ile Ser Val Leu Met Thr 
            260                 265                 270         


Val Phe Thr Gly Glu Asn Ser Gln Leu Gln Arg Ala Gly Val Thr Leu 
        275                 280                 285             


Arg Val Leu Arg Met Met Arg Ile Phe Trp Val Ile Lys Leu Ala Arg 
    290                 295                 300                 


His Phe Ile Gly Leu Gln Thr Leu Gly Leu Thr Leu Lys Arg Cys Tyr 
305                 310                 315                 320 


Arg Glu Met Val Met Leu Leu Val Phe Ile Cys Val Ala Met Ala Ile 
                325                 330                 335     


Phe Ser Ala Leu Ser Gln Leu Leu Glu His Gly Leu Asp Leu Glu Thr 
            340                 345                 350         


Ser Asn Lys Asp Phe Thr Ser Ile Pro Ala Ala Cys Trp Trp Val Ile 
        355                 360                 365             


Ile Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Ile Thr Val 
    370                 375                 380                 


Pro Gly Arg Ile Leu Gly Gly Val Cys Val Val Ser Gly Ile Val Leu 
385                 390                 395                 400 


Leu Ala Leu Pro Ile Thr Phe Ile Tyr His Ser Phe Val Gln Cys Tyr 
                405                 410                 415     


His Glu Leu Lys Phe Arg Ser Ala Arg Tyr Ser Arg Ser Leu Ser Thr 
            420                 425                 430         


Glu Phe Leu Asn 
        435     


<210>  5729
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNG4__Homo_sapiens__NP_758857

<400>  5729

Met Pro Met Pro Ser Arg Asp Gly Gly Leu His Pro Arg His His His 
1               5                   10                  15      


Tyr Gly Ser His Ser Pro Trp Ser Gln Leu Leu Ser Ser Pro Met Glu 
            20                  25                  30          


Thr Pro Ser Ile Lys Gly Leu Tyr Tyr Arg Arg Val Arg Lys Val Gly 
        35                  40                  45              


Ala Leu Asp Ala Ser Pro Val Asp Leu Lys Lys Glu Ile Leu Ile Asn 
    50                  55                  60                  


Val Gly Gly Arg Arg Tyr Leu Leu Pro Trp Ser Thr Leu Asp Arg Phe 
65                  70                  75                  80  


Pro Leu Ser Arg Leu Ser Lys Leu Arg Leu Cys Arg Ser Tyr Glu Glu 
                85                  90                  95      


Ile Val Gln Leu Cys Asp Asp Tyr Asp Glu Asp Ser Gln Glu Phe Phe 
            100                 105                 110         


Phe Asp Arg Ser Pro Ser Ala Phe Gly Val Ile Val Ser Phe Leu Ala 
        115                 120                 125             


Ala Gly Lys Leu Val Leu Leu Gln Glu Met Cys Ala Leu Ser Phe Gln 
    130                 135                 140                 


Glu Glu Leu Ala Tyr Trp Gly Ile Glu Glu Ala His Leu Glu Arg Cys 
145                 150                 155                 160 


Cys Leu Arg Lys Leu Leu Arg Lys Leu Glu Glu Leu Glu Glu Leu Ala 
                165                 170                 175     


Lys Leu His Arg Glu Asp Val Leu Arg Gln Gln Arg Glu Thr Arg Arg 
            180                 185                 190         


Pro Ala Ser His Ser Ser Arg Trp Gly Leu Cys Met Asn Arg Leu Arg 
        195                 200                 205             


Glu Met Val Glu Asn Pro Gln Ser Gly Leu Pro Gly Lys Val Phe Ala 
    210                 215                 220                 


Cys Leu Ser Ile Leu Phe Val Ala Thr Thr Ala Val Ser Leu Cys Val 
225                 230                 235                 240 


Ser Thr Met Pro Asp Leu Arg Ala Glu Glu Asp Gln Gly Glu Cys Ser 
                245                 250                 255     


Arg Lys Cys Tyr Tyr Ile Phe Ile Val Glu Thr Ile Cys Val Ala Trp 
            260                 265                 270         


Phe Ser Leu Glu Phe Cys Leu Arg Phe Val Gln Ala Gln Asp Lys Cys 
        275                 280                 285             


Gln Phe Phe Gln Gly Pro Leu Asn Ile Ile Asp Ile Leu Ala Ile Ser 
    290                 295                 300                 


Pro Tyr Tyr Val Ser Leu Ala Val Ser Glu Glu Pro Pro Glu Asp Gly 
305                 310                 315                 320 


Glu Arg Pro Ser Gly Ser Ser Tyr Leu Glu Lys Val Gly Leu Val Leu 
                325                 330                 335     


Arg Val Leu Arg Ala Leu Arg Ile Leu Tyr Val Met Arg Leu Ala Arg 
            340                 345                 350         


His Ser Leu Gly Leu Gln Thr Leu Gly Leu Thr Val Arg Arg Cys Thr 
        355                 360                 365             


Arg Glu Phe Gly Leu Leu Leu Leu Phe Leu Ala Val Ala Ile Thr Leu 
    370                 375                 380                 


Phe Ser Pro Leu Val Tyr Val Ala Glu Lys Glu Ser Gly Arg Val Leu 
385                 390                 395                 400 


Glu Phe Thr Ser Ile Pro Ala Ser Tyr Trp Trp Ala Ile Ile Ser Met 
                405                 410                 415     


Thr Thr Val Gly Tyr Gly Asp Met Val Pro Arg Ser Val Pro Gly Gln 
            420                 425                 430         


Met Val Ala Leu Ser Ser Ile Leu Ser Gly Ile Leu Ile Met Ala Phe 
        435                 440                 445             


Pro Ala Thr Ser Ile Phe His Thr Phe Ser His Ser Tyr Leu Glu Leu 
    450                 455                 460                 


Lys Lys Glu Gln Glu Gln Leu Gln Ala Arg Leu Arg His Leu Gln Asn 
465                 470                 475                 480 


Thr Gly Pro Ala Ser Glu Cys Glu Leu Leu Asp Pro His Val Ala Ser 
                485                 490                 495     


Glu His Glu Leu Met Asn Asp Val Asn Asp Leu Ile Leu Glu Gly Pro 
            500                 505                 510         


Ala Leu Pro Ile Met His Met 
        515                 


<210>  5730
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH1__Homo_sapiens__NP_002229

<400>  5730

Met Thr Met Ala Gly Gly Arg Arg Gly Leu Val Ala Pro Gln Asn Thr 
1               5                   10                  15      


Phe Leu Glu Asn Ile Val Arg Arg Ser Asn Asp Thr Asn Phe Val Leu 
            20                  25                  30          


Gly Asn Ala Gln Ile Val Asp Trp Pro Ile Val Tyr Ser Asn Asp Gly 
        35                  40                  45              


Phe Cys Lys Leu Ser Gly Tyr His Arg Ala Glu Val Met Gln Lys Ser 
    50                  55                  60                  


Ser Thr Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Asp Thr Ile 
65                  70                  75                  80  


Glu Lys Val Arg Gln Thr Phe Glu Asn Tyr Glu Met Asn Ser Phe Glu 
                85                  90                  95      


Ile Leu Met Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Phe Val Lys 
            100                 105                 110         


Ile Ala Pro Ile Arg Asn Glu Gln Asp Lys Val Val Leu Phe Leu Cys 
        115                 120                 125             


Thr Phe Ser Asp Ile Thr Ala Phe Lys Gln Pro Ile Glu Asp Asp Ser 
    130                 135                 140                 


Cys Lys Gly Trp Gly Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Ser 
145                 150                 155                 160 


Ser Arg Gly Val Leu Gln Gln Leu Ala Pro Ser Val Gln Lys Gly Glu 
                165                 170                 175     


Asn Val His Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser 
            180                 185                 190         


Asp Ile Leu Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His 
        195                 200                 205             


Ile Ile Leu His Tyr Cys Val Phe Lys Thr Thr Trp Asp Trp Ile Ile 
    210                 215                 220                 


Leu Ile Leu Thr Phe Tyr Thr Ala Ile Leu Val Pro Tyr Asn Val Ser 
225                 230                 235                 240 


Phe Lys Thr Arg Gln Asn Asn Val Ala Trp Leu Val Val Asp Ser Ile 
                245                 250                 255     


Val Asp Val Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr 
            260                 265                 270         


Phe Val Gly Pro Ala Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg 
        275                 280                 285             


Met Asn Tyr Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu 
    290                 295                 300                 


Pro Tyr Asp Val Ile Asn Ala Phe Glu Asn Val Asp Glu Gly Ile Ser 
305                 310                 315                 320 


Ser Leu Phe Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg 
                325                 330                 335     


Val Ala Arg Lys Leu Asp His Tyr Ile Glu Tyr Gly Ala Ala Val Leu 
            340                 345                 350         


Val Leu Leu Val Cys Val Phe Gly Leu Ala Ala His Trp Met Ala Cys 
        355                 360                 365             


Ile Trp Tyr Ser Ile Gly Asp Tyr Glu Ile Phe Asp Glu Asp Thr Lys 
    370                 375                 380                 


Thr Ile Arg Asn Asn Ser Trp Leu Tyr Gln Leu Ala Met Asp Ile Gly 
385                 390                 395                 400 


Thr Pro Tyr Gln Phe Asn Gly Ser Gly Ser Gly Lys Trp Glu Gly Gly 
                405                 410                 415     


Pro Ser Lys Asn Ser Val Tyr Ile Ser Ser Leu Tyr Phe Thr Met Thr 
            420                 425                 430         


Ser Leu Thr Ser Val Gly Phe Gly Asn Ile Ala Pro Ser Thr Asp Ile 
        435                 440                 445             


Glu Lys Ile Phe Ala Val Ala Ile Met Met Ile Gly Ser Leu Leu Tyr 
    450                 455                 460                 


Ala Thr Ile Phe Gly Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala 
465                 470                 475                 480 


Asn Thr Asn Arg Tyr His Glu Met Leu Asn Ser Val Arg Asp Phe Leu 
                485                 490                 495     


Lys Leu Tyr Gln Val Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr 
            500                 505                 510         


Ile Val Ser Thr Trp Ser Met Ser Arg Gly Ile Asp Thr Glu Lys Val 
        515                 520                 525             


Leu Gln Ile Cys Pro Lys Asp Met Arg Ala Asp Ile Cys Val His Leu 
    530                 535                 540                 


Asn Arg Lys Val Phe Lys Glu His Pro Ala Phe Arg Leu Ala Ser Asp 
545                 550                 555                 560 


Gly Cys Leu Arg Ala Leu Ala Met Glu Phe Gln Thr Val His Cys Ala 
                565                 570                 575     


Pro Gly Asp Leu Ile Tyr His Ala Gly Glu Ser Val Asp Ser Leu Cys 
            580                 585                 590         


Phe Val Val Ser Gly Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val 
        595                 600                 605             


Ala Ile Leu Gly Lys Gly Asp Val Phe Gly Asp Val Phe Trp Lys Glu 
    610                 615                 620                 


Ala Thr Leu Ala Gln Ser Cys Ala Asn Val Arg Ala Leu Thr Tyr Cys 
625                 630                 635                 640 


Asp Leu His Val Ile Lys Arg Asp Ala Leu Gln Lys Val Leu Glu Phe 
                645                 650                 655     


Tyr Thr Ala Phe Ser His Ser Phe Ser Arg Asn Leu Ile Leu Thr Tyr 
            660                 665                 670         


Asn Leu Arg Lys Arg Ile Val Phe Arg Lys Ile Ser Asp Val Lys Arg 
        675                 680                 685             


Glu Glu Glu Glu Arg Met Lys Arg Lys Asn Glu Ala Pro Leu Ile Leu 
    690                 695                 700                 


Pro Pro Asp His Pro Val Arg Arg Leu Phe Gln Arg Phe Arg Gln Gln 
705                 710                 715                 720 


Lys Glu Ala Arg Leu Ala Ala Glu Arg Gly Gly Arg Asp Leu Asp Asp 
                725                 730                 735     


Leu Asp Val Glu Lys Gly Asn Val Leu Thr Glu His Ala Ser Ala Asn 
            740                 745                 750         


His Ser Leu Val Lys Ala Ser Val Val Thr Val Arg Glu Ser Pro Ala 
        755                 760                 765             


Thr Pro Val Ser Phe Gln Ala Ala Ser Thr Ser Gly Val Pro Asp His 
    770                 775                 780                 


Ala Lys Leu Gln Ala Pro Gly Ser Glu Cys Leu Gly Pro Lys Gly Gly 
785                 790                 795                 800 


Gly Gly Asp Cys Ala Lys Arg Lys Ser Trp Ala Arg Phe Lys Asp Ala 
                805                 810                 815     


Cys Gly Lys Ser Glu Asp Trp Asn Lys Val Ser Lys Ala Glu Ser Met 
            820                 825                 830         


Glu Thr Leu Pro Glu Arg Thr Lys Ala Ser Gly Glu Ala Thr Leu Lys 
        835                 840                 845             


Lys Thr Asp Ser Cys Asp Ser Gly Ile Thr Lys Ser Asp Leu Arg Leu 
    850                 855                 860                 


Asp Asn Val Gly Glu Ala Arg Ser Pro Gln Asp Arg Ser Pro Ile Leu 
865                 870                 875                 880 


Ala Glu Val Lys His Ser Phe Tyr Pro Ile Pro Glu Gln Thr Leu Gln 
                885                 890                 895     


Ala Thr Val Leu Glu Val Arg His Glu Leu Lys Glu Asp Ile Lys Ala 
            900                 905                 910         


Leu Asn Ala Lys Met Thr Asn Ile Glu Lys Gln Leu Ser Glu Ile Leu 
        915                 920                 925             


Arg Ile Leu Thr Ser Arg Arg Ser Ser Gln Ser Pro Gln Glu Leu Phe 
    930                 935                 940                 


Glu Ile Ser Arg Pro Gln Ser Pro Glu Ser Glu Arg Asp Ile Phe Gly 
945                 950                 955                 960 


Ala Ser 
        


<210>  5731
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH2__Homo_sapiens__NP_000229

<400>  5731

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210>  5732
<211>  1083
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH3__Homo_sapiens__NP_036416

<400>  5732

Met Pro Ala Met Arg Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Val Leu Gly 
            20                  25                  30          


Asn Ala Gln Val Ala Gly Leu Phe Pro Val Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Asp Leu Thr Gly Phe Ser Arg Ala Glu Val Met Gln Arg Gly 
    50                  55                  60                  


Cys Ala Cys Ser Phe Leu Tyr Gly Pro Asp Thr Ser Glu Leu Val Arg 
65                  70                  75                  80  


Gln Gln Ile Arg Lys Ala Leu Asp Glu His Lys Glu Phe Lys Ala Glu 
                85                  90                  95      


Leu Ile Leu Tyr Arg Lys Ser Gly Leu Pro Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Val Ile Pro Ile Lys Asn Glu Lys Gly Glu Val Ala Leu Phe Leu Val 
        115                 120                 125             


Ser His Lys Asp Ile Ser Glu Thr Lys Asn Arg Gly Gly Pro Asp Arg 
    130                 135                 140                 


Trp Lys Glu Thr Gly Gly Gly Arg Arg Arg Tyr Gly Arg Ala Arg Ser 
145                 150                 155                 160 


Lys Gly Phe Asn Ala Asn Arg Arg Arg Ser Arg Ala Val Leu Tyr His 
                165                 170                 175     


Leu Ser Gly His Leu Gln Lys Gln Pro Lys Gly Lys His Lys Leu Asn 
            180                 185                 190         


Lys Gly Val Phe Gly Glu Lys Pro Asn Leu Pro Glu Tyr Lys Val Ala 
        195                 200                 205             


Ala Ile Arg Lys Ser Pro Phe Ile Leu Leu His Cys Gly Ala Leu Arg 
    210                 215                 220                 


Ala Thr Trp Asp Gly Phe Ile Leu Leu Ala Thr Leu Tyr Val Ala Val 
225                 230                 235                 240 


Thr Val Pro Tyr Ser Val Cys Val Ser Thr Ala Arg Glu Pro Ser Ala 
                245                 250                 255     


Ala Arg Gly Pro Pro Ser Val Cys Asp Leu Ala Val Glu Val Leu Phe 
            260                 265                 270         


Ile Leu Asp Ile Val Leu Asn Phe Arg Thr Thr Phe Val Ser Lys Ser 
        275                 280                 285             


Gly Gln Val Val Phe Ala Pro Lys Ser Ile Cys Leu His Tyr Val Thr 
    290                 295                 300                 


Thr Trp Phe Leu Leu Asp Val Ile Ala Ala Leu Pro Phe Asp Leu Leu 
305                 310                 315                 320 


His Ala Phe Lys Val Asn Val Tyr Phe Gly Ala His Leu Leu Lys Thr 
                325                 330                 335     


Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Pro Arg Leu Asp Arg Tyr 
            340                 345                 350         


Ser Gln Tyr Ser Ala Val Val Leu Thr Leu Leu Met Ala Val Phe Ala 
        355                 360                 365             


Leu Leu Ala His Trp Val Ala Cys Val Trp Phe Tyr Ile Gly Gln Arg 
    370                 375                 380                 


Glu Ile Glu Ser Ser Glu Ser Glu Leu Pro Glu Ile Gly Trp Leu Gln 
385                 390                 395                 400 


Glu Leu Ala Arg Arg Leu Glu Thr Pro Tyr Tyr Leu Val Gly Arg Arg 
                405                 410                 415     


Pro Ala Gly Gly Asn Ser Ser Gly Gln Ser Asp Asn Cys Ser Ser Ser 
            420                 425                 430         


Ser Glu Ala Asn Gly Thr Gly Leu Glu Leu Leu Gly Gly Pro Ser Leu 
        435                 440                 445             


Arg Ser Ala Tyr Ile Thr Ser Leu Tyr Phe Ala Leu Ser Ser Leu Thr 
    450                 455                 460                 


Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Thr Glu Lys Ile 
465                 470                 475                 480 


Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Val Val 
                485                 490                 495     


Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ala Arg Arg Phe 
            500                 505                 510         


Leu Tyr His Ser Arg Thr Arg Asp Leu Arg Asp Tyr Ile Arg Ile His 
        515                 520                 525             


Arg Ile Pro Lys Pro Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln Ala 
    530                 535                 540                 


Thr Trp Ala Val Asn Asn Gly Ile Asp Thr Thr Glu Leu Leu Gln Ser 
545                 550                 555                 560 


Leu Pro Asp Glu Leu Arg Ala Asp Ile Ala Met His Leu His Lys Glu 
                565                 570                 575     


Val Leu Gln Leu Pro Leu Phe Glu Ala Ala Ser Arg Gly Cys Leu Arg 
            580                 585                 590         


Ala Leu Ser Leu Ala Leu Arg Pro Ala Phe Cys Thr Pro Gly Glu Tyr 
        595                 600                 605             


Leu Ile His Gln Gly Asp Ala Leu Gln Ala Leu Tyr Phe Val Cys Ser 
    610                 615                 620                 


Gly Ser Met Glu Val Leu Lys Gly Gly Thr Val Leu Ala Ile Leu Gly 
625                 630                 635                 640 


Lys Gly Asp Leu Ile Gly Cys Glu Leu Pro Arg Arg Glu Gln Val Val 
                645                 650                 655     


Lys Ala Asn Ala Asp Val Lys Gly Leu Thr Tyr Cys Val Leu Gln Cys 
            660                 665                 670         


Leu Gln Leu Ala Gly Leu His Asp Ser Leu Ala Leu Tyr Pro Glu Phe 
        675                 680                 685             


Ala Pro Arg Phe Ser Arg Gly Leu Arg Gly Glu Leu Ser Tyr Asn Leu 
    690                 695                 700                 


Gly Ala Gly Gly Gly Ser Ala Glu Val Asp Thr Ser Ser Leu Ser Gly 
705                 710                 715                 720 


Asp Asn Thr Leu Met Ser Thr Leu Glu Glu Lys Glu Thr Asp Gly Glu 
                725                 730                 735     


Gln Gly Pro Thr Val Ser Pro Ala Pro Ala Asp Glu Pro Ser Ser Pro 
            740                 745                 750         


Leu Leu Ser Pro Gly Cys Thr Ser Ser Ser Ser Ala Ala Lys Leu Leu 
        755                 760                 765             


Ser Pro Arg Arg Thr Ala Pro Arg Pro Arg Leu Gly Gly Arg Gly Arg 
    770                 775                 780                 


Pro Gly Arg Ala Gly Ala Leu Lys Ala Glu Ala Gly Pro Ser Ala Pro 
785                 790                 795                 800 


Pro Arg Ala Leu Glu Gly Leu Arg Leu Pro Pro Met Pro Trp Asn Val 
                805                 810                 815     


Pro Pro Asp Leu Ser Pro Arg Val Val Asp Gly Ile Glu Asp Gly Cys 
            820                 825                 830         


Gly Ser Asp Gln Pro Lys Phe Ser Phe Arg Val Gly Gln Ser Gly Pro 
        835                 840                 845             


Glu Cys Ser Ser Ser Pro Ser Pro Gly Pro Glu Ser Gly Leu Leu Thr 
    850                 855                 860                 


Val Pro His Gly Pro Ser Glu Ala Arg Asn Thr Asp Thr Leu Asp Lys 
865                 870                 875                 880 


Leu Arg Gln Ala Val Thr Glu Leu Ser Glu Gln Val Leu Gln Met Arg 
                885                 890                 895     


Glu Gly Leu Gln Ser Leu Arg Gln Ala Val Gln Leu Val Leu Ala Pro 
            900                 905                 910         


His Arg Glu Gly Pro Cys Pro Arg Ala Ser Gly Glu Gly Pro Cys Pro 
        915                 920                 925             


Ala Ser Thr Ser Gly Leu Leu Gln Pro Leu Cys Val Asp Thr Gly Ala 
    930                 935                 940                 


Ser Ser Tyr Cys Leu Gln Pro Pro Ala Gly Ser Val Leu Ser Gly Thr 
945                 950                 955                 960 


Trp Pro His Pro Arg Pro Gly Pro Pro Pro Leu Met Ala Pro Trp Pro 
                965                 970                 975     


Trp Gly Pro Pro Ala Ser Gln Ser Ser Pro Trp Pro Arg Ala Thr Ala 
            980                 985                 990         


Phe Trp Thr Ser Thr Ser Asp Ser  Glu Pro Pro Ala Ser  Gly Asp Leu 
        995                 1000                 1005             


Cys Ser  Glu Pro Ser Thr Pro  Ala Ser Pro Pro Pro  Ser Glu Glu 
    1010                 1015                 1020             


Gly Ala  Arg Thr Gly Pro Ala  Glu Pro Val Ser Gln  Ala Glu Ala 
    1025                 1030                 1035             


Thr Ser  Thr Gly Glu Pro Pro  Pro Gly Ser Gly Gly  Leu Ala Leu 
    1040                 1045                 1050             


Pro Trp  Asp Pro His Ser Leu  Glu Met Val Leu Ile  Gly Cys His 
    1055                 1060                 1065             


Gly Ser  Gly Thr Val Gln Trp  Thr Gln Glu Glu Gly  Thr Gly Val 
    1070                 1075                 1080             


<210>  5733
<211>  1017
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH4__Homo_sapiens__NP_036417

<400>  5733

Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Leu Leu Ala 
            20                  25                  30          


Asn Ala Gln Gly Thr Arg Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Thr Gly Tyr Gly Arg Thr Glu Val Met Gln Lys Thr 
    50                  55                  60                  


Cys Ser Cys Arg Phe Leu Tyr Gly Pro Glu Thr Ser Glu Pro Ala Leu 
65                  70                  75                  80  


Gln Arg Leu His Lys Ala Leu Glu Gly His Gln Glu His Arg Ala Glu 
                85                  90                  95      


Ile Cys Phe Tyr Arg Lys Asp Gly Ser Ala Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Met Met Pro Ile Lys Asn Glu Met Gly Glu Val Val Leu Phe Leu Phe 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Gln Ser Gly Ser Pro Gly Leu Gly Pro Gln 
    130                 135                 140                 


Gly Gly Arg Gly Asp Ser Asn His Glu Asn Ser Leu Gly Arg Arg Gly 
145                 150                 155                 160 


Ala Thr Trp Lys Phe Arg Ser Ala Arg Arg Arg Ser Arg Thr Val Leu 
                165                 170                 175     


His Arg Leu Thr Gly His Phe Gly Arg Arg Gly Gln Gly Gly Met Lys 
            180                 185                 190         


Ala Asn Asn Asn Val Phe Glu Pro Lys Pro Ser Val Pro Glu Tyr Lys 
        195                 200                 205             


Val Ala Ser Val Gly Gly Ser Arg Cys Leu Leu Leu His Tyr Ser Val 
    210                 215                 220                 


Ser Lys Ala Ile Trp Asp Gly Leu Ile Leu Leu Ala Thr Phe Tyr Val 
225                 230                 235                 240 


Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ser Gly Asp Asp Asp Thr 
                245                 250                 255     


Pro Ile Thr Ser Arg His Thr Leu Val Ser Asp Ile Ala Val Glu Met 
            260                 265                 270         


Leu Phe Ile Leu Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser 
        275                 280                 285             


Gln Ser Gly Gln Val Ile Ser Ala Pro Arg Ser Ile Gly Leu His Tyr 
    290                 295                 300                 


Leu Ala Thr Trp Phe Phe Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Asn Ile Thr Val Thr Ser Leu Val His Leu Leu 
                325                 330                 335     


Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys Leu Glu 
            340                 345                 350         


Arg Tyr Ser Gln Cys Ser Ala Val Val Leu Thr Leu Leu Met Ser Val 
        355                 360                 365             


Phe Ala Leu Leu Ala His Trp Met Ala Cys Ile Trp Tyr Val Ile Gly 
    370                 375                 380                 


Arg Arg Glu Met Glu Ala Asn Asp Pro Leu Leu Trp Asp Ile Gly Trp 
385                 390                 395                 400 


Leu His Glu Leu Gly Lys Arg Leu Glu Val Pro Tyr Val Asn Gly Ser 
                405                 410                 415     


Val Gly Gly Pro Ser Arg Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe 
            420                 425                 430         


Thr Leu Ser Ser Leu Thr Ser Val Gly Phe Gly Asn Val Cys Ala Asn 
        435                 440                 445             


Thr Asp Ala Glu Lys Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala 
    450                 455                 460                 


Leu Met His Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg 
465                 470                 475                 480 


Met Tyr Ser Arg Arg Ser Leu Tyr His Ser Arg Met Lys Asp Leu Lys 
                485                 490                 495     


Asp Phe Ile Arg Val His Arg Leu Pro Arg Pro Leu Lys Gln Arg Met 
            500                 505                 510         


Leu Glu Tyr Phe Gln Thr Thr Trp Ala Val Asn Ser Gly Ile Asp Ala 
        515                 520                 525             


Asn Glu Leu Leu Arg Asp Phe Pro Asp Glu Leu Arg Ala Asp Ile Ala 
    530                 535                 540                 


Met His Leu Asn Arg Glu Ile Leu Gln Leu Pro Leu Phe Gly Ala Ala 
545                 550                 555                 560 


Ser Arg Gly Cys Leu Arg Ala Leu Ser Leu His Ile Lys Thr Ser Phe 
                565                 570                 575     


Cys Ala Pro Gly Glu Tyr Leu Leu Arg Arg Gly Asp Ala Leu Gln Ala 
            580                 585                 590         


His Tyr Tyr Val Cys Ser Gly Ser Leu Glu Val Leu Arg Asp Asn Met 
        595                 600                 605             


Val Leu Ala Ile Leu Gly Lys Gly Asp Leu Ile Gly Ala Asp Ile Pro 
    610                 615                 620                 


Glu Pro Gly Gln Glu Pro Gly Leu Gly Ala Asp Pro Asn Phe Val Leu 
625                 630                 635                 640 


Lys Thr Ser Ala Asp Val Lys Ala Leu Thr Tyr Cys Gly Leu Gln Gln 
                645                 650                 655     


Leu Ser Ser Arg Gly Leu Ala Glu Val Leu Arg Leu Tyr Pro Glu Tyr 
            660                 665                 670         


Gly Ala Ala Phe Arg Ala Gly Leu Pro Arg Asp Leu Thr Phe Asn Leu 
        675                 680                 685             


Arg Gln Gly Ser Asp Thr Ser Gly Leu Ser Arg Phe Ser Arg Ser Pro 
    690                 695                 700                 


Arg Leu Ser Gln Pro Arg Ser Glu Ser Leu Gly Ser Ser Ser Asp Lys 
705                 710                 715                 720 


Thr Leu Pro Ser Ile Thr Glu Ala Glu Ser Gly Ala Glu Pro Gly Gly 
                725                 730                 735     


Gly Pro Arg Pro Arg Arg Pro Leu Leu Leu Pro Asn Leu Ser Pro Ala 
            740                 745                 750         


Arg Pro Arg Gly Ser Leu Val Ser Leu Leu Gly Glu Glu Leu Pro Pro 
        755                 760                 765             


Phe Ser Ala Leu Val Ser Ser Pro Ser Leu Ser Pro Ser Leu Ser Pro 
    770                 775                 780                 


Ala Leu Ala Gly Gln Gly His Ser Ala Ser Pro His Gly Pro Pro Arg 
785                 790                 795                 800 


Cys Ser Ala Ala Trp Lys Pro Pro Gln Leu Leu Ile Pro Pro Leu Gly 
                805                 810                 815     


Thr Phe Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly Ile Glu 
            820                 825                 830         


Asp Ser Gly Ser Thr Ala Glu Ala Pro Ser Phe Arg Phe Ser Arg Arg 
        835                 840                 845             


Pro Glu Leu Pro Arg Pro Arg Ser Gln Ala Pro Pro Thr Gly Thr Arg 
    850                 855                 860                 


Pro Ser Pro Glu Leu Ala Ser Glu Ala Glu Glu Val Lys Glu Lys Val 
865                 870                 875                 880 


Cys Arg Leu Asn Gln Glu Ile Ser Arg Leu Asn Gln Glu Val Ser Gln 
                885                 890                 895     


Leu Ser Arg Glu Leu Arg His Ile Met Gly Leu Leu Gln Ala Arg Leu 
            900                 905                 910         


Gly Pro Pro Gly His Pro Ala Gly Ser Ala Trp Thr Pro Asp Pro Pro 
        915                 920                 925             


Cys Pro Gln Leu Arg Pro Pro Cys Leu Ser Pro Cys Ala Ser Arg Pro 
    930                 935                 940                 


Pro Pro Ser Leu Gln Asp Thr Thr Leu Ala Glu Val His Cys Pro Ala 
945                 950                 955                 960 


Ser Val Gly Thr Met Glu Thr Gly Thr Ala Leu Leu Asp Leu Arg Pro 
                965                 970                 975     


Ser Ile Leu Pro Pro Tyr Pro Ser Glu Pro Asp Pro Leu Gly Pro Ser 
            980                 985                 990         


Pro Val Pro Glu Ala Ser Pro Pro  Thr Pro Ser Leu Leu  Arg His Ser 
        995                 1000                 1005             


Phe Gln  Ser Arg Ser Asp Thr  Phe His 
    1010                 1015         


<210>  5734
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH5__Homo_sapiens__NP_647479

<400>  5734

Met Pro Gly Gly Lys Arg Gly Leu Val Ala Pro Gln Asn Thr Phe Leu 
1               5                   10                  15      


Glu Asn Ile Val Arg Arg Ser Ser Glu Ser Ser Phe Leu Leu Gly Asn 
            20                  25                  30          


Ala Gln Ile Val Asp Trp Pro Val Val Tyr Ser Asn Asp Gly Phe Cys 
        35                  40                  45              


Lys Leu Ser Gly Tyr His Arg Ala Asp Val Met Gln Lys Ser Ser Thr 
    50                  55                  60                  


Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Lys Thr Ile Glu Lys 
65                  70                  75                  80  


Val Arg Gln Thr Phe Asp Asn Tyr Glu Ser Asn Cys Phe Glu Val Leu 
                85                  90                  95      


Leu Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Tyr Met Gln Ile Ala 
            100                 105                 110         


Pro Ile Arg Asn Glu His Glu Lys Val Val Leu Phe Leu Cys Thr Phe 
        115                 120                 125             


Lys Asp Ile Thr Leu Phe Lys Gln Pro Ile Glu Asp Asp Ser Thr Lys 
    130                 135                 140                 


Gly Trp Thr Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Asn Ser Arg 
145                 150                 155                 160 


Ser Val Leu Gln Gln Leu Thr Pro Met Asn Lys Thr Glu Val Val His 
                165                 170                 175     


Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser Asp Ile Leu 
            180                 185                 190         


Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His Ile Ile Leu 
        195                 200                 205             


His Tyr Cys Ala Phe Lys Thr Thr Trp Asp Trp Val Ile Leu Ile Leu 
    210                 215                 220                 


Thr Phe Tyr Thr Ala Ile Met Val Pro Tyr Asn Val Ser Phe Lys Thr 
225                 230                 235                 240 


Lys Gln Asn Asn Ile Ala Trp Leu Val Leu Asp Ser Val Val Asp Val 
                245                 250                 255     


Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr Phe Val Gly 
            260                 265                 270         


Pro Gly Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg Met Asn Tyr 
        275                 280                 285             


Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu Pro Tyr Asp 
    290                 295                 300                 


Ile Ile Asn Ala Phe Glu Asn Val Asp Glu Gly Ile Ser Ser Leu Phe 
305                 310                 315                 320 


Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg Val Ala Arg 
                325                 330                 335     


Lys Leu Asp His Tyr Leu Glu Tyr Gly Ala Ala Val Leu Val Leu Leu 
            340                 345                 350         


Val Cys Val Phe Gly Leu Val Ala His Trp Leu Ala Cys Ile Trp Tyr 
        355                 360                 365             


Ser Ile Gly Asp Tyr Glu Val Ile Asp Glu Val Thr Asn Thr Ile Gln 
    370                 375                 380                 


Ile Asp Ser Trp Leu Tyr Gln Leu Ala Leu Ser Ile Gly Thr Pro Tyr 
385                 390                 395                 400 


Arg Tyr Asn Thr Ser Ala Gly Ile Trp Glu Gly Gly Pro Ser Lys Asp 
                405                 410                 415     


Ser Leu Tyr Val Ser Ser Leu Tyr Phe Thr Met Thr Ser Leu Thr Thr 
            420                 425                 430         


Ile Gly Phe Gly Asn Ile Ala Pro Thr Thr Asp Val Glu Lys Met Phe 
        435                 440                 445             


Ser Val Ala Met Met Met Val Gly Ser Leu Leu Tyr Ala Thr Ile Phe 
    450                 455                 460                 


Gly Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala Asn Thr Asn Arg 
465                 470                 475                 480 


Tyr His Glu Met Leu Asn Asn Val Arg Asp Phe Leu Lys Leu Tyr Gln 
                485                 490                 495     


Val Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr Ile Val Ser Thr 
            500                 505                 510         


Trp Ser Met Ser Lys Gly Ile Asp Thr Glu Lys Val Leu Ser Ile Cys 
        515                 520                 525             


Pro Lys Asp Met Arg Ala Asp Ile Cys Val His Leu Asn Arg Lys Val 
    530                 535                 540                 


Phe Asn Glu His Pro Ala Phe Arg Leu Ala Ser Asp Gly Cys Leu Arg 
545                 550                 555                 560 


Ala Leu Ala Val Glu Phe Gln Thr Ile His Cys Ala Pro Gly Asp Leu 
                565                 570                 575     


Ile Tyr His Ala Gly Glu Ser Val Asp Ala Leu Cys Phe Val Val Ser 
            580                 585                 590         


Gly Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val Ala Ile Leu Gly 
        595                 600                 605             


Lys Gly Asp Val Phe Gly Asp Ile Phe Trp Lys Glu Thr Thr Leu Ala 
    610                 615                 620                 


His Ala Cys Ala Asn Val Arg Ala Leu Thr Tyr Cys Asp Leu His Ile 
625                 630                 635                 640 


Ile Lys Arg Glu Ala Leu Leu Lys Val Leu Asp Phe Tyr Thr Ala Phe 
                645                 650                 655     


Ala Asn Ser Phe Ser Arg Asn Leu Thr Leu Thr Cys Asn Leu Arg Lys 
            660                 665                 670         


Arg Ile Ile Phe Arg Lys Ile Ser Asp Val Lys Lys Glu Glu Glu Glu 
        675                 680                 685             


Arg Leu Arg Gln Lys Asn Glu Val Thr Leu Ser Ile Pro Val Asp His 
    690                 695                 700                 


Pro Val Arg Lys Leu Phe Gln Lys Phe Lys Gln Gln Lys Glu Leu Arg 
705                 710                 715                 720 


Asn Gln Gly Ser Thr Gln Gly Asp Pro Glu Arg Asn Gln Leu Gln Val 
                725                 730                 735     


Glu Ser Arg Ser Leu Gln Asn Gly Ala Ser Ile Thr Gly Thr Ser Val 
            740                 745                 750         


Val Thr Val Ser Gln Ile Thr Pro Ile Gln Thr Ser Leu Ala Tyr Val 
        755                 760                 765             


Lys Thr Ser Glu Ser Leu Lys Gln Asn Asn Arg Asp Ala Met Glu Leu 
    770                 775                 780                 


Lys Pro Asn Gly Gly Ala Asp Gln Lys Cys Leu Lys Val Asn Ser Pro 
785                 790                 795                 800 


Ile Arg Met Lys Asn Gly Asn Gly Lys Gly Trp Leu Arg Leu Lys Asn 
                805                 810                 815     


Asn Met Gly Ala His Glu Glu Lys Lys Glu Asp Trp Asn Asn Val Thr 
            820                 825                 830         


Lys Ala Glu Ser Met Gly Leu Leu Ser Glu Asp Pro Lys Ser Ser Asp 
        835                 840                 845             


Ser Glu Asn Ser Val Thr Lys Asn Pro Leu Arg Lys Thr Asp Ser Cys 
    850                 855                 860                 


Asp Ser Gly Ile Thr Lys Ser Asp Leu Arg Leu Asp Lys Ala Gly Glu 
865                 870                 875                 880 


Ala Arg Ser Pro Leu Glu His Ser Pro Ile Gln Ala Asp Ala Lys His 
                885                 890                 895     


Pro Phe Tyr Pro Ile Pro Glu Gln Ala Leu Gln Thr Thr Leu Gln Glu 
            900                 905                 910         


Val Lys His Glu Leu Lys Glu Asp Ile Gln Leu Leu Ser Cys Arg Met 
        915                 920                 925             


Thr Ala Leu Glu Lys Gln Val Ala Glu Ile Leu Lys Ile Leu Ser Glu 
    930                 935                 940                 


Lys Ser Val Pro Gln Ala Ser Ser Pro Lys Ser Gln Met Pro Leu Gln 
945                 950                 955                 960 


Val Pro Pro Gln Ile Pro Cys Gln Asp Ile Phe Ser Val Ser Arg Pro 
                965                 970                 975     


Glu Ser Pro Glu Ser Asp Lys Asp Glu Ile His Phe 
            980                 985             


<210>  5735
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH6__Homo_sapiens__NP_110406

<400>  5735

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Tyr Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Leu Ile Ala 
            20                  25                  30          


Asn Ala Gln Met Glu Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Phe Gly Tyr Ser Arg Val Glu Val Met Gln Gln Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu Thr Gly Pro Asn Thr Pro Ser Ser Ala Val Ser 
65                  70                  75                  80  


Arg Leu Ala Gln Ala Leu Leu Gly Ala Glu Glu Cys Lys Val Asp Ile 
                85                  90                  95      


Leu Tyr Tyr Arg Lys Asp Ala Ser Ser Phe Arg Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Asp Leu Ala Gln Leu Leu Ala Lys Cys Ser Ser Arg Ser Leu 
    130                 135                 140                 


Ser Gln Arg Leu Leu Ser Gln Ser Phe Leu Gly Ser Glu Gly Ser His 
145                 150                 155                 160 


Gly Arg Pro Gly Gly Pro Gly Pro Gly Thr Gly Arg Gly Lys Tyr Arg 
                165                 170                 175     


Thr Ile Ser Gln Ile Pro Gln Phe Thr Leu Asn Phe Val Glu Phe Asn 
            180                 185                 190         


Leu Glu Lys His Arg Ser Ser Ser Thr Thr Glu Ile Glu Ile Ile Ala 
        195                 200                 205             


Pro His Lys Val Val Glu Arg Thr Gln Asn Val Thr Glu Lys Val Thr 
    210                 215                 220                 


Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln 
225                 230                 235                 240 


Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser Pro Phe Lys 
                245                 250                 255     


Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Val 
            260                 265                 270         


Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Ser Asp Gln Asp Glu Ser 
        275                 280                 285             


Arg Arg Gly Ala Cys Ser Tyr Thr Cys Ser Pro Leu Thr Val Val Asp 
    290                 295                 300                 


Leu Ile Val Asp Ile Met Phe Val Val Asp Ile Val Ile Asn Phe Arg 
305                 310                 315                 320 


Thr Thr Tyr Val Asn Thr Asn Asp Glu Val Val Ser His Pro Arg Arg 
                325                 330                 335     


Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala 
            340                 345                 350         


Ala Ile Pro Phe Asp Leu Leu Ile Phe Arg Thr Gly Ser Asp Glu Thr 
        355                 360                 365             


Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val 
    370                 375                 380                 


Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu Ala 
                405                 410                 415     


Cys Ile Trp Tyr Ala Ile Gly Asn Val Glu Arg Pro Tyr Leu Glu His 
            420                 425                 430         


Lys Ile Gly Trp Leu Asp Ser Leu Gly Val Gln Leu Gly Lys Arg Tyr 
        435                 440                 445             


Asn Gly Ser Asp Pro Ala Ser Gly Pro Ser Val Gln Asp Lys Tyr Val 
    450                 455                 460                 


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
465                 470                 475                 480 


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Val Phe Ser Ile Cys Val 
                485                 490                 495     


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
            500                 505                 510         


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln 
        515                 520                 525             


Met Leu Arg Val Lys Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
    530                 535                 540                 


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr 
545                 550                 555                 560 


Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu 
                565                 570                 575     


Gln Ala Asp Ile Cys Leu His Leu His Arg Ala Leu Leu Gln His Cys 
            580                 585                 590         


Pro Ala Phe Ser Gly Ala Gly Lys Gly Cys Leu Arg Ala Leu Ala Val 
        595                 600                 605             


Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Leu 
    610                 615                 620                 


Gly Asp Val Leu Ser Thr Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu 
625                 630                 635                 640 


Ile Leu Arg Asp Asp Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile 
                645                 650                 655     


Phe Gly Glu Pro Val Ser Leu His Ala Gln Pro Gly Lys Ser Ser Ala 
            660                 665                 670         


Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys Ile Gln Arg Ala 
        675                 680                 685             


Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Ala Phe Ala Glu Ser Phe 
    690                 695                 700                 


Trp Ser Lys Leu Glu Val Thr Phe Asn Leu Arg Asp Ala Ala Gly Gly 
705                 710                 715                 720 


Leu His Ser Ser Pro Arg Gln Ala Pro Gly Ser Gln Asp His Gln Gly 
                725                 730                 735     


Phe Phe Leu Ser Asp Asn Gln Ser Gly Ser Pro His Glu Leu Gly Pro 
            740                 745                 750         


Gln Phe Pro Ser Lys Gly Tyr Ser Leu Leu Gly Pro Gly Ser Gln Asn 
        755                 760                 765             


Ser Met Gly Ala Gly Pro Cys Ala Pro Gly His Pro Asp Ala Ala Pro 
    770                 775                 780                 


Pro Leu Ser Ile Ser Asp Ala Ser Gly Leu Trp Pro Glu Leu Leu Gln 
785                 790                 795                 800 


Glu Met Pro Pro Arg His Ser Pro Gln Ser Pro Gln Glu Asp Pro Asp 
                805                 810                 815     


Cys Trp Pro Leu Lys Leu Gly Ser Arg Leu Glu Gln Leu Gln Ala Gln 
            820                 825                 830         


Met Asn Arg Leu Glu Ser Arg Val Ser Ser Asp Leu Ser Arg Ile Leu 
        835                 840                 845             


Gln Leu Leu Gln Lys Pro Met Pro Gln Gly His Ala Ser Tyr Ile Leu 
    850                 855                 860                 


Glu Ala Pro Ala Ser Asn Asp Leu Ala Leu Val Pro Ile Ala Ser Glu 
865                 870                 875                 880 


Thr Thr Ser Pro Gly Pro Arg Leu Pro Gln Gly Phe Leu Pro Pro Ala 
                885                 890                 895     


Gln Thr Pro Ser Tyr Gly Asp Leu Asp Asp Cys Ser Pro Lys His Arg 
            900                 905                 910         


Asn Ser Ser Pro Arg Met Pro His Leu Ala Val Ala Thr Asp Lys Thr 
        915                 920                 925             


Leu Ala Pro Ser Ser Glu Gln Glu Gln Pro Glu Gly Leu Trp Pro Pro 
    930                 935                 940                 


Leu Ala Ser Pro Leu His Pro Leu Glu Val Gln Gly Leu Ile Cys Gly 
945                 950                 955                 960 


Pro Cys Phe Ser Ser Leu Pro Glu His Leu Gly Ser Val Pro Lys Gln 
                965                 970                 975     


Leu Asp Phe Gln Arg His Gly Ser Asp Pro Gly Phe Ala Gly Ser Trp 
            980                 985                 990         


Gly His 
        


<210>  5736
<211>  1196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH7__Homo_sapiens__NP_150375

<400>  5736

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 
                85                  90                  95      


Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 
            100                 105                 110         


Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 
        115                 120                 125             


Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 
    130                 135                 140                 


Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 
145                 150                 155                 160 


Lys Phe Pro Gly Leu Arg Val Leu Thr Tyr Arg Lys Gln Ser Leu Pro 
                165                 170                 175     


Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 
            180                 185                 190         


Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 
        195                 200                 205             


Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 
    210                 215                 220                 


Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 
225                 230                 235                 240 


Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 
                245                 250                 255     


Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 
            260                 265                 270         


Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 
        275                 280                 285             


Ile Phe Arg Asp Arg His Ala Ser Glu Asp Asn Gly Arg Asn Val Lys 
    290                 295                 300                 


Gly Pro Phe Asn His Ile Lys Ser Ser Leu Leu Gly Ser Thr Ser Asp 
305                 310                 315                 320 


Ser Asn Leu Asn Lys Tyr Ser Thr Ile Asn Lys Ile Pro Gln Leu Thr 
                325                 330                 335     


Leu Asn Phe Ser Glu Val Lys Thr Glu Lys Lys Asn Ser Ser Pro Pro 
            340                 345                 350         


Ser Ser Asp Lys Thr Ile Ile Ala Pro Lys Val Lys Asp Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Thr Pro Arg Ile Asn Lys Phe Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Ile Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Asn Asp Arg Glu Glu Gln Lys Arg Arg Glu Cys Gly Tyr Ser Cys 
        435                 440                 445             


Ser Pro Leu Asn Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Ile 
    450                 455                 460                 


Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Gln Asn Glu Glu 
465                 470                 475                 480 


Val Val Ser Asp Pro Ala Lys Ile Ala Ile His Tyr Phe Lys Gly Trp 
                485                 490                 495     


Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe 
            500                 505                 510         


Gly Ser Gly Ser Asp Glu Thr Thr Thr Leu Ile Gly Leu Leu Lys Thr 
        515                 520                 525             


Ala Arg Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr 
    530                 535                 540                 


Ser Glu Tyr Gly Ala Ala Val Leu Met Leu Leu Met Cys Ile Phe Ala 
545                 550                 555                 560 


Leu Ile Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Val 
                565                 570                 575     


Glu Arg Pro Tyr Leu Thr Asp Lys Ile Gly Trp Leu Asp Ser Leu Gly 
            580                 585                 590         


Gln Gln Ile Gly Lys Arg Tyr Asn Asp Ser Asp Ser Ser Ser Gly Pro 
        595                 600                 605             


Ser Ile Lys Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser 
    610                 615                 620                 


Leu Thr Ser Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu 
625                 630                 635                 640 


Lys Ile Phe Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala 
                645                 650                 655     


Ser Ile Phe Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly 
            660                 665                 670         


Thr Ala Arg Tyr His Met Gln Met Leu Arg Val Lys Glu Phe Ile Arg 
        675                 680                 685             


Phe His Gln Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe 
    690                 695                 700                 


Gln His Ala Trp Thr Tyr Thr Asn Gly Ile Asp Met Asn Met Val Leu 
705                 710                 715                 720 


Lys Gly Phe Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn 
                725                 730                 735     


Gln Thr Leu Leu Gln Asn Cys Lys Ala Phe Arg Gly Ala Ser Lys Gly 
            740                 745                 750         


Cys Leu Arg Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro 
        755                 760                 765             


Gly Asp Thr Leu Val His Cys Gly Asp Val Leu Thr Ala Leu Tyr Phe 
    770                 775                 780                 


Leu Ser Arg Gly Ser Ile Glu Ile Leu Lys Asp Asp Ile Val Val Ala 
785                 790                 795                 800 


Ile Leu Gly Lys Asn Asp Ile Phe Gly Glu Met Val His Leu Tyr Ala 
                805                 810                 815     


Lys Pro Gly Lys Ser Asn Ala Asp Val Arg Ala Leu Thr Tyr Cys Asp 
            820                 825                 830         


Leu His Lys Ile Gln Arg Glu Asp Leu Leu Glu Val Leu Asp Met Tyr 
        835                 840                 845             


Pro Glu Phe Ser Asp His Phe Leu Thr Asn Leu Glu Leu Thr Phe Asn 
    850                 855                 860                 


Leu Arg His Glu Ser Ala Lys Ala Asp Leu Leu Arg Ser Gln Ser Met 
865                 870                 875                 880 


Asn Asp Ser Glu Gly Asp Asn Cys Lys Leu Arg Arg Arg Lys Leu Ser 
                885                 890                 895     


Phe Glu Ser Glu Gly Glu Lys Glu Asn Ser Thr Asn Asp Pro Glu Asp 
            900                 905                 910         


Ser Ala Asp Thr Ile Arg His Tyr Gln Ser Ser Lys Arg His Phe Glu 
        915                 920                 925             


Glu Lys Lys Ser Arg Ser Ser Ser Phe Ile Ser Ser Ile Asp Asp Glu 
    930                 935                 940                 


Gln Lys Pro Leu Phe Ser Gly Ile Val Asp Ser Ser Pro Gly Ile Gly 
945                 950                 955                 960 


Lys Ala Ser Gly Leu Asp Phe Glu Glu Thr Val Pro Thr Ser Gly Arg 
                965                 970                 975     


Met His Ile Asp Lys Arg Ser His Ser Cys Lys Asp Ile Thr Asp Met 
            980                 985                 990         


Arg Ser Trp Glu Arg Glu Asn Ala  His Pro Gln Pro Glu  Asp Ser Ser 
        995                 1000                 1005             


Pro Ser  Ala Leu Gln Arg Ala  Ala Trp Gly Ile Ser  Glu Thr Glu 
    1010                 1015                 1020             


Ser Asp  Leu Thr Tyr Gly Glu  Val Glu Gln Arg Leu  Asp Leu Leu 
    1025                 1030                 1035             


Gln Glu  Gln Leu Asn Arg Leu  Glu Ser Gln Met Thr  Thr Asp Ile 
    1040                 1045                 1050             


Gln Thr  Ile Leu Gln Leu Leu  Gln Lys Gln Thr Thr  Val Val Pro 
    1055                 1060                 1065             


Pro Ala  Tyr Ser Met Val Thr  Ala Gly Ser Glu Tyr  Gln Arg Pro 
    1070                 1075                 1080             


Ile Ile  Gln Leu Met Arg Thr  Ser Gln Pro Glu Ala  Ser Ile Lys 
    1085                 1090                 1095             


Thr Asp  Arg Ser Phe Ser Pro  Ser Ser Gln Cys Pro  Glu Phe Leu 
    1100                 1105                 1110             


Asp Leu  Glu Lys Ser Lys Leu  Lys Ser Lys Glu Ser  Leu Ser Ser 
    1115                 1120                 1125             


Gly Val  His Leu Asn Thr Ala  Ser Glu Asp Asn Leu  Thr Ser Leu 
    1130                 1135                 1140             


Leu Lys  Gln Asp Ser Asp Leu  Ser Leu Glu Leu His  Leu Arg Gln 
    1145                 1150                 1155             


Arg Lys  Thr Tyr Val His Pro  Ile Arg His Pro Ser  Leu Pro Asp 
    1160                 1165                 1170             


Ser Ser  Leu Ser Thr Val Gly  Ile Val Gly Leu His  Arg His Val 
    1175                 1180                 1185             


Ser Asp  Pro Gly Leu Pro Gly  Lys 
    1190                 1195     


<210>  5737
<211>  1107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNH8__Homo_sapiens__NP_653234

<400>  5737

Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Ile Leu Ala 
            20                  25                  30          


Asn Ala Gln Val Ala Lys Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Ala Gly Phe Ala Arg Thr Glu Val Met Gln Lys Ser 
    50                  55                  60                  


Cys Ser Cys Lys Phe Leu Phe Gly Val Glu Thr Asn Glu Gln Leu Met 
65                  70                  75                  80  


Leu Gln Ile Glu Lys Ser Leu Glu Glu Lys Thr Glu Phe Lys Gly Glu 
                85                  90                  95      


Ile Met Phe Tyr Lys Lys Asn Gly Ser Pro Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Ile Val Pro Ile Lys Asn Glu Lys Gly Asp Val Val Leu Phe Leu Ala 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Asp Thr Lys Val Lys Ile Thr Pro Glu Asp 
    130                 135                 140                 


Lys Lys Glu Asp Lys Val Lys Gly Arg Ser Arg Ala Gly Thr His Phe 
145                 150                 155                 160 


Asp Ser Ala Arg Arg Arg Ser Arg Ala Val Leu Tyr His Ile Ser Gly 
                165                 170                 175     


His Leu Gln Arg Arg Glu Lys Asn Lys Leu Lys Ile Asn Asn Asn Val 
            180                 185                 190         


Phe Val Asp Lys Pro Ala Phe Pro Glu Tyr Lys Val Ser Asp Ala Lys 
        195                 200                 205             


Lys Ser Lys Phe Ile Leu Leu His Phe Ser Thr Phe Lys Ala Gly Trp 
    210                 215                 220                 


Asp Trp Leu Ile Leu Leu Ala Thr Phe Tyr Val Ala Val Thr Val Pro 
225                 230                 235                 240 


Tyr Asn Val Cys Phe Ile Gly Asn Asp Asp Leu Ser Thr Thr Arg Ser 
                245                 250                 255     


Thr Thr Val Ser Asp Ile Ala Val Glu Ile Leu Phe Ile Ile Asp Ile 
            260                 265                 270         


Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser Lys Ser Gly Gln Val Ile 
        275                 280                 285             


Phe Glu Ala Arg Ser Ile Cys Ile His Tyr Val Thr Thr Trp Phe Ile 
    290                 295                 300                 


Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp Leu Leu Tyr Ala Phe Asn 
305                 310                 315                 320 


Val Thr Val Val Ser Leu Val His Leu Leu Lys Thr Val Arg Leu Leu 
                325                 330                 335     


Arg Leu Leu Arg Leu Leu Gln Lys Leu Asp Arg Tyr Ser Gln His Ser 
            340                 345                 350         


Thr Ile Val Leu Thr Leu Leu Met Ser Met Phe Ala Leu Leu Ala His 
        355                 360                 365             


Trp Met Ala Cys Ile Trp Tyr Val Ile Gly Lys Met Glu Arg Glu Asp 
    370                 375                 380                 


Asn Ser Leu Leu Lys Trp Glu Val Gly Trp Leu His Glu Leu Gly Lys 
385                 390                 395                 400 


Arg Leu Glu Ser Pro Tyr Tyr Gly Asn Asn Thr Leu Gly Gly Pro Ser 
                405                 410                 415     


Ile Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe Thr Leu Ser Ser Leu 
            420                 425                 430         


Thr Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Ala Glu Lys 
        435                 440                 445             


Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Leu 
    450                 455                 460                 


Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ser Arg Trp 
465                 470                 475                 480 


Ser Leu Tyr His Thr Arg Thr Lys Asp Leu Lys Asp Phe Ile Arg Val 
                485                 490                 495     


His His Leu Pro Gln Gln Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln 
            500                 505                 510         


Thr Thr Trp Ser Val Asn Asn Gly Ile Asp Ser Asn Glu Leu Leu Lys 
        515                 520                 525             


Asp Phe Pro Asp Glu Leu Arg Ser Asp Ile Thr Met His Leu Asn Lys 
    530                 535                 540                 


Glu Ile Leu Gln Leu Ser Leu Phe Glu Cys Ala Ser Arg Gly Cys Leu 
545                 550                 555                 560 


Arg Ser Leu Ser Leu His Ile Lys Thr Ser Phe Cys Ala Pro Gly Glu 
                565                 570                 575     


Tyr Leu Leu Arg Gln Gly Asp Ala Leu Gln Ala Ile Tyr Phe Val Cys 
            580                 585                 590         


Ser Gly Ser Met Glu Val Leu Lys Asp Ser Met Val Leu Ala Ile Leu 
        595                 600                 605             


Gly Lys Gly Asp Leu Ile Gly Ala Asn Leu Ser Ile Lys Asp Gln Val 
    610                 615                 620                 


Ile Lys Thr Asn Ala Asp Val Lys Ala Leu Thr Tyr Cys Asp Leu Gln 
625                 630                 635                 640 


Cys Ile Ile Leu Lys Gly Leu Phe Glu Val Leu Asp Leu Tyr Pro Glu 
                645                 650                 655     


Tyr Ala His Lys Phe Val Glu Asp Ile Gln His Asp Leu Thr Tyr Asn 
            660                 665                 670         


Leu Arg Glu Gly His Glu Ser Asp Val Ile Ser Arg Leu Ser Asn Lys 
        675                 680                 685             


Ser Met Val Ser Gln Ser Glu Pro Lys Gly Asn Gly Asn Ile Asn Lys 
    690                 695                 700                 


Arg Leu Pro Ser Ile Val Glu Asp Glu Glu Glu Glu Glu Glu Gly Glu 
705                 710                 715                 720 


Glu Glu Glu Ala Val Ser Leu Ser Pro Ile Cys Thr Arg Gly Ser Ser 
                725                 730                 735     


Ser Arg Asn Lys Lys Val Gly Ser Asn Lys Ala Tyr Leu Gly Leu Ser 
            740                 745                 750         


Leu Lys Gln Leu Ala Ser Gly Thr Val Pro Phe His Ser Pro Ile Arg 
        755                 760                 765             


Val Ser Arg Ser Asn Ser Pro Lys Thr Lys Gln Glu Ile Asp Pro Pro 
    770                 775                 780                 


Asn His Asn Lys Arg Lys Glu Lys Asn Leu Lys Leu Gln Leu Ser Thr 
785                 790                 795                 800 


Leu Asn Asn Ala Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly 
                805                 810                 815     


Ile Glu Asp Gly Asn Ser Ser Glu Glu Ser Gln Thr Phe Asp Phe Gly 
            820                 825                 830         


Ser Glu Arg Ile Arg Ser Glu Pro Arg Ile Ser Pro Pro Leu Gly Asp 
        835                 840                 845             


Pro Glu Ile Gly Ala Ala Val Leu Phe Ile Lys Ala Glu Glu Thr Lys 
    850                 855                 860                 


Gln Gln Ile Asn Lys Leu Asn Ser Glu Val Thr Thr Leu Thr Gln Glu 
865                 870                 875                 880 


Val Ser Gln Leu Gly Lys Asp Met Arg Asn Val Ile Gln Leu Leu Glu 
                885                 890                 895     


Asn Val Leu Ser Pro Gln Gln Pro Ser Arg Phe Cys Ser Leu His Ser 
            900                 905                 910         


Thr Ser Val Cys Pro Ser Arg Glu Ser Leu Gln Thr Arg Thr Ser Trp 
        915                 920                 925             


Ser Ala His Gln Pro Cys Leu His Leu Gln Thr Gly Gly Ala Ala Tyr 
    930                 935                 940                 


Thr Gln Ala Gln Leu Cys Ser Ser Asn Ile Thr Ser Asp Ile Trp Ser 
945                 950                 955                 960 


Val Asp Pro Ser Ser Val Gly Ser Ser Pro Gln Arg Thr Gly Ala His 
                965                 970                 975     


Glu Gln Asn Pro Ala Asp Ser Glu Leu Tyr His Ser Pro Ser Leu Asp 
            980                 985                 990         


Tyr Ser Pro Ser His Tyr Gln Val  Val Gln Glu Gly His  Leu Gln Phe 
        995                 1000                 1005             


Leu Arg  Cys Ile Ser Pro His  Ser Asp Ser Thr Leu  Thr Pro Leu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Ala Thr Leu  Ser Ser Ser Val Cys  Ser Ser Ser 
    1025                 1030                 1035             


Glu Thr  Ser Leu His Leu Val  Leu Pro Ser Arg Ser  Glu Glu Gly 
    1040                 1045                 1050             


Ser Phe  Ser Gln Gly Thr Val  Ser Ser Phe Ser Leu  Glu Asn Leu 
    1055                 1060                 1065             


Pro Gly  Ser Trp Asn Gln Glu  Gly Met Ala Ser Ala  Ser Thr Lys 
    1070                 1075                 1080             


Pro Leu  Glu Asn Leu Pro Leu  Glu Val Val Thr Ser  Thr Ala Glu 
    1085                 1090                 1095             


Val Lys  Asp Asn Lys Ala Ile  Asn Val 
    1100                 1105         


<210>  5738
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNIP1__Homo_sapiens__NP_001030009

<400>  5738

Met Gly Ala Val Met Gly Thr Phe Ser Ser Leu Gln Thr Lys Gln Arg 
1               5                   10                  15      


Arg Pro Ser Lys Asp Ile Ala Trp Trp Tyr Tyr Gln Tyr Gln Arg Asp 
            20                  25                  30          


Lys Ile Glu Asp Glu Leu Glu Met Thr Met Val Cys His Arg Pro Glu 
        35                  40                  45              


Gly Leu Glu Gln Leu Glu Ala Gln Thr Asn Phe Thr Lys Arg Glu Leu 
    50                  55                  60                  


Gln Val Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Ser Gly Val Val 
65                  70                  75                  80  


Asn Glu Asp Thr Phe Lys Gln Ile Tyr Ala Gln Phe Phe Pro His Gly 
                85                  90                  95      


Asp Ala Ser Thr Tyr Ala His Tyr Leu Phe Asn Ala Phe Asp Thr Thr 
            100                 105                 110         


Gln Thr Gly Ser Val Lys Phe Glu Asp Phe Val Thr Ala Leu Ser Ile 
        115                 120                 125             


Leu Leu Arg Gly Thr Val His Glu Lys Leu Arg Trp Thr Phe Asn Leu 
    130                 135                 140                 


Tyr Asp Ile Asn Lys Asp Gly Tyr Ile Asn Lys Glu Glu Met Met Asp 
145                 150                 155                 160 


Ile Val Lys Ala Ile Tyr Asp Met Met Gly Lys Tyr Thr Tyr Pro Val 
                165                 170                 175     


Leu Lys Glu Asp Thr Pro Arg Gln His Val Asp Val Phe Phe Gln Lys 
            180                 185                 190         


Met Asp Lys Asn Lys Asp Gly Ile Val Thr Leu Asp Glu Phe Leu Glu 
        195                 200                 205             


Ser Cys Gln Glu Asp Asp Asn Ile Met Arg Ser Leu Gln Leu Phe Gln 
    210                 215                 220                 


Asn Val Met 
225         


<210>  5739
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNIP2__Homo_sapiens__NP_055406

<400>  5739

Met Arg Gly Gln Gly Arg Lys Glu Ser Leu Ser Asp Ser Arg Asp Leu 
1               5                   10                  15      


Asp Gly Ser Tyr Asp Gln Leu Thr Gly His Pro Pro Gly Pro Thr Lys 
            20                  25                  30          


Lys Ala Leu Lys Gln Arg Phe Leu Lys Leu Leu Pro Cys Cys Gly Pro 
        35                  40                  45              


Gln Ala Leu Pro Ser Val Ser Glu Ile Gly Arg Val Phe Arg Phe Leu 
    50                  55                  60                  


Gly Asp Ser Ser Leu Pro Ser Ala Leu Ala Ala Pro Ala Ser Leu Arg 
65                  70                  75                  80  


Pro His Arg Pro Arg Leu Leu Asp Pro Asp Ser Val Asp Asp Glu Phe 
                85                  90                  95      


Glu Leu Ser Thr Val Cys His Arg Pro Glu Gly Leu Glu Gln Leu Gln 
            100                 105                 110         


Glu Gln Thr Lys Phe Thr Arg Lys Glu Leu Gln Val Leu Tyr Arg Gly 
        115                 120                 125             


Phe Lys Asn Glu Cys Pro Ser Gly Ile Val Asn Glu Glu Asn Phe Lys 
    130                 135                 140                 


Gln Ile Tyr Ser Gln Phe Phe Pro Gln Gly Asp Ser Ser Thr Tyr Ala 
145                 150                 155                 160 


Thr Phe Leu Phe Asn Ala Phe Asp Thr Asn His Asp Gly Ser Val Ser 
                165                 170                 175     


Phe Glu Asp Phe Val Ala Gly Leu Ser Val Ile Leu Arg Gly Thr Val 
            180                 185                 190         


Asp Asp Arg Leu Asn Trp Ala Phe Asn Leu Tyr Asp Leu Asn Lys Asp 
        195                 200                 205             


Gly Cys Ile Thr Lys Glu Glu Met Leu Asp Ile Met Lys Ser Ile Tyr 
    210                 215                 220                 


Asp Met Met Gly Lys Tyr Thr Tyr Pro Ala Leu Arg Glu Glu Ala Pro 
225                 230                 235                 240 


Arg Glu His Val Glu Ser Phe Phe Gln Lys Met Asp Arg Asn Lys Asp 
                245                 250                 255     


Gly Val Val Thr Ile Glu Glu Phe Ile Glu Ser Cys Gln Lys Asp Glu 
            260                 265                 270         


Asn Ile Met Arg Ser Met Gln Leu Phe Asp Asn Val Ile 
        275                 280                 285 


<210>  5740
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNIP3__Homo_sapiens__NP_001030086

<400>  5740

Met Gly Ile Gln Gly Met Glu Leu Cys Ala Met Ala Val Val Val Leu 
1               5                   10                  15      


Leu Phe Ile Ala Val Leu Lys Gln Phe Gly Ile Leu Glu Pro Ile Ser 
            20                  25                  30          


Met Glu Asp Ser Ser Asp Ser Glu Leu Glu Leu Ser Thr Val Arg His 
        35                  40                  45              


Gln Pro Glu Gly Leu Asp Gln Leu Gln Ala Gln Thr Lys Phe Thr Lys 
    50                  55                  60                  


Lys Glu Leu Gln Ser Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Thr 
65                  70                  75                  80  


Gly Leu Val Asp Glu Asp Thr Phe Lys Leu Ile Tyr Ala Gln Phe Phe 
                85                  90                  95      


Pro Gln Gly Asp Ala Thr Thr Tyr Ala His Phe Leu Phe Asn Ala Phe 
            100                 105                 110         


Asp Ala Asp Gly Asn Gly Ala Ile His Phe Glu Asp Phe Val Val Gly 
        115                 120                 125             


Leu Ser Ile Leu Leu Arg Gly Thr Val His Glu Lys Leu Lys Trp Ala 
    130                 135                 140                 


Phe Asn Leu Tyr Asp Ile Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu 
145                 150                 155                 160 


Met Leu Ala Ile Met Lys Ser Ile Tyr Asp Met Met Gly Arg His Thr 
                165                 170                 175     


Tyr Pro Ile Leu Arg Glu Asp Ala Pro Ala Glu His Val Glu Arg Phe 
            180                 185                 190         


Phe Glu Lys Met Asp Arg Asn Gln Asp Gly Val Val Thr Ile Glu Glu 
        195                 200                 205             


Phe Leu Glu Ala Cys Gln Lys Asp Glu Asn Ile Met Ser Ser Met Gln 
    210                 215                 220                 


Leu Phe Glu Asn Val Ile 
225                 230 


<210>  5741
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNIP4__Homo_sapiens__NP_001030175

<400>  5741

Met Ser Gly Cys Arg Lys Arg Cys Lys Arg Glu Ile Leu Lys Phe Ala 
1               5                   10                  15      


Gln Tyr Leu Leu Arg Leu Leu Thr Gly Ser Leu His Thr Asp Ser Val 
            20                  25                  30          


Glu Asp Glu Leu Glu Met Ala Thr Val Arg His Arg Pro Glu Ala Leu 
        35                  40                  45              


Glu Leu Leu Glu Ala Gln Ser Lys Phe Thr Lys Lys Glu Leu Gln Ile 
    50                  55                  60                  


Leu Tyr Arg Gly Phe Lys Asn Glu Cys Pro Ser Gly Val Val Asn Glu 
65                  70                  75                  80  


Glu Thr Phe Lys Glu Ile Tyr Ser Gln Phe Phe Pro Gln Gly Asp Ser 
                85                  90                  95      


Thr Thr Tyr Ala His Phe Leu Phe Asn Ala Phe Asp Thr Asp His Asn 
            100                 105                 110         


Gly Ala Val Ser Phe Glu Asp Phe Ile Lys Gly Leu Ser Ile Leu Leu 
        115                 120                 125             


Arg Gly Thr Val Gln Glu Lys Leu Asn Trp Ala Phe Asn Leu Tyr Asp 
    130                 135                 140                 


Ile Asn Lys Asp Gly Tyr Ile Thr Lys Glu Glu Met Leu Asp Ile Met 
145                 150                 155                 160 


Lys Ala Ile Tyr Asp Met Met Gly Lys Cys Thr Tyr Pro Val Leu Lys 
                165                 170                 175     


Glu Asp Ala Pro Arg Gln His Val Glu Thr Phe Phe Gln Lys Met Asp 
            180                 185                 190         


Lys Asn Lys Asp Gly Val Val Thr Ile Asp Glu Phe Ile Glu Ser Cys 
        195                 200                 205             


Gln Lys Asp Glu Asn Ile Met Arg Ser Met Gln Leu Phe Glu Asn Val 
    210                 215                 220                 


Ile 
225 


<210>  5742
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ10__Homo_sapiens__NP_002232

<400>  5742

Met Thr Ser Val Ala Lys Val Tyr Tyr Ser Gln Thr Thr Gln Thr Glu 
1               5                   10                  15      


Ser Arg Pro Leu Met Gly Pro Gly Ile Arg Arg Arg Arg Val Leu Thr 
            20                  25                  30          


Lys Asp Gly Arg Ser Asn Val Arg Met Glu His Ile Ala Asp Lys Arg 
        35                  40                  45              


Phe Leu Tyr Leu Lys Asp Leu Trp Thr Thr Phe Ile Asp Met Gln Trp 
    50                  55                  60                  


Arg Tyr Lys Leu Leu Leu Phe Ser Ala Thr Phe Ala Gly Thr Trp Phe 
65                  70                  75                  80  


Leu Phe Gly Val Val Trp Tyr Leu Val Ala Val Ala His Gly Asp Leu 
                85                  90                  95      


Leu Glu Leu Asp Pro Pro Ala Asn His Thr Pro Cys Val Val Gln Val 
            100                 105                 110         


His Thr Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr 
        115                 120                 125             


Ile Gly Tyr Gly Phe Arg Tyr Ile Ser Glu Glu Cys Pro Leu Ala Ile 
    130                 135                 140                 


Val Leu Leu Ile Ala Gln Leu Val Leu Thr Thr Ile Leu Glu Ile Phe 
145                 150                 155                 160 


Ile Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala 
                165                 170                 175     


Glu Thr Ile Arg Phe Ser Gln His Ala Val Val Ala Ser His Asn Gly 
            180                 185                 190         


Lys Pro Cys Leu Met Ile Arg Val Ala Asn Met Arg Lys Ser Leu Leu 
        195                 200                 205             


Ile Gly Cys Gln Val Thr Gly Lys Leu Leu Gln Thr His Gln Thr Lys 
    210                 215                 220                 


Glu Gly Glu Asn Ile Arg Leu Asn Gln Val Asn Val Thr Phe Gln Val 
225                 230                 235                 240 


Asp Thr Ala Ser Asp Ser Pro Phe Leu Ile Leu Pro Leu Thr Phe Tyr 
                245                 250                 255     


His Val Val Asp Glu Thr Ser Pro Leu Lys Asp Leu Pro Leu Arg Ser 
            260                 265                 270         


Gly Glu Gly Asp Phe Glu Leu Val Leu Ile Leu Ser Gly Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Leu Pro Glu Glu 
    290                 295                 300                 


Ile Leu Trp Gly Tyr Glu Phe Thr Pro Ala Ile Ser Leu Ser Ala Ser 
305                 310                 315                 320 


Gly Lys Tyr Ile Ala Asp Phe Ser Leu Phe Asp Gln Val Val Lys Val 
                325                 330                 335     


Ala Ser Pro Ser Gly Leu Arg Asp Ser Thr Val Arg Tyr Gly Asp Pro 
            340                 345                 350         


Glu Lys Leu Lys Leu Glu Glu Ser Leu Arg Glu Gln Ala Glu Lys Glu 
        355                 360                 365             


Gly Ser Ala Leu Ser Val Arg Ile Ser Asn Val 
    370                 375                 


<210>  5743
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ11__Homo_sapiens__NP_000516

<400>  5743

Met Leu Ser Arg Lys Gly Ile Ile Pro Glu Glu Tyr Val Leu Thr Arg 
1               5                   10                  15      


Leu Ala Glu Asp Pro Ala Lys Pro Arg Tyr Arg Ala Arg Gln Arg Arg 
            20                  25                  30          


Ala Arg Phe Val Ser Lys Lys Gly Asn Cys Asn Val Ala His Lys Asn 
        35                  40                  45              


Ile Arg Glu Gln Gly Arg Phe Leu Gln Asp Val Phe Thr Thr Leu Val 
    50                  55                  60                  


Asp Leu Lys Trp Pro His Thr Leu Leu Ile Phe Thr Met Ser Phe Leu 
65                  70                  75                  80  


Cys Ser Trp Leu Leu Phe Ala Met Ala Trp Trp Leu Ile Ala Phe Ala 
                85                  90                  95      


His Gly Asp Leu Ala Pro Ser Glu Gly Thr Ala Glu Pro Cys Val Thr 
            100                 105                 110         


Ser Ile His Ser Phe Ser Ser Ala Phe Leu Phe Ser Ile Glu Val Gln 
        115                 120                 125             


Val Thr Ile Gly Phe Gly Gly Arg Met Val Thr Glu Glu Cys Pro Leu 
    130                 135                 140                 


Ala Ile Leu Ile Leu Ile Val Gln Asn Ile Val Gly Leu Met Ile Asn 
145                 150                 155                 160 


Ala Ile Met Leu Gly Cys Ile Phe Met Lys Thr Ala Gln Ala His Arg 
                165                 170                 175     


Arg Ala Glu Thr Leu Ile Phe Ser Lys His Ala Val Ile Ala Leu Arg 
            180                 185                 190         


His Gly Arg Leu Cys Phe Met Leu Arg Val Gly Asp Leu Arg Lys Ser 
        195                 200                 205             


Met Ile Ile Ser Ala Thr Ile His Met Gln Val Val Arg Lys Thr Thr 
    210                 215                 220                 


Ser Pro Glu Gly Glu Val Val Pro Leu His Gln Val Asp Ile Pro Met 
225                 230                 235                 240 


Glu Asn Gly Val Gly Gly Asn Ser Ile Phe Leu Val Ala Pro Leu Ile 
                245                 250                 255     


Ile Tyr His Val Ile Asp Ala Asn Ser Pro Leu Tyr Asp Leu Ala Pro 
            260                 265                 270         


Ser Asp Leu His His His Gln Asp Leu Glu Ile Ile Val Ile Leu Glu 
        275                 280                 285             


Gly Val Val Glu Thr Thr Gly Ile Thr Thr Gln Ala Arg Thr Ser Tyr 
    290                 295                 300                 


Leu Ala Asp Glu Ile Leu Trp Gly Gln Arg Phe Val Pro Ile Val Ala 
305                 310                 315                 320 


Glu Glu Asp Gly Arg Tyr Ser Val Asp Tyr Ser Lys Phe Gly Asn Thr 
                325                 330                 335     


Val Lys Val Pro Thr Pro Leu Cys Thr Ala Arg Gln Leu Asp Glu Asp 
            340                 345                 350         


His Ser Leu Leu Glu Ala Leu Thr Leu Ala Ser Ala Arg Gly Pro Leu 
        355                 360                 365             


Arg Lys Arg Ser Val Pro Met Ala Lys Ala Lys Pro Lys Phe Ser Ile 
    370                 375                 380                 


Ser Pro Asp Ser Leu Ser 
385                 390 


<210>  5744
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ12__Homo_sapiens__NP_066292

<400>  5744

Met Thr Ala Ala Ser Arg Ala Asn Pro Tyr Ser Ile Val Ser Ser Glu 
1               5                   10                  15      


Glu Asp Gly Leu His Leu Val Thr Met Ser Gly Ala Asn Gly Phe Gly 
            20                  25                  30          


Asn Gly Lys Val His Thr Arg Arg Arg Cys Arg Asn Arg Phe Val Lys 
        35                  40                  45              


Lys Asn Gly Gln Cys Asn Ile Glu Phe Ala Asn Met Asp Glu Lys Ser 
    50                  55                  60                  


Gln Arg Tyr Leu Ala Asp Met Phe Thr Thr Cys Val Asp Ile Arg Trp 
65                  70                  75                  80  


Arg Tyr Met Leu Leu Ile Phe Ser Leu Ala Phe Leu Ala Ser Trp Leu 
                85                  90                  95      


Leu Phe Gly Ile Ile Phe Trp Val Ile Ala Val Ala His Gly Asp Leu 
            100                 105                 110         


Glu Pro Ala Glu Gly Arg Gly Arg Thr Pro Cys Val Met Gln Val His 
        115                 120                 125             


Gly Phe Met Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Leu Arg Cys Val Thr Glu Glu Cys Pro Val Ala Val Phe 
145                 150                 155                 160 


Met Val Val Ala Gln Ser Ile Val Gly Cys Ile Ile Asp Ser Phe Met 
                165                 170                 175     


Ile Gly Ala Ile Met Ala Lys Met Ala Arg Pro Lys Lys Arg Ala Gln 
            180                 185                 190         


Thr Leu Leu Phe Ser His Asn Ala Val Val Ala Leu Arg Asp Gly Lys 
        195                 200                 205             


Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Ile Val 
    210                 215                 220                 


Glu Ala His Val Arg Ala Gln Leu Ile Lys Pro Arg Val Thr Glu Glu 
225                 230                 235                 240 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asp Val Gly Phe Asp 
                245                 250                 255     


Lys Gly Leu Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Leu His 
            260                 265                 270         


Glu Ile Asp Glu Ala Ser Pro Leu Phe Gly Ile Ser Arg Gln Asp Leu 
        275                 280                 285             


Glu Thr Asp Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu 
    290                 295                 300                 


Ala Thr Ala Met Thr Thr Gln Ala Arg Ser Ser Tyr Leu Ala Asn Glu 
305                 310                 315                 320 


Ile Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe Glu Glu Lys Asn 
                325                 330                 335     


Gln Tyr Lys Ile Asp Tyr Ser His Phe His Lys Thr Tyr Glu Val Pro 
            340                 345                 350         


Ser Thr Pro Arg Cys Ser Ala Lys Asp Leu Val Glu Asn Lys Phe Leu 
        355                 360                 365             


Leu Pro Ser Ala Asn Ser Phe Cys Tyr Glu Asn Glu Leu Ala Phe Leu 
    370                 375                 380                 


Ser Arg Asp Glu Glu Asp Glu Ala Asp Gly Asp Gln Asp Gly Arg Ser 
385                 390                 395                 400 


Arg Asp Gly Leu Ser Pro Gln Ala Arg His Asp Phe Asp Arg Leu Gln 
                405                 410                 415     


Ala Gly Gly Gly Val Leu Glu Gln Arg Pro Tyr Arg Arg Glu Ser Glu 
            420                 425                 430         


Ile 
    


<210>  5745
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ13__Homo_sapiens__NP_001165887

<400>  5745

Met Asp Ser Ser Asn Cys Lys Val Ile Ala Pro Leu Leu Ser Gln Arg 
1               5                   10                  15      


Tyr Arg Arg Met Val Thr Lys Asp Gly His Ser Thr Leu Gln Met Asp 
            20                  25                  30          


Gly Ala Gln Arg Gly Leu Ala Tyr Leu Arg Asp Ala Trp Gly Ile Leu 
        35                  40                  45              


Met Asp Met Arg Trp Arg Trp Met Met Leu Val Phe Ser Ala Ser Phe 
    50                  55                  60                  


Val Val His Trp Leu Val Phe Ala Val Leu Trp Cys Phe Cys Gly Glu 
65                  70                  75                  80  


Asp Cys Pro Ala Lys Lys Ser Ser Phe Phe Asn Ser Leu Tyr 
                85                  90                  


<210>  5746
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ14__Homo_sapiens__NP_037480

<400>  5746

Met Gly Leu Ala Arg Ala Leu Arg Arg Leu Ser Gly Ala Leu Asp Ser 
1               5                   10                  15      


Gly Asp Ser Arg Ala Gly Asp Glu Glu Glu Ala Gly Pro Gly Leu Cys 
            20                  25                  30          


Arg Asn Gly Trp Ala Pro Ala Pro Val Gln Ser Pro Val Gly Arg Arg 
        35                  40                  45              


Arg Gly Arg Phe Val Lys Lys Asp Gly His Cys Asn Val Arg Phe Val 
    50                  55                  60                  


Asn Leu Gly Gly Gln Gly Ala Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Cys Val Asp Val Arg Trp Arg Trp Met Cys Leu Leu Phe Ser Cys Ser 
                85                  90                  95      


Phe Leu Ala Ser Trp Leu Leu Phe Gly Leu Ala Phe Trp Leu Ile Ala 
            100                 105                 110         


Ser Leu His Gly Asp Leu Ala Ala Pro Pro Pro Pro Ala Pro Cys Phe 
        115                 120                 125             


Ser His Val Ala Ser Phe Leu Ala Ala Phe Leu Phe Ala Leu Glu Thr 
    130                 135                 140                 


Gln Thr Ser Ile Gly Tyr Gly Val Arg Ser Val Thr Glu Glu Cys Pro 
145                 150                 155                 160 


Ala Ala Val Ala Ala Val Val Leu Gln Cys Ile Ala Gly Cys Val Leu 
                165                 170                 175     


Asp Ala Phe Val Val Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys 
            180                 185                 190         


Lys Arg Asn Glu Thr Leu Val Phe Ser Glu Asn Ala Val Val Ala Leu 
        195                 200                 205             


Arg Asp His Arg Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Arg 
    210                 215                 220                 


Ser His Leu Val Glu Ala His Val Arg Ala Gln Leu Leu Gln Pro Arg 
225                 230                 235                 240 


Val Thr Pro Glu Gly Glu Tyr Ile Pro Leu Asp His Gln Asp Val Asp 
                245                 250                 255     


Val Gly Phe Asp Gly Gly Thr Asp Arg Ile Phe Leu Val Ser Pro Ile 
            260                 265                 270         


Thr Ile Val His Glu Ile Asp Ser Ala Ser Pro Leu Tyr Glu Leu Gly 
        275                 280                 285             


Arg Ala Glu Leu Ala Arg Ala Asp Phe Glu Leu Val Val Ile Leu Glu 
    290                 295                 300                 


Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr 
305                 310                 315                 320 


Leu Pro Gly Glu Leu Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe 
                325                 330                 335     


Gln Arg Gly Ser Gln Tyr Glu Val Asp Tyr Arg His Phe His Arg Thr 
            340                 345                 350         


Tyr Glu Val Pro Gly Thr Pro Val Cys Ser Ala Lys Glu Leu Asp Glu 
        355                 360                 365             


Arg Ala Glu Gln Ala Ser His Ser Leu Lys Ser Ser Phe Pro Gly Ser 
    370                 375                 380                 


Leu Thr Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Ser Cys Cys Gln 
385                 390                 395                 400 


Glu Glu Asp Glu Asp Asp Glu Thr Glu Glu Gly Asn Gly Val Glu Thr 
                405                 410                 415     


Glu Asp Gly Ala Ala Ser Pro Arg Val Leu Thr Pro Thr Leu Ala Leu 
            420                 425                 430         


Thr Leu Pro Pro 
        435     


<210>  5747
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ15__Homo_sapiens__XP_011527863

<400>  5747

Met Asp Ala Ile His Ile Gly Met Ser Ser Thr Pro Leu Val Lys His 
1               5                   10                  15      


Thr Ala Gly Ala Gly Leu Lys Ala Asn Arg Pro Arg Val Met Ser Lys 
            20                  25                  30          


Ser Gly His Ser Asn Val Arg Ile Asp Lys Val Asp Gly Ile Tyr Leu 
        35                  40                  45              


Leu Tyr Leu Gln Asp Leu Trp Thr Thr Val Ile Asp Met Lys Trp Arg 
    50                  55                  60                  


Tyr Lys Leu Thr Leu Phe Ala Ala Thr Phe Val Met Thr Trp Phe Leu 
65                  70                  75                  80  


Phe Gly Val Ile Tyr Tyr Ala Ile Ala Phe Ile His Gly Asp Leu Glu 
                85                  90                  95      


Pro Gly Glu Pro Ile Ser Asn His Thr Pro Cys Ile Met Lys Val Asp 
            100                 105                 110         


Ser Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr Ile 
        115                 120                 125             


Gly Tyr Gly Val Arg Ser Ile Thr Glu Glu Cys Pro His Ala Ile Phe 
    130                 135                 140                 


Leu Leu Val Ala Gln Leu Val Ile Thr Thr Leu Ile Glu Ile Phe Ile 
145                 150                 155                 160 


Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala Glu 
                165                 170                 175     


Thr Ile Lys Phe Ser His Cys Ala Val Ile Thr Lys Gln Asn Gly Lys 
            180                 185                 190         


Leu Cys Leu Val Ile Gln Val Ala Asn Met Arg Lys Ser Leu Leu Ile 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Leu Leu Gln Thr His Val Thr Lys Glu 
    210                 215                 220                 


Gly Glu Arg Ile Leu Leu Asn Gln Ala Thr Val Lys Phe His Val Asp 
225                 230                 235                 240 


Ser Ser Ser Glu Ser Pro Phe Leu Ile Leu Pro Met Thr Phe Tyr His 
                245                 250                 255     


Val Leu Asp Glu Thr Ser Pro Leu Arg Asp Leu Thr Pro Gln Asn Leu 
            260                 265                 270         


Lys Glu Lys Glu Phe Glu Leu Val Val Leu Leu Asn Ala Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Val Cys Gln Ser Arg Thr Ser Tyr Ile Pro Glu Glu 
    290                 295                 300                 


Ile Tyr Trp Gly Phe Glu Phe Val Pro Val Val Ser Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Lys Tyr Val Ala Asp Phe Ser Gln Phe Glu Gln Ile Arg Lys Ser 
                325                 330                 335     


Pro Asp Cys Thr Phe Tyr Cys Ala Asp Ser Glu Lys Gln Gln Leu Glu 
            340                 345                 350         


Glu Lys Tyr Arg Gln Glu Asp Gln Arg Glu Arg Glu Leu Arg Thr Leu 
        355                 360                 365             


Leu Leu Gln Gln Ser Asn Val 
    370                 375 


<210>  5748
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ16__Homo_sapiens__NP_001278551

<400>  5748

Met Leu Lys Met Val Leu Thr Glu Asn Pro Asn Gln Glu Ile Ala Thr 
1               5                   10                  15      


Ser Leu Glu Phe Leu Leu Leu Gln Asn Ser Pro Gly Ser Leu Arg Ala 
            20                  25                  30          


Gln Gln Arg Met Ser Tyr Tyr Gly Ser Ser Tyr His Ile Ile Asn Ala 
        35                  40                  45              


Asp Ala Lys Tyr Pro Gly Tyr Pro Pro Glu His Ile Ile Ala Glu Lys 
    50                  55                  60                  


Arg Arg Ala Arg Arg Arg Leu Leu His Lys Asp Gly Ser Cys Asn Val 
65                  70                  75                  80  


Tyr Phe Lys His Ile Phe Gly Glu Trp Gly Ser Tyr Val Val Asp Ile 
                85                  90                  95      


Phe Thr Thr Leu Val Asp Thr Lys Trp Arg His Met Phe Val Ile Phe 
            100                 105                 110         


Ser Leu Ser Tyr Ile Leu Ser Trp Leu Ile Phe Gly Ser Val Phe Trp 
        115                 120                 125             


Leu Ile Ala Phe His His Gly Asp Leu Leu Asn Asp Pro Asp Ile Thr 
    130                 135                 140                 


Pro Cys Val Asp Asn Val His Ser Phe Thr Gly Ala Phe Leu Phe Ser 
145                 150                 155                 160 


Leu Glu Thr Gln Thr Thr Ile Gly Tyr Gly Tyr Arg Cys Val Thr Glu 
                165                 170                 175     


Glu Cys Ser Val Ala Val Leu Met Val Ile Leu Gln Ser Ile Leu Ser 
            180                 185                 190         


Cys Ile Ile Asn Thr Phe Ile Ile Gly Ala Ala Leu Ala Lys Met Ala 
        195                 200                 205             


Thr Ala Arg Lys Arg Ala Gln Thr Ile Arg Phe Ser Tyr Phe Ala Leu 
    210                 215                 220                 


Ile Gly Met Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Ile Gly Asp 
225                 230                 235                 240 


Phe Arg Pro Asn His Val Val Glu Gly Thr Val Arg Ala Gln Leu Leu 
                245                 250                 255     


Arg Tyr Thr Glu Asp Ser Glu Gly Arg Met Thr Met Ala Phe Lys Asp 
            260                 265                 270         


Leu Lys Leu Val Asn Asp Gln Ile Ile Leu Val Thr Pro Val Thr Ile 
        275                 280                 285             


Val His Glu Ile Asp His Glu Ser Pro Leu Tyr Ala Leu Asp Arg Lys 
    290                 295                 300                 


Ala Val Ala Lys Asp Asn Phe Glu Ile Leu Val Thr Phe Ile Tyr Thr 
305                 310                 315                 320 


Gly Asp Ser Thr Gly Thr Ser His Gln Ser Arg Ser Ser Tyr Val Pro 
                325                 330                 335     


Arg Glu Ile Leu Trp Gly His Arg Phe Asn Asp Val Leu Glu Val Lys 
            340                 345                 350         


Arg Lys Tyr Tyr Lys Val Asn Cys Leu Gln Phe Glu Gly Ser Val Glu 
        355                 360                 365             


Val Tyr Ala Pro Phe Cys Ser Ala Lys Gln Leu Asp Trp Lys Asp Gln 
    370                 375                 380                 


Gln Leu His Ile Glu Lys Ala Pro Pro Val Arg Glu Ser Cys Thr Ser 
385                 390                 395                 400 


Asp Thr Lys Ala Arg Arg Arg Ser Phe Ser Ala Val Ala Ile Val Ser 
                405                 410                 415     


Ser Cys Glu Asn Pro Glu Glu Thr Thr Thr Ser Ala Thr His Glu Tyr 
            420                 425                 430         


Arg Glu Thr Pro Tyr Gln Lys Ala Leu Leu Thr Leu Asn Arg Ile Ser 
        435                 440                 445             


Val Glu Ser Gln Met 
    450             


<210>  5749
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ18__Homo_sapiens__NP_001181887

<400>  5749

Met Thr Ala Ala Ser Arg Ala Asn Pro Tyr Ser Ile Val Ser Leu Glu 
1               5                   10                  15      


Glu Asp Gly Leu His Leu Val Thr Met Ser Gly Ala Asn Gly Phe Gly 
            20                  25                  30          


Asn Gly Lys Val His Thr Arg Arg Arg Cys Arg Asn Arg Phe Val Lys 
        35                  40                  45              


Lys Asn Gly Gln Cys Asn Ile Ala Phe Ala Asn Met Asp Glu Lys Ser 
    50                  55                  60                  


Gln Arg Tyr Leu Ala Asp Met Phe Thr Thr Cys Val Asp Ile Arg Trp 
65                  70                  75                  80  


Arg Tyr Met Leu Leu Ile Phe Ser Leu Ala Phe Leu Ala Ser Trp Leu 
                85                  90                  95      


Leu Phe Gly Val Ile Phe Trp Val Ile Ala Val Ala His Gly Asp Leu 
            100                 105                 110         


Glu Pro Ala Glu Gly His Gly Arg Thr Pro Cys Val Met Gln Val His 
        115                 120                 125             


Gly Phe Met Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Leu Arg Cys Val Thr Glu Glu Cys Leu Val Ala Val Phe 
145                 150                 155                 160 


Met Val Val Ala Gln Ser Ile Val Gly Cys Ile Ile Asp Ser Phe Met 
                165                 170                 175     


Ile Gly Ala Ile Met Ala Lys Met Ala Arg Pro Lys Lys Arg Ala Gln 
            180                 185                 190         


Thr Leu Leu Phe Ser His Asn Ala Val Val Ala Leu Arg Asp Gly Lys 
        195                 200                 205             


Leu Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Ile Val 
    210                 215                 220                 


Glu Ala His Val Arg Ala Gln Leu Ile Lys Pro Arg Val Thr Glu Glu 
225                 230                 235                 240 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asp Val Gly Phe Asp 
                245                 250                 255     


Lys Gly Leu Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Leu His 
            260                 265                 270         


Glu Ile Asp Glu Ala Ser Pro Leu Phe Gly Ile Ser Arg Gln Asp Leu 
        275                 280                 285             


Glu Thr Asp Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu 
    290                 295                 300                 


Ala Thr Ala Met Thr Thr Gln Ala Arg Ser Ser Tyr Leu Ala Asn Glu 
305                 310                 315                 320 


Ile Leu Trp Gly His Arg Phe Glu Pro Val Leu Phe Glu Glu Lys Asn 
                325                 330                 335     


Gln Tyr Lys Ile Asp Tyr Ser His Phe His Lys Thr Tyr Glu Val Pro 
            340                 345                 350         


Ser Thr Pro Arg Cys Ser Ala Lys Asp Leu Val Glu Asn Lys Phe Leu 
        355                 360                 365             


Leu Pro Ser Ala Asn Ser Phe Cys Tyr Glu Asn Glu Leu Ala Phe Leu 
    370                 375                 380                 


Ser Arg Asp Glu Glu Asp Glu Ala Asp Gly Asp Gln Asp Gly Arg Ser 
385                 390                 395                 400 


Arg Asp Gly Leu Ser Pro Gln Ala Arg His Asp Phe Asp Arg Leu Gln 
                405                 410                 415     


Ala Gly Gly Gly Val Leu Glu Gln Arg Pro Tyr Arg Arg Gly Ser Glu 
            420                 425                 430         


Ile 
    


<210>  5750
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ1__Homo_sapiens__NP_000211

<400>  5750

Met Asn Ala Ser Ser Arg Asn Val Phe Asp Thr Leu Ile Arg Val Leu 
1               5                   10                  15      


Thr Glu Ser Met Phe Lys His Leu Arg Lys Trp Val Val Thr Arg Phe 
            20                  25                  30          


Phe Gly His Ser Arg Gln Arg Ala Arg Leu Val Ser Lys Asp Gly Arg 
        35                  40                  45              


Cys Asn Ile Glu Phe Gly Asn Val Glu Ala Gln Ser Arg Phe Ile Phe 
    50                  55                  60                  


Phe Val Asp Ile Trp Thr Thr Val Leu Asp Leu Lys Trp Arg Tyr Lys 
65                  70                  75                  80  


Met Thr Ile Phe Ile Thr Ala Phe Leu Gly Ser Trp Phe Phe Phe Gly 
                85                  90                  95      


Leu Leu Trp Tyr Ala Val Ala Tyr Ile His Lys Asp Leu Pro Glu Phe 
            100                 105                 110         


His Pro Ser Ala Asn His Thr Pro Cys Val Glu Asn Ile Asn Gly Leu 
        115                 120                 125             


Thr Ser Ala Phe Leu Phe Ser Leu Glu Thr Gln Val Thr Ile Gly Tyr 
    130                 135                 140                 


Gly Phe Arg Cys Val Thr Glu Gln Cys Ala Thr Ala Ile Phe Leu Leu 
145                 150                 155                 160 


Ile Phe Gln Ser Ile Leu Gly Val Ile Ile Asn Ser Phe Met Cys Gly 
                165                 170                 175     


Ala Ile Leu Ala Lys Ile Ser Arg Pro Lys Lys Arg Ala Lys Thr Ile 
            180                 185                 190         


Thr Phe Ser Lys Asn Ala Val Ile Ser Lys Arg Gly Gly Lys Leu Cys 
        195                 200                 205             


Leu Leu Ile Arg Val Ala Asn Leu Arg Lys Ser Leu Leu Ile Gly Ser 
    210                 215                 220                 


His Ile Tyr Gly Lys Leu Leu Lys Thr Thr Val Thr Pro Glu Gly Glu 
225                 230                 235                 240 


Thr Ile Ile Leu Asp Gln Ile Asn Ile Asn Phe Val Val Asp Ala Gly 
                245                 250                 255     


Asn Glu Asn Leu Phe Phe Ile Ser Pro Leu Thr Ile Tyr His Val Ile 
            260                 265                 270         


Asp His Asn Ser Pro Phe Phe His Met Ala Ala Glu Thr Leu Leu Gln 
        275                 280                 285             


Gln Asp Phe Glu Leu Val Val Phe Leu Asp Gly Thr Val Glu Ser Thr 
    290                 295                 300                 


Ser Ala Thr Cys Gln Val Arg Thr Ser Tyr Val Pro Glu Glu Val Leu 
305                 310                 315                 320 


Trp Gly Tyr Arg Phe Ala Pro Ile Val Ser Lys Thr Lys Glu Gly Lys 
                325                 330                 335     


Tyr Arg Val Asp Phe His Asn Phe Ser Lys Thr Val Glu Val Glu Thr 
            340                 345                 350         


Pro His Cys Ala Met Cys Leu Tyr Asn Glu Lys Asp Val Arg Ala Arg 
        355                 360                 365             


Met Lys Arg Gly Tyr Asp Asn Pro Asn Phe Ile Leu Ser Glu Val Asn 
    370                 375                 380                 


Glu Thr Asp Asp Thr Lys Met 
385                 390     


<210>  5751
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ2__Homo_sapiens__XP_011523081

<400>  5751

Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              


Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  


Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  


Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp 
                85                  90                  95      


Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         


Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser 
        115                 120                 125             


Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 


Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 


Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     


Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         


Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             


Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 


Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     


Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         


Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp 
        275                 280                 285             


Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 


Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 


Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr 
                325                 330                 335     


Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         


Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             


Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 


Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr 
385                 390                 395                 400 


Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu 
                405                 410                 415     


Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425         


<210>  5752
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ3__Homo_sapiens__NP_001247437

<400>  5752

Met Ser Ala Leu Arg Arg Lys Phe Gly Asp Asp Tyr Gln Val Val Thr 
1               5                   10                  15      


Thr Ser Ser Ser Gly Ser Gly Leu Gln Pro Gln Gly Pro Gly Gln Asp 
            20                  25                  30          


Pro Gln Gln Gln Leu Val Pro Lys Lys Lys Arg Gln Arg Phe Val Asp 
        35                  40                  45              


Lys Asn Gly Arg Cys Asn Val Gln His Gly Asn Leu Gly Ser Glu Thr 
    50                  55                  60                  


Ser Arg Tyr Leu Ser Asp Leu Phe Thr Thr Leu Val Asp Leu Lys Trp 
65                  70                  75                  80  


Arg Trp Asn Leu Phe Ile Phe Ile Leu Thr Tyr Thr Val Ala Trp Leu 
                85                  90                  95      


Phe Met Ala Ser Met Trp Trp Val Ile Ala Tyr Thr Arg Gly Asp Leu 
            100                 105                 110         


Asn Lys Ala His Val Gly Asn Tyr Thr Pro Cys Val Ala Asn Val Tyr 
        115                 120                 125             


Asn Phe Pro Ser Ala Phe Leu Phe Phe Ile Glu Thr Glu Ala Thr Ile 
    130                 135                 140                 


Gly Tyr Gly Tyr Arg Tyr Ile Thr Asp Lys Cys Pro Glu Gly Ile Ile 
145                 150                 155                 160 


Leu Phe Leu Phe Gln Ser Ile Leu Gly Ser Ile Val Asp Ala Phe Leu 
                165                 170                 175     


Ile Gly Cys Met Phe Ile Lys Met Ser Gln Pro Lys Lys Arg Ala Glu 
            180                 185                 190         


Thr Leu Met Phe Ser Glu His Ala Val Ile Ser Met Arg Asp Gly Lys 
        195                 200                 205             


Leu Thr Leu Met Phe Arg Val Gly Asn Leu Arg Asn Ser His Met Val 
    210                 215                 220                 


Ser Ala Gln Ile Arg Cys Lys Leu Leu Lys Gly 
225                 230                 235 


<210>  5753
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ4__Homo_sapiens__NP_690607

<400>  5753

Met His Gly His Ser Arg Asn Gly Gln Ala His Val Pro Arg Arg Lys 
1               5                   10                  15      


Arg Arg Asn Arg Phe Val Lys Lys Asn Gly Gln Cys Asn Val Tyr Phe 
            20                  25                  30          


Ala Asn Leu Ser Asn Lys Ser Gln Arg Tyr Met Ala Asp Ile Phe Thr 
        35                  40                  45              


Thr Cys Val Asp Thr Arg Trp Arg Tyr Met Leu Met Ile Phe Ser Ala 
    50                  55                  60                  


Ala Phe Leu Val Ser Trp Leu Phe Phe Gly Leu Leu Phe Trp Cys Ile 
65                  70                  75                  80  


Ala Phe Phe His Gly Asp Leu Glu Ala Ser Pro Gly Val Pro Ala Ala 
                85                  90                  95      


Gly Gly Pro Ala Ala Gly Gly Gly Gly Ala Ala Pro Val Ala Pro Lys 
            100                 105                 110         


Pro Cys Ile Met His Val Asn Gly Phe Leu Gly Ala Phe Leu Phe Ser 
        115                 120                 125             


Val Glu Thr Gln Thr Thr Ile Gly Tyr Gly Phe Arg Cys Val Thr Glu 
    130                 135                 140                 


Glu Cys Pro Leu Ala Val Ile Ala Val Val Val Gln Ser Ile Val Gly 
145                 150                 155                 160 


Cys Val Ile Asp Ser Phe Met Ile Gly Thr Ile Met Ala Lys Met Ala 
                165                 170                 175     


Arg Pro Lys Lys Arg Ala Gln Thr Leu Leu Phe Ser His His Ala Val 
            180                 185                 190         


Ile Ser Val Arg Asp Gly Lys Leu Cys Leu Met Trp Arg Val Gly Asn 
        195                 200                 205             


Leu Arg Lys Ser His Ile Val Glu Ala His Val Arg Ala Gln Leu Ile 
    210                 215                 220                 


Lys Pro Tyr Met Thr Gln Glu Gly Glu Tyr Leu Pro Leu Asp Gln Arg 
225                 230                 235                 240 


Asp Leu Asn Val Gly Tyr Asp Ile Gly Leu Asp Arg Ile Phe Leu Val 
                245                 250                 255     


Ser Pro Ile Ile Ile Val His Glu Ile Asp Glu Asp Ser Pro Leu Tyr 
            260                 265                 270         


Gly Met Gly Lys Glu Glu Leu Glu Ser Glu Asp Phe Glu Ile Val Val 
        275                 280                 285             


Ile Leu Glu Gly Met Val Glu Ala Thr Ala Met Thr Thr Gln Ala Arg 
    290                 295                 300                 


Ser Ser Tyr Leu Ala Ser Glu Ile Leu Trp Gly His Arg Phe Glu Pro 
305                 310                 315                 320 


Val Val Phe Glu Glu Lys Ser His Tyr Lys Val Asp Tyr Ser Arg Phe 
                325                 330                 335     


His Lys Thr Tyr Glu Val Ala Gly Thr Pro Cys Cys Ser Ala Arg Glu 
            340                 345                 350         


Leu Gln Glu Ser Lys Ile Thr Val Leu Pro Ala Pro Pro Pro Pro Pro 
        355                 360                 365             


Ser Ala Phe Cys Tyr Glu Asn Glu Leu Ala Leu Met Ser Gln Glu Glu 
    370                 375                 380                 


Glu Glu Met Glu Glu Glu Ala Ala Ala Ala Ala Ala Val Ala Ala Gly 
385                 390                 395                 400 


Leu Gly Leu Glu Ala Gly Ser Lys Glu Glu Ala Gly Ile Ile Arg Met 
                405                 410                 415     


Leu Glu Phe Gly Ser His Leu Asp Leu Glu Arg Met Gln Ala Ser Leu 
            420                 425                 430         


Pro Leu Asp Asn Ile Ser Tyr Arg Arg Glu Ser Ala Ile 
        435                 440                 445 


<210>  5754
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ5__Homo_sapiens__XP_011541112

<400>  5754

Met Ala Gly Asp Ser Arg Asn Ala Met Asn Gln Asp Met Glu Ile Gly 
1               5                   10                  15      


Val Thr Pro Trp Asp Pro Lys Lys Ile Pro Lys Gln Ala Arg Asp Tyr 
            20                  25                  30          


Val Pro Ile Ala Thr Asp Arg Thr Arg Leu Leu Ala Glu Gly Lys Lys 
        35                  40                  45              


Pro Arg Gln Arg Tyr Met Glu Lys Ser Gly Lys Cys Asn Val His His 
    50                  55                  60                  


Gly Asn Val Gln Glu Thr Tyr Arg Tyr Leu Ser Asp Leu Phe Thr Thr 
65                  70                  75                  80  


Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Val Phe Thr Met Val 
                85                  90                  95      


Tyr Thr Val Thr Trp Leu Phe Phe Gly Phe Ile Trp Trp Leu Ile Ala 
            100                 105                 110         


Tyr Ile Arg Gly Asp Leu Asp His Val Gly Asp Gln Glu Trp Ile Pro 
        115                 120                 125             


Cys Val Glu Asn Leu Ser Gly Phe Val Ser Ala Phe Leu Phe Ser Ile 
    130                 135                 140                 


Glu Thr Glu Thr Thr Ile Gly Tyr Gly Phe Arg Val Ile Thr Glu Lys 
145                 150                 155                 160 


Cys Pro Glu Gly Ile Ile Leu Leu Leu Val Gln Ala Ile Leu Gly Ser 
                165                 170                 175     


Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys Ile Ser Gln 
            180                 185                 190         


Pro Lys Lys Arg Ala Glu Thr Leu Met Phe Ser Asn Asn Ala Val Ile 
        195                 200                 205             


Ser Met Arg Asp Glu Lys Leu Cys Leu Met Phe Arg Val Gly Asp Leu 
    210                 215                 220                 


Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys Leu Ile Lys 
225                 230                 235                 240 


Ser Arg Gln Thr Lys Glu Gly Glu Phe Ile Pro Leu Asn Gln Thr Asp 
                245                 250                 255     


Ile Asn Val Gly Phe Asp Thr Gly Asp Asp Arg Leu Phe Leu Val Ser 
            260                 265                 270         


Pro Leu Ile Ile Ser His Glu Ile Asn Gln Lys Ser Pro Phe Trp Glu 
        275                 280                 285             


Met Ser Gln Ala Gln Leu His Gln Glu Glu Phe Glu Val Val Val Ile 
    290                 295                 300                 


Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln Ala Arg Ser 
305                 310                 315                 320 


Ser Tyr Met Asp Thr Glu Val Leu Trp Gly His Arg Phe Thr Pro Val 
                325                 330                 335     


Leu Thr Leu Glu Lys Gly Phe Tyr Glu Val Asp Tyr Asn Thr Phe His 
            340                 345                 350         


Asp Thr Tyr Glu Thr Asn Thr Pro Ser Cys Cys Ala Lys Glu Leu Ala 
        355                 360                 365             


Glu Met Lys Arg Glu Gly Arg Leu Leu Gln Tyr Leu Pro Ser Pro Pro 
    370                 375                 380                 


Leu Leu Gly Gly Cys Ala Glu Ala Gly Leu Asp Ala Glu Ala Glu Gln 
385                 390                 395                 400 


Asn Glu Glu Asp Glu Pro Lys Gly Leu Gly Gly Ser Arg Glu Ala Arg 
                405                 410                 415     


Gly Ser Val 
            


<210>  5755
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ6__Homo_sapiens__NP_002231

<400>  5755

Met Ala Lys Leu Thr Glu Ser Met Thr Asn Val Leu Glu Gly Asp Ser 
1               5                   10                  15      


Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro Lys Leu 
            20                  25                  30          


Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg Asp Arg 
        35                  40                  45              


Thr Lys Arg Lys Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys Cys Asn 
    50                  55                  60                  


Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Ile 
65                  70                  75                  80  


Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Ile Phe 
                85                  90                  95      


Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile Trp Trp 
            100                 105                 110         


Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp Pro Ser 
        115                 120                 125             


Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala Phe Leu 
    130                 135                 140                 


Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg Val Ile 
145                 150                 155                 160 


Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln Ser Val 
                165                 170                 175     


Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys 
            180                 185                 190         


Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser Thr His 
        195                 200                 205             


Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe Arg Val 
    210                 215                 220                 


Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys 
225                 230                 235                 240 


Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro Leu Asn 
                245                 250                 255     


Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg Leu Phe 
            260                 265                 270         


Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln Ser Pro 
        275                 280                 285             


Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu Glu Ile 
    290                 295                 300                 


Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln 
305                 310                 315                 320 


Ala Arg Ser Ser Tyr Ile Thr Ser Glu Ile Leu Trp Gly Tyr Arg Phe 
                325                 330                 335     


Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Asn 
            340                 345                 350         


Ser Phe His Glu Thr Tyr Glu Thr Ser Thr Pro Ser Leu Ser Ala Lys 
        355                 360                 365             


Glu Leu Ala Glu Leu Ala Ser Arg Ala Glu Leu Pro Leu Ser Trp Ser 
    370                 375                 380                 


Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu Glu Glu 
385                 390                 395                 400 


Glu Lys Asn Leu Glu Glu Gln Thr Glu Arg Asn Gly Asp Val Ala Asn 
                405                 410                 415     


Leu Glu Asn Glu Ser Lys Val 
            420             


<210>  5756
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ8__Homo_sapiens__XP_005253415

<400>  5756

Met Leu Ala Arg Lys Ser Ile Ile Pro Glu Glu Tyr Val Leu Ala Arg 
1               5                   10                  15      


Ile Ala Ala Glu Asn Leu Arg Lys Pro Arg Ile Arg Asp Arg Leu Pro 
            20                  25                  30          


Lys Ala Arg Phe Ile Ala Lys Ser Gly Ala Cys Asn Leu Ala His Lys 
        35                  40                  45              


Asn Ile Arg Glu Gln Gly Arg Phe Leu Gln Asp Ile Phe Thr Thr Leu 
    50                  55                  60                  


Val Asp Leu Lys Trp Arg His Thr Leu Val Ile Phe Thr Met Ser Phe 
65                  70                  75                  80  


Leu Cys Ser Trp Leu Leu Phe Ala Ile Met Trp Trp Leu Val Ala Phe 
                85                  90                  95      


Ala His Gly Asp Ile Tyr Ala Tyr Met Glu Lys Ser Gly Met Glu Lys 
            100                 105                 110         


Ser Gly Leu Glu Ser Thr Val Cys Val Thr Asn Val Arg Ser Phe Thr 
        115                 120                 125             


Ser Ala Phe Leu Phe Ser Ile Glu Val Gln Val Thr Ile Gly Phe Gly 
    130                 135                 140                 


Gly Arg Met Met Thr Glu Glu Cys Pro Leu Ala Ile Thr Val Leu Ile 
145                 150                 155                 160 


Leu Gln Asn Ile Val Gly Leu Ile Ile Asn Ala Val Met Leu Gly Cys 
                165                 170                 175     


Ile Phe Met Lys Thr Ala Gln Ala His Arg Arg Ala Glu Thr Leu Ile 
            180                 185                 190         


Phe Ser Arg His Ala Val Ile Ala Val Arg Asn Gly Lys Leu Cys Phe 
        195                 200                 205             


Met Phe Arg Val Gly Asp Leu Arg Lys Ser Met Ile Ile Ser Ala Ser 
    210                 215                 220                 


Val Arg Ile Gln Val Val Lys Lys Thr Thr Thr Pro Glu Gly Glu Val 
225                 230                 235                 240 


Val Pro Ile His Gln Leu Asp Ile Pro Val Asp Asn Pro Ile Glu Ser 
                245                 250                 255     


Asn Asn Ile Phe Leu Val Ala Pro Leu Ile Ile Cys His Val Ile Asp 
            260                 265                 270         


Lys Arg Ser Pro Leu Tyr Asp Ile Ser Ala Thr Asp Leu Ala Asn Gln 
        275                 280                 285             


Asp Leu Glu Val Ile Val Ile Leu Glu Gly Val Val Glu Thr Thr Gly 
    290                 295                 300                 


Ile Thr Thr Gln Ala Arg Thr Ser Tyr Ile Ala Glu Glu Ile Gln Trp 
305                 310                 315                 320 


Gly His Arg Phe Val Ser Ile Val Thr Glu Glu Glu Gly Val Tyr Ser 
                325                 330                 335     


Val Asp Tyr Ser Lys Phe Gly Asn Thr Val Lys Val Ala Ala Pro Arg 
            340                 345                 350         


Cys Ser Ala Arg Glu Leu Asp Glu Lys Pro Ser Ile Leu Ile Gln Thr 
        355                 360                 365             


Leu Gln Lys Ser Glu Leu Ser His Gln Asn Ser Leu Arg Lys Arg Asn 
    370                 375                 380                 


Ser Met Arg Arg Asn Asn Ser Met Arg Arg Asn Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Asn Asn Ser Ser Leu Met Val Pro Lys Val Gln Phe Met Thr Pro Glu 
                405                 410                 415     


Gly Asn Gln Asn Thr Ser Glu Ser 
            420                 


<210>  5757
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNJ9__Homo_sapiens__XP_006711368

<400>  5757

Met Arg Ser Arg Leu Glu Glu Leu Lys Phe Leu Glu Gly Arg Trp Arg 
1               5                   10                  15      


Asn Gln Val Leu Asp Leu Glu Ile Glu Pro Leu Gln Asp Pro Arg Arg 
            20                  25                  30          


Arg Leu Gly Ala Gln Arg Arg Ala Ala Gly Gly Ser Ser Ser Gly Pro 
        35                  40                  45              


Arg Arg Thr Pro Gly Ala Arg Ser Ala Arg Pro Asp Ala Ala Ala Met 
    50                  55                  60                  


Ala Gln Glu Asn Ala Ala Phe Ser Pro Gly Gln Glu Glu Pro Pro Arg 
65                  70                  75                  80  


Arg Arg Gly Arg Gln Arg Tyr Val Glu Lys Asp Gly Arg Cys Asn Val 
                85                  90                  95      


Gln Gln Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Leu Phe 
            100                 105                 110         


Thr Thr Leu Val Asp Leu Gln Trp Arg Leu Ser Leu Leu Phe Phe Val 
        115                 120                 125             


Leu Ala Tyr Ala Leu Thr Trp Leu Phe Phe Gly Ala Ile Trp Trp Leu 
    130                 135                 140                 


Ile Ala Tyr Gly Arg Gly Asp Leu Glu His Leu Glu Asp Thr Ala Trp 
145                 150                 155                 160 


Thr Pro Cys Val Asn Asn Leu Asn Gly Phe Val Ala Ala Phe Leu Phe 
                165                 170                 175     


Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly His Arg Val Ile Thr 
            180                 185                 190         


Asp Gln Cys Pro Glu Gly Ile Val Leu Leu Leu Leu Gln Ala Ile Leu 
        195                 200                 205             


Gly Ser Met Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys Ile 
    210                 215                 220                 


Ser Gln Pro Asn Lys Arg Ala Ala Thr Leu Val Phe Ser Ser His Ala 
225                 230                 235                 240 


Val Val Ser Leu Arg Asp Gly Arg Leu Cys Leu Met Phe Arg Val Gly 
                245                 250                 255     


Asp Leu Arg Ser Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys Leu 
            260                 265                 270         


Ile Arg Ser Arg Gln Thr Leu Glu Gly Glu Phe Ile Pro Leu His Gln 
        275                 280                 285             


Thr Asp Leu Ser Val Gly Phe Asp Thr Gly Asp Asp Arg Leu Phe Leu 
    290                 295                 300                 


Val Ser Pro Leu Val Ile Ser His Glu Ile Asp Ala Ala Ser Pro Phe 
305                 310                 315                 320 


Trp Glu Ala Ser Arg Arg Ala Leu Glu Arg Asp Asp Phe Glu Ile Val 
                325                 330                 335     


Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln Ala 
            340                 345                 350         


Arg Ser Ser Tyr Leu Val Asp Glu Val Leu Trp Gly His Arg Phe Thr 
        355                 360                 365             


Ser Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Ala Ser 
    370                 375                 380                 


Phe His Glu Thr Phe Glu Val Pro Thr Pro Ser Cys Ser Ala Arg Glu 
385                 390                 395                 400 


Leu Ala Glu Ala Ala Ala Arg Leu Asp Ala His Leu Tyr Trp Ser Ile 
                405                 410                 415     


Pro Ser Arg Leu Asp Glu Lys Val Glu Glu Glu Gly Ala Gly Glu Gly 
            420                 425                 430         


Ala Gly Gly Glu Ala Gly Ala Asp Lys Glu Gln Asn Gly Cys Leu Pro 
        435                 440                 445             


Pro Pro Glu Ser Glu Ser Lys Val 
    450                 455     


<210>  5758
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK10__Homo_sapiens__NP_066984

<400>  5758

Met Phe Phe Leu Tyr Thr Asp Phe Phe Leu Ser Leu Val Ala Val Pro 
1               5                   10                  15      


Ala Ala Ala Pro Val Cys Gln Pro Lys Ser Ala Thr Asn Gly Gln Pro 
            20                  25                  30          


Pro Ala Pro Ala Pro Thr Pro Thr Pro Arg Leu Ser Ile Ser Ser Arg 
        35                  40                  45              


Ala Thr Val Val Ala Arg Met Glu Gly Thr Ser Gln Gly Gly Leu Gln 
    50                  55                  60                  


Thr Val Met Lys Trp Lys Thr Val Val Ala Ile Phe Val Val Val Val 
65                  70                  75                  80  


Val Tyr Leu Val Thr Gly Gly Leu Val Phe Arg Ala Leu Glu Gln Pro 
                85                  90                  95      


Phe Glu Ser Ser Gln Lys Asn Thr Ile Ala Leu Glu Lys Ala Glu Phe 
            100                 105                 110         


Leu Arg Asp His Val Cys Val Ser Pro Gln Glu Leu Glu Thr Leu Ile 
        115                 120                 125             


Gln His Ala Leu Asp Ala Asp Asn Ala Gly Val Ser Pro Ile Gly Asn 
    130                 135                 140                 


Ser Ser Asn Asn Ser Ser His Trp Asp Leu Gly Ser Ala Phe Phe Phe 
145                 150                 155                 160 


Ala Gly Thr Val Ile Thr Thr Ile Gly Tyr Gly Asn Ile Ala Pro Ser 
                165                 170                 175     


Thr Glu Gly Gly Lys Ile Phe Cys Ile Leu Tyr Ala Ile Phe Gly Ile 
            180                 185                 190         


Pro Leu Phe Gly Phe Leu Leu Ala Gly Ile Gly Asp Gln Leu Gly Thr 
        195                 200                 205             


Ile Phe Gly Lys Ser Ile Ala Arg Val Glu Lys Val Phe Arg Lys Lys 
    210                 215                 220                 


Gln Val Ser Gln Thr Lys Ile Arg Val Ile Ser Thr Ile Leu Phe Ile 
225                 230                 235                 240 


Leu Ala Gly Cys Ile Val Phe Val Thr Ile Pro Ala Val Ile Phe Lys 
                245                 250                 255     


Tyr Ile Glu Gly Trp Thr Ala Leu Glu Ser Ile Tyr Phe Val Val Val 
            260                 265                 270         


Thr Leu Thr Thr Val Gly Phe Gly Asp Phe Val Ala Gly Gly Asn Ala 
        275                 280                 285             


Gly Ile Asn Tyr Arg Glu Trp Tyr Lys Pro Leu Val Trp Phe Trp Ile 
    290                 295                 300                 


Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu Ser Met Ile Gly Asp 
305                 310                 315                 320 


Trp Leu Arg Val Leu Ser Lys Lys Thr Lys Glu Glu Val Gly Glu Ile 
                325                 330                 335     


Lys Ala His Ala Ala Glu Trp Lys Ala Asn Val Thr Ala Glu Phe Arg 
            340                 345                 350         


Glu Thr Arg Arg Arg Leu Ser Val Glu Ile His Asp Lys Leu Gln Arg 
        355                 360                 365             


Ala Ala Thr Ile Arg Ser Met Glu Arg Arg Arg Leu Gly Leu Asp Gln 
    370                 375                 380                 


Arg Ala His Ser Leu Asp Met Leu Ser Pro Glu Lys Arg Ser Val Phe 
385                 390                 395                 400 


Ala Ala Leu Asp Thr Gly Arg Phe Lys Ala Ser Ser Gln Glu Ser Ile 
                405                 410                 415     


Asn Asn Arg Pro Asn Asn Leu Arg Leu Lys Gly Pro Glu Gln Leu Asn 
            420                 425                 430         


Lys His Gly Gln Gly Ala Ser Glu Asp Asn Ile Ile Asn Lys Phe Gly 
        435                 440                 445             


Ser Thr Ser Arg Leu Thr Lys Arg Lys Asn Lys Asp Leu Lys Lys Thr 
    450                 455                 460                 


Leu Pro Glu Asp Val Gln Lys Ile Tyr Lys Thr Phe Arg Asn Tyr Ser 
465                 470                 475                 480 


Leu Asp Glu Glu Lys Lys Glu Glu Glu Thr Glu Lys Met Cys Asn Ser 
                485                 490                 495     


Asp Asn Ser Ser Thr Ala Met Leu Thr Asp Cys Ile Gln Gln His Ala 
            500                 505                 510         


Glu Leu Glu Asn Gly Met Ile Pro Thr Asp Thr Lys Asp Arg Glu Pro 
        515                 520                 525             


Glu Asn Asn Ser Leu Leu Glu Asp Arg Asn 
    530                 535             


<210>  5759
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK12__Homo_sapiens__NP_071338

<400>  5759

Met Ser Ser Arg Ser Pro Arg Pro Pro Pro Arg Arg Ser Arg Arg Arg 
1               5                   10                  15      


Leu Pro Arg Pro Ser Cys Cys Cys Cys Cys Cys Arg Arg Ser His Leu 
            20                  25                  30          


Asn Glu Asp Thr Gly Arg Phe Val Leu Leu Ala Ala Leu Ile Gly Leu 
        35                  40                  45              


Tyr Leu Val Ala Gly Ala Thr Val Phe Ser Ala Leu Glu Ser Pro Gly 
    50                  55                  60                  


Glu Ala Glu Ala Arg Ala Arg Trp Gly Ala Thr Leu Arg Asn Phe Ser 
65                  70                  75                  80  


Ala Ala His Gly Val Ala Glu Pro Glu Leu Arg Ala Phe Leu Arg His 
                85                  90                  95      


Tyr Glu Ala Ala Leu Ala Ala Gly Val Arg Ala Asp Ala Leu Arg Pro 
            100                 105                 110         


Arg Trp Asp Phe Pro Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser 
        115                 120                 125             


Thr Ile Gly Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ala 
    130                 135                 140                 


Phe Leu Ile Ala Tyr Gly Leu Phe Gly Cys Ala Gly Thr Ile Leu Phe 
145                 150                 155                 160 


Phe Asn Leu Phe Leu Glu Arg Ile Ile Ser Leu Leu Ala Phe Ile Met 
                165                 170                 175     


Arg Ala Cys Arg Glu Arg Gln Leu Arg Arg Ser Gly Leu Leu Pro Ala 
            180                 185                 190         


Thr Phe Arg Arg Gly Ser Ala Leu Ser Glu Ala Asp Ser Leu Ala Gly 
        195                 200                 205             


Trp Lys Pro Ser Val Tyr His Val Leu Leu Ile Leu Gly Leu Phe Ala 
    210                 215                 220                 


Val Leu Leu Ser Cys Cys Ala Ser Ala Met Tyr Thr Ser Val Glu Gly 
225                 230                 235                 240 


Trp Asp Tyr Val Asp Ser Leu Tyr Phe Cys Phe Val Thr Phe Ser Thr 
                245                 250                 255     


Ile Gly Phe Gly Asp Leu Val Ser Ser Gln His Ala Ala Tyr Arg Asn 
            260                 265                 270         


Gln Gly Leu Tyr Arg Leu Gly Asn Phe Leu Phe Ile Leu Leu Gly Val 
        275                 280                 285             


Cys Cys Ile Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln 
    290                 295                 300                 


Val Leu Asn Trp Met Leu Arg Lys Leu Ser Cys Arg Cys Cys Ala Arg 
305                 310                 315                 320 


Cys Cys Pro Ala Pro Gly Ala Pro Leu Ala Arg Arg Asn Ala Ile Thr 
                325                 330                 335     


Pro Gly Ser Arg Leu Arg Arg Arg Leu Ala Ala Leu Gly Ala Asp Pro 
            340                 345                 350         


Ala Ala Arg Asp Ser Asp Ala Glu Gly Arg Arg Leu Ser Gly Glu Leu 
        355                 360                 365             


Ile Ser Met Arg Asp Leu Thr Ala Ser Asn Lys Val Ser Leu Ala Leu 
    370                 375                 380                 


Leu Gln Lys Gln Leu Ser Glu Thr Ala Asn Gly Tyr Pro Arg Ser Val 
385                 390                 395                 400 


Cys Val Asn Thr Arg Gln Asn Gly Phe Ser Gly Gly Val Gly Ala Leu 
                405                 410                 415     


Gly Ile Met Asn Asn Arg Leu Ala Glu Thr Ser Ala Ser Arg 
            420                 425                 430 


<210>  5760
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK16__Homo_sapiens__NP_001128577

<400>  5760

Met Pro Ser Ala Gly Leu Cys Ser Cys Trp Gly Gly Arg Val Leu Pro 
1               5                   10                  15      


Leu Leu Leu Ala Tyr Val Cys Tyr Leu Leu Leu Gly Ala Thr Ile Phe 
            20                  25                  30          


Gln Leu Leu Glu Arg Gln Ala Glu Ala Gln Ser Arg Asp Gln Phe Gln 
        35                  40                  45              


Leu Glu Lys Leu Arg Phe Leu Glu Asn Tyr Thr Cys Leu Asp Gln Trp 
    50                  55                  60                  


Ala Met Glu Gln Phe Val Gln Val Ile Met Glu Ala Trp Val Lys Gly 
65                  70                  75                  80  


Val Asn Pro Lys Gly Asn Ser Thr Asn Pro Ser Asn Trp Asp Phe Gly 
                85                  90                  95      


Ser Ser Phe Phe Phe Ala Gly Thr Val Val Thr Thr Ile Gly Tyr Gly 
            100                 105                 110         


Asn Leu Ala Pro Ser Thr Glu Ala Gly Gln Val Phe Cys Val Phe Tyr 
        115                 120                 125             


Ala Leu Leu Gly Ile Pro Leu Asn Val Ile Phe Leu Asn His Leu Gly 
    130                 135                 140                 


Thr Gly Leu Arg Ala His Leu Ala Ala Ile Glu Arg Trp Glu Asp Arg 
145                 150                 155                 160 


Pro Arg Arg Ser Gln Val Leu Gln Val Leu Gly Leu Ala Leu Phe Leu 
                165                 170                 175     


Thr Leu Gly Thr Leu Val Ile Leu Ile Phe Pro Pro Met Val Phe Ser 
            180                 185                 190         


His Val Glu Gly Trp Ser Phe Ser Glu Gly Phe Tyr Phe Ala Phe Ile 
        195                 200                 205             


Thr Leu Ser Thr Ile Gly Phe Gly Asp Tyr Val Val Gly His Pro Leu 
    210                 215                 220                 


Asn Phe Ile Thr Pro Ser Gly Leu Leu Pro Ser Gln Glu Pro Phe Gln 
225                 230                 235                 240 


Thr Pro His Gly Lys Pro Glu Ser Gln Gln Ile Pro Gly Ser Phe Gln 
                245                 250                 255     


Lys Val Ser Ser Met Asn Val Trp Pro Leu Ser Gly Met His Ser Pro 
            260                 265                 270         


Gly Leu Ala Phe Pro Leu Pro Asp Cys Asn Ile Pro Asp Gln Glu Arg 
        275                 280                 285             


Phe Arg Pro Leu His Pro Gly Ala Trp Lys Phe Trp Pro Leu Pro Leu 
    290                 295                 300                 


Pro Ser Ser Asn Ser Lys Trp Ala Pro Met Trp Leu Gly Ser Ser Ala 
305                 310                 315                 320 


Gln Val 
        


<210>  5761
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK17__Homo_sapiens__NP_001128583

<400>  5761

Met Tyr Arg Pro Arg Ala Arg Ala Ala Pro Glu Gly Arg Val Arg Gly 
1               5                   10                  15      


Cys Ala Val Pro Ser Thr Val Leu Leu Leu Leu Ala Tyr Leu Ala Tyr 
            20                  25                  30          


Leu Ala Leu Gly Thr Gly Val Phe Trp Thr Leu Glu Gly Arg Ala Ala 
        35                  40                  45              


Gln Asp Ser Ser Arg Ser Phe Gln Arg Asp Lys Trp Glu Leu Leu Gln 
    50                  55                  60                  


Asn Phe Thr Cys Leu Asp Arg Pro Ala Leu Asp Ser Leu Ile Arg Asp 
65                  70                  75                  80  


Val Val Gln Ala Tyr Lys Asn Gly Ala Ser Leu Leu Ser Asn Thr Thr 
                85                  90                  95      


Ser Met Gly Arg Trp Glu Leu Val Gly Ser Phe Phe Phe Ser Val Ser 
            100                 105                 110         


Thr Ile Thr Thr Ile Gly Tyr Gly Asn Leu Ser Pro Asn Thr Met Ala 
        115                 120                 125             


Ala Arg Leu Phe Cys Ile Phe Phe Ala Leu Val Gly Ile Pro Leu Asn 
    130                 135                 140                 


Leu Val Val Leu Asn Arg Leu Gly His Leu Met Gln Gln Gly Val Asn 
145                 150                 155                 160 


His Trp Ala Ser Arg Leu Gly Gly Thr Trp Gln Asp Pro Asp Lys Ala 
                165                 170                 175     


Arg Trp Leu Ala Gly Ser Gly Ala Leu Leu Ser Gly Leu Leu Leu Phe 
            180                 185                 190         


Leu Leu Leu Pro Pro Leu Leu Phe Ser His Met Glu Gly Trp Ser Tyr 
        195                 200                 205             


Thr Glu Gly Phe Tyr Phe Ala Phe Ile Thr Leu Ser Thr Val Gly Phe 
    210                 215                 220                 


Gly Asp Tyr Val Ile Ala Ser Cys Leu Ile Ser Asp Thr Arg Lys Pro 
225                 230                 235                 240 


Asn Arg Asp Trp Gln Thr Leu Glu Arg Thr Ser Lys Ser Ser Gly Gly 
                245                 250                 255     


Leu Leu Lys Tyr Arg Phe Leu Ala Gly His Gly Gly Ser His Leu 
            260                 265                 270     


<210>  5762
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK18__Homo_sapiens__NP_862823

<400>  5762

Met Glu Val Ser Gly His Pro Gln Ala Arg Arg Cys Cys Pro Glu Ala 
1               5                   10                  15      


Leu Gly Lys Leu Phe Pro Gly Leu Cys Phe Leu Cys Phe Leu Val Thr 
            20                  25                  30          


Tyr Ala Leu Val Gly Ala Val Val Phe Ser Ala Ile Glu Asp Gly Gln 
        35                  40                  45              


Val Leu Val Ala Ala Asp Asp Gly Glu Phe Glu Lys Phe Leu Glu Glu 
    50                  55                  60                  


Leu Cys Arg Ile Leu Asn Cys Ser Glu Thr Val Val Glu Asp Arg Lys 
65                  70                  75                  80  


Gln Asp Leu Gln Gly His Leu Gln Lys Val Lys Pro Gln Trp Phe Asn 
                85                  90                  95      


Arg Thr Thr His Trp Ser Phe Leu Ser Ser Leu Phe Phe Cys Cys Thr 
            100                 105                 110         


Val Phe Ser Thr Val Gly Tyr Gly Tyr Ile Tyr Pro Val Thr Arg Leu 
        115                 120                 125             


Gly Lys Tyr Leu Cys Met Leu Tyr Ala Leu Phe Gly Ile Pro Leu Met 
    130                 135                 140                 


Phe Leu Val Leu Thr Asp Thr Gly Asp Ile Leu Ala Thr Ile Leu Ser 
145                 150                 155                 160 


Thr Ser Tyr Asn Arg Phe Arg Lys Phe Pro Phe Phe Thr Arg Pro Leu 
                165                 170                 175     


Leu Ser Lys Trp Cys Pro Lys Ser Leu Phe Lys Lys Lys Pro Asp Pro 
            180                 185                 190         


Lys Pro Ala Asp Glu Ala Val Pro Gln Ile Ile Ile Ser Ala Glu Glu 
        195                 200                 205             


Leu Pro Gly Pro Lys Leu Gly Thr Cys Pro Ser Arg Pro Ser Cys Ser 
    210                 215                 220                 


Met Glu Leu Phe Glu Arg Ser His Ala Leu Glu Lys Gln Asn Thr Leu 
225                 230                 235                 240 


Gln Leu Pro Pro Gln Ala Met Glu Arg Ser Asn Ser Cys Pro Glu Leu 
                245                 250                 255     


Val Leu Gly Arg Leu Ser Tyr Ser Ile Ile Ser Asn Leu Asp Glu Val 
            260                 265                 270         


Gly Gln Gln Val Glu Arg Leu Asp Ile Pro Leu Pro Ile Ile Ala Leu 
        275                 280                 285             


Ile Val Phe Ala Tyr Ile Ser Cys Ala Ala Ala Ile Leu Pro Phe Trp 
    290                 295                 300                 


Glu Thr Gln Leu Asp Phe Glu Asn Ala Phe Tyr Phe Cys Phe Val Thr 
305                 310                 315                 320 


Leu Thr Thr Ile Gly Phe Gly Asp Thr Val Leu Glu His Pro Asn Phe 
                325                 330                 335     


Phe Leu Phe Phe Ser Ile Tyr Ile Ile Val Gly Met Glu Ile Val Phe 
            340                 345                 350         


Ile Ala Phe Lys Leu Val Gln Asn Arg Leu Ile Asp Ile Tyr Lys Asn 
        355                 360                 365             


Val Met Leu Phe Phe Ala Lys Gly Lys Phe Tyr His Leu Val Lys Lys 
    370                 375                 380                 


<210>  5763
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK1__Homo_sapiens__NP_002236

<400>  5763

Met Leu Gln Ser Leu Ala Gly Ser Ser Cys Val Arg Leu Val Glu Arg 
1               5                   10                  15      


His Arg Ser Ala Trp Cys Phe Gly Phe Leu Val Leu Gly Tyr Leu Leu 
            20                  25                  30          


Tyr Leu Val Phe Gly Ala Val Val Phe Ser Ser Val Glu Leu Pro Tyr 
        35                  40                  45              


Glu Asp Leu Leu Arg Gln Glu Leu Arg Lys Leu Lys Arg Arg Phe Leu 
    50                  55                  60                  


Glu Glu His Glu Cys Leu Ser Glu Gln Gln Leu Glu Gln Phe Leu Gly 
65                  70                  75                  80  


Arg Val Leu Glu Ala Ser Asn Tyr Gly Val Ser Val Leu Ser Asn Ala 
                85                  90                  95      


Ser Gly Asn Trp Asn Trp Asp Phe Thr Ser Ala Leu Phe Phe Ala Ser 
            100                 105                 110         


Thr Val Leu Ser Thr Thr Gly Tyr Gly His Thr Val Pro Leu Ser Asp 
        115                 120                 125             


Gly Gly Lys Ala Phe Cys Ile Ile Tyr Ser Val Ile Gly Ile Pro Phe 
    130                 135                 140                 


Thr Leu Leu Phe Leu Thr Ala Val Val Gln Arg Ile Thr Val His Val 
145                 150                 155                 160 


Thr Arg Arg Pro Val Leu Tyr Phe His Ile Arg Trp Gly Phe Ser Lys 
                165                 170                 175     


Gln Val Val Ala Ile Val His Ala Val Leu Leu Gly Phe Val Thr Val 
            180                 185                 190         


Ser Cys Phe Phe Phe Ile Pro Ala Ala Val Phe Ser Val Leu Glu Asp 
        195                 200                 205             


Asp Trp Asn Phe Leu Glu Ser Phe Tyr Phe Cys Phe Ile Ser Leu Ser 
    210                 215                 220                 


Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu Gly Tyr Asn Gln Lys 
225                 230                 235                 240 


Phe Arg Glu Leu Tyr Lys Ile Gly Ile Thr Cys Tyr Leu Leu Leu Gly 
                245                 250                 255     


Leu Ile Ala Met Leu Val Val Leu Glu Thr Phe Cys Glu Leu His Glu 
            260                 265                 270         


Leu Lys Lys Phe Arg Lys Met Phe Tyr Val Lys Lys Asp Lys Asp Glu 
        275                 280                 285             


Asp Gln Val His Ile Ile Glu His Asp Gln Leu Ser Phe Ser Ser Ile 
    290                 295                 300                 


Thr Asp Gln Ala Ala Gly Met Lys Glu Asp Gln Lys Gln Asn Glu Pro 
305                 310                 315                 320 


Phe Val Ala Thr Gln Ser Ser Ala Cys Val Asp Gly Pro Ala Asn His 
                325                 330                 335     


<210>  5764
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK2__Homo_sapiens__NP_001017424

<400>  5764

Met Met Asn Pro Arg Ala Lys Arg Asp Phe Tyr Leu Ala Ala Pro Asp 
1               5                   10                  15      


Leu Leu Asp Pro Lys Ser Ala Ala Gln Asn Ser Lys Pro Arg Leu Ser 
            20                  25                  30          


Phe Ser Thr Lys Pro Thr Val Leu Ala Ser Arg Val Glu Ser Asp Thr 
        35                  40                  45              


Thr Ile Asn Val Met Lys Trp Lys Thr Val Ser Thr Ile Phe Leu Val 
    50                  55                  60                  


Val Val Leu Tyr Leu Ile Ile Gly Ala Thr Val Phe Lys Ala Leu Glu 
65                  70                  75                  80  


Gln Pro His Glu Ile Ser Gln Arg Thr Thr Ile Val Ile Gln Lys Gln 
                85                  90                  95      


Thr Phe Ile Ser Gln His Ser Cys Val Asn Ser Thr Glu Leu Asp Glu 
            100                 105                 110         


Leu Ile Gln Gln Ile Val Ala Ala Ile Asn Ala Gly Ile Ile Pro Leu 
        115                 120                 125             


Gly Asn Thr Ser Asn Gln Ile Ser His Trp Asp Leu Gly Ser Ser Phe 
    130                 135                 140                 


Phe Phe Ala Gly Thr Val Ile Thr Thr Ile Gly Phe Gly Asn Ile Ser 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gly Lys Ile Phe Cys Ile Ile Tyr Ala Leu Leu 
                165                 170                 175     


Gly Ile Pro Leu Phe Gly Phe Leu Leu Ala Gly Val Gly Asp Gln Leu 
            180                 185                 190         


Gly Thr Ile Phe Gly Lys Gly Ile Ala Lys Val Glu Asp Thr Phe Ile 
        195                 200                 205             


Lys Trp Asn Val Ser Gln Thr Lys Ile Arg Ile Ile Ser Thr Ile Ile 
    210                 215                 220                 


Phe Ile Leu Phe Gly Cys Val Leu Phe Val Ala Leu Pro Ala Ile Ile 
225                 230                 235                 240 


Phe Lys His Ile Glu Gly Trp Ser Ala Leu Asp Ala Ile Tyr Phe Val 
                245                 250                 255     


Val Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Gly Gly 
            260                 265                 270         


Ser Asp Ile Glu Tyr Leu Asp Phe Tyr Lys Pro Val Val Trp Phe Trp 
        275                 280                 285             


Ile Leu Val Gly Leu Ala Tyr Phe Ala Ala Val Leu Ser Met Ile Gly 
    290                 295                 300                 


Asp Trp Leu Arg Val Ile Ser Lys Lys Thr Lys Glu Glu Val Gly Glu 
305                 310                 315                 320 


Phe Arg Ala His Ala Ala Glu Trp Thr Ala Asn Val Thr Ala Glu Phe 
                325                 330                 335     


Lys Glu Thr Arg Arg Arg Leu Ser Val Glu Ile Tyr Asp Lys Phe Gln 
            340                 345                 350         


Arg Ala Thr Ser Ile Lys Arg Lys Leu Ser Ala Glu Leu Ala Gly Asn 
        355                 360                 365             


His Asn Gln Glu Leu Thr Pro Cys Arg Arg Thr Leu Ser Val Asn His 
    370                 375                 380                 


Leu Thr Ser Glu Arg Asp Val Leu Pro Pro Leu Leu Lys Thr Glu Ser 
385                 390                 395                 400 


Ile Tyr Leu Asn Gly Leu Thr Pro His Cys Ala Gly Glu Glu Ile Ala 
                405                 410                 415     


Val Ile Glu Asn Ile Lys 
            420         


<210>  5765
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK3__Homo_sapiens__NP_002237

<400>  5765

Met Lys Arg Gln Asn Val Arg Thr Leu Ala Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Pro Glu Leu Ile Glu Arg Gln Arg Leu Glu Leu Arg Gln Gln Glu Leu 
        35                  40                  45              


Arg Ala Arg Tyr Asn Leu Ser Gln Gly Gly Tyr Glu Glu Leu Glu Arg 
    50                  55                  60                  


Val Val Leu Arg Leu Lys Pro His Lys Ala Gly Val Gln Trp Arg Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Ser Thr Asp Gly Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Ile Asn Thr Leu Val Arg Tyr Leu Leu His Arg Ala Lys 
    130                 135                 140                 


Lys Gly Leu Gly Met Arg Arg Ala Asp Val Ser Met Ala Asn Met Val 
145                 150                 155                 160 


Leu Ile Gly Phe Phe Ser Cys Ile Ser Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser His Tyr Glu His Trp Thr Phe Phe Gln Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Lys Asp Gln Ala Leu Gln Thr Gln Pro Gln Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Val Tyr Ile Leu Thr Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Met Thr Met Asn Ala Glu Asp Glu Lys Arg 
                245                 250                 255     


Asp Ala Glu His Arg Ala Leu Leu Thr Arg Asn Gly Gln Ala Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Ser Ala His Thr Thr Asp Thr Ala Ser Ser Thr 
        275                 280                 285             


Ala Ala Ala Gly Gly Gly Gly Phe Arg Asn Val Tyr Ala Glu Val Leu 
    290                 295                 300                 


His Phe Gln Ser Met Cys Ser Cys Leu Trp Tyr Lys Ser Arg Glu Lys 
305                 310                 315                 320 


Leu Gln Tyr Ser Ile Pro Met Ile Ile Pro Arg Asp Leu Ser Thr Ser 
                325                 330                 335     


Asp Thr Cys Val Glu Gln Ser His Ser Ser Pro Gly Gly Gly Gly Arg 
            340                 345                 350         


Tyr Ser Asp Thr Pro Ser Arg Arg Cys Leu Cys Ser Gly Ala Pro Arg 
        355                 360                 365             


Ser Ala Ile Ser Ser Val Ser Thr Gly Leu His Ser Leu Ser Thr Phe 
    370                 375                 380                 


Arg Gly Leu Met Lys Arg Arg Ser Ser Val 
385                 390                 


<210>  5766
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK5__Homo_sapiens__NP_003731

<400>  5766

Met Val Asp Arg Gly Pro Leu Leu Thr Ser Ala Ile Ile Phe Tyr Leu 
1               5                   10                  15      


Ala Ile Gly Ala Ala Ile Phe Glu Val Leu Glu Glu Pro His Trp Lys 
            20                  25                  30          


Glu Ala Lys Lys Asn Tyr Tyr Thr Gln Lys Leu His Leu Leu Lys Glu 
        35                  40                  45              


Phe Pro Cys Leu Gly Gln Glu Gly Leu Asp Lys Ile Leu Glu Val Val 
    50                  55                  60                  


Ser Asp Ala Ala Gly Gln Gly Val Ala Ile Thr Gly Asn Gln Thr Phe 
65                  70                  75                  80  


Asn Asn Trp Asn Trp Pro Asn Ala Met Ile Phe Ala Ala Thr Val Ile 
                85                  90                  95      


Thr Thr Ile Gly Tyr Gly Asn Val Ala Pro Lys Thr Pro Ala Gly Arg 
            100                 105                 110         


Leu Phe Cys Val Phe Tyr Gly Leu Phe Gly Val Pro Leu Cys Leu Thr 
        115                 120                 125             


Trp Ile Ser Ala Leu Gly Lys Phe Phe Gly Gly Arg Ala Lys Arg Leu 
    130                 135                 140                 


Gly Gln Phe Leu Thr Lys Arg Gly Val Ser Leu Arg Lys Ala Gln Ile 
145                 150                 155                 160 


Thr Cys Thr Val Ile Phe Ile Val Trp Gly Val Leu Val His Leu Val 
                165                 170                 175     


Ile Pro Pro Phe Val Phe Met Val Thr Glu Gly Trp Asn Tyr Ile Glu 
            180                 185                 190         


Gly Leu Tyr Tyr Ser Phe Ile Thr Ile Ser Thr Ile Gly Phe Gly Asp 
        195                 200                 205             


Phe Val Ala Gly Val Asn Pro Ser Ala Asn Tyr His Ala Leu Tyr Arg 
    210                 215                 220                 


Tyr Phe Val Glu Leu Trp Ile Tyr Leu Gly Leu Ala Trp Leu Ser Leu 
225                 230                 235                 240 


Phe Val Asn Trp Lys Val Ser Met Phe Val Glu Val His Lys Ala Ile 
                245                 250                 255     


Lys Lys Arg Arg Arg Arg Arg Lys Glu Ser Phe Glu Ser Ser Pro His 
            260                 265                 270         


Ser Arg Lys Ala Leu Gln Val Lys Gly Ser Thr Ala Ser Lys Asp Val 
        275                 280                 285             


Asn Ile Phe Ser Phe Leu Ser Lys Lys Glu Glu Thr Tyr Asn Asp Leu 
    290                 295                 300                 


Ile Lys Gln Ile Gly Lys Lys Ala Met Lys Thr Ser Gly Gly Gly Glu 
305                 310                 315                 320 


Thr Gly Pro Gly Pro Gly Leu Gly Pro Gln Gly Gly Gly Leu Pro Ala 
                325                 330                 335     


Leu Pro Pro Ser Leu Val Pro Leu Val Val Tyr Ser Lys Asn Arg Val 
            340                 345                 350         


Pro Thr Leu Glu Glu Val Ser Gln Thr Leu Arg Ser Lys Gly His Val 
        355                 360                 365             


Ser Arg Ser Pro Asp Glu Glu Ala Val Ala Arg Ala Pro Glu Asp Ser 
    370                 375                 380                 


Ser Pro Ala Pro Glu Val Phe Met Asn Gln Leu Asp Arg Ile Ser Glu 
385                 390                 395                 400 


Glu Cys Glu Pro Trp Asp Ala Gln Asp Tyr His Pro Leu Ile Phe Gln 
                405                 410                 415     


Asp Ala Ser Ile Thr Phe Val Asn Thr Glu Ala Gly Leu Ser Asp Glu 
            420                 425                 430         


Glu Thr Ser Lys Ser Ser Leu Glu Asp Asn Leu Ala Gly Glu Glu Ser 
        435                 440                 445             


Pro Gln Gln Gly Ala Glu Ala Lys Ala Pro Leu Asn Met Gly Glu Phe 
    450                 455                 460                 


Pro Ser Ser Ser Glu Ser Thr Phe Thr Ser Thr Glu Ser Glu Leu Ser 
465                 470                 475                 480 


Val Pro Tyr Glu Gln Leu Met Asn Glu Tyr Asn Lys Ala Asn Ser Pro 
                485                 490                 495     


Lys Gly Thr 
            


<210>  5767
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK6__Homo_sapiens__NP_004814

<400>  5767

Met Arg Arg Gly Ala Leu Leu Ala Gly Ala Leu Ala Ala Tyr Ala Ala 
1               5                   10                  15      


Tyr Leu Val Leu Gly Ala Leu Leu Val Ala Arg Leu Glu Gly Pro His 
            20                  25                  30          


Glu Ala Arg Leu Arg Ala Glu Leu Glu Thr Leu Arg Ala Gln Leu Leu 
        35                  40                  45              


Gln Arg Ser Pro Cys Val Ala Ala Pro Ala Leu Asp Ala Phe Val Glu 
    50                  55                  60                  


Arg Val Leu Ala Ala Gly Arg Leu Gly Arg Val Val Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Gly Ser Ala Asn Ala Ser Asp Pro Ala Trp Asp Phe Ala Ser Ala 
                85                  90                  95      


Leu Phe Phe Ala Ser Thr Leu Ile Thr Thr Val Gly Tyr Gly Tyr Thr 
            100                 105                 110         


Thr Pro Leu Thr Asp Ala Gly Lys Ala Phe Ser Ile Ala Phe Ala Leu 
        115                 120                 125             


Leu Gly Val Pro Thr Thr Met Leu Leu Leu Thr Ala Ser Ala Gln Arg 
    130                 135                 140                 


Leu Ser Leu Leu Leu Thr His Val Pro Leu Ser Trp Leu Ser Met Arg 
145                 150                 155                 160 


Trp Gly Trp Asp Pro Arg Arg Ala Ala Cys Trp His Leu Val Ala Leu 
                165                 170                 175     


Leu Gly Val Val Val Thr Val Cys Phe Leu Val Pro Ala Val Ile Phe 
            180                 185                 190         


Ala His Leu Glu Glu Ala Trp Ser Phe Leu Asp Ala Phe Tyr Phe Cys 
        195                 200                 205             


Phe Ile Ser Leu Ser Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu 
    210                 215                 220                 


Ala Pro Gly Gln Pro Tyr Arg Ala Leu Tyr Lys Val Leu Val Thr Val 
225                 230                 235                 240 


Tyr Leu Phe Leu Gly Leu Val Ala Met Val Leu Val Leu Gln Thr Phe 
                245                 250                 255     


Arg His Val Ser Asp Leu His Gly Leu Thr Glu Leu Ile Leu Leu Pro 
            260                 265                 270         


Pro Pro Cys Pro Ala Ser Phe Asn Ala Asp Glu Asp Asp Arg Val Asp 
        275                 280                 285             


Ile Leu Gly Pro Gln Pro Glu Ser His Gln Gln Leu Ser Ala Ser Ser 
    290                 295                 300                 


His Thr Asp Tyr Ala Ser Ile Pro Arg 
305                 310             


<210>  5768
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNK9__Homo_sapiens__XP_011515404

<400>  5768

Met Lys Arg Gln Asn Val Arg Thr Leu Ser Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Asp 
            20                  25                  30          


His Glu Met Arg Glu Glu Glu Lys Leu Lys Ala Glu Glu Ile Arg Ile 
        35                  40                  45              


Lys Gly Lys Tyr Asn Ile Ser Ser Glu Asp Tyr Arg Gln Leu Glu Leu 
    50                  55                  60                  


Val Ile Leu Gln Ser Glu Pro His Arg Ala Gly Val Gln Trp Lys Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Gly Thr Asp Ala Gly Lys Ala Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Val Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Met Asn Thr Phe Val Arg Tyr Leu Leu Lys Arg Ile Lys 
    130                 135                 140                 


Lys Cys Cys Gly Met Arg Asn Thr Asp Val Ser Met Glu Asn Met Val 
145                 150                 155                 160 


Thr Val Gly Phe Phe Ser Cys Met Gly Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser Gln Cys Glu Glu Trp Ser Phe Phe His Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Thr Lys Gly Ala Leu Gln Lys Lys Pro Leu Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Met Tyr Ile Leu Val Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Leu Thr Met Asn Ser Glu Asp Glu Arg Arg 
                245                 250                 255     


Asp Ala Glu Glu Arg Ala Ser Leu Ala Gly Asn Arg Asn Ser Met Val 
            260                 265                 270         


Ile His Ile Pro Glu Glu Pro Arg Pro Ser Arg Pro Arg Tyr Lys Ala 
        275                 280                 285             


Asp Val Pro Asp Leu Gln Ser Val Cys Ser Cys Thr Cys Tyr Arg Ser 
    290                 295                 300                 


Gln Asp Tyr Gly Gly Arg Ser Val Ala Pro Gln Asn Ser Phe Ser Ala 
305                 310                 315                 320 


Lys Leu Ala Pro His Tyr Phe His Ser Ile Ser Tyr Lys Ile Glu Glu 
                325                 330                 335     


Ile Ser Pro Ser Thr Leu Lys Asn Ser Leu Phe Pro Ser Pro Ile Ser 
            340                 345                 350         


Ser Ile Ser Pro Gly Leu His Ser Phe Thr Asp His Gln Arg Leu Met 
        355                 360                 365             


Lys Arg Arg Lys Ser Val 
    370                 


<210>  5769
<211>  1236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNMA1__Homo_sapiens__NP_001154824

<400>  5769

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Pro Lys Met Ser Ile Tyr Lys 
    690                 695                 700                 


Arg Met Arg Arg Ala Cys Cys Phe Asp Cys Gly Arg Ser Glu Arg Asp 
705                 710                 715                 720 


Cys Ser Cys Met Ser Gly Arg Val Arg Gly Asn Val Asp Thr Leu Glu 
                725                 730                 735     


Arg Ala Phe Pro Leu Ser Ser Val Ser Val Asn Asp Cys Ser Thr Ser 
            740                 745                 750         


Phe Arg Ala Phe Glu Asp Glu Gln Pro Ser Thr Leu Ser Pro Lys Lys 
        755                 760                 765             


Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro Asn Thr Ser Pro Lys 
    770                 775                 780                 


Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly Asn Asp Gln Ile Asp 
785                 790                 795                 800 


Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser Thr Gly Met Phe His 
                805                 810                 815     


Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile Leu Thr Arg Ser Glu 
            820                 825                 830         


Ala Ala Met Thr Val Leu Ser Gly His Val Val Val Cys Ile Phe Gly 
        835                 840                 845             


Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val Met Pro Leu 
    850                 855                 860                 


Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile Val Phe Val 
865                 870                 875                 880 


Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu His Asn Phe 
                885                 890                 895     


Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu 
            900                 905                 910         


Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile Leu Ser Ala 
        915                 920                 925             


Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile 
    930                 935                 940                 


Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp Ser Ile Gly 
945                 950                 955                 960 


Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly Met Asp Arg 
                965                 970                 975     


Ser Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg Gln Pro Ser 
            980                 985                 990         


Ile Thr Thr Gly Val Asn Ile Pro  Ile Ile Thr Glu Leu  Val Asn Asp 
        995                 1000                 1005             


Thr Asn  Val Gln Phe Leu Asp  Gln Asp Asp Asp Asp  Asp Pro Asp 
    1010                 1015                 1020             


Thr Glu  Leu Tyr Leu Thr Gln  Pro Phe Ala Cys Gly  Thr Ala Phe 
    1025                 1030                 1035             


Ala Val  Ser Val Leu Asp Ser  Leu Met Ser Ala Thr  Tyr Phe Asn 
    1040                 1045                 1050             


Asp Asn  Ile Leu Thr Leu Ile  Arg Thr Leu Val Thr  Gly Gly Ala 
    1055                 1060                 1065             


Thr Pro  Glu Leu Glu Ala Leu  Ile Ala Glu Glu Asn  Ala Leu Arg 
    1070                 1075                 1080             


Gly Gly  Tyr Ser Thr Pro Gln  Thr Leu Ala Asn Arg  Asp Arg Cys 
    1085                 1090                 1095             


Arg Val  Ala Gln Leu Ala Leu  Leu Asp Gly Pro Phe  Ala Asp Leu 
    1100                 1105                 1110             


Gly Asp  Gly Gly Cys Tyr Gly  Asp Leu Phe Cys Lys  Ala Leu Lys 
    1115                 1120                 1125             


Thr Tyr  Asn Met Leu Cys Phe  Gly Ile Tyr Arg Leu  Arg Asp Ala 
    1130                 1135                 1140             


His Leu  Ser Thr Pro Ser Gln  Cys Thr Lys Arg Tyr  Val Ile Thr 
    1145                 1150                 1155             


Asn Pro  Pro Tyr Glu Phe Glu  Leu Val Pro Thr Asp  Leu Ile Phe 
    1160                 1165                 1170             


Cys Leu  Met Gln Phe Asp His  Asn Ala Gly Gln Ser  Arg Ala Ser 
    1175                 1180                 1185             


Leu Ser  His Ser Ser His Ser  Ser Gln Ser Ser Ser  Lys Lys Ser 
    1190                 1195                 1200             


Ser Ser  Val His Ser Ile Pro  Ser Thr Ala Asn Arg  Gln Asn Arg 
    1205                 1210                 1215             


Pro Lys  Ser Arg Glu Ser Arg  Asp Lys Gln Lys Tyr  Val Gln Glu 
    1220                 1225                 1230             


Glu Arg  Leu 
    1235     


<210>  5770
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNMB1__Homo_sapiens__NP_004128

<400>  5770

Met Val Lys Lys Leu Val Met Ala Gln Lys Arg Gly Glu Thr Arg Ala 
1               5                   10                  15      


Leu Cys Leu Gly Val Thr Met Val Val Cys Ala Val Ile Thr Tyr Tyr 
            20                  25                  30          


Ile Leu Val Thr Thr Val Leu Pro Leu Tyr Gln Lys Ser Val Trp Thr 
        35                  40                  45              


Gln Glu Ser Lys Cys His Leu Ile Glu Thr Asn Ile Arg Asp Gln Glu 
    50                  55                  60                  


Glu Leu Lys Gly Lys Lys Val Pro Gln Tyr Pro Cys Leu Trp Val Asn 
65                  70                  75                  80  


Val Ser Ala Ala Gly Arg Trp Ala Val Leu Tyr His Thr Glu Asp Thr 
                85                  90                  95      


Arg Asp Gln Asn Gln Gln Cys Ser Tyr Ile Pro Gly Ser Val Asp Asn 
            100                 105                 110         


Tyr Gln Thr Ala Arg Ala Asp Val Glu Lys Val Arg Ala Lys Phe Gln 
        115                 120                 125             


Glu Gln Gln Val Phe Tyr Cys Phe Ser Ala Pro Arg Gly Asn Glu Thr 
    130                 135                 140                 


Ser Val Leu Phe Gln Arg Leu Tyr Gly Pro Gln Ala Leu Leu Phe Ser 
145                 150                 155                 160 


Leu Phe Trp Pro Thr Phe Leu Leu Thr Gly Gly Leu Leu Ile Ile Ala 
                165                 170                 175     


Met Val Lys Ser Asn Gln Tyr Leu Ser Ile Leu Ala Ala Gln Lys 
            180                 185                 190     


<210>  5771
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNMB2__Homo_sapiens__NP_001265840

<400>  5771

Met Phe Ile Trp Thr Ser Gly Arg Thr Ser Ser Ser Tyr Arg His Asp 
1               5                   10                  15      


Glu Lys Arg Asn Ile Tyr Gln Lys Ile Arg Asp His Asp Leu Leu Asp 
            20                  25                  30          


Lys Arg Lys Thr Val Thr Ala Leu Lys Ala Gly Glu Asp Arg Ala Ile 
        35                  40                  45              


Leu Leu Gly Leu Ala Met Met Val Cys Ser Ile Met Met Tyr Phe Leu 
    50                  55                  60                  


Leu Gly Ile Thr Leu Leu Arg Ser Tyr Met Gln Ser Val Trp Thr Glu 
65                  70                  75                  80  


Glu Ser Gln Cys Thr Leu Leu Asn Ala Ser Ile Thr Glu Thr Phe Asn 
                85                  90                  95      


Cys Ser Phe Ser Cys Gly Pro Asp Cys Trp Lys Leu Ser Gln Tyr Pro 
            100                 105                 110         


Cys Leu Gln Val Tyr Val Asn Leu Thr Ser Ser Gly Glu Lys Leu Leu 
        115                 120                 125             


Leu Tyr His Thr Glu Glu Thr Ile Lys Ile Asn Gln Lys Cys Ser Tyr 
    130                 135                 140                 


Ile Pro Lys Cys Gly Lys Asn Phe Glu Glu Ser Met Ser Leu Val Asn 
145                 150                 155                 160 


Val Val Met Glu Asn Phe Arg Lys Tyr Gln His Phe Ser Cys Tyr Ser 
                165                 170                 175     


Asp Pro Glu Gly Asn Gln Lys Ser Val Ile Leu Thr Lys Leu Tyr Ser 
            180                 185                 190         


Ser Asn Val Leu Phe His Ser Leu Phe Trp Pro Thr Cys Met Met Ala 
        195                 200                 205             


Gly Gly Val Ala Ile Val Ala Met Val Lys Leu Thr Gln Tyr Leu Ser 
    210                 215                 220                 


Leu Leu Cys Glu Arg Ile Gln Arg Ile Asn Arg 
225                 230                 235 


<210>  5772
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNMB3__Homo_sapiens__NP_001157149

<400>  5772

Met Gln Pro Phe Ser Ile Pro Val Gln Ile Thr Leu Gln Gly Ser Arg 
1               5                   10                  15      


Arg Arg Gln Gly Arg Thr Ala Phe Pro Ala Ser Gly Lys Lys Arg Glu 
            20                  25                  30          


Thr Asp Tyr Ser Asp Gly Asp Pro Leu Asp Val His Lys Arg Leu Pro 
        35                  40                  45              


Ser Ser Ala Gly Glu Asp Arg Ala Val Met Leu Gly Phe Ala Met Met 
    50                  55                  60                  


Gly Phe Ser Val Leu Met Phe Phe Leu Leu Gly Thr Thr Ile Leu Lys 
65                  70                  75                  80  


Pro Phe Met Leu Ser Ile Gln Arg Glu Glu Ser Thr Cys Thr Ala Ile 
                85                  90                  95      


His Thr Asp Ile Met Asp Asp Trp Leu Asp Cys Ala Phe Thr Cys Gly 
            100                 105                 110         


Val His Cys His Gly Gln Gly Lys Tyr Pro Cys Leu Gln Val Phe Val 
        115                 120                 125             


Asn Leu Ser His Pro Gly Gln Lys Ala Leu Leu His Tyr Asn Glu Glu 
    130                 135                 140                 


Ala Val Gln Ile Asn Pro Lys Arg Asp Val Thr Asp Cys Arg Val Lys 
145                 150                 155                 160 


Glu Lys Gln Thr Leu Thr Val Ser Asp Glu His Lys Gln 
                165                 170             


<210>  5773
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNMB4__Homo_sapiens__NP_055320

<400>  5773

Met Ala Lys Leu Arg Val Ala Tyr Glu Tyr Thr Glu Ala Glu Asp Lys 
1               5                   10                  15      


Ser Ile Arg Leu Gly Leu Phe Leu Ile Ile Ser Gly Val Val Ser Leu 
            20                  25                  30          


Phe Ile Phe Gly Phe Cys Trp Leu Ser Pro Ala Leu Gln Asp Leu Gln 
        35                  40                  45              


Ala Thr Glu Ala Asn Cys Thr Val Leu Ser Val Gln Gln Ile Gly Glu 
    50                  55                  60                  


Val Phe Glu Cys Thr Phe Thr Cys Gly Ala Asp Cys Arg Gly Thr Ser 
65                  70                  75                  80  


Gln Tyr Pro Cys Val Gln Val Tyr Val Asn Asn Ser Glu Ser Asn Ser 
                85                  90                  95      


Arg Ala Leu Leu His Ser Asp Glu His Gln Leu Leu Thr Asn Pro Lys 
            100                 105                 110         


Cys Ser Tyr Ile Pro Pro Cys Lys Arg Glu Asn Gln Lys Asn Leu Glu 
        115                 120                 125             


Ser Val Met Asn Trp Gln Gln Tyr Trp Lys Asp Glu Ile Gly Ser Gln 
    130                 135                 140                 


Pro Phe Thr Cys Tyr Phe Asn Gln His Gln Arg Pro Asp Asp Val Leu 
145                 150                 155                 160 


Leu His Arg Thr His Asp Glu Ile Val Leu Leu His Cys Phe Leu Trp 
                165                 170                 175     


Pro Leu Val Thr Phe Val Val Gly Val Leu Ile Val Val Leu Thr Ile 
            180                 185                 190         


Cys Ala Lys Ser Leu Ala Val Lys Ala Glu Ala Met Lys Lys Arg Lys 
        195                 200                 205             


Phe Ser 
    210 


<210>  5774
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNN1__Homo_sapiens__NP_002239

<400>  5774

Met Asn Ser His Ser Tyr Asn Gly Ser Val Gly Arg Pro Leu Gly Ser 
1               5                   10                  15      


Gly Pro Gly Ala Leu Gly Arg Asp Pro Pro Asp Pro Glu Ala Gly His 
            20                  25                  30          


Pro Pro Gln Pro Pro His Ser Pro Gly Leu Gln Val Val Val Ala Lys 
        35                  40                  45              


Ser Glu Pro Ala Arg Pro Ser Pro Gly Ser Pro Arg Gly Gln Pro Gln 
    50                  55                  60                  


Asp Gln Asp Asp Asp Glu Asp Asp Glu Glu Asp Glu Ala Gly Arg Gln 
65                  70                  75                  80  


Arg Ala Ser Gly Lys Pro Ser Asn Val Gly His Arg Leu Gly His Arg 
                85                  90                  95      


Arg Ala Leu Phe Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu Ile 
            100                 105                 110         


Phe Gly Met Phe Gly Ile Val Val Met Val Thr Glu Thr Glu Leu Ser 
        115                 120                 125             


Trp Gly Val Tyr Thr Lys Glu Ser Leu Tyr Ser Phe Ala Leu Lys Cys 
    130                 135                 140                 


Leu Ile Ser Leu Ser Thr Ala Ile Leu Leu Gly Leu Val Val Leu Tyr 
145                 150                 155                 160 


His Ala Arg Glu Ile Gln Leu Phe Met Val Asp Asn Gly Ala Asp Asp 
                165                 170                 175     


Trp Arg Ile Ala Met Thr Cys Glu Arg Val Phe Leu Ile Ser Leu Glu 
            180                 185                 190         


Leu Ala Val Cys Ala Ile His Pro Val Pro Gly His Tyr Arg Phe Thr 
        195                 200                 205             


Trp Thr Ala Arg Leu Ala Phe Thr Tyr Ala Pro Ser Val Ala Glu Ala 
    210                 215                 220                 


Asp Val Asp Val Leu Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu 
225                 230                 235                 240 


Leu Gly Arg Val Met Leu Leu His Ser Lys Ile Phe Thr Asp Ala Ser 
                245                 250                 255     


Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Thr Phe Asn Thr Arg Phe 
            260                 265                 270         


Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val 
        275                 280                 285             


Phe Ser Ile Ser Ser Trp Ile Ile Ala Ala Trp Thr Val Arg Val Cys 
    290                 295                 300                 


Glu Arg Tyr His Asp Lys Gln Glu Val Thr Ser Asn Phe Leu Gly Ala 
305                 310                 315                 320 


Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
                325                 330                 335     


Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
            340                 345                 350         


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
        355                 360                 365             


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    370                 375                 380                 


Thr Gln Leu Thr Lys Arg Val Lys Asn Ala Ala Ala Asn Val Leu Arg 
385                 390                 395                 400 


Glu Thr Trp Leu Ile Tyr Lys His Thr Arg Leu Val Lys Lys Pro Asp 
                405                 410                 415     


Gln Ala Arg Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
            420                 425                 430         


Gln Ala Gln Lys Leu Arg Ser Val Lys Ile Glu Gln Gly Lys Leu Asn 
        435                 440                 445             


Asp Gln Ala Asn Thr Leu Thr Asp Leu Ala Lys Thr Gln Thr Val Met 
    450                 455                 460                 


Tyr Asp Leu Val Ser Glu Leu His Ala Gln His Glu Glu Leu Glu Ala 
465                 470                 475                 480 


Arg Leu Ala Thr Leu Glu Ser Arg Leu Asp Ala Leu Gly Ala Ser Leu 
                485                 490                 495     


Gln Ala Leu Pro Gly Leu Ile Ala Gln Ala Ile Arg Pro Pro Pro Pro 
            500                 505                 510         


Pro Leu Pro Pro Arg Pro Gly Pro Gly Pro Gln Asp Gln Ala Ala Arg 
        515                 520                 525             


Ser Ser Pro Cys Arg Trp Thr Pro Val Ala Pro Ser Asp Cys Gly 
    530                 535                 540             


<210>  5775
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNN2__Homo_sapiens__NP_067627

<400>  5775

Met Ser Ser Cys Arg Tyr Asn Gly Gly Val Met Arg Pro Leu Ser Asn 
1               5                   10                  15      


Leu Ser Ala Ser Arg Arg Asn Leu His Glu Met Asp Ser Glu Ala Gln 
            20                  25                  30          


Pro Leu Gln Pro Pro Ala Ser Val Gly Gly Gly Gly Gly Ala Ser Ser 
        35                  40                  45              


Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser Ser Ala Pro 
    50                  55                  60                  


Glu Ile Val Val Ser Lys Pro Glu His Asn Asn Ser Asn Asn Leu Ala 
65                  70                  75                  80  


Leu Tyr Gly Thr Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly His Gly Ser Ser Ser Gly Thr Lys Ser Ser Lys Lys 
            100                 105                 110         


Lys Asn Gln Asn Ile Gly Tyr Lys Leu Gly His Arg Arg Ala Leu Phe 
        115                 120                 125             


Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu Ile Phe Gly Met Phe 
    130                 135                 140                 


Gly Ile Val Val Met Val Ile Glu Thr Glu Leu Ser Trp Gly Ala Tyr 
145                 150                 155                 160 


Asp Lys Ala Ser Leu Tyr Ser Leu Ala Leu Lys Cys Leu Ile Ser Leu 
                165                 170                 175     


Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Val Tyr His Ala Arg Glu 
            180                 185                 190         


Ile Gln Leu Phe Met Val Asp Asn Gly Ala Asp Asp Trp Arg Ile Ala 
        195                 200                 205             


Met Thr Tyr Glu Arg Ile Phe Phe Ile Cys Leu Glu Ile Leu Val Cys 
    210                 215                 220                 


Ala Ile His Pro Ile Pro Gly Asn Tyr Thr Phe Thr Trp Thr Ala Arg 
225                 230                 235                 240 


Leu Ala Phe Ser Tyr Ala Pro Ser Thr Thr Thr Ala Asp Val Asp Ile 
                245                 250                 255     


Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu Ile Ala Arg Val 
            260                 265                 270         


Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala Ser Ser Arg Ser Ile 
        275                 280                 285             


Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg Phe Val Met Lys Thr 
    290                 295                 300                 


Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val Phe Ser Ile Ser 
305                 310                 315                 320 


Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Ala Cys Glu Arg Tyr His 
                325                 330                 335     


Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly Ala Met Trp Leu Ile 
            340                 345                 350         


Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met Val Pro Asn Thr 
        355                 360                 365             


Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile Met Gly Ala Gly 
    370                 375                 380                 


Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys Leu Glu Leu Thr 
385                 390                 395                 400 


Lys Ala Glu Lys His Val His Asn Phe Met Met Asp Thr Gln Leu Thr 
                405                 410                 415     


Lys Arg Val Lys Asn Ala Ala Ala Asn Val Leu Arg Glu Thr Trp Leu 
            420                 425                 430         


Ile Tyr Lys Asn Thr Lys Leu Val Lys Lys Ile Asp His Ala Lys Val 
        435                 440                 445             


Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His Gln Leu Arg Ser 
    450                 455                 460                 


Val Lys Met Glu Gln Arg Lys Leu Asn Asp Gln Ala Asn Thr Leu Val 
465                 470                 475                 480 


Asp Leu Ala Lys Thr Gln Asn Ile Met Tyr Asp Met Ile Ser Asp Leu 
                485                 490                 495     


Asn Glu Arg Ser Glu Asp Phe Glu Lys Arg Ile Val Thr Leu Glu Thr 
            500                 505                 510         


Lys Leu Glu Thr Leu Ile Gly Ser Ile His Ala Leu Pro Gly Leu Ile 
        515                 520                 525             


Ser Gln Thr Ile Arg Gln Gln Gln Arg Asp Phe Ile Glu Ala Gln Met 
    530                 535                 540                 


Glu Ser Tyr Asp Lys His Val Thr Tyr Asn Ala Glu Arg Ser Arg Ser 
545                 550                 555                 560 


Ser Ser Arg Arg Arg Arg Ser Ser Ser Thr Ala Pro Pro Thr Ser Ser 
                565                 570                 575     


Glu Ser Ser 
            


<210>  5776
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNN3__Homo_sapiens__NP_002240

<400>  5776

Met Asp Thr Ser Gly His Phe His Asp Ser Gly Val Gly Asp Leu Asp 
1               5                   10                  15      


Glu Asp Pro Lys Cys Pro Cys Pro Ser Ser Gly Asp Glu Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Ala Pro Pro 
        35                  40                  45              


Ala Ala Pro Gln Gln Pro Leu Gly Pro Ser Leu Gln Pro Gln Pro Pro 
    50                  55                  60                  


Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Pro Pro His Pro Leu Ser Gln Leu Ala Gln Leu Gln Ser Gln Pro Val 
                85                  90                  95      


His Pro Gly Leu Leu His Ser Ser Pro Thr Ala Phe Arg Ala Pro Pro 
            100                 105                 110         


Ser Ser Asn Ser Thr Ala Ile Leu His Pro Ser Ser Arg Gln Gly Ser 
        115                 120                 125             


Gln Leu Asn Leu Asn Asp His Leu Leu Gly His Ser Pro Ser Ser Thr 
    130                 135                 140                 


Ala Thr Ser Gly Pro Gly Gly Gly Ser Arg His Arg Gln Ala Ser Pro 
145                 150                 155                 160 


Leu Val His Arg Arg Asp Ser Asn Pro Phe Thr Glu Ile Ala Met Ser 
                165                 170                 175     


Ser Cys Lys Tyr Ser Gly Gly Val Met Lys Pro Leu Ser Arg Leu Ser 
            180                 185                 190         


Ala Ser Arg Arg Asn Leu Ile Glu Ala Glu Thr Glu Gly Gln Pro Leu 
        195                 200                 205             


Gln Leu Phe Ser Pro Ser Asn Pro Pro Glu Ile Val Ile Ser Ser Arg 
    210                 215                 220                 


Glu Asp Asn His Ala His Gln Thr Leu Leu His His Pro Asn Ala Thr 
225                 230                 235                 240 


His Asn His Gln His Ala Gly Thr Thr Ala Ser Ser Thr Thr Phe Pro 
                245                 250                 255     


Lys Ala Asn Lys Arg Lys Asn Gln Asn Ile Gly Tyr Lys Leu Gly His 
            260                 265                 270         


Arg Arg Ala Leu Phe Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu 
        275                 280                 285             


Ile Phe Gly Met Phe Gly Ile Val Val Met Val Ile Glu Thr Glu Leu 
    290                 295                 300                 


Ser Trp Gly Leu Tyr Ser Lys Asp Ser Met Phe Ser Leu Ala Leu Lys 
305                 310                 315                 320 


Cys Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Ala 
                325                 330                 335     


Tyr His Thr Arg Glu Val Gln Leu Phe Val Ile Asp Asn Gly Ala Asp 
            340                 345                 350         


Asp Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile Leu Tyr Ile Ser Leu 
        355                 360                 365             


Glu Met Leu Val Cys Ala Ile His Pro Ile Pro Gly Glu Tyr Lys Phe 
    370                 375                 380                 


Phe Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr Pro Ser Arg Ala Glu 
385                 390                 395                 400 


Ala Asp Val Asp Ile Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr 
                405                 410                 415     


Leu Ile Ala Arg Val Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala 
            420                 425                 430         


Ser Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg 
        435                 440                 445             


Phe Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu 
    450                 455                 460                 


Val Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Val 
465                 470                 475                 480 


Cys Glu Arg Tyr His Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly 
                485                 490                 495     


Ala Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp 
            500                 505                 510         


Met Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly 
        515                 520                 525             


Ile Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg 
    530                 535                 540                 


Lys Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met 
545                 550                 555                 560 


Asp Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala Ala Ala Asn Val Leu 
                565                 570                 575     


Arg Glu Thr Trp Leu Ile Tyr Lys His Thr Lys Leu Leu Lys Lys Ile 
            580                 585                 590         


Asp His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile 
        595                 600                 605             


His Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Ser Asp Gln 
    610                 615                 620                 


Ala Asn Thr Leu Val Asp Leu Ser Lys Met Gln Asn Val Met Tyr Asp 
625                 630                 635                 640 


Leu Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp Leu Glu Lys Gln Ile 
                645                 650                 655     


Gly Ser Leu Glu Ser Lys Leu Glu His Leu Thr Ala Ser Phe Asn Ser 
            660                 665                 670         


Leu Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln Gln Gln Gln Gln Leu 
        675                 680                 685             


Leu Ser Ala Ile Ile Glu Ala Arg Gly Val Ser Val Ala Val Gly Thr 
    690                 695                 700                 


Thr His Thr Pro Ile Ser Asp Ser Pro Ile Gly Val Ser Ser Thr Ser 
705                 710                 715                 720 


Phe Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
                725                 730     


<210>  5777
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNN4__Homo_sapiens__NP_002241

<400>  5777

Met Gly Gly Asp Leu Val Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys 
1               5                   10                  15      


Arg Leu Leu Glu Gln Glu Lys Ser Leu Ala Gly Trp Ala Leu Val Leu 
            20                  25                  30          


Ala Gly Thr Gly Ile Gly Leu Met Val Leu His Ala Glu Met Leu Trp 
        35                  40                  45              


Phe Gly Gly Cys Ser Trp Ala Leu Tyr Leu Phe Leu Val Lys Cys Thr 
    50                  55                  60                  


Ile Ser Ile Ser Thr Phe Leu Leu Leu Cys Leu Ile Val Ala Phe His 
65                  70                  75                  80  


Ala Lys Glu Val Gln Leu Phe Met Thr Asp Asn Gly Leu Arg Asp Trp 
                85                  90                  95      


Arg Val Ala Leu Thr Gly Arg Gln Ala Ala Gln Ile Val Leu Glu Leu 
            100                 105                 110         


Val Val Cys Gly Leu His Pro Ala Pro Val Arg Gly Pro Pro Cys Val 
        115                 120                 125             


Gln Asp Leu Gly Ala Pro Leu Thr Ser Pro Gln Pro Trp Pro Gly Phe 
    130                 135                 140                 


Leu Gly Gln Gly Glu Ala Leu Leu Ser Leu Ala Met Leu Leu Arg Leu 
145                 150                 155                 160 


Tyr Leu Val Pro Arg Ala Val Leu Leu Arg Ser Gly Val Leu Leu Asn 
                165                 170                 175     


Ala Ser Tyr Arg Ser Ile Gly Ala Leu Asn Gln Val Arg Phe Arg His 
            180                 185                 190         


Trp Phe Val Ala Lys Leu Tyr Met Asn Thr His Pro Gly Arg Leu Leu 
        195                 200                 205             


Leu Gly Leu Thr Leu Gly Leu Trp Leu Thr Thr Ala Trp Val Leu Ser 
    210                 215                 220                 


Val Ala Glu Arg Gln Ala Val Asn Ala Thr Gly His Leu Ser Asp Thr 
225                 230                 235                 240 


Leu Trp Leu Ile Pro Ile Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val 
                245                 250                 255     


Val Pro Gly Thr Met Trp Gly Lys Ile Val Cys Leu Cys Thr Gly Val 
            260                 265                 270         


Met Gly Val Cys Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys 
        275                 280                 285             


Leu Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    290                 295                 300                 


Ile Gln Tyr Thr Lys Glu Met Lys Glu Ser Ala Ala Arg Val Leu Gln 
305                 310                 315                 320 


Glu Ala Trp Met Phe Tyr Lys His Thr Arg Arg Lys Glu Ser His Ala 
                325                 330                 335     


Ala Arg Arg His Gln Arg Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg 
            340                 345                 350         


Gln Val Arg Leu Lys His Arg Lys Leu Arg Glu Gln Val Asn Ser Met 
        355                 360                 365             


Val Asp Ile Ser Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn 
    370                 375                 380                 


Leu Ser Ser Ser His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala 
385                 390                 395                 400 


Gly Lys Leu Asp Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro 
                405                 410                 415     


Arg Gln Leu Pro Glu Pro Ser Gln Gln Ser Lys 
            420                 425         


<210>  5778
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNQ1__Homo_sapiens__NP_000209

<400>  5778

Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly 
1               5                   10                  15      


Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys 
            20                  25                  30          


Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly 
        35                  40                  45              


Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly 
65                  70                  75                  80  


Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr 
                85                  90                  95      


Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn 
            100                 105                 110         


Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala 
        115                 120                 125             


Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr 
    130                 135                 140                 


Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu 
145                 150                 155                 160 


Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp 
                165                 170                 175     


Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg 
            180                 185                 190         


Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala 
        195                 200                 205             


Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr 
    210                 215                 220                 


Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His 
225                 230                 235                 240 


Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe 
                245                 250                 255     


Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly 
            260                 265                 270         


Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val 
        275                 280                 285             


Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp 
    290                 295                 300                 


Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro 
305                 310                 315                 320 


Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala 
                325                 330                 335     


Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala 
            340                 345                 350         


Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile 
        355                 360                 365             


Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala 
    370                 375                 380                 


Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro 
385                 390                 395                 400 


Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val 
                405                 410                 415     


Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr 
            420                 425                 430         


Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro 
        435                 440                 445             


Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser 
    450                 455                 460                 


Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met 
465                 470                 475                 480 


Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu 
                485                 490                 495     


Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala 
            500                 505                 510         


Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys 
        515                 520                 525             


Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln 
    530                 535                 540                 


Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln 
545                 550                 555                 560 


Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val 
                565                 570                 575     


Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu 
            580                 585                 590         


Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu 
        595                 600                 605             


Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr 
    610                 615                 620                 


Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln 
625                 630                 635                 640 


Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser 
                645                 650                 655     


Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro 
            660                 665                 670         


Asp Glu Gly Ser 
        675     


<210>  5779
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNQ2__Homo_sapiens__NP_004509

<400>  5779

Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Arg Leu Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu 
    370                 375                 380                 


Arg Asn Leu Lys Ser Lys Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro 
385                 390                 395                 400 


Pro Glu Pro Ser Pro Ser Gln Lys Val Ser Leu Lys Asp Arg Val Phe 
                405                 410                 415     


Ser Ser Pro Arg Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala 
            420                 425                 430         


Gln Thr Val Arg Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser 
        435                 440                 445             


Pro Ser Lys Val Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala 
    450                 455                 460                 


Arg Gln Ala Phe Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu 
465                 470                 475                 480 


Glu Ala Ser Leu Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro 
                485                 490                 495     


Cys Glu Phe Val Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile 
            500                 505                 510         


Arg Ala Val Cys Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys 
        515                 520                 525             


Glu Ser Leu Arg Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser 
    530                 535                 540                 


Ala Gly His Leu Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg 
545                 550                 555                 560 


Val Asp Gln Ile Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg 
                565                 570                 575     


Thr Lys Gly Pro Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met 
            580                 585                 590         


Gly Arg Leu Gly Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys 
        595                 600                 605             


Leu Asp Phe Leu Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro 
    610                 615                 620                 


Thr Glu Thr Glu Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro 
625                 630                 635                 640 


Pro Tyr His Ser Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly 
                645                 650                 655     


Cys Ile Val Lys Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn 
            660                 665                 670         


Phe Ser Ala Pro Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr 
        675                 680                 685             


Ser Trp Gln Pro Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro 
    690                 695                 700                 


Val Gly Asp His Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His 
705                 710                 715                 720 


Glu Arg Ser Leu Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu 
                725                 730                 735     


Phe Leu Arg Gln Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn 
            740                 745                 750         


Leu Arg Asp Ser Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu 
        755                 760                 765             


Glu Leu Glu Arg Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu 
    770                 775                 780                 


Asn Leu Asp Ala Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala 
785                 790                 795                 800 


Lys Val Arg Pro Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp 
                805                 810                 815     


Leu Cys Thr Pro Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly 
            820                 825                 830         


Pro Phe Gly Asp Val Gly Trp Ala Gly Pro Arg Lys 
        835                 840                 


<210>  5780
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNQ3__Homo_sapiens__NP_001191753

<400>  5780

Met Lys Pro Ala Glu His Ala Thr Met Phe Leu Ile Val Leu Gly Cys 
1               5                   10                  15      


Leu Ile Leu Ala Val Leu Thr Thr Phe Lys Glu Tyr Glu Thr Val Ser 
            20                  25                  30          


Gly Asp Trp Leu Leu Leu Leu Glu Thr Phe Ala Ile Phe Ile Phe Gly 
        35                  40                  45              


Ala Glu Phe Ala Leu Arg Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr 
    50                  55                  60                  


Lys Gly Trp Arg Gly Arg Leu Lys Phe Ala Arg Lys Pro Leu Cys Met 
65                  70                  75                  80  


Leu Asp Ile Phe Val Leu Ile Ala Ser Val Pro Val Val Ala Val Gly 
                85                  90                  95      


Asn Gln Gly Asn Val Leu Ala Thr Ser Leu Arg Ser Leu Arg Phe Leu 
            100                 105                 110         


Gln Ile Leu Arg Met Leu Arg Met Asp Arg Arg Gly Gly Thr Trp Lys 
        115                 120                 125             


Leu Leu Gly Ser Ala Ile Cys Ala His Ser Lys Glu Leu Ile Thr Ala 
    130                 135                 140                 


Trp Tyr Ile Gly Phe Leu Thr Leu Ile Leu Ser Ser Phe Leu Val Tyr 
145                 150                 155                 160 


Leu Val Glu Lys Asp Val Pro Glu Val Asp Ala Gln Gly Glu Glu Met 
                165                 170                 175     


Lys Glu Glu Phe Glu Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu Ile 
            180                 185                 190         


Thr Leu Ala Thr Ile Gly Tyr Gly Asp Lys Thr Pro Lys Thr Trp Glu 
        195                 200                 205             


Gly Arg Leu Ile Ala Ala Thr Phe Ser Leu Ile Gly Val Ser Phe Phe 
    210                 215                 220                 


Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Leu Ala Leu Lys Val Gln 
225                 230                 235                 240 


Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Lys Pro Ala Ala 
                245                 250                 255     


Glu Leu Ile Gln Ala Ala Trp Arg Tyr Tyr Ala Thr Asn Pro Asn Arg 
            260                 265                 270         


Ile Asp Leu Val Ala Thr Trp Arg Phe Tyr Glu Ser Val Val Ser Phe 
        275                 280                 285             


Pro Phe Phe Arg Lys Glu Gln Leu Glu Ala Ala Ser Ser Gln Lys Leu 
    290                 295                 300                 


Gly Leu Leu Asp Arg Val Arg Leu Ser Asn Pro Arg Gly Ser Asn Thr 
305                 310                 315                 320 


Lys Gly Lys Leu Phe Thr Pro Leu Asn Val Asp Ala Ile Glu Glu Ser 
                325                 330                 335     


Pro Ser Lys Glu Pro Lys Pro Val Gly Leu Asn Asn Lys Glu Arg Phe 
            340                 345                 350         


Arg Thr Ala Phe Arg Met Lys Ala Tyr Ala Phe Trp Gln Ser Ser Glu 
        355                 360                 365             


Asp Ala Gly Thr Gly Asp Pro Met Ala Glu Asp Arg Gly Tyr Gly Asn 
    370                 375                 380                 


Asp Phe Pro Ile Glu Asp Met Ile Pro Thr Leu Lys Ala Ala Ile Arg 
385                 390                 395                 400 


Ala Val Arg Ile Leu Gln Phe Arg Leu Tyr Lys Lys Lys Phe Lys Glu 
                405                 410                 415     


Thr Leu Arg Pro Tyr Asp Val Lys Asp Val Ile Glu Gln Tyr Ser Ala 
            420                 425                 430         


Gly His Leu Asp Met Leu Ser Arg Ile Lys Tyr Leu Gln Thr Arg Ile 
        435                 440                 445             


Asp Met Ile Phe Thr Pro Gly Pro Pro Ser Thr Pro Lys His Lys Lys 
    450                 455                 460                 


Ser Gln Lys Gly Ser Ala Phe Thr Phe Pro Ser Gln Gln Ser Pro Arg 
465                 470                 475                 480 


Asn Glu Pro Tyr Val Ala Arg Pro Ser Thr Ser Glu Ile Glu Asp Gln 
                485                 490                 495     


Ser Met Met Gly Lys Phe Val Lys Val Glu Arg Gln Val Gln Asp Met 
            500                 505                 510         


Gly Lys Lys Leu Asp Phe Leu Val Asp Met His Met Gln His Met Glu 
        515                 520                 525             


Arg Leu Gln Val Gln Val Thr Glu Tyr Tyr Pro Thr Lys Gly Thr Ser 
    530                 535                 540                 


Ser Pro Ala Glu Ala Glu Lys Lys Glu Asp Asn Arg Tyr Ser Asp Leu 
545                 550                 555                 560 


Lys Thr Ile Ile Cys Asn Tyr Ser Glu Thr Gly Pro Pro Glu Pro Pro 
                565                 570                 575     


Tyr Ser Phe His Gln Val Thr Ile Asp Lys Val Ser Pro Tyr Gly Phe 
            580                 585                 590         


Phe Ala His Asp Pro Val Asn Leu Pro Arg Gly Gly Pro Ser Ser Gly 
        595                 600                 605             


Lys Val Gln Ala Thr Pro Pro Ser Ser Ala Thr Thr Tyr Val Glu Arg 
    610                 615                 620                 


Pro Thr Val Leu Pro Ile Leu Thr Leu Leu Asp Ser Arg Val Ser Cys 
625                 630                 635                 640 


His Ser Gln Ala Asp Leu Gln Gly Pro Tyr Ser Asp Arg Ile Ser Pro 
                645                 650                 655     


Arg Gln Arg Arg Ser Ile Thr Arg Asp Ser Asp Thr Pro Leu Ser Leu 
            660                 665                 670         


Met Ser Val Asn His Glu Glu Leu Glu Arg Ser Pro Ser Gly Phe Ser 
        675                 680                 685             


Ile Ser Gln Asp Arg Asp Asp Tyr Val Phe Gly Pro Asn Gly Gly Ser 
    690                 695                 700                 


Ser Trp Met Arg Glu Lys Arg Tyr Leu Ala Glu Gly Glu Thr Asp Thr 
705                 710                 715                 720 


Asp Thr Asp Pro Phe Thr Pro Ser Gly Ser Met Pro Leu Ser Ser Thr 
                725                 730                 735     


Gly Asp Gly Ile Ser Asp Ser Val Trp Thr Pro Ser Asn Lys Pro Ile 
            740                 745                 750         


<210>  5781
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNQ5__Homo_sapiens__NP_001153602

<400>  5781

Met Pro Arg His His Ala Gly Gly Glu Glu Gly Gly Ala Ala Gly Leu 
1               5                   10                  15      


Trp Val Lys Ser Gly Ala Ala Ala Ala Ala Ala Gly Gly Gly Arg Leu 
            20                  25                  30          


Gly Ser Gly Met Lys Asp Val Glu Ser Gly Arg Gly Arg Val Leu Leu 
        35                  40                  45              


Asn Ser Ala Ala Ala Arg Gly Asp Gly Leu Leu Leu Leu Gly Thr Arg 
    50                  55                  60                  


Ala Ala Thr Leu Gly Gly Gly Gly Gly Gly Leu Arg Glu Ser Arg Arg 
65                  70                  75                  80  


Gly Lys Gln Gly Ala Arg Met Ser Leu Leu Gly Lys Pro Leu Ser Tyr 
                85                  90                  95      


Thr Ser Ser Gln Ser Cys Arg Arg Asn Val Lys Tyr Arg Arg Val Gln 
            100                 105                 110         


Asn Tyr Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile 
        115                 120                 125             


Tyr His Ala Phe Val Phe Leu Leu Val Phe Gly Cys Leu Ile Leu Ser 
    130                 135                 140                 


Val Phe Ser Thr Ile Pro Glu His Thr Lys Leu Ala Ser Ser Cys Leu 
145                 150                 155                 160 


Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly Leu Glu Phe Ile 
                165                 170                 175     


Ile Arg Ile Trp Ser Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Gln 
            180                 185                 190         


Gly Arg Leu Arg Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Thr Ile 
        195                 200                 205             


Val Leu Ile Ala Ser Ile Ala Val Val Ser Ala Lys Thr Gln Gly Asn 
    210                 215                 220                 


Ile Phe Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu 
225                 230                 235                 240 


Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly 
                245                 250                 255     


Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile 
            260                 265                 270         


Gly Phe Leu Val Leu Ile Phe Ser Ser Phe Leu Val Tyr Leu Val Glu 
        275                 280                 285             


Lys Asp Ala Asn Lys Glu Phe Ser Thr Tyr Ala Asp Ala Leu Trp Trp 
    290                 295                 300                 


Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Thr Pro Leu 
305                 310                 315                 320 


Thr Trp Leu Gly Arg Leu Leu Ser Ala Gly Phe Ala Leu Leu Gly Ile 
                325                 330                 335     


Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu 
            340                 345                 350         


Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn 
        355                 360                 365             


Pro Ala Ala Asn Leu Ile Gln Cys Val Trp Arg Ser Tyr Ala Ala Asp 
    370                 375                 380                 


Glu Lys Ser Val Ser Ile Ala Thr Trp Lys Pro His Leu Lys Ala Leu 
385                 390                 395                 400 


His Thr Cys Ser Pro Thr Asn Gln Lys Leu Ser Phe Lys Glu Arg Val 
                405                 410                 415     


Arg Met Ala Ser Pro Arg Gly Gln Ser Ile Lys Ser Arg Gln Ala Ser 
            420                 425                 430         


Val Gly Asp Arg Arg Ser Pro Ser Thr Asp Ile Thr Ala Glu Gly Ser 
        435                 440                 445             


Pro Thr Lys Val Gln Lys Ser Trp Ser Phe Asn Asp Arg Thr Arg Phe 
    450                 455                 460                 


Arg Pro Ser Leu Arg Leu Lys Ser Ser Gln Pro Lys Pro Val Ile Asp 
465                 470                 475                 480 


Ala Asp Thr Ala Leu Gly Thr Asp Asp Val Tyr Asp Glu Lys Gly Cys 
                485                 490                 495     


Gln Cys Asp Val Ser Val Glu Asp Leu Thr Pro Pro Leu Lys Thr Val 
            500                 505                 510         


Ile Arg Ala Ile Arg Ile Met Lys Phe His Val Ala Lys Arg Lys Phe 
        515                 520                 525             


Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys Asp Val Ile Glu Gln Tyr 
    530                 535                 540                 


Ser Ala Gly His Leu Asp Met Leu Cys Arg Ile Lys Ser Leu Gln Thr 
545                 550                 555                 560 


Arg Val Asp Gln Ile Leu Gly Lys Gly Gln Ile Thr Ser Asp Lys Lys 
                565                 570                 575     


Ser Arg Glu Lys Ile Thr Ala Glu His Glu Thr Thr Asp Asp Leu Ser 
            580                 585                 590         


Met Leu Gly Arg Val Val Lys Val Glu Lys Gln Val Gln Ser Ile Glu 
        595                 600                 605             


Ser Lys Leu Asp Cys Leu Leu Asp Ile Tyr Gln Gln Val Leu Arg Lys 
    610                 615                 620                 


Gly Ser Ala Ser Ala Leu Ala Leu Ala Ser Phe Gln Ile Pro Pro Phe 
625                 630                 635                 640 


Glu Cys Glu Gln Thr Ser Asp Tyr Gln Ser Pro Val Asp Ser Lys Asp 
                645                 650                 655     


Leu Ser Gly Ser Ala Gln Asn Ser Gly Cys Leu Ser Arg Ser Thr Ser 
            660                 665                 670         


Ala Asn Ile Ser Arg Gly Leu Gln Phe Ile Leu Thr Pro Asn Glu Phe 
        675                 680                 685             


Ser Ala Gln Thr Phe Tyr Ala Leu Ser Pro Thr Met His Ser Gln Ala 
    690                 695                 700                 


Thr Gln Val Pro Ile Ser Gln Ser Asp Gly Ser Ala Val Ala Ala Thr 
705                 710                 715                 720 


Asn Thr Ile Ala Asn Gln Ile Asn Thr Ala Pro Lys Pro Ala Ala Pro 
                725                 730                 735     


Thr Thr Leu Gln Ile Pro Pro Pro Leu Pro Ala Ile Lys His Leu Pro 
            740                 745                 750         


Arg Pro Glu Thr Leu His Pro Asn Pro Ala Gly Leu Gln Glu Ser Ile 
        755                 760                 765             


Ser Asp Val Thr Thr Cys Leu Val Ala Ser Lys Glu Asn Val Gln Val 
    770                 775                 780                 


Ala Gln Ser Asn Leu Thr Lys Asp Arg Ser Met Arg Lys Ser Phe Asp 
785                 790                 795                 800 


Met Gly Gly Glu Thr Leu Leu Ser Val Cys Pro Met Val Pro Lys Asp 
                805                 810                 815     


Leu Gly Lys Ser Leu Ser Val Gln Asn Leu Ile Arg Ser Thr Glu Glu 
            820                 825                 830         


Leu Asn Ile Gln Leu Ser Gly Ser Glu Ser Ser Gly Ser Arg Gly Ser 
        835                 840                 845             


Gln Asp Phe Tyr Pro Lys Trp Arg Glu Ser Lys Leu Phe Ile Thr Asp 
    850                 855                 860                 


Glu Glu Val Gly Pro Glu Glu Thr Glu Thr Asp Thr Phe Asp Ala Ala 
865                 870                 875                 880 


Pro Gln Pro Ala Arg Glu Ala Ala Phe Ala Ser Asp Ser Leu Arg Thr 
                885                 890                 895     


Gly Arg Ser Arg Ser Ser Gln Ser Ile Cys Lys Ala Gly Glu Ser Thr 
            900                 905                 910         


Asp Ala Leu Ser Leu Pro His Val Lys Leu Lys 
        915                 920             


<210>  5782
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNRG__Homo_sapiens__NP_775876

<400>  5782

Met Ser Ser Gln Glu Leu Val Thr Leu Asn Val Gly Gly Lys Ile Phe 
1               5                   10                  15      


Thr Thr Arg Phe Ser Thr Ile Lys Gln Phe Pro Ala Ser Arg Leu Ala 
            20                  25                  30          


Arg Met Leu Asp Gly Arg Asp Gln Glu Phe Lys Met Val Gly Gly Gln 
        35                  40                  45              


Ile Phe Val Asp Arg Asp Gly Asp Leu Phe Ser Phe Ile Leu Asp Phe 
    50                  55                  60                  


Leu Arg Thr His Gln Leu Leu Leu Pro Thr Glu Phe Ser Asp Tyr Leu 
65                  70                  75                  80  


Arg Leu Gln Arg Glu Ala Leu Phe Tyr Glu Leu Arg Ser Leu Val Asp 
                85                  90                  95      


Leu Leu Asn Pro Tyr Leu Leu Gln Pro Arg Pro Ala Leu Val Glu Val 
            100                 105                 110         


His Phe Leu Ser Arg Asn Thr Gln Ala Phe Phe Arg Val Phe Gly Ser 
        115                 120                 125             


Cys Ser Lys Thr Ile Glu Met Leu Thr Gly Arg Ile Thr Val Phe Thr 
    130                 135                 140                 


Glu Gln Pro Ser Ala Pro Thr Trp Asn Gly Asn Phe Phe Pro Pro Gln 
145                 150                 155                 160 


Met Thr Leu Leu Pro Leu Pro Pro Gln Arg Pro Ser Tyr His Asp Leu 
                165                 170                 175     


Val Phe Gln Cys Gly Ser Asp Ser Thr Thr Asp Asn Gln Thr Gly Val 
            180                 185                 190         


Arg Tyr Val Ser Ile Lys Pro Asp Asn Arg Lys Leu Ala Asn Gly Thr 
        195                 200                 205             


Asn Val Leu Gly Leu Leu Ile Asp Thr Leu Leu Lys Glu Gly Phe His 
    210                 215                 220                 


Leu Val Ser Thr Arg Thr Val Ser Ser Glu Asp Lys Thr Glu Cys Tyr 
225                 230                 235                 240 


Ser Phe Glu Arg Ile Lys Ser Pro Glu Val Leu Ile Thr Asn Glu Thr 
                245                 250                 255     


Pro Lys Pro Glu Thr Ile Ile Ile Pro Glu Gln Ser Gln Ile Lys Lys 
            260                 265                 270         


<210>  5783
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNS1__Homo_sapiens__XP_005260466

<400>  5783

Met Leu Met Leu Leu Val Arg Gly Thr His Tyr Glu Asn Leu Arg Ser 
1               5                   10                  15      


Lys Val Val Leu Pro Thr Pro Leu Gly Gly Arg Ser Thr Glu Thr Phe 
            20                  25                  30          


Val Ser Glu Phe Pro Gly Pro Asp Thr Gly Ile Arg Trp Arg Arg Ser 
        35                  40                  45              


Asp Glu Ala Leu Arg Val Asn Val Gly Gly Val Arg Arg Gln Leu Ser 
    50                  55                  60                  


Ala Arg Ala Leu Ala Arg Phe Pro Gly Thr Arg Leu Gly Arg Leu Gln 
65                  70                  75                  80  


Ala Ala Ala Ser Glu Glu Gln Ala Arg Arg Leu Cys Asp Asp Tyr Asp 
                85                  90                  95      


Glu Ala Ala Arg Glu Phe Tyr Phe Asp Arg His Pro Gly Phe Phe Leu 
            100                 105                 110         


Ser Leu Leu His Phe Tyr Arg Thr Gly His Leu His Val Leu Asp Glu 
        115                 120                 125             


Leu Cys Val Phe Ala Phe Gly Gln Glu Ala Asp Tyr Trp Gly Leu Gly 
    130                 135                 140                 


Glu Asn Ala Leu Ala Ala Cys Cys Arg Ala Arg Tyr Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Thr Gln Pro His Ala Trp Asp Glu Asp Ser Asp Thr Pro Ser Ser 
                165                 170                 175     


Val Asp Pro Cys Pro Asp Glu Ile Ser Asp Val Gln Arg Glu Leu Ala 
            180                 185                 190         


Arg Tyr Gly Ala Ala Arg Cys Gly Arg Leu Arg Arg Arg Leu Trp Leu 
        195                 200                 205             


Thr Met Glu Asn Pro Gly Tyr Ser Leu Pro Ser Lys Leu Phe Ser Cys 
    210                 215                 220                 


Val Ser Ile Ser Val Val Leu Ala Ser Ile Ala Ala Met Cys Ile His 
225                 230                 235                 240 


Ser Leu Pro Glu Tyr Gln Ala Arg Glu Ala Ala Ala Ala Val Ala Ala 
                245                 250                 255     


Val Ala Ala Gly Arg Ser Pro Glu Gly Val Arg Asp Asp Pro Val Leu 
            260                 265                 270         


Arg Arg Leu Glu Tyr Phe Cys Ile Ala Trp Phe Ser Phe Glu Val Ser 
        275                 280                 285             


Ser Arg Leu Leu Leu Ala Pro Ser Thr Arg Asn Phe Phe Cys His Pro 
    290                 295                 300                 


Leu Asn Leu Ile Asp Ile Val Ser Val Leu Pro Phe Tyr Leu Thr Leu 
305                 310                 315                 320 


Leu Ala Gly Val Ala Leu Gly Asp Gln Gly Gly Lys Glu Phe Gly His 
                325                 330                 335     


Leu Gly Lys Val Val Gln Val Phe Arg Leu Met Arg Ile Phe Arg Val 
            340                 345                 350         


Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ser Leu Gly Ala Thr 
        355                 360                 365             


Leu Lys His Ser Tyr Arg Glu Val Gly Ile Leu Leu Leu Tyr Leu Ala 
    370                 375                 380                 


Val Gly Val Ser Val Phe Ser Gly Val Ala Tyr Thr Ala Glu Lys Glu 
385                 390                 395                 400 


Glu Asp Val Gly Phe Asn Thr Ile Pro Ala Cys Trp Trp Trp Gly Thr 
                405                 410                 415     


Val Ser Met Thr Thr Val Gly Tyr Gly Asp Val Val Pro Val Thr Val 
            420                 425                 430         


Ala Gly Lys Leu Ala Ala Ser Gly Cys Ile Leu Gly Gly Ile Leu Val 
        435                 440                 445             


Val Ala Leu Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser His Phe Tyr 
    450                 455                 460                 


Arg Arg Gln Lys Ala Leu Glu Ala Ala Val Arg Asn Ser Asn His Gln 
465                 470                 475                 480 


Glu Phe Glu Asp Leu Leu Ser Ser Ile Asp Gly Val Ser Glu Ala Ser 
                485                 490                 495     


Leu Glu Thr Ser Arg Glu Thr Ser Gln Glu Gly Gln Ser Ala Asp Leu 
            500                 505                 510         


Glu Ser Gln Ala Pro Ser Glu Pro Pro His Pro Gln Met Tyr 
        515                 520                 525     


<210>  5784
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNS3__Homo_sapiens__XP_011531127

<400>  5784

Met Val Phe Gly Glu Phe Phe His Arg Pro Gly Gln Asp Glu Glu Leu 
1               5                   10                  15      


Val Asn Leu Asn Val Gly Gly Phe Lys Gln Ser Val Asp Gln Ser Thr 
            20                  25                  30          


Leu Leu Arg Phe Pro His Thr Arg Leu Gly Lys Leu Leu Thr Cys His 
        35                  40                  45              


Ser Glu Glu Ala Ile Leu Glu Leu Cys Asp Asp Tyr Ser Val Ala Asp 
    50                  55                  60                  


Lys Glu Tyr Tyr Phe Asp Arg Asn Pro Ser Leu Phe Arg Tyr Val Leu 
65                  70                  75                  80  


Asn Phe Tyr Tyr Thr Gly Lys Leu His Val Met Glu Glu Leu Cys Val 
                85                  90                  95      


Phe Ser Phe Cys Gln Glu Ile Glu Tyr Trp Gly Ile Asn Glu Leu Phe 
            100                 105                 110         


Ile Asp Ser Cys Cys Ser Asn Arg Tyr Gln Glu Arg Lys Glu Glu Asn 
        115                 120                 125             


His Glu Lys Asp Trp Asp Gln Lys Ser His Asp Val Ser Thr Asp Ser 
    130                 135                 140                 


Ser Phe Glu Glu Ser Ser Leu Phe Glu Lys Glu Leu Glu Lys Phe Asp 
145                 150                 155                 160 


Thr Leu Arg Phe Gly Gln Leu Arg Lys Lys Ile Trp Ile Arg Met Glu 
                165                 170                 175     


Asn Pro Ala Tyr Cys Leu Ser Ala Lys Leu Ile Ala Ile Ser Ser Leu 
            180                 185                 190         


Ser Val Val Leu Ala Ser Ile Val Ala Met Cys Val His Ser Met Ser 
        195                 200                 205             


Glu Phe Gln Asn Glu Asp Gly Glu Val Asp Asp Pro Val Leu Glu Gly 
    210                 215                 220                 


Val Glu Ile Ala Cys Ile Ala Trp Phe Thr Gly Glu Leu Ala Val Arg 
225                 230                 235                 240 


Leu Ala Ala Ala Pro Cys Gln Lys Lys Phe Trp Lys Asn Pro Leu Asn 
                245                 250                 255     


Ile Ile Asp Phe Val Ser Ile Ile Pro Phe Tyr Ala Thr Leu Ala Val 
            260                 265                 270         


Asp Thr Lys Glu Glu Glu Ser Glu Asp Ile Glu Asn Met Gly Lys Val 
        275                 280                 285             


Val Gln Ile Leu Arg Leu Met Arg Ile Phe Arg Ile Leu Lys Leu Ala 
    290                 295                 300                 


Arg His Ser Val Gly Leu Arg Ser Leu Gly Ala Thr Leu Arg His Ser 
305                 310                 315                 320 


Tyr His Glu Val Gly Leu Leu Leu Leu Phe Leu Ser Val Gly Ile Ser 
                325                 330                 335     


Ile Phe Ser Val Leu Ile Tyr Ser Val Glu Lys Asp Asp His Thr Ser 
            340                 345                 350         


Ser Leu Thr Ser Ile Pro Ile Cys Trp Trp Trp Ala Thr Ile Ser Met 
        355                 360                 365             


Thr Thr Val Gly Tyr Gly Asp Thr His Pro Val Thr Leu Ala Gly Lys 
    370                 375                 380                 


Leu Ile Ala Ser Thr Cys Ile Ile Cys Gly Ile Leu Val Val Ala Leu 
385                 390                 395                 400 


Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser Lys Tyr Tyr Gln Lys Gln 
                405                 410                 415     


Lys Asp Ile Asp Val Asp Gln Cys Ser Glu Asp Ala Pro Glu Lys Cys 
            420                 425                 430         


His Glu Leu Pro Tyr Phe Asn Ile Arg Asp Ile Tyr Ala Gln Arg Met 
        435                 440                 445             


His Thr Phe Ile Thr Ser Leu Ser Ser Val Gly Ile Val Val Ser Asp 
    450                 455                 460                 


Pro Asp Ser Thr Asp Ala Ser Ser Ile Glu Asp Asn Glu Asp Ile Cys 
465                 470                 475                 480 


Asn Thr Thr Ser Leu Glu Asn Cys Thr Ala Lys 
                485                 490     


<210>  5785
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNT1__Homo_sapiens__NP_065873

<400>  5785

Met Pro Leu Pro Asp Gly Ala Arg Thr Pro Gly Gly Val Cys Arg Glu 
1               5                   10                  15      


Ala Arg Gly Gly Gly Tyr Thr Asn Arg Thr Phe Glu Phe Asp Asp Gly 
            20                  25                  30          


Gln Cys Ala Pro Arg Arg Pro Cys Ala Gly Asp Gly Ala Leu Leu Asp 
        35                  40                  45              


Thr Ala Gly Phe Lys Met Ser Asp Leu Asp Ser Glu Val Leu Pro Leu 
    50                  55                  60                  


Pro Pro Arg Tyr Arg Phe Arg Asp Leu Leu Leu Gly Asp Pro Ser Phe 
65                  70                  75                  80  


Gln Asn Asp Asp Arg Val Gln Val Glu Phe Tyr Val Asn Glu Asn Thr 
                85                  90                  95      


Phe Lys Glu Arg Leu Lys Leu Phe Phe Ile Lys Asn Gln Arg Ser Ser 
            100                 105                 110         


Leu Arg Ile Arg Leu Phe Asn Phe Ser Leu Lys Leu Leu Thr Cys Leu 
        115                 120                 125             


Leu Tyr Ile Val Arg Val Leu Leu Asp Asp Pro Ala Leu Gly Ile Gly 
    130                 135                 140                 


Cys Trp Gly Cys Pro Lys Gln Asn Tyr Ser Phe Asn Asp Ser Ser Ser 
145                 150                 155                 160 


Glu Ile Asn Trp Ala Pro Ile Leu Trp Val Glu Arg Lys Met Thr Leu 
                165                 170                 175     


Trp Ala Ile Gln Val Ile Val Ala Ile Ile Ser Phe Leu Glu Thr Met 
            180                 185                 190         


Leu Leu Ile Tyr Leu Ser Tyr Lys Gly Asn Ile Trp Glu Gln Ile Phe 
        195                 200                 205             


Arg Val Ser Phe Val Leu Glu Met Ile Asn Thr Leu Pro Phe Ile Ile 
    210                 215                 220                 


Thr Ile Phe Trp Pro Pro Leu Arg Asn Leu Phe Ile Pro Val Phe Leu 
225                 230                 235                 240 


Asn Cys Trp Leu Ala Lys His Ala Leu Glu Asn Met Ile Asn Asp Phe 
                245                 250                 255     


His Arg Ala Ile Leu Arg Thr Gln Ser Ala Met Phe Asn Gln Val Leu 
            260                 265                 270         


Ile Leu Phe Cys Thr Leu Leu Cys Leu Val Phe Thr Gly Thr Cys Gly 
        275                 280                 285             


Ile Gln His Leu Glu Arg Ala Gly Glu Asn Leu Ser Leu Leu Thr Ser 
    290                 295                 300                 


Phe Tyr Phe Cys Ile Val Thr Phe Ser Thr Val Gly Tyr Gly Asp Val 
305                 310                 315                 320 


Thr Pro Lys Ile Trp Pro Ser Gln Leu Leu Val Val Ile Met Ile Cys 
                325                 330                 335     


Val Ala Leu Val Val Leu Pro Leu Gln Phe Glu Glu Leu Val Tyr Leu 
            340                 345                 350         


Trp Met Glu Arg Gln Lys Ser Gly Gly Asn Tyr Ser Arg His Arg Ala 
        355                 360                 365             


Gln Thr Glu Lys His Val Val Leu Cys Val Ser Ser Leu Lys Ile Asp 
    370                 375                 380                 


Leu Leu Met Asp Phe Leu Asn Glu Phe Tyr Ala His Pro Arg Leu Gln 
385                 390                 395                 400 


Asp Tyr Tyr Val Val Ile Leu Cys Pro Thr Glu Met Asp Val Gln Val 
                405                 410                 415     


Arg Arg Val Leu Gln Ile Pro Leu Trp Ser Gln Arg Val Ile Tyr Leu 
            420                 425                 430         


Gln Gly Ser Ala Leu Lys Asp Gln Asp Leu Met Arg Ala Lys Met Asp 
        435                 440                 445             


Asn Gly Glu Ala Cys Phe Ile Leu Ser Ser Arg Asn Glu Val Asp Arg 
    450                 455                 460                 


Thr Ala Ala Asp His Gln Thr Ile Leu Arg Ala Trp Ala Val Lys Asp 
465                 470                 475                 480 


Phe Ala Pro Asn Cys Pro Leu Tyr Val Gln Ile Leu Lys Pro Glu Asn 
                485                 490                 495     


Lys Phe His Val Lys Phe Ala Asp His Val Val Cys Glu Glu Glu Cys 
            500                 505                 510         


Lys Tyr Ala Met Leu Ala Leu Asn Cys Ile Cys Pro Ala Thr Ser Thr 
        515                 520                 525             


Leu Ile Thr Leu Leu Val His Thr Ser Arg Gly Gln Glu Gly Gln Glu 
    530                 535                 540                 


Ser Pro Glu Gln Trp Gln Arg Met Tyr Gly Arg Cys Ser Gly Asn Glu 
545                 550                 555                 560 


Val Tyr His Ile Arg Met Gly Asp Ser Lys Phe Phe Arg Glu Tyr Glu 
                565                 570                 575     


Gly Lys Ser Phe Thr Tyr Ala Ala Phe His Ala His Lys Lys Tyr Gly 
            580                 585                 590         


Val Cys Leu Ile Gly Leu Lys Arg Glu Asp Asn Lys Ser Ile Leu Leu 
        595                 600                 605             


Asn Pro Gly Pro Arg His Ile Leu Ala Ala Ser Asp Thr Cys Phe Tyr 
    610                 615                 620                 


Ile Asn Ile Thr Lys Glu Glu Asn Ser Ala Phe Ile Phe Lys Gln Glu 
625                 630                 635                 640 


Glu Lys Arg Lys Lys Arg Ala Phe Ser Gly Gln Gly Leu His Glu Gly 
                645                 650                 655     


Pro Ala Arg Leu Pro Val His Ser Ile Ile Ala Ser Met Gly Thr Val 
            660                 665                 670         


Ala Met Asp Leu Gln Gly Thr Glu His Arg Pro Thr Gln Ser Gly Gly 
        675                 680                 685             


Gly Gly Gly Gly Ser Lys Leu Ala Leu Pro Thr Glu Asn Gly Ser Gly 
    690                 695                 700                 


Ser Arg Arg Pro Ser Ile Ala Pro Val Leu Glu Leu Ala Asp Ser Ser 
705                 710                 715                 720 


Ala Leu Leu Pro Cys Asp Leu Leu Ser Asp Gln Ser Glu Asp Glu Val 
                725                 730                 735     


Thr Pro Ser Asp Asp Glu Gly Leu Ser Val Val Glu Tyr Val Lys Gly 
            740                 745                 750         


Tyr Pro Pro Asn Ser Pro Tyr Ile Gly Ser Ser Pro Thr Leu Cys His 
        755                 760                 765             


Leu Leu Pro Val Lys Ala Pro Phe Cys Cys Leu Arg Leu Asp Lys Gly 
    770                 775                 780                 


Cys Lys His Asn Ser Tyr Glu Asp Ala Lys Ala Tyr Gly Phe Lys Asn 
785                 790                 795                 800 


Lys Leu Ile Ile Val Ser Ala Glu Thr Ala Gly Asn Gly Leu Tyr Asn 
                805                 810                 815     


Phe Ile Val Pro Leu Arg Ala Tyr Tyr Arg Ser Arg Lys Glu Leu Asn 
            820                 825                 830         


Pro Ile Val Leu Leu Leu Asp Asn Lys Pro Asp His His Phe Leu Glu 
        835                 840                 845             


Ala Ile Cys Cys Phe Pro Met Val Tyr Tyr Met Glu Gly Ser Val Asp 
    850                 855                 860                 


Asn Leu Asp Ser Leu Leu Gln Cys Gly Ile Ile Tyr Ala Asp Asn Leu 
865                 870                 875                 880 


Val Val Val Asp Lys Glu Ser Thr Met Ser Ala Glu Glu Asp Tyr Met 
                885                 890                 895     


Ala Asp Ala Lys Thr Ile Val Asn Val Gln Thr Met Phe Arg Leu Phe 
            900                 905                 910         


Pro Ser Leu Ser Ile Thr Thr Glu Leu Thr His Pro Ser Asn Met Arg 
        915                 920                 925             


Phe Met Gln Phe Arg Ala Lys Asp Ser Tyr Ser Leu Ala Leu Ser Lys 
    930                 935                 940                 


Leu Glu Lys Arg Glu Arg Glu Asn Gly Ser Asn Leu Ala Phe Met Phe 
945                 950                 955                 960 


Arg Leu Pro Phe Ala Ala Gly Arg Val Phe Ser Ile Ser Met Leu Asp 
                965                 970                 975     


Thr Leu Leu Tyr Gln Ser Phe Val Lys Asp Tyr Met Ile Thr Ile Thr 
            980                 985                 990         


Arg Leu Leu Leu Gly Leu Asp Thr  Thr Pro Gly Ser Gly  Tyr Leu Cys 
        995                 1000                 1005             


Ala Met  Lys Ile Thr Glu Gly  Asp Leu Trp Ile Arg  Thr Tyr Gly 
    1010                 1015                 1020             


Arg Leu  Phe Gln Lys Leu Cys  Ser Ser Ser Ala Glu  Ile Pro Ile 
    1025                 1030                 1035             


Gly Ile  Tyr Arg Thr Glu Ser  His Val Phe Ser Thr  Ser Glu Pro 
    1040                 1045                 1050             


His Asp  Leu Arg Ala Gln Ser  Gln Ile Ser Val Asn  Val Glu Asp 
    1055                 1060                 1065             


Cys Glu  Asp Thr Arg Glu Val  Lys Gly Pro Trp Gly  Ser Arg Ala 
    1070                 1075                 1080             


Gly Thr  Gly Gly Ser Ser Gln  Gly Arg His Thr Gly  Gly Gly Asp 
    1085                 1090                 1095             


Pro Ala  Glu His Pro Leu Leu  Arg Arg Lys Ser Leu  Gln Trp Ala 
    1100                 1105                 1110             


Arg Arg  Leu Ser Arg Lys Ala  Pro Lys Gln Ala Gly  Arg Ala Ala 
    1115                 1120                 1125             


Ala Ala  Glu Trp Ile Ser Gln  Gln Arg Leu Ser Leu  Tyr Arg Arg 
    1130                 1135                 1140             


Ser Glu  Arg Gln Glu Leu Ser  Glu Leu Val Lys Asn  Arg Met Lys 
    1145                 1150                 1155             


His Leu  Gly Leu Pro Thr Thr  Gly Tyr Asp Glu Met  Asn Asp His 
    1160                 1165                 1170             


Gln Asn  Thr Leu Ser Tyr Val  Leu Ile Asn Pro Pro  Pro Asp Thr 
    1175                 1180                 1185             


Arg Leu  Glu Pro Ser Asp Ile  Val Tyr Leu Ile Arg  Ser Asp Pro 
    1190                 1195                 1200             


Leu Ala  His Val Ala Ser Ser  Ser Gln Ser Arg Lys  Ser Ser Cys 
    1205                 1210                 1215             


Ser His  Lys Leu Ser Ser Cys  Asn Pro Glu Thr Arg  Asp Glu Thr 
    1220                 1225                 1230             


Gln Leu  
    1235 


<210>  5786
<211>  1111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNT2__Homo_sapiens__NP_001274748

<400>  5786

Met Val Asp Leu Glu Ser Glu Val Pro Pro Leu Pro Pro Arg Tyr Arg 
1               5                   10                  15      


Phe Arg Asp Leu Leu Leu Gly Asp Gln Gly Trp Gln Asn Asp Asp Arg 
            20                  25                  30          


Val Gln Val Glu Phe Tyr Met Asn Glu Asn Thr Phe Lys Glu Arg Leu 
        35                  40                  45              


Lys Leu Phe Phe Ile Lys Asn Gln Arg Ser Ser Leu Arg Ile Arg Leu 
    50                  55                  60                  


Phe Asn Phe Ser Leu Lys Leu Leu Ser Cys Leu Leu Tyr Ile Ile Arg 
65                  70                  75                  80  


Val Leu Leu Glu Asn Pro Ser Gln Gly Asn Glu Trp Ser His Ile Phe 
                85                  90                  95      


Trp Val Asn Arg Ser Leu Pro Leu Trp Gly Leu Gln Val Ser Val Ala 
            100                 105                 110         


Leu Ile Ser Leu Phe Glu Thr Ile Leu Leu Gly Tyr Leu Ser Tyr Lys 
        115                 120                 125             


Gly Asn Ile Trp Glu Gln Ile Leu Arg Ile Pro Phe Ile Leu Glu Ile 
    130                 135                 140                 


Ile Asn Ala Val Pro Phe Ile Ile Ser Ile Phe Trp Pro Ser Leu Arg 
145                 150                 155                 160 


Asn Leu Phe Val Pro Val Phe Leu Asn Cys Trp Leu Ala Lys His Ala 
                165                 170                 175     


Leu Glu Asn Met Ile Asn Asp Leu His Arg Ala Ile Gln Arg Thr Gln 
            180                 185                 190         


Ser Ala Met Phe Asn Gln Val Leu Ile Leu Ile Ser Thr Leu Leu Cys 
        195                 200                 205             


Leu Ile Phe Thr Cys Ile Cys Gly Ile Gln His Leu Glu Arg Ile Gly 
    210                 215                 220                 


Lys Lys Leu Asn Leu Phe Asp Ser Leu Tyr Phe Cys Ile Val Thr Phe 
225                 230                 235                 240 


Ser Thr Val Gly Phe Gly Asp Val Thr Pro Glu Thr Trp Ser Ser Lys 
                245                 250                 255     


Leu Phe Val Val Ala Met Ile Cys Val Ala Leu Val Val Leu Pro Ile 
            260                 265                 270         


Gln Phe Glu Gln Leu Ala Tyr Leu Trp Met Glu Arg Gln Lys Ser Gly 
        275                 280                 285             


Gly Asn Tyr Ser Arg His Arg Ala Gln Thr Glu Lys His Val Val Leu 
    290                 295                 300                 


Cys Val Ser Ser Leu Lys Ile Asp Leu Leu Met Asp Phe Leu Asn Glu 
305                 310                 315                 320 


Phe Tyr Ala His Pro Arg Leu Gln Asp Tyr Tyr Val Val Ile Leu Cys 
                325                 330                 335     


Pro Thr Glu Met Asp Val Gln Val Arg Arg Val Leu Gln Ile Pro Met 
            340                 345                 350         


Trp Ser Gln Arg Val Ile Tyr Leu Gln Gly Ser Ala Leu Lys Asp Gln 
        355                 360                 365             


Asp Leu Leu Arg Ala Lys Met Asp Asp Ala Glu Ala Cys Phe Ile Leu 
    370                 375                 380                 


Ser Ser Arg Cys Glu Val Asp Arg Thr Ser Ser Asp His Gln Thr Ile 
385                 390                 395                 400 


Leu Arg Ala Trp Ala Val Lys Asp Phe Ala Pro Asn Cys Pro Leu Tyr 
                405                 410                 415     


Val Gln Ile Leu Lys Pro Glu Asn Lys Phe His Ile Lys Phe Ala Asp 
            420                 425                 430         


His Val Val Cys Glu Glu Glu Phe Lys Tyr Ala Met Leu Ala Leu Asn 
        435                 440                 445             


Cys Ile Cys Pro Ala Thr Ser Thr Leu Ile Thr Leu Leu Val His Thr 
    450                 455                 460                 


Ser Arg Gly Gln Glu Gly Gln Gln Ser Pro Glu Gln Trp Gln Lys Met 
465                 470                 475                 480 


Tyr Gly Arg Cys Ser Gly Asn Glu Val Tyr His Ile Val Leu Glu Glu 
                485                 490                 495     


Ser Thr Phe Phe Ala Glu Tyr Glu Gly Lys Ser Phe Thr Tyr Ala Ser 
            500                 505                 510         


Phe His Ala His Lys Lys Phe Gly Val Cys Leu Ile Gly Val Arg Arg 
        515                 520                 525             


Glu Asp Asn Lys Asn Ile Leu Leu Asn Pro Gly Pro Arg Tyr Ile Met 
    530                 535                 540                 


Asn Ser Thr Asp Ile Cys Phe Tyr Ile Asn Ile Thr Lys Glu Glu Asn 
545                 550                 555                 560 


Ser Ala Phe Lys Asn Gln Asp Gln Gln Arg Lys Ser Asn Val Ser Arg 
                565                 570                 575     


Ser Phe Tyr His Gly Pro Ser Arg Leu Pro Val His Ser Ile Ile Ala 
            580                 585                 590         


Ser Met Gly Thr Val Ala Ile Asp Leu Gln Asp Thr Ser Cys Arg Ser 
        595                 600                 605             


Ala Ser Gly Pro Thr Leu Ser Leu Pro Thr Glu Gly Ser Lys Glu Ile 
    610                 615                 620                 


Arg Arg Pro Ser Ile Ala Pro Val Leu Glu Val Ala Asp Thr Ser Ser 
625                 630                 635                 640 


Ile Gln Thr Cys Asp Leu Leu Ser Asp Gln Ser Glu Asp Glu Thr Thr 
                645                 650                 655     


Pro Asp Glu Glu Met Ser Ser Asn Leu Glu Tyr Ala Lys Gly Tyr Pro 
            660                 665                 670         


Pro Tyr Ser Pro Tyr Ile Gly Ser Ser Pro Thr Phe Cys His Leu Leu 
        675                 680                 685             


His Glu Lys Val Pro Phe Cys Cys Leu Arg Leu Asp Lys Ser Cys Gln 
    690                 695                 700                 


His Asn Tyr Tyr Glu Asp Ala Lys Ala Tyr Gly Phe Lys Asn Lys Leu 
705                 710                 715                 720 


Ile Ile Val Ala Ala Glu Thr Ala Gly Asn Gly Leu Tyr Asn Phe Ile 
                725                 730                 735     


Val Pro Leu Arg Ala Tyr Tyr Arg Pro Lys Lys Glu Leu Asn Pro Ile 
            740                 745                 750         


Val Leu Leu Leu Asp Asn Pro Leu Asp Asp Leu Leu Arg Cys Gly Val 
        755                 760                 765             


Thr Phe Ala Ala Asn Met Val Val Val Asp Lys Glu Ser Thr Met Ser 
    770                 775                 780                 


Ala Glu Glu Asp Tyr Met Ala Asp Ala Lys Thr Ile Val Asn Val Gln 
785                 790                 795                 800 


Thr Leu Phe Arg Leu Phe Ser Ser Leu Ser Ile Ile Thr Glu Leu Thr 
                805                 810                 815     


His Pro Ala Asn Met Arg Phe Met Gln Phe Arg Ala Lys Asp Cys Tyr 
            820                 825                 830         


Ser Leu Ala Leu Ser Lys Leu Glu Lys Lys Glu Arg Glu Arg Gly Ser 
        835                 840                 845             


Asn Leu Ala Phe Met Phe Arg Leu Pro Phe Ala Ala Gly Arg Val Phe 
    850                 855                 860                 


Ser Ile Ser Met Leu Asp Thr Leu Leu Tyr Gln Ser Phe Val Lys Asp 
865                 870                 875                 880 


Tyr Met Ile Ser Ile Thr Arg Leu Leu Leu Gly Leu Asp Thr Thr Pro 
                885                 890                 895     


Gly Ser Gly Phe Leu Cys Ser Met Lys Ile Thr Ala Asp Asp Leu Trp 
            900                 905                 910         


Ile Arg Thr Tyr Ala Arg Leu Tyr Gln Lys Leu Cys Ser Ser Thr Gly 
        915                 920                 925             


Asp Val Pro Ile Gly Ile Tyr Arg Thr Glu Ser Gln Lys Leu Thr Thr 
    930                 935                 940                 


Ser Glu Ser Gln Ile Ser Ile Ser Val Glu Glu Trp Glu Asp Thr Lys 
945                 950                 955                 960 


Asp Ser Lys Glu Gln Gly His His Arg Ser Asn His Arg Asn Ser Thr 
                965                 970                 975     


Ser Ser Asp Gln Ser Asp His Pro Leu Leu Arg Arg Lys Ser Met Gln 
            980                 985                 990         


Trp Ala Arg Arg Leu Ser Arg Lys  Gly Pro Lys His Ser  Gly Lys Thr 
        995                 1000                 1005             


Ala Glu  Lys Ile Thr Gln Gln  Arg Leu Asn Leu Tyr  Arg Arg Ser 
    1010                 1015                 1020             


Glu Arg  Gln Glu Leu Ala Glu  Leu Val Lys Asn Arg  Met Lys His 
    1025                 1030                 1035             


Leu Gly  Leu Ser Thr Val Gly  Tyr Asp Glu Met Asn  Asp His Gln 
    1040                 1045                 1050             


Ser Thr  Leu Ser Tyr Ile Leu  Ile Asn Pro Ser Pro  Asp Thr Arg 
    1055                 1060                 1065             


Ile Glu  Leu Asn Asp Val Val  Tyr Leu Ile Arg Pro  Asp Pro Leu 
    1070                 1075                 1080             


Ala Tyr  Leu Pro Asn Ser Glu  Pro Ser Arg Arg Asn  Ser Ile Cys 
    1085                 1090                 1095             


Asn Val  Thr Gly Gln Asp Ser  Arg Glu Glu Thr Gln  Leu 
    1100                 1105                 1110     


<210>  5787
<211>  1149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNU1__Homo_sapiens__NP_001027006

<400>  5787

Met Phe Gln Thr Lys Leu Arg Asn Glu Thr Trp Glu Asp Leu Pro Lys 
1               5                   10                  15      


Met Ser Cys Thr Thr Glu Ile Gln Ala Ala Phe Ile Leu Ser Ser Phe 
            20                  25                  30          


Val Thr Phe Phe Ser Gly Leu Ile Ile Leu Leu Ile Phe Arg Leu Ile 
        35                  40                  45              


Trp Arg Ser Val Lys Lys Trp Gln Ile Ile Lys Gly Thr Gly Ile Ile 
    50                  55                  60                  


Leu Glu Leu Phe Thr Ser Gly Thr Ile Ala Arg Ser His Val Arg Ser 
65                  70                  75                  80  


Leu His Phe Gln Gly Gln Phe Arg Asp His Ile Glu Met Leu Leu Ser 
                85                  90                  95      


Ala Gln Thr Phe Val Gly Gln Val Leu Val Ile Leu Val Phe Val Leu 
            100                 105                 110         


Ser Ile Gly Ser Leu Ile Ile Tyr Phe Ile Asn Ser Ala Asp Pro Val 
        115                 120                 125             


Gly Ser Cys Ser Ser Tyr Glu Asp Lys Thr Ile Pro Ile Asp Leu Val 
    130                 135                 140                 


Phe Asn Ala Phe Phe Ser Phe Tyr Phe Gly Leu Arg Phe Met Ala Ala 
145                 150                 155                 160 


Asp Asp Lys Ile Lys Phe Trp Leu Glu Met Asn Ser Ile Val Asp Ile 
                165                 170                 175     


Phe Thr Ile Pro Pro Thr Phe Ile Ser Tyr Tyr Leu Lys Ser Asn Trp 
            180                 185                 190         


Leu Gly Leu Arg Phe Leu Arg Ala Leu Arg Leu Leu Glu Leu Pro Gln 
        195                 200                 205             


Ile Leu Gln Ile Leu Arg Ala Ile Lys Thr Ser Asn Ser Val Lys Phe 
    210                 215                 220                 


Ser Lys Leu Leu Ser Ile Ile Leu Ser Thr Trp Phe Thr Ala Ala Gly 
225                 230                 235                 240 


Phe Ile His Leu Val Glu Asn Ser Gly Asp Pro Trp Leu Lys Gly Arg 
                245                 250                 255     


Asn Ser Gln Asn Ile Ser Tyr Phe Glu Ser Ile Tyr Leu Val Met Ala 
            260                 265                 270         


Thr Thr Ser Thr Val Gly Phe Gly Asp Val Val Ala Lys Thr Ser Leu 
        275                 280                 285             


Gly Arg Thr Phe Ile Met Phe Phe Thr Leu Gly Ser Leu Ile Leu Phe 
    290                 295                 300                 


Ala Asn Tyr Ile Pro Glu Met Val Glu Leu Phe Ala Asn Lys Arg Lys 
305                 310                 315                 320 


Tyr Thr Ser Ser Tyr Glu Ala Leu Lys Gly Lys Lys Phe Ile Val Val 
                325                 330                 335     


Cys Gly Asn Ile Thr Val Asp Ser Val Thr Ala Phe Leu Arg Asn Phe 
            340                 345                 350         


Leu Arg Asp Lys Ser Gly Glu Ile Asn Thr Glu Ile Val Phe Leu Gly 
        355                 360                 365             


Glu Thr Pro Pro Ser Leu Glu Leu Glu Thr Ile Phe Lys Cys Tyr Leu 
    370                 375                 380                 


Ala Tyr Thr Thr Phe Ile Ser Gly Ser Ala Met Lys Trp Glu Asp Leu 
385                 390                 395                 400 


Arg Arg Val Ala Val Glu Ser Ala Glu Ala Cys Leu Ile Ile Ala Asn 
                405                 410                 415     


Pro Leu Cys Ser Asp Ser His Ala Glu Asp Ile Ser Asn Ile Met Arg 
            420                 425                 430         


Val Leu Ser Ile Lys Asn Tyr Asp Ser Thr Thr Arg Ile Ile Ile Gln 
        435                 440                 445             


Ile Leu Gln Ser His Asn Lys Val Tyr Leu Pro Lys Ile Pro Ser Trp 
    450                 455                 460                 


Asn Trp Asp Thr Gly Asp Asn Ile Ile Cys Phe Ala Glu Leu Lys Leu 
465                 470                 475                 480 


Gly Phe Ile Ala Gln Gly Cys Leu Val Pro Gly Leu Cys Thr Phe Leu 
                485                 490                 495     


Thr Ser Leu Phe Val Glu Gln Asn Lys Lys Val Met Pro Lys Gln Thr 
            500                 505                 510         


Trp Lys Lys His Phe Leu Asn Ser Met Lys Asn Lys Ile Leu Thr Gln 
        515                 520                 525             


Arg Leu Ser Asp Asp Phe Ala Gly Met Ser Phe Pro Glu Val Ala Arg 
    530                 535                 540                 


Leu Cys Phe Leu Lys Met His Leu Leu Leu Ile Ala Ile Glu Tyr Lys 
545                 550                 555                 560 


Ser Leu Phe Thr Asp Gly Phe Cys Gly Leu Ile Leu Asn Pro Pro Pro 
                565                 570                 575     


Gln Val Arg Ile Arg Lys Asn Thr Leu Gly Phe Phe Ile Ala Glu Thr 
            580                 585                 590         


Pro Lys Asp Val Arg Arg Ala Leu Phe Tyr Cys Ser Val Cys His Asp 
        595                 600                 605             


Asp Val Phe Ile Pro Glu Leu Ile Thr Asn Cys Gly Cys Lys Ser Arg 
    610                 615                 620                 


Ser Arg Gln His Ile Thr Val Pro Ser Val Lys Arg Met Lys Lys Cys 
625                 630                 635                 640 


Leu Lys Gly Ile Ser Ser Arg Ile Ser Gly Gln Asp Ser Pro Pro Arg 
                645                 650                 655     


Val Ser Ala Ser Thr Ser Ser Ile Ser Asn Phe Thr Thr Arg Thr Leu 
            660                 665                 670         


Gln His Asp Val Glu Gln Asp Ser Asp Gln Leu Asp Ser Ser Gly Met 
        675                 680                 685             


Phe His Trp Cys Lys Pro Thr Ser Leu Asp Lys Val Thr Leu Lys Arg 
    690                 695                 700                 


Thr Gly Lys Ser Lys Tyr Lys Phe Arg Asn His Ile Val Ala Cys Val 
705                 710                 715                 720 


Phe Gly Asp Ala His Ser Ala Pro Met Gly Leu Arg Asn Phe Val Met 
                725                 730                 735     


Pro Leu Arg Ala Ser Asn Tyr Thr Arg Lys Glu Leu Lys Asp Ile Val 
            740                 745                 750         


Phe Ile Gly Ser Leu Asp Tyr Leu Gln Arg Glu Trp Arg Phe Leu Trp 
        755                 760                 765             


Asn Phe Pro Gln Ile Tyr Ile Leu Pro Gly Cys Ala Leu Tyr Ser Gly 
    770                 775                 780                 


Asp Leu His Ala Ala Asn Ile Glu Gln Cys Ser Met Cys Ala Val Leu 
785                 790                 795                 800 


Ser Pro Pro Pro Gln Pro Ser Ser Asn Gln Thr Leu Val Asp Thr Glu 
                805                 810                 815     


Ala Ile Met Ala Thr Leu Thr Ile Gly Ser Leu Gln Ile Asp Ser Ser 
            820                 825                 830         


Ser Asp Pro Ser Pro Ser Val Ser Glu Glu Thr Pro Gly Tyr Thr Asn 
        835                 840                 845             


Gly His Asn Glu Lys Ser Asn Cys Arg Lys Val Pro Ile Leu Thr Glu 
    850                 855                 860                 


Leu Lys Asn Pro Ser Asn Ile His Phe Ile Glu Gln Leu Gly Gly Leu 
865                 870                 875                 880 


Glu Gly Ser Leu Gln Glu Thr Asn Leu His Leu Ser Thr Ala Phe Ser 
                885                 890                 895     


Thr Gly Thr Val Phe Ser Gly Ser Phe Leu Asp Ser Leu Leu Ala Thr 
            900                 905                 910         


Ala Phe Tyr Asn Tyr His Val Leu Glu Leu Leu Gln Met Leu Val Thr 
        915                 920                 925             


Gly Gly Val Ser Ser Gln Leu Glu Gln His Leu Asp Lys Asp Lys Val 
    930                 935                 940                 


Tyr Gly Val Ala Asp Ser Cys Thr Ser Leu Leu Ser Gly Arg Asn Arg 
945                 950                 955                 960 


Cys Lys Leu Gly Leu Leu Ser Leu His Glu Thr Ile Leu Ser Asp Val 
                965                 970                 975     


Asn Pro Arg Asn Thr Phe Gly Gln Leu Phe Cys Gly Ser Leu Asp Leu 
            980                 985                 990         


Phe Gly Ile Leu Cys Val Gly Leu  Tyr Arg Ile Ile Asp  Glu Glu Glu 
        995                 1000                 1005             


Leu Asn  Pro Glu Asn Lys Arg  Phe Val Ile Thr Arg  Pro Ala Asn 
    1010                 1015                 1020             


Glu Phe  Lys Leu Leu Pro Ser  Asp Leu Val Phe Cys  Ala Ile Pro 
    1025                 1030                 1035             


Phe Ser  Thr Ala Cys Tyr Lys  Arg Asn Glu Glu Phe  Ser Leu Gln 
    1040                 1045                 1050             


Lys Ser  Tyr Glu Ile Val Asn  Lys Ala Ser Gln Thr  Thr Glu Thr 
    1055                 1060                 1065             


His Ser  Asp Thr Asn Cys Pro  Pro Thr Ile Asp Ser  Val Thr Glu 
    1070                 1075                 1080             


Thr Leu  Tyr Ser Pro Val Tyr  Ser Tyr Gln Pro Arg  Thr Asn Ser 
    1085                 1090                 1095             


Leu Ser  Phe Pro Lys Gln Ile  Ala Trp Asn Gln Ser  Arg Thr Asn 
    1100                 1105                 1110             


Ser Ile  Ile Ser Ser Gln Ile  Pro Leu Gly Asp Asn  Ala Lys Glu 
    1115                 1120                 1125             


Asn Glu  Arg Lys Thr Ser Asp  Glu Val Tyr Asp Glu  Asp Pro Phe 
    1130                 1135                 1140             


Ala Tyr  Ser Glu Pro Leu 
    1145                 


<210>  5788
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNV1__Homo_sapiens__NP_055194

<400>  5788

Met Pro Ser Ser Gly Arg Ala Leu Leu Asp Ser Pro Leu Asp Ser Gly 
1               5                   10                  15      


Ser Leu Thr Ser Leu Asp Ser Ser Val Phe Cys Ser Glu Gly Glu Gly 
            20                  25                  30          


Glu Pro Leu Ala Leu Gly Asp Cys Phe Thr Val Asn Val Gly Gly Ser 
        35                  40                  45              


Arg Phe Val Leu Ser Gln Gln Ala Leu Ser Cys Phe Pro His Thr Arg 
    50                  55                  60                  


Leu Gly Lys Leu Ala Val Val Val Ala Ser Tyr Arg Arg Pro Gly Ala 
65                  70                  75                  80  


Leu Ala Ala Val Pro Ser Pro Leu Glu Leu Cys Asp Asp Ala Asn Pro 
                85                  90                  95      


Val Asp Asn Glu Tyr Phe Phe Asp Arg Ser Ser Gln Ala Phe Arg Tyr 
            100                 105                 110         


Val Leu His Tyr Tyr Arg Thr Gly Arg Leu His Val Met Glu Gln Leu 
        115                 120                 125             


Cys Ala Leu Ser Phe Leu Gln Glu Ile Gln Tyr Trp Gly Ile Asp Glu 
    130                 135                 140                 


Leu Ser Ile Asp Ser Cys Cys Arg Asp Arg Tyr Phe Arg Arg Lys Glu 
145                 150                 155                 160 


Leu Ser Glu Thr Leu Asp Phe Lys Lys Asp Thr Glu Asp Gln Glu Ser 
                165                 170                 175     


Gln His Glu Ser Glu Gln Asp Phe Ser Gln Gly Pro Cys Pro Thr Val 
            180                 185                 190         


Arg Gln Lys Leu Trp Asn Ile Leu Glu Lys Pro Gly Ser Ser Thr Ala 
        195                 200                 205             


Ala Arg Ile Phe Gly Val Ile Ser Ile Ile Phe Val Val Val Ser Ile 
    210                 215                 220                 


Ile Asn Met Ala Leu Met Ser Ala Glu Leu Ser Trp Leu Asp Leu Gln 
225                 230                 235                 240 


Leu Leu Glu Ile Leu Glu Tyr Val Cys Ile Ser Trp Phe Thr Gly Glu 
                245                 250                 255     


Phe Val Leu Arg Phe Leu Cys Val Arg Asp Arg Cys Arg Phe Leu Arg 
            260                 265                 270         


Lys Val Pro Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro Phe Tyr Ile 
        275                 280                 285             


Thr Leu Leu Val Glu Ser Leu Ser Gly Ser Gln Thr Thr Gln Glu Leu 
    290                 295                 300                 


Glu Asn Val Gly Arg Ile Val Gln Val Leu Arg Leu Leu Arg Ala Leu 
305                 310                 315                 320 


Arg Met Leu Lys Leu Gly Arg His Ser Thr Gly Leu Arg Ser Leu Gly 
                325                 330                 335     


Met Thr Ile Thr Gln Cys Tyr Glu Glu Val Gly Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ser Val Gly Ile Ser Ile Phe Ser Thr Val Glu Tyr Phe Ala Glu 
        355                 360                 365             


Gln Ser Ile Pro Asp Thr Thr Phe Thr Ser Val Pro Cys Ala Trp Trp 
    370                 375                 380                 


Trp Ala Thr Thr Ser Met Thr Thr Val Gly Tyr Gly Asp Ile Arg Pro 
385                 390                 395                 400 


Asp Thr Thr Thr Gly Lys Ile Val Ala Phe Met Cys Ile Leu Ser Gly 
                405                 410                 415     


Ile Leu Val Leu Ala Leu Pro Ile Ala Ile Ile Asn Asp Arg Phe Ser 
            420                 425                 430         


Ala Cys Tyr Phe Thr Leu Lys Leu Lys Glu Ala Ala Val Arg Gln Arg 
        435                 440                 445             


Glu Ala Leu Lys Lys Leu Thr Lys Asn Ile Ala Thr Asp Ser Tyr Ile 
    450                 455                 460                 


Ser Val Asn Leu Arg Asp Val Tyr Ala Arg Ser Ile Met Glu Met Leu 
465                 470                 475                 480 


Arg Leu Lys Gly Arg Glu Arg Ala Ser Thr Arg Ser Ser Gly Gly Asp 
                485                 490                 495     


Asp Phe Trp Phe 
            500 


<210>  5789
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCNV2__Homo_sapiens__NP_598004

<400>  5789

Met Leu Lys Gln Ser Glu Arg Arg Arg Ser Trp Ser Tyr Arg Pro Trp 
1               5                   10                  15      


Asn Thr Thr Glu Asn Glu Gly Ser Gln His Arg Arg Ser Ile Cys Ser 
            20                  25                  30          


Leu Gly Ala Arg Ser Gly Ser Gln Ala Ser Ile His Gly Trp Thr Glu 
        35                  40                  45              


Gly Asn Tyr Asn Tyr Tyr Ile Glu Glu Asp Glu Asp Gly Glu Glu Glu 
    50                  55                  60                  


Asp Gln Trp Lys Asp Asp Leu Ala Glu Glu Asp Gln Gln Ala Gly Glu 
65                  70                  75                  80  


Val Thr Thr Ala Lys Pro Glu Gly Pro Ser Asp Pro Pro Ala Leu Leu 
                85                  90                  95      


Ser Thr Leu Asn Val Asn Val Gly Gly His Ser Tyr Gln Leu Asp Tyr 
            100                 105                 110         


Cys Glu Leu Ala Gly Phe Pro Lys Thr Arg Leu Gly Arg Leu Ala Thr 
        115                 120                 125             


Ser Thr Ser Arg Ser Arg Gln Leu Ser Leu Cys Asp Asp Tyr Glu Glu 
    130                 135                 140                 


Gln Thr Asp Glu Tyr Phe Phe Asp Arg Asp Pro Ala Val Phe Gln Leu 
145                 150                 155                 160 


Val Tyr Asn Phe Tyr Leu Ser Gly Val Leu Leu Val Leu Asp Gly Leu 
                165                 170                 175     


Cys Pro Arg Arg Phe Leu Glu Glu Leu Gly Tyr Trp Gly Val Arg Leu 
            180                 185                 190         


Lys Tyr Thr Pro Arg Cys Cys Arg Ile Cys Phe Glu Glu Arg Arg Asp 
        195                 200                 205             


Glu Leu Ser Glu Arg Leu Lys Ile Gln His Glu Leu Arg Ala Gln Ala 
    210                 215                 220                 


Gln Val Glu Glu Ala Glu Glu Leu Phe Arg Asp Met Arg Phe Tyr Gly 
225                 230                 235                 240 


Pro Gln Arg Arg Arg Leu Trp Asn Leu Met Glu Lys Pro Phe Ser Ser 
                245                 250                 255     


Val Ala Ala Lys Ala Ile Gly Val Ala Ser Ser Thr Phe Val Leu Val 
            260                 265                 270         


Ser Val Val Ala Leu Ala Leu Asn Thr Val Glu Glu Met Gln Gln His 
        275                 280                 285             


Ser Gly Gln Gly Glu Gly Gly Pro Asp Leu Arg Pro Ile Leu Glu His 
    290                 295                 300                 


Val Glu Met Leu Cys Met Gly Phe Phe Thr Leu Glu Tyr Leu Leu Arg 
305                 310                 315                 320 


Leu Ala Ser Thr Pro Asp Leu Arg Arg Phe Ala Arg Ser Ala Leu Asn 
                325                 330                 335     


Leu Val Asp Leu Val Ala Ile Leu Pro Leu Tyr Leu Gln Leu Leu Leu 
            340                 345                 350         


Glu Cys Phe Thr Gly Glu Gly His Gln Arg Gly Gln Thr Val Gly Ser 
        355                 360                 365             


Val Gly Lys Val Gly Gln Val Leu Arg Val Met Arg Leu Met Arg Ile 
    370                 375                 380                 


Phe Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ala Phe 
385                 390                 395                 400 


Gly Phe Thr Leu Arg Gln Cys Tyr Gln Gln Val Gly Cys Leu Leu Leu 
                405                 410                 415     


Phe Ile Ala Met Gly Ile Phe Thr Phe Ser Ala Ala Val Tyr Ser Val 
            420                 425                 430         


Glu His Asp Val Pro Ser Thr Asn Phe Thr Thr Ile Pro His Ser Trp 
        435                 440                 445             


Trp Trp Ala Ala Val Ser Ile Ser Thr Val Gly Tyr Gly Asp Met Tyr 
    450                 455                 460                 


Pro Glu Thr His Leu Gly Arg Phe Phe Ala Phe Leu Cys Ile Ala Phe 
465                 470                 475                 480 


Gly Ile Ile Leu Asn Gly Met Pro Ile Ser Ile Leu Tyr Asn Lys Phe 
                485                 490                 495     


Ser Asp Tyr Tyr Ser Lys Leu Lys Ala Tyr Glu Tyr Thr Thr Ile Arg 
            500                 505                 510         


Arg Glu Arg Gly Glu Val Asn Phe Met Gln Arg Ala Arg Lys Lys Ile 
        515                 520                 525             


Ala Glu Cys Leu Leu Gly Ser Asn Pro Gln Leu Thr Pro Arg Gln Glu 
    530                 535                 540                 


Asn 
545 


<210>  5790
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD10__Homo_sapiens__NP_114160

<400>  5790

Met Glu Glu Met Ser Gly Glu Ser Val Val Ser Ser Ala Val Pro Ala 
1               5                   10                  15      


Ala Ala Thr Arg Thr Thr Ser Phe Lys Gly Thr Ser Pro Ser Ser Lys 
            20                  25                  30          


Tyr Val Lys Leu Asn Val Gly Gly Ala Leu Tyr Tyr Thr Thr Met Gln 
        35                  40                  45              


Thr Leu Thr Lys Gln Asp Thr Met Leu Lys Ala Met Phe Ser Gly Arg 
    50                  55                  60                  


Met Glu Val Leu Thr Asp Ser Glu Gly Trp Ile Leu Ile Asp Arg Cys 
65                  70                  75                  80  


Gly Lys His Phe Gly Thr Ile Leu Asn Tyr Leu Arg Asp Gly Ala Val 
                85                  90                  95      


Pro Leu Pro Glu Ser Arg Arg Glu Ile Glu Glu Leu Leu Ala Glu Ala 
            100                 105                 110         


Lys Tyr Tyr Leu Val Gln Gly Leu Val Glu Glu Cys Gln Ala Ala Leu 
        115                 120                 125             


Gln Asn Lys Asp Thr Tyr Glu Pro Phe Cys Lys Val Pro Val Ile Thr 
    130                 135                 140                 


Ser Ser Lys Glu Glu Gln Lys Leu Ile Ala Thr Ser Asn Lys Pro Ala 
145                 150                 155                 160 


Val Lys Leu Leu Tyr Asn Arg Ser Asn Asn Lys Tyr Ser Tyr Thr Ser 
                165                 170                 175     


Asn Ser Asp Asp Asn Met Leu Lys Asn Ile Glu Leu Phe Asp Lys Leu 
            180                 185                 190         


Ser Leu Arg Phe Asn Gly Arg Val Leu Phe Ile Lys Asp Val Ile Gly 
        195                 200                 205             


Asp Glu Ile Cys Cys Trp Ser Phe Tyr Gly Gln Gly Arg Lys Ile Ala 
    210                 215                 220                 


Glu Val Cys Cys Thr Ser Ile Val Tyr Ala Thr Glu Lys Lys Gln Thr 
225                 230                 235                 240 


Lys Val Glu Phe Pro Glu Ala Arg Ile Tyr Glu Glu Thr Leu Asn Ile 
                245                 250                 255     


Leu Leu Tyr Glu Ala Gln Asp Gly Arg Gly Pro Asp Asn Ala Leu Leu 
            260                 265                 270         


Glu Ala Thr Gly Gly Ala Ala Gly Arg Ser His His Leu Asp Glu Asp 
        275                 280                 285             


Glu Glu Arg Glu Arg Ile Glu Arg Val Arg Arg Ile His Ile Lys Arg 
    290                 295                 300                 


Pro Asp Asp Arg Ala His Leu His Gln 
305                 310             


<210>  5791
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD11__Homo_sapiens__NP_001002914

<400>  5791

Met Leu Gly Ala Met Phe Arg Ala Gly Thr Pro Met Pro Pro Asn Leu 
1               5                   10                  15      


Asn Ser Gln Gly Gly Gly His Tyr Phe Ile Asp Arg Asp Gly Lys Ala 
            20                  25                  30          


Phe Arg His Ile Leu Asn Phe Leu Arg Leu Gly Arg Leu Asp Leu Pro 
        35                  40                  45              


Arg Gly Tyr Gly Glu Thr Ala Leu Leu Arg Ala Glu Ala Asp Phe Tyr 
    50                  55                  60                  


Gln Ile Arg Pro Leu Leu Asp Ala Leu Arg Glu Leu Glu Ala Ser Gln 
65                  70                  75                  80  


Gly Thr Pro Ala Pro Thr Ala Ala Leu Leu His Ala Asp Val Asp Val 
                85                  90                  95      


Ser Pro Arg Leu Val His Phe Ser Ala Arg Arg Gly Pro His His Tyr 
            100                 105                 110         


Glu Leu Ser Ser Val Gln Val Asp Thr Phe Arg Ala Asn Leu Phe Cys 
        115                 120                 125             


Thr Asp Ser Glu Cys Leu Gly Ala Leu Arg Ala Arg Phe Gly Val Ala 
    130                 135                 140                 


Ser Gly Asp Arg Ala Glu Gly Ser Pro His Phe His Leu Glu Trp Ala 
145                 150                 155                 160 


Pro Arg Pro Val Glu Leu Pro Glu Val Glu Tyr Gly Arg Leu Gly Leu 
                165                 170                 175     


Gln Pro Leu Trp Thr Gly Gly Pro Gly Glu Arg Arg Glu Val Val Gly 
            180                 185                 190         


Thr Pro Ser Phe Leu Glu Glu Val Leu Arg Val Ala Leu Glu His Gly 
        195                 200                 205             


Phe Arg Leu Asp Ser Val Phe Pro Asp Pro Glu Asp Leu Leu Asn Ser 
    210                 215                 220                 


Arg Ser Leu Arg Phe Val Arg His 
225                 230         


<210>  5792
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD12__Homo_sapiens__NP_612453

<400>  5792

Met Ala Leu Ala Asp Ser Thr Arg Gly Leu Pro Asn Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Ser Ser Ser Ser Ser Ala Glu Pro Pro Leu Phe 
            20                  25                  30          


Pro Asp Ile Val Glu Leu Asn Val Gly Gly Gln Val Tyr Val Thr Arg 
        35                  40                  45              


Arg Cys Thr Val Val Ser Val Pro Asp Ser Leu Leu Trp Arg Met Phe 
    50                  55                  60                  


Thr Gln Gln Gln Pro Gln Glu Leu Ala Arg Asp Ser Lys Gly Arg Phe 
65                  70                  75                  80  


Phe Leu Asp Arg Asp Gly Phe Leu Phe Arg Tyr Ile Leu Asp Tyr Leu 
                85                  90                  95      


Arg Asp Leu Gln Leu Val Leu Pro Asp Tyr Phe Pro Glu Arg Ser Arg 
            100                 105                 110         


Leu Gln Arg Glu Ala Glu Tyr Phe Glu Leu Pro Glu Leu Val Arg Arg 
        115                 120                 125             


Leu Gly Ala Pro Gln Gln Pro Gly Pro Gly Pro Pro Pro Ser Arg Arg 
    130                 135                 140                 


Gly Val His Lys Glu Gly Ser Leu Gly Asp Glu Leu Leu Pro Leu Gly 
145                 150                 155                 160 


Tyr Ser Glu Pro Glu Gln Gln Glu Gly Ala Ser Ala Gly Ala Pro Ser 
                165                 170                 175     


Pro Thr Leu Glu Leu Ala Ser Arg Ser Pro Ser Gly Gly Ala Ala Gly 
            180                 185                 190         


Pro Leu Leu Thr Pro Ser Gln Ser Leu Asp Gly Ser Arg Arg Ser Gly 
        195                 200                 205             


Tyr Ile Thr Ile Gly Tyr Arg Gly Ser Tyr Thr Ile Gly Arg Asp Ala 
    210                 215                 220                 


Gln Ala Asp Ala Lys Phe Arg Arg Val Ala Arg Ile Thr Val Cys Gly 
225                 230                 235                 240 


Lys Thr Ser Leu Ala Lys Glu Val Phe Gly Asp Thr Leu Asn Glu Ser 
                245                 250                 255     


Arg Asp Pro Asp Arg Pro Pro Glu Arg Tyr Thr Ser Arg Tyr Tyr Leu 
            260                 265                 270         


Lys Phe Asn Phe Leu Glu Gln Ala Phe Asp Lys Leu Ser Glu Ser Gly 
        275                 280                 285             


Phe His Met Val Ala Cys Ser Ser Thr Gly Thr Cys Ala Phe Ala Ser 
    290                 295                 300                 


Ser Thr Asp Gln Ser Glu Asp Lys Ile Trp Thr Ser Tyr Thr Glu Tyr 
305                 310                 315                 320 


Val Phe Cys Arg Glu 
                325 


<210>  5793
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD13__Homo_sapiens__NP_849194

<400>  5793

Met Ser Ala Glu Ala Ser Gly Pro Ala Ala Ala Ala Ala Pro Ser Leu 
1               5                   10                  15      


Glu Ala Pro Lys Pro Ser Gly Leu Glu Pro Gly Pro Ala Ala Tyr Gly 
            20                  25                  30          


Leu Lys Pro Leu Thr Pro Asn Ser Lys Tyr Val Lys Leu Asn Val Gly 
        35                  40                  45              


Gly Ser Leu His Tyr Thr Thr Leu Arg Thr Leu Thr Gly Gln Asp Thr 
    50                  55                  60                  


Met Leu Lys Ala Met Phe Ser Gly Arg Val Glu Val Leu Thr Asp Ala 
65                  70                  75                  80  


Gly Gly Trp Val Leu Ile Asp Arg Ser Gly Arg His Phe Gly Thr Ile 
                85                  90                  95      


Leu Asn Tyr Leu Arg Asp Gly Ser Val Pro Leu Pro Glu Ser Thr Arg 
            100                 105                 110         


Glu Leu Gly Glu Leu Leu Gly Glu Ala Arg Tyr Tyr Leu Val Gln Gly 
        115                 120                 125             


Leu Ile Glu Asp Cys Gln Leu Ala Leu Gln Gln Lys Arg Glu Thr Leu 
    130                 135                 140                 


Ser Pro Leu Cys Leu Ile Pro Met Val Thr Ser Pro Arg Glu Glu Gln 
145                 150                 155                 160 


Gln Leu Leu Ala Ser Thr Ser Lys Pro Val Val Lys Leu Leu His Asn 
                165                 170                 175     


Arg Ser Asn Asn Lys Tyr Ser Tyr Thr Ser Thr Ser Asp Asp Asn Leu 
            180                 185                 190         


Leu Lys Asn Ile Glu Leu Phe Asp Lys Leu Ala Leu Arg Phe His Gly 
        195                 200                 205             


Arg Leu Leu Phe Leu Lys Asp Val Leu Gly Asp Glu Ile Cys Cys Trp 
    210                 215                 220                 


Ser Phe Tyr Gly Gln Gly Arg Lys Ile Ala Glu Val Cys Cys Thr Ser 
225                 230                 235                 240 


Ile Val Tyr Ala Thr Glu Lys Lys Gln Thr Lys Val Glu Phe Pro Glu 
                245                 250                 255     


Ala Arg Ile Phe Glu Glu Thr Leu Asn Ile Leu Ile Tyr Glu Thr Pro 
            260                 265                 270         


Arg Gly Pro Asp Pro Ala Leu Leu Glu Ala Thr Gly Gly Ala Ala Gly 
        275                 280                 285             


Ala Gly Gly Ala Gly Arg Gly Glu Asp Glu Glu Asn Arg Glu His Arg 
    290                 295                 300                 


Val Arg Arg Ile His Val Arg Arg His Ile Thr His Asp Glu Arg Pro 
305                 310                 315                 320 


His Gly Gln Gln Ile Val Phe Lys Asp 
                325                 


<210>  5794
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD15__Homo_sapiens__NP_076981

<400>  5794

Met Pro His Arg Lys Glu Arg Pro Ser Gly Ser Ser Leu His Thr His 
1               5                   10                  15      


Gly Ser Thr Gly Thr Ala Glu Gly Gly Asn Met Ser Arg Leu Ser Leu 
            20                  25                  30          


Thr Arg Ser Pro Val Ser Pro Leu Ala Ala Gln Gly Ile Pro Leu Pro 
        35                  40                  45              


Ala Gln Leu Thr Lys Ser Asn Ala Pro Val His Ile Asp Val Gly Gly 
    50                  55                  60                  


His Met Tyr Thr Ser Ser Leu Ala Thr Leu Thr Lys Tyr Pro Asp Ser 
65                  70                  75                  80  


Arg Ile Ser Arg Leu Phe Asn Gly Thr Glu Pro Ile Val Leu Asp Ser 
                85                  90                  95      


Leu Lys Gln His Tyr Phe Ile Asp Arg Asp Gly Glu Ile Phe Arg Tyr 
            100                 105                 110         


Val Leu Ser Phe Leu Arg Thr Ser Lys Leu Leu Leu Pro Asp Asp Phe 
        115                 120                 125             


Lys Asp Phe Ser Leu Leu Tyr Glu Glu Ala Arg Tyr Tyr Gln Leu Gln 
    130                 135                 140                 


Pro Met Val Arg Glu Leu Glu Arg Trp Gln Gln Glu Gln Glu Gln Arg 
145                 150                 155                 160 


Arg Arg Ser Arg Ala Cys Asp Cys Leu Val Val Arg Val Thr Pro Asp 
                165                 170                 175     


Leu Gly Glu Arg Ile Ala Leu Ser Gly Glu Lys Ala Leu Ile Glu Glu 
            180                 185                 190         


Val Phe Pro Glu Thr Gly Asp Val Met Cys Asn Ser Val Asn Ala Gly 
        195                 200                 205             


Trp Asn Gln Asp Pro Thr His Val Ile Arg Phe Pro Leu Asn Gly Tyr 
    210                 215                 220                 


Cys Arg Leu Asn Ser Val Gln Asp Val Leu 
225                 230                 


<210>  5795
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD16__Homo_sapiens__XP_005268550

<400>  5795

Met Ala Leu Ser Gly Asn Cys Ser Arg Tyr Tyr Pro Arg Glu Gln Gly 
1               5                   10                  15      


Ser Ala Val Pro Asn Ser Phe Pro Glu Val Val Glu Leu Asn Val Gly 
            20                  25                  30          


Gly Gln Val Tyr Phe Thr Arg His Ser Thr Leu Ile Ser Ile Pro His 
        35                  40                  45              


Ser Leu Leu Trp Lys Met Phe Ser Pro Lys Arg Asp Thr Ala Asn Asp 
    50                  55                  60                  


Leu Ala Lys Asp Ser Lys Gly Arg Phe Phe Ile Asp Arg Asp Gly Phe 
65                  70                  75                  80  


Leu Phe Arg Tyr Ile Leu Asp Tyr Leu Arg Asp Arg Gln Val Val Leu 
                85                  90                  95      


Pro Asp His Phe Pro Glu Lys Gly Arg Leu Lys Arg Glu Ala Glu Tyr 
            100                 105                 110         


Phe Gln Leu Pro Asp Leu Val Lys Leu Leu Thr Pro Asp Glu Ile Lys 
        115                 120                 125             


Gln Ser Pro Asp Glu Phe Cys His Ser Asp Phe Glu Asp Ala Ser Gln 
    130                 135                 140                 


Gly Ser Asp Thr Arg Ile Cys Pro Pro Ser Ser Leu Leu Pro Ala Asp 
145                 150                 155                 160 


Arg Lys Trp Gly Phe Ile Thr Val Gly Tyr Arg Gly Ser Cys Thr Leu 
                165                 170                 175     


Gly Arg Glu Gly Gln Ala Asp Ala Lys Phe Arg Arg Val Pro Arg Ile 
            180                 185                 190         


Leu Val Cys Gly Arg Ile Ser Leu Ala Lys Glu Val Phe Gly Glu Thr 
        195                 200                 205             


Leu Asn Glu Ser Arg Asp Pro Asp Arg Ala Pro Glu Arg Tyr Thr Ser 
    210                 215                 220                 


Arg Phe Tyr Leu Lys Phe Lys His Leu Glu Arg Ala Phe Asp Met Leu 
225                 230                 235                 240 


Ser Glu Cys Gly Phe His Met Val Ala Cys Asn Ser Ser Val Thr Ala 
                245                 250                 255     


Ser Phe Ile Asn Gln Tyr Thr Asp Asp Lys Ile Trp Ser Ser Tyr Thr 
            260                 265                 270         


Glu Tyr Val Phe Tyr Arg Glu Pro Ser Arg Trp Ser Pro Ser His Cys 
        275                 280                 285             


Asp Cys Cys Cys Lys Asn Gly Lys Gly Asp Lys Glu Gly Glu Ser Gly 
    290                 295                 300                 


Thr Ser Cys Asn Asp Leu Ser Thr Ser Ser Cys Asp Ser Gln Ser Glu 
305                 310                 315                 320 


Ala Ser Ser Pro Gln Glu Thr Val Ile Cys Gly Pro Val Thr Arg Gln 
                325                 330                 335     


Thr Asn Ile Gln Thr Leu Asp Arg Pro Ile Lys Lys Gly Pro Val Gln 
            340                 345                 350         


Leu Ile Gln Gln Ser Glu Met Arg Arg Lys Ser Asp Leu Leu Arg Thr 
        355                 360                 365             


Leu Thr Ser Gly Ser Arg Glu Ser Asn Met Ser Ser Lys Lys Lys Ala 
    370                 375                 380                 


Val Lys Glu Lys Leu Ser Ile Glu Glu Glu Leu Glu Lys Cys Ile Gln 
385                 390                 395                 400 


Asp Phe Leu Lys Ile Lys Ile Pro Asp Arg Phe Pro Glu Arg Lys His 
                405                 410                 415     


Pro Trp Gln Ser Glu Leu Leu Arg Lys Tyr His Leu 
            420                 425             


<210>  5796
<211>  865
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD1__Homo_sapiens__NP_001136202

<400>  5796

Met Ala Arg Met Pro Gly Ser Gly Asp Cys Asn Thr Ser Ala Gly Gly 
1               5                   10                  15      


Ser Ala Ser Ala Ala Ala Ala Ala Ala Glu Asn Asn Gly Glu Arg Gly 
            20                  25                  30          


Glu Gly Glu Arg Gly Ala Gly Gly Arg Gly Arg Arg His Ser Arg Pro 
        35                  40                  45              


His Tyr Cys Ser Ala Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    50                  55                  60                  


Glu Ile Gln Glu Val Gln Ile Thr Gly Asp Glu Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Gly Gly Gly Gly Leu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Met Gly Leu Asp Trp Asp Glu Pro Leu Glu Pro Glu Asp Ser Ala Gly 
            100                 105                 110         


Glu Glu Leu Glu Pro Glu Pro Val His Met Ile Asn Met Asp Gln Ser 
        115                 120                 125             


Ala Ala Leu Glu Pro Glu Ala Pro Pro Arg Leu Leu Ala Pro Arg Ala 
    130                 135                 140                 


Arg Gly Gly Pro Pro Gly Asp Gly Ser Glu Leu Asp Pro Asp Val Leu 
145                 150                 155                 160 


Gln Arg Pro Glu Arg Ala Arg Leu Ser Glu Asn Thr Arg Leu Ala Thr 
                165                 170                 175     


Arg Tyr Ala Val Arg Ile Phe Arg Glu Tyr Leu Ser Glu Lys Ala Gln 
            180                 185                 190         


Ser Pro Asp Phe Glu Thr Met Asp Lys Gly Ala Leu Cys Arg Val Leu 
        195                 200                 205             


Arg Ser Phe Tyr Ala Glu Ala Arg Ser Lys Ser Gly Gln Leu Tyr Ser 
    210                 215                 220                 


Lys Ser Ser Leu Ile Ser Ile Arg Ser Ser Leu Asn Arg Tyr Leu Asn 
225                 230                 235                 240 


Glu Pro Pro Tyr Cys Arg Thr Leu Asp Leu Thr Lys Asp Pro Glu Leu 
                245                 250                 255     


Arg Ser Ala Asn Leu Thr Leu Ala Ala Val Ile Arg Lys Leu Glu Glu 
            260                 265                 270         


Gln Gly Ala Gly Pro Val Val Gln Lys Gln Ala Ile Thr Arg Ala Asp 
        275                 280                 285             


Leu Arg Lys Leu Tyr Thr Ser Ser Val Phe Ser Thr Asn Thr Pro Phe 
    290                 295                 300                 


Gly Leu Leu Asn Lys Val Trp Phe Glu Thr Cys Met Tyr Phe Cys Thr 
305                 310                 315                 320 


Arg Gly Arg Glu Asn Gln Arg Glu Leu Glu Glu Asp Ser Phe Gly Leu 
                325                 330                 335     


Ala Met Asp Glu Asp Gly Arg Lys Phe Val Tyr Phe Lys Ser Leu Gly 
            340                 345                 350         


Pro Tyr His Lys Ser Arg Ser Ser Ser Trp Ser Lys Lys Arg Ala Glu 
        355                 360                 365             


Ser Ser Asp Glu Glu Asn Leu Pro Arg Met Tyr Glu Thr Gly Thr Glu 
    370                 375                 380                 


Phe Cys Pro Tyr Ala Ser Phe Val Lys Tyr Leu Ser Lys Arg Asn Pro 
385                 390                 395                 400 


Leu Cys Lys Ala Phe Phe Gln Arg Pro Arg Asp His Cys Ser Glu Gly 
                405                 410                 415     


Asp Val Thr Trp Tyr Glu Asn Lys Ala Ile Gly Lys Asn Leu Leu Gly 
            420                 425                 430         


Thr Arg Met Gln Met Leu Ser Lys Ala Ala Lys Leu Ser Lys Thr Tyr 
        435                 440                 445             


Thr Asn His Cys Ile Gly Ala Val Ser Ile Ala Thr Leu Asn Ser Ile 
    450                 455                 460                 


Ala Gly Ile Gly Thr Lys Leu Gly Ser Pro Ala Pro Gln Gly Cys Tyr 
465                 470                 475                 480 


Ala Glu Ala Leu Asn Gly Ala Ala Arg His His Ser His His Pro Pro 
                485                 490                 495     


Thr His Pro Ser His His His Arg Pro Gln Pro Pro Ser Leu Gly Asn 
            500                 505                 510         


Thr Tyr Ile Leu Pro Lys Asp Ser Gln Val Gly Pro Asp Val Lys Ser 
        515                 520                 525             


Glu Ala Ala Pro Lys Arg Ala Leu Tyr Glu Ser Val Phe Gly Ser Gly 
    530                 535                 540                 


Glu Ile Cys Gly Pro Thr Ser Pro Lys Arg Leu Cys Ile Arg Pro Ser 
545                 550                 555                 560 


Glu Pro Val Asp Ala Val Val Val Val Ser Val Lys His Asp Pro Leu 
                565                 570                 575     


Pro Leu Leu Pro Glu Ala Asn Gly His Arg Ser Thr Asn Ser Pro Thr 
            580                 585                 590         


Ile Val Ser Pro Ala Ile Val Ser Pro Thr Gln Asp Ser Arg Pro Asn 
        595                 600                 605             


Met Ser Arg Pro Leu Ile Thr Arg Ser Pro Ala Ser Pro Leu Asn Asn 
    610                 615                 620                 


Gln Gly Ile Pro Thr Pro Ala Gln Leu Thr Lys Ser Asn Ala Pro Val 
625                 630                 635                 640 


His Ile Asp Val Gly Gly His Met Tyr Thr Ser Ser Leu Ala Thr Leu 
                645                 650                 655     


Thr Lys Tyr Pro Glu Ser Arg Ile Gly Arg Leu Phe Asp Gly Thr Glu 
            660                 665                 670         


Pro Ile Val Leu Asp Ser Leu Lys Gln His Tyr Phe Ile Asp Arg Asp 
        675                 680                 685             


Gly Gln Met Phe Arg Tyr Ile Leu Asn Phe Leu Arg Thr Ser Lys Leu 
    690                 695                 700                 


Leu Ile Pro Asp Asp Phe Lys Asp Tyr Thr Leu Leu Tyr Glu Glu Ala 
705                 710                 715                 720 


Lys Tyr Phe Gln Leu Gln Pro Met Leu Leu Glu Met Glu Arg Trp Lys 
                725                 730                 735     


Gln Asp Arg Glu Thr Gly Arg Phe Ser Arg Pro Cys Glu Cys Leu Val 
            740                 745                 750         


Val Arg Val Ala Pro Asp Leu Gly Glu Arg Ile Thr Leu Ser Gly Asp 
        755                 760                 765             


Lys Ser Leu Ile Glu Glu Val Phe Pro Glu Ile Gly Asp Val Met Cys 
    770                 775                 780                 


Asn Ser Val Asn Ala Gly Trp Asn His Asp Ser Thr His Val Ile Arg 
785                 790                 795                 800 


Phe Pro Leu Asn Gly Tyr Cys His Leu Asn Ser Val Gln Val Leu Glu 
                805                 810                 815     


Arg Leu Gln Gln Arg Gly Phe Glu Ile Val Gly Ser Cys Gly Gly Gly 
            820                 825                 830         


Val Asp Ser Ser Gln Phe Ser Glu Tyr Val Leu Arg Arg Glu Leu Arg 
        835                 840                 845             


Arg Thr Pro Arg Val Pro Ser Val Ile Arg Ile Lys Gln Glu Pro Leu 
    850                 855                 860                 


Asp 
865 


<210>  5797
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD21__Homo_sapiens__XP_005273982

<400>  5797

Met Glu Phe Ala Leu Asp Ala Pro Ser Cys Glu Glu Pro Arg Glu Asn 
1               5                   10                  15      


Tyr Gln Ser Arg Lys Ala Ala His Arg Pro Arg Thr Ala Thr Pro Leu 
            20                  25                  30          


Gly Trp Ala Pro Thr Leu Arg Pro Pro Arg Lys Ala Ala Leu Ala Ala 
        35                  40                  45              


Arg Gly Gly Arg Gly Cys Arg Ala Arg Ala Gly Gly Leu Leu Pro Ala 
    50                  55                  60                  


Thr Gln Ser Pro Ala Met Ser Asp Pro Ile Thr Leu Asn Val Gly Gly 
65                  70                  75                  80  


Lys Leu Tyr Thr Thr Ser Leu Ala Thr Leu Thr Ser Phe Pro Asp Ser 
                85                  90                  95      


Met Leu Gly Ala Met Phe Ser Gly Lys Met Pro Thr Lys Arg Asp Ser 
            100                 105                 110         


Gln Gly Asn Cys Phe Ile Asp Arg Asp Gly Lys Val Phe Arg Tyr Ile 
        115                 120                 125             


Leu Asn Phe Leu Arg Thr Ser His Leu Asp Leu Pro Glu Asp Phe Gln 
    130                 135                 140                 


Glu Met Gly Leu Leu Arg Arg Glu Ala Asp Phe Tyr Gln Val Gln Pro 
145                 150                 155                 160 


Leu Ile Glu Ala Leu Gln Glu Lys Glu Val Glu Leu Ser Lys Ala Glu 
                165                 170                 175     


Lys Asn Ala Met Leu Asn Ile Thr Leu Asn Gln Arg Val Gln Thr Val 
            180                 185                 190         


His Phe Thr Val Arg Glu Ala Pro Gln Ile Tyr Ser Leu Ser Ser Ser 
        195                 200                 205             


Ser Met Glu Val Phe Asn Ala Asn Ile Phe Ser Thr Ser Cys Leu Phe 
    210                 215                 220                 


Leu Lys Leu Leu Gly Ser Lys Leu Phe Tyr Cys Ser Asn Gly Asn Leu 
225                 230                 235                 240 


Ser Ser Ile Thr Ser His Leu Gln Asp Pro Asn His Leu Thr Leu Asp 
                245                 250                 255     


Trp Val Ala Asn Val Glu Gly Leu Pro Glu Glu Glu Tyr Thr Lys Gln 
            260                 265                 270         


Asn Leu Lys Arg Leu Trp Val Val Pro Ala Asn Lys Gln Ile Asn Ser 
        275                 280                 285             


Phe Gln Val Phe Val Glu Glu Val Leu Lys Ile Ala Leu Ser Asp Gly 
    290                 295                 300                 


Phe Cys Ile Asp Ser Ser His Pro His Ala Leu Asp Phe Met Asn Asn 
305                 310                 315                 320 


Lys Ile Ile Arg Leu Ile Arg Tyr Arg 
                325                 


<210>  5798
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD2__Homo_sapiens__NP_056168

<400>  5798

Met Ala Glu Leu Gln Leu Asp Pro Ala Met Ala Gly Leu Gly Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Val Gly Asp Gly Gly Gly Pro Val Arg Gly Pro Pro 
            20                  25                  30          


Ser Pro Arg Pro Ala Gly Pro Thr Pro Arg Gly His Gly Arg Pro Ala 
        35                  40                  45              


Ala Ala Val Ala Gln Pro Leu Glu Pro Gly Pro Gly Pro Pro Glu Arg 
    50                  55                  60                  


Ala Gly Gly Gly Gly Ala Ala Arg Trp Val Arg Leu Asn Val Gly Gly 
65                  70                  75                  80  


Thr Tyr Phe Val Thr Thr Arg Gln Thr Leu Gly Arg Glu Pro Lys Ser 
                85                  90                  95      


Phe Leu Cys Arg Leu Cys Cys Gln Glu Asp Pro Glu Leu Asp Ser Asp 
            100                 105                 110         


Lys Asp Glu Thr Gly Ala Tyr Leu Ile Asp Arg Asp Pro Thr Tyr Phe 
        115                 120                 125             


Gly Pro Ile Leu Asn Tyr Leu Arg His Gly Lys Leu Ile Ile Thr Lys 
    130                 135                 140                 


Glu Leu Ala Glu Glu Gly Val Leu Glu Glu Ala Glu Phe Tyr Asn Ile 
145                 150                 155                 160 


Ala Ser Leu Val Arg Leu Val Lys Glu Arg Ile Arg Asp Asn Glu Asn 
                165                 170                 175     


Arg Thr Ser Gln Gly Pro Val Lys His Val Tyr Arg Val Leu Gln Cys 
            180                 185                 190         


Gln Glu Glu Glu Leu Thr Gln Met Val Ser Thr Met Ser Asp Gly Trp 
        195                 200                 205             


Lys Phe Glu Gln Leu Ile Ser Ile Gly Ser Ser Tyr Asn Tyr Gly Asn 
    210                 215                 220                 


Glu Asp Gln Ala Glu Phe Leu Cys Val Val Ser Arg Glu Leu Asn Asn 
225                 230                 235                 240 


Ser Thr Asn Gly Ile Val Ile Glu Pro Ser Glu Lys Ala Lys Ile Leu 
                245                 250                 255     


Gln Glu Arg Gly Ser Arg Met 
            260             


<210>  5799
<211>  815
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD3__Homo_sapiens__NP_057205

<400>  5799

Met Ala Gly Gly His Cys Gly Ser Phe Pro Ala Ala Ala Ala Gly Ser 
1               5                   10                  15      


Gly Glu Ile Val Gln Leu Asn Val Gly Gly Thr Arg Phe Ser Thr Ser 
            20                  25                  30          


Arg Gln Thr Leu Met Trp Ile Pro Asp Ser Phe Phe Ser Ser Leu Leu 
        35                  40                  45              


Ser Gly Arg Ile Ser Thr Leu Arg Asp Glu Thr Gly Ala Ile Phe Ile 
    50                  55                  60                  


Asp Arg Asp Pro Ala Ala Phe Ala Pro Ile Leu Asn Phe Leu Arg Thr 
65                  70                  75                  80  


Lys Glu Leu Asp Leu Arg Gly Val Ser Ile Asn Val Leu Arg His Glu 
                85                  90                  95      


Ala Glu Phe Tyr Gly Ile Thr Pro Leu Val Arg Arg Leu Leu Leu Cys 
            100                 105                 110         


Glu Glu Leu Glu Arg Ser Ser Cys Gly Ser Val Leu Phe His Gly Tyr 
        115                 120                 125             


Leu Pro Pro Pro Gly Ile Pro Ser Arg Lys Ile Asn Asn Thr Val Arg 
    130                 135                 140                 


Ser Ala Asp Ser Arg Asn Gly Leu Asn Ser Thr Glu Gly Glu Ala Arg 
145                 150                 155                 160 


Gly Asn Gly Thr Gln Pro Val Leu Ser Gly Thr Gly Glu Glu Thr Val 
                165                 170                 175     


Arg Leu Gly Phe Pro Val Asp Pro Arg Lys Val Leu Ile Val Ala Gly 
            180                 185                 190         


His His Asn Trp Ile Val Ala Ala Tyr Ala His Phe Ala Val Cys Tyr 
        195                 200                 205             


Arg Ile Lys Glu Ser Ser Gly Trp Gln Gln Val Phe Thr Ser Pro Tyr 
    210                 215                 220                 


Leu Asp Trp Thr Ile Glu Arg Val Ala Leu Asn Ala Lys Val Val Gly 
225                 230                 235                 240 


Gly Pro His Gly Asp Lys Asp Lys Met Val Ala Val Ala Ser Glu Ser 
                245                 250                 255     


Ser Ile Ile Leu Trp Ser Val Gln Asp Gly Gly Ser Gly Ser Glu Ile 
            260                 265                 270         


Gly Val Phe Ser Leu Gly Val Pro Val Asp Ala Leu Phe Phe Ile Gly 
        275                 280                 285             


Asn Gln Leu Val Ala Thr Ser His Thr Gly Lys Val Gly Val Trp Asn 
    290                 295                 300                 


Ala Val Thr Gln His Trp Gln Val Gln Asp Val Val Pro Ile Thr Ser 
305                 310                 315                 320 


Tyr Asp Thr Ala Gly Ser Phe Leu Leu Leu Gly Cys Asn Asn Gly Ser 
                325                 330                 335     


Ile Tyr Tyr Ile Asp Met Gln Lys Phe Pro Leu Arg Met Lys Asp Asn 
            340                 345                 350         


Asp Leu Leu Val Thr Glu Leu Tyr His Asp Pro Ser Asn Asp Ala Ile 
        355                 360                 365             


Thr Ala Leu Ser Val Tyr Leu Thr Pro Lys Thr Ser Val Ser Gly Asn 
    370                 375                 380                 


Trp Ile Glu Ile Ala Tyr Gly Thr Ser Ser Gly Ala Val Arg Val Ile 
385                 390                 395                 400 


Val Gln His Pro Glu Thr Val Gly Ser Gly Pro Gln Leu Phe Gln Thr 
                405                 410                 415     


Phe Thr Val His Arg Ser Pro Val Thr Lys Ile Met Leu Ser Glu Lys 
            420                 425                 430         


His Leu Val Ser Val Cys Ala Asp Asn Asn His Val Arg Thr Trp Thr 
        435                 440                 445             


Val Thr Arg Phe Arg Gly Met Ile Ser Thr Gln Pro Gly Ser Thr Pro 
    450                 455                 460                 


Leu Ala Ser Phe Lys Ile Leu Ser Leu Glu Glu Thr Glu Ser His Gly 
465                 470                 475                 480 


Ser Tyr Ser Ser Gly Asn Asp Ile Gly Pro Phe Gly Glu Arg Asp Asp 
                485                 490                 495     


Gln Gln Val Phe Ile Gln Lys Val Val Pro Ile Thr Asn Lys Leu Phe 
            500                 505                 510         


Val Arg Leu Ser Ser Thr Gly Lys Arg Ile Cys Glu Ile Gln Ala Val 
        515                 520                 525             


Asp Cys Thr Thr Ile Ser Ser Phe Thr Val Arg Glu Cys Glu Gly Ser 
    530                 535                 540                 


Ser Arg Met Gly Ser Arg Pro Arg Arg Tyr Leu Phe Thr Gly His Thr 
545                 550                 555                 560 


Asn Gly Ser Ile Gln Met Trp Asp Leu Thr Thr Ala Met Asp Met Val 
                565                 570                 575     


Asn Lys Ser Glu Asp Lys Asp Val Gly Gly Pro Thr Glu Glu Glu Leu 
            580                 585                 590         


Leu Lys Leu Leu Asp Gln Cys Asp Leu Ser Thr Ser Arg Cys Ala Thr 
        595                 600                 605             


Pro Asn Ile Ser Pro Ala Thr Ser Val Val Gln His Ser His Leu Arg 
    610                 615                 620                 


Glu Ser Asn Ser Ser Leu Gln Leu Gln His His Asp Thr Thr His Glu 
625                 630                 635                 640 


Ala Ala Thr Tyr Gly Ser Met Arg Pro Tyr Arg Glu Ser Pro Leu Leu 
                645                 650                 655     


Ala Arg Ala Arg Arg Thr Glu Ser Phe His Ser Tyr Arg Asp Phe Gln 
            660                 665                 670         


Thr Ile Asn Leu Asn Arg Asn Val Glu Arg Ala Val Pro Glu Asn Gly 
        675                 680                 685             


Asn Leu Gly Pro Ile Gln Ala Glu Val Lys Gly Ala Thr Gly Glu Cys 
    690                 695                 700                 


Asn Ile Ser Glu Arg Lys Ser Pro Gly Val Glu Ile Lys Ser Leu Arg 
705                 710                 715                 720 


Glu Leu Asp Ser Gly Leu Glu Val His Lys Ile Ala Glu Gly Phe Ser 
                725                 730                 735     


Glu Ser Lys Lys Arg Ser Ser Glu Asp Glu Asn Glu Asn Lys Ile Glu 
            740                 745                 750         


Phe Arg Lys Lys Gly Gly Phe Glu Gly Gly Gly Phe Leu Gly Arg Lys 
        755                 760                 765             


Lys Val Pro Tyr Leu Ala Ser Ser Pro Ser Thr Ser Asp Gly Gly Thr 
    770                 775                 780                 


Asp Ser Pro Gly Thr Ala Ser Pro Ser Pro Thr Lys Thr Thr Pro Ser 
785                 790                 795                 800 


Pro Arg His Lys Lys Ser Asp Ser Ser Gly Gln Glu Tyr Ser Leu 
                805                 810                 815 


<210>  5800
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD6__Homo_sapiens__NP_699162

<400>  5800

Met Asp Asn Gly Asp Trp Gly Tyr Met Met Thr Asp Pro Val Thr Leu 
1               5                   10                  15      


Asn Val Gly Gly His Leu Tyr Thr Thr Ser Leu Thr Thr Leu Thr Arg 
            20                  25                  30          


Tyr Pro Asp Ser Met Leu Gly Ala Met Phe Gly Gly Asp Phe Pro Thr 
        35                  40                  45              


Ala Arg Asp Pro Gln Gly Asn Tyr Phe Ile Asp Arg Asp Gly Pro Leu 
    50                  55                  60                  


Phe Arg Tyr Val Leu Asn Phe Leu Arg Thr Ser Glu Leu Thr Leu Pro 
65                  70                  75                  80  


Leu Asp Phe Lys Glu Phe Asp Leu Leu Arg Lys Glu Ala Asp Phe Tyr 
                85                  90                  95      


Gln Ile Glu Pro Leu Ile Gln Cys Leu Asn Asp Pro Lys Pro Leu Tyr 
            100                 105                 110         


Pro Met Asp Thr Phe Glu Glu Val Val Glu Leu Ser Ser Thr Arg Lys 
        115                 120                 125             


Leu Ser Lys Tyr Ser Asn Pro Val Ala Val Ile Ile Thr Gln Leu Thr 
    130                 135                 140                 


Ile Thr Thr Lys Val His Ser Leu Leu Glu Gly Ile Ser Asn Tyr Phe 
145                 150                 155                 160 


Thr Lys Trp Asn Lys His Met Met Asp Thr Arg Asp Cys Gln Val Ser 
                165                 170                 175     


Phe Thr Phe Gly Pro Cys Asp Tyr His Gln Glu Val Ser Leu Arg Val 
            180                 185                 190         


His Leu Met Glu Tyr Ile Thr Lys Gln Gly Phe Thr Ile Arg Asn Thr 
        195                 200                 205             


Arg Val His His Met Ser Glu Arg Ala Asn Glu Asn Thr Val Glu His 
    210                 215                 220                 


Asn Trp Thr Phe Cys Arg Leu Ala Arg Lys Thr Asp Asp 
225                 230                 235         


<210>  5801
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD7__Homo_sapiens__NP_001161433

<400>  5801

Met Val Val Val Thr Gly Arg Glu Pro Asp Ser Arg Arg Gln Asp Gly 
1               5                   10                  15      


Ala Met Ser Ser Ser Asp Ala Glu Asp Asp Phe Leu Glu Pro Ala Thr 
            20                  25                  30          


Pro Thr Ala Thr Gln Ala Gly His Ala Leu Pro Leu Leu Pro Gln Glu 
        35                  40                  45              


Phe Pro Glu Val Val Pro Leu Asn Ile Gly Gly Ala His Phe Thr Thr 
    50                  55                  60                  


Arg Leu Ser Thr Leu Arg Cys Tyr Glu Asp Thr Met Leu Ala Ala Met 
65                  70                  75                  80  


Phe Ser Gly Arg His Tyr Ile Pro Thr Asp Ser Glu Gly Arg Tyr Phe 
                85                  90                  95      


Ile Asp Arg Asp Gly Thr His Phe Gly Asp Val Leu Asn Phe Leu Arg 
            100                 105                 110         


Ser Gly Asp Leu Pro Pro Arg Glu Arg Val Arg Ala Val Tyr Lys Glu 
        115                 120                 125             


Ala Gln Tyr Tyr Ala Ile Gly Pro Leu Leu Glu Gln Leu Glu Asn Met 
    130                 135                 140                 


Gln Pro Leu Lys Gly Glu Lys Val Arg Gln Ala Phe Leu Gly Leu Met 
145                 150                 155                 160 


Pro Tyr Tyr Lys Asp His Leu Glu Arg Ile Val Glu Ile Ala Arg Leu 
                165                 170                 175     


Arg Ala Val Gln Arg Lys Ala Arg Phe Ala Lys Leu Lys Val Cys Val 
            180                 185                 190         


Phe Lys Glu Glu Met Pro Ile Thr Pro Tyr Glu Cys Pro Leu Leu Asn 
        195                 200                 205             


Ser Leu Arg Phe Glu Arg Ser Glu Ser Asp Gly Gln Leu Phe Glu His 
    210                 215                 220                 


His Cys Glu Val Asp Val Ser Phe Gly Pro Trp Glu Ala Val Ala Asp 
225                 230                 235                 240 


Val Tyr Asp Leu Leu His Cys Leu Val Thr Asp Leu Ser Ala Gln Gly 
                245                 250                 255     


Leu Thr Val Asp His Gln Cys Ile Gly Val Cys Asp Lys His Leu Val 
            260                 265                 270         


Asn His Tyr Tyr Cys Lys Arg Pro Ile Tyr Glu Phe Lys Ile Thr Trp 
        275                 280                 285             


<210>  5802
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KCTD9__Homo_sapiens__NP_060104

<400>  5802

Met Arg Arg Val Thr Leu Phe Leu Asn Gly Ser Pro Lys Asn Gly Lys 
1               5                   10                  15      


Val Val Ala Val Tyr Gly Thr Leu Ser Asp Leu Leu Ser Val Ala Ser 
            20                  25                  30          


Ser Lys Leu Gly Ile Lys Ala Thr Ser Val Tyr Asn Gly Lys Gly Gly 
        35                  40                  45              


Leu Ile Asp Asp Ile Ala Leu Ile Arg Asp Asp Asp Val Leu Phe Val 
    50                  55                  60                  


Cys Glu Gly Glu Pro Phe Ile Asp Pro Gln Thr Asp Ser Lys Pro Pro 
65                  70                  75                  80  


Glu Gly Leu Leu Gly Phe His Thr Asp Trp Leu Thr Leu Asn Val Gly 
                85                  90                  95      


Gly Arg Tyr Phe Thr Thr Thr Arg Ser Thr Leu Val Asn Lys Glu Pro 
            100                 105                 110         


Asp Ser Met Leu Ala His Met Phe Lys Asp Lys Gly Val Trp Gly Asn 
        115                 120                 125             


Lys Gln Asp His Arg Gly Ala Phe Leu Ile Asp Arg Ser Pro Glu Tyr 
    130                 135                 140                 


Phe Glu Pro Ile Leu Asn Tyr Leu Arg His Gly Gln Leu Ile Val Asn 
145                 150                 155                 160 


Asp Gly Ile Asn Leu Leu Gly Val Leu Glu Glu Ala Arg Phe Phe Gly 
                165                 170                 175     


Ile Asp Ser Leu Ile Glu His Leu Glu Val Ala Ile Lys Asn Ser Gln 
            180                 185                 190         


Pro Pro Glu Asp His Ser Pro Ile Ser Arg Lys Glu Phe Val Arg Phe 
        195                 200                 205             


Leu Leu Ala Thr Pro Thr Lys Ser Glu Leu Arg Cys Gln Gly Leu Asn 
    210                 215                 220                 


Phe Ser Gly Ala Asp Leu Ser Arg Leu Asp Leu Arg Tyr Ile Asn Phe 
225                 230                 235                 240 


Lys Met Ala Asn Leu Ser Arg Cys Asn Leu Ala His Ala Asn Leu Cys 
                245                 250                 255     


Cys Ala Asn Leu Glu Arg Ala Asp Leu Ser Gly Ser Val Leu Asp Cys 
            260                 265                 270         


Ala Asn Leu Gln Gly Val Lys Met Leu Cys Ser Asn Ala Glu Gly Ala 
        275                 280                 285             


Ser Leu Lys Leu Cys Asn Phe Glu Asp Pro Ser Gly Leu Lys Ala Asn 
    290                 295                 300                 


Leu Glu Gly Ala Asn Leu Lys Gly Val Asp Met Glu Gly Ser Gln Met 
305                 310                 315                 320 


Thr Gly Ile Asn Leu Arg Val Ala Thr Leu Lys Asn Ala Lys Leu Lys 
                325                 330                 335     


Asn Cys Asn Leu Arg Gly Ala Thr Leu Ala Gly Thr Asp Leu Glu Asn 
            340                 345                 350         


Cys Asp Leu Ser Gly Cys Asp Leu Gln Glu Ala Asn Leu Arg Gly Ser 
        355                 360                 365             


Asn Val Lys Gly Ala Ile Phe Glu Glu Met Leu Thr Pro Leu His Met 
    370                 375                 380                 


Ser Gln Ser Val Arg 
385                 


<210>  5803
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDELC1__Homo_sapiens__NP_076994

<400>  5803

Met Phe Gly Thr Leu Leu Leu Tyr Cys Phe Phe Leu Ala Thr Val Pro 
1               5                   10                  15      


Ala Leu Ala Glu Thr Gly Gly Glu Arg Gln Leu Ser Pro Glu Lys Ser 
            20                  25                  30          


Glu Ile Trp Gly Pro Gly Leu Lys Ala Asp Val Val Leu Pro Ala Arg 
        35                  40                  45              


Tyr Phe Tyr Ile Gln Ala Val Asp Thr Ser Gly Asn Lys Phe Thr Ser 
    50                  55                  60                  


Ser Pro Gly Glu Lys Val Phe Gln Val Lys Val Ser Ala Pro Glu Glu 
65                  70                  75                  80  


Gln Phe Thr Arg Val Gly Val Gln Val Leu Asp Arg Lys Asp Gly Ser 
                85                  90                  95      


Phe Ile Val Arg Tyr Arg Met Tyr Ala Ser Tyr Lys Asn Leu Lys Val 
            100                 105                 110         


Glu Ile Lys Phe Gln Gly Gln His Val Ala Lys Ser Pro Tyr Ile Leu 
        115                 120                 125             


Lys Gly Pro Val Tyr His Glu Asn Cys Asp Cys Pro Leu Gln Asp Ser 
    130                 135                 140                 


Ala Ala Trp Leu Arg Glu Met Asn Cys Pro Glu Thr Ile Ala Gln Ile 
145                 150                 155                 160 


Gln Arg Asp Leu Ala His Phe Pro Ala Val Asp Pro Glu Lys Ile Ala 
                165                 170                 175     


Val Glu Ile Pro Lys Arg Phe Gly Gln Arg Gln Ser Leu Cys His Tyr 
            180                 185                 190         


Thr Leu Lys Asp Asn Lys Val Tyr Ile Lys Thr His Gly Glu His Val 
        195                 200                 205             


Gly Phe Arg Ile Phe Met Asp Ala Ile Leu Leu Ser Leu Thr Arg Lys 
    210                 215                 220                 


Val Lys Met Pro Asp Val Glu Leu Phe Val Asn Leu Gly Asp Trp Pro 
225                 230                 235                 240 


Leu Glu Lys Lys Lys Ser Asn Ser Asn Ile His Pro Ile Phe Ser Trp 
                245                 250                 255     


Cys Gly Ser Thr Asp Ser Lys Asp Ile Val Met Pro Thr Tyr Asp Leu 
            260                 265                 270         


Thr Asp Ser Val Leu Glu Thr Met Gly Arg Val Ser Leu Asp Met Met 
        275                 280                 285             


Ser Val Gln Ala Asn Thr Gly Pro Pro Trp Glu Ser Lys Asn Ser Thr 
    290                 295                 300                 


Ala Val Trp Arg Gly Arg Asp Ser Arg Lys Glu Arg Leu Glu Leu Val 
305                 310                 315                 320 


Lys Leu Ser Arg Lys His Pro Glu Leu Ile Asp Ala Ala Phe Thr Asn 
                325                 330                 335     


Phe Phe Phe Phe Lys His Asp Glu Asn Leu Tyr Gly Pro Ile Val Lys 
            340                 345                 350         


His Ile Ser Phe Phe Asp Phe Phe Lys His Lys Tyr Gln Ile Asn Ile 
        355                 360                 365             


Asp Gly Thr Val Ala Ala Tyr Arg Leu Pro Tyr Leu Leu Val Gly Asp 
    370                 375                 380                 


Ser Val Val Leu Lys Gln Asp Ser Ile Tyr Tyr Glu His Phe Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Pro Trp Lys His Tyr Ile Pro Val Lys Ser Asn Leu Ser 
                405                 410                 415     


Asp Leu Leu Glu Lys Leu Lys Trp Ala Lys Asp His Asp Glu Glu Ala 
            420                 425                 430         


Lys Lys Ile Ala Lys Ala Gly Gln Glu Phe Ala Arg Asn Asn Leu Met 
        435                 440                 445             


Gly Asp Asp Ile Phe Cys Tyr Tyr Phe Lys Leu Phe Gln Glu Tyr Ala 
    450                 455                 460                 


Asn Leu Gln Val Ser Glu Pro Gln Ile Arg Glu Gly Met Lys Arg Val 
465                 470                 475                 480 


Glu Pro Gln Thr Glu Asp Asp Leu Phe Pro Cys Thr Cys His Arg Lys 
                485                 490                 495     


Lys Thr Lys Asp Glu Leu 
            500         


<210>  5804
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDELR1__Homo_sapiens__NP_006792

<400>  5804

Met Asn Leu Phe Arg Phe Leu Gly Asp Leu Ser His Leu Leu Ala Ile 
1               5                   10                  15      


Ile Leu Leu Leu Leu Lys Ile Trp Lys Ser Arg Ser Cys Ala Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Val Leu Phe Ala Val Val Phe Thr Ala Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Asn Tyr Ile Ser Leu Tyr Asn Thr Cys Met Lys 
    50                  55                  60                  


Val Val Tyr Ile Ala Cys Ser Phe Thr Thr Val Trp Leu Ile Tyr Ser 
65                  70                  75                  80  


Lys Phe Lys Ala Thr Tyr Asp Gly Asn His Asp Thr Phe Arg Val Glu 
                85                  90                  95      


Phe Leu Val Val Pro Thr Ala Ile Leu Ala Phe Leu Val Asn His Asp 
            100                 105                 110         


Phe Thr Pro Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Val Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Ser His Tyr Leu Phe Ala Leu Gly Val Tyr Arg Thr 
145                 150                 155                 160 


Leu Tyr Leu Phe Asn Trp Ile Trp Arg Tyr His Phe Glu Gly Phe Phe 
                165                 170                 175     


Asp Leu Ile Ala Ile Val Ala Gly Leu Val Gln Thr Val Leu Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Ile Thr Lys Val Leu Lys Gly Lys Lys Leu 
        195                 200                 205             


Ser Leu Pro Ala 
    210         


<210>  5805
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM2A__Homo_sapiens__NP_001243334

<400>  5805

Met Cys Ser Gly Arg Phe Gln Asn Ile Gln Val Asn Pro Asp Phe Pro 
1               5                   10                  15      


Arg Gly Arg Ile Ser Asn Ser Phe Arg Arg Thr Ser Ser Thr Glu Asn 
            20                  25                  30          


Lys Thr Lys Thr Leu Gly Lys Leu His Gln Glu Pro Arg Gln Leu Gln 
        35                  40                  45              


Ser Asp Gly Lys Arg Lys Ile Leu Leu Glu Glu Leu Ala Asn Ser Asp 
    50                  55                  60                  


Pro Lys Leu Ala Leu Thr Gly Val Pro Ile Val Gln Trp Pro Lys Arg 
65                  70                  75                  80  


Asp Lys Leu Lys Phe Pro Thr Arg Pro Lys Val Arg Val Pro Thr Ile 
                85                  90                  95      


Pro Ile Thr Lys Pro His Thr Met Lys Pro Ala Pro Arg Leu Thr Pro 
            100                 105                 110         


Val Arg Pro Ala Ala Ala Ser Pro Ile Val Ser Gly Ala Arg Arg Arg 
        115                 120                 125             


Arg Val Arg Cys Arg Lys Cys Lys Ala Cys Val Gln Gly Glu Cys Gly 
    130                 135                 140                 


Val Cys His Tyr Cys Arg Asp Met Lys Lys Phe Gly Gly Pro Gly Arg 
145                 150                 155                 160 


Met Lys Gln Ser Cys Val Leu Arg Gln Cys Leu Ala Pro Arg Leu Pro 
                165                 170                 175     


His Ser Val Thr Cys Ser Leu Cys Gly Glu Val Asp Gln Asn Glu Glu 
            180                 185                 190         


Thr Gln Asp Phe Glu Lys Lys Leu Met Glu Cys Cys Ile Cys Asn Glu 
        195                 200                 205             


Ile Val His Pro Gly Cys Leu Gln Met Asp Gly Glu Gly Leu Leu Asn 
    210                 215                 220                 


Glu Glu Leu Pro Asn Cys Trp Glu Cys Pro Lys Cys Tyr Gln Glu Asp 
225                 230                 235                 240 


Ser Ser Glu Lys Ala Gln Lys Arg Lys Met Glu Glu Ser Asp Glu Glu 
                245                 250                 255     


Ala Val Gln Ala Lys Val Leu Arg Pro Leu Arg Ser Cys Asp Glu Pro 
            260                 265                 270         


Leu Thr Pro Pro Pro His Ser Pro Thr Ser Met Leu Gln Leu Ile His 
        275                 280                 285             


Asp Pro Val Ser Pro Arg Gly Met Val Thr Arg Ser Ser Pro Gly Ala 
    290                 295                 300                 


Gly Pro Ser Asp His His Ser Ala Ser Arg Asp Glu Arg Phe Lys Arg 
305                 310                 315                 320 


Arg Gln Leu Leu Arg Leu Gln Ala Thr Glu Arg Thr Met Val Arg Glu 
                325                 330                 335     


Lys Glu Asn Asn Pro Ser Gly Lys Lys Glu Leu Ser Glu Val Glu Lys 
            340                 345                 350         


Ala Lys Ile Arg Gly Ser Tyr Leu Thr Val Thr Leu Gln Arg Pro Thr 
        355                 360                 365             


Lys Glu Leu His Gly Thr Ser Ile Val Pro Lys Leu Gln Ala Ile Thr 
    370                 375                 380                 


Ala Ser Ser Ala Asn Leu Arg His Ser Pro Arg Val Leu Val Gln His 
385                 390                 395                 400 


Cys Pro Ala Arg Thr Pro Gln Arg Gly Asp Glu Glu Gly Leu Gly Gly 
                405                 410                 415     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Ser Ala Glu 
            420                 425                 430         


Glu Gly Gly Ala Ala Arg Leu Asn Gly Arg Gly Ser Trp Ala Gln Asp 
        435                 440                 445             


Gly Asp Glu Ser Trp Met Gln Arg Glu Val Trp Met Ser Val Phe Arg 
    450                 455                 460                 


Tyr Leu Ser Arg Arg Glu Leu Cys Glu Cys Met Arg Val Cys Lys Thr 
465                 470                 475                 480 


Trp Tyr Lys Trp Cys Cys Asp Lys Arg Leu Trp Thr Lys Ile Asp Leu 
                485                 490                 495     


Ser Arg Cys Lys Ala Ile Val Pro Gln Ala Leu Ser Gly Ile Ile Lys 
            500                 505                 510         


Arg Gln Pro Val Ser Leu Asp Leu Ser Trp Thr Asn Ile Ser Lys Lys 
        515                 520                 525             


Gln Leu Thr Trp Leu Val Asn Arg Leu Pro Gly Leu Lys Asp Leu Leu 
    530                 535                 540                 


Leu Ala Gly Cys Ser Trp Ser Ala Val Ser Ala Leu Ser Thr Ser Ser 
545                 550                 555                 560 


Cys Pro Leu Leu Arg Thr Leu Asp Leu Arg Trp Ala Val Gly Ile Lys 
                565                 570                 575     


Asp Pro Gln Ile Arg Asp Leu Leu Thr Pro Pro Ala Asp Lys Pro Gly 
            580                 585                 590         


Gln Asp Asn Arg Ser Lys Leu Arg Asn Met Thr Asp Phe Arg Leu Ala 
        595                 600                 605             


Gly Leu Asp Ile Thr Asp Ala Thr Leu Arg Leu Ile Ile Arg His Met 
    610                 615                 620                 


Pro Leu Leu Ser Arg Leu Asp Leu Ser His Cys Ser His Leu Thr Asp 
625                 630                 635                 640 


Gln Ser Ser Asn Leu Leu Thr Ala Val Gly Ser Ser Thr Arg Tyr Ser 
                645                 650                 655     


Leu Thr Glu Leu Asn Met Ala Gly Cys Asn Lys Leu Thr Asp Gln Thr 
            660                 665                 670         


Leu Ile Tyr Leu Arg Arg Ile Ala Asn Val Thr Leu Ile Asp Leu Arg 
        675                 680                 685             


Gly Cys Lys Gln Ile Thr Arg Lys Ala Cys Glu His Phe Ile Ser Asp 
    690                 695                 700                 


Leu Ser Ile Asn Ser Leu Tyr Cys Leu Ser Asp Glu Lys Leu Ile Gln 
705                 710                 715                 720 


Lys Ile Ser 
            


<210>  5806
<211>  1265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM2B__Homo_sapiens__NP_001005366

<400>  5806

Met Glu Ala Glu Lys Asp Ser Gly Arg Arg Leu Arg Pro Ile Asp Arg 
1               5                   10                  15      


Gln Arg Tyr Asp Glu Asn Glu Asp Leu Ser Asp Val Glu Glu Ile Val 
            20                  25                  30          


Ser Val Arg Gly Phe Ser Leu Glu Glu Lys Leu Arg Ser Gln Leu Tyr 
        35                  40                  45              


Gln Gly Asp Phe Val His Ala Met Glu Gly Lys Asp Phe Asn Tyr Glu 
    50                  55                  60                  


Tyr Val Gln Arg Glu Ala Leu Arg Val Pro Leu Ile Phe Arg Glu Lys 
65                  70                  75                  80  


Asp Gly Leu Gly Ile Lys Met Pro Asp Pro Asp Phe Thr Val Arg Asp 
                85                  90                  95      


Val Lys Leu Leu Val Gly Ser Arg Arg Leu Val Asp Val Met Asp Val 
            100                 105                 110         


Asn Thr Gln Lys Gly Thr Glu Met Ser Met Ser Gln Phe Val Arg Tyr 
        115                 120                 125             


Tyr Glu Thr Pro Glu Ala Gln Arg Asp Lys Leu Tyr Asn Val Ile Ser 
    130                 135                 140                 


Leu Glu Phe Ser His Thr Lys Leu Glu His Leu Val Lys Arg Pro Thr 
145                 150                 155                 160 


Val Val Asp Leu Val Asp Trp Val Asp Asn Met Trp Pro Gln His Leu 
                165                 170                 175     


Lys Glu Lys Gln Thr Glu Ala Thr Asn Ala Ile Ala Glu Met Lys Tyr 
            180                 185                 190         


Pro Lys Val Lys Lys Tyr Cys Leu Met Ser Val Lys Gly Cys Phe Thr 
        195                 200                 205             


Asp Phe His Ile Asp Phe Gly Gly Thr Ser Val Trp Tyr His Val Phe 
    210                 215                 220                 


Arg Gly Gly Lys Ile Phe Trp Leu Ile Pro Pro Thr Leu His Asn Leu 
225                 230                 235                 240 


Ala Leu Tyr Glu Glu Trp Val Leu Ser Gly Lys Gln Ser Asp Ile Phe 
                245                 250                 255     


Leu Gly Asp Arg Val Glu Arg Cys Gln Arg Ile Glu Leu Lys Gln Gly 
            260                 265                 270         


Tyr Thr Phe Phe Ile Pro Ser Gly Trp Ile His Ala Val Tyr Thr Pro 
        275                 280                 285             


Val Asp Ser Leu Val Phe Gly Gly Asn Ile Leu His Ser Phe Asn Val 
    290                 295                 300                 


Pro Met Gln Leu Arg Ile Tyr Glu Ile Glu Asp Arg Thr Arg Val Gln 
305                 310                 315                 320 


Pro Lys Phe Arg Tyr Pro Phe Tyr Tyr Glu Met Cys Trp Tyr Val Leu 
                325                 330                 335     


Glu Arg Tyr Val Tyr Cys Val Thr Gln Arg Ser His Leu Thr Gln Glu 
            340                 345                 350         


Tyr Gln Arg Glu Ser Met Leu Ile Asp Ala Pro Arg Lys Pro Ser Ile 
        355                 360                 365             


Asp Gly Phe Ser Ser Asp Ser Trp Leu Glu Met Glu Glu Glu Ala Cys 
    370                 375                 380                 


Asp Gln Gln Pro Gln Glu Glu Glu Glu Lys Asp Glu Glu Gly Glu Gly 
385                 390                 395                 400 


Arg Asp Arg Ala Pro Lys Pro Pro Thr Asp Gly Ser Thr Ser Pro Thr 
                405                 410                 415     


Ser Thr Pro Ser Glu Asp Gln Glu Ala Leu Gly Lys Lys Pro Lys Ala 
            420                 425                 430         


Pro Ala Leu Arg Phe Leu Lys Arg Thr Leu Ser Asn Glu Ser Glu Glu 
        435                 440                 445             


Ser Val Lys Ser Thr Thr Leu Ala Val Asp Tyr Pro Lys Thr Pro Thr 
    450                 455                 460                 


Gly Ser Pro Ala Thr Glu Val Ser Ala Lys Trp Thr His Leu Thr Glu 
465                 470                 475                 480 


Phe Glu Leu Lys Gly Leu Lys Ala Leu Val Glu Lys Leu Glu Ser Leu 
                485                 490                 495     


Pro Glu Asn Lys Lys Cys Val Pro Glu Gly Ile Glu Asp Pro Gln Ala 
            500                 505                 510         


Leu Leu Glu Gly Val Lys Asn Val Leu Lys Glu His Ala Asp Asp Asp 
        515                 520                 525             


Pro Ser Leu Ala Ile Thr Gly Val Pro Val Val Thr Trp Pro Lys Lys 
    530                 535                 540                 


Thr Pro Lys Asn Arg Ala Val Gly Arg Pro Lys Gly Lys Leu Gly Pro 
545                 550                 555                 560 


Ala Ser Ala Val Lys Leu Ala Ala Asn Arg Thr Thr Ala Gly Ala Arg 
                565                 570                 575     


Arg Arg Arg Thr Arg Cys Arg Lys Cys Glu Ala Cys Leu Arg Thr Glu 
            580                 585                 590         


Cys Gly Glu Cys His Phe Cys Lys Asp Met Lys Lys Phe Gly Gly Pro 
        595                 600                 605             


Gly Arg Met Lys Gln Ser Cys Ile Met Arg Gln Cys Ile Ala Pro Val 
    610                 615                 620                 


Leu Pro His Thr Ala Val Cys Leu Val Cys Gly Glu Ala Gly Lys Glu 
625                 630                 635                 640 


Asp Thr Val Glu Glu Glu Glu Gly Lys Phe Asn Leu Met Leu Met Glu 
                645                 650                 655     


Cys Ser Ile Cys Asn Glu Ile Ile His Pro Gly Cys Leu Lys Ile Lys 
            660                 665                 670         


Glu Ser Glu Gly Val Val Asn Asp Glu Leu Pro Asn Cys Trp Glu Cys 
        675                 680                 685             


Pro Lys Cys Asn His Ala Gly Lys Thr Gly Lys Gln Lys Arg Gly Pro 
    690                 695                 700                 


Gly Phe Lys Tyr Ala Ser Asn Leu Pro Gly Ser Leu Leu Lys Glu Gln 
705                 710                 715                 720 


Lys Met Asn Arg Asp Asn Lys Glu Gly Gln Glu Pro Ala Lys Arg Arg 
                725                 730                 735     


Ser Glu Cys Glu Glu Ala Pro Arg Arg Arg Ser Asp Glu His Ser Lys 
            740                 745                 750         


Lys Val Pro Pro Asp Gly Leu Leu Arg Arg Lys Ser Asp Asp Val His 
        755                 760                 765             


Leu Arg Lys Lys Arg Lys Tyr Glu Lys Pro Gln Glu Leu Ser Gly Arg 
    770                 775                 780                 


Lys Arg Leu Lys Pro Gly Lys Glu Asp Lys Leu Phe Arg Lys Lys Arg 
785                 790                 795                 800 


Arg Ser Trp Lys Asn Ala Glu Asp Arg Met Ala Leu Ala Asn Lys Pro 
                805                 810                 815     


Leu Arg Arg Phe Lys Gln Glu Pro Glu Asp Glu Leu Pro Glu Ala Pro 
            820                 825                 830         


Pro Lys Thr Arg Glu Ser Asp His Ser Arg Ser Ser Ser Pro Thr Ala 
        835                 840                 845             


Gly Pro Ser Thr Glu Gly Ala Glu Gly Pro Glu Glu Lys Lys Lys Val 
    850                 855                 860                 


Lys Met Arg Arg Lys Arg Arg Leu Pro Asn Lys Glu Leu Ser Arg Glu 
865                 870                 875                 880 


Leu Ser Lys Glu Leu Asn His Glu Ile Gln Arg Thr Glu Asn Ser Leu 
                885                 890                 895     


Ala Asn Glu Asn Gln Gln Pro Ile Lys Ser Glu Pro Glu Ser Glu Gly 
            900                 905                 910         


Glu Glu Pro Lys Arg Pro Pro Gly Ile Cys Glu Arg Pro His Arg Phe 
        915                 920                 925             


Ser Lys Gly Leu Asn Gly Thr Pro Arg Glu Leu Arg His Gln Leu Gly 
    930                 935                 940                 


Pro Ser Leu Arg Ser Pro Pro Arg Val Ile Ser Arg Pro Pro Pro Ser 
945                 950                 955                 960 


Val Ser Pro Pro Lys Cys Ile Gln Met Glu Arg His Val Ile Arg Pro 
                965                 970                 975     


Pro Pro Ile Ser Pro Pro Pro Asp Ser Leu Pro Leu Asp Asp Gly Ala 
            980                 985                 990         


Ala His Val Met His Arg Glu Val  Trp Met Ala Val Phe  Ser Tyr Leu 
        995                 1000                 1005             


Ser His  Gln Asp Leu Cys Val  Cys Met Arg Val Cys  Arg Thr Trp 
    1010                 1015                 1020             


Asn Arg  Trp Cys Cys Asp Lys  Arg Leu Trp Thr Arg  Ile Asp Leu 
    1025                 1030                 1035             


Asn His  Cys Lys Ser Ile Thr  Pro Leu Met Leu Ser  Gly Ile Ile 
    1040                 1045                 1050             


Arg Arg  Gln Pro Val Ser Leu  Asp Leu Ser Trp Thr  Asn Ile Ser 
    1055                 1060                 1065             


Lys Lys  Gln Leu Ser Trp Leu  Ile Asn Arg Leu Pro  Gly Leu Arg 
    1070                 1075                 1080             


Asp Leu  Val Leu Ser Gly Cys  Ser Trp Ile Ala Val  Ser Ala Leu 
    1085                 1090                 1095             


Cys Ser  Ser Ser Cys Pro Leu  Leu Arg Thr Leu Asp  Val Gln Trp 
    1100                 1105                 1110             


Val Glu  Gly Leu Lys Asp Ala  Gln Met Arg Asp Leu  Leu Ser Pro 
    1115                 1120                 1125             


Pro Thr  Asp Asn Arg Pro Gly  Gln Met Asp Asn Arg  Ser Lys Leu 
    1130                 1135                 1140             


Arg Asn  Ile Val Glu Leu Arg  Leu Ala Gly Leu Asp  Ile Thr Asp 
    1145                 1150                 1155             


Ala Ser  Leu Arg Leu Ile Ile  Arg His Met Pro Leu  Leu Ser Lys 
    1160                 1165                 1170             


Leu His  Leu Ser Tyr Cys Asn  His Val Thr Asp Gln  Ser Ile Asn 
    1175                 1180                 1185             


Leu Leu  Thr Ala Val Gly Thr  Thr Thr Arg Asp Ser  Leu Thr Glu 
    1190                 1195                 1200             


Ile Asn  Leu Ser Asp Cys Asn  Lys Val Thr Asp Gln  Cys Leu Ser 
    1205                 1210                 1215             


Phe Phe  Lys Arg Cys Gly Asn  Ile Cys His Ile Asp  Leu Arg Tyr 
    1220                 1225                 1230             


Cys Lys  Gln Val Thr Lys Glu  Gly Cys Glu Gln Phe  Ile Ala Glu 
    1235                 1240                 1245             


Met Ser  Ser Phe Gln Gly Arg  Ser Cys Ser Thr Thr  Arg Leu Gly 
    1250                 1255                 1260             


Asp Glu  
    1265 


<210>  5807
<211>  1321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM3A__Homo_sapiens__NP_060903

<400>  5807

Met Val Leu Thr Leu Gly Glu Ser Trp Pro Val Leu Val Gly Arg Arg 
1               5                   10                  15      


Phe Leu Ser Leu Ser Ala Ala Asp Gly Ser Asp Gly Ser His Asp Ser 
            20                  25                  30          


Trp Asp Val Glu Arg Val Ala Glu Trp Pro Trp Leu Ser Gly Thr Ile 
        35                  40                  45              


Arg Ala Val Ser His Thr Asp Val Thr Lys Lys Asp Leu Lys Val Cys 
    50                  55                  60                  


Val Glu Phe Asp Gly Glu Ser Trp Arg Lys Arg Arg Trp Ile Glu Val 
65                  70                  75                  80  


Tyr Ser Leu Leu Arg Arg Ala Phe Leu Val Glu His Asn Leu Val Leu 
                85                  90                  95      


Ala Glu Arg Lys Ser Pro Glu Ile Ser Glu Arg Ile Val Gln Trp Pro 
            100                 105                 110         


Ala Ile Thr Tyr Lys Pro Leu Leu Asp Lys Ala Gly Leu Gly Ser Ile 
        115                 120                 125             


Thr Ser Val Arg Phe Leu Gly Asp Gln Gln Arg Val Phe Leu Ser Lys 
    130                 135                 140                 


Asp Leu Leu Lys Pro Ile Gln Asp Val Asn Ser Leu Arg Leu Ser Leu 
145                 150                 155                 160 


Thr Asp Asn Gln Ile Val Ser Lys Glu Phe Gln Ala Leu Ile Val Lys 
                165                 170                 175     


His Leu Asp Glu Ser His Leu Leu Lys Gly Asp Lys Asn Leu Val Gly 
            180                 185                 190         


Ser Glu Val Lys Ile Tyr Ser Leu Asp Pro Ser Thr Gln Trp Phe Ser 
        195                 200                 205             


Ala Thr Val Ile Asn Gly Asn Pro Ala Ser Lys Thr Leu Gln Val Asn 
    210                 215                 220                 


Cys Glu Glu Ile Pro Ala Leu Lys Ile Val Asp Pro Ser Leu Ile His 
225                 230                 235                 240 


Val Glu Val Val His Asp Asn Leu Val Thr Cys Gly Asn Ser Ala Arg 
                245                 250                 255     


Ile Gly Ala Val Lys Arg Lys Ser Ser Glu Asn Asn Gly Thr Leu Val 
            260                 265                 270         


Ser Lys Gln Ala Lys Ser Cys Ser Glu Ala Ser Pro Ser Met Cys Pro 
        275                 280                 285             


Val Gln Ser Val Pro Thr Thr Val Phe Lys Glu Ile Leu Leu Gly Cys 
    290                 295                 300                 


Thr Ala Ala Thr Pro Pro Ser Lys Asp Pro Arg Gln Gln Ser Thr Pro 
305                 310                 315                 320 


Gln Ala Ala Asn Ser Pro Pro Asn Leu Gly Ala Lys Ile Pro Gln Gly 
                325                 330                 335     


Cys His Lys Gln Ser Leu Pro Glu Glu Ile Ser Ser Cys Leu Asn Thr 
            340                 345                 350         


Lys Ser Glu Ala Leu Arg Thr Lys Pro Asp Val Cys Lys Ala Gly Leu 
        355                 360                 365             


Leu Ser Lys Ser Ser Gln Ile Gly Thr Gly Asp Leu Lys Ile Leu Thr 
    370                 375                 380                 


Glu Pro Lys Gly Ser Cys Thr Gln Pro Lys Thr Asn Thr Asp Gln Glu 
385                 390                 395                 400 


Asn Arg Leu Glu Ser Val Pro Gln Ala Leu Thr Gly Leu Pro Lys Glu 
                405                 410                 415     


Cys Leu Pro Thr Lys Ala Ser Ser Lys Ala Glu Leu Glu Ile Ala Asn 
            420                 425                 430         


Pro Pro Glu Leu Gln Lys His Leu Glu His Ala Pro Ser Pro Ser Asp 
        435                 440                 445             


Val Ser Asn Ala Pro Glu Val Lys Ala Gly Val Asn Ser Asp Ser Pro 
    450                 455                 460                 


Asn Asn Cys Ser Gly Lys Lys Val Glu Pro Ser Ala Leu Ala Cys Arg 
465                 470                 475                 480 


Ser Gln Asn Leu Lys Glu Ser Ser Val Lys Val Asp Asn Glu Ser Cys 
                485                 490                 495     


Cys Ser Arg Ser Asn Asn Lys Ile Gln Asn Ala Pro Ser Arg Lys Ser 
            500                 505                 510         


Val Leu Thr Asp Pro Ala Lys Leu Lys Lys Leu Gln Gln Ser Gly Glu 
        515                 520                 525             


Ala Phe Val Gln Asp Asp Ser Cys Val Asn Ile Val Ala Gln Leu Pro 
    530                 535                 540                 


Lys Cys Arg Glu Cys Arg Leu Asp Ser Leu Arg Lys Asp Lys Glu Gln 
545                 550                 555                 560 


Gln Lys Asp Ser Pro Val Phe Cys Arg Phe Phe His Phe Arg Arg Leu 
                565                 570                 575     


Gln Phe Asn Lys His Gly Val Leu Arg Val Glu Gly Phe Leu Thr Pro 
            580                 585                 590         


Asn Lys Tyr Asp Asn Glu Ala Ile Gly Leu Trp Leu Pro Leu Thr Lys 
        595                 600                 605             


Asn Val Val Gly Ile Asp Leu Asp Thr Ala Lys Tyr Ile Leu Ala Asn 
    610                 615                 620                 


Ile Gly Asp His Phe Cys Gln Met Val Ile Ser Glu Lys Glu Ala Met 
625                 630                 635                 640 


Ser Thr Ile Glu Pro His Arg Gln Val Ala Trp Lys Arg Ala Val Lys 
                645                 650                 655     


Gly Val Arg Glu Met Cys Asp Val Cys Asp Thr Thr Ile Phe Asn Leu 
            660                 665                 670         


His Trp Val Cys Pro Arg Cys Gly Phe Gly Val Cys Val Asp Cys Tyr 
        675                 680                 685             


Arg Met Lys Arg Lys Asn Cys Gln Gln Gly Ala Ala Tyr Lys Thr Phe 
    690                 695                 700                 


Ser Trp Leu Lys Cys Val Lys Ser Gln Ile His Glu Pro Glu Asn Leu 
705                 710                 715                 720 


Met Pro Thr Gln Ile Ile Pro Gly Lys Ala Leu Tyr Asp Val Gly Asp 
                725                 730                 735     


Ile Val His Ser Val Arg Ala Lys Trp Gly Ile Lys Ala Asn Cys Pro 
            740                 745                 750         


Cys Ser Asn Arg Gln Phe Lys Leu Phe Ser Lys Pro Ala Ser Lys Glu 
        755                 760                 765             


Asp Leu Lys Gln Thr Ser Leu Ala Gly Glu Lys Pro Thr Leu Gly Ala 
    770                 775                 780                 


Val Leu Gln Gln Asn Pro Ser Val Leu Glu Pro Ala Ala Val Gly Gly 
785                 790                 795                 800 


Glu Ala Ala Ser Lys Pro Ala Gly Ser Met Lys Pro Ala Cys Pro Ala 
                805                 810                 815     


Ser Thr Ser Pro Leu Asn Trp Leu Ala Asp Leu Thr Ser Gly Asn Val 
            820                 825                 830         


Asn Lys Glu Asn Lys Glu Lys Gln Pro Thr Met Pro Ile Leu Lys Asn 
        835                 840                 845             


Glu Ile Lys Cys Leu Pro Pro Leu Pro Pro Leu Ser Lys Ser Ser Thr 
    850                 855                 860                 


Val Leu His Thr Phe Asn Ser Thr Ile Leu Thr Pro Val Ser Asn Asn 
865                 870                 875                 880 


Asn Ser Gly Phe Leu Arg Asn Leu Leu Asn Ser Ser Thr Gly Lys Thr 
                885                 890                 895     


Glu Asn Gly Leu Lys Asn Thr Pro Lys Ile Leu Asp Asp Ile Phe Ala 
            900                 905                 910         


Ser Leu Val Gln Asn Lys Thr Thr Ser Asp Leu Ser Lys Arg Pro Gln 
        915                 920                 925             


Gly Leu Thr Ile Lys Pro Ser Ile Leu Gly Phe Asp Thr Pro His Tyr 
    930                 935                 940                 


Trp Leu Cys Asp Asn Arg Leu Leu Cys Leu Gln Asp Pro Asn Asn Lys 
945                 950                 955                 960 


Ser Asn Trp Asn Val Phe Arg Glu Cys Trp Lys Gln Gly Gln Pro Val 
                965                 970                 975     


Met Val Ser Gly Val His His Lys Leu Asn Ser Glu Leu Trp Lys Pro 
            980                 985                 990         


Glu Ser Phe Arg Lys Glu Phe Gly  Glu Gln Glu Val Asp  Leu Val Asn 
        995                 1000                 1005             


Cys Arg  Thr Asn Glu Ile Ile  Thr Gly Ala Thr Val  Gly Asp Phe 
    1010                 1015                 1020             


Trp Asp  Gly Phe Glu Asp Val  Pro Asn Arg Leu Lys  Asn Glu Lys 
    1025                 1030                 1035             


Glu Pro  Met Val Leu Lys Leu  Lys Asp Trp Pro Pro  Gly Glu Asp 
    1040                 1045                 1050             


Phe Arg  Asp Met Met Pro Ser  Arg Phe Asp Asp Leu  Met Ala Asn 
    1055                 1060                 1065             


Ile Pro  Leu Pro Glu Tyr Thr  Arg Arg Asp Gly Lys  Leu Asn Leu 
    1070                 1075                 1080             


Ala Ser  Arg Leu Pro Asn Tyr  Phe Val Arg Pro Asp  Leu Gly Pro 
    1085                 1090                 1095             


Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr Pro Glu  Asp Arg Lys 
    1100                 1105                 1110             


Tyr Gly  Thr Thr Asn Leu His  Leu Asp Val Ser Asp  Ala Ala Asn 
    1115                 1120                 1125             


Val Met  Val Tyr Val Gly Ile  Pro Lys Gly Gln Cys  Glu Gln Glu 
    1130                 1135                 1140             


Glu Glu  Val Leu Lys Thr Ile  Gln Asp Gly Asp Ser  Asp Glu Leu 
    1145                 1150                 1155             


Thr Ile  Lys Arg Phe Ile Glu  Gly Lys Glu Lys Pro  Gly Ala Leu 
    1160                 1165                 1170             


Trp His  Ile Tyr Ala Ala Lys  Asp Thr Glu Lys Ile  Arg Glu Phe 
    1175                 1180                 1185             


Leu Lys  Lys Val Ser Glu Glu  Gln Gly Gln Glu Asn  Pro Ala Asp 
    1190                 1195                 1200             


His Asp  Pro Ile His Asp Gln  Ser Trp Tyr Leu Asp  Arg Ser Leu 
    1205                 1210                 1215             


Arg Lys  Arg Leu His Gln Glu  Tyr Gly Val Gln Gly  Trp Ala Ile 
    1220                 1225                 1230             


Val Gln  Phe Leu Gly Asp Val  Val Phe Ile Pro Ala  Gly Ala Pro 
    1235                 1240                 1245             


His Gln  Val His Asn Leu Tyr  Ser Cys Ile Lys Val  Ala Glu Asp 
    1250                 1255                 1260             


Phe Val  Ser Pro Glu His Val  Lys His Cys Phe Trp  Leu Thr Gln 
    1265                 1270                 1275             


Glu Phe  Arg Tyr Leu Ser Gln  Thr His Thr Asn His  Glu Asp Lys 
    1280                 1285                 1290             


Leu Gln  Val Lys Asn Val Ile  Tyr His Ala Val Lys  Asp Ala Val 
    1295                 1300                 1305             


Ala Met  Leu Lys Ala Ser Glu  Ser Ser Phe Gly Lys  Pro 
    1310                 1315                 1320     


<210>  5808
<211>  1761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM3B__Homo_sapiens__NP_057688

<400>  5808

Met Ala Asp Ala Ala Ala Ser Pro Val Gly Lys Arg Leu Leu Leu Leu 
1               5                   10                  15      


Phe Ala Asp Thr Ala Ala Ser Ala Ser Ala Ser Ala Pro Ala Ala Ala 
            20                  25                  30          


Ala Ala Ser Gly Asp Pro Gly Pro Ala Leu Arg Thr Arg Ala Trp Arg 
        35                  40                  45              


Ala Gly Thr Val Arg Ala Met Ser Gly Ala Val Pro Gln Asp Leu Ala 
    50                  55                  60                  


Ile Phe Val Glu Phe Asp Gly Cys Asn Trp Lys Gln His Ser Trp Val 
65                  70                  75                  80  


Lys Val His Ala Glu Glu Val Ile Val Leu Leu Leu Glu Gly Ser Leu 
                85                  90                  95      


Val Trp Ala Pro Arg Glu Asp Pro Val Leu Leu Gln Gly Ile Arg Val 
            100                 105                 110         


Ser Ile Ala Gln Trp Pro Ala Leu Thr Phe Thr Pro Leu Val Asp Lys 
        115                 120                 125             


Leu Gly Leu Gly Ser Val Val Pro Val Glu Tyr Leu Leu Asp Arg Glu 
    130                 135                 140                 


Leu Arg Phe Leu Ser Asp Ala Asn Gly Leu His Leu Phe Gln Met Gly 
145                 150                 155                 160 


Thr Asp Ser Gln Asn Gln Ile Leu Leu Glu His Ala Ala Leu Arg Glu 
                165                 170                 175     


Thr Val Asn Ala Leu Ile Ser Asp Gln Lys Leu Gln Glu Ile Phe Ser 
            180                 185                 190         


Arg Gly Pro Tyr Ser Val Gln Gly His Arg Val Lys Ile Tyr Gln Pro 
        195                 200                 205             


Glu Gly Glu Glu Gly Trp Leu Tyr Gly Val Val Ser His Gln Asp Ser 
    210                 215                 220                 


Ile Thr Arg Leu Met Glu Val Ser Val Thr Glu Ser Gly Glu Ile Lys 
225                 230                 235                 240 


Ser Val Asp Pro Arg Leu Ile His Val Met Leu Met Asp Asn Ser Thr 
                245                 250                 255     


Pro Gln Ser Glu Gly Gly Thr Leu Lys Ala Val Lys Ser Ser Lys Gly 
            260                 265                 270         


Lys Lys Lys Arg Glu Ser Ile Glu Gly Lys Asp Gly Arg Arg Arg Lys 
        275                 280                 285             


Ser Ala Ser Asp Ser Gly Cys Asp Pro Ala Ser Lys Lys Leu Lys Gly 
    290                 295                 300                 


Asp Arg Gly Glu Val Asp Ser Asn Gly Ser Asp Gly Gly Glu Ala Ser 
305                 310                 315                 320 


Arg Gly Pro Trp Lys Gly Gly Asn Ala Ser Gly Glu Pro Gly Leu Asp 
                325                 330                 335     


Gln Arg Ala Lys Gln Pro Pro Ser Thr Phe Val Pro Gln Ile Asn Arg 
            340                 345                 350         


Asn Ile Arg Phe Ala Thr Tyr Thr Lys Glu Asn Gly Arg Thr Leu Val 
        355                 360                 365             


Val Gln Asp Glu Pro Val Gly Gly Asp Thr Pro Ala Ser Phe Thr Pro 
    370                 375                 380                 


Tyr Ser Thr Ala Thr Gly Gln Thr Pro Leu Ala Pro Glu Val Gly Gly 
385                 390                 395                 400 


Ala Glu Asn Lys Glu Ala Gly Lys Thr Leu Glu Gln Val Gly Gln Gly 
                405                 410                 415     


Ile Val Ala Ser Ala Ala Val Val Thr Thr Ala Ser Ser Thr Pro Asn 
            420                 425                 430         


Thr Val Arg Ile Ser Asp Thr Gly Leu Ala Ala Gly Thr Val Pro Glu 
        435                 440                 445             


Lys Gln Lys Gly Ser Arg Ser Gln Ala Ser Gly Glu Asn Ser Arg Asn 
    450                 455                 460                 


Ser Ile Leu Ala Ser Ser Gly Phe Gly Ala Pro Leu Pro Ser Ser Ser 
465                 470                 475                 480 


Gln Pro Leu Thr Phe Gly Ser Gly Arg Ser Gln Ser Asn Gly Val Leu 
                485                 490                 495     


Ala Thr Glu Asn Lys Pro Leu Gly Phe Ser Phe Gly Cys Ser Ser Ala 
            500                 505                 510         


Gln Glu Ala Gln Lys Asp Thr Asp Leu Ser Lys Asn Leu Phe Phe Gln 
        515                 520                 525             


Cys Met Ser Gln Thr Leu Pro Thr Ser Asn Tyr Phe Thr Thr Val Ser 
    530                 535                 540                 


Glu Ser Leu Ala Asp Asp Ser Ser Ser Arg Asp Ser Phe Lys Gln Ser 
545                 550                 555                 560 


Leu Glu Ser Leu Ser Ser Gly Leu Cys Lys Gly Arg Ser Val Leu Gly 
                565                 570                 575     


Thr Asp Thr Lys Pro Gly Ser Lys Ala Gly Ser Ser Val Asp Arg Lys 
            580                 585                 590         


Val Pro Ala Glu Ser Met Pro Thr Leu Thr Pro Ala Phe Pro Arg Ser 
        595                 600                 605             


Leu Leu Asn Ala Arg Thr Pro Glu Asn His Glu Asn Leu Phe Leu Gln 
    610                 615                 620                 


Pro Pro Lys Leu Ser Arg Glu Glu Pro Ser Asn Pro Phe Leu Ala Phe 
625                 630                 635                 640 


Val Glu Lys Val Glu His Ser Pro Phe Ser Ser Phe Ala Ser Gln Ala 
                645                 650                 655     


Ser Gly Ser Ser Ser Ser Ala Thr Thr Val Thr Ser Lys Val Ala Pro 
            660                 665                 670         


Ser Trp Pro Glu Ser His Ser Ser Ala Asp Ser Ala Ser Leu Ala Lys 
        675                 680                 685             


Lys Lys Pro Leu Phe Ile Thr Thr Asp Ser Ser Lys Leu Val Ser Gly 
    690                 695                 700                 


Val Leu Gly Ser Ala Leu Thr Ser Gly Gly Pro Ser Leu Ser Ala Met 
705                 710                 715                 720 


Gly Asn Gly Arg Ser Ser Ser Pro Thr Ser Ser Leu Thr Gln Pro Ile 
                725                 730                 735     


Glu Met Pro Thr Leu Ser Ser Ser Pro Thr Glu Glu Arg Pro Thr Val 
            740                 745                 750         


Gly Pro Gly Gln Gln Asp Asn Pro Leu Leu Lys Thr Phe Ser Asn Val 
        755                 760                 765             


Phe Gly Arg His Ser Gly Gly Phe Leu Ser Ser Pro Ala Asp Phe Ser 
    770                 775                 780                 


Gln Glu Asn Lys Ala Pro Phe Glu Ala Val Lys Arg Phe Ser Leu Asp 
785                 790                 795                 800 


Glu Arg Ser Leu Ala Cys Arg Gln Asp Ser Asp Ser Ser Thr Asn Ser 
                805                 810                 815     


Asp Leu Ser Asp Leu Ser Asp Ser Glu Glu Gln Leu Gln Ala Lys Thr 
            820                 825                 830         


Gly Leu Lys Gly Ile Pro Glu His Leu Met Gly Lys Leu Gly Pro Asn 
        835                 840                 845             


Gly Glu Arg Ser Ala Glu Leu Leu Leu Gly Lys Ser Lys Gly Lys Gln 
    850                 855                 860                 


Ala Pro Lys Gly Arg Pro Arg Thr Ala Pro Leu Lys Val Gly Gln Ser 
865                 870                 875                 880 


Val Leu Lys Asp Val Ser Lys Val Lys Lys Leu Lys Gln Ser Gly Glu 
                885                 890                 895     


Pro Phe Leu Gln Asp Gly Ser Cys Ile Asn Val Ala Pro His Leu His 
            900                 905                 910         


Lys Cys Arg Glu Cys Arg Leu Glu Arg Tyr Arg Lys Phe Lys Glu Gln 
        915                 920                 925             


Glu Gln Asp Asp Ser Thr Val Ala Cys Arg Phe Phe His Phe Arg Arg 
    930                 935                 940                 


Leu Ile Phe Thr Arg Lys Gly Val Leu Arg Val Glu Gly Phe Leu Ser 
945                 950                 955                 960 


Pro Gln Gln Ser Asp Pro Asp Ala Met Asn Leu Trp Ile Pro Ser Ser 
                965                 970                 975     


Ser Leu Ala Glu Gly Ile Asp Leu Glu Thr Ser Lys Tyr Ile Leu Ala 
            980                 985                 990         


Asn Val Gly Asp Gln Phe Cys Gln  Leu Val Met Ser Glu  Lys Glu Ala 
        995                 1000                 1005             


Met Met  Met Val Glu Pro His  Gln Lys Val Ala Trp  Lys Arg Ala 
    1010                 1015                 1020             


Val Arg  Gly Val Arg Glu Met  Cys Asp Val Cys Glu  Thr Thr Leu 
    1025                 1030                 1035             


Phe Asn  Ile His Trp Val Cys  Arg Lys Cys Gly Phe  Gly Val Cys 
    1040                 1045                 1050             


Leu Asp  Cys Tyr Arg Leu Arg  Lys Ser Arg Pro Arg  Ser Glu Thr 
    1055                 1060                 1065             


Glu Glu  Met Gly Asp Glu Glu  Val Phe Ser Trp Leu  Lys Cys Ala 
    1070                 1075                 1080             


Lys Gly  Gln Ser His Glu Pro  Glu Asn Leu Met Pro  Thr Gln Ile 
    1085                 1090                 1095             


Ile Pro  Gly Thr Ala Leu Tyr  Asn Ile Gly Asp Met  Val His Ala 
    1100                 1105                 1110             


Ala Arg  Gly Lys Trp Gly Ile  Lys Ala Asn Cys Pro  Cys Ile Ser 
    1115                 1120                 1125             


Arg Gln  Asn Lys Ser Val Leu  Arg Pro Ala Val Thr  Asn Gly Met 
    1130                 1135                 1140             


Ser Gln  Leu Pro Ser Ile Asn  Pro Ser Ala Ser Ser  Gly Asn Glu 
    1145                 1150                 1155             


Thr Thr  Phe Ser Gly Gly Gly  Gly Pro Ala Pro Val  Thr Thr Pro 
    1160                 1165                 1170             


Glu Pro  Asp His Val Pro Lys  Ala Asp Ser Thr Asp  Ile Arg Ser 
    1175                 1180                 1185             


Glu Glu  Pro Leu Lys Thr Asp  Ser Ser Ala Ser Asn  Ser Asn Ser 
    1190                 1195                 1200             


Glu Leu  Lys Ala Ile Arg Pro  Pro Cys Pro Asp Thr  Ala Pro Pro 
    1205                 1210                 1215             


Ser Ser  Ala Leu His Trp Leu  Ala Asp Leu Ala Thr  Gln Lys Ala 
    1220                 1225                 1230             


Lys Glu  Glu Thr Lys Glu Ala  Gly Ser Leu Arg Ser  Val Leu Asn 
    1235                 1240                 1245             


Lys Glu  Ser His Ser Pro Phe  Gly Leu Asp Ser Phe  Asn Ser Thr 
    1250                 1255                 1260             


Ala Lys  Val Ser Pro Leu Thr  Pro Lys Leu Phe Asn  Ser Leu Leu 
    1265                 1270                 1275             


Leu Gly  Pro Thr Ala Ser Asn  Asn Lys Thr Glu Gly  Ser Ser Leu 
    1280                 1285                 1290             


Arg Asp  Leu Leu His Ser Gly  Pro Gly Lys Leu Pro  Gln Thr Pro 
    1295                 1300                 1305             


Leu Asp  Thr Gly Ile Pro Phe  Pro Pro Val Phe Ser  Thr Ser Ser 
    1310                 1315                 1320             


Ala Gly  Val Lys Ser Lys Ala  Ser Leu Pro Asn Phe  Leu Asp His 
    1325                 1330                 1335             


Ile Ile  Ala Ser Val Val Glu  Asn Lys Lys Thr Ser  Asp Ala Ser 
    1340                 1345                 1350             


Lys Arg  Ala Cys Asn Leu Thr  Asp Thr Gln Lys Glu  Val Lys Glu 
    1355                 1360                 1365             


Met Val  Met Gly Leu Asn Val  Leu Asp Pro His Thr  Ser His Ser 
    1370                 1375                 1380             


Trp Leu  Cys Asp Gly Arg Leu  Leu Cys Leu His Asp  Pro Ser Asn 
    1385                 1390                 1395             


Lys Asn  Asn Trp Lys Ile Phe  Arg Glu Cys Trp Lys  Gln Gly Gln 
    1400                 1405                 1410             


Pro Val  Leu Val Ser Gly Val  His Lys Lys Leu Lys  Ser Glu Leu 
    1415                 1420                 1425             


Trp Lys  Pro Glu Ala Phe Ser  Gln Glu Phe Gly Asp  Gln Asp Val 
    1430                 1435                 1440             


Asp Leu  Val Asn Cys Arg Asn  Cys Ala Ile Ile Ser  Asp Val Lys 
    1445                 1450                 1455             


Val Arg  Asp Phe Trp Asp Gly  Phe Glu Ile Ile Cys  Lys Arg Leu 
    1460                 1465                 1470             


Arg Ser  Glu Asp Gly Gln Pro  Met Val Leu Lys Leu  Lys Asp Trp 
    1475                 1480                 1485             


Pro Pro  Gly Glu Asp Phe Arg  Asp Met Met Pro Thr  Arg Phe Glu 
    1490                 1495                 1500             


Asp Leu  Met Glu Asn Leu Pro  Leu Pro Glu Tyr Thr  Lys Arg Asp 
    1505                 1510                 1515             


Gly Arg  Leu Asn Leu Ala Ser  Arg Leu Pro Ser Tyr  Phe Val Arg 
    1520                 1525                 1530             


Pro Asp  Leu Gly Pro Lys Met  Tyr Asn Ala Tyr Gly  Leu Ile Thr 
    1535                 1540                 1545             


Ala Glu  Asp Arg Arg Val Gly  Thr Thr Asn Leu His  Leu Asp Val 
    1550                 1555                 1560             


Ser Asp  Ala Val Asn Val Met  Val Tyr Val Gly Ile  Pro Ile Gly 
    1565                 1570                 1575             


Glu Gly  Ala His Asp Glu Glu  Val Leu Lys Thr Ile  Asp Glu Gly 
    1580                 1585                 1590             


Asp Ala  Asp Glu Val Thr Lys  Gln Arg Ile His Asp  Gly Lys Glu 
    1595                 1600                 1605             


Lys Pro  Gly Ala Leu Trp His  Ile Tyr Ala Ala Lys  Asp Ala Glu 
    1610                 1615                 1620             


Lys Ile  Arg Glu Leu Leu Arg  Lys Val Gly Glu Glu  Gln Gly Gln 
    1625                 1630                 1635             


Glu Asn  Pro Pro Asp His Asp  Pro Ile His Asp Gln  Ser Trp Tyr 
    1640                 1645                 1650             


Leu Asp  Gln Thr Leu Arg Lys  Arg Leu Tyr Glu Glu  Tyr Gly Val 
    1655                 1660                 1665             


Gln Gly  Trp Ala Ile Val Gln  Phe Leu Gly Asp Ala  Val Phe Ile 
    1670                 1675                 1680             


Pro Ala  Gly Ala Pro His Gln  Val His Asn Leu Tyr  Ser Cys Ile 
    1685                 1690                 1695             


Lys Val  Ala Glu Asp Phe Val  Ser Pro Glu His Val  Lys His Cys 
    1700                 1705                 1710             


Phe Arg  Leu Thr Gln Glu Phe  Arg His Leu Ser Asn  Thr His Thr 
    1715                 1720                 1725             


Asn His  Glu Asp Lys Leu Gln  Val Lys Asn Ile Ile  Tyr His Ala 
    1730                 1735                 1740             


Val Lys  Asp Ala Val Gly Thr  Leu Lys Ala His Glu  Ser Lys Leu 
    1745                 1750                 1755             


Ala Arg  Ser 
    1760     


<210>  5809
<211>  1096
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM4B__Homo_sapiens__NP_055830

<400>  5809

Met Gly Ser Glu Asp His Gly Ala Gln Asn Pro Ser Cys Lys Ile Met 
1               5                   10                  15      


Thr Phe Arg Pro Thr Met Glu Glu Phe Lys Asp Phe Asn Lys Tyr Val 
            20                  25                  30          


Ala Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Ile 
        35                  40                  45              


Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Thr Tyr Asp Asp Ile Asp 
    50                  55                  60                  


Asp Val Val Ile Pro Ala Pro Ile Gln Gln Val Val Thr Gly Gln Ser 
65                  70                  75                  80  


Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Gly 
                85                  90                  95      


Glu Tyr Arg Arg Leu Ala Asn Ser Glu Lys Tyr Cys Thr Pro Arg His 
            100                 105                 110         


Gln Asp Phe Asp Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe 
        115                 120                 125             


Val Ser Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu Tyr Asp Asp 
    130                 135                 140                 


Asp Val Ala Gln Trp Asn Ile Gly Ser Leu Arg Thr Ile Leu Asp Met 
145                 150                 155                 160 


Val Glu Arg Glu Cys Gly Thr Ile Ile Glu Gly Val Asn Thr Pro Tyr 
                165                 170                 175     


Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu Asp 
            180                 185                 190         


Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser 
        195                 200                 205             


Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala 
    210                 215                 220                 


Ile Gly Phe Phe Pro Gly Ser Ser Gln Gly Cys Asp Ala Phe Leu Arg 
225                 230                 235                 240 


His Lys Met Thr Leu Ile Ser Pro Ile Ile Leu Lys Lys Tyr Gly Ile 
                245                 250                 255     


Pro Phe Ser Arg Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe 
            260                 265                 270         


Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu 
        275                 280                 285             


Ser Thr Asn Phe Ala Thr Leu Arg Trp Ile Asp Tyr Gly Lys Val Ala 
    290                 295                 300                 


Thr Gln Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val 
305                 310                 315                 320 


Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Glu Leu Trp Lys Gln Gly 
                325                 330                 335     


Lys Asp Leu Thr Val Leu Asp His Thr Arg Pro Thr Ala Leu Thr Ser 
            340                 345                 350         


Pro Glu Leu Ser Ser Trp Ser Ala Ser Arg Ala Ser Leu Lys Ala Lys 
        355                 360                 365             


Leu Leu Arg Arg Ser His Arg Lys Arg Ser Gln Pro Lys Lys Pro Lys 
    370                 375                 380                 


Pro Glu Asp Pro Lys Phe Pro Gly Glu Gly Thr Ala Gly Ala Ala Leu 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Gly Ser Val Lys Glu Glu Ala Gly Pro Glu Val 
                405                 410                 415     


Asp Pro Glu Glu Glu Glu Glu Glu Pro Gln Pro Leu Pro His Gly Arg 
            420                 425                 430         


Glu Ala Glu Gly Ala Glu Glu Asp Gly Arg Gly Lys Leu Arg Pro Thr 
        435                 440                 445             


Lys Ala Lys Ser Glu Arg Lys Lys Lys Ser Phe Gly Leu Leu Pro Pro 
    450                 455                 460                 


Gln Leu Pro Pro Pro Pro Ala His Phe Pro Ser Glu Glu Ala Leu Trp 
465                 470                 475                 480 


Leu Pro Ser Pro Leu Glu Pro Pro Val Leu Gly Pro Gly Pro Ala Ala 
                485                 490                 495     


Met Glu Glu Ser Pro Leu Pro Ala Pro Leu Asn Val Val Pro Pro Glu 
            500                 505                 510         


Val Pro Ser Glu Glu Leu Glu Ala Lys Pro Arg Pro Ile Ile Pro Met 
        515                 520                 525             


Leu Tyr Val Val Pro Arg Pro Gly Lys Ala Ala Phe Asn Gln Glu His 
    530                 535                 540                 


Val Ser Cys Gln Gln Ala Phe Glu His Phe Ala Gln Lys Gly Pro Thr 
545                 550                 555                 560 


Trp Lys Glu Pro Val Ser Pro Met Glu Leu Thr Gly Pro Glu Asp Gly 
                565                 570                 575     


Ala Ala Ser Ser Gly Ala Gly Arg Met Glu Thr Lys Ala Arg Ala Gly 
            580                 585                 590         


Glu Gly Gln Ala Pro Ser Thr Phe Ser Lys Leu Lys Met Glu Ile Lys 
        595                 600                 605             


Lys Ser Arg Arg His Pro Leu Gly Arg Pro Pro Thr Arg Ser Pro Leu 
    610                 615                 620                 


Ser Val Val Lys Gln Glu Ala Ser Ser Asp Glu Glu Ala Ser Pro Phe 
625                 630                 635                 640 


Ser Gly Glu Glu Asp Val Ser Asp Pro Asp Ala Leu Arg Pro Leu Leu 
                645                 650                 655     


Ser Leu Gln Trp Lys Asn Arg Ala Ala Ser Phe Gln Ala Glu Arg Lys 
            660                 665                 670         


Phe Asn Ala Ala Ala Ala Arg Thr Glu Pro Tyr Cys Ala Ile Cys Thr 
        675                 680                 685             


Leu Phe Tyr Pro Tyr Cys Gln Ala Leu Gln Thr Glu Lys Glu Ala Pro 
    690                 695                 700                 


Ile Ala Ser Leu Gly Glu Gly Cys Pro Ala Thr Leu Pro Ser Lys Ser 
705                 710                 715                 720 


Arg Gln Lys Thr Arg Pro Leu Ile Pro Glu Met Cys Phe Thr Ser Gly 
                725                 730                 735     


Gly Glu Asn Thr Glu Pro Leu Pro Ala Asn Ser Tyr Ile Gly Asp Asp 
            740                 745                 750         


Gly Thr Ser Pro Leu Ile Ala Cys Gly Lys Cys Cys Leu Gln Val His 
        755                 760                 765             


Ala Ser Cys Tyr Gly Ile Arg Pro Glu Leu Val Asn Glu Gly Trp Thr 
    770                 775                 780                 


Cys Ser Arg Cys Ala Ala His Ala Trp Thr Ala Glu Cys Cys Leu Cys 
785                 790                 795                 800 


Asn Leu Arg Gly Gly Ala Leu Gln Met Thr Thr Asp Arg Arg Trp Ile 
                805                 810                 815     


His Val Ile Cys Ala Ile Ala Val Pro Glu Ala Arg Phe Leu Asn Val 
            820                 825                 830         


Ile Glu Arg His Pro Val Asp Ile Ser Ala Ile Pro Glu Gln Arg Trp 
        835                 840                 845             


Lys Leu Lys Cys Val Tyr Cys Arg Lys Arg Met Lys Lys Val Ser Gly 
    850                 855                 860                 


Ala Cys Ile Gln Cys Ser Tyr Glu His Cys Ser Thr Ser Phe His Val 
865                 870                 875                 880 


Thr Cys Ala His Ala Ala Gly Val Leu Met Glu Pro Asp Asp Trp Pro 
                885                 890                 895     


Tyr Val Val Ser Ile Thr Cys Leu Lys His Lys Ser Gly Gly His Ala 
            900                 905                 910         


Val Gln Leu Leu Arg Ala Val Ser Leu Gly Gln Val Val Ile Thr Lys 
        915                 920                 925             


Asn Arg Asn Gly Leu Tyr Tyr Arg Cys Arg Val Ile Gly Ala Ala Ser 
    930                 935                 940                 


Gln Thr Cys Tyr Glu Val Asn Phe Asp Asp Gly Ser Tyr Ser Asp Asn 
945                 950                 955                 960 


Leu Tyr Pro Glu Ser Ile Thr Ser Arg Asp Cys Val Gln Leu Gly Pro 
                965                 970                 975     


Pro Ser Glu Gly Glu Leu Val Glu Leu Arg Trp Thr Asp Gly Asn Leu 
            980                 985                 990         


Tyr Lys Ala Lys Phe Ile Ser Ser  Val Thr Ser His Ile  Tyr Gln Val 
        995                 1000                 1005             


Glu Phe  Glu Asp Gly Ser Gln  Leu Thr Val Lys Arg  Gly Asp Ile 
    1010                 1015                 1020             


Phe Thr  Leu Glu Glu Glu Leu  Pro Lys Arg Val Arg  Ser Arg Leu 
    1025                 1030                 1035             


Ser Leu  Ser Thr Gly Ala Pro  Gln Glu Pro Ala Phe  Ser Gly Glu 
    1040                 1045                 1050             


Glu Ala  Lys Ala Ala Lys Arg  Pro Arg Val Gly Thr  Pro Leu Ala 
    1055                 1060                 1065             


Thr Glu  Asp Ser Gly Arg Ser  Gln Asp Tyr Val Ala  Phe Val Glu 
    1070                 1075                 1080             


Ser Leu  Leu Gln Val Gln Gly  Arg Pro Gly Ala Pro  Phe 
    1085                 1090                 1095     


<210>  5810
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM4C__Homo_sapiens__NP_001140167

<400>  5810

Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn Pro Ser Cys Lys Ile 
1               5                   10                  15      


Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg Glu Phe Asn Lys Tyr 
            20                  25                  30          


Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg Ala Gly Leu Ala Lys 
        35                  40                  45              


Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Cys Tyr Asp Asp Ile 
    50                  55                  60                  


Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln Met Val Thr Gly Gln 
65                  70                  75                  80  


Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val 
                85                  90                  95      


Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys Tyr Cys Thr Pro Arg 
            100                 105                 110         


Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr 
        115                 120                 125             


Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn Gly Ser Ile Tyr Asp 
    130                 135                 140                 


Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Leu Asn Thr Val Leu Asp 
145                 150                 155                 160 


Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu Gly Val Asn Thr Pro 
                165                 170                 175     


Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu 
            180                 185                 190         


Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys 
        195                 200                 205             


Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu 
    210                 215                 220                 


Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly Cys Asp Ala Phe Leu 
225                 230                 235                 240 


Arg His Lys Met Thr Leu Ile Ser Pro Ser Val Leu Lys Lys Tyr Gly 
                245                 250                 255     


Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr 
            260                 265                 270         


Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala 
        275                 280                 285             


Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile Asp Tyr Gly Lys Val 
    290                 295                 300                 


Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp 
305                 310                 315                 320 


Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr Gln Leu Trp Lys Gln 
                325                 330                 335     


Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys Pro Thr Pro Ala Ser 
            340                 345                 350         


Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg Arg Lys Val Arg Lys 
        355                 360                 365             


Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr Ser Lys Arg Pro Lys 
    370                 375                 380                 


Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val Asp Gly Ala Glu Val 
385                 390                 395                 400 


Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys Val Ser Glu Lys Ser 
                405                 410                 415     


Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu 
            420                 425                 430         


Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn Leu Ser Asp His Ile 
        435                 440                 445             


Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser Val Thr Glu Asp Ile 
    450                 455                 460                 


Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg Ser Val Pro Ser Ile 
465                 470                 475                 480 


Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser Ser Gly Tyr Glu Lys 
                485                 490                 495     


Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp Pro Lys Ser Pro Glu 
            500                 505                 510         


Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val Leu Thr Glu Gly Glu 
        515                 520                 525             


Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu Glu Pro Gly Glu Ile 
    530                 535                 540                 


Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe Lys Val Pro Ser Ile 
545                 550                 555                 560 


Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp Arg His Pro Leu Ser 
                565                 570                 575     


Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val Lys Gln Gln Ala Pro 
            580                 585                 590         


Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile Glu Glu Glu Val Glu 
        595                 600                 605             


Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His Leu Trp Gln Thr Lys 
    610                 615                 620                 


Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn Ala Thr Val Ala Arg 
625                 630                 635                 640 


Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu Met Pro Tyr His Lys 
                645                 650                 655     


Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg Trp Glu Thr Lys Leu 
            660                 665                 670         


Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys Pro Leu Ile Pro Glu 
        675                 680                 685             


Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu Tyr Ser Pro Pro Asn 
    690                 695                 700                 


Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu Ile Ser Cys Ala Lys 
705                 710                 715                 720 


Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly Ile Pro Ser His Glu 
                725                 730                 735     


Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys Arg Asn Ala Trp Thr 
            740                 745                 750         


Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly Ala Leu Lys Gln Thr 
        755                 760                 765             


Lys Asn Asn Lys Trp Ala His Val Met Cys Ala Val Ala Val Pro Glu 
    770                 775                 780                 


Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln Ile Asp Val Gly Arg 
785                 790                 795                 800 


Ile Pro Leu Gln Arg Leu Lys Leu Gly Arg Leu Gly Ile 
                805                 810             


<210>  5811
<211>  1690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM5A__Homo_sapiens__NP_001036068

<400>  5811

Met Ala Gly Val Gly Pro Gly Gly Tyr Ala Ala Glu Phe Val Pro Pro 
1               5                   10                  15      


Pro Glu Cys Pro Val Phe Glu Pro Ser Trp Glu Glu Phe Thr Asp Pro 
            20                  25                  30          


Leu Ser Phe Ile Gly Arg Ile Arg Pro Leu Ala Glu Lys Thr Gly Ile 
        35                  40                  45              


Cys Lys Ile Arg Pro Pro Lys Asp Trp Gln Pro Pro Phe Ala Cys Glu 
    50                  55                  60                  


Val Lys Ser Phe Arg Phe Thr Pro Arg Val Gln Arg Leu Asn Glu Leu 
65                  70                  75                  80  


Glu Ala Met Thr Arg Val Arg Leu Asp Phe Leu Asp Gln Leu Ala Lys 
                85                  90                  95      


Phe Trp Glu Leu Gln Gly Ser Thr Leu Lys Ile Pro Val Val Glu Arg 
            100                 105                 110         


Lys Ile Leu Asp Leu Tyr Ala Leu Ser Lys Ile Val Ala Ser Lys Gly 
        115                 120                 125             


Gly Phe Glu Met Val Thr Lys Glu Lys Lys Trp Ser Lys Val Gly Ser 
    130                 135                 140                 


Arg Leu Gly Tyr Leu Pro Gly Lys Gly Thr Gly Ser Leu Leu Lys Ser 
145                 150                 155                 160 


His Tyr Glu Arg Ile Leu Tyr Pro Tyr Glu Leu Phe Gln Ser Gly Val 
                165                 170                 175     


Ser Leu Met Gly Val Gln Met Pro Asn Leu Asp Leu Lys Glu Lys Val 
            180                 185                 190         


Glu Pro Glu Val Leu Ser Thr Asp Thr Gln Thr Ser Pro Glu Pro Gly 
        195                 200                 205             


Thr Arg Met Asn Ile Leu Pro Lys Arg Thr Arg Arg Val Lys Thr Gln 
    210                 215                 220                 


Ser Glu Ser Gly Asp Val Ser Arg Asn Thr Glu Leu Lys Lys Leu Gln 
225                 230                 235                 240 


Ile Phe Gly Ala Gly Pro Lys Val Val Gly Leu Ala Met Gly Thr Lys 
                245                 250                 255     


Asp Lys Glu Asp Glu Val Thr Arg Arg Arg Lys Val Thr Asn Arg Ser 
            260                 265                 270         


Asp Ala Phe Asn Met Gln Met Arg Gln Arg Lys Gly Thr Leu Ser Val 
        275                 280                 285             


Asn Phe Val Asp Leu Tyr Val Cys Met Phe Cys Gly Arg Gly Asn Asn 
    290                 295                 300                 


Glu Asp Lys Leu Leu Leu Cys Asp Gly Cys Asp Asp Ser Tyr His Thr 
305                 310                 315                 320 


Phe Cys Leu Ile Pro Pro Leu Pro Asp Val Pro Lys Gly Asp Trp Arg 
                325                 330                 335     


Cys Pro Lys Cys Val Ala Glu Glu Cys Ser Lys Pro Arg Glu Ala Phe 
            340                 345                 350         


Gly Phe Glu Gln Ala Val Arg Glu Tyr Thr Leu Gln Ser Phe Gly Glu 
        355                 360                 365             


Met Ala Asp Asn Phe Lys Ser Asp Tyr Phe Asn Met Pro Val His Met 
    370                 375                 380                 


Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp Arg Leu Val Ser Ser 
385                 390                 395                 400 


Ile Glu Glu Asp Val Ile Val Glu Tyr Gly Ala Asp Ile Ser Ser Lys 
                405                 410                 415     


Asp Phe Gly Ser Gly Phe Pro Val Lys Asp Gly Arg Arg Lys Ile Leu 
            420                 425                 430         


Pro Glu Glu Glu Glu Tyr Ala Leu Ser Gly Trp Asn Leu Asn Asn Met 
        435                 440                 445             


Pro Val Leu Glu Gln Ser Val Leu Ala His Ile Asn Val Asp Ile Ser 
    450                 455                 460                 


Gly Met Lys Val Pro Trp Leu Tyr Val Gly Met Cys Phe Ser Ser Phe 
465                 470                 475                 480 


Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu His 
                485                 490                 495     


Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro Ser His Ala Ala Glu 
            500                 505                 510         


Gln Leu Glu Glu Val Met Arg Glu Leu Ala Pro Glu Leu Phe Glu Ser 
        515                 520                 525             


Gln Pro Asp Leu Leu His Gln Leu Val Thr Ile Met Asn Pro Asn Val 
    530                 535                 540                 


Leu Met Glu His Gly Val Pro Val Tyr Arg Thr Asn Gln Cys Ala Gly 
545                 550                 555                 560 


Glu Phe Val Val Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn Gln 
                565                 570                 575     


Gly Tyr Asn Phe Ala Glu Ala Val Asn Phe Cys Thr Ala Asp Trp Leu 
            580                 585                 590         


Pro Ile Gly Arg Gln Cys Val Asn His Tyr Arg Arg Leu Arg Arg His 
        595                 600                 605             


Cys Val Phe Ser His Glu Glu Leu Ile Phe Lys Met Ala Ala Asp Pro 
    610                 615                 620                 


Glu Cys Leu Asp Val Gly Leu Ala Ala Met Val Cys Lys Glu Leu Thr 
625                 630                 635                 640 


Leu Met Thr Glu Glu Glu Thr Arg Leu Arg Glu Ser Val Val Gln Met 
                645                 650                 655     


Gly Val Leu Met Ser Glu Glu Glu Val Phe Glu Leu Val Pro Asp Asp 
            660                 665                 670         


Glu Arg Gln Cys Ser Ala Cys Arg Thr Thr Cys Phe Leu Ser Ala Leu 
        675                 680                 685             


Thr Cys Ser Cys Asn Pro Glu Arg Leu Val Cys Leu Tyr His Pro Thr 
    690                 695                 700                 


Asp Leu Cys Pro Cys Pro Met Gln Lys Lys Cys Leu Arg Tyr Arg Tyr 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Pro Ser Leu Leu Tyr Gly Val Lys Val Arg Ala 
                725                 730                 735     


Gln Ser Tyr Asp Thr Trp Val Ser Arg Val Thr Glu Ala Leu Ser Ala 
            740                 745                 750         


Asn Phe Asn His Lys Lys Asp Leu Ile Glu Leu Arg Val Met Leu Glu 
        755                 760                 765             


Asp Ala Glu Asp Arg Lys Tyr Pro Glu Asn Asp Leu Phe Arg Lys Leu 
    770                 775                 780                 


Arg Asp Ala Val Lys Glu Ala Glu Thr Cys Ala Ser Val Ala Gln Leu 
785                 790                 795                 800 


Leu Leu Ser Lys Lys Gln Lys His Arg Gln Ser Pro Asp Ser Gly Arg 
                805                 810                 815     


Thr Arg Thr Lys Leu Thr Val Glu Glu Leu Lys Ala Phe Val Gln Gln 
            820                 825                 830         


Leu Phe Ser Leu Pro Cys Val Ile Ser Gln Ala Arg Gln Val Lys Asn 
        835                 840                 845             


Leu Leu Asp Asp Val Glu Glu Phe His Glu Arg Ala Gln Glu Ala Met 
    850                 855                 860                 


Met Asp Glu Thr Pro Asp Ser Ser Lys Leu Gln Met Leu Ile Asp Met 
865                 870                 875                 880 


Gly Ser Ser Leu Tyr Val Glu Leu Pro Glu Leu Pro Arg Leu Lys Gln 
                885                 890                 895     


Glu Leu Gln Gln Ala Arg Trp Leu Asp Glu Val Arg Leu Thr Leu Ser 
            900                 905                 910         


Asp Pro Gln Gln Val Thr Leu Asp Val Met Lys Lys Leu Ile Asp Ser 
        915                 920                 925             


Gly Val Gly Leu Ala Pro His His Ala Val Glu Lys Ala Met Ala Glu 
    930                 935                 940                 


Leu Gln Glu Leu Leu Thr Val Ser Glu Arg Trp Glu Glu Lys Ala Lys 
945                 950                 955                 960 


Val Cys Leu Gln Ala Arg Pro Arg His Ser Val Ala Ser Leu Glu Ser 
                965                 970                 975     


Ile Val Asn Glu Ala Lys Asn Ile Pro Ala Phe Leu Pro Asn Val Leu 
            980                 985                 990         


Ser Leu Lys Glu Ala Leu Gln Lys  Ala Arg Glu Trp Thr  Ala Lys Val 
        995                 1000                 1005             


Glu Ala  Ile Gln Ser Gly Ser  Asn Tyr Ala Tyr Leu  Glu Gln Leu 
    1010                 1015                 1020             


Glu Ser  Leu Ser Ala Lys Gly  Arg Pro Ile Pro Val  Arg Leu Glu 
    1025                 1030                 1035             


Ala Leu  Pro Gln Val Glu Ser  Gln Val Ala Ala Ala  Arg Ala Trp 
    1040                 1045                 1050             


Arg Glu  Arg Thr Gly Arg Thr  Phe Leu Lys Lys Asn  Ser Ser His 
    1055                 1060                 1065             


Thr Leu  Leu Gln Val Leu Ser  Pro Arg Thr Asp Ile  Gly Val Tyr 
    1070                 1075                 1080             


Gly Ser  Gly Lys Asn Arg Arg  Lys Lys Val Lys Glu  Leu Ile Glu 
    1085                 1090                 1095             


Lys Glu  Lys Glu Lys Asp Leu  Asp Leu Glu Pro Leu  Ser Asp Leu 
    1100                 1105                 1110             


Glu Glu  Gly Leu Glu Glu Thr  Arg Asp Thr Ala Met  Val Val Ala 
    1115                 1120                 1125             


Val Phe  Lys Glu Arg Glu Gln  Lys Glu Ile Glu Ala  Met His Ser 
    1130                 1135                 1140             


Leu Arg  Ala Ala Asn Leu Ala  Lys Met Thr Met Val  Asp Arg Ile 
    1145                 1150                 1155             


Glu Glu  Val Lys Phe Cys Ile  Cys Arg Lys Thr Ala  Ser Gly Phe 
    1160                 1165                 1170             


Met Leu  Gln Cys Glu Leu Cys  Lys Asp Trp Phe His  Asn Ser Cys 
    1175                 1180                 1185             


Val Pro  Leu Pro Lys Ser Ser  Ser Gln Lys Lys Gly  Ser Ser Trp 
    1190                 1195                 1200             


Gln Ala  Lys Glu Val Lys Phe  Leu Cys Pro Leu Cys  Met Arg Ser 
    1205                 1210                 1215             


Arg Arg  Pro Arg Leu Glu Thr  Ile Leu Ser Leu Leu  Val Ser Leu 
    1220                 1225                 1230             


Gln Lys  Leu Pro Val Arg Leu  Pro Glu Gly Glu Ala  Leu Gln Cys 
    1235                 1240                 1245             


Leu Thr  Glu Arg Ala Met Ser  Trp Gln Asp Arg Ala  Arg Gln Ala 
    1250                 1255                 1260             


Leu Ala  Thr Asp Glu Leu Ser  Ser Ala Leu Ala Lys  Leu Ser Val 
    1265                 1270                 1275             


Leu Ser  Gln Arg Met Val Glu  Gln Ala Ala Arg Glu  Lys Thr Glu 
    1280                 1285                 1290             


Lys Ile  Ile Ser Ala Glu Leu  Gln Lys Ala Ala Ala  Asn Pro Asp 
    1295                 1300                 1305             


Leu Gln  Gly His Leu Pro Ser  Phe Gln Gln Ser Ala  Phe Asn Arg 
    1310                 1315                 1320             


Val Val  Ser Ser Val Ser Ser  Ser Pro Arg Gln Thr  Met Asp Tyr 
    1325                 1330                 1335             


Asp Asp  Glu Glu Thr Asp Ser  Asp Glu Asp Ile Arg  Glu Thr Tyr 
    1340                 1345                 1350             


Gly Tyr  Asp Met Lys Asp Thr  Ala Ser Val Lys Ser  Ser Ser Ser 
    1355                 1360                 1365             


Leu Glu  Pro Asn Leu Phe Cys  Asp Glu Glu Ile Pro  Ile Lys Ser 
    1370                 1375                 1380             


Glu Glu  Val Val Thr His Met  Trp Thr Ala Pro Ser  Phe Cys Ala 
    1385                 1390                 1395             


Glu His  Ala Tyr Ser Ser Ala  Ser Lys Ser Cys Ser  Gln Gly Ser 
    1400                 1405                 1410             


Ser Thr  Pro Arg Lys Gln Pro  Arg Lys Ser Pro Leu  Val Pro Arg 
    1415                 1420                 1425             


Ser Leu  Glu Pro Pro Val Leu  Glu Leu Ser Pro Gly  Ala Lys Ala 
    1430                 1435                 1440             


Gln Leu  Glu Glu Leu Met Met  Val Gly Asp Leu Leu  Glu Val Ser 
    1445                 1450                 1455             


Leu Asp  Glu Thr Gln His Ile  Trp Arg Ile Leu Gln  Ala Thr His 
    1460                 1465                 1470             


Pro Pro  Ser Glu Asp Arg Phe  Leu His Ile Met Glu  Asp Asp Ser 
    1475                 1480                 1485             


Met Glu  Glu Lys Pro Leu Lys  Val Lys Gly Lys Asp  Ser Ser Glu 
    1490                 1495                 1500             


Lys Lys  Arg Lys Arg Lys Leu  Glu Lys Val Glu Gln  Leu Phe Gly 
    1505                 1510                 1515             


Glu Gly  Lys Gln Lys Ser Lys  Glu Leu Lys Lys Met  Asp Lys Pro 
    1520                 1525                 1530             


Arg Lys  Lys Lys Leu Lys Leu  Gly Ala Asp Lys Ser  Lys Glu Leu 
    1535                 1540                 1545             


Asn Lys  Leu Ala Lys Lys Leu  Ala Lys Glu Glu Glu  Arg Lys Lys 
    1550                 1555                 1560             


Lys Lys  Glu Lys Ala Ala Ala  Ala Lys Val Glu Leu  Val Lys Glu 
    1565                 1570                 1575             


Ser Thr  Glu Lys Lys Arg Glu  Lys Lys Val Leu Asp  Ile Pro Ser 
    1580                 1585                 1590             


Lys Tyr  Asp Trp Ser Gly Ala  Glu Glu Ser Asp Asp  Glu Asn Ala 
    1595                 1600                 1605             


Val Cys  Ala Ala Gln Asn Cys  Gln Arg Pro Cys Lys  Asp Lys Val 
    1610                 1615                 1620             


Asp Trp  Val Gln Cys Asp Gly  Gly Cys Asp Glu Trp  Phe His Gln 
    1625                 1630                 1635             


Val Cys  Val Gly Val Ser Pro  Glu Met Ala Glu Asn  Glu Asp Tyr 
    1640                 1645                 1650             


Ile Cys  Ile Asn Cys Ala Lys  Lys Gln Gly Pro Val  Ser Pro Gly 
    1655                 1660                 1665             


Pro Ala  Pro Pro Pro Ser Phe  Ile Met Ser Tyr Lys  Leu Pro Met 
    1670                 1675                 1680             


Glu Asp  Leu Lys Glu Thr Ser  
    1685                 1690 


<210>  5812
<211>  1544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM5B__Homo_sapiens__NP_006609

<400>  5812

Met Glu Ala Ala Thr Thr Leu His Pro Gly Pro Arg Pro Ala Leu Pro 
1               5                   10                  15      


Leu Gly Gly Pro Gly Pro Leu Gly Glu Phe Leu Pro Pro Pro Glu Cys 
            20                  25                  30          


Pro Val Phe Glu Pro Ser Trp Glu Glu Phe Ala Asp Pro Phe Ala Phe 
        35                  40                  45              


Ile His Lys Ile Arg Pro Ile Ala Glu Gln Thr Gly Ile Cys Lys Val 
    50                  55                  60                  


Arg Pro Pro Pro Asp Trp Gln Pro Pro Phe Ala Cys Asp Val Asp Lys 
65                  70                  75                  80  


Leu His Phe Thr Pro Arg Ile Gln Arg Leu Asn Glu Leu Glu Ala Gln 
                85                  90                  95      


Thr Arg Val Lys Leu Asn Phe Leu Asp Gln Ile Ala Lys Tyr Trp Glu 
            100                 105                 110         


Leu Gln Gly Ser Thr Leu Lys Ile Pro His Val Glu Arg Lys Ile Leu 
        115                 120                 125             


Asp Leu Phe Gln Leu Asn Lys Leu Val Ala Glu Glu Gly Gly Phe Ala 
    130                 135                 140                 


Val Val Cys Lys Asp Arg Lys Trp Thr Lys Ile Ala Thr Lys Met Gly 
145                 150                 155                 160 


Phe Ala Pro Gly Lys Ala Val Gly Ser His Ile Arg Gly His Tyr Glu 
                165                 170                 175     


Arg Ile Leu Asn Pro Tyr Asn Leu Phe Leu Ser Gly Asp Ser Leu Arg 
            180                 185                 190         


Cys Leu Gln Lys Pro Asn Leu Thr Thr Asp Thr Lys Asp Lys Glu Tyr 
        195                 200                 205             


Lys Pro His Asp Ile Pro Gln Arg Gln Ser Val Gln Pro Ser Glu Thr 
    210                 215                 220                 


Cys Pro Pro Ala Arg Arg Ala Lys Arg Met Arg Ala Glu Ala Met Asn 
225                 230                 235                 240 


Ile Lys Ile Glu Pro Glu Glu Thr Thr Glu Ala Arg Thr His Asn Leu 
                245                 250                 255     


Arg Arg Arg Met Gly Cys Pro Thr Pro Lys Cys Glu Asn Glu Lys Glu 
            260                 265                 270         


Met Lys Ser Ser Ile Lys Gln Glu Pro Ile Glu Arg Lys Asp Tyr Ile 
        275                 280                 285             


Val Glu Asn Glu Lys Glu Lys Pro Lys Ser Arg Ser Lys Lys Ala Thr 
    290                 295                 300                 


Asn Ala Val Asp Leu Tyr Val Cys Leu Leu Cys Gly Ser Gly Asn Asp 
305                 310                 315                 320 


Glu Asp Arg Leu Leu Leu Cys Asp Gly Cys Asp Asp Ser Tyr His Thr 
                325                 330                 335     


Phe Cys Leu Ile Pro Pro Leu His Asp Val Pro Lys Gly Asp Trp Arg 
            340                 345                 350         


Cys Pro Lys Cys Leu Ala Gln Glu Cys Ser Lys Pro Gln Glu Ala Phe 
        355                 360                 365             


Gly Phe Glu Gln Ala Ala Arg Asp Tyr Thr Leu Arg Thr Phe Gly Glu 
    370                 375                 380                 


Met Ala Asp Ala Phe Lys Ser Asp Tyr Phe Asn Met Pro Val His Met 
385                 390                 395                 400 


Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp Arg Leu Val Ser Thr 
                405                 410                 415     


Ile Glu Glu Asp Val Thr Val Glu Tyr Gly Ala Asp Ile Ala Ser Lys 
            420                 425                 430         


Glu Phe Gly Ser Gly Phe Pro Val Arg Asp Gly Lys Ile Lys Leu Ser 
        435                 440                 445             


Pro Glu Glu Glu Glu Tyr Leu Asp Ser Gly Trp Asn Leu Asn Asn Met 
    450                 455                 460                 


Pro Val Met Glu Gln Ser Val Leu Ala His Ile Thr Ala Asp Ile Cys 
465                 470                 475                 480 


Gly Met Lys Leu Pro Trp Leu Tyr Val Gly Met Cys Phe Ser Ser Phe 
                485                 490                 495     


Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu His 
            500                 505                 510         


Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro Gly Tyr Ala Ala Glu 
        515                 520                 525             


Gln Leu Glu Asn Val Met Lys Lys Leu Ala Pro Glu Leu Phe Val Ser 
    530                 535                 540                 


Gln Pro Asp Leu Leu His Gln Leu Val Thr Ile Met Asn Pro Asn Thr 
545                 550                 555                 560 


Leu Met Thr His Glu Val Pro Val Tyr Arg Thr Asn Gln Cys Ala Gly 
                565                 570                 575     


Glu Phe Val Ile Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn Gln 
            580                 585                 590         


Gly Phe Asn Phe Ala Glu Ala Val Asn Phe Cys Thr Val Asp Trp Leu 
        595                 600                 605             


Pro Leu Gly Arg Gln Cys Val Glu His Tyr Arg Leu Leu His Arg Tyr 
    610                 615                 620                 


Cys Val Phe Ser His Asp Glu Met Ile Cys Lys Met Ala Ser Lys Ala 
625                 630                 635                 640 


Asp Val Leu Asp Val Val Val Ala Ser Thr Val Gln Lys Asp Met Ala 
                645                 650                 655     


Ile Met Ile Glu Asp Glu Lys Ala Leu Arg Glu Thr Val Arg Lys Leu 
            660                 665                 670         


Gly Val Ile Asp Ser Glu Arg Met Asp Phe Glu Leu Leu Pro Asp Asp 
        675                 680                 685             


Glu Arg Gln Cys Val Lys Cys Lys Thr Thr Cys Phe Met Ser Ala Ile 
    690                 695                 700                 


Ser Cys Ser Cys Lys Pro Gly Leu Leu Val Cys Leu His His Val Lys 
705                 710                 715                 720 


Glu Leu Cys Ser Cys Pro Pro Tyr Lys Tyr Lys Leu Arg Tyr Arg Tyr 
                725                 730                 735     


Thr Leu Asp Asp Leu Tyr Pro Met Met Asn Ala Leu Lys Leu Arg Ala 
            740                 745                 750         


Glu Ser Tyr Asn Glu Trp Ala Leu Asn Val Asn Glu Ala Leu Glu Ala 
        755                 760                 765             


Lys Ile Asn Lys Lys Lys Ser Leu Val Ser Phe Lys Ala Leu Ile Glu 
    770                 775                 780                 


Glu Ser Glu Met Lys Lys Phe Pro Asp Asn Asp Leu Leu Arg His Leu 
785                 790                 795                 800 


Arg Leu Val Thr Gln Asp Ala Glu Lys Cys Ala Ser Val Ala Gln Gln 
                805                 810                 815     


Leu Leu Asn Gly Lys Arg Gln Thr Arg Tyr Arg Ser Gly Gly Gly Lys 
            820                 825                 830         


Ser Gln Asn Gln Leu Thr Val Asn Glu Leu Arg Gln Phe Val Thr Gln 
        835                 840                 845             


Leu Tyr Ala Leu Pro Cys Val Leu Ser Gln Thr Pro Leu Leu Lys Asp 
    850                 855                 860                 


Leu Leu Asn Arg Val Glu Asp Phe Gln Gln His Ser Gln Lys Leu Leu 
865                 870                 875                 880 


Ser Glu Glu Thr Pro Ser Ala Ala Glu Leu Gln Asp Leu Leu Asp Val 
                885                 890                 895     


Ser Phe Glu Phe Asp Val Glu Leu Pro Gln Leu Ala Glu Met Arg Ile 
            900                 905                 910         


Arg Leu Glu Gln Ala Arg Trp Leu Glu Glu Val Gln Gln Ala Cys Leu 
        915                 920                 925             


Asp Pro Ser Ser Leu Thr Leu Asp Asp Met Arg Arg Leu Ile Asp Leu 
    930                 935                 940                 


Gly Val Gly Leu Ala Pro Tyr Ser Ala Val Glu Lys Ala Met Ala Arg 
945                 950                 955                 960 


Leu Gln Glu Leu Leu Thr Val Ser Glu His Trp Asp Asp Lys Ala Lys 
                965                 970                 975     


Ser Leu Leu Lys Ala Arg Pro Arg His Ser Leu Asn Ser Leu Ala Thr 
            980                 985                 990         


Ala Val Lys Glu Ile Glu Glu Ile  Pro Ala Tyr Leu Pro  Asn Gly Ala 
        995                 1000                 1005             


Ala Leu  Lys Asp Ser Val Gln  Arg Ala Arg Asp Trp  Leu Gln Asp 
    1010                 1015                 1020             


Val Glu  Gly Leu Gln Ala Gly  Gly Arg Val Pro Val  Leu Asp Thr 
    1025                 1030                 1035             


Leu Ile  Glu Leu Val Thr Arg  Gly Arg Ser Ile Pro  Val His Leu 
    1040                 1045                 1050             


Asn Ser  Leu Pro Arg Leu Glu  Thr Leu Val Ala Glu  Val Gln Ala 
    1055                 1060                 1065             


Trp Lys  Glu Cys Ala Val Asn  Thr Phe Leu Thr Glu  Asn Ser Pro 
    1070                 1075                 1080             


Tyr Ser  Leu Leu Glu Val Leu  Cys Pro Arg Cys Asp  Ile Gly Leu 
    1085                 1090                 1095             


Leu Gly  Leu Lys Arg Lys Gln  Arg Lys Leu Lys Glu  Pro Leu Pro 
    1100                 1105                 1110             


Asn Gly  Lys Lys Lys Ser Thr  Lys Leu Glu Ser Leu  Ser Asp Leu 
    1115                 1120                 1125             


Glu Arg  Ala Leu Thr Glu Ser  Lys Glu Thr Ala Ser  Ala Met Ala 
    1130                 1135                 1140             


Thr Leu  Gly Glu Ala Arg Leu  Arg Glu Met Glu Ala  Leu Gln Ser 
    1145                 1150                 1155             


Leu Arg  Leu Ala Asn Glu Gly  Lys Leu Leu Ser Pro  Leu Gln Asp 
    1160                 1165                 1170             


Val Asp  Ile Lys Ile Cys Leu  Cys Gln Lys Ala Pro  Ala Ala Pro 
    1175                 1180                 1185             


Met Ile  Gln Cys Glu Leu Cys  Arg Asp Ala Phe His  Thr Ser Cys 
    1190                 1195                 1200             


Val Ala  Val Pro Ser Ile Ser  Gln Gly Leu Arg Ile  Trp Leu Cys 
    1205                 1210                 1215             


Pro His  Cys Arg Arg Ser Glu  Lys Pro Pro Leu Glu  Lys Ile Leu 
    1220                 1225                 1230             


Pro Leu  Leu Ala Ser Leu Gln  Arg Ile Arg Val Arg  Leu Pro Glu 
    1235                 1240                 1245             


Gly Asp  Ala Leu Arg Tyr Met  Ile Glu Arg Thr Val  Asn Trp Gln 
    1250                 1255                 1260             


His Arg  Ala Gln Gln Leu Leu  Ser Ser Gly Asn Leu  Lys Phe Val 
    1265                 1270                 1275             


Gln Asp  Arg Val Gly Ser Gly  Leu Leu Tyr Ser Arg  Trp Gln Ala 
    1280                 1285                 1290             


Ser Ala  Gly Gln Val Ser Asp  Thr Asn Lys Val Ser  Gln Pro Pro 
    1295                 1300                 1305             


Gly Thr  Thr Ser Phe Ser Leu  Pro Asp Asp Trp Asp  Asn Arg Thr 
    1310                 1315                 1320             


Ser Tyr  Leu His Ser Pro Phe  Ser Thr Gly Arg Ser  Cys Ile Pro 
    1325                 1330                 1335             


Leu His  Gly Val Ser Pro Glu  Val Asn Glu Leu Leu  Met Glu Ala 
    1340                 1345                 1350             


Gln Leu  Leu Gln Val Ser Leu  Pro Glu Ile Gln Glu  Leu Tyr Gln 
    1355                 1360                 1365             


Thr Leu  Leu Ala Lys Pro Ser  Pro Ala Gln Gln Thr  Asp Arg Ser 
    1370                 1375                 1380             


Ser Pro  Val Arg Pro Ser Ser  Glu Lys Asn Asp Cys  Cys Arg Gly 
    1385                 1390                 1395             


Lys Arg  Asp Gly Ile Asn Ser  Leu Glu Arg Lys Leu  Lys Arg Arg 
    1400                 1405                 1410             


Leu Glu  Arg Glu Gly Leu Ser  Ser Glu Arg Trp Glu  Arg Val Lys 
    1415                 1420                 1425             


Lys Met  Arg Thr Pro Lys Lys  Lys Lys Ile Lys Leu  Ser His Pro 
    1430                 1435                 1440             


Lys Asp  Met Asn Asn Phe Lys  Leu Glu Arg Glu Arg  Ser Tyr Glu 
    1445                 1450                 1455             


Leu Val  Arg Ser Ala Glu Thr  His Ser Leu Pro Ser  Asp Thr Ser 
    1460                 1465                 1470             


Tyr Ser  Glu Gln Glu Asp Ser  Glu Asp Glu Asp Ala  Ile Cys Pro 
    1475                 1480                 1485             


Ala Val  Ser Cys Leu Gln Pro  Glu Gly Asp Glu Val  Asp Trp Val 
    1490                 1495                 1500             


Gln Cys  Asp Gly Ser Cys Asn  Gln Trp Phe His Gln  Val Cys Val 
    1505                 1510                 1515             


Gly Val  Ser Pro Glu Met Ala  Glu Lys Glu Asp Tyr  Ile Cys Val 
    1520                 1525                 1530             


Arg Cys  Thr Val Lys Asp Ala  Pro Ser Arg Lys 
    1535                 1540                 


<210>  5813
<211>  1379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM5C__Homo_sapiens__NP_001140174

<400>  5813

Met Glu Pro Gly Ser Asp Asp Phe Leu Pro Pro Pro Glu Cys Pro Val 
1               5                   10                  15      


Phe Glu Pro Ser Trp Ala Glu Phe Arg Asp Pro Leu Gly Tyr Ile Ala 
            20                  25                  30          


Lys Ile Arg Pro Ile Ala Glu Lys Ser Gly Ile Cys Lys Ile Arg Pro 
        35                  40                  45              


Pro Ala Ile Val Val Glu Glu Gly Gly Tyr Glu Ala Ile Cys Lys Asp 
    50                  55                  60                  


Arg Arg Trp Ala Arg Val Ala Gln Arg Leu Asn Tyr Pro Pro Gly Lys 
65                  70                  75                  80  


Asn Ile Gly Ser Leu Leu Arg Ser His Tyr Glu Arg Ile Val Tyr Pro 
                85                  90                  95      


Tyr Glu Met Tyr Gln Ser Gly Ala Asn Leu Val Gln Cys Asn Thr Arg 
            100                 105                 110         


Pro Phe Asp Asn Glu Glu Lys Asp Lys Glu Tyr Lys Pro His Ser Ile 
        115                 120                 125             


Pro Leu Arg Gln Ser Val Gln Pro Ser Lys Phe Asn Ser Tyr Gly Arg 
    130                 135                 140                 


Arg Ala Lys Arg Leu Gln Pro Asp Pro Glu Pro Thr Glu Glu Asp Ile 
145                 150                 155                 160 


Glu Lys Asn Pro Glu Leu Lys Lys Leu Gln Ile Tyr Gly Ala Gly Pro 
                165                 170                 175     


Lys Met Met Gly Leu Gly Leu Met Ala Lys Asp Lys Thr Leu Arg Lys 
            180                 185                 190         


Lys Asp Lys Glu Gly Pro Glu Cys Pro Pro Thr Val Val Val Lys Glu 
        195                 200                 205             


Glu Leu Gly Gly Asp Val Lys Val Glu Ser Thr Ser Pro Lys Thr Phe 
    210                 215                 220                 


Leu Glu Ser Lys Glu Glu Leu Ser His Ser Pro Glu Pro Cys Thr Lys 
225                 230                 235                 240 


Met Thr Met Arg Leu Arg Arg Asn His Ser Asn Ala Gln Phe Ile Glu 
                245                 250                 255     


Ser Tyr Val Cys Arg Met Cys Ser Arg Gly Asp Glu Asp Asp Lys Leu 
            260                 265                 270         


Leu Leu Cys Asp Gly Cys Asp Asp Asn Tyr His Ile Phe Cys Leu Leu 
        275                 280                 285             


Pro Pro Leu Pro Glu Ile Pro Lys Gly Val Trp Arg Cys Pro Lys Cys 
    290                 295                 300                 


Val Met Ala Glu Cys Lys Arg Pro Pro Glu Ala Phe Gly Phe Glu Gln 
305                 310                 315                 320 


Ala Thr Arg Glu Tyr Thr Leu Gln Ser Phe Gly Glu Met Ala Asp Ser 
                325                 330                 335     


Phe Lys Ala Asp Tyr Phe Asn Met Pro Val His Met Val Pro Thr Glu 
            340                 345                 350         


Leu Val Glu Lys Glu Phe Trp Arg Leu Val Asn Ser Ile Glu Glu Asp 
        355                 360                 365             


Val Thr Val Glu Tyr Gly Ala Asp Ile His Ser Lys Glu Phe Gly Ser 
    370                 375                 380                 


Gly Phe Pro Val Ser Asp Ser Lys Arg His Leu Thr Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Tyr Ala Thr Ser Gly Trp Asn Leu Asn Val Met Pro Val Leu Glu 
                405                 410                 415     


Gln Ser Val Leu Cys His Ile Asn Ala Asp Ile Ser Gly Met Lys Val 
            420                 425                 430         


Pro Trp Leu Tyr Val Gly Met Val Phe Ser Ala Phe Cys Trp His Ile 
        435                 440                 445             


Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu His Trp Gly Glu Pro 
    450                 455                 460                 


Lys Thr Trp Tyr Gly Val Pro Ser Leu Ala Ala Glu His Leu Glu Glu 
465                 470                 475                 480 


Val Met Lys Lys Leu Thr Pro Glu Leu Phe Asp Ser Gln Pro Asp Leu 
                485                 490                 495     


Leu His Gln Leu Val Thr Leu Met Asn Pro Asn Thr Leu Met Ser His 
            500                 505                 510         


Gly Val Pro Val Val Arg Thr Asn Gln Cys Ala Gly Glu Phe Val Ile 
        515                 520                 525             


Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn Gln Gly Tyr Asn Phe 
    530                 535                 540                 


Ala Glu Ala Val Asn Phe Cys Thr Ala Asp Trp Leu Pro Ala Gly Arg 
545                 550                 555                 560 


Gln Cys Ile Glu His Tyr Arg Arg Leu Arg Arg Tyr Cys Val Phe Ser 
                565                 570                 575     


His Glu Glu Leu Ile Cys Lys Met Ala Ala Cys Pro Glu Lys Leu Asp 
            580                 585                 590         


Leu Asn Leu Ala Ala Ala Val His Lys Glu Met Phe Ile Met Val Gln 
        595                 600                 605             


Glu Glu Arg Arg Leu Arg Lys Ala Leu Leu Glu Lys Gly Ile Thr Glu 
    610                 615                 620                 


Ala Glu Arg Glu Ala Phe Glu Leu Leu Pro Asp Asp Glu Arg Gln Cys 
625                 630                 635                 640 


Ile Lys Cys Lys Thr Thr Cys Phe Leu Ser Ala Leu Ala Cys Tyr Asp 
                645                 650                 655     


Cys Pro Asp Gly Leu Val Cys Leu Ser His Ile Asn Asp Leu Cys Lys 
            660                 665                 670         


Cys Ser Ser Ser Arg Gln Tyr Leu Arg Tyr Arg Tyr Thr Leu Asp Glu 
        675                 680                 685             


Leu Pro Ala Met Leu His Lys Leu Lys Val Arg Ala Glu Ser Phe Asp 
    690                 695                 700                 


Thr Trp Ala Asn Lys Val Arg Val Ala Leu Glu Val Glu Asp Gly Arg 
705                 710                 715                 720 


Lys Arg Ser Leu Glu Glu Leu Arg Ala Leu Glu Ser Glu Ala Arg Glu 
                725                 730                 735     


Arg Arg Phe Pro Asn Ser Glu Leu Leu Gln Gln Leu Lys Asn Cys Leu 
            740                 745                 750         


Ser Glu Ala Glu Ala Cys Val Ser Arg Ala Leu Gly Leu Val Ser Gly 
        755                 760                 765             


Gln Glu Ala Gly Pro His Arg Val Ala Gly Leu Gln Met Thr Leu Thr 
    770                 775                 780                 


Glu Leu Arg Ala Phe Leu Asp Gln Met Asn Asn Leu Pro Cys Ala Met 
785                 790                 795                 800 


His Gln Ile Gly Asp Val Lys Gly Val Leu Glu Gln Val Glu Ala Tyr 
                805                 810                 815     


Gln Ala Glu Ala Arg Glu Ala Leu Ala Ser Leu Pro Ser Ser Pro Gly 
            820                 825                 830         


Leu Leu Gln Ser Leu Leu Glu Arg Gly Arg Gln Leu Gly Val Glu Val 
        835                 840                 845             


Pro Glu Ala Gln Gln Leu Gln Arg Gln Val Glu Gln Ala Arg Trp Leu 
    850                 855                 860                 


Asp Glu Val Lys Arg Thr Leu Ala Pro Ser Ala Arg Arg Gly Thr Leu 
865                 870                 875                 880 


Ala Val Met Arg Gly Leu Leu Val Ala Gly Ala Ser Val Ala Pro Ser 
                885                 890                 895     


Pro Ala Val Asp Lys Ala Gln Ala Glu Leu Gln Glu Leu Leu Thr Ile 
            900                 905                 910         


Ala Glu Arg Trp Glu Glu Lys Ala His Leu Cys Leu Glu Ala Arg Gln 
        915                 920                 925             


Lys His Pro Pro Ala Thr Leu Glu Ala Ile Ile Arg Glu Ala Glu Asn 
    930                 935                 940                 


Ile Pro Val His Leu Pro Asn Ile Gln Ala Leu Lys Glu Ala Leu Ala 
945                 950                 955                 960 


Lys Ala Arg Ala Trp Ile Ala Asp Val Asp Glu Ile Gln Asn Gly Asp 
                965                 970                 975     


His Tyr Pro Cys Leu Asp Asp Leu Glu Gly Leu Val Ala Val Gly Arg 
            980                 985                 990         


Asp Leu Pro Val Gly Leu Glu Glu  Leu Arg Gln Leu Glu  Leu Gln Val 
        995                 1000                 1005             


Leu Thr  Ala His Ser Trp Arg  Glu Lys Ala Ser Lys  Thr Phe Leu 
    1010                 1015                 1020             


Lys Lys  Asn Ser Cys Tyr Thr  Leu Leu Glu Val Leu  Cys Pro Cys 
    1025                 1030                 1035             


Ala Asp  Ala Gly Ser Asp Ser  Thr Lys Arg Ser Arg  Trp Met Glu 
    1040                 1045                 1050             


Lys Glu  Leu Gly Leu Tyr Lys  Ser Asp Thr Glu Leu  Leu Gly Leu 
    1055                 1060                 1065             


Ser Ala  Gln Asp Leu Arg Asp  Pro Gly Ser Val Ile  Val Ala Phe 
    1070                 1075                 1080             


Lys Glu  Gly Glu Gln Lys Glu  Lys Glu Gly Ile Leu  Gln Leu Arg 
    1085                 1090                 1095             


Arg Thr  Asn Ser Ala Lys Pro  Ser Pro Leu Ala Ser  Ser Ser Thr 
    1100                 1105                 1110             


Ala Ser  Ser Thr Thr Ser Ile  Cys Val Cys Gly Gln  Val Leu Ala 
    1115                 1120                 1125             


Gly Ala  Gly Ala Leu Gln Cys  Asp Leu Cys Gln Asp  Trp Phe His 
    1130                 1135                 1140             


Gly Arg  Cys Val Ser Val Pro  Arg Leu Leu Ser Ser  Pro Arg Pro 
    1145                 1150                 1155             


Asn Pro  Thr Ser Ser Pro Leu  Leu Ala Trp Trp Glu  Trp Asp Thr 
    1160                 1165                 1170             


Lys Phe  Leu Cys Pro Leu Cys  Met Arg Ser Arg Arg  Pro Arg Leu 
    1175                 1180                 1185             


Glu Thr  Ile Leu Ala Leu Leu  Val Ala Leu Gln Arg  Leu Pro Val 
    1190                 1195                 1200             


Arg Leu  Pro Glu Gly Glu Ala  Leu Gln Cys Leu Thr  Glu Arg Ala 
    1205                 1210                 1215             


Ile Ser  Trp Gln Gly Arg Ala  Arg Gln Ala Leu Ala  Ser Glu Asp 
    1220                 1225                 1230             


Val Thr  Ala Leu Leu Gly Arg  Leu Ala Glu Leu Arg  Gln Arg Leu 
    1235                 1240                 1245             


Gln Ala  Glu Pro Arg Pro Glu  Glu Pro Pro Asn Tyr  Pro Ala Ala 
    1250                 1255                 1260             


Pro Ala  Ser Asp Pro Leu Arg  Glu Gly Ser Gly Lys  Asp Met Pro 
    1265                 1270                 1275             


Lys Val  Gln Gly Leu Leu Glu  Asn Gly Asp Ser Val  Thr Ser Pro 
    1280                 1285                 1290             


Glu Lys  Val Ala Pro Glu Glu  Gly Ser Asp Leu Glu  Leu Leu Ser 
    1295                 1300                 1305             


Ser Leu  Leu Pro Gln Leu Thr  Gly Pro Val Leu Glu  Leu Pro Glu 
    1310                 1315                 1320             


Ala Thr  Arg Ala Pro Leu Glu  Glu Leu Met Met Glu  Gly Asp Leu 
    1325                 1330                 1335             


Leu Glu  Val Thr Leu Asp Glu  Asn His Ser Ile Pro  Glu Ser Leu 
    1340                 1345                 1350             


Asp Phe  Cys Ile Leu Thr Pro  Arg Tyr Cys Ser Asp  Leu Ser Ser 
    1355                 1360                 1365             


Trp Gly  Pro Ala Pro Gly Val  Phe Pro Pro Trp 
    1370                 1375                 


<210>  5814
<211>  1570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM5D__Homo_sapiens__NP_001140177

<400>  5814

Met Glu Pro Gly Cys Asp Glu Phe Leu Pro Pro Pro Glu Cys Pro Val 
1               5                   10                  15      


Phe Glu Pro Ser Trp Ala Glu Phe Gln Asp Pro Leu Gly Tyr Ile Ala 
            20                  25                  30          


Lys Ile Arg Pro Ile Ala Glu Lys Ser Gly Ile Cys Lys Ile Arg Pro 
        35                  40                  45              


Pro Ala Asp Trp Gln Pro Pro Phe Ala Val Glu Val Asp Asn Phe Arg 
    50                  55                  60                  


Phe Thr Pro Arg Val Gln Arg Leu Asn Glu Leu Glu Ala Gln Thr Arg 
65                  70                  75                  80  


Val Lys Leu Asn Tyr Leu Asp Gln Ile Ala Lys Phe Trp Glu Ile Gln 
                85                  90                  95      


Gly Ser Ser Leu Lys Ile Pro Asn Val Glu Arg Lys Ile Leu Asp Leu 
            100                 105                 110         


Tyr Ser Leu Ser Lys Ile Val Ile Glu Glu Gly Gly Tyr Glu Ala Ile 
        115                 120                 125             


Cys Lys Asp Arg Arg Trp Ala Arg Val Ala Gln Arg Leu His Tyr Pro 
    130                 135                 140                 


Pro Gly Lys Asn Ile Gly Ser Leu Leu Arg Ser His Tyr Glu Arg Ile 
145                 150                 155                 160 


Ile Tyr Pro Tyr Glu Met Phe Gln Ser Gly Ala Asn His Val Gln Cys 
                165                 170                 175     


Asn Thr His Pro Phe Asp Asn Glu Val Lys Asp Lys Glu Tyr Lys Pro 
            180                 185                 190         


His Ser Ile Pro Leu Arg Gln Ser Val Gln Pro Ser Lys Phe Ser Ser 
        195                 200                 205             


Tyr Ser Arg Arg Ala Lys Arg Leu Gln Pro Asp Pro Glu Pro Thr Glu 
    210                 215                 220                 


Glu Asp Ile Glu Lys His Pro Glu Leu Lys Lys Leu Gln Ile Tyr Gly 
225                 230                 235                 240 


Pro Gly Pro Lys Met Met Gly Leu Gly Leu Met Ala Lys Asp Lys Asp 
                245                 250                 255     


Lys Thr Val His Lys Lys Val Thr Cys Pro Pro Thr Val Thr Val Lys 
            260                 265                 270         


Asp Glu Gln Ser Gly Gly Gly Asn Val Ser Ser Thr Leu Leu Lys Gln 
        275                 280                 285             


His Leu Ser Leu Glu Pro Cys Thr Lys Thr Thr Met Gln Leu Arg Lys 
    290                 295                 300                 


Asn His Ser Ser Ala Gln Phe Ile Asp Ser Tyr Ile Cys Gln Val Cys 
305                 310                 315                 320 


Ser Arg Gly Asp Glu Asp Asp Lys Leu Leu Phe Cys Asp Gly Cys Asp 
                325                 330                 335     


Asp Asn Tyr His Ile Phe Cys Leu Leu Pro Pro Leu Pro Glu Ile Pro 
            340                 345                 350         


Arg Gly Ile Trp Arg Cys Pro Lys Cys Ile Leu Ala Glu Cys Lys Gln 
        355                 360                 365             


Pro Pro Glu Ala Phe Gly Phe Glu Gln Ala Thr Gln Glu Tyr Ser Leu 
    370                 375                 380                 


Gln Ser Phe Gly Glu Met Ala Asp Ser Phe Lys Ser Asp Tyr Phe Asn 
385                 390                 395                 400 


Met Pro Val His Met Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp 
                405                 410                 415     


Arg Leu Val Ser Ser Ile Glu Glu Asp Val Thr Val Glu Tyr Gly Ala 
            420                 425                 430         


Asp Ile His Ser Lys Glu Phe Gly Ser Gly Phe Pro Val Ser Asn Ser 
        435                 440                 445             


Lys Gln Asn Leu Ser Pro Glu Glu Lys Arg Gln Ser Leu Thr Val Leu 
    450                 455                 460                 


Thr Arg Leu Ile Ser Ser Phe Trp Ala Gln Ala Val Leu Pro Pro Trp 
465                 470                 475                 480 


Pro Pro Lys Val Leu Gly Leu Gln Glu Tyr Ala Thr Ser Gly Trp Asn 
                485                 490                 495     


Leu Asn Val Met Pro Val Leu Asp Gln Ser Val Leu Cys His Ile Asn 
            500                 505                 510         


Ala Asp Ile Ser Gly Met Lys Val Pro Trp Leu Tyr Val Gly Met Val 
        515                 520                 525             


Phe Ser Ala Phe Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser Ile 
    530                 535                 540                 


Asn Tyr Leu His Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro Ser 
545                 550                 555                 560 


Leu Ala Ala Glu His Leu Glu Glu Val Met Lys Met Leu Thr Pro Glu 
                565                 570                 575     


Leu Phe Asp Ser Gln Pro Asp Leu Leu His Gln Leu Val Thr Leu Met 
            580                 585                 590         


Asn Pro Asn Thr Leu Met Ser His Gly Val Pro Val Val Arg Thr Asn 
        595                 600                 605             


Gln Cys Ala Gly Glu Phe Val Ile Thr Phe Pro Arg Ala Tyr His Ser 
    610                 615                 620                 


Gly Phe Asn Gln Gly Tyr Asn Phe Ala Glu Ala Val Asn Phe Cys Thr 
625                 630                 635                 640 


Ala Asp Trp Leu Pro Ala Gly Arg Gln Cys Ile Glu His Tyr Arg Arg 
                645                 650                 655     


Leu Arg Arg Tyr Cys Val Phe Ser His Glu Glu Leu Ile Cys Lys Met 
            660                 665                 670         


Ala Ala Phe Pro Glu Thr Leu Asp Leu Asn Leu Ala Val Ala Val His 
        675                 680                 685             


Lys Glu Met Phe Ile Met Val Gln Glu Glu Arg Arg Leu Arg Lys Ala 
    690                 695                 700                 


Leu Leu Glu Lys Gly Val Thr Glu Ala Glu Arg Glu Ala Phe Glu Leu 
705                 710                 715                 720 


Leu Pro Asp Asp Glu Arg Gln Cys Ile Lys Cys Lys Thr Thr Cys Phe 
                725                 730                 735     


Leu Ser Ala Leu Ala Cys Tyr Asp Cys Pro Asp Gly Leu Val Cys Leu 
            740                 745                 750         


Ser His Ile Asn Asp Leu Cys Lys Cys Ser Ser Ser Arg Gln Tyr Leu 
        755                 760                 765             


Arg Tyr Arg Tyr Thr Leu Asp Glu Leu Pro Thr Met Leu His Lys Leu 
    770                 775                 780                 


Lys Ile Arg Ala Glu Ser Phe Asp Thr Trp Ala Asn Lys Val Arg Val 
785                 790                 795                 800 


Ala Leu Glu Val Glu Asp Gly Arg Lys Arg Ser Phe Glu Glu Leu Arg 
                805                 810                 815     


Ala Leu Glu Ser Glu Ala Arg Glu Arg Arg Phe Pro Asn Ser Glu Leu 
            820                 825                 830         


Leu Gln Arg Leu Lys Asn Cys Leu Ser Glu Val Glu Ala Cys Ile Ala 
        835                 840                 845             


Gln Val Leu Gly Leu Val Ser Gly Gln Val Ala Arg Met Asp Thr Pro 
    850                 855                 860                 


Gln Leu Thr Leu Thr Glu Leu Arg Val Leu Leu Glu Gln Met Gly Ser 
865                 870                 875                 880 


Leu Pro Cys Ala Met His Gln Ile Gly Asp Val Lys Asp Val Leu Glu 
                885                 890                 895     


Gln Val Glu Ala Tyr Gln Ala Glu Ala Arg Glu Ala Leu Ala Thr Leu 
            900                 905                 910         


Pro Ser Ser Pro Gly Leu Leu Arg Ser Leu Leu Glu Arg Gly Gln Gln 
        915                 920                 925             


Leu Gly Val Glu Val Pro Glu Ala His Gln Leu Gln Gln Gln Val Glu 
    930                 935                 940                 


Gln Ala Gln Trp Leu Asp Glu Val Lys Gln Ala Leu Ala Pro Ser Ala 
945                 950                 955                 960 


His Arg Gly Ser Leu Val Ile Met Gln Gly Leu Leu Val Met Gly Ala 
                965                 970                 975     


Lys Ile Ala Ser Ser Pro Ser Val Asp Lys Ala Arg Ala Glu Leu Gln 
            980                 985                 990         


Glu Leu Leu Thr Ile Ala Glu Arg  Trp Glu Glu Lys Ala  His Phe Cys 
        995                 1000                 1005             


Leu Glu  Ala Arg Gln Lys His  Pro Pro Ala Thr Leu  Glu Ala Ile 
    1010                 1015                 1020             


Ile Arg  Glu Thr Glu Asn Ile  Pro Val His Leu Pro  Asn Ile Gln 
    1025                 1030                 1035             


Ala Leu  Lys Glu Ala Leu Thr  Lys Ala Gln Ala Trp  Ile Ala Asp 
    1040                 1045                 1050             


Val Asp  Glu Ile Gln Asn Gly  Asp His Tyr Pro Cys  Leu Asp Asp 
    1055                 1060                 1065             


Leu Glu  Gly Leu Val Ala Val  Gly Arg Asp Leu Pro  Val Gly Leu 
    1070                 1075                 1080             


Glu Glu  Leu Arg Gln Leu Glu  Leu Gln Val Leu Thr  Ala His Ser 
    1085                 1090                 1095             


Trp Arg  Glu Lys Ala Ser Lys  Thr Phe Leu Lys Lys  Asn Ser Cys 
    1100                 1105                 1110             


Tyr Thr  Leu Leu Glu Val Leu  Cys Pro Cys Ala Asp  Ala Gly Ser 
    1115                 1120                 1125             


Asp Ser  Thr Lys Arg Ser Arg  Trp Met Glu Lys Ala  Leu Gly Leu 
    1130                 1135                 1140             


Tyr Gln  Cys Asp Thr Glu Leu  Leu Gly Leu Ser Ala  Gln Asp Leu 
    1145                 1150                 1155             


Arg Asp  Pro Gly Ser Val Ile  Val Ala Phe Lys Glu  Gly Glu Gln 
    1160                 1165                 1170             


Lys Glu  Lys Glu Gly Ile Leu  Gln Leu Arg Arg Thr  Asn Ser Ala 
    1175                 1180                 1185             


Lys Pro  Ser Pro Leu Ala Pro  Ser Leu Met Ala Ser  Ser Pro Thr 
    1190                 1195                 1200             


Ser Ile  Cys Val Cys Gly Gln  Val Pro Ala Gly Val  Gly Val Leu 
    1205                 1210                 1215             


Gln Cys  Asp Leu Cys Gln Asp  Trp Phe His Gly Gln  Cys Val Ser 
    1220                 1225                 1230             


Val Pro  His Leu Leu Thr Ser  Pro Lys Pro Ser Leu  Thr Ser Ser 
    1235                 1240                 1245             


Pro Leu  Leu Ala Trp Trp Glu  Trp Asp Thr Lys Phe  Leu Cys Pro 
    1250                 1255                 1260             


Leu Cys  Met Arg Ser Arg Arg  Pro Arg Leu Glu Thr  Ile Leu Ala 
    1265                 1270                 1275             


Leu Leu  Val Ala Leu Gln Arg  Leu Pro Val Arg Leu  Pro Glu Gly 
    1280                 1285                 1290             


Glu Ala  Leu Gln Cys Leu Thr  Glu Arg Ala Ile Gly  Trp Gln Asp 
    1295                 1300                 1305             


Arg Ala  Arg Lys Ala Leu Ala  Ser Glu Asp Val Thr  Ala Leu Leu 
    1310                 1315                 1320             


Arg Gln  Leu Ala Glu Leu Arg  Gln Gln Leu Gln Ala  Lys Pro Arg 
    1325                 1330                 1335             


Pro Glu  Glu Ala Ser Val Tyr  Thr Ser Ala Thr Ala  Cys Asp Pro 
    1340                 1345                 1350             


Ile Arg  Glu Gly Ser Gly Asn  Asn Ile Ser Lys Val  Gln Gly Leu 
    1355                 1360                 1365             


Leu Glu  Asn Gly Asp Ser Val  Thr Ser Pro Glu Asn  Met Ala Pro 
    1370                 1375                 1380             


Gly Lys  Gly Ser Asp Leu Glu  Leu Leu Ser Ser Leu  Leu Pro Gln 
    1385                 1390                 1395             


Leu Thr  Gly Pro Val Leu Glu  Leu Pro Glu Ala Ile  Arg Ala Pro 
    1400                 1405                 1410             


Leu Glu  Glu Leu Met Met Glu  Gly Asp Leu Leu Glu  Val Thr Leu 
    1415                 1420                 1425             


Asp Glu  Asn His Ser Ile Trp  Gln Leu Leu Gln Ala  Gly Gln Pro 
    1430                 1435                 1440             


Pro Asp  Leu Asp Arg Ile Arg  Thr Leu Leu Glu Leu  Glu Lys Phe 
    1445                 1450                 1455             


Glu His  Gln Gly Ser Arg Thr  Arg Ser Arg Ala Leu  Glu Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Gln Lys Val Asp  Gln Gly Arg Asn Val  Glu Asn Leu 
    1475                 1480                 1485             


Val Gln  Gln Glu Leu Gln Ser  Lys Arg Ala Arg Ser  Ser Gly Ile 
    1490                 1495                 1500             


Met Ser  Gln Val Gly Arg Glu  Glu Glu His Tyr Gln  Glu Lys Ala 
    1505                 1510                 1515             


Asp Arg  Glu Asn Met Phe Leu  Thr Pro Ser Thr Asp  His Ser Pro 
    1520                 1525                 1530             


Phe Leu  Lys Gly Asn Gln Asn  Ser Leu Gln His Lys  Asp Ser Gly 
    1535                 1540                 1545             


Ser Ser  Ala Ala Cys Pro Ser  Leu Met Pro Leu Leu  Gln Leu Ser 
    1550                 1555                 1560             


Tyr Ser  Asp Glu Gln Gln Leu  
    1565                 1570 


<210>  5815
<211>  1453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM6A__Homo_sapiens__NP_001278344

<400>  5815

Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly 
            20                  25                  30          


Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala 
        35                  40                  45              


Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu 
    50                  55                  60                  


Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr 
65                  70                  75                  80  


Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe 
                85                  90                  95      


Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala 
            100                 105                 110         


Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys 
        115                 120                 125             


Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn 
    130                 135                 140                 


Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp 
145                 150                 155                 160 


Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met 
                165                 170                 175     


Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu 
            180                 185                 190         


Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln 
        195                 200                 205             


Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala 
    210                 215                 220                 


Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln 
225                 230                 235                 240 


Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val 
                245                 250                 255     


Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr 
            260                 265                 270         


Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr 
        275                 280                 285             


Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe 
    290                 295                 300                 


Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr 
305                 310                 315                 320 


Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp 
                325                 330                 335     


Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala 
            340                 345                 350         


Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro 
        355                 360                 365             


Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys 
    370                 375                 380                 


Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln 
385                 390                 395                 400 


Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu 
                405                 410                 415     


Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr 
            420                 425                 430         


Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Ala Cys Lys Pro His 
        435                 440                 445             


His Pro Asn Thr Glu Pro Val Leu Gly Leu Ser Gln Thr Pro Ile Ser 
    450                 455                 460                 


Gln Gln Ser Leu Pro Leu His Met Ile Pro Ser Ser Gln Val Asp Asp 
465                 470                 475                 480 


Leu Ser Ser Pro Ala Lys Arg Lys Arg Thr Ser Ser Pro Thr Lys Asn 
                485                 490                 495     


Thr Ser Asp Asn Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val 
            500                 505                 510         


Gln Gln Gln Ala His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His 
        515                 520                 525             


Leu Glu Gln Leu Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys 
    530                 535                 540                 


Leu Met Leu Glu Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His 
545                 550                 555                 560 


Gln Met Arg Pro Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro 
                565                 570                 575     


Asn Gly Pro Thr Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly 
            580                 585                 590         


Gln Gln Pro Gln Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro 
        595                 600                 605             


Gly Val Arg Pro Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe 
    610                 615                 620                 


Ser Ala Gly His Val Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr 
625                 630                 635                 640 


Asp Thr Ile Leu Ile Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn 
                645                 650                 655     


Gly Asn Val Pro Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn 
            660                 665                 670         


Arg Thr Asn Leu Thr Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu 
        675                 680                 685             


Ser Asn Ser Thr Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala 
    690                 695                 700                 


Gly Pro Asn Gly Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His 
705                 710                 715                 720 


Leu Gln Ala Ala Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr 
                725                 730                 735     


Leu Pro Ser Asn Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser 
            740                 745                 750         


Ser His Thr Ala Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys 
        755                 760                 765             


Glu Ser Lys Pro Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg 
    770                 775                 780                 


His Thr Gly Glu Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro 
785                 790                 795                 800 


Asn His Val His Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His 
                805                 810                 815     


Gly Asp Ser Lys Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu 
            820                 825                 830         


Ser Ala Leu Leu Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr 
        835                 840                 845             


Cys Asp Lys Val Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp 
    850                 855                 860                 


Asn Ser Val Ala Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro 
865                 870                 875                 880 


Ser Pro Lys Ser Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu 
                885                 890                 895     


Asn Ser Pro His Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu 
            900                 905                 910         


Glu Ser Gln Ser Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys 
        915                 920                 925             


Pro Ser Pro Gln Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser 
    930                 935                 940                 


Ser Ala Glu Val Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu 
945                 950                 955                 960 


Ser Asn Ser Ser Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro 
                965                 970                 975     


Ser Ser Pro Tyr Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr 
            980                 985                 990         


Pro Ser Ile Tyr Leu Glu Asn Lys  Arg Asp Ala Phe Phe  Pro Pro Leu 
        995                 1000                 1005             


His Gln  Phe Cys Thr Asn Pro  Asn Asn Pro Val Thr  Val Ile Arg 
    1010                 1015                 1020             


Gly Leu  Ala Gly Ala Leu Lys  Leu Asp Leu Gly Leu  Phe Ser Thr 
    1025                 1030                 1035             


Lys Thr  Leu Val Glu Ala Asn  Asn Glu His Met Val  Glu Val Arg 
    1040                 1045                 1050             


Thr Gln  Leu Leu Gln Pro Ala  Asp Glu Asn Trp Asp  Pro Thr Gly 
    1055                 1060                 1065             


Thr Lys  Lys Ile Trp His Cys  Glu Ser Asn Arg Ser  His Thr Thr 
    1070                 1075                 1080             


Ile Ala  Lys Tyr Ala Gln Tyr  Gln Ala Ser Ser Phe  Gln Glu Ser 
    1085                 1090                 1095             


Leu Arg  Glu Glu Asn Glu Lys  Arg Ser His His Lys  Asp His Ser 
    1100                 1105                 1110             


Asp Ser  Glu Ser Thr Ser Ser  Asp Asn Ser Gly Arg  Arg Arg Lys 
    1115                 1120                 1125             


Gly Pro  Phe Lys Thr Ile Lys  Phe Gly Thr Asn Ile  Asp Leu Ser 
    1130                 1135                 1140             


Asp Asp  Lys Lys Trp Lys Leu  Gln Leu His Glu Leu  Thr Lys Leu 
    1145                 1150                 1155             


Pro Ala  Phe Val Arg Val Val  Ser Ala Gly Asn Leu  Leu Ser His 
    1160                 1165                 1170             


Val Gly  His Thr Ile Leu Gly  Met Asn Thr Val Gln  Leu Tyr Met 
    1175                 1180                 1185             


Lys Val  Pro Gly Ser Arg Thr  Pro Gly His Gln Glu  Asn Asn Asn 
    1190                 1195                 1200             


Phe Cys  Ser Val Asn Ile Asn  Ile Gly Pro Gly Asp  Cys Glu Trp 
    1205                 1210                 1215             


Phe Val  Val Pro Glu Gly Tyr  Trp Gly Val Leu Asn  Asp Phe Cys 
    1220                 1225                 1230             


Glu Lys  Asn Asn Leu Asn Phe  Leu Met Gly Ser Trp  Trp Pro Asn 
    1235                 1240                 1245             


Leu Glu  Asp Leu Tyr Glu Ala  Asn Val Pro Val Tyr  Arg Phe Ile 
    1250                 1255                 1260             


Gln Arg  Pro Gly Asp Leu Val  Trp Ile Asn Ala Gly  Thr Val His 
    1265                 1270                 1275             


Trp Val  Gln Ala Ile Gly Trp  Cys Asn Asn Ile Ala  Trp Asn Val 
    1280                 1285                 1290             


Gly Pro  Leu Thr Ala Cys Gln  Tyr Lys Leu Ala Val  Glu Arg Tyr 
    1295                 1300                 1305             


Glu Trp  Asn Lys Leu Gln Ser  Val Lys Ser Ile Val  Pro Met Val 
    1310                 1315                 1320             


His Leu  Ser Trp Asn Met Ala  Arg Asn Ile Lys Val  Ser Asp Pro 
    1325                 1330                 1335             


Lys Leu  Phe Glu Met Ile Lys  Tyr Cys Leu Leu Arg  Thr Leu Lys 
    1340                 1345                 1350             


Gln Cys  Gln Thr Leu Arg Glu  Ala Leu Ile Ala Ala  Gly Lys Glu 
    1355                 1360                 1365             


Ile Ile  Trp His Gly Arg Thr  Lys Glu Glu Pro Ala  His Tyr Cys 
    1370                 1375                 1380             


Ser Ile  Cys Glu Val Glu Val  Phe Asp Leu Leu Phe  Val Thr Asn 
    1385                 1390                 1395             


Glu Ser  Asn Ser Arg Lys Thr  Tyr Ile Val His Cys  Gln Asp Cys 
    1400                 1405                 1410             


Ala Arg  Lys Thr Ser Gly Asn  Leu Glu Asn Phe Val  Val Leu Glu 
    1415                 1420                 1425             


Gln Tyr  Lys Met Glu Asp Leu  Met Gln Val Tyr Asp  Gln Phe Thr 
    1430                 1435                 1440             


Leu Ala  Pro Pro Leu Pro Ser  Ala Ser Ser 
    1445                 1450             


<210>  5816
<211>  1682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDM6B__Homo_sapiens__NP_001073893

<400>  5816

Met His Arg Ala Val Asp Pro Pro Gly Ala Arg Ala Ala Arg Glu Ala 
1               5                   10                  15      


Phe Ala Leu Gly Gly Leu Ser Cys Ala Gly Ala Trp Ser Ser Cys Pro 
            20                  25                  30          


Pro His Pro Pro Pro Arg Ser Ala Trp Leu Pro Gly Gly Arg Cys Ser 
        35                  40                  45              


Ala Ser Ile Gly Gln Pro Pro Leu Pro Ala Pro Leu Pro Pro Ser His 
    50                  55                  60                  


Gly Ser Ser Ser Gly His Pro Ser Lys Pro Tyr Tyr Ala Pro Gly Ala 
65                  70                  75                  80  


Pro Thr Pro Arg Pro Leu His Gly Lys Leu Glu Ser Leu His Gly Cys 
                85                  90                  95      


Val Gln Ala Leu Leu Arg Glu Pro Ala Gln Pro Gly Leu Trp Glu Gln 
            100                 105                 110         


Leu Gly Gln Leu Tyr Glu Ser Glu His Asp Ser Glu Glu Ala Thr Arg 
        115                 120                 125             


Cys Tyr His Ser Ala Leu Arg Tyr Gly Gly Ser Phe Ala Glu Leu Gly 
    130                 135                 140                 


Pro Arg Ile Gly Arg Leu Gln Gln Ala Gln Leu Trp Asn Phe His Thr 
145                 150                 155                 160 


Gly Ser Cys Gln His Arg Ala Lys Val Leu Pro Pro Leu Glu Gln Val 
                165                 170                 175     


Trp Asn Leu Leu His Leu Glu His Lys Arg Asn Tyr Gly Ala Lys Arg 
            180                 185                 190         


Gly Gly Pro Pro Val Lys Arg Ala Ala Glu Pro Pro Val Val Gln Pro 
        195                 200                 205             


Val Pro Pro Ala Ala Leu Ser Gly Pro Ser Gly Glu Glu Gly Leu Ser 
    210                 215                 220                 


Pro Gly Gly Lys Arg Arg Arg Gly Cys Asn Ser Glu Gln Thr Gly Leu 
225                 230                 235                 240 


Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Leu Ala Thr Ser Pro 
            260                 265                 270         


Pro Phe Gln Leu Thr Lys Pro Gly Leu Trp Ser Thr Leu His Gly Asp 
        275                 280                 285             


Ala Trp Gly Pro Glu Arg Lys Gly Ser Ala Pro Pro Glu Arg Gln Glu 
    290                 295                 300                 


Gln Arg His Ser Leu Pro His Pro Tyr Pro Tyr Pro Ala Pro Ala Tyr 
305                 310                 315                 320 


Thr Ala His Pro Pro Gly His Arg Leu Val Pro Ala Ala Pro Pro Gly 
                325                 330                 335     


Pro Gly Pro Arg Pro Pro Gly Ala Glu Ser His Gly Cys Leu Pro Ala 
            340                 345                 350         


Thr Arg Pro Pro Gly Ser Asp Leu Arg Glu Ser Arg Val Gln Arg Ser 
        355                 360                 365             


Arg Met Asp Ser Ser Val Ser Pro Ala Ala Thr Thr Ala Cys Val Pro 
    370                 375                 380                 


Tyr Ala Pro Ser Arg Pro Pro Gly Leu Pro Gly Thr Thr Thr Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Ser Asn Thr Gly Leu Arg Gly Val Glu Pro Asn 
                405                 410                 415     


Pro Gly Ile Pro Gly Ala Asp His Tyr Gln Thr Pro Ala Leu Glu Val 
            420                 425                 430         


Ser His His Gly Arg Leu Gly Pro Ser Ala His Ser Ser Arg Lys Pro 
        435                 440                 445             


Phe Leu Gly Ala Pro Ala Ala Thr Pro His Leu Ser Leu Pro Pro Gly 
    450                 455                 460                 


Pro Ser Ser Pro Pro Pro Pro Pro Cys Pro Arg Leu Leu Arg Pro Pro 
465                 470                 475                 480 


Pro Pro Pro Ala Trp Leu Lys Gly Pro Ala Cys Arg Ala Ala Arg Glu 
                485                 490                 495     


Asp Gly Glu Ile Leu Glu Glu Leu Phe Phe Gly Thr Glu Gly Pro Pro 
            500                 505                 510         


Arg Pro Ala Pro Pro Pro Leu Pro His Arg Glu Gly Phe Leu Gly Pro 
        515                 520                 525             


Pro Ala Ser Arg Phe Ser Val Gly Thr Gln Asp Ser His Thr Pro Pro 
    530                 535                 540                 


Thr Pro Pro Thr Pro Thr Thr Ser Ser Ser Asn Ser Asn Ser Gly Ser 
545                 550                 555                 560 


His Ser Ser Ser Pro Ala Gly Pro Val Ser Phe Pro Pro Pro Pro Tyr 
                565                 570                 575     


Leu Ala Arg Ser Ile Asp Pro Leu Pro Arg Pro Pro Ser Pro Ala Gln 
            580                 585                 590         


Asn Pro Gln Asp Pro Pro Leu Val Pro Leu Thr Leu Ala Leu Pro Pro 
        595                 600                 605             


Ala Pro Pro Ser Ser Cys His Gln Asn Thr Ser Gly Ser Phe Arg Arg 
    610                 615                 620                 


Pro Glu Ser Pro Arg Pro Arg Val Ser Phe Pro Lys Thr Pro Glu Val 
625                 630                 635                 640 


Gly Pro Gly Pro Pro Pro Gly Pro Leu Ser Lys Ala Pro Gln Pro Val 
                645                 650                 655     


Pro Pro Gly Val Gly Glu Leu Pro Ala Arg Gly Pro Arg Leu Phe Asp 
            660                 665                 670         


Phe Pro Pro Thr Pro Leu Glu Asp Gln Phe Glu Glu Pro Ala Glu Phe 
        675                 680                 685             


Lys Ile Leu Pro Asp Gly Leu Ala Asn Ile Met Lys Met Leu Asp Glu 
    690                 695                 700                 


Ser Ile Arg Lys Glu Glu Glu Gln Gln Gln His Glu Ala Gly Val Ala 
705                 710                 715                 720 


Pro Gln Pro Pro Leu Lys Glu Pro Phe Ala Ser Leu Gln Ser Pro Phe 
                725                 730                 735     


Pro Thr Asp Thr Ala Pro Thr Thr Thr Ala Pro Ala Val Ala Val Thr 
            740                 745                 750         


Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Thr Gln Glu Glu Glu 
        755                 760                 765             


Lys Lys Pro Pro Pro Ala Leu Pro Pro Pro Pro Pro Leu Ala Lys Phe 
    770                 775                 780                 


Pro Pro Pro Ser Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ser Pro 
785                 790                 795                 800 


Ala Ser Leu Leu Lys Ser Leu Ala Ser Val Leu Glu Gly Gln Lys Tyr 
                805                 810                 815     


Cys Tyr Arg Gly Thr Gly Ala Ala Val Ser Thr Arg Pro Gly Pro Leu 
            820                 825                 830         


Pro Thr Thr Gln Tyr Ser Pro Gly Pro Pro Ser Gly Ala Thr Ala Leu 
        835                 840                 845             


Pro Pro Thr Ser Ala Ala Pro Ser Ala Gln Gly Ser Pro Gln Pro Ser 
    850                 855                 860                 


Ala Ser Ser Ser Ser Gln Phe Ser Thr Ser Gly Gly Pro Trp Ala Arg 
865                 870                 875                 880 


Glu Arg Arg Ala Gly Glu Glu Pro Val Pro Gly Pro Met Thr Pro Thr 
                885                 890                 895     


Gln Pro Pro Pro Pro Leu Ser Leu Pro Pro Ala Arg Ser Glu Ser Glu 
            900                 905                 910         


Val Leu Glu Glu Ile Ser Arg Ala Cys Glu Thr Leu Val Glu Arg Val 
        915                 920                 925             


Gly Arg Ser Ala Thr Asp Pro Ala Asp Pro Val Asp Thr Ala Glu Pro 
    930                 935                 940                 


Ala Asp Ser Gly Thr Glu Arg Leu Leu Pro Pro Ala Gln Ala Lys Glu 
945                 950                 955                 960 


Glu Ala Gly Gly Val Ala Ala Val Ser Gly Ser Cys Lys Arg Arg Gln 
                965                 970                 975     


Lys Glu His Gln Lys Glu His Arg Arg His Arg Arg Ala Cys Lys Asp 
            980                 985                 990         


Ser Val Gly Arg Arg Pro Arg Glu  Gly Arg Ala Lys Ala  Lys Ala Lys 
        995                 1000                 1005             


Val Pro  Lys Glu Lys Ser Arg  Arg Val Leu Gly Asn  Leu Asp Leu 
    1010                 1015                 1020             


Gln Ser  Glu Glu Ile Gln Gly  Arg Glu Lys Ser Arg  Pro Asp Leu 
    1025                 1030                 1035             


Gly Gly  Ala Ser Lys Ala Lys  Pro Pro Thr Ala Pro  Ala Pro Pro 
    1040                 1045                 1050             


Ser Ala  Pro Ala Pro Ser Ala  Gln Pro Thr Pro Pro  Ser Ala Ser 
    1055                 1060                 1065             


Val Pro  Gly Lys Lys Ala Arg  Glu Glu Ala Pro Gly  Pro Pro Gly 
    1070                 1075                 1080             


Val Ser  Arg Ala Asp Met Leu  Lys Leu Arg Ser Leu  Ser Glu Gly 
    1085                 1090                 1095             


Pro Pro  Lys Glu Leu Lys Ile  Arg Leu Ile Lys Val  Glu Ser Gly 
    1100                 1105                 1110             


Asp Lys  Glu Thr Phe Ile Ala  Ser Glu Val Glu Glu  Arg Arg Leu 
    1115                 1120                 1125             


Arg Met  Ala Asp Leu Thr Ile  Ser His Cys Ala Ala  Asp Val Val 
    1130                 1135                 1140             


Arg Ala  Ser Arg Asn Ala Lys  Val Lys Gly Lys Phe  Arg Glu Ser 
    1145                 1150                 1155             


Tyr Leu  Ser Pro Ala Gln Ser  Val Lys Pro Lys Ile  Asn Thr Glu 
    1160                 1165                 1170             


Glu Lys  Leu Pro Arg Glu Lys  Leu Asn Pro Pro Thr  Pro Ser Ile 
    1175                 1180                 1185             


Tyr Leu  Glu Ser Lys Arg Asp  Ala Phe Ser Pro Val  Leu Leu Gln 
    1190                 1195                 1200             


Phe Cys  Thr Asp Pro Arg Asn  Pro Ile Thr Val Ile  Arg Gly Leu 
    1205                 1210                 1215             


Ala Gly  Ser Leu Arg Leu Asn  Leu Gly Leu Phe Ser  Thr Lys Thr 
    1220                 1225                 1230             


Leu Val  Glu Ala Ser Gly Glu  His Thr Val Glu Val  Arg Thr Gln 
    1235                 1240                 1245             


Val Gln  Gln Pro Ser Asp Glu  Asn Trp Asp Leu Thr  Gly Thr Arg 
    1250                 1255                 1260             


Gln Ile  Trp Pro Cys Glu Ser  Ser Arg Ser His Thr  Thr Ile Ala 
    1265                 1270                 1275             


Lys Tyr  Ala Gln Tyr Gln Ala  Ser Ser Phe Gln Glu  Ser Leu Gln 
    1280                 1285                 1290             


Glu Glu  Lys Glu Ser Glu Asp  Glu Glu Ser Glu Glu  Pro Asp Ser 
    1295                 1300                 1305             


Thr Thr  Gly Thr Pro Pro Ser  Ser Ala Pro Asp Pro  Lys Asn His 
    1310                 1315                 1320             


His Ile  Ile Lys Phe Gly Thr  Asn Ile Asp Leu Ser  Asp Ala Lys 
    1325                 1330                 1335             


Arg Trp  Lys Pro Gln Leu Gln  Glu Leu Leu Lys Leu  Pro Ala Phe 
    1340                 1345                 1350             


Met Arg  Val Thr Ser Thr Gly  Asn Met Leu Ser His  Val Gly His 
    1355                 1360                 1365             


Thr Ile  Leu Gly Met Asn Thr  Val Gln Leu Tyr Met  Lys Val Pro 
    1370                 1375                 1380             


Gly Ser  Arg Thr Pro Gly His  Gln Glu Asn Asn Asn  Phe Cys Ser 
    1385                 1390                 1395             


Val Asn  Ile Asn Ile Gly Pro  Gly Asp Cys Glu Trp  Phe Ala Val 
    1400                 1405                 1410             


His Glu  His Tyr Trp Glu Thr  Ile Ser Ala Phe Cys  Asp Arg His 
    1415                 1420                 1425             


Gly Val  Asp Tyr Leu Thr Gly  Ser Trp Trp Pro Ile  Leu Asp Asp 
    1430                 1435                 1440             


Leu Tyr  Ala Ser Asn Ile Pro  Val Tyr Arg Phe Val  Gln Arg Pro 
    1445                 1450                 1455             


Gly Asp  Leu Val Trp Ile Asn  Ala Gly Thr Val His  Trp Val Gln 
    1460                 1465                 1470             


Ala Thr  Gly Trp Cys Asn Asn  Ile Ala Trp Asn Val  Gly Pro Leu 
    1475                 1480                 1485             


Thr Ala  Tyr Gln Tyr Gln Leu  Ala Leu Glu Arg Tyr  Glu Trp Asn 
    1490                 1495                 1500             


Glu Val  Lys Asn Val Lys Ser  Ile Val Pro Met Ile  His Val Ser 
    1505                 1510                 1515             


Trp Asn  Val Ala Arg Thr Val  Lys Ile Ser Asp Pro  Asp Leu Phe 
    1520                 1525                 1530             


Lys Met  Ile Lys Phe Cys Leu  Leu Gln Ser Met Lys  His Cys Gln 
    1535                 1540                 1545             


Val Gln  Arg Glu Ser Leu Val  Arg Ala Gly Lys Lys  Ile Ala Tyr 
    1550                 1555                 1560             


Gln Gly  Arg Val Lys Asp Glu  Pro Ala Tyr Tyr Cys  Asn Glu Cys 
    1565                 1570                 1575             


Asp Val  Glu Val Phe Asn Ile  Leu Phe Val Thr Ser  Glu Asn Gly 
    1580                 1585                 1590             


Ser Arg  Asn Thr Tyr Leu Val  His Cys Glu Gly Cys  Ala Arg Arg 
    1595                 1600                 1605             


Arg Ser  Ala Gly Leu Gln Gly  Val Val Val Leu Glu  Gln Tyr Arg 
    1610                 1615                 1620             


Thr Glu  Glu Leu Ala Gln Ala  Tyr Asp Ala Phe Thr  Leu Val Arg 
    1625                 1630                 1635             


Ala Arg  Arg Ala Arg Gly Gln  Arg Arg Arg Ala Leu  Gly Gln Ala 
    1640                 1645                 1650             


Ala Gly  Thr Gly Phe Gly Ser  Pro Ala Ala Pro Phe  Pro Glu Pro 
    1655                 1660                 1665             


Pro Pro  Ala Phe Ser Pro Gln  Ala Pro Ala Ser Thr  Ser Arg 
    1670                 1675                 1680         


<210>  5817
<211>  1356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDR__Homo_sapiens__NP_002244

<400>  5817

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  5818
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDSR__Homo_sapiens__NP_002026

<400>  5818

Met Leu Leu Leu Ala Ala Ala Phe Leu Val Ala Phe Val Leu Leu Leu 
1               5                   10                  15      


Tyr Met Val Ser Pro Leu Ile Ser Pro Lys Pro Leu Ala Leu Pro Gly 
            20                  25                  30          


Ala His Val Val Val Thr Gly Gly Ser Ser Gly Ile Gly Lys Cys Ile 
        35                  40                  45              


Ala Ile Glu Cys Tyr Lys Gln Gly Ala Phe Ile Thr Leu Val Ala Arg 
    50                  55                  60                  


Asn Glu Asp Lys Leu Leu Gln Ala Lys Lys Glu Ile Glu Met His Ser 
65                  70                  75                  80  


Ile Asn Asp Lys Gln Val Val Leu Cys Ile Ser Val Asp Val Ser Gln 
                85                  90                  95      


Asp Tyr Asn Gln Val Glu Asn Val Ile Lys Gln Ala Gln Glu Lys Leu 
            100                 105                 110         


Gly Pro Val Asp Met Leu Val Asn Cys Ala Gly Met Ala Val Ser Gly 
        115                 120                 125             


Lys Phe Glu Asp Leu Glu Val Ser Thr Phe Glu Arg Leu Met Ser Ile 
    130                 135                 140                 


Asn Tyr Leu Gly Ser Val Tyr Pro Ser Arg Ala Val Ile Thr Thr Met 
145                 150                 155                 160 


Lys Glu Arg Arg Val Gly Arg Ile Val Phe Val Ser Ser Gln Ala Gly 
                165                 170                 175     


Gln Leu Gly Leu Phe Gly Phe Thr Ala Tyr Ser Ala Ser Lys Phe Ala 
            180                 185                 190         


Ile Arg Gly Leu Ala Glu Ala Leu Gln Met Glu Val Lys Pro Tyr Asn 
        195                 200                 205             


Val Tyr Ile Thr Val Ala Tyr Pro Pro Asp Thr Asp Thr Pro Gly Phe 
    210                 215                 220                 


Ala Glu Glu Asn Arg Thr Lys Pro Leu Glu Thr Arg Leu Ile Ser Glu 
225                 230                 235                 240 


Thr Thr Ser Val Cys Lys Pro Glu Gln Val Ala Lys Gln Ile Val Lys 
                245                 250                 255     


Asp Ala Ile Gln Gly Asn Phe Asn Ser Ser Leu Gly Ser Asp Gly Tyr 
            260                 265                 270         


Met Leu Ser Ala Leu Thr Cys Gly Met Ala Pro Val Thr Ser Ile Thr 
        275                 280                 285             


Glu Gly Leu Gln Gln Val Val Thr Met Gly Leu Phe Arg Thr Ile Ala 
    290                 295                 300                 


Leu Phe Tyr Leu Gly Ser Phe Asp Ser Ile Val Arg Arg Cys Met Met 
305                 310                 315                 320 


Gln Arg Glu Lys Ser Glu Asn Ala Asp Lys Thr Ala 
                325                 330         


<210>  5819
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KEAP1__Homo_sapiens__NP_036421

<400>  5819

Met Gln Pro Asp Pro Arg Pro Ser Gly Ala Gly Ala Cys Cys Arg Phe 
1               5                   10                  15      


Leu Pro Leu Gln Ser Gln Cys Pro Glu Gly Ala Gly Asp Ala Val Met 
            20                  25                  30          


Tyr Ala Ser Thr Glu Cys Lys Ala Glu Val Thr Pro Ser Gln His Gly 
        35                  40                  45              


Asn Arg Thr Phe Ser Tyr Thr Leu Glu Asp His Thr Lys Gln Ala Phe 
    50                  55                  60                  


Gly Ile Met Asn Glu Leu Arg Leu Ser Gln Gln Leu Cys Asp Val Thr 
65                  70                  75                  80  


Leu Gln Val Lys Tyr Gln Asp Ala Pro Ala Ala Gln Phe Met Ala His 
                85                  90                  95      


Lys Val Val Leu Ala Ser Ser Ser Pro Val Phe Lys Ala Met Phe Thr 
            100                 105                 110         


Asn Gly Leu Arg Glu Gln Gly Met Glu Val Val Ser Ile Glu Gly Ile 
        115                 120                 125             


His Pro Lys Val Met Glu Arg Leu Ile Glu Phe Ala Tyr Thr Ala Ser 
    130                 135                 140                 


Ile Ser Met Gly Glu Lys Cys Val Leu His Val Met Asn Gly Ala Val 
145                 150                 155                 160 


Met Tyr Gln Ile Asp Ser Val Val Arg Ala Cys Ser Asp Phe Leu Val 
                165                 170                 175     


Gln Gln Leu Asp Pro Ser Asn Ala Ile Gly Ile Ala Asn Phe Ala Glu 
            180                 185                 190         


Gln Ile Gly Cys Val Glu Leu His Gln Arg Ala Arg Glu Tyr Ile Tyr 
        195                 200                 205             


Met His Phe Gly Glu Val Ala Lys Gln Glu Glu Phe Phe Asn Leu Ser 
    210                 215                 220                 


His Cys Gln Leu Val Thr Leu Ile Ser Arg Asp Asp Leu Asn Val Arg 
225                 230                 235                 240 


Cys Glu Ser Glu Val Phe His Ala Cys Ile Asn Trp Val Lys Tyr Asp 
                245                 250                 255     


Cys Glu Gln Arg Arg Phe Tyr Val Gln Ala Leu Leu Arg Ala Val Arg 
            260                 265                 270         


Cys His Ser Leu Thr Pro Asn Phe Leu Gln Met Gln Leu Gln Lys Cys 
        275                 280                 285             


Glu Ile Leu Gln Ser Asp Ser Arg Cys Lys Asp Tyr Leu Val Lys Ile 
    290                 295                 300                 


Phe Glu Glu Leu Thr Leu His Lys Pro Thr Gln Val Met Pro Cys Arg 
305                 310                 315                 320 


Ala Pro Lys Val Gly Arg Leu Ile Tyr Thr Ala Gly Gly Tyr Phe Arg 
                325                 330                 335     


Gln Ser Leu Ser Tyr Leu Glu Ala Tyr Asn Pro Ser Asp Gly Thr Trp 
            340                 345                 350         


Leu Arg Leu Ala Asp Leu Gln Val Pro Arg Ser Gly Leu Ala Gly Cys 
        355                 360                 365             


Val Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Arg Asn Asn Ser Pro 
    370                 375                 380                 


Asp Gly Asn Thr Asp Ser Ser Ala Leu Asp Cys Tyr Asn Pro Met Thr 
385                 390                 395                 400 


Asn Gln Trp Ser Pro Cys Ala Pro Met Ser Val Pro Arg Asn Arg Ile 
                405                 410                 415     


Gly Val Gly Val Ile Asp Gly His Ile Tyr Ala Val Gly Gly Ser His 
            420                 425                 430         


Gly Cys Ile His His Asn Ser Val Glu Arg Tyr Glu Pro Glu Arg Asp 
        435                 440                 445             


Glu Trp His Leu Val Ala Pro Met Leu Thr Arg Arg Ile Gly Val Gly 
    450                 455                 460                 


Val Ala Val Leu Asn Arg Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly 
465                 470                 475                 480 


Thr Asn Arg Leu Asn Ser Ala Glu Cys Tyr Tyr Pro Glu Arg Asn Glu 
                485                 490                 495     


Trp Arg Met Ile Thr Ala Met Asn Thr Ile Arg Ser Gly Ala Gly Val 
            500                 505                 510         


Cys Val Leu His Asn Cys Ile Tyr Ala Ala Gly Gly Tyr Asp Gly Gln 
        515                 520                 525             


Asp Gln Leu Asn Ser Val Glu Arg Tyr Asp Val Glu Thr Glu Thr Trp 
    530                 535                 540                 


Thr Phe Val Ala Pro Met Lys His Arg Arg Ser Ala Leu Gly Ile Thr 
545                 550                 555                 560 


Val His Gln Gly Arg Ile Tyr Val Leu Gly Gly Tyr Asp Gly His Thr 
                565                 570                 575     


Phe Leu Asp Ser Val Glu Cys Tyr Asp Pro Asp Thr Asp Thr Trp Ser 
            580                 585                 590         


Glu Val Thr Arg Met Thr Ser Gly Arg Ser Gly Val Gly Val Ala Val 
        595                 600                 605             


Thr Met Glu Pro Cys Arg Lys Gln Ile Asp Gln Gln Asn Cys Thr Cys 
    610                 615                 620                 


<210>  5820
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KEL__Homo_sapiens__NP_000411

<400>  5820

Met Glu Gly Gly Asp Gln Ser Glu Glu Glu Pro Arg Glu Arg Ser Gln 
1               5                   10                  15      


Ala Gly Gly Met Gly Thr Leu Trp Ser Gln Glu Ser Thr Pro Glu Glu 
            20                  25                  30          


Arg Leu Pro Val Glu Gly Ser Arg Pro Trp Ala Val Ala Arg Arg Val 
        35                  40                  45              


Leu Thr Ala Ile Leu Ile Leu Gly Leu Leu Leu Cys Phe Ser Val Leu 
    50                  55                  60                  


Leu Phe Tyr Asn Phe Gln Asn Cys Gly Pro Arg Pro Cys Glu Thr Ser 
65                  70                  75                  80  


Val Cys Leu Asp Leu Arg Asp His Tyr Leu Ala Ser Gly Asn Thr Ser 
                85                  90                  95      


Val Ala Pro Cys Thr Asp Phe Phe Ser Phe Ala Cys Gly Arg Ala Lys 
            100                 105                 110         


Glu Thr Asn Asn Ser Phe Gln Glu Leu Ala Thr Lys Asn Lys Asn Arg 
        115                 120                 125             


Leu Arg Arg Ile Leu Glu Val Gln Asn Ser Trp His Pro Gly Ser Gly 
    130                 135                 140                 


Glu Glu Lys Ala Phe Gln Phe Tyr Asn Ser Cys Met Asp Thr Leu Ala 
145                 150                 155                 160 


Ile Glu Ala Ala Gly Thr Gly Pro Leu Arg Gln Val Ile Glu Glu Leu 
                165                 170                 175     


Gly Gly Trp Arg Ile Ser Gly Lys Trp Thr Ser Leu Asn Phe Asn Arg 
            180                 185                 190         


Thr Leu Arg Leu Leu Met Ser Gln Tyr Gly His Phe Pro Phe Phe Arg 
        195                 200                 205             


Ala Tyr Leu Gly Pro His Pro Ala Ser Pro His Thr Pro Val Ile Gln 
    210                 215                 220                 


Ile Asp Gln Pro Glu Phe Asp Val Pro Leu Lys Gln Asp Gln Glu Gln 
225                 230                 235                 240 


Lys Ile Tyr Ala Gln Ile Phe Arg Glu Tyr Leu Thr Tyr Leu Asn Gln 
                245                 250                 255     


Leu Gly Thr Leu Leu Gly Gly Asp Pro Ser Lys Val Gln Glu His Ser 
            260                 265                 270         


Ser Leu Ser Ile Ser Ile Thr Ser Arg Leu Phe Gln Phe Leu Arg Pro 
        275                 280                 285             


Leu Glu Gln Arg Arg Ala Gln Gly Lys Leu Phe Gln Met Val Thr Ile 
    290                 295                 300                 


Asp Gln Leu Lys Glu Met Ala Pro Ala Ile Asp Trp Leu Ser Cys Leu 
305                 310                 315                 320 


Gln Ala Thr Phe Thr Pro Met Ser Leu Ser Pro Ser Gln Ser Leu Val 
                325                 330                 335     


Val His Asp Val Glu Tyr Leu Lys Asn Met Ser Gln Leu Val Glu Glu 
            340                 345                 350         


Met Leu Leu Lys Gln Arg Asp Phe Leu Gln Ser His Met Ile Leu Gly 
        355                 360                 365             


Leu Val Val Thr Leu Ser Pro Ala Leu Asp Ser Gln Phe Gln Glu Ala 
    370                 375                 380                 


Arg Arg Lys Leu Ser Gln Lys Leu Arg Glu Leu Thr Glu Gln Pro Pro 
385                 390                 395                 400 


Met Pro Ala Arg Pro Arg Trp Met Lys Cys Val Glu Glu Thr Gly Thr 
                405                 410                 415     


Phe Phe Glu Pro Thr Leu Ala Ala Leu Phe Val Arg Glu Ala Phe Gly 
            420                 425                 430         


Pro Ser Thr Arg Ser Ala Ala Met Lys Leu Phe Thr Ala Ile Arg Asp 
        435                 440                 445             


Ala Leu Ile Thr Arg Leu Arg Asn Leu Pro Trp Met Asn Glu Glu Thr 
    450                 455                 460                 


Gln Asn Met Ala Gln Asp Lys Val Ala Gln Leu Gln Val Glu Met Gly 
465                 470                 475                 480 


Ala Ser Glu Trp Ala Leu Lys Pro Glu Leu Ala Arg Gln Glu Tyr Asn 
                485                 490                 495     


Asp Ile Gln Leu Gly Ser Ser Phe Leu Gln Ser Val Leu Ser Cys Val 
            500                 505                 510         


Arg Ser Leu Arg Ala Arg Ile Val Gln Ser Phe Leu Gln Pro His Pro 
        515                 520                 525             


Gln His Arg Trp Lys Val Ser Pro Trp Asp Val Asn Ala Tyr Tyr Ser 
    530                 535                 540                 


Val Ser Asp His Val Val Val Phe Pro Ala Gly Leu Leu Gln Pro Pro 
545                 550                 555                 560 


Phe Phe His Pro Gly Tyr Pro Arg Ala Val Asn Phe Gly Ala Ala Gly 
                565                 570                 575     


Ser Ile Met Ala His Glu Leu Leu His Ile Phe Tyr Gln Leu Leu Leu 
            580                 585                 590         


Pro Gly Gly Cys Leu Ala Cys Asp Asn His Ala Leu Gln Glu Ala His 
        595                 600                 605             


Leu Cys Leu Lys Arg His Tyr Ala Ala Phe Pro Leu Pro Ser Arg Thr 
    610                 615                 620                 


Ser Phe Asn Asp Ser Leu Thr Phe Leu Glu Asn Ala Ala Asp Val Gly 
625                 630                 635                 640 


Gly Leu Ala Ile Ala Leu Gln Ala Tyr Ser Lys Arg Leu Leu Arg His 
                645                 650                 655     


His Gly Glu Thr Val Leu Pro Ser Leu Asp Leu Ser Pro Gln Gln Ile 
            660                 665                 670         


Phe Phe Arg Ser Tyr Ala Gln Val Met Cys Arg Lys Pro Ser Pro Gln 
        675                 680                 685             


Asp Ser His Asp Thr His Ser Pro Pro His Leu Arg Val His Gly Pro 
    690                 695                 700                 


Leu Ser Ser Thr Pro Ala Phe Ala Arg Tyr Phe Arg Cys Ala Arg Gly 
705                 710                 715                 720 


Ala Leu Leu Asn Pro Ser Ser Arg Cys Gln Leu Trp 
                725                 730         


<210>  5821
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KERA__Homo_sapiens__XP_011536083

<400>  5821

Met Ala Gly Thr Ile Cys Phe Ile Met Trp Val Leu Phe Ile Thr Asp 
1               5                   10                  15      


Thr Val Trp Ser Arg Ser Val Arg Gln Val Tyr Glu Val His Asp Ser 
            20                  25                  30          


Asp Asp Trp Thr Ile His Asp Phe Glu Cys Pro Met Glu Cys Phe Cys 
        35                  40                  45              


Pro Pro Ser Phe Pro Thr Ala Leu Tyr Cys Glu Asn Arg Gly Leu Lys 
    50                  55                  60                  


Glu Ile Pro Ala Ile Pro Ser Arg Ile Trp Tyr Leu Tyr Leu Gln Asn 
65                  70                  75                  80  


Asn Leu Ile Glu Thr Ile Pro Glu Lys Pro Phe Glu Asn Ala Thr Gln 
                85                  90                  95      


Leu Arg Trp Ile Asn Leu Asn Lys Asn Lys Ile Thr Asn Tyr Gly Ile 
            100                 105                 110         


Glu Lys Gly Ala Leu Ser Gln Leu Lys Lys Leu Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Asp Asn Glu Leu Glu Glu Val Pro Ser Pro Leu Pro Arg Ser Leu 
    130                 135                 140                 


Glu Gln Leu Gln Leu Ala Arg Asn Lys Val Ser Arg Ile Pro Gln Gly 
145                 150                 155                 160 


Thr Phe Ser Asn Leu Glu Asn Leu Thr Leu Leu Asp Leu Gln Asn Asn 
                165                 170                 175     


Lys Leu Val Asp Asn Ala Phe Gln Arg Asp Thr Phe Lys Gly Leu Lys 
            180                 185                 190         


Asn Leu Met Gln Leu Asn Met Ala Lys Asn Ala Leu Arg Asn Met Pro 
        195                 200                 205             


Pro Arg Leu Pro Ala Asn Thr Met Gln Leu Phe Leu Asp Asn Asn Ser 
    210                 215                 220                 


Ile Glu Gly Ile Pro Glu Asn Tyr Phe Asn Val Ile Pro Lys Val Ala 
225                 230                 235                 240 


Phe Leu Arg Leu Asn His Asn Lys Leu Ser Asp Glu Gly Leu Pro Ser 
                245                 250                 255     


Arg Gly Phe Asp Val Ser Ser Ile Leu Asp Leu Gln Leu Ser His Asn 
            260                 265                 270         


Gln Leu Thr Lys Val Pro Arg Ile Ser Ala His Leu Gln His Leu His 
        275                 280                 285             


Leu Asp His Asn Lys Ile Lys Ser Val Asn Val Ser Val Ile Cys Pro 
    290                 295                 300                 


Ser Pro Ser Met Leu Pro Ala Glu Arg Asp Ser Phe Ser Tyr Gly Pro 
305                 310                 315                 320 


His Leu Arg Tyr Leu Arg Leu Asp Gly Asn Glu Ile Lys Pro Pro Ile 
                325                 330                 335     


Pro Met Ala Leu Met Thr Cys Phe Arg Leu Leu Gln Ala Val Ile Ile 
            340                 345                 350         


<210>  5822
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KHDC3L__Homo_sapiens__NP_001017361

<400>  5822

Met Asp Ala Pro Arg Arg Phe Pro Thr Leu Val Gln Leu Met Gln Pro 
1               5                   10                  15      


Lys Ala Met Pro Val Glu Val Leu Gly His Leu Pro Lys Arg Phe Ser 
            20                  25                  30          


Trp Phe His Ser Glu Phe Leu Lys Asn Pro Lys Val Val Arg Leu Glu 
        35                  40                  45              


Val Trp Leu Val Glu Lys Ile Phe Gly Arg Gly Gly Glu Arg Ile Pro 
    50                  55                  60                  


His Val Gln Gly Met Ser Gln Ile Leu Ile His Val Asn Arg Leu Asp 
65                  70                  75                  80  


Pro Asn Gly Glu Ala Glu Ile Leu Val Phe Gly Arg Pro Ser Tyr Gln 
                85                  90                  95      


Glu Asp Thr Ile Lys Met Ile Met Asn Leu Ala Asp Tyr His Arg Gln 
            100                 105                 110         


Leu Gln Ala Lys Gly Ser Gly Lys Ala Leu Ala Gln Asp Val Ala Thr 
        115                 120                 125             


Gln Lys Ala Glu Thr Gln Arg Ser Ser Ile Glu Val Arg Glu Ala Gly 
    130                 135                 140                 


Thr Gln Arg Ser Val Glu Val Arg Glu Ala Gly Thr Gln Arg Ser Val 
145                 150                 155                 160 


Glu Val Gln Glu Val Gly Thr Gln Gly Ser Pro Val Glu Val Gln Glu 
                165                 170                 175     


Ala Gly Thr Gln Gln Ser Leu Gln Ala Ala Asn Lys Ser Gly Thr Gln 
            180                 185                 190         


Arg Ser Pro Glu Ala Ala Ser Lys Ala Val Thr Gln Arg Phe Arg Glu 
        195                 200                 205             


Asp Ala Arg Asp Pro Val Thr Arg Leu 
    210                 215         


<210>  5823
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KHDRBS2__Homo_sapiens__NP_689901

<400>  5823

Met Glu Glu Glu Lys Tyr Leu Pro Glu Leu Met Ala Glu Lys Asp Ser 
1               5                   10                  15      


Leu Asp Pro Ser Phe Val His Ala Ser Arg Leu Leu Ala Glu Glu Ile 
            20                  25                  30          


Glu Lys Phe Gln Gly Ser Asp Gly Lys Lys Glu Asp Glu Glu Lys Lys 
        35                  40                  45              


Tyr Leu Asp Val Ile Ser Asn Lys Asn Ile Lys Leu Ser Glu Arg Val 
    50                  55                  60                  


Leu Ile Pro Val Lys Gln Tyr Pro Lys Phe Asn Phe Val Gly Lys Leu 
65                  70                  75                  80  


Leu Gly Pro Arg Gly Asn Ser Leu Lys Arg Leu Gln Glu Glu Thr Gly 
                85                  90                  95      


Ala Lys Met Ser Ile Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys 
            100                 105                 110         


Glu Glu Glu Leu Arg Lys Ser Gly Glu Ala Lys Tyr Ala His Leu Ser 
        115                 120                 125             


Asp Glu Leu His Val Leu Ile Glu Val Phe Ala Pro Pro Gly Glu Ala 
    130                 135                 140                 


Tyr Ser Arg Met Ser His Ala Leu Glu Glu Ile Lys Lys Phe Leu Val 
145                 150                 155                 160 


Pro Asp Tyr Asn Asp Glu Ile Arg Gln Glu Gln Leu Arg Glu Leu Ser 
                165                 170                 175     


Tyr Leu Asn Gly Ser Glu Asp Ser Gly Arg Gly Arg Gly Ile Arg Gly 
            180                 185                 190         


Arg Gly Ile Arg Ile Ala Pro Thr Ala Pro Ser Arg Gly Arg Gly Gly 
        195                 200                 205             


Ala Ile Pro Pro Pro Pro Pro Pro Gly Arg Gly Val Leu Thr Pro Arg 
    210                 215                 220                 


Gly Ser Thr Val Thr Arg Gly Ala Leu Pro Val Pro Pro Val Ala Arg 
225                 230                 235                 240 


Gly Val Pro Thr Pro Arg Ala Arg Gly Ala Pro Thr Val Pro Gly Tyr 
                245                 250                 255     


Arg Ala Pro Pro Pro Pro Ala His Glu Ala Tyr Glu Glu Tyr Gly Tyr 
            260                 265                 270         


Asp Asp Gly Tyr Gly Gly Glu Tyr Asp Asp Gln Thr Tyr Glu Thr Tyr 
        275                 280                 285             


Asp Asn Ser Tyr Ala Thr Gln Thr Gln Ser Val Pro Glu Tyr Tyr Asp 
    290                 295                 300                 


Tyr Gly His Gly Val Ser Glu Asp Ala Tyr Asp Ser Tyr Ala Pro Glu 
305                 310                 315                 320 


Glu Trp Ala Thr Thr Arg Ser Ser Leu Lys Ala Pro Pro Gln Arg Ser 
                325                 330                 335     


Ala Arg Gly Gly Tyr Arg Glu His Pro Tyr Gly Arg Tyr 
            340                 345                 


<210>  5824
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KHDRBS3__Homo_sapiens__NP_006549

<400>  5824

Met Glu Glu Lys Tyr Leu Pro Glu Leu Met Ala Glu Lys Asp Ser Leu 
1               5                   10                  15      


Asp Pro Ser Phe Thr His Ala Leu Arg Leu Val Asn Gln Glu Ile Glu 
            20                  25                  30          


Lys Phe Gln Lys Gly Glu Gly Lys Asp Glu Glu Lys Tyr Ile Asp Val 
        35                  40                  45              


Val Ile Asn Lys Asn Met Lys Leu Gly Gln Lys Val Leu Ile Pro Val 
    50                  55                  60                  


Lys Gln Phe Pro Lys Phe Asn Phe Val Gly Lys Leu Leu Gly Pro Arg 
65                  70                  75                  80  


Gly Asn Ser Leu Lys Arg Leu Gln Glu Glu Thr Leu Thr Lys Met Ser 
                85                  90                  95      


Ile Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys Glu Glu Glu Leu 
            100                 105                 110         


Arg Lys Ser Gly Glu Ala Lys Tyr Phe His Leu Asn Asp Asp Leu His 
        115                 120                 125             


Val Leu Ile Glu Val Phe Ala Pro Pro Ala Glu Ala Tyr Ala Arg Met 
    130                 135                 140                 


Gly His Ala Leu Glu Glu Ile Lys Lys Phe Leu Ile Pro Asp Tyr Asn 
145                 150                 155                 160 


Asp Glu Ile Arg Gln Ala Gln Leu Gln Glu Leu Thr Tyr Leu Asn Gly 
                165                 170                 175     


Gly Ser Glu Asn Ala Asp Val Pro Val Val Arg Gly Lys Pro Thr Leu 
            180                 185                 190         


Arg Thr Arg Gly Val Pro Ala Pro Ala Ile Thr Arg Gly Arg Gly Gly 
        195                 200                 205             


Val Thr Ala Arg Pro Val Gly Val Val Val Pro Arg Gly Thr Pro Thr 
    210                 215                 220                 


Pro Arg Gly Val Leu Ser Thr Arg Gly Pro Val Ser Arg Gly Arg Gly 
225                 230                 235                 240 


Leu Leu Thr Pro Arg Ala Arg Gly Val Pro Pro Thr Gly Tyr Arg Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Thr Gln Glu Thr Tyr Gly Glu Tyr Asp Tyr Asp 
            260                 265                 270         


Asp Gly Tyr Gly Thr Ala Tyr Asp Glu Gln Ser Tyr Asp Ser Tyr Asp 
        275                 280                 285             


Asn Ser Tyr Ser Thr Pro Ala Gln Ser Gly Ala Asp Tyr Tyr Asp Tyr 
    290                 295                 300                 


Gly His Gly Leu Ser Glu Glu Thr Tyr Asp Ser Tyr Gly Gln Glu Glu 
305                 310                 315                 320 


Trp Thr Asn Ser Arg His Lys Ala Pro Ser Ala Arg Thr Ala Lys Gly 
                325                 330                 335     


Val Tyr Arg Asp Gln Pro Tyr Gly Arg Tyr 
            340                 345     


<210>  5825
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KHK__Homo_sapiens__NP_000212

<400>  5825

Met Glu Glu Lys Gln Ile Leu Cys Val Gly Leu Val Val Leu Asp Val 
1               5                   10                  15      


Ile Ser Leu Val Asp Lys Tyr Pro Lys Glu Asp Ser Glu Ile Arg Cys 
            20                  25                  30          


Leu Ser Gln Arg Trp Gln Arg Gly Gly Asn Ala Ser Asn Ser Cys Thr 
        35                  40                  45              


Val Leu Ser Leu Leu Gly Ala Pro Cys Ala Phe Met Gly Ser Met Ala 
    50                  55                  60                  


Pro Gly His Val Ala Asp Phe Val Leu Asp Asp Leu Arg Arg Tyr Ser 
65                  70                  75                  80  


Val Asp Leu Arg Tyr Thr Val Phe Gln Thr Thr Gly Ser Val Pro Ile 
                85                  90                  95      


Ala Thr Val Ile Ile Asn Glu Ala Ser Gly Ser Arg Thr Ile Leu Tyr 
            100                 105                 110         


Tyr Asp Arg Ser Leu Pro Asp Val Ser Ala Thr Asp Phe Glu Lys Val 
        115                 120                 125             


Asp Leu Thr Gln Phe Lys Trp Ile His Ile Glu Gly Arg Asn Ala Ser 
    130                 135                 140                 


Glu Gln Val Lys Met Leu Gln Arg Ile Asp Ala His Asn Thr Arg Gln 
145                 150                 155                 160 


Pro Pro Glu Gln Lys Ile Arg Val Ser Val Glu Val Glu Lys Pro Arg 
                165                 170                 175     


Glu Glu Leu Phe Gln Leu Phe Gly Tyr Gly Asp Val Val Phe Val Ser 
            180                 185                 190         


Lys Asp Val Ala Lys His Leu Gly Phe Gln Ser Ala Glu Glu Ala Leu 
        195                 200                 205             


Arg Gly Leu Tyr Gly Arg Val Arg Lys Gly Ala Val Leu Val Cys Ala 
    210                 215                 220                 


Trp Ala Glu Glu Gly Ala Asp Ala Leu Gly Pro Asp Gly Lys Leu Leu 
225                 230                 235                 240 


His Ser Asp Ala Phe Pro Pro Pro Arg Val Val Asp Thr Leu Gly Ala 
                245                 250                 255     


Gly Asp Thr Phe Asn Ala Ser Val Ile Phe Ser Leu Ser Gln Gly Arg 
            260                 265                 270         


Ser Val Gln Glu Ala Leu Arg Phe Gly Cys Gln Val Ala Gly Lys Lys 
        275                 280                 285             


Cys Gly Leu Gln Gly Phe Asp Gly Ile Val 
    290                 295             


<210>  5826
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KHSRP__Homo_sapiens__NP_003676

<400>  5826

Met Ser Asp Tyr Ser Thr Gly Gly Pro Pro Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Pro Pro Pro 
            20                  25                  30          


Gly Pro Pro Gly Ala Gly Asp Arg Gly Gly Gly Gly Pro Gly Gly Gly 
        35                  40                  45              


Gly Pro Gly Gly Gly Ser Ala Gly Gly Pro Ser Gln Pro Pro Gly Gly 
    50                  55                  60                  


Gly Gly Pro Gly Ile Arg Lys Asp Ala Phe Ala Asp Ala Val Gln Arg 
65                  70                  75                  80  


Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp Ala Ala Thr Thr Val 
                85                  90                  95      


Asn Asn Ser Thr Pro Asp Phe Gly Phe Gly Gly Gln Lys Arg Gln Leu 
            100                 105                 110         


Glu Asp Gly Asp Gln Pro Glu Ser Lys Lys Leu Ala Ser Gln Gly Asp 
        115                 120                 125             


Ser Ile Ser Ser Gln Leu Gly Pro Ile His Pro Pro Pro Arg Thr Ser 
    130                 135                 140                 


Met Thr Glu Glu Tyr Arg Val Pro Asp Gly Met Val Gly Leu Ile Ile 
145                 150                 155                 160 


Gly Arg Gly Gly Glu Gln Ile Asn Lys Ile Gln Gln Asp Ser Gly Cys 
                165                 170                 175     


Lys Val Gln Ile Ser Pro Asp Ser Gly Gly Leu Pro Glu Arg Ser Val 
            180                 185                 190         


Ser Leu Thr Gly Ala Pro Glu Ser Val Gln Lys Ala Lys Met Met Leu 
        195                 200                 205             


Asp Asp Ile Val Ser Arg Gly Arg Gly Gly Pro Pro Gly Gln Phe His 
    210                 215                 220                 


Asp Asn Ala Asn Gly Gly Gln Asn Gly Thr Val Gln Glu Ile Met Ile 
225                 230                 235                 240 


Pro Ala Gly Lys Ala Gly Leu Val Ile Gly Lys Gly Gly Glu Thr Ile 
                245                 250                 255     


Lys Gln Leu Gln Glu Arg Ala Gly Val Lys Met Ile Leu Ile Gln Asp 
            260                 265                 270         


Gly Ser Gln Asn Thr Asn Val Asp Lys Pro Leu Arg Ile Ile Gly Asp 
        275                 280                 285             


Pro Tyr Lys Val Gln Gln Ala Cys Glu Met Val Met Asp Ile Leu Arg 
    290                 295                 300                 


Glu Arg Asp Gln Gly Gly Phe Gly Asp Arg Asn Glu Tyr Gly Ser Arg 
305                 310                 315                 320 


Ile Gly Gly Gly Ile Asp Val Pro Val Pro Arg His Ser Val Gly Val 
                325                 330                 335     


Val Ile Gly Arg Ser Gly Glu Met Ile Lys Lys Ile Gln Asn Asp Ala 
            340                 345                 350         


Gly Val Arg Ile Gln Phe Lys Gln Asp Asp Gly Thr Gly Pro Glu Lys 
        355                 360                 365             


Ile Ala His Ile Met Gly Pro Pro Asp Arg Cys Glu His Ala Ala Arg 
    370                 375                 380                 


Ile Ile Asn Asp Leu Leu Gln Ser Leu Arg Ser Gly Pro Pro Gly Pro 
385                 390                 395                 400 


Pro Gly Gly Pro Gly Met Pro Pro Gly Gly Arg Gly Arg Gly Arg Gly 
                405                 410                 415     


Gln Gly Asn Trp Gly Pro Pro Gly Gly Glu Met Thr Phe Ser Ile Pro 
            420                 425                 430         


Thr His Lys Cys Gly Leu Val Ile Gly Arg Gly Gly Glu Asn Val Lys 
        435                 440                 445             


Ala Ile Asn Gln Gln Thr Gly Ala Phe Val Glu Ile Ser Arg Gln Leu 
    450                 455                 460                 


Pro Pro Asn Gly Asp Pro Asn Phe Lys Leu Phe Ile Ile Arg Gly Ser 
465                 470                 475                 480 


Pro Gln Gln Ile Asp His Ala Lys Gln Leu Ile Glu Glu Lys Ile Glu 
                485                 490                 495     


Gly Pro Leu Cys Pro Val Gly Pro Gly Pro Gly Gly Pro Gly Pro Ala 
            500                 505                 510         


Gly Pro Met Gly Pro Phe Asn Pro Gly Pro Phe Asn Gln Gly Pro Pro 
        515                 520                 525             


Gly Ala Pro Pro His Ala Gly Gly Pro Pro Pro His Gln Tyr Pro Pro 
    530                 535                 540                 


Gln Gly Trp Gly Asn Thr Tyr Pro Gln Trp Gln Pro Pro Ala Pro His 
545                 550                 555                 560 


Asp Pro Ser Lys Ala Ala Ala Ala Ala Ala Asp Pro Asn Ala Ala Trp 
                565                 570                 575     


Ala Ala Tyr Tyr Ser His Tyr Tyr Gln Gln Pro Pro Gly Pro Val Pro 
            580                 585                 590         


Gly Pro Ala Pro Ala Pro Ala Ala Pro Pro Ala Gln Gly Glu Pro Pro 
        595                 600                 605             


Gln Pro Pro Pro Thr Gly Gln Ser Asp Tyr Thr Lys Ala Trp Glu Glu 
    610                 615                 620                 


Tyr Tyr Lys Lys Ile Gly Gln Gln Pro Gln Gln Pro Gly Ala Pro Pro 
625                 630                 635                 640 


Gln Gln Asp Tyr Thr Lys Ala Trp Glu Glu Tyr Tyr Lys Lys Gln Ala 
                645                 650                 655     


Gln Val Ala Thr Gly Gly Gly Pro Gly Ala Pro Pro Gly Ser Gln Pro 
            660                 665                 670         


Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Ala Ala Tyr 
        675                 680                 685             


Tyr Gly Gln Thr Pro Gly Pro Gly Gly Pro Gln Pro Pro Pro Thr Gln 
    690                 695                 700                 


Gln Gly Gln Gln Gln Ala Gln 
705                 710     


<210>  5827
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0020__Homo_sapiens__NP_055693

<400>  5827

Met Glu Val Lys Gly Lys Lys Gln Phe Thr Gly Lys Ser Thr Lys Thr 
1               5                   10                  15      


Ala Gln Glu Lys Asn Arg Phe His Lys Asn Ser Asp Ser Gly Ser Ser 
            20                  25                  30          


Lys Thr Phe Pro Thr Arg Lys Val Ala Lys Glu Gly Gly Pro Lys Val 
        35                  40                  45              


Thr Ser Arg Asn Phe Glu Lys Ser Ile Thr Lys Leu Gly Lys Lys Gly 
    50                  55                  60                  


Val Lys Gln Phe Lys Asn Lys Gln Gln Gly Asp Lys Ser Pro Lys Asn 
65                  70                  75                  80  


Lys Phe Gln Pro Ala Asn Lys Phe Asn Lys Lys Arg Lys Phe Gln Pro 
                85                  90                  95      


Asp Gly Arg Ser Asp Glu Ser Ala Ala Lys Lys Pro Lys Trp Asp Asp 
            100                 105                 110         


Phe Lys Lys Lys Lys Lys Glu Leu Lys Gln Ser Arg Gln Leu Ser Asp 
        115                 120                 125             


Lys Thr Asn Tyr Asp Ile Val Val Arg Ala Lys Gln Met Trp Glu Ile 
    130                 135                 140                 


Leu Arg Arg Lys Asp Cys Asp Lys Glu Lys Arg Val Lys Leu Met Ser 
145                 150                 155                 160 


Asp Leu Gln Lys Leu Ile Gln Gly Lys Ile Lys Thr Ile Ala Phe Ala 
                165                 170                 175     


His Asp Ser Thr Arg Val Ile Gln Cys Tyr Ile Gln Tyr Gly Asn Glu 
            180                 185                 190         


Glu Gln Arg Lys Gln Ala Phe Glu Glu Leu Arg Asp Asp Leu Val Glu 
        195                 200                 205             


Leu Ser Lys Ala Lys Tyr Ser Arg Asn Ile Val Lys Lys Phe Leu Met 
    210                 215                 220                 


Tyr Gly Ser Lys Pro Gln Ile Ala Glu Ile Ile Arg Ser Phe Lys Gly 
225                 230                 235                 240 


His Val Arg Lys Met Leu Arg His Ala Glu Ala Ser Ala Ile Val Glu 
                245                 250                 255     


Tyr Ala Tyr Asn Asp Lys Ala Ile Leu Glu Gln Arg Asn Met Leu Thr 
            260                 265                 270         


Glu Glu Leu Tyr Gly Asn Thr Phe Gln Leu Tyr Lys Ser Ala Asp His 
        275                 280                 285             


Arg Thr Leu Asp Lys Val Leu Glu Val Gln Pro Glu Lys Leu Glu Leu 
    290                 295                 300                 


Ile Met Asp Glu Met Lys Gln Ile Leu Thr Pro Met Ala Gln Lys Glu 
305                 310                 315                 320 


Ala Val Ile Lys His Ser Leu Val His Lys Val Phe Leu Asp Phe Phe 
                325                 330                 335     


Thr Tyr Ala Pro Pro Lys Leu Arg Ser Glu Met Ile Glu Ala Ile Arg 
            340                 345                 350         


Glu Ala Val Val Tyr Leu Ala His Thr His Asp Gly Ala Arg Val Ala 
        355                 360                 365             


Met His Cys Leu Trp His Gly Thr Pro Lys Asp Arg Lys Val Ile Val 
    370                 375                 380                 


Lys Thr Met Lys Thr Tyr Val Glu Lys Val Ala Asn Gly Gln Tyr Ser 
385                 390                 395                 400 


His Leu Val Leu Leu Ala Ala Phe Asp Cys Ile Asp Asp Thr Lys Leu 
                405                 410                 415     


Val Lys Gln Ile Ile Ile Ser Glu Ile Ile Ser Ser Leu Pro Ser Ile 
            420                 425                 430         


Val Asn Asp Lys Tyr Gly Arg Lys Val Leu Leu Tyr Leu Leu Ser Pro 
        435                 440                 445             


Arg Asp Pro Ala His Thr Val Arg Glu Ile Ile Glu Val Leu Gln Lys 
    450                 455                 460                 


Gly Asp Gly Asn Ala His Ser Lys Lys Asp Thr Glu Val Arg Arg Arg 
465                 470                 475                 480 


Glu Leu Leu Glu Ser Ile Ser Pro Ala Leu Leu Ser Tyr Leu Gln Glu 
                485                 490                 495     


His Ala Gln Glu Val Val Leu Asp Lys Ser Ala Cys Val Leu Val Ser 
            500                 505                 510         


Asp Ile Leu Gly Ser Ala Thr Gly Asp Val Gln Pro Thr Met Asn Ala 
        515                 520                 525             


Ile Ala Ser Leu Ala Ala Thr Gly Leu His Pro Gly Gly Lys Asp Gly 
    530                 535                 540                 


Glu Leu His Ile Ala Glu His Pro Ala Gly His Leu Val Leu Lys Trp 
545                 550                 555                 560 


Leu Ile Glu Gln Asp Lys Lys Met Lys Glu Asn Gly Arg Glu Gly Cys 
                565                 570                 575     


Phe Ala Lys Thr Leu Val Glu His Val Gly Met Lys Asn Leu Lys Ser 
            580                 585                 590         


Trp Ala Ser Val Asn Arg Gly Ala Ile Ile Leu Ser Ser Leu Leu Gln 
        595                 600                 605             


Ser Cys Asp Leu Glu Val Ala Asn Lys Val Lys Ala Ala Leu Lys Ser 
    610                 615                 620                 


Leu Ile Pro Thr Leu Glu Lys Thr Lys Ser Thr Ser Lys Gly Ile Glu 
625                 630                 635                 640 


Ile Leu Leu Glu Lys Leu Ser Thr 
                645             


<210>  5828
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0040__Homo_sapiens__NP_055471

<400>  5828

Met Glu Arg Ile Ser Ala Phe Phe Ser Ser Ile Trp Asp Thr Ile Leu 
1               5                   10                  15      


Thr Lys His Gln Glu Gly Ile Tyr Asn Thr Ile Cys Leu Gly Val Leu 
            20                  25                  30          


Leu Gly Leu Pro Leu Leu Val Ile Ile Thr Leu Leu Phe Ile Cys Cys 
        35                  40                  45              


His Cys Cys Trp Ser Pro Pro Gly Lys Arg Gly Gln Gln Pro Glu Lys 
    50                  55                  60                  


Asn Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Asp Glu Glu Asp Leu 
65                  70                  75                  80  


Trp Ile Ser Ala Gln Pro Lys Leu Leu Gln Met Glu Lys Arg Pro Ser 
                85                  90                  95      


Leu Pro Val 
            


<210>  5829
<211>  2235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0100__Homo_sapiens__NP_055495

<400>  5829

Met Pro Leu Phe Phe Ser Ala Leu Leu Val Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Arg Trp Leu Val Val Arg Leu Ala Thr Lys 
            20                  25                  30          


Trp Cys Gln Arg Lys Leu Gln Ala Glu Leu Lys Ile Gly Ser Phe Arg 
        35                  40                  45              


Phe Phe Trp Ile Gln Asn Val Ser Leu Lys Phe Gln Gln His Gln Gln 
    50                  55                  60                  


Thr Val Glu Ile Asp Asn Leu Trp Ile Ser Ser Lys Leu Leu Ser His 
65                  70                  75                  80  


Asp Leu Pro His Tyr Val Ala Leu Cys Phe Gly Glu Val Arg Ile Arg 
                85                  90                  95      


Thr Asp Leu Gln Lys Val Ser Asp Leu Ser Ala Pro Phe Ser Gln Ser 
            100                 105                 110         


Ala Gly Val Asp Gln Lys Glu Leu Ser Phe Ser Pro Ser Leu Leu Lys 
        115                 120                 125             


Ile Phe Cys Gln Leu Phe Ser Ile His Val Asp Ala Ile Asn Ile Met 
    130                 135                 140                 


Val Leu Lys Val Asp Thr Ser Glu Ser Leu Trp His Ile Gln Ile Ser 
145                 150                 155                 160 


Arg Ser Arg Phe Leu Leu Asp Ser Asp Gly Lys Arg Leu Ile Cys Glu 
                165                 170                 175     


Val Ser Leu Cys Lys Ile Asn Ser Lys Val Leu Lys Ser Gly Gln Leu 
            180                 185                 190         


Glu Asp Thr Cys Leu Val Glu Leu Ser Leu Ala Leu Asp Leu Cys Leu 
        195                 200                 205             


Lys Val Gly Ile Ser Ser Arg His Leu Thr Ala Ile Thr Val Asp Val 
    210                 215                 220                 


Trp Thr Leu His Ala Glu Leu His Glu Gly Leu Phe Gln Ser Gln Leu 
225                 230                 235                 240 


Leu Cys Gln Gly Pro Ser Leu Ala Ser Lys Pro Val Pro Cys Ser Glu 
                245                 250                 255     


Val Thr Glu Asn Leu Val Glu Pro Thr Leu Pro Gly Leu Phe Leu Leu 
            260                 265                 270         


Gln Gln Leu Pro Asp Gln Val Lys Val Lys Met Glu Asn Thr Ser Val 
        275                 280                 285             


Val Leu Ser Met Asn Ser Gln Lys Arg His Leu Thr Trp Thr Leu Lys 
    290                 295                 300                 


Leu Leu Gln Phe Leu Tyr His Arg Asp Glu Asp Gln Leu Pro Leu Arg 
305                 310                 315                 320 


Ser Phe Thr Ala Asn Ser Asp Met Ala Gln Met Ser Thr Glu Leu Leu 
                325                 330                 335     


Leu Glu Asp Gly Leu Leu Leu Ser Gln Ser Arg Gln Arg Ile Val Cys 
            340                 345                 350         


Leu Asn Ser Leu Lys Ala Ser Val Gln Val Thr Thr Ile Asp Leu Ser 
        355                 360                 365             


Ala Ser Leu Val Leu Asn Thr Cys Ile Ile His Tyr Arg His Gln Glu 
    370                 375                 380                 


Phe Ser His Trp Leu His Leu Leu Ala Leu Glu Thr Gln Gly Ser Ser 
385                 390                 395                 400 


Ser Pro Val Leu Lys Gln Arg Lys Lys Arg Thr Phe Pro Gln Ile Leu 
                405                 410                 415     


Ala Pro Ile Ile Phe Ser Thr Ser Ile Ser Asn Val Asn Ile Ser Ile 
            420                 425                 430         


Gln Leu Gly Asp Thr Pro Pro Phe Ala Leu Gly Phe Asn Ser Ile Ser 
        435                 440                 445             


Leu Asp Tyr Gln His Leu Arg Pro Gln Ser Ile His Gln Arg Gly Val 
    450                 455                 460                 


Leu Thr Val Asp His Leu Cys Trp Arg Val Gly Ser Asp Ser His Ile 
465                 470                 475                 480 


Gln Arg Ala Pro His Pro Pro Asn Met His Val Trp Gly Glu Ala Leu 
                485                 490                 495     


Val Leu Asp Ser Phe Thr Leu Gln Gly Ser Tyr Asn Gln Pro Leu Gly 
            500                 505                 510         


Leu Ser Ser Thr Gln Ser Asp Thr Leu Phe Leu Asp Cys Thr Ile Arg 
        515                 520                 525             


Gly Leu Gln Val Glu Ala Ser Asp Thr Cys Ala Gln Cys Leu Ser Arg 
    530                 535                 540                 


Ile Leu Ser Leu Met Gly Pro Gln Ser Gly Lys Ser Ala Val Ser Arg 
545                 550                 555                 560 


His Ser Ser Phe Gly Glu Ser Val Ser Leu Leu Trp Lys Val Asp Leu 
                565                 570                 575     


Lys Val Glu Asp Met Asn Leu Phe Thr Leu Ser Ala Leu Val Gly Ala 
            580                 585                 590         


Ser Glu Val Arg Leu Asp Thr Leu Thr Ile Leu Gly Ser Ala Glu Thr 
        595                 600                 605             


Ser Thr Val Gly Ile Gln Gly Leu Val Leu Ala Leu Val Lys Ser Val 
    610                 615                 620                 


Thr Glu Lys Met Gln Pro Cys Cys Lys Ala Pro Asp Ile Pro Thr Pro 
625                 630                 635                 640 


Val Leu Ser Leu Ser Met Leu Ser Ile Thr Tyr His Ser Ser Ile Arg 
                645                 650                 655     


Ser Leu Glu Val Gln Cys Gly Ala Gly Leu Thr Leu Leu Trp Ser Pro 
            660                 665                 670         


Pro Asp His Met Tyr Leu Tyr Gln His Val Leu Ala Thr Leu Gln Cys 
        675                 680                 685             


Arg Asp Leu Leu Arg Ala Thr Val Phe Pro Glu Thr Val Pro Ser Leu 
    690                 695                 700                 


Ala Leu Glu Thr Ser Gly Thr Thr Ser Glu Leu Glu Gly Arg Ala Pro 
705                 710                 715                 720 


Glu Pro Leu Pro Pro Lys Arg Leu Leu Asn Leu Thr Leu Glu Val Ser 
                725                 730                 735     


Thr Ala Lys Leu Thr Ala Phe Val Ala Glu Asp Lys Phe Ile Thr Leu 
            740                 745                 750         


Ala Ala Glu Ser Val Ser Leu Ser Arg His Gly Gly Ser Leu Gln Ala 
        755                 760                 765             


Tyr Cys Pro Glu Leu Ala Ala Gly Phe Asp Gly Asn Ser Ile Phe Asn 
    770                 775                 780                 


Phe Lys Glu Val Glu Val Gln Leu Leu Pro Glu Leu Glu Glu Met Ile 
785                 790                 795                 800 


Leu His Arg Asn Pro Phe Pro Ala Leu Gln Thr Leu Arg Asn Arg Val 
                805                 810                 815     


Trp Leu Leu Ser Phe Gly Ser Val Ser Val Glu Phe Pro Tyr Gln Tyr 
            820                 825                 830         


Asp Phe Ser Arg Thr Leu Asp Glu Ala Val Gly Val Gln Lys Trp Leu 
        835                 840                 845             


Lys Gly Leu His Gln Gly Thr Arg Ala Trp Ala Ser Pro Ser Pro Val 
    850                 855                 860                 


Pro Leu Pro Pro Asp Leu Leu Leu Lys Val Glu His Phe Ser Trp Val 
865                 870                 875                 880 


Phe Leu Asp Asp Val Phe Glu Val Lys Leu His Asp Asn Tyr Glu Leu 
                885                 890                 895     


Met Lys Asp Glu Ser Lys Glu Ser Ala Lys Arg Leu Gln Leu Leu Asp 
            900                 905                 910         


Ala Lys Val Ala Ala Leu Arg Lys Gln His Gly Glu Leu Leu Pro Ala 
        915                 920                 925             


Arg Lys Ile Glu Glu Leu Tyr Ala Ser Leu Glu Arg Lys Asn Ile Glu 
    930                 935                 940                 


Ile Tyr Ile Gln Arg Ser Arg Arg Leu Tyr Gly Asn Thr Pro Met Arg 
945                 950                 955                 960 


Arg Ala Leu Leu Thr Trp Ser Leu Ala Gly Leu Glu Leu Val Ala Leu 
                965                 970                 975     


Ala Asp Ala Ser Phe His Gly Pro Glu His Val Val Glu Gln Val Gln 
            980                 985                 990         


Glu Leu Asp Pro Gly Ser Pro Phe  Pro Pro Glu Gly Leu  Asp Leu Val 
        995                 1000                 1005             


Ile Gln  Trp Cys Arg Met Leu  Lys Cys Asn Val Lys  Ser Phe Leu 
    1010                 1015                 1020             


Val Arg  Ile Arg Asp Tyr Pro  Arg Tyr Leu Phe Glu  Ile Arg Asp 
    1025                 1030                 1035             


Trp Arg  Leu Met Gly Arg Leu  Val Gly Thr Glu Gln  Ser Gly Gln 
    1040                 1045                 1050             


Pro Cys  Ser Arg Arg Arg Gln  Ile Leu His Leu Gly  Leu Pro Trp 
    1055                 1060                 1065             


Gly Asn  Val Ala Val Glu Arg  Asn Met Pro Pro Leu  Lys Phe Tyr 
    1070                 1075                 1080             


His Asp  Phe His Ser Glu Ile  Phe Gln Tyr Thr Val  Val Trp Gly 
    1085                 1090                 1095             


Pro Cys  Trp Asp Pro Ala Trp  Thr Leu Ile Gly Gln  Cys Val Asp 
    1100                 1105                 1110             


Leu Leu  Thr Lys Pro Ser Ala  Asp Pro Ser Pro Pro  Leu Pro Trp 
    1115                 1120                 1125             


Trp Asp  Lys Ser Arg Leu Leu  Phe His Gly Asp Trp  His Met Asp 
    1130                 1135                 1140             


Ile Glu  Gln Ala Asn Leu His  Gln Leu Ala Thr Glu  Asp Pro Tyr 
    1145                 1150                 1155             


Asn Thr  Thr Glu Asn Met His  Trp Glu Trp Ser His  Leu Ser Phe 
    1160                 1165                 1170             


His Trp  Lys Pro Gly Gln Phe  Val Phe Lys Gly Asp  Leu Asp Ile 
    1175                 1180                 1185             


Asn Val  Arg Thr Ala Ser Lys  Tyr Asp Asp Cys Cys  Phe Leu His 
    1190                 1195                 1200             


Leu Pro  Asp Leu Cys Met Thr  Leu Asp Leu Gln Trp  Leu Cys His 
    1205                 1210                 1215             


Gly Asn  Pro His Asp His His  Ser Val Thr Leu Arg  Ala Pro Glu 
    1220                 1225                 1230             


Phe Leu  Pro Glu Val Pro Leu  Gly Gln Leu His Asp  Ser Tyr Arg 
    1235                 1240                 1245             


Ala Phe  Arg Ser Glu Asn Leu  Asn Leu Ser Ile Lys  Met Asp Leu 
    1250                 1255                 1260             


Thr Arg  His Ser Gly Thr Ile  Ser Gln Pro Arg Ile  Leu Leu Tyr 
    1265                 1270                 1275             


Ser Ser  Thr Leu Arg Trp Met  Gln Asn Phe Trp Ala  Thr Trp Thr 
    1280                 1285                 1290             


Ser Val  Thr Arg Pro Ile Cys  Arg Gly Lys Leu Phe  Asn Asn Leu 
    1295                 1300                 1305             


Lys Pro  Ser Lys Lys Lys Leu  Gly Gln His Tyr Lys  Gln Leu Ser 
    1310                 1315                 1320             


Tyr Thr  Ala Leu Phe Pro Gln  Leu Gln Val His Tyr  Trp Ala Ser 
    1325                 1330                 1335             


Phe Ala  Gln Gln Arg Gly Ile  Gln Ile Glu Cys Ser  Gln Gly His 
    1340                 1345                 1350             


Val Phe  Thr Arg Gly Thr Gln  Arg Leu Ile Pro Gln  Ala Gly Thr 
    1355                 1360                 1365             


Val Met  Arg Arg Leu Ile Ser  Asp Trp Ser Val Thr  Gln Met Val 
    1370                 1375                 1380             


Ser Asp  Leu Ser Gln Val Thr  Val His Leu Met Ala  Ser Pro Thr 
    1385                 1390                 1395             


Glu Glu  Asn Ala Asp His Cys  Leu Asp Pro Leu Val  Thr Lys Thr 
    1400                 1405                 1410             


His Leu  Leu Ser Leu Ser Ser  Leu Thr Tyr Gln Arg  His Ser Asn 
    1415                 1420                 1425             


Arg Thr  Ala Glu Glu Glu Leu  Ser Ala Arg Asp Gly  Asp Pro Thr 
    1430                 1435                 1440             


Phe His  Thr His Gln Leu His  Leu Val Asp Leu Arg  Ile Ser Trp 
    1445                 1450                 1455             


Thr Thr  Thr Asn Arg Asp Ile  Ala Phe Gly Leu Tyr  Asp Gly Tyr 
    1460                 1465                 1470             


Lys Lys  Ala Ala Val Leu Lys  Arg Asn Leu Ser Thr  Glu Ala Leu 
    1475                 1480                 1485             


Lys Gly  Leu Lys Ile Asp Pro  Gln Met Pro Ala Lys  Lys Pro Lys 
    1490                 1495                 1500             


Arg Gly  Val Pro Thr Ser Ala  Ser Ala Pro Pro Arg  Val Asn Thr 
    1505                 1510                 1515             


Pro Ser  Phe Ser Gly Gln Pro  Asp Lys Gly Ser Ser  Gly Gly Ala 
    1520                 1525                 1530             


Tyr Met  Leu Gln Lys Leu Ile  Glu Glu Thr Asp Arg  Phe Val Val 
    1535                 1540                 1545             


Phe Thr  Glu Glu Glu Ser Gly  Met Ser Asp Gln Leu  Cys Gly Ile 
    1550                 1555                 1560             


Ala Ala  Cys Gln Thr Asp Asp  Ile Tyr Asn Arg Asn  Cys Leu Ile 
    1565                 1570                 1575             


Glu Leu  Val Asn Cys Gln Met  Val Leu Arg Gly Ala  Glu Thr Glu 
    1580                 1585                 1590             


Gly Cys  Val Ile Val Ser Ala  Ala Lys Ala Gln Leu  Leu Gln Cys 
    1595                 1600                 1605             


Gln His  His Pro Ala Trp Tyr  Gly Asp Thr Leu Lys  Gln Lys Thr 
    1610                 1615                 1620             


Ser Trp  Thr Cys Leu Leu Asp  Gly Met Gln Tyr Phe  Ala Thr Thr 
    1625                 1630                 1635             


Glu Ser  Ser Pro Thr Glu Gln  Asp Gly Arg Gln Leu  Trp Leu Glu 
    1640                 1645                 1650             


Val Lys  Asn Ile Glu Glu His  Arg Gln Arg Ser Leu  Asp Ser Val 
    1655                 1660                 1665             


Gln Glu  Leu Met Glu Ser Gly  Gln Ala Val Gly Gly  Met Val Thr 
    1670                 1675                 1680             


Thr Thr  Thr Asp Trp Asn Gln  Pro Ala Glu Ala Gln  Gln Ala Gln 
    1685                 1690                 1695             


Gln Val  Gln Arg Ile Ile Ser  Arg Cys Asn Cys Arg  Met Tyr Tyr 
    1700                 1705                 1710             


Ile Ser  Tyr Ser His Asp Ile  Asp Pro Glu Leu Ala  Thr Gln Ile 
    1715                 1720                 1725             


Lys Pro  Pro Glu Val Leu Glu  Asn Gln Glu Lys Glu  Asp Leu Leu 
    1730                 1735                 1740             


Lys Lys  Gln Glu Gly Ala Val  Asp Thr Phe Thr Leu  Ile His His 
    1745                 1750                 1755             


Glu Leu  Glu Ile Ser Thr Asn  Pro Ala Gln Tyr Ala  Met Ile Leu 
    1760                 1765                 1770             


Asp Ile  Val Asn Asn Leu Leu  Leu His Val Glu Pro  Lys Arg Lys 
    1775                 1780                 1785             


Glu His  Ser Glu Lys Lys Gln  Arg Val Arg Phe Gln  Leu Glu Ile 
    1790                 1795                 1800             


Ser Ser  Asn Pro Glu Glu Gln  Arg Ser Ser Ile Leu  His Leu Gln 
    1805                 1810                 1815             


Glu Ala  Val Arg Gln His Val  Ala Gln Ile Arg Gln  Leu Glu Lys 
    1820                 1825                 1830             


Gln Met  Tyr Ser Ile Met Lys  Ser Leu Gln Asp Asp  Ser Lys Asn 
    1835                 1840                 1845             


Glu Asn  Leu Leu Asp Leu Asn  Gln Lys Leu Gln Leu  Gln Leu Asn 
    1850                 1855                 1860             


Gln Glu  Lys Ala Asn Leu Gln  Leu Glu Ser Glu Glu  Leu Asn Ile 
    1865                 1870                 1875             


Leu Ile  Arg Cys Phe Lys Asp  Phe Gln Leu Gln Arg  Ala Asn Lys 
    1880                 1885                 1890             


Met Glu  Leu Arg Lys Gln Gln  Glu Asp Val Ser Val  Val Arg Arg 
    1895                 1900                 1905             


Thr Glu  Phe Tyr Phe Ala Gln  Ala Arg Trp Arg Leu  Thr Glu Glu 
    1910                 1915                 1920             


Asp Gly  Gln Leu Gly Ile Ala  Glu Leu Glu Leu Gln  Arg Phe Leu 
    1925                 1930                 1935             


Tyr Ser  Lys Val Asn Lys Ser  Asp Asp Thr Ala Glu  His Leu Leu 
    1940                 1945                 1950             


Glu Leu  Gly Trp Phe Thr Met  Asn Asn Leu Leu Pro  Asn Ala Val 
    1955                 1960                 1965             


Tyr Lys  Val Val Leu Arg Pro  Gln Ser Ser Cys Gln  Ser Gly Arg 
    1970                 1975                 1980             


Gln Leu  Ala Leu Arg Leu Phe  Ser Lys Val Arg Pro  Pro Val Gly 
    1985                 1990                 1995             


Gly Ile  Ser Val Lys Glu His  Phe Glu Val Asn Val  Val Pro Leu 
    2000                 2005                 2010             


Thr Ile  Gln Leu Thr His Gln  Phe Phe His Arg Met  Met Gly Phe 
    2015                 2020                 2025             


Phe Phe  Pro Gly Arg Ser Val  Glu Asp Asp Glu Val  Gly Asp Glu 
    2030                 2035                 2040             


Glu Asp  Lys Ser Lys Leu Val  Thr Thr Gly Ile Pro  Val Val Lys 
    2045                 2050                 2055             


Pro Arg  Gln Leu Ile Ala Thr  Asp Asp Ala Val Pro  Leu Gly Pro 
    2060                 2065                 2070             


Gly Lys  Gly Val Ala Gln Gly  Leu Thr Arg Ser Ser  Gly Val Arg 
    2075                 2080                 2085             


Arg Ser  Phe Arg Lys Ser Pro  Glu His Pro Val Asp  Asp Ile Asp 
    2090                 2095                 2100             


Lys Met  Lys Glu Arg Ala Ala  Met Asn Asn Ser Phe  Ile Tyr Ile 
    2105                 2110                 2115             


Lys Ile  Pro Gln Val Pro Leu  Cys Val Ser Tyr Lys  Gly Glu Lys 
    2120                 2125                 2130             


Asn Ser  Val Asp Trp Gly Asp  Leu Asn Leu Val Leu  Pro Cys Leu 
    2135                 2140                 2145             


Glu Tyr  His Asn Asn Thr Trp  Thr Trp Leu Asp Phe  Ala Met Ala 
    2150                 2155                 2160             


Val Lys  Arg Asp Ser Arg Lys  Ala Leu Val Ala Gln  Val Ile Lys 
    2165                 2170                 2175             


Glu Lys  Leu Arg Leu Lys Ser  Ala Thr Gly Ser Glu  Val Arg Gly 
    2180                 2185                 2190             


Lys Leu  Glu Thr Lys Ser Asp  Leu Asn Met Gln Gln  Gln Glu Glu 
    2195                 2200                 2205             


Glu Glu  Lys Ala Arg Leu Leu  Ile Gly Leu Ser Val  Gly Asp Lys 
    2210                 2215                 2220             


Asn Pro  Gly Lys Lys Ser Ile  Phe Gly Arg Arg Lys  
    2225                 2230                 2235 


<210>  5830
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0101__Homo_sapiens__NP_001025160

<400>  5830

Met Val Arg Thr Lys Ala Asp Ser Val Pro Gly Thr Tyr Arg Lys Val 
1               5                   10                  15      


Val Ala Ala Arg Ala Pro Arg Lys Val Leu Gly Ser Ser Thr Ser Ala 
            20                  25                  30          


Thr Asn Ser Thr Ser Val Ser Ser Arg Lys Glu His Val Leu Cys Asn 
        35                  40                  45              


Leu Ile Thr Gln Met Met Lys Lys Asn Arg Thr Phe Ser Phe Ile Phe 
    50                  55                  60                  


Glu 
65  


<210>  5831
<211>  1159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0196__Homo_sapiens__NP_055661

<400>  5831

Met Leu Asp Phe Leu Ala Glu Asn Asn Leu Cys Gly Gln Ala Ile Leu 
1               5                   10                  15      


Arg Ile Val Ser Cys Gly Asn Ala Ile Ile Ala Glu Leu Leu Arg Leu 
            20                  25                  30          


Ser Glu Phe Ile Pro Ala Val Phe Arg Leu Lys Asp Arg Ala Asp Gln 
        35                  40                  45              


Gln Lys Tyr Gly Asp Ile Ile Phe Asp Phe Ser Tyr Phe Lys Gly Pro 
    50                  55                  60                  


Glu Leu Trp Glu Ser Lys Leu Asp Ala Lys Pro Glu Leu Gln Asp Leu 
65                  70                  75                  80  


Asp Glu Glu Phe Arg Glu Asn Asn Ile Glu Ile Val Thr Arg Phe Tyr 
                85                  90                  95      


Leu Ala Phe Gln Ser Val His Lys Tyr Ile Val Asp Leu Asn Arg Tyr 
            100                 105                 110         


Leu Asp Asp Leu Asn Glu Gly Val Tyr Ile Gln Gln Thr Leu Glu Thr 
        115                 120                 125             


Val Leu Leu Asn Glu Asp Gly Lys Gln Leu Leu Cys Glu Ala Leu Tyr 
    130                 135                 140                 


Leu Tyr Gly Val Met Leu Leu Val Ile Asp Gln Lys Ile Glu Gly Glu 
145                 150                 155                 160 


Val Arg Glu Arg Met Leu Val Ser Tyr Tyr Arg Tyr Ser Ala Ala Arg 
                165                 170                 175     


Ser Ser Ala Asp Ser Asn Met Asp Asp Ile Cys Lys Leu Leu Arg Ser 
            180                 185                 190         


Thr Gly Tyr Ser Ser Gln Pro Gly Ala Lys Arg Pro Ser Asn Tyr Pro 
        195                 200                 205             


Glu Ser Tyr Phe Gln Arg Val Pro Ile Asn Glu Ser Phe Ile Ser Met 
    210                 215                 220                 


Val Ile Gly Arg Leu Arg Ser Asp Asp Ile Tyr Asn Gln Val Ser Ala 
225                 230                 235                 240 


Tyr Pro Leu Pro Glu His Arg Ser Thr Ala Leu Ala Asn Gln Ala Ala 
                245                 250                 255     


Met Leu Tyr Val Ile Leu Tyr Phe Glu Pro Ser Ile Leu His Thr His 
            260                 265                 270         


Gln Ala Lys Met Arg Glu Ile Val Asp Lys Tyr Phe Pro Asp Asn Trp 
        275                 280                 285             


Val Ile Ser Ile Tyr Met Gly Ile Thr Val Asn Leu Val Asp Ala Trp 
    290                 295                 300                 


Glu Pro Tyr Lys Ala Ala Lys Thr Ala Leu Asn Asn Thr Leu Asp Leu 
305                 310                 315                 320 


Ser Asn Val Arg Glu Gln Ala Ser Arg Tyr Ala Thr Val Ser Glu Arg 
                325                 330                 335     


Val His Ala Gln Val Gln Gln Phe Leu Lys Glu Gly Tyr Leu Arg Glu 
            340                 345                 350         


Glu Met Val Leu Asp Asn Ile Pro Lys Leu Leu Asn Cys Leu Arg Asp 
        355                 360                 365             


Cys Asn Val Ala Ile Arg Trp Leu Met Leu His Thr Ala Asp Ser Ala 
    370                 375                 380                 


Cys Asp Pro Asn Asn Lys Arg Leu Arg Gln Ile Lys Asp Gln Ile Leu 
385                 390                 395                 400 


Thr Asp Ser Arg Tyr Asn Pro Arg Ile Leu Phe Gln Leu Leu Leu Asp 
                405                 410                 415     


Thr Ala Gln Phe Glu Phe Ile Leu Lys Glu Met Phe Lys Gln Met Leu 
            420                 425                 430         


Ser Glu Lys Gln Thr Lys Trp Glu His Tyr Lys Lys Glu Gly Ser Glu 
        435                 440                 445             


Arg Met Thr Glu Leu Ala Asp Val Phe Ser Gly Val Lys Pro Leu Thr 
    450                 455                 460                 


Arg Val Glu Lys Asn Glu Asn Leu Gln Ala Trp Phe Arg Glu Ile Ser 
465                 470                 475                 480 


Lys Gln Ile Leu Ser Leu Asn Tyr Asp Asp Ser Thr Ala Ala Gly Arg 
                485                 490                 495     


Lys Thr Val Gln Leu Ile Gln Ala Leu Glu Glu Val Gln Glu Phe His 
            500                 505                 510         


Gln Leu Glu Ser Asn Leu Gln Val Cys Gln Phe Leu Ala Asp Thr Arg 
        515                 520                 525             


Lys Phe Leu His Gln Met Ile Arg Thr Ile Asn Ile Lys Glu Glu Val 
    530                 535                 540                 


Leu Ile Thr Met Gln Ile Val Gly Asp Leu Ser Phe Ala Trp Gln Leu 
545                 550                 555                 560 


Ile Asp Ser Phe Thr Ser Ile Met Gln Glu Ser Ile Arg Val Asn Pro 
                565                 570                 575     


Ser Met Val Thr Lys Leu Arg Ala Thr Phe Leu Lys Leu Ala Ser Ala 
            580                 585                 590         


Leu Asp Leu Pro Leu Leu Arg Ile Asn Gln Ala Asn Ser Pro Asp Leu 
        595                 600                 605             


Leu Ser Val Ser Gln Tyr Tyr Ser Gly Glu Leu Val Ser Tyr Val Arg 
    610                 615                 620                 


Lys Val Leu Gln Ile Ile Pro Glu Ser Met Phe Thr Ser Leu Leu Lys 
625                 630                 635                 640 


Ile Ile Lys Leu Gln Thr His Asp Ile Ile Glu Val Pro Thr Arg Leu 
                645                 650                 655     


Asp Lys Asp Lys Leu Arg Asp Tyr Ala Gln Leu Gly Pro Arg Tyr Glu 
            660                 665                 670         


Val Ala Lys Leu Thr His Ala Ile Ser Ile Phe Thr Glu Gly Ile Leu 
        675                 680                 685             


Met Met Lys Thr Thr Leu Val Gly Ile Ile Lys Val Asp Pro Lys Gln 
    690                 695                 700                 


Leu Leu Glu Asp Gly Ile Arg Lys Glu Leu Val Lys Arg Val Ala Phe 
705                 710                 715                 720 


Ala Leu His Arg Gly Leu Ile Phe Asn Pro Arg Ala Lys Pro Ser Glu 
                725                 730                 735     


Leu Met Pro Lys Leu Lys Glu Leu Gly Ala Thr Met Asp Gly Phe His 
            740                 745                 750         


Arg Ser Phe Glu Tyr Ile Gln Asp Tyr Val Asn Ile Tyr Gly Leu Lys 
        755                 760                 765             


Ile Trp Gln Glu Glu Val Ser Arg Ile Ile Asn Tyr Asn Val Glu Gln 
    770                 775                 780                 


Glu Cys Asn Asn Phe Leu Arg Thr Lys Ile Gln Asp Trp Gln Ser Met 
785                 790                 795                 800 


Tyr Gln Ser Thr His Ile Pro Ile Pro Lys Phe Thr Pro Val Asp Glu 
                805                 810                 815     


Ser Val Thr Phe Ile Gly Arg Leu Cys Arg Glu Ile Leu Arg Ile Thr 
            820                 825                 830         


Asp Pro Lys Met Thr Cys His Ile Asp Gln Leu Asn Thr Trp Tyr Asp 
        835                 840                 845             


Met Lys Thr His Gln Glu Val Thr Ser Ser Arg Leu Phe Ser Glu Ile 
    850                 855                 860                 


Gln Thr Thr Leu Gly Thr Phe Gly Leu Asn Gly Leu Asp Arg Leu Leu 
865                 870                 875                 880 


Cys Phe Met Ile Val Lys Glu Leu Gln Asn Phe Leu Ser Met Phe Gln 
                885                 890                 895     


Lys Ile Ile Leu Arg Asp Arg Thr Val Gln Asp Thr Leu Lys Thr Leu 
            900                 905                 910         


Met Asn Ala Val Ser Pro Leu Lys Ser Ile Val Ala Asn Ser Asn Lys 
        915                 920                 925             


Ile Tyr Phe Ser Ala Ile Ala Lys Thr Gln Lys Ile Trp Thr Ala Tyr 
    930                 935                 940                 


Leu Glu Ala Ile Met Lys Val Gly Gln Met Gln Ile Leu Arg Gln Gln 
945                 950                 955                 960 


Ile Ala Asn Glu Leu Asn Tyr Ser Cys Arg Phe Asp Ser Lys His Leu 
                965                 970                 975     


Ala Ala Ala Leu Glu Asn Leu Asn Lys Ala Leu Leu Ala Asp Ile Glu 
            980                 985                 990         


Ala His Tyr Gln Asp Pro Ser Leu  Pro Tyr Pro Lys Glu  Asp Asn Thr 
        995                 1000                 1005             


Leu Leu  Tyr Glu Ile Thr Ala  Tyr Leu Glu Ala Ala  Gly Ile His 
    1010                 1015                 1020             


Asn Pro  Leu Asn Lys Ile Tyr  Ile Thr Thr Lys Arg  Leu Pro Tyr 
    1025                 1030                 1035             


Phe Pro  Ile Val Asn Phe Leu  Phe Leu Ile Ala Gln  Leu Pro Lys 
    1040                 1045                 1050             


Leu Gln  Tyr Asn Lys Asn Leu  Gly Met Val Cys Arg  Lys Pro Thr 
    1055                 1060                 1065             


Asp Pro  Val Asp Trp Pro Pro  Leu Val Leu Gly Leu  Leu Thr Leu 
    1070                 1075                 1080             


Leu Lys  Gln Phe His Ser Arg  Tyr Thr Glu Gln Phe  Leu Ala Leu 
    1085                 1090                 1095             


Ile Gly  Gln Phe Ile Cys Ser  Thr Val Glu Gln Cys  Thr Ser Gln 
    1100                 1105                 1110             


Lys Ile  Pro Glu Ile Pro Ala  Asp Val Val Gly Ala  Leu Leu Phe 
    1115                 1120                 1125             


Leu Glu  Asp Tyr Val Arg Tyr  Thr Lys Leu Pro Arg  Arg Val Ala 
    1130                 1135                 1140             


Glu Ala  His Val Pro Asn Phe  Ile Phe Asp Glu Phe  Arg Thr Val 
    1145                 1150                 1155             


Leu 
    


<210>  5832
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0226__Homo_sapiens__NP_001139114

<400>  5832

Met Gln Ser Ile Leu Tyr His Gly Leu Ile Arg Asp Gln Ala Cys Arg 
1               5                   10                  15      


Arg Gln Thr Asp Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser 
            20                  25                  30          


Pro His Ser Ala Leu His Val Glu Lys Phe Ile Ser Val His Glu Asn 
        35                  40                  45              


Asp Gln Ser Ser Ala Asp Gly Ala Ser Glu Arg Ala Val Ala Glu Leu 
    50                  55                  60                  


Trp Leu Gln His Ser Leu Gln Tyr His Cys Leu Ser Ala Gln Leu Arg 
65                  70                  75                  80  


Pro Leu Leu Gly Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Asp Ala 
                85                  90                  95      


Ala Phe Leu Leu Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu 
            100                 105                 110         


Glu Ala Val Glu Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala 
        115                 120                 125             


Ser Met Phe Ala Arg Lys His Glu Ser Pro Leu Leu Val Thr Lys Ser 
    130                 135                 140                 


Gln Ser Leu Thr Ala Leu Pro Ser Ser Thr Tyr Thr Pro Pro Asn Ser 
145                 150                 155                 160 


Tyr Ala Gln His Ser Tyr Phe Gly Ser Phe Ser Ser Leu His Gln Ser 
                165                 170                 175     


Val Pro Asn Asn Gly Ser Glu Arg Arg Ser Thr Ser Phe Pro Leu Ser 
            180                 185                 190         


Gly Pro Pro Arg Lys Pro Gln Glu Ser Arg Gly His Val Ser Pro Ala 
        195                 200                 205             


Glu Asp Gln Thr Ile Gln Ala Pro Pro Val Ser Val Ser Ala Leu Ala 
    210                 215                 220                 


Arg Asp Ser Pro Leu Thr Pro Asn Glu Met Ser Ser Ser Thr Leu Thr 
225                 230                 235                 240 


Ser Pro Ile Glu Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Gly 
                245                 250                 255     


Asp Ala Ser Glu Gly Pro Glu Tyr Leu Ala Ile Gly Asn Leu Asp Pro 
            260                 265                 270         


Arg Gly Arg Thr Ala Ser Cys Gln Ser His Ser Ser Asn Ala Glu Ser 
        275                 280                 285             


Ser Ser Ser Asn Leu Phe Ser Ser Ser Ser Ser Gln Lys Pro Asp Ser 
    290                 295                 300                 


Ala Ala Ser Ser Leu Gly Asp Gln Glu Gly Gly Gly Glu Ser Gln Leu 
305                 310                 315                 320 


Ser Ser Val Leu Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Leu Thr 
                325                 330                 335     


Val Thr Ser Gly Ala Lys Lys Ser His Ile Arg Ser His Ser Asp Thr 
            340                 345                 350         


Ser Ile Ala Ser Arg Gly Ala Pro Gly Gly Pro Arg Asn Ile Thr Ile 
        355                 360                 365             


Ile Val Glu Asp Pro Ile Ala Glu Ser Cys Asn Asp Lys Ala Lys Leu 
    370                 375                 380                 


Arg Gly Pro Leu Pro Tyr Ser Gly Gln Ser Ser Glu Val Ser Thr Pro 
385                 390                 395                 400 


Ser Ser Leu Tyr Met Glu Tyr Glu Gly Gly Arg Tyr Leu Cys Ser Gly 
                405                 410                 415     


Glu Gly Met Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr 
            420                 425                 430         


Leu Ser Glu Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn 
        435                 440                 445             


Ala His Phe Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met 
    450                 455                 460                 


Lys Cys Asn Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu 
465                 470                 475                 480 


Glu Asp Ser Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu 
                485                 490                 495     


Arg Arg Gln Gln Ile Arg Thr Lys Asn Leu Leu Pro Met Tyr Gln Glu 
            500                 505                 510         


Ala Glu His Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser 
        515                 520                 525             


Ser Arg Asp Ser Ala Gln Leu Ser Asp Ser Gly Ser Ala Asp Glu Val 
    530                 535                 540                 


Asp Glu Phe Glu Ile Gln Asp Ala Asp Ile Arg Arg Asn Thr Ala Ser 
545                 550                 555                 560 


Ser Ser Lys Ser Phe Val Ser Ser Gln Ser Phe Ser His Cys Phe Leu 
                565                 570                 575     


His Ser Thr Ser Ala Glu Ala Val Ala Met Gly Leu Leu Lys Gln Phe 
            580                 585                 590         


Glu Gly Met Gln Leu Pro Ala Ala Ser Glu Leu Glu Trp Leu Val Pro 
        595                 600                 605             


Glu His Asp Ala Pro Gln Lys Leu Leu Pro Ile Pro Asp Ser Leu Pro 
    610                 615                 620                 


Ile Ser Pro Asp Asp Gly Gln His Ala Asp Ile Tyr Lys Leu Arg Ile 
625                 630                 635                 640 


Arg Val Arg Gly Asn Leu Glu Trp Ala Pro Pro Arg Pro Gln Ile Ile 
                645                 650                 655     


Phe Asn Val His Pro Ala Pro Thr Arg Lys Ile Ala Val Ala Lys Gln 
            660                 665                 670         


Asn Tyr Arg Cys Ala Gly Cys Gly Ile Arg Thr Asp Pro Asp Tyr Ile 
        675                 680                 685             


Lys Arg Leu Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Gln Cys 
    690                 695                 700                 


Cys His Glu Asn Ala Gln Met Ala Ile Pro Ser Arg Val Leu Arg Lys 
705                 710                 715                 720 


Trp Asp Phe Ser Lys Tyr Tyr Val Ser Asn Phe Ser Lys Asp Leu Leu 
                725                 730                 735     


Ile Lys Ile Trp Asn Asp Pro Leu Phe Asn Val Gln Asp Ile Asn Ser 
            740                 745                 750         


Ala Leu Tyr Arg Lys Val Lys Leu Leu Asn Gln Val Arg Leu Leu Arg 
        755                 760                 765             


Val Gln Leu Cys His Met Lys Asn Met Phe Lys Thr Cys Arg Leu Ala 
    770                 775                 780                 


Lys Glu Leu Leu Asp Ser Phe Asp Thr Val Pro Gly His Leu Thr Glu 
785                 790                 795                 800 


Asp Leu His Leu Tyr Ser Leu Asn Asp Leu Thr Ala Thr Arg Lys Gly 
                805                 810                 815     


Glu Leu Gly Pro Arg Leu Ala Glu Leu Thr Arg Ala Gly Ala Thr His 
            820                 825                 830         


Val Glu Arg Cys Met Leu Cys Gln Ala Lys Gly Phe Ile Cys Glu Phe 
        835                 840                 845             


Cys Gln Asn Glu Asp Asp Ile Ile Phe Pro Phe Glu Leu His Lys Cys 
    850                 855                 860                 


Arg Thr Cys Glu Glu Cys Lys Ala Cys Tyr His Lys Ala Cys Phe Lys 
865                 870                 875                 880 


Ser Gly Ser Cys Pro Arg Cys Glu Arg Leu Gln Ala Arg Arg Glu Ala 
                885                 890                 895     


Leu Ala Arg Gln Ser Leu Glu Ser Tyr Leu Ser Asp Tyr Glu Glu Glu 
            900                 905                 910         


Pro Ala Glu Ala Leu Ala Leu Glu Ala Ala Val Leu Glu Ala Thr 
        915                 920                 925         


<210>  5833
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0226L__Homo_sapiens__NP_001273691

<400>  5833

Met Val Ser Gln Ser Thr Val Arg Gln Asp Ser Pro Val Glu Pro Trp 
1               5                   10                  15      


Glu Gly Ile Ser Asp His Ser Gly Ile Ile Asp Gly Ser Pro Arg Leu 
            20                  25                  30          


Leu Asn Thr Asp His Pro Pro Cys Gln Leu Asp Ile Arg Leu Met Arg 
        35                  40                  45              


His Lys Ala Val Trp Ile Asn Pro Gln Asp Val Gln Gln Gln Pro Gln 
    50                  55                  60                  


Asp Leu Gln Ser Gln Val Pro Ala Ala Gly Asn Ser Gly Thr His Phe 
65                  70                  75                  80  


Val Thr Asp Ala Ala Ser Pro Ser Gly Pro Ser Pro Ser Cys Leu Gly 
                85                  90                  95      


Asp Ser Leu Ala Glu Thr Thr Leu Ser Glu Asp Thr Thr Asp Ser Val 
            100                 105                 110         


Gly Ser Ala Ser Pro His Gly Ser Ser Glu Lys Ser Ser Ser Phe Ser 
        115                 120                 125             


Leu Ser Ser Thr Glu Val His Met Val Arg Pro Gly Tyr Ser His Arg 
    130                 135                 140                 


Val Ser Leu Pro Thr Ser Pro Gly Ile Leu Ala Thr Ser Pro Tyr Pro 
145                 150                 155                 160 


Glu Thr Asp Ser Ala Phe Phe Glu Pro Ser His Leu Thr Ser Ala Ala 
                165                 170                 175     


Asp Glu Gly Ala Val Gln Val Ser Arg Arg Thr Ile Ser Ser Asn Ser 
            180                 185                 190         


Phe Ser Pro Glu Val Phe Val Leu Pro Val Asp Val Glu Lys Glu Asn 
        195                 200                 205             


Ala His Phe Tyr Val Ala Asp Met Ile Ile Ser Ala Met Glu Lys Met 
    210                 215                 220                 


Lys Cys Asn Ile Leu Ser Gln Gln Gln Thr Glu Ser Trp Ser Lys Glu 
225                 230                 235                 240 


Val Ser Gly Leu Leu Gly Ser Asp Gln Pro Asp Ser Glu Met Thr Phe 
                245                 250                 255     


Asp Thr Asn Ile Lys Gln Glu Ser Gly Ser Ser Thr Ser Ser Tyr Ser 
            260                 265                 270         


Gly Tyr Glu Gly Cys Ala Val Leu Gln Val Ser Pro Val Thr Glu Thr 
        275                 280                 285             


Arg Thr Tyr His Asp Val Lys Glu Ile Cys Lys Cys Asp Val Asp Glu 
    290                 295                 300                 


Phe Val Ile Leu Glu Leu Gly Asp Phe Asn Asp Ile Thr Glu Thr Cys 
305                 310                 315                 320 


Ser Cys Ser Cys Ser Ser Ser Lys Ser Val Thr Tyr Glu Pro Asp Phe 
                325                 330                 335     


Asn Ser Ala Glu Leu Leu Ala Lys Glu Leu Tyr Arg Val Phe Gln Lys 
            340                 345                 350         


Cys Trp Ile Leu Ser Val Val Asn Ser Gln Leu Ala Gly Ser Leu Ser 
        355                 360                 365             


Ala Ala Gly Ser Ile Val Val Asn Glu Glu Cys Val Arg Lys Asp Phe 
    370                 375                 380                 


Glu Ser Ser Met Asn Val Val Gln Glu Ile Lys Phe Lys Ser Arg Ile 
385                 390                 395                 400 


Arg Gly Thr Glu Asp Trp Ala Pro Pro Arg Phe Gln Ile Ile Phe Asn 
                405                 410                 415     


Ile His Pro Pro Leu Lys Arg Asp Leu Val Val Ala Ala Gln Asn Phe 
            420                 425                 430         


Phe Cys Ala Gly Cys Gly Thr Pro Val Glu Pro Lys Phe Val Lys Arg 
        435                 440                 445             


Leu Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Asp Cys Cys His 
    450                 455                 460                 


Ser Tyr Ala Glu Ser Cys Ile Pro Ala Arg Ile Leu Met Met Trp Asp 
465                 470                 475                 480 


Phe Lys Lys Tyr Tyr Val Ser Asn Phe Ser Lys Gln Leu Leu Asp Ser 
                485                 490                 495     


Ile Trp His Gln Pro Ile Phe Asn Leu Leu Ser Ile Gly Gln Ser Leu 
            500                 505                 510         


Tyr Ala Lys Ala Lys Glu Leu Asp Arg Val Lys Glu Ile Gln Glu Gln 
        515                 520                 525             


Leu Phe His Ile Lys Lys Leu Leu Lys Thr Cys Arg Phe Ala Asn Ser 
    530                 535                 540                 


Cys Val Lys Glu Arg Ala Leu Phe Val Asn Phe Ala Arg Ile Arg Leu 
545                 550                 555                 560 


Ser Ser Ser His Phe Arg Gln Gln His Val Glu Asp Val Gln Arg Ala 
                565                 570                 575     


Gly Leu Ala Phe Thr Asn Ser Ala Ser Ser Pro Pro Ser Ala Pro Gly 
            580                 585                 590         


Val Arg Gly Ser Gln Arg Gly Glu Asn Phe Trp Lys Val Trp Pro Leu 
        595                 600                 605             


Gln Gln His Asp Ala Pro Glu Tyr Cys Glu Lys Asp Cys Ser Thr Cys 
    610                 615                 620                 


Leu Met Ile Thr Pro Ile Cys Val Tyr Tyr Trp 
625                 630                 635 


<210>  5834
<211>  1395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0232__Homo_sapiens__NP_001094060

<400>  5834

Met Tyr Pro Ile Cys Thr Val Val Val Asp Gly Leu Pro Ser Glu Ser 
1               5                   10                  15      


Ser Ser Ser Ser Tyr Pro Gly Pro Val Ser Val Ser Glu Met Ser Leu 
            20                  25                  30          


Leu His Ala Leu Gly Pro Val Gln Thr Trp Leu Gly Gln Glu Leu Glu 
        35                  40                  45              


Lys Cys Gly Ile Asp Ala Met Ile Tyr Thr Arg Tyr Val Leu Ser Leu 
    50                  55                  60                  


Leu Leu His Asp Ser Tyr Asp Tyr Asp Leu Gln Glu Gln Glu Asn Asp 
65                  70                  75                  80  


Ile Phe Leu Gly Trp Glu Lys Gly Ala Tyr Lys Lys Trp Gly Lys Ser 
                85                  90                  95      


Lys Lys Lys Cys Ser Asp Leu Thr Leu Glu Glu Met Lys Lys Gln Ala 
            100                 105                 110         


Ala Val Gln Cys Leu Arg Ser Ala Ser Asp Glu Ser Ser Gly Ile Glu 
        115                 120                 125             


Thr Leu Val Glu Glu Leu Cys Ser Arg Leu Lys Asp Leu Gln Ser Lys 
    130                 135                 140                 


Gln Glu Glu Lys Ile His Lys Lys Leu Glu Gly Ser Pro Ser Pro Glu 
145                 150                 155                 160 


Ala Glu Leu Ser Pro Pro Ala Lys Asp Gln Val Glu Met Tyr Tyr Glu 
                165                 170                 175     


Ala Phe Pro Pro Leu Ser Glu Lys Pro Val Cys Leu Gln Glu Ile Met 
            180                 185                 190         


Thr Val Trp Asn Lys Ser Lys Val Cys Ser Tyr Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Ser Thr Ala Pro Pro Ala Ser Thr Asp Thr Ser Ser Pro Lys Asp 
    210                 215                 220                 


Cys Asn Ser Glu Ser Glu Val Thr Lys Glu Arg Ser Ser Glu Val Pro 
225                 230                 235                 240 


Thr Thr Val His Glu Lys Thr Gln Ser Lys Ser Lys Asn Glu Lys Glu 
                245                 250                 255     


Asn Lys Phe Ser Asn Gly Thr Ile Glu Glu Lys Pro Ala Leu Tyr Lys 
            260                 265                 270         


Lys Gln Ile Arg His Lys Pro Glu Gly Lys Ile Arg Pro Arg Ser Trp 
        275                 280                 285             


Ser Ser Gly Ser Ser Glu Ala Gly Ser Ser Ser Ser Gly Asn Gln Gly 
    290                 295                 300                 


Glu Leu Lys Ala Ser Met Lys Tyr Val Lys Val Arg His Lys Ala Arg 
305                 310                 315                 320 


Glu Ile Arg Asn Lys Lys Gly Arg Asn Gly Gln Ser Arg Leu Ser Leu 
                325                 330                 335     


Lys His Gly Glu Lys Ala Glu Arg Asn Ile His Thr Gly Ser Ser Ser 
            340                 345                 350         


Ser Ser Ser Ser Gly Ser Val Lys Gln Leu Cys Lys Arg Gly Lys Arg 
        355                 360                 365             


Pro Leu Lys Glu Ile Gly Arg Lys Asp Pro Gly Ser Thr Glu Gly Lys 
    370                 375                 380                 


Asp Leu Tyr Met Glu Asn Arg Lys Asp Thr Glu Tyr Lys Glu Glu Pro 
385                 390                 395                 400 


Leu Trp Tyr Thr Glu Pro Ile Ala Glu Tyr Phe Val Pro Leu Ser Arg 
                405                 410                 415     


Lys Ser Lys Leu Glu Thr Thr Tyr Arg Asn Arg Gln Asp Thr Ser Asp 
            420                 425                 430         


Leu Thr Ser Glu Ala Val Glu Glu Leu Ser Glu Ser Val His Gly Leu 
        435                 440                 445             


Cys Ile Ser Asn Asn Asn Leu His Lys Thr Tyr Leu Ala Ala Gly Thr 
    450                 455                 460                 


Phe Ile Asp Gly His Phe Val Glu Met Pro Ala Val Ile Asn Glu Asp 
465                 470                 475                 480 


Ile Asp Leu Thr Gly Thr Ser Leu Cys Ser Leu Pro Glu Asp Asn Lys 
                485                 490                 495     


Tyr Leu Asp Asp Ile His Leu Ser Glu Leu Thr His Phe Tyr Glu Val 
            500                 505                 510         


Asp Ile Asp Gln Ser Met Leu Asp Pro Gly Ala Ser Glu Thr Met Gln 
        515                 520                 525             


Gly Glu Ser Arg Ile Leu Asn Met Ile Arg Gln Lys Ser Lys Glu Asn 
    530                 535                 540                 


Thr Asp Phe Glu Ala Glu Cys Cys Ile Val Leu Asp Gly Met Glu Leu 
545                 550                 555                 560 


Gln Gly Glu Arg Ala Ile Trp Thr Asp Ser Thr Ser Ser Val Gly Ala 
                565                 570                 575     


Glu Gly Leu Phe Leu Gln Asp Leu Gly Asn Leu Ala Gln Phe Trp Glu 
            580                 585                 590         


Cys Cys Ser Ser Ser Ser Gly Asp Ala Asp Gly Glu Ser Phe Gly Gly 
        595                 600                 605             


Asp Ser Pro Val Arg Leu Ser Pro Ile Leu Asp Ser Thr Val Leu Asn 
    610                 615                 620                 


Ser His Leu Leu Ala Gly Asn Gln Glu Leu Phe Ser Asp Ile Asn Glu 
625                 630                 635                 640 


Gly Ser Gly Ile Asn Ser Cys Phe Ser Val Phe Glu Val Gln Cys Ser 
                645                 650                 655     


Asn Ser Val Leu Pro Phe Ser Phe Glu Thr Leu Asn Leu Gly Asn Glu 
            660                 665                 670         


Asn Thr Asp Ser Ser Ala Asn Met Leu Gly Lys Thr Gln Ser Arg Leu 
        675                 680                 685             


Leu Ile Trp Thr Lys Asn Ser Ala Phe Glu Glu Asn Glu His Cys Ser 
    690                 695                 700                 


Asn Leu Ser Thr Arg Thr Cys Ser Pro Trp Ser His Ser Glu Glu Thr 
705                 710                 715                 720 


Arg Ser Asp Asn Glu Thr Leu Asn Ile Gln Phe Glu Glu Ser Thr Gln 
                725                 730                 735     


Phe Asn Ala Glu Asp Ile Asn Tyr Val Val Pro Arg Val Ser Ser Asn 
            740                 745                 750         


Tyr Val Asp Glu Glu Leu Leu Asp Phe Leu Gln Asp Glu Thr Cys Gln 
        755                 760                 765             


Gln Asn Ser Arg Thr Leu Gly Glu Ile Pro Thr Leu Val Phe Lys Lys 
    770                 775                 780                 


Thr Ser Lys Leu Glu Ser Val Cys Gly Ile Gln Leu Glu Gln Lys Thr 
785                 790                 795                 800 


Glu Asn Lys Asn Phe Glu Thr Thr Gln Val Cys Asn Glu Ser Pro His 
                805                 810                 815     


Gly Asp Gly Tyr Ser Ser Gly Val Ile Lys Asp Ile Trp Thr Lys Met 
            820                 825                 830         


Ala Asp Thr Asn Ser Val Ala Thr Val Glu Ile Glu Arg Thr Asp Ala 
        835                 840                 845             


Glu Leu Phe Ser Ala Asp Val Asn Asn Tyr Cys Cys Cys Leu Asp Ala 
    850                 855                 860                 


Glu Ala Glu Leu Glu Thr Leu Gln Glu Pro Asp Lys Ala Val Arg Arg 
865                 870                 875                 880 


Ser Glu Tyr His Leu Trp Glu Gly Gln Lys Glu Ser Leu Glu Lys Arg 
                885                 890                 895     


Ala Phe Ala Ser Ser Glu Leu Ser Asn Val Asp Gly Gly Asp Tyr Thr 
            900                 905                 910         


Thr Pro Ser Lys Pro Trp Asp Val Ala Gln Asp Lys Glu Asn Thr Phe 
        915                 920                 925             


Ile Leu Gly Gly Val Tyr Gly Glu Leu Lys Thr Phe Asn Ser Asp Gly 
    930                 935                 940                 


Glu Trp Ala Val Val Pro Pro Ser His Thr Lys Gly Ser Leu Leu Gln 
945                 950                 955                 960 


Cys Ala Ala Ser Asp Val Val Thr Ile Ala Gly Thr Asp Val Phe Met 
                965                 970                 975     


Thr Pro Gly Asn Ser Phe Ala Pro Gly His Arg Gln Leu Trp Lys Pro 
            980                 985                 990         


Phe Val Ser Phe Glu Gln Asn Asp  Gln Pro Lys Ser Gly  Glu Asn Gly 
        995                 1000                 1005             


Leu Asn  Lys Gly Phe Ser Phe  Ile Phe His Glu Asp  Leu Leu Gly 
    1010                 1015                 1020             


Ala Cys  Gly Asn Phe Gln Val  Glu Asp Pro Gly Leu  Glu Tyr Ser 
    1025                 1030                 1035             


Phe Ser  Ser Phe Asp Leu Ser  Asn Pro Phe Ser Gln  Val Leu His 
    1040                 1045                 1050             


Val Glu  Cys Ser Phe Glu Pro  Glu Gly Ile Ala Ser  Phe Ser Pro 
    1055                 1060                 1065             


Ser Phe  Lys Pro Lys Ser Ile  Leu Cys Ser Asp Ser  Asp Ser Glu 
    1070                 1075                 1080             


Val Phe  His Pro Arg Ile Cys  Gly Val Asp Arg Thr  Gln Tyr Arg 
    1085                 1090                 1095             


Ala Ile  Arg Ile Ser Pro Arg  Thr His Phe Arg Pro  Ile Ser Ala 
    1100                 1105                 1110             


Ser Glu  Leu Ser Pro Gly Gly  Gly Ser Glu Ser Glu  Phe Glu Ser 
    1115                 1120                 1125             


Glu Lys  Asp Glu Ala Asn Ile  Pro Ile Pro Ser Gln  Val Asp Ile 
    1130                 1135                 1140             


Phe Glu  Asp Pro Gln Ala Asp  Leu Lys Pro Leu Glu  Glu Asp Ala 
    1145                 1150                 1155             


Glu Lys  Glu Gly His Tyr Tyr  Gly Lys Ser Glu Leu  Glu Ser Gly 
    1160                 1165                 1170             


Lys Phe  Leu Pro Arg Leu Lys  Lys Ser Gly Met Glu  Lys Ser Ala 
    1175                 1180                 1185             


Gln Thr  Ser Leu Asp Ser Gln  Glu Glu Ser Thr Gly  Ile Leu Ser 
    1190                 1195                 1200             


Val Gly  Lys Gln Asn Gln Cys  Leu Glu Cys Ser Met  Asn Glu Ser 
    1205                 1210                 1215             


Leu Glu  Ile Asp Leu Glu Ser  Ser Glu Ala Asn Cys  Lys Ile Met 
    1220                 1225                 1230             


Ala Gln  Cys Glu Glu Glu Ile  Asn Asn Phe Cys Gly  Cys Lys Ala 
    1235                 1240                 1245             


Gly Cys  Gln Phe Pro Ala Tyr  Glu Asp Asn Pro Val  Ser Ser Gly 
    1250                 1255                 1260             


Gln Leu  Glu Glu Phe Pro Val  Leu Asn Thr Asp Ile  Gln Gly Met 
    1265                 1270                 1275             


Asn Arg  Ser Gln Glu Lys Gln  Thr Trp Trp Glu Lys  Ala Leu Tyr 
    1280                 1285                 1290             


Ser Pro  Leu Phe Pro Ala Ser  Glu Cys Glu Glu Cys  Tyr Thr Asn 
    1295                 1300                 1305             


Ala Lys  Gly Glu Ser Gly Leu  Glu Glu Tyr Pro Asp  Ala Lys Glu 
    1310                 1315                 1320             


Thr Pro  Ser Asn Glu Glu Arg  Leu Leu Asp Phe Asn  Arg Val Ser 
    1325                 1330                 1335             


Ser Val  Tyr Glu Ala Arg Cys  Thr Gly Glu Arg Asp  Ser Gly Ala 
    1340                 1345                 1350             


Lys Ser  Asp Gly Phe Arg Gly  Lys Met Cys Ser Ser  Ala Ser Ser 
    1355                 1360                 1365             


Thr Ser  Glu Glu Thr Gly Ser  Glu Gly Gly Gly Glu  Trp Val Gly 
    1370                 1375                 1380             


Pro Ser  Glu Glu Glu Leu Phe  Ser Arg Thr His Leu  
    1385                 1390                 1395 


<210>  5835
<211>  1063
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0319__Homo_sapiens__NP_001161846

<400>  5835

Met Thr Arg Leu Gly Trp Pro Ser Pro Cys Cys Ala Arg Lys Gln Cys 
1               5                   10                  15      


Ser Glu Gly Arg Thr Tyr Ser Asn Ala Val Ile Ser Pro Asn Leu Glu 
            20                  25                  30          


Thr Thr Arg Ile Met Arg Val Ser His Thr Phe Pro Val Val Asp Cys 
        35                  40                  45              


Thr Ala Ala Cys Cys Asp Leu Ser Ser Cys Asp Leu Ala Trp Trp Phe 
    50                  55                  60                  


Glu Gly Arg Cys Tyr Leu Val Ser Cys Pro His Lys Glu Asn Cys Glu 
65                  70                  75                  80  


Pro Lys Lys Met Gly Pro Ile Arg Ser Tyr Leu Thr Phe Val Leu Arg 
                85                  90                  95      


Pro Val Gln Arg Pro Ala Gln Leu Leu Asp Tyr Gly Asp Met Met Leu 
            100                 105                 110         


Asn Arg Gly Ser Pro Ser Gly Ile Trp Gly Asp Ser Pro Glu Asp Ile 
        115                 120                 125             


Arg Lys Asp Leu Thr Phe Leu Gly Lys Asp Trp Gly Leu Glu Glu Met 
    130                 135                 140                 


Ser Glu Tyr Ser Asp Asp Tyr Arg Glu Leu Glu Lys Asp Leu Leu Gln 
145                 150                 155                 160 


Pro Ser Gly Lys Gln Glu Pro Arg Gly Ser Ala Glu Tyr Thr Asp Trp 
                165                 170                 175     


Gly Leu Leu Pro Gly Ser Glu Gly Ala Phe Asn Ser Ser Val Gly Asp 
            180                 185                 190         


Ser Pro Ala Val Pro Ala Glu Thr Gln Gln Asp Pro Glu Leu His Tyr 
        195                 200                 205             


Leu Asn Glu Ser Ala Ser Thr Pro Ala Pro Lys Leu Pro Glu Arg Ser 
    210                 215                 220                 


Val Leu Leu Pro Leu Pro Thr Thr Pro Ser Ser Gly Glu Val Leu Glu 
225                 230                 235                 240 


Lys Glu Lys Ala Ser Gln Leu Gln Glu Gln Ser Ser Asn Ser Ser Gly 
                245                 250                 255     


Lys Glu Val Leu Met Pro Ser His Ser Leu Pro Pro Ala Ser Leu Glu 
            260                 265                 270         


Leu Ser Ser Val Thr Val Glu Lys Ser Pro Val Leu Thr Val Thr Pro 
        275                 280                 285             


Gly Ser Thr Glu His Ser Ile Pro Thr Pro Pro Thr Ser Ala Ala Pro 
    290                 295                 300                 


Ser Glu Ser Thr Pro Ser Glu Leu Pro Ile Ser Pro Thr Thr Ala Pro 
305                 310                 315                 320 


Arg Thr Val Lys Glu Leu Thr Val Ser Ala Gly Asp Asn Leu Ile Ile 
                325                 330                 335     


Thr Leu Pro Asp Asn Glu Val Glu Leu Lys Ala Phe Val Ala Pro Ala 
            340                 345                 350         


Pro Pro Val Glu Thr Thr Tyr Asn Tyr Glu Trp Asn Leu Ile Ser His 
        355                 360                 365             


Pro Thr Asp Tyr Gln Gly Glu Ile Lys Gln Gly His Lys Gln Thr Leu 
    370                 375                 380                 


Asn Leu Ser Gln Leu Ser Val Gly Leu Tyr Val Phe Lys Val Thr Val 
385                 390                 395                 400 


Ser Ser Glu Asn Ala Phe Gly Glu Gly Phe Val Asn Val Thr Val Lys 
                405                 410                 415     


Pro Ala Arg Arg Val Asn Leu Pro Pro Val Ala Val Val Ser Pro Gln 
            420                 425                 430         


Leu Gln Glu Leu Thr Leu Pro Leu Thr Ser Ala Leu Ile Asp Gly Ser 
        435                 440                 445             


Gln Ser Thr Asp Asp Thr Glu Ile Val Ser Tyr His Trp Glu Glu Ile 
    450                 455                 460                 


Asn Gly Pro Phe Ile Glu Glu Lys Thr Ser Val Asp Ser Pro Val Leu 
465                 470                 475                 480 


Arg Leu Ser Asn Leu Asp Pro Gly Asn Tyr Ser Phe Arg Leu Thr Val 
                485                 490                 495     


Thr Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Ala Leu Ile Val 
            500                 505                 510         


Asn Asn Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn His 
        515                 520                 525             


Thr Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Asn Gly Asn Gln Ser 
    530                 535                 540                 


Ser Asp Asp His Gln Ile Val Leu Tyr Glu Trp Ser Leu Gly Pro Gly 
545                 550                 555                 560 


Ser Glu Gly Lys His Val Val Met Gln Gly Val Gln Thr Pro Tyr Leu 
                565                 570                 575     


His Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Phe Gln Leu Lys Val 
            580                 585                 590         


Thr Asp Ser Ser Arg Gln Gln Ser Thr Ala Val Val Thr Val Ile Val 
        595                 600                 605             


Gln Pro Glu Asn Asn Arg Pro Pro Val Ala Val Ala Gly Pro Asp Lys 
    610                 615                 620                 


Glu Leu Ile Phe Pro Val Glu Ser Ala Thr Leu Asp Gly Ser Ser Ser 
625                 630                 635                 640 


Ser Asp Asp His Gly Ile Val Phe Tyr His Trp Glu His Val Arg Gly 
                645                 650                 655     


Pro Ser Ala Val Glu Met Glu Asn Ile Asp Lys Ala Ile Ala Thr Val 
            660                 665                 670         


Thr Gly Leu Gln Val Gly Thr Tyr His Phe Arg Leu Thr Val Lys Asp 
        675                 680                 685             


Gln Gln Gly Leu Ser Ser Thr Ser Thr Leu Thr Val Ala Val Lys Lys 
    690                 695                 700                 


Glu Asn Asn Ser Pro Pro Arg Ala Arg Ala Gly Gly Arg His Val Leu 
705                 710                 715                 720 


Val Leu Pro Asn Asn Ser Ile Thr Leu Asp Gly Ser Arg Ser Thr Asp 
                725                 730                 735     


Asp Gln Arg Ile Val Ser Tyr Leu Trp Ile Arg Asp Gly Gln Ser Pro 
            740                 745                 750         


Ala Ala Gly Asp Val Ile Asp Gly Ser Asp His Ser Val Ala Leu Gln 
        755                 760                 765             


Leu Thr Asn Leu Val Glu Gly Val Tyr Thr Phe His Leu Arg Val Thr 
    770                 775                 780                 


Asp Ser Gln Gly Ala Ser Asp Thr Asp Thr Ala Thr Val Glu Val Gln 
785                 790                 795                 800 


Pro Asp Pro Arg Lys Ser Gly Leu Val Glu Leu Thr Leu Gln Val Gly 
                805                 810                 815     


Val Gly Gln Leu Thr Glu Gln Arg Lys Asp Thr Leu Val Arg Gln Leu 
            820                 825                 830         


Ala Val Leu Leu Asn Val Leu Asp Ser Asp Ile Lys Val Gln Lys Ile 
        835                 840                 845             


Arg Ala His Ser Asp Leu Ser Thr Val Ile Val Phe Tyr Val Gln Ser 
    850                 855                 860                 


Arg Pro Pro Phe Lys Val Leu Lys Ala Ala Glu Val Ala Arg Asn Leu 
865                 870                 875                 880 


His Met Arg Leu Ser Lys Glu Lys Ala Asp Phe Leu Leu Phe Lys Val 
                885                 890                 895     


Leu Arg Val Asp Thr Ala Gly Cys Leu Leu Lys Cys Ser Gly His Gly 
            900                 905                 910         


His Cys Asp Pro Leu Thr Lys Arg Cys Ile Cys Ser His Leu Trp Met 
        915                 920                 925             


Glu Asn Leu Ile Gln Arg Tyr Ile Trp Asp Gly Glu Ser Asn Cys Glu 
    930                 935                 940                 


Trp Ser Ile Phe Tyr Val Thr Val Leu Ala Phe Thr Leu Ile Val Leu 
945                 950                 955                 960 


Thr Gly Gly Phe Thr Trp Leu Cys Ile Cys Cys Cys Lys Arg Gln Lys 
                965                 970                 975     


Arg Thr Lys Ile Arg Lys Lys Thr Lys Tyr Thr Ile Leu Asp Asn Met 
            980                 985                 990         


Asp Glu Gln Glu Arg Met Glu Leu  Arg Pro Lys Tyr Gly  Ile Lys His 
        995                 1000                 1005             


Arg Ser  Thr Glu His Asn Ser  Ser Leu Met Val Ser  Glu Ser Glu 
    1010                 1015                 1020             


Phe Asp  Ser Asp Gln Asp Thr  Ile Phe Ser Arg Glu  Lys Met Glu 
    1025                 1030                 1035             


Arg Gly  Asn Pro Lys Val Ser  Met Asn Gly Ser Ile  Arg Asn Gly 
    1040                 1045                 1050             


Ala Ser  Phe Ser Tyr Cys Ser  Lys Asp Arg 
    1055                 1060             


<210>  5836
<211>  848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0319L__Homo_sapiens__XP_011540484

<400>  5836

Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu 
1               5                   10                  15      


Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr 
            20                  25                  30          


Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp 
        35                  40                  45              


Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly 
    50                  55                  60                  


Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro 
65                  70                  75                  80  


Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His 
                85                  90                  95      


Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg 
            100                 105                 110         


Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu 
        115                 120                 125             


Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro 
    130                 135                 140                 


Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser 
145                 150                 155                 160 


Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser 
                165                 170                 175     


Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro 
            180                 185                 190         


Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp 
        195                 200                 205             


Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His 
    210                 215                 220                 


Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu 
225                 230                 235                 240 


Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu 
                245                 250                 255     


Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys 
            260                 265                 270         


Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala 
        275                 280                 285             


Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro 
    290                 295                 300                 


Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr 
305                 310                 315                 320 


Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro 
                325                 330                 335     


Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro 
            340                 345                 350         


Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys 
        355                 360                 365             


Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu 
    370                 375                 380                 


Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro 
385                 390                 395                 400 


Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe 
                405                 410                 415     


Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln 
            420                 425                 430         


Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys 
        435                 440                 445             


Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys 
    450                 455                 460                 


Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val 
465                 470                 475                 480 


Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn 
                485                 490                 495     


Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val 
            500                 505                 510         


Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr 
        515                 520                 525             


Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser 
    530                 535                 540                 


Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln 
545                 550                 555                 560 


Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr 
                565                 570                 575     


Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln 
            580                 585                 590         


Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu 
        595                 600                 605             


Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser 
    610                 615                 620                 


Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro 
625                 630                 635                 640 


Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr 
                645                 650                 655     


Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu 
            660                 665                 670         


Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu 
        675                 680                 685             


Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr 
    690                 695                 700                 


Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp 
705                 710                 715                 720 


Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala 
                725                 730                 735     


Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu 
            740                 745                 750         


Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp 
        755                 760                 765             


Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro 
    770                 775                 780                 


Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val 
785                 790                 795                 800 


Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly 
                805                 810                 815     


Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln 
            820                 825                 830         


Pro Tyr Thr Glu Gln Arg Lys Ile Ser Ser Val Glu Ala Ser Leu Lys 
        835                 840                 845             


<210>  5837
<211>  1070
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0355__Homo_sapiens__NP_055501

<400>  5837

Met Tyr Cys Cys Ser Ala Gln Asp Ser Lys Met Asp Tyr Lys Arg Arg 
1               5                   10                  15      


Phe Leu Leu Gly Gly Ser Lys Gln Lys Val Gln Gln His Gln Gln Tyr 
            20                  25                  30          


Pro Met Pro Glu Leu Gly Arg Ala Leu Ser Ala Pro Leu Ala Ser Thr 
        35                  40                  45              


Ala Thr Thr Ala Pro Leu Gly Ser Leu Thr Ala Ala Gly Ser Cys His 
    50                  55                  60                  


His Ala Met Pro His Thr Thr Pro Ile Ala Asp Ile Gln Gln Gly Ile 
65                  70                  75                  80  


Ser Lys Tyr Leu Asp Ala Leu Asn Val Phe Cys Arg Ala Ser Thr Phe 
                85                  90                  95      


Leu Thr Asp Leu Phe Ser Thr Val Phe Arg Asn Ser His Tyr Ser Lys 
            100                 105                 110         


Ala Ala Thr Gln Leu Lys Asp Val Gln Glu His Val Met Glu Ala Ala 
        115                 120                 125             


Ser Arg Leu Thr Ser Ala Ile Lys Pro Glu Ile Ala Lys Met Leu Met 
    130                 135                 140                 


Glu Leu Ser Ala Gly Ala Ala Asn Phe Thr Asp Gln Lys Glu Phe Ser 
145                 150                 155                 160 


Leu Gln Asp Ile Glu Val Leu Gly Arg Cys Phe Leu Thr Val Val Gln 
                165                 170                 175     


Val His Phe Gln Phe Leu Thr His Ala Leu Gln Lys Val Gln Pro Val 
            180                 185                 190         


Ala His Ser Cys Phe Ala Glu Val Ile Val Pro Glu Lys Lys Asn Ser 
        195                 200                 205             


Gly Ser Gly Gly Gly Leu Ser Gly Met Gly His Thr Pro Glu Val Glu 
    210                 215                 220                 


Glu Ala Val Arg Ser Trp Arg Gly Ala Ala Glu Ala Thr Ser Arg Leu 
225                 230                 235                 240 


Arg Glu Arg Gly Cys Asp Gly Cys Leu Ala Gly Ile Glu Val Gln Gln 
                245                 250                 255     


Leu Phe Cys Ser Gln Ser Ala Ala Ile Pro Glu His Gln Leu Lys Glu 
            260                 265                 270         


Leu Asn Ile Lys Ile Asp Ser Ala Leu Gln Ala Tyr Lys Ile Ala Leu 
        275                 280                 285             


Glu Ser Leu Gly His Cys Glu Tyr Ala Met Lys Ala Gly Phe His Leu 
    290                 295                 300                 


Asn Pro Lys Ala Ile Glu Ala Ser Leu Gln Gly Cys Cys Ser Glu Ala 
305                 310                 315                 320 


Glu Ala Gln Gln Thr Gly Arg Arg Gln Thr Pro Pro Gln Pro Met Gln 
                325                 330                 335     


Cys Glu Leu Pro Thr Val Pro Val Gln Ile Gly Ser His Phe Leu Lys 
            340                 345                 350         


Gly Val Ser Phe Asn Glu Ser Ala Ala Asp Asn Leu Lys Leu Lys Thr 
        355                 360                 365             


His Thr Met Leu Gln Leu Met Lys Glu Ala Gly Cys Tyr Asn Gly Ile 
    370                 375                 380                 


Thr Ser Arg Asp Asp Phe Pro Val Thr Glu Val Leu Asn Gln Val Cys 
385                 390                 395                 400 


Pro Ser Thr Trp Arg Gly Ala Cys Lys Thr Ala Val Gln Leu Leu Phe 
                405                 410                 415     


Gly Gln Ala Gly Leu Val Val Val Asp Thr Ala Gln Ile Glu Asn Lys 
            420                 425                 430         


Glu Ala Tyr Ala Pro Gln Ile Ser Leu Glu Gly Ser Arg Ile Val Val 
        435                 440                 445             


Gln Val Pro Ser Thr Trp Cys Leu Lys Glu Asp Pro Ala Thr Met Ser 
    450                 455                 460                 


Leu Leu Gln Arg Ser Leu Asp Pro Glu Lys Thr Leu Gly Leu Val Asp 
465                 470                 475                 480 


Val Leu Tyr Thr Ala Val Leu Asp Leu Asn Arg Trp Arg Ala Gly Arg 
                485                 490                 495     


Glu Gln Ala Leu Pro Cys Ile Gln Ile Gln Leu Gln Arg Glu Ile Cys 
            500                 505                 510         


Asp Phe Gly Asn Gln Ala Asp Leu Pro Ser Gly Asn Gly Asn Lys Ser 
        515                 520                 525             


Ser Gly Gly Leu Gln Lys Thr Phe Ser Lys Leu Thr Ser Arg Phe Thr 
    530                 535                 540                 


Lys Lys Ala Ser Cys Thr Ser Ser Ser Ser Ser Thr Asn Tyr Ser Ile 
545                 550                 555                 560 


Gln Asn Thr Pro Ser Lys Asn Ile Phe Ile Ala Gly Cys Ser Glu Glu 
                565                 570                 575     


Lys Ala Lys Met Pro Gly Asn Ile Asp Thr Arg Leu Gln Ser Ile Leu 
            580                 585                 590         


Asn Ile Gly Asn Phe Pro Arg Thr Thr Asp Pro Ser Gln Ser Ala Gln 
        595                 600                 605             


Asn Ser Ser Asn Thr Val Ala Asn Gly Phe Leu Met Glu Arg Arg Glu 
    610                 615                 620                 


Asn Phe Leu His Gly Asp Asp Gly Lys Asp Glu Lys Gly Met Asn Leu 
625                 630                 635                 640 


Pro Thr Asp Gln Glu Met Gln Glu Val Ile Asp Phe Leu Ser Gly Phe 
                645                 650                 655     


Asn Met Gly Gln Ser His Gln Gly Ser Pro Leu Val Thr Arg His Asn 
            660                 665                 670         


Ser Ala Ala Thr Ala Met Val Thr Glu Gln Lys Ala Gly Ala Met Gln 
        675                 680                 685             


Pro Gln Gln Pro Ser Leu Pro Val Pro Pro Pro Pro Arg Ala Pro Gln 
    690                 695                 700                 


Ala Gly Ala His Thr Pro Leu Thr Pro Gln Pro Gly Leu Ala Pro Gln 
705                 710                 715                 720 


Gln Gln Ser Pro Lys Gln Gln Gln Pro Gln Val Gln Tyr Tyr Gln His 
                725                 730                 735     


Leu Leu Gln Pro Ile Gly Pro Gln Gln Pro Pro Pro Gln Pro Arg Ala 
            740                 745                 750         


Pro Gly Lys Trp Val His Gly Ser Ser Gln Gln Pro Ala Gln Ala Val 
        755                 760                 765             


Gly Ala Gly Leu Ser Pro Leu Gly Gln Trp Pro Gly Ile Ser Asp Leu 
    770                 775                 780                 


Ser Ser Asp Leu Tyr Ser Leu Gly Leu Val Ser Ser Tyr Met Asp Asn 
785                 790                 795                 800 


Val Met Ser Glu Val Leu Gly Gln Lys Pro Gln Gly Pro Arg Asn Asn 
                805                 810                 815     


Thr Trp Pro Asn Arg Asp Gln Ser Asp Gly Val Phe Gly Met Leu Gly 
            820                 825                 830         


Glu Ile Leu Pro Phe Asp Pro Ala Val Gly Ser Asp Pro Glu Phe Ala 
        835                 840                 845             


Arg Tyr Val Ala Gly Val Ser Gln Ala Met Gln Gln Lys Arg Gln Ala 
    850                 855                 860                 


Gln His Gly Arg Arg Pro Gly Asn Pro Arg Gly Asn Trp Pro Pro Met 
865                 870                 875                 880 


Asp Asp Ala His Arg Thr Trp Pro Phe Pro Glu Phe Phe Thr Glu Gly 
                885                 890                 895     


Asp Gly Leu His Gly Gly Trp Ser Gly Ala Gln Gly Asp Ser Ala Ser 
            900                 905                 910         


Ser Ser Asp Glu Thr Ser Ser Ala Asn Gly Asp Ser Leu Phe Ser Met 
        915                 920                 925             


Phe Ser Gly Pro Asp Leu Val Ala Ala Val Lys Gln Arg Arg Lys His 
    930                 935                 940                 


Ser Ser Gly Glu Gln Asp Thr Ser Thr Leu Pro Ser Pro Pro Leu Leu 
945                 950                 955                 960 


Thr Thr Val Glu Asp Val Asn Gln Asp Asn Lys Thr Lys Thr Trp Pro 
                965                 970                 975     


Pro Lys Ala Pro Trp Gln His Pro Ser Pro Leu Pro Ser Thr Leu Pro 
            980                 985                 990         


Ser Pro Ser Ala Pro Leu Tyr Ala  Val Thr Ser Pro Gly  Ser Gln Trp 
        995                 1000                 1005             


Asn Asp  Thr Met Gln Met Leu  Gln Ser Pro Val Trp  Ala Ala Thr 
    1010                 1015                 1020             


Asn Asp  Cys Ser Ala Ala Ala  Phe Ser Tyr Val Gln  Thr Pro Pro 
    1025                 1030                 1035             


Gln Pro  Pro Pro Pro Pro Ala  His Lys Ala Ala Pro  Lys Gly Phe 
    1040                 1045                 1050             


Lys Ala  Phe Pro Gly Lys Gly  Glu Arg Arg Pro Ala  Tyr Leu Pro 
    1055                 1060                 1065             


Gln Tyr  
    1070 


<210>  5838
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0391__Homo_sapiens__NP_001243607

<400>  5838

Met Thr Phe Tyr Leu Phe Gly Ile Arg Ser Phe Pro Lys Leu Trp Lys 
1               5                   10                  15      


Ser Pro Tyr Leu Gly Leu Gly Pro Gly His Ser Tyr Val Ser Leu Phe 
            20                  25                  30          


Leu Ala Asp Arg Cys Gly Ile Arg Asn Gln Gln Arg Leu Phe Ser Leu 
        35                  40                  45              


Lys Thr Met Ser Pro Gln Asn Thr Lys Ala Thr Asn Leu Ile Ala Lys 
    50                  55                  60                  


Ala Arg Tyr Leu Arg Lys Asp Glu Gly Ser Asn Lys Gln Val Tyr Ser 
65                  70                  75                  80  


Val Pro His Phe Phe Leu Ala Gly Ala Ala Lys Glu Arg Ser Gln Met 
                85                  90                  95      


Asn Ser Gln Thr Glu Asp His Ala Leu Ala Pro Val Arg Asn Thr Ile 
            100                 105                 110         


Gln Leu Pro Thr Gln Pro Leu Asn Ser Glu Glu Trp Asp Lys Leu Lys 
        115                 120                 125             


Glu Asp Leu Lys Glu Asn Thr Gly Lys Thr Ser Phe Glu Ser Trp Ile 
    130                 135                 140                 


Ile Ser Gln Met Ala Gly Cys His Ser Ser Ile Asp Val Ala Lys Ser 
145                 150                 155                 160 


Leu Leu Ala Trp Val Ala Ala Lys Asn Asn Gly Ile Val Ser Tyr Asp 
                165                 170                 175     


Leu Leu Val Lys Tyr Leu Tyr Leu Cys Val Phe His Met Gln Thr Ser 
            180                 185                 190         


Glu Val Ile Asp Val Phe Glu Ile Met Lys Ala Arg Tyr Lys Thr Leu 
        195                 200                 205             


Glu Pro Arg Gly Tyr Ser Leu Leu Ile Arg Gly Leu Ile His Ser Asp 
    210                 215                 220                 


Arg Trp Arg Glu Ala Leu Leu Leu Leu Glu Asp Ile Lys Lys Val Ile 
225                 230                 235                 240 


Thr Pro Ser Lys Lys Asn Tyr Asn Asp Cys Ile Gln Gly Ala Leu Leu 
                245                 250                 255     


His Gln Asp Val Asn Thr Ala Trp Asn Leu Tyr Gln Glu Leu Leu Gly 
            260                 265                 270         


His Asp Ile Val Pro Met Leu Glu Thr Leu Lys Ala Phe Phe Asp Phe 
        275                 280                 285             


Gly Lys Asp Ile Lys Asp Asp Asn Tyr Ser Asn Lys Leu Leu Asp Ile 
    290                 295                 300                 


Leu Ser Tyr Leu Arg Asn Asn Gln Leu Tyr Pro Gly Glu Ser Phe Ala 
305                 310                 315                 320 


His Ser Ile Lys Thr Trp Phe Glu Ser Gly Gln Cys Ser Gly Cys Gly 
                325                 330                 335     


Lys Thr Ile Glu Ser Ile Gln Leu Ser Pro Glu Glu Tyr Glu Cys Leu 
            340                 345                 350         


Lys Gly Lys Ile Met Arg Asp Val Ile Asp Gly Gly Asp Gln Tyr Arg 
        355                 360                 365             


Lys Thr Thr Pro Gln Glu Leu Lys Arg Phe Glu Asn Phe Ile Lys Ser 
    370                 375                 380                 


Arg Pro Pro Phe Asp Val Val Ile Asp Gly Leu Asn Val Ala Lys Met 
385                 390                 395                 400 


Phe Pro Lys Val Arg Glu Ser Gln Leu Leu Leu Asn Val Val Ser Gln 
                405                 410                 415     


Leu Ala Lys Arg Asn Leu Arg Leu Leu Val Leu Gly Arg Lys His Met 
            420                 425                 430         


Leu Arg Arg Ser Ser Gln Trp Ser Arg Asp Glu Met Glu Glu Val Gln 
        435                 440                 445             


Lys Gln Ala Ser Cys Phe Phe Ala Asp Asp Ile Ser Glu Asp Asp Pro 
    450                 455                 460                 


Phe Leu Leu Tyr Ala Thr Leu His Ser Gly Asn His Cys Arg Phe Ile 
465                 470                 475                 480 


Thr Arg Asp Leu Met Arg Asp His Lys Ala Cys Leu Pro Asp Ala Lys 
                485                 490                 495     


Thr Gln Arg Leu Phe Phe Lys Trp Gln Gln Gly His Gln Leu Ala Ile 
            500                 505                 510         


Val Asn Arg Phe Pro Gly Ser Lys Leu Thr Phe Gln Arg Ile Leu Ser 
        515                 520                 525             


Tyr Asp Thr Val Val Gln Thr Thr Gly Asp Ser Trp His Ile Pro Tyr 
    530                 535                 540                 


Asp Glu Asp Leu Val Glu Arg Cys Ser Cys Glu Val Pro Thr Lys Trp 
545                 550                 555                 560 


Leu Cys Leu His Gln Lys Thr 
                565         


<210>  5839
<211>  1644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0586__Homo_sapiens__NP_001231118

<400>  5839

Met Phe Trp Cys Gly Thr Cys Phe Val Thr Asn Asn Met Lys Gly Ser 
1               5                   10                  15      


Glu Val Ser Leu Glu Lys Lys Lys Lys Ile Lys Met Pro Val Lys Arg 
            20                  25                  30          


Leu Arg Glu Val Val Ser Gln Asn His Gly Asp His Leu Val Leu Leu 
        35                  40                  45              


Lys Asp Glu Leu Pro Cys Val Pro Pro Ala Leu Ser Ala Asn Lys Arg 
    50                  55                  60                  


Leu Pro Val Gly Thr Gly Thr Ser Leu Asn Gly Thr Ser Arg Gly Ser 
65                  70                  75                  80  


Ser Asp Leu Thr Ser Ala Arg Asn Cys Tyr Gln Pro Leu Leu Glu Asn 
                85                  90                  95      


Pro Met Val Ser Glu Ser Asp Phe Ser Lys Asp Val Ala Val Gln Val 
            100                 105                 110         


Leu Pro Leu Asp Lys Ile Glu Glu Asn Asn Lys Gln Lys Ala Asn Asp 
        115                 120                 125             


Ile Phe Ile Ser Gln Tyr Thr Met Gly Gln Lys Asp Ala Leu Arg Thr 
    130                 135                 140                 


Val Leu Lys Gln Asn Val Ser Leu Cys Leu Thr Gly Trp Ser Asp His 
145                 150                 155                 160 


Ser Gly Val Ile Thr Thr His Cys Ser Leu Tyr Leu Leu Arg Leu Met 
                165                 170                 175     


Arg Ser Ser His Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Ala Gln 
            180                 185                 190         


Ser Met Pro Val Phe Lys Glu Val Lys Val His Leu Leu Glu Asp Ala 
        195                 200                 205             


Gly Ile Glu Lys Asp Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser 
    210                 215                 220                 


Gly Ile Asp Ser Ala Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile 
225                 230                 235                 240 


Ala Thr Ala Ala Pro Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys 
                245                 250                 255     


Val Asn Ser Val Thr Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys 
            260                 265                 270         


His Leu Gln Arg Val Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln 
        275                 280                 285             


Glu Lys Leu His Cys His Asp His Glu Lys Gln Met Asn Val Phe Met 
    290                 295                 300                 


Glu Gln His Ile Arg His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp 
305                 310                 315                 320 


Ile Gln Thr His Phe Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln 
                325                 330                 335     


Pro Val Ser Met Pro Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys 
            340                 345                 350         


Pro Glu His Pro Asn Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr 
        355                 360                 365             


Phe Ala Ser Lys Gln Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe 
    370                 375                 380                 


Asp Lys Gln Lys Ser Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala 
385                 390                 395                 400 


Pro Val Pro Val Ser Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu 
                405                 410                 415     


Leu Glu Glu Lys Glu Asn Met Glu Val Ser Cys His Arg Gly Asn Val 
            420                 425                 430         


Arg Leu Leu Glu Gln Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys 
        435                 440                 445             


Ser Glu Ser Ser Asn Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp 
    450                 455                 460                 


Thr Pro Glu Lys Thr Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr 
465                 470                 475                 480 


Thr Lys Val Thr Met Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly 
                485                 490                 495     


Gln Lys Glu Lys Glu Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu 
            500                 505                 510         


Ser Met Leu Lys Leu Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln 
        515                 520                 525             


Thr Thr Asn Thr Thr Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu 
    530                 535                 540                 


Arg Gly Val Gln Asn Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala 
545                 550                 555                 560 


Ile Ile Arg Ala Lys Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala 
                565                 570                 575     


Leu Ser Thr Asn Arg Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr 
            580                 585                 590         


Val Asp Glu Trp Ile Lys Thr Ile Ser Ala Glu Ile Gln Asp Glu Leu 
        595                 600                 605             


Ser Arg Thr Asp Tyr Glu Gln Lys Arg Phe Asp Gln Lys Asn Gln Arg 
    610                 615                 620                 


Thr Lys Lys Gly Gln Asn Met Thr Lys Asp Ile Arg Thr Asn Thr Gln 
625                 630                 635                 640 


Asp Lys Thr Val Asn Lys Ser Val Ile Pro Arg Lys His Ser Gln Lys 
                645                 650                 655     


Gln Ile Glu Glu His Phe Arg Asn Leu Pro Met Arg Gly Met Pro Ala 
            660                 665                 670         


Ser Ser Leu Gln Lys Glu Arg Lys Glu Gly Leu Leu Lys Ala Thr Thr 
        675                 680                 685             


Val Ile Gln Asp Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val 
    690                 695                 700                 


Tyr Gln Gly His Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe 
705                 710                 715                 720 


Asn Ser Pro Ser Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu 
                725                 730                 735     


Arg Val Lys Gly Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe 
            740                 745                 750         


Tyr Ala Thr Lys Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val 
        755                 760                 765             


Pro Val Leu Pro His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg 
    770                 775                 780                 


Glu Met Pro Thr Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met 
785                 790                 795                 800 


Ala Ile Leu Leu Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro 
                805                 810                 815     


Ala Gly Val Ile Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser 
            820                 825                 830         


Ile Pro Pro Ser Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn 
        835                 840                 845             


Ile Ala Ile Val Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu 
    850                 855                 860                 


Thr Val Gln Val Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser 
865                 870                 875                 880 


Ser Ala Asp Val Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Leu 
                885                 890                 895     


Pro Pro Val Gln Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp 
            900                 905                 910         


Glu Glu Glu Val Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp 
        915                 920                 925             


Val Ile Gln Glu Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro 
    930                 935                 940                 


Ile Leu Glu Phe Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn 
945                 950                 955                 960 


Gly Pro Pro Phe Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp 
                965                 970                 975     


Ile Leu Asp Lys Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu 
            980                 985                 990         


Ile Gln Trp Val Glu Gln Glu Ile  Met Ser Arg Ile Ile  Ser Gly Leu 
        995                 1000                 1005             


Phe Pro  Val Gln Gln Gln Ile  Ala Pro Ser Ile Ser  Val Ser Val 
    1010                 1015                 1020             


Ser Glu  Thr Ser Glu Pro Leu  Thr Ser Asp Ile Val  Glu Gly Thr 
    1025                 1030                 1035             


Ser Ser  Gly Ala Leu Gln Leu  Phe Val Asp Ala Gly  Val Pro Val 
    1040                 1045                 1050             


Asn Ser  Asn Val Ile Lys His  Phe Val Asn Glu Ala  Leu Ala Glu 
    1055                 1060                 1065             


Thr Ile  Ala Val Met Leu Gly  Asp Arg Glu Ala Lys  Lys Gln Gly 
    1070                 1075                 1080             


Pro Val  Ala Thr Gly Val Ser  Gly Asp Ala Ser Thr  Asn Glu Thr 
    1085                 1090                 1095             


Tyr Leu  Pro Ala Arg Val Cys  Thr Pro Leu Pro Thr  Pro Gln Pro 
    1100                 1105                 1110             


Thr Pro  Pro Cys Ser Pro Ser  Ser Pro Ala Lys Glu  Cys Val Leu 
    1115                 1120                 1125             


Val Lys  Thr Pro Asp Ser Ser  Pro Cys Asp Ser Asp  His Asp Met 
    1130                 1135                 1140             


Ala Phe  Pro Val Lys Glu Ile  Cys Ala Glu Lys Gly  Asp Asp Met 
    1145                 1150                 1155             


Pro Ala  Ile Met Leu Val Asn  Thr Pro Thr Val Thr  Pro Thr Thr 
    1160                 1165                 1170             


Thr Pro  Pro Pro Ala Ala Ala  Val Phe Thr Pro Thr  Leu Ser Asp 
    1175                 1180                 1185             


Ile Ser  Ile Asp Lys Leu Lys  Val Ser Ser Pro Glu  Leu Pro Lys 
    1190                 1195                 1200             


Pro Trp  Gly Asp Gly Asp Leu  Pro Leu Glu Glu Glu  Asn Pro Asn 
    1205                 1210                 1215             


Ser Pro  Gln Glu Glu Leu His  Pro Arg Ala Ile Val  Met Ser Val 
    1220                 1225                 1230             


Ala Lys  Asp Glu Glu Pro Glu  Ser Met Asp Phe Pro  Ala Gln Pro 
    1235                 1240                 1245             


Pro Pro  Pro Glu Pro Val Pro  Phe Met Pro Phe Pro  Ala Gly Thr 
    1250                 1255                 1260             


Lys Ala  Pro Ser Pro Ser Gln  Met Pro Gly Ser Asp  Ser Ser Thr 
    1265                 1270                 1275             


Leu Glu  Ser Thr Leu Ser Val  Thr Val Thr Glu Thr  Glu Thr Leu 
    1280                 1285                 1290             


Asp Lys  Pro Ile Ser Glu Gly  Glu Ile Leu Phe Ser  Cys Gly Gln 
    1295                 1300                 1305             


Lys Leu  Ala Pro Lys Ile Leu  Glu Asp Ile Gly Leu  Tyr Leu Thr 
    1310                 1315                 1320             


Asn Leu  Asn Asp Ser Leu Ser  Ser Thr Leu His Asp  Ala Val Glu 
    1325                 1330                 1335             


Met Glu  Asp Asp Pro Pro Ser  Glu Gly Gln Val Ile  Arg Met Ser 
    1340                 1345                 1350             


His Lys  Lys Phe His Ala Asp  Ala Ile Leu Ser Phe  Ala Lys Gln 
    1355                 1360                 1365             


Asn Gln  Glu Ser Ala Val Ser  Gln Gln Ala Val Tyr  His Ser Glu 
    1370                 1375                 1380             


Asp Leu  Glu Asn Ser Val Gly  Glu Leu Ser Glu Gly  Gln Arg Pro 
    1385                 1390                 1395             


Gln Leu  Thr Ala Ala Ala Glu  Asn Ile Leu Met Gly  His Ser Leu 
    1400                 1405                 1410             


Tyr Met  Gln Pro Pro Val Thr  Asn Thr Gln Ser Leu  Asp Gln Gln 
    1415                 1420                 1425             


Cys Asp  Pro Lys Pro Leu Ser  Arg Gln Phe Asp Thr  Val Ser Gly 
    1430                 1435                 1440             


Ser Ile  Tyr Glu Asp Ser Cys  Ala Ser His Gly Pro  Met Ser Leu 
    1445                 1450                 1455             


Gly Glu  Leu Glu Leu Glu Pro  Asn Ser Lys Leu Val  Leu Pro Thr 
    1460                 1465                 1470             


Thr Leu  Leu Thr Ala Gln Glu  Asn Asp Val Asn Leu  Pro Val Ala 
    1475                 1480                 1485             


Ala Glu  Asp Phe Ser Gln Tyr  Gln Leu Lys Gln Asn  Gln Asp Val 
    1490                 1495                 1500             


Lys Gln  Val Glu His Lys Pro  Ser Gln Ser Tyr Leu  Arg Val Arg 
    1505                 1510                 1515             


Asn Lys  Ser Asp Ile Ala Pro  Ser Gln Gln Gln Val  Ser Pro Gly 
    1520                 1525                 1530             


Asp Met  Asp Arg Thr Gln Ile  Glu Leu Asn Pro Tyr  Leu Thr Cys 
    1535                 1540                 1545             


Val Phe  Ser Gly Leu Gly Val  His Val Lys Lys Val  Ser Cys Ile 
    1550                 1555                 1560             


Gly Lys  Leu Gly Leu Trp Arg  Phe Val Ile Gln Ile  Ile Ser Ser 
    1565                 1570                 1575             


Pro Arg  Trp Glu Ser Ser Ala  Thr Leu Arg Phe Thr  Asp Ala Pro 
    1580                 1585                 1590             


Cys Gln  Asp Val Ser Asp Ala  Ala Val Ser Glu Pro  Arg Gly Leu 
    1595                 1600                 1605             


Leu Ser  Val Ser Glu Ser Gln  His Asn Ala Gly Gly  His Gly Val 
    1610                 1615                 1620             


Phe Gly  Gly Arg Tyr Leu Leu  Asn Gly Lys Arg Gln  Pro Ala Gln 
    1625                 1630                 1635             


Cys Leu  Cys His Trp Phe 
    1640                 


<210>  5840
<211>  1275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0825__Homo_sapiens__NP_001139150

<400>  5840

Met Asp Trp Asp Asp Glu Tyr Ser His Asn Ser Phe Asp Leu His Cys 
1               5                   10                  15      


Leu Leu Asn Ser Phe Pro Gly Asp Leu Glu Phe Glu Gln Ile Phe Ser 
            20                  25                  30          


Asp Ile Asp Glu Lys Ile Glu Gln Asn Ala Ala Ser Ile Lys His Cys 
        35                  40                  45              


Ile Lys Glu Ile Gln Ser Glu Ile Asn Lys Gln Cys Pro Gly Val Gln 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asp Cys Phe Glu Trp Leu Thr Asn Tyr Asn Tyr 
65                  70                  75                  80  


Ser Thr Ser Glu Ser Ser Phe Ile Ser His Gly Asp Leu Ile Lys Phe 
                85                  90                  95      


Phe Lys Thr Leu Gln Asp Leu Leu Lys Asn Glu Gln Asn Gln Glu Glu 
            100                 105                 110         


Met Thr Leu Asp Leu Leu Trp Asp Leu Ser Cys His Ser Ser Val Ser 
        115                 120                 125             


Phe Pro Ser Thr Leu Ser Gly Thr Ser Phe His Phe Leu Ser Arg Thr 
    130                 135                 140                 


Ser Leu His Ser Val Glu Asp Asn Ser Ser Met Asp Val Lys Ser Met 
145                 150                 155                 160 


Trp Asp Asp Ile Arg Leu His Leu Arg Arg Phe Leu Val Ser Lys Leu 
                165                 170                 175     


Gln Ser His Asn Glu Ile Asn Asn Ser Gln Gln Lys Ile Leu Leu Lys 
            180                 185                 190         


Lys Gln Cys Leu Gln Gln Leu Leu Phe Leu Tyr Pro Glu Ser Glu Val 
        195                 200                 205             


Ile Ile Lys Tyr Gln Asn Ile Gln Asn Lys Leu Leu Ala Asn Leu Leu 
    210                 215                 220                 


Trp Asn Cys Phe Pro Ser Tyr Asn Arg Asp Ser Asn Leu Asp Val Ile 
225                 230                 235                 240 


Ala His Gly Tyr Gln Ser Thr Met Leu Lys Leu Tyr Ser Val Ile Lys 
                245                 250                 255     


Glu Asp Phe Asn Thr Leu Cys Glu Ile Leu Ala Pro Ser Ser Met Val 
            260                 265                 270         


Lys Phe Ile Lys Glu Thr Tyr Leu Asp Thr Val Thr Glu Glu Met Ala 
        275                 280                 285             


Lys Phe Leu Glu Asn Phe Cys Glu Leu Gln Phe Arg Glu Asn Ala Val 
    290                 295                 300                 


Arg Val Val Lys Thr Ser Lys Ser Ser Ser Lys His Arg Gly Ala Val 
305                 310                 315                 320 


His Ala Leu Val Thr Thr Glu Cys Pro Gln Lys Gly Arg Asn Phe Ser 
                325                 330                 335     


Leu Pro Leu Asp Lys Val Glu Phe Leu Ser Gln Leu Ile Lys Ser Phe 
            340                 345                 350         


Met Lys Leu Glu Lys Gly Val Gln Glu Leu Phe Asp Glu Ile Leu Leu 
        355                 360                 365             


Ser Leu Lys Ile Thr Arg Asp Thr Ser Gly Ile Leu Glu Lys Ser Asp 
    370                 375                 380                 


Arg Glu Val Val Met Glu Lys Pro Arg Ala Asn Glu Thr Asn Ile Pro 
385                 390                 395                 400 


Ser Glu Gln Ser Leu Pro Gly Lys Glu Ala Thr Leu Leu Asp Phe Gly 
                405                 410                 415     


Trp Arg Ser Ala Phe Lys Glu Val Ser Leu Pro Met Ala His Cys Val 
            420                 425                 430         


Val Thr Ala Ile Glu Gly Phe Ser Thr Lys Ile Leu Gln Gln Glu Gln 
        435                 440                 445             


Asn Glu Arg Ser Ser Ala Val Ser Tyr Ala Met Asn Leu Val Asn Val 
    450                 455                 460                 


Gln Gln Val Trp Gln Asp Ser His Met Phe Pro Glu Glu Glu Gln Pro 
465                 470                 475                 480 


Lys Lys Ile Gly Lys Phe Cys Ser Asp Ile Met Glu Lys Leu Asp Thr 
                485                 490                 495     


Met Leu Pro Leu Ala Leu Ala Cys Arg Asp Asp Ser Phe Gln Glu Ile 
            500                 505                 510         


Arg Ala Asn Leu Val Glu Ala Cys Cys Lys Val Ala Thr Ala Val Leu 
        515                 520                 525             


Gln Arg Leu Gln Glu Arg Ala Lys Glu Val Pro Ser Lys Ala Pro Leu 
    530                 535                 540                 


Lys Asn Leu His Thr Tyr Leu Ser Thr Ala Val Tyr Val Phe Gln His 
545                 550                 555                 560 


Phe Lys Arg Tyr Asp Asn Leu Met Lys Glu Met Thr Lys Lys Pro Ile 
                565                 570                 575     


Phe Leu Val Leu Val Gln Arg Tyr Gln Glu Phe Ile Asn Thr Leu Gln 
            580                 585                 590         


Phe Gln Val Thr Asn Tyr Cys Val Arg Val Cys Ala Thr Ser Ile Leu 
        595                 600                 605             


Gln Asp Ala Glu Ser His His Trp Asp Asp Tyr Lys Ala Phe Tyr Glu 
    610                 615                 620                 


Gly Glu Arg Cys Ser Phe Ser Ile Gln Met Trp His Tyr Phe Cys Trp 
625                 630                 635                 640 


Ser Leu His Tyr Asp Leu Trp Thr Ile Leu Pro Pro Lys Leu Ala Gln 
                645                 650                 655     


Glu Ile Leu Val Glu Val Leu Glu Lys Ser Leu Ser Leu Leu Ala Ser 
            660                 665                 670         


Arg Tyr Ala Arg Ala His Pro Ser Arg Lys Arg Thr Pro Gln Leu Arg 
        675                 680                 685             


Leu Asp Val Thr Thr Ile Leu Ile Cys Thr Glu Asn Met Leu Trp Ser 
    690                 695                 700                 


Val Cys Thr Ser Val Gln Lys Leu Leu Asn Pro His Gln His Thr Asp 
705                 710                 715                 720 


Asp Lys Ile Phe Lys Ile His Thr His Cys Asn Asn Leu Phe Thr Thr 
                725                 730                 735     


Leu Val Ile Leu Thr Ser Pro Leu Thr Glu Leu Tyr Lys Thr Phe Gln 
            740                 745                 750         


His Gly Leu Asp Glu Ser Ala Ser Asp Ser Leu Lys Ser Phe Phe Lys 
        755                 760                 765             


Gln Pro Leu Tyr Trp Val Ser Cys Ile Ser His Phe Tyr Pro Ser Leu 
    770                 775                 780                 


Leu Arg Thr Pro Ser Ala Gly Gly Leu Lys Ala Glu Gly Gln Leu Lys 
785                 790                 795                 800 


Leu Leu Leu Ser Gln Pro Arg Cys Asn Trp Asn Leu Leu Leu Glu Thr 
                805                 810                 815     


Leu Leu His His Asp Gly Leu Leu Leu Arg Ile Leu Leu Lys Ser Ser 
            820                 825                 830         


Lys Gln Val Ser Asp Thr Glu Asn Asn Leu Asn Gln Gly Pro Ser Leu 
        835                 840                 845             


Met Glu Ala Ile Phe Lys Ile Leu Tyr His Cys Ser Phe Ser Pro Gln 
    850                 855                 860                 


Thr Phe Ala Asn Val Phe Val Ser Tyr Met Glu Glu Glu Gln Leu Trp 
865                 870                 875                 880 


Asp Phe Leu Tyr Asn Ile Pro Val Ser Thr Cys Val Glu Tyr Glu Leu 
                885                 890                 895     


Glu Val Ile Arg Cys Leu Arg Leu Ala Leu Thr Asp Ala Ile Lys Asp 
            900                 905                 910         


Thr Val Gln Gln Ile Val Ser Val Met Ser Ser Arg Arg Asn Cys Glu 
        915                 920                 925             


Thr Asn Leu Asn Lys His Ile Val Pro Asp Cys Leu Leu Glu Ser Met 
    930                 935                 940                 


Pro Lys Glu Trp Asn Tyr Ser Pro Lys Glu Thr Asn Arg Lys Glu Ser 
945                 950                 955                 960 


Cys Lys Ser Phe Thr Arg Leu Thr Ala Gln Ala Val Ser Ile Val Ile 
                965                 970                 975     


Ser Lys Leu Pro Thr Val Ile Ala Cys Leu Pro Pro Pro Val Lys Tyr 
            980                 985                 990         


Phe Phe Phe Leu Ser Glu Arg Lys  Met Ser Lys Lys Phe  Val Glu Leu 
        995                 1000                 1005             


Lys Lys  Ala Gly Leu Leu Val  Trp Asn Leu Ile Val  Ile Ile Cys 
    1010                 1015                 1020             


Arg Ile  Phe Glu Asp Gly Asn  Thr Val Glu Leu Leu  Thr Gly Ala 
    1025                 1030                 1035             


Ser Leu  Asp Arg Trp Ser Lys  Glu Lys Leu Gly Leu  Ile Cys Met 
    1040                 1045                 1050             


Cys Leu  Lys Ser Ile Met Gly  Asp Gln Thr Ser Ile  His Asn Gln 
    1055                 1060                 1065             


Met Ile  Gln Lys Val Ile Gln  Ser Ile Glu Gln Gln  Lys Pro Asn 
    1070                 1075                 1080             


Trp Ile  Glu Arg Gln Leu Leu  Lys Ala Arg Lys Leu  Ser Thr Glu 
    1085                 1090                 1095             


Cys Ala  Phe Met Thr Ile Glu  Lys Ser Thr Ala Leu  Gln Glu Gly 
    1100                 1105                 1110             


Asp Val  Ala Leu Glu Leu Thr  Glu Gln Lys Ile Asn  Thr Met Val 
    1115                 1120                 1125             


Leu Asp  Leu Cys His Lys Pro  Gly Gly Arg Glu Tyr  Leu Arg Gln 
    1130                 1135                 1140             


Ile Tyr  His Ile Met Gln Leu  Asn Glu Glu Tyr Leu  Lys Glu Gln 
    1145                 1150                 1155             


Leu Phe  Ser Met Asn Ser Ser  Glu Glu Lys Pro Leu  Pro Ile Arg 
    1160                 1165                 1170             


Pro Leu  Lys Thr Thr Leu Arg  Ser Ile Glu Asp Gln  Pro Ser Ala 
    1175                 1180                 1185             


Phe Asn  Pro Phe His Val Tyr  Lys Ala Phe Ser Glu  Asn Met Leu 
    1190                 1195                 1200             


Asp Gln  Val Ser Ile Thr Lys  Trp Asn Trp Asn Trp  Ala Lys Leu 
    1205                 1210                 1215             


Leu Pro  Asn Tyr Leu Arg Leu  Asp Lys Met Thr Phe  Ser Val Leu 
    1220                 1225                 1230             


Leu Lys  Asn Arg Trp Glu Met  Lys Lys Asp Glu Thr  Leu Glu Glu 
    1235                 1240                 1245             


Glu Glu  Lys Ala Ile Leu Glu  His Leu Lys Gln Ile  Cys Thr Pro 
    1250                 1255                 1260             


Gln Asn  Ser Ser Ala Ser Asp  Asn Ile Glu Glu Gln  
    1265                 1270                 1275 


<210>  5841
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0907__Homo_sapiens__NP_055764

<400>  5841

Met Ser Ala Gly Ser Ala Thr His Pro Gly Ala Gly Gly Arg Arg Ser 
1               5                   10                  15      


Lys Trp Asp Gln Pro Ala Pro Ala Pro Leu Leu Phe Leu Pro Pro Ala 
            20                  25                  30          


Ala Pro Gly Gly Glu Val Thr Ser Ser Gly Gly Ser Pro Gly Gly Thr 
        35                  40                  45              


Thr Ala Ala Pro Ser Gly Ala Leu Asp Ala Ala Ala Ala Val Ala Ala 
    50                  55                  60                  


Lys Ile Asn Ala Met Leu Met Ala Lys Gly Lys Leu Lys Pro Thr Gln 
65                  70                  75                  80  


Asn Ala Ser Glu Lys Leu Gln Ala Pro Gly Lys Gly Leu Thr Ser Asn 
                85                  90                  95      


Lys Ser Lys Asp Asp Leu Val Val Ala Glu Val Glu Ile Asn Asp Val 
            100                 105                 110         


Pro Leu Thr Cys Arg Asn Leu Leu Thr Arg Gly Gln Thr Gln Asp Glu 
        115                 120                 125             


Ile Ser Arg Leu Ser Gly Ala Ala Val Ser Thr Arg Gly Arg Phe Met 
    130                 135                 140                 


Thr Thr Glu Glu Lys Ala Lys Val Gly Pro Gly Asp Arg Pro Leu Tyr 
145                 150                 155                 160 


Leu His Val Gln Gly Gln Thr Arg Glu Leu Val Asp Arg Ala Val Asn 
                165                 170                 175     


Arg Ile Lys Glu Ile Ile Thr Asn Gly Val Val Lys Ala Ala Thr Gly 
            180                 185                 190         


Thr Ser Pro Thr Phe Asn Gly Ala Thr Val Thr Val Tyr His Gln Pro 
        195                 200                 205             


Ala Pro Ile Ala Gln Leu Ser Pro Ala Val Ser Gln Lys Pro Pro Phe 
    210                 215                 220                 


Gln Ser Gly Met His Tyr Val Gln Asp Lys Leu Phe Val Gly Leu Glu 
225                 230                 235                 240 


His Ala Val Pro Thr Phe Asn Val Lys Glu Lys Val Glu Gly Pro Gly 
                245                 250                 255     


Cys Ser Tyr Leu Gln His Ile Gln Ile Glu Thr Gly Ala Lys Val Phe 
            260                 265                 270         


Leu Arg Gly Lys Gly Ser Gly Cys Ile Glu Pro Ala Ser Gly Arg Glu 
        275                 280                 285             


Ala Phe Glu Pro Met Tyr Ile Tyr Ile Ser His Pro Lys Pro Glu Gly 
    290                 295                 300                 


Leu Ala Ala Ala Lys Lys Leu Cys Glu Asn Leu Leu Gln Thr Val His 
305                 310                 315                 320 


Ala Glu Tyr Ser Arg Phe Val Asn Gln Ile Asn Thr Ala Val Pro Leu 
                325                 330                 335     


Pro Gly Tyr Thr Gln Pro Ser Ala Ile Ser Ser Val Pro Pro Gln Pro 
            340                 345                 350         


Pro Tyr Tyr Pro Ser Asn Gly Tyr Gln Ser Gly Tyr Pro Val Val Pro 
        355                 360                 365             


Pro Pro Gln Gln Pro Val Gln Pro Pro Tyr Gly Val Pro Ser Ile Val 
    370                 375                 380                 


Pro Pro Ala Val Ser Leu Ala Pro Gly Val Leu Pro Ala Leu Pro Thr 
385                 390                 395                 400 


Gly Val Pro Pro Val Pro Thr Gln Tyr Pro Ile Thr Gln Val Gln Pro 
                405                 410                 415     


Pro Ala Ser Thr Gly Gln Ser Pro Met Gly Gly Pro Phe Ile Pro Ala 
            420                 425                 430         


Ala Pro Val Lys Thr Ala Leu Pro Ala Gly Pro Gln Pro Gln Pro Gln 
        435                 440                 445             


Pro Gln Pro Pro Leu Pro Ser Gln Pro Gln Ala Gln Lys Arg Arg Phe 
    450                 455                 460                 


Thr Glu Glu Leu Pro Asp Glu Arg Glu Ser Gly Leu Leu Gly Tyr Gln 
465                 470                 475                 480 


His Gly Pro Ile His Met Thr Asn Leu Gly Thr Gly Phe Ser Ser Gln 
                485                 490                 495     


Asn Glu Ile Glu Gly Ala Gly Ser Lys Pro Ala Ser Ser Ser Gly Lys 
            500                 505                 510         


Glu Arg Glu Arg Asp Arg Gln Leu Met Pro Pro Pro Ala Phe Pro Val 
        515                 520                 525             


Thr Gly Ile Lys Thr Glu Ser Asp Glu Arg Asn Gly Ser Gly Thr Leu 
    530                 535                 540                 


Thr Gly Ser His Asp Tyr Pro Ala Lys Lys Met Lys Thr Thr Glu Lys 
545                 550                 555                 560 


Gly Phe Gly Leu Val Ala Tyr Ala Ala Asp Ser Ser Asp Glu Glu Glu 
                565                 570                 575     


Glu His Gly Gly His Lys Asn Ala Ser Ser Phe Pro Gln Gly Trp Ser 
            580                 585                 590         


Leu Gly Tyr Gln Tyr Pro Ser Ser Gln Pro Arg Ala Lys Gln Gln Met 
        595                 600                 605             


Pro Phe Trp Met Ala Pro 
    610                 


<210>  5842
<211>  1610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA0922__Homo_sapiens__NP_001124479

<400>  5842

Met Ala Gly Leu Arg Arg Pro Gln Pro Gly Cys Tyr Cys Arg Thr Ala 
1               5                   10                  15      


Ala Ala Val Asn Leu Leu Leu Gly Val Phe Gln Val Leu Leu Pro Cys 
            20                  25                  30          


Cys Arg Pro Gly Gly Ala Gln Gly Gln Ala Ile Glu Pro Leu Pro Asn 
        35                  40                  45              


Val Val Glu Leu Trp Gln Ala Glu Glu Gly Glu Leu Leu Leu Pro Thr 
    50                  55                  60                  


Gln Gly Asp Ser Glu Glu Gly Leu Glu Glu Pro Ser Gln Glu Gln Ser 
65                  70                  75                  80  


Phe Ser Asp Lys Leu Phe Ser Gly Lys Gly Leu His Phe Gln Pro Ser 
                85                  90                  95      


Val Leu Asp Phe Gly Ile Gln Phe Leu Gly His Pro Val Ala Lys Ile 
            100                 105                 110         


Leu His Ala Tyr Asn Pro Ser Arg Asp Ser Glu Val Val Val Asn Ser 
        115                 120                 125             


Val Phe Ala Ala Ala Gly His Phe His Val Pro Pro Val Pro Cys Arg 
    130                 135                 140                 


Val Ile Pro Ala Met Gly Lys Thr Ser Phe Arg Ile Ile Phe Leu Pro 
145                 150                 155                 160 


Thr Glu Glu Gly Ser Ile Glu Ser Ser Leu Phe Ile Asn Thr Ser Ser 
                165                 170                 175     


Tyr Gly Val Leu Ser Tyr His Val Ser Gly Ile Gly Thr Arg Arg Ile 
            180                 185                 190         


Ser Thr Glu Gly Ser Ala Lys Gln Leu Pro Asn Ala Tyr Phe Leu Leu 
        195                 200                 205             


Pro Lys Val Gln Ser Ile Gln Leu Ser Gln Met Gln Ala Glu Thr Thr 
    210                 215                 220                 


Asn Thr Ser Leu Leu Gln Val Gln Leu Glu Cys Ser Leu His Asn Lys 
225                 230                 235                 240 


Val Cys Gln Gln Leu Lys Gly Cys Tyr Leu Glu Ser Asp Asp Val Leu 
                245                 250                 255     


Arg Leu Gln Met Ser Ile Met Val Thr Met Glu Asn Phe Ser Lys Glu 
            260                 265                 270         


Phe Glu Glu Asn Thr Gln His Leu Leu Asp His Leu Ser Ile Val Tyr 
        275                 280                 285             


Val Ala Thr Asp Glu Ser Glu Thr Ser Asp Asp Ser Ala Val Asn Met 
    290                 295                 300                 


Tyr Ile Leu His Ser Gly Asn Ser Leu Ile Trp Ile Gln Asp Ile Arg 
305                 310                 315                 320 


His Phe Ser Gln Arg Asp Ala Leu Ser Leu Gln Phe Glu Pro Val Leu 
                325                 330                 335     


Leu Pro Thr Ser Thr Thr Asn Phe Thr Lys Ile Ala Ser Phe Thr Cys 
            340                 345                 350         


Lys Ala Ala Thr Ser Cys Asp Ser Gly Ile Ile Glu Asp Val Lys Lys 
        355                 360                 365             


Thr Thr His Thr Pro Thr Leu Lys Ala Cys Leu Phe Ser Ser Val Ala 
    370                 375                 380                 


Gln Gly Tyr Phe Arg Met Asp Ser Ser Ala Thr Gln Phe His Ile Glu 
385                 390                 395                 400 


Thr His Glu Asn Thr Ser Gly Leu Trp Ser Ile Trp Tyr Arg Asn His 
                405                 410                 415     


Phe Asp Arg Ser Val Val Leu Asn Asp Val Phe Leu Ser Lys Glu Thr 
            420                 425                 430         


Lys His Met Leu Lys Ile Leu Asn Phe Thr Gly Pro Leu Phe Leu Pro 
        435                 440                 445             


Pro Gly Cys Trp Asn Ile Phe Ser Leu Lys Leu Ala Val Lys Asp Ile 
    450                 455                 460                 


Ala Ile Asn Leu Phe Thr Asn Val Phe Leu Thr Thr Asn Ile Gly Ala 
465                 470                 475                 480 


Ile Phe Ala Ile Pro Leu Gln Ile Tyr Ser Ala Pro Thr Lys Glu Gly 
                485                 490                 495     


Ser Leu Gly Phe Glu Val Ile Ala His Cys Gly Met His Tyr Phe Met 
            500                 505                 510         


Gly Lys Ser Lys Ala Gly Asn Pro Asn Trp Asn Gly Ser Leu Ser Leu 
        515                 520                 525             


Asp Gln Ser Thr Trp Asn Val Asp Ser Glu Leu Ala Asn Lys Leu Tyr 
    530                 535                 540                 


Glu Arg Trp Lys Lys Tyr Lys Asn Gly Asp Val Cys Lys Arg Asn Val 
545                 550                 555                 560 


Leu Gly Thr Thr Arg Phe Ala His Leu Lys Lys Ser Lys Glu Ser Glu 
                565                 570                 575     


Ser Phe Val Phe Phe Leu Pro Arg Leu Ile Ala Glu Pro Gly Leu Met 
            580                 585                 590         


Leu Asn Phe Ser Ala Thr Ala Leu Arg Ser Arg Met Ile Lys Tyr Phe 
        595                 600                 605             


Val Val Gln Asn Pro Ser Ser Trp Pro Val Ser Leu Gln Leu Leu Pro 
    610                 615                 620                 


Leu Ser Leu Tyr Pro Lys Pro Glu Ala Leu Val His Leu Leu His Arg 
625                 630                 635                 640 


Trp Phe Gly Thr Asp Met Gln Met Ile Asn Phe Thr Thr Gly Glu Phe 
                645                 650                 655     


Gln Leu Thr Glu Ala Cys Pro Tyr Leu Gly Thr His Ser Glu Glu Ser 
            660                 665                 670         


Arg Phe Gly Ile Leu His Leu His Leu Gln Pro Leu Glu Met Lys Arg 
        675                 680                 685             


Val Gly Val Val Phe Thr Pro Ala Asp Tyr Gly Lys Val Thr Ser Leu 
    690                 695                 700                 


Ile Leu Ile Arg Asn Asn Leu Thr Val Ile Asp Met Ile Gly Val Glu 
705                 710                 715                 720 


Gly Phe Gly Ala Arg Glu Leu Leu Lys Val Gly Gly Arg Leu Pro Gly 
                725                 730                 735     


Ala Gly Gly Ser Leu Arg Phe Lys Val Pro Glu Ser Thr Leu Met Asp 
            740                 745                 750         


Cys Arg Arg Gln Leu Lys Asp Ser Lys Gln Ile Leu Ser Ile Thr Lys 
        755                 760                 765             


Asn Phe Lys Val Glu Asn Ile Gly Pro Leu Pro Ile Thr Val Ser Ser 
    770                 775                 780                 


Leu Lys Ile Asn Gly Tyr Asn Cys Gln Gly Tyr Gly Phe Glu Val Leu 
785                 790                 795                 800 


Asp Cys His Gln Phe Ser Leu Asp Pro Asn Thr Ser Arg Asp Ile Ser 
                805                 810                 815     


Ile Val Phe Thr Pro Asp Phe Thr Ser Ser Trp Val Ile Arg Asp Leu 
            820                 825                 830         


Ser Leu Val Thr Ala Ala Asp Leu Glu Phe Arg Phe Thr Leu Asn Val 
        835                 840                 845             


Thr Leu Pro His His Leu Leu Pro Leu Cys Ala Asp Val Val Pro Gly 
    850                 855                 860                 


Pro Ser Trp Glu Glu Ser Phe Trp Arg Leu Thr Val Phe Phe Val Ser 
865                 870                 875                 880 


Leu Ser Leu Leu Gly Val Ile Leu Ile Ala Phe Gln Gln Ala Gln Tyr 
                885                 890                 895     


Ile Leu Met Glu Phe Met Lys Thr Arg Gln Arg Gln Asn Ala Ser Ser 
            900                 905                 910         


Ser Ser Gln Gln Asn Asn Gly Pro Met Asp Val Ile Ser Pro His Ser 
        915                 920                 925             


Tyr Lys Ser Asn Cys Lys Asn Phe Leu Asp Thr Tyr Gly Pro Ser Asp 
    930                 935                 940                 


Lys Gly Arg Gly Lys Asn Cys Leu Pro Val Asn Thr Pro Gln Ser Arg 
945                 950                 955                 960 


Ile Gln Asn Ala Ala Lys Arg Ser Pro Ala Thr Tyr Gly His Ser Gln 
                965                 970                 975     


Lys Lys His Lys Cys Ser Val Tyr Tyr Ser Lys His Lys Thr Ser Thr 
            980                 985                 990         


Ala Ala Ala Ser Ser Thr Ser Thr  Thr Thr Glu Glu Lys  Gln Thr Ser 
        995                 1000                 1005             


Pro Leu  Gly Ser Ser Leu Pro  Ala Ala Lys Glu Asp  Ile Cys Thr 
    1010                 1015                 1020             


Asp Ala  Met Arg Glu Asn Trp  Ile Ser Leu Arg Tyr  Ala Ser Gly 
    1025                 1030                 1035             


Ile Asn  Val Asn Leu Gln Lys  Asn Leu Thr Leu Pro  Lys Asn Leu 
    1040                 1045                 1050             


Leu Asn  Lys Glu Glu Asn Thr  Leu Lys Asn Thr Ile  Val Phe Ser 
    1055                 1060                 1065             


Asn Pro  Ser Ser Glu Cys Ser  Met Lys Glu Gly Ile  Gln Thr Cys 
    1070                 1075                 1080             


Met Phe  Pro Lys Glu Thr Asp  Ile Lys Thr Ser Glu  Asn Thr Ala 
    1085                 1090                 1095             


Glu Phe  Lys Glu Arg Glu Leu  Cys Pro Leu Lys Thr  Ser Lys Lys 
    1100                 1105                 1110             


Leu Pro  Glu Asn His Leu Pro  Arg Asn Ser Pro Gln  Tyr His Gln 
    1115                 1120                 1125             


Pro Asp  Leu Pro Glu Ile Ser  Arg Lys Asn Asn Gly  Asn Asn Gln 
    1130                 1135                 1140             


Gln Val  Pro Val Lys Asn Glu  Val Asp His Cys Glu  Asn Leu Lys 
    1145                 1150                 1155             


Lys Val  Asp Thr Lys Pro Ser  Ser Glu Lys Lys Ile  His Lys Thr 
    1160                 1165                 1170             


Ser Arg  Glu Asp Met Phe Ser  Glu Lys Gln Asp Ile  Pro Phe Val 
    1175                 1180                 1185             


Glu Gln  Glu Asp Pro Tyr Arg  Lys Lys Lys Leu Gln  Glu Lys Arg 
    1190                 1195                 1200             


Glu Gly  Asn Leu Gln Asn Leu  Asn Trp Ser Lys Ser  Arg Thr Cys 
    1205                 1210                 1215             


Arg Lys  Asn Lys Lys Arg Gly  Val Ala Pro Val Ser  Arg Pro Pro 
    1220                 1225                 1230             


Glu Gln  Ser Asp Leu Lys Leu  Val Cys Ser Asp Phe  Glu Arg Ser 
    1235                 1240                 1245             


Glu Leu  Ser Ser Asp Ile Asn  Val Arg Ser Trp Cys  Ile Gln Glu 
    1250                 1255                 1260             


Ser Thr  Arg Glu Val Cys Lys  Ala Asp Ala Glu Ile  Ala Ser Ser 
    1265                 1270                 1275             


Leu Pro  Ala Ala Gln Arg Glu  Ala Glu Gly Tyr Tyr  Gln Lys Pro 
    1280                 1285                 1290             


Glu Lys  Lys Cys Val Asp Lys  Phe Cys Ser Asp Ser  Ser Ser Asp 
    1295                 1300                 1305             


Cys Gly  Ser Ser Ser Gly Ser  Val Arg Ala Ser Arg  Gly Ser Trp 
    1310                 1315                 1320             


Gly Ser  Trp Ser Ser Thr Ser  Ser Ser Asp Gly Asp  Lys Lys Pro 
    1325                 1330                 1335             


Met Val  Asp Ala Gln His Phe  Leu Pro Ala Gly Asp  Ser Val Ser 
    1340                 1345                 1350             


Gln Asn  Asp Phe Pro Ser Glu  Ala Pro Ile Ser Leu  Asn Leu Ser 
    1355                 1360                 1365             


His Asn  Ile Cys Asn Pro Met  Thr Val Asn Ser Leu  Pro Gln Tyr 
    1370                 1375                 1380             


Ala Glu  Pro Ser Cys Pro Ser  Leu Pro Ala Gly Pro  Thr Gly Val 
    1385                 1390                 1395             


Glu Glu  Asp Lys Gly Leu Tyr  Ser Pro Gly Asp Leu  Trp Pro Thr 
    1400                 1405                 1410             


Pro Pro  Val Cys Val Thr Ser  Ser Leu Asn Cys Thr  Leu Glu Asn 
    1415                 1420                 1425             


Gly Val  Pro Cys Val Ile Gln  Glu Ser Ala Pro Val  His Asn Ser 
    1430                 1435                 1440             


Phe Ile  Asp Trp Ser Ala Thr  Cys Glu Gly Gln Phe  Ser Ser Ala 
    1445                 1450                 1455             


Tyr Cys  Pro Leu Glu Leu Asn  Asp Tyr Asn Ala Phe  Pro Glu Glu 
    1460                 1465                 1470             


Asn Met  Asn Tyr Ala Asn Gly  Phe Pro Cys Pro Ala  Asp Val Gln 
    1475                 1480                 1485             


Thr Asp  Phe Ile Asp His Asn  Ser Gln Ser Thr Trp  Asn Thr Pro 
    1490                 1495                 1500             


Pro Asn  Met Pro Ala Ala Trp  Gly His Ala Ser Phe  Ile Ser Ser 
    1505                 1510                 1515             


Pro Pro  Tyr Leu Thr Ser Thr  Arg Ser Leu Ser Pro  Met Ser Gly 
    1520                 1525                 1530             


Leu Phe  Gly Ser Ile Trp Ala  Pro Gln Ser Asp Val  Tyr Glu Asn 
    1535                 1540                 1545             


Cys Cys  Pro Ile Asn Pro Thr  Thr Glu His Ser Thr  His Met Glu 
    1550                 1555                 1560             


Asn Gln  Ala Val Val Cys Lys  Glu Tyr Tyr Pro Gly  Phe Asn Pro 
    1565                 1570                 1575             


Phe Arg  Ala Tyr Met Asn Leu  Asp Ile Trp Thr Thr  Thr Ala Asn 
    1580                 1585                 1590             


Arg Asn  Ala Asn Phe Pro Leu  Ser Arg Asp Ser Ser  Tyr Cys Gly 
    1595                 1600                 1605             


Asn Val  
    1610 


<210>  5843
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1024__Homo_sapiens__NP_056021

<400>  5843

Met Glu Thr Ser Gln Glu Thr Ser Leu Phe Leu Val Lys Ile Leu Glu 
1               5                   10                  15      


Glu Leu Asp Ser Lys Gln Asn Thr Val Ser Tyr Gln Asp Leu Cys Lys 
            20                  25                  30          


Ser Leu Cys Ala Arg Phe Asp Leu Ser Gln Leu Ala Lys Leu Arg Ser 
        35                  40                  45              


Val Leu Phe Tyr Thr Ala Cys Leu Asp Pro Asn Phe Pro Ala Thr Leu 
    50                  55                  60                  


Phe Lys Asp Lys Met Lys Cys Thr Val Asn Asn Gln Gln Ser Lys Lys 
65                  70                  75                  80  


Ile Met Val Ala Ala Asp Ile Val Thr Ile Phe Asn Leu Ile Gln Met 
                85                  90                  95      


Asn Gly Gly Ala Ala Lys Glu Lys Leu Pro Thr Gly Arg Gln Lys Val 
            100                 105                 110         


Arg Lys Lys Glu Ala Ser Phe Glu Ser Cys Arg Ser Asp Thr Glu Ile 
        115                 120                 125             


Cys Asn Ala Ala Glu Cys Glu Pro Leu Asn Cys Glu Leu Ser Glu Arg 
    130                 135                 140                 


Ser Phe Ser Arg Gly Tyr Pro Ile Arg Gln Ser Ser Lys Cys Arg Lys 
145                 150                 155                 160 


Met Asp Cys Lys Asp Cys Pro Gln Phe Val Pro Ala Ser Glu Pro Asn 
                165                 170                 175     


Phe Leu Leu Gly Val Ser Lys Glu Val Lys Asn Arg Ala Ala Ser Leu 
            180                 185                 190         


Asp Arg Leu Gln Ala Leu Ala Pro Tyr Ser Val Thr Ser Pro Gln Pro 
        195                 200                 205             


Cys Glu Met Gln Arg Thr Tyr Phe Pro Met Asn Ile Glu Asn Glu Ser 
    210                 215                 220                 


Ile Ser Asp Gln Asp Ser Leu Pro Ile Asn Gln Ser Ile Lys Glu Thr 
225                 230                 235                 240 


Phe Ile Ser Asn Glu Glu Pro Phe Val Val Gln Ser Cys Val Gln Lys 
                245                 250                 255     


Arg Asn Ile Phe Lys Glu Asp Phe His Asn Leu Met Ala Val Ser Pro 
            260                 265                 270         


Ser Leu Val Gly Pro Ile Ser Lys Ala Glu Asn Glu His Arg Glu Pro 
        275                 280                 285             


Gln Ser Arg Lys Glu Pro His Lys Pro Pro Phe Phe Asn His Ser Phe 
    290                 295                 300                 


Glu Met Pro Tyr Asn Ser Gln Tyr Leu Asn Pro Val Tyr Ser Pro Val 
305                 310                 315                 320 


Pro Asp Lys Arg Arg Ala Lys His Glu Ser Leu Asp Asp Leu Gln Ala 
                325                 330                 335     


Ser Thr Tyr Phe Gly Pro Thr Pro Val Met Gly Thr Gln Glu Ala Arg 
            340                 345                 350         


Arg Cys Leu Gly Lys Pro Asn Lys Gln Thr Pro Trp Pro Ala Lys Ser 
        355                 360                 365             


Trp Ser Leu Asn Thr Glu Glu Val Pro Asp Phe Glu Arg Ser Phe Phe 
    370                 375                 380                 


Asn Arg Asn Pro Ser Glu Glu Lys Leu His Tyr Pro Asn Ala Ser Ser 
385                 390                 395                 400 


Gln Thr Pro Asn Phe Pro Ala Pro Glu Arg Arg Pro Thr Tyr Leu Val 
                405                 410                 415     


Pro Lys Asp Gln Gln Pro Ile Leu Pro Ile Ala Tyr Ala Ala Lys Gln 
            420                 425                 430         


Asn Gly Leu Lys Ser Lys Glu Ile Ser Ser Pro Val Asp Leu Glu Lys 
        435                 440                 445             


His Glu Pro Val Lys Lys Phe Lys Asp Lys Ser Ile Asn Cys Thr Ser 
    450                 455                 460                 


Gly Gln Leu Ser Ser Asp Thr Ser Ser Val Gly Thr Gln Thr Glu His 
465                 470                 475                 480 


Val Leu Glu Pro Lys Lys Cys Arg Asp Leu Cys Thr Ser Gly Gln Gly 
                485                 490                 495     


Lys Tyr Ser Asp Arg His Thr Met Lys His Ser Asp Asp Asp Ser Glu 
            500                 505                 510         


Ile Val Ser Asp Asp Ile Ser Asp Ile Phe Arg Phe Leu Asp Asp Met 
        515                 520                 525             


Ser Ile Ser Gly Ser Thr Gly Val Ile Gln Ser Ser Cys Tyr Asn Ser 
    530                 535                 540                 


Thr Gly Ser Leu Ser Gln Leu His Lys Ser Asp Cys Asp Ser Ser Pro 
545                 550                 555                 560 


Glu His Asn Leu Thr Lys Ile Ala Asn Gly Val Pro Asn Ser Lys Gly 
                565                 570                 575     


Asp Lys Gly Asn Arg Pro Glu Asn Thr His His Ser Glu Glu Glu Leu 
            580                 585                 590         


Lys Thr Ser Val Cys Lys Leu Val Leu Arg Ile Gly Glu Ile Glu Arg 
        595                 600                 605             


Lys Leu Glu Ser Leu Ser Gly Val Arg Asp Glu Ile Ser Gln Val Leu 
    610                 615                 620                 


Gly Lys Leu Asn Lys Leu Asp Gln Lys Met Gln Gln Pro Glu Lys Val 
625                 630                 635                 640 


Ser Val Gln Ile Asp Leu Asn Ser Leu Thr Ser Glu Gly Pro Ser Asp 
                645                 650                 655     


Asp Ser Ala Ser Pro Arg Met Phe His Ala His Ser Gly Ser His Gly 
            660                 665                 670         


Pro Lys Leu Glu Asn Asn Pro Asp Trp Cys Cys Ser Asp Ala Ser Gly 
        675                 680                 685             


Ser Asn Ser Glu Ser Leu Arg Val Lys Ala Leu Lys Lys Ser Leu Phe 
    690                 695                 700                 


Thr Arg Pro Ser Ser Arg Ser Leu Thr Glu Glu Asn Ser Ala Thr Glu 
705                 710                 715                 720 


Ser Lys Ile Ala Ser Ile Ser Asn Ser Pro Arg Asp Trp Arg Thr Ile 
                725                 730                 735     


Thr Tyr Thr Asn Arg Val Gly Leu Asn Glu Glu Glu Ile Lys Asp Thr 
            740                 745                 750         


Gly Pro Gly Asp Asn Lys Asp Trp His Arg Lys Ser Lys Glu Ala Asp 
        755                 760                 765             


Arg Gln Tyr Asp Ile Pro Pro Gln His Arg Leu Pro Lys Gln Pro Lys 
    770                 775                 780                 


Asp Gly Phe Leu Val Glu Gln Val Phe Ser Pro His Pro Tyr Pro Ala 
785                 790                 795                 800 


Ser Leu Lys Ala His Met Lys Ser Asn Pro Leu Tyr Thr Asp Met Arg 
                805                 810                 815     


Leu Thr Glu Leu Ala Glu Val Lys Arg Gly Gln Pro Ser Trp Thr Ile 
            820                 825                 830         


Glu Glu Tyr Ala Arg Asn Ala Gly Asp Lys Gly Lys Leu Thr Ala Leu 
        835                 840                 845             


Asp Leu Gln Thr Gln Glu Ser Leu Asn Pro Asn Asn Leu Glu Tyr Trp 
    850                 855                 860                 


Met Glu Asp Ile Tyr Thr Pro Gly Tyr Asp Ser Leu Leu Lys Arg Lys 
865                 870                 875                 880 


Glu Ala Glu Phe Arg Arg Ala Lys Val Cys Lys Ile Ala Ala Leu Ile 
                885                 890                 895     


Ala Ala Ala Ala Cys Thr Val Ile Leu Val Ile Val Val Pro Ile Cys 
            900                 905                 910         


Thr Met Lys Ser 
        915     


<210>  5844
<211>  1173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1033__Homo_sapiens__NP_056090

<400>  5844

Met Ala Val Glu Thr Leu Ser Pro Asp Trp Glu Phe Asp Arg Val Asp 
1               5                   10                  15      


Asp Gly Ser Gln Lys Ile His Ala Glu Val Gln Leu Lys Asn Tyr Gly 
            20                  25                  30          


Lys Phe Leu Glu Glu Tyr Thr Ser Gln Leu Arg Arg Ile Glu Asp Ala 
        35                  40                  45              


Leu Asp Asp Ser Ile Gly Asp Val Trp Asp Phe Asn Leu Asp Pro Ile 
    50                  55                  60                  


Ala Leu Lys Leu Leu Pro Tyr Glu Gln Ser Ser Leu Leu Glu Leu Ile 
65                  70                  75                  80  


Lys Thr Glu Asn Lys Val Leu Asn Lys Val Ile Thr Val Tyr Ala Ala 
                85                  90                  95      


Leu Cys Cys Glu Ile Lys Lys Leu Lys Tyr Glu Ala Glu Thr Lys Phe 
            100                 105                 110         


Tyr Asn Gly Leu Leu Phe Tyr Gly Glu Gly Ala Thr Asp Ala Ser Met 
        115                 120                 125             


Val Glu Gly Asp Cys Gln Ile Gln Met Gly Arg Phe Ile Ser Phe Leu 
    130                 135                 140                 


Gln Glu Leu Ser Cys Phe Val Thr Arg Cys Tyr Glu Val Val Met Asn 
145                 150                 155                 160 


Val Val His Gln Leu Ala Ala Leu Tyr Ile Ser Asn Lys Ile Ala Pro 
                165                 170                 175     


Lys Ile Ile Glu Thr Thr Gly Val His Phe Gln Thr Met Tyr Glu His 
            180                 185                 190         


Leu Gly Glu Leu Leu Thr Val Leu Leu Thr Leu Asp Glu Ile Ile Asp 
        195                 200                 205             


Asn His Ile Thr Leu Lys Asp His Trp Thr Met Tyr Lys Arg Leu Leu 
    210                 215                 220                 


Lys Ser Val His His Asn Pro Ser Lys Phe Gly Ile Gln Glu Glu Lys 
225                 230                 235                 240 


Leu Lys Pro Phe Glu Lys Phe Leu Leu Lys Leu Glu Gly Gln Leu Leu 
                245                 250                 255     


Asp Gly Met Ile Phe Gln Ala Cys Ile Glu Gln Gln Phe Asp Ser Leu 
            260                 265                 270         


Asn Gly Gly Val Ser Val Ser Lys Asn Ser Thr Phe Ala Glu Glu Phe 
        275                 280                 285             


Ala His Ser Ile Arg Ser Ile Phe Ala Asn Val Glu Ala Lys Leu Gly 
    290                 295                 300                 


Glu Pro Ser Glu Ile Asp Gln Arg Asp Lys Tyr Val Gly Ile Cys Gly 
305                 310                 315                 320 


Leu Phe Val Leu His Phe Gln Ile Phe Arg Thr Ile Asp Lys Lys Phe 
                325                 330                 335     


Tyr Lys Ser Leu Leu Asp Ile Cys Lys Lys Val Pro Ala Ile Thr Leu 
            340                 345                 350         


Thr Ala Asn Ile Ile Trp Phe Pro Asp Asn Phe Leu Ile Gln Lys Ile 
        355                 360                 365             


Pro Ala Ala Ala Lys Leu Leu Asp Arg Lys Ser Leu Gln Ala Ile Lys 
    370                 375                 380                 


Ile His Arg Asp Thr Phe Leu Gln Gln Lys Ala Gln Ser Leu Thr Lys 
385                 390                 395                 400 


Asp Val Gln Ser Tyr Tyr Val Phe Val Ser Ser Trp Met Met Lys Met 
                405                 410                 415     


Glu Ser Ile Leu Ser Lys Glu Gln Arg Met Asp Lys Phe Ala Glu Asp 
            420                 425                 430         


Leu Thr Asn Arg Cys Asn Val Phe Ile Gln Gly Phe Leu Tyr Ala Tyr 
        435                 440                 445             


Ser Ile Ser Thr Ile Ile Lys Thr Thr Met Asn Leu Tyr Met Ser Met 
    450                 455                 460                 


Gln Lys Pro Met Thr Lys Thr Ser Val Lys Ala Leu Cys Arg Leu Val 
465                 470                 475                 480 


Glu Leu Leu Lys Ala Ile Glu His Met Phe Tyr Arg Arg Ser Met Val 
                485                 490                 495     


Val Ala Asp Ser Val Ser His Ile Thr Gln His Leu Gln His Gln Ala 
            500                 505                 510         


Leu His Ser Ile Ser Val Ala Lys Lys Arg Val Ile Ser Asp Lys Lys 
        515                 520                 525             


Tyr Ser Glu Gln Arg Leu Asp Val Leu Ser Ala Leu Val Leu Ala Glu 
    530                 535                 540                 


Asn Thr Leu Asn Gly Pro Ser Thr Lys Gln Arg Arg Leu Ile Val Ser 
545                 550                 555                 560 


Leu Ala Leu Ser Val Gly Thr Gln Met Lys Thr Phe Lys Asp Glu Glu 
                565                 570                 575     


Leu Phe Pro Leu Gln Val Val Met Lys Lys Leu Asp Leu Ile Ser Glu 
            580                 585                 590         


Leu Arg Glu Arg Val Gln Thr Gln Cys Asp Cys Cys Phe Leu Tyr Trp 
        595                 600                 605             


His Arg Ala Val Phe Pro Ile Tyr Leu Asp Asp Val Tyr Glu Asn Ala 
    610                 615                 620                 


Val Asp Ala Ala Arg Leu His Tyr Met Phe Ser Ala Leu Arg Asp Cys 
625                 630                 635                 640 


Val Pro Ala Met Met His Ala Arg His Leu Glu Ser Tyr Glu Ile Leu 
                645                 650                 655     


Leu Asp Cys Tyr Asp Lys Glu Ile Met Glu Ile Leu Asn Glu His Leu 
            660                 665                 670         


Leu Asp Lys Leu Cys Lys Glu Ile Glu Lys Asp Leu Arg Leu Ser Val 
        675                 680                 685             


His Thr His Leu Lys Leu Asp Asp Arg Asn Pro Phe Lys Val Gly Met 
    690                 695                 700                 


Lys Asp Leu Ala Leu Phe Phe Ser Leu Asn Pro Ile Arg Phe Phe Asn 
705                 710                 715                 720 


Arg Phe Ile Asp Ile Arg Ala Tyr Val Thr His Tyr Leu Asp Lys Thr 
                725                 730                 735     


Phe Tyr Asn Leu Thr Thr Val Ala Leu His Asp Trp Ala Thr Tyr Ser 
            740                 745                 750         


Glu Met Arg Asn Leu Ala Thr Gln Arg Tyr Gly Leu Val Met Thr Glu 
        755                 760                 765             


Ala His Leu Pro Ser Gln Thr Leu Glu Gln Gly Leu Asp Val Leu Glu 
    770                 775                 780                 


Ile Met Arg Asn Ile His Ile Phe Val Ser Arg Tyr Leu Tyr Asn Leu 
785                 790                 795                 800 


Asn Asn Gln Ile Phe Ile Glu Arg Thr Ser Asn Asn Lys His Leu Asn 
                805                 810                 815     


Thr Ile Asn Ile Arg His Ile Ala Asn Ser Ile Arg Thr His Gly Thr 
            820                 825                 830         


Gly Ile Met Asn Thr Thr Val Asn Phe Thr Tyr Gln Phe Leu Lys Lys 
        835                 840                 845             


Lys Phe Tyr Ile Phe Ser Gln Phe Met Tyr Asp Glu His Ile Lys Ser 
    850                 855                 860                 


Arg Leu Ile Lys Asp Ile Arg Phe Phe Arg Glu Ile Lys Asp Gln Asn 
865                 870                 875                 880 


Asp His Lys Tyr Pro Phe Asp Arg Ala Glu Lys Phe Asn Arg Gly Ile 
                885                 890                 895     


Arg Lys Leu Gly Val Thr Pro Glu Gly Gln Ser Tyr Leu Asp Gln Phe 
            900                 905                 910         


Arg Gln Leu Ile Ser Gln Ile Gly Asn Ala Met Gly Tyr Val Arg Met 
        915                 920                 925             


Ile Arg Ser Gly Gly Leu His Cys Ser Ser Asn Ala Ile Arg Phe Val 
    930                 935                 940                 


Pro Asp Leu Glu Asp Ile Val Asn Phe Glu Glu Leu Val Lys Glu Glu 
945                 950                 955                 960 


Gly Leu Ala Glu Glu Thr Leu Lys Ala Ala Arg His Leu Asp Ser Val 
                965                 970                 975     


Leu Ser Asp His Thr Arg Asn Ser Ala Glu Gly Thr Glu Tyr Phe Lys 
            980                 985                 990         


Met Leu Val Asp Val Phe Ala Pro  Glu Phe Arg Arg Pro  Lys Asn Ile 
        995                 1000                 1005             


His Leu  Arg Asn Phe Tyr Ile  Ile Val Pro Pro Leu  Thr Leu Asn 
    1010                 1015                 1020             


Phe Val  Glu His Ser Ile Ser  Cys Lys Glu Lys Leu  Asn Lys Lys 
    1025                 1030                 1035             


Asn Lys  Ile Gly Ala Ala Phe  Thr Asp Asp Gly Phe  Ala Met Gly 
    1040                 1045                 1050             


Val Ala  Tyr Ile Leu Lys Leu  Leu Asp Gln Tyr Arg  Glu Phe Asp 
    1055                 1060                 1065             


Ser Leu  His Trp Phe Gln Ser  Val Arg Glu Lys Tyr  Leu Lys Glu 
    1070                 1075                 1080             


Ile Arg  Ala Val Ala Lys Gln  Gln Asn Val Gln Ser  Ala Ser Gln 
    1085                 1090                 1095             


Asp Glu  Lys Leu Leu Gln Thr  Met Asn Leu Thr Gln  Lys Arg Leu 
    1100                 1105                 1110             


Asp Val  Tyr Leu Gln Glu Phe  Glu Leu Leu Tyr Phe  Ser Leu Ser 
    1115                 1120                 1125             


Ser Ala  Arg Ile Phe Phe Arg  Ala Asp Lys Thr Ala  Ala Glu Glu 
    1130                 1135                 1140             


Asn Gln  Glu Lys Lys Glu Lys  Glu Glu Glu Thr Lys  Thr Ser Asn 
    1145                 1150                 1155             


Gly Asp  Leu Ser Asp Ser Thr  Val Ser Ala Asp Pro  Val Val Lys 
    1160                 1165                 1170             


<210>  5845
<211>  5005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1109__Homo_sapiens__XP_005263344

<400>  5845

Met Asp Gln Arg Lys Asn Glu Ser Ile Val Pro Ser Ile Thr Gln Leu 
1               5                   10                  15      


Glu Asp Phe Leu Thr Glu His Asn Ser Asn Val Val Trp Leu Leu Val 
            20                  25                  30          


Ala Thr Ile Leu Ser Cys Gly Trp Ile Ile Tyr Leu Thr Tyr Tyr Asn 
        35                  40                  45              


Ser Arg Asn Val Gly Leu Ile Leu Thr Leu Val Leu Asn Arg Leu Tyr 
    50                  55                  60                  


Lys His Gly Tyr Ile His Ile Gly Ser Phe Ser Phe Ser Val Leu Ser 
65                  70                  75                  80  


Gly Lys Val Met Val Arg Glu Ile Tyr Tyr Ile Thr Glu Asp Met Ser 
                85                  90                  95      


Ile Arg Ile Gln Asp Gly Phe Ile Ile Phe Arg Trp Trp Lys Met Tyr 
            100                 105                 110         


Asn Pro Lys Gln Lys Gln His Asp Pro Lys Ala Glu Thr Arg Leu Tyr 
        115                 120                 125             


Ile Thr Val Asn Asp Phe Glu Phe His Val Tyr Asn Arg Ser Asp Leu 
    130                 135                 140                 


Tyr Gly Arg Leu Gln Glu Leu Phe Gly Leu Glu Pro Thr Ile Ile Pro 
145                 150                 155                 160 


Pro Lys Lys Asp Asp Asp Lys Thr Arg Glu Ile Gly Arg Thr Arg Thr 
                165                 170                 175     


Gln Ser Lys Ile Glu Arg Val Lys Val Lys Thr Glu Ser Gln Asp Pro 
            180                 185                 190         


Thr Ser Ser Trp Arg Ser Leu Ile Pro Val Ile Lys Val Asn Val Ser 
        195                 200                 205             


Thr Gly Arg Leu Ala Phe Gly Asn His Tyr Gln Pro Gln Thr Leu Cys 
    210                 215                 220                 


Ile Asn Phe Asp Asp Ala Phe Leu Thr Tyr Thr Thr Lys Pro Pro Ser 
225                 230                 235                 240 


Ser His Leu Asp Gln Phe Met His Ile Val Lys Gly Lys Leu Glu Asn 
                245                 250                 255     


Val Arg Val Met Leu Val Pro Ser Pro Arg Tyr Val Gly Leu Gln Asn 
            260                 265                 270         


Asp Glu Pro Pro Arg Leu Met Gly Glu Gly Phe Val Val Met Gln Ser 
        275                 280                 285             


Asn Asp Val Asp Ile Tyr Tyr Tyr Met Asp Glu Pro Gly Leu Val Pro 
    290                 295                 300                 


Glu Glu Thr Glu Glu Asn Ile Glu Gly Glu Met Ser Ser Glu Asp Cys 
305                 310                 315                 320 


Lys Leu Gln Asp Leu Pro Pro Cys Trp Gly Leu Asp Ile Val Cys Gly 
                325                 330                 335     


Lys Gly Thr Asp Phe Asn Tyr Gly Pro Trp Ala Asp Arg Gln Arg Asp 
            340                 345                 350         


Cys Leu Trp Lys Phe Phe Phe Pro Pro Asp Tyr Gln Val Leu Lys Val 
        355                 360                 365             


Ser Glu Ile Ala Gln Pro Gly Arg Pro Arg Gln Ile Leu Ala Phe Glu 
    370                 375                 380                 


Leu Arg Met Asn Ile Ile Ala Asp Ala Thr Ile Asp Leu Leu Phe Thr 
385                 390                 395                 400 


Lys Asn Arg Glu Thr Asn Ala Val His Val Asn Val Gly Ala Gly Ser 
                405                 410                 415     


Tyr Leu Glu Ile Asn Ile Pro Met Thr Val Glu Glu Asn Gly Tyr Thr 
            420                 425                 430         


Pro Ala Ile Lys Gly Gln Leu Leu His Val Asp Ala Thr Thr Ser Met 
        435                 440                 445             


Gln Tyr Arg Thr Leu Leu Glu Ala Glu Met Leu Ala Phe His Ile Asn 
    450                 455                 460                 


Ala Ser Tyr Pro Arg Ile Trp Asn Met Pro Gln Thr Trp Gln Cys Glu 
465                 470                 475                 480 


Leu Glu Val Tyr Lys Ala Thr Tyr His Phe Ile Phe Ala Gln Lys Asn 
                485                 490                 495     


Phe Phe Thr Asp Leu Ile Gln Asp Trp Ser Ser Asp Ser Pro Pro Asp 
            500                 505                 510         


Ile Phe Ser Phe Val Pro Tyr Thr Trp Asn Phe Lys Ile Met Phe His 
        515                 520                 525             


Gln Phe Glu Met Ile Trp Ala Ala Asn Gln His Asn Trp Ile Asp Cys 
    530                 535                 540                 


Ser Thr Lys Gln Gln Glu Asn Val Tyr Leu Ala Ala Cys Gly Glu Thr 
545                 550                 555                 560 


Leu Asn Ile Asp Phe Ser Leu Pro Phe Thr Asp Phe Val Pro Ala Thr 
                565                 570                 575     


Cys Asn Thr Lys Phe Ser Leu Arg Gly Glu Asp Val Asp Leu His Leu 
            580                 585                 590         


Phe Leu Pro Asp Cys His Pro Ser Lys Tyr Ser Leu Phe Met Leu Val 
        595                 600                 605             


Lys Asn Cys His Pro Asn Lys Met Ile His Asp Thr Gly Ile Pro Ala 
    610                 615                 620                 


Glu Cys Gln Ser Gly Gln Lys Thr Val Lys Pro Lys Trp Arg Asn Val 
625                 630                 635                 640 


Thr Gln Glu Lys Ser Gly Trp Val Glu Cys Trp Thr Val Pro Ser Val 
                645                 650                 655     


Met Leu Thr Ile Asp Tyr Thr Trp His Pro Ile Tyr Pro Gln Lys Ala 
            660                 665                 670         


Asp Glu Gln Leu Lys Gln Ser Leu Ser Glu Met Glu Glu Thr Met Leu 
        675                 680                 685             


Ser Val Leu Arg Pro Ser Gln Lys Thr Ser Asp Arg Val Val Ser Ser 
    690                 695                 700                 


Pro Ser Thr Ser Ser Arg Pro Pro Ile Asp Pro Ser Glu Leu Pro Pro 
705                 710                 715                 720 


Asp Lys Leu His Val Glu Met Glu Leu Ser Pro Asp Ser Gln Ile Thr 
                725                 730                 735     


Leu Tyr Gly Pro Leu Leu Asn Ala Phe Leu Cys Ile Lys Glu Asn Tyr 
            740                 745                 750         


Phe Gly Glu Asp Asp Met Tyr Met Asp Phe Glu Glu Val Ile Ser Ser 
        755                 760                 765             


Pro Val Leu Ser Leu Ser Thr Ser Ser Ser Ser Gly Trp Thr Ala Val 
    770                 775                 780                 


Gly Met Glu Asn Asp Lys Lys Glu Asn Glu Gly Ser Ala Lys Ser Ile 
785                 790                 795                 800 


His Pro Leu Ala Leu Arg Pro Trp Asp Ile Thr Val Leu Val Asn Leu 
                805                 810                 815     


Tyr Lys Val His Gly Arg Leu Pro Val His Gly Thr Thr Asp Gly Pro 
            820                 825                 830         


Glu Cys Pro Thr Ala Phe Leu Glu Arg Leu Cys Phe Glu Met Lys Lys 
        835                 840                 845             


Gly Phe Arg Glu Thr Met Leu Gln Leu Ile Leu Ser Pro Leu Asn Val 
    850                 855                 860                 


Phe Val Ser Asp Asn Tyr Gln Gln Arg Pro Pro Val Asp Glu Val Leu 
865                 870                 875                 880 


Arg Glu Gly His Ile Asn Leu Ser Gly Leu Gln Leu Arg Ala His Ala 
                885                 890                 895     


Met Phe Ser Ala Glu Gly Leu Pro Leu Gly Ser Asp Ser Leu Glu Tyr 
            900                 905                 910         


Ala Trp Leu Ile Asp Val Gln Ala Gly Ser Leu Thr Ala Lys Val Thr 
        915                 920                 925             


Ala Pro Gln Leu Ala Cys Leu Leu Glu Trp Gly Gln Thr Phe Val Phe 
    930                 935                 940                 


His Val Val Cys Arg Glu Tyr Glu Leu Glu Arg Pro Lys Ser Val Ile 
945                 950                 955                 960 


Ile Cys Gln His Gly Ile Asp Arg Arg Phe Cys Glu Ser Lys Leu Ser 
                965                 970                 975     


Cys Ile Pro Gly Pro Cys Pro Thr Ser Asp Asp Leu Lys Tyr Thr Met 
            980                 985                 990         


Ile Arg Leu Ala Val Asp Gly Ala  Asp Ile Tyr Ile Val  Glu His Gly 
        995                 1000                 1005             


Cys Ala  Thr Asn Ile Lys Met  Gly Ala Ile Arg Val  Ala Asn Cys 
    1010                 1015                 1020             


Asn Leu  His Asn Gln Ser Val  Gly Glu Gly Ile Ser  Ala Ala Ile 
    1025                 1030                 1035             


Gln Asp  Phe Gln Val Arg Gln  Tyr Ile Glu Gln Leu  Asn Asn Cys 
    1040                 1045                 1050             


Arg Ile  Gly Leu Gln Pro Ala  Val Leu Arg Arg Ala  Tyr Trp Leu 
    1055                 1060                 1065             


Glu Ala  Gly Ser Ala Asn Leu  Gly Leu Ile Thr Val  Asp Ile Ala 
    1070                 1075                 1080             


Leu Ala  Ala Asp His His Ser  Lys His Glu Ala Gln  Arg His Phe 
    1085                 1090                 1095             


Leu Glu  Thr His Asp Ala Arg  Thr Lys Arg Leu Trp  Phe Leu Trp 
    1100                 1105                 1110             


Pro Asp  Asp Ile Leu Lys Asn  Lys Arg Cys Arg Asn  Lys Cys Gly 
    1115                 1120                 1125             


Cys Leu  Gly Gly Cys Arg Phe  Phe Gly Gly Thr Val  Thr Gly Leu 
    1130                 1135                 1140             


Asp Phe  Phe Lys Leu Glu Glu  Leu Thr Pro Ser Ser  Ser Ser Ala 
    1145                 1150                 1155             


Phe Ser  Ser Thr Ser Ala Glu  Ser Asp Met Tyr Tyr  Gly Gln Ser 
    1160                 1165                 1170             


Leu Leu  Gln Pro Gly Glu Trp  Ile Ile Thr Lys Glu  Ile Pro Lys 
    1175                 1180                 1185             


Ile Ile  Asp Gly Asn Val Asn  Gly Met Lys Arg Lys  Glu Trp Glu 
    1190                 1195                 1200             


Asn Lys  Ser Val Gly Ile Glu  Val Glu Arg Lys Thr  Gln His Leu 
    1205                 1210                 1215             


Ser Leu  Gln Val Pro Leu Arg  Ser His Ser Ser Ser  Ser Ser Ser 
    1220                 1225                 1230             


Glu Glu  Asn Ser Ser Ser Ser  Ala Ala Gln Pro Leu  Leu Ala Gly 
    1235                 1240                 1245             


Glu Lys  Glu Ser Pro Ser Ser  Val Ala Asp Asp His  Leu Val Gln 
    1250                 1255                 1260             


Lys Glu  Phe Leu His Gly Thr  Lys Arg Asp Asp Gly  Gln Ala Ser 
    1265                 1270                 1275             


Ile Pro  Thr Glu Ile Ser Gly  Asn Ser Pro Val Ser  Pro Asn Thr 
    1280                 1285                 1290             


Gln Asp  Lys Ser Val Gly Gln  Ser Pro Leu Arg Ser  Pro Leu Lys 
    1295                 1300                 1305             


Arg Gln  Ala Ser Val Cys Ser  Thr Arg Leu Gly Ser  Thr Lys Ser 
    1310                 1315                 1320             


Leu Thr  Ala Ala Phe Tyr Gly  Asp Lys Gln Pro Val  Thr Val Gly 
    1325                 1330                 1335             


Val Gln  Phe Ser Ser Asp Val  Ser Arg Ser Asp Glu  Asn Val Leu 
    1340                 1345                 1350             


Asp Ser  Pro Lys Gln Arg Arg  Ser Phe Gly Ser Phe  Pro Tyr Thr 
    1355                 1360                 1365             


Pro Ser  Ala Asp Ser Asn Ser  Phe His Gln Tyr Arg  Ser Met Asp 
    1370                 1375                 1380             


Ser Ser  Met Ser Met Ala Asp  Ser Glu Ala Tyr Phe  Ser Ala Ala 
    1385                 1390                 1395             


Glu Glu  Phe Glu Pro Ile Ser  Ser Asp Glu Gly Pro  Gly Thr Tyr 
    1400                 1405                 1410             


Pro Gly  Arg Lys Lys Lys Lys  Lys Gln Thr Gln Gln  Ile Asp Tyr 
    1415                 1420                 1425             


Ser Arg  Gly Ser Ile Tyr His  Ser Val Glu Gly Pro  Leu Thr Gly 
    1430                 1435                 1440             


His Gly  Glu Ser Ile Gln Asp  Ser Arg Thr Leu Pro  Phe Lys Thr 
    1445                 1450                 1455             


His Pro  Ser Gln Ala Ser Phe  Val Ser Ala Leu Gly  Gly Glu Asp 
    1460                 1465                 1470             


Asp Val  Ile Glu His Leu Tyr  Ile Val Glu Gly Glu  Lys Thr Val 
    1475                 1480                 1485             


Glu Ser  Glu Gln Ile Thr Pro  Gln Gln Pro Val Met  Asn Cys Tyr 
    1490                 1495                 1500             


Gln Thr  Tyr Leu Thr Gln Phe  Gln Val Ile Asn Trp  Ser Val Lys 
    1505                 1510                 1515             


His Pro  Thr Asn Lys Arg Thr  Ser Lys Ser Ser Leu  His Arg Pro 
    1520                 1525                 1530             


Leu Asp  Leu Asp Thr Pro Thr  Ser Glu Glu Ser Ser  Ser Ser Phe 
    1535                 1540                 1545             


Glu Gln  Leu Ser Val Pro Thr  Phe Lys Val Ile Lys  Gln Gly Leu 
    1550                 1555                 1560             


Thr Ala  Asn Ser Leu Leu Asp  Arg Gly Met Gln Leu  Ser Gly Ser 
    1565                 1570                 1575             


Thr Ser  Asn Thr Pro Tyr Thr  Pro Leu Glu Lys Lys  Leu Ala Asp 
    1580                 1585                 1590             


Asn Thr  Asp Asp Glu Thr Leu  Thr Glu Glu Trp Thr  Leu Asp Gln 
    1595                 1600                 1605             


Pro Val  Ser Gln Thr Arg Thr  Thr Ala Ile Val Glu  Val Lys Gly 
    1610                 1615                 1620             


Thr Val  Asp Ile Val Leu Thr  Pro Leu Val Ala Glu  Ala Leu Asp 
    1625                 1630                 1635             


Arg Tyr  Ile Glu Ala Met Val  His Cys Ala Ser Thr  Arg His Pro 
    1640                 1645                 1650             


Ala Ala  Ile Val Asp Asp Leu  His Ala Lys Val Leu  Arg Glu Ala 
    1655                 1660                 1665             


Val Gln  Asn Ser Lys Thr Thr  Phe Ser Glu Asn Leu  Ser Ser Lys 
    1670                 1675                 1680             


Gln Asp  Ile Arg Gly Thr Lys  Thr Glu Gln Ser Thr  Ile Gly Thr 
    1685                 1690                 1695             


Thr Asn  Gln Gly Gln Ala Gln  Thr Asn Leu Thr Met  Lys Gln Asp 
    1700                 1705                 1710             


Asn Val  Thr Ile Lys Gly Leu  Gln Thr Asn Val Ser  Ile Pro Lys 
    1715                 1720                 1725             


Val Asn  Leu Cys Leu Leu Gln  Ala Ser Val Glu Glu  Ser Pro Thr 
    1730                 1735                 1740             


Thr Ala  Pro Ser Arg Ser Val  Thr His Val Ser Leu  Val Ala Leu 
    1745                 1750                 1755             


Cys Phe  Asp Arg Ile Ala Thr  Gln Val Arg Met Asn  Arg Gly Val 
    1760                 1765                 1770             


Val Glu  Glu Thr Ser Asn Asn  Ala Glu Pro Gly Arg  Thr Ser Asn 
    1775                 1780                 1785             


Phe Asp  Arg Tyr Val His Ala  Thr Lys Met Gln Pro  Gln Ser Ser 
    1790                 1795                 1800             


Gly Ser  Leu Arg Ser Asn Ala  Gly Ala Glu Lys Gly  Lys Glu Ile 
    1805                 1810                 1815             


Ala Ala  Lys Leu Asn Ile His  Arg Val His Gly Gln  Leu Arg Gly 
    1820                 1825                 1830             


Leu Asp  Thr Thr Asp Ile Gly  Thr Cys Ala Ile Thr  Ala Ile Pro 
    1835                 1840                 1845             


Phe Glu  Lys Ser Lys Val Leu  Phe Thr Leu Glu Glu  Leu Asp Glu 
    1850                 1855                 1860             


Phe Thr  Phe Val Asp Glu Thr  Asp Gln Gln Ala Val  Pro Asp Val 
    1865                 1870                 1875             


Thr Arg  Ile Gly Pro Ser Gln  Glu Lys Trp Gly Trp  Ile Met Phe 
    1880                 1885                 1890             


Glu Cys  Gly Leu Glu Asn Leu  Thr Ile Lys Gly Gly  Arg Gln Ser 
    1895                 1900                 1905             


Gly Ala  Val Leu Tyr Asn Ser  Phe Gly Ile Met Gly  Lys Ala Ser 
    1910                 1915                 1920             


Asp Thr  Glu Arg Gly Gly Val  Leu Thr Ser Asn Asn  Ser Ser Asp 
    1925                 1930                 1935             


Ser Pro  Thr Gly Ser Gly Tyr  Asn Thr Asp Val Ser  Asp Asp Asn 
    1940                 1945                 1950             


Leu Pro  Cys Asp Arg Thr Ser  Pro Ser Ser Asp Leu  Asn Gly Asn 
    1955                 1960                 1965             


Ser Val  Ser Asp Glu Gln Asp  Glu Gly Val Glu Ser  Asp Asp Leu 
    1970                 1975                 1980             


Lys Lys  Asp Leu Pro Leu Met  Pro Pro Pro Pro Asp  Ser Cys Ser 
    1985                 1990                 1995             


Met Lys  Leu Thr Ile Lys Glu  Ile Trp Phe Ser Phe  Ala Ala Pro 
    2000                 2005                 2010             


Thr Asn  Val Arg Ser His Thr  His Ala Phe Ser Arg  Gln Leu Asn 
    2015                 2020                 2025             


Leu Leu  Ser Thr Ala Thr Pro  Ala Val Gly Ala Trp  Leu Val Pro 
    2030                 2035                 2040             


Ile Asp  Gln Leu Lys Ser Ser  Leu Asn Lys Leu Glu  Thr Glu Gly 
    2045                 2050                 2055             


Thr Leu  Arg Ile Cys Ala Val  Met Gly Cys Ile Met  Thr Glu Ala 
    2060                 2065                 2070             


Leu Glu  Asn Lys Ser Val His  Phe Pro Leu Arg Ser  Lys Tyr Asn 
    2075                 2080                 2085             


Arg Leu  Thr Lys Val Ala Arg  Phe Leu Gln Glu Asn  Pro Ser Cys 
    2090                 2095                 2100             


Leu Leu  Cys Asn Ile Leu His  His Tyr Leu His Gln  Ala Asn Tyr 
    2105                 2110                 2115             


Ser Ile  Ile Asp Asp Ala Thr  Met Ser Asp Gly Leu  Pro Ala Leu 
    2120                 2125                 2130             


Val Thr  Leu Lys Lys Gly Leu  Val Ala Leu Ala Arg  Gln Trp Met 
    2135                 2140                 2145             


Lys Phe  Ile Val Val Thr Pro  Ala Phe Lys Gly Val  Ser Leu His 
    2150                 2155                 2160             


Arg Pro  Ala Gln Pro Leu Lys  Pro Gln Ile Ala Met  Asp His Glu 
    2165                 2170                 2175             


His Glu  Asp Gly Leu Gly Leu  Asp Asn Gly Gly Gly  Leu Gln Ser 
    2180                 2185                 2190             


Asp Thr  Ser Ala Asp Gly Ala  Glu Phe Glu Phe Asp  Ala Ala Thr 
    2195                 2200                 2205             


Val Ser  Glu His Thr Met Leu  Leu Glu Gly Thr Ala  Asn Arg Pro 
    2210                 2215                 2220             


Pro Pro  Gly Ser Ser Gly Pro  Val Thr Gly Ala Glu  Ile Met Arg 
    2225                 2230                 2235             


Lys Leu  Ser Lys Thr His Thr  His Ser Asp Ser Ala  Leu Lys Ile 
    2240                 2245                 2250             


Lys Gly  Ile His Pro Tyr His  Ser Leu Ser Tyr Thr  Ser Gly Asp 
    2255                 2260                 2265             


Thr Ala  Thr Asp Ser Pro Val  His Val Gly Arg Ala  Gly Met Pro 
    2270                 2275                 2280             


Val Lys  Asp Ser Pro Arg Lys  Glu Ser Leu Leu Ser  Tyr Leu Thr 
    2285                 2290                 2295             


Gly Ser  Phe Pro Ser Leu His  Asn Leu Leu Glu Gly  Thr Pro Gln 
    2300                 2305                 2310             


Arg Ser  Ser Ala Ala Val Lys  Ser Ser Ser Leu Thr  Arg Thr Gly 
    2315                 2320                 2325             


Asn Thr  Val Ala Thr Asp Met  Leu Ser Glu His Pro  Leu Leu Ser 
    2330                 2335                 2340             


Glu Pro  Ser Ser Val Ser Phe  Tyr Asn Trp Met Ser  Asn Ala Val 
    2345                 2350                 2355             


Gly Asn  Arg Gly Ser Val Leu  Gln Glu Ser Pro Val  Thr Lys Ser 
    2360                 2365                 2370             


Gly His  Asn Ser Leu Pro Thr  Gly Val Ala Pro Asn  Leu Pro Thr 
    2375                 2380                 2385             


Ile Pro  Ser Ala Ser Asp Phe  Asn Thr Val Leu Ser  Ser Asp Gln 
    2390                 2395                 2400             


Asn Thr  Leu Asp Gly Thr His  Ser Gln His Ser Thr  Ser Gln Asp 
    2405                 2410                 2415             


Asp Val  Ala Gly Val Glu Glu  Ala Asn Gln Gly Phe  Pro Ala Val 
    2420                 2425                 2430             


Gln Leu  Ala Asp Ala Gln Val  Val Phe Lys Pro Leu  Leu Ser His 
    2435                 2440                 2445             


Thr Gly  Ile Gln Ser Gln Asp  Thr Met Pro Phe Cys  Tyr Arg Met 
    2450                 2455                 2460             


Tyr Phe  Gly Glu His Leu Ser  Phe Ser Gly Thr Leu  Asp Cys Leu 
    2465                 2470                 2475             


Arg Ala  Asp Ile Val Asp Ser  Asp Thr Ala Lys Glu  Arg Lys Gly 
    2480                 2485                 2490             


Lys Arg  Ala Arg Arg Gln Gly  His Val Asn Leu Pro  Pro Leu Glu 
    2495                 2500                 2505             


Phe Lys  Pro Ala Leu Met Leu  Gly Thr Phe Ser Ile  Ser Ala Val 
    2510                 2515                 2520             


Val Met  Glu Lys Ser Val Cys  Thr Pro Gln Asn Ser  Thr Ser Ala 
    2525                 2530                 2535             


Leu Ser  Phe His Asp Leu Ser  Lys Arg Tyr Tyr Asn  Thr Phe His 
    2540                 2545                 2550             


Cys Asn  Phe Thr Ile Ser Cys  Gln Ser Ile Ser Gln  His Val Asp 
    2555                 2560                 2565             


Met Ala  Leu Val Arg Leu Ile  His Gln Phe Ser Thr  Met Ile Asp 
    2570                 2575                 2580             


Asp Ile  Lys Ala Thr Gln Thr  Asp Ile Lys Leu Ser  Arg Tyr Thr 
    2585                 2590                 2595             


Ala Gly  Ser Ala Ser Pro Thr  Pro Thr Phe Lys Thr  Arg Lys His 
    2600                 2605                 2610             


Arg Asp  Phe Arg Ser Ser Asp  Phe Ser Arg Ser Ser  Arg Gly Ser 
    2615                 2620                 2625             


Leu Asn  Gly Gly Asn Arg Val  Asn Asn Ala Lys Asn  Lys Arg Thr 
    2630                 2635                 2640             


Asn Asn  Glu Asn Asn Lys Lys  Glu Ser Arg Asn Lys  Asn Ser Leu 
    2645                 2650                 2655             


Gly Arg  Ser Glu Arg Arg Thr  Ser Lys Val Ser Arg  Lys Gly Ser 
    2660                 2665                 2670             


Lys Asp  Val Val Asp His Met  Thr Ile His Met Asp  Asp Ser Asp 
    2675                 2680                 2685             


Ser Ile  Thr Val Ser Glu Gln  Ser Glu Pro Ser Ala  Glu Cys Trp 
    2690                 2695                 2700             


Gln Asn  Met Tyr Lys Leu Leu  Asn Phe Tyr Ser Leu  Ile Ser Asp 
    2705                 2710                 2715             


Pro Thr  Gly Ile Leu Glu Lys  Ser Ser Glu Thr Phe  Gly Pro Ala 
    2720                 2725                 2730             


Gly Val  Arg Ser Pro Thr Glu  Pro Thr Cys Lys Val  Val Phe Glu 
    2735                 2740                 2745             


Asn Glu  Gln Asp Asn Ser Ser  Leu Thr Lys Thr Gln  Arg Lys Arg 
    2750                 2755                 2760             


Ser Leu  Val Thr Ser Glu Pro  Gln His Val Thr Leu  Ile Val Phe 
    2765                 2770                 2775             


Gly Ile  Gly Met Val Asn Arg  Thr His Leu Glu Ala  Asp Ile Gly 
    2780                 2785                 2790             


Gly Leu  Thr Met Glu Ser Glu  Leu Lys Arg Ile His  Gly Ser Phe 
    2795                 2800                 2805             


Thr Leu  Lys Glu Lys Met Lys  Asp Val Leu His Gln  Lys Met Thr 
    2810                 2815                 2820             


Glu Thr  Cys Ala Thr Ala His  Ile Gly Gly Val Asn  Ile Val Leu 
    2825                 2830                 2835             


Leu Glu  Gly Ile Thr Pro Asn  Ile Gln Leu Glu Asp  Phe Pro Thr 
    2840                 2845                 2850             


Ser Pro  Thr Ser Thr Ala Lys  Gln Glu Phe Leu Thr  Val Val Lys 
    2855                 2860                 2865             


Cys Ser  Ile Ala Lys Ser Gln  Ala Leu Tyr Ser Ala  Gln Arg Gly 
    2870                 2875                 2880             


Leu Lys  Thr Asn Asn Ala Ala  Val Phe Lys Val Gly  Ala Ile Ser 
    2885                 2890                 2895             


Ile Asn  Ile Pro Gln His Pro  Ala Thr Leu His Ser  Met Met Val 
    2900                 2905                 2910             


Arg Ser  Ser His Gln Leu Ser  Lys Gln Ile Ser Asp  Leu Ile Arg 
    2915                 2920                 2925             


Gln Pro  Ser Thr Ala Pro Gln  Pro Val Lys Glu Asp  Ile Ala Thr 
    2930                 2935                 2940             


Pro Leu  Pro Ser Glu Lys Thr  Pro Thr Ser Val Asn  Gln Thr Pro 
    2945                 2950                 2955             


Val Glu  Thr Asn Glu Phe Pro  Gln Leu Pro Glu Gly  Leu Glu Lys 
    2960                 2965                 2970             


Lys Pro  Ile Val Leu Lys Phe  Ser Ala Met Leu Asp  Gly Ile Ala 
    2975                 2980                 2985             


Ile Gly  Ala Ala Leu Leu Pro  Ser Leu Lys Ala Glu  Tyr Lys Met 
    2990                 2995                 3000             


Gly Arg  Met Arg Ser His Gly  Met Thr Gly Ala Gln  Thr Arg Phe 
    3005                 3010                 3015             


Thr Phe  Glu Leu Pro Asn His  Arg Leu Arg Phe Thr  Ser Lys Val 
    3020                 3025                 3030             


Ser Ala  Thr Asp Met Ser Thr  Ile Pro Pro Ser Ala  Ser Leu Asn 
    3035                 3040                 3045             


Leu Pro  Pro Val Thr Met Ser  Gly Lys Tyr Ile Met  Glu Glu His 
    3050                 3055                 3060             


Asp Ser  Tyr Ser Asp Gln Val  Trp Ser Ile Asp Glu  Leu Pro Ser 
    3065                 3070                 3075             


Lys Gln  Gly Tyr Tyr Leu Gln  Gly Asn Tyr Leu Arg  Cys Val Ala 
    3080                 3085                 3090             


Glu Val  Gly Ser Phe Glu His  Asn Leu Thr Thr Asp  Leu Leu Asn 
    3095                 3100                 3105             


His Leu  Val Phe Val Gln Lys  Val Phe Met Lys Glu  Val Asn Glu 
    3110                 3115                 3120             


Val Ile  Gln Lys Val Ser Gly  Gly Glu Gln Pro Ile  Pro Leu Trp 
    3125                 3130                 3135             


Asn Glu  His Asp Gly Thr Ala  Asp Gly Asp Lys Pro  Lys Ile Leu 
    3140                 3145                 3150             


Leu Tyr  Ser Leu Asn Leu Gln  Phe Lys Gly Ile Gln  Val Thr Ala 
    3155                 3160                 3165             


Thr Thr  Pro Ser Met Arg Ala  Val Arg Phe Glu Thr  Gly Leu Ile 
    3170                 3175                 3180             


Glu Leu  Glu Leu Ser Asn Arg  Leu Gln Thr Lys Ala  Ser Pro Gly 
    3185                 3190                 3195             


Ser Ser  Ser Tyr Leu Lys Leu  Phe Gly Lys Cys Gln  Val Asp Leu 
    3200                 3205                 3210             


Asn Leu  Ala Leu Gly Gln Ile  Val Lys His Gln Val  Tyr Glu Glu 
    3215                 3220                 3225             


Ala Gly  Ser Asp Phe His Gln  Val Ala Tyr Phe Lys  Thr Arg Ile 
    3230                 3235                 3240             


Gly Leu  Arg Asn Ala Leu Arg  Glu Glu Ile Ser Gly  Ser Ser Asp 
    3245                 3250                 3255             


Arg Glu  Ala Val Leu Ile Thr  Leu Asn Arg Pro Ile  Val Tyr Ala 
    3260                 3265                 3270             


Gln Pro  Val Ala Phe Asp Arg  Ala Val Leu Phe Trp  Leu Asn Tyr 
    3275                 3280                 3285             


Lys Ala  Ala Tyr Asp Asn Trp  Asn Glu Gln Arg Met  Ala Leu His 
    3290                 3295                 3300             


Lys Asp  Ile His Met Ala Thr  Lys Glu Val Val Asp  Met Leu Pro 
    3305                 3310                 3315             


Gly Ile  Gln Gln Thr Ser Ala  Gln Ala Phe Gly Thr  Leu Phe Leu 
    3320                 3325                 3330             


Gln Leu  Thr Val Asn Asp Leu  Gly Ile Cys Leu Pro  Ile Thr Asn 
    3335                 3340                 3345             


Thr Ala  Gln Ser Asn His Thr  Gly Asp Leu Asp Thr  Gly Ser Ala 
    3350                 3355                 3360             


Leu Val  Leu Thr Ile Glu Ser  Thr Leu Ile Thr Ala  Cys Ser Ser 
    3365                 3370                 3375             


Glu Ser  Leu Val Ser Lys Gly  His Phe Lys Asn Phe  Cys Ile Arg 
    3380                 3385                 3390             


Phe Ala  Asp Gly Phe Glu Thr  Ser Trp Asp Asp Trp  Lys Pro Glu 
    3395                 3400                 3405             


Ile His  Gly Asp Leu Val Met  Asn Ala Cys Val Val  Pro Asp Gly 
    3410                 3415                 3420             


Thr Tyr  Glu Val Cys Ser Arg  Thr Thr Gly Gln Ala  Ala Ala Glu 
    3425                 3430                 3435             


Ser Ser  Ser Ala Gly Thr Trp  Thr Leu Asn Val Leu  Trp Lys Met 
    3440                 3445                 3450             


Cys Gly  Ile Asp Val His Met  Asp Pro Asn Ile Gly  Lys Arg Leu 
    3455                 3460                 3465             


Asn Ala  Leu Gly Asn Thr Leu  Thr Thr Leu Thr Gly  Glu Glu Asp 
    3470                 3475                 3480             


Ile Asp  Asp Ile Ala Asp Leu  Asn Ser Val Asn Ile  Ala Asp Leu 
    3485                 3490                 3495             


Ser Asp  Glu Asp Glu Val Asp  Thr Met Ser Pro Thr  Ile His Thr 
    3500                 3505                 3510             


Glu Ala  Thr Asp Tyr Arg Arg  Gln Ala Ala Ser Ala  Ser Gln Pro 
    3515                 3520                 3525             


Gly Glu  Leu Arg Gly Arg Lys  Ile Met Lys Arg Ile  Val Asp Ile 
    3530                 3535                 3540             


Arg Glu  Leu Asn Glu Gln Ala  Lys Val Ile Asp Asp  Leu Lys Lys 
    3545                 3550                 3555             


Leu Gly  Ala Ser Glu Gly Thr  Ile Asn Gln Glu Ile  Gln Arg Tyr 
    3560                 3565                 3570             


Gln Gln  Leu Glu Ser Val Ala  Val Asn Asp Ile Arg  Arg Asp Val 
    3575                 3580                 3585             


Arg Lys  Lys Leu Arg Arg Ser  Ser Met Arg Ala Ala  Ser Leu Lys 
    3590                 3595                 3600             


Asp Lys  Trp Gly Leu Ser Tyr  Lys Pro Ser Tyr Ser  Arg Ser Lys 
    3605                 3610                 3615             


Ser Ile  Ser Ala Ser Gly Arg  Pro Pro Leu Lys Arg  Met Glu Arg 
    3620                 3625                 3630             


Ala Ser  Ser Arg Val Gly Glu  Thr Glu Glu Leu Pro  Glu Ile Arg 
    3635                 3640                 3645             


Val Asp  Ala Ala Ser Pro Gly  Pro Arg Val Thr Phe  Asn Ile Gln 
    3650                 3655                 3660             


Asp Thr  Phe Pro Glu Glu Thr  Glu Leu Asp Leu Leu  Ser Val Thr 
    3665                 3670                 3675             


Ile Glu  Gly Pro Ser His Tyr  Ser Ser Asn Ser Glu  Gly Ser Cys 
    3680                 3685                 3690             


Ser Val  Phe Ser Ser Pro Lys  Thr Pro Gly Gly Phe  Ser Pro Gly 
    3695                 3700                 3705             


Ile Pro  Phe Gln Thr Glu Glu  Gly Arg Arg Asp Asp  Ser Leu Ser 
    3710                 3715                 3720             


Ser Thr  Ser Glu Asp Ser Glu  Lys Asp Glu Lys Asp  Glu Asp His 
    3725                 3730                 3735             


Glu Arg  Glu Arg Phe Tyr Ile  Tyr Arg Lys Pro Ser  His Thr Ser 
    3740                 3745                 3750             


Arg Lys  Lys Ala Thr Gly Phe  Ala Ala Val His Gln  Leu Phe Thr 
    3755                 3760                 3765             


Glu Arg  Trp Pro Thr Thr Pro  Val Asn Arg Ser Leu  Ser Gly Thr 
    3770                 3775                 3780             


Ala Thr  Glu Arg Asn Ile Asp  Phe Glu Leu Asp Ile  Arg Val Glu 
    3785                 3790                 3795             


Ile Asp  Ser Gly Lys Cys Val  Leu His Pro Thr Thr  Leu Leu Gln 
    3800                 3805                 3810             


Glu His  Asp Asp Ile Ser Leu  Arg Arg Ser Tyr Asp  Arg Ser Ser 
    3815                 3820                 3825             


Arg Ser  Leu Asp Gln Asp Ser  Pro Ser Lys Lys Lys  Lys Phe Gln 
    3830                 3835                 3840             


Thr Asn  Tyr Ala Ser Thr Thr  His Leu Met Thr Gly  Lys Lys Val 
    3845                 3850                 3855             


Pro Ser  Ser Leu Gln Thr Lys  Pro Ser Asp Leu Glu  Thr Thr Val 
    3860                 3865                 3870             


Phe Tyr  Ile Pro Gly Val Asp  Val Lys Leu His Tyr  Asn Ser Lys 
    3875                 3880                 3885             


Thr Leu  Lys Thr Glu Ser Pro  Asn Ala Ser Arg Gly  Ser Ser Leu 
    3890                 3895                 3900             


Pro Arg  Thr Leu Ser Lys Glu  Ser Lys Leu Tyr Gly  Met Lys Asp 
    3905                 3910                 3915             


Ser Ala  Thr Ser Pro Pro Ser  Pro Pro Leu Pro Ser  Thr Val Gln 
    3920                 3925                 3930             


Ser Lys  Thr Asn Thr Leu Leu  Pro Pro Gln Pro Pro  Pro Ile Pro 
    3935                 3940                 3945             


Ala Ala  Lys Gly Lys Gly Ser  Gly Gly Val Lys Thr  Ala Lys Leu 
    3950                 3955                 3960             


Tyr Ala  Trp Val Ala Leu Gln  Ser Leu Pro Glu Glu  Met Val Ile 
    3965                 3970                 3975             


Ser Pro  Cys Leu Leu Asp Phe  Leu Glu Lys Ala Leu  Glu Thr Ile 
    3980                 3985                 3990             


Pro Ile  Thr Pro Val Glu Arg  Asn Tyr Thr Ala Val  Ser Ser Gln 
    3995                 4000                 4005             


Asp Glu  Asp Met Gly His Phe  Glu Ile Pro Asp Pro  Met Glu Glu 
    4010                 4015                 4020             


Ser Thr  Thr Ser Leu Val Ser  Ser Ser Thr Ser Ala  Tyr Ser Ser 
    4025                 4030                 4035             


Phe Pro  Val Asp Val Val Val  Tyr Val Arg Val Gln  Pro Ser Gln 
    4040                 4045                 4050             


Ile Lys  Phe Ser Cys Leu Pro  Val Ser Arg Val Glu  Cys Met Leu 
    4055                 4060                 4065             


Lys Leu  Pro Ser Leu Asp Leu  Val Phe Ser Ser Asn  Arg Gly Glu 
    4070                 4075                 4080             


Leu Glu  Thr Leu Gly Thr Thr  Tyr Pro Ala Glu Thr  Leu Ser Pro 
    4085                 4090                 4095             


Gly Gly  Asn Ala Thr Gln Ser  Gly Thr Lys Thr Ser  Ala Ser Lys 
    4100                 4105                 4110             


Thr Gly  Ile Pro Gly Ser Ser  Gly Leu Gly Ser Pro  Leu Gly Arg 
    4115                 4120                 4125             


Ser Arg  His Ser Ser Ser Gln  Ser Asp Leu Thr Ser  Ser Ser Ser 
    4130                 4135                 4140             


Ser Ser  Ser Gly Leu Ser Phe  Thr Ala Cys Met Ser  Asp Phe Ser 
    4145                 4150                 4155             


Leu Tyr  Val Phe His Pro Tyr  Gly Ala Gly Lys Gln  Lys Thr Ala 
    4160                 4165                 4170             


Val Ser  Gly Leu Thr Pro Gly  Ser Gly Gly Leu Gly  Asn Val Asp 
    4175                 4180                 4185             


Glu Glu  Pro Thr Ser Val Thr  Gly Arg Lys Asp Ser  Leu Ser Ile 
    4190                 4195                 4200             


Asn Leu  Glu Phe Val Lys Val  Ser Leu Ser Arg Ile  Arg Arg Ser 
    4205                 4210                 4215             


Gly Gly  Ala Ser Phe Phe Glu  Ser Gln Ser Val Ser  Lys Ser Ala 
    4220                 4225                 4230             


Ser Lys  Met Asp Thr Thr Leu  Ile Asn Ile Ser Ala  Val Cys Asp 
    4235                 4240                 4245             


Ile Gly  Ser Ala Ser Phe Lys  Tyr Asp Met Arg Arg  Leu Ser Glu 
    4250                 4255                 4260             


Ile Leu  Ala Phe Pro Arg Ala  Trp Tyr Arg Arg Ser  Ile Ala Arg 
    4265                 4270                 4275             


Arg Leu  Phe Leu Gly Asp Gln  Thr Ile Asn Leu Pro  Thr Ser Gly 
    4280                 4285                 4290             


Pro Gly  Thr Pro Asp Ser Ile  Glu Gly Val Ser Gln  His Leu Ser 
    4295                 4300                 4305             


Pro Glu  Ser Ser Arg Lys Ala  Tyr Cys Lys Thr Trp  Glu Gln Pro 
    4310                 4315                 4320             


Ser Gln  Ser Ala Ser Phe Thr  His Met Pro Gln Ser  Pro Asn Val 
    4325                 4330                 4335             


Phe Asn  Glu His Met Thr Asn  Ser Thr Met Ser Pro  Gly Thr Val 
    4340                 4345                 4350             


Gly Gln  Ser Leu Lys Ser Pro  Ala Ser Ile Arg Ser  Arg Ser Val 
    4355                 4360                 4365             


Ser Asp  Ser Ser Val Pro Arg  Arg Asp Ser Leu Ser  Lys Thr Ser 
    4370                 4375                 4380             


Thr Pro  Phe Asn Lys Ser Asn  Lys Ala Ala Ser Gln  Gln Gly Thr 
    4385                 4390                 4395             


Pro Trp  Glu Thr Leu Val Val  Phe Ala Ile Asn Leu  Lys Gln Leu 
    4400                 4405                 4410             


Asn Val  Gln Met Asn Met Ser  Asn Val Met Gly Asn  Thr Thr Trp 
    4415                 4420                 4425             


Thr Thr  Ser Gly Leu Lys Ser  Gln Gly Arg Leu Ser  Val Gly Ser 
    4430                 4435                 4440             


Asn Arg  Asp Arg Glu Ile Ser  Met Ser Val Gly Leu  Gly Arg Ser 
    4445                 4450                 4455             


Gln Leu  Asp Ser Lys Gly Gly  Val Val Gly Gly Thr  Ile Asp Val 
    4460                 4465                 4470             


Asn Ala  Leu Glu Met Val Ala  His Ile Ser Glu His  Pro Asn Gln 
    4475                 4480                 4485             


Gln Pro  Ser His Lys Ile Gln  Ile Thr Met Gly Ser  Thr Glu Ala 
    4490                 4495                 4500             


Arg Val  Asp Tyr Met Gly Ser  Ser Ile Leu Met Gly  Ile Phe Ser 
    4505                 4510                 4515             


Asn Ala  Asp Leu Lys Leu Gln  Asp Glu Trp Lys Val  Asn Leu Tyr 
    4520                 4525                 4530             


Asn Thr  Leu Asp Ser Ser Ile  Thr Asp Lys Ser Glu  Ile Phe Val 
    4535                 4540                 4545             


His Gly  Asp Leu Lys Trp Asp  Ile Phe Gln Val Met  Ile Ser Arg 
    4550                 4555                 4560             


Ser Thr  Thr Pro Asp Leu Ile  Lys Ile Gly Met Lys  Leu Gln Glu 
    4565                 4570                 4575             


Phe Phe  Thr Gln Gln Phe Asp  Thr Ser Lys Arg Ala  Leu Ser Thr 
    4580                 4585                 4590             


Trp Gly  Pro Val Pro Tyr Leu  Pro Pro Lys Thr Met  Thr Ser Asn 
    4595                 4600                 4605             


Leu Glu  Lys Ser Ser Gln Glu  Gln Leu Leu Asp Ala  Ala His His 
    4610                 4615                 4620             


Arg His  Trp Pro Gly Val Leu  Lys Val Val Ser Gly  Cys His Ile 
    4625                 4630                 4635             


Ser Leu  Phe Gln Ile Pro Leu  Pro Glu Asp Gly Met  Gln Phe Gly 
    4640                 4645                 4650             


Gly Ser  Met Ser Leu His Gly  Asn His Met Thr Leu  Ala Cys Phe 
    4655                 4660                 4665             


His Gly  Pro Asn Phe Arg Ser  Lys Ser Trp Ala Leu  Phe His Leu 
    4670                 4675                 4680             


Glu Glu  Pro Asn Ile Ala Phe  Trp Thr Glu Ala Gln  Lys Ile Trp 
    4685                 4690                 4695             


Glu Asp  Gly Ser Ser Asp His  Ser Thr Tyr Ile Val  Gln Thr Leu 
    4700                 4705                 4710             


Asp Phe  His Leu Gly His Asn  Thr Met Val Thr Lys  Pro Cys Gly 
    4715                 4720                 4725             


Ala Leu  Glu Ser Pro Met Ala  Thr Ile Thr Lys Ile  Thr Arg Arg 
    4730                 4735                 4740             


Arg His  Glu Asn Pro Pro His  Gly Val Ala Ser Val  Lys Glu Trp 
    4745                 4750                 4755             


Phe Asn  Tyr Val Thr Ala Thr  Arg Asn Glu Glu Leu  Asn Leu Leu 
    4760                 4765                 4770             


Arg Asn  Val Asp Ala Asn Asn  Thr Glu Asn Ser Thr  Thr Val Lys 
    4775                 4780                 4785             


Asn Ser  Ser Leu Leu Ser Gly  Phe Arg Gly Gly Ser  Ser Tyr Asn 
    4790                 4795                 4800             


His Glu  Thr Glu Thr Ile Phe  Ala Leu Pro Arg Met  Gln Leu Asp 
    4805                 4810                 4815             


Phe Lys  Ser Ile His Val Gln  Glu Pro Gln Glu Pro  Ser Leu Gln 
    4820                 4825                 4830             


Asp Ala  Ser Leu Lys Pro Lys  Val Glu Cys Ser Val  Val Thr Glu 
    4835                 4840                 4845             


Phe Thr  Asp His Ile Cys Val  Thr Met Asp Ala Glu  Leu Ile Met 
    4850                 4855                 4860             


Phe Leu  His Asp Leu Val Ser  Ala Tyr Leu Lys Glu  Lys Glu Lys 
    4865                 4870                 4875             


Ala Ile  Phe Pro Pro Arg Ile  Leu Ser Thr Arg Pro  Gly Gln Lys 
    4880                 4885                 4890             


Ser Pro  Ile Ile Ile His Asp  Asp Asn Ser Ser Asp  Lys Asp Arg 
    4895                 4900                 4905             


Glu Asp  Ser Ile Thr Tyr Thr  Thr Val Asp Trp Arg  Asp Phe Met 
    4910                 4915                 4920             


Cys Asn  Thr Trp His Leu Glu  Pro Thr Leu Arg Leu  Ile Ser Trp 
    4925                 4930                 4935             


Thr Gly  Arg Lys Ile Asp Pro  Val Gly Val Asp Tyr  Ile Leu Gln 
    4940                 4945                 4950             


Lys Leu  Gly Phe His His Ala  Arg Thr Thr Ile Pro  Lys Trp Leu 
    4955                 4960                 4965             


Gln Arg  Gly Val Met Asp Pro  Leu Asp Lys Val Leu  Ser Val Leu 
    4970                 4975                 4980             


Ile Lys  Lys Leu Gly Thr Ala  Leu Gln Asp Glu Lys  Glu Lys Lys 
    4985                 4990                 4995             


Gly Lys  Asp Lys Glu Glu His  
    5000                 5005 


<210>  5846
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1147__Homo_sapiens__NP_001073861

<400>  5846

Met Val Glu Gln Gly Asp Ala Ala Pro Leu Leu Arg Trp Ala Glu Gly 
1               5                   10                  15      


Pro Ala Val Ser Leu Pro Gln Ala Pro Gln Pro Gln Ala Gly Gly Trp 
            20                  25                  30          


Gly Arg Gly Gly Gly Gly Gly Ala Arg Pro Ala Ala Glu Pro Pro Arg 
        35                  40                  45              


Arg Arg Glu Pro Glu Glu Pro Ala Ala Pro Glu Val Leu Leu Gln Pro 
    50                  55                  60                  


Gly Arg Leu Glu Leu Gly Asp Val Glu Glu Asp Gln Val Val Ala Val 
65                  70                  75                  80  


Phe Val Val Thr Phe Asp Pro Arg Ser Gly Asn Met Val Glu Trp Cys 
                85                  90                  95      


Leu Pro Gln Asp Ile Asp Leu Glu Gly Val Glu Phe Lys Ser Met Ala 
            100                 105                 110         


Ser Gly Ser His Lys Ile Gln Ser Asp Phe Ile Tyr Phe Arg Lys Gly 
        115                 120                 125             


Pro Phe Phe Gly Leu Ala Cys Phe Ala Asn Met Pro Val Glu Ser Glu 
    130                 135                 140                 


Leu Glu Arg Gly Ala Arg Met Lys Ser Val Gly Ile Leu Ser Pro Ser 
145                 150                 155                 160 


Tyr Thr Leu Leu Tyr Arg Tyr Met His Phe Leu Glu Asn Gln Val Arg 
                165                 170                 175     


His Gln Leu Glu Met Pro Gly His Tyr Ser His Leu Ala Ala Phe Tyr 
            180                 185                 190         


Glu Asp Lys Lys Gly Val Leu His Ala Gly Pro Gly Arg Gly Ser Ser 
        195                 200                 205             


Leu Pro Pro Val Tyr Trp Leu Pro Ser Ile His Arg Tyr Met Tyr Pro 
    210                 215                 220                 


Glu Met Lys Ile Thr His Pro Ala Gly Cys Met Ser Gln Phe Ile Lys 
225                 230                 235                 240 


Phe Phe Gly Glu Gln Ile Leu Ile Leu Trp Lys Phe Ala Leu Leu Arg 
                245                 250                 255     


Lys Arg Ile Leu Ile Phe Ser Pro Pro Pro Val Gly Val Val Cys Tyr 
            260                 265                 270         


Arg Val Tyr Cys Cys Cys Cys Leu Ala Asn Val Ser Leu Pro Gly Ile 
        275                 280                 285             


Gly Gly Thr Ile Pro Glu Ser Lys Pro Phe Phe Tyr Val Asn Val Ala 
    290                 295                 300                 


Asp Ile Glu Ser Leu Glu Val Glu Val Ser Tyr Val Ala Cys Thr Thr 
305                 310                 315                 320 


Glu Lys Ile Phe Glu Glu Lys Arg Glu Leu Tyr Asp Val Tyr Val Asp 
                325                 330                 335     


Asn Gln Asn Val Lys Thr His His Asp His Leu Gln Pro Leu Leu Lys 
            340                 345                 350         


Ile Asn Ser Ala Asp Arg Glu Lys Tyr Arg Arg Leu Asn Glu Gln Arg 
        355                 360                 365             


Gln Met Leu Leu Tyr Ser Gln Glu Val Glu Glu Asp Tyr Asn Pro Cys 
    370                 375                 380                 


Glu Glu Asp Leu Phe Val Leu Phe Phe Leu Glu Gln Asn Asn Arg Ile 
385                 390                 395                 400 


Phe Gln Thr Leu Leu Glu Val Ser Ala Ser Gln Asp Lys Thr Leu Thr 
                405                 410                 415     


Ala Glu His Ala Arg Gly Met Gly Leu Asp Pro Gln Gly Asp Arg Ser 
            420                 425                 430         


Phe Leu Leu Asp Leu Leu Glu Ala Tyr Gly Ile Asp Val Met Leu Val 
        435                 440                 445             


Ile Asp Asn Pro Cys Cys Pro 
    450                 455 


<210>  5847
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1161__Homo_sapiens__NP_065753

<400>  5847

Met Leu Gln Asn Pro Gln Glu Lys Ser Gln Ala Tyr Pro Arg Arg Arg 
1               5                   10                  15      


Arg Pro Gly Cys Tyr Ala Tyr Arg Gln Asn Pro Glu Ala Ile Ala Ala 
            20                  25                  30          


Ala Ala Met Tyr Thr Phe Leu Pro Asp Asn Phe Ser Pro Ala Lys Pro 
        35                  40                  45              


Lys Pro Ser Lys Asp Leu Lys Pro Leu Leu Gly Ser Ala Val Leu Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Ala Ala Val Val Ala Trp Cys Tyr Tyr Ser Val 
65                  70                  75                  80  


Ser Leu Arg Lys Ala Glu Arg Leu Arg Ala Glu Leu Leu Asp Leu Lys 
                85                  90                  95      


Ala Gly Gly Phe Ser Ile Arg Asn Gln Lys Gly Glu Gln Val Phe Arg 
            100                 105                 110         


Leu Ala Phe Arg Ser Gly Ala Leu Asp Leu Asp Ser Cys Ser Arg Asp 
        115                 120                 125             


Gly Ala Leu Leu Gly Cys Ser Leu Thr Ala Asp Gly Leu Pro Leu His 
    130                 135                 140                 


Phe Phe Ile Gln Thr Val Arg Pro Lys Asp Thr Val Met Cys Tyr Arg 
145                 150                 155                 160 


Val Arg Trp Glu Glu Ala Ala Pro Gly Arg Ala Val Glu His Ala Met 
                165                 170                 175     


Phe Leu Gly Asp Ala Ala Ala His Trp Tyr Gly Gly Ala Glu Met Arg 
            180                 185                 190         


Thr Gln His Trp Pro Ile Arg Leu Asp Gly Gln Gln Glu Pro Gln Pro 
        195                 200                 205             


Phe Val Thr Ser Asp Val Tyr Ser Ser Asp Ala Ala Phe Gly Gly Ile 
    210                 215                 220                 


Leu Glu Arg Tyr Trp Leu Ser Ser Arg Ala Ala Ala Ile Lys Val Asn 
225                 230                 235                 240 


Asp Ser Val Pro Phe His Leu Gly Trp Asn Ser Thr Glu Arg Ser Leu 
                245                 250                 255     


Arg Leu Gln Ala Arg Tyr His Asp Thr Pro Tyr Lys Pro Pro Ala Gly 
            260                 265                 270         


Arg Ala Ala Ala Pro Glu Leu Ser Tyr Arg Val Cys Val Gly Ser Asp 
        275                 280                 285             


Val Thr Ser Ile His Lys Tyr Met Val Arg Arg Tyr Phe Asn Lys Pro 
    290                 295                 300                 


Ser Arg Val Pro Ala Pro Glu Ala Phe Arg Asp Pro Ile Trp Ser Thr 
305                 310                 315                 320 


Trp Ala Leu Tyr Gly Arg Ala Val Asp Gln Asp Lys Val Leu Arg Phe 
                325                 330                 335     


Ala Gln Gln Ile Arg Leu His His Phe Asn Ser Ser His Leu Glu Ile 
            340                 345                 350         


Asp Asp Met Tyr Thr Pro Ala Tyr Gly Asp Phe Asp Phe Asp Glu Val 
        355                 360                 365             


Lys Phe Pro Asn Ala Ser Asp Met Phe Arg Arg Leu Arg Asp Ala Gly 
    370                 375                 380                 


Phe Arg Val Thr Leu Trp Val His Pro Phe Val Asn Tyr Asn Ser Ser 
385                 390                 395                 400 


Arg Phe Gly Glu Gly Val Glu Arg Glu Leu Phe Val Arg Glu Pro Thr 
                405                 410                 415     


Gly Arg Leu Pro Ala Leu Val Arg Trp Trp Asn Gly Ile Gly Ala Val 
            420                 425                 430         


Leu Asp Phe Thr His Pro Lys Ala Arg Asp Trp Phe Gln Gly His Leu 
        435                 440                 445             


Arg Arg Leu Arg Ser Arg Tyr Ser Val Ala Ser Phe Lys Phe Asp Ala 
    450                 455                 460                 


Gly Glu Val Ser Tyr Leu Pro Arg Asp Phe Ser Thr Tyr Arg Pro Leu 
465                 470                 475                 480 


Pro Asp Pro Ser Val Trp Ser Arg Arg Tyr Thr Glu Met Ala Leu Pro 
                485                 490                 495     


Phe Phe Ser Leu Ala Glu Val Arg Val Gly Tyr Gln Ser Gln Asn Ile 
            500                 505                 510         


Ser Cys Phe Phe Arg Leu Val Asp Arg Asp Ser Val Trp Gly Tyr Asp 
        515                 520                 525             


Leu Gly Leu Arg Ser Leu Ile Pro Ala Val Leu Thr Val Ser Met Leu 
    530                 535                 540                 


Gly Tyr Pro Phe Ile Leu Pro Asp Met Val Gly Gly Asn Ala Val Pro 
545                 550                 555                 560 


Gln Arg Thr Ala Gly Gly Asp Val Pro Glu Arg Glu Leu Tyr Ile Arg 
                565                 570                 575     


Trp Leu Glu Val Ala Ala Phe Met Pro Ala Met Gln Phe Ser Ile Pro 
            580                 585                 590         


Pro Trp Arg Tyr Asp Ala Glu Val Val Ala Ile Ala Gln Lys Phe Ala 
        595                 600                 605             


Ala Leu Arg Ala Ser Leu Val Ala Pro Leu Leu Leu Glu Leu Ala Gly 
    610                 615                 620                 


Glu Val Thr Asp Thr Gly Asp Pro Ile Val Arg Pro Leu Trp Trp Ile 
625                 630                 635                 640 


Ala Pro Gly Asp Glu Thr Ala His Arg Ile Asp Ser Gln Phe Leu Ile 
                645                 650                 655     


Gly Asp Thr Leu Leu Val Ala Pro Val Leu Glu Pro Gly Lys Gln Glu 
            660                 665                 670         


Arg Asp Val Tyr Leu Pro Ala Gly Lys Trp Arg Ser Tyr Lys Gly Glu 
        675                 680                 685             


Leu Phe Asp Lys Thr Pro Val Leu Leu Thr Asp Tyr Pro Val Asp Leu 
    690                 695                 700                 


Asp Glu Ile Ala Tyr Phe Thr Trp Ala Ser 
705                 710                 


<210>  5848
<211>  1233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1211__Homo_sapiens__NP_065773

<400>  5848

Met Gly Thr Arg Ala Phe Ser His Asp Ser Ile Phe Ile Pro Asp Gly 
1               5                   10                  15      


Gly Ala Glu Ser Glu Gln Thr Val Gln Ala Met Ser Gln Asp Asn Ile 
            20                  25                  30          


Leu Gly Lys Val Lys Thr Leu Gln Gln Gln Leu Gly Lys Asn Ile Lys 
        35                  40                  45              


Phe Gly Gln Arg Ser Pro Asn Ala Ile Pro Met Asn Lys Ala Asn Ser 
    50                  55                  60                  


Gly Glu Ala Ser Leu Glu Glu Asp Leu Phe Leu Thr Ser Pro Met Glu 
65                  70                  75                  80  


Ile Val Thr Gln Gln Asp Ile Val Leu Ser Asp Ala Glu Asn Lys Ser 
                85                  90                  95      


Ser Asp Thr Pro Ser Ser Leu Ser Pro Leu Asn Leu Pro Gly Ala Gly 
            100                 105                 110         


Ser Glu Met Glu Glu Lys Val Ala Pro Val Lys Pro Ser Arg Pro Lys 
        115                 120                 125             


Arg His Phe Ser Ser Ala Gly Thr Ile Glu Ser Val Asn Leu Asp Ala 
    130                 135                 140                 


Ile Pro Leu Ala Ile Ala Arg Leu Asp Asn Ser Ala Ala Lys His Lys 
145                 150                 155                 160 


Leu Ala Val Lys Pro Lys Lys Gln Arg Val Ser Lys Lys His Arg Arg 
                165                 170                 175     


Leu Ala Gln Asp Pro Gln His Glu Gln Gly Gly Leu Glu Ser Arg Pro 
            180                 185                 190         


Cys Leu Asp Gln Asn Gly His Pro Gly Glu Asp Lys Pro Thr Trp His 
        195                 200                 205             


Glu Glu Glu Pro Asn Pro Leu Asp Ser Glu Glu Glu Arg Arg Arg Gln 
    210                 215                 220                 


Glu Asp Tyr Trp Arg Glu Leu Glu Ala Lys Cys Lys Arg Gln Lys Ala 
225                 230                 235                 240 


Glu Ala Ala Glu Lys Arg Arg Leu Glu Glu Gln Arg Leu Gln Ala Leu 
                245                 250                 255     


Glu Arg Arg Leu Trp Glu Glu Asn Arg Arg Gln Glu Leu Leu Glu Glu 
            260                 265                 270         


Glu Gly Glu Gly Gln Glu Pro Pro Leu Glu Ala Glu Arg Ala Pro Arg 
        275                 280                 285             


Glu Glu Gln Gln Arg Ser Leu Glu Ala Pro Gly Trp Glu Asp Ala Glu 
    290                 295                 300                 


Arg Arg Glu Arg Glu Glu Arg Glu Arg Leu Glu Ala Glu Glu Glu Arg 
305                 310                 315                 320 


Arg Arg Leu Gln Ala Gln Ala Gln Ala Glu Glu Arg Arg Arg Leu Glu 
                325                 330                 335     


Glu Asp Ala Arg Leu Glu Glu Arg Arg Arg Gln Glu Glu Glu Glu Gly 
            340                 345                 350         


Arg Cys Ala Glu Glu Leu Lys Arg Gln Glu Glu Glu Glu Ala Glu Gly 
        355                 360                 365             


Trp Glu Glu Leu Glu Gln Gln Glu Ala Glu Val Gln Gly Pro Pro Glu 
    370                 375                 380                 


Ala Leu Glu Glu Thr Gly Glu Gly Arg Arg Gly Ala Glu Glu Glu Asp 
385                 390                 395                 400 


Leu Gly Glu Glu Glu Glu Glu Gly Gln Ala His Leu Glu Asp Trp Arg 
                405                 410                 415     


Gly Gln Leu Ser Glu Leu Leu Asn Asp Phe Glu Glu Arg Leu Glu Asp 
            420                 425                 430         


Gln Glu Arg Leu Lys Pro Glu Gly Gln Arg Glu His Ser Glu Glu Pro 
        435                 440                 445             


Gly Ile Cys Glu Glu Gln Asn Pro Glu Ala Glu Arg Arg Arg Glu Gln 
    450                 455                 460                 


Gln Gly Arg Ser Gly Asp Phe Gln Gly Ala Asp Arg Pro Gly Pro Glu 
465                 470                 475                 480 


Glu Lys Arg Glu Glu Gly Asp Thr Glu Pro Leu Leu Lys Gln Glu Gly 
                485                 490                 495     


Pro Val Glu Ala Ala Gln Pro Pro Val Glu Arg Lys Glu Ala Ala Ala 
            500                 505                 510         


Leu Glu Gln Gly Arg Lys Val Glu Glu Leu Arg Trp Gln Glu Val Asp 
        515                 520                 525             


Glu Arg Gln Thr Met Pro Arg Pro Tyr Thr Phe Gln Val Ser Ser Gly 
    530                 535                 540                 


Gly Lys Gln Ile Leu Phe Pro Lys Val Asn Leu Ser Pro Val Thr Pro 
545                 550                 555                 560 


Ala Lys Asp Thr Gly Leu Thr Ala Ala Pro Gln Glu Pro Lys Ala Pro 
                565                 570                 575     


Lys Ala Ser Pro Val Gln His Ala Leu Pro Ser Ser Leu Ser Val Pro 
            580                 585                 590         


His Thr Ala Ile Leu Val Thr Gly Ala Gln Leu Cys Gly Pro Ala Val 
        595                 600                 605             


Asn Leu Ser Gln Ile Lys Asp Thr Ala Cys Lys Ser Leu Leu Gly Leu 
    610                 615                 620                 


Glu Glu Lys Lys His Ala Glu Ala Pro Ala Gly Glu Asn Pro Pro Arg 
625                 630                 635                 640 


Gly Pro Gly Asp Ala Arg Ala Gly Ser Gly Lys Ala Lys Pro Arg Gln 
                645                 650                 655     


Glu Ser Pro Ser Ser Ala Ser Ala Leu Ala Glu Trp Ala Ser Ile Arg 
            660                 665                 670         


Ser Arg Ile Leu Lys Asn Ala Glu Ser Asp Pro Arg Ser Ser Glu Arg 
        675                 680                 685             


Asp Gln Leu Arg Pro Gly Asp Glu Ser Thr Pro Arg Gly Arg Cys Asp 
    690                 695                 700                 


Ser Arg Gly Asn Gln Arg Lys Thr Pro Pro Val Asn Ala Lys Phe Ser 
705                 710                 715                 720 


Ile Met Pro Ala Trp Gln Lys Phe Ser Asp Gly Gly Thr Glu Thr Ser 
                725                 730                 735     


Lys Gln Ser Thr Glu Ala Glu Ser Ile Arg Lys Arg Pro Met Leu Gly 
            740                 745                 750         


Pro Ser Glu Glu Thr Ala Pro Gln Pro Pro Pro Ala Gly Val Arg Glu 
        755                 760                 765             


Leu Gly Lys Gly Pro Glu Lys Ser Glu Met His Arg Glu Pro Ala Asp 
    770                 775                 780                 


Thr Thr Glu Gly Cys Lys Phe Ala Lys Asp Leu Pro Ser Phe Leu Val 
785                 790                 795                 800 


Pro Ser Leu Pro Tyr Pro Pro Gln Lys Val Val Ala His Thr Glu Phe 
                805                 810                 815     


Thr Thr Ser Ser Asp Ser Glu Thr Ala Asn Gly Ile Ala Lys Pro Asp 
            820                 825                 830         


Pro Val Met Pro Gly Gly Glu Glu Lys Ala Ser Pro Phe Gly Ile Lys 
        835                 840                 845             


Leu Arg Arg Thr Asn Tyr Ser Leu Arg Phe Asn Cys Asp Gln Gln Ala 
    850                 855                 860                 


Glu Gln Lys Lys Lys Lys Arg His Ser Ser Thr Gly Asp Ser Ala Asp 
865                 870                 875                 880 


Ala Gly Pro Pro Ala Ala Gly Ser Ala Arg Gly Glu Lys Glu Met Glu 
                885                 890                 895     


Gly Val Ala Leu Lys His Gly Pro Ser Leu Pro Gln Glu Arg Lys Gln 
            900                 905                 910         


Ala Pro Ser Thr Arg Arg Asp Ser Ala Glu Pro Ser Ser Ser Arg Ser 
        915                 920                 925             


Val Pro Val Ala His Pro Gly Pro Pro Pro Ala Ser Ser Gln Thr Pro 
    930                 935                 940                 


Ala Pro Glu His Asp Lys Ala Ala Asn Lys Met Pro Leu Ala Gln Lys 
945                 950                 955                 960 


Pro Ala Leu Ala Pro Lys Pro Thr Ser Gln Thr Pro Pro Ala Ser Pro 
                965                 970                 975     


Leu Ser Lys Leu Ser Arg Pro Tyr Leu Val Glu Leu Leu Ser Arg Arg 
            980                 985                 990         


Ala Gly Arg Pro Asp Pro Glu Pro  Ser Glu Pro Ser Lys  Glu Asp Gln 
        995                 1000                 1005             


Glu Ser  Ser Asp Arg Arg Pro  Pro Ser Pro Pro Gly  Pro Glu Glu 
    1010                 1015                 1020             


Arg Lys  Gly Gln Lys Arg Asp  Glu Glu Glu Glu Ala  Thr Glu Arg 
    1025                 1030                 1035             


Lys Pro  Ala Ser Pro Pro Leu  Pro Ala Thr Gln Gln  Glu Lys Pro 
    1040                 1045                 1050             


Ser Gln  Thr Pro Glu Ala Gly  Arg Lys Glu Lys Pro  Met Leu Gln 
    1055                 1060                 1065             


Ser Arg  His Ser Leu Asp Gly  Ser Lys Leu Thr Glu  Lys Val Glu 
    1070                 1075                 1080             


Thr Ala  Gln Pro Leu Trp Ile  Thr Leu Ala Leu Gln  Lys Gln Lys 
    1085                 1090                 1095             


Gly Phe  Arg Glu Gln Gln Ala  Thr Arg Glu Glu Arg  Lys Gln Ala 
    1100                 1105                 1110             


Arg Glu  Ala Lys Gln Ala Glu  Lys Leu Ser Lys Glu  Asn Val Ser 
    1115                 1120                 1125             


Val Ser  Val Gln Pro Gly Ser  Ser Ser Val Ser Arg  Ala Gly Ser 
    1130                 1135                 1140             


Leu His  Lys Ser Thr Ala Leu  Pro Glu Glu Lys Arg  Pro Glu Thr 
    1145                 1150                 1155             


Ala Val  Ser Arg Leu Glu Arg  Arg Glu Gln Leu Lys  Lys Ala Asn 
    1160                 1165                 1170             


Thr Leu  Pro Thr Ser Val Thr  Val Glu Ile Ser Asp  Ser Ala Pro 
    1175                 1180                 1185             


Pro Ala  Pro Leu Val Lys Glu  Val Thr Lys Arg Phe  Ser Thr Pro 
    1190                 1195                 1200             


Asp Ala  Ala Pro Val Ser Thr  Glu Pro Ala Trp Leu  Ala Leu Ala 
    1205                 1210                 1215             


Lys Arg  Lys Ala Lys Ala Trp  Ser Asp Cys Pro Gln  Ile Ile Lys 
    1220                 1225                 1230             


<210>  5849
<211>  990
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1211L__Homo_sapiens__XP_005263981

<400>  5849

Met Arg Glu Leu Glu Ala His Ser Thr Leu Arg Arg Met Ala Ala Phe 
1               5                   10                  15      


Tyr Gln Cys Ile Arg Pro Asp Pro Ser Glu Leu Asp Met Ile Ser Thr 
            20                  25                  30          


Arg Val Met Asp Ile Lys Leu Arg Glu Ala Ala Glu Gly Leu Gly Glu 
        35                  40                  45              


Asp Ser Thr Gly Lys Lys Lys Ser Lys Phe Lys Thr Phe Lys Lys Phe 
    50                  55                  60                  


Phe Gly Lys Lys Lys Arg Lys Glu Ser Pro Ser Ser Thr Gly Ser Ser 
65                  70                  75                  80  


Thr Trp Lys Gln Ser Gln Thr Arg Asn Glu Val Ile Ala Ile Glu Ser 
                85                  90                  95      


Gly Pro Val Gly Tyr Asp Ser Glu Asp Glu Leu Glu Glu Ser Arg Gly 
            100                 105                 110         


Thr Leu Gly Ser Arg Ala Leu Ser His Asp Ser Ile Phe Ile Pro Glu 
        115                 120                 125             


Ser Gly Gln Asp Ala Thr Arg Pro Val Arg Val Phe Ser Gln Glu Asn 
    130                 135                 140                 


Val Cys Asp Arg Ile Lys Ala Leu Gln Leu Lys Ile Gln Cys Asn Val 
145                 150                 155                 160 


Lys Met Gly Pro Pro Pro Pro Pro Gly Gly Leu Pro Ala Lys Arg Gly 
                165                 170                 175     


Glu Asp Ala Gly Met Ser Ser Glu Asp Asp Gly Leu Pro Arg Ser Pro 
            180                 185                 190         


Pro Glu Met Ser Leu Leu His Asp Val Gly Pro Gly Thr Thr Ile Lys 
        195                 200                 205             


Val Ser Val Val Ser Pro Asp His Val Ser Asp Ser Thr Val Ser Ala 
    210                 215                 220                 


Arg Ile Ser Asp Asn Ser Leu Ala Pro Val Ala Asp Phe Ser Tyr Pro 
225                 230                 235                 240 


Ala Glu Ser Ser Ser Cys Leu Asp Asn Ser Ala Ala Lys His Lys Leu 
                245                 250                 255     


Gln Val Lys Pro Arg Asn Gln Arg Ser Ser Lys Met Arg Arg Leu Ser 
            260                 265                 270         


Ser Arg Ala Gln Ser Glu Ser Leu Ser Asp Leu Thr Cys Thr Pro Glu 
        275                 280                 285             


Glu Glu Glu Asn Glu Glu Lys Pro Leu Leu Glu Val Ser Pro Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Gly Gln Gln Asp Val Ala Pro Asp Arg Gly Pro Glu 
305                 310                 315                 320 


Pro Gly Pro Pro Ala Pro Leu Pro Pro Pro Gly Gly Ala Arg Ala Arg 
                325                 330                 335     


Arg Ala Arg Leu Gln His Ser Ser Ala Leu Thr Ala Ser Val Glu Glu 
            340                 345                 350         


Gly Gly Val Pro Gly Glu Asp Pro Ser Ser Arg Pro Ala Thr Pro Glu 
        355                 360                 365             


Leu Ala Glu Pro Glu Ser Ala Pro Thr Leu Arg Val Glu Pro Pro Ser 
    370                 375                 380                 


Pro Pro Glu Gly Pro Pro Asn Pro Gly Pro Asp Gly Gly Lys Gln Asp 
385                 390                 395                 400 


Gly Glu Ala Pro Pro Ala Gly Pro Cys Ala Pro Ala Thr Asp Lys Ala 
                405                 410                 415     


Glu Glu Val Val Cys Ala Pro Glu Asp Val Ala Ser Pro Phe Pro Thr 
            420                 425                 430         


Ala Ile Pro Glu Gly Asp Thr Thr Pro Pro Glu Thr Asp Pro Ala Ala 
        435                 440                 445             


Thr Ser Glu Ala Pro Ser Ala Arg Asp Gly Pro Glu Arg Ser Val Pro 
    450                 455                 460                 


Lys Glu Ala Glu Pro Thr Pro Pro Val Leu Pro Asp Glu Glu Lys Gly 
465                 470                 475                 480 


Pro Pro Gly Pro Ala Pro Glu Pro Glu Arg Glu Ala Glu Thr Glu Pro 
                485                 490                 495     


Glu Arg Gly Ala Gly Thr Glu Pro Glu Arg Ile Gly Thr Glu Pro Ser 
            500                 505                 510         


Thr Ala Pro Ala Pro Ser Pro Pro Ala Pro Lys Ser Cys Leu Lys His 
        515                 520                 525             


Arg Pro Ala Ala Ala Ser Glu Gly Pro Ala Ala Ser Pro Pro Leu Ala 
    530                 535                 540                 


Ala Ala Glu Ser Pro Pro Val Glu Pro Gly Pro Gly Ser Leu Asp Ala 
545                 550                 555                 560 


Glu Ala Ala Ala Pro Glu Arg Pro Lys Ala Glu Arg Ala Glu Ala Pro 
                565                 570                 575     


Pro Ala Gly Ala Glu Arg Ala Ala Pro Glu Arg Lys Ala Glu Arg Gly 
            580                 585                 590         


Gly Ala Glu Leu Arg Gly Ala Lys Lys Phe Ser Val Ser Ser Cys Arg 
        595                 600                 605             


Ala Arg Pro Arg Pro Gly Val Ser Arg Pro Leu Glu Arg Ala Ser Gly 
    610                 615                 620                 


Arg Leu Pro Leu Ala Arg Ser Gly Pro Val Trp Arg Ser Glu Ala Ala 
625                 630                 635                 640 


Leu Asp Asp Leu Gln Gly Leu Pro Glu Pro Gln His Ala Lys Pro Gly 
                645                 650                 655     


Pro Arg Lys Leu Ala Glu Arg Gly Pro Gln Asp Ser Gly Asp Arg Ala 
            660                 665                 670         


Ala Ser Pro Ala Gly Pro Arg Lys Ser Pro Gln Glu Ala Ala Ala Ala 
        675                 680                 685             


Pro Gly Thr Arg Glu Pro Cys Pro Ala Ala Gln Glu Pro Ala Pro Ser 
    690                 695                 700                 


Glu Asp Arg Asn Pro Phe Pro Val Lys Leu Arg Ser Thr Ser Leu Ser 
705                 710                 715                 720 


Leu Lys Tyr Arg Asp Gly Ala Ser Gln Glu Val Lys Gly Val Lys Arg 
                725                 730                 735     


Tyr Ser Ala Glu Val Arg Leu Glu Arg Ser Leu Thr Val Leu Pro Lys 
            740                 745                 750         


Glu Glu Lys Cys Pro Leu Gly Thr Ala Pro Ala Leu Arg Gly Thr Arg 
        755                 760                 765             


Ala Pro Ser Asp Gln Gly Lys Gly Lys Ala Arg Pro Pro Glu Pro Leu 
    770                 775                 780                 


Ser Ser Lys Pro Pro Leu Pro Arg Lys Pro Leu Leu Gln Ser Phe Thr 
785                 790                 795                 800 


Leu Pro His Gln Pro Ala Pro Pro Asp Ala Gly Pro Gly Glu Arg Glu 
                805                 810                 815     


Pro Arg Lys Glu Pro Arg Thr Ala Glu Lys Arg Pro Leu Arg Arg Gly 
            820                 825                 830         


Ala Glu Lys Ser Leu Pro Pro Ala Ala Thr Gly Pro Gly Ala Asp Gly 
        835                 840                 845             


Gln Pro Ala Pro Pro Trp Ile Thr Val Thr Arg Gln Lys Arg Arg Gly 
    850                 855                 860                 


Thr Leu Asp Gln Pro Pro Asn Gln Glu Asp Lys Pro Gly Ala Arg Thr 
865                 870                 875                 880 


Leu Lys Ser Glu Pro Gly Lys Gln Ala Lys Val Pro Glu Arg Gly Gln 
                885                 890                 895     


Glu Pro Val Lys Gln Ala Asp Phe Val Arg Ser Lys Ser Phe Leu Ile 
            900                 905                 910         


Thr Pro Val Lys Pro Ala Val Asp Arg Lys Gln Gly Ala Lys Leu Asn 
        915                 920                 925             


Phe Lys Glu Gly Leu Gln Arg Gly Ile Ser Leu Ser His Gln Asn Leu 
    930                 935                 940                 


Ala Gln Ser Ala Val Met Met Glu Lys Glu Leu His Gln Leu Lys Arg 
945                 950                 955                 960 


Ala Ser Tyr Ala Ser Thr Asp Gln Pro Ser Trp Met Glu Leu Ala Arg 
                965                 970                 975     


Lys Lys Ser Gln Ala Trp Ser Asp Met Pro Gln Ile Ile Lys 
            980                 985                 990 


<210>  5850
<211>  1264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1217__Homo_sapiens__NP_001091970

<400>  5850

Met Gln Thr Ser Glu Met Asp Arg Lys Arg Glu Ala Phe Leu Glu His 
1               5                   10                  15      


Leu Lys Gln Lys Tyr Pro His His Ala Ser Ala Ile Met Gly His Gln 
            20                  25                  30          


Glu Arg Leu Arg Asp Gln Thr Arg Ser Pro Lys Leu Ser His Ser Pro 
        35                  40                  45              


Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr Ser 
    50                  55                  60                  


Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro Phe 
65                  70                  75                  80  


Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser Thr 
                85                  90                  95      


Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr Gly 
            100                 105                 110         


Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala Asp 
        115                 120                 125             


Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met 
    130                 135                 140                 


Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser 
145                 150                 155                 160 


Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg 
                165                 170                 175     


Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His 
            180                 185                 190         


Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val 
        195                 200                 205             


Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala 
    210                 215                 220                 


His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro 
225                 230                 235                 240 


His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg 
                245                 250                 255     


Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser 
            260                 265                 270         


Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu 
        275                 280                 285             


Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile 
    290                 295                 300                 


Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His 
305                 310                 315                 320 


Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp 
                325                 330                 335     


Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala 
            340                 345                 350         


Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln 
        355                 360                 365             


Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro 
    370                 375                 380                 


Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp 
385                 390                 395                 400 


Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro 
                405                 410                 415     


His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys 
            420                 425                 430         


Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala 
        435                 440                 445             


Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln 
    450                 455                 460                 


Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Arg 
465                 470                 475                 480 


Glu Arg Met Gln Ala Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu 
                485                 490                 495     


Val Gln Ser Ala Leu Phe Lys Gly Pro Ile Thr Ser Tyr Ser Lys Asp 
            500                 505                 510         


Ala Ser Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr 
        515                 520                 525             


Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala 
    530                 535                 540                 


Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser 
545                 550                 555                 560 


Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu 
                565                 570                 575     


Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu 
            580                 585                 590         


Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys 
        595                 600                 605             


Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg 
    610                 615                 620                 


Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys 
625                 630                 635                 640 


Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys 
                645                 650                 655     


Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu 
            660                 665                 670         


Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu 
        675                 680                 685             


Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg 
    690                 695                 700                 


Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu 
705                 710                 715                 720 


Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met 
                725                 730                 735     


Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala 
            740                 745                 750         


Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val 
        755                 760                 765             


Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His 
    770                 775                 780                 


Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser 
785                 790                 795                 800 


Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro 
                805                 810                 815     


Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His 
            820                 825                 830         


Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln 
        835                 840                 845             


Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala 
    850                 855                 860                 


Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn 
865                 870                 875                 880 


Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg 
                885                 890                 895     


Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu 
            900                 905                 910         


Glu Ala Gln Ala Asn Ile Met Lys Ser Ile Pro Asn Leu Glu Met Pro 
        915                 920                 925             


Pro Ala Thr Gly Pro Leu Pro Arg Gly Asp Ala Pro Val Asp Lys Val 
    930                 935                 940                 


Glu Leu Ser Glu Asp Ser Pro Asn Ser Glu Gln Asp Leu Glu Lys Leu 
945                 950                 955                 960 


Gly Gly Lys Ser Pro Pro Pro Pro Pro Pro Pro Pro Arg Arg Ser Tyr 
                965                 970                 975     


Leu Pro Gly Ser Gly Leu Thr Thr Thr Arg Ser Gly Asp Val Val Tyr 
            980                 985                 990         


Thr Gly Arg Lys Glu Asn Ile Thr  Ala Lys Ala Ser Ser  Glu Asp Ala 
        995                 1000                 1005             


Gly Pro  Ser Pro Gln Thr Arg  Ala Thr Lys Tyr Pro  Ala Glu Glu 
    1010                 1015                 1020             


Pro Ala  Ser Ala Trp Thr Pro  Ser Pro Pro Pro Val  Thr Thr Ser 
    1025                 1030                 1035             


Ser Ser  Lys Asp Glu Glu Glu  Glu Glu Glu Glu Gly  Asp Lys Ile 
    1040                 1045                 1050             


Met Ala  Glu Leu Gln Gly Ser  Ser Gly Ala Pro Gln  Thr Ser Arg 
    1055                 1060                 1065             


Met Pro  Val Pro Met Ser Ala  Lys Asn Arg Pro Gly  Thr Leu Asp 
    1070                 1075                 1080             


Lys Pro  Gly Lys Gln Ser Lys  Leu Gln Asp Pro Arg  Gln Tyr Arg 
    1085                 1090                 1095             


Gln Ala  Asn Gly Ser Ala Lys  Lys Ser Gly Gly Asp  Phe Lys Pro 
    1100                 1105                 1110             


Thr Ser  Pro Ser Leu Pro Ala  Ser Lys Ile Pro Ala  Leu Ser Pro 
    1115                 1120                 1125             


Ser Ser  Gly Lys Ser Ser Ser  Leu Pro Ser Ser Ser  Gly Asp Ser 
    1130                 1135                 1140             


Ser Asn  Leu Pro Asn Pro Pro  Ala Thr Lys Pro Ser  Ile Ala Ser 
    1145                 1150                 1155             


Asn Pro  Leu Ser Pro Gln Thr  Gly Pro Pro Ala His  Ser Ala Ser 
    1160                 1165                 1170             


Leu Ile  Pro Ser Val Ser Asn  Gly Ser Leu Lys Phe  Gln Ser Leu 
    1175                 1180                 1185             


Thr His  Thr Gly Lys Gly His  His Leu Ser Phe Ser  Pro Gln Ser 
    1190                 1195                 1200             


Gln Asn  Gly Arg Ala Pro Pro  Pro Leu Ser Phe Ser  Ser Ser Pro 
    1205                 1210                 1215             


Pro Ser  Pro Ala Ser Ser Val  Ser Leu Asn Gln Gly  Ala Lys Gly 
    1220                 1225                 1230             


Thr Arg  Thr Ile His Thr Pro  Ser Leu Thr Ser Tyr  Lys Ala Gln 
    1235                 1240                 1245             


Asn Gly  Ser Ser Ser Lys Ala  Thr Pro Ser Thr Ala  Lys Glu Thr 
    1250                 1255                 1260             


Ser 
    


<210>  5851
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1279__Homo_sapiens__NP_056449

<400>  5851

Met Ala Asn Val Pro Trp Ala Glu Val Cys Glu Lys Phe Gln Ala Ala 
1               5                   10                  15      


Leu Ala Leu Ser Arg Val Glu Leu His Lys Asn Pro Glu Lys Glu Pro 
            20                  25                  30          


Tyr Lys Ser Lys Tyr Ser Ala Arg Ala Leu Leu Glu Glu Val Lys Ala 
        35                  40                  45              


Leu Leu Gly Pro Ala Pro Glu Asp Glu Asp Glu Arg Pro Glu Ala Glu 
    50                  55                  60                  


Asp Gly Pro Gly Ala Gly Asp His Ala Leu Gly Leu Pro Ala Glu Val 
65                  70                  75                  80  


Val Glu Pro Glu Gly Pro Val Ala Gln Arg Ala Val Arg Leu Ala Val 
                85                  90                  95      


Ile Glu Phe His Leu Gly Val Asn His Ile Asp Thr Glu Glu Leu Ser 
            100                 105                 110         


Ala Gly Glu Glu His Leu Val Lys Cys Leu Arg Leu Leu Arg Arg Tyr 
        115                 120                 125             


Arg Leu Ser His Asp Cys Ile Ser Leu Cys Ile Gln Ala Gln Asn Asn 
    130                 135                 140                 


Leu Gly Ile Leu Trp Ser Glu Arg Glu Glu Ile Glu Thr Ala Gln Ala 
145                 150                 155                 160 


Tyr Leu Glu Ser Ser Glu Ala Leu Tyr Asn Gln Tyr Met Lys Glu Val 
                165                 170                 175     


Gly Ser Pro Pro Leu Asp Pro Thr Glu Arg Phe Leu Pro Glu Glu Glu 
            180                 185                 190         


Lys Leu Thr Glu Gln Glu Arg Ser Lys Arg Phe Glu Lys Val Tyr Thr 
        195                 200                 205             


His Asn Leu Tyr Tyr Leu Ala Gln Val Tyr Gln His Leu Glu Met Phe 
    210                 215                 220                 


Glu Lys Ala Ala His Tyr Cys His Ser Thr Leu Lys Arg Gln Leu Glu 
225                 230                 235                 240 


His Asn Ala Tyr His Pro Ile Glu Trp Ala Ile Asn Ala Ala Thr Leu 
                245                 250                 255     


Ser Gln Phe Tyr Ile Asn Lys Leu Cys Phe Met Glu Ala Arg His Cys 
            260                 265                 270         


Leu Ser Ala Ala Asn Val Ile Phe Gly Gln Thr Gly Lys Ile Ser Ala 
        275                 280                 285             


Thr Glu Asp Thr Pro Glu Ala Glu Gly Glu Val Pro Glu Leu Tyr His 
    290                 295                 300                 


Gln Arg Lys Gly Glu Ile Ala Arg Cys Trp Ile Lys Tyr Cys Leu Thr 
305                 310                 315                 320 


Leu Met Gln Asn Ala Gln Leu Ser Met Gln Asp Asn Ile Gly Glu Leu 
                325                 330                 335     


Asp Leu Asp Lys Gln Ser Glu Leu Arg Ala Leu Arg Lys Lys Glu Leu 
            340                 345                 350         


Asp Glu Glu Glu Ser Ile Arg Lys Lys Ala Val Gln Phe Gly Thr Gly 
        355                 360                 365             


Glu Leu Cys Asp Ala Ile Ser Ala Val Glu Glu Lys Val Ser Tyr Leu 
    370                 375                 380                 


Arg Pro Leu Asp Phe Glu Glu Ala Arg Glu Leu Phe Leu Leu Gly Gln 
385                 390                 395                 400 


His Tyr Val Phe Glu Ala Lys Glu Phe Phe Gln Ile Asp Gly Tyr Val 
                405                 410                 415     


Thr Asp His Ile Glu Val Val Gln Asp His Ser Ala Leu Phe Lys Val 
            420                 425                 430         


Leu Ala Phe Phe Glu Thr Asp Met Glu Arg Arg Cys Lys Met His Lys 
        435                 440                 445             


Arg Arg Ile Ala Met Leu Glu Pro Leu Thr Val Asp Leu Asn Pro Gln 
    450                 455                 460                 


Tyr Tyr Leu Leu Val Asn Arg Gln Ile Gln Phe Glu Ile Ala His Ala 
465                 470                 475                 480 


Tyr Tyr Asp Met Met Asp Leu Lys Val Ala Ile Ala Asp Arg Leu Arg 
                485                 490                 495     


Asp Pro Asp Ser His Ile Val Lys Lys Ile Asn Asn Leu Asn Lys Ser 
            500                 505                 510         


Ala Leu Lys Tyr Tyr Gln Leu Phe Leu Asp Ser Leu Arg Asp Pro Asn 
        515                 520                 525             


Lys Val Phe Pro Glu His Ile Gly Glu Asp Val Leu Arg Pro Ala Met 
    530                 535                 540                 


Leu Ala Lys Phe Arg Val Ala Arg Leu Tyr Gly Lys Ile Ile Thr Ala 
545                 550                 555                 560 


Asp Pro Lys Lys Glu Leu Glu Asn Leu Ala Thr Ser Leu Glu His Tyr 
                565                 570                 575     


Lys Phe Ile Val Asp Tyr Cys Glu Lys His Pro Glu Ala Ala Gln Glu 
            580                 585                 590         


Ile Glu Val Glu Leu Glu Leu Ser Lys Glu Met Val Ser Leu Leu Pro 
        595                 600                 605             


Thr Lys Met Glu Arg Phe Arg Thr Lys Met Ala Leu Thr 
    610                 615                 620     


<210>  5852
<211>  1004
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1324__Homo_sapiens__XP_011540127

<400>  5852

Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly 
1               5                   10                  15      


Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala 
            20                  25                  30          


Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala 
        35                  40                  45              


Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr 
    50                  55                  60                  


Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr 
65                  70                  75                  80  


Ser Leu Pro Asp Pro Ile Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn 
                85                  90                  95      


Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala 
            100                 105                 110         


Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp 
        115                 120                 125             


Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp 
    130                 135                 140                 


Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val 
145                 150                 155                 160 


Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr 
                165                 170                 175     


Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu 
            180                 185                 190         


Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn 
        195                 200                 205             


Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr 
    210                 215                 220                 


Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn 
225                 230                 235                 240 


Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro 
                245                 250                 255     


Lys Pro Val Leu Val Arg Asn Ile Ala Ile Thr Gly Val Ala Tyr Thr 
            260                 265                 270         


Ser Glu Cys Phe Pro Cys Lys Pro Gly Thr Tyr Ala Asp Lys Gln Gly 
        275                 280                 285             


Ser Ser Phe Cys Lys Leu Cys Pro Ala Asn Ser Tyr Ser Asn Lys Gly 
    290                 295                 300                 


Glu Thr Ser Cys His Gln Cys Asp Pro Asp Lys Tyr Ser Glu Lys Gly 
305                 310                 315                 320 


Ser Ser Ser Cys Asn Val Arg Pro Ala Cys Thr Asp Lys Asp Tyr Phe 
                325                 330                 335     


Tyr Thr His Thr Ala Cys Asp Ala Asn Gly Glu Thr Gln Leu Met Tyr 
            340                 345                 350         


Lys Trp Ala Lys Pro Lys Ile Cys Ser Glu Asp Leu Glu Gly Ala Val 
        355                 360                 365             


Lys Leu Pro Ala Ser Gly Val Lys Thr His Cys Pro Pro Cys Asn Pro 
    370                 375                 380                 


Gly Phe Phe Lys Thr Asn Asn Ser Thr Cys Gln Pro Cys Pro Tyr Gly 
385                 390                 395                 400 


Ser Tyr Ser Asn Gly Ser Asp Cys Thr Arg Cys Pro Ala Gly Thr Glu 
                405                 410                 415     


Pro Ala Val Gly Phe Glu Tyr Lys Trp Trp Asn Thr Leu Pro Thr Asn 
            420                 425                 430         


Met Glu Thr Thr Val Leu Ser Gly Ile Asn Phe Glu Tyr Lys Gly Met 
        435                 440                 445             


Thr Gly Trp Glu Val Ala Gly Asp His Ile Tyr Thr Ala Ala Gly Ala 
    450                 455                 460                 


Ser Asp Asn Asp Phe Met Ile Leu Thr Leu Val Val Pro Gly Phe Arg 
465                 470                 475                 480 


Pro Pro Gln Ser Val Met Ala Asp Thr Glu Asn Lys Glu Val Ala Arg 
                485                 490                 495     


Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Val Asn Cys Glu Leu Tyr 
            500                 505                 510         


Phe Met Val Gly Val Asn Ser Arg Thr Asn Thr Pro Val Glu Thr Trp 
        515                 520                 525             


Lys Gly Ser Lys Gly Lys Gln Ser Tyr Thr Tyr Ile Ile Glu Glu Asn 
    530                 535                 540                 


Thr Thr Thr Ser Phe Thr Trp Ala Phe Gln Arg Thr Thr Phe His Glu 
545                 550                 555                 560 


Ala Ser Arg Lys Tyr Thr Asn Asp Val Ala Lys Ile Tyr Ser Ile Asn 
                565                 570                 575     


Val Thr Asn Val Met Asn Gly Val Ala Ser Tyr Cys Arg Pro Cys Ala 
            580                 585                 590         


Leu Glu Ala Ser Asp Val Gly Ser Ser Cys Thr Ser Cys Pro Ala Gly 
        595                 600                 605             


Tyr Tyr Ile Asp Arg Asp Ser Gly Thr Cys His Ser Cys Pro Thr Asn 
    610                 615                 620                 


Thr Ile Leu Lys Ala His Gln Pro Tyr Gly Val Gln Ala Cys Val Pro 
625                 630                 635                 640 


Cys Gly Pro Gly Thr Lys Asn Asn Lys Ile His Ser Leu Cys Tyr Asn 
                645                 650                 655     


Asp Cys Thr Phe Ser Arg Asn Thr Pro Thr Arg Thr Phe Asn Tyr Asn 
            660                 665                 670         


Phe Ser Ala Leu Ala Asn Thr Val Thr Leu Ala Gly Gly Pro Ser Phe 
        675                 680                 685             


Thr Ser Lys Gly Leu Lys Tyr Phe His His Phe Thr Leu Ser Leu Cys 
    690                 695                 700                 


Gly Asn Gln Gly Arg Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp 
705                 710                 715                 720 


Leu Arg Ile Pro Glu Gly Glu Ser Gly Phe Ser Lys Ser Ile Thr Ala 
                725                 730                 735     


Tyr Val Cys Gln Ala Val Ile Ile Pro Pro Glu Val Thr Gly Tyr Lys 
            740                 745                 750         


Ala Gly Val Ser Ser Gln Pro Val Ser Leu Ala Asp Arg Leu Ile Gly 
        755                 760                 765             


Val Thr Thr Asp Met Thr Leu Asp Gly Ile Thr Ser Pro Ala Glu Leu 
    770                 775                 780                 


Phe His Leu Glu Ser Leu Gly Ile Pro Asp Val Ile Phe Phe Tyr Arg 
785                 790                 795                 800 


Ser Asn Asp Val Thr Gln Ser Cys Ser Ser Gly Arg Ser Thr Thr Ile 
                805                 810                 815     


Arg Val Arg Cys Ser Pro Gln Lys Thr Val Pro Gly Ser Leu Leu Leu 
            820                 825                 830         


Pro Gly Thr Cys Ser Asp Gly Thr Cys Asp Gly Cys Asn Phe His Phe 
        835                 840                 845             


Leu Trp Glu Ser Ala Ala Ala Cys Pro Leu Cys Ser Val Ala Asp Tyr 
    850                 855                 860                 


His Ala Ile Val Ser Ser Cys Val Ala Gly Ile Gln Lys Thr Thr Tyr 
865                 870                 875                 880 


Val Trp Arg Glu Pro Lys Leu Cys Ser Gly Gly Ile Ser Leu Pro Glu 
                885                 890                 895     


Gln Arg Val Thr Ile Cys Lys Thr Ile Asp Phe Trp Leu Lys Val Gly 
            900                 905                 910         


Ile Ser Ala Gly Thr Cys Thr Ala Ile Leu Leu Thr Val Leu Thr Cys 
        915                 920                 925             


Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu 
    930                 935                 940                 


Val Met Asn Ala Thr Leu Lys Asp Cys Asp Leu Pro Ala Ala Asp Ser 
945                 950                 955                 960 


Cys Ala Ile Met Glu Gly Glu Asp Val Glu Asp Asp Leu Ile Phe Thr 
                965                 970                 975     


Ser Lys Lys Ser Leu Phe Gly Lys Ile Lys Ser Phe Thr Ser Lys Gln 
            980                 985                 990         


Pro Ala Pro Val Thr Ile Ser Leu  Ser Glu Asp Ser 
        995                 1000                 


<210>  5853
<211>  1029
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1324L__Homo_sapiens__NP_001136221

<400>  5853

Met Leu Phe Arg Ala Arg Gly Pro Val Arg Gly Arg Gly Trp Gly Arg 
1               5                   10                  15      


Pro Ala Glu Ala Pro Arg Arg Gly Arg Ser Pro Pro Trp Ser Pro Ala 
            20                  25                  30          


Trp Ile Cys Cys Trp Ala Leu Ala Gly Cys Gln Ala Ala Trp Ala Gly 
        35                  40                  45              


Asp Leu Pro Ser Ser Ser Ser Arg Pro Leu Pro Pro Cys Gln Glu Lys 
    50                  55                  60                  


Asp Tyr His Phe Glu Tyr Thr Glu Cys Asp Ser Ser Gly Ser Arg Trp 
65                  70                  75                  80  


Arg Val Ala Ile Pro Asn Ser Ala Val Asp Cys Ser Gly Leu Pro Asp 
                85                  90                  95      


Pro Val Arg Gly Lys Glu Cys Thr Phe Ser Cys Ala Ser Gly Glu Tyr 
            100                 105                 110         


Leu Glu Met Lys Asn Gln Val Cys Ser Lys Cys Gly Glu Gly Thr Tyr 
        115                 120                 125             


Ser Leu Gly Ser Gly Ile Lys Phe Asp Glu Trp Asp Glu Leu Pro Ala 
    130                 135                 140                 


Gly Phe Ser Asn Ile Ala Thr Phe Met Asp Thr Val Val Gly Pro Ser 
145                 150                 155                 160 


Asp Ser Arg Pro Asp Gly Cys Asn Asn Ser Ser Trp Ile Pro Arg Gly 
                165                 170                 175     


Asn Tyr Ile Glu Ser Asn Arg Asp Asp Cys Thr Val Ser Leu Ile Tyr 
            180                 185                 190         


Ala Val His Leu Lys Lys Ser Gly Tyr Val Phe Phe Glu Tyr Gln Tyr 
        195                 200                 205             


Val Asp Asn Asn Ile Phe Phe Glu Phe Phe Ile Gln Asn Asp Gln Cys 
    210                 215                 220                 


Gln Glu Met Asp Thr Thr Thr Asp Lys Trp Val Lys Leu Thr Asp Asn 
225                 230                 235                 240 


Gly Glu Trp Gly Ser His Ser Val Met Leu Lys Ser Gly Thr Asn Ile 
                245                 250                 255     


Leu Tyr Trp Arg Thr Thr Gly Ile Leu Met Gly Ser Lys Ala Val Lys 
            260                 265                 270         


Pro Val Leu Val Lys Asn Ile Thr Ile Glu Gly Val Ala Tyr Thr Ser 
        275                 280                 285             


Glu Cys Phe Pro Cys Lys Pro Gly Thr Phe Ser Asn Lys Pro Gly Ser 
    290                 295                 300                 


Phe Asn Cys Gln Val Cys Pro Arg Asn Thr Tyr Ser Glu Lys Gly Ala 
305                 310                 315                 320 


Lys Glu Cys Ile Arg Cys Lys Asp Asp Ser Gln Phe Ser Glu Glu Gly 
                325                 330                 335     


Ser Ser Glu Cys Thr Glu Arg Pro Pro Cys Thr Thr Lys Asp Tyr Phe 
            340                 345                 350         


Gln Ile His Thr Pro Cys Asp Glu Glu Gly Lys Thr Gln Ile Met Tyr 
        355                 360                 365             


Lys Trp Ile Glu Pro Lys Ile Cys Arg Glu Asp Leu Thr Asp Ala Ile 
    370                 375                 380                 


Arg Leu Pro Pro Ser Gly Glu Lys Lys Asp Cys Pro Pro Cys Asn Pro 
385                 390                 395                 400 


Gly Phe Tyr Asn Asn Gly Ser Ser Ser Cys His Pro Cys Pro Pro Gly 
                405                 410                 415     


Thr Phe Ser Asp Gly Thr Lys Glu Cys Arg Pro Cys Pro Ala Gly Thr 
            420                 425                 430         


Glu Pro Ala Leu Gly Phe Glu Tyr Lys Trp Trp Asn Val Leu Pro Gly 
        435                 440                 445             


Asn Met Lys Thr Ser Cys Phe Asn Val Gly Asn Ser Lys Cys Asp Gly 
    450                 455                 460                 


Met Asn Gly Trp Glu Val Ala Gly Asp His Ile Gln Ser Gly Ala Gly 
465                 470                 475                 480 


Gly Ser Asp Asn Asp Tyr Leu Ile Leu Asn Leu His Ile Pro Gly Phe 
                485                 490                 495     


Lys Pro Pro Thr Ser Met Thr Gly Ala Thr Gly Ser Glu Leu Gly Arg 
            500                 505                 510         


Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Ala Asp Cys Val Leu Tyr 
        515                 520                 525             


Phe Met Val Asp Ile Asn Arg Lys Ser Thr Asn Val Val Glu Ser Trp 
    530                 535                 540                 


Gly Gly Thr Lys Glu Lys Gln Ala Tyr Thr His Ile Ile Phe Lys Asn 
545                 550                 555                 560 


Ala Thr Phe Thr Phe Thr Trp Ala Phe Gln Arg Thr Asn Gln Gly Gln 
                565                 570                 575     


Asp Asn Arg Arg Phe Ile Asn Asp Met Val Lys Ile Tyr Ser Ile Thr 
            580                 585                 590         


Ala Thr Asn Ala Val Asp Gly Val Ala Ser Ser Cys Arg Ala Cys Ala 
        595                 600                 605             


Leu Gly Ser Glu Gln Ser Gly Ser Ser Cys Val Pro Cys Pro Pro Gly 
    610                 615                 620                 


His Tyr Ile Glu Lys Glu Thr Asn Gln Cys Lys Glu Cys Pro Pro Asp 
625                 630                 635                 640 


Thr Tyr Leu Ser Ile His Gln Val Tyr Gly Lys Glu Ala Cys Ile Pro 
                645                 650                 655     


Cys Gly Pro Gly Ser Lys Asn Asn Gln Asp His Ser Val Cys Tyr Ser 
            660                 665                 670         


Asp Cys Phe Phe Tyr His Glu Lys Glu Asn Gln Ser Leu His Tyr Asp 
        675                 680                 685             


Phe Ser Asn Leu Ser Ser Val Gly Ser Leu Met Asn Gly Pro Ser Phe 
    690                 695                 700                 


Thr Ser Lys Gly Thr Lys Tyr Phe His Phe Phe Asn Ile Ser Leu Cys 
705                 710                 715                 720 


Gly His Glu Gly Lys Lys Met Ala Leu Cys Thr Asn Asn Ile Thr Asp 
                725                 730                 735     


Phe Thr Val Lys Glu Ile Val Ala Gly Ser Asp Asp Tyr Thr Asn Leu 
            740                 745                 750         


Val Gly Ala Phe Val Cys Gln Ser Thr Ile Ile Pro Ser Glu Ser Lys 
        755                 760                 765             


Gly Phe Arg Ala Ala Leu Ser Ser Gln Ser Ile Ile Leu Ala Asp Thr 
    770                 775                 780                 


Phe Ile Gly Val Thr Val Glu Thr Thr Leu Lys Asn Ile Asn Ile Lys 
785                 790                 795                 800 


Glu Asp Met Phe Pro Val Pro Thr Ser Gln Ile Pro Asp Val His Phe 
                805                 810                 815     


Phe Tyr Lys Ser Ser Thr Ala Thr Thr Ser Cys Ile Asn Gly Arg Ser 
            820                 825                 830         


Thr Ala Val Lys Met Arg Cys Asn Pro Thr Lys Ser Gly Ala Gly Val 
        835                 840                 845             


Ile Ser Val Pro Ser Lys Cys Pro Ala Gly Thr Cys Asp Gly Cys Thr 
    850                 855                 860                 


Phe Tyr Phe Leu Trp Glu Ser Ala Glu Ala Cys Pro Leu Cys Thr Glu 
865                 870                 875                 880 


His Asp Phe His Glu Ile Glu Gly Ala Cys Lys Arg Gly Phe Gln Glu 
                885                 890                 895     


Thr Leu Tyr Val Trp Asn Glu Pro Lys Trp Cys Ile Lys Gly Ile Ser 
            900                 905                 910         


Leu Pro Glu Lys Lys Leu Ala Thr Cys Glu Thr Val Asp Phe Trp Leu 
        915                 920                 925             


Lys Val Gly Ala Gly Val Gly Ala Phe Thr Ala Val Leu Leu Val Ala 
    930                 935                 940                 


Leu Thr Cys Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr 
945                 950                 955                 960 


Ser Lys Leu Val Met Thr Thr Asn Ser Lys Glu Cys Glu Leu Pro Ala 
                965                 970                 975     


Ala Asp Ser Cys Ala Ile Met Glu Gly Glu Asp Asn Glu Glu Glu Val 
            980                 985                 990         


Val Tyr Ser Asn Lys Gln Ser Leu  Leu Gly Lys Leu Lys  Ser Leu Ala 
        995                 1000                 1005             


Thr Lys  Glu Lys Glu Asp His  Phe Glu Ser Val Gln  Leu Lys Thr 
    1010                 1015                 1020             


Ser Arg  Ser Pro Asn Ile 
    1025                 


<210>  5854
<211>  1117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1377__Homo_sapiens__NP_065853

<400>  5854

Met Leu Ala Gly Arg Pro Gly Thr Arg Ser Ala Val Gly Glu Leu Gly 
1               5                   10                  15      


Thr Glu Ser Ser Asp Asn Leu Asp Arg Ala Pro Leu Gly Pro Arg Glu 
            20                  25                  30          


Ser Gly Gly His His Arg Pro Gly Ser Tyr Leu Asp Met Lys Ile His 
        35                  40                  45              


Leu Glu Lys Asn Leu Glu Glu Glu Arg Gln Ile Leu Leu Gln Gln Gln 
    50                  55                  60                  


Lys Ile Cys Arg Asn Arg Ala Arg Lys Tyr Phe Val Glu Ser Asn Arg 
65                  70                  75                  80  


Arg Lys Lys Ala Phe Glu Glu Lys Arg Lys Glu Gln Glu Glu Lys Glu 
                85                  90                  95      


His Gln Ile Arg Glu Gln Ile Leu Gln Gln Arg Lys Gln Lys Phe Glu 
            100                 105                 110         


Glu Val Thr Glu Lys Phe Gln Arg Ala His Val Pro Leu Ser Gln Arg 
        115                 120                 125             


Arg Lys Ala Val Ser Arg Lys Pro Val Pro Pro Leu Glu Glu Ala Leu 
    130                 135                 140                 


Lys Gln Ile Gln Glu Ser Asn Leu Lys Ser Glu Val Asn Leu Pro Phe 
145                 150                 155                 160 


Ser Arg Arg Pro Thr Ile Asn Trp Arg Ala Ile Asp Ser Ala Leu Pro 
                165                 170                 175     


Ser Ala Leu Ser Lys Asn Asp His Lys His Gln Lys Gln Leu Leu Ser 
            180                 185                 190         


Lys Ile Asn Cys Glu Lys Glu Met Asn Glu Asn Met Arg Ala Thr Leu 
        195                 200                 205             


Ala Thr Ser Lys Asn Val Phe Gln Leu Lys Leu Glu Glu Thr Gln Lys 
    210                 215                 220                 


Leu Leu Glu Asp Gln His Leu Ser Asn Leu Gln Lys Phe Cys Asp Glu 
225                 230                 235                 240 


Val Asn Gln Ile Thr Asn Ser Glu Thr Leu Ser Ser Ile Asp Ser Leu 
                245                 250                 255     


Glu Ala Thr Glu His Glu Glu Ile Tyr Leu Thr Leu Asn Lys Glu His 
            260                 265                 270         


Ser Thr Ser Ile Gln Arg Asn Thr Ile Ser Leu Lys Pro Ala Asn Met 
        275                 280                 285             


Gln Ser Thr Asn Leu Ser Cys Phe Asp Glu Asp Lys Leu Ala Phe Ser 
    290                 295                 300                 


Lys Thr Gln His Ile Asn Asn Trp Leu Thr Asn Leu Asp Ala Ser Asn 
305                 310                 315                 320 


Thr Gln Asn Val Thr Ala Phe Ser Asp Ile Leu Ser Lys Ser Asn Val 
                325                 330                 335     


Leu Pro Ser Trp Glu Tyr Phe Asn Ser Lys Glu Gln Asn Pro Ser Pro 
            340                 345                 350         


Leu Asn Gly Thr Val Glu Arg Ala Thr Asn Thr Ala Asn Asn Ser Val 
        355                 360                 365             


Pro Phe Val Ser Ser Pro Pro Met Phe Val Leu Asp Lys Lys Cys Glu 
    370                 375                 380                 


Lys Thr Ser Glu Thr Ser Thr Met Arg Thr Thr Asp Ser Thr Ser Gly 
385                 390                 395                 400 


Ala Phe Lys Arg Glu Arg Pro Leu Val Thr Glu Ser Pro Thr Phe Lys 
                405                 410                 415     


Phe Ser Lys Ser Gln Ser Thr Ser Asp Ser Leu Thr Gln Glu Val Ala 
            420                 425                 430         


Thr Phe Pro Asp Gln Glu Lys Tyr Ser Glu Leu Asn Gln Glu Asn Gly 
        435                 440                 445             


Thr Thr Ser Ile Pro Thr Ser Cys Val Pro Val Ala Thr Pro Leu Val 
    450                 455                 460                 


Leu Pro Ser Asn Ile Gln Ser Ala Arg Pro Ser Ala Lys Asn Ser Ile 
465                 470                 475                 480 


His Ile Lys Glu Ile Asp Ala Val Gln Cys Ser Asp Lys Leu Asp Glu 
                485                 490                 495     


Leu Lys Asp Gly Lys Glu Glu Glu Ile Lys Tyr Phe Asn Cys Asn Lys 
            500                 505                 510         


Glu Glu Leu Pro Leu Phe Ser Asp Ser Phe Gln Asp Ala Tyr Ile Pro 
        515                 520                 525             


His Asn Pro Asp Ser Lys Asp Glu Lys Gln Lys Leu Ala Glu Thr Ser 
    530                 535                 540                 


Ser Leu Ser Asn Val Thr Ser Asn Tyr Asp Phe Val Gly Gln His Lys 
545                 550                 555                 560 


Lys Met Lys Tyr Asn Ile His Glu Arg Asn Gly Val Arg Phe Leu Lys 
                565                 570                 575     


Ser Ile Leu Lys Lys Glu Ser Lys Tyr Glu His Gly Tyr Leu Lys Ala 
            580                 585                 590         


Leu Ile Ile Asn Gln Ser Phe Lys Phe Gly Asn Gln Lys Ala Ala Ala 
        595                 600                 605             


Ile Arg Asp Ser Ile Glu Leu Thr Lys Glu Lys Gly Ala Glu Ile Pro 
    610                 615                 620                 


Lys Thr Ile Lys Lys Leu Arg Trp Phe Asp Glu Thr Ser Asn Ile Glu 
625                 630                 635                 640 


Asn Asn Ala Glu Asn Ser His Ser Leu Lys Asn Lys Thr Gly Thr Thr 
                645                 650                 655     


Gln Gln His Ser Gln Gln Phe His Ile Gln Ser Gly Ala Gly Ser Asn 
            660                 665                 670         


Ile Ile Ser Val Ser Thr Cys Ala Val Asn Ser Ala Asp Thr Lys Lys 
        675                 680                 685             


Ser Arg Glu Asp Ser Ile Ser Glu Asn Val Thr Thr Leu Gly Gly Ser 
    690                 695                 700                 


Gly Ala Asp His Met Pro Leu Asn Cys Phe Ile Pro Ser Gly Tyr Asn 
705                 710                 715                 720 


Phe Ala Lys His Ala Trp Pro Ala Ser Lys Lys Glu Glu Ser Lys Ile 
                725                 730                 735     


Pro Val His Asp Asp Ser Lys Thr Lys Gln Gly Lys Pro Gln Arg Gly 
            740                 745                 750         


Arg Ala Lys Ile Ile Arg Lys Pro Gly Ser Ala Lys Val Gln Ser Gly 
        755                 760                 765             


Phe Ile Cys Thr Asn Arg Lys Gly Ala Val Ile Gln Pro Gln Ser Ala 
    770                 775                 780                 


Ser Lys Val Asn Ile Phe Thr Gln Ala Gln Gly Lys Leu Ile Ile Pro 
785                 790                 795                 800 


Cys Pro Pro Pro Gln Ser Thr Ser Asn Ile Arg Ser Gly Lys Asn Ile 
                805                 810                 815     


Gln Val Ser Gln Cys Gln Pro Val Thr Pro Glu Asn Pro Gln Asn Ile 
            820                 825                 830         


Ile Thr His Asn Ser Phe Asn Ser Lys His Val Leu Pro Thr Glu His 
        835                 840                 845             


Ser Leu Asn Gln Trp Asn Gln Glu Ser Ser Ser Pro Leu Ser Asn Ala 
    850                 855                 860                 


Cys Ser Asp Leu Val Thr Val Ile Pro Ser Leu Pro Ser Tyr Cys Ser 
865                 870                 875                 880 


Ser Glu Cys Gln Thr Phe Ala Lys Ile Asn His Ser Asn Gly Thr Gln 
                885                 890                 895     


Ala Val Ala Arg Gln Asp Ala Thr Leu Tyr Cys Thr Gln Arg Ser Pro 
            900                 905                 910         


Val Cys Glu Glu Ser Tyr Pro Ser Val Thr Leu Arg Thr Ala Glu Glu 
        915                 920                 925             


Glu Ser Val Pro Leu Trp Lys Arg Gly Pro Asn Val Leu His Gln Asn 
    930                 935                 940                 


Lys Arg Ala Thr Gly Ser Thr Val Met Arg Arg Lys Arg Ile Ala Glu 
945                 950                 955                 960 


Thr Lys Arg Arg Asn Ile Leu Glu Gln Lys Arg Gln Asn Pro Gly Ser 
                965                 970                 975     


Val Gly Gln Lys Tyr Ser Glu Gln Ile Asn Asn Phe Gly Gln Ser Val 
            980                 985                 990         


Leu Leu Ser Ser Ser Glu Pro Lys  Gln Thr Thr Arg Gly  Thr Ser Tyr 
        995                 1000                 1005             


Ile Glu  Glu Val Ser Asp Ser  Thr Ser Glu Phe Leu  Met Ala Glu 
    1010                 1015                 1020             


Asn Leu  Val Lys Ala Ser Val  Pro Glu Asp Glu Ile  Leu Thr Val 
    1025                 1030                 1035             


Leu Asn  Ser Lys Gln Ile Gln  Lys Ser Asn Leu Pro  Leu Asn Lys 
    1040                 1045                 1050             


Thr Gln  Gln Phe Asn Ile Cys  Thr Leu Ser Ala Glu  Glu Gln Lys 
    1055                 1060                 1065             


Ile Leu  Glu Ser Leu Asn Asp  Leu Ser Glu Arg Leu  His Tyr Ile 
    1070                 1075                 1080             


Gln Glu  Ser Ile Cys Lys Asn  Pro Ser Ile Lys Asn  Thr Leu Gln 
    1085                 1090                 1095             


Ile Ile  Pro Leu Leu Glu Lys  Arg Glu Asp Arg Thr  Ser Ser Cys 
    1100                 1105                 1110             


Arg Asp  Lys Arg 
    1115         


<210>  5855
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1456__Homo_sapiens__XP_005273641

<400>  5855

Met Lys Ile Gln Phe Lys Lys Glu Cys Gln Asn Arg Lys Gly Leu Cys 
1               5                   10                  15      


Phe Leu Gln Arg Leu Thr Gln Glu Val Tyr His Glu Lys Asp Arg Thr 
            20                  25                  30          


Ile Ser Phe His Ser Tyr Lys Phe Ser Phe Thr Leu His Ile Glu Lys 
        35                  40                  45              


Val Met Arg Ser Asn Cys His Ser Leu Glu Val Glu Thr Ala Val Ile 
    50                  55                  60                  


His Lys Asp Lys Arg Met Asp His Glu Ala Ala Gln Leu Glu Lys Gln 
65                  70                  75                  80  


His Val His Asn Val Tyr Glu Ser Thr Ala Pro Tyr Phe Ser Asp Leu 
                85                  90                  95      


Gln Ser Lys Ala Trp Pro Arg Val Arg Gln Phe Leu Gln Glu Gln Lys 
            100                 105                 110         


Pro Gly Ser Leu Ile Ala Asp Ile Gly Cys Gly Thr Gly Lys Tyr Leu 
        115                 120                 125             


Lys Val Asn Ser Gln Val His Thr Val Gly Cys Asp Tyr Cys Gly Pro 
    130                 135                 140                 


Leu Val Glu Ile Ala Arg Asn Arg Gly Cys Glu Ala Met Val Cys Asp 
145                 150                 155                 160 


Asn Leu Asn Leu Pro Phe Arg Asp Glu Gly Phe Asp Ala Ile Ile Ser 
                165                 170                 175     


Ile Gly Val Ile His His Phe Ser Thr Lys Gln Arg Arg Ile Arg Ala 
            180                 185                 190         


Ile Lys Glu Met Ala Arg Val Leu Val Pro Gly Gly Gln Leu Met Ile 
        195                 200                 205             


Tyr Val Trp Ala Met Glu Gln Lys Asn Arg His Phe Glu Lys Gln Asp 
    210                 215                 220                 


Val Leu Val Pro Trp Asn Arg Ala Leu Cys Ser Gln Leu Phe Ser Glu 
225                 230                 235                 240 


Ser Ser Gln Ser Gly Arg Lys Arg Gln Cys Gly Tyr Pro Glu Arg Gly 
                245                 250                 255     


His Pro Tyr His Pro Pro Cys Ser Glu Cys Ser Cys Ser Val Cys Phe 
            260                 265                 270         


Lys Glu Gln Cys Gly Ser Lys Arg Ser His Ser Val Gly Tyr Glu Pro 
        275                 280                 285             


Ala Met Ala Arg Thr Cys Phe Ala Asn Ile Ser Lys Glu Gly Glu Glu 
    290                 295                 300                 


Glu Tyr Gly Phe Tyr Ser Thr Leu Gly Lys Ser Phe Arg Ser Trp Phe 
305                 310                 315                 320 


Phe Ser Arg Ser Leu Asp Glu Ser Thr Leu Arg Lys Gln Ile Glu Arg 
                325                 330                 335     


Val Arg Pro Leu Lys Asn Thr Glu Val Trp Ala Ser Ser Thr Val Thr 
            340                 345                 350         


Val Gln Pro Ser Arg His Ser Ser Leu Asp Phe Asp His Gln Glu Pro 
        355                 360                 365             


Phe Ser Thr Lys Gly Gln Ser Leu Asp Glu Glu Val Phe Val Glu Ser 
    370                 375                 380                 


Ser Ser Gly Lys His Leu Glu Trp Leu Arg Ala Pro Gly Thr Leu Lys 
385                 390                 395                 400 


His Leu Asn Gly Asp His Gln Gly Glu Met Arg Arg Asn Gly Gly Gly 
                405                 410                 415     


Asn Phe Leu Asp Ser Thr Asn Thr Gly Val Asn Cys Val Asp Ala Gly 
            420                 425                 430         


Asn Ile Glu Asp Asp Asn Pro Ser Ala Ser Lys Ile Leu Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Asp Ser Thr Asp Phe Asn Pro Asp Asp Thr Met Ser Val 
    450                 455                 460                 


Glu Asp Pro Gln Thr Asp Val Leu Asp Ser Thr Ala Phe Met Arg Tyr 
465                 470                 475                 480 


Tyr His Val Phe Arg Glu Gly Glu Leu Cys Ser Leu Leu Lys Glu Asn 
                485                 490                 495     


Val Ser Glu Leu Arg Ile Leu Ser Ser Gly Asn Asp His Gly Asn Trp 
            500                 505                 510         


Cys Ile Ile Ala Glu Lys Lys Arg Gly Cys Asp 
        515                 520             


<210>  5856
<211>  1359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1462__Homo_sapiens__XP_011517910

<400>  5856

Met Tyr Ser Val Glu Asp Leu Leu Ile Ser His Gly Tyr Lys Leu Ser 
1               5                   10                  15      


Arg Asp Pro Pro Ala Ser Arg Glu Asp Asn Pro Lys Gly Arg Gln Ala 
            20                  25                  30          


Ala Arg Thr Gly Thr Arg Ala Gly Gln Gly Leu Gln Asn Gly His Glu 
        35                  40                  45              


Asp Gly Pro Ala Ala Leu Ala His Arg Lys Thr Ser Ala Gly Lys Gly 
    50                  55                  60                  


His Val Ser Asp Ser Glu Ser Arg Arg Ser Thr Pro Arg Gly His Gly 
65                  70                  75                  80  


Glu Pro Gln Ser Thr Ser Ala Ser Arg Thr Ser Glu Ala Gly Phe Cys 
                85                  90                  95      


Asn Gln Pro Pro Ser Ala Trp Ser Ser His Pro Pro Thr Gly Asn Asp 
            100                 105                 110         


Gln Ala Tyr Arg Arg Arg Gly Arg Gln Glu Ala Arg Ser Gln Lys Pro 
        115                 120                 125             


Arg Glu His Glu Asn Leu Glu Ala Arg Gly Met Ala Gln Ala His Ser 
    130                 135                 140                 


Leu Pro Val His Val Arg Glu Gly Pro Trp Glu Val Gly Gly Arg Ser 
145                 150                 155                 160 


Glu His Val Met Lys Lys Pro Val Trp Glu Glu Glu Leu Arg Met Ser 
                165                 170                 175     


Gly Pro Ala Lys Trp Gln Asn Val Ser Leu Glu Ser Trp Asn Gln Pro 
            180                 185                 190         


Arg Lys Leu Gly Arg Gln Met Ser Asp Gly Asp Gly Glu Arg Leu Phe 
        195                 200                 205             


Gln Asp Leu Tyr Pro Phe Ile Gln Gly Glu His Val Leu Asn Ser Gln 
    210                 215                 220                 


Asn Lys Gly Lys Ser Arg Ser Leu Pro Arg Val Leu Ser Pro Glu Ser 
225                 230                 235                 240 


Leu Ser Cys Thr Glu Ile Pro Ile Pro Leu Asn Glu Arg His Ser Pro 
                245                 250                 255     


Lys Met Pro Pro Tyr Pro Pro Thr Cys Ala Pro Asn Leu Asp Ser Thr 
            260                 265                 270         


Arg Asn Ser Glu Lys Ser Gly Cys Ser Ala Pro Phe Pro Arg Pro Lys 
        275                 280                 285             


Phe Gly Arg Pro Leu Lys Pro Pro Ser Tyr Ser Ser His Gln Gln Ser 
    290                 295                 300                 


Arg Gly Gly Ala Asp Ser Ser Asp Ser Gln Asp Ser Gln Gln Met Asp 
305                 310                 315                 320 


Ala Tyr Val Pro Arg His Glu Leu Cys Leu Ser Asp Pro Gly Leu Glu 
                325                 330                 335     


Pro Pro Val Tyr Val Pro Pro Pro Ser Tyr Arg Ser Pro Pro Gln Asn 
            340                 345                 350         


Ile Pro Asn Pro Tyr Leu Glu Asp Thr Val Pro Ile Asn Val Cys Gly 
        355                 360                 365             


Gly His Ser Gln Gln Gln Ser Pro Thr Glu Lys Ala Gly Ala Ser Gly 
    370                 375                 380                 


Gln Pro Pro Ser Gly Pro Pro Gly Thr Gly Asn Glu Tyr Gly Val Ser 
385                 390                 395                 400 


Pro Arg Leu Pro Gln Gly Leu Pro Ala His Pro Arg Pro Val Thr Ala 
                405                 410                 415     


Tyr Asp Gly Phe Val Gln Tyr Ile Pro Phe Asp Asp Pro Arg Leu Arg 
            420                 425                 430         


His Phe Lys Leu Ala Gln Pro Gln Gly Phe Cys Glu Asp Ile Lys Leu 
        435                 440                 445             


Asp Asp Lys Ser Tyr Asn Ser Ser Pro Val Thr Ala Gln Glu Pro Ala 
    450                 455                 460                 


His Gly Gly Met Gln Pro Asp Gly Ala Ile Trp Asn Pro Gln Ser Leu 
465                 470                 475                 480 


Ile Pro Pro Ser Gly Asp Glu Arg Gly Leu Val Leu Ala Asp Ser Ser 
                485                 490                 495     


Pro Arg Trp Leu Trp Gly Gln Pro Pro Gly Asp Gly Glu Asn Ser Gly 
            500                 505                 510         


Leu Pro Asn Gln Arg Asp Arg Cys Val Ala Arg Gly Gln Trp Pro Asp 
        515                 520                 525             


Val Arg Gly Ser Gln His Gly His Thr Gly Arg Gln Val Ser Ser Pro 
    530                 535                 540                 


Tyr Ser Gln Gly Glu Ser Thr Cys Glu Thr Gln Thr Lys Leu Lys Lys 
545                 550                 555                 560 


Phe Gln Thr Gly Thr Arg Thr Lys Lys Ser Ser Lys Lys Lys Met Asn 
                565                 570                 575     


Glu Thr Ile Phe Cys Leu Val Ser Ile Pro Val Lys Ser Glu Ser His 
            580                 585                 590         


Leu Pro Asp Arg Asp Met Asp Asn Asn Asp Leu Lys Pro Ser Ala Asp 
        595                 600                 605             


Gln Lys Asn Gly Ser Asp Lys Ser Pro Ala Leu Gln Glu Gln Ser Leu 
    610                 615                 620                 


Leu Ser Met Ser Ser Thr Asp Leu Glu Leu Gln Ala Leu Thr Gly Ser 
625                 630                 635                 640 


Met Gly Gly Arg Thr Glu Phe Gln Lys Gln Asp Leu Gly Glu Pro Glu 
                645                 650                 655     


Glu Asp Arg Gln Thr Asn Asp Leu Ser Phe Ile His Leu Thr Lys His 
            660                 665                 670         


Arg Glu Leu Lys His Ser Gly Ser Trp Pro Gly His Arg Tyr Arg Asp 
        675                 680                 685             


Gln Gln Thr Gln Thr Ser Phe Ser Glu Glu Pro Gln Ser Ser Gln Leu 
    690                 695                 700                 


Leu Pro Gly Ala Lys Leu Gly Gly Pro Ser Arg Ala Ala Leu Ser Pro 
705                 710                 715                 720 


Lys Cys Ser Asp Pro Ala Ala Ser Glu Ala Gln Thr His Thr Ala Phe 
                725                 730                 735     


Pro Thr Gly Asp His Lys Gln Arg Pro Ser Ala Arg Asn Leu Lys Gly 
            740                 745                 750         


His Arg Ser Leu Ser Pro Ser Ser Asn Ser Ala Phe Ser Arg Thr Ser 
        755                 760                 765             


Leu Ser Val Asp Gln Ala Pro Thr Pro Lys Ala Gly Arg Ser Gln Pro 
    770                 775                 780                 


Cys Val Asp Val His Gly Leu Gly Ala His Pro Gly Pro Lys Arg Glu 
785                 790                 795                 800 


Val Val Lys Gly Glu Pro Thr Gly Pro Cys Asn Ser Lys Gln Leu Phe 
                805                 810                 815     


Gly Gln Phe Leu Leu Lys Pro Val Ser Arg Arg Pro Trp Asp Leu Ile 
            820                 825                 830         


Ser Gln Leu Glu Ser Phe Asn Lys Glu Leu Gln Glu Glu Glu Glu Ser 
        835                 840                 845             


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Glu Ser Glu Ala 
    850                 855                 860                 


Glu Pro Gln Gln Glu Asn Arg Ala His Cys Arg Gln Glu Asp Val Gly 
865                 870                 875                 880 


Phe Arg Gly Asn Ser Pro Glu Met Arg Val Glu Pro Gln Pro Arg Met 
                885                 890                 895     


Trp Val Pro Glu Ser Pro Val Cys Arg Ser Gly Arg Gly Glu Ser Lys 
            900                 905                 910         


Ser Glu Ser Trp Ser Glu Glu Leu Gln Pro Gly His Pro Arg Ala Trp 
        915                 920                 925             


Pro Pro Ser Pro Gly Arg Phe Arg Val Glu Glu Gly Gly Gly Ala Pro 
    930                 935                 940                 


Phe Cys Ser Ala Asp Gly Ser Thr Ser Ala Glu Lys Arg His Leu Glu 
945                 950                 955                 960 


Val Ser Asn Gly Met Asp Glu Leu Ala Gly Ser Pro Phe Pro Val Thr 
                965                 970                 975     


Arg Met Ser Ser Arg Ser Ser Asp Ala Lys Pro Leu Pro Ala Ser Tyr 
            980                 985                 990         


Pro Ala Glu Pro Arg Glu Pro Gln  Glu Ser Pro Lys Ile  Thr Ser Ala 
        995                 1000                 1005             


Phe Ser  Ser Val Lys Pro Ser  Glu Ala Val Pro Arg  Lys Phe Asp 
    1010                 1015                 1020             


Ser Gly  Gly Glu Arg Gly Ala  Gly Leu Pro Leu Ser  Leu Ser Asn 
    1025                 1030                 1035             


Lys Asn  Arg Gly Leu Ser Ala  Pro Asp Leu Arg Ser  Val Gly Leu 
    1040                 1045                 1050             


Thr Pro  Gly Gln Glu Gln Gly  Ala Ser Glu Leu Glu  Gly Ser Leu 
    1055                 1060                 1065             


Gly Glu  Ala Ser Thr Ile Glu  Ile Pro Pro Gly Glu  Ser Leu Gln 
    1070                 1075                 1080             


Ala Arg  Ala Ala Arg Ile Leu  Gly Ile Glu Val Ala  Val Glu Ser 
    1085                 1090                 1095             


Leu Leu  Pro Gly Ile Arg Arg  Ala Gly Gln Asn Gln  Pro Ala Glu 
    1100                 1105                 1110             


Pro Asp  Ala Ser Ala Cys Thr  Pro Glu Ser Pro Gln  Glu Glu Leu 
    1115                 1120                 1125             


Leu Ser  Arg Pro Ala Pro Ala  Asp Val Pro Arg Val  Ser Thr Asp 
    1130                 1135                 1140             


Ala Phe  Tyr Gly Arg Arg Lys  Cys Gly Trp Thr Lys  Ser Pro Leu 
    1145                 1150                 1155             


Phe Val  Gly Asp Arg Asp Ser  Ala Arg Arg Ala Pro  Gln Ala Phe 
    1160                 1165                 1170             


Glu His  Ser Asp Val Asp Gly  Val Val Thr Ser Thr  Asp Pro Val 
    1175                 1180                 1185             


Pro Glu  Pro Glu Pro Ser Pro  Leu Glu Ser Lys Phe  Phe Glu Gln 
    1190                 1195                 1200             


Lys Asp  Val Glu Thr Lys Pro  Pro Phe Arg Ser Thr  Leu Phe His 
    1205                 1210                 1215             


Phe Val  Glu Arg Thr Pro Ser  Val Ala Gly Ser Glu  Lys Arg Leu 
    1220                 1225                 1230             


Arg Ser  Pro Ser Lys Val Ile  Glu Ser Leu Gln Glu  Lys Leu Ala 
    1235                 1240                 1245             


Ser Pro  Pro Arg Arg Ala Asp  Pro Asp Arg Leu Met  Arg Met Lys 
    1250                 1255                 1260             


Glu Val  Ser Ser Val Ser Arg  Met Arg Val Leu Ser  Phe Arg Asn 
    1265                 1270                 1275             


Ala Asp  Ser Gln Glu Asp Ala  Glu Glu Leu Lys Ala  Thr Thr Arg 
    1280                 1285                 1290             


Gly Gln  Ala Gly Leu Pro Gly  Gly Leu Val Ser Pro  Gly Ser Gly 
    1295                 1300                 1305             


Asp Arg  Ala Gln Arg Leu Gly  His Ser Leu Ser Val  Ser Lys Asp 
    1310                 1315                 1320             


Ser Ile  Ser Arg Glu Glu Lys  Glu His Pro Ala Ala  Gln Lys Glu 
    1325                 1330                 1335             


Lys Ser  Met Asp Gln Asp Phe  Trp Cys Pro Asp Ser  Tyr Asp Pro 
    1340                 1345                 1350             


Ser Arg  Val Glu Arg Val 
    1355                 


<210>  5857
<211>  1216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1468__Homo_sapiens__NP_065905

<400>  5857

Met Ala Ala Met Ala Pro Gly Gly Ser Gly Ser Gly Gly Gly Val Asn 
1               5                   10                  15      


Pro Phe Leu Ser Asp Ser Asp Glu Asp Asp Asp Glu Val Ala Ala Thr 
            20                  25                  30          


Glu Glu Arg Arg Ala Val Leu Arg Leu Gly Ala Gly Ser Gly Leu Asp 
        35                  40                  45              


Pro Gly Ser Ala Gly Ser Leu Ser Pro Gln Asp Pro Val Ala Leu Gly 
    50                  55                  60                  


Ser Ser Ala Arg Pro Gly Leu Pro Gly Glu Ala Ser Ala Ala Ala Val 
65                  70                  75                  80  


Ala Leu Gly Gly Thr Gly Glu Thr Pro Ala Arg Leu Ser Ile Asp Ala 
                85                  90                  95      


Ile Ala Ala Gln Leu Leu Arg Asp Gln Tyr Leu Leu Thr Ala Leu Glu 
            100                 105                 110         


Leu His Thr Glu Leu Leu Glu Ser Gly Arg Glu Leu Pro Arg Leu Arg 
        115                 120                 125             


Asp Tyr Phe Ser Asn Pro Gly Asn Phe Glu Arg Gln Ser Gly Thr Pro 
    130                 135                 140                 


Pro Gly Met Gly Ala Pro Gly Val Pro Gly Ala Ala Gly Val Gly Gly 
145                 150                 155                 160 


Ala Gly Gly Arg Glu Pro Ser Thr Ala Ser Gly Gly Gly Gln Leu Asn 
                165                 170                 175     


Arg Ala Gly Ser Ile Ser Thr Leu Asp Ser Leu Asp Phe Ala Arg Tyr 
            180                 185                 190         


Ser Asp Asp Gly Asn Arg Glu Thr Asp Glu Lys Val Ala Val Leu Glu 
        195                 200                 205             


Phe Glu Leu Arg Lys Ala Lys Glu Thr Ile Gln Ala Leu Arg Ala Asn 
    210                 215                 220                 


Leu Thr Lys Ala Ala Glu His Glu Val Pro Leu Gln Glu Arg Lys Asn 
225                 230                 235                 240 


Tyr Lys Ser Ser Pro Glu Ile Gln Glu Pro Ile Lys Pro Leu Glu Lys 
                245                 250                 255     


Arg Ala Leu Asn Phe Leu Val Asn Glu Phe Leu Leu Lys Asn Asn Tyr 
            260                 265                 270         


Lys Leu Thr Ser Ile Thr Phe Ser Asp Glu Asn Asp Asp Gln Asp Phe 
        275                 280                 285             


Glu Leu Trp Asp Asp Val Gly Leu Asn Ile Pro Lys Pro Pro Asp Leu 
    290                 295                 300                 


Leu Gln Leu Tyr Arg Asp Phe Gly Asn His Gln Val Thr Gly Lys Asp 
305                 310                 315                 320 


Leu Val Asp Val Ala Ser Gly Val Glu Glu Asp Glu Leu Glu Ala Leu 
                325                 330                 335     


Thr Pro Ile Ile Ser Asn Leu Pro Pro Thr Leu Glu Thr Pro Gln Pro 
            340                 345                 350         


Ala Glu Asn Ser Met Leu Val Gln Lys Leu Glu Asp Lys Ile Ser Leu 
        355                 360                 365             


Leu Asn Ser Glu Lys Trp Ser Leu Met Glu Gln Ile Arg Arg Leu Lys 
    370                 375                 380                 


Ser Glu Met Asp Phe Leu Lys Asn Glu His Phe Ala Ile Pro Ala Val 
385                 390                 395                 400 


Cys Asp Ser Val Gln Pro Pro Leu Asp Gln Leu Pro His Lys Asp Ser 
                405                 410                 415     


Glu Asp Ser Gly Gln His Pro Asp Val Asn Ser Ser Asp Lys Gly Lys 
            420                 425                 430         


Asn Thr Asp Ile His Leu Ser Ile Ser Asp Glu Ala Asp Ser Thr Ile 
        435                 440                 445             


Pro Lys Glu Asn Ser Pro Asn Ser Phe Pro Arg Arg Glu Arg Glu Gly 
    450                 455                 460                 


Met Pro Pro Ser Ser Leu Ser Ser Lys Lys Thr Val His Phe Asp Lys 
465                 470                 475                 480 


Pro Asn Arg Lys Leu Ser Pro Ala Phe His Gln Ala Leu Leu Ser Phe 
                485                 490                 495     


Cys Arg Met Ser Ala Asp Ser Arg Leu Gly Tyr Glu Val Ser Arg Ile 
            500                 505                 510         


Ala Asp Ser Glu Lys Ser Val Met Leu Met Leu Gly Arg Cys Leu Pro 
        515                 520                 525             


His Ile Val Pro Asn Val Leu Leu Ala Lys Arg Glu Glu Leu Ile Pro 
    530                 535                 540                 


Leu Ile Leu Cys Thr Ala Cys Leu His Pro Glu Pro Lys Glu Arg Asp 
545                 550                 555                 560 


Gln Leu Leu His Ile Leu Phe Asn Leu Ile Lys Arg Pro Asp Asp Glu 
                565                 570                 575     


Gln Arg Gln Met Ile Leu Thr Gly Cys Val Ala Phe Ala Arg His Val 
            580                 585                 590         


Gly Pro Thr Arg Val Glu Ala Glu Leu Leu Pro Gln Cys Trp Glu Gln 
        595                 600                 605             


Ile Asn His Lys Tyr Pro Glu Arg Arg Leu Leu Val Ala Glu Ser Cys 
    610                 615                 620                 


Gly Ala Leu Ala Pro Tyr Leu Pro Lys Glu Ile Arg Ser Ser Leu Val 
625                 630                 635                 640 


Leu Ser Met Leu Gln Gln Met Leu Met Glu Asp Lys Ala Asp Leu Val 
                645                 650                 655     


Arg Glu Ala Val Ile Lys Ser Leu Gly Ile Ile Met Gly Tyr Ile Asp 
            660                 665                 670         


Asp Pro Asp Lys Tyr His Gln Gly Phe Glu Leu Leu Leu Ser Ala Leu 
        675                 680                 685             


Gly Asp Pro Ser Glu Arg Val Val Ser Ala Thr His Gln Val Phe Leu 
    690                 695                 700                 


Pro Ala Tyr Ala Ala Trp Thr Thr Glu Leu Gly Asn Leu Gln Ser His 
705                 710                 715                 720 


Leu Ile Leu Thr Leu Leu Asn Lys Ile Glu Lys Leu Leu Arg Glu Gly 
                725                 730                 735     


Glu His Gly Leu Asp Glu His Lys Leu His Met Tyr Leu Ser Ala Leu 
            740                 745                 750         


Gln Ser Leu Ile Pro Ser Leu Phe Ala Leu Val Leu Gln Asn Ala Pro 
        755                 760                 765             


Phe Ser Ser Lys Ala Lys Leu His Gly Glu Val Pro Gln Ile Glu Val 
    770                 775                 780                 


Thr Arg Phe Pro Arg Pro Met Ser Pro Leu Gln Asp Val Ser Thr Ile 
785                 790                 795                 800 


Ile Gly Ser Arg Glu Gln Leu Ala Val Leu Leu Gln Leu Tyr Asp Tyr 
                805                 810                 815     


Gln Leu Glu Gln Glu Gly Thr Thr Gly Trp Glu Ser Leu Leu Trp Val 
            820                 825                 830         


Val Asn Gln Leu Leu Pro Gln Leu Ile Glu Ile Val Gly Lys Ile Asn 
        835                 840                 845             


Val Thr Ser Thr Ala Cys Val His Glu Phe Ser Arg Phe Phe Trp Arg 
    850                 855                 860                 


Leu Cys Arg Thr Phe Gly Lys Ile Phe Thr Asn Thr Lys Val Lys Pro 
865                 870                 875                 880 


Gln Phe Gln Glu Ile Leu Arg Leu Ser Glu Glu Asn Ile Asp Ser Ser 
                885                 890                 895     


Ala Gly Asn Gly Val Leu Thr Lys Ala Thr Val Pro Ile Tyr Ala Thr 
            900                 905                 910         


Gly Val Leu Thr Cys Tyr Ile Gln Glu Glu Asp Arg Lys Leu Leu Val 
        915                 920                 925             


Gly Phe Leu Glu Asp Val Met Thr Leu Leu Ser Leu Ser His Ala Pro 
    930                 935                 940                 


Leu Asp Ser Leu Lys Ala Ser Phe Val Glu Leu Gly Ala Asn Pro Ala 
945                 950                 955                 960 


Tyr His Glu Leu Leu Leu Thr Val Leu Trp Tyr Gly Val Val His Thr 
                965                 970                 975     


Ser Ala Leu Val Arg Cys Thr Ala Ala Arg Met Phe Glu Leu Thr Leu 
            980                 985                 990         


Arg Gly Met Ser Glu Ala Leu Val  Asp Lys Arg Val Ala  Pro Ala Leu 
        995                 1000                 1005             


Val Thr  Leu Ser Ser Asp Pro  Glu Phe Ser Val Arg  Ile Ala Thr 
    1010                 1015                 1020             


Ile Pro  Ala Phe Gly Thr Ile  Met Glu Thr Val Ile  Gln Arg Glu 
    1025                 1030                 1035             


Leu Leu  Glu Arg Val Lys Met  Gln Leu Ala Ser Phe  Leu Glu Asp 
    1040                 1045                 1050             


Pro Gln  Tyr Gln Asp Gln His  Ser Leu His Thr Glu  Ile Ile Lys 
    1055                 1060                 1065             


Thr Phe  Gly Arg Val Gly Pro  Asn Ala Glu Pro Arg  Phe Arg Asp 
    1070                 1075                 1080             


Glu Phe  Val Ile Pro His Leu  His Lys Leu Ala Leu  Val Asn Asn 
    1085                 1090                 1095             


Leu Gln  Ile Val Asp Ser Lys  Arg Leu Asp Ile Ala  Thr His Leu 
    1100                 1105                 1110             


Phe Glu  Ala Tyr Ser Ala Leu  Ser Cys Cys Phe Ile  Ser Glu Asp 
    1115                 1120                 1125             


Leu Met  Val Asn His Phe Leu  Pro Gly Leu Arg Cys  Leu Arg Thr 
    1130                 1135                 1140             


Asp Met  Glu His Leu Ser Pro  Glu His Glu Val Ile  Leu Ser Ser 
    1145                 1150                 1155             


Met Ile  Lys Glu Cys Glu Gln  Lys Val Glu Asn Lys  Thr Val Gln 
    1160                 1165                 1170             


Glu Pro  Gln Gly Ser Met Ser  Ile Ala Ala Ser Leu  Val Ser Glu 
    1175                 1180                 1185             


Asp Thr  Lys Thr Lys Phe Leu  Asn Lys Met Gly Gln  Leu Thr Thr 
    1190                 1195                 1200             


Ser Gly  Ala Met Leu Ala Asn  Val Phe Gln Arg Lys  Lys 
    1205                 1210                 1215     


<210>  5858
<211>  905
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1524__Homo_sapiens__NP_065941

<400>  5858

Met Asp Ser Thr Ala Cys Leu Lys Ser Leu Leu Leu Thr Val Ser Gln 
1               5                   10                  15      


Tyr Lys Ala Val Lys Ser Glu Ala Asn Ala Thr Gln Leu Leu Arg His 
            20                  25                  30          


Leu Glu Val Ile Ser Gly Gln Lys Leu Thr Arg Leu Phe Thr Ser Asn 
        35                  40                  45              


Gln Ile Leu Thr Ser Glu Cys Leu Ser Cys Leu Val Glu Leu Leu Glu 
    50                  55                  60                  


Asp Pro Asn Ile Ser Ala Ser Leu Ile Leu Ser Ile Ile Gly Leu Leu 
65                  70                  75                  80  


Ser Gln Leu Ala Val Asp Ile Glu Thr Arg Asp Cys Leu Gln Asn Thr 
                85                  90                  95      


Tyr Asn Leu Asn Ser Val Leu Ala Gly Val Val Cys Arg Ser Ser His 
            100                 105                 110         


Thr Asp Ser Val Phe Leu Gln Cys Ile Gln Leu Leu Gln Lys Leu Thr 
        115                 120                 125             


Tyr Asn Val Lys Ile Phe Tyr Ser Gly Ala Asn Ile Asp Glu Leu Ile 
    130                 135                 140                 


Thr Phe Leu Ile Asp His Ile Gln Ser Ser Glu Asp Glu Leu Lys Met 
145                 150                 155                 160 


Pro Cys Leu Gly Leu Leu Ala Asn Leu Cys Arg His Asn Leu Ser Val 
                165                 170                 175     


Gln Thr His Ile Lys Thr Leu Ser Asn Val Lys Ser Phe Tyr Arg Thr 
            180                 185                 190         


Leu Ile Thr Leu Leu Ala His Ser Ser Leu Thr Val Val Val Phe Ala 
        195                 200                 205             


Leu Ser Ile Leu Ser Ser Leu Thr Leu Asn Glu Glu Val Gly Glu Lys 
    210                 215                 220                 


Leu Phe His Ala Arg Asn Ile His Gln Thr Phe Gln Leu Ile Phe Asn 
225                 230                 235                 240 


Ile Leu Ile Asn Gly Asp Gly Thr Leu Thr Arg Lys Tyr Ser Val Asp 
                245                 250                 255     


Leu Leu Met Asp Leu Leu Lys Asn Pro Lys Ile Ala Asp Tyr Leu Thr 
            260                 265                 270         


Arg Tyr Glu His Phe Ser Ser Cys Leu His Gln Val Leu Gly Leu Leu 
        275                 280                 285             


Asn Gly Lys Asp Pro Asp Ser Ser Ser Lys Val Leu Glu Leu Leu Leu 
    290                 295                 300                 


Ala Phe Cys Ser Val Thr Gln Leu Arg His Met Leu Thr Gln Met Met 
305                 310                 315                 320 


Phe Glu Gln Ser Pro Pro Gly Ser Ala Thr Leu Gly Ser His Thr Lys 
                325                 330                 335     


Cys Leu Glu Pro Thr Val Ala Leu Leu Arg Trp Leu Ser Gln Pro Leu 
            340                 345                 350         


Asp Gly Ser Glu Asn Cys Ser Val Leu Ala Leu Glu Leu Phe Lys Glu 
        355                 360                 365             


Ile Phe Glu Asp Val Ile Asp Ala Ala Asn Cys Ser Ser Ala Asp Arg 
    370                 375                 380                 


Phe Val Thr Leu Leu Leu Pro Thr Ile Leu Asp Gln Leu Gln Phe Thr 
385                 390                 395                 400 


Glu Gln Asn Leu Asp Glu Ala Leu Thr Arg Lys Lys Cys Glu Arg Ile 
                405                 410                 415     


Ala Lys Ala Ile Glu Val Leu Leu Thr Leu Cys Gly Asp Asp Thr Leu 
            420                 425                 430         


Lys Met His Ile Ala Lys Ile Leu Thr Thr Val Lys Cys Thr Thr Leu 
        435                 440                 445             


Ile Glu Gln Gln Phe Thr Tyr Gly Lys Ile Asp Leu Gly Phe Gly Thr 
    450                 455                 460                 


Lys Val Ala Asp Ser Glu Leu Cys Lys Leu Ala Ala Asp Val Ile Leu 
465                 470                 475                 480 


Lys Thr Leu Asp Leu Ile Asn Lys Leu Lys Pro Leu Val Pro Gly Met 
                485                 490                 495     


Glu Val Ser Phe Tyr Lys Ile Leu Gln Asp Pro Arg Leu Ile Thr Pro 
            500                 505                 510         


Leu Ala Phe Ala Leu Thr Ser Asp Asn Arg Glu Gln Val Gln Ser Gly 
        515                 520                 525             


Leu Arg Ile Leu Leu Glu Ala Ala Pro Leu Pro Asp Phe Pro Ala Leu 
    530                 535                 540                 


Val Leu Gly Glu Ser Ile Ala Ala Asn Asn Ala Tyr Arg Gln Gln Glu 
545                 550                 555                 560 


Thr Glu His Ile Pro Arg Lys Met Pro Trp Gln Ser Ser Asn His Ser 
                565                 570                 575     


Phe Pro Thr Ser Ile Lys Cys Leu Thr Pro His Leu Lys Asp Gly Val 
            580                 585                 590         


Pro Gly Leu Asn Ile Glu Glu Leu Ile Glu Lys Leu Gln Ser Gly Met 
        595                 600                 605             


Val Val Lys Asp Gln Ile Cys Asp Val Arg Ile Ser Asp Ile Met Asp 
    610                 615                 620                 


Val Tyr Glu Met Lys Leu Ser Thr Leu Ala Ser Lys Glu Ser Arg Leu 
625                 630                 635                 640 


Gln Asp Leu Leu Glu Thr Lys Ala Leu Ala Leu Ala Gln Ala Asp Arg 
                645                 650                 655     


Leu Ile Ala Gln His Arg Cys Gln Arg Thr Gln Ala Glu Thr Glu Ala 
            660                 665                 670         


Arg Thr Leu Ala Ser Met Leu Arg Glu Val Glu Arg Lys Asn Glu Glu 
        675                 680                 685             


Leu Ser Val Leu Leu Lys Ala Gln Gln Val Glu Ser Glu Arg Ala Gln 
    690                 695                 700                 


Ser Asp Ile Glu His Leu Phe Gln His Asn Arg Lys Leu Glu Ser Val 
705                 710                 715                 720 


Ala Glu Glu His Glu Ile Leu Thr Lys Ser Tyr Met Glu Leu Leu Gln 
                725                 730                 735     


Arg Asn Glu Ser Thr Glu Lys Lys Asn Lys Asp Leu Gln Ile Thr Cys 
            740                 745                 750         


Asp Ser Leu Asn Lys Gln Ile Glu Thr Val Lys Lys Leu Asn Glu Ser 
        755                 760                 765             


Leu Lys Glu Gln Asn Glu Lys Ser Ile Ala Gln Leu Ile Glu Lys Glu 
    770                 775                 780                 


Glu Gln Arg Lys Glu Val Gln Asn Gln Leu Val Asp Arg Glu His Lys 
785                 790                 795                 800 


Leu Ala Asn Leu His Gln Lys Thr Lys Val Gln Glu Glu Lys Ile Lys 
                805                 810                 815     


Thr Leu Gln Lys Glu Arg Glu Asp Lys Glu Glu Thr Ile Asp Ile Leu 
            820                 825                 830         


Arg Lys Glu Leu Ser Arg Thr Glu Gln Ile Arg Lys Glu Leu Ser Ile 
        835                 840                 845             


Lys Ala Ser Ser Leu Glu Val Gln Lys Ala Gln Leu Glu Gly Arg Leu 
    850                 855                 860                 


Glu Glu Lys Glu Ser Leu Val Lys Leu Gln Gln Glu Glu Leu Asn Lys 
865                 870                 875                 880 


His Ser His Met Ile Ala Met Ile His Ser Leu Ser Gly Gly Lys Ile 
                885                 890                 895     


Asn Pro Glu Thr Val Asn Leu Ser Ile 
            900                 905 


<210>  5859
<211>  1950
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1549__Homo_sapiens__NP_001158137

<400>  5859

Met Pro Gly Ala Arg Arg Arg Arg Arg Gly Ala Ala Met Glu Gly Lys 
1               5                   10                  15      


Pro Arg Ala Gly Val Ala Leu Ala Pro Gly Pro Ser Gly Arg Arg Pro 
            20                  25                  30          


Ser Ala Arg Cys Ala Arg Arg Arg Arg Pro Gly Leu Leu Leu Pro Gly 
        35                  40                  45              


Leu Trp Leu Leu Leu Leu Ala Arg Pro Ala Ser Cys Ala Pro Asp Glu 
    50                  55                  60                  


Leu Ser Pro Glu Gln His Asn Leu Ser Leu Tyr Ser Met Glu Leu Val 
65                  70                  75                  80  


Leu Lys Lys Ser Thr Gly His Ser Ala Ala Gln Val Ala Leu Thr Glu 
                85                  90                  95      


Thr Ala Pro Gly Ser Gln His Ser Ser Pro Leu His Val Thr Ala Pro 
            100                 105                 110         


Pro Ser Ala Thr Thr Phe Asp Thr Ala Phe Phe Asn Gln Gly Lys Gln 
        115                 120                 125             


Thr Lys Ser Thr Ala Asp Pro Ser Ile Phe Val Ala Thr Tyr Val Ser 
    130                 135                 140                 


Val Thr Ser Lys Glu Val Ala Val Asn Asp Asp Glu Met Asp Asn Phe 
145                 150                 155                 160 


Leu Pro Asp Thr His Trp Thr Thr Pro Arg Met Val Ser Pro Ile Gln 
                165                 170                 175     


Tyr Ile Thr Val Ser Pro Pro Gly Leu Pro Arg Glu Ala Leu Glu Pro 
            180                 185                 190         


Met Leu Thr Pro Ser Leu Pro Met Val Ser Leu Gln Asp Glu Glu Val 
        195                 200                 205             


Thr Ser Gly Trp Gln Asn Thr Thr Arg Gln Pro Ala Ala Tyr Ala Glu 
    210                 215                 220                 


Ser Ala Ser His Phe His Thr Phe Arg Ser Ala Phe Arg Thr Ser Glu 
225                 230                 235                 240 


Gly Ile Val Pro Thr Pro Gly Arg Asn Leu Val Leu Tyr Pro Thr Asp 
                245                 250                 255     


Ala Tyr Ser His Leu Ser Ser Arg Thr Leu Pro Glu Ile Val Ala Ser 
            260                 265                 270         


Leu Thr Glu Gly Val Glu Thr Thr Leu Phe Leu Ser Ser Arg Ser Leu 
        275                 280                 285             


Met Pro Gln Pro Leu Gly Asp Gly Ile Thr Ile Pro Leu Pro Ser Leu 
    290                 295                 300                 


Gly Glu Val Ser Gln Pro Pro Glu Glu Val Trp Ala Thr Ser Ala Asp 
305                 310                 315                 320 


Arg Tyr Thr Asp Val Thr Thr Val Leu Ser Gln Ser Leu Glu Glu Thr 
                325                 330                 335     


Ile Ser Pro Arg Thr Tyr Pro Thr Val Thr Ala Ser His Ala Ala Leu 
            340                 345                 350         


Ala Phe Ser Arg Thr His Ser Pro Leu Leu Ser Thr Pro Leu Ala Phe 
        355                 360                 365             


Ala Ser Ser Ala Ser Pro Thr Asp Val Ser Ser Asn Pro Phe Leu Pro 
    370                 375                 380                 


Ser Asp Ser Ser Lys Thr Ser Glu Leu His Ser Asn Ser Ala Leu Pro 
385                 390                 395                 400 


Gly Pro Val Asp Asn Thr His Ile Leu Ser Pro Val Ser Ser Phe Arg 
                405                 410                 415     


Pro Tyr Thr Trp Cys Ala Ala Cys Thr Val Pro Ser Pro Gln Gln Val 
            420                 425                 430         


Leu Ala Thr Ser Leu Met Glu Lys Asp Val Gly Ser Gly Asp Gly Ala 
        435                 440                 445             


Glu Thr Leu Cys Met Thr Val Leu Glu Glu Ser Ser Ile Ser Leu Met 
    450                 455                 460                 


Ser Ser Val Val Ala Asp Phe Ser Glu Phe Glu Glu Asp Pro Gln Val 
465                 470                 475                 480 


Phe Asn Thr Leu Phe Pro Ser Arg Pro Ile Val Pro Leu Ser Ser Arg 
                485                 490                 495     


Ser Met Glu Ile Ser Glu Thr Ser Val Gly Ile Ser Ala Glu Val Asp 
            500                 505                 510         


Met Ser Ser Val Thr Thr Thr Gln Val Pro Pro Ala His Gly Arg Leu 
        515                 520                 525             


Ser Val Pro Ala Ser Leu Asp Pro Thr Ala Gly Ser Leu Ser Val Ala 
    530                 535                 540                 


Glu Thr Gln Val Thr Pro Ser Ser Val Thr Thr Ala Phe Phe Ser Val 
545                 550                 555                 560 


Ile Thr Ser Ile Leu Leu Asp Ser Ser Phe Ser Val Ile Ala Asn Lys 
                565                 570                 575     


Asn Thr Pro Ser Leu Ala Val Arg Asp Pro Ser Val Phe Thr Pro Tyr 
            580                 585                 590         


Ser Leu Val Pro Ser Val Glu Ser Ser Leu Phe Ser Asp Gln Glu Arg 
        595                 600                 605             


Ser Ser Phe Ser Glu His Lys Pro Arg Gly Ala Leu Asp Phe Ala Ser 
    610                 615                 620                 


Ser Phe Phe Ser Thr Pro Pro Leu Glu Leu Ser Gly Ser Ile Ser Ser 
625                 630                 635                 640 


Pro Ser Glu Ala Pro Ala Ser Leu Ser Leu Met Pro Ser Asp Leu Ser 
                645                 650                 655     


Pro Phe Thr Ser Gln Ser Phe Ser Pro Leu Val Glu Thr Phe Thr Leu 
            660                 665                 670         


Phe Asp Ser Ser Asp Leu Gln Ser Ser Gln Leu Ser Leu Pro Ser Ser 
        675                 680                 685             


Thr Asn Leu Glu Phe Ser Gln Leu Gln Pro Ser Ser Glu Leu Pro Leu 
    690                 695                 700                 


Asn Thr Ile Met Leu Leu Pro Ser Arg Ser Glu Val Ser Pro Trp Ser 
705                 710                 715                 720 


Ser Phe Pro Ser Asp Ser Leu Glu Phe Val Glu Ala Ser Thr Val Ser 
                725                 730                 735     


Leu Thr Asp Ser Glu Ala His Phe Thr Ser Ala Phe Ile Glu Thr Thr 
            740                 745                 750         


Ser Tyr Leu Glu Ser Ser Leu Ile Ser His Glu Ser Ala Val Thr Ala 
        755                 760                 765             


Leu Val Pro Pro Gly Ser Glu Ser Phe Asp Ile Leu Thr Ala Gly Ile 
    770                 775                 780                 


Gln Ala Thr Ser Pro Leu Thr Thr Val His Thr Thr Pro Ile Leu Thr 
785                 790                 795                 800 


Glu Ser Ser Leu Phe Ser Thr Leu Thr Pro Pro Asp Asp Gln Ile Ser 
                805                 810                 815     


Ala Leu Asp Gly His Val Ser Val Leu Ala Ser Phe Ser Lys Ala Ile 
            820                 825                 830         


Pro Thr Gly Thr Val Leu Ile Thr Asp Ala Tyr Leu Pro Ser Gly Ser 
        835                 840                 845             


Ser Phe Val Ser Glu Ala Thr Pro Phe Pro Leu Pro Thr Glu Leu Thr 
    850                 855                 860                 


Val Val Gly Pro Ser Leu Thr Pro Thr Glu Val Pro Leu Asn Thr Ser 
865                 870                 875                 880 


Thr Glu Val Ser Thr Thr Ser Thr Gly Ala Ala Thr Gly Gly Pro Leu 
                885                 890                 895     


Asp Ser Thr Leu Met Gly Asp Ala Ala Ser Gln Ser Pro Pro Glu Ser 
            900                 905                 910         


Ser Ala Ala Pro Pro Leu Pro Ser Leu Arg Pro Val Thr Ala Phe Thr 
        915                 920                 925             


Leu Glu Ala Thr Val Asp Thr Pro Thr Leu Ala Thr Ala Lys Pro Pro 
    930                 935                 940                 


Tyr Val Cys Asp Ile Thr Val Pro Asp Ala Tyr Leu Ile Thr Thr Val 
945                 950                 955                 960 


Leu Ala Arg Arg Ala Val Gln Glu Tyr Ile Ile Thr Ala Ile Lys Glu 
                965                 970                 975     


Val Leu Arg Ile His Phe Asn Arg Ala Val Glu Leu Lys Val Tyr Glu 
            980                 985                 990         


Leu Phe Thr Asp Phe Thr Phe Leu  Val Thr Ser Gly Pro  Phe Val Tyr 
        995                 1000                 1005             


Thr Ala  Ile Ser Val Ile Asn  Val Leu Ile Asn Ser  Lys Leu Val 
    1010                 1015                 1020             


Arg Asp  Gln Thr Pro Leu Ile  Leu Ser Val Lys Pro  Ser Phe Leu 
    1025                 1030                 1035             


Val Pro  Glu Ser Arg Phe Gln  Val Gln Thr Val Leu  Gln Phe Val 
    1040                 1045                 1050             


Pro Pro  Ser Val Asp Thr Gly  Phe Cys Asn Phe Thr  Gln Arg Ile 
    1055                 1060                 1065             


Glu Lys  Gly Leu Met Thr Ala  Leu Phe Glu Val Arg  Lys His His 
    1070                 1075                 1080             


Gln Gly  Thr Tyr Asn Leu Thr  Val Gln Ile Leu Asn  Ile Thr Ile 
    1085                 1090                 1095             


Ser Ser  Ser Arg Val Thr Pro  Arg Arg Gly Pro Val  Asn Ile Ile 
    1100                 1105                 1110             


Phe Ala  Val Lys Ser Thr Gln  Gly Phe Leu Asn Gly  Ser Glu Val 
    1115                 1120                 1125             


Ser Glu  Leu Leu Arg Asn Leu  Ser Val Val Glu Phe  Ser Phe Tyr 
    1130                 1135                 1140             


Leu Gly  Tyr Pro Val Leu Gln  Ile Ala Glu Pro Phe  Gln Tyr Pro 
    1145                 1150                 1155             


Gln Leu  Asn Leu Ser Gln Leu  Leu Lys Ser Ser Trp  Val Arg Thr 
    1160                 1165                 1170             


Val Leu  Leu Gly Val Met Glu  Lys Gln Leu Gln Asn  Glu Val Phe 
    1175                 1180                 1185             


Gln Ala  Glu Met Glu Arg Lys  Leu Ala Gln Leu Leu  Ser Glu Val 
    1190                 1195                 1200             


Ser Thr  Arg Arg Arg Met Trp  Arg Arg Ala Thr Val  Ala Ala Gly 
    1205                 1210                 1215             


Asn Ser  Val Val Gln Val Val  Asn Val Ser Arg Leu  Glu Gly Asp 
    1220                 1225                 1230             


Asp Asn  Pro Val Gln Leu Ile  Tyr Phe Val Glu Asp  Gln Asp Gly 
    1235                 1240                 1245             


Glu Arg  Leu Ser Ala Val Lys  Ser Ser Asp Leu Ile  Asn Lys Met 
    1250                 1255                 1260             


Asp Leu  Gln Arg Ala Ala Ile  Ile Leu Gly Tyr Arg  Ile Gln Gly 
    1265                 1270                 1275             


Val Ile  Ala Gln Pro Val Asp  Arg Val Lys Arg Pro  Ser Pro Glu 
    1280                 1285                 1290             


Ser Gln  Ser Asn Asn Leu Trp  Val Ile Val Gly Val  Val Ile Pro 
    1295                 1300                 1305             


Val Leu  Val Val Met Val Ile  Val Val Ile Leu Tyr  Trp Lys Leu 
    1310                 1315                 1320             


Cys Arg  Thr Asp Lys Leu Asp  Phe Gln Pro Asp Thr  Val Ala Asn 
    1325                 1330                 1335             


Ile Gln  Gln Arg Gln Lys Leu  Gln Ile Pro Ser Val  Lys Gly Phe 
    1340                 1345                 1350             


Asp Phe  Ala Lys Gln His Leu  Gly Gln His Asn Lys  Asp Asp Ile 
    1355                 1360                 1365             


Leu Ile  Ile His Glu Pro Ala  Pro Leu Pro Gly Pro  Leu Lys Asp 
    1370                 1375                 1380             


His Thr  Thr Pro Ser Glu Asn  Gly Asp Val Pro Ser  Pro Lys Ser 
    1385                 1390                 1395             


Lys Ile  Pro Ser Lys Asn Val  Arg His Arg Gly Arg  Val Ser Pro 
    1400                 1405                 1410             


Ser Asp  Ala Asp Ser Thr Val  Ser Glu Glu Ser Ser  Glu Arg Asp 
    1415                 1420                 1425             


Ala Gly  Asp Lys Thr Pro Gly  Ala Val Asn Asp Gly  Arg Ser His 
    1430                 1435                 1440             


Arg Ala  Pro Gln Ser Gly Pro  Pro Leu Pro Ser Ser  Gly Asn Glu 
    1445                 1450                 1455             


Gln His  Ser Ser Ala Ser Ile  Phe Glu His Val Asp  Arg Ile Ser 
    1460                 1465                 1470             


Arg Pro  Pro Glu Ala Ser Arg  Arg Val Pro Ser Lys  Ile Gln Leu 
    1475                 1480                 1485             


Ile Ala  Met Gln Pro Ile Pro  Ala Pro Pro Val Gln  Arg Pro Ser 
    1490                 1495                 1500             


Pro Ala  Asp Arg Val Ala Glu  Ser Asn Lys Ile Asn  Lys Glu Ile 
    1505                 1510                 1515             


Gln Thr  Ala Leu Arg His Lys  Ser Glu Ile Glu His  His Arg Asn 
    1520                 1525                 1530             


Lys Ile  Arg Leu Arg Ala Lys  Arg Arg Gly His Tyr  Glu Phe Pro 
    1535                 1540                 1545             


Val Val  Asp Asp Leu Ser Ser  Gly Asp Thr Lys Glu  Arg His Arg 
    1550                 1555                 1560             


Val Tyr  Arg Arg Ala Gln Met  Gln Ile Asp Lys Ile  Leu Asp Pro 
    1565                 1570                 1575             


Thr Ala  Ser Val Pro Ser Val  Phe Ile Glu Pro Arg  Lys Ser Ser 
    1580                 1585                 1590             


Arg Ile  Lys Arg Ser Pro Lys  Pro Arg Arg Lys His  Gln Val Asn 
    1595                 1600                 1605             


Gly Cys  Pro Ala Asp Ala Glu  Lys Asp Arg Leu Ile  Thr Thr Asp 
    1610                 1615                 1620             


Ser Asp  Gly Thr Tyr Arg Arg  Pro Pro Gly Val His  Asn Ser Ala 
    1625                 1630                 1635             


Tyr Ile  Gly Cys Pro Ser Asp  Pro Asp Leu Pro Ala  Asp Val Gln 
    1640                 1645                 1650             


Thr Pro  Ser Ser Val Glu Leu  Gly Arg Tyr Pro Ala  Leu Pro Phe 
    1655                 1660                 1665             


Pro Ala  Ser Gln Tyr Ile Pro  Pro Gln Pro Ser Ile  Glu Glu Ala 
    1670                 1675                 1680             


Arg Gln  Thr Met His Ser Leu  Leu Asp Asp Ala Phe  Ala Leu Val 
    1685                 1690                 1695             


Ala Pro  Ser Ser Gln Pro Ala  Ser Thr Ala Gly Val  Gly Pro Gly 
    1700                 1705                 1710             


Val Pro  Pro Gly Leu Pro Ala  Asn Ser Thr Pro Ser  Gln Glu Glu 
    1715                 1720                 1725             


Arg Arg  Ala Thr Gln Trp Gly  Ser Phe Tyr Ser Pro  Ala Gln Thr 
    1730                 1735                 1740             


Ala Asn  Asn Pro Cys Ser Arg  Tyr Glu Asp Tyr Gly  Met Thr Pro 
    1745                 1750                 1755             


Pro Thr  Gly Pro Leu Pro Arg  Pro Gly Phe Gly Pro  Gly Leu Leu 
    1760                 1765                 1770             


Gln Ser  Thr Glu Leu Val Pro  Pro Asp Pro Gln Gln  Pro Gln Ala 
    1775                 1780                 1785             


Ser Ala  Glu Ala Pro Phe Ala  Ala Arg Gly Ile Tyr  Ser Glu Glu 
    1790                 1795                 1800             


Met Pro  Ser Val Ala Arg Pro  Arg Pro Val Gly Gly  Thr Thr Gly 
    1805                 1810                 1815             


Ser Gln  Ile Gln His Leu Thr  Gln Val Gly Ile Ala  Ser Arg Ile 
    1820                 1825                 1830             


Gly Ala  Gln Pro Val Glu Ile  Pro Pro Ser Arg Gly  Ser Gln Tyr 
    1835                 1840                 1845             


Gly Gly  Pro Gly Trp Pro Ser  Tyr Gly Glu Asp Glu  Ala Gly Arg 
    1850                 1855                 1860             


Arg Glu  Ala Thr His Met Leu  Gly His Gln Glu Tyr  Ser Ser Ser 
    1865                 1870                 1875             


Pro Leu  Phe Gln Val Pro Arg  Thr Ser Gly Arg Glu  Pro Ser Ala 
    1880                 1885                 1890             


Pro Ser  Gly Asn Leu Pro His  Arg Gly Leu Gln Gly  Pro Gly Leu 
    1895                 1900                 1905             


Gly Tyr  Pro Thr Ser Ser Thr  Glu Asp Leu Gln Pro  Gly His Ser 
    1910                 1915                 1920             


Ser Ala  Ser Leu Ile Lys Ala  Ile Arg Glu Glu Leu  Leu Arg Leu 
    1925                 1930                 1935             


Ser Gln  Lys Gln Ser Thr Val  Gln Asn Phe His Ser  
    1940                 1945                 1950 


<210>  5860
<211>  1747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1551__Homo_sapiens__XP_005253462

<400>  5860

Met Asn Trp Asn Glu Lys Pro Lys Ser Ala Thr Leu Pro Pro Leu Tyr 
1               5                   10                  15      


Pro Lys Ser Gln Pro Pro Phe Leu His Gln Ser Leu Ile Asn Gln Ile 
            20                  25                  30          


Thr Thr Thr Ser Gln Ser Ser Phe Ser Tyr Pro Gly Ser Asn Gln Glu 
        35                  40                  45              


Ala Cys Met Tyr Pro Gly Asn Ser Asn Pro Ile Ser Gln Pro Leu Leu 
    50                  55                  60                  


Asn Ile Gln Asn Tyr Pro Gln Gln Ile Ser Val Ser Asp Met His Asn 
65                  70                  75                  80  


Gly Thr Val Val Ala Ser His Thr Ser Val Glu Arg Ile Thr Tyr Ala 
                85                  90                  95      


Asn Val Asn Gly Pro Lys Gln Leu Thr His Asn Leu Gln Met Ser Ser 
            100                 105                 110         


Gly Val Thr Gln Asn Val Trp Leu Asn Ser Pro Met Arg Asn Pro Val 
        115                 120                 125             


His Ser His Ile Gly Ala Thr Val Ser His Gln Thr Asp Phe Gly Ala 
    130                 135                 140                 


Asn Val Pro Asn Met Pro Ala Leu Gln Ser Gln Leu Ile Thr Ser Asp 
145                 150                 155                 160 


Thr Tyr Ser Met Gln Met Gln Met Ile Pro Ser Asn Ser Thr Arg Leu 
                165                 170                 175     


Pro Val Ala Tyr Gln Gly Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu 
            180                 185                 190         


Gln Gln Val Asp Trp Thr Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr 
        195                 200                 205             


Pro Asp Tyr Arg Pro Pro Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser 
    210                 215                 220                 


Phe Leu Pro Asp Ser Thr Ile Gln Lys Gln Asn Phe Ile Pro His Thr 
225                 230                 235                 240 


Ser Leu Gln Val Lys Asn Ser Gln Leu Leu Asn Ser Val Leu Thr Leu 
                245                 250                 255     


Pro Ser Arg Gln Thr Ser Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln 
            260                 265                 270         


Thr Asp Lys Arg Pro Pro Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser 
        275                 280                 285             


Gln Pro Leu Gln Ser Thr Gln His Ile Thr Lys His Leu Ser Met Glu 
    290                 295                 300                 


Val Pro Gln Ser Arg Glu Met Leu Ser Ser Glu Ile Arg Thr Ser Phe 
305                 310                 315                 320 


Gln Gln Gln Trp Gln Asn Pro Asn Glu Asn Val Ser Thr Ile Gly Asn 
                325                 330                 335     


Phe Thr Asn Leu Lys Val Asn Thr Asn Ser Lys Gln Pro Phe Asn Ser 
            340                 345                 350         


Pro Ile Arg Ser Ser Val Asp Gly Val Gln Thr Leu Ala Gln Thr Asn 
        355                 360                 365             


Glu Glu Lys Ile Met Asp Ser Cys Asn Pro Thr Ser Asn Gln Val Leu 
    370                 375                 380                 


Asp Thr Ser Val Ala Lys Glu Lys Leu Val Arg Asp Ile Lys Thr Leu 
385                 390                 395                 400 


Val Glu Ile Lys Gln Lys Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile 
                405                 410                 415     


Asn Lys Asp Leu Leu Met Ala Ala Gly Cys Ile Lys Met Thr Asn Thr 
            420                 425                 430         


Ser Tyr Ser Glu Pro Ala Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr 
        435                 440                 445             


Ala Lys Ile Gln Ser Gly Pro Gln Ile Thr Pro Val Met Pro Glu Asn 
    450                 455                 460                 


Ala Glu Arg Gln Thr Pro Thr Val Val Glu Ser Ala Glu Thr Asn Lys 
465                 470                 475                 480 


Thr Gln Cys Met Leu Asn Ser Asp Ile Gln Glu Val Asn Cys Arg Arg 
                485                 490                 495     


Phe Asn Gln Val Asp Ser Val Leu Pro Asn Pro Val Tyr Ser Glu Lys 
            500                 505                 510         


Arg Pro Met Pro Asp Ser Ser His Asp Val Lys Val Leu Thr Ser Lys 
        515                 520                 525             


Thr Ser Ala Val Glu Met Thr Gln Ala Val Leu Asn Thr Gln Leu Ser 
    530                 535                 540                 


Ser Glu Asn Val Thr Lys Val Glu Gln Asn Ser Pro Ala Val Cys Glu 
545                 550                 555                 560 


Thr Ile Ser Val Pro Lys Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys 
                565                 570                 575     


Ile Gln Asn Glu Asn Met Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg 
            580                 585                 590         


Lys Thr Gln Lys Thr Val Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp 
        595                 600                 605             


Ser Lys Pro Asp Ser Cys Glu Met Asn Pro Asn Thr Gln Met Thr Gly 
    610                 615                 620                 


Asn Gln Leu Asn Leu Lys Asn Met Glu Thr Pro Ser Thr Ser Asn Val 
625                 630                 635                 640 


Ser Gly Arg Val Leu Asp Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser 
                645                 650                 655     


Thr Lys Gly Met Pro Ala Lys Ser Asp Ser Ser Cys Ser Met Glu Val 
            660                 665                 670         


Leu Ala Thr Cys Leu Ser Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala 
        675                 680                 685             


Lys Glu Lys Glu Cys Asp Lys Leu Arg Thr Asn Thr Thr Ala Val Gly 
    690                 695                 700                 


Ile Ser Lys Pro Ala Asn Ile His Val Lys Ser Pro Cys Ser Val Val 
705                 710                 715                 720 


Gly Asn Ser Asn Ser Gln Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr 
                725                 730                 735     


Ala Leu Ser Met Val Met His Asn Tyr Glu Ser Ser Gly Ile Asn Ile 
            740                 745                 750         


Thr Lys Gly Thr Glu Leu Gln Ile Ala Val Val Ser Pro Leu Val Leu 
        755                 760                 765             


Ser Glu Val Lys Thr Leu Ser Val Lys Gly Ile Thr Pro Ala Val Leu 
    770                 775                 780                 


Pro Glu Thr Val Tyr Pro Val Ile Lys Glu Gly Ser Val Cys Ser Leu 
785                 790                 795                 800 


Gln Asn Gln Leu Ala Glu Asn Ala Lys Ala Thr Ala Ala Leu Lys Val 
                805                 810                 815     


Asp Val Ser Gly Pro Val Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe 
            820                 825                 830         


Pro Leu Thr Gln Lys Glu Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser 
        835                 840                 845             


Glu Val Thr Pro Asn Val Asn Gln Gly Lys His Asn Lys Leu Glu Ser 
    850                 855                 860                 


Ala Ile His Ser Pro Met Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg 
865                 870                 875                 880 


Asn Ser Thr Val Val Ser Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys 
                885                 890                 895     


Ser Leu Val Glu Gly Asp Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile 
            900                 905                 910         


Phe Ser Ser Leu Pro Leu Lys Met Val Glu Pro Gln Lys Pro Ser Leu 
        915                 920                 925             


Pro Asn Gln Gln Gly Ile Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp 
    930                 935                 940                 


Asn Thr Thr Glu Asn Lys Asp Phe Gly Phe Gln Lys Asp Lys Pro Val 
945                 950                 955                 960 


Gln Cys Thr Asp Val Ser His Lys Ile Cys Asp Gln Ser Lys Ser Glu 
                965                 970                 975     


Pro Pro Leu Glu Ser Ser Phe Asn Asn Leu Glu Thr Asn Arg Val Ile 
            980                 985                 990         


Leu Glu Lys Ser Ser Leu Glu His  Ala Thr Glu Lys Ser  Thr Ala Asn 
        995                 1000                 1005             


Asp Thr  Cys Ser Ser Ala Ala  Ile Gln Glu Asp Ile  Tyr Pro Gln 
    1010                 1015                 1020             


Glu Ile  Asp Ala Ser Ser Asn  Tyr Thr Pro Gln Asp  Pro Ala Arg 
    1025                 1030                 1035             


Asn Glu  Ile His Ser Asp Lys  Ala Pro Val Leu Tyr  Leu His Asp 
    1040                 1045                 1050             


Gln Leu  Ser Glu Leu Leu Lys  Glu Phe Pro Tyr Gly  Ile Glu Ala 
    1055                 1060                 1065             


Val Asn  Thr Arg Glu Gly Ser  Val Gly Gln Gln Thr  Thr Tyr Gln 
    1070                 1075                 1080             


Thr Ser  Glu Asp Gln Thr Ala  Asp Lys Thr Ser Ser  Asp Ser Lys 
    1085                 1090                 1095             


Asp Pro  Ala Asp Gln Ile Gln  Ile Thr Ile Leu Ser  Ser Glu Gln 
    1100                 1105                 1110             


Met Lys  Glu Ile Phe Pro Glu  Gln Asp Asp Gln Pro  Tyr Val Val 
    1115                 1120                 1125             


Asp Lys  Leu Ala Glu Pro Gln  Lys Glu Glu Pro Ile  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Gln Cys Asp Leu Gln  Ala Pro Ala Ala Gly  Gln Ser Arg 
    1145                 1150                 1155             


Asp Ser  Val Ile Leu Asp Ser  Glu Lys Asp Asp Ile  His Cys Cys 
    1160                 1165                 1170             


Ala Leu  Gly Trp Leu Ser Met  Val Tyr Glu Gly Val  Pro Gln Cys 
    1175                 1180                 1185             


Gln Cys  Asn Ser Ile Lys Asn  Ser Ser Ser Glu Glu  Glu Lys Gln 
    1190                 1195                 1200             


Lys Glu  Gln Cys Ser Pro Leu  Asp Thr Asn Ser Cys  Lys Gln Gly 
    1205                 1210                 1215             


Glu Arg  Thr Ser Asp Arg Asp  Val Thr Val Val Gln  Phe Lys Ser 
    1220                 1225                 1230             


Leu Val  Asn Asn Pro Lys Thr  Pro Pro Asp Gly Lys  Ser His Phe 
    1235                 1240                 1245             


Pro Glu  Leu Gln Asp Asp Ser  Arg Lys Asp Thr Pro  Lys Thr Lys 
    1250                 1255                 1260             


His Lys  Ser Leu Pro Arg Thr  Glu Gln Glu Leu Val  Ala Gly Gln 
    1265                 1270                 1275             


Phe Ser  Ser Lys Cys Asp Lys  Leu Asn Pro Leu Gln  Asn His Lys 
    1280                 1285                 1290             


Arg Lys  Lys Leu Arg Phe His  Glu Val Thr Phe His  Ser Ser Asn 
    1295                 1300                 1305             


Lys Met  Thr Ala Ser Tyr Glu  Gln Ala Ser Gln Glu  Thr Arg Gln 
    1310                 1315                 1320             


Lys Lys  His Val Thr Gln Asn  Ser Arg Pro Leu Lys  Thr Lys Thr 
    1325                 1330                 1335             


Ala Phe  Leu Pro Asn Lys Asp  Val Tyr Lys Lys His  Ser Ser Leu 
    1340                 1345                 1350             


Gly Gln  Ser Leu Ser Pro Glu  Lys Ile Lys Leu Lys  Leu Lys Ser 
    1355                 1360                 1365             


Val Ser  Phe Lys Gln Lys Arg  Lys Leu Asp Gln Gly  Asn Val Leu 
    1370                 1375                 1380             


Asp Met  Glu Val Lys Lys Lys  Lys His Asp Lys Gln  Glu Gln Lys 
    1385                 1390                 1395             


Gly Ser  Val Gly Ala Thr Phe  Lys Leu Gly Asp Ser  Leu Ser Asn 
    1400                 1405                 1410             


Pro Asn  Glu Arg Ala Ile Val  Lys Glu Lys Met Val  Ser Asn Thr 
    1415                 1420                 1425             


Lys Ser  Val Asp Thr Lys Ala  Ser Ser Ser Lys Phe  Ser Arg Ile 
    1430                 1435                 1440             


Leu Thr  Pro Lys Glu Tyr Leu  Gln Arg Gln Lys His  Lys Glu Ala 
    1445                 1450                 1455             


Leu Ser  Asn Lys Ala Ser Lys  Lys Ile Cys Val Lys  Asn Val Pro 
    1460                 1465                 1470             


Cys Asp  Ser Glu His Met Arg  Pro Ser Lys Leu Ala  Val Gln Val 
    1475                 1480                 1485             


Glu Ser  Cys Gly Lys Ser Asn  Glu Lys His Ser Ser  Gly Val Gln 
    1490                 1495                 1500             


Thr Ser  Lys Glu Ser Leu Asn  Gly Leu Thr Ser His  Gly Lys Asn 
    1505                 1510                 1515             


Leu Lys  Ile His His Ser Gln  Glu Ser Lys Thr Tyr  Asn Ile Leu 
    1520                 1525                 1530             


Arg Asn  Val Lys Glu Lys Val  Gly Gly Lys Gln Pro  Asp Lys Ile 
    1535                 1540                 1545             


Trp Ile  Asp Lys Thr Lys Leu  Asp Lys Leu Thr Asn  Ile Ser Asn 
    1550                 1555                 1560             


Glu Ala  Gln Phe Ser Gln Met  Pro Pro Gln Val Lys  Asp Gln Lys 
    1565                 1570                 1575             


Lys Leu  Tyr Leu Asn Arg Val  Gly Phe Lys Cys Thr  Glu Arg Glu 
    1580                 1585                 1590             


Ser Ile  Ser Leu Thr Lys Leu  Glu Ser Ser Pro Arg  Lys Leu His 
    1595                 1600                 1605             


Lys Asp  Lys Arg Gln Glu Asn  Lys His Lys Thr Phe  Leu Pro Val 
    1610                 1615                 1620             


Lys Gly  Asn Thr Glu Lys Ser  Asn Met Leu Glu Phe  Lys Leu Cys 
    1625                 1630                 1635             


Pro Asp  Ile Leu Leu Lys Asn  Thr Asn Ser Val Glu  Glu Arg Lys 
    1640                 1645                 1650             


Asp Val  Lys Pro His Pro Arg  Lys Glu Gln Ala Pro  Leu Gln Val 
    1655                 1660                 1665             


Ser Gly  Ile Lys Ser Thr Lys  Glu Asp Trp Leu Lys  Phe Val Ala 
    1670                 1675                 1680             


Thr Lys  Lys Arg Thr Gln Lys  Asp Ser Gln Glu Arg  Asp Asn Val 
    1685                 1690                 1695             


Asn Ser  Arg Leu Ser Lys Arg  Ser Phe Ser Ala Asp  Gly Phe Glu 
    1700                 1705                 1710             


Met Leu  Gln Asn Pro Val Lys  Asp Ser Lys Glu Met  Phe Gln Thr 
    1715                 1720                 1725             


Tyr Lys  Gln Met Tyr Leu Glu  Lys Arg Ser Arg Ser  Leu Gly Ser 
    1730                 1735                 1740             


Ser Pro  Val Lys 
    1745         


<210>  5861
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1598__Homo_sapiens__NP_001120683

<400>  5861

Met Asn Ser Ser Asp Glu Glu Lys Gln Leu Gln Leu Ile Thr Ser Leu 
1               5                   10                  15      


Lys Glu Gln Ala Ile Gly Glu Tyr Glu Asp Leu Arg Ala Glu Asn Gln 
            20                  25                  30          


Lys Thr Lys Glu Lys Cys Asp Lys Ile Arg Gln Glu Arg Asp Glu Ala 
        35                  40                  45              


Val Lys Lys Leu Glu Glu Phe Gln Lys Ile Ser His Met Val Ile Glu 
    50                  55                  60                  


Glu Val Asn Phe Met Gln Asn His Leu Glu Ile Glu Lys Thr Cys Arg 
65                  70                  75                  80  


Glu Ser Ala Glu Ala Leu Ala Thr Lys Leu Asn Lys Glu Asn Lys Thr 
                85                  90                  95      


Leu Lys Arg Ile Ser Met Leu Tyr Met Ala Lys Leu Gly Pro Asp Val 
            100                 105                 110         


Ile Thr Glu Glu Ile Asn Ile Asp Asp Glu Asp Ser Thr Thr Asp Thr 
        115                 120                 125             


Asp Gly Ala Ala Glu Thr Cys Val Ser Val Gln Cys Gln Lys Gln Ile 
    130                 135                 140                 


Lys Glu Leu Arg Asp Gln Ile Val Ser Val Gln Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Leu Ala Ile Glu Leu Glu Asn Leu Lys Ser Lys Leu Val Glu Val Ile 
                165                 170                 175     


Glu Glu Val Asn Lys Val Lys Gln Glu Lys Thr Val Leu Asn Ser Glu 
            180                 185                 190         


Val Leu Glu Gln Arg Lys Val Leu Glu Lys Cys Asn Arg Val Ser Met 
        195                 200                 205             


Leu Ala Val Glu Glu Tyr Glu Glu Met Gln Val Asn Leu Glu Leu Glu 
    210                 215                 220                 


Lys Asp Leu Arg Lys Lys Ala Glu Ser Phe Ala Gln Glu Met Phe Ile 
225                 230                 235                 240 


Glu Gln Asn Lys Leu Lys Arg Gln Ser His Leu Leu Leu Gln Ser Ser 
                245                 250                 255     


Ile Pro Asp Gln Gln Leu Leu Lys Ala Leu Asp Glu Asn Ala Lys Leu 
            260                 265                 270         


Thr Gln Gln Leu Glu Glu Glu Arg Ile Gln His Gln Gln Lys Val Lys 
        275                 280                 285             


Glu Leu Glu Glu Gln Leu Glu Asn Glu Thr Leu His Lys Glu Ile His 
    290                 295                 300                 


Asn Leu Lys Gln Gln Leu Glu Leu Leu Glu Glu Asp Lys Lys Glu Leu 
305                 310                 315                 320 


Glu Leu Lys Tyr Gln Asn Ser Glu Glu Lys Ala Arg Asn Leu Lys His 
                325                 330                 335     


Ser Val Asp Glu Leu Gln Lys Arg Val Asn Gln Ser Glu Asn Ser Val 
            340                 345                 350         


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Asn 
        355                 360                 365             


Pro Ile Arg Ser Leu Met Ser Met Ile Arg Lys Arg Ser His Pro Ser 
    370                 375                 380                 


Gly Ser Gly Ala Lys Lys Glu Lys Ala Thr Gln Pro Glu Thr Thr Glu 
385                 390                 395                 400 


Glu Val Thr Asp Leu Lys Arg Gln Ala Val Glu Glu Met Met Asp Arg 
                405                 410                 415     


Ile Lys Lys Gly Val His Leu Arg Pro Val Asn Gln Thr Ala Arg Pro 
            420                 425                 430         


Lys Thr Lys Pro Glu Ser Ser Lys Gly Cys Glu Ser Ala Val Asp Glu 
        435                 440                 445             


Leu Lys Gly Ile Leu Gly Thr Leu Asn Lys Ser Thr Ser Ser Arg Ser 
    450                 455                 460                 


Leu Lys Ser Leu Asp Pro Glu Asn Ser Glu Thr Glu Leu Glu Arg Ile 
465                 470                 475                 480 


Leu Arg Arg Arg Lys Val Thr Ala Glu Ala Asp Ser Ser Ser Pro Thr 
                485                 490                 495     


Gly Ile Leu Ala Thr Ser Glu Ser Lys Ser Met Pro Val Leu Gly Ser 
            500                 505                 510         


Val Ser Ser Val Thr Lys Thr Ala Leu Asn Lys Lys Thr Leu Glu Ala 
        515                 520                 525             


Glu Phe Asn Ser Pro Ser Pro Pro Thr Pro Glu Pro Gly Glu Gly Pro 
    530                 535                 540                 


Arg Lys Leu Glu Gly Cys Thr Ser Ser Lys Val Thr Phe Gln Pro Pro 
545                 550                 555                 560 


Ser Ser Ile Gly Cys Arg Lys Lys Tyr Ile Asp Gly Glu Lys Gln Ala 
                565                 570                 575     


Glu Pro Val Val Val Leu Asp Pro Val Ser Thr His Glu Pro Gln Thr 
            580                 585                 590         


Lys Asp Gln Val Ala Glu Lys Asp Pro Thr Gln His Lys Glu Asp Glu 
        595                 600                 605             


Gly Glu Ile Gln Pro Glu Asn Lys Glu Asp Ser Ile Glu Asn Val Arg 
    610                 615                 620                 


Glu Thr Asp Ser Ser Asn Cys 
625                 630     


<210>  5862
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1715__Homo_sapiens__NP_001291937

<400>  5862

Met Gly Arg Ser Trp Pro Gly Leu Ser Leu Cys Gln Trp Arg Leu Leu 
1               5                   10                  15      


Pro Ala Leu Glu Ala Gly Trp Ala Val Ala Ala Glu Thr Gly Gly Gly 
            20                  25                  30          


Gly Arg Pro Gly Arg Ala Ala Pro Ala Ser Cys Ser Cys Glu Phe Leu 
        35                  40                  45              


Trp Thr Ile Asp Asp Ile Tyr His Cys Ala Gln Phe Leu Gln Ile Lys 
    50                  55                  60                  


Asp Gly Trp Ile Ile Phe Ser Met Glu Gly Lys Thr Lys Pro Ser Thr 
65                  70                  75                  80  


Val Glu Val Leu Glu Ser Ile Asp Lys Glu Ile Gln Ala Leu Glu Glu 
                85                  90                  95      


Phe Arg Glu Lys Asn Gln Arg Leu Gln Lys Leu Trp Val Gly Arg Leu 
            100                 105                 110         


Ile Leu Tyr Ser Ser Val Leu Tyr Leu Phe Thr Cys Leu Ile Val Tyr 
        115                 120                 125             


Leu Trp Tyr Leu Pro Asp Glu Phe Thr Ala Arg Leu Ala Met Thr Leu 
    130                 135                 140                 


Pro Phe Phe Ala Phe Pro Leu Ile Ile Trp Ser Ile Arg Thr Val Ile 
145                 150                 155                 160 


Ile Phe Phe Phe Ser Lys Arg Thr Glu Arg Asn Asn Glu Ala Leu Asp 
                165                 170                 175     


Asp Leu Lys Ser Gln Arg Lys Lys Ile Leu Glu Glu Val Met Glu Lys 
            180                 185                 190         


Glu Thr Tyr Lys Thr Ala Lys Leu Ile Leu Glu Arg Phe Asp Pro Asp 
        195                 200                 205             


Ser Lys Lys Ala Lys Glu Cys Glu Pro Pro Ser Ala Gly Ala Ala Val 
    210                 215                 220                 


Thr Ala Arg Pro Gly Gln Glu Ile Arg Gln Arg Thr Ala Ala Gln Arg 
225                 230                 235                 240 


Asn Leu Ser Pro Thr Pro Ala Ser Pro Asn Gln Gly Pro Pro Pro Gln 
                245                 250                 255     


Val Pro Val Ser Pro Gly Pro Pro Lys Asp Ser Ser Ala Pro Gly Gly 
            260                 265                 270         


Pro Pro Glu Arg Thr Val Thr Pro Ala Leu Ser Ser Asn Val Leu Pro 
        275                 280                 285             


Arg His Leu Gly Ser Pro Ala Thr Ser Val Pro Gly Met Gly Leu His 
    290                 295                 300                 


Pro Pro Gly Pro Pro Leu Ala Arg Pro Ile Leu Pro Arg Glu Arg Gly 
305                 310                 315                 320 


Ala Leu Asp Arg Ile Val Glu Tyr Leu Val Gly Asp Gly Pro Gln Asn 
                325                 330                 335     


Arg Tyr Ala Leu Ile Cys Gln Gln Cys Phe Ser His Asn Gly Met Ala 
            340                 345                 350         


Leu Lys Glu Glu Phe Glu Tyr Ile Ala Phe Arg Cys Ala Tyr Cys Phe 
        355                 360                 365             


Phe Leu Asn Pro Ala Arg Lys Thr Arg Pro Gln Ala Pro Arg Leu Pro 
    370                 375                 380                 


Glu Phe Ser Phe Glu Lys Arg Gln Val Val Glu Gly Ser Ser Ser Val 
385                 390                 395                 400 


Gly Pro Leu Pro Ser Gly Ser Val Leu Ser Ser Asp Asn Gln Phe Asn 
                405                 410                 415     


Glu Glu Ser Leu Glu His Asp Val Leu Asp Asp Asn Thr Glu Gln Thr 
            420                 425                 430         


Asp Asp Lys Ile Pro Ala Thr Glu Gln Thr Asn Gln Val Ile Glu Lys 
        435                 440                 445             


Ala Ser Asp Ser Glu Glu Pro Glu Glu Lys Gln Glu Thr Glu Asn Glu 
    450                 455                 460                 


Glu Ala Ser Val Ile Glu Thr Asn Ser Thr Val Pro Gly Ala Asp Ser 
465                 470                 475                 480 


Ile Pro Asp Pro Glu Leu Ser Gly Glu Ser Leu Thr Ala Glu 
                485                 490                 


<210>  5863
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1804__Homo_sapiens__NP_115811

<400>  5863

Met Ala Leu Arg Gly Ala Ala Gly Ala Thr Asp Thr Pro Val Ser Ser 
1               5                   10                  15      


Ala Gly Gly Ala Pro Gly Gly Ser Ala Ser Ser Ser Ser Thr Ser Ser 
            20                  25                  30          


Gly Gly Ser Ala Ser Ala Gly Ala Gly Leu Trp Ala Ala Leu Tyr Asp 
        35                  40                  45              


Tyr Glu Ala Arg Gly Glu Asp Glu Leu Ser Leu Arg Arg Gly Gln Leu 
    50                  55                  60                  


Val Glu Val Leu Ser Gln Asp Ala Ala Val Ser Gly Asp Glu Gly Trp 
65                  70                  75                  80  


Trp Ala Gly Gln Val Gln Arg Arg Leu Gly Ile Phe Pro Ala Asn Tyr 
                85                  90                  95      


Val Ala Pro Cys Arg Pro Ala Ala Ser Pro Ala Pro Pro Pro Ser Arg 
            100                 105                 110         


Pro Ser Ser Pro Val His Val Ala Phe Glu Arg Leu Glu Leu Lys Glu 
        115                 120                 125             


Leu Ile Gly Ala Gly Gly Phe Gly Gln Val Tyr Arg Ala Thr Trp Gln 
    130                 135                 140                 


Gly Gln Glu Val Ala Val Lys Ala Ala Arg Gln Asp Pro Glu Gln Asp 
145                 150                 155                 160 


Ala Ala Ala Ala Ala Glu Ser Val Arg Arg Glu Ala Arg Leu Phe Ala 
                165                 170                 175     


Met Leu Arg His Pro Asn Ile Ile Glu Leu Arg Gly Val Cys Leu Gln 
            180                 185                 190         


Gln Pro His Leu Cys Leu Val Leu Glu Phe Ala Arg Gly Gly Ala Leu 
        195                 200                 205             


Asn Arg Ala Leu Ala Ala Ala Asn Ala Ala Pro Asp Pro Arg Ala Pro 
    210                 215                 220                 


Gly Pro Arg Arg Ala Arg Arg Ile Pro Pro His Val Leu Val Asn Trp 
225                 230                 235                 240 


Ala Val Gln Ile Ala Arg Gly Met Leu Tyr Leu His Glu Glu Ala Phe 
                245                 250                 255     


Val Pro Ile Leu His Arg Asp Leu Lys Ser Ser Asn Ile Leu Leu Leu 
            260                 265                 270         


Glu Lys Ile Glu His Asp Asp Ile Cys Asn Lys Thr Leu Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr Thr Lys Met Ser Thr 
    290                 295                 300                 


Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Lys Ser Ser Leu 
305                 310                 315                 320 


Phe Ser Lys Gly Ser Asp Ile Trp Ser Tyr Gly Val Leu Leu Trp Glu 
                325                 330                 335     


Leu Leu Thr Gly Glu Val Pro Tyr Arg Gly Ile Asp Gly Leu Ala Val 
            340                 345                 350         


Ala Tyr Gly Val Ala Val Asn Lys Leu Thr Leu Pro Ile Pro Ser Thr 
        355                 360                 365             


Cys Pro Glu Pro Phe Ala Lys Leu Met Lys Glu Cys Trp Gln Gln Asp 
    370                 375                 380                 


Pro His Ile Arg Pro Ser Phe Ala Leu Ile Leu Glu Gln Leu Thr Ala 
385                 390                 395                 400 


Ile Glu Gly Ala Val Met Thr Glu Met Pro Gln Glu Ser Phe His Ser 
                405                 410                 415     


Met Gln Asp Asp Trp Lys Leu Glu Ile Gln Gln Met Phe Asp Glu Leu 
            420                 425                 430         


Arg Thr Lys Glu Lys Glu Leu Arg Ser Arg Glu Glu Glu Leu Thr Arg 
        435                 440                 445             


Ala Ala Leu Gln Gln Lys Ser Gln Glu Glu Leu Leu Lys Arg Arg Glu 
    450                 455                 460                 


Gln Gln Leu Ala Glu Arg Glu Ile Asp Val Leu Glu Arg Glu Leu Asn 
465                 470                 475                 480 


Ile Leu Ile Phe Gln Leu Asn Gln Glu Lys Pro Lys Val Lys Lys Arg 
                485                 490                 495     


Lys Gly Lys Phe Lys Arg Ser Arg Leu Lys Leu Lys Asp Gly His Arg 
            500                 505                 510         


Ile Ser Leu Pro Ser Asp Phe Gln His Lys Ile Thr Val Gln Ala Ser 
        515                 520                 525             


Pro Asn Leu Asp Lys Arg Arg Ser Leu Asn Ser Ser Ser Ser Ser Pro 
    530                 535                 540                 


Pro Ser Ser Pro Thr Met Met Pro Arg Leu Arg Ala Ile Gln Leu Thr 
545                 550                 555                 560 


Ser Asp Glu Ser Asn Lys Thr Trp Gly Arg Asn Thr Val Phe Arg Gln 
                565                 570                 575     


Glu Glu Phe Glu Asp Val Lys Arg Asn Phe Lys Lys Lys Gly Cys Thr 
            580                 585                 590         


Trp Gly Pro Asn Ser Ile Gln Met Lys Asp Arg Thr Asp Cys Lys Glu 
        595                 600                 605             


Arg Ile Arg Pro Leu Ser Asp Gly Asn Ser Pro Trp Ser Thr Ile Leu 
    610                 615                 620                 


Ile Lys Asn Gln Lys Thr Met Pro Leu Ala Ser Leu Phe Val Asp Gln 
625                 630                 635                 640 


Pro Gly Ser Cys Glu Glu Pro Lys Leu Ser Pro Asp Gly Leu Glu His 
                645                 650                 655     


Arg Lys Pro Lys Gln Ile Lys Leu Pro Ser Gln Ala Tyr Ile Asp Leu 
            660                 665                 670         


Pro Leu Gly Lys Asp Ala Gln Arg Glu Asn Pro Ala Glu Ala Glu Ser 
        675                 680                 685             


Trp Glu Glu Ala Ala Ser Ala Asn Ala Ala Thr Val Ser Ile Glu Met 
    690                 695                 700                 


Thr Pro Thr Asn Ser Leu Ser Arg Ser Pro Gln Arg Lys Lys Thr Glu 
705                 710                 715                 720 


Ser Ala Leu Tyr Gly Cys Thr Val Leu Leu Ala Ser Val Ala Leu Gly 
                725                 730                 735     


Leu Asp Leu Arg Glu Leu His Lys Ala Gln Ala Ala Glu Glu Pro Leu 
            740                 745                 750         


Pro Lys Glu Glu Lys Lys Lys Arg Glu Gly Ile Phe Gln Arg Ala Ser 
        755                 760                 765             


Lys Ser Arg Arg Ser Ala Ser Pro Pro Thr Ser Leu Pro Ser Thr Cys 
    770                 775                 780                 


Gly Glu Ala Ser Ser Pro Pro Ser Leu Pro Leu Ser Ser Ala Leu Gly 
785                 790                 795                 800 


Ile Leu Ser Thr Pro Ser Phe Ser Thr Lys Cys Leu Leu Gln Met Asp 
                805                 810                 815     


Ser Glu Asp Pro Leu Val Asp Ser Ala Pro Val Thr Cys Asp Ser Glu 
            820                 825                 830         


Met Leu Thr Pro Asp Phe Cys Pro Thr Ala Pro Gly Ser Gly Arg Glu 
        835                 840                 845             


Pro Ala Leu Met Pro Arg Leu Asp Thr Asp Cys Ser Val Ser Arg Asn 
    850                 855                 860                 


Leu Pro Ser Ser Phe Leu Gln Gln Thr Cys Gly Asn Val Pro Tyr Cys 
865                 870                 875                 880 


Ala Ser Ser Lys His Arg Pro Ser His His Arg Arg Thr Met Ser Asp 
                885                 890                 895     


Gly Asn Pro Thr Pro Thr Gly Ala Thr Ile Ile Ser Ala Thr Gly Ala 
            900                 905                 910         


Ser Ala Leu Pro Leu Cys Pro Ser Pro Ala Pro His Ser His Leu Pro 
        915                 920                 925             


Arg Glu Val Ser Pro Lys Lys His Ser Thr Val His Ile Val Pro Gln 
    930                 935                 940                 


Arg Arg Pro Ala Ser Leu Arg Ser Arg Ser Asp Leu Pro Gln Ala Tyr 
945                 950                 955                 960 


Pro Gln Thr Ala Val Ser Gln Leu Ala Gln Thr Ala Cys Val Val Gly 
                965                 970                 975     


Arg Pro Gly Pro His Pro Thr Gln Phe Leu Ala Ala Lys Glu Arg Thr 
            980                 985                 990         


Lys Ser His Val Pro Ser Leu Leu  Asp Ala Asp Val Glu  Gly Gln Ser 
        995                 1000                 1005             


Arg Asp  Tyr Thr Val Pro Leu  Cys Arg Met Arg Ser  Lys Thr Ser 
    1010                 1015                 1020             


Arg Pro  Ser Ile Tyr Glu Leu  Glu Lys Glu Phe Leu  Ser 
    1025                 1030                 1035     


<210>  5864
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1841__Homo_sapiens__XP_005264663

<400>  5864

Met Ser Arg Gly Tyr Ser Glu Asn Asn Asn Phe Leu Asn Asn Asn Asn 
1               5                   10                  15      


Gln Met Val Leu Asp Met Ile Leu Tyr Pro Leu Ile Gly Ile Pro Gln 
            20                  25                  30          


Thr Ile Asn Trp Glu Thr Ile Ala Arg Leu Val Pro Gly Leu Thr Pro 
        35                  40                  45              


Lys Glu Cys Ala Lys Arg Phe Asp Glu Leu Lys Ser Ser Gly Ser Ser 
    50                  55                  60                  


Pro Val Asp Asn Gln Tyr Asn Ser Leu Met Ala Ala Gly Glu Ser Pro 
65                  70                  75                  80  


Val Glu Thr Leu Ala Thr Tyr Ile Lys Ser Ser Leu Leu Asp Ile His 
                85                  90                  95      


Gly Glu Phe Gln Glu Thr Pro Val Gly His Asp Ala Val Ser Lys Thr 
            100                 105                 110         


Gly Arg His Ser Ile Ala Ser Thr Arg Asn Cys Ser Ser Glu Ser Glu 
        115                 120                 125             


Asn Cys Thr Thr His Asn Gly Gly Glu Met Thr Glu Glu Ser Glu Gly 
    130                 135                 140                 


Pro Asn Met Val Ile His Val Cys Asp Glu Ala Lys Asn Leu Lys Glu 
145                 150                 155                 160 


Asp Phe Thr Cys Pro Arg Asp Leu Leu Ile Ser Glu Met Lys Tyr Phe 
                165                 170                 175     


Ala Glu Tyr Leu Ser Met Asp Ala Gln Arg Trp Glu Glu Val Asp Ile 
            180                 185                 190         


Ser Val His Cys Asp Val His Ile Phe Asn Trp Leu Ile Lys Tyr Ile 
        195                 200                 205             


Lys Arg Asn Thr Lys Glu Asn Lys Asp Cys Glu Met Pro Thr Leu Glu 
    210                 215                 220                 


Pro Gly Asn Val Ile Ser Ile Leu Ile Ser Ser Glu Phe Leu Lys Met 
225                 230                 235                 240 


Asp Ser Leu Val Glu Gln Cys Ile Gln Tyr Cys His Lys Asn Met Asn 
                245                 250                 255     


Ala Ile Val Ala Thr Pro Cys Asn Met Asn Cys Ile Asn Ala Asn Leu 
            260                 265                 270         


Leu Thr Arg Ile Ala Asp Leu Phe Ser His Asn Glu Val Asp Asp Leu 
        275                 280                 285             


Lys Asp Lys Lys Asp Lys Phe Lys Ser Lys Leu Phe Cys Lys Lys Ile 
    290                 295                 300                 


Glu Arg Leu Phe Asp Pro Glu Tyr Leu Asn Pro Asp Ser Arg Ser Asn 
305                 310                 315                 320 


Ala Ala Thr Leu Tyr Arg Cys Cys Leu Cys Lys Lys Leu Leu Thr Lys 
                325                 330                 335     


Glu Thr Glu Arg Arg Ile Pro Cys Ile Pro Gly Lys Ile Asn Val Asp 
            340                 345                 350         


Arg Arg Gly Asn Ile Val Tyr Ile His Ile Arg Asp Lys Thr Trp Asp 
        355                 360                 365             


Val His Glu Tyr Leu Asn Ser Leu Phe Glu Glu Leu Lys Ser Trp Arg 
    370                 375                 380                 


Asp Val Tyr Trp Arg Leu Trp Gly Thr Ile Asn Trp Leu Thr Cys Ser 
385                 390                 395                 400 


Arg Cys Tyr Gln Ala Phe Leu Cys Ile Glu Phe Ser His Cys Gln Tyr 
                405                 410                 415     


His Ser Glu Thr Val Val Tyr Pro Thr Ala Ala Ser Ser Leu Asn Thr 
            420                 425                 430         


Val Gly Thr Gly Ile Tyr Pro Cys Cys Asn Gln Lys Val Leu Arg Phe 
        435                 440                 445             


Asp Pro Thr Gln Leu Thr Lys Gly Cys Lys Val Arg Asp His Met Val 
    450                 455                 460                 


Thr Leu Arg Asp Gln Gly Glu Gly Gly Asp Leu Pro Ser Cys Pro Thr 
465                 470                 475                 480 


Ala Arg Met Leu Asp Asp Leu His Lys Tyr Arg Asp Val Ile Val Val 
                485                 490                 495     


Pro Phe Ser Lys Asp Thr Val Ser Asp Val Gly Val Gly Leu Cys Asp 
            500                 505                 510         


Glu Lys Gly Ile Glu Cys Asp Val Leu Leu Glu Pro Asn Thr Pro Trp 
        515                 520                 525             


Gly Pro Lys Thr Gly Glu Leu Asn Ala Phe Leu Ser Leu Lys Asn Trp 
    530                 535                 540                 


Thr Leu Gln Leu Lys Gln Gln Ser Leu Phe Ser Glu Glu Glu Glu Tyr 
545                 550                 555                 560 


Thr Thr Gly Ser Glu Val Thr Glu Asp Glu Val Gly Asp Glu Glu Glu 
                565                 570                 575     


Val Ser Lys Lys Gln Arg Lys Lys Glu Lys Pro Lys Lys Phe Thr Arg 
            580                 585                 590         


Gln Pro Lys Lys Gln Val Ser Ser Pro Cys Ala Gln Arg Lys Glu Lys 
        595                 600                 605             


Ala Leu Glu Lys Ser Ala Ser Arg Asp Val Ser Pro Phe Val Met Ser 
    610                 615                 620                 


Met Gln Lys Asn Lys Trp Asp Ala Thr Arg Ser Leu Arg Phe Asn Gln 
625                 630                 635                 640 


Asp Ala Gln Arg Glu Asp Asp Gln Arg Arg Met Thr Glu Ile Thr Gly 
                645                 650                 655     


His Leu Ile Lys Met Arg Leu Gly Asp Leu Asp Arg Val Lys Ser Lys 
            660                 665                 670         


Glu Ala Lys Glu Thr Asp Lys Leu Arg Pro Arg Asp Gly Thr Val Ser 
        675                 680                 685             


Lys Ser Asn Arg Lys Ser Gly Leu Ser Ser Val Leu Leu Met Thr Val 
    690                 695                 700                 


Leu Leu Cys 
705         


<210>  5865
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1919__Homo_sapiens__NP_699200

<400>  5865

Met Leu Cys Ala Ser Phe Leu Gly Leu Gly Leu Ser Val Ala Ile Val 
1               5                   10                  15      


Gly Pro Thr Phe Gln Asp Leu Ala Thr Asn Val Asn Arg Asn Ile Ser 
            20                  25                  30          


Ser Leu Ser Phe Ile Phe Val Gly Arg Ala Leu Gly Tyr Leu Ser Gly 
        35                  40                  45              


Ser Val Ile Gly Gly Phe Leu Val Asp Val Met Asn Tyr Phe Leu Leu 
    50                  55                  60                  


Leu Gly Ile Ser Met Ser Ala Thr Thr Val Gly Leu Tyr Leu Val Pro 
65                  70                  75                  80  


Phe Cys Lys Thr Ala Ile Leu Leu Thr Val Met Met Ser Ile Phe Gly 
                85                  90                  95      


Val Ser Ile Gly Ile Leu Asp Thr Gly Gly Asn Val Leu Ile Leu Ala 
            100                 105                 110         


Ile Trp Gly Asp Lys Gly Ala Pro His Met Gln Ala Leu His Phe Ser 
        115                 120                 125             


Phe Ala Leu Gly Ala Phe Leu Ala Pro Leu Leu Ala Lys Leu Ala Leu 
    130                 135                 140                 


Gly Pro Thr Ala Ser Ala Glu Asn His Thr Glu Ser Asp Phe His Pro 
145                 150                 155                 160 


Ala Leu Asn Gln Ser Ser Asp Ala Asp Ser Glu Ala Leu Phe Gly Val 
                165                 170                 175     


Pro Asn Asp Lys Asn Leu Leu Trp Ala Tyr Ala Val Ile Gly Thr Tyr 
            180                 185                 190         


Met Phe Leu Val Ser Val Ile Phe Phe Cys Leu Phe Leu Lys Asn Ser 
        195                 200                 205             


Ser Lys Gln Glu Lys Ala Arg Ala Ser Ala Glu Thr Phe Arg Arg Ala 
    210                 215                 220                 


Lys Tyr His Asn Ala Leu Leu Cys Leu Leu Phe Leu Phe Phe Phe Phe 
225                 230                 235                 240 


Tyr Val Gly Ala Glu Val Thr Tyr Gly Ser Tyr Val Phe Ser Phe Ala 
                245                 250                 255     


Thr Thr His Ala Gly Met Lys Glu Ser Glu Ala Ala Gly Leu Asn Ser 
            260                 265                 270         


Ile Phe Trp Gly Thr Phe Ala Ala Cys Arg Gly Leu Ala Ile Phe Phe 
        275                 280                 285             


Ala Thr Cys Leu Gln Pro Gly Thr Met Ile Val Leu Ser Asn Ile Gly 
    290                 295                 300                 


Ser Leu Thr Ser Ser Leu Phe Leu Val Leu Phe Asp Lys Asn Pro Ile 
305                 310                 315                 320 


Cys Leu Trp Ile Ala Thr Ser Val Tyr Gly Ala Ser Met Ala Thr Thr 
                325                 330                 335     


Phe Pro Ser Gly Val Ser Trp Ile Glu Gln Tyr Thr Thr Ile His Gly 
            340                 345                 350         


Lys Ser Ala Ala Phe Phe Val Ile Gly Ala Ser Leu Gly Glu Met Ala 
        355                 360                 365             


Ile Pro Ala Val Ile Gly Ile Leu Gln Gly Lys Tyr Pro Asp Leu Pro 
    370                 375                 380                 


Val Val Leu Tyr Thr Ser Leu Gly Ala Ser Ile Ala Thr Gly Ile Leu 
385                 390                 395                 400 


Phe Pro Val Leu Tyr Lys Leu Ala Thr Ser Pro Leu Asp Arg Gln Arg 
                405                 410                 415     


Lys Glu Asp Arg Lys Ser Glu Asp Gln Lys Ala Leu Leu Ser Ser Ser 
            420                 425                 430         


Gly Leu Asn Glu Tyr Glu Glu Glu Asn Glu Glu Glu Asp Ala Glu Lys 
        435                 440                 445             


Trp Asn Glu Met Asp Phe Glu Met Ile Glu Thr Asn Asp Thr Met Arg 
    450                 455                 460                 


His Ser Ile Ile Glu Thr Ser Arg Ser Ser Leu Thr Glu Pro Thr Ala 
465                 470                 475                 480 


Glu Val Tyr Asn Gln Tyr Pro Ser Asn Ala Leu Val Phe Glu Ser Ser 
                485                 490                 495     


Pro Phe Asn Thr Gly Ser Ala His Val Lys His Leu Pro Glu Thr Arg 
            500                 505                 510         


Thr Lys Gly Thr Asn Val 
        515             


<210>  5866
<211>  1516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA2022__Homo_sapiens__NP_001008537

<400>  5866

Met Asp Asn Gln Gln Asp Lys Ala Ile Val Ala Ser Ala Asn Gly Glu 
1               5                   10                  15      


Asn Thr Leu Ile Asn Gly Val Lys Glu Asn Asp Ser Glu Asp Gln Asp 
            20                  25                  30          


Val Ala Met Lys Ser Phe Ala Ala Leu Glu Ala Ala Ala Pro Ile Gln 
        35                  40                  45              


Pro Thr Pro Val Ala Gln Lys Glu Thr Leu Met Tyr Pro Arg Gly Leu 
    50                  55                  60                  


Leu Pro Leu Pro Ser Lys Lys Pro Cys Met Gln Ser Pro Pro Ser Pro 
65                  70                  75                  80  


Leu Gly Leu Ile Glu Ala Pro Glu His Ala Ala Asn Ser Ala Ser Val 
                85                  90                  95      


Asn Ala Ile Ser Leu Thr Ser Gly Ile Ala Lys Gly Leu Asn Thr Trp 
            100                 105                 110         


Ser Leu Pro Asn Glu Cys Glu Lys Ala Pro Phe Ala Ile Met Glu Pro 
        115                 120                 125             


Ala Gly Met Ser Ala Leu Asn Gly Asp Cys Leu Met Gln Pro Ser Arg 
    130                 135                 140                 


Thr Cys Leu Gly Cys Phe Met Glu Ser Lys Asp Ala Val Asp Pro Glu 
145                 150                 155                 160 


Pro Gly Ile Ser Leu Lys Val Gly Asp Leu Asn Arg Asp Tyr Glu Thr 
                165                 170                 175     


Cys Ala Val Ser Asp Ile Gly Ile Gln Cys Ile Asn Ala Gly Glu Asn 
            180                 185                 190         


Met Lys Tyr Gly Glu Gln Leu Leu Ser Asp Gln Leu Leu Gly Phe Pro 
        195                 200                 205             


Leu His Lys Ser Arg Ala Gly Asp Arg Arg Glu Thr Glu Lys Pro Asp 
    210                 215                 220                 


Ile Asp Leu Glu Asp Pro Ala Gln Lys Ser Tyr Tyr Glu Ala Leu Leu 
225                 230                 235                 240 


Leu Asp Lys Cys Asn Thr Glu Glu Ala Leu Leu Ala Asn Ser Asn Gln 
                245                 250                 255     


Asp Trp Gly Tyr Phe Glu Thr Phe Ile Ser Glu Ser Lys Ile Glu Leu 
            260                 265                 270         


Leu Asp Leu Cys Ser Lys Asn Glu Leu Ser Val Asn Leu Phe Ser Glu 
        275                 280                 285             


Glu Asp Val Asp Asn Tyr Met Phe Asp Asp Asp Glu Ser Thr Leu Gly 
    290                 295                 300                 


Ser Asp Val Cys Ser Leu Lys Ile Arg Tyr Glu Ser Phe Gln Asp Asn 
305                 310                 315                 320 


Val Arg Asp Lys Thr Thr Leu Leu Met Gln Glu Asp Ala Gln Phe Asn 
                325                 330                 335     


Phe Phe Pro Ser Val Phe Thr Thr Cys Pro Lys Arg Glu Ser Lys Ser 
            340                 345                 350         


Gly Ala Leu Lys Gln Ser Ser Asp Phe Ser Gln Phe Lys Val Pro Asp 
        355                 360                 365             


Val Ser Ile Ile Trp Gly Glu Glu Asp Lys Asn Leu Asp Lys Lys Lys 
    370                 375                 380                 


Gly Lys Glu Glu Gly Gln Glu Asp Lys Gly Val Glu Lys Lys Asp Gly 
385                 390                 395                 400 


Lys Asp Asn Gly Glu Lys Pro Ala Leu Asn Lys Pro Cys Ser Gly Thr 
                405                 410                 415     


Glu Val Glu Gln Leu Lys Asn Pro Lys Gln Gly His Leu Ala Asn Ser 
            420                 425                 430         


Leu Glu Thr Ser Gly Ser Phe Ser Asp Asp Ser Ser Phe Ile Glu Ile 
        435                 440                 445             


Ser Tyr Asp Ala Met Gly Glu Ile Lys Asp Cys Ser Arg Tyr Met Ala 
    450                 455                 460                 


Arg Asp Thr Asn Ser Gly Ser Ser Ser Ser Gln Gln Asn Tyr Gly Leu 
465                 470                 475                 480 


Arg Ala Lys Arg Lys Val Arg Tyr Ser Glu Asp Tyr Leu Tyr Asp Val 
                485                 490                 495     


Asp Ser Leu Glu Gly Glu Lys Val Asn Glu Arg Lys Glu Trp Leu Pro 
            500                 505                 510         


Val Gly Ser Lys Glu Glu Asp Asp Asp Glu Trp Cys Pro Lys Lys Arg 
        515                 520                 525             


Arg Lys Val Thr Arg Lys Glu Pro Pro Val Ile Ile Lys Tyr Ile Ile 
    530                 535                 540                 


Ile Asn Arg Phe Lys Gly Glu Lys Asn Met Leu Val Lys Leu Gly Lys 
545                 550                 555                 560 


Val Asp Ala Ser Glu Thr Thr Val Asn Leu Ser Glu Asn Gln Leu Asn 
                565                 570                 575     


Lys Tyr Ala Lys Leu Ala Pro Leu Lys Gly Phe Trp Gln Lys Lys Lys 
            580                 585                 590         


Lys Gln Arg Asn Thr Asn Thr Asp Ser Ile Lys Thr Pro Phe Ser Gln 
        595                 600                 605             


Lys Gln Ser Phe Glu Pro Gly Ser Phe Glu Val Ser Phe Leu Pro Pro 
    610                 615                 620                 


Ala Arg Lys Arg Lys Ser Lys Leu Gly Asn Arg His Arg Ile Gln Arg 
625                 630                 635                 640 


Ile Pro Ser Ile Glu Ile Ser Ala Ser Ser Lys Gln Ile Ser Leu Cys 
                645                 650                 655     


Asn Asp Gln Arg His Ala Ser Asn His Lys Glu Asp Gly Gly Leu Lys 
            660                 665                 670         


Gly Thr Leu Lys Ser Ala Pro Leu Gly Ala Pro Ser Cys Ala Asn Gly 
        675                 680                 685             


Ser His Leu Asn Asp Ile Thr Gly Pro Asp Ser Val Lys Val Lys Ala 
    690                 695                 700                 


Gln Asp Thr Glu Phe Lys Gly Pro Glu Arg Lys Val Leu Asn Lys Ile 
705                 710                 715                 720 


Lys Phe Lys Ser Glu Ala Arg Leu Lys Ser Lys Lys Val Lys Ala Ala 
                725                 730                 735     


Gly Gln Glu Ser Lys Pro Ile Val Gln Met Ser Pro Leu Leu Glu Asn 
            740                 745                 750         


Gln Ser Ser Lys Ala Asn Leu Lys Asn Glu Val Ile Pro Gly Thr Ser 
        755                 760                 765             


Asn Ser Ser Arg Leu Ser Glu Phe His Glu Ala Lys Ala Ala Lys Ser 
    770                 775                 780                 


Ser Thr Phe Leu Pro Thr Thr Cys Ser Ser Glu Met Pro Leu Ser Ser 
785                 790                 795                 800 


Ala Asn Val Thr Thr Asn Ile Pro Val Ile Pro Gly Gly Tyr Leu Gln 
                805                 810                 815     


Thr Leu Leu Asp Ala Ser Asp Leu Ser Asn Asn Thr Ser Ile Ser Tyr 
            820                 825                 830         


Phe Ser His His Ser Pro Glu Gln Asn Glu Gly Ser Leu Thr Gln Thr 
        835                 840                 845             


Glu Lys Ser Phe Val Pro Leu Gln Pro Thr Gln Asp Cys Val Leu Thr 
    850                 855                 860                 


Ser Ser Ser Asp Ser Glu Leu Gln Gln Ser Ser His Asn Phe Lys Met 
865                 870                 875                 880 


Glu Ser Ser Asn Tyr Arg Asn Val Trp Pro Asn Lys Ala Thr Ser Gly 
                885                 890                 895     


Thr Gln Glu Phe Met Ala Glu Val Ser Arg Glu Ile Ala Pro Thr Gln 
            900                 905                 910         


Ser Ser Glu Phe Gly Ala Ser Gln Val Val Ser Met Glu Asn Asn Leu 
        915                 920                 925             


Thr Pro Thr Thr Tyr Asn Pro Ile Cys Leu Asn Ser Gly Gly Ser Asn 
    930                 935                 940                 


Cys Asn Lys Val Leu Tyr Asp Ser Met Gln Asp Thr Gln Leu Pro Ser 
945                 950                 955                 960 


Asp Asp Ser Tyr Gln Leu Cys His Phe Asn Asn Gly Glu Ile Cys Phe 
                965                 970                 975     


Pro Phe Gln Gln Gly Pro Val Asn Met Asp Asp Gly Arg Leu Phe Ser 
            980                 985                 990         


Phe Asp Ser Met Ala Pro Leu Ser  Val Ser Ser Ser Asn  Tyr Cys Ser 
        995                 1000                 1005             


Leu Ser  Leu Lys Ser Cys Glu  Lys Asp Gly Asp Asp  Asp Ile Thr 
    1010                 1015                 1020             


Asp Asp  Phe Leu Ala His Cys  Ser Pro Lys Leu Val  Ile Gln Gln 
    1025                 1030                 1035             


Ser Ile  Asp Glu Ile Ala Pro  Leu Lys Glu Ser Thr  Asp Leu Leu 
    1040                 1045                 1050             


Asp Ile  Ser Asn Phe Thr Pro  Asp Lys Phe Arg His  Ser Ser Leu 
    1055                 1060                 1065             


Ser Glu  Met Ser Pro Pro Asp  Thr Pro Ser Leu Ser  Pro Gln Ile 
    1070                 1075                 1080             


Thr Arg  Cys Glu Ser Met Lys  Thr Leu Gly Thr Leu  Lys Gly Phe 
    1085                 1090                 1095             


Gln Glu  Gly Val Pro Gly Pro  Leu Asp Ser Val Glu  Lys Ile Lys 
    1100                 1105                 1110             


Trp Asp  Cys Ser Thr Leu Ser  Arg Gln Val Gln Met  Glu Asp Gly 
    1115                 1120                 1125             


Phe Thr  Leu Asn Asn His Gln  Phe Gln Phe His Met  Phe Asn Asp 
    1130                 1135                 1140             


Glu Asp  Ser Val Ser Leu Leu  Gln Lys Asn Pro Cys  Leu Ser Thr 
    1145                 1150                 1155             


Phe Asn  Asp Pro Ser Gly Gln  Ile Ser Thr Asn Asn  Lys Val Ser 
    1160                 1165                 1170             


Lys Ser  Arg Lys Lys Ser Ser  Pro Ser Lys Ser Gly  Ala Met Asn 
    1175                 1180                 1185             


Gln Ser  Ser Ser Gln Lys Asn  Thr Arg Lys Lys Ser  Leu Lys Gly 
    1190                 1195                 1200             


Asn Asn  Lys Gly Ile Glu Lys  Pro Pro Gly Lys Asn  Ser Arg Gln 
    1205                 1210                 1215             


Val Pro  Lys Ser Thr Lys Lys  Gly Lys Tyr Met Ala  Ala Ile Asn 
    1220                 1225                 1230             


Gly Glu  Lys Met Gln Ile Gly  Ile Gly Arg Gly Gly  Ser Gln Thr 
    1235                 1240                 1245             


Asn Thr  Ile Ser Ser Thr Gly  Lys Thr Leu Ala Glu  Cys Ile Gln 
    1250                 1255                 1260             


His Gly  Gly Pro Met Ala Ser  Met Lys Met Pro Ser  Gln Lys Gly 
    1265                 1270                 1275             


Leu Ser  Gly Asp Trp Ala Leu  Gly Lys Glu Ser Ser  Pro Gly Trp 
    1280                 1285                 1290             


Ser Asp  Met Ser Met Gly Thr  Asn Thr Asn Ser Leu  Leu Asp Asp 
    1295                 1300                 1305             


Asp Gln  Arg Glu Phe Gln Glu  Pro Ser Tyr Ile Leu  Ser Asn Ile 
    1310                 1315                 1320             


Ala Ser  Gly Met Ala Asp Val  Gln Arg Phe Met Met  Ala Ser Ile 
    1325                 1330                 1335             


Glu Pro  Leu Trp Glu Pro Met  Glu His His Gly Asp  Pro Asn Ile 
    1340                 1345                 1350             


Phe Tyr  Ser Pro Glu Ser Asn  Ser Leu Lys Leu Lys  Thr Leu Lys 
    1355                 1360                 1365             


Ile Leu  Ala Gly Thr Pro Gln  Glu Ser Lys Lys Lys  Ile Asn Ser 
    1370                 1375                 1380             


Gly Ser  Gln Gly Ala Thr Lys  Asn His Arg Ser Ile  Lys Gly Val 
    1385                 1390                 1395             


Ser Lys  Ser Asn Gly Lys Thr  Ala Ile Gly Asp Pro  Gly Arg Ala 
    1400                 1405                 1410             


Asn Met  Pro Gly Tyr Asn Glu  Asp Ser Arg Ser Thr  Phe Phe Asp 
    1415                 1420                 1425             


Lys Lys  Tyr Ser Asn Met Ser  Thr Leu Gly Asn Asn  Gly Pro Thr 
    1430                 1435                 1440             


His Lys  Lys Leu Tyr Arg His  Lys Ser Ser Ser Lys  Ala Leu Arg 
    1445                 1450                 1455             


Asp Glu  Lys Cys Lys Gly Lys  His Met Glu Arg Glu  Gln Val His 
    1460                 1465                 1470             


Lys Asp  Glu Ser Gly Thr Ala  Ser Phe Glu Lys Leu  Arg Asp Ser 
    1475                 1480                 1485             


Asp Tyr  Asn Leu Leu Lys Ala  Glu Thr Thr Phe Trp  Val Leu Pro 
    1490                 1495                 1500             


Val Phe  Glu Glu Glu Thr Arg  Ile Phe Gln Lys Asp  Ile 
    1505                 1510                 1515     


<210>  5867
<211>  1771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIDINS220__Homo_sapiens__NP_065789

<400>  5867

Met Ser Val Leu Ile Ser Gln Ser Val Ile Asn Tyr Val Glu Glu Glu 
1               5                   10                  15      


Asn Ile Pro Ala Leu Lys Ala Leu Leu Glu Lys Cys Lys Asp Val Asp 
            20                  25                  30          


Glu Arg Asn Glu Cys Gly Gln Thr Pro Leu Met Ile Ala Ala Glu Gln 
        35                  40                  45              


Gly Asn Leu Glu Ile Val Lys Glu Leu Ile Lys Asn Gly Ala Asn Cys 
    50                  55                  60                  


Asn Leu Glu Asp Leu Asp Asn Trp Thr Ala Leu Ile Ser Ala Ser Lys 
65                  70                  75                  80  


Glu Gly His Val His Ile Val Glu Glu Leu Leu Lys Cys Gly Val Asn 
                85                  90                  95      


Leu Glu His Arg Asp Met Gly Gly Trp Thr Ala Leu Met Trp Ala Cys 
            100                 105                 110         


Tyr Lys Gly Arg Thr Asp Val Val Glu Leu Leu Leu Ser His Gly Ala 
        115                 120                 125             


Asn Pro Ser Val Thr Gly Leu Tyr Ser Val Tyr Pro Ile Ile Trp Ala 
    130                 135                 140                 


Ala Gly Arg Gly His Ala Asp Ile Val His Leu Leu Leu Gln Asn Gly 
145                 150                 155                 160 


Ala Lys Val Asn Cys Ser Asp Lys Tyr Gly Thr Thr Pro Leu Val Trp 
                165                 170                 175     


Ala Ala Arg Lys Gly His Leu Glu Cys Val Lys His Leu Leu Ala Met 
            180                 185                 190         


Gly Ala Asp Val Asp Gln Glu Gly Ala Asn Ser Met Thr Ala Leu Ile 
        195                 200                 205             


Val Ala Val Lys Gly Gly Tyr Thr Gln Ser Val Lys Glu Ile Leu Lys 
    210                 215                 220                 


Arg Asn Pro Asn Val Asn Leu Thr Asp Lys Asp Gly Asn Thr Ala Leu 
225                 230                 235                 240 


Met Ile Ala Ser Lys Glu Gly His Thr Glu Ile Val Gln Asp Leu Leu 
                245                 250                 255     


Asp Ala Gly Thr Tyr Val Asn Ile Pro Asp Arg Ser Gly Asp Thr Val 
            260                 265                 270         


Leu Ile Gly Ala Val Arg Gly Gly His Val Glu Ile Val Arg Ala Leu 
        275                 280                 285             


Leu Gln Lys Tyr Ala Asp Ile Asp Ile Arg Gly Gln Asp Asn Lys Thr 
    290                 295                 300                 


Ala Leu Tyr Trp Ala Val Glu Lys Gly Asn Ala Thr Met Val Arg Asp 
305                 310                 315                 320 


Ile Leu Gln Cys Asn Pro Asp Thr Glu Ile Cys Thr Lys Asp Gly Glu 
                325                 330                 335     


Thr Pro Leu Ile Lys Ala Thr Lys Met Arg Asn Ile Glu Val Val Glu 
            340                 345                 350         


Leu Leu Leu Asp Lys Gly Ala Lys Val Ser Ala Val Asp Lys Lys Gly 
        355                 360                 365             


Asp Thr Pro Leu His Ile Ala Ile Arg Gly Arg Ser Arg Lys Leu Ala 
    370                 375                 380                 


Glu Leu Leu Leu Arg Asn Pro Lys Asp Gly Arg Leu Leu Tyr Arg Pro 
385                 390                 395                 400 


Asn Lys Ala Gly Glu Thr Pro Tyr Asn Ile Asp Cys Ser His Gln Lys 
                405                 410                 415     


Ser Ile Leu Thr Gln Ile Phe Gly Ala Arg His Leu Ser Pro Thr Glu 
            420                 425                 430         


Thr Asp Gly Asp Met Leu Gly Tyr Asp Leu Tyr Ser Ser Ala Leu Ala 
        435                 440                 445             


Asp Ile Leu Ser Glu Pro Thr Met Gln Pro Pro Ile Cys Val Gly Leu 
    450                 455                 460                 


Tyr Ala Gln Trp Gly Ser Gly Lys Ser Phe Leu Leu Lys Lys Leu Glu 
465                 470                 475                 480 


Asp Glu Met Lys Thr Phe Ala Gly Gln Gln Ile Glu Pro Leu Phe Gln 
                485                 490                 495     


Phe Ser Trp Leu Ile Val Phe Leu Thr Leu Leu Leu Cys Gly Gly Leu 
            500                 505                 510         


Gly Leu Leu Phe Ala Phe Thr Val His Pro Asn Leu Gly Ile Ala Val 
        515                 520                 525             


Ser Leu Ser Phe Leu Ala Leu Leu Tyr Ile Phe Phe Ile Val Ile Tyr 
    530                 535                 540                 


Phe Gly Gly Arg Arg Glu Gly Glu Ser Trp Asn Trp Ala Trp Val Leu 
545                 550                 555                 560 


Ser Thr Arg Leu Ala Arg His Ile Gly Tyr Leu Glu Leu Leu Leu Lys 
                565                 570                 575     


Leu Met Phe Val Asn Pro Pro Glu Leu Pro Glu Gln Thr Thr Lys Ala 
            580                 585                 590         


Leu Pro Val Arg Phe Leu Phe Thr Asp Tyr Asn Arg Leu Ser Ser Val 
        595                 600                 605             


Gly Gly Glu Thr Ser Leu Ala Glu Met Ile Ala Thr Leu Ser Asp Ala 
    610                 615                 620                 


Cys Glu Arg Glu Phe Gly Phe Leu Ala Thr Arg Leu Phe Arg Val Phe 
625                 630                 635                 640 


Lys Thr Glu Asp Thr Gln Gly Lys Lys Lys Trp Lys Lys Thr Cys Cys 
                645                 650                 655     


Leu Pro Ser Phe Val Ile Phe Leu Phe Ile Ile Gly Cys Ile Ile Ser 
            660                 665                 670         


Gly Ile Thr Leu Leu Ala Ile Phe Arg Val Asp Pro Lys His Leu Thr 
        675                 680                 685             


Val Asn Ala Val Leu Ile Ser Ile Ala Ser Val Val Gly Leu Ala Phe 
    690                 695                 700                 


Val Leu Asn Cys Arg Thr Trp Trp Gln Val Leu Asp Ser Leu Leu Asn 
705                 710                 715                 720 


Ser Gln Arg Lys Arg Leu His Asn Ala Ala Ser Lys Leu His Lys Leu 
                725                 730                 735     


Lys Ser Glu Gly Phe Met Lys Val Leu Lys Cys Glu Val Glu Leu Met 
            740                 745                 750         


Ala Arg Met Ala Lys Thr Ile Asp Ser Phe Thr Gln Asn Gln Thr Arg 
        755                 760                 765             


Leu Val Val Ile Ile Asp Gly Leu Asp Ala Cys Glu Gln Asp Lys Val 
    770                 775                 780                 


Leu Gln Met Leu Asp Thr Val Arg Val Leu Phe Ser Lys Gly Pro Phe 
785                 790                 795                 800 


Ile Ala Ile Phe Ala Ser Asp Pro His Ile Ile Ile Lys Ala Ile Asn 
                805                 810                 815     


Gln Asn Leu Asn Ser Val Leu Arg Asp Ser Asn Ile Asn Gly His Asp 
            820                 825                 830         


Tyr Met Arg Asn Ile Val His Leu Pro Val Phe Leu Asn Ser Arg Gly 
        835                 840                 845             


Leu Ser Asn Ala Arg Lys Phe Leu Val Thr Ser Ala Thr Asn Gly Asp 
    850                 855                 860                 


Val Pro Cys Ser Asp Thr Thr Gly Ile Gln Glu Asp Ala Asp Arg Arg 
865                 870                 875                 880 


Val Ser Gln Asn Ser Leu Gly Glu Met Thr Lys Leu Gly Ser Lys Thr 
                885                 890                 895     


Ala Leu Asn Arg Arg Asp Thr Tyr Arg Arg Arg Gln Met Gln Arg Thr 
            900                 905                 910         


Ile Thr Arg Gln Met Ser Phe Asp Leu Thr Lys Leu Leu Val Thr Glu 
        915                 920                 925             


Asp Trp Phe Ser Asp Ile Ser Pro Gln Thr Met Arg Arg Leu Leu Asn 
    930                 935                 940                 


Ile Val Ser Val Thr Gly Arg Leu Leu Arg Ala Asn Gln Ile Ser Phe 
945                 950                 955                 960 


Asn Trp Asp Arg Leu Ala Ser Trp Ile Asn Leu Thr Glu Gln Trp Pro 
                965                 970                 975     


Tyr Arg Thr Ser Trp Leu Ile Leu Tyr Leu Glu Glu Thr Glu Gly Ile 
            980                 985                 990         


Pro Asp Gln Met Thr Leu Lys Thr  Ile Tyr Glu Arg Ile  Ser Lys Asn 
        995                 1000                 1005             


Ile Pro  Thr Thr Lys Asp Val  Glu Pro Leu Leu Glu  Ile Asp Gly 
    1010                 1015                 1020             


Asp Ile  Arg Asn Phe Glu Val  Phe Leu Ser Ser Arg  Thr Pro Val 
    1025                 1030                 1035             


Leu Val  Ala Arg Asp Val Lys  Val Phe Leu Pro Cys  Thr Val Asn 
    1040                 1045                 1050             


Leu Asp  Pro Lys Leu Arg Glu  Ile Ile Ala Asp Val  Arg Ala Ala 
    1055                 1060                 1065             


Arg Glu  Gln Ile Ser Ile Gly  Gly Leu Ala Tyr Pro  Pro Leu Pro 
    1070                 1075                 1080             


Leu His  Glu Gly Pro Pro Arg  Ala Pro Ser Gly Tyr  Ser Gln Pro 
    1085                 1090                 1095             


Pro Ser  Val Cys Ser Ser Thr  Ser Phe Asn Gly Pro  Phe Ala Gly 
    1100                 1105                 1110             


Gly Val  Val Ser Pro Gln Pro  His Ser Ser Tyr Tyr  Ser Gly Met 
    1115                 1120                 1125             


Thr Gly  Pro Gln His Pro Phe  Tyr Asn Arg Pro Phe  Phe Ala Pro 
    1130                 1135                 1140             


Tyr Leu  Tyr Thr Pro Arg Tyr  Tyr Pro Gly Gly Ser  Gln His Leu 
    1145                 1150                 1155             


Ile Ser  Arg Pro Ser Val Lys  Thr Ser Leu Pro Arg  Asp Gln Asn 
    1160                 1165                 1170             


Asn Gly  Leu Glu Val Ile Lys  Glu Asp Ala Ala Glu  Gly Leu Ser 
    1175                 1180                 1185             


Ser Pro  Thr Asp Ser Ser Arg  Gly Ser Gly Pro Ala  Pro Gly Pro 
    1190                 1195                 1200             


Val Val  Leu Leu Asn Ser Leu  Asn Val Asp Ala Val  Cys Glu Lys 
    1205                 1210                 1215             


Leu Lys  Gln Ile Glu Gly Leu  Asp Gln Ser Met Leu  Pro Gln Tyr 
    1220                 1225                 1230             


Cys Thr  Thr Ile Lys Lys Ala  Asn Ile Asn Gly Arg  Val Leu Ala 
    1235                 1240                 1245             


Gln Cys  Asn Ile Asp Glu Leu  Lys Lys Glu Met Asn  Met Asn Phe 
    1250                 1255                 1260             


Gly Asp  Trp His Leu Phe Arg  Ser Thr Val Leu Glu  Met Arg Asn 
    1265                 1270                 1275             


Ala Glu  Ser His Val Val Pro  Glu Asp Pro Arg Phe  Leu Ser Glu 
    1280                 1285                 1290             


Ser Ser  Ser Gly Pro Ala Pro  His Gly Glu Pro Ala  Arg Arg Ala 
    1295                 1300                 1305             


Ser His  Asn Glu Leu Pro His  Thr Glu Leu Ser Ser  Gln Thr Pro 
    1310                 1315                 1320             


Tyr Thr  Leu Asn Phe Ser Phe  Glu Glu Leu Asn Thr  Leu Gly Leu 
    1325                 1330                 1335             


Asp Glu  Gly Ala Pro Arg His  Ser Asn Leu Ser Trp  Gln Ser Gln 
    1340                 1345                 1350             


Thr Arg  Arg Thr Pro Ser Leu  Ser Ser Leu Asn Ser  Gln Asp Ser 
    1355                 1360                 1365             


Ser Ile  Glu Ile Ser Lys Leu  Thr Asp Lys Val Gln  Ala Glu Tyr 
    1370                 1375                 1380             


Arg Asp  Ala Tyr Arg Glu Tyr  Ile Ala Gln Met Ser  Gln Leu Glu 
    1385                 1390                 1395             


Gly Gly  Pro Gly Ser Thr Thr  Ile Ser Gly Arg Ser  Ser Pro His 
    1400                 1405                 1410             


Ser Thr  Tyr Tyr Met Gly Gln  Ser Ser Ser Gly Gly  Ser Ile His 
    1415                 1420                 1425             


Ser Asn  Leu Glu Gln Glu Lys  Gly Lys Asp Ser Glu  Pro Lys Pro 
    1430                 1435                 1440             


Asp Asp  Gly Arg Lys Ser Phe  Leu Met Lys Arg Gly  Asp Val Ile 
    1445                 1450                 1455             


Asp Tyr  Ser Ser Ser Gly Val  Ser Thr Asn Asp Ala  Ser Pro Leu 
    1460                 1465                 1470             


Asp Pro  Ile Thr Glu Glu Asp  Glu Lys Ser Asp Gln  Ser Gly Ser 
    1475                 1480                 1485             


Lys Leu  Leu Pro Gly Lys Lys  Ser Ser Glu Arg Ser  Ser Leu Phe 
    1490                 1495                 1500             


Gln Thr  Asp Leu Lys Leu Lys  Gly Ser Gly Leu Arg  Tyr Gln Lys 
    1505                 1510                 1515             


Leu Pro  Ser Asp Glu Asp Glu  Ser Gly Thr Glu Glu  Ser Asp Asn 
    1520                 1525                 1530             


Thr Pro  Leu Leu Lys Asp Asp  Lys Asp Arg Lys Ala  Glu Gly Lys 
    1535                 1540                 1545             


Val Glu  Arg Val Pro Lys Ser  Pro Glu His Ser Ala  Glu Pro Ile 
    1550                 1555                 1560             


Arg Thr  Phe Ile Lys Ala Lys  Glu Tyr Leu Ser Asp  Ala Leu Leu 
    1565                 1570                 1575             


Asp Lys  Lys Asp Ser Ser Asp  Ser Gly Val Arg Ser  Ser Glu Ser 
    1580                 1585                 1590             


Ser Pro  Asn His Ser Leu His  Asn Glu Val Ala Asp  Asp Ser Gln 
    1595                 1600                 1605             


Leu Glu  Lys Ala Asn Leu Ile  Glu Leu Glu Asp Asp  Ser His Ser 
    1610                 1615                 1620             


Gly Lys  Arg Gly Ile Pro His  Ser Leu Ser Gly Leu  Gln Asp Pro 
    1625                 1630                 1635             


Ile Ile  Ala Arg Met Ser Ile  Cys Ser Glu Asp Lys  Lys Ser Pro 
    1640                 1645                 1650             


Ser Glu  Cys Ser Leu Ile Ala  Ser Ser Pro Glu Glu  Asn Trp Pro 
    1655                 1660                 1665             


Ala Cys  Gln Lys Ala Tyr Asn  Leu Asn Arg Thr Pro  Ser Thr Val 
    1670                 1675                 1680             


Thr Leu  Asn Asn Asn Ser Ala  Pro Ala Asn Arg Ala  Asn Gln Asn 
    1685                 1690                 1695             


Phe Asp  Glu Met Glu Gly Ile  Arg Glu Thr Ser Gln  Val Ile Leu 
    1700                 1705                 1710             


Arg Pro  Ser Ser Ser Pro Asn  Pro Thr Thr Ile Gln  Asn Glu Asn 
    1715                 1720                 1725             


Leu Lys  Ser Met Thr His Lys  Arg Ser Gln Arg Ser  Ser Tyr Thr 
    1730                 1735                 1740             


Arg Leu  Ser Lys Asp Pro Pro  Glu Leu His Ala Ala  Ala Ser Ser 
    1745                 1750                 1755             


Glu Ser  Thr Gly Phe Gly Glu  Glu Arg Glu Ser Ile  Leu 
    1760                 1765                 1770     


<210>  5868
<211>  1056
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF11__Homo_sapiens__NP_004514

<400>  5868

Met Ala Ser Gln Pro Asn Ser Ser Ala Lys Lys Lys Glu Glu Lys Gly 
1               5                   10                  15      


Lys Asn Ile Gln Val Val Val Arg Cys Arg Pro Phe Asn Leu Ala Glu 
            20                  25                  30          


Arg Lys Ala Ser Ala His Ser Ile Val Glu Cys Asp Pro Val Arg Lys 
        35                  40                  45              


Glu Val Ser Val Arg Thr Gly Gly Leu Ala Asp Lys Ser Ser Arg Lys 
    50                  55                  60                  


Thr Tyr Thr Phe Asp Met Val Phe Gly Ala Ser Thr Lys Gln Ile Asp 
65                  70                  75                  80  


Val Tyr Arg Ser Val Val Cys Pro Ile Leu Asp Glu Val Ile Met Gly 
                85                  90                  95      


Tyr Asn Cys Thr Ile Phe Ala Tyr Gly Gln Thr Gly Thr Gly Lys Thr 
            100                 105                 110         


Phe Thr Met Glu Gly Glu Arg Ser Pro Asn Glu Glu Tyr Thr Trp Glu 
        115                 120                 125             


Glu Asp Pro Leu Ala Gly Ile Ile Pro Arg Thr Leu His Gln Ile Phe 
    130                 135                 140                 


Glu Lys Leu Thr Asp Asn Gly Thr Glu Phe Ser Val Lys Val Ser Leu 
145                 150                 155                 160 


Leu Glu Ile Tyr Asn Glu Glu Leu Phe Asp Leu Leu Asn Pro Ser Ser 
                165                 170                 175     


Asp Val Ser Glu Arg Leu Gln Met Phe Asp Asp Pro Arg Asn Lys Arg 
            180                 185                 190         


Gly Val Ile Ile Lys Gly Leu Glu Glu Ile Thr Val His Asn Lys Asp 
        195                 200                 205             


Glu Val Tyr Gln Ile Leu Glu Lys Gly Ala Ala Lys Arg Thr Thr Ala 
    210                 215                 220                 


Ala Thr Leu Met Asn Ala Tyr Ser Ser Arg Ser His Ser Val Phe Ser 
225                 230                 235                 240 


Val Thr Ile His Met Lys Glu Thr Thr Ile Asp Gly Glu Glu Leu Val 
                245                 250                 255     


Lys Ile Gly Lys Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Asn Ile 
            260                 265                 270         


Gly Arg Ser Gly Ala Val Asp Lys Arg Ala Arg Glu Ala Gly Asn Ile 
        275                 280                 285             


Asn Gln Ser Leu Leu Thr Leu Gly Arg Val Ile Thr Ala Leu Val Glu 
    290                 295                 300                 


Arg Thr Pro His Val Pro Tyr Arg Glu Ser Lys Leu Thr Arg Ile Leu 
305                 310                 315                 320 


Gln Asp Ser Leu Gly Gly Arg Thr Arg Thr Ser Ile Ile Ala Thr Ile 
                325                 330                 335     


Ser Pro Ala Ser Leu Asn Leu Glu Glu Thr Leu Ser Thr Leu Glu Tyr 
            340                 345                 350         


Ala His Arg Ala Lys Asn Ile Leu Asn Lys Pro Glu Val Asn Gln Lys 
        355                 360                 365             


Leu Thr Lys Lys Ala Leu Ile Lys Glu Tyr Thr Glu Glu Ile Glu Arg 
    370                 375                 380                 


Leu Lys Arg Asp Leu Ala Ala Ala Arg Glu Lys Asn Gly Val Tyr Ile 
385                 390                 395                 400 


Ser Glu Glu Asn Phe Arg Val Met Ser Gly Lys Leu Thr Val Gln Glu 
                405                 410                 415     


Glu Gln Ile Val Glu Leu Ile Glu Lys Ile Gly Ala Val Glu Glu Glu 
            420                 425                 430         


Leu Asn Arg Val Thr Glu Leu Phe Met Asp Asn Lys Asn Glu Leu Asp 
        435                 440                 445             


Gln Cys Lys Ser Asp Leu Gln Asn Lys Thr Gln Glu Leu Glu Thr Thr 
    450                 455                 460                 


Gln Lys His Leu Gln Glu Thr Lys Leu Gln Leu Val Lys Glu Glu Tyr 
465                 470                 475                 480 


Ile Thr Ser Ala Leu Glu Ser Thr Glu Glu Lys Leu His Asp Ala Ala 
                485                 490                 495     


Ser Lys Leu Leu Asn Thr Val Glu Glu Thr Thr Lys Asp Val Ser Gly 
            500                 505                 510         


Leu His Ser Lys Leu Asp Arg Lys Lys Ala Val Asp Gln His Asn Ala 
        515                 520                 525             


Glu Ala Gln Asp Ile Phe Gly Lys Asn Leu Asn Ser Leu Phe Asn Asn 
    530                 535                 540                 


Met Glu Glu Leu Ile Lys Asp Gly Ser Ser Lys Gln Lys Ala Met Leu 
545                 550                 555                 560 


Glu Val His Lys Thr Leu Phe Gly Asn Leu Leu Ser Ser Ser Val Ser 
                565                 570                 575     


Ala Leu Asp Thr Ile Thr Thr Val Ala Leu Gly Ser Leu Thr Ser Ile 
            580                 585                 590         


Pro Glu Asn Val Ser Thr His Val Ser Gln Ile Phe Asn Met Ile Leu 
        595                 600                 605             


Lys Glu Gln Ser Leu Ala Ala Glu Ser Lys Thr Val Leu Gln Glu Leu 
    610                 615                 620                 


Ile Asn Val Leu Lys Thr Asp Leu Leu Ser Ser Leu Glu Met Ile Leu 
625                 630                 635                 640 


Ser Pro Thr Val Val Ser Ile Leu Lys Ile Asn Ser Gln Leu Lys His 
                645                 650                 655     


Ile Phe Lys Thr Ser Leu Thr Val Ala Asp Lys Ile Glu Asp Gln Lys 
            660                 665                 670         


Lys Glu Leu Asp Gly Phe Leu Ser Ile Leu Cys Asn Asn Leu His Glu 
        675                 680                 685             


Leu Gln Glu Asn Thr Ile Cys Ser Leu Val Glu Ser Gln Lys Gln Cys 
    690                 695                 700                 


Gly Asn Leu Thr Glu Asp Leu Lys Thr Ile Lys Gln Thr His Ser Gln 
705                 710                 715                 720 


Glu Leu Cys Lys Leu Met Asn Leu Trp Thr Glu Arg Phe Cys Ala Leu 
                725                 730                 735     


Glu Glu Lys Cys Glu Asn Ile Gln Lys Pro Leu Ser Ser Val Gln Glu 
            740                 745                 750         


Asn Ile Gln Gln Lys Ser Lys Asp Ile Val Asn Lys Met Thr Phe His 
        755                 760                 765             


Ser Gln Lys Phe Cys Ala Asp Ser Asp Gly Phe Ser Gln Glu Leu Arg 
    770                 775                 780                 


Asn Phe Asn Gln Glu Gly Thr Lys Leu Val Glu Glu Ser Val Lys His 
785                 790                 795                 800 


Ser Asp Lys Leu Asn Gly Asn Leu Glu Lys Ile Ser Gln Glu Thr Glu 
                805                 810                 815     


Gln Arg Cys Glu Ser Leu Asn Thr Arg Thr Val Tyr Phe Ser Glu Gln 
            820                 825                 830         


Trp Val Ser Ser Leu Asn Glu Arg Glu Gln Glu Leu His Asn Leu Leu 
        835                 840                 845             


Glu Val Val Ser Gln Cys Cys Glu Ala Ser Ser Ser Asp Ile Thr Glu 
    850                 855                 860                 


Lys Ser Asp Gly Arg Lys Ala Ala His Glu Lys Gln His Asn Ile Phe 
865                 870                 875                 880 


Leu Asp Gln Met Thr Ile Asp Glu Asp Lys Leu Ile Ala Gln Asn Leu 
                885                 890                 895     


Glu Leu Asn Glu Thr Ile Lys Ile Gly Leu Thr Lys Leu Asn Cys Phe 
            900                 905                 910         


Leu Glu Gln Asp Leu Lys Leu Asp Ile Pro Thr Gly Thr Thr Pro Gln 
        915                 920                 925             


Arg Lys Ser Tyr Leu Tyr Pro Ser Thr Leu Val Arg Thr Glu Pro Arg 
    930                 935                 940                 


Glu His Leu Leu Asp Gln Leu Lys Arg Lys Gln Pro Glu Leu Leu Met 
945                 950                 955                 960 


Met Leu Asn Cys Ser Glu Asn Asn Lys Glu Glu Thr Ile Pro Asp Val 
                965                 970                 975     


Asp Val Glu Glu Ala Val Leu Gly Gln Tyr Thr Glu Glu Pro Leu Ser 
            980                 985                 990         


Gln Glu Pro Ser Val Asp Ala Gly  Val Asp Cys Ser Ser  Ile Gly Gly 
        995                 1000                 1005             


Val Pro  Phe Phe Gln His Lys  Lys Ser His Gly Lys  Asp Lys Glu 
    1010                 1015                 1020             


Asn Arg  Gly Ile Asn Thr Leu  Glu Arg Ser Lys Val  Glu Glu Thr 
    1025                 1030                 1035             


Thr Glu  His Leu Val Thr Lys  Ser Arg Leu Pro Leu  Arg Ala Gln 
    1040                 1045                 1050             


Ile Asn  Leu 
    1055     


<210>  5869
<211>  1770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF13A__Homo_sapiens__NP_001099036

<400>  5869

Met Ser Asp Thr Lys Val Lys Val Ala Val Arg Val Arg Pro Met Asn 
1               5                   10                  15      


Arg Arg Glu Leu Glu Leu Asn Thr Lys Cys Val Val Glu Met Glu Gly 
            20                  25                  30          


Asn Gln Thr Val Leu His Pro Pro Pro Ser Asn Thr Lys Gln Gly Glu 
        35                  40                  45              


Arg Lys Pro Pro Lys Val Phe Ala Phe Asp Tyr Cys Phe Trp Ser Met 
    50                  55                  60                  


Asp Glu Ser Asn Thr Thr Lys Tyr Ala Gly Gln Glu Val Val Phe Lys 
65                  70                  75                  80  


Cys Leu Gly Glu Gly Ile Leu Glu Lys Ala Phe Gln Gly Tyr Asn Ala 
                85                  90                  95      


Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Phe Ser Met 
            100                 105                 110         


Met Gly His Ala Glu Gln Leu Gly Leu Ile Pro Arg Leu Cys Cys Ala 
        115                 120                 125             


Leu Phe Lys Arg Ile Ser Leu Glu Gln Asn Glu Ser Gln Thr Phe Lys 
    130                 135                 140                 


Val Glu Val Ser Tyr Met Glu Ile Tyr Asn Glu Lys Val Arg Asp Leu 
145                 150                 155                 160 


Leu Asp Pro Lys Gly Ser Arg Gln Ser Leu Lys Val Arg Glu His Lys 
                165                 170                 175     


Val Leu Gly Pro Tyr Val Asp Gly Leu Ser Gln Leu Ala Val Thr Ser 
            180                 185                 190         


Phe Glu Asp Ile Glu Ser Leu Met Ser Glu Gly Asn Lys Ser Arg Thr 
        195                 200                 205             


Val Ala Ala Thr Asn Met Asn Glu Glu Ser Ser Arg Ser His Ala Val 
    210                 215                 220                 


Phe Asn Ile Ile Ile Thr Gln Thr Leu Tyr Asp Leu Gln Ser Gly Asn 
225                 230                 235                 240 


Ser Gly Glu Lys Val Ser Lys Val Ser Leu Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Val Ser Lys Thr Gly Ala Ala Gly Glu Arg Leu Lys Glu Gly 
            260                 265                 270         


Ser Asn Ile Asn Lys Ser Leu Thr Thr Leu Gly Leu Val Ile Ser Ser 
        275                 280                 285             


Leu Ala Asp Gln Ala Ala Gly Lys Gly Lys Ser Lys Phe Val Pro Tyr 
    290                 295                 300                 


Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Asn Leu Gly Gly Asn 
305                 310                 315                 320 


Ser Gln Thr Ser Met Ile Ala Thr Ile Ser Pro Ala Ala Asp Asn Tyr 
                325                 330                 335     


Glu Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Arg Ile 
            340                 345                 350         


Val Asn His Ala Val Val Asn Glu Asp Pro Asn Ala Lys Val Ile Arg 
        355                 360                 365             


Glu Leu Arg Glu Glu Val Glu Lys Leu Arg Glu Gln Leu Ser Gln Ala 
    370                 375                 380                 


Glu Ala Met Lys Ala Pro Glu Leu Lys Glu Lys Leu Glu Glu Ser Glu 
385                 390                 395                 400 


Lys Leu Ile Lys Glu Leu Thr Val Thr Trp Glu Glu Lys Leu Arg Lys 
                405                 410                 415     


Thr Glu Glu Ile Ala Gln Glu Arg Gln Arg Gln Leu Glu Ser Met Gly 
            420                 425                 430         


Ile Ser Leu Glu Met Ser Gly Ile Lys Val Gly Asp Asp Lys Cys Tyr 
        435                 440                 445             


Leu Val Asn Leu Asn Ala Asp Pro Ala Leu Asn Glu Leu Leu Val Tyr 
    450                 455                 460                 


Tyr Leu Lys Asp His Thr Arg Val Gly Ala Asp Thr Ser Gln Asp Ile 
465                 470                 475                 480 


Gln Leu Phe Gly Ile Gly Ile Gln Pro Gln His Cys Glu Ile Asp Ile 
                485                 490                 495     


Ala Ser Asp Gly Asp Val Thr Leu Thr Pro Lys Glu Asn Ala Arg Ser 
            500                 505                 510         


Cys Val Asn Gly Thr Leu Val Cys Ser Thr Thr Gln Leu Trp His Gly 
        515                 520                 525             


Asp Arg Ile Leu Trp Gly Asn Asn His Phe Phe Arg Ile Asn Leu Pro 
    530                 535                 540                 


Lys Arg Lys Arg Arg Asp Trp Leu Lys Asp Phe Glu Lys Glu Thr Gly 
545                 550                 555                 560 


Pro Pro Glu His Asp Leu Asp Ala Ala Ser Glu Ala Ser Ser Glu Pro 
                565                 570                 575     


Asp Tyr Asn Tyr Glu Phe Ala Gln Met Glu Val Ile Met Lys Thr Leu 
            580                 585                 590         


Asn Ser Asn Asp Pro Val Gln Asn Val Val Gln Val Leu Glu Lys Gln 
        595                 600                 605             


Tyr Leu Glu Glu Lys Arg Ser Ala Leu Glu Glu Gln Arg Leu Met Tyr 
    610                 615                 620                 


Glu Arg Glu Leu Glu Gln Leu Arg Gln Gln Leu Ser Pro Asp Arg Gln 
625                 630                 635                 640 


Pro Gln Ser Ser Gly Pro Asp Arg Leu Ala Tyr Ser Ser Gln Thr Ala 
                645                 650                 655     


Gln Gln Lys Val Thr Gln Trp Ala Glu Glu Arg Asp Glu Leu Phe Arg 
            660                 665                 670         


Gln Ser Leu Ala Lys Leu Arg Glu Gln Leu Val Lys Ala Asn Thr Leu 
        675                 680                 685             


Val Arg Glu Ala Asn Phe Leu Ala Glu Glu Met Ser Lys Leu Thr Asp 
    690                 695                 700                 


Tyr Gln Val Thr Leu Gln Ile Pro Ala Ala Asn Leu Ser Ala Asn Arg 
705                 710                 715                 720 


Lys Arg Gly Ala Ile Val Ser Glu Pro Ala Ile Gln Val Arg Arg Lys 
                725                 730                 735     


Gly Lys Ser Thr Gln Val Trp Thr Ile Glu Lys Leu Glu Asn Lys Leu 
            740                 745                 750         


Ile Asp Met Arg Asp Leu Tyr Gln Glu Trp Lys Glu Lys Val Pro Glu 
        755                 760                 765             


Ala Lys Arg Leu Tyr Gly Lys Arg Gly Asp Pro Phe Tyr Glu Ala Gln 
    770                 775                 780                 


Glu Asn His Asn Leu Ile Gly Val Ala Asn Val Phe Leu Glu Cys Leu 
785                 790                 795                 800 


Phe Cys Asp Val Lys Leu Gln Tyr Ala Val Pro Ile Ile Ser Gln Gln 
                805                 810                 815     


Gly Glu Val Ala Gly Arg Leu His Val Glu Val Met Arg Val Thr Gly 
            820                 825                 830         


Ala Val Pro Glu Arg Val Val Glu Asp Asp Ser Ser Glu Asn Ser Ser 
        835                 840                 845             


Glu Ser Gly Ser Leu Glu Val Val Asp Ser Ser Gly Glu Ile Ile His 
    850                 855                 860                 


Arg Val Lys Lys Leu Thr Cys Arg Val Lys Ile Lys Glu Ala Thr Gly 
865                 870                 875                 880 


Leu Pro Leu Asn Leu Ser Asn Phe Val Phe Cys Gln Tyr Thr Phe Trp 
                885                 890                 895     


Asp Gln Cys Glu Ser Thr Val Ala Ala Pro Val Val Asp Pro Glu Val 
            900                 905                 910         


Pro Ser Pro Gln Ser Lys Asp Ala Gln Tyr Thr Val Thr Phe Ser His 
        915                 920                 925             


Cys Lys Asp Tyr Val Val Asn Val Thr Glu Glu Phe Leu Glu Phe Ile 
    930                 935                 940                 


Ser Asp Gly Ala Leu Ala Ile Glu Val Trp Gly His Arg Cys Ala Gly 
945                 950                 955                 960 


Asn Gly Ser Ser Ile Trp Glu Val Asp Ser Leu His Ala Lys Thr Arg 
                965                 970                 975     


Thr Leu His Asp Arg Trp Asn Glu Val Thr Arg Arg Ile Glu Met Trp 
            980                 985                 990         


Ile Ser Ile Leu Glu Leu Asn Glu  Leu Gly Glu Tyr Ala  Ala Val Glu 
        995                 1000                 1005             


Leu His  Gln Ala Lys Asp Val  Asn Thr Gly Gly Ile  Phe Gln Leu 
    1010                 1015                 1020             


Arg Gln  Gly His Ser Arg Arg  Val Gln Val Thr Val  Lys Pro Val 
    1025                 1030                 1035             


Gln His  Ser Gly Thr Leu Pro  Leu Met Val Glu Ala  Ile Leu Ser 
    1040                 1045                 1050             


Val Ser  Ile Gly Cys Val Thr  Ala Arg Ser Thr Lys  Leu Gln Arg 
    1055                 1060                 1065             


Gly Leu  Asp Ser Tyr Gln Arg  Asp Asp Glu Asp Gly  Asp Asp Met 
    1070                 1075                 1080             


Asp Ser  Tyr Gln Glu Glu Asp  Leu Asn Cys Val Arg  Glu Arg Trp 
    1085                 1090                 1095             


Ser Asp  Ala Leu Ile Lys Arg  Arg Glu Tyr Leu Asp  Glu Gln Ile 
    1100                 1105                 1110             


Lys Lys  Val Ser Asn Lys Thr  Glu Lys Thr Glu Asp  Asp Val Glu 
    1115                 1120                 1125             


Arg Glu  Ala Gln Leu Val Glu  Gln Trp Val Gly Leu  Thr Glu Glu 
    1130                 1135                 1140             


Arg Asn  Ala Val Leu Val Pro  Ala Pro Gly Ser Gly  Ile Pro Gly 
    1145                 1150                 1155             


Ala Pro  Ala Asp Trp Ile Pro  Pro Pro Gly Met Glu  Thr His Ile 
    1160                 1165                 1170             


Pro Val  Leu Phe Leu Asp Leu  Asn Ala Asp Asp Leu  Ser Ala Asn 
    1175                 1180                 1185             


Glu Gln  Leu Val Gly Pro His  Ala Ser Gly Val Asn  Ser Ile Leu 
    1190                 1195                 1200             


Pro Lys  Glu His Gly Ser Gln  Phe Phe Tyr Leu Pro  Ile Ile Lys 
    1205                 1210                 1215             


His Ser  Asp Asp Glu Val Ser  Ala Thr Ala Ser Trp  Asp Ser Ser 
    1220                 1225                 1230             


Val His  Asp Ser Val His Leu  Asn Arg Val Thr Pro  Gln Asn Glu 
    1235                 1240                 1245             


Arg Ile  Tyr Leu Ile Val Lys  Thr Thr Val Gln Leu  Ser His Pro 
    1250                 1255                 1260             


Ala Ala  Met Glu Leu Val Leu  Arg Lys Arg Ile Ala  Ala Asn Ile 
    1265                 1270                 1275             


Tyr Asn  Lys Gln Ser Phe Thr  Gln Ser Leu Lys Arg  Arg Ile Ser 
    1280                 1285                 1290             


Leu Lys  Asn Ile Phe Tyr Ser  Cys Gly Val Thr Tyr  Glu Ile Val 
    1295                 1300                 1305             


Ser Asn  Ile Pro Lys Ala Thr  Glu Glu Ile Glu Asp  Arg Glu Thr 
    1310                 1315                 1320             


Leu Ala  Leu Leu Ala Ala Arg  Ser Glu Asn Glu Gly  Thr Ser Asp 
    1325                 1330                 1335             


Gly Glu  Thr Tyr Ile Glu Lys  Tyr Thr Arg Gly Val  Leu Gln Val 
    1340                 1345                 1350             


Glu Asn  Ile Leu Ser Leu Glu  Arg Leu Arg Gln Ala  Val Thr Val 
    1355                 1360                 1365             


Lys Glu  Ala Leu Ser Thr Lys  Ala Arg His Ile Arg  Arg Ser Leu 
    1370                 1375                 1380             


Ser Thr  Pro Asn Val His Asn  Val Ser Ser Ser Arg  Pro Asp Leu 
    1385                 1390                 1395             


Ser Gly  Phe Asp Glu Asp Asp  Lys Gly Trp Pro Glu  Asn Gln Leu 
    1400                 1405                 1410             


Asp Met  Ser Asp Tyr Ser Ser  Ser Tyr Gln Asp Val  Ala Cys Tyr 
    1415                 1420                 1425             


Gly Thr  Leu Pro Arg Asp Ser  Pro Arg Arg Asn Lys  Glu Gly Cys 
    1430                 1435                 1440             


Thr Ser  Glu Thr Pro His Ala  Leu Thr Val Ser Pro  Phe Lys Ala 
    1445                 1450                 1455             


Phe Ser  Pro Gln Pro Pro Lys  Phe Phe Lys Pro Leu  Met Pro Val 
    1460                 1465                 1470             


Lys Glu  Glu His Lys Lys Arg  Ile Ala Leu Glu Ala  Arg Pro Leu 
    1475                 1480                 1485             


Leu Ser  Gln Glu Asp Ser Glu  Glu Glu Glu Asn Glu  Leu Glu Ala 
    1490                 1495                 1500             


Ile Asn  Arg Lys Leu Ile Ser  Ser Gln Pro Tyr Val  Pro Val Glu 
    1505                 1510                 1515             


Phe Ala  Asp Phe Ser Val Tyr  Asn Ala Ser Leu Glu  Asn Arg Glu 
    1520                 1525                 1530             


Trp Phe  Ser Ser Lys Val Asp  Leu Ser Asn Ser Arg  Val Leu Glu 
    1535                 1540                 1545             


Lys Glu  Val Ser Arg Ser Pro  Thr Thr Ser Ser Ile  Thr Ser Gly 
    1550                 1555                 1560             


Tyr Phe  Ser His Ser Ala Ser  Asn Ala Thr Leu Ser  Asp Met Val 
    1565                 1570                 1575             


Val Pro  Ser Ser Asp Ser Ser  Asp Gln Leu Ala Ile  Gln Thr Lys 
    1580                 1585                 1590             


Asp Ala  Asp Ser Thr Glu His  Ser Thr Pro Ser Leu  Val His Asp 
    1595                 1600                 1605             


Phe Arg  Pro Ser Ser Asn Lys  Glu Leu Thr Glu Val  Glu Lys Gly 
    1610                 1615                 1620             


Leu Val  Lys Asp Lys Ile Ile  Val Val Pro Leu Lys  Glu Asn Ser 
    1625                 1630                 1635             


Ala Leu  Ala Lys Gly Ser Pro  Ser Ser Gln Ser Ile  Pro Glu Lys 
    1640                 1645                 1650             


Asn Ser  Lys Ser Leu Cys Arg  Thr Gly Ser Cys Ser  Glu Leu Asp 
    1655                 1660                 1665             


Ala Cys  Pro Ser Lys Ile Ser  Gln Pro Ala Arg Gly  Phe Cys Pro 
    1670                 1675                 1680             


Arg Glu  Val Thr Val Glu His  Thr Thr Asn Ile Leu  Glu Asp His 
    1685                 1690                 1695             


Ser Phe  Thr Glu Phe Met Gly  Val Ser Glu Gly Lys  Asp Phe Asp 
    1700                 1705                 1710             


Gly Leu  Thr Asp Ser Ser Ala  Gly Glu Leu Ser Ser  Arg Arg Ser 
    1715                 1720                 1725             


Leu Pro  Asn Lys Thr Gly Gly  Lys Thr Val Ser Asp  Gly Leu His 
    1730                 1735                 1740             


His Pro  Ser Gln Leu His Ser  Lys Leu Glu Asn Asp  Gln Val Ile 
    1745                 1750                 1755             


Ile Pro  Glu Ala Ala Phe Trp  Val Leu Cys Cys Gln  
    1760                 1765                 1770 


<210>  5870
<211>  1648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF14__Homo_sapiens__NP_055690

<400>  5870

Met Ser Leu His Ser Thr His Asn Arg Asn Asn Ser Gly Asp Ile Leu 
1               5                   10                  15      


Asp Ile Pro Ser Ser Gln Asn Ser Ser Ser Leu Asn Ala Leu Thr His 
            20                  25                  30          


Ser Ser Arg Leu Lys Leu His Leu Lys Ser Asp Met Ser Glu Cys Glu 
        35                  40                  45              


Asn Asp Asp Pro Leu Leu Arg Ser Ala Gly Lys Val Arg Asp Ile Asn 
    50                  55                  60                  


Arg Thr Tyr Val Ile Ser Ala Ser Arg Lys Thr Ala Asp Met Pro Leu 
65                  70                  75                  80  


Thr Pro Asn Pro Val Gly Arg Leu Ala Leu Gln Arg Arg Thr Thr Arg 
                85                  90                  95      


Asn Lys Glu Ser Ser Leu Leu Val Ser Glu Leu Glu Asp Thr Thr Glu 
            100                 105                 110         


Lys Thr Ala Glu Thr Arg Leu Thr Leu Gln Arg Arg Ala Lys Thr Asp 
        115                 120                 125             


Ser Ala Glu Lys Trp Lys Thr Ala Glu Ile Asp Ser Val Lys Met Thr 
    130                 135                 140                 


Leu Asn Val Gly Gly Glu Thr Glu Asn Asn Gly Val Ser Lys Glu Ser 
145                 150                 155                 160 


Arg Thr Asn Val Arg Ile Val Asn Asn Ala Lys Asn Ser Phe Val Ala 
                165                 170                 175     


Ser Ser Val Pro Leu Asp Glu Asp Pro Gln Val Ile Glu Met Met Ala 
            180                 185                 190         


Asp Lys Lys Tyr Lys Glu Thr Phe Ser Ala Pro Ser Arg Ala Asn Glu 
        195                 200                 205             


Asn Val Ala Leu Lys Tyr Ser Ser Asn Arg Pro Pro Ile Ala Ser Leu 
    210                 215                 220                 


Ser Gln Thr Glu Val Val Arg Ser Gly His Leu Thr Thr Lys Pro Thr 
225                 230                 235                 240 


Gln Ser Lys Leu Asp Ile Lys Val Leu Gly Thr Gly Asn Leu Tyr His 
                245                 250                 255     


Arg Ser Ile Gly Lys Glu Ile Ala Lys Thr Ser Asn Lys Phe Gly Ser 
            260                 265                 270         


Leu Glu Lys Arg Thr Pro Thr Lys Cys Thr Thr Glu His Lys Leu Thr 
        275                 280                 285             


Thr Lys Cys Ser Leu Pro Gln Leu Lys Ser Pro Ala Pro Ser Ile Leu 
    290                 295                 300                 


Lys Asn Arg Met Ser Asn Leu Gln Val Lys Gln Arg Pro Lys Ser Ser 
305                 310                 315                 320 


Phe Leu Ala Asn Lys Gln Glu Arg Ser Ala Glu Asn Thr Ile Leu Pro 
                325                 330                 335     


Glu Glu Glu Thr Val Val Gln Asn Thr Ser Ala Gly Lys Asp Pro Leu 
            340                 345                 350         


Lys Val Glu Asn Ser Gln Val Thr Val Ala Val Arg Val Arg Pro Phe 
        355                 360                 365             


Thr Lys Arg Glu Lys Ile Glu Lys Ala Ser Gln Val Val Phe Met Ser 
    370                 375                 380                 


Gly Lys Glu Ile Thr Val Glu His Pro Asp Thr Lys Gln Val Tyr Asn 
385                 390                 395                 400 


Phe Ile Tyr Asp Val Ser Phe Trp Ser Phe Asp Glu Cys His Pro His 
                405                 410                 415     


Tyr Ala Ser Gln Thr Thr Val Tyr Glu Lys Leu Ala Ala Pro Leu Leu 
            420                 425                 430         


Glu Arg Ala Phe Glu Gly Phe Asn Thr Cys Leu Phe Ala Tyr Gly Gln 
        435                 440                 445             


Thr Gly Ser Gly Lys Ser Tyr Thr Met Met Gly Phe Ser Glu Glu Pro 
    450                 455                 460                 


Gly Ile Ile Pro Arg Phe Cys Glu Asp Leu Phe Ser Gln Val Ala Arg 
465                 470                 475                 480 


Lys Gln Thr Gln Glu Val Ser Tyr His Ile Glu Met Ser Phe Phe Glu 
                485                 490                 495     


Val Tyr Asn Glu Lys Ile His Asp Leu Leu Val Cys Lys Asp Glu Asn 
            500                 505                 510         


Gly Gln Arg Lys Gln Pro Leu Arg Val Arg Glu His Pro Val Tyr Gly 
        515                 520                 525             


Pro Tyr Val Glu Ala Leu Ser Met Asn Ile Val Ser Ser Tyr Ala Asp 
    530                 535                 540                 


Ile Gln Ser Trp Leu Glu Leu Gly Asn Lys Gln Arg Ala Thr Ala Ala 
545                 550                 555                 560 


Thr Gly Met Asn Asp Lys Ser Ser Arg Ser His Ser Val Phe Thr Leu 
                565                 570                 575     


Val Met Thr Gln Thr Lys Thr Glu Phe Val Glu Gly Glu Glu His Asp 
            580                 585                 590         


His Arg Ile Thr Ser Arg Ile Asn Leu Ile Asp Leu Ala Gly Ser Glu 
        595                 600                 605             


Arg Cys Ser Thr Ala His Thr Asn Gly Asp Arg Leu Lys Glu Gly Val 
    610                 615                 620                 


Ser Ile Asn Lys Ser Leu Leu Thr Leu Gly Lys Val Ile Ser Ala Leu 
625                 630                 635                 640 


Ser Glu Gln Ala Asn Gln Arg Ser Val Phe Ile Pro Tyr Arg Glu Ser 
                645                 650                 655     


Val Leu Thr Trp Leu Leu Lys Glu Ser Leu Gly Gly Asn Ser Lys Thr 
            660                 665                 670         


Ala Met Ile Ala Thr Ile Ser Pro Ala Ala Ser Asn Ile Glu Glu Thr 
        675                 680                 685             


Leu Ser Thr Leu Arg Tyr Ala Asn Gln Ala Arg Leu Ile Val Asn Ile 
    690                 695                 700                 


Ala Lys Val Asn Glu Asp Met Asn Ala Lys Leu Ile Arg Glu Leu Lys 
705                 710                 715                 720 


Ala Glu Ile Ala Lys Leu Lys Ala Ala Gln Arg Asn Ser Arg Asn Ile 
                725                 730                 735     


Asp Pro Glu Arg Tyr Arg Leu Cys Arg Gln Glu Ile Thr Ser Leu Arg 
            740                 745                 750         


Met Lys Leu His Gln Gln Glu Arg Asp Met Ala Glu Met Gln Arg Val 
        755                 760                 765             


Trp Lys Glu Lys Phe Glu Gln Ala Glu Lys Arg Lys Leu Gln Glu Thr 
    770                 775                 780                 


Lys Glu Leu Gln Lys Ala Gly Ile Met Phe Gln Met Asp Asn His Leu 
785                 790                 795                 800 


Pro Asn Leu Val Asn Leu Asn Glu Asp Pro Gln Leu Ser Glu Met Leu 
                805                 810                 815     


Leu Tyr Met Ile Lys Glu Gly Thr Thr Thr Val Gly Lys Tyr Lys Pro 
            820                 825                 830         


Asn Ser Ser His Asp Ile Gln Leu Ser Gly Val Leu Ile Ala Asp Asp 
        835                 840                 845             


His Cys Thr Ile Lys Asn Phe Gly Gly Thr Val Ser Ile Ile Pro Val 
    850                 855                 860                 


Gly Glu Ala Lys Thr Tyr Val Asn Gly Lys His Ile Leu Glu Ile Thr 
865                 870                 875                 880 


Val Leu Arg His Gly Asp Arg Val Ile Leu Gly Gly Asp His Tyr Phe 
                885                 890                 895     


Arg Phe Asn His Pro Val Glu Val Gln Lys Gly Lys Arg Pro Ser Gly 
            900                 905                 910         


Arg Asp Thr Pro Ile Ser Glu Gly Pro Lys Asp Phe Glu Phe Ala Lys 
        915                 920                 925             


Asn Glu Leu Leu Met Ala Gln Arg Ser Gln Leu Glu Ala Glu Ile Lys 
    930                 935                 940                 


Glu Ala Gln Leu Lys Ala Lys Glu Glu Met Met Gln Gly Ile Gln Ile 
945                 950                 955                 960 


Ala Lys Glu Met Ala Gln Gln Glu Leu Ser Ser Gln Lys Ala Ala Tyr 
                965                 970                 975     


Glu Ser Lys Ile Lys Ala Leu Glu Ala Glu Leu Arg Glu Glu Ser Gln 
            980                 985                 990         


Arg Lys Lys Met Gln Glu Ile Asn  Asn Gln Lys Ala Asn  His Lys Ile 
        995                 1000                 1005             


Glu Glu  Leu Glu Lys Ala Lys  Gln His Leu Glu Gln  Glu Ile Tyr 
    1010                 1015                 1020             


Val Asn  Lys Lys Arg Leu Glu  Met Glu Thr Leu Ala  Thr Lys Gln 
    1025                 1030                 1035             


Ala Leu  Glu Asp His Ser Ile  Arg His Ala Arg Ile  Leu Glu Ala 
    1040                 1045                 1050             


Leu Glu  Thr Glu Lys Gln Lys  Ile Ala Lys Glu Val  Gln Ile Leu 
    1055                 1060                 1065             


Gln Gln  Asn Arg Asn Asn Arg  Asp Lys Thr Phe Thr  Val Gln Thr 
    1070                 1075                 1080             


Thr Trp  Ser Ser Met Lys Leu  Ser Met Met Ile Gln  Glu Ala Asn 
    1085                 1090                 1095             


Ala Ile  Ser Ser Lys Leu Lys  Thr Tyr Tyr Val Phe  Gly Arg His 
    1100                 1105                 1110             


Asp Ile  Ser Asp Lys Ser Ser  Ser Asp Thr Ser Ile  Arg Val Arg 
    1115                 1120                 1125             


Asn Leu  Lys Leu Gly Ile Ser  Thr Phe Trp Ser Leu  Glu Lys Phe 
    1130                 1135                 1140             


Glu Ser  Lys Leu Ala Ala Met  Lys Glu Leu Tyr Glu  Ser Asn Gly 
    1145                 1150                 1155             


Ser Asn  Arg Gly Glu Asp Ala  Phe Cys Asp Pro Glu  Asp Glu Trp 
    1160                 1165                 1170             


Glu Pro  Asp Ile Thr Asp Ala  Pro Val Ser Ser Leu  Ser Arg Arg 
    1175                 1180                 1185             


Arg Ser  Arg Ser Leu Met Lys  Asn Arg Arg Ile Ser  Gly Cys Leu 
    1190                 1195                 1200             


His Asp  Ile Gln Val His Pro  Ile Lys Asn Leu His  Ser Ser His 
    1205                 1210                 1215             


Ser Ser  Gly Leu Met Asp Lys  Ser Ser Thr Ile Tyr  Ser Asn Ser 
    1220                 1225                 1230             


Ala Glu  Ser Phe Leu Pro Gly  Ile Cys Lys Glu Leu  Ile Gly Ser 
    1235                 1240                 1245             


Ser Leu  Asp Phe Phe Gly Gln  Ser Tyr Asp Glu Glu  Arg Thr Ile 
    1250                 1255                 1260             


Ala Asp  Ser Leu Ile Asn Ser  Phe Leu Lys Ile Tyr  Asn Gly Leu 
    1265                 1270                 1275             


Phe Ala  Ile Ser Lys Ala His  Glu Glu Gln Asp Glu  Glu Ser Gln 
    1280                 1285                 1290             


Asp Asn  Leu Phe Ser Ser Asp  Arg Ala Ile Gln Ser  Leu Thr Ile 
    1295                 1300                 1305             


Gln Thr  Ala Cys Ala Phe Glu  Gln Leu Val Val Leu  Met Lys His 
    1310                 1315                 1320             


Trp Leu  Ser Asp Leu Leu Pro  Cys Thr Asn Ile Ala  Arg Leu Glu 
    1325                 1330                 1335             


Asp Glu  Leu Arg Gln Glu Val  Lys Lys Leu Gly Gly  Tyr Leu Gln 
    1340                 1345                 1350             


Leu Phe  Leu Gln Gly Cys Cys  Leu Asp Ile Ser Ser  Met Ile Lys 
    1355                 1360                 1365             


Glu Ala  Gln Lys Asn Ala Ile  Gln Ile Val Gln Gln  Ala Val Lys 
    1370                 1375                 1380             


Tyr Val  Gly Gln Leu Ala Val  Leu Lys Gly Ser Lys  Leu His Phe 
    1385                 1390                 1395             


Leu Glu  Asn Gly Asn Asn Lys  Ala Ala Ser Val Gln  Glu Glu Phe 
    1400                 1405                 1410             


Met Asp  Ala Val Cys Asp Gly  Val Gly Leu Gly Met  Lys Ile Leu 
    1415                 1420                 1425             


Leu Asp  Ser Gly Leu Glu Lys  Ala Lys Glu Leu Gln  His Glu Leu 
    1430                 1435                 1440             


Phe Arg  Gln Cys Thr Lys Asn  Glu Val Thr Lys Glu  Met Lys Thr 
    1445                 1450                 1455             


Asn Ala  Met Gly Leu Ile Arg  Ser Leu Glu Asn Ile  Phe Ala Glu 
    1460                 1465                 1470             


Ser Lys  Ile Lys Ser Phe Arg  Arg Gln Val Gln Glu  Glu Asn Phe 
    1475                 1480                 1485             


Glu Tyr  Gln Asp Phe Lys Arg  Met Val Asn Arg Ala  Pro Glu Phe 
    1490                 1495                 1500             


Leu Lys  Leu Lys His Cys Leu  Glu Lys Ala Ile Glu  Ile Ile Ile 
    1505                 1510                 1515             


Ser Ala  Leu Lys Gly Cys His  Ser Asp Ile Asn Leu  Leu Gln Thr 
    1520                 1525                 1530             


Cys Val  Glu Ser Ile Arg Asn  Leu Ala Ser Asp Phe  Tyr Ser Asp 
    1535                 1540                 1545             


Phe Ser  Val Pro Ser Thr Ser  Val Gly Ser Tyr Glu  Ser Arg Val 
    1550                 1555                 1560             


Thr His  Ile Val His Gln Glu  Leu Glu Ser Leu Ala  Lys Ser Leu 
    1565                 1570                 1575             


Leu Phe  Cys Phe Glu Ser Glu  Glu Ser Pro Asp Leu  Leu Lys Pro 
    1580                 1585                 1590             


Trp Glu  Thr Tyr Asn Gln Asn  Thr Lys Glu Glu His  Gln Gln Ser 
    1595                 1600                 1605             


Lys Ser  Ser Gly Ile Asp Gly  Ser Lys Asn Lys Gly  Val Pro Lys 
    1610                 1615                 1620             


Arg Val  Tyr Glu Leu His Gly  Ser Ser Pro Ala Val  Ser Ser Glu 
    1625                 1630                 1635             


Glu Cys  Thr Pro Ser Arg Ile  Gln Trp Val 
    1640                 1645             


<210>  5871
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF15__Homo_sapiens__NP_064627

<400>  5871

Met Ala Pro Gly Cys Lys Thr Glu Leu Arg Ser Val Thr Asn Gly Gln 
1               5                   10                  15      


Ser Asn Gln Pro Ser Asn Glu Gly Asp Ala Ile Lys Val Phe Val Arg 
            20                  25                  30          


Ile Arg Pro Pro Ala Glu Arg Ser Gly Ser Ala Asp Gly Glu Gln Asn 
        35                  40                  45              


Leu Cys Leu Ser Val Leu Ser Ser Thr Ser Leu Arg Leu His Ser Asn 
    50                  55                  60                  


Pro Glu Pro Lys Thr Phe Thr Phe Asp His Val Ala Asp Val Asp Thr 
65                  70                  75                  80  


Thr Gln Glu Ser Val Phe Ala Thr Val Ala Lys Ser Ile Val Glu Ser 
                85                  90                  95      


Cys Met Ser Gly Tyr Asn Gly Thr Ile Phe Ala Tyr Gly Gln Thr Gly 
            100                 105                 110         


Ser Gly Lys Thr Phe Thr Met Met Gly Pro Ser Glu Ser Asp Asn Phe 
        115                 120                 125             


Ser His Asn Leu Arg Gly Val Ile Pro Arg Ser Phe Glu Tyr Leu Phe 
    130                 135                 140                 


Ser Leu Ile Asp Arg Glu Lys Glu Lys Ala Gly Ala Gly Lys Ser Phe 
145                 150                 155                 160 


Leu Cys Lys Cys Ser Phe Ile Glu Ile Tyr Asn Glu Gln Ile Tyr Asp 
                165                 170                 175     


Leu Leu Asp Ser Ala Ser Ala Gly Leu Tyr Leu Arg Glu His Ile Lys 
            180                 185                 190         


Lys Gly Val Phe Val Val Gly Ala Val Glu Gln Val Val Thr Ser Ala 
        195                 200                 205             


Ala Glu Ala Tyr Gln Val Leu Ser Gly Gly Trp Arg Asn Arg Arg Val 
    210                 215                 220                 


Ala Ser Thr Ser Met Asn Arg Glu Ser Ser Arg Ser His Ala Val Phe 
225                 230                 235                 240 


Thr Ile Thr Ile Glu Ser Met Glu Lys Ser Asn Glu Ile Val Asn Ile 
                245                 250                 255     


Arg Thr Ser Leu Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln 
            260                 265                 270         


Lys Asp Thr His Ala Glu Gly Met Arg Leu Lys Glu Ala Gly Asn Ile 
        275                 280                 285             


Asn Arg Ser Leu Ser Cys Leu Gly Gln Val Ile Thr Ala Leu Val Asp 
    290                 295                 300                 


Val Gly Asn Gly Lys Gln Arg His Val Cys Tyr Arg Asp Ser Lys Leu 
305                 310                 315                 320 


Thr Phe Leu Leu Arg Asp Ser Leu Gly Gly Asn Ala Lys Thr Ala Ile 
                325                 330                 335     


Ile Ala Asn Val His Pro Gly Ser Arg Cys Phe Gly Glu Thr Leu Ser 
            340                 345                 350         


Thr Leu Asn Phe Ala Gln Arg Ala Lys Leu Ile Lys Asn Lys Ala Val 
        355                 360                 365             


Val Asn Glu Asp Thr Gln Gly Asn Val Ser Gln Leu Gln Ala Glu Val 
    370                 375                 380                 


Lys Arg Leu Lys Glu Gln Leu Ala Glu Leu Ala Ser Gly Gln Thr Pro 
385                 390                 395                 400 


Pro Glu Ser Phe Leu Thr Arg Asp Lys Lys Lys Thr Asn Tyr Met Glu 
                405                 410                 415     


Tyr Phe Gln Glu Ala Met Leu Phe Phe Lys Lys Ser Glu Gln Glu Lys 
            420                 425                 430         


Lys Ser Leu Ile Glu Lys Val Thr Gln Leu Glu Asp Leu Thr Leu Lys 
        435                 440                 445             


Lys Glu Lys Phe Ile Gln Ser Asn Lys Met Ile Val Lys Phe Arg Glu 
    450                 455                 460                 


Asp Gln Ile Ile Arg Leu Glu Lys Leu His Lys Glu Ser Arg Gly Gly 
465                 470                 475                 480 


Phe Leu Pro Glu Glu Gln Asp Arg Leu Leu Ser Glu Leu Arg Asn Glu 
                485                 490                 495     


Ile Gln Thr Leu Arg Glu Gln Ile Glu His His Pro Arg Val Ala Lys 
            500                 505                 510         


Tyr Ala Met Glu Asn His Ser Leu Arg Glu Glu Asn Arg Arg Leu Arg 
        515                 520                 525             


Leu Leu Glu Pro Val Lys Arg Ala Gln Glu Met Asp Ala Gln Thr Ile 
    530                 535                 540                 


Ala Lys Leu Glu Lys Ala Phe Ser Glu Ile Ser Gly Met Glu Lys Ser 
545                 550                 555                 560 


Asp Lys Asn Gln Gln Gly Phe Ser Pro Lys Ala Gln Lys Glu Pro Cys 
                565                 570                 575     


Leu Phe Ala Asn Thr Glu Lys Leu Lys Ala Gln Leu Leu Gln Ile Gln 
            580                 585                 590         


Thr Glu Leu Asn Asn Ser Lys Gln Glu Tyr Glu Glu Phe Lys Glu Leu 
        595                 600                 605             


Thr Arg Lys Arg Gln Leu Glu Leu Glu Ser Glu Leu Gln Ser Leu Gln 
    610                 615                 620                 


Lys Ala Asn Leu Asn Leu Glu Asn Leu Leu Glu Ala Thr Lys Ala Cys 
625                 630                 635                 640 


Lys Arg Gln Glu Val Ser Gln Leu Asn Lys Ile His Ala Glu Thr Leu 
                645                 650                 655     


Lys Ile Ile Thr Thr Pro Thr Lys Ala Tyr Gln Leu His Ser Arg Pro 
            660                 665                 670         


Val Pro Lys Leu Ser Pro Glu Met Gly Ser Phe Gly Ser Leu Tyr Thr 
        675                 680                 685             


Gln Asn Ser Ser Ile Leu Asp Asn Asp Ile Leu Asn Glu Pro Val Pro 
    690                 695                 700                 


Pro Glu Met Asn Glu Gln Ala Phe Glu Ala Ile Ser Glu Glu Leu Arg 
705                 710                 715                 720 


Thr Val Gln Glu Gln Met Ser Ala Leu Gln Ala Lys Leu Asp Glu Glu 
                725                 730                 735     


Glu His Lys Asn Leu Lys Leu Gln Gln His Val Asp Lys Leu Glu His 
            740                 745                 750         


His Ser Thr Gln Met Gln Glu Leu Phe Ser Ser Glu Arg Ile Asp Trp 
        755                 760                 765             


Thr Lys Gln Gln Glu Glu Leu Leu Ser Gln Leu Asn Val Leu Glu Lys 
    770                 775                 780                 


Gln Leu Gln Glu Thr Gln Thr Lys Asn Asp Phe Leu Lys Ser Glu Val 
785                 790                 795                 800 


His Asp Leu Arg Val Val Leu His Ser Ala Asp Lys Glu Leu Ser Ser 
                805                 810                 815     


Val Lys Leu Glu Tyr Ser Ser Phe Lys Thr Asn Gln Glu Lys Glu Phe 
            820                 825                 830         


Asn Lys Leu Ser Glu Arg His Met His Val Gln Leu Gln Leu Asp Asn 
        835                 840                 845             


Leu Arg Leu Glu Asn Glu Lys Leu Leu Glu Ser Lys Ala Cys Leu Gln 
    850                 855                 860                 


Asp Ser Tyr Asp Asn Leu Gln Glu Ile Met Lys Phe Glu Ile Asp Gln 
865                 870                 875                 880 


Leu Ser Arg Asn Leu Gln Asn Phe Lys Lys Glu Asn Glu Thr Leu Lys 
                885                 890                 895     


Ser Asp Leu Asn Asn Leu Met Glu Leu Leu Glu Ala Glu Lys Glu Arg 
            900                 905                 910         


Asn Asn Lys Leu Ser Leu Gln Phe Glu Glu Asp Lys Glu Asn Ser Ser 
        915                 920                 925             


Lys Glu Ile Leu Lys Val Leu Glu Ala Val Arg Gln Glu Lys Gln Lys 
    930                 935                 940                 


Glu Thr Ala Lys Cys Glu Gln Gln Met Ala Lys Val Gln Lys Leu Glu 
945                 950                 955                 960 


Glu Ser Leu Leu Ala Thr Glu Lys Val Ile Ser Ser Leu Glu Lys Ser 
                965                 970                 975     


Arg Asp Ser Asp Lys Lys Val Val Ala Asp Leu Met Asn Gln Ile Gln 
            980                 985                 990         


Glu Leu Arg Thr Ser Val Cys Glu  Lys Thr Glu Thr Ile  Asp Thr Leu 
        995                 1000                 1005             


Lys Gln  Glu Leu Lys Asp Ile  Asn Cys Lys Tyr Asn  Ser Ala Leu 
    1010                 1015                 1020             


Val Asp  Arg Glu Glu Ser Arg  Val Leu Ile Lys Lys  Gln Glu Val 
    1025                 1030                 1035             


Asp Ile  Leu Asp Leu Lys Glu  Thr Leu Arg Leu Arg  Ile Leu Ser 
    1040                 1045                 1050             


Glu Asp  Ile Glu Arg Asp Met  Leu Cys Glu Asp Leu  Ala His Ala 
    1055                 1060                 1065             


Thr Glu  Gln Leu Asn Met Leu  Thr Glu Ala Ser Lys  Lys His Ser 
    1070                 1075                 1080             


Gly Leu  Leu Gln Ser Ala Gln  Glu Glu Leu Thr Lys  Lys Glu Ala 
    1085                 1090                 1095             


Leu Ile  Gln Glu Leu Gln His  Lys Leu Asn Gln Lys  Lys Glu Glu 
    1100                 1105                 1110             


Val Glu  Gln Lys Lys Asn Glu  Tyr Asn Phe Lys Met  Arg Gln Leu 
    1115                 1120                 1125             


Glu His  Val Met Asp Ser Ala  Ala Glu Asp Pro Gln  Ser Pro Lys 
    1130                 1135                 1140             


Thr Pro  Pro His Phe Gln Thr  His Leu Ala Lys Leu  Leu Glu Thr 
    1145                 1150                 1155             


Gln Glu  Gln Glu Ile Glu Asp  Gly Arg Ala Ser Lys  Thr Ser Leu 
    1160                 1165                 1170             


Glu His  Leu Val Thr Lys Leu  Asn Glu Asp Arg Glu  Val Lys Asn 
    1175                 1180                 1185             


Ala Glu  Ile Leu Arg Met Lys  Glu Gln Leu Arg Glu  Met Glu Asn 
    1190                 1195                 1200             


Leu Arg  Leu Glu Ser Gln Gln  Leu Ile Glu Lys Asn  Trp Leu Leu 
    1205                 1210                 1215             


Gln Gly  Gln Leu Asp Asp Ile  Lys Arg Gln Lys Glu  Asn Ser Asp 
    1220                 1225                 1230             


Gln Asn  His Pro Asp Asn Gln  Gln Leu Lys Asn Glu  Gln Glu Glu 
    1235                 1240                 1245             


Ser Ile  Lys Glu Arg Leu Ala  Lys Ser Lys Ile Val  Glu Glu Met 
    1250                 1255                 1260             


Leu Lys  Met Lys Ala Asp Leu  Glu Glu Val Gln Ser  Ala Leu Tyr 
    1265                 1270                 1275             


Asn Lys  Glu Met Glu Cys Leu  Arg Met Thr Asp Glu  Val Glu Arg 
    1280                 1285                 1290             


Thr Gln  Thr Leu Glu Ser Lys  Ala Phe Gln Glu Lys  Glu Gln Leu 
    1295                 1300                 1305             


Arg Ser  Lys Leu Glu Glu Met  Tyr Glu Glu Arg Glu  Arg Thr Ser 
    1310                 1315                 1320             


Gln Glu  Met Glu Met Leu Arg  Lys Gln Val Glu Cys  Leu Ala Glu 
    1325                 1330                 1335             


Glu Asn  Gly Lys Leu Val Gly  His Gln Asn Leu His  Gln Lys Ile 
    1340                 1345                 1350             


Gln Tyr  Val Val Arg Leu Lys  Lys Glu Asn Val Arg  Leu Ala Glu 
    1355                 1360                 1365             


Glu Thr  Glu Lys Leu Arg Ala  Glu Asn Val Phe Leu  Lys Glu Lys 
    1370                 1375                 1380             


Lys Arg  Ser Glu Ser 
    1385             


<210>  5872
<211>  1392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF16B__Homo_sapiens__NP_001186795

<400>  5872

Met Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Met Asn Arg Arg 
1               5                   10                  15      


Glu Lys Asp Leu Glu Ala Lys Phe Ile Ile Gln Met Glu Lys Ser Lys 
            20                  25                  30          


Thr Thr Ile Thr Asn Leu Lys Ile Pro Glu Gly Gly Thr Gly Asp Ser 
        35                  40                  45              


Gly Arg Glu Arg Thr Lys Thr Phe Thr Tyr Asp Phe Ser Phe Tyr Ser 
    50                  55                  60                  


Ala Asp Thr Lys Ser Pro Asp Tyr Val Ser Gln Glu Met Val Phe Lys 
65                  70                  75                  80  


Thr Leu Gly Thr Asp Val Val Lys Ser Ala Phe Glu Gly Tyr Asn Ala 
                85                  90                  95      


Cys Val Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Tyr Thr Met 
            100                 105                 110         


Met Gly Asn Ser Gly Asp Ser Gly Leu Ile Pro Arg Ile Cys Glu Gly 
        115                 120                 125             


Leu Phe Ser Arg Ile Asn Glu Thr Thr Arg Trp Asp Glu Ala Ser Phe 
    130                 135                 140                 


Arg Thr Glu Val Ser Tyr Leu Glu Ile Tyr Asn Glu Arg Val Arg Asp 
145                 150                 155                 160 


Leu Leu Arg Arg Lys Ser Ser Lys Thr Phe Asn Leu Arg Val Arg Glu 
                165                 170                 175     


His Pro Lys Glu Gly Pro Tyr Val Glu Asp Leu Ser Lys His Leu Val 
            180                 185                 190         


Gln Asn Tyr Gly Asp Val Glu Glu Leu Met Asp Ala Gly Asn Ile Asn 
        195                 200                 205             


Arg Thr Thr Ala Ala Thr Gly Met Asn Asp Val Ser Ser Arg Ser His 
    210                 215                 220                 


Ala Ile Phe Thr Ile Lys Phe Thr Gln Ala Lys Phe Asp Ser Glu Met 
225                 230                 235                 240 


Pro Cys Glu Thr Val Ser Lys Ile His Leu Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Ala Asp Ala Thr Gly Ala Thr Gly Val Arg Leu Lys Glu Gly 
            260                 265                 270         


Gly Asn Ile Asn Lys Ser Leu Val Thr Leu Gly Asn Val Ile Ser Ala 
        275                 280                 285             


Leu Ala Asp Leu Ser Gln Asp Ala Ala Asn Thr Leu Ala Lys Lys Lys 
    290                 295                 300                 


Gln Val Phe Val Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Lys 
305                 310                 315                 320 


Asp Ser Leu Gly Gly Asn Ser Lys Thr Ile Met Ile Ala Thr Ile Ser 
                325                 330                 335     


Pro Ala Asp Val Asn Tyr Gly Glu Thr Leu Ser Thr Leu Arg Tyr Ala 
            340                 345                 350         


Asn Arg Ala Lys Asn Ile Ile Asn Lys Pro Thr Ile Asn Glu Asp Ala 
        355                 360                 365             


Asn Val Lys Leu Ile Arg Glu Leu Arg Ala Glu Ile Ala Arg Leu Lys 
    370                 375                 380                 


Thr Leu Leu Ala Gln Gly Asn Gln Ile Ala Leu Leu Asp Ser Pro Thr 
385                 390                 395                 400 


Ala Leu Ser Met Glu Glu Lys Leu Gln Gln Asn Glu Ala Arg Val Gln 
                405                 410                 415     


Glu Leu Thr Lys Glu Trp Thr Asn Lys Trp Asn Glu Thr Gln Asn Ile 
            420                 425                 430         


Leu Lys Glu Gln Thr Leu Ala Leu Arg Lys Glu Gly Ile Gly Val Val 
        435                 440                 445             


Leu Asp Ser Glu Leu Pro His Leu Ile Gly Ile Asp Asp Asp Leu Leu 
    450                 455                 460                 


Ser Thr Gly Ile Ile Leu Tyr His Leu Lys Glu Gly Gln Thr Tyr Val 
465                 470                 475                 480 


Gly Arg Asp Asp Ala Ser Thr Glu Gln Asp Ile Val Leu His Gly Leu 
                485                 490                 495     


Asp Leu Glu Ser Glu His Cys Ile Phe Glu Asn Ile Gly Gly Thr Val 
            500                 505                 510         


Thr Leu Ile Pro Leu Ser Gly Ser Gln Cys Ser Val Asn Gly Val Gln 
        515                 520                 525             


Ile Val Glu Ala Thr His Leu Asn Gln Gly Ala Val Ile Leu Leu Gly 
    530                 535                 540                 


Arg Thr Asn Met Phe Arg Phe Asn His Pro Lys Glu Ala Ala Lys Leu 
545                 550                 555                 560 


Arg Glu Lys Arg Lys Ser Gly Leu Leu Ser Ser Phe Ser Leu Ser Met 
                565                 570                 575     


Thr Asp Leu Ser Lys Ser Arg Glu Asn Leu Ser Ala Val Met Leu Tyr 
            580                 585                 590         


Asn Pro Gly Leu Glu Phe Glu Arg Gln Gln Arg Glu Glu Leu Glu Lys 
        595                 600                 605             


Leu Glu Ser Lys Arg Lys Leu Ile Glu Glu Met Glu Glu Lys Gln Lys 
    610                 615                 620                 


Ser Asp Lys Ala Glu Leu Glu Arg Met Gln Gln Glu Val Glu Thr Gln 
625                 630                 635                 640 


Arg Lys Glu Thr Glu Ile Val Gln Leu Gln Ile Arg Lys Gln Glu Glu 
                645                 650                 655     


Ser Leu Lys Arg Arg Ser Phe His Ile Glu Asn Lys Leu Lys Asp Leu 
            660                 665                 670         


Leu Ala Glu Lys Glu Lys Phe Glu Glu Glu Arg Leu Arg Glu Gln Gln 
        675                 680                 685             


Glu Ile Glu Leu Gln Lys Lys Arg Gln Glu Glu Glu Thr Phe Leu Arg 
    690                 695                 700                 


Val Gln Glu Glu Leu Gln Arg Leu Lys Glu Leu Asn Asn Asn Glu Lys 
705                 710                 715                 720 


Ala Glu Lys Phe Gln Ile Phe Gln Glu Leu Asp Gln Leu Gln Lys Glu 
                725                 730                 735     


Lys Asp Glu Gln Tyr Ala Lys Leu Glu Leu Glu Lys Lys Arg Leu Glu 
            740                 745                 750         


Glu Gln Glu Lys Glu Gln Val Met Leu Val Ala His Leu Glu Glu Gln 
        755                 760                 765             


Leu Arg Glu Lys Gln Glu Met Ile Gln Leu Leu Arg Arg Gly Glu Val 
    770                 775                 780                 


Gln Trp Val Glu Glu Glu Lys Arg Asp Leu Glu Gly Ile Arg Glu Ser 
785                 790                 795                 800 


Leu Leu Arg Val Lys Glu Ala Arg Ala Gly Gly Asp Glu Asp Gly Glu 
                805                 810                 815     


Glu Leu Glu Lys Ala Gln Leu Arg Phe Phe Glu Phe Lys Arg Arg Gln 
            820                 825                 830         


Leu Val Lys Leu Val Asn Leu Glu Lys Asp Leu Val Gln Gln Lys Asp 
        835                 840                 845             


Ile Leu Lys Lys Glu Val Gln Glu Glu Gln Glu Ile Leu Glu Cys Leu 
    850                 855                 860                 


Lys Cys Glu His Asp Lys Glu Ser Arg Leu Leu Glu Lys His Asp Glu 
865                 870                 875                 880 


Ser Val Thr Asp Val Thr Glu Val Pro Gln Asp Phe Glu Lys Ile Lys 
                885                 890                 895     


Pro Val Glu Tyr Arg Leu Gln Tyr Lys Glu Arg Gln Leu Gln Tyr Leu 
            900                 905                 910         


Leu Gln Asn His Leu Pro Thr Leu Leu Glu Glu Lys Gln Arg Ala Phe 
        915                 920                 925             


Glu Ile Leu Asp Arg Gly Pro Leu Ser Leu Asp Asn Thr Leu Tyr Gln 
    930                 935                 940                 


Val Glu Lys Glu Met Glu Glu Lys Glu Glu Gln Leu Ala Gln Tyr Gln 
945                 950                 955                 960 


Ala Asn Ala Asn Gln Leu Gln Lys Leu Gln Ala Thr Phe Glu Phe Thr 
                965                 970                 975     


Ala Asn Ile Ala Arg Gln Glu Glu Lys Val Arg Lys Lys Glu Lys Glu 
            980                 985                 990         


Ile Leu Glu Ser Arg Glu Lys Gln  Gln Arg Glu Ala Leu  Glu Arg Ala 
        995                 1000                 1005             


Leu Ala  Arg Leu Glu Arg Arg  His Ser Ala Leu Gln  Arg His Ser 
    1010                 1015                 1020             


Thr Leu  Gly Met Glu Ile Glu  Glu Gln Arg Gln Lys  Leu Ala Ser 
    1025                 1030                 1035             


Leu Asn  Ser Gly Ser Arg Glu  Gln Ser Gly Leu Gln  Ala Ser Leu 
    1040                 1045                 1050             


Glu Ala  Glu Gln Glu Ala Leu  Glu Lys Asp Gln Glu  Arg Leu Glu 
    1055                 1060                 1065             


Tyr Glu  Ile Gln Gln Leu Lys  Gln Lys Ile Tyr Glu  Val Asp Gly 
    1070                 1075                 1080             


Val Gln  Lys Asp His His Gly  Thr Leu Glu Gly Lys  Val Ala Ser 
    1085                 1090                 1095             


Ser Ser  Leu Pro Val Ser Ala  Glu Lys Ser His Leu  Val Pro Leu 
    1100                 1105                 1110             


Met Asp  Ala Arg Ile Asn Ala  Tyr Ile Glu Glu Glu  Val Gln Arg 
    1115                 1120                 1125             


Arg Leu  Gln Asp Leu His Arg  Val Ile Ser Glu Gly  Cys Ser Thr 
    1130                 1135                 1140             


Ser Ala  Asp Thr Met Lys Asp  Asn Glu Lys Leu His  Asn Gly Thr 
    1145                 1150                 1155             


Ile Gln  Arg Lys Leu Lys Tyr  Glu Leu Cys Arg Asp  Leu Leu Cys 
    1160                 1165                 1170             


Val Leu  Met Pro Glu Pro Asp  Ala Ala Ala Cys Ala  Asn His Pro 
    1175                 1180                 1185             


Leu Leu  Gln Gln Asp Leu Val  Gln Leu Ser Leu Asp  Trp Lys Thr 
    1190                 1195                 1200             


Glu Ile  Pro Asp Leu Val Leu  Pro Asn Gly Val Gln  Val Ser Ser 
    1205                 1210                 1215             


Lys Phe  Gln Thr Thr Leu Val  Asp Met Ile Tyr Phe  Leu His Gly 
    1220                 1225                 1230             


Asn Met  Glu Val Asn Val Pro  Ser Leu Ala Glu Val  Gln Leu Leu 
    1235                 1240                 1245             


Leu Tyr  Thr Thr Val Lys Val  Met Gly Asp Ser Gly  His Asp Gln 
    1250                 1255                 1260             


Cys Gln  Ser Leu Val Leu Leu  Asn Thr His Ile Ala  Leu Val Lys 
    1265                 1270                 1275             


Glu Asp  Cys Val Phe Tyr Pro  Arg Ile Arg Ser Arg  Asn Ile Pro 
    1280                 1285                 1290             


Pro Pro  Gly Ala Gln Phe Asp  Val Ile Lys Cys His  Ala Leu Ser 
    1295                 1300                 1305             


Glu Phe  Arg Cys Val Val Val  Pro Glu Lys Lys Asn  Val Ser Thr 
    1310                 1315                 1320             


Val Glu  Leu Val Phe Leu Gln  Lys Leu Lys Pro Ser  Val Gly Ser 
    1325                 1330                 1335             


Arg Asn  Ser Pro Pro Glu His  Leu Gln Glu Ala Pro  Asn Val Gln 
    1340                 1345                 1350             


Leu Phe  Thr Thr Pro Leu Tyr  Leu Gln Gly Ser Gln  Asn Val Ala 
    1355                 1360                 1365             


Pro Glu  Val Trp Lys Leu Thr  Phe Asn Ser Gln Asp  Glu Ala Leu 
    1370                 1375                 1380             


Trp Leu  Ile Ser His Leu Thr  Arg Leu 
    1385                 1390         


<210>  5873
<211>  1038
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF17__Homo_sapiens__XP_011540143

<400>  5873

Met Ala Ser Glu Ala Val Lys Val Val Val Arg Cys Arg Pro Met Asn 
1               5                   10                  15      


Gln Arg Glu Arg Glu Leu Arg Cys Gln Pro Val Val Thr Val Asp Cys 
            20                  25                  30          


Ala Arg Ala Gln Cys Cys Ile Gln Asn Pro Gly Ala Ala Asp Glu Pro 
        35                  40                  45              


Pro Lys Gln Phe Thr Phe Asp Gly Ala Tyr His Val Asp His Val Thr 
    50                  55                  60                  


Glu Gln Ile Tyr Asn Glu Ile Ala Tyr Pro Leu Val Glu Gly Val Thr 
65                  70                  75                  80  


Glu Gly Tyr Asn Gly Thr Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly 
                85                  90                  95      


Lys Ser Phe Thr Met Gln Gly Leu Pro Asp Pro Pro Ser Gln Arg Gly 
            100                 105                 110         


Ile Ile Pro Arg Ala Phe Glu His Val Phe Glu Ser Val Gln Cys Ala 
        115                 120                 125             


Glu Asn Thr Lys Phe Leu Val Arg Ala Ser Tyr Leu Glu Ile Tyr Asn 
    130                 135                 140                 


Glu Asp Val Arg Asp Leu Leu Gly Ala Asp Thr Lys Gln Lys Leu Glu 
145                 150                 155                 160 


Leu Lys Glu His Pro Glu Lys Gly Val Tyr Val Lys Gly Leu Ser Met 
                165                 170                 175     


His Thr Val His Ser Val Ala Gln Cys Glu His Ile Met Glu Thr Gly 
            180                 185                 190         


Trp Lys Asn Arg Ser Val Gly Tyr Thr Leu Met Asn Lys Asp Ser Ser 
        195                 200                 205             


Arg Ser His Ser Ile Phe Thr Ile Ser Ile Glu Met Ser Ala Val Asp 
    210                 215                 220                 


Glu Arg Gly Lys Asp His Leu Arg Ala Gly Lys Leu Asn Leu Val Asp 
225                 230                 235                 240 


Leu Ala Gly Ser Glu Arg Gln Ser Lys Thr Gly Ala Thr Gly Glu Arg 
                245                 250                 255     


Leu Lys Glu Ala Thr Lys Ile Asn Leu Ser Leu Ser Ala Leu Gly Asn 
            260                 265                 270         


Val Ile Ser Ala Leu Val Asp Gly Arg Cys Lys His Val Pro Tyr Arg 
        275                 280                 285             


Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Thr 
    290                 295                 300                 


Lys Thr Leu Met Val Ala Cys Leu Ser Pro Ala Asp Asn Asn Tyr Asp 
305                 310                 315                 320 


Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asn Arg Ala Lys Asn Ile Arg 
                325                 330                 335     


Asn Lys Pro Arg Ile Asn Glu Asp Pro Lys Asp Ala Leu Leu Arg Glu 
            340                 345                 350         


Tyr Gln Glu Glu Ile Lys Lys Leu Lys Ala Ile Leu Thr Gln Gln Met 
        355                 360                 365             


Ser Pro Ser Ser Leu Ser Ala Leu Leu Ser Arg Gln Val Pro Pro Asp 
    370                 375                 380                 


Pro Val Gln Val Glu Glu Lys Leu Leu Pro Gln Pro Val Ile Gln His 
385                 390                 395                 400 


Asp Val Glu Ala Glu Lys Gln Leu Ile Arg Glu Glu Tyr Glu Glu Arg 
                405                 410                 415     


Leu Ala Arg Leu Lys Ala Asp Tyr Lys Ala Glu Gln Glu Ser Arg Ala 
            420                 425                 430         


Arg Leu Glu Glu Asp Ile Thr Ala Met Arg Asn Ser Tyr Asp Val Arg 
        435                 440                 445             


Leu Ser Thr Leu Glu Glu Asn Leu Arg Lys Glu Thr Glu Ala Val Leu 
    450                 455                 460                 


Gln Val Gly Val Leu Tyr Lys Ala Glu Val Met Ser Arg Ala Glu Phe 
465                 470                 475                 480 


Ala Ser Ser Ala Glu Tyr Pro Pro Ala Phe Gln Tyr Glu Thr Val Val 
                485                 490                 495     


Lys Pro Lys Val Phe Ser Thr Thr Asp Thr Leu Pro Ser Asp Asp Val 
            500                 505                 510         


Ser Lys Thr Gln Val Ser Ser Arg Phe Ala Glu Leu Pro Lys Val Glu 
        515                 520                 525             


Pro Ser Lys Ser Glu Ile Ser Leu Gly Ser Ser Glu Ser Ser Ser Leu 
    530                 535                 540                 


Glu Glu Thr Ser Val Ser Glu Ala Phe Pro Gly Pro Glu Glu Pro Ser 
545                 550                 555                 560 


Asn Val Glu Val Ser Met Pro Thr Glu Glu Ser Arg Ser Arg Tyr Phe 
                565                 570                 575     


Leu Asp Glu Cys Leu Gly Gln Glu Ala Ala Gly His Leu Leu Gly Glu 
            580                 585                 590         


Gln Asn Tyr Leu Pro Gln Glu Glu Pro Gln Glu Val Pro Leu Gln Gly 
        595                 600                 605             


Leu Leu Gly Leu Gln Asp Pro Phe Ala Glu Val Glu Ala Lys Leu Ala 
    610                 615                 620                 


Arg Leu Ser Ser Thr Val Ala Arg Thr Asp Ala Pro Gln Ala Asp Val 
625                 630                 635                 640 


Pro Lys Val Pro Val Gln Val Pro Ala Pro Thr Asp Leu Leu Glu Pro 
                645                 650                 655     


Ser Asp Ala Arg Pro Glu Ala Glu Ala Ala Asp Asp Phe Pro Pro Arg 
            660                 665                 670         


Pro Glu Val Asp Leu Ala Ser Glu Val Ala Leu Glu Val Val Arg Thr 
        675                 680                 685             


Ala Glu Pro Gly Val Trp Leu Glu Ala Gln Ala Pro Val Ala Leu Val 
    690                 695                 700                 


Ala Gln Pro Glu Pro Leu Pro Ala Thr Ala Gly Val Lys Arg Glu Ser 
705                 710                 715                 720 


Val Gly Met Glu Val Ala Val Leu Thr Asp Asp Pro Leu Pro Val Val 
                725                 730                 735     


Asp Gln Gln Gln Val Leu Ala Arg Leu Gln Leu Leu Glu Gln Gln Val 
            740                 745                 750         


Val Gly Gly Glu Gln Ala Lys Asn Lys Asp Leu Lys Glu Lys His Lys 
        755                 760                 765             


Arg Arg Lys Arg Tyr Ala Asp Glu Arg Arg Lys Gln Leu Val Ala Ala 
    770                 775                 780                 


Leu Gln Asn Ser Asp Glu Asp Ser Gly Asp Trp Val Leu Leu Asn Val 
785                 790                 795                 800 


Tyr Asp Ser Ile Gln Glu Glu Val Arg Ala Lys Ser Lys Leu Leu Glu 
                805                 810                 815     


Lys Met Gln Arg Lys Leu Arg Ala Ala Glu Val Glu Ile Lys Asp Leu 
            820                 825                 830         


Gln Ser Glu Phe Gln Leu Glu Lys Ile Asp Tyr Leu Ala Thr Ile Arg 
        835                 840                 845             


Arg Gln Glu Arg Asp Ser Met Leu Leu Gln Gln Leu Leu Glu Gln Val 
    850                 855                 860                 


Gln Pro Leu Ile Arg Arg Asp Cys Asn Tyr Ser Asn Leu Glu Lys Ile 
865                 870                 875                 880 


Leu Arg Glu Ser Cys Trp Asp Glu Asp Asn Gly Phe Trp Lys Ile Pro 
                885                 890                 895     


His Pro Val Ile Thr Lys Thr Ser Leu Pro Gln Phe Gln Leu Gly His 
            900                 905                 910         


Arg Thr Asn Gln Pro Ala Lys Pro Leu Gln Gln Thr Met Ala Ser Arg 
        915                 920                 925             


Thr Trp Arg Thr Thr Ala Thr Gly Ser Cys Ser Val Gly Ala Thr Val 
    930                 935                 940                 


Lys Thr Leu Pro Ala Thr Thr Ser Asp Leu Ser Gly Pro Ala Arg Ser 
945                 950                 955                 960 


Ser Ala Gln Thr Pro Gly Arg Ala Ser His Ile Thr Thr Arg His Gln 
                965                 970                 975     


Ala Ser Ala Ala His Ser Ala Thr Thr Leu Pro Ser His Pro Pro Arg 
            980                 985                 990         


Pro Leu Lys Cys Pro Ser Pro Gly  Pro Ser Ala Ser Ser  Pro Ser Thr 
        995                 1000                 1005             


Ser Leu  Ser Pro Arg Pro Ser  Leu Pro Ser Pro Leu  Ala Ser Gly 
    1010                 1015                 1020             


Leu Trp  Leu Gly Pro Arg Gly  Arg Trp Lys Ser Cys  Cys Leu Trp 
    1025                 1030                 1035             


<210>  5874
<211>  898
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF18A__Homo_sapiens__NP_112494

<400>  5874

Met Ser Val Thr Glu Glu Asp Leu Cys His His Met Lys Val Val Val 
1               5                   10                  15      


Arg Val Arg Pro Glu Asn Thr Lys Glu Lys Ala Ala Gly Phe His Lys 
            20                  25                  30          


Val Val His Val Val Asp Lys His Ile Leu Val Phe Asp Pro Lys Gln 
        35                  40                  45              


Glu Glu Val Ser Phe Phe His Gly Lys Lys Thr Thr Asn Gln Asn Val 
    50                  55                  60                  


Ile Lys Lys Gln Asn Lys Asp Leu Lys Phe Val Phe Asp Ala Val Phe 
65                  70                  75                  80  


Asp Glu Thr Ser Thr Gln Ser Glu Val Phe Glu His Thr Thr Lys Pro 
                85                  90                  95      


Ile Leu Arg Ser Phe Leu Asn Gly Tyr Asn Cys Thr Val Leu Ala Tyr 
            100                 105                 110         


Gly Ala Thr Gly Ala Gly Lys Thr His Thr Met Leu Gly Ser Ala Asp 
        115                 120                 125             


Glu Pro Gly Val Met Tyr Leu Thr Met Leu His Leu Tyr Lys Cys Met 
    130                 135                 140                 


Asp Glu Ile Lys Glu Glu Lys Ile Cys Ser Thr Ala Val Ser Tyr Leu 
145                 150                 155                 160 


Glu Val Tyr Asn Glu Gln Ile Arg Asp Leu Leu Val Asn Ser Gly Pro 
                165                 170                 175     


Leu Ala Val Arg Glu Asp Thr Gln Lys Gly Val Val Val His Gly Leu 
            180                 185                 190         


Thr Leu His Gln Pro Lys Ser Ser Glu Glu Ile Leu His Leu Leu Asp 
        195                 200                 205             


Asn Gly Asn Lys Asn Arg Thr Gln His Pro Thr Asp Met Asn Ala Thr 
    210                 215                 220                 


Ser Ser Arg Ser His Ala Val Phe Gln Ile Tyr Leu Arg Gln Gln Asp 
225                 230                 235                 240 


Lys Thr Ala Ser Ile Asn Gln Asn Val Arg Ile Ala Lys Met Ser Leu 
                245                 250                 255     


Ile Asp Leu Ala Gly Ser Glu Arg Ala Ser Thr Ser Gly Ala Lys Gly 
            260                 265                 270         


Thr Arg Phe Val Glu Gly Thr Asn Ile Asn Arg Ser Leu Leu Ala Leu 
        275                 280                 285             


Gly Asn Val Ile Asn Ala Leu Ala Asp Ser Lys Arg Lys Asn Gln His 
    290                 295                 300                 


Ile Pro Tyr Arg Asn Ser Lys Leu Thr Arg Leu Leu Lys Asp Ser Leu 
305                 310                 315                 320 


Gly Gly Asn Cys Gln Thr Ile Met Ile Ala Ala Val Ser Pro Ser Ser 
                325                 330                 335     


Val Phe Tyr Asp Asp Thr Tyr Asn Thr Leu Lys Tyr Ala Asn Arg Ala 
            340                 345                 350         


Lys Asp Ile Lys Ser Ser Leu Lys Ser Asn Val Leu Asn Val Asn Asn 
        355                 360                 365             


His Ile Thr Gln Tyr Val Lys Ile Cys Asn Glu Gln Lys Ala Glu Ile 
    370                 375                 380                 


Leu Leu Leu Lys Glu Lys Leu Lys Ala Tyr Glu Glu Gln Lys Ala Phe 
385                 390                 395                 400 


Thr Asn Glu Asn Asp Gln Ala Lys Leu Met Ile Ser Asn Pro Gln Glu 
                405                 410                 415     


Lys Glu Ile Glu Arg Phe Gln Glu Ile Leu Asn Cys Leu Phe Gln Asn 
            420                 425                 430         


Arg Glu Glu Ile Arg Gln Glu Tyr Leu Lys Leu Glu Met Leu Leu Lys 
        435                 440                 445             


Glu Asn Glu Leu Lys Ser Phe Tyr Gln Gln Gln Cys His Lys Gln Ile 
    450                 455                 460                 


Glu Met Met Cys Ser Glu Asp Lys Val Glu Lys Ala Thr Gly Lys Arg 
465                 470                 475                 480 


Asp His Arg Leu Ala Met Leu Lys Thr Arg Arg Ser Tyr Leu Glu Lys 
                485                 490                 495     


Arg Arg Glu Glu Glu Leu Lys Gln Phe Asp Glu Asn Thr Asn Trp Leu 
            500                 505                 510         


His Arg Val Glu Lys Glu Met Gly Leu Leu Ser Gln Asn Gly His Ile 
        515                 520                 525             


Pro Lys Glu Leu Lys Lys Asp Leu His Cys His His Leu His Leu Gln 
    530                 535                 540                 


Asn Lys Asp Leu Lys Ala Gln Ile Arg His Met Met Asp Leu Ala Cys 
545                 550                 555                 560 


Leu Gln Glu Gln Gln His Arg Gln Thr Glu Ala Val Leu Asn Ala Leu 
                565                 570                 575     


Leu Pro Thr Leu Arg Lys Gln Tyr Cys Thr Leu Lys Glu Ala Gly Leu 
            580                 585                 590         


Ser Asn Ala Ala Phe Glu Ser Asp Phe Lys Glu Ile Glu His Leu Val 
        595                 600                 605             


Glu Arg Lys Lys Val Val Val Trp Ala Asp Gln Thr Ala Glu Gln Pro 
    610                 615                 620                 


Lys Gln Asn Asp Leu Pro Gly Ile Ser Val Leu Met Thr Phe Pro Gln 
625                 630                 635                 640 


Leu Gly Pro Val Gln Pro Ile Pro Cys Cys Ser Ser Ser Gly Gly Thr 
                645                 650                 655     


Asn Leu Val Lys Ile Pro Thr Glu Lys Arg Thr Arg Arg Lys Leu Met 
            660                 665                 670         


Pro Ser Pro Leu Lys Gly Gln His Thr Leu Lys Ser Pro Pro Ser Gln 
        675                 680                 685             


Ser Val Gln Leu Asn Asp Ser Leu Ser Lys Glu Leu Gln Pro Ile Val 
    690                 695                 700                 


Tyr Thr Pro Glu Asp Cys Arg Lys Ala Phe Gln Asn Pro Ser Thr Val 
705                 710                 715                 720 


Thr Leu Met Lys Pro Ser Ser Phe Thr Thr Ser Phe Gln Ala Ile Ser 
                725                 730                 735     


Ser Asn Ile Asn Ser Asp Asn Cys Leu Lys Met Leu Cys Glu Val Ala 
            740                 745                 750         


Ile Pro His Asn Arg Arg Lys Glu Cys Gly Gln Glu Asp Leu Asp Ser 
        755                 760                 765             


Thr Phe Thr Ile Cys Glu Asp Ile Lys Ser Ser Lys Cys Lys Leu Pro 
    770                 775                 780                 


Glu Gln Glu Ser Leu Pro Asn Asp Asn Lys Asp Ile Leu Gln Arg Leu 
785                 790                 795                 800 


Asp Pro Ser Ser Phe Ser Thr Lys His Ser Met Pro Val Pro Ser Met 
                805                 810                 815     


Val Pro Ser Tyr Met Ala Met Thr Thr Ala Ala Lys Arg Lys Arg Lys 
            820                 825                 830         


Leu Thr Ser Ser Thr Ser Asn Ser Ser Leu Thr Ala Asp Val Asn Ser 
        835                 840                 845             


Gly Phe Ala Lys Arg Val Arg Gln Asp Asn Ser Ser Glu Lys His Leu 
    850                 855                 860                 


Gln Glu Asn Lys Pro Thr Met Glu His Lys Arg Asn Ile Cys Lys Ile 
865                 870                 875                 880 


Asn Pro Ser Met Val Arg Lys Phe Gly Arg Asn Ile Ser Lys Gly Asn 
                885                 890                 895     


Leu Arg 
        


<210>  5875
<211>  1791
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF1A__Homo_sapiens__NP_001230937

<400>  5875

Met Ala Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn 
1               5                   10                  15      


Ser Arg Glu Met Ser Arg Asp Ser Lys Cys Ile Ile Gln Met Ser Gly 
            20                  25                  30          


Ser Thr Thr Thr Ile Val Asn Pro Lys Gln Pro Lys Glu Thr Pro Lys 
        35                  40                  45              


Ser Phe Ser Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp 
    50                  55                  60                  


Ile Asn Tyr Ala Ser Gln Lys Gln Val Tyr Arg Asp Ile Gly Glu Glu 
65                  70                  75                  80  


Met Leu Gln His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu 
            100                 105                 110         


Lys Asp Gln Gln Gly Ile Ile Pro Gln Leu Cys Glu Asp Leu Phe Ser 
        115                 120                 125             


Arg Ile Asn Asp Thr Thr Asn Asp Asn Met Ser Tyr Ser Val Glu Val 
    130                 135                 140                 


Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro 
145                 150                 155                 160 


Lys Asn Lys Gly Asn Leu Arg Val Arg Glu His Pro Leu Leu Gly Pro 
                165                 170                 175     


Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Asn Asp Ile 
            180                 185                 190         


Gln Asp Leu Met Asp Ser Gly Asn Lys Ala Arg Thr Val Ala Ala Thr 
        195                 200                 205             


Asn Met Asn Glu Thr Ser Ser Arg Ser His Ala Val Phe Asn Ile Ile 
    210                 215                 220                 


Phe Thr Gln Lys Arg His Asp Ala Glu Thr Asn Ile Thr Thr Glu Lys 
225                 230                 235                 240 


Val Ser Lys Ile Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Asp 
                245                 250                 255     


Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Asn Ile Asn 
            260                 265                 270         


Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Met 
        275                 280                 285             


Asp Ser Gly Pro Asn Lys Asn Lys Lys Lys Lys Lys Thr Asp Phe Ile 
    290                 295                 300                 


Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Arg Glu Asn Leu Gly 
305                 310                 315                 320 


Gly Asn Ser Arg Thr Ala Met Val Ala Ala Leu Ser Pro Ala Asp Ile 
                325                 330                 335     


Asn Tyr Asp Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys 
            340                 345                 350         


Gln Ile Arg Cys Asn Ala Val Ile Asn Glu Asp Pro Asn Asn Lys Leu 
        355                 360                 365             


Ile Arg Glu Leu Lys Asp Glu Val Thr Arg Leu Arg Asp Leu Leu Tyr 
    370                 375                 380                 


Ala Gln Gly Leu Gly Asp Ile Thr Asp Thr Asn Thr Val Pro Gly Gly 
385                 390                 395                 400 


Pro Lys Leu Thr Asn Ala Leu Val Gly Met Ser Pro Ser Ser Ser Leu 
                405                 410                 415     


Ser Ala Leu Ser Ser Arg Ala Ala Ser Val Ser Ser Leu His Glu Arg 
            420                 425                 430         


Ile Leu Phe Ala Pro Gly Ser Glu Glu Ala Ile Glu Arg Leu Lys Glu 
        435                 440                 445             


Thr Glu Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys Leu 
    450                 455                 460                 


Arg Arg Thr Glu Ala Ile Arg Met Glu Arg Glu Ala Leu Leu Ala Glu 
465                 470                 475                 480 


Met Gly Val Ala Met Arg Glu Asp Gly Gly Thr Leu Gly Val Phe Ser 
                485                 490                 495     


Pro Lys Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu Met 
            500                 505                 510         


Ser Glu Cys Leu Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val Gly 
        515                 520                 525             


Arg Glu Asp Gly Glu Arg Arg Gln Asp Ile Val Leu Ser Gly His Phe 
    530                 535                 540                 


Ile Lys Glu Glu His Cys Val Phe Arg Ser Asp Ser Arg Gly Gly Ser 
545                 550                 555                 560 


Glu Ala Val Val Thr Leu Glu Pro Cys Glu Gly Ala Asp Thr Tyr Val 
                565                 570                 575     


Asn Gly Lys Lys Val Thr Glu Pro Ser Ile Leu Arg Ser Gly Asn Arg 
            580                 585                 590         


Ile Ile Met Gly Lys Ser His Val Phe Arg Phe Asn His Pro Glu Gln 
        595                 600                 605             


Ala Arg Gln Glu Arg Glu Arg Thr Pro Cys Ala Glu Thr Pro Ala Glu 
    610                 615                 620                 


Pro Val Asp Trp Ala Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln Gly 
625                 630                 635                 640 


Ile Asp Met Lys Gln Glu Met Glu Gln Arg Leu Gln Glu Leu Glu Asp 
                645                 650                 655     


Gln Tyr Arg Arg Glu Arg Glu Glu Ala Thr Tyr Leu Leu Glu Gln Gln 
            660                 665                 670         


Arg Leu Asp Tyr Glu Ser Lys Leu Glu Ala Leu Gln Lys Gln Met Asp 
        675                 680                 685             


Ser Arg Tyr Tyr Pro Glu Val Asn Glu Glu Glu Glu Glu Pro Glu Asp 
    690                 695                 700                 


Glu Val Gln Trp Thr Glu Arg Glu Cys Glu Leu Ala Leu Trp Ala Phe 
705                 710                 715                 720 


Arg Lys Trp Lys Trp Tyr Gln Phe Thr Ser Leu Arg Asp Leu Leu Trp 
                725                 730                 735     


Gly Asn Ala Ile Phe Leu Lys Glu Ala Asn Ala Ile Ser Val Glu Leu 
            740                 745                 750         


Lys Lys Lys Val Gln Phe Gln Phe Val Leu Leu Thr Asp Thr Leu Tyr 
        755                 760                 765             


Ser Pro Leu Pro Pro Asp Leu Leu Pro Pro Glu Ala Ala Lys Asp Arg 
    770                 775                 780                 


Glu Thr Arg Pro Phe Pro Arg Thr Ile Val Ala Val Glu Val Gln Asp 
785                 790                 795                 800 


Gln Lys Asn Gly Ala Thr His Tyr Trp Thr Leu Glu Lys Leu Arg Gln 
                805                 810                 815     


Arg Leu Asp Leu Met Arg Glu Met Tyr Asp Arg Ala Ala Glu Val Pro 
            820                 825                 830         


Ser Ser Val Ile Glu Asp Cys Asp Asn Val Val Thr Gly Gly Asp Pro 
        835                 840                 845             


Phe Tyr Asp Arg Phe Pro Trp Phe Arg Leu Val Gly Ser Ser Ala Ile 
    850                 855                 860                 


Ser Gly Cys Asn Ser Tyr Pro Leu Leu Asn Thr Cys Met Ser Glu Arg 
865                 870                 875                 880 


Met Ala Ala Leu Thr Pro Ser Pro Thr Phe Ser Ser Pro Asp Ser Asp 
                885                 890                 895     


Ala Thr Glu Pro Ala Glu Glu Gln Ser Val Gly Glu Glu Glu Glu Glu 
            900                 905                 910         


Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Asp Leu Glu Asp Asp Val 
        915                 920                 925             


Phe Pro Glu His Ala Leu Cys Asp Gly Arg Asp Pro Phe Tyr Asp Arg 
    930                 935                 940                 


Pro Pro Leu Phe Ser Leu Val Gly Arg Ala Phe Val Tyr Leu Ser Asn 
945                 950                 955                 960 


Leu Leu Tyr Pro Val Pro Leu Val His Arg Val Ala Ile Val Ser Glu 
                965                 970                 975     


Lys Gly Glu Val Lys Gly Phe Leu Arg Val Ala Val Gln Ala Ile Ser 
            980                 985                 990         


Ala Asp Glu Glu Ala Pro Asp Tyr  Gly Ser Gly Val Arg  Gln Ser Gly 
        995                 1000                 1005             


Thr Ala  Lys Ile Ser Phe Asp  Asp Gln His Phe Glu  Lys Phe Gln 
    1010                 1015                 1020             


Ser Glu  Ser Cys Pro Val Val  Gly Met Ser Arg Ser  Gly Thr Ser 
    1025                 1030                 1035             


Gln Glu  Glu Leu Arg Ile Val  Glu Gly Gln Gly Gln  Gly Ala Asp 
    1040                 1045                 1050             


Val Gly  Pro Ser Ala Asp Glu  Val Asn Asn Asn Thr  Cys Ser Ala 
    1055                 1060                 1065             


Val Pro  Pro Glu Gly Leu Leu  Leu Asp Ser Ser Glu  Lys Ala Ala 
    1070                 1075                 1080             


Leu Asp  Gly Pro Leu Asp Ala  Ala Leu Asp His Leu  Arg Leu Gly 
    1085                 1090                 1095             


Asn Thr  Phe Thr Phe Arg Val  Thr Val Leu Gln Ala  Ser Ser Ile 
    1100                 1105                 1110             


Ser Ala  Glu Tyr Ala Asp Ile  Phe Cys Gln Phe Asn  Phe Ile His 
    1115                 1120                 1125             


Arg His  Asp Glu Ala Phe Ser  Thr Glu Pro Leu Lys  Asn Thr Gly 
    1130                 1135                 1140             


Arg Gly  Pro Pro Leu Gly Phe  Tyr His Val Gln Asn  Ile Ala Val 
    1145                 1150                 1155             


Glu Val  Thr Lys Ser Phe Ile  Glu Tyr Ile Lys Ser  Gln Pro Ile 
    1160                 1165                 1170             


Val Phe  Glu Val Phe Gly His  Tyr Gln Gln His Pro  Phe Pro Pro 
    1175                 1180                 1185             


Leu Cys  Lys Asp Val Leu Ser  Pro Leu Arg Pro Ser  Arg Arg His 
    1190                 1195                 1200             


Phe Pro  Arg Val Met Pro Leu  Ser Lys Pro Val Pro  Ala Thr Lys 
    1205                 1210                 1215             


Leu Ser  Thr Leu Thr Arg Pro  Cys Pro Gly Pro Cys  His Cys Lys 
    1220                 1225                 1230             


Tyr Asp  Leu Leu Val Tyr Phe  Glu Ile Cys Glu Leu  Glu Ala Asn 
    1235                 1240                 1245             


Gly Asp  Tyr Ile Pro Ala Val  Val Asp His Arg Gly  Gly Met Pro 
    1250                 1255                 1260             


Cys Met  Gly Thr Phe Leu Leu  His Gln Gly Ile Gln  Arg Arg Ile 
    1265                 1270                 1275             


Thr Val  Thr Leu Leu His Glu  Thr Gly Ser His Ile  Arg Trp Lys 
    1280                 1285                 1290             


Glu Val  Arg Glu Leu Val Val  Gly Arg Ile Arg Asn  Thr Pro Glu 
    1295                 1300                 1305             


Thr Asp  Glu Ser Leu Ile Asp  Pro Asn Ile Leu Ser  Leu Asn Ile 
    1310                 1315                 1320             


Leu Ser  Ser Gly Tyr Ile His  Pro Ala Gln Asp Asp  Arg Thr Phe 
    1325                 1330                 1335             


Tyr Gln  Phe Glu Ala Ala Trp  Asp Ser Ser Met His  Asn Ser Leu 
    1340                 1345                 1350             


Leu Leu  Asn Arg Val Thr Pro  Tyr Arg Glu Lys Ile  Tyr Met Thr 
    1355                 1360                 1365             


Leu Ser  Ala Tyr Ile Glu Met  Glu Asn Cys Thr Gln  Pro Ala Val 
    1370                 1375                 1380             


Val Thr  Lys Asp Phe Cys Met  Val Phe Tyr Ser Arg  Asp Ala Lys 
    1385                 1390                 1395             


Leu Pro  Ala Ser Arg Ser Ile  Arg Asn Leu Phe Gly  Ser Gly Ser 
    1400                 1405                 1410             


Leu Arg  Ala Ser Glu Ser Asn  Arg Val Thr Gly Val  Tyr Glu Leu 
    1415                 1420                 1425             


Ser Leu  Cys His Val Ala Asp  Ala Gly Ser Pro Gly  Met Gln Arg 
    1430                 1435                 1440             


Arg Arg  Arg Arg Val Leu Asp  Thr Ser Val Ala Tyr  Val Arg Gly 
    1445                 1450                 1455             


Glu Glu  Asn Leu Ala Gly Trp  Arg Pro Arg Ser Asp  Ser Leu Ile 
    1460                 1465                 1470             


Leu Asp  His Gln Trp Glu Leu  Glu Lys Leu Ser Leu  Leu Gln Glu 
    1475                 1480                 1485             


Val Glu  Lys Thr Arg His Tyr  Leu Leu Leu Arg Glu  Lys Leu Glu 
    1490                 1495                 1500             


Thr Ala  Gln Arg Pro Val Pro  Glu Ala Leu Ser Pro  Ala Phe Ser 
    1505                 1510                 1515             


Glu Asp  Ser Glu Ser His Gly  Ser Ser Ser Ala Ser  Ser Pro Leu 
    1520                 1525                 1530             


Ser Ala  Glu Gly Arg Pro Ser  Pro Leu Glu Ala Pro  Asn Glu Arg 
    1535                 1540                 1545             


Gln Arg  Glu Leu Ala Val Lys  Cys Leu Arg Leu Leu  Thr His Thr 
    1550                 1555                 1560             


Phe Asn  Arg Glu Tyr Thr His  Ser His Val Cys Val  Ser Ala Ser 
    1565                 1570                 1575             


Glu Ser  Lys Leu Ser Glu Met  Ser Val Thr Leu Leu  Arg Asp Pro 
    1580                 1585                 1590             


Ser Met  Ser Pro Leu Gly Val  Ala Thr Leu Thr Pro  Ser Ser Thr 
    1595                 1600                 1605             


Cys Pro  Ser Leu Val Glu Gly  Arg Tyr Gly Ala Thr  Asp Leu Arg 
    1610                 1615                 1620             


Thr Pro  Gln Pro Cys Ser Arg  Pro Ala Ser Pro Glu  Pro Glu Leu 
    1625                 1630                 1635             


Leu Pro  Glu Ala Asp Ser Lys  Lys Leu Pro Ser Pro  Ala Arg Ala 
    1640                 1645                 1650             


Thr Glu  Thr Asp Lys Glu Pro  Gln Arg Leu Leu Val  Pro Asp Ile 
    1655                 1660                 1665             


Gln Glu  Ile Arg Val Ser Pro  Ile Val Ser Lys Lys  Gly Tyr Leu 
    1670                 1675                 1680             


His Phe  Leu Glu Pro His Thr  Ser Gly Trp Ala Arg  Arg Phe Val 
    1685                 1690                 1695             


Val Val  Arg Arg Pro Tyr Ala  Tyr Met Tyr Asn Ser  Asp Lys Asp 
    1700                 1705                 1710             


Thr Val  Glu Arg Phe Val Leu  Asn Leu Ala Thr Ala  Gln Val Glu 
    1715                 1720                 1725             


Tyr Ser  Glu Asp Gln Gln Ala  Met Leu Lys Thr Pro  Asn Thr Phe 
    1730                 1735                 1740             


Ala Val  Cys Thr Glu His Arg  Gly Ile Leu Leu Gln  Ala Ala Ser 
    1745                 1750                 1755             


Asp Lys  Asp Met His Asp Trp  Leu Tyr Ala Phe Asn  Pro Leu Leu 
    1760                 1765                 1770             


Ala Gly  Thr Ile Arg Ser Lys  Leu Ser Arg Arg Arg  Ser Ala Gln 
    1775                 1780                 1785             


Met Arg  Val 
    1790     


<210>  5876
<211>  1103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF1C__Homo_sapiens__NP_006603

<400>  5876

Met Ala Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn 
1               5                   10                  15      


Ala Arg Glu Thr Ser Gln Asp Ala Lys Cys Val Val Ser Met Gln Gly 
            20                  25                  30          


Asn Thr Thr Ser Ile Ile Asn Pro Lys Gln Ser Lys Asp Ala Pro Lys 
        35                  40                  45              


Ser Phe Thr Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Thr Glu Asp 
    50                  55                  60                  


Pro Gln Phe Ala Ser Gln Gln Gln Val Tyr Arg Asp Ile Gly Glu Glu 
65                  70                  75                  80  


Met Leu Leu His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Arg Gln Glu 
            100                 105                 110         


Pro Gly Gln Gln Gly Ile Val Pro Gln Leu Cys Glu Asp Leu Phe Ser 
        115                 120                 125             


Arg Val Ser Glu Asn Gln Ser Ala Gln Leu Ser Tyr Ser Val Glu Val 
    130                 135                 140                 


Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro 
145                 150                 155                 160 


Lys Ser Arg Gly Ser Leu Arg Val Arg Glu His Pro Ile Leu Gly Pro 
                165                 170                 175     


Tyr Val Gln Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Ala Asp Ile 
            180                 185                 190         


Ala Asp Leu Met Asp Cys Gly Asn Lys Ala Arg Thr Val Ala Ala Thr 
        195                 200                 205             


Asn Met Asn Glu Thr Ser Ser Arg Ser His Ala Val Phe Thr Ile Val 
    210                 215                 220                 


Phe Thr Gln Arg Cys His Asp Gln Leu Thr Gly Leu Asp Ser Glu Lys 
225                 230                 235                 240 


Val Ser Lys Ile Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Asp 
                245                 250                 255     


Ser Ser Gly Ala Arg Gly Met Arg Leu Lys Glu Gly Ala Asn Ile Asn 
            260                 265                 270         


Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Asp Met 
        275                 280                 285             


Gln Ser Lys Lys Arg Lys Ser Asp Phe Ile Pro Tyr Arg Asp Ser Val 
    290                 295                 300                 


Leu Thr Trp Leu Leu Lys Glu Asn Leu Gly Gly Asn Ser Arg Thr Ala 
305                 310                 315                 320 


Met Ile Ala Ala Leu Ser Pro Ala Asp Ile Asn Tyr Glu Glu Thr Leu 
                325                 330                 335     


Ser Thr Leu Arg Tyr Ala Asp Arg Thr Lys Gln Ile Arg Cys Asn Ala 
            340                 345                 350         


Ile Ile Asn Glu Asp Pro Asn Ala Arg Leu Ile Arg Glu Leu Gln Glu 
        355                 360                 365             


Glu Val Ala Arg Leu Arg Glu Leu Leu Met Ala Gln Gly Leu Ser Ala 
    370                 375                 380                 


Ser Ala Leu Glu Gly Leu Lys Thr Glu Glu Gly Ser Val Arg Gly Ala 
385                 390                 395                 400 


Leu Pro Ala Val Ser Ser Pro Pro Ala Pro Val Ser Pro Ser Ser Pro 
                405                 410                 415     


Thr Thr His Asn Gly Glu Leu Glu Pro Ser Phe Ser Pro Asn Thr Glu 
            420                 425                 430         


Ser Gln Ile Gly Pro Glu Glu Ala Met Glu Arg Leu Gln Glu Thr Glu 
        435                 440                 445             


Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys Leu Arg Lys 
    450                 455                 460                 


Thr Glu Ala Leu Arg Met Glu Arg Glu Ala Leu Leu Ala Glu Met Gly 
465                 470                 475                 480 


Val Ala Val Arg Glu Asp Gly Gly Thr Val Gly Val Phe Ser Pro Lys 
                485                 490                 495     


Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu Met Ser Glu 
            500                 505                 510         


Cys Leu Leu Tyr His Ile Lys Asp Gly Val Thr Arg Val Gly Gln Val 
        515                 520                 525             


Asp Met Asp Ile Lys Leu Thr Gly Gln Phe Ile Arg Glu Gln His Cys 
    530                 535                 540                 


Leu Phe Arg Ser Ile Pro Gln Pro Asp Gly Glu Val Val Val Thr Leu 
545                 550                 555                 560 


Glu Pro Cys Glu Gly Ala Glu Thr Tyr Val Asn Gly Lys Leu Val Thr 
                565                 570                 575     


Glu Pro Leu Val Leu Lys Ser Gly Asn Arg Ile Val Met Gly Lys Asn 
            580                 585                 590         


His Val Phe Arg Phe Asn His Pro Glu Gln Ala Arg Leu Glu Arg Glu 
        595                 600                 605             


Arg Gly Val Pro Pro Pro Pro Gly Pro Pro Ser Glu Pro Val Asp Trp 
    610                 615                 620                 


Asn Phe Ala Gln Lys Glu Leu Leu Glu Gln Gln Gly Ile Asp Ile Lys 
625                 630                 635                 640 


Leu Glu Met Glu Lys Arg Leu Gln Asp Leu Glu Asn Gln Tyr Arg Lys 
                645                 650                 655     


Glu Lys Glu Glu Ala Asp Leu Leu Leu Glu Gln Gln Arg Leu Tyr Ala 
            660                 665                 670         


Asp Ser Asp Ser Gly Asp Asp Ser Asp Lys Arg Ser Cys Glu Glu Ser 
        675                 680                 685             


Trp Arg Leu Ile Ser Ser Leu Arg Glu Gln Leu Pro Pro Thr Thr Val 
    690                 695                 700                 


Gln Thr Ile Val Lys Arg Cys Gly Leu Pro Ser Ser Gly Lys Arg Arg 
705                 710                 715                 720 


Ala Pro Arg Arg Val Tyr Gln Ile Pro Gln Arg Arg Arg Leu Gln Gly 
                725                 730                 735     


Lys Asp Pro Arg Trp Ala Thr Met Ala Asp Leu Lys Met Gln Ala Val 
            740                 745                 750         


Lys Glu Ile Cys Tyr Glu Val Ala Leu Ala Asp Phe Arg His Gly Arg 
        755                 760                 765             


Ala Glu Ile Glu Ala Leu Ala Ala Leu Lys Met Arg Glu Leu Cys Arg 
    770                 775                 780                 


Thr Tyr Gly Lys Pro Asp Gly Pro Gly Asp Ala Trp Arg Ala Val Ala 
785                 790                 795                 800 


Arg Asp Val Trp Asp Thr Val Gly Glu Glu Glu Gly Gly Gly Ala Gly 
                805                 810                 815     


Ser Gly Gly Gly Ser Glu Glu Gly Ala Arg Gly Ala Glu Val Glu Asp 
            820                 825                 830         


Leu Arg Ala His Ile Asp Lys Leu Thr Gly Ile Leu Gln Glu Val Lys 
        835                 840                 845             


Leu Gln Asn Ser Ser Lys Asp Arg Glu Leu Gln Ala Leu Arg Asp Arg 
    850                 855                 860                 


Met Leu Arg Met Glu Arg Val Ile Pro Leu Ala Gln Asp His Glu Asp 
865                 870                 875                 880 


Glu Asn Glu Glu Gly Gly Glu Val Pro Trp Ala Pro Pro Glu Gly Ser 
                885                 890                 895     


Glu Ala Ala Glu Glu Ala Ala Pro Ser Asp Arg Met Pro Ser Ala Arg 
            900                 905                 910         


Pro Pro Ser Pro Pro Leu Ser Ser Trp Glu Arg Val Ser Arg Leu Met 
        915                 920                 925             


Glu Glu Asp Pro Ala Phe Arg Arg Gly Arg Leu Arg Trp Leu Lys Gln 
    930                 935                 940                 


Glu Gln Leu Arg Leu Gln Gly Leu Gln Gly Ser Gly Gly Arg Gly Gly 
945                 950                 955                 960 


Gly Leu Arg Arg Pro Pro Ala Arg Phe Val Pro Pro His Asp Cys Lys 
                965                 970                 975     


Leu Arg Phe Pro Phe Lys Ser Asn Pro Gln His Arg Glu Ser Trp Pro 
            980                 985                 990         


Gly Met Gly Ser Gly Glu Ala Pro  Thr Pro Leu Gln Pro  Pro Glu Glu 
        995                 1000                 1005             


Val Thr  Pro His Pro Ala Thr  Pro Ala Arg Arg Pro  Pro Ser Pro 
    1010                 1015                 1020             


Arg Arg  Ser His His Pro Arg  Arg Asn Ser Leu Asp  Gly Gly Gly 
    1025                 1030                 1035             


Arg Ser  Arg Gly Ala Gly Ser  Ala Gln Pro Glu Pro  Gln His Phe 
    1040                 1045                 1050             


Gln Pro  Lys Lys His Asn Ser  Tyr Pro Gln Pro Pro  Gln Pro Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Arg Pro Pro Gly  Pro Arg Tyr Pro Pro  Tyr Thr Thr 
    1070                 1075                 1080             


Pro Pro  Arg Met Arg Arg Gln  Arg Ser Ala Pro Asp  Leu Lys Glu 
    1085                 1090                 1095             


Ser Gly  Ala Ala Val 
    1100             


<210>  5877
<211>  890
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF20A__Homo_sapiens__NP_005724

<400>  5877

Met Ser Gln Gly Ile Leu Ser Pro Pro Ala Gly Leu Leu Ser Asp Asp 
1               5                   10                  15      


Asp Val Val Val Ser Pro Met Phe Glu Ser Thr Ala Ala Asp Leu Gly 
            20                  25                  30          


Ser Val Val Arg Lys Asn Leu Leu Ser Asp Cys Ser Val Val Ser Thr 
        35                  40                  45              


Ser Leu Glu Asp Lys Gln Gln Val Pro Ser Glu Asp Ser Met Glu Lys 
    50                  55                  60                  


Val Lys Val Tyr Leu Arg Val Arg Pro Leu Leu Pro Ser Glu Leu Glu 
65                  70                  75                  80  


Arg Gln Glu Asp Gln Gly Cys Val Arg Ile Glu Asn Val Glu Thr Leu 
                85                  90                  95      


Val Leu Gln Ala Pro Lys Asp Ser Phe Ala Leu Lys Ser Asn Glu Arg 
            100                 105                 110         


Gly Ile Gly Gln Ala Thr His Arg Phe Thr Phe Ser Gln Ile Phe Gly 
        115                 120                 125             


Pro Glu Val Gly Gln Ala Ser Phe Phe Asn Leu Thr Val Lys Glu Met 
    130                 135                 140                 


Val Lys Asp Val Leu Lys Gly Gln Asn Trp Leu Ile Tyr Thr Tyr Gly 
145                 150                 155                 160 


Val Thr Asn Ser Gly Lys Thr His Thr Ile Gln Gly Thr Ile Lys Asp 
                165                 170                 175     


Gly Gly Ile Leu Pro Arg Ser Leu Ala Leu Ile Phe Asn Ser Leu Gln 
            180                 185                 190         


Gly Gln Leu His Pro Thr Pro Asp Leu Lys Pro Leu Leu Ser Asn Glu 
        195                 200                 205             


Val Ile Trp Leu Asp Ser Lys Gln Ile Arg Gln Glu Glu Met Lys Lys 
    210                 215                 220                 


Leu Ser Leu Leu Asn Gly Gly Leu Gln Glu Glu Glu Leu Ser Thr Ser 
225                 230                 235                 240 


Leu Lys Arg Ser Val Tyr Ile Glu Ser Arg Ile Gly Thr Ser Thr Ser 
                245                 250                 255     


Phe Asp Ser Gly Ile Ala Gly Leu Ser Ser Ile Ser Gln Cys Thr Ser 
            260                 265                 270         


Ser Ser Gln Leu Asp Glu Thr Ser His Arg Trp Ala Gln Pro Asp Thr 
        275                 280                 285             


Ala Pro Leu Pro Val Pro Ala Asn Ile Arg Phe Ser Ile Trp Ile Ser 
    290                 295                 300                 


Phe Phe Glu Ile Tyr Asn Glu Leu Leu Tyr Asp Leu Leu Glu Pro Pro 
305                 310                 315                 320 


Ser Gln Gln Arg Lys Arg Gln Thr Leu Arg Leu Cys Glu Asp Gln Asn 
                325                 330                 335     


Gly Asn Pro Tyr Val Lys Asp Leu Asn Trp Ile His Val Gln Asp Ala 
            340                 345                 350         


Glu Glu Ala Trp Lys Leu Leu Lys Val Gly Arg Lys Asn Gln Ser Phe 
        355                 360                 365             


Ala Ser Thr His Leu Asn Gln Asn Ser Ser Arg Ser His Ser Ile Phe 
    370                 375                 380                 


Ser Ile Arg Ile Leu His Leu Gln Gly Glu Gly Asp Ile Val Pro Lys 
385                 390                 395                 400 


Ile Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser Glu Arg Cys Lys 
                405                 410                 415     


Asp Gln Lys Ser Gly Glu Arg Leu Lys Glu Ala Gly Asn Ile Asn Thr 
            420                 425                 430         


Ser Leu His Thr Leu Gly Arg Cys Ile Ala Ala Leu Arg Gln Asn Gln 
        435                 440                 445             


Gln Asn Arg Ser Lys Gln Asn Leu Val Pro Phe Arg Asp Ser Lys Leu 
    450                 455                 460                 


Thr Arg Val Phe Gln Gly Phe Phe Thr Gly Arg Gly Arg Ser Cys Met 
465                 470                 475                 480 


Ile Val Asn Val Asn Pro Cys Ala Ser Thr Tyr Asp Glu Thr Leu His 
                485                 490                 495     


Val Ala Lys Phe Ser Ala Ile Ala Ser Gln Leu Val His Ala Pro Pro 
            500                 505                 510         


Met Gln Leu Gly Phe Pro Ser Leu His Ser Phe Ile Lys Glu His Ser 
        515                 520                 525             


Leu Gln Val Ser Pro Ser Leu Glu Lys Gly Ala Lys Ala Asp Thr Gly 
    530                 535                 540                 


Leu Asp Asp Asp Ile Glu Asn Glu Ala Asp Ile Ser Met Tyr Gly Lys 
545                 550                 555                 560 


Glu Glu Leu Leu Gln Val Val Glu Ala Met Lys Thr Leu Leu Leu Lys 
                565                 570                 575     


Glu Arg Gln Glu Lys Leu Gln Leu Glu Met His Leu Arg Asp Glu Ile 
            580                 585                 590         


Cys Asn Glu Met Val Glu Gln Met Gln Gln Arg Glu Gln Trp Cys Ser 
        595                 600                 605             


Glu His Leu Asp Thr Gln Lys Glu Leu Leu Glu Glu Met Tyr Glu Glu 
    610                 615                 620                 


Lys Leu Asn Ile Leu Lys Glu Ser Leu Thr Ser Phe Tyr Gln Glu Glu 
625                 630                 635                 640 


Ile Gln Glu Arg Asp Glu Lys Ile Glu Glu Leu Glu Ala Leu Leu Gln 
                645                 650                 655     


Glu Ala Arg Gln Gln Ser Val Ala His Gln Gln Ser Gly Ser Glu Leu 
            660                 665                 670         


Ala Leu Arg Arg Ser Gln Arg Leu Ala Ala Ser Ala Ser Thr Gln Gln 
        675                 680                 685             


Leu Gln Glu Val Lys Ala Lys Leu Gln Gln Cys Lys Ala Glu Leu Asn 
    690                 695                 700                 


Ser Thr Thr Glu Glu Leu His Lys Tyr Gln Lys Met Leu Glu Pro Pro 
705                 710                 715                 720 


Pro Ser Ala Lys Pro Phe Thr Ile Asp Val Asp Lys Lys Leu Glu Glu 
                725                 730                 735     


Gly Gln Lys Asn Ile Arg Leu Leu Arg Thr Glu Leu Gln Lys Leu Gly 
            740                 745                 750         


Glu Ser Leu Gln Ser Ala Glu Arg Ala Cys Cys His Ser Thr Gly Ala 
        755                 760                 765             


Gly Lys Leu Arg Gln Ala Leu Thr Thr Cys Asp Asp Ile Leu Ile Lys 
    770                 775                 780                 


Gln Asp Gln Thr Leu Ala Glu Leu Gln Asn Asn Met Val Leu Val Lys 
785                 790                 795                 800 


Leu Asp Leu Arg Lys Lys Ala Ala Cys Ile Ala Glu Gln Tyr His Thr 
                805                 810                 815     


Val Leu Lys Leu Gln Gly Gln Val Ser Ala Lys Lys Arg Leu Gly Thr 
            820                 825                 830         


Asn Gln Glu Asn Gln Gln Pro Asn Gln Gln Pro Pro Gly Lys Lys Pro 
        835                 840                 845             


Phe Leu Arg Asn Leu Leu Pro Arg Thr Pro Thr Cys Gln Ser Ser Thr 
    850                 855                 860                 


Asp Cys Ser Pro Tyr Ala Arg Ile Leu Arg Ser Arg Arg Ser Pro Leu 
865                 870                 875                 880 


Leu Lys Ser Gly Pro Phe Gly Lys Lys Tyr 
                885                 890 


<210>  5878
<211>  1820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF20B__Homo_sapiens__NP_001271188

<400>  5878

Met Glu Ser Asn Phe Asn Gln Glu Gly Val Pro Arg Pro Ser Tyr Val 
1               5                   10                  15      


Phe Ser Ala Asp Pro Ile Ala Arg Pro Ser Glu Ile Asn Phe Asp Gly 
            20                  25                  30          


Ile Lys Leu Asp Leu Ser His Glu Phe Ser Leu Val Ala Pro Asn Thr 
        35                  40                  45              


Glu Ala Asn Ser Phe Glu Ser Lys Asp Tyr Leu Gln Val Cys Leu Arg 
    50                  55                  60                  


Ile Arg Pro Phe Thr Gln Ser Glu Lys Glu Leu Glu Ser Glu Gly Cys 
65                  70                  75                  80  


Val His Ile Leu Asp Ser Gln Thr Val Val Leu Lys Glu Pro Gln Cys 
                85                  90                  95      


Ile Leu Gly Arg Leu Ser Glu Lys Ser Ser Gly Gln Met Ala Gln Lys 
            100                 105                 110         


Phe Ser Phe Ser Lys Val Phe Gly Pro Ala Thr Thr Gln Lys Glu Phe 
        115                 120                 125             


Phe Gln Gly Cys Ile Met Gln Pro Val Lys Asp Leu Leu Lys Gly Gln 
    130                 135                 140                 


Ser Arg Leu Ile Phe Thr Tyr Gly Leu Thr Asn Ser Gly Lys Thr Tyr 
145                 150                 155                 160 


Thr Phe Gln Gly Thr Glu Glu Asn Ile Gly Ile Leu Pro Arg Thr Leu 
                165                 170                 175     


Asn Val Leu Phe Asp Ser Leu Gln Glu Arg Leu Tyr Thr Lys Met Asn 
            180                 185                 190         


Leu Lys Pro His Arg Ser Arg Glu Tyr Leu Arg Leu Ser Ser Glu Gln 
        195                 200                 205             


Glu Lys Glu Glu Ile Ala Ser Lys Ser Ala Leu Leu Arg Gln Ile Lys 
    210                 215                 220                 


Glu Val Thr Val His Asn Asp Ser Asp Asp Thr Leu Tyr Gly Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Leu Asn Ile Ser Glu Phe Glu Glu Ser Ile Lys Asp Tyr 
                245                 250                 255     


Glu Gln Ala Asn Leu Asn Met Ala Asn Ser Ile Lys Phe Ser Val Trp 
            260                 265                 270         


Val Ser Phe Phe Glu Ile Tyr Asn Glu Tyr Ile Tyr Asp Leu Phe Val 
        275                 280                 285             


Pro Val Ser Ser Lys Phe Gln Lys Arg Lys Met Leu Arg Leu Ser Gln 
    290                 295                 300                 


Asp Val Lys Gly Tyr Ser Phe Ile Lys Asp Leu Gln Trp Ile Gln Val 
305                 310                 315                 320 


Ser Asp Ser Lys Glu Ala Tyr Arg Leu Leu Lys Leu Gly Ile Lys His 
                325                 330                 335     


Gln Ser Val Ala Phe Thr Lys Leu Asn Asn Ala Ser Ser Arg Ser His 
            340                 345                 350         


Ser Ile Phe Thr Val Lys Ile Leu Gln Ile Glu Asp Ser Glu Met Ser 
        355                 360                 365             


Arg Val Ile Arg Val Ser Glu Leu Ser Leu Cys Asp Leu Ala Gly Ser 
    370                 375                 380                 


Glu Arg Thr Met Lys Thr Gln Asn Glu Gly Glu Arg Leu Arg Glu Thr 
385                 390                 395                 400 


Gly Asn Ile Asn Thr Ser Leu Leu Thr Leu Gly Lys Cys Ile Asn Val 
                405                 410                 415     


Leu Lys Asn Ser Glu Lys Ser Lys Phe Gln Gln His Val Pro Phe Arg 
            420                 425                 430         


Glu Ser Lys Leu Thr His Tyr Phe Gln Ser Phe Phe Asn Gly Lys Gly 
        435                 440                 445             


Lys Ile Cys Met Ile Val Asn Ile Ser Gln Cys Tyr Leu Ala Tyr Asp 
    450                 455                 460                 


Glu Thr Leu Asn Val Leu Lys Phe Ser Ala Ile Ala Gln Lys Val Cys 
465                 470                 475                 480 


Val Pro Asp Thr Leu Asn Ser Ser Gln Glu Lys Leu Phe Gly Pro Val 
                485                 490                 495     


Lys Ser Ser Gln Asp Val Ser Leu Asp Ser Asn Ser Asn Ser Lys Ile 
            500                 505                 510         


Leu Asn Val Lys Arg Ala Thr Ile Ser Trp Glu Asn Ser Leu Glu Asp 
        515                 520                 525             


Leu Met Glu Asp Glu Asp Leu Val Glu Glu Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


Thr Gln Asn Val Glu Thr Lys Leu Leu Asp Glu Asp Leu Asp Lys Thr 
545                 550                 555                 560 


Leu Glu Glu Asn Lys Ala Phe Ile Ser His Glu Glu Lys Arg Lys Leu 
                565                 570                 575     


Leu Asp Leu Ile Glu Asp Leu Lys Lys Lys Leu Ile Asn Glu Lys Lys 
            580                 585                 590         


Glu Lys Leu Thr Leu Glu Phe Lys Ile Arg Glu Glu Val Thr Gln Glu 
        595                 600                 605             


Phe Thr Gln Tyr Trp Ala Gln Arg Glu Ala Asp Phe Lys Glu Thr Leu 
    610                 615                 620                 


Leu Gln Glu Arg Glu Ile Leu Glu Glu Asn Ala Glu Arg Arg Leu Ala 
625                 630                 635                 640 


Ile Phe Lys Asp Leu Val Gly Lys Cys Asp Thr Arg Glu Glu Ala Ala 
                645                 650                 655     


Lys Asp Ile Cys Ala Thr Lys Val Glu Thr Glu Glu Thr His Asn Tyr 
            660                 665                 670         


Val Gly Phe Glu Asp Ile Ile Asp Ser Leu Gln Asp Asn Val Ala Asp 
        675                 680                 685             


Ile Lys Lys Gln Ala Glu Ile Ala His Leu Tyr Ile Ala Ser Leu Pro 
    690                 695                 700                 


Asp Pro Gln Glu Ala Thr Ala Cys Leu Glu Leu Lys Phe Asn Gln Ile 
705                 710                 715                 720 


Lys Ala Glu Leu Ala Lys Thr Lys Gly Glu Leu Ile Lys Thr Lys Glu 
                725                 730                 735     


Glu Leu Lys Lys Arg Glu Asn Glu Ser Asp Ser Leu Ile Gln Glu Leu 
            740                 745                 750         


Glu Thr Ser Asn Lys Lys Ile Ile Thr Gln Asn Gln Arg Ile Lys Glu 
        755                 760                 765             


Leu Ile Asn Ile Ile Asp Gln Lys Glu Asp Thr Ile Asn Glu Phe Gln 
    770                 775                 780                 


Asn Leu Lys Ser His Met Glu Asn Thr Phe Lys Cys Asn Asp Lys Ala 
785                 790                 795                 800 


Asp Thr Ser Ser Leu Ile Ile Asn Asn Lys Leu Ile Cys Asn Glu Thr 
                805                 810                 815     


Val Glu Val Pro Lys Asp Ser Lys Ser Lys Ile Cys Ser Glu Arg Lys 
            820                 825                 830         


Arg Val Asn Glu Asn Glu Leu Gln Gln Asp Glu Pro Pro Ala Lys Lys 
        835                 840                 845             


Gly Ser Ile His Val Ser Ser Ala Ile Thr Glu Asp Gln Lys Lys Ser 
    850                 855                 860                 


Glu Glu Val Arg Pro Asn Ile Ala Glu Ile Glu Asp Ile Arg Val Leu 
865                 870                 875                 880 


Gln Glu Asn Asn Glu Gly Leu Arg Ala Phe Leu Leu Thr Ile Glu Asn 
                885                 890                 895     


Glu Leu Lys Asn Glu Lys Glu Glu Lys Ala Glu Leu Asn Lys Gln Ile 
            900                 905                 910         


Val His Phe Gln Gln Glu Leu Ser Leu Ser Glu Lys Lys Asn Leu Thr 
        915                 920                 925             


Leu Ser Lys Glu Val Gln Gln Ile Gln Ser Asn Tyr Asp Ile Ala Ile 
    930                 935                 940                 


Ala Glu Leu His Val Gln Lys Ser Lys Asn Gln Glu Gln Glu Glu Lys 
945                 950                 955                 960 


Ile Met Lys Leu Ser Asn Glu Ile Glu Thr Ala Thr Arg Ser Ile Thr 
                965                 970                 975     


Asn Asn Val Ser Gln Ile Lys Leu Met His Thr Lys Ile Asp Glu Leu 
            980                 985                 990         


Arg Thr Leu Asp Ser Val Ser Gln  Ile Ser Asn Ile Asp  Leu Leu Asn 
        995                 1000                 1005             


Leu Arg  Asp Leu Ser Asn Gly  Ser Glu Glu Asp Asn  Leu Pro Asn 
    1010                 1015                 1020             


Thr Gln  Leu Asp Leu Leu Gly  Asn Asp Tyr Leu Val  Ser Lys Gln 
    1025                 1030                 1035             


Val Lys  Glu Tyr Arg Ile Gln  Glu Pro Asn Arg Glu  Asn Ser Phe 
    1040                 1045                 1050             


His Ser  Ser Ile Glu Ala Ile  Trp Glu Glu Cys Lys  Glu Ile Val 
    1055                 1060                 1065             


Lys Ala  Ser Ser Lys Lys Ser  His Gln Ile Glu Glu  Leu Glu Gln 
    1070                 1075                 1080             


Gln Ile  Glu Lys Leu Gln Ala  Glu Val Lys Gly Tyr  Lys Asp Glu 
    1085                 1090                 1095             


Asn Asn  Arg Leu Lys Glu Lys  Glu His Lys Asn Gln  Asp Asp Leu 
    1100                 1105                 1110             


Leu Lys  Glu Lys Glu Thr Leu  Ile Gln Gln Leu Lys  Glu Glu Leu 
    1115                 1120                 1125             


Gln Glu  Lys Asn Val Thr Leu  Asp Val Gln Ile Gln  His Val Val 
    1130                 1135                 1140             


Glu Gly  Lys Arg Ala Leu Ser  Glu Leu Thr Gln Gly  Val Thr Cys 
    1145                 1150                 1155             


Tyr Lys  Ala Lys Ile Lys Glu  Leu Glu Thr Ile Leu  Glu Thr Gln 
    1160                 1165                 1170             


Lys Val  Glu Cys Ser His Ser  Ala Lys Leu Glu Gln  Asp Ile Leu 
    1175                 1180                 1185             


Glu Lys  Glu Ser Ile Ile Leu  Lys Leu Glu Arg Asn  Leu Lys Glu 
    1190                 1195                 1200             


Phe Gln  Glu His Leu Gln Asp  Ser Val Lys Asn Thr  Lys Asp Leu 
    1205                 1210                 1215             


Asn Val  Lys Glu Leu Lys Leu  Lys Glu Glu Ile Thr  Gln Leu Thr 
    1220                 1225                 1230             


Asn Asn  Leu Gln Asp Met Lys  His Leu Leu Gln Leu  Lys Glu Glu 
    1235                 1240                 1245             


Glu Glu  Glu Thr Asn Arg Gln  Glu Thr Glu Lys Leu  Lys Glu Glu 
    1250                 1255                 1260             


Leu Ser  Ala Ser Ser Ala Arg  Thr Gln Asn Leu Lys  Ala Asp Leu 
    1265                 1270                 1275             


Gln Arg  Lys Glu Glu Asp Tyr  Ala Asp Leu Lys Glu  Lys Leu Thr 
    1280                 1285                 1290             


Asp Ala  Lys Lys Gln Ile Lys  Gln Val Gln Lys Glu  Val Ser Val 
    1295                 1300                 1305             


Met Arg  Asp Glu Asp Lys Leu  Leu Arg Ile Lys Ile  Asn Glu Leu 
    1310                 1315                 1320             


Glu Lys  Lys Lys Asn Gln Cys  Ser Gln Glu Leu Asp  Met Lys Gln 
    1325                 1330                 1335             


Arg Thr  Ile Gln Gln Leu Lys  Glu Gln Leu Asn Asn  Gln Lys Val 
    1340                 1345                 1350             


Glu Glu  Ala Ile Gln Gln Tyr  Glu Arg Ala Cys Lys  Asp Leu Asn 
    1355                 1360                 1365             


Val Lys  Glu Lys Ile Ile Glu  Asp Met Arg Met Thr  Leu Glu Glu 
    1370                 1375                 1380             


Gln Glu  Gln Thr Gln Val Glu  Gln Asp Gln Val Leu  Glu Ala Lys 
    1385                 1390                 1395             


Leu Glu  Glu Val Glu Arg Leu  Ala Thr Glu Leu Glu  Lys Trp Lys 
    1400                 1405                 1410             


Glu Lys  Cys Asn Asp Leu Glu  Thr Lys Asn Asn Gln  Arg Ser Asn 
    1415                 1420                 1425             


Lys Glu  His Glu Asn Asn Thr  Asp Val Leu Gly Lys  Leu Thr Asn 
    1430                 1435                 1440             


Leu Gln  Asp Glu Leu Gln Glu  Ser Glu Gln Lys Tyr  Asn Ala Asp 
    1445                 1450                 1455             


Arg Lys  Lys Trp Leu Glu Glu  Lys Met Met Leu Ile  Thr Gln Ala 
    1460                 1465                 1470             


Lys Glu  Ala Glu Asn Ile Arg  Asn Lys Glu Met Lys  Lys Tyr Ala 
    1475                 1480                 1485             


Glu Asp  Arg Glu Arg Phe Phe  Lys Gln Gln Asn Glu  Met Glu Ile 
    1490                 1495                 1500             


Leu Thr  Ala Gln Leu Thr Glu  Lys Asp Ser Asp Leu  Gln Lys Trp 
    1505                 1510                 1515             


Arg Glu  Glu Arg Asp Gln Leu  Val Ala Ala Leu Glu  Ile Gln Leu 
    1520                 1525                 1530             


Lys Ala  Leu Ile Ser Ser Asn  Val Gln Lys Asp Asn  Glu Ile Glu 
    1535                 1540                 1545             


Gln Leu  Lys Arg Ile Ile Ser  Glu Thr Ser Lys Ile  Glu Thr Gln 
    1550                 1555                 1560             


Ile Met  Asp Ile Lys Pro Lys  Arg Ile Ser Ser Ala  Asp Pro Asp 
    1565                 1570                 1575             


Lys Leu  Gln Thr Glu Pro Leu  Ser Thr Ser Phe Glu  Ile Ser Arg 
    1580                 1585                 1590             


Asn Lys  Ile Glu Asp Gly Ser  Val Val Leu Asp Ser  Cys Glu Val 
    1595                 1600                 1605             


Ser Thr  Glu Asn Asp Gln Ser  Thr Arg Phe Pro Lys  Pro Glu Leu 
    1610                 1615                 1620             


Glu Ile  Gln Phe Thr Pro Leu  Gln Pro Asn Lys Met  Ala Val Lys 
    1625                 1630                 1635             


His Pro  Gly Cys Thr Thr Pro  Val Thr Val Lys Ile  Pro Lys Ala 
    1640                 1645                 1650             


Arg Lys  Arg Lys Ser Asn Glu  Met Glu Glu Asp Leu  Val Lys Cys 
    1655                 1660                 1665             


Glu Asn  Lys Lys Asn Ala Thr  Pro Arg Thr Asn Leu  Lys Phe Pro 
    1670                 1675                 1680             


Ile Ser  Asp Asp Arg Asn Ser  Ser Val Lys Lys Glu  Gln Lys Val 
    1685                 1690                 1695             


Ala Ile  Arg Pro Ser Ser Lys  Lys Thr Tyr Ser Leu  Arg Ser Gln 
    1700                 1705                 1710             


Ala Ser  Ile Ile Gly Val Asn  Leu Ala Thr Lys Lys  Lys Glu Gly 
    1715                 1720                 1725             


Thr Leu  Gln Lys Phe Gly Asp  Phe Leu Gln His Ser  Pro Ser Ile 
    1730                 1735                 1740             


Leu Gln  Ser Lys Ala Lys Lys  Ile Ile Glu Thr Met  Ser Ser Ser 
    1745                 1750                 1755             


Lys Leu  Ser Asn Val Glu Ala  Ser Lys Glu Asn Val  Ser Gln Pro 
    1760                 1765                 1770             


Lys Arg  Ala Lys Arg Lys Leu  Tyr Thr Ser Glu Ile  Ser Ser Pro 
    1775                 1780                 1785             


Ile Asp  Ile Ser Gly Gln Val  Ile Leu Met Asp Gln  Lys Met Lys 
    1790                 1795                 1800             


Glu Ser  Asp His Gln Ile Ile  Lys Arg Arg Leu Arg  Thr Lys Thr 
    1805                 1810                 1815             


Ala Lys  
    1820 


<210>  5879
<211>  1637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF21A__Homo_sapiens__NP_001166934

<400>  5879

Met Leu Gly Ala Pro Asp Glu Ser Ser Val Arg Val Ala Val Arg Ile 
1               5                   10                  15      


Arg Pro Gln Leu Ala Lys Glu Lys Ile Glu Gly Cys His Ile Cys Thr 
            20                  25                  30          


Ser Val Thr Pro Gly Glu Pro Gln Val Phe Leu Gly Lys Asp Lys Ala 
        35                  40                  45              


Phe Thr Phe Asp Tyr Val Phe Asp Ile Asp Ser Gln Gln Glu Gln Ile 
    50                  55                  60                  


Tyr Ile Gln Cys Ile Glu Lys Leu Ile Glu Gly Cys Phe Glu Gly Tyr 
65                  70                  75                  80  


Asn Ala Thr Val Phe Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr Tyr 
                85                  90                  95      


Thr Met Gly Thr Gly Phe Asp Val Asn Ile Val Glu Glu Glu Leu Gly 
            100                 105                 110         


Ile Ile Ser Arg Ala Val Lys His Leu Phe Lys Ser Ile Glu Glu Lys 
        115                 120                 125             


Lys His Ile Ala Ile Lys Asn Gly Leu Pro Ala Pro Asp Phe Lys Val 
    130                 135                 140                 


Asn Ala Gln Phe Leu Glu Leu Tyr Asn Glu Glu Val Leu Asp Leu Phe 
145                 150                 155                 160 


Asp Thr Thr Arg Asp Ile Asp Ala Lys Ser Lys Lys Ser Asn Ile Arg 
                165                 170                 175     


Ile His Glu Asp Ser Thr Gly Gly Ile Tyr Thr Val Gly Val Thr Thr 
            180                 185                 190         


Arg Thr Val Asn Thr Glu Ser Glu Met Met Gln Cys Leu Lys Leu Gly 
        195                 200                 205             


Ala Leu Ser Arg Thr Thr Ala Ser Thr Gln Met Asn Val Gln Ser Ser 
    210                 215                 220                 


Arg Ser His Ala Ile Phe Thr Ile His Val Cys Gln Thr Arg Val Cys 
225                 230                 235                 240 


Pro Gln Ile Asp Ala Asp Asn Ala Thr Asp Asn Lys Ile Ile Ser Glu 
                245                 250                 255     


Ser Ala Gln Met Asn Glu Phe Glu Thr Leu Thr Ala Lys Phe His Phe 
            260                 265                 270         


Val Asp Leu Ala Gly Ser Glu Arg Leu Lys Arg Thr Gly Ala Thr Gly 
        275                 280                 285             


Glu Arg Ala Lys Glu Gly Ile Ser Ile Asn Cys Gly Leu Leu Ala Leu 
    290                 295                 300                 


Gly Asn Val Ile Ser Ala Leu Gly Asp Lys Ser Lys Arg Ala Thr His 
305                 310                 315                 320 


Val Pro Tyr Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu 
                325                 330                 335     


Gly Gly Asn Ser Gln Thr Ile Met Ile Ala Cys Val Ser Pro Ser Asp 
            340                 345                 350         


Arg Asp Phe Met Glu Thr Leu Asn Thr Leu Lys Tyr Ala Asn Arg Ala 
        355                 360                 365             


Arg Asn Ile Lys Asn Lys Val Met Val Asn Gln Asp Arg Ala Ser Gln 
    370                 375                 380                 


Gln Ile Asn Ala Leu Arg Ser Glu Ile Thr Arg Leu Gln Met Glu Leu 
385                 390                 395                 400 


Met Glu Tyr Lys Thr Gly Lys Arg Ile Ile Asp Glu Glu Gly Val Glu 
                405                 410                 415     


Ser Ile Asn Asp Met Phe His Glu Asn Ala Met Leu Gln Thr Glu Asn 
            420                 425                 430         


Asn Asn Leu Arg Val Arg Ile Lys Ala Met Gln Glu Thr Val Asp Ala 
        435                 440                 445             


Leu Arg Ser Arg Ile Thr Gln Leu Val Ser Asp Gln Ala Asn His Val 
    450                 455                 460                 


Leu Ala Arg Ala Gly Glu Gly Asn Glu Glu Ile Ser Asn Met Ile His 
465                 470                 475                 480 


Ser Tyr Ile Lys Glu Ile Glu Asp Leu Arg Ala Lys Leu Leu Glu Ser 
                485                 490                 495     


Glu Ala Val Asn Glu Asn Leu Arg Lys Asn Leu Thr Arg Ala Thr Ala 
            500                 505                 510         


Arg Ala Pro Tyr Phe Ser Gly Ser Ser Thr Phe Ser Pro Thr Ile Leu 
        515                 520                 525             


Ser Ser Asp Lys Glu Thr Ile Glu Ile Ile Asp Leu Ala Lys Lys Asp 
    530                 535                 540                 


Leu Glu Lys Leu Lys Arg Lys Glu Lys Arg Lys Lys Lys Ser Val Ala 
545                 550                 555                 560 


Gly Lys Glu Asp Asn Thr Asp Thr Asp Gln Glu Lys Lys Glu Glu Lys 
                565                 570                 575     


Gly Val Ser Glu Arg Glu Asn Asn Glu Leu Glu Val Glu Glu Ser Gln 
            580                 585                 590         


Glu Val Ser Asp His Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        595                 600                 605             


Asp Asp Ile Asp Gly Gly Glu Ser Ser Asp Glu Ser Asp Ser Glu Ser 
    610                 615                 620                 


Asp Glu Lys Ala Asn Tyr Gln Ala Asp Leu Ala Asn Ile Thr Cys Glu 
625                 630                 635                 640 


Ile Ala Ile Lys Gln Lys Leu Ile Asp Glu Leu Glu Asn Ser Gln Lys 
                645                 650                 655     


Arg Leu Gln Thr Leu Lys Lys Gln Tyr Glu Glu Lys Leu Met Met Leu 
            660                 665                 670         


Gln His Lys Ile Arg Asp Thr Gln Leu Glu Arg Asp Gln Val Leu Gln 
        675                 680                 685             


Asn Leu Gly Ser Val Glu Ser Tyr Ser Glu Glu Lys Ala Lys Lys Val 
    690                 695                 700                 


Arg Ser Glu Tyr Glu Lys Lys Leu Gln Ala Met Asn Lys Glu Leu Gln 
705                 710                 715                 720 


Arg Leu Gln Ala Ala Gln Lys Glu His Ala Arg Leu Leu Lys Asn Gln 
                725                 730                 735     


Ser Gln Tyr Glu Lys Gln Leu Lys Lys Leu Gln Gln Asp Val Met Glu 
            740                 745                 750         


Met Lys Lys Thr Lys Val Arg Leu Met Lys Gln Met Lys Glu Glu Gln 
        755                 760                 765             


Glu Lys Ala Arg Leu Thr Glu Ser Arg Arg Asn Arg Glu Ile Ala Gln 
    770                 775                 780                 


Leu Lys Lys Asp Gln Arg Lys Arg Asp His Gln Leu Arg Leu Leu Glu 
785                 790                 795                 800 


Ala Gln Lys Arg Asn Gln Glu Val Val Leu Arg Arg Lys Thr Glu Glu 
                805                 810                 815     


Val Thr Ala Leu Arg Arg Gln Val Arg Pro Met Ser Asp Lys Val Ala 
            820                 825                 830         


Gly Lys Val Thr Arg Lys Leu Ser Ser Ser Asp Ala Pro Ala Gln Asp 
        835                 840                 845             


Thr Gly Ser Ser Ala Ala Ala Val Glu Thr Asp Ala Ser Arg Thr Gly 
    850                 855                 860                 


Ala Gln Gln Lys Met Arg Ile Pro Val Ala Arg Val Gln Ala Leu Pro 
865                 870                 875                 880 


Thr Pro Ala Thr Asn Gly Asn Arg Lys Lys Tyr Gln Arg Lys Gly Leu 
                885                 890                 895     


Thr Gly Arg Val Phe Ile Ser Lys Thr Ala Arg Met Lys Trp Gln Leu 
            900                 905                 910         


Leu Glu Arg Arg Val Thr Asp Ile Ile Met Gln Lys Met Thr Ile Ser 
        915                 920                 925             


Asn Met Glu Ala Asp Met Asn Arg Leu Leu Lys Gln Arg Glu Glu Leu 
    930                 935                 940                 


Thr Lys Arg Arg Glu Lys Leu Ser Lys Arg Arg Glu Lys Ile Val Lys 
945                 950                 955                 960 


Glu Asn Gly Glu Gly Asp Lys Asn Val Ala Asn Ile Asn Glu Glu Met 
                965                 970                 975     


Glu Ser Leu Thr Ala Asn Ile Asp Tyr Ile Asn Asp Ser Ile Ser Asp 
            980                 985                 990         


Cys Gln Ala Asn Ile Met Gln Met  Glu Glu Ala Lys Glu  Glu Gly Glu 
        995                 1000                 1005             


Thr Leu  Asp Val Thr Ala Val  Ile Asn Ala Cys Thr  Leu Thr Glu 
    1010                 1015                 1020             


Ala Arg  Tyr Leu Leu Asp His  Phe Leu Ser Met Gly  Ile Asn Lys 
    1025                 1030                 1035             


Gly Leu  Gln Ala Ala Gln Lys  Glu Ala Gln Ile Lys  Val Leu Glu 
    1040                 1045                 1050             


Gly Arg  Leu Lys Gln Thr Glu  Ile Thr Ser Ala Thr  Gln Asn Gln 
    1055                 1060                 1065             


Leu Leu  Phe His Met Leu Lys  Glu Lys Ala Glu Leu  Asn Pro Glu 
    1070                 1075                 1080             


Leu Asp  Ala Leu Leu Gly His  Ala Leu Gln Glu Asn  Val Glu Asp 
    1085                 1090                 1095             


Ser Thr  Asp Glu Asp Ala Pro  Leu Asn Ser Pro Gly  Ser Glu Gly 
    1100                 1105                 1110             


Ser Thr  Leu Ser Ser Asp Leu  Met Lys Leu Cys Gly  Glu Val Lys 
    1115                 1120                 1125             


Pro Lys  Asn Lys Ala Arg Arg  Arg Thr Thr Thr Gln  Met Glu Leu 
    1130                 1135                 1140             


Leu Tyr  Ala Asp Ser Ser Glu  Leu Ala Ser Asp Thr  Ser Thr Gly 
    1145                 1150                 1155             


Asp Ala  Ser Leu Pro Gly Pro  Leu Thr Pro Val Ala  Glu Gly Gln 
    1160                 1165                 1170             


Glu Ile  Gly Met Asn Thr Glu  Thr Ser Gly Thr Ser  Ala Arg Glu 
    1175                 1180                 1185             


Lys Glu  Leu Ser Pro Pro Pro  Gly Leu Pro Ser Lys  Ile Gly Ser 
    1190                 1195                 1200             


Ile Ser  Arg Gln Ser Ser Leu  Ser Glu Lys Lys Ile  Pro Glu Pro 
    1205                 1210                 1215             


Ser Pro  Val Thr Arg Arg Lys  Ala Tyr Glu Lys Ala  Glu Lys Ser 
    1220                 1225                 1230             


Lys Ala  Lys Glu Gln Lys His  Ser Asp Ser Gly Thr  Ser Glu Ala 
    1235                 1240                 1245             


Ser Leu  Ser Pro Pro Ser Ser  Pro Pro Ser Arg Pro  Arg Asn Glu 
    1250                 1255                 1260             


Leu Asn  Val Phe Asn Arg Leu  Thr Val Ser Gln Gly  Asn Thr Ser 
    1265                 1270                 1275             


Val Gln  Gln Asp Lys Gly Ile  Ile Asn Pro Phe Pro  Ala Ser Lys 
    1280                 1285                 1290             


Gly Ile  Arg Ala Phe Pro Leu  Gln Cys Ile His Ile  Ala Glu Gly 
    1295                 1300                 1305             


His Thr  Lys Ala Val Leu Cys  Val Asp Ser Thr Asp  Asp Leu Leu 
    1310                 1315                 1320             


Phe Thr  Gly Ser Lys Asp Arg  Thr Cys Lys Val Trp  Asn Leu Val 
    1325                 1330                 1335             


Thr Gly  Gln Glu Ile Met Ser  Leu Gly Gly His Pro  Asn Asn Val 
    1340                 1345                 1350             


Val Ser  Val Lys Tyr Cys Asn  Tyr Thr Ser Leu Val  Phe Thr Val 
    1355                 1360                 1365             


Ser Thr  Ser Tyr Ile Lys Val  Trp Asp Ile Arg Asp  Ser Ala Lys 
    1370                 1375                 1380             


Cys Ile  Arg Thr Leu Thr Ser  Ser Gly Gln Val Thr  Leu Gly Asp 
    1385                 1390                 1395             


Ala Cys  Ser Ala Ser Thr Ser  Arg Thr Val Ala Ile  Pro Ser Gly 
    1400                 1405                 1410             


Glu Asn  Gln Ile Asn Gln Ile  Ala Leu Asn Pro Thr  Gly Thr Phe 
    1415                 1420                 1425             


Leu Tyr  Ala Ala Ser Gly Asn  Ala Val Arg Met Trp  Asp Leu Lys 
    1430                 1435                 1440             


Arg Phe  Gln Ser Thr Gly Lys  Leu Thr Gly His Leu  Gly Pro Val 
    1445                 1450                 1455             


Met Cys  Leu Thr Val Asp Gln  Ile Ser Ser Gly Gln  Asp Leu Ile 
    1460                 1465                 1470             


Ile Thr  Gly Ser Lys Asp His  Tyr Ile Lys Met Phe  Asp Val Thr 
    1475                 1480                 1485             


Glu Gly  Ala Leu Gly Thr Val  Ser Pro Thr His Asn  Phe Glu Pro 
    1490                 1495                 1500             


Pro His  Tyr Asp Gly Ile Glu  Ala Leu Thr Ile Gln  Gly Asp Asn 
    1505                 1510                 1515             


Leu Phe  Ser Gly Ser Arg Asp  Asn Gly Ile Lys Lys  Trp Asp Leu 
    1520                 1525                 1530             


Thr Gln  Lys Asp Leu Leu Gln  Gln Val Pro Asn Ala  His Lys Asp 
    1535                 1540                 1545             


Trp Val  Cys Ala Leu Gly Val  Val Pro Asp His Pro  Val Leu Leu 
    1550                 1555                 1560             


Ser Gly  Cys Arg Gly Gly Ile  Leu Lys Val Trp Asn  Met Asp Thr 
    1565                 1570                 1575             


Phe Met  Pro Val Gly Glu Met  Lys Gly His Asp Ser  Pro Ile Asn 
    1580                 1585                 1590             


Ala Ile  Cys Val Asn Ser Thr  His Ile Phe Thr Ala  Ala Asp Asp 
    1595                 1600                 1605             


Arg Thr  Val Arg Ile Trp Lys  Ala Arg Asn Leu Gln  Asp Gly Gln 
    1610                 1615                 1620             


Ile Ser  Asp Thr Gly Asp Leu  Gly Glu Asp Ile Ala  Ser Asn 
    1625                 1630                 1635         


<210>  5880
<211>  1637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF21B__Homo_sapiens__NP_001239029

<400>  5880

Met Ala Gly Gln Gly Asp Cys Cys Val Lys Val Ala Val Arg Ile Arg 
1               5                   10                  15      


Pro Gln Leu Ser Lys Glu Lys Ile Glu Gly Cys His Ile Cys Thr Ser 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Gln Val Leu Leu Gly Lys Asp Lys Ala Phe 
        35                  40                  45              


Thr Tyr Asp Phe Val Phe Asp Leu Asp Thr Trp Gln Glu Gln Ile Tyr 
    50                  55                  60                  


Ser Thr Cys Val Ser Lys Leu Ile Glu Gly Cys Phe Glu Gly Tyr Asn 
65                  70                  75                  80  


Ala Thr Val Leu Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr Tyr Thr 
                85                  90                  95      


Met Gly Thr Gly Phe Asp Met Ala Thr Ser Glu Glu Glu Gln Gly Ile 
            100                 105                 110         


Ile Pro Arg Ala Ile Ala His Leu Phe Gly Gly Ile Ala Glu Arg Lys 
        115                 120                 125             


Arg Arg Ala Gln Glu Gln Gly Val Ala Gly Pro Glu Phe Lys Val Ser 
    130                 135                 140                 


Ala Gln Phe Leu Glu Leu Tyr Asn Glu Glu Ile Leu Asp Leu Phe Asp 
145                 150                 155                 160 


Ser Thr Arg Asp Pro Asp Thr Arg His Arg Arg Ser Asn Ile Lys Ile 
                165                 170                 175     


His Glu Asp Ala Asn Gly Gly Ile Tyr Thr Thr Gly Val Thr Ser Arg 
            180                 185                 190         


Leu Ile His Ser Gln Glu Glu Leu Ile Gln Cys Leu Lys Gln Gly Ala 
        195                 200                 205             


Leu Ser Arg Thr Thr Ala Ser Thr Gln Met Asn Val Gln Ser Ser Arg 
    210                 215                 220                 


Ser His Ala Ile Phe Thr Ile His Leu Cys Gln Met Arg Met Cys Thr 
225                 230                 235                 240 


Gln Pro Asp Leu Val Asn Glu Ala Val Thr Gly Leu Pro Asp Gly Thr 
                245                 250                 255     


Pro Pro Ser Ser Glu Tyr Glu Thr Leu Thr Ala Lys Phe His Phe Val 
            260                 265                 270         


Asp Leu Ala Gly Ser Glu Arg Leu Lys Arg Thr Gly Ala Thr Gly Glu 
        275                 280                 285             


Arg Ala Lys Glu Gly Ile Ser Ile Asn Cys Gly Leu Leu Ala Leu Gly 
    290                 295                 300                 


Asn Val Ile Ser Ala Leu Gly Asp Gln Ser Lys Lys Val Val His Val 
305                 310                 315                 320 


Pro Tyr Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly 
                325                 330                 335     


Gly Asn Ser Gln Thr Ile Met Ile Ala Cys Val Ser Pro Ser Asp Arg 
            340                 345                 350         


Asp Phe Met Glu Thr Leu Asn Thr Leu Lys Tyr Ala Asn Arg Ala Arg 
        355                 360                 365             


Asn Ile Lys Asn Lys Val Val Val Asn Gln Asp Lys Thr Ser Gln Gln 
    370                 375                 380                 


Ile Ser Ala Leu Arg Ala Glu Ile Ala Arg Leu Gln Met Glu Leu Met 
385                 390                 395                 400 


Glu Tyr Lys Ala Gly Lys Arg Val Ile Gly Glu Asp Gly Ala Glu Gly 
                405                 410                 415     


Tyr Ser Asp Leu Phe Arg Glu Asn Ala Met Leu Gln Lys Glu Asn Gly 
            420                 425                 430         


Ala Leu Arg Leu Arg Val Lys Ala Met Gln Glu Ala Ile Asp Ala Ile 
        435                 440                 445             


Asn Asn Arg Val Thr Gln Leu Met Ser Gln Glu Ala Asn Leu Leu Leu 
    450                 455                 460                 


Ala Lys Ala Gly Asp Gly Asn Glu Ala Ile Gly Ala Leu Ile Gln Asn 
465                 470                 475                 480 


Tyr Ile Arg Glu Ile Glu Glu Leu Arg Thr Lys Leu Leu Glu Ser Glu 
                485                 490                 495     


Ala Met Asn Glu Ser Leu Arg Arg Ser Leu Ser Arg Ala Ser Ala Arg 
            500                 505                 510         


Ser Pro Tyr Ser Leu Gly Ala Ser Pro Ala Ala Pro Ala Phe Gly Gly 
        515                 520                 525             


Ser Pro Ala Ser Ser Met Glu Asp Ala Ser Glu Val Ile Arg Arg Ala 
    530                 535                 540                 


Lys Gln Asp Leu Glu Arg Leu Lys Lys Lys Glu Val Arg Gln Arg Arg 
545                 550                 555                 560 


Lys Ser Pro Glu Lys Glu Ala Phe Lys Lys Arg Ala Lys Leu Gln Gln 
                565                 570                 575     


Glu Asn Ser Glu Glu Thr Asp Glu Asn Glu Ala Glu Glu Glu Glu Glu 
            580                 585                 590         


Glu Arg Asp Glu Ser Gly Cys Glu Glu Glu Glu Gly Arg Glu Asp Glu 
        595                 600                 605             


Asp Glu Asp Ser Gly Ser Glu Glu Ser Leu Val Asp Ser Asp Ser Asp 
    610                 615                 620                 


Pro Glu Glu Lys Glu Val Asn Phe Gln Ala Asp Leu Ala Asp Leu Thr 
625                 630                 635                 640 


Cys Glu Ile Glu Ile Lys Gln Lys Leu Ile Asp Glu Leu Glu Asn Ser 
                645                 650                 655     


Gln Arg Arg Leu Gln Thr Leu Lys His Gln Tyr Glu Glu Lys Leu Ile 
            660                 665                 670         


Leu Leu Gln Asn Lys Ile Arg Asp Thr Gln Leu Glu Arg Asp Arg Val 
        675                 680                 685             


Leu Gln Asn Leu Ser Thr Met Glu Cys Tyr Thr Glu Glu Lys Ala Asn 
    690                 695                 700                 


Lys Ile Lys Ala Asp Tyr Glu Lys Arg Leu Arg Glu Met Asn Arg Asp 
705                 710                 715                 720 


Leu Gln Lys Leu Gln Ala Ala Gln Lys Glu His Ala Arg Leu Leu Lys 
                725                 730                 735     


Asn Gln Ser Arg Tyr Glu Arg Glu Leu Lys Lys Leu Gln Ala Glu Val 
            740                 745                 750         


Ala Glu Met Lys Lys Ala Lys Val Ala Leu Met Lys Gln Met Arg Glu 
        755                 760                 765             


Glu Gln Gln Arg Arg Arg Leu Val Glu Thr Lys Arg Asn Arg Glu Ile 
    770                 775                 780                 


Ala Gln Leu Lys Lys Glu Gln Arg Arg Gln Glu Phe Gln Ile Arg Ala 
785                 790                 795                 800 


Leu Glu Ser Gln Lys Arg Gln Gln Glu Met Val Leu Arg Arg Lys Thr 
                805                 810                 815     


Gln Glu Val Ser Ala Leu Arg Arg Leu Ala Lys Pro Met Ser Glu Arg 
            820                 825                 830         


Val Ala Gly Arg Ala Gly Leu Lys Pro Pro Met Leu Asp Ser Gly Ala 
        835                 840                 845             


Glu Val Ser Ala Ser Thr Thr Ser Ser Glu Ala Glu Ser Gly Ala Arg 
    850                 855                 860                 


Ser Val Ser Ser Ile Val Arg Gln Trp Asn Arg Lys Ile Asn His Phe 
865                 870                 875                 880 


Leu Gly Asp His Pro Ala Pro Thr Val Asn Gly Thr Arg Pro Ala Arg 
                885                 890                 895     


Lys Lys Phe Gln Lys Lys Gly Ala Ser Gln Ser Phe Ser Lys Ala Ala 
            900                 905                 910         


Arg Leu Lys Trp Gln Ser Leu Glu Arg Arg Ile Ile Asp Ile Val Met 
        915                 920                 925             


Gln Arg Met Thr Ile Val Asn Leu Glu Ala Asp Met Glu Arg Leu Ile 
    930                 935                 940                 


Lys Lys Arg Glu Glu Leu Phe Leu Leu Gln Glu Ala Leu Arg Arg Lys 
945                 950                 955                 960 


Arg Glu Arg Leu Gln Ala Glu Ser Pro Glu Glu Glu Lys Gly Leu Gln 
                965                 970                 975     


Glu Leu Ala Glu Glu Ile Glu Val Leu Ala Ala Asn Ile Asp Tyr Ile 
            980                 985                 990         


Asn Asp Gly Ile Thr Asp Cys Gln  Ala Thr Ile Val Gln  Leu Glu Glu 
        995                 1000                 1005             


Thr Lys  Glu Glu Leu Asp Ser  Thr Asp Thr Ser Val  Val Ile Ser 
    1010                 1015                 1020             


Ser Cys  Ser Leu Ala Glu Ala  Arg Leu Leu Leu Asp  Asn Phe Leu 
    1025                 1030                 1035             


Lys Ala  Ser Ile Asp Lys Gly  Leu Gln Val Ala Gln  Lys Glu Ala 
    1040                 1045                 1050             


Gln Ile  Arg Leu Leu Glu Gly  Arg Leu Arg Gln Thr  Asp Met Ala 
    1055                 1060                 1065             


Gly Ser  Ser Gln Asn His Leu  Leu Leu Asp Ala Leu  Arg Glu Lys 
    1070                 1075                 1080             


Ala Glu  Ala His Pro Glu Leu  Gln Ala Leu Ile Tyr  Asn Val Gln 
    1085                 1090                 1095             


Gln Glu  Asn Gly Tyr Ala Ser  Thr Asp Glu Glu Ile  Ser Glu Phe 
    1100                 1105                 1110             


Ser Glu  Gly Ser Phe Ser Gln  Ser Phe Thr Met Lys  Gly Ser Thr 
    1115                 1120                 1125             


Ser His  Asp Asp Phe Lys Phe  Lys Ser Glu Pro Lys  Leu Ser Ala 
    1130                 1135                 1140             


Gln Met  Lys Ala Val Ser Ala  Glu Cys Leu Gly Pro  Pro Leu Asp 
    1145                 1150                 1155             


Ile Ser  Thr Lys Asn Ile Thr  Lys Ser Leu Ala Ser  Leu Val Glu 
    1160                 1165                 1170             


Ile Lys  Glu Asp Gly Val Gly  Phe Ser Val Arg Asp  Pro Tyr Tyr 
    1175                 1180                 1185             


Arg Asp  Arg Val Ser Arg Thr  Val Ser Leu Pro Thr  Arg Gly Ser 
    1190                 1195                 1200             


Thr Phe  Pro Arg Gln Ser Arg  Ala Thr Glu Thr Ser  Pro Leu Thr 
    1205                 1210                 1215             


Arg Arg  Lys Ser Tyr Asp Arg  Gly Gln Pro Ile Arg  Ser Thr Asp 
    1220                 1225                 1230             


Val Gly  Phe Thr Pro Pro Ser  Ser Pro Pro Thr Arg  Pro Arg Asn 
    1235                 1240                 1245             


Asp Arg  Asn Val Phe Ser Arg  Leu Thr Ser Asn Gln  Ser Gln Gly 
    1250                 1255                 1260             


Ser Ala  Leu Asp Lys Ser Asp  Asp Ser Asp Ser Ser  Leu Ser Glu 
    1265                 1270                 1275             


Val Leu  Arg Gly Ile Ile Ser  Pro Val Gly Gly Ala  Lys Gly Ala 
    1280                 1285                 1290             


Arg Thr  Ala Pro Leu Gln Cys  Val Ser Met Ala Glu  Gly His Thr 
    1295                 1300                 1305             


Lys Pro  Ile Leu Cys Leu Asp  Ala Thr Asp Glu Leu  Leu Phe Thr 
    1310                 1315                 1320             


Gly Ser  Lys Asp Arg Ser Cys  Lys Met Trp Asn Leu  Val Thr Gly 
    1325                 1330                 1335             


Gln Glu  Ile Ala Ala Leu Lys  Gly His Pro Asn Asn  Val Val Ser 
    1340                 1345                 1350             


Ile Lys  Tyr Cys Ser His Ser  Gly Leu Val Phe Ser  Val Ser Thr 
    1355                 1360                 1365             


Ser Tyr  Ile Lys Val Trp Asp  Ile Arg Asp Ser Ala  Lys Cys Ile 
    1370                 1375                 1380             


Arg Thr  Leu Thr Ser Ser Gly  Gln Val Ile Ser Gly  Asp Ala Cys 
    1385                 1390                 1395             


Ala Ala  Thr Ser Thr Arg Ala  Ile Thr Ser Ala Gln  Gly Glu His 
    1400                 1405                 1410             


Gln Ile  Asn Gln Ile Ala Leu  Ser Pro Ser Gly Thr  Met Leu Tyr 
    1415                 1420                 1425             


Ala Ala  Ser Gly Asn Ala Val  Arg Ile Trp Glu Leu  Ser Arg Phe 
    1430                 1435                 1440             


Gln Pro  Val Gly Lys Leu Thr  Gly His Ile Gly Pro  Val Met Cys 
    1445                 1450                 1455             


Leu Thr  Val Thr Gln Thr Ala  Ser Gln His Asp Leu  Val Val Thr 
    1460                 1465                 1470             


Gly Ser  Lys Asp His Tyr Val  Lys Met Phe Glu Leu  Gly Glu Cys 
    1475                 1480                 1485             


Val Thr  Gly Thr Ile Gly Pro  Thr His Asn Phe Glu  Pro Pro His 
    1490                 1495                 1500             


Tyr Asp  Gly Ile Glu Cys Leu  Ala Ile Gln Gly Asp  Ile Leu Phe 
    1505                 1510                 1515             


Ser Gly  Ser Arg Asp Asn Gly  Ile Lys Lys Trp Asp  Leu Asp Gln 
    1520                 1525                 1530             


Gln Glu  Leu Ile Gln Gln Ile  Pro Asn Ala His Lys  Asp Trp Val 
    1535                 1540                 1545             


Cys Ala  Leu Ala Phe Ile Pro  Gly Arg Pro Met Leu  Leu Ser Ala 
    1550                 1555                 1560             


Cys Arg  Ala Gly Val Ile Lys  Val Trp Asn Val Asp  Asn Phe Thr 
    1565                 1570                 1575             


Pro Ile  Gly Glu Ile Lys Gly  His Asp Ser Pro Ile  Asn Ala Ile 
    1580                 1585                 1590             


Cys Thr  Asn Ala Lys His Ile  Phe Thr Ala Ser Ser  Asp Cys Arg 
    1595                 1600                 1605             


Val Lys  Leu Trp Asn Tyr Val  Pro Gly Leu Thr Pro  Cys Leu Pro 
    1610                 1615                 1620             


Arg Arg  Val Leu Ala Ile Lys  Gly Arg Ala Thr Thr  Leu Pro 
    1625                 1630                 1635         


<210>  5881
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF22__Homo_sapiens__NP_001243199

<400>  5881

Met Asp Ser Cys Ser Leu Glu Ile Ala Asn Trp Arg Asn His Gln Glu 
1               5                   10                  15      


Thr Leu Lys Tyr Gln Phe Asp Ala Phe Tyr Gly Glu Arg Ser Thr Gln 
            20                  25                  30          


Gln Asp Ile Tyr Ala Gly Ser Val Gln Pro Ile Leu Arg His Leu Leu 
        35                  40                  45              


Glu Gly Gln Asn Ala Ser Val Leu Ala Tyr Gly Pro Thr Gly Ala Gly 
    50                  55                  60                  


Lys Thr His Thr Met Leu Gly Ser Pro Glu Gln Pro Gly Val Ile Pro 
65                  70                  75                  80  


Arg Ala Leu Met Asp Leu Leu Gln Leu Thr Arg Glu Glu Gly Ala Glu 
                85                  90                  95      


Gly Arg Pro Trp Ala Leu Ser Val Thr Met Ser Tyr Leu Glu Ile Tyr 
            100                 105                 110         


Gln Glu Lys Val Leu Asp Leu Leu Asp Pro Ala Ser Gly Asp Leu Val 
        115                 120                 125             


Ile Arg Glu Asp Cys Arg Gly Asn Ile Leu Ile Pro Gly Leu Ser Gln 
    130                 135                 140                 


Lys Pro Ile Ser Ser Phe Ala Asp Phe Glu Arg His Phe Leu Pro Ala 
145                 150                 155                 160 


Ser Arg Asn Arg Thr Val Gly Ala Thr Arg Leu Asn Gln Arg Ser Ser 
                165                 170                 175     


Arg Ser His Ala Val Leu Leu Val Lys Val Asp Gln Arg Glu Arg Leu 
            180                 185                 190         


Ala Pro Phe Arg Gln Arg Glu Gly Lys Leu Tyr Leu Ile Asp Leu Ala 
        195                 200                 205             


Gly Ser Glu Asp Asn Arg Arg Thr Gly Asn Lys Gly Leu Arg Leu Lys 
    210                 215                 220                 


Glu Ser Gly Ala Ile Asn Thr Ser Leu Phe Val Leu Gly Lys Val Val 
225                 230                 235                 240 


Asp Ala Leu Asn Gln Gly Leu Pro Arg Val Pro Tyr Arg Asp Ser Lys 
                245                 250                 255     


Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Ser Ala His Ser Ile 
            260                 265                 270         


Leu Ile Ala Asn Ile Ala Pro Glu Arg Arg Phe Tyr Leu Asp Thr Val 
        275                 280                 285             


Ser Ala Leu Asn Phe Ala Ala Arg Ser Lys Glu Val Ile Asn Arg Pro 
    290                 295                 300                 


Phe Thr Asn Glu Ser Leu Gln Pro His Ala Leu Gly Pro Val Lys Leu 
305                 310                 315                 320 


Ser Gln Lys Glu Leu Leu Gly Pro Pro Glu Ala Lys Arg Ala Arg Gly 
                325                 330                 335     


Pro Glu Glu Glu Glu Ile Gly Ser Pro Glu Pro Met Ala Ala Pro Ala 
            340                 345                 350         


Ser Ala Ser Gln Lys Leu Ser Pro Leu Gln Lys Leu Ser Ser Met Asp 
        355                 360                 365             


Pro Ala Met Leu Glu Arg Leu Leu Ser Leu Asp Arg Leu Leu Ala Ser 
    370                 375                 380                 


Gln Gly Ser Gln Gly Ala Pro Leu Leu Ser Thr Pro Lys Arg Glu Arg 
385                 390                 395                 400 


Met Val Leu Met Lys Thr Val Glu Glu Lys Asp Leu Glu Ile Glu Arg 
                405                 410                 415     


Leu Lys Thr Lys Gln Lys Glu Leu Glu Ala Lys Met Leu Ala Gln Lys 
            420                 425                 430         


Ala Glu Glu Lys Glu Asn His Cys Pro Thr Met Leu Arg Pro Leu Ser 
        435                 440                 445             


His Arg Thr Val Thr Gly Ala Lys Pro Leu Lys Lys Ala Val Val Met 
    450                 455                 460                 


Pro Leu Gln Leu Ile Gln Glu Gln Ala Ala Ser Pro Asn Ala Glu Ile 
465                 470                 475                 480 


His Ile Leu Lys Asn Lys Gly Arg Lys Arg Lys Leu Glu Ser Leu Asp 
                485                 490                 495     


Ala Leu Glu Pro Glu Glu Lys Ala Glu Asp Cys Trp Glu Leu Gln Ile 
            500                 505                 510         


Ser Pro Glu Leu Leu Ala His Gly Arg Gln Lys Ile Leu Asp Leu Leu 
        515                 520                 525             


Asn Glu Gly Ser Ala Arg Asp Leu Arg Ser Leu Gln Arg Ile Gly Pro 
    530                 535                 540                 


Lys Lys Ala Gln Leu Ile Val Gly Trp Arg Glu Leu His Gly Pro Phe 
545                 550                 555                 560 


Ser Gln Val Glu Asp Leu Glu Arg Val Glu Gly Ile Thr Gly Lys Gln 
                565                 570                 575     


Met Glu Ser Phe Leu Lys Ala Asn Ile Leu Gly Leu Ala Ala Gly Gln 
            580                 585                 590         


Arg Cys Gly Ala Ser 
        595         


<210>  5882
<211>  856
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF23__Homo_sapiens__NP_004847

<400>  5882

Met Lys Ser Ala Arg Ala Lys Thr Pro Arg Lys Pro Thr Val Lys Lys 
1               5                   10                  15      


Gly Ser Gln Thr Asn Leu Lys Asp Pro Val Gly Val Tyr Cys Arg Val 
            20                  25                  30          


Arg Pro Leu Gly Phe Pro Asp Gln Glu Cys Cys Ile Glu Val Ile Asn 
        35                  40                  45              


Asn Thr Thr Val Gln Leu His Thr Pro Glu Gly Tyr Arg Leu Asn Arg 
    50                  55                  60                  


Asn Gly Asp Tyr Lys Glu Thr Gln Tyr Ser Phe Lys Gln Val Phe Gly 
65                  70                  75                  80  


Thr His Thr Thr Gln Lys Glu Leu Phe Asp Val Val Ala Asn Pro Leu 
                85                  90                  95      


Val Asn Asp Leu Ile His Gly Lys Asn Gly Leu Leu Phe Thr Tyr Gly 
            100                 105                 110         


Val Thr Gly Ser Gly Lys Thr His Thr Met Thr Gly Ser Pro Gly Glu 
        115                 120                 125             


Gly Gly Leu Leu Pro Arg Cys Leu Asp Met Ile Phe Asn Ser Ile Gly 
    130                 135                 140                 


Ser Phe Gln Ala Lys Arg Tyr Val Phe Lys Ser Asn Asp Arg Asn Ser 
145                 150                 155                 160 


Met Asp Ile Gln Cys Glu Val Asp Ala Leu Leu Glu Arg Gln Lys Arg 
                165                 170                 175     


Glu Ala Met Pro Asn Pro Lys Thr Ser Ser Ser Lys Arg Gln Val Asp 
            180                 185                 190         


Pro Glu Phe Ala Asp Met Ile Thr Val Gln Glu Phe Cys Lys Ala Glu 
        195                 200                 205             


Glu Val Asp Glu Asp Ser Val Tyr Gly Val Phe Val Ser Tyr Ile Glu 
    210                 215                 220                 


Ile Tyr Asn Asn Tyr Ile Tyr Asp Leu Leu Glu Glu Val Pro Phe Asp 
225                 230                 235                 240 


Pro Ile Lys Pro Lys Pro Pro Gln Ser Lys Leu Leu Arg Glu Asp Lys 
                245                 250                 255     


Asn His Asn Met Tyr Val Ala Gly Cys Thr Glu Val Glu Val Lys Ser 
            260                 265                 270         


Thr Glu Glu Ala Phe Glu Val Phe Trp Arg Gly Gln Lys Lys Arg Arg 
        275                 280                 285             


Ile Ala Asn Thr His Leu Asn Arg Glu Ser Ser Arg Ser His Ser Val 
    290                 295                 300                 


Phe Asn Ile Lys Leu Val Gln Ala Pro Leu Asp Ala Asp Gly Asp Asn 
305                 310                 315                 320 


Val Leu Gln Glu Lys Glu Gln Ile Thr Ile Ser Gln Leu Ser Leu Val 
                325                 330                 335     


Asp Leu Ala Gly Ser Glu Arg Thr Asn Arg Thr Arg Ala Glu Gly Asn 
            340                 345                 350         


Arg Leu Arg Glu Ala Gly Asn Ile Asn Gln Ser Leu Met Thr Leu Arg 
        355                 360                 365             


Thr Cys Met Asp Val Leu Arg Glu Asn Gln Met Tyr Gly Thr Asn Lys 
    370                 375                 380                 


Met Val Pro Tyr Arg Asp Ser Lys Leu Thr His Leu Phe Lys Asn Tyr 
385                 390                 395                 400 


Phe Asp Gly Glu Gly Lys Val Arg Met Ile Val Cys Val Asn Pro Lys 
                405                 410                 415     


Ala Glu Asp Tyr Glu Glu Asn Leu Gln Val Met Arg Phe Ala Glu Val 
            420                 425                 430         


Thr Gln Glu Val Glu Val Ala Arg Pro Val Asp Lys Ala Ile Cys Gly 
        435                 440                 445             


Leu Thr Pro Gly Arg Arg Tyr Arg Asn Gln Pro Arg Gly Pro Val Gly 
    450                 455                 460                 


Asn Glu Pro Leu Val Thr Asp Val Val Leu Gln Ser Phe Pro Pro Leu 
465                 470                 475                 480 


Pro Ser Cys Glu Ile Leu Asp Ile Asn Asp Glu Gln Thr Leu Pro Arg 
                485                 490                 495     


Leu Ile Glu Ala Leu Glu Lys Arg His Asn Leu Arg Gln Met Met Ile 
            500                 505                 510         


Asp Glu Phe Asn Lys Gln Ser Asn Ala Phe Lys Ala Leu Leu Gln Glu 
        515                 520                 525             


Phe Asp Asn Ala Val Leu Ser Lys Glu Asn His Met Gln Gly Lys Leu 
    530                 535                 540                 


Asn Glu Lys Glu Lys Met Ile Ser Gly Gln Lys Leu Glu Ile Glu Arg 
545                 550                 555                 560 


Leu Glu Lys Lys Asn Lys Thr Leu Glu Tyr Lys Ile Glu Ile Leu Glu 
                565                 570                 575     


Lys Thr Thr Thr Ile Tyr Glu Glu Asp Lys Arg Asn Leu Gln Gln Glu 
            580                 585                 590         


Leu Glu Thr Gln Asn Gln Lys Leu Gln Arg Gln Phe Ser Asp Lys Arg 
        595                 600                 605             


Arg Leu Glu Ala Arg Leu Gln Gly Met Val Thr Glu Thr Thr Met Lys 
    610                 615                 620                 


Trp Glu Lys Glu Cys Glu Arg Arg Val Ala Ala Lys Gln Leu Glu Met 
625                 630                 635                 640 


Gln Asn Lys Leu Trp Val Lys Asp Glu Lys Leu Lys Gln Leu Lys Ala 
                645                 650                 655     


Ile Val Thr Glu Pro Lys Thr Glu Lys Pro Glu Arg Pro Ser Arg Glu 
            660                 665                 670         


Arg Asp Arg Glu Lys Val Thr Gln Arg Ser Val Ser Pro Ser Pro Val 
        675                 680                 685             


Pro Leu Leu Phe Gln Pro Asp Gln Asn Ala Pro Pro Ile Arg Leu Arg 
    690                 695                 700                 


His Arg Arg Ser Arg Ser Ala Gly Asp Arg Trp Val Asp His Lys Pro 
705                 710                 715                 720 


Ala Ser Asn Met Gln Thr Glu Thr Val Met Gln Pro His Val Pro His 
                725                 730                 735     


Ala Ile Thr Val Ser Val Ala Asn Glu Lys Ala Leu Ala Lys Cys Glu 
            740                 745                 750         


Lys Tyr Met Leu Thr His Gln Glu Leu Ala Ser Asp Gly Glu Ile Glu 
        755                 760                 765             


Thr Lys Leu Ile Lys Gly Asp Ile Tyr Lys Thr Arg Gly Gly Gly Gln 
    770                 775                 780                 


Ser Val Gln Phe Thr Asp Ile Glu Thr Leu Lys Gln Glu Ser Pro Asn 
785                 790                 795                 800 


Gly Ser Arg Lys Arg Arg Ser Ser Thr Val Ala Pro Ala Gln Pro Asp 
                805                 810                 815     


Gly Ala Glu Ser Glu Trp Thr Asp Val Glu Thr Arg Cys Ser Val Ala 
            820                 825                 830         


Val Glu Met Arg Ala Gly Ser Gln Leu Gly Pro Gly Tyr Gln His His 
        835                 840                 845             


Ala Gln Pro Lys Arg Lys Lys Pro 
    850                 855     


<210>  5883
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF24__Homo_sapiens__NP_919289

<400>  5883

Met Ala Ser Trp Leu Tyr Glu Cys Leu Cys Glu Ala Glu Leu Ala Gln 
1               5                   10                  15      


Tyr Tyr Ser His Phe Thr Ala Leu Gly Leu Gln Lys Ile Asp Glu Leu 
            20                  25                  30          


Ala Lys Ile Thr Met Lys Asp Tyr Ser Lys Leu Gly Val His Asp Met 
        35                  40                  45              


Asn Asp Arg Lys Arg Leu Phe Gln Leu Ile Lys Ile Ile Lys Ile Met 
    50                  55                  60                  


Gln Glu Glu Asp Lys Ala Val Ser Ile Pro Glu Arg His Leu Gln Thr 
65                  70                  75                  80  


Ser Ser Leu Arg Ile Lys Ser Gln Glu Leu Arg Ser Gly Pro Arg Arg 
                85                  90                  95      


Gln Leu Asn Phe Asp Ser Pro Ala Asp Asn Lys Asp Arg Asn Ala Ser 
            100                 105                 110         


Asn Asp Gly Phe Glu Met Cys Ser Leu Ser Asp Phe Ser Ala Asn Glu 
        115                 120                 125             


Gln Lys Ser Thr Tyr Leu Lys Val Leu Glu His Met Leu Pro Asp Asp 
    130                 135                 140                 


Ser Gln Tyr His Thr Lys Thr Gly Ile Leu Asn Ala Thr Ala Gly Asp 
145                 150                 155                 160 


Ser Tyr Val Gln Thr Glu Ile Ser Thr Ser Leu Phe Ser Pro Asn Tyr 
                165                 170                 175     


Leu Ser Ala Ile Leu Gly Asp Cys Asp Ile Pro Ile Ile Gln Arg Ile 
            180                 185                 190         


Ser His Val Ser Gly Tyr Asn Tyr Gly Ile Pro His Ser Cys Ile Arg 
        195                 200                 205             


Gln Asn Thr Ser Glu Lys Gln Asn Pro Trp Thr Glu Met Glu Lys Ile 
    210                 215                 220                 


Arg Val Cys Val Arg Lys Arg Pro Leu Gly Met Arg Glu Val Arg Arg 
225                 230                 235                 240 


Gly Glu Ile Asn Ile Ile Thr Val Glu Asp Lys Glu Thr Leu Leu Val 
                245                 250                 255     


His Glu Lys Lys Glu Ala Val Asp Leu Thr Gln Tyr Ile Leu Gln His 
            260                 265                 270         


Val Phe Tyr Phe Asp Glu Val Phe Gly Glu Ala Cys Thr Asn Gln Asp 
        275                 280                 285             


Val Tyr Met Lys Thr Thr His Pro Leu Ile Gln His Ile Phe Asn Gly 
    290                 295                 300                 


Gly Asn Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr 
305                 310                 315                 320 


Tyr Thr Met Ile Gly Thr His Glu Asn Pro Gly Leu Tyr Ala Leu Ala 
                325                 330                 335     


Ala Lys Asp Ile Phe Arg Gln Leu Glu Val Ser Gln Pro Arg Lys His 
            340                 345                 350         


Leu Phe Val Trp Ile Ser Phe Tyr Glu Ile Tyr Cys Gly Gln Leu Tyr 
        355                 360                 365             


Asp Leu Leu Asn Arg Arg Lys Arg Leu Phe Ala Arg Glu Asp Ser Lys 
    370                 375                 380                 


His Met Val Gln Ile Val Gly Leu Gln Glu Leu Gln Val Asp Ser Val 
385                 390                 395                 400 


Glu Leu Leu Leu Glu Val Ile Leu Lys Gly Ser Lys Glu Arg Ser Thr 
                405                 410                 415     


Gly Ala Thr Gly Val Asn Ala Asp Ser Ser Arg Ser His Ala Val Ile 
            420                 425                 430         


Gln Ile Gln Ile Lys Asp Ser Ala Lys Arg Thr Phe Gly Arg Ile Ser 
        435                 440                 445             


Phe Ile Asp Leu Ala Gly Ser Glu Arg Ala Ala Asp Ala Arg Asp Ser 
    450                 455                 460                 


Asp Arg Gln Thr Lys Met Glu Gly Ala Glu Ile Asn Gln Ser Leu Leu 
465                 470                 475                 480 


Ala Leu Lys Glu Cys Ile Arg Ala Leu Asp Gln Glu His Thr His Thr 
                485                 490                 495     


Pro Phe Arg Gln Ser Lys Leu Thr Gln Val Leu Lys Asp Ser Phe Ile 
            500                 505                 510         


Gly Asn Ala Lys Thr Cys Met Ile Ala Asn Ile Ser Pro Ser His Val 
        515                 520                 525             


Ala Thr Glu His Thr Leu Asn Thr Leu Arg Tyr Ala Asp Arg Val Lys 
    530                 535                 540                 


Glu Leu Lys Lys Gly Ile Lys Cys Cys Thr Ser Val Thr Ser Arg Asn 
545                 550                 555                 560 


Arg Thr Ser Gly Asn Ser Ser Pro Lys Arg Ile Gln Ser Ser Pro Gly 
                565                 570                 575     


Ala Leu Ser Glu Asp Lys Cys Ser Pro Lys Lys Val Lys Leu Gly Phe 
            580                 585                 590         


Gln Gln Ser Leu Thr Val Ala Ala Pro Gly Ser Thr Arg Gly Lys Val 
        595                 600                 605             


His Pro Leu Thr Ser His Pro Pro Asn Ile Pro Phe Thr Ser Ala Pro 
    610                 615                 620                 


Lys Val Ser Gly Lys Arg Gly Gly Ser Arg Gly Ser Pro Ser Gln Glu 
625                 630                 635                 640 


Trp Val Ile His Ala Ser Pro Val Lys Gly Thr Val Arg Ser Gly His 
                645                 650                 655     


Val Ala Lys Lys Lys Pro Glu Glu Ser Ala Pro Leu Cys Ser Glu Lys 
            660                 665                 670         


Asn Arg Met Gly Asn Lys Thr Val Leu Gly Trp Glu Ser Arg Ala Ser 
        675                 680                 685             


Gly Pro Gly Glu Gly Leu Val Arg Gly Lys Leu Ser Thr Lys Cys Lys 
    690                 695                 700                 


Lys Val Gln Thr Val Gln Pro Val Gln Lys Gln Leu Val Ser Arg Val 
705                 710                 715                 720 


Glu Leu Ser Phe Gly Asn Ala His His Arg Ala Glu Tyr Ser Gln Asp 
                725                 730                 735     


Ser Gln Arg Gly Thr Pro Ala Arg Pro Ala Ser Glu Ala Trp Thr Asn 
            740                 745                 750         


Ile Pro Pro His Gln Lys Glu Arg Glu Glu His Leu Arg Phe Tyr His 
        755                 760                 765             


Gln Gln Phe Gln Gln Pro Pro Leu Leu Gln Gln Lys Leu Lys Tyr Gln 
    770                 775                 780                 


Pro Leu Lys Arg Ser Leu Arg Gln Tyr Arg Pro Pro Glu Gly Gln Leu 
785                 790                 795                 800 


Thr Asn Glu Thr Pro Pro Leu Phe His Ser Tyr Ser Glu Asn His Asp 
                805                 810                 815     


Gly Ala Gln Val Glu Glu Leu Asp Asp Ser Asp Phe Ser Glu Asp Ser 
            820                 825                 830         


Phe Ser His Ile Ser Ser Gln Arg Ala Thr Lys Gln Arg Asn Thr Leu 
        835                 840                 845             


Glu Asn Ser Glu Asp Ser Phe Phe Leu His Gln Thr Trp Gly Gln Gly 
    850                 855                 860                 


Pro Glu Lys Gln Val Ala Glu Arg Gln Gln Ser Leu Phe Ser Ser Pro 
865                 870                 875                 880 


Arg Thr Gly Asp Lys Lys Asp Leu Thr Lys Ser Trp Val Asp Ser Arg 
                885                 890                 895     


Asp Pro Ile Asn His Arg Arg Ala Ala Leu Asp His Ser Cys Ser Pro 
            900                 905                 910         


Ser Lys Gly Pro Val Asp Trp Ser Arg Glu Asn Ser Thr Ser Ser Gly 
        915                 920                 925             


Pro Ser Pro Arg Asp Ser Leu Ala Glu Lys Pro Tyr Cys Ser Gln Val 
    930                 935                 940                 


Asp Phe Ile Tyr Arg Gln Glu Arg Gly Gly Gly Ser Ser Phe Asp Leu 
945                 950                 955                 960 


Arg Lys Asp Ala Ser Gln Ser Glu Val Ser Gly Glu Asn Glu Gly Asn 
                965                 970                 975     


Leu Pro Ser Pro Glu Glu Asp Gly Phe Thr Ile Ser Leu Ser His Val 
            980                 985                 990         


Ala Val Pro Gly Ser Pro Asp Gln  Arg Asp Thr Val Thr  Thr Pro Leu 
        995                 1000                 1005             


Arg Glu  Val Ser Ala Asp Gly  Pro Ile Gln Val Thr  Ser Thr Val 
    1010                 1015                 1020             


Lys Asn  Gly His Ala Val Pro  Gly Glu Asp Pro Arg  Gly Gln Leu 
    1025                 1030                 1035             


Gly Thr  His Ala Glu Tyr Ala  Ser Gly Leu Met Ser  Pro Leu Thr 
    1040                 1045                 1050             


Met Ser  Leu Leu Glu Asn Pro  Asp Asn Glu Gly Ser  Pro Pro Ser 
    1055                 1060                 1065             


Glu Gln  Leu Val Gln Asp Gly  Ala Thr His Ser Leu  Val Ala Glu 
    1070                 1075                 1080             


Ser Thr  Gly Gly Pro Val Val  Ser His Thr Val Pro  Ser Gly Asp 
    1085                 1090                 1095             


Gln Glu  Ala Ala Leu Pro Val  Ser Ser Ala Thr Arg  His Leu Trp 
    1100                 1105                 1110             


Leu Ser  Ser Ser Pro Pro Asp  Asn Lys Pro Gly Gly  Asp Leu Pro 
    1115                 1120                 1125             


Ala Leu  Ser Pro Ser Pro Ile  Arg Gln His Pro Ala  Asp Lys Leu 
    1130                 1135                 1140             


Pro Ser  Arg Glu Ala Asp Leu  Gly Glu Ala Cys Gln  Ser Arg Glu 
    1145                 1150                 1155             


Thr Val  Leu Phe Ser His Glu  His Met Gly Ser Glu  Gln Tyr Asp 
    1160                 1165                 1170             


Ala Asp  Ala Glu Glu Thr Gly  Leu Asp Gly Ser Trp  Gly Phe Pro 
    1175                 1180                 1185             


Gly Lys  Pro Phe Thr Thr Ile  His Met Gly Val Pro  His Ser Gly 
    1190                 1195                 1200             


Pro Thr  Leu Thr Pro Arg Thr  Gly Ser Ser Asp Val  Ala Asp Gln 
    1205                 1210                 1215             


Leu Trp  Ala Gln Glu Arg Lys  His Pro Thr Arg Leu  Gly Trp Gln 
    1220                 1225                 1230             


Glu Phe  Gly Leu Ser Thr Asp  Pro Ile Lys Leu Pro  Cys Asn Ser 
    1235                 1240                 1245             


Glu Asn  Val Thr Trp Leu Lys  Pro Arg Pro Ile Ser  Arg Cys Leu 
    1250                 1255                 1260             


Ala Arg  Pro Ser Ser Pro Leu  Val Pro Ser Cys Ser  Pro Lys Thr 
    1265                 1270                 1275             


Ala Gly  Thr Leu Arg Gln Pro  Thr Leu Glu Gln Ala  Gln Gln Val 
    1280                 1285                 1290             


Val Ile  Arg Ala His Gln Glu  Gln Leu Asp Glu Met  Ala Glu Leu 
    1295                 1300                 1305             


Gly Phe  Lys Glu Glu Thr Leu  Met Ser Gln Leu Ala  Ser Asn Asp 
    1310                 1315                 1320             


Phe Glu  Asp Phe Val Thr Gln  Leu Asp Glu Ile Met  Val Leu Lys 
    1325                 1330                 1335             


Ser Lys  Cys Ile Gln Ser Leu  Arg Ser Gln Leu Gln  Leu Tyr Leu 
    1340                 1345                 1350             


Thr Cys  His Gly Pro Thr Ala  Ala Pro Glu Gly Thr  Val Pro Ser 
    1355                 1360                 1365             


<210>  5884
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF25__Homo_sapiens__NP_005346

<400>  5884

Met Thr Trp Thr Ser Gly Gln Leu Gln Arg Glu Lys Gln Ala Arg Pro 
1               5                   10                  15      


Gly Ser Gly Ala Val Leu Ala Phe Pro Asp Asp Lys Asp Leu Arg Val 
            20                  25                  30          


Tyr Gly Pro Ala Glu Ser Gln Ser Ala Val Phe Gly Asp Val Cys Pro 
        35                  40                  45              


Leu Leu Thr Ser Leu Leu Asp Gly Tyr Asn Val Cys Val Met Ala Tyr 
    50                  55                  60                  


Gly Gln Thr Gly Ser Gly Lys Ser Tyr Thr Met Leu Gly Arg His Ser 
65                  70                  75                  80  


Asp Asp Gly Pro Val Leu Pro Leu Asp Pro Gln Ser Asp Leu Gly Ile 
                85                  90                  95      


Ile Pro Arg Val Ala Glu Glu Leu Phe Arg Leu Ile Leu Glu Asn Thr 
            100                 105                 110         


Ser Arg Ser Pro Lys Val Glu Val Ser Ile Val Glu Val Tyr Asn Asn 
        115                 120                 125             


Asp Ile Phe Asp Leu Leu Ala Lys Asp Ser Ile Ala Ala Val Ser Gly 
    130                 135                 140                 


Val Lys Arg Glu Val Val Thr Ala Lys Asp Gly Arg Thr Glu Val Ala 
145                 150                 155                 160 


Leu Leu Ala Ser Glu Ala Val Gly Ser Ala Ser Lys Leu Met Glu Leu 
                165                 170                 175     


Val His Gly Gly Leu Gln Leu Arg Ala Lys His Pro Thr Leu Val His 
            180                 185                 190         


Ala Asp Ser Ser Arg Ser His Leu Ile Ile Thr Val Thr Leu Thr Thr 
        195                 200                 205             


Ala Ser Cys Ser Asp Ser Thr Ala Asp Gln Ala Cys Ser Ala Thr Leu 
    210                 215                 220                 


Pro Arg Glu Gln Thr Glu Ala Gly Arg Ala Gly Arg Ser Arg Arg Ala 
225                 230                 235                 240 


Ser Gln Gly Ala Leu Ala Pro Gln Leu Val Pro Gly Asn Pro Ala Gly 
                245                 250                 255     


His Ala Glu Gln Val Gln Ala Arg Leu Gln Leu Val Asp Ser Ala Gly 
            260                 265                 270         


Ser Glu Cys Val Gly Gly Asp Ala Lys Leu Leu Val Ile Leu Cys Ile 
        275                 280                 285             


Ser Pro Ser Gln Arg His Leu Ala Gln Thr Leu Gln Gly Leu Gly Phe 
    290                 295                 300                 


Gly Ile Arg Ala Arg Gln Val Gln Arg Gly Pro Ala Arg Lys Lys Pro 
305                 310                 315                 320 


Pro Ser Ser Gln Thr Glu Gly Lys Arg Arg Pro Asp 
                325                 330         


<210>  5885
<211>  1882
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF26A__Homo_sapiens__NP_056471

<400>  5885

Met Val Gly Arg Gly Val Pro Leu Cys Ala Ala Gln Pro Ala Val Ala 
1               5                   10                  15      


Glu Gly Gly Pro Ala Arg Glu Pro Pro Pro Leu Leu Glu Val Ser Pro 
            20                  25                  30          


Arg Lys Arg Leu Pro Ala Gly Pro Asp Gln Asp Pro Cys Gly Ser Arg 
        35                  40                  45              


Pro Ala Pro Glu Gly Ala Gly Ala Gly Pro Glu Gln Gly His Ser Ala 
    50                  55                  60                  


Gly Gly Gly Gly Trp Cys Arg His Cys His Thr Lys Leu Val Glu Leu 
65                  70                  75                  80  


Lys Arg Gln Ala Trp Lys Leu Val Ser Gly Pro Gly Thr Thr Leu Arg 
                85                  90                  95      


Asp Pro Cys Leu Ser Ala Leu Leu Leu Asp Lys Leu Pro Ala Pro Gly 
            100                 105                 110         


Ala Leu Pro Ala Cys Arg Pro Glu Ala Glu Arg Arg Cys Asp Val Cys 
        115                 120                 125             


Ala Thr His Leu Gln Gln Leu Thr Arg Glu Ala Met His Leu Leu Gln 
    130                 135                 140                 


Ala Pro Ala Ser His Glu Asp Leu Asp Ala Pro His Gly Gly Pro Ser 
145                 150                 155                 160 


Leu Ala Pro Pro Ser Thr Thr Thr Ser Ser Arg Asp Thr Pro Gly Pro 
                165                 170                 175     


Ala Gly Pro Ala Gly Arg Gln Pro Gly Arg Ala Gly Pro Asp Arg Thr 
            180                 185                 190         


Lys Gly Leu Ala Trp Ser Pro Gly Pro Ser Val Gln Val Ser Val Ala 
        195                 200                 205             


Pro Ala Gly Leu Gly Gly Ala Leu Ser Thr Val Thr Ile Gln Ala Gln 
    210                 215                 220                 


Gln Cys Leu Glu Gly Met Trp Ser Val Ser Arg Val Asn Ser Phe Leu 
225                 230                 235                 240 


Pro Pro Ala Cys Leu Ala Glu Ala Ala Val Ala Ala Val Ala Val Ala 
                245                 250                 255     


Asp Thr Val Arg Glu Cys Pro Pro Val Ala Gly Pro Asp Gly Leu Ser 
            260                 265                 270         


Lys Ala Trp Gly Arg Gly Gly Val Cys Thr Ser Ala Leu Val Thr Pro 
        275                 280                 285             


Thr Pro Gly Ser Val Gly Gly Ser Thr Gly Pro Ser Ala Ala Ala Ser 
    290                 295                 300                 


Phe Phe Ile Arg Ala Met Gln Lys Leu Ser Leu Ala Ser Lys Arg Lys 
305                 310                 315                 320 


Lys Pro His Pro Pro Pro Pro Pro Ala Thr Arg Gly Thr Ser Thr Tyr 
                325                 330                 335     


Pro Thr Asp Phe Ser Gly Val Leu Gln Leu Trp Pro Pro Pro Ala Pro 
            340                 345                 350         


Pro Cys Leu Leu Arg Ala Ala Ser Lys Thr Lys Asp Asn Pro Gly Ser 
        355                 360                 365             


Ile Gly Lys Val Lys Val Met Leu Arg Ile Trp Pro Ala Gln Gly Ala 
    370                 375                 380                 


Gln Arg Ser Ala Glu Ala Met Ser Phe Leu Lys Val Asp Pro Arg Lys 
385                 390                 395                 400 


Lys Gln Val Ile Leu Tyr Asp Pro Ala Ala Gly Pro Pro Gly Ser Ala 
                405                 410                 415     


Gly Pro Arg Arg Ala Ala Thr Ala Ala Val Pro Lys Met Phe Ala Phe 
            420                 425                 430         


Asp Ala Val Phe Pro Gln Asp Ser Glu Gln Ala Glu Val Cys Ser Gly 
        435                 440                 445             


Thr Val Ala Asp Val Leu Gln Ser Val Val Ser Gly Ala Asp Gly Cys 
    450                 455                 460                 


Ile Phe Ser Phe Gly His Met Ser Leu Gly Lys Ser Tyr Thr Met Ile 
465                 470                 475                 480 


Gly Lys Asp Ser Ser Pro Gln Ser Leu Gly Ile Val Pro Cys Ala Ile 
                485                 490                 495     


Ser Trp Leu Phe Arg Leu Ile Glu Glu Arg Arg Glu Arg Thr Gly Thr 
            500                 505                 510         


Arg Phe Ser Val Arg Val Ser Ala Val Glu Val Cys Gly Arg Asp Gln 
        515                 520                 525             


Ser Leu Arg Asp Leu Leu Ala Glu Val Ala Pro Gly Ser Leu Gln Asp 
    530                 535                 540                 


Thr Gln Ser Pro Gly Val Tyr Leu Arg Glu Asp Pro Val Cys Gly Ala 
545                 550                 555                 560 


Gln Leu Gln Asn Gln Ser Glu Leu Arg Ala Pro Thr Ala Glu Lys Ala 
                565                 570                 575     


Ala Phe Tyr Leu Asp Ala Ala Leu Ala Ala Arg Ser Thr Ser Arg Ala 
            580                 585                 590         


Gly Cys Gly Glu Asp Ala Arg Arg Ser Ser His Met Leu Phe Thr Leu 
        595                 600                 605             


His Val Tyr Gln Tyr Arg Met Glu Lys Cys Gly Arg Gly Gly Met Ser 
    610                 615                 620                 


Gly Gly Arg Ser Arg Leu His Leu Ile Asp Leu Gly Ser Cys Glu Ala 
625                 630                 635                 640 


Ala Ala Gly Arg Ala Gly Glu Ala Ala Gly Gly Pro Leu Cys Leu Ser 
                645                 650                 655     


Leu Ser Ala Leu Gly Ser Val Ile Leu Ala Leu Val Asn Gly Ala Lys 
            660                 665                 670         


His Val Pro Tyr Arg Asp His Arg Leu Thr Met Leu Leu Arg Glu Ser 
        675                 680                 685             


Leu Ala Thr Ala Gly Cys Arg Thr Thr Met Ile Ala His Val Ser Asp 
    690                 695                 700                 


Ala Pro Ala Gln His Ala Glu Thr Leu Ser Thr Val Gln Leu Ala Ala 
705                 710                 715                 720 


Arg Ile His Arg Leu Arg Arg Lys Lys Ala Lys Tyr Ala Ser Ser Ser 
                725                 730                 735     


Ser Gly Gly Glu Ser Ser Cys Glu Glu Gly Arg Ala Arg Arg Pro Pro 
            740                 745                 750         


His Leu Arg Pro Phe His Pro Arg Thr Val Ala Leu Asp Pro Asp Arg 
        755                 760                 765             


Thr Pro Pro Cys Leu Pro Gly Asp Pro Asp Tyr Ser Ser Ser Ser Glu 
    770                 775                 780                 


Gln Ser Cys Asp Thr Val Ile Tyr Val Gly Pro Gly Gly Ala Ala Leu 
785                 790                 795                 800 


Ser Asp Arg Glu Leu Thr Asp Asn Glu Gly Pro Pro Asp Phe Val Pro 
                805                 810                 815     


Ile Ile Pro Ala Leu Ser Arg His Arg Pro Ser Lys Gly Pro Arg Asp 
            820                 825                 830         


Ala Asp His Phe Arg Cys Ser Thr Phe Ala Glu Leu Gln Glu Arg Leu 
        835                 840                 845             


Glu Cys Met Asp Gly Asn Glu Gly Pro Ser Gly Gly Pro Gly Gly Thr 
    850                 855                 860                 


Asp Gly Ala Gln Ala Ser Pro Ala Arg Gly Gly Arg Lys Pro Ser Pro 
865                 870                 875                 880 


Pro Glu Ala Ala Ser Pro Arg Lys Ala Val Gly Thr Pro Met Ala Ala 
                885                 890                 895     


Ser Thr Pro Arg Gly Ser Ser Gly Pro Asp Thr His Gln Gly Thr Pro 
            900                 905                 910         


Glu Pro Cys Lys Ala Ile Val Trp Gly Asp Gln Arg Glu Asp Ser Ser 
        915                 920                 925             


Ala Trp Pro Glu Leu Leu Val Pro Glu Lys Ala Ala Val Ser Gly Gly 
    930                 935                 940                 


Arg Arg Pro Leu Pro Ser Pro Ala Pro Pro Pro Pro Gln Leu Leu Glu 
945                 950                 955                 960 


Ala Cys Arg Ala Pro Glu Glu Pro Gly Gly Gly Gly Thr Asp Gly Val 
                965                 970                 975     


Ala Arg Thr Pro Pro Val Gly Met Ser Gly Gln Val Ala Gly Ser Pro 
            980                 985                 990         


Met Leu Pro Gly Ala Thr Cys Pro  Arg Leu Ala Ala Gly  Ser Arg Cys 
        995                 1000                 1005             


Pro Glu  Arg Gly Leu Leu Thr  Thr Thr Val Thr Leu  Gln Arg Pro 
    1010                 1015                 1020             


Val Glu  Leu Asn Gly Glu Asp  Glu Leu Val Phe Thr  Val Val Glu 
    1025                 1030                 1035             


Glu Leu  Ser Leu Gly Ala Leu  Ala Gly Ala Gly Arg  Pro Thr Ser 
    1040                 1045                 1050             


Leu Ala  Ser Phe Asp Ser Asp  Cys Ser Leu Arg Ala  Leu Ala Ser 
    1055                 1060                 1065             


Gly Ser  Arg Pro Val Ser Ile  Ile Ser Ser Ile Asn  Asp Glu Phe 
    1070                 1075                 1080             


Asp Ala  Tyr Thr Ser Gln Ala  Pro Glu Gly Gly Pro  Leu Glu Gly 
    1085                 1090                 1095             


Ala Ala  Trp Ala Gly Ser Ser  His Gly Ser Ser Ile  Ser Ser Trp 
    1100                 1105                 1110             


Leu Ser  Glu Val Ser Val Cys  Thr Ala Asp Ser Arg  Asp Pro Thr 
    1115                 1120                 1125             


Pro Gln  Pro Arg Phe Ser Pro  Asp Ser Leu Ala Gly  Leu Asp Pro 
    1130                 1135                 1140             


Gly Gly  Pro Pro Ala Leu Asp  Gly Ser Leu Gly Asp  Gly Ser Ser 
    1145                 1150                 1155             


Gly Phe  Leu Gly Pro Asp Arg  Pro Asp Ser Pro Gly  Pro Thr Trp 
    1160                 1165                 1170             


Gly Pro  Cys Pro Gly Glu Val  Ala Ala Val Ala Pro  Ser Arg Pro 
    1175                 1180                 1185             


Gly Arg  Glu Pro Gln Ala Gly  Pro Ser Arg Trp Ala  Ser Ala Ala 
    1190                 1195                 1200             


Gln Thr  Ile His Ser Ser Leu  Pro Arg Lys Pro Arg  Thr Ala Ser 
    1205                 1210                 1215             


Ala Thr  Thr Arg Val Gly Cys  Ala Arg Leu Gly Gln  Ser Pro Pro 
    1220                 1225                 1230             


Gly Arg  Gly Gly Leu Phe Glu  Asp Pro Trp Leu Leu  Arg Val Gly 
    1235                 1240                 1245             


Glu Cys  Asp Thr Gln Ala Ala  Ser Ala Gly Arg Ala  Pro Ser Pro 
    1250                 1255                 1260             


Thr Leu  Gly Ser Pro Arg Leu  Pro Glu Ala Gln Val  Met Leu Ala 
    1265                 1270                 1275             


Cys Ala  Gln Arg Val Val Asp  Gly Cys Glu Val Ala  Ala Arg Ala 
    1280                 1285                 1290             


Ala Arg  Arg Pro Glu Ala Val  Ala Arg Ile Pro Pro  Leu Arg Arg 
    1295                 1300                 1305             


Gly Ala  Thr Thr Leu Gly Val  Thr Thr Pro Ala Val  Ser Trp Gly 
    1310                 1315                 1320             


Asp Ala  Pro Thr Glu Val Val  Ala Cys Ser Gly Ser  Leu Lys Ala 
    1325                 1330                 1335             


Ser Pro  Thr Ser Lys Lys Gly  Leu Ala Pro Lys Ala  Gly Phe Leu 
    1340                 1345                 1350             


Pro Arg  Pro Ser Gly Ala Ala  Pro Pro Ala Pro Pro  Thr Arg Lys 
    1355                 1360                 1365             


Ser Ser  Leu Glu Gln Arg Ser  Ser Pro Ala Ser Ala  Pro Pro His 
    1370                 1375                 1380             


Ala Val  Asn Pro Ala Arg Val  Gly Ala Ala Ala Val  Leu Arg Gly 
    1385                 1390                 1395             


Glu Glu  Glu Pro Arg Pro Ser  Ser Arg Ala Asp His  Ser Val Pro 
    1400                 1405                 1410             


Arg Ala  Thr Ser Ser Leu Lys  Ala Arg Ala Ser Lys  Val Glu Ala 
    1415                 1420                 1425             


Ala His  Arg Leu Ala Gly His  Ala Ser Leu Glu Arg  Tyr Glu Gly 
    1430                 1435                 1440             


Leu Ala  His Ser Ser Ser Lys  Gly Arg Glu Ala Pro  Gly Arg Pro 
    1445                 1450                 1455             


Pro Arg  Ala Val Pro Lys Leu  Gly Val Pro Pro Ser  Ser Pro Thr 
    1460                 1465                 1470             


His Gly  Pro Ala Pro Ala Cys  Arg Ser Gly Ala Ala  Lys Ala Val 
    1475                 1480                 1485             


Gly Ala  Pro Lys Pro Pro Val  Gly Gly Gly Lys Gly  Arg Gly Leu 
    1490                 1495                 1500             


Val Ala  Gly Gly Ser Arg Ala  Leu Gly Pro Ser Val  Lys Leu Ser 
    1505                 1510                 1515             


Thr Ala  Ser Val Thr Gly Arg  Ser Pro Gly Gly Pro  Val Ala Gly 
    1520                 1525                 1530             


Pro Arg  Ala Ala Pro Arg Ala  Gly Pro Ser Val Gly  Ala Lys Ala 
    1535                 1540                 1545             


Gly Arg  Gly Thr Val Met Gly  Thr Lys Gln Ala Leu  Arg Ala Ala 
    1550                 1555                 1560             


His Ser  Arg Val His Glu Leu  Ser Ala Ser Gly Ala  Pro Gly Arg 
    1565                 1570                 1575             


Gly Gly  Ser Ser Trp Gly Ser  Ala Asp Ser Asp Ser  Gly His Asp 
    1580                 1585                 1590             


Ser Gly  Val Asn Val Gly Glu  Glu Arg Pro Pro Thr  Gly Pro Ala 
    1595                 1600                 1605             


Leu Pro  Ser Pro Tyr Ser Lys  Val Thr Ala Pro Arg  Arg Pro Gln 
    1610                 1615                 1620             


Arg Tyr  Ser Ser Gly His Gly  Ser Asp Asn Ser Ser  Val Leu Ser 
    1625                 1630                 1635             


Gly Glu  Leu Pro Pro Ala Met  Gly Arg Thr Ala Leu  Phe His His 
    1640                 1645                 1650             


Ser Gly  Gly Ser Ser Gly Tyr  Glu Ser Leu Arg Arg  Asp Ser Glu 
    1655                 1660                 1665             


Ala Thr  Gly Ser Ala Ser Ser  Ala Pro Asp Ser Met  Ser Glu Ser 
    1670                 1675                 1680             


Gly Ala  Ala Ser Pro Gly Ala  Arg Thr Arg Ser Leu  Lys Ser Pro 
    1685                 1690                 1695             


Lys Lys  Arg Ala Thr Gly Leu  Gln Arg Arg Arg Leu  Ile Pro Ala 
    1700                 1705                 1710             


Pro Leu  Pro Asp Thr Thr Ala  Leu Gly Arg Lys Pro  Ser Leu Pro 
    1715                 1720                 1725             


Gly Gln  Trp Val Asp Leu Pro  Pro Pro Leu Ala Gly  Ser Leu Lys 
    1730                 1735                 1740             


Glu Pro  Phe Glu Ile Lys Val  Tyr Glu Ile Asp Asp  Val Glu Arg 
    1745                 1750                 1755             


Leu Gln  Arg Pro Arg Pro Thr  Pro Arg Glu Ala Pro  Thr Gln Gly 
    1760                 1765                 1770             


Leu Ala  Cys Val Ser Thr Arg  Leu Arg Leu Ala Glu  Arg Arg Gln 
    1775                 1780                 1785             


Gln Arg  Leu Arg Glu Val Gln  Ala Lys His Lys His  Leu Cys Glu 
    1790                 1795                 1800             


Glu Leu  Ala Glu Thr Gln Gly  Arg Leu Met Leu Glu  Pro Gly Arg 
    1805                 1810                 1815             


Trp Leu  Glu Gln Phe Glu Val  Asp Pro Glu Leu Glu  Pro Glu Ser 
    1820                 1825                 1830             


Ala Glu  Tyr Leu Ala Ala Leu  Glu Arg Ala Thr Ala  Ala Leu Glu 
    1835                 1840                 1845             


Gln Cys  Val Asn Leu Cys Lys  Ala His Val Met Met  Val Thr Cys 
    1850                 1855                 1860             


Phe Asp  Ile Ser Val Ala Ala  Ser Ala Ala Ile Pro  Gly Pro Gln 
    1865                 1870                 1875             


Glu Val  Asp Val 
    1880         


<210>  5886
<211>  2108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF26B__Homo_sapiens__NP_060482

<400>  5886

Met Asn Ser Val Ala Gly Asn Lys Glu Arg Leu Ala Val Ser Thr Arg 
1               5                   10                  15      


Gly Lys Lys Tyr Gly Val Asn Glu Val Cys Ser Pro Thr Lys Pro Ala 
            20                  25                  30          


Ala Pro Phe Ser Pro Glu Ser Trp Tyr Arg Lys Ala Tyr Glu Glu Ser 
        35                  40                  45              


Arg Ala Gly Ser Arg Pro Thr Pro Glu Gly Ala Gly Ser Ala Leu Gly 
    50                  55                  60                  


Ser Ser Gly Thr Pro Ser Pro Gly Ser Gly Thr Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Phe Thr Gly Ser Pro Gly Pro Ala Ser Pro Gly Ile Gly Thr Ser Ser 
                85                  90                  95      


Pro Gly Ser Leu Gly Gly Ser Pro Gly Phe Gly Thr Gly Ser Pro Gly 
            100                 105                 110         


Ser Gly Ser Gly Gly Gly Ser Ser Pro Gly Ser Asp Arg Gly Val Trp 
        115                 120                 125             


Cys Glu Asn Cys Asn Ala Arg Leu Val Glu Leu Lys Arg Gln Ala Leu 
    130                 135                 140                 


Arg Leu Leu Leu Pro Gly Pro Phe Pro Gly Lys Asp Pro Ala Phe Ser 
145                 150                 155                 160 


Ala Val Ile His Asp Lys Leu Gln Val Pro Asn Thr Ile Arg Lys Ala 
                165                 170                 175     


Trp Asn Asp Arg Asp Asn Arg Cys Asp Ile Cys Ala Thr His Leu Asn 
            180                 185                 190         


Gln Leu Lys Gln Glu Ala Ile Gln Met Val Leu Thr Leu Glu Gln Ala 
        195                 200                 205             


Ala Gly Ser Glu His Tyr Asp Ala Ser Pro Cys Ser Pro Pro Pro Leu 
    210                 215                 220                 


Ser Asn Ile Pro Thr Leu Val Gly Ser Arg His Val Gly Gly Leu Gln 
225                 230                 235                 240 


Gln Pro Arg Asp Trp Ala Phe Val Pro Ala Pro Cys Ala Thr Ser Asn 
                245                 250                 255     


Tyr Thr Gly Phe Ala Asn Lys His Gly Ser Lys Pro Ser Ser Leu Gly 
            260                 265                 270         


Val Ser Asn Gly Ala Glu Lys Lys Ser Gly Ser Pro Thr His Gln Ala 
        275                 280                 285             


Lys Val Ser Leu Gln Met Ala Thr Ser Pro Ser Asn Gly Asn Ile Leu 
    290                 295                 300                 


Asn Ser Val Ala Ile Gln Ala His Gln Tyr Leu Asp Gly Thr Trp Ser 
305                 310                 315                 320 


Leu Ser Arg Thr Asn Gly Val Thr Leu Tyr Pro Tyr Gln Ile Ser Gln 
                325                 330                 335     


Leu Met Thr Glu Ser Ser Arg Glu Gly Leu Thr Glu Ala Val Leu Asn 
            340                 345                 350         


Arg Tyr Asn Ala Asp Lys Pro Ser Ala Cys Ser Val Pro Ala Ser Gln 
        355                 360                 365             


Gly Ser Cys Val Ala Ser Glu Thr Ser Thr Gly Thr Ser Val Ala Ala 
    370                 375                 380                 


Ser Phe Phe Ala Arg Ala Ala Gln Lys Leu Asn Leu Ser Ser Lys Lys 
385                 390                 395                 400 


Lys Lys His Arg Pro Ser Thr Ser Ser Ala Ala Glu Pro Pro Leu Phe 
                405                 410                 415     


Ala Thr Ser Phe Ser Gly Ile Leu Gln Thr Ser Pro Pro Pro Ala Pro 
            420                 425                 430         


Pro Cys Leu Leu Arg Ala Val Asn Lys Val Lys Asp Thr Pro Gly Leu 
        435                 440                 445             


Gly Lys Val Lys Val Met Leu Arg Ile Cys Ser Thr Leu Ala Arg Asp 
    450                 455                 460                 


Thr Ser Glu Ser Ser Ser Phe Leu Lys Val Asp Pro Arg Lys Lys Gln 
465                 470                 475                 480 


Ile Thr Leu Tyr Asp Pro Leu Thr Cys Gly Gly Gln Asn Ala Phe Gln 
                485                 490                 495     


Lys Arg Gly Asn Gln Val Pro Pro Lys Met Phe Ala Phe Asp Ala Val 
            500                 505                 510         


Phe Pro Gln Asp Ala Ser Gln Ala Glu Val Cys Ala Gly Thr Val Ala 
        515                 520                 525             


Glu Val Ile Gln Ser Val Val Asn Gly Ala Asp Gly Cys Val Phe Cys 
    530                 535                 540                 


Phe Gly His Ala Lys Leu Gly Lys Ser Tyr Thr Met Ile Gly Lys Asp 
545                 550                 555                 560 


Asp Ser Met Gln Asn Leu Gly Ile Ile Pro Cys Ala Ile Ser Trp Leu 
                565                 570                 575     


Phe Lys Leu Ile Asn Glu Arg Lys Glu Lys Thr Gly Ala Arg Phe Ser 
            580                 585                 590         


Val Arg Val Ser Ala Val Glu Val Trp Gly Lys Glu Glu Asn Leu Arg 
        595                 600                 605             


Asp Leu Leu Ser Glu Val Ala Thr Gly Ser Leu Gln Asp Gly Gln Ser 
    610                 615                 620                 


Pro Gly Val Tyr Leu Cys Glu Asp Pro Ile Cys Gly Thr Gln Leu Gln 
625                 630                 635                 640 


Asn Gln Ser Glu Leu Arg Ala Pro Thr Ala Glu Lys Ala Ala Phe Phe 
                645                 650                 655     


Leu Asp Ala Ala Ile Ala Ser Arg Arg Ser His Gln Gln Asp Cys Asp 
            660                 665                 670         


Glu Asp Asp His Arg Asn Ser His Val Phe Phe Thr Leu His Ile Tyr 
        675                 680                 685             


Gln Tyr Arg Met Glu Lys Ser Gly Lys Gly Gly Met Ser Gly Gly Arg 
    690                 695                 700                 


Ser Arg Leu His Leu Ile Asp Leu Gly Ser Cys Val Lys Ala Leu Ser 
705                 710                 715                 720 


Lys Asn Arg Glu Gly Gly Ser Gly Leu Cys Leu Ser Leu Ser Ala Leu 
                725                 730                 735     


Gly Asn Val Ile Leu Ala Leu Val Asn Gly Ser Lys His Ile Pro Tyr 
            740                 745                 750         


Lys Glu Ser Lys Leu Ala Met Leu Leu Arg Glu Ser Leu Gly Asn Met 
        755                 760                 765             


Asn Cys Arg Thr Thr Met Ile Ala His Ile Ser Ala Ala Val Gly Ser 
    770                 775                 780                 


Tyr Ala Glu Thr Leu Ser Thr Ile Gln Ile Ala Ser Arg Val Leu Arg 
785                 790                 795                 800 


Met Lys Lys Lys Lys Thr Lys Tyr Thr Ser Ser Ser Ser Gly Gly Glu 
                805                 810                 815     


Ser Ser Cys Glu Glu Gly Arg Met Arg Arg Pro Thr Gln Leu Arg Pro 
            820                 825                 830         


Phe His Thr Arg Ala Thr Val Asp Pro Asp Phe Pro Ile Ala His Leu 
        835                 840                 845             


Ser Ser Asp Pro Asp Tyr Ser Ser Ser Ser Glu Gln Ser Cys Asp Thr 
    850                 855                 860                 


Val Ile Tyr Ile Gly Pro Asn Gly Thr Ala Leu Ser Asp Lys Glu Leu 
865                 870                 875                 880 


Thr Asp Asn Glu Gly Pro Pro Asp Phe Val Pro Ile Val Pro Ala Leu 
                885                 890                 895     


Gln Lys Thr Arg Gly Asp Ser Arg Pro Ala Glu Ala Gly Glu Ala Ala 
            900                 905                 910         


Ala Gly Lys Ser Glu Arg Asp Cys Leu Lys Cys Asn Thr Phe Ala Glu 
        915                 920                 925             


Leu Gln Glu Arg Leu Asp Cys Ile Asp Gly Ser Glu Glu Pro Ser Ser 
    930                 935                 940                 


Phe Pro Phe Glu Glu Leu Pro Ala Gln Phe Gly Pro Glu Gln Ala Ser 
945                 950                 955                 960 


Arg Gly Pro Arg Leu Ser Gln Ala Ala Gly Ala Ser Pro Leu Ser Glu 
                965                 970                 975     


Ser Asp Lys Glu Asp Asn Gly Ser Glu Gly Gln Leu Thr Asn Arg Glu 
            980                 985                 990         


Gly Pro Glu Leu Pro Ala Ser Lys  Met Gln Arg Ser His  Ser Pro Val 
        995                 1000                 1005             


Pro Ala  Ala Ala Pro Ala His  Ser Pro Ser Pro Ala  Ser Pro Arg 
    1010                 1015                 1020             


Ser Val  Pro Gly Ser Ser Ser  Gln His Ser Ala Ser  Pro Leu Val 
    1025                 1030                 1035             


Gln Ser  Pro Ser Leu Gln Ser  Ser Arg Glu Ser Leu  Asn Ser Cys 
    1040                 1045                 1050             


Gly Phe  Val Glu Gly Lys Pro  Arg Pro Met Gly Ser  Pro Arg Leu 
    1055                 1060                 1065             


Gly Ile  Ala Ser Leu Ser Lys  Thr Ser Glu Tyr Lys  Pro Pro Ser 
    1070                 1075                 1080             


Ser Pro  Ser Gln Arg Cys Lys  Val Tyr Thr Gln Lys  Gly Val Leu 
    1085                 1090                 1095             


Pro Ser  Pro Ala Pro Leu Pro  Pro Ser Ser Lys Asp  Ser Gly Val 
    1100                 1105                 1110             


Ala Ser  Arg Glu Ser Leu Leu  Gln Pro Glu Val Arg  Thr Pro Pro 
    1115                 1120                 1125             


Val Gly  Met Ser Pro Gln Val  Leu Lys Lys Ser Met  Ser Ala Gly 
    1130                 1135                 1140             


Ser Glu  Gly Phe Pro Glu Thr  Pro Val Asp Asp Glu  Gln Gln Ala 
    1145                 1150                 1155             


Ala Thr  Pro Ser Glu Ser Lys  Lys Glu Ile Leu Ser  Thr Thr Met 
    1160                 1165                 1170             


Val Thr  Val Gln Gln Pro Leu  Glu Leu Asn Gly Glu  Asp Glu Leu 
    1175                 1180                 1185             


Val Phe  Thr Leu Val Glu Glu  Leu Thr Ile Ser Gly  Val Leu Asp 
    1190                 1195                 1200             


Ser Gly  Arg Pro Thr Ser Ile  Ile Ser Phe Asn Ser  Asp Cys Ser 
    1205                 1210                 1215             


Ala Arg  Ala Leu Ala Ser Gly  Ser Arg Pro Val Ser  Ile Ile Ser 
    1220                 1225                 1230             


Ser Ile  Ser Glu Asp Leu Glu  Cys Tyr Ser Ser Thr  Ala Pro Val 
    1235                 1240                 1245             


Ser Glu  Val Ser Ile Thr Gln  Phe Leu Pro Leu Pro  Lys Met Ser 
    1250                 1255                 1260             


Leu Asp  Glu Lys Ala Gln Asp  Ala Gly Ser Arg Arg  Ser Ser Ile 
    1265                 1270                 1275             


Ser Ser  Trp Leu Ser Glu Met  Ser Ala Gly Ser Glu  Gly Glu Gln 
    1280                 1285                 1290             


Ser Cys  His Ser Phe Ile Ala  Gln Thr Cys Phe Gly  His Gly Glu 
    1295                 1300                 1305             


Ala Met  Ala Glu Pro Val Ala  Ser Glu Phe Val Ser  Ser Leu Gln 
    1310                 1315                 1320             


Asn Thr  Ala Val Val Cys Arg  Glu Lys Pro Lys Ala  Ser Pro Asp 
    1325                 1330                 1335             


Asn Leu  Leu Ile Leu Ser Glu  Met Gly Asp Asp Ser  Phe Asn Lys 
    1340                 1345                 1350             


Ala Ala  Pro Ile Lys Gly Cys  Lys Ile Ser Thr Val  Ser Lys Ala 
    1355                 1360                 1365             


Met Val  Thr Ile Ser Asn Thr  Ala Asn Leu Ser Ser  Cys Glu Gly 
    1370                 1375                 1380             


Tyr Ile  Pro Met Lys Thr Asn  Ile Thr Val Tyr Pro  Cys Ile Ala 
    1385                 1390                 1395             


Met Ser  Pro Arg Asn Ile Gln  Glu Pro Glu Ala Pro  Thr Ala Thr 
    1400                 1405                 1410             


Pro Lys  Ala Gly Pro Thr Leu  Ala Gln Ser Arg Glu  Ser Lys Glu 
    1415                 1420                 1425             


Asn Ser  Ala Lys Lys Glu Met  Lys Phe Glu Asp Pro  Trp Leu Lys 
    1430                 1435                 1440             


Arg Glu  Glu Glu Val Lys Lys  Glu Thr Ala His Pro  Asn Glu Glu 
    1445                 1450                 1455             


Gly Met  Met Arg Cys Glu Thr  Ala Thr Gly Pro Ser  Asn Ala Glu 
    1460                 1465                 1470             


Thr Arg  Ala Glu Gln Glu Gln  Asp Gly Lys Pro Ser  Pro Gly Asp 
    1475                 1480                 1485             


Arg Leu  Ser Ser Ser Ser Gly  Glu Val Ser Ala Ser  Pro Val Thr 
    1490                 1495                 1500             


Asp Asn  Phe Arg Arg Val Val  Asp Gly Cys Glu Met  Ala Leu Pro 
    1505                 1510                 1515             


Gly Leu  Ala Thr Gln Ser Pro  Val His Pro Asn Lys  Ser Val Lys 
    1520                 1525                 1530             


Ser Ser  Ser Leu Pro Arg Ala  Phe Gln Lys Ala Ser  Arg Gln Glu 
    1535                 1540                 1545             


Glu Pro  Asp Ser Leu Ser Tyr  Tyr Cys Ala Ala Glu  Thr Asn Gly 
    1550                 1555                 1560             


Val Gly  Ala Ala Ser Gly Thr  Pro Pro Ser Lys Ala  Thr Leu Glu 
    1565                 1570                 1575             


Gly Lys  Val Ala Ser Pro Lys  His Cys Val Leu Ala  Arg Pro Lys 
    1580                 1585                 1590             


Gly Thr  Pro Pro Leu Pro Pro  Val Arg Lys Ser Ser  Leu Asp Gln 
    1595                 1600                 1605             


Lys Asn  Arg Ala Ser Pro Gln  His Ser Ala Ser Gly  Ser Gly Thr 
    1610                 1615                 1620             


Ser Ser  Pro Leu Asn Gln Pro  Ala Ala Phe Pro Ala  Gly Leu Pro 
    1625                 1630                 1635             


Asp Glu  Pro Ser Gly Lys Thr  Lys Asp Ala Ser Ser  Ser Ser Lys 
    1640                 1645                 1650             


Leu Phe  Ser Ala Lys Leu Glu  Gln Leu Ala Ser Arg  Ser Asn Ser 
    1655                 1660                 1665             


Leu Gly  Arg Ala Thr Val Ser  His Tyr Glu Cys Leu  Ser Leu Glu 
    1670                 1675                 1680             


Arg Ala  Glu Ser Leu Ser Ser  Val Ser Ser Arg Leu  His Ala Gly 
    1685                 1690                 1695             


Lys Asp  Gly Thr Met Pro Arg  Ala Gly Arg Ser Leu  Gly Arg Ser 
    1700                 1705                 1710             


Ala Gly  Thr Ser Pro Pro Ser  Ser Gly Ala Ser Pro  Lys Ala Gly 
    1715                 1720                 1725             


Gln Ser  Lys Ile Ser Ala Val  Ser Arg Leu Leu Leu  Ala Ser Pro 
    1730                 1735                 1740             


Arg Ala  Arg Gly Pro Ser Ala  Ser Thr Thr Lys Thr  Leu Ser Phe 
    1745                 1750                 1755             


Ser Thr  Lys Ser Leu Pro Gln  Ala Val Gly Gln Gly  Ser Ser Ser 
    1760                 1765                 1770             


Pro Pro  Gly Gly Lys His Thr  Pro Trp Ser Thr Gln  Ser Leu Ser 
    1775                 1780                 1785             


Arg Asn  Arg Ser Ser Gly Leu  Ala Ser Lys Leu Pro  Leu Arg Ala 
    1790                 1795                 1800             


Val Ser  Gly Arg Ile Ser Glu  Leu Leu Gln Gly Gly  Ala Gly Ala 
    1805                 1810                 1815             


Arg Gly  Leu Gln Leu Arg Ala  Gly Pro Glu Ala Glu  Ala Arg Gly 
    1820                 1825                 1830             


Gly Ala  Leu Ala Glu Asp Glu  Pro Ala Ala Ala His  Leu Leu Pro 
    1835                 1840                 1845             


Ser Pro  Tyr Ser Lys Ile Thr  Pro Pro Arg Arg Pro  His Arg Cys 
    1850                 1855                 1860             


Ser Ser  Gly His Gly Ser Asp  Asn Ser Ser Val Leu  Ser Gly Glu 
    1865                 1870                 1875             


Leu Pro  Pro Ala Met Gly Lys  Thr Ala Leu Phe Tyr  His Ser Gly 
    1880                 1885                 1890             


Gly Ser  Ser Gly Tyr Glu Ser  Val Met Arg Asp Ser  Glu Ala Thr 
    1895                 1900                 1905             


Gly Ser  Ala Ser Ser Ala Gln  Asp Ser Thr Ser Glu  Asn Ser Ser 
    1910                 1915                 1920             


Ser Val  Gly Gly Arg Cys Arg  Ser Leu Lys Thr Pro  Lys Lys Arg 
    1925                 1930                 1935             


Ser Asn  Pro Gly Ser Gln Arg  Arg Arg Leu Ile Pro  Ala Leu Ser 
    1940                 1945                 1950             


Leu Asp  Thr Ser Ser Pro Val  Arg Lys Pro Pro Asn  Ser Thr Gly 
    1955                 1960                 1965             


Val Arg  Trp Val Asp Gly Pro  Leu Arg Ser Ser Pro  Arg Gly Leu 
    1970                 1975                 1980             


Gly Glu  Pro Phe Glu Ile Lys  Val Tyr Glu Ile Asp  Asp Val Glu 
    1985                 1990                 1995             


Arg Leu  Gln Arg Arg Arg Gly  Gly Ala Ser Lys Glu  Ala Met Cys 
    2000                 2005                 2010             


Phe Asn  Ala Lys Leu Lys Ile  Leu Glu His Arg Gln  Gln Arg Ile 
    2015                 2020                 2025             


Ala Glu  Val Arg Ala Lys Tyr  Glu Trp Leu Met Lys  Glu Leu Glu 
    2030                 2035                 2040             


Ala Thr  Lys Gln Tyr Leu Met  Leu Asp Pro Asn Lys  Trp Leu Ser 
    2045                 2050                 2055             


Glu Phe  Asp Leu Glu Gln Val  Trp Glu Leu Asp Ser  Leu Glu Tyr 
    2060                 2065                 2070             


Leu Glu  Ala Leu Glu Cys Val  Thr Glu Arg Leu Glu  Ser Arg Val 
    2075                 2080                 2085             


Asn Phe  Cys Lys Ala His Leu  Met Met Ile Thr Cys  Phe Asp Ile 
    2090                 2095                 2100             


Thr Ser  Arg Arg Arg 
    2105             


<210>  5887
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF2A__Homo_sapiens__NP_001091981

<400>  5887

Met Ala Thr Ala Asn Phe Gly Lys Ile Gln Ile Gly Ile Tyr Val Glu 
1               5                   10                  15      


Ile Lys Arg Ser Asp Gly Arg Ile His Gln Ala Met Val Thr Ser Leu 
            20                  25                  30          


Asn Glu Asp Asn Glu Ser Val Thr Val Glu Trp Ile Glu Asn Gly Asp 
        35                  40                  45              


Thr Lys Gly Lys Glu Ile Asp Leu Glu Ser Ile Phe Ser Leu Asn Pro 
    50                  55                  60                  


Asp Leu Val Pro Asp Glu Glu Ile Glu Pro Ser Pro Glu Thr Pro Pro 
65                  70                  75                  80  


Pro Pro Ala Ser Ser Ala Lys Val Asn Lys Ile Val Lys Asn Arg Arg 
                85                  90                  95      


Thr Val Ala Ser Ile Lys Asn Asp Pro Pro Ser Arg Asp Asn Arg Val 
            100                 105                 110         


Val Gly Ser Ala Arg Ala Arg Pro Ser Gln Phe Pro Glu Gln Ser Ser 
        115                 120                 125             


Ser Ala Gln Gln Asn Gly Ser Val Ser Asp Ile Ser Pro Val Gln Ala 
    130                 135                 140                 


Ala Lys Lys Glu Phe Gly Pro Pro Ser Arg Arg Lys Ser Asn Cys Val 
145                 150                 155                 160 


Lys Glu Val Glu Lys Leu Gln Glu Lys Arg Glu Lys Arg Arg Leu Gln 
                165                 170                 175     


Gln Gln Glu Leu Arg Glu Lys Arg Ala Gln Asp Val Asp Ala Thr Asn 
            180                 185                 190         


Pro Asn Tyr Glu Ile Met Cys Met Ile Arg Asp Phe Arg Gly Ser Leu 
        195                 200                 205             


Asp Tyr Arg Pro Leu Thr Thr Ala Asp Pro Ile Asp Glu His Arg Ile 
    210                 215                 220                 


Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Lys Glu Thr Gln Met 
225                 230                 235                 240 


Lys Asp Leu Asp Val Ile Thr Ile Pro Ser Lys Asp Val Val Met Val 
                245                 250                 255     


His Glu Pro Lys Gln Lys Val Asp Leu Thr Arg Tyr Leu Glu Asn Gln 
            260                 265                 270         


Thr Phe Arg Phe Asp Tyr Ala Phe Asp Asp Ser Ala Pro Asn Glu Met 
        275                 280                 285             


Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Glu Thr Ile Phe Glu Arg 
    290                 295                 300                 


Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr 
305                 310                 315                 320 


His Thr Met Gly Gly Asp Phe Ser Gly Lys Asn Gln Asp Cys Ser Lys 
                325                 330                 335     


Gly Ile Tyr Ala Leu Ala Ala Arg Asp Val Phe Leu Met Leu Lys Lys 
            340                 345                 350         


Pro Asn Tyr Lys Lys Leu Glu Leu Gln Val Tyr Ala Thr Phe Phe Glu 
        355                 360                 365             


Ile Tyr Ser Gly Lys Val Phe Asp Leu Leu Asn Arg Lys Thr Lys Leu 
    370                 375                 380                 


Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val Gly Leu Gln 
385                 390                 395                 400 


Glu Arg Glu Val Lys Cys Val Glu Asp Val Leu Lys Leu Ile Asp Ile 
                405                 410                 415     


Gly Asn Ser Cys Arg Thr Ser Gly Gln Thr Ser Ala Asn Ala His Ser 
            420                 425                 430         


Ser Arg Ser His Ala Val Phe Gln Ile Ile Leu Arg Arg Lys Gly Lys 
        435                 440                 445             


Leu His Gly Lys Phe Ser Leu Ile Asp Leu Ala Gly Asn Glu Arg Gly 
    450                 455                 460                 


Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Leu Glu Gly Ala Glu 
465                 470                 475                 480 


Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg Ala Leu Gly 
                485                 490                 495     


Arg Asn Lys Pro His Thr Pro Phe Arg Ala Ser Lys Leu Thr Gln Val 
            500                 505                 510         


Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys Met Ile Ala 
        515                 520                 525             


Thr Ile Ser Pro Gly Met Ala Ser Cys Glu Asn Thr Leu Asn Thr Leu 
    530                 535                 540                 


Arg Tyr Ala Asn Arg Val Lys Glu Phe Gly Ile Ser Pro Ser Asp Ile 
545                 550                 555                 560 


Pro Phe Ser Gln Gly Ser Gly Ser Arg Pro Asp Leu Ser Pro Ser Tyr 
                565                 570                 575     


Glu Tyr Asp Asp Phe Ser Pro Ser Val Thr Arg Val Lys Glu Leu Thr 
            580                 585                 590         


Val Asp Pro Thr Ala Ala Gly Asp Val Arg Pro Ile Met His His Pro 
        595                 600                 605             


Pro Asn Gln Ile Asp Asp Leu Glu Thr Gln Trp Gly Val Gly Ser Ser 
    610                 615                 620                 


Pro Gln Arg Asp Asp Leu Lys Leu Leu Cys Glu Gln Asn Glu Glu Glu 
625                 630                 635                 640 


Val Ser Pro Gln Leu Phe Thr Phe His Glu Ala Val Ser Gln Met Val 
                645                 650                 655     


Glu Met Glu Glu Gln Val Val Glu Asp His Arg Ala Val Phe Gln Glu 
            660                 665                 670         


Ser Ile Arg Trp Leu Glu Asp Glu Lys Ala Leu Leu Glu Met Thr Glu 
        675                 680                 685             


Glu Val Asp Tyr Asp Val Asp Ser Tyr Ala Thr Gln Leu Glu Ala Ile 
    690                 695                 700                 


Leu Glu Gln Lys Ile Asp Ile Leu Thr Glu Leu Arg Asp Lys Val Lys 
705                 710                 715                 720 


Ser Phe Arg Ala Ala Leu Gln Glu Glu Glu Gln Ala Ser Lys Gln Ile 
                725                 730                 735     


Asn Pro Lys Arg Pro Arg Ala Leu 
            740                 


<210>  5888
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF2B__Homo_sapiens__NP_115948

<400>  5888

Met Ala Ser Gln Phe Cys Leu Pro Glu Ser Pro Cys Leu Ser Pro Leu 
1               5                   10                  15      


Lys Pro Leu Lys Pro His Phe Gly Asp Ile Gln Glu Gly Ile Tyr Val 
            20                  25                  30          


Ala Ile Gln Arg Ser Asp Lys Arg Ile His Leu Ala Val Val Thr Glu 
        35                  40                  45              


Ile Asn Arg Glu Asn Tyr Trp Val Thr Val Glu Trp Val Glu Lys Ala 
    50                  55                  60                  


Val Lys Lys Gly Lys Lys Ile Asp Leu Glu Thr Ile Leu Leu Leu Asn 
65                  70                  75                  80  


Pro Ala Leu Asp Ser Ala Glu His Pro Met Pro Pro Pro Pro Leu Ser 
                85                  90                  95      


Pro Leu Ala Leu Ala Pro Ser Ser Ala Ile Arg Asp Gln Arg Thr Ala 
            100                 105                 110         


Thr Lys Trp Val Ala Met Ile Pro Gln Lys Asn Gln Thr Ala Ser Gly 
        115                 120                 125             


Asp Ser Leu Asp Val Arg Val Pro Ser Lys Pro Cys Leu Met Lys Gln 
    130                 135                 140                 


Lys Lys Ser Pro Cys Leu Trp Glu Ile Gln Lys Leu Gln Glu Gln Arg 
145                 150                 155                 160 


Glu Lys Arg Arg Arg Leu Gln Gln Glu Ile Arg Ala Arg Arg Ala Leu 
                165                 170                 175     


Asp Val Asn Thr Arg Asn Pro Asn Tyr Glu Ile Met His Met Ile Glu 
            180                 185                 190         


Glu Tyr Arg Arg His Leu Asp Ser Ser Lys Ile Ser Val Leu Glu Pro 
        195                 200                 205             


Pro Gln Glu His Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn 
    210                 215                 220                 


Gln Arg Glu Thr Thr Leu Lys Asp Leu Asp Ile Ile Thr Val Pro Ser 
225                 230                 235                 240 


Asp Asn Val Val Met Val His Glu Ser Lys Gln Lys Val Asp Leu Thr 
                245                 250                 255     


Arg Tyr Leu Gln Asn Gln Thr Phe Cys Phe Asp His Ala Phe Asp Asp 
            260                 265                 270         


Lys Ala Ser Asn Glu Leu Val Tyr Gln Phe Thr Ala Gln Pro Leu Val 
        275                 280                 285             


Glu Ser Ile Phe Arg Lys Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln 
    290                 295                 300                 


Thr Gly Ser Gly Lys Thr Tyr Thr Met Gly Gly Asp Phe Ser Gly Thr 
305                 310                 315                 320 


Ala Gln Asp Cys Ser Lys Gly Ile Tyr Ala Leu Val Ala Gln Asp Val 
                325                 330                 335     


Phe Leu Leu Leu Arg Asn Ser Thr Tyr Glu Lys Leu Asp Leu Lys Val 
            340                 345                 350         


Tyr Gly Thr Phe Phe Glu Ile Tyr Gly Gly Lys Val Tyr Asp Leu Leu 
        355                 360                 365             


Asn Trp Lys Lys Lys Leu Gln Val Leu Glu Asp Gly Asn Gln Gln Ile 
    370                 375                 380                 


Gln Val Val Gly Leu Gln Glu Lys Glu Val Cys Cys Val Glu Glu Val 
385                 390                 395                 400 


Leu Asn Leu Val Glu Ile Gly Asn Ser Cys Arg Thr Ser Arg Gln Thr 
                405                 410                 415     


Pro Val Asn Ala His Ser Ser Arg Ser His Ala Val Phe Gln Ile Ile 
            420                 425                 430         


Leu Lys Ser Gly Arg Ile Met His Gly Lys Phe Ser Leu Val Asp Leu 
        435                 440                 445             


Ala Gly Asn Glu Arg Gly Ala Asp Thr Thr Lys Ala Ser Arg Lys Arg 
    450                 455                 460                 


Gln Leu Glu Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu 
465                 470                 475                 480 


Cys Ile Leu Ala Leu Gly Gln Asn Lys Pro His Thr Pro Phe Arg Ala 
                485                 490                 495     


Ser Lys Leu Thr Leu Val Leu Arg Asp Ser Phe Ile Gly Gln Asn Ser 
            500                 505                 510         


Ser Thr Cys Met Ile Ala Thr Ile Ser Pro Gly Met Thr Ser Cys Glu 
        515                 520                 525             


Asn Thr Leu Asn Thr Leu Arg Tyr Ala Asn Arg Val Lys Lys Leu Asn 
    530                 535                 540                 


Val Asp Val Arg Pro Tyr His Arg Gly His Tyr Pro Ile Gly His Glu 
545                 550                 555                 560 


Ala Pro Arg Met Leu Lys Ser His Ile Gly Asn Ser Glu Met Ser Leu 
                565                 570                 575     


Gln Arg Asp Glu Phe Ile Lys Ile Pro Tyr Val Gln Ser Glu Glu Gln 
            580                 585                 590         


Lys Glu Ile Glu Glu Val Glu Thr Leu Pro Thr Leu Leu Gly Lys Asp 
        595                 600                 605             


Thr Thr Ile Ser Gly Lys Gly Ser Ser Gln Trp Leu Glu Asn Ile Gln 
    610                 615                 620                 


Glu Arg Ala Gly Gly Val His His Asp Ile Asp Phe Cys Ile Ala Arg 
625                 630                 635                 640 


Ser Leu Ser Ile Leu Glu Gln Lys Ile Asp Ala Leu Thr Glu Ile Gln 
                645                 650                 655     


Lys Lys Leu Lys Leu Leu Leu Ala Asp Leu His Val Lys Ser Lys Val 
            660                 665                 670         


Glu 
    


<210>  5889
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF2C__Homo_sapiens__NP_001284584

<400>  5889

Met Ala Met Asp Ser Ser Leu Gln Ala Arg Leu Phe Pro Gly Leu Ala 
1               5                   10                  15      


Ile Lys Ile Gln Arg Ser Asn Gly Leu Ile His Ser Ala Asn Val Arg 
            20                  25                  30          


Thr Val Asn Leu Glu Lys Ser Cys Val Ser Val Glu Trp Ala Glu Gly 
        35                  40                  45              


Gly Ala Thr Lys Gly Lys Glu Ile Asp Phe Asp Asp Val Ala Ala Ile 
    50                  55                  60                  


Asn Pro Glu Leu Leu Gln Leu Leu Pro Leu His Pro Lys Asp Asn Leu 
65                  70                  75                  80  


Pro Leu Gln Glu Asn Val Thr Ile Gln Lys Gln Lys Arg Arg Ser Val 
                85                  90                  95      


Asn Ser Lys Ile Pro Ala Pro Lys Glu Ser Leu Arg Ser Arg Ser Thr 
            100                 105                 110         


Arg Met Ser Thr Val Ser Glu Leu Arg Ile Thr Ala Gln Glu Asn Asp 
        115                 120                 125             


Met Glu Val Glu Leu Pro Ala Ala Ala Asn Ser Arg Lys Gln Phe Ser 
    130                 135                 140                 


Val Pro Leu Arg Arg Lys Ser Cys Leu Val Lys Glu Val Glu Lys Met 
145                 150                 155                 160 


Lys Asn Lys Arg Glu Glu Lys Lys Ala Gln Asn Ser Glu Met Arg Met 
                165                 170                 175     


Lys Arg Ala Gln Glu Tyr Asp Ser Ser Phe Pro Asn Trp Glu Phe Ala 
            180                 185                 190         


Arg Met Ile Lys Glu Phe Arg Ala Thr Leu Glu Cys His Pro Leu Thr 
        195                 200                 205             


Met Thr Asp Pro Ile Glu Glu His Arg Ile Cys Val Cys Val Arg Lys 
    210                 215                 220                 


Arg Pro Leu Asn Lys Gln Glu Leu Ala Lys Lys Glu Ile Asp Val Ile 
225                 230                 235                 240 


Ser Ile Pro Ser Lys Cys Leu Leu Leu Val His Glu Pro Lys Leu Lys 
                245                 250                 255     


Val Asp Leu Thr Lys Tyr Leu Glu Asn Gln Ala Phe Cys Phe Asp Phe 
            260                 265                 270         


Ala Phe Asp Glu Thr Ala Ser Asn Glu Val Val Tyr Arg Phe Thr Ala 
        275                 280                 285             


Arg Pro Leu Val Gln Thr Ile Phe Glu Gly Gly Lys Ala Thr Cys Phe 
    290                 295                 300                 


Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr His Thr Met Gly Gly Asp 
305                 310                 315                 320 


Leu Ser Gly Lys Ala Gln Asn Ala Ser Lys Gly Ile Tyr Ala Met Ala 
                325                 330                 335     


Ser Arg Asp Val Phe Leu Leu Lys Asn Gln Pro Cys Tyr Arg Lys Leu 
            340                 345                 350         


Gly Leu Glu Val Tyr Val Thr Phe Phe Glu Ile Tyr Asn Gly Lys Leu 
        355                 360                 365             


Phe Asp Leu Leu Asn Lys Lys Ala Lys Leu Arg Val Leu Glu Asp Gly 
    370                 375                 380                 


Lys Gln Gln Val Gln Val Val Gly Leu Gln Glu His Leu Val Asn Ser 
385                 390                 395                 400 


Ala Asp Asp Val Ile Lys Met Ile Asp Met Gly Ser Ala Cys Arg Thr 
                405                 410                 415     


Ser Gly Gln Thr Phe Ala Asn Ser Asn Ser Ser Arg Ser His Ala Cys 
            420                 425                 430         


Phe Gln Ile Ile Leu Arg Ala Lys Gly Arg Met His Gly Lys Phe Ser 
        435                 440                 445             


Leu Val Asp Leu Ala Gly Asn Glu Arg Gly Ala Asp Thr Ser Ser Ala 
    450                 455                 460                 


Asp Arg Gln Thr Arg Met Glu Gly Ala Glu Ile Asn Lys Ser Leu Leu 
465                 470                 475                 480 


Ala Leu Lys Glu Cys Ile Arg Ala Leu Gly Gln Asn Lys Ala His Thr 
                485                 490                 495     


Pro Phe Arg Glu Ser Lys Leu Thr Gln Val Leu Arg Asp Ser Phe Ile 
            500                 505                 510         


Gly Glu Asn Ser Arg Thr Cys Met Ile Ala Thr Ile Ser Pro Gly Ile 
        515                 520                 525             


Ser Ser Cys Glu Tyr Thr Leu Asn Thr Leu Arg Tyr Ala Asp Arg Val 
    530                 535                 540                 


Lys Glu Leu Ser Pro His Ser Gly Pro Ser Gly Glu Gln Leu Ile Gln 
545                 550                 555                 560 


Met Glu Thr Glu Glu Met Glu Ala Cys Ser Asn Gly Ala Leu Ile Pro 
                565                 570                 575     


Gly Asn Leu Ser Lys Glu Glu Glu Glu Leu Ser Ser Gln Met Ser Ser 
            580                 585                 590         


Phe Asn Glu Ala Met Thr Gln Ile Arg Glu Leu Glu Glu Lys Ala Met 
        595                 600                 605             


Glu Glu Leu Lys Glu Ile Ile Gln Gln Gly Pro Asp Trp Leu Glu Leu 
    610                 615                 620                 


Ser Glu Met Thr Glu Gln Pro Asp Tyr Asp Leu Glu Thr Phe Val Asn 
625                 630                 635                 640 


Lys Ala Glu Ser Ala Leu Ala Gln Gln Ala Lys His Phe Ser Ala Leu 
                645                 650                 655     


Arg Asp Val Ile Lys Ala Leu Arg Leu Ala Met Gln Leu Glu Glu Gln 
            660                 665                 670         


Ala Ser Arg Gln Ile Ser Ser Lys Lys Arg Pro Gln 
        675                 680                 


<210>  5890
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF3A__Homo_sapiens__NP_001287720

<400>  5890

Met Pro Ile Asn Lys Ser Glu Lys Pro Glu Ser Cys Asp Asn Val Lys 
1               5                   10                  15      


Val Val Val Arg Cys Arg Pro Leu Asn Glu Arg Glu Lys Ser Met Cys 
            20                  25                  30          


Tyr Lys Gln Ala Val Ser Val Asp Glu Met Arg Gly Thr Ile Thr Val 
        35                  40                  45              


His Lys Thr Asp Ser Ser Asn Glu Pro Pro Lys Thr Phe Thr Phe Asp 
    50                  55                  60                  


Thr Val Phe Gly Pro Glu Ser Lys Gln Leu Asp Val Tyr Asn Leu Thr 
65                  70                  75                  80  


Ala Arg Pro Ile Ile Asp Ser Val Leu Glu Gly Tyr Asn Gly Thr Ile 
                85                  90                  95      


Phe Ala Tyr Gly Gln Thr Gly Thr Gly Lys Thr Phe Thr Met Glu Gly 
            100                 105                 110         


Val Arg Ala Ile Pro Glu Leu Arg Gly Ile Ile Pro Asn Ser Phe Ala 
        115                 120                 125             


His Ile Phe Gly His Ile Ala Lys Ala Glu Gly Asp Thr Arg Phe Leu 
    130                 135                 140                 


Val Arg Val Ser Tyr Leu Glu Ile Tyr Asn Glu Glu Val Arg Asp Leu 
145                 150                 155                 160 


Leu Gly Lys Asp Gln Thr Gln Arg Leu Glu Val Lys Glu Arg Pro Asp 
                165                 170                 175     


Val Gly Val Tyr Ile Lys Asp Leu Ser Ala Tyr Val Val Asn Asn Ala 
            180                 185                 190         


Asp Asp Met Asp Arg Ile Met Thr Leu Gly His Lys Asn Arg Ser Val 
        195                 200                 205             


Gly Ala Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ala Ile Phe 
    210                 215                 220                 


Thr Ile Thr Ile Glu Cys Ser Glu Lys Gly Ile Asp Gly Asn Met His 
225                 230                 235                 240 


Val Arg Met Gly Lys Leu His Leu Val Asp Leu Ala Gly Ser Glu Arg 
                245                 250                 255     


Gln Ala Lys Thr Gly Ala Thr Gly Gln Arg Leu Lys Glu Ala Thr Lys 
            260                 265                 270         


Ile Asn Leu Ser Leu Ser Thr Leu Gly Asn Val Ile Ser Ala Leu Val 
        275                 280                 285             


Asp Gly Lys Ser Thr His Val Pro Tyr Arg Asn Ser Lys Leu Thr Arg 
    290                 295                 300                 


Leu Leu Gln Asp Ser Leu Gly Gly Asn Ser Lys Thr Met Met Cys Ala 
305                 310                 315                 320 


Asn Ile Gly Pro Ala Asp Tyr Asn Tyr Asp Glu Thr Ile Ser Thr Leu 
                325                 330                 335     


Arg Tyr Ala Asn Arg Ala Lys Asn Ile Lys Asn Lys Ala Arg Ile Asn 
            340                 345                 350         


Glu Asp Pro Lys Asp Ala Leu Leu Arg Gln Phe Gln Lys Glu Ile Glu 
        355                 360                 365             


Glu Leu Lys Lys Lys Leu Glu Glu Gly Glu Glu Ile Ser Gly Ser Asp 
    370                 375                 380                 


Ile Ser Gly Ser Glu Glu Asp Asp Asp Glu Glu Gly Glu Val Gly Glu 
385                 390                 395                 400 


Asp Gly Glu Lys Arg Lys Lys Arg Arg Gly Ser Ser Ser Ser Ser Ser 
                405                 410                 415     


Ser Asp Ser Thr Cys Ser Val Ile Glu Lys Pro Leu Asp Lys Phe Leu 
            420                 425                 430         


Pro Asn Gln Ala Gly Lys Lys Lys Val Ser Pro Asp Lys Met Ile Glu 
        435                 440                 445             


Met Gln Ala Lys Ile Asp Glu Glu Arg Lys Ala Leu Glu Thr Lys Leu 
    450                 455                 460                 


Asp Met Glu Glu Glu Glu Arg Asn Lys Ala Arg Ala Glu Leu Glu Lys 
465                 470                 475                 480 


Arg Glu Lys Asp Leu Leu Lys Ala Gln Gln Glu His Gln Ser Leu Leu 
                485                 490                 495     


Glu Lys Leu Ser Ala Leu Glu Lys Lys Val Ile Val Gly Gly Val Asp 
            500                 505                 510         


Leu Leu Ala Lys Ala Glu Glu Gln Glu Lys Leu Leu Glu Glu Ser Asn 
        515                 520                 525             


Met Glu Leu Glu Glu Arg Arg Lys Arg Ala Glu Gln Leu Arg Arg Glu 
    530                 535                 540                 


Leu Glu Glu Lys Glu Gln Glu Arg Leu Asp Ile Glu Glu Lys Tyr Thr 
545                 550                 555                 560 


Ser Leu Gln Glu Glu Ala Gln Gly Lys Thr Lys Lys Leu Lys Lys Val 
                565                 570                 575     


Trp Thr Met Leu Met Ala Ala Lys Ser Glu Met Ala Asp Leu Gln Gln 
            580                 585                 590         


Glu His Gln Arg Glu Ile Glu Gly Leu Leu Glu Asn Ile Arg Gln Leu 
        595                 600                 605             


Ser Arg Glu Leu Arg Leu Gln Met Leu Ile Ile Asp Asn Phe Ile Pro 
    610                 615                 620                 


Arg Asp Tyr Gln Glu Met Ile Glu Asn Tyr Val His Trp Asn Glu Asp 
625                 630                 635                 640 


Ile Gly Glu Trp Gln Leu Lys Cys Val Ala Tyr Thr Gly Asn Asn Met 
                645                 650                 655     


Arg Lys Gln Thr Pro Val Pro Asp Lys Lys Glu Lys Asp Pro Phe Glu 
            660                 665                 670         


Val Asp Leu Ser His Val Tyr Leu Ala Tyr Thr Glu Glu Ser Leu Arg 
        675                 680                 685             


Gln Ser Leu Met Lys Leu Glu Arg Pro Arg Thr Ser Lys Gly Lys Ala 
    690                 695                 700                 


Arg Pro Lys Thr Gly Arg Arg Lys Arg Ser Ala Lys Pro Glu Thr Val 
705                 710                 715                 720 


Ile Asp Ser Leu Leu Gln 
                725     


<210>  5891
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF3B__Homo_sapiens__NP_004789

<400>  5891

Met Ser Lys Leu Lys Ser Ser Glu Ser Val Arg Val Val Val Arg Cys 
1               5                   10                  15      


Arg Pro Met Asn Gly Lys Glu Lys Ala Ala Ser Tyr Asp Lys Val Val 
            20                  25                  30          


Asp Val Asp Val Lys Leu Gly Gln Val Ser Val Lys Asn Pro Lys Gly 
        35                  40                  45              


Thr Ala His Glu Met Pro Lys Thr Phe Thr Phe Asp Ala Val Tyr Asp 
    50                  55                  60                  


Trp Asn Ala Lys Gln Phe Glu Leu Tyr Asp Glu Thr Phe Arg Pro Leu 
65                  70                  75                  80  


Val Asp Ser Val Leu Gln Gly Phe Asn Gly Thr Ile Phe Ala Tyr Gly 
                85                  90                  95      


Gln Thr Gly Thr Gly Lys Thr Tyr Thr Met Glu Gly Ile Arg Gly Asp 
            100                 105                 110         


Pro Glu Lys Arg Gly Val Ile Pro Asn Ser Phe Asp His Ile Phe Thr 
        115                 120                 125             


His Ile Ser Arg Ser Gln Asn Gln Gln Tyr Leu Val Arg Ala Ser Tyr 
    130                 135                 140                 


Leu Glu Ile Tyr Gln Glu Glu Ile Arg Asp Leu Leu Ser Lys Asp Gln 
145                 150                 155                 160 


Thr Lys Arg Leu Glu Leu Lys Glu Arg Pro Asp Thr Gly Val Tyr Val 
                165                 170                 175     


Lys Asp Leu Ser Ser Phe Val Thr Lys Ser Val Lys Glu Ile Glu His 
            180                 185                 190         


Val Met Asn Val Gly Asn Gln Asn Arg Ser Val Gly Ala Thr Asn Met 
        195                 200                 205             


Asn Glu His Ser Ser Arg Ser His Ala Ile Phe Val Ile Thr Ile Glu 
    210                 215                 220                 


Cys Ser Glu Val Gly Leu Asp Gly Glu Asn His Ile Arg Val Gly Lys 
225                 230                 235                 240 


Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln Ala Lys Thr Gly 
                245                 250                 255     


Ala Gln Gly Glu Arg Leu Lys Glu Ala Thr Lys Ile Asn Leu Ser Leu 
            260                 265                 270         


Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Val Asp Gly Lys Ser Thr 
        275                 280                 285             


His Ile Pro Tyr Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser 
    290                 295                 300                 


Leu Gly Gly Asn Ala Lys Thr Val Met Val Ala Asn Val Gly Pro Ala 
305                 310                 315                 320 


Ser Tyr Asn Val Glu Glu Thr Leu Thr Thr Leu Arg Tyr Ala Asn Arg 
                325                 330                 335     


Ala Lys Asn Ile Lys Asn Lys Pro Arg Val Asn Glu Asp Pro Lys Asp 
            340                 345                 350         


Ala Leu Leu Arg Glu Phe Gln Glu Glu Ile Ala Arg Leu Lys Ala Gln 
        355                 360                 365             


Leu Glu Lys Arg Ser Ile Gly Arg Arg Lys Arg Arg Glu Lys Arg Arg 
    370                 375                 380                 


Glu Gly Gly Gly Ser Gly Gly Gly Gly Glu Glu Glu Glu Glu Glu Gly 
385                 390                 395                 400 


Glu Glu Gly Glu Glu Glu Gly Asp Asp Lys Asp Asp Tyr Trp Arg Glu 
                405                 410                 415     


Gln Gln Glu Lys Leu Glu Ile Glu Lys Arg Ala Ile Val Glu Asp His 
            420                 425                 430         


Ser Leu Val Ala Glu Glu Lys Met Arg Leu Leu Lys Glu Lys Glu Lys 
        435                 440                 445             


Lys Met Glu Asp Leu Arg Arg Glu Lys Asp Ala Ala Glu Met Leu Gly 
    450                 455                 460                 


Ala Lys Ile Lys Ala Met Glu Ser Lys Leu Leu Val Gly Gly Lys Asn 
465                 470                 475                 480 


Ile Val Asp His Thr Asn Glu Gln Gln Lys Ile Leu Glu Gln Lys Arg 
                485                 490                 495     


Gln Glu Ile Ala Glu Gln Lys Arg Arg Glu Arg Glu Ile Gln Gln Gln 
            500                 505                 510         


Met Glu Ser Arg Asp Glu Glu Thr Leu Glu Leu Lys Glu Thr Tyr Ser 
        515                 520                 525             


Ser Leu Gln Gln Glu Val Asp Ile Lys Thr Lys Lys Leu Lys Lys Leu 
    530                 535                 540                 


Phe Ser Lys Leu Gln Ala Val Lys Ala Glu Ile His Asp Leu Gln Glu 
545                 550                 555                 560 


Glu His Ile Lys Glu Arg Gln Glu Leu Glu Gln Thr Gln Asn Glu Leu 
                565                 570                 575     


Thr Arg Glu Leu Lys Leu Lys His Leu Ile Ile Glu Asn Phe Ile Pro 
            580                 585                 590         


Leu Glu Glu Lys Ser Lys Ile Met Asn Arg Ala Phe Phe Asp Glu Glu 
        595                 600                 605             


Glu Asp His Trp Lys Leu His Pro Ile Thr Arg Leu Glu Asn Gln Gln 
    610                 615                 620                 


Met Met Lys Arg Pro Val Ser Ala Val Gly Tyr Lys Arg Pro Leu Ser 
625                 630                 635                 640 


Gln His Ala Arg Met Ser Met Met Ile Arg Pro Glu Ala Arg Tyr Arg 
                645                 650                 655     


Ala Glu Asn Ile Val Leu Leu Glu Leu Asp Met Pro Ser Arg Thr Thr 
            660                 665                 670         


Arg Asp Tyr Glu Gly Pro Ala Ile Ala Pro Lys Val Gln Ala Ala Leu 
        675                 680                 685             


Asp Ala Ala Leu Gln Asp Glu Asp Glu Ile Gln Val Asp Ala Ser Ser 
    690                 695                 700                 


Phe Glu Ser Thr Ala Asn Lys Lys Ser Lys Ala Arg Pro Lys Ser Gly 
705                 710                 715                 720 


Arg Lys Ser Gly Ser Ser Ser Ser Ser Ser Gly Thr Pro Ala Ser Gln 
                725                 730                 735     


Leu Tyr Pro Gln Ser Arg Gly Leu Val Pro Lys 
            740                 745         


<210>  5892
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF3C__Homo_sapiens__NP_002245

<400>  5892

Met Ala Ser Lys Thr Lys Ala Ser Glu Ala Leu Lys Val Val Ala Arg 
1               5                   10                  15      


Cys Arg Pro Leu Ser Arg Lys Glu Glu Ala Ala Gly His Glu Gln Ile 
            20                  25                  30          


Leu Thr Met Asp Val Lys Leu Gly Gln Val Thr Leu Arg Asn Pro Arg 
        35                  40                  45              


Ala Ala Pro Gly Glu Leu Pro Lys Thr Phe Thr Phe Asp Ala Val Tyr 
    50                  55                  60                  


Asp Ala Ser Ser Lys Gln Ala Asp Leu Tyr Asp Glu Thr Val Arg Pro 
65                  70                  75                  80  


Leu Ile Asp Ser Val Leu Gln Gly Phe Asn Gly Thr Val Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Thr Gly Lys Thr Tyr Thr Met Gln Gly Thr Trp Val 
            100                 105                 110         


Glu Pro Glu Leu Arg Gly Val Ile Pro Asn Ala Phe Glu His Ile Phe 
        115                 120                 125             


Thr His Ile Ser Arg Ser Gln Asn Gln Gln Tyr Leu Val Arg Ala Ser 
    130                 135                 140                 


Tyr Leu Glu Ile Tyr Gln Glu Glu Ile Arg Asp Leu Leu Ser Lys Glu 
145                 150                 155                 160 


Pro Gly Lys Arg Leu Glu Leu Lys Glu Asn Pro Glu Thr Gly Val Tyr 
                165                 170                 175     


Ile Lys Asp Leu Ser Ser Phe Val Thr Lys Asn Val Lys Glu Ile Glu 
            180                 185                 190         


His Val Met Asn Leu Gly Asn Gln Thr Arg Ala Val Gly Ser Thr His 
        195                 200                 205             


Met Asn Glu Val Ser Ser Arg Ser His Ala Ile Phe Ile Ile Thr Val 
    210                 215                 220                 


Glu Cys Ser Glu Arg Gly Ser Asp Gly Gln Asp His Ile Arg Val Gly 
225                 230                 235                 240 


Lys Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Gln Asn Lys Ala 
                245                 250                 255     


Gly Pro Asn Thr Ala Gly Gly Ala Ala Thr Pro Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Ser Gly Gly Gly Ala Gly Gly Glu Arg Pro Lys 
        275                 280                 285             


Glu Ala Ser Lys Ile Asn Leu Ser Leu Ser Ala Leu Gly Asn Val Ile 
    290                 295                 300                 


Ala Ala Leu Ala Gly Asn Arg Ser Thr His Ile Pro Tyr Arg Asp Ser 
305                 310                 315                 320 


Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Ala Lys Thr 
                325                 330                 335     


Ile Met Val Ala Thr Leu Gly Pro Ala Ser His Ser Tyr Asp Glu Ser 
            340                 345                 350         


Leu Ser Thr Leu Arg Phe Ala Asn Arg Ala Lys Asn Ile Lys Asn Lys 
        355                 360                 365             


Pro Arg Val Asn Glu Asp Pro Lys Asp Thr Leu Leu Arg Glu Phe Gln 
    370                 375                 380                 


Glu Glu Ile Ala Arg Leu Lys Ala Gln Leu Glu Lys Arg Gly Met Leu 
385                 390                 395                 400 


Gly Lys Arg Pro Arg Arg Lys Ser Ser Arg Arg Lys Lys Ala Val Ser 
                405                 410                 415     


Ala Pro Pro Gly Tyr Pro Glu Gly Pro Val Ile Glu Ala Trp Val Ala 
            420                 425                 430         


Glu Glu Glu Asp Asp Asn Asn Asn Asn His Arg Pro Pro Gln Pro Ile 
        435                 440                 445             


Leu Glu Ser Ala Leu Glu Lys Asn Met Glu Asn Tyr Leu Gln Glu Gln 
    450                 455                 460                 


Lys Glu Arg Leu Glu Glu Glu Lys Ala Ala Ile Gln Asp Asp Arg Ser 
465                 470                 475                 480 


Leu Val Ser Glu Glu Lys Gln Lys Leu Leu Glu Glu Lys Glu Lys Met 
                485                 490                 495     


Leu Glu Asp Leu Arg Arg Glu Gln Gln Ala Thr Glu Leu Leu Ala Ala 
            500                 505                 510         


Lys Tyr Lys Ala Met Glu Ser Lys Leu Leu Ile Gly Gly Arg Asn Ile 
        515                 520                 525             


Met Asp His Thr Asn Glu Gln Gln Lys Met Leu Glu Leu Lys Arg Gln 
    530                 535                 540                 


Glu Ile Ala Glu Gln Lys Arg Arg Glu Arg Glu Met Gln Gln Glu Met 
545                 550                 555                 560 


Met Leu Arg Asp Glu Glu Thr Met Glu Leu Arg Gly Thr Tyr Thr Ser 
                565                 570                 575     


Leu Gln Gln Glu Val Glu Val Lys Thr Lys Lys Leu Lys Lys Leu Tyr 
            580                 585                 590         


Ala Lys Leu Gln Ala Val Lys Ala Glu Ile Gln Asp Gln His Asp Glu 
        595                 600                 605             


Tyr Ile Arg Val Arg Gln Asp Leu Glu Glu Ala Gln Asn Glu Gln Thr 
    610                 615                 620                 


Arg Glu Leu Lys Leu Lys Tyr Leu Ile Ile Glu Asn Phe Ile Pro Pro 
625                 630                 635                 640 


Glu Glu Lys Asn Lys Ile Met Asn Arg Leu Phe Leu Asp Cys Glu Glu 
                645                 650                 655     


Glu Gln Trp Lys Phe Gln Pro Leu Val Pro Ala Gly Val Ser Ser Ser 
            660                 665                 670         


Gln Met Lys Lys Arg Pro Thr Ser Ala Val Gly Tyr Lys Arg Pro Ile 
        675                 680                 685             


Ser Gln Tyr Ala Arg Val Ala Met Ala Met Gly Ser His Pro Arg Tyr 
    690                 695                 700                 


Arg Ala Glu Asn Ile Met Phe Leu Glu Leu Asp Val Ser Pro Pro Ala 
705                 710                 715                 720 


Val Phe Glu Met Glu Phe Ser His Asp Gln Glu Gln Asp Pro Arg Ala 
                725                 730                 735     


Leu His Met Glu Arg Leu Met Arg Leu Asp Ser Phe Leu Glu Arg Pro 
            740                 745                 750         


Ser Thr Ser Lys Val Arg Lys Ser Arg Ser Trp Cys Gln Ser Pro Gln 
        755                 760                 765             


Arg Pro Pro Pro Ser Thr Thr His Ala Ser Leu Ala Ser Ala Ser Leu 
    770                 775                 780                 


Arg Pro Ala Thr Val Ala Asp His Glu 
785                 790             


<210>  5893
<211>  1232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF4A__Homo_sapiens__XP_011529195

<400>  5893

Met Lys Glu Glu Val Lys Gly Ile Pro Val Arg Val Ala Leu Arg Cys 
1               5                   10                  15      


Arg Pro Leu Val Pro Lys Glu Ile Ser Glu Gly Cys Gln Met Cys Leu 
            20                  25                  30          


Ser Phe Val Pro Gly Glu Pro Gln Val Val Val Gly Thr Asp Lys Ser 
        35                  40                  45              


Phe Thr Tyr Asp Phe Val Phe Asp Pro Ser Thr Glu Gln Glu Glu Val 
    50                  55                  60                  


Phe Asn Thr Ala Val Ala Pro Leu Ile Lys Gly Val Phe Lys Gly Tyr 
65                  70                  75                  80  


Asn Ala Thr Val Leu Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr Tyr 
                85                  90                  95      


Ser Met Gly Gly Ala Tyr Thr Ala Glu Gln Glu Asn Glu Pro Thr Val 
            100                 105                 110         


Gly Val Ile Pro Arg Val Ile Gln Leu Leu Phe Lys Glu Ile Asp Lys 
        115                 120                 125             


Lys Ser Asp Phe Glu Phe Thr Leu Lys Val Ser Tyr Leu Glu Ile Tyr 
    130                 135                 140                 


Asn Glu Glu Ile Leu Asp Leu Leu Cys Pro Ser Arg Glu Lys Ala Gln 
145                 150                 155                 160 


Ile Asn Ile Arg Glu Asp Pro Lys Glu Gly Ile Lys Ile Val Gly Leu 
                165                 170                 175     


Thr Glu Lys Thr Val Leu Val Ala Leu Asp Thr Val Ser Cys Leu Glu 
            180                 185                 190         


Gln Gly Asn Asn Ser Arg Thr Val Ala Ser Thr Ala Met Asn Ser Gln 
        195                 200                 205             


Ser Ser Arg Ser His Ala Ile Phe Thr Ile Ser Leu Glu Gln Arg Lys 
    210                 215                 220                 


Lys Ser Asp Lys Asn Ser Ser Phe Arg Ser Lys Leu His Leu Val Asp 
225                 230                 235                 240 


Leu Ala Gly Ser Glu Arg Gln Lys Lys Thr Lys Ala Glu Gly Asp Arg 
                245                 250                 255     


Leu Lys Glu Gly Ile Asn Ile Asn Arg Gly Leu Leu Cys Leu Gly Asn 
            260                 265                 270         


Val Ile Ser Ala Leu Gly Asp Asp Lys Lys Gly Gly Phe Val Pro Tyr 
        275                 280                 285             


Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn 
    290                 295                 300                 


Ser His Thr Leu Met Ile Ala Cys Val Ser Pro Ala Asp Ser Asn Leu 
305                 310                 315                 320 


Glu Glu Thr Leu Asn Thr Leu Arg Tyr Ala Asp Arg Ala Arg Lys Ile 
                325                 330                 335     


Lys Asn Lys Pro Ile Val Asn Ile Asp Pro Gln Thr Ala Glu Leu Asn 
            340                 345                 350         


His Leu Lys Gln Gln Val Gln Gln Leu Gln Val Leu Leu Leu Gln Ala 
        355                 360                 365             


His Gly Gly Thr Leu Pro Gly Ser Ile Thr Val Glu Pro Ser Glu Asn 
    370                 375                 380                 


Leu Gln Ser Leu Met Glu Lys Asn Gln Ser Leu Val Glu Glu Asn Glu 
385                 390                 395                 400 


Lys Leu Ser Arg Gly Leu Ser Glu Ala Ala Gly Gln Thr Ala Gln Met 
                405                 410                 415     


Leu Glu Arg Ile Ile Leu Thr Glu Gln Ala Asn Glu Lys Met Asn Ala 
            420                 425                 430         


Lys Leu Glu Glu Leu Arg Gln His Ala Ala Cys Lys Leu Asp Leu Gln 
        435                 440                 445             


Lys Leu Val Glu Thr Leu Glu Asp Gln Glu Leu Lys Glu Asn Val Glu 
    450                 455                 460                 


Ile Ile Cys Asn Leu Gln Gln Leu Ile Thr Gln Leu Ser Asp Glu Thr 
465                 470                 475                 480 


Val Ala Cys Met Ala Ala Ala Ile Asp Thr Ala Val Glu Gln Glu Ala 
                485                 490                 495     


Gln Val Glu Thr Ser Pro Glu Thr Ser Arg Ser Ser Asp Ala Phe Thr 
            500                 505                 510         


Thr Gln His Ala Leu Arg Gln Ala Gln Met Ser Lys Glu Leu Val Glu 
        515                 520                 525             


Leu Asn Lys Ala Leu Ala Leu Lys Glu Ala Leu Ala Arg Lys Met Thr 
    530                 535                 540                 


Gln Asn Asp Ser Gln Leu Gln Pro Ile Gln Tyr Gln Tyr Gln Asp Asn 
545                 550                 555                 560 


Ile Lys Glu Leu Glu Leu Glu Val Ile Asn Leu Gln Lys Glu Lys Glu 
                565                 570                 575     


Glu Leu Val Leu Glu Leu Gln Thr Ala Lys Lys Asp Ala Asn Gln Ala 
            580                 585                 590         


Lys Leu Ser Glu Arg Arg Arg Lys Arg Leu Gln Glu Leu Glu Gly Gln 
        595                 600                 605             


Ile Ala Asp Leu Lys Lys Lys Leu Asn Glu Gln Ser Lys Leu Leu Lys 
    610                 615                 620                 


Leu Lys Glu Ser Thr Glu Arg Thr Val Ser Lys Leu Asn Gln Glu Ile 
625                 630                 635                 640 


Arg Met Met Lys Asn Gln Arg Val Gln Leu Met Arg Gln Met Lys Glu 
                645                 650                 655     


Asp Ala Glu Lys Phe Arg Gln Trp Lys Gln Lys Lys Asp Lys Glu Val 
            660                 665                 670         


Ile Gln Leu Lys Glu Arg Asp Arg Lys Arg Gln Tyr Glu Leu Leu Lys 
        675                 680                 685             


Leu Glu Arg Asn Phe Gln Lys Gln Ser Asn Val Leu Arg Arg Lys Thr 
    690                 695                 700                 


Glu Glu Ala Ala Ala Ala Asn Lys Arg Leu Lys Asp Ala Leu Gln Lys 
705                 710                 715                 720 


Gln Arg Glu Val Ala Asp Lys Arg Lys Glu Thr Gln Ser Arg Gly Met 
                725                 730                 735     


Glu Gly Thr Ala Ala Arg Val Lys Asn Trp Leu Gly Asn Glu Ile Glu 
            740                 745                 750         


Val Met Val Ser Thr Glu Glu Ala Lys Arg His Leu Asn Asp Leu Leu 
        755                 760                 765             


Glu Asp Arg Lys Ile Leu Ala Gln Asp Val Ala Gln Leu Lys Glu Lys 
    770                 775                 780                 


Lys Glu Ser Gly Glu Asn Pro Pro Pro Lys Leu Arg Arg Arg Thr Phe 
785                 790                 795                 800 


Ser Leu Thr Glu Val Arg Gly Gln Val Ser Glu Ser Glu Asp Ser Ile 
                805                 810                 815     


Thr Lys Gln Ile Glu Ser Leu Glu Thr Glu Met Glu Phe Arg Ser Ala 
            820                 825                 830         


Gln Ile Ala Asp Leu Gln Gln Lys Leu Leu Asp Ala Glu Ser Glu Asp 
        835                 840                 845             


Arg Pro Lys Gln Arg Trp Glu Asn Ile Ala Thr Ile Leu Glu Ala Lys 
    850                 855                 860                 


Cys Ala Leu Lys Tyr Leu Ile Gly Glu Leu Val Ser Ser Lys Ile Gln 
865                 870                 875                 880 


Val Ser Lys Leu Glu Ser Ser Leu Lys Gln Ser Lys Thr Ser Cys Ala 
                885                 890                 895     


Asp Met Gln Lys Met Leu Phe Glu Glu Arg Asn His Phe Ala Glu Ile 
            900                 905                 910         


Glu Thr Glu Leu Gln Ala Glu Leu Val Arg Met Glu Gln Gln His Gln 
        915                 920                 925             


Glu Lys Val Leu Tyr Leu Leu Ser Gln Leu Gln Gln Ser Gln Met Ala 
    930                 935                 940                 


Glu Lys Gln Leu Glu Glu Ser Val Ser Glu Lys Glu Gln Gln Leu Leu 
945                 950                 955                 960 


Ser Thr Leu Lys Cys Gln Asp Glu Glu Leu Glu Lys Met Arg Glu Val 
                965                 970                 975     


Cys Glu Gln Asn Gln Gln Leu Leu Arg Glu Asn Glu Ile Ile Lys Gln 
            980                 985                 990         


Lys Leu Thr Leu Leu Gln Val Ala  Ser Arg Gln Lys His  Leu Pro Lys 
        995                 1000                 1005             


Asp Thr  Leu Leu Ser Pro Asp  Ser Ser Phe Glu Tyr  Val Pro Pro 
    1010                 1015                 1020             


Lys Pro  Lys Pro Ser Arg Val  Lys Glu Lys Phe Leu  Glu Gln Ser 
    1025                 1030                 1035             


Met Asp  Ile Glu Asp Leu Lys  Tyr Cys Ser Glu His  Ser Val Asn 
    1040                 1045                 1050             


Glu His  Glu Asp Gly Asp Gly  Asp Asp Asp Glu Gly  Asp Asp Glu 
    1055                 1060                 1065             


Glu Trp  Lys Pro Thr Lys Leu  Val Lys Val Ser Arg  Lys Asn Ile 
    1070                 1075                 1080             


Gln Gly  Cys Ser Cys Lys Gly  Trp Cys Gly Asn Lys  Gln Cys Gly 
    1085                 1090                 1095             


Cys Arg  Lys Gln Lys Ser Asp  Cys Gly Val Asp Cys  Cys Cys Asp 
    1100                 1105                 1110             


Pro Thr  Lys Cys Arg Asn Arg  Gln Gln Gly Lys Asp  Ser Leu Gly 
    1115                 1120                 1125             


Thr Val  Glu Arg Thr Gln Asp  Ser Glu Gly Ser Phe  Lys Leu Glu 
    1130                 1135                 1140             


Asp Pro  Thr Glu Val Thr Pro  Gly Leu Ser Phe Phe  Asn Pro Val 
    1145                 1150                 1155             


Cys Ala  Thr Pro Asn Ser Lys  Ile Leu Lys Glu Met  Cys Asp Val 
    1160                 1165                 1170             


Glu Gln  Val Leu Ser Lys Lys  Thr Pro Pro Ala Pro  Ser Pro Phe 
    1175                 1180                 1185             


Asp Leu  Pro Glu Leu Lys His  Val Ala Thr Glu Tyr  Gln Glu Asn 
    1190                 1195                 1200             


Lys Ala  Pro Gly Lys Lys Lys  Lys Arg Ala Leu Ala  Ser Asn Thr 
    1205                 1210                 1215             


Ser Phe  Phe Ser Gly Cys Ser  Pro Ile Glu Glu Glu  Ala His 
    1220                 1225                 1230         


<210>  5894
<211>  1234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF4B__Homo_sapiens__NP_001092763

<400>  5894

Met Lys Glu Glu Val Lys Gly Ile Pro Val Arg Val Ala Leu Arg Cys 
1               5                   10                  15      


Arg Pro Leu Val Pro Lys Glu Ile Ser Glu Gly Cys Gln Met Cys Leu 
            20                  25                  30          


Ser Phe Val Pro Gly Glu Thr Gln Val Val Val Gly Thr Asp Lys Ser 
        35                  40                  45              


Phe Thr Tyr Asp Phe Val Phe Asp Pro Cys Thr Glu Gln Glu Glu Val 
    50                  55                  60                  


Phe Asn Lys Ala Val Ala Pro Leu Ile Lys Gly Ile Phe Lys Gly Tyr 
65                  70                  75                  80  


Asn Ala Thr Val Leu Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr Tyr 
                85                  90                  95      


Ser Met Gly Gly Ala Tyr Thr Ala Glu Gln Glu Asn Glu Pro Thr Val 
            100                 105                 110         


Gly Ile Ile Pro Arg Val Ile Gln Leu Leu Phe Lys Glu Ile Asp Lys 
        115                 120                 125             


Lys Ser Asp Phe Glu Phe Thr Leu Lys Val Ser Tyr Leu Glu Ile Tyr 
    130                 135                 140                 


Asn Glu Glu Ile Leu Asp Leu Leu Cys Pro Ser Arg Glu Lys Ala Gln 
145                 150                 155                 160 


Ile Asn Ile Arg Glu Asp Pro Lys Glu Gly Ile Lys Ile Val Gly Leu 
                165                 170                 175     


Thr Glu Lys Thr Val Leu Val Ala Leu Asp Thr Val Ser Cys Leu Glu 
            180                 185                 190         


Gln Gly Asn Asn Ser Arg Thr Val Ala Ser Thr Ala Met Asn Ser Gln 
        195                 200                 205             


Ser Ser Arg Ser His Ala Ile Phe Thr Ile Ser Ile Glu Gln Arg Lys 
    210                 215                 220                 


Lys Ser Asp Lys Asn Cys Ser Phe Arg Ser Lys Leu His Leu Val Asp 
225                 230                 235                 240 


Leu Ala Gly Ser Glu Arg Gln Lys Lys Thr Lys Ala Glu Gly Asp Arg 
                245                 250                 255     


Leu Lys Glu Gly Ile Asn Ile Asn Arg Gly Leu Leu Cys Leu Gly Asn 
            260                 265                 270         


Val Ile Ser Ala Leu Gly Asp Asp Lys Lys Gly Ser Phe Val Pro Tyr 
        275                 280                 285             


Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn 
    290                 295                 300                 


Ser His Thr Leu Met Ile Ala Cys Val Ser Pro Ala Asp Ser Asn Leu 
305                 310                 315                 320 


Glu Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Arg Lys Ile 
                325                 330                 335     


Lys Asn Lys Pro Ile Val Asn Ile Asp Pro His Thr Ala Glu Leu Asn 
            340                 345                 350         


His Leu Lys Gln Gln Val Gln Gln Leu Gln Val Leu Leu Leu Gln Ala 
        355                 360                 365             


His Gly Gly Thr Leu Pro Gly Ser Ile Asn Ala Glu Pro Ser Glu Asn 
    370                 375                 380                 


Leu Gln Ser Leu Met Glu Lys Asn Gln Ser Leu Val Glu Glu Asn Glu 
385                 390                 395                 400 


Lys Leu Ser Arg Cys Leu Ser Lys Ala Ala Gly Gln Thr Ala Gln Met 
                405                 410                 415     


Leu Glu Arg Ile Ile Leu Thr Glu Gln Val Asn Glu Lys Leu Asn Ala 
            420                 425                 430         


Lys Leu Glu Glu Leu Arg Gln His Val Ala Cys Lys Leu Asp Leu Gln 
        435                 440                 445             


Lys Leu Val Glu Thr Leu Glu Asp Gln Glu Leu Lys Glu Asn Val Glu 
    450                 455                 460                 


Ile Ile Cys Asn Leu Gln Gln Leu Ile Thr Gln Leu Ser Asp Glu Thr 
465                 470                 475                 480 


Val Ala Cys Thr Ala Ala Ala Ile Asp Thr Ala Val Glu Glu Glu Ala 
                485                 490                 495     


Gln Val Glu Thr Ser Pro Glu Thr Ser Arg Ser Ser Asp Ala Phe Thr 
            500                 505                 510         


Thr Gln His Ala Leu His Gln Ala Gln Met Ser Lys Glu Val Val Glu 
        515                 520                 525             


Leu Asn Asn Ala Leu Ala Leu Lys Glu Ala Leu Val Arg Lys Met Thr 
    530                 535                 540                 


Gln Asn Asp Asn Gln Leu Gln Pro Ile Gln Phe Gln Tyr Gln Asp Asn 
545                 550                 555                 560 


Ile Lys Asn Leu Glu Leu Glu Val Ile Asn Leu Gln Lys Glu Lys Glu 
                565                 570                 575     


Glu Leu Val Arg Glu Leu Gln Thr Ala Lys Lys Asn Val Asn Gln Ala 
            580                 585                 590         


Lys Leu Ser Glu His Arg His Lys Leu Leu Gln Glu Leu Glu Gly Gln 
        595                 600                 605             


Ile Ala Asp Leu Lys Lys Lys Leu Asn Glu Gln Ser Lys Leu Leu Lys 
    610                 615                 620                 


Leu Lys Glu Ser Thr Glu Arg Thr Val Ser Lys Leu Asn Gln Glu Ile 
625                 630                 635                 640 


Trp Met Met Lys Asn Gln Arg Val Gln Leu Met Arg Gln Met Lys Glu 
                645                 650                 655     


Asp Ala Glu Lys Phe Arg Gln Trp Lys Gln Lys Lys Asp Lys Glu Val 
            660                 665                 670         


Ile Gln Leu Lys Glu Arg Asp Arg Lys Arg Gln Tyr Glu Leu Leu Lys 
        675                 680                 685             


Leu Glu Arg Asn Phe Gln Lys Gln Ser Ser Val Leu Arg Arg Lys Thr 
    690                 695                 700                 


Glu Glu Ala Ala Ala Ala Asn Lys Arg Leu Lys Asp Ala Leu Gln Lys 
705                 710                 715                 720 


Gln Arg Glu Val Thr Asp Lys Arg Lys Glu Thr Gln Ser His Gly Lys 
                725                 730                 735     


Glu Gly Ile Ala Ala Arg Val Arg Asn Trp Leu Gly Asn Glu Ile Glu 
            740                 745                 750         


Val Met Val Ser Thr Glu Glu Ala Lys Arg His Leu Asn Asp Leu Leu 
        755                 760                 765             


Glu Asp Arg Lys Ile Leu Ala Gln Asp Val Val Gln Leu Lys Glu Lys 
    770                 775                 780                 


Lys Glu Ser Arg Glu Asn Pro Pro Pro Lys Leu Arg Lys Cys Thr Phe 
785                 790                 795                 800 


Ser Leu Ser Glu Val His Gly Gln Val Leu Glu Ser Glu Asp Cys Ile 
                805                 810                 815     


Thr Lys Gln Ile Glu Ser Leu Glu Thr Glu Met Glu Leu Arg Ser Ala 
            820                 825                 830         


Gln Ile Ala Asp Leu Gln Gln Lys Leu Leu Asp Ala Glu Ser Glu Asp 
        835                 840                 845             


Arg Pro Lys Gln Cys Trp Glu Asn Ile Ala Thr Ile Leu Glu Ala Lys 
    850                 855                 860                 


Cys Ala Leu Lys Tyr Leu Ile Gly Glu Leu Val Ser Ser Lys Ile His 
865                 870                 875                 880 


Val Thr Lys Leu Glu Asn Ser Leu Arg Gln Ser Lys Ala Ser Cys Ala 
                885                 890                 895     


Asp Met Gln Lys Met Leu Phe Glu Glu Gln Asn His Phe Ser Glu Ile 
            900                 905                 910         


Glu Thr Glu Leu Gln Ala Glu Leu Val Arg Met Glu Gln Gln His Gln 
        915                 920                 925             


Glu Lys Val Leu Tyr Leu Val Ser Gln Leu Gln Glu Ser Gln Met Ala 
    930                 935                 940                 


Glu Lys Gln Leu Glu Lys Ser Ala Ser Glu Lys Glu Gln Gln Leu Val 
945                 950                 955                 960 


Ser Thr Leu Gln Cys Gln Asp Glu Glu Leu Glu Lys Met Arg Glu Val 
                965                 970                 975     


Cys Glu Gln Asn Gln Gln Leu Leu Gln Glu Asn Glu Ile Ile Lys Gln 
            980                 985                 990         


Lys Leu Ile Leu Leu Gln Val Ala  Ser Arg Gln Lys His  Leu Pro Asn 
        995                 1000                 1005             


Asp Thr  Leu Leu Ser Pro Asp  Ser Ser Phe Glu Tyr  Ile Pro Pro 
    1010                 1015                 1020             


Lys Pro  Lys Pro Ser Arg Val  Lys Glu Lys Phe Leu  Glu Gln Ser 
    1025                 1030                 1035             


Met Asp  Ile Glu Asp Leu Lys  Tyr Cys Ser Glu His  Ser Val Asn 
    1040                 1045                 1050             


Glu His  Glu Asp Gly Asp Gly  Asp Gly Asp Ser Asp  Glu Gly Asp 
    1055                 1060                 1065             


Asp Glu  Glu Trp Lys Pro Thr  Lys Leu Val Lys Val  Ser Arg Lys 
    1070                 1075                 1080             


Asn Ile  Gln Gly Cys Ser Cys  Lys Gly Trp Cys Gly  Asn Lys Gln 
    1085                 1090                 1095             


Cys Gly  Cys Arg Lys Gln Lys  Ser Asp Cys Gly Val  Asp Cys Ser 
    1100                 1105                 1110             


Cys Asp  Pro Thr Lys Cys Arg  Asn Arg Gln Gln Gly  Lys Asp Ser 
    1115                 1120                 1125             


Leu Gly  Thr Val Glu Gln Thr  Gln Asp Ser Glu Gly  Ser Phe Lys 
    1130                 1135                 1140             


Leu Glu  Asp Pro Thr Glu Val  Thr Pro Gly Leu Ser  Phe Phe Asn 
    1145                 1150                 1155             


Pro Val  Cys Ala Thr Pro Asn  Ser Lys Ile Leu Lys  Glu Met Cys 
    1160                 1165                 1170             


Asp Met  Glu Gln Val Leu Ser  Lys Lys Thr Ala Pro  Ala Pro Ser 
    1175                 1180                 1185             


Pro Phe  Asp Leu Pro Glu Ser  Lys His Gly Ala Thr  Glu Tyr Gln 
    1190                 1195                 1200             


Gln Asn  Lys Pro Pro Gly Lys  Lys Lys Lys Arg Ala  Leu Ala Ser 
    1205                 1210                 1215             


Asn Thr  Ser Phe Phe Ser Gly  Cys Ser Pro Ile Glu  Glu Glu Ala 
    1220                 1225                 1230             


His 
    


<210>  5895
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF5A__Homo_sapiens__NP_004975

<400>  5895

Met Ala Glu Thr Asn Asn Glu Cys Ser Ile Lys Val Leu Cys Arg Phe 
1               5                   10                  15      


Arg Pro Leu Asn Gln Ala Glu Ile Leu Arg Gly Asp Lys Phe Ile Pro 
            20                  25                  30          


Ile Phe Gln Gly Asp Asp Ser Val Val Ile Gly Gly Lys Pro Tyr Val 
        35                  40                  45              


Phe Asp Arg Val Phe Pro Pro Asn Thr Thr Gln Glu Gln Val Tyr His 
    50                  55                  60                  


Ala Cys Ala Met Gln Ile Val Lys Asp Val Leu Ala Gly Tyr Asn Gly 
65                  70                  75                  80  


Thr Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met 
                85                  90                  95      


Glu Gly Lys Leu His Asp Pro Gln Leu Met Gly Ile Ile Pro Arg Ile 
            100                 105                 110         


Ala Arg Asp Ile Phe Asn His Ile Tyr Ser Met Asp Glu Asn Leu Glu 
        115                 120                 125             


Phe His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Thr Lys Thr Asn Leu Ser Val His Glu Asp Lys 
145                 150                 155                 160 


Asn Arg Val Pro Phe Val Lys Gly Cys Thr Glu Arg Phe Val Ser Ser 
                165                 170                 175     


Pro Glu Glu Ile Leu Asp Val Ile Asp Glu Gly Lys Ser Asn Arg His 
            180                 185                 190         


Val Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile 
        195                 200                 205             


Phe Leu Ile Asn Ile Lys Gln Glu Asn Met Glu Thr Glu Gln Lys Leu 
    210                 215                 220                 


Ser Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser 
225                 230                 235                 240 


Lys Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn 
                245                 250                 255     


Lys Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly 
            260                 265                 270         


Thr Lys Ser Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu 
        275                 280                 285             


Gln Asp Ser Leu Gly Gly Asn Cys Arg Thr Thr Met Phe Ile Cys Cys 
    290                 295                 300                 


Ser Pro Ser Ser Tyr Asn Asp Ala Glu Thr Lys Ser Thr Leu Met Phe 
305                 310                 315                 320 


Gly Gln Arg Ala Lys Thr Ile Lys Asn Thr Ala Ser Val Asn Leu Glu 
                325                 330                 335     


Leu Thr Ala Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys 
            340                 345                 350         


Thr Lys Ala Gln Lys Glu Thr Ile Ala Lys Leu Glu Ala Glu Leu Ser 
        355                 360                 365             


Arg Trp Arg Asn Gly Glu Asn Val Pro Glu Thr Glu Arg Leu Ala Gly 
    370                 375                 380                 


Glu Glu Ala Ala Leu Gly Ala Glu Leu Cys Glu Glu Thr Pro Val Asn 
385                 390                 395                 400 


Asp Asn Ser Ser Ile Val Val Arg Ile Ala Pro Glu Glu Arg Gln Lys 
                405                 410                 415     


Tyr Glu Glu Glu Ile Arg Arg Leu Tyr Lys Gln Leu Asp Asp Lys Asp 
            420                 425                 430         


Asp Glu Ile Asn Gln Gln Ser Gln Leu Ile Glu Lys Leu Lys Gln Gln 
        435                 440                 445             


Met Leu Asp Gln Glu Glu Leu Leu Val Ser Thr Arg Gly Asp Asn Glu 
    450                 455                 460                 


Lys Val Gln Arg Glu Leu Ser His Leu Gln Ser Glu Asn Asp Ala Ala 
465                 470                 475                 480 


Lys Asp Glu Val Lys Glu Val Leu Gln Ala Leu Glu Glu Leu Ala Val 
                485                 490                 495     


Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Glu Lys Ser Gln Gln Asn 
            500                 505                 510         


Gln Leu Leu Val Asp Glu Leu Ser Gln Lys Val Ala Thr Met Leu Ser 
        515                 520                 525             


Leu Glu Ser Glu Leu Gln Arg Leu Gln Glu Val Ser Gly His Gln Arg 
    530                 535                 540                 


Lys Arg Ile Ala Glu Val Leu Asn Gly Leu Met Lys Asp Leu Ser Glu 
545                 550                 555                 560 


Phe Ser Val Ile Val Gly Asn Gly Glu Ile Lys Leu Pro Val Glu Ile 
                565                 570                 575     


Ser Gly Ala Ile Glu Glu Glu Phe Thr Val Ala Arg Leu Tyr Ile Ser 
            580                 585                 590         


Lys Ile Lys Ser Glu Val Lys Ser Val Val Lys Arg Cys Arg Gln Leu 
        595                 600                 605             


Glu Asn Leu Gln Val Glu Cys His Arg Lys Met Glu Val Thr Gly Arg 
    610                 615                 620                 


Glu Leu Ser Ser Cys Gln Leu Leu Ile Ser Gln His Glu Ala Lys Ile 
625                 630                 635                 640 


Arg Ser Leu Thr Glu Tyr Met Gln Ser Val Glu Leu Lys Lys Arg His 
                645                 650                 655     


Leu Glu Glu Ser Tyr Asp Ser Leu Ser Asp Glu Leu Ala Lys Leu Gln 
            660                 665                 670         


Ala Gln Glu Thr Val His Glu Val Ala Leu Lys Asp Lys Glu Pro Asp 
        675                 680                 685             


Thr Gln Asp Ala Asp Glu Val Lys Lys Ala Leu Glu Leu Gln Met Glu 
    690                 695                 700                 


Ser His Arg Glu Ala His His Arg Gln Leu Ala Arg Leu Arg Asp Glu 
705                 710                 715                 720 


Ile Asn Glu Lys Gln Lys Thr Ile Asp Glu Leu Lys Asp Leu Asn Gln 
                725                 730                 735     


Lys Leu Gln Leu Glu Leu Glu Lys Leu Gln Ala Asp Tyr Glu Lys Leu 
            740                 745                 750         


Lys Ser Glu Glu His Glu Lys Ser Thr Lys Leu Gln Glu Leu Thr Phe 
        755                 760                 765             


Leu Tyr Glu Arg His Glu Gln Ser Lys Gln Asp Leu Lys Gly Leu Glu 
    770                 775                 780                 


Glu Thr Val Ala Arg Glu Leu Gln Thr Leu His Asn Leu Arg Lys Leu 
785                 790                 795                 800 


Phe Val Gln Asp Val Thr Thr Arg Val Lys Lys Ser Ala Glu Met Glu 
                805                 810                 815     


Pro Glu Asp Ser Gly Gly Ile His Ser Gln Lys Gln Lys Ile Ser Phe 
            820                 825                 830         


Leu Glu Asn Asn Leu Glu Gln Leu Thr Lys Val His Lys Gln Leu Val 
        835                 840                 845             


Arg Asp Asn Ala Asp Leu Arg Cys Glu Leu Pro Lys Leu Glu Lys Arg 
    850                 855                 860                 


Leu Arg Ala Thr Ala Glu Arg Val Lys Ala Leu Glu Gly Ala Leu Lys 
865                 870                 875                 880 


Glu Ala Lys Glu Gly Ala Met Lys Asp Lys Arg Arg Tyr Gln Gln Glu 
                885                 890                 895     


Val Asp Arg Ile Lys Glu Ala Val Arg Tyr Lys Ser Ser Gly Lys Arg 
            900                 905                 910         


Gly His Ser Ala Gln Ile Ala Lys Pro Val Arg Pro Gly His Tyr Pro 
        915                 920                 925             


Ala Ser Ser Pro Thr Asn Pro Tyr Gly Thr Arg Ser Pro Glu Cys Ile 
    930                 935                 940                 


Ser Tyr Thr Asn Ser Leu Phe Gln Asn Tyr Gln Asn Leu Tyr Leu Gln 
945                 950                 955                 960 


Ala Thr Pro Ser Ser Thr Ser Asp Met Tyr Phe Ala Asn Ser Cys Thr 
                965                 970                 975     


Ser Ser Gly Ala Thr Ser Ser Gly Gly Pro Leu Ala Ser Tyr Gln Lys 
            980                 985                 990         


Ala Asn Met Asp Asn Gly Asn Ala  Thr Asp Ile Asn Asp  Asn Arg Ser 
        995                 1000                 1005             


Asp Leu  Pro Cys Gly Tyr Glu  Ala Glu Asp Gln Ala  Lys Leu Phe 
    1010                 1015                 1020             


Pro Leu  His Gln Glu Thr Ala  Ala Ser 
    1025                 1030         


<210>  5896
<211>  963
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF5B__Homo_sapiens__NP_004512

<400>  5896

Met Ala Asp Leu Ala Glu Cys Asn Ile Lys Val Met Cys Arg Phe Arg 
1               5                   10                  15      


Pro Leu Asn Glu Ser Glu Val Asn Arg Gly Asp Lys Tyr Ile Ala Lys 
            20                  25                  30          


Phe Gln Gly Glu Asp Thr Val Val Ile Ala Ser Lys Pro Tyr Ala Phe 
        35                  40                  45              


Asp Arg Val Phe Gln Ser Ser Thr Ser Gln Glu Gln Val Tyr Asn Asp 
    50                  55                  60                  


Cys Ala Lys Lys Ile Val Lys Asp Val Leu Glu Gly Tyr Asn Gly Thr 
65                  70                  75                  80  


Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met Glu 
                85                  90                  95      


Gly Lys Leu His Asp Pro Glu Gly Met Gly Ile Ile Pro Arg Ile Val 
            100                 105                 110         


Gln Asp Ile Phe Asn Tyr Ile Tyr Ser Met Asp Glu Asn Leu Glu Phe 
        115                 120                 125             


His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg Asp 
    130                 135                 140                 


Leu Leu Asp Val Ser Lys Thr Asn Leu Ser Val His Glu Asp Lys Asn 
145                 150                 155                 160 


Arg Val Pro Tyr Val Lys Gly Cys Thr Glu Arg Phe Val Cys Ser Pro 
                165                 170                 175     


Asp Glu Val Met Asp Thr Ile Asp Glu Gly Lys Ser Asn Arg His Val 
            180                 185                 190         


Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile Phe 
        195                 200                 205             


Leu Ile Asn Val Lys Gln Glu Asn Thr Gln Thr Glu Gln Lys Leu Ser 
    210                 215                 220                 


Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser Lys 
225                 230                 235                 240 


Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn Lys 
                245                 250                 255     


Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly Ser 
            260                 265                 270         


Thr Tyr Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu Gln Asp 
        275                 280                 285             


Ser Leu Gly Gly Asn Cys Arg Thr Thr Ile Val Ile Cys Cys Ser Pro 
    290                 295                 300                 


Ser Ser Tyr Asn Glu Ser Glu Thr Lys Ser Thr Leu Leu Phe Gly Gln 
305                 310                 315                 320 


Arg Ala Lys Thr Ile Lys Asn Thr Val Cys Val Asn Val Glu Leu Thr 
                325                 330                 335     


Ala Glu Gln Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys Asn Lys 
            340                 345                 350         


Ile Leu Arg Asn Thr Ile Gln Trp Leu Glu Asn Glu Leu Asn Arg Trp 
        355                 360                 365             


Arg Asn Gly Glu Thr Val Pro Ile Asp Glu Gln Phe Asp Lys Glu Lys 
    370                 375                 380                 


Ala Asn Leu Glu Ala Phe Thr Val Asp Lys Asp Ile Thr Leu Thr Asn 
385                 390                 395                 400 


Asp Lys Pro Ala Thr Ala Ile Gly Val Ile Gly Asn Phe Thr Asp Ala 
                405                 410                 415     


Glu Arg Arg Lys Cys Glu Glu Glu Ile Ala Lys Leu Tyr Lys Gln Leu 
            420                 425                 430         


Asp Asp Lys Asp Glu Glu Ile Asn Gln Gln Ser Gln Leu Val Glu Lys 
        435                 440                 445             


Leu Lys Thr Gln Met Leu Asp Gln Glu Glu Leu Leu Ala Ser Thr Arg 
    450                 455                 460                 


Arg Asp Gln Asp Asn Met Gln Ala Glu Leu Asn Arg Leu Gln Ala Glu 
465                 470                 475                 480 


Asn Asp Ala Ser Lys Glu Glu Val Lys Glu Val Leu Gln Ala Leu Glu 
                485                 490                 495     


Glu Leu Ala Val Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Asp Lys 
            500                 505                 510         


Thr Lys Glu Tyr Glu Leu Leu Ser Asp Glu Leu Asn Gln Lys Ser Ala 
        515                 520                 525             


Thr Leu Ala Ser Ile Asp Ala Glu Leu Gln Lys Leu Lys Glu Met Thr 
    530                 535                 540                 


Asn His Gln Lys Lys Arg Ala Ala Glu Met Met Ala Ser Leu Leu Lys 
545                 550                 555                 560 


Asp Leu Ala Glu Ile Gly Ile Ala Val Gly Asn Asn Asp Val Lys Gln 
                565                 570                 575     


Pro Glu Gly Thr Gly Met Ile Asp Glu Glu Phe Thr Val Ala Arg Leu 
            580                 585                 590         


Tyr Ile Ser Lys Met Lys Ser Glu Val Lys Thr Met Val Lys Arg Cys 
        595                 600                 605             


Lys Gln Leu Glu Ser Thr Gln Thr Glu Ser Asn Lys Lys Met Glu Glu 
    610                 615                 620                 


Asn Glu Lys Glu Leu Ala Ala Cys Gln Leu Arg Ile Ser Gln His Glu 
625                 630                 635                 640 


Ala Lys Ile Lys Ser Leu Thr Glu Tyr Leu Gln Asn Val Glu Gln Lys 
                645                 650                 655     


Lys Arg Gln Leu Glu Glu Ser Val Asp Ala Leu Ser Glu Glu Leu Val 
            660                 665                 670         


Gln Leu Arg Ala Gln Glu Lys Val His Glu Met Glu Lys Glu His Leu 
        675                 680                 685             


Asn Lys Val Gln Thr Ala Asn Glu Val Lys Gln Ala Val Glu Gln Gln 
    690                 695                 700                 


Ile Gln Ser His Arg Glu Thr His Gln Lys Gln Ile Ser Ser Leu Arg 
705                 710                 715                 720 


Asp Glu Val Glu Ala Lys Ala Lys Leu Ile Thr Asp Leu Gln Asp Gln 
                725                 730                 735     


Asn Gln Lys Met Met Leu Glu Gln Glu Arg Leu Arg Val Glu His Glu 
            740                 745                 750         


Lys Leu Lys Ala Thr Asp Gln Glu Lys Ser Arg Lys Leu His Glu Leu 
        755                 760                 765             


Thr Val Met Gln Asp Arg Arg Glu Gln Ala Arg Gln Asp Leu Lys Gly 
    770                 775                 780                 


Leu Glu Glu Thr Val Ala Lys Glu Leu Gln Thr Leu His Asn Leu Arg 
785                 790                 795                 800 


Lys Leu Phe Val Gln Asp Leu Ala Thr Arg Val Lys Lys Ser Ala Glu 
                805                 810                 815     


Ile Asp Ser Asp Asp Thr Gly Gly Ser Ala Ala Gln Lys Gln Lys Ile 
            820                 825                 830         


Ser Phe Leu Glu Asn Asn Leu Glu Gln Leu Thr Lys Val His Lys Gln 
        835                 840                 845             


Leu Val Arg Asp Asn Ala Asp Leu Arg Cys Glu Leu Pro Lys Leu Glu 
    850                 855                 860                 


Lys Arg Leu Arg Ala Thr Ala Glu Arg Val Lys Ala Leu Glu Ser Ala 
865                 870                 875                 880 


Leu Lys Glu Ala Lys Glu Asn Ala Ser Arg Asp Arg Lys Arg Tyr Gln 
                885                 890                 895     


Gln Glu Val Asp Arg Ile Lys Glu Ala Val Arg Ser Lys Asn Met Ala 
            900                 905                 910         


Arg Arg Gly His Ser Ala Gln Ile Ala Lys Pro Ile Arg Pro Gly Gln 
        915                 920                 925             


His Pro Ala Ala Ser Pro Thr His Pro Ser Ala Ile Arg Gly Gly Gly 
    930                 935                 940                 


Ala Phe Val Gln Asn Ser Gln Pro Val Ala Val Arg Gly Gly Gly Gly 
945                 950                 955                 960 


Lys Gln Val 
            


<210>  5897
<211>  957
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF5C__Homo_sapiens__NP_004513

<400>  5897

Met Ala Asp Pro Ala Glu Cys Ser Ile Lys Val Met Cys Arg Phe Arg 
1               5                   10                  15      


Pro Leu Asn Glu Ala Glu Ile Leu Arg Gly Asp Lys Phe Ile Pro Lys 
            20                  25                  30          


Phe Lys Gly Asp Glu Thr Val Val Ile Gly Gln Gly Lys Pro Tyr Val 
        35                  40                  45              


Phe Asp Arg Val Leu Pro Pro Asn Thr Thr Gln Glu Gln Val Tyr Asn 
    50                  55                  60                  


Ala Cys Ala Lys Gln Ile Val Lys Asp Val Leu Glu Gly Tyr Asn Gly 
65                  70                  75                  80  


Thr Ile Phe Ala Tyr Gly Gln Thr Ser Ser Gly Lys Thr His Thr Met 
                85                  90                  95      


Glu Gly Lys Leu His Asp Pro Gln Leu Met Gly Ile Ile Pro Arg Ile 
            100                 105                 110         


Ala His Asp Ile Phe Asp His Ile Tyr Ser Met Asp Glu Asn Leu Glu 
        115                 120                 125             


Phe His Ile Lys Val Ser Tyr Phe Glu Ile Tyr Leu Asp Lys Ile Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Ser Lys Thr Asn Leu Ala Val His Glu Asp Lys 
145                 150                 155                 160 


Asn Arg Val Pro Tyr Val Lys Gly Cys Thr Glu Arg Phe Val Ser Ser 
                165                 170                 175     


Pro Glu Glu Val Met Asp Val Ile Asp Glu Gly Lys Ala Asn Arg His 
            180                 185                 190         


Val Ala Val Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ser Ile 
        195                 200                 205             


Phe Leu Ile Asn Ile Lys Gln Glu Asn Val Glu Thr Glu Lys Lys Leu 
    210                 215                 220                 


Ser Gly Lys Leu Tyr Leu Val Asp Leu Ala Gly Ser Glu Lys Val Ser 
225                 230                 235                 240 


Lys Thr Gly Ala Glu Gly Ala Val Leu Asp Glu Ala Lys Asn Ile Asn 
                245                 250                 255     


Lys Ser Leu Ser Ala Leu Gly Asn Val Ile Ser Ala Leu Ala Glu Gly 
            260                 265                 270         


Thr Lys Thr His Val Pro Tyr Arg Asp Ser Lys Met Thr Arg Ile Leu 
        275                 280                 285             


Gln Asp Ser Leu Gly Gly Asn Cys Arg Thr Thr Ile Val Ile Cys Cys 
    290                 295                 300                 


Ser Pro Ser Val Phe Asn Glu Ala Glu Thr Lys Ser Thr Leu Met Phe 
305                 310                 315                 320 


Gly Gln Arg Ala Lys Thr Ile Lys Asn Thr Val Ser Val Asn Leu Glu 
                325                 330                 335     


Leu Thr Ala Glu Glu Trp Lys Lys Lys Tyr Glu Lys Glu Lys Glu Lys 
            340                 345                 350         


Asn Lys Thr Leu Lys Asn Val Ile Gln His Leu Glu Met Glu Leu Asn 
        355                 360                 365             


Arg Trp Arg Asn Gly Glu Ala Val Pro Glu Asp Glu Gln Ile Ser Ala 
    370                 375                 380                 


Lys Asp Gln Lys Asn Leu Glu Pro Cys Asp Asn Thr Pro Ile Ile Asp 
385                 390                 395                 400 


Asn Ile Ala Pro Val Val Ala Gly Ile Ser Thr Glu Glu Lys Glu Lys 
                405                 410                 415     


Tyr Asp Glu Glu Ile Ser Ser Leu Tyr Arg Gln Leu Asp Asp Lys Asp 
            420                 425                 430         


Asp Glu Ile Asn Gln Gln Ser Gln Leu Ala Glu Lys Leu Lys Gln Gln 
        435                 440                 445             


Met Leu Asp Gln Asp Glu Leu Leu Ala Ser Thr Arg Arg Asp Tyr Glu 
    450                 455                 460                 


Lys Ile Gln Glu Glu Leu Thr Arg Leu Gln Ile Glu Asn Glu Ala Ala 
465                 470                 475                 480 


Lys Asp Glu Val Lys Glu Val Leu Gln Ala Leu Glu Glu Leu Ala Val 
                485                 490                 495     


Asn Tyr Asp Gln Lys Ser Gln Glu Val Glu Asp Lys Thr Arg Ala Asn 
            500                 505                 510         


Glu Gln Leu Thr Asp Glu Leu Ala Gln Lys Thr Thr Thr Leu Thr Thr 
        515                 520                 525             


Thr Gln Arg Glu Leu Ser Gln Leu Gln Glu Leu Ser Asn His Gln Lys 
    530                 535                 540                 


Lys Arg Ala Thr Glu Ile Leu Asn Leu Leu Leu Lys Asp Leu Gly Glu 
545                 550                 555                 560 


Ile Gly Gly Ile Ile Gly Thr Asn Asp Val Lys Thr Leu Ala Asp Val 
                565                 570                 575     


Asn Gly Val Ile Glu Glu Glu Phe Thr Met Ala Arg Leu Tyr Ile Ser 
            580                 585                 590         


Lys Met Lys Ser Glu Val Lys Ser Leu Val Asn Arg Ser Lys Gln Leu 
        595                 600                 605             


Glu Ser Ala Gln Met Asp Ser Asn Arg Lys Met Asn Ala Ser Glu Arg 
    610                 615                 620                 


Glu Leu Ala Ala Cys Gln Leu Leu Ile Ser Gln His Glu Ala Lys Ile 
625                 630                 635                 640 


Lys Ser Leu Thr Asp Tyr Met Gln Asn Met Glu Gln Lys Arg Arg Gln 
                645                 650                 655     


Leu Glu Glu Ser Gln Asp Ser Leu Ser Glu Glu Leu Ala Lys Leu Arg 
            660                 665                 670         


Ala Gln Glu Lys Met His Glu Val Ser Phe Gln Asp Lys Glu Lys Glu 
        675                 680                 685             


His Leu Thr Arg Leu Gln Asp Ala Glu Glu Met Lys Lys Ala Leu Glu 
    690                 695                 700                 


Gln Gln Met Glu Ser His Arg Glu Ala His Gln Lys Gln Leu Ser Arg 
705                 710                 715                 720 


Leu Arg Asp Glu Ile Glu Glu Lys Gln Lys Ile Ile Asp Glu Ile Arg 
                725                 730                 735     


Asp Leu Asn Gln Lys Leu Gln Leu Glu Gln Glu Lys Leu Ser Ser Asp 
            740                 745                 750         


Tyr Asn Lys Leu Lys Ile Glu Asp Gln Glu Arg Glu Met Lys Leu Glu 
        755                 760                 765             


Lys Leu Leu Leu Leu Asn Asp Lys Arg Glu Gln Ala Arg Glu Asp Leu 
    770                 775                 780                 


Lys Gly Leu Glu Glu Thr Val Ser Arg Glu Leu Gln Thr Leu His Asn 
785                 790                 795                 800 


Leu Arg Lys Leu Phe Val Gln Asp Leu Thr Thr Arg Val Lys Lys Ser 
                805                 810                 815     


Val Glu Leu Asp Asn Asp Asp Gly Gly Gly Ser Ala Ala Gln Lys Gln 
            820                 825                 830         


Lys Ile Ser Phe Leu Glu Asn Asn Leu Glu Gln Leu Thr Lys Val His 
        835                 840                 845             


Lys Gln Leu Val Arg Asp Asn Ala Asp Leu Arg Cys Glu Leu Pro Lys 
    850                 855                 860                 


Leu Glu Lys Arg Leu Arg Ala Thr Ala Glu Arg Val Lys Ala Leu Glu 
865                 870                 875                 880 


Ser Ala Leu Lys Glu Ala Lys Glu Asn Ala Met Arg Asp Arg Lys Arg 
                885                 890                 895     


Tyr Gln Gln Glu Val Asp Arg Ile Lys Glu Ala Val Arg Ala Lys Asn 
            900                 905                 910         


Met Ala Arg Arg Ala His Ser Ala Gln Ile Ala Lys Pro Ile Arg Pro 
        915                 920                 925             


Gly His Tyr Pro Ala Ser Ser Pro Thr Ala Val His Ala Ile Arg Gly 
    930                 935                 940                 


Gly Gly Gly Ser Ser Ser Asn Ser Thr His Tyr Gln Lys 
945                 950                 955         


<210>  5898
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF6__Homo_sapiens__NP_001275949

<400>  5898

Met Val Lys Gln Thr Ile Gln Ile Phe Ala Arg Val Lys Pro Pro Val 
1               5                   10                  15      


Arg Lys His Gln Gln Gly Ile Tyr Ser Ile Asp Glu Asp Glu Lys Leu 
            20                  25                  30          


Ile Pro Ser Leu Glu Ile Ile Leu Pro Arg Asp Leu Ala Asp Gly Phe 
        35                  40                  45              


Val Asn Asn Lys Arg Glu Ser Tyr Lys Phe Lys Phe Gln Arg Ile Phe 
    50                  55                  60                  


Asp Gln Asp Ala Asn Gln Glu Thr Val Phe Glu Asn Ile Ala Lys Pro 
65                  70                  75                  80  


Val Ala Gly Ser Val Leu Ala Gly Tyr Asn Gly Thr Ile Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Ser Gly Lys Thr Phe Thr Ile Thr Gly Gly Ala Glu 
            100                 105                 110         


Arg Tyr Ser Asp Arg Gly Ile Ile Pro Arg Thr Leu Ser Tyr Ile Phe 
        115                 120                 125             


Glu Gln Leu Gln Lys Asp Ser Ser Lys Ile Tyr Thr Thr His Ile Ser 
    130                 135                 140                 


Tyr Leu Glu Ile Tyr Asn Glu Cys Gly Tyr Asp Leu Leu Asp Pro Arg 
145                 150                 155                 160 


His Glu Ala Ser Ser Leu Glu Asp Leu Pro Lys Val Thr Ile Leu Glu 
                165                 170                 175     


Asp Pro Asp Gln Asn Ile His Leu Lys Asn Leu Thr Leu His Gln Ala 
            180                 185                 190         


Thr Thr Glu Glu Glu Ala Leu Asn Leu Leu Phe Leu Gly Asp Thr Asn 
        195                 200                 205             


Arg Met Ile Ala Glu Thr Pro Met Asn Gln Ala Ser Thr Arg Ser His 
    210                 215                 220                 


Cys Ile Phe Thr Ile His Leu Ser Ser Lys Glu Pro Gly Ser Ala Thr 
225                 230                 235                 240 


Val Arg His Ala Lys Leu His Leu Val Asp Leu Ala Gly Ser Glu Arg 
                245                 250                 255     


Val Ala Lys Thr Gly Val Gly Gly His Leu Leu Thr Glu Ala Lys Tyr 
            260                 265                 270         


Ile Asn Leu Ser Leu His Tyr Leu Glu Gln Val Ile Ile Ala Leu Ser 
        275                 280                 285             


Glu Lys His Arg Ser His Ile Pro Tyr Arg Asn Ser Met Met Thr Ser 
    290                 295                 300                 


Val Leu Arg Asp Ser Leu Gly Gly Asn Cys Met Thr Thr Met Ile Ala 
305                 310                 315                 320 


Thr Leu Ser Leu Glu Lys Arg Asn Leu Asp Glu Ser Ile Ser Thr Cys 
                325                 330                 335     


Arg Phe Ala Gln Arg Val Ala Leu Ile Lys Asn Glu Ala Val Leu Asn 
            340                 345                 350         


Glu Glu Ile Asn Pro Arg Leu Val Ile Lys Arg Leu Gln Lys Glu Ile 
        355                 360                 365             


Gln Glu Leu Lys Asp Glu Leu Ala Met Val Thr Gly Glu Gln Arg Thr 
    370                 375                 380                 


Glu Ala Leu Thr Glu Ala Glu Leu Leu Gln Leu Glu Lys Leu Ile Thr 
385                 390                 395                 400 


Ser Phe Leu Glu Asp Gln Asp Ser Asp Ser Arg Leu Glu Val Gly Ala 
                405                 410                 415     


Asp Met Arg Lys Val His His Cys Phe His His Leu Lys Lys Leu Leu 
            420                 425                 430         


Asn Asp Lys Lys Ile Leu Glu Asn Asn Thr Val Ser Ser Glu Ser Lys 
        435                 440                 445             


Asp Gln Asp Cys Gln Glu Pro Leu Lys Glu Glu Glu Tyr Arg Lys Leu 
    450                 455                 460                 


Arg Asp Ile Leu Lys Gln Arg Asp Asn Glu Ile Asn Ile Leu Val Asn 
465                 470                 475                 480 


Met Leu Lys Lys Glu Lys Lys Lys Ala Gln Glu Ala Leu His Leu Ala 
                485                 490                 495     


Gly Met Asp Arg Arg Glu Phe Arg Gln Ser Gln Ser Pro Pro Phe Arg 
            500                 505                 510         


Leu Gly Asn Pro Glu Glu Gly Gln Arg Met Arg Leu Ser Ser Ala Pro 
        515                 520                 525             


Ser Gln Ala Gln Asp Phe Ser Ile Leu Gly Lys Arg Ser Ser Leu Leu 
    530                 535                 540                 


His Lys Lys Ile Gly Met Arg Glu Glu Met Ser Leu Gly Cys Gln Glu 
545                 550                 555                 560 


Ala Phe Glu Ile Phe Lys Arg Asp His Ala Asp Ser Val Thr Ile Asp 
                565                 570                 575     


Asp Asn Lys Gln Ile Leu Lys Gln Arg Phe Ser Glu Ala Lys Ala Leu 
            580                 585                 590         


Gly Glu Ser Ile Asn Glu Ala Arg Ser Lys Ile Gly Ile Ser Glu Asn 
        595                 600                 605             


Met Ala Val Pro Leu Met Pro Asp Gln Gln Glu Glu Lys Leu Arg Ser 
    610                 615                 620                 


Gln Leu Glu Glu Glu Lys Arg Arg Tyr Lys Thr Met Phe Thr Arg Leu 
625                 630                 635                 640 


Lys Ala Leu Lys Val Glu Ile Glu His Leu Gln Leu Leu Met Asp Lys 
                645                 650                 655     


Ala Lys Val Lys Leu Gln Lys Glu Phe Glu Val Trp Trp Ala Glu Glu 
            660                 665                 670         


Ala Thr Asn Leu Gln Val Asn Ser Pro Ala Val Asn Ser Leu Asp His 
        675                 680                 685             


Thr Lys Pro Phe Leu Gln Thr Ser Asp Ser Gln His Glu Trp Ser Gln 
    690                 695                 700                 


Leu Leu Ser Asn Lys Ser Ser Gly Gly Trp Glu Val Gln Asp Gln Gly 
705                 710                 715                 720 


Thr Gly Arg Phe Asp Val Cys Asp Val Asn Ala Arg Lys Ile Leu Pro 
                725                 730                 735     


Ser Pro Cys Pro Ser Pro His Ser Gln Lys Gln Ser Ser Thr Ser Thr 
            740                 745                 750         


Pro Leu Glu Asp Ser Ile Pro Lys Arg Pro Val Ser Ser Ile Pro Leu 
        755                 760                 765             


Thr Gly Asp Ser Gln Thr Asp Ser Asp Ile Ile Ala Phe Ile Lys Ala 
    770                 775                 780                 


Arg Gln Ser Ile Leu Gln Lys Gln Cys Leu Gly Ser Asn 
785                 790                 795         


<210>  5899
<211>  1343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF7__Homo_sapiens__XP_005254959

<400>  5899

Met Gly Leu Glu Ala Gln Arg Leu Pro Gly Ala Glu Glu Ala Pro Val 
1               5                   10                  15      


Arg Val Ala Leu Arg Val Arg Pro Leu Leu Pro Lys Glu Leu Leu His 
            20                  25                  30          


Gly His Gln Ser Cys Leu Gln Val Glu Pro Gly Leu Gly Arg Val Thr 
        35                  40                  45              


Leu Gly Arg Asp Arg His Phe Gly Phe His Val Val Leu Ala Glu Asp 
    50                  55                  60                  


Ala Gly Gln Glu Ala Val Tyr Gln Ala Cys Val Gln Pro Leu Leu Glu 
65                  70                  75                  80  


Ala Phe Phe Glu Gly Phe Asn Ala Thr Val Phe Ala Tyr Gly Gln Thr 
                85                  90                  95      


Gly Ser Gly Lys Thr Tyr Thr Met Gly Glu Ala Ser Val Ala Ser Leu 
            100                 105                 110         


Leu Glu Asp Glu Gln Gly Ile Val Pro Arg Ala Met Ala Glu Ala Phe 
        115                 120                 125             


Lys Leu Ile Asp Glu Asn Asp Leu Leu Asp Cys Leu Val His Val Ser 
    130                 135                 140                 


Tyr Leu Glu Val Tyr Lys Glu Glu Phe Arg Asp Leu Leu Glu Val Gly 
145                 150                 155                 160 


Thr Ala Ser Arg Asp Ile Gln Leu Arg Glu Asp Glu Arg Gly Asn Val 
                165                 170                 175     


Val Leu Cys Gly Val Lys Glu Val Asp Val Glu Gly Leu Asp Glu Val 
            180                 185                 190         


Leu Ser Leu Leu Glu Met Gly Asn Ala Ala Arg His Thr Gly Ala Thr 
        195                 200                 205             


His Leu Asn His Leu Ser Ser Arg Ser His Thr Val Phe Thr Val Thr 
    210                 215                 220                 


Leu Glu Gln Arg Gly Arg Ala Pro Ser Arg Leu Pro Arg Pro Ala Pro 
225                 230                 235                 240 


Gly Gln Leu Leu Val Ser Lys Phe His Phe Val Asp Leu Ala Gly Ser 
                245                 250                 255     


Glu Arg Val Leu Lys Thr Gly Ser Thr Gly Glu Arg Leu Lys Glu Ser 
            260                 265                 270         


Ile Gln Ile Asn Ser Ser Leu Leu Ala Leu Gly Asn Val Ile Ser Ala 
        275                 280                 285             


Leu Gly Asp Pro Gln Arg Arg Gly Ser His Ile Pro Tyr Arg Asp Ser 
    290                 295                 300                 


Lys Ile Thr Arg Ile Leu Lys Asp Ser Leu Gly Gly Asn Ala Lys Thr 
305                 310                 315                 320 


Val Met Ile Ala Cys Val Ser Pro Ser Ser Ser Asp Phe Asp Glu Thr 
                325                 330                 335     


Leu Asn Thr Leu Asn Tyr Ala Ser Arg Ala Gln Asn Ile Arg Asn Arg 
            340                 345                 350         


Ala Thr Val Asn Trp Arg Pro Glu Ala Glu Arg Pro Pro Glu Glu Thr 
        355                 360                 365             


Ala Ser Gly Ala Arg Gly Pro Pro Arg His Arg Ser Glu Thr Arg Ile 
    370                 375                 380                 


Ile His Arg Gly Arg Arg Ala Pro Gly Pro Ala Thr Ala Ser Ala Ala 
385                 390                 395                 400 


Ala Ala Met Arg Leu Gly Ala Glu Cys Ala Arg Tyr Arg Ala Cys Thr 
                405                 410                 415     


Asp Ala Ala Tyr Ser Leu Leu Arg Glu Leu Gln Ala Glu Pro Gly Leu 
            420                 425                 430         


Pro Gly Ala Ala Ala Arg Lys Val Arg Asp Trp Leu Cys Ala Val Glu 
        435                 440                 445             


Gly Glu Arg Ser Ala Leu Ser Ser Ala Ser Gly Pro Asp Ser Gly Ile 
    450                 455                 460                 


Glu Ser Ala Ser Val Glu Asp Gln Ala Ala Gln Gly Ala Gly Gly Arg 
465                 470                 475                 480 


Lys Glu Asp Glu Gly Ala Gln Gln Leu Leu Thr Leu Gln Asn Gln Val 
                485                 490                 495     


Ala Arg Leu Glu Glu Glu Asn Arg Asp Phe Leu Ala Ala Leu Glu Asp 
            500                 505                 510         


Ala Met Glu Gln Tyr Lys Leu Gln Ser Asp Arg Leu Arg Glu Gln Gln 
        515                 520                 525             


Glu Glu Met Val Glu Leu Arg Leu Arg Leu Glu Leu Val Arg Pro Gly 
    530                 535                 540                 


Trp Gly Gly Pro Arg Leu Leu Asn Gly Leu Pro Pro Gly Ser Phe Val 
545                 550                 555                 560 


Pro Arg Pro His Thr Ala Pro Leu Gly Gly Ala His Ala His Val Leu 
                565                 570                 575     


Gly Met Val Pro Pro Ala Cys Leu Pro Gly Asp Glu Val Gly Ser Glu 
            580                 585                 590         


Gln Arg Gly Glu Gln Val Thr Asn Gly Arg Glu Ala Gly Ala Glu Leu 
        595                 600                 605             


Leu Thr Glu Val Asn Arg Leu Gly Ser Gly Ser Ser Ala Ala Ser Glu 
    610                 615                 620                 


Glu Glu Glu Glu Glu Glu Glu Pro Pro Arg Arg Thr Leu His Leu Arg 
625                 630                 635                 640 


Arg Asn Arg Ile Ser Asn Cys Ser Gln Arg Ala Gly Ala Arg Pro Gly 
                645                 650                 655     


Ser Leu Pro Glu Arg Lys Gly Pro Glu Leu Cys Leu Glu Glu Leu Asp 
            660                 665                 670         


Ala Ala Ile Pro Gly Ser Arg Ala Val Gly Gly Ser Lys Ala Arg Val 
        675                 680                 685             


Gln Ala Arg Gln Val Pro Pro Ala Thr Ala Ser Glu Trp Arg Leu Ala 
    690                 695                 700                 


Gln Ala Gln Gln Lys Ile Arg Glu Leu Ala Ile Asn Ile Arg Met Lys 
705                 710                 715                 720 


Glu Glu Leu Ile Gly Glu Leu Val Arg Thr Gly Lys Ala Ala Gln Ala 
                725                 730                 735     


Leu Asn Arg Gln His Ser Gln Arg Ile Arg Glu Leu Glu Gln Glu Ala 
            740                 745                 750         


Glu Gln Val Arg Ala Glu Leu Ser Glu Gly Gln Arg Gln Leu Arg Glu 
        755                 760                 765             


Leu Glu Gly Lys Glu Leu Gln Asp Ala Gly Glu Arg Ser Arg Leu Gln 
    770                 775                 780                 


Glu Phe Arg Arg Arg Val Ala Ala Ala Gln Ser Gln Val Gln Val Leu 
785                 790                 795                 800 


Lys Glu Lys Lys Gln Ala Thr Glu Arg Leu Val Ser Leu Ser Ala Gln 
                805                 810                 815     


Ser Glu Lys Arg Leu Gln Glu Leu Glu Arg Asn Val Gln Leu Met Arg 
            820                 825                 830         


Gln Gln Gln Gly Gln Leu Gln Arg Arg Leu Arg Glu Glu Thr Glu Gln 
        835                 840                 845             


Lys Arg Arg Leu Glu Ala Glu Met Ser Lys Arg Gln His Arg Val Lys 
    850                 855                 860                 


Glu Leu Glu Leu Lys His Glu Gln Gln Gln Lys Ile Leu Lys Ile Lys 
865                 870                 875                 880 


Thr Glu Glu Ile Ala Ala Phe Gln Arg Lys Arg Arg Ser Gly Ser Asn 
                885                 890                 895     


Gly Ser Val Val Ser Leu Glu Gln Gln Gln Lys Ile Glu Glu Gln Lys 
            900                 905                 910         


Lys Trp Leu Asp Gln Glu Met Glu Lys Val Leu Gln Gln Arg Arg Ala 
        915                 920                 925             


Leu Glu Glu Leu Gly Glu Glu Leu His Lys Arg Glu Ala Ile Leu Ala 
    930                 935                 940                 


Lys Lys Glu Ala Leu Met Gln Glu Lys Thr Gly Leu Glu Ser Lys Arg 
945                 950                 955                 960 


Leu Arg Ser Ser Gln Ala Leu Asn Glu Asp Ile Val Arg Val Ser Ser 
                965                 970                 975     


Arg Leu Glu His Leu Glu Lys Glu Leu Ser Glu Lys Ser Gly Gln Leu 
            980                 985                 990         


Arg Gln Gly Ser Ala Gln Ser Gln  Gln Gln Ile Arg Gly  Glu Ile Asp 
        995                 1000                 1005             


Ser Leu  Arg Gln Glu Lys Asp  Ser Leu Leu Lys Gln  Arg Leu Glu 
    1010                 1015                 1020             


Ile Asp  Gly Lys Leu Arg Gln  Gly Ser Leu Leu Ser  Pro Glu Glu 
    1025                 1030                 1035             


Glu Arg  Thr Leu Phe Gln Leu  Asp Glu Ala Ile Glu  Ala Leu Asp 
    1040                 1045                 1050             


Ala Ala  Ile Glu Tyr Lys Asn  Glu Ala Ile Thr Cys  Arg Gln Arg 
    1055                 1060                 1065             


Val Leu  Arg Ala Ser Ala Ser  Leu Leu Ser Gln Cys  Glu Met Asn 
    1070                 1075                 1080             


Leu Met  Ala Lys Leu Ser Tyr  Leu Ser Ser Ser Glu  Thr Arg Ala 
    1085                 1090                 1095             


Leu Leu  Cys Lys Tyr Phe Asp  Lys Val Val Thr Leu  Arg Glu Glu 
    1100                 1105                 1110             


Gln His  Gln Gln Gln Ile Ala  Phe Ser Glu Leu Glu  Met Gln Leu 
    1115                 1120                 1125             


Glu Glu  Gln Gln Arg Leu Val  Tyr Trp Leu Glu Val  Ala Leu Glu 
    1130                 1135                 1140             


Arg Gln  Arg Leu Glu Met Asp  Arg Gln Leu Thr Leu  Gln Gln Lys 
    1145                 1150                 1155             


Glu His  Glu Gln Asn Met Gln  Leu Leu Leu Gln Gln  Ser Arg Asp 
    1160                 1165                 1170             


His Leu  Gly Glu Gly Leu Ala  Asp Ser Arg Arg Gln  Tyr Glu Ala 
    1175                 1180                 1185             


Arg Ile  Gln Ala Leu Glu Lys  Glu Leu Gly Arg Tyr  Met Trp Ile 
    1190                 1195                 1200             


Asn Gln  Glu Leu Lys Gln Lys  Leu Gly Gly Val Asn  Ala Val Gly 
    1205                 1210                 1215             


His Ser  Arg Gly Gly Glu Lys  Arg Ser Leu Cys Ser  Glu Gly Arg 
    1220                 1225                 1230             


Gln Ala  Pro Gly Asn Glu Asp  Glu Leu His Leu Ala  Pro Glu Leu 
    1235                 1240                 1245             


Leu Trp  Leu Ser Pro Leu Thr  Glu Gly Ala Pro Arg  Thr Arg Glu 
    1250                 1255                 1260             


Glu Thr  Arg Asp Leu Val His  Ala Pro Leu Pro Leu  Thr Trp Lys 
    1265                 1270                 1275             


Arg Ser  Ser Leu Cys Gly Glu  Glu Gln Gly Ser Pro  Glu Glu Leu 
    1280                 1285                 1290             


Arg Gln  Arg Glu Ala Ala Glu  Pro Leu Val Gly Arg  Val Leu Pro 
    1295                 1300                 1305             


Val Gly  Glu Ala Gly Leu Pro  Trp Asn Phe Gly Pro  Leu Ser Lys 
    1310                 1315                 1320             


Pro Arg  Arg Glu Leu Arg Arg  Ala Ser Pro Gly Met  Ile Asp Val 
    1325                 1330                 1335             


Arg Lys  Asn Pro Leu 
    1340             


<210>  5900
<211>  790
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIF9__Homo_sapiens__NP_001128350

<400>  5900

Met Gly Thr Arg Lys Lys Val His Ala Phe Val Arg Val Lys Pro Thr 
1               5                   10                  15      


Asp Asp Phe Ala His Glu Met Ile Arg Tyr Gly Asp Asp Lys Arg Ser 
            20                  25                  30          


Ile Asp Ile His Leu Lys Lys Asp Ile Arg Arg Gly Val Val Asn Asn 
        35                  40                  45              


Gln Gln Thr Asp Trp Ser Phe Lys Leu Asp Gly Val Leu His Asp Ala 
    50                  55                  60                  


Ser Gln Asp Leu Val Tyr Glu Thr Val Ala Lys Asp Val Val Ser Gln 
65                  70                  75                  80  


Ala Leu Asp Gly Tyr Asn Gly Thr Ile Met Cys Tyr Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Lys Thr Tyr Thr Met Met Gly Ala Thr Glu Asn Tyr Lys His 
            100                 105                 110         


Arg Gly Ile Leu Pro Arg Ala Leu Gln Gln Val Phe Arg Met Ile Glu 
        115                 120                 125             


Glu Arg Pro Thr His Ala Ile Thr Val Arg Val Ser Tyr Leu Glu Ile 
    130                 135                 140                 


Tyr Asn Glu Ser Leu Phe Asp Leu Leu Ser Thr Leu Pro Tyr Val Gly 
145                 150                 155                 160 


Pro Ser Val Thr Pro Met Thr Ile Val Glu Asn Pro Gln Gly Val Phe 
                165                 170                 175     


Ile Lys Gly Leu Ser Val His Leu Thr Ser Gln Glu Glu Asp Ala Phe 
            180                 185                 190         


Ser Leu Leu Phe Glu Gly Glu Thr Asn Arg Ile Ile Ala Ser His Thr 
        195                 200                 205             


Met Asn Lys Asn Ser Ser Arg Ser His Cys Ile Phe Thr Ile Tyr Leu 
    210                 215                 220                 


Glu Ala His Ser Arg Thr Leu Ser Glu Glu Lys Tyr Ile Thr Ser Lys 
225                 230                 235                 240 


Ile Asn Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Gly Lys Ser Gly 
                245                 250                 255     


Ser Glu Gly Gln Val Leu Lys Glu Ala Thr Tyr Ile Asn Lys Ser Leu 
            260                 265                 270         


Ser Phe Leu Glu Gln Ala Ile Ile Ala Leu Gly Asp Gln Lys Arg Asp 
        275                 280                 285             


His Ile Pro Phe Arg Gln Cys Lys Leu Thr His Ala Leu Lys Asp Ser 
    290                 295                 300                 


Leu Gly Gly Asn Cys Asn Met Val Leu Val Thr Asn Ile Tyr Gly Glu 
305                 310                 315                 320 


Ala Ala Gln Leu Glu Glu Thr Leu Ser Ser Leu Arg Phe Ala Ser Arg 
                325                 330                 335     


Met Lys Leu Val Thr Thr Glu Pro Ala Ile Asn Glu Lys Tyr Asp Ala 
            340                 345                 350         


Glu Arg Met Val Lys Asn Leu Glu Lys Glu Leu Ala Leu Leu Lys Gln 
        355                 360                 365             


Glu Leu Ala Ile His Asp Ser Leu Thr Asn Arg Thr Phe Val Thr Tyr 
    370                 375                 380                 


Asp Pro Met Asp Glu Ile Gln Ile Ala Glu Ile Asn Ser Gln Val Arg 
385                 390                 395                 400 


Arg Tyr Leu Glu Gly Thr Leu Asp Glu Ile Asp Ile Ile Ser Leu Arg 
                405                 410                 415     


Gln Ile Lys Glu Val Phe Asn Gln Phe Arg Val Val Leu Ser Gln Gln 
            420                 425                 430         


Glu Gln Glu Val Glu Ser Thr Leu Arg Arg Lys Tyr Thr Leu Ile Asp 
        435                 440                 445             


Arg Asn Asp Phe Ala Ala Ile Ser Ala Ile Gln Lys Ala Gly Leu Val 
    450                 455                 460                 


Asp Val Asp Gly His Leu Val Gly Glu Pro Glu Gly Gln Asn Phe Gly 
465                 470                 475                 480 


Leu Gly Val Ala Pro Phe Ser Thr Lys Pro Gly Lys Lys Ala Lys Ser 
                485                 490                 495     


Lys Lys Thr Phe Lys Glu Pro Leu Ser Ser Leu Ala Arg Lys Glu Gly 
            500                 505                 510         


Ala Ser Ser Pro Val Asn Gly Lys Asp Leu Asp Tyr Val Ser Thr Ser 
        515                 520                 525             


Lys Thr Gln Leu Val Pro Ser Ser Lys Asp Gly Asp Val Lys Asp Met 
    530                 535                 540                 


Leu Ser Arg Asp Arg Glu Thr Ser Ser Ile Glu Pro Leu Pro Ser Asp 
545                 550                 555                 560 


Ser Pro Lys Glu Glu Leu Arg Pro Ile Arg Pro Asp Thr Pro Pro Ser 
                565                 570                 575     


Lys Pro Val Ala Phe Glu Glu Phe Lys Asn Glu Gln Gly Ser Glu Ile 
            580                 585                 590         


Asn Arg Ile Phe Lys Glu Asn Lys Ser Ile Leu Asn Glu Arg Arg Lys 
        595                 600                 605             


Arg Ala Ser Glu Thr Thr Gln His Ile Asn Ala Ile Lys Arg Glu Ile 
    610                 615                 620                 


Asp Val Thr Lys Glu Ala Leu Asn Phe Gln Lys Ser Leu Arg Glu Lys 
625                 630                 635                 640 


Gln Gly Lys Tyr Glu Asn Lys Gly Leu Met Ile Ile Asp Glu Glu Glu 
                645                 650                 655     


Phe Leu Leu Ile Leu Lys Leu Lys Asp Leu Lys Lys Gln Tyr Arg Ser 
            660                 665                 670         


Glu Tyr Gln Asp Leu Arg Asp Leu Arg Ala Glu Ile Gln Tyr Cys Gln 
        675                 680                 685             


His Leu Val Asp Gln Cys Arg His Arg Leu Leu Met Glu Phe Asp Ile 
    690                 695                 700                 


Trp Tyr Asn Glu Ser Phe Val Ile Pro Glu Asp Met Gln Met Ala Leu 
705                 710                 715                 720 


Lys Pro Gly Gly Ser Ile Arg Pro Gly Met Val Pro Val Asn Arg Ile 
                725                 730                 735     


Val Ser Leu Gly Glu Asp Asp Gln Asp Lys Phe Ser Gln Leu Gln Gln 
            740                 745                 750         


Arg Val Leu Pro Glu Gly Pro Asp Ser Ile Ser Phe Tyr Asn Ala Lys 
        755                 760                 765             


Val Lys Ile Glu Gln Lys His Asn Tyr Leu Lys Thr Met Met Gly Leu 
    770                 775                 780                 


Gln Gln Ala His Arg Lys 
785                 790 


<210>  5901
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIFAP3__Homo_sapiens__NP_001191443

<400>  5901

Met Ser Ile Ala Leu Gly Asn Thr Tyr Arg Arg Ser Leu Ser Asp Ser 
1               5                   10                  15      


Glu Thr Val Ser Val Leu Gln Ala Ser Leu Cys Glu Glu Lys Lys Glu 
            20                  25                  30          


Lys Ser Ser Lys Pro Lys Asp Pro Pro Pro Phe Glu Gly Met Glu Ile 
        35                  40                  45              


Asp Glu Val Ala Asn Ile Asn Asp Met Asp Glu Tyr Ile Glu Leu Leu 
    50                  55                  60                  


Tyr Glu Asp Ile Pro Asp Lys Val Arg Gly Ser Ala Leu Ile Leu Gln 
65                  70                  75                  80  


Leu Ala Arg Asn Pro Asp Asn Leu Glu Glu Leu Leu Leu Asn Glu Thr 
                85                  90                  95      


Ala Leu Gly Ala Leu Ala Arg Val Leu Arg Glu Asp Trp Lys Gln Ser 
            100                 105                 110         


Val Glu Leu Ala Thr Asn Ile Ile Tyr Ile Phe Phe Cys Phe Ser Ser 
        115                 120                 125             


Phe Ser Gln Phe His Gly Leu Ile Thr His Tyr Lys Ile Gly Ala Leu 
    130                 135                 140                 


Cys Met Asn Ile Ile Asp His Glu Leu Lys Arg His Glu Leu Trp Gln 
145                 150                 155                 160 


Glu Glu Leu Ser Lys Lys Lys Lys Ala Val Asp Glu Asp Pro Glu Asn 
                165                 170                 175     


Gln Thr Leu Arg Lys Asp Tyr Glu Lys Thr Phe Lys Lys Tyr Gln Gly 
            180                 185                 190         


Leu Val Val Lys Gln Glu Gln Leu Leu Arg Val Ala Leu Tyr Leu Leu 
        195                 200                 205             


Leu Asn Leu Ala Glu Asp Thr Arg Thr Glu Leu Lys Met Arg Asn Lys 
    210                 215                 220                 


Asn Ile Val His Met Leu Val Lys Ala Leu Asp Arg Asp Asn Phe Glu 
225                 230                 235                 240 


Leu Leu Ile Leu Val Val Ser Phe Leu Lys Lys Leu Ser Ile Phe Met 
                245                 250                 255     


Glu Asn Lys Asn Asp Met Val Glu Met Asp Ile Val Glu Lys Leu Val 
            260                 265                 270         


Lys Met Ile Pro Cys Glu His Glu Asp Leu Leu Asn Ile Thr Leu Arg 
        275                 280                 285             


Leu Leu Leu Asn Leu Ser Phe Asp Thr Gly Leu Arg Asn Lys Met Val 
    290                 295                 300                 


Gln Val Gly Leu Leu Pro Lys Leu Thr Ala Leu Leu Gly Asn Asp Asn 
305                 310                 315                 320 


Tyr Lys Gln Ile Ala Met Cys Val Leu Tyr His Ile Ser Met Asp Asp 
                325                 330                 335     


Arg Phe Lys Ser Met Phe Ala Tyr Thr Asp Cys Ile Pro Gln Leu Met 
            340                 345                 350         


Lys Met Leu Phe Glu Cys Ser Asp Glu Arg Ile Asp Leu Glu Leu Ile 
        355                 360                 365             


Ser Phe Cys Ile Asn Leu Ala Ala Asn Lys Arg Asn Val Gln Leu Ile 
    370                 375                 380                 


Cys Glu Gly Asn Gly Leu Lys Met Leu Met Lys Arg Ala Leu Lys Phe 
385                 390                 395                 400 


Lys Asp Pro Leu Leu Met Lys Met Ile Arg Asn Ile Ser Gln His Asp 
                405                 410                 415     


Gly Pro Thr Lys Asn Leu Phe Ile Asp Tyr Val Gly Asp Leu Ala Ala 
            420                 425                 430         


Gln Ile Ser Asn Asp Glu Glu Glu Glu Phe Val Ile Glu Cys Leu Gly 
        435                 440                 445             


Thr Leu Ala Asn Leu Thr Ile Pro Asp Leu Asp Trp Glu Leu Val Leu 
    450                 455                 460                 


Lys Glu Tyr Lys Leu Val Pro Tyr Leu Lys Asp Lys Leu Lys Pro Gly 
465                 470                 475                 480 


Ala Ala Glu Asp Asp Leu Val Leu Glu Val Val Ile Met Ile Gly Thr 
                485                 490                 495     


Val Ser Met Asp Asp Ser Cys Ala Ala Leu Leu Ala Lys Ser Gly Ile 
            500                 505                 510         


Ile Pro Ala Leu Ile Glu Leu Leu Asn Ala Gln Gln Glu Asp Asp Glu 
        515                 520                 525             


Phe Val Cys Gln Ile Ile Tyr Val Phe Tyr Gln Met Val Phe His Gln 
    530                 535                 540                 


Ala Thr Arg Asp Val Ile Ile Lys Glu Thr Gln Ala Pro Ala Tyr Leu 
545                 550                 555                 560 


Ile Asp Leu Met His Asp Lys Asn Asn Glu Ile Arg Lys Val Cys Asp 
                565                 570                 575     


Asn Thr Leu Asp Ile Ile Ala Glu Tyr Asp Glu Glu Trp Ala Lys Lys 
            580                 585                 590         


Ile Gln Ser Glu Lys Phe Arg Trp His Asn Ser Gln Trp Leu Glu Met 
        595                 600                 605             


Val Glu Ser Arg Gln Met Asp Glu Ser Glu Gln Tyr Leu Tyr Gly Asp 
    610                 615                 620                 


Asp Arg Ile Glu Pro Tyr Ile His Glu Gly Asp Ile Leu Glu Arg Pro 
625                 630                 635                 640 


Asp Leu Phe Tyr Asn Ser Asp Gly Leu Ile Ala Ser Glu Gly Ala Ile 
                645                 650                 655     


Ser Pro Asp Phe Phe Asn Asp Tyr His Leu Gln Asn Gly Asp Val Val 
            660                 665                 670         


Gly Gln His Ser Phe Pro Gly Ser Leu Gly Met Asp Gly Phe Gly Gln 
        675                 680                 685             


Pro Val Gly Ile Leu Gly Arg Pro Ala Thr Ala Tyr Gly Phe Arg Pro 
    690                 695                 700                 


Asp Glu Pro Tyr Tyr Tyr Gly Tyr Gly Ser 
705                 710                 


<210>  5902
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIFC1__Homo_sapiens__NP_002254

<400>  5902

Met Asp Pro Gln Arg Ser Pro Leu Leu Glu Val Lys Gly Asn Ile Glu 
1               5                   10                  15      


Leu Lys Arg Pro Leu Ile Lys Ala Pro Ser Gln Leu Pro Leu Ser Gly 
            20                  25                  30          


Ser Arg Leu Lys Arg Arg Pro Asp Gln Met Glu Asp Gly Leu Glu Pro 
        35                  40                  45              


Glu Lys Lys Arg Thr Arg Gly Leu Gly Ala Thr Thr Lys Ile Thr Thr 
    50                  55                  60                  


Ser His Pro Arg Val Pro Ser Leu Thr Thr Val Pro Gln Thr Gln Gly 
65                  70                  75                  80  


Gln Thr Thr Ala Gln Lys Val Ser Lys Lys Thr Gly Pro Arg Cys Ser 
                85                  90                  95      


Thr Ala Ile Ala Thr Gly Leu Lys Asn Gln Lys Pro Val Pro Ala Val 
            100                 105                 110         


Pro Val Gln Lys Ser Gly Thr Ser Gly Val Pro Pro Met Ala Gly Gly 
        115                 120                 125             


Lys Lys Pro Ser Lys Arg Pro Ala Trp Asp Leu Lys Gly Gln Leu Cys 
    130                 135                 140                 


Asp Leu Asn Ala Glu Leu Lys Arg Cys Arg Glu Arg Thr Gln Thr Leu 
145                 150                 155                 160 


Asp Gln Glu Asn Gln Gln Leu Gln Asp Gln Leu Arg Asp Ala Gln Gln 
                165                 170                 175     


Gln Val Lys Ala Leu Gly Thr Glu Arg Thr Thr Leu Glu Gly His Leu 
            180                 185                 190         


Ala Lys Val Gln Ala Gln Ala Glu Gln Gly Gln Gln Glu Leu Lys Asn 
        195                 200                 205             


Leu Arg Ala Cys Val Leu Glu Leu Glu Glu Arg Leu Ser Thr Gln Glu 
    210                 215                 220                 


Gly Leu Val Gln Glu Leu Gln Lys Lys Gln Val Glu Leu Gln Glu Glu 
225                 230                 235                 240 


Arg Arg Gly Leu Met Ser Gln Leu Glu Glu Lys Glu Arg Arg Leu Gln 
                245                 250                 255     


Thr Ser Glu Ala Ala Leu Ser Ser Ser Gln Ala Glu Val Ala Ser Leu 
            260                 265                 270         


Arg Gln Glu Thr Val Ala Gln Ala Ala Leu Leu Thr Glu Arg Glu Glu 
        275                 280                 285             


Arg Leu His Gly Leu Glu Met Glu Arg Arg Arg Leu His Asn Gln Leu 
    290                 295                 300                 


Gln Glu Leu Lys Gly Asn Ile Arg Val Phe Cys Arg Val Arg Pro Val 
305                 310                 315                 320 


Leu Pro Gly Glu Pro Thr Pro Pro Pro Gly Leu Leu Leu Phe Pro Ser 
                325                 330                 335     


Gly Pro Gly Gly Pro Ser Asp Pro Pro Thr Arg Leu Ser Leu Ser Arg 
            340                 345                 350         


Ser Asp Glu Arg Arg Gly Thr Leu Ser Gly Ala Pro Ala Pro Pro Thr 
        355                 360                 365             


Arg His Asp Phe Ser Phe Asp Arg Val Phe Pro Pro Gly Ser Gly Gln 
    370                 375                 380                 


Asp Glu Val Phe Glu Glu Ile Ala Met Leu Val Gln Ser Ala Leu Asp 
385                 390                 395                 400 


Gly Tyr Pro Val Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys 
                405                 410                 415     


Thr Phe Thr Met Glu Gly Gly Pro Gly Gly Asp Pro Gln Leu Glu Gly 
            420                 425                 430         


Leu Ile Pro Arg Ala Leu Arg His Leu Phe Ser Val Ala Gln Glu Leu 
        435                 440                 445             


Ser Gly Gln Gly Trp Thr Tyr Ser Phe Val Ala Ser Tyr Val Glu Ile 
    450                 455                 460                 


Tyr Asn Glu Thr Val Arg Asp Leu Leu Ala Thr Gly Thr Arg Lys Gly 
465                 470                 475                 480 


Gln Gly Gly Glu Cys Glu Ile Arg Arg Ala Gly Pro Gly Ser Glu Glu 
                485                 490                 495     


Leu Thr Val Thr Asn Ala Arg Tyr Val Pro Val Ser Cys Glu Lys Glu 
            500                 505                 510         


Val Asp Ala Leu Leu His Leu Ala Arg Gln Asn Arg Ala Val Ala Arg 
        515                 520                 525             


Thr Ala Gln Asn Glu Arg Ser Ser Arg Ser His Ser Val Phe Gln Leu 
    530                 535                 540                 


Gln Ile Ser Gly Glu His Ser Ser Arg Gly Leu Gln Cys Gly Ala Pro 
545                 550                 555                 560 


Leu Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Leu Asp Pro Gly Leu 
                565                 570                 575     


Ala Leu Gly Pro Gly Glu Arg Glu Arg Leu Arg Glu Thr Gln Ala Ile 
            580                 585                 590         


Asn Ser Ser Leu Ser Thr Leu Gly Leu Val Ile Met Ala Leu Ser Asn 
        595                 600                 605             


Lys Glu Ser His Val Pro Tyr Arg Asn Ser Lys Leu Thr Tyr Leu Leu 
    610                 615                 620                 


Gln Asn Ser Leu Gly Gly Ser Ala Lys Met Leu Met Phe Val Asn Ile 
625                 630                 635                 640 


Ser Pro Leu Glu Glu Asn Val Ser Glu Ser Leu Asn Ser Leu Arg Phe 
                645                 650                 655     


Ala Ser Lys Val Asn Gln Cys Val Ile Gly Thr Ala Gln Ala Asn Arg 
            660                 665                 670         


Lys 
    


<210>  5903
<211>  826
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIFC3__Homo_sapiens__NP_001123572

<400>  5903

Met Val Pro Ser Arg Arg Thr Trp Asn Leu Gly Ala Thr Pro Ser Leu 
1               5                   10                  15      


Arg Gly Leu Trp Arg Val Gly Arg Ala Pro Glu Pro Glu Pro Gly Met 
            20                  25                  30          


Ala Arg Pro Ala Pro Ala Pro Ala Ser Pro Ala Ala Arg Pro Phe Pro 
        35                  40                  45              


His Thr Gly Pro Gly Arg Leu Arg Thr Gly Arg Gly Lys Asp Thr Pro 
    50                  55                  60                  


Val Cys Gly Asp Glu Asp Ser Ser Ala Arg Ser Ala Ala Arg Pro Ala 
65                  70                  75                  80  


Leu Ala Gln Cys Arg Ala Leu Ser Val Asp Trp Ala Gly Pro Gly Ser 
                85                  90                  95      


Pro His Gly Leu Tyr Leu Thr Leu Gln Val Glu His Leu Lys Glu Lys 
            100                 105                 110         


Leu Ile Ser Gln Ala Gln Glu Val Ser Arg Leu Arg Ser Glu Leu Gly 
        115                 120                 125             


Gly Thr Asp Leu Glu Lys His Arg Asp Leu Leu Met Val Glu Asn Glu 
    130                 135                 140                 


Arg Leu Arg Gln Glu Met Arg Arg Cys Glu Ala Glu Leu Gln Glu Leu 
145                 150                 155                 160 


Arg Thr Lys Pro Ala Gly Pro Cys Pro Gly Cys Glu His Ser Gln Glu 
                165                 170                 175     


Ser Ala Gln Leu Arg Asp Lys Leu Ser Gln Leu Gln Leu Glu Met Ala 
            180                 185                 190         


Glu Ser Lys Gly Met Leu Ser Glu Leu Asn Leu Glu Val Gln Gln Lys 
        195                 200                 205             


Thr Asp Arg Leu Ala Glu Val Glu Leu Arg Leu Lys Asp Cys Leu Ala 
    210                 215                 220                 


Glu Lys Ala Gln Glu Glu Glu Arg Leu Ser Arg Arg Leu Arg Asp Ser 
225                 230                 235                 240 


His Glu Thr Ile Ala Ser Leu Arg Ala Gln Ser Pro Pro Val Lys Tyr 
                245                 250                 255     


Val Ile Lys Thr Val Glu Val Glu Ser Ser Lys Thr Lys Gln Ala Leu 
            260                 265                 270         


Ser Glu Ser Gln Ala Arg Asn Gln His Leu Gln Glu Gln Val Ala Met 
        275                 280                 285             


Gln Arg Gln Val Leu Lys Glu Met Glu Gln Gln Leu Gln Ser Ser His 
    290                 295                 300                 


Gln Leu Thr Ala Arg Leu Arg Ala Gln Ile Ala Met Tyr Glu Ser Glu 
305                 310                 315                 320 


Leu Glu Arg Ala His Gly Gln Met Leu Glu Glu Met Gln Ser Leu Glu 
                325                 330                 335     


Glu Asp Lys Asn Arg Ala Ile Glu Glu Ala Phe Ala Arg Ala Gln Val 
            340                 345                 350         


Glu Met Lys Ala Val His Glu Asn Leu Ala Gly Val Arg Thr Asn Leu 
        355                 360                 365             


Leu Thr Leu Gln Pro Ala Leu Arg Thr Leu Thr Asn Asp Tyr Asn Gly 
    370                 375                 380                 


Leu Lys Arg Gln Val Arg Gly Phe Pro Leu Leu Leu Gln Glu Ala Leu 
385                 390                 395                 400 


Arg Ser Val Lys Ala Glu Ile Gly Gln Ala Ile Glu Glu Val Asn Ser 
                405                 410                 415     


Asn Asn Gln Glu Leu Leu Arg Lys Tyr Arg Arg Glu Leu Gln Leu Arg 
            420                 425                 430         


Lys Lys Cys His Asn Glu Leu Val Arg Leu Lys Gly Asn Ile Arg Val 
        435                 440                 445             


Ile Ala Arg Val Arg Pro Val Thr Lys Glu Asp Gly Glu Gly Pro Glu 
    450                 455                 460                 


Ala Thr Asn Ala Val Thr Phe Asp Ala Asp Asp Asp Ser Ile Ile His 
465                 470                 475                 480 


Leu Leu His Lys Gly Lys Pro Val Ser Phe Glu Leu Asp Lys Val Phe 
                485                 490                 495     


Ser Pro Gln Ala Ser Gln Gln Asp Val Phe Gln Glu Val Gln Ala Leu 
            500                 505                 510         


Val Thr Ser Cys Ile Asp Gly Phe Asn Val Cys Ile Phe Ala Tyr Gly 
        515                 520                 525             


Gln Thr Gly Ala Gly Lys Thr Tyr Thr Met Glu Gly Thr Ala Glu Asn 
    530                 535                 540                 


Pro Gly Ile Asn Gln Arg Ala Leu Gln Leu Leu Phe Ser Glu Val Gln 
545                 550                 555                 560 


Glu Lys Ala Ser Asp Trp Glu Tyr Thr Ile Thr Val Ser Ala Ala Glu 
                565                 570                 575     


Ile Tyr Asn Glu Val Leu Arg Asp Leu Leu Gly Lys Glu Pro Gln Glu 
            580                 585                 590         


Lys Leu Glu Ile Arg Leu Cys Pro Asp Gly Ser Gly Gln Leu Tyr Val 
        595                 600                 605             


Pro Gly Leu Thr Glu Phe Gln Val Gln Ser Val Asp Asp Ile Asn Lys 
    610                 615                 620                 


Val Phe Glu Phe Gly His Thr Asn Arg Thr Thr Glu Phe Thr Asn Leu 
625                 630                 635                 640 


Asn Glu His Ser Ser Arg Ser His Ala Leu Leu Ile Val Thr Val Arg 
                645                 650                 655     


Gly Val Asp Cys Ser Thr Gly Leu Arg Thr Thr Gly Lys Leu Asn Leu 
            660                 665                 670         


Val Asp Leu Ala Gly Ser Glu Arg Val Gly Lys Ser Gly Ala Glu Gly 
        675                 680                 685             


Ser Arg Leu Arg Glu Ala Gln His Ile Asn Lys Ser Leu Ser Ala Leu 
    690                 695                 700                 


Gly Asp Val Ile Ala Ala Leu Arg Ser Arg Gln Gly His Val Pro Phe 
705                 710                 715                 720 


Arg Asn Ser Lys Leu Thr Tyr Leu Leu Gln Asp Ser Leu Ser Gly Asp 
                725                 730                 735     


Ser Lys Thr Leu Met Val Val Gln Val Ser Pro Val Glu Lys Asn Thr 
            740                 745                 750         


Ser Glu Thr Leu Tyr Ser Leu Lys Phe Ala Glu Arg Val Arg Ser Val 
        755                 760                 765             


Glu Leu Gly Pro Gly Leu Arg Arg Ala Glu Leu Gly Ser Trp Ser Ser 
    770                 775                 780                 


Gln Glu His Leu Glu Trp Glu Pro Ala Cys Gln Thr Pro Gln Pro Ser 
785                 790                 795                 800 


Ala Arg Ala His Ser Ala Pro Ser Ser Gly Thr Ser Ser Arg Pro Gly 
                805                 810                 815     


Ser Ile Arg Arg Lys Leu Gln Pro Ser Ala 
            820                 825     


<210>  5904
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIN__Homo_sapiens__NP_036443

<400>  5904

Met Gly Lys Ser Asp Phe Leu Thr Pro Lys Ala Ile Ala Asn Arg Ile 
1               5                   10                  15      


Lys Ser Lys Gly Leu Gln Lys Leu Arg Trp Tyr Cys Gln Met Cys Gln 
            20                  25                  30          


Lys Gln Cys Arg Asp Glu Asn Gly Phe Lys Cys His Cys Met Ser Glu 
        35                  40                  45              


Ser His Gln Arg Gln Leu Leu Leu Ala Ser Glu Asn Pro Gln Gln Phe 
    50                  55                  60                  


Met Asp Tyr Phe Ser Glu Glu Phe Arg Asn Asp Phe Leu Glu Leu Leu 
65                  70                  75                  80  


Arg Arg Arg Phe Gly Thr Lys Arg Val His Asn Asn Ile Val Tyr Asn 
                85                  90                  95      


Glu Tyr Ile Ser His Arg Glu His Ile His Met Asn Ala Thr Gln Trp 
            100                 105                 110         


Glu Thr Leu Thr Asp Phe Thr Lys Trp Leu Gly Arg Glu Gly Leu Cys 
        115                 120                 125             


Lys Val Asp Glu Thr Pro Lys Gly Trp Tyr Ile Gln Tyr Ile Asp Arg 
    130                 135                 140                 


Asp Pro Glu Thr Ile Arg Arg Gln Leu Glu Leu Glu Lys Lys Lys Lys 
145                 150                 155                 160 


Gln Asp Leu Asp Asp Glu Glu Lys Thr Ala Lys Phe Ile Glu Glu Gln 
                165                 170                 175     


Val Arg Arg Gly Leu Glu Gly Lys Glu Gln Glu Val Pro Thr Phe Thr 
            180                 185                 190         


Glu Leu Ser Arg Glu Asn Asp Glu Glu Lys Val Thr Phe Asn Leu Ser 
        195                 200                 205             


Lys Gly Ala Cys Ser Ser Ser Gly Ala Thr Ser Ser Lys Ser Ser Thr 
    210                 215                 220                 


Leu Gly Pro Ser Ala Leu Lys Thr Ile Gly Ser Ser Ala Ser Val Lys 
225                 230                 235                 240 


Arg Lys Glu Ser Ser Gln Ser Ser Thr Gln Ser Lys Glu Lys Lys Lys 
                245                 250                 255     


Lys Lys Ser Ala Leu Asp Glu Ile Met Glu Ile Glu Glu Glu Lys Lys 
            260                 265                 270         


Arg Thr Ala Arg Thr Asp Tyr Trp Leu Gln Pro Glu Ile Ile Val Lys 
        275                 280                 285             


Ile Ile Thr Lys Lys Leu Gly Glu Lys Tyr His Lys Lys Lys Ala Ile 
    290                 295                 300                 


Val Lys Glu Val Ile Asp Lys Tyr Thr Ala Val Val Lys Met Ile Asp 
305                 310                 315                 320 


Ser Gly Asp Lys Leu Lys Leu Asp Gln Thr His Leu Glu Thr Val Ile 
                325                 330                 335     


Pro Ala Pro Gly Lys Arg Ile Leu Val Leu Asn Gly Gly Tyr Arg Gly 
            340                 345                 350         


Asn Glu Gly Thr Leu Glu Ser Ile Asn Glu Lys Thr Phe Ser Ala Thr 
        355                 360                 365             


Ile Val Ile Glu Thr Gly Pro Leu Lys Gly Arg Arg Val Glu Gly Ile 
    370                 375                 380                 


Gln Tyr Glu Asp Ile Ser Lys Leu Ala 
385                 390             


<210>  5905
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL1__Homo_sapiens__NP_055033

<400>  5905

Met Ser Leu Leu Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Met Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Ser Arg Met Thr Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Val Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Leu Gly Pro Thr Val Leu Ala Gly Glu Asn 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys 
            260                 265                 270         


Asn Ala Ala Val Met Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn 
        275                 280                 285             


Ser Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln 
    290                 295                 300                 


Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln 
305                 310                 315                 320 


Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro 
                325                 330                 335     


Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro 
            340                 345             


<210>  5906
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL2__Homo_sapiens__NP_055034

<400>  5906

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Cys Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys 
            260                 265                 270         


Asn Ala Ala Val Met Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn 
        275                 280                 285             


Ser Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln 
    290                 295                 300                 


Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln 
305                 310                 315                 320 


Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro 
                325                 330                 335     


Asn Ala Glu Ser Arg Ser Lys Val Val Ser Cys Pro 
            340                 345             


<210>  5907
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL3__Homo_sapiens__NP_056952

<400>  5907

Met Ser Leu Met Val Val Ser Met Val Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Gln His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Leu 
                245                 250                 255     


Phe Ile Leu Leu Leu Phe Phe Leu Leu His Arg Trp Cys Cys Asn Lys 
            260                 265                 270         


Lys Asn Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Arg Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala 
    290                 295                 300                 


Gln Leu Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser 
305                 310                 315                 320 


Gln Arg Pro Lys Thr Pro Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu 
                325                 330                 335     


Pro Asn Ala Glu Pro 
            340     


<210>  5908
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL4__Homo_sapiens__NP_001074239

<400>  5908

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser 
    210                 215                 220                 


Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Asp Ala Ala Val Met 
225                 230                 235                 240 


Asn Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu Asp Ser Asp 
                245                 250                 255     


Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Ile 
            260                 265                 270         


Phe Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser Lys Arg Pro 
        275                 280                 285             


Ser Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala Glu Pro Arg 
    290                 295                 300                 


Ala Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu Met Gly Ser 
305                 310                 315                 320 


Ser Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala Ser Ser Asn 
                325                 330                 335     


Val Pro Ala Ala Gly Ile 
            340         


<210>  5909
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL5A__Homo_sapiens__NP_065396

<400>  5909

Met Ser Leu Met Val Ile Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Thr His Glu Gly Gly Gln Asp Lys Pro Leu Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Ala Val Val Pro Arg Gly Gly His Val Thr Leu Leu 
        35                  40                  45              


Cys Arg Ser Arg Leu Gly Phe Thr Ile Phe Ser Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Gly Val Pro Val Pro Glu Leu Tyr Asn Lys Ile Phe Trp Lys Ser Ile 
65                  70                  75                  80  


Leu Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser His Pro Arg Ser Pro Ile Glu Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Val Val Thr Gly Leu Phe Gly Lys Pro Ser Leu Ser Ala 
        115                 120                 125             


Gln Pro Gly Pro Thr Val Arg Thr Gly Glu Asn Val Thr Leu Ser Cys 
    130                 135                 140                 


Ser Ser Arg Ser Ser Phe Asp Met Tyr His Leu Ser Arg Glu Gly Arg 
145                 150                 155                 160 


Ala His Glu Pro Arg Leu Pro Ala Val Pro Ser Val Asn Gly Thr Phe 
                165                 170                 175     


Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Thr 
            180                 185                 190         


Cys Phe Gly Ser Leu His Asp Ser Pro Tyr Glu Trp Ser Asp Pro Ser 
        195                 200                 205             


Asp Pro Leu Leu Val Ser Val Thr Gly Asn Ser Ser Ser Ser Ser Ser 
    210                 215                 220                 


Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Ile Arg Arg His Leu His 
225                 230                 235                 240 


Ile Leu Ile Gly Thr Ser Val Ala Ile Ile Leu Phe Ile Ile Leu Phe 
                245                 250                 255     


Phe Phe Leu Leu His Cys Cys Cys Ser Asn Lys Lys Asn Ala Ala Val 
            260                 265                 270         


Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn Arg Glu Asp Ser 
        275                 280                 285             


Asp Asp Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys 
    290                 295                 300                 


Val Phe Thr Gln Thr Lys Ile Thr Ser Pro Ser Gln Arg Pro Lys Thr 
305                 310                 315                 320 


Pro Pro Thr Asp Thr Thr Met Tyr Met Glu Leu Pro Asn Ala Lys Pro 
                325                 330                 335     


Arg Ser Leu Ser Pro Ala His Lys His His Ser Gln Ala Leu Arg Gly 
            340                 345                 350         


Ser Ser Arg Glu Thr Thr Ala Leu Ser Gln Asn Arg Val Ala Ser Ser 
        355                 360                 365             


His Val Pro Ala Ala Gly Ile 
    370                 375 


<210>  5910
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL5B__Homo_sapiens__NP_001018091

<400>  5910

Met Ser Leu Met Val Ile Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Thr His Glu Gly Gly Gln Asp Lys Pro Leu Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Ala Val Val Pro Arg Gly Gly His Val Thr Leu Leu 
        35                  40                  45              


Cys Arg Ser Arg Leu Gly Phe Thr Ile Phe Ser Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Gly Val Pro Val Pro Glu Leu Tyr Asn Lys Ile Phe Trp Lys Ser Ile 
65                  70                  75                  80  


Leu Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser His Pro Arg Ser Pro Ile Glu Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Val Val Thr Gly Leu Phe Gly Lys Pro Ser Leu Ser Ala 
        115                 120                 125             


Gln Pro Gly Pro Thr Val Arg Thr Gly Glu Asn Val Ala Leu Ser Cys 
    130                 135                 140                 


Ser Ser Arg Ser Ser Phe Asp Met Tyr His Leu Ser Arg Glu Gly Arg 
145                 150                 155                 160 


Ala His Glu Pro Arg Leu Pro Ala Val Pro Ser Val Asp Gly Thr Phe 
                165                 170                 175     


Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Gly Thr Tyr Thr 
            180                 185                 190         


Cys Phe Ser Ser Leu His Asp Ser Pro Tyr Glu Trp Ser Asp Pro Ser 
        195                 200                 205             


Asp Pro Leu Leu Val Ser Val Thr Gly Asn Ser Ser Ser Ser Ser Ser 
    210                 215                 220                 


Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Ile Arg Arg His Leu His 
225                 230                 235                 240 


Ile Leu Ile Gly Thr Ser Val Ala Ile Ile Leu Phe Ile Ile Leu Phe 
                245                 250                 255     


Phe Phe Leu Leu His Cys Cys Cys Ser Asn Lys Lys Asn Ala Ala Val 
            260                 265                 270         


Met Asp Gln Gly Pro Ala Gly Asp Arg Thr Val Asn Arg Glu Asp Ser 
        275                 280                 285             


Asp Asp Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys 
    290                 295                 300                 


Val Phe Thr Gln Thr Lys Ile Thr Ser Pro Ser Gln Arg Pro Lys Ala 
305                 310                 315                 320 


Pro Pro Thr Asp Thr Thr Met Tyr Met Glu Leu Pro Asn Ala Lys Pro 
                325                 330                 335     


Arg Ser Leu Ser Pro Ala His Lys His His Ser Gln Ala Leu Arg Gly 
            340                 345                 350         


Ser Ser Arg Glu Thr Thr Ala Leu Ser Gln Asn Arg Val Ala Ser Ser 
        355                 360                 365             


His Val Pro Ala Ala Gly Ile 
    370                 375 


<210>  5911
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DS1__Homo_sapiens__NP_055327

<400>  5911

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Met Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Ser Arg Met Lys Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Asn 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Gly Thr Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asn Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Glu Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210>  5912
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DS2__Homo_sapiens__NP_001278624

<400>  5912

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Val His Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Pro Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Arg Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Tyr Lys Asp Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Thr His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asn Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Arg Glu Ile Thr Arg Pro Ser Glu Arg Pro Lys Thr Pro 
    290                 295                 300                 


Pro Thr Asp Thr Ser Met Tyr Ile Glu Leu Pro Asn Ala Glu Pro Arg 
305                 310                 315                 320 


Ser Lys Val Val Phe Cys Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly 
                325                 330                 335     


Ile Phe 
        


<210>  5913
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DS3__Homo_sapiens__NP_036445

<400>  5913

Met Ser Leu Met Val Ile Ser Met Ala Cys Val Gly Phe Phe Trp Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro His Glu Gly Phe Arg Arg Lys Pro Ser Leu Leu 
            20                  25                  30          


Ala His Pro Gly Arg Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Thr Phe Asn Asp Thr Leu Arg Leu Ile Gly Glu His Ile Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Arg Met Arg Gln Asp Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Phe Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Leu Ala Gly Glu Ser 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Thr Glu Gly Glu Ala His Glu Arg Arg Phe Ser Ala Gly Pro Lys 
                165                 170                 175     


Val Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr Gln 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Asp Ser Pro Tyr Glu 
        195                 200                 205             


Trp Ser Lys Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Leu Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys 
            260                 265                 270         


Lys Asn Ala Ser Val Met Asp Gln Gly Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Arg Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210>  5914
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DS4__Homo_sapiens__NP_036446

<400>  5914

Met Ser Leu Met Val Ile Ile Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Gln Glu Gly Val His Arg Lys Pro Ser Phe Leu 
            20                  25                  30          


Ala Leu Pro Gly His Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Asn Asn Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Met Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Val Arg Ser 
                165                 170                 175     


Ile Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ala Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


<210>  5915
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR3DL1__Homo_sapiens__NP_037421

<400>  5915

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Leu Phe Leu Val 
1               5                   10                  15      


Gln Arg Ala Gly Pro His Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Ala Val Val Pro Arg Gly Gly His Val Thr Leu Arg 
        35                  40                  45              


Cys His Tyr Arg His Arg Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ile His Ile Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Asn Met Ser Pro Val Thr Thr Ala His Ala Gly Asn Tyr Thr Cys Arg 
                85                  90                  95      


Gly Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Val Lys Ser Gly Glu Arg Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Ile Met Phe Glu His Phe Phe Leu His Lys Glu Gly Ile 
145                 150                 155                 160 


Ser Lys Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Met Met Leu Ala Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Thr His Thr Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Val Thr Gly Pro Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Lys Val Gln Ala Gly Glu Ser Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Gly Ala His Glu Arg Arg Leu Pro Ala Val Arg Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg His Ser Pro Tyr Glu Trp 
    290                 295                 300                 


Ser Asp Pro Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Asn Pro 
                325                 330                 335     


Arg His Leu His Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu His Leu Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Ala Asn 
    370                 375                 380                 


Ser Glu Asp Ser Asp Glu Gln Asp Pro Glu Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Pro Thr Asp Thr Ile Leu Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Lys Pro Arg Ser Lys Val Val Ser Cys Pro 
        435                 440                 


<210>  5916
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR3DL2__Homo_sapiens__NP_001229796

<400>  5916

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Ile Cys Arg 
305                 310                 315                 320 


His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe Ile 
                325                 330                 335     


Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys Asn 
            340                 345                 350         


Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn Arg 
        355                 360                 365             


Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
    370                 375                 380                 


Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln Arg 
385                 390                 395                 400 


Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro Asn 
                405                 410                 415     


Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln Ser 
            420                 425                 430         


Gly Leu Glu Gly Val Phe 
        435             


<210>  5917
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR3DL3__Homo_sapiens__NP_703144

<400>  5917

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Glu Gly Pro Trp Pro His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Trp Pro Gly Thr Val Val Ser Glu Gly Gln His Val Thr Leu Gln 
        35                  40                  45              


Cys Arg Ser Arg Leu Gly Phe Asn Glu Phe Ser Leu Ser Lys Glu Asp 
    50                  55                  60                  


Gly Met Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Arg Asn Ser Phe 
65                  70                  75                  80  


Leu Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Cys 
                85                  90                  95      


Ser Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Val His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Val Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Arg Phe Glu Arg Phe Leu Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Thr Glu Asp Pro Leu Arg Leu Val Gly Gln Leu His Asp Ala Gly Ser 
                165                 170                 175     


Gln Val Asn Tyr Ser Met Gly Pro Met Thr Pro Ala Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Val Thr His Leu Pro Tyr Glu Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Val Val Gly Leu Tyr Gly Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Arg Ser Leu Phe Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Ala Glu Ala Gly Glu Leu Arg Leu Thr Ala Val Leu Arg Val 
            260                 265                 270         


Asn Gly Thr Phe Gln Ala Asn Phe Pro Leu Gly Pro Val Thr His Gly 
        275                 280                 285             


Gly Asn Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro His Ala Trp 
    290                 295                 300                 


Ser Asp Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Ser Arg 
305                 310                 315                 320 


Asn Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Pro Phe Ala 
                325                 330                 335     


Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ala Asn Lys Lys Asn 
            340                 345                 350         


Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val Asn Arg 
        355                 360                 365             


Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
    370                 375                 380                 


Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg 
385                 390                 395                 400 


Pro Lys Thr Pro Pro Thr Asp Thr Ser Val 
                405                 410 


<210>  5918
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIRREL2__Homo_sapiens__NP_115499

<400>  5918

Met Leu Arg Met Arg Val Pro Ala Leu Leu Val Leu Leu Phe Cys Phe 
1               5                   10                  15      


Arg Gly Arg Ala Gly Pro Ser Pro His Phe Leu Gln Gln Pro Glu Asp 
            20                  25                  30          


Leu Val Val Leu Leu Gly Glu Glu Ala Arg Leu Pro Cys Ala Leu Gly 
        35                  40                  45              


Ala Tyr Trp Gly Leu Val Gln Trp Thr Lys Ser Gly Leu Ala Leu Gly 
    50                  55                  60                  


Gly Gln Arg Asp Leu Pro Gly Trp Ser Arg Tyr Trp Ile Ser Gly Asn 
65                  70                  75                  80  


Ala Ala Asn Gly Gln His Asp Leu His Ile Arg Pro Val Glu Leu Glu 
                85                  90                  95      


Asp Glu Ala Ser Tyr Glu Cys Gln Ala Thr Gln Ala Gly Leu Arg Ser 
            100                 105                 110         


Arg Pro Ala Gln Leu His Val Leu Val Pro Pro Glu Ala Pro Gln Val 
        115                 120                 125             


Leu Gly Gly Pro Ser Val Ser Leu Val Ala Gly Val Pro Ala Asn Leu 
    130                 135                 140                 


Thr Cys Arg Ser Arg Gly Asp Ala Arg Pro Thr Pro Glu Leu Leu Trp 
145                 150                 155                 160 


Phe Arg Asp Gly Val Leu Leu Asp Gly Ala Thr Phe His Gln Thr Leu 
                165                 170                 175     


Leu Lys Glu Gly Thr Pro Gly Ser Val Glu Ser Thr Leu Thr Leu Thr 
            180                 185                 190         


Pro Phe Ser His Asp Asp Gly Ala Thr Phe Val Cys Arg Ala Arg Ser 
        195                 200                 205             


Gln Ala Leu Pro Thr Gly Arg Asp Thr Ala Ile Thr Leu Ser Leu Gln 
    210                 215                 220                 


Tyr Pro Pro Glu Val Thr Leu Ser Ala Ser Pro His Thr Val Gln Glu 
225                 230                 235                 240 


Gly Glu Lys Val Ile Phe Leu Cys Gln Ala Thr Ala Gln Pro Pro Val 
                245                 250                 255     


Thr Gly Tyr Arg Trp Ala Lys Gly Gly Ser Pro Val Leu Gly Ala Arg 
            260                 265                 270         


Gly Pro Arg Leu Glu Val Val Ala Asp Ala Ser Phe Leu Thr Glu Pro 
        275                 280                 285             


Val Ser Cys Glu Val Ser Asn Ala Val Gly Ser Ala Asn Arg Ser Thr 
    290                 295                 300                 


Ala Leu Asp Val Leu Phe Gly Pro Ile Leu Gln Ala Lys Pro Glu Pro 
305                 310                 315                 320 


Val Ser Val Asp Val Gly Glu Asp Ala Ser Phe Ser Cys Ala Trp Arg 
                325                 330                 335     


Gly Asn Pro Leu Pro Arg Val Thr Trp Thr Arg Arg Gly Gly Ala Gln 
            340                 345                 350         


Val Leu Gly Ser Gly Ala Thr Leu Arg Leu Pro Ser Val Gly Pro Glu 
        355                 360                 365             


Asp Ala Gly Asp Tyr Val Cys Arg Ala Glu Ala Gly Leu Ser Gly Leu 
    370                 375                 380                 


Arg Gly Gly Ala Ala Glu Ala Arg Leu Thr Val Asn Ala Pro Pro Val 
385                 390                 395                 400 


Val Thr Ala Leu His Ser Ala Pro Ala Phe Leu Arg Gly Pro Ala Arg 
                405                 410                 415     


Leu Gln Cys Leu Val Phe Ala Ser Pro Ala Pro Asp Ala Val Val Trp 
            420                 425                 430         


Ser Trp Asp Glu Gly Phe Leu Glu Ala Gly Ser Gln Gly Arg Phe Leu 
        435                 440                 445             


Val Glu Thr Phe Pro Ala Pro Glu Ser Arg Gly Gly Leu Gly Pro Gly 
    450                 455                 460                 


Leu Ile Ser Val Leu His Ile Ser Gly Thr Gln Glu Ser Asp Phe Ser 
465                 470                 475                 480 


Arg Ser Phe Asn Cys Ser Ala Arg Asn Arg Leu Gly Glu Gly Gly Ala 
                485                 490                 495     


Gln Ala Ser Leu Gly Arg Arg Asp Leu Leu Pro Thr Val Arg Ile Val 
            500                 505                 510         


Ala Gly Val Ala Ala Ala Thr Thr Thr Leu Leu Met Val Ile Thr Gly 
        515                 520                 525             


Val Ala Leu Cys Cys Trp Arg His Ser Lys Ala Ser Ala Ser Phe Ser 
    530                 535                 540                 


Glu Gln Lys Asn Leu Met Arg Ile Pro Gly Ser Ser Asp Gly Ser Ser 
545                 550                 555                 560 


Ser Arg Gly Pro Glu Glu Glu Glu Thr Gly Ser Arg Glu Asp Arg Gly 
                565                 570                 575     


Pro Ile Val His Thr Asp His Ser Asp Leu Val Leu Glu Glu Glu Gly 
            580                 585                 590         


Thr Leu Glu Thr Lys Asp Pro Thr Asn Gly Tyr Tyr Lys Val Arg Gly 
        595                 600                 605             


Val Ser Pro Pro Ala Ser Pro Asp Ser Arg Val Thr Ser Phe Gln Trp 
    610                 615                 620                 


Lys Ser Pro Gly Ile Ser Asn Leu Pro 
625                 630             


<210>  5919
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIRREL3__Homo_sapiens__NP_001155179

<400>  5919

Met Lys Pro Phe Gln Leu Asp Leu Leu Phe Val Cys Phe Phe Leu Phe 
1               5                   10                  15      


Ser Gln Glu Leu Gly Leu Gln Lys Arg Gly Cys Cys Leu Val Leu Gly 
            20                  25                  30          


Tyr Met Ala Lys Asp Lys Phe Arg Arg Met Asn Glu Gly Gln Val Tyr 
        35                  40                  45              


Ser Phe Ser Gln Gln Pro Gln Asp Gln Val Val Val Ser Gly Gln Pro 
    50                  55                  60                  


Val Thr Leu Leu Cys Ala Ile Pro Glu Tyr Asp Gly Phe Val Leu Trp 
65                  70                  75                  80  


Ile Lys Asp Gly Leu Ala Leu Gly Val Gly Arg Asp Leu Ser Ser Tyr 
                85                  90                  95      


Pro Gln Tyr Leu Val Val Gly Asn His Leu Ser Gly Glu His His Leu 
            100                 105                 110         


Lys Ile Leu Arg Ala Glu Leu Gln Asp Asp Ala Val Tyr Glu Cys Gln 
        115                 120                 125             


Ala Ile Gln Ala Ala Ile Arg Ser Arg Pro Ala Arg Leu Thr Val Leu 
    130                 135                 140                 


Val Pro Pro Asp Asp Pro Val Ile Leu Gly Gly Pro Val Ile Ser Leu 
145                 150                 155                 160 


Arg Ala Gly Asp Pro Leu Asn Leu Thr Cys His Ala Asp Asn Ala Lys 
                165                 170                 175     


Pro Ala Ala Ser Ile Ile Trp Leu Arg Lys Gly Glu Val Ile Asn Gly 
            180                 185                 190         


Ala Thr Tyr Ser Lys Thr Leu Leu Arg Asp Gly Lys Arg Glu Ser Ile 
        195                 200                 205             


Val Ser Thr Leu Phe Ile Ser Pro Gly Asp Val Glu Asn Gly Gln Ser 
    210                 215                 220                 


Ile Val Cys Arg Ala Thr Asn Lys Ala Ile Pro Gly Gly Lys Glu Thr 
225                 230                 235                 240 


Ser Val Thr Ile Asp Ile Gln His Pro Pro Leu Val Asn Leu Ser Val 
                245                 250                 255     


Glu Pro Gln Pro Val Leu Glu Asp Asn Val Val Thr Phe His Cys Ser 
            260                 265                 270         


Ala Lys Ala Asn Pro Ala Val Thr Gln Tyr Arg Trp Ala Lys Arg Gly 
        275                 280                 285             


Gln Ile Ile Lys Glu Ala Ser Gly Glu Val Tyr Arg Thr Thr Val Asp 
    290                 295                 300                 


Tyr Thr Tyr Phe Ser Glu Pro Val Ser Cys Glu Val Thr Asn Ala Leu 
305                 310                 315                 320 


Gly Ser Thr Asn Leu Ser Arg Thr Val Asp Val Tyr Phe Gly Pro Arg 
                325                 330                 335     


Met Thr Thr Glu Pro Gln Ser Leu Leu Val Asp Leu Gly Ser Asp Ala 
            340                 345                 350         


Ile Phe Ser Cys Ala Trp Thr Gly Asn Pro Ser Leu Thr Ile Val Trp 
        355                 360                 365             


Met Lys Arg Gly Ser Gly Val Val Leu Ser Asn Glu Lys Thr Leu Thr 
    370                 375                 380                 


Leu Lys Ser Val Arg Gln Glu Asp Ala Gly Lys Tyr Val Cys Arg Ala 
385                 390                 395                 400 


Val Val Pro Arg Val Gly Ala Gly Glu Arg Glu Val Thr Leu Thr Val 
                405                 410                 415     


Asn Gly Pro Pro Ile Ile Ser Ser Thr Gln Thr Gln His Ala Leu His 
            420                 425                 430         


Gly Glu Lys Gly Gln Ile Lys Cys Phe Ile Arg Ser Thr Pro Pro Pro 
        435                 440                 445             


Asp Arg Ile Ala Trp Ser Trp Lys Glu Asn Val Leu Glu Ser Gly Thr 
    450                 455                 460                 


Ser Gly Arg Tyr Thr Val Glu Thr Ile Ser Thr Glu Glu Gly Val Ile 
465                 470                 475                 480 


Ser Thr Leu Thr Ile Ser Asn Ile Val Arg Ala Asp Phe Gln Thr Ile 
                485                 490                 495     


Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Ser Asp Thr Glu Ile Ile 
            500                 505                 510         


Arg Leu Lys Glu Gln Gly Ser Glu Met Lys Ser Gly Ala Gly Leu Glu 
        515                 520                 525             


Ala Glu Ser Val Pro Met Ala Val Ile Ile Gly Val Ala Val Gly Ala 
    530                 535                 540                 


Gly Val Ala Phe Leu Val Leu Met Ala Thr Ile Val Ala Phe Cys Cys 
545                 550                 555                 560 


Ala Arg Ser Gln Arg Ser Thr Gly Gly Arg Ser Gly Ile Ser Gly Arg 
                565                 570                 575     


Gly Thr Glu Lys Lys Ala Arg Leu Arg Leu Pro Arg Arg Ala Ser Lys 
            580                 585                 590         


Gln Glu Cys Asn Glu Gln Gly Ser 
        595                 600 


<210>  5920
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIRREL__Homo_sapiens__NP_001273278

<400>  5920

Met Leu Ser Leu Leu Val Trp Ile Leu Thr Leu Ser Asp Thr Phe Ser 
1               5                   10                  15      


Gln Val Pro Pro Glu Asp Thr Arg Ile Asp Gly Gly Pro Val Ile Leu 
            20                  25                  30          


Leu Gln Ala Gly Thr Pro His Asn Leu Thr Cys Arg Ala Phe Asn Ala 
        35                  40                  45              


Lys Pro Ala Ala Thr Ile Ile Trp Phe Arg Asp Gly Thr Gln Gln Glu 
    50                  55                  60                  


Gly Ala Val Ala Ser Thr Glu Leu Leu Lys Asp Gly Lys Arg Glu Thr 
65                  70                  75                  80  


Thr Val Ser Gln Leu Leu Ile Asn Pro Thr Asp Leu Asp Ile Gly Arg 
                85                  90                  95      


Val Phe Thr Cys Arg Ser Met Asn Glu Ala Ile Pro Ser Gly Lys Glu 
            100                 105                 110         


Thr Ser Ile Glu Leu Asp Val His His Pro Pro Thr Val Thr Leu Ser 
        115                 120                 125             


Ile Glu Pro Gln Thr Val Gln Glu Gly Glu Arg Val Val Phe Thr Cys 
    130                 135                 140                 


Gln Ala Thr Ala Asn Pro Glu Ile Leu Gly Tyr Arg Trp Ala Lys Gly 
145                 150                 155                 160 


Gly Phe Leu Ile Glu Asp Ala His Glu Ser Arg Tyr Glu Thr Asn Val 
                165                 170                 175     


Asp Tyr Ser Phe Phe Thr Glu Pro Val Ser Cys Glu Val His Asn Lys 
            180                 185                 190         


Val Gly Ser Thr Asn Val Ser Thr Leu Val Asn Val His Phe Ala Pro 
        195                 200                 205             


Arg Ile Val Val Asp Pro Lys Pro Thr Thr Thr Asp Ile Gly Ser Asp 
    210                 215                 220                 


Val Thr Leu Thr Cys Val Trp Val Gly Asn Pro Pro Leu Thr Leu Thr 
225                 230                 235                 240 


Trp Thr Lys Lys Asp Ser Asn Met Val Leu Ser Asn Ser Asn Gln Leu 
                245                 250                 255     


Leu Leu Lys Ser Val Thr Gln Ala Asp Ala Gly Thr Tyr Thr Cys Arg 
            260                 265                 270         


Ala Ile Val Pro Arg Ile Gly Val Ala Glu Arg Glu Val Pro Leu Tyr 
        275                 280                 285             


Val Asn Gly Pro Pro Ile Ile Ser Ser Glu Ala Val Gln Tyr Ala Val 
    290                 295                 300                 


Arg Gly Asp Gly Gly Lys Val Glu Cys Phe Ile Gly Ser Thr Pro Pro 
305                 310                 315                 320 


Pro Asp Arg Ile Ala Trp Ala Trp Lys Glu Asn Phe Leu Glu Val Gly 
                325                 330                 335     


Thr Leu Glu Arg Tyr Thr Val Glu Arg Thr Asn Ser Gly Ser Gly Val 
            340                 345                 350         


Leu Ser Thr Leu Thr Ile Asn Asn Val Met Glu Ala Asp Phe Gln Thr 
        355                 360                 365             


His Tyr Asn Cys Thr Ala Trp Asn Ser Phe Gly Pro Gly Thr Ala Ile 
    370                 375                 380                 


Ile Gln Leu Glu Glu Arg Glu Val Leu Pro Val Gly Ile Ile Ala Gly 
385                 390                 395                 400 


Ala Thr Ile Gly Ala Ser Ile Leu Leu Ile Phe Phe Phe Ile Ala Leu 
                405                 410                 415     


Val Phe Phe Leu Tyr Arg Arg Arg Lys Gly Ser Arg Lys Asp Val Thr 
            420                 425                 430         


Leu Arg Lys Leu Asp Ile Lys Val Glu Thr Val Asn Arg Glu Pro Leu 
        435                 440                 445             


Thr Met His Ser Asp Arg Glu Asp Asp Thr Ala Ser Val Ser Thr Ala 
    450                 455                 460                 


Thr Arg Val Met Lys Ala Ile Tyr Ser Ser Phe Lys Asp Asp Val Asp 
465                 470                 475                 480 


Leu Lys Gln Asp Leu Arg Cys Asp Thr Ile Asp Thr Arg Glu Glu Tyr 
                485                 490                 495     


Glu Met Lys Asp Pro Thr Asn Gly Tyr Tyr Asn Val Arg Ala His Glu 
            500                 505                 510         


Asp Arg Pro Ser Ser Arg Ala Val Leu Tyr Ala Asp Tyr Arg Ala Pro 
        515                 520                 525             


Gly Pro Ala Arg Phe Asp Gly Arg Pro Ser Ser Arg Leu Ser His Ser 
    530                 535                 540                 


Ser Gly Tyr Ala Gln Leu Asn Thr Tyr Ser Arg Gly Pro Ala Ser Asp 
545                 550                 555                 560 


Tyr Gly Pro Glu Pro Thr Pro Pro Gly Pro Ala Ala Pro Ala Gly Thr 
                565                 570                 575     


Asp Thr Thr Ser Gln Leu Ser Tyr Glu Asn Tyr Glu Lys Phe Asn Ser 
            580                 585                 590         


His Pro Phe Pro Gly Ala Ala Gly Tyr Pro Thr Tyr Arg Leu Gly Tyr 
        595                 600                 605             


Pro Gln Ala Pro Pro Ser Gly Leu Glu Arg Thr Pro Tyr Glu Ala Tyr 
    610                 615                 620                 


Asp Pro Ile Gly Lys Tyr Ala Thr Ala Thr Arg Phe Ser Tyr Thr Ser 
625                 630                 635                 640 


Gln His Ser Asp Tyr Gly Gln Arg Phe Gln Gln Arg Met Gln Thr His 
                645                 650                 655     


Val 
    


<210>  5921
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KISS1__Homo_sapiens__XP_011507827

<400>  5921

Met Asn Ser Leu Val Ser Trp Gln Leu Leu Leu Phe Leu Cys Ala Thr 
1               5                   10                  15      


His Phe Gly Glu Pro Leu Glu Lys Val Ala Ser Val Gly Asn Ser Arg 
            20                  25                  30          


Pro Thr Gly Gln Gln Leu Glu Ser Leu Gly Leu Leu Ala Pro Gly Glu 
        35                  40                  45              


Gln Ser Leu Pro Cys Thr Glu Arg Lys Pro Ala Ala Thr Ala Arg Leu 
    50                  55                  60                  


Ser Arg Arg Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser Gly Ser 
65                  70                  75                  80  


Pro Gln Gln Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile Pro Ala 
                85                  90                  95      


Pro Gln Gly Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro Asn Tyr 
            100                 105                 110         


Asn Trp Asn Ser Phe Gly Leu Arg Phe Gly Lys Arg Glu Ala Ala Pro 
        115                 120                 125             


Gly Asn His Gly Arg Ser Ala Gly Arg Gly 
    130                 135             


<210>  5922
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KISS1R__Homo_sapiens__NP_115940

<400>  5922

Met His Thr Val Ala Thr Ser Gly Pro Asn Ala Ser Trp Gly Ala Pro 
1               5                   10                  15      


Ala Asn Ala Ser Gly Cys Pro Gly Cys Gly Ala Asn Ala Ser Asp Gly 
            20                  25                  30          


Pro Val Pro Ser Pro Arg Ala Val Asp Ala Trp Leu Val Pro Leu Phe 
        35                  40                  45              


Phe Ala Ala Leu Met Leu Leu Gly Leu Val Gly Asn Ser Leu Val Ile 
    50                  55                  60                  


Tyr Val Ile Cys Arg His Lys Pro Met Arg Thr Val Thr Asn Phe Tyr 
65                  70                  75                  80  


Ile Ala Asn Leu Ala Ala Thr Asp Val Thr Phe Leu Leu Cys Cys Val 
                85                  90                  95      


Pro Phe Thr Ala Leu Leu Tyr Pro Leu Pro Gly Trp Val Leu Gly Asp 
            100                 105                 110         


Phe Met Cys Lys Phe Val Asn Tyr Ile Gln Gln Val Ser Val Gln Ala 
        115                 120                 125             


Thr Cys Ala Thr Leu Thr Ala Met Ser Val Asp Arg Trp Tyr Val Thr 
    130                 135                 140                 


Val Phe Pro Leu Arg Ala Leu His Arg Arg Thr Pro Arg Leu Ala Leu 
145                 150                 155                 160 


Ala Val Ser Leu Ser Ile Trp Val Gly Ser Ala Ala Val Ser Ala Pro 
                165                 170                 175     


Val Leu Ala Leu His Arg Leu Ser Pro Gly Pro Arg Ala Tyr Cys Ser 
            180                 185                 190         


Glu Ala Phe Pro Ser Arg Ala Leu Glu Arg Ala Phe Ala Leu Tyr Asn 
        195                 200                 205             


Leu Leu Ala Leu Tyr Leu Leu Pro Leu Leu Ala Thr Cys Ala Cys Tyr 
    210                 215                 220                 


Ala Ala Met Leu Arg His Leu Gly Arg Val Ala Val Arg Pro Ala Pro 
225                 230                 235                 240 


Ala Asp Ser Ala Leu Gln Gly Gln Val Leu Ala Glu Arg Ala Gly Ala 
                245                 250                 255     


Val Arg Ala Lys Val Ser Arg Leu Val Ala Ala Val Val Leu Leu Phe 
            260                 265                 270         


Ala Ala Cys Trp Gly Pro Ile Gln Leu Phe Leu Val Leu Gln Ala Leu 
        275                 280                 285             


Gly Pro Ala Gly Ser Trp His Pro Arg Ser Tyr Ala Ala Tyr Ala Leu 
    290                 295                 300                 


Lys Thr Trp Ala His Cys Met Ser Tyr Ser Asn Ser Ala Leu Asn Pro 
305                 310                 315                 320 


Leu Leu Tyr Ala Phe Leu Gly Ser His Phe Arg Gln Ala Phe Arg Arg 
                325                 330                 335     


Val Cys Pro Cys Ala Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Gly 
            340                 345                 350         


Pro Ser Asp Pro Ala Ala Pro His Ala Glu Leu Leu Arg Leu Gly Ser 
        355                 360                 365             


His Pro Ala Pro Ala Arg Ala Gln Lys Pro Gly Ser Ser Gly Leu Ala 
    370                 375                 380                 


Ala Arg Gly Leu Cys Val Leu Gly Glu Asp Asn Ala Pro Leu 
385                 390                 395             


<210>  5923
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIT__Homo_sapiens__NP_000213

<400>  5923

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  5924
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KITLG__Homo_sapiens__NP_000890

<400>  5924

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  5925
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLB__Homo_sapiens__NP_783864

<400>  5925

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  5926
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLC1__Homo_sapiens__NP_001123579

<400>  5926

Met Tyr Asp Asn Met Ser Thr Met Val Tyr Ile Lys Glu Asp Lys Leu 
1               5                   10                  15      


Glu Lys Leu Thr Gln Asp Glu Ile Ile Ser Lys Thr Lys Gln Val Ile 
            20                  25                  30          


Gln Gly Leu Glu Ala Leu Lys Asn Glu His Asn Ser Ile Leu Gln Ser 
        35                  40                  45              


Leu Leu Glu Thr Leu Lys Cys Leu Lys Lys Asp Asp Glu Ser Asn Leu 
    50                  55                  60                  


Val Glu Glu Lys Ser Asn Met Ile Arg Lys Ser Leu Glu Met Leu Glu 
65                  70                  75                  80  


Leu Gly Leu Ser Glu Ala Gln Val Met Met Ala Leu Ser Asn His Leu 
                85                  90                  95      


Asn Ala Val Glu Ser Glu Lys Gln Lys Leu Arg Ala Gln Val Arg Arg 
            100                 105                 110         


Leu Cys Gln Glu Asn Gln Trp Leu Arg Asp Glu Leu Ala Asn Thr Gln 
        115                 120                 125             


Gln Lys Leu Gln Lys Ser Glu Gln Ser Val Ala Gln Leu Glu Glu Glu 
    130                 135                 140                 


Lys Lys His Leu Glu Phe Met Asn Gln Leu Lys Lys Tyr Asp Asp Asp 
145                 150                 155                 160 


Ile Ser Pro Ser Glu Asp Lys Asp Thr Asp Ser Thr Lys Glu Pro Leu 
                165                 170                 175     


Asp Asp Leu Phe Pro Asn Asp Glu Asp Asp Pro Gly Gln Gly Ile Gln 
            180                 185                 190         


Gln Gln His Ser Ser Ala Ala Ala Ala Ala Gln Gln Gly Gly Tyr Glu 
        195                 200                 205             


Ile Pro Ala Arg Leu Arg Thr Leu His Asn Leu Val Ile Gln Tyr Ala 
    210                 215                 220                 


Ser Gln Gly Arg Tyr Glu Val Ala Val Pro Leu Cys Lys Gln Ala Leu 
225                 230                 235                 240 


Glu Asp Leu Glu Lys Thr Ser Gly His Asp His Pro Asp Val Ala Thr 
                245                 250                 255     


Met Leu Asn Ile Leu Ala Leu Val Tyr Arg Asp Gln Asn Lys Tyr Lys 
            260                 265                 270         


Asp Ala Ala Asn Leu Leu Asn Asp Ala Leu Ala Ile Arg Glu Lys Thr 
        275                 280                 285             


Leu Gly Lys Asp His Pro Ala Val Ala Ala Thr Leu Asn Asn Leu Ala 
    290                 295                 300                 


Val Leu Tyr Gly Lys Arg Gly Lys Tyr Lys Glu Ala Glu Pro Leu Cys 
305                 310                 315                 320 


Lys Arg Ala Leu Glu Ile Arg Glu Lys Val Leu Gly Lys Asp His Pro 
                325                 330                 335     


Asp Val Ala Lys Gln Leu Asn Asn Leu Ala Leu Leu Cys Gln Asn Gln 
            340                 345                 350         


Gly Lys Tyr Glu Glu Val Glu Tyr Tyr Tyr Gln Arg Ala Leu Glu Ile 
        355                 360                 365             


Tyr Gln Thr Lys Leu Gly Pro Asp Asp Pro Asn Val Ala Lys Thr Lys 
    370                 375                 380                 


Asn Asn Leu Ala Ser Cys Tyr Leu Lys Gln Gly Lys Phe Lys Gln Ala 
385                 390                 395                 400 


Glu Thr Leu Tyr Lys Glu Ile Leu Thr Arg Ala His Glu Arg Glu Phe 
                405                 410                 415     


Gly Ser Val Asp Asp Glu Asn Lys Pro Ile Trp Met His Ala Glu Glu 
            420                 425                 430         


Arg Glu Glu Cys Lys Gly Lys Gln Lys Asp Gly Thr Ser Phe Gly Glu 
        435                 440                 445             


Tyr Gly Gly Trp Tyr Lys Ala Cys Lys Val Asp Ser Pro Thr Val Thr 
    450                 455                 460                 


Thr Thr Leu Lys Asn Leu Gly Ala Leu Tyr Arg Arg Gln Gly Lys Phe 
465                 470                 475                 480 


Glu Ala Ala Glu Thr Leu Glu Glu Ala Ala Met Arg Ser Arg Lys Gln 
                485                 490                 495     


Gly Leu Asp Asn Val His Lys Gln Arg Val Ala Glu Val Leu Asn Asp 
            500                 505                 510         


Pro Glu Asn Met Glu Lys Arg Arg Ser Arg Glu Ser Leu Asn Val Asp 
        515                 520                 525             


Val Val Lys Tyr Glu Ser Gly Pro Asp Gly Gly Glu Glu Val Ser Met 
    530                 535                 540                 


Ser Val Glu Trp Asn Gly Asp Gly Thr Gly Ser Leu Lys Arg Ser Gly 
545                 550                 555                 560 


Ser Phe Ser Lys Leu Arg Ala Ser Ile Arg Arg Ser Ser Glu Lys Leu 
                565                 570                 575     


Val Arg Lys Leu Lys Gly Gly Ser Ser Arg Glu Ser Glu Pro Lys Asn 
            580                 585                 590         


Pro Gly Ala Ser Leu Ala Glu Pro Leu Phe Val Glu Asn Asp Ser Ser 
        595                 600                 605             


Ser Ser Gly Leu Glu Asp Ala Thr Ala Asn 
    610                 615             


<210>  5927
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF10__Homo_sapiens__NP_001027453

<400>  5927

Met Glu Glu Arg Met Glu Met Ile Ser Glu Arg Pro Lys Glu Ser Met 
1               5                   10                  15      


Tyr Ser Trp Asn Lys Thr Ala Glu Lys Ser Asp Phe Glu Ala Val Glu 
            20                  25                  30          


Ala Leu Met Ser Met Ser Cys Ser Trp Lys Ser Asp Phe Lys Lys Tyr 
        35                  40                  45              


Val Glu Asn Arg Pro Val Thr Pro Val Ser Asp Leu Ser Glu Glu Glu 
    50                  55                  60                  


Asn Leu Leu Pro Gly Thr Pro Asp Phe His Thr Ile Pro Ala Phe Cys 
65                  70                  75                  80  


Leu Thr Pro Pro Tyr Ser Pro Ser Asp Phe Glu Pro Ser Gln Val Ser 
                85                  90                  95      


Asn Leu Met Ala Pro Ala Pro Ser Thr Val His Phe Lys Ser Leu Ser 
            100                 105                 110         


Asp Thr Ala Lys Pro His Ile Ala Ala Pro Phe Lys Glu Glu Glu Lys 
        115                 120                 125             


Ser Pro Val Ser Ala Pro Lys Leu Pro Lys Ala Gln Ala Thr Ser Val 
    130                 135                 140                 


Ile Arg His Thr Ala Asp Ala Gln Leu Cys Asn His Gln Thr Cys Pro 
145                 150                 155                 160 


Met Lys Ala Ala Ser Ile Leu Asn Tyr Gln Asn Asn Ser Phe Arg Arg 
                165                 170                 175     


Arg Thr His Leu Asn Val Glu Ala Ala Arg Lys Asn Ile Pro Cys Ala 
            180                 185                 190         


Ala Val Ser Pro Asn Arg Ser Lys Cys Glu Arg Asn Thr Val Ala Asp 
        195                 200                 205             


Val Asp Glu Lys Ala Ser Ala Ala Leu Tyr Asp Phe Ser Val Pro Ser 
    210                 215                 220                 


Ser Glu Thr Val Ile Cys Arg Ser Gln Pro Ala Pro Val Ser Pro Gln 
225                 230                 235                 240 


Gln Lys Ser Val Leu Val Ser Pro Pro Ala Val Ser Ala Gly Gly Val 
                245                 250                 255     


Pro Pro Met Pro Val Ile Cys Gln Met Val Pro Leu Pro Ala Asn Asn 
            260                 265                 270         


Pro Val Val Thr Thr Val Val Pro Ser Thr Pro Pro Ser Gln Pro Pro 
        275                 280                 285             


Ala Val Cys Pro Pro Val Val Phe Met Gly Thr Gln Val Pro Lys Gly 
    290                 295                 300                 


Ala Val Met Phe Val Val Pro Gln Pro Val Val Gln Ser Ser Lys Pro 
305                 310                 315                 320 


Pro Val Val Ser Pro Asn Gly Thr Arg Leu Ser Pro Ile Ala Pro Ala 
                325                 330                 335     


Pro Gly Phe Ser Pro Ser Ala Ala Lys Val Thr Pro Gln Ile Asp Ser 
            340                 345                 350         


Ser Arg Ile Arg Ser His Ile Cys Ser His Pro Gly Cys Gly Lys Thr 
        355                 360                 365             


Tyr Phe Lys Ser Ser His Leu Lys Ala His Thr Arg Thr His Thr Gly 
    370                 375                 380                 


Glu Lys Pro Phe Ser Cys Ser Trp Lys Gly Cys Glu Arg Arg Phe Ala 
385                 390                 395                 400 


Arg Ser Asp Glu Leu Ser Arg His Arg Arg Thr His Thr Gly Glu Lys 
                405                 410                 415     


Lys Phe Ala Cys Pro Met Cys Asp Arg Arg Phe Met Arg Ser Asp His 
            420                 425                 430         


Leu Thr Lys His Ala Arg Arg His Leu Ser Ala Lys Lys Leu Pro Asn 
        435                 440                 445             


Trp Gln Met Glu Val Ser Lys Leu Asn Asp Ile Ala Leu Pro Pro Thr 
    450                 455                 460                 


Pro Ala Pro Thr Gln 
465                 


<210>  5928
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF11__Homo_sapiens__NP_003588

<400>  5928

Met His Thr Pro Asp Phe Ala Gly Pro Asp Asp Ala Arg Ala Val Asp 
1               5                   10                  15      


Ile Met Asp Ile Cys Glu Ser Ile Leu Glu Arg Lys Arg His Asp Ser 
            20                  25                  30          


Glu Arg Ser Thr Cys Ser Ile Leu Glu Gln Thr Asp Met Glu Ala Val 
        35                  40                  45              


Glu Ala Leu Val Cys Met Ser Ser Trp Gly Gln Arg Ser Gln Lys Gly 
    50                  55                  60                  


Asp Leu Leu Arg Ile Arg Pro Leu Thr Pro Val Ser Asp Ser Gly Asp 
65                  70                  75                  80  


Val Thr Thr Thr Val His Met Asp Ala Ala Thr Pro Glu Leu Pro Lys 
                85                  90                  95      


Asp Phe His Ser Leu Ser Thr Leu Cys Ile Thr Pro Pro Gln Ser Pro 
            100                 105                 110         


Asp Leu Val Glu Pro Ser Thr Arg Thr Pro Val Ser Pro Gln Val Thr 
        115                 120                 125             


Asp Ser Lys Ala Cys Thr Ala Thr Asp Val Leu Gln Ser Ser Ala Val 
    130                 135                 140                 


Val Ala Arg Ala Leu Ser Gly Gly Ala Glu Arg Gly Leu Leu Gly Leu 
145                 150                 155                 160 


Glu Pro Val Pro Ser Ser Pro Cys Arg Ala Lys Gly Thr Ser Val Ile 
                165                 170                 175     


Arg His Thr Gly Glu Ser Pro Ala Ala Cys Phe Pro Thr Ile Gln Thr 
            180                 185                 190         


Pro Asp Cys Arg Leu Ser Asp Ser Arg Glu Gly Glu Glu Gln Leu Leu 
        195                 200                 205             


Gly His Phe Glu Thr Leu Gln Asp Thr His Leu Thr Asp Ser Leu Leu 
    210                 215                 220                 


Ser Thr Asn Leu Val Ser Cys Gln Pro Cys Leu His Lys Ser Gly Gly 
225                 230                 235                 240 


Leu Leu Leu Thr Asp Lys Gly Gln Gln Ala Gly Trp Pro Gly Ala Val 
                245                 250                 255     


Gln Thr Cys Ser Pro Lys Asn Tyr Glu Asn Asp Leu Pro Arg Lys Thr 
            260                 265                 270         


Thr Pro Leu Ile Ser Val Ser Val Pro Ala Pro Pro Val Leu Cys Gln 
        275                 280                 285             


Met Ile Pro Val Thr Gly Gln Ser Ser Met Leu Pro Ala Phe Leu Lys 
    290                 295                 300                 


Pro Pro Pro Gln Leu Ser Val Gly Thr Val Arg Pro Ile Leu Ala Gln 
305                 310                 315                 320 


Ala Ala Pro Ala Pro Gln Pro Val Phe Val Gly Pro Ala Val Pro Gln 
                325                 330                 335     


Gly Ala Val Met Leu Val Leu Pro Gln Gly Ala Leu Pro Pro Pro Ala 
            340                 345                 350         


Pro Cys Ala Ala Asn Val Met Ala Ala Gly Asn Thr Lys Leu Leu Pro 
        355                 360                 365             


Leu Ala Pro Ala Pro Val Phe Ile Thr Ser Ser Gln Asn Cys Val Pro 
    370                 375                 380                 


Gln Val Asp Phe Ser Arg Arg Arg Asn Tyr Val Cys Ser Phe Pro Gly 
385                 390                 395                 400 


Cys Arg Lys Thr Tyr Phe Lys Ser Ser His Leu Lys Ala His Leu Arg 
                405                 410                 415     


Thr His Thr Gly Glu Lys Pro Phe Asn Cys Ser Trp Asp Gly Cys Asp 
            420                 425                 430         


Lys Lys Phe Ala Arg Ser Asp Glu Leu Ser Arg His Arg Arg Thr His 
        435                 440                 445             


Thr Gly Glu Lys Lys Phe Val Cys Pro Val Cys Asp Arg Arg Phe Met 
    450                 455                 460                 


Arg Ser Asp His Leu Thr Lys His Ala Arg Arg His Met Thr Thr Lys 
465                 470                 475                 480 


Lys Ile Pro Gly Trp Gln Ala Glu Val Gly Lys Leu Asn Arg Ile Ala 
                485                 490                 495     


Ser Ala Glu Ser Pro Gly Ser Pro Leu Val Ser Met Pro Ala Ser Ala 
            500                 505                 510         


<210>  5929
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF12__Homo_sapiens__XP_011533211

<400>  5929

Met Asn Ile His Met Lys Arg Lys Thr Ile Lys Asn Ile Asn Thr Phe 
1               5                   10                  15      


Glu Asn Arg Met Leu Met Leu Asp Gly Met Pro Ala Val Arg Val Lys 
            20                  25                  30          


Thr Glu Leu Leu Glu Ser Glu Gln Gly Ser Pro Asn Val His Asn Tyr 
        35                  40                  45              


Pro Asp Met Glu Ala Val Pro Leu Leu Leu Asn Asn Val Lys Gly Glu 
    50                  55                  60                  


Pro Pro Glu Asp Ser Leu Ser Val Asp His Phe Gln Thr Gln Thr Glu 
65                  70                  75                  80  


Pro Val Asp Leu Ser Ile Asn Lys Ala Arg Thr Ser Pro Thr Ala Val 
                85                  90                  95      


Ser Ser Ser Pro Val Ser Met Thr Ala Ser Ala Ser Ser Pro Ser Ser 
            100                 105                 110         


Thr Ser Thr Ser Ser Ser Ser Ser Ser Arg Leu Ala Ser Ser Pro Thr 
        115                 120                 125             


Val Ile Thr Ser Val Ser Ser Ala Ser Ser Ser Ser Thr Val Leu Thr 
    130                 135                 140                 


Pro Gly Pro Leu Val Ala Ser Ala Ser Gly Val Gly Gly Gln Gln Phe 
145                 150                 155                 160 


Leu His Ile Ile His Pro Val Pro Pro Ser Ser Pro Met Asn Leu Gln 
                165                 170                 175     


Ser Asn Lys Leu Ser His Val His Arg Ile Pro Val Val Val Gln Ser 
            180                 185                 190         


Val Pro Val Val Tyr Thr Ala Val Arg Ser Pro Gly Asn Val Asn Asn 
        195                 200                 205             


Thr Ile Val Val Pro Leu Leu Glu Asp Gly Arg Gly His Gly Lys Ala 
    210                 215                 220                 


Gln Met Asp Pro Arg Gly Leu Ser Pro Arg Gln Ser Lys Ser Asp Ser 
225                 230                 235                 240 


Asp Asp Asp Asp Leu Pro Asn Val Thr Leu Asp Ser Val Asn Glu Thr 
                245                 250                 255     


Gly Ser Thr Ala Leu Ser Ile Ala Arg Ala Val Gln Glu Val His Pro 
            260                 265                 270         


Ser Pro Val Ser Arg Val Arg Gly Asn Arg Met Asn Asn Gln Lys Phe 
        275                 280                 285             


Pro Cys Ser Ile Ser Pro Phe Ser Ile Glu Ser Thr Arg Arg Gln Arg 
    290                 295                 300                 


Arg Ser Glu Ser Pro Asp Ser Arg Lys Arg Arg Ile His Arg Cys Asp 
305                 310                 315                 320 


Phe Glu Gly Cys Asn Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala 
                325                 330                 335     


His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu 
            340                 345                 350         


Gly Cys Thr Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr 
        355                 360                 365             


Arg Lys His Thr Gly Val Lys Pro Phe Lys Cys Ala Asp Cys Asp Arg 
    370                 375                 380                 


Ser Phe Ser Arg Ser Asp His Leu Ala Leu His Arg Arg Arg His Met 
385                 390                 395                 400 


Leu Val 
        


<210>  5930
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF13__Homo_sapiens__NP_057079

<400>  5930

Met Ala Ala Ala Ala Tyr Val Asp His Phe Ala Ala Glu Cys Leu Val 
1               5                   10                  15      


Ser Met Ser Ser Arg Ala Val Val His Gly Pro Arg Glu Gly Pro Glu 
            20                  25                  30          


Ser Arg Pro Glu Gly Ala Ala Val Ala Ala Thr Pro Thr Leu Pro Arg 
        35                  40                  45              


Val Glu Glu Arg Arg Asp Gly Lys Asp Ser Ala Ser Leu Phe Val Val 
    50                  55                  60                  


Ala Arg Ile Leu Ala Asp Leu Asn Gln Gln Ala Pro Ala Pro Ala Pro 
65                  70                  75                  80  


Ala Glu Arg Arg Glu Gly Ala Ala Ala Arg Lys Ala Arg Thr Pro Cys 
                85                  90                  95      


Arg Leu Pro Pro Pro Ala Pro Glu Pro Thr Ser Pro Gly Ala Glu Gly 
            100                 105                 110         


Ala Ala Ala Ala Pro Pro Ser Pro Ala Trp Ser Glu Pro Glu Pro Glu 
        115                 120                 125             


Ala Gly Leu Glu Pro Glu Arg Glu Pro Gly Pro Ala Gly Ser Gly Glu 
    130                 135                 140                 


Pro Gly Leu Arg Gln Arg Val Arg Arg Gly Arg Ser Arg Ala Asp Leu 
145                 150                 155                 160 


Glu Ser Pro Gln Arg Lys His Lys Cys His Tyr Ala Gly Cys Glu Lys 
                165                 170                 175     


Val Tyr Gly Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr 
            180                 185                 190         


Gly Glu Arg Pro Phe Ala Cys Ser Trp Gln Asp Cys Asn Lys Lys Phe 
        195                 200                 205             


Ala Arg Ser Asp Glu Leu Ala Arg His Tyr Arg Thr His Thr Gly Glu 
    210                 215                 220                 


Lys Lys Phe Ser Cys Pro Ile Cys Glu Lys Arg Phe Met Arg Ser Asp 
225                 230                 235                 240 


His Leu Thr Lys His Ala Arg Arg His Ala Asn Phe His Pro Gly Met 
                245                 250                 255     


Leu Gln Arg Arg Gly Gly Gly Ser Arg Thr Gly Ser Leu Ser Asp Tyr 
            260                 265                 270         


Ser Arg Ser Asp Ala Ser Ser Pro Thr Ile Ser Pro Ala Ser Ser Pro 
        275                 280                 285             


<210>  5931
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF14__Homo_sapiens__NP_619638

<400>  5931

Met Ser Ala Ala Val Ala Cys Leu Asp Tyr Phe Ala Ala Glu Cys Leu 
1               5                   10                  15      


Val Ser Met Ser Ala Gly Ala Val Val His Arg Arg Pro Pro Asp Pro 
            20                  25                  30          


Glu Gly Ala Gly Gly Ala Ala Gly Ser Glu Val Gly Ala Ala Pro Pro 
        35                  40                  45              


Glu Ser Ala Leu Pro Gly Pro Gly Pro Pro Gly Pro Ala Ser Val Pro 
    50                  55                  60                  


Gln Leu Pro Gln Val Pro Ala Pro Ser Pro Gly Ala Gly Gly Ala Ala 
65                  70                  75                  80  


Pro His Leu Leu Ala Ala Ser Val Trp Ala Asp Leu Arg Gly Ser Ser 
                85                  90                  95      


Gly Glu Gly Ser Trp Glu Asn Ser Gly Glu Ala Pro Arg Ala Ser Ser 
            100                 105                 110         


Gly Phe Ser Asp Pro Ile Pro Cys Ser Val Gln Thr Pro Cys Ser Glu 
        115                 120                 125             


Leu Ala Pro Ala Ser Gly Ala Ala Ala Val Cys Ala Pro Glu Ser Ser 
    130                 135                 140                 


Ser Asp Ala Pro Ala Val Pro Ser Ala Pro Ala Ala Pro Gly Ala Pro 
145                 150                 155                 160 


Ala Ala Ser Gly Gly Phe Ser Gly Gly Ala Leu Gly Ala Gly Pro Ala 
                165                 170                 175     


Pro Ala Ala Asp Gln Ala Pro Arg Arg Arg Ser Val Thr Pro Ala Ala 
            180                 185                 190         


Lys Arg His Gln Cys Pro Phe Pro Gly Cys Thr Lys Ala Tyr Tyr Lys 
        195                 200                 205             


Ser Ser His Leu Lys Ser His Gln Arg Thr His Thr Gly Glu Arg Pro 
    210                 215                 220                 


Phe Ser Cys Asp Trp Leu Asp Cys Asp Lys Lys Phe Thr Arg Ser Asp 
225                 230                 235                 240 


Glu Leu Ala Arg His Tyr Arg Thr His Thr Gly Glu Lys Arg Phe Ser 
                245                 250                 255     


Cys Pro Leu Cys Pro Lys Gln Phe Ser Arg Ser Asp His Leu Thr Lys 
            260                 265                 270         


His Ala Arg Arg His Pro Thr Tyr His Pro Asp Met Ile Glu Tyr Arg 
        275                 280                 285             


Gly Arg Arg Arg Thr Pro Arg Ile Asp Pro Pro Leu Thr Ser Glu Val 
    290                 295                 300                 


Glu Ser Ser Ala Ser Gly Ser Gly Pro Gly Pro Ala Pro Ser Phe Thr 
305                 310                 315                 320 


Thr Cys Leu 
            


<210>  5932
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF15__Homo_sapiens__NP_054798

<400>  5932

Met Val Asp His Leu Leu Pro Val Asp Glu Asn Phe Ser Ser Pro Lys 
1               5                   10                  15      


Cys Pro Val Gly Tyr Leu Gly Asp Arg Leu Val Gly Arg Arg Ala Tyr 
            20                  25                  30          


His Met Leu Pro Ser Pro Val Ser Glu Asp Asp Ser Asp Ala Ser Ser 
        35                  40                  45              


Pro Cys Ser Cys Ser Ser Pro Asp Ser Gln Ala Leu Cys Ser Cys Tyr 
    50                  55                  60                  


Gly Gly Gly Leu Gly Thr Glu Ser Gln Asp Ser Ile Leu Asp Phe Leu 
65                  70                  75                  80  


Leu Ser Gln Ala Thr Leu Gly Ser Gly Gly Gly Ser Gly Ser Ser Ile 
                85                  90                  95      


Gly Ala Ser Ser Gly Pro Val Ala Trp Gly Pro Trp Arg Arg Ala Ala 
            100                 105                 110         


Ala Pro Val Lys Gly Glu His Phe Cys Leu Pro Glu Phe Pro Leu Gly 
        115                 120                 125             


Asp Pro Asp Asp Val Pro Arg Pro Phe Gln Pro Thr Leu Glu Glu Ile 
    130                 135                 140                 


Glu Glu Phe Leu Glu Glu Asn Met Glu Pro Gly Val Lys Glu Val Pro 
145                 150                 155                 160 


Glu Gly Asn Ser Lys Asp Leu Asp Ala Cys Ser Gln Leu Ser Ala Gly 
                165                 170                 175     


Pro His Lys Ser His Leu His Pro Gly Ser Ser Gly Arg Glu Arg Cys 
            180                 185                 190         


Ser Pro Pro Pro Gly Gly Ala Ser Ala Gly Gly Ala Gln Gly Pro Gly 
        195                 200                 205             


Gly Gly Pro Thr Pro Asp Gly Pro Ile Pro Val Leu Leu Gln Ile Gln 
    210                 215                 220                 


Pro Val Pro Val Lys Gln Glu Ser Gly Thr Gly Pro Ala Ser Pro Gly 
225                 230                 235                 240 


Gln Ala Pro Glu Asn Val Lys Val Ala Gln Leu Leu Val Asn Ile Gln 
                245                 250                 255     


Gly Gln Thr Phe Ala Leu Val Pro Gln Val Val Pro Ser Ser Asn Leu 
            260                 265                 270         


Asn Leu Pro Ser Lys Phe Val Arg Ile Ala Pro Val Pro Ile Ala Ala 
        275                 280                 285             


Lys Pro Val Gly Ser Gly Pro Leu Gly Pro Gly Pro Ala Gly Leu Leu 
    290                 295                 300                 


Met Gly Gln Lys Phe Pro Lys Asn Pro Ala Ala Glu Leu Ile Lys Met 
305                 310                 315                 320 


His Lys Cys Thr Phe Pro Gly Cys Ser Lys Met Tyr Thr Lys Ser Ser 
                325                 330                 335     


His Leu Lys Ala His Leu Arg Arg His Thr Gly Glu Lys Pro Phe Ala 
            340                 345                 350         


Cys Thr Trp Pro Gly Cys Gly Trp Arg Phe Ser Arg Ser Asp Glu Leu 
        355                 360                 365             


Ser Arg His Arg Arg Ser His Ser Gly Val Lys Pro Tyr Gln Cys Pro 
    370                 375                 380                 


Val Cys Glu Lys Lys Phe Ala Arg Ser Asp His Leu Ser Lys His Ile 
385                 390                 395                 400 


Lys Val His Arg Phe Pro Arg Ser Ser Arg Ser Val Arg Ser Val Asn 
                405                 410                 415     


<210>  5933
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF16__Homo_sapiens__NP_114124

<400>  5933

Met Ser Ala Ala Val Ala Cys Val Asp Tyr Phe Ala Ala Asp Val Leu 
1               5                   10                  15      


Met Ala Ile Ser Ser Gly Ala Val Val His Arg Gly Arg Pro Gly Pro 
            20                  25                  30          


Glu Gly Ala Gly Pro Ala Ala Gly Leu Asp Val Arg Ala Ala Arg Arg 
        35                  40                  45              


Glu Ala Ala Ser Pro Gly Thr Pro Gly Pro Pro Pro Pro Pro Pro Ala 
    50                  55                  60                  


Ala Ser Gly Pro Gly Pro Gly Ala Ala Ala Ala Pro His Leu Leu Ala 
65                  70                  75                  80  


Ala Ser Ile Leu Ala Asp Leu Arg Gly Gly Pro Gly Ala Ala Pro Gly 
                85                  90                  95      


Gly Ala Ser Pro Ala Ser Ser Ser Ser Ala Ala Ser Ser Pro Ser Ser 
            100                 105                 110         


Gly Arg Ala Pro Gly Ala Ala Pro Ser Ala Ala Ala Lys Ser His Arg 
        115                 120                 125             


Cys Pro Phe Pro Asp Cys Ala Lys Ala Tyr Tyr Lys Ser Ser His Leu 
    130                 135                 140                 


Lys Ser His Leu Arg Thr His Thr Gly Glu Arg Pro Phe Ala Cys Asp 
145                 150                 155                 160 


Trp Gln Gly Cys Asp Lys Lys Phe Ala Arg Ser Asp Glu Leu Ala Arg 
                165                 170                 175     


His His Arg Thr His Thr Gly Glu Lys Arg Phe Ser Cys Pro Leu Cys 
            180                 185                 190         


Ser Lys Arg Phe Thr Arg Ser Asp His Leu Ala Lys His Ala Arg Arg 
        195                 200                 205             


His Pro Gly Phe His Pro Asp Leu Leu Arg Arg Pro Gly Ala Arg Ser 
    210                 215                 220                 


Thr Ser Pro Ser Asp Ser Leu Pro Cys Ser Leu Ala Gly Ser Pro Ala 
225                 230                 235                 240 


Pro Ser Pro Ala Pro Ser Pro Ala Pro Ala Gly Leu 
                245                 250         


<210>  5934
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF1__Homo_sapiens__NP_006554

<400>  5934

Met Ala Thr Ala Glu Thr Ala Leu Pro Ser Ile Ser Thr Leu Thr Ala 
1               5                   10                  15      


Leu Gly Pro Phe Pro Asp Thr Gln Asp Asp Phe Leu Lys Trp Trp Arg 
            20                  25                  30          


Ser Glu Glu Ala Gln Asp Met Gly Pro Gly Pro Pro Asp Pro Thr Glu 
        35                  40                  45              


Pro Pro Leu His Val Lys Ser Glu Asp Gln Pro Gly Glu Glu Glu Asp 
    50                  55                  60                  


Asp Glu Arg Gly Ala Asp Ala Thr Trp Asp Leu Asp Leu Leu Leu Thr 
65                  70                  75                  80  


Asn Phe Ser Gly Pro Glu Pro Gly Gly Ala Pro Gln Thr Cys Ala Leu 
                85                  90                  95      


Ala Pro Ser Glu Ala Ser Gly Ala Gln Tyr Pro Pro Pro Pro Glu Thr 
            100                 105                 110         


Leu Gly Ala Tyr Ala Gly Gly Pro Gly Leu Val Ala Gly Leu Leu Gly 
        115                 120                 125             


Ser Glu Asp His Ser Gly Trp Val Arg Pro Ala Leu Arg Ala Arg Ala 
    130                 135                 140                 


Pro Asp Ala Phe Val Gly Pro Ala Leu Ala Pro Ala Pro Ala Pro Glu 
145                 150                 155                 160 


Pro Lys Ala Leu Ala Leu Gln Pro Val Tyr Pro Gly Pro Gly Ala Gly 
                165                 170                 175     


Ser Ser Gly Gly Tyr Phe Pro Arg Thr Gly Leu Ser Val Pro Ala Ala 
            180                 185                 190         


Ser Gly Ala Pro Tyr Gly Leu Leu Ser Gly Tyr Pro Ala Met Tyr Pro 
        195                 200                 205             


Ala Pro Gln Tyr Gln Gly His Phe Gln Leu Phe Arg Gly Leu Gln Gly 
    210                 215                 220                 


Pro Ala Pro Gly Pro Ala Thr Ser Pro Ser Phe Leu Ser Cys Leu Gly 
225                 230                 235                 240 


Pro Gly Thr Val Gly Thr Gly Leu Gly Gly Thr Ala Glu Asp Pro Gly 
                245                 250                 255     


Val Ile Ala Glu Thr Ala Pro Ser Lys Arg Gly Arg Arg Ser Trp Ala 
            260                 265                 270         


Arg Lys Arg Gln Ala Ala His Thr Cys Ala His Pro Gly Cys Gly Lys 
        275                 280                 285             


Ser Tyr Thr Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Tyr Ala Cys Thr Trp Glu Gly Cys Gly Trp Arg Phe 
305                 310                 315                 320 


Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly Gln 
                325                 330                 335     


Arg Pro Phe Arg Cys Gln Leu Cys Pro Arg Ala Phe Ser Arg Ser Asp 
            340                 345                 350         


His Leu Ala Leu His Met Lys Arg His Leu 
        355                 360         


<210>  5935
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF2__Homo_sapiens__NP_057354

<400>  5935

Met Ala Leu Ser Glu Pro Ile Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Pro Cys Arg Glu Arg Gly Leu Gln Glu Arg Trp Pro Arg Ala Glu Pro 
            20                  25                  30          


Glu Ser Gly Gly Thr Asp Asp Asp Leu Asn Ser Val Leu Asp Phe Ile 
        35                  40                  45              


Leu Ser Met Gly Leu Asp Gly Leu Gly Ala Glu Ala Ala Pro Glu Pro 
    50                  55                  60                  


Pro Pro Pro Pro Pro Pro Pro Ala Phe Tyr Tyr Pro Glu Pro Gly Ala 
65                  70                  75                  80  


Pro Pro Pro Tyr Ser Ala Pro Ala Gly Gly Leu Val Ser Glu Leu Leu 
                85                  90                  95      


Arg Pro Glu Leu Asp Ala Pro Leu Gly Pro Ala Leu His Gly Arg Phe 
            100                 105                 110         


Leu Leu Ala Pro Pro Gly Arg Leu Val Lys Ala Glu Pro Pro Glu Ala 
        115                 120                 125             


Asp Gly Gly Gly Gly Tyr Gly Cys Ala Pro Gly Leu Thr Arg Gly Pro 
    130                 135                 140                 


Arg Gly Leu Lys Arg Glu Gly Ala Pro Gly Pro Ala Ala Ser Cys Met 
145                 150                 155                 160 


Arg Gly Pro Gly Gly Arg Pro Pro Pro Pro Pro Asp Thr Pro Pro Leu 
                165                 170                 175     


Ser Pro Asp Gly Pro Ala Arg Leu Pro Ala Pro Gly Pro Arg Ala Ser 
            180                 185                 190         


Phe Pro Pro Pro Phe Gly Gly Pro Gly Phe Gly Ala Pro Gly Pro Gly 
        195                 200                 205             


Leu His Tyr Ala Pro Pro Ala Pro Pro Ala Phe Gly Leu Phe Asp Asp 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Leu Gly Leu Ala Pro Pro Ala Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Thr Pro Pro Ala Ser Pro Leu Glu Leu Leu Glu Ala Lys 
                245                 250                 255     


Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His 
            260                 265                 270         


Thr Cys Ser Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His 
        275                 280                 285             


Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys 
    290                 295                 300                 


Asn Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr 
305                 310                 315                 320 


Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln Cys His Leu 
                325                 330                 335     


Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys 
            340                 345                 350         


Arg His Met 
        355 


<210>  5936
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF3__Homo_sapiens__NP_057615

<400>  5936

Met Leu Met Phe Asp Pro Val Pro Val Lys Gln Glu Ala Met Asp Pro 
1               5                   10                  15      


Val Ser Val Ser Tyr Pro Ser Asn Tyr Met Glu Ser Met Lys Pro Asn 
            20                  25                  30          


Lys Tyr Gly Val Ile Tyr Ser Thr Pro Leu Pro Glu Lys Phe Phe Gln 
        35                  40                  45              


Thr Pro Glu Gly Leu Ser His Gly Ile Gln Met Glu Pro Val Asp Leu 
    50                  55                  60                  


Thr Val Asn Lys Arg Ser Ser Pro Pro Ser Ala Gly Asn Ser Pro Ser 
65                  70                  75                  80  


Ser Leu Lys Phe Pro Ser Ser His Arg Arg Ala Ser Pro Gly Leu Ser 
                85                  90                  95      


Met Pro Ser Ser Ser Pro Pro Ile Lys Lys Tyr Ser Pro Pro Ser Pro 
            100                 105                 110         


Gly Val Gln Pro Phe Gly Val Pro Leu Ser Met Pro Pro Val Met Ala 
        115                 120                 125             


Ala Ala Leu Ser Arg His Gly Ile Arg Ser Pro Gly Ile Leu Pro Val 
    130                 135                 140                 


Ile Gln Pro Val Val Val Gln Pro Val Pro Phe Met Tyr Thr Ser His 
145                 150                 155                 160 


Leu Gln Gln Pro Leu Met Val Ser Leu Ser Glu Glu Met Glu Asn Ser 
                165                 170                 175     


Ser Ser Ser Met Gln Val Pro Val Ile Glu Ser Tyr Glu Lys Pro Ile 
            180                 185                 190         


Ser Gln Lys Lys Ile Lys Ile Glu Pro Gly Ile Glu Pro Gln Arg Thr 
        195                 200                 205             


Asp Tyr Tyr Pro Glu Glu Met Ser Pro Pro Leu Met Asn Ser Val Ser 
    210                 215                 220                 


Pro Pro Gln Ala Leu Leu Gln Glu Asn His Pro Ser Val Ile Val Gln 
225                 230                 235                 240 


Pro Gly Lys Arg Pro Leu Pro Val Glu Ser Pro Asp Thr Gln Arg Lys 
                245                 250                 255     


Arg Arg Ile His Arg Cys Asp Tyr Asp Gly Cys Asn Lys Val Tyr Thr 
            260                 265                 270         


Lys Ser Ser His Leu Lys Ala His Arg Arg Thr His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Thr Trp Glu Gly Cys Thr Trp Lys Phe Ala Arg Ser 
    290                 295                 300                 


Asp Glu Leu Thr Arg His Phe Arg Lys His Thr Gly Ile Lys Pro Phe 
305                 310                 315                 320 


Gln Cys Pro Asp Cys Asp Arg Ser Phe Ser Arg Ser Asp His Leu Ala 
                325                 330                 335     


Leu His Arg Lys Arg His Met Leu Val 
            340                 345 


<210>  5937
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF4__Homo_sapiens__NP_004226

<400>  5937

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  5938
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF5__Homo_sapiens__NP_001273747

<400>  5938

Met Glu Lys Tyr Leu Thr Pro Gln Leu Pro Pro Val Pro Ile Ile Pro 
1               5                   10                  15      


Glu His Lys Lys Tyr Arg Arg Asp Ser Ala Ser Val Val Asp Gln Phe 
            20                  25                  30          


Phe Thr Asp Thr Glu Gly Leu Pro Tyr Ser Ile Asn Met Asn Val Phe 
        35                  40                  45              


Leu Pro Asp Ile Thr His Leu Arg Thr Gly Leu Tyr Lys Ser Gln Arg 
    50                  55                  60                  


Pro Cys Val Thr His Ile Lys Thr Glu Pro Val Ala Ile Phe Ser His 
65                  70                  75                  80  


Gln Ser Glu Thr Thr Ala Pro Pro Pro Ala Pro Thr Gln Ala Leu Pro 
                85                  90                  95      


Glu Phe Thr Ser Ile Phe Ser Ser His Gln Thr Ala Ala Pro Glu Val 
            100                 105                 110         


Asn Asn Ile Phe Ile Lys Gln Glu Leu Pro Thr Pro Asp Leu His Leu 
        115                 120                 125             


Ser Val Pro Thr Gln Gln Gly His Leu Tyr Gln Leu Leu Asn Thr Pro 
    130                 135                 140                 


Asp Leu Asp Met Pro Ser Ser Thr Asn Gln Thr Ala Ala Met Asp Thr 
145                 150                 155                 160 


Leu Asn Val Ser Met Ser Ala Ala Met Ala Gly Leu Asn Thr His Thr 
                165                 170                 175     


Ser Ala Val Pro Gln Thr Ala Val Lys Gln Phe Gln Gly Met Pro Pro 
            180                 185                 190         


Cys Thr Tyr Thr Met Pro Ser Gln Phe Leu Pro Gln Gln Ala Thr Tyr 
        195                 200                 205             


Phe Pro Pro Ser Pro Pro Ser Ser Glu Pro Gly Ser Pro Asp Arg Gln 
    210                 215                 220                 


Ala Glu Met Leu Gln Asn Leu Thr Pro Pro Pro Ser Tyr Ala Ala Thr 
225                 230                 235                 240 


Ile Ala Ser Lys Leu Ala Ile His Asn Pro Asn Leu Pro Thr Thr Leu 
                245                 250                 255     


Pro Val Asn Ser Gln Asn Ile Gln Pro Val Arg Tyr Asn Arg Arg Ser 
            260                 265                 270         


Asn Pro Asp Leu Glu Lys Arg Arg Ile His Tyr Cys Asp Tyr Pro Gly 
        275                 280                 285             


Cys Thr Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Leu Arg 
    290                 295                 300                 


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu Gly Cys Asp 
305                 310                 315                 320 


Trp Arg Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys His 
                325                 330                 335     


Thr Gly Ala Lys Pro Phe Gln Cys Gly Val Cys Asn Arg Ser Phe Ser 
            340                 345                 350         


Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Gln Asn 
        355                 360                 365     


<210>  5939
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF6__Homo_sapiens__NP_001153597

<400>  5939

Met Asp Val Leu Pro Met Cys Ser Ile Phe Gln Glu Leu Gln Ile Val 
1               5                   10                  15      


His Glu Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Tyr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Ser Glu Pro Cys 
        35                  40                  45              


Tyr Val Ser Ala Ser Glu Ile Lys Phe Asp Ser Gln Glu Asp Leu Trp 
    50                  55                  60                  


Thr Lys Ile Ile Leu Ala Arg Glu Lys Lys Glu Glu Ser Glu Leu Lys 
65                  70                  75                  80  


Ile Ser Ser Ser Pro Pro Glu Asp Thr Leu Ile Ser Pro Ser Phe Cys 
                85                  90                  95      


Tyr Asn Leu Glu Thr Asn Ser Leu Asn Ser Asp Val Ser Ser Glu Ser 
            100                 105                 110         


Ser Asp Ser Ser Glu Glu Leu Ser Pro Thr Ala Lys Phe Thr Ser Asp 
        115                 120                 125             


Pro Ile Gly Glu Val Leu Val Ser Ser Gly Lys Leu Ser Ser Ser Val 
    130                 135                 140                 


Thr Ser Thr Pro Pro Ser Ser Pro Glu Leu Ser Arg Glu Pro Ser Gln 
145                 150                 155                 160 


Leu Trp Gly Cys Val Pro Gly Glu Leu Pro Ser Pro Gly Lys Val Arg 
                165                 170                 175     


Ser Gly Thr Ser Gly Lys Pro Gly Asp Lys Gly Asn Gly Asp Ala Ser 
            180                 185                 190         


Pro Asp Gly Arg Arg Arg Val His Arg Cys His Phe Asn Gly Cys Arg 
        195                 200                 205             


Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln Arg Thr His 
    210                 215                 220                 


Thr Gly Val Phe Pro Gly Leu Thr Thr Trp Pro Cys Thr 
225                 230                 235         


<210>  5940
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF7__Homo_sapiens__NP_001257871

<400>  5940

Met Asp Val Leu Ala Ser Tyr Ser Ile Phe Gln Glu Leu Gln Leu Val 
1               5                   10                  15      


His Asp Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Thr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Thr Glu Pro Arg 
        35                  40                  45              


Arg Ile Ser Glu Thr Phe Gly Glu Asp Leu Asp Cys Phe Leu His Ala 
    50                  55                  60                  


Ser Pro Pro Pro Cys Ile Glu Glu Ser Phe Arg Arg Leu Asp Pro Leu 
65                  70                  75                  80  


Leu Leu Pro Val Glu Ala Ala Ile Cys Glu Lys Ser Ser Ala Val Asp 
                85                  90                  95      


Ile Leu Leu Ser Arg Asp Lys Leu Leu Ser Glu Thr Cys Leu Ser Leu 
            100                 105                 110         


Gln Pro Ala Ser Ser Ser Leu Asp Ser Tyr Thr Ala Val Asn Gln Ala 
        115                 120                 125             


Gln Leu Asn Ala Val Thr Ser Leu Thr Pro Pro Ser Ser Pro Glu Leu 
    130                 135                 140                 


Ser Arg His Leu Val Lys Thr Ser Gln Thr Leu Ser Ala Val Asp Gly 
145                 150                 155                 160 


Thr Val Thr Leu Lys Leu Val Ala Lys Lys Ala Ala Leu Ser Ser Val 
                165                 170                 175     


Lys Val Arg Ser Leu Ile Ser Ala His Gly Arg Asp Val Ser Gly Val 
            180                 185                 190         


Leu His Glu Ala Met Ser Ser Arg Gly Thr Thr Gly Asn Thr Gln Val 
        195                 200                 205             


Gln Ser Pro Ser Asn Ala Thr Thr Ala Thr Gly Val Phe Pro Gly Leu 
    210                 215                 220                 


Thr Ile Leu Pro Ser Thr 
225                 230 


<210>  5941
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF8__Homo_sapiens__XP_005262036

<400>  5941

Met Val Asp Met Asp Lys Leu Ile Asn Asn Leu Glu Val Gln Leu Asn 
1               5                   10                  15      


Ser Glu Gly Gly Ser Met Gln Val Phe Lys Gln Val Thr Ala Ser Val 
            20                  25                  30          


Arg Asn Arg Asp Pro Pro Glu Ile Glu Tyr Arg Ser Asn Met Thr Ser 
        35                  40                  45              


Pro Thr Leu Leu Asp Ala Asn Pro Met Glu Asn Pro Ala Leu Phe Asn 
    50                  55                  60                  


Asp Ile Lys Ile Glu Pro Pro Glu Glu Leu Leu Ala Ser Asp Phe Ser 
65                  70                  75                  80  


Leu Pro Gln Val Glu Pro Val Asp Leu Ser Phe His Lys Pro Lys Ala 
                85                  90                  95      


Pro Leu Gln Pro Ala Ser Met Leu Gln Ala Pro Ile Arg Pro Pro Lys 
            100                 105                 110         


Pro Gln Ser Ser Pro Gln Thr Leu Val Val Ser Thr Ser Thr Ser Asp 
        115                 120                 125             


Met Ser Thr Ser Ala Asn Ile Pro Thr Val Leu Thr Pro Gly Ser Val 
    130                 135                 140                 


Leu Thr Ser Ser Gln Ser Thr Gly Ser Gln Gln Ile Leu His Val Ile 
145                 150                 155                 160 


His Thr Ile Pro Ser Val Ser Leu Pro Asn Lys Met Gly Gly Leu Lys 
                165                 170                 175     


Thr Ile Pro Val Val Val Gln Ser Leu Pro Met Val Tyr Thr Thr Leu 
            180                 185                 190         


Pro Ala Asp Gly Gly Pro Ala Ala Ile Thr Val Pro Leu Ile Gly Gly 
        195                 200                 205             


Asp Gly Lys Asn Ala Gly Ser Val Lys Val Asp Pro Thr Ser Met Ser 
    210                 215                 220                 


Pro Leu Glu Ile Pro Ser Asp Ser Glu Glu Ser Thr Ile Glu Ser Gly 
225                 230                 235                 240 


Ser Ser Ala Leu Gln Ser Leu Gln Gly Leu Gln Gln Glu Pro Ala Ala 
                245                 250                 255     


Met Ala Gln Met Gln Gly Glu Glu Ser Leu Asp Leu Lys Arg Arg Arg 
            260                 265                 270         


Ile His Gln Cys Asp Phe Ala Gly Cys Ser Lys Val Tyr Thr Lys Ser 
        275                 280                 285             


Ser His Leu Lys Ala His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Thr Trp Asp Gly Cys Ser Trp Lys Phe Ala Arg Ser Asp Glu 
305                 310                 315                 320 


Leu Thr Arg His Phe Arg Lys His Thr Gly Ile Lys Pro Phe Arg Cys 
                325                 330                 335     


Thr Asp Cys Asn Arg Ser Phe Ser Arg Ser Asp His Leu Ser Leu His 
            340                 345                 350         


Arg Arg Arg His Asp Thr Met 
        355                 


<210>  5942
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLF9__Homo_sapiens__NP_001197

<400>  5942

Met Ser Ala Ala Ala Tyr Met Asp Phe Val Ala Ala Gln Cys Leu Val 
1               5                   10                  15      


Ser Ile Ser Asn Arg Ala Ala Val Pro Glu His Gly Val Ala Pro Asp 
            20                  25                  30          


Ala Glu Arg Leu Arg Leu Pro Glu Arg Glu Val Thr Lys Glu His Gly 
        35                  40                  45              


Asp Pro Gly Asp Thr Trp Lys Asp Tyr Cys Thr Leu Val Thr Ile Ala 
    50                  55                  60                  


Lys Ser Leu Leu Asp Leu Asn Lys Tyr Arg Pro Ile Gln Thr Pro Ser 
65                  70                  75                  80  


Val Cys Ser Asp Ser Leu Glu Ser Pro Asp Glu Asp Met Gly Ser Asp 
                85                  90                  95      


Ser Asp Val Thr Thr Glu Ser Gly Ser Ser Pro Ser His Ser Pro Glu 
            100                 105                 110         


Glu Arg Gln Asp Pro Gly Ser Ala Pro Ser Pro Leu Ser Leu Leu His 
        115                 120                 125             


Pro Gly Val Ala Ala Lys Gly Lys His Ala Ser Glu Lys Arg His Lys 
    130                 135                 140                 


Cys Pro Tyr Ser Gly Cys Gly Lys Val Tyr Gly Lys Ser Ser His Leu 
145                 150                 155                 160 


Lys Ala His Tyr Arg Val His Thr Gly Glu Arg Pro Phe Pro Cys Thr 
                165                 170                 175     


Trp Pro Asp Cys Leu Lys Lys Phe Ser Arg Ser Asp Glu Leu Thr Arg 
            180                 185                 190         


His Tyr Arg Thr His Thr Gly Glu Lys Gln Phe Arg Cys Pro Leu Cys 
        195                 200                 205             


Glu Lys Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala Arg Arg 
    210                 215                 220                 


His Thr Glu Phe His Pro Ser Met Ile Lys Arg Ser Lys Lys Ala Leu 
225                 230                 235                 240 


Ala Asn Ala Leu 
                


<210>  5943
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHDC1__Homo_sapiens__NP_751943

<400>  5943

Met Ala Asp Ser Gln Leu Phe Cys Val Ala Glu Glu Arg Ser Gly His 
1               5                   10                  15      


Cys Ala Val Val Asp Gly Asn Phe Leu Tyr Val Trp Gly Gly Tyr Val 
            20                  25                  30          


Ser Ile Glu Asp Asn Glu Val Tyr Leu Pro Asn Asp Glu Ile Trp Thr 
        35                  40                  45              


Tyr Asp Ile Asp Ser Gly Leu Trp Arg Met His Leu Met Glu Gly Glu 
    50                  55                  60                  


Leu Pro Ala Ser Met Ser Gly Ser Cys Gly Ala Cys Ile Asn Gly Lys 
65                  70                  75                  80  


Leu Tyr Ile Phe Gly Gly Tyr Asp Asp Lys Gly Tyr Ser Asn Arg Leu 
                85                  90                  95      


Tyr Phe Val Asn Leu Arg Thr Arg Asp Glu Thr Tyr Ile Trp Glu Lys 
            100                 105                 110         


Ile Thr Asp Phe Glu Gly Gln Pro Pro Thr Pro Arg Asp Lys Leu Ser 
        115                 120                 125             


Cys Trp Val Tyr Lys Asp Arg Leu Ile Tyr Phe Gly Gly Tyr Gly Cys 
    130                 135                 140                 


Arg Arg His Ser Glu Leu Gln Asp Cys Phe Asp Val His Asp Ala Ser 
145                 150                 155                 160 


Trp Glu Glu Gln Ile Phe Trp Gly Trp His Asn Asp Val His Ile Phe 
                165                 170                 175     


Asp Thr Lys Thr Gln Thr Trp Phe Gln Pro Glu Ile Lys Gly Gly Val 
            180                 185                 190         


Pro Pro Gln Pro Arg Ala Ala His Thr Cys Ala Val Leu Gly Asn Lys 
        195                 200                 205             


Gly Tyr Ile Phe Gly Gly Arg Val Leu Gln Thr Arg Met Asn Asp Leu 
    210                 215                 220                 


His Tyr Leu Asn Leu Asp Thr Trp Thr Trp Ser Gly Arg Ile Thr Ile 
225                 230                 235                 240 


Asn Gly Glu Ser Pro Lys His Arg Ser Trp His Thr Leu Thr Pro Ile 
                245                 250                 255     


Ala Asp Asp Lys Leu Phe Leu Cys Gly Gly Leu Ser Ala Asp Asn Ile 
            260                 265                 270         


Pro Leu Ser Asp Gly Trp Ile His Asn Val Thr Thr Asn Cys Trp Lys 
        275                 280                 285             


Gln Leu Thr His Leu Pro Lys Thr Arg Pro Arg Leu Trp His Thr Ala 
    290                 295                 300                 


Cys Leu Gly Lys Glu Asn Glu Ile Met Val Phe Gly Gly Ser Lys Asp 
305                 310                 315                 320 


Asp Leu Leu Ala Leu Asp Thr Gly His Cys Asn Asp Leu Leu Ile Phe 
                325                 330                 335     


Gln Thr Gln Pro Tyr Ser Leu Leu Arg Ser Cys Leu Asp Cys Ile Gly 
            340                 345                 350         


Lys Asn Ser Ile Met Leu Glu Ser Gln Ile Ser Leu Leu Pro Pro Lys 
        355                 360                 365             


Leu Leu Gln Gln Val Leu Lys Lys Ile Thr Phe Trp Ala Ala Ala Asn 
    370                 375                 380                 


His Arg Glu Glu Gln Arg Val Gln Lys Glu Glu Thr Glu Asn Lys Tyr 
385                 390                 395                 400 


Gln Trp Ile Ser Ser Asn 
                405     


<210>  5944
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHDC2__Homo_sapiens__NP_055130

<400>  5944

Met Ala Asp Gly Asn Glu Asp Leu Arg Ala Asp Asp Leu Pro Gly Pro 
1               5                   10                  15      


Ala Phe Glu Ser Tyr Glu Ser Met Glu Leu Ala Cys Pro Ala Glu Arg 
            20                  25                  30          


Ser Gly His Val Ala Val Ser Asp Gly Arg His Met Phe Val Trp Gly 
        35                  40                  45              


Gly Tyr Lys Ser Asn Gln Val Arg Gly Leu Tyr Asp Phe Tyr Leu Pro 
    50                  55                  60                  


Arg Glu Glu Leu Trp Ile Tyr Asn Met Glu Thr Gly Arg Trp Lys Lys 
65                  70                  75                  80  


Ile Asn Thr Glu Gly Asp Val Pro Pro Ser Met Ser Gly Ser Cys Ala 
                85                  90                  95      


Val Cys Val Asp Arg Val Leu Tyr Leu Phe Gly Gly His His Ser Arg 
            100                 105                 110         


Gly Asn Thr Asn Lys Phe Tyr Met Leu Asp Ser Arg Ser Thr Asp Arg 
        115                 120                 125             


Val Leu Gln Trp Glu Arg Ile Asp Cys Gln Gly Ile Pro Pro Ser Ser 
    130                 135                 140                 


Lys Asp Lys Leu Gly Val Trp Val Tyr Lys Asn Lys Leu Ile Phe Phe 
145                 150                 155                 160 


Gly Gly Tyr Gly Tyr Leu Pro Glu Asp Lys Val Leu Gly Thr Phe Glu 
                165                 170                 175     


Phe Asp Glu Thr Ser Phe Trp Asn Ser Ser His Pro Arg Gly Trp Asn 
            180                 185                 190         


Asp His Val His Ile Leu Asp Thr Glu Thr Phe Thr Trp Ser Gln Pro 
        195                 200                 205             


Ile Thr Thr Gly Lys Ala Pro Ser Pro Arg Ala Ala His Ala Cys Ala 
    210                 215                 220                 


Thr Val Gly Asn Arg Gly Phe Val Phe Gly Gly Arg Tyr Arg Asp Ala 
225                 230                 235                 240 


Arg Met Asn Asp Leu His Tyr Leu Asn Leu Asp Thr Trp Glu Trp Asn 
                245                 250                 255     


Glu Leu Ile Pro Gln Gly Ile Cys Pro Val Gly Arg Ser Trp His Ser 
            260                 265                 270         


Leu Thr Pro Val Ser Ser Asp His Leu Phe Leu Phe Gly Gly Phe Thr 
        275                 280                 285             


Thr Asp Lys Gln Pro Leu Ser Asp Ala Trp Thr Tyr Cys Ile Ser Lys 
    290                 295                 300                 


Asn Glu Trp Ile Gln Phe Asn His Pro Tyr Thr Glu Lys Pro Arg Leu 
305                 310                 315                 320 


Trp His Thr Ala Cys Ala Ser Asp Glu Gly Glu Val Ile Val Phe Gly 
                325                 330                 335     


Gly Cys Ala Asn Asn Leu Leu Val His His Arg Ala Ala His Ser Asn 
            340                 345                 350         


Glu Ile Leu Ile Phe Ser Val Gln Pro Lys Ser Leu Val Arg Leu Ser 
        355                 360                 365             


Leu Glu Ala Val Ile Cys Phe Lys Glu Met Leu Ala Asn Ser Trp Asn 
    370                 375                 380                 


Cys Leu Pro Lys His Leu Leu His Ser Val Asn Gln Arg Phe Gly Ser 
385                 390                 395                 400 


Asn Asn Thr Ser Gly Ser 
                405     


<210>  5945
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHDC8A__Homo_sapiens__XP_006711492

<400>  5945

Met Glu Val Pro Asn Val Lys Asp Phe Gln Trp Lys Arg Leu Ala Pro 
1               5                   10                  15      


Leu Pro Ser Arg Arg Val Tyr Cys Ser Leu Leu Glu Thr Gly Gly Gln 
            20                  25                  30          


Val Tyr Ala Ile Gly Gly Cys Asp Asp Asn Gly Val Pro Met Asp Cys 
        35                  40                  45              


Phe Glu Val Tyr Ser Pro Glu Ala Asp Gln Trp Thr Ala Leu Pro Arg 
    50                  55                  60                  


Leu Pro Thr Ala Arg Ala Gly Val Ala Val Thr Ala Leu Gly Lys Arg 
65                  70                  75                  80  


Ile Met Val Ile Gly Gly Val Gly Thr Asn Gln Leu Pro Leu Lys Val 
                85                  90                  95      


Val Glu Met Tyr Asn Ile Asp Glu Gly Lys Trp Lys Lys Arg Ser Met 
            100                 105                 110         


Leu Arg Glu Ala Ala Met Gly Ile Ser Val Thr Ala Lys Asp Tyr Arg 
        115                 120                 125             


Val Tyr Ala Ala Gly Gly Met Gly Leu Asp Leu Arg Pro His Asn His 
    130                 135                 140                 


Leu Gln His Tyr Asp Met Leu Lys Asp Met Trp Val Ser Leu Ala Pro 
145                 150                 155                 160 


Met Pro Thr Pro Arg Tyr Ala Ala Thr Ser Phe Leu Arg Gly Ser Lys 
                165                 170                 175     


Ile Tyr Val Leu Gly Gly Arg Gln Ser Lys Tyr Ala Val Asn Ala Phe 
            180                 185                 190         


Glu Val Phe Asp Ile Glu Thr Arg Ser Trp Thr Lys Phe Pro Asn Ile 
        195                 200                 205             


Pro Tyr Lys Arg Ala Phe Ser Ser Phe Val Thr Leu Asp Asn His Leu 
    210                 215                 220                 


Tyr Ser Leu Gly Gly Leu Arg Gln Gly Arg Leu Tyr Arg Gln Pro Lys 
225                 230                 235                 240 


Phe Leu Arg Thr Met Asp Val Phe Asp Met Glu Gln Gly Gly Trp Leu 
                245                 250                 255     


Lys Met Glu Arg Ser Phe Phe Leu Lys Lys Arg Arg Ala Asp Phe Val 
            260                 265                 270         


Ala Gly Ser Leu Ser Gly Arg Val Ile Val Ala Gly Gly Leu Gly Asn 
        275                 280                 285             


Gln Pro Thr Val Leu Glu Thr Ala Glu Ala Phe His Pro Gly Lys Asn 
    290                 295                 300                 


Lys Trp Glu Ile Leu Pro Ala Met Pro Thr Pro Arg Cys Ala Cys Ser 
305                 310                 315                 320 


Ser Ile Val Val Lys Asn Cys Leu Leu Ala Val Gly Gly Val Asn Gln 
                325                 330                 335     


Gly Leu Ser Asp Ala Val Glu Ala Leu Cys Val Ser Asp Ser 
            340                 345                 350 


<210>  5946
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHDC8B__Homo_sapiens__NP_775817

<400>  5946

Met Ser Ala Gly Gly Gly Arg Ala Phe Ala Trp Gln Val Phe Pro Pro 
1               5                   10                  15      


Met Pro Thr Cys Arg Val Tyr Gly Thr Val Ala His Gln Asp Gly His 
            20                  25                  30          


Leu Leu Val Leu Gly Gly Cys Gly Arg Ala Gly Leu Pro Leu Asp Thr 
        35                  40                  45              


Ala Glu Thr Leu Asp Met Ala Ser His Thr Trp Leu Ala Leu Ala Pro 
    50                  55                  60                  


Leu Pro Thr Ala Arg Ala Gly Ala Ala Ala Val Val Leu Gly Lys Gln 
65                  70                  75                  80  


Val Leu Val Val Gly Gly Val Asp Glu Val Gln Ser Pro Val Ala Ala 
                85                  90                  95      


Val Glu Ala Phe Leu Met Asp Glu Gly Arg Trp Glu Arg Arg Ala Thr 
            100                 105                 110         


Leu Pro Gln Ala Ala Met Gly Val Ala Thr Val Glu Arg Asp Gly Met 
        115                 120                 125             


Val Tyr Ala Leu Gly Gly Met Gly Pro Asp Thr Ala Pro Gln Ala Gln 
    130                 135                 140                 


Val Arg Val Tyr Glu Pro Arg Arg Asp Cys Trp Leu Ser Leu Pro Ser 
145                 150                 155                 160 


Met Pro Thr Pro Cys Tyr Gly Ala Ser Thr Phe Leu His Gly Asn Lys 
                165                 170                 175     


Ile Tyr Val Leu Gly Gly Arg Gln Gly Lys Leu Pro Val Thr Ala Phe 
            180                 185                 190         


Glu Ala Phe Asp Leu Glu Ala Arg Thr Trp Thr Arg His Pro Ser Leu 
        195                 200                 205             


Pro Ser Arg Arg Ala Phe Ala Gly Cys Ala Met Ala Glu Gly Ser Val 
    210                 215                 220                 


Phe Ser Leu Gly Gly Leu Gln Gln Pro Gly Pro His Asn Phe Tyr Ser 
225                 230                 235                 240 


Arg Pro His Phe Val Asn Thr Val Glu Met Phe Asp Leu Glu His Gly 
                245                 250                 255     


Ser Trp Thr Lys Leu Pro Arg Ser Leu Arg Met Arg Asp Lys Arg Ala 
            260                 265                 270         


Asp Phe Val Val Gly Ser Leu Gly Gly His Ile Val Ala Ile Gly Gly 
        275                 280                 285             


Leu Gly Asn Gln Pro Cys Pro Leu Gly Ser Val Glu Ser Phe Ser Leu 
    290                 295                 300                 


Ala Arg Arg Arg Trp Glu Ala Leu Pro Ala Met Pro Thr Ala Arg Cys 
305                 310                 315                 320 


Ser Cys Ser Ser Leu Gln Ala Gly Pro Arg Leu Phe Val Ile Gly Gly 
                325                 330                 335     


Val Ala Gln Gly Pro Ser Gln Ala Val Glu Ala Leu Cys Leu Arg Asp 
            340                 345                 350         


Gly Val 
        


<210>  5947
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL10__Homo_sapiens__NP_689680

<400>  5947

Met Glu Met Glu Ser Ala Ala Ala Ser Thr Arg Phe His Gln Pro His 
1               5                   10                  15      


Met Glu Arg Lys Met Ser Ala Met Ala Cys Glu Ile Phe Asn Glu Leu 
            20                  25                  30          


Arg Leu Glu Gly Lys Leu Cys Asp Val Val Ile Lys Val Asn Gly Phe 
        35                  40                  45              


Glu Phe Ser Ala His Lys Asn Ile Leu Cys Ser Cys Ser Ser Tyr Phe 
    50                  55                  60                  


Arg Ala Leu Phe Thr Ser Gly Trp Asn Asn Thr Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Asn Ile Pro Gly Ile Ser Pro Asp Met Met Lys Leu Ile Ile Glu Tyr 
                85                  90                  95      


Ala Tyr Thr Arg Thr Val Pro Ile Thr Pro Asp Asn Val Glu Lys Leu 
            100                 105                 110         


Leu Ala Ala Ala Asp Gln Phe Asn Ile Met Gly Ile Val Arg Gly Cys 
        115                 120                 125             


Cys Glu Phe Leu Lys Ser Glu Leu Cys Leu Asp Asn Cys Ile Gly Ile 
    130                 135                 140                 


Cys Lys Phe Thr Asp Tyr Tyr Tyr Cys Pro Glu Leu Arg Gln Lys Ala 
145                 150                 155                 160 


Tyr Met Phe Ile Leu His Asn Phe Glu Glu Met Val Lys Val Ser Ala 
                165                 170                 175     


Glu Phe Leu Glu Leu Ser Val Thr Glu Leu Lys Asp Ile Ile Glu Lys 
            180                 185                 190         


Asp Glu Leu Asn Val Lys Gln Glu Asp Ala Val Phe Glu Ala Ile Leu 
        195                 200                 205             


Lys Trp Ile Ser His Asp Pro Gln Asn Arg Lys Gln His Ile Ser Ile 
    210                 215                 220                 


Leu Leu Pro Lys Val Arg Leu Ala Leu Met His Ala Glu Tyr Phe Met 
225                 230                 235                 240 


Asn Asn Val Lys Met Asn Asp Tyr Val Lys Asp Ser Glu Glu Cys Lys 
                245                 250                 255     


Pro Val Ile Ile Asn Ala Leu Lys Ala Met Tyr Asp Leu Asn Met Asn 
            260                 265                 270         


Gly Pro Ser Asn Ser Asp Phe Thr Asn Pro Leu Thr Arg Pro Arg Leu 
        275                 280                 285             


Pro Tyr Ala Ile Leu Phe Ala Ile Gly Gly Trp Ser Gly Gly Ser Pro 
    290                 295                 300                 


Thr Asn Ala Ile Glu Ala Tyr Asp Ala Arg Ala Asp Arg Trp Val Asn 
305                 310                 315                 320 


Val Thr Cys Glu Glu Glu Ser Pro Arg Ala Tyr His Gly Ala Ala Tyr 
                325                 330                 335     


Leu Lys Gly Tyr Val Tyr Ile Ile Gly Gly Phe Asp Ser Val Asp Tyr 
            340                 345                 350         


Phe Asn Ser Val Lys Arg Phe Asp Pro Val Lys Lys Thr Trp His Gln 
        355                 360                 365             


Val Ala Pro Met His Ser Arg Arg Cys Tyr Val Ser Val Thr Val Leu 
    370                 375                 380                 


Gly Asn Phe Ile Tyr Ala Met Gly Gly Phe Asp Gly Tyr Val Arg Leu 
385                 390                 395                 400 


Asn Thr Ala Glu Arg Tyr Glu Pro Glu Thr Asn Gln Trp Thr Leu Ile 
                405                 410                 415     


Ala Pro Met His Glu Gln Arg Ser Asp Ala Ser Ala Thr Thr Leu Tyr 
            420                 425                 430         


Gly Lys Val Tyr Ile Cys Gly Gly Phe Asn Gly Asn Glu Cys Leu Phe 
        435                 440                 445             


Thr Ala Glu Val Tyr Asn Thr Glu Ser Asn Gln Trp Thr Val Ile Ala 
    450                 455                 460                 


Pro Met Arg Ser Arg Arg Ser Gly Ile Gly Val Ile Ala Tyr Gly Glu 
465                 470                 475                 480 


His Val Tyr Ala Val Gly Gly Phe Asp Gly Ala Asn Arg Leu Arg Ser 
                485                 490                 495     


Ala Glu Ala Tyr Ser Pro Val Ala Asn Thr Trp Arg Thr Ile Pro Thr 
            500                 505                 510         


Met Phe Asn Pro Arg Ser Asn Phe Gly Ile Glu Val Val Asp Asp Leu 
        515                 520                 525             


Leu Phe Val Val Gly Gly Phe Asn Gly Phe Thr Thr Thr Phe Asn Val 
    530                 535                 540                 


Glu Cys Tyr Asp Glu Lys Thr Asp Glu Trp Tyr Asp Ala His Asp Met 
545                 550                 555                 560 


Ser Ile Tyr Arg Ser Ala Leu Ser Cys Cys Val Val Pro Gly Leu Ala 
                565                 570                 575     


Asn Val Glu Glu Tyr Ala Ala Arg Arg Asp Asn Phe Pro Gly Leu Ala 
            580                 585                 590         


Leu Arg Asp Glu Val Lys Tyr Ser Ala Ser Thr Ser Thr Leu Pro Val 
        595                 600                 605             


<210>  5948
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL12__Homo_sapiens__NP_001289980

<400>  5948

Met Asp Val Asn Lys Phe Glu Ala Ser Val Gly Phe Leu Asp Val Lys 
1               5                   10                  15      


Lys Phe Leu Ser Thr Trp Lys Leu Gln Asn Pro Arg Thr His Phe Val 
            20                  25                  30          


Leu Ser Pro His Cys Phe Met Gly Gly Ile Met Ala Pro Lys Asp Ile 
        35                  40                  45              


Met Thr Asn Thr His Ala Lys Ser Ile Leu Asn Ser Met Asn Ser Leu 
    50                  55                  60                  


Arg Lys Ser Asn Thr Leu Cys Asp Val Thr Leu Arg Val Glu Gln Lys 
65                  70                  75                  80  


Asp Phe Pro Ala His Arg Ile Val Leu Ala Ala Cys Ser Asp Tyr Phe 
                85                  90                  95      


Cys Ala Met Phe Thr Ser Glu Leu Ser Glu Lys Gly Lys Pro Tyr Val 
            100                 105                 110         


Asp Ile Gln Gly Leu Thr Ala Ser Thr Met Glu Ile Leu Leu Asp Phe 
        115                 120                 125             


Val Tyr Thr Glu Thr Val His Val Thr Val Glu Asn Val Gln Glu Leu 
    130                 135                 140                 


Leu Pro Ala Ala Cys Leu Leu Gln Leu Lys Gly Val Lys Gln Ala Cys 
145                 150                 155                 160 


Cys Glu Phe Leu Glu Ser Gln Leu Asp Pro Ser Asn Cys Leu Gly Ile 
                165                 170                 175     


Arg Asp Phe Ala Glu Thr His Asn Cys Val Asp Leu Met Gln Ala Ala 
            180                 185                 190         


Glu Val Phe Ser Gln Lys His Phe Pro Glu Val Val Gln His Glu Glu 
        195                 200                 205             


Phe Ile Leu Leu Ser Gln Gly Glu Val Glu Lys Leu Ile Lys Cys Asp 
    210                 215                 220                 


Glu Ile Gln Val Asp Ser Glu Glu Pro Val Phe Glu Ala Val Ile Asn 
225                 230                 235                 240 


Trp Val Lys His Ala Lys Lys Glu Arg Glu Glu Ser Leu Pro Asn Leu 
                245                 250                 255     


Leu Gln Tyr Val Arg Met Pro Leu Leu Thr Pro Arg Tyr Ile Thr Asp 
            260                 265                 270         


Val Ile Asp Ala Glu Pro Phe Ile Arg Cys Ser Leu Gln Cys Arg Asp 
        275                 280                 285             


Leu Val Asp Glu Ala Lys Lys Phe His Leu Arg Pro Glu Leu Arg Ser 
    290                 295                 300                 


Gln Met Gln Gly Pro Arg Thr Arg Ala Arg Leu Gly Ala Asn Glu Val 
305                 310                 315                 320 


Leu Leu Val Val Gly Gly Phe Gly Ser Gln Gln Ser Pro Ile Asp Val 
                325                 330                 335     


Val Glu Lys Tyr Asp Pro Lys Thr Gln Glu Trp Ser Phe Leu Pro Ser 
            340                 345                 350         


Ile Thr Arg Lys Arg Arg Tyr Val Ala Ser Val Ser Leu His Asp Arg 
        355                 360                 365             


Ile Tyr Val Ile Gly Gly Tyr Asp Gly Arg Ser Arg Leu Ser Ser Val 
    370                 375                 380                 


Glu Cys Leu Asp Tyr Thr Ala Asp Glu Asp Gly Val Trp Tyr Ser Val 
385                 390                 395                 400 


Ala Pro Met Asn Val Arg Arg Gly Leu Ala Gly Ala Thr Thr Leu Gly 
                405                 410                 415     


Asp Met Ile Tyr Val Ser Gly Gly Phe Asp Gly Ser Arg Arg His Thr 
            420                 425                 430         


Ser Met Glu Arg Tyr Asp Pro Asn Ile Asp Gln Trp Ser Met Leu Gly 
        435                 440                 445             


Asp Met Gln Thr Ala Arg Glu Gly Ala Gly Leu Val Val Ala Ser Gly 
    450                 455                 460                 


Val Ile Tyr Cys Leu Gly Gly Tyr Asp Gly Leu Asn Ile Leu Asn Ser 
465                 470                 475                 480 


Val Glu Lys Tyr Asp Pro His Thr Gly His Trp Thr Asn Val Thr Pro 
                485                 490                 495     


Met Ala Thr Lys Arg Ser Gly Ala Gly Val Ala Leu Leu Asn Asp His 
            500                 505                 510         


Ile Tyr Val Val Gly Gly Phe Asp Gly Thr Ala His Leu Ser Ser Val 
        515                 520                 525             


Glu Ala Tyr Asn Ile Arg Thr Asp Ser Trp Thr Thr Val Thr Ser Met 
    530                 535                 540                 


Thr Thr Pro Arg Cys Tyr Val Gly Ala Thr Val Leu Arg Gly Arg Leu 
545                 550                 555                 560 


Tyr Ala Ile Ala Gly Tyr Asp Gly Asn Ser Leu Leu Ser Ser Ile Glu 
                565                 570                 575     


Cys Tyr Asp Pro Ile Ile Asp Ser Trp Glu Val Val Thr Ser Met Gly 
            580                 585                 590         


Thr Gln Arg Cys Asp Ala Gly Val Cys Val Leu Arg Glu Lys 
        595                 600                 605     


<210>  5949
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL1__Homo_sapiens__NP_001273654

<400>  5949

Met Ser Gly Ser Gly Arg Lys Asp Phe Asp Val Lys His Ile Leu Arg 
1               5                   10                  15      


Leu Arg Trp Lys Leu Phe Ser His Pro Ser Pro Ser Thr Gly Gly Pro 
            20                  25                  30          


Ala Gly Gly Gly Cys Leu Gln Gln Asp Gly Ser Gly Ser Phe Glu His 
        35                  40                  45              


Trp Gly Pro Ser Gln Ser Arg Leu Leu Lys Ser Gln Glu Arg Ser Gly 
    50                  55                  60                  


Val Ser Thr Phe Trp Lys Lys Pro Ser Ser Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Ser Ser Ser Ser Ser Ser Phe Asn Pro Leu Asn Gly Thr Leu 
                85                  90                  95      


Leu Pro Val Ala Thr Arg Leu Gln Gln Gly Ala Pro Gly Gln Gly Thr 
            100                 105                 110         


Gln Gln Pro Ala Arg Thr Leu Phe Tyr Val Glu Ser Leu Glu Glu Glu 
        115                 120                 125             


Val Val Pro Gly Met Asp Phe Pro Gly Pro His Glu Lys Gly Leu Val 
    130                 135                 140                 


Leu Gln Glu Leu Lys Val Glu Pro Asp Asn Ser Ser Gln Ala Thr Gly 
145                 150                 155                 160 


Glu Gly Cys Gly His Arg Leu Val Leu Ser Ser Val Ser Asp Tyr Phe 
                165                 170                 175     


Ala Ala Met Phe Thr Ser Asp Val Cys Glu Ala Lys Gln Glu Glu Ile 
            180                 185                 190         


Lys Met Glu Gly Ile Asp Pro Asn Ala Leu Trp Asp Leu Val Gln Phe 
        195                 200                 205             


Ala Tyr Thr Gly Cys Leu Glu Leu Lys Glu Asp Thr Ile Glu Asn Leu 
    210                 215                 220                 


Leu Ala Ala Ala Cys Leu Leu Gln Leu Pro Gln Val Val Glu Val Cys 
225                 230                 235                 240 


Cys His Phe Leu Met Lys Leu Leu His Pro Ser Asn Cys Leu Gly Ile 
                245                 250                 255     


Arg Ala Phe Ala Asp Ala Gln Gly Cys Ile Glu Leu Met Lys Val Ala 
            260                 265                 270         


His Ser Tyr Thr Met Glu Asn Ile Met Glu Val Ile Arg Asn Gln Glu 
        275                 280                 285             


Phe Leu Leu Leu Pro Ala Glu Glu Leu His Lys Leu Leu Ala Ser Asp 
    290                 295                 300                 


Asp Val Asn Val Pro Asp Glu Glu Thr Ile Phe His Ala Leu Met Met 
305                 310                 315                 320 


Trp Val Lys Tyr Asp Met Gln Ser Arg Cys Asn Asp Leu Ser Met Leu 
                325                 330                 335     


Leu Ala Phe Ile Arg Leu Pro Leu Leu Pro Pro Gln Ile Leu Ala Asp 
            340                 345                 350         


Leu Glu Asn His Ala Leu Phe Lys Asn Asp Leu Glu Cys Gln Lys Leu 
        355                 360                 365             


Ile Leu Glu Ala Met Lys Tyr His Leu Leu Pro Glu Arg Arg Thr Leu 
    370                 375                 380                 


Met Gln Ser Pro Arg Thr Lys Pro Arg Lys Ser Thr Val Gly Thr Leu 
385                 390                 395                 400 


Tyr Ala Val Gly Gly Met Asp Asn Asn Lys Gly Ala Thr Thr Ile Glu 
                405                 410                 415     


Lys Tyr Asp Leu Arg Thr Asn Leu Trp Ile Gln Ala Gly Met Met Asn 
            420                 425                 430         


Gly Arg Arg Leu Gln Phe Gly Val Ala Val Ile Asp Asp Lys Leu Phe 
        435                 440                 445             


Val Ile Gly Gly Arg Asp Gly Leu Lys Thr Leu Asn Thr Val Glu Cys 
    450                 455                 460                 


Tyr Asn Pro Lys Thr Lys Thr Trp Thr Val Leu Pro Pro Met Ser Thr 
465                 470                 475                 480 


His Arg His Gly Leu Gly Val Thr Val Leu Glu Gly Pro Ile Tyr Ala 
                485                 490                 495     


Val Gly Gly His Asp Gly Trp Ser Tyr Leu Asn Thr Val Glu Arg Trp 
            500                 505                 510         


Asp Pro Gln Ser Gln Gln Trp Thr Phe Val Ala Ser Met Ser Ile Ala 
        515                 520                 525             


Arg Ser Thr Val Gly Val Ala Ala Leu Asn Gly Lys Leu Tyr Ser Val 
    530                 535                 540                 


Gly Gly Arg Asp Gly Ser Ser Cys Leu Ser Ser Met Glu Tyr Tyr Asp 
545                 550                 555                 560 


Pro His Thr Asn Lys Trp Asn Met Cys Ala Pro Met Cys Lys Arg Arg 
                565                 570                 575     


Gly Gly Val Gly Val Ala Thr Cys Asp Gly Phe Leu Tyr Ala Val Gly 
            580                 585                 590         


Gly His Asp Ala Pro Ala Ser Asn His Cys Ser Arg Leu Leu Asp Tyr 
        595                 600                 605             


Val Glu Arg Tyr Asp Pro Lys Thr Asp Thr Trp Thr Met Val Ala Pro 
    610                 615                 620                 


Leu Ser Met Pro Arg Asp Ala Val Gly Val Cys Leu Leu Gly Asp Arg 
625                 630                 635                 640 


Leu Tyr Ala Val Gly Gly Tyr Asp Gly Gln Thr Tyr Leu Asn Thr Met 
                645                 650                 655     


Glu Ser Tyr Asp Pro Gln Thr Asn Glu Trp Thr Gln Met Ala Ser Leu 
            660                 665                 670         


Asn Ile Gly Arg Ala Gly Ala Cys Val Val Val Ile Lys Gln Pro 
        675                 680                 685         


<210>  5950
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL20__Homo_sapiens__NP_055273

<400>  5950

Met Glu Gly Lys Pro Met Arg Arg Cys Thr Asn Ile Arg Pro Gly Glu 
1               5                   10                  15      


Thr Gly Met Asp Val Thr Ser Arg Cys Thr Leu Gly Asp Pro Asn Lys 
            20                  25                  30          


Leu Pro Glu Gly Val Pro Gln Pro Ala Arg Met Pro Tyr Ile Ser Asp 
        35                  40                  45              


Lys His Pro Arg Gln Thr Leu Glu Val Ile Asn Leu Leu Arg Lys His 
    50                  55                  60                  


Arg Glu Leu Cys Asp Val Val Leu Val Val Gly Ala Lys Lys Ile Tyr 
65                  70                  75                  80  


Ala His Arg Val Ile Leu Ser Ala Cys Ser Pro Tyr Phe Arg Ala Met 
                85                  90                  95      


Phe Thr Gly Glu Leu Ala Glu Ser Arg Gln Thr Glu Val Val Ile Arg 
            100                 105                 110         


Asp Ile Asp Glu Arg Ala Met Glu Leu Leu Ile Asp Phe Ala Tyr Thr 
        115                 120                 125             


Ser Gln Ile Thr Val Glu Glu Gly Asn Val Gln Thr Leu Leu Pro Ala 
    130                 135                 140                 


Ala Cys Leu Leu Gln Leu Ala Glu Ile Gln Glu Ala Cys Cys Glu Phe 
145                 150                 155                 160 


Leu Lys Arg Gln Leu Asp Pro Ser Asn Cys Leu Gly Ile Arg Ala Phe 
                165                 170                 175     


Ala Asp Thr His Ser Cys Arg Glu Leu Leu Arg Ile Ala Asp Lys Phe 
            180                 185                 190         


Thr Gln His Asn Phe Gln Glu Val Met Glu Ser Glu Glu Phe Met Leu 
        195                 200                 205             


Leu Pro Ala Asn Gln Leu Ile Asp Ile Ile Ser Ser Asp Glu Leu Asn 
    210                 215                 220                 


Val Arg Ser Glu Glu Gln Val Phe Asn Ala Val Met Ala Trp Val Lys 
225                 230                 235                 240 


Tyr Ser Ile Gln Glu Arg Arg Pro Gln Leu Pro Gln Val Leu Gln His 
                245                 250                 255     


Val Arg Leu Pro Leu Leu Ser Pro Lys Phe Leu Val Gly Thr Val Gly 
            260                 265                 270         


Ser Asp Pro Leu Ile Lys Ser Asp Glu Glu Cys Arg Asp Leu Val Asp 
        275                 280                 285             


Glu Ala Lys Asn Tyr Leu Leu Leu Pro Gln Glu Arg Pro Leu Met Gln 
    290                 295                 300                 


Gly Pro Arg Thr Arg Pro Arg Lys Pro Ile Arg Cys Gly Glu Val Leu 
305                 310                 315                 320 


Phe Ala Val Gly Gly Trp Cys Ser Gly Asp Ala Ile Ser Ser Val Glu 
                325                 330                 335     


Arg Tyr Asp Pro Gln Thr Asn Glu Trp Arg Met Val Ala Ser Met Ser 
            340                 345                 350         


Lys Arg Arg Cys Gly Val Gly Val Ser Val Leu Asp Asp Leu Leu Tyr 
        355                 360                 365             


Ala Val Gly Gly His Asp Gly Ser Ser Tyr Leu Asn Ser Val Glu Arg 
    370                 375                 380                 


Tyr Asp Pro Lys Thr Asn Gln Trp Ser Ser Asp Val Ala Pro Thr Ser 
385                 390                 395                 400 


Thr Cys Arg Thr Ser Val Gly Val Ala Val Leu Gly Gly Phe Leu Tyr 
                405                 410                 415     


Ala Val Gly Gly Gln Asp Gly Val Ser Cys Leu Asn Ile Val Glu Arg 
            420                 425                 430         


Tyr Asp Pro Lys Glu Asn Lys Trp Thr Arg Val Ala Ser Met Ser Thr 
        435                 440                 445             


Arg Arg Leu Gly Val Ala Val Ala Val Leu Gly Gly Phe Leu Tyr Ala 
    450                 455                 460                 


Val Gly Gly Ser Asp Gly Thr Ser Pro Leu Asn Thr Val Glu Arg Tyr 
465                 470                 475                 480 


Asn Pro Gln Glu Asn Arg Trp His Thr Ile Ala Pro Met Gly Thr Arg 
                485                 490                 495     


Arg Lys His Leu Gly Cys Ala Val Tyr Gln Asp Met Ile Tyr Ala Val 
            500                 505                 510         


Gly Gly Arg Asp Asp Thr Thr Glu Leu Ser Ser Ala Glu Arg Tyr Asn 
        515                 520                 525             


Pro Arg Thr Asn Gln Trp Ser Pro Val Val Ala Met Thr Ser Arg Arg 
    530                 535                 540                 


Ser Gly Val Gly Leu Ala Val Val Asn Gly Gln Leu Met Ala Val Gly 
545                 550                 555                 560 


Gly Phe Asp Gly Thr Thr Tyr Leu Lys Thr Ile Glu Val Phe Asp Pro 
                565                 570                 575     


Asp Ala Asn Thr Trp Arg Leu Tyr Gly Gly Met Asn Tyr Arg Arg Leu 
            580                 585                 590         


Gly Gly Gly Val Gly Val Ile Lys Met Thr His Cys Glu Ser His Ile 
        595                 600                 605             


Trp 
    


<210>  5951
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL25__Homo_sapiens__NP_071925

<400>  5951

Met Ser Val Ser Val His Glu Thr Arg Lys Ser Arg Ser Ser Thr Gly 
1               5                   10                  15      


Ser Met Asn Val Thr Leu Phe His Lys Ala Ser His Pro Asp Cys Val 
            20                  25                  30          


Leu Ala His Leu Asn Thr Leu Arg Lys His Cys Met Phe Thr Asp Val 
        35                  40                  45              


Thr Leu Trp Ala Gly Asp Arg Ala Phe Pro Cys His Arg Ala Val Leu 
    50                  55                  60                  


Ala Ala Ser Ser Arg Tyr Phe Glu Ala Met Phe Ser His Gly Leu Arg 
65                  70                  75                  80  


Glu Ser Arg Asp Asp Thr Val Asn Phe Gln Asp Asn Leu His Pro Glu 
                85                  90                  95      


Val Leu Glu Leu Leu Leu Asp Phe Ala Tyr Ser Ser Arg Ile Ala Ile 
            100                 105                 110         


Asn Glu Glu Asn Ala Glu Ser Leu Leu Glu Ala Gly Asp Met Leu Gln 
        115                 120                 125             


Phe His Asp Val Arg Asp Ala Ala Ala Glu Phe Leu Glu Lys Asn Leu 
    130                 135                 140                 


Phe Pro Ser Asn Cys Leu Gly Met Met Leu Leu Ser Asp Ala His Gln 
145                 150                 155                 160 


Cys Arg Arg Leu Tyr Glu Phe Ser Trp Arg Met Cys Leu Val His Phe 
                165                 170                 175     


Glu Thr Val Arg Gln Ser Glu Asp Phe Asn Ser Leu Ser Lys Asp Thr 
            180                 185                 190         


Leu Leu Asp Leu Ile Ser Ser Asp Glu Leu Glu Thr Glu Asp Glu Arg 
        195                 200                 205             


Val Val Phe Glu Ala Ile Leu Gln Trp Val Lys His Asp Leu Glu Pro 
    210                 215                 220                 


Arg Lys Val His Leu Pro Glu Leu Leu Arg Ser Val Arg Leu Ala Leu 
225                 230                 235                 240 


Leu Pro Ser Asp Cys Leu Gln Glu Ala Val Ser Ser Glu Ala Leu Leu 
                245                 250                 255     


Met Ala Asp Glu Arg Thr Lys Leu Ile Met Asp Glu Ala Leu Arg Cys 
            260                 265                 270         


Lys Thr Arg Ile Leu Gln Asn Asp Gly Val Val Thr Ser Pro Cys Ala 
        275                 280                 285             


Arg Pro Arg Lys Ala Gly His Thr Leu Leu Ile Leu Gly Gly Gln Thr 
    290                 295                 300                 


Phe Met Cys Asp Lys Ile Tyr Gln Val Asp His Lys Ala Lys Glu Ile 
305                 310                 315                 320 


Ile Pro Lys Ala Asp Leu Pro Ser Pro Arg Lys Glu Phe Ser Ala Ser 
                325                 330                 335     


Ala Ile Gly Cys Lys Val Tyr Val Thr Gly Gly Arg Gly Ser Glu Asn 
            340                 345                 350         


Gly Val Ser Lys Asp Val Trp Val Tyr Asp Thr Val His Glu Glu Trp 
        355                 360                 365             


Ser Lys Ala Ala Pro Met Leu Ile Ala Arg Phe Gly His Gly Ser Ala 
    370                 375                 380                 


Glu Leu Glu Asn Cys Leu Tyr Val Val Gly Gly His Thr Ser Leu Ala 
385                 390                 395                 400 


Gly Val Phe Pro Ala Ser Pro Ser Val Ser Leu Lys Gln Val Glu Lys 
                405                 410                 415     


Tyr Asp Pro Gly Ala Asn Lys Trp Met Met Val Ala Pro Leu Arg Asp 
            420                 425                 430         


Gly Val Ser Asn Ala Ala Val Val Ser Ala Lys Leu Lys Leu Phe Val 
        435                 440                 445             


Phe Gly Gly Thr Ser Ile His Arg Asp Met Val Ser Lys Val Gln Cys 
    450                 455                 460                 


Tyr Asp Pro Ser Glu Asn Arg Trp Thr Ile Lys Ala Glu Cys Pro Gln 
465                 470                 475                 480 


Pro Trp Arg Tyr Thr Ala Ala Ala Val Leu Gly Ser Gln Ile Phe Ile 
                485                 490                 495     


Met Gly Gly Asp Thr Glu Phe Thr Ala Ala Ser Ala Tyr Arg Phe Asp 
            500                 505                 510         


Cys Glu Thr Asn Gln Trp Thr Arg Ile Gly Asp Met Thr Ala Lys Arg 
        515                 520                 525             


Met Ser Cys His Ala Leu Ala Ser Gly Asn Lys Leu Tyr Val Val Gly 
    530                 535                 540                 


Gly Tyr Phe Gly Thr Gln Arg Cys Lys Thr Leu Asp Cys Tyr Asp Pro 
545                 550                 555                 560 


Thr Ser Asp Thr Trp Asn Cys Ile Thr Thr Val Pro Tyr Ser Leu Ile 
                565                 570                 575     


Pro Thr Ala Phe Val Ser Thr Trp Lys His Leu Pro Ala 
            580                 585                 


<210>  5952
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL26__Homo_sapiens__NP_060786

<400>  5952

Met Ala Glu Ser Gly Gly Ser Ser Gly Gly Ala Gly Gly Gly Gly Ala 
1               5                   10                  15      


Phe Gly Ala Gly Pro Gly Pro Glu Arg Pro Asn Ser Thr Ala Asp Lys 
            20                  25                  30          


Asn Gly Ala Leu Lys Cys Thr Phe Ser Ala Pro Ser His Ser Thr Ser 
        35                  40                  45              


Leu Leu Gln Gly Leu Ala Thr Leu Arg Ala Gln Gly Gln Leu Leu Asp 
    50                  55                  60                  


Val Val Leu Thr Ile Asn Arg Glu Ala Phe Pro Ala His Lys Val Val 
65                  70                  75                  80  


Leu Ala Ala Cys Ser Asp Tyr Phe Arg Ala Met Phe Thr Gly Gly Met 
                85                  90                  95      


Arg Glu Ala Ser Gln Asp Val Ile Glu Leu Lys Gly Val Ser Ala Arg 
            100                 105                 110         


Gly Leu Arg His Ile Ile Asp Phe Ala Tyr Ser Ala Glu Val Thr Leu 
        115                 120                 125             


Asp Leu Asp Cys Val Gln Asp Val Leu Gly Ala Ala Val Phe Leu Gln 
    130                 135                 140                 


Met Leu Pro Val Val Glu Leu Cys Glu Glu Phe Leu Lys Ala Ala Met 
145                 150                 155                 160 


Ser Val Glu Thr Cys Leu Asn Ile Gly Gln Met Ala Thr Thr Phe Ser 
                165                 170                 175     


Leu Ala Ser Leu Arg Glu Ser Val Asp Ala Phe Thr Phe Arg His Phe 
            180                 185                 190         


Leu Gln Ile Ala Glu Glu Glu Asp Phe Leu Arg Leu Pro Leu Glu Arg 
        195                 200                 205             


Leu Val Phe Phe Leu Gln Ser Asn Arg Leu Gln Ser Cys Ala Glu Ile 
    210                 215                 220                 


Asp Leu Phe Arg Ala Ala Val Arg Trp Leu Gln His Asp Pro Ala Arg 
225                 230                 235                 240 


Arg Pro Arg Ala Ser His Val Leu Cys His Ile Arg Phe Pro Leu Met 
                245                 250                 255     


Gln Ser Ser Glu Leu Val Asp Ser Val Gln Thr Leu Asp Ile Met Val 
            260                 265                 270         


Glu Asp Val Leu Cys Arg Gln Tyr Leu Leu Glu Ala Phe Asn Tyr Gln 
        275                 280                 285             


Val Leu Pro Phe Arg Gln His Glu Met Gln Ser Pro Arg Thr Ala Val 
    290                 295                 300                 


Arg Ser Asp Val Pro Ser Leu Val Thr Phe Gly Gly Thr Pro Tyr Thr 
305                 310                 315                 320 


Asp Ser Asp Arg Ser Val Ser Ser Lys Val Tyr Gln Leu Pro Glu Pro 
                325                 330                 335     


Gly Ala Arg His Phe Arg Glu Leu Thr Glu Met Glu Val Gly Cys Ser 
            340                 345                 350         


His Thr Cys Val Ala Val Leu Asp Asn Phe Val Tyr Val Ala Gly Gly 
        355                 360                 365             


Gln His Leu Gln Tyr Arg Ser Gly Glu Gly Ala Val Asp Ala Cys Tyr 
    370                 375                 380                 


Arg Tyr Asp Pro His Leu Asn Arg Trp Leu Arg Leu Gln Ala Met Gln 
385                 390                 395                 400 


Glu Ser Arg Ile Gln Phe Gln Leu Asn Val Leu Cys Gly Met Val Tyr 
                405                 410                 415     


Ala Thr Gly Gly Arg Asn Arg Ala Gly Ser Leu Ala Ser Val Glu Arg 
            420                 425                 430         


Tyr Cys Pro Arg Arg Asn Glu Trp Gly Tyr Ala Cys Ser Leu Lys Arg 
        435                 440                 445             


Arg Thr Trp Gly His Ala Gly Ala Ala Ser Gly Gly Arg Leu Tyr Ile 
    450                 455                 460                 


Ser Gly Gly Tyr Gly Ile Ser Val Glu Asp Lys Lys Ala Leu His Cys 
465                 470                 475                 480 


Tyr Asp Pro Val Ala Asp Gln Trp Glu Phe Lys Ala Pro Met Ser Glu 
                485                 490                 495     


Pro Arg Val Leu His Ala Met Val Gly Ala Gly Gly Arg Ile Tyr Ala 
            500                 505                 510         


Leu Gly Gly Arg Met Asp His Val Asp Arg Cys Phe Asp Val Leu Ala 
        515                 520                 525             


Val Glu Tyr Tyr Val Pro Glu Thr Asp Gln Trp Thr Ser Val Ser Pro 
    530                 535                 540                 


Met Arg Ala Gly Gln Ser Glu Ala Gly Cys Cys Leu Leu Glu Arg Lys 
545                 550                 555                 560 


Ile Tyr Ile Val Gly Gly Tyr Asn Trp Arg Leu Asn Asn Val Thr Gly 
                565                 570                 575     


Ile Val Gln Val Tyr Asn Thr Asp Thr Asp Glu Trp Glu Arg Asp Leu 
            580                 585                 590         


His Phe Pro Glu Ser Phe Ala Gly Ile Ala Cys Ala Pro Val Leu Leu 
        595                 600                 605             


Pro Arg Ala Gly Thr Arg Arg 
    610                 615 


<210>  5953
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL29__Homo_sapiens__NP_443152

<400>  5953

Met Ser Arg His His Ser Arg Phe Glu Arg Asp Tyr Arg Val Gly Trp 
1               5                   10                  15      


Asp Arg Arg Glu Trp Ser Val Asn Gly Thr His Gly Thr Thr Ser Ile 
            20                  25                  30          


Cys Ser Val Thr Ser Gly Ala Gly Gly Gly Thr Ala Ser Ser Leu Ser 
        35                  40                  45              


Val Arg Pro Gly Leu Leu Pro Leu Pro Val Val Pro Ser Arg Leu Pro 
    50                  55                  60                  


Thr Pro Ala Thr Ala Pro Ala Pro Cys Thr Thr Gly Ser Ser Glu Ala 
65                  70                  75                  80  


Ile Thr Ser Leu Val Ala Ser Ser Ala Ser Ala Val Thr Thr Lys Ala 
                85                  90                  95      


Pro Gly Ile Ser Lys Gly Asp Ser Gln Ser Gln Gly Leu Ala Thr Ser 
            100                 105                 110         


Ile Arg Trp Gly Gln Thr Pro Ile Asn Gln Ser Thr Pro Trp Asp Thr 
        115                 120                 125             


Asp Glu Pro Pro Ser Lys Gln Met Arg Glu Ser Asp Asn Pro Gly Thr 
    130                 135                 140                 


Gly Pro Trp Val Thr Thr Val Ala Ala Gly Asn Gln Pro Thr Leu Ile 
145                 150                 155                 160 


Ala His Ser Tyr Gly Val Ala Gln Pro Pro Thr Phe Ser Pro Ala Val 
                165                 170                 175     


Asn Val Gln Ala Pro Val Ile Gly Val Thr Pro Ser Leu Pro Pro His 
            180                 185                 190         


Val Gly Pro Gln Leu Pro Leu Met Pro Gly His Tyr Ser Leu Pro Gln 
        195                 200                 205             


Pro Pro Ser Gln Pro Leu Ser Ser Val Val Val Asn Met Pro Ala Gln 
    210                 215                 220                 


Ala Leu Tyr Ala Ser Pro Gln Pro Leu Ala Val Ser Thr Leu Pro Gly 
225                 230                 235                 240 


Val Gly Gln Val Ala Arg Pro Gly Pro Thr Ala Val Gly Asn Gly His 
                245                 250                 255     


Met Ala Gly Pro Leu Leu Pro Pro Pro Pro Pro Ala Gln Pro Ser Ala 
            260                 265                 270         


Thr Leu Pro Ser Gly Ala Pro Ala Thr Asn Gly Pro Pro Thr Thr Asp 
        275                 280                 285             


Ser Ala His Gly Leu Gln Met Leu Arg Thr Ile Gly Val Gly Lys Tyr 
    290                 295                 300                 


Glu Phe Thr Asp Pro Gly His Pro Arg Glu Met Leu Lys Glu Leu Asn 
305                 310                 315                 320 


Gln Gln Arg Arg Ala Lys Ala Phe Thr Asp Leu Lys Ile Val Val Glu 
                325                 330                 335     


Gly Arg Glu Phe Glu Val His Gln Asn Val Leu Ala Ser Cys Ser Leu 
            340                 345                 350         


Tyr Phe Lys Asp Leu Ile Gln Arg Ser Val Gln Asp Ser Gly Gln Gly 
        355                 360                 365             


Gly Arg Glu Lys Leu Glu Leu Val Leu Ser Asn Leu Gln Ala Asp Val 
    370                 375                 380                 


Leu Glu Leu Leu Leu Glu Phe Val Tyr Thr Gly Ser Leu Val Ile Asp 
385                 390                 395                 400 


Ser Ala Asn Ala Lys Thr Leu Leu Glu Ala Ala Ser Lys Phe Gln Phe 
                405                 410                 415     


His Thr Phe Cys Lys Val Cys Val Ser Phe Leu Glu Lys Gln Leu Thr 
            420                 425                 430         


Ala Ser Asn Cys Leu Gly Val Leu Ala Met Ala Glu Ala Met Gln Cys 
        435                 440                 445             


Ser Glu Leu Tyr His Met Ala Lys Ala Phe Ala Leu Gln Ile Phe Pro 
    450                 455                 460                 


Glu Val Ala Ala Gln Glu Glu Ile Leu Ser Ile Ser Lys Asp Asp Phe 
465                 470                 475                 480 


Ile Ala Tyr Val Ser Asn Asp Ser Leu Asn Thr Lys Ala Glu Glu Leu 
                485                 490                 495     


Val Tyr Glu Thr Val Ile Lys Trp Ile Lys Lys Asp Pro Ala Thr Arg 
            500                 505                 510         


Thr Gln Tyr Ala Ala Glu Leu Leu Ala Val Val Arg Leu Pro Phe Ile 
        515                 520                 525             


His Pro Ser Tyr Leu Leu Asn Val Val Asp Asn Glu Glu Leu Ile Lys 
    530                 535                 540                 


Ser Ser Glu Ala Cys Arg Asp Leu Val Asn Glu Ala Lys Arg Tyr His 
545                 550                 555                 560 


Met Leu Pro His Ala Arg Gln Glu Met Gln Thr Pro Arg Thr Arg Pro 
                565                 570                 575     


Arg Leu Ser Ala Gly Val Ala Glu Val Ile Val Leu Val Gly Gly Arg 
            580                 585                 590         


Gln Met Val Gly Met Thr Gln Arg Ser Leu Val Ala Val Thr Cys Trp 
        595                 600                 605             


Asn Pro Gln Asn Asn Lys Trp Tyr Pro Leu Ala Ser Leu Pro Phe Tyr 
    610                 615                 620                 


Asp Arg Glu Phe Phe Ser Val Val Ser Ala Gly Asp Asn Ile Tyr Leu 
625                 630                 635                 640 


Ser Gly Gly Met Glu Ser Gly Val Thr Leu Ala Asp Val Trp Cys Tyr 
                645                 650                 655     


Met Ser Leu Leu Asp Asn Trp Asn Leu Val Ser Arg Met Thr Val Pro 
            660                 665                 670         


Arg Cys Arg His Asn Ser Leu Val Tyr Asp Gly Lys Ile Tyr Thr Leu 
        675                 680                 685             


Gly Gly Leu Gly Val Ala Gly Asn Val Asp His Val Glu Arg Tyr Asp 
    690                 695                 700                 


Thr Ile Thr Asn Gln Trp Glu Ala Val Ala Pro Leu Pro Lys Ala Val 
705                 710                 715                 720 


His Ser Ala Ala Ala Thr Val Cys Gly Gly Lys Ile Tyr Val Phe Gly 
                725                 730                 735     


Gly Val Asn Glu Ala Gly Arg Ala Ala Gly Val Leu Gln Ser Tyr Val 
            740                 745                 750         


Pro Gln Thr Asn Thr Trp Ser Phe Ile Glu Ser Pro Met Ile Asp Asn 
        755                 760                 765             


Lys Tyr Ala Pro Ala Val Thr Leu Asn Gly Phe Val Phe Ile Leu Gly 
    770                 775                 780                 


Gly Ala Tyr Ala Arg Ala Thr Thr Ile Tyr Asp Pro Glu Lys Gly Asn 
785                 790                 795                 800 


Ile Lys Ala Gly Pro Asn Met Asn His Ser Arg Gln Phe Cys Ser Ala 
                805                 810                 815     


Val Val Leu Asp Gly Lys Ile Tyr Ala Thr Gly Gly Ile Val Ser Ser 
            820                 825                 830         


Glu Gly Pro Ala Leu Gly Asn Met Glu Ala Tyr Glu Pro Thr Thr Asn 
        835                 840                 845             


Thr Trp Thr Leu Leu Pro His Met Pro Cys Pro Val Phe Arg His Gly 
    850                 855                 860                 


Cys Val Val Ile Lys Lys Tyr Ile Gln Ser Gly 
865                 870                 875 


<210>  5954
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL2__Homo_sapiens__NP_001154993

<400>  5954

Met Val Trp Leu Glu Ala Arg Pro Gln Ile Leu Phe Val Cys Thr Lys 
1               5                   10                  15      


Gln Gly His Gln Lys Pro Leu Asp Ser Lys Asp Asp Asn Thr Glu Lys 
            20                  25                  30          


His Cys Pro Val Thr Val Asn Pro Trp His Met Lys Lys Ala Phe Lys 
        35                  40                  45              


Val Met Asn Glu Leu Arg Ser Gln Asn Leu Leu Cys Asp Val Thr Ile 
    50                  55                  60                  


Val Ala Glu Asp Met Glu Ile Ser Ala His Arg Val Val Leu Ala Ala 
65                  70                  75                  80  


Cys Ser Pro Tyr Phe His Ala Met Phe Thr Gly Glu Met Ser Glu Ser 
                85                  90                  95      


Arg Ala Lys Arg Val Arg Ile Lys Glu Val Asp Gly Trp Thr Leu Arg 
            100                 105                 110         


Met Leu Ile Asp Tyr Val Tyr Thr Ala Glu Ile Gln Val Thr Glu Glu 
        115                 120                 125             


Asn Val Gln Val Leu Leu Pro Ala Ala Gly Leu Leu Gln Leu Gln Asp 
    130                 135                 140                 


Val Lys Lys Thr Cys Cys Glu Phe Leu Glu Ser Gln Leu His Pro Val 
145                 150                 155                 160 


Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp Met His Ala Cys Thr Asp 
                165                 170                 175     


Leu Leu Asn Lys Ala Asn Thr Tyr Ala Glu Gln His Phe Ala Asp Val 
            180                 185                 190         


Val Leu Ser Glu Glu Phe Leu Asn Leu Gly Ile Glu Gln Val Cys Ser 
        195                 200                 205             


Leu Ile Ser Ser Asp Lys Leu Thr Ile Ser Ser Glu Glu Lys Val Phe 
    210                 215                 220                 


Glu Ala Val Ile Ala Trp Val Asn His Asp Lys Asp Val Arg Gln Glu 
225                 230                 235                 240 


Phe Met Ala Arg Leu Met Glu His Val Arg Leu Pro Leu Leu Pro Arg 
                245                 250                 255     


Glu Tyr Leu Val Gln Arg Val Glu Glu Glu Ala Leu Val Lys Asn Ser 
            260                 265                 270         


Ser Ala Cys Lys Asp Tyr Leu Ile Glu Ala Met Lys Tyr His Leu Leu 
        275                 280                 285             


Pro Thr Glu Gln Arg Ile Leu Met Lys Ser Val Arg Thr Arg Leu Arg 
    290                 295                 300                 


Thr Pro Met Asn Leu Pro Lys Leu Met Val Val Val Gly Gly Gln Ala 
305                 310                 315                 320 


Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr Asp Phe Lys Glu Glu Arg 
                325                 330                 335     


Trp His Gln Val Ala Glu Leu Pro Ser Arg Arg Cys Arg Ala Gly Met 
            340                 345                 350         


Val Tyr Met Ala Gly Leu Val Phe Ala Val Gly Gly Phe Asn Gly Ser 
        355                 360                 365             


Leu Arg Val Arg Thr Val Asp Ser Tyr Asp Pro Val Lys Asp Gln Trp 
    370                 375                 380                 


Thr Ser Val Ala Asn Met Arg Asp Arg Arg Ser Thr Leu Gly Ala Ala 
385                 390                 395                 400 


Val Leu Asn Gly Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly Ser Thr 
                405                 410                 415     


Gly Leu Ser Ser Val Glu Ala Tyr Asn Ile Lys Ser Asn Glu Trp Phe 
            420                 425                 430         


His Val Ala Pro Met Asn Thr Arg Arg Ser Ser Val Gly Val Gly Val 
        435                 440                 445             


Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Tyr Asp Gly Ala Ser Arg 
    450                 455                 460                 


Gln Cys Leu Ser Thr Val Glu Cys Tyr Asn Ala Thr Thr Asn Glu Trp 
465                 470                 475                 480 


Thr Tyr Ile Ala Glu Met Ser Thr Arg Arg Ser Gly Ala Gly Val Gly 
                485                 490                 495     


Val Leu Asn Asn Leu Leu Tyr Ala Val Gly Gly His Asp Gly Pro Leu 
            500                 505                 510         


Val Arg Lys Ser Val Glu Val Tyr Asp Pro Thr Thr Asn Ala Trp Arg 
        515                 520                 525             


Gln Val Ala Asp Met Asn Met Cys Arg Arg Asn Ala Gly Val Cys Ala 
    530                 535                 540                 


Val Asn Gly Leu Leu Tyr Val Val Gly Gly Asp Asp Gly Ser Cys Asn 
545                 550                 555                 560 


Leu Ala Ser Val Glu Tyr Tyr Asn Pro Thr Thr Asp Lys Trp Thr Val 
                565                 570                 575     


Val Ser Ser Cys Met Ser Thr Gly Arg Ser Tyr Ala Gly Val Thr Val 
            580                 585                 590         


Ile Asp Lys Pro Leu 
        595         


<210>  5955
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL31__Homo_sapiens__NP_001003760

<400>  5955

Met Ala Pro Lys Lys Lys Ile Val Lys Lys Asn Lys Gly Asp Ile Asn 
1               5                   10                  15      


Glu Met Thr Ile Ile Val Glu Asp Ser Pro Leu Asn Lys Leu Asn Ala 
            20                  25                  30          


Leu Asn Gly Leu Leu Glu Gly Gly Asn Gly Leu Ser Cys Ile Ser Ser 
        35                  40                  45              


Glu Leu Thr Asp Ala Ser Tyr Gly Pro Asn Leu Leu Glu Gly Leu Ser 
    50                  55                  60                  


Lys Met Arg Gln Glu Asn Phe Leu Cys Asp Leu Val Ile Gly Thr Lys 
65                  70                  75                  80  


Thr Lys Ser Phe Asp Val His Lys Ser Val Met Ala Ser Cys Ser Glu 
                85                  90                  95      


Tyr Phe Tyr Asn Ile Leu Lys Lys Asp Pro Ser Ile Gln Arg Val Asp 
            100                 105                 110         


Leu Asn Asp Ile Ser Pro Leu Gly Leu Ala Thr Val Ile Ala Tyr Ala 
        115                 120                 125             


Tyr Thr Gly Lys Leu Thr Leu Ser Leu Tyr Thr Ile Gly Ser Ile Ile 
    130                 135                 140                 


Ser Ala Ala Val Tyr Leu Gln Ile His Thr Leu Val Lys Met Cys Ser 
145                 150                 155                 160 


Asp Phe Leu Ile Arg Glu Met Ser Val Glu Asn Cys Met Tyr Val Val 
                165                 170                 175     


Asn Ile Ala Glu Thr Tyr Ser Leu Lys Asn Ala Lys Ala Ala Ala Gln 
            180                 185                 190         


Lys Phe Ile Arg Asp Asn Phe Leu Glu Phe Ala Glu Ser Asp Gln Phe 
        195                 200                 205             


Met Lys Leu Thr Phe Glu Gln Ile Asn Glu Leu Leu Ile Asp Asp Asp 
    210                 215                 220                 


Leu Gln Leu Pro Ser Glu Ile Val Ala Phe Gln Ile Ala Met Lys Trp 
225                 230                 235                 240 


Leu Glu Phe Asp Gln Lys Arg Val Lys Tyr Ala Ala Asp Leu Leu Ser 
                245                 250                 255     


Asn Ile Arg Phe Gly Thr Ile Ser Ala Gln Asp Leu Val Asn Tyr Val 
            260                 265                 270         


Gln Ser Val Pro Arg Met Met Gln Asp Ala Asp Cys His Arg Leu Leu 
        275                 280                 285             


Val Asp Ala Met Asn Tyr His Leu Leu Pro Tyr His Gln Asn Thr Leu 
    290                 295                 300                 


Gln Ser Arg Arg Thr Arg Ile Arg Gly Gly Cys Arg Val Leu Val Thr 
305                 310                 315                 320 


Val Gly Gly Arg Pro Gly Leu Thr Glu Lys Ser Leu Ser Arg Asp Ile 
                325                 330                 335     


Leu Tyr Arg Asp Pro Glu Asn Gly Trp Ser Lys Leu Thr Glu Met Pro 
            340                 345                 350         


Ala Lys Ser Phe Asn Gln Cys Val Ala Val Met Asp Gly Phe Leu Tyr 
        355                 360                 365             


Val Ala Gly Gly Glu Asp Gln Asn Asp Ala Arg Asn Gln Ala Lys His 
    370                 375                 380                 


Ala Val Ser Asn Phe Cys Arg Tyr Asp Pro Arg Phe Asn Thr Trp Ile 
385                 390                 395                 400 


His Leu Ala Ser Met Asn Gln Lys Arg Thr His Phe Ser Leu Ser Val 
                405                 410                 415     


Phe Asn Gly Leu Val Tyr Ala Ala Gly Gly Arg Asn Ala Glu Gly Ser 
            420                 425                 430         


Leu Ala Ser Leu Glu Cys Tyr Val Pro Ser Thr Asn Gln Trp Gln Pro 
        435                 440                 445             


Lys Thr Pro Leu Glu Val Ala Arg Cys Cys His Ala Ser Ala Val Ala 
    450                 455                 460                 


Asp Gly Arg Val Leu Val Thr Gly Gly Tyr Ile Ala Asn Ala Tyr Ser 
465                 470                 475                 480 


Arg Ser Val Cys Ala Tyr Asp Pro Ala Ser Asp Ser Trp Gln Glu Leu 
                485                 490                 495     


Pro Asn Leu Ser Thr Pro Arg Gly Trp His Cys Ala Val Thr Leu Ser 
            500                 505                 510         


Asp Arg Val Tyr Val Met Gly Gly Ser Gln Leu Gly Pro Arg Gly Glu 
        515                 520                 525             


Arg Val Asp Val Leu Thr Val Glu Cys Tyr Ser Pro Ala Thr Gly Gln 
    530                 535                 540                 


Trp Ser Tyr Ala Ala Pro Leu Gln Val Gly Val Ser Thr Ala Gly Val 
545                 550                 555                 560 


Ser Ala Leu His Gly Arg Ala Tyr Leu Val Gly Gly Trp Asn Glu Gly 
                565                 570                 575     


Glu Lys Lys Tyr Lys Lys Cys Ile Gln Cys Phe Ser Pro Glu Leu Asn 
            580                 585                 590         


Glu Trp Thr Glu Asp Asp Glu Leu Pro Glu Ala Thr Val Gly Val Ser 
        595                 600                 605             


Cys Cys Thr Leu Ser Met Pro Asn Asn Val Thr Arg Glu Ser Arg Ala 
    610                 615                 620                 


Ser Ser Val Ser Ser Val Pro Val Ser Ile 
625                 630                 


<210>  5956
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL35__Homo_sapiens__NP_001034637

<400>  5956

Met Arg Gln Gly His Ala Pro Glu Glu Ser Glu Pro Gly Cys Glu Ala 
1               5                   10                  15      


Pro Cys Ala Gly Pro Cys His Ala Gln Arg Val Leu Gln Ala Leu Asn 
            20                  25                  30          


Ala Tyr Arg Arg Ser Gly Thr Leu Thr Asp Val Val Leu Arg Ala Gly 
        35                  40                  45              


Gly Arg Asp Phe Pro Cys His Arg Ala Ala Leu Ser Ala Gly Ser Ala 
    50                  55                  60                  


Tyr Phe Arg Ser Leu Phe Ala Ala Gly Arg Pro Glu Arg Gly Pro Ala 
65                  70                  75                  80  


Val Val Pro Val Val Pro Val Ala Pro Glu Ala Pro Gly Thr Ser Pro 
                85                  90                  95      


Ala Gly Ala Ala Ala Ala Leu Ala Val Val Leu Asp Tyr Val Tyr Gly 
            100                 105                 110         


Ala Gly Val Arg Leu Arg Ala Glu Asp Glu Ala Ala Ala Val Leu Ala 
        115                 120                 125             


Leu Ala Glu Arg Leu Gly Val Ala Gly Leu Arg Glu Ala Cys Val Arg 
    130                 135                 140                 


Phe Leu Glu Gly Arg Leu Arg Ala Ala Asn Ser Leu Ala Leu Arg Arg 
145                 150                 155                 160 


Val Ala Ala Ala Phe Ser Leu Ala Pro Leu Ala Glu Arg Cys Gly Arg 
                165                 170                 175     


Val Leu Arg Gln Ala Phe Ala Glu Val Ala Arg His Ala Asp Phe Leu 
            180                 185                 190         


Glu Leu Ala Pro Asp Glu Val Val Ala Leu Leu Ala Asp Pro Ala Leu 
        195                 200                 205             


Gly Val Ala Arg Glu Glu Ala Val Phe Glu Ala Ala Met Arg Trp Val 
    210                 215                 220                 


Arg His Asp Ala Pro Ala Arg Arg Gly Gln Leu Arg Arg Leu Leu Glu 
225                 230                 235                 240 


His Val Arg Leu Pro Leu Leu Ala Pro Ala Tyr Phe Leu Glu Lys Val 
                245                 250                 255     


Glu Ala Asp Glu Leu Leu Gln Ala Cys Gly Glu Cys Arg Pro Leu Leu 
            260                 265                 270         


Leu Glu Ala Arg Ala Cys Phe Ile Leu Gly Arg Glu Ala Gly Ala Leu 
        275                 280                 285             


Arg Thr Arg Pro Arg Arg Phe Met Asp Leu Ala Glu Val Ile Val Val 
    290                 295                 300                 


Ile Gly Gly Cys Asp Arg Lys Gly Leu Leu Lys Leu Pro Phe Ala Asp 
305                 310                 315                 320 


Ala Tyr His Pro Glu Ser Gln Arg Trp Thr Pro Leu Pro Ser Leu Pro 
                325                 330                 335     


Gly Tyr Thr Arg Ser Glu Phe Ala Ala Cys Ala Leu Arg Asn Asp Val 
            340                 345                 350         


Tyr Val Ser Gly Gly His Ile Asn Ser His Asp Val Trp Met Phe Ser 
        355                 360                 365             


Ser His Leu His Thr Trp Ile Lys Val Ala Ser Leu His Lys Gly Arg 
    370                 375                 380                 


Trp Arg His Lys Met Ala Val Val Gln Gly Gln Leu Phe Ala Val Gly 
385                 390                 395                 400 


Gly Phe Asp Gly Leu Arg Arg Leu His Ser Val Glu Arg Tyr Asp Pro 
                405                 410                 415     


Phe Ser Asn Thr Trp Ala Ala Ala Ala Pro Leu Pro Glu Ala Val Ser 
            420                 425                 430         


Ser Ala Ala Val Ala Ser Cys Ala Gly Lys Leu Phe Val Ile Gly Gly 
        435                 440                 445             


Ala Arg Gln Gly Gly Val Asn Thr Asp Lys Val Gln Cys Phe Asp Pro 
    450                 455                 460                 


Lys Glu Asp Arg Trp Ser Leu Arg Ser Pro Ala Pro Phe Ser Gln Arg 
465                 470                 475                 480 


Cys Leu Glu Ala Val Ser Leu Glu Asp Thr Ile Tyr Val Met Gly Gly 
                485                 490                 495     


Leu Met Ser Lys Ile Phe Thr Tyr Asp Pro Gly Thr Asp Val Trp Gly 
            500                 505                 510         


Glu Ala Ala Val Leu Pro Ser Pro Val Glu Ser Cys Gly Val Thr Val 
        515                 520                 525             


Cys Asp Gly Lys Val His Ile Leu Gly Gly Arg Asp Asp Arg Gly Glu 
    530                 535                 540                 


Ser Thr Asp Lys Val Phe Thr Phe Asp Pro Ser Ser Gly Gln Val Glu 
545                 550                 555                 560 


Val Gln Pro Ser Leu Gln Arg Cys Thr Ser Ser His Gly Cys Val Thr 
                565                 570                 575     


Ile Ile Gln Ser Leu Gly Arg 
            580             


<210>  5957
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL3__Homo_sapiens__NP_001244123

<400>  5957

Met Gly Lys Ala Phe Lys Val Met Asn Glu Leu Arg Ser Lys Gln Leu 
1               5                   10                  15      


Leu Cys Asp Val Met Ile Val Ala Glu Asp Val Glu Ile Glu Ala His 
            20                  25                  30          


Arg Val Val Leu Ala Ala Cys Ser Pro Tyr Phe Cys Ala Met Phe Thr 
        35                  40                  45              


Gly Asp Met Ser Glu Ser Lys Ala Lys Lys Ile Glu Ile Lys Asp Val 
    50                  55                  60                  


Asp Gly Gln Thr Leu Ser Lys Leu Ile Asp Tyr Ile Tyr Thr Ala Glu 
65                  70                  75                  80  


Ile Glu Val Thr Glu Glu Asn Val Gln Val Leu Leu Pro Ala Ala Ser 
                85                  90                  95      


Leu Leu Gln Leu Met Asp Val Arg Gln Asn Cys Cys Asp Phe Leu Gln 
            100                 105                 110         


Ser Gln Leu His Pro Thr Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp 
        115                 120                 125             


Val His Thr Cys Thr Asp Leu Leu Gln Gln Ala Asn Ala Tyr Ala Glu 
    130                 135                 140                 


Gln His Phe Pro Glu Val Met Leu Gly Glu Glu Phe Leu Ser Leu Ser 
145                 150                 155                 160 


Leu Asp Gln Val Cys Ser Leu Ile Ser Ser Asp Lys Leu Thr Val Ser 
                165                 170                 175     


Ser Glu Glu Lys Val Phe Glu Ala Val Ile Ser Trp Ile Asn Tyr Glu 
            180                 185                 190         


Lys Glu Thr Arg Leu Glu His Met Ala Lys Leu Met Glu His Val Arg 
        195                 200                 205             


Leu Pro Leu Leu Pro Arg Asp Tyr Leu Val Gln Thr Val Glu Glu Glu 
    210                 215                 220                 


Ala Leu Ile Lys Asn Asn Asn Thr Cys Lys Asp Phe Leu Ile Glu Ala 
225                 230                 235                 240 


Met Lys Tyr His Leu Leu Pro Leu Asp Gln Arg Leu Leu Ile Lys Asn 
                245                 250                 255     


Pro Arg Thr Lys Pro Arg Thr Pro Val Ser Leu Pro Lys Val Met Ile 
            260                 265                 270         


Val Val Gly Gly Gln Ala Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr 
        275                 280                 285             


Asp Phe Glu Glu Asp Arg Trp Asp Gln Ile Ala Glu Leu Pro Ser Arg 
    290                 295                 300                 


Arg Cys Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val 
305                 310                 315                 320 


Gly Gly Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Val Tyr Asp 
                325                 330                 335     


Gly Val Lys Asp Gln Trp Thr Ser Ile Ala Ser Met Gln Glu Arg Arg 
            340                 345                 350         


Ser Thr Leu Gly Ala Ala Val Leu Asn Asp Leu Leu Tyr Ala Val Gly 
        355                 360                 365             


Gly Phe Asp Gly Ser Thr Gly Leu Ala Ser Val Glu Ala Tyr Ser Tyr 
    370                 375                 380                 


Lys Thr Asn Glu Trp Phe Phe Val Ala Pro Met Asn Thr Arg Arg Ser 
385                 390                 395                 400 


Ser Val Gly Val Gly Val Val Glu Gly Lys Leu Tyr Ala Val Gly Gly 
                405                 410                 415     


Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser Thr Val Glu Gln Tyr Asn 
            420                 425                 430         


Pro Ala Thr Asn Glu Trp Ile Tyr Val Ala Asp Met Ser Thr Arg Arg 
        435                 440                 445             


Ser Gly Ala Gly Val Gly Val Leu Ser Gly Gln Leu Tyr Ala Thr Gly 
    450                 455                 460                 


Gly His Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro 
465                 470                 475                 480 


Gly Thr Asn Thr Trp Lys Gln Val Ala Asp Met Asn Met Cys Arg Arg 
                485                 490                 495     


Asn Ala Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly 
            500                 505                 510         


Asp Asp Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Val 
        515                 520                 525             


Thr Asp Lys Trp Thr Leu Leu Pro Thr Asn Met Ser Thr Gly Arg Ser 
    530                 535                 540                 


Tyr Ala Gly Val Ala Val Ile His Lys Ser Leu 
545                 550                 555 


<210>  5958
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL40__Homo_sapiens__NP_689606

<400>  5958

Met Ala Leu Gly Leu Glu Gln Ala Glu Glu Gln Arg Leu Tyr Gln Gln 
1               5                   10                  15      


Thr Leu Leu Gln Asp Gly Leu Lys Asp Met Leu Asp His Gly Lys Phe 
            20                  25                  30          


Leu Asp Cys Val Val Arg Ala Gly Glu Arg Glu Phe Pro Cys His Arg 
        35                  40                  45              


Leu Val Leu Ala Ala Cys Ser Pro Tyr Phe Arg Ala Arg Phe Leu Ala 
    50                  55                  60                  


Glu Pro Glu Arg Ala Gly Glu Leu His Leu Glu Glu Val Ser Pro Asp 
65                  70                  75                  80  


Val Val Ala Gln Val Leu His Tyr Leu Tyr Thr Ser Glu Ile Ala Leu 
                85                  90                  95      


Asp Glu Ala Ser Val Gln Asp Leu Phe Ala Ala Ala His Arg Phe Gln 
            100                 105                 110         


Ile Pro Ser Ile Phe Thr Ile Cys Val Ser Phe Leu Gln Lys Arg Leu 
        115                 120                 125             


Cys Leu Ser Asn Cys Leu Ala Val Phe Arg Leu Gly Leu Leu Leu Asp 
    130                 135                 140                 


Cys Ala Arg Leu Ala Val Ala Ala Arg Asp Phe Ile Cys Ala His Phe 
145                 150                 155                 160 


Thr Leu Val Ala Arg Asp Ala Asp Phe Leu Gly Leu Ser Ala Asp Glu 
                165                 170                 175     


Leu Ile Ala Ile Ile Ser Ser Asp Gly Leu Asn Val Glu Lys Glu Glu 
            180                 185                 190         


Ala Val Phe Glu Ala Val Met Arg Trp Ala Gly Ser Gly Asp Ala Glu 
        195                 200                 205             


Ala Gln Ala Glu Arg Gln Arg Ala Leu Pro Thr Val Phe Glu Ser Val 
    210                 215                 220                 


Arg Cys Arg Leu Leu Pro Arg Ala Phe Leu Glu Ser Arg Val Glu Arg 
225                 230                 235                 240 


His Pro Leu Val Arg Ala Gln Pro Glu Leu Leu Arg Lys Val Gln Met 
                245                 250                 255     


Val Lys Asp Ala His Glu Gly Arg Ile Thr Thr Leu Arg Lys Lys Lys 
            260                 265                 270         


Lys Gly Lys Asp Gly Ala Gly Ala Lys Glu Ala Asp Lys Gly Thr Ser 
        275                 280                 285             


Lys Ala Lys Ala Glu Glu Asp Glu Glu Ala Glu Arg Ile Leu Pro Gly 
    290                 295                 300                 


Ile Leu Asn Asp Thr Leu Arg Phe Gly Met Phe Leu Gln Asp Leu Ile 
305                 310                 315                 320 


Phe Met Ile Ser Glu Glu Gly Ala Val Ala Tyr Asp Pro Ala Ala Asn 
                325                 330                 335     


Glu Cys Tyr Cys Ala Ser Leu Ser Asn Gln Val Pro Lys Asn His Val 
            340                 345                 350         


Ser Leu Val Thr Lys Glu Asn Gln Val Phe Val Ala Gly Gly Leu Phe 
        355                 360                 365             


Tyr Asn Glu Asp Asn Lys Glu Asp Pro Met Ser Ala Tyr Phe Leu Gln 
    370                 375                 380                 


Phe Asp His Leu Asp Ser Glu Trp Leu Gly Met Pro Pro Leu Pro Ser 
385                 390                 395                 400 


Pro Arg Cys Leu Phe Gly Leu Gly Glu Ala Leu Asn Ser Ile Tyr Val 
                405                 410                 415     


Val Gly Gly Arg Glu Ile Lys Asp Gly Glu Arg Cys Leu Asp Ser Val 
            420                 425                 430         


Met Cys Tyr Asp Arg Leu Ser Phe Lys Trp Gly Glu Ser Asp Pro Leu 
        435                 440                 445             


Pro Tyr Val Val Tyr Gly His Thr Val Leu Ser His Met Asp Leu Val 
    450                 455                 460                 


Tyr Val Ile Gly Gly Lys Gly Ser Asp Arg Lys Cys Leu Asn Lys Met 
465                 470                 475                 480 


Cys Val Tyr Asp Pro Lys Lys Phe Glu Trp Lys Glu Leu Ala Pro Met 
                485                 490                 495     


Gln Thr Ala Arg Ser Leu Phe Gly Ala Thr Val His Asp Gly Arg Ile 
            500                 505                 510         


Ile Val Ala Ala Gly Val Thr Asp Thr Gly Leu Thr Ser Ser Ala Glu 
        515                 520                 525             


Val Tyr Ser Ile Thr Asp Asn Lys Trp Ala Pro Phe Glu Ala Phe Pro 
    530                 535                 540                 


Gln Glu Arg Ser Ser Leu Ser Leu Val Ser Leu Val Gly Thr Leu Tyr 
545                 550                 555                 560 


Ala Ile Gly Gly Phe Ala Thr Leu Glu Thr Glu Ser Gly Glu Leu Val 
                565                 570                 575     


Pro Thr Glu Leu Asn Asp Ile Trp Arg Tyr Asn Glu Glu Glu Lys Lys 
            580                 585                 590         


Trp Glu Gly Val Leu Arg Glu Ile Ala Tyr Ala Ala Gly Ala Thr Phe 
        595                 600                 605             


Leu Pro Val Arg Leu Asn Val Leu Cys Leu Thr Lys Met 
    610                 615                 620     


<210>  5959
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL41__Homo_sapiens__NP_006054

<400>  5959

Met Asp Ser Gln Arg Glu Leu Ala Glu Glu Leu Arg Leu Tyr Gln Ser 
1               5                   10                  15      


Thr Leu Leu Gln Asp Gly Leu Lys Asp Leu Leu Asp Glu Lys Lys Phe 
            20                  25                  30          


Ile Asp Cys Thr Leu Lys Ala Gly Asp Lys Ser Leu Pro Cys His Arg 
        35                  40                  45              


Leu Ile Leu Ser Ala Cys Ser Pro Tyr Phe Arg Glu Tyr Phe Leu Ser 
    50                  55                  60                  


Glu Ile Asp Glu Ala Lys Lys Lys Glu Val Val Leu Asp Asn Val Asp 
65                  70                  75                  80  


Pro Ala Ile Leu Asp Leu Ile Ile Lys Tyr Leu Tyr Ser Ala Ser Ile 
                85                  90                  95      


Asp Leu Asn Asp Gly Asn Val Gln Asp Ile Phe Ala Leu Ala Ser Arg 
            100                 105                 110         


Phe Gln Ile Pro Ser Val Phe Thr Val Cys Val Ser Tyr Leu Gln Lys 
        115                 120                 125             


Arg Leu Ala Pro Gly Asn Cys Leu Ala Ile Leu Arg Leu Gly Leu Leu 
    130                 135                 140                 


Leu Asp Cys Pro Arg Leu Ala Ile Ser Ala Arg Glu Phe Val Ser Asp 
145                 150                 155                 160 


Arg Phe Val Gln Ile Cys Lys Glu Glu Asp Phe Met Gln Leu Ser Pro 
                165                 170                 175     


Gln Glu Leu Ile Ser Val Ile Ser Asn Asp Ser Leu Asn Val Glu Lys 
            180                 185                 190         


Glu Glu Ala Val Phe Glu Ala Val Met Lys Trp Val Arg Thr Asp Lys 
        195                 200                 205             


Glu Asn Arg Val Lys Asn Leu Ser Glu Val Phe Asp Cys Ile Arg Phe 
    210                 215                 220                 


Arg Leu Met Thr Glu Lys Tyr Phe Lys Asp His Val Glu Lys Asp Asp 
225                 230                 235                 240 


Ile Ile Lys Ser Asn Pro Asp Leu Gln Lys Lys Ile Lys Val Leu Lys 
                245                 250                 255     


Asp Ala Phe Ala Gly Lys Leu Pro Glu Pro Ser Lys Asn Ala Ala Lys 
            260                 265                 270         


Thr Gly Ala Gly Glu Val Asn Gly Asp Val Gly Asp Glu Asp Leu Leu 
        275                 280                 285             


Pro Gly Tyr Leu Asn Asp Ile Pro Arg His Gly Met Phe Val Lys Asp 
    290                 295                 300                 


Leu Ile Leu Leu Val Asn Asp Thr Ala Ala Val Ala Tyr Asp Pro Thr 
305                 310                 315                 320 


Glu Asn Glu Cys Tyr Leu Thr Ala Leu Ala Glu Gln Ile Pro Arg Asn 
                325                 330                 335     


His Ser Ser Ile Val Thr Gln Gln Asn Gln Ile Tyr Val Val Gly Gly 
            340                 345                 350         


Leu Tyr Val Asp Glu Glu Asn Lys Asp Gln Pro Leu Gln Ser Tyr Phe 
        355                 360                 365             


Phe Gln Leu Asp Ser Ile Ala Ser Glu Trp Val Gly Leu Pro Pro Leu 
    370                 375                 380                 


Pro Ser Ala Arg Cys Leu Phe Gly Leu Gly Glu Val Asp Asp Lys Ile 
385                 390                 395                 400 


Tyr Val Val Ala Gly Lys Asp Leu Gln Thr Glu Ala Ser Leu Asp Ser 
                405                 410                 415     


Val Leu Cys Tyr Asp Pro Val Ala Ala Lys Trp Asn Glu Val Lys Lys 
            420                 425                 430         


Leu Pro Ile Lys Val Tyr Gly His Asn Val Ile Ser His Lys Gly Met 
        435                 440                 445             


Ile Tyr Cys Leu Gly Gly Lys Thr Asp Asp Lys Lys Cys Thr Asn Arg 
    450                 455                 460                 


Val Phe Ile Phe Asn Pro Lys Lys Gly Asp Trp Lys Asp Leu Ala Pro 
465                 470                 475                 480 


Met Lys Ile Pro Arg Ser Met Phe Gly Val Ala Val His Lys Gly Lys 
                485                 490                 495     


Ile Val Ile Ala Gly Gly Val Thr Glu Asp Gly Leu Ser Ala Ser Val 
            500                 505                 510         


Glu Ala Phe Asp Leu Thr Thr Asn Lys Trp Asp Val Met Thr Glu Phe 
        515                 520                 525             


Pro Gln Glu Arg Ser Ser Ile Ser Leu Val Ser Leu Ala Gly Ser Leu 
    530                 535                 540                 


Tyr Ala Ile Gly Gly Phe Ala Met Ile Gln Leu Glu Ser Lys Glu Phe 
545                 550                 555                 560 


Ala Pro Thr Glu Val Asn Asp Ile Trp Lys Tyr Glu Asp Asp Lys Lys 
                565                 570                 575     


Glu Trp Ala Gly Met Leu Lys Glu Ile Arg Tyr Ala Ser Gly Ala Ser 
            580                 585                 590         


Cys Leu Ala Thr Arg Leu Asn Leu Phe Lys Leu Ser Lys Leu 
        595                 600                 605     


<210>  5960
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL42__Homo_sapiens__NP_065833

<400>  5960

Met Ser Ala Glu Glu Met Val Gln Ile Arg Leu Glu Asp Arg Cys Tyr 
1               5                   10                  15      


Pro Val Ser Lys Arg Lys Leu Ile Glu Gln Ser Asp Tyr Phe Arg Ala 
            20                  25                  30          


Leu Tyr Arg Ser Gly Met Arg Glu Ala Leu Ser Gln Glu Ala Gly Gly 
        35                  40                  45              


Pro Glu Val Gln Gln Leu Arg Gly Leu Ser Ala Pro Gly Leu Arg Leu 
    50                  55                  60                  


Val Leu Asp Phe Ile Asn Ala Gly Gly Ala Arg Glu Gly Trp Leu Leu 
65                  70                  75                  80  


Gly Pro Arg Gly Glu Lys Gly Gly Gly Val Asp Glu Asp Glu Glu Met 
                85                  90                  95      


Asp Glu Val Ser Leu Leu Ser Glu Leu Val Glu Ala Ala Ser Phe Leu 
            100                 105                 110         


Gln Val Thr Ser Leu Leu Gln Leu Leu Leu Ser Gln Val Arg Leu Asn 
        115                 120                 125             


Asn Cys Leu Glu Met Tyr Arg Leu Ala Gln Val Tyr Gly Leu Pro Asp 
    130                 135                 140                 


Leu Gln Glu Ala Cys Leu Arg Phe Met Val Val His Phe His Glu Val 
145                 150                 155                 160 


Leu Cys Lys Pro Gln Phe His Leu Leu Gly Ser Pro Pro Gln Ala Pro 
                165                 170                 175     


Gly Asp Val Ser Leu Lys Gln Arg Leu Arg Glu Ala Arg Met Thr Gly 
            180                 185                 190         


Thr Pro Val Leu Val Ala Leu Gly Asp Phe Leu Gly Gly Pro Leu Ala 
        195                 200                 205             


Pro His Pro Tyr Gln Gly Glu Pro Pro Ser Met Leu Arg Tyr Glu Glu 
    210                 215                 220                 


Met Thr Glu Arg Trp Phe Pro Leu Ala Asn Asn Leu Pro Pro Asp Leu 
225                 230                 235                 240 


Val Asn Val Arg Gly Tyr Gly Ser Ala Ile Leu Asp Asn Tyr Leu Phe 
                245                 250                 255     


Ile Val Gly Gly Tyr Arg Ile Thr Ser Gln Glu Ile Ser Ala Ala His 
            260                 265                 270         


Ser Tyr Asn Pro Ser Thr Asn Glu Trp Leu Gln Val Ala Ser Met Asn 
        275                 280                 285             


Gln Lys Arg Ser Asn Phe Lys Leu Val Ala Val Asn Ser Lys Leu Tyr 
    290                 295                 300                 


Ala Ile Gly Gly Gln Ala Val Ser Asn Val Glu Cys Tyr Asn Pro Glu 
305                 310                 315                 320 


Gln Asp Ala Trp Asn Phe Val Ala Pro Leu Pro Asn Pro Leu Ala Glu 
                325                 330                 335     


Phe Ser Ala Cys Glu Cys Lys Gly Lys Ile Tyr Val Ile Gly Gly Tyr 
            340                 345                 350         


Thr Thr Arg Asp Arg Asn Met Asn Ile Leu Gln Tyr Cys Pro Ser Ser 
        355                 360                 365             


Asp Met Trp Thr Leu Phe Glu Thr Cys Asp Val His Ile Arg Lys Gln 
    370                 375                 380                 


Gln Met Val Ser Val Glu Glu Thr Ile Tyr Ile Val Gly Gly Cys Leu 
385                 390                 395                 400 


His Glu Leu Gly Pro Asn Arg Arg Ser Ser Gln Ser Glu Asp Met Leu 
                405                 410                 415     


Thr Val Gln Ser Tyr Asn Thr Val Thr Arg Gln Trp Leu Tyr Leu Lys 
            420                 425                 430         


Glu Asn Thr Ser Lys Ser Gly Leu Asn Leu Thr Cys Ala Leu His Asn 
        435                 440                 445             


Asp Gly Ile Tyr Ile Met Ser Arg Asp Val Thr Leu Ser Thr Ser Leu 
    450                 455                 460                 


Glu His Arg Val Phe Leu Lys Tyr Asn Ile Phe Ser Asp Ser Trp Glu 
465                 470                 475                 480 


Ala Phe Arg Arg Phe Pro Ala Phe Gly His Asn Leu Leu Val Ser Ser 
                485                 490                 495     


Leu Tyr Leu Pro Asn Lys Ala Glu Thr 
            500                 505 


<210>  5961
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL5__Homo_sapiens__NP_001007076

<400>  5961

Met Ser Gly Ser Arg Lys Glu Phe Asp Val Lys Gln Ile Leu Lys Ile 
1               5                   10                  15      


Arg Trp Arg Trp Phe Gly His Gln Ala Ser Ser Pro Asn Ser Thr Val 
            20                  25                  30          


Asp Ser Gln Gln Gly Glu Phe Trp Asn Arg Gly Gln Thr Gly Ala Asn 
        35                  40                  45              


Gly Gly Arg Lys Phe Leu Asp Pro Cys Ser Leu Gln Leu Pro Leu Ala 
    50                  55                  60                  


Ser Ile Gly Tyr Arg Arg Ser Ser Gln Leu Asp Phe Gln Asn Ser Pro 
65                  70                  75                  80  


Ser Trp Pro Met Ala Ser Thr Ser Glu Val Pro Ala Phe Glu Phe Thr 
                85                  90                  95      


Ala Glu Asp Cys Gly Gly Ala His Trp Leu Asp Arg Pro Glu Val Asp 
            100                 105                 110         


Asp Gly Thr Ser Glu Glu Glu Asn Glu Ser Asp Ser Ser Ser Cys Arg 
        115                 120                 125             


Thr Ser Asn Ser Ser Gln Thr Leu Ser Ser Cys His Thr Met Glu Pro 
    130                 135                 140                 


Cys Thr Ser Asp Glu Phe Phe Gln Ala Leu Asn His Ala Glu Gln Thr 
145                 150                 155                 160 


Phe Lys Lys Met Glu Asn Tyr Leu Arg His Lys Gln Leu Cys Asp Val 
                165                 170                 175     


Ile Leu Val Ala Gly Asp Arg Arg Ile Pro Ala His Arg Leu Val Leu 
            180                 185                 190         


Ser Ser Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn Asp Val Arg 
        195                 200                 205             


Glu Ala Arg Gln Glu Glu Ile Lys Met Glu Gly Val Glu Pro Asn Ser 
    210                 215                 220                 


Leu Trp Ser Leu Ile Gln Tyr Ala Tyr Thr Gly Arg Leu Glu Leu Lys 
225                 230                 235                 240 


Glu Asp Asn Ile Glu Cys Leu Leu Ser Thr Ala Cys Leu Leu Gln Leu 
                245                 250                 255     


Ser Gln Val Val Glu Ala Cys Cys Lys Phe Leu Met Lys Gln Leu His 
            260                 265                 270         


Pro Ser Asn Cys Leu Gly Ile Arg Ser Phe Ala Asp Ala Gln Gly Cys 
        275                 280                 285             


Thr Asp Leu His Lys Val Ala His Asn Tyr Thr Met Glu His Phe Met 
    290                 295                 300                 


Glu Val Ile Arg Asn Gln Glu Phe Val Leu Leu Pro Ala Ser Glu Ile 
305                 310                 315                 320 


Ala Lys Leu Leu Ala Ser Asp Asp Met Asn Ile Pro Asn Glu Glu Thr 
                325                 330                 335     


Ile Leu Asn Ala Leu Leu Thr Trp Val Arg His Asp Leu Glu Gln Arg 
            340                 345                 350         


Arg Lys Asp Leu Ser Lys Leu Leu Ala Tyr Ile Arg Leu Pro Leu Leu 
        355                 360                 365             


Ala Pro Gln Phe Leu Ala Asp Met Glu Asn Asn Val Leu Phe Arg Asp 
    370                 375                 380                 


Asp Ile Glu Cys Gln Lys Leu Ile Met Glu Ala Met Lys Tyr His Leu 
385                 390                 395                 400 


Leu Pro Glu Arg Arg Pro Met Leu Gln Ser Pro Arg Thr Lys Pro Arg 
                405                 410                 415     


Lys Ser Thr Val Gly Thr Leu Phe Ala Val Gly Gly Met Asp Ser Thr 
            420                 425                 430         


Lys Gly Ala Thr Ser Ile Glu Lys Tyr Asp Leu Arg Thr Asn Met Trp 
        435                 440                 445             


Thr Pro Val Ala Asn Met Asn Gly Arg Arg Leu Gln Phe Gly Val Ala 
    450                 455                 460                 


Val Leu Asp Asp Lys Leu Tyr Val Val Gly Gly Arg Asp Gly Leu Lys 
465                 470                 475                 480 


Thr Leu Asn Thr Val Glu Cys Tyr Asn Pro Lys Thr Lys Thr Trp Ser 
                485                 490                 495     


Val Met Pro Pro Met Ser Thr His Arg His Gly Leu Gly Val Ala Val 
            500                 505                 510         


Leu Glu Gly Pro Met Tyr Ala Val Gly Gly His Asp Gly Trp Ser Tyr 
        515                 520                 525             


Leu Asn Thr Val Glu Arg Trp Asp Pro Gln Ala Arg Gln Trp Asn Phe 
    530                 535                 540                 


Val Ala Thr Met Ser Thr Pro Arg Ser Thr Val Gly Val Ala Val Leu 
545                 550                 555                 560 


Ser Gly Lys Leu Tyr Ala Val Gly Gly Arg Asp Gly Ser Ser Cys Leu 
                565                 570                 575     


Lys Ser Val Glu Cys Phe Asp Pro His Thr Asn Lys Trp Thr Leu Cys 
            580                 585                 590         


Ala Gln Met Ser Lys Arg Arg Gly Gly Val Gly Val Thr Thr Trp Asn 
        595                 600                 605             


Gly Leu Leu Tyr Ala Ile Gly Gly His Asp Ala Pro Ala Ser Asn Leu 
    610                 615                 620                 


Thr Ser Arg Leu Ser Asp Cys Val Glu Arg Tyr Asp Pro Lys Thr Asp 
625                 630                 635                 640 


Met Trp Thr Ala Val Ala Ser Met Ser Ile Ser Arg Asp Ala Val Gly 
                645                 650                 655     


Val Cys Leu Leu Gly Asp Lys Leu Tyr Ala Val Gly Gly Tyr Asp Gly 
            660                 665                 670         


Gln Ala Tyr Leu Asn Thr Val Glu Ala Tyr Asp Pro Gln Thr Asn Glu 
        675                 680                 685             


Trp Thr Gln Val Ala Pro Leu Cys Leu Gly Arg Ala Gly Ala Cys Val 
    690                 695                 700                 


Val Thr Val Lys Leu 
705                 


<210>  5962
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL6__Homo_sapiens__NP_569713

<400>  5962

Met Leu Met Ala Gly Gln Arg Gly Ala Trp Thr Met Gly Asp Val Val 
1               5                   10                  15      


Glu Lys Ser Leu Glu Gly Pro Leu Ala Pro Ser Thr Asp Glu Pro Ser 
            20                  25                  30          


Gln Lys Thr Gly Asp Leu Val Glu Ile Leu Asn Gly Glu Lys Val Lys 
        35                  40                  45              


Phe Asp Asp Ala Gly Leu Ser Leu Ile Leu Gln Asn Gly Leu Glu Thr 
    50                  55                  60                  


Leu Arg Met Glu Asn Ala Leu Thr Asp Val Ile Leu Cys Val Asp Ile 
65                  70                  75                  80  


Gln Glu Phe Ser Cys His Arg Val Val Leu Ala Ala Ala Ser Asn Tyr 
                85                  90                  95      


Phe Arg Ala Met Phe Cys Asn Asp Leu Lys Glu Lys Tyr Glu Lys Arg 
            100                 105                 110         


Ile Ile Ile Lys Gly Val Asp Ala Glu Thr Met His Thr Leu Leu Asp 
        115                 120                 125             


Tyr Thr Tyr Thr Ser Lys Ala Leu Ile Thr Lys Gln Asn Val Gln Arg 
    130                 135                 140                 


Val Leu Glu Ala Ala Asn Leu Phe Gln Phe Leu Arg Met Val Asp Ala 
145                 150                 155                 160 


Cys Ala Ser Phe Leu Thr Glu Ala Leu Asn Pro Glu Asn Cys Val Gly 
                165                 170                 175     


Ile Leu Arg Leu Ala Asp Thr His Ser Leu Asp Ser Leu Lys Lys Gln 
            180                 185                 190         


Val Gln Ser Tyr Ile Ile Gln Asn Phe Val Gln Ile Leu Asn Ser Glu 
        195                 200                 205             


Glu Phe Leu Asp Leu Pro Val Asp Thr Leu His His Ile Leu Lys Ser 
    210                 215                 220                 


Asp Asp Leu Tyr Val Thr Glu Glu Ala Gln Val Phe Glu Thr Val Met 
225                 230                 235                 240 


Ser Trp Val Arg His Lys Pro Ser Glu Arg Leu Cys Leu Leu Pro Tyr 
                245                 250                 255     


Val Leu Glu Asn Val Arg Leu Pro Leu Leu Asp Pro Trp Tyr Phe Val 
            260                 265                 270         


Glu Thr Val Glu Ala Asp Pro Leu Ile Arg Gln Cys Pro Glu Val Phe 
        275                 280                 285             


Pro Leu Leu Gln Glu Ala Arg Met Tyr His Leu Ser Gly Asn Glu Ile 
    290                 295                 300                 


Ile Ser Glu Arg Thr Lys Pro Arg Met His Glu Phe Gln Ser Glu Val 
305                 310                 315                 320 


Phe Met Ile Ile Gly Gly Cys Thr Lys Asp Glu Arg Phe Val Ala Glu 
                325                 330                 335     


Val Thr Cys Leu Asp Pro Leu Arg Arg Ser Arg Leu Glu Val Ala Lys 
            340                 345                 350         


Leu Pro Leu Thr Glu His Glu Leu Glu Ser Glu Asn Lys Lys Trp Val 
        355                 360                 365             


Glu Phe Ala Cys Val Thr Leu Lys Asn Glu Val Tyr Ile Ser Gly Gly 
    370                 375                 380                 


Lys Glu Thr Gln His Asp Val Trp Lys Tyr Asn Ser Ser Ile Asn Lys 
385                 390                 395                 400 


Trp Ile Gln Ile Glu Tyr Leu Asn Ile Gly Arg Trp Arg His Lys Met 
                405                 410                 415     


Val Val Leu Gly Gly Lys Val Tyr Val Ile Gly Gly Phe Asp Gly Leu 
            420                 425                 430         


Gln Arg Ile Asn Asn Val Glu Thr Tyr Asp Pro Phe His Asn Cys Trp 
        435                 440                 445             


Ser Glu Ala Ala Pro Leu Leu Val His Val Ser Ser Phe Ala Ala Thr 
    450                 455                 460                 


Ser His Lys Lys Lys Leu Tyr Val Ile Gly Gly Gly Pro Asn Gly Lys 
465                 470                 475                 480 


Leu Ala Thr Asp Lys Thr Gln Cys Tyr Asp Pro Ser Thr Asn Lys Trp 
                485                 490                 495     


Ser Leu Lys Ala Ala Met Pro Val Glu Ala Lys Cys Ile Asn Ala Val 
            500                 505                 510         


Ser Phe Arg Asp Arg Ile Tyr Val Val Gly Gly Ala Met Arg Ala Leu 
        515                 520                 525             


Tyr Ala Tyr Ser Pro Leu Glu Asp Ser Trp Cys Leu Val Thr Gln Leu 
    530                 535                 540                 


Ser His Glu Arg Ala Ser Cys Gly Ile Ala Pro Cys Asn Asn Arg Leu 
545                 550                 555                 560 


Tyr Ile Thr Gly Gly Arg Asp Glu Lys Asn Glu Val Ile Ala Thr Val 
                565                 570                 575     


Leu Cys Trp Asp Pro Glu Ala Gln Lys Leu Thr Glu Glu Cys Val Leu 
            580                 585                 590         


Pro Arg Gly Val Ser His His Gly Ser Val Thr Ile Arg Lys Ser Tyr 
        595                 600                 605             


Thr His Ile Arg Arg Ile Val Pro Gly Ala Val Ser Val 
    610                 615                 620     


<210>  5963
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL7__Homo_sapiens__NP_001026880

<400>  5963

Met Ala Ala Ser Gly Val Glu Lys Ser Ser Lys Lys Lys Thr Glu Lys 
1               5                   10                  15      


Lys Leu Ala Ala Arg Glu Glu Ala Lys Leu Leu Ala Gly Phe Met Gly 
            20                  25                  30          


Val Met Asn Asn Met Arg Lys Gln Lys Thr Leu Cys Asp Val Ile Leu 
        35                  40                  45              


Met Val Gln Glu Arg Lys Ile Pro Ala His Arg Val Val Leu Ala Ala 
    50                  55                  60                  


Ala Ser His Phe Phe Asn Leu Met Phe Thr Thr Asn Met Leu Glu Ser 
65                  70                  75                  80  


Lys Ser Phe Glu Val Glu Leu Lys Asp Ala Glu Pro Asp Ile Ile Glu 
                85                  90                  95      


Gln Leu Val Glu Phe Ala Tyr Thr Ala Arg Ile Ser Val Asn Ser Asn 
            100                 105                 110         


Asn Val Gln Ser Leu Leu Asp Ala Ala Asn Gln Tyr Gln Ile Glu Pro 
        115                 120                 125             


Val Lys Lys Met Cys Val Asp Phe Leu Lys Glu Gln Val Asp Ala Ser 
    130                 135                 140                 


Asn Cys Leu Gly Ile Ser Val Leu Ala Glu Cys Leu Asp Cys Pro Glu 
145                 150                 155                 160 


Leu Lys Ala Thr Ala Asp Asp Phe Ile His Gln His Phe Thr Glu Val 
                165                 170                 175     


Tyr Lys Thr Asp Glu Phe Leu Gln Leu Asp Val Lys Arg Val Thr His 
            180                 185                 190         


Leu Leu Asn Gln Asp Thr Leu Thr Val Arg Ala Glu Asp Gln Val Tyr 
        195                 200                 205             


Asp Ala Ala Val Arg Trp Leu Lys Tyr Asp Glu Pro Asn Arg Gln Pro 
    210                 215                 220                 


Phe Met Val Asp Ile Leu Ala Lys Val Arg Phe Pro Leu Ile Ser Lys 
225                 230                 235                 240 


Asn Phe Leu Ser Lys Thr Val Gln Ala Glu Pro Leu Ile Gln Asp Asn 
                245                 250                 255     


Pro Glu Cys Leu Lys Met Val Ile Ser Gly Met Arg Tyr His Leu Leu 
            260                 265                 270         


Ser Pro Glu Asp Arg Glu Glu Leu Val Asp Gly Thr Arg Pro Arg Arg 
        275                 280                 285             


Lys Lys His Asp Tyr Arg Ile Ala Leu Phe Gly Gly Ser Gln Pro Gln 
    290                 295                 300                 


Ser Cys Arg Tyr Phe Asn Pro Lys Asp Tyr Ser Trp Thr Asp Ile Arg 
305                 310                 315                 320 


Cys Pro Phe Glu Lys Arg Arg Asp Ala Ala Cys Val Phe Trp Asp Asn 
                325                 330                 335     


Val Val Tyr Ile Leu Gly Gly Ser Gln Leu Phe Pro Ile Lys Arg Met 
            340                 345                 350         


Asp Cys Tyr Asn Val Val Lys Asp Ser Trp Tyr Ser Lys Leu Gly Pro 
        355                 360                 365             


Pro Thr Pro Arg Asp Ser Leu Ala Ala Cys Ala Ala Glu Gly Lys Ile 
    370                 375                 380                 


Tyr Thr Ser Gly Gly Ser Glu Val Gly Asn Ser Ala Leu Tyr Leu Phe 
385                 390                 395                 400 


Glu Cys Tyr Asp Thr Arg Thr Glu Ser Trp His Thr Lys Pro Ser Met 
                405                 410                 415     


Leu Thr Gln Arg Cys Ser His Gly Met Val Glu Ala Asn Gly Leu Ile 
            420                 425                 430         


Tyr Val Cys Gly Gly Ser Leu Gly Asn Asn Val Ser Gly Arg Val Leu 
        435                 440                 445             


Asn Ser Cys Glu Val Tyr Asp Pro Ala Thr Glu Thr Trp Thr Glu Leu 
    450                 455                 460                 


Cys Pro Met Ile Glu Ala Arg Lys Asn His Gly Leu Val Phe Val Lys 
465                 470                 475                 480 


Asp Lys Ile Phe Ala Val Gly Gly Gln Asn Gly Leu Gly Gly Leu Asp 
                485                 490                 495     


Asn Val Glu Tyr Tyr Asp Ile Lys Leu Asn Glu Trp Lys Met Val Ser 
            500                 505                 510         


Pro Met Pro Trp Lys Gly Val Thr Val Lys Cys Ala Ala Val Gly Ser 
        515                 520                 525             


Ile Val Tyr Val Leu Ala Gly Phe Gln Gly Val Gly Arg Leu Gly His 
    530                 535                 540                 


Ile Leu Glu Tyr Asn Thr Glu Thr Asp Lys Trp Val Ala Asn Ser Lys 
545                 550                 555                 560 


Val Arg Ala Phe Pro Val Thr Ser Cys Leu Ile Cys Val Val Asp Thr 
                565                 570                 575     


Cys Gly Ala Asn Glu Glu Thr Leu Glu Thr 
            580                 585     


<210>  5964
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLHL9__Homo_sapiens__NP_061335

<400>  5964

Met Lys Val Ser Leu Gly Asn Gly Glu Met Gly Val Ser Ala His Leu 
1               5                   10                  15      


Gln Pro Cys Lys Ala Gly Thr Thr Arg Phe Phe Thr Ser Asn Thr His 
            20                  25                  30          


Ser Ser Val Val Leu Gln Gly Phe Asp Gln Leu Arg Ile Glu Gly Leu 
        35                  40                  45              


Leu Cys Asp Val Thr Leu Val Pro Gly Asp Gly Asp Glu Ile Phe Pro 
    50                  55                  60                  


Val His Arg Ala Met Met Ala Ser Ala Ser Asp Tyr Phe Lys Ala Met 
65                  70                  75                  80  


Phe Thr Gly Gly Met Lys Glu Gln Asp Leu Met Cys Ile Lys Leu His 
                85                  90                  95      


Gly Val Asn Lys Val Gly Leu Lys Lys Ile Ile Asp Phe Ile Tyr Thr 
            100                 105                 110         


Ala Lys Leu Ser Leu Asn Met Asp Asn Leu Gln Asp Thr Leu Glu Ala 
        115                 120                 125             


Ala Ser Phe Leu Gln Ile Leu Pro Val Leu Asp Phe Cys Lys Val Phe 
    130                 135                 140                 


Leu Ile Ser Gly Val Ser Leu Asp Asn Cys Val Glu Val Gly Arg Ile 
145                 150                 155                 160 


Ala Asn Thr Tyr Asn Leu Ile Glu Val Asp Lys Tyr Val Asn Asn Phe 
                165                 170                 175     


Ile Leu Lys Asn Phe Pro Ala Leu Leu Ser Thr Gly Glu Phe Leu Lys 
            180                 185                 190         


Leu Pro Phe Glu Arg Leu Ala Phe Val Leu Ser Ser Asn Ser Leu Lys 
        195                 200                 205             


His Cys Thr Glu Leu Glu Leu Phe Lys Ala Ala Cys Arg Trp Leu Arg 
    210                 215                 220                 


Leu Glu Asp Pro Arg Met Asp Tyr Ala Ala Lys Leu Met Lys Asn Ile 
225                 230                 235                 240 


Arg Phe Pro Leu Met Thr Pro Gln Asp Leu Ile Asn Tyr Val Gln Thr 
                245                 250                 255     


Val Asp Phe Met Arg Thr Asp Asn Thr Cys Val Asn Leu Leu Leu Glu 
            260                 265                 270         


Ala Ser Asn Tyr Gln Met Met Pro Tyr Met Gln Pro Val Met Gln Ser 
        275                 280                 285             


Asp Arg Thr Ala Ile Arg Ser Asp Ser Thr His Leu Val Thr Leu Gly 
    290                 295                 300                 


Gly Val Leu Arg Gln Gln Leu Val Val Ser Lys Glu Leu Arg Met Tyr 
305                 310                 315                 320 


Asp Glu Arg Ala Gln Glu Trp Arg Ser Leu Ala Pro Met Asp Ala Pro 
                325                 330                 335     


Arg Tyr Gln His Gly Ile Ala Val Ile Gly Asn Phe Leu Tyr Val Val 
            340                 345                 350         


Gly Gly Gln Ser Asn Tyr Asp Thr Lys Gly Lys Thr Ala Val Asp Thr 
        355                 360                 365             


Val Phe Arg Phe Asp Pro Arg Tyr Asn Lys Trp Met Gln Val Ala Ser 
    370                 375                 380                 


Leu Asn Glu Lys Arg Thr Phe Phe His Leu Ser Ala Leu Lys Gly His 
385                 390                 395                 400 


Leu Tyr Ala Val Gly Gly Arg Ser Ala Ala Gly Glu Leu Ala Thr Val 
                405                 410                 415     


Glu Cys Tyr Asn Pro Arg Met Asn Glu Trp Ser Tyr Val Ala Lys Met 
            420                 425                 430         


Ser Glu Pro His Tyr Gly His Ala Gly Thr Val Tyr Gly Gly Leu Met 
        435                 440                 445             


Tyr Ile Ser Gly Gly Ile Thr His Asp Thr Phe Gln Asn Glu Leu Met 
    450                 455                 460                 


Cys Phe Asp Pro Asp Thr Asp Lys Trp Met Gln Lys Ala Pro Met Thr 
465                 470                 475                 480 


Thr Val Arg Gly Leu His Cys Met Cys Thr Val Gly Asp Lys Leu Tyr 
                485                 490                 495     


Val Ile Gly Gly Asn His Phe Arg Gly Thr Ser Asp Tyr Asp Asp Val 
            500                 505                 510         


Leu Ser Cys Glu Tyr Tyr Ser Pro Thr Leu Asp Gln Trp Thr Pro Ile 
        515                 520                 525             


Ala Ala Met Leu Arg Gly Gln Ser Asp Val Gly Val Ala Val Phe Glu 
    530                 535                 540                 


Asn Lys Ile Tyr Val Val Gly Gly Tyr Ser Trp Asn Asn Arg Cys Met 
545                 550                 555                 560 


Val Glu Ile Val Gln Lys Tyr Asp Pro Glu Lys Asp Glu Trp His Lys 
                565                 570                 575     


Val Phe Asp Leu Pro Glu Ser Leu Gly Gly Ile Arg Ala Cys Thr Leu 
            580                 585                 590         


Thr Val Phe Pro Pro Glu Glu Asn Pro Gly Ser Pro Ser Arg Glu Ser 
        595                 600                 605             


Pro Leu Ser Ala Pro Ser Asp His Ser 
    610                 615         


<210>  5965
<211>  1012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KL__Homo_sapiens__NP_004786

<400>  5965

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  5966
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK10__Homo_sapiens__NP_002767

<400>  5966

Met Arg Ala Pro His Leu His Leu Ser Ala Ala Ser Gly Ala Arg Ala 
1               5                   10                  15      


Leu Ala Lys Leu Leu Pro Leu Leu Met Ala Gln Leu Trp Ala Ala Glu 
            20                  25                  30          


Ala Ala Leu Leu Pro Gln Asn Asp Thr Arg Leu Asp Pro Glu Ala Tyr 
        35                  40                  45              


Gly Ser Pro Cys Ala Arg Gly Ser Gln Pro Trp Gln Val Ser Leu Phe 
    50                  55                  60                  


Asn Gly Leu Ser Phe His Cys Ala Gly Val Leu Val Asp Gln Ser Trp 
65                  70                  75                  80  


Val Leu Thr Ala Ala His Cys Gly Asn Lys Pro Leu Trp Ala Arg Val 
                85                  90                  95      


Gly Asp Asp His Leu Leu Leu Leu Gln Gly Glu Gln Leu Arg Arg Thr 
            100                 105                 110         


Thr Arg Ser Val Val His Pro Lys Tyr His Gln Gly Ser Gly Pro Ile 
        115                 120                 125             


Leu Pro Arg Arg Thr Asp Glu His Asp Leu Met Leu Leu Lys Leu Ala 
    130                 135                 140                 


Arg Pro Val Val Leu Gly Pro Arg Val Arg Ala Leu Gln Leu Pro Tyr 
145                 150                 155                 160 


Arg Cys Ala Gln Pro Gly Asp Gln Cys Gln Val Ala Gly Trp Gly Thr 
                165                 170                 175     


Thr Ala Ala Arg Arg Val Lys Tyr Asn Lys Gly Leu Thr Cys Ser Ser 
            180                 185                 190         


Ile Thr Ile Leu Ser Pro Lys Glu Cys Glu Val Phe Tyr Pro Gly Val 
        195                 200                 205             


Val Thr Asn Asn Met Ile Cys Ala Gly Leu Asp Arg Gly Gln Asp Pro 
    210                 215                 220                 


Cys Gln Ser Asp Ser Gly Gly Pro Leu Val Cys Asp Glu Thr Leu Gln 
225                 230                 235                 240 


Gly Ile Leu Ser Trp Gly Val Tyr Pro Cys Gly Ser Ala Gln His Pro 
                245                 250                 255     


Ala Val Tyr Thr Gln Ile Cys Lys Tyr Met Ser Trp Ile Asn Lys Val 
            260                 265                 270         


Ile Arg Ser Asn 
        275     


<210>  5967
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK11__Homo_sapiens__NP_001129504

<400>  5967

Met Arg Ile Leu Gln Leu Ile Leu Leu Ala Leu Ala Thr Gly Leu Val 
1               5                   10                  15      


Gly Gly Glu Thr Arg Ile Ile Lys Gly Phe Glu Cys Lys Pro His Ser 
            20                  25                  30          


Gln Pro Trp Gln Ala Ala Leu Phe Glu Lys Thr Arg Leu Leu Cys Gly 
        35                  40                  45              


Ala Thr Leu Ile Ala Pro Arg Trp Leu Leu Thr Ala Ala His Cys Leu 
    50                  55                  60                  


Lys Pro Arg Tyr Ile Val His Leu Gly Gln His Asn Leu Gln Lys Glu 
65                  70                  75                  80  


Glu Gly Cys Glu Gln Thr Arg Thr Ala Thr Glu Ser Phe Pro His Pro 
                85                  90                  95      


Gly Phe Asn Asn Ser Leu Pro Asn Lys Asp His Arg Asn Asp Ile Met 
            100                 105                 110         


Leu Val Lys Met Ala Ser Pro Val Ser Ile Thr Trp Ala Val Arg Pro 
        115                 120                 125             


Leu Thr Leu Ser Ser Arg Cys Val Thr Ala Gly Thr Ser Cys Leu Ile 
    130                 135                 140                 


Ser Gly Trp Gly Ser Thr Ser Ser Pro Gln Leu Arg Leu Pro His Thr 
145                 150                 155                 160 


Leu Arg Cys Ala Asn Ile Thr Ile Ile Glu His Gln Lys Cys Glu Asn 
                165                 170                 175     


Ala Tyr Pro Gly Asn Ile Thr Asp Thr Met Val Cys Ala Ser Val Gln 
            180                 185                 190         


Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Gln Ser Leu Gln Gly Ile Ile Ser Trp Gly Gln Asp Pro Cys 
    210                 215                 220                 


Ala Ile Thr Arg Lys Pro Gly Val Tyr Thr Lys Val Cys Lys Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Gln Glu Thr Met Lys Asn Asn 
                245                 250 


<210>  5968
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK12__Homo_sapiens__NP_062544

<400>  5968

Met Gly Leu Ser Ile Phe Leu Leu Leu Cys Val Leu Gly Leu Ser Gln 
1               5                   10                  15      


Ala Ala Thr Pro Lys Ile Phe Asn Gly Thr Glu Cys Gly Arg Asn Ser 
            20                  25                  30          


Gln Pro Trp Gln Val Gly Leu Phe Glu Gly Thr Ser Leu Arg Cys Gly 
        35                  40                  45              


Gly Val Leu Ile Asp His Arg Trp Val Leu Thr Ala Ala His Cys Ser 
    50                  55                  60                  


Gly Ser Arg Tyr Trp Val Arg Leu Gly Glu His Ser Leu Ser Gln Leu 
65                  70                  75                  80  


Asp Trp Thr Glu Gln Ile Arg His Ser Gly Phe Ser Val Thr His Pro 
                85                  90                  95      


Gly Tyr Leu Gly Ala Ser Thr Ser His Glu His Asp Leu Arg Leu Leu 
            100                 105                 110         


Arg Leu Arg Leu Pro Val Arg Val Thr Ser Ser Val Gln Pro Leu Pro 
        115                 120                 125             


Leu Pro Asn Asp Cys Ala Thr Ala Gly Thr Glu Cys His Val Ser Gly 
    130                 135                 140                 


Trp Gly Ile Thr Asn His Pro Arg Asn Pro Phe Pro Asp Leu Leu Gln 
145                 150                 155                 160 


Cys Leu Asn Leu Ser Ile Val Ser His Ala Thr Cys His Gly Val Tyr 
                165                 170                 175     


Pro Gly Arg Ile Thr Ser Asn Met Val Cys Ala Gly Gly Val Pro Gly 
            180                 185                 190         


Gln Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly 
        195                 200                 205             


Val Leu Gln Gly Leu Val Ser Trp Gly Ser Val Gly Pro Cys Gly Gln 
    210                 215                 220                 


Asp Gly Ile Pro Gly Val Tyr Thr Tyr Ile Cys Asn Ser Thr Leu Val 
225                 230                 235                 240 


Gly Leu Gly Thr Ser Trp Asn Phe Asn Ser Cys Gln Pro Phe 
                245                 250                 


<210>  5969
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK13__Homo_sapiens__NP_056411

<400>  5969

Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser 
1               5                   10                  15      


Gly Gly Val Ser Gln Glu Ser Ser Lys Val Leu Asn Thr Asn Gly Thr 
            20                  25                  30          


Ser Gly Phe Leu Pro Gly Gly Tyr Thr Cys Phe Pro His Ser Gln Pro 
        35                  40                  45              


Trp Gln Ala Ala Leu Leu Val Gln Gly Arg Leu Leu Cys Gly Gly Val 
    50                  55                  60                  


Leu Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Lys Glu 
65                  70                  75                  80  


Gly Leu Lys Val Tyr Leu Gly Lys His Ala Leu Gly Arg Val Glu Ala 
                85                  90                  95      


Gly Glu Gln Val Arg Glu Val Val His Ser Ile Pro His Pro Glu Tyr 
            100                 105                 110         


Arg Arg Ser Pro Thr His Leu Asn His Asp His Asp Ile Met Leu Leu 
        115                 120                 125             


Glu Leu Gln Ser Pro Val Gln Leu Thr Gly Tyr Ile Gln Thr Leu Pro 
    130                 135                 140                 


Leu Ser His Asn Asn Arg Leu Thr Pro Gly Thr Thr Cys Arg Val Ser 
145                 150                 155                 160 


Gly Trp Gly Thr Thr Thr Ser Pro Gln Val Asn Tyr Pro Lys Thr Leu 
                165                 170                 175     


Gln Cys Ala Asn Ile Gln Leu Arg Ser Asp Glu Glu Cys Arg Gln Val 
            180                 185                 190         


Tyr Pro Gly Lys Ile Thr Asp Asn Met Leu Cys Ala Gly Thr Lys Glu 
        195                 200                 205             


Gly Gly Lys Asp Ser Cys Glu Gly Asp Ser Gly Gly Pro Leu Val Cys 
    210                 215                 220                 


Asn Arg Thr Leu Tyr Gly Ile Val Ser Trp Gly Asp Phe Pro Cys Gly 
225                 230                 235                 240 


Gln Pro Asp Arg Pro Gly Val Tyr Thr Arg Val Ser Arg Tyr Val Leu 
                245                 250                 255     


Trp Ile Arg Glu Thr Ile Arg Lys Tyr Glu Thr Gln Gln Gln Lys Trp 
            260                 265                 270         


Leu Lys Gly Pro Gln 
        275         


<210>  5970
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK14__Homo_sapiens__NP_071329

<400>  5970

Met Ser Leu Arg Val Leu Gly Ser Gly Thr Trp Pro Ser Ala Pro Lys 
1               5                   10                  15      


Met Phe Leu Leu Leu Thr Ala Leu Gln Val Leu Ala Ile Ala Met Thr 
            20                  25                  30          


Gln Ser Gln Glu Asp Glu Asn Lys Ile Ile Gly Gly His Thr Cys Thr 
        35                  40                  45              


Arg Ser Ser Gln Pro Trp Gln Ala Ala Leu Leu Ala Gly Pro Arg Arg 
    50                  55                  60                  


Arg Phe Leu Cys Gly Gly Ala Leu Leu Ser Gly Gln Trp Val Ile Thr 
65                  70                  75                  80  


Ala Ala His Cys Gly Arg Pro Ile Leu Gln Val Ala Leu Gly Lys His 
                85                  90                  95      


Asn Leu Arg Arg Trp Glu Ala Thr Gln Gln Val Leu Arg Val Val Arg 
            100                 105                 110         


Gln Val Thr His Pro Asn Tyr Asn Ser Arg Thr His Asp Asn Asp Leu 
        115                 120                 125             


Met Leu Leu Gln Leu Gln Gln Pro Ala Arg Ile Gly Arg Ala Val Arg 
    130                 135                 140                 


Pro Ile Glu Val Thr Gln Ala Cys Ala Ser Pro Gly Thr Ser Cys Arg 
145                 150                 155                 160 


Val Ser Gly Trp Gly Thr Ile Ser Ser Pro Ile Ala Arg Tyr Pro Ala 
                165                 170                 175     


Ser Leu Gln Cys Val Asn Ile Asn Ile Ser Pro Asp Glu Val Cys Gln 
            180                 185                 190         


Lys Ala Tyr Pro Arg Thr Ile Thr Pro Gly Met Val Cys Ala Gly Val 
        195                 200                 205             


Pro Gln Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
    210                 215                 220                 


Val Cys Arg Gly Gln Leu Gln Gly Leu Val Ser Trp Gly Met Glu Arg 
225                 230                 235                 240 


Cys Ala Leu Pro Gly Tyr Pro Gly Val Tyr Thr Asn Leu Cys Lys Tyr 
                245                 250                 255     


Arg Ser Trp Ile Glu Glu Thr Met Arg Asp Lys 
            260                 265         


<210>  5971
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK15__Homo_sapiens__NP_001264010

<400>  5971

Met Trp Leu Leu Leu Thr Leu Ser Phe Leu Leu Ala Ser Thr Ala Gln 
1               5                   10                  15      


Asp Gly Asp Lys Leu Leu Glu Gly Asp Glu Cys Ala Pro His Ser Gln 
            20                  25                  30          


Pro Trp Gln Val Ala Leu Tyr Glu Arg Gly Arg Phe Asn Cys Gly Ala 
        35                  40                  45              


Ser Leu Ile Ser Pro His Trp Val Leu Ser Ala Ala His Cys Gln Ser 
    50                  55                  60                  


Arg Phe Met Arg Val Arg Leu Gly Glu His Asn Leu Arg Lys Arg Asp 
65                  70                  75                  80  


Gly Pro Glu Gln Leu Arg Thr Thr Ser Arg Val Ile Pro His Pro Arg 
                85                  90                  95      


Tyr Glu Ala Arg Ser His Arg Asn Asp Ile Met Leu Leu Arg Leu Val 
            100                 105                 110         


Gln Pro Ala Arg Leu Asn Pro Gln Val Arg Pro Ala Val Leu Pro Thr 
        115                 120                 125             


Arg Cys Pro His Pro Gly Glu Ala Cys Val Val Ser Gly Trp Gly Leu 
    130                 135                 140                 


Val Ser His Asn Glu Pro Gly Thr Ala Gly Ser Pro Arg Ser Gln Val 
145                 150                 155                 160 


Ser Leu Pro Asp Thr Leu His Cys Ala Asn Ile Ser Ile Ile Ser Asp 
                165                 170                 175     


Thr Ser Cys Asp Lys Ser Tyr Pro Gly Arg Leu Thr Asn Thr Met Val 
            180                 185                 190         


Cys Ala Gly Ala Glu Gly Arg Gly Ala Glu Ser Cys Glu Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Ile Leu Gln Gly Ile Val Ser Trp 
    210                 215                 220                 


Gly Asp Val Pro Cys Asp Asn Thr Thr Lys Pro Gly Val Tyr Thr Lys 
225                 230                 235                 240 


Val Cys His Tyr Leu Glu Trp Ile Arg Glu Thr Met Lys Arg Asn 
                245                 250                 255 


<210>  5972
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK1__Homo_sapiens__NP_002248

<400>  5972

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Gly 
1               5                   10                  15      


Ala Ala Pro Pro Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Gln His Ser Gln Pro Trp Gln Ala Ala Leu Tyr His Phe Ser Thr Phe 
        35                  40                  45              


Gln Cys Gly Gly Ile Leu Val His Arg Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Ser Asp Asn Tyr Gln Leu Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Asp Asp Glu Asn Thr Ala Gln Phe Val His Val Ser Glu Ser Phe 
                85                  90                  95      


Pro His Pro Gly Phe Asn Met Ser Leu Leu Glu Asn His Thr Arg Gln 
            100                 105                 110         


Ala Asp Glu Asp Tyr Ser His Asp Leu Met Leu Leu Arg Leu Thr Glu 
        115                 120                 125             


Pro Ala Asp Thr Ile Thr Asp Ala Val Lys Val Val Glu Leu Pro Thr 
    130                 135                 140                 


Glu Glu Pro Glu Val Gly Ser Thr Cys Leu Ala Ser Gly Trp Gly Ser 
145                 150                 155                 160 


Ile Glu Pro Glu Asn Phe Ser Phe Pro Asp Asp Leu Gln Cys Val Asp 
                165                 170                 175     


Leu Lys Ile Leu Pro Asn Asp Glu Cys Lys Lys Ala His Val Gln Lys 
            180                 185                 190         


Val Thr Asp Phe Met Leu Cys Val Gly His Leu Glu Gly Gly Lys Asp 
        195                 200                 205             


Thr Cys Val Gly Asp Ser Gly Gly Pro Leu Met Cys Asp Gly Val Leu 
    210                 215                 220                 


Gln Gly Val Thr Ser Trp Gly Tyr Val Pro Cys Gly Thr Pro Asn Lys 
225                 230                 235                 240 


Pro Ser Val Ala Val Arg Val Leu Ser Tyr Val Lys Trp Ile Glu Asp 
                245                 250                 255     


Thr Ile Ala Glu Asn Ser 
            260         


<210>  5973
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK2__Homo_sapiens__NP_001002231

<400>  5973

Met Trp Asp Leu Val Leu Ser Ile Ala Leu Ser Val Gly Cys Thr Gly 
1               5                   10                  15      


Ala Val Pro Leu Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Ala Val Tyr Ser His Gly Trp Ala 
        35                  40                  45              


His Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Leu Lys Lys Asn Ser Gln Val Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Glu Pro Glu Asp Thr Gly Gln Arg Val Pro Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asn Met Ser Leu Leu Lys His Gln Ser Leu Arg 
            100                 105                 110         


Pro Asp Glu Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Lys Ile Thr Asp Val Val Lys Val Leu Gly Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Arg Pro Arg Ser Leu Gln Cys Val Ser Leu 
                165                 170                 175     


His Leu Leu Ser Asn Asp Met Cys Ala Arg Ala Tyr Ser Glu Lys Val 
            180                 185                 190         


Thr Glu Phe Met Leu Cys Ala Gly Leu Trp Thr Gly Gly Lys Asp Thr 
        195                 200                 205             


Cys Gly Val Ser His Pro Tyr Ser Gln His Leu Glu Gly Lys Gly 
    210                 215                 220             


<210>  5974
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK3__Homo_sapiens__NP_001025218

<400>  5974

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr Met Pro Ala Leu Pro 
    210                 215                 220                 


Met Val Leu His Gly Ser Leu Val Pro Trp Arg Gly Gly Val 
225                 230                 235             


<210>  5975
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK4__Homo_sapiens__NP_004908

<400>  5975

Met Ala Thr Ala Gly Asn Pro Trp Gly Trp Phe Leu Gly Tyr Leu Ile 
1               5                   10                  15      


Leu Gly Val Ala Gly Ser Leu Val Ser Gly Ser Cys Ser Gln Ile Ile 
            20                  25                  30          


Asn Gly Glu Asp Cys Ser Pro His Ser Gln Pro Trp Gln Ala Ala Leu 
        35                  40                  45              


Val Met Glu Asn Glu Leu Phe Cys Ser Gly Val Leu Val His Pro Gln 
    50                  55                  60                  


Trp Val Leu Ser Ala Ala His Cys Phe Gln Asn Ser Tyr Thr Ile Gly 
65                  70                  75                  80  


Leu Gly Leu His Ser Leu Glu Ala Asp Gln Glu Pro Gly Ser Gln Met 
                85                  90                  95      


Val Glu Ala Ser Leu Ser Val Arg His Pro Glu Tyr Asn Arg Pro Leu 
            100                 105                 110         


Leu Ala Asn Asp Leu Met Leu Ile Lys Leu Asp Glu Ser Val Ser Glu 
        115                 120                 125             


Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser Gln Cys Pro Thr Ala 
    130                 135                 140                 


Gly Asn Ser Cys Leu Val Ser Gly Trp Gly Leu Leu Ala Asn Gly Arg 
145                 150                 155                 160 


Met Pro Thr Val Leu Gln Cys Val Asn Val Ser Val Val Ser Glu Glu 
                165                 170                 175     


Val Cys Ser Lys Leu Tyr Asp Pro Leu Tyr His Pro Ser Met Phe Cys 
            180                 185                 190         


Ala Gly Gly Gly Gln Asp Gln Lys Asp Ser Cys Asn Gly Asp Ser Gly 
        195                 200                 205             


Gly Pro Leu Ile Cys Asn Gly Tyr Leu Gln Gly Leu Val Ser Phe Gly 
    210                 215                 220                 


Lys Ala Pro Cys Gly Gln Val Gly Val Pro Gly Val Tyr Thr Asn Leu 
225                 230                 235                 240 


Cys Lys Phe Thr Glu Trp Ile Glu Lys Thr Val Gln Ala Ser 
                245                 250                 


<210>  5976
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK5__Homo_sapiens__NP_036559

<400>  5976

Met Ala Thr Ala Arg Pro Pro Trp Met Trp Val Leu Cys Ala Leu Ile 
1               5                   10                  15      


Thr Ala Leu Leu Leu Gly Val Thr Glu His Val Leu Ala Asn Asn Asp 
            20                  25                  30          


Val Ser Cys Asp His Pro Ser Asn Thr Val Pro Ser Gly Ser Asn Gln 
        35                  40                  45              


Asp Leu Gly Ala Gly Ala Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser 
    50                  55                  60                  


Ser Arg Ile Ile Asn Gly Ser Asp Cys Asp Met His Thr Gln Pro Trp 
65                  70                  75                  80  


Gln Ala Ala Leu Leu Leu Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val 
                85                  90                  95      


Leu Val His Pro Gln Trp Leu Leu Thr Ala Ala His Cys Arg Lys Lys 
            100                 105                 110         


Val Phe Arg Val Arg Leu Gly His Tyr Ser Leu Ser Pro Val Tyr Glu 
        115                 120                 125             


Ser Gly Gln Gln Met Phe Gln Gly Val Lys Ser Ile Pro His Pro Gly 
    130                 135                 140                 


Tyr Ser His Pro Gly His Ser Asn Asp Leu Met Leu Ile Lys Leu Asn 
145                 150                 155                 160 


Arg Arg Ile Arg Pro Thr Lys Asp Val Arg Pro Ile Asn Val Ser Ser 
                165                 170                 175     


His Cys Pro Ser Ala Gly Thr Lys Cys Leu Val Ser Gly Trp Gly Thr 
            180                 185                 190         


Thr Lys Ser Pro Gln Val His Phe Pro Lys Val Leu Gln Cys Leu Asn 
        195                 200                 205             


Ile Ser Val Leu Ser Gln Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln 
    210                 215                 220                 


Ile Asp Asp Thr Met Phe Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser 
225                 230                 235                 240 


Cys Gln Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Ser Leu Gln 
                245                 250                 255     


Gly Leu Val Ser Trp Gly Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro 
            260                 265                 270         


Gly Val Tyr Thr Asn Leu Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr 
        275                 280                 285             


Ile Gln Ala Asn Ser 
    290             


<210>  5977
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK6__Homo_sapiens__NP_001012982

<400>  5977

Met Lys Lys Leu Met Val Val Leu Ser Leu Ile Ala Ala Ala Trp Ala 
1               5                   10                  15      


Glu Glu Gln Asn Lys Leu Val His Gly Gly Pro Cys Asp Lys Thr Ser 
            20                  25                  30          


His Pro Tyr Gln Ala Ala Leu Tyr Thr Ser Gly His Leu Leu Cys Gly 
        35                  40                  45              


Gly Val Leu Ile His Pro Leu Trp Val Leu Thr Ala Ala His Cys Lys 
    50                  55                  60                  


Lys Pro Asn Leu Gln Val Phe Leu Gly Lys His Asn Leu Arg Gln Arg 
65                  70                  75                  80  


Glu Ser Ser Gln Glu Gln Ser Ser Val Val Arg Ala Val Ile His Pro 
                85                  90                  95      


Asp Tyr Asp Ala Ala Ser His Asp Gln Asp Ile Met Leu Leu Arg Leu 
            100                 105                 110         


Ala Arg Pro Ala Lys Leu Ser Glu Leu Ile Gln Pro Leu Pro Leu Glu 
        115                 120                 125             


Arg Asp Cys Ser Ala Asn Thr Thr Ser Cys His Ile Leu Gly Trp Gly 
    130                 135                 140                 


Lys Thr Ala Asp Gly Asp Phe Pro Asp Thr Ile Gln Cys Ala Tyr Ile 
145                 150                 155                 160 


His Leu Val Ser Arg Glu Glu Cys Glu His Ala Tyr Pro Gly Gln Ile 
                165                 170                 175     


Thr Gln Asn Met Leu Cys Ala Gly Asp Glu Lys Tyr Gly Lys Asp Ser 
            180                 185                 190         


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Asp His Leu Arg 
        195                 200                 205             


Gly Leu Val Ser Trp Gly Asn Ile Pro Cys Gly Ser Lys Glu Lys Pro 
    210                 215                 220                 


Gly Val Tyr Thr Asn Val Cys Arg Tyr Thr Asn Trp Ile Gln Lys Thr 
225                 230                 235                 240 


Ile Gln Ala Lys 
                


<210>  5978
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK7__Homo_sapiens__NP_001193982

<400>  5978

Met Asn Glu Tyr Thr Val His Leu Gly Ser Asp Thr Leu Gly Asp Arg 
1               5                   10                  15      


Arg Ala Gln Arg Ile Lys Ala Ser Lys Ser Phe Arg His Pro Gly Tyr 
            20                  25                  30          


Ser Thr Gln Thr His Val Asn Asp Leu Met Leu Val Lys Leu Asn Ser 
        35                  40                  45              


Gln Ala Arg Leu Ser Ser Met Val Lys Lys Val Arg Leu Pro Ser Arg 
    50                  55                  60                  


Cys Glu Pro Pro Gly Thr Thr Cys Thr Val Ser Gly Trp Gly Thr Thr 
65                  70                  75                  80  


Thr Ser Pro Asp Val Thr Phe Pro Ser Asp Leu Met Cys Val Asp Val 
                85                  90                  95      


Lys Leu Ile Ser Pro Gln Asp Cys Thr Lys Val Tyr Lys Asp Leu Leu 
            100                 105                 110         


Glu Asn Ser Met Leu Cys Ala Gly Ile Pro Asp Ser Lys Lys Asn Ala 
        115                 120                 125             


Cys Asn Gly Asp Ser Gly Gly Pro Leu Val Cys Arg Gly Thr Leu Gln 
    130                 135                 140                 


Gly Leu Val Ser Trp Gly Thr Phe Pro Cys Gly Gln Pro Asn Asp Pro 
145                 150                 155                 160 


Gly Val Tyr Thr Gln Val Cys Lys Phe Thr Lys Trp Ile Asn Asp Thr 
                165                 170                 175     


Met Lys Lys His Arg 
            180     


<210>  5979
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK8__Homo_sapiens__NP_009127

<400>  5979

Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu 
1               5                   10                  15      


Leu Leu Gly Gly Ala Trp Ala Gly His Ser Arg Ala Gln Glu Asp Lys 
            20                  25                  30          


Val Leu Gly Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala 
        35                  40                  45              


Ala Leu Phe Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly 
    50                  55                  60                  


Gly Asn Trp Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr 
65                  70                  75                  80  


Val Arg Leu Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln 
                85                  90                  95      


Glu Ile Pro Val Val Gln Ser Ile Pro His Pro Cys Tyr Asn Ser Ser 
            100                 105                 110         


Asp Val Glu Asp His Asn His Asp Leu Met Leu Leu Gln Leu Arg Asp 
        115                 120                 125             


Gln Ala Ser Leu Gly Ser Lys Val Lys Pro Ile Ser Leu Ala Asp His 
    130                 135                 140                 


Cys Thr Gln Pro Gly Gln Lys Cys Thr Val Ser Gly Trp Gly Thr Val 
145                 150                 155                 160 


Thr Ser Pro Arg Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val 
                165                 170                 175     


Lys Ile Phe Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro Gly Gln Ile 
            180                 185                 190         


Thr Asp Gly Met Val Cys Ala Gly Ser Ser Lys Gly Ala Asp Thr Cys 
        195                 200                 205             


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Ala Leu Gln Gly 
    210                 215                 220                 


Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp Lys Pro Gly 
225                 230                 235                 240 


Val Tyr Thr Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys Lys Ile Ile 
                245                 250                 255     


Gly Ser Lys Gly 
            260 


<210>  5980
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK9__Homo_sapiens__NP_036447

<400>  5980

Met Lys Leu Gly Leu Leu Cys Ala Leu Leu Ser Leu Leu Ala Gly His 
1               5                   10                  15      


Gly Trp Ala Asp Thr Arg Ala Ile Gly Ala Glu Glu Cys Arg Pro Asn 
            20                  25                  30          


Ser Gln Pro Trp Gln Ala Gly Leu Phe His Leu Thr Arg Leu Phe Cys 
        35                  40                  45              


Gly Ala Thr Leu Ile Ser Asp Arg Trp Leu Leu Thr Ala Ala His Cys 
    50                  55                  60                  


Arg Lys Pro Tyr Leu Trp Val Arg Leu Gly Glu His His Leu Trp Lys 
65                  70                  75                  80  


Trp Glu Gly Pro Glu Gln Leu Phe Arg Val Thr Asp Phe Phe Pro His 
                85                  90                  95      


Pro Gly Phe Asn Lys Asp Leu Ser Ala Asn Asp His Asn Asp Asp Ile 
            100                 105                 110         


Met Leu Ile Arg Leu Pro Arg Gln Ala Arg Leu Ser Pro Ala Val Gln 
        115                 120                 125             


Pro Leu Asn Leu Ser Gln Thr Cys Val Ser Pro Gly Met Gln Cys Leu 
    130                 135                 140                 


Ile Ser Gly Trp Gly Ala Val Ser Ser Pro Lys Ala Leu Phe Pro Val 
145                 150                 155                 160 


Thr Leu Gln Cys Ala Asn Ile Ser Ile Leu Glu Asn Lys Leu Cys His 
                165                 170                 175     


Trp Ala Tyr Pro Gly His Ile Ser Asp Ser Met Leu Cys Ala Gly Leu 
            180                 185                 190         


Trp Glu Gly Gly Arg Gly Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
        195                 200                 205             


Val Cys Asn Gly Thr Leu Ala Gly Val Val Ser Gly Gly Ala Glu Pro 
    210                 215                 220                 


Cys Ser Arg Pro Arg Arg Pro Ala Val Tyr Thr Ser Val Cys His Tyr 
225                 230                 235                 240 


Leu Asp Trp Ile Gln Glu Ile Met Glu Asn 
                245                 250 


<210>  5981
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLKB1__Homo_sapiens__NP_000883

<400>  5981

Met Ile Leu Phe Lys Gln Ala Thr Tyr Phe Ile Ser Leu Phe Ala Thr 
1               5                   10                  15      


Val Ser Cys Gly Cys Leu Thr Gln Leu Tyr Glu Asn Ala Phe Phe Arg 
            20                  25                  30          


Gly Gly Asp Val Ala Ser Met Tyr Thr Pro Asn Ala Gln Tyr Cys Gln 
        35                  40                  45              


Met Arg Cys Thr Phe His Pro Arg Cys Leu Leu Phe Ser Phe Leu Pro 
    50                  55                  60                  


Ala Ser Ser Ile Asn Asp Met Glu Lys Arg Phe Gly Cys Phe Leu Lys 
65                  70                  75                  80  


Asp Ser Val Thr Gly Thr Leu Pro Lys Val His Arg Thr Gly Ala Val 
                85                  90                  95      


Ser Gly His Ser Leu Lys Gln Cys Gly His Gln Ile Ser Ala Cys His 
            100                 105                 110         


Arg Asp Ile Tyr Lys Gly Val Asp Met Arg Gly Val Asn Phe Asn Val 
        115                 120                 125             


Ser Lys Val Ser Ser Val Glu Glu Cys Gln Lys Arg Cys Thr Ser Asn 
    130                 135                 140                 


Ile Arg Cys Gln Phe Phe Ser Tyr Ala Thr Gln Thr Phe His Lys Ala 
145                 150                 155                 160 


Glu Tyr Arg Asn Asn Cys Leu Leu Lys Tyr Ser Pro Gly Gly Thr Pro 
                165                 170                 175     


Thr Ala Ile Lys Val Leu Ser Asn Val Glu Ser Gly Phe Ser Leu Lys 
            180                 185                 190         


Pro Cys Ala Leu Ser Glu Ile Gly Cys His Met Asn Ile Phe Gln His 
        195                 200                 205             


Leu Ala Phe Ser Asp Val Asp Val Ala Arg Val Leu Thr Pro Asp Ala 
    210                 215                 220                 


Phe Val Cys Arg Thr Ile Cys Thr Tyr His Pro Asn Cys Leu Phe Phe 
225                 230                 235                 240 


Thr Phe Tyr Thr Asn Val Trp Lys Ile Glu Ser Gln Arg Asn Val Cys 
                245                 250                 255     


Leu Leu Lys Thr Ser Glu Ser Gly Thr Pro Ser Ser Ser Thr Pro Gln 
            260                 265                 270         


Glu Asn Thr Ile Ser Gly Tyr Ser Leu Leu Thr Cys Lys Arg Thr Leu 
        275                 280                 285             


Pro Glu Pro Cys His Ser Lys Ile Tyr Pro Gly Val Asp Phe Gly Gly 
    290                 295                 300                 


Glu Glu Leu Asn Val Thr Phe Val Lys Gly Val Asn Val Cys Gln Glu 
305                 310                 315                 320 


Thr Cys Thr Lys Met Ile Arg Cys Gln Phe Phe Thr Tyr Ser Leu Leu 
                325                 330                 335     


Pro Glu Asp Cys Lys Glu Glu Lys Cys Lys Cys Phe Leu Arg Leu Ser 
            340                 345                 350         


Met Asp Gly Ser Pro Thr Arg Ile Ala Tyr Gly Thr Gln Gly Ser Ser 
        355                 360                 365             


Gly Tyr Ser Leu Arg Leu Cys Asn Thr Gly Asp Asn Ser Val Cys Thr 
    370                 375                 380                 


Thr Lys Thr Ser Thr Arg Ile Val Gly Gly Thr Asn Ser Ser Trp Gly 
385                 390                 395                 400 


Glu Trp Pro Trp Gln Val Ser Leu Gln Val Lys Leu Thr Ala Gln Arg 
                405                 410                 415     


His Leu Cys Gly Gly Ser Leu Ile Gly His Gln Trp Val Leu Thr Ala 
            420                 425                 430         


Ala His Cys Phe Asp Gly Leu Pro Leu Gln Asp Val Trp Arg Ile Tyr 
        435                 440                 445             


Ser Gly Ile Leu Asn Leu Ser Asp Ile Thr Lys Asp Thr Pro Phe Ser 
    450                 455                 460                 


Gln Ile Lys Glu Ile Ile Ile His Gln Asn Tyr Lys Val Ser Glu Gly 
465                 470                 475                 480 


Asn His Asp Ile Ala Leu Ile Lys Leu Gln Ala Pro Leu Asn Tyr Thr 
                485                 490                 495     


Glu Phe Gln Lys Pro Ile Cys Leu Pro Ser Lys Gly Asp Thr Ser Thr 
            500                 505                 510         


Ile Tyr Thr Asn Cys Trp Val Thr Gly Trp Gly Phe Ser Lys Glu Lys 
        515                 520                 525             


Gly Glu Ile Gln Asn Ile Leu Gln Lys Val Asn Ile Pro Leu Val Thr 
    530                 535                 540                 


Asn Glu Glu Cys Gln Lys Arg Tyr Gln Asp Tyr Lys Ile Thr Gln Arg 
545                 550                 555                 560 


Met Val Cys Ala Gly Tyr Lys Glu Gly Gly Lys Asp Ala Cys Lys Gly 
                565                 570                 575     


Asp Ser Gly Gly Pro Leu Val Cys Lys His Asn Gly Met Trp Arg Leu 
            580                 585                 590         


Val Gly Ile Thr Ser Trp Gly Glu Gly Cys Ala Arg Arg Glu Gln Pro 
        595                 600                 605             


Gly Val Tyr Thr Lys Val Ala Glu Tyr Met Asp Trp Ile Leu Glu Lys 
    610                 615                 620                 


Thr Gln Ser Ser Asp Gly Lys Ala Gln Met Gln Ser Pro Ala 
625                 630                 635             


<210>  5982
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLLN__Homo_sapiens__NP_001119521

<400>  5982

Met Asp Arg Pro Gly Pro Gly Ser Ala Arg Pro Gly Arg Thr Val His 
1               5                   10                  15      


Val Trp Gly Tyr Arg Val Glu Trp Lys Val Arg Asn Gly Arg Lys Leu 
            20                  25                  30          


Gln Pro Ser Glu Trp Ala Gly Arg Gly Asp Leu Gly Gly Phe Lys Arg 
        35                  40                  45              


Arg Trp Lys Asp Thr Arg Ala Thr Val Gly Thr Thr Phe Arg Arg Arg 
    50                  55                  60                  


Ser Arg Val Ser Leu Val Gly Glu Leu Ser Lys Phe Pro Leu Pro Ser 
65                  70                  75                  80  


Asp Ser Ser Gly Gly Lys Ser Ser Ser Ser Phe Ala Arg Gly Ala Leu 
                85                  90                  95      


Ala Trp Cys Arg Gln Arg Asn Pro Asn Pro Ser Cys Ala Ala Ala Glu 
            100                 105                 110         


Thr Gly Ala Arg Thr Ser Leu Pro Lys Glu Arg Cys Arg Gly Trp Arg 
        115                 120                 125             


Leu Gly Asn Trp Leu His Lys His Pro His Pro Asn Thr Cys Pro Arg 
    130                 135                 140                 


Leu Pro Ala Cys Trp Leu Pro Pro Ile Leu Thr Glu Arg Gly Glu Arg 
145                 150                 155                 160 


Val Pro Lys Leu Val Pro Leu Leu Ala Cys Tyr Pro Lys Ser Lys Pro 
                165                 170                 175     


Lys Asp 
        


<210>  5983
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRB1__Homo_sapiens__NP_002249

<400>  5983

Met Asp Gln Gln Ala Ile Tyr Ala Glu Leu Asn Leu Pro Thr Asp Ser 
1               5                   10                  15      


Gly Pro Glu Ser Ser Ser Pro Ser Ser Leu Pro Arg Asp Val Cys Gln 
            20                  25                  30          


Gly Ser Pro Trp His Gln Phe Ala Leu Lys Leu Ser Cys Ala Gly Ile 
        35                  40                  45              


Ile Leu Leu Val Leu Val Val Thr Gly Leu Ser Val Ser Val Thr Ser 
    50                  55                  60                  


Leu Ile Gln Lys Ser Ser Ile Glu Lys Cys Ser Val Asp Ile Gln Gln 
65                  70                  75                  80  


Ser Arg Asn Lys Thr Thr Glu Arg Pro Gly Leu Leu Asn Cys Pro Ile 
                85                  90                  95      


Tyr Trp Gln Gln Leu Arg Glu Lys Cys Leu Leu Phe Ser His Thr Val 
            100                 105                 110         


Asn Pro Trp Asn Asn Ser Leu Ala Asp Cys Ser Thr Lys Glu Ser Ser 
        115                 120                 125             


Leu Leu Leu Ile Arg Asp Lys Asp Glu Leu Ile His Thr Gln Asn Leu 
    130                 135                 140                 


Ile Arg Asp Lys Ala Ile Leu Phe Trp Ile Gly Leu Asn Phe Ser Leu 
145                 150                 155                 160 


Ser Glu Lys Asn Trp Lys Trp Ile Asn Gly Ser Phe Leu Asn Ser Asn 
                165                 170                 175     


Asp Leu Glu Ile Arg Gly Asp Ala Lys Glu Asn Ser Cys Ile Ser Ile 
            180                 185                 190         


Ser Gln Thr Ser Val Tyr Ser Glu Tyr Cys Ser Thr Glu Ile Arg Trp 
        195                 200                 205             


Ile Cys Gln Lys Glu Leu Thr Pro Val Arg Asn Lys Val Tyr Pro Asp 
    210                 215                 220                 


Ser 
225 


<210>  5984
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRC1__Homo_sapiens__NP_998822

<400>  5984

Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys Leu Ile Val Gly Ile Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Leu Ile Leu Met Ala Ser Val Val Thr Ile Val Val Ile Pro Ser Arg 
                85                  90                  95      


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
            100                 105                 110         


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
        115                 120                 125             


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
    130                 135                 140                 


Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly Val Phe 
145                 150                 155                 160 


Arg Asn Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu Ala Phe 
                165                 170                 175     


Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
            180                 185                 190         


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Ile Ile 
        195                 200                 205             


Tyr His Cys Lys His Lys Leu 
    210                 215 


<210>  5985
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRC2__Homo_sapiens__NP_002251

<400>  5985

Met Asn Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Phe Ser Pro Asn Thr Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
    130                 135                 140                 


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
145                 150                 155                 160 


Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val Phe 
                165                 170                 175     


Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala Phe 
            180                 185                 190         


Lys His Lys Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
        195                 200                 205             


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Met Ile 
    210                 215                 220                 


Tyr His Cys Lys His Lys Leu 
225                 230     


<210>  5986
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRC4__Homo_sapiens__NP_038459

<400>  5986

Met Asn Lys Gln Arg Gly Thr Tyr Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Leu Lys Gly Asn Lys Ile Ser Ile Ser 
            20                  25                  30          


Gly Thr Lys Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Ser Asp His Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Cys 
                85                  90                  95      


Ile Gly Val Leu Glu Gln Asn Asn Phe Ser Leu Asn Arg Arg Met Gln 
            100                 105                 110         


Lys Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser 
        115                 120                 125             


Asn Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Arg 
    130                 135                 140                 


Val Cys Trp Pro Val Leu Arg Arg Thr Leu Ile Cys Phe Leu 
145                 150                 155             


<210>  5987
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRC4-KLRK1__Homo_sapiens__NP_001186734

<400>  5987

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  5988
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRD1__Homo_sapiens__NP_001107868

<400>  5988

Met Ala Val Phe Lys Thr Thr Leu Trp Arg Leu Ile Ser Gly Thr Leu 
1               5                   10                  15      


Gly Ile Ile Cys Leu Ser Leu Met Ala Thr Leu Gly Ile Leu Leu Lys 
            20                  25                  30          


Asn Ser Phe Thr Lys Leu Ser Ile Glu Pro Ala Phe Thr Pro Gly Pro 
        35                  40                  45              


Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys Gln Glu Lys 
    50                  55                  60                  


Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser Glu Gln Lys 
65                  70                  75                  80  


Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys Ser Ser Leu 
                85                  90                  95      


Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser Ser Ser Gln 
            100                 105                 110         


Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His Thr Ala Trp 
        115                 120                 125             


Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe Pro Ser Phe 
    130                 135                 140                 


Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro Asn Gly Asn 
145                 150                 155                 160 


Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile Cys Lys Gln 
                165                 170                 175     


Gln Leu Ile 
            


<210>  5989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRG1__Homo_sapiens__NP_005801

<400>  5989

Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu Leu Thr Ala 
        35                  40                  45              


Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys Gln Gly Ser 
    50                  55                  60                  


Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp Arg Trp Met 
65                  70                  75                  80  


Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His Leu Leu Val 
            100                 105                 110         


Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe Leu Ser Glu 
        115                 120                 125             


Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp Arg Trp Glu 
    130                 135                 140                 


Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn Ser Phe Val 
145                 150                 155                 160 


Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala Ser Ser Cys 
                165                 170                 175     


Glu Val Pro Leu His Trp Val Cys Lys Lys Val Arg Leu 
            180                 185                 


<210>  5990
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLRG2__Homo_sapiens__NP_940910

<400>  5990

Met Glu Glu Ser Trp Glu Ala Ala Pro Gly Gly Gln Ala Gly Ala Glu 
1               5                   10                  15      


Leu Pro Met Glu Pro Val Gly Ser Leu Val Pro Thr Leu Glu Gln Pro 
            20                  25                  30          


Gln Val Pro Ala Lys Val Arg Gln Pro Glu Gly Pro Glu Ser Ser Pro 
        35                  40                  45              


Ser Pro Ala Gly Ala Val Glu Lys Ala Ala Gly Ala Gly Leu Glu Pro 
    50                  55                  60                  


Ser Ser Lys Lys Lys Pro Pro Ser Pro Arg Pro Gly Ser Pro Arg Val 
65                  70                  75                  80  


Pro Pro Leu Ser Leu Gly Tyr Gly Val Cys Pro Glu Pro Pro Ser Pro 
                85                  90                  95      


Gly Pro Ala Leu Val Lys Leu Pro Arg Asn Gly Glu Ala Pro Gly Ala 
            100                 105                 110         


Glu Pro Ala Pro Ser Ala Trp Ala Pro Met Glu Leu Gln Val Asp Val 
        115                 120                 125             


Arg Val Lys Pro Val Gly Ala Ala Gly Gly Ser Ser Thr Pro Ser Pro 
    130                 135                 140                 


Arg Pro Ser Thr Arg Phe Leu Lys Val Pro Val Pro Glu Ser Pro Ala 
145                 150                 155                 160 


Phe Ser Arg His Ala Asp Pro Ala His Gln Leu Leu Leu Arg Ala Pro 
                165                 170                 175     


Ser Gln Gly Gly Thr Trp Gly Arg Arg Ser Pro Leu Ala Ala Ala Arg 
            180                 185                 190         


Thr Glu Ser Gly Cys Asp Ala Glu Gly Arg Ala Ser Pro Ala Glu Gly 
        195                 200                 205             


Ser Ala Gly Ser Pro Gly Ser Pro Thr Cys Cys Arg Cys Lys Glu Leu 
    210                 215                 220                 


Gly Leu Glu Lys Glu Asp Ala Ala Leu Leu Pro Arg Ala Gly Leu Asp 
225                 230                 235                 240 


Gly Asp Glu Lys Leu Pro Arg Ala Val Thr Leu Thr Gly Leu Pro Met 
                245                 250                 255     


Tyr Val Lys Ser Leu Tyr Trp Ala Leu Ala Phe Met Ala Val Leu Leu 
            260                 265                 270         


Ala Val Ser Gly Val Val Ile Val Val Leu Ala Ser Arg Ala Gly Ala 
        275                 280                 285             


Arg Cys Gln Gln Cys Pro Pro Gly Trp Val Leu Ser Glu Glu His Cys 
    290                 295                 300                 


Tyr Tyr Phe Ser Ala Glu Ala Gln Ala Trp Glu Ala Ser Gln Ala Phe 
305                 310                 315                 320 


Cys Ser Ala Tyr His Ala Thr Leu Pro Leu Leu Ser His Thr Gln Asp 
                325                 330                 335     


Phe Leu Gly Arg Tyr Pro Val Ser Arg His Ser Trp Val Gly Ala Trp 
            340                 345                 350         


Arg Gly Pro Gln Gly Trp His Trp Ile Asp Glu Ala Pro Leu Pro Pro 
        355                 360                 365             


Gln Leu Leu Pro Glu Asp Gly Glu Asp Asn Leu Asp Ile Asn Cys Gly 
    370                 375                 380                 


Ala Leu Glu Glu Gly Thr Leu Val Ala Ala Asn Cys Ser Thr Pro Arg 
385                 390                 395                 400 


Pro Trp Val Cys Ala Lys Gly Thr Gln 
                405                 


<210>  5991
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KMO__Homo_sapiens__NP_003670

<400>  5991

Met Asp Ser Ser Val Ile Gln Arg Lys Lys Val Ala Val Ile Gly Gly 
1               5                   10                  15      


Gly Leu Val Gly Ser Leu Gln Ala Cys Phe Leu Ala Lys Arg Asn Phe 
            20                  25                  30          


Gln Ile Asp Val Tyr Glu Ala Arg Glu Asp Thr Arg Val Ala Thr Phe 
        35                  40                  45              


Thr Arg Gly Arg Ser Ile Asn Leu Ala Leu Ser His Arg Gly Arg Gln 
    50                  55                  60                  


Ala Leu Lys Ala Val Gly Leu Glu Asp Gln Ile Val Ser Gln Gly Ile 
65                  70                  75                  80  


Pro Met Arg Ala Arg Met Ile His Ser Leu Ser Gly Lys Lys Ser Ala 
                85                  90                  95      


Ile Pro Tyr Gly Thr Lys Ser Gln Tyr Ile Leu Ser Val Ser Arg Glu 
            100                 105                 110         


Asn Leu Asn Lys Asp Leu Leu Thr Ala Ala Glu Lys Tyr Pro Asn Val 
        115                 120                 125             


Lys Met His Phe Asn His Arg Leu Leu Lys Cys Asn Pro Glu Glu Gly 
    130                 135                 140                 


Met Ile Thr Val Leu Gly Ser Asp Lys Val Pro Lys Asp Val Thr Cys 
145                 150                 155                 160 


Asp Leu Ile Val Gly Cys Asp Gly Ala Tyr Ser Thr Val Arg Ser His 
                165                 170                 175     


Leu Met Lys Lys Pro Arg Phe Asp Tyr Ser Gln Gln Tyr Ile Pro His 
            180                 185                 190         


Gly Tyr Met Glu Leu Thr Ile Pro Pro Lys Asn Gly Asp Tyr Ala Met 
        195                 200                 205             


Glu Pro Asn Tyr Leu His Ile Trp Pro Arg Asn Thr Phe Met Met Ile 
    210                 215                 220                 


Ala Leu Pro Asn Met Asn Lys Ser Phe Thr Cys Thr Leu Phe Met Pro 
225                 230                 235                 240 


Phe Glu Glu Phe Glu Lys Leu Leu Thr Ser Asn Asp Val Val Asp Phe 
                245                 250                 255     


Phe Gln Lys Tyr Phe Pro Asp Ala Ile Pro Leu Ile Gly Glu Lys Leu 
            260                 265                 270         


Leu Val Gln Asp Phe Phe Leu Leu Pro Ala Gln Pro Met Ile Ser Val 
        275                 280                 285             


Lys Cys Ser Ser Phe His Phe Lys Ser His Cys Val Leu Leu Gly Asp 
    290                 295                 300                 


Ala Ala His Ala Ile Val Pro Phe Phe Gly Gln Gly Met Asn Ala Gly 
305                 310                 315                 320 


Phe Glu Asp Cys Leu Val Phe Asp Glu Leu Met Asp Lys Phe Ser Asn 
                325                 330                 335     


Asp Leu Ser Leu Cys Leu Pro Val Phe Ser Arg Leu Arg Ile Pro Asp 
            340                 345                 350         


Asp His Ala Ile Ser Asp Leu Ser Met Tyr Asn Tyr Ile Glu Met Arg 
        355                 360                 365             


Ala His Val Asn Ser Ser Trp Phe Ile Phe Gln Lys Asn Met Glu Arg 
    370                 375                 380                 


Phe Leu His Ala Ile Met Pro Ser Thr Phe Ile Pro Leu Tyr Thr Met 
385                 390                 395                 400 


Val Thr Phe Ser Arg Ile Arg Tyr His Glu Ala Val Gln Arg Trp His 
                405                 410                 415     


Trp Gln Lys Lys Val Ile Asn Lys Gly Leu Phe Phe Leu Gly Ser Leu 
            420                 425                 430         


Ile Ala Ile Ser Ser Thr Tyr Leu Leu Ile His Tyr Met Ser Pro Arg 
        435                 440                 445             


Ser Phe Leu Arg Leu Arg Arg Pro Trp Asn Trp Ile Ala His Phe Arg 
    450                 455                 460                 


Asn Thr Thr Cys Phe Pro Ala Lys Ala Val Asp Ser Leu Glu Gln Ile 
465                 470                 475                 480 


Ser Asn Leu Ile Ser Arg 
                485     


<210>  5992
<211>  3972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KMT2A__Homo_sapiens__NP_001184033

<400>  5992

Met Ala His Ser Cys Arg Trp Arg Phe Pro Ala Arg Pro Gly Thr Thr 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Arg Arg Gly Leu Gly Gly Ala Pro Arg 
            20                  25                  30          


Gln Arg Val Pro Ala Leu Leu Leu Pro Pro Gly Pro Pro Val Gly Gly 
        35                  40                  45              


Gly Gly Pro Gly Ala Pro Pro Ser Pro Pro Ala Val Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Gly Ser Ser Gly Ala Gly Val Pro Gly Gly Ala Ala Ala 
65                  70                  75                  80  


Ala Ser Ala Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Ser Ala Ser Ser Gly Pro Ala Leu Leu Arg Val Gly Pro Gly Phe 
            100                 105                 110         


Asp Ala Ala Leu Gln Val Ser Ala Ala Ile Gly Thr Asn Leu Arg Arg 
        115                 120                 125             


Phe Arg Ala Val Phe Gly Glu Ser Gly Gly Gly Gly Gly Ser Gly Glu 
    130                 135                 140                 


Asp Glu Gln Phe Leu Gly Phe Gly Ser Asp Glu Glu Val Arg Val Arg 
145                 150                 155                 160 


Ser Pro Thr Arg Ser Pro Ser Val Lys Thr Ser Pro Arg Lys Pro Arg 
                165                 170                 175     


Gly Arg Pro Arg Ser Gly Ser Asp Arg Asn Ser Ala Ile Leu Ser Asp 
            180                 185                 190         


Pro Ser Val Phe Ser Pro Leu Asn Lys Ser Glu Thr Lys Ser Gly Asp 
        195                 200                 205             


Lys Ile Lys Lys Lys Asp Ser Lys Ser Ile Glu Lys Lys Arg Gly Arg 
    210                 215                 220                 


Pro Pro Thr Phe Pro Gly Val Lys Ile Lys Ile Thr His Gly Lys Asp 
225                 230                 235                 240 


Ile Ser Glu Leu Pro Lys Gly Asn Lys Glu Asp Ser Leu Lys Lys Ile 
                245                 250                 255     


Lys Arg Thr Pro Ser Ala Thr Phe Gln Gln Ala Thr Lys Ile Lys Lys 
            260                 265                 270         


Leu Arg Ala Gly Lys Leu Ser Pro Leu Lys Ser Lys Phe Lys Thr Gly 
        275                 280                 285             


Lys Leu Gln Ile Gly Arg Lys Gly Val Gln Ile Val Arg Arg Arg Gly 
    290                 295                 300                 


Arg Pro Pro Ser Thr Glu Arg Ile Lys Thr Pro Ser Gly Leu Leu Ile 
305                 310                 315                 320 


Asn Ser Glu Leu Glu Lys Pro Gln Lys Val Arg Lys Asp Lys Glu Gly 
                325                 330                 335     


Thr Pro Pro Leu Thr Lys Glu Asp Lys Thr Val Val Arg Gln Ser Pro 
            340                 345                 350         


Arg Arg Ile Lys Pro Val Arg Ile Ile Pro Ser Ser Lys Arg Thr Asp 
        355                 360                 365             


Ala Thr Ile Ala Lys Gln Leu Leu Gln Arg Ala Lys Lys Gly Ala Gln 
    370                 375                 380                 


Lys Lys Ile Glu Lys Glu Ala Ala Gln Leu Gln Gly Arg Lys Val Lys 
385                 390                 395                 400 


Thr Gln Val Lys Asn Ile Arg Gln Phe Ile Met Pro Val Val Ser Ala 
                405                 410                 415     


Ile Ser Ser Arg Ile Ile Lys Thr Pro Arg Arg Phe Ile Glu Asp Glu 
            420                 425                 430         


Asp Tyr Asp Pro Pro Ile Lys Ile Ala Arg Leu Glu Ser Thr Pro Asn 
        435                 440                 445             


Ser Arg Phe Ser Ala Pro Ser Cys Gly Ser Ser Glu Lys Ser Ser Ala 
    450                 455                 460                 


Ala Ser Gln His Ser Ser Gln Met Ser Ser Asp Ser Ser Arg Ser Ser 
465                 470                 475                 480 


Ser Pro Ser Val Asp Thr Ser Thr Asp Ser Gln Ala Ser Glu Glu Ile 
                485                 490                 495     


Gln Val Leu Pro Glu Glu Arg Ser Asp Thr Pro Glu Val His Pro Pro 
            500                 505                 510         


Leu Pro Ile Ser Gln Ser Pro Glu Asn Glu Ser Asn Asp Arg Arg Ser 
        515                 520                 525             


Arg Arg Tyr Ser Val Ser Glu Arg Ser Phe Gly Ser Arg Thr Thr Lys 
    530                 535                 540                 


Lys Leu Ser Thr Leu Gln Ser Ala Pro Gln Gln Gln Thr Ser Ser Ser 
545                 550                 555                 560 


Pro Pro Pro Pro Leu Leu Thr Pro Pro Pro Pro Leu Gln Pro Ala Ser 
                565                 570                 575     


Ser Ile Ser Asp His Thr Pro Trp Leu Met Pro Pro Thr Ile Pro Leu 
            580                 585                 590         


Ala Ser Pro Phe Leu Pro Ala Ser Thr Ala Pro Met Gln Gly Lys Arg 
        595                 600                 605             


Lys Ser Ile Leu Arg Glu Pro Thr Phe Arg Trp Thr Ser Leu Lys His 
    610                 615                 620                 


Ser Arg Ser Glu Pro Gln Tyr Phe Ser Ser Ala Lys Tyr Ala Lys Glu 
625                 630                 635                 640 


Gly Leu Ile Arg Lys Pro Ile Phe Asp Asn Phe Arg Pro Pro Pro Leu 
                645                 650                 655     


Thr Pro Glu Asp Val Gly Phe Ala Ser Gly Phe Ser Ala Ser Gly Thr 
            660                 665                 670         


Ala Ala Ser Ala Arg Leu Phe Ser Pro Leu His Ser Gly Thr Arg Phe 
        675                 680                 685             


Asp Met His Lys Arg Ser Pro Leu Leu Arg Ala Pro Arg Phe Thr Pro 
    690                 695                 700                 


Ser Glu Ala His Ser Arg Ile Phe Glu Ser Val Thr Leu Pro Ser Asn 
705                 710                 715                 720 


Arg Thr Ser Ala Gly Thr Ser Ser Ser Gly Val Ser Asn Arg Lys Arg 
                725                 730                 735     


Lys Arg Lys Val Phe Ser Pro Ile Arg Ser Glu Pro Arg Ser Pro Ser 
            740                 745                 750         


His Ser Met Arg Thr Arg Ser Gly Arg Leu Ser Ser Ser Glu Leu Ser 
        755                 760                 765             


Pro Leu Thr Pro Pro Ser Ser Val Ser Ser Ser Leu Ser Ile Ser Val 
    770                 775                 780                 


Ser Pro Leu Ala Thr Ser Ala Leu Asn Pro Thr Phe Thr Phe Pro Ser 
785                 790                 795                 800 


His Ser Leu Thr Gln Ser Gly Glu Ser Ala Glu Lys Asn Gln Arg Pro 
                805                 810                 815     


Arg Lys Gln Thr Ser Ala Pro Ala Glu Pro Phe Ser Ser Ser Ser Pro 
            820                 825                 830         


Thr Pro Leu Phe Pro Trp Phe Thr Pro Gly Ser Gln Thr Glu Arg Gly 
        835                 840                 845             


Arg Asn Lys Asp Lys Ala Pro Glu Glu Leu Ser Lys Asp Arg Asp Ala 
    850                 855                 860                 


Asp Lys Ser Val Glu Lys Asp Lys Ser Arg Glu Arg Asp Arg Glu Arg 
865                 870                 875                 880 


Glu Lys Glu Asn Lys Arg Glu Ser Arg Lys Glu Lys Arg Lys Lys Gly 
                885                 890                 895     


Ser Glu Ile Gln Ser Ser Ser Ala Leu Tyr Pro Val Gly Arg Val Ser 
            900                 905                 910         


Lys Glu Lys Val Val Gly Glu Asp Val Ala Thr Ser Ser Ser Ala Lys 
        915                 920                 925             


Lys Ala Thr Gly Arg Lys Lys Ser Ser Ser His Asp Ser Gly Thr Asp 
    930                 935                 940                 


Ile Thr Ser Val Thr Leu Gly Asp Thr Thr Ala Val Lys Thr Lys Ile 
945                 950                 955                 960 


Leu Ile Lys Lys Gly Arg Gly Asn Leu Glu Lys Thr Asn Leu Asp Leu 
                965                 970                 975     


Gly Pro Thr Ala Pro Ser Leu Glu Lys Glu Lys Thr Leu Cys Leu Ser 
            980                 985                 990         


Thr Pro Ser Ser Ser Thr Val Lys  His Ser Thr Ser Ser  Ile Gly Ser 
        995                 1000                 1005             


Met Leu  Ala Gln Ala Asp Lys  Leu Pro Met Thr Asp  Lys Arg Val 
    1010                 1015                 1020             


Ala Ser  Leu Leu Lys Lys Ala  Lys Ala Gln Leu Cys  Lys Ile Glu 
    1025                 1030                 1035             


Lys Ser  Lys Ser Leu Lys Gln  Thr Asp Gln Pro Lys  Ala Gln Gly 
    1040                 1045                 1050             


Gln Glu  Ser Asp Ser Ser Glu  Thr Ser Val Arg Gly  Pro Arg Ile 
    1055                 1060                 1065             


Lys His  Val Cys Arg Arg Ala  Ala Val Ala Leu Gly  Arg Lys Arg 
    1070                 1075                 1080             


Ala Val  Phe Pro Asp Asp Met  Pro Thr Leu Ser Ala  Leu Pro Trp 
    1085                 1090                 1095             


Glu Glu  Arg Glu Lys Ile Leu  Ser Ser Met Gly Asn  Asp Asp Lys 
    1100                 1105                 1110             


Ser Ser  Ile Ala Gly Ser Glu  Asp Ala Glu Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Ile Lys  Pro Ile Lys Pro Val  Thr Arg Asn Lys Ala  Pro Gln Glu 
    1130                 1135                 1140             


Pro Pro  Val Lys Lys Gly Arg  Arg Ser Arg Arg Cys  Gly Gln Cys 
    1145                 1150                 1155             


Pro Gly  Cys Gln Val Pro Glu  Asp Cys Gly Val Cys  Thr Asn Cys 
    1160                 1165                 1170             


Leu Asp  Lys Pro Lys Phe Gly  Gly Arg Asn Ile Lys  Lys Gln Cys 
    1175                 1180                 1185             


Cys Lys  Met Arg Lys Cys Gln  Asn Leu Gln Trp Met  Pro Ser Lys 
    1190                 1195                 1200             


Ala Tyr  Leu Gln Lys Gln Ala  Lys Ala Val Lys Lys  Lys Glu Lys 
    1205                 1210                 1215             


Lys Ser  Lys Thr Ser Glu Lys  Lys Asp Ser Lys Glu  Ser Ser Val 
    1220                 1225                 1230             


Val Lys  Asn Val Val Asp Ser  Ser Gln Lys Pro Thr  Pro Ser Ala 
    1235                 1240                 1245             


Arg Glu  Asp Pro Ala Pro Lys  Lys Ser Ser Ser Glu  Pro Pro Pro 
    1250                 1255                 1260             


Arg Lys  Pro Val Glu Glu Lys  Ser Glu Glu Gly Asn  Val Ser Ala 
    1265                 1270                 1275             


Pro Gly  Pro Glu Ser Lys Gln  Ala Thr Thr Pro Ala  Ser Arg Lys 
    1280                 1285                 1290             


Ser Ser  Lys Gln Val Ser Gln  Pro Ala Leu Val Ile  Pro Pro Gln 
    1295                 1300                 1305             


Pro Pro  Thr Thr Gly Pro Pro  Arg Lys Glu Val Pro  Lys Thr Thr 
    1310                 1315                 1320             


Pro Ser  Glu Pro Lys Lys Lys  Gln Pro Pro Pro Pro  Glu Ser Gly 
    1325                 1330                 1335             


Pro Glu  Gln Ser Lys Gln Lys  Lys Val Ala Pro Arg  Pro Ser Ile 
    1340                 1345                 1350             


Pro Val  Lys Gln Lys Pro Lys  Glu Lys Glu Lys Pro  Pro Pro Val 
    1355                 1360                 1365             


Asn Lys  Gln Glu Asn Ala Gly  Thr Leu Asn Ile Leu  Ser Thr Leu 
    1370                 1375                 1380             


Ser Asn  Gly Asn Ser Ser Lys  Gln Lys Ile Pro Ala  Asp Gly Val 
    1385                 1390                 1395             


His Arg  Ile Arg Val Asp Phe  Lys Glu Asp Cys Glu  Ala Glu Asn 
    1400                 1405                 1410             


Val Trp  Glu Met Gly Gly Leu  Gly Ile Leu Thr Ser  Val Pro Ile 
    1415                 1420                 1425             


Thr Pro  Arg Val Val Cys Phe  Leu Cys Ala Ser Ser  Gly His Val 
    1430                 1435                 1440             


Glu Phe  Val Tyr Cys Gln Val  Cys Cys Glu Pro Phe  His Lys Phe 
    1445                 1450                 1455             


Cys Leu  Glu Glu Asn Glu Arg  Pro Leu Glu Asp Gln  Leu Glu Asn 
    1460                 1465                 1470             


Trp Cys  Cys Arg Arg Cys Lys  Phe Cys His Val Cys  Gly Arg Gln 
    1475                 1480                 1485             


His Gln  Ala Thr Lys Gln Leu  Leu Glu Cys Asn Lys  Cys Arg Asn 
    1490                 1495                 1500             


Ser Tyr  His Pro Glu Cys Leu  Gly Pro Asn Tyr Pro  Thr Lys Pro 
    1505                 1510                 1515             


Thr Lys  Lys Lys Lys Val Trp  Ile Cys Thr Lys Cys  Val Arg Cys 
    1520                 1525                 1530             


Lys Ser  Cys Gly Ser Thr Thr  Pro Gly Lys Gly Trp  Asp Ala Gln 
    1535                 1540                 1545             


Trp Ser  His Asp Phe Ser Leu  Cys His Asp Cys Ala  Lys Leu Phe 
    1550                 1555                 1560             


Ala Lys  Gly Asn Phe Cys Pro  Leu Cys Asp Lys Cys  Tyr Asp Asp 
    1565                 1570                 1575             


Asp Asp  Tyr Glu Ser Lys Met  Met Gln Cys Gly Lys  Cys Asp Arg 
    1580                 1585                 1590             


Trp Val  His Ser Lys Cys Glu  Asn Leu Ser Gly Thr  Glu Asp Glu 
    1595                 1600                 1605             


Met Tyr  Glu Ile Leu Ser Asn  Leu Pro Glu Ser Val  Ala Tyr Thr 
    1610                 1615                 1620             


Cys Val  Asn Cys Thr Glu Arg  His Pro Ala Glu Trp  Arg Leu Ala 
    1625                 1630                 1635             


Leu Glu  Lys Glu Leu Gln Ile  Ser Leu Lys Gln Val  Leu Thr Ala 
    1640                 1645                 1650             


Leu Leu  Asn Ser Arg Thr Thr  Ser His Leu Leu Arg  Tyr Arg Gln 
    1655                 1660                 1665             


Ala Ala  Lys Pro Pro Asp Leu  Asn Pro Glu Thr Glu  Glu Ser Ile 
    1670                 1675                 1680             


Pro Ser  Arg Ser Ser Pro Glu  Gly Pro Asp Pro Pro  Val Leu Thr 
    1685                 1690                 1695             


Glu Val  Ser Lys Gln Asp Asp  Gln Gln Pro Leu Asp  Leu Glu Gly 
    1700                 1705                 1710             


Val Lys  Arg Lys Met Asp Gln  Gly Asn Tyr Thr Ser  Val Leu Glu 
    1715                 1720                 1725             


Phe Ser  Asp Asp Ile Val Lys  Ile Ile Gln Ala Ala  Ile Asn Ser 
    1730                 1735                 1740             


Asp Gly  Gly Gln Pro Glu Ile  Lys Lys Ala Asn Ser  Met Val Lys 
    1745                 1750                 1755             


Ser Phe  Phe Ile Arg Gln Met  Glu Arg Val Phe Pro  Trp Phe Ser 
    1760                 1765                 1770             


Val Lys  Lys Ser Arg Phe Trp  Glu Pro Asn Lys Val  Ser Ser Asn 
    1775                 1780                 1785             


Ser Gly  Met Leu Pro Asn Ala  Val Leu Pro Pro Ser  Leu Asp His 
    1790                 1795                 1800             


Asn Tyr  Ala Gln Trp Gln Glu  Arg Glu Glu Asn Ser  His Thr Glu 
    1805                 1810                 1815             


Gln Pro  Pro Leu Met Lys Lys  Ile Ile Pro Ala Pro  Lys Pro Lys 
    1820                 1825                 1830             


Gly Pro  Gly Glu Pro Asp Ser  Pro Thr Pro Leu His  Pro Pro Thr 
    1835                 1840                 1845             


Pro Pro  Ile Leu Ser Thr Asp  Arg Ser Arg Glu Asp  Ser Pro Glu 
    1850                 1855                 1860             


Leu Asn  Pro Pro Pro Gly Ile  Glu Asp Asn Arg Gln  Cys Ala Leu 
    1865                 1870                 1875             


Cys Leu  Thr Tyr Gly Asp Asp  Ser Ala Asn Asp Ala  Gly Arg Leu 
    1880                 1885                 1890             


Leu Tyr  Ile Gly Gln Asn Glu  Trp Thr His Val Asn  Cys Ala Leu 
    1895                 1900                 1905             


Trp Ser  Ala Glu Val Phe Glu  Asp Asp Asp Gly Ser  Leu Lys Asn 
    1910                 1915                 1920             


Val His  Met Ala Val Ile Arg  Gly Lys Gln Leu Arg  Cys Glu Phe 
    1925                 1930                 1935             


Cys Gln  Lys Pro Gly Ala Thr  Val Gly Cys Cys Leu  Thr Ser Cys 
    1940                 1945                 1950             


Thr Ser  Asn Tyr His Phe Met  Cys Ser Arg Ala Lys  Asn Cys Val 
    1955                 1960                 1965             


Phe Leu  Asp Asp Lys Lys Val  Tyr Cys Gln Arg His  Arg Asp Leu 
    1970                 1975                 1980             


Ile Lys  Gly Glu Val Val Pro  Glu Asn Gly Phe Glu  Val Phe Arg 
    1985                 1990                 1995             


Arg Val  Phe Val Asp Phe Glu  Gly Ile Ser Leu Arg  Arg Lys Phe 
    2000                 2005                 2010             


Leu Asn  Gly Leu Glu Pro Glu  Asn Ile His Met Met  Ile Gly Ser 
    2015                 2020                 2025             


Met Thr  Ile Asp Cys Leu Gly  Ile Leu Asn Asp Leu  Ser Asp Cys 
    2030                 2035                 2040             


Glu Asp  Lys Leu Phe Pro Ile  Gly Tyr Gln Cys Ser  Arg Val Tyr 
    2045                 2050                 2055             


Trp Ser  Thr Thr Asp Ala Arg  Lys Arg Cys Val Tyr  Thr Cys Lys 
    2060                 2065                 2070             


Ile Val  Glu Cys Arg Pro Pro  Val Val Glu Pro Asp  Ile Asn Ser 
    2075                 2080                 2085             


Thr Val  Glu His Asp Glu Asn  Arg Thr Ile Ala His  Ser Pro Thr 
    2090                 2095                 2100             


Ser Phe  Thr Glu Ser Ser Ser  Lys Glu Ser Gln Asn  Thr Ala Glu 
    2105                 2110                 2115             


Ile Ile  Ser Pro Pro Ser Pro  Asp Arg Pro Pro His  Ser Gln Thr 
    2120                 2125                 2130             


Ser Gly  Ser Cys Tyr Tyr His  Val Ile Ser Lys Val  Pro Arg Ile 
    2135                 2140                 2145             


Arg Thr  Pro Ser Tyr Ser Pro  Thr Gln Arg Ser Pro  Gly Cys Arg 
    2150                 2155                 2160             


Pro Leu  Pro Ser Ala Gly Ser  Pro Thr Pro Thr Thr  His Glu Ile 
    2165                 2170                 2175             


Val Thr  Val Gly Asp Pro Leu  Leu Ser Ser Gly Leu  Arg Ser Ile 
    2180                 2185                 2190             


Gly Ser  Arg Arg His Ser Thr  Ser Ser Leu Ser Pro  Gln Arg Ser 
    2195                 2200                 2205             


Lys Leu  Arg Ile Met Ser Pro  Met Arg Thr Gly Asn  Thr Tyr Ser 
    2210                 2215                 2220             


Arg Asn  Asn Val Ser Ser Val  Ser Thr Thr Gly Thr  Ala Thr Asp 
    2225                 2230                 2235             


Leu Glu  Ser Ser Ala Lys Val  Val Asp His Val Leu  Gly Pro Leu 
    2240                 2245                 2250             


Asn Ser  Ser Thr Ser Leu Gly  Gln Asn Thr Ser Thr  Ser Ser Asn 
    2255                 2260                 2265             


Leu Gln  Arg Thr Val Val Thr  Val Gly Asn Lys Asn  Ser His Leu 
    2270                 2275                 2280             


Asp Gly  Ser Ser Ser Ser Glu  Met Lys Gln Ser Ser  Ala Ser Asp 
    2285                 2290                 2295             


Leu Val  Ser Lys Ser Ser Ser  Leu Lys Gly Glu Lys  Thr Lys Val 
    2300                 2305                 2310             


Leu Ser  Ser Lys Ser Ser Glu  Gly Ser Ala His Asn  Val Ala Tyr 
    2315                 2320                 2325             


Pro Gly  Ile Pro Lys Leu Ala  Pro Gln Val His Asn  Thr Thr Ser 
    2330                 2335                 2340             


Arg Glu  Leu Asn Val Ser Lys  Ile Gly Ser Phe Ala  Glu Pro Ser 
    2345                 2350                 2355             


Ser Val  Ser Phe Ser Ser Lys  Glu Ala Leu Ser Phe  Pro His Leu 
    2360                 2365                 2370             


His Leu  Arg Gly Gln Arg Asn  Asp Arg Asp Gln His  Thr Asp Ser 
    2375                 2380                 2385             


Thr Gln  Ser Ala Asn Ser Ser  Pro Asp Glu Asp Thr  Glu Val Lys 
    2390                 2395                 2400             


Thr Leu  Lys Leu Ser Gly Met  Ser Asn Arg Ser Ser  Ile Ile Asn 
    2405                 2410                 2415             


Glu His  Met Gly Ser Ser Ser  Arg Asp Arg Arg Gln  Lys Gly Lys 
    2420                 2425                 2430             


Lys Ser  Cys Lys Glu Thr Phe  Lys Glu Lys His Ser  Ser Lys Ser 
    2435                 2440                 2445             


Phe Leu  Glu Pro Gly Gln Val  Thr Thr Gly Glu Glu  Gly Asn Leu 
    2450                 2455                 2460             


Lys Pro  Glu Phe Met Asp Glu  Val Leu Thr Pro Glu  Tyr Met Gly 
    2465                 2470                 2475             


Gln Arg  Pro Cys Asn Asn Val  Ser Ser Asp Lys Ile  Gly Asp Lys 
    2480                 2485                 2490             


Gly Leu  Ser Met Pro Gly Val  Pro Lys Ala Pro Pro  Met Gln Val 
    2495                 2500                 2505             


Glu Gly  Ser Ala Lys Glu Leu  Gln Ala Pro Arg Lys  Arg Thr Val 
    2510                 2515                 2520             


Lys Val  Thr Leu Thr Pro Leu  Lys Met Glu Asn Glu  Ser Gln Ser 
    2525                 2530                 2535             


Lys Asn  Ala Leu Lys Glu Ser  Ser Pro Ala Ser Pro  Leu Gln Ile 
    2540                 2545                 2550             


Glu Ser  Thr Ser Pro Thr Glu  Pro Ile Ser Ala Ser  Glu Asn Pro 
    2555                 2560                 2565             


Gly Asp  Gly Pro Val Ala Gln  Pro Ser Pro Asn Asn  Thr Ser Cys 
    2570                 2575                 2580             


Gln Asp  Ser Gln Ser Asn Asn  Tyr Gln Asn Leu Pro  Val Gln Asp 
    2585                 2590                 2595             


Arg Asn  Leu Met Leu Pro Asp  Gly Pro Lys Pro Gln  Glu Asp Gly 
    2600                 2605                 2610             


Ser Phe  Lys Arg Arg Tyr Pro  Arg Arg Ser Ala Arg  Ala Arg Ser 
    2615                 2620                 2625             


Asn Met  Phe Phe Gly Leu Thr  Pro Leu Tyr Gly Val  Arg Ser Tyr 
    2630                 2635                 2640             


Gly Glu  Glu Asp Ile Pro Phe  Tyr Ser Ser Ser Thr  Gly Lys Lys 
    2645                 2650                 2655             


Arg Gly  Lys Arg Ser Ala Glu  Gly Gln Val Asp Gly  Ala Asp Asp 
    2660                 2665                 2670             


Leu Ser  Thr Ser Asp Glu Asp  Asp Leu Tyr Tyr Tyr  Asn Phe Thr 
    2675                 2680                 2685             


Arg Thr  Val Ile Ser Ser Gly  Gly Glu Glu Arg Leu  Ala Ser His 
    2690                 2695                 2700             


Asn Leu  Phe Arg Glu Glu Glu  Gln Cys Asp Leu Pro  Lys Ile Ser 
    2705                 2710                 2715             


Gln Leu  Asp Gly Val Asp Asp  Gly Thr Glu Ser Asp  Thr Ser Val 
    2720                 2725                 2730             


Thr Ala  Thr Thr Arg Lys Ser  Ser Gln Ile Pro Lys  Arg Asn Gly 
    2735                 2740                 2745             


Lys Glu  Asn Gly Thr Glu Asn  Leu Lys Ile Asp Arg  Pro Glu Asp 
    2750                 2755                 2760             


Ala Gly  Glu Lys Glu His Val  Thr Lys Ser Ser Val  Gly His Lys 
    2765                 2770                 2775             


Asn Glu  Pro Lys Met Asp Asn  Cys His Ser Val Ser  Arg Val Lys 
    2780                 2785                 2790             


Thr Gln  Gly Gln Asp Ser Leu  Glu Ala Gln Leu Ser  Ser Leu Glu 
    2795                 2800                 2805             


Ser Ser  Arg Arg Val His Thr  Ser Thr Pro Ser Asp  Lys Asn Leu 
    2810                 2815                 2820             


Leu Asp  Thr Tyr Asn Thr Glu  Leu Leu Lys Ser Asp  Ser Asp Asn 
    2825                 2830                 2835             


Asn Asn  Ser Asp Asp Cys Gly  Asn Ile Leu Pro Ser  Asp Ile Met 
    2840                 2845                 2850             


Asp Phe  Val Leu Lys Asn Thr  Pro Ser Met Gln Ala  Leu Gly Glu 
    2855                 2860                 2865             


Ser Pro  Glu Ser Ser Ser Ser  Glu Leu Leu Asn Leu  Gly Glu Gly 
    2870                 2875                 2880             


Leu Gly  Leu Asp Ser Asn Arg  Glu Lys Asp Met Gly  Leu Phe Glu 
    2885                 2890                 2895             


Val Phe  Ser Gln Gln Leu Pro  Thr Thr Glu Pro Val  Asp Ser Ser 
    2900                 2905                 2910             


Val Ser  Ser Ser Ile Ser Ala  Glu Glu Gln Phe Glu  Leu Pro Leu 
    2915                 2920                 2925             


Glu Leu  Pro Ser Asp Leu Ser  Val Leu Thr Thr Arg  Ser Pro Thr 
    2930                 2935                 2940             


Val Pro  Ser Gln Asn Pro Ser  Arg Leu Ala Val Ile  Ser Asp Ser 
    2945                 2950                 2955             


Gly Glu  Lys Arg Val Thr Ile  Thr Glu Lys Ser Val  Ala Ser Ser 
    2960                 2965                 2970             


Glu Ser  Asp Pro Ala Leu Leu  Ser Pro Gly Val Asp  Pro Thr Pro 
    2975                 2980                 2985             


Glu Gly  His Met Thr Pro Asp  His Phe Ile Gln Gly  His Met Asp 
    2990                 2995                 3000             


Ala Asp  His Ile Ser Ser Pro  Pro Cys Gly Ser Val  Glu Gln Gly 
    3005                 3010                 3015             


His Gly  Asn Asn Gln Asp Leu  Thr Arg Asn Ser Ser  Thr Pro Gly 
    3020                 3025                 3030             


Leu Gln  Val Pro Val Ser Pro  Thr Val Pro Ile Gln  Asn Gln Lys 
    3035                 3040                 3045             


Tyr Val  Pro Asn Ser Thr Asp  Ser Pro Gly Pro Ser  Gln Ile Ser 
    3050                 3055                 3060             


Asn Ala  Ala Val Gln Thr Thr  Pro Pro His Leu Lys  Pro Ala Thr 
    3065                 3070                 3075             


Glu Lys  Leu Ile Val Val Asn  Gln Asn Met Gln Pro  Leu Tyr Val 
    3080                 3085                 3090             


Leu Gln  Thr Leu Pro Asn Gly  Val Thr Gln Lys Ile  Gln Leu Thr 
    3095                 3100                 3105             


Ser Ser  Val Ser Ser Thr Pro  Ser Val Met Glu Thr  Asn Thr Ser 
    3110                 3115                 3120             


Val Leu  Gly Pro Met Gly Gly  Gly Leu Thr Leu Thr  Thr Gly Leu 
    3125                 3130                 3135             


Asn Pro  Ser Leu Pro Thr Ser  Gln Ser Leu Phe Pro  Ser Ala Ser 
    3140                 3145                 3150             


Lys Gly  Leu Leu Pro Met Ser  His His Gln His Leu  His Ser Phe 
    3155                 3160                 3165             


Pro Ala  Ala Thr Gln Ser Ser  Phe Pro Pro Asn Ile  Ser Asn Pro 
    3170                 3175                 3180             


Pro Ser  Gly Leu Leu Ile Gly  Val Gln Pro Pro Pro  Asp Pro Gln 
    3185                 3190                 3195             


Leu Leu  Val Ser Glu Ser Ser  Gln Arg Thr Asp Leu  Ser Thr Thr 
    3200                 3205                 3210             


Val Ala  Thr Pro Ser Ser Gly  Leu Lys Lys Arg Pro  Ile Ser Arg 
    3215                 3220                 3225             


Leu Gln  Thr Arg Lys Asn Lys  Lys Leu Ala Pro Ser  Ser Thr Pro 
    3230                 3235                 3240             


Ser Asn  Ile Ala Pro Ser Asp  Val Val Ser Asn Met  Thr Leu Ile 
    3245                 3250                 3255             


Asn Phe  Thr Pro Ser Gln Leu  Pro Asn His Pro Ser  Leu Leu Asp 
    3260                 3265                 3270             


Leu Gly  Ser Leu Asn Thr Ser  Ser His Arg Thr Val  Pro Asn Ile 
    3275                 3280                 3285             


Ile Lys  Arg Ser Lys Ser Ser  Ile Met Tyr Phe Glu  Pro Ala Pro 
    3290                 3295                 3300             


Leu Leu  Pro Gln Ser Val Gly  Gly Thr Ala Ala Thr  Ala Ala Gly 
    3305                 3310                 3315             


Thr Ser  Thr Ile Ser Gln Asp  Thr Ser His Leu Thr  Ser Gly Ser 
    3320                 3325                 3330             


Val Ser  Gly Leu Ala Ser Ser  Ser Ser Val Leu Asn  Val Val Ser 
    3335                 3340                 3345             


Met Gln  Thr Thr Thr Thr Pro  Thr Ser Ser Ala Ser  Val Pro Gly 
    3350                 3355                 3360             


His Val  Thr Leu Thr Asn Pro  Arg Leu Leu Gly Thr  Pro Asp Ile 
    3365                 3370                 3375             


Gly Ser  Ile Ser Asn Leu Leu  Ile Lys Ala Ser Gln  Gln Ser Leu 
    3380                 3385                 3390             


Gly Ile  Gln Asp Gln Pro Val  Ala Leu Pro Pro Ser  Ser Gly Met 
    3395                 3400                 3405             


Phe Pro  Gln Leu Gly Thr Ser  Gln Thr Pro Ser Thr  Ala Ala Ile 
    3410                 3415                 3420             


Thr Ala  Ala Ser Ser Ile Cys  Val Leu Pro Ser Thr  Gln Thr Thr 
    3425                 3430                 3435             


Gly Ile  Thr Ala Ala Ser Pro  Ser Gly Glu Ala Asp  Glu His Tyr 
    3440                 3445                 3450             


Gln Leu  Gln His Val Asn Gln  Leu Leu Ala Ser Lys  Thr Gly Ile 
    3455                 3460                 3465             


His Ser  Ser Gln Arg Asp Leu  Asp Ser Ala Ser Gly  Pro Gln Val 
    3470                 3475                 3480             


Ser Asn  Phe Thr Gln Thr Val  Asp Ala Pro Asn Ser  Met Gly Leu 
    3485                 3490                 3495             


Glu Gln  Asn Lys Ala Leu Ser  Ser Ala Val Gln Ala  Ser Pro Thr 
    3500                 3505                 3510             


Ser Pro  Gly Gly Ser Pro Ser  Ser Pro Ser Ser Gly  Gln Arg Ser 
    3515                 3520                 3525             


Ala Ser  Pro Ser Val Pro Gly  Pro Thr Lys Pro Lys  Pro Lys Thr 
    3530                 3535                 3540             


Lys Arg  Phe Gln Leu Pro Leu  Asp Lys Gly Asn Gly  Lys Lys His 
    3545                 3550                 3555             


Lys Val  Ser His Leu Arg Thr  Ser Ser Ser Glu Ala  His Ile Pro 
    3560                 3565                 3570             


Asp Gln  Glu Thr Thr Ser Leu  Thr Ser Gly Thr Gly  Thr Pro Gly 
    3575                 3580                 3585             


Ala Glu  Ala Glu Gln Gln Asp  Thr Ala Ser Val Glu  Gln Ser Ser 
    3590                 3595                 3600             


Gln Lys  Glu Cys Gly Gln Pro  Ala Gly Gln Val Ala  Val Leu Pro 
    3605                 3610                 3615             


Glu Val  Gln Val Thr Gln Asn  Pro Ala Asn Glu Gln  Glu Ser Ala 
    3620                 3625                 3630             


Glu Pro  Lys Thr Val Glu Glu  Glu Glu Ser Asn Phe  Ser Ser Pro 
    3635                 3640                 3645             


Leu Met  Leu Trp Leu Gln Gln  Glu Gln Lys Arg Lys  Glu Ser Ile 
    3650                 3655                 3660             


Thr Glu  Lys Lys Pro Lys Lys  Gly Leu Val Phe Glu  Ile Ser Ser 
    3665                 3670                 3675             


Asp Asp  Gly Phe Gln Ile Cys  Ala Glu Ser Ile Glu  Asp Ala Trp 
    3680                 3685                 3690             


Lys Ser  Leu Thr Asp Lys Val  Gln Glu Ala Arg Ser  Asn Ala Arg 
    3695                 3700                 3705             


Leu Lys  Gln Leu Ser Phe Ala  Gly Val Asn Gly Leu  Arg Met Leu 
    3710                 3715                 3720             


Gly Ile  Leu His Asp Ala Val  Val Phe Leu Ile Glu  Gln Leu Ser 
    3725                 3730                 3735             


Gly Ala  Lys His Cys Arg Asn  Tyr Lys Phe Arg Phe  His Lys Pro 
    3740                 3745                 3750             


Glu Glu  Ala Asn Glu Pro Pro  Leu Asn Pro His Gly  Ser Ala Arg 
    3755                 3760                 3765             


Ala Glu  Val His Leu Arg Lys  Ser Ala Phe Asp Met  Phe Asn Phe 
    3770                 3775                 3780             


Leu Ala  Ser Lys His Arg Gln  Pro Pro Glu Tyr Asn  Pro Asn Asp 
    3785                 3790                 3795             


Glu Glu  Glu Glu Glu Val Gln  Leu Lys Ser Ala Arg  Arg Ala Thr 
    3800                 3805                 3810             


Ser Met  Asp Leu Pro Met Pro  Met Arg Phe Arg His  Leu Lys Lys 
    3815                 3820                 3825             


Thr Ser  Lys Glu Ala Val Gly  Val Tyr Arg Ser Pro  Ile His Gly 
    3830                 3835                 3840             


Arg Gly  Leu Phe Cys Lys Arg  Asn Ile Asp Ala Gly  Glu Met Val 
    3845                 3850                 3855             


Ile Glu  Tyr Ala Gly Asn Val  Ile Arg Ser Ile Gln  Thr Asp Lys 
    3860                 3865                 3870             


Arg Glu  Lys Tyr Tyr Asp Ser  Lys Gly Ile Gly Cys  Tyr Met Phe 
    3875                 3880                 3885             


Arg Ile  Asp Asp Ser Glu Val  Val Asp Ala Thr Met  His Gly Asn 
    3890                 3895                 3900             


Ala Ala  Arg Phe Ile Asn His  Ser Cys Glu Pro Asn  Cys Tyr Ser 
    3905                 3910                 3915             


Arg Val  Ile Asn Ile Asp Gly  Gln Lys His Ile Val  Ile Phe Ala 
    3920                 3925                 3930             


Met Arg  Lys Ile Tyr Arg Gly  Glu Glu Leu Thr Tyr  Asp Tyr Lys 
    3935                 3940                 3945             


Phe Pro  Ile Glu Asp Ala Ser  Asn Lys Leu Pro Cys  Asn Cys Gly 
    3950                 3955                 3960             


Ala Lys  Lys Cys Arg Lys Phe  Leu Asn 
    3965                 3970         


<210>  5993
<211>  2715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KMT2B__Homo_sapiens__NP_055542

<400>  5993

Met Ala Ala Ala Ala Gly Gly Gly Ser Cys Pro Gly Pro Gly Ser Ala 
1               5                   10                  15      


Arg Gly Arg Phe Pro Gly Arg Pro Arg Gly Ala Gly Gly Gly Gly Gly 
            20                  25                  30          


Arg Gly Gly Arg Gly Asn Gly Ala Glu Arg Val Arg Val Ala Leu Arg 
        35                  40                  45              


Arg Gly Gly Gly Ala Thr Gly Pro Gly Gly Ala Glu Pro Gly Glu Asp 
    50                  55                  60                  


Thr Ala Leu Leu Arg Leu Leu Gly Leu Arg Arg Gly Leu Arg Arg Leu 
65                  70                  75                  80  


Arg Arg Leu Trp Ala Gly Pro Arg Val Gln Arg Gly Arg Gly Arg Gly 
                85                  90                  95      


Arg Gly Arg Gly Trp Gly Pro Ser Arg Gly Cys Val Pro Glu Glu Glu 
            100                 105                 110         


Ser Ser Asp Gly Glu Ser Asp Glu Glu Glu Phe Gln Gly Phe His Ser 
        115                 120                 125             


Asp Glu Asp Val Ala Pro Ser Ser Leu Arg Ser Ala Leu Arg Ser Gln 
    130                 135                 140                 


Arg Gly Arg Ala Pro Arg Gly Arg Gly Arg Lys His Lys Thr Thr Pro 
145                 150                 155                 160 


Leu Pro Pro Pro Arg Leu Ala Asp Val Ala Pro Thr Pro Pro Lys Thr 
                165                 170                 175     


Pro Ala Arg Lys Arg Gly Glu Glu Gly Thr Glu Arg Met Val Gln Ala 
            180                 185                 190         


Leu Thr Glu Leu Leu Arg Arg Ala Gln Ala Pro Gln Ala Pro Arg Ser 
        195                 200                 205             


Arg Ala Cys Glu Pro Ser Thr Pro Arg Arg Ser Arg Gly Arg Pro Pro 
    210                 215                 220                 


Gly Arg Pro Ala Gly Pro Cys Arg Arg Lys Gln Gln Ala Val Val Val 
225                 230                 235                 240 


Ala Glu Ala Ala Val Thr Ile Pro Lys Pro Glu Pro Pro Pro Pro Val 
                245                 250                 255     


Val Pro Val Lys His Gln Thr Gly Ser Trp Lys Cys Lys Glu Gly Pro 
            260                 265                 270         


Gly Pro Gly Pro Gly Thr Pro Arg Arg Gly Gly Gln Ser Ser Arg Gly 
        275                 280                 285             


Gly Arg Gly Gly Arg Gly Arg Gly Arg Gly Gly Gly Leu Pro Phe Val 
    290                 295                 300                 


Ile Lys Phe Val Ser Arg Ala Lys Lys Val Lys Met Gly Gln Leu Ser 
305                 310                 315                 320 


Leu Gly Leu Glu Ser Gly Gln Gly Gln Gly Gln His Glu Glu Ser Trp 
                325                 330                 335     


Gln Asp Val Pro Gln Arg Arg Val Gly Ser Gly Gln Gly Gly Ser Pro 
            340                 345                 350         


Cys Trp Lys Lys Gln Glu Gln Lys Leu Asp Asp Glu Glu Glu Glu Lys 
        355                 360                 365             


Lys Glu Glu Glu Glu Lys Asp Lys Glu Gly Glu Glu Lys Glu Glu Arg 
    370                 375                 380                 


Ala Val Ala Glu Glu Met Met Pro Ala Ala Glu Lys Glu Glu Ala Lys 
385                 390                 395                 400 


Leu Pro Pro Pro Pro Leu Thr Pro Pro Ala Pro Ser Pro Pro Pro Pro 
                405                 410                 415     


Leu Pro Pro Pro Ser Thr Ser Pro Pro Pro Pro Leu Cys Pro Pro Pro 
            420                 425                 430         


Pro Pro Pro Val Ser Pro Pro Pro Leu Pro Ser Pro Pro Pro Pro Pro 
        435                 440                 445             


Ala Gln Glu Glu Gln Glu Glu Ser Pro Pro Pro Val Val Pro Ala Thr 
    450                 455                 460                 


Cys Ser Arg Lys Arg Gly Arg Pro Pro Leu Thr Pro Ser Gln Arg Ala 
465                 470                 475                 480 


Glu Arg Glu Ala Ala Arg Ala Gly Pro Glu Gly Thr Ser Pro Pro Thr 
                485                 490                 495     


Pro Thr Pro Ser Thr Ala Thr Gly Gly Pro Pro Glu Asp Ser Pro Thr 
            500                 505                 510         


Val Ala Pro Lys Ser Thr Thr Phe Leu Lys Asn Ile Arg Gln Phe Ile 
        515                 520                 525             


Met Pro Val Val Ser Ala Arg Ser Ser Arg Val Ile Lys Thr Pro Arg 
    530                 535                 540                 


Arg Phe Met Asp Glu Asp Pro Pro Lys Pro Pro Lys Val Glu Val Ser 
545                 550                 555                 560 


Pro Val Leu Arg Pro Pro Ile Thr Thr Ser Pro Pro Val Pro Gln Glu 
                565                 570                 575     


Pro Ala Pro Val Pro Ser Pro Pro Arg Ala Pro Thr Pro Pro Ser Thr 
            580                 585                 590         


Pro Val Pro Leu Pro Glu Lys Arg Arg Ser Ile Leu Arg Glu Pro Thr 
        595                 600                 605             


Phe Arg Trp Thr Ser Leu Thr Arg Glu Leu Pro Pro Pro Pro Pro Ala 
    610                 615                 620                 


Pro Pro Pro Pro Pro Ala Pro Ser Pro Pro Pro Ala Pro Ala Thr Ser 
625                 630                 635                 640 


Ser Arg Arg Pro Leu Leu Leu Arg Ala Pro Gln Phe Thr Pro Ser Glu 
                645                 650                 655     


Ala His Leu Lys Ile Tyr Glu Ser Val Leu Thr Pro Pro Pro Leu Gly 
            660                 665                 670         


Ala Pro Glu Ala Pro Glu Pro Glu Pro Pro Pro Ala Asp Asp Ser Pro 
        675                 680                 685             


Ala Glu Pro Glu Pro Arg Ala Val Gly Arg Thr Asn His Leu Ser Leu 
    690                 695                 700                 


Pro Arg Phe Ala Pro Val Val Thr Thr Pro Val Lys Ala Glu Val Ser 
705                 710                 715                 720 


Pro His Gly Ala Pro Ala Leu Ser Asn Gly Pro Gln Thr Gln Ala Gln 
                725                 730                 735     


Leu Leu Gln Pro Leu Gln Ala Leu Gln Thr Gln Leu Leu Pro Gln Ala 
            740                 745                 750         


Leu Pro Pro Pro Gln Pro Gln Leu Gln Pro Pro Pro Ser Pro Gln Gln 
        755                 760                 765             


Met Pro Pro Leu Glu Lys Ala Arg Ile Ala Gly Val Gly Ser Leu Pro 
    770                 775                 780                 


Leu Ser Gly Val Glu Glu Lys Met Phe Ser Leu Leu Lys Arg Ala Lys 
785                 790                 795                 800 


Val Gln Leu Phe Lys Ile Asp Gln Gln Gln Gln Gln Lys Val Ala Ala 
                805                 810                 815     


Ser Met Pro Leu Ser Pro Gly Gly Gln Met Glu Glu Val Ala Gly Ala 
            820                 825                 830         


Val Lys Gln Ile Ser Asp Arg Gly Pro Val Arg Ser Glu Asp Glu Ser 
        835                 840                 845             


Val Glu Ala Lys Arg Glu Arg Pro Ser Gly Pro Glu Ser Pro Val Gln 
    850                 855                 860                 


Gly Pro Arg Ile Lys His Val Cys Arg His Ala Ala Val Ala Leu Gly 
865                 870                 875                 880 


Gln Ala Arg Ala Met Val Pro Glu Asp Val Pro Arg Leu Ser Ala Leu 
                885                 890                 895     


Pro Leu Arg Asp Arg Gln Asp Leu Ala Thr Glu Asp Thr Ser Ser Ala 
            900                 905                 910         


Ser Glu Thr Glu Ser Val Pro Ser Arg Ser Arg Arg Gly Lys Val Glu 
        915                 920                 925             


Ala Ala Gly Pro Gly Gly Glu Ser Glu Pro Thr Gly Ser Gly Gly Thr 
    930                 935                 940                 


Leu Ala His Thr Pro Arg Arg Ser Leu Pro Ser His His Gly Lys Lys 
945                 950                 955                 960 


Met Arg Met Ala Arg Cys Gly His Cys Arg Gly Cys Leu Arg Val Gln 
                965                 970                 975     


Asp Cys Gly Ser Cys Val Asn Cys Leu Asp Lys Pro Lys Phe Gly Gly 
            980                 985                 990         


Pro Asn Thr Lys Lys Gln Cys Cys  Val Tyr Arg Lys Cys  Asp Lys Ile 
        995                 1000                 1005             


Glu Ala  Arg Lys Met Glu Arg  Leu Ala Lys Lys Gly  Arg Thr Ile 
    1010                 1015                 1020             


Val Lys  Thr Leu Leu Pro Trp  Asp Ser Asp Glu Ser  Pro Glu Ala 
    1025                 1030                 1035             


Ser Pro  Gly Pro Pro Gly Pro  Arg Arg Gly Ala Gly  Ala Gly Gly 
    1040                 1045                 1050             


Pro Arg  Glu Glu Val Val Ala  His Pro Gly Pro Glu  Glu Gln Asp 
    1055                 1060                 1065             


Ser Leu  Leu Gln Arg Lys Ser  Ala Arg Arg Cys Val  Lys Gln Arg 
    1070                 1075                 1080             


Pro Ser  Tyr Asp Ile Phe Glu  Asp Ser Asp Asp Ser  Glu Pro Gly 
    1085                 1090                 1095             


Gly Pro  Pro Ala Pro Arg Arg  Arg Thr Pro Arg Glu  Asn Glu Leu 
    1100                 1105                 1110             


Pro Leu  Pro Glu Pro Glu Glu  Gln Ser Arg Pro Arg  Lys Pro Thr 
    1115                 1120                 1125             


Leu Gln  Pro Val Leu Gln Leu  Lys Ala Arg Arg Arg  Leu Asp Lys 
    1130                 1135                 1140             


Asp Ala  Leu Ala Pro Gly Pro  Phe Ala Ser Phe Pro  Asn Gly Trp 
    1145                 1150                 1155             


Thr Gly  Lys Gln Lys Ser Pro  Asp Gly Val His Arg  Val Arg Val 
    1160                 1165                 1170             


Asp Phe  Lys Glu Asp Cys Asp  Leu Glu Asn Val Trp  Leu Met Gly 
    1175                 1180                 1185             


Gly Leu  Ser Val Leu Thr Ser  Val Pro Gly Gly Pro  Pro Met Val 
    1190                 1195                 1200             


Cys Leu  Leu Cys Ala Ser Lys  Gly Leu His Glu Leu  Val Phe Cys 
    1205                 1210                 1215             


Gln Val  Cys Cys Asp Pro Phe  His Pro Phe Cys Leu  Glu Glu Ala 
    1220                 1225                 1230             


Glu Arg  Pro Leu Pro Gln His  His Asp Thr Trp Cys  Cys Arg Arg 
    1235                 1240                 1245             


Cys Lys  Phe Cys His Val Cys  Gly Arg Lys Gly Arg  Gly Ser Lys 
    1250                 1255                 1260             


His Leu  Leu Glu Cys Glu Arg  Cys Arg His Ala Tyr  His Pro Ala 
    1265                 1270                 1275             


Cys Leu  Gly Pro Ser Tyr Pro  Thr Arg Ala Thr Arg  Lys Arg Arg 
    1280                 1285                 1290             


His Trp  Ile Cys Ser Ala Cys  Val Arg Cys Lys Ser  Cys Gly Ala 
    1295                 1300                 1305             


Thr Pro  Gly Lys Asn Trp Asp  Val Glu Trp Ser Gly  Asp Tyr Ser 
    1310                 1315                 1320             


Leu Cys  Pro Arg Cys Thr Gln  Leu Tyr Glu Lys Gly  Asn Tyr Cys 
    1325                 1330                 1335             


Pro Ile  Cys Thr Arg Cys Tyr  Glu Asp Asn Asp Tyr  Glu Ser Lys 
    1340                 1345                 1350             


Met Met  Gln Cys Ala Gln Cys  Asp His Trp Val His  Ala Lys Cys 
    1355                 1360                 1365             


Glu Gly  Leu Ser Asp Glu Asp  Tyr Glu Ile Leu Ser  Gly Leu Pro 
    1370                 1375                 1380             


Asp Ser  Val Leu Tyr Thr Cys  Gly Pro Cys Ala Gly  Ala Ala Gln 
    1385                 1390                 1395             


Pro Arg  Trp Arg Glu Ala Leu  Ser Gly Ala Leu Gln  Gly Gly Leu 
    1400                 1405                 1410             


Arg Gln  Val Leu Gln Gly Leu  Leu Ser Ser Lys Val  Val Gly Pro 
    1415                 1420                 1425             


Leu Leu  Leu Cys Thr Gln Cys  Gly Pro Asp Gly Lys  Gln Leu His 
    1430                 1435                 1440             


Pro Gly  Pro Cys Gly Leu Gln  Ala Val Ser Gln Arg  Phe Glu Asp 
    1445                 1450                 1455             


Gly His  Tyr Lys Ser Val His  Ser Phe Met Glu Asp  Met Val Gly 
    1460                 1465                 1470             


Ile Leu  Met Arg His Ser Glu  Glu Gly Glu Thr Pro  Asp Arg Arg 
    1475                 1480                 1485             


Ala Gly  Gly Gln Met Lys Gly  Leu Leu Leu Lys Leu  Leu Glu Ser 
    1490                 1495                 1500             


Ala Phe  Gly Trp Phe Asp Ala  His Asp Pro Lys Tyr  Trp Arg Arg 
    1505                 1510                 1515             


Ser Thr  Arg Leu Pro Asn Gly  Val Leu Pro Asn Ala  Val Leu Pro 
    1520                 1525                 1530             


Pro Ser  Leu Asp His Val Tyr  Ala Gln Trp Arg Gln  Gln Glu Pro 
    1535                 1540                 1545             


Glu Thr  Pro Glu Ser Gly Gln  Pro Pro Gly Asp Pro  Ser Ala Ala 
    1550                 1555                 1560             


Phe Gln  Gly Lys Asp Pro Ala  Ala Phe Ser His Leu  Glu Asp Pro 
    1565                 1570                 1575             


Arg Gln  Cys Ala Leu Cys Leu  Lys Tyr Gly Asp Ala  Asp Ser Lys 
    1580                 1585                 1590             


Glu Ala  Gly Arg Leu Leu Tyr  Ile Gly Gln Asn Glu  Trp Thr His 
    1595                 1600                 1605             


Val Asn  Cys Ala Ile Trp Ser  Ala Glu Val Phe Glu  Glu Asn Asp 
    1610                 1615                 1620             


Gly Ser  Leu Lys Asn Val His  Ala Ala Val Ala Arg  Gly Arg Gln 
    1625                 1630                 1635             


Met Arg  Cys Glu Leu Cys Leu  Lys Pro Gly Ala Thr  Val Gly Cys 
    1640                 1645                 1650             


Cys Leu  Ser Ser Cys Leu Ser  Asn Phe His Phe Met  Cys Ala Arg 
    1655                 1660                 1665             


Ala Ser  Tyr Cys Ile Phe Gln  Asp Asp Lys Lys Val  Phe Cys Gln 
    1670                 1675                 1680             


Lys His  Thr Asp Leu Leu Asp  Gly Lys Glu Ile Val  Asn Pro Asp 
    1685                 1690                 1695             


Gly Phe  Asp Val Leu Arg Arg  Val Tyr Val Asp Phe  Glu Gly Ile 
    1700                 1705                 1710             


Asn Phe  Lys Arg Lys Phe Leu  Thr Gly Leu Glu Pro  Asp Ala Ile 
    1715                 1720                 1725             


Asn Val  Leu Ile Gly Ser Ile  Arg Ile Asp Ser Leu  Gly Thr Leu 
    1730                 1735                 1740             


Ser Asp  Leu Ser Asp Cys Glu  Gly Arg Leu Phe Pro  Ile Gly Tyr 
    1745                 1750                 1755             


Gln Cys  Ser Arg Leu Tyr Trp  Ser Thr Val Asp Ala  Arg Arg Arg 
    1760                 1765                 1770             


Cys Trp  Tyr Arg Cys Arg Ile  Leu Glu Tyr Arg Pro  Trp Gly Pro 
    1775                 1780                 1785             


Arg Glu  Glu Pro Ala His Leu  Glu Ala Ala Glu Glu  Asn Gln Thr 
    1790                 1795                 1800             


Ile Val  His Ser Pro Ala Pro  Ser Ser Glu Pro Pro  Gly Gly Glu 
    1805                 1810                 1815             


Asp Pro  Pro Leu Asp Thr Asp  Val Leu Val Pro Gly  Ala Pro Glu 
    1820                 1825                 1830             


Arg His  Ser Pro Ile Gln Asn  Leu Asp Pro Pro Leu  Arg Pro Asp 
    1835                 1840                 1845             


Ser Gly  Ser Ala Pro Pro Pro  Ala Pro Arg Ser Phe  Ser Gly Ala 
    1850                 1855                 1860             


Arg Ile  Lys Val Pro Asn Tyr  Ser Pro Ser Arg Arg  Pro Leu Gly 
    1865                 1870                 1875             


Gly Val  Ser Phe Gly Pro Leu  Pro Ser Pro Gly Ser  Pro Ser Ser 
    1880                 1885                 1890             


Leu Thr  His His Ile Pro Thr  Val Gly Asp Pro Asp  Phe Pro Ala 
    1895                 1900                 1905             


Pro Pro  Arg Arg Ser Arg Arg  Pro Ser Pro Leu Ala  Pro Arg Pro 
    1910                 1915                 1920             


Pro Pro  Ser Arg Trp Ala Ser  Pro Pro Leu Lys Thr  Ser Pro Gln 
    1925                 1930                 1935             


Leu Arg  Val Pro Pro Pro Thr  Ser Val Val Thr Ala  Leu Thr Pro 
    1940                 1945                 1950             


Thr Ser  Gly Glu Leu Ala Pro  Pro Gly Pro Ala Pro  Ser Pro Pro 
    1955                 1960                 1965             


Pro Pro  Glu Asp Leu Gly Pro  Asp Phe Glu Asp Met  Glu Val Val 
    1970                 1975                 1980             


Ser Gly  Leu Ser Ala Ala Asp  Leu Asp Phe Ala Ala  Ser Leu Leu 
    1985                 1990                 1995             


Gly Thr  Glu Pro Phe Gln Glu  Glu Ile Val Ala Ala  Gly Ala Met 
    2000                 2005                 2010             


Gly Ser  Ser His Gly Gly Pro  Gly Asp Ser Ser Glu  Glu Glu Ser 
    2015                 2020                 2025             


Ser Pro  Thr Ser Arg Tyr Ile  His Phe Pro Val Thr  Val Val Ser 
    2030                 2035                 2040             


Ala Pro  Gly Leu Ala Pro Ser  Ala Thr Pro Gly Ala  Pro Arg Ile 
    2045                 2050                 2055             


Glu Gln  Leu Asp Gly Val Asp  Asp Gly Thr Asp Ser  Glu Ala Glu 
    2060                 2065                 2070             


Ala Val  Gln Gln Pro Arg Gly  Gln Gly Thr Pro Pro  Ser Gly Pro 
    2075                 2080                 2085             


Gly Val  Val Arg Ala Gly Val  Leu Gly Ala Ala Gly  Asp Arg Ala 
    2090                 2095                 2100             


Arg Pro  Pro Glu Asp Leu Pro  Ser Glu Ile Val Asp  Phe Val Leu 
    2105                 2110                 2115             


Lys Asn  Leu Gly Gly Pro Gly  Asp Gly Gly Ala Gly  Pro Arg Glu 
    2120                 2125                 2130             


Glu Ser  Leu Pro Pro Ala Pro  Pro Leu Ala Asn Gly  Ser Gln Pro 
    2135                 2140                 2145             


Ser Gln  Gly Leu Thr Ala Ser  Pro Ala Asp Pro Thr  Arg Thr Phe 
    2150                 2155                 2160             


Ala Trp  Leu Pro Gly Ala Pro  Gly Val Arg Val Leu  Ser Leu Gly 
    2165                 2170                 2175             


Pro Ala  Pro Glu Pro Pro Lys  Pro Ala Thr Ser Lys  Ile Ile Leu 
    2180                 2185                 2190             


Val Asn  Lys Leu Gly Gln Val  Phe Val Lys Met Ala  Gly Glu Gly 
    2195                 2200                 2205             


Glu Pro  Val Pro Pro Pro Val  Lys Gln Pro Pro Leu  Pro Pro Thr 
    2210                 2215                 2220             


Ile Ser  Pro Thr Ala Pro Thr  Ser Trp Thr Leu Pro  Pro Gly Pro 
    2225                 2230                 2235             


Leu Leu  Gly Val Leu Pro Val  Val Gly Val Val Arg  Pro Ala Pro 
    2240                 2245                 2250             


Pro Pro  Pro Pro Pro Pro Leu  Thr Leu Val Leu Ser  Ser Gly Pro 
    2255                 2260                 2265             


Ala Ser  Pro Pro Arg Gln Ala  Ile Arg Val Lys Arg  Val Ser Thr 
    2270                 2275                 2280             


Phe Ser  Gly Arg Ser Pro Pro  Ala Pro Pro Pro Tyr  Lys Ala Pro 
    2285                 2290                 2295             


Arg Leu  Asp Glu Asp Gly Glu  Ala Ser Glu Asp Thr  Pro Gln Val 
    2300                 2305                 2310             


Pro Gly  Leu Gly Ser Gly Gly  Phe Ser Arg Val Arg  Met Lys Thr 
    2315                 2320                 2325             


Pro Thr  Val Arg Gly Val Leu  Asp Leu Asp Arg Pro  Gly Glu Pro 
    2330                 2335                 2340             


Ala Gly  Glu Glu Ser Pro Gly  Pro Leu Gln Glu Arg  Ser Pro Leu 
    2345                 2350                 2355             


Leu Pro  Leu Pro Glu Asp Gly  Pro Pro Gln Val Pro  Asp Gly Pro 
    2360                 2365                 2370             


Pro Asp  Leu Leu Leu Glu Ser  Gln Trp His His Tyr  Ser Gly Glu 
    2375                 2380                 2385             


Ala Ser  Ser Ser Glu Glu Glu  Pro Pro Ser Pro Asp  Asp Lys Glu 
    2390                 2395                 2400             


Asn Gln  Ala Pro Lys Arg Thr  Gly Pro His Leu Arg  Phe Glu Ile 
    2405                 2410                 2415             


Ser Ser  Glu Asp Gly Phe Ser  Val Glu Ala Glu Ser  Leu Glu Gly 
    2420                 2425                 2430             


Ala Trp  Arg Thr Leu Ile Glu  Lys Val Gln Glu Ala  Arg Gly His 
    2435                 2440                 2445             


Ala Arg  Leu Arg His Leu Ser  Phe Ser Gly Met Ser  Gly Ala Arg 
    2450                 2455                 2460             


Leu Leu  Gly Ile His His Asp  Ala Val Ile Phe Leu  Ala Glu Gln 
    2465                 2470                 2475             


Leu Pro  Gly Ala Gln Arg Cys  Gln His Tyr Lys Phe  Arg Tyr His 
    2480                 2485                 2490             


Gln Gln  Gly Glu Gly Gln Glu  Glu Pro Pro Leu Asn  Pro His Gly 
    2495                 2500                 2505             


Ala Ala  Arg Ala Glu Val Tyr  Leu Arg Lys Cys Thr  Phe Asp Met 
    2510                 2515                 2520             


Phe Asn  Phe Leu Ala Ser Gln  His Arg Val Leu Pro  Glu Gly Ala 
    2525                 2530                 2535             


Thr Cys  Asp Glu Glu Glu Asp  Glu Val Gln Leu Arg  Ser Thr Arg 
    2540                 2545                 2550             


Arg Ala  Thr Ser Leu Glu Leu  Pro Met Ala Met Arg  Phe Arg His 
    2555                 2560                 2565             


Leu Lys  Lys Thr Ser Lys Glu  Ala Val Gly Val Tyr  Arg Ser Ala 
    2570                 2575                 2580             


Ile His  Gly Arg Gly Leu Phe  Cys Lys Arg Asn Ile  Asp Ala Gly 
    2585                 2590                 2595             


Glu Met  Val Ile Glu Tyr Ser  Gly Ile Val Ile Arg  Ser Val Leu 
    2600                 2605                 2610             


Thr Asp  Lys Arg Glu Lys Phe  Tyr Asp Gly Lys Gly  Ile Gly Cys 
    2615                 2620                 2625             


Tyr Met  Phe Arg Met Asp Asp  Phe Asp Val Val Asp  Ala Thr Met 
    2630                 2635                 2640             


His Gly  Asn Ala Ala Arg Phe  Ile Asn His Ser Cys  Glu Pro Asn 
    2645                 2650                 2655             


Cys Phe  Ser Arg Val Ile His  Val Glu Gly Gln Lys  His Ile Val 
    2660                 2665                 2670             


Ile Phe  Ala Leu Arg Arg Ile  Leu Arg Gly Glu Glu  Leu Thr Tyr 
    2675                 2680                 2685             


Asp Tyr  Lys Phe Pro Ile Glu  Asp Ala Ser Asn Lys  Leu Pro Cys 
    2690                 2695                 2700             


Asn Cys  Gly Ala Lys Arg Cys  Arg Arg Phe Leu Asn  
    2705                 2710                 2715 


<210>  5994
<211>  4911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KMT2C__Homo_sapiens__NP_733751

<400>  5994

Met Ser Ser Glu Glu Asp Lys Ser Val Glu Gln Pro Gln Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Gly Ala Pro Ala Pro Ser Pro Ala Ala Ala 
            20                  25                  30          


Asp Lys Arg Pro Arg Gly Arg Pro Arg Lys Asp Gly Ala Ser Pro Phe 
        35                  40                  45              


Gln Arg Ala Arg Lys Lys Pro Arg Ser Arg Gly Lys Thr Ala Val Glu 
    50                  55                  60                  


Asp Glu Asp Ser Met Asp Gly Leu Glu Thr Thr Glu Thr Glu Thr Ile 
65                  70                  75                  80  


Val Glu Thr Glu Ile Lys Glu Gln Ser Ala Glu Glu Asp Ala Glu Ala 
                85                  90                  95      


Glu Val Asp Asn Ser Lys Gln Leu Ile Pro Thr Leu Gln Arg Ser Val 
            100                 105                 110         


Ser Glu Glu Ser Ala Asn Ser Leu Val Ser Val Gly Val Glu Ala Lys 
        115                 120                 125             


Ile Ser Glu Gln Leu Cys Ala Phe Cys Tyr Cys Gly Glu Lys Ser Ser 
    130                 135                 140                 


Leu Gly Gln Gly Asp Leu Lys Gln Phe Arg Ile Thr Pro Gly Phe Ile 
145                 150                 155                 160 


Leu Pro Trp Arg Asn Gln Pro Ser Asn Lys Lys Asp Ile Asp Asp Asn 
                165                 170                 175     


Ser Asn Gly Thr Tyr Glu Lys Met Gln Asn Ser Ala Pro Arg Lys Gln 
            180                 185                 190         


Arg Gly Gln Arg Lys Glu Arg Ser Pro Gln Gln Asn Ile Val Ser Cys 
        195                 200                 205             


Val Ser Val Ser Thr Gln Thr Ala Ser Asp Asp Gln Ala Gly Lys Leu 
    210                 215                 220                 


Trp Asp Glu Leu Ser Leu Val Gly Leu Pro Asp Ala Ile Asp Ile Gln 
225                 230                 235                 240 


Ala Leu Phe Asp Ser Thr Gly Thr Cys Trp Ala His His Arg Cys Val 
                245                 250                 255     


Glu Trp Ser Leu Gly Val Cys Gln Met Glu Glu Pro Leu Leu Val Asn 
            260                 265                 270         


Val Asp Lys Ala Val Val Ser Gly Ser Thr Glu Arg Cys Ala Phe Cys 
        275                 280                 285             


Lys His Leu Gly Ala Thr Ile Lys Cys Cys Glu Glu Lys Cys Thr Gln 
    290                 295                 300                 


Met Tyr His Tyr Pro Cys Ala Ala Gly Ala Gly Thr Phe Gln Asp Phe 
305                 310                 315                 320 


Ser His Ile Phe Leu Leu Cys Pro Glu His Ile Asp Gln Ala Pro Glu 
                325                 330                 335     


Arg Ser Lys Glu Asp Ala Asn Cys Ala Val Cys Asp Ser Pro Gly Asp 
            340                 345                 350         


Leu Leu Asp Gln Phe Phe Cys Thr Thr Cys Gly Gln His Tyr His Gly 
        355                 360                 365             


Met Cys Leu Asp Ile Ala Val Thr Pro Leu Lys Arg Ala Gly Trp Gln 
    370                 375                 380                 


Cys Pro Glu Cys Lys Val Cys Gln Asn Cys Lys Gln Ser Gly Glu Asp 
385                 390                 395                 400 


Ser Lys Met Leu Val Cys Asp Thr Cys Asp Lys Gly Tyr His Thr Phe 
                405                 410                 415     


Cys Leu Gln Pro Val Met Lys Ser Val Pro Thr Asn Gly Trp Lys Cys 
            420                 425                 430         


Lys Asn Cys Arg Ile Cys Ile Glu Cys Gly Thr Arg Ser Ser Ser Gln 
        435                 440                 445             


Trp His His Asn Cys Leu Ile Cys Asp Asn Cys Tyr Gln Gln Gln Asp 
    450                 455                 460                 


Asn Leu Cys Pro Phe Cys Gly Lys Cys Tyr His Pro Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Met Leu His Cys Asn Met Cys Lys Arg Trp Val His Leu Glu Cys 
                485                 490                 495     


Asp Lys Pro Thr Asp His Glu Leu Asp Thr Gln Leu Lys Glu Glu Tyr 
            500                 505                 510         


Ile Cys Met Tyr Cys Lys His Leu Gly Ala Glu Met Asp Arg Leu Gln 
        515                 520                 525             


Pro Gly Glu Glu Val Glu Ile Ala Glu Leu Thr Thr Asp Tyr Asn Asn 
    530                 535                 540                 


Glu Met Glu Val Glu Gly Pro Glu Asp Gln Met Val Phe Ser Glu Gln 
545                 550                 555                 560 


Ala Ala Asn Lys Asp Val Asn Gly Gln Glu Ser Thr Pro Gly Ile Val 
                565                 570                 575     


Pro Asp Ala Val Gln Val His Thr Glu Glu Gln Gln Lys Ser His Pro 
            580                 585                 590         


Ser Glu Ser Leu Asp Thr Asp Ser Leu Leu Ile Ala Val Ser Ser Gln 
        595                 600                 605             


His Thr Val Asn Thr Glu Leu Glu Lys Gln Ile Ser Asn Glu Val Asp 
    610                 615                 620                 


Ser Glu Asp Leu Lys Met Ser Ser Glu Val Lys His Ile Cys Gly Glu 
625                 630                 635                 640 


Asp Gln Ile Glu Asp Lys Met Glu Val Thr Glu Asn Ile Glu Val Val 
                645                 650                 655     


Thr His Gln Ile Thr Val Gln Gln Glu Gln Leu Gln Leu Leu Glu Glu 
            660                 665                 670         


Pro Glu Thr Val Val Ser Arg Glu Glu Ser Arg Pro Pro Lys Leu Val 
        675                 680                 685             


Met Glu Ser Val Thr Leu Pro Leu Glu Thr Leu Val Ser Pro His Glu 
    690                 695                 700                 


Glu Ser Ile Ser Leu Cys Pro Glu Glu Gln Leu Val Ile Glu Arg Leu 
705                 710                 715                 720 


Gln Gly Glu Lys Glu Gln Lys Glu Asn Ser Glu Leu Ser Thr Gly Leu 
                725                 730                 735     


Met Asp Ser Glu Met Thr Pro Thr Ile Glu Gly Cys Val Lys Asp Val 
            740                 745                 750         


Ser Tyr Gln Gly Gly Lys Ser Ile Lys Leu Ser Ser Glu Thr Glu Ser 
        755                 760                 765             


Ser Phe Ser Ser Ser Ala Asp Ile Ser Lys Ala Asp Val Ser Ser Ser 
    770                 775                 780                 


Pro Thr Pro Ser Ser Asp Leu Pro Ser His Asp Met Leu His Asn Tyr 
785                 790                 795                 800 


Pro Ser Ala Leu Ser Ser Ser Ala Gly Asn Ile Met Pro Thr Thr Tyr 
                805                 810                 815     


Ile Ser Val Thr Pro Lys Ile Gly Met Gly Lys Pro Ala Ile Thr Lys 
            820                 825                 830         


Arg Lys Phe Ser Pro Gly Arg Pro Arg Ser Lys Gln Gly Ala Trp Ser 
        835                 840                 845             


Thr His Asn Thr Val Ser Pro Pro Ser Trp Ser Pro Asp Ile Ser Glu 
    850                 855                 860                 


Gly Arg Glu Ile Phe Lys Pro Arg Gln Leu Pro Gly Ser Ala Ile Trp 
865                 870                 875                 880 


Ser Ile Lys Val Gly Arg Gly Ser Gly Phe Pro Gly Lys Arg Arg Pro 
                885                 890                 895     


Arg Gly Ala Gly Leu Ser Gly Arg Gly Gly Arg Gly Arg Ser Lys Leu 
            900                 905                 910         


Lys Ser Gly Ile Gly Ala Val Val Leu Pro Gly Val Ser Thr Ala Asp 
        915                 920                 925             


Ile Ser Ser Asn Lys Asp Asp Glu Glu Asn Ser Met His Asn Thr Val 
    930                 935                 940                 


Val Leu Phe Ser Ser Ser Asp Lys Phe Thr Leu Asn Gln Asp Met Cys 
945                 950                 955                 960 


Val Val Cys Gly Ser Phe Gly Gln Gly Ala Glu Gly Arg Leu Leu Ala 
                965                 970                 975     


Cys Ser Gln Cys Gly Gln Cys Tyr His Pro Tyr Cys Val Ser Ile Lys 
            980                 985                 990         


Ile Thr Lys Val Val Leu Ser Lys  Gly Trp Arg Cys Leu  Glu Cys Thr 
        995                 1000                 1005             


Val Cys  Glu Ala Cys Gly Lys  Ala Thr Asp Pro Gly  Arg Leu Leu 
    1010                 1015                 1020             


Leu Cys  Asp Asp Cys Asp Ile  Ser Tyr His Thr Tyr  Cys Leu Asp 
    1025                 1030                 1035             


Pro Pro  Leu Gln Thr Val Pro  Lys Gly Gly Trp Lys  Cys Lys Trp 
    1040                 1045                 1050             


Cys Val  Trp Cys Arg His Cys  Gly Ala Thr Ser Ala  Gly Leu Arg 
    1055                 1060                 1065             


Cys Glu  Trp Gln Asn Asn Tyr  Thr Gln Cys Ala Pro  Cys Ala Ser 
    1070                 1075                 1080             


Leu Ser  Ser Cys Pro Val Cys  Tyr Arg Asn Tyr Arg  Glu Glu Asp 
    1085                 1090                 1095             


Leu Ile  Leu Gln Cys Arg Gln  Cys Asp Arg Trp Met  His Ala Val 
    1100                 1105                 1110             


Cys Gln  Asn Leu Asn Thr Glu  Glu Glu Val Glu Asn  Val Ala Asp 
    1115                 1120                 1125             


Ile Gly  Phe Asp Cys Ser Met  Cys Arg Pro Tyr Met  Pro Ala Ser 
    1130                 1135                 1140             


Asn Val  Pro Ser Ser Asp Cys  Cys Glu Ser Ser Leu  Val Ala Gln 
    1145                 1150                 1155             


Ile Val  Thr Lys Val Lys Glu  Leu Asp Pro Pro Lys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Asp  Gly Val Cys Leu Thr  Glu Ser Gly Met Thr  Gln Leu Gln 
    1175                 1180                 1185             


Ser Leu  Thr Val Thr Val Pro  Arg Arg Lys Arg Ser  Lys Pro Lys 
    1190                 1195                 1200             


Leu Lys  Leu Lys Ile Ile Asn  Gln Asn Ser Val Ala  Val Leu Gln 
    1205                 1210                 1215             


Thr Pro  Pro Asp Ile Gln Ser  Glu His Ser Arg Asp  Gly Glu Met 
    1220                 1225                 1230             


Asp Asp  Ser Arg Glu Gly Glu  Leu Met Asp Cys Asp  Gly Lys Ser 
    1235                 1240                 1245             


Glu Ser  Ser Pro Glu Arg Glu  Ala Val Asp Asp Glu  Thr Lys Gly 
    1250                 1255                 1260             


Val Glu  Gly Thr Asp Gly Val  Lys Lys Arg Lys Arg  Lys Pro Tyr 
    1265                 1270                 1275             


Arg Pro  Gly Ile Gly Gly Phe  Met Val Arg Gln Arg  Ser Arg Thr 
    1280                 1285                 1290             


Gly Gln  Gly Lys Thr Lys Arg  Ser Val Ile Arg Lys  Asp Ser Ser 
    1295                 1300                 1305             


Gly Ser  Ile Ser Glu Gln Leu  Pro Cys Arg Asp Asp  Gly Trp Ser 
    1310                 1315                 1320             


Glu Gln  Leu Pro Asp Thr Leu  Val Asp Glu Ser Val  Ser Val Thr 
    1325                 1330                 1335             


Glu Ser  Thr Glu Lys Ile Lys  Lys Arg Tyr Arg Lys  Arg Lys Asn 
    1340                 1345                 1350             


Lys Leu  Glu Glu Thr Phe Pro  Ala Tyr Leu Gln Glu  Ala Phe Phe 
    1355                 1360                 1365             


Gly Lys  Asp Leu Leu Asp Thr  Ser Arg Gln Ser Lys  Ile Ser Leu 
    1370                 1375                 1380             


Asp Asn  Leu Ser Glu Asp Gly  Ala Gln Leu Leu Tyr  Lys Thr Asn 
    1385                 1390                 1395             


Met Asn  Thr Gly Phe Leu Asp  Pro Ser Leu Asp Pro  Leu Leu Ser 
    1400                 1405                 1410             


Ser Ser  Ser Ala Pro Thr Lys  Ser Gly Thr His Gly  Pro Ala Asp 
    1415                 1420                 1425             


Asp Pro  Leu Ala Asp Ile Ser  Glu Val Leu Asn Thr  Asp Asp Asp 
    1430                 1435                 1440             


Ile Leu  Gly Ile Ile Ser Asp  Asp Leu Ala Lys Ser  Val Asp His 
    1445                 1450                 1455             


Ser Asp  Ile Gly Pro Val Thr  Asp Asp Pro Ser Ser  Leu Pro Gln 
    1460                 1465                 1470             


Pro Asn  Val Asn Gln Ser Ser  Arg Pro Leu Ser Glu  Glu Gln Leu 
    1475                 1480                 1485             


Asp Gly  Ile Leu Ser Pro Glu  Leu Asp Lys Met Val  Thr Asp Gly 
    1490                 1495                 1500             


Ala Ile  Leu Gly Lys Leu Tyr  Lys Ile Pro Glu Leu  Gly Gly Lys 
    1505                 1510                 1515             


Asp Val  Glu Asp Leu Phe Thr  Ala Val Leu Ser Pro  Ala Asn Thr 
    1520                 1525                 1530             


Gln Pro  Thr Pro Leu Pro Gln  Pro Pro Pro Pro Thr  Gln Leu Leu 
    1535                 1540                 1545             


Pro Ile  His Asn Gln Asp Ala  Phe Ser Arg Met Pro  Leu Met Asn 
    1550                 1555                 1560             


Gly Leu  Ile Gly Ser Ser Pro  His Leu Pro His Asn  Ser Leu Pro 
    1565                 1570                 1575             


Pro Gly  Ser Gly Leu Gly Thr  Phe Ser Ala Ile Ala  Gln Ser Ser 
    1580                 1585                 1590             


Tyr Pro  Asp Ala Arg Asp Lys  Asn Ser Ala Phe Asn  Pro Met Ala 
    1595                 1600                 1605             


Ser Asp  Pro Asn Asn Ser Trp  Thr Ser Ser Ala Pro  Thr Val Glu 
    1610                 1615                 1620             


Gly Glu  Asn Asp Thr Met Ser  Asn Ala Gln Arg Ser  Thr Leu Lys 
    1625                 1630                 1635             


Trp Glu  Lys Glu Glu Ala Leu  Gly Glu Met Ala Thr  Val Ala Pro 
    1640                 1645                 1650             


Val Leu  Tyr Thr Asn Ile Asn  Phe Pro Asn Leu Lys  Glu Glu Phe 
    1655                 1660                 1665             


Pro Asp  Trp Thr Thr Arg Val  Lys Gln Ile Ala Lys  Leu Trp Arg 
    1670                 1675                 1680             


Lys Ala  Ser Ser Gln Glu Arg  Ala Pro Tyr Val Gln  Lys Ala Arg 
    1685                 1690                 1695             


Asp Asn  Arg Ala Ala Leu Arg  Ile Asn Lys Val Gln  Met Ser Asn 
    1700                 1705                 1710             


Asp Ser  Met Lys Arg Gln Gln  Gln Gln Asp Ser Ile  Asp Pro Ser 
    1715                 1720                 1725             


Ser Arg  Ile Asp Ser Glu Leu  Phe Lys Asp Pro Leu  Lys Gln Arg 
    1730                 1735                 1740             


Glu Ser  Glu His Glu Gln Glu  Trp Lys Phe Arg Gln  Gln Met Arg 
    1745                 1750                 1755             


Gln Lys  Ser Lys Gln Gln Ala  Lys Ile Glu Ala Thr  Gln Lys Leu 
    1760                 1765                 1770             


Glu Gln  Val Lys Asn Glu Gln  Gln Gln Gln Gln Gln  Gln Gln Phe 
    1775                 1780                 1785             


Gly Ser  Gln His Leu Leu Val  Gln Ser Gly Ser Asp  Thr Pro Ser 
    1790                 1795                 1800             


Ser Gly  Ile Gln Ser Pro Leu  Thr Pro Gln Pro Gly  Asn Gly Asn 
    1805                 1810                 1815             


Met Ser  Pro Ala Gln Ser Phe  His Lys Glu Leu Phe  Thr Lys Gln 
    1820                 1825                 1830             


Pro Pro  Ser Thr Pro Thr Ser  Thr Ser Ser Asp Asp  Val Phe Val 
    1835                 1840                 1845             


Lys Pro  Gln Ala Pro Pro Pro  Pro Pro Ala Pro Ser  Arg Ile Pro 
    1850                 1855                 1860             


Ile Gln  Asp Ser Leu Ser Gln  Ala Gln Thr Ser Gln  Pro Pro Ser 
    1865                 1870                 1875             


Pro Gln  Val Phe Ser Pro Gly  Ser Ser Asn Ser Arg  Pro Pro Ser 
    1880                 1885                 1890             


Pro Met  Asp Pro Tyr Ala Lys  Met Val Gly Thr Pro  Arg Pro Pro 
    1895                 1900                 1905             


Pro Val  Gly His Ser Phe Ser  Arg Arg Asn Ser Ala  Ala Pro Val 
    1910                 1915                 1920             


Glu Asn  Cys Thr Pro Leu Ser  Ser Val Ser Arg Pro  Leu Gln Met 
    1925                 1930                 1935             


Asn Glu  Thr Thr Ala Asn Arg  Pro Ser Pro Val Arg  Asp Leu Cys 
    1940                 1945                 1950             


Ser Ser  Ser Thr Thr Asn Asn  Asp Pro Tyr Ala Lys  Pro Pro Asp 
    1955                 1960                 1965             


Thr Pro  Arg Pro Val Met Thr  Asp Gln Phe Pro Lys  Ser Leu Gly 
    1970                 1975                 1980             


Leu Ser  Arg Ser Pro Val Val  Ser Glu Gln Thr Ala  Lys Gly Pro 
    1985                 1990                 1995             


Ile Ala  Ala Gly Thr Ser Asp  His Phe Thr Lys Pro  Ser Pro Arg 
    2000                 2005                 2010             


Ala Asp  Val Phe Gln Arg Gln  Arg Ile Pro Asp Ser  Tyr Ala Arg 
    2015                 2020                 2025             


Pro Leu  Leu Thr Pro Ala Pro  Leu Asp Ser Gly Pro  Gly Pro Phe 
    2030                 2035                 2040             


Lys Thr  Pro Met Gln Pro Pro  Pro Ser Ser Gln Asp  Pro Tyr Gly 
    2045                 2050                 2055             


Ser Val  Ser Gln Ala Ser Arg  Arg Leu Ser Val Asp  Pro Tyr Glu 
    2060                 2065                 2070             


Arg Pro  Ala Leu Thr Pro Arg  Pro Ile Asp Asn Phe  Ser His Asn 
    2075                 2080                 2085             


Gln Ser  Asn Asp Pro Tyr Ser  Gln Pro Pro Leu Thr  Pro His Pro 
    2090                 2095                 2100             


Ala Val  Asn Glu Ser Phe Ala  His Pro Ser Arg Ala  Phe Ser Gln 
    2105                 2110                 2115             


Pro Gly  Thr Ile Ser Arg Pro  Thr Ser Gln Asp Pro  Tyr Ser Gln 
    2120                 2125                 2130             


Pro Pro  Gly Thr Pro Arg Pro  Val Val Asp Ser Tyr  Ser Gln Ser 
    2135                 2140                 2145             


Ser Gly  Thr Ala Arg Ser Asn  Thr Asp Pro Tyr Ser  Gln Pro Pro 
    2150                 2155                 2160             


Gly Thr  Pro Arg Pro Thr Thr  Val Asp Pro Tyr Ser  Gln Gln Pro 
    2165                 2170                 2175             


Gln Thr  Pro Arg Pro Ser Thr  Gln Thr Asp Leu Phe  Val Thr Pro 
    2180                 2185                 2190             


Val Thr  Asn Gln Arg His Ser  Asp Pro Tyr Ala His  Pro Pro Gly 
    2195                 2200                 2205             


Thr Pro  Arg Pro Gly Ile Ser  Val Pro Tyr Ser Gln  Pro Pro Ala 
    2210                 2215                 2220             


Thr Pro  Arg Pro Arg Ile Ser  Glu Gly Phe Thr Arg  Ser Ser Met 
    2225                 2230                 2235             


Thr Arg  Pro Val Leu Met Pro  Asn Gln Asp Pro Phe  Leu Gln Ala 
    2240                 2245                 2250             


Ala Gln  Asn Arg Gly Pro Ala  Leu Pro Gly Pro Leu  Val Arg Pro 
    2255                 2260                 2265             


Pro Asp  Thr Cys Ser Gln Thr  Pro Arg Pro Pro Gly  Pro Gly Leu 
    2270                 2275                 2280             


Ser Asp  Thr Phe Ser Arg Val  Ser Pro Ser Ala Ala  Arg Asp Pro 
    2285                 2290                 2295             


Tyr Asp  Gln Ser Pro Met Thr  Pro Arg Ser Gln Ser  Asp Ser Phe 
    2300                 2305                 2310             


Gly Thr  Ser Gln Thr Ala His  Asp Val Ala Asp Gln  Pro Arg Pro 
    2315                 2320                 2325             


Gly Ser  Glu Gly Ser Phe Cys  Ala Ser Ser Asn Ser  Pro Met His 
    2330                 2335                 2340             


Ser Gln  Gly Gln Gln Phe Ser  Gly Val Ser Gln Leu  Pro Gly Pro 
    2345                 2350                 2355             


Val Pro  Thr Ser Gly Val Thr  Asp Thr Gln Asn Thr  Val Asn Met 
    2360                 2365                 2370             


Ala Gln  Ala Asp Thr Glu Lys  Leu Arg Gln Arg Gln  Lys Leu Arg 
    2375                 2380                 2385             


Glu Ile  Ile Leu Gln Gln Gln  Gln Gln Lys Lys Ile  Ala Gly Arg 
    2390                 2395                 2400             


Gln Glu  Lys Gly Ser Gln Asp  Ser Pro Ala Val Pro  His Pro Gly 
    2405                 2410                 2415             


Pro Leu  Gln His Trp Gln Pro  Glu Asn Val Asn Gln  Ala Phe Thr 
    2420                 2425                 2430             


Arg Pro  Pro Pro Pro Tyr Pro  Gly Asn Ile Arg Ser  Pro Val Ala 
    2435                 2440                 2445             


Pro Pro  Leu Gly Pro Arg Tyr  Ala Val Phe Pro Lys  Asp Gln Arg 
    2450                 2455                 2460             


Gly Pro  Tyr Pro Pro Asp Val  Ala Ser Met Gly Met  Arg Pro His 
    2465                 2470                 2475             


Gly Phe  Arg Phe Gly Phe Pro  Gly Gly Ser His Gly  Thr Met Pro 
    2480                 2485                 2490             


Ser Gln  Glu Arg Phe Leu Val  Pro Pro Gln Gln Ile  Gln Gly Ser 
    2495                 2500                 2505             


Gly Val  Ser Pro Gln Leu Arg  Arg Ser Val Ser Val  Asp Met Pro 
    2510                 2515                 2520             


Arg Pro  Leu Asn Asn Ser Gln  Met Asn Asn Pro Val  Gly Leu Pro 
    2525                 2530                 2535             


Gln His  Phe Ser Pro Gln Ser  Leu Pro Val Gln Gln  His Asn Ile 
    2540                 2545                 2550             


Leu Gly  Gln Ala Tyr Ile Glu  Leu Arg His Arg Ala  Pro Asp Gly 
    2555                 2560                 2565             


Arg Gln  Arg Leu Pro Phe Ser  Ala Pro Pro Gly Ser  Val Val Glu 
    2570                 2575                 2580             


Ala Ser  Ser Asn Leu Arg His  Gly Asn Phe Ile Pro  Arg Pro Asp 
    2585                 2590                 2595             


Phe Pro  Gly Pro Arg His Thr  Asp Pro Met Arg Arg  Pro Pro Gln 
    2600                 2605                 2610             


Gly Leu  Pro Asn Gln Leu Pro  Val His Pro Asp Leu  Glu Gln Val 
    2615                 2620                 2625             


Pro Pro  Ser Gln Gln Glu Gln  Gly His Ser Val His  Ser Ser Ser 
    2630                 2635                 2640             


Met Val  Met Arg Thr Leu Asn  His Pro Leu Gly Gly  Glu Phe Ser 
    2645                 2650                 2655             


Glu Ala  Pro Leu Ser Thr Ser  Val Pro Ser Glu Thr  Thr Ser Asp 
    2660                 2665                 2670             


Asn Leu  Gln Ile Thr Thr Gln  Pro Ser Asp Gly Leu  Glu Glu Lys 
    2675                 2680                 2685             


Leu Asp  Ser Asp Asp Pro Ser  Val Lys Glu Leu Asp  Val Lys Asp 
    2690                 2695                 2700             


Leu Glu  Gly Val Glu Val Lys  Asp Leu Asp Asp Glu  Asp Leu Glu 
    2705                 2710                 2715             


Asn Leu  Asn Leu Asp Thr Glu  Asp Gly Lys Val Val  Glu Leu Asp 
    2720                 2725                 2730             


Thr Leu  Asp Asn Leu Glu Thr  Asn Asp Pro Asn Leu  Asp Asp Leu 
    2735                 2740                 2745             


Leu Arg  Ser Gly Glu Phe Asp  Ile Ile Ala Tyr Thr  Asp Pro Glu 
    2750                 2755                 2760             


Leu Asp  Met Gly Asp Lys Lys  Ser Met Phe Asn Glu  Glu Leu Asp 
    2765                 2770                 2775             


Leu Pro  Ile Asp Asp Lys Leu  Asp Asn Gln Cys Val  Ser Val Glu 
    2780                 2785                 2790             


Pro Lys  Lys Lys Glu Gln Glu  Asn Lys Thr Leu Val  Leu Ser Asp 
    2795                 2800                 2805             


Lys His  Ser Pro Gln Lys Lys  Ser Thr Val Thr Asn  Glu Val Lys 
    2810                 2815                 2820             


Thr Glu  Val Leu Ser Pro Asn  Ser Lys Val Glu Ser  Lys Cys Glu 
    2825                 2830                 2835             


Thr Glu  Lys Asn Asp Glu Asn  Lys Asp Asn Val Asp  Thr Pro Cys 
    2840                 2845                 2850             


Ser Gln  Ala Ser Ala His Ser  Asp Leu Asn Asp Gly  Glu Lys Thr 
    2855                 2860                 2865             


Ser Leu  His Pro Cys Asp Pro  Asp Leu Phe Glu Lys  Arg Thr Asn 
    2870                 2875                 2880             


Arg Glu  Thr Ala Gly Pro Ser  Ala Asn Val Ile Gln  Ala Ser Thr 
    2885                 2890                 2895             


Gln Leu  Pro Ala Gln Asp Val  Ile Asn Ser Cys Gly  Ile Thr Gly 
    2900                 2905                 2910             


Ser Thr  Pro Val Leu Ser Ser  Leu Leu Ala Asn Glu  Lys Ser Asp 
    2915                 2920                 2925             


Asn Ser  Asp Ile Arg Pro Ser  Gly Ser Pro Pro Pro  Pro Thr Leu 
    2930                 2935                 2940             


Pro Ala  Ser Pro Ser Asn His  Val Ser Ser Leu Pro  Pro Phe Ile 
    2945                 2950                 2955             


Ala Pro  Pro Gly Arg Val Leu  Asp Asn Ala Met Asn  Ser Asn Val 
    2960                 2965                 2970             


Thr Val  Val Ser Arg Val Asn  His Val Phe Ser Gln  Gly Val Gln 
    2975                 2980                 2985             


Val Asn  Pro Gly Leu Ile Pro  Gly Gln Ser Thr Val  Asn His Ser 
    2990                 2995                 3000             


Leu Gly  Thr Gly Lys Pro Ala  Thr Gln Thr Gly Pro  Gln Thr Ser 
    3005                 3010                 3015             


Gln Ser  Gly Thr Ser Ser Met  Ser Gly Pro Gln Gln  Leu Met Ile 
    3020                 3025                 3030             


Pro Gln  Thr Leu Ala Gln Gln  Asn Arg Glu Arg Pro  Leu Leu Leu 
    3035                 3040                 3045             


Glu Glu  Gln Pro Leu Leu Leu  Gln Asp Leu Leu Asp  Gln Glu Arg 
    3050                 3055                 3060             


Gln Glu  Gln Gln Gln Gln Arg  Gln Met Gln Ala Met  Ile Arg Gln 
    3065                 3070                 3075             


Arg Ser  Glu Pro Phe Phe Pro  Asn Ile Asp Phe Asp  Ala Ile Thr 
    3080                 3085                 3090             


Asp Pro  Ile Met Lys Ala Lys  Met Val Ala Leu Lys  Gly Ile Asn 
    3095                 3100                 3105             


Lys Val  Met Ala Gln Asn Asn  Leu Gly Met Pro Pro  Met Val Met 
    3110                 3115                 3120             


Ser Arg  Phe Pro Phe Met Gly  Gln Val Val Thr Gly  Thr Gln Asn 
    3125                 3130                 3135             


Ser Glu  Gly Gln Asn Leu Gly  Pro Gln Ala Ile Pro  Gln Asp Gly 
    3140                 3145                 3150             


Ser Ile  Thr His Gln Ile Ser  Arg Pro Asn Pro Pro  Asn Phe Gly 
    3155                 3160                 3165             


Pro Gly  Phe Val Asn Asp Ser  Gln Arg Lys Gln Tyr  Glu Glu Trp 
    3170                 3175                 3180             


Leu Gln  Glu Thr Gln Gln Leu  Leu Gln Met Gln Gln  Lys Tyr Leu 
    3185                 3190                 3195             


Glu Glu  Gln Ile Gly Ala His  Arg Lys Ser Lys Lys  Ala Leu Ser 
    3200                 3205                 3210             


Ala Lys  Gln Arg Thr Ala Lys  Lys Ala Gly Arg Glu  Phe Pro Glu 
    3215                 3220                 3225             


Glu Asp  Ala Glu Gln Leu Lys  His Val Thr Glu Gln  Gln Ser Met 
    3230                 3235                 3240             


Val Gln  Lys Gln Leu Glu Gln  Ile Arg Lys Gln Gln  Lys Glu His 
    3245                 3250                 3255             


Ala Glu  Leu Ile Glu Asp Tyr  Arg Ile Lys Gln Gln  Gln Gln Cys 
    3260                 3265                 3270             


Ala Met  Ala Pro Pro Thr Met  Met Pro Ser Val Gln  Pro Gln Pro 
    3275                 3280                 3285             


Pro Leu  Ile Pro Gly Ala Thr  Pro Pro Thr Met Ser  Gln Pro Thr 
    3290                 3295                 3300             


Phe Pro  Met Val Pro Gln Gln  Leu Gln His Gln Gln  His Thr Thr 
    3305                 3310                 3315             


Val Ile  Ser Gly His Thr Ser  Pro Val Arg Met Pro  Ser Leu Pro 
    3320                 3325                 3330             


Gly Trp  Gln Pro Asn Ser Ala  Pro Ala His Leu Pro  Leu Asn Pro 
    3335                 3340                 3345             


Pro Arg  Ile Gln Pro Pro Ile  Ala Gln Leu Pro Ile  Lys Thr Cys 
    3350                 3355                 3360             


Thr Pro  Ala Pro Gly Thr Val  Ser Asn Ala Asn Pro  Gln Ser Gly 
    3365                 3370                 3375             


Pro Pro  Pro Arg Val Glu Phe  Asp Asp Asn Asn Pro  Phe Ser Glu 
    3380                 3385                 3390             


Ser Phe  Gln Glu Arg Glu Arg  Lys Glu Arg Leu Arg  Glu Gln Gln 
    3395                 3400                 3405             


Glu Arg  Gln Arg Ile Gln Leu  Met Gln Glu Val Asp  Arg Gln Arg 
    3410                 3415                 3420             


Ala Leu  Gln Gln Arg Met Glu  Met Glu Gln His Gly  Met Val Gly 
    3425                 3430                 3435             


Ser Glu  Ile Ser Ser Ser Arg  Thr Ser Val Ser Gln  Ile Pro Phe 
    3440                 3445                 3450             


Tyr Ser  Ser Asp Leu Pro Cys  Asp Phe Met Gln Pro  Leu Gly Pro 
    3455                 3460                 3465             


Leu Gln  Gln Ser Pro Gln His  Gln Gln Gln Met Gly  Gln Val Leu 
    3470                 3475                 3480             


Gln Gln  Gln Asn Ile Gln Gln  Gly Ser Ile Asn Ser  Pro Ser Thr 
    3485                 3490                 3495             


Gln Thr  Phe Met Gln Thr Asn  Glu Arg Arg Gln Val  Gly Pro Pro 
    3500                 3505                 3510             


Ser Phe  Val Pro Asp Ser Pro  Ser Ile Pro Val Gly  Ser Pro Asn 
    3515                 3520                 3525             


Phe Ser  Ser Val Lys Gln Gly  His Gly Asn Leu Ser  Gly Thr Ser 
    3530                 3535                 3540             


Phe Gln  Gln Ser Pro Val Arg  Pro Ser Phe Thr Pro  Ala Leu Pro 
    3545                 3550                 3555             


Ala Ala  Pro Pro Val Ala Asn  Ser Ser Leu Pro Cys  Gly Gln Asp 
    3560                 3565                 3570             


Ser Thr  Ile Thr His Gly His  Ser Tyr Pro Gly Ser  Thr Gln Ser 
    3575                 3580                 3585             


Leu Ile  Gln Leu Tyr Ser Asp  Ile Ile Pro Glu Glu  Lys Gly Lys 
    3590                 3595                 3600             


Lys Lys  Arg Thr Arg Lys Lys  Lys Arg Asp Asp Asp  Ala Glu Ser 
    3605                 3610                 3615             


Thr Lys  Ala Pro Ser Thr Pro  His Ser Asp Ile Thr  Ala Pro Pro 
    3620                 3625                 3630             


Thr Pro  Gly Ile Ser Glu Thr  Thr Ser Thr Pro Ala  Val Ser Thr 
    3635                 3640                 3645             


Pro Ser  Glu Leu Pro Gln Gln  Ala Asp Gln Glu Ser  Val Glu Pro 
    3650                 3655                 3660             


Val Gly  Pro Ser Thr Pro Asn  Met Ala Ala Gly Gln  Leu Cys Thr 
    3665                 3670                 3675             


Glu Leu  Glu Asn Lys Leu Pro  Asn Ser Asp Phe Ser  Gln Ala Thr 
    3680                 3685                 3690             


Pro Asn  Gln Gln Thr Tyr Ala  Asn Ser Glu Val Asp  Lys Leu Ser 
    3695                 3700                 3705             


Met Glu  Thr Pro Ala Lys Thr  Glu Glu Ile Lys Leu  Glu Lys Ala 
    3710                 3715                 3720             


Glu Thr  Glu Ser Cys Pro Gly  Gln Glu Glu Pro Lys  Leu Glu Glu 
    3725                 3730                 3735             


Gln Asn  Gly Ser Lys Val Glu  Gly Asn Ala Val Ala  Cys Pro Val 
    3740                 3745                 3750             


Ser Ser  Ala Gln Ser Pro Pro  His Ser Ala Gly Ala  Pro Ala Ala 
    3755                 3760                 3765             


Lys Gly  Asp Ser Gly Asn Glu  Leu Leu Lys His Leu  Leu Lys Asn 
    3770                 3775                 3780             


Lys Lys  Ser Ser Ser Leu Leu  Asn Gln Lys Pro Glu  Gly Ser Ile 
    3785                 3790                 3795             


Cys Ser  Glu Asp Asp Cys Thr  Lys Asp Asn Lys Leu  Val Glu Lys 
    3800                 3805                 3810             


Gln Asn  Pro Ala Glu Gly Leu  Gln Thr Leu Gly Ala  Gln Met Gln 
    3815                 3820                 3825             


Gly Gly  Phe Gly Cys Gly Asn  Gln Leu Pro Lys Thr  Asp Gly Gly 
    3830                 3835                 3840             


Ser Glu  Thr Lys Lys Gln Arg  Ser Lys Arg Thr Gln  Arg Thr Gly 
    3845                 3850                 3855             


Glu Lys  Ala Ala Pro Arg Ser  Lys Lys Arg Lys Lys  Asp Glu Glu 
    3860                 3865                 3870             


Glu Lys  Gln Ala Met Tyr Ser  Ser Thr Asp Thr Phe  Thr His Leu 
    3875                 3880                 3885             


Lys Gln  Gln Asn Asn Leu Ser  Asn Pro Pro Thr Pro  Pro Ala Ser 
    3890                 3895                 3900             


Leu Pro  Pro Thr Pro Pro Pro  Met Ala Cys Gln Lys  Met Ala Asn 
    3905                 3910                 3915             


Gly Phe  Ala Thr Thr Glu Glu  Leu Ala Gly Lys Ala  Gly Val Leu 
    3920                 3925                 3930             


Val Ser  His Glu Val Thr Lys  Thr Leu Gly Pro Lys  Pro Phe Gln 
    3935                 3940                 3945             


Leu Pro  Phe Arg Pro Gln Asp  Asp Leu Leu Ala Arg  Ala Leu Ala 
    3950                 3955                 3960             


Gln Gly  Pro Lys Thr Val Asp  Val Pro Ala Ser Leu  Pro Thr Pro 
    3965                 3970                 3975             


Pro His  Asn Asn Gln Glu Glu  Leu Arg Ile Gln Asp  His Cys Gly 
    3980                 3985                 3990             


Asp Arg  Asp Thr Pro Asp Ser  Phe Val Pro Ser Ser  Ser Pro Glu 
    3995                 4000                 4005             


Ser Val  Val Gly Val Glu Val  Ser Arg Tyr Pro Asp  Leu Ser Leu 
    4010                 4015                 4020             


Val Lys  Glu Glu Pro Pro Glu  Pro Val Pro Ser Pro  Ile Ile Pro 
    4025                 4030                 4035             


Ile Leu  Pro Ser Thr Ala Gly  Lys Ser Ser Glu Ser  Arg Arg Asn 
    4040                 4045                 4050             


Asp Ile  Lys Thr Glu Pro Gly  Thr Leu Tyr Phe Ala  Ser Pro Phe 
    4055                 4060                 4065             


Gly Pro  Ser Pro Asn Gly Pro  Arg Ser Gly Leu Ile  Ser Val Ala 
    4070                 4075                 4080             


Ile Thr  Leu His Pro Thr Ala  Ala Glu Asn Ile Ser  Ser Val Val 
    4085                 4090                 4095             


Ala Ala  Phe Ser Asp Leu Leu  His Val Arg Ile Pro  Asn Ser Tyr 
    4100                 4105                 4110             


Glu Val  Ser Ser Ala Pro Asp  Val Pro Ser Met Gly  Leu Val Ser 
    4115                 4120                 4125             


Ser His  Arg Ile Asn Pro Gly  Leu Glu Tyr Arg Gln  His Leu Leu 
    4130                 4135                 4140             


Leu Arg  Gly Pro Pro Pro Gly  Ser Ala Asn Pro Pro  Arg Leu Val 
    4145                 4150                 4155             


Ser Ser  Tyr Arg Leu Lys Gln  Pro Asn Val Pro Phe  Pro Pro Thr 
    4160                 4165                 4170             


Ser Asn  Gly Leu Ser Gly Tyr  Lys Asp Ser Ser His  Gly Ile Ala 
    4175                 4180                 4185             


Glu Ser  Ala Ala Leu Arg Pro  Gln Trp Cys Cys His  Cys Lys Val 
    4190                 4195                 4200             


Val Ile  Leu Gly Ser Gly Val  Arg Lys Ser Phe Lys  Asp Leu Thr 
    4205                 4210                 4215             


Leu Leu  Asn Lys Asp Ser Arg  Glu Ser Thr Lys Arg  Val Glu Lys 
    4220                 4225                 4230             


Asp Ile  Val Phe Cys Ser Asn  Asn Cys Phe Ile Leu  Tyr Ser Ser 
    4235                 4240                 4245             


Thr Ala  Gln Ala Lys Asn Ser  Glu Asn Lys Glu Ser  Ile Pro Ser 
    4250                 4255                 4260             


Leu Pro  Gln Ser Pro Met Arg  Glu Thr Pro Ser Lys  Ala Phe His 
    4265                 4270                 4275             


Gln Tyr  Ser Asn Asn Ile Ser  Thr Leu Asp Val His  Cys Leu Pro 
    4280                 4285                 4290             


Gln Leu  Pro Glu Lys Ala Ser  Pro Pro Ala Ser Pro  Pro Ile Ala 
    4295                 4300                 4305             


Phe Pro  Pro Ala Phe Glu Ala  Ala Gln Val Glu Ala  Lys Pro Asp 
    4310                 4315                 4320             


Glu Leu  Lys Val Thr Val Lys  Leu Lys Pro Arg Leu  Arg Ala Val 
    4325                 4330                 4335             


His Gly  Gly Phe Glu Asp Cys  Arg Pro Leu Asn Lys  Lys Trp Arg 
    4340                 4345                 4350             


Gly Met  Lys Trp Lys Lys Trp  Ser Ile His Ile Val  Ile Pro Lys 
    4355                 4360                 4365             


Gly Thr  Phe Lys Pro Pro Cys  Glu Asp Glu Ile Asp  Glu Phe Leu 
    4370                 4375                 4380             


Lys Lys  Leu Gly Thr Ser Leu  Lys Pro Asp Pro Val  Pro Lys Asp 
    4385                 4390                 4395             


Tyr Arg  Lys Cys Cys Phe Cys  His Glu Glu Gly Asp  Gly Leu Thr 
    4400                 4405                 4410             


Asp Gly  Pro Ala Arg Leu Leu  Asn Leu Asp Leu Asp  Leu Trp Val 
    4415                 4420                 4425             


His Leu  Asn Cys Ala Leu Trp  Ser Thr Glu Val Tyr  Glu Thr Gln 
    4430                 4435                 4440             


Ala Gly  Ala Leu Ile Asn Val  Glu Leu Ala Leu Arg  Arg Gly Leu 
    4445                 4450                 4455             


Gln Met  Lys Cys Val Phe Cys  His Lys Thr Gly Ala  Thr Ser Gly 
    4460                 4465                 4470             


Cys His  Arg Phe Arg Cys Thr  Asn Ile Tyr His Phe  Thr Cys Ala 
    4475                 4480                 4485             


Ile Lys  Ala Gln Cys Met Phe  Phe Lys Asp Lys Thr  Met Leu Cys 
    4490                 4495                 4500             


Pro Met  His Lys Pro Lys Gly  Ile His Glu Gln Glu  Leu Ser Tyr 
    4505                 4510                 4515             


Phe Ala  Val Phe Arg Arg Val  Tyr Val Gln Arg Asp  Glu Val Arg 
    4520                 4525                 4530             


Gln Ile  Ala Ser Ile Val Gln  Arg Gly Glu Arg Asp  His Thr Phe 
    4535                 4540                 4545             


Arg Val  Gly Ser Leu Ile Phe  His Thr Ile Gly Gln  Leu Leu Pro 
    4550                 4555                 4560             


Gln Gln  Met Gln Ala Phe His  Ser Pro Lys Ala Leu  Phe Pro Val 
    4565                 4570                 4575             


Gly Tyr  Glu Ala Ser Arg Leu  Tyr Trp Ser Thr Arg  Tyr Ala Asn 
    4580                 4585                 4590             


Arg Arg  Cys Arg Tyr Leu Cys  Ser Ile Glu Glu Lys  Asp Gly Arg 
    4595                 4600                 4605             


Pro Val  Phe Val Ile Arg Ile  Val Glu Gln Gly His  Glu Asp Leu 
    4610                 4615                 4620             


Val Leu  Ser Asp Ile Ser Pro  Lys Gly Val Trp Asp  Lys Ile Leu 
    4625                 4630                 4635             


Glu Pro  Val Ala Cys Val Arg  Lys Lys Ser Glu Met  Leu Gln Leu 
    4640                 4645                 4650             


Phe Pro  Ala Tyr Leu Lys Gly  Glu Asp Leu Phe Gly  Leu Thr Val 
    4655                 4660                 4665             


Ser Ala  Val Ala Arg Ile Ala  Glu Ser Leu Pro Gly  Val Glu Ala 
    4670                 4675                 4680             


Cys Glu  Asn Tyr Thr Phe Arg  Tyr Gly Arg Asn Pro  Leu Met Glu 
    4685                 4690                 4695             


Leu Pro  Leu Ala Val Asn Pro  Thr Gly Cys Ala Arg  Ser Glu Pro 
    4700                 4705                 4710             


Lys Met  Ser Ala His Val Lys  Arg Phe Val Leu Arg  Pro His Thr 
    4715                 4720                 4725             


Leu Asn  Ser Thr Ser Thr Ser  Lys Ser Phe Gln Ser  Thr Val Thr 
    4730                 4735                 4740             


Gly Glu  Leu Asn Ala Pro Tyr  Ser Lys Gln Phe Val  His Ser Lys 
    4745                 4750                 4755             


Ser Ser  Gln Tyr Arg Lys Met  Lys Thr Glu Trp Lys  Ser Asn Val 
    4760                 4765                 4770             


Tyr Leu  Ala Arg Ser Arg Ile  Gln Gly Leu Gly Leu  Tyr Ala Ala 
    4775                 4780                 4785             


Arg Asp  Ile Glu Lys His Thr  Met Val Ile Glu Tyr  Ile Gly Thr 
    4790                 4795                 4800             


Ile Ile  Arg Asn Glu Val Ala  Asn Arg Lys Glu Lys  Leu Tyr Glu 
    4805                 4810                 4815             


Ser Gln  Asn Arg Gly Val Tyr  Met Phe Arg Met Asp  Asn Asp His 
    4820                 4825                 4830             


Val Ile  Asp Ala Thr Leu Thr  Gly Gly Pro Ala Arg  Tyr Ile Asn 
    4835                 4840                 4845             


His Ser  Cys Ala Pro Asn Cys  Val Ala Glu Val Val  Thr Phe Glu 
    4850                 4855                 4860             


Arg Gly  His Lys Ile Ile Ile  Ser Ser Ser Arg Arg  Ile Gln Lys 
    4865                 4870                 4875             


Gly Glu  Glu Leu Cys Tyr Asp  Tyr Lys Phe Asp Phe  Glu Asp Asp 
    4880                 4885                 4890             


Gln His  Lys Ile Pro Cys His  Cys Gly Ala Val Asn  Cys Arg Lys 
    4895                 4900                 4905             


Trp Met  Asn 
    4910     


<210>  5995
<211>  5537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KMT2D__Homo_sapiens__XP_005269219

<400>  5995

Met Asp Ser Gln Lys Leu Ala Gly Glu Asp Lys Asp Ser Glu Pro Ala 
1               5                   10                  15      


Ala Asp Gly Pro Ala Ala Ser Glu Asp Pro Ser Ala Thr Glu Ser Asp 
            20                  25                  30          


Leu Pro Asn Pro His Val Gly Glu Val Ser Val Leu Ser Ser Gly Ser 
        35                  40                  45              


Pro Arg Leu Gln Glu Thr Pro Gln Asp Cys Ser Gly Gly Pro Val Arg 
    50                  55                  60                  


Arg Cys Ala Leu Cys Asn Cys Gly Glu Pro Ser Leu His Gly Gln Arg 
65                  70                  75                  80  


Glu Leu Arg Arg Phe Glu Leu Pro Phe Asp Trp Pro Arg Cys Pro Val 
                85                  90                  95      


Val Ser Pro Gly Gly Ser Pro Gly Pro Asn Glu Ala Val Leu Pro Ser 
            100                 105                 110         


Glu Asp Leu Ser Gln Ile Gly Phe Pro Glu Gly Leu Thr Pro Ala His 
        115                 120                 125             


Leu Gly Glu Pro Gly Gly Ser Cys Trp Ala His His Trp Cys Ala Ala 
    130                 135                 140                 


Trp Ser Ala Gly Val Trp Gly Gln Glu Gly Pro Glu Leu Cys Gly Val 
145                 150                 155                 160 


Asp Lys Ala Ile Phe Ser Gly Ile Ser Gln Arg Cys Ser His Cys Thr 
                165                 170                 175     


Arg Leu Gly Ala Ser Ile Pro Cys Arg Ser Pro Gly Cys Pro Arg Leu 
            180                 185                 190         


Tyr His Phe Pro Cys Ala Thr Ala Ser Gly Ser Phe Leu Ser Met Lys 
        195                 200                 205             


Thr Leu Gln Leu Leu Cys Pro Glu His Ser Glu Gly Ala Ala Tyr Leu 
    210                 215                 220                 


Glu Glu Ala Arg Cys Ala Val Cys Glu Gly Pro Gly Glu Leu Cys Asp 
225                 230                 235                 240 


Leu Phe Phe Cys Thr Ser Cys Gly His His Tyr His Gly Ala Cys Leu 
                245                 250                 255     


Asp Thr Ala Leu Thr Ala Arg Lys Arg Ala Gly Trp Gln Cys Pro Glu 
            260                 265                 270         


Cys Lys Val Cys Gln Ala Cys Arg Lys Pro Gly Asn Asp Ser Lys Met 
        275                 280                 285             


Leu Val Cys Glu Thr Cys Asp Lys Gly Tyr His Thr Phe Cys Leu Lys 
    290                 295                 300                 


Pro Pro Met Glu Glu Leu Pro Ala His Ser Trp Lys Cys Lys Ala Cys 
305                 310                 315                 320 


Arg Val Cys Arg Ala Cys Gly Ala Gly Ser Ala Glu Leu Asn Pro Asn 
                325                 330                 335     


Ser Glu Trp Phe Glu Asn Tyr Ser Leu Cys His Arg Cys His Lys Ala 
            340                 345                 350         


Gln Gly Gly Gln Thr Ile Arg Ser Val Ala Glu Gln His Thr Pro Val 
        355                 360                 365             


Cys Ser Arg Phe Ser Pro Pro Glu Pro Gly Asp Thr Pro Thr Asp Glu 
    370                 375                 380                 


Pro Asp Ala Leu Tyr Val Ala Cys Gln Gly Gln Pro Lys Gly Gly His 
385                 390                 395                 400 


Val Thr Ser Met Gln Pro Lys Glu Pro Gly Pro Leu Gln Cys Glu Ala 
                405                 410                 415     


Lys Pro Leu Gly Lys Ala Gly Val Gln Leu Glu Pro Gln Leu Glu Ala 
            420                 425                 430         


Pro Leu Asn Glu Glu Met Pro Leu Leu Pro Pro Pro Glu Glu Ser Pro 
        435                 440                 445             


Leu Ser Pro Pro Pro Glu Glu Ser Pro Thr Ser Pro Pro Pro Glu Ala 
    450                 455                 460                 


Ser Arg Leu Ser Pro Pro Pro Glu Glu Leu Pro Ala Ser Pro Leu Pro 
465                 470                 475                 480 


Glu Ala Leu His Leu Ser Arg Pro Leu Glu Glu Ser Pro Leu Ser Pro 
                485                 490                 495     


Pro Pro Glu Glu Ser Pro Leu Ser Pro Pro Pro Glu Ser Ser Pro Phe 
            500                 505                 510         


Ser Pro Leu Glu Glu Ser Pro Leu Ser Pro Pro Glu Glu Ser Pro Pro 
        515                 520                 525             


Ser Pro Ala Leu Glu Thr Pro Leu Ser Pro Pro Pro Glu Ala Ser Pro 
    530                 535                 540                 


Leu Ser Pro Pro Phe Glu Glu Ser Pro Leu Ser Pro Pro Pro Glu Glu 
545                 550                 555                 560 


Leu Pro Thr Ser Pro Pro Pro Glu Ala Ser Arg Leu Ser Pro Pro Pro 
                565                 570                 575     


Glu Glu Ser Pro Met Ser Pro Pro Pro Glu Glu Ser Pro Met Ser Pro 
            580                 585                 590         


Pro Pro Glu Ala Ser Arg Leu Phe Pro Pro Phe Glu Glu Ser Pro Leu 
        595                 600                 605             


Ser Pro Pro Pro Glu Glu Ser Pro Leu Ser Pro Pro Pro Glu Ala Ser 
    610                 615                 620                 


Arg Leu Ser Pro Pro Pro Glu Asp Ser Pro Met Ser Pro Pro Pro Glu 
625                 630                 635                 640 


Glu Ser Pro Met Ser Pro Pro Pro Glu Val Ser Arg Leu Ser Pro Leu 
                645                 650                 655     


Pro Val Val Ser Arg Leu Ser Pro Pro Pro Glu Glu Ser Pro Leu Ser 
            660                 665                 670         


Pro Pro Pro Glu Glu Ser Pro Thr Ser Pro Pro Pro Glu Ala Ser Arg 
        675                 680                 685             


Leu Ser Pro Pro Pro Glu Asp Ser Pro Thr Ser Pro Pro Pro Glu Asp 
    690                 695                 700                 


Ser Pro Ala Ser Pro Pro Pro Glu Asp Ser Leu Met Ser Leu Pro Leu 
705                 710                 715                 720 


Glu Glu Ser Pro Leu Leu Pro Leu Pro Glu Glu Pro Gln Leu Cys Pro 
                725                 730                 735     


Arg Ser Glu Gly Pro His Leu Ser Pro Arg Pro Glu Glu Pro His Leu 
            740                 745                 750         


Ser Pro Arg Pro Glu Glu Pro His Leu Ser Pro Gln Ala Glu Glu Pro 
        755                 760                 765             


His Leu Ser Pro Gln Pro Glu Glu Pro Cys Leu Cys Ala Val Pro Glu 
    770                 775                 780                 


Glu Pro His Leu Ser Pro Gln Ala Glu Gly Pro His Leu Ser Pro Gln 
785                 790                 795                 800 


Pro Glu Glu Leu His Leu Ser Pro Gln Thr Glu Glu Pro His Leu Ser 
                805                 810                 815     


Pro Val Pro Glu Glu Pro Cys Leu Ser Pro Gln Pro Glu Glu Ser His 
            820                 825                 830         


Leu Ser Pro Gln Ser Glu Glu Pro Cys Leu Ser Pro Arg Pro Glu Glu 
        835                 840                 845             


Ser His Leu Ser Pro Glu Leu Glu Lys Pro Pro Leu Ser Pro Arg Pro 
    850                 855                 860                 


Glu Lys Pro Pro Glu Glu Pro Gly Gln Cys Pro Ala Pro Glu Glu Leu 
865                 870                 875                 880 


Pro Leu Phe Pro Pro Pro Gly Glu Pro Ser Leu Ser Pro Leu Leu Gly 
                885                 890                 895     


Glu Pro Ala Leu Ser Glu Pro Gly Glu Pro Pro Leu Ser Pro Leu Pro 
            900                 905                 910         


Glu Glu Leu Pro Leu Ser Pro Ser Gly Glu Pro Ser Leu Ser Pro Gln 
        915                 920                 925             


Leu Met Pro Pro Asp Pro Leu Pro Pro Pro Leu Ser Pro Ile Ile Thr 
    930                 935                 940                 


Ala Ala Ala Pro Pro Ala Leu Ser Pro Leu Gly Glu Leu Glu Tyr Pro 
945                 950                 955                 960 


Phe Gly Ala Lys Gly Asp Ser Asp Pro Glu Ser Pro Leu Ala Ala Pro 
                965                 970                 975     


Ile Leu Glu Thr Pro Ile Ser Pro Pro Pro Glu Ala Asn Cys Thr Asp 
            980                 985                 990         


Pro Glu Pro Val Pro Pro Met Ile  Leu Pro Pro Ser Pro  Gly Ser Pro 
        995                 1000                 1005             


Val Gly  Pro Ala Ser Pro Ile  Leu Met Glu Pro Leu  Pro Pro Gln 
    1010                 1015                 1020             


Cys Ser  Pro Leu Leu Gln His  Ser Leu Val Pro Gln  Asn Ser Pro 
    1025                 1030                 1035             


Pro Ser  Gln Cys Ser Pro Pro  Ala Leu Pro Leu Ser  Val Pro Ser 
    1040                 1045                 1050             


Pro Leu  Ser Pro Ile Gly Lys  Val Val Gly Val Ser  Asp Glu Ala 
    1055                 1060                 1065             


Glu Leu  His Glu Met Glu Thr  Glu Lys Val Ser Glu  Pro Glu Cys 
    1070                 1075                 1080             


Pro Ala  Leu Glu Pro Ser Ala  Thr Ser Pro Leu Pro  Ser Pro Met 
    1085                 1090                 1095             


Gly Asp  Leu Ser Cys Pro Ala  Pro Ser Pro Ala Pro  Ala Leu Asp 
    1100                 1105                 1110             


Asp Phe  Ser Gly Leu Gly Glu  Asp Thr Ala Pro Leu  Asp Gly Ile 
    1115                 1120                 1125             


Asp Ala  Pro Gly Ser Gln Pro  Glu Pro Gly Gln Thr  Pro Gly Ser 
    1130                 1135                 1140             


Leu Ala  Ser Glu Leu Lys Gly  Ser Pro Val Leu Leu  Asp Pro Glu 
    1145                 1150                 1155             


Glu Leu  Ala Pro Val Thr Pro  Met Glu Val Tyr Pro  Glu Cys Lys 
    1160                 1165                 1170             


Gln Thr  Ala Gly Gln Gly Ser  Pro Cys Glu Glu Gln  Glu Glu Pro 
    1175                 1180                 1185             


Arg Ala  Pro Val Ala Pro Thr  Pro Pro Thr Leu Ile  Lys Ser Asp 
    1190                 1195                 1200             


Ile Val  Asn Glu Ile Ser Asn  Leu Ser Gln Gly Asp  Ala Ser Ala 
    1205                 1210                 1215             


Ser Phe  Pro Gly Ser Glu Pro  Leu Leu Gly Ser Pro  Asp Pro Glu 
    1220                 1225                 1230             


Gly Gly  Gly Ser Leu Ser Met  Glu Leu Gly Val Ser  Thr Asp Val 
    1235                 1240                 1245             


Ser Pro  Ala Arg Asp Glu Gly  Ser Leu Arg Leu Cys  Thr Asp Ser 
    1250                 1255                 1260             


Leu Pro  Glu Thr Asp Asp Ser  Leu Leu Cys Asp Ala  Gly Thr Ala 
    1265                 1270                 1275             


Ile Ser  Gly Gly Lys Ala Glu  Gly Glu Lys Gly Arg  Arg Arg Ser 
    1280                 1285                 1290             


Ser Pro  Ala Arg Ser Arg Ile  Lys Gln Gly Arg Ser  Ser Ser Phe 
    1295                 1300                 1305             


Pro Gly  Arg Arg Arg Pro Arg  Gly Gly Ala His Gly  Gly Arg Gly 
    1310                 1315                 1320             


Arg Gly  Arg Ala Arg Leu Lys  Ser Thr Ala Ser Ser  Ile Glu Thr 
    1325                 1330                 1335             


Leu Val  Val Ala Asp Ile Asp  Ser Ser Pro Ser Lys  Glu Glu Glu 
    1340                 1345                 1350             


Glu Glu  Asp Asp Asp Thr Met  Gln Asn Thr Val Val  Leu Phe Ser 
    1355                 1360                 1365             


Asn Thr  Asp Lys Phe Val Leu  Met Gln Asp Met Cys  Val Val Cys 
    1370                 1375                 1380             


Gly Ser  Phe Gly Arg Gly Ala  Glu Gly His Leu Leu  Ala Cys Ser 
    1385                 1390                 1395             


Gln Cys  Ser Gln Cys Tyr His  Pro Tyr Cys Val Asn  Ser Lys Ile 
    1400                 1405                 1410             


Thr Lys  Val Met Leu Leu Lys  Gly Trp Arg Cys Val  Glu Cys Ile 
    1415                 1420                 1425             


Val Cys  Glu Val Cys Gly Gln  Ala Ser Asp Pro Ser  Arg Leu Leu 
    1430                 1435                 1440             


Leu Cys  Asp Asp Cys Asp Ile  Ser Tyr His Thr Tyr  Cys Leu Asp 
    1445                 1450                 1455             


Pro Pro  Leu Leu Thr Val Pro  Lys Gly Gly Trp Lys  Cys Lys Trp 
    1460                 1465                 1470             


Cys Val  Ser Cys Met Gln Cys  Gly Ala Ala Ser Pro  Gly Phe His 
    1475                 1480                 1485             


Cys Glu  Trp Gln Asn Ser Tyr  Thr His Cys Gly Pro  Cys Ala Ser 
    1490                 1495                 1500             


Leu Val  Thr Cys Pro Ile Cys  His Ala Pro Tyr Val  Glu Glu Asp 
    1505                 1510                 1515             


Leu Leu  Ile Gln Cys Arg His  Cys Glu Arg Trp Met  His Ala Gly 
    1520                 1525                 1530             


Cys Glu  Ser Leu Phe Thr Glu  Asp Asp Val Glu Gln  Ala Ala Asp 
    1535                 1540                 1545             


Glu Gly  Phe Asp Cys Val Ser  Cys Gln Pro Tyr Val  Val Lys Pro 
    1550                 1555                 1560             


Val Ala  Pro Val Ala Pro Pro  Glu Leu Val Pro Met  Lys Val Lys 
    1565                 1570                 1575             


Glu Pro  Glu Pro Gln Tyr Phe  Arg Phe Glu Gly Val  Trp Leu Thr 
    1580                 1585                 1590             


Glu Thr  Gly Met Ala Leu Leu  Arg Asn Leu Thr Met  Ser Pro Leu 
    1595                 1600                 1605             


His Lys  Arg Arg Gln Arg Arg  Gly Arg Leu Gly Leu  Pro Gly Glu 
    1610                 1615                 1620             


Ala Gly  Leu Glu Gly Ser Glu  Pro Ser Asp Ala Leu  Gly Pro Asp 
    1625                 1630                 1635             


Asp Lys  Lys Asp Gly Asp Leu  Asp Thr Asp Glu Leu  Leu Lys Gly 
    1640                 1645                 1650             


Glu Gly  Gly Val Glu His Met  Glu Cys Glu Ile Lys  Leu Glu Gly 
    1655                 1660                 1665             


Pro Val  Ser Pro Asp Val Glu  Pro Gly Lys Glu Glu  Thr Glu Glu 
    1670                 1675                 1680             


Ser Lys  Lys Arg Lys Arg Lys  Pro Tyr Arg Pro Gly  Ile Gly Gly 
    1685                 1690                 1695             


Phe Met  Val Arg Gln Arg Lys  Ser His Thr Arg Thr  Lys Lys Gly 
    1700                 1705                 1710             


Pro Ala  Ala Gln Ala Glu Val  Leu Ser Gly Asp Gly  Gln Pro Asp 
    1715                 1720                 1725             


Glu Val  Ile Pro Ala Asp Leu  Pro Ala Glu Gly Ala  Val Glu Gln 
    1730                 1735                 1740             


Ser Leu  Ala Glu Gly Asp Glu  Lys Lys Lys Gln Gln  Arg Arg Gly 
    1745                 1750                 1755             


Arg Lys  Lys Ser Lys Leu Glu  Asp Met Phe Pro Ala  Tyr Leu Gln 
    1760                 1765                 1770             


Glu Ala  Phe Phe Gly Lys Glu  Leu Leu Asp Leu Ser  Arg Lys Ala 
    1775                 1780                 1785             


Leu Phe  Ala Val Gly Val Gly  Arg Pro Ser Phe Gly  Leu Gly Thr 
    1790                 1795                 1800             


Pro Lys  Ala Lys Gly Asp Gly  Gly Ser Glu Arg Lys  Glu Leu Pro 
    1805                 1810                 1815             


Thr Ser  Gln Lys Gly Asp Asp  Gly Pro Asp Ile Ala  Asp Glu Glu 
    1820                 1825                 1830             


Ser Arg  Gly Leu Glu Gly Lys  Ala Asp Thr Pro Gly  Pro Glu Asp 
    1835                 1840                 1845             


Gly Gly  Val Lys Ala Ser Pro  Val Pro Ser Asp Pro  Glu Lys Pro 
    1850                 1855                 1860             


Gly Thr  Pro Gly Glu Gly Met  Leu Ser Ser Asp Leu  Asp Arg Ile 
    1865                 1870                 1875             


Ser Thr  Glu Glu Leu Pro Lys  Met Glu Ser Lys Asp  Leu Gln Gln 
    1880                 1885                 1890             


Leu Phe  Lys Asp Val Leu Gly  Ser Glu Arg Glu Gln  His Leu Gly 
    1895                 1900                 1905             


Cys Gly  Thr Pro Gly Leu Glu  Gly Ser Arg Thr Pro  Leu Gln Arg 
    1910                 1915                 1920             


Pro Phe  Leu Gln Gly Gly Leu  Pro Leu Gly Asn Leu  Pro Ser Ser 
    1925                 1930                 1935             


Ser Pro  Met Asp Ser Tyr Pro  Gly Leu Cys Gln Ser  Pro Phe Leu 
    1940                 1945                 1950             


Asp Ser  Arg Glu Arg Gly Gly  Phe Phe Ser Pro Glu  Pro Gly Glu 
    1955                 1960                 1965             


Pro Asp  Ser Pro Trp Thr Gly  Ser Gly Gly Thr Thr  Pro Ser Thr 
    1970                 1975                 1980             


Pro Thr  Thr Pro Thr Thr Glu  Gly Glu Gly Asp Gly  Leu Ser Tyr 
    1985                 1990                 1995             


Asn Gln  Arg Ser Leu Gln Arg  Trp Glu Lys Asp Glu  Glu Leu Gly 
    2000                 2005                 2010             


Gln Leu  Ser Thr Ile Ser Pro  Val Leu Tyr Ala Asn  Ile Asn Phe 
    2015                 2020                 2025             


Pro Asn  Leu Lys Gln Asp Tyr  Pro Asp Trp Ser Ser  Arg Cys Lys 
    2030                 2035                 2040             


Gln Ile  Met Lys Leu Trp Arg  Lys Val Pro Ala Ala  Asp Lys Ala 
    2045                 2050                 2055             


Pro Tyr  Leu Gln Lys Ala Lys  Asp Asn Arg Ala Ala  His Arg Ile 
    2060                 2065                 2070             


Asn Lys  Val Gln Lys Gln Ala  Glu Ser Gln Ile Asn  Lys Gln Thr 
    2075                 2080                 2085             


Lys Val  Gly Asp Ile Ala Arg  Lys Thr Asp Arg Pro  Ala Leu His 
    2090                 2095                 2100             


Leu Arg  Ile Pro Pro Gln Pro  Gly Ala Leu Gly Ser  Pro Pro Pro 
    2105                 2110                 2115             


Ala Ala  Ala Pro Thr Ile Phe  Ile Gly Ser Pro Thr  Thr Pro Ala 
    2120                 2125                 2130             


Gly Leu  Ser Thr Ser Ala Asp  Gly Phe Leu Lys Pro  Pro Ala Gly 
    2135                 2140                 2145             


Ser Val  Pro Gly Pro Asp Ser  Pro Gly Glu Leu Phe  Leu Lys Leu 
    2150                 2155                 2160             


Pro Pro  Gln Val Pro Ala Gln  Val Pro Ser Gln Asp  Pro Phe Gly 
    2165                 2170                 2175             


Leu Ala  Pro Ala Tyr Pro Leu  Glu Pro Arg Phe Pro  Thr Ala Pro 
    2180                 2185                 2190             


Pro Thr  Tyr Pro Pro Tyr Pro  Ser Pro Thr Gly Ala  Pro Ala Gln 
    2195                 2200                 2205             


Pro Pro  Met Leu Gly Ala Ser  Ser Arg Pro Gly Ala  Gly Gln Pro 
    2210                 2215                 2220             


Gly Glu  Phe His Thr Thr Pro  Pro Gly Thr Pro Arg  His Gln Pro 
    2225                 2230                 2235             


Ser Thr  Pro Asp Pro Phe Leu  Lys Pro Arg Cys Pro  Ser Leu Asp 
    2240                 2245                 2250             


Asn Leu  Ala Val Pro Glu Ser  Pro Gly Val Gly Gly  Gly Lys Ala 
    2255                 2260                 2265             


Ser Glu  Pro Leu Leu Ser Pro  Pro Pro Phe Gly Glu  Ser Arg Lys 
    2270                 2275                 2280             


Ala Leu  Glu Val Lys Lys Glu  Glu Leu Gly Ala Ser  Ser Pro Ser 
    2285                 2290                 2295             


Tyr Gly  Pro Pro Asn Leu Gly  Phe Val Asp Ser Pro  Ser Ser Gly 
    2300                 2305                 2310             


Thr His  Leu Gly Gly Leu Glu  Leu Lys Thr Pro Asp  Val Phe Lys 
    2315                 2320                 2325             


Ala Pro  Leu Thr Pro Arg Ala  Ser Gln Val Glu Pro  Gln Ser Pro 
    2330                 2335                 2340             


Gly Leu  Gly Leu Arg Pro Gln  Glu Pro Pro Pro Ala  Gln Ala Leu 
    2345                 2350                 2355             


Ala Pro  Ser Pro Pro Ser His  Pro Asp Ile Phe Arg  Pro Gly Ser 
    2360                 2365                 2370             


Tyr Thr  Asp Pro Tyr Ala Gln  Pro Pro Leu Thr Pro  Arg Pro Gln 
    2375                 2380                 2385             


Pro Pro  Pro Pro Glu Ser Cys  Cys Ala Leu Pro Pro  Arg Ser Leu 
    2390                 2395                 2400             


Pro Ser  Asp Pro Phe Ser Arg  Val Pro Ala Ser Pro  Gln Ser Gln 
    2405                 2410                 2415             


Ser Ser  Ser Gln Ser Pro Leu  Thr Pro Arg Pro Leu  Ser Ala Glu 
    2420                 2425                 2430             


Ala Phe  Cys Pro Ser Pro Val  Thr Pro Arg Phe Gln  Ser Pro Asp 
    2435                 2440                 2445             


Pro Tyr  Ser Arg Pro Pro Ser  Arg Pro Gln Ser Arg  Asp Pro Phe 
    2450                 2455                 2460             


Ala Pro  Leu His Lys Pro Pro  Arg Pro Gln Pro Pro  Glu Val Ala 
    2465                 2470                 2475             


Phe Lys  Ala Gly Ser Leu Ala  His Thr Ser Leu Gly  Ala Gly Gly 
    2480                 2485                 2490             


Phe Pro  Ala Ala Leu Pro Ala  Gly Pro Ala Gly Glu  Leu His Ala 
    2495                 2500                 2505             


Lys Val  Pro Ser Gly Gln Pro  Pro Asn Phe Val Arg  Ser Pro Gly 
    2510                 2515                 2520             


Thr Gly  Ala Phe Val Gly Thr  Pro Ser Pro Met Arg  Phe Thr Phe 
    2525                 2530                 2535             


Pro Gln  Ala Val Gly Glu Pro  Ser Leu Lys Pro Pro  Val Pro Gln 
    2540                 2545                 2550             


Pro Gly  Leu Pro Pro Pro His  Gly Ile Asn Ser His  Phe Gly Pro 
    2555                 2560                 2565             


Gly Pro  Thr Leu Gly Lys Pro  Gln Ser Thr Asn Tyr  Thr Val Ala 
    2570                 2575                 2580             


Thr Gly  Asn Phe His Pro Ser  Gly Ser Pro Leu Gly  Pro Ser Ser 
    2585                 2590                 2595             


Gly Ser  Thr Gly Glu Ser Tyr  Gly Leu Ser Pro Leu  Arg Pro Pro 
    2600                 2605                 2610             


Ser Val  Leu Pro Pro Pro Ala  Pro Asp Gly Ser Leu  Pro Tyr Leu 
    2615                 2620                 2625             


Ser His  Gly Ala Ser Gln Arg  Ser Gly Ile Thr Ser  Pro Val Glu 
    2630                 2635                 2640             


Lys Arg  Glu Asp Pro Gly Thr  Gly Met Gly Ser Ser  Leu Ala Thr 
    2645                 2650                 2655             


Ala Glu  Leu Pro Gly Thr Gln  Asp Pro Gly Met Ser  Gly Leu Ser 
    2660                 2665                 2670             


Gln Thr  Glu Leu Glu Lys Gln  Arg Gln Arg Gln Arg  Leu Arg Glu 
    2675                 2680                 2685             


Leu Leu  Ile Arg Gln Gln Ile  Gln Arg Asn Thr Leu  Arg Gln Glu 
    2690                 2695                 2700             


Lys Glu  Thr Ala Ala Ala Ala  Ala Gly Ala Val Gly  Pro Pro Gly 
    2705                 2710                 2715             


Ser Trp  Gly Ala Glu Pro Ser  Ser Pro Ala Phe Glu  Gln Leu Ser 
    2720                 2725                 2730             


Arg Gly  Gln Thr Pro Phe Ala  Gly Thr Gln Asp Lys  Ser Ser Leu 
    2735                 2740                 2745             


Val Gly  Leu Pro Pro Ser Lys  Leu Ser Gly Pro Ile  Leu Gly Pro 
    2750                 2755                 2760             


Gly Ser  Phe Pro Ser Asp Asp  Arg Leu Ser Arg Pro  Pro Pro Pro 
    2765                 2770                 2775             


Ala Thr  Pro Ser Ser Met Asp  Val Asn Ser Arg Gln  Leu Val Gly 
    2780                 2785                 2790             


Gly Ser  Gln Ala Phe Tyr Gln  Arg Ala Pro Tyr Pro  Gly Ser Leu 
    2795                 2800                 2805             


Pro Leu  Gln Gln Gln Gln Gln  Gln Leu Trp Gln Gln  Gln Gln Ala 
    2810                 2815                 2820             


Thr Ala  Ala Thr Ser Met Arg  Phe Ala Met Ser Ala  Arg Phe Pro 
    2825                 2830                 2835             


Ser Thr  Pro Gly Pro Glu Leu  Gly Arg Gln Ala Leu  Gly Ser Pro 
    2840                 2845                 2850             


Leu Ala  Gly Ile Ser Thr Arg  Leu Pro Gly Pro Gly  Glu Pro Val 
    2855                 2860                 2865             


Pro Gly  Pro Ala Gly Pro Ala  Gln Phe Ile Glu Leu  Arg His Asn 
    2870                 2875                 2880             


Val Gln  Lys Gly Leu Gly Pro  Gly Gly Thr Pro Phe  Pro Gly Gln 
    2885                 2890                 2895             


Gly Pro  Pro Gln Arg Pro Arg  Phe Tyr Pro Val Ser  Glu Asp Pro 
    2900                 2905                 2910             


His Arg  Leu Ala Pro Glu Gly  Leu Arg Gly Leu Ala  Val Ser Gly 
    2915                 2920                 2925             


Leu Pro  Pro Gln Lys Pro Ser  Ala Pro Pro Ala Pro  Glu Leu Asn 
    2930                 2935                 2940             


Asn Ser  Leu His Pro Thr Pro  His Thr Lys Gly Pro  Thr Leu Pro 
    2945                 2950                 2955             


Thr Gly  Leu Glu Leu Val Asn  Arg Pro Pro Ser Ser  Thr Glu Leu 
    2960                 2965                 2970             


Gly Arg  Pro Asn Pro Leu Ala  Leu Glu Ala Gly Lys  Leu Pro Cys 
    2975                 2980                 2985             


Glu Asp  Pro Glu Leu Asp Asp  Asp Phe Asp Ala His  Lys Ala Leu 
    2990                 2995                 3000             


Glu Asp  Asp Glu Glu Leu Ala  His Leu Gly Leu Gly  Val Asp Val 
    3005                 3010                 3015             


Ala Lys  Gly Asp Asp Glu Leu  Gly Thr Leu Glu Asn  Leu Glu Thr 
    3020                 3025                 3030             


Asn Asp  Pro His Leu Asp Asp  Leu Leu Asn Gly Asp  Glu Phe Asp 
    3035                 3040                 3045             


Leu Leu  Ala Tyr Thr Asp Pro  Glu Leu Asp Thr Gly  Asp Lys Lys 
    3050                 3055                 3060             


Asp Ile  Phe Asn Glu His Leu  Arg Leu Val Glu Ser  Ala Asn Glu 
    3065                 3070                 3075             


Lys Ala  Glu Arg Glu Ala Leu  Leu Arg Gly Val Glu  Pro Gly Pro 
    3080                 3085                 3090             


Leu Gly  Pro Glu Glu Arg Pro  Pro Pro Ala Ala Asp  Ala Ser Glu 
    3095                 3100                 3105             


Pro Arg  Leu Ala Ser Val Leu  Pro Glu Val Lys Pro  Lys Val Glu 
    3110                 3115                 3120             


Glu Gly  Gly Arg His Pro Ser  Pro Cys Gln Phe Thr  Ile Ala Thr 
    3125                 3130                 3135             


Pro Lys  Val Glu Pro Ala Pro  Ala Ala Asn Ser Leu  Gly Leu Gly 
    3140                 3145                 3150             


Leu Lys  Pro Gly Gln Ser Met  Met Gly Ser Arg Asp  Thr Arg Met 
    3155                 3160                 3165             


Gly Thr  Gly Pro Phe Ser Ser  Ser Gly His Thr Ala  Glu Lys Ala 
    3170                 3175                 3180             


Ser Phe  Gly Ala Thr Gly Gly  Pro Pro Ala His Leu  Leu Thr Pro 
    3185                 3190                 3195             


Ser Pro  Leu Ser Gly Pro Gly  Gly Ser Ser Leu Leu  Glu Lys Phe 
    3200                 3205                 3210             


Glu Leu  Glu Ser Gly Ala Leu  Thr Leu Pro Gly Gly  Pro Ala Ala 
    3215                 3220                 3225             


Ser Gly  Asp Glu Leu Asp Lys  Met Glu Ser Ser Leu  Val Ala Ser 
    3230                 3235                 3240             


Glu Leu  Pro Leu Leu Ile Glu  Asp Leu Leu Glu His  Glu Lys Lys 
    3245                 3250                 3255             


Glu Leu  Gln Lys Lys Gln Gln  Leu Ser Ala Gln Leu  Gln Pro Ala 
    3260                 3265                 3270             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln His Ser Leu  Leu Ser Ala 
    3275                 3280                 3285             


Pro Gly  Pro Ala Gln Ala Met  Ser Leu Pro His Glu  Gly Ser Ser 
    3290                 3295                 3300             


Pro Ser  Leu Ala Gly Ser Gln  Gln Gln Leu Ser Leu  Gly Leu Ala 
    3305                 3310                 3315             


Gly Ala  Arg Gln Pro Gly Leu  Pro Gln Pro Leu Met  Pro Thr Gln 
    3320                 3325                 3330             


Pro Pro  Ala His Ala Leu Gln  Gln Arg Leu Ala Pro  Ser Met Ala 
    3335                 3340                 3345             


Met Val  Ser Asn Gln Gly His  Met Leu Ser Gly Gln  His Gly Gly 
    3350                 3355                 3360             


Gln Ala  Gly Leu Val Pro Gln  Gln Ser Ser Gln Pro  Val Leu Ser 
    3365                 3370                 3375             


Gln Lys  Pro Met Gly Thr Met  Pro Pro Ser Met Cys  Met Lys Pro 
    3380                 3385                 3390             


Gln Gln  Leu Ala Met Gln Gln  Gln Leu Ala Asn Ser  Phe Phe Pro 
    3395                 3400                 3405             


Asp Thr  Asp Leu Asp Lys Phe  Ala Ala Glu Asp Ile  Ile Asp Pro 
    3410                 3415                 3420             


Ile Ala  Lys Ala Lys Met Val  Ala Leu Lys Gly Ile  Lys Lys Val 
    3425                 3430                 3435             


Met Ala  Gln Gly Ser Ile Gly  Val Ala Pro Gly Met  Asn Arg Gln 
    3440                 3445                 3450             


Gln Val  Ser Leu Leu Ala Gln  Arg Leu Ser Gly Gly  Pro Ser Ser 
    3455                 3460                 3465             


Asp Leu  Gln Asn His Val Ala  Ala Gly Ser Gly Gln  Glu Arg Ser 
    3470                 3475                 3480             


Ala Gly  Asp Pro Ser Gln Pro  Arg Pro Asn Pro Pro  Thr Phe Ala 
    3485                 3490                 3495             


Gln Gly  Val Ile Asn Glu Ala  Asp Gln Arg Gln Tyr  Glu Glu Trp 
    3500                 3505                 3510             


Leu Phe  His Thr Gln Gln Leu  Leu Gln Met Gln Leu  Lys Val Leu 
    3515                 3520                 3525             


Glu Glu  Gln Ile Gly Val His  Arg Lys Ser Arg Lys  Ala Leu Cys 
    3530                 3535                 3540             


Ala Lys  Gln Arg Thr Ala Lys  Lys Ala Gly Arg Glu  Phe Pro Glu 
    3545                 3550                 3555             


Ala Asp  Ala Glu Lys Leu Lys  Leu Val Thr Glu Gln  Gln Ser Lys 
    3560                 3565                 3570             


Ile Gln  Lys Gln Leu Asp Gln  Val Arg Lys Gln Gln  Lys Glu His 
    3575                 3580                 3585             


Thr Asn  Leu Met Ala Glu Tyr  Arg Asn Lys Gln Gln  Gln Gln Gln 
    3590                 3595                 3600             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln His Ser Ala  Val Leu Ala 
    3605                 3610                 3615             


Leu Ser  Pro Ser Gln Ser Pro  Arg Leu Leu Thr Lys  Leu Pro Gly 
    3620                 3625                 3630             


Gln Leu  Leu Pro Gly His Gly  Leu Gln Pro Pro Gln  Gly Pro Pro 
    3635                 3640                 3645             


Gly Gly  Gln Ala Gly Gly Leu  Arg Leu Thr Pro Gly  Gly Met Ala 
    3650                 3655                 3660             


Leu Pro  Gly Gln Pro Gly Gly  Pro Phe Leu Asn Thr  Ala Leu Ala 
    3665                 3670                 3675             


Gln Gln  Gln Gln Gln Gln His  Ser Gly Gly Ala Gly  Ser Leu Ala 
    3680                 3685                 3690             


Gly Pro  Ser Gly Gly Phe Phe  Pro Gly Asn Leu Ala  Leu Arg Ser 
    3695                 3700                 3705             


Leu Gly  Pro Asp Ser Arg Leu  Leu Gln Glu Arg Gln  Leu Gln Leu 
    3710                 3715                 3720             


Gln Gln  Gln Arg Met Gln Leu  Ala Gln Lys Leu Gln  Gln Gln Gln 
    3725                 3730                 3735             


Gln Gln  Gln Gln Gln Gln Gln  His Leu Leu Gly Gln  Val Ala Ile 
    3740                 3745                 3750             


Gln Gln  Gln Gln Gln Gln Gly  Pro Gly Val Gln Thr  Asn Gln Ala 
    3755                 3760                 3765             


Leu Gly  Pro Lys Pro Gln Gly  Leu Met Pro Pro Ser  Ser His Gln 
    3770                 3775                 3780             


Gly Leu  Leu Val Gln Gln Leu  Ser Pro Gln Pro Pro  Gln Gly Pro 
    3785                 3790                 3795             


Gln Gly  Met Leu Gly Pro Ala  Gln Val Ala Val Leu  Gln Gln Gln 
    3800                 3805                 3810             


His Pro  Gly Ala Leu Gly Pro  Gln Gly Pro His Arg  Gln Val Leu 
    3815                 3820                 3825             


Met Thr  Gln Ser Arg Val Leu  Ser Ser Pro Gln Leu  Ala Gln Gln 
    3830                 3835                 3840             


Gly Gln  Gly Leu Met Gly His  Arg Leu Val Thr Ala  Gln Gln Gln 
    3845                 3850                 3855             


Gln Gln  Gln Gln Gln His Gln  Gln Gln Gly Ser Met  Ala Gly Leu 
    3860                 3865                 3870             


Ser His  Leu Gln Gln Ser Leu  Met Ser His Ser Gly  Gln Pro Lys 
    3875                 3880                 3885             


Leu Ser  Ala Gln Pro Met Gly  Ser Leu Gln Gln Leu  Gln Gln Gln 
    3890                 3895                 3900             


Gln Gln  Leu Gln Gln Gln Gln  Gln Leu Gln Gln Gln  Gln Gln Gln 
    3905                 3910                 3915             


Gln Leu  Gln Gln Gln Gln Gln  Leu Gln Gln Gln Gln  Leu Gln Gln 
    3920                 3925                 3930             


Gln Gln  Gln Gln Gln Gln Leu  Gln Gln Gln Gln Gln  Gln Gln Leu 
    3935                 3940                 3945             


Gln Gln  Gln Gln Gln Gln Leu  Gln Gln Gln Gln Gln  Gln Gln Gln 
    3950                 3955                 3960             


Gln Gln  Phe Gln Gln Gln Gln  Gln Gln Gln Gln Met  Gly Leu Leu 
    3965                 3970                 3975             


Asn Gln  Ser Arg Thr Leu Leu  Ser Pro Gln Gln Gln  Gln Gln Gln 
    3980                 3985                 3990             


Gln Val  Ala Leu Gly Pro Gly  Met Pro Ala Lys Pro  Leu Gln His 
    3995                 4000                 4005             


Phe Ser  Ser Pro Gly Ala Leu  Gly Pro Thr Leu Leu  Leu Thr Gly 
    4010                 4015                 4020             


Lys Glu  Gln Asn Thr Val Asp  Pro Ala Val Ser Ser  Glu Ala Thr 
    4025                 4030                 4035             


Glu Gly  Pro Ser Thr His Gln  Gly Gly Pro Leu Ala  Ile Gly Thr 
    4040                 4045                 4050             


Thr Pro  Glu Ser Met Ala Thr  Glu Pro Gly Glu Val  Lys Pro Ser 
    4055                 4060                 4065             


Leu Ser  Gly Asp Ser Gln Leu  Leu Leu Val Gln Pro  Gln Pro Gln 
    4070                 4075                 4080             


Pro Gln  Pro Ser Ser Leu Gln  Leu Gln Pro Pro Leu  Arg Leu Pro 
    4085                 4090                 4095             


Gly Gln  Gln Gln Gln Gln Val  Ser Leu Leu His Thr  Ala Gly Gly 
    4100                 4105                 4110             


Gly Ser  His Gly Gln Leu Gly  Ser Gly Ser Ser Ser  Glu Ala Ser 
    4115                 4120                 4125             


Ser Val  Pro His Leu Leu Ala  Gln Pro Ser Val Ser  Leu Gly Asp 
    4130                 4135                 4140             


Gln Pro  Gly Ser Met Thr Gln  Asn Leu Leu Gly Pro  Gln Gln Pro 
    4145                 4150                 4155             


Met Leu  Glu Arg Pro Met Gln  Asn Asn Thr Gly Pro  Gln Pro Pro 
    4160                 4165                 4170             


Lys Pro  Gly Pro Val Leu Gln  Ser Gly Gln Gly Leu  Pro Gly Val 
    4175                 4180                 4185             


Gly Ile  Met Pro Thr Val Gly  Gln Leu Arg Ala Gln  Leu Gln Gly 
    4190                 4195                 4200             


Val Leu  Ala Lys Asn Pro Gln  Leu Arg His Leu Ser  Pro Gln Gln 
    4205                 4210                 4215             


Gln Gln  Gln Leu Gln Ala Leu  Leu Met Gln Arg Gln  Leu Gln Gln 
    4220                 4225                 4230             


Ser Gln  Ala Val Arg Gln Thr  Pro Pro Tyr Gln Glu  Pro Gly Thr 
    4235                 4240                 4245             


Gln Thr  Ser Pro Leu Gln Gly  Leu Leu Gly Cys Gln  Pro Gln Leu 
    4250                 4255                 4260             


Gly Gly  Phe Pro Gly Pro Gln  Thr Gly Pro Leu Gln  Glu Leu Gly 
    4265                 4270                 4275             


Ala Gly  Pro Arg Pro Gln Gly  Pro Pro Arg Leu Pro  Ala Pro Pro 
    4280                 4285                 4290             


Gly Ala  Leu Ser Thr Gly Pro  Val Leu Gly Pro Val  His Pro Thr 
    4295                 4300                 4305             


Pro Pro  Pro Ser Ser Pro Gln  Glu Pro Lys Arg Pro  Ser Gln Leu 
    4310                 4315                 4320             


Pro Ser  Pro Ser Ser Gln Leu  Pro Thr Glu Ala Gln  Leu Pro Pro 
    4325                 4330                 4335             


Thr His  Pro Gly Thr Pro Lys  Pro Gln Gly Pro Thr  Leu Glu Pro 
    4340                 4345                 4350             


Pro Pro  Gly Arg Val Ser Pro  Ala Ala Ala Gln Leu  Ala Asp Thr 
    4355                 4360                 4365             


Leu Phe  Ser Lys Gly Leu Gly  Pro Trp Asp Pro Pro  Asp Asn Leu 
    4370                 4375                 4380             


Ala Glu  Thr Gln Lys Pro Glu  Gln Ser Ser Leu Val  Pro Gly His 
    4385                 4390                 4395             


Leu Asp  Gln Val Asn Gly Gln  Val Val Pro Glu Ala  Ser Gln Leu 
    4400                 4405                 4410             


Ser Ile  Lys Gln Glu Pro Arg  Glu Glu Pro Cys Ala  Leu Gly Ala 
    4415                 4420                 4425             


Gln Ser  Val Lys Arg Glu Ala  Asn Gly Glu Pro Ile  Gly Ala Pro 
    4430                 4435                 4440             


Gly Thr  Ser Asn His Leu Leu  Leu Ala Gly Pro Arg  Ser Glu Ala 
    4445                 4450                 4455             


Gly His  Leu Leu Leu Gln Lys  Leu Leu Arg Ala Lys  Asn Val Gln 
    4460                 4465                 4470             


Leu Ser  Thr Gly Arg Gly Ser  Glu Gly Leu Arg Ala  Glu Ile Asn 
    4475                 4480                 4485             


Gly His  Ile Asp Ser Lys Leu  Ala Gly Leu Glu Gln  Lys Leu Gln 
    4490                 4495                 4500             


Gly Thr  Pro Ser Asn Lys Glu  Asp Ala Ala Ala Arg  Lys Pro Leu 
    4505                 4510                 4515             


Thr Pro  Lys Pro Lys Arg Val  Gln Lys Ala Ser Asp  Arg Leu Val 
    4520                 4525                 4530             


Ser Ser  Arg Lys Lys Leu Arg  Lys Glu Asp Gly Val  Arg Ala Ser 
    4535                 4540                 4545             


Glu Ala  Leu Leu Lys Gln Leu  Lys Gln Glu Leu Ser  Leu Leu Pro 
    4550                 4555                 4560             


Leu Thr  Glu Pro Ala Ile Thr  Ala Asn Phe Ser Leu  Phe Ala Pro 
    4565                 4570                 4575             


Phe Gly  Ser Gly Cys Pro Val  Asn Gly Gln Ser Gln  Leu Arg Gly 
    4580                 4585                 4590             


Ala Phe  Gly Ser Gly Ala Leu  Pro Thr Gly Pro Asp  Tyr Tyr Ser 
    4595                 4600                 4605             


Gln Leu  Leu Thr Lys Asn Asn  Leu Ser Asn Pro Pro  Thr Pro Pro 
    4610                 4615                 4620             


Ser Ser  Leu Pro Pro Thr Pro  Pro Pro Ser Val Gln  Gln Lys Met 
    4625                 4630                 4635             


Val Asn  Gly Val Thr Pro Ser  Glu Glu Leu Gly Glu  His Pro Lys 
    4640                 4645                 4650             


Asp Ala  Ala Ser Ala Arg Asp  Ser Glu Arg Ala Leu  Arg Asp Thr 
    4655                 4660                 4665             


Ser Glu  Val Lys Ser Leu Asp  Leu Leu Ala Ala Leu  Pro Thr Pro 
    4670                 4675                 4680             


Pro His  Asn Gln Thr Glu Asp  Val Arg Met Glu Ser  Asp Glu Asp 
    4685                 4690                 4695             


Ser Asp  Ser Pro Asp Ser Ile  Val Pro Ala Ser Ser  Pro Glu Ser 
    4700                 4705                 4710             


Ile Leu  Gly Glu Glu Ala Pro  Arg Phe Pro His Leu  Gly Ser Gly 
    4715                 4720                 4725             


Arg Trp  Glu Gln Glu Asp Arg  Ala Leu Ser Pro Val  Ile Pro Leu 
    4730                 4735                 4740             


Ile Pro  Arg Ala Ser Ile Pro  Val Phe Pro Asp Thr  Lys Pro Tyr 
    4745                 4750                 4755             


Gly Ala  Leu Gly Leu Glu Val  Pro Gly Lys Leu Pro  Val Thr Thr 
    4760                 4765                 4770             


Trp Glu  Lys Gly Lys Gly Ser  Glu Val Ser Val Met  Leu Thr Val 
    4775                 4780                 4785             


Ser Ala  Ala Ala Ala Lys Asn  Leu Asn Gly Val Met  Val Ala Val 
    4790                 4795                 4800             


Ala Glu  Leu Leu Ser Met Lys  Ile Pro Asn Ser Tyr  Glu Val Leu 
    4805                 4810                 4815             


Phe Pro  Glu Ser Pro Ala Arg  Ala Gly Thr Glu Pro  Lys Lys Gly 
    4820                 4825                 4830             


Glu Ala  Glu Gly Pro Gly Gly  Lys Glu Lys Gly Leu  Glu Gly Lys 
    4835                 4840                 4845             


Ser Pro  Asp Thr Gly Pro Asp  Trp Leu Lys Gln Phe  Asp Ala Val 
    4850                 4855                 4860             


Leu Pro  Gly Tyr Thr Leu Lys  Ser Gln Leu Asp Ile  Leu Ser Leu 
    4865                 4870                 4875             


Leu Lys  Gln Glu Ser Pro Ala  Pro Glu Pro Pro Thr  Gln His Ser 
    4880                 4885                 4890             


Tyr Thr  Tyr Asn Val Ser Asn  Leu Asp Val Arg Gln  Leu Ser Ala 
    4895                 4900                 4905             


Pro Pro  Pro Glu Glu Pro Ser  Pro Pro Pro Ser Pro  Leu Ala Pro 
    4910                 4915                 4920             


Ser Pro  Ala Ser Pro Pro Thr  Glu Pro Leu Val Glu  Leu Pro Thr 
    4925                 4930                 4935             


Glu Pro  Leu Ala Glu Pro Pro  Val Pro Ser Pro Leu  Pro Leu Ala 
    4940                 4945                 4950             


Ser Ser  Pro Glu Ser Ala Arg  Pro Lys Pro Arg Ala  Arg Pro Pro 
    4955                 4960                 4965             


Glu Glu  Gly Glu Asp Ser Arg  Pro Pro Arg Leu Lys  Lys Trp Lys 
    4970                 4975                 4980             


Gly Val  Arg Trp Lys Arg Leu  Arg Leu Leu Leu Thr  Ile Gln Lys 
    4985                 4990                 4995             


Gly Ser  Gly Arg Gln Glu Asp  Glu Arg Glu Val Ala  Glu Phe Met 
    5000                 5005                 5010             


Glu Gln  Leu Gly Thr Ala Leu  Arg Pro Asp Lys Val  Pro Arg Asp 
    5015                 5020                 5025             


Met Arg  Arg Cys Cys Phe Cys  His Glu Glu Gly Asp  Gly Ala Thr 
    5030                 5035                 5040             


Asp Gly  Pro Ala Arg Leu Leu  Asn Leu Asp Leu Asp  Leu Trp Val 
    5045                 5050                 5055             


His Leu  Asn Cys Ala Leu Trp  Ser Thr Glu Val Tyr  Glu Thr Gln 
    5060                 5065                 5070             


Gly Gly  Ala Leu Met Asn Val  Glu Val Ala Leu His  Arg Gly Leu 
    5075                 5080                 5085             


Leu Thr  Lys Cys Ser Leu Cys  Gln Arg Thr Gly Ala  Thr Ser Ser 
    5090                 5095                 5100             


Cys Asn  Arg Met Arg Cys Pro  Asn Val Tyr His Phe  Ala Cys Ala 
    5105                 5110                 5115             


Ile Arg  Ala Lys Cys Met Phe  Phe Lys Asp Lys Thr  Met Leu Cys 
    5120                 5125                 5130             


Pro Met  His Lys Ile Lys Gly  Pro Cys Glu Gln Glu  Leu Ser Ser 
    5135                 5140                 5145             


Phe Ala  Val Phe Arg Arg Val  Tyr Ile Glu Arg Asp  Glu Val Lys 
    5150                 5155                 5160             


Gln Ile  Ala Ser Ile Ile Gln  Arg Gly Glu Arg Leu  His Met Phe 
    5165                 5170                 5175             


Arg Val  Gly Gly Leu Val Phe  His Ala Ile Gly Gln  Leu Leu Pro 
    5180                 5185                 5190             


His Gln  Met Ala Asp Phe His  Ser Ala Thr Ala Leu  Tyr Pro Val 
    5195                 5200                 5205             


Gly Tyr  Glu Ala Thr Arg Ile  Tyr Trp Ser Leu Arg  Thr Asn Asn 
    5210                 5215                 5220             


Arg Arg  Cys Cys Tyr Arg Cys  Ser Ile Gly Glu Asn  Asn Gly Arg 
    5225                 5230                 5235             


Pro Glu  Phe Val Ile Lys Val  Ile Glu Gln Gly Leu  Glu Asp Leu 
    5240                 5245                 5250             


Val Phe  Thr Asp Ala Ser Pro  Gln Ala Val Trp Asn  Arg Ile Ile 
    5255                 5260                 5265             


Glu Pro  Val Ala Ala Met Arg  Lys Glu Ala Asp Met  Leu Arg Leu 
    5270                 5275                 5280             


Phe Pro  Glu Tyr Leu Lys Gly  Glu Glu Leu Phe Gly  Leu Thr Val 
    5285                 5290                 5295             


His Ala  Val Leu Arg Ile Ala  Glu Ser Leu Pro Gly  Val Glu Ser 
    5300                 5305                 5310             


Cys Gln  Asn Tyr Leu Phe Arg  Tyr Gly Arg His Pro  Leu Met Glu 
    5315                 5320                 5325             


Leu Pro  Leu Met Ile Asn Pro  Thr Gly Cys Ala Arg  Ser Glu Pro 
    5330                 5335                 5340             


Lys Ile  Leu Thr His Tyr Lys  Arg Pro His Thr Leu  Asn Ser Thr 
    5345                 5350                 5355             


Ser Met  Ser Lys Ala Tyr Gln  Ser Thr Phe Thr Gly  Glu Thr Asn 
    5360                 5365                 5370             


Thr Pro  Tyr Ser Lys Gln Phe  Val His Ser Lys Ser  Ser Gln Tyr 
    5375                 5380                 5385             


Arg Arg  Leu Arg Thr Glu Trp  Lys Asn Asn Val Tyr  Leu Ala Arg 
    5390                 5395                 5400             


Ser Arg  Ile Gln Gly Leu Gly  Leu Tyr Ala Ala Lys  Asp Leu Glu 
    5405                 5410                 5415             


Lys His  Thr Met Val Ile Glu  Tyr Ile Gly Thr Ile  Ile Arg Asn 
    5420                 5425                 5430             


Glu Val  Ala Asn Arg Arg Glu  Lys Ile Tyr Glu Glu  Gln Asn Arg 
    5435                 5440                 5445             


Gly Ile  Tyr Met Phe Arg Ile  Asn Asn Glu His Val  Ile Asp Ala 
    5450                 5455                 5460             


Thr Leu  Thr Gly Gly Pro Ala  Arg Tyr Ile Asn His  Ser Cys Ala 
    5465                 5470                 5475             


Pro Asn  Cys Val Ala Glu Val  Val Thr Phe Asp Lys  Glu Asp Lys 
    5480                 5485                 5490             


Ile Ile  Ile Ile Ser Ser Arg  Arg Ile Pro Lys Gly  Glu Glu Leu 
    5495                 5500                 5505             


Thr Tyr  Asp Tyr Gln Phe Asp  Phe Glu Asp Asp Gln  His Lys Ile 
    5510                 5515                 5520             


Pro Cys  His Cys Gly Ala Trp  Asn Cys Arg Lys Trp  Met Asn 
    5525                 5530                 5535         


<210>  5996
<211>  1858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KMT2E__Homo_sapiens__NP_061152

<400>  5996

Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr 
1               5                   10                  15      


Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser 
        35                  40                  45              


Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His 
    50                  55                  60                  


Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro 
65                  70                  75                  80  


Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn 
                85                  90                  95      


Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly 
            100                 105                 110         


Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp 
        115                 120                 125             


Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile 
    130                 135                 140                 


Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys 
145                 150                 155                 160 


Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu 
                165                 170                 175     


Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr 
            180                 185                 190         


Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His 
        195                 200                 205             


Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn 
    210                 215                 220                 


Asp Lys Arg Arg Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys 
225                 230                 235                 240 


Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys 
                245                 250                 255     


Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly 
            260                 265                 270         


Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn 
        275                 280                 285             


Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala 
    290                 295                 300                 


Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp 
305                 310                 315                 320 


Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile 
                325                 330                 335     


Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp 
            340                 345                 350         


Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe 
        355                 360                 365             


Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe 
    370                 375                 380                 


Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe 
385                 390                 395                 400 


Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu 
                405                 410                 415     


Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser 
            420                 425                 430         


Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe 
        435                 440                 445             


Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu 
    450                 455                 460                 


Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn 
465                 470                 475                 480 


Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys 
                485                 490                 495     


Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp 
            500                 505                 510         


Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg 
        515                 520                 525             


Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp 
    530                 535                 540                 


Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu 
545                 550                 555                 560 


Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Thr Arg 
                565                 570                 575     


Glu Glu Arg Lys Met Glu Ala Ile Leu Gln Ala Phe Ala Arg Leu Glu 
            580                 585                 590         


Lys Arg Glu Lys Arg Arg Glu Gln Ala Leu Glu Arg Ile Ser Thr Ala 
        595                 600                 605             


Lys Thr Glu Val Lys Thr Glu Cys Lys Asp Thr Gln Ile Val Ser Asp 
    610                 615                 620                 


Ala Glu Val Ile Gln Glu Gln Ala Lys Glu Glu Asn Ala Ser Lys Pro 
625                 630                 635                 640 


Thr Pro Ala Lys Val Asn Arg Thr Lys Gln Arg Lys Ser Phe Ser Arg 
                645                 650                 655     


Ser Arg Thr His Ile Gly Gln Gln Arg Arg Arg His Arg Thr Val Ser 
            660                 665                 670         


Met Cys Ser Asp Ile Gln Pro Ser Ser Pro Asp Ile Glu Val Thr Ser 
        675                 680                 685             


Gln Gln Asn Asp Ile Glu Asn Thr Val Leu Thr Ile Glu Pro Glu Thr 
    690                 695                 700                 


Glu Thr Ala Leu Ala Glu Ile Ile Thr Glu Thr Glu Val Pro Ala Leu 
705                 710                 715                 720 


Asn Lys Cys Pro Thr Lys Tyr Pro Lys Thr Lys Lys His Leu Val Asn 
                725                 730                 735     


Glu Trp Leu Ser Glu Lys Asn Glu Lys Thr Gly Lys Pro Ser Asp Gly 
            740                 745                 750         


Leu Ser Glu Arg Pro Leu Arg Ile Thr Thr Asp Pro Glu Val Leu Ala 
        755                 760                 765             


Thr Gln Leu Asn Ser Leu Pro Gly Leu Thr Tyr Ser Pro His Val Tyr 
    770                 775                 780                 


Ser Thr Pro Lys His Tyr Ile Arg Phe Thr Ser Pro Phe Leu Ser Glu 
785                 790                 795                 800 


Lys Arg Arg Arg Lys Glu Pro Thr Glu Asn Ile Ser Gly Ser Cys Lys 
                805                 810                 815     


Lys Arg Trp Leu Lys Gln Ala Leu Glu Glu Glu Asn Ser Ala Ile Leu 
            820                 825                 830         


His Arg Phe Asn Ser Pro Cys Gln Glu Arg Ser Arg Ser Pro Ala Val 
        835                 840                 845             


Asn Gly Glu Asn Lys Ser Pro Leu Leu Leu Asn Asp Ser Cys Ser Leu 
    850                 855                 860                 


Pro Asp Leu Thr Thr Pro Leu Lys Lys Arg Arg Phe Tyr Gln Leu Leu 
865                 870                 875                 880 


Asp Ser Val Tyr Ser Glu Thr Ser Thr Pro Thr Pro Ser Pro Tyr Ala 
                885                 890                 895     


Thr Pro Thr His Thr Asp Ile Thr Pro Met Asp Pro Ser Phe Ala Thr 
            900                 905                 910         


Pro Pro Arg Ile Lys Ser Asp Asp Glu Thr Cys Arg Asn Gly Tyr Lys 
        915                 920                 925             


Pro Ile Tyr Ser Pro Val Thr Pro Val Thr Pro Gly Thr Pro Gly Asn 
    930                 935                 940                 


Thr Met His Phe Glu Asn Ile Ser Ser Pro Glu Ser Ser Pro Glu Ile 
945                 950                 955                 960 


Lys Arg Arg Thr Tyr Ser Gln Glu Gly Tyr Asp Arg Ser Ser Thr Met 
                965                 970                 975     


Leu Thr Leu Gly Pro Phe Arg Asn Ser Asn Leu Thr Glu Leu Gly Leu 
            980                 985                 990         


Gln Glu Ile Lys Thr Ile Gly Tyr  Thr Ser Pro Arg Ser  Arg Thr Glu 
        995                 1000                 1005             


Val Asn  Arg Gln Cys Pro Gly  Glu Lys Glu Pro Val  Ser Asp Leu 
    1010                 1015                 1020             


Gln Leu  Gly Leu Asp Ala Val  Glu Pro Thr Ala Leu  His Lys Thr 
    1025                 1030                 1035             


Leu Glu  Thr Pro Ala His Asp  Arg Ala Glu Pro Asn  Ser Gln Leu 
    1040                 1045                 1050             


Asp Ser  Thr His Ser Gly Arg  Gly Thr Met Tyr Ser  Ser Trp Val 
    1055                 1060                 1065             


Lys Ser  Pro Asp Arg Thr Gly  Val Asn Phe Ser Val  Asn Ser Asn 
    1070                 1075                 1080             


Leu Arg  Asp Leu Thr Pro Ser  His Gln Leu Glu Val  Gly Gly Gly 
    1085                 1090                 1095             


Phe Arg  Ile Ser Glu Ser Lys  Cys Leu Met Gln Asp  Asp Thr Arg 
    1100                 1105                 1110             


Gly Met  Phe Met Glu Thr Thr  Val Phe Cys Thr Ser  Glu Asp Gly 
    1115                 1120                 1125             


Leu Val  Ser Gly Phe Gly Arg  Thr Val Asn Asp Asn  Leu Ile Asp 
    1130                 1135                 1140             


Gly Asn  Cys Thr Pro Gln Asn  Pro Pro Gln Lys Lys  Lys Val Ser 
    1145                 1150                 1155             


Leu Leu  Glu Tyr Arg Lys Arg  Gln Arg Glu Ala Arg  Lys Ser Gly 
    1160                 1165                 1170             


Ser Lys  Thr Glu Asn Phe Pro  Leu Ile Ser Val Ser  Pro His Ala 
    1175                 1180                 1185             


Ser Gly  Ser Leu Ser Asn Asn  Gly Asp Gly Cys Ala  Ser Ser Asn 
    1190                 1195                 1200             


Asp Asn  Gly Glu Gln Val Asp  His Thr Ala Ser Leu  Pro Leu Pro 
    1205                 1210                 1215             


Thr Pro  Ala Thr Val Tyr Asn  Ala Thr Ser Glu Glu  Thr Ser Asn 
    1220                 1225                 1230             


Asn Cys  Pro Val Lys Asp Ala  Thr Ala Ser Glu Lys  Asn Glu Pro 
    1235                 1240                 1245             


Glu Val  Gln Trp Thr Ala Ser  Thr Ser Val Glu Gln  Val Arg Glu 
    1250                 1255                 1260             


Arg Ser  Tyr Gln Arg Ala Leu  Leu Leu Ser Asp His  Arg Lys Asp 
    1265                 1270                 1275             


Lys Asp  Ser Gly Gly Glu Ser  Pro Cys Val Ser Cys  Ser Pro Ser 
    1280                 1285                 1290             


His Val  Gln Ser Ser Pro Ser  Ser His Ser Asn His  Ile Pro Gln 
    1295                 1300                 1305             


Leu Gln  Ala Lys Gly Pro Val  Pro Ser Phe Ser Glu  Leu Met Glu 
    1310                 1315                 1320             


Asp Pro  Asp Pro Glu Asn Pro  Glu Pro Thr Thr Thr  Asn Glu Cys 
    1325                 1330                 1335             


Pro Ser  Pro Asp Thr Ser Gln  Asn Thr Cys Lys Ser  Pro Pro Lys 
    1340                 1345                 1350             


Met Ser  Lys Pro Gly Ser Pro  Gly Ser Val Ile Pro  Ala Gln Ala 
    1355                 1360                 1365             


His Gly  Lys Ile Phe Thr Lys  Pro Asp Pro Gln Trp  Asp Ser Thr 
    1370                 1375                 1380             


Val Ser  Ala Ser Glu Ala Glu  Asn Gly Val His Leu  Lys Thr Glu 
    1385                 1390                 1395             


Leu Gln  Gln Lys Gln Leu Ser  Asn Asn Asn Gln Ala  Leu Ser Lys 
    1400                 1405                 1410             


Asn His  Pro Pro Gln Thr His  Val Arg Asn Ser Ser  Glu Gln Leu 
    1415                 1420                 1425             


Ser Gln  Lys Leu Pro Ser Val  Pro Thr Lys Leu His  Cys Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Leu Glu Asn Pro  Pro Lys Ser Ser Thr  Pro His Thr 
    1445                 1450                 1455             


Pro Val  Gln His Gly Tyr Leu  Ser Pro Lys Pro Pro  Ser Gln Gln 
    1460                 1465                 1470             


Leu Gly  Ser Pro Tyr Arg Pro  His His Ser Gln Ser  Pro Gln Val 
    1475                 1480                 1485             


Gly Thr  Pro Gln Arg Glu Pro  Gln Arg Asn Phe Tyr  Pro Ala Ala 
    1490                 1495                 1500             


Gln Asn  Leu Pro Ala Asn Thr  Gln Gln Ala Thr Ser  Gly Thr Leu 
    1505                 1510                 1515             


Phe Thr  Gln Thr Pro Ser Gly  Gln Ser Ser Ala Thr  Tyr Ser Gln 
    1520                 1525                 1530             


Phe Asn  Gln Gln Ser Leu Asn  Ser Thr Ala Pro Pro  Pro Pro Pro 
    1535                 1540                 1545             


Pro Pro  Pro Pro Ser Ser Ser  Tyr Tyr Gln Asn Gln  Gln Pro Ser 
    1550                 1555                 1560             


Ala Asn  Phe Gln Asn Tyr Asn  Gln Leu Lys Gly Ser  Leu Ser Gln 
    1565                 1570                 1575             


Gln Thr  Val Phe Thr Ser Gly  Pro Asn Gln Ala Leu  Pro Gly Thr 
    1580                 1585                 1590             


Thr Ser  Gln Gln Thr Val Pro  Gly His His Val Thr  Pro Gly His 
    1595                 1600                 1605             


Phe Leu  Pro Ser Gln Asn Pro  Thr Ile His His Gln  Thr Ala Ala 
    1610                 1615                 1620             


Ala Val  Val Pro Pro Pro Pro  Pro Pro Pro Pro Ala  Pro Gly Pro 
    1625                 1630                 1635             


His Leu  Val Gln Gln Pro Asn  Ser His Gln Gln His  Ser Val Ala 
    1640                 1645                 1650             


His Val  Val Gly Pro Val His  Ala Val Thr Pro Gly  Ser His Ile 
    1655                 1660                 1665             


His Ser  Gln Thr Ala Gly His  His Leu Pro Pro Pro  Pro Pro Pro 
    1670                 1675                 1680             


Pro Gly  Pro Ala Pro His His  His Pro Pro Pro His  Pro Ser Thr 
    1685                 1690                 1695             


Gly Leu  Gln Gly Leu Gln Ala  Gln His Gln His Val  Val Asn Ser 
    1700                 1705                 1710             


Ala Pro  Pro Pro Pro Pro Pro  Pro Pro Pro Ser Ser  Val Leu Ala 
    1715                 1720                 1725             


Ser Gly  His His Thr Thr Ser  Ala Gln Ala Leu His  His Pro Pro 
    1730                 1735                 1740             


His Gln  Gly Pro Pro Leu Phe  Pro Ser Ser Ala His  Pro Thr Val 
    1745                 1750                 1755             


Pro Pro  Tyr Pro Ser Gln Ala  Thr His His Thr Thr  Leu Gly Pro 
    1760                 1765                 1770             


Gly Pro  Gln His Gln Pro Ser  Gly Thr Gly Pro His  Cys Pro Leu 
    1775                 1780                 1785             


Pro Val  Thr Gly Pro His Leu  Gln Pro Gln Gly Pro  Asn Ser Ile 
    1790                 1795                 1800             


Pro Thr  Pro Thr Ala Ser Gly  Phe Cys Pro His Pro  Gly Ser Val 
    1805                 1810                 1815             


Ala Leu  Pro His Gly Val Gln  Gly Pro Gln Gln Ala  Ser Pro Val 
    1820                 1825                 1830             


Pro Gly  Gln Ile Pro Ile His  Arg Ala Gln Val Pro  Pro Thr Phe 
    1835                 1840                 1845             


Gln Asn  Asn Tyr His Gly Ser  Gly Trp His 
    1850                 1855             


<210>  5997
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KNG1__Homo_sapiens__NP_000884

<400>  5997

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr Gln Glu Ser Gln Ser Glu Glu Ile Asp Cys Asn Asp Lys Asp 
            20                  25                  30          


Leu Phe Lys Ala Val Asp Ala Ala Leu Lys Lys Tyr Asn Ser Gln Asn 
        35                  40                  45              


Gln Ser Asn Asn Gln Phe Val Leu Tyr Arg Ile Thr Glu Ala Thr Lys 
    50                  55                  60                  


Thr Val Gly Ser Asp Thr Phe Tyr Ser Phe Lys Tyr Glu Ile Lys Glu 
65                  70                  75                  80  


Gly Asp Cys Pro Val Gln Ser Gly Lys Thr Trp Gln Asp Cys Glu Tyr 
                85                  90                  95      


Lys Asp Ala Ala Lys Ala Ala Thr Gly Glu Cys Thr Ala Thr Val Gly 
            100                 105                 110         


Lys Arg Ser Ser Thr Lys Phe Ser Val Ala Thr Gln Thr Cys Gln Ile 
        115                 120                 125             


Thr Pro Ala Glu Gly Pro Val Val Thr Ala Gln Tyr Asp Cys Leu Gly 
    130                 135                 140                 


Cys Val His Pro Ile Ser Thr Gln Ser Pro Asp Leu Glu Pro Ile Leu 
145                 150                 155                 160 


Arg His Gly Ile Gln Tyr Phe Asn Asn Asn Thr Gln His Ser Ser Leu 
                165                 170                 175     


Phe Met Leu Asn Glu Val Lys Arg Ala Gln Arg Gln Val Val Ala Gly 
            180                 185                 190         


Leu Asn Phe Arg Ile Thr Tyr Ser Ile Val Gln Thr Asn Cys Ser Lys 
        195                 200                 205             


Glu Asn Phe Leu Phe Leu Thr Pro Asp Cys Lys Ser Leu Trp Asn Gly 
    210                 215                 220                 


Asp Thr Gly Glu Cys Thr Asp Asn Ala Tyr Ile Asp Ile Gln Leu Arg 
225                 230                 235                 240 


Ile Ala Ser Phe Ser Gln Asn Cys Asp Ile Tyr Pro Gly Lys Asp Phe 
                245                 250                 255     


Val Gln Pro Pro Thr Lys Ile Cys Val Gly Cys Pro Arg Asp Ile Pro 
            260                 265                 270         


Thr Asn Ser Pro Glu Leu Glu Glu Thr Leu Thr His Thr Ile Thr Lys 
        275                 280                 285             


Leu Asn Ala Glu Asn Asn Ala Thr Phe Tyr Phe Lys Ile Asp Asn Val 
    290                 295                 300                 


Lys Lys Ala Arg Val Gln Val Val Ala Gly Lys Lys Tyr Phe Ile Asp 
305                 310                 315                 320 


Phe Val Ala Arg Glu Thr Thr Cys Ser Lys Glu Ser Asn Glu Glu Leu 
                325                 330                 335     


Thr Glu Ser Cys Glu Thr Lys Lys Leu Gly Gln Ser Leu Asp Cys Asn 
            340                 345                 350         


Ala Glu Val Tyr Val Val Pro Trp Glu Lys Lys Ile Tyr Pro Thr Val 
        355                 360                 365             


Asn Cys Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly 
    370                 375                 380                 


Phe Ser Pro Phe Arg Ser Ser Arg Ile Gly Glu Ile Lys Glu Glu Thr 
385                 390                 395                 400 


Thr Ser His Leu Arg Ser Cys Glu Tyr Lys Gly Arg Pro Pro Lys Ala 
                405                 410                 415     


Gly Ala Glu Pro Ala Ser Glu Arg Glu Val Ser 
            420                 425         


<210>  5998
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KNSTRN__Homo_sapiens__NP_001136233

<400>  5998

Met Ala Ala Pro Glu Ala Pro Pro Leu Asp Arg Val Phe Arg Thr Thr 
1               5                   10                  15      


Trp Leu Ser Thr Glu Cys Asp Ser His Pro Leu Pro Pro Ser Tyr Arg 
            20                  25                  30          


Lys Phe Leu Phe Glu Thr Gln Ala Ala Asp Leu Ala Gly Gly Thr Thr 
        35                  40                  45              


Val Ala Ala Gly Asn Leu Leu Asn Glu Ser Glu Lys Asp Cys Gly Gln 
    50                  55                  60                  


Asp Arg Arg Ala Pro Gly Val Gln Pro Cys Arg Leu Val Thr Met Thr 
65                  70                  75                  80  


Ser Val Val Lys Thr Val Tyr Ser Leu Gln Pro Pro Ser Ala Leu Ser 
                85                  90                  95      


Gly Gly Gln Pro Ala Asp Thr Gln Thr Arg Ala Thr Ser Lys Ser Leu 
            100                 105                 110         


Leu Pro Val Arg Ser Lys Glu Val Asp Val Ser Lys Gln Leu His Ser 
        115                 120                 125             


Gly Gly Pro Glu Asn Asp Val Thr Lys Ile Thr Lys Leu Arg Arg Glu 
    130                 135                 140                 


Asn Gly Gln Met Lys Ala Thr Asp Thr Ala Thr Arg Arg Asn Val Arg 
145                 150                 155                 160 


Lys Gly Tyr Lys Pro Leu Ser Lys Gln Lys Ser Glu Glu Glu Leu Lys 
                165                 170                 175     


Asp Lys Asn Gln Leu Leu Glu Ala Val Asn Lys Gln Leu His Gln Lys 
            180                 185                 190         


Leu Thr Glu Thr Gln Gly Glu Leu Lys Asp Leu Thr Gln Lys Val Glu 
        195                 200                 205             


Leu Leu Glu Lys Phe Arg Asp Asn Cys Leu Ala Ile Leu Glu Ser Lys 
    210                 215                 220                 


Gly Leu Asp Pro Ala Leu Gly Ser Glu Thr Leu Ala Ser Arg Gln Glu 
225                 230                 235                 240 


Ser Thr Thr Asp His Met Asp Ser Met Leu Leu Leu Glu Thr Leu Gln 
                245                 250                 255     


Glu Glu Leu Lys Leu Phe Asn Glu Thr Ala Lys Lys Gln Met Glu Glu 
            260                 265                 270         


Leu Gln Ile Ala Trp Met Asn His Gly Ile Leu His Gln Met 
        275                 280                 285     


<210>  5999
<211>  2209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KNTC1__Homo_sapiens__NP_055523

<400>  5999

Met Trp Asn Asp Ile Glu Leu Leu Thr Asn Asp Asp Thr Gly Ser Gly 
1               5                   10                  15      


Tyr Leu Ser Val Gly Ser Arg Lys Glu His Gly Thr Ala Leu Tyr Gln 
            20                  25                  30          


Val Asp Leu Leu Val Lys Ile Ser Ser Glu Lys Ala Ser Leu Asn Pro 
        35                  40                  45              


Lys Ile Gln Ala Cys Ser Leu Ser Asp Gly Phe Ile Ile Val Ala Asp 
    50                  55                  60                  


Gln Ser Val Ile Leu Leu Asp Ser Ile Cys Arg Ser Leu Gln Leu His 
65                  70                  75                  80  


Leu Val Phe Asp Thr Glu Val Asp Val Val Gly Leu Cys Gln Glu Gly 
                85                  90                  95      


Lys Phe Leu Leu Val Gly Glu Arg Ser Gly Asn Leu His Leu Ile His 
            100                 105                 110         


Val Thr Ser Lys Gln Thr Leu Leu Thr Asn Ala Phe Val Gln Lys Ala 
        115                 120                 125             


Asn Asp Glu Asn Arg Arg Thr Tyr Gln Asn Leu Val Ile Glu Lys Asp 
    130                 135                 140                 


Gly Ser Asn Glu Gly Thr Tyr Tyr Met Leu Leu Leu Thr Tyr Ser Gly 
145                 150                 155                 160 


Phe Phe Cys Ile Thr Asn Leu Gln Leu Leu Lys Ile Gln Gln Ala Ile 
                165                 170                 175     


Glu Asn Val Asp Phe Ser Thr Ala Lys Lys Leu Gln Gly Gln Ile Lys 
            180                 185                 190         


Ser Ser Phe Ile Ser Thr Glu Asn Tyr His Thr Leu Gly Cys Leu Ser 
        195                 200                 205             


Leu Val Ala Gly Asp Leu Ala Ser Glu Val Pro Val Ile Ile Gly Gly 
    210                 215                 220                 


Thr Gly Asn Cys Ala Phe Ser Lys Trp Glu Pro Asp Ser Ser Lys Lys 
225                 230                 235                 240 


Gly Met Thr Val Lys Asn Leu Ile Asp Ala Glu Ile Ile Lys Gly Ala 
                245                 250                 255     


Lys Lys Phe Gln Leu Ile Asp Asn Leu Leu Phe Val Leu Asp Thr Asp 
            260                 265                 270         


Asn Val Leu Ser Leu Trp Asp Ile Tyr Thr Leu Thr Pro Val Trp Asn 
        275                 280                 285             


Trp Pro Ser Leu His Val Glu Glu Phe Leu Leu Thr Thr Glu Ala Asp 
    290                 295                 300                 


Ser Pro Ser Ser Val Thr Trp Gln Gly Ile Thr Asn Leu Lys Leu Ile 
305                 310                 315                 320 


Ala Leu Thr Ala Ser Ala Asn Lys Lys Met Lys Asn Leu Met Val Tyr 
                325                 330                 335     


Ser Leu Pro Thr Met Glu Ile Leu Tyr Ser Leu Glu Val Ser Ser Val 
            340                 345                 350         


Ser Ser Leu Val Gln Thr Gly Ile Ser Thr Asp Thr Ile Tyr Leu Leu 
        355                 360                 365             


Glu Gly Val Cys Lys Asn Asp Pro Lys Leu Ser Glu Asp Ser Val Ser 
    370                 375                 380                 


Val Leu Val Leu Arg Cys Leu Thr Glu Ala Leu Pro Glu Asn Arg Leu 
385                 390                 395                 400 


Ser Arg Leu Leu His Lys His Arg Phe Ala Glu Ala Glu Ser Phe Ala 
                405                 410                 415     


Ile Gln Phe Gly Leu Asp Val Glu Leu Val Tyr Lys Val Lys Ser Asn 
            420                 425                 430         


His Ile Leu Glu Lys Leu Ala Leu Ser Ser Val Asp Ala Ser Glu Gln 
        435                 440                 445             


Thr Glu Trp Gln Gln Leu Val Asp Asp Ala Lys Glu Asn Leu His Lys 
    450                 455                 460                 


Ile Gln Asp Asp Glu Phe Val Val Asn Tyr Cys Leu Lys Ala Gln Trp 
465                 470                 475                 480 


Ile Thr Tyr Glu Thr Thr Gln Glu Met Leu Asn Tyr Ala Lys Thr Arg 
                485                 490                 495     


Leu Leu Lys Lys Glu Asp Lys Thr Ala Leu Ile Tyr Ser Asp Gly Leu 
            500                 505                 510         


Lys Glu Val Leu Arg Ala His Ala Lys Leu Thr Thr Phe Tyr Gly Ala 
        515                 520                 525             


Phe Gly Pro Glu Lys Phe Ser Gly Ser Ser Trp Ile Glu Phe Leu Asn 
    530                 535                 540                 


Asn Glu Asp Asp Leu Lys Asp Ile Phe Leu Gln Leu Lys Glu Gly Asn 
545                 550                 555                 560 


Leu Val Cys Ala Gln Tyr Leu Trp Leu Arg His Arg Ala Asn Phe Glu 
                565                 570                 575     


Ser Arg Phe Asp Val Lys Met Leu Glu Ser Leu Leu Asn Ser Met Ser 
            580                 585                 590         


Ala Ser Val Ser Leu Gln Lys Leu Cys Pro Trp Phe Lys Asn Asp Val 
        595                 600                 605             


Ile Pro Phe Val Arg Arg Thr Val Pro Glu Gly Gln Ile Ile Leu Ala 
    610                 615                 620                 


Lys Trp Leu Glu Gln Ala Ala Arg Asn Leu Glu Leu Thr Asp Lys Ala 
625                 630                 635                 640 


Asn Trp Pro Glu Asn Gly Leu Gln Leu Ala Glu Ile Phe Phe Thr Ala 
                645                 650                 655     


Glu Lys Thr Asp Glu Leu Gly Leu Ala Ser Ser Trp His Trp Ile Ser 
            660                 665                 670         


Leu Lys Asp Tyr Gln Asn Thr Glu Glu Val Cys Gln Leu Arg Thr Leu 
        675                 680                 685             


Val Asn Asn Leu Arg Glu Leu Ile Thr Leu His Arg Lys Tyr Asn Cys 
    690                 695                 700                 


Lys Leu Ala Leu Ser Asp Phe Glu Lys Glu Asn Thr Thr Thr Ile Val 
705                 710                 715                 720 


Phe Arg Met Phe Asp Lys Val Leu Ala Pro Glu Leu Ile Pro Ser Ile 
                725                 730                 735     


Leu Glu Lys Phe Ile Arg Val Tyr Met Arg Glu His Asp Leu Gln Glu 
            740                 745                 750         


Glu Glu Leu Leu Leu Leu Tyr Ile Glu Asp Leu Leu Asn Arg Cys Ser 
        755                 760                 765             


Ser Lys Ser Thr Ser Leu Phe Glu Thr Ala Trp Glu Ala Lys Ala Met 
    770                 775                 780                 


Ala Val Ile Ala Cys Leu Ser Asp Thr Asp Leu Ile Phe Asp Ala Val 
785                 790                 795                 800 


Leu Lys Ile Met Tyr Ala Ala Val Val Pro Trp Ser Ala Ala Val Glu 
                805                 810                 815     


Gln Leu Val Lys Gln His Leu Glu Met Asp His Pro Lys Val Lys Leu 
            820                 825                 830         


Leu Gln Glu Ser Tyr Lys Leu Met Glu Met Lys Lys Leu Leu Arg Gly 
        835                 840                 845             


Tyr Gly Ile Arg Glu Val Asn Leu Leu Asn Lys Glu Ile Met Arg Val 
    850                 855                 860                 


Val Arg Tyr Ile Leu Lys Gln Asp Val Pro Ser Ser Leu Glu Asp Ala 
865                 870                 875                 880 


Leu Lys Val Ala Gln Ala Phe Met Leu Ser Asp Asp Glu Ile Tyr Ser 
                885                 890                 895     


Leu Arg Ile Ile Asp Leu Ile Asp Arg Glu Gln Gly Glu Asp Cys Leu 
            900                 905                 910         


Leu Leu Leu Lys Ser Leu Pro Pro Ala Glu Ala Glu Lys Thr Ala Glu 
        915                 920                 925             


Arg Val Ile Ile Trp Ala Arg Leu Ala Leu Gln Glu Glu Pro Asp His 
    930                 935                 940                 


Ser Lys Glu Gly Lys Ala Trp Arg Met Ser Val Ala Lys Thr Ser Val 
945                 950                 955                 960 


Asp Ile Leu Lys Ile Leu Cys Asp Ile Gln Lys Asp Asn Leu Gln Lys 
                965                 970                 975     


Lys Asp Glu Cys Glu Glu Met Leu Lys Leu Phe Lys Glu Val Ala Ser 
            980                 985                 990         


Leu Gln Glu Asn Phe Glu Val Phe  Leu Ser Phe Glu Asp  Tyr Ser Asn 
        995                 1000                 1005             


Ser Ser  Leu Val Ala Asp Leu  Arg Glu Gln His Ile  Lys Ala His 
    1010                 1015                 1020             


Glu Val  Ala Gln Ala Lys His  Lys Pro Gly Ser Thr  Pro Glu Pro 
    1025                 1030                 1035             


Ile Ala  Ala Glu Val Arg Ser  Pro Ser Met Glu Ser  Lys Leu His 
    1040                 1045                 1050             


Arg Gln  Ala Leu Ala Leu Gln  Met Ser Lys Gln Glu  Leu Glu Ala 
    1055                 1060                 1065             


Glu Leu  Thr Leu Arg Ala Leu  Lys Asp Gly Asn Ile  Lys Thr Ala 
    1070                 1075                 1080             


Leu Lys  Lys Cys Ser Asp Leu  Phe Lys Tyr His Cys  Asn Ala Asp 
    1085                 1090                 1095             


Thr Gly  Lys Leu Leu Phe Leu  Thr Cys Gln Lys Leu  Cys Gln Met 
    1100                 1105                 1110             


Leu Ala  Asp Asn Val Pro Val  Thr Val Pro Val Gly  Leu Asn Leu 
    1115                 1120                 1125             


Pro Ser  Met Ile His Asp Leu  Ala Ser Gln Ala Ala  Thr Ile Cys 
    1130                 1135                 1140             


Ser Pro  Asp Phe Leu Leu Asp  Ala Leu Glu Leu Cys  Lys His Thr 
    1145                 1150                 1155             


Leu Met  Ala Val Glu Leu Ser  Arg Gln Cys Gln Met  Asp Asp Cys 
    1160                 1165                 1170             


Gly Ile  Leu Met Lys Ala Ser  Phe Gly Thr His Lys  Asp Pro Tyr 
    1175                 1180                 1185             


Glu Glu  Trp Ser Tyr Ser Asp  Phe Phe Ser Glu Asp  Gly Ile Val 
    1190                 1195                 1200             


Leu Glu  Ser Gln Met Val Leu  Pro Val Ile Tyr Glu  Leu Ile Ser 
    1205                 1210                 1215             


Ser Leu  Val Pro Leu Ala Glu  Ser Lys Arg Tyr Pro  Leu Glu Ser 
    1220                 1225                 1230             


Thr Ser  Leu Pro Tyr Cys Ser  Leu Asn Glu Gly Asp  Gly Leu Val 
    1235                 1240                 1245             


Leu Pro  Val Ile Asn Ser Ile  Ser Ala Leu Leu Gln  Asn Leu Gln 
    1250                 1255                 1260             


Glu Ser  Ser Gln Trp Glu Leu  Ala Leu Arg Phe Val  Val Gly Ser 
    1265                 1270                 1275             


Phe Gly  Thr Cys Leu Gln His  Ser Val Ser Asn Phe  Met Asn Ala 
    1280                 1285                 1290             


Thr Leu  Ser Glu Lys Leu Phe  Gly Glu Thr Thr Leu  Val Lys Ser 
    1295                 1300                 1305             


Arg His  Val Val Met Glu Leu  Lys Glu Lys Ala Val  Ile Phe Ile 
    1310                 1315                 1320             


Arg Glu  Asn Ala Thr Thr Leu  Leu His Lys Val Phe  Asn Cys Arg 
    1325                 1330                 1335             


Leu Val  Asp Leu Asp Leu Ala  Leu Gly Tyr Cys Thr  Leu Leu Pro 
    1340                 1345                 1350             


Gln Lys  Asp Val Phe Glu Asn  Leu Trp Lys Leu Ile  Asp Lys Ala 
    1355                 1360                 1365             


Trp Gln  Asn Tyr Asp Lys Ile  Leu Ala Ile Ser Leu  Val Gly Ser 
    1370                 1375                 1380             


Glu Leu  Ala Ser Leu Tyr Gln  Glu Ile Glu Met Gly  Leu Lys Phe 
    1385                 1390                 1395             


Arg Glu  Leu Ser Thr Asp Ala  Gln Trp Gly Ile Arg  Leu Gly Lys 
    1400                 1405                 1410             


Leu Gly  Ile Ser Phe Gln Pro  Val Phe Arg Gln His  Phe Leu Thr 
    1415                 1420                 1425             


Lys Lys  Asp Leu Ile Lys Ala  Leu Val Glu Asn Ile  Asp Met Asp 
    1430                 1435                 1440             


Thr Ser  Leu Ile Leu Glu Tyr  Cys Ser Thr Phe Gln  Leu Asp Cys 
    1445                 1450                 1455             


Asp Ala  Val Leu Gln Leu Phe  Ile Glu Thr Leu Leu  His Asn Thr 
    1460                 1465                 1470             


Asn Ala  Gly Gln Gly Gln Gly  Asp Ala Ser Met Asp  Ser Ala Lys 
    1475                 1480                 1485             


Arg Arg  His Pro Lys Leu Leu  Ala Lys Ala Leu Glu  Met Val Pro 
    1490                 1495                 1500             


Leu Leu  Thr Ser Thr Lys Asp  Leu Val Ile Ser Leu  Ser Gly Ile 
    1505                 1510                 1515             


Leu His  Lys Leu Asp Pro Tyr  Asp Tyr Glu Met Ile  Glu Val Val 
    1520                 1525                 1530             


Leu Lys  Val Ile Glu Arg Ala  Asp Glu Lys Ile Thr  Asn Ile Asn 
    1535                 1540                 1545             


Ile Asn  Gln Ala Leu Ser Ile  Leu Lys His Leu Lys  Ser Tyr Arg 
    1550                 1555                 1560             


Arg Ile  Ser Pro Pro Val Asp  Leu Glu Tyr Gln Tyr  Met Leu Glu 
    1565                 1570                 1575             


His Val  Ile Thr Leu Pro Ser  Ala Ala Gln Thr Arg  Leu Pro Phe 
    1580                 1585                 1590             


His Leu  Ile Phe Phe Gly Thr  Ala Gln Asn Phe Trp  Lys Ile Leu 
    1595                 1600                 1605             


Ser Thr  Glu Leu Ser Glu Glu  Ser Phe Pro Thr Leu  Leu Leu Ile 
    1610                 1615                 1620             


Ser Lys  Leu Met Lys Phe Ser  Leu Asp Thr Leu Tyr  Val Ser Thr 
    1625                 1630                 1635             


Ala Lys  His Val Phe Glu Lys  Lys Leu Lys Pro Lys  Leu Leu Lys 
    1640                 1645                 1650             


Leu Thr  Gln Ala Lys Ser Ser  Thr Leu Ile Asn Lys  Glu Ile Thr 
    1655                 1660                 1665             


Lys Ile  Thr Gln Thr Ile Glu  Ser Cys Leu Leu Ser  Ile Val Asn 
    1670                 1675                 1680             


Pro Glu  Trp Ala Val Ala Ile  Ala Ile Ser Leu Ala  Gln Asp Ile 
    1685                 1690                 1695             


Pro Glu  Gly Ser Phe Lys Ile  Ser Ala Leu Lys Phe  Cys Leu Tyr 
    1700                 1705                 1710             


Leu Ala  Glu Arg Trp Leu Gln  Asn Ile Pro Ser Gln  Asp Glu Lys 
    1715                 1720                 1725             


Arg Glu  Lys Ala Glu Ala Leu  Leu Lys Lys Leu His  Ile Gln Tyr 
    1730                 1735                 1740             


Arg Arg  Ser Gly Thr Glu Ala  Val Leu Ile Ala His  Lys Leu Asn 
    1745                 1750                 1755             


Thr Glu  Glu Tyr Leu Arg Val  Ile Gly Lys Pro Ala  His Leu Ile 
    1760                 1765                 1770             


Val Ser  Leu Tyr Glu His Pro  Ser Ile Asn Gln Arg  Ile Gln Asn 
    1775                 1780                 1785             


Ser Ser  Gly Thr Asp Tyr Pro  Asp Ile His Ala Ala  Ala Lys Glu 
    1790                 1795                 1800             


Ile Ala  Glu Val Asn Glu Ile  Asn Leu Glu Lys Val  Trp Asp Met 
    1805                 1810                 1815             


Leu Leu  Glu Lys Trp Leu Cys  Pro Ser Thr Lys Pro  Gly Glu Lys 
    1820                 1825                 1830             


Pro Ser  Glu Leu Phe Glu Leu  Gln Glu Asp Glu Ala  Leu Arg Arg 
    1835                 1840                 1845             


Val Gln  Tyr Leu Leu Leu Ser  Arg Pro Ile Asp Tyr  Ser Ser Arg 
    1850                 1855                 1860             


Met Leu  Phe Val Phe Ala Thr  Ser Thr Thr Thr Thr  Leu Gly Met 
    1865                 1870                 1875             


His Gln  Leu Thr Phe Ala His  Arg Thr Arg Ala Leu  Gln Cys Leu 
    1880                 1885                 1890             


Phe Tyr  Leu Ala Asp Lys Glu  Thr Ile Glu Ser Leu  Phe Lys Lys 
    1895                 1900                 1905             


Pro Ile  Glu Glu Val Lys Ser  Tyr Leu Arg Cys Ile  Thr Phe Leu 
    1910                 1915                 1920             


Ala Ser  Phe Glu Thr Leu Asn  Ile Pro Ile Thr Tyr  Glu Leu Phe 
    1925                 1930                 1935             


Cys Ser  Ser Pro Lys Glu Gly  Met Ile Lys Gly Leu  Trp Lys Asn 
    1940                 1945                 1950             


His Ser  His Glu Ser Met Ala  Val Arg Leu Val Thr  Glu Leu Cys 
    1955                 1960                 1965             


Leu Glu  Tyr Lys Ile Tyr Asp  Leu Gln Leu Trp Asn  Gly Leu Leu 
    1970                 1975                 1980             


Gln Lys  Leu Leu Gly Phe Asn  Met Ile Pro Tyr Leu  Arg Lys Val 
    1985                 1990                 1995             


Leu Lys  Ala Ile Ser Ser Ile  His Ser Leu Trp Gln  Val Pro Tyr 
    2000                 2005                 2010             


Phe Ser  Lys Ala Trp Gln Arg  Val Ile Gln Ile Pro  Leu Leu Ser 
    2015                 2020                 2025             


Ala Ser  Cys Pro Leu Ser Pro  Asp Gln Leu Ser Asp  Cys Ser Glu 
    2030                 2035                 2040             


Ser Leu  Ile Ala Val Leu Glu  Cys Pro Val Ser Gly  Asp Leu Asp 
    2045                 2050                 2055             


Leu Ile  Gly Val Ala Arg Gln  Tyr Ile Gln Leu Glu  Leu Pro Ala 
    2060                 2065                 2070             


Phe Ala  Leu Ala Cys Leu Met  Leu Met Pro His Ser  Glu Lys Arg 
    2075                 2080                 2085             


His Gln  Gln Ile Lys Asn Phe  Leu Gly Ser Cys Asp  Pro Gln Val 
    2090                 2095                 2100             


Ile Leu  Lys Gln Leu Glu Glu  His Met Asn Thr Gly  Gln Leu Ala 
    2105                 2110                 2115             


Gly Phe  Ser His Gln Ile Arg  Ser Leu Ile Leu Asn  Asn Ile Ile 
    2120                 2125                 2130             


Asn Lys  Lys Glu Phe Gly Ile  Leu Ala Lys Thr Lys  Tyr Phe Gln 
    2135                 2140                 2145             


Met Leu  Lys Met His Ala Met  Asn Thr Asn Asn Ile  Thr Glu Leu 
    2150                 2155                 2160             


Val Asn  Tyr Leu Ala Asn Asp  Leu Ser Leu Asp Glu  Ala Ser Val 
    2165                 2170                 2175             


Leu Ile  Thr Glu Tyr Ser Lys  His Cys Gly Lys Pro  Val Pro Pro 
    2180                 2185                 2190             


Asp Thr  Ala Pro Cys Glu Ile  Leu Lys Met Phe Leu  Ser Gly Leu 
    2195                 2200                 2205             


Ser 
    


<210>  6000
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPNA1__Homo_sapiens__NP_002255

<400>  6000

Met Thr Thr Pro Gly Lys Glu Asn Phe Arg Leu Lys Ser Tyr Lys Asn 
1               5                   10                  15      


Lys Ser Leu Asn Pro Asp Glu Met Arg Arg Arg Arg Glu Glu Glu Gly 
            20                  25                  30          


Leu Gln Leu Arg Lys Gln Lys Arg Glu Glu Gln Leu Phe Lys Arg Arg 
        35                  40                  45              


Asn Val Ala Thr Ala Glu Glu Glu Thr Glu Glu Glu Val Met Ser Asp 
    50                  55                  60                  


Gly Gly Phe His Glu Ala Gln Ile Ser Asn Met Glu Met Ala Pro Gly 
65                  70                  75                  80  


Gly Val Ile Thr Ser Asp Met Ile Glu Met Ile Phe Ser Lys Ser Pro 
                85                  90                  95      


Glu Gln Gln Leu Ser Ala Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys 
            100                 105                 110         


Glu Pro Asn Pro Pro Ile Asp Glu Val Ile Ser Thr Pro Gly Val Val 
        115                 120                 125             


Ala Arg Phe Val Glu Phe Leu Lys Arg Lys Glu Asn Cys Thr Leu Gln 
    130                 135                 140                 


Phe Glu Ser Ala Trp Val Leu Thr Asn Ile Ala Ser Gly Asn Ser Leu 
145                 150                 155                 160 


Gln Thr Arg Ile Val Ile Gln Ala Gly Ala Val Pro Ile Phe Ile Glu 
                165                 170                 175     


Leu Leu Ser Ser Glu Phe Glu Asp Val Gln Glu Gln Ala Val Trp Ala 
            180                 185                 190         


Leu Gly Asn Ile Ala Gly Asp Ser Thr Met Cys Arg Asp Tyr Val Leu 
        195                 200                 205             


Asp Cys Asn Ile Leu Pro Pro Leu Leu Gln Leu Phe Ser Lys Gln Asn 
    210                 215                 220                 


Arg Leu Thr Met Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu Cys 
225                 230                 235                 240 


Arg Gly Lys Ser Pro Pro Pro Glu Phe Ala Lys Val Ser Pro Cys Leu 
                245                 250                 255     


Asn Val Leu Ser Trp Leu Leu Phe Val Ser Asp Thr Asp Val Leu Ala 
            260                 265                 270         


Asp Ala Cys Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Asp Lys 
        275                 280                 285             


Ile Gln Ala Val Ile Asp Ala Gly Val Cys Arg Arg Leu Val Glu Leu 
    290                 295                 300                 


Leu Met His Asn Asp Tyr Lys Val Val Ser Pro Ala Leu Arg Ala Val 
305                 310                 315                 320 


Gly Asn Ile Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu Asn 
                325                 330                 335     


Cys Ser Ala Leu Gln Ser Leu Leu His Leu Leu Ser Ser Pro Lys Glu 
            340                 345                 350         


Ser Ile Lys Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala Gly 
        355                 360                 365             


Asn Arg Ala Gln Ile Gln Thr Val Ile Asp Ala Asn Ile Phe Pro Ala 
    370                 375                 380                 


Leu Ile Ser Ile Leu Gln Thr Ala Glu Phe Arg Thr Arg Lys Glu Ala 
385                 390                 395                 400 


Ala Trp Ala Ile Thr Asn Ala Thr Ser Gly Gly Ser Ala Glu Gln Ile 
                405                 410                 415     


Lys Tyr Leu Val Glu Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu 
            420                 425                 430         


Thr Val Met Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu 
        435                 440                 445             


Asn Ile Leu Arg Leu Gly Glu Gln Glu Ala Lys Arg Asn Gly Thr Gly 
    450                 455                 460                 


Ile Asn Pro Tyr Cys Ala Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys 
465                 470                 475                 480 


Ile Glu Phe Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala 
                485                 490                 495     


Phe Asp Leu Ile Glu His Tyr Phe Gly Thr Glu Asp Glu Asp Ser Ser 
            500                 505                 510         


Ile Ala Pro Gln Val Asp Leu Asn Gln Gln Gln Tyr Ile Phe Gln Gln 
        515                 520                 525             


Cys Glu Ala Pro Met Glu Gly Phe Gln Leu 
    530                 535             


<210>  6001
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPNA2__Homo_sapiens__NP_001307540

<400>  6001

Met Ser Thr Asn Glu Asn Ala Asn Thr Pro Ala Ala Arg Leu His Arg 
1               5                   10                  15      


Phe Lys Asn Lys Gly Lys Asp Ser Thr Glu Met Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Val Asn Val Glu Leu Arg Lys Ala Lys Lys Asp Asp Gln Met Leu 
        35                  40                  45              


Lys Arg Arg Asn Val Ser Ser Phe Pro Asp Asp Ala Thr Ser Pro Leu 
    50                  55                  60                  


Gln Glu Asn Arg Asn Asn Gln Gly Thr Val Asn Trp Ser Val Asp Asp 
65                  70                  75                  80  


Ile Val Lys Gly Ile Asn Ser Ser Asn Val Glu Asn Gln Leu Gln Ala 
                85                  90                  95      


Thr Gln Ala Ala Arg Lys Leu Leu Ser Arg Glu Lys Gln Pro Pro Ile 
            100                 105                 110         


Asp Asn Ile Ile Arg Ala Gly Leu Ile Pro Lys Phe Val Ser Phe Leu 
        115                 120                 125             


Gly Arg Thr Asp Cys Ser Pro Ile Gln Phe Glu Ser Ala Trp Ala Leu 
    130                 135                 140                 


Thr Asn Ile Ala Ser Gly Thr Ser Glu Gln Thr Lys Ala Val Val Asp 
145                 150                 155                 160 


Gly Gly Ala Ile Pro Ala Phe Ile Ser Leu Leu Ala Ser Pro His Ala 
                165                 170                 175     


His Ile Ser Glu Gln Ala Val Trp Ala Leu Gly Asn Ile Ala Gly Asp 
            180                 185                 190         


Gly Ser Val Phe Arg Asp Leu Val Ile Lys Tyr Gly Ala Val Asp Pro 
        195                 200                 205             


Leu Leu Ala Leu Leu Ala Val Pro Asp Met Ser Ser Leu Ala Cys Gly 
    210                 215                 220                 


Tyr Leu Arg Asn Leu Thr Trp Thr Leu Ser Asn Leu Cys Arg Asn Lys 
225                 230                 235                 240 


Asn Pro Ala Pro Pro Ile Asp Ala Val Glu Gln Ile Leu Pro Thr Leu 
                245                 250                 255     


Val Arg Leu Leu His His Asp Asp Pro Glu Val Leu Ala Asp Thr Cys 
            260                 265                 270         


Trp Ala Ile Ser Tyr Leu Thr Asp Gly Pro Asn Glu Arg Ile Gly Met 
        275                 280                 285             


Val Val Lys Thr Gly Val Val Pro Gln Leu Val Lys Leu Leu Gly Ala 
    290                 295                 300                 


Ser Glu Leu Pro Ile Val Thr Pro Ala Leu Arg Ala Ile Gly Asn Ile 
305                 310                 315                 320 


Val Thr Gly Thr Asp Glu Gln Thr Gln Val Val Ile Asp Ala Gly Ala 
                325                 330                 335     


Leu Ala Val Phe Pro Ser Leu Leu Thr Asn Pro Lys Thr Asn Ile Gln 
            340                 345                 350         


Lys Glu Ala Thr Trp Thr Met Ser Asn Ile Thr Ala Gly Arg Gln Asp 
        355                 360                 365             


Gln Ile Gln Gln Val Val Asn His Gly Leu Val Pro Phe Leu Val Ser 
    370                 375                 380                 


Val Leu Ser Lys Ala Asp Phe Lys Thr Gln Lys Glu Ala Val Trp Ala 
385                 390                 395                 400 


Val Thr Asn Tyr Thr Ser Gly Gly Thr Val Glu Gln Ile Val Tyr Leu 
                405                 410                 415     


Val His Cys Gly Ile Ile Glu Pro Leu Met Asn Leu Leu Thr Ala Lys 
            420                 425                 430         


Asp Thr Lys Ile Ile Leu Val Ile Leu Asp Ala Ile Ser Asn Ile Phe 
        435                 440                 445             


Gln Ala Ala Glu Lys Leu Gly Glu Thr Glu Lys Leu Ser Ile Met Ile 
    450                 455                 460                 


Glu Glu Cys Gly Gly Leu Asp Lys Ile Glu Ala Leu Gln Asn His Glu 
465                 470                 475                 480 


Asn Glu Ser Val Tyr Lys Ala Ser Leu Ser Leu Ile Glu Lys Tyr Phe 
                485                 490                 495     


Ser Val Glu Glu Glu Glu Asp Gln Asn Val Val Pro Glu Thr Thr Ser 
            500                 505                 510         


Glu Gly Tyr Thr Phe Gln Val Gln Asp Gly Ala Pro Gly Thr Phe Asn 
        515                 520                 525             


Phe 
    


<210>  6002
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPNA3__Homo_sapiens__NP_002258

<400>  6002

Met Ala Glu Asn Pro Ser Leu Glu Asn His Arg Ile Lys Ser Phe Lys 
1               5                   10                  15      


Asn Lys Gly Arg Asp Val Glu Thr Met Arg Arg His Arg Asn Glu Val 
            20                  25                  30          


Thr Val Glu Leu Arg Lys Asn Lys Arg Asp Glu His Leu Leu Lys Lys 
        35                  40                  45              


Arg Asn Val Pro Gln Glu Glu Ser Leu Glu Asp Ser Asp Val Asp Ala 
    50                  55                  60                  


Asp Phe Lys Ala Gln Asn Val Thr Leu Glu Ala Ile Leu Gln Asn Ala 
65                  70                  75                  80  


Thr Ser Asp Asn Pro Val Val Gln Leu Ser Ala Val Gln Ala Ala Arg 
                85                  90                  95      


Lys Leu Leu Ser Ser Asp Arg Asn Pro Pro Ile Asp Asp Leu Ile Lys 
            100                 105                 110         


Ser Gly Ile Leu Pro Ile Leu Val Lys Cys Leu Glu Arg Asp Asp Asn 
        115                 120                 125             


Pro Ser Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser 
    130                 135                 140                 


Gly Thr Ser Ala Gln Thr Gln Ala Val Val Gln Ser Asn Ala Val Pro 
145                 150                 155                 160 


Leu Phe Leu Arg Leu Leu Arg Ser Pro His Gln Asn Val Cys Glu Gln 
                165                 170                 175     


Ala Val Trp Ala Leu Gly Asn Ile Ile Gly Asp Gly Pro Gln Cys Arg 
            180                 185                 190         


Asp Tyr Val Ile Ser Leu Gly Val Val Lys Pro Leu Leu Ser Phe Ile 
        195                 200                 205             


Ser Pro Ser Ile Pro Ile Thr Phe Leu Arg Asn Val Thr Trp Val Ile 
    210                 215                 220                 


Val Asn Leu Cys Arg Asn Lys Asp Pro Pro Pro Pro Met Glu Thr Val 
225                 230                 235                 240 


Gln Glu Ile Leu Pro Ala Leu Cys Val Leu Ile Tyr His Thr Asp Ile 
                245                 250                 255     


Asn Ile Leu Val Asp Thr Val Trp Ala Leu Ser Tyr Leu Thr Asp Gly 
            260                 265                 270         


Gly Asn Glu Gln Ile Gln Met Val Ile Asp Ser Gly Val Val Pro Phe 
        275                 280                 285             


Leu Val Pro Leu Leu Ser His Gln Glu Val Lys Val Gln Thr Ala Ala 
    290                 295                 300                 


Leu Arg Ala Val Gly Asn Ile Val Thr Gly Thr Asp Glu Gln Thr Gln 
305                 310                 315                 320 


Val Val Leu Asn Cys Asp Val Leu Ser His Phe Pro Asn Leu Leu Ser 
                325                 330                 335     


His Pro Lys Glu Lys Ile Asn Lys Glu Ala Val Trp Phe Leu Ser Asn 
            340                 345                 350         


Ile Thr Ala Gly Asn Gln Gln Gln Val Gln Ala Val Ile Asp Ala Gly 
        355                 360                 365             


Leu Ile Pro Met Ile Ile His Gln Leu Ala Lys Gly Asp Phe Gly Thr 
    370                 375                 380                 


Gln Lys Glu Ala Ala Trp Ala Ile Ser Asn Leu Thr Ile Ser Gly Arg 
385                 390                 395                 400 


Lys Asp Gln Val Glu Tyr Leu Val Gln Gln Asn Val Ile Pro Pro Phe 
                405                 410                 415     


Cys Asn Leu Leu Ser Val Lys Asp Ser Gln Val Val Gln Val Val Leu 
            420                 425                 430         


Asp Gly Leu Lys Asn Ile Leu Ile Met Ala Gly Asp Glu Ala Ser Thr 
        435                 440                 445             


Ile Ala Glu Ile Ile Glu Glu Cys Gly Gly Leu Glu Lys Ile Glu Val 
    450                 455                 460                 


Leu Gln Gln His Glu Asn Glu Asp Ile Tyr Lys Leu Ala Phe Glu Ile 
465                 470                 475                 480 


Ile Asp Gln Tyr Phe Ser Gly Asp Asp Ile Asp Glu Asp Pro Cys Leu 
                485                 490                 495     


Ile Pro Glu Ala Thr Gln Gly Gly Thr Tyr Asn Phe Asp Pro Thr Ala 
            500                 505                 510         


Asn Leu Gln Thr Lys Glu Phe Asn Phe 
        515                 520     


<210>  6003
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPNA4__Homo_sapiens__NP_002259

<400>  6003

Met Ala Asp Asn Glu Lys Leu Asp Asn Gln Arg Leu Lys Asn Phe Lys 
1               5                   10                  15      


Asn Lys Gly Arg Asp Leu Glu Thr Met Arg Arg Gln Arg Asn Glu Val 
            20                  25                  30          


Val Val Glu Leu Arg Lys Asn Lys Arg Asp Glu His Leu Leu Lys Arg 
        35                  40                  45              


Arg Asn Val Pro His Glu Asp Ile Cys Glu Asp Ser Asp Ile Asp Gly 
    50                  55                  60                  


Asp Tyr Arg Val Gln Asn Thr Ser Leu Glu Ala Ile Val Gln Asn Ala 
65                  70                  75                  80  


Ser Ser Asp Asn Gln Gly Ile Gln Leu Ser Ala Val Gln Ala Ala Arg 
                85                  90                  95      


Lys Leu Leu Ser Ser Asp Arg Asn Pro Pro Ile Asp Asp Leu Ile Lys 
            100                 105                 110         


Ser Gly Ile Leu Pro Ile Leu Val His Cys Leu Glu Arg Asp Asp Asn 
        115                 120                 125             


Pro Ser Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser 
    130                 135                 140                 


Gly Thr Ser Glu Gln Thr Gln Ala Val Val Gln Ser Asn Ala Val Pro 
145                 150                 155                 160 


Leu Phe Leu Arg Leu Leu His Ser Pro His Gln Asn Val Cys Glu Gln 
                165                 170                 175     


Ala Val Trp Ala Leu Gly Asn Ile Ile Gly Asp Gly Pro Gln Cys Arg 
            180                 185                 190         


Asp Tyr Val Ile Ser Leu Gly Val Val Lys Pro Leu Leu Ser Phe Ile 
        195                 200                 205             


Ser Pro Ser Ile Pro Ile Thr Phe Leu Arg Asn Val Thr Trp Val Met 
    210                 215                 220                 


Val Asn Leu Cys Arg His Lys Asp Pro Pro Pro Pro Met Glu Thr Ile 
225                 230                 235                 240 


Gln Glu Ile Leu Pro Ala Leu Cys Val Leu Ile His His Thr Asp Val 
                245                 250                 255     


Asn Ile Leu Val Asp Thr Val Trp Ala Leu Ser Tyr Leu Thr Asp Ala 
            260                 265                 270         


Gly Asn Glu Gln Ile Gln Met Val Ile Asp Ser Gly Ile Val Pro His 
        275                 280                 285             


Leu Val Pro Leu Leu Ser His Gln Glu Val Lys Val Gln Thr Ala Ala 
    290                 295                 300                 


Leu Arg Ala Val Gly Asn Ile Val Thr Gly Thr Asp Glu Gln Thr Gln 
305                 310                 315                 320 


Val Val Leu Asn Cys Asp Ala Leu Ser His Phe Pro Ala Leu Leu Thr 
                325                 330                 335     


His Pro Lys Glu Lys Ile Asn Lys Glu Ala Val Trp Phe Leu Ser Asn 
            340                 345                 350         


Ile Thr Ala Gly Asn Gln Gln Gln Val Gln Ala Val Ile Asp Ala Asn 
        355                 360                 365             


Leu Val Pro Met Ile Ile His Leu Leu Asp Lys Gly Asp Phe Gly Thr 
    370                 375                 380                 


Gln Lys Glu Ala Ala Trp Ala Ile Ser Asn Leu Thr Ile Ser Gly Arg 
385                 390                 395                 400 


Lys Asp Gln Val Ala Tyr Leu Ile Gln Gln Asn Val Ile Pro Pro Phe 
                405                 410                 415     


Cys Asn Leu Leu Thr Val Lys Asp Ala Gln Val Val Gln Val Val Leu 
            420                 425                 430         


Asp Gly Leu Ser Asn Ile Leu Lys Met Ala Glu Asp Glu Ala Glu Thr 
        435                 440                 445             


Ile Gly Asn Leu Ile Glu Glu Cys Gly Gly Leu Glu Lys Ile Glu Gln 
    450                 455                 460                 


Leu Gln Asn His Glu Asn Glu Asp Ile Tyr Lys Leu Ala Tyr Glu Ile 
465                 470                 475                 480 


Ile Asp Gln Phe Phe Ser Ser Asp Asp Ile Asp Glu Asp Pro Ser Leu 
                485                 490                 495     


Val Pro Glu Ala Ile Gln Gly Gly Thr Phe Gly Phe Asn Ser Ser Ala 
            500                 505                 510         


Asn Val Pro Thr Glu Gly Phe Gln Phe 
        515                 520     


<210>  6004
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPNA6__Homo_sapiens__XP_011539462

<400>  6004

Met Thr Met Ala Ser Pro Gly Lys Asp Asn Tyr Arg Met Lys Ser Tyr 
1               5                   10                  15      


Lys Asn Asn Ala Leu Asn Pro Glu Glu Met Arg Arg Arg Arg Glu Glu 
            20                  25                  30          


Glu Gly Ile Gln Leu Arg Lys Gln Lys Arg Glu Gln Gln Leu Phe Lys 
        35                  40                  45              


Arg Arg Asn Val Glu Leu Ile Asn Glu Glu Ala Ala Met Phe Asp Ser 
    50                  55                  60                  


Leu Leu Met Asp Ser Tyr Val Ser Ser Thr Thr Gly Glu Ser Val Ile 
65                  70                  75                  80  


Thr Arg Glu Met Val Glu Met Leu Phe Ser Asp Asp Ser Asp Leu Gln 
                85                  90                  95      


Leu Ala Thr Thr Gln Lys Phe Arg Lys Leu Leu Ser Lys Glu Pro Ser 
            100                 105                 110         


Pro Pro Ile Asp Glu Val Ile Asn Thr Pro Arg Val Val Asp Arg Phe 
        115                 120                 125             


Val Glu Phe Leu Lys Arg Asn Glu Asn Cys Thr Leu Gln Phe Glu Ala 
    130                 135                 140                 


Ala Trp Ala Leu Thr Asn Ile Ala Ser Gly Thr Ser Gln Gln Thr Lys 
145                 150                 155                 160 


Ile Val Ile Glu Ala Gly Ala Val Pro Ile Phe Ile Glu Leu Leu Asn 
                165                 170                 175     


Ser Asp Phe Glu Asp Val Gln Glu Gln Ala Val Trp Ala Leu Gly Asn 
            180                 185                 190         


Ile Ala Gly Asp Ser Ser Val Cys Arg Asp Tyr Val Leu Asn Cys Ser 
        195                 200                 205             


Ile Leu Asn Pro Leu Leu Thr Leu Leu Thr Lys Ser Thr Arg Leu Thr 
    210                 215                 220                 


Met Thr Arg Asn Ala Val Trp Ala Leu Ser Asn Leu Cys Arg Gly Lys 
225                 230                 235                 240 


Asn Pro Pro Pro Glu Phe Ala Lys Val Ser Pro Cys Leu Pro Val Leu 
                245                 250                 255     


Ser Arg Leu Leu Phe Ser Ser Asp Ser Asp Leu Leu Ala Asp Ala Cys 
            260                 265                 270         


Trp Ala Leu Ser Tyr Leu Ser Asp Gly Pro Asn Glu Lys Ile Gln Ala 
        275                 280                 285             


Val Ile Asp Ser Gly Val Cys Arg Arg Leu Val Glu Leu Leu Met His 
    290                 295                 300                 


Asn Asp Tyr Lys Val Ala Ser Pro Ala Leu Arg Ala Val Gly Asn Ile 
305                 310                 315                 320 


Val Thr Gly Asp Asp Ile Gln Thr Gln Val Ile Leu Asn Cys Ser Ala 
                325                 330                 335     


Leu Pro Cys Leu Leu His Leu Leu Ser Ser Pro Lys Glu Ser Ile Arg 
            340                 345                 350         


Lys Glu Ala Cys Trp Thr Ile Ser Asn Ile Thr Ala Gly Asn Arg Ala 
        355                 360                 365             


Gln Ile Gln Ala Val Ile Asp Ala Asn Ile Phe Pro Val Leu Ile Glu 
    370                 375                 380                 


Ile Leu Gln Lys Ala Glu Phe Arg Thr Arg Lys Glu Ala Ala Trp Ala 
385                 390                 395                 400 


Ile Thr Asn Ala Thr Ser Gly Gly Thr Pro Glu Gln Ile Arg Tyr Leu 
                405                 410                 415     


Val Ser Leu Gly Cys Ile Lys Pro Leu Cys Asp Leu Leu Thr Val Met 
            420                 425                 430         


Asp Ser Lys Ile Val Gln Val Ala Leu Asn Gly Leu Glu Asn Ile Leu 
        435                 440                 445             


Arg Leu Gly Glu Gln Glu Gly Lys Arg Ser Gly Ser Gly Val Asn Pro 
    450                 455                 460                 


Tyr Cys Gly Leu Ile Glu Glu Ala Tyr Gly Leu Asp Lys Ile Glu Phe 
465                 470                 475                 480 


Leu Gln Ser His Glu Asn Gln Glu Ile Tyr Gln Lys Ala Phe Asp Leu 
                485                 490                 495     


Ile Glu His Tyr Phe Gly Val Glu Asp Asp Asp Ser Ser Leu Ala Pro 
            500                 505                 510         


Gln Val Asp Glu Thr Gln Gln Gln Phe Ile Phe Gln Gln Pro Glu Ala 
        515                 520                 525             


Pro Met Glu Gly Phe Gln Leu 
    530                 535 


<210>  6005
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPNA7__Homo_sapiens__NP_001139187

<400>  6005

Met Pro Thr Leu Asp Ala Pro Glu Glu Arg Arg Arg Lys Phe Lys Tyr 
1               5                   10                  15      


Arg Gly Lys Asp Val Ser Leu Arg Arg Gln Gln Arg Met Ala Val Ser 
            20                  25                  30          


Leu Glu Leu Arg Lys Ala Lys Lys Asp Glu Gln Thr Leu Lys Arg Arg 
        35                  40                  45              


Asn Ile Thr Ser Phe Cys Pro Asp Thr Pro Ser Glu Lys Thr Ala Lys 
    50                  55                  60                  


Gly Val Ala Val Ser Leu Thr Leu Gly Glu Ile Ile Lys Gly Val Asn 
65                  70                  75                  80  


Ser Ser Asp Pro Val Leu Cys Phe Gln Ala Thr Gln Thr Ala Arg Lys 
                85                  90                  95      


Met Leu Ser Gln Glu Lys Asn Pro Pro Leu Lys Leu Val Ile Glu Ala 
            100                 105                 110         


Gly Leu Ile Pro Arg Met Val Glu Phe Leu Lys Ser Ser Leu Tyr Pro 
        115                 120                 125             


Cys Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser Gly 
    130                 135                 140                 


Thr Ser Glu Gln Thr Arg Ala Val Val Glu Gly Gly Ala Ile Gln Pro 
145                 150                 155                 160 


Leu Ile Glu Leu Leu Ser Ser Ser Asn Val Ala Val Cys Glu Gln Ala 
                165                 170                 175     


Val Trp Ala Leu Gly Asn Ile Ala Gly Asp Gly Pro Glu Phe Arg Asp 
            180                 185                 190         


Asn Val Ile Thr Ser Asn Ala Ile Pro His Leu Leu Ala Leu Ile Ser 
        195                 200                 205             


Pro Thr Leu Pro Ile Thr Phe Leu Arg Asn Ile Thr Trp Thr Leu Ser 
    210                 215                 220                 


Asn Leu Cys Arg Asn Lys Asn Pro Tyr Pro Cys Asp Thr Ala Val Lys 
225                 230                 235                 240 


Gln Ile Leu Pro Ala Leu Leu His Leu Leu Gln His Gln Asp Ser Glu 
                245                 250                 255     


Val Leu Ser Asp Ala Cys Trp Ala Leu Ser Tyr Leu Thr Asp Gly Ser 
            260                 265                 270         


Asn Lys Arg Ile Gly Gln Val Val Asn Thr Gly Val Leu Pro Arg Leu 
        275                 280                 285             


Val Val Leu Met Thr Ser Ser Glu Leu Asn Val Leu Thr Pro Ser Leu 
    290                 295                 300                 


Arg Thr Val Gly Asn Ile Val Thr Gly Thr Asp Glu Gln Thr Gln Met 
305                 310                 315                 320 


Ala Ile Asp Ala Gly Met Leu Asn Val Leu Pro Gln Leu Leu Gln His 
                325                 330                 335     


Asn Lys Pro Ser Ile Gln Lys Glu Ala Ala Trp Ala Leu Ser Asn Val 
            340                 345                 350         


Ala Ala Gly Pro Cys His His Ile Gln Gln Leu Leu Ala Tyr Asp Val 
        355                 360                 365             


Leu Pro Pro Leu Val Ala Leu Leu Lys Asn Gly Glu Phe Lys Val Gln 
    370                 375                 380                 


Lys Glu Ala Val Trp Met Val Ala Asn Phe Ala Thr Gly Ala Thr Met 
385                 390                 395                 400 


Asp Gln Leu Ile Gln Leu Val His Ser Gly Val Leu Glu Pro Leu Val 
                405                 410                 415     


Asn Leu Leu Thr Ala Pro Asp Val Lys Ile Val Leu Ile Ile Leu Asp 
            420                 425                 430         


Val Ile Ser Cys Ile Leu Gln Ala Ala Glu Lys Arg Ser Glu Lys Glu 
        435                 440                 445             


Asn Leu Cys Leu Leu Ile Glu Glu Leu Gly Gly Ile Asp Arg Ile Glu 
    450                 455                 460                 


Ala Leu Gln Leu His Glu Asn Arg Gln Ile Gly Gln Ser Ala Leu Asn 
465                 470                 475                 480 


Ile Ile Glu Lys His Phe Gly Glu Glu Glu Asp Glu Ser Gln Thr Leu 
                485                 490                 495     


Leu Ser Gln Val Ile Asp Gln Asp Tyr Glu Phe Ile Asp Tyr Glu Cys 
            500                 505                 510         


Leu Ala Lys Lys 
        515     


<210>  6006
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPNB1__Homo_sapiens__NP_001263382

<400>  6006

Met Lys Glu Ser Thr Leu Glu Ala Ile Gly Tyr Ile Cys Gln Asp Ile 
1               5                   10                  15      


Asp Pro Glu Gln Leu Gln Asp Lys Ser Asn Glu Ile Leu Thr Ala Ile 
            20                  25                  30          


Ile Gln Gly Met Arg Lys Glu Glu Pro Ser Asn Asn Val Lys Leu Ala 
        35                  40                  45              


Ala Thr Asn Ala Leu Leu Asn Ser Leu Glu Phe Thr Lys Ala Asn Phe 
    50                  55                  60                  


Asp Lys Glu Ser Glu Arg His Phe Ile Met Gln Val Val Cys Glu Ala 
65                  70                  75                  80  


Thr Gln Cys Pro Asp Thr Arg Val Arg Val Ala Ala Leu Gln Asn Leu 
                85                  90                  95      


Val Lys Ile Met Ser Leu Tyr Tyr Gln Tyr Met Glu Thr Tyr Met Gly 
            100                 105                 110         


Pro Ala Leu Phe Ala Ile Thr Ile Glu Ala Met Lys Ser Asp Ile Asp 
        115                 120                 125             


Glu Val Ala Leu Gln Gly Ile Glu Phe Trp Ser Asn Val Cys Asp Glu 
    130                 135                 140                 


Glu Met Asp Leu Ala Ile Glu Ala Ser Glu Ala Ala Glu Gln Gly Arg 
145                 150                 155                 160 


Pro Pro Glu His Thr Ser Lys Phe Tyr Ala Lys Gly Ala Leu Gln Tyr 
                165                 170                 175     


Leu Val Pro Ile Leu Thr Gln Thr Leu Thr Lys Gln Asp Glu Asn Asp 
            180                 185                 190         


Asp Asp Asp Asp Trp Asn Pro Cys Lys Ala Ala Gly Val Cys Leu Met 
        195                 200                 205             


Leu Leu Ala Thr Cys Cys Glu Asp Asp Ile Val Pro His Val Leu Pro 
    210                 215                 220                 


Phe Ile Lys Glu His Ile Lys Asn Pro Asp Trp Arg Tyr Arg Asp Ala 
225                 230                 235                 240 


Ala Val Met Ala Phe Gly Cys Ile Leu Glu Gly Pro Glu Pro Ser Gln 
                245                 250                 255     


Leu Lys Pro Leu Val Ile Gln Ala Met Pro Thr Leu Ile Glu Leu Met 
            260                 265                 270         


Lys Asp Pro Ser Val Val Val Arg Asp Thr Ala Ala Trp Thr Val Gly 
        275                 280                 285             


Arg Ile Cys Glu Leu Leu Pro Glu Ala Ala Ile Asn Asp Val Tyr Leu 
    290                 295                 300                 


Ala Pro Leu Leu Gln Cys Leu Ile Glu Gly Leu Ser Ala Glu Pro Arg 
305                 310                 315                 320 


Val Ala Ser Asn Val Cys Trp Ala Phe Ser Ser Leu Ala Glu Ala Ala 
                325                 330                 335     


Tyr Glu Ala Ala Asp Val Ala Asp Asp Gln Glu Glu Pro Ala Thr Tyr 
            340                 345                 350         


Cys Leu Ser Ser Ser Phe Glu Leu Ile Val Gln Lys Leu Leu Glu Thr 
        355                 360                 365             


Thr Asp Arg Pro Asp Gly His Gln Asn Asn Leu Arg Ser Ser Ala Tyr 
    370                 375                 380                 


Glu Ser Leu Met Glu Ile Val Lys Asn Ser Ala Lys Asp Cys Tyr Pro 
385                 390                 395                 400 


Ala Val Gln Lys Thr Thr Leu Val Ile Met Glu Arg Leu Gln Gln Val 
                405                 410                 415     


Leu Gln Met Glu Ser His Ile Gln Ser Thr Ser Asp Arg Ile Gln Phe 
            420                 425                 430         


Asn Asp Leu Gln Ser Leu Leu Cys Ala Thr Leu Gln Asn Val Leu Arg 
        435                 440                 445             


Lys Val Gln His Gln Asp Ala Leu Gln Ile Ser Asp Val Val Met Ala 
    450                 455                 460                 


Ser Leu Leu Arg Met Phe Gln Ser Thr Ala Gly Ser Gly Gly Val Gln 
465                 470                 475                 480 


Glu Asp Ala Leu Met Ala Val Ser Thr Leu Val Glu Val Leu Gly Gly 
                485                 490                 495     


Glu Phe Leu Lys Tyr Met Glu Ala Phe Lys Pro Phe Leu Gly Ile Gly 
            500                 505                 510         


Leu Lys Asn Tyr Ala Glu Tyr Gln Val Cys Leu Ala Ala Val Gly Leu 
        515                 520                 525             


Val Gly Asp Leu Cys Arg Ala Leu Gln Ser Asn Ile Ile Pro Phe Cys 
    530                 535                 540                 


Asp Glu Val Met Gln Leu Leu Leu Glu Asn Leu Gly Asn Glu Asn Val 
545                 550                 555                 560 


His Arg Ser Val Lys Pro Gln Ile Leu Ser Val Phe Gly Asp Ile Ala 
                565                 570                 575     


Leu Ala Ile Gly Gly Glu Phe Lys Lys Tyr Leu Glu Val Val Leu Asn 
            580                 585                 590         


Thr Leu Gln Gln Ala Ser Gln Ala Gln Val Asp Lys Ser Asp Tyr Asp 
        595                 600                 605             


Met Val Asp Tyr Leu Asn Glu Leu Arg Glu Ser Cys Leu Glu Ala Tyr 
    610                 615                 620                 


Thr Gly Ile Val Gln Gly Leu Lys Gly Asp Gln Glu Asn Val His Pro 
625                 630                 635                 640 


Asp Val Met Leu Val Gln Pro Arg Val Glu Phe Ile Leu Ser Phe Ile 
                645                 650                 655     


Asp His Ile Ala Gly Asp Glu Asp His Thr Asp Gly Val Val Ala Cys 
            660                 665                 670         


Ala Ala Gly Leu Ile Gly Asp Leu Cys Thr Ala Phe Gly Lys Asp Val 
        675                 680                 685             


Leu Lys Leu Val Glu Ala Arg Pro Met Ile His Glu Leu Leu Thr Glu 
    690                 695                 700                 


Gly Arg Arg Ser Lys Thr Asn Lys Ala Lys Thr Leu Ala Thr Trp Ala 
705                 710                 715                 720 


Thr Lys Glu Leu Arg Lys Leu Lys Asn Gln Ala 
                725                 730     


<210>  6007
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPRP__Homo_sapiens__NP_001020402

<400>  6007

Met Cys Asp Gln Gln Gln Ile Gln Cys Arg Leu Pro Leu Gln Gln Cys 
1               5                   10                  15      


Cys Val Lys Gly Pro Ser Phe Cys Ser Ser Gln Ser Pro Phe Ala Gln 
            20                  25                  30          


Ser Gln Val Val Val Gln Ala Pro Cys Glu Met Gln Ile Val Asp Cys 
        35                  40                  45              


Pro Ala Ser Cys Pro Val Gln Val Cys Gln Val Ser Asp Gln Ala Pro 
    50                  55                  60                  


Cys Gln Ser Gln Thr Thr Gln Val Lys Cys Gln Ser Lys Thr Lys Gln 
65                  70                  75                  80  


Val Lys Gly Gln Ala Gln Cys Gln Ser Lys Thr Thr Gln Val Lys Gly 
                85                  90                  95      


Gln Ala Ala Ser Gln Ser Gln Thr Ser Ser Val Gln Ser Gln Ala Pro 
            100                 105                 110         


Cys Gln Ser Glu Val Ser Tyr Val Gln Cys Glu Ala Ser Gln Pro Val 
        115                 120                 125             


Gln Thr Cys Phe Val Glu Cys Ala Pro Val Cys Tyr Thr Glu Thr Cys 
    130                 135                 140                 


Tyr Val Glu Cys Pro Val Gln Asn Tyr Val Pro Cys Pro Ala Pro Gln 
145                 150                 155                 160 


Pro Val Gln Met Tyr Arg Gly Arg Pro Ala Val Cys Gln Pro Gln Gly 
                165                 170                 175     


Arg Phe Ser Thr Gln Cys Gln Tyr Gln Gly Ser Tyr Ser Ser Cys Gly 
            180                 185                 190         


Pro Gln Phe Gln Ser Arg Ala Thr Cys Asn Asn Tyr Thr Pro Gln Phe 
        195                 200                 205             


Gln Leu Arg Pro Ser Tyr Ser Ser Cys Phe Pro Gln Tyr Arg Ser Arg 
    210                 215                 220                 


Thr Ser Phe Ser Pro Cys Val Pro Gln Cys Gln Thr Gln Gly Ser Tyr 
225                 230                 235                 240 


Gly Ser Phe Thr Glu Gln His Arg Ser Arg Ser Thr Ser Arg Cys Leu 
                245                 250                 255     


Pro Pro Pro Arg Arg Leu Gln Leu Phe Pro Arg Ser Cys Ser Pro Pro 
            260                 265                 270         


Arg Arg Phe Glu Pro Cys Ser Ser Ser Tyr Leu Pro Leu Arg Pro Ser 
        275                 280                 285             


Glu Gly Phe Pro Asn Tyr Cys Thr Pro Pro Arg Arg Ser Glu Pro Ile 
    290                 295                 300                 


Tyr Asn Ser Arg Cys Pro Arg Arg Pro Ile Ser Ser Cys Ser Gln Arg 
305                 310                 315                 320 


Arg Gly Pro Lys Cys Arg Ile Glu Ile Ser Ser Pro Cys Cys Pro Arg 
                325                 330                 335     


Gln Val Pro Pro Gln Arg Cys Pro Val Glu Ile Pro Pro Ile Arg Arg 
            340                 345                 350         


Arg Ser Gln Ser Cys Gly Pro Gln Pro Ser Trp Gly Ala Ser Cys Pro 
        355                 360                 365             


Glu Leu Arg Pro His Val Glu Pro Arg Pro Leu Pro Ser Phe Cys Pro 
    370                 375                 380                 


Pro Arg Arg Leu Asp Gln Cys Pro Glu Ser Pro Leu Gln Arg Cys Pro 
385                 390                 395                 400 


Pro Pro Ala Pro Arg Pro Arg Leu Arg Pro Glu Pro Cys Ile Ser Leu 
                405                 410                 415     


Glu Pro Arg Pro Arg Pro Leu Pro Arg Gln Leu Ser Glu Pro Cys Leu 
            420                 425                 430         


Tyr Pro Glu Pro Leu Pro Ala Leu Arg Pro Thr Pro Arg Pro Val Pro 
        435                 440                 445             


Leu Pro Arg Pro Gly Gln Cys Glu Ile Pro Glu Pro Arg Pro Cys Leu 
    450                 455                 460                 


Gln Pro Cys Glu His Pro Glu Pro Cys Pro Arg Pro Glu Pro Ile Pro 
465                 470                 475                 480 


Leu Pro Ala Pro Cys Pro Ser Pro Glu Pro Cys Arg Glu Thr Trp Arg 
                485                 490                 495     


Ser Pro Ser Pro Cys Trp Gly Pro Asn Pro Val Pro Tyr Pro Gly Asp 
            500                 505                 510         


Leu Gly Cys His Glu Ser Ser Pro His Arg Leu Asp Thr Glu Ala Pro 
        515                 520                 525             


Tyr Cys Gly Pro Ser Ser Tyr Asn Gln Gly Gln Glu Ser Gly Ala Gly 
    530                 535                 540                 


Cys Gly Pro Gly Asp Val Phe Pro Glu Arg Arg Gly Gln Asp Gly His 
545                 550                 555                 560 


Gly Asp Gln Gly Asn Ala Phe Ala Gly Val Lys Gly Glu Ala Lys Ser 
                565                 570                 575     


Ala Tyr Phe 
            


<210>  6008
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KPTN__Homo_sapiens__NP_001278225

<400>  6008

Met Met Gly Glu Ala Ala Val Ala Ala Gly Pro Cys Pro Leu Arg Glu 
1               5                   10                  15      


Asp Ser Phe Thr Arg Phe Ser Ser Gln Ser Asn Val Tyr Gly Leu Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Arg Gly Glu Leu Leu Ala Ala Thr Leu Lys Gly 
        35                  40                  45              


Lys Val Leu Gly Phe Arg Tyr Gln Asp Leu Arg Gln Lys Ile Arg Pro 
    50                  55                  60                  


Val Ala Lys Glu Leu Gln Phe Asn Tyr Ile Pro Glu Ser Cys Leu Asn 
65                  70                  75                  80  


Leu Glu Leu Gln Phe Thr Pro Phe Gln Leu Cys His Ala Glu Val Gln 
                85                  90                  95      


Val Gly Asp Gln Leu Glu Thr Val Phe Leu Leu Ser Gly Asn Asp Pro 
            100                 105                 110         


Ala Ile His Leu Tyr Lys Glu Asn Glu Gly Leu His Gln Phe Glu Glu 
        115                 120                 125             


Gln Pro Val Glu Asn Leu Phe Pro Glu Leu Thr Asn Leu Thr Ser Ser 
    130                 135                 140                 


Val Leu Trp Leu Asp Val His Asn Phe Pro Gly Thr Ser Arg Arg Leu 
145                 150                 155                 160 


Ser Ala Leu Gly Cys Gln Ser Gly Tyr Val Arg Val Ala His Val Asp 
                165                 170                 175     


Gln Arg Ser Arg Glu Val Leu Gln Met Trp Ser Val Leu Gln Asp Gly 
            180                 185                 190         


Pro Ile Ser Arg Val Ile Val Phe Ser Leu Ser Ala Ala Lys Glu Thr 
        195                 200                 205             


Lys Asp Arg Pro Leu Gln Asp Glu Tyr Ser Val Leu Val Ala Ser Met 
    210                 215                 220                 


Leu Glu Pro Ala Val Val Tyr Arg Asp Leu Leu Asn Arg Gly Leu Glu 
225                 230                 235                 240 


Asp Gln Leu Leu Leu Pro Gly Ser Asp Gln Phe Asp Ser Val Leu Cys 
                245                 250                 255     


Ser Leu Val Thr Asp Val Asp Leu Asp Gly Arg Pro Glu Val Leu Val 
            260                 265                 270         


Ala Thr Tyr Gly Gln Glu Leu Leu Cys Tyr Lys Tyr Arg Gly Pro Glu 
        275                 280                 285             


Ser Gly Leu Pro Glu Ala Gln His Gly Phe His Leu Leu Trp Gln Arg 
    290                 295                 300                 


Ser Phe Ser Ser Pro Leu Leu Ala Met Ala His Val Asp Leu Thr Gly 
305                 310                 315                 320 


Asp Gly Leu Gln Glu Leu Ala Val Val Ser Leu Lys Gly Val His Ile 
                325                 330                 335     


Leu Gln His Ser Leu Ile Gln Ala Ser Glu Leu Val Leu Thr Arg Leu 
            340                 345                 350         


Arg His Gln Val Glu Gln Arg Arg Arg Arg Leu Gln Gly Leu Glu Asp 
        355                 360                 365             


Gly Ala Gly Ala Gly Pro Ala Glu Asn Ala Ala Ser 
    370                 375                 380 


<210>  6009
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS__Homo_sapiens__NP_004976

<400>  6009

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  6010
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRBOX4__Homo_sapiens__NP_001123370

<400>  6010

Met Ala Met Ser Gln Glu Ser Leu Thr Phe Lys Asp Val Phe Val Asp 
1               5                   10                  15      


Phe Thr Leu Glu Glu Trp Gln Gln Leu Asp Ser Ala Gln Lys Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly 
        35                  40                  45              


Tyr Leu Val Ala Lys Pro Asp Val Ile Phe Arg Leu Gly Pro Gly Glu 
    50                  55                  60                  


Glu Ser Trp Met Ala Asp Gly Gly Thr Pro Val Arg Thr Cys Ala Gly 
65                  70                  75                  80  


Glu Asp Arg Pro Glu Val Trp Gln Val Asp Glu Gln Ile Asp His Tyr 
                85                  90                  95      


Lys Glu Ser Gln Asp Lys Leu Pro Trp Gln Ala Ala Phe Ile Gly Lys 
            100                 105                 110         


Glu Thr Leu Lys Asp Glu Ser Gly Gln Glu Ser Arg Thr Cys Arg Lys 
        115                 120                 125             


Ser Ile Tyr Leu Ser Thr Glu Phe Asp Ser Val Arg Gln Arg Leu Pro 
    130                 135                 140                 


Lys Tyr Tyr Ser Trp Glu Lys Ala Phe Lys Thr Ser Phe Lys Leu Ser 
145                 150                 155                 160 


Trp Ser Lys Trp Lys Leu Cys Lys Lys Glu Arg 
                165                 170     


<210>  6011
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KREMEN1__Homo_sapiens__NP_001034659

<400>  6011

Met Ala Pro Pro Ala Ala Arg Leu Ala Leu Leu Ser Ala Ala Ala Leu 
1               5                   10                  15      


Thr Leu Ala Ala Arg Pro Ala Pro Ser Pro Gly Leu Gly Pro Gly Pro 
            20                  25                  30          


Glu Cys Phe Thr Ala Asn Gly Ala Asp Tyr Arg Gly Thr Gln Asn Trp 
        35                  40                  45              


Thr Ala Leu Gln Gly Gly Lys Pro Cys Leu Phe Trp Asn Glu Thr Phe 
    50                  55                  60                  


Gln His Pro Tyr Asn Thr Leu Lys Tyr Pro Asn Gly Glu Gly Gly Leu 
65                  70                  75                  80  


Gly Glu His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Ser Pro Trp 
                85                  90                  95      


Cys Tyr Val Ala Glu His Glu Asp Gly Val Tyr Trp Lys Tyr Cys Glu 
            100                 105                 110         


Ile Pro Ala Cys Gln Met Pro Gly Asn Leu Gly Cys Tyr Lys Asp His 
        115                 120                 125             


Gly Asn Pro Pro Pro Leu Thr Gly Thr Ser Lys Thr Ser Asn Lys Leu 
    130                 135                 140                 


Thr Ile Gln Thr Cys Ile Ser Phe Cys Arg Ser Gln Arg Phe Lys Phe 
145                 150                 155                 160 


Ala Gly Met Glu Ser Gly Tyr Ala Cys Phe Cys Gly Asn Asn Pro Asp 
                165                 170                 175     


Tyr Trp Lys Tyr Gly Glu Ala Ala Ser Thr Glu Cys Asn Ser Val Cys 
            180                 185                 190         


Phe Gly Asp His Thr Gln Pro Cys Gly Gly Asp Gly Arg Ile Ile Leu 
        195                 200                 205             


Phe Asp Thr Leu Val Gly Ala Cys Gly Gly Asn Tyr Ser Ala Met Ser 
    210                 215                 220                 


Ser Val Val Tyr Ser Pro Asp Phe Pro Asp Thr Tyr Ala Thr Gly Arg 
225                 230                 235                 240 


Val Cys Tyr Trp Thr Ile Arg Val Pro Gly Ala Ser His Ile His Phe 
                245                 250                 255     


Ser Phe Pro Leu Phe Asp Ile Arg Asp Ser Ala Asp Met Val Glu Leu 
            260                 265                 270         


Leu Asp Gly Tyr Thr His Arg Val Leu Ala Arg Phe His Gly Arg Ser 
        275                 280                 285             


Arg Pro Pro Leu Ser Phe Asn Val Ser Leu Asp Phe Val Ile Leu Tyr 
    290                 295                 300                 


Phe Phe Ser Asp Arg Ile Asn Gln Ala Gln Gly Phe Ala Val Leu Tyr 
305                 310                 315                 320 


Gln Ala Val Lys Glu Glu Leu Pro Gln Glu Arg Pro Ala Val Asn Gln 
                325                 330                 335     


Thr Val Ala Glu Val Ile Thr Glu Gln Ala Asn Leu Ser Val Ser Ala 
            340                 345                 350         


Ala Arg Ser Ser Lys Val Leu Tyr Val Ile Thr Thr Ser Pro Ser His 
        355                 360                 365             


Pro Pro Gln Thr Val Pro Gly Trp Thr Val Tyr Gly Leu Ala Thr Leu 
    370                 375                 380                 


Leu Ile Leu Thr Val Thr Ala Ile Val Ala Lys Ile Leu Leu His Val 
385                 390                 395                 400 


Thr Phe Lys Ser His Arg Val Pro Ala Ser Gly Asp Leu Arg Asp Cys 
                405                 410                 415     


His Gln Pro Gly Thr Ser Gly Glu Ile Trp Ser Ile Phe Tyr Lys Pro 
            420                 425                 430         


Ser Thr Ser Ile Ser Ile Phe Lys Lys Lys Leu Lys Gly Gln Ser Gln 
        435                 440                 445             


Gln Asp Asp Arg Asn Pro Leu Val Ser Asp 
    450                 455             


<210>  6012
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRIT1__Homo_sapiens__NP_001013424

<400>  6012

Met Gly Asn Pro Glu Asn Ile Glu Asp Ala Tyr Val Ala Val Ile Arg 
1               5                   10                  15      


Pro Lys Asn Thr Ala Ser Leu Asn Ser Arg Glu Tyr Arg Ala Lys Ser 
            20                  25                  30          


Tyr Glu Ile Leu Leu His Glu Val Pro Ile Glu Gly Gln Lys Lys Lys 
        35                  40                  45              


Arg Lys Lys Val Leu Leu Glu Thr Lys Leu Gln Gly Asn Ser Glu Ile 
    50                  55                  60                  


Thr Gln Gly Ile Leu Asp Tyr Val Val Glu Thr Thr Lys Pro Ile Ser 
65                  70                  75                  80  


Pro Ala Asn Gln Gly Ile Arg Gly Lys Arg Val Val Leu Met Lys Lys 
                85                  90                  95      


Phe Pro Leu Asp Gly Glu Lys Met Gly Arg Glu Ala Ser Leu Phe Ile 
            100                 105                 110         


Val Pro Ser Val Val Lys Asp Asn Thr Lys Tyr Thr Tyr Thr Pro Gly 
        115                 120                 125             


Cys Pro Ile Phe Tyr Cys Leu Gln Asp Ile Met Arg Val Cys Ser Glu 
    130                 135                 140                 


Ser Ser Thr His Phe Ala Thr Leu Thr Ala Arg Met Leu Ile Ala Leu 
145                 150                 155                 160 


Asp Lys Trp Leu Asp Glu Arg His Ala Gln Ser His Phe Ile Pro Ala 
                165                 170                 175     


Leu Phe Arg Pro Ser Pro Leu Glu Arg Ile Lys Thr Asn Val Ile Asn 
            180                 185                 190         


Pro Ala Tyr Ala Thr Glu Ser Gly Gln Thr Glu Asn Ser Leu His Met 
        195                 200                 205             


Gly Tyr Ser Ala Leu Glu Ile Lys Ser Lys Met Leu Ala Leu Glu Lys 
    210                 215                 220                 


Ala Asp Thr Cys Ile Tyr Asn Pro Leu Phe Gly Ser Asp Leu Gln Tyr 
225                 230                 235                 240 


Thr Asn Arg Val Asp Lys Val Val Ile Asn Pro Tyr Phe Gly Leu Gly 
                245                 250                 255     


Ala Pro Asp Tyr Ser Lys Ile Gln Ile Pro Lys Gln Glu Lys Trp Gln 
            260                 265                 270         


Arg Ser Met Ser Ser Val Thr Glu Asp Lys Tyr Gly Lys Val Glu Ala 
        275                 280                 285             


Thr Arg Ile Leu Leu Glu Lys Gly Lys Cys Asn Pro Asn Leu Leu Asn 
    290                 295                 300                 


Gly Gln Leu Ser Ser Pro Leu His Phe Ala Ala Gly Gly Gly His Ala 
305                 310                 315                 320 


Glu Ile Val Gln Ile Leu Leu Asn His Pro Glu Thr Asp Arg His Ile 
                325                 330                 335     


Thr Asp Gln Gln Gly Arg Ser Pro Leu Asn Ile Cys Glu Glu Asn Lys 
            340                 345                 350         


Gln Asn Asn Trp Glu Glu Ala Ala Lys Leu Leu Lys Glu Ala Ile Asn 
        355                 360                 365             


Lys Pro Tyr Glu Lys Val Arg Ile Tyr Arg Met Asp Gly Ser Tyr Arg 
    370                 375                 380                 


Ser Val Glu Leu Lys His Gly Asn Asn Thr Thr Val Gln Gln Ile Met 
385                 390                 395                 400 


Glu Gly Met Arg Leu Ser Gln Glu Thr Gln Gln Tyr Phe Thr Ile Trp 
                405                 410                 415     


Ile Cys Ser Glu Asn Leu Ser Leu Gln Leu Lys Pro Tyr His Lys Pro 
            420                 425                 430         


Leu Gln His Val Arg Asp Trp Pro Glu Ile Leu Ala Glu Leu Thr Asn 
        435                 440                 445             


Leu Asp Pro Gln Arg Glu Thr Pro Gln Leu Phe Leu Arg Arg Asp Val 
    450                 455                 460                 


Arg Leu Pro Leu Glu Val Glu Lys Gln Ile Glu Asp Pro Leu Ala Ile 
465                 470                 475                 480 


Leu Ile Leu Phe Asp Glu Ala Arg Tyr Asn Leu Leu Lys Gly Phe Tyr 
                485                 490                 495     


Thr Ala Pro Asp Ala Lys Leu Ile Thr Leu Ala Ser Leu Leu Leu Gln 
            500                 505                 510         


Ile Val Tyr Gly Asn Tyr Glu Ser Lys Lys His Lys Gln Gly Phe Leu 
        515                 520                 525             


Asn Glu Glu Asn Leu Lys Ser Ile Val Pro Val Thr Lys Leu Lys Ser 
    530                 535                 540                 


Lys Ala Pro His Trp Thr Asn Arg Ile Leu His Glu Tyr Lys Asn Leu 
545                 550                 555                 560 


Ser Thr Ser Glu Gly Val Ser Lys Glu Met His His Leu Gln Arg Met 
                565                 570                 575     


Phe Leu Gln Asn Cys Trp Glu Ile Pro Thr Tyr Gly Ala Ala Phe Phe 
            580                 585                 590         


Thr Gly Gln Ile Phe Thr Lys Ala Ser Pro Ser Asn His Lys Val Ile 
        595                 600                 605             


Pro Val Tyr Val Gly Val Asn Ile Lys Gly Leu His Leu Leu Asn Met 
    610                 615                 620                 


Glu Thr Lys Ala Leu Leu Ile Ser Leu Lys Tyr Gly Cys Phe Met Trp 
625                 630                 635                 640 


Gln Leu Gly Asp Thr Asp Thr Cys Phe Gln Ile His Ser Met Glu Asn 
                645                 650                 655     


Lys Met Ser Phe Ile Val His Thr Lys Gln Ala Gly Leu Val Val Lys 
            660                 665                 670         


Leu Leu Met Lys Leu Asn Gly Gln Leu Met Pro Thr Glu Arg Asn Ser 
        675                 680                 685             


<210>  6013
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT10__Homo_sapiens__NP_000412

<400>  6013

Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser 
            20                  25                  30          


Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser 
        35                  40                  45              


Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly 
    50                  55                  60                  


Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly 
                85                  90                  95      


Ser Tyr Gly Gly Ser Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe 
            100                 105                 110         


Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly 
    130                 135                 140                 


Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr 
145                 150                 155                 160 


Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly 
                165                 170                 175     


Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu 
            180                 185                 190         


Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn 
        195                 200                 205             


Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile 
    210                 215                 220                 


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg 
                245                 250                 255     


Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln 
            260                 265                 270         


Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu 
        275                 280                 285             


Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val 
    290                 295                 300                 


Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn 
305                 310                 315                 320 


Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala 
                325                 330                 335     


Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp 
            340                 345                 350         


Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu 
        355                 360                 365             


Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala 
    370                 375                 380                 


Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr 
385                 390                 395                 400 


Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu 
                405                 410                 415     


Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr 
            420                 425                 430         


Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr 
        435                 440                 445             


Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg 
    450                 455                 460                 


Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Gly His Gly Gly Gly His Gly Gly Ser Ser Gly 
                485                 490                 495     


Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
            500                 505                 510         


Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly 
        515                 520                 525             


Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu 
                565                 570                 575     


Ser Ser Ser Lys Gly Pro Arg Tyr 
            580                 


<210>  6014
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT12__Homo_sapiens__NP_000214

<400>  6014

Met Asp Leu Ser Asn Asn Thr Met Ser Leu Ser Val Arg Thr Pro Gly 
1               5                   10                  15      


Leu Ser Arg Arg Leu Ser Ser Gln Ser Val Ile Gly Arg Pro Arg Gly 
            20                  25                  30          


Met Ser Ala Ser Ser Val Gly Ser Gly Tyr Gly Gly Ser Ala Phe Gly 
        35                  40                  45              


Phe Gly Ala Ser Cys Gly Gly Gly Phe Ser Ala Ala Ser Met Phe Gly 
    50                  55                  60                  


Ser Ser Ser Gly Phe Gly Gly Gly Ser Gly Ser Ser Met Ala Gly Gly 
65                  70                  75                  80  


Leu Gly Ala Gly Tyr Gly Arg Ala Leu Gly Gly Gly Ser Phe Gly Gly 
                85                  90                  95      


Leu Gly Met Gly Phe Gly Gly Ser Pro Gly Gly Gly Ser Leu Gly Ile 
            100                 105                 110         


Leu Ser Gly Asn Asp Gly Gly Leu Leu Ser Gly Ser Glu Lys Glu Thr 
        115                 120                 125             


Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg 
    130                 135                 140                 


Ala Leu Glu Glu Ala Asn Thr Glu Leu Glu Asn Lys Ile Arg Glu Trp 
145                 150                 155                 160 


Tyr Glu Thr Arg Gly Thr Gly Thr Ala Asp Ala Ser Gln Ser Asp Tyr 
                165                 170                 175     


Ser Lys Tyr Tyr Pro Leu Ile Glu Asp Leu Arg Asn Lys Ile Ile Ser 
            180                 185                 190         


Ala Ser Ile Gly Asn Ala Gln Leu Leu Leu Gln Ile Asp Asn Ala Arg 
        195                 200                 205             


Leu Ala Ala Glu Asp Phe Arg Met Lys Tyr Glu Asn Glu Leu Ala Leu 
    210                 215                 220                 


Arg Gln Gly Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp 
225                 230                 235                 240 


Glu Leu Thr Leu Thr Arg Thr Asp Leu Glu Met Gln Ile Glu Ser Leu 
                245                 250                 255     


Asn Glu Glu Leu Ala Tyr Met Lys Lys Asn His Glu Asp Glu Leu Gln 
            260                 265                 270         


Ser Phe Arg Val Gly Gly Pro Gly Glu Val Ser Val Glu Met Asp Ala 
        275                 280                 285             


Ala Pro Gly Val Asp Leu Thr Arg Leu Leu Asn Asp Met Arg Ala Gln 
    290                 295                 300                 


Tyr Glu Thr Ile Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe 
305                 310                 315                 320 


Ile Glu Lys Ser Gly Glu Leu Arg Lys Glu Ile Ser Thr Asn Thr Glu 
                325                 330                 335     


Gln Leu Gln Ser Ser Lys Ser Glu Val Thr Asp Leu Arg Arg Ala Phe 
            340                 345                 350         


Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala Met Lys Lys Ser 
        355                 360                 365             


Leu Glu Asp Ser Leu Ala Glu Ala Glu Gly Asp Tyr Cys Ala Gln Leu 
    370                 375                 380                 


Ser Gln Val Gln Gln Leu Ile Ser Asn Leu Glu Ala Gln Leu Leu Gln 
385                 390                 395                 400 


Val Arg Ala Asp Ala Glu Arg Gln Asn Val Asp His Gln Arg Leu Leu 
                405                 410                 415     


Asn Val Lys Ala Arg Leu Glu Leu Glu Ile Glu Thr Tyr Arg Arg Leu 
            420                 425                 430         


Leu Asp Gly Glu Ala Gln Gly Asp Gly Leu Glu Glu Ser Leu Phe Val 
        435                 440                 445             


Thr Asp Ser Lys Ser Gln Ala Gln Ser Thr Asp Ser Ser Lys Asp Pro 
    450                 455                 460                 


Thr Lys Thr Arg Lys Ile Lys Thr Val Val Gln Glu Met Val Asn Gly 
465                 470                 475                 480 


Glu Val Val Ser Ser Gln Val Gln Glu Ile Glu Glu Leu Met 
                485                 490                 


<210>  6015
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT13__Homo_sapiens__NP_002265

<400>  6015

Met Ser Leu Arg Leu Gln Ser Ser Ser Ala Ser Tyr Gly Gly Gly Phe 
1               5                   10                  15      


Gly Gly Gly Ser Cys Gln Leu Gly Gly Gly Arg Gly Val Ser Thr Cys 
            20                  25                  30          


Ser Thr Arg Phe Val Ser Gly Gly Ser Ala Gly Gly Tyr Gly Gly Gly 
        35                  40                  45              


Val Ser Cys Gly Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Gly Gly 
    50                  55                  60                  


Tyr Gly Gly Gly Leu Gly Gly Gly Tyr Gly Gly Gly Leu Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Phe Ala Gly Gly Phe Val Asp Phe Gly Ala Cys Asp 
                85                  90                  95      


Gly Gly Leu Leu Thr Gly Asn Glu Lys Ile Thr Met Gln Asn Leu Asn 
            100                 105                 110         


Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg Ala Leu Glu Glu Ala 
        115                 120                 125             


Asn Ala Asp Leu Glu Val Lys Ile Arg Asp Trp His Leu Lys Gln Ser 
    130                 135                 140                 


Pro Ala Ser Pro Glu Arg Asp Tyr Ser Pro Tyr Tyr Lys Thr Ile Glu 
145                 150                 155                 160 


Glu Leu Arg Asp Lys Ile Leu Thr Ala Thr Ile Glu Asn Asn Arg Val 
                165                 170                 175     


Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu 
            180                 185                 190         


Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Ser Val Glu Ala Asp Ile 
        195                 200                 205             


Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ser Lys Thr Asp 
    210                 215                 220                 


Leu Glu Met Gln Ile Glu Ser Leu Asn Glu Glu Leu Ala Tyr Met Lys 
225                 230                 235                 240 


Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Asn Gln Val Val Gly 
                245                 250                 255     


Gln Val Asn Val Glu Met Asp Ala Thr Pro Gly Ile Asp Leu Thr Arg 
            260                 265                 270         


Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu Arg Asn 
        275                 280                 285             


Arg Arg Asp Ala Glu Glu Trp Phe His Ala Lys Ser Ala Glu Leu Asn 
    290                 295                 300                 


Lys Glu Val Ser Thr Asn Thr Ala Met Ile Gln Thr Ser Lys Thr Glu 
305                 310                 315                 320 


Ile Thr Glu Leu Arg Arg Thr Leu Gln Gly Leu Glu Ile Glu Leu Gln 
                325                 330                 335     


Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Thr Val Ala Glu Thr 
            340                 345                 350         


Glu Cys Arg Tyr Ala Leu Gln Leu Gln Gln Ile Gln Gly Leu Ile Ser 
        355                 360                 365             


Ser Ile Glu Ala Gln Leu Ser Glu Leu Arg Ser Glu Met Glu Cys Gln 
    370                 375                 380                 


Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu Glu Gln 
385                 390                 395                 400 


Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala Lys Lys 
                405                 410                 415     


Arg Gln Pro Pro 
            420 


<210>  6016
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT14__Homo_sapiens__NP_000517

<400>  6016

Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Ser Arg Phe Ser Ser Gly Gly Ala Tyr Gly 
    50                  55                  60                  


Leu Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Ser Phe 
65                  70                  75                  80  


Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Ala Gly Leu 
                85                  90                  95      


Gly Gly Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu Leu Val 
            100                 105                 110         


Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser 
        115                 120                 125             


Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu 
    130                 135                 140                 


Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ala Glu Ile Lys 
145                 150                 155                 160 


Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn Lys Ile 
                165                 170                 175     


Leu Thr Ala Thr Val Asp Asn Ala Asn Val Leu Leu Gln Ile Asp Asn 
            180                 185                 190         


Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu Thr Glu Leu 
        195                 200                 205             


Asn Leu Arg Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val 
    210                 215                 220                 


Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile Glu 
225                 230                 235                 240 


Ser Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu 
                245                 250                 255     


Met Asn Ala Leu Arg Gly Gln Val Gly Gly Asp Val Asn Val Glu Met 
            260                 265                 270         


Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met Arg 
        275                 280                 285             


Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu Glu 
    290                 295                 300                 


Trp Phe Phe Thr Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr Asn 
305                 310                 315                 320 


Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg Arg 
                325                 330                 335     


Thr Met Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys 
            340                 345                 350         


Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr Cys Met 
        355                 360                 365             


Gln Leu Ala Gln Ile Gln Glu Met Ile Gly Ser Val Glu Glu Gln Leu 
    370                 375                 380                 


Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys Ile 
385                 390                 395                 400 


Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg 
                405                 410                 415     


Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Ser Gln Phe Ser 
            420                 425                 430         


Ser Gly Ser Gln Ser Ser Arg Asp Val Thr Ser Ser Ser Arg Gln Ile 
        435                 440                 445             


Arg Thr Lys Val Met Asp Val His Asp Gly Lys Val Val Ser Thr His 
    450                 455                 460                 


Glu Gln Val Leu Arg Thr Lys Asn 
465                 470         


<210>  6017
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT15__Homo_sapiens__NP_002266

<400>  6017

Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly Gly 
1               5                   10                  15      


Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly Gly 
            20                  25                  30          


Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser Ser 
        35                  40                  45              


Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly Met 
    50                  55                  60                  


Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly 
                85                  90                  95      


Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn Leu 
            100                 105                 110         


Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu 
        115                 120                 125             


Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys Gln 
    130                 135                 140                 


Thr Pro Thr Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser Arg 
                165                 170                 175     


Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg 
            180                 185                 190         


Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala Asp 
        195                 200                 205             


Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr 
    210                 215                 220                 


Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr Leu 
225                 230                 235                 240 


Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu Ala 
                245                 250                 255     


Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu Thr 
            260                 265                 270         


Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu Lys 
        275                 280                 285             


Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu Leu 
    290                 295                 300                 


Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys Thr 
305                 310                 315                 320 


Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu Leu 
                325                 330                 335     


Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala Glu 
            340                 345                 350         


Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu Ile 
        355                 360                 365             


Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu Ala 
    370                 375                 380                 


Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu Glu 
385                 390                 395                 400 


Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala Lys 
                405                 410                 415     


Met Ala Gly Ile Gly Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln Val 
        435                 440                 445             


Val Ser Ser His Lys Arg Glu Ile 
    450                 455     


<210>  6018
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT16__Homo_sapiens__NP_005548

<400>  6018

Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Arg Phe Ser Ser Gly Gly Ala Cys Gly Leu 
    50                  55                  60                  


Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Phe Gly Ser 
65                  70                  75                  80  


Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Ala Gly Phe Gly Gly 
                85                  90                  95      


Gly Leu Gly Ala Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu 
            100                 105                 110         


Leu Val Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu 
        115                 120                 125             


Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp 
    130                 135                 140                 


Leu Glu Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ser Glu 
145                 150                 155                 160 


Ile Lys Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn 
                165                 170                 175     


Lys Ile Ile Ala Ala Thr Ile Glu Asn Ala Gln Pro Ile Leu Gln Ile 
            180                 185                 190         


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu His 
        195                 200                 205             


Glu Leu Ala Leu Arg Gln Thr Val Glu Ala Asp Val Asn Gly Leu Arg 
    210                 215                 220                 


Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln 
225                 230                 235                 240 


Ile Glu Gly Leu Lys Glu Glu Leu Ala Tyr Leu Arg Lys Asn His Glu 
                245                 250                 255     


Glu Glu Met Leu Ala Leu Arg Gly Gln Thr Gly Gly Asp Val Asn Val 
            260                 265                 270         


Glu Met Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu 
        275                 280                 285             


Met Arg Asp Gln Tyr Glu Gln Met Ala Glu Lys Asn Arg Arg Asp Ala 
    290                 295                 300                 


Glu Thr Trp Phe Leu Ser Lys Thr Glu Glu Leu Asn Lys Glu Val Ala 
305                 310                 315                 320 


Ser Asn Ser Glu Leu Val Gln Ser Ser Arg Ser Glu Val Thr Glu Leu 
                325                 330                 335     


Arg Arg Val Leu Gln Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser 
            340                 345                 350         


Met Lys Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr 
        355                 360                 365             


Cys Met Gln Leu Ser Gln Ile Gln Gly Leu Ile Gly Ser Val Glu Glu 
    370                 375                 380                 


Gln Leu Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Ser Gln Glu Tyr 
385                 390                 395                 400 


Gln Ile Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr 
                405                 410                 415     


Tyr Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Gln Gln 
            420                 425                 430         


Ala Ser Gly Gln Ser Tyr Ser Ser Arg Glu Val Phe Thr Ser Ser Ser 
        435                 440                 445             


Ser Ser Ser Ser Arg Gln Thr Arg Pro Ile Leu Lys Glu Gln Ser Ser 
    450                 455                 460                 


Ser Ser Phe Ser Gln Gly Gln Ser Ser 
465                 470             


<210>  6019
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT17__Homo_sapiens__NP_000413

<400>  6019

Met Thr Thr Ser Ile Arg Gln Phe Thr Ser Ser Ser Ser Ile Lys Gly 
1               5                   10                  15      


Ser Ser Gly Leu Gly Gly Gly Ser Ser Arg Thr Ser Cys Arg Leu Ser 
            20                  25                  30          


Gly Gly Leu Gly Ala Gly Ser Cys Arg Leu Gly Ser Ala Gly Gly Leu 
        35                  40                  45              


Gly Ser Thr Leu Gly Gly Ser Ser Tyr Ser Ser Cys Tyr Ser Phe Gly 
    50                  55                  60                  


Ser Gly Gly Gly Tyr Gly Ser Ser Phe Gly Gly Val Asp Gly Leu Leu 
65                  70                  75                  80  


Ala Gly Gly Glu Lys Ala Thr Met Gln Asn Leu Asn Asp Arg Leu Ala 
                85                  90                  95      


Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Thr Glu Leu 
            100                 105                 110         


Glu Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Ala Pro Gly Pro Ala 
        115                 120                 125             


Arg Asp Tyr Ser Gln Tyr Tyr Arg Thr Ile Glu Glu Leu Gln Asn Lys 
    130                 135                 140                 


Ile Leu Thr Ala Thr Val Asp Asn Ala Asn Ile Leu Leu Gln Ile Asp 
145                 150                 155                 160 


Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu 
                165                 170                 175     


Gln Ala Leu Arg Leu Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg 
            180                 185                 190         


Val Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile 
        195                 200                 205             


Glu Asn Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu 
    210                 215                 220                 


Glu Met Asn Ala Leu Arg Gly Gln Val Gly Gly Glu Ile Asn Val Glu 
225                 230                 235                 240 


Met Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met 
                245                 250                 255     


Arg Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu 
            260                 265                 270         


Asp Trp Phe Phe Ser Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr 
        275                 280                 285             


Asn Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg 
    290                 295                 300                 


Arg Thr Met Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met 
305                 310                 315                 320 


Lys Ala Ser Leu Glu Gly Asn Leu Ala Glu Thr Glu Asn Arg Tyr Cys 
                325                 330                 335     


Val Gln Leu Ser Gln Ile Gln Gly Leu Ile Gly Ser Val Glu Glu Gln 
            340                 345                 350         


Leu Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys 
        355                 360                 365             


Ile Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr 
    370                 375                 380                 


Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Thr Gln Tyr Lys Lys 
385                 390                 395                 400 


Glu Pro Val Thr Thr Arg Gln Val Arg Thr Ile Val Glu Glu Val Gln 
                405                 410                 415     


Asp Gly Lys Val Ile Ser Ser Arg Glu Gln Val His Gln Thr Thr Arg 
            420                 425                 430         


<210>  6020
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT18__Homo_sapiens__NP_000215

<400>  6020

Met Ser Phe Thr Thr Arg Ser Thr Phe Ser Thr Asn Tyr Arg Ser Leu 
1               5                   10                  15      


Gly Ser Val Gln Ala Pro Ser Tyr Gly Ala Arg Pro Val Ser Ser Ala 
            20                  25                  30          


Ala Ser Val Tyr Ala Gly Ala Gly Gly Ser Gly Ser Arg Ile Ser Val 
        35                  40                  45              


Ser Arg Ser Thr Ser Phe Arg Gly Gly Met Gly Ser Gly Gly Leu Ala 
    50                  55                  60                  


Thr Gly Ile Ala Gly Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Glu 
65                  70                  75                  80  


Lys Glu Thr Met Gln Ser Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp 
                85                  90                  95      


Arg Val Arg Ser Leu Glu Thr Glu Asn Arg Arg Leu Glu Ser Lys Ile 
            100                 105                 110         


Arg Glu His Leu Glu Lys Lys Gly Pro Gln Val Arg Asp Trp Ser His 
        115                 120                 125             


Tyr Phe Lys Ile Ile Glu Asp Leu Arg Ala Gln Ile Phe Ala Asn Thr 
    130                 135                 140                 


Val Asp Asn Ala Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu Ala 
145                 150                 155                 160 


Ala Asp Asp Phe Arg Val Lys Tyr Glu Thr Glu Leu Ala Met Arg Gln 
                165                 170                 175     


Ser Val Glu Asn Asp Ile His Gly Leu Arg Lys Val Ile Asp Asp Thr 
            180                 185                 190         


Asn Ile Thr Arg Leu Gln Leu Glu Thr Glu Ile Glu Ala Leu Lys Glu 
        195                 200                 205             


Glu Leu Leu Phe Met Lys Lys Asn His Glu Glu Glu Val Lys Gly Leu 
    210                 215                 220                 


Gln Ala Gln Ile Ala Ser Ser Gly Leu Thr Val Glu Val Asp Ala Pro 
225                 230                 235                 240 


Lys Ser Gln Asp Leu Ala Lys Ile Met Ala Asp Ile Arg Ala Gln Tyr 
                245                 250                 255     


Asp Glu Leu Ala Arg Lys Asn Arg Glu Glu Leu Asp Lys Tyr Trp Ser 
            260                 265                 270         


Gln Gln Ile Glu Glu Ser Thr Thr Val Val Thr Thr Gln Ser Ala Glu 
        275                 280                 285             


Val Gly Ala Ala Glu Thr Thr Leu Thr Glu Leu Arg Arg Thr Val Gln 
    290                 295                 300                 


Ser Leu Glu Ile Asp Leu Asp Ser Met Arg Asn Leu Lys Ala Ser Leu 
305                 310                 315                 320 


Glu Asn Ser Leu Arg Glu Val Glu Ala Arg Tyr Ala Leu Gln Met Glu 
                325                 330                 335     


Gln Leu Asn Gly Ile Leu Leu His Leu Glu Ser Glu Leu Ala Gln Thr 
            340                 345                 350         


Arg Ala Glu Gly Gln Arg Gln Ala Gln Glu Tyr Glu Ala Leu Leu Asn 
        355                 360                 365             


Ile Lys Val Lys Leu Glu Ala Glu Ile Ala Thr Tyr Arg Arg Leu Leu 
    370                 375                 380                 


Glu Asp Gly Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp Ser Ser Asn 
385                 390                 395                 400 


Ser Met Gln Thr Ile Gln Lys Thr Thr Thr Arg Arg Ile Val Asp Gly 
                405                 410                 415     


Lys Val Val Ser Glu Thr Asn Asp Thr Lys Val Leu Arg His 
            420                 425                 430 


<210>  6021
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT19__Homo_sapiens__NP_002267

<400>  6021

Met Thr Ser Tyr Ser Tyr Arg Gln Ser Ser Ala Thr Ser Ser Phe Gly 
1               5                   10                  15      


Gly Leu Gly Gly Gly Ser Val Arg Phe Gly Pro Gly Val Ala Phe Arg 
            20                  25                  30          


Ala Pro Ser Ile His Gly Gly Ser Gly Gly Arg Gly Val Ser Val Ser 
        35                  40                  45              


Ser Ala Arg Phe Val Ser Ser Ser Ser Ser Gly Ala Tyr Gly Gly Gly 
    50                  55                  60                  


Tyr Gly Gly Val Leu Thr Ala Ser Asp Gly Leu Leu Ala Gly Asn Glu 
65                  70                  75                  80  


Lys Leu Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp 
                85                  90                  95      


Lys Val Arg Ala Leu Glu Ala Ala Asn Gly Glu Leu Glu Val Lys Ile 
            100                 105                 110         


Arg Asp Trp Tyr Gln Lys Gln Gly Pro Gly Pro Ser Arg Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Thr Thr Ile Gln Asp Leu Arg Asp Lys Ile Leu Gly Ala 
    130                 135                 140                 


Thr Ile Glu Asn Ser Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu 
145                 150                 155                 160 


Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln Ala Leu Arg 
                165                 170                 175     


Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu 
            180                 185                 190         


Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Lys 
        195                 200                 205             


Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu Ile Ser Thr 
    210                 215                 220                 


Leu Arg Gly Gln Val Gly Gly Gln Val Ser Val Glu Val Asp Ser Ala 
225                 230                 235                 240 


Pro Gly Thr Asp Leu Ala Lys Ile Leu Ser Asp Met Arg Ser Gln Tyr 
                245                 250                 255     


Glu Val Met Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Thr 
            260                 265                 270         


Ser Arg Thr Glu Glu Leu Asn Arg Glu Val Ala Gly His Thr Glu Gln 
        275                 280                 285             


Leu Gln Met Ser Arg Ser Glu Val Thr Asp Leu Arg Arg Thr Leu Gln 
    290                 295                 300                 


Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ala Leu 
305                 310                 315                 320 


Glu Asp Thr Leu Ala Glu Thr Glu Ala Arg Phe Gly Ala Gln Leu Ala 
                325                 330                 335     


His Ile Gln Ala Leu Ile Ser Gly Ile Glu Ala Gln Leu Gly Asp Val 
            340                 345                 350         


Arg Ala Asp Ser Glu Arg Gln Asn Gln Glu Tyr Gln Arg Leu Met Asp 
        355                 360                 365             


Ile Lys Ser Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu 
    370                 375                 380                 


Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser Lys Val Leu 
385                 390                 395                 400 


<210>  6022
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT1__Homo_sapiens__NP_006112

<400>  6022

Met Ser Arg Gln Phe Ser Ser Arg Ser Gly Tyr Arg Ser Gly Gly Gly 
1               5                   10                  15      


Phe Ser Ser Gly Ser Ala Gly Ile Ile Asn Tyr Gln Arg Arg Thr Thr 
            20                  25                  30          


Ser Ser Ser Thr Arg Arg Ser Gly Gly Gly Gly Gly Arg Phe Ser Ser 
        35                  40                  45              


Cys Gly Gly Gly Gly Gly Ser Phe Gly Ala Gly Gly Gly Phe Gly Ser 
    50                  55                  60                  


Arg Ser Leu Val Asn Leu Gly Gly Ser Lys Ser Ile Ser Ile Ser Val 
65                  70                  75                  80  


Ala Arg Gly Gly Gly Arg Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly 
                85                  90                  95      


Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Gly Gly 
            100                 105                 110         


Gly Ile Gly Gly Gly Gly Phe Gly Gly Phe Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Tyr Gly Gly Gly Tyr Gly 
    130                 135                 140                 


Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Ile Asn Gln Ser 
145                 150                 155                 160 


Leu Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Glu Ile Gln Lys Val 
                165                 170                 175     


Lys Ser Arg Glu Arg Glu Gln Ile Lys Ser Leu Asn Asn Gln Phe Ala 
            180                 185                 190         


Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu 
        195                 200                 205             


Gln Thr Lys Trp Glu Leu Leu Gln Gln Val Asp Thr Ser Thr Arg Thr 
    210                 215                 220                 


His Asn Leu Glu Pro Tyr Phe Glu Ser Phe Ile Asn Asn Leu Arg Arg 
225                 230                 235                 240 


Arg Val Asp Gln Leu Lys Ser Asp Gln Ser Arg Leu Asp Ser Glu Leu 
                245                 250                 255     


Lys Asn Met Gln Asp Met Val Glu Asp Tyr Arg Asn Lys Tyr Glu Asp 
            260                 265                 270         


Glu Ile Asn Lys Arg Thr Asn Ala Glu Asn Glu Phe Val Thr Ile Lys 
        275                 280                 285             


Lys Asp Val Asp Gly Ala Tyr Met Thr Lys Val Asp Leu Gln Ala Lys 
    290                 295                 300                 


Leu Asp Asn Leu Gln Gln Glu Ile Asp Phe Leu Thr Ala Leu Tyr Gln 
305                 310                 315                 320 


Ala Glu Leu Ser Gln Met Gln Thr Gln Ile Ser Glu Thr Asn Val Ile 
                325                 330                 335     


Leu Ser Met Asp Asn Asn Arg Ser Leu Asp Leu Asp Ser Ile Ile Ala 
            340                 345                 350         


Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Gln Lys Ser Lys Ala Glu 
        355                 360                 365             


Ala Glu Ser Leu Tyr Gln Ser Lys Tyr Glu Glu Leu Gln Ile Thr Ala 
    370                 375                 380                 


Gly Arg His Gly Asp Ser Val Arg Asn Ser Lys Ile Glu Ile Ser Glu 
385                 390                 395                 400 


Leu Asn Arg Val Ile Gln Arg Leu Arg Ser Glu Ile Asp Asn Val Lys 
                405                 410                 415     


Lys Gln Ile Ser Asn Leu Gln Gln Ser Ile Ser Asp Ala Glu Gln Arg 
            420                 425                 430         


Gly Glu Asn Ala Leu Lys Asp Ala Lys Asn Lys Leu Asn Asp Leu Glu 
        435                 440                 445             


Asp Ala Leu Gln Gln Ala Lys Glu Asp Leu Ala Arg Leu Leu Arg Asp 
    450                 455                 460                 


Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp Leu Glu Ile Ala 
465                 470                 475                 480 


Thr Tyr Arg Thr Leu Leu Glu Gly Glu Glu Ser Arg Met Ser Gly Glu 
                485                 490                 495     


Cys Ala Pro Asn Val Ser Val Ser Val Ser Thr Ser His Thr Thr Ile 
            500                 505                 510         


Ser Gly Gly Gly Ser Arg Gly Gly Gly Gly Gly Gly Tyr Gly Ser Gly 
        515                 520                 525             


Gly Ser Ser Tyr Gly Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Gly Gly Gly Arg Gly Ser Tyr Gly Ser Gly Gly Ser Ser Tyr Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Ser Tyr Gly Ser Gly Gly Gly Gly Gly Gly His Gly 
                565                 570                 575     


Ser Tyr Gly Ser Gly Ser Ser Ser Gly Gly Tyr Arg Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Gly Gly Ser Ser Gly Gly Arg Gly Ser Gly Gly Gly Ser 
        595                 600                 605             


Ser Gly Gly Ser Ile Gly Gly Arg Gly Ser Ser Ser Gly Gly Val Lys 
    610                 615                 620                 


Ser Ser Gly Gly Ser Ser Ser Val Lys Phe Val Ser Thr Thr Tyr Ser 
625                 630                 635                 640 


Gly Val Thr Arg 
                


<210>  6023
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT20__Homo_sapiens__NP_061883

<400>  6023

Met Asp Phe Ser Arg Arg Ser Phe His Arg Ser Leu Ser Ser Ser Leu 
1               5                   10                  15      


Gln Ala Pro Val Val Ser Thr Val Gly Met Gln Arg Leu Gly Thr Thr 
            20                  25                  30          


Pro Ser Val Tyr Gly Gly Ala Gly Gly Arg Gly Ile Arg Ile Ser Asn 
        35                  40                  45              


Ser Arg His Thr Val Asn Tyr Gly Ser Asp Leu Thr Gly Gly Gly Asp 
    50                  55                  60                  


Leu Phe Val Gly Asn Glu Lys Met Ala Met Gln Asn Leu Asn Asp Arg 
65                  70                  75                  80  


Leu Ala Ser Tyr Leu Glu Lys Val Arg Thr Leu Glu Gln Ser Asn Ser 
                85                  90                  95      


Lys Leu Glu Val Gln Ile Lys Gln Trp Tyr Glu Thr Asn Ala Pro Arg 
            100                 105                 110         


Ala Gly Arg Asp Tyr Ser Ala Tyr Tyr Arg Gln Ile Glu Glu Leu Arg 
        115                 120                 125             


Ser Gln Ile Lys Asp Ala Gln Leu Gln Asn Ala Arg Cys Val Leu Gln 
    130                 135                 140                 


Ile Asp Asn Ala Lys Leu Ala Ala Glu Asp Phe Arg Leu Lys Tyr Glu 
145                 150                 155                 160 


Thr Glu Arg Gly Ile Arg Leu Thr Val Glu Ala Asp Leu Gln Gly Leu 
                165                 170                 175     


Asn Lys Val Phe Asp Asp Leu Thr Leu His Lys Thr Asp Leu Glu Ile 
            180                 185                 190         


Gln Ile Glu Glu Leu Asn Lys Asp Leu Ala Leu Leu Lys Lys Glu His 
        195                 200                 205             


Gln Glu Glu Val Asp Gly Leu His Lys His Leu Gly Asn Thr Val Asn 
    210                 215                 220                 


Val Glu Val Asp Ala Ala Pro Gly Leu Asn Leu Gly Val Ile Met Asn 
225                 230                 235                 240 


Glu Met Arg Gln Lys Tyr Glu Val Met Ala Gln Lys Asn Leu Gln Glu 
                245                 250                 255     


Ala Lys Glu Gln Phe Glu Arg Gln Thr Ala Val Leu Gln Gln Gln Val 
            260                 265                 270         


Thr Val Asn Thr Glu Glu Leu Lys Gly Thr Glu Val Gln Leu Thr Glu 
        275                 280                 285             


Leu Arg Arg Thr Ser Gln Ser Leu Glu Ile Glu Leu Gln Ser His Leu 
    290                 295                 300                 


Ser Met Lys Glu Ser Leu Glu His Thr Leu Glu Glu Thr Lys Ala Arg 
305                 310                 315                 320 


Tyr Ser Ser Gln Leu Ala Asn Leu Gln Ser Leu Leu Ser Ser Leu Glu 
                325                 330                 335     


Ala Gln Leu Met Gln Ile Arg Ser Asn Met Glu Arg Gln Asn Asn Glu 
            340                 345                 350         


Tyr His Ile Leu Leu Asp Ile Lys Thr Arg Leu Glu Gln Glu Ile Ala 
        355                 360                 365             


Thr Tyr Arg Arg Leu Leu Glu Gly Glu Asp Val Lys Thr Thr Glu Tyr 
    370                 375                 380                 


Gln Leu Ser Thr Leu Glu Glu Arg Asp Ile Lys Lys Thr Arg Lys Ile 
385                 390                 395                 400 


Lys Thr Val Val Gln Glu Val Val Asp Gly Lys Val Val Ser Ser Glu 
                405                 410                 415     


Val Lys Glu Val Glu Glu Asn Ile 
            420                 


<210>  6024
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT23__Homo_sapiens__NP_056330

<400>  6024

Met Asn Ser Gly His Ser Phe Ser Gln Thr Pro Ser Ala Ser Phe His 
1               5                   10                  15      


Gly Ala Gly Gly Gly Trp Gly Arg Pro Arg Ser Phe Pro Arg Ala Pro 
            20                  25                  30          


Thr Val His Gly Gly Ala Gly Gly Ala Arg Ile Ser Leu Ser Phe Thr 
        35                  40                  45              


Thr Arg Ser Cys Pro Pro Pro Gly Gly Ser Trp Gly Ser Gly Arg Ser 
    50                  55                  60                  


Ser Pro Leu Leu Gly Gly Asn Gly Lys Ala Thr Met Gln Asn Leu Asn 
65                  70                  75                  80  


Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg Ala Leu Glu Glu Ala 
                85                  90                  95      


Asn Met Lys Leu Glu Ser Arg Ile Leu Lys Trp His Gln Gln Arg Asp 
            100                 105                 110         


Pro Gly Ser Lys Lys Asp Tyr Ser Gln Tyr Glu Glu Asn Ile Thr His 
        115                 120                 125             


Leu Gln Glu Gln Ile Val Asp Gly Lys Met Thr Asn Ala Gln Ile Ile 
    130                 135                 140                 


Leu Leu Ile Asp Asn Ala Arg Met Ala Val Asp Asp Phe Asn Leu Lys 
145                 150                 155                 160 


Tyr Glu Asn Glu His Ser Phe Lys Lys Asp Leu Glu Ile Glu Val Glu 
                165                 170                 175     


Gly Leu Arg Arg Thr Leu Asp Asn Leu Thr Ile Val Thr Thr Asp Leu 
            180                 185                 190         


Glu Gln Glu Val Glu Gly Met Arg Lys Glu Leu Ile Leu Met Lys Lys 
        195                 200                 205             


His His Glu Gln Glu Met Glu Lys His His Val Pro Ser Asp Phe Asn 
    210                 215                 220                 


Val Asn Val Lys Val Asp Thr Gly Pro Arg Glu Asp Leu Ile Lys Val 
225                 230                 235                 240 


Leu Glu Asp Met Arg Gln Glu Tyr Glu Leu Ile Ile Lys Lys Lys His 
                245                 250                 255     


Arg Asp Leu Asp Thr Trp Tyr Lys Glu Gln Ser Ala Ala Met Ser Gln 
            260                 265                 270         


Glu Ala Ala Ser Pro Ala Thr Val Gln Ser Arg Gln Gly Asp Ile His 
        275                 280                 285             


Glu Leu Lys Arg Thr Phe Gln Ala Leu Glu Ile Asp Leu Gln Thr Gln 
    290                 295                 300                 


Tyr Ser Thr Lys Ser Ala Leu Glu Asn Met Leu Ser Glu Thr Gln Ser 
305                 310                 315                 320 


Arg Tyr Ser Cys Lys Leu Gln Asp Met Gln Glu Ile Ile Ser His Tyr 
                325                 330                 335     


Glu Glu Glu Leu Thr Gln Leu Arg His Glu Leu Glu Arg Gln Asn Asn 
            340                 345                 350         


Glu Tyr Gln Val Leu Leu Gly Ile Lys Thr His Leu Glu Lys Glu Ile 
        355                 360                 365             


Thr Thr Tyr Arg Arg Leu Leu Glu Gly Glu Ser Glu Gly Thr Arg Glu 
    370                 375                 380                 


Glu Ser Lys Ser Ser Met Lys Val Ser Ala Thr Pro Lys Ile Lys Ala 
385                 390                 395                 400 


Ile Thr Gln Glu Thr Ile Asn Gly Arg Leu Val Leu Cys Gln Val Asn 
                405                 410                 415     


Glu Ile Gln Lys His Ala 
            420         


<210>  6025
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT2__Homo_sapiens__NP_000414

<400>  6025

Met Ser Cys Gln Ile Ser Cys Lys Ser Arg Gly Arg Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Phe Arg Gly Phe Ser Ser Gly Ser Ala Val Val Ser Gly Gly 
            20                  25                  30          


Ser Arg Arg Ser Thr Ser Ser Phe Ser Cys Leu Ser Arg His Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly Ser Arg Ser Leu Val 
    50                  55                  60                  


Gly Leu Gly Gly Thr Lys Ser Ile Ser Ile Ser Val Ala Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Phe Gly Ala Ala Gly Gly Phe Gly Gly Arg Gly Gly Gly Phe 
                85                  90                  95      


Gly Gly Gly Ser Ser Phe Gly Gly Gly Ser Gly Phe Ser Gly Gly Gly 
            100                 105                 110         


Phe Gly Gly Gly Gly Phe Gly Gly Gly Arg Phe Gly Gly Phe Gly Gly 
        115                 120                 125             


Pro Gly Gly Val Gly Gly Leu Gly Gly Pro Gly Gly Phe Gly Pro Gly 
    130                 135                 140                 


Gly Tyr Pro Gly Gly Ile His Glu Val Ser Val Asn Gln Ser Leu Leu 
145                 150                 155                 160 


Gln Pro Leu Asn Val Lys Val Asp Pro Glu Ile Gln Asn Val Lys Ala 
                165                 170                 175     


Gln Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser Phe 
            180                 185                 190         


Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu Gln Thr 
        195                 200                 205             


Lys Trp Glu Leu Leu Gln Gln Met Asn Val Gly Thr Arg Pro Ile Asn 
    210                 215                 220                 


Leu Glu Pro Ile Phe Gln Gly Tyr Ile Asp Ser Leu Lys Arg Tyr Leu 
225                 230                 235                 240 


Asp Gly Leu Thr Ala Glu Arg Thr Ser Gln Asn Ser Glu Leu Asn Asn 
                245                 250                 255     


Met Gln Asp Leu Val Glu Asp Tyr Lys Lys Lys Tyr Glu Asp Glu Ile 
            260                 265                 270         


Asn Lys Arg Thr Ala Ala Glu Asn Asp Phe Val Thr Leu Lys Lys Asp 
        275                 280                 285             


Val Asp Asn Ala Tyr Met Ile Lys Val Glu Leu Gln Ser Lys Val Asp 
    290                 295                 300                 


Leu Leu Asn Gln Glu Ile Glu Phe Leu Lys Val Leu Tyr Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Gln Ile His Gln Ser Val Thr Asp Thr Asn Val Ile Leu Ser 
                325                 330                 335     


Met Asp Asn Ser Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu Val 
            340                 345                 350         


Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Lys Glu Glu Ala Glu 
        355                 360                 365             


Ala Leu Tyr His Ser Lys Tyr Glu Glu Leu Gln Val Thr Val Gly Arg 
    370                 375                 380                 


His Gly Asp Ser Leu Lys Glu Ile Lys Ile Glu Ile Ser Glu Leu Asn 
385                 390                 395                 400 


Arg Val Ile Gln Arg Leu Gln Gly Glu Ile Ala His Val Lys Lys Gln 
                405                 410                 415     


Cys Lys Asn Val Gln Asp Ala Ile Ala Asp Ala Glu Gln Arg Gly Glu 
            420                 425                 430         


His Ala Leu Lys Asp Ala Arg Asn Lys Leu Asn Asp Leu Glu Glu Ala 
        435                 440                 445             


Leu Gln Gln Ala Lys Glu Asp Leu Ala Arg Leu Leu Arg Asp Tyr Gln 
    450                 455                 460                 


Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr Tyr 
465                 470                 475                 480 


Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Met Ser Gly Asp Leu Ser 
                485                 490                 495     


Ser Asn Val Thr Val Ser Val Thr Ser Ser Thr Ile Ser Ser Asn Val 
            500                 505                 510         


Ala Ser Lys Ala Ala Phe Gly Gly Ser Gly Gly Arg Gly Ser Ser Ser 
        515                 520                 525             


Gly Gly Gly Tyr Ser Ser Gly Ser Ser Ser Tyr Gly Ser Gly Gly Arg 
    530                 535                 540                 


Gln Ser Gly Ser Arg Gly Gly Ser Gly Gly Gly Gly Ser Ile Ser Gly 
545                 550                 555                 560 


Gly Gly Tyr Gly Ser Gly Gly Gly Ser Gly Gly Arg Tyr Gly Ser Gly 
                565                 570                 575     


Gly Gly Ser Lys Gly Gly Ser Ile Ser Gly Gly Gly Tyr Gly Ser Gly 
            580                 585                 590         


Gly Gly Lys His Ser Ser Gly Gly Gly Ser Arg Gly Gly Ser Ser Ser 
        595                 600                 605             


Gly Gly Gly Tyr Gly Ser Gly Gly Gly Gly Ser Ser Ser Val Lys Gly 
    610                 615                 620                 


Ser Ser Gly Glu Ala Phe Gly Ser Ser Val Thr Phe Ser Phe Arg 
625                 630                 635                 


<210>  6026
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT31__Homo_sapiens__NP_002268

<400>  6026

Met Pro Tyr Asn Phe Cys Leu Pro Ser Leu Ser Cys Arg Thr Ser Cys 
1               5                   10                  15      


Ser Ser Arg Pro Cys Val Pro Pro Ser Cys His Ser Cys Thr Leu Pro 
            20                  25                  30          


Gly Ala Cys Asn Ile Pro Ala Asn Val Ser Asn Cys Asn Trp Phe Cys 
        35                  40                  45              


Glu Gly Ser Phe Asn Gly Ser Glu Lys Glu Thr Met Gln Phe Leu Asn 
    50                  55                  60                  


Asp Arg Leu Ala Ser Tyr Leu Glu Lys Val Arg Gln Leu Glu Arg Asp 
65                  70                  75                  80  


Asn Ala Glu Leu Glu Asn Leu Ile Arg Glu Arg Ser Gln Gln Gln Glu 
                85                  90                  95      


Pro Leu Leu Cys Pro Ser Tyr Gln Ser Tyr Phe Lys Thr Ile Glu Glu 
            100                 105                 110         


Leu Gln Gln Lys Ile Leu Cys Thr Lys Ser Glu Asn Ala Arg Leu Val 
        115                 120                 125             


Val Gln Ile Asp Asn Ala Lys Leu Ala Ala Asp Asp Phe Arg Thr Lys 
    130                 135                 140                 


Tyr Gln Thr Glu Leu Ser Leu Arg Gln Leu Val Glu Ser Asp Ile Asn 
145                 150                 155                 160 


Gly Leu Arg Arg Ile Leu Asp Glu Leu Thr Leu Cys Lys Ser Asp Leu 
                165                 170                 175     


Glu Ala Gln Val Glu Ser Leu Lys Glu Glu Leu Leu Cys Leu Lys Ser 
            180                 185                 190         


Asn His Glu Gln Glu Val Asn Thr Leu Arg Cys Gln Leu Gly Asp Arg 
        195                 200                 205             


Leu Asn Val Glu Val Asp Ala Ala Pro Thr Val Asp Leu Asn Arg Val 
    210                 215                 220                 


Leu Asn Glu Thr Arg Ser Gln Tyr Glu Ala Leu Val Glu Thr Asn Arg 
225                 230                 235                 240 


Arg Glu Val Glu Gln Trp Phe Thr Thr Gln Thr Glu Glu Leu Asn Lys 
                245                 250                 255     


Gln Val Val Ser Ser Ser Glu Gln Leu Gln Ser Tyr Gln Ala Glu Ile 
            260                 265                 270         


Ile Glu Leu Arg Arg Thr Val Asn Ala Leu Glu Ile Glu Leu Gln Ala 
        275                 280                 285             


Gln His Asn Leu Arg Asp Ser Leu Glu Asn Thr Leu Thr Glu Ser Glu 
    290                 295                 300                 


Ala Arg Tyr Ser Ser Gln Leu Ser Gln Val Gln Ser Leu Ile Thr Asn 
305                 310                 315                 320 


Val Glu Ser Gln Leu Ala Glu Ile Arg Ser Asp Leu Glu Arg Gln Asn 
                325                 330                 335     


Gln Glu Tyr Gln Val Leu Leu Asp Val Arg Ala Arg Leu Glu Cys Glu 
            340                 345                 350         


Ile Asn Thr Tyr Arg Ser Leu Leu Glu Ser Glu Asp Cys Asn Leu Pro 
        355                 360                 365             


Ser Asn Pro Cys Ala Thr Thr Asn Ala Cys Ser Lys Pro Ile Gly Pro 
    370                 375                 380                 


Cys Leu Ser Asn Pro Cys Thr Ser Cys Val Pro Pro Ala Pro Cys Thr 
385                 390                 395                 400 


Pro Cys Ala Pro Arg Pro Arg Cys Gly Pro Cys Asn Ser Phe Val Arg 
                405                 410                 415     


<210>  6027
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT32__Homo_sapiens__NP_002269

<400>  6027

Met Thr Ser Ser Cys Cys Val Thr Asn Asn Leu Gln Ala Ser Leu Lys 
1               5                   10                  15      


Ser Cys Pro Arg Pro Ala Ser Val Cys Ser Ser Gly Val Asn Cys Arg 
            20                  25                  30          


Pro Glu Leu Cys Leu Gly Tyr Val Cys Gln Pro Met Ala Cys Leu Pro 
        35                  40                  45              


Ser Val Cys Leu Pro Thr Thr Phe Arg Pro Ala Ser Cys Leu Ser Lys 
    50                  55                  60                  


Thr Tyr Leu Ser Ser Ser Cys Gln Ala Ala Ser Gly Ile Ser Gly Ser 
65                  70                  75                  80  


Met Gly Pro Gly Ser Trp Tyr Ser Glu Gly Ala Phe Asn Gly Asn Glu 
                85                  90                  95      


Lys Glu Thr Met Gln Phe Leu Asn Asp Arg Leu Ala Ser Tyr Leu Thr 
            100                 105                 110         


Arg Val Arg Gln Leu Glu Gln Glu Asn Ala Glu Leu Glu Ser Arg Ile 
        115                 120                 125             


Gln Glu Ala Ser His Ser Gln Val Leu Thr Met Thr Pro Asp Tyr Gln 
    130                 135                 140                 


Ser His Phe Arg Thr Ile Glu Glu Leu Gln Gln Lys Ile Leu Cys Thr 
145                 150                 155                 160 


Lys Ala Glu Asn Ala Arg Met Val Val Asn Ile Asp Asn Ala Lys Leu 
                165                 170                 175     


Ala Ala Asp Asp Phe Arg Ala Lys Tyr Glu Ala Glu Leu Ala Met Arg 
            180                 185                 190         


Gln Leu Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Ile Leu Asp Asp 
        195                 200                 205             


Leu Thr Leu Cys Lys Ala Asp Leu Glu Ala Gln Val Glu Ser Leu Lys 
    210                 215                 220                 


Glu Glu Leu Met Cys Leu Lys Lys Asn His Glu Glu Glu Val Gly Ser 
225                 230                 235                 240 


Leu Arg Cys Gln Leu Gly Asp Arg Leu Asn Ile Glu Val Asp Ala Ala 
                245                 250                 255     


Pro Pro Val Asp Leu Thr Arg Val Leu Glu Glu Met Arg Cys Gln Tyr 
            260                 265                 270         


Glu Ala Met Val Glu Ala Asn Arg Arg Asp Val Glu Glu Trp Phe Asn 
        275                 280                 285             


Met Gln Met Glu Glu Leu Asn Gln Gln Val Ala Thr Ser Ser Glu Gln 
    290                 295                 300                 


Leu Gln Asn Tyr Gln Ser Asp Ile Ile Asp Leu Arg Arg Thr Val Asn 
305                 310                 315                 320 


Thr Leu Glu Ile Glu Leu Gln Ala Gln His Ser Leu Arg Asp Ser Leu 
                325                 330                 335     


Glu Asn Thr Leu Thr Glu Ser Glu Ala Arg Tyr Ser Ser Gln Leu Ala 
            340                 345                 350         


Gln Met Gln Cys Met Ile Thr Asn Val Glu Ala Gln Leu Ala Glu Ile 
        355                 360                 365             


Arg Ala Asp Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu Leu Asp 
    370                 375                 380                 


Val Arg Ala Arg Leu Glu Gly Glu Ile Asn Thr Tyr Arg Ser Leu Leu 
385                 390                 395                 400 


Glu Asn Glu Asp Cys Lys Leu Pro Cys Asn Pro Cys Ser Thr Pro Ser 
                405                 410                 415     


Cys Thr Thr Cys Val Pro Ser Pro Cys Val Pro Arg Thr Val Cys Val 
            420                 425                 430         


Pro Arg Thr Val Gly Met Pro Cys Ser Pro Cys Pro Gln Gly Arg Tyr 
        435                 440                 445             


<210>  6028
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT34__Homo_sapiens__NP_066293

<400>  6028

Met Leu Tyr Ala Lys Pro Pro Pro Thr Ile Asn Gly Ile Lys Gly Leu 
1               5                   10                  15      


Gln Arg Lys Glu Arg Leu Lys Pro Ala His Ile His Leu Gln Gln Leu 
            20                  25                  30          


Thr Cys Phe Ser Ile Thr Cys Ser Ser Thr Met Ser Tyr Ser Cys Cys 
        35                  40                  45              


Leu Pro Ser Leu Gly Cys Arg Thr Ser Cys Ser Ser Arg Pro Cys Val 
    50                  55                  60                  


Pro Pro Ser Cys His Gly Tyr Thr Leu Pro Gly Ala Cys Asn Ile Pro 
65                  70                  75                  80  


Ala Asn Val Ser Asn Cys Asn Trp Phe Cys Glu Gly Ser Phe Asn Gly 
                85                  90                  95      


Ser Glu Lys Glu Thr Met Gln Phe Leu Asn Asp Arg Leu Ala Ser Tyr 
            100                 105                 110         


Leu Glu Lys Val Arg Gln Leu Glu Arg Asp Asn Ala Glu Leu Glu Lys 
        115                 120                 125             


Leu Ile Gln Glu Arg Ser Gln Gln Gln Glu Pro Leu Leu Cys Pro Ser 
    130                 135                 140                 


Tyr Gln Ser Tyr Phe Lys Thr Ile Glu Glu Leu Gln Gln Lys Ile Leu 
145                 150                 155                 160 


Cys Ala Lys Ala Glu Asn Ala Arg Leu Val Val Asn Ile Asp Asn Ala 
                165                 170                 175     


Lys Leu Ala Ser Asp Asp Phe Arg Ser Lys Tyr Gln Thr Glu Gln Ser 
            180                 185                 190         


Leu Arg Leu Leu Val Glu Ser Asp Ile Asn Ser Ile Arg Arg Ile Leu 
        195                 200                 205             


Asp Glu Leu Thr Leu Cys Lys Ser Asp Leu Glu Ser Gln Val Glu Ser 
    210                 215                 220                 


Leu Arg Glu Glu Leu Ile Cys Leu Lys Lys Asn His Glu Glu Glu Val 
225                 230                 235                 240 


Asn Thr Leu Arg Ser Gln Leu Gly Asp Arg Leu Asn Val Glu Val Asp 
                245                 250                 255     


Thr Ala Pro Thr Val Asp Leu Asn Gln Val Leu Asn Glu Thr Arg Ser 
            260                 265                 270         


Gln Tyr Glu Ala Leu Val Glu Ile Asn Arg Arg Glu Val Glu Gln Trp 
        275                 280                 285             


Phe Ala Thr Gln Thr Glu Glu Leu Asn Lys Gln Val Val Ser Ser Ser 
    290                 295                 300                 


Glu Gln Leu Gln Ser Cys Gln Ala Glu Ile Ile Glu Leu Arg Arg Thr 
305                 310                 315                 320 


Val Asn Ala Leu Glu Ile Glu Leu Gln Ala Gln His Asn Leu Arg Asp 
                325                 330                 335     


Ser Leu Glu Asn Thr Leu Thr Glu Ser Glu Ala His Tyr Ser Ser Gln 
            340                 345                 350         


Leu Ser Gln Val Gln Ser Leu Ile Thr Asn Val Glu Ser Gln Leu Ala 
        355                 360                 365             


Glu Ile Arg Cys Asp Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu 
    370                 375                 380                 


Leu Asp Val Arg Ala Arg Leu Glu Cys Glu Ile Asn Thr Tyr Arg Ser 
385                 390                 395                 400 


Leu Leu Glu Ser Glu Asp Cys Lys Leu Pro Cys Asn Pro Cys Ala Thr 
                405                 410                 415     


Thr Asn Ala Ser Gly Asn Ser Cys Gly Pro Cys Gly Thr Ser Gln Lys 
            420                 425                 430         


Gly Cys Cys Asn 
        435     


<210>  6029
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT35__Homo_sapiens__NP_002271

<400>  6029

Met Ala Ser Lys Cys Leu Lys Ala Gly Phe Ser Ser Gly Ser Leu Lys 
1               5                   10                  15      


Ser Pro Gly Gly Ala Ser Gly Gly Ser Thr Arg Val Ser Ala Met Tyr 
            20                  25                  30          


Ser Ser Ser Ser Cys Lys Leu Pro Ser Leu Ser Pro Val Ala Arg Ser 
        35                  40                  45              


Phe Ser Ala Cys Ser Val Gly Leu Gly Arg Ser Ser Tyr Arg Ala Thr 
    50                  55                  60                  


Ser Cys Leu Pro Ala Leu Cys Leu Pro Ala Gly Gly Phe Ala Thr Ser 
65                  70                  75                  80  


Tyr Ser Gly Gly Gly Gly Trp Phe Gly Glu Gly Ile Leu Thr Gly Asn 
                85                  90                  95      


Glu Lys Glu Thr Met Gln Ser Leu Asn Asp Arg Leu Ala Gly Tyr Leu 
            100                 105                 110         


Glu Lys Val Arg Gln Leu Glu Gln Glu Asn Ala Ser Leu Glu Ser Arg 
        115                 120                 125             


Ile Arg Glu Trp Cys Glu Gln Gln Val Pro Tyr Met Cys Pro Asp Tyr 
    130                 135                 140                 


Gln Ser Tyr Phe Arg Thr Ile Glu Glu Leu Gln Lys Lys Thr Leu Cys 
145                 150                 155                 160 


Ser Lys Ala Glu Asn Ala Arg Leu Val Val Glu Ile Asp Asn Ala Lys 
                165                 170                 175     


Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu Thr Glu Val Ser Leu 
            180                 185                 190         


Arg Gln Leu Val Glu Ser Asp Ile Asn Gly Leu Arg Arg Ile Leu Asp 
        195                 200                 205             


Asp Leu Thr Leu Cys Lys Ser Asp Leu Glu Ala Gln Val Glu Ser Leu 
    210                 215                 220                 


Lys Glu Glu Leu Leu Cys Leu Lys Lys Asn His Glu Glu Glu Val Asn 
225                 230                 235                 240 


Ser Leu Arg Cys Gln Leu Gly Asp Arg Leu Asn Val Glu Val Asp Ala 
                245                 250                 255     


Ala Pro Pro Val Asp Leu Asn Arg Val Leu Glu Glu Met Arg Cys Gln 
            260                 265                 270         


Tyr Glu Thr Leu Val Glu Asn Asn Arg Arg Asp Ala Glu Asp Trp Leu 
        275                 280                 285             


Asp Thr Gln Ser Glu Glu Leu Asn Gln Gln Val Val Ser Ser Ser Glu 
    290                 295                 300                 


Gln Leu Gln Ser Cys Gln Ala Glu Ile Ile Glu Leu Arg Arg Thr Val 
305                 310                 315                 320 


Asn Ala Leu Glu Ile Glu Leu Gln Ala Gln His Ser Met Arg Asp Ala 
                325                 330                 335     


Leu Glu Ser Thr Leu Ala Glu Thr Glu Ala Arg Tyr Ser Ser Gln Leu 
            340                 345                 350         


Ala Gln Met Gln Cys Met Ile Thr Asn Val Glu Ala Gln Leu Ala Glu 
        355                 360                 365             


Ile Arg Ala Asp Leu Glu Arg Gln Asn Gln Glu Tyr Gln Val Leu Leu 
    370                 375                 380                 


Asp Val Arg Ala Arg Leu Glu Cys Glu Ile Asn Thr Tyr Arg Gly Leu 
385                 390                 395                 400 


Leu Glu Ser Glu Asp Ser Lys Leu Pro Cys Asn Pro Cys Ala Pro Asp 
                405                 410                 415     


Tyr Ser Pro Ser Lys Ser Cys Leu Pro Cys Leu Pro Ala Ala Ser Cys 
            420                 425                 430         


Gly Pro Ser Ala Ala Arg Thr Asn Cys Ser Pro Arg Pro Ile Cys Val 
        435                 440                 445             


Pro Cys Pro Gly Gly Arg Phe 
    450                 455 


<210>  6030
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT3__Homo_sapiens__NP_476429

<400>  6030

Met Ser Arg Gln Ala Ser Lys Thr Ser Gly Gly Gly Ser Gln Gly Phe 
1               5                   10                  15      


Ser Gly Arg Ser Ala Val Val Ser Gly Ser Ser Arg Met Ser Cys Val 
            20                  25                  30          


Ala His Ser Gly Gly Ala Gly Gly Gly Ala Tyr Gly Phe Arg Ser Gly 
        35                  40                  45              


Ala Gly Gly Phe Gly Ser Arg Ser Leu Tyr Asn Leu Gly Gly Asn Lys 
    50                  55                  60                  


Ser Ile Ser Ile Ser Val Ala Ala Gly Gly Ser Arg Ala Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Arg Ser Ser Cys Ala Phe Ala Gly Gly Tyr Gly Gly Gly 
                85                  90                  95      


Phe Gly Ser Gly Tyr Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly 
            100                 105                 110         


Arg Gly Met Gly Gly Gly Phe Gly Gly Ala Gly Gly Phe Gly Gly Ala 
        115                 120                 125             


Gly Gly Phe Gly Gly Ala Gly Gly Phe Gly Gly Pro Gly Gly Phe Gly 
    130                 135                 140                 


Gly Ser Gly Gly Phe Gly Gly Pro Gly Ser Leu Gly Ser Pro Gly Gly 
145                 150                 155                 160 


Phe Gly Pro Gly Gly Phe Pro Gly Gly Ile Gln Glu Val Thr Ile Asn 
                165                 170                 175     


Gln Ser Leu Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Gln Ile Gly 
            180                 185                 190         


Gln Val Lys Ala Gln Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys 
        195                 200                 205             


Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys 
    210                 215                 220                 


Val Leu Glu Thr Lys Trp Asn Leu Leu Gln Gln Gln Gly Thr Ser Ser 
225                 230                 235                 240 


Ile Ser Gly Thr Asn Asn Leu Glu Pro Leu Phe Glu Asn His Ile Asn 
                245                 250                 255     


Tyr Leu Arg Ser Tyr Leu Asp Asn Ile Leu Gly Glu Arg Gly Arg Leu 
            260                 265                 270         


Asp Ser Glu Leu Lys Asn Met Glu Asp Leu Val Glu Asp Phe Lys Lys 
        275                 280                 285             


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe 
    290                 295                 300                 


Val Thr Leu Lys Lys Asp Val Asp Ser Ala Tyr Met Asn Lys Val Glu 
305                 310                 315                 320 


Leu Gln Ala Lys Val Asp Ala Leu Ile Asp Glu Ile Asp Phe Leu Arg 
                325                 330                 335     


Thr Leu Tyr Asp Ala Glu Leu Ser Gln Met Gln Ser His Ile Ser Asp 
            340                 345                 350         


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Ser Leu Asp Leu Asp 
        355                 360                 365             


Ser Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Asp Ile Ala Gln Arg 
    370                 375                 380                 


Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys Leu Gly Glu Leu 
385                 390                 395                 400 


Gln Thr Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys Ser 
                405                 410                 415     


Glu Ile Ile Glu Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
            420                 425                 430         


Glu Gly Val Lys Lys Gln Asn Ala Asn Leu Gln Thr Ala Ile Ala Glu 
        435                 440                 445             


Ala Glu Gln His Gly Glu Met Ala Leu Lys Asp Ala Asn Ala Lys Leu 
    450                 455                 460                 


Gln Glu Leu Gln Ala Ala Leu Gln Gln Ala Lys Asp Asp Leu Ala Arg 
465                 470                 475                 480 


Leu Leu Arg Asp Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp 
                485                 490                 495     


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Tyr Arg 
            500                 505                 510         


Met Ser Gly Glu Cys Pro Ser Ala Val Ser Ile Ser Val Val Ser Ser 
        515                 520                 525             


Ser Thr Thr Ser Ala Ser Ala Gly Gly Tyr Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Met Gly Gly Gly Leu Gly Gly Gly Phe Ser Ala Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Ser Gly Phe Gly Arg Gly Gly Gly Gly Gly Ile Gly Gly Gly Phe 
                565                 570                 575     


Gly Gly Gly Ser Ser Gly Phe Ser Gly Gly Ser Gly Phe Gly Ser Ile 
            580                 585                 590         


Ser Gly Ala Arg Tyr Gly Val Ser Gly Gly Gly Phe Ser Ser Ala Ser 
        595                 600                 605             


Asn Arg Gly Gly Ser Ile Lys Phe Ser Gln Ser Ser Gln Ser Ser Gln 
    610                 615                 620                 


Arg Tyr Ser Arg 
625             


<210>  6031
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT4__Homo_sapiens__NP_002263

<400>  6031

Met Ile Ala Arg Gln Gln Cys Val Arg Gly Gly Pro Arg Gly Phe Ser 
1               5                   10                  15      


Cys Gly Ser Ala Ile Val Gly Gly Gly Lys Arg Gly Ala Phe Ser Ser 
            20                  25                  30          


Val Ser Met Ser Gly Gly Ala Gly Arg Cys Ser Ser Gly Gly Phe Gly 
        35                  40                  45              


Ser Arg Ser Leu Tyr Asn Leu Arg Gly Asn Lys Ser Ile Ser Met Ser 
    50                  55                  60                  


Val Ala Gly Ser Arg Gln Gly Ala Cys Phe Gly Gly Ala Gly Gly Phe 
65                  70                  75                  80  


Gly Thr Gly Gly Phe Gly Gly Gly Phe Gly Gly Ser Phe Ser Gly Lys 
                85                  90                  95      


Gly Gly Pro Gly Phe Pro Val Cys Pro Ala Gly Gly Ile Gln Glu Val 
            100                 105                 110         


Thr Ile Asn Gln Ser Leu Leu Thr Pro Leu His Val Glu Ile Asp Pro 
        115                 120                 125             


Glu Ile Gln Lys Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Leu Leu 
    130                 135                 140                 


Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Gln Phe Leu Glu Gln 
145                 150                 155                 160 


Gln Asn Lys Val Leu Glu Thr Lys Trp Asn Leu Leu Gln Gln Gln Thr 
                165                 170                 175     


Thr Thr Thr Ser Ser Lys Asn Leu Glu Pro Leu Phe Glu Thr Tyr Leu 
            180                 185                 190         


Ser Val Leu Arg Lys Gln Leu Asp Thr Leu Gly Asn Asp Lys Gly Arg 
        195                 200                 205             


Leu Gln Ser Glu Leu Lys Thr Met Gln Asp Ser Val Glu Asp Phe Lys 
    210                 215                 220                 


Thr Lys Tyr Glu Glu Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Asp 
225                 230                 235                 240 


Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Leu Asn Lys Val 
                245                 250                 255     


Glu Leu Glu Ala Lys Val Asp Ser Leu Asn Asp Glu Ile Asn Phe Leu 
            260                 265                 270         


Lys Val Leu Tyr Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser 
        275                 280                 285             


Asp Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu 
    290                 295                 300                 


Asp Ser Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Gln 
305                 310                 315                 320 


Arg Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys Val Gln Gln 
                325                 330                 335     


Leu Gln Ile Ser Val Asp Gln His Gly Asp Asn Leu Lys Asn Thr Lys 
            340                 345                 350         


Ser Glu Ile Ala Glu Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu 
        355                 360                 365             


Ile Glu Asn Ile Lys Lys Gln Cys Gln Thr Leu Gln Val Ser Val Ala 
    370                 375                 380                 


Asp Ala Glu Gln Arg Gly Glu Asn Ala Leu Lys Asp Ala His Ser Lys 
385                 390                 395                 400 


Arg Val Glu Leu Glu Ala Ala Leu Gln Gln Ala Lys Glu Glu Leu Ala 
                405                 410                 415     


Arg Met Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala Leu 
            420                 425                 430         


Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Tyr 
        435                 440                 445             


Arg Met Ser Gly Glu Cys Gln Ser Ala Val Ser Ile Ser Val Val Ser 
    450                 455                 460                 


Gly Ser Thr Ser Thr Gly Gly Ile Ser Gly Gly Leu Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Phe Gly Leu Ser Ser Gly Phe Gly Ser Gly Ser Gly Ser Gly Phe 
                485                 490                 495     


Gly Phe Gly Gly Ser Val Ser Gly Ser Ser Ser Ser Lys Ile Ile Ser 
            500                 505                 510         


Thr Thr Thr Leu Asn Lys Arg Arg 
        515                 520 


<210>  6032
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT5__Homo_sapiens__NP_000415

<400>  6032

Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Ser Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210>  6033
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT6A__Homo_sapiens__NP_005545

<400>  6033

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  6034
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT6B__Homo_sapiens__NP_005546

<400>  6034

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Ile Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ala Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Asn Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Asn Met Gln Asp Leu Val Glu Asp Leu Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Ile Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Thr Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  6035
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT6C__Homo_sapiens__NP_775109

<400>  6035

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Ile Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ala Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Asn Met Gln Asp Leu Val Glu Asp Leu Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Ser Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Val Ser Val Val Gln Ser Thr Ile Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Ile Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  6036
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT71__Homo_sapiens__NP_258259

<400>  6036

Met Ser Arg Gln Phe Thr Cys Lys Ser Gly Ala Ala Ala Lys Gly Gly 
1               5                   10                  15      


Phe Ser Gly Cys Ser Ala Val Leu Ser Gly Gly Ser Ser Ser Ser Phe 
            20                  25                  30          


Arg Ala Gly Ser Lys Gly Leu Ser Gly Gly Phe Gly Ser Arg Ser Leu 
        35                  40                  45              


Tyr Ser Leu Gly Gly Val Arg Ser Leu Asn Val Ala Ser Gly Ser Gly 
    50                  55                  60                  


Lys Ser Gly Gly Tyr Gly Phe Gly Arg Gly Arg Ala Ser Gly Phe Ala 
65                  70                  75                  80  


Gly Ser Met Phe Gly Ser Val Ala Leu Gly Pro Val Cys Pro Thr Val 
                85                  90                  95      


Cys Pro Pro Gly Gly Ile His Gln Val Thr Val Asn Glu Ser Leu Leu 
            100                 105                 110         


Ala Pro Leu Asn Val Glu Leu Asp Pro Glu Ile Gln Lys Val Arg Ala 
        115                 120                 125             


Gln Glu Arg Glu Gln Ile Lys Ala Leu Asn Asn Lys Phe Ala Ser Phe 
    130                 135                 140                 


Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu Glu Thr 
145                 150                 155                 160 


Lys Trp Glu Leu Leu Gln Gln Leu Asp Leu Asn Asn Cys Lys Asn Asn 
                165                 170                 175     


Leu Glu Pro Ile Leu Glu Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu 
            180                 185                 190         


Glu Thr Leu Ser Gly Asp Arg Val Arg Leu Asp Ser Glu Leu Arg Asn 
        195                 200                 205             


Val Arg Asp Val Val Glu Asp Tyr Lys Lys Arg Tyr Glu Glu Glu Ile 
    210                 215                 220                 


Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Leu Leu Lys Lys Asp 
225                 230                 235                 240 


Val Asp Ala Ala Tyr Ala Asn Lys Val Glu Leu Gln Ala Lys Val Glu 
                245                 250                 255     


Ser Met Asp Gln Glu Ile Lys Phe Phe Arg Cys Leu Phe Glu Ala Glu 
            260                 265                 270         


Ile Thr Gln Ile Gln Ser His Ile Ser Asp Met Ser Val Ile Leu Ser 
        275                 280                 285             


Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Asp Glu Val 
    290                 295                 300                 


Arg Thr Gln Tyr Glu Glu Ile Ala Leu Lys Ser Lys Ala Glu Ala Glu 
305                 310                 315                 320 


Ala Leu Tyr Gln Thr Lys Phe Gln Glu Leu Gln Leu Ala Ala Gly Arg 
                325                 330                 335     


His Gly Asp Asp Leu Lys Asn Thr Lys Asn Glu Ile Ser Glu Leu Thr 
            340                 345                 350         


Arg Leu Ile Gln Arg Ile Arg Ser Glu Ile Glu Asn Val Lys Lys Gln 
        355                 360                 365             


Ala Ser Asn Leu Glu Thr Ala Ile Ala Asp Ala Glu Gln Arg Gly Asp 
    370                 375                 380                 


Asn Ala Leu Lys Asp Ala Arg Ala Lys Leu Asp Glu Leu Glu Gly Ala 
385                 390                 395                 400 


Leu His Gln Ala Lys Glu Glu Leu Ala Arg Met Leu Arg Glu Tyr Gln 
                405                 410                 415     


Glu Leu Met Ser Leu Lys Leu Ala Leu Asp Met Glu Ile Ala Thr Tyr 
            420                 425                 430         


Arg Lys Leu Leu Glu Ser Glu Glu Cys Arg Met Ser Gly Glu Phe Pro 
        435                 440                 445             


Ser Pro Val Ser Ile Ser Ile Ile Ser Ser Thr Ser Gly Gly Ser Val 
    450                 455                 460                 


Tyr Gly Phe Arg Pro Ser Met Val Ser Gly Gly Tyr Val Ala Asn Ser 
465                 470                 475                 480 


Ser Asn Cys Ile Ser Gly Val Cys Ser Val Arg Gly Gly Glu Gly Arg 
                485                 490                 495     


Ser Arg Gly Ser Ala Asn Asp Tyr Lys Asp Thr Leu Gly Lys Gly Ser 
            500                 505                 510         


Ser Leu Ser Ala Pro Ser Lys Lys Thr Ser Arg 
        515                 520             


<210>  6037
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT72__Homo_sapiens__NP_001139698

<400>  6037

Met Ser Arg Gln Leu Thr His Phe Pro Arg Gly Glu Arg Leu Gly Phe 
1               5                   10                  15      


Ser Gly Cys Ser Ala Val Leu Ser Gly Gly Ile Gly Ser Ser Ser Ala 
            20                  25                  30          


Ser Phe Arg Ala Arg Val Lys Gly Ser Ala Ser Phe Gly Ser Lys Ser 
        35                  40                  45              


Leu Ser Cys Leu Gly Gly Ser Arg Ser Leu Ala Leu Ser Ala Ala Ala 
    50                  55                  60                  


Arg Arg Gly Gly Gly Arg Leu Gly Gly Phe Val Gly Thr Ala Phe Gly 
65                  70                  75                  80  


Ser Ala Gly Leu Gly Pro Lys Cys Pro Ser Val Cys Pro Pro Gly Gly 
                85                  90                  95      


Ile Pro Gln Val Thr Val Asn Lys Ser Leu Leu Ala Pro Leu Asn Val 
            100                 105                 110         


Glu Met Asp Pro Glu Ile Gln Arg Val Arg Ala Gln Glu Arg Glu Gln 
        115                 120                 125             


Ile Lys Ala Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg 
    130                 135                 140                 


Phe Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Asn Leu Leu 
145                 150                 155                 160 


Gln Gln Leu Asp Leu Asn Asn Cys Arg Lys Asn Leu Glu Pro Ile Tyr 
                165                 170                 175     


Glu Gly Tyr Ile Ser Asn Leu Gln Lys Gln Leu Glu Met Leu Ser Gly 
            180                 185                 190         


Asp Gly Val Arg Leu Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val 
        195                 200                 205             


Glu Asp Tyr Lys Lys Arg Tyr Glu Val Glu Ile Asn Arg Arg Thr Ala 
    210                 215                 220                 


Ala Glu Asn Glu Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr 
225                 230                 235                 240 


Met Asn Lys Val Glu Leu Gln Ala Lys Val Asp Ser Leu Thr Asp Glu 
                245                 250                 255     


Ile Lys Phe Phe Lys Cys Leu Tyr Glu Gly Glu Ile Thr Gln Ile Gln 
            260                 265                 270         


Ser His Ile Ser Asp Thr Ser Ile Val Leu Ser Met Asp Asn Asn Arg 
        275                 280                 285             


Asp Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu 
    290                 295                 300                 


Glu Ile Ala Leu Lys Ser Lys Ala Glu Ala Glu Thr Leu Tyr Gln Thr 
305                 310                 315                 320 


Lys Cys Ala Asp Leu Glu Thr Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                325                 330                 335     


Asp Cys Ala Leu Lys Asp Ala Arg Ala Lys Leu Asp Glu Leu Glu Gly 
            340                 345                 350         


Ala Leu His Gln Ala Lys Glu Glu Leu Ala Arg Met Leu Arg Glu Tyr 
        355                 360                 365             


Gln Glu Leu Val Ser Leu Lys Leu Ala Leu Asp Met Glu Ile Ala Thr 
    370                 375                 380                 


Tyr Arg Lys Leu Leu Glu Ser Glu Glu Cys Arg Met Ser Gly Glu Tyr 
385                 390                 395                 400 


Pro Asn Ser Val Ser Ile Ser Val Ile Ser Ser Thr Asn Ala Gly Ala 
                405                 410                 415     


Gly Gly Ala Gly Phe Ser Met Gly Phe Gly Ala Ser Ser Ser Tyr Ser 
            420                 425                 430         


Tyr Lys Thr Ala Ala Ala Asp Val Lys Thr Lys Gly Ser Cys Gly Ser 
        435                 440                 445             


Glu Leu Lys Asp Pro Leu Ala Lys Thr Ser Gly Ser Ser Cys Ala Thr 
    450                 455                 460                 


Lys Lys Ala Ser Arg 
465                 


<210>  6038
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT74__Homo_sapiens__XP_011536204

<400>  6038

Met Ser Arg Gln Leu Asn Ile Lys Ser Ser Gly Asp Lys Gly Asn Phe 
1               5                   10                  15      


Ser Val His Ser Ala Val Val Pro Arg Lys Ala Val Gly Ser Leu Ala 
            20                  25                  30          


Ser Tyr Cys Ala Ala Gly Arg Gly Ala Gly Ala Gly Phe Gly Ser Arg 
        35                  40                  45              


Ser Leu Tyr Ser Leu Gly Gly Asn Arg Arg Ile Ser Phe Asn Val Ala 
    50                  55                  60                  


Gly Gly Gly Val Arg Ala Gly Gly Tyr Gly Phe Arg Pro Gly Ser Gly 
65                  70                  75                  80  


Tyr Gly Gly Gly Arg Ala Ser Gly Phe Ala Gly Ser Met Phe Gly Ser 
                85                  90                  95      


Val Ala Leu Gly Pro Ala Cys Leu Ser Val Cys Pro Pro Gly Gly Ile 
            100                 105                 110         


His Gln Val Thr Val Asn Lys Ser Leu Leu Ala Pro Leu Asn Val Glu 
        115                 120                 125             


Leu Asp Pro Glu Ile Gln Lys Val Arg Ala Gln Glu Arg Glu Gln Ile 
    130                 135                 140                 


Lys Val Leu Asn Asp Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe 
145                 150                 155                 160 


Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Glu Leu Leu Gln 
                165                 170                 175     


Gln Leu Asp Leu Asn Asn Cys Lys Lys Asn Leu Glu Pro Ile Leu Glu 
            180                 185                 190         


Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu Glu Thr Leu Ser Gly Asp 
        195                 200                 205             


Arg Val Arg Leu Asp Ser Glu Leu Arg Ser Met Arg Asp Leu Val Glu 
    210                 215                 220                 


Asp Tyr Lys Lys Arg Tyr Glu Val Glu Ile Asn Arg Arg Thr Thr Ala 
225                 230                 235                 240 


Glu Asn Glu Phe Val Val Leu Lys Lys Asp Ala Asp Ala Ala Tyr Ala 
                245                 250                 255     


Val Lys Val Glu Leu Gln Ala Lys Val Asp Ser Leu Asp Lys Glu Ile 
            260                 265                 270         


Lys Phe Leu Lys Cys Leu Tyr Asp Ala Glu Ile Ala Gln Ile Gln Thr 
        275                 280                 285             


His Ala Ser Glu Thr Ser Val Ile Leu Ser Met Asp Asn Asn Arg Asp 
    290                 295                 300                 


Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Arg Met His Tyr Glu Glu 
305                 310                 315                 320 


Ile Ala Leu Lys Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys 
                325                 330                 335     


Ile Gln Glu Leu Gln Leu Ala Ala Ser Arg His Gly Asp Asp Leu Lys 
            340                 345                 350         


His Thr Arg Ser Glu Met Val Glu Leu Asn Arg Leu Ile Gln Arg Ile 
        355                 360                 365             


Arg Cys Glu Ile Gly Asn Val Lys Lys Gln Arg Ala Ser Leu Glu Thr 
    370                 375                 380                 


Ala Ile Ala Asp Ala Glu Gln Arg Gly Asp Asn Ala Leu Lys Asp Ala 
385                 390                 395                 400 


Gln Ala Lys Leu Asp Glu Leu Glu Gly Ala Leu His Gln Ala Lys Glu 
                405                 410                 415     


Glu Leu Ala Arg Met Leu Arg Glu Tyr Gln Glu Leu Met Ser Leu Lys 
            420                 425                 430         


Leu Ala Leu Asp Met Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly 
        435                 440                 445             


Glu Glu Cys Arg Met Ser Gly Glu Asn Pro Ser Ser Val Ser Ile Ser 
    450                 455                 460                 


Val Ile Ser Ser Ser Ser Tyr Ser Tyr His His Pro Ser Ser Ala Gly 
465                 470                 475                 480 


Val Asp Leu Gly Ala Ser Ala Val Ala Gly Ser Ser Gly Ser Thr Gln 
                485                 490                 495     


Ser Gly Gln Thr Lys Thr Thr Glu Ala Arg Gly Gly Asp Leu Lys Asp 
            500                 505                 510         


Thr Gln Gly Lys Ser Thr Pro Ala Ser Ile Pro Ala Arg Lys Ala Thr 
        515                 520                 525             


Arg 
    


<210>  6039
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT75__Homo_sapiens__NP_004684

<400>  6039

Met Ser Arg Gln Ser Ser Ile Thr Phe Gln Ser Gly Ser Arg Arg Gly 
1               5                   10                  15      


Phe Ser Thr Thr Ser Ala Ile Thr Pro Ala Ala Gly Arg Ser Arg Phe 
            20                  25                  30          


Ser Ser Val Ser Val Ala Arg Ser Ala Ala Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Arg Ile Ser Ser Ala Gly Ala Ser Phe Gly Ser Arg Ser Leu Tyr Asn 
    50                  55                  60                  


Leu Gly Gly Ala Lys Arg Val Ser Ile Asn Gly Cys Gly Ser Ser Cys 
65                  70                  75                  80  


Arg Ser Gly Phe Gly Gly Arg Ala Ser Asn Arg Phe Gly Val Asn Ser 
                85                  90                  95      


Gly Phe Gly Tyr Gly Gly Gly Val Gly Gly Gly Phe Ser Gly Pro Ser 
            100                 105                 110         


Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln 
        115                 120                 125             


Ser Leu Leu Thr Pro Leu His Leu Gln Ile Asp Pro Thr Ile Gln Arg 
    130                 135                 140                 


Val Arg Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe 
145                 150                 155                 160 


Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val 
                165                 170                 175     


Leu Glu Thr Lys Trp Ala Leu Leu Gln Glu Gln Gly Ser Arg Thr Val 
            180                 185                 190         


Arg Gln Asn Leu Glu Pro Leu Phe Asp Ser Tyr Thr Ser Glu Leu Arg 
        195                 200                 205             


Arg Gln Leu Glu Ser Ile Thr Thr Glu Arg Gly Arg Leu Glu Ala Glu 
    210                 215                 220                 


Leu Arg Asn Met Gln Asp Val Val Glu Asp Phe Lys Val Arg Tyr Glu 
225                 230                 235                 240 


Asp Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Ala Leu 
                245                 250                 255     


Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Glu Ala 
            260                 265                 270         


Lys Val Lys Ser Leu Pro Glu Glu Ile Asn Phe Ile His Ser Val Phe 
        275                 280                 285             


Asp Ala Glu Leu Ser Gln Leu Gln Thr Gln Val Gly Asp Thr Ser Val 
    290                 295                 300                 


Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile 
305                 310                 315                 320 


Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn Arg Ser Arg Ala 
                325                 330                 335     


Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr 
            340                 345                 350         


Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ser 
        355                 360                 365             


Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile Asp Ser Val 
    370                 375                 380                 


Lys Lys Gln Cys Ser Ser Leu Gln Thr Ala Ile Ala Asp Ala Glu Gln 
385                 390                 395                 400 


Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Ala Lys Leu Val Asp Leu 
                405                 410                 415     


Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg Leu Leu Arg 
            420                 425                 430         


Glu Tyr Gln Glu Leu Met Asn Ile Lys Leu Ala Leu Asp Val Glu Ile 
        435                 440                 445             


Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Ser Gly 
    450                 455                 460                 


Glu Gly Val Ser Pro Val Asn Ile Ser Val Val Thr Ser Thr Leu Ser 
465                 470                 475                 480 


Ser Gly Tyr Gly Ser Gly Ser Ser Ile Gly Gly Gly Asn Leu Gly Leu 
                485                 490                 495     


Gly Gly Gly Ser Gly Tyr Ser Phe Thr Thr Ser Gly Gly His Ser Leu 
            500                 505                 510         


Gly Ala Gly Leu Gly Gly Ser Gly Phe Ser Ala Thr Ser Asn Arg Gly 
        515                 520                 525             


Leu Gly Gly Ser Gly Ser Ser Val Lys Phe Val Ser Thr Thr Ser Ser 
    530                 535                 540                 


Ser Gln Lys Ser Tyr Thr His 
545                 550     


<210>  6040
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT76__Homo_sapiens__NP_056932

<400>  6040

Met Asn Arg Gln Val Cys Lys Lys Ser Phe Ser Gly Arg Ser Gln Gly 
1               5                   10                  15      


Phe Ser Gly Arg Ser Ala Val Val Ser Gly Ser Ser Arg Met Ser Cys 
            20                  25                  30          


Val Ala Arg Ser Gly Gly Ala Gly Gly Gly Ala Cys Gly Phe Arg Ser 
        35                  40                  45              


Gly Ala Gly Ser Phe Gly Ser Arg Ser Leu Tyr Asn Leu Gly Ser Asn 
    50                  55                  60                  


Lys Ser Ile Ser Ile Ser Val Ala Ala Gly Ser Ser Arg Ala Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Arg Ser Ser Cys Gly Phe Ala Gly Gly Tyr Gly Gly 
                85                  90                  95      


Gly Phe Gly Gly Ser Tyr Gly Gly Gly Phe Gly Gly Gly Arg Gly Val 
            100                 105                 110         


Gly Ser Gly Phe Gly Gly Ala Gly Gly Phe Gly Gly Ala Gly Gly Phe 
        115                 120                 125             


Gly Gly Pro Gly Val Phe Gly Gly Pro Gly Ser Phe Gly Gly Pro Gly 
    130                 135                 140                 


Gly Phe Gly Pro Gly Gly Phe Pro Gly Gly Ile Gln Glu Val Ile Val 
145                 150                 155                 160 


Asn Gln Ser Leu Leu Gln Pro Leu Asn Val Glu Ile Asp Pro Gln Ile 
                165                 170                 175     


Gly Gln Val Lys Ala Gln Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn 
            180                 185                 190         


Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        195                 200                 205             


Lys Val Leu Glu Thr Lys Trp Glu Leu Leu Gln Gln Gln Thr Thr Gly 
    210                 215                 220                 


Ser Gly Pro Ser Ser Leu Glu Pro Cys Phe Glu Ser Tyr Ile Ser Phe 
225                 230                 235                 240 


Leu Cys Lys Gln Leu Asp Ser Leu Leu Gly Glu Arg Gly Asn Leu Glu 
                245                 250                 255     


Gly Glu Leu Lys Ser Met Gln Asp Leu Val Glu Asp Phe Lys Lys Lys 
            260                 265                 270         


Tyr Glu Asp Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val 
        275                 280                 285             


Gly Leu Lys Lys Asp Val Asp Ala Ala Phe Met Asn Lys Val Glu Leu 
    290                 295                 300                 


Gln Ala Lys Val Asp Ser Leu Thr Asp Glu Val Ser Phe Leu Arg Thr 
305                 310                 315                 320 


Leu Tyr Glu Met Glu Leu Ser Gln Met Gln Ser His Ala Ser Asp Thr 
                325                 330                 335     


Ser Val Val Leu Ser Met Asp Asn Asn Arg Cys Leu Asp Leu Gly Ser 
            340                 345                 350         


Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser 
        355                 360                 365             


Lys Ser Glu Ala Glu Ala Leu Tyr Gln Thr Lys Leu Gly Glu Leu Gln 
    370                 375                 380                 


Thr Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys Ser Glu 
385                 390                 395                 400 


Ile Met Glu Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile Glu 
                405                 410                 415     


Asn Val Lys Lys Gln Asn Ala Asn Leu Gln Thr Ala Ile Ala Glu Ala 
            420                 425                 430         


Glu Gln Arg Gly Glu Met Ala Leu Lys Asp Ala Asn Ala Lys Leu Gln 
        435                 440                 445             


Asp Leu Gln Thr Ala Leu Gln Lys Ala Lys Asp Asp Leu Ala Arg Leu 
    450                 455                 460                 


Leu Arg Asp Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val 
465                 470                 475                 480 


Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Met 
                485                 490                 495     


Ser Gly Glu Cys Gln Ser Ala Val Cys Ile Ser Val Val Ser Asn Val 
            500                 505                 510         


Thr Ser Thr Ser Gly Ser Ser Gly Ser Ser Arg Gly Val Phe Gly Gly 
        515                 520                 525             


Val Ser Gly Ser Gly Ser Gly Gly Tyr Lys Gly Gly Ser Ser Ser Ser 
    530                 535                 540                 


Ser Ser Ser Gly Tyr Gly Val Ser Gly Gly Ser Gly Ser Gly Tyr Gly 
545                 550                 555                 560 


Gly Val Ser Ser Gly Ser Thr Gly Gly Arg Gly Ser Ser Gly Ser Tyr 
                565                 570                 575     


Gln Ser Ser Ser Ser Gly Ser Arg Leu Gly Gly Ala Gly Ser Ile Ser 
            580                 585                 590         


Val Ser His Ser Gly Met Gly Ser Ser Ser Gly Ser Ile Gln Thr Ser 
        595                 600                 605             


Gly Gly Ser Gly Tyr Lys Ser Gly Gly Gly Gly Ser Thr Ser Ile Arg 
    610                 615                 620                 


Phe Ser Gln Thr Thr Ser Ser Ser Gln His Ser Ser Thr Lys 
625                 630                 635             


<210>  6041
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT78__Homo_sapiens__NP_001287743

<400>  6041

Met Glu Gly His Glu Ala Ser Pro Ala Gln Val Gly Gln Gly Asp Arg 
1               5                   10                  15      


Gly Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu Thr Lys 
            20                  25                  30          


Trp His Leu Leu Gln Gln Gln Gly Leu Ser Gly Ser Gln Gln Gly Leu 
        35                  40                  45              


Glu Pro Val Phe Glu Ala Cys Leu Asp Gln Leu Arg Lys Gln Leu Glu 
    50                  55                  60                  


Gln Leu Gln Gly Glu Arg Gly Ala Leu Asp Ala Glu Leu Lys Ala Cys 
65                  70                  75                  80  


Arg Asp Gln Glu Glu Glu Tyr Lys Ser Lys Tyr Glu Glu Glu Ala His 
                85                  90                  95      


Arg Arg Ala Thr Leu Glu Asn Asp Phe Val Val Leu Lys Lys Asp Val 
            100                 105                 110         


Asp Gly Val Phe Leu Ser Lys Met Glu Leu Glu Gly Lys Leu Glu Ala 
        115                 120                 125             


Leu Arg Glu Tyr Leu Tyr Phe Leu Lys His Leu Asn Glu Glu Glu Leu 
    130                 135                 140                 


Gly Gln Leu Gln Thr Gln Ala Ser Asp Thr Ser Val Val Leu Ser Met 
145                 150                 155                 160 


Asp Asn Asn Arg Tyr Leu Asp Phe Ser Ser Ile Ile Thr Glu Val Arg 
                165                 170                 175     


Ala Arg Tyr Glu Glu Ile Ala Arg Ser Ser Lys Ala Glu Ala Glu Ala 
            180                 185                 190         


Leu Tyr Gln Thr Lys Tyr Gln Glu Leu Gln Val Ser Ala Gln Leu His 
        195                 200                 205             


Gly Asp Arg Met Gln Glu Thr Lys Val Gln Ile Ser Gln Leu His Gln 
    210                 215                 220                 


Glu Ile Gln Arg Leu Gln Ser Gln Thr Glu Asn Leu Lys Lys Gln Asn 
225                 230                 235                 240 


Ala Ser Leu Gln Ala Ala Ile Thr Asp Ala Glu Gln Arg Gly Glu Leu 
                245                 250                 255     


Ala Leu Lys Asp Ala Gln Ala Lys Val Asp Glu Leu Glu Ala Ala Leu 
            260                 265                 270         


Arg Met Ala Lys Gln Asn Leu Ala Arg Leu Leu Cys Glu Tyr Gln Glu 
        275                 280                 285             


Leu Thr Ser Thr Lys Leu Ser Leu Asp Val Glu Ile Ala Thr Tyr Arg 
    290                 295                 300                 


Arg Leu Leu Glu Gly Glu Glu Cys Arg Met Ser Gly Glu Cys Thr Ser 
305                 310                 315                 320 


Gln Val Thr Ile Ser Ser Val Gly Gly Ser Ala Val Met Ser Gly Gly 
                325                 330                 335     


Val Gly Gly Gly Leu Gly Ser Thr Cys Gly Leu Gly Ser Gly Lys Gly 
            340                 345                 350         


Ser Pro Gly Ser Cys Cys Thr Ser Ile Val Thr Gly Gly Ser Asn Ile 
        355                 360                 365             


Ile Leu Gly Ser Gly Lys Asp Pro Val Leu Asp Ser Cys Ser Val Ser 
    370                 375                 380                 


Gly Ser Ser Ala Gly Ser Ser Cys His Thr Ile Leu Lys Lys Thr Val 
385                 390                 395                 400 


Glu Ser Ser Leu Lys Thr Ser Ile Thr Tyr 
                405                 410 


<210>  6042
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT7__Homo_sapiens__NP_005547

<400>  6042

Met Ser Ile His Phe Ser Ser Pro Val Phe Thr Ser Arg Ser Ala Ala 
1               5                   10                  15      


Phe Ser Gly Arg Gly Ala Gln Val Arg Leu Ser Ser Ala Arg Pro Gly 
            20                  25                  30          


Gly Leu Gly Ser Ser Ser Leu Tyr Gly Leu Gly Ala Ser Arg Pro Arg 
        35                  40                  45              


Val Ala Val Arg Ser Ala Tyr Gly Gly Pro Val Gly Ala Gly Ile Arg 
    50                  55                  60                  


Glu Val Thr Ile Asn Gln Ser Leu Leu Ala Pro Leu Arg Leu Asp Ala 
65                  70                  75                  80  


Asp Pro Ser Leu Gln Arg Val Arg Gln Glu Glu Ser Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Leu Leu Glu Thr Lys Trp Thr Leu Leu Gln Glu 
        115                 120                 125             


Gln Lys Ser Ala Lys Ser Ser Arg Leu Pro Asp Ile Phe Glu Ala Gln 
    130                 135                 140                 


Ile Ala Gly Leu Arg Gly Gln Leu Glu Ala Leu Gln Val Asp Gly Gly 
145                 150                 155                 160 


Arg Leu Glu Ala Glu Leu Arg Ser Met Gln Asp Val Val Glu Asp Phe 
                165                 170                 175     


Lys Asn Lys Tyr Glu Asp Glu Ile Asn His Arg Thr Ala Ala Glu Asn 
            180                 185                 190         


Glu Phe Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Ser Lys 
        195                 200                 205             


Val Glu Leu Glu Ala Lys Val Asp Ala Leu Asn Asp Glu Ile Asn Phe 
    210                 215                 220                 


Leu Arg Thr Leu Asn Glu Thr Glu Leu Thr Glu Leu Gln Ser Gln Ile 
225                 230                 235                 240 


Ser Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp 
                245                 250                 255     


Leu Asp Gly Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Met Ala 
            260                 265                 270         


Lys Cys Ser Arg Ala Glu Ala Glu Ala Trp Tyr Gln Thr Lys Phe Glu 
        275                 280                 285             


Thr Leu Gln Ala Gln Ala Gly Lys His Gly Asp Asp Leu Arg Asn Thr 
    290                 295                 300                 


Arg Asn Glu Ile Ser Glu Met Asn Arg Ala Ile Gln Arg Leu Gln Ala 
305                 310                 315                 320 


Glu Ile Asp Asn Ile Lys Asn Gln Arg Ala Lys Leu Glu Ala Ala Ile 
                325                 330                 335     


Ala Glu Ala Glu Glu Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Ala 
            340                 345                 350         


Lys Gln Glu Glu Leu Glu Ala Ala Leu Gln Arg Gly Lys Gln Asp Met 
        355                 360                 365             


Ala Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala 
    370                 375                 380                 


Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
385                 390                 395                 400 


Ser Arg Leu Ala Gly Asp Gly Val Gly Ala Val Asn Ile Ser Val Met 
                405                 410                 415     


Asn Ser Thr Gly Gly Ser Ser Ser Gly Gly Gly Ile Gly Leu Thr Leu 
            420                 425                 430         


Gly Gly Thr Met Gly Ser Asn Ala Leu Ser Phe Ser Ser Ser Ala Gly 
        435                 440                 445             


Pro Gly Leu Leu Lys Ala Tyr Ser Ile Arg Thr Ala Ser Ala Ser Arg 
    450                 455                 460                 


Arg Ser Ala Arg Asp 
465                 


<210>  6043
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT80__Homo_sapiens__NP_001074961

<400>  6043

Met Ala Cys Arg Ser Cys Val Val Gly Phe Ser Ser Leu Ser Ser Cys 
1               5                   10                  15      


Glu Val Thr Pro Val Gly Ser Pro Arg Pro Gly Thr Ser Gly Trp Asp 
            20                  25                  30          


Ser Cys Arg Ala Pro Gly Pro Gly Phe Ser Ser Arg Ser Leu Thr Gly 
        35                  40                  45              


Cys Trp Ser Ala Gly Thr Ile Ser Lys Val Thr Val Asn Pro Gly Leu 
    50                  55                  60                  


Leu Val Pro Leu Asp Val Lys Leu Asp Pro Ala Val Gln Gln Leu Lys 
65                  70                  75                  80  


Asn Gln Glu Lys Glu Glu Met Lys Ala Leu Asn Asp Lys Phe Ala Ser 
                85                  90                  95      


Leu Ile Gly Lys Val Gln Ala Leu Glu Gln Arg Asn Gln Leu Leu Glu 
            100                 105                 110         


Thr Arg Trp Ser Phe Leu Gln Gly Gln Asp Ser Ala Ile Phe Asp Leu 
        115                 120                 125             


Gly His Leu Tyr Glu Glu Tyr Gln Gly Arg Leu Gln Glu Glu Leu Arg 
    130                 135                 140                 


Lys Val Ser Gln Glu Arg Gly Gln Leu Glu Ala Asn Leu Leu Gln Val 
145                 150                 155                 160 


Leu Glu Lys Val Glu Glu Phe Arg Ile Arg Tyr Glu Asp Glu Ile Ser 
                165                 170                 175     


Lys Arg Thr Asp Met Glu Phe Thr Phe Val Gln Leu Lys Lys Asp Leu 
            180                 185                 190         


Asp Ala Glu Cys Leu His Arg Thr Glu Leu Glu Thr Lys Leu Lys Ser 
        195                 200                 205             


Leu Glu Ser Phe Val Glu Leu Met Lys Thr Ile Tyr Glu Gln Glu Leu 
    210                 215                 220                 


Lys Asp Leu Ala Ala Gln Val Lys Asp Val Ser Val Thr Val Gly Met 
225                 230                 235                 240 


Asp Ser Arg Cys His Ile Asp Leu Ser Gly Ile Val Glu Glu Val Lys 
                245                 250                 255     


Ala Gln Tyr Asp Ala Val Ala Ala Arg Ser Leu Glu Glu Ala Glu Ala 
            260                 265                 270         


Tyr Ser Arg Ser Gln Leu Glu Glu Gln Ala Ala Arg Ser Ala Glu Tyr 
        275                 280                 285             


Gly Ser Ser Leu Gln Ser Ser Arg Ser Glu Ile Ala Asp Leu Asn Val 
    290                 295                 300                 


Arg Ile Gln Lys Leu Arg Ser Gln Ile Leu Ser Val Lys Ser His Cys 
305                 310                 315                 320 


Leu Lys Leu Glu Glu Asn Ile Lys Thr Ala Glu Glu Gln Gly Glu Leu 
                325                 330                 335     


Ala Phe Gln Asp Ala Lys Thr Lys Leu Ala Gln Leu Glu Ala Ala Leu 
            340                 345                 350         


Gln Gln Ala Lys Gln Asp Met Ala Arg Gln Leu Arg Lys Tyr Gln Glu 
        355                 360                 365             


Leu Met Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg 
    370                 375                 380                 


Lys Leu Val Glu Gly Glu Glu Gly Arg Met Asp Ser Pro Ser Ala Thr 
385                 390                 395                 400 


Val Val Ser Ala Val Gln Ser Arg Cys Lys Thr Ala Pro Ser Leu Pro 
                405                 410                 415     


Tyr Pro Leu Cys Ser Leu 
            420         


<210>  6044
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT81__Homo_sapiens__XP_011536636

<400>  6044

Met Thr Cys Gly Ser Gly Phe Gly Gly Arg Ala Phe Ser Cys Ile Ser 
1               5                   10                  15      


Ala Cys Gly Pro Arg Pro Gly Arg Cys Cys Ile Thr Ala Ala Pro Tyr 
            20                  25                  30          


Arg Gly Ile Ser Cys Tyr Arg Gly Leu Thr Gly Gly Phe Gly Ser His 
        35                  40                  45              


Ser Val Cys Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe Gly 
    50                  55                  60                  


Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr Thr 
65                  70                  75                  80  


Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp 
                85                  90                  95      


Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys Ser 
            100                 105                 110         


Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu Glu 
        115                 120                 125             


Gln Gln Asn Lys Leu Leu Glu Thr Lys Leu Gln Phe Tyr Gln Asn Arg 
    130                 135                 140                 


Glu Cys Cys Gln Ser Asn Leu Glu Pro Leu Phe Glu Gly Tyr Ile Glu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg Leu 
                165                 170                 175     


Ala Ser Glu Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys Lys 
            180                 185                 190         


Lys Tyr Glu Glu Glu Val Ser Leu Arg Ala Thr Ala Glu Asn Glu Phe 
        195                 200                 205             


Val Ala Leu Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp 
    210                 215                 220                 


Leu Glu Ala Asn Val Glu Ala Leu Ile Gln Glu Ile Asp Phe Leu Arg 
225                 230                 235                 240 


Arg Leu Tyr Glu Glu Glu Ile Leu Ile Leu Gln Ser His Ile Ser Asp 
                245                 250                 255     


Thr Ser Val Val Val Lys Leu Asp Asn Ser Arg Asp Leu Asn Met Asp 
            260                 265                 270         


Cys Ile Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Val Thr Arg 
        275                 280                 285             


Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met 
    290                 295                 300                 


Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu 
305                 310                 315                 320 


Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Val 
                325                 330                 335     


Glu Asn Ala Lys Cys Gln Asn Ser Lys Leu Glu Ala Ala Val Ala Gln 
            340                 345                 350         


Ser Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu 
        355                 360                 365             


Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys 
    370                 375                 380                 


Leu Ile Arg Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp 
385                 390                 395                 400 


Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu Gln Arg 
                405                 410                 415     


Leu Cys Glu Gly Ile Gly Ala Val Asn Val Cys Val Ser Ser Ser Arg 
            420                 425                 430         


Gly Gly Val Val Cys Gly Asp Leu Cys Val Ser Gly Ser Arg Pro Val 
        435                 440                 445             


Thr Gly Ser Val Cys Ser Ala Pro Cys Asn Gly Asn Val Ala Val Ser 
    450                 455                 460                 


Thr Gly Leu Cys Ala Pro Cys Gly Gln Leu Asn Thr Thr Cys Gly Gly 
465                 470                 475                 480 


Gly Ser Cys Gly Val Gly Ser Cys Gly Ile Ser Ser Leu Gly Val Gly 
                485                 490                 495     


Ser Cys Gly Ser Ser Cys Arg Lys Cys 
            500                 505 


<210>  6045
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT82__Homo_sapiens__NP_149022

<400>  6045

Met Ser Tyr His Ser Phe Gln Pro Gly Ser Arg Cys Gly Ser Gln Ser 
1               5                   10                  15      


Phe Ser Ser Tyr Ser Ala Val Met Pro Arg Met Val Thr His Tyr Ala 
            20                  25                  30          


Val Ser Lys Gly Pro Cys Arg Pro Gly Gly Gly Arg Gly Leu Arg Ala 
        35                  40                  45              


Leu Gly Cys Leu Gly Ser Arg Ser Leu Cys Asn Val Gly Phe Gly Arg 
    50                  55                  60                  


Pro Arg Val Ala Ser Arg Cys Gly Gly Thr Leu Pro Gly Phe Gly Tyr 
65                  70                  75                  80  


Arg Leu Gly Ala Thr Cys Gly Pro Ser Ala Cys Ile Thr Pro Val Thr 
                85                  90                  95      


Ile Asn Glu Ser Leu Leu Val Pro Leu Ala Leu Glu Ile Asp Pro Thr 
            100                 105                 110         


Val Gln Arg Val Lys Arg Asp Glu Lys Glu Gln Ile Lys Cys Leu Asn 
        115                 120                 125             


Asn Arg Phe Ala Ser Phe Ile Asn Lys Val Arg Phe Leu Glu Gln Lys 
    130                 135                 140                 


Asn Lys Leu Leu Glu Thr Lys Trp Asn Phe Met Gln Gln Gln Arg Cys 
145                 150                 155                 160 


Cys Gln Thr Asn Ile Glu Pro Ile Phe Glu Gly Tyr Ile Ser Ala Leu 
                165                 170                 175     


Arg Arg Gln Leu Asp Cys Val Ser Gly Asp Arg Val Arg Leu Glu Ser 
            180                 185                 190         


Glu Leu Cys Ser Leu Gln Ala Ala Leu Glu Gly Tyr Lys Lys Lys Tyr 
        195                 200                 205             


Glu Glu Glu Leu Ser Leu Arg Pro Cys Val Glu Asn Glu Phe Val Ala 
    210                 215                 220                 


Leu Lys Lys Asp Val Asp Thr Ala Phe Leu Met Lys Ala Asp Leu Glu 
225                 230                 235                 240 


Thr Asn Ala Glu Ala Leu Val Gln Glu Ile Asp Phe Leu Lys Ser Leu 
                245                 250                 255     


Tyr Glu Glu Glu Ile Cys Leu Leu Gln Ser Gln Ile Ser Glu Thr Ser 
            260                 265                 270         


Val Ile Val Lys Met Asp Asn Ser Arg Glu Leu Asp Val Asp Gly Ile 
        275                 280                 285             


Ile Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Ala Ser Arg Ser Lys 
    290                 295                 300                 


Ala Glu Ala Glu Ala Trp Tyr Gln Cys Arg Tyr Glu Glu Leu Arg Val 
305                 310                 315                 320 


Thr Ala Gly Asn His Cys Asp Asn Leu Arg Asn Arg Lys Asn Glu Ile 
                325                 330                 335     


Leu Glu Met Asn Lys Leu Ile Gln Arg Leu Gln Gln Glu Thr Glu Asn 
            340                 345                 350         


Val Lys Ala Gln Arg Cys Lys Leu Glu Gly Ala Ile Ala Glu Ala Glu 
        355                 360                 365             


Gln Gln Gly Glu Ala Ala Leu Asn Asp Ala Lys Cys Lys Leu Ala Gly 
    370                 375                 380                 


Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys Leu Leu 
385                 390                 395                 400 


Lys Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp Ile Glu 
                405                 410                 415     


Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu His Arg Leu Cys 
            420                 425                 430         


Glu Gly Ile Gly Pro Val Asn Ile Ser Val Ser Ser Ser Lys Gly Ala 
        435                 440                 445             


Phe Leu Tyr Glu Pro Cys Gly Val Ser Thr Pro Val Leu Ser Thr Gly 
    450                 455                 460                 


Val Leu Arg Ser Asn Gly Gly Cys Ser Ile Val Gly Thr Gly Glu Leu 
465                 470                 475                 480 


Tyr Val Pro Cys Glu Pro Gln Gly Leu Leu Ser Cys Gly Ser Gly Arg 
                485                 490                 495     


Lys Ser Ser Met Thr Leu Gly Ala Gly Gly Ser Ser Pro Ser His Lys 
            500                 505                 510         


His 
    


<210>  6046
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT83__Homo_sapiens__NP_002273

<400>  6046

Met Thr Cys Gly Phe Asn Ser Ile Gly Cys Gly Phe Arg Pro Gly Asn 
1               5                   10                  15      


Phe Ser Cys Val Ser Ala Cys Gly Pro Arg Pro Ser Arg Cys Cys Ile 
            20                  25                  30          


Thr Ala Ala Pro Tyr Arg Gly Ile Ser Cys Tyr Arg Gly Leu Thr Gly 
        35                  40                  45              


Gly Phe Gly Ser His Ser Val Cys Gly Gly Phe Arg Ala Gly Ser Cys 
    50                  55                  60                  


Gly Arg Ser Phe Gly Tyr Arg Ser Gly Gly Val Cys Gly Pro Ser Pro 
65                  70                  75                  80  


Pro Cys Ile Thr Thr Val Ser Val Asn Glu Ser Leu Leu Thr Pro Leu 
                85                  90                  95      


Asn Leu Glu Ile Asp Pro Asn Ala Gln Cys Val Lys Gln Glu Glu Lys 
            100                 105                 110         


Glu Gln Ile Lys Ser Leu Asn Ser Arg Phe Ala Ala Phe Ile Asp Lys 
        115                 120                 125             


Val Arg Phe Leu Glu Gln Gln Asn Lys Leu Leu Glu Thr Lys Leu Gln 
    130                 135                 140                 


Phe Tyr Gln Asn Arg Glu Cys Cys Gln Ser Asn Leu Glu Pro Leu Phe 
145                 150                 155                 160 


Ala Gly Tyr Ile Glu Thr Leu Arg Arg Glu Ala Glu Cys Val Glu Ala 
                165                 170                 175     


Asp Ser Gly Arg Leu Ala Ser Glu Leu Asn His Val Gln Glu Val Leu 
            180                 185                 190         


Glu Gly Tyr Lys Lys Lys Tyr Glu Glu Glu Val Ala Leu Arg Ala Thr 
        195                 200                 205             


Ala Glu Asn Glu Phe Val Ala Leu Lys Lys Asp Val Asp Cys Ala Tyr 
    210                 215                 220                 


Leu Arg Lys Ser Asp Leu Glu Ala Asn Val Glu Ala Leu Ile Gln Glu 
225                 230                 235                 240 


Ile Asp Phe Leu Arg Arg Leu Tyr Glu Glu Glu Ile Arg Ile Leu Gln 
                245                 250                 255     


Ser His Ile Ser Asp Thr Ser Val Val Val Lys Leu Asp Asn Ser Arg 
            260                 265                 270         


Asp Leu Asn Met Asp Cys Ile Val Ala Glu Ile Lys Ala Gln Tyr Asp 
        275                 280                 285             


Asp Ile Ala Thr Arg Ser Arg Ala Glu Ala Glu Ser Trp Tyr Arg Ser 
    290                 295                 300                 


Lys Cys Glu Glu Met Lys Ala Thr Val Ile Arg His Gly Glu Thr Leu 
305                 310                 315                 320 


Arg Arg Thr Lys Glu Glu Ile Asn Glu Leu Asn Arg Met Ile Gln Arg 
                325                 330                 335     


Leu Thr Ala Glu Val Glu Asn Ala Lys Cys Gln Asn Ser Lys Leu Glu 
            340                 345                 350         


Ala Ala Val Ala Gln Ser Glu Gln Gln Gly Glu Ala Ala Leu Ser Asp 
        355                 360                 365             


Ala Arg Cys Lys Leu Ala Glu Leu Glu Gly Ala Leu Gln Lys Ala Lys 
    370                 375                 380                 


Gln Asp Met Ala Cys Leu Ile Arg Glu Tyr Gln Glu Val Met Asn Ser 
385                 390                 395                 400 


Lys Leu Gly Leu Asp Ile Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu 
                405                 410                 415     


Gly Glu Glu Gln Arg Leu Cys Glu Gly Val Glu Ala Val Asn Val Cys 
            420                 425                 430         


Val Ser Ser Ser Arg Gly Gly Val Val Cys Gly Asp Leu Cys Val Ser 
        435                 440                 445             


Gly Ser Arg Pro Val Thr Gly Ser Val Cys Ser Ala Pro Cys Asn Gly 
    450                 455                 460                 


Asn Leu Val Val Ser Thr Gly Leu Cys Lys Pro Cys Gly Gln Leu Asn 
465                 470                 475                 480 


Thr Thr Cys Gly Gly Gly Ser Cys Gly Gln Gly Arg His 
                485                 490             


<210>  6047
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT85__Homo_sapiens__NP_001287739

<400>  6047

Met Val Phe Lys Val Gln Phe Leu Ser Ser Arg Pro Ser Leu Ser His 
1               5                   10                  15      


Thr Gln Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp Leu Glu Ala 
            20                  25                  30          


Asn Val Glu Ala Leu Val Glu Glu Ser Ser Phe Leu Arg Arg Leu Tyr 
        35                  40                  45              


Glu Glu Glu Ile Arg Val Leu Gln Ala His Ile Ser Asp Thr Ser Val 
    50                  55                  60                  


Ile Val Lys Met Asp Asn Ser Arg Asp Leu Asn Met Asp Cys Ile Ile 
65                  70                  75                  80  


Ala Glu Ile Lys Ala Gln Tyr Asp Asp Val Ala Ser Arg Ser Arg Ala 
                85                  90                  95      


Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met Lys Ala Thr 
            100                 105                 110         


Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu Glu Ile Asn 
        115                 120                 125             


Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Ile Glu Asn Ala 
    130                 135                 140                 


Lys Cys Gln Arg Ala Lys Leu Glu Ala Ala Val Ala Glu Ala Glu Gln 
145                 150                 155                 160 


Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu Ala Glu Leu 
                165                 170                 175     


Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys Leu Leu Lys 
            180                 185                 190         


Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp Ile Glu Ile 
        195                 200                 205             


Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu His Arg Leu Cys Glu 
    210                 215                 220                 


Gly Val Gly Ser Val Asn Val Cys Val Ser Ser Ser Arg Gly Gly Val 
225                 230                 235                 240 


Ser Cys Gly Gly Leu Ser Tyr Ser Thr Thr Pro Gly Arg Gln Ile Thr 
                245                 250                 255     


Ser Gly Pro Ser Ala Ile Gly Gly Ser Ile Thr Val Val Ala Pro Asp 
            260                 265                 270         


Ser Cys Ala Pro Cys Gln Pro Arg Ser Ser Ser Phe Ser Cys Gly Ser 
        275                 280                 285             


Ser Arg Ser Val Arg Phe Ala 
    290                 295 


<210>  6048
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT86__Homo_sapiens__XP_005268923

<400>  6048

Met Cys Glu Glu Leu Lys Ala Thr Val Gln Lys His Thr Gln Ser Leu 
1               5                   10                  15      


Lys Pro Ser Lys Glu Asp Leu Asn Arg Leu Asn Gln Ala Ile Gln Trp 
            20                  25                  30          


Leu Thr Val Glu Val Gly Ser Ala Glu Ser Gln Ala Tyr Arg Gly Ala 
        35                  40                  45              


Ser Ser Glu Arg Leu Thr Pro Arg Pro Leu Cys Ser Pro Phe Gly Arg 
    50                  55                  60                  


Leu His Pro Gln Asn Leu Leu Ser Ser Pro Lys Ser Thr Met Thr Cys 
65                  70                  75                  80  


Gly Ser Tyr Cys Gly Gly Arg Ala Phe Ser Cys Ile Ser Ala Cys Gly 
                85                  90                  95      


Pro Arg Pro Gly Arg Cys Cys Ile Thr Ala Ala Pro Tyr Arg Gly Ile 
            100                 105                 110         


Ser Cys Tyr Arg Gly Leu Thr Gly Gly Phe Gly Ser His Ser Val Cys 
        115                 120                 125             


Gly Gly Phe Arg Ala Gly Ser Cys Gly Arg Ser Phe Gly Tyr Arg Ser 
    130                 135                 140                 


Gly Gly Val Cys Gly Pro Ser Pro Pro Cys Ile Thr Thr Val Ser Val 
145                 150                 155                 160 


Asn Glu Ser Leu Leu Thr Pro Leu Asn Leu Glu Ile Asp Pro Asn Ala 
                165                 170                 175     


Gln Cys Val Lys Gln Glu Glu Lys Glu Gln Ile Lys Ser Leu Asn Ser 
            180                 185                 190         


Arg Phe Ala Ala Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        195                 200                 205             


Lys Leu Leu Glu Thr Lys Leu Gln Phe Tyr Gln Asn Arg Glu Cys Cys 
    210                 215                 220                 


Gln Ser Asn Leu Glu Pro Leu Phe Glu Gly Tyr Ile Glu Thr Leu Arg 
225                 230                 235                 240 


Arg Glu Ala Glu Cys Val Glu Ala Asp Ser Gly Arg Leu Ala Ser Glu 
                245                 250                 255     


Leu Asn His Val Gln Glu Val Leu Glu Gly Tyr Lys Lys Lys Tyr Glu 
            260                 265                 270         


Glu Glu Val Ser Leu Arg Ala Thr Ala Glu Asn Glu Phe Val Ala Leu 
        275                 280                 285             


Lys Lys Asp Val Asp Cys Ala Tyr Leu Arg Lys Ser Asp Leu Glu Ala 
    290                 295                 300                 


Asn Val Glu Ala Leu Ile Gln Glu Ile Asp Phe Leu Arg Arg Leu Tyr 
305                 310                 315                 320 


Glu Glu Glu Ile Arg Val Leu Gln Ser His Ile Ser Asp Thr Ser Val 
                325                 330                 335     


Val Val Lys Leu Asp Asn Ser Arg Asp Leu Asn Met Asp Cys Ile Ile 
            340                 345                 350         


Ala Glu Ile Lys Ala Gln Tyr Asp Asp Ile Val Thr Arg Ser Arg Ala 
        355                 360                 365             


Glu Ala Glu Ser Trp Tyr Arg Ser Lys Cys Glu Glu Met Lys Ala Thr 
    370                 375                 380                 


Val Ile Arg His Gly Glu Thr Leu Arg Arg Thr Lys Glu Glu Ile Asn 
385                 390                 395                 400 


Glu Leu Asn Arg Met Ile Gln Arg Leu Thr Ala Glu Val Glu Asn Ala 
                405                 410                 415     


Lys Cys Gln Asn Ser Lys Leu Glu Ala Ala Val Ala Gln Ser Glu Gln 
            420                 425                 430         


Gln Gly Glu Ala Ala Leu Ser Asp Ala Arg Cys Lys Leu Ala Glu Leu 
        435                 440                 445             


Glu Gly Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Cys Leu Ile Arg 
    450                 455                 460                 


Glu Tyr Gln Glu Val Met Asn Ser Lys Leu Gly Leu Asp Ile Glu Ile 
465                 470                 475                 480 


Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu Glu Gln Arg Leu Cys Glu 
                485                 490                 495     


Gly Val Gly Ser Val Asn Val Cys Val Ser Ser Ser Arg Gly Gly Val 
            500                 505                 510         


Val Cys Gly Asp Leu Cys Ala Ser Thr Thr Ala Pro Val Val Ser Thr 
        515                 520                 525             


Arg Val Ser Ser Val Pro Ser Asn Ser Asn Val Val Val Gly Thr Thr 
    530                 535                 540                 


Asn Ala Cys Ala Pro Ser Ala Arg Val Gly Val Cys Gly Gly Ser Cys 
545                 550                 555                 560 


Lys Arg Cys 
            


<210>  6049
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT8__Homo_sapiens__NP_001243211

<400>  6049

Met Asn Gly Val Ser Trp Ser Gln Asp Leu Gln Glu Gly Ile Ser Ala 
1               5                   10                  15      


Trp Phe Gly Pro Pro Ala Ser Thr Pro Ala Ser Thr Met Ser Ile Arg 
            20                  25                  30          


Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly Pro Arg Ala Phe 
        35                  40                  45              


Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg Ile Ser Ser Ser 
    50                  55                  60                  


Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly Gly Leu Gly Gly 
65                  70                  75                  80  


Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr Ala Val Thr Val 
                85                  90                  95      


Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val Asp Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys Thr Leu Asn Asn 
        115                 120                 125             


Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
    130                 135                 140                 


Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln Gln Lys Thr Ala 
145                 150                 155                 160 


Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile Asn Asn Leu Arg 
                165                 170                 175     


Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys Leu Glu Ala Glu 
            180                 185                 190         


Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu 
        195                 200                 205             


Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu Phe Val Leu Ile 
    210                 215                 220                 


Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val Glu Leu Glu Ser 
225                 230                 235                 240 


Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu Arg Gln Leu Tyr 
                245                 250                 255     


Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser Asp Thr Ser Val 
            260                 265                 270         


Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met Asp Ser Ile Ile 
        275                 280                 285             


Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn Arg Ser Arg Ala 
    290                 295                 300                 


Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu Leu Gln Ser Leu 
305                 310                 315                 320 


Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys Thr Glu Ile Ser 
                325                 330                 335     


Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu Ile Glu Gly Leu 
            340                 345                 350         


Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala Asp Ala Glu Gln 
        355                 360                 365             


Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu 
    370                 375                 380                 


Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala Arg Gln Leu Arg 
385                 390                 395                 400 


Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Ile Glu Ile 
                405                 410                 415     


Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Leu Glu Ser 
            420                 425                 430         


Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr Ser Gly Tyr Ala 
        435                 440                 445             


Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser Pro Gly Leu Ser 
    450                 455                 460                 


Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly Ser Ser Ser Phe 
465                 470                 475                 480 


Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys Lys Ile Glu Thr 
                485                 490                 495     


Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val Leu Pro Lys 
            500                 505                 510     


<210>  6050
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRT9__Homo_sapiens__NP_000217

<400>  6050

Met Ser Cys Arg Gln Phe Ser Ser Ser Tyr Leu Ser Arg Ser Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Leu Gly Ser Gly Gly Ser Ile Arg Ser Ser Tyr 
            20                  25                  30          


Ser Arg Phe Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Arg Phe Ser 
        35                  40                  45              


Ser Ser Ser Gly Tyr Gly Gly Gly Ser Ser Arg Val Cys Gly Arg Gly 
    50                  55                  60                  


Gly Gly Gly Ser Phe Gly Tyr Ser Tyr Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Phe Ser Ala Ser Ser Leu Gly Gly Gly Phe Gly Gly Gly Ser Arg Gly 
                85                  90                  95      


Phe Gly Gly Ala Ser Gly Gly Gly Tyr Ser Ser Ser Gly Gly Phe Gly 
            100                 105                 110         


Gly Gly Phe Gly Gly Gly Ser Gly Gly Gly Phe Gly Gly Gly Tyr Gly 
        115                 120                 125             


Ser Gly Phe Gly Gly Phe Gly Gly Phe Gly Gly Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asp Gly Gly Ile Leu Thr Ala Asn Glu Lys Ser Thr Met Gln Glu Leu 
145                 150                 155                 160 


Asn Ser Arg Leu Ala Ser Tyr Leu Asp Lys Val Gln Ala Leu Glu Glu 
                165                 170                 175     


Ala Asn Asn Asp Leu Glu Asn Lys Ile Gln Asp Trp Tyr Asp Lys Lys 
            180                 185                 190         


Gly Pro Ala Ala Ile Gln Lys Asn Tyr Ser Pro Tyr Tyr Asn Thr Ile 
        195                 200                 205             


Asp Asp Leu Lys Asp Gln Ile Val Asp Leu Thr Val Gly Asn Asn Lys 
    210                 215                 220                 


Thr Leu Leu Asp Ile Asp Asn Thr Arg Met Thr Leu Asp Asp Phe Arg 
225                 230                 235                 240 


Ile Lys Phe Glu Met Glu Gln Asn Leu Arg Gln Gly Val Asp Ala Asp 
                245                 250                 255     


Ile Asn Gly Leu Arg Gln Val Leu Asp Asn Leu Thr Met Glu Lys Ser 
            260                 265                 270         


Asp Leu Glu Met Gln Tyr Glu Thr Leu Gln Glu Glu Leu Met Ala Leu 
        275                 280                 285             


Lys Lys Asn His Lys Glu Glu Met Ser Gln Leu Thr Gly Gln Asn Ser 
    290                 295                 300                 


Gly Asp Val Asn Val Glu Ile Asn Val Ala Pro Gly Lys Asp Leu Thr 
305                 310                 315                 320 


Lys Thr Leu Asn Asp Met Arg Gln Glu Tyr Glu Gln Leu Ile Ala Lys 
                325                 330                 335     


Asn Arg Lys Asp Ile Glu Asn Gln Tyr Glu Thr Gln Ile Thr Gln Ile 
            340                 345                 350         


Glu His Glu Val Ser Ser Ser Gly Gln Glu Val Gln Ser Ser Ala Lys 
        355                 360                 365             


Glu Val Thr Gln Leu Arg His Gly Val Gln Glu Leu Glu Ile Glu Leu 
    370                 375                 380                 


Gln Ser Gln Leu Ser Lys Lys Ala Ala Leu Glu Lys Ser Leu Glu Asp 
385                 390                 395                 400 


Thr Lys Asn Arg Tyr Cys Gly Gln Leu Gln Met Ile Gln Glu Gln Ile 
                405                 410                 415     


Ser Asn Leu Glu Ala Gln Ile Thr Asp Val Arg Gln Glu Ile Glu Cys 
            420                 425                 430         


Gln Asn Gln Glu Tyr Ser Leu Leu Leu Ser Ile Lys Met Arg Leu Glu 
        435                 440                 445             


Lys Glu Ile Glu Thr Tyr His Asn Leu Leu Glu Gly Gly Gln Glu Asp 
    450                 455                 460                 


Phe Glu Ser Ser Gly Ala Gly Lys Ile Gly Leu Gly Gly Arg Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Ser Tyr Gly Arg Gly Ser Arg Gly Gly Ser Gly Gly Ser 
                485                 490                 495     


Tyr Gly Gly Gly Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Ser 
            500                 505                 510         


Arg Gly Gly Ser Gly Gly Ser Tyr Gly Gly Gly Ser Gly Ser Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Gly Gly His Ser Gly 
    530                 535                 540                 


Gly Ser Gly Gly Gly His Ser Gly Gly Ser Gly Gly Asn Tyr Gly Gly 
545                 550                 555                 560 


Gly Ser Gly Ser Gly Gly Gly Ser Gly Gly Gly Tyr Gly Gly Gly Ser 
                565                 570                 575     


Gly Ser Arg Gly Gly Ser Gly Gly Ser His Gly Gly Gly Ser Gly Phe 
            580                 585                 590         


Gly Gly Glu Ser Gly Gly Ser Tyr Gly Gly Gly Glu Glu Ala Ser Gly 
        595                 600                 605             


Ser Gly Gly Gly Tyr Gly Gly Gly Ser Gly Lys Ser Ser His Ser 
    610                 615                 620             


<210>  6051
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRTAP11-1__Homo_sapiens__NP_787054

<400>  6051

Met Ser Phe Asn Cys Ser Thr Arg Asn Cys Ser Ser Arg Pro Ile Gly 
1               5                   10                  15      


Gly Arg Cys Ile Val Pro Val Ala Gln Val Thr Thr Thr Ser Thr Thr 
            20                  25                  30          


Asp Ala Asp Cys Leu Gly Gly Ile Cys Leu Pro Ser Ser Phe Gln Thr 
        35                  40                  45              


Gly Ser Trp Leu Leu Asp His Cys Gln Glu Thr Cys Cys Glu Pro Thr 
    50                  55                  60                  


Ala Cys Gln Pro Thr Cys Tyr Arg Arg Thr Ser Cys Val Ser Asn Pro 
65                  70                  75                  80  


Cys Gln Val Thr Cys Ser Arg Gln Thr Thr Cys Ile Ser Asn Pro Cys 
                85                  90                  95      


Ser Thr Thr Tyr Ser Arg Pro Leu Thr Phe Val Ser Ser Gly Cys Gln 
            100                 105                 110         


Pro Leu Gly Gly Ile Ser Ser Val Cys Gln Pro Val Gly Gly Ile Ser 
        115                 120                 125             


Thr Val Cys Gln Pro Val Gly Gly Val Ser Thr Val Cys Gln Pro Ala 
    130                 135                 140                 


Cys Gly Val Ser Arg Thr Tyr Gln Gln Ser Cys Val Ser Ser Cys Arg 
145                 150                 155                 160 


Arg Thr Cys 
            


<210>  6052
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRTAP5-1__Homo_sapiens__NP_001005922

<400>  6052

Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Ser Cys Gly Gly 
1               5                   10                  15      


Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly 
            20                  25                  30          


Ser Gly Cys Gly Gly Ser Gly Ser Ser Cys Cys Val Pro Val Cys Cys 
        35                  40                  45              


Cys Lys Pro Val Cys Cys Arg Val Pro Thr Cys Ser Cys Ser Ser Cys 
    50                  55                  60                  


Gly Lys Gly Gly Cys Gly Ser Ser Gly Gly Ser Lys Gly Gly Cys Gly 
65                  70                  75                  80  


Ser Cys Gly Gly Cys Lys Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys 
                85                  90                  95      


Gly Gly Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys 
            100                 105                 110         


Gly Gly Ser Lys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser 
        115                 120                 125             


Ser Cys Cys Val Pro Val Cys Cys Cys Lys Pro Met Cys Cys Cys Val 
    130                 135                 140                 


Pro Ala Cys Ser Cys Ser Ser Cys Gly Lys Gly Gly Cys Gly Ser Cys 
145                 150                 155                 160 


Gly Cys Ser Lys Gly Ala Cys Gly Ser Cys Gly Gly Ser Lys Gly Gly 
                165                 170                 175     


Cys Gly Ser Cys Gly Gly Cys Lys Gly Gly Cys Gly Ser Cys Gly Gly 
            180                 185                 190         


Ser Lys Gly Gly Cys Gly Ser Gly Cys Gly Gly Cys Gly Ser Gly Cys 
        195                 200                 205             


Gly Val Pro Val Cys Cys Cys Ser Cys Ser Ser Cys Gly Ser Cys Ala 
    210                 215                 220                 


Gly Ser Lys Gly Gly Cys Gly Ser Ser Cys Ser Gln Cys Ser Cys Cys 
225                 230                 235                 240 


Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys Cys Gln Ser 
                245                 250                 255     


Ser Cys Cys Lys Pro Cys Cys Ser Gln Ser Ser Cys Cys Val Pro Val 
            260                 265                 270         


Cys Cys Gln Cys Lys Ile 
        275             


<210>  6053
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRTAP5-9__Homo_sapiens__NP_005544

<400>  6053

Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly Ser Ser Cys Gly Gly 
1               5                   10                  15      


Cys Asp Ser Ser Cys Gly Ser Cys Gly Ser Gly Cys Arg Gly Cys Gly 
            20                  25                  30          


Pro Ser Cys Cys Ala Pro Val Tyr Cys Cys Lys Pro Val Cys Cys Cys 
        35                  40                  45              


Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Lys Arg Gly Cys Gly Ser 
    50                  55                  60                  


Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Cys Ser Gln Cys 
65                  70                  75                  80  


Ser Cys Cys Lys Pro Cys Cys Cys Ser Ser Gly Cys Gly Ser Ser Cys 
                85                  90                  95      


Cys Gln Cys Ser Cys Cys Lys Pro Tyr Cys Ser Gln Cys Ser Cys Cys 
            100                 105                 110         


Lys Pro Cys Cys Ser Ser Ser Gly Arg Gly Ser Ser Cys Cys Gln Ser 
        115                 120                 125             


Ser Cys Cys Lys Pro Cys Cys Ser Ser Ser Gly Cys Gly Ser Ser Cys 
    130                 135                 140                 


Cys Gln Ser Ser Cys Cys Lys Pro Cys Cys Ser Gln Ser Arg Cys Cys 
145                 150                 155                 160 


Val Pro Val Cys Tyr Gln Cys Lys Ile 
                165                 


<210>  6054
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KSR1__Homo_sapiens__XP_006722214

<400>  6054

Met Asp Arg Ala Ala Leu Arg Ala Ala Ala Met Gly Glu Lys Lys Glu 
1               5                   10                  15      


Gly Gly Gly Gly Gly Asp Ala Ala Ala Ala Glu Gly Gly Ala Gly Ala 
            20                  25                  30          


Ala Ala Ser Arg Ala Leu Gln Gln Cys Gly Gln Leu Gln Lys Leu Ile 
        35                  40                  45              


Asp Ile Ser Ile Gly Ser Leu Arg Gly Leu Arg Thr Lys Cys Ala Val 
    50                  55                  60                  


Ser Asn Asp Leu Thr Gln Gln Glu Ile Arg Thr Leu Glu Ala Lys Leu 
65                  70                  75                  80  


Val Arg Tyr Ile Cys Lys Gln Arg Gln Cys Lys Leu Ser Val Ala Pro 
                85                  90                  95      


Gly Glu Arg Thr Pro Glu Leu Asn Ser Tyr Pro Arg Phe Ser Asp Trp 
            100                 105                 110         


Leu Tyr Thr Phe Asn Val Arg Pro Glu Val Val Gln Glu Ile Pro Arg 
        115                 120                 125             


Asp Leu Thr Leu Asp Ala Leu Leu Glu Met Asn Glu Ala Lys Val Lys 
    130                 135                 140                 


Glu Thr Leu Arg Arg Cys Gly Ala Ser Gly Asp Glu Cys Gly Arg Leu 
145                 150                 155                 160 


Gln Tyr Ala Leu Thr Cys Leu Arg Lys Val Thr Gly Leu Gly Gly Glu 
                165                 170                 175     


His Lys Glu Asp Ser Ser Trp Ser Ser Leu Asp Ala Arg Arg Glu Ser 
            180                 185                 190         


Gly Ser Gly Pro Ser Thr Asp Thr Leu Ser Ala Ala Ser Leu Pro Trp 
        195                 200                 205             


Pro Pro Gly Ser Ser Gln Leu Gly Arg Ala Gly Asn Ser Ala Gln Gly 
    210                 215                 220                 


Pro Arg Ser Ile Ser Val Ser Ala Leu Pro Ala Ser Asp Ser Pro Thr 
225                 230                 235                 240 


Pro Ser Phe Ser Glu Gly Leu Ser Asp Thr Cys Ile Pro Leu His Ala 
                245                 250                 255     


Ser Gly Arg Leu Thr Pro Arg Ala Leu His Ser Phe Ile Thr Pro Pro 
            260                 265                 270         


Thr Thr Pro Gln Leu Arg Arg His Thr Lys Leu Lys Pro Pro Arg Thr 
        275                 280                 285             


Pro Pro Pro Pro Ser Arg Lys Val Phe Gln Leu Leu Pro Ser Phe Pro 
    290                 295                 300                 


Thr Leu Thr Arg Ser Lys Ser His Glu Ser Gln Leu Gly Asn Arg Ile 
305                 310                 315                 320 


Asp Asp Val Ser Ser Met Arg Phe Asp Leu Ser His Gly Ser Pro Gln 
                325                 330                 335     


Met Val Arg Arg Asp Ile Gly Leu Ser Val Thr His Arg Phe Ser Thr 
            340                 345                 350         


Lys Ser Trp Leu Ser Gln Val Cys His Val Cys Gln Lys Ser Met Ile 
        355                 360                 365             


Phe Gly Val Lys Cys Lys His Cys Arg Leu Lys Cys His Asn Lys Cys 
    370                 375                 380                 


Thr Lys Glu Ala Pro Ala Cys Arg Ile Ser Phe Leu Pro Leu Thr Arg 
385                 390                 395                 400 


Leu Arg Arg Thr Glu Ser Val Pro Ser Asp Ile Asn Asn Pro Val Asp 
                405                 410                 415     


Arg Ala Ala Glu Pro His Phe Gly Thr Leu Pro Lys Ala Leu Thr Lys 
            420                 425                 430         


Lys Glu His Pro Pro Ala Met Asn His Leu Asp Ser Ser Ser Asn Pro 
        435                 440                 445             


Ser Ser Thr Thr Ser Ser Thr Pro Ser Ser Pro Ala Pro Phe Pro Thr 
    450                 455                 460                 


Ser Ser Asn Pro Ser Ser Ala Thr Thr Pro Pro Asn Pro Ser Pro Gly 
465                 470                 475                 480 


Gln Arg Asp Ser Arg Phe Asn Phe Pro Ala Ala Tyr Phe Ile His His 
                485                 490                 495     


Arg Gln Gln Phe Ile Phe Pro Asp Ile Ser Ala Phe Ala His Ala Ala 
            500                 505                 510         


Pro Leu Pro Glu Ala Ala Asp Gly Thr Arg Leu Asp Asp Gln Pro Lys 
        515                 520                 525             


Ala Asp Val Leu Glu Ala His Glu Ala Glu Ala Glu Glu Pro Glu Ala 
    530                 535                 540                 


Gly Lys Ser Glu Ala Glu Asp Asp Glu Asp Glu Val Asp Asp Leu Pro 
545                 550                 555                 560 


Ser Ser Arg Arg Pro Trp Arg Gly Pro Ile Ser Arg Lys Ala Ser Gln 
                565                 570                 575     


Thr Ser Val Tyr Leu Gln Glu Trp Asp Ile Pro Phe Glu Gln Val Glu 
            580                 585                 590         


Leu Gly Glu Pro Ile Gly Gln Gly Arg Trp Gly Arg Val His Arg Gly 
        595                 600                 605             


Arg Trp His Gly Glu Val Ala Ile Arg Leu Leu Glu Met Asp Gly His 
    610                 615                 620                 


Asn Gln Asp His Leu Lys Leu Phe Lys Lys Glu Val Met Asn Tyr Arg 
625                 630                 635                 640 


Gln Thr Arg His Glu Asn Val Val Leu Phe Met Gly Ala Cys Met Asn 
                645                 650                 655     


Pro Pro His Leu Ala Ile Ile Thr Ser Phe Cys Lys Gly Arg Thr Leu 
            660                 665                 670         


His Ser Phe Val Arg Asp Pro Lys Thr Ser Leu Asp Ile Asn Lys Thr 
        675                 680                 685             


Arg Gln Ile Ala Gln Glu Ile Ile Lys Gly Met Gly Tyr Leu His Ala 
    690                 695                 700                 


Lys Gly Ile Val His Lys Asp Leu Lys Ser Lys Asn Val Phe Tyr Asp 
705                 710                 715                 720 


Asn Gly Lys Val Val Ile Thr Asp Phe Gly Leu Phe Gly Ile Ser Gly 
                725                 730                 735     


Val Val Arg Glu Gly Arg Arg Glu Asn Gln Leu Lys Leu Ser His Asp 
            740                 745                 750         


Trp Leu Cys Tyr Leu Ala Pro Glu Ile Val Arg Glu Met Thr Pro Gly 
        755                 760                 765             


Lys Asp Glu Asp Gln Leu Pro Phe Ser Lys Ala Ala Asp Val Tyr Ala 
    770                 775                 780                 


Phe Gly Thr Val Trp Tyr Glu Leu Gln Ala Arg Asp Trp Pro Leu Lys 
785                 790                 795                 800 


Asn Gln Ala Ala Glu Ala Ser Ile Trp Gln Ile Gly Ser Gly Glu Gly 
                805                 810                 815     


Met Lys Arg Val Leu Thr Ser Val Ser Leu Gly Lys Glu Val Ser Glu 
            820                 825                 830         


Ile Leu Ser Ala Cys Trp Ala Phe Asp Leu Gln Glu Arg Pro Ser Phe 
        835                 840                 845             


Ser Leu Leu Met Asp Met Leu Glu Lys Leu Pro Lys Leu Asn Arg Arg 
    850                 855                 860                 


Leu Ser His Pro Gly His Phe Trp Lys Ser Ala Asp Arg Trp Arg Ser 
865                 870                 875                 880 


Arg Tyr Tyr Gly Lys Gly Arg Tyr Gly His Pro Asp Phe Lys Ser Ser 
                885                 890                 895     


Cys Pro Ile Leu Glu Glu Tyr Ile Asn Ser Ser Lys Val Val Pro Arg 
            900                 905                 910         


Phe Glu Arg Phe Gly Leu Gly Val Leu Glu Ser Ser Asn Pro Lys Met 
        915                 920                 925             


<210>  6055
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KSR2__Homo_sapiens__NP_775869

<400>  6055

Met Ile Asp Leu Ser Ile Ser Asn Leu Glu Gly Leu Arg Thr Lys Cys 
1               5                   10                  15      


Ala Thr Ser Asn Asp Leu Thr Gln Lys Glu Ile Arg Thr Leu Glu Ser 
            20                  25                  30          


Lys Leu Val Lys Tyr Phe Ser Arg Gln Leu Ser Cys Lys Lys Lys Val 
        35                  40                  45              


Ala Leu Gln Glu Arg Asn Ala Glu Leu Asp Gly Phe Pro Gln Leu Arg 
    50                  55                  60                  


His Trp Phe Arg Ile Val Asp Val Arg Lys Glu Val Leu Glu Glu Ile 
65                  70                  75                  80  


Ser Pro Gly Gln Leu Ser Leu Glu Asp Leu Leu Glu Met Thr Asp Glu 
                85                  90                  95      


Gln Val Cys Glu Thr Val Glu Lys Tyr Gly Ala Asn Arg Glu Glu Cys 
            100                 105                 110         


Ala Arg Leu Asn Ala Ser Leu Ser Cys Leu Arg Asn Val His Met Ser 
        115                 120                 125             


Gly Gly Asn Leu Ser Lys Gln Asp Trp Thr Ile Gln Trp Pro Thr Thr 
    130                 135                 140                 


Glu Thr Gly Lys Glu Asn Asn Pro Val Cys Pro Pro Glu Pro Thr Pro 
145                 150                 155                 160 


Trp Ile Arg Thr His Leu Ser Gln Ser Pro Arg Val Pro Ser Lys Cys 
                165                 170                 175     


Val Gln His Tyr Cys His Thr Ser Pro Thr Pro Gly Ala Pro Val Tyr 
            180                 185                 190         


Thr His Val Asp Arg Leu Thr Val Asp Ala Tyr Pro Gly Leu Cys Pro 
        195                 200                 205             


Pro Pro Pro Leu Glu Ser Gly His Arg Ser Leu Pro Pro Ser Pro Arg 
    210                 215                 220                 


Gln Arg His Ala Val Arg Thr Pro Pro Arg Thr Pro Asn Ile Val Thr 
225                 230                 235                 240 


Thr Val Thr Pro Pro Gly Thr Pro Pro Met Arg Lys Lys Asn Lys Leu 
                245                 250                 255     


Lys Pro Pro Gly Thr Pro Pro Pro Ser Ser Arg Lys Leu Ile His Leu 
            260                 265                 270         


Ile Pro Gly Phe Thr Ala Leu His Arg Ser Lys Ser His Glu Phe Gln 
        275                 280                 285             


Leu Gly His Arg Val Asp Glu Ala His Thr Pro Lys Ala Lys Lys Lys 
    290                 295                 300                 


Ser Lys Pro Leu Asn Leu Lys Ile His Ser Ser Val Gly Ser Cys Glu 
305                 310                 315                 320 


Asn Ile Pro Ser Gln Gln Arg Ser Pro Leu Leu Ser Glu Arg Ser Leu 
                325                 330                 335     


Arg Ser Phe Phe Val Gly His Ala Pro Phe Leu Pro Ser Thr Pro Pro 
            340                 345                 350         


Val His Thr Glu Ala Asn Phe Ser Ala Asn Thr Leu Ser Val Pro Arg 
        355                 360                 365             


Trp Ser Pro Gln Ile Pro Arg Arg Asp Leu Gly Asn Ser Ile Lys His 
    370                 375                 380                 


Arg Phe Ser Thr Lys Tyr Trp Met Ser Gln Thr Cys Thr Val Cys Gly 
385                 390                 395                 400 


Lys Gly Met Leu Phe Gly Leu Lys Cys Lys Asn Cys Lys Leu Lys Cys 
                405                 410                 415     


His Asn Lys Cys Thr Lys Glu Ala Pro Pro Cys His Leu Leu Ile Ile 
            420                 425                 430         


His Arg Gly Asp Pro Ala Arg Leu Val Arg Thr Glu Ser Val Pro Cys 
        435                 440                 445             


Asp Ile Asn Asn Pro Leu Arg Lys Pro Pro Arg Tyr Ser Asp Leu His 
    450                 455                 460                 


Ile Ser Gln Thr Leu Pro Lys Thr Asn Lys Ile Asn Lys Asp His Ile 
465                 470                 475                 480 


Pro Val Pro Tyr Gln Pro Asp Ser Ser Ser Asn Pro Ser Ser Thr Thr 
                485                 490                 495     


Ser Ser Thr Pro Ser Ser Pro Ala Pro Pro Leu Pro Pro Ser Ala Thr 
            500                 505                 510         


Pro Pro Ser Pro Leu His Pro Ser Pro Gln Cys Thr Arg Gln Gln Lys 
        515                 520                 525             


Asn Phe Asn Leu Pro Ala Ser His Tyr Tyr Lys Tyr Lys Gln Gln Phe 
    530                 535                 540                 


Ile Phe Pro Asp Val Val Pro Val Pro Glu Thr Pro Thr Arg Ala Pro 
545                 550                 555                 560 


Gln Val Ile Leu His Pro Val Thr Ser Asn Pro Ile Leu Glu Gly Asn 
                565                 570                 575     


Pro Leu Leu Gln Ile Glu Val Glu Pro Thr Ser Glu Asn Glu Glu Val 
            580                 585                 590         


His Asp Glu Ala Glu Glu Ser Glu Asp Asp Phe Glu Glu Met Asn Leu 
        595                 600                 605             


Ser Leu Leu Ser Ala Arg Ser Phe Pro Arg Lys Ala Ser Gln Thr Ser 
    610                 615                 620                 


Ile Phe Leu Gln Glu Trp Asp Ile Pro Phe Glu Gln Leu Glu Ile Gly 
625                 630                 635                 640 


Glu Leu Ile Gly Lys Gly Arg Phe Gly Gln Val Tyr His Gly Arg Trp 
                645                 650                 655     


His Gly Glu Val Ala Ile Arg Leu Ile Asp Ile Glu Arg Asp Asn Glu 
            660                 665                 670         


Asp Gln Leu Lys Ala Phe Lys Arg Glu Val Met Ala Tyr Arg Gln Thr 
        675                 680                 685             


Arg His Glu Asn Val Val Leu Phe Met Gly Ala Cys Met Ser Pro Pro 
    690                 695                 700                 


His Leu Ala Ile Ile Thr Ser Leu Cys Lys Gly Arg Thr Leu Tyr Ser 
705                 710                 715                 720 


Val Val Arg Asp Ala Lys Ile Val Leu Asp Val Asn Lys Thr Arg Gln 
                725                 730                 735     


Ile Ala Gln Glu Ile Val Lys Gly Met Gly Tyr Leu His Ala Lys Gly 
            740                 745                 750         


Ile Leu His Lys Asp Leu Lys Ser Lys Asn Val Phe Tyr Asp Asn Gly 
        755                 760                 765             


Lys Val Val Ile Thr Asp Phe Gly Leu Phe Ser Ile Ser Gly Val Leu 
    770                 775                 780                 


Gln Ala Gly Arg Arg Glu Asp Lys Leu Arg Ile Gln Asn Gly Trp Leu 
785                 790                 795                 800 


Cys His Leu Ala Pro Glu Ile Ile Arg Gln Leu Ser Pro Asp Thr Glu 
                805                 810                 815     


Glu Asp Lys Leu Pro Phe Ser Lys His Ser Asp Val Phe Ala Leu Gly 
            820                 825                 830         


Thr Ile Trp Tyr Glu Leu His Ala Arg Glu Trp Pro Phe Lys Thr Gln 
        835                 840                 845             


Pro Ala Glu Ala Ile Ile Trp Gln Met Gly Thr Gly Met Lys Pro Asn 
    850                 855                 860                 


Leu Ser Gln Ile Gly Met Gly Lys Glu Ile Ser Asp Ile Leu Leu Phe 
865                 870                 875                 880 


Cys Trp Ala Phe Glu Gln Glu Glu Arg Pro Thr Phe Thr Lys Leu Met 
                885                 890                 895     


Asp Met Leu Glu Lys Leu Pro Lys Arg Asn Arg Arg Leu Ser His Pro 
            900                 905                 910         


Gly His Phe Trp Lys Ser Ala Glu Leu 
        915                 920     


<210>  6056
<211>  1357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KTN1__Homo_sapiens__NP_001072989

<400>  6056

Met Glu Phe Tyr Glu Ser Ala Tyr Phe Ile Val Leu Ile Pro Ser Ile 
1               5                   10                  15      


Val Ile Thr Val Ile Phe Leu Phe Phe Trp Leu Phe Met Lys Glu Thr 
            20                  25                  30          


Leu Tyr Asp Glu Val Leu Ala Lys Gln Lys Arg Glu Gln Lys Leu Ile 
        35                  40                  45              


Pro Thr Lys Thr Asp Lys Lys Lys Ala Glu Lys Lys Lys Asn Lys Lys 
    50                  55                  60                  


Lys Glu Ile Gln Asn Gly Asn Leu His Glu Ser Asp Ser Glu Ser Val 
65                  70                  75                  80  


Pro Arg Asp Phe Lys Leu Ser Asp Ala Leu Ala Val Glu Asp Asp Gln 
                85                  90                  95      


Val Ala Pro Val Pro Leu Asn Val Val Glu Thr Ser Ser Ser Val Arg 
            100                 105                 110         


Glu Arg Lys Lys Lys Glu Lys Lys Gln Lys Pro Val Leu Glu Glu Gln 
        115                 120                 125             


Val Ile Lys Glu Ser Asp Ala Ser Lys Ile Pro Gly Lys Lys Val Glu 
    130                 135                 140                 


Pro Val Pro Val Thr Lys Gln Pro Thr Pro Pro Ser Glu Ala Ala Ala 
145                 150                 155                 160 


Ser Lys Lys Lys Pro Gly Gln Lys Lys Ser Lys Asn Gly Ser Asp Asp 
                165                 170                 175     


Gln Asp Lys Lys Val Glu Thr Leu Met Val Pro Ser Lys Arg Gln Glu 
            180                 185                 190         


Ala Leu Pro Leu His Gln Glu Thr Lys Gln Glu Ser Gly Ser Gly Lys 
        195                 200                 205             


Lys Lys Ala Ser Ser Lys Lys Gln Lys Thr Glu Asn Val Phe Val Asp 
    210                 215                 220                 


Glu Pro Leu Ile His Ala Thr Thr Tyr Ile Pro Leu Met Asp Asn Ala 
225                 230                 235                 240 


Asp Ser Ser Pro Val Val Asp Lys Arg Glu Val Ile Asp Leu Leu Lys 
                245                 250                 255     


Pro Asp Gln Val Glu Gly Ile Gln Lys Ser Gly Thr Lys Lys Leu Lys 
            260                 265                 270         


Thr Glu Thr Asp Lys Glu Asn Ala Glu Val Lys Phe Lys Asp Phe Leu 
        275                 280                 285             


Leu Ser Leu Lys Thr Met Met Phe Ser Glu Asp Glu Ala Leu Cys Val 
    290                 295                 300                 


Val Asp Leu Leu Lys Glu Lys Ser Gly Val Ile Gln Asp Ala Leu Lys 
305                 310                 315                 320 


Lys Ser Ser Lys Gly Glu Leu Thr Thr Leu Ile His Gln Leu Gln Glu 
                325                 330                 335     


Lys Asp Lys Leu Leu Ala Ala Val Lys Glu Asp Ala Ala Ala Thr Lys 
            340                 345                 350         


Asp Arg Cys Lys Gln Leu Thr Gln Glu Met Met Thr Glu Lys Glu Arg 
        355                 360                 365             


Ser Asn Val Val Ile Thr Arg Met Lys Asp Arg Ile Gly Thr Leu Glu 
    370                 375                 380                 


Lys Glu His Asn Val Phe Gln Asn Lys Ile His Val Ser Tyr Gln Glu 
385                 390                 395                 400 


Thr Gln Gln Met Gln Met Lys Phe Gln Gln Val Arg Glu Gln Met Glu 
                405                 410                 415     


Ala Glu Ile Ala His Leu Lys Gln Glu Asn Gly Ile Leu Arg Asp Ala 
            420                 425                 430         


Val Ser Asn Thr Thr Asn Gln Leu Glu Ser Lys Gln Ser Ala Glu Leu 
        435                 440                 445             


Asn Lys Leu Arg Gln Asp Tyr Ala Arg Leu Val Asn Glu Leu Thr Glu 
    450                 455                 460                 


Lys Thr Gly Lys Leu Gln Gln Glu Glu Val Gln Lys Lys Asn Ala Glu 
465                 470                 475                 480 


Gln Ala Ala Thr Gln Leu Lys Val Gln Leu Gln Glu Ala Glu Arg Arg 
                485                 490                 495     


Trp Glu Glu Val Gln Ser Tyr Ile Arg Lys Arg Thr Ala Glu His Glu 
            500                 505                 510         


Ala Ala Gln Gln Asp Leu Gln Ser Lys Phe Val Ala Lys Glu Asn Glu 
        515                 520                 525             


Val Gln Ser Leu His Ser Lys Leu Thr Asp Thr Leu Val Ser Lys Gln 
    530                 535                 540                 


Gln Leu Glu Gln Arg Leu Met Gln Leu Met Glu Ser Glu Gln Lys Arg 
545                 550                 555                 560 


Val Asn Lys Glu Glu Ser Leu Gln Met Gln Val Gln Asp Ile Leu Glu 
                565                 570                 575     


Gln Asn Glu Ala Leu Lys Ala Gln Ile Gln Gln Phe His Ser Gln Ile 
            580                 585                 590         


Ala Ala Gln Thr Ser Ala Ser Val Leu Ala Glu Glu Leu His Lys Val 
        595                 600                 605             


Ile Ala Glu Lys Asp Lys Gln Ile Lys Gln Thr Glu Asp Ser Leu Ala 
    610                 615                 620                 


Ser Glu Arg Asp Arg Leu Thr Ser Lys Glu Glu Glu Leu Lys Asp Ile 
625                 630                 635                 640 


Gln Asn Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala 
                645                 650                 655     


Leu Ala Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln 
            660                 665                 670         


Gln Ser Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln 
        675                 680                 685             


Leu Gln His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn 
    690                 695                 700                 


Asp Gln Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu 
705                 710                 715                 720 


Val Ser Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys 
                725                 730                 735     


Ile Gln Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu 
            740                 745                 750         


Thr Gly Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile 
        755                 760                 765             


Arg Thr Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala 
    770                 775                 780                 


Lys Gln Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys 
785                 790                 795                 800 


Lys Val Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu 
                805                 810                 815     


Leu Glu Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln 
            820                 825                 830         


Asp Leu Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val 
        835                 840                 845             


Gln Leu Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu 
    850                 855                 860                 


Leu Gln Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys 
865                 870                 875                 880 


Ala Val Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp 
                885                 890                 895     


Leu Gln Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln 
            900                 905                 910         


Glu Val Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe 
        915                 920                 925             


Glu Glu Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg 
    930                 935                 940                 


Leu Glu Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr 
945                 950                 955                 960 


Gln Leu Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln 
                965                 970                 975     


Ile Glu Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro 
            980                 985                 990         


Pro His Glu Glu Leu Leu Lys Val  Ile Ser Glu Arg Glu  Lys Glu Ile 
        995                 1000                 1005             


Ser Gly  Leu Trp Asn Glu Leu  Asp Ser Leu Lys Asp  Ala Val Glu 
    1010                 1015                 1020             


His Gln  Arg Lys Lys Asn Asn  Asp Leu Arg Glu Lys  Asn Trp Glu 
    1025                 1030                 1035             


Ala Met  Glu Ala Leu Ala Ser  Thr Glu Lys Met Leu  Gln Asp Lys 
    1040                 1045                 1050             


Val Asn  Lys Thr Ser Lys Glu  Arg Gln Gln Gln Val  Glu Ala Val 
    1055                 1060                 1065             


Glu Leu  Glu Ala Lys Glu Val  Leu Lys Lys Leu Phe  Pro Lys Val 
    1070                 1075                 1080             


Ser Val  Pro Ser Asn Leu Ser  Tyr Gly Glu Trp Leu  His Gly Phe 
    1085                 1090                 1095             


Glu Lys  Lys Ala Lys Glu Cys  Met Ala Gly Thr Ser  Gly Ser Glu 
    1100                 1105                 1110             


Glu Val  Lys Val Leu Glu His  Lys Leu Lys Glu Ala  Asp Glu Met 
    1115                 1120                 1125             


His Thr  Leu Leu Gln Leu Glu  Cys Glu Lys Tyr Lys  Ser Val Leu 
    1130                 1135                 1140             


Ala Glu  Thr Glu Gly Ile Leu  Gln Lys Leu Gln Arg  Ser Val Glu 
    1145                 1150                 1155             


Gln Glu  Glu Asn Lys Trp Lys  Val Lys Val Asp Glu  Ser His Lys 
    1160                 1165                 1170             


Thr Ile  Lys Gln Met Gln Ser  Ser Phe Thr Ser Ser  Glu Gln Glu 
    1175                 1180                 1185             


Leu Glu  Arg Leu Arg Ser Glu  Asn Lys Asp Ile Glu  Asn Leu Arg 
    1190                 1195                 1200             


Arg Glu  Arg Glu His Leu Glu  Met Glu Leu Glu Lys  Ala Glu Met 
    1205                 1210                 1215             


Glu Arg  Ser Thr Tyr Val Thr  Glu Val Arg Glu Leu  Lys Asp Leu 
    1220                 1225                 1230             


Leu Thr  Glu Leu Gln Lys Lys  Leu Asp Asp Ser Tyr  Ser Glu Ala 
    1235                 1240                 1245             


Val Arg  Gln Asn Glu Glu Leu  Asn Leu Leu Lys Ala  Gln Leu Asn 
    1250                 1255                 1260             


Glu Thr  Leu Thr Lys Leu Arg  Thr Glu Gln Asn Glu  Arg Gln Lys 
    1265                 1270                 1275             


Val Ala  Gly Asp Leu His Lys  Ala Gln Gln Ser Leu  Glu Leu Ile 
    1280                 1285                 1290             


Gln Ser  Lys Ile Val Lys Ala  Ala Gly Asp Thr Thr  Val Ile Glu 
    1295                 1300                 1305             


Asn Ser  Asp Val Ser Pro Glu  Thr Glu Ser Ser Glu  Lys Glu Thr 
    1310                 1315                 1320             


Met Ser  Val Ser Leu Asn Gln  Thr Val Thr Gln Leu  Gln Gln Leu 
    1325                 1330                 1335             


Leu Gln  Ala Val Asn Gln Gln  Leu Thr Lys Glu Lys  Glu His Tyr 
    1340                 1345                 1350             


Gln Val  Leu Glu 
    1355         


<210>  6057
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KYNU__Homo_sapiens__NP_001028170

<400>  6057

Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Arg Ser Glu 
    290                 295                 300                 


Phe Phe Asn 
305         


<210>  6058
<211>  1257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1CAM__Homo_sapiens__NP_000416

<400>  6058

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 
    1175                 1180                 1185             


Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 
    1190                 1195                 1200             


Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 
    1205                 1210                 1215             


Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 
    1220                 1225                 1230             


Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 
    1235                 1240                 1245             


Pro Ile  Asn Pro Ala Val Ala  Leu Glu 
    1250                 1255         


<210>  6059
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2HGDH__Homo_sapiens__XP_005268132

<400>  6059

Met Val Pro Ala Leu Arg Tyr Leu Val Gly Ala Cys Gly Arg Ala Arg 
1               5                   10                  15      


Gly Leu Phe Ala Gly Gly Ser Pro Gly Ala Cys Gly Phe Ala Ser Gly 
            20                  25                  30          


Arg Pro Arg Pro Leu Cys Gly Gly Ser Arg Ser Ala Ser Thr Ser Ser 
        35                  40                  45              


Phe Asp Ile Val Ile Val Gly Gly Gly Ile Val Gly Leu Ala Ser Ala 
    50                  55                  60                  


Arg Ala Leu Ile Leu Arg His Pro Ser Leu Ser Ile Gly Val Leu Glu 
65                  70                  75                  80  


Lys Glu Lys Asp Leu Ala Val His Gln Thr Gly His Asn Ser Gly Val 
                85                  90                  95      


Ile His Ser Gly Ile Tyr Tyr Lys Pro Glu Ser Leu Lys Ala Lys Leu 
            100                 105                 110         


Cys Val Gln Gly Ala Ala Leu Leu Tyr Glu Tyr Cys Gln Gln Lys Gly 
        115                 120                 125             


Ile Ser Tyr Lys Gln Cys Gly Lys Leu Ile Val Ala Val Glu Gln Glu 
    130                 135                 140                 


Glu Ile Pro Arg Leu Gln Ala Leu Tyr Glu Lys Gly Leu Gln Asn Gly 
145                 150                 155                 160 


Val Pro Gly Leu Arg Leu Ile Gln Gln Glu Asp Ile Lys Lys Lys Glu 
                165                 170                 175     


Pro Tyr Cys Arg Gly Leu Met Ala Ile Asp Cys Pro His Thr Gly Ile 
            180                 185                 190         


Val Asp Tyr Arg Gln Val Ala Leu Ser Phe Ala Gln Asp Phe Gln Glu 
        195                 200                 205             


Ala Gly Gly Ser Val Leu Thr Asn Phe Glu Val Lys Gly Ile Glu Met 
    210                 215                 220                 


Ala Lys Glu Ser Pro Ser Arg Ser Ile Asp Gly Met Gln Tyr Pro Ile 
225                 230                 235                 240 


Val Ile Lys Asn Thr Lys Gly Glu Glu Ile Arg Cys Gln Tyr Val Val 
                245                 250                 255     


Thr Cys Ala Gly Leu Tyr Ser Asp Arg Ile Ser Glu Leu Ser Gly Cys 
            260                 265                 270         


Thr Pro Asp Pro Arg Ile Val Pro Phe Arg Gly Asp Tyr Leu Leu Leu 
        275                 280                 285             


Lys Pro Glu Lys Cys Tyr Leu Val Lys Gly Asn Ile Tyr Pro Val Pro 
    290                 295                 300                 


Asp Ser Arg Phe Pro Phe Leu Gly Val His Phe Thr Pro Arg Met Asp 
305                 310                 315                 320 


Gly Ser Ile Trp Leu Gly Pro Asn Ala Val Leu Ala Phe Lys Arg Glu 
                325                 330                 335     


Gly Tyr Arg Pro Phe Asp Phe Ser Ala Thr Asp Val Met Asp Ile Ile 
            340                 345                 350         


Ile Asn Ser Gly Leu Ile Lys Leu Ala Ser Gln Asn Phe Ser Tyr Gly 
        355                 360                 365             


Val Thr Glu Met Tyr Lys Ala Cys Phe Leu Gly Ala Thr Val Lys Tyr 
    370                 375                 380                 


Leu Gln Lys Phe Ile Pro Glu Ile Thr Ile Ser Asp Ile Leu Arg Gly 
385                 390                 395                 400 


Pro Ala Gly Val Arg Ala Gln Ala Leu Asp Arg Asp Gly Asn Leu Val 
                405                 410                 415     


Glu Asp Phe Val Phe Asp Ala Gly Val Gly Asp Ile Gly Asn Arg Ile 
            420                 425                 430         


Leu His Val Arg Asn Ala Pro Ser Pro Ala Ala Thr Ser Ser Ile Ala 
        435                 440                 445             


Ile Ser Gly Met Ile Ala Asp Glu Val Gln Gln Arg Phe Glu Leu 
    450                 455                 460             


<210>  6060
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L3MBTL1__Homo_sapiens__NP_056293

<400>  6060

Met Arg Arg Arg Glu Gly His Gly Thr Asp Ser Glu Met Gly Gln Gly 
1               5                   10                  15      


Pro Val Arg Glu Ser Gln Ser Ser Asp Pro Pro Ala Leu Gln Phe Arg 
            20                  25                  30          


Ile Ser Glu Tyr Lys Pro Leu Asn Met Ala Gly Val Glu Gln Pro Pro 
        35                  40                  45              


Ser Pro Glu Leu Arg Gln Glu Gly Val Thr Glu Tyr Glu Asp Gly Gly 
    50                  55                  60                  


Ala Pro Ala Gly Asp Gly Glu Ala Gly Pro Gln Gln Ala Glu Asp His 
65                  70                  75                  80  


Pro Gln Asn Pro Pro Glu Asp Pro Asn Gln Asp Pro Pro Glu Asp Asp 
                85                  90                  95      


Ser Thr Cys Gln Cys Gln Ala Cys Gly Pro His Gln Ala Ala Gly Pro 
            100                 105                 110         


Asp Leu Gly Ser Ser Asn Asp Gly Cys Pro Gln Leu Phe Gln Glu Arg 
        115                 120                 125             


Ser Val Ile Val Glu Asn Ser Ser Gly Ser Thr Ser Ala Ser Glu Leu 
    130                 135                 140                 


Leu Lys Pro Met Lys Lys Arg Lys Arg Arg Glu Tyr Gln Ser Pro Ser 
145                 150                 155                 160 


Glu Glu Glu Ser Glu Pro Glu Ala Met Glu Lys Gln Glu Glu Gly Lys 
                165                 170                 175     


Asp Pro Glu Gly Gln Pro Thr Ala Ser Thr Pro Glu Ser Glu Glu Trp 
            180                 185                 190         


Ser Ser Ser Gln Pro Ala Thr Gly Glu Lys Lys Glu Cys Trp Ser Trp 
        195                 200                 205             


Glu Ser Tyr Leu Glu Glu Gln Lys Ala Ile Thr Ala Pro Val Ser Leu 
    210                 215                 220                 


Phe Gln Asp Ser Gln Ala Val Thr His Asn Lys Asn Gly Phe Lys Leu 
225                 230                 235                 240 


Gly Met Lys Leu Glu Gly Ile Asp Pro Gln His Pro Ser Met Tyr Phe 
                245                 250                 255     


Ile Leu Thr Val Ala Glu Val Cys Gly Tyr Arg Leu Arg Leu His Phe 
            260                 265                 270         


Asp Gly Tyr Ser Glu Cys His Asp Phe Trp Val Asn Ala Asn Ser Pro 
        275                 280                 285             


Asp Ile His Pro Ala Gly Trp Phe Glu Lys Thr Gly His Lys Leu Gln 
    290                 295                 300                 


Pro Pro Lys Gly Tyr Lys Glu Glu Glu Phe Ser Trp Ser Gln Tyr Leu 
305                 310                 315                 320 


Arg Ser Thr Arg Ala Gln Ala Ala Pro Lys His Leu Phe Val Ser Gln 
                325                 330                 335     


Ser His Ser Pro Pro Pro Leu Gly Phe Gln Val Gly Met Lys Leu Glu 
            340                 345                 350         


Ala Val Asp Arg Met Asn Pro Ser Leu Val Cys Val Ala Ser Val Thr 
        355                 360                 365             


Asp Val Val Asp Ser Arg Phe Leu Val His Phe Asp Asn Trp Asp Asp 
    370                 375                 380                 


Thr Tyr Asp Tyr Trp Cys Asp Pro Ser Ser Pro Tyr Ile His Pro Val 
385                 390                 395                 400 


Gly Trp Cys Gln Lys Gln Gly Lys Pro Leu Thr Pro Pro Gln Asp Tyr 
                405                 410                 415     


Pro Asp Pro Asp Asn Phe Cys Trp Glu Lys Tyr Leu Glu Glu Thr Gly 
            420                 425                 430         


Ala Ser Ala Val Pro Thr Trp Ala Phe Lys Val Arg Pro Pro His Ser 
        435                 440                 445             


Phe Leu Val Asn Met Lys Leu Glu Ala Val Asp Arg Arg Asn Pro Ala 
    450                 455                 460                 


Leu Ile Arg Val Ala Ser Val Glu Asp Val Glu Asp His Arg Ile Lys 
465                 470                 475                 480 


Ile His Phe Asp Gly Trp Ser His Gly Tyr Asp Phe Trp Ile Asp Ala 
                485                 490                 495     


Asp His Pro Asp Ile His Pro Ala Gly Trp Cys Ser Lys Thr Gly His 
            500                 505                 510         


Pro Leu Gln Pro Pro Leu Gly Pro Arg Glu Pro Ser Ser Ala Ser Pro 
        515                 520                 525             


Gly Gly Cys Pro Pro Leu Ser Tyr Arg Ser Leu Pro His Thr Arg Thr 
    530                 535                 540                 


Ser Lys Tyr Ser Phe His His Arg Lys Cys Pro Thr Pro Gly Cys Asp 
545                 550                 555                 560 


Gly Ser Gly His Val Thr Gly Lys Phe Thr Ala His His Cys Leu Ser 
                565                 570                 575     


Gly Cys Pro Leu Ala Glu Arg Asn Gln Ser Arg Leu Lys Ala Glu Leu 
            580                 585                 590         


Ser Asp Ser Glu Ala Ser Ala Arg Lys Lys Asn Leu Ser Gly Phe Ser 
        595                 600                 605             


Pro Arg Lys Lys Pro Arg His His Gly Arg Ile Gly Arg Pro Pro Lys 
    610                 615                 620                 


Tyr Arg Lys Ile Pro Gln Glu Asp Phe Gln Thr Leu Thr Pro Asp Val 
625                 630                 635                 640 


Val His Gln Ser Leu Phe Met Ser Ala Leu Ser Ala His Pro Asp Arg 
                645                 650                 655     


Ser Leu Ser Val Cys Trp Glu Gln His Cys Lys Leu Leu Pro Gly Val 
            660                 665                 670         


Ala Gly Ile Ser Ala Ser Thr Val Ala Lys Trp Thr Ile Asp Glu Val 
        675                 680                 685             


Phe Gly Phe Val Gln Thr Leu Thr Gly Cys Glu Asp Gln Ala Arg Leu 
    690                 695                 700                 


Phe Lys Asp Glu Ala Arg Ile Val Arg Val Thr His Val Ser Gly Lys 
705                 710                 715                 720 


Thr Leu Val Trp Thr Val Ala Gln Leu Gly Asp Leu Val Cys Ser Asp 
                725                 730                 735     


His Leu Gln Glu Gly Lys Gly Ile Leu Glu Thr Gly Val His Ser Leu 
            740                 745                 750         


Leu Cys Ser Leu Pro Thr His Leu Leu Ala Lys Leu Ser Phe Ala Ser 
        755                 760                 765             


Asp Ser Gln Tyr 
    770         


<210>  6061
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L3MBTL2__Homo_sapiens__NP_113676

<400>  6061

Met Glu Lys Pro Arg Ser Ile Glu Glu Thr Pro Ser Ser Glu Pro Met 
1               5                   10                  15      


Glu Glu Glu Glu Asp Asp Asp Leu Glu Leu Phe Gly Gly Tyr Asp Ser 
            20                  25                  30          


Phe Arg Ser Tyr Asn Ser Ser Val Gly Ser Glu Ser Ser Ser Tyr Leu 
        35                  40                  45              


Glu Glu Ser Ser Glu Ala Glu Asn Glu Asp Arg Glu Ala Gly Glu Leu 
    50                  55                  60                  


Pro Thr Ser Pro Leu His Leu Leu Ser Pro Gly Thr Pro Arg Ser Leu 
65                  70                  75                  80  


Asp Gly Ser Gly Ser Glu Pro Ala Val Cys Glu Met Cys Gly Ile Val 
                85                  90                  95      


Gly Thr Arg Glu Ala Phe Phe Ser Lys Thr Lys Arg Phe Cys Ser Val 
            100                 105                 110         


Ser Cys Ser Arg Ser Tyr Ser Ser Asn Ser Lys Lys Ala Ser Ile Leu 
        115                 120                 125             


Ala Arg Leu Gln Gly Lys Pro Pro Thr Lys Lys Ala Lys Val Leu His 
    130                 135                 140                 


Lys Ala Ala Trp Ser Ala Lys Ile Gly Ala Phe Leu His Ser Gln Gly 
145                 150                 155                 160 


Thr Gly Gln Leu Ala Asp Gly Thr Pro Thr Gly Gln Asp Ala Leu Val 
                165                 170                 175     


Leu Gly Phe Asp Trp Gly Lys Phe Leu Lys Asp His Ser Tyr Lys Ala 
            180                 185                 190         


Ala Pro Val Ser Cys Phe Lys His Val Pro Leu Tyr Asp Gln Trp Glu 
        195                 200                 205             


Asp Val Met Lys Gly Met Lys Val Glu Val Leu Asn Ser Asp Ala Val 
    210                 215                 220                 


Leu Pro Ser Arg Val Tyr Trp Ile Ala Ser Val Ile Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Arg Val Leu Leu Arg Tyr Glu Gly Phe Glu Asn Asp Ala Ser His 
                245                 250                 255     


Asp Phe Trp Cys Asn Leu Gly Thr Val Asp Val His Pro Ile Gly Trp 
            260                 265                 270         


Cys Ala Ile Asn Ser Lys Ile Leu Val Pro Pro Arg Thr Ile His Ala 
        275                 280                 285             


Lys Phe Thr Asp Trp Lys Gly Tyr Leu Met Lys Arg Leu Val Gly Ser 
    290                 295                 300                 


Arg Thr Leu Pro Val Asp Phe His Ile Lys Met Val Glu Ser Met Lys 
305                 310                 315                 320 


Tyr Pro Phe Arg Gln Gly Met Arg Leu Glu Val Val Asp Lys Ser Gln 
                325                 330                 335     


Val Ser Arg Thr Arg Met Ala Val Val Asp Thr Val Ile Gly Gly Arg 
            340                 345                 350         


Leu Arg Leu Leu Tyr Glu Asp Gly Asp Ser Asp Asp Asp Phe Trp Cys 
        355                 360                 365             


His Met Trp Ser Pro Leu Ile His Pro Val Gly Trp Ser Arg Arg Val 
    370                 375                 380                 


Gly His Gly Ile Lys Met Ser Glu Arg Arg Ser Asp Met Ala His His 
385                 390                 395                 400 


Pro Thr Phe Arg Lys Ile Tyr Cys Asp Ala Val Pro Tyr Leu Phe Lys 
                405                 410                 415     


Lys Val Arg Ala Val Tyr Thr Glu Gly Gly Trp Phe Glu Glu Gly Met 
            420                 425                 430         


Lys Leu Glu Ala Ile Asp Pro Leu Asn Leu Gly Asn Ile Cys Val Ala 
        435                 440                 445             


Thr Val Cys Lys Val Leu Leu Asp Gly Tyr Leu Met Ile Cys Val Asp 
    450                 455                 460                 


Gly Gly Pro Ser Thr Asp Gly Leu Asp Trp Phe Cys Tyr His Ala Ser 
465                 470                 475                 480 


Ser His Ala Ile Phe Pro Ala Thr Phe Cys Gln Lys Asn Asp Ile Glu 
                485                 490                 495     


Leu Thr Pro Pro Lys Gly Tyr Glu Ala Gln Thr Phe Asn Trp Glu Asn 
            500                 505                 510         


Tyr Leu Glu Lys Thr Lys Ser Lys Ala Ala Pro Ser Arg Leu Phe Asn 
        515                 520                 525             


Met Asp Cys Pro Asn His Gly Phe Lys Val Gly Met Lys Leu Glu Ala 
    530                 535                 540                 


Val Asp Leu Met Glu Pro Arg Leu Ile Cys Val Ala Thr Val Lys Arg 
545                 550                 555                 560 


Val Val His Arg Leu Leu Ser Ile His Phe Asp Gly Trp Asp Ser Glu 
                565                 570                 575     


Tyr Asp Gln Trp Val Asp Cys Glu Ser Pro Asp Ile Tyr Pro Val Gly 
            580                 585                 590         


Trp Cys Glu Leu Thr Gly Tyr Gln Leu Gln Pro Pro Val Ala Ala Glu 
        595                 600                 605             


Pro Ala Thr Pro Leu Lys Ala Lys Glu Ala Thr Lys Lys Lys Lys Lys 
    610                 615                 620                 


Gln Phe Gly Lys Lys Arg Lys Arg Ile Pro Pro Thr Lys Thr Arg Pro 
625                 630                 635                 640 


Leu Arg Gln Gly Ser Lys Lys Pro Leu Leu Glu Asp Asp Pro Gln Gly 
                645                 650                 655     


Ala Arg Lys Ile Ser Ser Glu Pro Val Pro Gly Glu Ile Ile Ala Val 
            660                 665                 670         


Arg Val Lys Glu Glu His Leu Asp Val Ala Ser Pro Asp Lys Ala Ser 
        675                 680                 685             


Ser Pro Glu Leu Pro Val Ser Val Glu Asn Ile Lys Gln Glu Thr Asp 
    690                 695                 700                 


Asp 
705 


<210>  6062
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L3MBTL3__Homo_sapiens__NP_001007103

<400>  6062

Met Thr Glu Ser Ala Ser Ser Thr Ser Gly Gln Glu Phe Asp Val Phe 
1               5                   10                  15      


Ser Val Met Asp Trp Lys Asp Gly Val Gly Thr Leu Pro Gly Ser Asp 
            20                  25                  30          


Leu Lys Phe Arg Val Asn Glu Phe Gly Ala Leu Glu Val Ile Thr Asp 
        35                  40                  45              


Glu Asn Glu Met Glu Asn Val Lys Lys Ala Thr Ala Thr Thr Thr Trp 
    50                  55                  60                  


Met Val Pro Thr Ala Gln Glu Val Phe Ser Glu Lys Thr Gly Met Pro 
65                  70                  75                  80  


Phe Arg Leu Lys Asp Pro Val Lys Val Glu Gly Leu Gln Phe Cys Glu 
                85                  90                  95      


Asn Cys Cys Gln Tyr Gly Asn Val Asp Glu Cys Leu Ser Gly Gly Asn 
            100                 105                 110         


Tyr Cys Ser Gln Asn Cys Ala Arg His Ile Lys Asp Lys Asp Gln Lys 
        115                 120                 125             


Glu Glu Arg Asp Val Glu Glu Asp Asn Glu Glu Glu Asp Pro Lys Cys 
    130                 135                 140                 


Ser Arg Lys Lys Lys Pro Lys Leu Ser Leu Lys Ala Asp Thr Lys Glu 
145                 150                 155                 160 


Asp Gly Glu Glu Arg Asp Asp Glu Met Glu Asn Lys Gln Asp Val Arg 
                165                 170                 175     


Ile Leu Arg Gly Ser Gln Arg Ala Arg Arg Lys Arg Arg Gly Asp Ser 
            180                 185                 190         


Ala Val Leu Lys Gln Gly Leu Pro Pro Lys Gly Lys Lys Ala Trp Cys 
        195                 200                 205             


Trp Ala Ser Tyr Leu Glu Glu Glu Lys Ala Val Ala Val Pro Ala Lys 
    210                 215                 220                 


Leu Phe Lys Glu His Gln Ser Phe Pro Tyr Asn Lys Asn Gly Phe Lys 
225                 230                 235                 240 


Val Gly Met Lys Leu Glu Gly Val Asp Pro Glu His Gln Ser Val Tyr 
                245                 250                 255     


Cys Val Leu Thr Val Ala Glu Val Cys Gly Tyr Arg Ile Lys Leu His 
            260                 265                 270         


Phe Asp Gly Tyr Ser Asp Cys Tyr Asp Phe Trp Val Asn Ala Asp Ala 
        275                 280                 285             


Leu Asp Ile His Pro Val Gly Trp Cys Glu Lys Thr Gly His Lys Leu 
    290                 295                 300                 


His Pro Pro Lys Gly Tyr Lys Glu Glu Glu Phe Asn Trp Gln Thr Tyr 
305                 310                 315                 320 


Leu Lys Thr Cys Lys Ala Gln Ala Ala Pro Lys Ser Leu Phe Glu Asn 
                325                 330                 335     


Gln Asn Ile Thr Val Ile Pro Ser Gly Phe Arg Val Gly Met Lys Leu 
            340                 345                 350         


Glu Ala Val Asp Lys Lys Asn Pro Ser Phe Ile Cys Val Ala Thr Val 
        355                 360                 365             


Thr Asp Met Val Asp Asn Arg Phe Leu Val His Phe Asp Asn Trp Asp 
    370                 375                 380                 


Glu Ser Tyr Asp Tyr Trp Cys Glu Ala Ser Ser Pro His Ile His Pro 
385                 390                 395                 400 


Val Gly Trp Cys Lys Glu His Arg Arg Thr Leu Ile Thr Pro Pro Gly 
                405                 410                 415     


Tyr Pro Asn Val Lys His Phe Ser Trp Asp Lys Tyr Leu Glu Glu Thr 
            420                 425                 430         


Asn Ser Leu Pro Ala Pro Ala Arg Ala Phe Lys Val Lys Pro Pro His 
        435                 440                 445             


Gly Phe Gln Lys Lys Met Lys Leu Glu Val Val Asp Lys Arg Asn Pro 
    450                 455                 460                 


Met Phe Ile Arg Val Ala Thr Val Ala Asp Thr Asp Asp His Arg Val 
465                 470                 475                 480 


Lys Val His Phe Asp Gly Trp Asn Asn Cys Tyr Asp Tyr Trp Ile Asp 
                485                 490                 495     


Ala Asp Ser Pro Asp Ile His Pro Val Gly Trp Cys Ser Lys Thr Gly 
            500                 505                 510         


His Pro Leu Gln Pro Pro Leu Ser Pro Leu Glu Leu Met Glu Ala Ser 
        515                 520                 525             


Glu His Gly Gly Cys Ser Thr Pro Gly Cys Lys Gly Ile Gly His Phe 
    530                 535                 540                 


Lys Arg Ala Arg His Leu Gly Pro His Ser Ala Ala Asn Cys Pro Tyr 
545                 550                 555                 560 


Ser Glu Ile Asn Leu Asn Lys Asp Arg Ile Phe Pro Asp Arg Leu Ser 
                565                 570                 575     


Gly Glu Met Pro Pro Ala Ser Pro Ser Phe Pro Arg Asn Lys Arg Thr 
            580                 585                 590         


Asp Ala Asn Glu Ser Ser Ser Ser Pro Glu Ile Arg Asp Gln His Ala 
        595                 600                 605             


Asp Asp Val Lys Glu Asp Phe Glu Glu Arg Thr Glu Ser Glu Met Arg 
    610                 615                 620                 


Thr Ser His Glu Ala Arg Gly Ala Arg Glu Glu Pro Thr Val Gln Gln 
625                 630                 635                 640 


Ala Gln Arg Arg Ser Ala Val Phe Leu Ser Phe Lys Ser Pro Ile Pro 
                645                 650                 655     


Cys Leu Pro Leu Arg Trp Glu Gln Gln Ser Lys Leu Leu Pro Thr Val 
            660                 665                 670         


Ala Gly Ile Pro Ala Ser Lys Val Ser Lys Trp Ser Thr Asp Glu Val 
        675                 680                 685             


Ser Glu Phe Ile Gln Ser Leu Pro Gly Cys Glu Glu His Gly Lys Val 
    690                 695                 700                 


Phe Lys Asp Glu Gln Ile Asp Gly Glu Ala Phe Leu Leu Met Thr Gln 
705                 710                 715                 720 


Thr Asp Ile Val Lys Ile Met Ser Ile Lys Leu Gly Pro Ala Leu Lys 
                725                 730                 735     


Ile Phe Asn Ser Ile Leu Met Phe Lys Ala Ala Glu Lys Asn Ser His 
            740                 745                 750         


Asn Glu Leu 
        755 


<210>  6063
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L3MBTL4__Homo_sapiens__NP_775735

<400>  6063

Met Lys Gln Pro Asn Arg Lys Arg Lys Leu Asn Met Asp Ser Lys Glu 
1               5                   10                  15      


Arg Leu Asp Gln Asp Gly Arg Leu Glu Gln Ala Glu Glu Glu Lys Lys 
            20                  25                  30          


Pro Lys Asp Ser Thr Thr Pro Leu Ser His Val Pro Ser Ala Ala Ala 
        35                  40                  45              


Gln Gly Ala Trp Ser Trp Glu Trp Tyr Leu Lys Glu Gln Lys Ala Val 
    50                  55                  60                  


Ala Ala Pro Val Glu Leu Phe Ser Lys Asp Gln Ser Phe Pro Glu His 
65                  70                  75                  80  


Glu Asn Gly Phe Gln Ile Gly Met Arg Leu Glu Gly Ile Asp Pro Arg 
                85                  90                  95      


His Pro Ser Val Phe Cys Val Leu Ser Val Ala Glu Val Cys Gly Tyr 
            100                 105                 110         


Arg Leu Arg Leu His Phe Asp Gly Tyr Leu Ser Cys Tyr Asp Phe Trp 
        115                 120                 125             


Thr Asn Ala Gly Ser Pro Asp Ile His Pro Val Gly Trp Cys Glu Lys 
    130                 135                 140                 


Thr Lys His Glu Leu His Ile Pro Lys Gly Tyr Arg Lys Asp Lys Phe 
145                 150                 155                 160 


Val Trp Met Asp Tyr Leu Lys Ala Cys Lys Leu Gln Asn Ala Pro Lys 
                165                 170                 175     


Lys Leu Phe Arg Asn Arg Ser Pro Asn Gly Pro Met Ser Lys Glu Phe 
            180                 185                 190         


Gln Val Gly Met Lys Leu Glu Ala Val Asp Arg Lys Asn Pro Ser Leu 
        195                 200                 205             


Val Cys Val Ala Thr Ile Ala Asp Ile Val Glu Asp Arg Leu Leu Val 
    210                 215                 220                 


His Phe Asp Asn Trp Asp Asp Ser Tyr Asp Tyr Trp Cys Asp Val Asn 
225                 230                 235                 240 


Ser Pro Tyr Val Gln Pro Val Gly Trp Cys Gln Glu Asn Gly Arg Thr 
                245                 250                 255     


Leu Ile Ala Pro Gln Gly Tyr Pro Asn Pro Glu Asn Phe Ser Trp Thr 
            260                 265                 270         


Glu Tyr Leu Glu Ala Thr Gln Thr Asn Ala Val Pro Ala Lys Val Phe 
        275                 280                 285             


Lys Met Arg Leu Pro His Gly Phe Leu Pro Asn Met Lys Leu Glu Val 
    290                 295                 300                 


Val Asp Lys Arg Asn Pro Arg Leu Ile Arg Val Ala Thr Ile Val Asp 
305                 310                 315                 320 


Val Asp Asp Gln Arg Val Lys Val His Phe Asp Gly Trp Asp His Lys 
                325                 330                 335     


Tyr Asp Tyr Trp Val Glu Ala Asp Ser Pro Asp Ile His Pro Ile Gly 
            340                 345                 350         


Trp Cys Asp Val Thr Gly His Pro Leu Glu Val Pro Gln Arg Thr Asn 
        355                 360                 365             


Asp Leu Lys Ile Leu Pro Gly Gln Ala Val Cys Pro Thr Pro Gly Cys 
    370                 375                 380                 


Arg Gly Ile Gly His Ile Arg Gly Pro Arg Tyr Ser Gly His His Ser 
385                 390                 395                 400 


Ala Phe Gly Cys Pro Tyr Ser Asp Met Asn Leu Lys Lys Glu Ala Thr 
                405                 410                 415     


Leu His Asp Arg Leu Arg Glu Gln Thr Gln Ala Asn Leu Glu Ser Asp 
            420                 425                 430         


Ser Ser His Ser Lys Ser Lys Ser Leu Cys Ser Leu Asn Phe Asn Gly 
        435                 440                 445             


Lys His Glu Lys Val Asn Ser Gln Pro Arg Leu Val Gln Gln Ala Lys 
    450                 455                 460                 


Cys Leu Lys Ile Lys Gly Lys Glu Asp Ile Asp Leu Asp Asn Leu Phe 
465                 470                 475                 480 


Arg Val Leu Val Leu His Pro Arg Gly Leu Glu Tyr Ser Val Glu Gln 
                485                 490                 495     


Ala Gln Gln Val Leu His Gln Ser Val Ser Met Ser Thr Val Ser Ala 
            500                 505                 510         


His Pro Phe Arg Asp Leu Pro Leu Gly Arg Glu Gln His Cys Lys Leu 
        515                 520                 525             


Leu Pro Gly Val Ala Asp Ile Arg Ala Ser Gln Val Ala Arg Trp Thr 
    530                 535                 540                 


Val Asp Glu Val Ala Glu Phe Val Gln Ser Leu Leu Gly Cys Glu Glu 
545                 550                 555                 560 


His Ala Lys Cys Phe Lys Lys Glu Gln Ile Asp Gly Lys Ala Phe Leu 
                565                 570                 575     


Leu Leu Thr Gln Thr Asp Ile Val Lys Val Met Lys Ile Lys Leu Gly 
            580                 585                 590         


Pro Ala Leu Lys Ile Tyr Asn Ser Ile Leu Met Phe Arg His Ser Gln 
        595                 600                 605             


Glu Leu Pro Glu Glu Asp Ile Ala Ser Gly Gln Glu Val Arg Gly 
    610                 615                 620             


<210>  6064
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LACC1__Homo_sapiens__XP_006719829

<400>  6064

Met Ala Glu Ala Val Leu Ile Asp Leu Phe Gly Leu Lys Leu Asn Ser 
1               5                   10                  15      


Gln Lys Asn Cys His Gln Thr Leu Leu Lys Thr Leu Asn Ala Val Gln 
            20                  25                  30          


Tyr His His Ala Ala Lys Ala Lys Phe Leu Cys Ile Met Cys Cys Ser 
        35                  40                  45              


Asn Ile Ser Tyr Glu Arg Asp Gly Glu Gln Asp Asn Cys Glu Ile Glu 
    50                  55                  60                  


Thr Ser Asn Gly Leu Ser Ala Leu Leu Glu Glu Phe Glu Ile Val Ser 
65                  70                  75                  80  


Cys Pro Ser Met Ala Ala Thr Leu Tyr Thr Ile Lys Gln Lys Ile Asp 
                85                  90                  95      


Glu Lys Asn Leu Ser Ser Ile Lys Val Ile Val Pro Arg His Arg Lys 
            100                 105                 110         


Thr Leu Met Lys Ala Phe Ile Asp Gln Leu Phe Thr Asp Val Tyr Asn 
        115                 120                 125             


Phe Glu Phe Glu Asp Leu Gln Val Thr Phe Arg Gly Gly Leu Phe Lys 
    130                 135                 140                 


Gln Ser Ile Glu Ile Asn Val Ile Thr Ala Gln Glu Leu Arg Gly Ile 
145                 150                 155                 160 


Gln Asn Glu Ile Glu Thr Phe Leu Arg Ser Leu Pro Ala Leu Arg Gly 
                165                 170                 175     


Lys Leu Thr Ile Ile Thr Ser Ser Leu Ile Pro Asp Ile Phe Ile His 
            180                 185                 190         


Gly Phe Thr Thr Arg Thr Gly Gly Ile Ser Tyr Ile Pro Thr Leu Ser 
        195                 200                 205             


Ser Phe Asn Leu Phe Ser Ser Ser Lys Arg Arg Asp Pro Lys Val Val 
    210                 215                 220                 


Val Gln Glu Asn Leu Arg Arg Leu Ala Asn Ala Ala Gly Phe Asn Val 
225                 230                 235                 240 


Glu Lys Phe Tyr Arg Ile Lys Thr His His Ser Asn Asp Ile Trp Ile 
                245                 250                 255     


Met Gly Arg Lys Glu Pro Asp Ser Tyr Asp Gly Ile Thr Thr Asn Gln 
            260                 265                 270         


Arg Gly Val Thr Ile Ala Ala Leu Gly Ala Asp Cys Ile Pro Ile Val 
        275                 280                 285             


Phe Ala Asp Pro Val Lys Lys Ala Cys Gly Val Ala His Ala Gly Trp 
    290                 295                 300                 


Lys Gly Thr Leu Leu Gly Val Ala Met Ala Thr Val Asn Ala Met Ile 
305                 310                 315                 320 


Ala Glu Tyr Gly Cys Ser Leu Glu Asp Ile Val Val Val Leu Gly Pro 
                325                 330                 335     


Ser Val Gly Pro Cys Cys Phe Thr Leu Pro Arg Glu Ser Ala Glu Ala 
            340                 345                 350         


Phe His Asn Leu His Pro Ala Cys Val Gln Leu Phe Asp Ser Pro Asn 
        355                 360                 365             


Pro Cys Ile Asp Ile Arg Lys Ala Thr Arg Ile Leu Leu Glu Gln Gly 
    370                 375                 380                 


Gly Ile Leu Pro Gln Asn Ile Gln Asp Gln Asn Gln Asp Leu Asn Leu 
385                 390                 395                 400 


Cys Thr Ser Cys His Pro Asp Lys Phe Phe Ser His Val Arg Asp Gly 
                405                 410                 415     


Leu Asn Phe Gly Thr Gln Ile Gly Phe Ile Ser Ile Lys Glu 
            420                 425                 430 


<210>  6065
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LACE1__Homo_sapiens__NP_660358

<400>  6065

Met Ala Ala Ser Trp Ser Leu Leu Val Thr Leu Arg Pro Leu Ala Gln 
1               5                   10                  15      


Ser Pro Leu Arg Gly Arg Cys Val Gly Cys Gly Ala Trp Ala Ala Ala 
            20                  25                  30          


Leu Ala Pro Leu Ala Thr Ala Pro Gly Lys Pro Phe Trp Lys Ala Tyr 
        35                  40                  45              


Thr Val Gln Thr Ser Glu Ser Met Thr Pro Thr Ala Thr Ser Glu Thr 
    50                  55                  60                  


Tyr Leu Lys Ala Leu Ala Val Cys His Gly Pro Leu Asp His Tyr Asp 
65                  70                  75                  80  


Phe Leu Ile Lys Ala His Glu Leu Lys Asp Asp Glu His Gln Arg Arg 
                85                  90                  95      


Val Ile Gln Cys Leu Gln Lys Leu His Glu Asp Leu Lys Gly Tyr Asn 
            100                 105                 110         


Ile Glu Ala Glu Gly Leu Phe Ser Lys Leu Phe Ser Arg Ser Lys Pro 
        115                 120                 125             


Pro Arg Gly Leu Tyr Val Tyr Gly Asp Val Gly Thr Gly Lys Thr Met 
    130                 135                 140                 


Val Met Asp Met Phe Tyr Ala Tyr Val Glu Met Lys Arg Lys Lys Arg 
145                 150                 155                 160 


Val His Phe His Gly Phe Met Leu Asp Val His Lys Arg Ile His Arg 
                165                 170                 175     


Leu Lys Gln Ser Leu Pro Lys Arg Lys Pro Gly Phe Met Ala Lys Ser 
            180                 185                 190         


Tyr Asp Pro Ile Ala Pro Ile Ala Glu Glu Ile Ser Glu Glu Ala Cys 
        195                 200                 205             


Leu Leu Cys Phe Asp Glu Phe Gln Val Thr Asp Ile Ala Asp Ala Met 
    210                 215                 220                 


Ile Leu Lys Gln Leu Phe Glu Asn Leu Phe Lys Asn Gly Val Val Val 
225                 230                 235                 240 


Val Ala Thr Ser Asn Arg Pro Pro Glu Asp Leu Tyr Lys Asn Gly Leu 
                245                 250                 255     


Gln Arg Ala Asn Phe Val Pro Phe Ile Ala Val Leu Lys Glu Tyr Cys 
            260                 265                 270         


Asn Thr Val Gln Leu Asp Ser Gly Ile Asp Tyr Arg Lys Arg Glu Leu 
        275                 280                 285             


Pro Ala Ala Gly Lys Leu Tyr Tyr Leu Thr Ser Glu Ala Asp Val Glu 
    290                 295                 300                 


Ala Val Met Asp Lys Leu Phe Asp Glu Leu Ala Gln Lys Gln Asn Asp 
305                 310                 315                 320 


Leu Thr Arg Pro Arg Ile Leu Lys Val Gln Gly Arg Glu Leu Arg Leu 
                325                 330                 335     


Asn Lys Ala Cys Gly Thr Val Ala Asp Cys Thr Phe Glu Glu Leu Cys 
            340                 345                 350         


Glu Arg Pro Leu Gly Ala Ser Asp Tyr Leu Glu Leu Ser Lys Asn Phe 
        355                 360                 365             


Asp Thr Ile Phe Leu Arg Asn Ile Pro Gln Phe Thr Leu Ala Asn Arg 
    370                 375                 380                 


Thr Gln Gly Arg Arg Phe Ile Thr Leu Ile Asp Asn Phe Tyr Asp Leu 
385                 390                 395                 400 


Lys Val Arg Ile Ile Cys Ser Ala Ser Thr Pro Ile Ser Ser Leu Phe 
                405                 410                 415     


Leu His Gln His His Asp Ser Glu Leu Glu Gln Ser Arg Ile Leu Met 
            420                 425                 430         


Asp Asp Leu Gly Leu Ser Gln Asp Ser Ala Glu Gly Leu Ser Met Phe 
        435                 440                 445             


Thr Gly Glu Glu Glu Ile Phe Ala Phe Gln Arg Thr Ile Ser Arg Leu 
    450                 455                 460                 


Thr Glu Met Gln Thr Glu Gln Tyr Trp Asn Glu Gly Asp Arg Thr Lys 
465                 470                 475                 480 


Lys 
    


<210>  6066
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LACRT__Homo_sapiens__NP_150593

<400>  6066

Met Lys Phe Thr Thr Leu Leu Phe Leu Ala Ala Val Ala Gly Ala Leu 
1               5                   10                  15      


Val Tyr Ala Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala 
            20                  25                  30          


Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala 
        35                  40                  45              


Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser 
    50                  55                  60                  


Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Asn Pro Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu 
                85                  90                  95      


Gln Ala Leu Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
        115                 120                 125             


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
    130                 135             


<210>  6067
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LACTB__Homo_sapiens__NP_116246

<400>  6067

Met Tyr Arg Leu Met Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Gly 
1               5                   10                  15      


Gly Leu Ala Ser Ser Cys Gly Arg Arg Gly Val His Gln Arg Ala Gly 
            20                  25                  30          


Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu 
        35                  40                  45              


Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Arg Gly Ala Ala 
    50                  55                  60                  


Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala 
65                  70                  75                  80  


Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro 
                85                  90                  95      


Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg 
            100                 105                 110         


Asp Leu Leu His Arg Ile Lys Asp Glu Val Gly Ala Pro Gly Ile Val 
        115                 120                 125             


Val Gly Val Ser Val Asp Gly Lys Glu Val Trp Ser Glu Gly Leu Gly 
    130                 135                 140                 


Tyr Ala Asp Val Glu Asn Arg Val Pro Cys Lys Pro Glu Thr Val Met 
145                 150                 155                 160 


Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala Lys 
                165                 170                 175     


Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His Tyr 
            180                 185                 190         


Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser Val 
        195                 200                 205             


Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr Glu 
    210                 215                 220                 


Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu Lys 
225                 230                 235                 240 


Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys Ser 
                245                 250                 255     


Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn Glu 
            260                 265                 270         


Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn Asp Phe Glu 
        275                 280                 285             


Gln Gly Glu Leu Tyr Leu Arg Glu Lys Phe Glu Asn Ser Ile Glu Ser 
    290                 295                 300                 


Leu Arg Leu Phe Lys Asn Asp Pro Leu Phe Phe Lys Pro Gly Ser Gln 
305                 310                 315                 320 


Phe Leu Tyr Ser Thr Phe Gly Tyr Thr Leu Leu Ala Ala Ile Val Glu 
                325                 330                 335     


Arg Ala Ser Gly Cys Lys Tyr Leu Asp Tyr Met Gln Lys Ile Phe His 
            340                 345                 350         


Asp Leu Asp Met Leu Thr Thr Val Gln Glu Glu Asn Glu Pro Val Ile 
        355                 360                 365             


Tyr Asn Arg Ala Arg Phe Tyr Val Tyr Asn Lys Lys Lys Arg Leu Val 
    370                 375                 380                 


Asn Thr Pro Tyr Val Asp Asn Ser Tyr Lys Trp Ala Gly Gly Gly Phe 
385                 390                 395                 400 


Leu Ser Thr Val Gly Asp Leu Leu Lys Phe Gly Asn Ala Met Leu Tyr 
                405                 410                 415     


Gly Tyr Gln Val Gly Leu Phe Lys Asn Ser Asn Glu Asn Leu Leu Pro 
            420                 425                 430         


Gly Tyr Leu Lys Pro Glu Thr Met Val Met Met Trp Thr Pro Val Pro 
        435                 440                 445             


Asn Thr Glu Met Ser Trp Asp Lys Glu Gly Lys Tyr Ala Met Ala Trp 
    450                 455                 460                 


Gly Val Val Glu Arg Lys Gln Thr Tyr Gly Ser Cys Arg Lys Gln Arg 
465                 470                 475                 480 


His Tyr Ala Ser His Thr Gly Gly Ala Val Gly Ala Ser Ser Val Leu 
                485                 490                 495     


Leu Val Leu Pro Glu Glu Leu Asp Thr Glu Thr Ile Asn Asn Lys Val 
            500                 505                 510         


Pro Pro Arg Gly Ile Ile Val Ser Ile Ile Cys Asn Met Gln Ser Val 
        515                 520                 525             


Gly Leu Asn Ser Thr Ala Leu Lys Ile Ala Leu Glu Phe Asp Lys Asp 
    530                 535                 540                 


Arg Ser Asp 
545         


<210>  6068
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAD1__Homo_sapiens__NP_005549

<400>  6068

Met Ala Val Ser Arg Lys Asp Trp Ser Ala Leu Ser Ser Leu Ala Arg 
1               5                   10                  15      


Gln Arg Thr Leu Glu Asp Glu Glu Glu Gln Glu Arg Glu Arg Arg Arg 
            20                  25                  30          


Arg His Arg Asn Leu Ser Ser Thr Thr Asp Asp Glu Ala Pro Arg Leu 
        35                  40                  45              


Ser Gln Asn Gly Asp Arg Gln Ala Ser Ala Ser Glu Arg Leu Pro Ser 
    50                  55                  60                  


Val Glu Glu Ala Glu Val Pro Lys Pro Leu Pro Pro Ala Ser Lys Asp 
65                  70                  75                  80  


Glu Asp Glu Asp Ile Gln Ser Ile Leu Arg Thr Arg Gln Glu Arg Arg 
                85                  90                  95      


Gln Arg Arg Gln Val Val Glu Ala Ala Gln Ala Pro Ile Gln Glu Arg 
            100                 105                 110         


Leu Glu Ala Glu Glu Gly Arg Asn Ser Leu Ser Pro Val Gln Ala Thr 
        115                 120                 125             


Gln Lys Pro Leu Val Ser Lys Lys Glu Leu Glu Ile Pro Pro Arg Arg 
    130                 135                 140                 


Arg Leu Ser Arg Glu Gln Arg Gly Pro Trp Ala Leu Glu Glu Glu Ser 
145                 150                 155                 160 


Leu Val Gly Arg Glu Pro Glu Glu Arg Lys Lys Gly Val Pro Glu Lys 
                165                 170                 175     


Ser Pro Val Leu Glu Lys Ser Ser Met Pro Lys Lys Thr Ala Pro Glu 
            180                 185                 190         


Lys Ser Leu Val Ser Asp Lys Thr Ser Ile Ser Glu Lys Val Leu Ala 
        195                 200                 205             


Ser Glu Lys Thr Ser Leu Ser Glu Lys Ile Ala Val Ser Glu Lys Arg 
    210                 215                 220                 


Asn Ser Ser Glu Lys Lys Ser Val Leu Glu Lys Thr Ser Val Ser Glu 
225                 230                 235                 240 


Lys Ser Leu Ala Pro Gly Met Ala Leu Gly Ser Gly Arg Arg Leu Val 
                245                 250                 255     


Ser Glu Lys Ala Ser Ile Phe Glu Lys Ala Leu Ala Ser Glu Lys Ser 
            260                 265                 270         


Pro Thr Ala Asp Ala Lys Pro Ala Pro Lys Arg Ala Thr Ala Ser Glu 
        275                 280                 285             


Gln Pro Leu Ala Gln Glu Pro Pro Ala Ser Gly Gly Ser Pro Ala Thr 
    290                 295                 300                 


Thr Lys Glu Gln Arg Gly Arg Ala Leu Pro Gly Lys Asn Leu Pro Ser 
305                 310                 315                 320 


Leu Ala Lys Gln Gly Ala Ser Asp Pro Pro Thr Val Ala Ser Arg Leu 
                325                 330                 335     


Pro Pro Val Thr Leu Gln Val Lys Ile Pro Ser Lys Glu Glu Glu Ala 
            340                 345                 350         


Asp Met Ser Ser Pro Thr Gln Arg Thr Tyr Ser Ser Ser Leu Lys Arg 
        355                 360                 365             


Ser Ser Pro Arg Thr Ile Ser Phe Arg Met Lys Pro Lys Lys Glu Asn 
    370                 375                 380                 


Ser Glu Thr Thr Leu Thr Arg Ser Ala Ser Met Lys Leu Pro Asp Asn 
385                 390                 395                 400 


Thr Val Lys Leu Gly Glu Lys Leu Glu Arg Tyr His Thr Ala Ile Arg 
                405                 410                 415     


Arg Ser Glu Ser Val Lys Ser Arg Gly Leu Pro Cys Thr Glu Leu Phe 
            420                 425                 430         


Val Ala Pro Val Gly Val Ala Ser Lys Arg His Leu Phe Glu Lys Glu 
        435                 440                 445             


Leu Ala Gly Gln Ser Arg Ala Glu Pro Ala Ser Ser Arg Lys Glu Asn 
    450                 455                 460                 


Leu Arg Leu Ser Gly Val Val Thr Ser Arg Leu Asn Leu Trp Ile Ser 
465                 470                 475                 480 


Arg Thr Gln Glu Ser Gly Asp Gln Asp Pro Gln Glu Ala Gln Lys Ala 
                485                 490                 495     


Ser Ser Ala Thr Glu Arg Thr Gln Trp Gly Gln Lys Ser Asp Ser Ser 
            500                 505                 510         


Leu Asp Ala Glu Val 
        515         


<210>  6069
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAG3__Homo_sapiens__NP_002277

<400>  6069

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  6070
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAIR1__Homo_sapiens__NP_001275955

<400>  6070

Met Glu Arg Glu Met Val Leu Cys Leu Ala Gln Thr Ile His Thr Gln 
1               5                   10                  15      


Glu Asp Leu Pro Arg Pro Ser Ile Ser Ala Glu Pro Gly Thr Val Ile 
            20                  25                  30          


Pro Leu Gly Ser His Val Thr Phe Val Cys Arg Gly Pro Val Gly Val 
        35                  40                  45              


Gln Thr Phe Arg Leu Glu Arg Asp Ser Arg Ser Thr Tyr Asn Asp Thr 
    50                  55                  60                  


Glu Asp Val Ser Gln Ala Ser Pro Ser Glu Ser Glu Ala Arg Phe Arg 
65                  70                  75                  80  


Ile Asp Ser Val Arg Glu Gly Asn Ala Gly Leu Tyr Arg Cys Ile Tyr 
                85                  90                  95      


Tyr Lys Pro Pro Lys Trp Ser Glu Gln Ser Asp Tyr Leu Glu Leu Leu 
            100                 105                 110         


Val Lys Glu Ser Ser Gly Gly Pro Asp Ser Pro Asp Thr Glu Pro Gly 
        115                 120                 125             


Ser Ser Ala Gly Pro Thr Gln Arg Pro Ser Asp Asn Ser His Asn Glu 
    130                 135                 140                 


His Ala Pro Ala Ser Gln Gly Leu Lys Ala Glu His Leu Tyr Ile Leu 
145                 150                 155                 160 


Ile Gly Val Ser Val Val Phe Leu Phe Cys Leu Leu Leu Leu Val Leu 
                165                 170                 175     


Phe Cys Leu His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser 
            180                 185                 190         


Lys Asp Glu Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp 
        195                 200                 205             


Val Leu Glu Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu 
    210                 215                 220                 


Lys Asp Arg Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln 
225                 230                 235                 240 


Glu Val Thr Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr 
                245                 250                 255     


Ala Arg Ala Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile 
            260                 265                 270         


Thr Tyr Ala Ala Val Ala Arg His 
        275                 280 


<210>  6071
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAIR2__Homo_sapiens__NP_002279

<400>  6071

Met Ser Pro His Leu Thr Ala Leu Leu Gly Leu Val Leu Cys Leu Ala 
1               5                   10                  15      


Gln Thr Ile His Thr Gln Glu Gly Ala Leu Pro Arg Pro Ser Ile Ser 
            20                  25                  30          


Ala Glu Pro Gly Thr Val Ile Ser Pro Gly Ser His Val Thr Phe Met 
        35                  40                  45              


Cys Arg Gly Pro Val Gly Val Gln Thr Phe Arg Leu Glu Arg Glu Asp 
    50                  55                  60                  


Arg Ala Lys Tyr Lys Asp Ser Tyr Asn Val Phe Arg Leu Gly Pro Ser 
65                  70                  75                  80  


Glu Ser Glu Ala Arg Phe His Ile Asp Ser Val Ser Glu Gly Asn Ala 
                85                  90                  95      


Gly Leu Tyr Arg Cys Leu Tyr Tyr Lys Pro Pro Gly Trp Ser Glu His 
            100                 105                 110         


Ser Asp Phe Leu Glu Leu Leu Val Lys Glu Ser Ser Gly Gly Pro Asp 
        115                 120                 125             


Ser Pro Asp Thr Glu Pro Gly Ser Ser Ala Gly Thr Val Pro Gly Thr 
    130                 135                 140                 


Glu Ala Ser Gly Phe Asp Ala Pro 
145                 150         


<210>  6072
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LALBA__Homo_sapiens__XP_011536644

<400>  6072

Met Glu Asp Leu Gln Phe Leu Gly Val Ala Lys Met Arg Phe Phe Val 
1               5                   10                  15      


Pro Leu Phe Leu Val Gly Ile Leu Phe Pro Ala Ile Leu Ala Lys Gln 
            20                  25                  30          


Phe Thr Lys Cys Glu Leu Ser Gln Leu Leu Lys Asp Ile Asp Gly Tyr 
        35                  40                  45              


Gly Gly Ile Ala Leu Pro Glu Leu Ile Cys Thr Met Phe His Thr Ser 
    50                  55                  60                  


Gly Tyr Asp Thr Gln Ala Ile Val Glu Asn Asn Glu Ser Thr Glu Tyr 
65                  70                  75                  80  


Gly Leu Phe Gln Ile Ser Asn Lys Leu Trp Cys Lys Ser Ser Gln Val 
                85                  90                  95      


Pro Gln Ser Arg Asn Ile Cys Asp Ile Ser Cys Asp Lys Phe Leu Asp 
            100                 105                 110         


Asp Asp Ile Thr Asp Asp Ile Met Cys Ala Lys Lys Ile Leu Asp Ile 
        115                 120                 125             


Lys Gly Ile Asp Tyr Trp Leu Ala His Lys Ala Leu Cys Thr Glu Lys 
    130                 135                 140                 


Leu Glu Gln Trp Leu Cys Glu Lys Leu 
145                 150             


<210>  6073
<211>  3075
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMA1__Homo_sapiens__NP_005550

<400>  6073

Met Arg Gly Gly Val Leu Leu Val Leu Leu Leu Cys Val Ala Ala Gln 
1               5                   10                  15      


Cys Arg Gln Arg Gly Leu Phe Pro Ala Ile Leu Asn Leu Ala Ser Asn 
            20                  25                  30          


Ala His Ile Ser Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu Met 
        35                  40                  45              


Phe Cys Lys Leu Val Glu His Val Pro Gly Arg Pro Val Arg Asn Pro 
    50                  55                  60                  


Gln Cys Arg Ile Cys Asp Gly Asn Ser Ala Asn Pro Arg Glu Arg His 
65                  70                  75                  80  


Pro Ile Ser His Ala Ile Asp Gly Thr Asn Asn Trp Trp Gln Ser Pro 
                85                  90                  95      


Ser Ile Gln Asn Gly Arg Glu Tyr His Trp Val Thr Ile Thr Leu Asp 
            100                 105                 110         


Leu Arg Gln Val Phe Gln Val Ala Tyr Val Ile Ile Lys Ala Ala Asn 
        115                 120                 125             


Ala Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Gly Thr 
    130                 135                 140                 


Thr Phe Ser Pro Trp Gln Tyr Tyr Ala Val Ser Asp Ser Glu Cys Leu 
145                 150                 155                 160 


Ser Arg Tyr Asn Ile Thr Pro Arg Arg Gly Pro Pro Thr Tyr Arg Ala 
                165                 170                 175     


Asp Asp Glu Val Ile Cys Thr Ser Tyr Tyr Ser Arg Leu Val Pro Leu 
            180                 185                 190         


Glu His Gly Glu Ile His Thr Ser Leu Ile Asn Gly Arg Pro Ser Ala 
        195                 200                 205             


Asp Asp Leu Ser Pro Lys Leu Leu Glu Phe Thr Ser Ala Arg Tyr Ile 
    210                 215                 220                 


Arg Leu Arg Leu Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met Thr 
225                 230                 235                 240 


Leu Ser His Arg Glu Pro Lys Glu Leu Asp Pro Ile Val Thr Arg Arg 
                245                 250                 255     


Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser Val Gly Gly Met Cys Ile Cys 
            260                 265                 270         


Tyr Gly His Ala Ser Ser Cys Pro Trp Asp Glu Thr Thr Lys Lys Leu 
        275                 280                 285             


Gln Cys Gln Cys Glu His Asn Thr Cys Gly Glu Ser Cys Asn Arg Cys 
    290                 295                 300                 


Cys Pro Gly Tyr His Gln Gln Pro Trp Arg Pro Gly Thr Val Ser Ser 
305                 310                 315                 320 


Gly Asn Thr Cys Glu Ala Cys Asn Cys His Asn Lys Ala Lys Asp Cys 
                325                 330                 335     


Tyr Tyr Asp Glu Ser Val Ala Lys Gln Lys Lys Ser Leu Asn Thr Ala 
            340                 345                 350         


Gly Gln Phe Arg Gly Gly Gly Val Cys Ile Asn Cys Leu Gln Asn Thr 
        355                 360                 365             


Met Gly Ile Asn Cys Glu Thr Cys Ile Asp Gly Tyr Tyr Arg Pro His 
    370                 375                 380                 


Lys Val Ser Pro Tyr Glu Asp Glu Pro Cys Arg Pro Cys Asn Cys Asp 
385                 390                 395                 400 


Pro Val Gly Ser Leu Ser Ser Val Cys Ile Lys Asp Asp Leu His Ser 
                405                 410                 415     


Asp Leu His Asn Gly Lys Gln Pro Gly Gln Cys Pro Cys Lys Glu Gly 
            420                 425                 430         


Tyr Thr Gly Glu Lys Cys Asp Arg Cys Gln Leu Gly Tyr Lys Asp Tyr 
        435                 440                 445             


Pro Thr Cys Val Ser Cys Gly Cys Asn Pro Val Gly Ser Ala Ser Asp 
    450                 455                 460                 


Glu Pro Cys Thr Gly Pro Cys Val Cys Lys Glu Asn Val Glu Gly Lys 
465                 470                 475                 480 


Ala Cys Asp Arg Cys Lys Pro Gly Phe Tyr Asn Leu Lys Glu Lys Asn 
                485                 490                 495     


Pro Arg Gly Cys Ser Glu Cys Phe Cys Phe Gly Val Ser Asp Val Cys 
            500                 505                 510         


Ser Ser Leu Ser Trp Pro Val Gly Gln Val Asn Ser Met Ser Gly Trp 
        515                 520                 525             


Leu Val Thr Asp Leu Ile Ser Pro Arg Lys Ile Pro Ser Gln Gln Asp 
    530                 535                 540                 


Ala Leu Gly Gly Arg His Gln Val Ser Ile Asn Asn Thr Ala Val Met 
545                 550                 555                 560 


Gln Arg Leu Ala Pro Lys Tyr Tyr Trp Ala Ala Pro Glu Ala Tyr Leu 
                565                 570                 575     


Gly Asn Lys Leu Thr Ala Phe Gly Gly Phe Leu Lys Tyr Thr Val Ser 
            580                 585                 590         


Tyr Asp Ile Pro Val Glu Thr Val Asp Ser Asn Leu Met Ser His Ala 
        595                 600                 605             


Asp Val Ile Ile Lys Gly Asn Gly Leu Thr Leu Ser Thr Gln Ala Glu 
    610                 615                 620                 


Gly Leu Ser Leu Gln Pro Tyr Glu Glu Tyr Leu Asn Val Val Arg Leu 
625                 630                 635                 640 


Val Pro Glu Asn Phe Gln Asp Phe His Ser Lys Arg Gln Ile Asp Arg 
                645                 650                 655     


Asp Gln Leu Met Thr Val Leu Ala Asn Val Thr His Leu Leu Ile Arg 
            660                 665                 670         


Ala Asn Tyr Asn Ser Ala Lys Met Ala Leu Tyr Arg Leu Glu Ser Val 
        675                 680                 685             


Ser Leu Asp Ile Ala Ser Ser Asn Ala Ile Asp Leu Val Val Ala Ala 
    690                 695                 700                 


Asp Val Glu His Cys Glu Cys Pro Gln Gly Tyr Thr Gly Thr Ser Cys 
705                 710                 715                 720 


Glu Ser Cys Leu Ser Gly Tyr Tyr Arg Val Asp Gly Ile Leu Phe Gly 
                725                 730                 735     


Gly Ile Cys Gln Pro Cys Glu Cys His Gly His Ala Ala Glu Cys Asn 
            740                 745                 750         


Val His Gly Val Cys Ile Ala Cys Ala His Asn Thr Thr Gly Val His 
        755                 760                 765             


Cys Glu Gln Cys Leu Pro Gly Phe Tyr Gly Glu Pro Ser Arg Gly Thr 
    770                 775                 780                 


Pro Gly Asp Cys Gln Pro Cys Ala Cys Pro Leu Thr Ile Ala Ser Asn 
785                 790                 795                 800 


Asn Phe Ser Pro Thr Cys His Leu Asn Asp Gly Asp Glu Val Val Cys 
                805                 810                 815     


Asp Trp Cys Ala Pro Gly Tyr Ser Gly Ala Trp Cys Glu Arg Cys Ala 
            820                 825                 830         


Asp Gly Tyr Tyr Gly Asn Pro Thr Val Pro Gly Glu Ser Cys Val Pro 
        835                 840                 845             


Cys Asp Cys Ser Gly Asn Val Asp Pro Ser Glu Ala Gly His Cys Asp 
    850                 855                 860                 


Ser Val Thr Gly Glu Cys Leu Lys Cys Leu Gly Asn Thr Asp Gly Ala 
865                 870                 875                 880 


His Cys Glu Arg Cys Ala Asp Gly Phe Tyr Gly Asp Ala Val Thr Ala 
                885                 890                 895     


Lys Asn Cys Arg Ala Cys Glu Cys His Val Lys Gly Ser His Ser Ala 
            900                 905                 910         


Val Cys His Leu Glu Thr Gly Leu Cys Asp Cys Lys Pro Asn Val Thr 
        915                 920                 925             


Gly Gln Gln Cys Asp Gln Cys Leu His Gly Tyr Tyr Gly Leu Asp Ser 
    930                 935                 940                 


Gly His Gly Cys Arg Pro Cys Asn Cys Ser Val Ala Gly Ser Val Ser 
945                 950                 955                 960 


Asp Gly Cys Thr Asp Glu Gly Gln Cys His Cys Val Pro Gly Val Ala 
                965                 970                 975     


Gly Lys Arg Cys Asp Arg Cys Ala His Gly Phe Tyr Ala Tyr Gln Asp 
            980                 985                 990         


Gly Ser Cys Thr Pro Cys Asp Cys  Pro His Thr Gln Asn  Thr Cys Asp 
        995                 1000                 1005             


Pro Glu  Thr Gly Glu Cys Val  Cys Pro Pro His Thr  Gln Gly Val 
    1010                 1015                 1020             


Lys Cys  Glu Glu Cys Glu Asp  Gly His Trp Gly Tyr  Asp Ala Glu 
    1025                 1030                 1035             


Val Gly  Cys Gln Ala Cys Asn  Cys Ser Leu Val Gly  Ser Thr His 
    1040                 1045                 1050             


His Arg  Cys Asp Val Val Thr  Gly His Cys Gln Cys  Lys Ser Lys 
    1055                 1060                 1065             


Phe Gly  Gly Arg Ala Cys Asp  Gln Cys Ser Leu Gly  Tyr Arg Asp 
    1070                 1075                 1080             


Phe Pro  Asp Cys Val Pro Cys  Asp Cys Asp Leu Arg  Gly Thr Ser 
    1085                 1090                 1095             


Gly Asp  Ala Cys Asn Leu Glu  Gln Gly Leu Cys Gly  Cys Val Glu 
    1100                 1105                 1110             


Glu Thr  Gly Ala Cys Pro Cys  Lys Glu Asn Val Phe  Gly Pro Gln 
    1115                 1120                 1125             


Cys Asn  Glu Cys Arg Glu Gly  Thr Phe Ala Leu Arg  Ala Asp Asn 
    1130                 1135                 1140             


Pro Leu  Gly Cys Ser Pro Cys  Phe Cys Ser Gly Leu  Ser His Leu 
    1145                 1150                 1155             


Cys Ser  Glu Leu Glu Asp Tyr  Val Arg Thr Pro Val  Thr Leu Gly 
    1160                 1165                 1170             


Ser Asp  Gln Pro Leu Leu Arg  Val Val Ser Gln Ser  Asn Leu Arg 
    1175                 1180                 1185             


Gly Thr  Thr Glu Gly Val Tyr  Tyr Gln Ala Pro Asp  Phe Leu Leu 
    1190                 1195                 1200             


Asp Ala  Ala Thr Val Arg Gln  His Ile Arg Ala Glu  Pro Phe Tyr 
    1205                 1210                 1215             


Trp Arg  Leu Pro Gln Gln Phe  Gln Gly Asp Gln Leu  Met Ala Tyr 
    1220                 1225                 1230             


Gly Gly  Lys Leu Lys Tyr Ser  Val Ala Phe Tyr Ser  Leu Asp Gly 
    1235                 1240                 1245             


Val Gly  Thr Ser Asn Phe Glu  Pro Gln Val Leu Ile  Lys Gly Gly 
    1250                 1255                 1260             


Arg Ile  Arg Lys Gln Val Ile  Tyr Met Asp Ala Pro  Ala Pro Glu 
    1265                 1270                 1275             


Asn Gly  Val Arg Gln Glu Gln  Glu Val Ala Met Arg  Glu Asn Phe 
    1280                 1285                 1290             


Trp Lys  Tyr Phe Asn Ser Val  Ser Glu Lys Pro Val  Thr Arg Glu 
    1295                 1300                 1305             


Asp Phe  Met Ser Val Leu Ser  Asp Ile Glu Tyr Ile  Leu Ile Lys 
    1310                 1315                 1320             


Ala Ser  Tyr Gly Gln Gly Leu  Gln Gln Ser Arg Ile  Ser Asp Ile 
    1325                 1330                 1335             


Ser Met  Glu Val Gly Arg Lys  Ala Glu Lys Leu His  Pro Glu Glu 
    1340                 1345                 1350             


Glu Val  Ala Ser Leu Leu Glu  Asn Cys Val Cys Pro  Pro Gly Thr 
    1355                 1360                 1365             


Val Gly  Phe Ser Cys Gln Asp  Cys Ala Pro Gly Tyr  His Arg Gly 
    1370                 1375                 1380             


Lys Leu  Pro Ala Gly Ser Asp  Arg Gly Pro Arg Pro  Leu Val Ala 
    1385                 1390                 1395             


Pro Cys  Val Pro Cys Ser Cys  Asn Asn His Ser Asp  Thr Cys Asp 
    1400                 1405                 1410             


Pro Asn  Thr Gly Lys Cys Leu  Asn Cys Gly Asp Asn  Thr Ala Gly 
    1415                 1420                 1425             


Asp His  Cys Asp Val Cys Thr  Ser Gly Tyr Tyr Gly  Lys Val Thr 
    1430                 1435                 1440             


Gly Ser  Ala Ser Asp Cys Ala  Leu Cys Ala Cys Pro  His Ser Pro 
    1445                 1450                 1455             


Pro Ala  Ser Phe Ser Pro Thr  Cys Val Leu Glu Gly  Asp His Asp 
    1460                 1465                 1470             


Phe Arg  Cys Asp Ala Cys Leu  Leu Gly Tyr Glu Gly  Lys His Cys 
    1475                 1480                 1485             


Glu Arg  Cys Ser Ser Ser Tyr  Tyr Gly Asn Pro Gln  Thr Pro Gly 
    1490                 1495                 1500             


Gly Ser  Cys Gln Lys Cys Asp  Cys Asn Pro His Gly  Ser Val His 
    1505                 1510                 1515             


Gly Asp  Cys Asp Arg Thr Ser  Gly Gln Cys Val Cys  Arg Leu Gly 
    1520                 1525                 1530             


Ala Ser  Gly Leu Arg Cys Asp  Glu Cys Glu Pro Arg  His Ile Leu 
    1535                 1540                 1545             


Met Glu  Thr Asp Cys Val Ser  Cys Asp Asp Glu Cys  Val Gly Val 
    1550                 1555                 1560             


Leu Leu  Asn Asp Leu Asp Glu  Ile Gly Asp Ala Val  Leu Ser Leu 
    1565                 1570                 1575             


Asn Leu  Thr Gly Ile Ile Pro  Val Pro Tyr Gly Ile  Leu Ser Asn 
    1580                 1585                 1590             


Leu Glu  Asn Thr Thr Lys Tyr  Leu Gln Glu Ser Leu  Leu Lys Glu 
    1595                 1600                 1605             


Asn Met  Gln Lys Asp Leu Gly  Lys Ile Lys Leu Glu  Gly Val Ala 
    1610                 1615                 1620             


Glu Glu  Thr Asp Asn Leu Gln  Lys Lys Leu Thr Arg  Met Leu Ala 
    1625                 1630                 1635             


Ser Thr  Gln Lys Val Asn Arg  Ala Thr Glu Arg Ile  Phe Lys Glu 
    1640                 1645                 1650             


Ser Gln  Asp Leu Ala Ile Ala  Ile Glu Arg Leu Gln  Met Ser Ile 
    1655                 1660                 1665             


Thr Glu  Ile Met Glu Lys Thr  Thr Leu Asn Gln Thr  Leu Asp Glu 
    1670                 1675                 1680             


Asp Phe  Leu Leu Pro Asn Ser  Thr Leu Gln Asn Met  Gln Gln Asn 
    1685                 1690                 1695             


Gly Thr  Ser Leu Leu Glu Ile  Met Gln Ile Arg Asp  Phe Thr Gln 
    1700                 1705                 1710             


Leu His  Gln Asn Ala Thr Leu  Glu Leu Lys Ala Ala  Glu Asp Leu 
    1715                 1720                 1725             


Leu Ser  Gln Ile Gln Glu Asn  Tyr Gln Lys Pro Leu  Glu Glu Leu 
    1730                 1735                 1740             


Glu Val  Leu Lys Glu Ala Ala  Ser His Val Leu Ser  Lys His Asn 
    1745                 1750                 1755             


Asn Glu  Leu Lys Ala Ala Glu  Ala Leu Val Arg Glu  Ala Glu Ala 
    1760                 1765                 1770             


Lys Met  Gln Glu Ser Asn His  Leu Leu Leu Met Val  Asn Ala Asn 
    1775                 1780                 1785             


Leu Arg  Glu Phe Ser Asp Lys  Lys Leu His Val Gln  Glu Glu Gln 
    1790                 1795                 1800             


Asn Leu  Thr Ser Glu Leu Ile  Val Gln Gly Arg Gly  Leu Ile Asp 
    1805                 1810                 1815             


Ala Ala  Ala Ala Gln Thr Asp  Ala Val Gln Asp Ala  Leu Glu His 
    1820                 1825                 1830             


Leu Glu  Asp His Gln Asp Lys  Leu Leu Leu Trp Ser  Ala Lys Ile 
    1835                 1840                 1845             


Arg His  His Ile Asp Asp Leu  Val Met His Met Ser  Gln Arg Asn 
    1850                 1855                 1860             


Ala Val  Asp Leu Val Tyr Arg  Ala Glu Asp His Ala  Ala Glu Phe 
    1865                 1870                 1875             


Gln Arg  Leu Ala Asp Val Leu  Tyr Ser Gly Leu Glu  Asn Ile Arg 
    1880                 1885                 1890             


Asn Val  Ser Leu Asn Ala Thr  Ser Ala Ala Tyr Val  His Tyr Asn 
    1895                 1900                 1905             


Ile Gln  Ser Leu Ile Glu Glu  Ser Glu Glu Leu Ala  Arg Asp Ala 
    1910                 1915                 1920             


His Arg  Thr Val Thr Glu Thr  Ser Leu Leu Ser Glu  Ser Leu Val 
    1925                 1930                 1935             


Ser Asn  Gly Lys Ala Ala Val  Gln Arg Ser Ser Arg  Phe Leu Lys 
    1940                 1945                 1950             


Glu Gly  Asn Asn Leu Ser Arg  Lys Leu Pro Gly Ile  Ala Leu Glu 
    1955                 1960                 1965             


Leu Ser  Glu Leu Arg Asn Lys  Thr Asn Arg Phe Gln  Glu Asn Ala 
    1970                 1975                 1980             


Val Glu  Ile Thr Arg Gln Thr  Asn Glu Ser Leu Leu  Ile Leu Arg 
    1985                 1990                 1995             


Ala Ile  Pro Lys Gly Ile Arg  Asp Lys Gly Ala Lys  Thr Lys Glu 
    2000                 2005                 2010             


Leu Ala  Thr Ser Ala Ser Gln  Ser Ala Val Ser Thr  Leu Arg Asp 
    2015                 2020                 2025             


Val Ala  Gly Leu Ser Gln Glu  Leu Leu Asn Thr Ser  Ala Ser Leu 
    2030                 2035                 2040             


Ser Arg  Val Asn Thr Thr Leu  Arg Glu Thr His Gln  Leu Leu Gln 
    2045                 2050                 2055             


Asp Ser  Thr Met Ala Thr Leu  Leu Ala Gly Arg Lys  Val Lys Asp 
    2060                 2065                 2070             


Val Glu  Ile Gln Ala Asn Leu  Leu Phe Asp Arg Leu  Lys Pro Leu 
    2075                 2080                 2085             


Lys Met  Leu Glu Glu Asn Leu  Ser Arg Asn Leu Ser  Glu Ile Lys 
    2090                 2095                 2100             


Leu Leu  Ile Ser Gln Ala Arg  Lys Gln Ala Ala Ser  Ile Lys Val 
    2105                 2110                 2115             


Ala Val  Ser Ala Asp Arg Asp  Cys Ile Arg Ala Tyr  Gln Pro Gln 
    2120                 2125                 2130             


Ile Ser  Ser Thr Asn Tyr Asn  Thr Leu Thr Leu Asn  Val Lys Thr 
    2135                 2140                 2145             


Gln Glu  Pro Asp Asn Leu Leu  Phe Tyr Leu Gly Ser  Ser Thr Ala 
    2150                 2155                 2160             


Ser Asp  Phe Leu Ala Val Glu  Met Arg Arg Gly Arg  Val Ala Phe 
    2165                 2170                 2175             


Leu Trp  Asp Leu Gly Ser Gly  Ser Thr Arg Leu Glu  Phe Pro Asp 
    2180                 2185                 2190             


Phe Pro  Ile Asp Asp Asn Arg  Trp His Ser Ile His  Val Ala Arg 
    2195                 2200                 2205             


Phe Gly  Asn Ile Gly Ser Leu  Ser Val Lys Glu Met  Ser Ser Asn 
    2210                 2215                 2220             


Gln Lys  Ser Pro Thr Lys Thr  Ser Lys Ser Pro Gly  Thr Ala Asn 
    2225                 2230                 2235             


Val Leu  Asp Val Asn Asn Ser  Thr Leu Met Phe Val  Gly Gly Leu 
    2240                 2245                 2250             


Gly Gly  Gln Ile Lys Lys Ser  Pro Ala Val Lys Val  Thr His Phe 
    2255                 2260                 2265             


Lys Gly  Cys Leu Gly Glu Ala  Phe Leu Asn Gly Lys  Ser Ile Gly 
    2270                 2275                 2280             


Leu Trp  Asn Tyr Ile Glu Arg  Glu Gly Lys Cys Arg  Gly Cys Phe 
    2285                 2290                 2295             


Gly Ser  Ser Gln Asn Glu Asp  Pro Ser Phe His Phe  Asp Gly Ser 
    2300                 2305                 2310             


Gly Tyr  Ser Val Val Glu Lys  Ser Leu Pro Ala Thr  Val Thr Gln 
    2315                 2320                 2325             


Ile Ile  Met Leu Phe Asn Thr  Phe Ser Pro Asn Gly  Leu Leu Leu 
    2330                 2335                 2340             


Tyr Leu  Gly Ser Tyr Gly Thr  Lys Asp Phe Leu Ser  Ile Glu Leu 
    2345                 2350                 2355             


Phe Arg  Gly Arg Val Lys Val  Met Thr Asp Leu Gly  Ser Gly Pro 
    2360                 2365                 2370             


Ile Thr  Leu Leu Thr Asp Arg  Arg Tyr Asn Asn Gly  Thr Trp Tyr 
    2375                 2380                 2385             


Lys Ile  Ala Phe Gln Arg Asn  Arg Lys Gln Gly Val  Leu Ala Val 
    2390                 2395                 2400             


Ile Asp  Ala Tyr Asn Thr Ser  Asn Lys Glu Thr Lys  Gln Gly Glu 
    2405                 2410                 2415             


Thr Pro  Gly Ala Ser Ser Asp  Leu Asn Arg Leu Asp  Lys Asp Pro 
    2420                 2425                 2430             


Ile Tyr  Val Gly Gly Leu Pro  Arg Ser Arg Val Val  Arg Arg Gly 
    2435                 2440                 2445             


Val Thr  Thr Lys Ser Phe Val  Gly Cys Ile Lys Asn  Leu Glu Ile 
    2450                 2455                 2460             


Ser Arg  Ser Thr Phe Asp Leu  Leu Arg Asn Ser Tyr  Gly Val Arg 
    2465                 2470                 2475             


Lys Gly  Cys Leu Leu Glu Pro  Ile Arg Ser Val Ser  Phe Leu Lys 
    2480                 2485                 2490             


Gly Gly  Tyr Ile Glu Leu Pro  Pro Lys Ser Leu Ser  Pro Glu Ser 
    2495                 2500                 2505             


Glu Trp  Leu Val Thr Phe Ala  Thr Thr Asn Ser Ser  Gly Ile Ile 
    2510                 2515                 2520             


Leu Ala  Ala Leu Gly Gly Asp  Val Glu Lys Arg Gly  Asp Arg Glu 
    2525                 2530                 2535             


Glu Ala  His Val Pro Phe Phe  Ser Val Met Leu Ile  Gly Gly Asn 
    2540                 2545                 2550             


Ile Glu  Val His Val Asn Pro  Gly Asp Gly Thr Gly  Leu Arg Lys 
    2555                 2560                 2565             


Ala Leu  Leu His Ala Pro Thr  Gly Thr Cys Ser Asp  Gly Gln Ala 
    2570                 2575                 2580             


His Ser  Ile Ser Leu Val Arg  Asn Arg Arg Ile Ile  Thr Val Gln 
    2585                 2590                 2595             


Leu Asp  Glu Asn Asn Pro Val  Glu Met Lys Leu Gly  Thr Leu Val 
    2600                 2605                 2610             


Glu Ser  Arg Thr Ile Asn Val  Ser Asn Leu Tyr Val  Gly Gly Ile 
    2615                 2620                 2625             


Pro Glu  Gly Glu Gly Thr Ser  Leu Leu Thr Met Arg  Arg Ser Phe 
    2630                 2635                 2640             


His Gly  Cys Ile Lys Asn Leu  Ile Phe Asn Leu Glu  Leu Leu Asp 
    2645                 2650                 2655             


Phe Asn  Ser Ala Val Gly His  Glu Gln Val Asp Leu  Asp Thr Cys 
    2660                 2665                 2670             


Trp Leu  Ser Glu Arg Pro Lys  Leu Ala Pro Asp Ala  Glu Asp Ser 
    2675                 2680                 2685             


Lys Leu  Leu Pro Glu Pro Arg  Ala Phe Pro Glu Gln  Cys Val Val 
    2690                 2695                 2700             


Asp Ala  Ala Leu Glu Tyr Val  Pro Gly Ala His Gln  Phe Gly Leu 
    2705                 2710                 2715             


Thr Gln  Asn Ser His Phe Ile  Leu Pro Phe Asn Gln  Ser Ala Val 
    2720                 2725                 2730             


Arg Lys  Lys Leu Ser Val Glu  Leu Ser Ile Arg Thr  Phe Ala Ser 
    2735                 2740                 2745             


Ser Gly  Leu Ile Tyr Tyr Met  Ala His Gln Asn Gln  Ala Asp Tyr 
    2750                 2755                 2760             


Ala Val  Leu Gln Leu His Gly  Gly Arg Leu His Phe  Met Phe Asp 
    2765                 2770                 2775             


Leu Gly  Lys Gly Arg Thr Lys  Val Ser His Pro Ala  Leu Leu Ser 
    2780                 2785                 2790             


Asp Gly  Lys Trp His Thr Val  Lys Thr Asp Tyr Val  Lys Arg Lys 
    2795                 2800                 2805             


Gly Phe  Ile Thr Val Asp Gly  Arg Glu Ser Pro Met  Val Thr Val 
    2810                 2815                 2820             


Val Gly  Asp Gly Thr Met Leu  Asp Val Glu Gly Leu  Phe Tyr Leu 
    2825                 2830                 2835             


Gly Gly  Leu Pro Ser Gln Tyr  Gln Ala Arg Lys Ile  Gly Asn Ile 
    2840                 2845                 2850             


Thr His  Ser Ile Pro Ala Cys  Ile Gly Asp Val Thr  Val Asn Ser 
    2855                 2860                 2865             


Lys Gln  Leu Asp Lys Asp Ser  Pro Val Ser Ala Phe  Thr Val Asn 
    2870                 2875                 2880             


Arg Cys  Tyr Ala Val Ala Gln  Glu Gly Thr Tyr Phe  Asp Gly Ser 
    2885                 2890                 2895             


Gly Tyr  Ala Ala Leu Val Lys  Glu Gly Tyr Lys Val  Gln Ser Asp 
    2900                 2905                 2910             


Val Asn  Ile Thr Leu Glu Phe  Arg Thr Ser Ser Gln  Asn Gly Val 
    2915                 2920                 2925             


Leu Leu  Gly Ile Ser Thr Ala  Lys Val Asp Ala Ile  Gly Leu Glu 
    2930                 2935                 2940             


Leu Val  Asp Gly Lys Val Leu  Phe His Val Asn Asn  Gly Ala Gly 
    2945                 2950                 2955             


Arg Ile  Thr Ala Ala Tyr Glu  Pro Lys Thr Ala Thr  Val Leu Cys 
    2960                 2965                 2970             


Asp Gly  Lys Trp His Thr Leu  Gln Ala Asn Lys Ser  Lys His Arg 
    2975                 2980                 2985             


Ile Thr  Leu Ile Val Asp Gly  Asn Ala Val Gly Ala  Glu Ser Pro 
    2990                 2995                 3000             


His Thr  Gln Ser Thr Ser Val  Asp Thr Asn Asn Pro  Ile Tyr Val 
    3005                 3010                 3015             


Gly Gly  Tyr Pro Ala Gly Val  Lys Gln Lys Cys Leu  Arg Ser Gln 
    3020                 3025                 3030             


Thr Ser  Phe Arg Gly Cys Leu  Arg Lys Leu Ala Leu  Ile Lys Ser 
    3035                 3040                 3045             


Pro Gln  Val Gln Ser Phe Asp  Phe Ser Arg Ala Phe  Glu Leu His 
    3050                 3055                 3060             


Gly Val  Phe Leu His Ser Cys  Pro Gly Thr Glu Ser  
    3065                 3070                 3075 


<210>  6074
<211>  3122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMA2__Homo_sapiens__NP_000417

<400>  6074

Met Pro Gly Ala Ala Gly Val Leu Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Gly Gly Val Gln Ala Gln Arg Pro Gln Gln Gln Arg Gln Ser Gln 
            20                  25                  30          


Ala His Gln Gln Arg Gly Leu Phe Pro Ala Val Leu Asn Leu Ala Ser 
        35                  40                  45              


Asn Ala Leu Ile Thr Thr Asn Ala Thr Cys Gly Glu Lys Gly Pro Glu 
    50                  55                  60                  


Met Tyr Cys Lys Leu Val Glu His Val Pro Gly Gln Pro Val Arg Asn 
65                  70                  75                  80  


Pro Gln Cys Arg Ile Cys Asn Gln Asn Ser Ser Asn Pro Asn Gln Arg 
                85                  90                  95      


His Pro Ile Thr Asn Ala Ile Asp Gly Lys Asn Thr Trp Trp Gln Ser 
            100                 105                 110         


Pro Ser Ile Lys Asn Gly Ile Glu Tyr His Tyr Val Thr Ile Thr Leu 
        115                 120                 125             


Asp Leu Gln Gln Val Phe Gln Ile Ala Tyr Val Ile Val Lys Ala Ala 
    130                 135                 140                 


Asn Ser Pro Arg Pro Gly Asn Trp Ile Leu Glu Arg Ser Leu Asp Asp 
145                 150                 155                 160 


Val Glu Tyr Lys Pro Trp Gln Tyr His Ala Val Thr Asp Thr Glu Cys 
                165                 170                 175     


Leu Thr Leu Tyr Asn Ile Tyr Pro Arg Thr Gly Pro Pro Ser Tyr Ala 
            180                 185                 190         


Lys Asp Asp Glu Val Ile Cys Thr Ser Phe Tyr Ser Lys Ile His Pro 
        195                 200                 205             


Leu Glu Asn Gly Glu Ile His Ile Ser Leu Ile Asn Gly Arg Pro Ser 
    210                 215                 220                 


Ala Asp Asp Pro Ser Pro Glu Leu Leu Glu Phe Thr Ser Ala Arg Tyr 
225                 230                 235                 240 


Ile Arg Leu Arg Phe Gln Arg Ile Arg Thr Leu Asn Ala Asp Leu Met 
                245                 250                 255     


Met Phe Ala His Lys Asp Pro Arg Glu Ile Asp Pro Ile Val Thr Arg 
            260                 265                 270         


Arg Tyr Tyr Tyr Ser Val Lys Asp Ile Ser Val Gly Gly Met Cys Ile 
        275                 280                 285             


Cys Tyr Gly His Ala Arg Ala Cys Pro Leu Asp Pro Ala Thr Asn Lys 
    290                 295                 300                 


Ser Arg Cys Glu Cys Glu His Asn Thr Cys Gly Asp Ser Cys Asp Gln 
305                 310                 315                 320 


Cys Cys Pro Gly Phe His Gln Lys Pro Trp Arg Ala Gly Thr Phe Leu 
                325                 330                 335     


Thr Lys Thr Glu Cys Glu Ala Cys Asn Cys His Gly Lys Ala Glu Glu 
            340                 345                 350         


Cys Tyr Tyr Asp Glu Asn Val Ala Arg Arg Asn Leu Ser Leu Asn Ile 
        355                 360                 365             


Arg Gly Lys Tyr Ile Gly Gly Gly Val Cys Ile Asn Cys Thr Gln Asn 
    370                 375                 380                 


Thr Ala Gly Ile Asn Cys Glu Thr Cys Thr Asp Gly Phe Phe Arg Pro 
385                 390                 395                 400 


Lys Gly Val Ser Pro Asn Tyr Pro Arg Pro Cys Gln Pro Cys His Cys 
                405                 410                 415     


Asp Pro Ile Gly Ser Leu Asn Glu Val Cys Val Lys Asp Glu Lys His 
            420                 425                 430         


Ala Arg Arg Gly Leu Ala Pro Gly Ser Cys His Cys Lys Thr Gly Phe 
        435                 440                 445             


Gly Gly Val Ser Cys Asp Arg Cys Ala Arg Gly Tyr Thr Gly Tyr Pro 
    450                 455                 460                 


Asp Cys Lys Ala Cys Asn Cys Ser Gly Leu Gly Ser Lys Asn Glu Asp 
465                 470                 475                 480 


Pro Cys Phe Gly Pro Cys Ile Cys Lys Glu Asn Val Glu Gly Gly Asp 
                485                 490                 495     


Cys Ser Arg Cys Lys Ser Gly Phe Phe Asn Leu Gln Glu Asp Asn Trp 
            500                 505                 510         


Lys Gly Cys Asp Glu Cys Phe Cys Ser Gly Val Ser Asn Arg Cys Gln 
        515                 520                 525             


Ser Ser Tyr Trp Thr Tyr Gly Lys Ile Gln Asp Met Ser Gly Trp Tyr 
    530                 535                 540                 


Leu Thr Asp Leu Pro Gly Arg Ile Arg Val Ala Pro Gln Gln Asp Asp 
545                 550                 555                 560 


Leu Asp Ser Pro Gln Gln Ile Ser Ile Ser Asn Ala Glu Ala Arg Gln 
                565                 570                 575     


Ala Leu Pro His Ser Tyr Tyr Trp Ser Ala Pro Ala Pro Tyr Leu Gly 
            580                 585                 590         


Asn Lys Leu Pro Ala Val Gly Gly Gln Leu Thr Phe Thr Ile Ser Tyr 
        595                 600                 605             


Asp Leu Glu Glu Glu Glu Glu Asp Thr Glu Arg Val Leu Gln Leu Met 
    610                 615                 620                 


Ile Ile Leu Glu Gly Asn Asp Leu Ser Ile Ser Thr Ala Gln Asp Glu 
625                 630                 635                 640 


Val Tyr Leu His Pro Ser Glu Glu His Thr Asn Val Leu Leu Leu Lys 
                645                 650                 655     


Glu Glu Ser Phe Thr Ile His Gly Thr His Phe Pro Val Arg Arg Lys 
            660                 665                 670         


Glu Phe Met Thr Val Leu Ala Asn Leu Lys Arg Val Leu Leu Gln Ile 
        675                 680                 685             


Thr Tyr Ser Phe Gly Met Asp Ala Ile Phe Arg Leu Ser Ser Val Asn 
    690                 695                 700                 


Leu Glu Ser Ala Val Ser Tyr Pro Thr Asp Gly Ser Ile Ala Ala Ala 
705                 710                 715                 720 


Val Glu Val Cys Gln Cys Pro Pro Gly Tyr Thr Gly Ser Ser Cys Glu 
                725                 730                 735     


Ser Cys Trp Pro Arg His Arg Arg Val Asn Gly Thr Ile Phe Gly Gly 
            740                 745                 750         


Ile Cys Glu Pro Cys Gln Cys Phe Gly His Ala Glu Ser Cys Asp Asp 
        755                 760                 765             


Val Thr Gly Glu Cys Leu Asn Cys Lys Asp His Thr Gly Gly Pro Tyr 
    770                 775                 780                 


Cys Asp Lys Cys Leu Pro Gly Phe Tyr Gly Glu Pro Thr Lys Gly Thr 
785                 790                 795                 800 


Ser Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Asn Ile Pro Ser Asn 
                805                 810                 815     


Asn Phe Ser Pro Thr Cys His Leu Asp Arg Ser Leu Gly Leu Ile Cys 
            820                 825                 830         


Asp Gly Cys Pro Val Gly Tyr Thr Gly Pro Arg Cys Glu Arg Cys Ala 
        835                 840                 845             


Glu Gly Tyr Phe Gly Gln Pro Ser Val Pro Gly Gly Ser Cys Gln Pro 
    850                 855                 860                 


Cys Gln Cys Asn Asp Asn Leu Asp Phe Ser Ile Pro Gly Ser Cys Asp 
865                 870                 875                 880 


Ser Leu Ser Gly Ser Cys Leu Ile Cys Lys Pro Gly Thr Thr Gly Arg 
                885                 890                 895     


Tyr Cys Glu Leu Cys Ala Asp Gly Tyr Phe Gly Asp Ala Val Asp Ala 
            900                 905                 910         


Lys Asn Cys Gln Pro Cys Arg Cys Asn Ala Gly Gly Ser Phe Ser Glu 
        915                 920                 925             


Val Cys His Ser Gln Thr Gly Gln Cys Glu Cys Arg Ala Asn Val Gln 
    930                 935                 940                 


Gly Gln Arg Cys Asp Lys Cys Lys Ala Gly Thr Phe Gly Leu Gln Ser 
945                 950                 955                 960 


Ala Arg Gly Cys Val Pro Cys Asn Cys Asn Ser Phe Gly Ser Lys Ser 
                965                 970                 975     


Phe Asp Cys Glu Glu Ser Gly Gln Cys Trp Cys Gln Pro Gly Val Thr 
            980                 985                 990         


Gly Lys Lys Cys Asp Arg Cys Ala  His Gly Tyr Phe Asn  Phe Gln Glu 
        995                 1000                 1005             


Gly Gly  Cys Thr Ala Cys Glu  Cys Ser His Leu Gly  Asn Asn Cys 
    1010                 1015                 1020             


Asp Pro  Lys Thr Gly Arg Cys  Ile Cys Pro Pro Asn  Thr Ile Gly 
    1025                 1030                 1035             


Glu Lys  Cys Ser Lys Cys Ala  Pro Asn Thr Trp Gly  His Ser Ile 
    1040                 1045                 1050             


Thr Thr  Gly Cys Lys Ala Cys  Asn Cys Ser Thr Val  Gly Ser Leu 
    1055                 1060                 1065             


Asp Phe  Gln Cys Asn Val Asn  Thr Gly Gln Cys Asn  Cys His Pro 
    1070                 1075                 1080             


Lys Phe  Ser Gly Ala Lys Cys  Thr Glu Cys Ser Arg  Gly His Trp 
    1085                 1090                 1095             


Asn Tyr  Pro Arg Cys Asn Leu  Cys Asp Cys Phe Leu  Pro Gly Thr 
    1100                 1105                 1110             


Asp Ala  Thr Thr Cys Asp Ser  Glu Thr Lys Lys Cys  Ser Cys Ser 
    1115                 1120                 1125             


Asp Gln  Thr Gly Gln Cys Thr  Cys Lys Val Asn Val  Glu Gly Ile 
    1130                 1135                 1140             


His Cys  Asp Arg Cys Arg Pro  Gly Lys Phe Gly Leu  Asp Ala Lys 
    1145                 1150                 1155             


Asn Pro  Leu Gly Cys Ser Ser  Cys Tyr Cys Phe Gly  Thr Thr Thr 
    1160                 1165                 1170             


Gln Cys  Ser Glu Ala Lys Gly  Leu Ile Arg Thr Trp  Val Thr Leu 
    1175                 1180                 1185             


Lys Ala  Glu Gln Thr Ile Leu  Pro Leu Val Asp Glu  Ala Leu Gln 
    1190                 1195                 1200             


His Thr  Thr Thr Lys Gly Ile  Val Phe Gln His Pro  Glu Ile Val 
    1205                 1210                 1215             


Ala His  Met Asp Leu Met Arg  Glu Asp Leu His Leu  Glu Pro Phe 
    1220                 1225                 1230             


Tyr Trp  Lys Leu Pro Glu Gln  Phe Glu Gly Lys Lys  Leu Met Ala 
    1235                 1240                 1245             


Tyr Gly  Gly Lys Leu Lys Tyr  Ala Ile Tyr Phe Glu  Ala Arg Glu 
    1250                 1255                 1260             


Glu Thr  Gly Phe Ser Thr Tyr  Asn Pro Gln Val Ile  Ile Arg Gly 
    1265                 1270                 1275             


Gly Thr  Pro Thr His Ala Arg  Ile Ile Val Arg His  Met Ala Ala 
    1280                 1285                 1290             


Pro Leu  Ile Gly Gln Leu Thr  Arg His Glu Ile Glu  Met Thr Glu 
    1295                 1300                 1305             


Lys Glu  Trp Lys Tyr Tyr Gly  Asp Asp Pro Arg Val  His Arg Thr 
    1310                 1315                 1320             


Val Thr  Arg Glu Asp Phe Leu  Asp Ile Leu Tyr Asp  Ile His Tyr 
    1325                 1330                 1335             


Ile Leu  Ile Lys Ala Thr Tyr  Gly Asn Phe Met Arg  Gln Ser Arg 
    1340                 1345                 1350             


Ile Ser  Glu Ile Ser Met Glu  Val Ala Glu Gln Gly  Arg Gly Thr 
    1355                 1360                 1365             


Thr Met  Thr Pro Pro Ala Asp  Leu Ile Glu Lys Cys  Asp Cys Pro 
    1370                 1375                 1380             


Leu Gly  Tyr Ser Gly Leu Ser  Cys Glu Ala Cys Leu  Pro Gly Phe 
    1385                 1390                 1395             


Tyr Arg  Leu Arg Ser Gln Pro  Gly Gly Arg Thr Pro  Gly Pro Thr 
    1400                 1405                 1410             


Leu Gly  Thr Cys Val Pro Cys  Gln Cys Asn Gly His  Ser Ser Leu 
    1415                 1420                 1425             


Cys Asp  Pro Glu Thr Ser Ile  Cys Gln Asn Cys Gln  His His Thr 
    1430                 1435                 1440             


Ala Gly  Asp Phe Cys Glu Arg  Cys Ala Leu Gly Tyr  Tyr Gly Ile 
    1445                 1450                 1455             


Val Lys  Gly Leu Pro Asn Asp  Cys Gln Gln Cys Ala  Cys Pro Leu 
    1460                 1465                 1470             


Ile Ser  Ser Ser Asn Asn Phe  Ser Pro Ser Cys Val  Ala Glu Gly 
    1475                 1480                 1485             


Leu Asp  Asp Tyr Arg Cys Thr  Ala Cys Pro Arg Gly  Tyr Glu Gly 
    1490                 1495                 1500             


Gln Tyr  Cys Glu Arg Cys Ala  Pro Gly Tyr Thr Gly  Ser Pro Gly 
    1505                 1510                 1515             


Asn Pro  Gly Gly Ser Cys Gln  Glu Cys Glu Cys Asp  Pro Tyr Gly 
    1520                 1525                 1530             


Ser Leu  Pro Val Pro Cys Asp  Pro Val Thr Gly Phe  Cys Thr Cys 
    1535                 1540                 1545             


Arg Pro  Gly Ala Thr Gly Arg  Lys Cys Asp Gly Cys  Lys His Trp 
    1550                 1555                 1560             


His Ala  Arg Glu Gly Trp Glu  Cys Val Phe Cys Gly  Asp Glu Cys 
    1565                 1570                 1575             


Thr Gly  Leu Leu Leu Gly Asp  Leu Ala Arg Leu Glu  Gln Met Val 
    1580                 1585                 1590             


Met Ser  Ile Asn Leu Thr Gly  Pro Leu Pro Ala Pro  Tyr Lys Met 
    1595                 1600                 1605             


Leu Tyr  Gly Leu Glu Asn Met  Thr Gln Glu Leu Lys  His Leu Leu 
    1610                 1615                 1620             


Ser Pro  Gln Arg Ala Pro Glu  Arg Leu Ile Gln Leu  Ala Glu Gly 
    1625                 1630                 1635             


Asn Leu  Asn Thr Leu Val Thr  Glu Met Asn Glu Leu  Leu Thr Arg 
    1640                 1645                 1650             


Ala Thr  Lys Val Thr Ala Asp  Gly Glu Gln Thr Gly  Gln Asp Ala 
    1655                 1660                 1665             


Glu Arg  Thr Asn Thr Arg Ala  Lys Ser Leu Gly Glu  Phe Ile Lys 
    1670                 1675                 1680             


Glu Leu  Ala Arg Asp Ala Glu  Ala Val Asn Glu Lys  Ala Ile Lys 
    1685                 1690                 1695             


Leu Asn  Glu Thr Leu Gly Thr  Arg Asp Glu Ala Phe  Glu Arg Asn 
    1700                 1705                 1710             


Leu Glu  Gly Leu Gln Lys Glu  Ile Asp Gln Met Ile  Lys Glu Leu 
    1715                 1720                 1725             


Arg Arg  Lys Asn Leu Glu Thr  Gln Lys Glu Ile Ala  Glu Asp Glu 
    1730                 1735                 1740             


Leu Val  Ala Ala Glu Ala Leu  Leu Lys Lys Val Lys  Lys Leu Phe 
    1745                 1750                 1755             


Gly Glu  Ser Arg Gly Glu Asn  Glu Glu Met Glu Lys  Asp Leu Arg 
    1760                 1765                 1770             


Glu Lys  Leu Ala Asp Tyr Lys  Asn Lys Val Asp Asp  Ala Trp Asp 
    1775                 1780                 1785             


Leu Leu  Arg Glu Ala Thr Asp  Lys Ile Arg Glu Ala  Asn Arg Leu 
    1790                 1795                 1800             


Phe Ala  Val Asn Gln Lys Asn  Met Thr Ala Leu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Glu Ala  Val Glu Ser Gly Lys  Arg Gln Ile Glu Asn  Thr Leu Lys 
    1820                 1825                 1830             


Glu Gly  Asn Asp Ile Leu Asp  Glu Ala Asn Arg Leu  Ala Asp Glu 
    1835                 1840                 1845             


Ile Asn  Ser Ile Ile Asp Tyr  Val Glu Asp Ile Gln  Thr Lys Leu 
    1850                 1855                 1860             


Pro Pro  Met Ser Glu Glu Leu  Asn Asp Lys Ile Asp  Asp Leu Ser 
    1865                 1870                 1875             


Gln Glu  Ile Lys Asp Arg Lys  Leu Ala Glu Lys Val  Ser Gln Ala 
    1880                 1885                 1890             


Glu Ser  His Ala Ala Gln Leu  Asn Asp Ser Ser Ala  Val Leu Asp 
    1895                 1900                 1905             


Gly Ile  Leu Asp Glu Ala Lys  Asn Ile Ser Phe Asn  Ala Thr Ala 
    1910                 1915                 1920             


Ala Phe  Lys Ala Tyr Ser Asn  Ile Lys Asp Tyr Ile  Asp Glu Ala 
    1925                 1930                 1935             


Glu Lys  Val Ala Lys Glu Ala  Lys Asp Leu Ala His  Glu Ala Thr 
    1940                 1945                 1950             


Lys Leu  Ala Thr Gly Pro Arg  Gly Leu Leu Lys Glu  Asp Ala Lys 
    1955                 1960                 1965             


Gly Cys  Leu Gln Lys Ser Phe  Arg Ile Leu Asn Glu  Ala Lys Lys 
    1970                 1975                 1980             


Leu Ala  Asn Asp Val Lys Glu  Asn Glu Asp His Leu  Asn Gly Leu 
    1985                 1990                 1995             


Lys Thr  Arg Ile Glu Asn Ala  Asp Ala Arg Asn Gly  Asp Leu Leu 
    2000                 2005                 2010             


Arg Thr  Leu Asn Asp Thr Leu  Gly Lys Leu Ser Ala  Ile Pro Asn 
    2015                 2020                 2025             


Asp Thr  Ala Ala Lys Leu Gln  Ala Val Lys Asp Lys  Ala Arg Gln 
    2030                 2035                 2040             


Ala Asn  Asp Thr Ala Lys Asp  Val Leu Ala Gln Ile  Thr Glu Leu 
    2045                 2050                 2055             


His Gln  Asn Leu Asp Gly Leu  Lys Lys Asn Tyr Asn  Lys Leu Ala 
    2060                 2065                 2070             


Asp Ser  Val Ala Lys Thr Asn  Ala Val Val Lys Asp  Pro Ser Lys 
    2075                 2080                 2085             


Asn Lys  Ile Ile Ala Asp Ala  Asp Ala Thr Val Lys  Asn Leu Glu 
    2090                 2095                 2100             


Gln Glu  Ala Asp Arg Leu Ile  Asp Lys Leu Lys Pro  Ile Lys Glu 
    2105                 2110                 2115             


Leu Glu  Asp Asn Leu Lys Lys  Asn Ile Ser Glu Ile  Lys Glu Leu 
    2120                 2125                 2130             


Ile Asn  Gln Ala Arg Lys Gln  Ala Asn Ser Ile Lys  Val Ser Val 
    2135                 2140                 2145             


Ser Ser  Gly Gly Asp Cys Ile  Arg Thr Tyr Lys Pro  Glu Ile Lys 
    2150                 2155                 2160             


Lys Gly  Ser Tyr Asn Asn Ile  Val Val Asn Val Lys  Thr Ala Val 
    2165                 2170                 2175             


Ala Asp  Asn Leu Leu Phe Tyr  Leu Gly Ser Ala Lys  Phe Ile Asp 
    2180                 2185                 2190             


Phe Leu  Ala Ile Glu Met Arg  Lys Gly Lys Val Ser  Phe Leu Trp 
    2195                 2200                 2205             


Asp Val  Gly Ser Gly Val Gly  Arg Val Glu Tyr Pro  Asp Leu Thr 
    2210                 2215                 2220             


Ile Asp  Asp Ser Tyr Trp Tyr  Arg Ile Val Ala Ser  Arg Thr Gly 
    2225                 2230                 2235             


Arg Asn  Gly Thr Ile Ser Val  Arg Ala Leu Asp Gly  Pro Lys Ala 
    2240                 2245                 2250             


Ser Ile  Val Pro Ser Thr His  His Ser Thr Ser Pro  Pro Gly Tyr 
    2255                 2260                 2265             


Thr Ile  Leu Asp Val Asp Ala  Asn Ala Met Leu Phe  Val Gly Gly 
    2270                 2275                 2280             


Leu Thr  Gly Lys Leu Lys Lys  Ala Asp Ala Val Arg  Val Ile Thr 
    2285                 2290                 2295             


Phe Thr  Gly Cys Met Gly Glu  Thr Tyr Phe Asp Asn  Lys Pro Ile 
    2300                 2305                 2310             


Gly Leu  Trp Asn Phe Arg Glu  Lys Glu Gly Asp Cys  Lys Gly Cys 
    2315                 2320                 2325             


Thr Val  Ser Pro Gln Val Glu  Asp Ser Glu Gly Thr  Ile Gln Phe 
    2330                 2335                 2340             


Asp Gly  Glu Gly Tyr Ala Leu  Val Ser Arg Pro Ile  Arg Trp Tyr 
    2345                 2350                 2355             


Pro Asn  Ile Ser Thr Val Met  Phe Lys Phe Arg Thr  Phe Ser Ser 
    2360                 2365                 2370             


Ser Ala  Leu Leu Met Tyr Leu  Ala Thr Arg Asp Leu  Arg Asp Phe 
    2375                 2380                 2385             


Met Ser  Val Glu Leu Thr Asp  Gly His Ile Lys Val  Ser Tyr Asp 
    2390                 2395                 2400             


Leu Gly  Ser Gly Met Ala Ser  Val Val Ser Asn Gln  Asn His Asn 
    2405                 2410                 2415             


Asp Gly  Lys Trp Lys Ser Phe  Thr Leu Ser Arg Ile  Gln Lys Gln 
    2420                 2425                 2430             


Ala Asn  Ile Ser Ile Val Asp  Ile Asp Thr Asn Gln  Glu Glu Asn 
    2435                 2440                 2445             


Ile Ala  Thr Ser Ser Ser Gly  Asn Asn Phe Gly Leu  Asp Leu Lys 
    2450                 2455                 2460             


Ala Asp  Asp Lys Ile Tyr Phe  Gly Gly Leu Pro Thr  Leu Arg Asn 
    2465                 2470                 2475             


Leu Ser  Met Lys Ala Arg Pro  Glu Val Asn Leu Lys  Lys Tyr Ser 
    2480                 2485                 2490             


Gly Cys  Leu Lys Asp Ile Glu  Ile Ser Arg Thr Pro  Tyr Asn Ile 
    2495                 2500                 2505             


Leu Ser  Ser Pro Asp Tyr Val  Gly Val Thr Lys Gly  Cys Ser Leu 
    2510                 2515                 2520             


Glu Asn  Val Tyr Thr Val Ser  Phe Pro Lys Pro Gly  Phe Val Glu 
    2525                 2530                 2535             


Leu Ser  Pro Val Pro Ile Asp  Val Gly Thr Glu Ile  Asn Leu Ser 
    2540                 2545                 2550             


Phe Ser  Thr Lys Asn Glu Ser  Gly Ile Ile Leu Leu  Gly Ser Gly 
    2555                 2560                 2565             


Gly Thr  Pro Ala Pro Pro Arg  Arg Lys Arg Arg Gln  Thr Gly Gln 
    2570                 2575                 2580             


Ala Tyr  Tyr Val Ile Leu Leu  Asn Arg Gly Arg Leu  Glu Val His 
    2585                 2590                 2595             


Leu Ser  Thr Gly Ala Arg Thr  Met Arg Lys Ile Val  Ile Arg Pro 
    2600                 2605                 2610             


Glu Pro  Asn Leu Phe His Asp  Gly Arg Glu His Ser  Val His Val 
    2615                 2620                 2625             


Glu Arg  Thr Arg Gly Ile Phe  Thr Val Gln Val Asp  Glu Asn Arg 
    2630                 2635                 2640             


Arg Tyr  Met Gln Asn Leu Thr  Val Glu Gln Pro Ile  Glu Val Lys 
    2645                 2650                 2655             


Lys Leu  Phe Val Gly Gly Ala  Pro Pro Glu Phe Gln  Pro Ser Pro 
    2660                 2665                 2670             


Leu Arg  Asn Ile Pro Pro Phe  Glu Gly Cys Ile Trp  Asn Leu Val 
    2675                 2680                 2685             


Ile Asn  Ser Val Pro Met Asp  Phe Ala Arg Pro Val  Ser Phe Lys 
    2690                 2695                 2700             


Asn Ala  Asp Ile Gly Arg Cys  Ala His Gln Lys Leu  Arg Glu Asp 
    2705                 2710                 2715             


Glu Asp  Gly Ala Ala Pro Ala  Glu Ile Val Ile Gln  Pro Glu Pro 
    2720                 2725                 2730             


Val Pro  Thr Pro Ala Phe Pro  Thr Pro Thr Pro Val  Leu Thr His 
    2735                 2740                 2745             


Gly Pro  Cys Ala Ala Glu Ser  Glu Pro Ala Leu Leu  Ile Gly Ser 
    2750                 2755                 2760             


Lys Gln  Phe Gly Leu Ser Arg  Asn Ser His Ile Ala  Ile Ala Phe 
    2765                 2770                 2775             


Asp Asp  Thr Lys Val Lys Asn  Arg Leu Thr Ile Glu  Leu Glu Val 
    2780                 2785                 2790             


Arg Thr  Glu Ala Glu Ser Gly  Leu Leu Phe Tyr Met  Ala Arg Ile 
    2795                 2800                 2805             


Asn His  Ala Asp Phe Ala Thr  Val Gln Leu Arg Asn  Gly Leu Pro 
    2810                 2815                 2820             


Tyr Phe  Ser Tyr Asp Leu Gly  Ser Gly Asp Thr His  Thr Met Ile 
    2825                 2830                 2835             


Pro Thr  Lys Ile Asn Asp Gly  Gln Trp His Lys Ile  Lys Ile Met 
    2840                 2845                 2850             


Arg Ser  Lys Gln Glu Gly Ile  Leu Tyr Val Asp Gly  Ala Ser Asn 
    2855                 2860                 2865             


Arg Thr  Ile Ser Pro Lys Lys  Ala Asp Ile Leu Asp  Val Val Gly 
    2870                 2875                 2880             


Met Leu  Tyr Val Gly Gly Leu  Pro Ile Asn Tyr Thr  Thr Arg Arg 
    2885                 2890                 2895             


Ile Gly  Pro Val Thr Tyr Ser  Ile Asp Gly Cys Val  Arg Asn Leu 
    2900                 2905                 2910             


His Met  Ala Glu Ala Pro Ala  Asp Leu Glu Gln Pro  Thr Ser Ser 
    2915                 2920                 2925             


Phe His  Val Gly Thr Cys Phe  Ala Asn Ala Gln Arg  Gly Thr Tyr 
    2930                 2935                 2940             


Phe Asp  Gly Thr Gly Phe Ala  Lys Ala Val Gly Gly  Phe Lys Val 
    2945                 2950                 2955             


Gly Leu  Asp Leu Leu Val Glu  Phe Glu Phe Arg Thr  Thr Thr Thr 
    2960                 2965                 2970             


Thr Gly  Val Leu Leu Gly Ile  Ser Ser Gln Lys Met  Asp Gly Met 
    2975                 2980                 2985             


Gly Ile  Glu Met Ile Asp Glu  Lys Leu Met Phe His  Val Asp Asn 
    2990                 2995                 3000             


Gly Ala  Gly Arg Phe Thr Ala  Val Tyr Asp Ala Gly  Val Pro Gly 
    3005                 3010                 3015             


His Leu  Cys Asp Gly Gln Trp  His Lys Val Thr Ala  Asn Lys Ile 
    3020                 3025                 3030             


Lys His  Arg Ile Glu Leu Thr  Val Asp Gly Asn Gln  Val Glu Ala 
    3035                 3040                 3045             


Gln Ser  Pro Asn Pro Ala Ser  Thr Ser Ala Asp Thr  Asn Asp Pro 
    3050                 3055                 3060             


Val Phe  Val Gly Gly Phe Pro  Asp Asp Leu Lys Gln  Phe Gly Leu 
    3065                 3070                 3075             


Thr Thr  Ser Ile Pro Phe Arg  Gly Cys Ile Arg Ser  Leu Lys Leu 
    3080                 3085                 3090             


Thr Lys  Gly Thr Gly Lys Pro  Leu Glu Val Asn Phe  Ala Lys Ala 
    3095                 3100                 3105             


Leu Glu  Leu Arg Gly Val Gln  Pro Val Ser Cys Pro  Ala Asn 
    3110                 3115                 3120         


<210>  6075
<211>  1724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMA3__Homo_sapiens__NP_000218

<400>  6075

Met Pro Pro Ala Val Arg Arg Ser Ala Cys Ser Met Gly Trp Leu Trp 
1               5                   10                  15      


Ile Phe Gly Ala Ala Leu Gly Gln Cys Leu Gly Tyr Ser Ser Gln Gln 
            20                  25                  30          


Gln Arg Val Pro Phe Leu Gln Pro Pro Gly Gln Ser Gln Leu Gln Ala 
        35                  40                  45              


Ser Tyr Val Glu Phe Arg Pro Ser Gln Gly Cys Ser Pro Gly Tyr Tyr 
    50                  55                  60                  


Arg Asp His Lys Gly Leu Tyr Thr Gly Arg Cys Val Pro Cys Asn Cys 
65                  70                  75                  80  


Asn Gly His Ser Asn Gln Cys Gln Asp Gly Ser Gly Ile Cys Val Asn 
                85                  90                  95      


Cys Gln His Asn Thr Ala Gly Glu His Cys Glu Arg Cys Gln Glu Gly 
            100                 105                 110         


Tyr Tyr Gly Asn Ala Val His Gly Ser Cys Arg Ala Cys Pro Cys Pro 
        115                 120                 125             


His Thr Asn Ser Phe Ala Thr Gly Cys Val Val Asn Gly Gly Asp Val 
    130                 135                 140                 


Arg Cys Ser Cys Lys Ala Gly Tyr Thr Gly Thr Gln Cys Glu Arg Cys 
145                 150                 155                 160 


Ala Pro Gly Tyr Phe Gly Asn Pro Gln Lys Phe Gly Gly Ser Cys Gln 
                165                 170                 175     


Pro Cys Ser Cys Asn Ser Asn Gly Gln Leu Gly Ser Cys His Pro Leu 
            180                 185                 190         


Thr Gly Asp Cys Ile Asn Gln Glu Pro Lys Asp Ser Ser Pro Ala Glu 
        195                 200                 205             


Glu Cys Asp Asp Cys Asp Ser Cys Val Met Thr Leu Leu Asn Asp Leu 
    210                 215                 220                 


Ala Thr Met Gly Glu Gln Leu Arg Leu Val Lys Ser Gln Leu Gln Gly 
225                 230                 235                 240 


Leu Ser Ala Ser Ala Gly Leu Leu Glu Gln Met Arg His Met Glu Thr 
                245                 250                 255     


Gln Ala Lys Asp Leu Arg Asn Gln Leu Leu Asn Tyr Arg Ser Ala Ile 
            260                 265                 270         


Ser Asn His Gly Ser Lys Ile Glu Gly Leu Glu Arg Glu Leu Thr Asp 
        275                 280                 285             


Leu Asn Gln Glu Phe Glu Thr Leu Gln Glu Lys Ala Gln Val Asn Ser 
    290                 295                 300                 


Arg Lys Ala Gln Thr Leu Asn Asn Asn Val Asn Arg Ala Thr Gln Ser 
305                 310                 315                 320 


Ala Lys Glu Leu Asp Val Lys Ile Lys Asn Val Ile Arg Asn Val His 
                325                 330                 335     


Ile Leu Leu Lys Gln Ile Ser Gly Thr Asp Gly Glu Gly Asn Asn Val 
            340                 345                 350         


Pro Ser Gly Asp Phe Ser Arg Glu Trp Ala Glu Ala Gln Arg Met Met 
        355                 360                 365             


Arg Glu Leu Arg Asn Arg Asn Phe Gly Lys His Leu Arg Glu Ala Glu 
    370                 375                 380                 


Ala Asp Lys Arg Glu Ser Gln Leu Leu Leu Asn Arg Ile Arg Thr Trp 
385                 390                 395                 400 


Gln Lys Thr His Gln Gly Glu Asn Asn Gly Leu Ala Asn Ser Ile Arg 
                405                 410                 415     


Asp Ser Leu Asn Glu Tyr Glu Ala Lys Leu Ser Asp Leu Arg Ala Arg 
            420                 425                 430         


Leu Gln Glu Ala Ala Ala Gln Ala Lys Gln Ala Asn Gly Leu Asn Gln 
        435                 440                 445             


Glu Asn Glu Arg Ala Leu Gly Ala Ile Gln Arg Gln Val Lys Glu Ile 
    450                 455                 460                 


Asn Ser Leu Gln Ser Asp Phe Thr Lys Tyr Leu Thr Thr Ala Asp Ser 
465                 470                 475                 480 


Ser Leu Leu Gln Thr Asn Ile Ala Leu Gln Leu Met Glu Lys Ser Gln 
                485                 490                 495     


Lys Glu Tyr Glu Lys Leu Ala Ala Ser Leu Asn Glu Ala Arg Gln Glu 
            500                 505                 510         


Leu Ser Asp Lys Val Arg Glu Leu Ser Arg Ser Ala Gly Lys Thr Ser 
        515                 520                 525             


Leu Val Glu Glu Ala Glu Lys His Ala Arg Ser Leu Gln Glu Leu Ala 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ile Lys Arg Asn Ala Ser Gly Asp Glu Leu Val 
545                 550                 555                 560 


Arg Cys Ala Val Asp Ala Ala Thr Ala Tyr Glu Asn Ile Leu Asn Ala 
                565                 570                 575     


Ile Lys Ala Ala Glu Asp Ala Ala Asn Arg Ala Ala Ser Ala Ser Glu 
            580                 585                 590         


Ser Ala Leu Gln Thr Val Ile Lys Glu Asp Leu Pro Arg Lys Ala Lys 
        595                 600                 605             


Thr Leu Ser Ser Asn Ser Asp Lys Leu Leu Asn Glu Ala Lys Met Thr 
    610                 615                 620                 


Gln Lys Lys Leu Lys Gln Glu Val Ser Pro Ala Leu Asn Asn Leu Gln 
625                 630                 635                 640 


Gln Thr Leu Asn Ile Val Thr Val Gln Lys Glu Val Ile Asp Thr Asn 
                645                 650                 655     


Leu Thr Thr Leu Arg Asp Gly Leu His Gly Ile Gln Arg Gly Asp Ile 
            660                 665                 670         


Asp Ala Met Ile Ser Ser Ala Lys Ser Met Val Arg Lys Ala Asn Asp 
        675                 680                 685             


Ile Thr Asp Glu Val Leu Asp Gly Leu Asn Pro Ile Gln Thr Asp Val 
    690                 695                 700                 


Glu Arg Ile Lys Asp Thr Tyr Gly Arg Thr Gln Asn Glu Asp Phe Lys 
705                 710                 715                 720 


Lys Ala Leu Thr Asp Ala Asp Asn Ser Val Asn Lys Leu Thr Asn Lys 
                725                 730                 735     


Leu Pro Asp Leu Trp Arg Lys Ile Glu Ser Ile Asn Gln Gln Leu Leu 
            740                 745                 750         


Pro Leu Gly Asn Ile Ser Asp Asn Met Asp Arg Ile Arg Glu Leu Ile 
        755                 760                 765             


Gln Gln Ala Arg Asp Ala Ala Ser Lys Val Ala Val Pro Met Arg Phe 
    770                 775                 780                 


Asn Gly Lys Ser Gly Val Glu Val Arg Leu Pro Asn Asp Leu Glu Asp 
785                 790                 795                 800 


Leu Lys Gly Tyr Thr Ser Leu Ser Leu Phe Leu Gln Arg Pro Asn Ser 
                805                 810                 815     


Arg Glu Asn Gly Gly Thr Glu Asn Met Phe Val Met Tyr Leu Gly Asn 
            820                 825                 830         


Lys Asp Ala Ser Arg Asp Tyr Ile Gly Met Ala Val Val Asp Gly Gln 
        835                 840                 845             


Leu Thr Cys Val Tyr Asn Leu Gly Asp Arg Glu Ala Glu Leu Gln Val 
    850                 855                 860                 


Asp Gln Ile Leu Thr Lys Ser Glu Thr Lys Glu Ala Val Met Asp Arg 
865                 870                 875                 880 


Val Lys Phe Gln Arg Ile Tyr Gln Phe Ala Arg Leu Asn Tyr Thr Lys 
                885                 890                 895     


Gly Ala Thr Ser Ser Lys Pro Glu Thr Pro Gly Val Tyr Asp Met Asp 
            900                 905                 910         


Gly Arg Asn Ser Asn Thr Leu Leu Asn Leu Asp Pro Glu Asn Val Val 
        915                 920                 925             


Phe Tyr Val Gly Gly Tyr Pro Pro Asp Phe Lys Leu Pro Ser Arg Leu 
    930                 935                 940                 


Ser Phe Pro Pro Tyr Lys Gly Cys Ile Glu Leu Asp Asp Leu Asn Glu 
945                 950                 955                 960 


Asn Val Leu Ser Leu Tyr Asn Phe Lys Lys Thr Phe Asn Leu Asn Thr 
                965                 970                 975     


Thr Glu Val Glu Pro Cys Arg Arg Arg Lys Glu Glu Ser Asp Lys Asn 
            980                 985                 990         


Tyr Phe Glu Gly Thr Gly Tyr Ala  Arg Val Pro Thr Gln  Pro His Ala 
        995                 1000                 1005             


Pro Ile  Pro Thr Phe Gly Gln  Thr Ile Gln Thr Thr  Val Asp Arg 
    1010                 1015                 1020             


Gly Leu  Leu Phe Phe Ala Glu  Asn Gly Asp Arg Phe  Ile Ser Leu 
    1025                 1030                 1035             


Asn Ile  Glu Asp Gly Lys Leu  Met Val Arg Tyr Lys  Leu Asn Ser 
    1040                 1045                 1050             


Glu Leu  Pro Lys Glu Arg Gly  Val Gly Asp Ala Ile  Asn Asn Gly 
    1055                 1060                 1065             


Arg Asp  His Ser Ile Gln Ile  Lys Ile Gly Lys Leu  Gln Lys Arg 
    1070                 1075                 1080             


Met Trp  Ile Asn Val Asp Val  Gln Asn Thr Ile Ile  Asp Gly Glu 
    1085                 1090                 1095             


Val Phe  Asp Phe Ser Thr Tyr  Tyr Leu Gly Gly Ile  Pro Ile Ala 
    1100                 1105                 1110             


Ile Arg  Glu Arg Phe Asn Ile  Ser Thr Pro Ala Phe  Arg Gly Cys 
    1115                 1120                 1125             


Met Lys  Asn Leu Lys Lys Thr  Ser Gly Val Val Arg  Leu Asn Asp 
    1130                 1135                 1140             


Thr Val  Gly Val Thr Lys Lys  Cys Ser Glu Asp Trp  Lys Leu Val 
    1145                 1150                 1155             


Arg Ser  Ala Ser Phe Ser Arg  Gly Gly Gln Leu Ser  Phe Thr Asp 
    1160                 1165                 1170             


Leu Gly  Leu Pro Pro Thr Asp  His Leu Gln Ala Ser  Phe Gly Phe 
    1175                 1180                 1185             


Gln Thr  Phe Gln Pro Ser Gly  Ile Leu Leu Asp His  Gln Thr Trp 
    1190                 1195                 1200             


Thr Arg  Asn Leu Gln Val Thr  Leu Glu Asp Gly Tyr  Ile Glu Leu 
    1205                 1210                 1215             


Ser Thr  Ser Asp Ser Gly Gly  Pro Ile Phe Lys Ser  Pro Gln Thr 
    1220                 1225                 1230             


Tyr Met  Asp Gly Leu Leu His  Tyr Val Ser Val Ile  Ser Asp Asn 
    1235                 1240                 1245             


Ser Gly  Leu Arg Leu Leu Ile  Asp Asp Gln Leu Leu  Arg Asn Ser 
    1250                 1255                 1260             


Lys Arg  Leu Lys His Ile Ser  Ser Ser Arg Gln Ser  Leu Arg Leu 
    1265                 1270                 1275             


Gly Gly  Ser Asn Phe Glu Gly  Cys Ile Ser Asn Val  Phe Val Gln 
    1280                 1285                 1290             


Arg Leu  Ser Leu Ser Pro Glu  Val Leu Asp Leu Thr  Ser Asn Ser 
    1295                 1300                 1305             


Leu Lys  Arg Asp Val Ser Leu  Gly Gly Cys Ser Leu  Asn Lys Pro 
    1310                 1315                 1320             


Pro Phe  Leu Met Leu Leu Lys  Gly Ser Thr Arg Phe  Asn Lys Thr 
    1325                 1330                 1335             


Lys Thr  Phe Arg Ile Asn Gln  Leu Leu Gln Asp Thr  Pro Val Ala 
    1340                 1345                 1350             


Ser Pro  Arg Ser Val Lys Val  Trp Gln Asp Ala Cys  Ser Pro Leu 
    1355                 1360                 1365             


Pro Lys  Thr Gln Ala Asn His  Gly Ala Leu Gln Phe  Gly Asp Ile 
    1370                 1375                 1380             


Pro Thr  Ser His Leu Leu Phe  Lys Leu Pro Gln Glu  Leu Leu Lys 
    1385                 1390                 1395             


Pro Arg  Ser Gln Phe Ala Val  Asp Met Gln Thr Thr  Ser Ser Arg 
    1400                 1405                 1410             


Gly Leu  Val Phe His Thr Gly  Thr Lys Asn Ser Phe  Met Ala Leu 
    1415                 1420                 1425             


Tyr Leu  Ser Lys Gly Arg Leu  Val Phe Ala Leu Gly  Thr Asp Gly 
    1430                 1435                 1440             


Lys Lys  Leu Arg Ile Lys Ser  Lys Glu Lys Cys Asn  Asp Gly Lys 
    1445                 1450                 1455             


Trp His  Thr Val Val Phe Gly  His Asp Gly Glu Lys  Gly Arg Leu 
    1460                 1465                 1470             


Val Val  Asp Gly Leu Arg Ala  Arg Glu Gly Ser Leu  Pro Gly Asn 
    1475                 1480                 1485             


Ser Thr  Ile Ser Ile Arg Ala  Pro Val Tyr Leu Gly  Ser Pro Pro 
    1490                 1495                 1500             


Ser Gly  Lys Pro Lys Ser Leu  Pro Thr Asn Ser Phe  Val Gly Cys 
    1505                 1510                 1515             


Leu Lys  Asn Phe Gln Leu Asp  Ser Lys Pro Leu Tyr  Thr Pro Ser 
    1520                 1525                 1530             


Ser Ser  Phe Gly Val Ser Ser  Cys Leu Gly Gly Pro  Leu Glu Lys 
    1535                 1540                 1545             


Gly Ile  Tyr Phe Ser Glu Glu  Gly Gly His Val Val  Leu Ala His 
    1550                 1555                 1560             


Ser Val  Leu Leu Gly Pro Glu  Phe Lys Leu Val Phe  Ser Ile Arg 
    1565                 1570                 1575             


Pro Arg  Ser Leu Thr Gly Ile  Leu Ile His Ile Gly  Ser Gln Pro 
    1580                 1585                 1590             


Gly Lys  His Leu Cys Val Tyr  Leu Glu Ala Gly Lys  Val Thr Ala 
    1595                 1600                 1605             


Ser Met  Asp Ser Gly Ala Gly  Gly Thr Ser Thr Ser  Val Thr Pro 
    1610                 1615                 1620             


Lys Gln  Ser Leu Cys Asp Gly  Gln Trp His Ser Val  Ala Val Thr 
    1625                 1630                 1635             


Ile Lys  Gln His Ile Leu His  Leu Glu Leu Asp Thr  Asp Ser Ser 
    1640                 1645                 1650             


Tyr Thr  Ala Gly Gln Ile Pro  Phe Pro Pro Ala Ser  Thr Gln Glu 
    1655                 1660                 1665             


Pro Leu  His Leu Gly Gly Ala  Pro Ala Asn Leu Thr  Thr Leu Arg 
    1670                 1675                 1680             


Ile Pro  Val Trp Lys Ser Phe  Phe Gly Cys Leu Arg  Asn Ile His 
    1685                 1690                 1695             


Val Asn  His Ile Pro Val Pro  Val Thr Glu Ala Leu  Glu Val Gln 
    1700                 1705                 1710             


Gly Pro  Val Ser Leu Asn Gly  Cys Pro Asp Gln 
    1715                 1720                 


<210>  6076
<211>  1823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMA4__Homo_sapiens__NP_001098676

<400>  6076

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser 
            260                 265                 270         


Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Asp Leu Arg Leu Ala Ala 
        275                 280                 285             


Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly 
    290                 295                 300                 


Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys 
                325                 330                 335     


Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp 
            340                 345                 350         


Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln 
        355                 360                 365             


Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu 
    370                 375                 380                 


Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn 
385                 390                 395                 400 


Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile 
                405                 410                 415     


Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser 
            420                 425                 430         


Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp 
        435                 440                 445             


Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His 
    450                 455                 460                 


Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp 
465                 470                 475                 480 


Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu 
                485                 490                 495     


Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg 
            500                 505                 510         


Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu 
        515                 520                 525             


Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro 
    530                 535                 540                 


Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly 
545                 550                 555                 560 


Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu 
                565                 570                 575     


Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp 
            580                 585                 590         


His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu 
        595                 600                 605             


His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser 
    610                 615                 620                 


Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr 
625                 630                 635                 640 


Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser 
                645                 650                 655     


Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu 
            660                 665                 670         


Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp 
        675                 680                 685             


Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg 
    690                 695                 700                 


Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln 
705                 710                 715                 720 


Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu 
                725                 730                 735     


Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr 
            740                 745                 750         


Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His 
        755                 760                 765             


Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala 
    770                 775                 780                 


Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg 
785                 790                 795                 800 


Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln 
                805                 810                 815     


Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile 
            820                 825                 830         


Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser 
        835                 840                 845             


Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr 
    850                 855                 860                 


Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln 
865                 870                 875                 880 


Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly 
                885                 890                 895     


Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr 
            900                 905                 910         


Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro 
        915                 920                 925             


Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys 
    930                 935                 940                 


Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe 
945                 950                 955                 960 


Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp 
                965                 970                 975     


Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys 
            980                 985                 990         


Leu Pro Thr Ser Leu Asn Leu Pro  Gly Phe Val Gly Cys  Leu Glu Leu 
        995                 1000                 1005             


Ala Thr  Leu Asn Asn Asp Val  Ile Ser Leu Tyr Asn  Phe Lys His 
    1010                 1015                 1020             


Ile Tyr  Asn Met Asp Pro Ser  Thr Ser Val Pro Cys  Ala Arg Asp 
    1025                 1030                 1035             


Lys Leu  Ala Phe Thr Gln Ser  Arg Ala Ala Ser Tyr  Phe Phe Asp 
    1040                 1045                 1050             


Gly Ser  Gly Tyr Ala Val Val  Arg Asp Ile Thr Arg  Arg Gly Lys 
    1055                 1060                 1065             


Phe Gly  Gln Val Thr Arg Phe  Asp Ile Glu Val Arg  Thr Pro Ala 
    1070                 1075                 1080             


Asp Asn  Gly Leu Ile Leu Leu  Met Val Asn Gly Ser  Met Phe Phe 
    1085                 1090                 1095             


Arg Leu  Glu Met Arg Asn Gly  Tyr Leu His Val Phe  Tyr Asp Phe 
    1100                 1105                 1110             


Gly Phe  Ser Gly Gly Pro Val  His Leu Glu Asp Thr  Leu Lys Lys 
    1115                 1120                 1125             


Ala Gln  Ile Asn Asp Ala Lys  Tyr His Glu Ile Ser  Ile Ile Tyr 
    1130                 1135                 1140             


His Asn  Asp Lys Lys Met Ile  Leu Val Val Asp Arg  Arg His Val 
    1145                 1150                 1155             


Lys Ser  Met Asp Asn Glu Lys  Met Lys Ile Pro Phe  Thr Asp Ile 
    1160                 1165                 1170             


Tyr Ile  Gly Gly Ala Pro Pro  Glu Ile Leu Gln Ser  Arg Ala Leu 
    1175                 1180                 1185             


Arg Ala  His Leu Pro Leu Asp  Ile Asn Phe Arg Gly  Cys Met Lys 
    1190                 1195                 1200             


Gly Phe  Gln Phe Gln Lys Lys  Asp Phe Asn Leu Leu  Glu Gln Thr 
    1205                 1210                 1215             


Glu Thr  Leu Gly Val Gly Tyr  Gly Cys Pro Glu Asp  Ser Leu Ile 
    1220                 1225                 1230             


Ser Arg  Arg Ala Tyr Phe Asn  Gly Gln Ser Phe Ile  Ala Ser Ile 
    1235                 1240                 1245             


Gln Lys  Ile Ser Phe Phe Asp  Gly Phe Glu Gly Gly  Phe Asn Phe 
    1250                 1255                 1260             


Arg Thr  Leu Gln Pro Asn Gly  Leu Leu Phe Tyr Tyr  Ala Ser Gly 
    1265                 1270                 1275             


Ser Asp  Val Phe Ser Ile Ser  Leu Asp Asn Gly Thr  Val Ile Met 
    1280                 1285                 1290             


Asp Val  Lys Gly Ile Lys Val  Gln Ser Val Asp Lys  Gln Tyr Asn 
    1295                 1300                 1305             


Asp Gly  Leu Ser His Phe Val  Ile Ser Ser Val Ser  Pro Thr Arg 
    1310                 1315                 1320             


Tyr Glu  Leu Ile Val Asp Lys  Ser Arg Val Gly Ser  Lys Asn Pro 
    1325                 1330                 1335             


Thr Lys  Gly Lys Ile Glu Gln  Thr Gln Ala Ser Glu  Lys Lys Phe 
    1340                 1345                 1350             


Tyr Phe  Gly Gly Ser Pro Ile  Ser Ala Gln Tyr Ala  Asn Phe Thr 
    1355                 1360                 1365             


Gly Cys  Ile Ser Asn Ala Tyr  Phe Thr Arg Val Asp  Arg Asp Val 
    1370                 1375                 1380             


Glu Val  Glu Asp Phe Gln Arg  Tyr Thr Glu Lys Val  His Thr Ser 
    1385                 1390                 1395             


Leu Tyr  Glu Cys Pro Ile Glu  Ser Ser Pro Leu Phe  Leu Leu His 
    1400                 1405                 1410             


Lys Lys  Gly Lys Asn Leu Ser  Lys Pro Lys Ala Ser  Gln Asn Lys 
    1415                 1420                 1425             


Lys Gly  Gly Lys Ser Lys Asp  Ala Pro Ser Trp Asp  Pro Val Ala 
    1430                 1435                 1440             


Leu Lys  Leu Pro Glu Arg Asn  Thr Pro Arg Asn Ser  His Cys His 
    1445                 1450                 1455             


Leu Ser  Asn Ser Pro Arg Ala  Ile Glu His Ala Tyr  Gln Tyr Gly 
    1460                 1465                 1470             


Gly Thr  Ala Asn Ser Arg Gln  Glu Phe Glu His Leu  Lys Gly Asp 
    1475                 1480                 1485             


Phe Gly  Ala Lys Ser Gln Phe  Ser Ile Arg Leu Arg  Thr Arg Ser 
    1490                 1495                 1500             


Ser His  Gly Met Ile Phe Tyr  Val Ser Asp Gln Glu  Glu Asn Asp 
    1505                 1510                 1515             


Phe Met  Thr Leu Phe Leu Ala  His Gly Arg Leu Val  Tyr Met Phe 
    1520                 1525                 1530             


Asn Val  Gly His Lys Lys Leu  Lys Ile Arg Ser Gln  Glu Lys Tyr 
    1535                 1540                 1545             


Asn Asp  Gly Leu Trp His Asp  Val Ile Phe Ile Arg  Glu Arg Ser 
    1550                 1555                 1560             


Ser Gly  Arg Leu Val Ile Asp  Gly Leu Arg Val Leu  Glu Glu Ser 
    1565                 1570                 1575             


Leu Pro  Pro Thr Glu Ala Thr  Trp Lys Ile Lys Gly  Pro Ile Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Val Ala Pro Gly  Lys Ala Val Lys Asn  Val Gln Ile 
    1595                 1600                 1605             


Asn Ser  Ile Tyr Ser Phe Ser  Gly Cys Leu Ser Asn  Leu Gln Leu 
    1610                 1615                 1620             


Asn Gly  Ala Ser Ile Thr Ser  Ala Ser Gln Thr Phe  Ser Val Thr 
    1625                 1630                 1635             


Pro Cys  Phe Glu Gly Pro Met  Glu Thr Gly Thr Tyr  Phe Ser Thr 
    1640                 1645                 1650             


Glu Gly  Gly Tyr Val Val Leu  Asp Glu Ser Phe Asn  Ile Gly Leu 
    1655                 1660                 1665             


Lys Phe  Glu Ile Ala Phe Glu  Val Arg Pro Arg Ser  Ser Ser Gly 
    1670                 1675                 1680             


Thr Leu  Val His Gly His Ser  Val Asn Gly Glu Tyr  Leu Asn Val 
    1685                 1690                 1695             


His Met  Lys Asn Gly Gln Val  Ile Val Lys Val Asn  Asn Gly Ile 
    1700                 1705                 1710             


Arg Asp  Phe Ser Thr Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp 
    1715                 1720                 1725             


Gly Arg  Trp His Arg Ile Thr  Val Ile Arg Asp Ser  Asn Val Val 
    1730                 1735                 1740             


Gln Leu  Asp Val Asp Ser Glu  Val Asn His Val Val  Gly Pro Leu 
    1745                 1750                 1755             


Asn Pro  Lys Pro Ile Asp His  Arg Glu Pro Val Phe  Val Gly Gly 
    1760                 1765                 1770             


Val Pro  Glu Ser Leu Leu Thr  Pro Arg Leu Ala Pro  Ser Lys Pro 
    1775                 1780                 1785             


Phe Thr  Gly Cys Ile Arg His  Phe Val Ile Asp Gly  His Pro Val 
    1790                 1795                 1800             


Ser Phe  Ser Lys Ala Ala Leu  Val Ser Gly Ala Val  Ser Ile Asn 
    1805                 1810                 1815             


Ser Cys  Pro Ala Ala 
    1820             


<210>  6077
<211>  3695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMA5__Homo_sapiens__NP_005551

<400>  6077

Met Ala Lys Arg Leu Cys Ala Gly Ser Ala Leu Cys Val Arg Gly Pro 
1               5                   10                  15      


Arg Gly Pro Ala Pro Leu Leu Leu Val Gly Leu Ala Leu Leu Gly Ala 
            20                  25                  30          


Ala Arg Ala Arg Glu Glu Ala Gly Gly Gly Phe Ser Leu His Pro Pro 
        35                  40                  45              


Tyr Phe Asn Leu Ala Glu Gly Ala Arg Ile Ala Ala Ser Ala Thr Cys 
    50                  55                  60                  


Gly Glu Glu Ala Pro Ala Arg Gly Ser Pro Arg Pro Thr Glu Asp Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Val Ala Gly Gly Asp Pro Asn Gln 
                85                  90                  95      


Thr Ile Arg Gly Gln Tyr Cys Asp Ile Cys Thr Ala Ala Asn Ser Asn 
            100                 105                 110         


Lys Ala His Pro Ala Ser Asn Ala Ile Asp Gly Thr Glu Arg Trp Trp 
        115                 120                 125             


Gln Ser Pro Pro Leu Ser Arg Gly Leu Glu Tyr Asn Glu Val Asn Val 
    130                 135                 140                 


Thr Leu Asp Leu Gly Gln Val Phe His Val Ala Tyr Val Leu Ile Lys 
145                 150                 155                 160 


Phe Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Met 
                165                 170                 175     


Asp Phe Gly Arg Thr Tyr Gln Pro Trp Gln Phe Phe Ala Ser Ser Lys 
            180                 185                 190         


Arg Asp Cys Leu Glu Arg Phe Gly Pro Gln Thr Leu Glu Arg Ile Thr 
        195                 200                 205             


Arg Asp Asp Ala Ala Ile Cys Thr Thr Glu Tyr Ser Arg Ile Val Pro 
    210                 215                 220                 


Leu Glu Asn Gly Glu Ile Val Val Ser Leu Val Asn Gly Arg Pro Gly 
225                 230                 235                 240 


Ala Met Asn Phe Ser Tyr Ser Pro Leu Leu Arg Glu Phe Thr Lys Ala 
                245                 250                 255     


Thr Asn Val Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His 
            260                 265                 270         


Leu Met Gly Lys Ala Leu Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr 
        275                 280                 285             


Tyr Ser Ile Lys Asp Ile Ser Ile Gly Gly Arg Cys Val Cys His Gly 
    290                 295                 300                 


His Ala Asp Ala Cys Asp Ala Lys Asp Pro Thr Asp Pro Phe Arg Leu 
305                 310                 315                 320 


Gln Cys Thr Cys Gln His Asn Thr Cys Gly Gly Thr Cys Asp Arg Cys 
                325                 330                 335     


Cys Pro Gly Phe Asn Gln Gln Pro Trp Lys Pro Ala Thr Ala Asn Ser 
            340                 345                 350         


Ala Asn Glu Cys Gln Ser Cys Asn Cys Tyr Gly His Ala Thr Asp Cys 
        355                 360                 365             


Tyr Tyr Asp Pro Glu Val Asp Arg Arg Arg Ala Ser Gln Ser Leu Asp 
    370                 375                 380                 


Gly Thr Tyr Gln Gly Gly Gly Val Cys Ile Asp Cys Gln His His Thr 
385                 390                 395                 400 


Thr Gly Val Asn Cys Glu Arg Cys Leu Pro Gly Phe Tyr Arg Ser Pro 
                405                 410                 415     


Asn His Pro Leu Asp Ser Pro His Val Cys Arg Arg Cys Asn Cys Glu 
            420                 425                 430         


Ser Asp Phe Thr Asp Gly Thr Cys Glu Asp Leu Thr Gly Arg Cys Tyr 
        435                 440                 445             


Cys Arg Pro Asn Phe Ser Gly Glu Arg Cys Asp Val Cys Ala Glu Gly 
    450                 455                 460                 


Phe Thr Gly Phe Pro Ser Cys Tyr Pro Thr Pro Ser Ser Ser Asn Asp 
465                 470                 475                 480 


Thr Arg Glu Gln Val Leu Pro Ala Gly Gln Ile Val Asn Cys Asp Cys 
                485                 490                 495     


Ser Ala Ala Gly Thr Gln Gly Asn Ala Cys Arg Lys Asp Pro Arg Val 
            500                 505                 510         


Gly Arg Cys Leu Cys Lys Pro Asn Phe Gln Gly Thr His Cys Glu Leu 
        515                 520                 525             


Cys Ala Pro Gly Phe Tyr Gly Pro Gly Cys Gln Pro Cys Gln Cys Ser 
    530                 535                 540                 


Ser Pro Gly Val Ala Asp Asp Arg Cys Asp Pro Asp Thr Gly Gln Cys 
545                 550                 555                 560 


Arg Cys Arg Val Gly Phe Glu Gly Ala Thr Cys Asp Arg Cys Ala Pro 
                565                 570                 575     


Gly Tyr Phe His Phe Pro Leu Cys Gln Leu Cys Gly Cys Ser Pro Ala 
            580                 585                 590         


Gly Thr Leu Pro Glu Gly Cys Asp Glu Ala Gly Arg Cys Leu Cys Gln 
        595                 600                 605             


Pro Glu Phe Ala Gly Pro His Cys Asp Arg Cys Arg Pro Gly Tyr His 
    610                 615                 620                 


Gly Phe Pro Asn Cys Gln Ala Cys Thr Cys Asp Pro Arg Gly Ala Leu 
625                 630                 635                 640 


Asp Gln Leu Cys Gly Ala Gly Gly Leu Cys Arg Cys Arg Pro Gly Tyr 
                645                 650                 655     


Thr Gly Thr Ala Cys Gln Glu Cys Ser Pro Gly Phe His Gly Phe Pro 
            660                 665                 670         


Ser Cys Val Pro Cys His Cys Ser Ala Glu Gly Ser Leu His Ala Ala 
        675                 680                 685             


Cys Asp Pro Arg Ser Gly Gln Cys Ser Cys Arg Pro Arg Val Thr Gly 
    690                 695                 700                 


Leu Arg Cys Asp Thr Cys Val Pro Gly Ala Tyr Asn Phe Pro Tyr Cys 
705                 710                 715                 720 


Glu Ala Gly Ser Cys His Pro Ala Gly Leu Ala Pro Val Asp Pro Ala 
                725                 730                 735     


Leu Pro Glu Ala Gln Val Pro Cys Met Cys Arg Ala His Val Glu Gly 
            740                 745                 750         


Pro Ser Cys Asp Arg Cys Lys Pro Gly Phe Trp Gly Leu Ser Pro Ser 
        755                 760                 765             


Asn Pro Glu Gly Cys Thr Arg Cys Ser Cys Asp Leu Arg Gly Thr Leu 
    770                 775                 780                 


Gly Gly Val Ala Glu Cys Gln Pro Gly Thr Gly Gln Cys Phe Cys Lys 
785                 790                 795                 800 


Pro His Val Cys Gly Gln Ala Cys Ala Ser Cys Lys Asp Gly Phe Phe 
                805                 810                 815     


Gly Leu Asp Gln Ala Asp Tyr Phe Gly Cys Arg Ser Cys Arg Cys Asp 
            820                 825                 830         


Ile Gly Gly Ala Leu Gly Gln Ser Cys Glu Pro Arg Thr Gly Val Cys 
        835                 840                 845             


Arg Cys Arg Pro Asn Thr Gln Gly Pro Thr Cys Ser Glu Pro Ala Arg 
    850                 855                 860                 


Asp His Tyr Leu Pro Asp Leu His His Leu Arg Leu Glu Leu Glu Glu 
865                 870                 875                 880 


Ala Ala Thr Pro Glu Gly His Ala Val Arg Phe Gly Phe Asn Pro Leu 
                885                 890                 895     


Glu Phe Glu Asn Phe Ser Trp Arg Gly Tyr Ala Gln Met Ala Pro Val 
            900                 905                 910         


Gln Pro Arg Ile Val Ala Arg Leu Asn Leu Thr Ser Pro Asp Leu Phe 
        915                 920                 925             


Trp Leu Val Phe Arg Tyr Val Asn Arg Gly Ala Met Ser Val Ser Gly 
    930                 935                 940                 


Arg Val Ser Val Arg Glu Glu Gly Arg Ser Ala Thr Cys Ala Asn Cys 
945                 950                 955                 960 


Thr Ala Gln Ser Gln Pro Val Ala Phe Pro Pro Ser Thr Glu Pro Ala 
                965                 970                 975     


Phe Ile Thr Val Pro Gln Arg Gly Phe Gly Glu Pro Phe Val Leu Asn 
            980                 985                 990         


Pro Gly Thr Trp Ala Leu Arg Val  Glu Ala Glu Gly Val  Leu Leu Asp 
        995                 1000                 1005             


Tyr Val  Val Leu Leu Pro Ser  Ala Tyr Tyr Glu Ala  Ala Leu Leu 
    1010                 1015                 1020             


Gln Leu  Arg Val Thr Glu Ala  Cys Thr Tyr Arg Pro  Ser Ala Gln 
    1025                 1030                 1035             


Gln Ser  Gly Asp Asn Cys Leu  Leu Tyr Thr His Leu  Pro Leu Asp 
    1040                 1045                 1050             


Gly Phe  Pro Ser Ala Ala Gly  Leu Glu Ala Leu Cys  Arg Gln Asp 
    1055                 1060                 1065             


Asn Ser  Leu Pro Arg Pro Cys  Pro Thr Glu Gln Leu  Ser Pro Ser 
    1070                 1075                 1080             


His Pro  Pro Leu Ile Thr Cys  Thr Gly Ser Asp Val  Asp Val Gln 
    1085                 1090                 1095             


Leu Gln  Val Ala Val Pro Gln  Pro Gly Arg Tyr Ala  Leu Val Val 
    1100                 1105                 1110             


Glu Tyr  Ala Asn Glu Asp Ala  Arg Gln Glu Val Gly  Val Ala Val 
    1115                 1120                 1125             


His Thr  Pro Gln Arg Ala Pro  Gln Gln Gly Leu Leu  Ser Leu His 
    1130                 1135                 1140             


Pro Cys  Leu Tyr Ser Thr Leu  Cys Arg Gly Thr Ala  Arg Asp Thr 
    1145                 1150                 1155             


Gln Asp  His Leu Ala Val Phe  His Leu Asp Ser Glu  Ala Ser Val 
    1160                 1165                 1170             


Arg Leu  Thr Ala Glu Gln Ala  Arg Phe Phe Leu His  Gly Val Thr 
    1175                 1180                 1185             


Leu Val  Pro Ile Glu Glu Phe  Ser Pro Glu Phe Val  Glu Pro Arg 
    1190                 1195                 1200             


Val Ser  Cys Ile Ser Ser His  Gly Ala Phe Gly Pro  Asn Ser Ala 
    1205                 1210                 1215             


Ala Cys  Leu Pro Ser Arg Phe  Pro Lys Pro Pro Gln  Pro Ile Ile 
    1220                 1225                 1230             


Leu Arg  Asp Cys Gln Val Ile  Pro Leu Pro Pro Gly  Leu Pro Leu 
    1235                 1240                 1245             


Thr His  Ala Gln Asp Leu Thr  Pro Ala Met Ser Pro  Ala Gly Pro 
    1250                 1255                 1260             


Arg Pro  Arg Pro Pro Thr Ala  Val Asp Pro Asp Ala  Glu Pro Thr 
    1265                 1270                 1275             


Leu Leu  Arg Glu Pro Gln Ala  Thr Val Val Phe Thr  Thr His Val 
    1280                 1285                 1290             


Pro Thr  Leu Gly Arg Tyr Ala  Phe Leu Leu His Gly  Tyr Gln Pro 
    1295                 1300                 1305             


Ala His  Pro Thr Phe Pro Val  Glu Val Leu Ile Asn  Ala Gly Arg 
    1310                 1315                 1320             


Val Trp  Gln Gly His Ala Asn  Ala Ser Phe Cys Pro  His Gly Tyr 
    1325                 1330                 1335             


Gly Cys  Arg Thr Leu Val Val  Cys Glu Gly Gln Ala  Leu Leu Asp 
    1340                 1345                 1350             


Val Thr  His Ser Glu Leu Thr  Val Thr Val Arg Val  Pro Lys Gly 
    1355                 1360                 1365             


Arg Trp  Leu Trp Leu Asp Tyr  Val Leu Val Val Pro  Glu Asn Val 
    1370                 1375                 1380             


Tyr Ser  Phe Gly Tyr Leu Arg  Glu Glu Pro Leu Asp  Lys Ser Tyr 
    1385                 1390                 1395             


Asp Phe  Ile Ser His Cys Ala  Ala Gln Gly Tyr His  Ile Ser Pro 
    1400                 1405                 1410             


Ser Ser  Ser Ser Leu Phe Cys  Arg Asn Ala Ala Ala  Ser Leu Ser 
    1415                 1420                 1425             


Leu Phe  Tyr Asn Asn Gly Ala  Arg Pro Cys Gly Cys  His Glu Val 
    1430                 1435                 1440             


Gly Ala  Thr Gly Pro Thr Cys  Glu Pro Phe Gly Gly  Gln Cys Pro 
    1445                 1450                 1455             


Cys His  Ala His Val Ile Gly  Arg Asp Cys Ser Arg  Cys Ala Thr 
    1460                 1465                 1470             


Gly Tyr  Trp Gly Phe Pro Asn  Cys Arg Pro Cys Asp  Cys Gly Ala 
    1475                 1480                 1485             


Arg Leu  Cys Asp Glu Leu Thr  Gly Gln Cys Ile Cys  Pro Pro Arg 
    1490                 1495                 1500             


Thr Ile  Pro Pro Asp Cys Leu  Leu Cys Gln Pro Gln  Thr Phe Gly 
    1505                 1510                 1515             


Cys His  Pro Leu Val Gly Cys  Glu Glu Cys Asn Cys  Ser Gly Pro 
    1520                 1525                 1530             


Gly Ile  Gln Glu Leu Thr Asp  Pro Thr Cys Asp Thr  Asp Ser Gly 
    1535                 1540                 1545             


Gln Cys  Lys Cys Arg Pro Asn  Val Thr Gly Arg Arg  Cys Asp Thr 
    1550                 1555                 1560             


Cys Ser  Pro Gly Phe His Gly  Tyr Pro Arg Cys Arg  Pro Cys Asp 
    1565                 1570                 1575             


Cys His  Glu Ala Gly Thr Ala  Pro Gly Val Cys Asp  Pro Leu Thr 
    1580                 1585                 1590             


Gly Gln  Cys Tyr Cys Lys Glu  Asn Val Gln Gly Pro  Lys Cys Asp 
    1595                 1600                 1605             


Gln Cys  Ser Leu Gly Thr Phe  Ser Leu Asp Ala Ala  Asn Pro Lys 
    1610                 1615                 1620             


Gly Cys  Thr Arg Cys Phe Cys  Phe Gly Ala Thr Glu  Arg Cys Arg 
    1625                 1630                 1635             


Ser Ser  Ser Tyr Thr Arg Gln  Glu Phe Val Asp Met  Glu Gly Trp 
    1640                 1645                 1650             


Val Leu  Leu Ser Thr Asp Arg  Gln Val Val Pro His  Glu Arg Gln 
    1655                 1660                 1665             


Pro Gly  Thr Glu Met Leu Arg  Ala Asp Leu Arg His  Val Pro Glu 
    1670                 1675                 1680             


Ala Val  Pro Glu Ala Phe Pro  Glu Leu Tyr Trp Gln  Ala Pro Pro 
    1685                 1690                 1695             


Ser Tyr  Leu Gly Asp Arg Val  Ser Ser Tyr Gly Gly  Thr Leu Arg 
    1700                 1705                 1710             


Tyr Glu  Leu His Ser Glu Thr  Gln Arg Gly Asp Val  Phe Val Pro 
    1715                 1720                 1725             


Met Glu  Ser Arg Pro Asp Val  Val Leu Gln Gly Asn  Gln Met Ser 
    1730                 1735                 1740             


Ile Thr  Phe Leu Glu Pro Ala  Tyr Pro Thr Pro Gly  His Val His 
    1745                 1750                 1755             


Arg Gly  Gln Leu Gln Leu Val  Glu Gly Asn Phe Arg  His Thr Glu 
    1760                 1765                 1770             


Thr Arg  Asn Thr Val Ser Arg  Glu Glu Leu Met Met  Val Leu Ala 
    1775                 1780                 1785             


Ser Leu  Glu Gln Leu Gln Ile  Arg Ala Leu Phe Ser  Gln Ile Ser 
    1790                 1795                 1800             


Ser Ala  Val Phe Leu Arg Arg  Val Ala Leu Glu Val  Ala Ser Pro 
    1805                 1810                 1815             


Ala Gly  Gln Gly Ala Leu Ala  Ser Asn Val Glu Leu  Cys Leu Cys 
    1820                 1825                 1830             


Pro Ala  Ser Tyr Arg Gly Asp  Ser Cys Gln Glu Cys  Ala Pro Gly 
    1835                 1840                 1845             


Phe Tyr  Arg Asp Val Lys Gly  Leu Phe Leu Gly Arg  Cys Val Pro 
    1850                 1855                 1860             


Cys Gln  Cys His Gly His Ser  Asp Arg Cys Leu Pro  Gly Ser Gly 
    1865                 1870                 1875             


Val Cys  Val Asp Cys Gln His  Asn Thr Glu Gly Ala  His Cys Glu 
    1880                 1885                 1890             


Arg Cys  Gln Ala Gly Phe Val  Ser Ser Arg Asp Asp  Pro Ser Ala 
    1895                 1900                 1905             


Pro Cys  Val Ser Cys Pro Cys  Pro Leu Ser Val Pro  Ser Asn Asn 
    1910                 1915                 1920             


Phe Ala  Glu Gly Cys Val Leu  Arg Gly Gly Arg Thr  Gln Cys Leu 
    1925                 1930                 1935             


Cys Lys  Pro Gly Tyr Ala Gly  Ala Ser Cys Glu Arg  Cys Ala Pro 
    1940                 1945                 1950             


Gly Phe  Phe Gly Asn Pro Leu  Val Leu Gly Ser Ser  Cys Gln Pro 
    1955                 1960                 1965             


Cys Asp  Cys Ser Gly Asn Gly  Asp Pro Asn Leu Leu  Phe Ser Asp 
    1970                 1975                 1980             


Cys Asp  Pro Leu Thr Gly Ala  Cys Arg Gly Cys Leu  Arg His Thr 
    1985                 1990                 1995             


Thr Gly  Pro Arg Cys Glu Ile  Cys Ala Pro Gly Phe  Tyr Gly Asn 
    2000                 2005                 2010             


Ala Leu  Leu Pro Gly Asn Cys  Thr Arg Cys Asp Cys  Thr Pro Cys 
    2015                 2020                 2025             


Gly Thr  Glu Ala Cys Asp Pro  His Ser Gly His Cys  Leu Cys Lys 
    2030                 2035                 2040             


Ala Gly  Val Thr Gly Arg Arg  Cys Asp Arg Cys Gln  Glu Gly His 
    2045                 2050                 2055             


Phe Gly  Phe Asp Gly Cys Gly  Gly Cys Arg Pro Cys  Ala Cys Gly 
    2060                 2065                 2070             


Pro Ala  Ala Glu Gly Ser Glu  Cys His Pro Gln Ser  Gly Gln Cys 
    2075                 2080                 2085             


His Cys  Arg Pro Gly Thr Met  Gly Pro Gln Cys Arg  Glu Cys Ala 
    2090                 2095                 2100             


Pro Gly  Tyr Trp Gly Leu Pro  Glu Gln Gly Cys Arg  Arg Cys Gln 
    2105                 2110                 2115             


Cys Pro  Gly Gly Arg Cys Asp  Pro His Thr Gly Arg  Cys Asn Cys 
    2120                 2125                 2130             


Pro Pro  Gly Leu Ser Gly Glu  Arg Cys Asp Thr Cys  Ser Gln Gln 
    2135                 2140                 2145             


His Gln  Val Pro Val Pro Gly  Gly Pro Val Gly His  Ser Ile His 
    2150                 2155                 2160             


Cys Glu  Val Cys Asp His Cys  Val Val Leu Leu Leu  Asp Asp Leu 
    2165                 2170                 2175             


Glu Arg  Ala Gly Ala Leu Leu  Pro Ala Ile His Glu  Gln Leu Arg 
    2180                 2185                 2190             


Gly Ile  Asn Ala Ser Ser Met  Ala Trp Ala Arg Leu  His Arg Leu 
    2195                 2200                 2205             


Asn Ala  Ser Ile Ala Asp Leu  Gln Ser Gln Leu Arg  Ser Pro Leu 
    2210                 2215                 2220             


Gly Pro  Arg His Glu Thr Ala  Gln Gln Leu Glu Val  Leu Glu Gln 
    2225                 2230                 2235             


Gln Ser  Thr Ser Leu Gly Gln  Asp Ala Arg Arg Leu  Gly Gly Gln 
    2240                 2245                 2250             


Ala Val  Gly Thr Arg Asp Gln  Ala Ser Gln Leu Leu  Ala Gly Thr 
    2255                 2260                 2265             


Glu Ala  Thr Leu Gly His Ala  Lys Thr Leu Leu Ala  Ala Ile Arg 
    2270                 2275                 2280             


Ala Val  Asp Arg Thr Leu Ser  Glu Leu Met Ser Gln  Thr Gly His 
    2285                 2290                 2295             


Leu Gly  Leu Ala Asn Ala Ser  Ala Pro Ser Gly Glu  Gln Leu Leu 
    2300                 2305                 2310             


Arg Thr  Leu Ala Glu Val Glu  Arg Leu Leu Trp Glu  Met Arg Ala 
    2315                 2320                 2325             


Arg Asp  Leu Gly Ala Pro Gln  Ala Ala Ala Glu Ala  Glu Leu Ala 
    2330                 2335                 2340             


Ala Ala  Gln Arg Leu Leu Ala  Arg Val Gln Glu Gln  Leu Ser Ser 
    2345                 2350                 2355             


Leu Trp  Glu Glu Asn Gln Ala  Leu Ala Thr Gln Thr  Arg Asp Arg 
    2360                 2365                 2370             


Leu Ala  Gln His Glu Ala Gly  Leu Met Asp Leu Arg  Glu Ala Leu 
    2375                 2380                 2385             


Asn Arg  Ala Val Asp Ala Thr  Arg Glu Ala Gln Glu  Leu Asn Ser 
    2390                 2395                 2400             


Arg Asn  Gln Glu Arg Leu Glu  Glu Ala Leu Gln Arg  Lys Gln Glu 
    2405                 2410                 2415             


Leu Ser  Arg Asp Asn Ala Thr  Leu Gln Ala Thr Leu  His Ala Ala 
    2420                 2425                 2430             


Arg Asp  Thr Leu Ala Ser Val  Phe Arg Leu Leu His  Ser Leu Asp 
    2435                 2440                 2445             


Gln Ala  Lys Glu Glu Leu Glu  Arg Leu Ala Ala Ser  Leu Asp Gly 
    2450                 2455                 2460             


Ala Arg  Thr Pro Leu Leu Gln  Arg Met Gln Thr Phe  Ser Pro Ala 
    2465                 2470                 2475             


Gly Ser  Lys Leu Arg Leu Val  Glu Ala Ala Glu Ala  His Ala Gln 
    2480                 2485                 2490             


Gln Leu  Gly Gln Leu Ala Leu  Asn Leu Ser Ser Ile  Ile Leu Asp 
    2495                 2500                 2505             


Val Asn  Gln Asp Arg Leu Thr  Gln Arg Ala Ile Glu  Ala Ser Asn 
    2510                 2515                 2520             


Ala Tyr  Ser Arg Ile Leu Gln  Ala Val Gln Ala Ala  Glu Asp Ala 
    2525                 2530                 2535             


Ala Gly  Gln Ala Leu Gln Gln  Ala Asp His Thr Trp  Ala Thr Val 
    2540                 2545                 2550             


Val Arg  Gln Gly Leu Val Asp  Arg Ala Gln Gln Leu  Leu Ala Asn 
    2555                 2560                 2565             


Ser Thr  Ala Leu Glu Glu Ala  Met Leu Gln Glu Gln  Gln Arg Leu 
    2570                 2575                 2580             


Gly Leu  Val Trp Ala Ala Leu  Gln Gly Ala Arg Thr  Gln Leu Arg 
    2585                 2590                 2595             


Asp Val  Arg Ala Lys Lys Asp  Gln Leu Glu Ala His  Ile Gln Ala 
    2600                 2605                 2610             


Ala Gln  Ala Met Leu Ala Met  Asp Thr Asp Glu Thr  Ser Lys Lys 
    2615                 2620                 2625             


Ile Ala  His Ala Lys Ala Val  Ala Ala Glu Ala Gln  Asp Thr Ala 
    2630                 2635                 2640             


Thr Arg  Val Gln Ser Gln Leu  Gln Ala Met Gln Glu  Asn Val Glu 
    2645                 2650                 2655             


Arg Trp  Gln Gly Gln Tyr Glu  Gly Leu Arg Gly Gln  Asp Leu Gly 
    2660                 2665                 2670             


Gln Ala  Val Leu Asp Ala Gly  His Ser Val Ser Thr  Leu Glu Lys 
    2675                 2680                 2685             


Thr Leu  Pro Gln Leu Leu Ala  Lys Leu Ser Ile Leu  Glu Asn Arg 
    2690                 2695                 2700             


Gly Val  His Asn Ala Ser Leu  Ala Leu Ser Ala Ser  Ile Gly Arg 
    2705                 2710                 2715             


Val Arg  Glu Leu Ile Ala Gln  Ala Arg Gly Ala Ala  Ser Lys Val 
    2720                 2725                 2730             


Lys Val  Pro Met Lys Phe Asn  Gly Arg Ser Gly Val  Gln Leu Arg 
    2735                 2740                 2745             


Thr Pro  Arg Asp Leu Ala Asp  Leu Ala Ala Tyr Thr  Ala Leu Lys 
    2750                 2755                 2760             


Phe Tyr  Leu Gln Gly Pro Glu  Pro Glu Pro Gly Gln  Gly Thr Glu 
    2765                 2770                 2775             


Asp Arg  Phe Val Met Tyr Met  Gly Ser Arg Gln Ala  Thr Gly Asp 
    2780                 2785                 2790             


Tyr Met  Gly Val Ser Leu Arg  Asp Lys Lys Val His  Trp Val Tyr 
    2795                 2800                 2805             


Gln Leu  Gly Glu Ala Gly Pro  Ala Val Leu Ser Ile  Asp Glu Asp 
    2810                 2815                 2820             


Ile Gly  Glu Gln Phe Ala Ala  Val Ser Leu Asp Arg  Thr Leu Gln 
    2825                 2830                 2835             


Phe Gly  His Met Ser Val Thr  Val Glu Arg Gln Met  Ile Gln Glu 
    2840                 2845                 2850             


Thr Lys  Gly Asp Thr Val Ala  Pro Gly Ala Glu Gly  Leu Leu Asn 
    2855                 2860                 2865             


Leu Arg  Pro Asp Asp Phe Val  Phe Tyr Val Gly Gly  Tyr Pro Ser 
    2870                 2875                 2880             


Thr Phe  Thr Pro Pro Pro Leu  Leu Arg Phe Pro Gly  Tyr Arg Gly 
    2885                 2890                 2895             


Cys Ile  Glu Met Asp Thr Leu  Asn Glu Glu Val Val  Ser Leu Tyr 
    2900                 2905                 2910             


Asn Phe  Glu Arg Thr Phe Gln  Leu Asp Thr Ala Val  Asp Arg Pro 
    2915                 2920                 2925             


Cys Ala  Arg Ser Lys Ser Thr  Gly Asp Pro Trp Leu  Thr Asp Gly 
    2930                 2935                 2940             


Ser Tyr  Leu Asp Gly Thr Gly  Phe Ala Arg Ile Ser  Phe Asp Ser 
    2945                 2950                 2955             


Gln Ile  Ser Thr Thr Lys Arg  Phe Glu Gln Glu Leu  Arg Leu Val 
    2960                 2965                 2970             


Ser Tyr  Ser Gly Val Leu Phe  Phe Leu Lys Gln Gln  Ser Gln Phe 
    2975                 2980                 2985             


Leu Cys  Leu Ala Val Gln Glu  Gly Ser Leu Val Leu  Leu Tyr Asp 
    2990                 2995                 3000             


Phe Gly  Ala Gly Leu Lys Lys  Ala Val Pro Leu Gln  Pro Pro Pro 
    3005                 3010                 3015             


Pro Leu  Thr Ser Ala Ser Lys  Ala Ile Gln Val Phe  Leu Leu Gly 
    3020                 3025                 3030             


Gly Ser  Arg Lys Arg Val Leu  Val Arg Val Glu Arg  Ala Thr Val 
    3035                 3040                 3045             


Tyr Ser  Val Glu Gln Asp Asn  Asp Leu Glu Leu Ala  Asp Ala Tyr 
    3050                 3055                 3060             


Tyr Leu  Gly Gly Val Pro Pro  Asp Gln Leu Pro Pro  Ser Leu Arg 
    3065                 3070                 3075             


Arg Leu  Phe Pro Thr Gly Gly  Ser Val Arg Gly Cys  Val Lys Gly 
    3080                 3085                 3090             


Ile Lys  Ala Leu Gly Lys Tyr  Val Asp Leu Lys Arg  Leu Asn Thr 
    3095                 3100                 3105             


Thr Gly  Val Ser Ala Gly Cys  Thr Ala Asp Leu Leu  Val Gly Arg 
    3110                 3115                 3120             


Ala Met  Thr Phe His Gly His  Gly Phe Leu Arg Leu  Ala Leu Ser 
    3125                 3130                 3135             


Asn Val  Ala Pro Leu Thr Gly  Asn Val Tyr Ser Gly  Phe Gly Phe 
    3140                 3145                 3150             


His Ser  Ala Gln Asp Ser Ala  Leu Leu Tyr Tyr Arg  Ala Ser Pro 
    3155                 3160                 3165             


Asp Gly  Leu Cys Gln Val Ser  Leu Gln Gln Gly Arg  Val Ser Leu 
    3170                 3175                 3180             


Gln Leu  Leu Arg Thr Glu Val  Lys Thr Gln Ala Gly  Phe Ala Asp 
    3185                 3190                 3195             


Gly Ala  Pro His Tyr Val Ala  Phe Tyr Ser Asn Ala  Thr Gly Val 
    3200                 3205                 3210             


Trp Leu  Tyr Val Asp Asp Gln  Leu Gln Gln Met Lys  Pro His Arg 
    3215                 3220                 3225             


Gly Pro  Pro Pro Glu Leu Gln  Pro Gln Pro Glu Gly  Pro Pro Arg 
    3230                 3235                 3240             


Leu Leu  Leu Gly Gly Leu Pro  Glu Ser Gly Thr Ile  Tyr Asn Phe 
    3245                 3250                 3255             


Ser Gly  Cys Ile Ser Asn Val  Phe Val Gln Arg Leu  Leu Gly Pro 
    3260                 3265                 3270             


Gln Arg  Val Phe Asp Leu Gln  Gln Asn Leu Gly Ser  Val Asn Val 
    3275                 3280                 3285             


Ser Thr  Gly Cys Ala Pro Ala  Leu Gln Ala Gln Thr  Pro Gly Leu 
    3290                 3295                 3300             


Gly Pro  Arg Gly Leu Gln Ala  Thr Ala Arg Lys Ala  Ser Arg Arg 
    3305                 3310                 3315             


Ser Arg  Gln Pro Ala Arg His  Pro Ala Cys Met Leu  Pro Pro His 
    3320                 3325                 3330             


Leu Arg  Thr Thr Arg Asp Ser  Tyr Gln Phe Gly Gly  Ser Leu Ser 
    3335                 3340                 3345             


Ser His  Leu Glu Phe Val Gly  Ile Leu Ala Arg His  Arg Asn Trp 
    3350                 3355                 3360             


Pro Ser  Leu Ser Met His Val  Leu Pro Arg Ser Ser  Arg Gly Leu 
    3365                 3370                 3375             


Leu Leu  Phe Thr Ala Arg Leu  Arg Pro Gly Ser Pro  Ser Leu Ala 
    3380                 3385                 3390             


Leu Phe  Leu Ser Asn Gly His  Phe Val Ala Gln Met  Glu Gly Leu 
    3395                 3400                 3405             


Gly Thr  Arg Leu Arg Ala Gln  Ser Arg Gln Arg Ser  Arg Pro Gly 
    3410                 3415                 3420             


Arg Trp  His Lys Val Ser Val  Arg Trp Glu Lys Asn  Arg Ile Leu 
    3425                 3430                 3435             


Leu Val  Thr Asp Gly Ala Arg  Ala Trp Ser Gln Glu  Gly Pro His 
    3440                 3445                 3450             


Arg Gln  His Gln Gly Ala Glu  His Pro Gln Pro His  Thr Leu Phe 
    3455                 3460                 3465             


Val Gly  Gly Leu Pro Ala Ser  Ser His Ser Ser Lys  Leu Pro Val 
    3470                 3475                 3480             


Thr Val  Gly Phe Ser Gly Cys  Val Lys Arg Leu Arg  Leu His Gly 
    3485                 3490                 3495             


Arg Pro  Leu Gly Ala Pro Thr  Arg Met Ala Gly Val  Thr Pro Cys 
    3500                 3505                 3510             


Ile Leu  Gly Pro Leu Glu Ala  Gly Leu Phe Phe Pro  Gly Ser Gly 
    3515                 3520                 3525             


Gly Val  Ile Thr Leu Asp Leu  Pro Gly Ala Thr Leu  Pro Asp Val 
    3530                 3535                 3540             


Gly Leu  Glu Leu Glu Val Arg  Pro Leu Ala Val Thr  Gly Leu Ile 
    3545                 3550                 3555             


Phe His  Leu Gly Gln Ala Arg  Thr Pro Pro Tyr Leu  Gln Leu Gln 
    3560                 3565                 3570             


Val Thr  Glu Lys Gln Val Leu  Leu Arg Ala Asp Asp  Gly Ala Gly 
    3575                 3580                 3585             


Glu Phe  Ser Thr Ser Val Thr  Arg Pro Ser Val Leu  Cys Asp Gly 
    3590                 3595                 3600             


Gln Trp  His Arg Leu Ala Val  Met Lys Ser Gly Asn  Val Leu Arg 
    3605                 3610                 3615             


Leu Glu  Val Asp Ala Gln Ser  Asn His Thr Val Gly  Pro Leu Leu 
    3620                 3625                 3630             


Ala Ala  Ala Ala Gly Ala Pro  Ala Pro Leu Tyr Leu  Gly Gly Leu 
    3635                 3640                 3645             


Pro Glu  Pro Met Ala Val Gln  Pro Trp Pro Pro Ala  Tyr Cys Gly 
    3650                 3655                 3660             


Cys Met  Arg Arg Leu Ala Val  Asn Arg Ser Pro Val  Ala Met Thr 
    3665                 3670                 3675             


Arg Ser  Val Glu Val His Gly  Ala Val Gly Ala Ser  Gly Cys Pro 
    3680                 3685                 3690             


Ala Ala  
    3695 


<210>  6078
<211>  1786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMB1__Homo_sapiens__NP_002282

<400>  6078

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu 
            20                  25                  30          


Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln 
        35                  40                  45              


Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr 
    50                  55                  60                  


Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn 
65                  70                  75                  80  


Ser Gln Asp Pro Tyr His Glu Thr Leu Asn Pro Asp Ser His Leu Ile 
                85                  90                  95      


Glu Asn Val Val Thr Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp 
            100                 105                 110         


Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu 
        115                 120                 125             


Ala Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg 
    130                 135                 140                 


Pro Ala Ala Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp 
145                 150                 155                 160 


Gly Val Tyr Arg Tyr Phe Ala Tyr Asp Cys Glu Ala Ser Phe Pro Gly 
                165                 170                 175     


Ile Ser Thr Gly Pro Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser 
            180                 185                 190         


Arg Tyr Ser Asp Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg 
        195                 200                 205             


Ala Leu Asp Pro Ala Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile 
    210                 215                 220                 


Gln Asn Leu Leu Lys Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu 
225                 230                 235                 240 


His Thr Leu Gly Asp Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu 
                245                 250                 255     


Lys Tyr Tyr Tyr Ala Val Tyr Asp Met Val Val Arg Gly Asn Cys Phe 
            260                 265                 270         


Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly Phe Asn Glu 
        275                 280                 285             


Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg His Asn Thr 
    290                 295                 300                 


Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His Asp Leu Pro 
305                 310                 315                 320 


Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys Lys Cys Asn 
                325                 330                 335     


Cys Asn Glu His Ser Ile Ser Cys His Phe Asp Met Ala Val Tyr Leu 
            340                 345                 350         


Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn 
        355                 360                 365             


Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr Tyr Gln His 
    370                 375                 380                 


Pro Glu Arg Asp Ile Arg Asp Pro Asn Phe Cys Glu Arg Cys Thr Cys 
385                 390                 395                 400 


Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp Ser Tyr Thr Asp 
                405                 410                 415     


Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys Lys Leu Asn Val 
            420                 425                 430         


Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe Tyr Asp Leu Ser 
        435                 440                 445             


Ser Glu Asp Pro Phe Gly Cys Lys Ser Cys Ala Cys Asn Pro Leu Gly 
    450                 455                 460                 


Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr Gly His Cys Tyr 
465                 470                 475                 480 


Cys Lys Arg Leu Val Thr Gly Gln His Cys Asp Gln Cys Leu Pro Glu 
                485                 490                 495     


His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg Pro Cys Asp Cys 
            500                 505                 510         


Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Phe Ala Glu Ser Gly Gln 
        515                 520                 525             


Cys Ser Cys Arg Pro His Met Ile Gly Arg Gln Cys Asn Glu Val Glu 
    530                 535                 540                 


Pro Gly Tyr Tyr Phe Ala Thr Leu Asp His Tyr Leu Tyr Glu Ala Glu 
545                 550                 555                 560 


Glu Ala Asn Leu Gly Pro Gly Val Ser Ile Val Glu Arg Gln Tyr Ile 
                565                 570                 575     


Gln Asp Arg Ile Pro Ser Trp Thr Gly Ala Gly Phe Val Arg Val Pro 
            580                 585                 590         


Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile Pro Tyr Ser Met 
        595                 600                 605             


Glu Tyr Asp Ile Leu Ile Arg Tyr Glu Pro Gln Leu Pro Asp His Trp 
    610                 615                 620                 


Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Arg Ile Pro Thr Ser 
625                 630                 635                 640 


Ser Arg Cys Gly Asn Thr Ile Pro Asp Asp Asp Asn Gln Val Val Ser 
                645                 650                 655     


Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg Pro Val Cys Phe 
            660                 665                 670         


Glu Lys Gly Thr Asn Tyr Thr Val Arg Leu Glu Leu Pro Gln Tyr Thr 
        675                 680                 685             


Ser Ser Asp Ser Asp Val Glu Ser Pro Tyr Thr Leu Ile Asp Ser Leu 
    690                 695                 700                 


Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe Thr Val Gly Gly 
705                 710                 715                 720 


Ser Gly Asp Gly Val Val Thr Asn Ser Ala Trp Glu Thr Phe Gln Arg 
                725                 730                 735     


Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys Thr Pro Met Thr 
            740                 745                 750         


Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala Leu Leu His Gln 
        755                 760                 765             


Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser Leu Ser Ser Val 
    770                 775                 780                 


Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro Asn Val Val Gly 
785                 790                 795                 800 


Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly Phe Gly Pro Ser 
                805                 810                 815     


Gly Cys Lys Pro Cys Glu Cys His Leu Gln Gly Ser Val Asn Ala Phe 
            820                 825                 830         


Cys Asn Pro Val Thr Gly Gln Cys His Cys Phe Gln Gly Val Tyr Ala 
        835                 840                 845             


Arg Gln Cys Asp Arg Cys Leu Pro Gly His Trp Gly Phe Pro Ser Cys 
    850                 855                 860                 


Gln Pro Cys Gln Cys Asn Gly His Ala Asp Asp Cys Asp Pro Val Thr 
865                 870                 875                 880 


Gly Glu Cys Leu Asn Cys Gln Asp Tyr Thr Met Gly His Asn Cys Glu 
                885                 890                 895     


Arg Cys Leu Ala Gly Tyr Tyr Gly Asp Pro Ile Ile Gly Ser Gly Asp 
            900                 905                 910         


His Cys Arg Pro Cys Pro Cys Pro Asp Gly Pro Asp Ser Gly Arg Gln 
        915                 920                 925             


Phe Ala Arg Ser Cys Tyr Gln Asp Pro Val Thr Leu Gln Leu Ala Cys 
    930                 935                 940                 


Val Cys Asp Pro Gly Tyr Ile Gly Ser Arg Cys Asp Asp Cys Ala Ser 
945                 950                 955                 960 


Gly Tyr Phe Gly Asn Pro Ser Glu Val Gly Gly Ser Cys Gln Pro Cys 
                965                 970                 975     


Gln Cys His Asn Asn Ile Asp Thr Thr Asp Pro Glu Ala Cys Asp Lys 
            980                 985                 990         


Glu Thr Gly Arg Cys Leu Lys Cys  Leu Tyr His Thr Glu  Gly Glu His 
        995                 1000                 1005             


Cys Gln  Phe Cys Arg Phe Gly  Tyr Tyr Gly Asp Ala  Leu Gln Gln 
    1010                 1015                 1020             


Asp Cys  Arg Lys Cys Val Cys  Asn Tyr Leu Gly Thr  Val Gln Glu 
    1025                 1030                 1035             


His Cys  Asn Gly Ser Asp Cys  Gln Cys Asp Lys Ala  Thr Gly Gln 
    1040                 1045                 1050             


Cys Leu  Cys Leu Pro Asn Val  Ile Gly Gln Asn Cys  Asp Arg Cys 
    1055                 1060                 1065             


Ala Pro  Asn Thr Trp Gln Leu  Ala Ser Gly Thr Gly  Cys Asp Pro 
    1070                 1075                 1080             


Cys Asn  Cys Asn Ala Ala His  Ser Phe Gly Pro Ser  Cys Asn Glu 
    1085                 1090                 1095             


Phe Thr  Gly Gln Cys Gln Cys  Met Pro Gly Phe Gly  Gly Arg Thr 
    1100                 1105                 1110             


Cys Ser  Glu Cys Gln Glu Leu  Phe Trp Gly Asp Pro  Asp Val Glu 
    1115                 1120                 1125             


Cys Arg  Ala Cys Asp Cys Asp  Pro Arg Gly Ile Glu  Thr Pro Gln 
    1130                 1135                 1140             


Cys Asp  Gln Ser Thr Gly Gln  Cys Val Cys Val Glu  Gly Val Glu 
    1145                 1150                 1155             


Gly Pro  Arg Cys Asp Lys Cys  Thr Arg Gly Tyr Ser  Gly Val Phe 
    1160                 1165                 1170             


Pro Asp  Cys Thr Pro Cys His  Gln Cys Phe Ala Leu  Trp Asp Val 
    1175                 1180                 1185             


Ile Ile  Ala Glu Leu Thr Asn  Arg Thr His Arg Phe  Leu Glu Lys 
    1190                 1195                 1200             


Ala Lys  Ala Leu Lys Ile Ser  Gly Val Ile Gly Pro  Tyr Arg Glu 
    1205                 1210                 1215             


Thr Val  Asp Ser Val Glu Arg  Lys Val Ser Glu Ile  Lys Asp Ile 
    1220                 1225                 1230             


Leu Ala  Gln Ser Pro Ala Ala  Glu Pro Leu Lys Asn  Ile Gly Asn 
    1235                 1240                 1245             


Leu Phe  Glu Glu Ala Glu Lys  Leu Ile Lys Asp Val  Thr Glu Met 
    1250                 1255                 1260             


Met Ala  Gln Val Glu Val Lys  Leu Ser Asp Thr Thr  Ser Gln Ser 
    1265                 1270                 1275             


Asn Ser  Thr Ala Lys Glu Leu  Asp Ser Leu Gln Thr  Glu Ala Glu 
    1280                 1285                 1290             


Ser Leu  Asp Asn Thr Val Lys  Glu Leu Ala Glu Gln  Leu Glu Phe 
    1295                 1300                 1305             


Ile Lys  Asn Ser Asp Ile Arg  Gly Ala Leu Asp Ser  Ile Thr Lys 
    1310                 1315                 1320             


Tyr Phe  Gln Met Ser Leu Glu  Ala Glu Glu Arg Val  Asn Ala Ser 
    1325                 1330                 1335             


Thr Thr  Glu Pro Asn Ser Thr  Val Glu Gln Ser Ala  Leu Met Arg 
    1340                 1345                 1350             


Asp Arg  Val Glu Asp Val Met  Met Glu Arg Glu Ser  Gln Phe Lys 
    1355                 1360                 1365             


Glu Lys  Gln Glu Glu Gln Ala  Arg Leu Leu Asp Glu  Leu Ala Gly 
    1370                 1375                 1380             


Lys Leu  Gln Ser Leu Asp Leu  Ser Ala Ala Ala Glu  Met Thr Cys 
    1385                 1390                 1395             


Gly Thr  Pro Pro Gly Ala Ser  Cys Ser Glu Thr Glu  Cys Gly Gly 
    1400                 1405                 1410             


Pro Asn  Cys Arg Thr Asp Glu  Gly Glu Arg Lys Cys  Gly Gly Pro 
    1415                 1420                 1425             


Gly Cys  Gly Gly Leu Val Thr  Val Ala His Asn Ala  Trp Gln Lys 
    1430                 1435                 1440             


Ala Met  Asp Leu Asp Gln Asp  Val Leu Ser Ala Leu  Ala Glu Val 
    1445                 1450                 1455             


Glu Gln  Leu Ser Lys Met Val  Ser Glu Ala Lys Leu  Arg Ala Asp 
    1460                 1465                 1470             


Glu Ala  Lys Gln Ser Ala Glu  Asp Ile Leu Leu Lys  Thr Asn Ala 
    1475                 1480                 1485             


Thr Lys  Glu Lys Met Asp Lys  Ser Asn Glu Glu Leu  Arg Asn Leu 
    1490                 1495                 1500             


Ile Lys  Gln Ile Arg Asn Phe  Leu Thr Gln Asp Ser  Ala Asp Leu 
    1505                 1510                 1515             


Asp Ser  Ile Glu Ala Val Ala  Asn Glu Val Leu Lys  Met Glu Met 
    1520                 1525                 1530             


Pro Ser  Thr Pro Gln Gln Leu  Gln Asn Leu Thr Glu  Asp Ile Arg 
    1535                 1540                 1545             


Glu Arg  Val Glu Ser Leu Ser  Gln Val Glu Val Ile  Leu Gln His 
    1550                 1555                 1560             


Ser Ala  Ala Asp Ile Ala Arg  Ala Glu Met Leu Leu  Glu Glu Ala 
    1565                 1570                 1575             


Lys Arg  Ala Ser Lys Ser Ala  Thr Asp Val Lys Val  Thr Ala Asp 
    1580                 1585                 1590             


Met Val  Lys Glu Ala Leu Glu  Glu Ala Glu Lys Ala  Gln Val Ala 
    1595                 1600                 1605             


Ala Glu  Lys Ala Ile Lys Gln  Ala Asp Glu Asp Ile  Gln Gly Thr 
    1610                 1615                 1620             


Gln Asn  Leu Leu Thr Ser Ile  Glu Ser Glu Thr Ala  Ala Ser Glu 
    1625                 1630                 1635             


Glu Thr  Leu Phe Asn Ala Ser  Gln Arg Ile Ser Glu  Leu Glu Arg 
    1640                 1645                 1650             


Asn Val  Glu Glu Leu Lys Arg  Lys Ala Ala Gln Asn  Ser Gly Glu 
    1655                 1660                 1665             


Ala Glu  Tyr Ile Glu Lys Val  Val Tyr Thr Val Lys  Gln Ser Ala 
    1670                 1675                 1680             


Glu Asp  Val Lys Lys Thr Leu  Asp Gly Glu Leu Asp  Glu Lys Tyr 
    1685                 1690                 1695             


Lys Lys  Val Glu Asn Leu Ile  Ala Lys Lys Thr Glu  Glu Ser Ala 
    1700                 1705                 1710             


Asp Ala  Arg Arg Lys Ala Glu  Met Leu Gln Asn Glu  Ala Lys Thr 
    1715                 1720                 1725             


Leu Leu  Ala Gln Ala Asn Ser  Lys Leu Gln Leu Leu  Lys Asp Leu 
    1730                 1735                 1740             


Glu Arg  Lys Tyr Glu Asp Asn  Gln Arg Tyr Leu Glu  Asp Lys Ala 
    1745                 1750                 1755             


Gln Glu  Leu Ala Arg Leu Glu  Gly Glu Val Arg Ser  Leu Leu Lys 
    1760                 1765                 1770             


Asp Ile  Ser Gln Lys Val Ala  Val Tyr Ser Thr Cys  Leu 
    1775                 1780                 1785     


<210>  6079
<211>  1798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMB2__Homo_sapiens__NP_002283

<400>  6079

Met Glu Leu Thr Ser Arg Glu Arg Gly Arg Gly Gln Pro Leu Pro Trp 
1               5                   10                  15      


Glu Leu Arg Leu Gly Leu Leu Leu Ser Val Leu Ala Ala Thr Leu Ala 
            20                  25                  30          


Gln Ala Pro Ala Pro Asp Val Pro Gly Cys Ser Arg Gly Ser Cys Tyr 
        35                  40                  45              


Pro Ala Thr Gly Asp Leu Leu Val Gly Arg Ala Asp Arg Leu Thr Ala 
    50                  55                  60                  


Ser Ser Thr Cys Gly Leu Asn Gly Pro Gln Pro Tyr Cys Ile Val Ser 
65                  70                  75                  80  


His Leu Gln Asp Glu Lys Lys Cys Phe Leu Cys Asp Ser Arg Arg Pro 
                85                  90                  95      


Phe Ser Ala Arg Asp Asn Pro His Ser His Arg Ile Gln Asn Val Val 
            100                 105                 110         


Thr Ser Phe Ala Pro Gln Arg Arg Ala Ala Trp Trp Gln Ser Glu Asn 
        115                 120                 125             


Gly Ile Pro Ala Val Thr Ile Gln Leu Asp Leu Glu Ala Glu Phe His 
    130                 135                 140                 


Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg Pro Ala Ala Met 
145                 150                 155                 160 


Leu Val Glu Arg Ser Ala Asp Phe Gly Arg Thr Trp His Val Tyr Arg 
                165                 170                 175     


Tyr Phe Ser Tyr Asp Cys Gly Ala Asp Phe Pro Gly Val Pro Leu Ala 
            180                 185                 190         


Pro Pro Arg His Trp Asp Asp Val Val Cys Glu Ser Arg Tyr Ser Glu 
        195                 200                 205             


Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Tyr Arg Val Leu Asp Pro 
    210                 215                 220                 


Ala Ile Pro Ile Pro Asp Pro Tyr Ser Ser Arg Ile Gln Asn Leu Leu 
225                 230                 235                 240 


Lys Ile Thr Asn Leu Arg Val Asn Leu Thr Arg Leu His Thr Leu Gly 
                245                 250                 255     


Asp Asn Leu Leu Asp Pro Arg Arg Glu Ile Arg Glu Lys Tyr Tyr Tyr 
            260                 265                 270         


Ala Leu Tyr Glu Leu Val Val Arg Gly Asn Cys Phe Cys Tyr Gly His 
        275                 280                 285             


Ala Ser Glu Cys Ala Pro Ala Pro Gly Ala Pro Ala His Ala Glu Gly 
    290                 295                 300                 


Met Val His Gly Ala Cys Ile Cys Lys His Asn Thr Arg Gly Leu Asn 
305                 310                 315                 320 


Cys Glu Gln Cys Gln Asp Phe Tyr Arg Asp Leu Pro Trp Arg Pro Ala 
                325                 330                 335     


Glu Asp Gly His Ser His Ala Cys Arg Lys Cys Glu Cys His Gly His 
            340                 345                 350         


Thr His Ser Cys His Phe Asp Met Ala Val Tyr Leu Ala Ser Gly Asn 
        355                 360                 365             


Val Ser Gly Gly Val Cys Asp Gly Cys Gln His Asn Thr Ala Gly Arg 
    370                 375                 380                 


His Cys Glu Leu Cys Arg Pro Phe Phe Tyr Arg Asp Pro Thr Lys Asp 
385                 390                 395                 400 


Leu Arg Asp Pro Ala Val Cys Arg Ser Cys Asp Cys Asp Pro Met Gly 
                405                 410                 415     


Ser Gln Asp Gly Gly Arg Cys Asp Ser His Asp Asp Pro Ala Leu Gly 
            420                 425                 430         


Leu Val Ser Gly Gln Cys Arg Cys Lys Glu His Val Val Gly Thr Arg 
        435                 440                 445             


Cys Gln Gln Cys Arg Asp Gly Phe Phe Gly Leu Ser Ile Ser Asp Arg 
    450                 455                 460                 


Leu Gly Cys Arg Arg Cys Gln Cys Asn Ala Arg Gly Thr Val Pro Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asp Pro Asn Ser Gly Ser Cys Tyr Cys Lys Arg Leu 
                485                 490                 495     


Val Thr Gly Arg Gly Cys Asp Arg Cys Leu Pro Gly His Trp Gly Leu 
            500                 505                 510         


Ser His Asp Leu Leu Gly Cys Arg Pro Cys Asp Cys Asp Val Gly Gly 
        515                 520                 525             


Ala Leu Asp Pro Gln Cys Asp Glu Gly Thr Gly Gln Cys His Cys Arg 
    530                 535                 540                 


Gln His Met Val Gly Arg Arg Cys Glu Gln Val Gln Pro Gly Tyr Phe 
545                 550                 555                 560 


Arg Pro Phe Leu Asp His Leu Ile Trp Glu Ala Glu Asp Thr Arg Gly 
                565                 570                 575     


Gln Val Leu Asp Val Val Glu Arg Leu Val Thr Pro Gly Glu Thr Pro 
            580                 585                 590         


Ser Trp Thr Gly Ser Gly Phe Val Arg Leu Gln Glu Gly Gln Thr Leu 
        595                 600                 605             


Glu Phe Leu Val Ala Ser Val Pro Lys Ala Met Asp Tyr Asp Leu Leu 
    610                 615                 620                 


Leu Arg Leu Glu Pro Gln Val Pro Glu Gln Trp Ala Glu Leu Glu Leu 
625                 630                 635                 640 


Ile Val Gln Arg Pro Gly Pro Val Pro Ala His Ser Leu Cys Gly His 
                645                 650                 655     


Leu Val Pro Lys Asp Asp Arg Ile Gln Gly Thr Leu Gln Pro His Ala 
            660                 665                 670         


Arg Tyr Leu Ile Phe Pro Asn Pro Val Cys Leu Glu Pro Gly Ile Ser 
        675                 680                 685             


Tyr Lys Leu His Leu Lys Leu Val Arg Thr Gly Gly Ser Ala Gln Pro 
    690                 695                 700                 


Glu Thr Pro Tyr Ser Gly Pro Gly Leu Leu Ile Asp Ser Leu Val Leu 
705                 710                 715                 720 


Leu Pro Arg Val Leu Val Leu Glu Met Phe Ser Gly Gly Asp Ala Ala 
                725                 730                 735     


Ala Leu Glu Arg Gln Ala Thr Phe Glu Arg Tyr Gln Cys His Glu Glu 
            740                 745                 750         


Gly Leu Val Pro Ser Lys Thr Ser Pro Ser Glu Ala Cys Ala Pro Leu 
        755                 760                 765             


Leu Ile Ser Leu Ser Thr Leu Ile Tyr Asn Gly Ala Leu Pro Cys Gln 
    770                 775                 780                 


Cys Asn Pro Gln Gly Ser Leu Ser Ser Glu Cys Asn Pro His Gly Gly 
785                 790                 795                 800 


Gln Cys Leu Cys Lys Pro Gly Val Val Gly Arg Arg Cys Asp Leu Cys 
                805                 810                 815     


Ala Pro Gly Tyr Tyr Gly Phe Gly Pro Thr Gly Cys Gln Ala Cys Gln 
            820                 825                 830         


Cys Ser His Glu Gly Ala Leu Ser Ser Leu Cys Glu Lys Thr Ser Gly 
        835                 840                 845             


Gln Cys Leu Cys Arg Thr Gly Ala Phe Gly Leu Arg Cys Asp Arg Cys 
    850                 855                 860                 


Gln Arg Gly Gln Trp Gly Phe Pro Ser Cys Arg Pro Cys Val Cys Asn 
865                 870                 875                 880 


Gly His Ala Asp Glu Cys Asn Thr His Thr Gly Ala Cys Leu Gly Cys 
                885                 890                 895     


Arg Asp His Thr Gly Gly Glu His Cys Glu Arg Cys Ile Ala Gly Phe 
            900                 905                 910         


His Gly Asp Pro Arg Leu Pro Tyr Gly Gly Gln Cys Arg Pro Cys Pro 
        915                 920                 925             


Cys Pro Glu Gly Pro Gly Ser Gln Arg His Phe Ala Thr Ser Cys His 
    930                 935                 940                 


Gln Asp Glu Tyr Ser Gln Gln Ile Val Cys His Cys Arg Ala Gly Tyr 
945                 950                 955                 960 


Thr Gly Leu Arg Cys Glu Ala Cys Ala Pro Gly His Phe Gly Asp Pro 
                965                 970                 975     


Ser Arg Pro Gly Gly Arg Cys Gln Leu Cys Glu Cys Ser Gly Asn Ile 
            980                 985                 990         


Asp Pro Met Asp Pro Asp Ala Cys  Asp Pro His Thr Gly  Gln Cys Leu 
        995                 1000                 1005             


Arg Cys  Leu His His Thr Glu  Gly Pro His Cys Ala  His Cys Lys 
    1010                 1015                 1020             


Pro Gly  Phe His Gly Gln Ala  Ala Arg Gln Ser Cys  His Arg Cys 
    1025                 1030                 1035             


Thr Cys  Asn Leu Leu Gly Thr  Asn Pro Gln Gln Cys  Pro Ser Pro 
    1040                 1045                 1050             


Asp Gln  Cys His Cys Asp Pro  Ser Ser Gly Gln Cys  Pro Cys Leu 
    1055                 1060                 1065             


Pro Asn  Val Gln Gly Pro Ser  Cys Asp Arg Cys Ala  Pro Asn Phe 
    1070                 1075                 1080             


Trp Asn  Leu Thr Ser Gly His  Gly Cys Gln Pro Cys  Ala Cys His 
    1085                 1090                 1095             


Pro Ser  Arg Ala Arg Gly Pro  Thr Cys Asn Glu Phe  Thr Gly Gln 
    1100                 1105                 1110             


Cys His  Cys Arg Ala Gly Phe  Gly Gly Arg Thr Cys  Ser Glu Cys 
    1115                 1120                 1125             


Gln Glu  Leu His Trp Gly Asp  Pro Gly Leu Gln Cys  His Ala Cys 
    1130                 1135                 1140             


Asp Cys  Asp Ser Arg Gly Ile  Asp Thr Pro Gln Cys  His Arg Phe 
    1145                 1150                 1155             


Thr Gly  His Cys Ser Cys Arg  Pro Gly Val Ser Gly  Val Arg Cys 
    1160                 1165                 1170             


Asp Gln  Cys Ala Arg Gly Phe  Ser Gly Ile Phe Pro  Ala Cys His 
    1175                 1180                 1185             


Pro Cys  His Ala Cys Phe Gly  Asp Trp Asp Arg Val  Val Gln Asp 
    1190                 1195                 1200             


Leu Ala  Ala Arg Thr Gln Arg  Leu Glu Gln Arg Ala  Gln Glu Leu 
    1205                 1210                 1215             


Gln Gln  Thr Gly Val Leu Gly  Ala Phe Glu Ser Ser  Phe Trp His 
    1220                 1225                 1230             


Met Gln  Glu Lys Leu Gly Ile  Val Gln Gly Ile Val  Gly Ala Arg 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Ser Thr  Ala Gln Leu Val Glu  Ala Thr Glu 
    1250                 1255                 1260             


Glu Leu  Arg Arg Glu Ile Gly  Glu Ala Thr Glu His  Leu Thr Gln 
    1265                 1270                 1275             


Leu Glu  Ala Asp Leu Thr Asp  Val Gln Asp Glu Asn  Phe Asn Ala 
    1280                 1285                 1290             


Asn His  Ala Leu Ser Gly Leu  Glu Arg Asp Arg Leu  Ala Leu Asn 
    1295                 1300                 1305             


Leu Thr  Leu Arg Gln Leu Asp  Gln His Leu Asp Leu  Leu Lys His 
    1310                 1315                 1320             


Ser Asn  Phe Leu Gly Ala Tyr  Asp Ser Ile Arg His  Ala His Ser 
    1325                 1330                 1335             


Gln Ser  Ala Glu Ala Glu Arg  Arg Ala Asn Thr Ser  Ala Leu Ala 
    1340                 1345                 1350             


Val Pro  Ser Pro Val Ser Asn  Ser Ala Ser Ala Arg  His Arg Thr 
    1355                 1360                 1365             


Glu Ala  Leu Met Asp Ala Gln  Lys Glu Asp Phe Asn  Ser Lys His 
    1370                 1375                 1380             


Met Ala  Asn Gln Arg Ala Leu  Gly Lys Leu Ser Ala  His Thr His 
    1385                 1390                 1395             


Thr Leu  Ser Leu Thr Asp Ile  Asn Glu Leu Val Cys  Gly Ala Pro 
    1400                 1405                 1410             


Gly Asp  Ala Pro Cys Ala Thr  Ser Pro Cys Gly Gly  Ala Gly Cys 
    1415                 1420                 1425             


Arg Asp  Glu Asp Gly Gln Pro  Arg Cys Gly Gly Leu  Ser Cys Asn 
    1430                 1435                 1440             


Gly Ala  Ala Ala Thr Ala Asp  Leu Ala Leu Gly Arg  Ala Arg His 
    1445                 1450                 1455             


Thr Gln  Ala Glu Leu Gln Arg  Ala Leu Ala Glu Gly  Gly Ser Ile 
    1460                 1465                 1470             


Leu Ser  Arg Val Ala Glu Thr  Arg Arg Gln Ala Ser  Glu Ala Gln 
    1475                 1480                 1485             


Gln Arg  Ala Gln Ala Ala Leu  Asp Lys Ala Asn Ala  Ser Arg Gly 
    1490                 1495                 1500             


Gln Val  Glu Gln Ala Asn Gln  Glu Leu Gln Glu Leu  Ile Gln Ser 
    1505                 1510                 1515             


Val Lys  Asp Phe Leu Asn Gln  Glu Gly Ala Asp Pro  Asp Ser Ile 
    1520                 1525                 1530             


Glu Met  Val Ala Thr Arg Val  Leu Glu Leu Ser Ile  Pro Ala Ser 
    1535                 1540                 1545             


Ala Glu  Gln Ile Gln His Leu  Ala Gly Ala Ile Ala  Glu Arg Val 
    1550                 1555                 1560             


Arg Ser  Leu Ala Asp Val Asp  Ala Ile Leu Ala Arg  Thr Val Gly 
    1565                 1570                 1575             


Asp Val  Arg Arg Ala Glu Gln  Leu Leu Gln Asp Ala  Arg Arg Ala 
    1580                 1585                 1590             


Arg Ser  Trp Ala Glu Asp Glu  Lys Gln Lys Ala Glu  Thr Val Gln 
    1595                 1600                 1605             


Ala Ala  Leu Glu Glu Ala Gln  Arg Ala Gln Gly Ile  Ala Gln Gly 
    1610                 1615                 1620             


Ala Ile  Arg Gly Ala Val Ala  Asp Thr Arg Asp Thr  Glu Gln Thr 
    1625                 1630                 1635             


Leu Tyr  Gln Val Gln Glu Arg  Met Ala Gly Ala Glu  Arg Ala Leu 
    1640                 1645                 1650             


Ser Ser  Ala Gly Glu Arg Ala  Arg Gln Leu Asp Ala  Leu Leu Glu 
    1655                 1660                 1665             


Ala Leu  Lys Leu Lys Arg Ala  Gly Asn Ser Leu Ala  Ala Ser Thr 
    1670                 1675                 1680             


Ala Glu  Glu Thr Ala Gly Ser  Ala Gln Gly Arg Ala  Gln Glu Ala 
    1685                 1690                 1695             


Glu Gln  Leu Leu Arg Gly Pro  Leu Gly Asp Gln Tyr  Gln Thr Val 
    1700                 1705                 1710             


Lys Ala  Leu Ala Glu Arg Lys  Ala Gln Gly Val Leu  Ala Ala Gln 
    1715                 1720                 1725             


Ala Arg  Ala Glu Gln Leu Arg  Asp Glu Ala Arg Asp  Leu Leu Gln 
    1730                 1735                 1740             


Ala Ala  Gln Asp Lys Leu Gln  Arg Leu Gln Glu Leu  Glu Gly Thr 
    1745                 1750                 1755             


Tyr Glu  Glu Asn Glu Arg Ala  Leu Glu Ser Lys Ala  Ala Gln Leu 
    1760                 1765                 1770             


Asp Gly  Leu Glu Ala Arg Met  Arg Ser Val Leu Gln  Ala Ile Asn 
    1775                 1780                 1785             


Leu Gln  Val Gln Ile Tyr Asn  Thr Cys Gln 
    1790                 1795             


<210>  6080
<211>  1172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMB3__Homo_sapiens__NP_001121113

<400>  6080

Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys Val Gln Leu Asn 
            180                 185                 190         


Leu Met Asp Leu Val Ser Gly Ile Pro Ala Thr Gln Ser Gln Lys Ile 
        195                 200                 205             


Gln Glu Val Gly Glu Ile Thr Asn Leu Arg Val Asn Phe Thr Arg Leu 
    210                 215                 220                 


Ala Pro Val Pro Gln Arg Gly Tyr His Pro Pro Ser Ala Tyr Tyr Ala 
225                 230                 235                 240 


Val Ser Gln Leu Arg Leu Gln Gly Ser Cys Phe Cys His Gly His Ala 
                245                 250                 255     


Asp Arg Cys Ala Pro Lys Pro Gly Ala Ser Ala Gly Pro Ser Thr Ala 
            260                 265                 270         


Val Gln Val His Asp Val Cys Val Cys Gln His Asn Thr Ala Gly Pro 
        275                 280                 285             


Asn Cys Glu Arg Cys Ala Pro Phe Tyr Asn Asn Arg Pro Trp Arg Pro 
    290                 295                 300                 


Ala Glu Gly Gln Asp Ala His Glu Cys Gln Arg Cys Asp Cys Asn Gly 
305                 310                 315                 320 


His Ser Glu Thr Cys His Phe Asp Pro Ala Val Phe Ala Ala Ser Gln 
                325                 330                 335     


Gly Ala Tyr Gly Gly Val Cys Asp Asn Cys Arg Asp His Thr Glu Gly 
            340                 345                 350         


Lys Asn Cys Glu Arg Cys Gln Leu His Tyr Phe Arg Asn Arg Arg Pro 
        355                 360                 365             


Gly Ala Ser Ile Gln Glu Thr Cys Ile Ser Cys Glu Cys Asp Pro Asp 
    370                 375                 380                 


Gly Ala Val Pro Gly Ala Pro Cys Asp Pro Val Thr Gly Gln Cys Val 
385                 390                 395                 400 


Cys Lys Glu His Val Gln Gly Glu Arg Cys Asp Leu Cys Lys Pro Gly 
                405                 410                 415     


Phe Thr Gly Leu Thr Tyr Ala Asn Pro Gln Gly Cys His Arg Cys Asp 
            420                 425                 430         


Cys Asn Ile Leu Gly Ser Arg Arg Asp Met Pro Cys Asp Glu Glu Ser 
        435                 440                 445             


Gly Arg Cys Leu Cys Leu Pro Asn Val Val Gly Pro Lys Cys Asp Gln 
    450                 455                 460                 


Cys Ala Pro Tyr His Trp Lys Leu Ala Ser Gly Gln Gly Cys Glu Pro 
465                 470                 475                 480 


Cys Ala Cys Asp Pro His Asn Ser Leu Ser Pro Gln Cys Asn Gln Phe 
                485                 490                 495     


Thr Gly Gln Cys Pro Cys Arg Glu Gly Phe Gly Gly Leu Met Cys Ser 
            500                 505                 510         


Ala Ala Ala Ile Arg Gln Cys Pro Asp Arg Thr Tyr Gly Asp Val Ala 
        515                 520                 525             


Thr Gly Cys Arg Ala Cys Asp Cys Asp Phe Arg Gly Thr Glu Gly Pro 
    530                 535                 540                 


Gly Cys Asp Lys Ala Ser Gly Arg Cys Leu Cys Arg Pro Gly Leu Thr 
545                 550                 555                 560 


Gly Pro Arg Cys Asp Gln Cys Gln Arg Gly Tyr Cys Asn Arg Tyr Pro 
                565                 570                 575     


Val Cys Val Ala Cys His Pro Cys Phe Gln Thr Tyr Asp Ala Asp Leu 
            580                 585                 590         


Arg Glu Gln Ala Leu Arg Phe Gly Arg Leu Arg Asn Ala Thr Ala Ser 
        595                 600                 605             


Leu Trp Ser Gly Pro Gly Leu Glu Asp Arg Gly Leu Ala Ser Arg Ile 
    610                 615                 620                 


Leu Asp Ala Lys Ser Lys Ile Glu Gln Ile Arg Ala Val Leu Ser Ser 
625                 630                 635                 640 


Pro Ala Val Thr Glu Gln Glu Val Ala Gln Val Ala Ser Ala Ile Leu 
                645                 650                 655     


Ser Leu Arg Arg Thr Leu Gln Gly Leu Gln Leu Asp Leu Pro Leu Glu 
            660                 665                 670         


Glu Glu Thr Leu Ser Leu Pro Arg Asp Leu Glu Ser Leu Asp Arg Ser 
        675                 680                 685             


Phe Asn Gly Leu Leu Thr Met Tyr Gln Arg Lys Arg Glu Gln Phe Glu 
    690                 695                 700                 


Lys Ile Ser Ser Ala Asp Pro Ser Gly Ala Phe Arg Met Leu Ser Thr 
705                 710                 715                 720 


Ala Tyr Glu Gln Ser Ala Gln Ala Ala Gln Gln Val Ser Asp Ser Ser 
                725                 730                 735     


Arg Leu Leu Asp Gln Leu Arg Asp Ser Arg Arg Glu Ala Glu Arg Leu 
            740                 745                 750         


Val Arg Gln Ala Gly Gly Gly Gly Gly Thr Gly Ser Pro Lys Leu Val 
        755                 760                 765             


Ala Leu Arg Leu Glu Met Ser Ser Leu Pro Asp Leu Thr Pro Thr Phe 
    770                 775                 780                 


Asn Lys Leu Cys Gly Asn Ser Arg Gln Met Ala Cys Thr Pro Ile Ser 
785                 790                 795                 800 


Cys Pro Gly Glu Leu Cys Pro Gln Asp Asn Gly Thr Ala Cys Gly Ser 
                805                 810                 815     


Arg Cys Arg Gly Val Leu Pro Arg Ala Gly Gly Ala Phe Leu Met Ala 
            820                 825                 830         


Gly Gln Val Ala Glu Gln Leu Arg Gly Phe Asn Ala Gln Leu Gln Arg 
        835                 840                 845             


Thr Arg Gln Met Ile Arg Ala Ala Glu Glu Ser Ala Ser Gln Ile Gln 
    850                 855                 860                 


Ser Ser Ala Gln Arg Leu Glu Thr Gln Val Ser Ala Ser Arg Ser Gln 
865                 870                 875                 880 


Met Glu Glu Asp Val Arg Arg Thr Arg Leu Leu Ile Gln Gln Val Arg 
                885                 890                 895     


Asp Phe Leu Thr Asp Pro Asp Thr Asp Ala Ala Thr Ile Gln Glu Val 
            900                 905                 910         


Ser Glu Ala Val Leu Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
        915                 920                 925             


Leu Gln Lys Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn 
    930                 935                 940                 


Val Asp Leu Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg 
945                 950                 955                 960 


Arg Leu Gln Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val 
                965                 970                 975     


Glu Gly Gln Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val 
            980                 985                 990         


Ala Leu Gln Glu Ala Gln Asp Thr  Met Gln Gly Thr Ser  Arg Ser Leu 
        995                 1000                 1005             


Arg Leu  Ile Gln Asp Arg Val  Ala Glu Val Gln Gln  Val Leu Arg 
    1010                 1015                 1020             


Pro Ala  Glu Lys Leu Val Thr  Ser Met Thr Lys Gln  Leu Gly Asp 
    1025                 1030                 1035             


Phe Trp  Thr Arg Met Glu Glu  Leu Arg His Gln Ala  Arg Gln Gln 
    1040                 1045                 1050             


Gly Ala  Glu Ala Val Gln Ala  Gln Gln Leu Ala Glu  Gly Ala Ser 
    1055                 1060                 1065             


Glu Gln  Ala Leu Ser Ala Gln  Glu Gly Phe Glu Arg  Ile Lys Gln 
    1070                 1075                 1080             


Lys Tyr  Ala Glu Leu Lys Asp  Arg Leu Gly Gln Ser  Ser Met Leu 
    1085                 1090                 1095             


Gly Glu  Gln Gly Ala Arg Ile  Gln Ser Val Lys Thr  Glu Ala Glu 
    1100                 1105                 1110             


Glu Leu  Phe Gly Glu Thr Met  Glu Met Met Asp Arg  Met Lys Asp 
    1115                 1120                 1125             


Met Glu  Leu Glu Leu Leu Arg  Gly Ser Gln Ala Ile  Met Leu Arg 
    1130                 1135                 1140             


Ser Ala  Asp Leu Thr Gly Leu  Glu Lys Arg Val Glu  Gln Ile Arg 
    1145                 1150                 1155             


Asp His  Ile Asn Gly Arg Val  Leu Tyr Tyr Ala Thr  Cys Lys 
    1160                 1165                 1170         


<210>  6081
<211>  1761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMB4__Homo_sapiens__NP_031382

<400>  6081

Met Gln Phe Gln Leu Thr Leu Phe Leu His Leu Gly Trp Leu Ser Tyr 
1               5                   10                  15      


Ser Lys Ala Gln Asp Asp Cys Asn Arg Gly Ala Cys His Pro Thr Thr 
            20                  25                  30          


Gly Asp Leu Leu Val Gly Arg Asn Thr Gln Leu Met Ala Ser Ser Thr 
        35                  40                  45              


Cys Gly Leu Ser Arg Ala Gln Lys Tyr Cys Ile Leu Ser Tyr Leu Glu 
    50                  55                  60                  


Gly Glu Gln Lys Cys Phe Ile Cys Asp Ser Arg Phe Pro Tyr Asp Pro 
65                  70                  75                  80  


Tyr Asp Gln Pro Asn Ser His Thr Ile Glu Asn Val Ile Val Ser Phe 
                85                  90                  95      


Glu Pro Asp Arg Glu Lys Lys Trp Trp Gln Ser Glu Asn Gly Leu Asp 
            100                 105                 110         


His Val Ser Ile Arg Leu Asp Leu Glu Ala Leu Phe Arg Phe Ser His 
        115                 120                 125             


Leu Ile Leu Thr Phe Lys Thr Phe Arg Pro Ala Ala Met Leu Val Glu 
    130                 135                 140                 


Arg Ser Thr Asp Tyr Gly His Asn Trp Lys Val Phe Lys Tyr Phe Ala 
145                 150                 155                 160 


Lys Asp Cys Ala Thr Ser Phe Pro Asn Ile Thr Ser Gly Gln Ala Gln 
                165                 170                 175     


Gly Val Gly Asp Ile Val Cys Asp Ser Lys Tyr Ser Asp Ile Glu Pro 
            180                 185                 190         


Ser Thr Gly Gly Glu Val Val Leu Lys Val Leu Asp Pro Ser Phe Glu 
        195                 200                 205             


Ile Glu Asn Pro Tyr Ser Pro Tyr Ile Gln Asp Leu Val Thr Leu Thr 
    210                 215                 220                 


Asn Leu Arg Ile Asn Phe Thr Lys Leu His Thr Leu Gly Asp Ala Leu 
225                 230                 235                 240 


Leu Gly Arg Arg Gln Asn Asp Ser Leu Asp Lys Tyr Tyr Tyr Ala Leu 
                245                 250                 255     


Tyr Glu Met Ile Val Arg Gly Ser Cys Phe Cys Asn Gly His Ala Ser 
            260                 265                 270         


Glu Cys Arg Pro Met Gln Lys Met Arg Gly Asp Val Phe Ser Pro Pro 
        275                 280                 285             


Gly Met Val His Gly Gln Cys Val Cys Gln His Asn Thr Asp Gly Pro 
    290                 295                 300                 


Asn Cys Glu Arg Cys Lys Asp Phe Phe Gln Asp Ala Pro Trp Arg Pro 
305                 310                 315                 320 


Ala Ala Asp Leu Gln Asp Asn Ala Cys Arg Ser Cys Ser Cys Asn Ser 
                325                 330                 335     


His Ser Ser Arg Cys His Phe Asp Met Thr Thr Tyr Leu Ala Ser Gly 
            340                 345                 350         


Gly Leu Ser Gly Gly Val Cys Glu Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln His Cys Asp Arg Cys Arg Pro Leu Phe Tyr Arg Asp Pro Leu Lys 
    370                 375                 380                 


Thr Ile Ser Asp Pro Tyr Ala Cys Ile Pro Cys Glu Cys Asp Pro Asp 
385                 390                 395                 400 


Gly Thr Ile Ser Gly Gly Ile Cys Val Ser His Ser Asp Pro Ala Leu 
                405                 410                 415     


Gly Ser Val Ala Gly Gln Cys Leu Cys Lys Glu Asn Val Glu Gly Ala 
            420                 425                 430         


Lys Cys Asp Gln Cys Lys Pro Asn His Tyr Gly Leu Ser Ala Thr Asp 
        435                 440                 445             


Pro Leu Gly Cys Gln Pro Cys Asp Cys Asn Pro Leu Gly Ser Leu Pro 
    450                 455                 460                 


Phe Leu Thr Cys Asp Val Asp Thr Gly Gln Cys Leu Cys Leu Ser Tyr 
465                 470                 475                 480 


Val Thr Gly Ala His Cys Glu Glu Cys Thr Val Gly Tyr Trp Gly Leu 
                485                 490                 495     


Gly Asn His Leu His Gly Cys Ser Pro Cys Asp Cys Asp Ile Gly Gly 
            500                 505                 510         


Ala Tyr Ser Asn Val Cys Ser Pro Lys Asn Gly Gln Cys Glu Cys Arg 
        515                 520                 525             


Pro His Val Thr Gly Arg Ser Cys Ser Glu Pro Ala Pro Gly Tyr Phe 
    530                 535                 540                 


Phe Ala Pro Leu Asn Phe Tyr Leu Tyr Glu Ala Glu Glu Ala Thr Thr 
545                 550                 555                 560 


Leu Gln Gly Leu Ala Pro Leu Gly Ser Glu Thr Phe Gly Gln Ser Pro 
                565                 570                 575     


Ala Val His Val Val Leu Gly Glu Pro Val Pro Gly Asn Pro Val Thr 
            580                 585                 590         


Trp Thr Gly Pro Gly Phe Ala Arg Val Leu Pro Gly Ala Gly Leu Arg 
        595                 600                 605             


Phe Ala Val Asn Asn Ile Pro Phe Pro Val Asp Phe Thr Ile Ala Ile 
    610                 615                 620                 


His Tyr Glu Thr Gln Ser Ala Ala Asp Trp Thr Val Gln Ile Val Val 
625                 630                 635                 640 


Asn Pro Pro Gly Gly Ser Glu His Cys Ile Pro Lys Thr Leu Gln Ser 
                645                 650                 655     


Lys Pro Gln Ser Phe Ala Leu Pro Ala Ala Thr Arg Ile Met Leu Leu 
            660                 665                 670         


Pro Thr Pro Ile Cys Leu Glu Pro Asp Val Gln Tyr Ser Ile Asp Val 
        675                 680                 685             


Tyr Phe Ser Gln Pro Leu Gln Gly Glu Ser His Ala His Ser His Val 
    690                 695                 700                 


Leu Val Asp Ser Leu Gly Leu Ile Pro Gln Ile Asn Ser Leu Glu Asn 
705                 710                 715                 720 


Phe Cys Ser Lys Gln Asp Leu Asp Glu Tyr Gln Leu His Asn Cys Val 
                725                 730                 735     


Glu Ile Ala Ser Ala Met Gly Pro Gln Val Leu Pro Gly Ala Cys Glu 
            740                 745                 750         


Arg Leu Ile Ile Ser Met Ser Ala Lys Leu His Asp Gly Ala Val Ala 
        755                 760                 765             


Cys Lys Cys His Pro Gln Gly Ser Val Gly Ser Ser Cys Ser Arg Leu 
    770                 775                 780                 


Gly Gly Gln Cys Gln Cys Lys Pro Leu Val Val Gly Arg Cys Cys Asp 
785                 790                 795                 800 


Arg Cys Ser Thr Gly Ser Tyr Asp Leu Gly His His Gly Cys His Pro 
                805                 810                 815     


Cys His Cys His Pro Gln Gly Ser Lys Asp Thr Val Cys Asp Gln Val 
            820                 825                 830         


Thr Gly Gln Cys Pro Cys His Gly Glu Val Ser Gly Arg Arg Cys Asp 
        835                 840                 845             


Arg Cys Leu Ala Gly Tyr Phe Gly Phe Pro Ser Cys His Pro Cys Pro 
    850                 855                 860                 


Cys Asn Arg Phe Ala Glu Leu Cys Asp Pro Glu Thr Gly Ser Cys Phe 
865                 870                 875                 880 


Asn Cys Gly Gly Phe Thr Thr Gly Arg Asn Cys Glu Arg Cys Ile Asp 
                885                 890                 895     


Gly Tyr Tyr Gly Asn Pro Ser Ser Gly Gln Pro Cys Arg Pro Cys Leu 
            900                 905                 910         


Cys Pro Asp Asp Pro Ser Ser Asn Gln Tyr Phe Ala His Ser Cys Tyr 
        915                 920                 925             


Gln Asn Leu Trp Ser Ser Asp Val Ile Cys Asn Cys Leu Gln Gly Tyr 
    930                 935                 940                 


Thr Gly Thr Gln Cys Gly Glu Cys Ser Thr Gly Phe Tyr Gly Asn Pro 
945                 950                 955                 960 


Arg Ile Ser Gly Ala Pro Cys Gln Pro Cys Ala Cys Asn Asn Asn Ile 
                965                 970                 975     


Asp Val Thr Asp Pro Glu Ser Cys Ser Arg Val Thr Gly Glu Cys Leu 
            980                 985                 990         


Arg Cys Leu His Asn Thr Gln Gly  Ala Asn Cys Gln Leu  Cys Lys Pro 
        995                 1000                 1005             


Gly His  Tyr Gly Ser Ala Leu  Asn Gln Thr Cys Arg  Arg Cys Ser 
    1010                 1015                 1020             


Cys His  Ala Ser Gly Val Ser  Pro Met Glu Cys Pro  Pro Gly Gly 
    1025                 1030                 1035             


Gly Ala  Cys Leu Cys Asp Pro  Val Thr Gly Ala Cys  Pro Cys Leu 
    1040                 1045                 1050             


Pro Asn  Val Thr Gly Leu Ala  Cys Asp Arg Cys Ala  Asp Gly Tyr 
    1055                 1060                 1065             


Trp Asn  Leu Val Pro Gly Arg  Gly Cys Gln Ser Cys  Asp Cys Asp 
    1070                 1075                 1080             


Pro Arg  Thr Ser Gln Ser Ser  His Cys Asp Gln Leu  Thr Gly Gln 
    1085                 1090                 1095             


Cys Pro  Cys Lys Leu Gly Tyr  Gly Gly Lys Arg Cys  Ser Glu Cys 
    1100                 1105                 1110             


Gln Glu  Asn Tyr Tyr Gly Asp  Pro Pro Gly Arg Cys  Ile Pro Cys 
    1115                 1120                 1125             


Asp Cys  Asn Arg Ala Gly Thr  Gln Lys Pro Ile Cys  Asp Pro Asp 
    1130                 1135                 1140             


Thr Gly  Met Cys Arg Cys Arg  Glu Gly Val Ser Gly  Gln Arg Cys 
    1145                 1150                 1155             


Asp Arg  Cys Ala Arg Gly His  Ser Gln Glu Phe Pro  Thr Cys Leu 
    1160                 1165                 1170             


Gln Cys  His Leu Cys Phe Asp  Gln Trp Asp His Thr  Ile Ser Ser 
    1175                 1180                 1185             


Leu Ser  Lys Ala Val Gln Gly  Leu Met Arg Leu Ala  Ala Asn Met 
    1190                 1195                 1200             


Glu Asp  Lys Arg Glu Thr Leu  Pro Val Cys Glu Ala  Asp Phe Lys 
    1205                 1210                 1215             


Asp Leu  Arg Gly Asn Val Ser  Glu Ile Glu Arg Ile  Leu Lys His 
    1220                 1225                 1230             


Pro Val  Phe Pro Ser Gly Lys  Phe Leu Lys Val Lys  Asp Tyr His 
    1235                 1240                 1245             


Asp Ser  Val Arg Arg Gln Ile  Met Gln Leu Asn Glu  Gln Leu Lys 
    1250                 1255                 1260             


Ala Val  Tyr Glu Phe Gln Asp  Leu Lys Asp Thr Ile  Glu Arg Ala 
    1265                 1270                 1275             


Lys Asn  Glu Ala Asp Leu Leu  Leu Glu Asp Leu Gln  Glu Glu Ile 
    1280                 1285                 1290             


Asp Leu  Gln Ser Ser Val Leu  Asn Ala Ser Ile Ala  Asp Ser Ser 
    1295                 1300                 1305             


Glu Asn  Ile Lys Lys Tyr Tyr  His Ile Ser Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys Ile  Asn Glu Thr Ser Ser  Thr Ile Asn Thr Ser  Ala Asn Thr 
    1325                 1330                 1335             


Arg Asn  Asp Leu Leu Thr Ile  Leu Asp Thr Leu Thr  Ser Lys Gly 
    1340                 1345                 1350             


Asn Leu  Ser Leu Glu Arg Leu  Lys Gln Ile Lys Ile  Pro Asp Ile 
    1355                 1360                 1365             


Gln Ile  Leu Asn Glu Lys Val  Cys Gly Asp Pro Gly  Asn Val Pro 
    1370                 1375                 1380             


Cys Val  Pro Leu Pro Cys Gly  Gly Ala Leu Cys Thr  Gly Arg Lys 
    1385                 1390                 1395             


Gly His  Arg Lys Cys Arg Gly  Pro Gly Cys His Gly  Ser Leu Thr 
    1400                 1405                 1410             


Leu Ser  Thr Asn Ala Leu Gln  Lys Ala Gln Glu Ala  Lys Ser Ile 
    1415                 1420                 1425             


Ile Arg  Asn Leu Asp Lys Gln  Val Arg Gly Leu Lys  Asn Gln Ile 
    1430                 1435                 1440             


Glu Ser  Ile Ser Glu Gln Ala  Glu Val Ser Lys Asn  Asn Ala Leu 
    1445                 1450                 1455             


Gln Leu  Arg Glu Lys Leu Gly  Asn Ile Arg Asn Gln  Ser Asp Ser 
    1460                 1465                 1470             


Glu Glu  Glu Asn Ile Asn Leu  Phe Ile Lys Lys Val  Lys Asn Phe 
    1475                 1480                 1485             


Leu Leu  Glu Glu Asn Val Pro  Pro Glu Asp Ile Glu  Lys Val Ala 
    1490                 1495                 1500             


Asn Gly  Val Leu Asp Ile His  Leu Pro Ile Pro Ser  Gln Asn Leu 
    1505                 1510                 1515             


Thr Asp  Glu Leu Val Lys Ile  Gln Lys His Met Gln  Leu Cys Glu 
    1520                 1525                 1530             


Asp Tyr  Arg Thr Asp Glu Asn  Arg Leu Asn Glu Glu  Ala Asp Gly 
    1535                 1540                 1545             


Ala Gln  Lys Leu Leu Val Lys  Ala Lys Ala Ala Glu  Lys Ala Ala 
    1550                 1555                 1560             


Asn Ile  Leu Leu Asn Leu Asp  Lys Thr Leu Asn Gln  Leu Gln Gln 
    1565                 1570                 1575             


Ala Gln  Ile Thr Gln Gly Arg  Ala Asn Ser Thr Ile  Thr Gln Leu 
    1580                 1585                 1590             


Thr Ala  Asn Ile Thr Lys Ile  Lys Lys Asn Val Leu  Gln Ala Glu 
    1595                 1600                 1605             


Asn Gln  Thr Arg Glu Met Lys  Ser Glu Leu Glu Leu  Ala Lys Gln 
    1610                 1615                 1620             


Arg Ser  Gly Leu Glu Asp Gly  Leu Ser Leu Leu Gln  Thr Lys Leu 
    1625                 1630                 1635             


Gln Arg  His Gln Asp His Ala  Val Asn Ala Lys Val  Gln Ala Glu 
    1640                 1645                 1650             


Ser Ala  Gln His Gln Ala Gly  Ser Leu Glu Lys Glu  Phe Val Glu 
    1655                 1660                 1665             


Leu Lys  Lys Gln Tyr Ala Ile  Leu Gln Arg Lys Thr  Ser Thr Thr 
    1670                 1675                 1680             


Gly Leu  Thr Lys Glu Thr Leu  Gly Lys Val Lys Gln  Leu Lys Asp 
    1685                 1690                 1695             


Ala Ala  Glu Lys Leu Ala Gly  Asp Thr Glu Ala Lys  Ile Arg Arg 
    1700                 1705                 1710             


Ile Thr  Asp Leu Glu Arg Lys  Ile Gln Asp Leu Asn  Leu Ser Arg 
    1715                 1720                 1725             


Gln Ala  Lys Ala Asp Gln Leu  Arg Ile Leu Glu Asp  Gln Val Val 
    1730                 1735                 1740             


Ala Ile  Lys Asn Glu Ile Val  Glu Gln Glu Lys Lys  Tyr Ala Arg 
    1745                 1750                 1755             


Cys Tyr  Ser 
    1760     


<210>  6082
<211>  1609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMC1__Homo_sapiens__NP_002284

<400>  6082

Met Arg Gly Ser His Arg Ala Ala Pro Ala Leu Arg Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Val Leu Ala Val Leu Ala Ala Ala Ala Ala Ala Gly Cys 
            20                  25                  30          


Ala Gln Ala Ala Met Asp Glu Cys Thr Asp Glu Gly Gly Arg Pro Gln 
        35                  40                  45              


Arg Cys Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val 
    50                  55                  60                  


Ala Thr Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr 
65                  70                  75                  80  


Gly Val Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln 
                85                  90                  95      


Pro His Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln 
            100                 105                 110         


Ala Asp Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln 
        115                 120                 125             


Tyr Pro Ser Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp 
    130                 135                 140                 


Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe 
145                 150                 155                 160 


Ala Ile Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly 
            180                 185                 190         


Phe Ile Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu 
        195                 200                 205             


Phe Ser Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr 
    210                 215                 220                 


Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu 
225                 230                 235                 240 


Gln Glu Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu 
                245                 250                 255     


Asn Thr Phe Gly Asp Glu Val Phe Asn Asp Pro Lys Val Leu Lys Ser 
            260                 265                 270         


Tyr Tyr Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys 
        275                 280                 285             


Asn Gly His Ala Ser Glu Cys Met Lys Asn Glu Phe Asp Lys Leu Val 
    290                 295                 300                 


Cys Asn Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu 
305                 310                 315                 320 


Pro Phe Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala 
                325                 330                 335     


Ser Glu Cys Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr 
            340                 345                 350         


Phe Asp Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr 
        355                 360                 365             


Asn Cys Gln Asp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Arg Glu 
    370                 375                 380                 


Asn Phe Phe Arg Leu Gly Asn Asn Glu Ala Cys Ser Ser Cys His Cys 
385                 390                 395                 400 


Ser Pro Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys 
                405                 410                 415     


Ser Cys Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro 
            420                 425                 430         


Gly Phe His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp 
        435                 440                 445             


Pro Ser Gly Ser Ile Asp Glu Cys Asn Ile Glu Thr Gly Arg Cys Val 
    450                 455                 460                 


Cys Lys Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly 
465                 470                 475                 480 


Phe Phe Asn Leu Glu Ser Ser Asn Pro Arg Gly Cys Thr Pro Cys Phe 
                485                 490                 495     


Cys Phe Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val 
            500                 505                 510         


Tyr Ser Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Ala 
        515                 520                 525             


Glu Gln Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Glu Arg 
    530                 535                 540                 


Gln Asp Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile 
545                 550                 555                 560 


Ala Pro Ala Lys Phe Leu Gly Lys Gln Val Leu Ser Tyr Gly Gln Asn 
                565                 570                 575     


Leu Ser Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala 
            580                 585                 590         


Glu Asp Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu 
        595                 600                 605             


Ile Ala Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Val 
    610                 615                 620                 


Phe Arg Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Thr 
625                 630                 635                 640 


Pro Phe Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile 
                645                 650                 655     


Arg Gly Thr Tyr Ser Glu Arg Ser Ala Gly Tyr Leu Asp Asp Val Thr 
            660                 665                 670         


Leu Ala Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu 
        675                 680                 685             


Ser Cys Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Met Cys 
    690                 695                 700                 


Leu Ser Gly Tyr Arg Arg Glu Thr Pro Asn Leu Gly Pro Tyr Ser Pro 
705                 710                 715                 720 


Cys Val Leu Cys Ala Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu 
                725                 730                 735     


Thr Gly Val Cys Asn Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu 
            740                 745                 750         


Lys Cys Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Ala Gly Thr Ser Ser 
        755                 760                 765             


Asp Cys Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Val Val 
    770                 775                 780                 


Pro Lys Thr Lys Glu Val Val Cys Thr Asn Cys Pro Thr Gly Thr Thr 
785                 790                 795                 800 


Gly Lys Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu 
                805                 810                 815     


Gly Arg Asn Gly Pro Val Arg Leu Cys Arg Leu Cys Gln Cys Ser Asp 
            820                 825                 830         


Asn Ile Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu 
        835                 840                 845             


Cys Leu Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys 
    850                 855                 860                 


Lys Asp Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys 
865                 870                 875                 880 


Cys Lys Ala Cys Asn Cys Asn Leu Tyr Gly Thr Met Lys Gln Gln Ser 
                885                 890                 895     


Ser Cys Asn Pro Val Thr Gly Gln Cys Glu Cys Leu Pro His Val Thr 
            900                 905                 910         


Gly Gln Asp Cys Gly Ala Cys Asp Pro Gly Phe Tyr Asn Leu Gln Ser 
        915                 920                 925             


Gly Gln Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn 
    930                 935                 940                 


Gly Gln Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile 
945                 950                 955                 960 


Thr Gly Gln His Cys Glu Arg Cys Glu Val Asn His Phe Gly Phe Gly 
                965                 970                 975     


Pro Glu Gly Cys Lys Pro Cys Asp Cys His Pro Glu Gly Ser Leu Ser 
            980                 985                 990         


Leu Gln Cys Lys Asp Asp Gly Arg  Cys Glu Cys Arg Glu  Gly Phe Val 
        995                 1000                 1005             


Gly Asn  Arg Cys Asp Gln Cys  Glu Glu Asn Tyr Phe  Tyr Asn Arg 
    1010                 1015                 1020             


Ser Trp  Pro Gly Cys Gln Glu  Cys Pro Ala Cys Tyr  Arg Leu Val 
    1025                 1030                 1035             


Lys Asp  Lys Val Ala Asp His  Arg Val Lys Leu Gln  Glu Leu Glu 
    1040                 1045                 1050             


Ser Leu  Ile Ala Asn Leu Gly  Thr Gly Asp Glu Met  Val Thr Asp 
    1055                 1060                 1065             


Gln Ala  Phe Glu Asp Arg Leu  Lys Glu Ala Glu Arg  Glu Val Met 
    1070                 1075                 1080             


Asp Leu  Leu Arg Glu Ala Gln  Asp Val Lys Asp Val  Asp Gln Asn 
    1085                 1090                 1095             


Leu Met  Asp Arg Leu Gln Arg  Val Asn Asn Thr Leu  Ser Ser Gln 
    1100                 1105                 1110             


Ile Ser  Arg Leu Gln Asn Ile  Arg Asn Thr Ile Glu  Glu Thr Gly 
    1115                 1120                 1125             


Asn Leu  Ala Glu Gln Ala Arg  Ala His Val Glu Asn  Thr Glu Arg 
    1130                 1135                 1140             


Leu Ile  Glu Ile Ala Ser Arg  Glu Leu Glu Lys Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ala  Asn Val Ser Val Thr  Gln Pro Glu Ser Thr  Gly Asp Pro 
    1160                 1165                 1170             


Asn Asn  Met Thr Leu Leu Ala  Glu Glu Ala Arg Lys  Leu Ala Glu 
    1175                 1180                 1185             


Arg His  Lys Gln Glu Ala Asp  Asp Ile Val Arg Val  Ala Lys Thr 
    1190                 1195                 1200             


Ala Asn  Asp Thr Ser Thr Glu  Ala Tyr Asn Leu Leu  Leu Arg Thr 
    1205                 1210                 1215             


Leu Ala  Gly Glu Asn Gln Thr  Ala Phe Glu Ile Glu  Glu Leu Asn 
    1220                 1225                 1230             


Arg Lys  Tyr Glu Gln Ala Lys  Asn Ile Ser Gln Asp  Leu Glu Lys 
    1235                 1240                 1245             


Gln Ala  Ala Arg Val His Glu  Glu Ala Lys Arg Ala  Gly Asp Lys 
    1250                 1255                 1260             


Ala Val  Glu Ile Tyr Ala Ser  Val Ala Gln Leu Ser  Pro Leu Asp 
    1265                 1270                 1275             


Ser Glu  Thr Leu Glu Asn Glu  Ala Asn Asn Ile Lys  Met Glu Ala 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gln Leu Ile  Asp Gln Lys Leu Lys  Asp Tyr Glu 
    1295                 1300                 1305             


Asp Leu  Arg Glu Asp Met Arg  Gly Lys Glu Leu Glu  Val Lys Asn 
    1310                 1315                 1320             


Leu Leu  Glu Lys Gly Lys Thr  Glu Gln Gln Thr Ala  Asp Gln Leu 
    1325                 1330                 1335             


Leu Ala  Arg Ala Asp Ala Ala  Lys Ala Leu Ala Glu  Glu Ala Ala 
    1340                 1345                 1350             


Lys Lys  Gly Arg Asp Thr Leu  Gln Glu Ala Asn Asp  Ile Leu Asn 
    1355                 1360                 1365             


Asn Leu  Lys Asp Phe Asp Arg  Arg Val Asn Asp Asn  Lys Thr Ala 
    1370                 1375                 1380             


Ala Glu  Glu Ala Leu Arg Lys  Ile Pro Ala Ile Asn  Gln Thr Ile 
    1385                 1390                 1395             


Thr Glu  Ala Asn Glu Lys Thr  Arg Glu Ala Gln Gln  Ala Leu Gly 
    1400                 1405                 1410             


Ser Ala  Ala Ala Asp Ala Thr  Glu Ala Lys Asn Lys  Ala His Glu 
    1415                 1420                 1425             


Ala Glu  Arg Ile Ala Ser Ala  Val Gln Lys Asn Ala  Thr Ser Thr 
    1430                 1435                 1440             


Lys Ala  Glu Ala Glu Arg Thr  Phe Ala Glu Val Thr  Asp Leu Asp 
    1445                 1450                 1455             


Asn Glu  Val Asn Asn Met Leu  Lys Gln Leu Gln Glu  Ala Glu Lys 
    1460                 1465                 1470             


Glu Leu  Lys Arg Lys Gln Asp  Asp Ala Asp Gln Asp  Met Met Met 
    1475                 1480                 1485             


Ala Gly  Met Ala Ser Gln Ala  Ala Gln Glu Ala Glu  Ile Asn Ala 
    1490                 1495                 1500             


Arg Lys  Ala Lys Asn Ser Val  Thr Ser Leu Leu Ser  Ile Ile Asn 
    1505                 1510                 1515             


Asp Leu  Leu Glu Gln Leu Gly  Gln Leu Asp Thr Val  Asp Leu Asn 
    1520                 1525                 1530             


Lys Leu  Asn Glu Ile Glu Gly  Thr Leu Asn Lys Ala  Lys Asp Glu 
    1535                 1540                 1545             


Met Lys  Val Ser Asp Leu Asp  Arg Lys Val Ser Asp  Leu Glu Asn 
    1550                 1555                 1560             


Glu Ala  Lys Lys Gln Glu Ala  Ala Ile Met Asp Tyr  Asn Arg Asp 
    1565                 1570                 1575             


Ile Glu  Glu Ile Met Lys Asp  Ile Arg Asn Leu Glu  Asp Ile Arg 
    1580                 1585                 1590             


Lys Thr  Leu Pro Ser Gly Cys  Phe Asn Thr Pro Ser  Ile Glu Lys 
    1595                 1600                 1605             


Pro 
    


<210>  6083
<211>  1193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMC2__Homo_sapiens__NP_005553

<400>  6083

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210>  6084
<211>  1575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMC3__Homo_sapiens__NP_006050

<400>  6084

Met Ala Ala Ala Ala Leu Leu Leu Gly Leu Ala Leu Leu Ala Pro Arg 
1               5                   10                  15      


Ala Ala Gly Ala Gly Met Gly Ala Cys Tyr Asp Gly Ala Gly Arg Pro 
            20                  25                  30          


Gln Arg Cys Leu Pro Val Phe Glu Asn Ala Ala Phe Gly Arg Leu Ala 
        35                  40                  45              


Gln Ala Ser His Thr Cys Gly Ser Pro Pro Glu Asp Phe Cys Pro His 
    50                  55                  60                  


Val Gly Ala Ala Gly Ala Gly Ala His Cys Gln Arg Cys Asp Ala Ala 
65                  70                  75                  80  


Asp Pro Gln Arg His His Asn Ala Ser Tyr Leu Thr Asp Phe His Ser 
                85                  90                  95      


Gln Asp Glu Ser Thr Trp Trp Gln Ser Pro Ser Met Ala Phe Gly Val 
            100                 105                 110         


Gln Tyr Pro Thr Ser Val Asn Ile Thr Leu Arg Leu Gly Lys Ala Tyr 
        115                 120                 125             


Glu Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser 
    130                 135                 140                 


Phe Ala Ile Tyr Lys Arg Ser Arg Ala Asp Gly Pro Trp Glu Pro Tyr 
145                 150                 155                 160 


Gln Phe Tyr Ser Ala Ser Cys Gln Lys Thr Tyr Gly Arg Pro Glu Gly 
                165                 170                 175     


Gln Tyr Leu Arg Pro Gly Glu Asp Glu Arg Val Ala Phe Cys Thr Ser 
            180                 185                 190         


Glu Phe Ser Asp Ile Ser Pro Leu Ser Gly Gly Asn Val Ala Phe Ser 
        195                 200                 205             


Thr Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Glu Glu Ser Pro Gly 
    210                 215                 220                 


Leu Gln Glu Trp Val Thr Ser Thr Glu Leu Leu Ile Ser Leu Asp Arg 
225                 230                 235                 240 


Leu Asn Thr Phe Gly Asp Asp Ile Phe Lys Asp Pro Lys Val Leu Gln 
                245                 250                 255     


Ser Tyr Tyr Tyr Ala Val Ser Asp Phe Ser Val Gly Gly Arg Cys Lys 
            260                 265                 270         


Cys Asn Gly His Ala Ser Glu Cys Gly Pro Asp Val Ala Gly Gln Leu 
        275                 280                 285             


Ala Cys Arg Cys Gln His Asn Thr Thr Gly Thr Asp Cys Glu Arg Cys 
    290                 295                 300                 


Leu Pro Phe Phe Gln Asp Arg Pro Trp Ala Arg Gly Thr Ala Glu Ala 
305                 310                 315                 320 


Ala His Glu Cys Leu Pro Cys Asn Cys Ser Gly Arg Ser Glu Glu Cys 
                325                 330                 335     


Thr Phe Asp Arg Glu Leu Phe Arg Ser Thr Gly His Gly Gly Arg Cys 
            340                 345                 350         


His His Cys Arg Asp His Thr Ala Gly Pro His Cys Glu Arg Cys Gln 
        355                 360                 365             


Glu Asn Phe Tyr His Trp Asp Pro Arg Met Pro Cys Gln Pro Cys Asp 
    370                 375                 380                 


Cys Gln Ser Ala Gly Ser Leu His Leu Gln Cys Asp Asp Thr Gly Thr 
385                 390                 395                 400 


Cys Ala Cys Lys Pro Thr Val Thr Gly Trp Lys Cys Asp Arg Cys Leu 
                405                 410                 415     


Pro Gly Phe His Ser Leu Ser Glu Gly Gly Cys Arg Pro Cys Thr Cys 
            420                 425                 430         


Asn Pro Ala Gly Ser Leu Asp Thr Cys Asp Pro Arg Ser Gly Arg Cys 
        435                 440                 445             


Pro Cys Lys Glu Asn Val Glu Gly Asn Leu Cys Asp Arg Cys Arg Pro 
    450                 455                 460                 


Gly Thr Phe Asn Leu Gln Pro His Asn Pro Ala Gly Cys Ser Ser Cys 
465                 470                 475                 480 


Phe Cys Tyr Gly His Ser Lys Val Cys Ala Ser Thr Ala Gln Phe Gln 
                485                 490                 495     


Val His His Ile Leu Ser Asp Phe His Gln Gly Ala Glu Gly Trp Trp 
            500                 505                 510         


Ala Arg Ser Val Gly Gly Ser Glu His Pro Pro Gln Trp Ser Pro Asn 
        515                 520                 525             


Gly Val Leu Leu Ser Pro Glu Asp Glu Glu Glu Leu Thr Ala Pro Glu 
    530                 535                 540                 


Lys Phe Leu Gly Asp Gln Arg Phe Ser Tyr Gly Gln Pro Leu Ile Leu 
545                 550                 555                 560 


Thr Phe Arg Val Pro Pro Gly Asp Ser Pro Leu Pro Val Gln Leu Arg 
                565                 570                 575     


Leu Glu Gly Thr Gly Leu Ala Leu Ser Leu Arg His Ser Ser Leu Ser 
            580                 585                 590         


Gly Pro Gln Asp Ala Gly His Pro Arg Glu Val Glu Leu Arg Phe His 
        595                 600                 605             


Leu Gln Glu Thr Ser Glu Asp Val Ala Pro Pro Leu Pro Pro Phe His 
    610                 615                 620                 


Phe Gln Arg Leu Leu Ala Asn Leu Thr Ser Leu Arg Leu Arg Val Ser 
625                 630                 635                 640 


Pro Gly Pro Ser Pro Ala Gly Pro Val Phe Leu Thr Glu Val Arg Leu 
                645                 650                 655     


Thr Ser Ala Arg Pro Gly Leu Ser Pro Pro Ala Ser Trp Val Glu Ile 
            660                 665                 670         


Cys Ser Cys Pro Thr Gly Tyr Thr Gly Gln Phe Cys Glu Ser Cys Ala 
        675                 680                 685             


Pro Gly Tyr Lys Arg Glu Met Pro Gln Gly Gly Pro Tyr Ala Ser Cys 
    690                 695                 700                 


Val Pro Cys Thr Cys Asn Gln His Gly Thr Cys Asp Pro Asn Thr Gly 
705                 710                 715                 720 


Ile Cys Val Cys Ser His His Thr Glu Gly Pro Ser Cys Glu Arg Cys 
                725                 730                 735     


Leu Pro Gly Phe Tyr Gly Asn Pro Phe Ala Gly Gln Ala Asp Asp Cys 
            740                 745                 750         


Gln Pro Cys Pro Cys Pro Gly Gln Ser Ala Cys Thr Thr Ile Pro Glu 
        755                 760                 765             


Ser Arg Glu Val Val Cys Thr His Cys Pro Pro Gly Gln Arg Gly Arg 
    770                 775                 780                 


Arg Cys Glu Val Cys Asp Asp Gly Phe Phe Gly Asp Pro Leu Gly Leu 
785                 790                 795                 800 


Phe Gly His Pro Gln Pro Cys His Gln Cys Gln Cys Ser Gly Asn Val 
                805                 810                 815     


Asp Pro Asn Ala Val Gly Asn Cys Asp Pro Leu Ser Gly His Cys Leu 
            820                 825                 830         


Arg Cys Leu His Asn Thr Thr Gly Asp His Cys Glu His Cys Gln Glu 
        835                 840                 845             


Gly Phe Tyr Gly Ser Ala Leu Ala Pro Arg Pro Ala Asp Lys Cys Met 
    850                 855                 860                 


Pro Cys Ser Cys His Pro Gln Gly Ser Val Ser Glu Gln Met Pro Cys 
865                 870                 875                 880 


Asp Pro Val Thr Gly Gln Cys Ser Cys Leu Pro His Val Thr Ala Arg 
                885                 890                 895     


Asp Cys Ser Arg Cys Tyr Pro Gly Phe Phe Asp Leu Gln Pro Gly Arg 
            900                 905                 910         


Gly Cys Arg Ser Cys Lys Cys His Pro Leu Gly Ser Gln Glu Asp Gln 
        915                 920                 925             


Cys His Pro Lys Thr Gly Gln Cys Thr Cys Arg Pro Gly Val Thr Gly 
    930                 935                 940                 


Gln Ala Cys Asp Arg Cys Gln Leu Gly Phe Phe Gly Phe Ser Ile Lys 
945                 950                 955                 960 


Gly Cys Arg Ala Cys Arg Cys Ser Pro Leu Gly Ala Ala Ser Ala Gln 
                965                 970                 975     


Cys His Glu Asn Gly Thr Cys Val Cys Arg Pro Gly Phe Glu Gly Tyr 
            980                 985                 990         


Lys Cys Asp Arg Cys His Asp Asn  Phe Phe Leu Thr Ala  Asp Gly Thr 
        995                 1000                 1005             


His Cys  Gln Gln Cys Pro Ser  Cys Tyr Ala Leu Val  Lys Glu Glu 
    1010                 1015                 1020             


Ala Ala  Lys Leu Lys Ala Arg  Leu Thr Leu Thr Glu  Gly Trp Leu 
    1025                 1030                 1035             


Gln Gly  Ser Asp Cys Gly Ser  Pro Trp Gly Pro Leu  Asp Ile Leu 
    1040                 1045                 1050             


Leu Gly  Glu Ala Pro Arg Gly  Asp Val Tyr Gln Gly  His His Leu 
    1055                 1060                 1065             


Leu Pro  Gly Ala Arg Glu Ala  Phe Leu Glu Gln Met  Met Ser Leu 
    1070                 1075                 1080             


Glu Gly  Ala Val Lys Ala Ala  Arg Glu Gln Leu Gln  Arg Leu Asn 
    1085                 1090                 1095             


Lys Gly  Ala Arg Cys Ala Gln  Ala Gly Ser Gln Lys  Thr Cys Thr 
    1100                 1105                 1110             


Gln Leu  Ala Asp Leu Glu Ala  Val Leu Glu Ser Ser  Glu Glu Glu 
    1115                 1120                 1125             


Ile Leu  His Ala Ala Ala Ile  Leu Ala Ser Leu Glu  Ile Pro Gln 
    1130                 1135                 1140             


Glu Gly  Pro Ser Gln Pro Thr  Lys Trp Ser His Leu  Ala Thr Glu 
    1145                 1150                 1155             


Ala Arg  Ala Leu Ala Arg Ser  His Arg Asp Thr Ala  Thr Lys Ile 
    1160                 1165                 1170             


Ala Ala  Thr Ala Trp Arg Ala  Leu Leu Ala Ser Asn  Thr Ser Tyr 
    1175                 1180                 1185             


Ala Leu  Leu Trp Asn Leu Leu  Glu Gly Arg Val Ala  Leu Glu Thr 
    1190                 1195                 1200             


Gln Arg  Asp Leu Glu Asp Arg  Tyr Gln Glu Val Gln  Ala Ala Gln 
    1205                 1210                 1215             


Lys Ala  Leu Arg Thr Ala Val  Ala Glu Val Leu Pro  Glu Ala Glu 
    1220                 1225                 1230             


Ser Val  Leu Ala Thr Val Gln  Gln Val Gly Ala Asp  Thr Ala Pro 
    1235                 1240                 1245             


Tyr Leu  Ala Leu Leu Ala Ser  Pro Gly Ala Leu Pro  Gln Lys Ser 
    1250                 1255                 1260             


Arg Ala  Glu Asp Leu Gly Leu  Lys Ala Lys Ala Leu  Glu Lys Thr 
    1265                 1270                 1275             


Val Ala  Ser Trp Gln His Met  Ala Thr Glu Ala Ala  Arg Thr Leu 
    1280                 1285                 1290             


Gln Thr  Ala Ala Gln Ala Thr  Leu Arg Gln Thr Glu  Pro Leu Thr 
    1295                 1300                 1305             


Lys Leu  His Gln Glu Ala Arg  Ala Ala Leu Thr Gln  Ala Ser Ser 
    1310                 1315                 1320             


Ser Val  Gln Ala Ala Thr Val  Thr Val Met Gly Ala  Arg Thr Leu 
    1325                 1330                 1335             


Leu Ala  Asp Leu Glu Gly Met  Lys Leu Gln Phe Pro  Arg Pro Lys 
    1340                 1345                 1350             


Asp Gln  Ala Ala Leu Gln Arg  Lys Ala Asp Ser Val  Ser Asp Arg 
    1355                 1360                 1365             


Leu Leu  Ala Asp Thr Arg Lys  Lys Thr Lys Gln Ala  Glu Arg Met 
    1370                 1375                 1380             


Leu Gly  Asn Ala Ala Pro Leu  Ser Ser Ser Ala Lys  Lys Lys Gly 
    1385                 1390                 1395             


Arg Glu  Ala Glu Val Leu Ala  Lys Asp Ser Ala Lys  Leu Ala Lys 
    1400                 1405                 1410             


Ala Leu  Leu Arg Glu Arg Lys  Gln Ala His Arg Arg  Ala Ser Arg 
    1415                 1420                 1425             


Leu Thr  Ser Gln Thr Gln Ala  Thr Leu Gln Gln Ala  Ser Gln Gln 
    1430                 1435                 1440             


Val Leu  Ala Ser Glu Ala Arg  Arg Gln Glu Leu Glu  Glu Ala Glu 
    1445                 1450                 1455             


Arg Val  Gly Ala Gly Leu Ser  Glu Met Glu Gln Gln  Ile Arg Glu 
    1460                 1465                 1470             


Ser Arg  Ile Ser Leu Glu Lys  Asp Ile Glu Thr Leu  Ser Glu Leu 
    1475                 1480                 1485             


Leu Ala  Arg Leu Gly Ser Leu  Asp Thr His Gln Ala  Pro Ala Gln 
    1490                 1495                 1500             


Ala Leu  Asn Glu Thr Gln Trp  Ala Leu Glu Arg Leu  Arg Leu Gln 
    1505                 1510                 1515             


Leu Gly  Ser Pro Gly Ser Leu  Gln Arg Lys Leu Ser  Leu Leu Glu 
    1520                 1525                 1530             


Gln Glu  Ser Gln Gln Gln Glu  Leu Gln Ile Gln Gly  Phe Glu Ser 
    1535                 1540                 1545             


Asp Leu  Ala Glu Ile Arg Ala  Asp Lys Gln Asn Leu  Glu Ala Ile 
    1550                 1555                 1560             


Leu His  Ser Leu Pro Glu Asn  Cys Ala Ser Trp Gln  
    1565                 1570                 1575 


<210>  6085
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMP1__Homo_sapiens__NP_005552

<400>  6085

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met 
            20                  25                  30          


Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala 
        35                  40                  45              


Ala Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr 
    50                  55                  60                  


Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys 
65                  70                  75                  80  


Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg 
                85                  90                  95      


Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser 
            100                 105                 110         


Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe 
        115                 120                 125             


Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp 
    130                 135                 140                 


Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln 
145                 150                 155                 160 


Val His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln 
                165                 170                 175     


Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu 
            180                 185                 190         


Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro 
        195                 200                 205             


Ser Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu 
225                 230                 235                 240 


Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu 
                245                 250                 255     


Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His 
            260                 265                 270         


Leu Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe 
        275                 280                 285             


Gln Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile 
    290                 295                 300                 


Gln Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala 
305                 310                 315                 320 


Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr 
                325                 330                 335     


Lys Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val 
            340                 345                 350         


Asn Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln 
        355                 360                 365             


Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Met Leu Ile 
    370                 375                 380                 


Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  6086
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMP2__Homo_sapiens__NP_001116078

<400>  6086

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu Cys 
        355                 360                 365             


Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val 
    370                 375                 380                 


Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly 
385                 390                 395                 400 


Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
                405                 410     


<210>  6087
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMP3__Homo_sapiens__NP_055213

<400>  6087

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  6088
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMTOR1__Homo_sapiens__NP_060377

<400>  6088

Met Gly Cys Cys Tyr Ser Ser Glu Asn Glu Asp Ser Asp Gln Asp Arg 
1               5                   10                  15      


Glu Glu Arg Lys Leu Leu Leu Asp Pro Ser Ser Pro Pro Thr Lys Ala 
            20                  25                  30          


Leu Asn Gly Ala Glu Pro Asn Tyr His Ser Leu Pro Ser Ala Arg Thr 
        35                  40                  45              


Asp Glu Gln Ala Leu Leu Ser Ser Ile Leu Ala Lys Thr Ala Ser Asn 
    50                  55                  60                  


Ile Ile Asp Val Ser Ala Ala Asp Ser Gln Gly Met Glu Gln His Glu 
65                  70                  75                  80  


Tyr Met Asp Arg Ala Arg Gln Tyr Ser Thr Arg Leu Ala Val Leu Ser 
                85                  90                  95      


Ser Ser Leu Thr His Trp Lys Lys Leu Pro Pro Leu Pro Ser Leu Thr 
            100                 105                 110         


Ser Gln Pro His Gln Val Leu Ala Ser Glu Pro Ile Pro Phe Ser Asp 
        115                 120                 125             


Leu Gln Gln Val Ser Arg Ile Ala Ala Tyr Ala Tyr Ser Ala Leu Ser 
    130                 135                 140                 


Gln Ile Arg Val Asp Ala Lys Glu Glu Leu Val Val Gln Phe Gly Ile 
145                 150                 155                 160 


Pro 
    


<210>  6089
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMTOR2__Homo_sapiens__NP_001138736

<400>  6089

Met Leu Arg Pro Lys Ala Leu Thr Gln Val Leu Ser Gln Ala Asn Thr 
1               5                   10                  15      


Gly Gly Val Gln Ser Thr Leu Leu Leu Asn Asn Glu Gly Ser Leu Leu 
            20                  25                  30          


Ala Tyr Ser Gly Tyr Gly Asp Thr Asp Ala Arg Val Thr Ala Ala Ile 
        35                  40                  45              


Ala Ser Asn Ile Trp Ala Ala Tyr Asp Arg Asn Gly Asn Gln Ala Phe 
    50                  55                  60                  


Asn Glu Asp Asn Leu Lys Phe Ile Leu Met Asp Cys Met Ala Gln Ala 
65                  70                  75                  80  


Leu Val Gln Tyr Leu Glu Glu Pro Leu Thr Gln Val Ala Ala Ser 
                85                  90                  95  


<210>  6090
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAMTOR3__Homo_sapiens__NP_068805

<400>  6090

Met Ala Asp Asp Leu Lys Arg Phe Leu Tyr Lys Lys Leu Pro Ser Val 
1               5                   10                  15      


Glu Gly Leu His Ala Ile Val Val Ser Asp Arg Asp Gly Val Pro Val 
            20                  25                  30          


Ile Lys Val Ala Asn Asp Asn Ala Pro Glu His Ala Leu Arg Pro Gly 
        35                  40                  45              


Phe Leu Ser Thr Phe Ala Leu Ala Thr Asp Gln Gly Ser Lys Leu Gly 
    50                  55                  60                  


Leu Ser Lys Asn Lys Ser Ile Ile Cys Tyr Tyr Asn Thr Tyr Gln Val 
65                  70                  75                  80  


Val Gln Phe Asn Arg Leu Pro Leu Val Val Ser Phe Ile Ala Ser Ser 
                85                  90                  95      


Ser Ala Asn Thr Gly Leu Ile Val Ser Leu Glu Lys Glu Leu Ala Pro 
            100                 105                 110         


Leu Phe Glu Glu Leu Arg Gln Val Val Glu Val Ser 
        115                 120                 


<210>  6091
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LANCL1__Homo_sapiens__NP_001130047

<400>  6091

Met Ala Gln Arg Ala Phe Pro Asn Pro Tyr Ala Asp Tyr Asn Lys Ser 
1               5                   10                  15      


Leu Ala Glu Gly Tyr Phe Asp Ala Ala Gly Arg Leu Thr Pro Glu Phe 
            20                  25                  30          


Ser Gln Arg Leu Thr Asn Lys Ile Arg Glu Leu Leu Gln Gln Met Glu 
        35                  40                  45              


Arg Gly Leu Lys Ser Ala Asp Pro Arg Asp Gly Thr Gly Tyr Thr Gly 
    50                  55                  60                  


Trp Ala Gly Ile Ala Val Leu Tyr Leu His Leu Tyr Asp Val Phe Gly 
65                  70                  75                  80  


Asp Pro Ala Tyr Leu Gln Leu Ala His Gly Tyr Val Lys Gln Ser Leu 
                85                  90                  95      


Asn Cys Leu Thr Lys Arg Ser Ile Thr Phe Leu Cys Gly Asp Ala Gly 
            100                 105                 110         


Pro Leu Ala Val Ala Ala Val Leu Tyr His Lys Met Asn Asn Glu Lys 
        115                 120                 125             


Gln Ala Glu Asp Cys Ile Thr Arg Leu Ile His Leu Asn Lys Ile Asp 
    130                 135                 140                 


Pro His Ala Pro Asn Glu Met Leu Tyr Gly Arg Ile Gly Tyr Ile Tyr 
145                 150                 155                 160 


Ala Leu Leu Phe Val Asn Lys Asn Phe Gly Val Glu Lys Ile Pro Gln 
                165                 170                 175     


Ser His Ile Gln Gln Ile Cys Glu Thr Ile Leu Thr Ser Gly Glu Asn 
            180                 185                 190         


Leu Ala Arg Lys Arg Asn Phe Thr Ala Lys Ser Pro Leu Met Tyr Glu 
        195                 200                 205             


Trp Tyr Gln Glu Tyr Tyr Val Gly Ala Ala His Gly Leu Ala Gly Ile 
    210                 215                 220                 


Tyr Tyr Tyr Leu Met Gln Pro Ser Leu Gln Val Ser Gln Gly Lys Leu 
225                 230                 235                 240 


His Ser Leu Val Lys Pro Ser Val Asp Tyr Val Cys Gln Leu Lys Phe 
                245                 250                 255     


Pro Ser Gly Asn Tyr Pro Pro Cys Ile Gly Asp Asn Arg Asp Leu Leu 
            260                 265                 270         


Val His Trp Cys His Gly Ala Pro Gly Val Ile Tyr Met Leu Ile Gln 
        275                 280                 285             


Ala Tyr Lys Val Phe Arg Glu Glu Lys Tyr Leu Cys Asp Ala Tyr Gln 
    290                 295                 300                 


Cys Ala Asp Val Ile Trp Gln Tyr Gly Leu Leu Lys Lys Gly Tyr Gly 
305                 310                 315                 320 


Leu Cys His Gly Ser Ala Gly Asn Ala Tyr Ala Phe Leu Thr Leu Tyr 
                325                 330                 335     


Asn Leu Thr Gln Asp Met Lys Tyr Leu Tyr Arg Ala Cys Lys Phe Ala 
            340                 345                 350         


Glu Trp Cys Leu Glu Tyr Gly Glu His Gly Cys Arg Thr Pro Asp Thr 
        355                 360                 365             


Pro Phe Ser Leu Phe Glu Gly Met Ala Gly Thr Ile Tyr Phe Leu Ala 
    370                 375                 380                 


Asp Leu Leu Val Pro Thr Lys Ala Arg Phe Pro Ala Phe Glu Leu 
385                 390                 395                 


<210>  6092
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LANCL2__Homo_sapiens__NP_061167

<400>  6092

Met Gly Glu Thr Met Ser Lys Arg Leu Lys Leu His Leu Gly Gly Glu 
1               5                   10                  15      


Ala Glu Met Glu Glu Arg Ala Phe Val Asn Pro Phe Pro Asp Tyr Glu 
            20                  25                  30          


Ala Ala Ala Gly Ala Leu Leu Ala Ser Gly Ala Ala Glu Glu Thr Gly 
        35                  40                  45              


Cys Val Arg Pro Pro Ala Thr Thr Asp Glu Pro Gly Leu Pro Phe His 
    50                  55                  60                  


Gln Asp Gly Lys Ile Ile His Asn Phe Ile Arg Arg Ile Gln Thr Lys 
65                  70                  75                  80  


Ile Lys Asp Leu Leu Gln Gln Met Glu Glu Gly Leu Lys Thr Ala Asp 
                85                  90                  95      


Pro His Asp Cys Ser Ala Tyr Thr Gly Trp Thr Gly Ile Ala Leu Leu 
            100                 105                 110         


Tyr Leu Gln Leu Tyr Arg Val Thr Cys Asp Gln Thr Tyr Leu Leu Arg 
        115                 120                 125             


Ser Leu Asp Tyr Val Lys Arg Thr Leu Arg Asn Leu Asn Gly Arg Arg 
    130                 135                 140                 


Val Thr Phe Leu Cys Gly Asp Ala Gly Pro Leu Ala Val Gly Ala Val 
145                 150                 155                 160 


Ile Tyr His Lys Leu Arg Ser Asp Cys Glu Ser Gln Glu Cys Val Thr 
                165                 170                 175     


Lys Leu Leu Gln Leu Gln Arg Ser Val Val Cys Gln Glu Ser Asp Leu 
            180                 185                 190         


Pro Asp Glu Leu Leu Tyr Gly Arg Ala Gly Tyr Leu Tyr Ala Leu Leu 
        195                 200                 205             


Tyr Leu Asn Thr Glu Ile Gly Pro Gly Thr Val Cys Glu Ser Ala Ile 
    210                 215                 220                 


Lys Glu Val Val Asn Ala Ile Ile Glu Ser Gly Lys Thr Leu Ser Arg 
225                 230                 235                 240 


Glu Glu Arg Lys Thr Glu Arg Cys Pro Leu Leu Tyr Gln Trp His Arg 
                245                 250                 255     


Lys Gln Tyr Val Gly Ala Ala His Gly Met Ala Gly Ile Tyr Tyr Met 
            260                 265                 270         


Leu Met Gln Pro Ala Ala Lys Val Asp Gln Glu Thr Leu Thr Glu Met 
        275                 280                 285             


Val Lys Pro Ser Ile Asp Tyr Val Arg His Lys Lys Phe Arg Ser Gly 
    290                 295                 300                 


Asn Tyr Pro Ser Ser Leu Ser Asn Glu Thr Asp Arg Leu Val His Trp 
305                 310                 315                 320 


Cys His Gly Ala Pro Gly Val Ile His Met Leu Met Gln Ala Tyr Lys 
                325                 330                 335     


Val Phe Lys Glu Glu Lys Tyr Leu Lys Glu Ala Met Glu Cys Ser Asp 
            340                 345                 350         


Val Ile Trp Gln Arg Gly Leu Leu Arg Lys Gly Tyr Gly Ile Cys His 
        355                 360                 365             


Gly Thr Ala Gly Asn Gly Tyr Ser Phe Leu Ser Leu Tyr Arg Leu Thr 
    370                 375                 380                 


Gln Asp Lys Lys Tyr Leu Tyr Arg Ala Cys Lys Phe Ala Glu Trp Cys 
385                 390                 395                 400 


Leu Asp Tyr Gly Ala His Gly Cys Arg Ile Pro Asp Arg Pro Tyr Ser 
                405                 410                 415     


Leu Phe Glu Gly Met Ala Gly Ala Ile His Phe Leu Ser Asp Val Leu 
            420                 425                 430         


Gly Pro Glu Thr Ser Arg Phe Pro Ala Phe Glu Leu Asp Ser Ser Lys 
        435                 440                 445             


Arg Asp 
    450 


<210>  6093
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAP3__Homo_sapiens__NP_056991

<400>  6093

Met Phe Leu Leu Pro Leu Pro Ala Ala Gly Arg Val Val Val Arg Arg 
1               5                   10                  15      


Leu Ala Val Arg Arg Phe Gly Ser Arg Ser Leu Ser Thr Ala Asp Met 
            20                  25                  30          


Thr Lys Gly Leu Val Leu Gly Ile Tyr Ser Lys Glu Lys Glu Asp Asp 
        35                  40                  45              


Val Pro Gln Phe Thr Ser Ala Gly Glu Asn Phe Asp Lys Leu Leu Ala 
    50                  55                  60                  


Gly Lys Leu Arg Glu Thr Leu Asn Ile Ser Gly Pro Pro Leu Lys Ala 
65                  70                  75                  80  


Gly Lys Thr Arg Thr Phe Tyr Gly Leu His Gln Asp Phe Pro Ser Val 
                85                  90                  95      


Val Leu Val Gly Leu Gly Lys Lys Ala Ala Gly Ile Asp Glu Gln Glu 
            100                 105                 110         


Asn Trp His Glu Gly Lys Glu Asn Ile Arg Ala Ala Val Ala Ala Gly 
        115                 120                 125             


Cys Arg Gln Ile Gln Asp Leu Glu Leu Ser Ser Val Glu Val Asp Pro 
    130                 135                 140                 


Cys Gly Asp Ala Gln Ala Ala Ala Glu Gly Ala Val Leu Gly Leu Tyr 
145                 150                 155                 160 


Glu Tyr Asp Asp Leu Lys Gln Lys Lys Lys Met Ala Val Ser Ala Lys 
                165                 170                 175     


Leu Tyr Gly Ser Gly Asp Gln Glu Ala Trp Gln Lys Gly Val Leu Phe 
            180                 185                 190         


Ala Ser Gly Gln Asn Leu Ala Arg Gln Leu Met Glu Thr Pro Ala Asn 
        195                 200                 205             


Glu Met Thr Pro Thr Arg Phe Ala Glu Ile Ile Glu Lys Asn Leu Lys 
    210                 215                 220                 


Ser Ala Ser Ser Lys Thr Glu Val His Ile Arg Pro Lys Ser Trp Ile 
225                 230                 235                 240 


Glu Glu Gln Ala Met Gly Ser Phe Leu Ser Val Ala Lys Gly Ser Asp 
                245                 250                 255     


Glu Pro Pro Val Phe Leu Glu Ile His Tyr Lys Gly Ser Pro Asn Ala 
            260                 265                 270         


Asn Glu Pro Pro Leu Val Phe Val Gly Lys Gly Ile Thr Phe Asp Ser 
        275                 280                 285             


Gly Gly Ile Ser Ile Lys Ala Ser Ala Asn Met Asp Leu Met Arg Ala 
    290                 295                 300                 


Asp Met Gly Gly Ala Ala Thr Ile Cys Ser Ala Ile Val Ser Ala Ala 
305                 310                 315                 320 


Lys Leu Asn Leu Pro Ile Asn Ile Ile Gly Leu Ala Pro Leu Cys Glu 
                325                 330                 335     


Asn Met Pro Ser Gly Lys Ala Asn Lys Pro Gly Asp Val Val Arg Ala 
            340                 345                 350         


Lys Asn Gly Lys Thr Ile Gln Val Asp Asn Thr Asp Ala Glu Gly Arg 
        355                 360                 365             


Leu Ile Leu Ala Asp Ala Leu Cys Tyr Ala His Thr Phe Asn Pro Lys 
    370                 375                 380                 


Val Ile Leu Asn Ala Ala Thr Leu Thr Gly Ala Met Asp Val Ala Leu 
385                 390                 395                 400 


Gly Ser Gly Ala Thr Gly Val Phe Thr Asn Ser Ser Trp Leu Trp Asn 
                405                 410                 415     


Lys Leu Phe Glu Ala Ser Ile Glu Thr Gly Asp Arg Val Trp Arg Met 
            420                 425                 430         


Pro Leu Phe Glu His Tyr Thr Arg Gln Val Val Asp Cys Gln Leu Ala 
        435                 440                 445             


Asp Val Asn Asn Ile Gly Lys Tyr Arg Ser Ala Gly Ala Cys Thr Ala 
    450                 455                 460                 


Ala Ala Phe Leu Lys Glu Phe Val Thr His Pro Lys Trp Ala His Leu 
465                 470                 475                 480 


Asp Ile Ala Gly Val Met Thr Asn Lys Asp Glu Val Pro Tyr Leu Arg 
                485                 490                 495     


Lys Gly Met Thr Gly Arg Pro Thr Arg Thr Leu Ile Glu Phe Leu Leu 
            500                 505                 510         


Arg Phe Ser Gln Asp Asn Ala 
        515                 


<210>  6094
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAPTM4B__Homo_sapiens__NP_060877

<400>  6094

Met Thr Ser Arg Thr Arg Val Thr Trp Pro Ser Pro Pro Arg Pro Leu 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala Lys Gly Thr Asp 
            20                  25                  30          


Pro Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 
        35                  40                  45              


Ala His Gly Arg Ala Gly Arg Glu Pro Glu Arg Arg Arg Ser Arg Gln 
    50                  55                  60                  


Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr 
65                  70                  75                  80  


Cys Ala Arg Ala Arg Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 
                85                  90                  95      


Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys Leu Cys Cys His Val 
            100                 105                 110         


Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala 
        115                 120                 125             


Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr 
    130                 135                 140                 


Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp Asp 
145                 150                 155                 160 


Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile 
                165                 170                 175     


Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile 
            180                 185                 190         


Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu 
        195                 200                 205             


Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp Val Met Ser Val 
225                 230                 235                 240 


Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile 
                245                 250                 255     


Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 
            260                 265                 270         


Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val Tyr Val Thr Ser 
        275                 280                 285             


Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 
    290                 295                 300                 


Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val Ser Ala 
305                 310                 315         


<210>  6095
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LARGE__Homo_sapiens__XP_005261889

<400>  6095

Met Leu Gly Ile Cys Arg Gly Arg Arg Lys Phe Leu Ala Ala Ser Leu 
1               5                   10                  15      


Ser Leu Leu Cys Ile Pro Ala Ile Thr Trp Ile Tyr Leu Phe Ser Gly 
            20                  25                  30          


Ser Phe Glu Asp Gly Lys Pro Val Ser Leu Ser Pro Leu Glu Ser Gln 
        35                  40                  45              


Ala His Ser Pro Arg Tyr Thr Ala Ser Ser Gln Arg Glu Arg Glu Ser 
    50                  55                  60                  


Leu Glu Val Arg Met Arg Glu Val Glu Glu Glu Asn Arg Ala Leu Arg 
65                  70                  75                  80  


Arg Gln Leu Ser Leu Ala Gln Gly Arg Ala Pro Ser His Arg Arg Gly 
                85                  90                  95      


Asn His Ser Lys Thr Tyr Ser Met Glu Glu Gly Thr Gly Asp Ser Glu 
            100                 105                 110         


Asn Leu Arg Ala Gly Ile Val Ala Gly Asn Ser Ser Glu Cys Gly Gln 
        115                 120                 125             


Gln Pro Val Val Glu Lys Cys Glu Thr Ile His Val Ala Ile Val Cys 
    130                 135                 140                 


Ala Gly Tyr Asn Ala Ser Arg Asp Val Val Thr Leu Val Lys Ser Val 
145                 150                 155                 160 


Leu Phe His Arg Arg Asn Pro Leu His Phe His Leu Ile Ala Asp Ser 
                165                 170                 175     


Ile Ala Glu Gln Ile Leu Ala Thr Leu Phe Gln Thr Trp Met Val Pro 
            180                 185                 190         


Ala Val Arg Val Asp Phe Tyr Asn Ala Asp Glu Leu Lys Ser Glu Val 
        195                 200                 205             


Ser Trp Ile Pro Asn Lys His Tyr Ser Gly Ile Tyr Gly Leu Met Lys 
    210                 215                 220                 


Leu Val Leu Thr Lys Thr Leu Pro Ala Asn Leu Glu Arg Val Ile Val 
225                 230                 235                 240 


Leu Asp Thr Asp Ile Thr Phe Ala Thr Asp Ile Ala Glu Leu Trp Ala 
                245                 250                 255     


Val Phe His Lys Phe Lys Gly Gln Gln Val Leu Gly Leu Val Glu Asn 
            260                 265                 270         


Gln Ser Asp Trp Tyr Leu Gly Asn Leu Trp Lys Asn His Arg Pro Trp 
        275                 280                 285             


Pro Ala Leu Gly Arg Gly Tyr Asn Thr Gly Val Ile Leu Leu Leu Leu 
    290                 295                 300                 


Asp Lys Leu Arg Lys Met Lys Trp Glu Gln Met Trp Arg Leu Thr Ala 
305                 310                 315                 320 


Glu Arg Glu Leu Met Gly Met Leu Ser Thr Ser Leu Ala Asp Gln Asp 
                325                 330                 335     


Ile Phe Asn Ala Val Ile Lys Gln Asn Pro Phe Leu Val Tyr Gln Leu 
            340                 345                 350         


Pro Cys Phe Trp Asn Val Gln Leu Ser Asp His Thr Arg Ser Glu Gln 
        355                 360                 365             


Cys Tyr Arg Asp Val Ser Asp Leu Lys Val Ile His Trp Asn Ser Pro 
    370                 375                 380                 


Lys Lys Leu Arg Val Lys Asn Lys His Val Glu Phe Phe Arg Asn Leu 
385                 390                 395                 400 


Tyr Leu Thr Phe Leu Glu Tyr Asp Gly Asn Leu Leu Arg Arg Glu Leu 
                405                 410                 415     


Phe Gly Cys Pro Ser Glu Ala Asp Val Asn Ser Glu Asn Leu Gln Lys 
            420                 425                 430         


Gln Leu Ser Glu Leu Asp Glu Asp Asp Leu Cys Tyr Glu Phe Arg Arg 
        435                 440                 445             


Glu Arg Phe Thr Val His Arg Thr His Leu Tyr Phe Leu His Tyr Glu 
    450                 455                 460                 


Tyr Glu Pro Ala Ala Asp Ser Thr Asp Val Thr Leu Val Ala Gln Leu 
465                 470                 475                 480 


Ser Met Asp Arg Leu Gln Met Leu Glu Ala Ile Cys Lys His Trp Glu 
                485                 490                 495     


Gly Pro Ile Ser Leu Ala Leu Tyr Leu Ser Asp Ala Glu Ala Gln Gln 
            500                 505                 510         


Phe Leu Arg Tyr Ala Gln Gly Ser Glu Val Leu Met Ser Arg His Asn 
        515                 520                 525             


Val Gly Tyr His Ile Val Tyr Lys Glu Gly Gln Phe Tyr Pro Val Asn 
    530                 535                 540                 


Leu Leu Arg Asn Val Ala Met Lys His Ile Ser Thr Pro Tyr Met Phe 
545                 550                 555                 560 


Leu Ser Asp Ile Asp Phe Leu Pro Met Tyr Gly Leu Tyr Glu Tyr Leu 
                565                 570                 575     


Arg Lys Ser Val Ile Gln Leu Asp Leu Ala Asn Thr Lys Lys Ala Met 
            580                 585                 590         


Ile Val Pro Ala Phe Glu Thr Leu Arg Tyr Arg Leu Ser Phe Pro Lys 
        595                 600                 605             


Ser Lys Ala Glu Leu Leu Ser Met Leu Asp Met Gly Thr Leu Phe Thr 
    610                 615                 620                 


Phe Arg Tyr His Val Trp Thr Lys Gly His Ala Pro Thr Asn Phe Ala 
625                 630                 635                 640 


Lys Trp Arg Thr Ala Thr Thr Pro Tyr Arg Val Glu Trp Glu Ala Asp 
                645                 650                 655     


Phe Glu Pro Tyr Val Val Val Arg Arg Asp Cys Pro Glu Tyr Asp Arg 
            660                 665                 670         


Arg Phe Val Gly Phe Gly Trp Asn Lys Val Ala His Ile Met Glu Leu 
        675                 680                 685             


Asp Val Gln Glu Tyr Glu Phe Ile Val Leu Pro Asn Ala Tyr Met Ile 
    690                 695                 700                 


His Met Pro His Ala Pro Ser Phe Asp Ile Thr Lys Phe Arg Ser Asn 
705                 710                 715                 720 


Lys Gln Tyr Arg Ile Cys Leu Lys Thr Leu Lys Glu Glu Phe Gln Gln 
                725                 730                 735     


Asp Met Ser Arg Arg Tyr Gly Phe Ala Ala Leu Lys Tyr Leu Thr Ala 
            740                 745                 750         


Glu Asn Asn Ser 
        755     


<210>  6096
<211>  1019
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LARP1__Homo_sapiens__NP_056130

<400>  6096

Met Leu Trp Arg Val Leu Leu Ser Lys Arg Pro Pro Phe Pro His Pro 
1               5                   10                  15      


Glu Leu Asp Phe Gln Glu Ala Pro Ile Pro Ser Cys Pro Gly Arg Leu 
            20                  25                  30          


Pro Gly Arg Lys Asn Ser Val Ala Leu Ala Ala Ala Pro Arg Lys Glu 
        35                  40                  45              


Pro Thr Gly Asp Arg Glu Lys Pro Leu Pro Phe Pro Val Leu Ala Pro 
    50                  55                  60                  


Phe Ser Asn Pro Glu His Ser Ala Pro Ala Lys Val Val Arg Ala Ala 
65                  70                  75                  80  


Val Pro Lys Gln Arg Lys Gly Ser Lys Val Gly Asp Phe Gly Asp Ala 
                85                  90                  95      


Ile Asn Trp Pro Thr Pro Gly Glu Ile Ala His Lys Ser Val Gln Pro 
            100                 105                 110         


Gln Ser His Lys Pro Gln Pro Thr Arg Lys Leu Pro Pro Lys Lys Asp 
        115                 120                 125             


Met Lys Glu Gln Glu Lys Gly Glu Gly Ser Asp Ser Lys Glu Ser Pro 
    130                 135                 140                 


Lys Thr Lys Ser Asp Glu Ser Gly Glu Glu Lys Asn Gly Asp Glu Asp 
145                 150                 155                 160 


Cys Gln Arg Gly Gly Gln Lys Lys Lys Gly Asn Lys His Lys Trp Val 
                165                 170                 175     


Pro Leu Gln Ile Asp Met Lys Pro Glu Val Pro Arg Glu Lys Leu Ala 
            180                 185                 190         


Ser Arg Pro Thr Arg Pro Pro Glu Pro Arg His Ile Pro Ala Asn Arg 
        195                 200                 205             


Gly Glu Ile Lys Gly Ser Glu Ser Ala Thr Tyr Val Pro Val Ala Pro 
    210                 215                 220                 


Pro Thr Pro Ala Trp Gln Pro Glu Ile Lys Pro Glu Pro Ala Trp His 
225                 230                 235                 240 


Asp Gln Asp Glu Thr Ser Ser Val Lys Ser Asp Gly Ala Gly Gly Ala 
                245                 250                 255     


Arg Ala Ser Phe Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
            260                 265                 270         


Arg Gly Arg Gly Gly Thr Arg Thr His Phe Asp Tyr Gln Phe Gly Tyr 
        275                 280                 285             


Arg Lys Phe Asp Gly Val Glu Gly Pro Arg Thr Pro Lys Tyr Met Asn 
    290                 295                 300                 


Asn Ile Thr Tyr Tyr Phe Asp Asn Val Ser Ser Thr Glu Leu Tyr Ser 
305                 310                 315                 320 


Val Asp Gln Glu Leu Leu Lys Asp Tyr Ile Lys Arg Gln Ile Glu Tyr 
                325                 330                 335     


Tyr Phe Ser Val Asp Asn Leu Glu Arg Asp Phe Phe Leu Arg Arg Lys 
            340                 345                 350         


Met Asp Ala Asp Gly Phe Leu Pro Ile Thr Leu Ile Ala Ser Phe His 
        355                 360                 365             


Arg Val Gln Ala Leu Thr Thr Asp Ile Ser Leu Ile Phe Ala Ala Leu 
    370                 375                 380                 


Lys Asp Ser Lys Val Val Glu Ile Val Asp Glu Lys Val Arg Arg Arg 
385                 390                 395                 400 


Glu Glu Pro Glu Lys Trp Pro Leu Pro Pro Ile Val Asp Tyr Ser Gln 
                405                 410                 415     


Thr Asp Phe Ser Gln Leu Leu Asn Cys Pro Glu Phe Val Pro Arg Gln 
            420                 425                 430         


His Tyr Gln Lys Glu Thr Glu Ser Ala Pro Gly Ser Pro Arg Ala Val 
        435                 440                 445             


Thr Pro Val Pro Thr Lys Thr Glu Glu Val Ser Asn Leu Lys Thr Leu 
    450                 455                 460                 


Pro Lys Gly Leu Ser Ala Ser Leu Pro Asp Leu Asp Ser Glu Asn Trp 
465                 470                 475                 480 


Ile Glu Val Lys Lys Arg Pro Arg Pro Ser Pro Ala Arg Pro Lys Lys 
                485                 490                 495     


Ser Glu Glu Ser Arg Phe Ser His Leu Thr Ser Leu Pro Gln Gln Leu 
            500                 505                 510         


Pro Ser Gln Gln Leu Met Ser Lys Asp Gln Asp Glu Gln Glu Glu Leu 
        515                 520                 525             


Asp Phe Leu Phe Asp Glu Glu Met Glu Gln Met Asp Gly Arg Lys Asn 
    530                 535                 540                 


Thr Phe Thr Ala Trp Ser Asp Glu Glu Ser Asp Tyr Glu Ile Asp Asp 
545                 550                 555                 560 


Arg Asp Val Asn Lys Ile Leu Ile Val Thr Gln Thr Pro His Tyr Met 
                565                 570                 575     


Arg Arg His Pro Gly Gly Asp Arg Thr Gly Asn His Thr Ser Arg Ala 
            580                 585                 590         


Lys Met Ser Ala Glu Leu Ala Lys Val Ile Asn Asp Gly Leu Phe Tyr 
        595                 600                 605             


Tyr Glu Gln Asp Leu Trp Ala Glu Lys Phe Glu Pro Glu Tyr Ser Gln 
    610                 615                 620                 


Ile Lys Gln Glu Val Glu Asn Phe Lys Lys Val Asn Met Ile Ser Arg 
625                 630                 635                 640 


Glu Gln Phe Asp Thr Leu Thr Pro Glu Pro Pro Val Asp Pro Asn Gln 
                645                 650                 655     


Glu Val Pro Pro Gly Pro Pro Arg Phe Gln Gln Val Pro Thr Asp Ala 
            660                 665                 670         


Leu Ala Asn Lys Leu Phe Gly Ala Pro Glu Pro Ser Thr Ile Ala Arg 
        675                 680                 685             


Ser Leu Pro Thr Thr Val Pro Glu Ser Pro Asn Tyr Arg Asn Thr Arg 
    690                 695                 700                 


Thr Pro Arg Thr Pro Arg Thr Pro Gln Leu Lys Asp Ser Ser Gln Thr 
705                 710                 715                 720 


Ser Arg Phe Tyr Pro Val Val Lys Glu Gly Arg Thr Leu Asp Ala Lys 
                725                 730                 735     


Met Pro Arg Lys Arg Lys Thr Arg His Ser Ser Asn Pro Pro Leu Glu 
            740                 745                 750         


Ser His Val Gly Trp Val Met Asp Ser Arg Glu His Arg Pro Arg Thr 
        755                 760                 765             


Ala Ser Ile Ser Ser Ser Pro Ser Glu Gly Thr Pro Thr Val Gly Ser 
    770                 775                 780                 


Tyr Gly Cys Thr Pro Gln Ser Leu Pro Lys Phe Gln His Pro Ser His 
785                 790                 795                 800 


Glu Leu Leu Lys Glu Asn Gly Phe Thr Gln His Val Tyr His Lys Tyr 
                805                 810                 815     


Arg Arg Arg Cys Leu Asn Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser 
            820                 825                 830         


Gln Glu Met Asn Thr Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp 
        835                 840                 845             


His Phe Asn Lys Lys Met Tyr Glu Glu Phe Lys Gln Leu Ala Leu Glu 
    850                 855                 860                 


Asp Ala Lys Glu Gly Tyr Arg Tyr Gly Leu Glu Cys Leu Phe Arg Tyr 
865                 870                 875                 880 


Tyr Ser Tyr Gly Leu Glu Lys Lys Phe Arg Leu Asp Ile Phe Lys Asp 
                885                 890                 895     


Phe Gln Glu Glu Thr Val Lys Asp Tyr Glu Ala Gly Gln Leu Tyr Gly 
            900                 905                 910         


Leu Glu Lys Phe Trp Ala Phe Leu Lys Tyr Ser Lys Ala Lys Asn Leu 
        915                 920                 925             


Asp Ile Asp Pro Lys Leu Gln Glu Tyr Leu Gly Lys Phe Arg Arg Leu 
    930                 935                 940                 


Glu Asp Phe Arg Val Asp Pro Pro Met Gly Glu Glu Gly Asn His Lys 
945                 950                 955                 960 


Arg His Ser Val Val Ala Gly Gly Gly Gly Gly Glu Gly Arg Lys Arg 
                965                 970                 975     


Cys Pro Ser Gln Ser Ser Ser Arg Pro Ala Ala Met Ile Ser Gln Pro 
            980                 985                 990         


Pro Thr Pro Pro Thr Gly Gln Pro  Val Arg Glu Asp Ala  Lys Trp Thr 
        995                 1000                 1005             


Ser Gln  His Ser Asn Thr Gln  Thr Leu Gly Lys 
    1010                 1015                 


<210>  6097
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LARP4__Homo_sapiens__NP_001164274

<400>  6097

Met Leu Leu Phe Val Glu Gln Val Ala Ser Lys Gly Thr Gly Leu Asn 
1               5                   10                  15      


Pro Asn Ala Lys Val Trp Gln Glu Ile Ala Pro Gly Asn Thr Asp Ala 
            20                  25                  30          


Thr Pro Val Thr His Gly Thr Glu Ser Ser Trp His Glu Ile Ala Ala 
        35                  40                  45              


Thr Ser Gly Ala His Pro Glu Gly Asn Ala Glu Leu Ser Glu Asp Ile 
    50                  55                  60                  


Cys Lys Glu Tyr Glu Val Met Tyr Ser Ser Ser Cys Glu Thr Thr Arg 
65                  70                  75                  80  


Asn Thr Thr Gly Ile Glu Glu Ser Thr Asp Gly Met Ile Leu Gly Pro 
                85                  90                  95      


Glu Asp Leu Ser Tyr Gln Ile Tyr Asp Val Ser Gly Glu Ser Asn Ser 
            100                 105                 110         


Ala Val Ser Thr Glu Asp Leu Lys Glu Cys Leu Lys Lys Gln Leu Glu 
        115                 120                 125             


Phe Cys Phe Ser Arg Glu Asn Leu Ser Lys Asp Leu Tyr Leu Ile Ser 
    130                 135                 140                 


Gln Met Asp Ser Asp Gln Phe Ile Pro Ile Trp Thr Val Ala Asn Met 
145                 150                 155                 160 


Glu Glu Ile Lys Lys Leu Thr Thr Asp Pro Asp Leu Ile Leu Glu Val 
                165                 170                 175     


Leu Arg Ser Ser Pro Met Val Gln Val Asp Glu Lys Gly Glu Lys Val 
            180                 185                 190         


Arg Pro Ser His Lys Arg Cys Ile Val Ile Leu Arg Glu Ile Pro Glu 
        195                 200                 205             


Thr Thr Pro Ile Glu Glu Val Lys Gly Leu Phe Lys Ser Glu Asn Cys 
    210                 215                 220                 


Pro Lys Val Ile Ser Cys Glu Phe Ala His Asn Ser Asn Trp Tyr Ile 
225                 230                 235                 240 


Thr Phe Gln Ser Asp Thr Asp Ala Gln Gln Ala Phe Lys Tyr Leu Arg 
                245                 250                 255     


Glu Glu Val Lys Thr Phe Gln Gly Lys Pro Ile Met Ala Pro Phe Pro 
            260                 265                 270         


Asn Gly Ser Phe Val Asn Gly Phe Asn Ser Pro Gly Ser Tyr Lys Thr 
        275                 280                 285             


Asn Ala Ala Ala Met Asn Met Gly Arg Pro Phe Gln Lys Asn Arg Arg 
    290                 295                 300                 


Thr Leu Phe Arg Gly Arg Arg Arg Arg Glu Asp Asp Arg Ile Ser Arg 
305                 310                 315                 320 


Pro His Pro Ser Thr Ala Glu Ser Lys Ala Pro Thr Pro Lys Phe Asp 
                325                 330                 335     


Leu Leu Ala Ser Asn Phe Pro Pro Leu Pro Gly Ser Ser Ser Arg Met 
            340                 345                 350         


Pro Gly Glu Leu Val Leu Glu Asn Arg Met Ser Asp Val Val Lys Gly 
        355                 360                 365             


Val Tyr Lys Glu Lys Asp Asn Glu Glu Leu Thr Ile Ser Cys Pro Val 
    370                 375                 380                 


Pro Ala Asp Glu Gln Thr Glu Cys Thr Ser Ala Gln Gln Leu Asn Met 
385                 390                 395                 400 


Ser Thr Ser Ser Pro Cys Ala Ala Glu Leu Thr Ala Leu Ser Thr Thr 
                405                 410                 415     


Gln Gln Glu Lys Asp Leu Ile Glu Asp Ser Ser Val Gln Lys Asp Gly 
            420                 425                 430         


Leu Asn Gln Thr Thr Ile Pro Val Ser Pro Pro Ser Thr Thr Lys Pro 
        435                 440                 445             


Ser Arg Ala Ser Thr Ala Ser Pro Cys Asn Asn Asn Ile Asn Ala Ala 
    450                 455                 460                 


Thr Ala Val Ala Leu Gln Glu Pro Arg Lys Leu Ser Tyr Ala Glu Val 
465                 470                 475                 480 


Cys Gln Lys Pro Pro Lys Glu Pro Ser Ser Val Leu Val Gln Pro Leu 
                485                 490                 495     


Arg Glu Leu Arg Ser Asn Val Val Ser Pro Thr Lys Asn Glu Asp Asn 
            500                 505                 510         


Gly Ala Pro Glu Asn Ser Val Glu Lys Pro His Glu Lys Pro Glu Ala 
        515                 520                 525             


Arg Ala Ser Lys Asp Tyr Ser Gly Phe Arg Gly Asn Ile Ile Pro Arg 
    530                 535                 540                 


Gly Ala Ala Gly Lys Ile Arg Glu Gln Arg Arg Gln Phe Ser His Arg 
545                 550                 555                 560 


Ala Ile Pro Gln Gly Val Thr Arg Arg Asn Gly Lys Glu Gln Tyr Val 
                565                 570                 575     


Pro Pro Arg Ser Pro Lys 
            580         


<210>  6098
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LARP6__Homo_sapiens__NP_060827

<400>  6098

Met Ala Gln Ser Gly Gly Glu Ala Arg Pro Gly Pro Lys Thr Ala Val 
1               5                   10                  15      


Gln Ile Arg Val Ala Ile Gln Glu Ala Glu Asp Val Asp Glu Leu Glu 
            20                  25                  30          


Asp Glu Glu Glu Gly Ala Glu Thr Arg Gly Ala Gly Asp Pro Ala Arg 
        35                  40                  45              


Tyr Leu Ser Pro Gly Trp Gly Ser Ala Ser Glu Glu Glu Pro Ser Arg 
    50                  55                  60                  


Gly His Ser Gly Thr Thr Ala Ser Gly Gly Glu Asn Glu Arg Glu Asp 
65                  70                  75                  80  


Leu Glu Gln Glu Trp Lys Pro Pro Asp Glu Glu Leu Ile Lys Lys Leu 
                85                  90                  95      


Val Asp Gln Ile Glu Phe Tyr Phe Ser Asp Glu Asn Leu Glu Lys Asp 
            100                 105                 110         


Ala Phe Leu Leu Lys His Val Arg Arg Asn Lys Leu Gly Tyr Val Ser 
        115                 120                 125             


Val Lys Leu Leu Thr Ser Phe Lys Lys Val Lys His Leu Thr Arg Asp 
    130                 135                 140                 


Trp Arg Thr Thr Ala His Ala Leu Lys Tyr Ser Val Val Leu Glu Leu 
145                 150                 155                 160 


Asn Glu Asp His Arg Lys Val Arg Arg Thr Thr Pro Val Pro Leu Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Pro Ser Lys Met Leu Leu Val Tyr Asp Leu Tyr 
            180                 185                 190         


Leu Ser Pro Lys Leu Trp Ala Leu Ala Thr Pro Gln Lys Asn Gly Arg 
        195                 200                 205             


Val Gln Glu Lys Val Met Glu His Leu Leu Lys Leu Phe Gly Thr Phe 
    210                 215                 220                 


Gly Val Ile Ser Ser Val Arg Ile Leu Lys Pro Gly Arg Glu Leu Pro 
225                 230                 235                 240 


Pro Asp Ile Arg Arg Ile Ser Ser Arg Tyr Ser Gln Val Gly Thr Gln 
                245                 250                 255     


Glu Cys Ala Ile Val Glu Phe Glu Glu Val Glu Ala Ala Ile Lys Ala 
            260                 265                 270         


His Glu Phe Met Ile Thr Glu Ser Gln Gly Lys Glu Asn Met Lys Ala 
        275                 280                 285             


Val Leu Ile Gly Met Lys Pro Pro Lys Lys Lys Pro Ala Lys Asp Lys 
    290                 295                 300                 


Asn His Asp Glu Glu Pro Thr Ala Ser Ile His Leu Asn Lys Ser Leu 
305                 310                 315                 320 


Asn Lys Arg Val Glu Glu Leu Gln Tyr Met Gly Asp Glu Ser Ser Ala 
                325                 330                 335     


Asn Ser Ser Ser Asp Pro Glu Ser Asn Pro Thr Ser Pro Met Ala Gly 
            340                 345                 350         


Arg Arg His Ala Ala Thr Asn Lys Leu Ser Pro Ser Gly His Gln Asn 
        355                 360                 365             


Leu Phe Leu Ser Pro Asn Ala Ser Pro Cys Thr Ser Pro Trp Ser Ser 
    370                 375                 380                 


Pro Leu Ala Gln Arg Lys Gly Val Ser Arg Lys Ser Pro Leu Ala Glu 
385                 390                 395                 400 


Glu Gly Arg Leu Asn Cys Ser Thr Ser Pro Glu Ile Phe Arg Lys Cys 
                405                 410                 415     


Met Asp Tyr Ser Ser Asp Ser Ser Val Thr Pro Ser Gly Ser Pro Trp 
            420                 425                 430         


Val Arg Arg Arg Arg Gln Ala Glu Met Gly Thr Gln Glu Lys Ser Pro 
        435                 440                 445             


Gly Thr Ser Pro Leu Leu Ser Arg Lys Met Gln Thr Ala Asp Gly Leu 
    450                 455                 460                 


Pro Val Gly Val Leu Arg Leu Pro Arg Gly Pro Asp Asn Thr Arg Gly 
465                 470                 475                 480 


Phe His Gly His Glu Arg Ser Arg Ala Cys Val 
                485                 490     


<210>  6099
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LARP7__Homo_sapiens__NP_001253968

<400>  6099

Met Ile Pro Asn Ile Glu Gly Met Glu Thr Glu Ser Gly Asn Gln Glu 
1               5                   10                  15      


Lys Val Met Glu Glu Glu Ser Thr Glu Lys Lys Lys Glu Val Glu Lys 
            20                  25                  30          


Lys Lys Arg Ser Arg Val Lys Gln Val Leu Ala Asp Ile Ala Lys Gln 
        35                  40                  45              


Val Asp Phe Trp Phe Gly Asp Ala Asn Leu His Lys Asp Arg Phe Leu 
    50                  55                  60                  


Arg Glu Gln Ile Glu Lys Ser Arg Asp Gly Tyr Val Asp Ile Ser Leu 
65                  70                  75                  80  


Leu Val Ser Phe Asn Lys Met Lys Lys Leu Thr Thr Asp Gly Lys Leu 
                85                  90                  95      


Ile Ala Arg Ala Leu Arg Ser Ser Ala Val Val Glu Leu Asp Leu Glu 
            100                 105                 110         


Gly Thr Arg Ile Arg Arg Lys Lys Pro Leu Gly Glu Arg Pro Lys Asp 
        115                 120                 125             


Glu Asp Glu Arg Thr Val Tyr Val Glu Leu Leu Pro Lys Asn Val Asn 
    130                 135                 140                 


His Ser Trp Ile Glu Arg Val Phe Gly Lys Cys Gly Asn Val Val Tyr 
145                 150                 155                 160 


Ile Ser Ile Pro His Tyr Lys Ser Thr Gly Asp Pro Lys Gly Phe Ala 
                165                 170                 175     


Phe Val Glu Phe Glu Thr Lys Glu Gln Ala Ala Lys Ala Ile Glu Phe 
            180                 185                 190         


Leu Asn Asn Pro Pro Glu Glu Ala Pro Arg Lys Pro Gly Ile Phe Pro 
        195                 200                 205             


Lys Thr Val Lys Asn Lys Pro Ile Pro Ala Leu Arg Val Val Glu Glu 
    210                 215                 220                 


Lys Lys Lys Lys Lys Lys Lys Lys Gly Arg Met Lys Lys Glu Asp Asn 
225                 230                 235                 240 


Ile Gln Ala Lys Glu Glu Asn Met Asp Thr Ser Asn Thr Ser Ile Ser 
                245                 250                 255     


Lys Met Lys Arg Ser Arg Pro Thr Ser Glu Gly Ser Asp Ile Glu Ser 
            260                 265                 270         


Thr Glu Pro Gln Lys Gln Cys Ser Lys Lys Lys Lys Lys Arg Asp Arg 
        275                 280                 285             


Val Glu Ala Ser Ser Leu Pro Glu Val Arg Thr Gly Lys Arg Lys Arg 
    290                 295                 300                 


Ser Ser Ser Glu Asp Ala Glu Ser Leu Ala Pro Arg Ser Lys Val Lys 
305                 310                 315                 320 


Lys Ile Ile Gln Lys Asp Ile Ile Lys Glu Ala Ser Glu Ala Ser Lys 
                325                 330                 335     


Glu Asn Arg Asp Ile Glu Ile Ser Thr Glu Glu Glu Lys Asp Thr Gly 
            340                 345                 350         


Asp Leu Lys Asp Ser Ser Leu Leu Lys Thr Lys Arg Lys His Lys Lys 
        355                 360                 365             


Lys His Lys Glu Arg His Lys Met Gly Glu Glu Val Ile Pro Leu Arg 
    370                 375                 380                 


Val Leu Ser Lys Ser Glu Trp Met Asp Leu Lys Lys Glu Tyr Leu Ala 
385                 390                 395                 400 


Leu Gln Lys Ala Ser Met Ala Ser Leu Lys Lys Thr Ile Ser Gln Ile 
                405                 410                 415     


Lys Ser Glu Ser Glu Met Glu Thr Asp Ser Gly Val Pro Gln Asn Thr 
            420                 425                 430         


Gly Met Lys Asn Glu Lys Thr Ala Asn Arg Glu Glu Cys Arg Thr Gln 
        435                 440                 445             


Glu Lys Val Asn Ala Thr Gly Pro Gln Phe Val Ser Gly Val Ile Val 
    450                 455                 460                 


Lys Ile Ile Ser Thr Glu Pro Leu Pro Gly Arg Lys Gln Val Arg Asp 
465                 470                 475                 480 


Thr Leu Ala Ala Ile Ser Glu Val Leu Tyr Val Asp Leu Leu Glu Gly 
                485                 490                 495     


Asp Thr Glu Cys His Ala Arg Phe Lys Thr Pro Glu Asp Ala Gln Ala 
            500                 505                 510         


Val Ile Asn Ala Tyr Thr Glu Ile Asn Lys Lys His Cys Trp Lys Leu 
        515                 520                 525             


Glu Ile Leu Ser Gly Asp His Glu Gln Arg Tyr Trp Gln Lys Ile Leu 
    530                 535                 540                 


Val Asp Arg Gln Ala Lys Leu Asn Gln Pro Arg Glu Lys Lys Arg Gly 
545                 550                 555                 560 


Thr Glu Lys Leu Ile Thr Lys Ala Glu Lys Ile Arg Leu Ala Lys Thr 
                565                 570                 575     


Gln Gln Ala Ser Lys His Ile Arg Phe Ser Glu Tyr Asp 
            580                 585                 


<210>  6100
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LARS2__Homo_sapiens__NP_056155

<400>  6100

Met Ala Ser Val Trp Gln Arg Leu Gly Phe Tyr Ala Ser Leu Leu Lys 
1               5                   10                  15      


Arg Gln Leu Asn Gly Gly Pro Asp Val Ile Lys Trp Glu Arg Arg Val 
            20                  25                  30          


Ile Pro Gly Cys Thr Arg Ser Ile Tyr Ser Ala Thr Gly Lys Trp Thr 
        35                  40                  45              


Lys Glu Tyr Thr Leu Gln Thr Arg Lys Asp Val Glu Lys Trp Trp His 
    50                  55                  60                  


Gln Arg Ile Lys Glu Gln Ala Ser Lys Ile Ser Glu Ala Asp Lys Ser 
65                  70                  75                  80  


Lys Pro Lys Phe Tyr Val Leu Ser Met Phe Pro Tyr Pro Ser Gly Lys 
                85                  90                  95      


Leu His Met Gly His Val Arg Val Tyr Thr Ile Ser Asp Thr Ile Ala 
            100                 105                 110         


Arg Phe Gln Lys Met Arg Gly Met Gln Val Ile Asn Pro Met Gly Trp 
        115                 120                 125             


Asp Ala Phe Gly Leu Pro Ala Glu Asn Ala Ala Val Glu Arg Asn Leu 
    130                 135                 140                 


His Pro Gln Ser Trp Thr Gln Ser Asn Ile Lys His Met Arg Lys Gln 
145                 150                 155                 160 


Leu Asp Arg Leu Gly Leu Cys Phe Ser Trp Asp Arg Glu Ile Thr Thr 
                165                 170                 175     


Cys Leu Pro Asp Tyr Tyr Lys Trp Thr Gln Tyr Leu Phe Ile Lys Leu 
            180                 185                 190         


Tyr Glu Ala Gly Leu Ala Tyr Gln Lys Glu Ala Leu Val Asn Trp Asp 
        195                 200                 205             


Pro Val Asp Gln Thr Val Leu Ala Asn Glu Gln Val Asp Glu His Gly 
    210                 215                 220                 


Cys Ser Trp Arg Ser Gly Ala Lys Val Glu Gln Lys Tyr Leu Arg Gln 
225                 230                 235                 240 


Trp Phe Ile Lys Thr Thr Ala Tyr Ala Lys Ala Met Gln Asp Ala Leu 
                245                 250                 255     


Ala Asp Leu Pro Glu Trp Tyr Gly Ile Lys Gly Met Gln Ala His Trp 
            260                 265                 270         


Ile Gly Asp Cys Val Gly Cys His Leu Asp Phe Thr Leu Lys Val His 
        275                 280                 285             


Gly Gln Ala Thr Gly Glu Lys Leu Thr Ala Tyr Thr Ala Thr Pro Glu 
    290                 295                 300                 


Ala Ile Tyr Gly Thr Ser His Val Ala Ile Ser Pro Ser His Arg Leu 
305                 310                 315                 320 


Leu His Gly His Ser Ser Leu Lys Glu Ala Leu Arg Met Ala Leu Val 
                325                 330                 335     


Pro Gly Lys Asp Cys Leu Thr Pro Val Met Ala Val Asn Met Leu Thr 
            340                 345                 350         


Gln Gln Glu Val Pro Val Val Ile Leu Ala Lys Ala Asp Leu Glu Gly 
        355                 360                 365             


Ser Leu Asp Ser Lys Ile Gly Ile Pro Ser Thr Ser Ser Glu Asp Thr 
    370                 375                 380                 


Ile Leu Ala Gln Thr Leu Gly Leu Ala Tyr Ser Glu Val Ile Glu Thr 
385                 390                 395                 400 


Leu Pro Asp Gly Thr Glu Arg Leu Ser Ser Ser Ala Glu Phe Thr Gly 
                405                 410                 415     


Met Thr Arg Gln Asp Ala Phe Leu Ala Leu Thr Gln Lys Ala Arg Gly 
            420                 425                 430         


Lys Arg Val Gly Gly Asp Val Thr Ser Asp Lys Leu Lys Asp Trp Leu 
        435                 440                 445             


Ile Ser Arg Gln Arg Tyr Trp Gly Thr Pro Ile Pro Ile Val His Cys 
    450                 455                 460                 


Pro Val Cys Gly Pro Thr Pro Val Pro Leu Glu Asp Leu Pro Val Thr 
465                 470                 475                 480 


Leu Pro Asn Ile Ala Ser Phe Thr Gly Lys Gly Gly Pro Pro Leu Ala 
                485                 490                 495     


Met Ala Ser Glu Trp Val Asn Cys Ser Cys Pro Arg Cys Lys Gly Ala 
            500                 505                 510         


Ala Lys Arg Glu Thr Asp Thr Met Asp Thr Phe Val Asp Ser Ala Trp 
        515                 520                 525             


Tyr Tyr Phe Arg Tyr Thr Asp Pro His Asn Pro His Ser Pro Phe Asn 
    530                 535                 540                 


Thr Ala Val Ala Asp Tyr Trp Met Pro Val Asp Leu Tyr Ile Gly Gly 
545                 550                 555                 560 


Lys Glu His Ala Val Met His Leu Phe Tyr Ala Arg Phe Phe Ser His 
                565                 570                 575     


Phe Cys His Asp Gln Lys Met Val Lys His Arg Glu Pro Phe His Lys 
            580                 585                 590         


Leu Leu Ala Gln Gly Leu Ile Lys Gly Gln Thr Phe Arg Leu Pro Ser 
        595                 600                 605             


Gly Gln Tyr Leu Gln Arg Glu Glu Val Asp Leu Thr Gly Ser Val Pro 
    610                 615                 620                 


Val His Ala Lys Thr Lys Glu Lys Leu Glu Val Thr Trp Glu Lys Met 
625                 630                 635                 640 


Ser Lys Ser Lys His Asn Gly Val Asp Pro Glu Glu Val Val Glu Gln 
                645                 650                 655     


Tyr Gly Ile Asp Thr Ile Arg Leu Tyr Ile Leu Phe Ala Ala Pro Pro 
            660                 665                 670         


Glu Lys Asp Ile Leu Trp Asp Val Lys Thr Asp Ala Leu Pro Gly Val 
        675                 680                 685             


Leu Arg Trp Gln Gln Arg Leu Trp Thr Leu Thr Thr Arg Phe Ile Glu 
    690                 695                 700                 


Ala Arg Ala Ser Gly Lys Ser Pro Gln Pro Gln Leu Leu Ser Asn Lys 
705                 710                 715                 720 


Glu Lys Ala Glu Ala Arg Lys Leu Trp Glu Tyr Lys Asn Ser Val Ile 
                725                 730                 735     


Ser Gln Val Thr Thr His Phe Thr Glu Asp Phe Ser Leu Asn Ser Ala 
            740                 745                 750         


Ile Ser Gln Leu Met Gly Leu Ser Asn Ala Leu Ser Gln Ala Ser Gln 
        755                 760                 765             


Ser Val Ile Leu His Ser Pro Glu Phe Glu Asp Ala Leu Cys Ala Leu 
    770                 775                 780                 


Met Val Met Ala Ala Pro Leu Ala Pro His Val Thr Ser Glu Ile Trp 
785                 790                 795                 800 


Ala Gly Leu Ala Leu Val Pro Arg Lys Leu Cys Ala His Tyr Thr Trp 
                805                 810                 815     


Asp Ala Ser Val Leu Leu Gln Ala Trp Pro Ala Val Asp Pro Glu Phe 
            820                 825                 830         


Leu Gln Gln Pro Glu Val Val Gln Met Ala Val Leu Ile Asn Asn Lys 
        835                 840                 845             


Ala Cys Gly Lys Ile Pro Val Pro Gln Gln Val Ala Arg Asp Gln Asp 
    850                 855                 860                 


Lys Val His Glu Phe Val Leu Gln Ser Glu Leu Gly Val Arg Leu Leu 
865                 870                 875                 880 


Gln Gly Arg Ser Ile Lys Lys Ser Phe Leu Ser Pro Arg Thr Ala Leu 
                885                 890                 895     


Ile Asn Phe Leu Val Gln Asp 
            900             


<210>  6101
<211>  1176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LARS__Homo_sapiens__NP_064502

<400>  6101

Met Ala Glu Arg Lys Gly Thr Ala Lys Val Asp Phe Leu Lys Lys Ile 
1               5                   10                  15      


Glu Lys Glu Ile Gln Gln Lys Trp Asp Thr Glu Arg Val Phe Glu Val 
            20                  25                  30          


Asn Ala Ser Asn Leu Glu Lys Gln Thr Ser Lys Gly Lys Tyr Phe Val 
        35                  40                  45              


Thr Phe Pro Tyr Pro Tyr Met Asn Gly Arg Leu His Leu Gly His Thr 
    50                  55                  60                  


Phe Ser Leu Ser Lys Cys Glu Phe Ala Val Gly Tyr Gln Arg Leu Lys 
65                  70                  75                  80  


Gly Lys Cys Cys Leu Phe Pro Phe Gly Leu His Cys Thr Gly Met Pro 
                85                  90                  95      


Ile Lys Ala Cys Ala Asp Lys Leu Lys Arg Glu Ile Glu Leu Tyr Gly 
            100                 105                 110         


Cys Pro Pro Asp Phe Pro Asp Glu Glu Glu Glu Glu Glu Glu Thr Ser 
        115                 120                 125             


Val Lys Thr Glu Asp Ile Ile Ile Lys Asp Lys Ala Lys Gly Lys Lys 
    130                 135                 140                 


Ser Lys Ala Ala Ala Lys Ala Gly Ser Ser Lys Tyr Gln Trp Gly Ile 
145                 150                 155                 160 


Met Lys Ser Leu Gly Leu Ser Asp Glu Glu Ile Val Lys Phe Ser Glu 
                165                 170                 175     


Ala Glu His Trp Leu Asp Tyr Phe Pro Pro Leu Ala Ile Gln Asp Leu 
            180                 185                 190         


Lys Arg Met Gly Leu Lys Val Asp Trp Arg Arg Ser Phe Ile Thr Thr 
        195                 200                 205             


Asp Val Asn Pro Tyr Tyr Asp Ser Phe Val Arg Trp Gln Phe Leu Thr 
    210                 215                 220                 


Leu Arg Glu Arg Asn Lys Ile Lys Phe Gly Lys Arg Tyr Thr Ile Tyr 
225                 230                 235                 240 


Ser Pro Lys Asp Gly Gln Pro Cys Met Asp His Asp Arg Gln Thr Gly 
                245                 250                 255     


Glu Gly Val Gly Pro Gln Glu Tyr Thr Leu Leu Lys Leu Lys Val Leu 
            260                 265                 270         


Glu Pro Tyr Pro Ser Lys Leu Ser Gly Leu Lys Gly Lys Asn Ile Phe 
        275                 280                 285             


Leu Val Ala Ala Thr Leu Arg Pro Glu Thr Met Phe Gly Gln Thr Asn 
    290                 295                 300                 


Cys Trp Val Arg Pro Asp Met Lys Tyr Ile Gly Phe Glu Thr Val Asn 
305                 310                 315                 320 


Gly Asp Ile Phe Ile Cys Thr Gln Lys Ala Ala Arg Asn Met Ser Tyr 
                325                 330                 335     


Gln Gly Phe Thr Lys Asp Asn Gly Val Val Pro Val Val Lys Glu Leu 
            340                 345                 350         


Met Gly Glu Glu Ile Leu Gly Ala Ser Leu Ser Ala Pro Leu Thr Ser 
        355                 360                 365             


Tyr Lys Val Ile Tyr Val Leu Pro Met Leu Thr Ile Lys Glu Asp Lys 
    370                 375                 380                 


Gly Thr Gly Val Val Thr Ser Val Pro Ser Asp Ser Pro Asp Asp Ile 
385                 390                 395                 400 


Ala Ala Leu Arg Asp Leu Lys Lys Lys Gln Ala Leu Arg Ala Lys Tyr 
                405                 410                 415     


Gly Ile Arg Asp Asp Met Val Leu Pro Phe Glu Pro Val Pro Val Ile 
            420                 425                 430         


Glu Ile Pro Gly Phe Gly Asn Leu Ser Ala Val Thr Ile Cys Asp Glu 
        435                 440                 445             


Leu Lys Ile Gln Ser Gln Asn Asp Arg Glu Lys Leu Ala Glu Ala Lys 
    450                 455                 460                 


Glu Lys Ile Tyr Leu Lys Gly Phe Tyr Glu Gly Ile Met Leu Val Asp 
465                 470                 475                 480 


Gly Phe Lys Gly Gln Lys Val Gln Asp Val Lys Lys Thr Ile Gln Lys 
                485                 490                 495     


Lys Met Ile Asp Ala Gly Asp Ala Leu Ile Tyr Met Glu Pro Glu Lys 
            500                 505                 510         


Gln Val Met Ser Arg Ser Ser Asp Glu Cys Val Val Ala Leu Cys Asp 
        515                 520                 525             


Gln Trp Tyr Leu Asp Tyr Gly Glu Glu Asn Trp Lys Lys Gln Thr Ser 
    530                 535                 540                 


Gln Cys Leu Lys Asn Leu Glu Thr Phe Cys Glu Glu Thr Arg Arg Asn 
545                 550                 555                 560 


Phe Glu Ala Thr Leu Gly Trp Leu Gln Glu His Ala Cys Ser Arg Thr 
                565                 570                 575     


Tyr Gly Leu Gly Thr His Leu Pro Trp Asp Glu Gln Trp Leu Ile Glu 
            580                 585                 590         


Ser Leu Ser Asp Ser Thr Ile Tyr Met Ala Phe Tyr Thr Val Ala His 
        595                 600                 605             


Leu Leu Gln Gly Gly Asn Leu His Gly Gln Ala Glu Ser Pro Leu Gly 
    610                 615                 620                 


Ile Arg Pro Gln Gln Met Thr Lys Glu Val Trp Asp Tyr Val Phe Phe 
625                 630                 635                 640 


Lys Glu Ala Pro Phe Pro Lys Thr Gln Ile Ala Lys Glu Lys Leu Asp 
                645                 650                 655     


Gln Leu Lys Gln Glu Phe Glu Phe Trp Tyr Pro Val Asp Leu Arg Val 
            660                 665                 670         


Ser Gly Lys Asp Leu Val Pro Asn His Leu Ser Tyr Tyr Leu Tyr Asn 
        675                 680                 685             


His Val Ala Met Trp Pro Glu Gln Ser Asp Lys Trp Pro Thr Ala Val 
    690                 695                 700                 


Arg Ala Asn Gly His Leu Leu Leu Asn Ser Glu Lys Met Ser Lys Ser 
705                 710                 715                 720 


Thr Gly Asn Phe Leu Thr Leu Thr Gln Ala Ile Asp Lys Phe Ser Ala 
                725                 730                 735     


Asp Gly Met Arg Leu Ala Leu Ala Asp Ala Gly Asp Thr Val Glu Asp 
            740                 745                 750         


Ala Asn Phe Val Glu Ala Met Ala Asp Ala Gly Ile Leu Arg Leu Tyr 
        755                 760                 765             


Thr Trp Val Glu Trp Val Lys Glu Met Val Ala Asn Trp Asp Ser Leu 
    770                 775                 780                 


Arg Ser Gly Pro Ala Ser Thr Phe Asn Asp Arg Val Phe Ala Ser Glu 
785                 790                 795                 800 


Leu Asn Ala Gly Ile Ile Lys Thr Asp Gln Asn Tyr Glu Lys Met Met 
                805                 810                 815     


Phe Lys Glu Ala Leu Lys Thr Gly Phe Phe Glu Phe Gln Ala Ala Lys 
            820                 825                 830         


Asp Lys Tyr Arg Glu Leu Ala Val Glu Gly Met His Arg Glu Leu Val 
        835                 840                 845             


Phe Arg Phe Ile Glu Val Gln Thr Leu Leu Leu Ala Pro Phe Cys Pro 
    850                 855                 860                 


His Leu Cys Glu His Ile Trp Thr Leu Leu Gly Lys Pro Asp Ser Ile 
865                 870                 875                 880 


Met Asn Ala Ser Trp Pro Val Ala Gly Pro Val Asn Glu Val Leu Ile 
                885                 890                 895     


His Ser Ser Gln Tyr Leu Met Glu Val Thr His Asp Leu Arg Leu Arg 
            900                 905                 910         


Leu Lys Asn Tyr Met Met Pro Ala Lys Gly Lys Lys Thr Asp Lys Gln 
        915                 920                 925             


Pro Leu Gln Lys Pro Ser His Cys Thr Ile Tyr Val Ala Lys Asn Tyr 
    930                 935                 940                 


Pro Pro Trp Gln His Thr Thr Leu Ser Val Leu Arg Lys His Phe Glu 
945                 950                 955                 960 


Ala Asn Asn Gly Lys Leu Pro Asp Asn Lys Val Ile Ala Ser Glu Leu 
                965                 970                 975     


Gly Ser Met Pro Glu Leu Lys Lys Tyr Met Lys Lys Val Met Pro Phe 
            980                 985                 990         


Val Ala Met Ile Lys Glu Asn Leu  Glu Lys Met Gly Pro  Arg Ile Leu 
        995                 1000                 1005             


Asp Leu  Gln Leu Glu Phe Asp  Glu Lys Ala Val Leu  Met Glu Asn 
    1010                 1015                 1020             


Ile Val  Tyr Leu Thr Asn Ser  Leu Glu Leu Glu His  Ile Glu Val 
    1025                 1030                 1035             


Lys Phe  Ala Ser Glu Ala Glu  Asp Lys Ile Arg Glu  Asp Cys Cys 
    1040                 1045                 1050             


Pro Gly  Lys Pro Leu Asn Val  Phe Arg Ile Glu Pro  Gly Val Ser 
    1055                 1060                 1065             


Val Ser  Leu Val Asn Pro Gln  Pro Ser Asn Gly His  Phe Ser Thr 
    1070                 1075                 1080             


Lys Ile  Glu Ile Arg Gln Gly  Asp Asn Cys Asp Ser  Ile Ile Arg 
    1085                 1090                 1095             


Arg Leu  Met Lys Met Asn Arg  Gly Ile Lys Asp Leu  Ser Lys Val 
    1100                 1105                 1110             


Lys Leu  Met Arg Phe Asp Asp  Pro Leu Leu Gly Pro  Arg Arg Val 
    1115                 1120                 1125             


Pro Val  Leu Gly Lys Glu Tyr  Thr Glu Lys Thr Pro  Ile Ser Glu 
    1130                 1135                 1140             


His Ala  Val Phe Asn Val Asp  Leu Met Ser Lys Lys  Ile His Leu 
    1145                 1150                 1155             


Thr Glu  Asn Gly Ile Arg Val  Asp Ile Gly Asp Thr  Ile Ile Tyr 
    1160                 1165                 1170             


Leu Val  His 
    1175     


<210>  6102
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAS1L__Homo_sapiens__NP_001164120

<400>  6102

Met Ser Trp Glu Ser Gly Ala Gly Pro Gly Leu Gly Ser Gln Gly Met 
1               5                   10                  15      


Asp Leu Val Trp Ser Ala Trp Tyr Gly Lys Cys Val Lys Gly Lys Gly 
            20                  25                  30          


Ser Leu Pro Leu Ser Ala His Gly Ile Val Val Ala Trp Leu Ser Arg 
        35                  40                  45              


Ala Glu Trp Asp Gln Val Thr Val Tyr Leu Phe Cys Asp Asp His Lys 
    50                  55                  60                  


Leu Gln Arg Tyr Ala Leu Asn Arg Ile Thr Val Trp Arg Ser Arg Ser 
65                  70                  75                  80  


Gly Asn Glu Leu Pro Leu Ala Val Ala Ser Thr Ala Asp Leu Ile Arg 
                85                  90                  95      


Cys Lys Leu Leu Asp Val Thr Gly Gly Leu Gly Thr Asp Glu Leu Arg 
            100                 105                 110         


Leu Leu Tyr Gly Met Ala Leu Val Arg Phe Val Asn Leu Ile Ser Glu 
        115                 120                 125             


Arg Lys Thr Lys Phe Ala Lys Val Pro Leu Lys Cys Leu Ala Gln Glu 
    130                 135                 140                 


Val Asn Ile Pro Asp Trp Ile Val Asp Leu Arg His Glu Leu Thr His 
145                 150                 155                 160 


Lys Lys Met Pro His Ile Asn Asp Cys Arg Arg Gly Cys Tyr Phe Val 
                165                 170                 175     


Leu Asp Trp Leu Gln Lys Thr Tyr Trp Cys Arg Gln Leu Glu Asn Ser 
            180                 185                 190         


Leu Arg Glu Thr Trp Glu Leu Glu Glu Phe Arg Glu Gly Ile Glu Glu 
        195                 200                 205             


Glu Asp Gln Glu Glu Asp Lys Asn Ile Val Val Asp Asp Ile Thr Glu 
    210                 215                 220                 


Gln Lys Pro Glu Pro Gln Asp Asp Gly Lys Ser Thr Glu Ser Asp Val 
225                 230                 235                 240 


Lys Ala Asp Gly Asp Ser Lys Gly Ser Glu Glu Val Asp Ser His Cys 
                245                 250                 255     


Lys Lys Ala Leu Ser His Lys Glu Leu Tyr Glu Arg Ala Arg Glu Leu 
            260                 265                 270         


Leu Val Ser Tyr Glu Glu Glu Gln Phe Thr Val Leu Glu Lys Phe Arg 
        275                 280                 285             


Tyr Leu Pro Lys Ala Ile Lys Ala Trp Asn Asn Pro Ser Pro Arg Val 
    290                 295                 300                 


Glu Cys Val Leu Ala Glu Leu Lys Gly Val Thr Cys Glu Asn Arg Glu 
305                 310                 315                 320 


Ala Val Leu Asp Ala Phe Leu Asp Asp Gly Phe Leu Val Pro Thr Phe 
                325                 330                 335     


Glu Gln Leu Ala Ala Leu Gln Ile Glu Tyr Glu Glu Asn Val Asp Leu 
            340                 345                 350         


Asn Asp Val Leu Val Pro Lys Pro Phe Ser Gln Phe Trp Gln Pro Leu 
        355                 360                 365             


Leu Arg Gly Leu His Ser Gln Asn Phe Thr Gln Ala Leu Leu Glu Arg 
    370                 375                 380                 


Met Leu Ser Glu Leu Pro Ala Leu Gly Ile Ser Gly Ile Arg Pro Thr 
385                 390                 395                 400 


Tyr Ile Leu Arg Trp Thr Val Glu Leu Ile Val Ala Asn Thr Lys Thr 
                405                 410                 415     


Gly Arg Asn Ala Arg Arg Phe Ser Ala Gly Gln Trp Glu Ala Arg Arg 
            420                 425                 430         


Gly Trp Arg Leu Phe Asn Cys Ser Ala Ser Leu Asp Trp Pro Arg Met 
        435                 440                 445             


Val Glu Ser Cys Leu Gly Ser Pro Cys Trp Ala Ser Pro Gln Leu Leu 
    450                 455                 460                 


Arg Ile Ile Phe Lys Ala Met Gly Gln Gly Leu Pro Asp Glu Glu Gln 
465                 470                 475                 480 


Glu Lys Leu Leu Arg Ile Cys Ser Ile Tyr Thr Gln Ser Gly Glu Asn 
                485                 490                 495     


Ser Leu Val Gln Glu Gly Ser Glu Ala Ser Pro Ile Gly Lys Ser Pro 
            500                 505                 510         


Tyr Thr Leu Asp Ser Leu Tyr Trp Ser Val Lys Pro Ala Ser Ser Ser 
        515                 520                 525             


Phe Gly Ser Glu Ala Lys Ala Gln Gln Gln Glu Glu Gln Gly Ser Val 
    530                 535                 540                 


Asn Asp Val Lys Glu Glu Glu Lys Glu Glu Lys Glu Val Leu Pro Asp 
545                 550                 555                 560 


Gln Val Glu Glu Glu Glu Glu Asn Asp Asp Gln Glu Glu Glu Glu Glu 
                565                 570                 575     


Asp Glu Asp Asp Glu Asp Asp Glu Glu Glu Asp Arg Met Glu Val Gly 
            580                 585                 590         


Pro Phe Ser Thr Gly Gln Glu Ser Pro Thr Ala Glu Asn Ala Arg Leu 
        595                 600                 605             


Leu Ala Gln Lys Arg Gly Ala Leu Gln Gly Ser Ala Trp Gln Val Ser 
    610                 615                 620                 


Ser Glu Asp Val Arg Trp Asp Thr Phe Pro Leu Gly Arg Met Pro Gly 
625                 630                 635                 640 


Gln Thr Glu Asp Pro Ala Glu Leu Met Leu Glu Asn Tyr Asp Thr Met 
                645                 650                 655     


Tyr Leu Leu Asp Gln Pro Val Leu Glu Gln Arg Leu Glu Pro Ser Thr 
            660                 665                 670         


Cys Lys Thr Asp Thr Leu Gly Leu Ser Cys Gly Val Gly Ser Gly Asn 
        675                 680                 685             


Cys Ser Asn Ser Ser Ser Ser Asn Phe Glu Gly Leu Leu Trp Ser Gln 
    690                 695                 700                 


Gly Gln Leu His Gly Leu Lys Thr Gly Leu Gln Leu Phe 
705                 710                 715         


<210>  6103
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LASP1__Homo_sapiens__NP_001258537

<400>  6103

Met Leu Pro Leu Arg Asp Leu Gln Asp Asp Thr Glu His Glu Glu Leu 
1               5                   10                  15      


Gln Gly Leu Arg Glu Glu Ala Leu Leu Gln Arg Val Arg Tyr Lys Glu 
            20                  25                  30          


Glu Phe Glu Lys Asn Lys Gly Lys Gly Phe Ser Val Val Ala Asp Thr 
        35                  40                  45              


Pro Glu Leu Gln Arg Ile Lys Lys Thr Gln Asp Gln Ile Ser Asn Ile 
    50                  55                  60                  


Lys Tyr His Glu Glu Phe Glu Lys Ser Arg Met Gly Pro Ser Gly Gly 
65                  70                  75                  80  


Glu Gly Met Glu Pro Glu Arg Arg Asp Ser Gln Asp Gly Ser Ser Tyr 
                85                  90                  95      


Arg Arg Pro Leu Glu Gln Gln Gln Pro His His Ile Pro Thr Ser Ala 
            100                 105                 110         


Pro Val Tyr Gln Gln Pro Gln Gln Gln Pro Val Ala Gln Ser Tyr Gly 
        115                 120                 125             


Gly Tyr Lys Glu Pro Ala Ala Pro Val Ser Ile Gln Arg Ser Ala Pro 
    130                 135                 140                 


Gly Gly Gly Gly Lys Arg Tyr Arg Ala Val Tyr Asp Tyr Ser Ala Ala 
145                 150                 155                 160 


Asp Glu Asp Glu Val Ser Phe Gln Asp Gly Asp Thr Ile Val Asn Val 
                165                 170                 175     


Gln Gln Ile Asp Asp Gly Trp Met Tyr Gly Thr Val Glu Arg Thr Gly 
            180                 185                 190         


Asp Thr Gly Met Leu Pro Ala Asn Tyr Val Glu Ala Ile 
        195                 200                 205 


<210>  6104
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAT2__Homo_sapiens__NP_115852

<400>  6104

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30          


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45              


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60                  


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95      


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110         


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125             


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140                 


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160 


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175     


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190         


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205             


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220                 


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240 


Thr Glu Ala 
            


<210>  6105
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAT__Homo_sapiens__NP_001014987

<400>  6105

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        115                 120                 125             


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    130                 135                 140                 


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala 
        195                 200                 205             


Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230             


<210>  6106
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LATS1__Homo_sapiens__NP_001257448

<400>  6106

Met Lys Arg Ser Glu Lys Pro Glu Gly Tyr Arg Gln Met Arg Pro Lys 
1               5                   10                  15      


Thr Phe Pro Ala Ser Asn Tyr Thr Val Ser Ser Arg Gln Met Leu Gln 
            20                  25                  30          


Glu Ile Arg Glu Ser Leu Arg Asn Leu Ser Lys Pro Ser Asp Ala Ala 
        35                  40                  45              


Lys Ala Glu His Asn Met Ser Lys Met Ser Thr Glu Asp Pro Arg Gln 
    50                  55                  60                  


Val Arg Asn Pro Pro Lys Phe Gly Thr His His Lys Ala Leu Gln Glu 
65                  70                  75                  80  


Ile Arg Asn Ser Leu Leu Pro Phe Ala Asn Glu Thr Asn Ser Ser Arg 
                85                  90                  95      


Ser Thr Ser Glu Val Asn Pro Gln Met Leu Gln Asp Leu Gln Ala Ala 
            100                 105                 110         


Gly Phe Asp Glu Asp Met Val Ile Gln Ala Leu Gln Lys Thr Asn Asn 
        115                 120                 125             


Arg Ser Ile Glu Ala Ala Ile Glu Phe Ile Ser Lys Met Ser Tyr Gln 
    130                 135                 140                 


Asp Pro Arg Arg Glu Gln Met Ala Ala Ala Ala Ala Arg Pro Ile Asn 
145                 150                 155                 160 


Ala Ser Met Lys Pro Gly Asn Val Gln Gln Ser Val Asn Arg Lys Gln 
                165                 170                 175     


Ser Trp Lys Gly Ser Lys Glu Ser Leu Val Pro Gln Arg His Gly Pro 
            180                 185                 190         


Pro Leu Gly Glu Ser Val Ala Tyr His Ser Glu Ser Pro Asn Ser Gln 
        195                 200                 205             


Thr Asp Val Gly Arg Pro Leu Ser Gly Ser Gly Ile Ser Ala Phe Val 
    210                 215                 220                 


Gln Ala His Pro Ser Asn Gly Gln Arg Val Asn Pro Pro Pro Pro Pro 
225                 230                 235                 240 


Gln Val Arg Ser Val Thr Pro Pro Pro Pro Pro Arg Gly Gln Thr Pro 
                245                 250                 255     


Pro Pro Arg Gly Thr Thr Pro Pro Pro Pro Ser Trp Glu Pro Asn Ser 
            260                 265                 270         


Gln Thr Lys Arg Tyr Ser Gly Asn Met Glu Tyr Val Ile Ser Arg Ile 
        275                 280                 285             


Ser Pro Val Pro Pro Gly Ala Trp Gln Glu Gly Tyr Pro Pro Pro Pro 
    290                 295                 300                 


Leu Asn Thr Ser Pro Met Asn Pro Pro Asn Gln Gly Gln Arg Gly Ile 
305                 310                 315                 320 


Ser Ser Val Pro Val Gly Arg Gln Pro Ile Ile Met Gln Ser Ser Ser 
                325                 330                 335     


Lys Phe Asn Phe Pro Ser Gly Arg Pro Gly Met Gln Asn Gly Thr Gly 
            340                 345                 350         


Gln Thr Asp Phe Met Ile His Gln Asn Val Val Pro Ala Gly Thr Val 
        355                 360                 365             


Asn Arg Gln Pro Pro Pro Pro Tyr Pro Leu Thr Ala Ala Asn Gly Gln 
    370                 375                 380                 


Ser Pro Ser Ala Leu Gln Thr Gly Gly Ser Ala Ala Pro Ser Ser Tyr 
385                 390                 395                 400 


Thr Asn Gly Ser Ile Pro Gln Ser Met Met Val Pro Asn Arg Asn Ser 
                405                 410                 415     


His Asn Met Glu Leu Tyr Asn Ile Ser Val Pro Gly Leu Gln Thr Asn 
            420                 425                 430         


Trp Pro Gln Ser Ser Ser Ala Pro Ala Gln Ser Ser Pro Ser Ser Gly 
        435                 440                 445             


His Glu Ile Pro Thr Trp Gln Pro Asn Ile Pro Val Arg Ser Asn Ser 
    450                 455                 460                 


Phe Asn Asn Pro Leu Gly Asn Arg Ala Ser His Ser Ala Asn Ser Gln 
465                 470                 475                 480 


Pro Ser Ala Thr Thr Val Thr Ala Ile Thr Pro Ala Pro Ile Gln Gln 
                485                 490                 495     


Pro Val Lys Ser Met Arg Val Leu Lys Pro Glu Leu Gln Thr Ala Leu 
            500                 505                 510         


Ala Pro Thr His Pro Ser Trp Ile Pro Gln Pro Ile Gln Thr Val Gln 
        515                 520                 525             


Pro Ser Pro Phe Pro Glu Gly Thr Ala Ser Asn Val Thr Val Met Pro 
    530                 535                 540                 


Pro Val Ala Glu Ala Pro Asn Tyr Gln Gly Pro Pro Pro Pro Tyr Pro 
545                 550                 555                 560 


Lys His Leu Leu His Gln Asn Pro Ser Val Pro Pro Tyr Glu Ser Ile 
                565                 570                 575     


Ser Lys Pro Ser Lys Glu Asp Gln Pro Ser Leu Pro Lys Glu Asp Glu 
            580                 585                 590         


Ser Glu Lys Ser Tyr Glu Asn Val Asp Ser Gly Asp Lys Glu Lys Lys 
        595                 600                 605             


Gln Ile Thr Thr Ser Pro Ile Thr Val Arg Lys Asn Lys Lys Asp Glu 
    610                 615                 620                 


Glu Arg Arg Glu Ser Arg Ile Gln Ser Tyr Ser Pro Gln Ala Phe Lys 
625                 630                 635                 640 


Phe Phe Met Glu Gln His Val Glu Asn Val Leu Lys Ser His Gln Gln 
                645                 650                 655     


Arg Leu His Arg Lys Lys Gln Leu Glu Asn Glu Met Met Arg Val Lys 
            660                 665                 670         


Pro Phe Lys Met Ser Ile Phe Ile Leu Asn His Leu Phe Ala Trp Cys 
        675                 680                 685             


Leu Phe 
    690 


<210>  6107
<211>  1088
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LATS2__Homo_sapiens__XP_005266399

<400>  6107

Met Arg Pro Lys Thr Phe Pro Ala Thr Thr Tyr Ser Gly Asn Ser Arg 
1               5                   10                  15      


Gln Arg Leu Gln Glu Ile Arg Glu Gly Leu Lys Gln Pro Ser Lys Ser 
            20                  25                  30          


Ser Val Gln Gly Leu Pro Ala Gly Pro Asn Ser Asp Thr Ser Leu Asp 
        35                  40                  45              


Ala Lys Val Leu Gly Ser Lys Asp Ala Thr Arg Gln Gln Gln Gln Met 
    50                  55                  60                  


Arg Ala Thr Pro Lys Phe Gly Pro Tyr Gln Lys Ala Leu Arg Glu Ile 
65                  70                  75                  80  


Arg Tyr Ser Leu Leu Pro Phe Ala Asn Glu Ser Gly Thr Ser Ala Ala 
                85                  90                  95      


Ala Glu Val Asn Arg Gln Met Leu Gln Glu Leu Val Asn Ala Gly Cys 
            100                 105                 110         


Asp Gln Glu Met Ala Gly Arg Ala Leu Lys Gln Thr Gly Ser Arg Ser 
        115                 120                 125             


Ile Glu Ala Ala Leu Glu Tyr Ile Ser Lys Met Gly Tyr Leu Asp Pro 
    130                 135                 140                 


Arg Asn Glu Gln Ile Val Arg Val Ile Lys Gln Thr Ser Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Met Pro Thr Pro Val Thr Arg Arg Pro Ser Phe Glu Gly Thr 
                165                 170                 175     


Gly Asp Ser Phe Ala Ser Tyr His Gln Leu Ser Gly Thr Pro Tyr Glu 
            180                 185                 190         


Gly Pro Ser Phe Gly Ala Asp Gly Pro Thr Ala Leu Glu Glu Met Pro 
        195                 200                 205             


Arg Pro Tyr Val Asp Tyr Leu Phe Pro Gly Val Gly Pro His Gly Pro 
    210                 215                 220                 


Gly His Gln His Gln His Pro Pro Lys Gly Tyr Gly Ala Ser Val Glu 
225                 230                 235                 240 


Ala Ala Gly Ala His Phe Pro Leu Gln Gly Ala His Tyr Gly Arg Pro 
                245                 250                 255     


His Leu Leu Val Pro Gly Glu Pro Leu Gly Tyr Gly Val Gln Arg Ser 
            260                 265                 270         


Pro Ser Phe Gln Ser Lys Thr Pro Pro Glu Thr Gly Gly Tyr Ala Ser 
        275                 280                 285             


Leu Pro Thr Lys Gly Gln Gly Gly Pro Pro Gly Ala Gly Leu Ala Phe 
    290                 295                 300                 


Pro Pro Pro Ala Ala Gly Leu Tyr Val Pro His Pro His His Lys Gln 
305                 310                 315                 320 


Ala Gly Pro Ala Ala His Gln Leu His Val Leu Gly Ser Arg Ser Gln 
                325                 330                 335     


Val Phe Ala Ser Asp Ser Pro Pro Gln Ser Leu Leu Thr Pro Ser Arg 
            340                 345                 350         


Asn Ser Leu Asn Val Asp Leu Tyr Glu Leu Gly Ser Thr Ser Val Gln 
        355                 360                 365             


Gln Trp Pro Ala Ala Thr Leu Ala Arg Arg Asp Ser Leu Gln Lys Pro 
    370                 375                 380                 


Gly Leu Glu Ala Pro Pro Arg Ala His Val Ala Phe Arg Pro Asp Cys 
385                 390                 395                 400 


Pro Val Pro Ser Arg Thr Asn Ser Phe Asn Ser His Gln Pro Arg Pro 
                405                 410                 415     


Gly Pro Pro Gly Lys Ala Glu Pro Ser Leu Pro Ala Pro Asn Thr Val 
            420                 425                 430         


Thr Ala Val Thr Ala Ala His Ile Leu His Pro Val Lys Ser Val Arg 
        435                 440                 445             


Val Leu Arg Pro Glu Pro Gln Thr Ala Val Gly Pro Ser His Pro Ala 
    450                 455                 460                 


Trp Val Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
465                 470                 475                 480 


Ala Glu Gly Leu Asp Ala Lys Glu Glu His Ala Leu Ala Leu Gly Gly 
                485                 490                 495     


Ala Gly Ala Phe Pro Leu Asp Val Glu Tyr Gly Gly Pro Asp Arg Arg 
            500                 505                 510         


Cys Pro Pro Pro Pro Tyr Pro Lys His Leu Leu Leu Arg Ser Lys Ser 
        515                 520                 525             


Glu Gln Tyr Asp Leu Asp Ser Leu Cys Ala Gly Met Glu Gln Ser Leu 
    530                 535                 540                 


Arg Ala Gly Pro Asn Glu Pro Glu Gly Gly Asp Lys Ser Arg Lys Ser 
545                 550                 555                 560 


Ala Lys Gly Asp Lys Gly Gly Lys Asp Lys Lys Gln Ile Gln Thr Ser 
                565                 570                 575     


Pro Val Pro Val Arg Lys Asn Ser Arg Asp Glu Glu Lys Arg Glu Ser 
            580                 585                 590         


Arg Ile Lys Ser Tyr Ser Pro Tyr Ala Phe Lys Phe Phe Met Glu Gln 
        595                 600                 605             


His Val Glu Asn Val Ile Lys Thr Tyr Gln Gln Lys Val Asn Arg Arg 
    610                 615                 620                 


Leu Gln Leu Glu Gln Glu Met Ala Lys Ala Gly Leu Cys Glu Ala Glu 
625                 630                 635                 640 


Gln Glu Gln Met Arg Lys Ile Leu Tyr Gln Lys Glu Ser Asn Tyr Asn 
                645                 650                 655     


Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met Phe Val Lys Ile Lys 
            660                 665                 670         


Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys Leu Ala Cys Lys Val 
        675                 680                 685             


Asp Thr His Ala Leu Tyr Ala Met Lys Thr Leu Arg Lys Lys Asp Val 
    690                 695                 700                 


Leu Asn Arg Asn Gln Val Ala His Val Lys Ala Glu Arg Asp Ile Leu 
705                 710                 715                 720 


Ala Glu Ala Asp Asn Glu Trp Val Val Lys Leu Tyr Tyr Ser Phe Gln 
                725                 730                 735     


Asp Lys Asp Ser Leu Tyr Phe Val Met Asp Tyr Ile Pro Gly Gly Asp 
            740                 745                 750         


Met Met Ser Leu Leu Ile Arg Met Glu Val Phe Pro Glu His Leu Ala 
        755                 760                 765             


Arg Phe Tyr Ile Ala Glu Leu Thr Leu Ala Ile Glu Ser Val His Lys 
    770                 775                 780                 


Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp Asn Ile Leu Ile Asp 
785                 790                 795                 800 


Leu Asp Gly His Ile Lys Leu Thr Asp Phe Gly Leu Cys Thr Gly Phe 
                805                 810                 815     


Arg Trp Thr His Asn Ser Lys Tyr Tyr Gln Lys Gly Ser His Val Arg 
            820                 825                 830         


Gln Asp Ser Met Glu Pro Ser Asp Leu Trp Asp Asp Val Ser Asn Cys 
        835                 840                 845             


Arg Cys Gly Asp Arg Leu Lys Thr Leu Glu Gln Arg Ala Arg Lys Gln 
    850                 855                 860                 


His Gln Arg Cys Leu Ala His Ser Leu Val Gly Thr Pro Asn Tyr Ile 
865                 870                 875                 880 


Ala Pro Glu Val Leu Leu Arg Lys Gly Tyr Thr Gln Leu Cys Asp Trp 
                885                 890                 895     


Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu Val Gly Gln Pro Pro 
            900                 905                 910         


Phe Leu Ala Pro Thr Pro Thr Glu Thr Gln Leu Lys Val Ile Asn Trp 
        915                 920                 925             


Glu Asn Thr Leu His Ile Pro Ala Gln Val Lys Leu Ser Pro Glu Ala 
    930                 935                 940                 


Arg Asp Leu Ile Thr Lys Leu Cys Cys Ser Ala Asp His Arg Leu Gly 
945                 950                 955                 960 


Arg Asn Gly Ala Asp Asp Leu Lys Ala His Pro Phe Phe Ser Ala Ile 
                965                 970                 975     


Asp Phe Ser Ser Asp Ile Arg Lys Gln Pro Ala Pro Tyr Val Pro Thr 
            980                 985                 990         


Ile Ser His Pro Met Asp Thr Ser  Asn Phe Asp Pro Val  Asp Glu Glu 
        995                 1000                 1005             


Ser Pro  Trp Asn Asp Ala Ser  Glu Gly Ser Thr Lys  Ala Trp Asp 
    1010                 1015                 1020             


Thr Leu  Thr Ser Pro Asn Asn  Lys His Pro Glu His  Ala Phe Tyr 
    1025                 1030                 1035             


Glu Phe  Thr Phe Arg Arg Phe  Phe Asp Asp Asn Gly  Tyr Pro Phe 
    1040                 1045                 1050             


Arg Cys  Pro Lys Pro Ser Gly  Ala Glu Ala Ser Gln  Ala Glu Ser 
    1055                 1060                 1065             


Ser Asp  Leu Glu Ser Ser Asp  Leu Val Asp Gln Thr  Glu Gly Cys 
    1070                 1075                 1080             


Gln Pro  Val Tyr Val 
    1085             


<210>  6108
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAX1__Homo_sapiens__NP_001129662

<400>  6108

Met Arg Ser His Phe Leu Gln Trp Ala Leu Ala Thr Ser Arg Asn Lys 
1               5                   10                  15      


Asp Gln Ile Thr Asn Ile Phe Ser Gly Phe Ala Gly Leu Leu Ala Ile 
            20                  25                  30          


Leu Leu Val Val Ala Val Phe Cys Ile Leu Trp Asn Trp Asn Lys Arg 
        35                  40                  45              


Lys Lys Arg Gln Val Pro Tyr Leu Arg Val Thr Val Met Pro Leu Leu 
    50                  55                  60                  


Thr Leu Pro Gln Thr Arg Gln Arg Ala Lys Asn Ile Tyr Asp Ile Leu 
65                  70                  75                  80  


Pro Trp Arg Gln Glu Asp Leu Gly Arg His Glu Ser Arg Ser Met Arg 
                85                  90                  95      


Ile Phe Ser Thr Glu Ser Leu Leu Ser Arg Asn Ser Glu Ser Pro Glu 
            100                 105                 110         


His Val Pro Ser Gln Ala Gly Asn Ala Phe Gln Glu His Thr Ala His 
        115                 120                 125             


Ile His Ala Thr Glu Tyr Ala Val Gly Ile Tyr Asp Asn Ala Met Val 
    130                 135                 140                 


Pro Gln Met Cys Gly Asn Leu Thr Pro Ser Ala His Cys Ile Asn Val 
145                 150                 155                 160 


Arg Ala Ser Arg Asp Cys Ala Ser Ile Ser Ser Glu Asp Ser His Asp 
                165                 170                 175     


Tyr Val Asn Val Pro Thr Ala Glu Glu Ile Ala Glu Thr Leu Ala Ser 
            180                 185                 190         


Thr Lys Ser Pro Ser Arg Asn Leu Phe Val Leu Pro Ser Thr Gln Lys 
        195                 200                 205             


Leu Glu Phe Thr Glu Glu Arg Asp Glu Gly Cys Gly Asp Ala Gly Asp 
    210                 215                 220                 


Cys Thr Ser Leu Tyr Ser Pro Gly Ala Glu Asp Ser Asp Ser Leu Ser 
225                 230                 235                 240 


Asn Gly Glu Gly Ser Ser Gln Ile Ser Asn Asp Tyr Val Asn Met Thr 
                245                 250                 255     


Gly Leu Asp Leu Ser Ala Ile Gln Glu Arg Gln Leu Trp Val Ala Phe 
            260                 265                 270         


Gln Cys Cys Arg Asp Tyr Glu Asn Val Pro Ala Ala Asp Pro Ser Gly 
        275                 280                 285             


Ser Gln Gln Gln Ala Glu Lys Asp Val Pro Ser Ser Asn Ile Gly His 
    290                 295                 300                 


Val Glu Asp Lys Thr Asp Asp Pro Gly Thr His Val Gln Cys Val Lys 
305                 310                 315                 320 


Arg Thr Phe Leu Ala Ser Gly Asp Tyr Ala Asp Phe Gln Pro Phe Thr 
                325                 330                 335     


Gln Ser Glu Asp Ser Gln Met Lys His Arg Glu Glu Met Ser Asn Glu 
            340                 345                 350         


Asp Ser Ser Asp Tyr Glu Asn Val Leu Thr Ala Lys Leu Gly Gly Arg 
        355                 360                 365             


Asp Ser Glu Gln Gly Pro Gly Thr Gln Leu Leu Pro Asp Glu 
    370                 375                 380         


<210>  6109
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAYN__Homo_sapiens__NP_001245319

<400>  6109

Met Arg Pro Gly Thr Ala Leu Gln Ala Val Leu Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Gly Leu Arg Ala Ala Thr Gly Arg Leu Leu Ser Ala Ser Asp Leu 
            20                  25                  30          


Asp Leu Arg Gly Gly Gln Pro Val Cys Arg Gly Gly Thr Gln Arg Pro 
        35                  40                  45              


Cys Tyr Lys Val Ile Tyr Phe His Asp Thr Ser Arg Arg Leu Asn Phe 
    50                  55                  60                  


Glu Glu Ala Lys Glu Ala Cys Arg Arg Asp Gly Gly Gln Leu Val Ser 
65                  70                  75                  80  


Ile Glu Ser Glu Asp Glu Gln Lys Leu Ile Glu Lys Phe Ile Glu Asn 
                85                  90                  95      


Leu Leu Pro Ser Asp Gly Asp Phe Trp Ile Gly Leu Arg Arg Arg Glu 
            100                 105                 110         


Glu Lys Gln Ser Asn Ser Thr Ala Cys Gln Asp Leu Tyr Ala Trp Thr 
        115                 120                 125             


Asp Gly Ser Ile Ser Gln Phe Arg Asn Trp Tyr Val Asp Glu Pro Ser 
    130                 135                 140                 


Cys Gly Ser Glu Val Cys Val Val Met Tyr His Gln Pro Ser Ala Pro 
145                 150                 155                 160 


Ala Gly Ile Gly Gly Pro Tyr Met Phe Gln Trp Asn Asp Asp Arg Cys 
                165                 170                 175     


Asn Met Lys Asn Asn Phe Ile Cys Lys Tyr Ser Asp Glu Lys Pro Ala 
            180                 185                 190         


Val Pro Ser Arg Glu Ala Glu Gly Glu Glu Thr Glu Leu Thr Thr Pro 
        195                 200                 205             


Val Leu Pro Glu Glu Thr Gln Glu Glu Asp Ala Lys Lys Thr Phe Lys 
    210                 215                 220                 


Glu Ser Arg Glu Ala Ala Leu Asn Leu Ala Tyr Ile Leu Ile Pro Ser 
225                 230                 235                 240 


Ile Pro Leu Leu Leu Leu Leu Val Val Thr Thr Val Val Cys Trp Val 
                245                 250                 255     


Trp Ile Cys Arg Lys Arg Lys Arg Glu Gln Pro Asp Pro Ser Thr Lys 
            260                 265                 270         


Lys Gln His Thr Ile Trp Pro Ser Pro His Gln Gly Asn Ser Pro Asp 
        275                 280                 285             


Leu Glu Val Tyr Asn Val Ile Arg Lys Gln Ser Glu Ala Asp Leu Ala 
    290                 295                 300                 


Glu Thr Arg Pro Asp Leu Lys Asn Ile Ser Phe Arg Val Cys Ser Gly 
305                 310                 315                 320 


Glu Ala Thr Pro Asp Asp Met Ser Cys Asp Tyr Asp Asn Met Ala Val 
                325                 330                 335     


Asn Pro Ser Glu Ser Gly Phe Val Thr Leu Val Ser Val Glu Ser Gly 
            340                 345                 350         


Phe Val Thr Asn Asp Ile Tyr Glu Phe Ser Pro Asp Gln Met Gly Arg 
        355                 360                 365             


Ser Lys Glu Ser Gly Trp Val Glu Asn Glu Ile Tyr Gly Tyr 
    370                 375                 380         


<210>  6110
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LBH__Homo_sapiens__NP_112177

<400>  6110

Met Ser Ile Tyr Phe Pro Ile His Cys Pro Asp Tyr Leu Arg Ser Ala 
1               5                   10                  15      


Lys Met Thr Glu Val Met Met Asn Thr Gln Pro Met Glu Glu Ile Gly 
            20                  25                  30          


Leu Ser Pro Arg Lys Asp Gly Leu Ser Tyr Gln Ile Phe Pro Asp Pro 
        35                  40                  45              


Ser Asp Phe Asp Arg Cys Cys Lys Leu Lys Asp Arg Leu Pro Ser Ile 
    50                  55                  60                  


Val Val Glu Pro Thr Glu Gly Glu Val Glu Ser Gly Glu Leu Arg Trp 
65                  70                  75                  80  


Pro Pro Glu Glu Phe Leu Val Gln Glu Asp Glu Gln Asp Asn Cys Glu 
                85                  90                  95      


Glu Thr Ala Lys Glu Asn Lys Glu Gln 
            100                 105 


<210>  6111
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LBP__Homo_sapiens__NP_004130

<400>  6111

Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala 
            20                  25                  30          


Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu 
        35                  40                  45              


Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly 
    50                  55                  60                  


Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser 
65                  70                  75                  80  


Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val 
                85                  90                  95      


Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val 
            100                 105                 110         


Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser 
        115                 120                 125             


Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu 
    130                 135                 140                 


Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser 
145                 150                 155                 160 


Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp 
                165                 170                 175     


Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val 
            180                 185                 190         


Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp 
        195                 200                 205             


Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser 
    210                 215                 220                 


Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala 
225                 230                 235                 240 


Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His 
                245                 250                 255     


Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu 
            260                 265                 270         


His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr 
        275                 280                 285             


Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr 
    290                 295                 300                 


Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser 
305                 310                 315                 320 


Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn 
                325                 330                 335     


Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser 
            340                 345                 350         


Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val 
        355                 360                 365             


Leu Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala 
    370                 375                 380                 


Thr Asn Val Ser Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Lys Pro Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val 
                405                 410                 415     


Gly Leu Phe Asn Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile 
            420                 425                 430         


Leu Asn Thr Phe Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe 
        435                 440                 445             


Pro Leu Pro Leu Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln 
    450                 455                 460                 


Ile His Lys Asp Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg 
465                 470                 475                 480 


Val 
    


<210>  6112
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LBR__Homo_sapiens__XP_005273182

<400>  6112

Met Pro Ser Arg Lys Phe Ala Asp Gly Glu Val Val Arg Gly Arg Trp 
1               5                   10                  15      


Pro Gly Ser Ser Leu Tyr Tyr Glu Val Glu Ile Leu Ser His Asp Ser 
            20                  25                  30          


Thr Ser Gln Leu Tyr Thr Val Lys Tyr Lys Asp Gly Thr Glu Leu Glu 
        35                  40                  45              


Leu Lys Glu Asn Asp Ile Lys Pro Leu Thr Ser Phe Arg Gln Arg Lys 
    50                  55                  60                  


Gly Gly Ser Thr Ser Ser Ser Pro Ser Arg Arg Arg Gly Ser Arg Ser 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Pro Gly Arg Pro Pro Lys Ser Ala Arg Arg 
                85                  90                  95      


Ser Ala Ser Ala Ser His Gln Ala Asp Ile Lys Glu Ala Arg Arg Glu 
            100                 105                 110         


Val Glu Val Lys Leu Thr Pro Leu Ile Leu Lys Pro Phe Gly Asn Ser 
        115                 120                 125             


Ile Ser Arg Tyr Asn Gly Glu Pro Glu His Ile Glu Arg Asn Asp Ala 
    130                 135                 140                 


Pro His Lys Asn Thr Gln Glu Lys Phe Ser Leu Ser Gln Glu Ser Ser 
145                 150                 155                 160 


Tyr Ile Ala Thr Gln Tyr Ser Leu Arg Pro Arg Arg Glu Glu Val Lys 
                165                 170                 175     


Leu Lys Glu Ile Asp Ser Lys Glu Glu Lys Tyr Val Ala Lys Glu Leu 
            180                 185                 190         


Ala Val Arg Thr Phe Glu Val Thr Pro Ile Arg Ala Lys Asp Leu Glu 
        195                 200                 205             


Phe Gly Gly Val Pro Gly Val Phe Leu Ile Met Phe Gly Leu Pro Val 
    210                 215                 220                 


Phe Leu Phe Leu Leu Leu Leu Met Cys Lys Gln Lys Asp Pro Ser Leu 
225                 230                 235                 240 


Leu Asn Phe Pro Pro Pro Leu Pro Ala Leu Tyr Glu Leu Trp Glu Thr 
                245                 250                 255     


Arg Val Phe Gly Val Tyr Leu Leu Trp Phe Leu Ile Gln Val Leu Phe 
            260                 265                 270         


Tyr Leu Leu Pro Ile Gly Lys Val Val Glu Gly Thr Pro Leu Ile Asp 
        275                 280                 285             


Gly Arg Arg Leu Lys Tyr Arg Leu Asn Gly Phe Tyr Ala Phe Ile Leu 
    290                 295                 300                 


Thr Ser Ala Val Ile Gly Thr Ser Leu Phe Gln Gly Val Glu Phe His 
305                 310                 315                 320 


Tyr Val Tyr Ser His Phe Leu Gln Phe Ala Leu Ala Ala Thr Val Phe 
                325                 330                 335     


Cys Val Val Leu Ser Val Tyr Leu Tyr Met Arg Ser Leu Lys Ala Pro 
            340                 345                 350         


Arg Asn Asp Leu Ser Pro Ala Ser Ser Gly Asn Ala Val Tyr Asp Phe 
        355                 360                 365             


Phe Ile Gly Arg Glu Leu Asn Pro Arg Ile Gly Thr Phe Asp Leu Lys 
    370                 375                 380                 


Tyr Phe Cys Glu Leu Arg Pro Gly Leu Ile Gly Trp Glu Ala Leu Leu 
385                 390                 395                 400 


Thr Thr Met Asp Ile Ile His Asp Gly Phe Gly Phe Met Leu Ala Phe 
                405                 410                 415     


Gly Asp Leu Val Trp Val Pro Phe Ile Tyr Ser Phe Gln Ala Phe Tyr 
            420                 425                 430         


Leu Val Ser His Pro Asn Glu Val Ser Trp Pro Met Ala Ser Leu Ile 
        435                 440                 445             


Ile Val Leu Lys Leu Cys Gly Tyr Val Ile Phe Arg Gly Ala Asn Ser 
    450                 455                 460                 


Gln Lys Asn Ala Phe Arg Lys Asn Pro Ser Asp Pro Lys Leu Ala His 
465                 470                 475                 480 


Leu Lys Thr Ile His Thr Ser Thr Gly Lys Asn Leu Leu Val Ser Gly 
                485                 490                 495     


Trp Trp Gly Phe Val Arg His Pro Asn Tyr Leu Gly Asp Leu Ile Met 
            500                 505                 510         


Ala Leu Ala Trp Ser Leu Pro Cys Gly Phe Asn His Ile Leu Pro Tyr 
        515                 520                 525             


Phe Tyr Ile Ile Tyr Phe Thr Met Leu Leu Val His Arg Glu Ala Arg 
    530                 535                 540                 


Asp Glu Tyr His Cys Lys Lys Lys Tyr Gly Val Ala Trp Glu Lys Tyr 
545                 550                 555                 560 


Cys Gln Arg Val Pro Tyr Arg Ile Phe Pro Tyr Ile Tyr 
                565                 570             


<210>  6113
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LBX1__Homo_sapiens__XP_005269500

<400>  6113

Met Thr Ser Lys Glu Asp Gly Lys Ala Ala Pro Gly Glu Glu Arg Arg 
1               5                   10                  15      


Arg Ser Pro Leu Asp His Leu Pro Pro Pro Ala Asn Ser Asn Lys Pro 
            20                  25                  30          


Leu Thr Pro Phe Ser Ile Glu Asp Ile Leu Asn Lys Pro Ser Val Arg 
        35                  40                  45              


Arg Ser Tyr Ser Leu Cys Gly Ala Ala His Leu Leu Ala Ala Ala Asp 
    50                  55                  60                  


Lys His Ala Gln Gly Gly Leu Pro Leu Ala Gly Arg Ala Leu Leu Ser 
65                  70                  75                  80  


Gln Thr Ser Pro Leu Cys Ala Leu Glu Glu Leu Ala Ser Lys Thr Phe 
                85                  90                  95      


Lys Gly Leu Glu Val Ser Val Leu Gln Ala Ala Glu Gly Arg Asp Gly 
            100                 105                 110         


Met Thr Ile Phe Gly Gln Arg Gln Thr Pro Lys Lys Arg Arg Lys Ser 
        115                 120                 125             


Arg Thr Ala Phe Thr Asn His Gln Ile Tyr Glu Leu Glu Lys Arg Phe 
    130                 135                 140                 


Leu Tyr Gln Lys Tyr Leu Ser Pro Ala Asp Arg Asp Gln Ile Ala Gln 
145                 150                 155                 160 


Gln Leu Gly Leu Thr Asn Ala Gln Val Ile Thr Trp Phe Gln Asn Arg 
                165                 170                 175     


Arg Ala Lys Leu Lys Arg Asp Leu Glu Glu Met Lys Ala Asp Val Glu 
            180                 185                 190         


Ser Ala Lys Lys Leu Gly Pro Ser Gly Gln Met Asp Ile Val Ala Leu 
        195                 200                 205             


Ala Glu Leu Glu Gln Asn Ser Glu Ala Thr Ala Gly Gly Gly Gly Gly 
    210                 215                 220                 


Cys Gly Arg Ala Lys Ser Arg Pro Gly Ser Pro Val Leu Pro Pro Gly 
225                 230                 235                 240 


Ala Pro Lys Ala Pro Gly Ala Gly Ala Leu Gln Leu Ser Pro Ala Ser 
                245                 250                 255     


Pro Leu Thr Asp Gln Pro Ala Ser Ser Gln Asp Cys Ser Glu Asp Glu 
            260                 265                 270         


Glu Asp Glu Glu Ile Asp Val Asp Asp 
        275                 280     


<210>  6114
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LBX2__Homo_sapiens__NP_001009812

<400>  6114

Met Gly Lys Arg Thr Ser Leu Glu Val Ser Leu Gly Glu Leu Gly Gly 
1               5                   10                  15      


Glu Lys Cys Arg Gly Gly Arg Arg Ser Phe Pro Pro Leu Ala Ala Ser 
            20                  25                  30          


Arg Pro Ala Arg Pro Gly Gly Trp Arg Trp Ala Arg Arg Asp Leu Cys 
        35                  40                  45              


Lys Thr Ala Ser Arg Ala Glu Asn Asn Ser Gln Ala Cys Arg Pro Gln 
    50                  55                  60                  


Arg Arg Ala Gly Pro Asp Ala Leu Gly Pro Gly Pro Phe Gly Arg Lys 
65                  70                  75                  80  


Arg Arg Lys Ser Arg Thr Ala Phe Thr Ala Gln Gln Val Leu Glu Leu 
                85                  90                  95      


Glu Arg Arg Phe Val Phe Gln Lys Tyr Leu Ala Pro Ser Glu Arg Asp 
            100                 105                 110         


Gly Leu Ala Thr Arg Leu Gly Leu Ala Asn Ala Gln Val Val Thr Trp 
        115                 120                 125             


Phe Gln Asn Arg Arg Ala Lys Leu Lys Arg Asp Val Glu Glu Met Arg 
    130                 135                 140                 


Ala Asp Val Ala Ser Leu Arg Ala Leu Ser Pro Glu Val Leu Cys Ser 
145                 150                 155                 160 


Leu Ala Leu Pro Glu Gly Ala Pro Asp Pro Gly Leu Cys Leu Gly Pro 
                165                 170                 175     


Ala Gly Pro Asp Ser Arg Pro His Leu Ser Asp Glu Glu Ile Gln Val 
            180                 185                 190         


Asp Asp 
        


<210>  6115
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCA5__Homo_sapiens__NP_001116241

<400>  6115

Met Gly Glu Arg Ala Gly Ser Pro Gly Thr Asp Gln Glu Arg Lys Ala 
1               5                   10                  15      


Gly Lys His His Tyr Ser Tyr Leu Ser Asp Phe Glu Thr Pro Gln Ser 
            20                  25                  30          


Ser Gly Arg Ser Ser Leu Val Ser Ser Ser Pro Ala Ser Val Arg Arg 
        35                  40                  45              


Lys Asn Pro Lys Arg Gln Thr Ser Asp Gly Gln Val His His Gln Ala 
    50                  55                  60                  


Pro Arg Lys Pro Ser Pro Lys Gly Leu Pro Asn Arg Lys Gly Val Arg 
65                  70                  75                  80  


Val Gly Phe Arg Ser Gln Ser Leu Asn Arg Glu Pro Leu Arg Lys Asp 
                85                  90                  95      


Thr Asp Leu Val Thr Lys Arg Ile Leu Ser Ala Arg Leu Leu Lys Ile 
            100                 105                 110         


Asn Glu Leu Gln Asn Glu Val Ser Glu Leu Gln Val Lys Leu Ala Glu 
        115                 120                 125             


Leu Leu Lys Glu Asn Lys Ser Leu Lys Arg Leu Gln Tyr Arg Gln Glu 
    130                 135                 140                 


Lys Ala Leu Asn Lys Phe Glu Asp Ala Glu Asn Glu Ile Ser Gln Leu 
145                 150                 155                 160 


Ile Phe Arg His Asn Asn Glu Ile Thr Ala Leu Lys Glu Arg Leu Arg 
                165                 170                 175     


Lys Ser Gln Glu Lys Glu Arg Ala Thr Glu Lys Arg Val Lys Asp Thr 
            180                 185                 190         


Glu Ser Glu Leu Phe Arg Thr Lys Phe Ser Leu Gln Lys Leu Lys Glu 
        195                 200                 205             


Ile Ser Glu Ala Arg His Leu Pro Glu Arg Asp Asp Leu Ala Lys Lys 
    210                 215                 220                 


Leu Val Ser Ala Glu Leu Lys Leu Asp Asp Thr Glu Arg Arg Ile Lys 
225                 230                 235                 240 


Glu Leu Ser Lys Asn Leu Glu Leu Ser Thr Asn Ser Phe Gln Arg Gln 
                245                 250                 255     


Leu Leu Ala Glu Arg Lys Arg Ala Tyr Glu Ala His Asp Glu Asn Lys 
            260                 265                 270         


Val Leu Gln Lys Glu Val Gln Arg Leu Tyr His Lys Leu Lys Glu Lys 
        275                 280                 285             


Glu Arg Glu Leu Asp Ile Lys Asn Ile Tyr Ser Asn Arg Leu Pro Lys 
    290                 295                 300                 


Ser Ser Pro Asn Lys Glu Lys Glu Leu Ala Leu Arg Lys Asn Ala Ala 
305                 310                 315                 320 


Cys Gln Ser Asp Phe Ala Asp Leu Cys Thr Lys Gly Val Gln Thr Met 
                325                 330                 335     


Glu Asp Phe Lys Pro Glu Glu Tyr Pro Leu Thr Pro Glu Thr Ile Met 
            340                 345                 350         


Cys Tyr Glu Asn Lys Trp Glu Glu Pro Gly His Leu Thr Leu Asp Leu 
        355                 360                 365             


Gln Ser Gln Lys Gln Asp Arg His Gly Glu Ala Gly Ile Leu Asn Pro 
    370                 375                 380                 


Ile Met Glu Arg Glu Glu Lys Phe Val Thr Asp Glu Glu Leu His Val 
385                 390                 395                 400 


Val Lys Gln Glu Val Glu Lys Leu Glu Asp Glu Trp Glu Arg Glu Glu 
                405                 410                 415     


Leu Asp Lys Lys Gln Lys Glu Lys Ala Ser Leu Leu Glu Arg Glu Glu 
            420                 425                 430         


Lys Pro Glu Trp Glu Thr Gly Arg Tyr Gln Leu Gly Met Tyr Pro Ile 
        435                 440                 445             


Gln Asn Met Asp Lys Leu Gln Gly Glu Glu Glu Glu Arg Leu Lys Arg 
    450                 455                 460                 


Glu Met Leu Leu Ala Lys Leu Asn Glu Ile Asp Arg Glu Leu Gln Asp 
465                 470                 475                 480 


Ser Arg Asn Leu Lys Tyr Pro Val Leu Pro Leu Leu Pro Asp Phe Glu 
                485                 490                 495     


Ser Lys Leu His Ser Pro Glu Arg Ser Pro Lys Thr Tyr Arg Phe Ser 
            500                 505                 510         


Glu Ser Ser Glu Arg Leu Phe Asn Gly His His Leu Gln Asp Ile Ser 
        515                 520                 525             


Phe Ser Thr Pro Lys Gly Glu Gly Gln Asn Ser Gly Asn Val Arg Ser 
    530                 535                 540                 


Pro Ala Ser Pro Asn Glu Phe Ala Phe Gly Ser Tyr Val Pro Ser Phe 
545                 550                 555                 560 


Ala Lys Thr Ser Glu Arg Ser Asn Pro Phe Ser Gln Lys Ser Ser Phe 
                565                 570                 575     


Leu Asp Phe Gln Arg Asn Ser Met Glu Lys Leu Ser Lys Asp Gly Val 
            580                 585                 590         


Asp Leu Ile Thr Arg Lys Glu Lys Lys Ala Asn Leu Met Glu Gln Leu 
        595                 600                 605             


Phe Gly Ala Ser Gly Ser Ser Thr Ile Ser Ser Lys Ser Ser Asp Pro 
    610                 615                 620                 


Asn Ser Val Ala Ser Ser Lys Gly Asp Ile Asp Pro Leu Asn Phe Leu 
625                 630                 635                 640 


Pro Gly Asn Lys Gly Ser Arg Asp Gln Glu His Asp Glu Asp Glu Gly 
                645                 650                 655     


Phe Phe Leu Ser Glu Gly Arg Ser Phe Asn Pro Asn Arg His Arg Leu 
            660                 665                 670         


Lys His Ala Asp Asp Lys Pro Ala Val Lys Ala Ala Asp Ser Val Glu 
        675                 680                 685             


Asp Glu Ile Glu Glu Val Ala Leu Arg 
    690                 695         


<210>  6116
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCAT__Homo_sapiens__NP_000220

<400>  6116

Met Gly Pro Pro Gly Ser Pro Trp Gln Trp Val Thr Leu Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Pro Pro Ala Ala Pro Phe Trp Leu Leu Asn Val Leu Phe 
            20                  25                  30          


Pro Pro His Thr Thr Pro Lys Ala Glu Leu Ser Asn His Thr Arg Pro 
        35                  40                  45              


Val Ile Leu Val Pro Gly Cys Leu Gly Asn Gln Leu Glu Ala Lys Leu 
    50                  55                  60                  


Asp Lys Pro Asp Val Val Asn Trp Met Cys Tyr Arg Lys Thr Glu Asp 
65                  70                  75                  80  


Phe Phe Thr Ile Trp Leu Asp Leu Asn Met Phe Leu Pro Leu Gly Val 
                85                  90                  95      


Asp Cys Trp Ile Asp Asn Thr Arg Val Val Tyr Asn Arg Ser Ser Gly 
            100                 105                 110         


Leu Val Ser Asn Ala Pro Gly Val Gln Ile Arg Val Pro Gly Phe Gly 
        115                 120                 125             


Lys Thr Tyr Ser Val Glu Tyr Leu Asp Ser Ser Lys Leu Ala Gly Tyr 
    130                 135                 140                 


Leu His Thr Leu Val Gln Asn Leu Val Asn Asn Gly Tyr Val Arg Asp 
145                 150                 155                 160 


Glu Thr Val Arg Ala Ala Pro Tyr Asp Trp Arg Leu Glu Pro Gly Gln 
                165                 170                 175     


Gln Glu Glu Tyr Tyr Arg Lys Leu Ala Gly Leu Val Glu Glu Met His 
            180                 185                 190         


Ala Ala Tyr Gly Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys 
        195                 200                 205             


Leu His Leu Leu Tyr Phe Leu Leu Arg Gln Pro Gln Ala Trp Lys Asp 
    210                 215                 220                 


Arg Phe Ile Asp Gly Phe Ile Ser Leu Gly Ala Pro Trp Gly Gly Ser 
225                 230                 235                 240 


Ile Lys Pro Met Leu Val Leu Ala Ser Gly Asp Asn Gln Gly Ile Pro 
                245                 250                 255     


Ile Met Ser Ser Ile Lys Leu Lys Glu Glu Gln Arg Ile Thr Thr Thr 
            260                 265                 270         


Ser Pro Trp Met Phe Pro Ser Arg Met Ala Trp Pro Glu Asp His Val 
        275                 280                 285             


Phe Ile Ser Thr Pro Ser Phe Asn Tyr Thr Gly Arg Asp Phe Gln Arg 
    290                 295                 300                 


Phe Phe Ala Asp Leu His Phe Glu Glu Gly Trp Tyr Met Trp Leu Gln 
305                 310                 315                 320 


Ser Arg Asp Leu Leu Ala Gly Leu Pro Ala Pro Gly Val Glu Val Tyr 
                325                 330                 335     


Cys Leu Tyr Gly Val Gly Leu Pro Thr Pro Arg Thr Tyr Ile Tyr Asp 
            340                 345                 350         


His Gly Phe Pro Tyr Thr Asp Pro Val Gly Val Leu Tyr Glu Asp Gly 
        355                 360                 365             


Asp Asp Thr Val Ala Thr Arg Ser Thr Glu Leu Cys Gly Leu Trp Gln 
    370                 375                 380                 


Gly Arg Gln Pro Gln Pro Val His Leu Leu Pro Leu His Gly Ile Gln 
385                 390                 395                 400 


His Leu Asn Met Val Phe Ser Asn Leu Thr Leu Glu His Ile Asn Ala 
                405                 410                 415     


Ile Leu Leu Gly Ala Tyr Arg Gln Gly Pro Pro Ala Ser Pro Thr Ala 
            420                 425                 430         


Ser Pro Glu Pro Pro Pro Pro Glu 
        435                 440 


<210>  6117
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCE1C__Homo_sapiens__NP_001263260

<400>  6117

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Asn Val 
1               5                   10                  15      


Ser Ser Gly Gly Cys Cys Gly Ser Ser Ser Gly Gly Ser Cys Gly Ser 
            20                  25                  30          


Ser Ser Gly Gly Cys Cys Ser Ser Gly Gly Gly Gly Cys Cys Leu Ser 
        35                  40                  45              


His His Arg Arg Arg Arg Ser His Cys His Arg Pro Gln Ser Ser Gly 
    50                  55                  60                  


Cys Cys Ser Gln Pro Ser Gly Gly Ser Ser Cys Cys Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gln His Ser Gly Gly Cys Cys 
                85              


<210>  6118
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCE3A__Homo_sapiens__NP_848518

<400>  6118

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ala Lys Ser Pro Ala Gln Cys Leu Pro Pro Ala Ser Ser Ser Cys 
            20                  25                  30          


Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser Glu Arg Ser Cys Cys 
        35                  40                  45              


Leu Ser His His Arg Cys Arg Arg Ser His Arg Cys Arg Cys Gln Ser 
    50                  55                  60                  


Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly Ser Ser Ser 
65                  70                  75                  80  


Cys Gly His Ser Ser Ala Gly Cys Cys 
                85                  


<210>  6119
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCE3B__Homo_sapiens__NP_848520

<400>  6119

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Leu Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Ser Ala Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Cys Cys Ala Pro Arg Pro Gly Cys Cys Gly Gly Pro Ser 
        35                  40                  45              


Ser Glu Gly Gly Cys Cys Leu Ser His His Arg Cys Cys Arg Ser His 
    50                  55                  60                  


Arg Cys Arg Arg Gln Ser Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln 
65                  70                  75                  80  


Gln Asp Gly Ala Ser Asp Cys Gly Tyr Gly Ser Gly Gly Cys Cys 
                85                  90                  95  


<210>  6120
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCE3C__Homo_sapiens__NP_848521

<400>  6120

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Ser Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Pro Ala Gln Cys Leu Pro Pro 
            20                  25                  30          


Pro Ser Ser Asp Cys Ala Leu Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Ser Gly Cys Cys Leu Ser His His Arg His Phe Arg Ser His Gln 
    50                  55                  60                  


Cys Arg Arg Gln Arg Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln 
65                  70                  75                  80  


Gly Gly Gly Ser Cys Arg Gly His Gly Ser Gly Gly Cys Cys 
                85                  90                  


<210>  6121
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCE3D__Homo_sapiens__NP_115952

<400>  6121

Met Ser Cys Gln Gln Asn Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Ser Pro Val Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Gly Cys Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Gly Gly Cys Phe Leu Asn His His Arg Arg His His Arg Cys Arg 
    50                  55                  60                  


Arg Gln Arg Pro Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Cys Gly His Gly Ser Gly Gly Cys Cys 
                85                  90          


<210>  6122
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCE3E__Homo_sapiens__NP_848522

<400>  6122

Met Ser Cys Gln Gln Asn Gln Lys Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Pro Ser Pro Lys Cys Pro Pro Lys Asn Pro Val Gln Cys Leu Pro Pro 
            20                  25                  30          


Ala Ser Ser Gly Cys Ala Pro Ser Ser Gly Gly Cys Gly Pro Ser Ser 
        35                  40                  45              


Glu Gly Gly Cys Phe Leu Asn His His Arg Arg His His Arg Cys Arg 
    50                  55                  60                  


Arg Gln Arg Ser Asn Ser Cys Asp Arg Gly Ser Gly Gln Gln Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Cys Cys His Gly Ser Gly Gly Cys Cys 
                85                  90          


<210>  6123
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCE5A__Homo_sapiens__NP_848525

<400>  6123

Met Ser Cys Gln Gln Ser Gln Gln Gln Cys Gln Pro Pro Pro Lys Cys 
1               5                   10                  15      


Thr Pro Lys Cys Pro Pro Lys Cys Thr Pro Lys Cys Pro Pro Lys Cys 
            20                  25                  30          


Pro Pro Lys Cys Pro Pro Gln Cys Ser Ala Pro Cys Pro Pro Pro Val 
        35                  40                  45              


Ser Ser Cys Cys Gly Ser Ser Ser Gly Gly Cys Cys Ser Ser Glu Gly 
    50                  55                  60                  


Gly Gly Cys Cys Leu Ser His His Arg Pro Arg Gln Ser Leu Arg Arg 
65                  70                  75                  80  


Arg Pro Gln Ser Ser Ser Cys Cys Gly Ser Gly Ser Gly Gln Gln Ser 
                85                  90                  95      


Gly Gly Ser Ser Cys Cys His Ser Ser Gly Gly Ser Gly Cys Cys His 
            100                 105                 110         


Ser Ser Gly Gly Cys Cys 
        115             


<210>  6124
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCK__Homo_sapiens__XP_011539756

<400>  6124

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Gly Asp 
    50                  55                  60                  


Pro Arg Gln Gln Gly Leu Lys Asp Lys Ala Cys Gly Ser Leu Ala Val 
65                  70                  75                  80  


Gly Phe His Leu Ser Pro Thr Tyr Phe Leu Pro Gly Leu Ala Phe Leu 
                85                  90                  95      


Val Pro His Pro Val Thr Pro Gly Phe Leu Pro Ile Pro Ala Arg Phe 
            100                 105                 110         


Ser Leu Met Pro Leu Val Phe Thr Asp Asn Leu Val Ile Ala Leu His 
        115                 120                 125             


Ser Tyr Glu Pro Ser His Asp Gly Asp Leu Gly Phe Glu Lys Gly Glu 
    130                 135                 140                 


Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu Trp Trp Lys Ala Gln Ser 
145                 150                 155                 160 


Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro Phe Asn Phe Val Ala Lys 
                165                 170                 175     


Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe Phe Lys Asn Leu Ser Arg 
            180                 185                 190         


Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro Gly Asn Thr His Gly Ser 
        195                 200                 205             


Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala Gly Ser Phe Ser Leu Ser 
    210                 215                 220                 


Val Arg Asp Phe Asp Gln Asn Gln Gly Glu Val Val Lys His Tyr Lys 
225                 230                 235                 240 


Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr Ile Ser Pro Arg Ile Thr 
                245                 250                 255     


Phe Pro Gly Leu His Glu Leu Val Arg His Tyr Thr Arg Tyr Tyr Asn 
            260                 265                 270         


Gly His Thr Lys Val Ala Val Lys Ser Leu Lys Gln Gly Ser Met Ser 
        275                 280                 285             


Pro Asp Ala Phe Leu Ala Glu Ala Asn Leu Met Lys Gln Leu Gln His 
    290                 295                 300                 


Gln Arg Leu Val Arg Leu Tyr Ala Val Val Thr Gln Glu Pro Ile Tyr 
305                 310                 315                 320 


Ile Ile Thr Glu Tyr Met Glu Asn Gly Ser Leu Val Asp Phe Leu Lys 
                325                 330                 335     


Thr Pro Ser Gly Ile Lys Leu Thr Ile Asn Lys Leu Leu Asp Met Ala 
            340                 345                 350         


Ala Gln Ile Ala Glu Gly Met Ala Phe Ile Glu Glu Arg Asn Tyr Ile 
        355                 360                 365             


His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Ser Asp Thr Leu Ser 
    370                 375                 380                 


Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp Asn Glu 
385                 390                 395                 400 


Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro 
                405                 410                 415     


Glu Ala Ile Asn Tyr Gly Thr Phe Thr Ile Lys Ser Asp Val Trp Ser 
            420                 425                 430         


Phe Gly Ile Leu Leu Thr Glu Ile Val Thr His Gly Arg Ile Pro Tyr 
        435                 440                 445             


Pro Gly Met Thr Asn Pro Glu Val Ile Gln Asn Leu Glu Arg Gly Tyr 
    450                 455                 460                 


Arg Met Val Arg Pro Asp Asn Cys Pro Glu Glu Leu Tyr Gln Leu Met 
465                 470                 475                 480 


Arg Leu Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro Thr Phe Asp Tyr 
                485                 490                 495     


Leu Arg Ser Val Leu Glu Asp Phe Phe Thr Ala Thr Glu Gly Gln Tyr 
            500                 505                 510         


Gln Pro Gln Pro 
        515     


<210>  6125
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCLAT1__Homo_sapiens__NP_001291374

<400>  6125

Met Val Ser Trp Lys Gly Ile Tyr Phe Ile Leu Thr Leu Phe Trp Gly 
1               5                   10                  15      


Ser Phe Phe Gly Ser Ile Phe Met Leu Ser Pro Phe Leu Pro Leu Met 
            20                  25                  30          


Phe Val Asn Pro Ser Trp Tyr Arg Trp Ile Asn Asn Arg Leu Val Ala 
        35                  40                  45              


Thr Trp Leu Thr Leu Pro Val Ala Leu Leu Glu Thr Met Phe Gly Val 
    50                  55                  60                  


Lys Val Ile Ile Thr Gly Asp Ala Phe Val Pro Gly Glu Arg Ser Val 
65                  70                  75                  80  


Ile Ile Met Asn His Arg Thr Arg Met Asp Trp Met Phe Leu Trp Asn 
                85                  90                  95      


Cys Leu Met Arg Tyr Ser Tyr Leu Arg Leu Glu Lys Ile Cys Leu Lys 
            100                 105                 110         


Ala Ser Leu Lys Gly Val Pro Gly Phe Gly Trp Ala Met Gln Ala Ala 
        115                 120                 125             


Ala Tyr Ile Phe Ile His Arg Lys Trp Lys Asp Asp Lys Ser His Phe 
    130                 135                 140                 


Glu Asp Met Ile Asp Tyr Phe Cys Asp Ile His Glu Pro Leu Gln Leu 
145                 150                 155                 160 


Leu Ile Phe Pro Glu Gly Thr Asp Leu Thr Glu Asn Ser Lys Ser Arg 
                165                 170                 175     


Ser Asn Ala Phe Ala Glu Lys Asn Gly Leu Gln Lys Tyr Glu Tyr Val 
            180                 185                 190         


Leu His Pro Arg Thr Thr Gly Phe Thr Phe Val Val Asp Arg Leu Arg 
        195                 200                 205             


Glu Gly Lys Asn Leu Asp Ala Val His Asp Ile Thr Val Ala Tyr Pro 
    210                 215                 220                 


His Asn Ile Pro Gln Ser Glu Lys His Leu Leu Gln Gly Asp Phe Pro 
225                 230                 235                 240 


Arg Glu Ile His Phe His Val His Arg Tyr Pro Ile Asp Thr Leu Pro 
                245                 250                 255     


Thr Ser Lys Glu Asp Leu Gln Leu Trp Cys His Lys Arg Trp Glu Glu 
            260                 265                 270         


Lys Glu Glu Arg Leu Arg Ser Phe Tyr Gln Gly Glu Lys Asn Phe Tyr 
        275                 280                 285             


Phe Thr Gly Gln Ser Val Ile Pro Pro Cys Lys Ser Glu Leu Arg Val 
    290                 295                 300                 


Leu Val Val Lys Leu Leu Ser Ile Leu Tyr Trp Thr Leu Phe Ser Pro 
305                 310                 315                 320 


Ala Met Cys Leu Leu Ile Tyr Leu Tyr Ser Leu Val Lys Trp Tyr Phe 
                325                 330                 335     


Ile Ile Thr Ile Val Ile Phe Val Leu Gln Glu Arg Ile Phe Gly Gly 
            340                 345                 350         


Leu Glu Ile Ile Glu Leu Ala Cys Tyr Arg Leu Leu His Lys Gln Pro 
        355                 360                 365             


His Leu Asn Ser Lys Lys Asn Glu 
    370                 375     


<210>  6126
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCMT1__Homo_sapiens__NP_001027563

<400>  6126

Met Ala Thr Arg Gln Arg Glu Ser Ser Ile Thr Ser Cys Cys Ser Thr 
1               5                   10                  15      


Ser Ser Cys Asp Ala Asp Asp Glu Gly Val Arg Gly Thr Cys Glu Asp 
            20                  25                  30          


Ala Ser Leu Cys Lys Arg Phe Ala Val Ser Ile Gly Tyr Trp His Asp 
        35                  40                  45              


Pro Tyr Ile Gln His Phe Val Arg Leu Ser Lys Glu Arg Lys Ala Pro 
    50                  55                  60                  


Glu Ile Asn Arg Gly Tyr Phe Ala Arg Val His Gly Val Ser Gln Leu 
65                  70                  75                  80  


Ile Lys Ala Phe Leu Arg Lys Thr Glu Cys His Cys Gln Ile Val Asn 
                85                  90                  95      


Leu Gly Ala Gly Met Asp Thr Thr Phe Trp Arg Leu Lys Asp Glu Asp 
            100                 105                 110         


Leu Leu Pro Ser Lys Tyr Phe Glu Val Asp Phe Pro Met Ile Val Thr 
        115                 120                 125             


Arg Lys Leu His Ser Ile Lys Leu Pro Thr Leu Leu Ile Ala Glu Cys 
    130                 135                 140                 


Val Leu Val Tyr Met Thr Pro Glu Gln Ser Ala Asn Leu Leu Lys Trp 
145                 150                 155                 160 


Ala Ala Asn Ser Phe Glu Arg Ala Met Phe Ile Asn Tyr Glu Gln Val 
                165                 170                 175     


Asn Met Gly Asp Arg Phe Gly Gln Ile Met Ile Glu Asn Leu Arg Arg 
            180                 185                 190         


Arg Gln Cys Asp Leu Ala Gly Val Glu Thr Cys Lys Ser Leu Glu Ser 
        195                 200                 205             


Gln Lys Glu Arg Leu Leu Ser Asn Gly Trp Glu Thr Ala Ser Ala Val 
    210                 215                 220                 


Asp Met Met Glu Leu Tyr Asn Arg Leu Pro Arg Ala Glu Val Ser Arg 
225                 230                 235                 240 


Ile Glu Ser Leu Glu Phe Leu Asp Glu Met Glu Leu Leu Glu Gln Leu 
                245                 250                 255     


Met Arg His Tyr Cys Leu Cys Trp Ala Thr Lys Gly Gly Asn Glu Leu 
            260                 265                 270         


Gly Leu Lys Glu Ile Thr Tyr 
        275                 


<210>  6127
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCN1__Homo_sapiens__NP_001239546

<400>  6127

Met Lys Pro Leu Leu Leu Ala Val Ser Leu Gly Leu Ile Ala Ala Leu 
1               5                   10                  15      


Gln Ala His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser 
            20                  25                  30          


Gly Thr Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu 
        35                  40                  45              


Met Asn Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly 
    50                  55                  60                  


Gly Asn Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln 
65                  70                  75                  80  


Glu Val Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr 
                85                  90                  95      


Ala Asp Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys 
            100                 105                 110         


Asp His Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val 
        115                 120                 125             


Arg Gly Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala 
    130                 135                 140                 


Leu Glu Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu 
145                 150                 155                 160 


Ser Ile Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
                165                 170                 175     


<210>  6128
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCN2__Homo_sapiens__NP_005555

<400>  6128

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  6129
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCOR__Homo_sapiens__NP_001164237

<400>  6129

Met Gln Arg Met Ile Gln Gln Phe Ala Ala Glu Tyr Thr Ser Lys Asn 
1               5                   10                  15      


Ser Ser Thr Gln Asp Pro Ser Gln Pro Asn Ser Thr Lys Asn Gln Ser 
            20                  25                  30          


Leu Pro Lys Ala Ser Pro Val Thr Thr Ser Pro Thr Ala Ala Thr Thr 
        35                  40                  45              


Gln Asn Pro Val Leu Ser Lys Leu Leu Met Ala Asp Gln Asp Ser Pro 
    50                  55                  60                  


Leu Asp Leu Thr Val Arg Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp 
65                  70                  75                  80  


Gly Val Leu Asp Leu Ser Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr 
                85                  90                  95      


Ser Leu Ser His Ser Pro Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg 
            100                 105                 110         


Pro Gly Arg Pro Ser Gln Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp 
        115                 120                 125             


Gly Val Pro Pro Arg Ser Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly 
    130                 135                 140                 


His Ser Thr Ser Leu Lys Val Pro Leu Ala Arg Ser Leu Gln Ile Ser 
145                 150                 155                 160 


Glu Glu Leu Leu Ser Arg Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly 
                165                 170                 175     


Pro Ser Gly Leu Gln Asn His Gly Gln His Leu Ile Leu Ser Arg Glu 
            180                 185                 190         


Ala Ser Trp Ala Lys Pro His Tyr Glu Phe Asn Leu Ser Arg Met Lys 
        195                 200                 205             


Phe Arg Gly Asn Gly Ala Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu 
    210                 215                 220                 


Ala Glu Asn Ser Ala Phe Pro Lys Met Ala Leu Gln Ala Lys Gln Asp 
225                 230                 235                 240 


Gly Lys Lys Asp Val Ser His Ser Ser Pro Val Asp Leu Lys Ile Pro 
                245                 250                 255     


Gln Val Arg Gly Met Asp Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln 
            260                 265                 270         


Tyr Ser Tyr Ser Ser Leu Val Met Gly Ser Gln Thr Glu Ser Ala Leu 
        275                 280                 285             


Ser Lys Lys Leu Arg Ala Ile Leu Pro Lys Gln Ser Arg Lys Ser Met 
    290                 295                 300                 


Leu Asp Ala Gly Pro Asp Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr 
305                 310                 315                 320 


Ser Gly Gln Pro Tyr Pro Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser 
                325                 330                 335     


Lys Gln Pro Arg Lys Lys Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu 
            340                 345                 350         


Ile Leu Glu Glu Ala Ile Ser Val Val Met Ser Gly Lys Met Ser Val 
        355                 360                 365             


Ser Lys Ala Gln Ser Ile Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr 
    370                 375                 380                 


Lys Val Lys Glu Arg Leu Gly Thr Leu Lys Asn Pro Pro Lys Lys Lys 
385                 390                 395                 400 


Met Lys Leu Met Ser Gly 
                405     


<210>  6130
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCP1__Homo_sapiens__XP_005266431

<400>  6130

Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         


<210>  6131
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCP2__Homo_sapiens__NP_005556

<400>  6131

Met Ala Leu Arg Asn Val Pro Phe Arg Ser Glu Val Leu Gly Trp Asp 
1               5                   10                  15      


Pro Asp Ser Leu Ala Asp Tyr Phe Lys Lys Leu Asn Tyr Lys Asp Cys 
            20                  25                  30          


Glu Lys Ala Val Lys Lys Tyr His Ile Asp Gly Ala Arg Phe Leu Asn 
        35                  40                  45              


Leu Thr Glu Asn Asp Ile Gln Lys Phe Pro Lys Leu Arg Val Pro Ile 
    50                  55                  60                  


Leu Ser Lys Leu Ser Gln Glu Ile Asn Lys Asn Glu Glu Arg Arg Ser 
65                  70                  75                  80  


Ile Phe Thr Arg Lys Pro Gln Val Pro Arg Phe Pro Glu Glu Thr Glu 
                85                  90                  95      


Ser His Glu Glu Asp Asn Gly Gly Trp Ser Ser Phe Glu Glu Asp Asp 
            100                 105                 110         


Tyr Glu Ser Pro Asn Asp Asp Gln Asp Gly Glu Asp Asp Gly Asp Tyr 
        115                 120                 125             


Glu Ser Pro Asn Glu Glu Glu Glu Ala Pro Val Glu Asp Asp Ala Asp 
    130                 135                 140                 


Tyr Glu Pro Pro Pro Ser Asn Asp Glu Glu Ala Leu Gln Asn Ser Ile 
145                 150                 155                 160 


Leu Pro Ala Lys Pro Phe Pro Asn Ser Asn Ser Met Tyr Ile Asp Arg 
                165                 170                 175     


Pro Pro Ser Gly Lys Thr Pro Gln Gln Pro Pro Val Pro Pro Gln Arg 
            180                 185                 190         


Pro Met Ala Ala Leu Pro Pro Pro Pro Ala Gly Arg Asn His Ser Pro 
        195                 200                 205             


Leu Pro Pro Pro Gln Thr Asn His Glu Glu Pro Ser Arg Ser Arg Asn 
    210                 215                 220                 


His Lys Thr Ala Lys Leu Pro Ala Pro Ser Ile Asp Arg Ser Thr Lys 
225                 230                 235                 240 


Pro Pro Leu Asp Arg Ser Leu Ala Pro Phe Asp Arg Glu Pro Phe Thr 
                245                 250                 255     


Leu Gly Lys Lys Pro Pro Phe Ser Asp Lys Pro Ser Ile Pro Ala Gly 
            260                 265                 270         


Arg Ser Leu Gly Glu His Leu Pro Lys Ile Gln Lys Pro Pro Leu Pro 
        275                 280                 285             


Pro Thr Thr Glu Arg His Glu Arg Ser Ser Pro Leu Pro Gly Lys Lys 
    290                 295                 300                 


Pro Pro Val Pro Lys His Gly Trp Gly Pro Asp Arg Arg Glu Asn Asp 
305                 310                 315                 320 


Glu Asp Asp Val His Gln Arg Pro Leu Pro Gln Pro Ala Leu Leu Pro 
                325                 330                 335     


Met Ser Ser Asn Thr Phe Pro Ser Arg Ser Thr Lys Pro Ser Pro Met 
            340                 345                 350         


Asn Pro Leu Pro Ser Ser His Met Pro Gly Ala Phe Ser Glu Ser Asn 
        355                 360                 365             


Ser Ser Phe Pro Gln Ser Ala Ser Leu Pro Pro Tyr Phe Ser Gln Gly 
    370                 375                 380                 


Pro Ser Asn Arg Pro Pro Ile Arg Ala Glu Gly Arg Asn Phe Pro Leu 
385                 390                 395                 400 


Pro Leu Pro Asn Lys Pro Arg Pro Pro Ser Pro Ala Glu Glu Glu Asn 
                405                 410                 415     


Ser Leu Asn Glu Glu Trp Tyr Val Ser Tyr Ile Thr Arg Pro Glu Ala 
            420                 425                 430         


Glu Ala Ala Leu Arg Lys Ile Asn Gln Asp Gly Thr Phe Leu Val Arg 
        435                 440                 445             


Asp Ser Ser Lys Lys Thr Thr Thr Asn Pro Tyr Val Leu Met Val Leu 
    450                 455                 460                 


Tyr Lys Asp Lys Val Tyr Asn Ile Gln Ile Arg Tyr Gln Lys Glu Ser 
465                 470                 475                 480 


Gln Val Tyr Leu Leu Gly Thr Gly Leu Arg Gly Lys Glu Asp Phe Leu 
                485                 490                 495     


Ser Val Ser Asp Ile Ile Asp Tyr Phe Arg Lys Met Pro Leu Leu Leu 
            500                 505                 510         


Ile Asp Gly Lys Asn Arg Gly Ser Arg Tyr Gln Cys Thr Leu Thr His 
        515                 520                 525             


Ala Ala Gly Tyr Pro 
    530             


<210>  6132
<211>  1927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCT__Homo_sapiens__NP_002290

<400>  6132

Met Glu Leu Ser Trp His Val Val Phe Ile Ala Leu Leu Ser Phe Ser 
1               5                   10                  15      


Cys Trp Gly Ser Asp Trp Glu Ser Asp Arg Asn Phe Ile Ser Thr Ala 
            20                  25                  30          


Gly Pro Leu Thr Asn Asp Leu Leu His Asn Leu Ser Gly Leu Leu Gly 
        35                  40                  45              


Asp Gln Ser Ser Asn Phe Val Ala Gly Asp Lys Asp Met Tyr Val Cys 
    50                  55                  60                  


His Gln Pro Leu Pro Thr Phe Leu Pro Glu Tyr Phe Ser Ser Leu His 
65                  70                  75                  80  


Ala Ser Gln Ile Thr His Tyr Lys Val Phe Leu Ser Trp Ala Gln Leu 
                85                  90                  95      


Leu Pro Ala Gly Ser Thr Gln Asn Pro Asp Glu Lys Thr Val Gln Cys 
            100                 105                 110         


Tyr Arg Arg Leu Leu Lys Ala Leu Lys Thr Ala Arg Leu Gln Pro Met 
        115                 120                 125             


Val Ile Leu His His Gln Thr Leu Pro Ala Ser Thr Leu Arg Arg Thr 
    130                 135                 140                 


Glu Ala Phe Ala Asp Leu Phe Ala Asp Tyr Ala Thr Phe Ala Phe His 
145                 150                 155                 160 


Ser Phe Gly Asp Leu Val Gly Ile Trp Phe Thr Phe Ser Asp Leu Glu 
                165                 170                 175     


Glu Val Ile Lys Glu Leu Pro His Gln Glu Ser Arg Ala Ser Gln Leu 
            180                 185                 190         


Gln Thr Leu Ser Asp Ala His Arg Lys Ala Tyr Glu Ile Tyr His Glu 
        195                 200                 205             


Ser Tyr Ala Phe Gln Gly Gly Lys Leu Ser Val Val Leu Arg Ala Glu 
    210                 215                 220                 


Asp Ile Pro Glu Leu Leu Leu Glu Pro Pro Ile Ser Ala Leu Ala Gln 
225                 230                 235                 240 


Asp Thr Val Asp Phe Leu Ser Leu Asp Leu Ser Tyr Glu Cys Gln Asn 
                245                 250                 255     


Glu Ala Ser Leu Arg Gln Lys Leu Ser Lys Leu Gln Thr Ile Glu Pro 
            260                 265                 270         


Lys Val Lys Val Phe Ile Phe Asn Leu Lys Leu Pro Asp Cys Pro Ser 
        275                 280                 285             


Thr Met Lys Asn Pro Ala Ser Leu Leu Phe Ser Leu Phe Glu Ala Ile 
    290                 295                 300                 


Asn Lys Asp Gln Val Leu Thr Ile Gly Phe Asp Ile Asn Glu Phe Leu 
305                 310                 315                 320 


Ser Cys Ser Ser Ser Ser Lys Lys Ser Met Ser Cys Ser Leu Thr Gly 
                325                 330                 335     


Ser Leu Ala Leu Gln Pro Asp Gln Gln Gln Asp His Glu Thr Thr Asp 
            340                 345                 350         


Ser Ser Pro Ala Ser Ala Tyr Gln Arg Ile Trp Glu Ala Phe Ala Asn 
        355                 360                 365             


Gln Ser Arg Ala Glu Arg Asp Ala Phe Leu Gln Asp Thr Phe Pro Glu 
    370                 375                 380                 


Gly Phe Leu Trp Gly Ala Ser Thr Gly Ala Phe Asn Val Glu Gly Gly 
385                 390                 395                 400 


Trp Ala Glu Gly Gly Arg Gly Val Ser Ile Trp Asp Pro Arg Arg Pro 
                405                 410                 415     


Leu Asn Thr Thr Glu Gly Gln Ala Thr Leu Glu Val Ala Ser Asp Ser 
            420                 425                 430         


Tyr His Lys Val Ala Ser Asp Val Ala Leu Leu Cys Gly Leu Arg Ala 
        435                 440                 445             


Gln Val Tyr Lys Phe Ser Ile Ser Trp Ser Arg Ile Phe Pro Met Gly 
    450                 455                 460                 


His Gly Ser Ser Pro Ser Leu Pro Gly Val Ala Tyr Tyr Asn Lys Leu 
465                 470                 475                 480 


Ile Asp Arg Leu Gln Asp Ala Gly Ile Glu Pro Met Ala Thr Leu Phe 
                485                 490                 495     


His Trp Asp Leu Pro Gln Ala Leu Gln Asp His Gly Gly Trp Gln Asn 
            500                 505                 510         


Glu Ser Val Val Asp Ala Phe Leu Asp Tyr Ala Ala Phe Cys Phe Ser 
        515                 520                 525             


Thr Phe Gly Asp Arg Val Lys Leu Trp Val Thr Phe His Glu Pro Trp 
    530                 535                 540                 


Val Met Ser Tyr Ala Gly Tyr Gly Thr Gly Gln His Pro Pro Gly Ile 
545                 550                 555                 560 


Ser Asp Pro Gly Val Ala Ser Phe Lys Val Ala His Leu Val Leu Lys 
                565                 570                 575     


Ala His Ala Arg Thr Trp His His Tyr Asn Ser His His Arg Pro Gln 
            580                 585                 590         


Gln Gln Gly His Val Gly Ile Val Leu Asn Ser Asp Trp Ala Glu Pro 
        595                 600                 605             


Leu Ser Pro Glu Arg Pro Glu Asp Leu Arg Ala Ser Glu Arg Phe Leu 
    610                 615                 620                 


His Phe Met Leu Gly Trp Phe Ala His Pro Val Phe Val Asp Gly Asp 
625                 630                 635                 640 


Tyr Pro Ala Thr Leu Arg Thr Gln Ile Gln Gln Met Asn Arg Gln Cys 
                645                 650                 655     


Ser His Pro Val Ala Gln Leu Pro Glu Phe Thr Glu Ala Glu Lys Gln 
            660                 665                 670         


Leu Leu Lys Gly Ser Ala Asp Phe Leu Gly Leu Ser His Tyr Thr Ser 
        675                 680                 685             


Arg Leu Ile Ser Asn Ala Pro Gln Asn Thr Cys Ile Pro Ser Tyr Asp 
    690                 695                 700                 


Thr Ile Gly Gly Phe Ser Gln His Val Asn His Val Trp Pro Gln Thr 
705                 710                 715                 720 


Ser Ser Ser Trp Ile Arg Val Val Pro Trp Gly Ile Arg Arg Leu Leu 
                725                 730                 735     


Gln Phe Val Ser Leu Glu Tyr Thr Arg Gly Lys Val Pro Ile Tyr Leu 
            740                 745                 750         


Ala Gly Asn Gly Met Pro Ile Gly Glu Ser Glu Asn Leu Phe Asp Asp 
        755                 760                 765             


Ser Leu Arg Val Asp Tyr Phe Asn Gln Tyr Ile Asn Glu Val Leu Lys 
    770                 775                 780                 


Ala Ile Lys Glu Asp Ser Val Asp Val Arg Ser Tyr Ile Ala Arg Ser 
785                 790                 795                 800 


Leu Ile Asp Gly Phe Glu Gly Pro Ser Gly Tyr Ser Gln Arg Phe Gly 
                805                 810                 815     


Leu His His Val Asn Phe Ser Asp Ser Ser Lys Ser Arg Thr Pro Arg 
            820                 825                 830         


Lys Ser Ala Tyr Phe Phe Thr Ser Ile Ile Glu Lys Asn Gly Phe Leu 
        835                 840                 845             


Thr Lys Gly Ala Lys Arg Leu Leu Pro Pro Asn Thr Val Asn Leu Pro 
    850                 855                 860                 


Ser Lys Val Arg Ala Phe Thr Phe Pro Ser Glu Val Pro Ser Lys Ala 
865                 870                 875                 880 


Lys Val Val Trp Glu Lys Phe Ser Ser Gln Pro Lys Phe Glu Arg Asp 
                885                 890                 895     


Leu Phe Tyr His Gly Thr Phe Arg Asp Asp Phe Leu Trp Gly Val Ser 
            900                 905                 910         


Ser Ser Ala Tyr Gln Ile Glu Gly Ala Trp Asp Ala Asp Gly Lys Gly 
        915                 920                 925             


Pro Ser Ile Trp Asp Asn Phe Thr His Thr Pro Gly Ser Asn Val Lys 
    930                 935                 940                 


Asp Asn Ala Thr Gly Asp Ile Ala Cys Asp Ser Tyr His Gln Leu Asp 
945                 950                 955                 960 


Ala Asp Leu Asn Met Leu Arg Ala Leu Lys Val Lys Ala Tyr Arg Phe 
                965                 970                 975     


Ser Ile Ser Trp Ser Arg Ile Phe Pro Thr Gly Arg Asn Ser Ser Ile 
            980                 985                 990         


Asn Ser His Gly Val Asp Tyr Tyr  Asn Arg Leu Ile Asn  Gly Leu Val 
        995                 1000                 1005             


Ala Ser  Asn Ile Phe Pro Met  Val Thr Leu Phe His  Trp Asp Leu 
    1010                 1015                 1020             


Pro Gln  Ala Leu Gln Asp Ile  Gly Gly Trp Glu Asn  Pro Ala Leu 
    1025                 1030                 1035             


Ile Asp  Leu Phe Asp Ser Tyr  Ala Asp Phe Cys Phe  Gln Thr Phe 
    1040                 1045                 1050             


Gly Asp  Arg Val Lys Phe Trp  Met Thr Phe Asn Glu  Pro Met Tyr 
    1055                 1060                 1065             


Leu Ala  Trp Leu Gly Tyr Gly  Ser Gly Glu Phe Pro  Pro Gly Val 
    1070                 1075                 1080             


Lys Asp  Pro Gly Trp Ala Pro  Tyr Arg Ile Ala His  Ala Val Ile 
    1085                 1090                 1095             


Lys Ala  His Ala Arg Val Tyr  His Thr Tyr Asp Glu  Lys Tyr Arg 
    1100                 1105                 1110             


Gln Glu  Gln Lys Gly Val Ile  Ser Leu Ser Leu Ser  Thr His Trp 
    1115                 1120                 1125             


Ala Glu  Pro Lys Ser Pro Gly  Val Pro Arg Asp Val  Glu Ala Ala 
    1130                 1135                 1140             


Asp Arg  Met Leu Gln Phe Ser  Leu Gly Trp Phe Ala  His Pro Ile 
    1145                 1150                 1155             


Phe Arg  Asn Gly Asp Tyr Pro  Asp Thr Met Lys Trp  Lys Val Gly 
    1160                 1165                 1170             


Asn Arg  Ser Glu Leu Gln His  Leu Ala Thr Ser Arg  Leu Pro Ser 
    1175                 1180                 1185             


Phe Thr  Glu Glu Glu Lys Arg  Phe Ile Arg Ala Thr  Ala Asp Val 
    1190                 1195                 1200             


Phe Cys  Leu Asn Thr Tyr Tyr  Ser Arg Ile Val Gln  His Lys Thr 
    1205                 1210                 1215             


Pro Arg  Leu Asn Pro Pro Ser  Tyr Glu Asp Asp Gln  Glu Met Ala 
    1220                 1225                 1230             


Glu Glu  Glu Asp Pro Ser Trp  Pro Ser Thr Ala Met  Asn Arg Ala 
    1235                 1240                 1245             


Ala Pro  Trp Gly Thr Arg Arg  Leu Leu Asn Trp Ile  Lys Glu Glu 
    1250                 1255                 1260             


Tyr Gly  Asp Ile Pro Ile Tyr  Ile Thr Glu Asn Gly  Val Gly Leu 
    1265                 1270                 1275             


Thr Asn  Pro Asn Thr Glu Asp  Thr Asp Arg Ile Phe  Tyr His Lys 
    1280                 1285                 1290             


Thr Tyr  Ile Asn Glu Ala Leu  Lys Ala Tyr Arg Leu  Asp Gly Ile 
    1295                 1300                 1305             


Asp Leu  Arg Gly Tyr Val Ala  Trp Ser Leu Met Asp  Asn Phe Glu 
    1310                 1315                 1320             


Trp Leu  Asn Gly Tyr Thr Val  Lys Phe Gly Leu Tyr  His Val Asp 
    1325                 1330                 1335             


Phe Asn  Asn Thr Asn Arg Pro  Arg Thr Ala Arg Ala  Ser Ala Arg 
    1340                 1345                 1350             


Tyr Tyr  Thr Glu Val Ile Thr  Asn Asn Gly Met Pro  Leu Ala Arg 
    1355                 1360                 1365             


Glu Asp  Glu Phe Leu Tyr Gly  Arg Phe Pro Glu Gly  Phe Ile Trp 
    1370                 1375                 1380             


Ser Ala  Ala Ser Ala Ala Tyr  Gln Ile Glu Gly Ala  Trp Arg Ala 
    1385                 1390                 1395             


Asp Gly  Lys Gly Leu Ser Ile  Trp Asp Thr Phe Ser  His Thr Pro 
    1400                 1405                 1410             


Leu Arg  Val Glu Asn Asp Ala  Ile Gly Asp Val Ala  Cys Asp Ser 
    1415                 1420                 1425             


Tyr His  Lys Ile Ala Glu Asp  Leu Val Thr Leu Gln  Asn Leu Gly 
    1430                 1435                 1440             


Val Ser  His Tyr Arg Phe Ser  Ile Ser Trp Ser Arg  Ile Leu Pro 
    1445                 1450                 1455             


Asp Gly  Thr Thr Arg Tyr Ile  Asn Glu Ala Gly Leu  Asn Tyr Tyr 
    1460                 1465                 1470             


Val Arg  Leu Ile Asp Thr Leu  Leu Ala Ala Ser Ile  Gln Pro Gln 
    1475                 1480                 1485             


Val Thr  Ile Tyr His Trp Asp  Leu Pro Gln Thr Leu  Gln Asp Val 
    1490                 1495                 1500             


Gly Gly  Trp Glu Asn Glu Thr  Ile Val Gln Arg Phe  Lys Glu Tyr 
    1505                 1510                 1515             


Ala Asp  Val Leu Phe Gln Arg  Leu Gly Asp Lys Val  Lys Phe Trp 
    1520                 1525                 1530             


Ile Thr  Leu Asn Glu Pro Phe  Val Ile Ala Tyr Gln  Gly Tyr Gly 
    1535                 1540                 1545             


Tyr Gly  Thr Ala Ala Pro Gly  Val Ser Asn Arg Pro  Gly Thr Ala 
    1550                 1555                 1560             


Pro Tyr  Ile Val Gly His Asn  Leu Ile Lys Ala His  Ala Glu Ala 
    1565                 1570                 1575             


Trp His  Leu Tyr Asn Asp Val  Tyr Arg Ala Ser Gln  Gly Gly Val 
    1580                 1585                 1590             


Ile Ser  Ile Thr Ile Ser Ser  Asp Trp Ala Glu Pro  Arg Asp Pro 
    1595                 1600                 1605             


Ser Asn  Gln Glu Asp Val Glu  Ala Ala Arg Arg Tyr  Val Gln Phe 
    1610                 1615                 1620             


Met Gly  Gly Trp Phe Ala His  Pro Ile Phe Lys Asn  Gly Asp Tyr 
    1625                 1630                 1635             


Asn Glu  Val Met Lys Thr Arg  Ile Arg Asp Arg Ser  Leu Ala Ala 
    1640                 1645                 1650             


Gly Leu  Asn Lys Ser Arg Leu  Pro Glu Phe Thr Glu  Ser Glu Lys 
    1655                 1660                 1665             


Arg Arg  Ile Asn Gly Thr Tyr  Asp Phe Phe Gly Phe  Asn His Tyr 
    1670                 1675                 1680             


Thr Thr  Val Leu Ala Tyr Asn  Leu Asn Tyr Ala Thr  Ala Ile Ser 
    1685                 1690                 1695             


Ser Phe  Asp Ala Asp Arg Gly  Val Ala Ser Ile Ala  Asp Arg Ser 
    1700                 1705                 1710             


Trp Pro  Asp Ser Gly Ser Phe  Trp Leu Lys Met Thr  Pro Phe Gly 
    1715                 1720                 1725             


Phe Arg  Arg Ile Leu Asn Trp  Leu Lys Glu Glu Tyr  Asn Asp Pro 
    1730                 1735                 1740             


Pro Ile  Tyr Val Thr Glu Asn  Gly Val Ser Gln Arg  Glu Glu Thr 
    1745                 1750                 1755             


Asp Leu  Asn Asp Thr Ala Arg  Ile Tyr Tyr Leu Arg  Thr Tyr Ile 
    1760                 1765                 1770             


Asn Glu  Ala Leu Lys Ala Val  Gln Asp Lys Val Asp  Leu Arg Gly 
    1775                 1780                 1785             


Tyr Thr  Val Trp Ser Ala Met  Asp Asn Phe Glu Trp  Ala Thr Gly 
    1790                 1795                 1800             


Phe Ser  Glu Arg Phe Gly Leu  His Phe Val Asn Tyr  Ser Asp Pro 
    1805                 1810                 1815             


Ser Leu  Pro Arg Ile Pro Lys  Ala Ser Ala Lys Phe  Tyr Ala Ser 
    1820                 1825                 1830             


Val Val  Arg Cys Asn Gly Phe  Pro Asp Pro Ala Thr  Gly Pro His 
    1835                 1840                 1845             


Ala Cys  Leu His Gln Pro Asp  Ala Gly Pro Thr Ile  Ser Pro Val 
    1850                 1855                 1860             


Arg Gln  Glu Glu Val Gln Phe  Leu Gly Leu Met Leu  Gly Thr Thr 
    1865                 1870                 1875             


Glu Ala  Gln Thr Ala Leu Tyr  Val Leu Phe Ser Leu  Val Leu Leu 
    1880                 1885                 1890             


Gly Val  Cys Gly Leu Ala Phe  Leu Ser Tyr Lys Tyr  Cys Lys Arg 
    1895                 1900                 1905             


Ser Lys  Gln Gly Lys Thr Gln  Arg Ser Gln Gln Glu  Leu Ser Pro 
    1910                 1915                 1920             


Val Ser  Ser Phe 
    1925         


<210>  6133
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDB1__Homo_sapiens__NP_001106878

<400>  6133

Met Ser Val Gly Cys Ala Cys Pro Gly Cys Ser Ser Lys Ser Phe Lys 
1               5                   10                  15      


Leu Tyr Ser Pro Lys Glu Pro Pro Asn Gly Asn Ala Phe Pro Pro Phe 
            20                  25                  30          


His Pro Gly Thr Met Leu Asp Arg Asp Val Gly Pro Thr Pro Met Tyr 
        35                  40                  45              


Pro Pro Thr Tyr Leu Glu Pro Gly Ile Gly Arg His Thr Pro Tyr Gly 
    50                  55                  60                  


Asn Gln Thr Asp Tyr Arg Ile Phe Glu Leu Asn Lys Arg Leu Gln Asn 
65                  70                  75                  80  


Trp Thr Glu Glu Cys Asp Asn Leu Trp Trp Asp Ala Phe Thr Thr Glu 
                85                  90                  95      


Phe Phe Glu Asp Asp Ala Met Leu Thr Ile Thr Phe Cys Leu Glu Asp 
            100                 105                 110         


Gly Pro Lys Arg Tyr Thr Ile Gly Arg Thr Leu Ile Pro Arg Tyr Phe 
        115                 120                 125             


Arg Ser Ile Phe Glu Gly Gly Ala Thr Glu Leu Tyr Tyr Val Leu Lys 
    130                 135                 140                 


His Pro Lys Glu Ala Phe His Ser Asn Phe Val Ser Leu Asp Cys Asp 
145                 150                 155                 160 


Gln Gly Ser Met Val Thr Gln His Gly Lys Pro Met Phe Thr Gln Val 
                165                 170                 175     


Cys Val Glu Gly Arg Leu Tyr Leu Glu Phe Met Phe Asp Asp Met Met 
            180                 185                 190         


Arg Ile Lys Thr Trp His Phe Ser Ile Arg Gln His Arg Glu Leu Ile 
        195                 200                 205             


Pro Arg Ser Ile Leu Ala Met His Ala Gln Asp Pro Gln Met Leu Asp 
    210                 215                 220                 


Gln Leu Ser Lys Asn Ile Thr Arg Cys Gly Leu Ser Asn Ser Thr Leu 
225                 230                 235                 240 


Asn Tyr Leu Arg Leu Cys Val Ile Leu Glu Pro Met Gln Glu Leu Met 
                245                 250                 255     


Ser Arg His Lys Thr Tyr Ser Leu Ser Pro Arg Asp Cys Leu Lys Thr 
            260                 265                 270         


Cys Leu Phe Gln Lys Trp Gln Arg Met Val Ala Pro Pro Ala Glu Pro 
        275                 280                 285             


Thr Arg Gln Gln Pro Ser Lys Arg Arg Lys Arg Lys Met Ser Gly Gly 
    290                 295                 300                 


Ser Thr Met Ser Ser Gly Gly Gly Asn Thr Asn Asn Ser Asn Ser Lys 
305                 310                 315                 320 


Lys Lys Ser Pro Ala Ser Thr Phe Ala Leu Ser Ser Gln Val Pro Asp 
                325                 330                 335     


Val Met Val Val Gly Glu Pro Thr Leu Met Gly Gly Glu Phe Gly Asp 
            340                 345                 350         


Glu Asp Glu Arg Leu Ile Thr Arg Leu Glu Asn Thr Gln Phe Asp Ala 
        355                 360                 365             


Ala Asn Gly Ile Asp Asp Glu Asp Ser Phe Asn Asn Ser Pro Ala Leu 
    370                 375                 380                 


Gly Ala Asn Ser Pro Trp Asn Ser Lys Pro Pro Ser Ser Gln Glu Ser 
385                 390                 395                 400 


Lys Ser Glu Asn Pro Thr Ser Gln Ala Ser Gln 
                405                 410     


<210>  6134
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDB2__Homo_sapiens__NP_001124306

<400>  6134

Met Ser Ser Thr Pro His Asp Pro Phe Tyr Ser Ser Pro Phe Gly Pro 
1               5                   10                  15      


Phe Tyr Arg Arg His Thr Pro Tyr Met Val Gln Pro Glu Tyr Arg Ile 
            20                  25                  30          


Tyr Glu Met Asn Lys Arg Leu Gln Ser Arg Thr Glu Asp Ser Asp Asn 
        35                  40                  45              


Leu Trp Trp Asp Ala Phe Ala Thr Glu Phe Phe Glu Asp Asp Ala Thr 
    50                  55                  60                  


Leu Thr Leu Ser Phe Cys Leu Glu Asp Gly Pro Lys Arg Tyr Thr Ile 
65                  70                  75                  80  


Gly Arg Thr Leu Ile Pro Arg Tyr Phe Ser Thr Val Phe Glu Gly Gly 
                85                  90                  95      


Val Thr Asp Leu Tyr Tyr Ile Leu Lys His Ser Lys Glu Ser Tyr His 
            100                 105                 110         


Asn Ser Ser Ile Thr Val Asp Cys Asp Gln Cys Thr Met Val Thr Gln 
        115                 120                 125             


His Gly Lys Pro Met Phe Thr Lys Val Cys Thr Glu Gly Arg Leu Ile 
    130                 135                 140                 


Leu Glu Phe Thr Phe Asp Asp Leu Met Arg Ile Lys Thr Trp His Phe 
145                 150                 155                 160 


Thr Ile Arg Gln Tyr Arg Glu Leu Val Pro Arg Ser Ile Leu Ala Met 
                165                 170                 175     


His Ala Gln Asp Pro Gln Val Leu Asp Gln Leu Ser Lys Asn Ile Thr 
            180                 185                 190         


Arg Met Gly Leu Thr Asn Phe Thr Leu Asn Tyr Leu Arg Leu Cys Val 
        195                 200                 205             


Ile Leu Glu Pro Met Gln Glu Leu Met Ser Arg His Lys Thr Tyr Asn 
    210                 215                 220                 


Leu Ser Pro Arg Asp Cys Leu Lys Thr Cys Leu Phe Gln Lys Trp Gln 
225                 230                 235                 240 


Arg Met Val Ala Pro Pro Ala Glu Pro Thr Arg Gln Pro Thr Thr Lys 
                245                 250                 255     


Arg Arg Lys Arg Lys Asn Ser Thr Ser Ser Thr Ser Asn Ser Ser Ala 
            260                 265                 270         


Gly Asn Asn Ala Asn Ser Thr Gly Ser Lys Lys Lys Thr Thr Ala Ala 
        275                 280                 285             


Asn Leu Ser Leu Ser Ser Gln Val Pro Gly Leu Gly Ala Ile Pro Asn 
    290                 295                 300                 


Cys Ser Leu Asn Pro Gly Arg Asp Gly Asp Leu Cys His Ser Thr Ala 
305                 310                 315                 320 


Val Thr Pro Ser Gly Gln Phe Lys Glu Lys His 
                325                 330     


<210>  6135
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDB3__Homo_sapiens__NP_001073583

<400>  6135

Met Ser Tyr Ser Val Thr Leu Thr Gly Pro Gly Pro Trp Gly Phe Arg 
1               5                   10                  15      


Leu Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Arg Ile 
            20                  25                  30          


Thr Pro Gly Ser Lys Ala Ala Gln Ser Gln Leu Ser Gln Gly Asp Leu 
        35                  40                  45              


Val Val Ala Ile Asp Gly Val Asn Thr Asp Thr Met Thr His Leu Glu 
    50                  55                  60                  


Ala Gln Asn Lys Ile Lys Ser Ala Ser Tyr Asn Leu Ser Leu Thr Leu 
65                  70                  75                  80  


Gln Lys Ser Lys Arg Pro Ile Pro Ile Ser Thr Thr Ala Pro Pro Val 
                85                  90                  95      


Gln Thr Pro Leu Pro Val Ile Pro His Gln Lys Val Val Val Asn Ser 
            100                 105                 110         


Pro Ala Asn Ala Asp Tyr Gln Glu Arg Phe Asn Pro Ser Ala Leu Lys 
        115                 120                 125             


Asp Ser Ala Leu Ser Thr His Lys Pro Ile Glu Val Lys Gly Leu Gly 
    130                 135                 140                 


Gly Lys Ala Thr Ile Ile His Ala Gln Tyr Asn Thr Pro Ile Ser Met 
145                 150                 155                 160 


Tyr Ser Gln Asp Ala Ile Met Asp Ala Ile Ala Gly Gln Ala Gln Ala 
                165                 170                 175     


Gln Gly Ser Asp Phe Ser Gly Ser Leu Pro Ile Lys Asp Leu Ala Val 
            180                 185                 190         


Asp Ser Ala Ser Pro Val Tyr Gln Ala Val Ile Lys Ser Gln Asn Lys 
        195                 200                 205             


Pro Glu Asp Glu Ala Asp Glu Trp Ala Arg Arg Ser Ser Asn Leu Gln 
    210                 215                 220                 


Ser Arg Ser Phe Arg Ile Leu Ala Gln Met Thr Gly Thr Glu Phe Met 
225                 230                 235                 240 


Gln Asp Pro Asp Glu Glu Ala Leu Arg Arg Ser Arg Pro Gln Ala Ser 
                245                 250                 255     


Ser Tyr Ser Pro Ala Val Ala Ala Ser Ser Ala Pro Ala Thr His Thr 
            260                 265                 270         


Ser Tyr Ser Glu Gly Pro Ala Ala Pro Ala Pro Lys Pro Arg Val Val 
        275                 280                 285             


Thr Thr Ala Ser Ile Arg Pro Ser Val Tyr Gln Pro Val Pro Ala Ser 
    290                 295                 300                 


Thr Tyr Ser Pro Ser Pro Gly Ala Asn Tyr Ser Pro Thr Pro Tyr Thr 
305                 310                 315                 320 


Pro Ser Pro Ala Pro Ala Tyr Thr Pro Ser Pro Ala Pro Ala Tyr Thr 
                325                 330                 335     


Pro Ser Pro Val Pro Thr Tyr Thr Pro Ser Pro Ala Pro Ala Tyr Thr 
            340                 345                 350         


Pro Ser Pro Ala Pro Asn Tyr Asn Pro Ala Pro Ser Val Ala Tyr Ser 
        355                 360                 365             


Gly Gly Pro Ala Glu Pro Ala Ser Arg Pro Pro Trp Val Thr Asp Asp 
    370                 375                 380                 


Ser Phe Ser Gln Lys Phe Ala Pro Gly Lys Ser Thr Thr Ser Ile Ser 
385                 390                 395                 400 


Lys Gln Thr Leu Pro Arg Gly Gly Pro Ala Tyr Thr Pro Ala Gly Pro 
                405                 410                 415     


Gln Val Pro Pro Leu Ala Arg Gly Thr Val Gln Arg Ala Glu Arg Phe 
            420                 425                 430         


Pro Ala Ser Ser Arg Thr Pro Leu Cys Gly His Cys Asn Asn Val Ile 
        435                 440                 445             


Arg Gly Pro Phe Leu Val Ala Met Gly Arg Ser Trp His Pro Glu Glu 
    450                 455                 460                 


Phe Thr Cys Ala Tyr Cys Lys Thr Ser Leu Ala Asp Val Cys Phe Val 
465                 470                 475                 480 


Glu Glu Gln Asn Asn Val Tyr Cys Glu Arg Cys Tyr Glu Gln Phe Phe 
                485                 490                 495     


Ala Pro Leu Cys Ala Lys Cys Asn Thr Lys Ile Met Gly Glu Val Met 
            500                 505                 510         


His Ala Leu Arg Gln Thr Trp His Thr Thr Cys Phe Val Cys Ala Ala 
        515                 520                 525             


Cys Lys Lys Pro Phe Gly Asn Ser Leu Phe His Met Glu Asp Gly Glu 
    530                 535                 540                 


Pro Tyr Cys Glu Lys Asp Tyr Ile Asn Leu Phe Ser Thr Lys Cys His 
545                 550                 555                 560 


Gly Cys Asp Phe Pro Val Glu Ala Gly Asp Lys Phe Ile Glu Ala Leu 
                565                 570                 575     


Gly His Thr Trp His Asp Thr Cys Phe Ile Cys Ala Val Cys His Val 
            580                 585                 590         


Asn Leu Glu Gly Gln Pro Phe Tyr Ser Lys Lys Asp Arg Pro Leu Cys 
        595                 600                 605             


Lys Lys His Ala His Thr Ile Asn Leu 
    610                 615         


<210>  6136
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDHA__Homo_sapiens__NP_001128711

<400>  6136

Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Val Asp Ile Leu Thr Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro 
                85                  90                  95      


Lys Asn Arg Val Ile Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe 
            100                 105                 110         


Arg Tyr Leu Met Gly Glu Arg Leu Gly Val His Pro Leu Ser Cys His 
        115                 120                 125             


Gly Trp Val Leu Gly Glu His Gly Asp Ser Ser Val Pro Val Trp Ser 
    130                 135                 140                 


Gly Met Asn Val Ala Gly Val Ser Leu Lys Thr Leu His Pro Asp Leu 
145                 150                 155                 160 


Gly Thr Asp Lys Asp Lys Glu Gln Trp Lys Glu Val His Lys Gln Val 
                165                 170                 175     


Val Glu Ser Ala Tyr Glu Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp 
            180                 185                 190         


Ala Ile Gly Leu Ser Val Ala Asp Leu Ala Glu Ser Ile Met Lys Asn 
        195                 200                 205             


Leu Arg Arg Val His Pro Val Ser Thr Met Ile Lys Gly Leu Tyr Gly 
    210                 215                 220                 


Ile Lys Asp Asp Val Phe Leu Ser Val Pro Cys Ile Leu Gly Gln Asn 
225                 230                 235                 240 


Gly Ile Ser Asp Leu Val Lys Val Thr Leu Thr Ser Glu Glu Glu Ala 
                245                 250                 255     


Arg Leu Lys Lys Ser Ala Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu 
            260                 265                 270         


Gln Phe 
        


<210>  6137
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDHAL6B__Homo_sapiens__NP_149972

<400>  6137

Met Ser Trp Thr Val Pro Val Val Arg Ala Ser Gln Arg Val Ser Ser 
1               5                   10                  15      


Val Gly Ala Asn Phe Leu Cys Leu Gly Met Ala Leu Cys Pro Arg Gln 
            20                  25                  30          


Ala Thr Arg Ile Pro Leu Asn Gly Thr Trp Leu Phe Thr Pro Val Ser 
        35                  40                  45              


Lys Met Ala Thr Val Lys Ser Glu Leu Ile Glu Arg Phe Thr Ser Glu 
    50                  55                  60                  


Lys Pro Val His His Ser Lys Val Ser Ile Ile Gly Thr Gly Ser Val 
65                  70                  75                  80  


Gly Met Ala Cys Ala Ile Ser Ile Leu Leu Lys Gly Leu Ser Asp Glu 
                85                  90                  95      


Leu Ala Leu Val Asp Leu Asp Glu Asp Lys Leu Lys Gly Glu Thr Met 
            100                 105                 110         


Asp Leu Gln His Gly Ser Pro Phe Thr Lys Met Pro Asn Ile Val Cys 
        115                 120                 125             


Ser Lys Asp Tyr Phe Val Thr Ala Asn Ser Asn Leu Val Ile Ile Thr 
    130                 135                 140                 


Ala Gly Ala Arg Gln Glu Lys Gly Glu Thr Arg Leu Asn Leu Val Gln 
145                 150                 155                 160 


Arg Asn Val Ala Ile Phe Lys Leu Met Ile Ser Ser Ile Val Gln Tyr 
                165                 170                 175     


Ser Pro His Cys Lys Leu Ile Ile Val Ser Asn Pro Val Asp Ile Leu 
            180                 185                 190         


Thr Tyr Val Ala Trp Lys Leu Ser Ala Phe Pro Lys Asn Arg Ile Ile 
        195                 200                 205             


Gly Ser Gly Cys Asn Leu Asp Thr Ala Arg Phe Arg Phe Leu Ile Gly 
    210                 215                 220                 


Gln Lys Leu Gly Ile His Ser Glu Ser Cys His Gly Trp Ile Leu Gly 
225                 230                 235                 240 


Glu His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Val Asn Ile Ala 
                245                 250                 255     


Gly Val Pro Leu Lys Asp Leu Asn Ser Asp Ile Gly Thr Asp Lys Asp 
            260                 265                 270         


Pro Glu Gln Trp Lys Asn Val His Lys Glu Val Thr Ala Thr Ala Tyr 
        275                 280                 285             


Glu Ile Ile Lys Met Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser 
    290                 295                 300                 


Val Ala Asp Leu Thr Glu Ser Ile Leu Lys Asn Leu Arg Arg Ile His 
305                 310                 315                 320 


Pro Val Ser Thr Ile Ile Lys Gly Leu Tyr Gly Ile Asp Glu Glu Val 
                325                 330                 335     


Phe Leu Ser Ile Pro Cys Ile Leu Gly Glu Asn Gly Ile Thr Asn Leu 
            340                 345                 350         


Ile Lys Ile Lys Leu Thr Pro Glu Glu Glu Ala His Leu Lys Lys Ser 
        355                 360                 365             


Ala Lys Thr Leu Trp Glu Ile Gln Asn Lys Leu Lys Leu 
    370                 375                 380     


<210>  6138
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDHB__Homo_sapiens__NP_002291

<400>  6138

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


<210>  6139
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDHC__Homo_sapiens__NP_059144

<400>  6139

Met Ser Thr Val Lys Glu Gln Leu Ile Glu Lys Leu Ile Glu Asp Asp 
1               5                   10                  15      


Glu Asn Ser Gln Cys Lys Ile Thr Ile Val Gly Thr Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Leu Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ala Leu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Phe Ser Thr Ser Lys Ile Thr Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Ser Val Ser Ala Asn Ser Arg Ile Val Ile Val Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Thr Arg Leu Ala Leu Val Gln Arg 
            100                 105                 110         


Asn Val Ala Ile Met Lys Ser Ile Ile Pro Ala Ile Val His Tyr Ser 
        115                 120                 125             


Pro Asp Cys Lys Ile Leu Val Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Ile Val Trp Lys Ile Ser Gly Leu Pro Val Thr Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Ile Gly Glu 
                165                 170                 175     


Lys Leu Gly Val His Pro Thr Ser Cys His Gly Trp Ile Ile Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Leu Trp Ser Gly Val Asn Val Ala Gly 
        195                 200                 205             


Val Ala Leu Lys Thr Leu Asp Pro Lys Leu Gly Thr Asp Ser Asp Lys 
    210                 215                 220                 


Glu His Trp Lys Asn Ile His Lys Gln Val Ile Gln Ser Ala Tyr Glu 
225                 230                 235                 240 


Ile Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Met Asp Leu Val Gly Ser Ile Leu Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Val Lys Gly Leu Tyr Gly Ile Lys Glu Glu Leu Phe 
        275                 280                 285             


Leu Ser Ile Pro Cys Val Leu Gly Arg Asn Gly Val Ser Asp Val Val 
    290                 295                 300                 


Lys Ile Asn Leu Asn Ser Glu Glu Glu Ala Leu Phe Lys Lys Ser Ala 
305                 310                 315                 320 


Glu Thr Leu Trp Asn Ile Gln Lys Asp Leu Ile Phe 
                325                 330         


<210>  6140
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDHD__Homo_sapiens__NP_705690

<400>  6140

Met Ala Arg Leu Leu Arg Ser Ala Thr Trp Glu Leu Phe Pro Trp Arg 
1               5                   10                  15      


Gly Tyr Cys Ser Gln Lys Ala Lys Gly Glu Leu Cys Arg Asp Phe Val 
            20                  25                  30          


Glu Ala Leu Lys Ala Val Val Gly Gly Ser His Val Ser Thr Ala Ala 
        35                  40                  45              


Val Val Arg Glu Gln His Gly Arg Asp Glu Ser Val His Arg Cys Glu 
    50                  55                  60                  


Pro Pro Asp Ala Val Val Trp Pro Gln Asn Val Glu Gln Val Ser Arg 
65                  70                  75                  80  


Leu Ala Ala Leu Cys Tyr Arg Gln Gly Val Pro Ile Ile Pro Phe Gly 
                85                  90                  95      


Thr Gly Thr Gly Leu Glu Gly Gly Val Cys Ala Val Gln Gly Gly Val 
            100                 105                 110         


Cys Val Asn Leu Thr His Met Asp Arg Ile Leu Glu Leu Asn Gln Glu 
        115                 120                 125             


Asp Phe Ser Val Val Val Glu Pro Gly Val Thr Arg Lys Ala Leu Asn 
    130                 135                 140                 


Ala His Leu Arg Asp Ser Gly Leu Trp Phe Pro Val Asp Pro Gly Ala 
145                 150                 155                 160 


Asp Ala Ser Leu Cys Gly Met Ala Ala Thr Gly Ala Ser Gly Thr Asn 
                165                 170                 175     


Ala Val Arg Tyr Gly Thr Met Arg Asp Asn Val Leu Asn Leu Glu Val 
            180                 185                 190         


Val Leu Pro Asp Gly Arg Leu Leu His Thr Ala Gly Arg Gly Arg His 
        195                 200                 205             


Phe Arg Phe Gly Phe Trp Pro Glu Ile Pro His His Thr Ala Trp Tyr 
    210                 215                 220                 


Ser Pro Cys Val Ser Leu Gly Arg Arg Lys Ser Ala Ala Gly Tyr Asn 
225                 230                 235                 240 


Leu Thr Gly Leu Phe Val Gly Ser Glu Gly Thr Leu Gly Leu Ile Thr 
                245                 250                 255     


Ala Thr Thr Leu Arg Leu His Pro Ala Pro Glu Ala Thr Val Ala Ala 
            260                 265                 270         


Thr Cys Ala Phe Pro Ser Val Gln Ala Ala Val Asp Ser Thr Val His 
        275                 280                 285             


Ile Leu Gln Ala Ala Val Pro Val Ala Arg Ile Glu Phe Leu Asp Glu 
    290                 295                 300                 


Val Met Met Asp Ala Cys Asn Arg Tyr Ser Lys Leu Asn Cys Leu Val 
305                 310                 315                 320 


Ala Pro Thr Leu Phe Leu Glu Phe His Gly Ser Gln Gln Ala Leu Glu 
                325                 330                 335     


Glu Gln Leu Gln Arg Thr Glu Glu Ile Val Gln Gln Asn Gly Ala Ser 
            340                 345                 350         


Asp Phe Ser Trp Ala Lys Glu Ala Glu Glu Arg Ser Arg Leu Trp Thr 
        355                 360                 365             


Ala Arg His Asn Ala Trp Tyr Ala Ala Leu Ala Thr Arg Pro Gly Cys 
    370                 375                 380                 


Lys Gly Tyr Ser Thr Asp Val Cys Val Pro Ile Ser Arg Leu Pro Glu 
385                 390                 395                 400 


Ile Val Val Gln Thr Lys Glu Asp Leu Asn Ala Ser Gly Leu Thr Gly 
                405                 410                 415     


Ser Ile Val Gly His Val Gly Asp Gly Asn Phe His Cys Ile Leu Leu 
            420                 425                 430         


Val Asn Pro Asp Asp Ala Glu Glu Leu Gly Arg Val Lys Ala Phe Ala 
        435                 440                 445             


Glu Gln Leu Gly Arg Arg Ala Leu Ala Leu His Gly Thr Cys Thr Gly 
    450                 455                 460                 


Glu His Gly Ile Gly Met Gly Lys Arg Gln Leu Leu Gln Glu Glu Val 
465                 470                 475                 480 


Gly Ala Val Gly Val Glu Thr Met Arg Gln Leu Lys Ala Val Leu Asp 
                485                 490                 495     


Pro Gln Gly Leu Met Asn Pro Gly Lys Val Leu 
            500                 505         


<210>  6141
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDLRAD3__Homo_sapiens__NP_777562

<400>  6141

Met Trp Leu Leu Gly Pro Leu Cys Leu Leu Leu Ser Ser Ala Ala Glu 
1               5                   10                  15      


Ser Gln Leu Leu Pro Gly Asn Asn Phe Thr Asn Glu Cys Asn Ile Pro 
            20                  25                  30          


Gly Asn Phe Met Cys Ser Asn Gly Arg Cys Ile Pro Gly Ala Trp Gln 
        35                  40                  45              


Cys Asp Gly Leu Pro Asp Cys Phe Asp Lys Ser Asp Glu Lys Glu Cys 
    50                  55                  60                  


Pro Lys Ala Lys Ser Lys Cys Gly Pro Thr Phe Phe Pro Cys Ala Ser 
65                  70                  75                  80  


Gly Ile His Cys Ile Ile Gly Arg Phe Arg Cys Asn Gly Phe Glu Asp 
                85                  90                  95      


Cys Pro Asp Gly Ser Asp Glu Glu Asn Cys Thr Ala Asn Pro Leu Leu 
            100                 105                 110         


Cys Ser Thr Ala Arg Tyr His Cys Lys Asn Gly Leu Cys Ile Asp Lys 
        115                 120                 125             


Ser Phe Ile Cys Asp Gly Gln Asn Asn Cys Gln Asp Asn Ser Asp Glu 
    130                 135                 140                 


Glu Ser Cys Glu Ser Ser Gln Glu Pro Gly Ser Gly Gln Val Phe Val 
145                 150                 155                 160 


Thr Ser Glu Asn Gln Leu Val Tyr Tyr Pro Ser Ile Thr Tyr Ala Ile 
                165                 170                 175     


Ile Gly Ser Ser Val Ile Phe Val Leu Val Val Ala Leu Leu Ala Leu 
            180                 185                 190         


Val Leu His His Gln Arg Lys Arg Asn Asn Leu Met Thr Leu Pro Val 
        195                 200                 205             


His Arg Leu Gln His Pro Val Leu Leu Ser Arg Leu Val Val Leu Asp 
    210                 215                 220                 


His Pro His His Cys Asn Val Thr Tyr Asn Val Asn Asn Gly Ile Gln 
225                 230                 235                 240 


Tyr Val Ala Ser Gln Ala Glu Gln Asn Ala Ser Glu Val Gly Ser Pro 
                245                 250                 255     


Pro Ser Tyr Ser Glu Ala Leu Leu Asp Gln Arg Pro Ala Trp Tyr Asp 
            260                 265                 270         


Leu Pro Pro Pro Pro Tyr Ser Ser Asp Thr Glu Ser Leu Asn Gln Ala 
        275                 280                 285             


Asp Leu Pro Pro Tyr Arg Ser Arg Ser Gly Ser Ala Asn Ser Ala Ser 
    290                 295                 300                 


Ser Gln Ala Ala Ser Ser Leu Leu Ser Val Glu Asp Thr Ser His Ser 
305                 310                 315                 320 


Pro Gly Gln Pro Gly Pro Gln Glu Gly Thr Ala Glu Pro Arg Asp Ser 
                325                 330                 335     


Glu Pro Ser Gln Gly Thr Glu Glu Val 
            340                 345 


<210>  6142
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDLRAD4__Homo_sapiens__NP_001003674

<400>  6142

Met Ser Ser Asp His Leu Asn Asn Ser Thr Leu Lys Glu Ala Gln Phe 
1               5                   10                  15      


Lys Asp Leu Phe Leu Lys Lys Ala Glu Leu Glu Phe Ala Gln Ile Ile 
            20                  25                  30          


Ile Ile Val Val Val Val Thr Val Met Val Val Val Ile Val Cys Leu 
        35                  40                  45              


Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe Ile Asn Arg Pro Asn 
    50                  55                  60                  


Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln Glu Gly Cys Leu Trp 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Ala Pro Arg Leu Gly Ala Ser Glu Ile Met His 
                85                  90                  95      


Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe Ile Gln Arg 
            100                 105                 110         


Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val Gln His Glu 
        115                 120                 125             


Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro 
    130                 135                 140                 


Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln 
145                 150                 155                 160 


Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile 
                165                 170                 175     


Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly Gly Pro Cys 
            180                 185                 190         


Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys Ser Ser Asn 
        195                 200                 205             


Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Met Gly His 
    210                 215                 220                 


His Pro Gly Ala Ser Phe Leu His His Gln Arg Ser Asn Ala His Arg 
225                 230                 235                 240 


Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser Thr Ile Val 
                245                 250                 255     


Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
            260                 265                 


<210>  6143
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDLR__Homo_sapiens__NP_000518

<400>  6143

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  6144
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDOC1__Homo_sapiens__NP_036449

<400>  6144

Met Val Asp Glu Leu Val Leu Leu Leu His Ala Leu Leu Met Arg His 
1               5                   10                  15      


Arg Ala Leu Ser Ile Glu Asn Ser Gln Leu Met Glu Gln Leu Arg Leu 
            20                  25                  30          


Leu Val Cys Glu Arg Ala Ser Leu Leu Arg Gln Val Arg Pro Pro Ser 
        35                  40                  45              


Cys Pro Val Pro Phe Pro Glu Thr Phe Asn Gly Glu Ser Ser Arg Leu 
    50                  55                  60                  


Pro Glu Phe Ile Val Gln Thr Ala Ser Tyr Met Leu Val Asn Glu Asn 
65                  70                  75                  80  


Arg Phe Cys Asn Asp Ala Met Lys Val Ala Phe Leu Ile Ser Leu Leu 
                85                  90                  95      


Thr Gly Glu Ala Glu Glu Trp Val Val Pro Tyr Ile Glu Met Asp Ser 
            100                 105                 110         


Pro Ile Leu Gly Asp Tyr Arg Ala Phe Leu Asp Glu Met Lys Gln Cys 
        115                 120                 125             


Phe Gly Trp Asp Asp Asp Glu Asp Asp Asp Asp Glu Glu Glu Glu Asp 
    130                 135                 140                 


Asp Tyr 
145     


<210>  6145
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LDOC1L__Homo_sapiens__NP_115663

<400>  6145

Met Val Gln Pro Gln Thr Ser Lys Ala Glu Ser Pro Ala Leu Ala Ala 
1               5                   10                  15      


Ser Pro Asn Ala Gln Met Asp Asp Val Ile Asp Thr Leu Thr Ser Leu 
            20                  25                  30          


Arg Leu Thr Asn Ser Ala Leu Arg Arg Glu Ala Ser Thr Leu Arg Ala 
        35                  40                  45              


Glu Lys Ala Asn Leu Thr Asn Met Leu Glu Ser Val Met Ala Glu Leu 
    50                  55                  60                  


Thr Leu Leu Arg Thr Arg Ala Arg Ile Pro Gly Ala Leu Gln Ile Thr 
65                  70                  75                  80  


Pro Pro Ile Ser Ser Ile Thr Ser Asn Gly Thr Arg Pro Met Thr Thr 
                85                  90                  95      


Pro Pro Thr Ser Leu Pro Glu Pro Phe Ser Gly Asp Pro Gly Arg Leu 
            100                 105                 110         


Ala Gly Phe Leu Met Gln Met Asp Arg Phe Met Ile Phe Gln Ala Ser 
        115                 120                 125             


Arg Phe Pro Gly Glu Ala Glu Arg Val Ala Phe Leu Val Ser Arg Leu 
    130                 135                 140                 


Thr Gly Glu Ala Glu Lys Trp Ala Ile Pro His Met Gln Pro Asp Ser 
145                 150                 155                 160 


Pro Leu Arg Asn Asn Tyr Gln Gly Phe Leu Ala Glu Leu Arg Arg Thr 
                165                 170                 175     


Tyr Lys Ser Pro Leu Arg His Ala Arg Arg Ala Gln Ile Arg Lys Thr 
            180                 185                 190         


Ser Ala Ser Asn Arg Ala Val Arg Glu Arg Gln Met Leu Cys Arg Gln 
        195                 200                 205             


Leu Ala Ser Ala Gly Thr Gly Pro Cys Pro Val His Pro Ala Ser Asn 
    210                 215                 220                 


Gly Thr Ser Pro Ala Pro Ala Leu Pro Ala Arg Ala Arg Asn Leu 
225                 230                 235                 


<210>  6146
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEAP2__Homo_sapiens__NP_443203

<400>  6146

Met Trp His Leu Lys Leu Cys Ala Val Leu Met Ile Phe Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ile Asp Gly Ser Pro Ile Pro Glu Val Ser Ser Ala Lys 
            20                  25                  30          


Arg Arg Pro Arg Arg Met Thr Pro Phe Trp Arg Gly Val Ser Leu Arg 
        35                  40                  45              


Pro Ile Gly Ala Ser Cys Arg Asp Asp Ser Glu Cys Ile Thr Arg Leu 
    50                  55                  60                  


Cys Arg Lys Arg Arg Cys Ser Leu Ser Val Ala Gln Glu 
65                  70                  75          


<210>  6147
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LECT1__Homo_sapiens__NP_001011705

<400>  6147

Met Thr Glu Asn Ser Asp Lys Val Pro Ile Ala Leu Val Gly Pro Asp 
1               5                   10                  15      


Asp Val Glu Phe Cys Ser Pro Pro Ala Tyr Ala Thr Leu Thr Val Lys 
            20                  25                  30          


Pro Ser Ser Pro Ala Arg Leu Leu Lys Val Gly Ala Val Val Leu Ile 
        35                  40                  45              


Ser Gly Ala Val Leu Leu Leu Phe Gly Ala Ile Gly Ala Phe Tyr Phe 
    50                  55                  60                  


Trp Lys Gly Ser Asp Ser His Ile Tyr Asn Val His Tyr Thr Met Ser 
65                  70                  75                  80  


Ile Asn Gly Lys Leu Gln Asp Gly Ser Met Glu Ile Asp Ala Gly Asn 
                85                  90                  95      


Asn Leu Glu Thr Phe Lys Met Gly Ser Gly Ala Glu Glu Ala Ile Ala 
            100                 105                 110         


Val Asn Asp Phe Gln Asn Gly Ile Thr Gly Ile Arg Phe Ala Gly Gly 
        115                 120                 125             


Glu Lys Cys Tyr Ile Lys Ala Gln Val Lys Ala Arg Ile Pro Glu Val 
    130                 135                 140                 


Gly Ala Val Thr Lys Gln Ser Ile Ser Ser Lys Leu Glu Gly Lys Ile 
145                 150                 155                 160 


Met Pro Val Lys Tyr Glu Glu Asn Ser Leu Ile Trp Val Ala Val Asp 
                165                 170                 175     


Gln Pro Val Lys Asp Asn Ser Phe Leu Ser Ser Lys Val Leu Glu Leu 
            180                 185                 190         


Cys Gly Asp Leu Pro Ile Phe Trp Leu Lys Pro Thr Tyr Pro Lys Glu 
        195                 200                 205             


Ile Gln Arg Glu Arg Arg Glu Val Val Arg Lys Ile Val Pro Thr Thr 
    210                 215                 220                 


Thr Lys Arg Pro His Ser Gly Pro Arg Ser Asn Pro Gly Ala Gly Arg 
225                 230                 235                 240 


Leu Asn Asn Glu Thr Arg Pro Ser Val Gln Glu Asp Ser Gln Ala Phe 
                245                 250                 255     


Asn Pro Asp Asn Pro Tyr His Gln Glu Gly Glu Ser Met Thr Phe Asp 
            260                 265                 270         


Pro Arg Leu Asp His Glu Gly Ile Cys Cys Ile Glu Cys Arg Arg Ser 
        275                 280                 285             


Tyr Thr His Cys Gln Lys Ile Cys Glu Pro Leu Gly Gly Tyr Tyr Pro 
    290                 295                 300                 


Trp Pro Tyr Asn Tyr Gln Gly Cys Arg Ser Ala Cys Arg Val Ile Met 
305                 310                 315                 320 


Pro Cys Ser Trp Trp Val Ala Arg Ile Leu Gly Met Val 
                325                 330             


<210>  6148
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LECT2__Homo_sapiens__NP_002293

<400>  6148

Met Phe Ser Thr Lys Ala Leu Leu Leu Ala Gly Leu Ile Ser Thr Ala 
1               5                   10                  15      


Leu Ala Gly Pro Trp Ala Asn Ile Cys Ala Gly Lys Ser Ser Asn Glu 
            20                  25                  30          


Ile Arg Thr Cys Asp Arg His Gly Cys Gly Gln Tyr Ser Ala Gln Arg 
        35                  40                  45              


Ser Gln Arg Pro His Gln Gly Val Asp Ile Leu Cys Ser Ala Gly Ser 
    50                  55                  60                  


Thr Val Tyr Ala Pro Phe Thr Gly Met Ile Val Gly Gln Glu Lys Pro 
65                  70                  75                  80  


Tyr Gln Asn Lys Asn Ala Ile Asn Asn Gly Val Arg Ile Ser Gly Arg 
                85                  90                  95      


Gly Phe Cys Val Lys Met Phe Tyr Ile Lys Pro Ile Lys Tyr Lys Gly 
            100                 105                 110         


Pro Ile Lys Lys Gly Glu Lys Leu Gly Thr Leu Leu Pro Leu Gln Lys 
        115                 120                 125             


Val Tyr Pro Gly Ile Gln Ser His Val His Ile Glu Asn Cys Asp Ser 
    130                 135                 140                 


Ser Asp Pro Thr Ala Tyr Leu 
145                 150     


<210>  6149
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEF1__Homo_sapiens__NP_001124185

<400>  6149

Met Pro Gln Leu Ser Gly Gly Gly Gly Gly Gly Gly Gly Asp Pro Glu 
1               5                   10                  15      


Leu Cys Ala Thr Asp Glu Met Ile Pro Phe Lys Asp Glu Gly Asp Pro 
            20                  25                  30          


Gln Lys Glu Lys Ile Phe Ala Glu Ile Ser His Pro Glu Glu Glu Gly 
        35                  40                  45              


Asp Leu Ala Asp Ile Lys Ser Ser Leu Val Asn Glu Ser Glu Ile Ile 
    50                  55                  60                  


Pro Ala Ser Asn Gly His Glu Val Ala Arg Gln Ala Gln Thr Ser Gln 
65                  70                  75                  80  


Glu Pro Tyr His Asp Lys Ala Arg Glu His Pro Asp Asp Gly Lys His 
                85                  90                  95      


Pro Asp Gly Gly Leu Tyr Asn Lys Gly Pro Ser Tyr Ser Ser Tyr Ser 
            100                 105                 110         


Gly Tyr Ile Met Met Pro Asn Met Asn Asn Asp Pro Tyr Met Ser Asn 
        115                 120                 125             


Gly Ser Leu Ser Pro Pro Ile Pro Arg Thr Ser Asn Lys Val Pro Val 
    130                 135                 140                 


Val Gln Pro Ser His Ala Val His Pro Leu Thr Pro Leu Ile Thr Tyr 
145                 150                 155                 160 


Ser Asp Glu His Phe Ser Pro Gly Ser His Pro Ser His Ile Pro Ser 
                165                 170                 175     


Asp Val Asn Ser Lys Gln Gly Met Ser Arg His Pro Pro Ala Pro Asp 
            180                 185                 190         


Ile Pro Thr Phe Tyr Pro Leu Ser Pro Gly Gly Val Gly Gln Ile Thr 
        195                 200                 205             


Pro Pro Leu Gly Trp Phe Ser His His Met Ile Pro Gly Pro Pro Gly 
    210                 215                 220                 


Pro His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Gln Val 
225                 230                 235                 240 


Lys Gln Glu His Pro His Thr Asp Ser Asp Leu Met His Val Lys Pro 
                245                 250                 255     


Gln His Glu Gln Arg Lys Glu Gln Glu Pro Lys Arg Pro His Ile Lys 
            260                 265                 270         


Lys Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Asn 
        275                 280                 285             


Val Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile 
    290                 295                 300                 


Leu Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr 
305                 310                 315                 320 


Tyr Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro 
                325                 330                 335     


Gly Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg 
            340                 345                 350         


Glu Lys Leu Gln Glu Ser Ala Ser Gly Thr Gly Pro Arg Met Thr Ala 
        355                 360                 365             


Ala Tyr Ile 
    370     


<210>  6150
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEFTY1__Homo_sapiens__NP_066277

<400>  6150

Met Gln Pro Leu Trp Leu Cys Trp Ala Leu Trp Val Leu Pro Leu Ala 
1               5                   10                  15      


Ser Pro Gly Ala Ala Leu Thr Gly Glu Gln Leu Leu Gly Ser Leu Leu 
            20                  25                  30          


Arg Gln Leu Gln Leu Lys Glu Val Pro Thr Leu Asp Arg Ala Asp Met 
        35                  40                  45              


Glu Glu Leu Val Ile Pro Thr His Val Arg Ala Gln Tyr Val Ala Leu 
    50                  55                  60                  


Leu Gln Arg Ser His Gly Asp Arg Ser Arg Gly Lys Arg Phe Ser Gln 
65                  70                  75                  80  


Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala Leu Glu Ala Ser Thr 
                85                  90                  95      


His Leu Leu Val Phe Gly Met Glu Gln Arg Leu Pro Pro Asn Ser Glu 
            100                 105                 110         


Leu Val Gln Ala Val Leu Arg Leu Phe Gln Glu Pro Val Pro Lys Ala 
        115                 120                 125             


Ala Leu His Arg His Gly Arg Leu Ser Pro Arg Ser Ala Arg Ala Arg 
    130                 135                 140                 


Val Thr Val Glu Trp Leu Arg Val Arg Asp Asp Gly Ser Asn Arg Thr 
145                 150                 155                 160 


Ser Leu Ile Asp Ser Arg Leu Val Ser Val His Glu Ser Gly Trp Lys 
                165                 170                 175     


Ala Phe Asp Val Thr Glu Ala Val Asn Phe Trp Gln Gln Leu Ser Arg 
            180                 185                 190         


Pro Arg Gln Pro Leu Leu Leu Gln Val Ser Val Gln Arg Glu His Leu 
        195                 200                 205             


Gly Pro Leu Ala Ser Gly Ala His Lys Leu Val Arg Phe Ala Ser Gln 
    210                 215                 220                 


Gly Ala Pro Ala Gly Leu Gly Glu Pro Gln Leu Glu Leu His Thr Leu 
225                 230                 235                 240 


Asp Leu Gly Asp Tyr Gly Ala Gln Gly Asp Cys Asp Pro Glu Ala Pro 
                245                 250                 255     


Met Thr Glu Gly Thr Arg Cys Cys Arg Gln Glu Met Tyr Ile Asp Leu 
            260                 265                 270         


Gln Gly Met Lys Trp Ala Glu Asn Trp Val Leu Glu Pro Pro Gly Phe 
        275                 280                 285             


Leu Ala Tyr Glu Cys Val Gly Thr Cys Arg Gln Pro Pro Glu Ala Leu 
    290                 295                 300                 


Ala Phe Lys Trp Pro Phe Leu Gly Pro Arg Gln Cys Ile Ala Ser Glu 
305                 310                 315                 320 


Thr Asp Ser Leu Pro Met Ile Val Ser Ile Lys Glu Gly Gly Arg Thr 
                325                 330                 335     


Arg Pro Gln Val Val Ser Leu Pro Asn Met Arg Val Gln Lys Cys Ser 
            340                 345                 350         


Cys Ala Ser Asp Gly Ala Leu Val Pro Arg Arg Leu Gln Pro 
        355                 360                 365     


<210>  6151
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEFTY2__Homo_sapiens__NP_001165896

<400>  6151

Met Trp Pro Leu Trp Leu Cys Trp Ala Leu Trp Val Leu Pro Leu Ala 
1               5                   10                  15      


Gly Pro Gly Ala Ala Leu Thr Glu Glu Gln Leu Leu Gly Ser Leu Leu 
            20                  25                  30          


Arg Gln Leu Gln Leu Ser Glu Val Pro Val Leu Asp Arg Ala Asp Met 
        35                  40                  45              


Glu Lys Leu Val Ile Pro Ala His Val Arg Ala Gln Tyr Val Val Leu 
    50                  55                  60                  


Leu Arg Arg Ser His Gly Asp Arg Ser Arg Gly Lys Arg Phe Ser Gln 
65                  70                  75                  80  


Ser Phe Arg Glu Val Ala Gly Arg Phe Leu Ala Ser Glu Ala Ala Leu 
                85                  90                  95      


His Arg His Gly Arg Leu Ser Pro Arg Ser Ala Gln Ala Arg Val Thr 
            100                 105                 110         


Val Glu Trp Leu Arg Val Arg Asp Asp Gly Ser Asn Arg Thr Ser Leu 
        115                 120                 125             


Ile Asp Ser Arg Leu Val Ser Val His Glu Ser Gly Trp Lys Ala Phe 
    130                 135                 140                 


Asp Val Thr Glu Ala Val Asn Phe Trp Gln Gln Leu Ser Arg Pro Arg 
145                 150                 155                 160 


Gln Pro Leu Leu Leu Gln Val Ser Val Gln Arg Glu His Leu Gly Pro 
                165                 170                 175     


Leu Ala Ser Gly Ala His Lys Leu Val Arg Phe Ala Ser Gln Gly Ala 
            180                 185                 190         


Pro Ala Gly Leu Gly Glu Pro Gln Leu Glu Leu His Thr Leu Asp Leu 
        195                 200                 205             


Arg Asp Tyr Gly Ala Gln Gly Asp Cys Asp Pro Glu Ala Pro Met Thr 
    210                 215                 220                 


Glu Gly Thr Arg Cys Cys Arg Gln Glu Met Tyr Ile Asp Leu Gln Gly 
225                 230                 235                 240 


Met Lys Trp Ala Lys Asn Trp Val Leu Glu Pro Pro Gly Phe Leu Ala 
                245                 250                 255     


Tyr Glu Cys Val Gly Thr Cys Gln Gln Pro Pro Glu Ala Leu Ala Phe 
            260                 265                 270         


Asn Trp Pro Phe Leu Gly Pro Arg Gln Cys Ile Ala Ser Glu Thr Ala 
        275                 280                 285             


Ser Leu Pro Met Ile Val Ser Ile Lys Glu Gly Gly Arg Thr Arg Pro 
    290                 295                 300                 


Gln Val Val Ser Leu Pro Asn Met Arg Val Gln Lys Cys Ser Cys Ala 
305                 310                 315                 320 


Ser Asp Gly Ala Leu Val Pro Arg Arg Leu Gln Pro 
                325                 330         


<210>  6152
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEKR1__Homo_sapiens__NP_001004316

<400>  6152

Met Asp His His Ile Pro Met His Ala Leu Pro Glu Glu Ile Gln Lys 
1               5                   10                  15      


Met Leu Pro Glu Glu Lys Val Cys Lys Tyr Cys Gly Val Ser Tyr Leu 
            20                  25                  30          


Ile Leu His Glu Phe Lys Ala Met Glu Glu Lys Val Lys Ala Met Glu 
        35                  40                  45              


Lys Glu Met Lys Phe Tyr Gln Gly Ser Val Asp Arg Glu Lys Arg Leu 
    50                  55                  60                  


Gln Glu Lys Leu His Ser Leu Ser Gln Glu Leu Glu Gln Tyr Lys Ile 
65                  70                  75                  80  


Asp Asn Lys Ser Lys Thr Glu Arg Ile Tyr Asp Val Gly Met Gln Leu 
                85                  90                  95      


Lys Ser Gln Gln Asn Glu Phe Gln Lys Val Lys Lys Gln Leu Ser His 
            100                 105                 110         


Leu Gln Asp Glu Leu Lys Ile Lys Tyr Arg Gln Ser Tyr Ile Phe Ser 
        115                 120                 125             


Gln Arg Leu Ser Glu Tyr Lys Tyr Phe Trp Asn Lys Thr Leu Ser Leu 
    130                 135                 140                 


Leu Thr Phe Thr Lys Arg Glu Leu Thr Ser Ile Lys Asn Glu Val Tyr 
145                 150                 155                 160 


Asp Asn Tyr Gln Asn Trp Thr Ser Leu Lys Gly Ala Val Phe Leu Gln 
                165                 170                 175     


Ile Lys Ser Ile Ser Glu Thr Ala Leu Thr Glu Ile Asp Ile Leu Asn 
            180                 185                 190         


Lys Ser Leu Thr Val Ser Gln Arg Asn Lys Val Cys Leu Glu Lys Glu 
        195                 200                 205             


Met Lys Asn Leu Lys Leu Leu Ser Asp Ala Ala Ile Leu Arg Ser Gln 
    210                 215                 220                 


Gln Ile Arg Thr Ser Arg Gln Gln Glu Val Asn Leu Gln Thr Arg Cys 
225                 230                 235                 240 


Tyr Asp Leu Gln Lys Glu Val Leu Asp Leu Gln Cys Leu Val Glu Ala 
                245                 250                 255     


Leu Gly Leu Lys Leu Gln Lys Ala Val Thr Glu Met Asp Asn Tyr Lys 
            260                 265                 270         


Glu Met Leu Met Asn Lys Ser Asn Glu Ala Asp Asp Cys Gln Arg Glu 
        275                 280                 285             


Leu Lys Lys Leu Lys Phe Glu Ser Ile Ile Ser Glu Ser Gln His Thr 
    290                 295                 300                 


Met Leu Leu Lys Glu Lys Glu Asp Ser Leu Met Thr Cys Gln Gln Ile 
305                 310                 315                 320 


Tyr Lys Ala Leu Gln Glu Glu Leu Thr Val Lys Glu Lys Gln Glu Glu 
                325                 330                 335     


Asp Ile Lys Arg Arg Ile Asn Leu Ala Glu Asn Glu Leu Glu Ile Thr 
            340                 345                 350         


Lys Thr Leu Leu Asn Gln Thr Arg Glu Glu Val Leu Thr Leu Lys Asn 
        355                 360                 365             


Glu Arg Glu Leu Met Leu Ile Ser His Gln Lys Ser Ile Glu Gln Leu 
    370                 375                 380                 


Gln Glu Thr Leu Arg Gln Lys Leu Leu Ser Asp Asp Asn Trp Lys Glu 
385                 390                 395                 400 


Lys Ile Glu Ala Glu Leu Ala Lys Glu Arg Ala Gln His Leu Val Glu 
                405                 410                 415     


Phe Glu Glu Gln Ala Leu Leu Phe Lys Glu Glu Thr Lys Leu Gln Leu 
            420                 425                 430         


Asp Ile Glu Lys Glu Lys His Gln Asp Val Ile Gln Lys Tyr Lys Lys 
        435                 440                 445             


Glu Gln Glu Glu Leu Gln Met Lys Ile Ser Asp Leu Ile Thr Gly Ala 
    450                 455                 460                 


Thr Arg Asp Leu Arg Gln Glu Val Thr Thr Leu Lys Glu Lys Leu His 
465                 470                 475                 480 


Lys Ser His Ile Arg Tyr Thr Glu Glu Ser Asn Ser Lys Glu Lys Glu 
                485                 490                 495     


Ile Glu Asn Leu Lys Asn Leu Val Ala Glu Phe Glu Ser Arg Leu Lys 
            500                 505                 510         


Lys Glu Ile Asp Ser Asn Asp Ser Val Ser Glu Asn Leu Arg Lys Glu 
        515                 520                 525             


Met Glu Gln Lys Ser Asp Glu Leu Lys Arg Val Met Leu Ala Gln Thr 
    530                 535                 540                 


Gln Leu Ile Glu Gln Phe Asn Gln Ser Gln Glu Glu Asn Thr Phe Leu 
545                 550                 555                 560 


Gln Glu Thr Val Arg Arg Glu Cys Glu Glu Arg Phe Glu Leu Thr Glu 
                565                 570                 575     


Ala Leu Ser Gln Ala Arg Glu Gln Leu Leu Glu Leu Ser Lys Leu Arg 
            580                 585                 590         


Gly Ser Leu Pro Phe Ser Pro Cys Ser Leu Ser Lys Gly Ser Leu Thr 
        595                 600                 605             


Ser Pro Ala Ala Ala Val Ser Asn His Gly Glu Arg Ser Leu Ala Arg 
    610                 615                 620                 


Leu Asn Ser Glu Lys Gly Ile Gln Ile Pro Asn Leu Arg Gly Val Ser 
625                 630                 635                 640 


Lys Pro Thr Thr Phe Pro Thr Ser Asp Lys Pro Lys Arg Val Arg Ser 
                645                 650                 655     


Gly Val Pro Ile Leu Pro Gln Pro His Pro Pro Arg Gly Gly Ala Ser 
            660                 665                 670         


Ser Ala Asn Glu Thr Arg Gln Arg Leu Ala Ala Ile Leu Arg Arg Arg 
        675                 680                 685             


Arg Ser Gln Gln 
    690         


<210>  6153
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEMD2__Homo_sapiens__NP_001137416

<400>  6153

Met Glu Ala Gln Glu Tyr Ile Ala Asn Val Thr Ser Ser Ser Ser Ala 
1               5                   10                  15      


Lys Phe Glu Ala Ala Leu Thr Trp Ile Leu Ser Ser Asn Lys Asp Val 
            20                  25                  30          


Gly Ile Trp Leu Lys Gly Glu Asp Gln Ser Glu Leu Val Thr Thr Val 
        35                  40                  45              


Asp Lys Val Val Cys Leu Glu Ser Ala His Pro Arg Met Gly Val Gly 
    50                  55                  60                  


Cys Arg Leu Ser Arg Ala Leu Leu Thr Ala Val Thr Asn Val Leu Ile 
65                  70                  75                  80  


Phe Phe Trp Cys Leu Ala Phe Leu Trp Gly Leu Leu Ile Leu Leu Lys 
                85                  90                  95      


Tyr Arg Trp Arg Lys Leu Glu Glu Glu Glu Gln Ala Met Tyr Glu Met 
            100                 105                 110         


Val Lys Lys Ile Ile Asp Val Val Gln Asp His Tyr Val Asp Trp Glu 
        115                 120                 125             


Gln Asp Met Glu Arg Tyr Pro Tyr Val Gly Ile Leu His Val Arg Asp 
    130                 135                 140                 


Ser Leu Ile Pro Pro Gln Ser Arg Arg Arg Met Lys Arg Val Trp Asp 
145                 150                 155                 160 


Arg Ala Val Glu Phe Leu Ala Ser Asn Glu Ser Arg Ile Gln Thr Glu 
                165                 170                 175     


Ser His Arg Val Ala Gly Glu Asp Met Leu Val Trp Arg Trp Thr Lys 
            180                 185                 190         


Pro Ser Ser Phe Ser Asp Ser Glu Arg 
        195                 200     


<210>  6154
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEMD3__Homo_sapiens__NP_055134

<400>  6154

Met Ala Ala Ala Ala Ala Ser Ala Pro Gln Gln Leu Ser Asp Glu Glu 
1               5                   10                  15      


Leu Phe Ser Gln Leu Arg Arg Tyr Gly Leu Ser Pro Gly Pro Val Thr 
            20                  25                  30          


Glu Ser Thr Arg Pro Val Tyr Leu Lys Lys Leu Lys Lys Leu Arg Glu 
        35                  40                  45              


Glu Glu Gln Gln Gln His Arg Ser Gly Gly Arg Gly Asn Lys Thr Arg 
    50                  55                  60                  


Asn Ser Asn Asn Asn Asn Thr Ala Ala Ala Thr Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Ala Ala Ala Ala Ala Ala Gly Met Gly Val Arg Pro Val Ser Gly 
                85                  90                  95      


Asp Leu Ser Tyr Leu Arg Thr Pro Gly Gly Leu Cys Arg Ile Ser Ala 
            100                 105                 110         


Ser Gly Pro Glu Ser Leu Leu Gly Gly Pro Gly Gly Ala Ser Ala Ala 
        115                 120                 125             


Pro Ala Ala Gly Ser Lys Val Leu Leu Gly Phe Ser Ser Asp Glu Ser 
    130                 135                 140                 


Asp Val Glu Ala Ser Pro Arg Asp Gln Ala Gly Gly Gly Gly Arg Lys 
145                 150                 155                 160 


Asp Arg Ala Ser Leu Gln Tyr Arg Gly Leu Lys Ala Pro Pro Ala Pro 
                165                 170                 175     


Leu Ala Ala Ser Glu Val Thr Asn Ser Asn Ser Ala Glu Arg Arg Lys 
            180                 185                 190         


Pro His Ser Trp Trp Gly Ala Arg Arg Pro Ala Gly Pro Glu Leu Gln 
        195                 200                 205             


Thr Pro Pro Gly Lys Asp Gly Ala Val Glu Asp Glu Glu Gly Glu Gly 
    210                 215                 220                 


Glu Asp Gly Glu Glu Arg Asp Pro Glu Thr Glu Glu Pro Leu Trp Ala 
225                 230                 235                 240 


Ser Arg Thr Val Asn Gly Ser Arg Leu Val Pro Tyr Ser Cys Arg Glu 
                245                 250                 255     


Asn Tyr Ser Asp Ser Glu Glu Glu Asp Asp Asp Asp Val Ala Ser Ser 
            260                 265                 270         


Arg Gln Val Leu Lys Asp Asp Ser Leu Ser Arg His Arg Pro Arg Arg 
        275                 280                 285             


Thr His Ser Lys Pro Leu Pro Pro Leu Thr Ala Lys Ser Ala Gly Gly 
    290                 295                 300                 


Arg Leu Glu Thr Ser Val Gln Gly Gly Gly Gly Leu Ala Met Asn Asp 
305                 310                 315                 320 


Arg Ala Ala Ala Ala Gly Ser Leu Asp Arg Ser Arg Asn Leu Glu Glu 
                325                 330                 335     


Ala Ala Ala Ala Glu Gln Gly Gly Gly Cys Asp Gln Val Asp Ser Ser 
            340                 345                 350         


Pro Val Pro Arg Tyr Arg Val Asn Ala Lys Lys Leu Thr Pro Leu Leu 
        355                 360                 365             


Pro Pro Pro Leu Thr Asp Met Asp Ser Thr Leu Asp Ser Ser Thr Gly 
    370                 375                 380                 


Ser Leu Leu Lys Thr Asn Asn His Ile Gly Gly Gly Ala Phe Ser Val 
385                 390                 395                 400 


Asp Ser Pro Arg Ile Tyr Ser Asn Ser Leu Pro Pro Ser Ala Ala Val 
                405                 410                 415     


Ala Ala Ser Ser Ser Leu Arg Ile Asn His Ala Asn His Thr Gly Ser 
            420                 425                 430         


Asn His Thr Tyr Leu Lys Asn Thr Tyr Asn Lys Pro Lys Leu Ser Glu 
        435                 440                 445             


Pro Glu Glu Glu Leu Leu Gln Gln Phe Lys Arg Glu Glu Val Ser Pro 
    450                 455                 460                 


Thr Gly Ser Phe Ser Ala His Tyr Leu Ser Met Phe Leu Leu Thr Ala 
465                 470                 475                 480 


Ala Cys Leu Phe Phe Leu Ile Leu Gly Leu Thr Tyr Leu Gly Met Arg 
                485                 490                 495     


Gly Thr Gly Val Ser Glu Asp Gly Glu Leu Ser Ile Glu Asn Pro Phe 
            500                 505                 510         


Gly Glu Thr Phe Gly Lys Ile Gln Glu Ser Glu Lys Thr Leu Met Met 
        515                 520                 525             


Asn Thr Leu Tyr Lys Leu His Asp Arg Leu Ala Gln Leu Ala Gly Asp 
    530                 535                 540                 


His Glu Cys Gly Ser Ser Ser Gln Arg Thr Leu Ser Val Gln Glu Ala 
545                 550                 555                 560 


Ala Ala Tyr Leu Lys Asp Leu Gly Pro Glu Tyr Glu Gly Ile Phe Asn 
                565                 570                 575     


Thr Ser Leu Gln Trp Ile Leu Glu Asn Gly Lys Asp Val Gly Ile Arg 
            580                 585                 590         


Cys Val Gly Phe Gly Pro Glu Glu Glu Leu Thr Asn Ile Thr Asp Val 
        595                 600                 605             


Gln Phe Leu Gln Ser Thr Arg Pro Leu Met Ser Phe Trp Cys Arg Phe 
    610                 615                 620                 


Arg Arg Ala Phe Val Thr Val Thr His Arg Leu Leu Leu Leu Cys Leu 
625                 630                 635                 640 


Gly Val Val Met Val Cys Val Val Leu Arg Tyr Met Lys Tyr Arg Trp 
                645                 650                 655     


Thr Lys Glu Glu Glu Glu Thr Arg Gln Met Tyr Asp Met Val Val Lys 
            660                 665                 670         


Ile Ile Asp Val Leu Arg Ser His Asn Glu Ala Cys Gln Glu Asn Lys 
        675                 680                 685             


Asp Leu Gln Pro Tyr Met Pro Ile Pro His Val Arg Asp Ser Leu Ile 
    690                 695                 700                 


Gln Pro His Asp Arg Lys Lys Met Lys Lys Val Trp Asp Arg Ala Val 
705                 710                 715                 720 


Asp Phe Leu Ala Ala Asn Glu Ser Arg Val Arg Thr Glu Thr Arg Arg 
                725                 730                 735     


Ile Gly Gly Ala Asp Phe Leu Val Trp Arg Trp Ile Gln Pro Ser Ala 
            740                 745                 750         


Ser Cys Asp Lys Ile Leu Val Ile Pro Ser Lys Val Trp Gln Gly Gln 
        755                 760                 765             


Ala Phe His Leu Asp Arg Arg Asn Ser Pro Pro Asn Ser Leu Thr Pro 
    770                 775                 780                 


Cys Leu Lys Ile Arg Asn Met Phe Asp Pro Val Met Glu Ile Gly Asp 
785                 790                 795                 800 


Gln Trp His Leu Ala Ile Gln Glu Ala Ile Leu Glu Lys Cys Ser Asp 
                805                 810                 815     


Asn Asp Gly Ile Val His Ile Ala Val Asp Lys Asn Ser Arg Glu Gly 
            820                 825                 830         


Cys Val Tyr Val Lys Cys Leu Ser Pro Glu Tyr Ala Gly Lys Ala Phe 
        835                 840                 845             


Lys Ala Leu His Gly Ser Trp Phe Asp Gly Lys Leu Val Thr Val Lys 
    850                 855                 860                 


Tyr Leu Arg Leu Asp Arg Tyr His His Arg Phe Pro Gln Ala Leu Thr 
865                 870                 875                 880 


Ser Asn Thr Pro Leu Lys Pro Ser Asn Lys His Met Asn Ser Met Ser 
                885                 890                 895     


His Leu Arg Leu Arg Thr Gly Leu Thr Asn Ser Gln Gly Ser Ser 
            900                 905                 910     


<210>  6155
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEO1__Homo_sapiens__NP_001273359

<400>  6155

Met Ala Asp Met Glu Asp Leu Phe Gly Ser Asp Ala Asp Ser Glu Ala 
1               5                   10                  15      


Glu Arg Lys Asp Ser Asp Ser Gly Ser Asp Ser Asp Ser Asp Gln Glu 
            20                  25                  30          


Asn Ala Ala Ser Gly Ser Asn Ala Ser Gly Ser Glu Ser Asp Gln Asp 
        35                  40                  45              


Glu Arg Gly Asp Ser Gly Gln Pro Ser Asn Lys Glu Leu Phe Gly Asp 
    50                  55                  60                  


Asp Ser Glu Asp Glu Gly Ala Ser His His Ser Gly Ser Asp Asn His 
65                  70                  75                  80  


Ser Glu Arg Ser Asp Asn Arg Ser Glu Ala Ser Glu Arg Ser Asp His 
                85                  90                  95      


Glu Asp Asn Asp Pro Ser Asp Val Asp Gln His Ser Gly Ser Glu Ala 
            100                 105                 110         


Pro Asn Asp Asp Glu Asp Glu Gly His Arg Ser Asp Gly Gly Ser His 
        115                 120                 125             


His Ser Glu Ala Glu Gly Ser Glu Lys Ala His Ser Asp Asp Glu Lys 
    130                 135                 140                 


Trp Gly Arg Glu Asp Lys Ser Asp Gln Ser Asp Asp Glu Lys Ile Gln 
145                 150                 155                 160 


Asn Ser Asp Asp Glu Glu Arg Ala Gln Gly Ser Asp Glu Asp Lys Leu 
                165                 170                 175     


Gln Asn Ser Asp Asp Asp Glu Lys Met Gln Asn Thr Asp Asp Glu Glu 
            180                 185                 190         


Arg Pro Gln Leu Ser Asp Asp Glu Arg Gln Gln Leu Ser Glu Glu Glu 
        195                 200                 205             


Lys Ala Asn Ser Asp Asp Glu Arg Pro Val Ala Ser Asp Asn Asp Asp 
    210                 215                 220                 


Glu Lys Gln Asn Ser Asp Asp Glu Glu Gln Pro Gln Leu Ser Asp Glu 
225                 230                 235                 240 


Glu Lys Met Gln Asn Ser Asp Asp Glu Arg Pro Gln Ala Ser Asp Glu 
                245                 250                 255     


Glu His Arg His Ser Asp Asp Glu Glu Glu Gln Asp His Lys Ser Glu 
            260                 265                 270         


Ser Ala Arg Gly Ser Asp Ser Glu Asp Glu Val Leu Arg Met Lys Arg 
        275                 280                 285             


Lys Asn Ala Ile Ala Ser Asp Ser Glu Ala Asp Ser Asp Thr Glu Val 
    290                 295                 300                 


Pro Lys Asp Asn Ser Gly Thr Met Asp Leu Phe Gly Gly Ala Asp Asp 
305                 310                 315                 320 


Ile Ser Ser Gly Ser Asp Gly Glu Asp Lys Pro Pro Thr Pro Gly Gln 
                325                 330                 335     


Pro Val Asp Glu Asn Gly Leu Pro Gln Asp Gln Gln Glu Glu Glu Pro 
            340                 345                 350         


Ile Pro Glu Thr Arg Ile Glu Val Glu Ile Pro Lys Val Asn Thr Asp 
        355                 360                 365             


Leu Gly Asn Asp Leu Tyr Phe Val Lys Leu Pro Asn Phe Leu Ser Val 
    370                 375                 380                 


Glu Pro Ser Met Ser Leu His Leu Gly Asn Glu Val Phe Asp Val Tyr 
385                 390                 395                 400 


Lys Ala Pro Leu Gln Gly Asp His Asn His Leu Phe Ile Arg Gln Gly 
                405                 410                 415     


Thr Gly Leu Gln Gly Gln Ala Val Phe Lys Thr Lys Leu Thr Phe Arg 
            420                 425                 430         


Pro His Ser Thr Asp Ser Ala Thr His Arg Lys Met Thr Leu Ser Leu 
        435                 440                 445             


Ala Asp Arg Cys Ser Lys Thr Gln Lys Ile Arg Ile Leu Pro Met Ala 
    450                 455                 460                 


Gly Arg Asp Pro Glu Cys Gln Arg Thr Glu Met Ile Lys Lys Glu Glu 
465                 470                 475                 480 


Glu Arg Leu Arg Ala Ser Ile Arg Arg Glu Ser Gln Gln Arg Arg Met 
                485                 490                 495     


Arg Glu Lys Gln His Gln Arg Gly Leu Ser Ala Ser Tyr Leu Glu Pro 
            500                 505                 510         


Asp Arg Tyr Asp Glu Glu Glu Glu Gly Glu Glu Ser Ile Ser Leu Ala 
        515                 520                 525             


Ala Ile Lys Asn Arg Tyr Lys Gly Gly Ile Arg Glu Glu Arg Ala Arg 
    530                 535                 540                 


Ile Tyr Ser Ser Asp Ser Asp Glu Gly Ser Glu Glu Asp Lys Ala Gln 
545                 550                 555                 560 


Arg Leu Leu Lys Ala Lys Lys Leu Thr Ser Asp Glu Glu Gly Glu Pro 
                565                 570                 575     


Ser Gly Lys Arg Lys Ala Glu Asp Asp Asp Lys Ala Asn Lys Lys His 
            580                 585                 590         


Lys Lys Tyr Val Ile Ser Asp Glu Glu Glu Glu Asp Asp Asp 
        595                 600                 605     


<210>  6156
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEP__Homo_sapiens__NP_000221

<400>  6156

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  6157
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEPROTL1__Homo_sapiens__NP_001121680

<400>  6157

Met Ala Gly Ile Lys Ala Leu Ile Ser Leu Ser Phe Gly Gly Ala Ile 
1               5                   10                  15      


Gly Leu Met Phe Leu Met Leu Gly Cys Ala Leu Pro Ile Tyr Asn Lys 
            20                  25                  30          


Tyr Trp Pro Leu Phe Val Leu Phe Phe Tyr Ile Leu Ser Pro Ile Pro 
        35                  40                  45              


Tyr Cys Ile Ala Arg Arg Leu Val Asp Asp Thr Asp Ala Met Ser Asn 
    50                  55                  60                  


Ala Cys Lys Glu Leu Ala Ile Phe Leu Thr Thr Gly Ile Val Val Ser 
65                  70                  75                  80  


Ala Phe Gly Leu Pro Ile Val Phe Ala Arg Ala His Leu Met Gly Arg 
                85                  90                  95      


Leu Pro Phe Phe Ser Lys Met Gly Thr Ala Glu Ser Glu Gly Arg Glu 
            100                 105                 110         


Thr Leu Thr Gln Gln Leu Pro Leu Pro Ala Ala Ala Met Arg Arg Leu 
        115                 120                 125             


Leu Pro Ala Ser Arg Val Ser Thr Gln Pro Val Leu Arg Leu Ala Asp 
    130                 135                 140                 


Ser Ala Glu Ser Leu Leu Gly Arg Pro Ala Leu Trp Ala Leu Gly Phe 
145                 150                 155                 160 


Leu Leu Cys Pro Pro Ser Gln Ala Gln 
                165                 


<210>  6158
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LETM1__Homo_sapiens__NP_036450

<400>  6158

Met Ala Ser Ile Leu Leu Arg Ser Cys Arg Gly Arg Ala Pro Ala Arg 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Tyr Thr Val Pro Arg Gly Ser Pro Gly Asp 
            20                  25                  30          


Pro Ala His Leu Ser Cys Ala Ser Thr Leu Gly Leu Arg Asn Cys Leu 
        35                  40                  45              


Asn Val Pro Phe Gly Cys Cys Thr Pro Ile His Pro Val Tyr Thr Ser 
    50                  55                  60                  


Ser Arg Gly Asp His Leu Gly Cys Trp Ala Leu Arg Pro Glu Cys Leu 
65                  70                  75                  80  


Arg Ile Val Ser Arg Ala Pro Trp Thr Ser Thr Ser Val Gly Phe Val 
                85                  90                  95      


Ala Val Gly Pro Gln Cys Leu Pro Val Arg Gly Trp His Ser Ser Arg 
            100                 105                 110         


Pro Val Arg Asp Asp Ser Val Val Glu Lys Ser Leu Lys Ser Leu Lys 
        115                 120                 125             


Asp Lys Asn Lys Lys Leu Glu Glu Gly Gly Pro Val Tyr Ser Pro Pro 
    130                 135                 140                 


Ala Glu Val Val Val Lys Lys Ser Leu Gly Gln Arg Val Leu Asp Glu 
145                 150                 155                 160 


Leu Lys His Tyr Tyr His Gly Phe Arg Leu Leu Trp Ile Asp Thr Lys 
                165                 170                 175     


Ile Ala Ala Arg Met Leu Trp Arg Ile Leu Asn Gly His Ser Leu Thr 
            180                 185                 190         


Arg Arg Glu Arg Arg Gln Phe Leu Arg Ile Cys Ala Asp Leu Phe Arg 
        195                 200                 205             


Leu Val Pro Phe Leu Val Phe Val Val Val Pro Phe Met Glu Phe Leu 
    210                 215                 220                 


Leu Pro Val Ala Val Lys Leu Phe Pro Asn Met Leu Pro Ser Thr Phe 
225                 230                 235                 240 


Glu Thr Gln Ser Leu Lys Glu Glu Arg Leu Lys Lys Glu Leu Arg Val 
                245                 250                 255     


Lys Leu Glu Leu Ala Lys Phe Leu Gln Asp Thr Ile Glu Glu Met Ala 
            260                 265                 270         


Leu Lys Asn Lys Ala Ala Lys Gly Ser Ala Thr Lys Asp Phe Ser Val 
        275                 280                 285             


Phe Phe Gln Lys Ile Arg Glu Thr Gly Glu Arg Pro Ser Asn Glu Glu 
    290                 295                 300                 


Ile Met Arg Phe Ser Lys Leu Phe Glu Asp Glu Leu Thr Leu Asp Asn 
305                 310                 315                 320 


Leu Thr Arg Pro Gln Leu Val Ala Leu Cys Lys Leu Leu Glu Leu Gln 
                325                 330                 335     


Ser Ile Gly Thr Asn Asn Phe Leu Arg Phe Gln Leu Thr Met Arg Leu 
            340                 345                 350         


Arg Ser Ile Lys Ala Asp Asp Lys Leu Ile Ala Glu Glu Gly Val Asp 
        355                 360                 365             


Ser Leu Asn Val Lys Glu Leu Gln Ala Ala Cys Arg Ala Arg Gly Met 
    370                 375                 380                 


Arg Ala Leu Gly Val Thr Glu Asp Arg Leu Arg Gly Gln Leu Lys Gln 
385                 390                 395                 400 


Trp Leu Asp Leu His Leu His Gln Glu Ile Pro Thr Ser Leu Leu Ile 
                405                 410                 415     


Leu Ser Arg Ala Met Tyr Leu Pro Asp Thr Leu Ser Pro Ala Asp Gln 
            420                 425                 430         


Leu Lys Ser Thr Leu Gln Thr Leu Pro Glu Ile Val Ala Lys Glu Ala 
        435                 440                 445             


Gln Val Lys Val Ala Glu Val Glu Gly Glu Gln Val Asp Asn Lys Ala 
    450                 455                 460                 


Lys Leu Glu Ala Thr Leu Gln Glu Glu Ala Ala Ile Gln Gln Glu His 
465                 470                 475                 480 


Arg Glu Lys Glu Leu Gln Lys Arg Ser Glu Val Ala Lys Asp Phe Glu 
                485                 490                 495     


Pro Glu Arg Val Val Ala Ala Pro Gln Arg Pro Gly Thr Glu Pro Gln 
            500                 505                 510         


Pro Glu Met Pro Asp Thr Val Leu Gln Ser Glu Thr Leu Lys Asp Thr 
        515                 520                 525             


Ala Pro Val Leu Glu Gly Leu Lys Glu Glu Glu Ile Thr Lys Glu Glu 
    530                 535                 540                 


Ile Asp Ile Leu Ser Asp Ala Cys Ser Lys Leu Gln Glu Gln Lys Lys 
545                 550                 555                 560 


Ser Leu Thr Lys Glu Lys Glu Glu Leu Glu Leu Leu Lys Glu Asp Val 
                565                 570                 575     


Gln Asp Tyr Ser Glu Asp Leu Gln Glu Ile Lys Lys Glu Leu Ser Lys 
            580                 585                 590         


Thr Gly Glu Glu Lys Tyr Val Glu Glu Ser Lys Ala Ser Lys Arg Leu 
        595                 600                 605             


Thr Lys Arg Val Gln Gln Met Ile Gly Gln Ile Asp Gly Leu Ile Ser 
    610                 615                 620                 


Gln Leu Glu Met Asp Gln Gln Ala Gly Lys Leu Ala Pro Ala Asn Gly 
625                 630                 635                 640 


Met Pro Thr Gly Glu Asn Val Ile Ser Val Ala Glu Leu Ile Asn Ala 
                645                 650                 655     


Met Lys Gln Val Lys His Ile Pro Glu Ser Lys Leu Thr Ser Leu Ala 
            660                 665                 670         


Ala Ala Leu Asp Glu Asn Lys Asp Gly Lys Val Asn Ile Asp Asp Leu 
        675                 680                 685             


Val Lys Val Ile Glu Leu Val Asp Lys Glu Asp Val His Ile Ser Thr 
    690                 695                 700                 


Ser Gln Val Ala Glu Ile Val Ala Thr Leu Glu Lys Glu Glu Lys Val 
705                 710                 715                 720 


Glu Glu Lys Glu Lys Ala Lys Glu Lys Ala Glu Lys Glu Val Ala Glu 
                725                 730                 735     


Val Lys Ser 
            


<210>  6159
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LETMD1__Homo_sapiens__NP_001230618

<400>  6159

Met Ala Leu Ser Arg Val Cys Trp Ala Arg Ser Ala Val Trp Gly Ser 
1               5                   10                  15      


Ala Val Thr Pro Gly His Phe Val Thr Arg Arg Leu Gln Leu Gly Arg 
            20                  25                  30          


Ser Gly Leu Ala Trp Gly Ala Pro Arg Ser Ser Lys Leu His Leu Ser 
        35                  40                  45              


Pro Lys Ala Asp Val Lys Asn Leu Met Ser Tyr Val Val Thr Lys Thr 
    50                  55                  60                  


Lys Ala Ile Asn Gly Lys Tyr His Arg Phe Leu Gly Arg His Phe Pro 
65                  70                  75                  80  


Arg Phe Tyr Val Leu Tyr Thr Ile Phe Met Lys Gly Leu Gln Met Leu 
                85                  90                  95      


Trp Ala Asp Ala Lys Lys Ala Arg Arg Ile Lys Thr Asn Met Trp Lys 
            100                 105                 110         


His Asn Ile Lys Phe His Gln Leu Pro Tyr Arg Glu Met Glu His Leu 
        115                 120                 125             


Arg Gln Val Trp Ala Arg Gly Arg Tyr Pro Glu Val His Gly Glu Phe 
    130                 135                 140                 


Arg Gln Asp Val Thr Lys Cys Leu Phe Leu Gly Ile Ile Ser Ile Pro 
145                 150                 155                 160 


Pro Phe Ala Asn Tyr Leu Val Phe Leu Leu Met Tyr Leu Phe Pro Arg 
                165                 170                 175     


Gln Leu Leu Ile Arg His Phe Trp Thr Pro Lys Gln Gln Thr Asp Phe 
            180                 185                 190         


Leu Asp Ile Tyr His Ala Phe Arg Lys Gln Ser His Pro Glu Ile Ile 
        195                 200                 205             


Ser Tyr Leu Glu Lys Val Ile Pro Leu Ile Ser Asp Ala Gly Leu Arg 
    210                 215                 220                 


Trp Arg Leu Thr Asp Leu Cys Thr Lys Ile Gln Arg Gly Thr His Pro 
225                 230                 235                 240 


Ala Ile His Asp Ile Leu Ala Leu Arg Glu Cys Phe Ser Asn His Pro 
                245                 250                 255     


Leu Gly Met Asn Gln Leu Gln Ala Leu His Val Lys Ala Leu Ser Arg 
            260                 265                 270         


Ala Met Leu Leu Thr Ser Tyr Leu Pro Pro Pro Leu Leu Arg His Arg 
        275                 280                 285             


Leu Lys Thr His Thr Thr Val Ile His Gln Leu Asp Lys Ala Leu Ala 
    290                 295                 300                 


Lys Leu Gly Ile Gly Gln Leu Thr Ala Gln Glu Val Lys Ser Ala Cys 
305                 310                 315                 320 


Tyr Leu Arg Gly Leu Asn Ser Thr His Ile Gly Glu Asp Arg Cys Arg 
                325                 330                 335     


Thr Trp Leu Gly Glu Trp Leu Gln Ile Ser Cys Ser Leu Lys Glu Ala 
            340                 345                 350         


Glu Leu Ser Leu Leu Leu His Asn Val Val Leu Leu Ser Thr Asn Tyr 
        355                 360                 365             


Leu Gly Thr Arg Arg 
    370             


<210>  6160
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LEUTX__Homo_sapiens__NP_001137304

<400>  6160

Met His Pro Ser Leu Ala Thr Met Gly Lys Leu Ala Ser Lys Leu Gln 
1               5                   10                  15      


Leu Asp Leu Ser Val Val Lys Ile Trp Phe Lys Asn Gln Arg Ala Lys 
            20                  25                  30          


Trp Lys Arg Gln Gln Arg Gln Gln Met Gln Thr Arg Pro Ser Leu Gly 
        35                  40                  45              


Pro Ala Asn Gln Thr Thr Ser Val Lys Lys Glu Glu Thr Pro Ser Ala 
    50                  55                  60                  


Ile Thr Thr Ala Asn Ile Arg Pro Val Ser Pro Gly Ile Ser Asp Ala 
65                  70                  75                  80  


Asn Asp His Asp Leu Arg Glu Pro Ser Gly Ile Lys Asn Pro Gly Gly 
                85                  90                  95      


Ala Ser Ala Ser Ala Arg Val Ser Ser Trp Asp Ser Gln Ser Tyr Asp 
            100                 105                 110         


Ile Glu Gln Ile Cys Leu Gly Ala Ser Asn Pro Pro Trp Ala Ser Thr 
        115                 120                 125             


Leu Phe Glu Ile Asp Glu Phe Val Lys Ile Tyr Asp Leu Pro Gly Glu 
    130                 135                 140                 


Asp Asp Thr Ser Ser Leu Asn Gln Tyr Leu Phe Pro Val Cys Leu Glu 
145                 150                 155                 160 


Tyr Asp Gln Leu Gln Ser Ser Val 
                165             


<210>  6161
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFNG__Homo_sapiens__NP_001035257

<400>  6161

Met Leu Lys Arg Cys Gly Arg Arg Leu Leu Leu Ala Leu Ala Gly Ala 
1               5                   10                  15      


Leu Leu Ala Cys Leu Leu Val Leu Thr Ala Asp Pro Pro Pro Pro Pro 
            20                  25                  30          


Leu Pro Ala Glu Arg Gly Arg Arg Ala Leu Arg Ser Leu Ala Gly Pro 
        35                  40                  45              


Ala Gly Ala Ala Pro Ala Pro Gly Leu Gly Ala Ala Ala Ala Ala Pro 
    50                  55                  60                  


Gly Ala Leu Val Arg Asp Val His Ser Leu Ser Glu Tyr Phe Ser Leu 
65                  70                  75                  80  


Leu Thr Arg Ala Arg Arg Asp Ala Gly Pro Pro Pro Gly Ala Ala Pro 
                85                  90                  95      


Arg Pro Ala Asp Gly His Pro Arg Pro Leu Ala Glu Pro Leu Ala Pro 
            100                 105                 110         


Arg Asp Val Phe Ile Ala Val Lys Thr Thr Lys Lys Phe His Arg Ala 
        115                 120                 125             


Arg Leu Asp Leu Leu Leu Glu Thr Trp Ile Ser Arg His Lys Glu Met 
    130                 135                 140                 


Thr Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr 
145                 150                 155                 160 


Gly Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala 
                165                 170                 175     


Leu Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly 
            180                 185                 190         


Arg Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg 
        195                 200                 205             


Ala Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr 
    210                 215                 220                 


Val Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val 
225                 230                 235                 240 


Ser Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly 
                245                 250                 255     


Ala Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp 
            260                 265                 270         


Ala Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro 
        275                 280                 285             


Asp Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro 
    290                 295                 300                 


Leu Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln 
305                 310                 315                 320 


Val Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met 
                325                 330                 335     


Phe Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val 
            340                 345                 350         


Glu Ala Asp Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro 
        355                 360                 365             


Asp Thr Pro Trp Cys Pro Arg Thr Ala Ile Phe 
    370                 375                 


<210>  6162
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS12__Homo_sapiens__NP_001136007

<400>  6162

Met Ser Gln Pro Ser Gly Gly Arg Ala Pro Gly Thr Arg Ile Tyr Ser 
1               5                   10                  15      


Trp Ser Cys Pro Thr Val Met Ser Pro Gly Glu Lys Leu Asp Pro Ile 
            20                  25                  30          


Pro Asp Ser Phe Ile Leu Gln Pro Pro Val Phe His Pro Val Val Pro 
        35                  40                  45              


Tyr Val Thr Thr Ile Phe Gly Gly Leu His Ala Gly Lys Met Val Met 
    50                  55                  60                  


Leu Gln Gly Val Val Pro Leu Asp Ala His Ser Arg Phe Gln Val Asp 
65                  70                  75                  80  


Phe Gln Cys Gly Cys Ser Leu Cys Pro Arg Pro Asp Ile Ala Phe His 
                85                  90                  95      


Phe Asn Pro Arg Phe His Thr Thr Lys Pro His Val Ile Cys Asn Thr 
            100                 105                 110         


Leu His Gly Gly Arg Trp Gln Arg Glu Ala Arg Trp Pro His Leu Ala 
        115                 120                 125             


Leu Arg Arg Gly Ser Ser Phe Leu Ile Leu Phe Leu Phe Gly Asn Glu 
    130                 135                 140                 


Glu Val Lys Val Ser Val Asn Gly Gln His Phe Leu His Phe Arg Tyr 
145                 150                 155                 160 


Arg Leu Pro Leu Ser His Val Asp Thr Leu Gly Ile Phe Gly Asp Ile 
                165                 170                 175     


Leu Val Glu Ala Val Gly Phe Leu Asn Ile Asn Pro Phe Val Glu Gly 
            180                 185                 190         


Ser Arg Glu Tyr Pro Ala Gly His Pro Phe Leu Leu Met Ser Pro Arg 
        195                 200                 205             


Leu Glu Val Pro Cys Ser His Ala Leu Pro Gln Gly Leu Ser Pro Gly 
    210                 215                 220                 


Gln Val Ile Ile Val Arg Gly Leu Val Leu Gln Glu Pro Lys His Phe 
225                 230                 235                 240 


Thr Val Ser Leu Arg Asp Gln Ala Ala His Ala Pro Val Thr Leu Arg 
                245                 250                 255     


Ala Ser Phe Ala Asp Arg Thr Leu Ala Trp Ile Ser Arg Trp Gly Gln 
            260                 265                 270         


Lys Lys Leu Ile Ser Ala Pro Phe Leu Phe Tyr Pro Gln Arg Phe Phe 
        275                 280                 285             


Glu Val Leu Leu Leu Phe Gln Glu Gly Gly Leu Lys Leu Ala Leu Asn 
    290                 295                 300                 


Gly Gln Gly Leu Gly Ala Thr Ser Met Asn Gln Gln Ala Leu Glu Gln 
305                 310                 315                 320 


Leu Arg Glu Leu Arg Ile Ser Gly Ser Val Gln Leu Tyr Cys Val His 
                325                 330                 335     


Ser 
    


<210>  6163
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS13__Homo_sapiens__NP_037400

<400>  6163

Met Ser Ser Leu Pro Val Pro Tyr Lys Leu Pro Val Ser Leu Ser Val 
1               5                   10                  15      


Gly Ser Cys Val Ile Ile Lys Gly Thr Pro Ile His Ser Phe Ile Asn 
            20                  25                  30          


Asp Pro Gln Leu Gln Val Asp Phe Tyr Thr Asp Met Asp Glu Asp Ser 
        35                  40                  45              


Asp Ile Ala Phe Arg Phe Arg Val His Phe Gly Asn His Val Val Met 
    50                  55                  60                  


Asn Arg Arg Glu Phe Gly Ile Trp Met Leu Glu Glu Thr Thr Asp Tyr 
65                  70                  75                  80  


Val Pro Phe Glu Asp Gly Lys Gln Phe Glu Leu Cys Ile Tyr Val His 
                85                  90                  95      


Tyr Asn Glu Tyr Glu Ile Lys Val Asn Gly Ile Arg Ile Tyr Gly Phe 
            100                 105                 110         


Val His Arg Ile Pro Pro Ser Phe Val Lys Met Val Gln Val Ser Arg 
        115                 120                 125             


Asp Ile Ser Leu Thr Ser Val Cys Val Cys Asn 
    130                 135                 


<210>  6164
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS14__Homo_sapiens__NP_064514

<400>  6164

Met Ser Ser Leu Pro Val Pro Tyr Thr Leu Pro Val Ser Leu Pro Val 
1               5                   10                  15      


Gly Ser Cys Val Ile Ile Thr Gly Thr Pro Ile Leu Thr Phe Val Lys 
            20                  25                  30          


Asp Pro Gln Leu Glu Val Asn Phe Tyr Thr Gly Met Asp Glu Asp Ser 
        35                  40                  45              


Asp Ile Ala Phe Gln Phe Arg Leu His Phe Gly His Pro Ala Ile Met 
    50                  55                  60                  


Asn Ser Cys Val Phe Gly Ile Trp Arg Tyr Glu Glu Lys Cys Tyr Tyr 
65                  70                  75                  80  


Leu Pro Phe Glu Asp Gly Lys Pro Phe Glu Leu Cys Ile Tyr Val Arg 
                85                  90                  95      


His Lys Glu Tyr Lys Val Met Val Asn Gly Gln Arg Ile Tyr Asn Phe 
            100                 105                 110         


Ala His Arg Phe Pro Pro Ala Ser Val Lys Met Leu Gln Val Phe Arg 
        115                 120                 125             


Asp Ile Ser Leu Thr Arg Val Leu Ile Ser Asp 
    130                 135                 


<210>  6165
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS16__Homo_sapiens__NP_001177370

<400>  6165

Met Ser Phe Leu Thr Val Pro Tyr Lys Leu Pro Val Ser Leu Ser Val 
1               5                   10                  15      


Gly Ser Cys Val Ile Ile Lys Gly Thr Leu Ile Asp Ser Ser Ile Asn 
            20                  25                  30          


Glu Pro Gln Leu Gln Val Asp Phe Tyr Thr Glu Met Asn Glu Asp Ser 
        35                  40                  45              


Glu Ile Ala Phe His Leu Arg Val His Leu Gly Arg Arg Val Val Met 
    50                  55                  60                  


Asn Ser Arg Glu Phe Gly Ile Trp Met Leu Glu Glu Asn Leu His Tyr 
65                  70                  75                  80  


Val Pro Phe Glu Asp Gly Lys Pro Phe Asp Leu Arg Ile Tyr Val Cys 
                85                  90                  95      


His Asn Glu Tyr Glu Val Lys Val Asn Gly Glu Tyr Ile Tyr Ala Phe 
            100                 105                 110         


Val His Arg Ile Pro Pro Ser Tyr Val Lys Met Ile Gln Val Trp Arg 
        115                 120                 125             


Asp Val Ser Leu Asp Ser Val Leu Val Asn Asn Gly Arg Arg 
    130                 135                 140         


<210>  6166
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS1__Homo_sapiens__NP_002296

<400>  6166

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  6167
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS2__Homo_sapiens__NP_006489

<400>  6167

Met Thr Gly Glu Leu Glu Val Lys Asn Met Asp Met Lys Pro Gly Ser 
1               5                   10                  15      


Thr Leu Lys Ile Thr Gly Ser Ile Ala Asp Gly Thr Asp Gly Phe Val 
            20                  25                  30          


Ile Asn Leu Gly Gln Gly Thr Asp Lys Leu Asn Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Ser Glu Ser Thr Ile Val Cys Asn Ser Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gly Gln Glu Gln Arg Glu Asp His Leu Cys Phe Ser Pro Gly Ser 
65                  70                  75                  80  


Glu Val Lys Phe Thr Val Thr Phe Glu Ser Asp Lys Phe Lys Val Lys 
                85                  90                  95      


Leu Pro Asp Gly His Glu Leu Thr Phe Pro Asn Arg Leu Gly His Ser 
            100                 105                 110         


His Leu Ser Tyr Leu Ser Val Arg Gly Gly Phe Asn Met Ser Ser Phe 
        115                 120                 125             


Lys Leu Lys Glu 
    130         


<210>  6168
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS3BP__Homo_sapiens__NP_005558

<400>  6168

Met Thr Pro Pro Arg Leu Phe Trp Val Trp Leu Leu Val Ala Gly Thr 
1               5                   10                  15      


Gln Gly Val Asn Asp Gly Asp Met Arg Leu Ala Asp Gly Gly Ala Thr 
            20                  25                  30          


Asn Gln Gly Arg Val Glu Ile Phe Tyr Arg Gly Gln Trp Gly Thr Val 
        35                  40                  45              


Cys Asp Asn Leu Trp Asp Leu Thr Asp Ala Ser Val Val Cys Arg Ala 
    50                  55                  60                  


Leu Gly Phe Glu Asn Ala Thr Gln Ala Leu Gly Arg Ala Ala Phe Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Pro Ile Met Leu Asp Glu Val Gln Cys Thr Gly Thr 
                85                  90                  95      


Glu Ala Ser Leu Ala Asp Cys Lys Ser Leu Gly Trp Leu Lys Ser Asn 
            100                 105                 110         


Cys Arg His Glu Arg Asp Ala Gly Val Val Cys Thr Asn Glu Thr Arg 
        115                 120                 125             


Ser Thr His Thr Leu Asp Leu Ser Arg Glu Leu Ser Glu Ala Leu Gly 
    130                 135                 140                 


Gln Ile Phe Asp Ser Gln Arg Gly Cys Asp Leu Ser Ile Ser Val Asn 
145                 150                 155                 160 


Val Gln Gly Glu Asp Ala Leu Gly Phe Cys Gly His Thr Val Ile Leu 
                165                 170                 175     


Thr Ala Asn Leu Glu Ala Gln Ala Leu Trp Lys Glu Pro Gly Ser Asn 
            180                 185                 190         


Val Thr Met Ser Val Asp Ala Glu Cys Val Pro Met Val Arg Asp Leu 
        195                 200                 205             


Leu Arg Tyr Phe Tyr Ser Arg Arg Ile Asp Ile Thr Leu Ser Ser Val 
    210                 215                 220                 


Lys Cys Phe His Lys Leu Ala Ser Ala Tyr Gly Ala Arg Gln Leu Gln 
225                 230                 235                 240 


Gly Tyr Cys Ala Ser Leu Phe Ala Ile Leu Leu Pro Gln Asp Pro Ser 
                245                 250                 255     


Phe Gln Met Pro Leu Asp Leu Tyr Ala Tyr Ala Val Ala Thr Gly Asp 
            260                 265                 270         


Ala Leu Leu Glu Lys Leu Cys Leu Gln Phe Leu Ala Trp Asn Phe Glu 
        275                 280                 285             


Ala Leu Thr Gln Ala Glu Ala Trp Pro Ser Val Pro Thr Asp Leu Leu 
    290                 295                 300                 


Gln Leu Leu Leu Pro Arg Ser Asp Leu Ala Val Pro Ser Glu Leu Ala 
305                 310                 315                 320 


Leu Leu Lys Ala Val Asp Thr Trp Ser Trp Gly Glu Arg Ala Ser His 
                325                 330                 335     


Glu Glu Val Glu Gly Leu Val Glu Lys Ile Arg Phe Pro Met Met Leu 
            340                 345                 350         


Pro Glu Glu Leu Phe Glu Leu Gln Phe Asn Leu Ser Leu Tyr Trp Ser 
        355                 360                 365             


His Glu Ala Leu Phe Gln Lys Lys Thr Leu Gln Ala Leu Glu Phe His 
    370                 375                 380                 


Thr Val Pro Phe Gln Leu Leu Ala Arg Tyr Lys Gly Leu Asn Leu Thr 
385                 390                 395                 400 


Glu Asp Thr Tyr Lys Pro Arg Ile Tyr Thr Ser Pro Thr Trp Ser Ala 
                405                 410                 415     


Phe Val Thr Asp Ser Ser Trp Ser Ala Arg Lys Ser Gln Leu Val Tyr 
            420                 425                 430         


Gln Ser Arg Arg Gly Pro Leu Val Lys Tyr Ser Ser Asp Tyr Phe Gln 
        435                 440                 445             


Ala Pro Ser Asp Tyr Arg Tyr Tyr Pro Tyr Gln Ser Phe Gln Thr Pro 
    450                 455                 460                 


Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser Trp Ser Leu 
465                 470                 475                 480 


Val Tyr Leu Pro Thr Ile Gln Ser Cys Trp Asn Tyr Gly Phe Ser Cys 
                485                 490                 495     


Ser Ser Asp Glu Leu Pro Val Leu Gly Leu Thr Lys Ser Gly Gly Ser 
            500                 505                 510         


Asp Arg Thr Ile Ala Tyr Glu Asn Lys Ala Leu Met Leu Cys Glu Gly 
        515                 520                 525             


Leu Phe Val Ala Asp Val Thr Asp Phe Glu Gly Trp Lys Ala Ala Ile 
    530                 535                 540                 


Pro Ser Ala Leu Asp Thr Asn Ser Ser Lys Ser Thr Ser Ser Phe Pro 
545                 550                 555                 560 


Cys Pro Ala Gly His Phe Asn Gly Phe Arg Thr Val Ile Arg Pro Phe 
                565                 570                 575     


Tyr Leu Thr Asn Ser Ser Gly Val Asp 
            580                 585 


<210>  6169
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS3__Homo_sapiens__NP_001170859

<400>  6169

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Thr Tyr Met 
                165                 170                 175     


Cys Lys Gly Phe Met Phe Thr Val Ser Glu Asn Phe Tyr Ile His Gln 
            180                 185                 190         


Tyr Pro Ser Cys Lys Ser Ser Thr 
        195                 200 


<210>  6170
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS4__Homo_sapiens__NP_006140

<400>  6170

Met Ala Tyr Val Pro Ala Pro Gly Tyr Gln Pro Thr Tyr Asn Pro Thr 
1               5                   10                  15      


Leu Pro Tyr Tyr Gln Pro Ile Pro Gly Gly Leu Asn Val Gly Met Ser 
            20                  25                  30          


Val Tyr Ile Gln Gly Val Ala Ser Glu His Met Lys Arg Phe Phe Val 
        35                  40                  45              


Asn Phe Val Val Gly Gln Asp Pro Gly Ser Asp Val Ala Phe His Phe 
    50                  55                  60                  


Asn Pro Arg Phe Asp Gly Trp Asp Lys Val Val Phe Asn Thr Leu Gln 
65                  70                  75                  80  


Gly Gly Lys Trp Gly Ser Glu Glu Arg Lys Arg Ser Met Pro Phe Lys 
                85                  90                  95      


Lys Gly Ala Ala Phe Glu Leu Val Phe Ile Val Leu Ala Glu His Tyr 
            100                 105                 110         


Lys Val Val Val Asn Gly Asn Pro Phe Tyr Glu Tyr Gly His Arg Leu 
        115                 120                 125             


Pro Leu Gln Met Val Thr His Leu Gln Val Asp Gly Asp Leu Gln Leu 
    130                 135                 140                 


Gln Ser Ile Asn Phe Ile Gly Gly Gln Pro Leu Arg Pro Gln Gly Pro 
145                 150                 155                 160 


Pro Met Met Pro Pro Tyr Pro Gly Pro Gly His Cys His Gln Gln Leu 
                165                 170                 175     


Asn Ser Leu Pro Thr Met Glu Gly Pro Pro Thr Phe Asn Pro Pro Val 
            180                 185                 190         


Pro Tyr Phe Gly Arg Leu Gln Gly Gly Leu Thr Ala Arg Arg Thr Ile 
        195                 200                 205             


Ile Ile Lys Gly Tyr Val Pro Pro Thr Gly Lys Ser Phe Ala Ile Asn 
    210                 215                 220                 


Phe Lys Val Gly Ser Ser Gly Asp Ile Ala Leu His Ile Asn Pro Arg 
225                 230                 235                 240 


Met Gly Asn Gly Thr Val Val Arg Asn Ser Leu Leu Asn Gly Ser Trp 
                245                 250                 255     


Gly Ser Glu Glu Lys Lys Ile Thr His Asn Pro Phe Gly Pro Gly Gln 
            260                 265                 270         


Phe Phe Asp Leu Ser Ile Arg Cys Gly Leu Asp Arg Phe Lys Val Tyr 
        275                 280                 285             


Ala Asn Gly Gln His Leu Phe Asp Phe Ala His Arg Leu Ser Ala Phe 
    290                 295                 300                 


Gln Arg Val Asp Thr Leu Glu Ile Gln Gly Asp Val Thr Leu Ser Tyr 
305                 310                 315                 320 


Val Gln Ile 
            


<210>  6171
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS7B__Homo_sapiens__NP_001035972

<400>  6171

Met Ser Asn Val Pro His Lys Ser Ser Leu Pro Glu Gly Ile Arg Pro 
1               5                   10                  15      


Gly Thr Val Leu Arg Ile Arg Gly Leu Val Pro Pro Asn Ala Ser Arg 
            20                  25                  30          


Phe His Val Asn Leu Leu Cys Gly Glu Glu Gln Gly Ser Asp Ala Ala 
        35                  40                  45              


Leu His Phe Asn Pro Arg Leu Asp Thr Ser Glu Val Val Phe Asn Ser 
    50                  55                  60                  


Lys Glu Gln Gly Ser Trp Gly Arg Glu Glu Arg Gly Pro Gly Val Pro 
65                  70                  75                  80  


Phe Gln Arg Gly Gln Pro Phe Glu Val Leu Ile Ile Ala Ser Asp Asp 
                85                  90                  95      


Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His Phe Arg His 
            100                 105                 110         


Arg Leu Pro Leu Ala Arg Val Arg Leu Val Glu Val Gly Gly Asp Val 
        115                 120                 125             


Gln Leu Asp Ser Val Arg Ile Phe 
    130                 135     


<210>  6172
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS8__Homo_sapiens__NP_006490

<400>  6172

Met Met Leu Ser Leu Asn Asn Leu Gln Asn Ile Ile Tyr Asn Pro Val 
1               5                   10                  15      


Ile Pro Phe Val Gly Thr Ile Pro Asp Gln Leu Asp Pro Gly Thr Leu 
            20                  25                  30          


Ile Val Ile Arg Gly His Val Pro Ser Asp Ala Asp Arg Phe Gln Val 
        35                  40                  45              


Asp Leu Gln Asn Gly Ser Ser Met Lys Pro Arg Ala Asp Val Ala Phe 
    50                  55                  60                  


His Phe Asn Pro Arg Phe Lys Arg Ala Gly Cys Ile Val Cys Asn Thr 
65                  70                  75                  80  


Leu Ile Asn Glu Lys Trp Gly Arg Glu Glu Ile Thr Tyr Asp Thr Pro 
                85                  90                  95      


Phe Lys Arg Glu Lys Ser Phe Glu Ile Val Ile Met Val Leu Lys Asp 
            100                 105                 110         


Lys Phe Gln Val Ala Val Asn Gly Lys His Thr Leu Leu Tyr Gly His 
        115                 120                 125             


Arg Ile Gly Pro Glu Lys Ile Asp Thr Leu Gly Ile Tyr Gly Lys Val 
    130                 135                 140                 


Asn Ile His Ser Ile Gly Phe Ser Phe Ser Ser Asp Leu Gln Ser Thr 
145                 150                 155                 160 


Gln Ala Ser Ser Leu Glu Leu Thr Glu Ile Ser Arg Glu Asn Val Pro 
                165                 170                 175     


Lys Ser Gly Thr Pro Gln Leu Pro Ser Asn Arg Gly Gly Asp Ile Ser 
            180                 185                 190         


Lys Ile Ala Pro Arg Thr Val Tyr Thr Lys Ser Lys Asp Ser Thr Val 
        195                 200                 205             


Asn His Thr Leu Thr Cys Thr Lys Ile Pro Pro Met Asn Tyr Val Ser 
    210                 215                 220                 


Lys Arg Leu Pro Phe Ala Ala Arg Leu Asn Thr Pro Met Gly Pro Gly 
225                 230                 235                 240 


Arg Thr Val Val Val Lys Gly Glu Val Asn Ala Asn Ala Lys Ser Phe 
                245                 250                 255     


Asn Val Asp Leu Leu Ala Gly Lys Ser Lys Asp Ile Ala Leu His Leu 
            260                 265                 270         


Asn Pro Arg Leu Asn Ile Lys Ala Phe Val Arg Asn Ser Phe Leu Gln 
        275                 280                 285             


Glu Ser Trp Gly Glu Glu Glu Arg Asn Ile Thr Ser Phe Pro Phe Ser 
    290                 295                 300                 


Pro Gly Met Tyr Phe Glu Met Ile Ile Tyr Cys Asp Val Arg Glu Phe 
305                 310                 315                 320 


Lys Val Ala Val Asn Gly Val His Ser Leu Glu Tyr Lys His Arg Phe 
                325                 330                 335     


Lys Glu Leu Ser Ser Ile Asp Thr Leu Glu Ile Asn Gly Asp Ile His 
            340                 345                 350         


Leu Leu Glu Val Arg Ser Trp 
        355                 


<210>  6173
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALS9__Homo_sapiens__NP_002299

<400>  6173

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
145                 150                 155                 160 


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
                165                 170                 175     


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
            180                 185                 190         


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
        195                 200                 205             


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
    210                 215                 220                 


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
225                 230                 235                 240 


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
                245                 250                 255     


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
            260                 265                 270         


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
        275                 280                 285             


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
    290                 295                 300                 


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
305                 310                 315                 320 


Val Gln Thr 
            


<210>  6174
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGALSL__Homo_sapiens__NP_054900

<400>  6174

Met Ala Gly Ser Val Ala Asp Ser Asp Ala Val Val Lys Leu Asp Asp 
1               5                   10                  15      


Gly His Leu Asn Asn Ser Leu Ser Ser Pro Val Gln Ala Asp Val Tyr 
            20                  25                  30          


Phe Pro Arg Leu Ile Val Pro Phe Cys Gly His Ile Lys Gly Gly Met 
        35                  40                  45              


Arg Pro Gly Lys Lys Val Leu Val Met Gly Ile Val Asp Leu Asn Pro 
    50                  55                  60                  


Glu Ser Phe Ala Ile Ser Leu Thr Cys Gly Asp Ser Glu Asp Pro Pro 
65                  70                  75                  80  


Ala Asp Val Ala Ile Glu Leu Lys Ala Val Phe Thr Asp Arg Gln Leu 
                85                  90                  95      


Leu Arg Asn Ser Cys Ile Ser Gly Glu Arg Gly Glu Glu Gln Ser Ala 
            100                 105                 110         


Ile Pro Tyr Phe Pro Phe Ile Pro Asp Gln Pro Phe Arg Val Glu Ile 
        115                 120                 125             


Leu Cys Glu His Pro Arg Phe Arg Val Phe Val Asp Gly His Gln Leu 
    130                 135                 140                 


Phe Asp Phe Tyr His Arg Ile Gln Thr Leu Ser Ala Ile Asp Thr Ile 
145                 150                 155                 160 


Lys Ile Asn Gly Asp Leu Gln Ile Thr Lys Leu Gly 
                165                 170         


<210>  6175
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGI1__Homo_sapiens__NP_005088

<400>  6175

Met Glu Ser Glu Arg Ser Lys Arg Met Gly Asn Ala Cys Ile Pro Leu 
1               5                   10                  15      


Lys Arg Ile Ala Tyr Phe Leu Cys Leu Leu Ser Ala Leu Leu Leu Thr 
            20                  25                  30          


Glu Gly Lys Lys Pro Ala Lys Pro Lys Cys Pro Ala Val Cys Thr Cys 
        35                  40                  45              


Thr Lys Asp Asn Ala Leu Cys Glu Asn Ala Arg Ser Ile Pro Arg Thr 
    50                  55                  60                  


Val Pro Pro Asp Val Ile Ser Leu Ser Phe Val Arg Ser Gly Phe Thr 
65                  70                  75                  80  


Glu Ile Ser Glu Gly Ser Phe Leu Phe Thr Pro Ser Leu Gln Leu Leu 
                85                  90                  95      


Leu Phe Thr Ser Asn Ser Phe Asp Val Ile Ser Asp Asp Ala Phe Ile 
            100                 105                 110         


Gly Leu Pro His Leu Glu Tyr Leu Phe Ile Glu Asn Asn Asn Ile Lys 
        115                 120                 125             


Ser Ile Ser Arg His Thr Phe Arg Gly Leu Lys Ser Leu Ile His Leu 
    130                 135                 140                 


Ser Leu Ala Asn Asn Asn Leu Gln Thr Leu Pro Lys Asp Ile Phe Lys 
145                 150                 155                 160 


Gly Leu Asp Ser Leu Thr Asn Val Asp Leu Arg Gly Asn Ser Phe Asn 
                165                 170                 175     


Cys Asp Cys Lys Leu Lys Trp Leu Val Glu Trp Leu Gly His Thr Asn 
            180                 185                 190         


Ala Thr Val Glu Asp Ile Tyr Cys Glu Gly Pro Pro Glu Tyr Lys Lys 
        195                 200                 205             


Arg Lys Ile Asn Ser Leu Ser Ser Lys Asp Phe Asp Cys Ile Ile Thr 
    210                 215                 220                 


Glu Phe Ala Lys Ser Gln Asp Leu Pro Tyr Gln Ser Leu Ser Ile Asp 
225                 230                 235                 240 


Thr Phe Ser Tyr Leu Asn Asp Glu Tyr Val Val Ile Ala Gln Pro Phe 
                245                 250                 255     


Thr Gly Lys Cys Ile Phe Leu Glu Trp Asp His Val Glu Lys Thr Phe 
            260                 265                 270         


Arg Asn Tyr Asp Asn Ile Thr Gly Thr Ser Thr Val Val Cys Lys Pro 
        275                 280                 285             


Ile Val Ile Glu Thr Gln Leu Tyr Val Ile Val Ala Gln Leu Phe Gly 
    290                 295                 300                 


Gly Ser His Ile Tyr Lys Arg Asp Ser Phe Ala Asn Lys Phe Ile Lys 
305                 310                 315                 320 


Ile Gln Asp Ile Glu Ile Leu Lys Ile Arg Lys Pro Asn Asp Ile Glu 
                325                 330                 335     


Thr Phe Lys Ile Glu Asn Asn Trp Tyr Phe Val Val Ala Asp Ser Ser 
            340                 345                 350         


Lys Ala Gly Phe Thr Thr Ile Tyr Lys Trp Asn Gly Asn Gly Phe Tyr 
        355                 360                 365             


Ser His Gln Ser Leu His Ala Trp Tyr Arg Asp Thr Asp Val Glu Tyr 
    370                 375                 380                 


Leu Glu Ile Val Arg Thr Pro Gln Thr Leu Arg Thr Pro His Leu Ile 
385                 390                 395                 400 


Leu Ser Ser Ser Ser Gln Arg Pro Val Ile Tyr Gln Trp Asn Lys Ala 
                405                 410                 415     


Thr Gln Leu Phe Thr Asn Gln Thr Asp Ile Pro Asn Met Glu Asp Val 
            420                 425                 430         


Tyr Ala Val Lys His Phe Ser Val Lys Gly Asp Val Tyr Ile Cys Leu 
        435                 440                 445             


Thr Arg Phe Ile Gly Asp Ser Lys Val Met Lys Trp Gly Gly Ser Ser 
    450                 455                 460                 


Phe Gln Asp Ile Gln Arg Met Pro Ser Arg Gly Ser Met Val Phe Gln 
465                 470                 475                 480 


Pro Leu Gln Ile Asn Asn Tyr Gln Tyr Ala Ile Leu Gly Ser Asp Tyr 
                485                 490                 495     


Ser Phe Thr Gln Val Tyr Asn Trp Asp Ala Glu Lys Ala Lys Phe Val 
            500                 505                 510         


Lys Phe Gln Glu Leu Asn Val Gln Ala Pro Arg Ser Phe Thr His Val 
        515                 520                 525             


Ser Ile Asn Lys Arg Asn Phe Leu Phe Ala Ser Ser Phe Lys Gly Asn 
    530                 535                 540                 


Thr Gln Ile Tyr Lys His Val Ile Val Asp Leu Ser Ala 
545                 550                 555         


<210>  6176
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGI2__Homo_sapiens__NP_060646

<400>  6176

Met Ala Leu Arg Arg Gly Gly Cys Gly Ala Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gly Ala Ala Cys Leu Ile Pro Arg Ser Ala Gln Val Arg Arg 
            20                  25                  30          


Leu Ala Arg Cys Pro Ala Thr Cys Ser Cys Thr Lys Glu Ser Ile Ile 
        35                  40                  45              


Cys Val Gly Ser Ser Trp Val Pro Arg Ile Val Pro Gly Asp Ile Ser 
    50                  55                  60                  


Ser Leu Ser Leu Val Asn Gly Thr Phe Ser Glu Ile Lys Asp Arg Met 
65                  70                  75                  80  


Phe Ser His Leu Pro Ser Leu Gln Leu Leu Leu Leu Asn Ser Asn Ser 
                85                  90                  95      


Phe Thr Ile Ile Arg Asp Asp Ala Phe Ala Gly Leu Phe His Leu Glu 
            100                 105                 110         


Tyr Leu Phe Ile Glu Gly Asn Lys Ile Glu Thr Ile Ser Arg Asn Ala 
        115                 120                 125             


Phe Arg Gly Leu Arg Asp Leu Thr His Leu Ser Leu Ala Asn Asn His 
    130                 135                 140                 


Ile Lys Ala Leu Pro Arg Asp Val Phe Ser Asp Leu Asp Ser Leu Ile 
145                 150                 155                 160 


Glu Leu Asp Leu Arg Gly Asn Lys Phe Glu Cys Asp Cys Lys Ala Lys 
                165                 170                 175     


Trp Leu Tyr Leu Trp Leu Lys Met Thr Asn Ser Thr Val Ser Asp Val 
            180                 185                 190         


Leu Cys Ile Gly Pro Pro Glu Tyr Gln Glu Lys Lys Leu Asn Asp Val 
        195                 200                 205             


Thr Ser Phe Asp Tyr Glu Cys Thr Thr Thr Asp Phe Val Val His Gln 
    210                 215                 220                 


Thr Leu Pro Tyr Gln Ser Val Ser Val Asp Thr Phe Asn Ser Lys Asn 
225                 230                 235                 240 


Asp Val Tyr Val Ala Ile Ala Gln Pro Ser Met Glu Asn Cys Met Val 
                245                 250                 255     


Leu Glu Trp Asp His Ile Glu Met Asn Phe Arg Ser Tyr Asp Asn Ile 
            260                 265                 270         


Thr Gly Gln Ser Ile Val Gly Cys Lys Ala Ile Leu Ile Asp Asp Gln 
        275                 280                 285             


Val Phe Val Val Val Ala Gln Leu Phe Gly Gly Ser His Ile Tyr Lys 
    290                 295                 300                 


Tyr Asp Glu Ser Trp Thr Lys Phe Val Lys Phe Gln Asp Ile Glu Val 
305                 310                 315                 320 


Ser Arg Ile Ser Lys Pro Asn Asp Ile Glu Leu Phe Gln Ile Asp Asp 
                325                 330                 335     


Glu Thr Phe Phe Val Ile Ala Asp Ser Ser Lys Ala Gly Leu Ser Thr 
            340                 345                 350         


Val Tyr Lys Trp Asn Ser Lys Gly Phe Tyr Ser Tyr Gln Ser Leu His 
        355                 360                 365             


Glu Trp Phe Arg Asp Thr Asp Ala Glu Phe Val Asp Ile Asp Gly Lys 
    370                 375                 380                 


Ser His Leu Ile Leu Ser Ser Arg Ser Gln Val Pro Ile Ile Leu Gln 
385                 390                 395                 400 


Trp Asn Lys Ser Ser Lys Lys Phe Val Pro His Gly Asp Ile Pro Asn 
                405                 410                 415     


Met Glu Asp Val Leu Ala Val Lys Ser Phe Arg Met Gln Asn Thr Leu 
            420                 425                 430         


Tyr Leu Ser Leu Thr Arg Phe Ile Gly Asp Ser Arg Val Met Arg Trp 
        435                 440                 445             


Asn Ser Lys Gln Phe Val Glu Ile Gln Ala Leu Pro Ser Arg Gly Ala 
    450                 455                 460                 


Met Thr Leu Gln Pro Phe Ser Phe Lys Asp Asn His Tyr Leu Ala Leu 
465                 470                 475                 480 


Gly Ser Asp Tyr Thr Phe Ser Gln Ile Tyr Gln Trp Asp Lys Glu Lys 
                485                 490                 495     


Gln Leu Phe Lys Lys Phe Lys Glu Ile Tyr Val Gln Ala Pro Arg Ser 
            500                 505                 510         


Phe Thr Ala Val Ser Thr Asp Arg Arg Asp Phe Phe Phe Ala Ser Ser 
        515                 520                 525             


Phe Lys Gly Lys Thr Lys Ile Phe Glu His Ile Ile Val Asp Leu Ser 
    530                 535                 540                 


Leu 
545 


<210>  6177
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGI4__Homo_sapiens__NP_644813

<400>  6177

Met Gly Gly Ala Gly Ile Leu Leu Leu Leu Leu Ala Gly Ala Gly Val 
1               5                   10                  15      


Val Val Ala Trp Arg Pro Pro Lys Gly Lys Cys Pro Leu Arg Cys Ser 
            20                  25                  30          


Cys Ser Lys Asp Ser Ala Leu Cys Glu Gly Ser Pro Asp Leu Pro Val 
        35                  40                  45              


Ser Phe Ser Pro Thr Leu Leu Ser Leu Ser Leu Val Arg Thr Gly Val 
    50                  55                  60                  


Thr Gln Leu Lys Ala Gly Ser Phe Leu Arg Ile Pro Ser Leu His Leu 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Ser Phe Ser Val Ile Glu Asp Asp Ala Phe 
                85                  90                  95      


Ala Gly Leu Ser His Leu Gln Tyr Leu Phe Ile Glu Asp Asn Glu Ile 
            100                 105                 110         


Gly Ser Ile Ser Lys Asn Ala Leu Arg Gly Leu Arg Ser Leu Thr His 
        115                 120                 125             


Leu Ser Leu Ala Asn Asn His Leu Glu Thr Leu Pro Arg Phe Leu Phe 
    130                 135                 140                 


Arg Gly Leu Asp Thr Leu Thr His Val Asp Leu Arg Gly Asn Pro Phe 
145                 150                 155                 160 


Gln Cys Asp Cys Arg Val Leu Trp Leu Leu Gln Trp Met Pro Thr Val 
                165                 170                 175     


Asn Ala Ser Val Gly Thr Gly Ala Cys Ala Gly Pro Ala Ser Leu Ser 
            180                 185                 190         


His Met Gln Leu His His Leu Asp Pro Lys Thr Phe Lys Cys Arg Ala 
        195                 200                 205             


Ile Glu Leu Ser Trp Phe Gln Thr Val Gly Glu Ser Ala Leu Ser Val 
    210                 215                 220                 


Glu Pro Phe Ser Tyr Gln Gly Glu Pro His Ile Val Leu Ala Gln Pro 
225                 230                 235                 240 


Phe Ala Gly Arg Cys Leu Ile Leu Ser Trp Asp Tyr Ser Leu Gln Arg 
                245                 250                 255     


Phe Arg Pro Glu Glu Glu Leu Pro Ala Ala Ser Val Val Ser Cys Lys 
            260                 265                 270         


Pro Leu Val Leu Gly Pro Ser Leu Phe Val Leu Ala Ala Arg Leu Trp 
        275                 280                 285             


Gly Gly Ser Gln Leu Trp Ala Arg Pro Ser Pro Gly Leu Arg Leu Ala 
    290                 295                 300                 


Pro Thr Gln Thr Leu Ala Pro Arg Arg Leu Leu Arg Pro Asn Asp Ala 
305                 310                 315                 320 


Glu Leu Leu Trp Leu Glu Gly Gln Pro Cys Phe Val Val Ala Asp Ala 
                325                 330                 335     


Ser Lys Ala Gly Ser Thr Thr Leu Leu Cys Arg Asp Gly Pro Gly Phe 
            340                 345                 350         


Tyr Pro His Gln Ser Leu His Ala Trp His Arg Asp Thr Asp Ala Glu 
        355                 360                 365             


Ala Leu Glu Leu Asp Gly Arg Pro His Leu Leu Leu Ala Ser Ala Ser 
    370                 375                 380                 


Gln Arg Pro Val Leu Phe His Trp Thr Gly Gly Arg Phe Glu Arg Arg 
385                 390                 395                 400 


Thr Asp Ile Pro Glu Ala Glu Asp Val Tyr Ala Thr Arg His Phe Gln 
                405                 410                 415     


Ala Gly Gly Asp Val Phe Leu Cys Leu Thr Arg Tyr Ile Gly Asp Ser 
            420                 425                 430         


Met Val Met Arg Trp Asp Gly Ser Met Phe Arg Leu Leu Gln Gln Leu 
        435                 440                 445             


Pro Ser Arg Gly Ala His Val Phe Gln Pro Leu Leu Ile Ala Arg Asp 
    450                 455                 460                 


Gln Leu Ala Ile Leu Gly Ser Asp Phe Ala Phe Ser Gln Val Leu Arg 
465                 470                 475                 480 


Leu Glu Pro Asp Lys Gly Leu Leu Glu Pro Leu Gln Glu Leu Gly Pro 
                485                 490                 495     


Pro Ala Leu Val Ala Pro Arg Ala Phe Ala His Ile Thr Met Ala Gly 
            500                 505                 510         


Arg Arg Phe Leu Phe Ala Ala Cys Phe Lys Gly Pro Thr Gln Ile Tyr 
        515                 520                 525             


Gln His His Glu Ile Asp Leu Ser Ala 
    530                 535         


<210>  6178
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGMN__Homo_sapiens__NP_005597

<400>  6178

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
            340                 345                 350         


Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
        355                 360                 365             


Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
    370                 375                 380                 


His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
385                 390                 395                 400 


Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                405                 410                 415     


Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
            420                 425                 430         


Tyr 
    


<210>  6179
<211>  951
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGR4__Homo_sapiens__NP_060960

<400>  6179

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
    50                  55                  60                  


Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Asn Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn Asp Leu Ser Phe Ile 
                85                  90                  95      


His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu Lys Val Leu Thr Leu 
            100                 105                 110         


Gln Asn Asn Gln Leu Lys Thr Val Pro Ser Glu Ala Ile Arg Gly Leu 
        115                 120                 125             


Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
    130                 135                 140                 


Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
145                 150                 155                 160 


Asp Asp Asn Ser Leu Thr Glu Val Pro Val His Pro Leu Ser Asn Leu 
                165                 170                 175     


Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Lys Ile Ser Ser Ile 
            180                 185                 190         


Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu His Leu 
        195                 200                 205             


His Asn Asn Lys Ile Arg Ser Leu Ser Gln His Cys Phe Asp Gly Leu 
    210                 215                 220                 


Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn Asn Leu Gly Glu Phe 
225                 230                 235                 240 


Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys Glu Leu Gly Phe His 
                245                 250                 255     


Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala Phe Asp Gly Asn Pro 
            260                 265                 270         


Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro Leu Ser Phe Val Gly 
        275                 280                 285             


Asn Ser Ala Phe His Asn Leu Ser Asp Leu His Ser Leu Val Ile Arg 
    290                 295                 300                 


Gly Ala Ser Met Val Gln Gln Phe Pro Asn Leu Thr Gly Thr Val His 
305                 310                 315                 320 


Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asn 
                325                 330                 335     


Asn Leu Cys Gln Glu Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr 
            340                 345                 350         


Asn Asn Ile Arg Asp Leu Pro Ser Phe Asn Gly Cys His Ala Leu Glu 
        355                 360                 365             


Glu Ile Ser Leu Gln Arg Asn Gln Ile Tyr Gln Ile Lys Glu Gly Thr 
    370                 375                 380                 


Phe Gln Gly Leu Ile Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu 
385                 390                 395                 400 


Ile His Glu Ile His Ser Arg Ala Phe Ala Thr Leu Gly Pro Ile Thr 
                405                 410                 415     


Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly 
            420                 425                 430         


Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys 
        435                 440                 445             


Glu Ala Leu Ala Ala Lys Asp Phe Val Asn Leu Arg Ser Leu Ser Val 
    450                 455                 460                 


Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala 
465                 470                 475                 480 


Asn Leu Asn Thr Glu Asp Asn Ser Leu Gln Asp His Ser Val Ala Gln 
                485                 490                 495     


Glu Lys Gly Thr Ala Asp Ala Ala Asn Val Thr Ser Thr Leu Glu Asn 
            500                 505                 510         


Glu Glu His Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala 
        515                 520                 525             


Phe Lys Pro Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Leu Thr 
    530                 535                 540                 


Val Trp Phe Ile Phe Leu Val Ala Leu Phe Phe Asn Leu Leu Val Ile 
545                 550                 555                 560 


Leu Thr Thr Phe Ala Ser Cys Thr Ser Leu Pro Ser Ser Lys Leu Phe 
                565                 570                 575     


Ile Gly Leu Ile Ser Val Ser Asn Leu Phe Met Gly Ile Tyr Thr Gly 
            580                 585                 590         


Ile Leu Thr Phe Leu Asp Ala Val Ser Trp Gly Arg Phe Ala Glu Phe 
        595                 600                 605             


Gly Ile Trp Trp Glu Thr Gly Ser Gly Cys Lys Val Ala Gly Phe Leu 
    610                 615                 620                 


Ala Val Phe Ser Ser Glu Ser Ala Ile Phe Leu Leu Met Leu Ala Thr 
625                 630                 635                 640 


Val Glu Arg Ser Leu Ser Ala Lys Asp Ile Met Lys Asn Gly Lys Ser 
                645                 650                 655     


Asn His Leu Lys Gln Phe Arg Val Ala Ala Leu Leu Ala Phe Leu Gly 
            660                 665                 670         


Ala Thr Val Ala Gly Cys Phe Pro Leu Phe His Arg Gly Glu Tyr Ser 
        675                 680                 685             


Ala Ser Pro Leu Cys Leu Pro Phe Pro Thr Gly Glu Thr Pro Ser Leu 
    690                 695                 700                 


Gly Phe Thr Val Thr Leu Val Leu Leu Asn Ser Leu Ala Phe Leu Leu 
705                 710                 715                 720 


Met Ala Val Ile Tyr Thr Lys Leu Tyr Cys Asn Leu Glu Lys Glu Asp 
                725                 730                 735     


Leu Ser Glu Asn Ser Gln Ser Ser Met Ile Lys His Val Ala Trp Leu 
            740                 745                 750         


Ile Phe Thr Asn Cys Ile Phe Phe Cys Pro Val Ala Phe Phe Ser Phe 
        755                 760                 765             


Ala Pro Leu Ile Thr Ala Ile Ser Ile Ser Pro Glu Ile Met Lys Ser 
    770                 775                 780                 


Val Thr Leu Ile Phe Phe Pro Leu Pro Ala Cys Leu Asn Pro Val Leu 
785                 790                 795                 800 


Tyr Val Phe Phe Asn Pro Lys Phe Lys Glu Asp Trp Lys Leu Leu Lys 
                805                 810                 815     


Arg Arg Val Thr Lys Lys Ser Gly Ser Val Ser Val Ser Ile Ser Ser 
            820                 825                 830         


Gln Gly Gly Cys Leu Glu Gln Asp Phe Tyr Tyr Asp Cys Gly Met Tyr 
        835                 840                 845             


Ser His Leu Gln Gly Asn Leu Thr Val Cys Asp Cys Cys Glu Ser Phe 
    850                 855                 860                 


Leu Leu Thr Lys Pro Val Ser Cys Lys His Leu Ile Lys Ser His Ser 
865                 870                 875                 880 


Cys Pro Ala Leu Ala Val Ala Ser Cys Gln Arg Pro Glu Gly Tyr Trp 
                885                 890                 895     


Ser Asp Cys Gly Thr Gln Ser Ala His Ser Asp Tyr Ala Asp Glu Glu 
            900                 905                 910         


Asp Ser Phe Val Ser Asp Ser Ser Asp Gln Val Gln Ala Cys Gly Arg 
        915                 920                 925             


Ala Cys Phe Tyr Gln Ser Arg Gly Phe Pro Leu Val Arg Tyr Ala Tyr 
    930                 935                 940                 


Asn Leu Pro Arg Val Lys Asp 
945                 950     


<210>  6180
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGR5__Homo_sapiens__NP_001264155

<400>  6180

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu His Phe Tyr Asp Asn Pro Ile Gln Phe Val 
            260                 265                 270         


Gly Arg Ser Ala Phe Gln His Leu Pro Glu Leu Arg Thr Leu Thr Leu 
        275                 280                 285             


Asn Gly Ala Ser Gln Ile Thr Glu Phe Pro Asp Leu Thr Gly Thr Ala 
    290                 295                 300                 


Asn Leu Glu Ser Leu Thr Leu Thr Gly Ala Gln Ile Ser Ser Leu Pro 
305                 310                 315                 320 


Gln Thr Val Cys Asn Gln Leu Pro Asn Leu Gln Val Leu Asp Leu Ser 
                325                 330                 335     


Tyr Asn Leu Leu Glu Asp Leu Pro Ser Phe Ser Val Cys Gln Lys Leu 
            340                 345                 350         


Gln Lys Ile Asp Leu Arg His Asn Glu Ile Tyr Glu Ile Lys Val Asp 
        355                 360                 365             


Thr Phe Gln Gln Leu Leu Ser Leu Arg Ser Leu Asn Leu Ala Trp Asn 
    370                 375                 380                 


Lys Ile Ala Ile Ile His Pro Asn Ala Phe Ser Thr Leu Pro Ser Leu 
385                 390                 395                 400 


Ile Lys Leu Asp Leu Ser Ser Asn Leu Leu Ser Ser Phe Pro Ile Thr 
                405                 410                 415     


Gly Leu His Gly Leu Thr His Leu Lys Leu Thr Gly Asn His Ala Leu 
            420                 425                 430         


Gln Ser Leu Ile Ser Ser Glu Asn Phe Pro Glu Leu Lys Val Ile Glu 
        435                 440                 445             


Met Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Gly Val Cys Glu Asn Ala 
    450                 455                 460                 


Tyr Lys Ile Ser Asn Gln Trp Asn Lys Gly Asp Asn Ser Ser Met Asp 
465                 470                 475                 480 


Asp Leu His Lys Lys Asp Ala Gly Met Phe Gln Ala Gln Asp Glu Arg 
                485                 490                 495     


Asp Leu Glu Asp Phe Leu Leu Asp Phe Glu Glu Asp Leu Lys Ala Leu 
            500                 505                 510         


His Ser Val Gln Cys Ser Pro Ser Pro Gly Pro Phe Lys Pro Cys Glu 
        515                 520                 525             


His Leu Leu Asp Gly Trp Leu Ile Arg Ile Gly Val Trp Thr Ile Ala 
    530                 535                 540                 


Val Leu Ala Leu Thr Cys Asn Ala Leu Val Thr Ser Thr Val Phe Arg 
545                 550                 555                 560 


Ser Pro Leu Tyr Ile Ser Pro Ile Lys Leu Leu Ile Gly Val Ile Ala 
                565                 570                 575     


Ala Val Asn Met Leu Thr Gly Val Ser Ser Ala Val Leu Ala Gly Val 
            580                 585                 590         


Asp Ala Phe Thr Phe Gly Ser Phe Ala Arg His Gly Ala Trp Trp Glu 
        595                 600                 605             


Asn Gly Val Gly Cys His Val Ile Gly Phe Leu Ser Ile Phe Ala Ser 
    610                 615                 620                 


Glu Ser Ser Val Phe Leu Leu Thr Leu Ala Ala Leu Glu Arg Gly Phe 
625                 630                 635                 640 


Ser Val Lys Tyr Ser Ala Lys Phe Glu Thr Lys Ala Pro Phe Ser Ser 
                645                 650                 655     


Leu Lys Val Ile Ile Leu Leu Cys Ala Leu Leu Ala Leu Thr Met Ala 
            660                 665                 670         


Ala Val Pro Leu Leu Gly Gly Ser Lys Tyr Gly Ala Ser Pro Leu Cys 
        675                 680                 685             


Leu Pro Leu Pro Phe Gly Glu Pro Ser Thr Met Gly Tyr Met Val Ala 
    690                 695                 700                 


Leu Ile Leu Leu Asn Ser Leu Cys Phe Leu Met Met Thr Ile Ala Tyr 
705                 710                 715                 720 


Thr Lys Leu Tyr Cys Asn Leu Asp Lys Gly Asp Leu Glu Asn Ile Trp 
                725                 730                 735     


Asp Cys Ser Met Val Lys His Ile Ala Leu Leu Leu Phe Thr Asn Cys 
            740                 745                 750         


Ile Leu Asn Cys Pro Val Ala Phe Leu Ser Phe Ser Ser Leu Ile Asn 
        755                 760                 765             


Leu Thr Phe Ile Ser Pro Glu Val Ile Lys Phe Ile Leu Leu Val Val 
    770                 775                 780                 


Val Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu Tyr Ile Leu Phe Asn 
785                 790                 795                 800 


Pro His Phe Lys Glu Asp Leu Val Ser Leu Arg Lys Gln Thr Tyr Val 
                805                 810                 815     


Trp Thr Arg Ser Lys His Pro Ser Leu Met Ser Ile Asn Ser Asp Asp 
            820                 825                 830         


Val Glu Lys Gln Ser Cys Asp Ser Thr Gln Ala Leu Val Thr Phe Thr 
        835                 840                 845             


Ser Ser Ser Ile Thr Tyr Asp Leu Pro Pro Ser Ser Val Pro Ser Pro 
    850                 855                 860                 


Ala Tyr Pro Val Thr Glu Ser Cys His Leu Ser Ser Val Ala Phe Val 
865                 870                 875                 880 


Pro Cys Leu 
            


<210>  6181
<211>  967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGR6__Homo_sapiens__NP_001017403

<400>  6181

Met Pro Ser Pro Pro Gly Leu Arg Ala Leu Trp Leu Cys Ala Ala Leu 
1               5                   10                  15      


Cys Ala Ser Arg Arg Ala Gly Gly Ala Pro Gln Pro Gly Pro Gly Pro 
            20                  25                  30          


Thr Ala Cys Pro Ala Pro Cys His Cys Gln Glu Asp Gly Ile Met Leu 
        35                  40                  45              


Ser Ala Asp Cys Ser Glu Leu Gly Leu Ser Ala Val Pro Gly Asp Leu 
    50                  55                  60                  


Asp Pro Leu Thr Ala Tyr Leu Asp Leu Ser Met Asn Asn Leu Thr Glu 
65                  70                  75                  80  


Leu Gln Pro Gly Leu Phe His His Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ser Gly Asn His Leu Ser His Ile Pro Gly Gln Ala Phe Ser Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Ile Leu Met Leu Gln Asn Asn Gln Leu Gly Gly 
        115                 120                 125             


Ile Pro Ala Glu Ala Leu Trp Glu Leu Pro Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn Leu Ile Ser Leu Val Pro Glu Arg Ser Phe Glu Gly 
145                 150                 155                 160 


Leu Ser Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Arg Ala Leu Asn Asn Leu Pro Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Arg Ile Ser His Ile Pro Asp Tyr Ala Phe Gln Asn 
        195                 200                 205             


Leu Thr Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile Gln His 
    210                 215                 220                 


Leu Gly Thr His Ser Phe Glu Gly Leu His Asn Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Lys Leu Gln Glu Phe Pro Val Ala Ile Arg Thr Leu 
                245                 250                 255     


Gly Arg Leu Gln Glu Leu Gly Phe His Asn Asn Asn Ile Lys Ala Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Met Gly Asn Pro Leu Leu Gln Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln Tyr Leu 
    290                 295                 300                 


Pro Lys Leu His Thr Leu Ser Leu Asn Gly Ala Met Asp Ile Gln Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Lys Gly Thr Thr Ser Leu Glu Ile Leu Thr Leu Thr 
                325                 330                 335     


Arg Ala Gly Ile Arg Leu Leu Pro Ser Gly Met Cys Gln Gln Leu Pro 
            340                 345                 350         


Arg Leu Arg Val Leu Glu Leu Ser His Asn Gln Ile Glu Glu Leu Pro 
        355                 360                 365             


Ser Leu His Arg Cys Gln Lys Leu Glu Glu Ile Gly Leu Gln His Asn 
    370                 375                 380                 


Arg Ile Trp Glu Ile Gly Ala Asp Thr Phe Ser Gln Leu Ser Ser Leu 
385                 390                 395                 400 


Gln Ala Leu Asp Leu Ser Trp Asn Ala Ile Arg Ser Ile His Pro Glu 
                405                 410                 415     


Ala Phe Ser Thr Leu His Ser Leu Val Lys Leu Asp Leu Thr Asp Asn 
            420                 425                 430         


Gln Leu Thr Thr Leu Pro Leu Ala Gly Leu Gly Gly Leu Met His Leu 
        435                 440                 445             


Lys Leu Lys Gly Asn Leu Ala Leu Ser Gln Ala Phe Ser Lys Asp Ser 
    450                 455                 460                 


Phe Pro Lys Leu Arg Ile Leu Glu Val Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Pro Tyr Gly Met Cys Ala Ser Phe Phe Lys Ala Ser Gly Gln Trp Glu 
                485                 490                 495     


Ala Glu Asp Leu His Leu Asp Asp Glu Glu Ser Ser Lys Arg Pro Leu 
            500                 505                 510         


Gly Leu Leu Ala Arg Gln Ala Glu Asn His Tyr Asp Gln Asp Leu Asp 
        515                 520                 525             


Glu Leu Gln Leu Glu Met Glu Asp Ser Lys Pro His Pro Ser Val Gln 
    530                 535                 540                 


Cys Ser Pro Thr Pro Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu 
545                 550                 555                 560 


Ser Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val 
                565                 570                 575     


Leu Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val 
            580                 585                 590         


Pro Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn 
        595                 600                 605             


Thr Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu 
    610                 615                 620                 


Thr Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu 
625                 630                 635                 640 


Gly Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser 
                645                 650                 655     


Val Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser 
            660                 665                 670         


Cys Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala 
        675                 680                 685             


Gly Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro 
    690                 695                 700                 


Leu Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr 
705                 710                 715                 720 


Ala Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu 
                725                 730                 735     


Val Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile 
            740                 745                 750         


Lys Leu Tyr Cys Asp Leu Pro Arg Gly Asp Phe Glu Ala Val Trp Asp 
        755                 760                 765             


Cys Ala Met Val Arg His Val Ala Trp Leu Ile Phe Ala Asp Gly Leu 
    770                 775                 780                 


Leu Tyr Cys Pro Val Ala Phe Leu Ser Phe Ala Ser Met Leu Gly Leu 
785                 790                 795                 800 


Phe Pro Val Thr Pro Glu Ala Val Lys Ser Val Leu Leu Val Val Leu 
                805                 810                 815     


Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu Tyr Leu Leu Phe Asn Pro 
            820                 825                 830         


His Phe Arg Asp Asp Leu Arg Arg Leu Arg Pro Arg Ala Gly Asp Ser 
        835                 840                 845             


Gly Pro Leu Ala Tyr Ala Ala Ala Gly Glu Leu Glu Lys Ser Ser Cys 
    850                 855                 860                 


Asp Ser Thr Gln Ala Leu Val Ala Phe Ser Asp Val Asp Leu Ile Leu 
865                 870                 875                 880 


Glu Ala Ser Glu Ala Gly Arg Pro Pro Gly Leu Glu Thr Tyr Gly Phe 
                885                 890                 895     


Pro Ser Val Thr Leu Ile Ser Cys Gln Gln Pro Gly Ala Pro Arg Leu 
            900                 905                 910         


Glu Gly Ser His Cys Val Glu Pro Glu Gly Asn His Phe Gly Asn Pro 
        915                 920                 925             


Gln Pro Ser Met Asp Gly Glu Leu Leu Leu Arg Ala Glu Gly Ser Thr 
    930                 935                 940                 


Pro Ala Gly Gly Gly Leu Ser Gly Gly Gly Gly Phe Gln Pro Ser Gly 
945                 950                 955                 960 


Leu Ala Phe Ala Ser His Val 
                965         


<210>  6182
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LGSN__Homo_sapiens__NP_001137412

<400>  6182

Met Asn Asn Glu Glu Asp Leu Leu Gln Glu Asp Ser Thr Arg Asp Glu 
1               5                   10                  15      


Gly Asn Glu Thr Glu Ala Asn Ser Met Asn Thr Leu Arg Arg Thr Arg 
            20                  25                  30          


Lys Lys Val Thr Lys Pro Tyr Val Cys Ser Thr Glu Val Gly Glu Thr 
        35                  40                  45              


Asp Met Ser Asn Ser Asn Asp Cys Met Arg Asp Ser Ser Gln Ile Leu 
    50                  55                  60                  


Thr Pro Pro Gln Leu Ser Ser Arg Met Lys His Ile Arg Gln Ala Met 
65                  70                  75                  80  


Ala Lys Asn Arg Leu Gln Phe Val Arg Phe Glu Ala Thr Asp Leu His 
                85                  90                  95      


Gly Val Ser Arg Ser Lys Thr Ile Pro Ala His Phe Phe Gln Glu Lys 
            100                 105                 110         


Val Ser His Gly Val Cys Met Pro Arg Gly Tyr Leu Glu Val Ile Pro 
        115                 120                 125             


Asn Pro Lys Asp Asn Glu Met Asn Asn Ile Arg Ala Thr Cys Phe Asn 
    130                 135                 140                 


Ser Asp Ile Val Leu Met Pro Glu Leu Ser Thr Phe Arg Val Leu Pro 
145                 150                 155                 160 


Trp Ala Asp Arg Thr Ala Arg Val Ile Cys Asp Thr Phe Thr Val Thr 
                165                 170                 175     


Val Ser Gly Met Ser Ile Gly Arg Lys Thr Cys Ser Ala Ala Leu Leu 
            180                 185                 190         


Glu Leu Ser Ser Ser Arg Ser Leu Gly Lys Asn Gly Trp Gln Asp Ser 
        195                 200                 205             


<210>  6183
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHB__Homo_sapiens__NP_000885

<400>  6183

Met Glu Met Leu Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Ala Trp Ala Ser Arg Glu Pro Leu Arg Pro Trp Cys His Pro Ile 
            20                  25                  30          


Asn Ala Ile Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Met Arg Val 
    50                  55                  60                  


Leu Gln Ala Val Leu Pro Pro Leu Pro Gln Val Val Cys Thr Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asp Pro Val Val Ser Phe Pro Val Ala Leu Ser Cys Arg Cys Gly Pro 
            100                 105                 110         


Cys Arg Arg Ser Thr Ser Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp His Pro Gln Leu Ser Gly Leu Leu Phe Leu 
    130                 135                 140     


<210>  6184
<211>  699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHCGR__Homo_sapiens__NP_000224

<400>  6184

Met Lys Gln Arg Phe Ser Ala Leu Gln Leu Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Pro Pro Leu Pro Arg Ala Leu Arg Glu Ala Leu Cys Pro Glu 
            20                  25                  30          


Pro Cys Asn Cys Val Pro Asp Gly Ala Leu Arg Cys Pro Gly Pro Thr 
        35                  40                  45              


Ala Gly Leu Thr Arg Leu Ser Leu Ala Tyr Leu Pro Val Lys Val Ile 
    50                  55                  60                  


Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Ile Lys Ile Glu Ile 
65                  70                  75                  80  


Ser Gln Ile Asp Ser Leu Glu Arg Ile Glu Ala Asn Ala Phe Asp Asn 
                85                  90                  95      


Leu Leu Asn Leu Ser Glu Ile Leu Ile Gln Asn Thr Lys Asn Leu Arg 
            100                 105                 110         


Tyr Ile Glu Pro Gly Ala Phe Ile Asn Leu Pro Arg Leu Lys Tyr Leu 
        115                 120                 125             


Ser Ile Cys Asn Thr Gly Ile Arg Lys Phe Pro Asp Val Thr Lys Val 
    130                 135                 140                 


Phe Ser Ser Glu Ser Asn Phe Ile Leu Glu Ile Cys Asp Asn Leu His 
145                 150                 155                 160 


Ile Thr Thr Ile Pro Gly Asn Ala Phe Gln Gly Met Asn Asn Glu Ser 
                165                 170                 175     


Val Thr Leu Lys Leu Tyr Gly Asn Gly Phe Glu Glu Val Gln Ser His 
            180                 185                 190         


Ala Phe Asn Gly Thr Thr Leu Thr Ser Leu Glu Leu Lys Glu Asn Val 
        195                 200                 205             


His Leu Glu Lys Met His Asn Gly Ala Phe Arg Gly Ala Thr Gly Pro 
    210                 215                 220                 


Lys Thr Leu Asp Ile Ser Ser Thr Lys Leu Gln Ala Leu Pro Ser Tyr 
225                 230                 235                 240 


Gly Leu Glu Ser Ile Gln Arg Leu Ile Ala Thr Ser Ser Tyr Ser Leu 
                245                 250                 255     


Lys Lys Leu Pro Ser Arg Glu Thr Phe Val Asn Leu Leu Glu Ala Thr 
            260                 265                 270         


Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Arg Asn Leu Pro Thr Lys 
        275                 280                 285             


Glu Gln Asn Phe Ser His Ser Ile Ser Glu Asn Phe Ser Lys Gln Cys 
    290                 295                 300                 


Glu Ser Thr Val Arg Lys Val Asn Asn Lys Thr Leu Tyr Ser Ser Met 
305                 310                 315                 320 


Leu Ala Glu Ser Glu Leu Ser Gly Trp Asp Tyr Glu Tyr Gly Phe Cys 
                325                 330                 335     


Leu Pro Lys Thr Pro Arg Cys Ala Pro Glu Pro Asp Ala Phe Asn Pro 
            340                 345                 350         


Cys Glu Asp Ile Met Gly Tyr Asp Phe Leu Arg Val Leu Ile Trp Leu 
        355                 360                 365             


Ile Asn Ile Leu Ala Ile Met Gly Asn Met Thr Val Leu Phe Val Leu 
    370                 375                 380                 


Leu Thr Ser Arg Tyr Lys Leu Thr Val Pro Arg Phe Leu Met Cys Asn 
385                 390                 395                 400 


Leu Ser Phe Ala Asp Phe Cys Met Gly Leu Tyr Leu Leu Leu Ile Ala 
                405                 410                 415     


Ser Val Asp Ser Gln Thr Lys Gly Gln Tyr Tyr Asn His Ala Ile Asp 
            420                 425                 430         


Trp Gln Thr Gly Ser Gly Cys Ser Thr Ala Gly Phe Phe Thr Val Phe 
        435                 440                 445             


Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Val Ile Thr Leu Glu Arg 
    450                 455                 460                 


Trp His Thr Ile Thr Tyr Ala Ile His Leu Asp Gln Lys Leu Arg Leu 
465                 470                 475                 480 


Arg His Ala Ile Leu Ile Met Leu Gly Gly Trp Leu Phe Ser Ser Leu 
                485                 490                 495     


Ile Ala Met Leu Pro Leu Val Gly Val Ser Asn Tyr Met Lys Val Ser 
            500                 505                 510         


Ile Cys Phe Pro Met Asp Val Glu Thr Thr Leu Ser Gln Val Tyr Ile 
        515                 520                 525             


Leu Thr Ile Leu Ile Leu Asn Val Val Ala Phe Phe Ile Ile Cys Ala 
    530                 535                 540                 


Cys Tyr Ile Lys Ile Tyr Phe Ala Val Arg Asn Pro Glu Leu Met Ala 
545                 550                 555                 560 


Thr Asn Lys Asp Thr Lys Ile Ala Lys Lys Met Ala Ile Leu Ile Phe 
                565                 570                 575     


Thr Asp Phe Thr Cys Met Ala Pro Ile Ser Phe Phe Ala Ile Ser Ala 
            580                 585                 590         


Ala Phe Lys Val Pro Leu Ile Thr Val Thr Asn Ser Lys Val Leu Leu 
        595                 600                 605             


Val Leu Phe Tyr Pro Ile Asn Ser Cys Ala Asn Pro Phe Leu Tyr Ala 
    610                 615                 620                 


Ile Phe Thr Lys Thr Phe Gln Arg Asp Phe Phe Leu Leu Leu Ser Lys 
625                 630                 635                 640 


Phe Gly Cys Cys Lys Arg Arg Ala Glu Leu Tyr Arg Arg Lys Asp Phe 
                645                 650                 655     


Ser Ala Tyr Thr Ser Asn Cys Lys Asn Gly Phe Thr Gly Ser Asn Lys 
            660                 665                 670         


Pro Ser Gln Ser Thr Leu Lys Leu Ser Thr Leu His Cys Gln Gly Thr 
        675                 680                 685             


Ala Leu Leu Asp Lys Thr Arg Tyr Thr Glu Cys 
    690                 695                 


<210>  6185
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHFP__Homo_sapiens__XP_011533163

<400>  6185

Met Ala Ser Ser Leu Thr Cys Thr Gly Val Ile Trp Ala Leu Leu Ser 
1               5                   10                  15      


Phe Leu Cys Ala Ala Thr Ser Cys Val Gly Phe Phe Met Pro Tyr Trp 
            20                  25                  30          


Leu Trp Gly Ser Gln Leu Gly Lys Pro Val Ser Phe Gly Thr Phe Arg 
        35                  40                  45              


Arg Cys Ser Tyr Pro Val His Asp Glu Ser Arg Gln Met Met Val Met 
    50                  55                  60                  


Val Glu Glu Cys Gly Arg Tyr Ala Ser Phe Gln Gly Ile Pro Ser Ala 
65                  70                  75                  80  


Glu Trp Arg Ile Cys Thr Ile Val Thr Gly Leu Gly Cys Gly Leu Leu 
                85                  90                  95      


Leu Leu Val Ala Leu Thr Ala Leu Met Gly Cys Cys Val Ser Asp Leu 
            100                 105                 110         


Ile Ser Arg Thr Val Gly Arg Val Ala Gly Gly Ile Gln Phe Leu Gly 
        115                 120                 125             


Gly Leu Leu Ile Gly Ala Gly Cys Ala Leu Tyr Pro Leu Gly Trp Asp 
    130                 135                 140                 


Ser Glu Glu Val Arg Gln Thr Cys Gly Tyr Thr Ser Gly Gln Phe Asp 
145                 150                 155                 160 


Leu Gly Lys Cys Glu Ile Gly Trp Ala Tyr Tyr Cys Thr Gly Ala Gly 
                165                 170                 175     


Ala Thr Ala Ala Met Leu Leu Cys Thr Trp Leu Ala Cys Phe Ser Gly 
            180                 185                 190         


Lys Lys Gln Lys His Tyr Pro Tyr 
        195                 200 


<210>  6186
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHFPL1__Homo_sapiens__XP_011529245

<400>  6186

Met Val Thr Tyr Cys Ile Trp Cys Cys Asp Pro Thr His Leu Pro Ile 
1               5                   10                  15      


Pro Ala Glu Lys Pro Val Thr Met Arg Ser Ser Leu Thr Met Val Gly 
            20                  25                  30          


Thr Leu Trp Ala Phe Leu Ser Leu Val Thr Ala Val Thr Ser Ser Thr 
        35                  40                  45              


Ser Tyr Phe Leu Pro Tyr Trp Leu Phe Gly Ser Gln Met Gly Lys Pro 
    50                  55                  60                  


Val Ser Phe Ser Thr Phe Arg Arg Cys Asn Tyr Pro Val Arg Gly Glu 
65                  70                  75                  80  


Gly His Ser Leu Ile Met Val Glu Glu Cys Gly Arg Tyr Ala Ser Phe 
                85                  90                  95      


Asn Ala Ile Pro Ser Leu Ala Trp Gln Met Cys Thr Val Val Thr Gly 
            100                 105                 110         


Ala Gly Cys Ala Leu Leu Leu Leu Val Ala Leu Ala Ala Val Leu Gly 
        115                 120                 125             


Cys Cys Met Glu Glu Leu Ile Ser Arg Met Met Gly Arg Cys Met Gly 
    130                 135                 140                 


Ala Ala Gln Phe Val Gly Gly Leu Leu Ile Ser Ser Gly Cys Ala Leu 
145                 150                 155                 160 


Tyr Pro Leu Gly Trp Asn Ser Pro Glu Ile Met Gln Thr Cys Gly Asn 
                165                 170                 175     


Val Ser Asn Gln Phe Gln Leu Gly Thr Cys Arg Leu Gly Trp Ala Tyr 
            180                 185                 190         


Tyr Cys Ala Gly Gly Gly Ala Ala Ala Ala Met Leu Ile Cys Thr Trp 
        195                 200                 205             


Leu Ser Cys Phe Ala Gly Arg Asn Pro Lys Pro Val Ile Leu Val Glu 
    210                 215                 220                 


Ser Ile Met Arg Asn Thr Asn Ser Tyr Ala Met Glu Leu Asp His Cys 
225                 230                 235                 240 


Leu Lys Pro 
            


<210>  6187
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHFPL2__Homo_sapiens__NP_005770

<400>  6187

Met Cys His Val Ile Val Thr Cys Arg Ser Met Leu Trp Thr Leu Leu 
1               5                   10                  15      


Ser Ile Val Val Ala Phe Ala Glu Leu Ile Ala Phe Met Ser Ala Asp 
            20                  25                  30          


Trp Leu Ile Gly Lys Ala Arg Ser Arg Gly Gly Val Glu Pro Ala Gly 
        35                  40                  45              


Pro Gly Gly Gly Ser Pro Glu Pro Tyr His Pro Thr Leu Gly Ile Tyr 
    50                  55                  60                  


Ala Arg Cys Ile Arg Asn Pro Gly Val Gln His Phe Gln Arg Asp Thr 
65                  70                  75                  80  


Leu Cys Gly Pro Tyr Ala Glu Ser Phe Gly Glu Ile Ala Ser Gly Phe 
                85                  90                  95      


Trp Gln Ala Thr Ala Ile Phe Leu Ala Val Gly Ile Phe Ile Leu Cys 
            100                 105                 110         


Met Val Ala Leu Val Ser Val Phe Thr Met Cys Val Gln Ser Ile Met 
        115                 120                 125             


Lys Lys Ser Ile Phe Asn Val Cys Gly Leu Leu Gln Gly Ile Ala Gly 
    130                 135                 140                 


Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr Pro Ala Gly Trp Gly Cys 
145                 150                 155                 160 


Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr Ala Ser Ala Tyr Lys Pro 
                165                 170                 175     


Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr Thr Ala Ile Gly Gly Thr 
            180                 185                 190         


Val Leu Thr Phe Ile Cys Ala Val Phe Ser Ala Gln Ala Glu Ile Ala 
        195                 200                 205             


Thr Ser Ser Asp Lys Val Gln Glu Glu Ile Glu Glu Gly Lys Asn Leu 
    210                 215                 220                 


Ile Cys Leu Leu 
225             


<210>  6188
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHFPL3__Homo_sapiens__NP_945351

<400>  6188

Met Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Met Leu 
1               5                   10                  15      


Pro Ala Gln Glu Ala Ala Lys Leu Tyr His Thr Asn Tyr Val Arg Asn 
            20                  25                  30          


Ser Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys Phe Ala 
        35                  40                  45              


Ile Val Asn Val Val Cys Phe Ile Gln Pro Tyr Trp Ile Gly Asp Gly 
    50                  55                  60                  


Val Asp Thr Pro Gln Ala Gly Tyr Phe Gly Leu Phe His Tyr Cys Ile 
65                  70                  75                  80  


Gly Asn Gly Phe Ser Arg Glu Leu Thr Cys Arg Gly Ser Phe Thr Asp 
                85                  90                  95      


Phe Ser Thr Leu Pro Ser Gly Ala Phe Lys Ala Ala Ser Phe Phe Ile 
            100                 105                 110         


Gly Leu Ser Met Met Leu Ile Ile Ala Cys Ile Ile Cys Phe Thr Leu 
        115                 120                 125             


Phe Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys Ala Trp Met 
    130                 135                 140                 


Gln Leu Thr Ser Ala Ala Cys Leu Val Leu Gly Cys Met Ile Phe Pro 
145                 150                 155                 160 


Asp Gly Trp Asp Ser Asp Glu Val Lys Arg Met Cys Gly Glu Lys Thr 
                165                 170                 175     


Asp Lys Tyr Thr Leu Gly Ala Cys Ser Val Arg Trp Ala Tyr Ile Leu 
            180                 185                 190         


Ala Ile Ile Gly Ile Leu Asp Ala Leu Ile Leu Ser Phe Leu Ala Phe 
        195                 200                 205             


Val Leu Gly Asn Arg Gln Asp Ser Leu Met Ala Glu Glu Leu Lys Ala 
    210                 215                 220                 


Glu Asn Lys Val Leu Leu Ser Gln Tyr Ser Leu Glu 
225                 230                 235     


<210>  6189
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHFPL4__Homo_sapiens__XP_011531995

<400>  6189

Met Leu Pro Ser Gln Glu Ala Ser Lys Leu Tyr His Glu His Tyr Met 
1               5                   10                  15      


Arg Asn Ser Arg Ala Ile Gly Val Leu Trp Ala Ile Phe Thr Ile Cys 
            20                  25                  30          


Phe Ala Ile Ile Asn Val Val Val Phe Ile Gln Pro Tyr Trp Val Gly 
        35                  40                  45              


Asp Ser Val Ser Thr Pro Lys Pro Gly Tyr Phe Gly Leu Phe His Tyr 
    50                  55                  60                  


Cys Val Gly Ser Gly Leu Ala Gly Arg Glu Leu Thr Cys Arg Gly Ser 
65                  70                  75                  80  


Phe Thr Asp Phe Ser Thr Ile Pro Ser Ser Ala Phe Lys Ala Ala Ala 
                85                  90                  95      


Phe Phe Val Leu Leu Ser Met Val Leu Ile Leu Gly Cys Ile Thr Cys 
            100                 105                 110         


Phe Ser Leu Phe Phe Phe Cys Asn Thr Ala Thr Val Tyr Lys Ile Cys 
        115                 120                 125             


Ala Trp Met Gln Leu Leu Ala Ala Leu Cys Leu Val Leu Gly Cys Met 
    130                 135                 140                 


Ile Phe Pro Asp Gly Trp Asp Ala Glu Thr Ile Arg Asp Met Cys Gly 
145                 150                 155                 160 


Ala Lys Thr Gly Lys Tyr Ser Leu Gly Asp Cys Ser Val Arg Trp Ala 
                165                 170                 175     


Tyr Ile Leu Ala Ile Ile Gly Ile Leu Asn Ala Leu Ile Leu Ser Phe 
            180                 185                 190         


Leu Ala Phe Val Leu Gly Asn Arg Gln Thr Asp Leu Leu Gln Glu Glu 
        195                 200                 205             


Leu Lys Pro Glu Asn Lys Asp Phe Val Gly Ser Thr Val Ser Ser Val 
    210                 215                 220                 


Leu Arg Pro Gly Gly Asp Val Ser Gly Trp Gly Val Leu Pro Cys Pro 
225                 230                 235                 240 


Val Ala His Ser Gln Gly Pro 
                245         


<210>  6190
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHFPL5__Homo_sapiens__NP_872354

<400>  6190

Met Val Lys Leu Leu Pro Ala Gln Glu Ala Ala Lys Ile Tyr His Thr 
1               5                   10                  15      


Asn Tyr Val Arg Asn Ser Arg Ala Val Gly Val Met Trp Gly Thr Leu 
            20                  25                  30          


Thr Ile Cys Phe Ser Val Leu Val Met Ala Leu Phe Ile Gln Pro Tyr 
        35                  40                  45              


Trp Ile Gly Asp Ser Val Asn Thr Pro Gln Ala Gly Tyr Phe Gly Leu 
    50                  55                  60                  


Phe Ser Tyr Cys Val Gly Asn Val Leu Ser Ser Glu Leu Ile Cys Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Phe Ser Ser Ile Pro Ser Arg Ala Phe Lys Thr 
                85                  90                  95      


Ala Met Phe Phe Val Ala Leu Gly Met Phe Leu Ile Ile Gly Ser Ile 
            100                 105                 110         


Ile Cys Phe Ser Leu Phe Phe Ile Cys Asn Thr Ala Thr Val Tyr Lys 
        115                 120                 125             


Ile Cys Ala Trp Met Gln Leu Ala Ala Ala Thr Gly Leu Met Ile Gly 
    130                 135                 140                 


Cys Leu Val Tyr Pro Asp Gly Trp Asp Ser Ser Glu Val Arg Arg Met 
145                 150                 155                 160 


Cys Gly Glu Gln Thr Gly Lys Tyr Thr Leu Gly His Cys Thr Ile Arg 
                165                 170                 175     


Trp Ala Phe Met Leu Ala Ile Leu Ser Ile Gly Asp Ala Leu Ile Leu 
            180                 185                 190         


Ser Phe Leu Ala Phe Val Leu Gly Tyr Arg Gln Asp Lys Leu Leu Pro 
        195                 200                 205             


Asp Asp Tyr Lys Ala Asp Gly Thr Glu Glu Val 
    210                 215                 


<210>  6191
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHPP__Homo_sapiens__NP_001161352

<400>  6191

Met Ala Pro Trp Gly Lys Arg Leu Ala Gly Val Arg Gly Val Leu Leu 
1               5                   10                  15      


Asp Ile Ser Gly Val Leu Tyr Asp Ser Gly Ala Gly Gly Gly Thr Ala 
            20                  25                  30          


Ile Ala Gly Ser Val Glu Ala Val Ala Arg Leu Lys Arg Ser Arg Leu 
        35                  40                  45              


Lys Val Arg Phe Cys Thr Asn Glu Ser Gln Lys Ser Arg Ala Glu Leu 
    50                  55                  60                  


Val Gly Gln Leu Gln Arg Leu Gly Phe Asp Ile Ser Glu Gln Glu Val 
65                  70                  75                  80  


Thr Ala Pro Ala Pro Ala Ala Cys Gln Ile Leu Lys Glu Gln Gly Leu 
                85                  90                  95      


Arg Pro Tyr Leu Leu Ile His Asp Gly Val Arg Ser Glu Phe Asp Gln 
            100                 105                 110         


Ile Asp Thr Ser Asn Pro Asn Cys Val Val Ile Ala Asp Ala Gly Glu 
        115                 120                 125             


Ser Phe Ser Tyr Gln Asn Met Asn Asn Ala Phe Gln Val Leu Met Glu 
    130                 135                 140                 


Leu Glu Lys Pro Val Leu Ile Ser Leu Gly Lys Gly Arg Tyr Tyr Lys 
145                 150                 155                 160 


Glu Thr Ser Gly Leu Met Leu Asp Val Gly Pro Tyr Met Lys Ala Leu 
                165                 170                 175     


Glu Tyr Ala Cys Gly Ile Lys Ala Glu Val Val Gly Lys Pro Ser Pro 
            180                 185                 190         


Glu Phe Phe Lys Ser Ala Leu Gln Ala Ile Gly Val Glu Ala His Gln 
        195                 200                 205             


Ala Gln 
    210 


<210>  6192
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHX1__Homo_sapiens__XP_011545112

<400>  6192

Met Val His Cys Ala Gly Cys Lys Arg Pro Ile Leu Asp Arg Phe Leu 
1               5                   10                  15      


Leu Asn Val Leu Asp Arg Ala Trp His Val Lys Cys Val Gln Cys Cys 
            20                  25                  30          


Glu Cys Lys Cys Asn Leu Thr Glu Lys Cys Phe Ser Arg Glu Gly Lys 
        35                  40                  45              


Leu Tyr Cys Lys Asn Asp Phe Phe Arg Cys Phe Gly Thr Lys Cys Ala 
    50                  55                  60                  


Gly Cys Ala Gln Gly Ile Ser Pro Ser Asp Leu Val Arg Arg Ala Arg 
65                  70                  75                  80  


Ser Lys Val Phe His Leu Asn Cys Phe Thr Cys Met Met Cys Asn Lys 
                85                  90                  95      


Gln Leu Ser Thr Gly Glu Glu Leu Tyr Ile Ile Asp Glu Asn Lys Phe 
            100                 105                 110         


Val Cys Lys Glu Asp Tyr Leu Ser Asn Ser Ser Val Ala Lys Glu Asn 
        115                 120                 125             


Ser Leu His Ser Ala Thr Thr Gly Ser Asp Pro Ser Leu Ser Pro Asp 
    130                 135                 140                 


Ser Gln Asp Pro Ser Gln Asp Asp Ala Lys Asp Ser Glu Ser Ala Asn 
145                 150                 155                 160 


Val Ser Asp Lys Glu Ala Gly Ser Asn Glu Asn Asp Asp Gln Asn Leu 
                165                 170                 175     


Gly Ala Lys Arg Arg Gly Pro Arg Thr Thr Ile Lys Ala Lys Gln Leu 
            180                 185                 190         


Glu Thr Leu Lys Ala Ala Phe Ala Ala Thr Pro Lys Pro Thr Arg His 
        195                 200                 205             


Ile Arg Glu Gln Leu Ala Gln Glu Thr Gly Leu Asn Met Arg Val Ile 
    210                 215                 220                 


Gln Val Trp Phe Gln Asn Arg Arg Ser Lys Glu Arg Arg Met Lys Gln 
225                 230                 235                 240 


Leu Ser Ala Leu Gly Ala Arg Arg His Ala Phe Phe Arg Ser Pro Arg 
                245                 250                 255     


Arg Met Arg Pro Leu Val Asp Arg Leu Glu Pro Gly Glu Leu Ile Pro 
            260                 265                 270         


Asn Gly Pro Phe Ser Phe Tyr Gly Asp Tyr Gln Ser Glu Tyr Tyr Gly 
        275                 280                 285             


Pro Gly Gly Asn Tyr Asp Phe Phe Pro Gln Gly Pro Pro Ser Ser Gln 
    290                 295                 300                 


Ala Gln Thr Pro Val Asp Leu Pro Phe Val Pro Ser Ser Gly Pro Ser 
305                 310                 315                 320 


Gly Thr Pro Leu Gly Gly Leu Glu His Pro Leu Pro Gly His His Pro 
                325                 330                 335     


Ser Ser Glu Ala Gln Arg Phe Thr Asp Ile Leu Ala His Pro Pro Gly 
            340                 345                 350         


Asp Ser Pro Ser Pro Glu Pro Ser Leu Pro Gly Pro Leu His Ser Met 
        355                 360                 365             


Ser Ala Glu Val Phe Gly Pro Ser Pro Pro Phe Ser Ser Leu Ser Val 
    370                 375                 380                 


Asn Gly Gly Ala Ser Tyr Gly Asn His Leu Ser His Pro Pro Glu Met 
385                 390                 395                 400 


Asn Glu Ala Ala Val Trp 
                405     


<210>  6193
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHX2__Homo_sapiens__NP_004780

<400>  6193

Met Leu Phe His Ser Leu Ser Gly Pro Glu Val His Gly Val Ile Asp 
1               5                   10                  15      


Glu Met Asp Arg Arg Ala Lys Ser Glu Ala Pro Ala Ile Ser Ser Ala 
            20                  25                  30          


Ile Asp Arg Gly Asp Thr Glu Thr Thr Met Pro Ser Ile Ser Ser Asp 
        35                  40                  45              


Arg Ala Ala Leu Cys Ala Gly Cys Gly Gly Lys Ile Ser Asp Arg Tyr 
    50                  55                  60                  


Tyr Leu Leu Ala Val Asp Lys Gln Trp His Met Arg Cys Leu Lys Cys 
65                  70                  75                  80  


Cys Glu Cys Lys Leu Asn Leu Glu Ser Glu Leu Thr Cys Phe Ser Lys 
                85                  90                  95      


Asp Gly Ser Ile Tyr Cys Lys Glu Asp Tyr Tyr Arg Arg Phe Ser Val 
            100                 105                 110         


Gln Arg Cys Ala Arg Cys His Leu Gly Ile Ser Ala Ser Glu Met Val 
        115                 120                 125             


Met Arg Ala Arg Asp Leu Val Tyr His Leu Asn Cys Phe Thr Cys Thr 
    130                 135                 140                 


Thr Cys Asn Lys Met Leu Thr Thr Gly Asp His Phe Gly Met Lys Asp 
145                 150                 155                 160 


Ser Leu Val Tyr Cys Arg Leu His Phe Glu Ala Leu Leu Gln Gly Glu 
                165                 170                 175     


Tyr Pro Ala His Phe Asn His Ala Asp Val Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Ala Ala Lys Ser Ala Gly Leu Gly Ala Ala Gly Ala Asn Pro 
        195                 200                 205             


Leu Gly Leu Pro Tyr Tyr Asn Gly Val Gly Thr Val Gln Lys Gly Arg 
    210                 215                 220                 


Pro Arg Lys Arg Lys Ser Pro Gly Pro Gly Ala Asp Leu Ala Ala Tyr 
225                 230                 235                 240 


Asn Ala Ala Leu Ser Cys Asn Glu Asn Asp Ala Glu His Leu Asp Arg 
                245                 250                 255     


Asp Gln Pro Tyr Pro Ser Ser Gln Lys Thr Lys Arg Met Arg Thr Ser 
            260                 265                 270         


Phe Lys His His Gln Leu Arg Thr Met Lys Ser Tyr Phe Ala Ile Asn 
        275                 280                 285             


His Asn Pro Asp Ala Lys Asp Leu Lys Gln Leu Ala Gln Lys Thr Gly 
    290                 295                 300                 


Leu Thr Lys Arg Val Leu Gln Val Trp Phe Gln Asn Ala Arg Ala Lys 
305                 310                 315                 320 


Phe Arg Arg Asn Leu Leu Arg Gln Glu Asn Thr Gly Val Asp Lys Ser 
                325                 330                 335     


Thr Asp Ala Ala Leu Gln Thr Gly Thr Pro Ser Gly Pro Ala Ser Glu 
            340                 345                 350         


Leu Ser Asn Ala Ser Leu Ser Pro Ser Ser Thr Pro Thr Thr Leu Thr 
        355                 360                 365             


Asp Leu Thr Ser Pro Thr Leu Pro Thr Val Thr Ser Val Leu Thr Ser 
    370                 375                 380                 


Val Pro Gly Asn Leu Glu Gly His Glu Pro His Ser Pro Ser Gln Thr 
385                 390                 395                 400 


Thr Leu Thr Asn Leu Phe 
                405     


<210>  6194
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHX3__Homo_sapiens__NP_055379

<400>  6194

Met Glu Ala Arg Gly Glu Leu Gly Pro Ala Arg Glu Ser Ala Gly Gly 
1               5                   10                  15      


Asp Leu Leu Leu Ala Leu Leu Ala Arg Arg Ala Asp Leu Arg Arg Glu 
            20                  25                  30          


Ile Pro Leu Cys Ala Gly Cys Asp Gln His Ile Leu Asp Arg Phe Ile 
        35                  40                  45              


Leu Lys Ala Leu Asp Arg His Trp His Ser Lys Cys Leu Lys Cys Ser 
    50                  55                  60                  


Asp Cys His Thr Pro Leu Ala Glu Arg Cys Phe Ser Arg Gly Glu Ser 
65                  70                  75                  80  


Val Tyr Cys Lys Asp Asp Phe Phe Lys Arg Phe Gly Thr Lys Cys Ala 
                85                  90                  95      


Ala Cys Gln Leu Gly Ile Pro Pro Thr Gln Val Val Arg Arg Ala Gln 
            100                 105                 110         


Asp Phe Val Tyr His Leu His Cys Phe Ala Cys Val Val Cys Lys Arg 
        115                 120                 125             


Gln Leu Ala Thr Gly Asp Glu Phe Tyr Leu Met Glu Asp Ser Arg Leu 
    130                 135                 140                 


Val Cys Lys Ala Asp Tyr Glu Thr Ala Lys Gln Arg Glu Ala Glu Ala 
145                 150                 155                 160 


Thr Ala Lys Arg Pro Arg Thr Thr Ile Thr Ala Lys Gln Leu Glu Thr 
                165                 170                 175     


Leu Lys Ser Ala Tyr Asn Thr Ser Pro Lys Pro Ala Arg His Val Arg 
            180                 185                 190         


Glu Gln Leu Ser Ser Glu Thr Gly Leu Asp Met Arg Val Val Gln Val 
        195                 200                 205             


Trp Phe Gln Asn Arg Arg Ala Lys Glu Lys Arg Leu Lys Lys Asp Ala 
    210                 215                 220                 


Gly Arg Gln Arg Trp Gly Gln Tyr Phe Arg Asn Met Lys Arg Ser Arg 
225                 230                 235                 240 


Gly Gly Ser Lys Ser Asp Lys Asp Ser Val Gln Glu Gly Gln Asp Ser 
                245                 250                 255     


Asp Ala Glu Val Ser Phe Pro Asp Glu Pro Ser Leu Ala Glu Met Gly 
            260                 265                 270         


Pro Ala Asn Gly Leu Tyr Gly Ser Leu Gly Glu Pro Thr Gln Ala Leu 
        275                 280                 285             


Gly Arg Pro Ser Gly Ala Leu Gly Asn Phe Ser Leu Glu His Gly Gly 
    290                 295                 300                 


Leu Ala Gly Pro Glu Gln Tyr Arg Glu Leu Arg Pro Gly Ser Pro Tyr 
305                 310                 315                 320 


Gly Val Pro Pro Ser Pro Ala Ala Pro Gln Ser Leu Pro Gly Pro Gln 
                325                 330                 335     


Pro Leu Leu Ser Ser Leu Val Tyr Pro Asp Thr Ser Leu Gly Leu Val 
            340                 345                 350         


Pro Ser Gly Ala Pro Gly Gly Pro Pro Pro Met Arg Val Leu Ala Gly 
        355                 360                 365             


Asn Gly Pro Ser Ser Asp Leu Ser Thr Gly Ser Ser Gly Gly Tyr Pro 
    370                 375                 380                 


Asp Phe Pro Ala Ser Pro Ala Ser Trp Leu Asp Glu Val Asp His Ala 
385                 390                 395                 400 


Gln Phe 
        


<210>  6195
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHX4__Homo_sapiens__NP_203129

<400>  6195

Met Met Gln Ser Ala Thr Val Pro Ala Glu Gly Ala Val Lys Gly Leu 
1               5                   10                  15      


Pro Glu Met Leu Gly Val Pro Met Gln Gln Ile Pro Gln Cys Ala Gly 
            20                  25                  30          


Cys Asn Gln His Ile Leu Asp Lys Phe Ile Leu Lys Val Leu Asp Arg 
        35                  40                  45              


His Trp His Ser Ser Cys Leu Lys Cys Ala Asp Cys Gln Met Gln Leu 
    50                  55                  60                  


Ala Asp Arg Cys Phe Ser Arg Ala Gly Ser Val Tyr Cys Lys Glu Asp 
65                  70                  75                  80  


Phe Phe Lys Arg Phe Gly Thr Lys Cys Thr Ala Cys Gln Gln Gly Ile 
                85                  90                  95      


Pro Pro Thr Gln Val Val Arg Lys Ala Gln Asp Phe Val Tyr His Leu 
            100                 105                 110         


His Cys Phe Ala Cys Ile Ile Cys Asn Arg Gln Leu Ala Thr Gly Asp 
        115                 120                 125             


Glu Phe Tyr Leu Met Glu Asp Gly Arg Leu Val Cys Lys Glu Asp Tyr 
    130                 135                 140                 


Glu Thr Ala Lys Gln Asn Asp Asp Ser Glu Ala Gly Ala Lys Arg Pro 
145                 150                 155                 160 


Arg Thr Thr Ile Thr Ala Lys Gln Leu Glu Thr Leu Lys Asn Ala Tyr 
                165                 170                 175     


Lys Asn Ser Pro Lys Pro Ala Arg His Val Arg Glu Gln Leu Ser Ser 
            180                 185                 190         


Glu Thr Gly Leu Asp Met Arg Val Val Gln Val Trp Phe Gln Asn Arg 
        195                 200                 205             


Arg Ala Lys Glu Lys Arg Leu Lys Lys Asp Ala Gly Arg His Arg Trp 
    210                 215                 220                 


Gly Gln Phe Tyr Lys Ser Val Lys Arg Ser Arg Gly Ser Ser Lys Gln 
225                 230                 235                 240 


Glu Lys Glu Ser Ser Ala Glu Asp Cys Gly Val Ser Asp Ser Glu Leu 
                245                 250                 255     


Ser Phe Arg Glu Asp Gln Ile Leu Ser Glu Leu Gly His Thr Asn Arg 
            260                 265                 270         


Ile Tyr Gly Asn Val Gly Asp Val Thr Gly Gly Gln Leu Met Asn Gly 
        275                 280                 285             


Ser Phe Ser Met Asp Gly Thr Gly Gln Ser Tyr Gln Asp Leu Arg Asp 
    290                 295                 300                 


Gly Ser Pro Tyr Gly Ile Pro Gln Ser Pro Ser Ser Ile Ser Ser Leu 
305                 310                 315                 320 


Pro Ser His Ala Pro Leu Leu Asn Gly Leu Asp Tyr Thr Val Asp Ser 
                325                 330                 335     


Asn Leu Gly Ile Ile Ala His Ala Gly Gln Gly Val Ser Gln Thr Leu 
            340                 345                 350         


Arg Ala Met Ala Gly Gly Pro Thr Ser Asp Ile Ser Thr Gly Ser Ser 
        355                 360                 365             


Val Gly Tyr Pro Asp Phe Pro Thr Ser Pro Gly Ser Trp Leu Asp Glu 
    370                 375                 380                 


Met Asp His Pro Pro Phe 
385                 390 


<210>  6196
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHX5__Homo_sapiens__NP_071758

<400>  6196

Met Met Val His Cys Ala Gly Cys Glu Arg Pro Ile Leu Asp Arg Phe 
1               5                   10                  15      


Leu Leu Asn Val Leu Asp Arg Ala Trp His Ile Lys Cys Val Gln Cys 
            20                  25                  30          


Cys Glu Cys Lys Thr Asn Leu Ser Glu Lys Cys Phe Ser Arg Glu Gly 
        35                  40                  45              


Lys Leu Tyr Cys Lys Asn Asp Phe Phe Arg Arg Phe Gly Thr Lys Cys 
    50                  55                  60                  


Ala Gly Cys Ala Gln Gly Ile Ser Pro Ser Asp Leu Val Arg Lys Ala 
65                  70                  75                  80  


Arg Ser Lys Val Phe His Leu Asn Cys Phe Thr Cys Met Val Cys Asn 
                85                  90                  95      


Lys Gln Leu Ser Thr Gly Glu Glu Leu Tyr Val Ile Asp Glu Asn Lys 
            100                 105                 110         


Phe Val Cys Lys Asp Asp Tyr Leu Ser Ser Ser Ser Leu Lys Glu Gly 
        115                 120                 125             


Ser Leu Asn Ser Val Ser Ser Cys Thr Asp Arg Ser Leu Ser Pro Asp 
    130                 135                 140                 


Leu Gln Asp Ala Leu Gln Asp Asp Pro Lys Glu Thr Asp Asn Ser Thr 
145                 150                 155                 160 


Ser Ser Asp Lys Glu Thr Ala Asn Asn Glu Asn Glu Glu Gln Asn Ser 
                165                 170                 175     


Gly Thr Lys Arg Arg Gly Pro Arg Thr Thr Ile Lys Ala Lys Gln Leu 
            180                 185                 190         


Glu Thr Leu Lys Ala Ala Phe Ala Ala Thr Pro Lys Pro Thr Arg His 
        195                 200                 205             


Ile Arg Glu Gln Leu Ala Gln Glu Thr Gly Leu Asn Met Arg Val Ile 
    210                 215                 220                 


Gln Val Trp Phe Gln Asn Arg Arg Ser Lys Glu Arg Arg Met Lys Gln 
225                 230                 235                 240 


Leu Ser Ala Leu Gly Ala Arg Arg His Ala Phe Phe Arg Ser Pro Arg 
                245                 250                 255     


Arg Met Arg Pro Leu Gly Gly Arg Leu Asp Glu Ser Glu Met Leu Gly 
            260                 265                 270         


Ser Thr Pro Tyr Thr Tyr Tyr Gly Asp Tyr Gln Gly Asp Tyr Tyr Ala 
        275                 280                 285             


Pro Gly Ser Asn Tyr Asp Phe Phe Ala His Gly Pro Pro Ser Gln Ala 
    290                 295                 300                 


Gln Ser Pro Ala Asp Ser Ser Phe Leu Ala Ala Ser Gly Pro Gly Ser 
305                 310                 315                 320 


Thr Pro Leu Gly Ala Leu Glu Pro Pro Leu Ala Gly Pro His Ala Ala 
                325                 330                 335     


Asp Asn Pro Arg Phe Thr Asp Met Ile Ser His Pro Asp Thr Pro Ser 
            340                 345                 350         


Pro Glu Pro Gly Leu Pro Gly Thr Leu His Pro Met Pro Gly Glu Val 
        355                 360                 365             


Phe Ser Gly Gly Pro Ser Pro Pro Phe Pro Met Ser Gly Thr Ser Gly 
    370                 375                 380                 


Tyr Ser Gly Pro Leu Ser His Pro Asn Pro Glu Leu Asn Glu Ala Ala 
385                 390                 395                 400 


Val Trp 
        


<210>  6197
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHX6__Homo_sapiens__NP_001229262

<400>  6197

Met Arg Arg Gly Leu Cys Arg Arg Ser Ala Glu Asn Pro Asp Ala Gly 
1               5                   10                  15      


Pro Val Met Ala Gln Pro Gly Ser Gly Cys Lys Ala Thr Thr Arg Cys 
            20                  25                  30          


Leu Glu Gly Thr Ala Pro Pro Ala Met Ala Gln Ser Asp Ala Glu Ala 
        35                  40                  45              


Leu Ala Gly Ala Leu Asp Lys Asp Glu Gly Gln Ala Ser Pro Cys Thr 
    50                  55                  60                  


Pro Ser Thr Pro Ser Val Cys Ser Pro Pro Ser Ala Ala Ser Ser Val 
65                  70                  75                  80  


Pro Ser Ala Gly Lys Asn Ile Cys Ser Ser Cys Gly Leu Glu Ile Leu 
                85                  90                  95      


Asp Arg Tyr Leu Leu Lys Val Asn Asn Leu Ile Trp His Val Arg Cys 
            100                 105                 110         


Leu Glu Cys Ser Val Cys Arg Thr Ser Leu Arg Gln Gln Asn Ser Cys 
        115                 120                 125             


Tyr Ile Lys Asn Lys Glu Ile Phe Cys Lys Met Asp Tyr Phe Ser Arg 
    130                 135                 140                 


Phe Gly Thr Lys Cys Ala Arg Cys Gly Arg Gln Ile Tyr Ala Ser Asp 
145                 150                 155                 160 


Trp Val Arg Arg Ala Arg Gly Asn Ala Tyr His Leu Ala Cys Phe Ala 
                165                 170                 175     


Cys Phe Ser Cys Lys Arg Gln Leu Ser Thr Gly Glu Glu Phe Gly Leu 
            180                 185                 190         


Val Glu Glu Lys Val Leu Cys Arg Ile His Tyr Asp Thr Met Ile Glu 
        195                 200                 205             


Asn Leu Lys Arg Ala Ala Glu Asn Gly Asn Gly Leu Thr Leu Glu Gly 
    210                 215                 220                 


Ala Val Pro Ser Glu Gln Asp Ser Gln Pro Lys Pro Ala Lys Arg Ala 
225                 230                 235                 240 


Arg Thr Ser Phe Thr Ala Glu Gln Leu Gln Val Met Gln Ala Gln Phe 
                245                 250                 255     


Ala Gln Asp Asn Asn Pro Asp Ala Gln Thr Leu Gln Lys Leu Ala Asp 
            260                 265                 270         


Met Thr Gly Leu Ser Arg Arg Val Ile Gln Val Trp Phe Gln Asn Cys 
        275                 280                 285             


Arg Ala Arg His Lys Lys His Thr Pro Gln His Pro Val Pro Pro Ser 
    290                 295                 300                 


Gly Ala Pro Pro Ser Arg Leu Pro Ser Ala Leu Ser Asp Asp Ile His 
305                 310                 315                 320 


Tyr Thr Pro Phe Ser Ser Pro Glu Arg Ala Arg Met Val Thr Leu His 
                325                 330                 335     


Gly Tyr Ile Glu Ser His Pro Phe Ser Val Leu Thr Leu Pro Ala Leu 
            340                 345                 350         


Pro His Leu Pro Val Gly Ala Pro Gln Leu Pro Leu Ser Arg 
        355                 360                 365     


<210>  6198
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHX9__Homo_sapiens__NP_001014434

<400>  6198

Met Leu Asn Gly Thr Thr Leu Glu Ala Ala Met Leu Phe His Gly Ile 
1               5                   10                  15      


Ser Gly Gly His Ile Gln Gly Ile Met Glu Glu Met Glu Arg Arg Ser 
            20                  25                  30          


Lys Thr Glu Ala Arg Leu Ala Lys Gly Ala Gln Leu Asn Gly Arg Asp 
        35                  40                  45              


Ala Gly Met Pro Pro Leu Ser Pro Glu Lys Pro Ala Leu Cys Ala Gly 
    50                  55                  60                  


Cys Gly Gly Lys Ile Ser Asp Arg Tyr Tyr Leu Leu Ala Val Asp Lys 
65                  70                  75                  80  


Gln Trp His Leu Arg Cys Leu Lys Cys Cys Glu Cys Lys Leu Ala Leu 
                85                  90                  95      


Glu Ser Glu Leu Thr Cys Phe Ala Lys Asp Gly Ser Ile Tyr Cys Lys 
            100                 105                 110         


Glu Asp Tyr Tyr Arg Arg Phe Ser Val Gln Arg Cys Ala Arg Cys His 
        115                 120                 125             


Leu Gly Ile Ser Ala Ser Glu Met Val Met Arg Ala Arg Asp Ser Val 
    130                 135                 140                 


Tyr His Leu Ser Cys Phe Thr Cys Ser Thr Cys Asn Lys Thr Leu Thr 
145                 150                 155                 160 


Thr Gly Asp His Phe Gly Met Lys Asp Ser Leu Val Tyr Cys Arg Ala 
                165                 170                 175     


His Phe Glu Thr Leu Leu Gln Gly Glu Tyr Pro Pro Gln Leu Ser Tyr 
            180                 185                 190         


Thr Glu Leu Ala Ala Lys Ser Gly Gly Leu Ala Leu Pro Tyr Phe Asn 
        195                 200                 205             


Gly Thr Gly Thr Val Gln Lys Gly Arg Pro Arg Lys Arg Lys Ser Pro 
    210                 215                 220                 


Ala Leu Gly Val Asp Ile Val Asn Tyr Asn Ser Gly Cys Asn Glu Asn 
225                 230                 235                 240 


Glu Ala Asp His Leu Asp Arg Asp Gln Gln Pro Tyr Pro Pro Ser Gln 
                245                 250                 255     


Lys Thr Lys Arg Met Arg Thr Ser Phe Lys His His Gln Leu Arg Thr 
            260                 265                 270         


Met Lys Ser Tyr Phe Ala Ile Asn His Asn Pro Asp Ala Lys Asp Leu 
        275                 280                 285             


Lys Gln Leu Ala Gln Lys Thr Gly Leu Thr Lys Arg Val Leu Gln Val 
    290                 295                 300                 


Trp Phe Gln Asn Ala Arg Ala Lys Phe Arg Arg Asn Leu Leu Arg Gln 
305                 310                 315                 320 


Glu Asn Gly Gly Val Asp Lys Ala Asp Gly Thr Ser Leu Pro Ala Pro 
                325                 330                 335     


Pro Ser Ala Asp Ser Gly Ala Leu Thr Pro Pro Gly Thr Ala Thr Thr 
            340                 345                 350         


Leu Thr Asp Leu Thr Asn Pro Thr Ile Thr Val Val Thr Ser Val Thr 
        355                 360                 365             


Ser Asn Met Asp Ser His Glu Ser Gly Ser Pro Ser Gln Thr Thr Leu 
    370                 375                 380                 


Thr Asn Leu Phe 
385             


<210>  6199
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIAS__Homo_sapiens__NP_006850

<400>  6199

Met Ser Leu Arg Cys Gly Asp Ala Ala Arg Thr Leu Gly Pro Arg Val 
1               5                   10                  15      


Phe Gly Arg Tyr Phe Cys Ser Pro Val Arg Pro Leu Ser Ser Leu Pro 
            20                  25                  30          


Asp Lys Lys Lys Glu Leu Leu Gln Asn Gly Pro Asp Leu Gln Asp Phe 
        35                  40                  45              


Val Ser Gly Asp Leu Ala Asp Arg Ser Thr Trp Asp Glu Tyr Lys Gly 
    50                  55                  60                  


Asn Leu Lys Arg Gln Lys Gly Glu Arg Leu Arg Leu Pro Pro Trp Leu 
65                  70                  75                  80  


Lys Thr Glu Ile Pro Met Gly Lys Asn Tyr Asn Lys Leu Lys Asn Thr 
                85                  90                  95      


Leu Arg Asn Leu Asn Leu His Thr Val Cys Glu Glu Ala Arg Cys Pro 
            100                 105                 110         


Asn Ile Gly Glu Cys Trp Gly Gly Gly Glu Tyr Ala Thr Ala Thr Ala 
        115                 120                 125             


Thr Ile Met Leu Met Gly Asp Thr Cys Thr Arg Gly Cys Arg Phe Cys 
    130                 135                 140                 


Ser Val Lys Thr Ala Arg Asn Pro Pro Pro Leu Asp Ala Ser Glu Pro 
145                 150                 155                 160 


Tyr Asn Thr Ala Lys Ala Ile Ala Glu Trp Gly Leu Asp Tyr Val Val 
                165                 170                 175     


Leu Thr Ser Val Asp Arg Asp Asp Met Pro Asp Gly Gly Ala Glu His 
            180                 185                 190         


Ile Ala Lys Thr Val Ser Tyr Leu Lys Glu Arg Asn Pro Lys Ile Leu 
        195                 200                 205             


Val Glu Cys Leu Thr Pro Asp Phe Arg Gly Asp Leu Lys Ala Ile Glu 
    210                 215                 220                 


Lys Val Ala Leu Ser Gly Leu Asp Val Tyr Ala His Asn Val Glu Thr 
225                 230                 235                 240 


Val Pro Glu Leu Gln Ser Lys Val Arg Asp Pro Arg Ala Asn Phe Asp 
                245                 250                 255     


Gln Ser Leu Arg Val Leu Lys His Ala Lys Lys Val Gln Pro Asp Val 
            260                 265                 270         


Ile Ser Lys Thr Ser Ile Met Leu Gly Leu Gly Glu Asn Asp Glu Gln 
        275                 280                 285             


Val Tyr Ala Thr Met Lys Ala Leu Arg Glu Ala Asp Val Asp Cys Leu 
    290                 295                 300                 


Thr Leu Gly Gln Tyr Met Gln Pro Thr Arg Arg His Leu Lys Val Glu 
305                 310                 315                 320 


Glu Tyr Ile Thr Pro Glu Lys Phe Lys Tyr Trp Glu Lys Val Gly Asn 
                325                 330                 335     


Glu Leu Gly Phe His Tyr Thr Ala Ser Gly Pro Leu Val Arg Ser Ser 
            340                 345                 350         


Tyr Lys Ala Gly Glu Phe Phe Leu Lys Asn Leu Val Ala Lys Arg Lys 
        355                 360                 365             


Thr Lys Asp Leu 
    370         


<210>  6200
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIF__Homo_sapiens__XP_011528474

<400>  6200

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 
        195                 200         


<210>  6201
<211>  1097
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIFR__Homo_sapiens__XP_011512344

<400>  6201

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  6202
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIG1__Homo_sapiens__NP_001275992

<400>  6202

Met Gln Arg Ser Ile Met Ala Ala Leu Lys Glu Trp Asn Gly Val Val 
1               5                   10                  15      


Ser Glu Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg 
            20                  25                  30          


Val Leu Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala 
        35                  40                  45              


Lys Gly Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg 
    50                  55                  60                  


Pro Ala Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro 
65                  70                  75                  80  


Met Asp Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys 
                85                  90                  95      


Gln Leu Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu 
            100                 105                 110         


Asp Glu Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Thr 
        115                 120                 125             


Pro Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly 
    130                 135                 140                 


Glu Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser 
145                 150                 155                 160 


Lys Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr 
                165                 170                 175     


Lys Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg 
            180                 185                 190         


Ala Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val 
        195                 200                 205             


Lys Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly 
    210                 215                 220                 


Ala Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn 
225                 230                 235                 240 


Asn Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val 
                245                 250                 255     


Pro Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser 
            260                 265                 270         


Ala Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val 
        275                 280                 285             


Val Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu 
    290                 295                 300                 


Asn His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp 
305                 310                 315                 320 


Gly Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu 
                325                 330                 335     


Ser Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala 
            340                 345                 350         


Glu Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu 
        355                 360                 365             


Thr Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr 
    370                 375                 380                 


Gly Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe 
385                 390                 395                 400 


Val Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser 
                405                 410                 415     


Gly Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu 
            420                 425                 430         


Ser Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala 
        435                 440                 445             


Met Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp 
    450                 455                 460                 


Leu Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro 
465                 470                 475                 480 


Asp Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg 
                485                 490                 495     


Leu Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met 
            500                 505                 510         


Leu Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu 
        515                 520                 525             


Glu Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln 
    530                 535                 540                 


Ile His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln 
545                 550                 555                 560 


Glu Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys 
                565                 570                 575     


Ile Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val 
            580                 585                 590         


Ala Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr 
        595                 600                 605             


Thr Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val 
    610                 615                 620                 


Cys Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val 
625                 630                 635                 640 


Arg Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val 
                645                 650                 655     


Glu Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp 
            660                 665                 670         


Ile Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys 
        675                 680                 685             


Glu Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile 
    690                 695                 700                 


Ala Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp 
705                 710                 715                 720 


Gly Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly 
                725                 730                 735     


Arg Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr 
            740                 745                 750         


Asp Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly 
        755                 760                 765             


Phe Ser Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala Leu 
    770                 775                 780                 


Val Leu Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile 
785                 790                 795                 800 


Pro Asp His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala 
                805                 810                 815     


Asp Leu Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp 
            820                 825                 830         


Ser Asp Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg 
        835                 840                 845             


Glu Asp Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys 
    850                 855                 860                 


Leu Tyr Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser 
865                 870                 875                 880 


Gly Ser Asp Pro Glu Asp Thr Tyr 
                885             


<210>  6203
<211>  1018
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIG3__Homo_sapiens__XP_005258027

<400>  6203

Met Ser Lys Phe Arg Gly Leu Arg Tyr Met Ser Leu Ala Phe Lys Ile 
1               5                   10                  15      


Phe Phe Pro Gln Thr Leu Arg Ala Leu Ser Arg Lys Glu Leu Cys Leu 
            20                  25                  30          


Phe Arg Lys His His Trp Arg Asp Val Arg Gln Phe Ser Gln Trp Ser 
        35                  40                  45              


Glu Thr Asp Leu Leu His Gly His Pro Leu Phe Leu Arg Arg Lys Pro 
    50                  55                  60                  


Val Leu Ser Phe Gln Gly Ser His Leu Arg Ser Arg Ala Thr Tyr Leu 
65                  70                  75                  80  


Val Phe Leu Pro Gly Leu His Val Gly Leu Cys Ser Gly Pro Cys Glu 
                85                  90                  95      


Met Ala Glu Gln Arg Phe Cys Val Asp Tyr Ala Lys Arg Gly Thr Ala 
            100                 105                 110         


Gly Cys Lys Lys Cys Lys Glu Lys Ile Val Lys Gly Val Cys Arg Ile 
        115                 120                 125             


Gly Lys Val Val Pro Asn Pro Phe Ser Glu Ser Gly Gly Asp Met Lys 
    130                 135                 140                 


Glu Trp Tyr His Ile Lys Cys Met Phe Glu Lys Leu Glu Arg Ala Arg 
145                 150                 155                 160 


Ala Thr Thr Lys Lys Ile Glu Asp Leu Thr Glu Leu Glu Gly Trp Glu 
                165                 170                 175     


Glu Leu Glu Asp Asn Glu Lys Glu Gln Ile Thr Gln His Ile Ala Asp 
            180                 185                 190         


Leu Ser Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln 
        195                 200                 205             


Ala Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala 
    210                 215                 220                 


Ser Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala 
225                 230                 235                 240 


Lys Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg 
                245                 250                 255     


Ser Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu 
            260                 265                 270         


Arg Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr 
        275                 280                 285             


Asn Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala 
    290                 295                 300                 


Gly Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu 
305                 310                 315                 320 


Pro Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val 
                325                 330                 335     


Lys Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg 
            340                 345                 350         


Asp Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu 
        355                 360                 365             


Gln Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln 
    370                 375                 380                 


Glu Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp 
385                 390                 395                 400 


Glu Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn 
                405                 410                 415     


Asp Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn 
            420                 425                 430         


Ser Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu 
        435                 440                 445             


Ala Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu 
    450                 455                 460                 


His Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu 
465                 470                 475                 480 


Ser Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu 
                485                 490                 495     


Ala Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met 
            500                 505                 510         


Phe Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn 
        515                 520                 525             


Gly Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro 
    530                 535                 540                 


His Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly 
545                 550                 555                 560 


Gly His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys 
                565                 570                 575     


Thr Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala 
            580                 585                 590         


Ala Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr 
        595                 600                 605             


Phe Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys 
    610                 615                 620                 


Phe Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser 
625                 630                 635                 640 


Glu Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr 
                645                 650                 655     


Arg Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys 
            660                 665                 670         


Gly Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp 
        675                 680                 685             


Tyr Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu 
    690                 695                 700                 


Gly Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe 
705                 710                 715                 720 


Leu Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr 
                725                 730                 735     


Lys Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn 
            740                 745                 750         


Glu Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser 
        755                 760                 765             


Trp Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp 
    770                 775                 780                 


Pro Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys 
785                 790                 795                 800 


Ser Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys 
                805                 810                 815     


Thr Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro 
            820                 825                 830         


Gln Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr 
        835                 840                 845             


Val Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu 
    850                 855                 860                 


Glu Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser 
865                 870                 875                 880 


Lys Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser 
                885                 890                 895     


Asn Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys 
            900                 905                 910         


Val Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu 
        915                 920                 925             


Lys Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Val Leu Leu 
    930                 935                 940                 


Asp Ile Phe Thr Gly Val Arg Leu Tyr Leu Pro Pro Ser Thr Pro Asp 
945                 950                 955                 960 


Phe Ser Arg Leu Arg Arg Tyr Phe Val Ala Phe Asp Gly Asp Leu Val 
                965                 970                 975     


Gln Glu Phe Asp Met Thr Ser Ala Thr His Val Leu Gly Ser Arg Asp 
            980                 985                 990         


Lys Asn Pro Ala Ala Gln Gln Val  Ser Pro Glu Trp Ile  Trp Ala Cys 
        995                 1000                 1005             


Ile Arg  Lys Arg Arg Leu Val  Ala Pro Cys 
    1010                 1015             


<210>  6204
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIG4__Homo_sapiens__XP_005254115

<400>  6204

Met Ala Ala Ser Gln Thr Ser Gln Thr Val Ala Ser His Val Pro Phe 
1               5                   10                  15      


Ala Asp Leu Cys Ser Thr Leu Glu Arg Ile Gln Lys Ser Lys Gly Arg 
            20                  25                  30          


Ala Glu Lys Ile Arg His Phe Arg Glu Phe Leu Asp Ser Trp Arg Lys 
        35                  40                  45              


Phe His Asp Ala Leu His Lys Asn His Lys Asp Val Thr Asp Ser Phe 
    50                  55                  60                  


Tyr Pro Ala Met Arg Leu Ile Leu Pro Gln Leu Glu Arg Glu Arg Met 
65                  70                  75                  80  


Ala Tyr Gly Ile Lys Glu Thr Met Leu Ala Lys Leu Tyr Ile Glu Leu 
                85                  90                  95      


Leu Asn Leu Pro Arg Asp Gly Lys Asp Ala Leu Lys Leu Leu Asn Tyr 
            100                 105                 110         


Arg Thr Pro Thr Gly Thr His Gly Asp Ala Gly Asp Phe Ala Met Ile 
        115                 120                 125             


Ala Tyr Phe Val Leu Lys Pro Arg Cys Leu Gln Lys Gly Ser Leu Thr 
    130                 135                 140                 


Ile Gln Gln Val Asn Asp Leu Leu Asp Ser Ile Ala Ser Asn Asn Ser 
145                 150                 155                 160 


Ala Lys Arg Lys Asp Leu Ile Lys Lys Ser Leu Leu Gln Leu Ile Thr 
                165                 170                 175     


Gln Ser Ser Ala Leu Glu Gln Lys Trp Leu Ile Arg Met Ile Ile Lys 
            180                 185                 190         


Asp Leu Lys Leu Gly Val Ser Gln Gln Thr Ile Phe Ser Val Phe His 
        195                 200                 205             


Asn Asp Ala Ala Glu Leu His Asn Val Thr Thr Asp Leu Glu Lys Val 
    210                 215                 220                 


Cys Arg Gln Leu His Asp Pro Ser Val Gly Leu Ser Asp Ile Ser Ile 
225                 230                 235                 240 


Thr Leu Phe Ser Ala Phe Lys Pro Met Leu Ala Ala Ile Ala Asp Ile 
                245                 250                 255     


Glu His Ile Glu Lys Asp Met Lys His Gln Ser Phe Tyr Ile Glu Thr 
            260                 265                 270         


Lys Leu Asp Gly Glu Arg Met Gln Met His Lys Asp Gly Asp Val Tyr 
        275                 280                 285             


Lys Tyr Phe Ser Arg Asn Gly Tyr Asn Tyr Thr Asp Gln Phe Gly Ala 
    290                 295                 300                 


Ser Pro Thr Glu Gly Ser Leu Thr Pro Phe Ile His Asn Ala Phe Lys 
305                 310                 315                 320 


Ala Asp Ile Gln Ile Cys Ile Leu Asp Gly Glu Met Met Ala Tyr Asn 
                325                 330                 335     


Pro Asn Thr Gln Thr Phe Met Gln Lys Gly Thr Lys Phe Asp Ile Lys 
            340                 345                 350         


Arg Met Val Glu Asp Ser Asp Leu Gln Thr Cys Tyr Cys Val Phe Asp 
        355                 360                 365             


Val Leu Met Val Asn Asn Lys Lys Leu Gly His Glu Thr Leu Arg Lys 
    370                 375                 380                 


Arg Tyr Glu Ile Leu Ser Ser Ile Phe Thr Pro Ile Pro Gly Arg Ile 
385                 390                 395                 400 


Glu Ile Val Gln Lys Thr Gln Ala His Thr Lys Asn Glu Val Ile Asp 
                405                 410                 415     


Ala Leu Asn Glu Ala Ile Asp Lys Arg Glu Glu Gly Ile Met Val Lys 
            420                 425                 430         


Gln Pro Leu Ser Ile Tyr Lys Pro Asp Lys Arg Gly Glu Gly Trp Leu 
        435                 440                 445             


Lys Ile Lys Pro Glu Tyr Val Ser Gly Leu Met Asp Glu Leu Asp Ile 
    450                 455                 460                 


Leu Ile Val Gly Gly Tyr Trp Gly Lys Gly Ser Arg Gly Gly Met Met 
465                 470                 475                 480 


Ser His Phe Leu Cys Ala Val Ala Glu Lys Pro Pro Pro Gly Glu Lys 
                485                 490                 495     


Pro Ser Val Phe His Thr Leu Ser Arg Val Gly Ser Gly Cys Thr Met 
            500                 505                 510         


Lys Glu Leu Tyr Asp Leu Gly Leu Lys Leu Ala Lys Tyr Trp Lys Pro 
        515                 520                 525             


Phe His Arg Lys Ala Pro Pro Ser Ser Ile Leu Cys Gly Thr Glu Lys 
    530                 535                 540                 


Pro Glu Val Tyr Ile Glu Pro Cys Asn Ser Val Ile Val Gln Ile Lys 
545                 550                 555                 560 


Ala Ala Glu Ile Val Pro Ser Asp Met Tyr Lys Thr Gly Cys Thr Leu 
                565                 570                 575     


Arg Phe Pro Arg Ile Glu Lys Ile Arg Asp Asp Lys Glu Trp His Glu 
            580                 585                 590         


Cys Met Thr Leu Asp Asp Leu Glu Gln Leu Arg Gly Lys Ala Ser Gly 
        595                 600                 605             


Lys Leu Ala Ser Lys His Leu Tyr Ile Gly Gly Asp Asp Glu Pro Gln 
    610                 615                 620                 


Glu Lys Lys Arg Lys Ala Ala Pro Lys Met Lys Lys Val Ile Gly Ile 
625                 630                 635                 640 


Ile Glu His Leu Lys Ala Pro Asn Leu Thr Asn Val Asn Lys Ile Ser 
                645                 650                 655     


Asn Ile Phe Glu Asp Val Glu Phe Cys Val Met Ser Gly Thr Asp Ser 
            660                 665                 670         


Gln Pro Lys Pro Asp Leu Glu Asn Arg Ile Ala Glu Phe Gly Gly Tyr 
        675                 680                 685             


Ile Val Gln Asn Pro Gly Pro Asp Thr Tyr Cys Val Ile Ala Gly Ser 
    690                 695                 700                 


Glu Asn Ile Arg Val Lys Asn Ile Ile Leu Ser Asn Lys His Asp Val 
705                 710                 715                 720 


Val Lys Pro Ala Trp Leu Leu Glu Cys Phe Lys Thr Lys Ser Phe Val 
                725                 730                 735     


Pro Trp Gln Pro Arg Phe Met Ile His Met Cys Pro Ser Thr Lys Glu 
            740                 745                 750         


His Phe Ala Arg Glu Tyr Asp Cys Tyr Gly Asp Ser Tyr Phe Ile Asp 
        755                 760                 765             


Thr Asp Leu Asn Gln Leu Lys Glu Val Phe Ser Gly Ile Lys Asn Ser 
    770                 775                 780                 


Asn Glu Gln Thr Pro Glu Glu Met Ala Ser Leu Ile Ala Asp Leu Glu 
785                 790                 795                 800 


Tyr Arg Tyr Ser Trp Asp Cys Ser Pro Leu Ser Met Phe Arg Arg His 
                805                 810                 815     


Thr Val Tyr Leu Asp Ser Tyr Ala Val Ile Asn Asp Leu Ser Thr Lys 
            820                 825                 830         


Asn Glu Gly Thr Arg Leu Ala Ile Lys Ala Leu Glu Leu Arg Phe His 
        835                 840                 845             


Gly Ala Lys Val Val Ser Cys Leu Ala Glu Gly Val Ser His Val Ile 
    850                 855                 860                 


Ile Gly Glu Asp His Ser Arg Val Ala Asp Phe Lys Ala Phe Arg Arg 
865                 870                 875                 880 


Thr Phe Lys Arg Lys Phe Lys Ile Leu Lys Glu Ser Trp Val Thr Asp 
                885                 890                 895     


Ser Ile Asp Lys Cys Glu Leu Gln Glu Glu Asn Gln Tyr Leu Ile 
            900                 905                 910     


<210>  6205
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRA1__Homo_sapiens__NP_006854

<400>  6205

Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Arg Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Ile Leu Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Ile Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Phe Tyr Gly Ser His Thr Ala Gly Trp Ser Glu Pro Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Leu Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu His 
    130                 135                 140                 


Cys Val Ser Gln Val Ala Phe Gly Ser Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro Arg Thr His Gly 
                165                 170                 175     


Trp Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Ser Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro His Val Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Gly Glu 
225                 230                 235                 240 


Ser Leu Thr Leu Gln Cys Val Ser Asp Val Ser Tyr Asp Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Leu Pro Gly Pro Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Ser Gly Ala Tyr Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Arg Gly Arg Pro Phe Ile Ser Val His Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Gly Pro Phe 
            340                 345                 350         


His Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg 
        355                 360                 365             


Leu Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Ser Pro Val Thr Ser Ala His Ser Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Leu Ser Ser Asn Pro Tyr Leu Leu Ser His Pro Ser Asp Ser Leu Glu 
                405                 410                 415     


Leu Met Val Ser Gly Ala Ala Glu Thr Leu Ser Pro Pro Gln Asn Lys 
            420                 425                 430         


Ser Asp Ser Lys Ala Gly Ala Ala Asn Thr Leu Ser Pro Ser Gln Asn 
        435                 440                 445             


Lys Thr Ala Ser His Pro Gln Asp Tyr Thr Val Glu Asn Leu Ile Arg 
    450                 455                 460                 


Met Gly Ile Ala Gly Leu Val Leu Val Val Leu Gly Ile Leu Leu Phe 
465                 470                 475                 480 


Glu Ala Gln His Ser Gln Arg Ser Leu 
                485                 


<210>  6206
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRA2__Homo_sapiens__NP_006857

<400>  6206

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ile Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Gln Ala Glu Glu Tyr His Leu Tyr Arg Glu Asn 
    50                  55                  60                  


Lys Ser Ala Ser Trp Val Arg Arg Ile Gln Glu Pro Gly Lys Asn Gly 
65                  70                  75                  80  


Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr His 
                85                  90                  95      


Cys Gln Tyr Tyr Ser His Asn His Ser Ser Glu Tyr Ser Asp Pro Leu 
            100                 105                 110         


Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Leu Gln Cys Val 
    130                 135                 140                 


Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp 
145                 150                 155                 160 


Glu His Pro Gln Arg Leu Asn Ser His Ser His Ala Arg Gly Trp Ser 
                165                 170                 175     


Trp Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Ser 
            180                 185                 190         


Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Val Trp Ser Leu 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro 
    210                 215                 220                 


Ser Leu Ser Val Gln Pro Gly Pro Met Val Ala Pro Gly Glu Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Trp Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Ser Ala His Asn Leu Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Phe 
305                 310                 315                 320 


Tyr Asp Arg Pro Ser Leu Ser Val Gln Pro Val Pro Thr Val Ala Pro 
                325                 330                 335     


Gly Lys Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Gln Phe His Thr 
            340                 345                 350         


Phe Leu Leu Thr Lys Glu Gly Ala Gly His Pro Pro Leu His Leu Arg 
        355                 360                 365             


Ser Glu His Gln Ala Gln Gln Asn Gln Ala Glu Phe Arg Met Gly Pro 
    370                 375                 380                 


Val Thr Ser Ala His Val Gly Thr Tyr Arg Cys Tyr Ser Ser Leu Ser 
385                 390                 395                 400 


Ser Asn Pro Tyr Leu Leu Ser Leu Pro Ser Asp Pro Leu Glu Leu Val 
                405                 410                 415     


Val Ser Ala Ser Leu Gly Gln His Pro Gln Asp Tyr Thr Val Glu Asn 
            420                 425                 430         


Leu Ile Arg Met Gly Val Ala Gly Leu Val Leu Val Val Leu Gly Ile 
        435                 440                 445             


Leu Leu Phe Glu Ala Gln His Ser Gln Arg Ser Leu Gln Asp Ala Ala 
    450                 455                 460                 


Gly Arg 
465     


<210>  6207
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRA3__Homo_sapiens__NP_001166125

<400>  6207

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Asp 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Thr Gln Glu Tyr His Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Leu Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Cys Cys Ile Tyr Gly Ser His Thr Ala Gly Leu Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Leu Pro Ser Pro Val Val Thr Ser Gly Gly Asn Val Thr Ile Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Val Ser Lys 
145                 150                 155                 160 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Val Val Ala Pro Gly Glu 
                165                 170                 175     


Lys Leu Thr Phe Gln Cys Gly Ser Asp Ala Gly Tyr Asp Arg Phe Val 
            180                 185                 190         


Leu Tyr Lys Glu Trp Gly Arg Asp Phe Leu Gln Arg Pro Gly Arg Gln 
        195                 200                 205             


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
    210                 215                 220                 


Arg Ser Tyr Gly Gly Gln Tyr Thr Cys Ser Gly Ala Tyr Asn Leu Ser 
225                 230                 235                 240 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly 
                245                 250                 255     


Gln Ile Arg Ala Arg Pro Phe Leu Ser Val Arg Pro Gly Pro Thr Val 
            260                 265                 270         


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Gly Met 
        275                 280                 285             


His Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Ser Pro Leu Arg 
    290                 295                 300                 


Leu Lys Ser Lys Arg Gln Ser His Lys Tyr Gln Ala Glu Phe Pro Met 
305                 310                 315                 320 


Ser Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
                325                 330                 335     


Leu Ser Ser Asn Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
            340                 345                 350         


Leu Val Val Ser Gly Ala Ala Glu Thr Leu Ser Pro Pro Gln Asn Lys 
        355                 360                 365             


Ser Asp Ser Lys Ala Gly Glu 
    370                 375 


<210>  6208
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRA4__Homo_sapiens__NP_036408

<400>  6208

Met Thr Leu Ile Leu Thr Ser Leu Leu Phe Phe Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Ala Glu Asn Leu Leu Lys Pro Ile Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Pro Val Ile Thr Trp His Asn Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Thr Leu Glu Ala Gln Gly Tyr Arg Leu Asp Lys Glu Gly 
    50                  55                  60                  


Asn Ser Met Ser Arg His Ile Leu Lys Thr Leu Glu Ser Glu Asn Lys 
65                  70                  75                  80  


Val Lys Leu Ser Ile Pro Ser Met Met Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


His Cys Tyr Tyr Gln Ser Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Val Thr Ala Tyr Ser Arg Pro Thr Leu Ser Ala Leu 
        115                 120                 125             


Pro Ser Pro Val Val Thr Ser Gly Val Asn Val Thr Leu Arg Cys Ala 
    130                 135                 140                 


Ser Arg Leu Gly Leu Gly Arg Phe Thr Leu Ile Glu Glu Gly Asp His 
145                 150                 155                 160 


Arg Leu Ser Trp Thr Leu Asn Ser His Gln His Asn His Gly Lys Phe 
                165                 170                 175     


Gln Ala Leu Phe Pro Met Gly Pro Leu Thr Phe Ser Asn Arg Gly Thr 
            180                 185                 190         


Phe Arg Cys Tyr Gly Tyr Glu Asn Asn Thr Pro Tyr Val Trp Ser Glu 
        195                 200                 205             


Pro Ser Asp Pro Leu Gln Leu Leu Val Ser Gly Val Ser Arg Lys Pro 
    210                 215                 220                 


Ser Leu Leu Thr Leu Gln Gly Pro Val Val Thr Pro Gly Glu Asn Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Ile Arg Tyr Thr Leu Tyr 
                245                 250                 255     


Lys Glu Gly Ala Asp Gly Leu Pro Gln Arg Pro Gly Arg Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Ser Pro Val Ser Arg Ser 
        275                 280                 285             


Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Val Ser Ser Glu 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Ile 
305                 310                 315                 320 


Ser Asp Arg Pro Ser Leu Ser Val Gln Pro Gly Pro Thr Val Thr Ser 
                325                 330                 335     


Gly Glu Lys Val Thr Leu Leu Cys Gln Ser Trp Asp Pro Met Phe Thr 
            340                 345                 350         


Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu Arg 
        355                 360                 365             


Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro 
    370                 375                 380                 


Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg Ser 
385                 390                 395                 400 


Ser Asn Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val 
                405                 410                 415     


Val Ser Gly Ala Thr Glu Thr Leu Asn Pro Ala Gln Lys Lys Ser Asp 
            420                 425                 430         


Ser Lys Thr Ala Pro His Leu Gln Asp Tyr Thr Val Glu Asn Leu Ile 
        435                 440                 445             


Arg Met Gly Val Ala Gly Leu Val Leu Leu Phe Leu Gly Ile Leu Leu 
    450                 455                 460                 


Phe Glu Ala Gln His Ser Gln Arg Ser Pro Pro Arg Cys Ser Gln Glu 
465                 470                 475                 480 


Ala Asn Ser Arg Lys Asp Asn Ala Pro Phe Arg Val Val Glu Pro Trp 
                485                 490                 495     


Glu Gln Ile 
            


<210>  6209
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRA5__Homo_sapiens__NP_067073

<400>  6209

Met Ala Pro Trp Ser His Pro Ser Ala Gln Leu Gln Pro Val Gly Gly 
1               5                   10                  15      


Asp Ala Val Ser Pro Ala Leu Met Val Leu Leu Cys Leu Gly Leu Ser 
            20                  25                  30          


Leu Gly Pro Arg Thr His Val Gln Ala Gly Asn Leu Ser Lys Ala Thr 
        35                  40                  45              


Leu Trp Ala Glu Pro Gly Ser Val Ile Ser Arg Gly Asn Ser Val Thr 
    50                  55                  60                  


Ile Arg Cys Gln Gly Thr Leu Glu Ala Gln Glu Tyr Arg Leu Val Lys 
65                  70                  75                  80  


Glu Gly Ser Pro Glu Pro Trp Asp Thr Gln Asn Pro Leu Glu Pro Lys 
                85                  90                  95      


Asn Lys Ala Arg Phe Ser Ile Pro Ser Met Thr Glu His His Ala Gly 
            100                 105                 110         


Arg Tyr Arg Cys Tyr Tyr Tyr Ser Pro Ala Gly Trp Ser Glu Pro Ser 
        115                 120                 125             


Asp Pro Leu Glu Leu Val Val Thr Gly Phe Tyr Asn Lys Pro Thr Leu 
    130                 135                 140                 


Ser Ala Leu Pro Ser Pro Val Val Thr Ser Gly Glu Asn Val Thr Leu 
145                 150                 155                 160 


Gln Cys Gly Ser Arg Leu Arg Phe Asp Arg Phe Ile Leu Thr Glu Glu 
                165                 170                 175     


Gly Asp His Lys Leu Ser Trp Thr Leu Asp Ser Gln Leu Thr Pro Ser 
            180                 185                 190         


Gly Gln Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His 
        195                 200                 205             


Arg Trp Met Leu Arg Cys Tyr Gly Ser Arg Arg His Ile Leu Gln Val 
    210                 215                 220                 


Trp Ser Glu Pro Ser Asp Leu Leu Glu Ile Pro Val Ser Gly Ala Ala 
225                 230                 235                 240 


Asp Asn Leu Ser Pro Ser Gln Asn Lys Ser Asp Ser Gly Thr Ala Ser 
                245                 250                 255     


His Leu Gln Asp Tyr Ala Val Glu Asn Leu Ile Arg Met Gly Met Ala 
            260                 265                 270         


Gly Leu Ile Leu Val Val Leu Gly Ile Leu Ile Phe Gln Asp Trp His 
        275                 280                 285             


Ser Gln Arg Ser Pro Gln Ala Ala Ala Gly Arg 
    290                 295                 


<210>  6210
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1__Homo_sapiens__NP_001075107

<400>  6210

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Pro Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Thr Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr 
        435                 440                 445             


Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile 
    450                 455                 460                 


Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu 
465                 470                 475                 480 


Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr 
                485                 490                 495     


Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu 
            500                 505                 510         


Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala 
        515                 520                 525             


Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp 
    530                 535                 540                 


Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala 
545                 550                 555                 560 


Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
                565                 570                 575     


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            580                 585                 590         


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        595                 600                 605             


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    610                 615                 620                 


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala 
625                 630                 635                 640 


Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650     


<210>  6211
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB2__Homo_sapiens__NP_001265333

<400>  6211

Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro 
1               5                   10                  15      


Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val 
            20                  25                  30          


Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro 
        35                  40                  45              


Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile 
    50                  55                  60                  


Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys 
65                  70                  75                  80  


Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp 
                85                  90                  95      


Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser 
            100                 105                 110         


Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser Leu Thr Leu Gln 
        115                 120                 125             


Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly 
    130                 135                 140                 


Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu 
145                 150                 155                 160 


Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly 
                165                 170                 175     


Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala 
            180                 185                 190         


Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr 
        195                 200                 205             


Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn 
    210                 215                 220                 


Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu 
225                 230                 235                 240 


Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His 
                245                 250                 255     


Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser 
            260                 265                 270         


Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro 
        275                 280                 285             


Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly 
    290                 295                 300                 


Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro Ile Ser Thr Pro 
305                 310                 315                 320 


Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln 
                325                 330                 335     


Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala 
            340                 345                 350         


Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg 
        355                 360                 365             


His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp 
    370                 375                 380                 


Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly 
385                 390                 395                 400 


Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu 
                405                 410                 415     


Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly Val Glu Met Asp 
            420                 425                 430         


Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln 
        435                 440                 445             


Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro Pro Pro Ser 
    450                 455                 460                 


Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Thr Leu Ala 
465                 470                 475                 480 


Ile His 
        


<210>  6212
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB3__Homo_sapiens__XP_006726238

<400>  6212

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Leu Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Arg Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro 
        275                 280                 285             


Ser His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asn Ile Leu Met Ala Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Tyr 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Ala Ser His Ala Lys Asp Tyr Thr Val Glu Asn Leu 
        435                 440                 445             


Ile Arg Met Gly Met Ala Gly Leu Val Leu Val Phe Leu Gly Ile Leu 
    450                 455                 460                 


Leu Phe Glu Ala Gln His Ser Gln Arg Asn Pro Gln Asp Ala Ala Gly 
465                 470                 475                 480 


Arg 
    


<210>  6213
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB4__Homo_sapiens__XP_011546956

<400>  6213

Met Glu Gln Pro His Asp Glu Lys Asp Pro Ala Ser Lys Arg Pro His 
1               5                   10                  15      


Pro Val Cys Leu Phe Val Leu Pro Ala Leu Arg Thr His Pro Ser Ala 
            20                  25                  30          


Gln Leu Gly Pro Leu Gly Gly Asp Ala Met Ile Pro Thr Phe Thr Ala 
        35                  40                  45              


Leu Leu Cys Leu Gly Leu Ser Leu Gly Pro Arg Thr His Met Gln Ala 
    50                  55                  60                  


Gly Pro Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
65                  70                  75                  80  


Ser Trp Gly Asn Ser Val Thr Ile Trp Cys Gln Gly Thr Leu Glu Ala 
                85                  90                  95      


Arg Glu Tyr Arg Leu Asp Lys Glu Glu Ser Pro Ala Pro Trp Asp Arg 
            100                 105                 110         


Gln Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile Pro Ser 
        115                 120                 125             


Met Thr Glu Asp Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr Arg Ser Pro 
    130                 135                 140                 


Val Gly Trp Ser Gln Pro Ser Asp Pro Leu Glu Leu Val Met Thr Gly 
145                 150                 155                 160 


Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu Val Thr 
                165                 170                 175     


Ser Gly Lys Ser Val Thr Leu Leu Cys Gln Ser Arg Ser Pro Met Asp 
            180                 185                 190         


Thr Phe Leu Leu Ile Lys Glu Arg Ala Ala His Pro Leu Leu His Leu 
        195                 200                 205             


Arg Ser Glu His Gly Ala Gln Gln His Gln Ala Glu Phe Pro Met Ser 
    210                 215                 220                 


Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Phe Ser Ser His 
225                 230                 235                 240 


Gly Phe Ser His Tyr Leu Leu Ser His Pro Ser Asp Pro Leu Glu Leu 
                245                 250                 255     


Ile Val Ser Gly Ser Leu Glu Asp Pro Arg Pro Ser Pro Thr Arg Ser 
            260                 265                 270         


Val Ser Thr Ala Ala Gly Pro Glu Asp Gln Pro Leu Met Pro Thr Gly 
        275                 280                 285             


Ser Val Pro His Ser Gly Leu Arg Arg His Trp Glu Val Leu Ile Gly 
    290                 295                 300                 


Val Leu Val Val Ser Ile Leu Leu Leu Ser Leu Leu Leu Phe Leu Leu 
305                 310                 315                 320 


Leu Gln His Trp Arg Gln Gly Lys His Arg Thr Leu Ala Gln Arg Gln 
                325                 330                 335     


Ala Asp Phe Gln Arg Pro Pro Gly Ala Ala Glu Pro Glu Pro Lys Asp 
            340                 345                 350         


Gly Gly Leu Gln Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Gly Glu 
        355                 360                 365             


Asn Phe Ser Gly Ala Ala Val Lys Asn Thr Gln Pro Glu Asp Gly Val 
    370                 375                 380                 


Glu Met Asp Thr Arg Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val 
385                 390                 395                 400 


Thr Tyr Ala Lys Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                405                 410                 415     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            420                 425                 430         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        435                 440                 445             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Phe Thr Leu Arg Gln 
    450                 455                 460                 


Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Ala Ser Pro Ala Glu 
465                 470                 475                 480 


Pro Ser Val Tyr Ala Thr Leu Ala Ile His 
                485                 490 


<210>  6214
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB5__Homo_sapiens__NP_001074911

<400>  6214

Met Thr Leu Thr Leu Ser Val Leu Ile Cys Leu Gly Leu Ser Val Gly 
1               5                   10                  15      


Pro Arg Thr Cys Val Gln Ala Gly Thr Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Ala Ser Val Ile Ala Arg Gly Lys Pro Val Thr Leu Trp 
        35                  40                  45              


Cys Gln Gly Pro Leu Glu Thr Glu Glu Tyr Arg Leu Asp Lys Glu Gly 
    50                  55                  60                  


Leu Pro Trp Ala Arg Lys Arg Gln Asn Pro Leu Glu Pro Gly Ala Lys 
65                  70                  75                  80  


Ala Lys Phe His Ile Pro Ser Thr Val Tyr Asp Ser Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Glu Thr Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Ala Thr Gly Phe Tyr Ala Glu Pro Thr Leu Leu Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Val Thr Leu Gln Cys 
    130                 135                 140                 


Asp Thr Leu Asp Gly Leu Leu Thr Phe Val Leu Val Glu Glu Glu Gln 
145                 150                 155                 160 


Lys Leu Pro Arg Thr Leu Tyr Ser Gln Lys Leu Pro Lys Gly Pro Ser 
                165                 170                 175     


Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser Cys Arg Trp Arg 
            180                 185                 190         


Phe Arg Cys Tyr Tyr Tyr Tyr Arg Lys Asn Pro Gln Val Trp Ser Asn 
        195                 200                 205             


Pro Ser Asp Leu Leu Glu Ile Leu Val Pro Gly Val Ser Arg Lys Pro 
    210                 215                 220                 


Ser Leu Leu Ile Pro Gln Gly Ser Val Val Ala Arg Gly Gly Ser Leu 
225                 230                 235                 240 


Thr Leu Gln Cys Arg Ser Asp Val Gly Tyr Asp Ile Phe Val Leu Tyr 
                245                 250                 255     


Lys Glu Gly Glu His Asp Leu Val Gln Gly Ser Gly Gln Gln Pro Gln 
            260                 265                 270         


Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser 
        275                 280                 285             


His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Pro Arg 
    290                 295                 300                 


Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Leu Ile 
305                 310                 315                 320 


Pro Asp Ile Pro Ala Leu Ser Val Gln Pro Gly Pro Lys Val Ala Ser 
                325                 330                 335     


Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp His Gln Ile Asp Thr 
            340                 345                 350         


Phe Phe Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Cys Leu Lys 
        355                 360                 365             


Ser Lys Tyr Gln Ser Tyr Arg His Gln Ala Glu Phe Ser Met Ser Pro 
    370                 375                 380                 


Val Thr Ser Ala Gln Gly Gly Thr Tyr Arg Cys Tyr Ser Ala Ile Arg 
385                 390                 395                 400 


Ser Tyr Pro Tyr Leu Leu Ser Ser Pro Ser Tyr Pro Gln Glu Leu Val 
                405                 410                 415     


Val Ser Gly Pro Ser Gly Asp Pro Ser Leu Ser Pro Thr Gly Ser Thr 
            420                 425                 430         


Pro Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Leu 
        435                 440                 445             


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Thr Gly Val 
    450                 455                 460                 


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
465                 470                 475                 480 


Arg His Arg His Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg 
                485                 490                 495     


Pro Ala Gly Ala Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys 
            500                 505                 510         


Arg Ala Ser Pro Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala 
        515                 520                 525             


Val Lys Asp Thr Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala 
    530                 535                 540                 


Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser 
545                 550                 555                 560 


Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg 
                565                 570                 575     


Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His 
            580                 585                 590     


<210>  6215
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIM2__Homo_sapiens__NP_001155220

<400>  6215

Met Tyr Ser Phe Met Gly Gly Gly Leu Phe Cys Ala Trp Val Gly Thr 
1               5                   10                  15      


Ile Leu Leu Val Val Ala Met Ala Thr Asp His Trp Met Gln Tyr Arg 
            20                  25                  30          


Leu Ser Gly Ser Phe Ala His Gln Gly Leu Trp Arg Tyr Cys Leu Gly 
        35                  40                  45              


Asn Lys Cys Tyr Leu Gln Thr Asp Ser Ile Ala Tyr Trp Asn Ala Thr 
    50                  55                  60                  


Arg Ala Phe Met Ile Leu Ser Ala Leu Cys Ala Ile Ser Gly Ile Ile 
65                  70                  75                  80  


Met Gly Ile Met Ala Phe Ala His Gln Pro Thr Phe Ser Arg Ile Ser 
                85                  90                  95      


Arg Pro Phe Ser Ala Gly Ile Met Phe Phe Ser Ser Thr Leu Phe Val 
            100                 105                 110         


Val Leu Ala Leu Ala Ile Tyr Thr Gly Val Thr Val Ser Phe Leu Gly 
        115                 120                 125             


Arg Arg Phe Gly Asp Trp Arg Phe Ser Trp Ser Tyr Ile Leu Gly Trp 
    130                 135                 140                 


Val Ala Val Leu Met Thr Phe Phe Ala Gly Ile Phe Tyr Met Cys Ala 
145                 150                 155                 160 


Tyr Arg Val His Glu Cys Arg Arg Leu Ser Thr Pro Arg 
                165                 170             


<210>  6216
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMA1__Homo_sapiens__NP_001230704

<400>  6216

Met Glu Gln Lys Glu Asn Val Pro Pro Gly Pro Glu Val Cys Ile Thr 
1               5                   10                  15      


His Gln Glu Gly Glu Lys Ile Ser Ala Asn Glu Asn Ser Leu Ala Val 
            20                  25                  30          


Arg Ser Thr Pro Ala Glu Asp Asp Ser Arg Asp Ser Gln Val Lys Ser 
        35                  40                  45              


Glu Val Gln Gln Pro Val His Pro Lys Pro Leu Ser Pro Asp Ser Arg 
    50                  55                  60                  


Ala Ser Ser Leu Ser Glu Ser Ser Pro Pro Lys Ala Met Lys Lys Phe 
65                  70                  75                  80  


Gln Ala Pro Ala Arg Glu Thr Cys Val Glu Cys Gln Lys Thr Val Tyr 
                85                  90                  95      


Pro Met Glu Arg Leu Leu Ala Asn Gln Gln Val Phe His Ile Ser Cys 
            100                 105                 110         


Phe Arg Cys Ser Tyr Cys Asn Asn Lys Leu Ser Leu Gly Thr Tyr Ala 
        115                 120                 125             


Ser Leu His Gly Arg Ile Tyr Cys Lys Pro His Phe Asn Gln Leu Phe 
    130                 135                 140                 


Lys Ser Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Arg Pro His Lys 
145                 150                 155                 160 


Asp Leu Trp Ala Ser Lys Asn Glu Asn Glu Glu Ile Leu Glu Arg Pro 
                165                 170                 175     


Ala Gln Leu Ala Asn Ala Arg Glu Thr Pro His Ser Pro Gly Val Glu 
            180                 185                 190         


Asp Ala Pro Ile Ala Lys Val Gly Val Leu Ala Ala Ser Met Glu Ala 
        195                 200                 205             


Lys Ala Ser Ser Gln Gln Glu Lys Glu Asp Lys Pro Ala Glu Thr Lys 
    210                 215                 220                 


Lys Leu Arg Ile Ala Trp Pro Pro Pro Thr Glu Leu Gly Ser Ser Gly 
225                 230                 235                 240 


Ser Ala Leu Glu Glu Gly Ile Lys Met Ser Lys Pro Lys Trp Pro Pro 
                245                 250                 255     


Glu Asp Glu Ile Ser Lys Pro Glu Val Pro Glu Asp Val Asp Leu Asp 
            260                 265                 270         


Leu Lys Lys Leu Arg Arg Ser Ser Ser Leu Lys Glu Arg Ser Arg Pro 
        275                 280                 285             


Phe Thr Val Ala Ala Ser Phe Gln Ser Thr Ser Val Lys Ser Pro Lys 
    290                 295                 300                 


Thr Val Ser Pro Pro Ile Arg Lys Gly Trp Ser Met Ser Glu Gln Ser 
305                 310                 315                 320 


Glu Glu Ser Val Gly Gly Arg Val Ala Glu Arg Lys Gln Val Glu Asn 
                325                 330                 335     


Ala Lys Ala Ser Lys Lys Asn Gly Asn Val Gly Lys Thr Thr Trp Gln 
            340                 345                 350         


Asn Lys Glu Ser Lys Gly Glu Thr Gly Lys Arg Ser Lys Glu Gly His 
        355                 360                 365             


Ser Leu Glu Met Glu Asn Glu Asn Leu Val Glu Asn Gly Ala Asp Ser 
    370                 375                 380                 


Asp Glu Asp Asp Asn Ser Phe Leu Lys Gln Gln Ser Pro Gln Glu Pro 
385                 390                 395                 400 


Lys Ser Leu Asn Trp Ser Ser Phe Val Asp Asn Thr Phe Ala Glu Glu 
                405                 410                 415     


Phe Thr Thr Gln Asn Gln Lys Ser Gln Asp Val Glu Leu Trp Glu Gly 
            420                 425                 430         


Glu Val Val Lys Glu Leu Ser Val Glu Glu Gln Ile Lys Arg Asn Arg 
        435                 440                 445             


Tyr Tyr Asp Glu Asp Glu Asp Glu Glu 
    450                 455         


<210>  6217
<211>  1057
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMCH1__Homo_sapiens__NP_001106188

<400>  6217

Met Ala Cys Pro Ala Leu Gly Leu Glu Ala Leu Gln Pro Leu Gln Pro 
1               5                   10                  15      


Glu Pro Pro Pro Glu Pro Ala Phe Ser Glu Ala Gln Lys Trp Ile Glu 
            20                  25                  30          


Gln Val Thr Gly Arg Ser Phe Gly Asp Lys Asp Phe Arg Thr Gly Leu 
        35                  40                  45              


Glu Asn Gly Ile Leu Leu Cys Glu Leu Leu Asn Ala Ile Lys Pro Gly 
    50                  55                  60                  


Leu Val Lys Lys Ile Asn Arg Leu Pro Thr Pro Ile Ala Gly Leu Asp 
65                  70                  75                  80  


Asn Ile Ile Leu Phe Leu Arg Gly Cys Lys Glu Leu Gly Leu Lys Glu 
                85                  90                  95      


Ser Gln Leu Phe Asp Pro Ser Asp Leu Gln Asp Thr Ser Asn Arg Val 
            100                 105                 110         


Thr Val Lys Ser Leu Asp Tyr Ser Arg Lys Leu Lys Asn Val Leu Val 
        115                 120                 125             


Thr Ile Tyr Trp Leu Gly Lys Ala Ala Asn Ser Cys Thr Ser Tyr Ser 
    130                 135                 140                 


Gly Thr Thr Leu Asn Leu Lys Glu Phe Glu Gly Leu Leu Ala Gln Met 
145                 150                 155                 160 


Arg Lys Asp Thr Asp Asp Ile Glu Ser Pro Lys Arg Ser Ile Arg Asp 
                165                 170                 175     


Ser Gly Tyr Ile Asp Cys Trp Asp Ser Glu Arg Ser Asp Ser Leu Ser 
            180                 185                 190         


Pro Pro Arg His Gly Arg Asp Asp Ser Phe Asp Ser Leu Asp Ser Phe 
        195                 200                 205             


Gly Ser Arg Ser Arg Gln Thr Pro Ser Pro Asp Val Val Leu Arg Gly 
    210                 215                 220                 


Ser Ser Asp Gly Arg Gly Ser Asp Ser Glu Ser Asp Leu Pro His Arg 
225                 230                 235                 240 


Lys Leu Pro Asp Val Lys Lys Asp Asp Met Ser Ala Arg Arg Thr Ser 
                245                 250                 255     


His Gly Glu Pro Lys Ser Ala Val Pro Phe Asn Gln Tyr Leu Pro Asn 
            260                 265                 270         


Lys Ser Asn Gln Thr Ala Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys 
        275                 280                 285             


Ala Glu Arg Glu Glu Tyr Arg Lys Ser Trp Ser Thr Ala Thr Ser Pro 
    290                 295                 300                 


Leu Gly Gly Glu Arg Pro Phe Arg Tyr Gly Pro Arg Thr Pro Val Ser 
305                 310                 315                 320 


Asp Asp Ala Glu Ser Thr Ser Met Phe Asp Met Arg Cys Glu Glu Glu 
                325                 330                 335     


Ala Ala Val Gln Pro His Ser Arg Ala Arg Gln Glu Gln Leu Gln Leu 
            340                 345                 350         


Ile Asn Asn Gln Leu Arg Glu Glu Asp Asp Lys Trp Gln Asp Asp Leu 
        355                 360                 365             


Ala Arg Trp Lys Ser Arg Arg Arg Ser Val Ser Gln Asp Leu Ile Lys 
    370                 375                 380                 


Lys Glu Glu Glu Arg Lys Lys Met Glu Lys Leu Leu Ala Gly Glu Asp 
385                 390                 395                 400 


Gly Thr Ser Glu Arg Arg Lys Ser Ile Lys Thr Tyr Arg Glu Ile Val 
                405                 410                 415     


Gln Glu Lys Glu Arg Arg Glu Arg Glu Leu His Glu Ala Tyr Lys Asn 
            420                 425                 430         


Ala Arg Ser Gln Glu Glu Ala Glu Gly Ile Leu Gln Gln Tyr Ile Glu 
        435                 440                 445             


Arg Phe Thr Ile Ser Glu Ala Val Leu Glu Arg Leu Glu Met Pro Lys 
    450                 455                 460                 


Ile Leu Glu Arg Ser His Ser Thr Glu Pro Asn Leu Ser Ser Phe Leu 
465                 470                 475                 480 


Asn Asp Pro Asn Pro Met Lys Tyr Leu Arg Gln Gln Ser Leu Pro Pro 
                485                 490                 495     


Pro Lys Phe Thr Ala Thr Val Glu Thr Thr Ile Ala Arg Ala Ser Val 
            500                 505                 510         


Leu Asp Thr Ser Met Ser Ala Gly Ser Gly Ser Pro Ser Lys Thr Val 
        515                 520                 525             


Thr Pro Lys Ala Val Pro Met Leu Thr Pro Lys Pro Tyr Ser Gln Pro 
    530                 535                 540                 


Lys Asn Ser Gln Asp Val Leu Lys Thr Phe Lys Val Asp Gly Lys Val 
545                 550                 555                 560 


Ser Val Asn Gly Glu Thr Val His Arg Glu Glu Glu Lys Glu Arg Glu 
                565                 570                 575     


Cys Pro Thr Val Ala Pro Ala His Ser Leu Thr Lys Ser Gln Met Phe 
            580                 585                 590         


Glu Gly Val Ala Arg Val His Gly Ser Pro Leu Glu Leu Lys Gln Asp 
        595                 600                 605             


Asn Gly Ser Ile Glu Ile Asn Ile Lys Lys Pro Asn Ser Val Pro Gln 
    610                 615                 620                 


Glu Leu Ala Ala Thr Thr Glu Lys Thr Glu Pro Asn Ser Gln Glu Asp 
625                 630                 635                 640 


Lys Asn Asp Gly Gly Lys Ser Arg Lys Gly Asn Ile Glu Leu Ala Ser 
                645                 650                 655     


Ser Glu Pro Gln His Phe Thr Thr Thr Val Thr Arg Cys Ser Pro Thr 
            660                 665                 670         


Val Ala Phe Val Glu Phe Pro Ser Ser Pro Gln Leu Lys Asn Asp Val 
        675                 680                 685             


Ser Glu Glu Lys Asp Gln Lys Lys Pro Glu Asn Glu Met Ser Gly Lys 
    690                 695                 700                 


Val Glu Leu Val Leu Ser Gln Lys Val Val Lys Pro Lys Ser Pro Glu 
705                 710                 715                 720 


Pro Glu Ala Thr Leu Thr Phe Pro Phe Leu Asp Lys Met Pro Glu Ala 
                725                 730                 735     


Asn Gln Leu His Leu Pro Asn Leu Asn Ser Gln Val Asp Ser Pro Ser 
            740                 745                 750         


Ser Glu Lys Ser Pro Val Met Thr Pro Gln Phe Lys Phe Trp Ala Trp 
        755                 760                 765             


Asp Pro Glu Glu Glu Arg Arg Arg Gln Glu Lys Trp Gln Gln Glu Gln 
    770                 775                 780                 


Glu Arg Leu Leu Gln Glu Arg Tyr Gln Lys Glu Gln Asp Lys Leu Lys 
785                 790                 795                 800 


Glu Glu Trp Glu Lys Ala Gln Lys Glu Val Glu Glu Glu Glu Arg Arg 
                805                 810                 815     


Tyr Tyr Glu Glu Glu Arg Lys Ile Ile Glu Asp Thr Val Val Pro Phe 
            820                 825                 830         


Thr Val Ser Ser Ser Ser Ala Asp Gln Leu Ser Thr Ser Ser Ser Met 
        835                 840                 845             


Thr Glu Gly Ser Gly Thr Met Asn Lys Ile Asp Leu Gly Asn Cys Gln 
    850                 855                 860                 


Asp Glu Lys Gln Asp Arg Arg Trp Lys Lys Ser Phe Gln Gly Asp Asp 
865                 870                 875                 880 


Ser Asp Leu Leu Leu Lys Thr Arg Glu Ser Asp Arg Leu Glu Glu Lys 
                885                 890                 895     


Gly Ser Leu Thr Glu Gly Ala Leu Ala His Ser Gly Asn Pro Val Ser 
            900                 905                 910         


Lys Gly Val His Glu Asp His Gln Leu Asp Thr Glu Ala Gly Ala Pro 
        915                 920                 925             


His Cys Gly Thr Asn Pro Gln Leu Ala Gln Asp Pro Ser Gln Asn Gln 
    930                 935                 940                 


Gln Thr Ser Asn Pro Thr His Ser Ser Glu Asp Val Lys Pro Lys Thr 
945                 950                 955                 960 


Leu Pro Leu Asp Lys Ser Ile Asn His Gln Ile Glu Ser Pro Ser Glu 
                965                 970                 975     


Arg Arg Lys Ser Ile Ser Gly Lys Lys Leu Cys Ser Ser Cys Gly Leu 
            980                 985                 990         


Pro Leu Gly Lys Gly Ala Ala Met  Ile Ile Glu Thr Leu  Asn Leu Tyr 
        995                 1000                 1005             


Phe His  Ile Gln Cys Phe Arg  Cys Gly Ile Cys Lys  Gly Gln Leu 
    1010                 1015                 1020             


Gly Asp  Ala Val Ser Gly Thr  Asp Val Arg Ile Arg  Asn Gly Leu 
    1025                 1030                 1035             


Leu Asn  Cys Asn Asp Cys Tyr  Met Arg Ser Arg Ser  Ala Gly Gln 
    1040                 1045                 1050             


Pro Thr  Thr Leu 
    1055         


<210>  6218
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMD1__Homo_sapiens__NP_055055

<400>  6218

Met Asp Lys Tyr Asp Asp Leu Gly Leu Glu Ala Ser Lys Phe Ile Glu 
1               5                   10                  15      


Asp Leu Asn Met Tyr Glu Ala Ser Lys Asp Gly Leu Phe Arg Val Asp 
            20                  25                  30          


Lys Gly Ala Gly Asn Asn Pro Glu Phe Glu Glu Thr Arg Arg Val Phe 
        35                  40                  45              


Ala Thr Lys Met Ala Lys Ile His Leu Gln Gln Gln Gln Gln Gln Leu 
    50                  55                  60                  


Leu Gln Glu Glu Thr Leu Pro Arg Gly Ser Arg Gly Pro Val Asn Gly 
65                  70                  75                  80  


Gly Gly Arg Leu Gly Pro Gln Ala Arg Trp Glu Val Val Gly Ser Lys 
                85                  90                  95      


Leu Thr Val Asp Gly Ala Ala Lys Pro Pro Leu Ala Ala Ser Thr Gly 
            100                 105                 110         


Ala Pro Gly Ala Val Thr Thr Leu Ala Ala Gly Gln Pro Pro Tyr Pro 
        115                 120                 125             


Pro Gln Glu Gln Arg Ser Arg Pro Tyr Leu His Gly Thr Arg His Gly 
    130                 135                 140                 


Ser Gln Asp Cys Gly Ser Arg Glu Ser Leu Ala Thr Ser Glu Met Ser 
145                 150                 155                 160 


Ala Phe His Gln Pro Gly Pro Cys Glu Asp Pro Ser Cys Leu Thr His 
                165                 170                 175     


Gly Asp Tyr Tyr Asp Asn Leu Ser Leu Ala Ser Pro Lys Trp Gly Asp 
            180                 185                 190         


Lys Pro Gly Val Ser Pro Ser Ile Gly Leu Ser Val Gly Ser Gly Trp 
        195                 200                 205             


Pro Ser Ser Pro Gly Ser Asp Pro Pro Leu Pro Lys Pro Cys Gly Asp 
    210                 215                 220                 


His Pro Leu Asn His Arg Gln Leu Ser Leu Ser Ser Ser Arg Ser Ser 
225                 230                 235                 240 


Glu Gly Ser Leu Gly Gly Gln Asn Ser Gly Ile Gly Gly Arg Ser Ser 
                245                 250                 255     


Glu Lys Pro Thr Gly Leu Trp Ser Thr Ala Ser Ser Gln Arg Val Ser 
            260                 265                 270         


Pro Gly Leu Pro Ser Pro Asn Leu Glu Asn Gly Ala Pro Ala Val Gly 
        275                 280                 285             


Pro Val Gln Pro Arg Thr Pro Ser Val Ser Ala Pro Leu Ala Leu Ser 
    290                 295                 300                 


Cys Pro Arg Gln Gly Gly Leu Pro Arg Ser Asn Ser Gly Leu Gly Gly 
305                 310                 315                 320 


Glu Val Ser Gly Val Met Ser Lys Pro Asn Val Asp Pro Gln Pro Trp 
                325                 330                 335     


Phe Gln Asp Gly Pro Lys Ser Tyr Leu Ser Ser Ser Ala Pro Ser Ser 
            340                 345                 350         


Ser Pro Ala Gly Leu Asp Gly Ser Gln Gln Gly Ala Val Pro Gly Leu 
        355                 360                 365             


Gly Pro Lys Pro Gly Cys Thr Asp Leu Gly Thr Gly Pro Lys Leu Ser 
    370                 375                 380                 


Pro Thr Ser Leu Val His Pro Val Met Ser Thr Leu Pro Glu Leu Ser 
385                 390                 395                 400 


Cys Lys Glu Gly Pro Leu Gly Trp Ser Ser Asp Gly Ser Leu Gly Ser 
                405                 410                 415     


Val Leu Leu Asp Ser Pro Ser Ser Pro Arg Val Arg Leu Pro Cys Gln 
            420                 425                 430         


Pro Leu Val Pro Gly Pro Glu Leu Arg Pro Ser Ala Ala Glu Leu Lys 
        435                 440                 445             


Leu Glu Ala Leu Thr Gln Arg Leu Glu Arg Glu Met Asp Ala His Pro 
    450                 455                 460                 


Lys Ala Asp Tyr Phe Gly Ala Cys Val Lys Cys Ser Lys Gly Val Phe 
465                 470                 475                 480 


Gly Ala Gly Gln Ala Cys Gln Ala Met Gly Asn Leu Tyr His Asp Thr 
                485                 490                 495     


Cys Phe Thr Cys Ala Ala Cys Ser Arg Lys Leu Arg Gly Lys Ala Phe 
            500                 505                 510         


Tyr Phe Val Asn Gly Lys Val Phe Cys Glu Glu Asp Phe Leu Tyr Ser 
        515                 520                 525             


Gly Phe Gln Gln Ser Ala Asp Arg Cys Phe Leu Cys Gly His Leu Ile 
    530                 535                 540                 


Met Asp Met Ile Leu Gln Ala Leu Gly Lys Ser Tyr His Pro Gly Cys 
545                 550                 555                 560 


Phe Arg Cys Val Ile Cys Asn Glu Cys Leu Asp Gly Val Pro Phe Thr 
                565                 570                 575     


Val Asp Ser Glu Asn Lys Ile Tyr Cys Val Arg Asp Tyr His Lys Val 
            580                 585                 590         


Leu Ala Pro Lys Cys Ala Ala Cys Gly Leu Pro Ile Leu Pro Pro Glu 
        595                 600                 605             


Gly Ser Asp Glu Thr Ile Arg Val Val Ser Met Asp Arg Asp Tyr His 
    610                 615                 620                 


Val Glu Cys Tyr His Cys Glu Asp Cys Gly Leu Glu Leu Asn Asp Glu 
625                 630                 635                 640 


Asp Gly His Arg Cys Tyr Pro Leu Glu Asp His Leu Phe Cys His Ser 
                645                 650                 655     


Cys His Val Lys Arg Leu Glu Lys Arg Pro Ser Ser Thr Ala Leu His 
            660                 665                 670         


Gln His His Phe 
        675     


<210>  6219
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMD2__Homo_sapiens__NP_085053

<400>  6219

Met Phe Gln Ala Ala Gly Ala Ala Gln Ala Thr Pro Ser His Asp Ala 
1               5                   10                  15      


Lys Gly Gly Gly Ser Ser Thr Val Gln Arg Ser Lys Ser Phe Ser Leu 
            20                  25                  30          


Arg Ala Gln Val Lys Glu Thr Cys Ala Ala Cys Gln Lys Thr Val Tyr 
        35                  40                  45              


Pro Met Glu Arg Leu Val Ala Asp Lys Leu Ile Phe His Asn Ser Cys 
    50                  55                  60                  


Phe Cys Cys Lys His Cys His Thr Lys Leu Ser Leu Gly Ser Tyr Ala 
65                  70                  75                  80  


Ala Leu His Gly Glu Phe Tyr Cys Lys Pro His Phe Gln Gln Leu Phe 
                85                  90                  95      


Lys Ser Lys Gly Asn Tyr Asp Glu Gly Phe Gly Arg Lys Gln His Lys 
            100                 105                 110         


Glu Leu Trp Ala His Lys Glu Val Asp Pro Gly Thr Lys Thr Ala 
        115                 120                 125         


<210>  6220
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMK1__Homo_sapiens__NP_001191355

<400>  6220

Met Leu Leu Ala Ser Ala Pro Arg Arg Arg Arg Phe Leu Gln Arg Ala 
1               5                   10                  15      


Lys Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr Glu Lys 
            20                  25                  30          


Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr Gly Glu 
        35                  40                  45              


Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val Met Val 
    50                  55                  60                  


Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu Thr Cys 
65                  70                  75                  80  


Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu His Ser 
                85                  90                  95      


Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr Pro Val 
            100                 105                 110         


Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro His Thr 
        115                 120                 125             


Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg Gly Leu 
    130                 135                 140                 


Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly Thr Glu 
145                 150                 155                 160 


His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys Met Ser 
                165                 170                 175     


Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu Glu Ile 
            180                 185                 190         


Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp Leu Leu 
        195                 200                 205             


Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His Asp Pro 
    210                 215                 220                 


His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro Leu Ser 
225                 230                 235                 240 


Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala Arg Gln 
                245                 250                 255     


Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly Ala Gly 
            260                 265                 270         


Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg Ser Glu 
        275                 280                 285             


Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro Ser Asp 
    290                 295                 300                 


Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln Ala Ile 
305                 310                 315                 320 


Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys Glu Leu 
                325                 330                 335     


Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu Val Lys 
            340                 345                 350         


Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile Gly Val 
        355                 360                 365             


Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile Lys Gly 
    370                 375                 380                 


Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr Pro Trp 
385                 390                 395                 400 


Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met Ala Tyr 
                405                 410                 415     


Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His Asn Cys 
            420                 425                 430         


Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly Leu Ala 
        435                 440                 445             


Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg Ser Leu 
    450                 455                 460                 


Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr 
465                 470                 475                 480 


Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu Lys Val 
                485                 490                 495     


Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly Arg Val 
            500                 505                 510         


Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly Leu Asn 
        515                 520                 525             


Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro Pro Ser 
    530                 535                 540                 


Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu Lys Arg 
545                 550                 555                 560 


Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg Met His 
                565                 570                 575     


Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu Asp Arg 
            580                 585                 590         


Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro Ala His 
        595                 600                 605             


Pro Glu Val Pro Asp 
    610             


<210>  6221
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMK2__Homo_sapiens__NP_001026971

<400>  6221

Met Gly Ser Tyr Leu Ser Val Pro Ala Tyr Phe Thr Ser Arg Asp Leu 
1               5                   10                  15      


Phe Arg Cys Ser Glu Cys Gln Asp Ser Leu Thr Asn Trp Tyr Tyr Glu 
            20                  25                  30          


Lys Asp Gly Lys Leu Tyr Cys Pro Lys Asp Tyr Trp Gly Lys Phe Gly 
        35                  40                  45              


Glu Phe Cys His Gly Cys Ser Leu Leu Met Thr Gly Pro Phe Met Val 
    50                  55                  60                  


Ala Gly Glu Phe Lys Tyr His Pro Glu Cys Phe Ala Cys Met Ser Cys 
65                  70                  75                  80  


Lys Val Ile Ile Glu Asp Gly Asp Ala Tyr Ala Leu Val Gln His Ala 
                85                  90                  95      


Thr Leu Tyr Cys Gly Lys Cys His Asn Glu Val Val Leu Ala Pro Met 
            100                 105                 110         


Phe Glu Arg Leu Ser Thr Glu Ser Val Gln Glu Gln Leu Pro Tyr Ser 
        115                 120                 125             


Val Thr Leu Ile Ser Met Pro Ala Thr Thr Glu Gly Arg Arg Gly Phe 
    130                 135                 140                 


Ser Val Ser Val Glu Ser Ala Cys Ser Asn Tyr Ala Thr Thr Val Gln 
145                 150                 155                 160 


Val Lys Glu Val Asn Arg Met His Ile Ser Pro Asn Asn Arg Asn Ala 
                165                 170                 175     


Ile His Pro Gly Asp Arg Ile Leu Glu Ile Asn Gly Thr Pro Val Arg 
            180                 185                 190         


Thr Leu Arg Val Glu Glu Val Glu Asp Ala Ile Ser Gln Thr Ser Gln 
        195                 200                 205             


Thr Leu Gln Leu Leu Ile Glu His Asp Pro Val Ser Gln Arg Leu Asp 
    210                 215                 220                 


Gln Leu Arg Leu Glu Ala Arg Leu Ala Pro His Met Gln Asn Ala Gly 
225                 230                 235                 240 


His Pro His Ala Leu Ser Thr Leu Asp Thr Lys Glu Asn Leu Glu Gly 
                245                 250                 255     


Thr Leu Arg Arg Arg Ser Leu Arg Arg Ser Asn Ser Ile Ser Lys Ser 
            260                 265                 270         


Pro Gly Pro Ser Ser Pro Lys Glu Pro Leu Leu Phe Ser Arg Asp Ile 
        275                 280                 285             


Ser Arg Ser Glu Ser Leu Arg Cys Ser Ser Ser Tyr Ser Gln Gln Ile 
    290                 295                 300                 


Phe Arg Pro Cys Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Phe 
305                 310                 315                 320 


Phe Gly Gln Ala Ile Lys Val Thr His Lys Ala Thr Gly Lys Val Met 
                325                 330                 335     


Val Met Lys Glu Leu Ile Arg Cys Asp Glu Glu Thr Gln Lys Thr Phe 
            340                 345                 350         


Leu Thr Glu Val Lys Val Met Arg Ser Leu Asp His Pro Asn Val Leu 
        355                 360                 365             


Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Lys Leu Asn Leu Leu Thr 
    370                 375                 380                 


Glu Tyr Ile Glu Gly Gly Thr Leu Lys Asp Phe Leu Arg Ser Met Asp 
385                 390                 395                 400 


Pro Phe Pro Trp Gln Gln Lys Val Arg Phe Ala Lys Gly Ile Ala Ser 
                405                 410                 415     


Gly Met Ala Tyr Leu His Ser Met Cys Ile Ile His Arg Asp Leu Asn 
            420                 425                 430         


Ser His Asn Cys Leu Ile Lys Leu Asp Lys Thr Val Val Val Ala Asp 
        435                 440                 445             


Phe Gly Leu Ser Arg Leu Ile Val Glu Glu Arg Lys Arg Ala Pro Met 
    450                 455                 460                 


Glu Lys Ala Thr Thr Lys Lys Arg Thr Leu Arg Lys Asn Asp Arg Lys 
465                 470                 475                 480 


Lys Arg Tyr Thr Val Val Gly Asn Pro Tyr Trp Met Ala Pro Glu Met 
                485                 490                 495     


Leu Asn Gly Lys Ser Tyr Asp Glu Thr Val Asp Ile Phe Ser Phe Gly 
            500                 505                 510         


Ile Val Leu Cys Glu Ile Ile Gly Gln Val Tyr Ala Asp Pro Asp Cys 
        515                 520                 525             


Leu Pro Arg Thr Leu Asp Phe Gly Leu Asn Val Lys Leu Phe Trp Glu 
    530                 535                 540                 


Lys Phe Val Pro Thr Asp Cys Pro Pro Ala Phe Phe Pro Leu Ala Ala 
545                 550                 555                 560 


Ile Cys Cys Arg Leu Glu Pro Glu Ser Arg Ala Pro Pro Gly Ala Ala 
                565                 570                 575     


Gly Glu Gly Pro Gly Cys Ala Asp Asp Glu Gly Pro Val Arg Arg Gln 
            580                 585                 590         


Gly Lys Val Thr Ile Lys Tyr Asp Pro Lys Glu Leu Arg Lys His Leu 
        595                 600                 605             


Asn Leu Glu Glu Trp Ile Leu Glu Gln Leu Thr Arg Leu Tyr Asp Cys 
    610                 615                 620                 


Gln Glu Glu Glu Ile Ser Glu Leu Glu Ile Asp Val Asp Glu Leu Leu 
625                 630                 635                 640 


Asp Met Glu Ser Asp Asp Ala Trp Ala Ser Arg Val Lys Glu Leu Leu 
                645                 650                 655     


Val Asp Cys Tyr Lys Pro Thr Glu Ala Phe Ile Ser Gly Leu Leu Asp 
            660                 665                 670         


Lys Ile Arg Ala Met Gln Lys Leu Ser Thr Pro Gln Lys Lys 
        675                 680                 685     


<210>  6222
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMS1__Homo_sapiens__NP_001180411

<400>  6222

Met Thr Cys Asn Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg 
1               5                   10                  15      


Cys Lys Gly Gly Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly 
            20                  25                  30          


Glu Leu Tyr His Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln 
        35                  40                  45              


Phe Pro Glu Gly Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu 
    50                  55                  60                  


His Asp Phe Gln Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu 
65                  70                  75                  80  


Phe Ile Ile Gly Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro 
                85                  90                  95      


Glu Cys Phe Arg Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly 
            100                 105                 110         


Phe Val Lys Asn Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg 
        115                 120                 125             


Glu Lys Ala Arg Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala 
    130                 135                 140                 


Ile Ile Asp Glu Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro 
145                 150                 155                 160 


Asp His Phe Asn Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala 
                165                 170                 175     


Arg Glu Leu Lys Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met 
            180                 185                 190         


Gly Val Pro Ile Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val 
        195                 200                 205             


Val Asn Ala Met Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala 
    210                 215                 220                 


Lys Cys Glu Lys Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly 
225                 230                 235                 240 


Leu Ala Tyr Cys Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys 
                245                 250                 255     


Phe His Cys Asn Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn 
            260                 265                 270         


Lys Ala Trp Cys Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys 
        275                 280                 285             


Leu Thr Leu Lys Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys 
    290                 295                 300                 


Lys Lys Cys Tyr Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys 
305                 310                 315                 320 


Lys Leu Ala Glu Thr Leu Gly Arg Lys 
                325                 


<210>  6223
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIMS2__Homo_sapiens__NP_001129509

<400>  6223

Met Thr Gly Arg Lys Arg Lys Trp Gly Glu Thr Gly Thr Gly Ser Gly 
1               5                   10                  15      


Ala Ala Pro Ala Ala Ala Leu Arg Trp Ser Asn Met Ser Asp Ala Leu 
            20                  25                  30          


Ala Asn Ala Val Cys Gln Arg Cys Gln Ala Arg Phe Ser Pro Ala Glu 
        35                  40                  45              


Arg Ile Val Asn Ser Asn Gly Glu Leu Tyr His Glu His Cys Phe Val 
    50                  55                  60                  


Cys Ala Gln Cys Phe Arg Pro Phe Pro Glu Gly Leu Phe Tyr Glu Phe 
65                  70                  75                  80  


Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln Met Leu Phe Ala Pro 
                85                  90                  95      


Cys Cys Gly Ser Cys Gly Glu Phe Ile Ile Gly Arg Val Ile Lys Ala 
            100                 105                 110         


Met Asn Asn Asn Trp His Pro Gly Cys Phe Arg Cys Glu Leu Cys Asp 
        115                 120                 125             


Val Glu Leu Ala Asp Leu Gly Phe Val Lys Asn Ala Gly Arg His Leu 
    130                 135                 140                 


Cys Arg Pro Cys His Asn Arg Glu Lys Ala Lys Gly Leu Gly Lys Tyr 
145                 150                 155                 160 


Ile Cys Gln Arg Cys His Leu Val Ile Asp Glu Gln Pro Leu Met Phe 
                165                 170                 175     


Arg Ser Asp Ala Tyr His Pro Asp His Phe Asn Cys Thr His Cys Gly 
            180                 185                 190         


Lys Glu Leu Thr Ala Glu Ala Arg Glu Leu Lys Gly Glu Leu Tyr Cys 
        195                 200                 205             


Leu Pro Cys His Asp Lys Met Gly Val Pro Ile Cys Gly Ala Cys Arg 
    210                 215                 220                 


Arg Pro Ile Glu Gly Arg Val Val Asn Ala Leu Gly Lys Gln Trp His 
225                 230                 235                 240 


Val Glu His Phe Val Cys Ala Lys Cys Glu Lys Pro Phe Leu Gly His 
                245                 250                 255     


Arg His Tyr Glu Lys Lys Gly Leu Ala Tyr Cys Glu Thr His Tyr Asn 
            260                 265                 270         


Gln Leu Phe Gly Asp Val Cys Tyr Asn Cys Ser His Val Ile Glu Gly 
        275                 280                 285             


Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys Val Ser Cys Phe Ser 
    290                 295                 300                 


Cys Ser Thr Cys Asn Ser Lys Leu Thr Leu Lys Asn Lys Phe Val Glu 
305                 310                 315                 320 


Phe Asp Met Lys Pro Val Cys Lys Arg Cys Tyr Glu Lys Phe Pro Leu 
                325                 330                 335     


Glu Leu Lys Lys Arg Leu Lys Lys Leu Ser Glu Leu Thr Ser Arg Lys 
            340                 345                 350         


Ala Gln Pro Lys Ala Thr Asp Leu Asn Ser Ala 
        355                 360             


<210>  6224
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIN28B__Homo_sapiens__NP_001004317

<400>  6224

Met Ala Glu Gly Gly Ala Ser Lys Gly Gly Gly Glu Glu Pro Gly Lys 
1               5                   10                  15      


Leu Pro Glu Pro Ala Glu Glu Glu Ser Gln Val Leu Arg Gly Thr Gly 
            20                  25                  30          


His Cys Lys Trp Phe Asn Val Arg Met Gly Phe Gly Phe Ile Ser Met 
        35                  40                  45              


Ile Asn Arg Glu Gly Ser Pro Leu Asp Ile Pro Val Asp Val Phe Val 
    50                  55                  60                  


His Gln Ser Lys Leu Phe Met Glu Gly Phe Arg Ser Leu Lys Glu Gly 
65                  70                  75                  80  


Glu Pro Val Glu Phe Thr Phe Lys Lys Ser Ser Lys Gly Leu Glu Ser 
                85                  90                  95      


Ile Arg Val Thr Gly Pro Gly Gly Ser Pro Cys Leu Gly Ser Glu Arg 
            100                 105                 110         


Arg Pro Lys Gly Lys Thr Leu Gln Lys Arg Lys Pro Lys Gly Asp Arg 
        115                 120                 125             


Cys Tyr Asn Cys Gly Gly Leu Asp His His Ala Lys Glu Cys Ser Leu 
    130                 135                 140                 


Pro Pro Gln Pro Lys Lys Cys His Tyr Cys Gln Ser Ile Met His Met 
145                 150                 155                 160 


Val Ala Asn Cys Pro His Lys Asn Val Ala Gln Pro Pro Ala Ser Ser 
                165                 170                 175     


Gln Gly Arg Gln Glu Ala Glu Ser Gln Pro Cys Thr Ser Thr Leu Pro 
            180                 185                 190         


Arg Glu Val Gly Gly Gly His Gly Cys Thr Ser Pro Pro Phe Pro Gln 
        195                 200                 205             


Glu Ala Arg Ala Glu Ile Ser Glu Arg Ser Gly Arg Ser Pro Gln Glu 
    210                 215                 220                 


Ala Ser Ser Thr Lys Ser Ser Ile Ala Pro Glu Glu Gln Ser Lys Lys 
225                 230                 235                 240 


Gly Pro Ser Val Gln Lys Arg Lys Lys Thr 
                245                 250 


<210>  6225
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIN52__Homo_sapiens__NP_001019845

<400>  6225

Met Gly Trp Lys Met Ala Ser Pro Thr Asp Gly Thr Asp Leu Glu Ala 
1               5                   10                  15      


Ser Leu Leu Ser Phe Glu Lys Leu Asp Arg Ala Ser Pro Asp Leu Trp 
            20                  25                  30          


Pro Glu Gln Leu Pro Gly Val Ala Glu Phe Ala Ala Ser Phe Lys Ser 
        35                  40                  45              


Pro Ile Thr Ser Ser Pro Pro Lys Trp Met Ala Glu Ile Glu Arg Asp 
    50                  55                  60                  


Asp Ile Asp Met Leu Lys Glu Leu Gly Ser Leu Thr Thr Ala Asn Leu 
65                  70                  75                  80  


Met Glu Lys Val Arg Gly Leu Gln Asn Leu Ala Tyr Gln Leu Gly Leu 
                85                  90                  95      


Asp Glu Ser Arg Glu Met Thr Arg Gly Lys Phe Leu Asn Ile Leu Glu 
            100                 105                 110         


Lys Pro Lys Lys 
        115     


<210>  6226
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIN7A__Homo_sapiens__NP_004655

<400>  6226

Met Leu Lys Pro Ser Val Thr Ser Ala Pro Thr Ala Asp Met Ala Thr 
1               5                   10                  15      


Leu Thr Val Val Gln Pro Leu Thr Leu Asp Arg Asp Val Ala Arg Ala 
            20                  25                  30          


Ile Glu Leu Leu Glu Lys Leu Gln Glu Ser Gly Glu Val Pro Val His 
        35                  40                  45              


Lys Leu Gln Ser Leu Lys Lys Val Leu Gln Ser Glu Phe Cys Thr Ala 
    50                  55                  60                  


Ile Arg Glu Val Tyr Gln Tyr Met His Glu Thr Ile Thr Val Asn Gly 
65                  70                  75                  80  


Cys Pro Glu Phe Arg Ala Arg Ala Thr Ala Lys Ala Thr Val Ala Ala 
                85                  90                  95      


Phe Ala Ala Ser Glu Gly His Ser His Pro Arg Val Val Glu Leu Pro 
            100                 105                 110         


Lys Thr Asp Glu Gly Leu Gly Phe Asn Val Met Gly Gly Lys Glu Gln 
        115                 120                 125             


Asn Ser Pro Ile Tyr Ile Ser Arg Ile Ile Pro Gly Gly Val Ala Glu 
    130                 135                 140                 


Arg His Gly Gly Leu Lys Arg Gly Asp Gln Leu Leu Ser Val Asn Gly 
145                 150                 155                 160 


Val Ser Val Glu Gly Glu His His Glu Lys Ala Val Glu Leu Leu Lys 
                165                 170                 175     


Ala Ala Lys Asp Ser Val Lys Leu Val Val Arg Tyr Thr Pro Lys Val 
            180                 185                 190         


Leu Glu Glu Met Glu Ala Arg Phe Glu Lys Leu Arg Thr Ala Arg Arg 
        195                 200                 205             


Arg Gln Gln Gln Gln Leu Leu Ile Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Thr Gln Gln Asn His Met Ser 
225                 230             


<210>  6227
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIN7B__Homo_sapiens__NP_071448

<400>  6227

Met Ala Ala Leu Val Glu Pro Leu Gly Leu Glu Arg Asp Val Ser Arg 
1               5                   10                  15      


Ala Val Glu Leu Leu Glu Arg Leu Gln Arg Ser Gly Glu Leu Pro Pro 
            20                  25                  30          


Gln Lys Leu Gln Ala Leu Gln Arg Val Leu Gln Ser Arg Phe Cys Ser 
        35                  40                  45              


Ala Ile Arg Glu Val Tyr Glu Gln Leu Tyr Asp Thr Leu Asp Ile Thr 
    50                  55                  60                  


Gly Ser Ala Glu Ile Arg Ala His Ala Thr Ala Lys Ala Thr Val Ala 
65                  70                  75                  80  


Ala Phe Thr Ala Ser Glu Gly His Ala His Pro Arg Val Val Glu Leu 
                85                  90                  95      


Pro Lys Thr Asp Glu Gly Leu Gly Phe Asn Ile Met Gly Gly Lys Glu 
            100                 105                 110         


Gln Asn Ser Pro Ile Tyr Ile Ser Arg Val Ile Pro Gly Gly Val Ala 
        115                 120                 125             


Asp Arg His Gly Gly Leu Lys Arg Gly Asp Gln Leu Leu Ser Val Asn 
    130                 135                 140                 


Gly Val Ser Val Glu Gly Glu Gln His Glu Lys Ala Val Glu Leu Leu 
145                 150                 155                 160 


Lys Ala Ala Gln Gly Ser Val Lys Leu Val Val Arg Tyr Thr Pro Arg 
                165                 170                 175     


Val Leu Glu Glu Met Glu Ala Arg Phe Glu Lys Met Arg Ser Ala Arg 
            180                 185                 190         


Arg Arg Gln Gln His Gln Ser Tyr Ser Ser Leu Glu Ser Arg Gly 
        195                 200                 205         


<210>  6228
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIN7C__Homo_sapiens__NP_060832

<400>  6228

Met Ala Ala Leu Gly Glu Pro Val Arg Leu Glu Arg Asp Ile Cys Arg 
1               5                   10                  15      


Ala Ile Glu Leu Leu Glu Lys Leu Gln Arg Ser Gly Glu Val Pro Pro 
            20                  25                  30          


Gln Lys Leu Gln Ala Leu Gln Arg Val Leu Gln Ser Glu Phe Cys Asn 
        35                  40                  45              


Ala Val Arg Glu Val Tyr Glu His Val Tyr Glu Thr Val Asp Ile Ser 
    50                  55                  60                  


Ser Ser Pro Glu Val Arg Ala Asn Ala Thr Ala Lys Ala Thr Val Ala 
65                  70                  75                  80  


Ala Phe Ala Ala Ser Glu Gly His Ser His Pro Arg Val Val Glu Leu 
                85                  90                  95      


Pro Lys Thr Glu Glu Gly Leu Gly Phe Asn Ile Met Gly Gly Lys Glu 
            100                 105                 110         


Gln Asn Ser Pro Ile Tyr Ile Ser Arg Ile Ile Pro Gly Gly Ile Ala 
        115                 120                 125             


Asp Arg His Gly Gly Leu Lys Arg Gly Asp Gln Leu Leu Ser Val Asn 
    130                 135                 140                 


Gly Val Ser Val Glu Gly Glu His His Glu Lys Ala Val Glu Leu Leu 
145                 150                 155                 160 


Lys Ala Ala Gln Gly Lys Val Lys Leu Val Val Arg Tyr Thr Pro Lys 
                165                 170                 175     


Val Leu Glu Glu Met Glu Ser Arg Phe Glu Lys Met Arg Ser Ala Lys 
            180                 185                 190         


Arg Arg Gln Gln Thr 
        195         


<210>  6229
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIN9__Homo_sapiens__NP_001257338

<400>  6229

Met His Arg Gly Gly Gln Pro Leu Lys Lys Arg Arg Gly Ser Phe Lys 
1               5                   10                  15      


Met Ala Glu Leu Asp Gln Leu Pro Asp Glu Ser Ser Ser Ala Lys Ala 
            20                  25                  30          


Leu Val Ser Leu Lys Glu Gly Ser Leu Ser Asn Thr Trp Asn Glu Lys 
        35                  40                  45              


Tyr Ser Ser Leu Gln Lys Thr Pro Val Trp Lys Gly Arg Asn Thr Ser 
    50                  55                  60                  


Ser Ala Val Glu Met Lys Phe Thr Ala Thr Met Ser Thr Pro Asp Lys 
65                  70                  75                  80  


Lys Ala Ser Gln Lys Ile Gly Phe Arg Leu Arg Asn Leu Leu Lys Leu 
                85                  90                  95      


Pro Lys Ala His Lys Trp Cys Ile Tyr Glu Trp Phe Tyr Ser Asn Ile 
            100                 105                 110         


Asp Lys Pro Leu Phe Glu Gly Asp Asn Asp Phe Cys Val Cys Leu Lys 
        115                 120                 125             


Glu Ser Phe Pro Asn Leu Lys Thr Arg Lys Leu Thr Arg Val Glu Trp 
    130                 135                 140                 


Gly Lys Ile Arg Arg Leu Met Gly Lys Pro Arg Arg Cys Ser Ser Ala 
145                 150                 155                 160 


Phe Phe Glu Glu Glu Arg Ser Ala Leu Lys Gln Lys Arg Gln Lys Ile 
                165                 170                 175     


Arg Leu Leu Gln Gln Arg Lys Val Ala Asp Val Ser Gln Phe Lys Asp 
            180                 185                 190         


Leu Pro Asp Glu Ile Pro Leu Pro Leu Val Ile Gly Thr Lys Val Thr 
        195                 200                 205             


Ala Arg Leu Arg Gly Val His Asp Gly Leu Phe Thr Gly Gln Ile Asp 
    210                 215                 220                 


Ala Val Asp Thr Leu Asn Ala Thr Tyr Arg Val Thr Phe Asp Arg Thr 
225                 230                 235                 240 


Gly Leu Gly Thr His Thr Ile Pro Asp Tyr Glu Val Leu Ser Asn Glu 
                245                 250                 255     


Pro His Glu Thr Met Pro Ile Ala Ala Phe Gly Gln Lys Gln Arg Pro 
            260                 265                 270         


Ser Arg Phe Phe Met Thr Pro Pro Arg Leu His Tyr Thr Pro Pro Leu 
        275                 280                 285             


Gln Ser Pro Ile Ile Asp Asn Asp Pro Leu Leu Gly Gln Ser Pro Trp 
    290                 295                 300                 


Arg Ser Lys Ile Ser Gly Ser Asp Thr Glu Thr Leu Gly Gly Phe Pro 
305                 310                 315                 320 


Val Glu Phe Leu Ile Gln Val Thr Arg Leu Ser Lys Ile Leu Met Ile 
                325                 330                 335     


Lys Lys Glu His Ile Lys Lys Leu Arg Glu Met Asn Thr Glu Ala Glu 
            340                 345                 350         


Lys Leu Lys Ser Tyr Ser Met Pro Ile Ser Ile Glu Phe Gln Arg Arg 
        355                 360                 365             


Tyr Ala Thr Ile Val Leu Glu Leu Glu Gln Leu Asn Lys Asp Leu Asn 
    370                 375                 380                 


Lys Val Leu His Lys Val Gln Gln Tyr Cys Tyr Glu Leu Ala Pro Asp 
385                 390                 395                 400 


Gln Gly Leu Gln Pro Ala Asp Gln Pro Thr Asp Met Arg Arg Arg Cys 
                405                 410                 415     


Glu Glu Glu Ala Gln Glu Ile Val Arg His Ala Asn Ser Ser Thr Gly 
            420                 425                 430         


Gln Pro Cys Val Glu Asn Glu Asn Leu Thr Asp Leu Ile Ser Arg Leu 
        435                 440                 445             


Thr Ala Ile Leu Leu Gln Ile Lys Cys Leu Ala Glu Gly Gly Asp Leu 
    450                 455                 460                 


Asn Ser Phe Glu Phe Lys Ser Leu Thr Asp Ser Leu Asn Asp Ile Lys 
465                 470                 475                 480 


Ser Thr Ile Asp Ala Ser Asn Ile Ser Cys Phe Gln Asn Asn Val Glu 
                485                 490                 495     


Ile His Val Ala His Ile Gln Ser Gly Leu Ser Gln Met Gly Asn Leu 
            500                 505                 510         


His Ala Phe Ala Ala Asn Asn Thr Asn Arg Asp 
        515                 520             


<210>  6230
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LINGO1__Homo_sapiens__NP_001288126

<400>  6230

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  6231
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LINGO2__Homo_sapiens__XP_011516032

<400>  6231

Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15      


Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30          


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45              


Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60                  


Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80  


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95      


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110         


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125             


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140                 


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160 


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175     


Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190         


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His Leu 
        195                 200                 205             


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220                 


Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met 
225                 230                 235                 240 


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Val 
                245                 250                 255     


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270         


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285             


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile 
    290                 295                 300                 


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320 


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335     


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350         


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu Gln 
        355                 360                 365             


Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380                 


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400 


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415     


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430         


Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445             


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460                 


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480 


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495     


Ser Leu Thr Val Lys Gly Phe Ala Ser Asp Arg Phe Leu Tyr Ala Asn 
            500                 505                 510         


Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Ile Ser Asn Gly 
        515                 520                 525             


Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser 
    530                 535                 540                 


Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe 
545                 550                 555                 560 


Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser 
                565                 570                 575     


Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val Glu 
            580                 585                 590         


Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
        595                 600                 605     


<210>  6232
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LINGO4__Homo_sapiens__NP_001004432

<400>  6232

Met Asp Ala Ala Thr Ala Pro Lys Gln Ala Trp Pro Pro Trp Pro Pro 
1               5                   10                  15      


Leu Leu Phe Leu Leu Leu Leu Pro Gly Gly Ser Gly Gly Ser Cys Pro 
            20                  25                  30          


Ala Val Cys Asp Cys Thr Ser Gln Pro Gln Ala Val Leu Cys Gly His 
        35                  40                  45              


Arg Gln Leu Glu Ala Val Pro Gly Gly Leu Pro Leu Asp Thr Glu Leu 
    50                  55                  60                  


Leu Asp Leu Ser Gly Asn Arg Leu Trp Gly Leu Gln Gln Gly Met Leu 
65                  70                  75                  80  


Ser Arg Leu Ser Leu Leu Gln Glu Leu Asp Leu Ser Tyr Asn Gln Leu 
                85                  90                  95      


Ser Thr Leu Glu Pro Gly Ala Phe His Gly Leu Gln Ser Leu Leu Thr 
            100                 105                 110         


Leu Arg Leu Gln Gly Asn Arg Leu Arg Ile Met Gly Pro Gly Val Phe 
        115                 120                 125             


Ser Gly Leu Ser Ala Leu Thr Leu Leu Asp Leu Arg Leu Asn Gln Ile 
    130                 135                 140                 


Val Leu Phe Leu Asp Gly Ala Phe Gly Glu Leu Gly Ser Leu Gln Lys 
145                 150                 155                 160 


Leu Glu Val Gly Asp Asn His Leu Val Phe Val Ala Pro Gly Ala Phe 
                165                 170                 175     


Ala Gly Leu Ala Lys Leu Ser Thr Leu Thr Leu Glu Arg Cys Asn Leu 
            180                 185                 190         


Ser Thr Val Pro Gly Leu Ala Leu Ala Arg Leu Pro Ala Leu Val Ala 
        195                 200                 205             


Leu Arg Leu Arg Glu Leu Asp Ile Gly Arg Leu Pro Ala Gly Ala Leu 
    210                 215                 220                 


Arg Gly Leu Gly Gln Leu Lys Glu Leu Glu Ile His Leu Trp Pro Ser 
225                 230                 235                 240 


Leu Glu Ala Leu Asp Pro Gly Ser Leu Val Gly Leu Asn Leu Ser Ser 
                245                 250                 255     


Leu Ala Ile Thr Arg Cys Asn Leu Ser Ser Val Pro Phe Gln Ala Leu 
            260                 265                 270         


Tyr His Leu Ser Phe Leu Arg Val Leu Asp Leu Ser Gln Asn Pro Ile 
        275                 280                 285             


Ser Ala Ile Pro Ala Arg Arg Leu Ser Pro Leu Val Arg Leu Gln Glu 
    290                 295                 300                 


Leu Arg Leu Ser Gly Ala Cys Leu Thr Ser Ile Ala Ala His Ala Phe 
305                 310                 315                 320 


His Gly Leu Thr Ala Phe His Leu Leu Asp Val Ala Asp Asn Ala Leu 
                325                 330                 335     


Gln Thr Leu Glu Glu Thr Ala Phe Pro Ser Pro Asp Lys Leu Val Thr 
            340                 345                 350         


Leu Arg Leu Ser Gly Asn Pro Leu Thr Cys Asp Cys Arg Leu Leu Trp 
        355                 360                 365             


Leu Leu Arg Leu Arg Arg His Leu Asp Phe Gly Met Ser Pro Pro Ala 
    370                 375                 380                 


Cys Ala Gly Pro His His Val Gln Gly Lys Ser Leu Lys Glu Phe Ser 
385                 390                 395                 400 


Asp Ile Leu Pro Pro Gly His Phe Thr Cys Lys Pro Ala Leu Ile Arg 
                405                 410                 415     


Lys Ser Gly Pro Arg Trp Val Ile Ala Glu Glu Gly Gly His Ala Val 
            420                 425                 430         


Phe Ser Cys Ser Gly Asp Gly Asp Pro Ala Pro Thr Val Ser Trp Met 
        435                 440                 445             


Arg Pro His Gly Ala Trp Leu Gly Arg Ala Gly Arg Val Arg Val Leu 
    450                 455                 460                 


Glu Asp Gly Thr Leu Glu Ile Arg Ser Val Gln Leu Arg Asp Arg Gly 
465                 470                 475                 480 


Ala Tyr Val Cys Val Val Ser Asn Val Ala Gly Asn Asp Ser Leu Arg 
                485                 490                 495     


Thr Trp Leu Glu Val Ile Gln Val Glu Pro Pro Asn Gly Thr Leu Ser 
            500                 505                 510         


Asp Pro Asn Ile Thr Val Pro Gly Ile Pro Gly Pro Phe Phe Leu Asp 
        515                 520                 525             


Ser Arg Gly Val Ala Met Val Leu Ala Val Gly Phe Leu Pro Phe Leu 
    530                 535                 540                 


Thr Ser Val Thr Leu Cys Phe Gly Leu Ile Ala Leu Trp Ser Lys Gly 
545                 550                 555                 560 


Lys Gly Arg Val Lys His His Met Thr Phe Asp Phe Val Ala Pro Arg 
                565                 570                 575     


Pro Ser Gly Asp Lys Asn Ser Gly Gly Asn Arg Val Thr Ala Lys Leu 
            580                 585                 590         


Phe 
    


<210>  6233
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LINS__Homo_sapiens__NP_001035706

<400>  6233

Met Lys Val Phe Cys Glu Val Leu Glu Glu Leu Tyr Lys Lys Val Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu Glu Asn Asp Ser His Asp Tyr Ile Phe Tyr Leu 
            20                  25                  30          


Asn Pro Ala Val Ser Asp Gln Asp Cys Ser Thr Ala Thr Ser Leu Glu 
        35                  40                  45              


Trp Ala Asn Thr Cys Gly Ile Gln Gly Arg His Gln Pro Ile Ser Val 
    50                  55                  60                  


Gly Val Ala Pro Ile Ala Val Ala Pro Val Cys Leu Lys Thr Asn Ser 
65                  70                  75                  80  


Gln Met Ser Gly Ser Arg Glu Val Met Leu Leu Gln Leu Thr Val Ile 
                85                  90                  95      


Lys Val Met Thr Thr Arg Ile Leu Ser Val Lys Thr Glu Phe His Ala 
            100                 105                 110         


Lys Glu Gln Tyr Arg Asp Val Ile Lys Ile Leu Leu Glu Ser Ala Lys 
        115                 120                 125             


Val Asp Ser Lys Leu Ile Cys Met Phe Gln Asn Ser Asp Lys Leu Leu 
    130                 135                 140                 


Ser His Met Ala Ala Gln Cys Leu Ala Leu Leu Leu Tyr Phe Gln Leu 
145                 150                 155                 160 


Arg Glu Lys Ile Thr Leu Ser Asn Ser Trp Ile Ala Phe Cys Gln Lys 
                165                 170                 175     


Asn Leu Ser Glu Tyr Ser Glu Ser Asn Lys Ala Ile Tyr Cys Leu Trp 
            180                 185                 190         


Thr Leu Thr Ala Ile Ile Lys Glu Ile Phe Lys Asp Ser Cys Ser Gln 
        195                 200                 205             


Lys Thr Glu Ile Leu Lys Gln Phe Leu Thr His Phe Asp Thr Ile Phe 
    210                 215                 220                 


Glu Val Phe Tyr Asn Ser Leu Phe Ser Gln His Phe Glu Asn Cys Arg 
225                 230                 235                 240 


Asp Thr Ser Lys Ile Val Asn Ile Leu Met Cys Phe Leu Asp Leu Leu 
                245                 250                 255     


Glu Leu Leu Ile Ala Ser Arg Ile His Leu Lys Leu His Phe Thr Cys 
            260                 265                 270         


Gln Arg Ile Leu Phe Leu Lys Pro Ser Cys Met Leu Glu Val Ile Thr 
        275                 280                 285             


Trp Pro Ile Gln Ala Phe Val Lys Arg Lys Val Ile Ile Phe Leu Lys 
    290                 295                 300                 


Lys Cys Leu Leu Cys Lys Val Gly Glu Asp Leu Cys Arg Gly Ser Val 
305                 310                 315                 320 


Pro Ala Leu Met Pro Pro Asp His His Val Ala Val Asp Met Leu Ala 
                325                 330                 335     


Leu Ala Asn Ala Val Leu Gln Ala Val Asn Ser Gly Leu Leu Lys Thr 
            340                 345                 350         


Leu Ser Val Tyr Glu Lys His Ser Phe Phe Gly Gly Asp Glu Val Gln 
        355                 360                 365             


Pro Glu Cys Glu Leu Ile Thr Ser Pro Asp His Val Ile Leu Arg Ala 
    370                 375                 380                 


Ala Ser Leu Val Ile Met Lys Ser Leu Glu Ile Lys Phe Gln Asn Tyr 
385                 390                 395                 400 


Ser Ser Ala Ser Glu Met Lys Val Asp Leu Gln Arg Phe Met Ser Glu 
                405                 410                 415     


Leu Leu Thr Phe Leu Lys Pro His Leu Gln Pro Ser Leu Gln Leu His 
            420                 425                 430         


Asn Pro Cys Lys Trp Leu Ser Arg Val Phe Ile Glu Gln Asp Asp Asp 
        435                 440                 445             


Met Leu Glu Ala Ala Lys Ala Ser Leu Gly Ile Tyr Leu Thr Leu Thr 
    450                 455                 460                 


Arg Gly Cys Glu Ala Thr Glu Ser Leu Thr Gln Gly Lys Glu Met Trp 
465                 470                 475                 480 


Asp His His Thr His Glu Asn Gly Tyr Asn Pro His Cys Ile Phe Leu 
                485                 490                 495     


Phe Phe Leu Lys Asn Ile Gly Phe Asp Ser Thr Val Leu Leu Asp Phe 
            500                 505                 510         


Leu Ile Ser Ser Glu Thr Cys Phe Leu Glu Tyr Phe Val Arg Tyr Leu 
        515                 520                 525             


Lys Leu Leu Gln Lys Asp Trp Asp Asn Phe Phe Thr Ile Cys Asn Asn 
    530                 535                 540                 


Phe Asp Ala Thr Glu Ser Lys Tyr Asp Ile Ser Ile Cys Gly Cys Val 
545                 550                 555                 560 


Pro Ser Leu Val Gln Asp Gln Ser Ser Asn Gln Thr Ile Pro His Arg 
                565                 570                 575     


Leu Thr Ala Pro His Ser His Arg Asp Val Cys Ala Arg His Ser Trp 
            580                 585                 590         


Ala Ser Asp Ala Pro Ser Glu Pro Leu Lys Ala Val Met Ser Lys Gly 
        595                 600                 605             


Ala His Thr Met Cys Ala Ser Ser Leu Ser Ser Pro Arg Ala Ser Gln 
    610                 615                 620                 


Ser Leu Val Asp Tyr Asp Ser Ser Asp Asp Ser Asp Val Glu Ser Thr 
625                 630                 635                 640 


Glu Gln Cys Leu Ala Asn Ser Lys Gln Thr Ser Leu His Gln Gln Ala 
                645                 650                 655     


Thr Lys Glu Ile Gln Asp Ala Ala Gly Thr Ser Arg Asp Lys Lys Glu 
            660                 665                 670         


Phe Ser Leu Glu Pro Pro Ser Arg Pro Leu Val Leu Lys Glu Phe Asp 
        675                 680                 685             


Thr Ala Phe Ser Phe Asp Cys Glu Val Ala Pro Asn Asp Val Val Ser 
    690                 695                 700                 


Glu Val Gly Ile Phe Tyr Arg Ile Val Lys Cys Phe Gln Glu Leu Gln 
705                 710                 715                 720 


Asp Ala Ile Cys Arg Leu Gln Lys Lys Asn Leu Phe Pro Tyr Asn Pro 
                725                 730                 735     


Thr Ala Leu Leu Lys Leu Leu Lys Tyr Ile Glu Val Ile Ser Asn Lys 
            740                 745                 750         


Thr Met Asn Thr Leu 
        755         


<210>  6234
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPA__Homo_sapiens__NP_000226

<400>  6234

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    210                 215                 220                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
225                 230                 235                 240 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                245                 250                 255     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            260                 265                 270         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        275                 280                 285             


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
    290                 295                 300                 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
305                 310                 315                 320 


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                325                 330                 335     


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
            340                 345                 350         


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
        355                 360                 365             


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
    370                 375                 380                 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
385                 390                 395                 


<210>  6235
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPC__Homo_sapiens__XP_005254429

<400>  6235

Met Asp Thr Ser Pro Leu Cys Phe Ser Ile Leu Leu Val Leu Cys Ile 
1               5                   10                  15      


Phe Ile Gln Ser Ser Ala Leu Gly Gln Ser Leu Lys Pro Glu Pro Phe 
            20                  25                  30          


Gly Arg Arg Ala Gln Ala Val Glu Thr Asn Lys Thr Leu His Glu Met 
        35                  40                  45              


Lys Thr Arg Phe Leu Leu Phe Gly Glu Thr Asn Gln Gly Cys Gln Ile 
    50                  55                  60                  


Arg Ile Asn His Pro Asp Thr Leu Gln Glu Cys Gly Phe Asn Ser Ser 
65                  70                  75                  80  


Leu Pro Leu Val Met Ile Ile His Gly Trp Ser Val Asp Gly Val Leu 
                85                  90                  95      


Glu Asn Trp Ile Trp Gln Met Val Ala Ala Leu Lys Ser Gln Pro Ala 
            100                 105                 110         


Gln Pro Val Asn Val Gly Leu Val Asp Trp Ile Thr Leu Ala His Asp 
        115                 120                 125             


His Tyr Thr Ile Ala Val Arg Asn Thr Arg Leu Val Gly Lys Glu Val 
    130                 135                 140                 


Ala Ala Leu Leu Arg Trp Leu Glu Glu Ser Val Gln Leu Ser Arg Ser 
145                 150                 155                 160 


His Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ser Gly Phe 
                165                 170                 175     


Ala Gly Ser Ser Ile Gly Gly Thr His Lys Ile Gly Arg Ile Thr Gly 
            180                 185                 190         


Leu Asp Ala Ala Gly Pro Leu Phe Glu Gly Ser Ala Pro Ser Asn Arg 
        195                 200                 205             


Leu Ser Pro Asp Asp Ala Asn Phe Val Asp Ala Ile His Thr Phe Thr 
    210                 215                 220                 


Arg Glu His Met Gly Leu Ser Val Gly Ile Lys Gln Pro Ile Gly His 
225                 230                 235                 240 


Tyr Asp Phe Tyr Pro Asn Gly Gly Ser Phe Gln Pro Gly Cys His Phe 
                245                 250                 255     


Leu Glu Leu Tyr Arg His Ile Ala Gln His Gly Phe Asn Ala Ile Thr 
            260                 265                 270         


Gln Thr Ile Lys Cys Ser His Glu Arg Ser Val His Leu Phe Ile Asp 
        275                 280                 285             


Ser Leu Leu His Ala Gly Thr Gln Ser Met Ala Tyr Pro Cys Gly Asp 
    290                 295                 300                 


Met Asn Ser Phe Ser Gln Gly Leu Cys Leu Ser Cys Lys Lys Gly Arg 
305                 310                 315                 320 


Cys Asn Thr Leu Gly Tyr His Val Arg Gln Glu Pro Arg Ser Lys Ser 
                325                 330                 335     


Lys Arg Leu Phe Leu Val Thr Arg Ala Gln Ser Pro Phe Lys Val Tyr 
            340                 345                 350         


His Tyr Gln Phe Lys Ile Gln Phe Ile Asn Gln Thr Glu Thr Pro Ile 
        355                 360                 365             


Gln Thr Thr Phe Thr Met Ser Leu Leu Gly Thr Lys Glu Lys Met Gln 
    370                 375                 380                 


Lys Ile Pro Ile Thr Leu Gly Lys Gly Ile Ala Ser Asn Lys Thr Tyr 
385                 390                 395                 400 


Ser Phe Leu Ile Thr Leu Asp Val Asp Ile Gly Glu Leu Ile Met Ile 
                405                 410                 415     


Lys Phe Lys Trp Glu Asn Ser Ala Val Trp Ala Asn Val Trp Asp Thr 
            420                 425                 430         


Val Gln Thr Ile Ile Pro Trp Ser Thr Gly Pro Arg His Ser Gly Leu 
        435                 440                 445             


Val Leu Lys Thr Ile Arg Val Lys Ala Gly Glu Thr Gln Gln Arg Met 
    450                 455                 460                 


Thr Phe Cys Ser Glu Asn Thr Asp Asp Leu Leu Leu Arg Pro Thr Gln 
465                 470                 475                 480 


Glu Lys Ile Phe Val Lys Cys Glu Ile Lys Ser Lys Thr Ser Lys Arg 
                485                 490                 495     


Lys Ile Arg 
            


<210>  6236
<211>  1076
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPE__Homo_sapiens__NP_005348

<400>  6236

Met Glu Pro Gly Ser Lys Ser Val Ser Arg Ser Asp Trp Gln Pro Glu 
1               5                   10                  15      


Pro His Gln Arg Pro Ile Thr Pro Leu Glu Pro Gly Pro Glu Lys Thr 
            20                  25                  30          


Pro Ile Ala Gln Pro Glu Ser Lys Thr Leu Gln Gly Ser Asn Thr Gln 
        35                  40                  45              


Gln Lys Pro Ala Ser Asn Gln Arg Pro Leu Thr Gln Gln Glu Thr Pro 
    50                  55                  60                  


Ala Gln His Asp Ala Glu Ser Gln Lys Glu Pro Arg Ala Gln Gln Lys 
65                  70                  75                  80  


Ser Ala Ser Gln Glu Glu Phe Leu Ala Pro Gln Lys Pro Ala Pro Gln 
                85                  90                  95      


Gln Ser Pro Tyr Ile Gln Arg Val Leu Leu Thr Gln Gln Glu Ala Ala 
            100                 105                 110         


Ser Gln Gln Gly Pro Gly Leu Gly Lys Glu Ser Ile Thr Gln Gln Glu 
        115                 120                 125             


Pro Ala Leu Arg Gln Arg His Val Ala Gln Pro Gly Pro Gly Pro Gly 
    130                 135                 140                 


Glu Pro Pro Pro Ala Gln Gln Glu Ala Glu Ser Thr Pro Ala Ala Gln 
145                 150                 155                 160 


Ala Lys Pro Gly Ala Lys Arg Glu Pro Ser Ala Pro Thr Glu Ser Thr 
                165                 170                 175     


Ser Gln Glu Thr Pro Glu Gln Ser Asp Lys Gln Thr Thr Pro Val Gln 
            180                 185                 190         


Gly Ala Lys Ser Lys Gln Gly Ser Leu Thr Glu Leu Gly Phe Leu Thr 
        195                 200                 205             


Lys Leu Gln Glu Leu Ser Ile Gln Arg Ser Ala Leu Glu Trp Lys Ala 
    210                 215                 220                 


Leu Ser Glu Trp Val Thr Asp Ser Glu Ser Glu Ser Asp Val Gly Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Asp Ser Pro Ala Thr Met Gly Gly Met Val Ala Gln 
                245                 250                 255     


Gly Val Lys Leu Gly Phe Lys Gly Lys Ser Gly Tyr Lys Val Met Ser 
            260                 265                 270         


Gly Tyr Ser Gly Thr Ser Pro His Glu Lys Thr Ser Ala Arg Asn His 
        275                 280                 285             


Arg His Tyr Gln Asp Thr Ala Ser Arg Leu Ile His Asn Met Asp Leu 
    290                 295                 300                 


Arg Thr Met Thr Gln Ser Leu Val Thr Leu Ala Glu Asp Asn Ile Ala 
305                 310                 315                 320 


Phe Phe Ser Ser Gln Gly Pro Gly Glu Thr Ala Gln Arg Leu Ser Gly 
                325                 330                 335     


Val Phe Ala Gly Val Arg Glu Gln Ala Leu Gly Leu Glu Pro Ala Leu 
            340                 345                 350         


Gly Arg Leu Leu Gly Val Ala His Leu Phe Asp Leu Asp Pro Glu Thr 
        355                 360                 365             


Pro Ala Asn Gly Tyr Arg Ser Leu Val His Thr Ala Arg Cys Cys Leu 
    370                 375                 380                 


Ala His Leu Leu His Lys Ser Arg Tyr Val Ala Ser Asn Arg Arg Ser 
385                 390                 395                 400 


Ile Phe Phe Arg Thr Ser His Asn Leu Ala Glu Leu Glu Ala Tyr Leu 
                405                 410                 415     


Ala Ala Leu Thr Gln Leu Arg Ala Leu Val Tyr Tyr Ala Gln Arg Leu 
            420                 425                 430         


Leu Val Thr Asn Arg Pro Gly Val Leu Phe Phe Glu Gly Asp Glu Gly 
        435                 440                 445             


Leu Thr Ala Asp Phe Leu Arg Glu Tyr Val Thr Leu His Lys Gly Cys 
    450                 455                 460                 


Phe Tyr Gly Arg Cys Leu Gly Phe Gln Phe Thr Pro Ala Ile Arg Pro 
465                 470                 475                 480 


Phe Leu Gln Thr Ile Ser Ile Gly Leu Val Ser Phe Gly Glu His Tyr 
                485                 490                 495     


Lys Arg Asn Glu Thr Gly Leu Ser Val Ala Ala Ser Ser Leu Phe Thr 
            500                 505                 510         


Ser Gly Arg Phe Ala Ile Asp Pro Glu Leu Arg Gly Ala Glu Phe Glu 
        515                 520                 525             


Arg Ile Thr Gln Asn Leu Asp Val His Phe Trp Lys Ala Phe Trp Asn 
    530                 535                 540                 


Ile Thr Glu Met Glu Val Leu Ser Ser Leu Ala Asn Met Ala Ser Ala 
545                 550                 555                 560 


Thr Val Arg Val Ser Arg Leu Leu Ser Leu Pro Pro Glu Ala Phe Glu 
                565                 570                 575     


Met Pro Leu Thr Ala Asp Pro Thr Leu Thr Val Thr Ile Ser Pro Pro 
            580                 585                 590         


Leu Ala His Thr Gly Pro Gly Pro Val Leu Val Arg Leu Ile Ser Tyr 
        595                 600                 605             


Asp Leu Arg Glu Gly Gln Asp Ser Glu Glu Leu Ser Ser Leu Ile Lys 
    610                 615                 620                 


Ser Asn Gly Gln Arg Ser Leu Glu Leu Trp Pro Arg Pro Gln Gln Ala 
625                 630                 635                 640 


Pro Arg Ser Arg Ser Leu Ile Val His Phe His Gly Gly Gly Phe Val 
                645                 650                 655     


Ala Gln Thr Ser Arg Ser His Glu Pro Tyr Leu Lys Ser Trp Ala Gln 
            660                 665                 670         


Glu Leu Gly Ala Pro Ile Ile Ser Ile Asp Tyr Ser Leu Ala Pro Glu 
        675                 680                 685             


Ala Pro Phe Pro Arg Ala Leu Glu Glu Cys Phe Phe Ala Tyr Cys Trp 
    690                 695                 700                 


Ala Ile Lys His Cys Ala Leu Leu Gly Ser Thr Gly Glu Arg Ile Cys 
705                 710                 715                 720 


Leu Ala Gly Asp Ser Ala Gly Gly Asn Leu Cys Phe Thr Val Ala Leu 
                725                 730                 735     


Arg Ala Ala Ala Tyr Gly Val Arg Val Pro Asp Gly Ile Met Ala Ala 
            740                 745                 750         


Tyr Pro Ala Thr Met Leu Gln Pro Ala Ala Ser Pro Ser Arg Leu Leu 
        755                 760                 765             


Ser Leu Met Asp Pro Leu Leu Pro Leu Ser Val Leu Ser Lys Cys Val 
    770                 775                 780                 


Ser Ala Tyr Ala Gly Ala Lys Thr Glu Asp His Ser Asn Ser Asp Gln 
785                 790                 795                 800 


Lys Ala Leu Gly Met Met Gly Leu Val Arg Arg Asp Thr Ala Leu Leu 
                805                 810                 815     


Leu Arg Asp Phe Arg Leu Gly Ala Ser Ser Trp Leu Asn Ser Phe Leu 
            820                 825                 830         


Glu Leu Ser Gly Arg Lys Ser Gln Lys Met Ser Glu Pro Ile Ala Glu 
        835                 840                 845             


Pro Met Arg Arg Ser Val Ser Glu Ala Ala Leu Ala Gln Pro Gln Gly 
    850                 855                 860                 


Pro Leu Gly Thr Asp Ser Leu Lys Asn Leu Thr Leu Arg Asp Leu Ser 
865                 870                 875                 880 


Leu Arg Gly Asn Ser Glu Thr Ser Ser Asp Thr Pro Glu Met Ser Leu 
                885                 890                 895     


Ser Ala Glu Thr Leu Ser Pro Ser Thr Pro Ser Asp Val Asn Phe Leu 
            900                 905                 910         


Leu Pro Pro Glu Asp Ala Gly Glu Glu Ala Glu Ala Lys Asn Glu Leu 
        915                 920                 925             


Ser Pro Met Asp Arg Gly Leu Gly Val Arg Ala Ala Phe Pro Glu Gly 
    930                 935                 940                 


Phe His Pro Arg Arg Ser Ser Gln Gly Ala Thr Gln Met Pro Leu Tyr 
945                 950                 955                 960 


Ser Ser Pro Ile Val Lys Asn Pro Phe Met Ser Pro Leu Leu Ala Pro 
                965                 970                 975     


Asp Ser Met Leu Lys Ser Leu Pro Pro Val His Ile Val Ala Cys Ala 
            980                 985                 990         


Leu Asp Pro Met Leu Asp Asp Ser  Val Met Leu Ala Arg  Arg Leu Arg 
        995                 1000                 1005             


Asn Leu  Gly Gln Pro Val Thr  Leu Arg Val Val Glu  Asp Leu Pro 
    1010                 1015                 1020             


His Gly  Phe Leu Thr Leu Ala  Ala Leu Cys Arg Glu  Thr Arg Gln 
    1025                 1030                 1035             


Ala Ala  Glu Leu Cys Val Glu  Arg Ile Arg Leu Val  Leu Thr Pro 
    1040                 1045                 1050             


Pro Ala  Gly Ala Gly Pro Ser  Gly Glu Thr Gly Ala  Ala Gly Val 
    1055                 1060                 1065             


Asp Gly  Gly Cys Gly Gly Arg  His 
    1070                 1075     


<210>  6237
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPF__Homo_sapiens__NP_001185757

<400>  6237

Met Trp Leu Leu Leu Thr Met Ala Ser Leu Ile Ser Val Leu Gly Thr 
1               5                   10                  15      


Thr His Gly Leu Phe Gly Lys Leu His Pro Gly Ser Pro Glu Val Thr 
            20                  25                  30          


Met Asn Ile Ser Gln Met Ile Thr Tyr Trp Gly Tyr Pro Asn Glu Glu 
        35                  40                  45              


Tyr Glu Val Val Thr Glu Asp Gly Tyr Ile Leu Glu Val Asn Arg Ile 
    50                  55                  60                  


Pro Tyr Gly Lys Lys Asn Ser Gly Asn Thr Asp Ala Gly Tyr Asp Val 
65                  70                  75                  80  


Trp Leu Gly Asn Ser Arg Gly Asn Thr Trp Ala Arg Arg Asn Leu Tyr 
                85                  90                  95      


Tyr Ser Pro Asp Ser Val Glu Phe Trp Ala Phe Ser Phe Asp Glu Met 
            100                 105                 110         


Ala Lys Tyr Asp Leu Pro Ala Thr Ile Asp Phe Ile Val Lys Lys Thr 
        115                 120                 125             


Gly Gln Lys Gln Leu His Tyr Val Gly His Ser Gln Gly Thr Thr Ile 
    130                 135                 140                 


Gly Phe Ile Ala Phe Ser Thr Asn Pro Ser Leu Ala Lys Arg Ile Lys 
145                 150                 155                 160 


Thr Phe Tyr Ala Leu Ala Pro Val Ala Thr Val Lys Tyr Thr Lys Ser 
                165                 170                 175     


Leu Ile Asn Lys Leu Arg Phe Val Pro Gln Ser Leu Phe Lys Phe Ile 
            180                 185                 190         


Phe Gly Asp Lys Ile Phe Tyr Pro His Asn Phe Phe Asp Gln Phe Leu 
        195                 200                 205             


Ala Thr Glu Val Cys Ser Arg Glu Met Leu Asn Leu Leu Cys Ser Asn 
    210                 215                 220                 


Ala Leu Phe Ile Ile Cys Gly Phe Asp Ser Lys Asn Phe Asn Thr Ser 
225                 230                 235                 240 


Arg Leu Asp Val Tyr Leu Ser His Asn Pro Ala Gly Thr Ser Val Gln 
                245                 250                 255     


Asn Met Phe His Trp Thr Gln Ala Val Lys Ser Gly Lys Phe Gln Ala 
            260                 265                 270         


Tyr Asp Trp Gly Ser Pro Val Gln Asn Arg Met His Tyr Asp Gln Ser 
        275                 280                 285             


Gln Pro Pro Tyr Tyr Asn Val Thr Ala Met Asn Val Pro Ile Ala Val 
    290                 295                 300                 


Trp Asn Gly Gly Lys Asp Leu Leu Ala Asp Pro Gln Asp Val Gly Leu 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Pro Asn Leu Ile Tyr His Lys Glu Ile Pro Phe 
                325                 330                 335     


Tyr Asn His Leu Asp Phe Ile Trp Ala Met Asp Ala Pro Gln Glu Val 
            340                 345                 350         


Tyr Asn Asp Ile Val Ser Met Ile Ser Glu Asp Lys Lys 
        355                 360                 365 


<210>  6238
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPG__Homo_sapiens__NP_006024

<400>  6238

Met Ser Asn Ser Val Pro Leu Leu Cys Phe Trp Ser Leu Cys Tyr Cys 
1               5                   10                  15      


Phe Ala Ala Gly Ser Pro Val Pro Phe Gly Pro Glu Gly Arg Leu Glu 
            20                  25                  30          


Asp Lys Leu His Lys Pro Lys Ala Thr Gln Thr Glu Val Lys Pro Ser 
        35                  40                  45              


Val Arg Phe Asn Leu Arg Thr Ser Lys Asp Pro Glu His Glu Gly Cys 
    50                  55                  60                  


Tyr Leu Ser Val Gly His Ser Gln Pro Leu Glu Asp Cys Ser Phe Asn 
65                  70                  75                  80  


Met Thr Ala Lys Thr Phe Phe Ile Ile His Gly Trp Thr Met Ser Gly 
                85                  90                  95      


Ile Phe Glu Asn Trp Leu His Lys Leu Val Ser Ala Leu His Thr Arg 
            100                 105                 110         


Glu Lys Asp Ala Asn Val Val Val Val Asp Trp Leu Pro Leu Ala His 
        115                 120                 125             


Gln Leu Tyr Thr Asp Ala Val Asn Asn Thr Arg Val Val Gly His Ser 
    130                 135                 140                 


Ile Ala Arg Met Leu Asp Trp Leu Gln Glu Lys Asp Asp Phe Ser Leu 
145                 150                 155                 160 


Gly Asn Val His Leu Ile Gly Tyr Ser Leu Gly Ala His Val Ala Gly 
                165                 170                 175     


Tyr Ala Gly Asn Phe Val Lys Gly Thr Val Gly Arg Ile Thr Gly Leu 
            180                 185                 190         


Asp Pro Ala Gly Pro Met Phe Glu Gly Ala Asp Ile His Lys Arg Leu 
        195                 200                 205             


Ser Pro Asp Asp Ala Asp Phe Val Asp Val Leu His Thr Tyr Thr Arg 
    210                 215                 220                 


Ser Phe Gly Leu Ser Ile Gly Ile Gln Met Pro Val Gly His Ile Asp 
225                 230                 235                 240 


Ile Tyr Pro Asn Gly Gly Asp Phe Gln Pro Gly Cys Gly Leu Asn Asp 
                245                 250                 255     


Val Leu Gly Ser Ile Ala Tyr Gly Thr Ile Thr Glu Val Val Lys Cys 
            260                 265                 270         


Glu His Glu Arg Ala Val His Leu Phe Val Asp Ser Leu Val Asn Gln 
        275                 280                 285             


Asp Lys Pro Ser Phe Ala Phe Gln Cys Thr Asp Ser Asn Arg Phe Lys 
    290                 295                 300                 


Lys Gly Ile Cys Leu Ser Cys Arg Lys Asn Arg Cys Asn Ser Ile Gly 
305                 310                 315                 320 


Tyr Asn Ala Lys Lys Met Arg Asn Lys Arg Asn Ser Lys Met Tyr Leu 
                325                 330                 335     


Lys Thr Arg Ala Gly Met Pro Phe Arg Val Tyr His Tyr Gln Met Lys 
            340                 345                 350         


Ile His Val Phe Ser Tyr Lys Asn Met Gly Glu Ile Glu Pro Thr Phe 
        355                 360                 365             


Tyr Val Thr Leu Tyr Gly Thr Asn Ala Asp Ser Gln Thr Leu Pro Leu 
    370                 375                 380                 


Glu Ile Val Glu Arg Ile Glu Gln Asn Ala Thr Asn Thr Phe Leu Val 
385                 390                 395                 400 


Tyr Thr Glu Glu Asp Leu Gly Asp Leu Leu Lys Ile Gln Leu Thr Trp 
                405                 410                 415     


Glu Gly Ala Ser Gln Ser Trp Tyr Asn Leu Trp Lys Glu Phe Arg Ser 
            420                 425                 430         


Tyr Leu Ser Gln Pro Arg Asn Pro Gly Arg Glu Leu Asn Ile Arg Arg 
        435                 440                 445             


Ile Arg Val Lys Ser Gly Glu Thr Gln Arg Lys Leu Thr Phe Cys Thr 
    450                 455                 460                 


Glu Asp Pro Glu Asn Thr Ser Ile Ser Pro Gly Arg Glu Leu Trp Phe 
465                 470                 475                 480 


Arg Lys Cys Arg Asp Gly Trp Arg Met Lys Asn Glu Thr Ser Pro Thr 
                485                 490                 495     


Val Glu Leu Pro 
            500 


<210>  6239
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPH__Homo_sapiens__NP_640341

<400>  6239

Met Leu Arg Phe Tyr Leu Phe Ile Ser Leu Leu Cys Leu Ser Arg Ser 
1               5                   10                  15      


Asp Ala Glu Glu Thr Cys Pro Ser Phe Thr Arg Leu Ser Phe His Ser 
            20                  25                  30          


Ala Val Val Gly Thr Gly Leu Asn Val Arg Leu Met Leu Tyr Thr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Ala Gln Thr Ile Asn Ser Ser Ala Phe Gly Asn 
    50                  55                  60                  


Leu Asn Val Thr Lys Lys Thr Thr Phe Ile Val His Gly Phe Arg Pro 
65                  70                  75                  80  


Thr Gly Ser Pro Pro Val Trp Met Asp Asp Leu Val Lys Gly Leu Leu 
                85                  90                  95      


Ser Val Glu Asp Met Asn Val Val Val Val Asp Trp Asn Arg Gly Ala 
            100                 105                 110         


Thr Thr Leu Ile Tyr Thr His Ala Ser Ser Lys Thr Arg Lys Val Ala 
        115                 120                 125             


Met Val Leu Lys Glu Phe Ile Asp Gln Met Leu Ala Glu Gly Ala Ser 
    130                 135                 140                 


Leu Asp Asp Ile Tyr Met Ile Gly Val Ser Leu Gly Ala His Ile Ser 
145                 150                 155                 160 


Gly Phe Val Gly Glu Met Tyr Asp Gly Trp Leu Gly Arg Ile Thr Gly 
                165                 170                 175     


Leu Asp Pro Ala Gly Pro Leu Phe Asn Gly Lys Pro His Gln Asp Arg 
            180                 185                 190         


Leu Asp Pro Ser Asp Ala Gln Phe Val Asp Val Ile His Ser Asp Thr 
        195                 200                 205             


Asp Ala Leu Gly Tyr Lys Glu Pro Leu Gly Asn Ile Asp Phe Tyr Pro 
    210                 215                 220                 


Asn Gly Gly Leu Asp Gln Pro Gly Cys Pro Lys Thr Ile Leu Gly Gly 
225                 230                 235                 240 


Phe Gln Tyr Phe Lys Cys Asp His Gln Arg Ser Val Tyr Leu Tyr Leu 
                245                 250                 255     


Ser Ser Leu Arg Glu Ser Cys Thr Ile Thr Ala Tyr Pro Cys Asp Ser 
            260                 265                 270         


Tyr Gln Asp Tyr Arg Asn Gly Lys Cys Val Ser Cys Gly Thr Ser Gln 
        275                 280                 285             


Lys Glu Ser Cys Pro Leu Leu Gly Tyr Tyr Ala Asp Asn Trp Lys Asp 
    290                 295                 300                 


His Leu Arg Gly Lys Asp Pro Pro Met Thr Lys Ala Phe Phe Asp Thr 
305                 310                 315                 320 


Ala Glu Glu Ser Pro Phe Cys Met Tyr His Tyr Phe Val Asp Ile Ile 
                325                 330                 335     


Thr Trp Asn Lys Asn Val Arg Arg Gly Asp Ile Thr Ile Lys Leu Arg 
            340                 345                 350         


Asp Lys Ala Gly Asn Thr Thr Glu Ser Lys Ile Asn His Glu Pro Thr 
        355                 360                 365             


Thr Phe Gln Lys Tyr His Gln Val Ser Leu Leu Ala Arg Phe Asn Gln 
    370                 375                 380                 


Asp Leu Asp Lys Val Ala Ala Ile Ser Leu Met Phe Ser Thr Gly Ser 
385                 390                 395                 400 


Leu Ile Gly Pro Arg Tyr Lys Leu Arg Ile Leu Arg Met Lys Leu Arg 
                405                 410                 415     


Ser Leu Ala His Pro Glu Arg Pro Gln Leu Cys Arg Tyr Asp Leu Val 
            420                 425                 430         


Leu Met Glu Asn Val Glu Thr Val Phe Gln Pro Ile Leu Cys Pro Glu 
        435                 440                 445             


Leu Gln Leu 
    450     


<210>  6240
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPI__Homo_sapiens__NP_001289927

<400>  6240

Met Arg Val Tyr Ile Phe Leu Cys Leu Met Cys Trp Val Arg Ser Asp 
1               5                   10                  15      


Asn Lys Arg Pro Cys Leu Glu Phe Ser Gln Leu Ser Val Lys Asp Ser 
            20                  25                  30          


Phe Arg Asp Leu Phe Ile Pro Arg Ile Glu Thr Ile Leu Met Met Tyr 
        35                  40                  45              


Thr Arg Asn Asn Leu Asn Cys Ala Glu Pro Leu Phe Glu Gln Asn Asn 
    50                  55                  60                  


Ser Leu Asn Val Asn Phe Asn Thr Gln Lys Lys Thr Val Trp Leu Ile 
65                  70                  75                  80  


His Gly Tyr Arg Pro Val Gly Ser Ile Pro Leu Trp Leu Gln Asn Phe 
                85                  90                  95      


Val Arg Ile Leu Leu Asn Glu Glu Asp Met Asn Val Ile Val Val Asp 
            100                 105                 110         


Trp Ser Arg Gly Ala Thr Thr Phe Ile Tyr Asn Arg Ala Val Lys Asn 
        115                 120                 125             


Thr Arg Lys Val Ala Val Ser Leu Ser Val His Ile Lys Asn Leu Leu 
    130                 135                 140                 


Lys His Gly Ala Ser Leu Asp Asn Phe His Phe Ile Gly Val Ser Leu 
145                 150                 155                 160 


Gly Ala His Ile Ser Gly Phe Val Gly Lys Ile Phe His Gly Gln Leu 
                165                 170                 175     


Gly Arg Ile Thr Gly Leu Asp Pro Ala Gly Pro Arg Phe Ser Arg Lys 
            180                 185                 190         


Pro Pro Tyr Ser Arg Leu Asp Tyr Thr Asp Ala Lys Phe Val Asp Val 
        195                 200                 205             


Ile His Ser Asp Ser Asn Gly Leu Gly Ile Gln Glu Pro Leu Gly His 
    210                 215                 220                 


Ile Asp Phe Tyr Pro Asn Gly Gly Asn Lys Gln Pro Gly Cys Pro Lys 
225                 230                 235                 240 


Ser Ile Phe Ser Gly Ile Gln Phe Ile Lys Cys Asn His Gln Arg Ala 
                245                 250                 255     


Val His Leu Phe Met Ala Ser Leu Glu Thr Asn Cys Asn Phe Ile Ser 
            260                 265                 270         


Phe Pro Cys Arg Ser Tyr Lys Asp Tyr Lys Thr Ser Leu Cys Val Asp 
        275                 280                 285             


Cys Asp Cys Phe Lys Glu Lys Ser Cys Pro Arg Leu Gly Tyr Gln Ala 
    290                 295                 300                 


Lys Leu Phe Lys Gly Val Leu Lys Glu Arg Met Glu Gly Arg Pro Leu 
305                 310                 315                 320 


Arg Thr Thr Val Phe Leu Asp Thr Ser Gly Thr Tyr Pro Phe Cys Thr 
                325                 330                 335     


Tyr Tyr Phe Val Leu Ser Ile Ile Val Pro Asp Lys Thr Met Met Asp 
            340                 345                 350         


Gly Ser Phe Ser Phe Lys Leu Leu Asn Gln Leu Gly Met Ile Glu Glu 
        355                 360                 365             


Pro Arg Leu Tyr Glu Lys Asn Lys Pro Phe Tyr Lys Leu Gln Glu Val 
    370                 375                 380                 


Lys Ile Leu Ala Gln Phe Tyr Asn Asp Phe Val Asn Ile Ser Ser Ile 
385                 390                 395                 400 


Gly Leu Thr Tyr Phe Gln Ser Ser Asn Leu Gln Cys Ser Thr Cys Thr 
                405                 410                 415     


Tyr Lys Ile Gln Ser Leu Met Leu Lys Ser Leu Thr Tyr Pro Glu Arg 
            420                 425                 430         


Pro Pro Leu Cys Arg Tyr Asn Ile Val Leu Lys Asp Arg Glu Glu Val 
        435                 440                 445             


Phe Leu Asn Pro Asn Thr Cys Thr Pro Lys Asn Thr 
    450                 455                 460 


<210>  6241
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPN__Homo_sapiens__NP_001095939

<400>  6241

Met Met Trp Leu Leu Leu Thr Thr Thr Cys Leu Ile Cys Gly Thr Leu 
1               5                   10                  15      


Asn Ala Gly Gly Phe Leu Asp Leu Glu Asn Glu Val Asn Pro Glu Val 
            20                  25                  30          


Trp Met Asn Thr Ser Glu Ile Ile Ile Tyr Asn Gly Tyr Pro Ser Glu 
        35                  40                  45              


Glu Tyr Glu Val Thr Thr Glu Asp Gly Tyr Ile Leu Leu Val Asn Arg 
    50                  55                  60                  


Ile Pro Tyr Gly Arg Thr His Ala Arg Ser Thr Gly Pro Arg Pro Val 
65                  70                  75                  80  


Val Tyr Met Gln His Ala Leu Phe Ala Asp Asn Ala Tyr Trp Leu Glu 
                85                  90                  95      


Asn Tyr Ala Asn Gly Ser Leu Gly Phe Leu Leu Ala Asp Ala Gly Tyr 
            100                 105                 110         


Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Arg His 
        115                 120                 125             


Lys Thr Leu Ser Glu Thr Asp Glu Lys Phe Trp Ala Phe Ser Phe Asp 
    130                 135                 140                 


Glu Met Ala Lys Tyr Asp Leu Pro Gly Val Ile Asp Phe Ile Val Asn 
145                 150                 155                 160 


Lys Thr Gly Gln Glu Lys Leu Tyr Phe Ile Gly His Ser Leu Gly Thr 
                165                 170                 175     


Thr Ile Gly Phe Val Ala Phe Ser Thr Met Pro Glu Leu Ala Gln Arg 
            180                 185                 190         


Ile Lys Met Asn Phe Ala Leu Gly Pro Thr Ile Ser Phe Lys Tyr Pro 
        195                 200                 205             


Thr Gly Ile Phe Thr Arg Phe Phe Leu Leu Pro Asn Ser Ile Ile Lys 
    210                 215                 220                 


Ala Val Phe Gly Thr Lys Gly Phe Phe Leu Glu Asp Lys Lys Thr Lys 
225                 230                 235                 240 


Ile Ala Ser Thr Lys Ile Cys Asn Asn Lys Ile Leu Trp Leu Ile Cys 
                245                 250                 255     


Ser Glu Phe Met Ser Leu Trp Ala Gly Ser Asn Lys Lys Asn Met Asn 
            260                 265                 270         


Gln Ser Arg Met Asp Val Tyr Met Ser His Ala Pro Thr Gly Ser Ser 
        275                 280                 285             


Val His Asn Ile Leu His Ile Lys Gln Leu Tyr His Ser Asp Glu Phe 
    290                 295                 300                 


Arg Ala Tyr Asp Trp Gly Asn Asp Ala Asp Asn Met Lys His Tyr Asn 
305                 310                 315                 320 


Gln Ser His Pro Pro Ile Tyr Asp Leu Thr Ala Met Lys Val Pro Thr 
                325                 330                 335     


Ala Ile Trp Ala Gly Gly His Asp Val Leu Val Thr Pro Gln Asp Val 
            340                 345                 350         


Ala Arg Ile Leu Pro Gln Ile Lys Ser Leu His Tyr Phe Lys Leu Leu 
        355                 360                 365             


Pro Asp Trp Asn His Phe Asp Phe Val Trp Gly Leu Asp Ala Pro Gln 
    370                 375                 380                 


Arg Met Tyr Ser Glu Ile Ile Ala Leu Met Lys Ala Tyr Ser 
385                 390                 395             


<210>  6242
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPT1__Homo_sapiens__NP_057013

<400>  6242

Met Leu Ile Pro Phe Ser Met Lys Asn Cys Phe Gln Leu Leu Cys Asn 
1               5                   10                  15      


Cys Gln Val Pro Ala Ala Gly Phe Lys Lys Thr Val Lys Asn Gly Leu 
            20                  25                  30          


Ile Leu Gln Ser Ile Ser Asn Asp Val Tyr Gln Asn Leu Ala Val Glu 
        35                  40                  45              


Asp Trp Ile His Asp His Met Asn Leu Glu Gly Lys Pro Ile Leu Phe 
    50                  55                  60                  


Phe Trp Gln Asn Ser Pro Ser Val Val Ile Gly Arg His Gln Asn Pro 
65                  70                  75                  80  


Trp Gln Glu Cys Asn Leu Asn Leu Met Arg Glu Glu Gly Ile Lys Leu 
                85                  90                  95      


Ala Arg Arg Arg Ser Gly Gly Gly Thr Val Tyr His Asp Met Gly Asn 
            100                 105                 110         


Ile Asn Leu Thr Phe Phe Thr Thr Lys Lys Lys Tyr Asp Arg Met Glu 
        115                 120                 125             


Asn Leu Lys Leu Ile Val Arg Ala Leu Asn Ala Val Gln Pro Gln Leu 
    130                 135                 140                 


Asp Val Gln Ala Thr Lys Arg Phe Asp Leu Leu Leu Asp Gly Gln Phe 
145                 150                 155                 160 


Lys Ile Ser Gly Thr Ala Ser Lys Ile Gly Arg Thr Thr Ala Tyr His 
                165                 170                 175     


His Cys Thr Leu Leu Cys Ser Thr Asp Gly Thr Phe Leu Ser Ser Leu 
            180                 185                 190         


Leu Lys Ser Pro Tyr Gln Gly Ile Arg Ser Asn Ala Thr Ala Ser Ile 
        195                 200                 205             


Pro Ser Leu Val Lys Asn Leu Leu Glu Lys Asp Pro Thr Leu Thr Cys 
    210                 215                 220                 


Glu Val Leu Met Asn Ala Val Ala Thr Glu Tyr Ala Ala Tyr His Gln 
225                 230                 235                 240 


Ile Asp Asn His Ile His Leu Ile Asn Pro Thr Asp Glu Thr Leu Phe 
                245                 250                 255     


Pro Gly Ile Asn Ser Lys Ala Lys Glu Leu Gln Thr Trp Glu Trp Ile 
            260                 265                 270         


Tyr Gly Lys Thr Pro Lys Phe Ser Ile Asn Thr Ser Phe His Val Leu 
        275                 280                 285             


Tyr Glu Gln Ser His Leu Glu Ile Lys Val Phe Ile Asp Ile Lys Asn 
    290                 295                 300                 


Gly Arg Ile Glu Ile Cys Asn Ile Glu Ala Pro Asp His Trp Leu Pro 
305                 310                 315                 320 


Leu Glu Ile Arg Asp Lys Leu Asn Ser Ser Leu Ile Gly Ser Lys Phe 
                325                 330                 335     


Cys Pro Thr Glu Thr Thr Met Leu Thr Asn Ile Leu Leu Arg Thr Cys 
            340                 345                 350         


Pro Gln Asp His Lys Leu Asn Ser Lys Trp Asn Ile Leu Cys Glu Lys 
        355                 360                 365             


Ile Lys Gly Ile Met 
    370             


<210>  6243
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIPT2__Homo_sapiens__NP_001138341

<400>  6243

Met Arg Gln Pro Ala Val Arg Leu Val Arg Leu Gly Arg Val Pro Tyr 
1               5                   10                  15      


Ala Glu Leu Leu Gly Leu Gln Asp Arg Trp Leu Arg Arg Leu Gln Ala 
            20                  25                  30          


Glu Pro Gly Ile Glu Ala Pro Ser Gly Thr Glu Ala Gly Ala Leu Leu 
        35                  40                  45              


Leu Cys Glu Pro Ala Gly Pro Val Tyr Thr Ala Gly Leu Arg Gly Gly 
    50                  55                  60                  


Leu Thr Pro Glu Glu Thr Ala Arg Leu Arg Ala Leu Gly Ala Glu Val 
65                  70                  75                  80  


Arg Val Thr Gly Arg Gly Gly Leu Ala Thr Phe His Gly Pro Gly Gln 
                85                  90                  95      


Leu Leu Cys His Pro Val Leu Asp Leu Arg Arg Leu Gly Leu Arg Leu 
            100                 105                 110         


Arg Met His Val Ala Ser Leu Glu Ala Cys Ala Val Arg Leu Cys Glu 
        115                 120                 125             


Leu Gln Gly Leu Gln Asp Ala Arg Ala Arg Pro Pro Pro Tyr Thr Gly 
    130                 135                 140                 


Val Trp Leu Asp Asp Arg Lys Ile Cys Ala Ile Gly Val Arg Cys Gly 
145                 150                 155                 160 


Arg His Ile Thr Ser His Gly Leu Ala Leu Asn Cys Ser Thr Asp Leu 
                165                 170                 175     


Thr Trp Phe Glu His Ile Val Pro Cys Gly Leu Val Gly Thr Gly Val 
            180                 185                 190         


Thr Ser Leu Ser Lys Glu Leu Gln Arg His Val Thr Val Glu Glu Val 
        195                 200                 205             


Met Pro Pro Phe Leu Val Ala Phe Lys Glu Ile Tyr Lys Cys Thr Leu 
    210                 215                 220                 


Ile Ser Glu Asp Ser Pro Asn 
225                 230     


<210>  6244
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LITAF__Homo_sapiens__NP_001129945

<400>  6244

Met Ser Val Pro Gly Pro Tyr Gln Ala Ala Thr Gly Pro Ser Ser Ala 
1               5                   10                  15      


Pro Ser Ala Pro Pro Ser Tyr Glu Glu Thr Val Ala Val Asn Ser Tyr 
            20                  25                  30          


Tyr Pro Thr Pro Pro Ala Pro Met Pro Gly Pro Thr Thr Gly Leu Val 
        35                  40                  45              


Thr Gly Pro Asp Gly Lys Gly Met Asn Pro Pro Ser Tyr Tyr Thr Gln 
    50                  55                  60                  


Pro Ala Pro Ile Pro Asn Asn Asn Pro Ile Thr Val Gln Thr Val Tyr 
65                  70                  75                  80  


Val Gln His Pro Ile Thr Phe Leu Asp Arg Pro Ile Gln Met Cys Cys 
                85                  90                  95      


Pro Ser Cys Asn Lys Met Ile Val Ser Gln Leu Ser Tyr Asn Ala Gly 
            100                 105                 110         


Ala Leu Thr Trp Leu Ser Cys Gly Ser Leu Cys Leu Leu Gly Gln Glu 
        115                 120                 125             


Cys Ser Gly Thr Ile Val Ala Leu Arg Ser Phe Asp Leu Leu Gly Ser 
    130                 135                 140                 


Cys Asn Pro Pro Ser Ser Ala Ser 
145                 150         


<210>  6245
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIX1__Homo_sapiens__NP_694966

<400>  6245

Met Asp Arg Thr Leu Glu Ser Leu Arg His Ile Ile Ala Gln Val Leu 
1               5                   10                  15      


Pro His Arg Asp Pro Ala Leu Val Phe Lys Asp Leu Asn Val Val Ser 
            20                  25                  30          


Met Leu Gln Glu Phe Trp Glu Ser Lys Gln Gln Gln Lys Ala Ala Phe 
        35                  40                  45              


Pro Ser Glu Gly Val Val Val Tyr Glu Ser Leu Pro Ala Pro Gly Pro 
    50                  55                  60                  


Pro Phe Val Ser Tyr Val Thr Leu Pro Gly Gly Ser Cys Phe Gly Asn 
65                  70                  75                  80  


Phe Gln Cys Cys Leu Ser Arg Ala Glu Ala Arg Arg Asp Ala Ala Lys 
                85                  90                  95      


Val Ala Leu Ile Asn Ser Leu Phe Asn Glu Leu Pro Ser Arg Arg Ile 
            100                 105                 110         


Thr Lys Glu Phe Ile Met Glu Ser Val Gln Glu Ala Val Ala Ser Thr 
        115                 120                 125             


Ser Gly Thr Leu Asp Asp Ala Asp Asp Pro Ser Thr Ser Val Gly Ala 
    130                 135                 140                 


Tyr His Tyr Met Leu Glu Ser Asn Met Gly Lys Thr Met Leu Glu Phe 
145                 150                 155                 160 


Gln Glu Leu Met Thr Ile Phe Gln Leu Leu His Trp Asn Gly Ser Leu 
                165                 170                 175     


Lys Ala Leu Arg Glu Thr Lys Cys Ser Arg Gln Glu Val Ile Ser Tyr 
            180                 185                 190         


Tyr Ser Gln Tyr Ser Leu Asp Glu Lys Met Arg Ser His Met Ala Leu 
        195                 200                 205             


Asp Trp Ile Met Lys Glu Arg Asp Ser Pro Gly Ile Val Ser Gln Glu 
    210                 215                 220                 


Leu Arg Met Ala Leu Arg Gln Leu Glu Glu Ala Arg Lys Ala Gly Gln 
225                 230                 235                 240 


Glu Leu Arg Phe Tyr Lys Glu Lys Lys Glu Ile Leu Ser Leu Ala Leu 
                245                 250                 255     


Thr Gln Ile Cys Ser Asp Pro Asp Thr Ser Ser Pro Ser Asp Asp Gln 
            260                 265                 270         


Leu Ser Leu Thr Ala Leu Cys Gly Tyr His 
        275                 280         


<210>  6246
<211>  1064
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LLGL1__Homo_sapiens__NP_004131

<400>  6246

Met Met Lys Phe Arg Phe Arg Arg Gln Gly Ala Asp Pro Gln Arg Glu 
1               5                   10                  15      


Lys Leu Lys Gln Glu Leu Phe Ala Phe Asn Lys Thr Val Glu His Gly 
            20                  25                  30          


Phe Pro Asn Gln Pro Ser Ala Leu Ala Phe Asp Pro Glu Leu Arg Ile 
        35                  40                  45              


Met Ala Ile Gly Thr Arg Ser Gly Ala Val Lys Ile Tyr Gly Ala Pro 
    50                  55                  60                  


Gly Val Glu Phe Thr Gly Leu His Arg Asp Ala Ala Thr Val Thr Gln 
65                  70                  75                  80  


Met His Phe Leu Thr Gly Gln Gly Arg Leu Leu Ser Leu Leu Asp Asp 
                85                  90                  95      


Ser Ser Leu His Leu Trp Glu Ile Val His His Asn Gly Cys Ala His 
            100                 105                 110         


Leu Glu Glu Ala Leu Ser Phe Gln Leu Pro Ser Arg Pro Gly Phe Asp 
        115                 120                 125             


Gly Ala Ser Ala Pro Leu Ser Leu Thr Arg Val Thr Val Val Leu Leu 
    130                 135                 140                 


Val Ala Ala Gly Asp Ile Ala Ala Leu Gly Thr Glu Gly Ser Ser Val 
145                 150                 155                 160 


Phe Phe Leu Asp Val Thr Thr Leu Thr Leu Leu Glu Gly Gln Thr Leu 
                165                 170                 175     


Ala Pro Gly Glu Val Leu Arg Ser Val Pro Asp Asp Tyr Arg Cys Gly 
            180                 185                 190         


Lys Ala Leu Gly Pro Val Glu Ser Leu Gln Gly His Leu Arg Asp Pro 
        195                 200                 205             


Thr Lys Ile Leu Ile Gly Tyr Ser Arg Gly Leu Leu Val Ile Trp Asn 
    210                 215                 220                 


Gln Ala Ser Gln Cys Val Asp His Ile Phe Leu Gly Asn Gln Gln Leu 
225                 230                 235                 240 


Glu Ser Leu Cys Trp Gly Arg Asp Ser Ser Thr Val Val Ser Ser His 
                245                 250                 255     


Ser Asp Gly Ser Tyr Ala Val Trp Ser Val Asp Ala Gly Ser Phe Pro 
            260                 265                 270         


Thr Leu Gln Pro Thr Val Ala Thr Thr Pro Tyr Gly Pro Phe Pro Cys 
        275                 280                 285             


Lys Ala Ile Asn Lys Ile Leu Trp Arg Asn Cys Glu Ser Gly Gly His 
    290                 295                 300                 


Phe Ile Ile Phe Ser Gly Gly Met Pro Arg Ala Ser Tyr Gly Asp Arg 
305                 310                 315                 320 


His Cys Val Ser Val Leu Arg Ala Glu Thr Leu Val Thr Leu Asp Phe 
                325                 330                 335     


Thr Ser Arg Ile Ile Asp Phe Phe Thr Val His Ser Thr Arg Pro Glu 
            340                 345                 350         


Asp Glu Phe Asp Asp Pro Gln Ala Leu Ala Val Leu Leu Glu Glu Glu 
        355                 360                 365             


Leu Val Val Leu Asp Leu Gln Thr Pro Gly Trp Pro Ala Val Pro Ala 
    370                 375                 380                 


Pro Tyr Leu Ala Pro Leu His Ser Ser Ala Ile Thr Cys Ser Ala His 
385                 390                 395                 400 


Val Ala Ser Val Pro Ala Lys Leu Trp Ala Arg Ile Val Ser Ala Gly 
                405                 410                 415     


Glu Gln Gln Ser Pro Gln Pro Val Ser Ser Ala Leu Ser Trp Pro Ile 
            420                 425                 430         


Thr Gly Gly Arg Asn Leu Ala Gln Glu Pro Ser Gln Arg Gly Leu Leu 
        435                 440                 445             


Leu Thr Gly His Glu Asp Gly Thr Val Arg Phe Trp Asp Ala Ser Gly 
    450                 455                 460                 


Val Ala Leu Arg Pro Leu Tyr Lys Leu Ser Thr Ala Gly Leu Phe Gln 
465                 470                 475                 480 


Thr Asp Cys Glu His Ala Asp Ser Leu Ala Gln Ala Ala Glu Asp Asp 
                485                 490                 495     


Trp Pro Pro Phe Arg Lys Val Gly Cys Phe Asp Pro Tyr Ser Asp Asp 
            500                 505                 510         


Pro Arg Leu Gly Val Gln Lys Val Ala Leu Cys Lys Tyr Thr Ala Gln 
        515                 520                 525             


Met Val Val Ala Gly Thr Ala Gly Gln Val Leu Val Leu Glu Leu Ser 
    530                 535                 540                 


Asp Val Pro Val Glu Gln Ala Val Ser Val Ala Ile Ile Asp Leu Leu 
545                 550                 555                 560 


Gln Asp Arg Glu Gly Phe Thr Trp Lys Gly His Glu Arg Leu Ser Pro 
                565                 570                 575     


Arg Thr Gly Pro Leu Pro Trp Pro Ala Gly Phe Gln Pro Arg Val Leu 
            580                 585                 590         


Val Gln Cys Leu Pro Pro Ala Ala Val Thr Ala Val Thr Leu His Thr 
        595                 600                 605             


Glu Trp Ser Leu Val Ala Phe Gly Thr Ser His Gly Phe Gly Leu Phe 
    610                 615                 620                 


Asp Tyr Gln Arg Lys Ser Pro Val Leu Ala Arg Cys Thr Leu His Pro 
625                 630                 635                 640 


Asn Asp Ser Leu Ala Met Glu Gly Pro Leu Ser Arg Val Lys Ser Leu 
                645                 650                 655     


Lys Lys Ser Leu Arg Gln Ser Phe Arg Arg Ile Arg Lys Ser Arg Val 
            660                 665                 670         


Ser Gly Lys Lys Arg Ala Ala Asn Ala Ser Ser Lys Leu Gln Glu Ala 
        675                 680                 685             


Asn Ala Gln Leu Ala Glu Gln Ala Cys Pro His Asp Val Glu Met Thr 
    690                 695                 700                 


Pro Val Gln Arg Arg Ile Glu Pro Arg Ser Ala Asp Asp Ser Leu Ser 
705                 710                 715                 720 


Gly Val Val Arg Cys Leu Tyr Phe Ala Asp Thr Phe Leu Arg Asp Gly 
                725                 730                 735     


Ala His His Gly Pro Thr Met Trp Ala Gly Thr Asn Ser Gly Ser Val 
            740                 745                 750         


Phe Ala Tyr Ala Leu Glu Val Pro Ala Ala Ala Val Gly Gly Glu Lys 
        755                 760                 765             


Arg Pro Glu Gln Ala Val Glu Ala Val Leu Gly Lys Glu Val Gln Leu 
    770                 775                 780                 


Met His Arg Ala Pro Val Val Ala Ile Ala Val Leu Asp Gly Arg Gly 
785                 790                 795                 800 


Arg Pro Leu Pro Glu Pro Tyr Glu Ala Ser Arg Asp Leu Ala Gln Ala 
                805                 810                 815     


Pro Asp Met Gln Gly Gly His Ala Val Leu Ile Ala Ser Glu Glu Gln 
            820                 825                 830         


Phe Lys Val Phe Thr Leu Pro Lys Val Ser Ala Lys Thr Lys Phe Lys 
        835                 840                 845             


Leu Thr Ala His Glu Gly Cys Arg Val Arg Lys Val Ala Leu Ala Thr 
    850                 855                 860                 


Phe Ala Ser Val Ala Cys Glu Asp Tyr Ala Glu Thr Cys Leu Ala Cys 
865                 870                 875                 880 


Leu Thr Asn Leu Gly Asp Val His Val Phe Ser Val Pro Gly Leu Arg 
                885                 890                 895     


Pro Gln Val His Tyr Ser Cys Ile Arg Lys Glu Asp Ile Ser Gly Ile 
            900                 905                 910         


Ala Ser Cys Val Phe Thr Arg His Gly Gln Gly Phe Tyr Leu Ile Ser 
        915                 920                 925             


Pro Ser Glu Phe Glu Arg Phe Ser Leu Ser Ala Arg Asn Ile Thr Glu 
    930                 935                 940                 


Pro Leu Cys Ser Leu Asp Ile Asn Trp Pro Arg Asp Ala Thr Gln Ala 
945                 950                 955                 960 


Ser Tyr Arg Ile Arg Glu Ser Pro Lys Leu Ser Gln Ala Asn Gly Thr 
                965                 970                 975     


Pro Ser Ile Leu Leu Ala Pro Gln Ser Leu Asp Gly Ser Pro Asp Pro 
            980                 985                 990         


Ala His Ser Met Gly Pro Asp Thr  Pro Glu Pro Pro Glu  Ala Ala Leu 
        995                 1000                 1005             


Ser Pro  Met Ser Ile Asp Ser  Ala Thr Ser Ala Asp  Thr Thr Leu 
    1010                 1015                 1020             


Asp Thr  Thr Gly Asp Val Thr  Val Glu Asp Val Lys  Asp Phe Leu 
    1025                 1030                 1035             


Gly Ser  Ser Glu Glu Ser Glu  Lys Asn Leu Arg Asn  Leu Ala Glu 
    1040                 1045                 1050             


Asp Glu  Ala His Ala Cys Ala  Ile Leu Ile Lys 
    1055                 1060                 


<210>  6247
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LLGL2__Homo_sapiens__NP_001015002

<400>  6247

Met Arg Arg Phe Leu Arg Pro Gly His Asp Pro Val Arg Glu Arg Leu 
1               5                   10                  15      


Lys Arg Asp Leu Phe Gln Phe Asn Lys Thr Val Glu His Gly Phe Pro 
            20                  25                  30          


His Gln Pro Ser Ala Leu Gly Tyr Ser Pro Ser Leu Arg Ile Leu Ala 
        35                  40                  45              


Ile Gly Thr Arg Ser Gly Ala Ile Lys Leu Tyr Gly Ala Pro Gly Val 
    50                  55                  60                  


Glu Phe Met Gly Leu His Gln Glu Asn Asn Ala Val Thr Gln Ile His 
65                  70                  75                  80  


Leu Leu Pro Gly Gln Cys Gln Leu Val Thr Leu Leu Asp Asp Asn Ser 
                85                  90                  95      


Leu His Leu Trp Ser Leu Lys Val Lys Gly Gly Ala Ser Glu Leu Gln 
            100                 105                 110         


Glu Asp Glu Ser Phe Thr Leu Arg Gly Pro Pro Gly Ala Ala Pro Ser 
        115                 120                 125             


Ala Thr Gln Ile Thr Val Val Leu Pro His Ser Ser Cys Glu Leu Leu 
    130                 135                 140                 


Tyr Leu Gly Thr Glu Ser Gly Asn Val Phe Val Val Gln Leu Pro Ala 
145                 150                 155                 160 


Phe Arg Ala Leu Glu Asp Arg Thr Ile Ser Ser Asp Ala Val Leu Gln 
                165                 170                 175     


Arg Leu Pro Glu Glu Ala Arg His Arg Arg Val Phe Glu Met Val Glu 
            180                 185                 190         


Ala Leu Gln Glu His Pro Arg Asp Pro Asn Gln Ile Leu Ile Gly Tyr 
        195                 200                 205             


Ser Arg Gly Leu Val Val Ile Trp Asp Leu Gln Gly Ser Arg Val Leu 
    210                 215                 220                 


Tyr His Phe Leu Ser Ser Gln Gln Leu Glu Asn Ile Trp Trp Gln Arg 
225                 230                 235                 240 


Asp Gly Arg Leu Leu Val Ser Cys His Ser Asp Gly Ser Tyr Cys Gln 
                245                 250                 255     


Trp Pro Val Ser Ser Glu Ala Gln Gln Pro Glu Pro Leu Arg Ser Leu 
            260                 265                 270         


Val Pro Tyr Gly Pro Phe Pro Cys Lys Ala Ile Thr Arg Ile Leu Trp 
        275                 280                 285             


Leu Thr Thr Arg Gln Gly Leu Pro Phe Thr Ile Phe Gln Gly Gly Met 
    290                 295                 300                 


Pro Arg Ala Ser Tyr Gly Asp Arg His Cys Ile Ser Val Ile His Asp 
305                 310                 315                 320 


Gly Gln Gln Thr Ala Phe Asp Phe Thr Ser Arg Val Ile Gly Phe Thr 
                325                 330                 335     


Val Leu Thr Glu Ala Asp Pro Ala Ala Ser Arg Arg Ala Ser Gly Val 
            340                 345                 350         


Gly Ala Gln Gly 
        355     


<210>  6248
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMAN1__Homo_sapiens__NP_005561

<400>  6248

Met Ala Gly Ser Arg Gln Arg Gly Leu Arg Ala Arg Val Arg Pro Leu 
1               5                   10                  15      


Phe Cys Ala Leu Leu Leu Ser Leu Gly Arg Phe Val Arg Gly Asp Gly 
            20                  25                  30          


Val Gly Gly Asp Pro Ala Val Ala Leu Pro His Arg Arg Phe Glu Tyr 
        35                  40                  45              


Lys Tyr Ser Phe Lys Gly Pro His Leu Val Gln Ser Asp Gly Thr Val 
    50                  55                  60                  


Pro Phe Trp Ala His Ala Gly Asn Ala Ile Pro Ser Ser Asp Gln Ile 
65                  70                  75                  80  


Arg Val Ala Pro Ser Leu Lys Ser Gln Arg Gly Ser Val Trp Thr Lys 
                85                  90                  95      


Thr Lys Ala Ala Phe Glu Asn Trp Glu Val Glu Val Thr Phe Arg Val 
            100                 105                 110         


Thr Gly Arg Gly Arg Ile Gly Ala Asp Gly Leu Ala Ile Trp Tyr Ala 
        115                 120                 125             


Glu Asn Gln Gly Leu Glu Gly Pro Val Phe Gly Ser Ala Asp Leu Trp 
    130                 135                 140                 


Asn Gly Val Gly Ile Phe Phe Asp Ser Phe Asp Asn Asp Gly Lys Lys 
145                 150                 155                 160 


Asn Asn Pro Ala Ile Val Ile Ile Gly Asn Asn Gly Gln Ile His Tyr 
                165                 170                 175     


Asp His Gln Asn Asp Gly Ala Ser Gln Ala Leu Ala Ser Cys Gln Arg 
            180                 185                 190         


Asp Phe Arg Asn Lys Pro Tyr Pro Val Arg Ala Lys Ile Thr Tyr Tyr 
        195                 200                 205             


Gln Asn Thr Leu Thr Val Met Ile Asn Asn Gly Phe Thr Pro Asp Lys 
    210                 215                 220                 


Asn Asp Tyr Glu Phe Cys Ala Lys Val Glu Asn Met Ile Ile Pro Ala 
225                 230                 235                 240 


Gln Gly His Phe Gly Ile Ser Ala Ala Thr Gly Gly Leu Ala Asp Asp 
                245                 250                 255     


His Asp Val Leu Ser Phe Leu Thr Phe Gln Leu Thr Glu Pro Gly Lys 
            260                 265                 270         


Glu Pro Pro Thr Pro Asp Lys Glu Ile Ser Glu Lys Glu Lys Glu Lys 
        275                 280                 285             


Tyr Gln Glu Glu Phe Glu His Phe Gln Gln Glu Leu Asp Lys Lys Lys 
    290                 295                 300                 


Glu Glu Phe Gln Lys Gly His Pro Asp Leu Gln Gly Gln Pro Ala Glu 
305                 310                 315                 320 


Glu Ile Phe Glu Ser Val Gly Asp Arg Glu Leu Arg Gln Val Phe Glu 
                325                 330                 335     


Gly Gln Asn Arg Ile His Leu Glu Ile Lys Gln Leu Asn Arg Gln Leu 
            340                 345                 350         


Asp Met Ile Leu Asp Glu Gln Arg Arg Tyr Val Ser Ser Leu Thr Glu 
        355                 360                 365             


Glu Ile Ser Lys Arg Gly Ala Gly Met Pro Gly Gln His Gly Gln Ile 
    370                 375                 380                 


Thr Gln Gln Glu Leu Asp Thr Val Val Lys Thr Gln His Glu Ile Leu 
385                 390                 395                 400 


Arg Gln Val Asn Glu Met Lys Asn Ser Met Ser Glu Thr Val Arg Leu 
                405                 410                 415     


Val Ser Gly Met Gln His Pro Gly Ser Ala Gly Gly Val Tyr Glu Thr 
            420                 425                 430         


Thr Gln His Phe Ile Asp Ile Lys Glu His Leu His Ile Val Lys Arg 
        435                 440                 445             


Asp Ile Asp Asn Leu Val Gln Arg Asn Met Pro Ser Asn Glu Lys Pro 
    450                 455                 460                 


Lys Cys Pro Glu Leu Pro Pro Phe Pro Ser Cys Leu Ser Thr Val His 
465                 470                 475                 480 


Phe Ile Ile Phe Val Val Val Gln Thr Val Leu Phe Ile Gly Tyr Ile 
                485                 490                 495     


Met Tyr Arg Ser Gln Gln Glu Ala Ala Ala Lys Lys Phe Phe 
            500                 505                 510 


<210>  6249
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMAN1L__Homo_sapiens__NP_068591

<400>  6249

Met Pro Ala Val Ser Gly Pro Gly Pro Leu Phe Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Asp Pro His Ser Pro Glu Thr Gly Cys Pro Pro Leu Arg Arg 
            20                  25                  30          


Phe Glu Tyr Lys Leu Ser Phe Lys Gly Pro Arg Leu Ala Leu Pro Gly 
        35                  40                  45              


Ala Gly Ile Pro Phe Trp Ser His His Gly Asp Ala Ile Leu Gly Leu 
    50                  55                  60                  


Glu Glu Val Arg Leu Thr Pro Ser Met Arg Asn Arg Ser Gly Ala Val 
65                  70                  75                  80  


Trp Ser Arg Ala Ser Val Pro Phe Ser Ala Trp Glu Val Glu Val Gln 
                85                  90                  95      


Met Arg Val Thr Gly Leu Gly Arg Arg Gly Ala Gln Gly Met Ala Val 
            100                 105                 110         


Trp Tyr Thr Arg Gly Arg Gly His Val Gly Ser Val Leu Gly Gly Leu 
        115                 120                 125             


Ala Ser Trp Asp Gly Ile Gly Ile Phe Phe Asp Ser Pro Ala Glu Asp 
    130                 135                 140                 


Thr Gln Asp Ser Pro Ala Ile Arg Val Leu Ala Ser Asp Gly His Ile 
145                 150                 155                 160 


Pro Ser Glu Gln Pro Gly Asp Gly Ala Ser Gln Gly Leu Gly Ser Cys 
                165                 170                 175     


His Trp Asp Phe Arg Asn Arg Pro His Pro Phe Arg Ala Arg Ile Thr 
            180                 185                 190         


Tyr Trp Gly Gln Arg Leu Arg Met Ser Leu Asn Ser Gly Leu Thr Pro 
        195                 200                 205             


Ser Asp Pro Gly Glu Phe Cys Val Asp Val Gly Pro Leu Leu Leu Val 
    210                 215                 220                 


Pro Gly Gly Phe Phe Gly Val Ser Ala Ala Thr Gly Thr Leu Ala Asp 
225                 230                 235                 240 


Asp His Asp Val Leu Ser Phe Leu Thr Phe Ser Leu Ser Glu Pro Ser 
                245                 250                 255     


Pro Glu Val Pro Pro Gln Pro Phe Leu Glu Met Gln Gln Leu Arg Leu 
            260                 265                 270         


Ala Arg Gln Leu Glu Gly Leu Trp Ala Arg Leu Gly Leu Gly Thr Arg 
        275                 280                 285             


Glu Asp Val Thr Pro Lys Ser Asp Ser Glu Ala Gln Gly Glu Gly Glu 
    290                 295                 300                 


Arg Leu Phe Asp Leu Glu Glu Thr Leu Gly Arg His Arg Arg Ile Leu 
305                 310                 315                 320 


Gln Ala Leu Arg Gly Leu Ser Lys Gln Leu Ala Gln Ala Glu Arg Gln 
                325                 330                 335     


Trp Lys Lys Gln Leu Gly Pro Pro Gly Gln Ala Arg Pro Asp Gly Gly 
            340                 345                 350         


Trp Ala Leu Asp Ala Ser Cys Gln Ile Pro Ser Thr Pro Gly Arg Gly 
        355                 360                 365             


Gly His Leu Ser Met Ser Leu Asn Lys Asp Ser Ala Lys Val Gly Ala 
    370                 375                 380                 


Leu Leu His Gly Gln Trp Thr Leu Leu Gln Ala Leu Gln Glu Met Arg 
385                 390                 395                 400 


Asp Ala Ala Val Arg Met Ala Ala Glu Ala Gln Val Ser Tyr Leu Pro 
                405                 410                 415     


Val Gly Ile Glu His His Phe Leu Glu Leu Asp His Ile Leu Gly Leu 
            420                 425                 430         


Leu Gln Glu Glu Leu Arg Gly Pro Ala Lys Ala Ala Ala Lys Ala Pro 
        435                 440                 445             


Arg Pro Pro Gly Gln Pro Pro Arg Ala Ser Ser Cys Leu Gln Pro Gly 
    450                 455                 460                 


Ile Phe Leu Phe Tyr Leu Leu Ile Gln Thr Val Gly Phe Phe Gly Tyr 
465                 470                 475                 480 


Val His Phe Arg Gln Glu Leu Asn Lys Ser Leu Gln Glu Cys Leu Ser 
                485                 490                 495     


Thr Gly Ser Leu Pro Leu Gly Pro Ala Pro His Thr Pro Arg Ala Leu 
            500                 505                 510         


Gly Ile Leu Arg Arg Gln Pro Leu Pro Ala Ser Met Pro Ala 
        515                 520                 525     


<210>  6250
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMAN2L__Homo_sapiens__NP_001135764

<400>  6250

Met Ala Ala Thr Leu Gly Pro Leu Gly Ser Trp Gln Gln Trp Arg Arg 
1               5                   10                  15      


Cys Leu Ser Ala Arg Asp Gly Ser Arg Met Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Gly Ser Gly Gln Gly Pro Gln Gln Val Gly Ala Gly Gln Thr Phe 
        35                  40                  45              


Glu Tyr Leu Lys Arg Glu His Ser Leu Ser Lys Pro Tyr Gln Gly Val 
    50                  55                  60                  


Gly Thr Gly Ser Ser Ser Leu Trp Asn Leu Met Gly Asn Ala Met Val 
65                  70                  75                  80  


Met Thr Gln Tyr Ile Arg Leu Thr Pro Asp Met Gln Ser Lys Gln Gly 
                85                  90                  95      


Ala Leu Trp Asn Arg Val Pro Cys Phe Leu Arg Asp Trp Glu Leu Gln 
            100                 105                 110         


Val His Phe Lys Ile His Gly Gln Gly Lys Lys Asn Leu His Gly Asp 
        115                 120                 125             


Gly Leu Ala Ile Trp Tyr Thr Lys Asp Arg Met Gln Pro Gly Pro Val 
    130                 135                 140                 


Phe Gly Asn Met Asp Lys Phe Val Gly Leu Gly Val Phe Val Asp Thr 
145                 150                 155                 160 


Tyr Pro Asn Glu Glu Lys Gln Gln Glu Ala Gln Lys Arg Arg Tyr Ser 
                165                 170                 175     


Pro Gly Val Gln Arg Val Phe Pro Tyr Ile Ser Ala Met Val Asn Asn 
            180                 185                 190         


Gly Ser Leu Ser Tyr Asp His Glu Arg Asp Gly Arg Pro Thr Glu Leu 
        195                 200                 205             


Gly Gly Cys Thr Ala Ile Val Arg Asn Leu His Tyr Asp Thr Phe Leu 
    210                 215                 220                 


Val Ile Arg Tyr Val Lys Arg His Leu Thr Ile Met Met Asp Ile Asp 
225                 230                 235                 240 


Gly Lys His Glu Trp Arg Asp Cys Ile Glu Val Pro Gly Val Arg Leu 
                245                 250                 255     


Pro Arg Gly Tyr Tyr Phe Gly Thr Ser Ser Ile Thr Gly Asp Leu Ser 
            260                 265                 270         


Asp Asn His Asp Val Ile Ser Leu Lys Leu Phe Glu Leu Thr Val Glu 
        275                 280                 285             


Arg Thr Pro Glu Glu Glu Lys Leu His Arg Asp Val Phe Leu Pro Ser 
    290                 295                 300                 


Val Asp Asn Met Lys Leu Pro Glu Met Thr Ala Pro Leu Pro Pro Leu 
305                 310                 315                 320 


Ser Gly Leu Ala Leu Phe Leu Ile Val Phe Phe Ser Leu Val Phe Ser 
                325                 330                 335     


Val Phe Ala Ile Val Ile Gly Ile Ile Leu Tyr Asn Lys Trp Gln Glu 
            340                 345                 350         


Gln Ser Arg Lys Arg Phe Tyr 
        355                 


<210>  6251
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMBR1__Homo_sapiens__NP_071903

<400>  6251

Met Glu Gly Gln Asp Glu Val Ser Ala Arg Glu Gln His Phe His Ser 
1               5                   10                  15      


Gln Val Arg Glu Ser Thr Ile Cys Phe Leu Leu Phe Ala Ile Leu Tyr 
            20                  25                  30          


Val Val Ser Tyr Phe Ile Ile Thr Arg Tyr Lys Arg Lys Ser Asp Glu 
        35                  40                  45              


Gln Glu Asp Glu Asp Ala Ile Val Asn Arg Ile Ser Leu Phe Leu Ser 
    50                  55                  60                  


Thr Phe Thr Leu Ala Val Ser Ala Gly Ala Val Leu Leu Leu Pro Phe 
65                  70                  75                  80  


Ser Ile Ile Ser Asn Glu Ile Leu Leu Ser Phe Pro Gln Asn Tyr Tyr 
                85                  90                  95      


Ile Gln Trp Leu Asn Gly Ser Leu Ile His Gly Leu Trp Asn Leu Ala 
            100                 105                 110         


Ser Leu Phe Ser Asn Leu Cys Leu Phe Val Leu Met Pro Phe Ala Phe 
        115                 120                 125             


Phe Phe Leu Glu Ser Glu Gly Phe Ala Gly Leu Lys Lys Gly Ile Arg 
    130                 135                 140                 


Ala Arg Ile Leu Glu Thr Leu Val Met Leu Leu Leu Leu Ala Leu Leu 
145                 150                 155                 160 


Ile Leu Gly Ile Val Trp Val Ala Ser Ala Leu Ile Asp Asn Asp Ala 
                165                 170                 175     


Ala Ser Met Glu Ser Leu Tyr Asp Leu Trp Glu Phe Tyr Leu Pro Tyr 
            180                 185                 190         


Leu Tyr Ser Cys Ile Ser Leu Met Gly Cys Leu Leu Leu Leu Leu Cys 
        195                 200                 205             


Thr Pro Val Gly Leu Ser Arg Met Phe Thr Val Met Gly Gln Leu Leu 
    210                 215                 220                 


Val Lys Pro Thr Ile Leu Glu Asp Leu Asp Glu Gln Ile Tyr Ile Ile 
225                 230                 235                 240 


Thr Leu Glu Glu Glu Ala Leu Gln Arg Arg Leu Asn Gly Leu Ser Ser 
                245                 250                 255     


Ser Val Glu Tyr Asn Ile Met Glu Leu Glu Gln Glu Leu Glu Asn Val 
            260                 265                 270         


Lys Thr Leu Lys Thr Lys Leu Glu Arg Arg Lys Lys Ala Ser Ala Trp 
        275                 280                 285             


Glu Arg Asn Leu Val Tyr Pro Ala Val Met Val Leu Leu Leu Ile Glu 
    290                 295                 300                 


Thr Ser Ile Ser Val Leu Leu Val Ala Cys Asn Ile Leu Cys Leu Leu 
305                 310                 315                 320 


Val Asp Glu Thr Ala Met Pro Lys Gly Thr Arg Gly Pro Gly Ile Gly 
                325                 330                 335     


Asn Ala Ser Leu Ser Thr Phe Gly Phe Val Gly Ala Ala Leu Glu Ile 
            340                 345                 350         


Ile Leu Ile Phe Tyr Leu Met Val Ser Ser Val Val Gly Phe Tyr Ser 
        355                 360                 365             


Leu Arg Phe Phe Gly Asn Phe Thr Pro Lys Lys Asp Asp Thr Thr Met 
    370                 375                 380                 


Thr Lys Ile Ile Gly Asn Cys Val Ser Ile Leu Val Leu Ser Ser Ala 
385                 390                 395                 400 


Leu Pro Val Met Ser Arg Thr Leu Gly Ile Thr Arg Phe Asp Leu Leu 
                405                 410                 415     


Gly Asp Phe Gly Arg Phe Asn Trp Leu Gly Asn Phe Tyr Ile Val Leu 
            420                 425                 430         


Ser Tyr Asn Leu Leu Phe Ala Ile Val Thr Thr Leu Cys Leu Val Arg 
        435                 440                 445             


Lys Phe Thr Ser Ala Val Arg Glu Glu Leu Phe Lys Ala Leu Gly Leu 
    450                 455                 460                 


His Lys Leu His Leu Pro Asn Thr Ser Arg Asp Ser Glu Thr Ala Lys 
465                 470                 475                 480 


Pro Ser Val Asn Gly His Gln Lys Ala Leu 
                485                 490 


<210>  6252
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMBRD1__Homo_sapiens__NP_060838

<400>  6252

Met Ala Thr Ser Gly Ala Ala Ser Ala Glu Leu Val Ile Gly Trp Cys 
1               5                   10                  15      


Ile Phe Gly Leu Leu Leu Leu Ala Ile Leu Ala Phe Cys Trp Ile Tyr 
            20                  25                  30          


Val Arg Lys Tyr Gln Ser Arg Arg Glu Ser Glu Val Val Ser Thr Ile 
        35                  40                  45              


Thr Ala Ile Phe Ser Leu Ala Ile Ala Leu Ile Thr Ser Ala Leu Leu 
    50                  55                  60                  


Pro Val Asp Ile Phe Leu Val Ser Tyr Met Lys Asn Gln Asn Gly Thr 
65                  70                  75                  80  


Phe Lys Asp Trp Ala Asn Ala Asn Val Ser Arg Gln Ile Glu Asp Thr 
                85                  90                  95      


Val Leu Tyr Gly Tyr Tyr Thr Leu Tyr Ser Val Ile Leu Phe Cys Val 
            100                 105                 110         


Phe Phe Trp Ile Pro Phe Val Tyr Phe Tyr Tyr Glu Glu Lys Asp Asp 
        115                 120                 125             


Asp Asp Thr Ser Lys Cys Thr Gln Ile Lys Thr Ala Leu Lys Tyr Thr 
    130                 135                 140                 


Leu Gly Phe Val Val Ile Cys Ala Leu Leu Leu Leu Val Gly Ala Phe 
145                 150                 155                 160 


Val Pro Leu Asn Val Pro Asn Asn Lys Asn Ser Thr Glu Trp Glu Lys 
                165                 170                 175     


Val Lys Ser Leu Phe Glu Glu Leu Gly Ser Ser His Gly Leu Ala Ala 
            180                 185                 190         


Leu Ser Phe Ser Ile Ser Ser Leu Thr Leu Ile Gly Met Leu Ala Ala 
        195                 200                 205             


Ile Thr Tyr Thr Ala Tyr Gly Met Ser Ala Leu Pro Leu Asn Leu Ile 
    210                 215                 220                 


Lys Gly Thr Arg Ser Ala Ala Tyr Glu Arg Leu Glu Asn Thr Glu Asp 
225                 230                 235                 240 


Ile Glu Glu Val Glu Gln His Ile Gln Thr Ile Lys Ser Lys Ser Lys 
                245                 250                 255     


Asp Gly Arg Pro Leu Pro Ala Arg Asp Lys Arg Ala Leu Lys Gln Phe 
            260                 265                 270         


Glu Glu Arg Leu Arg Thr Leu Lys Lys Arg Glu Arg His Leu Glu Phe 
        275                 280                 285             


Ile Glu Asn Ser Trp Trp Thr Lys Phe Cys Gly Ala Leu Arg Pro Leu 
    290                 295                 300                 


Lys Ile Val Trp Gly Ile Phe Phe Ile Leu Val Ala Leu Leu Phe Val 
305                 310                 315                 320 


Ile Ser Leu Phe Leu Ser Asn Leu Asp Lys Ala Leu His Ser Ala Gly 
                325                 330                 335     


Ile Asp Ser Gly Phe Ile Ile Phe Gly Ala Asn Leu Ser Asn Pro Leu 
            340                 345                 350         


Asn Met Leu Leu Pro Leu Leu Gln Thr Val Phe Pro Leu Asp Tyr Ile 
        355                 360                 365             


Leu Ile Thr Ile Ile Ile Met Tyr Phe Ile Phe Thr Ser Met Ala Gly 
    370                 375                 380                 


Ile Arg Asn Ile Gly Ile Trp Phe Phe Trp Ile Arg Leu Tyr Lys Ile 
385                 390                 395                 400 


Arg Arg Gly Arg Thr Arg Pro Gln Ala Leu Leu Phe Leu Cys Met Ile 
                405                 410                 415     


Leu Leu Leu Ile Val Leu His Thr Ser Tyr Met Ile Tyr Ser Leu Ala 
            420                 425                 430         


Pro Gln Tyr Val Met Tyr Gly Ser Gln Asn Tyr Leu Ile Glu Thr Asn 
        435                 440                 445             


Ile Thr Ser Asp Asn His Lys Gly Asn Ser Thr Leu Ser Val Pro Lys 
    450                 455                 460                 


Arg Cys Asp Ala Asp Ala Pro Glu Asp Gln Cys Thr Val Thr Arg Thr 
465                 470                 475                 480 


Tyr Leu Phe Leu His Lys Phe Trp Phe Phe Ser Ala Ala Tyr Tyr Phe 
                485                 490                 495     


Gly Asn Trp Ala Phe Leu Gly Val Phe Leu Ile Gly Leu Ile Val Ser 
            500                 505                 510         


Cys Cys Lys Gly Lys Lys Ser Val Ile Glu Gly Val Asp Glu Asp Ser 
        515                 520                 525             


Asp Ile Ser Asp Asp Glu Pro Ser Val Tyr Ser Ala 
    530                 535                 540 


<210>  6253
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMBRD2__Homo_sapiens__NP_001007528

<400>  6253

Met Ser Gly Ala Ala Leu Gly Leu Glu Ile Val Phe Val Phe Phe Leu 
1               5                   10                  15      


Ala Leu Phe Leu Leu His Arg Tyr Gly Asp Phe Lys Lys Gln His Arg 
            20                  25                  30          


Leu Val Ile Ile Gly Thr Leu Leu Ala Trp Tyr Leu Cys Phe Leu Ile 
        35                  40                  45              


Val Phe Ile Leu Pro Leu Asp Val Ser Thr Thr Ile Tyr Asn Arg Cys 
    50                  55                  60                  


Lys His Ala Ala Ala Asn Ser Ser Pro Pro Glu Asn Ser Asn Ile Thr 
65                  70                  75                  80  


Gly Leu Tyr Ala Thr Ala Asn Pro Val Pro Ser Gln His Pro Cys Phe 
                85                  90                  95      


Lys Pro Trp Ser Tyr Ile Pro Asp Gly Ile Met Pro Ile Phe Trp Arg 
            100                 105                 110         


Val Val Tyr Trp Thr Ser Gln Phe Leu Thr Trp Ile Leu Leu Pro Phe 
        115                 120                 125             


Met Gln Ser Tyr Ala Arg Ser Gly Gly Phe Ser Ile Thr Gly Lys Ile 
    130                 135                 140                 


Lys Thr Ala Leu Ile Glu Asn Ala Ile Tyr Tyr Gly Thr Tyr Leu Leu 
145                 150                 155                 160 


Ile Phe Gly Ala Phe Leu Ile Tyr Val Ala Val Asn Pro His Leu His 
                165                 170                 175     


Leu Glu Trp Asn Gln Leu Gln Thr Ile Gly Ile Ala Ala Ala Asn Thr 
            180                 185                 190         


Trp Gly Leu Phe Leu Leu Val Leu Leu Leu Gly Tyr Gly Leu Val Glu 
        195                 200                 205             


Ile Pro Arg Ser Tyr Trp Asn Gly Ala Lys Arg Gly Tyr Leu Leu Met 
    210                 215                 220                 


Lys Thr Tyr Phe Lys Ala Ala Lys Leu Met Thr Glu Lys Ala Asp Ala 
225                 230                 235                 240 


Glu Glu Asn Leu Glu Asp Ala Met Glu Glu Val Arg Lys Val Asn Glu 
                245                 250                 255     


Ser Ile Lys Tyr Asn His Pro Leu Arg Lys Cys Val Asp Thr Ile Leu 
            260                 265                 270         


Lys Lys Cys Pro Thr Glu Tyr Gln Glu Lys Met Gly Arg Asn Met Asp 
        275                 280                 285             


Asp Tyr Glu Asp Phe Asp Glu Lys His Ser Ile Tyr Pro Ser Glu Lys 
    290                 295                 300                 


Ser Leu Val Lys Leu His Lys Gln Val Ile Tyr Ser Val Gln Arg His 
305                 310                 315                 320 


Arg Arg Thr Gln Val Gln Trp Gln Ile Leu Leu Glu Gln Ala Phe Tyr 
                325                 330                 335     


Leu Glu Asp Val Ala Lys Asn Glu Thr Ser Ala Thr His Gln Phe Val 
            340                 345                 350         


His Thr Phe Gln Ser Pro Glu Pro Glu Asn Arg Phe Ile Gln Tyr Phe 
        355                 360                 365             


Tyr Asn Pro Thr Phe Glu Trp Tyr Trp Glu Cys Leu Leu Arg Pro Trp 
    370                 375                 380                 


Phe Tyr Lys Ile Leu Ala Val Val Leu Ser Ile Phe Ser Val Ile Val 
385                 390                 395                 400 


Val Trp Ser Glu Cys Thr Phe Phe Ser Thr Thr Pro Val Leu Ser Leu 
                405                 410                 415     


Phe Ala Val Phe Ile Gln Leu Ala Glu Lys Thr Tyr Asn Tyr Ile Tyr 
            420                 425                 430         


Ile Glu Ile Ala Cys Phe Leu Ser Ile Phe Phe Leu Ser Ile Cys Val 
        435                 440                 445             


Tyr Ser Thr Val Phe Arg Ile Arg Val Phe Asn Tyr Tyr Tyr Leu Ala 
    450                 455                 460                 


Ser His His Gln Thr Asp Ala Tyr Ser Leu Leu Phe Ser Gly Met Leu 
465                 470                 475                 480 


Phe Cys Arg Leu Thr Pro Pro Leu Cys Leu Asn Phe Leu Gly Leu Thr 
                485                 490                 495     


His Met Asp Ser Ser Ile Ser His Lys Asn Thr Gln Pro Thr Ala Tyr 
            500                 505                 510         


Thr Ser Ile Met Gly Ser Met Lys Val Leu Ser Phe Ile Ala Asp Gly 
        515                 520                 525             


Phe Tyr Ile Tyr Tyr Pro Met Leu Val Val Ile Leu Cys Ile Ala Thr 
    530                 535                 540                 


Tyr Phe Ser Leu Gly Thr Arg Cys Leu Asn Leu Leu Gly Phe Gln Gln 
545                 550                 555                 560 


Phe Met Gly Asp Asp Asp Met Thr Ser Asp Leu Val Asn Glu Gly Lys 
                565                 570                 575     


Glu Leu Ile Arg Lys Glu Lys Arg Lys Arg Gln Arg Gln Glu Glu Gly 
            580                 585                 590         


Glu Asn Arg Arg Arg Glu Trp Lys Glu Arg Tyr Gly His Asn Arg Glu 
        595                 600                 605             


Asp Ser Thr Arg Asn Arg Asn Ile His Thr Asp Pro Lys Glu Ser Asn 
    610                 615                 620                 


Phe Ser Asp Val Asn Thr Asn Arg Ser Ala Phe Lys Tyr Thr Arg Ala 
625                 630                 635                 640 


Asn Asn Arg Thr Glu Arg Asp Arg Ile Glu Leu Leu Gln Asp Ala Glu 
                645                 650                 655     


Pro Leu Asp Phe Asn Ala Glu Thr Phe Thr Asp Asp Pro Leu Glu Ser 
            660                 665                 670         


Glu Ser Gly Arg Tyr Gln Pro Gly Gly Arg Tyr Leu Ser Met Ser Arg 
        675                 680                 685             


Ser Asp Ile Phe Asn Asp Val 
    690                 695 


<210>  6254
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMCD1__Homo_sapiens__NP_001265162

<400>  6254

Met Asp Ser Lys Tyr Ser Thr Leu Thr Ala Arg Val Lys Gly Gly Asp 
1               5                   10                  15      


Gly Ile Arg Ile Tyr Lys Arg Asn Arg Met Ile Met Thr Asn Pro Ile 
            20                  25                  30          


Ala Thr Gly Lys Asp Pro Thr Phe Asp Thr Ile Thr Tyr Glu Trp Ala 
        35                  40                  45              


Pro Pro Gly Val Thr Gln Lys Leu Gly Leu Gln Tyr Met Glu Leu Ile 
    50                  55                  60                  


Pro Lys Glu Lys Gln Pro Val Thr Gly Thr Glu Gly Ala Phe Tyr Arg 
65                  70                  75                  80  


Arg Arg Gln Leu Met His Gln Leu Pro Ile Tyr Asp Gln Asp Pro Ser 
                85                  90                  95      


Arg Cys Arg Gly Leu Leu Glu Asn Glu Leu Lys Leu Met Glu Glu Phe 
            100                 105                 110         


Val Lys Gln Tyr Lys Ser Glu Ala Leu Gly Val Gly Glu Val Ala Leu 
        115                 120                 125             


Pro Gly Gln Gly Gly Leu Pro Lys Glu Glu Gly Lys Gln Gln Glu Lys 
    130                 135                 140                 


Pro Glu Gly Ala Glu Thr Thr Ala Ala Thr Thr Asn Gly Ser Leu Ser 
145                 150                 155                 160 


Asp Pro Ser Lys Glu Val Glu Tyr Val Cys Glu Leu Cys Lys Gly Ala 
                165                 170                 175     


Ala Pro Pro Asp Ser Pro Val Val Tyr Ser Asp Arg Ala Gly Tyr Asn 
            180                 185                 190         


Lys Gln Trp His Pro Thr Cys Phe Val Cys Ala Lys Cys Ser Glu Pro 
        195                 200                 205             


Leu Val Asp Leu Ile Tyr Phe Trp Lys Asp Gly Ala Pro Trp Cys Gly 
    210                 215                 220                 


Arg His Tyr Cys Glu Ser Leu Arg Pro Arg Cys Ser Gly Cys Asp Glu 
225                 230                 235                 240 


Ile Ile Phe Ala Glu Asp Tyr Gln Arg Val Glu Asp Leu Ala Trp His 
                245                 250                 255     


Arg Lys His Phe Val Cys Glu Gly Cys Glu Gln Leu Leu Ser Gly Arg 
            260                 265                 270         


Ala Tyr Ile Val Thr Lys Gly Gln Leu Leu Cys Pro Thr Cys Ser Lys 
        275                 280                 285             


Ser Lys Arg Ser 
    290         


<210>  6255
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMF1__Homo_sapiens__NP_073610

<400>  6255

Met Arg Pro Asp Ser Pro Thr Met Ala Ala Pro Ala Glu Ser Leu Arg 
1               5                   10                  15      


Arg Arg Lys Thr Gly Tyr Ser Asp Pro Glu Pro Glu Ser Pro Pro Ala 
            20                  25                  30          


Pro Gly Arg Gly Pro Ala Gly Ser Pro Ala His Leu His Thr Gly Thr 
        35                  40                  45              


Phe Trp Leu Thr Arg Ile Val Leu Leu Lys Ala Leu Ala Phe Val Tyr 
    50                  55                  60                  


Phe Val Ala Phe Leu Val Ala Phe His Gln Asn Lys Gln Leu Ile Gly 
65                  70                  75                  80  


Asp Arg Gly Leu Leu Pro Cys Arg Val Phe Leu Lys Asn Phe Gln Gln 
                85                  90                  95      


Tyr Phe Gln Asp Arg Thr Ser Trp Glu Val Phe Ser Tyr Met Pro Thr 
            100                 105                 110         


Ile Leu Trp Leu Met Asp Trp Ser Asp Met Asn Ser Asn Leu Asp Leu 
        115                 120                 125             


Leu Ala Leu Leu Gly Leu Gly Ile Ser Ser Phe Val Leu Ile Thr Gly 
    130                 135                 140                 


Cys Ala Asn Met Leu Leu Met Ala Ala Leu Trp Gly Leu Tyr Met Ser 
145                 150                 155                 160 


Leu Val Asn Val Gly His Val Trp Tyr Ser Phe Gly Trp Glu Ser Gln 
                165                 170                 175     


Leu Leu Glu Thr Gly Phe Leu Gly Ile Phe Leu Cys Pro Leu Trp Thr 
            180                 185                 190         


Leu Ser Arg Leu Pro Gln His Thr Pro Thr Ser Arg Ile Val Leu Trp 
        195                 200                 205             


Gly Phe Arg Trp Leu Ile Phe Arg Ile Met Leu Gly Ala Gly Leu Ile 
    210                 215                 220                 


Lys Ile Arg Gly Asp Arg Cys Trp Arg Asp Leu Thr Cys Met Asp Phe 
225                 230                 235                 240 


His Tyr Glu Thr Gln Pro Met Pro Asn Pro Val Ala Tyr Tyr Leu His 
                245                 250                 255     


His Ser Pro Trp Trp Phe His Arg Phe Glu Thr Leu Ser Asn His Phe 
            260                 265                 270         


Ile Glu Leu Leu Val Pro Phe Phe Leu Phe Leu Gly Arg Arg Ala Cys 
        275                 280                 285             


Ile Ile His Gly Val Leu Gln Ile Leu Phe Gln Ala Val Leu Ile Val 
    290                 295                 300                 


Ser Gly Asn Leu Ser Phe Leu Asn Trp Leu Thr Met Val Pro Ser Leu 
305                 310                 315                 320 


Ala Cys Phe Asp Asp Ala Thr Leu Gly Phe Leu Phe Pro Ser Gly Pro 
                325                 330                 335     


Gly Ser Leu Lys Asp Arg Val Leu Gln Met Gln Arg Asp Ile Arg Gly 
            340                 345                 350         


Ala Arg Pro Glu Pro Arg Phe Gly Ser Val Val Arg Arg Ala Ala Asn 
        355                 360                 365             


Val Ser Leu Gly Val Leu Leu Ala Trp Leu Ser Val Pro Val Val Leu 
    370                 375                 380                 


Asn Leu Leu Ser Ser Arg Gln Val Met Asn Thr His Phe Asn Ser Leu 
385                 390                 395                 400 


His Ile Val Asn Thr Tyr Gly Ala Phe Gly Ser Ile Thr Lys Glu Arg 
                405                 410                 415     


Ala Glu Val Ile Leu Gln Gly Thr Ala Ser Ser Asn Ala Ser Ala Pro 
            420                 425                 430         


Asp Ala Met Trp Glu Asp Tyr Glu Phe Lys Cys Lys Pro Gly Asp Pro 
        435                 440                 445             


Ser Arg Arg Pro Cys Leu Ile Ser Pro Tyr His Tyr Arg Leu Asp Trp 
    450                 455                 460                 


Leu Met Trp Phe Ala Ala Phe Gln Thr Tyr Glu His Asn Asp Trp Ile 
465                 470                 475                 480 


Ile His Leu Ala Gly Lys Leu Leu Ala Ser Asp Ala Glu Ala Leu Ser 
                485                 490                 495     


Leu Leu Ala His Asn Pro Phe Ala Gly Arg Pro Pro Pro Arg Trp Val 
            500                 505                 510         


Arg Gly Glu His Tyr Arg Tyr Lys Phe Ser Arg Pro Gly Gly Arg His 
        515                 520                 525             


Ala Ala Glu Gly Lys Trp Trp Val Arg Lys Arg Ile Gly Ala Tyr Phe 
    530                 535                 540                 


Pro Pro Leu Ser Leu Glu Glu Leu Arg Pro Tyr Phe Arg Asp Arg Gly 
545                 550                 555                 560 


Trp Pro Leu Pro Gly Pro Leu 
                565         


<210>  6256
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMLN__Homo_sapiens__NP_001129521

<400>  6256

Met Val Thr Thr Leu Gly Pro Lys Met Ala Ala Glu Trp Gly Gly Gly 
1               5                   10                  15      


Val Gly Tyr Ser Gly Ser Gly Pro Gly Arg Ser Arg Trp Arg Trp Ser 
            20                  25                  30          


Gly Ser Val Trp Val Arg Ser Val Leu Leu Leu Leu Gly Gly Leu Arg 
        35                  40                  45              


Ala Ser Ala Thr Ser Thr Pro Val Ser Leu Gly Ser Ser Pro Pro Cys 
    50                  55                  60                  


Arg His His Val Pro Ser Asp Thr Glu Val Ile Asn Lys Val His Leu 
65                  70                  75                  80  


Lys Ala Asn His Val Val Lys Arg Asp Val Asp Glu His Leu Arg Ile 
                85                  90                  95      


Lys Thr Val Tyr Asp Lys Ser Val Glu Glu Leu Leu Pro Glu Lys Lys 
            100                 105                 110         


Asn Leu Val Lys Asn Lys Leu Phe Pro Gln Ala Ile Ser Tyr Leu Glu 
        115                 120                 125             


Lys Thr Phe Gln Val Arg Arg Pro Ala Gly Thr Ile Leu Leu Ser Arg 
    130                 135                 140                 


Gln Cys Ala Thr Asn Gln Tyr Leu Arg Lys Glu Asn Asp Pro His Arg 
145                 150                 155                 160 


Tyr Cys Thr Gly Glu Cys Ala Ala His Thr Lys Cys Gly Pro Val Ile 
                165                 170                 175     


Val Pro Glu Glu His Leu Gln Gln Cys Arg Val Tyr Arg Gly Gly Lys 
            180                 185                 190         


Trp Pro His Gly Ala Val Gly Val Pro Asp Gln Glu Gly Ile Ser Asp 
        195                 200                 205             


Ala Asp Phe Val Leu Tyr Val Gly Ala Leu Ala Thr Glu Arg Cys Ser 
    210                 215                 220                 


His Glu Asn Ile Ile Ser Tyr Ala Ala Tyr Cys Gln Gln Glu Ala Asn 
225                 230                 235                 240 


Met Asp Arg Pro Ile Ala Gly Tyr Ala Asn Leu Cys Pro Asn Met Ile 
                245                 250                 255     


Ser Thr Gln Pro Gln Glu Phe Val Gly Met Leu Ser Thr Val Lys His 
            260                 265                 270         


Glu Val Ile His Ala Leu Gly Phe Ser Ala Gly Leu Phe Ala Phe Tyr 
        275                 280                 285             


His Asp Lys Asp Gly Asn Pro Leu Thr Ser Arg Phe Ala Asp Gly Leu 
    290                 295                 300                 


Pro Pro Phe Asn Tyr Ser Leu Gly Leu Tyr Gln Trp Ser Asp Lys Val 
305                 310                 315                 320 


Val Arg Lys Val Glu Arg Leu Trp Asp Val Arg Asp Asn Lys Ile Val 
                325                 330                 335     


Arg His Thr Val Tyr Leu Leu Val Thr Pro Arg Val Val Glu Glu Ala 
            340                 345                 350         


Arg Lys His Phe Asp Cys Pro Val Leu Glu Gly Met Glu Leu Glu Asn 
        355                 360                 365             


Gln Gly Gly Val Gly Thr Glu Leu Asn His Trp Glu Lys Arg Leu Leu 
    370                 375                 380                 


Glu Asn Glu Ala Met Thr Gly Ser His Thr Gln Asn Arg Val Leu Ser 
385                 390                 395                 400 


Arg Ile Thr Leu Ala Leu Met Glu Asp Thr Gly Trp Tyr Lys Ala Asn 
                405                 410                 415     


Tyr Ser Met Ala Glu Lys Leu Asp Trp Gly Arg Gly Met Gly Cys Asp 
            420                 425                 430         


Phe Val Arg Lys Ser Cys Lys Phe Trp Ile Asp Gln Gln Arg Gln Lys 
        435                 440                 445             


Arg Gln Met Leu Ser Pro Tyr Cys Asp Thr Leu Arg Ser Asn Pro Leu 
    450                 455                 460                 


Gln Leu Thr Cys Arg Gln Asp Gln Arg Ala Val Ala Val Cys Asn Leu 
465                 470                 475                 480 


Gln Lys Phe Pro Lys Pro Leu Pro Gln Glu Tyr Gln Tyr Phe Asp Glu 
                485                 490                 495     


Leu Ser Gly Ile Pro Ala Glu Asp Leu Pro Tyr Tyr Gly Gly Ser Val 
            500                 505                 510         


Glu Ile Ala Asp Tyr Cys Pro Phe Ser Gln Glu Phe Ser Trp His Leu 
        515                 520                 525             


Ser Gly Glu Tyr Gln Arg Ser Ser Asp Cys Arg Ile Leu Glu Asn Gln 
    530                 535                 540                 


Pro Glu Ile Phe Lys Asn Tyr Gly Ala Glu Lys Tyr Gly Pro His Ser 
545                 550                 555                 560 


Val Cys Leu Ile Gln Lys Ser Ala Phe Val Met Glu Lys Cys Glu Arg 
                565                 570                 575     


Lys Leu Ser Tyr Pro Asp Trp Gly Ser Gly Cys Tyr Gln Val Ser Cys 
            580                 585                 590         


Ser Pro Gln Gly Leu Lys Val Trp Val Gln Asp Thr Ser Tyr Leu Cys 
        595                 600                 605             


Ser Arg Ala Gly Gln Val Leu Pro Val Ser Ile Gln Met Asn Gly Trp 
    610                 615                 620                 


Ile His Asp Gly Asn Leu Leu Cys Pro Ser Cys Trp Asp Phe Cys Glu 
625                 630                 635                 640 


Leu Cys Pro Pro Glu Thr Asp Pro Pro Ala Thr Asn Leu Thr Arg Ala 
                645                 650                 655     


Leu Pro Leu Asp Leu Cys Ser Cys Ser Ser Ser Leu Val Val Thr Leu 
            660                 665                 670         


Trp Leu Leu Leu Gly Asn Leu Phe Pro Leu Leu Ala Gly Phe Leu Leu 
        675                 680                 685             


Cys Ile Trp His 
    690         


<210>  6257
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMNA__Homo_sapiens__NP_001244303

<400>  6257

Met Gly Asn Ser Glu Gly Cys Asn Thr Lys Lys Glu Gly Asp Leu Ile 
1               5                   10                  15      


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
            20                  25                  30          


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
        35                  40                  45              


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
    50                  55                  60                  


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
65                  70                  75                  80  


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
                85                  90                  95      


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
            100                 105                 110         


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
        115                 120                 125             


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
    130                 135                 140                 


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
145                 150                 155                 160 


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
                165                 170                 175     


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
            180                 185                 190         


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
        195                 200                 205             


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
    210                 215                 220                 


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
225                 230                 235                 240 


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
                245                 250                 255     


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
            260                 265                 270         


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
        275                 280                 285             


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
    290                 295                 300                 


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
305                 310                 315                 320 


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
                325                 330                 335     


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
            340                 345                 350         


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
        355                 360                 365             


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
    370                 375                 380                 


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
385                 390                 395                 400 


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
                405                 410                 415     


Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
            420                 425                 430         


Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
        435                 440                 445             


Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 
    450                 455                 460                 


Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 
465                 470                 475                 480 


Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 
                485                 490                 495     


Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 
            500                 505                 510         


Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 
        515                 520                 525             


Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 
    530                 535                 540                 


Ser Pro Gln Asn Cys Ser Ile Ile Gln Glu Met Gly Met Arg Trp Glu 
545                 550                 555                 560 


Val Glu Glu Gly Arg Arg Lys Val Ser Leu Ser Cys Leu Pro 
                565                 570                 


<210>  6258
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMNB1__Homo_sapiens__NP_005564

<400>  6258

Met Ala Thr Ala Thr Pro Val Pro Pro Arg Met Gly Ser Arg Ala Gly 
1               5                   10                  15      


Gly Pro Thr Thr Pro Leu Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu 
            20                  25                  30          


Lys Glu Glu Leu Arg Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp 
        35                  40                  45              


Lys Val Arg Ser Leu Glu Thr Glu Asn Ser Ala Leu Gln Leu Gln Val 
    50                  55                  60                  


Thr Glu Arg Glu Glu Val Arg Gly Arg Glu Leu Thr Gly Leu Lys Ala 
65                  70                  75                  80  


Leu Tyr Glu Thr Glu Leu Ala Asp Ala Arg Arg Ala Leu Asp Asp Thr 
                85                  90                  95      


Ala Arg Glu Arg Ala Lys Leu Gln Ile Glu Leu Gly Lys Cys Lys Ala 
            100                 105                 110         


Glu His Asp Gln Leu Leu Leu Asn Tyr Ala Lys Lys Glu Ser Asp Leu 
        115                 120                 125             


Asn Gly Ala Gln Ile Lys Leu Arg Glu Tyr Glu Ala Ala Leu Asn Ser 
    130                 135                 140                 


Lys Asp Ala Ala Leu Ala Thr Ala Leu Gly Asp Lys Lys Ser Leu Glu 
145                 150                 155                 160 


Gly Asp Leu Glu Asp Leu Lys Asp Gln Ile Ala Gln Leu Glu Ala Ser 
                165                 170                 175     


Leu Ala Ala Ala Lys Lys Gln Leu Ala Asp Glu Thr Leu Leu Lys Val 
            180                 185                 190         


Asp Leu Glu Asn Arg Cys Gln Ser Leu Thr Glu Asp Leu Glu Phe Arg 
        195                 200                 205             


Lys Ser Met Tyr Glu Glu Glu Ile Asn Glu Thr Arg Arg Lys His Glu 
    210                 215                 220                 


Thr Arg Leu Val Glu Val Asp Ser Gly Arg Gln Ile Glu Tyr Glu Tyr 
225                 230                 235                 240 


Lys Leu Ala Gln Ala Leu His Glu Met Arg Glu Gln His Asp Ala Gln 
                245                 250                 255     


Val Arg Leu Tyr Lys Glu Glu Leu Glu Gln Thr Tyr His Ala Lys Leu 
            260                 265                 270         


Glu Asn Ala Arg Leu Ser Ser Glu Met Asn Thr Ser Thr Val Asn Ser 
        275                 280                 285             


Ala Arg Glu Glu Leu Met Glu Ser Arg Met Arg Ile Glu Ser Leu Ser 
    290                 295                 300                 


Ser Gln Leu Ser Asn Leu Gln Lys Glu Ser Arg Ala Cys Leu Glu Arg 
305                 310                 315                 320 


Ile Gln Glu Leu Glu Asp Leu Leu Ala Lys Glu Lys Asp Asn Ser Arg 
                325                 330                 335     


Arg Met Leu Thr Asp Lys Glu Arg Glu Met Ala Glu Ile Arg Asp Gln 
            340                 345                 350         


Met Gln Gln Gln Leu Asn Asp Tyr Glu Gln Leu Leu Asp Val Lys Leu 
        355                 360                 365             


Ala Leu Asp Met Glu Ile Ser Ala Tyr Arg Lys Leu Leu Glu Gly Glu 
    370                 375                 380                 


Glu Glu Arg Leu Lys Leu Ser Pro Ser Pro Ser Ser Arg Val Thr Val 
385                 390                 395                 400 


Ser Arg Ala Ser Ser Ser Arg Ser Val Arg Thr Thr Arg Gly Lys Arg 
                405                 410                 415     


Lys Arg Val Asp Val Glu Glu Ser Glu Ala Ser Ser Ser Val Ser Ile 
            420                 425                 430         


Ser His Ser Ala Ser Ala Thr Gly Asn Val Cys Ile Glu Glu Ile Asp 
        435                 440                 445             


Val Asp Gly Lys Phe Ile Arg Leu Lys Asn Thr Ser Glu Gln Asp Gln 
    450                 455                 460                 


Pro Met Gly Gly Trp Glu Met Ile Arg Lys Ile Gly Asp Thr Ser Val 
465                 470                 475                 480 


Ser Tyr Lys Tyr Thr Ser Arg Tyr Val Leu Lys Ala Gly Gln Thr Val 
                485                 490                 495     


Thr Ile Trp Ala Ala Asn Ala Gly Val Thr Ala Ser Pro Pro Thr Asp 
            500                 505                 510         


Leu Ile Trp Lys Asn Gln Asn Ser Trp Gly Thr Gly Glu Asp Val Lys 
        515                 520                 525             


Val Ile Leu Lys Asn Ser Gln Gly Glu Glu Val Ala Gln Arg Ser Thr 
    530                 535                 540                 


Val Phe Lys Thr Thr Ile Pro Glu Glu Glu Glu Glu Glu Glu Glu Ala 
545                 550                 555                 560 


Ala Gly Val Val Val Glu Glu Glu Leu Phe His Gln Gln Gly Thr Pro 
                565                 570                 575     


Arg Ala Ser Asn Arg Ser Cys Ala Ile Met 
            580                 585     


<210>  6259
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMNB2__Homo_sapiens__NP_116126

<400>  6259

Met Ser Pro Pro Ser Pro Gly Arg Arg Arg Glu Gln Arg Arg Pro Arg 
1               5                   10                  15      


Ala Ala Ala Thr Met Ala Thr Pro Leu Pro Gly Arg Ala Gly Gly Pro 
            20                  25                  30          


Ala Thr Pro Leu Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu Lys Glu 
        35                  40                  45              


Glu Leu Arg Glu Leu Asn Asp Arg Leu Ala His Tyr Ile Asp Arg Val 
    50                  55                  60                  


Arg Ala Leu Glu Leu Glu Asn Asp Arg Leu Leu Leu Lys Ile Ser Glu 
65                  70                  75                  80  


Lys Glu Glu Val Thr Thr Arg Glu Val Ser Gly Ile Lys Ala Leu Tyr 
                85                  90                  95      


Glu Ser Glu Leu Ala Asp Ala Arg Arg Val Leu Asp Glu Thr Ala Arg 
            100                 105                 110         


Glu Arg Ala Arg Leu Gln Ile Glu Ile Gly Lys Leu Arg Ala Glu Leu 
        115                 120                 125             


Asp Glu Val Asn Lys Ser Ala Lys Lys Arg Glu Gly Glu Leu Thr Val 
    130                 135                 140                 


Ala Gln Gly Arg Val Lys Asp Leu Glu Ser Leu Phe His Arg Ser Glu 
145                 150                 155                 160 


Val Glu Leu Ala Ala Ala Leu Ser Asp Lys Arg Gly Leu Glu Ser Asp 
                165                 170                 175     


Val Ala Glu Leu Arg Ala Gln Leu Ala Lys Ala Glu Asp Gly His Ala 
            180                 185                 190         


Val Ala Lys Lys Gln Leu Glu Lys Glu Thr Leu Met Arg Val Asp Leu 
        195                 200                 205             


Glu Asn Arg Cys Gln Ser Leu Gln Glu Glu Leu Asp Phe Arg Lys Ser 
    210                 215                 220                 


Val Phe Glu Glu Glu Val Arg Glu Thr Arg Arg Arg His Glu Arg Arg 
225                 230                 235                 240 


Leu Val Glu Val Asp Ser Ser Arg Gln Gln Glu Tyr Asp Phe Lys Met 
                245                 250                 255     


Ala Gln Ala Leu Glu Glu Leu Arg Ser Gln His Asp Glu Gln Val Arg 
            260                 265                 270         


Leu Tyr Lys Leu Glu Leu Glu Gln Thr Tyr Gln Ala Lys Leu Asp Ser 
        275                 280                 285             


Ala Lys Leu Ser Ser Asp Gln Asn Asp Lys Ala Ala Ser Ala Ala Arg 
    290                 295                 300                 


Glu Glu Leu Lys Glu Ala Arg Met Arg Leu Glu Ser Leu Ser Tyr Gln 
305                 310                 315                 320 


Leu Ser Gly Leu Gln Lys Gln Ala Ser Ala Ala Glu Asp Arg Ile Arg 
                325                 330                 335     


Glu Leu Glu Glu Ala Met Ala Gly Glu Arg Asp Lys Phe Arg Lys Met 
            340                 345                 350         


Leu Asp Ala Lys Glu Gln Glu Met Thr Glu Met Arg Asp Val Met Gln 
        355                 360                 365             


Gln Gln Leu Ala Glu Tyr Gln Glu Leu Leu Asp Val Lys Leu Ala Leu 
    370                 375                 380                 


Asp Met Glu Ile Asn Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Glu 
385                 390                 395                 400 


Arg Leu Lys Leu Ser Pro Ser Pro Ser Ser Arg Val Thr Val Ser Arg 
                405                 410                 415     


Ala Thr Ser Ser Ser Ser Gly Ser Leu Ser Ala Thr Gly Arg Leu Gly 
            420                 425                 430         


Arg Ser Lys Arg Lys Arg Leu Glu Val Glu Glu Pro Leu Gly Ser Gly 
        435                 440                 445             


Pro Ser Val Leu Gly Thr Gly Thr Gly Gly Ser Gly Gly Phe His Leu 
    450                 455                 460                 


Ala Gln Gln Ala Ser Ala Ser Gly Ser Val Ser Ile Glu Glu Ile Asp 
465                 470                 475                 480 


Leu Glu Gly Lys Phe Val Gln Leu Lys Asn Asn Ser Asp Lys Asp Gln 
                485                 490                 495     


Ser Leu Gly Asn Trp Arg Ile Lys Arg Gln Val Leu Glu Gly Glu Glu 
            500                 505                 510         


Ile Ala Tyr Lys Phe Thr Pro Lys Tyr Ile Leu Arg Ala Gly Gln Met 
        515                 520                 525             


Val Thr Val Trp Ala Ala Gly Ala Gly Val Ala His Ser Pro Pro Ser 
    530                 535                 540                 


Thr Leu Val Trp Lys Gly Gln Ser Ser Trp Gly Thr Gly Glu Ser Phe 
545                 550                 555                 560 


Arg Thr Val Leu Val Asn Ala Asp Gly Glu Glu Val Ala Met Arg Thr 
                565                 570                 575     


Val Lys Lys Ser Ser Val Met Arg Glu Asn Glu Asn Gly Glu Glu Glu 
            580                 585                 590         


Glu Glu Glu Ala Glu Phe Gly Glu Glu Asp Leu Phe His Gln Gln Gly 
        595                 600                 605             


Asp Pro Arg Thr Thr Ser Arg Gly Cys Tyr Val Met 
    610                 615                 620 


<210>  6260
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMNTD1__Homo_sapiens__NP_001139199

<400>  6260

Met Gln Gln Pro Val Arg Ala Gly Asp Ile Gly Val Ser Arg Val Gln 
1               5                   10                  15      


Thr His His Asn Ala Ser Pro Phe Ser Val Pro Lys Lys Gln Asp Glu 
            20                  25                  30          


Ser Pro Met Ile Gly Asp Gly Glu Asp Tyr Phe Leu Ser Leu Phe Gly 
        35                  40                  45              


Asp Ser Lys Lys Leu Thr Ala His Ser Asn Tyr Thr Gln Lys Thr Leu 
    50                  55                  60                  


Lys Tyr Phe Ser Met Ile Leu Glu Glu Val Gly Gln Phe Thr Ser Ser 
65                  70                  75                  80  


Ser Leu Gly Asp Val Glu Ile Ala Glu Val Asn Val Lys Gly Leu Phe 
                85                  90                  95      


Val Lys Leu Ile Asn Ser Ser Leu Asp Lys Glu Met Ala Ile Gly Asp 
            100                 105                 110         


His Ile Leu Gln Gln Asn Val Asn Gly Gln Thr Ile Ser Leu Tyr Arg 
        115                 120                 125             


Phe Leu Pro Asn Ile Val Met Gln Ala Asn Ser Thr Val Thr Val Trp 
    130                 135                 140                 


Ala Ala Ala Ser Glu Ala Lys His Gln Pro Pro Ser Asp Phe Leu Trp 
145                 150                 155                 160 


Lys Glu Gln Asp Lys Phe Arg Ala Ser Pro Asp Cys Ile Thr Ile Leu 
                165                 170                 175     


Cys Lys Pro Asn Gly Gln Ala Ile Ala Trp Tyr Thr Pro Ile His Trp 
            180                 185                 190         


Lys Gln Ala Trp Glu Lys Leu Asp Ala Asp Val Glu Phe Asn Arg Cys 
        195                 200                 205             


Ser Val Val Ser Pro Thr Phe Arg Lys Arg Val Phe Gln Trp Thr Ala 
    210                 215                 220                 


Ser Thr Ala Thr Ile Thr Lys Glu Lys Gln Asp Gln Pro Lys Lys Asp 
225                 230                 235                 240 


Ile Ser Asn Tyr Gln Val Glu Gln Ala Gln Val Leu Leu Lys Arg Glu 
                245                 250                 255     


Lys Glu Ile Pro Pro Thr Val Phe Pro Asn Arg Ser Pro Trp Cys Gln 
            260                 265                 270         


Asn Pro Tyr Val Ser Ala His Pro Tyr Cys Pro Leu Ile Glu Pro His 
        275                 280                 285             


Asn Thr Ser Thr Ala Gly Gly Arg Leu Asp Arg Gln Pro Arg Thr Arg 
    290                 295                 300                 


Ser Thr Arg Pro Asn Arg Ala Ser Gly Ser Lys Lys Lys Lys Thr Ser 
305                 310                 315                 320 


Glu Ser Gln Lys Gln 
                325 


<210>  6261
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMO1__Homo_sapiens__NP_001257357

<400>  6261

Met Val Leu Asp Gln Glu Asp Gly Val Pro Met Leu Ser Val Gln Pro 
1               5                   10                  15      


Lys Gly Lys Gln Lys Gly Cys Ala Gly Cys Asn Arg Lys Ile Lys Asp 
            20                  25                  30          


Arg Tyr Leu Leu Lys Ala Leu Asp Lys Tyr Trp His Glu Asp Cys Leu 
        35                  40                  45              


Lys Cys Ala Cys Cys Asp Cys Arg Leu Gly Glu Val Gly Ser Thr Leu 
    50                  55                  60                  


Tyr Thr Lys Ala Asn Leu Ile Leu Cys Arg Arg Asp Tyr Leu Arg Leu 
65                  70                  75                  80  


Phe Gly Thr Thr Gly Asn Cys Ala Ala Cys Ser Lys Leu Ile Pro Ala 
                85                  90                  95      


Phe Glu Met Val Met Arg Ala Arg Asp Asn Val Tyr His Leu Asp Cys 
            100                 105                 110         


Phe Ala Cys Gln Leu Cys Asn Gln Arg Phe Cys Val Gly Asp Lys Phe 
        115                 120                 125             


Phe Leu Lys Asn Asn Met Ile Leu Cys Gln Met Asp Tyr Glu Glu Gly 
    130                 135                 140                 


Gln Leu Asn Gly Thr Phe Glu Ser Gln Val Gln 
145                 150                 155 


<210>  6262
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMO2__Homo_sapiens__NP_001135787

<400>  6262

Met Ser Ser Ala Ile Glu Arg Lys Ser Leu Asp Pro Ser Glu Glu Pro 
1               5                   10                  15      


Val Asp Glu Val Leu Gln Ile Pro Pro Ser Leu Leu Thr Cys Gly Gly 
            20                  25                  30          


Cys Gln Gln Asn Ile Gly Asp Arg Tyr Phe Leu Lys Ala Ile Asp Gln 
        35                  40                  45              


Tyr Trp His Glu Asp Cys Leu Ser Cys Asp Leu Cys Gly Cys Arg Leu 
    50                  55                  60                  


Gly Glu Val Gly Arg Arg Leu Tyr Tyr Lys Leu Gly Arg Lys Leu Cys 
65                  70                  75                  80  


Arg Arg Asp Tyr Leu Arg Leu Phe Gly Gln Asp Gly Leu Cys Ala Ser 
                85                  90                  95      


Cys Asp Lys Arg Ile Arg Ala Tyr Glu Met Thr Met Arg Val Lys Asp 
            100                 105                 110         


Lys Val Tyr His Leu Glu Cys Phe Lys Cys Ala Ala Cys Gln Lys His 
        115                 120                 125             


Phe Cys Val Gly Asp Arg Tyr Leu Leu Ile Asn Ser Asp Ile Val Cys 
    130                 135                 140                 


Glu Gln Asp Ile Tyr Glu Trp Thr Lys Ile Asn Gly Met Ile 
145                 150                 155             


<210>  6263
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMO3__Homo_sapiens__NP_001001395

<400>  6263

Met Leu Ser Val Gln Pro Asp Thr Lys Pro Lys Gly Cys Ala Gly Cys 
1               5                   10                  15      


Asn Arg Lys Ile Lys Asp Arg Tyr Leu Leu Lys Ala Leu Asp Lys Tyr 
            20                  25                  30          


Trp His Glu Asp Cys Leu Lys Cys Ala Cys Cys Asp Cys Arg Leu Gly 
        35                  40                  45              


Glu Val Gly Ser Thr Leu Tyr Thr Lys Ala Asn Leu Ile Leu Cys Arg 
    50                  55                  60                  


Arg Asp Tyr Leu Arg Leu Phe Gly Val Thr Gly Asn Cys Ala Ala Cys 
65                  70                  75                  80  


Ser Lys Leu Ile Pro Ala Phe Glu Met Val Met Arg Ala Lys Asp Asn 
                85                  90                  95      


Val Tyr His Leu Asp Cys Phe Ala Cys Gln Leu Cys Asn Gln Arg Phe 
            100                 105                 110         


Cys Val Gly Asp Lys Phe Phe Leu Lys Asn Asn Met Ile Leu Cys Gln 
        115                 120                 125             


Thr Asp Tyr Glu Glu Gly Leu Met Lys Glu Gly Tyr Ala Pro Gln Val 
    130                 135                 140                 


Arg 
145 


<210>  6264
<211>  1349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMO7__Homo_sapiens__NP_005349

<400>  6264

Met Lys Lys Ile Arg Ile Cys His Ile Phe Thr Phe Tyr Ser Trp Met 
1               5                   10                  15      


Ser Tyr Asp Val Leu Phe Gln Arg Thr Glu Leu Gly Ala Leu Glu Ile 
            20                  25                  30          


Trp Arg Gln Leu Ile Cys Ala His Val Cys Ile Cys Val Gly Trp Leu 
        35                  40                  45              


Tyr Leu Arg Asp Arg Val Cys Ser Lys Lys Asp Ile Ile Leu Arg Thr 
    50                  55                  60                  


Glu Gln Asn Ser Gly Arg Thr Ile Leu Ile Lys Ala Val Thr Glu Lys 
65                  70                  75                  80  


Asn Phe Glu Thr Lys Asp Phe Arg Ala Ser Leu Glu Asn Gly Val Leu 
                85                  90                  95      


Leu Cys Asp Leu Ile Asn Lys Leu Lys Pro Gly Val Ile Lys Lys Ile 
            100                 105                 110         


Asn Arg Leu Ser Thr Pro Ile Ala Gly Leu Asp Asn Ile Asn Val Phe 
        115                 120                 125             


Leu Lys Ala Cys Glu Gln Ile Gly Leu Lys Glu Ala Gln Leu Phe His 
    130                 135                 140                 


Pro Gly Asp Leu Gln Asp Leu Ser Asn Arg Val Thr Val Lys Gln Glu 
145                 150                 155                 160 


Glu Thr Asp Arg Arg Val Lys Asn Val Leu Ile Thr Leu Tyr Trp Leu 
                165                 170                 175     


Gly Arg Lys Ala Gln Ser Asn Pro Tyr Tyr Asn Gly Pro His Leu Asn 
            180                 185                 190         


Leu Lys Ala Phe Glu Asn Leu Leu Gly Gln Ala Leu Thr Lys Ala Leu 
        195                 200                 205             


Glu Asp Ser Ser Phe Leu Lys Arg Ser Gly Arg Asp Ser Gly Tyr Gly 
    210                 215                 220                 


Asp Ile Trp Cys Pro Glu Arg Gly Glu Phe Leu Ala Pro Pro Arg His 
225                 230                 235                 240 


His Lys Arg Glu Asp Ser Phe Glu Ser Leu Asp Ser Leu Gly Ser Arg 
                245                 250                 255     


Ser Leu Thr Ser Cys Ser Ser Asp Ile Thr Leu Arg Gly Gly Arg Glu 
            260                 265                 270         


Gly Phe Glu Ser Asp Thr Asp Ser Glu Phe Thr Phe Lys Met Gln Asp 
        275                 280                 285             


Tyr Asn Lys Asp Asp Met Ser Tyr Arg Arg Ile Ser Ala Val Glu Pro 
    290                 295                 300                 


Lys Thr Ala Leu Pro Phe Asn Arg Phe Leu Pro Asn Lys Ser Arg Gln 
305                 310                 315                 320 


Pro Ser Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Pro Asp Lys His 
                325                 330                 335     


Glu Asp Asn Arg Arg Ser Trp Ala Ser Pro Val Tyr Thr Glu Ala Asp 
            340                 345                 350         


Gly Thr Phe Ser Arg Leu Phe Gln Lys Ile Tyr Gly Glu Asn Gly Ser 
        355                 360                 365             


Lys Ser Met Ser Asp Val Ser Ala Glu Asp Val Gln Asn Leu Arg Gln 
    370                 375                 380                 


Leu Arg Tyr Glu Glu Met Gln Lys Ile Lys Ser Gln Leu Lys Glu Gln 
385                 390                 395                 400 


Asp Gln Lys Trp Gln Asp Asp Leu Ala Lys Trp Lys Asp Arg Arg Lys 
                405                 410                 415     


Ser Tyr Thr Ser Asp Leu Gln Lys Lys Lys Glu Glu Arg Glu Glu Ile 
            420                 425                 430         


Glu Lys Gln Ala Leu Glu Lys Ser Lys Arg Ser Ser Lys Thr Phe Lys 
        435                 440                 445             


Glu Met Leu Gln Asp Arg Glu Ser Gln Asn Gln Lys Ser Thr Val Pro 
    450                 455                 460                 


Ser Arg Arg Arg Met Tyr Ser Phe Asp Asp Val Leu Glu Glu Gly Lys 
465                 470                 475                 480 


Arg Pro Pro Thr Met Thr Val Ser Glu Ala Ser Tyr Gln Ser Glu Arg 
                485                 490                 495     


Val Glu Glu Lys Gly Ala Thr Tyr Pro Ser Glu Ile Pro Lys Glu Asp 
            500                 505                 510         


Ser Thr Thr Phe Ala Lys Arg Glu Asp Arg Val Thr Thr Glu Ile Gln 
        515                 520                 525             


Leu Pro Ser Gln Ser Pro Val Glu Glu Gln Ser Pro Ala Ser Leu Ser 
    530                 535                 540                 


Ser Leu Arg Ser Arg Ser Thr Gln Met Glu Ser Thr Arg Val Ser Ala 
545                 550                 555                 560 


Ser Leu Pro Arg Ser Tyr Arg Lys Thr Asp Thr Val Arg Leu Thr Ser 
                565                 570                 575     


Val Val Thr Pro Arg Pro Phe Gly Ser Gln Thr Arg Gly Ile Ser Ser 
            580                 585                 590         


Leu Pro Arg Ser Tyr Thr Met Asp Asp Ala Trp Lys Tyr Asn Gly Asp 
        595                 600                 605             


Val Glu Asp Ile Lys Arg Thr Pro Asn Asn Val Val Ser Thr Pro Ala 
    610                 615                 620                 


Pro Ser Pro Asp Ala Ser Gln Leu Ala Ser Ser Leu Ser Ser Gln Lys 
625                 630                 635                 640 


Glu Val Ala Ala Thr Glu Glu Asp Val Thr Arg Leu Pro Ser Pro Thr 
                645                 650                 655     


Ser Pro Phe Ser Ser Leu Ser Gln Asp Gln Ala Ala Thr Ser Lys Ala 
            660                 665                 670         


Thr Leu Ser Ser Thr Ser Gly Leu Asp Leu Met Ser Glu Ser Gly Glu 
        675                 680                 685             


Gly Glu Ile Ser Pro Gln Arg Glu Val Ser Arg Ser Gln Asp Gln Phe 
    690                 695                 700                 


Ser Asp Met Arg Ile Ser Ile Asn Gln Thr Pro Gly Lys Ser Leu Asp 
705                 710                 715                 720 


Phe Gly Phe Thr Ile Lys Trp Asp Ile Pro Gly Ile Phe Val Ala Ser 
                725                 730                 735     


Val Glu Ala Gly Ser Pro Ala Glu Phe Ser Gln Leu Gln Val Asp Asp 
            740                 745                 750         


Glu Ile Ile Ala Ile Asn Asn Thr Lys Phe Ser Tyr Asn Asp Ser Lys 
        755                 760                 765             


Glu Trp Glu Glu Ala Met Ala Lys Ala Gln Glu Thr Gly His Leu Val 
    770                 775                 780                 


Met Asp Val Arg Arg Tyr Gly Lys Ala Gly Ser Pro Glu Thr Lys Trp 
785                 790                 795                 800 


Ile Asp Ala Thr Ser Gly Ile Tyr Asn Ser Glu Lys Ser Ser Asn Leu 
                805                 810                 815     


Ser Val Thr Thr Asp Phe Ser Glu Ser Leu Gln Ser Ser Asn Ile Glu 
            820                 825                 830         


Ser Lys Glu Ile Asn Gly Ile His Asp Glu Ser Asn Ala Phe Glu Ser 
        835                 840                 845             


Lys Ala Ser Glu Ser Ile Ser Leu Lys Asn Leu Lys Arg Arg Ser Gln 
    850                 855                 860                 


Phe Phe Glu Gln Gly Ser Ser Asp Ser Val Val Pro Asp Leu Pro Val 
865                 870                 875                 880 


Pro Thr Ile Ser Ala Pro Ser Arg Trp Val Trp Asp Gln Glu Glu Glu 
                885                 890                 895     


Arg Lys Arg Gln Glu Arg Trp Gln Lys Glu Gln Asp Arg Leu Leu Gln 
            900                 905                 910         


Glu Lys Tyr Gln Arg Glu Gln Glu Lys Leu Arg Glu Glu Trp Gln Arg 
        915                 920                 925             


Ala Lys Gln Glu Ala Glu Arg Glu Asn Ser Lys Tyr Leu Asp Glu Glu 
    930                 935                 940                 


Leu Met Val Leu Ser Ser Asn Ser Met Ser Leu Thr Thr Arg Glu Pro 
945                 950                 955                 960 


Ser Leu Ala Thr Trp Glu Ala Thr Trp Ser Glu Gly Ser Lys Ser Ser 
                965                 970                 975     


Asp Arg Glu Gly Thr Arg Ala Gly Glu Glu Glu Arg Arg Gln Pro Gln 
            980                 985                 990         


Glu Glu Val Val His Glu Asp Gln  Gly Lys Lys Pro Gln  Asp Gln Leu 
        995                 1000                 1005             


Val Ile  Glu Arg Glu Arg Lys  Trp Glu Gln Gln Leu  Gln Glu Glu 
    1010                 1015                 1020             


Gln Glu  Gln Lys Arg Leu Gln  Ala Glu Ala Glu Glu  Gln Lys Arg 
    1025                 1030                 1035             


Pro Ala  Glu Glu Gln Lys Arg  Gln Ala Glu Ile Glu  Arg Glu Thr 
    1040                 1045                 1050             


Ser Val  Arg Ile Tyr Gln Tyr  Arg Arg Pro Val Asp  Ser Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Lys Thr Glu Glu Ala  Ser Ser Gly Phe Leu  Pro Gly Asp 
    1070                 1075                 1080             


Arg Asn  Lys Ser Arg Ser Thr  Thr Glu Leu Asp Asp  Tyr Ser Thr 
    1085                 1090                 1095             


Asn Lys  Asn Gly Asn Asn Lys  Tyr Leu Asp Gln Ile  Gly Asn Met 
    1100                 1105                 1110             


Thr Ser  Ser Gln Arg Arg Ser  Lys Lys Glu Gln Val  Pro Ser Gly 
    1115                 1120                 1125             


Ala Glu  Leu Glu Arg Gln Gln  Ile Leu Gln Glu Met  Arg Lys Arg 
    1130                 1135                 1140             


Thr Pro  Leu His Asn Asp Asn  Ser Trp Ile Arg Gln  Arg Ser Ala 
    1145                 1150                 1155             


Ser Val  Asn Lys Glu Pro Val  Ser Leu Pro Gly Ile  Met Arg Arg 
    1160                 1165                 1170             


Gly Glu  Ser Leu Asp Asn Leu  Asp Ser Pro Arg Ser  Asn Ser Trp 
    1175                 1180                 1185             


Arg Gln  Pro Pro Trp Leu Asn  Gln Pro Thr Gly Phe  Tyr Ala Ser 
    1190                 1195                 1200             


Ser Ser  Val Gln Asp Phe Ser  Arg Pro Pro Pro Gln  Leu Val Ser 
    1205                 1210                 1215             


Thr Ser  Asn Arg Ala Tyr Met  Arg Asn Pro Ser Ser  Ser Val Pro 
    1220                 1225                 1230             


Pro Pro  Ser Ala Gly Ser Val  Lys Thr Ser Thr Thr  Gly Val Ala 
    1235                 1240                 1245             


Thr Thr  Gln Ser Pro Thr Pro  Arg Ser His Ser Pro  Ser Ala Ser 
    1250                 1255                 1260             


Gln Ser  Gly Ser Gln Leu Arg  Asn Arg Ser Val Ser  Gly Lys Arg 
    1265                 1270                 1275             


Ile Cys  Ser Tyr Cys Asn Asn  Ile Leu Gly Lys Gly  Ala Ala Met 
    1280                 1285                 1290             


Ile Ile  Glu Ser Leu Gly Leu  Cys Tyr His Leu His  Cys Phe Lys 
    1295                 1300                 1305             


Cys Val  Ala Cys Glu Cys Asp  Leu Gly Gly Ser Ser  Ser Gly Ala 
    1310                 1315                 1320             


Glu Val  Arg Ile Arg Asn His  Gln Leu Tyr Cys Asn  Asp Cys Tyr 
    1325                 1330                 1335             


Leu Arg  Phe Lys Ser Gly Arg  Pro Thr Ala Met 
    1340                 1345                 


<210>  6265
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMOD1__Homo_sapiens__NP_036266

<400>  6265

Met Ser Arg Val Ala Lys Tyr Arg Arg Gln Val Ser Glu Asp Pro Asp 
1               5                   10                  15      


Ile Asp Ser Leu Leu Glu Thr Leu Ser Pro Glu Glu Met Glu Glu Leu 
            20                  25                  30          


Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser Val Pro Val Gly 
        35                  40                  45              


Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr Gly Val Tyr Asn 
    50                  55                  60                  


Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr Lys Lys Leu Met 
65                  70                  75                  80  


Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val Glu Thr Lys Thr 
                85                  90                  95      


Asp Ala Lys Asn Gly Glu Glu Arg Gly Arg Asp Ala Ser Lys Lys Ala 
            100                 105                 110         


Leu Gly Pro Arg Arg Asp Ser Asp Leu Gly Lys Glu Pro Lys Arg Gly 
        115                 120                 125             


Gly Leu Lys Lys Ser Phe Ser Arg Asp Arg Asp Glu Ala Gly Gly Lys 
    130                 135                 140                 


Ser Gly Glu Lys Pro Lys Glu Glu Lys Ile Ile Arg Gly Ile Asp Lys 
145                 150                 155                 160 


Gly Arg Val Arg Ala Ala Val Asp Lys Lys Glu Ala Gly Lys Asp Gly 
                165                 170                 175     


Arg Gly Glu Glu Arg Ala Val Ala Thr Lys Lys Glu Glu Glu Lys Lys 
            180                 185                 190         


Gly Ser Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys Asp Lys Lys Arg 
        195                 200                 205             


Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp Glu Lys Val Lys 
    210                 215                 220                 


Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly Glu Lys Met Lys 
225                 230                 235                 240 


Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp Glu Lys Val Lys 
                245                 250                 255     


Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp Glu Lys Val Lys 
            260                 265                 270         


Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp Asp Ser Lys Thr 
        275                 280                 285             


Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr Lys Pro Ser Glu 
    290                 295                 300                 


Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser Ile Phe Asp Glu 
305                 310                 315                 320 


Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met Thr Glu Val Asn 
                325                 330                 335     


Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu Val Arg Phe Thr 
            340                 345                 350         


Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe Ala Leu Ala Asn 
        355                 360                 365             


Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala Ile Met Leu Lys 
    370                 375                 380                 


Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser Asn His Ile Thr 
385                 390                 395                 400 


Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu Gln Asn Asn Thr 
                405                 410                 415     


Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile Cys Gly Gly Lys 
            420                 425                 430         


Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn Thr Thr Leu Leu 
        435                 440                 445             


Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg Met Thr Val Thr 
    450                 455                 460                 


Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln Lys Arg Leu Gln 
465                 470                 475                 480 


Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys Lys Asp Leu Leu 
                485                 490                 495     


Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser Pro Lys Pro Ser 
            500                 505                 510         


Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser Pro Lys Lys Gly 
        515                 520                 525             


Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Leu Ala Pro Pro 
    530                 535                 540                 


Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro Ala Thr Gln Arg 
545                 550                 555                 560 


Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys Asn Ser Arg Asp 
                565                 570                 575     


Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys Gln Leu Lys Lys 
            580                 585                 590         


Val Glu Val Pro Lys Leu Leu Gln 
        595                 600 


<210>  6266
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMOD3__Homo_sapiens__NP_001291347

<400>  6266

Met Ser Glu His Ser Arg Asn Ser Asp Gln Glu Glu Leu Leu Asp Glu 
1               5                   10                  15      


Glu Ile Asn Glu Asp Glu Ile Leu Ala Asn Leu Ser Ala Glu Glu Leu 
            20                  25                  30          


Lys Glu Leu Gln Ser Glu Met Glu Val Met Ala Pro Asp Pro Ser Leu 
        35                  40                  45              


Pro Val Gly Met Ile Gln Lys Asp Gln Thr Asp Lys Pro Pro Thr Gly 
    50                  55                  60                  


Asn Phe Asn His Lys Ser Leu Val Asp Tyr Met Tyr Trp Glu Lys Ala 
65                  70                  75                  80  


Ser Arg Arg Met Leu Glu Glu Glu Arg Val Pro Val Thr Phe Val Lys 
                85                  90                  95      


Ser Glu Glu Lys Thr Gln Glu Glu His Glu Glu Ile Glu Lys Arg Asn 
            100                 105                 110         


Lys Asn Met Ala Gln Tyr Leu Lys Glu Lys Leu Asn Asn Glu Ile Val 
        115                 120                 125             


Ala Asn Lys Arg Glu Ser Lys Gly Ser Ser Asn Ile Gln Glu Thr Asp 
    130                 135                 140                 


Glu Glu Asp Glu Glu Glu Glu Asp Asp Asp Asp Asp Asp Glu Gly Glu 
145                 150                 155                 160 


Asp Asp Gly Glu Glu Ser Glu Glu Thr Asn Arg Glu Glu Glu Gly Lys 
                165                 170                 175     


Ala Lys Glu Gln Ile Arg Asn Cys Glu Asn Asn Cys Gln Gln Val Thr 
            180                 185                 190         


Asp Lys Ala Phe Lys Glu Gln Arg Asp Arg Pro Glu Ala Gln Glu Gln 
        195                 200                 205             


Ser Glu Lys Lys Ile Ser Lys Leu Asp Pro Lys Lys Leu Ala Leu Asp 
    210                 215                 220                 


Thr Ser Phe Leu Lys Val Ser Thr Arg Pro Ser Gly Asn Gln Thr Asp 
225                 230                 235                 240 


Leu Asp Gly Ser Leu Arg Arg Val Arg Lys Asn Asp Pro Asp Met Lys 
                245                 250                 255     


Glu Leu Asn Leu Asn Asn Ile Glu Asn Ile Pro Lys Glu Met Leu Leu 
            260                 265                 270         


Asp Phe Val Asn Ala Met Lys Lys Asn Lys His Ile Lys Thr Phe Ser 
        275                 280                 285             


Leu Ala Asn Val Gly Ala Asp Glu Asn Val Ala Phe Ala Leu Ala Asn 
    290                 295                 300                 


Met Leu Arg Glu Asn Arg Ser Ile Thr Thr Leu Asn Ile Glu Ser Asn 
305                 310                 315                 320 


Phe Ile Thr Gly Lys Gly Ile Val Ala Ile Met Arg Cys Leu Gln Phe 
                325                 330                 335     


Asn Glu Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Met Leu 
            340                 345                 350         


Gly His His Ala Glu Met Glu Ile Ala Arg Leu Leu Lys Ala Asn Asn 
        355                 360                 365             


Thr Leu Leu Lys Met Gly Tyr His Phe Glu Leu Pro Gly Pro Arg Met 
    370                 375                 380                 


Val Val Thr Asn Leu Leu Thr Arg Asn Gln Asp Lys Gln Arg Gln Lys 
385                 390                 395                 400 


Arg Gln Glu Glu Gln Lys Gln Gln Gln Leu Lys Glu Gln Lys Lys Leu 
                405                 410                 415     


Ile Ala Met Leu Glu Asn Gly Leu Gly Leu Pro Pro Gly Met Trp Glu 
            420                 425                 430         


Leu Leu Gly Gly Pro Lys Pro Asp Ser Arg Met Gln Glu Phe Phe Gln 
        435                 440                 445             


Pro Pro Pro Pro Arg Pro Pro Asn Pro Gln Asn Val Pro Phe Ser Gln 
    450                 455                 460                 


Arg Ser Glu Met Met Lys Lys Pro Ser Gln Ala Pro Lys Tyr Arg Thr 
465                 470                 475                 480 


Asp Pro Asp Ser Phe Arg Val Val Lys Leu Lys Arg Ile Gln Arg Lys 
                485                 490                 495     


Ser Arg Met Pro Glu Ala Arg Glu Pro Pro Glu Lys Thr Asn Leu Lys 
            500                 505                 510         


Asp Val Ile Lys Thr Leu Lys Pro Val Pro Arg Asn Arg Pro Pro Pro 
        515                 520                 525             


Leu Val Glu Ile Thr Pro Arg Asp Gln Leu Leu Asn Asp Ile Arg His 
    530                 535                 540                 


Ser Ser Val Ala Tyr Leu Lys Pro Val Gln Leu Pro Lys Glu Leu Ala 
545                 550                 555                 560 


<210>  6267
<211>  1503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMTK2__Homo_sapiens__NP_055731

<400>  6267

Met Pro Gly Pro Pro Ala Leu Arg Arg Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Ile Ala Gly Ser Ala Gly Ala Ala Pro Leu Pro Gln Thr 
            20                  25                  30          


Gly Ala Gly Glu Ala Pro Pro Ala Ala Glu Val Ser Ser Ser Phe Val 
        35                  40                  45              


Ile Leu Cys Val Cys Ser Leu Ile Ile Leu Ile Val Leu Ile Ala Asn 
    50                  55                  60                  


Cys Val Ser Cys Cys Lys Asp Pro Glu Ile Asp Phe Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Asn Phe Asp Asp Glu Ile Asp Phe Thr Pro Pro Ala Glu Asp Thr 
                85                  90                  95      


Pro Ser Val Gln Ser Pro Ala Glu Val Phe Thr Leu Ser Val Pro Asn 
            100                 105                 110         


Ile Ser Leu Pro Ala Pro Ser Gln Phe Gln Pro Ser Val Glu Gly Leu 
        115                 120                 125             


Lys Ser Gln Val Ala Arg His Ser Leu Asn Tyr Ile Gln Glu Ile Gly 
    130                 135                 140                 


Asn Gly Trp Phe Gly Lys Val Leu Leu Gly Glu Ile Tyr Thr Gly Thr 
145                 150                 155                 160 


Ser Val Ala Arg Val Ile Val Lys Glu Leu Lys Ala Ser Ala Asn Pro 
                165                 170                 175     


Lys Glu Gln Asp Thr Phe Leu Lys Asn Gly Glu Pro Tyr Tyr Ile Leu 
            180                 185                 190         


Gln His Pro Asn Ile Leu Gln Cys Val Gly Gln Cys Val Glu Ala Ile 
        195                 200                 205             


Pro Tyr Leu Leu Val Phe Glu Phe Cys Asp Leu Gly Asp Leu Lys Ala 
    210                 215                 220                 


Tyr Leu Arg Ser Glu Gln Glu His Met Arg Gly Asp Ser Gln Thr Met 
225                 230                 235                 240 


Leu Leu Gln Arg Met Ala Cys Glu Val Ala Ala Gly Leu Ala Ala Met 
                245                 250                 255     


His Lys Leu His Phe Leu His Ser Asp Leu Ala Leu Arg Asn Cys Phe 
            260                 265                 270         


Leu Thr Ser Asp Leu Asn Val Lys Val Gly Asp Tyr Gly Ile Gly Phe 
        275                 280                 285             


Ser Arg Tyr Lys Glu Asp Tyr Ile Glu Thr Asp Asp Lys Lys Val Phe 
    290                 295                 300                 


Pro Leu Arg Trp Thr Ala Pro Glu Leu Val Thr Ser Phe Gln Asp Arg 
305                 310                 315                 320 


Leu Leu Thr Ala Asp Gln Thr Lys Tyr Ser Asn Ile Trp Ser Leu Gly 
                325                 330                 335     


Val Thr Leu Trp Glu Leu Phe Asp Asn Ala Ala Gln Pro Tyr Ser Asn 
            340                 345                 350         


Leu Ser Asn Leu Asp Val Leu Asn Gln Val Ile Arg Glu Arg Asp Thr 
        355                 360                 365             


Lys Leu Pro Lys Pro Gln Leu Glu Gln Pro Tyr Ser Asp Arg Trp Tyr 
    370                 375                 380                 


Glu Val Leu Gln Phe Cys Trp Leu Ser Pro Glu Lys Arg Pro Ala Ala 
385                 390                 395                 400 


Glu Asp Val His Arg Leu Leu Thr Tyr Leu Arg Leu Gln Ser Gln Arg 
                405                 410                 415     


Asp Ser Glu Val Asp Phe Glu Gln Gln Trp Asn Ala Leu Lys Pro Asn 
            420                 425                 430         


Thr Asn Ser Arg Asp Ser Ser Asn Asn Ala Ala Phe Pro Ile Leu Asp 
        435                 440                 445             


His Phe Ala Arg Asp Arg Leu Gly Arg Glu Met Glu Glu Val Leu Thr 
    450                 455                 460                 


Val Thr Glu Thr Ser Gln Gly Leu Ser Phe Glu Tyr Val Trp Glu Ala 
465                 470                 475                 480 


Ala Lys His Asp His Phe Asp Glu Arg Ser Arg Gly His Leu Asp Glu 
                485                 490                 495     


Gly Leu Ser Tyr Thr Ser Ile Phe Tyr Pro Val Glu Val Phe Glu Ser 
            500                 505                 510         


Ser Leu Ser Asp Pro Gly Pro Gly Lys Gln Asp Asp Ser Gly Gln Asp 
        515                 520                 525             


Val Pro Leu Arg Val Pro Gly Val Val Pro Val Phe Asp Ala His Asn 
    530                 535                 540                 


Leu Ser Val Gly Ser Asp Tyr Tyr Ile Gln Leu Glu Glu Lys Ser Gly 
545                 550                 555                 560 


Ser Asn Leu Glu Leu Asp Tyr Pro Pro Ala Leu Leu Thr Thr Asp Met 
                565                 570                 575     


Asp Asn Pro Glu Arg Thr Gly Pro Glu Leu Ser Gln Leu Thr Ala Leu 
            580                 585                 590         


Arg Ser Val Glu Leu Glu Glu Ser Ser Thr Asp Glu Asp Phe Phe Gln 
        595                 600                 605             


Ser Ser Thr Asp Pro Lys Asp Ser Ser Leu Pro Gly Asp Leu His Val 
    610                 615                 620                 


Thr Ser Gly Pro Glu Ser Pro Phe Asn Asn Ile Phe Asn Asp Val Asp 
625                 630                 635                 640 


Lys Ser Glu Asp Leu Pro Ser His Gln Lys Ile Phe Asp Leu Met Glu 
                645                 650                 655     


Leu Asn Gly Val Gln Ala Asp Phe Lys Pro Ala Thr Leu Ser Ser Ser 
            660                 665                 670         


Leu Asp Asn Pro Lys Glu Ser Val Ile Thr Gly His Phe Glu Lys Glu 
        675                 680                 685             


Lys Pro Arg Lys Ile Phe Asp Ser Glu Pro Leu Cys Leu Ser Asp Asn 
    690                 695                 700                 


Leu Met His Gln Asp Asn Phe Asp Pro Leu Asn Val Gln Glu Leu Ser 
705                 710                 715                 720 


Glu Asn Phe Leu Phe Leu Gln Glu Lys Asn Leu Leu Lys Gly Ser Leu 
                725                 730                 735     


Ser Ser Lys Glu His Ile Asn Asp Leu Gln Thr Glu Leu Lys Asn Ala 
            740                 745                 750         


Gly Phe Thr Glu Ala Met Leu Glu Thr Ser Cys Arg Asn Ser Leu Asp 
        755                 760                 765             


Thr Glu Leu Gln Phe Ala Glu Asn Lys Pro Gly Leu Ser Leu Leu Gln 
    770                 775                 780                 


Glu Asn Val Ser Thr Lys Gly Asp Asp Thr Asp Val Met Leu Thr Gly 
785                 790                 795                 800 


Asp Thr Leu Ser Thr Ser Leu Gln Ser Ser Pro Glu Val Gln Val Pro 
                805                 810                 815     


Pro Thr Ser Phe Glu Thr Glu Glu Thr Pro Arg Arg Val Pro Pro Asp 
            820                 825                 830         


Ser Leu Pro Thr Gln Gly Glu Thr Gln Pro Thr Cys Leu Asp Val Ile 
        835                 840                 845             


Val Pro Glu Asp Cys Leu His Gln Asp Ile Ser Pro Asp Ala Val Thr 
    850                 855                 860                 


Val Pro Val Glu Ile Leu Ser Thr Asp Ala Arg Thr His Ser Leu Asp 
865                 870                 875                 880 


Asn Arg Ser Gln Asp Ser Pro Gly Glu Ser Glu Glu Thr Leu Arg Leu 
                885                 890                 895     


Thr Glu Ser Asp Ser Val Leu Ala Asp Asp Ile Leu Ala Ser Arg Val 
            900                 905                 910         


Ser Val Gly Ser Ser Leu Pro Glu Leu Gly Gln Glu Leu His Asn Lys 
        915                 920                 925             


Pro Phe Ser Glu Asp His His Ser His Arg Arg Leu Glu Lys Asn Leu 
    930                 935                 940                 


Glu Ala Val Glu Thr Leu Asn Gln Leu Asn Ser Lys Asp Ala Ala Lys 
945                 950                 955                 960 


Glu Ala Gly Leu Val Ser Ala Leu Ser Ser Asp Ser Thr Ser Gln Asp 
                965                 970                 975     


Ser Leu Leu Glu Asp Ser Leu Ser Ala Pro Phe Pro Ala Ser Glu Pro 
            980                 985                 990         


Ser Leu Glu Thr Pro Asp Ser Leu  Glu Ser Val Asp Val  His Glu Ala 
        995                 1000                 1005             


Leu Leu  Asp Ser Leu Gly Ser  His Thr Pro Gln Lys  Leu Val Pro 
    1010                 1015                 1020             


Pro Asp  Lys Pro Ala Asp Ser  Gly Tyr Glu Thr Glu  Asn Leu Glu 
    1025                 1030                 1035             


Ser Pro  Glu Trp Thr Leu His  Pro Ala Pro Glu Gly  Thr Ala Asp 
    1040                 1045                 1050             


Ser Glu  Pro Ala Thr Thr Gly  Asp Gly Gly His Ser  Gly Leu Pro 
    1055                 1060                 1065             


Pro Asn  Pro Val Ile Val Ile  Ser Asp Ala Gly Asp  Gly His Arg 
    1070                 1075                 1080             


Gly Thr  Glu Val Thr Pro Glu  Thr Phe Thr Ala Gly  Ser Gln Gly 
    1085                 1090                 1095             


Ser Tyr  Arg Asp Ser Ala Tyr  Phe Ser Asp Asn Asp  Ser Glu Pro 
    1100                 1105                 1110             


Glu Lys  Arg Ser Glu Glu Val  Pro Gly Thr Ser Pro  Ser Ala Leu 
    1115                 1120                 1125             


Val Leu  Val Gln Glu Gln Pro  Leu Pro Glu Pro Val  Leu Pro Glu 
    1130                 1135                 1140             


Gln Ser  Pro Ala Ala Gln Asp  Ser Cys Leu Glu Ala  Arg Lys Ser 
    1145                 1150                 1155             


Gln Pro  Asp Glu Ser Cys Leu  Ser Ala Leu His Asn  Ser Ser Asp 
    1160                 1165                 1170             


Leu Glu  Leu Arg Ala Thr Pro  Glu Pro Ala Gln Thr  Gly Val Pro 
    1175                 1180                 1185             


Gln Gln  Val His Pro Thr Glu  Asp Glu Ala Ser Ser  Pro Trp Ser 
    1190                 1195                 1200             


Val Leu  Asn Ala Glu Leu Ser  Ser Gly Asp Asp Phe  Glu Thr Gln 
    1205                 1210                 1215             


Asp Asp  Arg Pro Cys Thr Leu  Ala Ser Thr Gly Thr  Asn Thr Asn 
    1220                 1225                 1230             


Glu Leu  Leu Ala Tyr Thr Asn  Ser Ala Leu Asp Lys  Ser Leu Ser 
    1235                 1240                 1245             


Ser His  Ser Glu Gly Pro Lys  Leu Lys Glu Pro Asp  Ile Glu Gly 
    1250                 1255                 1260             


Lys Tyr  Leu Gly Lys Leu Gly  Val Ser Gly Met Leu  Asp Leu Ser 
    1265                 1270                 1275             


Glu Asp  Gly Met Asp Ala Asp  Glu Glu Asp Glu Asn  Ser Asp Asp 
    1280                 1285                 1290             


Ser Asp  Glu Asp Leu Arg Ala  Phe Asn Leu His Ser  Leu Ser Ser 
    1295                 1300                 1305             


Glu Ser  Glu Asp Glu Thr Glu  His Pro Val Pro Ile  Ile Leu Ser 
    1310                 1315                 1320             


Asn Glu  Asp Gly Arg His Leu  Arg Ser Leu Leu Lys  Pro Thr Ala 
    1325                 1330                 1335             


Ala Asn  Ala Pro Asp Pro Leu  Pro Glu Asp Trp Lys  Lys Glu Lys 
    1340                 1345                 1350             


Lys Ala  Val Thr Phe Phe Asp  Asp Val Thr Val Tyr  Leu Phe Asp 
    1355                 1360                 1365             


Gln Glu  Thr Pro Thr Lys Glu  Leu Gly Pro Cys Gly  Gly Glu Ala 
    1370                 1375                 1380             


Cys Gly  Pro Asp Leu Ser Gly  Pro Ala Pro Ala Ser  Gly Ser Pro 
    1385                 1390                 1395             


Tyr Leu  Ser Arg Cys Ile Asn  Ser Glu Ser Ser Thr  Asp Glu Glu 
    1400                 1405                 1410             


Gly Gly  Gly Phe Glu Trp Asp  Asp Asp Phe Ser Pro  Asp Pro Phe 
    1415                 1420                 1425             


Met Ser  Lys Thr Thr Ser Asn  Leu Leu Ser Ser Lys  Pro Ser Leu 
    1430                 1435                 1440             


Gln Thr  Ser Lys Tyr Phe Ser  Pro Pro Pro Pro Ala  Arg Ser Thr 
    1445                 1450                 1455             


Glu Gln  Ser Trp Pro His Ser  Ala Pro Tyr Ser Arg  Phe Ser Ile 
    1460                 1465                 1470             


Ser Pro  Ala Asn Ile Ala Ser  Phe Ser Leu Thr His  Leu Thr Asp 
    1475                 1480                 1485             


Ser Asp  Ile Glu Gln Gly Gly  Ser Ser Glu Asp Gly  Glu Lys Asp 
    1490                 1495                 1500             


<210>  6268
<211>  1489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMTK3__Homo_sapiens__NP_001073903

<400>  6268

Met Arg Gln Val Leu Trp Leu Cys Asn Val Cys Val Thr Ala Arg Glu 
1               5                   10                  15      


Thr Arg His His Leu His Leu Pro Ala Ile Leu Asp Lys Met Pro Ala 
            20                  25                  30          


Pro Gly Ala Leu Ile Leu Leu Ala Ala Val Ser Ala Ser Gly Cys Leu 
        35                  40                  45              


Ala Ser Pro Ala His Pro Asp Gly Phe Ala Leu Gly Arg Ala Pro Leu 
    50                  55                  60                  


Ala Pro Pro Tyr Ala Val Val Leu Ile Ser Cys Ser Gly Leu Leu Ala 
65                  70                  75                  80  


Phe Ile Phe Leu Leu Leu Thr Cys Leu Cys Cys Lys Arg Gly Asp Val 
                85                  90                  95      


Gly Phe Lys Glu Phe Glu Asn Pro Glu Gly Glu Asp Cys Ser Gly Glu 
            100                 105                 110         


Tyr Thr Pro Pro Ala Glu Glu Thr Ser Ser Ser Gln Ser Leu Pro Asp 
        115                 120                 125             


Val Tyr Ile Leu Pro Leu Ala Glu Val Ser Leu Pro Met Pro Ala Pro 
    130                 135                 140                 


Gln Pro Ser His Ser Asp Met Thr Thr Pro Leu Gly Leu Ser Arg Gln 
145                 150                 155                 160 


His Leu Ser Tyr Leu Gln Glu Ile Gly Ser Gly Trp Phe Gly Lys Val 
                165                 170                 175     


Ile Leu Gly Glu Ile Phe Ser Asp Tyr Thr Pro Ala Gln Val Val Val 
            180                 185                 190         


Lys Glu Leu Arg Ala Ser Ala Gly Pro Leu Glu Gln Arg Lys Phe Ile 
        195                 200                 205             


Ser Glu Ala Gln Pro Tyr Arg Ser Leu Gln His Pro Asn Val Leu Gln 
    210                 215                 220                 


Cys Leu Gly Leu Cys Val Glu Thr Leu Pro Phe Leu Leu Ile Met Glu 
225                 230                 235                 240 


Phe Cys Gln Leu Gly Asp Leu Lys Arg Tyr Leu Arg Ala Gln Arg Pro 
                245                 250                 255     


Pro Glu Gly Leu Ser Pro Glu Leu Pro Pro Arg Asp Leu Arg Thr Leu 
            260                 265                 270         


Gln Arg Met Gly Leu Glu Ile Ala Arg Gly Leu Ala His Leu His Ser 
        275                 280                 285             


His Asn Tyr Val His Ser Asp Leu Ala Leu Arg Asn Cys Leu Leu Thr 
    290                 295                 300                 


Ser Asp Leu Thr Val Arg Ile Gly Asp Tyr Gly Leu Ala His Ser Asn 
305                 310                 315                 320 


Tyr Lys Glu Asp Tyr Tyr Leu Thr Pro Glu Arg Leu Trp Ile Pro Leu 
                325                 330                 335     


Arg Trp Ala Ala Pro Glu Leu Leu Gly Glu Leu His Gly Thr Phe Met 
            340                 345                 350         


Val Val Asp Gln Ser Arg Glu Ser Asn Ile Trp Ser Leu Gly Val Thr 
        355                 360                 365             


Leu Trp Glu Leu Phe Glu Phe Gly Ala Gln Pro Tyr Arg His Leu Ser 
    370                 375                 380                 


Asp Glu Glu Val Leu Ala Phe Val Val Arg Gln Gln His Val Lys Leu 
385                 390                 395                 400 


Ala Arg Pro Arg Leu Lys Leu Pro Tyr Ala Asp Tyr Trp Tyr Asp Ile 
                405                 410                 415     


Leu Gln Ser Cys Trp Arg Pro Pro Ala Gln Arg Pro Ser Ala Ser Asp 
            420                 425                 430         


Leu Gln Leu Gln Leu Thr Tyr Leu Leu Ser Glu Arg Pro Pro Arg Pro 
        435                 440                 445             


Pro Pro Pro Pro Pro Pro Pro Arg Asp Gly Pro Phe Pro Trp Pro Trp 
    450                 455                 460                 


Pro Pro Ala His Ser Ala Pro Arg Pro Gly Thr Leu Ser Ser Pro Phe 
465                 470                 475                 480 


Pro Leu Leu Asp Gly Phe Pro Gly Ala Asp Pro Asp Asp Val Leu Thr 
                485                 490                 495     


Val Thr Glu Ser Ser Arg Gly Leu Asn Leu Glu Cys Leu Trp Glu Lys 
            500                 505                 510         


Ala Arg Arg Gly Ala Gly Arg Gly Gly Gly Ala Pro Ala Trp Gln Pro 
        515                 520                 525             


Ala Ser Ala Pro Pro Ala Pro His Ala Asn Pro Ser Asn Pro Phe Tyr 
    530                 535                 540                 


Glu Ala Leu Ser Thr Pro Ser Val Leu Pro Val Ile Ser Ala Arg Ser 
545                 550                 555                 560 


Pro Ser Val Ser Ser Glu Tyr Tyr Ile Arg Leu Glu Glu His Gly Ser 
                565                 570                 575     


Pro Pro Glu Pro Leu Phe Pro Asn Asp Trp Asp Pro Leu Asp Pro Gly 
            580                 585                 590         


Val Pro Ala Pro Gln Ala Pro Gln Ala Pro Ser Glu Val Pro Gln Leu 
        595                 600                 605             


Val Ser Glu Thr Trp Ala Ser Pro Leu Phe Pro Ala Pro Arg Pro Phe 
    610                 615                 620                 


Pro Ala Gln Ser Ser Ala Ser Gly Ser Phe Leu Leu Ser Gly Trp Asp 
625                 630                 635                 640 


Pro Glu Gly Arg Gly Ala Gly Glu Thr Leu Ala Gly Asp Pro Ala Glu 
                645                 650                 655     


Val Leu Gly Glu Arg Gly Thr Ala Pro Trp Val Glu Glu Glu Glu Glu 
            660                 665                 670         


Glu Glu Glu Gly Ser Ser Pro Gly Glu Asp Ser Ser Ser Leu Gly Gly 
        675                 680                 685             


Gly Pro Ser Arg Arg Gly Pro Leu Pro Cys Pro Leu Cys Ser Arg Glu 
    690                 695                 700                 


Gly Ala Cys Ser Cys Leu Pro Leu Glu Arg Gly Asp Ala Val Ala Gly 
705                 710                 715                 720 


Trp Gly Gly His Pro Ala Leu Gly Cys Pro His Pro Pro Glu Asp Asp 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Arg Gly Ser Leu Ala Asp Leu Pro Met Ala 
            740                 745                 750         


Pro Pro Ala Ser Ala Pro Pro Glu Phe Leu Asp Pro Leu Met Gly Ala 
        755                 760                 765             


Ala Ala Pro Gln Tyr Pro Gly Arg Gly Pro Pro Pro Ala Pro Pro Pro 
    770                 775                 780                 


Pro Pro Pro Pro Pro Arg Ala Pro Ala Asp Pro Ala Ala Ser Pro Asp 
785                 790                 795                 800 


Pro Pro Ser Ala Val Ala Ser Pro Gly Ser Gly Leu Ser Ser Pro Gly 
                805                 810                 815     


Pro Lys Pro Gly Asp Ser Gly Tyr Glu Thr Glu Thr Pro Phe Ser Pro 
            820                 825                 830         


Glu Gly Ala Phe Pro Gly Gly Gly Ala Ala Glu Glu Glu Gly Val Pro 
        835                 840                 845             


Arg Pro Arg Ala Pro Pro Glu Pro Pro Asp Pro Gly Ala Pro Arg Pro 
    850                 855                 860                 


Pro Pro Asp Pro Gly Pro Leu Pro Leu Pro Gly Pro Arg Glu Lys Pro 
865                 870                 875                 880 


Thr Phe Val Val Gln Val Ser Thr Glu Gln Leu Leu Met Ser Leu Arg 
                885                 890                 895     


Glu Asp Val Thr Arg Asn Leu Leu Gly Glu Lys Gly Ala Thr Ala Arg 
            900                 905                 910         


Glu Thr Gly Pro Arg Lys Ala Gly Arg Gly Pro Gly Asn Arg Glu Lys 
        915                 920                 925             


Val Pro Gly Leu Asn Arg Asp Pro Thr Val Leu Gly Asn Gly Lys Gln 
    930                 935                 940                 


Ala Pro Ser Leu Ser Leu Pro Val Asn Gly Val Thr Val Leu Glu Asn 
945                 950                 955                 960 


Gly Asp Gln Arg Ala Pro Gly Ile Glu Glu Lys Ala Ala Glu Asn Gly 
                965                 970                 975     


Ala Leu Gly Ser Pro Glu Arg Glu Glu Lys Val Leu Glu Asn Gly Glu 
            980                 985                 990         


Leu Thr Pro Pro Arg Arg Glu Glu  Lys Ala Leu Glu Asn  Gly Glu Leu 
        995                 1000                 1005             


Arg Ser  Pro Glu Ala Gly Glu  Lys Val Leu Val Asn  Gly Gly Leu 
    1010                 1015                 1020             


Thr Pro  Pro Lys Ser Glu Asp  Lys Val Ser Glu Asn  Gly Gly Leu 
    1025                 1030                 1035             


Arg Phe  Pro Arg Asn Thr Glu  Arg Pro Pro Glu Thr  Gly Pro Trp 
    1040                 1045                 1050             


Arg Ala  Pro Gly Pro Trp Glu  Lys Thr Pro Glu Ser  Trp Gly Pro 
    1055                 1060                 1065             


Ala Pro  Thr Ile Gly Glu Pro  Ala Pro Glu Thr Ser  Leu Glu Arg 
    1070                 1075                 1080             


Ala Pro  Ala Pro Ser Ala Val  Val Ser Ser Arg Asn  Gly Gly Glu 
    1085                 1090                 1095             


Thr Ala  Pro Gly Pro Leu Gly  Pro Ala Pro Lys Asn  Gly Thr Leu 
    1100                 1105                 1110             


Glu Pro  Gly Thr Glu Arg Arg  Ala Pro Glu Thr Gly  Gly Ala Pro 
    1115                 1120                 1125             


Arg Ala  Pro Gly Ala Gly Arg  Leu Asp Leu Gly Ser  Gly Gly Arg 
    1130                 1135                 1140             


Ala Pro  Val Gly Thr Gly Thr  Ala Pro Gly Gly Gly  Pro Gly Ser 
    1145                 1150                 1155             


Gly Val  Asp Ala Lys Ala Gly  Trp Val Asp Asn Thr  Arg Pro Gln 
    1160                 1165                 1170             


Pro Pro  Pro Pro Pro Leu Pro  Pro Pro Pro Glu Ala  Gln Pro Arg 
    1175                 1180                 1185             


Arg Leu  Glu Pro Ala Pro Pro  Arg Ala Arg Pro Glu  Val Ala Pro 
    1190                 1195                 1200             


Glu Gly  Glu Pro Gly Ala Pro  Asp Ser Arg Ala Gly  Gly Asp Thr 
    1205                 1210                 1215             


Ala Leu  Ser Gly Asp Gly Asp  Pro Pro Lys Pro Glu  Arg Lys Gly 
    1220                 1225                 1230             


Pro Glu  Met Pro Arg Leu Phe  Leu Asp Leu Gly Pro  Pro Gln Gly 
    1235                 1240                 1245             


Asn Ser  Glu Gln Ile Lys Ala  Arg Leu Ser Arg Leu  Ser Leu Ala 
    1250                 1255                 1260             


Leu Pro  Pro Leu Thr Leu Thr  Pro Phe Pro Gly Pro  Gly Pro Arg 
    1265                 1270                 1275             


Arg Pro  Pro Trp Glu Gly Ala  Asp Ala Gly Ala Ala  Gly Gly Glu 
    1280                 1285                 1290             


Ala Gly  Gly Ala Gly Ala Pro  Gly Pro Ala Glu Glu  Asp Gly Glu 
    1295                 1300                 1305             


Asp Glu  Asp Glu Asp Glu Glu  Glu Asp Glu Glu Ala  Ala Ala Pro 
    1310                 1315                 1320             


Gly Ala  Ala Ala Gly Pro Arg  Gly Pro Gly Arg Ala  Arg Ala Ala 
    1325                 1330                 1335             


Pro Val  Pro Val Val Val Ser  Ser Ala Asp Ala Asp  Ala Ala Arg 
    1340                 1345                 1350             


Pro Leu  Arg Gly Leu Leu Lys  Ser Pro Arg Gly Ala  Asp Glu Pro 
    1355                 1360                 1365             


Glu Asp  Ser Glu Leu Glu Arg  Lys Arg Lys Met Val  Ser Phe His 
    1370                 1375                 1380             


Gly Asp  Val Thr Val Tyr Leu  Phe Asp Gln Glu Thr  Pro Thr Asn 
    1385                 1390                 1395             


Glu Leu  Ser Val Gln Ala Pro  Pro Glu Gly Asp Thr  Asp Pro Ser 
    1400                 1405                 1410             


Thr Pro  Pro Ala Pro Pro Thr  Pro Pro His Pro Ala  Thr Pro Gly 
    1415                 1420                 1425             


Asp Gly  Phe Pro Ser Asn Asp  Ser Gly Phe Gly Gly  Ser Phe Glu 
    1430                 1435                 1440             


Trp Ala  Glu Asp Phe Pro Leu  Leu Pro Pro Pro Gly  Pro Pro Leu 
    1445                 1450                 1455             


Cys Phe  Ser Arg Phe Ser Val  Ser Pro Ala Leu Glu  Thr Pro Gly 
    1460                 1465                 1470             


Pro Pro  Ala Arg Ala Pro Asp  Ala Arg Pro Ala Gly  Pro Val Glu 
    1475                 1480                 1485             


Asn 
    


<210>  6269
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMX1A__Homo_sapiens__NP_001167540

<400>  6269

Met Leu Asp Gly Leu Lys Met Glu Glu Asn Phe Gln Ser Ala Ile Asp 
1               5                   10                  15      


Thr Ser Ala Ser Phe Ser Ser Leu Leu Gly Arg Ala Val Ser Pro Lys 
            20                  25                  30          


Ser Val Cys Glu Gly Cys Gln Arg Val Ile Leu Asp Arg Phe Leu Leu 
        35                  40                  45              


Arg Leu Asn Asp Ser Phe Trp His Glu Gln Cys Val Gln Cys Ala Ser 
    50                  55                  60                  


Cys Lys Glu Pro Leu Glu Thr Thr Cys Phe Tyr Arg Asp Lys Lys Leu 
65                  70                  75                  80  


Tyr Cys Lys Tyr Asp Tyr Glu Lys Leu Phe Ala Val Lys Cys Gly Gly 
                85                  90                  95      


Cys Phe Glu Ala Ile Ala Pro Asn Glu Phe Val Met Arg Ala Gln Lys 
            100                 105                 110         


Ser Val Tyr His Leu Ser Cys Phe Cys Cys Cys Val Cys Glu Arg Gln 
        115                 120                 125             


Leu Gln Lys Gly Asp Glu Phe Val Leu Lys Glu Gly Gln Leu Leu Cys 
    130                 135                 140                 


Lys Gly Asp Tyr Glu Lys Glu Arg Glu Leu Leu Ser Leu Val Ser Pro 
145                 150                 155                 160 


Ala Ala Ser Asp Ser Gly Lys Ser Asp Asp Glu Glu Ser Leu Cys Lys 
                165                 170                 175     


Ser Ala His Gly Ala Gly Lys Gly Thr Ala Glu Glu Gly Lys Asp His 
            180                 185                 190         


Lys Arg Pro Lys Arg Pro Arg Thr Ile Leu Thr Thr Gln Gln Arg Arg 
        195                 200                 205             


Ala Phe Lys Ala Ser Phe Glu Val Ser Ser Lys Pro Cys Arg Lys Val 
    210                 215                 220                 


Arg Glu Thr Leu Ala Ala Glu Thr Gly Leu Ser Val Arg Val Val Gln 
225                 230                 235                 240 


Val Trp Phe Gln Asn Gln Arg Ala Lys Met Lys Lys Leu Ala Arg Arg 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Asp Gln Gln Asn Thr Gln Arg Leu Ser Ser 
            260                 265                 270         


Ala Gln Thr Asn Gly Gly Gly Ser Ala Gly Met Glu Gly Ile Met Asn 
        275                 280                 285             


Pro Tyr Thr Ala Leu Pro Thr Pro Gln Gln Leu Leu Ala Ile Glu Gln 
    290                 295                 300                 


Ser Val Tyr Ser Ser Asp Pro Phe Arg Gln Gly Leu Thr Pro Pro Gln 
305                 310                 315                 320 


Met Pro Gly Asp His Met His Pro Tyr Gly Ala Glu Pro Leu Phe His 
                325                 330                 335     


Asp Leu Asp Ser Asp Asp Thr Ser Leu Ser Asn Leu Gly Asp Cys Phe 
            340                 345                 350         


Leu Ala Thr Ser Glu Ala Gly Pro Leu Gln Ser Arg Val Gly Asn Pro 
        355                 360                 365             


Ile Asp His Leu Tyr Ser Met Gln Asn Ser Tyr Phe Thr Ser 
    370                 375                 380         


<210>  6270
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LMX1B__Homo_sapiens__NP_001167617

<400>  6270

Met Asp Ile Ala Thr Gly Pro Glu Ser Leu Glu Arg Cys Phe Pro Arg 
1               5                   10                  15      


Gly Gln Thr Asp Cys Ala Lys Met Leu Asp Gly Ile Lys Met Glu Glu 
            20                  25                  30          


His Ala Leu Arg Pro Gly Pro Ala Thr Leu Gly Val Leu Leu Gly Ser 
        35                  40                  45              


Asp Cys Pro His Pro Ala Val Cys Glu Gly Cys Gln Arg Pro Ile Ser 
    50                  55                  60                  


Asp Arg Phe Leu Met Arg Val Asn Glu Ser Ser Trp His Glu Glu Cys 
65                  70                  75                  80  


Leu Gln Cys Ala Ala Cys Gln Gln Ala Leu Thr Thr Ser Cys Tyr Phe 
                85                  90                  95      


Arg Asp Arg Lys Leu Tyr Cys Lys Gln Asp Tyr Gln Gln Leu Phe Ala 
            100                 105                 110         


Ala Lys Cys Ser Gly Cys Met Glu Lys Ile Ala Pro Thr Glu Phe Val 
        115                 120                 125             


Met Arg Ala Leu Glu Cys Val Tyr His Leu Gly Cys Phe Cys Cys Cys 
    130                 135                 140                 


Val Cys Glu Arg Gln Leu Arg Lys Gly Asp Glu Phe Val Leu Lys Glu 
145                 150                 155                 160 


Gly Gln Leu Leu Cys Lys Gly Asp Tyr Glu Lys Glu Lys Asp Leu Leu 
                165                 170                 175     


Ser Ser Val Ser Pro Asp Glu Ser Asp Ser Val Lys Ser Glu Asp Glu 
            180                 185                 190         


Asp Gly Asp Met Lys Pro Ala Lys Gly Gln Gly Ser Gln Ser Lys Gly 
        195                 200                 205             


Ser Gly Asp Asp Gly Lys Asp Pro Arg Arg Pro Lys Arg Pro Arg Thr 
    210                 215                 220                 


Ile Leu Thr Thr Gln Gln Arg Arg Ala Phe Lys Ala Ser Phe Glu Val 
225                 230                 235                 240 


Ser Ser Lys Pro Cys Arg Lys Val Arg Glu Thr Leu Ala Ala Glu Thr 
                245                 250                 255     


Gly Leu Ser Val Arg Val Val Gln Val Trp Phe Gln Asn Gln Arg Ala 
            260                 265                 270         


Lys Met Lys Lys Leu Ala Arg Arg His Gln Gln Gln Gln Glu Gln Gln 
        275                 280                 285             


Asn Ser Gln Arg Leu Gly Gln Gly Glu Pro Gly Pro Gly Gln Gly Leu 
    290                 295                 300                 


Gly Gln Glu Val Leu Ser Ser Arg Met Glu Gly Met Met Ala Ser Tyr 
305                 310                 315                 320 


Thr Pro Leu Ala Pro Pro Gln Gln Gln Ile Val Ala Met Glu Gln Ser 
                325                 330                 335     


Pro Tyr Gly Ser Ser Asp Pro Phe Gln Gln Gly Leu Thr Pro Pro Gln 
            340                 345                 350         


Met Pro Gly Asn Asp Ser Ile Phe His Asp Ile Asp Ser Asp Thr Ser 
        355                 360                 365             


Leu Thr Ser Leu Ser Asp Cys Phe Leu Gly Ser Ser Asp Val Gly Ser 
    370                 375                 380                 


Leu Gln Ala Arg Val Gly Asn Pro Ile Asp Arg Leu Tyr Ser Met Gln 
385                 390                 395                 400 


Ser Ser Tyr Phe Ala Ser 
                405     


<210>  6271
<211>  1025
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LNPEP__Homo_sapiens__NP_005566

<400>  6271

Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile 
1               5                   10                  15      


Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys 
            20                  25                  30          


Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro 
        35                  40                  45              


Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu 
    50                  55                  60                  


Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser 
65                  70                  75                  80  


Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg 
                85                  90                  95      


Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val 
            100                 105                 110         


Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile 
        115                 120                 125             


Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys 
    130                 135                 140                 


Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu 
145                 150                 155                 160 


Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg 
                165                 170                 175     


Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly 
            180                 185                 190         


Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile 
        195                 200                 205             


Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala 
    210                 215                 220                 


Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His 
225                 230                 235                 240 


Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn 
                245                 250                 255     


Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr 
            260                 265                 270         


Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr 
        275                 280                 285             


Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro 
    290                 295                 300                 


Cys Phe Asp Glu Pro Ala 